From 0b32a3611f6c414b00d58cca4bdd0f09fa5919f3 Mon Sep 17 00:00:00 2001
From: LianeHughes <68756672+LianeHughes@users.noreply.github.com>
Date: Fri, 8 Dec 2023 12:48:58 +0100
Subject: [PATCH] minor updates

---
 .../resources-subprojects/taxprofiler.md      | 24 +++++++++----------
 data/publications.json                        |  2 +-
 data/publications_old.json                    |  1 +
 3 files changed, 14 insertions(+), 13 deletions(-)
 create mode 100644 data/publications_old.json

diff --git a/content/english/resources-subprojects/taxprofiler.md b/content/english/resources-subprojects/taxprofiler.md
index f81a6ce04..e039f1b43 100644
--- a/content/english/resources-subprojects/taxprofiler.md
+++ b/content/english/resources-subprojects/taxprofiler.md
@@ -1,20 +1,20 @@
 ---
-title: "Highly parallelised multi-taxonomic profiling of shotgun metagenomic data (taxprofiler)"
+title: "Highly parallelised multi-taxonomic profiling of shotgun metagenomic data (nf-core/taxprofiler)"
 category: "plp1"
 resource_info:
-    name: "Highly parallelised multi-taxonomic profiling of shotgun metagenomic data (taxprofiler)"
-    funded_project_title: "Joint contributions from 3 PLP projects: Rapid establishment of comprehensive laboratory pandemic preparedness – RAPID-SEQ (PLP1 capability), Genomic Pandemic Preparedness Portfolio (G3P) (PLP1 capability), and Next generation clinical virology (PLP TDP project)."
-    pi: Jan Albert (RAPID-SEQ), Valtteri Wirta (G3P), Tobias Allander (Next generation clinical virology)
-    host_organisation: Taxprofiler is an international initiative with Swedish contributions from Karolinska Institutet, Karolinska University Hospital, SciLifeLab, Region Östergötland and Genomic Medicine Sweden
-    use: "The development version of the pipeline is already publicly available for taxonomic classification of metagenomic data and it can be used for Pandemic Preparedness research as soon as the first stable release is available."
-    access: "The nf-core/taxprofiler is open-source pipeline."
-    data_etc: "All code related to the pipeline for taxprofiler is available on [GitHub](https://github.com/nf-core/taxprofiler)."
-    publications_etc: "Instructions about how to use the pipeline are available on [nf-core](https://nf-co.re/taxprofiler/dev/usage)."
-    webpage: "[https://nf-co.re/taxprofiler/dev](https://nf-co.re/taxprofiler/dev)"
-    contact: "Sofia Stamouli<br>Bioinformatician<br>Email: [sofia.stamouli@scilifelab.se](mailto:sofia.stamouli@scilifelab.se)"
+  name: "Highly parallelised multi-taxonomic profiling of shotgun metagenomic data (nf-core/taxprofiler)"
+  funded_project_title: "Joint contributions from 3 PLP projects: Rapid establishment of comprehensive laboratory pandemic preparedness – RAPID-SEQ (PLP1 capability), Genomic Pandemic Preparedness Portfolio (G3P) (PLP1 capability), and Next generation clinical virology (PLP TDP project)."
+  pi: Jan Albert (RAPID-SEQ), Valtteri Wirta (G3P), Tobias Allander (Next generation clinical virology)
+  host_organisation: nf-core/taxprofiler is an international initiative within nf-core community and Swedish contributions from Karolinska Institutet, Karolinska University Hospital, SciLifeLab, Region Östergötland and Genomic Medicine Sweden.
+  use: "The development version of the pipeline is already publicly available for taxonomic classification of metagenomic data and it can be used for Pandemic Preparedness research as soon as the first stable release is available."
+  access: "The nf-core/taxprofiler is open-source pipeline."
+  data_etc: "All code related to the pipeline for taxprofiler is available on [GitHub](https://github.com/nf-core/taxprofiler)."
+  publications_etc: "Instructions about how to use the pipeline are available on [nf-core](https://nf-co.re/taxprofiler/dev/usage)."
+  webpage: "[https://nf-co.re/taxprofiler/1.1.2](https://nf-co.re/taxprofiler/1.1.2)"
+  contact: "Sofia Stamouli<br>Bioinformatician<br>Email: [sofia.stamouli@scilifelab.se](mailto:sofia.stamouli@scilifelab.se)"
 ---
 
-A pipeline for taxonomic profiling of shotgun metagenomic data. It is currently in development and does not yet have any stable releases.
+A pipeline for taxonomic profiling of shotgun metagenomic data. The [first stable release](https://nf-co.re/taxprofiler/1.1.2) is publicly available.
 
 The pipeline supports metagenomic data generated both from Illumina and Nanopore sequencing technology. It performs in-parallel taxonomic profiling with multiple taxonomic classifiers against multiple databases and produces standardised output tables. In addition, it performs quality control and optional read pre-processing (adapter trimming, low-complexity filtering and host read removal).
 
diff --git a/data/publications.json b/data/publications.json
index 8ea921b2f..9f957177d 100644
--- a/data/publications.json
+++ b/data/publications.json
@@ -1 +1 @@
-{"entity": "publications", "timestamp": "2023-11-02T14:41:19.846Z", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publications.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publications"}}, "publications_count": 3405, "full": true, "publications": [{"entity": "publication", "iuid": "a5a5288d35b84c81a7211dc46aa3f8f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a5a5288d35b84c81a7211dc46aa3f8f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a5a5288d35b84c81a7211dc46aa3f8f9"}}, "title": "Confidence in COVID-19 vaccine effectiveness and safety and its effect on vaccine uptake in Tanzania: A community-based cross-sectional study.", "authors": [{"family": "Mtei", "given": "Monica", "initials": "M", "orcid": "0000-0002-0407-6593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0880cf78afbb447e9af763d5fcc063b6.json"}}, {"family": "Mboya", "given": "Innocent B", "initials": "IB"}, {"family": "Mgongo", "given": "Melina", "initials": "M"}, {"family": "Manongi", "given": "Rachel", "initials": "R"}, {"family": "Amour", "given": "Caroline", "initials": "C"}, {"family": "Bilakwate", "given": "Julieth S", "initials": "JS"}, {"family": "Nyaki", "given": "Ahmed Y", "initials": "AY"}, {"family": "Ngocho", "given": "James", "initials": "J"}, {"family": "Jonas", "given": "Norman", "initials": "N"}, {"family": "Farah", "given": "Amina", "initials": "A"}, {"family": "Amour", "given": "Maryam", "initials": "M"}, {"family": "Kalolo", "given": "Albino", "initials": "A"}, {"family": "Kengia", "given": "James T", "initials": "JT"}, {"family": "Tinuga", "given": "Florian", "initials": "F"}, {"family": "Ngalesoni", "given": "Frida", "initials": "F"}, {"family": "Bakari", "given": "Abdalla H", "initials": "AH"}, {"family": "Kirakoya", "given": "Fatimata B", "initials": "FB"}, {"family": "Araya", "given": "Awet", "initials": "A"}, {"family": "Kapologwe", "given": "Ntuli A", "initials": "NA"}, {"family": "Msuya", "given": "Sia E", "initials": "SE"}], "type": "journal article", "published": "2023-12-31", "journal": {"title": "Hum Vaccin Immunother", "issn": "2164-554X", "volume": "19", "issue": "1", "pages": "2191576", "issn-l": null}, "abstract": "COVID-19 is a major public health threat associated with increased disease burden, mortality, and economic loss to countries and communities. Safe and efficacious COVID-19 vaccines are key in halting and reversing the pandemic. Low confidence in vaccines has been one of the factors leading to hesitancy. We aimed to assess the COVID-19 vaccine confidence (safety and effectiveness), associated factors, and its effects on vaccine uptake among general community members in Tanzania. This was a community-based cross-sectional survey conducted from December 2021 to April 2022 in six regions of Tanzania mainland and two regions in Zanzibar. Participants were interviewed using an electronic questionnaire. Multiple logistic regression models estimated odds ratios (ORs) and 95% confidence interval (CI) for factors associated with vaccine confidence. All analyses were performed using SPSS version 25.0. The study enrolled 3470 general Tanzanian community members; their mean age was 40.3 (standard deviation \u00b114.9) years, and 34% were males. The proportion of COVID-19 vaccine confidence was 54.6%. Geographical region, residence area, COVID-19 disease risk perception, and good knowledge of COVID-19 vaccines were significantly associated with COVID-19 vaccine confidence. Confidence in COVID-19 vaccines was associated with over three times higher odds of vaccine uptake. Confidence in COVID-19 vaccines was low in Tanzania. Innovative community engagement strategies and region-specific interventions are needed to improve comprehensive knowledge and address community perceptions and attitudes toward COVID-19 vaccines.", "doi": "10.1080/21645515.2023.2191576", "pmid": "37017234", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10088920"}], "notes": [], "created": "2023-04-20T17:33:21.814Z", "modified": "2023-04-20T17:33:21.864Z"}, {"entity": "publication", "iuid": "e51c2b2f8cfd4821b00b9ade72030dce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e51c2b2f8cfd4821b00b9ade72030dce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e51c2b2f8cfd4821b00b9ade72030dce"}}, "title": "The influence of the Covid-19 pandemic on municipal meeting places arranging group exercise for older persons.", "authors": [{"family": "Dinse", "given": "Daniella", "initials": "D", "orcid": "0000-0002-4756-6728", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4aaa7aafbba646a39fabc6bb5c708549.json"}}, {"family": "Haak", "given": "Maria", "initials": "M", "orcid": "0000-0002-0054-2542", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b94642fc4c14e8991de97ae05cf49dc.json"}}, {"family": "Nilsson", "given": "Marie", "initials": "M", "orcid": "0000-0003-2762-7041", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6065be7342ee4a0786a7eb5ef9ed074c.json"}}, {"family": "Karlsson", "given": "Staffan", "initials": "S", "orcid": "0000-0002-6624-9963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e647df4e8b2455e939b74098c4a63c3.json"}}, {"family": "Olsson M\u00f6ller", "given": "Ulrika", "initials": "U", "orcid": "0000-0002-6879-9563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62ee4ccae36d4217a611c09fbfcea041.json"}}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Int J Qual Stud Health Well-being", "issn": "1748-2631", "issn-l": null, "volume": "18", "issue": "1", "pages": "2235130"}, "abstract": "Many municipalities today, together with other stakeholders, offer group exercises for the older population via municipal meeting places, focusing on promoting good health. During the Covid-19 pandemic, these group exercises either continued in a modified form or ceased. The aim of this study was to explore involved stakeholders' experiences of group exercises for older persons arranged via municipal meeting places during the Covid-19 pandemic.\r\n\r\nSix online focus group interviews were conducted with 25 stakeholders, such as decision-makers and representatives from the non-profit sector, from seven municipalities in Sweden. Data were analysed using thematic analysis.\r\n\r\nThe collaboration around the group exercises was challenged due to affected communication and decision-making. The stakeholders described the importance of adapting and finding new ways to offer group exercise. Furthermore, the re-arranging of group exercises created concerns about the well-being of the older persons but also happiness with the older persons ability to act for their own well-being during the pandemic.\r\n\r\nThis study highlights the importance of the municipalities exchanging experiences, making the older persons more involved in the decision-making process, enabling a person-centred encounter with the older persons when exercising in groups, and strengthening supportive environments by sharing the ownership of arranging the group exercises with the older persons.", "doi": "10.1080/17482631.2023.2235130", "pmid": "37499132", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10375932"}], "notes": [], "created": "2023-10-04T12:08:42.317Z", "modified": "2023-10-04T12:39:04.249Z"}, {"entity": "publication", "iuid": "2c7332149f534505b1cd8b604e924b12", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c7332149f534505b1cd8b604e924b12.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c7332149f534505b1cd8b604e924b12"}}, "title": "The experiences of patients ill with COVID-19-like symptoms and the role of testing for SARS-CoV-2 in supporting them: A qualitative study in eight European countries during the first wave of the pandemic.", "authors": [{"family": "Hoste", "given": "Melanie E", "initials": "ME", "orcid": "0000-0003-0831-3354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2e7d9961a0d486db33addd840a2f827.json"}}, {"family": "Wanat", "given": "Marta", "initials": "M"}, {"family": "Gobat", "given": "Nina", "initials": "N"}, {"family": "Anastasaki", "given": "Marilena", "initials": "M"}, {"family": "B\u00f6hmer", "given": "Femke", "initials": "F"}, {"family": "Chlabicz", "given": "S\u0142awomir", "initials": "S"}, {"family": "Colliers", "given": "Annelies", "initials": "A", "orcid": "0000-0003-4960-2355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/da75d309875249ab927e572db2b3ec91.json"}}, {"family": "Farrell", "given": "Karen", "initials": "K"}, {"family": "Karkana", "given": "Maria-Nefeli", "initials": "M"}, {"family": "Kinsman", "given": "John", "initials": "J"}, {"family": "Lionis", "given": "Christos", "initials": "C", "orcid": "0000-0002-9324-2839", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4f78c9751aa4b288a80e6dd903f3f56.json"}}, {"family": "Marcinowicz", "given": "Ludmila", "initials": "L"}, {"family": "Reinhardt", "given": "Katrin", "initials": "K"}, {"family": "Skoglund", "given": "Ingmarie", "initials": "I"}, {"family": "Sundvall", "given": "P\u00e4r-Daniel", "initials": "P"}, {"family": "Vellinga", "given": "Akke", "initials": "A", "orcid": "0000-0002-6583-4300", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84b752b8202048bca41ca262b5536985.json"}}, {"family": "Goossens", "given": "Herman", "initials": "H"}, {"family": "Butler", "given": "Christopher C", "initials": "CC"}, {"family": "van der Velden", "given": "Alike", "initials": "A"}, {"family": "Tonkin-Crine", "given": "Sarah", "initials": "S"}, {"family": "Anthierens", "given": "Sibyl", "initials": "S"}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Eur J Gen Pract", "issn": "1751-1402", "issn-l": null, "volume": "29", "issue": "2", "pages": "2212904"}, "abstract": "Access to testing during the first wave of the COVID-19 pandemic was limited, impacting patients with COVID-19-like symptoms. Current qualitative studies have been limited to one country or were conducted outside Europe.\r\n\r\nTo explore - in eight European countries - the experiences of patients consulting in primary care with COVID-19-like symptoms during the first wave of the pandemic.\r\n\r\nSixty-six semi-structured interviews, informed by a topic guide, were conducted by telephone or in person between April and July 2020. Patients with COVID-19-like symptoms were purposively recruited in primary care sites in eight countries and sampled based on age, gender, and symptom presentation. Deductive and inductive thematic analysis techniques were used to develop a framework representing data across settings. Data adequacy was attained by collecting rich data.\r\n\r\nSeven themes were identified, which described the experiences of patients consulting. Two themes are reported in this manuscript describing the role of COVID-19 testing in this experience. Patients described significant distress due to their symptoms, especially those at higher risk of complications from COVID-19, and those with severe symptoms. Patients wanted access to testing to identify the cause of their illness and minimise the burden of managing uncertainty. Some patients testing positive for COVID-19 assumed they would be immune from future infection.\r\n\r\nPatients experiencing novel and severe symptoms, particularly those with comorbidities, experienced a significant emotional and psychological burden due to concerns about COVID-19. Testing provided reassurance over health status and helped patients identify which guidance to follow. Testing positive for SARS-CoV-2 led to some patients thinking they were immune from future infection, thus influencing subsequent behaviour.", "doi": "10.1080/13814788.2023.2212904", "pmid": "37248990", "labels": {"Category: Social Science & Humanities": null, "Funder: H2020": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10249444"}], "notes": [], "created": "2023-10-04T05:08:51.674Z", "modified": "2023-10-04T05:30:49.922Z"}, {"entity": "publication", "iuid": "5479327ce61d4dd39f99c46c502b7f4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5479327ce61d4dd39f99c46c502b7f4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5479327ce61d4dd39f99c46c502b7f4c"}}, "title": "The distorted memories of patients treated in the intensive care unit during the COVID-19 pandemic: A qualitative study.", "authors": [{"family": "Vogel", "given": "Gisela", "initials": "G"}, {"family": "Forinder", "given": "Ulla", "initials": "U"}, {"family": "Sandgren", "given": "Anna", "initials": "A"}, {"family": "Svensen", "given": "Christer", "initials": "C"}, {"family": "Joelsson-Alm", "given": "Eva", "initials": "E"}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "issn-l": null, "volume": "79", "issue": null, "pages": "103522"}, "abstract": "During the COVID-19 pandemic, patients cared for in the intensive care unit were exposed to many risk factors for developing delirium and subsequent distorted memories. Further, seeing healthcare professionals who have been dressed in personal protective equipment and face masks could have affected the patients' memories. Therefore, the aim of this study was to explore memories and how they are experienced and managed by former patients who have been treated for COVID-19 in an intensive care unit.\r\n\r\nSixteen former patients treated for COVID-19 at a large emergency hospital in Sweden were interviewed 3-8 months after discharge from the intensive care unit. The data were interpreted using thematic analysis. The Consolidated Criteria for Reporting Qualitative Research checklist was followed in the reporting of the study.\r\n\r\nParticipants' descriptions of their memories of treatment in the intensive care unit for COVID-19 generated three themes: 'Distorted truth' the content in the memories which implied facing death in an unreal distorted environment. 'Captive,' was the experience and feelings linked to memories with a feeling of being exposed and alone, and 'Coping with memories' explained how participants managed the implications of the memories using a mixture of strategies.\r\n\r\nFor former patients who were admitted to an intensive care unit after a diagnosis of COVID-19, memories caused considerable distress, which were similar to other intensive care patient\u015b experiences, before the pandemic. Emotion-focused and problem-focused strategies could be used to cope with these memories. Healthcare professionals wearing protective equipment gave the patient a distant feeling, but more important was to be treated with attention/care and respect.\r\n\r\nAwareness of the impact of distorted memories on patients who are severely ill and their needs and strategies to cope with these memories can form the basis for early interventions that promotes well-being during care and recovery. Healthcare professionals have an important task to inform patients and their family members about the existence of distorted memories, and talk about the patients' experience of them, to facilitate their recovery.", "doi": "10.1016/j.iccn.2023.103522", "pmid": "37598502", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(23)00139-8"}], "notes": [], "created": "2023-10-05T08:08:44.568Z", "modified": "2023-10-06T04:33:26.762Z"}, {"entity": "publication", "iuid": "df1add79ba144dcc955eab39d23f0571", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/df1add79ba144dcc955eab39d23f0571.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/df1add79ba144dcc955eab39d23f0571"}}, "title": "Tailored internet-based psychological treatment for psychological problems during the COVID-19 pandemic: A randomized controlled trial.", "authors": [{"family": "Aminoff", "given": "Victoria", "initials": "V"}, {"family": "Bobeck", "given": "Johanna", "initials": "J"}, {"family": "Hjort", "given": "Sofia", "initials": "S"}, {"family": "S\u00f6rliden", "given": "Elise", "initials": "E"}, {"family": "Ludvigsson", "given": "Mikael", "initials": "M"}, {"family": "Berg", "given": "Matilda", "initials": "M"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Internet Interv", "issn": "2214-7829", "issn-l": "2214-7829", "volume": "34", "issue": null, "pages": "100662"}, "abstract": "The COVID-19 pandemic influence mental health in both infected and non-infected populations. In this study we examined if individually tailored internet-based cognitive behavioral therapy (ICBT) could be an effective treatment for psychological symptoms related to the pandemic. Following recruitment we included 76 participants who were randomized to either a treatment group (n = 37) or a waitlist control group (n = 39). The treatment group received 8 modules (out of 16 possible) during 8 weeks with weekly therapist support. We collected data on symptoms of depression, experienced quality of life, anxiety, stress, anger, insomnia, PTSD, and alcohol use before, after the treatment and at one year follow-up. Using multiple regression analysis, group condition was found to be a statistically significant predictor for a decrease, favoring the treatment group, in symptoms of depression, insomnia, and anger with small to moderate effect sizes. The improvements remained at one year follow-up. Group condition did not significantly predict changing symptoms regarding experienced quality of life, anxiety, stress, PTSD and alcohol use. Findings indicate that ICBT is an effective intervention for some psychological symptoms associated with the COVID-19 pandemic. There is a need for further studies on mechanisms of change and on tailored ICBT for problems associated with crises like the pandemic.", "doi": "10.1016/j.invent.2023.100662", "pmid": "37671335", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10475474"}, {"db": "pii", "key": "S2214-7829(23)00062-3"}], "notes": [], "created": "2023-10-06T06:56:36.372Z", "modified": "2023-10-06T11:19:54.405Z"}, {"entity": "publication", "iuid": "d8627c522c93438bab63f8c22c362e8c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d8627c522c93438bab63f8c22c362e8c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d8627c522c93438bab63f8c22c362e8c"}}, "title": "Public health restrictions, directives, and measures in Arctic countries in the first year of the COVID-19 pandemic.", "authors": [{"family": "Peterson", "given": "Malory", "initials": "M", "orcid": "0000-0001-9730-899X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/535cfc55eb4245238a543ceae4955aa0.json"}}, {"family": "Akearok", "given": "Gwen Healey", "initials": "GH", "orcid": "0000-0001-9507-2610", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d74acdff0470400cb32d8790f4c44c6a.json"}}, {"family": "Cueva", "given": "Katie", "initials": "K", "orcid": "0000-0002-8013-9680", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d904d970c544a9fb4a51aa0b54a3d07.json"}}, {"family": "Lavoie", "given": "Jos\u00e9e G", "initials": "JG", "orcid": "0000-0003-2483-431X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/979bb18295514ce28f361f6479080b98.json"}}, {"family": "Larsen", "given": "Christina Vl", "initials": "CV", "orcid": "0000-0002-6245-4222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/122c1ea2512947258ee6e0b3c727651e.json"}}, {"family": "J\u00f3hannsd\u00f3ttir", "given": "L\u00e1ra", "initials": "L", "orcid": "0000-0001-5912-3337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6cd00a909ab4a7fae2beb9765eaa4b6.json"}}, {"family": "Cook", "given": "David", "initials": "D", "orcid": "0000-0001-9200-0515", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0e0ad34240445e78514fd55ce6e76fa.json"}}, {"family": "Nilsson", "given": "Lena Maria", "initials": "LM", "orcid": "0000-0002-2354-7258", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1dc6f1b33370474f9ad51f370d9cf3c3.json"}}, {"family": "Rautio", "given": "Arja", "initials": "A", "orcid": "0000-0002-5816-533X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07a185cd1ef3427b9f49847cbd268617.json"}}, {"family": "Timlin", "given": "Ulla", "initials": "U", "orcid": "0000-0002-7840-4430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a0fcd3b9cb94ca58b719ed94812c719.json"}}, {"family": "San Sebasti\u00e1n", "given": "Miguel", "initials": "M", "orcid": "0000-0001-7234-3510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e7ccb93844f4bd6aba400b70261d37b.json"}}, {"family": "Gladun", "given": "Elena", "initials": "E", "orcid": "0000-0003-2525-6638", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/180f54a51ddc4c3ca988012e0c98a604.json"}}, {"family": "Rink", "given": "Elizabeth", "initials": "E", "orcid": "0000-0002-5738-5496", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5578d7332c574ea4988f8d94a988138b.json"}}, {"family": "Broderstadt", "given": "Ann Ragnhild", "initials": "AR", "orcid": "0000-0003-3843-6953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4de647a328304fd0be8fd6f308758d48.json"}}, {"family": "Dagsvold", "given": "Inger", "initials": "I"}, {"family": "Siri", "given": "Susanna", "initials": "S", "orcid": "0000-0003-3231-8139", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fa098be57c24667a8e4ffa526d1f12f.json"}}, {"family": "Ottendahl", "given": "Charlotte Brandstrup", "initials": "CB", "orcid": "0000-0002-9285-3099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c6f92de274540a0b3ad587252e69425.json"}}, {"family": "Olesen", "given": "Ingelise", "initials": "I"}, {"family": "Zatseva", "given": "Larisa", "initials": "L"}, {"family": "Young", "given": "Rebecca Ipiaqruk", "initials": "RI", "orcid": "0009-0009-3502-1147", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db8a63fdb6f84bf6875a32f57a066840.json"}}, {"family": "Chaliak", "given": "Ay'aqulluk Jim", "initials": "AJ", "orcid": "0009-0003-0559-0871", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba18ca8951c14fbba3f58123107f15ba.json"}}, {"family": "Ophus", "given": "Emily", "initials": "E"}, {"family": "Stoor", "given": "Jon Petter A", "initials": "JPA", "orcid": "0000-0002-1580-8307", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61077580fa204d84ada7e7cdc395dadc.json"}}], "type": "review", "published": "2023-12-00", "journal": {"title": "Int J Circumpolar Health", "issn": "2242-3982", "issn-l": null, "volume": "82", "issue": "1", "pages": "2271211"}, "abstract": "Beginning January of 2020, COVID-19 cases detected in Arctic countries triggered government policy responses to stop transmission and limit caseloads beneath levels that would overwhelm existing healthcare systems. This review details the various restrictions, health mandates, and transmission mitigation strategies imposed by governments in eight Arctic countries (the United States, Canada, Greenland, Norway, Finland, Sweden, Iceland, and Russia) during the first year of the COVID-19 pandemic, through 31 January 2021s31 January 2021. We highlight formal protocols and informal initiatives adopted by local communities in each country, beyond what was mandated by regional or national governments. This review documents travel restrictions, communications, testing strategies, and use of health technology to track and monitor COVID-19 cases. We provide geographical and sociocultural background and draw on local media and communications to contextualise the impact of COVID-19 emergence and prevention measures in Indigenous communities in the Arctic. Countries saw varied case rates associated with local protocols, governance, and population. Still, almost all regions maintained low COVID-19 case rates until November of 2020. This review was produced as part of an international collaboration to identify community-driven, evidence-based promising practices and recommendations to inform pan-Arctic collaboration and decision making in public health during global emergencies.", "doi": "10.1080/22423982.2023.2271211", "pmid": "37898999", "labels": {"Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:32:19.806Z", "modified": "2023-11-02T07:01:24.967Z"}, {"entity": "publication", "iuid": "b884f27250514663a9b65039859959f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b884f27250514663a9b65039859959f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b884f27250514663a9b65039859959f7"}}, "title": "Prevalence and factors associated with healthcare avoidance during the COVID-19 pandemic among the S\u00e1mi in Sweden: the S\u00e1miHET study.", "authors": [{"family": "Dresse", "given": "Menayit Tamrat", "initials": "MT", "orcid": "0000-0003-4830-8242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/16cf2e49e4234a4294b5b9ab46f57487.json"}}, {"family": "Stoor", "given": "Jon Petter", "initials": "JP", "orcid": "0000-0002-1580-8307", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61077580fa204d84ada7e7cdc395dadc.json"}}, {"family": "San Sebastian", "given": "Miguel", "initials": "M", "orcid": "0000-0001-7234-3510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e7ccb93844f4bd6aba400b70261d37b.json"}}, {"family": "Nilsson", "given": "Lena Maria", "initials": "LM", "orcid": "0000-0002-2354-7258", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1dc6f1b33370474f9ad51f370d9cf3c3.json"}}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Int J Circumpolar Health", "issn": "2242-3982", "issn-l": null, "volume": "82", "issue": "1", "pages": "2213909"}, "abstract": "The aim of this population-based cross-sectional study was to assess the prevalence of healthcare avoidance during the COVID-19 pandemic and its associated factors among the S\u00e1mi population in Sweden. Data from the \"S\u00e1mi Health on Equal Terms\" (S\u00e1miHET) survey conducted in 2021 were used. Overall, 3,658 individuals constituted the analytical sample. Analysis was framed using the social determinants of health framework. The association between healthcare avoidance and several sociodemographic, material, and cultural factors was explored through log-binomial regression analyses. Sampling weights were applied in all analyses. Thirty percent of the S\u00e1mi in Sweden avoided healthcare during the COVID-19 pandemic. S\u00e1mi women (PR: 1.52, 95% CI: 1.36-1.70), young adults (PR: 1.22, 95% CI:1.05-1.47), S\u00e1mi living outside S\u00e1pmi (PR: 1.17, 95% CI: 1.03-1.34), and those having low income (PR: 1.42, 95% CI:1.19-1.68) and experiencing economic stress (PR: 1.48, 95% CI: 1.31-1.67) had a higher prevalence of healthcare avoidance. The pattern shown in this study can be useful for planning future pandemic responses, which should address healthcare avoidance, particularly among the identified vulnerable groups, including the active participation of the S\u00e1mi themselves.", "doi": "10.1080/22423982.2023.2213909", "pmid": "37216571", "labels": {"Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10208175"}], "notes": [], "created": "2023-10-04T05:09:51.425Z", "modified": "2023-10-04T06:18:54.180Z"}, {"entity": "publication", "iuid": "4b91c5e8663548b2a09a41385d1c5d92", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b91c5e8663548b2a09a41385d1c5d92.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b91c5e8663548b2a09a41385d1c5d92"}}, "title": "Low-intensity online mindfulness-based intervention for university students with anxiety during the COVID-19 pandemic-A randomized controlled trial with 3-month follow-up.", "authors": [{"family": "Young", "given": "Daniel Kim-Wan", "initials": "DK"}, {"family": "Carlbring", "given": "Per", "initials": "P"}, {"family": "Ng", "given": "Petrus Yat-Nam", "initials": "PY"}, {"family": "Cheng", "given": "Daphne Yi Ting", "initials": "DYT"}, {"family": "Chen", "given": "Joseph Qi-Rong", "initials": "JQ"}, {"family": "Ng", "given": "Siu-Man", "initials": "S"}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Internet Interv", "issn": "2214-7829", "issn-l": "2214-7829", "volume": "34", "issue": null, "pages": "100665"}, "abstract": "This study investigated the effectiveness of a low-intensity online mindfulness-based Intervention (iMBI) for alleviating anxiety in university students during the COVID-19 pandemic.\r\n\r\nIn a randomized controlled trial involving 134 participants from a local university in Hong Kong, subjects were randomly assigned to either the intervention group (n = 67) or the inactive control group (n = 67). The intervention group participated in a low-intensity iMBI comprising 16 online modules and two half-day online mindfulness workshops over an eight-week period. Outcomes were measured via an online platform using standardized assessment scales, including the Beck Anxiety Inventory and the Chinese Five Facets Mindfulness Questionnaire, at three different time points: pre-intervention, post-intervention and at a three-month follow-up.\r\n\r\nIntent-to-treat analysis using 2 (group) \u00d7 3 (time) repeated measures of covariance (ANCOVA) showed that the intervention group, compared to the control group, showed a significant reduction in anxiety symptoms with a medium effect size (Cohen's d = 0.5) and a significant improvement in mindfulness skills with a medium effect size (Cohen's d = 0.5) at post-intervention. The effects of the intervention in reducing anxiety and improving mindfulness persisted at the three-month follow-up.\r\n\r\nThe results of this study demonstrate the effectiveness of the low-intensity iMBI in alleviating anxiety among university students.", "doi": "10.1016/j.invent.2023.100665", "pmid": "37840645", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10569980"}, {"db": "pii", "key": "S2214-7829(23)00065-9"}], "notes": [], "created": "2023-11-01T13:34:14.816Z", "modified": "2023-11-02T07:44:47.549Z"}, {"entity": "publication", "iuid": "a7f18fab206d4d86aa561ea378cbcee3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7f18fab206d4d86aa561ea378cbcee3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7f18fab206d4d86aa561ea378cbcee3"}}, "title": "Effects of fine particulate matter (PM2.5) and meteorological factors on the daily confirmed cases of COVID-19 in Bangkok during 2020\u20132021, Thailand", "authors": [{"family": "Sangkham", "given": "Sarawut", "initials": "S", "orcid": "0000-0002-0507-0177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/156042be10a148acbf5fddef6e7b3b6f.json"}}, {"family": "Islam", "given": "Md Aminul", "initials": "MA"}, {"family": "Sarndhong", "given": "Kritsada", "initials": "K"}, {"family": "Vongruang", "given": "Patipat", "initials": "P"}, {"family": "Hasan", "given": "Mohammad Nayeem", "initials": "MN"}, {"family": "Tiwari", "given": "Ananda", "initials": "A"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}], "type": "journal-article", "published": "2023-12-00", "journal": {"title": "Case Studies in Chemical and Environmental Engineering", "issn": "2666-0164", "issn-l": null, "volume": "8", "issue": null, "pages": "100410"}, "abstract": null, "doi": "10.1016/j.cscee.2023.100410", "pmid": null, "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:33:28.320Z", "modified": "2023-10-04T09:41:09.413Z"}, {"entity": "publication", "iuid": "f95d3431743140bd81bff9689e633b9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f95d3431743140bd81bff9689e633b9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f95d3431743140bd81bff9689e633b9c"}}, "title": "Adolescents' and young people's experiences of social relationships and health concerns during COVID-19.", "authors": [{"family": "Sundler", "given": "Annelie J", "initials": "AJ", "orcid": "0000-0002-9194-3244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7308e89c2f4840268add7c61d26e3fbb.json"}}, {"family": "Bergnehr", "given": "Disa", "initials": "D", "orcid": "0000-0002-6357-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/524674f9584741db8884173f5a79cad3.json"}}, {"family": "Haffejee", "given": "Sadiyya", "initials": "S", "orcid": "0000-0002-9513-6861", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adb65c4ef1ee434caf5e5d7072480208.json"}}, {"family": "Iqbal", "given": "Humera", "initials": "H", "orcid": "0000-0002-3437-3759", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5185c706da4645b2b876109b656311f1.json"}}, {"family": "Orellana", "given": "Marjorie Faulstich", "initials": "MF", "orcid": "0000-0003-2921-5892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33c2dafbb15e4ba4857a757eda516d56.json"}}, {"family": "Vergara Del Solar", "given": "Ana", "initials": "A", "orcid": "0000-0001-7823-3769", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6af89e09de6e455885fffab8c124d47b.json"}}, {"family": "Angeles", "given": "Sophia L", "initials": "SL", "orcid": "0000-0003-1407-2753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc7a158043034ea48799125447ef5dfd.json"}}, {"family": "Faircloth", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-2919-2814", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ac7f62100114af098aee4e7e914c5ef.json"}}, {"family": "Liu", "given": "Lu", "initials": "L", "orcid": "0000-0003-2101-4586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88b3fd92889a4da58f1f77857c4db6ff.json"}}, {"family": "Mwanda", "given": "Anita", "initials": "A", "orcid": "0000-0001-8161-0000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f796590cf01b494f80336fd93d14b87a.json"}}, {"family": "Sep\u00falveda Galeas", "given": "Mauricio", "initials": "M", "orcid": "0000-0002-0736-6596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a5aa9dfad67421fae144dc866e9f1e2.json"}}, {"family": "Simelane", "given": "Thandi", "initials": "T", "orcid": "0000-0001-9906-1820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8443cdc6041c4a7ba103d8413c810b78.json"}}, {"family": "Twamley", "given": "Katherine", "initials": "K", "orcid": "0000-0001-8701-7427", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a090cb6978b14bebb226e224a6347c1b.json"}}, {"family": "Darcy", "given": "Laura", "initials": "L", "orcid": "0000-0002-9383-0227", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ed200c452dc423981354cc103223c0c.json"}}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Int J Qual Stud Health Well-being", "issn": "1748-2631", "issn-l": null, "volume": "18", "issue": "1", "pages": "2251236"}, "abstract": "To illuminate the meaning of social relationships and health concerns as experienced by adolescents and young people during the COVID-19 pandemic.\r\n\r\nA longitudinal qualitative study was conducted. Data reported from 172 adolescents and young people aged 12-24 years in five countries; Chile, South Africa, Sweden, the United Kingdom and the United States collected from May 2020 to June 2021 were analysed via thematic analysis.\r\n\r\nAdolescents and young peoples' experiences of social relationships and health concerns were described in seven themes: Family proximity, conflicts and frustration; difficulties and challenges related to limited living space; peer relations and maintaining friendship in times of social distancing; the importance of school as a place for interaction; vulnerability, emotional distress and uncertainty about the future; health concerns and sense of caring for others; and worries and concerns related to financial hardship. These reports show that the changes to everyday life that were introduced by public responses to the pandemic generated feelings of loneliness, vulnerability, and emotional distress, as well as increased sense of togetherness with family.\r\n\r\nThe everyday lives of adolescents and young people were restricted and affected more by the consequences of the pandemic than by the COVID-19 virus. These experiences had various impacts on well-being and mental health, where some individuals felt more exposed and vulnerable to emotional distress and loneliness than others. Family and peer relationships could be protective and support a sense of togetherness and belonging. Hence, social relationships are important to provide emotional support. Support for adolescents and young people should be tailored accordingly around social and emotional concerns, to encourage health and well-being.", "doi": "10.1080/17482631.2023.2251236", "pmid": "37639471", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10464546"}], "notes": [], "created": "2023-10-05T08:26:01.693Z", "modified": "2023-10-06T04:43:05.249Z"}, {"entity": "publication", "iuid": "b5b0aec2627946a0b9e29efb73968cd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5b0aec2627946a0b9e29efb73968cd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5b0aec2627946a0b9e29efb73968cd0"}}, "title": "A survey of pharmacists' perception of the work environment and patient safety in community pharmacies during the COVID-19 pandemic.", "authors": [{"family": "Ljungberg Persson", "given": "C", "initials": "C"}, {"family": "Nord\u00e9n H\u00e4gg", "given": "A", "initials": "A"}, {"family": "S\u00f6derg\u00e5rd", "given": "B", "initials": "B"}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Explor Res Clin Soc Pharm", "issn": "2667-2766", "issn-l": null, "volume": "12", "issue": null, "pages": "100327"}, "abstract": "Community pharmacies have changed during the COVID-19 pandemic, and new routines have been introduced to address the needs of customers and staff and to reduce the risk of spreading infection. Burnout has been described among staff possibly due to a changed working climate. However, little research has focused on the pandemic's effect on patient safety in community pharmacies.\r\n\r\nTo examine pharmacists' perceptions of the impact of the COVID-19 pandemic on workload, working environment, and patient safety in community pharmacies.\r\n\r\nA survey was distributed to all Swedish community pharmacists, constituting a census study. Questions regarding the pharmacists' perception of the impact of the pandemic on workload, working environment, and patient safety were included. Respondents were asked to provide comments on their working situation. Quantitative results were analysed using descriptive statistics, and comments were analysed using qualitative content analysis.\r\n\r\nThe response rate was 41% (2034 responses). Most pharmacists (62%) considered the workload to be increased during the pandemic while work environment deteriorated (physical work environment was considered worse by 47% of respondents while psychosocial work environment was considered worse by 59%). Despite this, many respondents (55%) believed that patient safety was not affected. Neither having had COVID-19 nor being afraid of contracting it, influenced these perceptions in any substantial way. Findings were consistent regardless of education, professional role, number of years in community pharmacies, or special assignments in the pharmacies. According to the respondents, the communication within pharmacy companies during the pandemic was inadequate.\r\n\r\nThe impact of the pandemic on working conditions is in line with previous findings but the effect on patient safety needs further studies. The respondents felt the management had a limited understanding of the conditions during the pandemic, which stresses the importance of good and clear communication during a crisis.", "doi": "10.1016/j.rcsop.2023.100327", "pmid": "37780549", "labels": {"Category: Social Science & Humanities": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10534261"}, {"db": "pii", "key": "S2667-2766(23)00108-7"}], "notes": [], "created": "2023-11-01T13:33:04.942Z", "modified": "2023-11-02T07:10:43.155Z"}, {"entity": "publication", "iuid": "0b40ee94b7b14b458eb231e8a2746373", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b40ee94b7b14b458eb231e8a2746373.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b40ee94b7b14b458eb231e8a2746373"}}, "title": "Safety, tolerability, and pharmacokinetics of half-life extended SARS-CoV-2-neutralizing monoclonal antibodies AZD7442 (tixagevimab/cilgavimab) in healthy Japanese adults.", "authors": [{"family": "Okada", "given": "Hiroshi", "initials": "H"}, {"family": "Ishikawa", "given": "Kensuke", "initials": "K"}, {"family": "Itoh", "given": "Yohji", "initials": "Y"}, {"family": "Noda", "given": "Yoshinori", "initials": "Y"}, {"family": "Eto", "given": "Takashi", "initials": "T"}, {"family": "Pilla Reddy", "given": "Venkatesh", "initials": "V"}, {"family": "Chen", "given": "Cecil Chi-Keung", "initials": "CC"}, {"family": "Gibbs", "given": "Michael", "initials": "M"}, {"family": "Johnsson", "given": "Eva", "initials": "E"}], "type": "randomized controlled trial", "published": "2023-11-00", "journal": {"title": "J Infect Chemother", "issn": "1437-7780", "issn-l": null, "volume": "29", "issue": "11", "pages": "1061-1067"}, "abstract": "The aim of this study was to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of AZD7442 (tixagevimab/cilgavimab) in healthy Japanese adults.\r\n\r\nIn this randomized, double-blind, placebo-controlled, phase 1 study, AZD7442 was administered intramuscularly (300 or 600 mg) or intravenously (300 or 1000 mg) to healthy Japanese adults. Primary endpoints were safety, tolerability, and pharmacokinetics. Anti-drug antibodies and neutralizing antibody activities were secondary endpoints.\r\n\r\nA total of 40 participants were randomized to receive AZD7442 (n = 30) or placebo (n = 10). Adverse events (AEs) occurred in 12 (40%) and 3 (30%) participants, respectively; there were no deaths, serious AEs, or AEs leading to study withdrawal. Tixagevimab and cilgavimab had mean half-lives of 82.1-95.9 and 77.9-92.0 days, respectively, which were generally similar regardless of administration route. SARS-CoV-2-neutralizing antibody titers were >4-fold higher than baseline levels from Day 8 to Day 211 in participants receiving AZD7442.\r\n\r\nAZD7442 was well tolerated in healthy Japanese adults, with predictable pharmacokinetics and an extended half-life, consistent with previous studies.\r\n\r\ngov, NCT04896541.", "doi": "10.1016/j.jiac.2023.07.014", "pmid": "37524201", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S1341-321X(23)00181-2"}, {"db": "ClinicalTrials.gov", "key": "NCT04896541"}], "notes": [], "created": "2023-10-05T08:27:04.847Z", "modified": "2023-10-06T05:19:49.899Z"}, {"entity": "publication", "iuid": "3b1550b3072e4388b2abda49ad05e774", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b1550b3072e4388b2abda49ad05e774.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b1550b3072e4388b2abda49ad05e774"}}, "title": "Monoclonal antibodies lock down SARS-CoV-2 spike.", "authors": [{"family": "Huang", "given": "Hsiang-Chi", "initials": "H"}, {"family": "Angeletti", "given": "Davide", "initials": "D"}], "type": "journal article", "published": "2023-11-00", "journal": {"title": "Trends Immunol", "issn": "1471-4981", "issn-l": null, "volume": "44", "issue": "11", "pages": "874-876"}, "abstract": "SARS-CoV-2 rapidly accumulated mutations in its immunodominant receptor-binding domain (RBD), rendering all clinically authorized monoclonal antibodies (mAbs) ineffective. Liu et al. unveil potent human mAbs that neutralize all tested SARS-CoV-2 variants by locking the Spike protein RBD in a downward conformation, thus inhibiting receptor engagement.", "doi": "10.1016/j.it.2023.09.006", "pmid": "37805348", "labels": {"Category: Vaccines": null, "Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1471-4906(23)00202-8"}], "notes": [], "created": "2023-11-01T13:33:13.225Z", "modified": "2023-11-02T07:15:29.144Z"}, {"entity": "publication", "iuid": "fff3a02de3024a11a9d52d9ce733906e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fff3a02de3024a11a9d52d9ce733906e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fff3a02de3024a11a9d52d9ce733906e"}}, "title": "Chronic Candida albicans meningitis following critical COVID-19 and serial measurements of (1,3)-\u03b2-D-glucan in cerebrospinal fluid.", "authors": [{"family": "Andreen", "given": "Niklas", "initials": "N"}, {"family": "Brink", "given": "Magnus", "initials": "M"}, {"family": "Hammarstr\u00f6m", "given": "Helena", "initials": "H"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}], "type": "journal article", "published": "2023-11-00", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": "55", "issue": "11", "pages": "794-797"}, "abstract": "Co-infections with invasive candidiasis have been reported to be overrepresented in severe COVID-19. This report presents an unusual case of chronic Candida meningitis following intensive care for COVID-19.", "doi": "10.1080/23744235.2023.2232448", "pmid": "37427429", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Serology": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:08:45.050Z", "modified": "2023-10-04T12:40:11.993Z"}, {"entity": "publication", "iuid": "11826c7f42bd491d80a67fe6d4f63446", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/11826c7f42bd491d80a67fe6d4f63446.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/11826c7f42bd491d80a67fe6d4f63446"}}, "title": "The sociodemographic patterning of sick leave and determinants of longer sick leave after mild and severe COVID-19: a nationwide register-based study in Sweden.", "authors": [{"family": "Spetz", "given": "Malin", "initials": "M"}, {"family": "Natt Och Dag", "given": "Yvonne", "initials": "Y"}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Nwaru", "given": "Chioma", "initials": "C"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Rosvall", "given": "Maria", "initials": "M", "orcid": "0000-0002-7122-9940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b220132e7064d50bb6649cd82a5bb42.json"}}], "type": "journal article", "published": "2023-10-27", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": null, "issue": null, "pages": null}, "abstract": "Studies on sociodemographic differences in sick leave after coronavirus disease 2019 (COVID-19) are limited and research on COVID-19 long-term health consequences has mainly addressed hospitalized individuals. The aim of this study was to investigate the social patterning of sick leave and determinants of longer sick leave after COVID-19 among mild and severe cases.\r\n\r\nThe study population, from the Swedish multi-register observational study SCIFI-PEARL, included individuals aged 18-64 years in the Swedish population, gainfully employed, with a first positive polymerase chain reaction (PCR) test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from 1 January 2020 until 31 August 2021 (n = 661 780). Using logistic regression models, analyses were adjusted for sociodemographic factors, vaccination, prior sick leave, comorbidities and stratified by hospitalization.\r\n\r\nIn total, 37 420 (5.7%) individuals were on sick leave due to COVID-19 in connection with their first positive COVID-19 test. Individuals on sick leave were more often women, older, had lower income and/or were born outside Sweden. These differences were similar across COVID-19 pandemic phases. The highest proportion of sick leave was seen in the oldest age group (10.3%) with an odds ratio of 4.32 (95% confidence interval 4.18-4.47) compared with the youngest individuals. Among individuals hospitalized due to COVID-19, the sociodemographic pattern was less pronounced, and in some models, even reversed. The intersectional analysis revealed considerable variability in sick leave between sociodemographic groups (range: 1.5-17.0%).\r\n\r\nIn the entire Swedish population of gainfully employed individuals, our findings demonstrated evident sociodemographic differences in sick leave due to COVID-19. In the hospitalized group, the social patterning was different and less pronounced.", "doi": "10.1093/eurpub/ckad191", "pmid": "37889580", "labels": {"Funder: VR": null, "Category: Social Science & Humanities": null, "Funder: KAW/SciLifeLab": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7331116"}], "notes": [], "created": "2023-11-01T13:31:38.666Z", "modified": "2023-11-01T13:43:47.208Z"}, {"entity": "publication", "iuid": "a3623fd6bde943a695f15b060417e12f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3623fd6bde943a695f15b060417e12f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3623fd6bde943a695f15b060417e12f"}}, "title": "How did providers of home care for older adults manage the early phase of the Covid-19 pandemic? A qualitative case study of managers' experiences in Region Stockholm.", "authors": [{"family": "Agerholm", "given": "Janne", "initials": "J"}, {"family": "Burstr\u00f6m", "given": "Bo", "initials": "B"}, {"family": "Sch\u00f6n", "given": "P\u00e4r", "initials": "P"}, {"family": "Liljas", "given": "Ann", "initials": "A"}], "type": "journal article", "published": "2023-10-27", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "issn-l": null, "volume": "23", "issue": "1", "pages": "1173"}, "abstract": "In the spring of 2020, the Covid-19 outbreak sent a shock wave through the Swedish society and placed an extraordinary pressure on the health and social care system for older people. In the initial phase there were few guidelines for care providers to follow and staff in home care organisations often had to tackle challenges posed by the pandemic as they appeared. The aim of this study was to understand how the spread of Covid-19 was managed in organisations providing home care to older adults in different municipalities in Region Stockholm, and what actions were taken to minimise the spread of the disease among clients and staff.\r\n\r\nA descriptive qualitative study was performed based on eight interviews with managers of home care providers for older adults in three different municipalities in Region Stockholm.Three of the eight providers operate within an integrated care system. Data were analysed using conventional content analysis.\r\n\r\nThree themes were identified covering actions taken to handle the spread of the virus, feelings of insecurity and anxiety, and internal and external factors influencing how the pandemic was tackled. There was no single strategy followed by all municipalities or organisations, however, there were similarities between the organisations. One such example was the introduction of cohort care and the experience of lacking personal protective equipment. Providers in the integrated care system emphasized some advantages with their system that was seen as facilitators for minimising the risk of spreading the virus, like the joint meetings with managers from both health and social care and the close contact with healthcare professionals in relation to dissemination of hygiene instructions.\r\n\r\nSocial care workers providing home care to older persons are an important group in preventing dissemination of infectious diseases like Covid-19. For better readiness and preparedness for future pandemics, municipal home care services would need larger stocks of personal protective equipment, clear guidelines and more training on how to reduce dissemination of disease. Ways to achieve closer communication between health and social care providers should also be investigated.", "doi": "10.1186/s12913-023-10173-8", "pmid": "37891523", "labels": {"Funder: VR": null, "Funder: Forte": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10612274"}, {"db": "pii", "key": "10.1186/s12913-023-10173-8"}], "notes": [], "created": "2023-11-01T13:32:23.591Z", "modified": "2023-11-02T07:03:41.915Z"}, {"entity": "publication", "iuid": "389a662518cd4a27a53b699cd6cea155", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/389a662518cd4a27a53b699cd6cea155.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/389a662518cd4a27a53b699cd6cea155"}}, "title": "Associations between psychosocial wellbeing and experience of gender-based violence at community, household, and intimate-partner levels among a cross-sectional cohort of young people living with and without HIV during COVID-19 in Cape Town, South Africa.", "authors": [{"family": "Hartmann", "given": "Miriam", "initials": "M"}, {"family": "Giovenco", "given": "Danielle", "initials": "D"}, {"family": "Zeebari", "given": "Zangin", "initials": "Z"}, {"family": "Itzikowitz", "given": "Gina", "initials": "G"}, {"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM"}, {"family": "Nielsen", "given": "Anna", "initials": "A"}, {"family": "Pettifor", "given": "Audrey", "initials": "A"}, {"family": "Bekker", "given": "Linda-Gail", "initials": "L"}, {"family": "K\u00e5gesten", "given": "Anna E", "initials": "AE"}], "type": "journal article", "published": "2023-10-27", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "23", "issue": "1", "pages": "2115"}, "abstract": "Growing evidence indicates that gender-based violence (GBV) increased during COVID-19. We investigated self-reported impact of the pandemic on GBV at community, household and intimate partner (IPV) levels among young people and its associations with psychosocial wellbeing, i.e., COVID-related stressors and mental health.\r\n\r\nCross-sectional data were drawn from a survey with young people ages 13-24 (N = 536) living with HIV (YPLWH) and without HIV (YPLWoH), in peri-urban Cape Town, South Africa. The survey, conducted February-October 2021, examined the impact of the initial lockdown on experience and perceived changes in GBV at each level, and pandemic-related psychosocial wellbeing. Descriptive statistics and binomial and multinomial regression analyses were conducted to illustrate exposure and perceived changes in GBV since lockdown, and their association with COVID-related stress factors (e.g., social isolation, anxiety about COVID), mental health (e.g., depression, anxiety), and other risk factors (e.g., age, gender, socioeconomic status) by HIV status.\r\n\r\nParticipants were 70% women with mean age 19 years; 40% were living with HIV. Since lockdown, YPLWoH were significantly more likely than YPLWH to perceive community violence as increasing (45% vs. 28%, p < 0.001), and to report household violence (37% vs. 23%, p = 0.006) and perceive it as increasing (56% vs. 27%, p = 0.002) (ref: decreasing violence). YPLWoH were also more likely to report IPV experience (19% vs. 15%, p = 0.41) and perception of IPV increasing (15% vs. 8%, p = 0.92). In adjusted models, COVID-related stressors and common mental health disorders were only associated with household violence. However, indicators of economic status such as living in informal housing (RRR = 2.07; 95% CI = 1.12-3.83) and food insecurity (Community violence: RRR = 1.79; 95% CI = 1.00-3.20; Household violence: RRR = 1.72; 95% CI = 1.15-2.60) emerged as significant risk factors for exposure to increased GBV particularly among YPLWoH.\r\n\r\nFindings suggest that for young people in this setting, GBV at community and household levels was more prevalent during COVID-19 compared to IPV, especially for YPLWoH. While we found limited associations between COVID-related stressors and GBV, the perceived increases in GBV since lockdown in a setting where GBV is endemic, and the association of household violence with mental health, is a concern for future pandemic responses and should be longitudinally assessed.", "doi": "10.1186/s12889-023-16945-5", "pmid": "37891509", "labels": {"Funder: VR": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10612288"}, {"db": "pii", "key": "10.1186/s12889-023-16945-5"}], "notes": [], "created": "2023-11-01T13:33:27.833Z", "modified": "2023-11-02T07:22:42.743Z"}, {"entity": "publication", "iuid": "2232c85abf2b4e13ae16b60025ee1d92", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2232c85abf2b4e13ae16b60025ee1d92.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2232c85abf2b4e13ae16b60025ee1d92"}}, "title": "Outcomes of SARS-CoV-2 Omicron Variant Infections Compared with Seasonal Influenza and Respiratory Syncytial Virus Infections in Adults Attending the Emergency Department: A Multicentre Cohort Study.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P", "orcid": "0000-0003-3153-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd6af5accfc84ff9a81983a5ab6683aa.json"}}, {"family": "Karlsson Valik", "given": "John", "initials": "J", "orcid": "0000-0002-4521-1886", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eac431272ad4d8eb13c8d56ddef182c.json"}}, {"family": "Abdel Halim", "given": "Lina", "initials": "L"}, {"family": "Alfv\u00e9n", "given": "Tobias", "initials": "T", "orcid": "0000-0002-2328-3512", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3851560b984401780a380ab1262cd8b.json"}}, {"family": "Naucler", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2023-10-26", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "issn-l": "1058-4838", "volume": null, "issue": null, "pages": null}, "abstract": "There is a controversy over the impact of SARS-CoV-2 infections in an era of less virulent variants and an increasing population immunity. We compared outcomes in adults attending the emergency department (ED) with an Omicron, influenza, or respiratory syncytial virus (RSV) infection.\r\n\r\nRetrospective multicentre cohort study including adults attending the ED in six acute care hospitals in Stockholm County, Sweden, with an Omicron, influenza, or RSV infection during 2021-22 and 2015-19. During 2021-22, patients were tested for all three viruses by multiplex PCR testing. The primary outcome was 30-day all-cause mortality. Secondary outcomes were 90-day all-cause mortality, hospitalization, and intensive care unit (ICU) admission.\r\n\r\nA total of 6,385 patients from 2021-22 were included in the main analyses: 4,833 Omicron, 1,099 influenza, and 453 RSV. The 30-day mortality was 7.9% (n=381) in the Omicron, 2.5% (n=28) in the influenza, and 6.0% (n=27) in the RSV cohort. Patients with Omicron had an adjusted 30-day mortality odds ratio (OR) of 2.36 (95% confidence interval [CI] 1.60-3.62) compared with influenza and 1.42 (95% CI 0.94-2.21) compared with RSV. Among unvaccinated Omicron patients, stronger associations were observed compared with both influenza (OR 5.51 [95% CI 3.41-9.18]) and RSV (OR 3.29 [95% CI 2.01-5.56]). Similar trends were observed for secondary outcomes. Findings were consistent in comparisons with 5,709 pre-pandemic influenza 995 RSV patients.\r\n\r\nIn patients attending the ED, infections with Omicron were both more common and associated with more severe outcomes compared with influenza and RSV, in particular among unvaccinated patients.", "doi": "10.1093/cid/ciad660", "pmid": "37883521", "labels": {"Funder: VR": null, "Category: Health": null, "Category: Vaccines": null, "Funder: H2020": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7330559"}], "notes": [], "created": "2023-11-01T13:34:17.238Z", "modified": "2023-11-02T07:47:44.463Z"}, {"entity": "publication", "iuid": "cfcf4b588dcc4cdb8f4ad99979423778", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfcf4b588dcc4cdb8f4ad99979423778.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfcf4b588dcc4cdb8f4ad99979423778"}}, "title": "Cardiovascular dysautonomia in postacute sequelae of SARS-CoV-2 infection.", "authors": [{"family": "St\u00e5hlberg", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0319-6240", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75523cbe45e04142bb03b50707b96804.json"}}, {"family": "Mahdi", "given": "Ali", "initials": "A"}, {"family": "Johansson", "given": "Madeleine", "initials": "M", "orcid": "0000-0001-9057-9148", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f86daf2351f0466f83705bfa26ba0b4a.json"}}, {"family": "Fedorowski", "given": "Artur", "initials": "A", "orcid": "0000-0002-5352-6327", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2ef9375bfba4311868834aec838c8a3.json"}}, {"family": "Olshansky", "given": "Brian", "initials": "B", "orcid": "0000-0002-6044-045X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21da77c6851743e688ce07c56cb0ba75.json"}}], "type": "journal article", "published": "2023-10-25", "journal": {"title": "J Cardiovasc Electrophysiol", "issn": "1540-8167", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Coronavirus disease 2019 (COVID-19) has led to a worldwide pandemic that continues to transform but will not go away. Cardiovascular dysautonomia in postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection has led to persistent symptoms in a large number of patients. Here, we define the condition and its associated symptoms as well as potential mechanisms responsible. We provide a careful and complete overview of the topic addressing novel studies and a generalized approach to the management of individuals with this complex and potentially debilitating problem. We also discuss future research directions and the important knowledge gaps to be addressed in ongoing and planned studies.", "doi": "10.1111/jce.16117", "pmid": "37877234", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:33:10.141Z", "modified": "2023-11-02T07:14:18.246Z"}, {"entity": "publication", "iuid": "2d681a8066d842df8318bbad966b4f7c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d681a8066d842df8318bbad966b4f7c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d681a8066d842df8318bbad966b4f7c"}}, "title": "The role of primary health care in long-term care facilities during the COVID-19 pandemic in 30 European countries: a retrospective descriptive study (Eurodata study).", "authors": [{"family": "Guisado-Clavero", "given": "Marina", "initials": "M", "orcid": "0000-0002-8448-2929", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe6cb00ce6e64ea9ae551a4a65c1093c.json"}}, {"family": "Ares-Blanco", "given": "Sara", "initials": "S", "orcid": "0000-0002-4984-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5929b4be5ff946a2af9b33fde3fb09ec.json"}}, {"family": "Serafini", "given": "Alice", "initials": "A", "orcid": "0000-0002-7396-2839", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dfd0165d3afe49f49370124c8a379a81.json"}}, {"family": "Del Rio", "given": "Lourdes Ramos", "initials": "LR", "orcid": "0000-0003-4850-2053", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/629e28d8cf1d4ba3926ba037e14f5742.json"}}, {"family": "Larrondo", "given": "Ileana Gefaell", "initials": "IG", "orcid": "0000-0002-1635-1003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a6e202b315e4966a1fc58919d4f4e4e.json"}}, {"family": "Fitzgerald", "given": "Louise", "initials": "L", "orcid": "0009-0009-8039-3097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54a11aeb7912445e91a8861314dc9dc3.json"}}, {"family": "Vinker", "given": "Shlomo", "initials": "S"}, {"family": "van Pottebergh", "given": "Gijs", "initials": "G"}, {"family": "Valtonen", "given": "Kirsi", "initials": "K"}, {"family": "Vaes", "given": "Bert", "initials": "B"}, {"family": "Yilmaz", "given": "Canan Tuz", "initials": "CT"}, {"family": "Torzsa", "given": "P\u00e9ter", "initials": "P"}, {"family": "Tilli", "given": "Paula", "initials": "P"}, {"family": "Sentker", "given": "Theresa", "initials": "T"}, {"family": "Seifert", "given": "Bohumil", "initials": "B"}, {"family": "Saurek-Aleksandrovska", "given": "Natalija", "initials": "N"}, {"family": "Sattler", "given": "Martin", "initials": "M"}, {"family": "Petricek", "given": "Goranka", "initials": "G"}, {"family": "Petrazzuoli", "given": "Ferdinando", "initials": "F"}, {"family": "Petek", "given": "Davorina", "initials": "D"}, {"family": "Perj\u00e9s", "given": "\u00c1bel", "initials": "\u00c1"}, {"family": "L\u00f3pez", "given": "Naldy Parodi", "initials": "NP"}, {"family": "Neves", "given": "Ana Luisa", "initials": "AL"}, {"family": "Murauskien\u0117", "given": "Liubov\u0117", "initials": "L"}, {"family": "Lingner", "given": "Heidrun", "initials": "H"}, {"family": "Nessler", "given": "Katarzyna", "initials": "K"}, {"family": "Heleno", "given": "Bruno", "initials": "B"}, {"family": "Krzto\u0144-Kr\u00f3lewiecka", "given": "Anna", "initials": "A"}, {"family": "Kosti\u0107", "given": "Milena", "initials": "M"}, {"family": "Korkmaz", "given": "B\u00fcsra \u00c7imen", "initials": "B\u00c7"}, {"family": "Kne\u017eevi\u0107", "given": "Sne\u017eana", "initials": "S"}, {"family": "Kirkovski", "given": "Aleksandar", "initials": "A"}, {"family": "Karathanos", "given": "Vasilis Trifon", "initials": "VT"}, {"family": "Jandri\u0107-Ko\u010di\u0107", "given": "Marijana", "initials": "M"}, {"family": "Ivanna", "given": "Shushman", "initials": "S"}, {"family": "\u0406\u043b\u044c\u043a\u043e\u0432", "given": "\u041e\u043a\u0441\u0430\u043d\u0430", "initials": "\u041e"}, {"family": "Hoffmann", "given": "Kathryn", "initials": "K"}, {"family": "Han\u017eeva\u010dki", "given": "Miroslav", "initials": "M"}, {"family": "G\u00f3mez-Johansson", "given": "Mila", "initials": "M"}, {"family": "Gjorgjievski", "given": "Dragan", "initials": "D"}, {"family": "Domeyer", "given": "Philippe-Richard J", "initials": "PJ"}, {"family": "Pe\u00f1a", "given": "Maryher Delphin", "initials": "MD"}, {"family": "Divjak", "given": "Asja \u0106osi\u0107", "initials": "A\u0106"}, {"family": "Busneag", "given": "Iliana-Carmen", "initials": "I"}, {"family": "Brutskaya-Stempkovskaya", "given": "Elena", "initials": "E"}, {"family": "Bayen", "given": "Sabine", "initials": "S"}, {"family": "Bakola", "given": "Maria", "initials": "M"}, {"family": "Adler", "given": "Limor", "initials": "L"}, {"family": "Assenova", "given": "Radost", "initials": "R"}, {"family": "Astier-Pe\u00f1a", "given": "Mar\u00eda Pilar", "initials": "MP", "orcid": "0000-0002-3192-7672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/585b3e1ed7df4d63b0342ab0d96ef9c4.json"}}, {"family": "G\u00f3mez Bravo", "given": "Raquel", "initials": "R"}], "type": "journal article", "published": "2023-10-24", "journal": {"title": "Prim Health Care Res Dev", "issn": "1477-1128", "issn-l": null, "volume": "24", "issue": null, "pages": "e60"}, "abstract": "Primary health care (PHC) supported long-term care facilities (LTCFs) in attending COVID-19 patients. The aim of this study is to describe the role of PHC in LTCFs in Europe during the early phase of the pandemic.\r\n\r\nRetrospective descriptive study from 30 European countries using data from September 2020 collected with an ad hoc semi-structured questionnaire. Related variables are SARS-CoV-2 testing, contact tracing, follow-up, additional testing, and patient care.\r\n\r\nTwenty-six out of the 30 European countries had PHC involvement in LTCFs during the COVID-19 pandemic. PHC participated in initial medical care in 22 countries, while, in 15, PHC was responsible for SARS-CoV-2 test along with other institutions. Supervision of individuals in isolation was carried out mostly by LTCF staff, but physical examination or symptom's follow-up was performed mainly by PHC.\r\n\r\nPHC has participated in COVID-19 pandemic assistance in LTCFs in coordination with LTCF staff, public health officers, and hospitals.", "doi": "10.1017/S1463423623000312", "pmid": "37873623", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10594530"}, {"db": "pii", "key": "S1463423623000312"}], "notes": [], "created": "2023-11-01T13:31:47.959Z", "modified": "2023-11-01T13:48:56.332Z"}, {"entity": "publication", "iuid": "b5f16d32127a4318ba630294e5793728", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5f16d32127a4318ba630294e5793728.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5f16d32127a4318ba630294e5793728"}}, "title": "COVID-19 Recovery: Consistent Absence of Cerebrospinal Fluid Biomarker Abnormalities in Patients With Neurocognitive Post-COVID Complications.", "authors": [{"family": "Kanberg", "given": "Nelly", "initials": "N", "orcid": "0000-0002-1064-995X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84d593bfda8f42688e9d4fe713158679.json"}}, {"family": "Grahn", "given": "Anna", "initials": "A"}, {"family": "Stentoft", "given": "Erika", "initials": "E"}, {"family": "Bremell", "given": "Daniel", "initials": "D"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Studahl", "given": "Marie", "initials": "M"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Sch\u00f6ll", "given": "Michael", "initials": "M", "orcid": "0000-0001-7800-1781", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebf046923a9d4540a7a72578663116f2.json"}}, {"family": "Gostner", "given": "Johanna M", "initials": "JM"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Padmanabhan", "given": "Nikhil", "initials": "N"}, {"family": "Cohen", "given": "Rachel", "initials": "R"}, {"family": "Misaghian", "given": "Salvia", "initials": "S"}, {"family": "Romero", "given": "Daniel", "initials": "D"}, {"family": "Campbell", "given": "Christopher", "initials": "C"}, {"family": "Mathew", "given": "Anu", "initials": "A", "orcid": "0000-0003-3327-3083", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc281597abd2491499abebd7bf90fb20.json"}}, {"family": "Wang", "given": "Mingyue", "initials": "M"}, {"family": "Sigal", "given": "George", "initials": "G", "orcid": "0000-0001-7149-6400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5a9e814e36040718224e726b320c248.json"}}, {"family": "Stengelin", "given": "Martin", "initials": "M"}, {"family": "Ed\u00e9n", "given": "Arvid", "initials": "A", "orcid": "0000-0003-2817-9981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54411b4f4cbe422697c5eb3080c23e2c.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2023-10-24", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899", "volume": null, "issue": null, "pages": null}, "abstract": "To investigate evidence of residual viral infection, intrathecal immune activation, central nervous system (CNS) injury, and humoral responses in cerebrospinal fluid (CSF) and plasma in patients recovering from coronavirus disease 2019 (COVID-19), with or without neurocognitive post-COVID condition (PCC).\r\n\r\nThirty-one participants (25 with neurocognitive PCC) underwent clinical examination, lumbar puncture, and venipuncture \u22653 months after COVID-19 symptom onset. Healthy volunteers were included. CSF and plasma severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid and spike antigen (N-Ag, S-Ag), and CSF biomarkers of immune activation and neuronal injury were analyzed.\r\n\r\nSARS-CoV-2 N-Ag or S-Ag were undetectable in all samples and no participant had pleocytosis. We detected no significant differences in CSF and plasma cytokine concentrations, albumin ratio, IgG index, neopterin, \u03b22M, or in CSF biomarkers of neuronal injury and astrocytic damage. Furthermore, principal component analysis (PCA1) analysis did not indicate any significant differences between the study groups in the marker sets cytokines, neuronal markers, or anti-cytokine autoantibodies.\r\n\r\nWe found no evidence of ongoing viral replication, immune activation, or CNS injury in plasma or CSF in patients with neurocognitive PCC compared with COVID-19 controls or healthy volunteers, suggesting that neurocognitive PCC is a consequence of events suffered during acute COVID-19 rather than persistent viral CNS infection or residual CNS inflammation.", "doi": "10.1093/infdis/jiad395", "pmid": "37874918", "labels": {"Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7328977"}], "notes": [], "created": "2023-11-01T13:31:31.776Z", "modified": "2023-11-01T13:41:08.175Z"}, {"entity": "publication", "iuid": "2817222fdd3a4e4b90b4f90242a904e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2817222fdd3a4e4b90b4f90242a904e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2817222fdd3a4e4b90b4f90242a904e8"}}, "title": "Health-related quality of life after surviving intensive care for COVID-19: a prospective multicenter cohort study.", "authors": [{"family": "Halvorsen", "given": "Peter", "initials": "P"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "H\u00e4stbacka", "given": "Johanna", "initials": "J"}, {"family": "Larsson", "given": "Ing-Marie", "initials": "I"}, {"family": "Eklund", "given": "Rakel", "initials": "R"}, {"family": "Arnberg", "given": "Filip K", "initials": "FK"}, {"family": "Hokkanen", "given": "Laura", "initials": "L"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Wallin", "given": "Ewa", "initials": "E"}, {"family": "Orwelius", "given": "Lotti", "initials": "L"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}], "type": "journal article", "published": "2023-10-21", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "18035"}, "abstract": "In survivors of severe coronavirus disease 2019 (COVID-19) incomplete mental and physical recovery may considerably impact daily activities and health-related quality of life (HRQoL). HRQoL can be evaluated with the RAND-36 questionnaire, a multidimensional instrument that assesses physical and mental aspects of health in eight dimensions. The objective was to investigate HRQoL in intensive care patients previously treated for COVID-19 at three Nordic university hospitals, in a prospective multi-center cohort study. HRQoL was measured using RAND-36, 3-9 months after discharge from intensive care units (ICU). One hospital performed a second follow-up 12 months after discharge. A score under the lower limit of the 95% confidence interval in the reference cohorts was considered as significantly reduced HRQoL. We screened 542 and included 252 patients. There was more than twice as many male (174) as female (78) patients and the median age was 61 (interquartile range, IQR 52-69) years. Hypertension was the most common comorbidity observed in 132 (52%) patients and 121 (48%) patients were mechanically ventilated for a median of 8 (IQR 4-14) days. In RAND-36 physical functioning, physical role functioning, general health (p < 0.001 for all) and social functioning (p < 0.05) were below reference, whereas bodily pain, emotional role functioning and mental health were not. In a time-to-event analysis female sex was associated with a decreased chance of reaching the reference HRQoL in the physical function, bodily pain and mental health dimensions. Higher body mass index was found in the physical functioning dimension and hypertension in the physical functioning, vitality and social functioning dimensions. Similar results were seen for diabetes mellitus in general health, vitality and mental health dimensions, as well as pulmonary illness in the physical role functioning dimension and psychiatric diagnosis in the social functioning dimension. Mechanical ventilation was associated with a decreased likelihood of achieving reference HRQoL in the bodily pain and physical functioning dimensions. Patients treated in an ICU because of COVID-19 had lower HRQoL 3-9 months after ICU discharge than 95% of the general population. Physical dimensions were more severely affected than mental dimensions. Female sex and several comorbidities were associated with a slower rate of recovery.Study registration: clinicaltrials.gov: NCT04316884 registered on the 13th of March 2020, NCT04474249 registered on the 29th of June 2020 and NCT04864938 registered on the 4th of April 2021.", "doi": "10.1038/s41598-023-45346-2", "pmid": "37865685", "labels": {"Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Funder: NordForsk": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10590404"}, {"db": "pii", "key": "10.1038/s41598-023-45346-2"}, {"db": "ClinicalTrials.gov", "key": "NCT04316884"}, {"db": "ClinicalTrials.gov", "key": "NCT04864938"}, {"db": "ClinicalTrials.gov", "key": "NCT04474249"}], "notes": [], "created": "2023-11-01T13:32:33.866Z", "modified": "2023-11-02T07:09:16.017Z"}, {"entity": "publication", "iuid": "c6d57c9e348f451a85788e6e02f86cc5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c6d57c9e348f451a85788e6e02f86cc5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c6d57c9e348f451a85788e6e02f86cc5"}}, "title": "Sex-stratified patterns of emergency cardiovascular admissions prior and during the COVID-19 pandemic.", "authors": [{"family": "Gajewski", "given": "Piotr", "initials": "P"}, {"family": "B\u0142aziak", "given": "Miko\u0142aj", "initials": "M"}, {"family": "Urban", "given": "Szymon", "initials": "S"}, {"family": "Garus", "given": "Mateusz", "initials": "M"}, {"family": "Braunschweig", "given": "Frieder", "initials": "F"}, {"family": "Caldeira", "given": "Daniel", "initials": "D"}, {"family": "Gawor", "given": "Antoni", "initials": "A"}, {"family": "Greenwood", "given": "John P", "initials": "JP"}, {"family": "Guzik", "given": "Mateusz", "initials": "M"}, {"family": "Halfwerk", "given": "Frank R", "initials": "FR"}, {"family": "Iwanek", "given": "Gracjan", "initials": "G"}, {"family": "Jarocki", "given": "Micha\u0142", "initials": "M"}, {"family": "Jura", "given": "Maksym", "initials": "M"}, {"family": "Krzystek-Korpacka", "given": "Ma\u0142gorzata", "initials": "M"}, {"family": "Lewandowski", "given": "\u0141ukasz", "initials": "\u0141"}, {"family": "Lund", "given": "Lars H", "initials": "LH"}, {"family": "Matysiak", "given": "Micha\u0142", "initials": "M"}, {"family": "Pinto", "given": "Fausto", "initials": "F"}, {"family": "Sleziak", "given": "Jakub", "initials": "J"}, {"family": "Wietrzyk", "given": "Weronika", "initials": "W"}, {"family": "Sokolski", "given": "Mateusz", "initials": "M"}, {"family": "Biegus", "given": "Jan", "initials": "J"}, {"family": "Ponikowski", "given": "Piotr", "initials": "P"}, {"family": "Zymli\u0144ski", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2023-10-20", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "17924"}, "abstract": "The COVID-19 pandemic has had a significant impact on global public health, with long-term consequences that are still largely unknown. This study aimed to assess the data regarding acute cardiovascular hospital admissions in five European centers before and during the pandemic. A multicenter, multinational observational registry was created, comparing admissions to the emergency departments during a 3-months period in 2020 (during the pandemic) with the corresponding period in 2019 (pre-pandemic). Data on patient demographics, COVID-19 test results, primary diagnosis, comorbidities, heart failure profile, medication use, and laboratory results were collected. A total of 8778 patients were included in the analysis, with 4447 patients in 2019 and 4331 patients in 2020. The results showed significant differences in the distribution of cardiovascular diseases between the two years. The frequency of pulmonary embolism (PE) increased in 2020 compared to 2019, while acute heart failure (AHF) and other cardiovascular diseases decreased. The odds of PE incidence among hospitalized patients in 2020 were 1.316-fold greater than in 2019. The incidence of AHF was 50.83% less likely to be observed in 2020, and the odds for other cardiovascular diseases increased by 17.42% between the 2 years. Regarding acute coronary syndrome (ACS), the distribution of its types differed between 2019 and 2020, with an increase in the odds of ST-segment elevation myocardial infarction (STEMI) in 2020. Stratification based on sex revealed further insights. Among men, the incidence of AHF decreased in 2020, while other cardiovascular diseases increased. In women, only the incidence of STEMI showed a significant increase. When analyzing the influence of SARS-CoV-2 infection, COVID-positive patients had a higher incidence of PE compared to COVID-negative patients. COVID-positive patients with ACS also exhibited symptoms of heart failure more frequently than COVID-negative patients. These findings provide valuable information on the impact of the COVID-19 pandemic on acute cardiovascular hospital admissions. The increased incidence of PE and changes in the distribution of other cardiovascular diseases highlight the importance of monitoring and managing cardiovascular health during and post pandemic period. The differences observed between sexes emphasize the need for further research to understand potential sex-specific effects of COVID-19 on cardiovascular outcomes.", "doi": "10.1038/s41598-023-44400-3", "pmid": "37864029", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10589214"}, {"db": "pii", "key": "10.1038/s41598-023-44400-3"}], "notes": [], "created": "2023-11-01T13:31:59.668Z", "modified": "2023-11-01T13:52:38.607Z"}, {"entity": "publication", "iuid": "8634058b134c4f2fba1f708de9f6f4d1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8634058b134c4f2fba1f708de9f6f4d1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8634058b134c4f2fba1f708de9f6f4d1"}}, "title": "Exploring the Operational and Technical Changes in the Healthcare Sector During the COVID-19 Pandemic.", "authors": [{"family": "Muzaik", "given": "Suhail", "initials": "S"}, {"family": "Davoody", "given": "Nadia", "initials": "N"}], "type": "journal article", "published": "2023-10-20", "journal": {"title": "Stud Health Technol Inform", "issn": "1879-8365", "issn-l": null, "volume": "309", "issue": null, "pages": "277-281"}, "abstract": "The COVID-19 pandemic has affected the healthcare sector globally including Sweden, creating subsequent operational and technical changes to the wide range of digital healthcare services utilized by healthcare professionals or end consumers. A qualitative study using a self-assessment survey based on the national health services digital maturity assessment was used to study these changes from the perspective of personnel working in Swedish healthcare-related organizations. The number of 30 respondents was selected using purposive sampling, out of them 11 responded. The study highlighted positively perceived changes such as boosting digitalization, improving the procurement process, and introducing crisis management teams. Improving the offered digital services, the tools' effectiveness, efficiency, and technical support were also some of the results. On the contrary, the negatively perceived changes were limiting access to the services, limiting technical support, and reprioritizing non-essential services and projects.", "doi": "10.3233/SHTI230796", "pmid": "37869857", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "SHTI230796"}], "notes": [], "created": "2023-11-01T13:33:54.946Z", "modified": "2023-11-02T07:31:50.682Z"}, {"entity": "publication", "iuid": "f60ebbc57875444e85f44356aacf41f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f60ebbc57875444e85f44356aacf41f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f60ebbc57875444e85f44356aacf41f9"}}, "title": "Dual spatially resolved transcriptomics for human host-pathogen colocalization studies in FFPE tissue sections.", "authors": [{"family": "Sounart", "given": "Hailey", "initials": "H"}, {"family": "L\u00e1z\u00e1r", "given": "Enik\u0151", "initials": "E"}, {"family": "Masarapu", "given": "Yuvarani", "initials": "Y"}, {"family": "Wu", "given": "Jian", "initials": "J"}, {"family": "V\u00e1rkonyi", "given": "Tibor", "initials": "T"}, {"family": "Glasz", "given": "Tibor", "initials": "T"}, {"family": "Kiss", "given": "Andr\u00e1s", "initials": "A"}, {"family": "Borgstr\u00f6m", "given": "Erik", "initials": "E"}, {"family": "Hill", "given": "Andrew", "initials": "A"}, {"family": "Rezene", "given": "Sefanit", "initials": "S"}, {"family": "Gupta", "given": "Soham", "initials": "S"}, {"family": "Jurek", "given": "Aleksandra", "initials": "A"}, {"family": "Niesnerov\u00e1", "given": "Anezka", "initials": "A"}, {"family": "Druid", "given": "Henrik", "initials": "H"}, {"family": "Bergmann", "given": "Olaf", "initials": "O"}, {"family": "Giacomello", "given": "Stefania", "initials": "S", "orcid": "0000-0003-0738-1574", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8bc73b6281054b07880ffbe190731e8b.json"}}], "type": "journal article", "published": "2023-10-19", "journal": {"title": "Genome Biol", "issn": "1474-760X", "issn-l": null, "volume": "24", "issue": "1", "pages": "237"}, "abstract": "Technologies to study localized host-pathogen interactions are urgently needed. Here, we present a spatial transcriptomics approach to simultaneously capture host and pathogen transcriptome-wide spatial gene expression information from human formalin-fixed paraffin-embedded (FFPE) tissue sections at a near single-cell resolution. We demonstrate this methodology in lung samples from COVID-19 patients and validate our spatial detection of SARS-CoV-2 against RNAScope and in situ sequencing. Host-pathogen colocalization analysis identified putative modulators of SARS-CoV-2 infection in human lung cells. Our approach provides new insights into host response to pathogen infection through the simultaneous, unbiased detection of two transcriptomes in FFPE samples.", "doi": "10.1186/s13059-023-03080-y", "pmid": "37858234", "labels": {"Funder: VR": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10588020"}, {"db": "pii", "key": "10.1186/s13059-023-03080-y"}], "notes": [], "created": "2023-11-01T13:31:44.650Z", "modified": "2023-11-01T13:46:37.615Z"}, {"entity": "publication", "iuid": "2f9153d723224d5bbe532af9791850a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2f9153d723224d5bbe532af9791850a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2f9153d723224d5bbe532af9791850a1"}}, "title": "Associations between the COVID-19 pandemic and women's fertility intentions: a multi-country, cross-sectional (I-SHARE) study.", "authors": [{"family": "Zhao", "given": "Min", "initials": "M", "orcid": "0000-0002-2997-2431", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/949b26f15bec49f69f865c784f079101.json"}}, {"family": "O'Hara", "given": "Caitlin Alsandria", "initials": "CA"}, {"family": "Sahril", "given": "Norhafizah Bte", "initials": "NB"}, {"family": "Liu", "given": "Huijun", "initials": "H"}, {"family": "Pei", "given": "Kaiyan", "initials": "K"}, {"family": "Ivanova", "given": "Olena", "initials": "O"}, {"family": "Larsson", "given": "Elin C", "initials": "EC"}, {"family": "Shamu", "given": "Simukai", "initials": "S"}, {"family": "Kpokiri", "given": "Eneyi", "initials": "E"}, {"family": "Cleeve", "given": "Amanda", "initials": "A"}, {"family": "Tucker", "given": "Joseph D", "initials": "JD"}, {"family": "Michielsen", "given": "Kristien", "initials": "K"}, {"family": "Zhang", "given": "Wei-Hong", "initials": "W"}], "type": "journal article", "published": "2023-10-19", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-2009", "issn-l": "2515-1991", "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic, together with the subsequent social distancing measures, could lead to shifts in family and fertility planning. This study aimed to explore the associations between the COVID-19 pandemic and changes in fertility intentions among an international sample of reproductive-aged women.\r\n\r\nA multi-country, cross-sectional study based on data from 10 672 women aged 18-49 years who participated in the International Sexual Health And REproductive Health (I-SHARE) study, which organised an international online survey between July 2020 and February 2021. Factors associated with changes in fertility intentions were explored using multinomial probit regression models. Cluster-robust standard errors were used to calculate model parameters.\r\n\r\nOf 10 672 included reproductive-aged women, 14.4% reported changing their fertility intentions due to the pandemic, with 10.2% postponement and 4.2% acceleration. Women who had ever been isolated/quarantined were more likely to postpone their fertility intentions (adjusted odds ratio (AOR)=1.41; 95% CI 1.18 to 1.69) compared with those who had not; women who lived with a steady partner were more likely to want children sooner (AOR=1.57; 95% CI 1.10 to 2.23) compared with those who did not; and those who reported a higher frequency of getting angry, feeling frustrated, or worrying about their finances were more likely to postpone their fertility intentions. The main findings were robust in the sensitivity analyses.\r\n\r\nMost women who changed fertility intentions because of the pandemic have postponed intentions to expand their families. The pandemic-induced exposures were associated with these postponements.", "doi": "10.1136/bmjsrh-2023-201819", "pmid": "37857464", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjsrh-2023-201819"}], "notes": [], "created": "2023-11-01T13:34:07.164Z", "modified": "2023-11-02T07:41:44.536Z"}, {"entity": "publication", "iuid": "2d38dba1bc134593b8a0bce3328c0c0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d38dba1bc134593b8a0bce3328c0c0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d38dba1bc134593b8a0bce3328c0c0e"}}, "title": "Increased risk of hospitalization, intensive care and death due to COVID-19 in patients with adrenal insufficiency: A Swedish nationwide study.", "authors": [{"family": "Bergthorsdottir", "given": "Ragnhildur", "initials": "R", "orcid": "0000-0002-9535-8632", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eca588e634a2462e9ba1a6558944f240.json"}}, {"family": "Esposito", "given": "Daniela", "initials": "D"}, {"family": "Olsson", "given": "Daniel S", "initials": "DS"}, {"family": "Ragnarsson", "given": "Oskar", "initials": "O", "orcid": "0000-0003-0204-9492", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af4ee421a70e4975885e173d824cbaf2.json"}}, {"family": "Dahlqvist", "given": "Per", "initials": "P"}, {"family": "Bensing", "given": "Sophie", "initials": "S"}, {"family": "N\u00e5tman", "given": "Jonatan", "initials": "J"}, {"family": "Johannsson", "given": "Gudmundur", "initials": "G"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2023-10-18", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Patients with adrenal insufficiency (AI) have excess morbidity and mortality related to infectious disorders. Whether patients with AI have increased morbidity and mortality from COVID-19 is unknown.\r\n\r\nIn this linked Swedish national register-based cohort study, patients with primary and secondary AI diagnosis were identified and followed from 1 January 2020 to 28 February 2021. They were compared with a control cohort from the general population matched 10:1 for age and sex. The following COVID-19 outcomes were studied: incidence of COVID-19 infection, rates of hospitalization, intensive care admission and death. Hazard ratios (HR) with 95% confidence intervals (95% CI) adjusted for socioeconomic factors and comorbidities were estimated using Cox regression analysis.\r\n\r\nWe identified 5430 patients with AI and 54,300 matched controls: There were 47.6% women, mean age was 57.1 (standard deviation 18.1) years, and the frequency of COVID-19 infection was similar, but the frequency of hospitalization (2.1% vs. 0.8%), intensive care (0.3% vs. 0.1%) and death (0.8% vs. 0.2%) for COVID-19 was higher in AI patients than matched controls. After adjustment for socioeconomic factors and comorbidities, the HR (95% CI) was increased for hospitalization (1.96, 1.59-2.43), intensive care admission (2.76, 1.49-5.09) and death (2.29, 1.60-3.28).\r\n\r\nPatients with AI have a similar incidence of COVID-19 infection to a matched control population, but a more than twofold increased risk of developing a severe infection or a fatal outcome. They should therefore be prioritized for vaccination, antiviral therapy and other appropriate treatment to mitigate hospitalization and death.", "doi": "10.1111/joim.13731", "pmid": "37850585", "labels": {"Funder: VR": null, "Funder: Forte": null, "Funder: KAW/SciLifeLab": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:32:09.046Z", "modified": "2023-11-01T13:54:10.428Z"}, {"entity": "publication", "iuid": "5cf9ff158e0c48febb96b8790d6544ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5cf9ff158e0c48febb96b8790d6544ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5cf9ff158e0c48febb96b8790d6544ae"}}, "title": "Age, Successive Waves, Immunization, and Mortality in Elderly COVID-19 Haematological Patients: EPICOVIDEHA Findings.", "authors": [{"family": "Rossi", "given": "Giuseppe", "initials": "G"}, {"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J"}, {"family": "Cattaneo", "given": "Chiara", "initials": "C"}, {"family": "Marchesi", "given": "Francesco", "initials": "F"}, {"family": "D\u00e1vila-Valls", "given": "Julio", "initials": "J"}, {"family": "Mart\u00edn-P\u00e9rez", "given": "Sonia", "initials": "S"}, {"family": "Itri", "given": "Federico", "initials": "F"}, {"family": "L\u00f3pez-Garc\u00eda", "given": "Alberto", "initials": "A"}, {"family": "Glenth\u00f8j", "given": "Andreas", "initials": "A"}, {"family": "Silva", "given": "Maria Gomes DA", "initials": "MGD"}, {"family": "Besson", "given": "Caroline", "initials": "C"}, {"family": "Marchetti", "given": "Monia", "initials": "M"}, {"family": "Weinbergerov\u00e1", "given": "Barbora", "initials": "B"}, {"family": "Jaksic", "given": "Ozren", "initials": "O"}, {"family": "Jim\u00e9nez", "given": "Moraima", "initials": "M"}, {"family": "Bilgin", "given": "Yavuz M", "initials": "YM"}, {"family": "Doesum", "given": "Jaap VAN", "initials": "JV"}, {"family": "Farina", "given": "Francesca", "initials": "F"}, {"family": "\u017d\u00e1k", "given": "Pavel", "initials": "P"}, {"family": "Verga", "given": "Luisa", "initials": "L"}, {"family": "Collins", "given": "Graham P", "initials": "GP"}, {"family": "Bonuomo", "given": "Valentina", "initials": "V"}, {"family": "Praet", "given": "Jens VAN", "initials": "JV"}, {"family": "Nucci", "given": "Marcio", "initials": "M"}, {"family": "Meers", "given": "Stef", "initials": "S"}, {"family": "Espigado", "given": "Ildefonso", "initials": "I"}, {"family": "Fracchiolla", "given": "Nicola S", "initials": "NS"}, {"family": "Valkovi\u0107", "given": "Toni", "initials": "T"}, {"family": "Poulsen", "given": "Christian Bj\u00f8rn", "initials": "CB"}, {"family": "\u010colovi\u0107", "given": "Natasha", "initials": "N"}, {"family": "Dragonetti", "given": "Giulia", "initials": "G"}, {"family": "Ledoux", "given": "Marie-Pierre", "initials": "M"}, {"family": "Tascini", "given": "Carlo", "initials": "C"}, {"family": "Buquicchio", "given": "Caterina", "initials": "C"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Passamonti", "given": "Francesco", "initials": "F"}, {"family": "Machado", "given": "Marina", "initials": "M"}, {"family": "Labrador", "given": "Jorge", "initials": "J"}, {"family": "Duarte", "given": "Rafael F", "initials": "RF"}, {"family": "Sch\u00f6nlein", "given": "Martin", "initials": "M"}, {"family": "Prezioso", "given": "Lucia", "initials": "L"}, {"family": "Falces-Romero", "given": "Iker", "initials": "I"}, {"family": "Kulasekararaj", "given": "Austin", "initials": "A"}, {"family": "Garcia-Vidal", "given": "Carolina", "initials": "C"}, {"family": "Fern\u00e1ndez", "given": "Noem\u00ed", "initials": "N"}, {"family": "Abu-Zeinah", "given": "Ghaith", "initials": "G"}, {"family": "Ormazabal-V\u00e9lez", "given": "Irati", "initials": "I"}, {"family": "Ad\u017ei\u0107-Vuki\u010devi\u0107", "given": "Tatjana", "initials": "T"}, {"family": "Piukovics", "given": "Kl\u00e1ra", "initials": "K"}, {"family": "Stoma", "given": "Igor", "initials": "I"}, {"family": "Cuccaro", "given": "Annarosa", "initials": "A"}, {"family": "Magliano", "given": "Gabriele", "initials": "G"}, {"family": "Szotkowski", "given": "Tom\u00e1\u0161", "initials": "T"}, {"family": "Gonz\u00e1lez-L\u00f3pez", "given": "Tom\u00e1s-Jos\u00e9", "initials": "T"}, {"family": "El-Ashwah", "given": "Shaimaa", "initials": "S"}, {"family": "Bergantim", "given": "Rui", "initials": "R"}, {"family": "Sili", "given": "Uluhan", "initials": "U"}, {"family": "Maertens", "given": "Johan", "initials": "J"}, {"family": "Demirkan", "given": "Fatih", "initials": "F"}, {"family": "Ram\u00f3n", "given": "Cristina DE", "initials": "CD"}, {"family": "Petzer", "given": "Verena", "initials": "V"}, {"family": "Principe", "given": "Maria Ilaria Del", "initials": "MID"}, {"family": "Navr\u00e1til", "given": "Milan", "initials": "M"}, {"family": "Dargenio", "given": "Michelina", "initials": "M"}, {"family": "Seval", "given": "Guldane Cengiz", "initials": "GC"}, {"family": "Samarkos", "given": "Michail", "initials": "M"}, {"family": "R\u00e1\u010dil", "given": "Zden\u011bk", "initials": "Z"}, {"family": "Pincz\u00e9s", "given": "L\u00e1szl\u00f3 Imre", "initials": "LI"}, {"family": "Lahmer", "given": "Tobias", "initials": "T"}, {"family": "Busca", "given": "Alessandro", "initials": "A"}, {"family": "M\u00e9ndez", "given": "Gustavo-Adolfo", "initials": "G"}, {"family": "Vena", "given": "Antonio", "initials": "A"}, {"family": "Biernat", "given": "Monika M", "initials": "MM"}, {"family": "Merelli", "given": "Maria", "initials": "M"}, {"family": "Calbacho", "given": "Maria", "initials": "M"}, {"family": "Bara\u0107", "given": "Aleksandra", "initials": "A"}, {"family": "Bavastro", "given": "Martina", "initials": "M"}, {"family": "Limongelli", "given": "Alessandro", "initials": "A"}, {"family": "Ilhan", "given": "Osman", "initials": "O"}, {"family": "Wolf", "given": "Dominik", "initials": "D"}, {"family": "\u00c7olak", "given": "G\u00f6k\u00e7e Melis", "initials": "GM"}, {"family": "Garc\u00eda-Sanz", "given": "Ram\u00f3n", "initials": "R"}, {"family": "Emarah", "given": "Ziad", "initials": "Z"}, {"family": "Mi\u0161kovi\u0107", "given": "Bojana", "initials": "B"}, {"family": "Gr\u00e4fe", "given": "Stefanie", "initials": "S"}, {"family": "Mladenovi\u0107", "given": "Milo\u0161", "initials": "M"}, {"family": "Aiello", "given": "Tommaso Francesco", "initials": "TF"}, {"family": "N\u00fa\u00f1ez-Mart\u00edn-Buitrago", "given": "Luc\u00eda", "initials": "L"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Arellano", "given": "Elena", "initials": "E"}, {"family": "Zambrotta", "given": "Giovanni Paolo Maria", "initials": "GPM"}, {"family": "Ammatuna", "given": "Emanuele", "initials": "E"}, {"family": "Cabirta", "given": "Alba", "initials": "A"}, {"family": "Sacchi", "given": "Maria Vittoria", "initials": "MV"}, {"family": "Rodrigues", "given": "Raquel Nunes", "initials": "RN"}, {"family": "Hersby", "given": "Ditte Stampe", "initials": "DS"}, {"family": "Hanakova", "given": "Michaela", "initials": "M"}, {"family": "Rahimli", "given": "Laman", "initials": "L"}, {"family": "Cordoba", "given": "Raul", "initials": "R"}, {"family": "Cornely", "given": "Oliver A", "initials": "OA"}, {"family": "Pagano", "given": "Livio", "initials": "L"}], "type": "journal article", "published": "2023-10-18", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": null, "issue": null, "pages": null}, "abstract": "Elderly patients with haematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection impact in different age groups remains unstudied in detail.\r\n\r\nWe analysed elderly patients (age groups: 65-70, 71-75, 76-80 and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with haematological malignancy.\r\n\r\nThe study included data from 3,603 elderly patients (aged 65 or older) with haematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukaemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment.\r\n\r\nThese data underscore the heterogeneity of elderly haematological patients, highlight the different impact of COVID waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts.", "doi": "10.1016/j.ijid.2023.10.013", "pmid": "37863310", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(23)00749-X"}], "notes": [], "created": "2023-11-01T13:33:15.755Z", "modified": "2023-11-02T07:16:55.345Z"}, {"entity": "publication", "iuid": "44585b5eb5754910bf3b4e4c6b78b8b8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44585b5eb5754910bf3b4e4c6b78b8b8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44585b5eb5754910bf3b4e4c6b78b8b8"}}, "title": "SARS-CoV-2 evolution in the Omicron era.", "authors": [{"family": "Roemer", "given": "Cornelius", "initials": "C", "orcid": "0000-0002-6138-6539", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cd1cc85b51147fd8aeef3e206f995b3.json"}}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ", "orcid": "0000-0002-0227-5636", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a612a313d5874131ba64d9811a5d4a08.json"}}, {"family": "Hisner", "given": "Ryan", "initials": "R", "orcid": "0000-0001-8296-9373", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73c65e0c64794ba4a6ada6cf6d927102.json"}}, {"family": "Gueli", "given": "Federico", "initials": "F"}, {"family": "Sakaguchi", "given": "Hitoshi", "initials": "H"}, {"family": "Frohberg", "given": "Nicholas", "initials": "N"}, {"family": "Schoenmakers", "given": "Josette", "initials": "J"}, {"family": "Sato", "given": "Kenta", "initials": "K"}, {"family": "O'Toole", "given": "\u00c1ine", "initials": "\u00c1", "orcid": "0000-0001-8083-474X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4faf78c4ee04495b98b3fd8ef32a0a78.json"}}, {"family": "Rambaut", "given": "Andrew", "initials": "A", "orcid": "0000-0003-4337-3707", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d25e62e17c243f3ab72304ca504e296.json"}}, {"family": "Pybus", "given": "Oliver G", "initials": "OG"}, {"family": "Ruis", "given": "Christopher", "initials": "C", "orcid": "0000-0003-0977-5534", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02edb07284dc438b883cb404c615942f.json"}}, {"family": "Murrell", "given": "Ben", "initials": "B", "orcid": "0000-0002-0393-4445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60dac9ecf84d4eb3b90fb4ee1298bc52.json"}}, {"family": "Peacock", "given": "Thomas P", "initials": "TP", "orcid": "0000-0001-7077-2928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/940835adb42b431a882f9af9acf166f7.json"}}], "type": "journal article", "published": "2023-10-16", "journal": {"title": "Nat Microbiol", "issn": "2058-5276", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Since SARS-CoV-2 BA.5 (Omicron) emerged and spread in 2022, Omicron lineages have markedly diversified. Here we review the evolutionary trajectories and processes that underpin the emergence of these lineages, and identify the most prevalent sublineages. We discuss the potential origins of second-generation BA.2 lineages. Simple and complex recombination, antigenic drift and convergent evolution have enabled SARS-CoV-2 to accumulate mutations that alter its antigenicity. We also discuss the potential evolutionary trajectories of SARS-CoV-2 in the future.", "doi": "10.1038/s41564-023-01504-w", "pmid": "37845314", "labels": {"Category: Genomics & transcriptomics": null, "Type: Other": null, "Funder: KAW/SciLifeLab": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41564-023-01504-w"}], "notes": [], "created": "2023-11-01T13:33:52.276Z", "modified": "2023-11-02T07:30:16.619Z"}, {"entity": "publication", "iuid": "980940116302415bb1ddd8726ee46d69", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/980940116302415bb1ddd8726ee46d69.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/980940116302415bb1ddd8726ee46d69"}}, "title": "EuCARE-hospitalised study protocol: a cohort study of patients hospitalised with COVID-19 in the EuCARE project.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P"}, {"family": "Varisco", "given": "Benedetta", "initials": "B"}, {"family": "Bai", "given": "Francesca", "initials": "F"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Naucler", "given": "Pontus", "initials": "P"}, {"family": "Pfeifer", "given": "Nico", "initials": "N"}, {"family": "Cozzi-Lepri", "given": "Alessandro", "initials": "A"}, {"family": "Ceccherini-Silberstein", "given": "Francesca", "initials": "F"}, {"family": "Naumovas", "given": "Daniel", "initials": "D"}, {"family": "Drobniewski", "given": "Francis", "initials": "F"}, {"family": "Jensen", "given": "Bj\u00f6rn-Erik Ole", "initials": "BO"}, {"family": "Toscano", "given": "Cristina", "initials": "C"}, {"family": "Parczewski", "given": "Mi\u0142osz", "initials": "M"}, {"family": "Quintanares", "given": "Gibran Horemheb Rubio", "initials": "GHR"}, {"family": "Mwau", "given": "Matilu", "initials": "M"}, {"family": "Pinto", "given": "Jorge A", "initials": "JA"}, {"family": "Incardona", "given": "Francesca", "initials": "F"}, {"family": "Mommo", "given": "Chiara", "initials": "C"}, {"family": "Marchetti", "given": "Giulia", "initials": "G"}], "type": "clinical trial protocol", "published": "2023-10-16", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "issn-l": null, "volume": "23", "issue": "1", "pages": "690"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), can lead to hospitalisation, particularly in elderly, immunocompromised, and non-vaccinated or partially vaccinated individuals. Although vaccination provides protection, the duration of this protection wanes over time. Additional doses can restore immunity, but the influence of viral variants, specific sequences, and vaccine-induced immune responses on disease severity remains unclear. Moreover, the efficacy of therapeutic interventions during hospitalisation requires further investigation. The study aims to analyse the clinical course of COVID-19 in hospitalised patients, taking into account SARS-CoV-2 variants, viral sequences, and the impact of different vaccines. The primary outcome is all-cause in-hospital mortality, while secondary outcomes include admission to intensive care unit and length of stay, duration of hospitalisation, and the level of respiratory support required.\r\n\r\nThis ongoing multicentre study observes hospitalised adult patients with confirmed SARS-CoV-2 infection, utilising a combination of retrospective and prospective data collection. It aims to gather clinical and laboratory variables from around 35,000 patients, with potential for a larger sample size. Data analysis will involve biostatistical and machine-learning techniques. Selected patients will provide biological material. The study started on October 14, 2021 and is scheduled to end on October 13, 2026.\r\n\r\nThe analysis of a large sample of retrospective and prospective data about the acute phase of SARS CoV-2 infection in hospitalised patients, viral variants and vaccination in several European and non-European countries will help us to better understand risk factors for disease severity and the interplay between SARS CoV-2 variants, immune responses and vaccine efficacy. The main strengths of this study are the large sample size, the long study duration covering different waves of COVID-19 and the collection of biological samples that allows future research.\r\n\r\nThe trial has been registered on ClinicalTrials.gov. The unique identifier assigned to this trial is NCT05463380.", "doi": "10.1186/s12879-023-08658-2", "pmid": "37845624", "labels": {"Category: Health": null, "Funder: H2020": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10580565"}, {"db": "pii", "key": "10.1186/s12879-023-08658-2"}, {"db": "ClinicalTrials.gov", "key": "NCT05463380"}], "notes": [], "created": "2023-11-01T13:31:41.491Z", "modified": "2023-11-01T13:45:05.813Z"}, {"entity": "publication", "iuid": "2045217c9d5b4df2968b59d7905ac27e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2045217c9d5b4df2968b59d7905ac27e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2045217c9d5b4df2968b59d7905ac27e"}}, "title": "Design, structure and plasma binding of ancestral \u03b2-CoV scaffold antigens.", "authors": [{"family": "Hueting", "given": "David", "initials": "D"}, {"family": "Schriever", "given": "Karen", "initials": "K", "orcid": "0000-0002-3677-5508", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/437c22b7bd0344bfa62968e70d0a9ddf.json"}}, {"family": "Sun", "given": "Rui", "initials": "R"}, {"family": "Vlachiotis", "given": "Stelios", "initials": "S"}, {"family": "Zuo", "given": "Fanglei", "initials": "F", "orcid": "0000-0002-4545-1265", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11312f803b4f49d6be77684a634b0caf.json"}}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Persson", "given": "Helena", "initials": "H"}, {"family": "Hofstr\u00f6m", "given": "Camilla", "initials": "C"}, {"family": "Ohlin", "given": "Mats", "initials": "M", "orcid": "0000-0002-5105-1938", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/def6c0678dfd48ea9a1255a8a00e7ebc.json"}}, {"family": "Walld\u00e9n", "given": "Karin", "initials": "K"}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Marcotte", "given": "Harold", "initials": "H", "orcid": "0000-0002-7168-349X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e05b7b044674cc08cd2269ccf8c076e.json"}}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q", "orcid": "0000-0003-1990-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94a32366862b470eba3a15521b9be290.json"}}, {"family": "Andr\u00e9ll", "given": "Juni", "initials": "J", "orcid": "0000-0003-2313-9155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4088371e089f452783d302617a7fac91.json"}}, {"family": "Syr\u00e9n", "given": "Per-Olof", "initials": "P"}], "type": "journal article", "published": "2023-10-16", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "14", "issue": "1", "pages": "6527"}, "abstract": "We report the application of ancestral sequence reconstruction on coronavirus spike protein, resulting in stable and highly soluble ancestral scaffold antigens (AnSAs). The AnSAs interact with plasma of patients recovered from COVID-19 but do not bind to the human angiotensin-converting enzyme 2 (ACE2) receptor. Cryo-EM analysis of the AnSAs yield high resolution structures (2.6-2.8 \u00c5) indicating a closed pre-fusion conformation in which all three receptor-binding domains (RBDs) are facing downwards. The structures reveal an intricate hydrogen-bonding network mediated by well-resolved loops, both within and across monomers, tethering the N-terminal domain and RBD together. We show that AnSA-5 can induce and boost a broad-spectrum immune response against the wild-type RBD as well as circulating variants of concern in an immune organoid model derived from tonsils. Finally, we highlight how AnSAs are potent scaffolds by replacing the ancestral RBD with the wild-type sequence, which restores ACE2 binding and increases the interaction with convalescent plasma.", "doi": "10.1038/s41467-023-42200-x", "pmid": "37845250", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC10579346"}, {"db": "pii", "key": "10.1038/s41467-023-42200-x"}], "notes": [], "created": "2023-11-01T13:33:34.835Z", "modified": "2023-11-02T14:11:11.290Z"}, {"entity": "publication", "iuid": "9e6701a55fc64fdf88baada957443056", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9e6701a55fc64fdf88baada957443056.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9e6701a55fc64fdf88baada957443056"}}, "title": "Boosted production of antibodies which neutralized different SARS-CoV-2 variants in a COVID-19 convalescent following mRNA vaccination - a case study.", "authors": [{"family": "Ravlo", "given": "Erlend", "initials": "E"}, {"family": "Ianevski", "given": "Aleksandr", "initials": "A"}, {"family": "Starheim", "given": "Eirin", "initials": "E"}, {"family": "Wang", "given": "Wei", "initials": "W"}, {"family": "Ji", "given": "Ping", "initials": "P"}, {"family": "Lysvand", "given": "Hilde", "initials": "H"}, {"family": "Smura", "given": "Teemu", "initials": "T"}, {"family": "Kivi", "given": "Gaily", "initials": "G"}, {"family": "Voolaid", "given": "Maia-Liisa", "initials": "M"}, {"family": "Plaan", "given": "Kati", "initials": "K"}, {"family": "Ustav", "given": "Mart", "initials": "M"}, {"family": "Zusinaite", "given": "Eva", "initials": "E"}, {"family": "Tenson", "given": "Tanel", "initials": "T"}, {"family": "Kurg", "given": "Reet", "initials": "R"}, {"family": "Oksenych", "given": "Valentyn", "initials": "V"}, {"family": "Walstad", "given": "Kirsti", "initials": "K"}, {"family": "Nordb\u00f8", "given": "Svein Arne", "initials": "SA"}, {"family": "Kaarb\u00f8", "given": "Mari", "initials": "M"}, {"family": "Ernits", "given": "Karin", "initials": "K"}, {"family": "Bj\u00f8r\u00e5s", "given": "Magnar", "initials": "M"}, {"family": "Kainov", "given": "Denis E", "initials": "DE"}, {"family": "H\u00f8ys\u00e6ter Fenstad", "given": "Mona", "initials": "M"}], "type": "case reports", "published": "2023-10-16", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": null, "issue": null, "pages": null}, "abstract": "Vaccinated convalescents do not develop severe COVID-19 after infection with new SARS-CoV-2 variants. We questioned how mRNA vaccination of convalescents provides protection from emerging virus variant. From the cohort of 71 convalescent plasma donors, we identified a patient who developed immune response to infection with SARS-CoV-2 variant of 20A clade and who subsequently received mRNA vaccine encoding S protein of strain of 19A clade. We showed that vaccination increased the production of immune cells and anti-S antibodies in the serum. Serum antibodies neutralized not only 19A and 20A, but also 20B, 20H, 21J and 21K virus variants. One of the serum antibodies (100F8) completely neutralized 20A, 21J and partially 21K strains. 100F8 was structurally similarly to published Ab188 antibody, which recognized non-conserved epitope on the S protein. We proposed that 100F8 and other serum antibodies of the patient which recognized non- and conserved epitopes of the S protein, could have additive or synergistic effect to neutralize various virus variants. Thus, mRNA vaccination could be beneficial for convalescents because it boosts production of neutralizing antibodies with broad-spectrum activity. -.", "doi": "10.1016/j.ijid.2023.10.011", "pmid": "37852599", "labels": {"Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(23)00748-8"}], "notes": [], "created": "2023-11-01T13:32:11.722Z", "modified": "2023-11-01T13:55:02.083Z"}, {"entity": "publication", "iuid": "0444ca3518ef4347aed3ff1988d9f5b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0444ca3518ef4347aed3ff1988d9f5b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0444ca3518ef4347aed3ff1988d9f5b2"}}, "title": "Measures against COVID-19 affected the spread of human enteric viruses in a Swedish community, as found when monitoring wastewater.", "authors": [{"family": "Wang", "given": "Hao", "initials": "H"}, {"family": "Churqui", "given": "Marianela Patzi", "initials": "MP"}, {"family": "Tunovic", "given": "Timur", "initials": "T"}, {"family": "Enache", "given": "Lucica", "initials": "L"}, {"family": "Johansson", "given": "Anette", "initials": "A"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Norder", "given": "Hel\u00e9ne", "initials": "H"}], "type": "journal article", "published": "2023-10-15", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "issn-l": "0048-9697", "volume": "895", "issue": null, "pages": "165012"}, "abstract": "The quantification of viral genomes in wastewater reflects the prevalence of viral infections within the community. Knowledge of how the spread of common enteric viruses in the community was affected by the Swedish COVID-19 interventions is limited. To investigate this, the weekly wastewater samples collected for monitoring SARS-CoV-2 throughout the COVID-19 pandemic at the Rya sewage treatment plant in Gothenburg were also analyzed for adenovirus, norovirus GII, astrovirus, and rotavirus. The amount of each viral genome was quantified by real-time-qPCR and compared with the quantity of these viral genomes in wastewater from 2017. The results showed that the winter seasonality of norovirus GII and rotavirus in wastewater observed in 2017 was interrupted shortly after the introduction of the COVID-19 interventions, and they remained at low level throughout the pandemic. The circulation pattern of astrovirus and adenovirus was less affected. When the COVID-19 restrictions were lifted in 2022, a dramatic increase was observed in the amount of norovirus GII, rotavirus, and adenovirus genomes in wastewater. The changes in abundance and seasonality of some viruses identified through wastewater monitoring were consistent with changes in the number of patients diagnosed with these viruses. These findings suggest that moderate intervention to prevent COVID-19 significantly reduced the spread of some enteric viruses in the community. The results show that wastewater monitoring is a valuable tool for detecting the spread and outbreaks of viral infections that may cause gastroenteritis also when people do not seek medical help, such as during the COVID-19 pandemic.", "doi": "10.1016/j.scitotenv.2023.165012", "pmid": "37353026", "labels": {"Category: Public Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10284612"}, {"db": "pii", "key": "S0048-9697(23)03635-5"}], "notes": [], "created": "2023-10-04T09:29:53.367Z", "modified": "2023-10-04T09:41:30.000Z"}, {"entity": "publication", "iuid": "3760d53d668c48d4a6913a27074e84b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3760d53d668c48d4a6913a27074e84b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3760d53d668c48d4a6913a27074e84b9"}}, "title": "Umbilical cord clamping in the early phases of the COVID-19 era - A systematic review and meta-analysis of reported practice and recommendations in guidelines.", "authors": [{"family": "Berg", "given": "Johan", "initials": "J"}, {"family": "Thies-Lagergren", "given": "Li", "initials": "L"}, {"family": "Svedenkrans", "given": "Jenny", "initials": "J"}, {"family": "Samkutty", "given": "Jeremiah", "initials": "J"}, {"family": "Larsson", "given": "Sara Marie", "initials": "SM"}, {"family": "Mercer", "given": "Judith S", "initials": "JS"}, {"family": "Rabe", "given": "Heike", "initials": "H"}, {"family": "Andersson", "given": "Ola", "initials": "O"}, {"family": "Zaigham", "given": "Mehreen", "initials": "M"}], "type": "journal article", "published": "2023-10-13", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": null, "issue": null, "pages": null}, "abstract": "In the beginning of the COVID-19 pandemic, delayed umbilical cord clamping (CC) at birth may have been commonly discouraged despite a lack of convincing evidence of mother-to-neonate SARS-CoV-2 transmission. We aimed to systematically review guidelines, reports of practice and to analyze associations between timing of cord clamping and mother-to-neonate SARS-CoV-2 transmission during the early phases of the pandemic.\r\n\r\nMajor databases were searched December 1, 2019 to July 20, 2021.\r\n\r\nstudies and guidelines describing cord clamping practice in women with SARS-CoV-2 infection during pregnancy until two postnatal days, giving birth to live born neonates.\r\n\r\nno extractable data. Two reviewers independently screened studies for eligibility and assessed study quality. Pooled prevalence rates were calculated.\r\n\r\nForty-eight studies (1476 neonates) and 40 guidelines were included. Delayed CC was recommended in 70.0% of the guidelines. Nevertheless, delayed CC was reported less often than early CC: 262/1476 (17.8%) vs. 511/1476 (34.6%). Neonatal SARS-CoV-2 positivity rates were similar following delayed (1.2%) and early CC (1.3%). Most SARS-CoV-2 transmissions (93.3%) occurred in utero.\r\n\r\nDelayed CC did not seem to increase mother-to-neonate SARS-CoV-2 transmission. Due to its benefits, it should be encouraged even in births where the mother has a SARS-CoV-2 infection.", "doi": "10.1016/j.ijid.2023.10.010", "pmid": "37839504", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(23)00747-6"}], "notes": [], "created": "2023-11-01T13:31:51.574Z", "modified": "2023-11-01T13:49:55.161Z"}, {"entity": "publication", "iuid": "041ca07d2c3b4051a87a5ad6910b6b2f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/041ca07d2c3b4051a87a5ad6910b6b2f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/041ca07d2c3b4051a87a5ad6910b6b2f"}}, "title": "A community effort in SARS-CoV-2 drug discovery.", "authors": [{"family": "Schimunek", "given": "Johannes", "initials": "J"}, {"family": "Seidl", "given": "Philipp", "initials": "P"}, {"family": "Elez", "given": "Katarina", "initials": "K"}, {"family": "Hempel", "given": "Tim", "initials": "T"}, {"family": "Le", "given": "Tuan", "initials": "T"}, {"family": "No\u00e9", "given": "Frank", "initials": "F"}, {"family": "Olsson", "given": "Simon", "initials": "S"}, {"family": "Raich", "given": "Llu\u00eds", "initials": "L"}, {"family": "Winter", "given": "Robin", "initials": "R"}, {"family": "Gokcan", "given": "Hatice", "initials": "H"}, {"family": "Gusev", "given": "Filipp", "initials": "F"}, {"family": "Gutkin", "given": "Evgeny M", "initials": "EM"}, {"family": "Isayev", "given": "Olexandr", "initials": "O"}, {"family": "Kurnikova", "given": "Maria G", "initials": "MG"}, {"family": "Narangoda", "given": "Chamali H", "initials": "CH"}, {"family": "Zubatyuk", "given": "Roman", "initials": "R"}, {"family": "Bosko", "given": "Ivan P", "initials": "IP"}, {"family": "Furs", "given": "Konstantin V", "initials": "KV"}, {"family": "Karpenko", "given": "Anna D", "initials": "AD"}, {"family": "Kornoushenko", "given": "Yury V", "initials": "YV"}, {"family": "Shuldau", "given": "Mikita", "initials": "M"}, {"family": "Yushkevich", "given": "Artsemi", "initials": "A"}, {"family": "Benabderrahmane", "given": "Mohammed", "initials": "M"}, {"family": "Bousquet-Melou", "given": "Patrick", "initials": "P"}, {"family": "Bureau", "given": "Ronan", "initials": "R"}, {"family": "Charton", "given": "Beatrice", "initials": "B"}, {"family": "Cirou", "given": "Bertrand", "initials": "B"}, {"family": "Gil", "given": "G\u00e9rard", "initials": "G"}, {"family": "Allen", "given": "William J", "initials": "WJ"}, {"family": "Sirimulla", "given": "Suman", "initials": "S"}, {"family": "Watowich", "given": "Stanley", "initials": "S"}, {"family": "Antonopoulos", "given": "Nick", "initials": "N"}, {"family": "Epitropakis", "given": "Nikolaos", "initials": "N"}, {"family": "Krasoulis", "given": "Agamemnon", "initials": "A"}, {"family": "Pitsikalis", "given": "Vassilis", "initials": "V"}, {"family": "Theodorakis", "given": "Stavros", "initials": "S"}, {"family": "Kozlovskii", "given": "Igor", "initials": "I"}, {"family": "Maliutin", "given": "Anton", "initials": "A"}, {"family": "Medvedev", "given": "Alexander", "initials": "A"}, {"family": "Popov", "given": "Petr", "initials": "P"}, {"family": "Zaretckii", "given": "Mark", "initials": "M"}, {"family": "Eghbal-Zadeh", "given": "Hamid", "initials": "H"}, {"family": "Halmich", "given": "Christina", "initials": "C"}, {"family": "Hochreiter", "given": "Sepp", "initials": "S"}, {"family": "Mayr", "given": "Andreas", "initials": "A"}, {"family": "Ruch", "given": "Peter", "initials": "P"}, {"family": "Widrich", "given": "Michael", "initials": "M"}, {"family": "Berenger", "given": "Francois", "initials": "F"}, {"family": "Kumar", "given": "Ashutosh", "initials": "A"}, {"family": "Yamanishi", "given": "Yoshihiro", "initials": "Y"}, {"family": "Zhang", "given": "Kam", "initials": "K"}, {"family": "Bengio", "given": "Emmanuel", "initials": "E"}, {"family": "Bengio", "given": "Yoshua", "initials": "Y"}, {"family": "Jain", "given": "Moksh", "initials": "M"}, {"family": "Korablyov", "given": "Maksym", "initials": "M"}, {"family": "Liu", "given": "Cheng-Hao", "initials": "CH"}, {"family": "Gilles", "given": "Marcous", "initials": "M"}, {"family": "Glaab", "given": "Enrico", "initials": "E"}, {"family": "Barnsley", "given": "Kelly", "initials": "K"}, {"family": "Iyengar", "given": "Suhasini M", "initials": "SM"}, {"family": "Ondrechen", "given": "Mary Jo", "initials": "MJ"}, {"family": "Haupt", "given": "V Joachim", "initials": "VJ"}, {"family": "Kaiser", "given": "Florian", "initials": "F"}, {"family": "Schroeder", "given": "Michael", "initials": "M"}, {"family": "Pugliese", "given": "Luisa", "initials": "L"}, {"family": "Albani", "given": "Simone", "initials": "S"}, {"family": "Athanasiou", "given": "Christina", "initials": "C"}, {"family": "Beccari", "given": "Andrea", "initials": "A"}, {"family": "Carloni", "given": "Paolo", "initials": "P"}, {"family": "D'Arrigo", "given": "Giulia", "initials": "G"}, {"family": "Gianquinto", "given": "Eleonora", "initials": "E"}, {"family": "Go\u00dfen", "given": "Jonas", "initials": "J"}, {"family": "Hanke", "given": "Anton", "initials": "A"}, {"family": "Joseph", "given": "Benjamin P", "initials": "BP"}, {"family": "Kokh", "given": "Daria B", "initials": "DB"}, {"family": "Kovachka", "given": "Sandra", "initials": "S"}, {"family": "Manelfi", "given": "Candida", "initials": "C"}, {"family": "Mukherjee", "given": "Goutam", "initials": "G"}, {"family": "Mu\u00f1iz-Chicharro", "given": "Abraham", "initials": "A"}, {"family": "Musiani", "given": "Francesco", "initials": "F"}, {"family": "Nunes-Alves", "given": "Ariane", "initials": "A"}, {"family": "Paiardi", "given": "Giulia", "initials": "G"}, {"family": "Rossetti", "given": "Giulia", "initials": "G"}, {"family": "Sadiq", "given": "S Kashif", "initials": "SK"}, {"family": "Spyrakis", "given": "Francesca", "initials": "F"}, {"family": "Talarico", "given": "Carmine", "initials": "C"}, {"family": "Tsengenes", "given": "Alexandros", "initials": "A"}, {"family": "Wade", "given": "Rebecca", "initials": "R"}, {"family": "Copeland", "given": "Conner", "initials": "C"}, {"family": "Gaiser", "given": "Jeremiah", "initials": "J"}, {"family": "Olson", "given": "Daniel R", "initials": "DR"}, {"family": "Roy", "given": "Amitava", "initials": "A"}, {"family": "Venkatraman", "given": "Vishwesh", "initials": "V"}, {"family": "Wheeler", "given": "Travis J", "initials": "TJ"}, {"family": "Arthanari", "given": "Haribabu", "initials": "H"}, {"family": "Blaschitz", "given": "Klara", "initials": "K"}, {"family": "Cespugli", "given": "Marco", "initials": "M"}, {"family": "Durmaz", "given": "Vedat", "initials": "V"}, {"family": "Fackeldey", "given": "Konstantin", "initials": "K"}, {"family": "Fischer", "given": "Patrick D", "initials": "PD"}, {"family": "Gorgulla", "given": "Christoph", "initials": "C"}, {"family": "Gruber", "given": "Christian", "initials": "C"}, {"family": "Gruber", "given": "Karl", "initials": "K"}, {"family": "Hetmann", "given": "Michael", "initials": "M"}, {"family": "Kinney", "given": "Jamie E", "initials": "JE"}, {"family": "Das", "given": "Krishna M Padmanabha", "initials": "KMP"}, {"family": "Pandita", "given": "Shreya", "initials": "S"}, {"family": "Singh", "given": "Amit", "initials": "A"}, {"family": "Steinkellner", "given": "Georg", "initials": "G"}, {"family": "Tesseyre", "given": "Guilhem", "initials": "G"}, {"family": "Wagner", "given": "Gerhard", "initials": "G"}, {"family": "Wang", "given": "Zi-Fu", "initials": "ZF"}, {"family": "Yust", "given": "Ryan J", "initials": "RJ"}, {"family": "Druzhilovskiy", "given": "Dmitry S", "initials": "DS"}, {"family": "Filimonov", "given": "Dmitry", "initials": "D"}, {"family": "Pogodin", "given": "Pavel V", "initials": "PV"}, {"family": "Poroikov", "given": "Vladimir", "initials": "V"}, {"family": "Rudik", "given": "Anastassia V", "initials": "AV"}, {"family": "Stolbov", "given": "Leonid A", "initials": "LA"}, {"family": "Veselovsky", "given": "Alexander V", "initials": "AV"}, {"family": "De Rosa", "given": "Maria", "initials": "M"}, {"family": "Simone", "given": "Giada De", "initials": "G"}, {"family": "Gulotta", "given": "Maria R", "initials": "MR"}, {"family": "Lombino", "given": "Jessica", "initials": "J"}, {"family": "Mekni", "given": "Nedra", "initials": "N"}, {"family": "Perricone", "given": "Ugo", "initials": "U"}, {"family": "Casini", "given": "Arturo", "initials": "A"}, {"family": "Embree", "given": "Amanda", "initials": "A"}, {"family": "Gordon", "given": "D Benjamin", "initials": "DB"}, {"family": "Lei", "given": "David", "initials": "D"}, {"family": "Pratt", "given": "Katelin", "initials": "K"}, {"family": "Voigt", "given": "Christopher A", "initials": "CA"}, {"family": "Chen", "given": "Kuang-Yu", "initials": "KY"}, {"family": "Jacob", "given": "Yves", "initials": "Y"}, {"family": "Krischuns", "given": "Tim", "initials": "T"}, {"family": "Lafaye", "given": "Pierre", "initials": "P"}, {"family": "Zettor", "given": "Agn\u00e8s", "initials": "A"}, {"family": "Rodr\u00edguez", "given": "M Luis", "initials": "ML"}, {"family": "White", "given": "Kris M", "initials": "KM"}, {"family": "Fearon", "given": "Daren", "initials": "D"}, {"family": "von Delft", "given": "Frank", "initials": "F"}, {"family": "Walsh", "given": "Martin A", "initials": "MA"}, {"family": "Horvath", "given": "Dragos", "initials": "D"}, {"family": "Brooks", "given": "Charles L", "initials": "CL"}, {"family": "Falsafi", "given": "Babak", "initials": "B"}, {"family": "Ford", "given": "Bryan", "initials": "B"}, {"family": "Garc\u00eda-Sastre", "given": "Adolfo", "initials": "A"}, {"family": "Lee", "given": "Sang Yup", "initials": "SY"}, {"family": "Naffakh", "given": "Nadia", "initials": "N"}, {"family": "Varnek", "given": "Alexandre", "initials": "A"}, {"family": "Klambauer", "given": "Guenter", "initials": "G"}, {"family": "Hermans", "given": "Thomas M", "initials": "TM"}], "type": "journal article", "published": "2023-10-13", "journal": {"title": "Mol Inform", "issn": "1868-1751", "issn-l": null}, "abstract": "The COVID-19 pandemic continues to pose a substantial threat to human lives and is likely to do so for years to come. Despite the availability of vaccines, searching for efficient small-molecule drugs that are widely available, including in low- and middle-income countries, is an ongoing challenge. In this work, we report the results of an open science community effort, the \"Billion molecules against Covid-19 challenge\", to identify small-molecule inhibitors against SARS-CoV-2 or relevant human receptors. Participating teams used a wide variety of computational methods to screen a minimum of 1 billion virtual molecules against 6 protein targets. Overall, 31 teams participated, and they suggested a total of 639,024 molecules, which were subsequently ranked to find 'consensus compounds'. The organizing team coordinated with various contract research organizations (CROs) and collaborating institutions to synthesize and test 878 compounds for biological activity against proteases (Nsp5, Nsp3, TMPRSS2), nucleocapsid N, RdRP (only the Nsp12 domain), and (alpha) spike protein S. Overall, 27 compounds with weak inhibition/binding were experimentally identified by binding-, cleavage-, and/or viral suppression assays and are presented here. Open science approaches such as the one presented here contribute to the knowledge base of future drug discovery efforts in finding better SARS-CoV-2 treatments.", "doi": "10.1002/minf.202300262", "pmid": "37833243", "labels": [], "xrefs": [], "notes": [], "created": "2023-11-01T13:31:54.098Z", "modified": "2023-11-01T13:31:54.163Z"}, {"entity": "publication", "iuid": "f28d86a7fc294a118412007f577700be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f28d86a7fc294a118412007f577700be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f28d86a7fc294a118412007f577700be"}}, "title": "Obstetric Intervention and Perinatal Outcomes During the Coronavirus Disease 2019 (COVID-19) Pandemic.", "authors": [{"family": "Simon", "given": "Sophie", "initials": "S"}, {"family": "John", "given": "Sid", "initials": "S"}, {"family": "Lisonkova", "given": "Sarka", "initials": "S"}, {"family": "Razaz", "given": "Neda", "initials": "N"}, {"family": "Muraca", "given": "Giulia M", "initials": "GM"}, {"family": "Boutin", "given": "Am\u00e9lie", "initials": "A"}, {"family": "Bedaiwy", "given": "Mohamed A", "initials": "MA"}, {"family": "Brandt", "given": "Justin S", "initials": "JS"}, {"family": "Ananth", "given": "Cande V", "initials": "CV"}, {"family": "Joseph", "given": "K S", "initials": "KS"}], "type": "journal article", "published": "2023-10-12", "journal": {"title": "Obstet Gynecol", "issn": "1873-233X", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To quantify pandemic-related changes in obstetric intervention and perinatal outcomes in the United States.\r\n\r\nWe carried out a retrospective study of all live births and fetal deaths in the United States, 2015-2021, with data obtained from the natality, fetal death, and linked live birth-infant death files of the National Center for Health Statistics. Analyses were carried out among all singletons; singletons of patients with prepregnancy diabetes, prepregnancy hypertension, and hypertensive disorders of pregnancy; and twins. Outcomes of interest included preterm birth, preterm labor induction or preterm cesarean delivery, macrosomia, postterm birth, and perinatal death. Interrupted time series analyses were used to estimate changes in the prepandemic period (January 2015-February 2020), at pandemic onset (March 2020), and in the pandemic period (March 2020-December 2021).\r\n\r\nThe study population included 26,604,392 live births and 155,214 stillbirths. The prepandemic period was characterized by temporal increases in preterm birth and preterm labor induction or cesarean delivery rates and temporal reductions in macrosomia, postterm birth, and perinatal mortality. Pandemic onset was associated with absolute decreases in preterm birth (decrease of 0.322/100 live births, 95% CI 0.506-0.139) and preterm labor induction or cesarean delivery (decrease of 0.190/100 live births, 95% CI 0.334-0.047) and absolute increases in macrosomia (increase of 0.046/100 live births), postterm birth (increase of 0.015/100 live births), and perinatal death (increase of 0.501/1,000 total births, 95% CI 0.220-0.783). These changes were larger in subpopulations at high risk (eg, among singletons of patients with prepregnancy diabetes). Among singletons of patients with prepregnancy diabetes, pandemic onset was associated with a decrease in preterm birth (decrease of 1.634/100 live births) and preterm labor induction or cesarean delivery (decrease of 1.521/100 live births) and increases in macrosomia (increase of 0.328/100 live births) and perinatal death (increase of 9.840/1,000 total births, 95% CI 3.933-15.75). Most changes were reversed in the months after pandemic onset.\r\n\r\nThe onset of the coronavirus disease 2019 (COVID-19) pandemic was associated with a transient decrease in obstetric intervention (especially preterm labor induction or cesarean delivery) and a transient increase in perinatal mortality.", "doi": "10.1097/AOG.0000000000005412", "pmid": "37826851", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "00006250-990000000-00925"}], "notes": [], "created": "2023-11-01T13:34:24.628Z", "modified": "2023-11-02T07:52:28.666Z"}, {"entity": "publication", "iuid": "1bc095eacf4642b386c0e6e595d6ec1f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1bc095eacf4642b386c0e6e595d6ec1f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1bc095eacf4642b386c0e6e595d6ec1f"}}, "title": "Persistent SARS-CoV-2 infection in patients with B-cell deficiency: a case series of successful antiviral treatment of four patients.", "authors": [{"family": "Fax\u00e9n", "given": "Lisa", "initials": "L"}, {"family": "Edvinsson", "given": "Marie", "initials": "M"}], "type": "case reports", "published": "2023-10-11", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "issn-l": "0300-9734", "volume": "128", "issue": null, "pages": null}, "abstract": "Persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in immunocompromised patients remains a major medical challenge. Diagnosing the syndrome is difficult as symptoms may mimic other diseases and treatment guidelines are lacking. We describe a case series of four patients with persistent SARS-CoV-2 infection that all had an underlying B-cell deficiency due to rituximab treatment (in one case in combination with epcoritamab). In all four patients, it was initially difficult to recognize the persistent disease, leading to a duration of illness between 45 and 242 days. Two patients were only positive for SARS-CoV-2 by polymerase chain reaction (PCR) in the nasopharynx at the beginning of the disease but were later repeatedly negative. However, when bronchoalveolar lavage was performed, a positive SARS-CoV-2 PCR was revealed from the lower airways in both patients. The difficulties establishing diagnosis contributed to these two patients' long disease course. The longest disease duration was in the patient treated with rituximab and epcoritamab, who also responded poorly to single standard antiviral treatment. This patient ultimately cleared the infection after administering a combination treatment with remdesivir and nirmatrelvir/ritonavir. After a confirmed diagnosis, the other three patients cleared the infection when they were finally treated with antivirals. Increasing clinicians' awareness of this condition is important as it might be treatable once diagnosed. Further studies are warranted to define the condition and treatment strategy with greater precision.", "doi": "10.48101/ujms.v128.9807", "pmid": "37849689", "labels": {"Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10578053"}, {"db": "pii", "key": "9807"}], "notes": [], "created": "2023-11-01T13:33:25.248Z", "modified": "2023-11-02T07:20:19.184Z"}, {"entity": "publication", "iuid": "634a7e09497f47248acffc706bc8c203", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/634a7e09497f47248acffc706bc8c203.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/634a7e09497f47248acffc706bc8c203"}}, "title": "Changing patterns in the burden of paediatric injuries during the COVID-19 pandemic: a study in Mozambique's central hospitals.", "authors": [{"family": "Amado", "given": "Vanda", "initials": "V", "orcid": "0000-0002-8839-984X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e564fcb429b45c8932476d0df8d086f.json"}}, {"family": "Trott", "given": "Sebastien", "initials": "S"}, {"family": "M\u00f6ller", "given": "Jette", "initials": "J"}, {"family": "Couto", "given": "Maria Tereza", "initials": "MT"}, {"family": "Wallis", "given": "Lee", "initials": "L"}, {"family": "Laflamme", "given": "Lucie", "initials": "L"}], "type": "journal article", "published": "2023-10-06", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "issn-l": null, "volume": "23", "issue": "1", "pages": "1071"}, "abstract": "There is a substantial body of knowledge on the effects of the COVID-19 pandemic on injuries showing frequent but inconsistent reductions in both volume and pattern. Yet, studies specifically addressing children are less common, not least from low- and middle-income countries. This study investigated whether changes in the pattern and outcome of paediatric injury admissions to Mozambique's four regional referral hospitals during 2020.\r\n\r\nClinical charts of paediatric patients presenting to the targeted hospitals with acute injuries were reviewed using a set of child, injury, and outcome characteristics during each of two consecutive restriction periods in 2020 using as a comparator the same periods in 2019, the year before the pandemic. Differences between 2020 and 2019 proportions for any characteristic were examined using the t-test (significance level 0.05).\r\n\r\nDuring both restriction periods, compared with the previous year, reductions in the number of injuries were noticed in nearly all aspects investigated, albeit more remarkably during the first restriction period, in particular, greater proportions of injuries in the home setting and from burns (7.2% and 11.5% respectively) and a reduced one of discharged patients (by 2.5%).\r\n\r\nDuring the restrictions implemented to contend the pandemic in Mozambique in 2020, although each restriction period saw a drop in the volume of injury admissions at central hospitals, the pattern of child, injury and outcome characteristics did not change much, except for an excess of home and burn injuries in the first, more restrictive period. Whether this reflects the nature of the restrictions only or, rather, other mechanisms that came into play, individual or health systems related, remains to be determined.", "doi": "10.1186/s12913-023-10073-x", "pmid": "37803444", "labels": {"Category: Social Science & Humanities": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10559493"}, {"db": "pii", "key": "10.1186/s12913-023-10073-x"}], "notes": [], "created": "2023-11-01T13:34:09.824Z", "modified": "2023-11-02T07:42:56.476Z"}, {"entity": "publication", "iuid": "0c9b00c1c1354d5a86afaba702538d56", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c9b00c1c1354d5a86afaba702538d56.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c9b00c1c1354d5a86afaba702538d56"}}, "title": "COVID-19 vaccine booster doses provide increased protection against COVID-19 hospitalization compared with previously vaccinated individuals: Interim findings from the REFORCO-Brazil real-world effectiveness study during Delta and Omicron.", "authors": [{"family": "Meeraus", "given": "Wilhelmine", "initials": "W"}, {"family": "Stuurman", "given": "Anke L", "initials": "AL"}, {"family": "Durukal", "given": "Ilgaz", "initials": "I"}, {"family": "Conde-Sousa", "given": "Eduardo", "initials": "E"}, {"family": "Lee", "given": "Andrew", "initials": "A"}, {"family": "Maria", "given": "Andr\u00e9 Santa", "initials": "AS"}, {"family": "Furtado", "given": "B\u00e1rbara Emoingt", "initials": "BE"}, {"family": "Ouwens", "given": "Mario", "initials": "M"}, {"family": "Gray", "given": "Christen M", "initials": "CM"}, {"family": "Valverde", "given": "Douglas Andreas", "initials": "DA"}, {"family": "da Silva", "given": "Hugo Gomes", "initials": "HG"}, {"family": "Taylor", "given": "Sylvia", "initials": "S"}], "type": "journal article", "published": "2023-10-06", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null, "volume": "41", "issue": "42", "pages": "6366-6378"}, "abstract": "Although COVID-19 booster vaccination is widely recommended, there is limited long-term, population-level, real-world evidence on the magnitude of improved protection against severe COVID-19 conferred by boosting with monovalent COVID-19 vaccines developed against ancestral SARS-CoV-2, especially in low- or middle-income countries. We present interim results from the first large-scale assessment of the relative vaccine effectiveness (rVE) of first and second booster doses against severe COVID-19 in a low-/middle-income country.\r\n\r\nREFORCO-Brazil is an ongoing, test-negative case-control study (NCT05697705) utilizing Brazil national severe acute respiratory syndrome (SARS) surveillance and vaccination data. In SARS hospitalizations from August 1, 2021 to July 31, 2022, we matched test-positive (via SARS-CoV-2 antigen/reverse transcription polymerase chain reaction [RT-PCR]) cases and test-negative case-controls (via RT-PCR) based on admission date, preceding vaccinations, and age. We evaluated the rVEs of four monovalent COVID-19 vaccines (AZD1222, Ad26.COV2.S, CoronaVac, and BNT162b2) as second boosters compared with any first boosters received \u22654 months previously, and as first boosters compared with primary-series vaccinations completed \u22654 months previously.\r\n\r\nThe overall rVE of second boosters, from 5668 (2238 test-positive) evaluated hospitalizations, was 24.7 % (95 % confidence interval [CI]: 12.6-35.1); the overall rVE of first boosters, from 30,272 (12,063 test-positive) hospitalizations, was 46.8 % (95 % CI: 43.3-50.0). The rVEs of AZD1222 and BNT162b2 were similar: 29.4 % (95 % CI: 8.6-45.5) and 25.5 % (95 % CI: 4.2-42.2), respectively, for second boosters; and 42.5 % (95 % CI: 28.0-54.0) and 50.8 % (95 % CI: 47.5-54.0), respectively, for first boosters. In general, rVEs were higher in elderly (\u226580 years) and immunocompromised/high-risk individuals.\r\n\r\nOur results support the use of AZD1222 and other adenoviral/mRNA vaccine boosters to maintain protection against COVID-19 hospitalization from Omicron subvariants, including in elderly and immunocompromised individuals at increased risk of accelerated waning or severe outcomes.", "doi": "10.1016/j.vaccine.2023.08.085", "pmid": "37704499", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(23)01051-4"}], "notes": [], "created": "2023-10-06T06:52:27.599Z", "modified": "2023-10-06T09:13:58.218Z"}, {"entity": "publication", "iuid": "cb04059790e140e3aacb27d3654f89c2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cb04059790e140e3aacb27d3654f89c2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cb04059790e140e3aacb27d3654f89c2"}}, "title": "Seizures in hospitalised paediatric patients with SARS-CoV-2 and comparison of severity with seizures in hospitalised paediatric patients with other respiratory viruses during the COVID-19 pandemic: a population-based cohort study.", "authors": [{"family": "Anastasopoulou", "given": "Stavroula", "initials": "S", "orcid": "0000-0002-4210-0064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/649861ba67894cba90ec4340f5bc07a3.json"}}, {"family": "Svensson", "given": "Eva", "initials": "E"}, {"family": "Wickstr\u00f6m", "given": "Ronny", "initials": "R"}, {"family": "Hertting", "given": "Olof", "initials": "O"}, {"family": "Rinder", "given": "Malin Ryd", "initials": "MR"}, {"family": "Bennet", "given": "Rutger", "initials": "R"}, {"family": "Eriksson", "given": "Margareta", "initials": "M"}], "type": "journal article", "published": "2023-10-05", "journal": {"title": "Arch Dis Child", "issn": "1468-2044", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To study seizures in patients hospitalised due to SARS-CoV-2 infection, and compare their severity with seizures in patients hospitalised due to other viral respiratory tract infections (RTIs).\r\n\r\nObservational population-based cohort study.\r\n\r\nNorthern Stockholm.\r\n\r\nPatients aged 1 month-18 years hospitalised due to SARS-CoV-2 with and without seizures, and patients of the same age hospitalised due to other viral RTIs with seizures, between 1 March 2020 and 30 June 2022.\r\n\r\nThe prevalence of seizures in hospitalised patients due to SARS-CoV-2, the evaluation of assumed predictors of seizures and the comparison of severity markers in patients with SARS-CoV-2 versus other RTIs.\r\n\r\n32 of 239 included patients (13.4%) admitted due to SARS-CoV-2 infection had seizures. Central nervous system (CNS) disease and the omicron period had significantly increased OR for seizures (OR: 5.12; CI: 2.06 to 12.72 and OR: 3.01; CI: 1.15 to 7.88, respectively). Seizures in patients with SARS-CoV-2 were more common in children older than 5 years (p=0.001), even in the absence of fever (p=0.007), as compared with other viral RTIs. The duration of hospitalisation was longer in patients with seizures due to other viral RTIs (p=0.023). There was no significant difference regarding severity markers of seizures between the two groups.\r\n\r\nCNS disease and the omicron period were risk factors for seizures in patients with SARS-CoV-2, who were older than patients with other RTIs. The severity of seizures was comparable between the two groups; hospitalisation was however longer in patients with other RTIs.", "doi": "10.1136/archdischild-2023-325974", "pmid": "37798081", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "archdischild-2023-325974"}], "notes": [], "created": "2023-11-01T13:32:30.834Z", "modified": "2023-11-02T07:08:08.817Z"}, {"entity": "publication", "iuid": "9c74268f95a24e3ebf847acd863c1c28", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9c74268f95a24e3ebf847acd863c1c28.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9c74268f95a24e3ebf847acd863c1c28"}}, "title": "Extracellular vesicles in plasma and cerebrospinal fluid in patients with COVID-19 and neurological symptoms.", "authors": [{"family": "Taxiarchis", "given": "Apostolos", "initials": "A", "orcid": "0000-0003-2137-715X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c141f0b728747da86c5a682a77eeed3.json"}}, {"family": "Bellander", "given": "Bo-Michael", "initials": "B"}, {"family": "Antovic", "given": "Jovan", "initials": "J"}, {"family": "Soutari", "given": "Nida", "initials": "N"}, {"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Karakoyun", "given": "Can", "initials": "C"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Antovic", "given": "Aleksandra", "initials": "A"}], "type": "journal article", "published": "2023-10-05", "journal": {"title": "Int J Lab Hematol", "issn": "1751-553X", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Increased levels of extracellular vesicles (EVs) are associated with haemostatic disturbances in various clinical settings. However, their role in COVID-19 patients is still not fully clear. In the present study we investigated EVs in plasma from patients with COVID-19 and neurological symptoms in relation to the activation of coagulation.\r\n\r\nNineteen COVID-19 patients with neurological symptoms and twenty-three aged-matched healthy individuals were included. Global coagulation assays were performed and levels of EVs were determined by flow-cytometry in plasma and cerebrospinal fluid (CSF).\r\n\r\nA procoagulant state characterized by significantly increased overall coagulation- (OCP) and overall haemostatic potential (OHP), diminished overall fibrinolytic potential (OFP) together with a denser fibrin structure was found in patients with COVID-19. Flow cytometry revealed elevated levels of plasma circulating EVs derived from neutrophils (MPO+) and platelets (CD61+), as well as EVs expressing phosphatidylserine (PS+) and complement component C5b-9 (TCC+) in patients with COVID-19 compared with controls. The concentrations of PS+, CD61+ and TCC+ EVs were positively correlated with OCP and OHP in COVID-19 patients. Moreover, we identified CD61+, MPO+ and endothelial cell-derived EVs, as well as EVs exposing PS and TCC in the CSF of patients suffering from neurological symptoms during COVID-19.\r\n\r\nThe unique finding in this study was the presence of EVs in the CSF of COVID-19 patients with neurologic manifestations as well as higher expression of complement protein on circulating plasma EVs. EVs may indicate blood-brain barrier damage during SARS-COV-2 infection.", "doi": "10.1111/ijlh.14182", "pmid": "37795549", "labels": {"Funder: KAW/SciLifeLab": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:31:35.468Z", "modified": "2023-11-01T13:42:24.975Z"}, {"entity": "publication", "iuid": "0e323a2c2ff247e589894e18a5dda5f6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e323a2c2ff247e589894e18a5dda5f6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e323a2c2ff247e589894e18a5dda5f6"}}, "title": "Habitual short sleepers with pre-existing medical conditions are at higher risk of Long COVID.", "authors": [{"family": "Berezin", "given": "Linor", "initials": "L"}, {"family": "Waseem", "given": "Rida", "initials": "R"}, {"family": "Merikanto", "given": "Ilona", "initials": "I"}, {"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L"}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Korman", "given": "Maria", "initials": "M"}, {"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "Espie", "given": "Colin", "initials": "C"}, {"family": "Landtblom", "given": "Anne-Marie", "initials": "A"}, {"family": "Penzel", "given": "Thomas", "initials": "T"}, {"family": "Matsui", "given": "Kentaro", "initials": "K"}, {"family": "Hrubos-Str\u00f8m", "given": "Harald", "initials": "H"}, {"family": "Mota-Rolim", "given": "S\u00e9rgio", "initials": "S"}, {"family": "Nadorff", "given": "Michael R", "initials": "MR"}, {"family": "Plazzi", "given": "Giuseppe", "initials": "G"}, {"family": "Reis", "given": "Catia", "initials": "C"}, {"family": "Chan", "given": "Rachel Ngan Yin", "initials": "RNY"}, {"family": "Cunha", "given": "Ana Suely", "initials": "AS"}, {"family": "Yordanova", "given": "Juliana", "initials": "J"}, {"family": "Bjelajac", "given": "Adrijana Koscec", "initials": "AK"}, {"family": "Inoue", "given": "Yuichi", "initials": "Y"}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "Chung", "given": "Frances", "initials": "F"}], "type": "journal article", "published": "2023-10-03", "journal": {"title": "J Clin Sleep Med", "issn": "1550-9397", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Preliminary evidence suggests that the risk of Long COVID is higher among people with pre-existing medical conditions. Based on its proven adjuvant role in immunity, habitual sleep duration may alter the risk for developing Long COVID. The objective of this study was to determine whether the odds of Long COVID are higher amongst those with pre-existing medical conditions, and whether the strength of this association varies by habitual sleep duration.\r\n\r\nUsing data from 13,461 respondents from 16 countries who participated in the 2021 survey based International COVID Sleep Study II (ICOSS II), we studied the associations between habitual sleep duration, pre-existing medical conditions, and Long COVID.\r\n\r\nOf 2,508 individuals who had COVID-19, 61% reported at least one Long COVID symptom. Multivariable logistic regression analysis showed that the risk of having Long COVID was 1.8-fold higher for average-length sleepers (6-9h/night) with pre-existing medical conditions compared to those without pre-existing medical conditions [aOR 1.84 (1.18-2.90), P=0.008]. The risk of Long COVID was 3-fold higher for short sleepers with pre-existing medical conditions [aOR 2.95 (1.04-8.4), P=0.043] and not significantly higher for long sleepers with pre-existing conditions [aOR 2.11 (0.93-4.77), P=0.073] compared to average-length sleepers without pre-existing conditions.\r\n\r\nHabitual short nighttime sleep duration exacerbated the risk of Long COVID in individuals with pre-existing conditions. Restoring nighttime sleep to average duration represents a potentially modifiable behavioral factor to lower the odds of Long COVID for at-risk patients.", "doi": "10.5664/jcsm.10818", "pmid": "37858285", "labels": {"Category: Health": null, "Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:34:19.743Z", "modified": "2023-11-02T07:48:57.999Z"}, {"entity": "publication", "iuid": "8d078daade6a478fabf0a33c296442e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d078daade6a478fabf0a33c296442e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d078daade6a478fabf0a33c296442e7"}}, "title": "A retrospective multicenter cohort study of the association between anti-Factor Xa values and death, thromboembolism, and bleeding in patients with critical COVID-19.", "authors": [{"family": "Jonmarker", "given": "Sandra", "initials": "S", "orcid": "0000-0001-5836-8594", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d28ab27b84f40e2b3d57c91595ece92.json"}}, {"family": "Litorell", "given": "Jacob", "initials": "J"}, {"family": "Alarcon", "given": "Felix", "initials": "F"}, {"family": "Al-Abani", "given": "Kais", "initials": "K", "orcid": "0000-0002-1789-1538", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a63c8ea9d2b4263817a82795ff41e55.json"}}, {"family": "Bj\u00f6rkman", "given": "Sofia", "initials": "S"}, {"family": "Farm", "given": "Maria", "initials": "M", "orcid": "0000-0003-3696-463X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6de1008608a5480e83cad2a4b1148967.json"}}, {"family": "Grip", "given": "Jonathan", "initials": "J", "orcid": "0000-0001-9735-4160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c335d9cd48e4dd4b193b77e61850257.json"}}, {"family": "S\u00f6derberg", "given": "M\u00e5rten", "initials": "M", "orcid": "0000-0002-1043-3630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/947a6a5a9cf840a0ad95685ed3cbff84.json"}}, {"family": "Hollenberg", "given": "Jacob", "initials": "J", "orcid": "0000-0002-3100-9716", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa5fcdb83dfb4b2db965edaa7cdec033.json"}}, {"family": "Wahlin", "given": "Rebecka Rubenson", "initials": "RR", "orcid": "0000-0003-3890-8236", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac398b363ac24711ba64957e9b5d1940.json"}}, {"family": "Kander", "given": "Thomas", "initials": "T", "orcid": "0000-0002-5404-2981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a22b3691ec6c4b8ebe4b4a15ca9e4b02.json"}}, {"family": "Rimling", "given": "Liivi", "initials": "L"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J", "orcid": "0000-0001-8739-7896", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c2fb174ab842c8809900877de8c008.json"}}, {"family": "Joelsson-Alm", "given": "Eva", "initials": "E", "orcid": "0000-0002-9041-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07a091265e654b21bc27fa14b93e4ec0.json"}}, {"family": "Dahlberg", "given": "Martin", "initials": "M", "orcid": "0000-0002-1271-8736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27361cedab254730be4df04b4df64a77.json"}}, {"family": "Cronhjort", "given": "Maria", "initials": "M", "orcid": "0000-0002-0444-8553", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/198af039066341ac8538d5e9b9ea9e32.json"}}], "type": "journal article", "published": "2023-10-02", "journal": {"title": "Thromb J", "issn": "1477-9560", "issn-l": null, "volume": "21", "issue": "1", "pages": "101"}, "abstract": "Patients with critical COVID-19 have a high risk of thromboembolism, but intensified thromboprophylaxis has not been proven beneficial. The activity of low-molecular-weight heparins can be monitored by measuring anti-Factor Xa. We aimed to study the association between anti-Factor Xa values and death, thromboembolism, and bleeding in patients with critical COVID-19.\r\n\r\nThis retrospective cohort study included adult patients with critical COVID-19 admitted to an intensive care unit at three Swedish hospitals between March 2020 and May 2021 with at least one valid peak and/or trough anti-Factor Xa value. Within the peak and trough categories, patients' minimum, median, and maximum values were determined. Logistic regressions with splines were used to assess associations.\r\n\r\nIn total, 408 patients had at least one valid peak and/or trough anti-Factor Xa measurement, resulting in 153 patients with peak values and 300 patients with trough values. Lower peak values were associated with thromboembolism for patients' minimum (p = 0.01), median (p = 0.005) and maximum (p = 0.001) values. No association was seen between peak values and death or bleeding. Higher trough values were associated with death for median (p = 0.03) and maximum (p = 0.002) values and with both bleeding (p = 0.01) and major bleeding (p = 0.02) for maximum values, but there were no associations with thromboembolism.\r\n\r\nMeasuring anti-Factor Xa activity may be relevant for administrating low-molecular-weight heparin to patients with critical COVID-19. Lower peak values were associated with an increased risk of thromboembolism, and higher trough values were associated with an increased risk of death and bleeding. Prospective studies are needed to confirm the results.\r\n\r\nThe study was retrospectively registered at Clinicaltrials.gov, NCT05256524, February 24, 2022.", "doi": "10.1186/s12959-023-00541-z", "pmid": "37784131", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10544466"}, {"db": "pii", "key": "10.1186/s12959-023-00541-z"}, {"db": "ClinicalTrials.gov", "key": "NCT05256524"}], "notes": [], "created": "2023-11-01T13:32:16.871Z", "modified": "2023-11-01T13:57:22.624Z"}, {"entity": "publication", "iuid": "2b4e178db7a44c5688dcaff545589bae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b4e178db7a44c5688dcaff545589bae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b4e178db7a44c5688dcaff545589bae"}}, "title": "Clinical standards for diagnosis, treatment and prevention of post-COVID-19 lung disease.", "authors": [{"family": "Visca", "given": "D", "initials": "D"}, {"family": "Centis", "given": "R", "initials": "R"}, {"family": "Pontali", "given": "E", "initials": "E"}, {"family": "Zampogna", "given": "E", "initials": "E"}, {"family": "Russell", "given": "A-M", "initials": "A"}, {"family": "Migliori", "given": "G B", "initials": "GB"}, {"family": "Andrejak", "given": "C", "initials": "C"}, {"family": "Aro", "given": "M", "initials": "M"}, {"family": "Bayram", "given": "H", "initials": "H"}, {"family": "Berkani", "given": "K", "initials": "K"}, {"family": "Bruchfeld", "given": "J", "initials": "J"}, {"family": "Chakaya", "given": "J M", "initials": "JM"}, {"family": "Chorostowska-Wynimko", "given": "J", "initials": "J"}, {"family": "Crestani", "given": "B", "initials": "B"}, {"family": "Dalcolmo", "given": "M P", "initials": "MP"}, {"family": "D'Ambrosio", "given": "L", "initials": "L"}, {"family": "Dinh-Xuan", "given": "A-T", "initials": "A"}, {"family": "Duong-Quy", "given": "S", "initials": "S"}, {"family": "Fernandes", "given": "C", "initials": "C"}, {"family": "Garc\u00eda-Garc\u00eda", "given": "J-M", "initials": "J"}, {"family": "de Melo Kawassaki", "given": "A", "initials": "A"}, {"family": "Carrozzi", "given": "L", "initials": "L"}, {"family": "Martinez-Garcia", "given": "M A", "initials": "MA"}, {"family": "Martins", "given": "P Carreiro", "initials": "PC"}, {"family": "Mirsaeidi", "given": "M", "initials": "M"}, {"family": "Mohammad", "given": "Y", "initials": "Y"}, {"family": "Naidoo", "given": "R N", "initials": "RN"}, {"family": "Neuparth", "given": "N", "initials": "N"}, {"family": "Sese", "given": "L", "initials": "L"}, {"family": "Silva", "given": "D R", "initials": "DR"}, {"family": "Solovic", "given": "I", "initials": "I"}, {"family": "Sooronbaev", "given": "T M", "initials": "TM"}, {"family": "Spanevello", "given": "A", "initials": "A"}, {"family": "Sverzellati", "given": "N", "initials": "N"}, {"family": "Tanno", "given": "L", "initials": "L"}, {"family": "Tiberi", "given": "S", "initials": "S"}, {"family": "Vasankari", "given": "T", "initials": "T"}, {"family": "Vasarmidi", "given": "E", "initials": "E"}, {"family": "Vitacca", "given": "M", "initials": "M"}, {"family": "Annesi-Maesano", "given": "I", "initials": "I"}], "type": "journal article", "published": "2023-10-01", "journal": {"title": "Int J Tuberc Lung Dis", "issn": "1815-7920", "issn-l": null, "volume": "27", "issue": "10", "pages": "729-741"}, "abstract": "BACKGROUND: The aim of these clinical standards is to provide guidance on 'best practice' care for the diagnosis, treatment and prevention of post-COVID-19 lung disease.METHODS: A panel of international experts representing scientific societies, associations and groups active in post-COVID-19 lung disease was identified; 45 completed a Delphi process. A 5-point Likert scale indicated level of agreement with the draft standards. The final version was approved by consensus (with 100% agreement).RESULTS: Four clinical standards were agreed for patients with a previous history of COVID-19: Standard 1, Patients with sequelae not explained by an alternative diagnosis should be evaluated for possible post-COVID-19 lung disease; Standard 2, Patients with lung function impairment, reduced exercise tolerance, reduced quality of life (QoL) or other relevant signs or ongoing symptoms \u22654 weeks after the onset of first symptoms should be evaluated for treatment and pulmonary rehabilitation (PR); Standard 3, The PR programme should be based on feasibility, effectiveness and cost-effectiveness criteria, organised according to local health services and tailored to an individual patient's needs; and Standard 4, Each patient undergoing and completing PR should be evaluated to determine its effectiveness and have access to a counselling/health education session.CONCLUSION: This is the first consensus-based set of clinical standards for the diagnosis, treatment and prevention of post-COVID-19 lung disease. Our aim is to improve patient care and QoL by guiding clinicians, programme managers and public health officers in planning and implementing a PR programme to manage post-COVID-19 lung disease.", "doi": "10.5588/ijtld.23.0248", "pmid": "37749839", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC10519381"}], "notes": [], "created": "2023-10-06T06:56:22.374Z", "modified": "2023-10-06T11:17:11.963Z"}, {"entity": "publication", "iuid": "8ff5d63b7d214c3ca0b2c2fa34c71790", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ff5d63b7d214c3ca0b2c2fa34c71790.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ff5d63b7d214c3ca0b2c2fa34c71790"}}, "title": "Anxiety and depression played a central role in the COVID-19 mental distress: A network analysis.", "authors": [{"family": "Fico", "given": "Giovanna", "initials": "G"}, {"family": "Oliva", "given": "Vincenzo", "initials": "V"}, {"family": "De Prisco", "given": "Michele", "initials": "M"}, {"family": "Fortea", "given": "Lydia", "initials": "L"}, {"family": "Fortea", "given": "Adriana", "initials": "A"}, {"family": "Gim\u00e9nez-Palomo", "given": "Anna", "initials": "A"}, {"family": "Anmella", "given": "Gerard", "initials": "G"}, {"family": "Hidalgo-Mazzei", "given": "Diego", "initials": "D"}, {"family": "Vazquez", "given": "Mireia", "initials": "M"}, {"family": "Gomez-Ramiro", "given": "Marta", "initials": "M"}, {"family": "Carreras", "given": "Bernat", "initials": "B"}, {"family": "Murru", "given": "Andrea", "initials": "A"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Mortier", "given": "Philippe", "initials": "P"}, {"family": "Vilagut", "given": "Gemma", "initials": "G"}, {"family": "Amigo", "given": "Franco", "initials": "F"}, {"family": "Ferrer", "given": "Montse", "initials": "M"}, {"family": "Garc\u00eda-Mieres", "given": "Helena", "initials": "H"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Alonso", "given": "Jordi", "initials": "J"}], "type": "journal article", "published": "2023-10-01", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "issn-l": null, "volume": "338", "issue": null, "pages": "384-392"}, "abstract": "Psychological, socio-demographics, and clinical factors play an important role in patients with COVID-19, but their relationship is complex. The network approach might be used to disentangle complex interactions in different systems. Using data from a multicentre, cross-sectional, survey among patients with COVID-19 in Spain (July-November 2020), we investigated the network structure of mental disorders symptoms, social support, and psychological resilience, and changes in network structures according to the presence of a pre-existing mental disorder or hospitalization for COVID-19.\r\n\r\nSubjects completed a survey to evaluate sociodemographic characteristics, COVID-19 infection status, resilience, social support, and symptoms of depression, anxiety disorders, post-traumatic stress disorder, panic attacks, and substance use disorder. 2084 patients with COVID-19 were included in the analysis. Network analysis was conducted to evaluate network and bridge centrality, and the network properties were compared between COVID-19 patients with and without a history of lifetime mental disorder, and between hospitalized and non-hospitalized patients.\r\n\r\nGeneralization of our findings may be difficult since differences in network connectivity may exist in different populations or samples.\r\n\r\nAnxiety and depression showed high centrality in patients with COVID-19 and anxiety showed the highest bridge influence in the network. Resilience and social support showed a low influence on mental disorder symptoms. Global network estimations show no statistically significant changes between patients with and without pre-existing mental disorders or between hospitalized and non-hospitalized patients.\r\n\r\nAnxiety might be a key treatment target in patients with COVID-19 since its treatment might prevent other mental health adverse outcomes.", "doi": "10.1016/j.jad.2023.06.034", "pmid": "37336249", "labels": {"Category: Social Science & Humanities": null, "Funder: H2020": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10276655"}, {"db": "pii", "key": "S0165-0327(23)00799-1"}], "notes": [], "created": "2023-10-04T09:31:19.003Z", "modified": "2023-10-04T10:48:42.360Z"}, {"entity": "publication", "iuid": "a9399f5eff8949499e9364604ce29b07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a9399f5eff8949499e9364604ce29b07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a9399f5eff8949499e9364604ce29b07"}}, "title": "The use and access to contraception in Sweden during the COVID-19 pandemic period.", "authors": [{"family": "Envall", "given": "Niklas", "initials": "N", "orcid": "0000-0003-2813-7642", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/374e845be5ee48c89221e0d6d3fd6af6.json"}}, {"family": "Gemzell Danielsson", "given": "Kristina", "initials": "K", "orcid": "0000-0001-6516-1444", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be16fea6bd1042048b8a4008dc005014.json"}}, {"family": "Kopp Kallner", "given": "Helena", "initials": "H", "orcid": "0000-0001-7184-9165", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd943a169d9c47d69749d5831f65a191.json"}}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Eur J Contracept Reprod Health Care", "issn": "1473-0782", "issn-l": null, "volume": "28", "issue": "5", "pages": "275-281"}, "abstract": "Explore perceived access to, the need for, use of, and satisfaction with telemedicine services for contraceptive counselling and prescription-renewal-only during the COVID-19 pandemic, and the impact of the COVID-19 pandemic period on the choice and use of contraceptives.\r\n\r\nInternet-based e-survey of Swedish women of fertile age, 16-49 years.\r\n\r\nIn total, 1016 participants completed the survey. Most participants (69.7%) rated their access to contraceptive services 'as usual'. Among the remaining participants, a higher proportion rated their access as deteriorated (73.4%) compared to improved (26.6%; p < 0.001). In total, 38.0% reported a need for contraceptive counselling, whereof 14.0% had used telemedicine for counselling and reported high satisfaction. Telemedicine for prescription-renewal-only was used by 15.1% of the total population. Two per cent reported use of another contraceptive than their intended, whereof long-acting reversible contraceptives were the most common intended method. The proportion of current contraceptive users was lower than in 2017 (62.4% vs 71.1%, p < 0.001), and current users of long-acting reversible contraception decreased from 30.6% to 19.3% (p < 0.001).\r\n\r\nDuring the COVID-19 pandemic period, most women found their access to contraceptive services unaffected, but more women felt that it had deteriorated than improved. The use of telemedicine was low, and the use of contraception overall fell. Efforts are needed to raise awareness of available services, and TM-provided interventions for maintained quality of care and informed decision-making remain to be evaluated.SHORT CONDENSATIONThe COVID-19 period imposed a change in contraceptive service provision, and efforts are needed to raise awareness of available services, including telemedicine. Access to all contraceptives, including LARCs, is crucial and telemedicine-provided interventions need evaluation.", "doi": "10.1080/13625187.2023.2260516", "pmid": "37902288", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:32:14.142Z", "modified": "2023-11-01T13:56:01.692Z"}, {"entity": "publication", "iuid": "2eab3dd11de845c988ce6eac5a9f9d76", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2eab3dd11de845c988ce6eac5a9f9d76.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2eab3dd11de845c988ce6eac5a9f9d76"}}, "title": "The four domains of the person-centred practice framework from the perspective of critical care nurses in intensive care units during a pandemic.", "authors": [{"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Nordin", "given": "Anna", "initials": "A"}, {"family": "Fredholm", "given": "Angelica", "initials": "A"}, {"family": "Engstr\u00f6m", "given": "\u00c5sa", "initials": "\u00c5"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "issn-l": null, "volume": "78", "issue": null, "pages": "103449"}, "abstract": "The aim was to describe the Person-Centred Practice Framework's four domains (prerequisites, care environment, person-centred processes, and person-centred outcomes) through the perspectives of critical care nurses working in intensive care units during the second year of the COVID-19 pandemic. Furthermore, the aim was to investigate the relationships between prerequisites, care environment, person-centred processes, and person-centred outcomes.\r\n\r\nA cross-sectional study involving questionnaires. Prerequisites were measured using person-related conditions, the care environment by using the Person-Centred Climate Questionnaire-Staff version, the person-centred processes by using the Person-Centred Care Assessment Tool and person-centred outcomes were measured with one question about present health and well-being and by using Self-rated Exhaustion Disorder. Descriptive and analytic statistics were used. Data was collected from July 2021 to November 2021.\r\n\r\nCritical care nurses (n = 217) working in 15 Swedish adult intensive care units.\r\n\r\nParticipants' average length of experience in intensive care units was 14 years, and most participants experienced increased nursing care responsibilities. They perceived the climate as safe but had limitations in terms of its everydayness and community. Participants perceived the organisations both supported and hindered personalized care. Most participants experienced a variety of exhaustion symptoms, and their health had positive relationship with community.\r\n\r\nBy showing how prerequisites, care environment, person-centred process influences critical care nurses' health and well-being, organisations might identify aspects in the work environment that require targeted interventions to reach healthy workplaces.\r\n\r\nTo preserve the health and well-being of critical care nurses and to flourish as humans in their professional roles, they need to interact with and form relationships with their colleagues, patients, and relatives. Organisations should have a person-centred approach for every individual in the workforce to harness each critical care nurses' knowledge and skills for individuals to growth in their roles.", "doi": "10.1016/j.iccn.2023.103449", "pmid": "37169630", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(23)00066-6"}], "notes": [], "created": "2023-10-04T05:12:14.095Z", "modified": "2023-10-04T08:13:38.344Z"}, {"entity": "publication", "iuid": "28090ad69226499a866997ce4999b25f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/28090ad69226499a866997ce4999b25f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/28090ad69226499a866997ce4999b25f"}}, "title": "Social determinants of health and vaccine uptake during the first wave of the COVID-19 pandemic: A systematic review.", "authors": [{"family": "Vardavas", "given": "Constantine", "initials": "C"}, {"family": "Nikitara", "given": "Katerina", "initials": "K"}, {"family": "Aslanoglou", "given": "Katerina", "initials": "K"}, {"family": "Lagou", "given": "Ioanna", "initials": "I"}, {"family": "Marou", "given": "Valia", "initials": "V"}, {"family": "Phalkey", "given": "Revati", "initials": "R"}, {"family": "Leonardi-Bee", "given": "Jo", "initials": "J"}, {"family": "Fernandez", "given": "Esteve", "initials": "E"}, {"family": "Vivilaki", "given": "Victoria", "initials": "V"}, {"family": "Kamekis", "given": "Apostolos", "initials": "A"}, {"family": "Symvoulakis", "given": "Emmanouil", "initials": "E"}, {"family": "Noori", "given": "Teymur", "initials": "T"}, {"family": "Wuerz", "given": "Andrea", "initials": "A"}, {"family": "Suk", "given": "Jonathan E", "initials": "JE"}, {"family": "Deogan", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Prev Med Rep", "issn": "2211-3355", "issn-l": null, "volume": "35", "issue": null, "pages": "102319"}, "abstract": "Social determinants of health significantly impact population health status. The aim of this systematic review was to examine which social vulnerability factors or determinants of health at the individual or county level affected vaccine uptake within the first phase of the vaccination program. We performed a systematic review of peer-reviewed literature published from January 2020 until September 2021 in Medline and Embase (Bagaria et al., 2022) and complemented the review with an assessment of pre-print literature within the same period. We restricted our criteria to studies performed in the EU/UK/EEA/US that report vaccine uptake in the general population as the primary outcome and included various social determinants of health as explanatory variables. This review provides evidence of significant associations between the early phases of vaccination uptake for SARS-CoV-2 and multiple socioeconomic factors including income, poverty, deprivation, race/ethnicity, education and health insurance. The identified associations should be taken into account to increase vaccine uptake in socially vulnerable groups, and to reduce disparities in uptake, in particular within the context of public health preparedness for future pandemics. While further corroboration is needed to explore the generalizability of these findings across the European setting, these results confirm the need to consider vulnerable groups and social determinants of health in the planning and roll-out of SARS-CoV-2 vaccination programs and within the context of future respiratory pandemics.", "doi": "10.1016/j.pmedr.2023.102319", "pmid": "37564118", "labels": {"Category: Public Health": null, "Type: Other": null, "Category: Vaccines": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10410576"}, {"db": "pii", "key": "S2211-3355(23)00210-3"}], "notes": [], "created": "2023-10-05T08:26:56.988Z", "modified": "2023-10-06T05:18:43.511Z"}, {"entity": "publication", "iuid": "f9262871622b4418a92b7fe26ba35003", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f9262871622b4418a92b7fe26ba35003.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f9262871622b4418a92b7fe26ba35003"}}, "title": "Similarities and differences between myocarditis following COVID-19 mRNA vaccine and multiple inflammatory syndrome with cardiac involvement in children.", "authors": [{"family": "Amodio", "given": "Donato", "initials": "D"}, {"family": "Pascucci", "given": "Giuseppe Rubens", "initials": "GR"}, {"family": "Cotugno", "given": "Nicola", "initials": "N"}, {"family": "Rossetti", "given": "Chiara", "initials": "C"}, {"family": "Manno", "given": "Emma Concetta", "initials": "EC"}, {"family": "Pighi", "given": "Chiara", "initials": "C"}, {"family": "Morrocchi", "given": "Elena", "initials": "E"}, {"family": "D'Alessandro", "given": "Annamaria", "initials": "A"}, {"family": "Perrone", "given": "Marco Alfonso", "initials": "MA"}, {"family": "Valentini", "given": "Alessandra", "initials": "A"}, {"family": "Franceschini", "given": "Alessio", "initials": "A"}, {"family": "Chinali", "given": "Marcello", "initials": "M"}, {"family": "Deodati", "given": "Annalisa", "initials": "A"}, {"family": "Azzari", "given": "Chiara", "initials": "C"}, {"family": "Rossi", "given": "Paolo", "initials": "P"}, {"family": "Cianfarani", "given": "Stefano", "initials": "S"}, {"family": "Andreani", "given": "Marco", "initials": "M"}, {"family": "Porzio", "given": "Ottavia", "initials": "O"}, {"family": "Palma", "given": "Paolo", "initials": "P"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Clin Immunol", "issn": "1521-7035", "issn-l": "1521-6616", "volume": "255", "issue": null, "pages": "109751"}, "abstract": "Despite the multiple benefits of vaccination, cardiac adverse Events Following COVID-19 Immunization (c-AEFI) have been reported. These events as well as the severe cardiac involvement reported in Multisystem inflammatory syndrome in children (MIS-C) appear more frequent in young adult males. Herein, we firstly report on the inflammatory profiles of patients experiencing c-AEFI in comparison with age, pubertal age and gender matched MIS-C with cardiac involvement. Proteins related to systemic inflammation were found higher in MIS-C compared to c-AEFI, whereas a higher level in proteins related to myocardial injury was found in c-AEFI. In addition, higher levels of DHEAS, DHEA, and cortisone were found in c-AEFI which persisted at follow-up. No anti-heart muscle and anti-endothelial cell antibodies have been detected. Overall current comparative data showed a distinct inflammatory and androgens profile in c-AEFI patients which results to be well restricted on heart and to persist months after the acute event.", "doi": "10.1016/j.clim.2023.109751", "pmid": "37660743", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S1521-6616(23)00514-4"}], "notes": [], "created": "2023-10-06T06:57:25.920Z", "modified": "2023-10-06T11:44:34.935Z"}, {"entity": "publication", "iuid": "ef42a285208240baa62ce1067842698e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef42a285208240baa62ce1067842698e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef42a285208240baa62ce1067842698e"}}, "title": "SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC).", "authors": [{"family": "Proal", "given": "Amy D", "initials": "AD", "orcid": "0009-0001-9495-8572", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/71ae496981a84b65afae37e357cf914e.json"}}, {"family": "VanElzakker", "given": "Michael B", "initials": "MB"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Bach", "given": "Katie", "initials": "K"}, {"family": "Boribong", "given": "Brittany P", "initials": "BP", "orcid": "0000-0003-1297-6337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb77f79511294f40aca32d51eaf41722.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}, {"family": "Cherry", "given": "Sara", "initials": "S", "orcid": "0000-0003-3956-6610", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ad4bd94f6194d34b799713f6dd29894.json"}}, {"family": "Chertow", "given": "Daniel S", "initials": "DS", "orcid": "0000-0002-1675-1728", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73aa9c5fa5cc484ebb2015a232494c10.json"}}, {"family": "Davies", "given": "Helen E", "initials": "HE", "orcid": "0000-0001-6102-256X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f50576440954cbe858c48cedc8b5965.json"}}, {"family": "Dupont", "given": "Christopher L", "initials": "CL", "orcid": "0000-0002-0896-6542", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7046b17752c5423a9440ad095e12b07a.json"}}, {"family": "Deeks", "given": "Steven G", "initials": "SG"}, {"family": "Eimer", "given": "William", "initials": "W"}, {"family": "Ely", "given": "E Wesley", "initials": "EW"}, {"family": "Fasano", "given": "Alessio", "initials": "A"}, {"family": "Freire", "given": "Marcelo", "initials": "M", "orcid": "0000-0003-4906-7698", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/716676d7968943dab31508c7bd750590.json"}}, {"family": "Geng", "given": "Linda N", "initials": "LN"}, {"family": "Griffin", "given": "Diane E", "initials": "DE"}, {"family": "Henrich", "given": "Timothy J", "initials": "TJ"}, {"family": "Iwasaki", "given": "Akiko", "initials": "A", "orcid": "0000-0002-7824-9856", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1322301ffd9b4e9bb73ade8fd48d3fd3.json"}}, {"family": "Izquierdo-Garcia", "given": "David", "initials": "D"}, {"family": "Locci", "given": "Michela", "initials": "M"}, {"family": "Mehandru", "given": "Saurabh", "initials": "S", "orcid": "0000-0001-9781-2969", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b81ff206ff0442438dc34abdb197326a.json"}}, {"family": "Painter", "given": "Mark M", "initials": "MM", "orcid": "0000-0002-0180-2748", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ec1e890408445f78038bde6f415ae9a.json"}}, {"family": "Peluso", "given": "Michael J", "initials": "MJ"}, {"family": "Pretorius", "given": "Etheresia", "initials": "E"}, {"family": "Price", "given": "David A", "initials": "DA", "orcid": "0000-0001-9416-2737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/734b7fd55fca47f8b00d1281331ef39a.json"}}, {"family": "Putrino", "given": "David", "initials": "D"}, {"family": "Scheuermann", "given": "Richard H", "initials": "RH", "orcid": "0000-0003-1355-892X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e5d8fb69cab46d1a8465f6a9b170d4c.json"}}, {"family": "Tan", "given": "Gene S", "initials": "GS"}, {"family": "Tanzi", "given": "Rudolph E", "initials": "RE", "orcid": "0000-0002-7032-1454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d99336757334246aae0b6ddd36255c2.json"}}, {"family": "VanBrocklin", "given": "Henry F", "initials": "HF"}, {"family": "Yonker", "given": "Lael M", "initials": "LM", "orcid": "0000-0003-1711-8227", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75531a54672a44e7bf7f16d97def6b33.json"}}, {"family": "Wherry", "given": "E John", "initials": "EJ", "orcid": "0000-0003-0477-1956", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8eb744c9e4544fc0b0a7569b48349044.json"}}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Nat Immunol", "issn": "1529-2916", "issn-l": null, "volume": "24", "issue": "10", "pages": "1616-1627"}, "abstract": "Millions of people are suffering from Long COVID or post-acute sequelae of COVID-19 (PASC). Several biological factors have emerged as potential drivers of PASC pathology. Some individuals with PASC may not fully clear the coronavirus SARS-CoV-2 after acute infection. Instead, replicating virus and/or viral RNA-potentially capable of being translated to produce viral proteins-persist in tissue as a 'reservoir'. This reservoir could modulate host immune responses or release viral proteins into the circulation. Here we review studies that have identified SARS-CoV-2 RNA/protein or immune responses indicative of a SARS-CoV-2 reservoir in PASC samples. Mechanisms by which a SARS-CoV-2 reservoir may contribute to PASC pathology, including coagulation, microbiome and neuroimmune abnormalities, are delineated. We identify research priorities to guide the further study of a SARS-CoV-2 reservoir in PASC, with the goal that clinical trials of antivirals or other therapeutics with potential to clear a SARS-CoV-2 reservoir are accelerated.", "doi": "10.1038/s41590-023-01601-2", "pmid": "37667052", "labels": {"Category: Proteins": null, "Category: Post-COVID": null, "Type: Review": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41590-023-01601-2"}], "notes": [], "created": "2023-10-06T06:52:40.952Z", "modified": "2023-10-06T09:52:56.908Z"}, {"entity": "publication", "iuid": "d651eb1d97f847b39b096d2ba9a3e124", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d651eb1d97f847b39b096d2ba9a3e124.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d651eb1d97f847b39b096d2ba9a3e124"}}, "title": "Natural Course of Aortic Stenosis in Older Subjects: Effects of COVID-19.", "authors": [{"family": "Giani", "given": "Anna", "initials": "A"}, {"family": "Xu", "given": "Hong", "initials": "H"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}, {"family": "Fantin", "given": "Francesco", "initials": "F"}, {"family": "Zamboni", "given": "Mauro", "initials": "M"}, {"family": "B\u00e4ck", "given": "Magnus", "initials": "M"}, {"family": "Religa", "given": "Dorota", "initials": "D"}], "type": "observational study", "published": "2023-10-00", "journal": {"title": "J Am Med Dir Assoc", "issn": "1538-9375", "issn-l": null, "volume": "24", "issue": "10", "pages": "1594.e1-1594.e9"}, "abstract": "Both aortic stenosis (AS) and COVID-19 affect the morbidity and mortality burden among older adults. The aim of the study was to examine whether aortic stenosis (AS) affects the prognosis after SARS-CoV-2 infection and whether COVID-19 affects AS prognosis, in a cohort of older adults hospitalized with and without COVID-19.\r\n\r\nObservational study.\r\n\r\nPatients admitted to 9 geriatric clinics in Stockholm from March 2020 to November 2021.\r\n\r\nAS and COVID-19 diagnoses were identified by electronic health records; the outcomes were mortality at 30 days and any time during a median follow-up of 630 days. The associations between AS, COVID-19, and mortality were assessed by using Royston-Parmar models adjusting for age, sex, comorbidities, and admission waves.\r\n\r\nAmong 28,974 patients, 85 had concomitant AS and COVID-19, 529 had only AS, and 5033 had only COVID-19. Both at 30 days and at any time, as compared to patients without, concomitant AS and COVID-19 subjects had a higher mortality rate (438.4 per 100 py, 95% CI 296.2-648.8, and 72.9, 95% CI 53.7-99.0, respectively) and a higher death risk (adjusted HR 5.5, 95% CI 3.7-8.2; and 2.8, 95% CI 2.1-3.9). AS patients presented increased mortality HR both in the presence and absence of COVID-19 at 30 days (1.6, 95% CI 1.1-2.4; and 1.6, 95% CI 1.2-2.2, respectively) and at any time (1.6, 95% CI 1.1-2.1; 1.4, 95% CI 1.2-1.7, respectively).\r\n\r\nAS was a significant mortality risk factor, independent of concomitant COVID-19. Careful AS management should always be pursued, even in acute and post-acute phases of COVID-19.", "doi": "10.1016/j.jamda.2023.07.026", "pmid": "37696497", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1525-8610(23)00715-6"}], "notes": [], "created": "2023-10-06T06:52:25.240Z", "modified": "2023-10-06T09:12:40.597Z"}, {"entity": "publication", "iuid": "de85b64233bf4afc904771cebd31acd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/de85b64233bf4afc904771cebd31acd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/de85b64233bf4afc904771cebd31acd0"}}, "title": "Myoclonus in patients with COVID-19: Findings of autoantibodies against brain structures in cerebrospinal fluid.", "authors": [{"family": "Lindqvist", "given": "Isa", "initials": "I"}, {"family": "Cunningham", "given": "Janet L", "initials": "JL"}, {"family": "Mulder", "given": "Jan", "initials": "J"}, {"family": "Feresiadou", "given": "Amalia", "initials": "A"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Virhammar", "given": "Johan", "initials": "J", "orcid": "0000-0001-9901-2949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9db4ac69a3e8495ea8e71ae60042fa5c.json"}}, {"family": "Kumlien", "given": "Eva", "initials": "E", "orcid": "0000-0002-1952-8791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de1d39588b21438fabae7d27acf4b237.json"}}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Eur J Neurol", "issn": "1468-1331", "issn-l": null, "volume": "30", "issue": "10", "pages": "3142-3148"}, "abstract": "COVID-19 is associated with multiple neurological manifestations. The clinical presentation, trajectory, and treatment response for three cases of myoclonus during COVID-19 infection, with no previous neurological disease, are decsribed.\r\n\r\nAnalysis of cerebrospinal fluid from the cases using indirect immunohistochemistry.\r\n\r\nAntibodies against rodent brain tissue, and similarities in staining patterns were observed, indicating the presence of antineuronal immunoglobulin G autoantibodies targeting astrocytes in the hippocampus.\r\n\r\nOur results demontrate cerebrospinal fluid antineuronal antibodies indicating an an autoimmune involvment in the pathogenesis in COVID-19 associated myoclonus.", "doi": "10.1111/ene.15958", "pmid": "37392418", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:08:31.262Z", "modified": "2023-10-04T12:37:06.510Z"}, {"entity": "publication", "iuid": "d7511b5121ee45ec86cddd07349547ea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d7511b5121ee45ec86cddd07349547ea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d7511b5121ee45ec86cddd07349547ea"}}, "title": "Molnupiravir compared to nirmatrelvir/ritonavir for COVID-19 in high-risk patients with haematological malignancy in Europe. A matched-paired analysis from the EPICOVIDEHA registry.", "authors": [{"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J"}, {"family": "Marchesi", "given": "Francesco", "initials": "F"}, {"family": "Koehler", "given": "Philipp", "initials": "P"}, {"family": "Weinbergerov\u00e1", "given": "Barbora", "initials": "B"}, {"family": "\u010colovi\u0107", "given": "Natasa", "initials": "N"}, {"family": "Falces-Romero", "given": "Iker", "initials": "I"}, {"family": "Buquicchio", "given": "Caterina", "initials": "C"}, {"family": "Farina", "given": "Francesca", "initials": "F"}, {"family": "van Praet", "given": "Jens", "initials": "J"}, {"family": "Biernat", "given": "Monika M", "initials": "MM"}, {"family": "Itri", "given": "Federico", "initials": "F"}, {"family": "Prezioso", "given": "Lucia", "initials": "L"}, {"family": "Tascini", "given": "Carlo", "initials": "C"}, {"family": "Vena", "given": "Antonio", "initials": "A"}, {"family": "Romano", "given": "Alessandra", "initials": "A"}, {"family": "Delia", "given": "Mario", "initials": "M"}, {"family": "D\u00e1vila-Valls", "given": "Julio", "initials": "J"}, {"family": "Mart\u00edn-P\u00e9rez", "given": "Sonia", "initials": "S"}, {"family": "Lavilla-Rubira", "given": "Esperanza", "initials": "E"}, {"family": "Ad\u017ei\u0107-Vuki\u010devi\u0107", "given": "Tatjana", "initials": "T"}, {"family": "Garc\u00eda-Bordallo", "given": "Daniel", "initials": "D"}, {"family": "L\u00f3pez-Garc\u00eda", "given": "Alberto", "initials": "A"}, {"family": "Criscuolo", "given": "Mariana", "initials": "M"}, {"family": "Petzer", "given": "Verena", "initials": "V"}, {"family": "Fracchiolla", "given": "Nicola S", "initials": "NS"}, {"family": "Espigado", "given": "Ildefonso", "initials": "I"}, {"family": "Sili", "given": "Uluhan", "initials": "U"}, {"family": "Meers", "given": "Stef", "initials": "S"}, {"family": "Erben", "given": "Nurettin", "initials": "N"}, {"family": "Cattaneo", "given": "Chiara", "initials": "C"}, {"family": "Tragiannidis", "given": "Athanasios", "initials": "A"}, {"family": "Gavriilaki", "given": "Eleni", "initials": "E"}, {"family": "Sch\u00f6nlein", "given": "Martin", "initials": "M"}, {"family": "Mitrovic", "given": "Mirjana", "initials": "M"}, {"family": "Pantic", "given": "Nikola", "initials": "N"}, {"family": "Merelli", "given": "Maria", "initials": "M"}, {"family": "Labrador", "given": "Jorge", "initials": "J"}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jos\u00e9-\u00c1ngel", "initials": "J"}, {"family": "Glenth\u00f8j", "given": "Andreas", "initials": "A"}, {"family": "Fouquet", "given": "Guillemette", "initials": "G"}, {"family": "Del Principe", "given": "Maria Ilaria", "initials": "MI"}, {"family": "Dargenio", "given": "Michelina", "initials": "M"}, {"family": "Calbacho", "given": "Mar\u00eda", "initials": "M"}, {"family": "Besson", "given": "Caroline", "initials": "C"}, {"family": "Kohn", "given": "Milena", "initials": "M"}, {"family": "Gr\u00e4fe", "given": "Stefanie", "initials": "S"}, {"family": "Hersby", "given": "Ditte Stampe", "initials": "DS"}, {"family": "Arellano", "given": "Elena", "initials": "E"}, {"family": "\u00c7olak", "given": "G\u00f6k\u00e7e Melis", "initials": "GM"}, {"family": "Wolf", "given": "Dominik", "initials": "D"}, {"family": "Marchetti", "given": "Monia", "initials": "M"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Cordoba", "given": "Raul", "initials": "R"}, {"family": "Mi\u0161kovi\u0107", "given": "Bojana", "initials": "B"}, {"family": "Mladenovi\u0107", "given": "Milo\u0161", "initials": "M"}, {"family": "Bavastro", "given": "Martina", "initials": "M"}, {"family": "Limongelli", "given": "Alessandro", "initials": "A"}, {"family": "Rahimli", "given": "Laman", "initials": "L"}, {"family": "Pagano", "given": "Livio", "initials": "L"}, {"family": "Cornely", "given": "Oliver A", "initials": "OA"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Int J Antimicrob Agents", "issn": "1872-7913", "issn-l": null, "volume": "62", "issue": "4", "pages": "106952"}, "abstract": "Molnupiravir and nirmatrelvir/ritonavir are antivirals used to prevent progression to severe SARS-CoV-2 infections and decrease hospitalisation and mortality rates. Nirmatrelvir/ritonavir was authorised in Europe in December 2021, whereas molnupiravir is not yet licensed in Europe as of February 2022. Molnupiravir may be an alternative to nirmatrelvir/ritonavir because it is associated with fewer drug-drug interactions and contraindications. A caveat for molnupiravir is the mode of action induces viral mutations. Mortality rate reduction with molnupiravir was less pronounced than that with nirmatrelvir/ritonavir in patients without haematological malignancy. Little is known about the comparative efficacy of the two drugs in patients with haematological malignancy at high-risk of severe COVID-19. Thus, molnupiravir and nirmatrelvir/ritonavir were compared in a cohort of patients with haematological malignancies.\r\n\r\nClinical data from patients treated with molnupiravir or nirmatrelvir/ritonavir monotherapy for COVID-19 were retrieved from the EPICOVIDEHA registry. Patients treated with molnupiravir were matched by sex, age (\u00b110 years), and severity of baseline haematological malignancy to controls treated with nirmatrelvir/ritonavir.\r\n\r\nA total of 116 patients receiving molnupiravir for the clinical management of COVID-19 were matched to an equal number of controls receiving nirmatrelvir/ritonavir. In each of the groups, 68 (59%) patients were male; with a median age of 64 years (interquartile range [IQR] 53-74) for molnupiravir recipients and 64 years (IQR 54-73) for nirmatrelvir/ritonavir recipients; 56.9% (n=66) of the patients had controlled baseline haematological malignancy, 12.9% (n=15) had stable disease, and 30.2% (n=35) had active disease at COVID-19 onset in each group. During COVID-19 infection, one third of patients from each group were admitted to hospital. Although a similar proportion of patients in the two groups were vaccinated (molnupiravir n=77, 66% vs. nirmatrelvir/ritonavir n=87, 75%), more of those treated with nirmatrelvir/ritonavir had received four vaccine doses (n=27, 23%) compared with those treated with molnupiravir (n=5, 4%) (P<0.001). No differences were detected in COVID-19 severity (P=0.39) or hospitalisation (P=1.0). No statistically significant differences were identified in overall mortality rate (P=0.78) or survival probability (d30 P=0.19, d60 P=0.67, d90 P=0.68, last day of follow up P=0.68). Deaths were either attributed to COVID-19, or the infection was judged by the treating physician to have contributed to death.\r\n\r\nHospitalisation and mortality rates with molnupiravir were comparable to those with nirmatrelvir/ritonavir in high-risk patients with haematological malignancies and COVID-19. Molnupiravir is a plausible alternative to nirmatrelvir/ritonavir for COVID-19 treatment in patients with haematological malignancy.", "doi": "10.1016/j.ijantimicag.2023.106952", "pmid": "37582478", "labels": {"Category: Health": null, "Type: Journal article": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pii", "key": "S0924-8579(23)00231-5"}], "notes": [], "created": "2023-10-05T08:02:33.837Z", "modified": "2023-10-05T08:46:11.473Z"}, {"entity": "publication", "iuid": "25d827196a0f4fc1a51bd72da008cfd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/25d827196a0f4fc1a51bd72da008cfd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/25d827196a0f4fc1a51bd72da008cfd0"}}, "title": "Implementation of a broad public health approach to COVID-19 in Sweden, January 2020 to May 2022.", "authors": [{"family": "Tegnell", "given": "Anders", "initials": "A"}, {"family": "Bess\u00f6", "given": "Anna", "initials": "A"}, {"family": "Bj\u00f6rkholm", "given": "Britta", "initials": "B"}, {"family": "Byfors", "given": "Sara", "initials": "S"}, {"family": "Carlson", "given": "Johan", "initials": "J"}, {"family": "Tegmark Wisell", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "41", "pages": null}, "abstract": "In 2020, the world had to adapt to a pandemic caused by a then novel coronavirus. In addition to its direct impact on morbidity and mortality, the COVID-19 pandemic brought unprecedented control measures and challenges to both individuals and society. Sweden has been seen by many as an outlier in the management of the pandemic. It is therefore of special interest to document the actual management of the pandemic in Sweden during its first 2 years and how public health was affected. In the authors opinion, within the Swedish context, it has been possible to achieve a similar level of effect on mortality and morbidity through recommendations as was achieved through stringent legal measures in comparable countries. This is supported by comparisons of excess mortality that have been published. Furthermore, we see in the available data that the consequences on mental health and living habits were very limited for the majority of the population. Trust in public institutions is high in Sweden, which has been important and is part of the context that made it possible to manage a pandemic with relatively 'soft' measures. We acknowledge challenges in protecting certain vulnerable groups, particularly during the first and second wave.", "doi": "10.2807/1560-7917.ES.2023.28.41.2300063", "pmid": "37824250", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10571492"}], "notes": [], "created": "2023-11-01T13:33:32.026Z", "modified": "2023-11-02T07:23:36.114Z"}, {"entity": "publication", "iuid": "f901d9ad7f8c4b3090a20cf79c347f86", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f901d9ad7f8c4b3090a20cf79c347f86.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f901d9ad7f8c4b3090a20cf79c347f86"}}, "title": "Healthcare workers' experiences of patient safety in the intensive care unit during the COVID-19 pandemic: A multicentre qualitative study.", "authors": [{"family": "Berggren", "given": "Karin", "initials": "K"}, {"family": "Ekstedt", "given": "Mirjam", "initials": "M", "orcid": "0000-0002-4108-391X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd3b314aef4646a5b54fa1132735d1ff.json"}}, {"family": "Joelsson-Alm", "given": "Eva", "initials": "E", "orcid": "0000-0002-9041-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07a091265e654b21bc27fa14b93e4ec0.json"}}, {"family": "Swedberg", "given": "Lena", "initials": "L"}, {"family": "Sackey", "given": "Peter", "initials": "P"}, {"family": "Schandl", "given": "Anna", "initials": "A", "orcid": "0000-0002-3603-1912", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e848555095e546cba3cfcfd8d4609064.json"}}], "type": "multicenter study", "published": "2023-10-00", "journal": {"title": "J Clin Nurs", "issn": "1365-2702", "issn-l": null, "volume": "32", "issue": "19-20", "pages": "7372-7381"}, "abstract": "To describe healthcare workers' experiences of preconditions and patient safety risks in intensive care units during the COVID-19 pandemic.\r\n\r\nHealthcare workers' ability to adapt to changing conditions is crucial to promote patient safety. During the COVID-19 pandemic, healthcare workers' capacity to maintain safe care was challenged and a more in-depth understanding on frontline experiences of patient safety is needed.\r\n\r\nA qualitative descriptive design.\r\n\r\nIndividual interviews were conducted with 29 healthcare workers (nurses, physicians, nurse assistants and physiotherapists) from three Swedish hospitals directly involved in intensive care of COVID-19 patients. Data were analysed with inductive content analysis. Reporting followed the COREQ checklist.\r\n\r\nThree categories were identified. Hazardous changes in working conditions describes patient safety challenges associated with the extreme workload with high stress level. Imperative adaptations induced by changed preconditions for patient safety which include descriptions of safety risks following adaptations related to temporary intensive care facilities, handling shortage of medical equipment and deviations from routines. Safety risks triggered by reorganisation of care describe how the diluted skill-mix and team disruptions exposed patients to safety risks, and that safety performance mostly relied on individual healthcare worker's responsibility.\r\n\r\nThe study suggests that healthcare workers experienced an increase in patient safety risks during the COVID-19 pandemic mainly because the extremely high workload, imperative adaptations, and reorganisation of care regarding skill-mix and teamwork. Patient safety performance relied on the individuals' adaptability and responsibility rather than on system-based safety.\r\n\r\nThis study provides insights on how healthcare workers' experiences can be used as a source of information for recognition of patient safety risks. To improve detection of safety risks during future crises, guidelines on how to approach safety from a system perspective must include healthcare workers' perceptions on safety risks.\r\n\r\nNone in the conceptualisation or design of the study.", "doi": "10.1111/jocn.16793", "pmid": "37291795", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:31:11.760Z", "modified": "2023-10-04T10:45:26.906Z"}, {"entity": "publication", "iuid": "09ec3219c27546cc8c01c94f93fb7933", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/09ec3219c27546cc8c01c94f93fb7933.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/09ec3219c27546cc8c01c94f93fb7933"}}, "title": "GLOBAL RETROSPECTIVE REVIEW OF SEVERE ACUTE RESPIRATORY SYNDROME SARS COV-2 INFECTIONS IN NONDOMESTIC FELIDS: MARCH 2020-FEBRUARY 2021.", "authors": [{"family": "Bartlett", "given": "Susan L", "initials": "SL"}, {"family": "Koeppel", "given": "Katja N", "initials": "KN"}, {"family": "Cushing", "given": "Andrew C", "initials": "AC"}, {"family": "Bellon", "given": "Hugo Fern\u00e1ndez", "initials": "HF"}, {"family": "Almagro", "given": "Vanessa", "initials": "V"}, {"family": "Gyimesi", "given": "Zoltan S", "initials": "ZS"}, {"family": "Thies", "given": "Tammy", "initials": "T"}, {"family": "H\u00e5rd", "given": "Therese", "initials": "T"}, {"family": "Denitton", "given": "Daniel", "initials": "D"}, {"family": "Fox", "given": "Kami Z", "initials": "KZ"}, {"family": "Vodi\u010dka", "given": "Roman", "initials": "R"}, {"family": "Wang", "given": "Leyi", "initials": "L"}, {"family": "Calle", "given": "Paul P", "initials": "PP"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "J Zoo Wildl Med", "issn": "1042-7260", "issn-l": null, "volume": "54", "issue": "3", "pages": "607-616"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in nondomestic felids have been documented in North America, South America, Africa, Europe, and Asia. Between March 2020 and February 2021, at nine institutions across three continents, infection was confirmed in 16 tigers (Panthera tigris), 14 lions (Panthera leo), three snow leopards (Panthera uncia), one cougar (Puma concolor), and one Amur leopard cat (Prionailurus bengalensis euptilurus) ranging from 2 to 21 yr old (average, 10 yr). Infection was suspected in an additional 12 tigers, 4 lions, and 9 cougars. Clinical signs (in order of most to least common) included coughing, ocular and/or nasal discharge, wheezing, sneezing, decreased appetite, lethargy, diarrhea, and vomiting. Most felids recovered uneventfully, but one geriatric tiger with comorbidities developed severe dyspnea and neurologic signs necessitating euthanasia. Clinical signs lasted 1-19 d (average, 8 d); one tiger was asymptomatic. Infection was confirmed by various methods, including antigen tests and/or polymerase chain reaction (PCR) of nasal or oral swabs, tracheal wash, and feces, or virus isolation from feces or tracheal wash. Infection status and resolution were determined by testing nasal swabs from awake animals, fecal PCR, and observation of clinical signs. Shedding of fecal viral RNA was significantly longer than duration of clinical signs. Postinfection seropositivity was confirmed by four institutions including 11 felids (5 lions, 6 tigers). In most instances, asymptomatic or presymptomatic keepers were the presumed or confirmed source of infection, although in some instances the infection source remains uncertain. Almost all infections occurred despite using cloth facemasks and disposable gloves when in proximity to the felids and during food preparation. Although transmission may have occurred during momentary lapses in personal protective equipment compliance, it seems probable that cloth masks are insufficient at preventing transmission of SARS-CoV-2 from humans to nondomestic felids. Surgical or higher grade masks may be warranted when working with nondomestic felids.", "doi": "10.1638/2022-0141", "pmid": "37817628", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:34:22.162Z", "modified": "2023-11-02T07:50:14.136Z"}, {"entity": "publication", "iuid": "b3b031004380472dab4d6dab50438f3a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b3b031004380472dab4d6dab50438f3a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b3b031004380472dab4d6dab50438f3a"}}, "title": "Effect of the SARS-CoV-2 pandemic on planned and emergency hernia repair in Sweden: a register-based study.", "authors": [{"family": "Ali", "given": "Fathalla", "initials": "F", "orcid": "0000-0002-2090-4563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db5cc2ac937040a497cc3ca444a2b84c.json"}}, {"family": "Sandblom", "given": "Gabriel", "initials": "G"}, {"family": "Fathalla", "given": "Blend", "initials": "B"}, {"family": "Wallin", "given": "G\u00f6ran", "initials": "G"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Hernia", "issn": "1248-9204", "issn-l": null, "volume": "27", "issue": "5", "pages": "1103-1108"}, "abstract": "The COVID-19 has had a profound impact on the health care delivery in Sweden, including deprioritization of benign surgeries during the COVID-19 pandemic. The aim of this study was to assess the effect of COVID-19 pandemic on emergency and planned hernia repair in Sweden.\r\n\r\nData on hernia repairs from January 2016 to December 2021 were retrieved from the Swedish Patient Register using procedural codes. Two groups were formed: COVID-19 group (January 2020-December 2021) and control group (January 2016-December 2019). Demographic data on mean age, gender, and type of hernia were collected.\r\n\r\nThis study showed a weak negative correlation between the number of elective hernia repairs performed each month during the pandemic and the number of emergency repairs carried out during the following 3 months for inguinal hernia repair (p = 0.114) and incisional hernia repair (p = 0.193), whereas there was no correlation for femoral or umbilical hernia repairs.\r\n\r\nThe COVID-19 pandemic had a great impact on planned hernia surgeries in Sweden, but our hypothesis that postponing planned repairs would increase the risk of emergency events was not supported.", "doi": "10.1007/s10029-023-02828-6", "pmid": "37418049", "labels": {"Category: Other": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10533583"}, {"db": "pii", "key": "10.1007/s10029-023-02828-6"}], "notes": [], "created": "2023-10-04T12:08:23.566Z", "modified": "2023-10-04T12:34:22.585Z"}, {"entity": "publication", "iuid": "dfed0a9f25d144c7ae8d1907acc1f19f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dfed0a9f25d144c7ae8d1907acc1f19f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dfed0a9f25d144c7ae8d1907acc1f19f"}}, "title": "Catch-up antibody responses and hybrid immunity in mRNA vaccinated patients at risk of severe COVID-19.", "authors": [{"family": "Al-Dury", "given": "Samer", "initials": "S"}, {"family": "Waldenstr\u00f6m", "given": "Jesper", "initials": "J", "orcid": "0000-0003-2234-0076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/191df8f505f044c28ca294008918db62.json"}}, {"family": "Ringlander", "given": "Johan", "initials": "J", "orcid": "0000-0002-8483-6504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64f85af7dceb436498422e62f1a98c89.json"}}, {"family": "Einarsdottir", "given": "Sigrun", "initials": "S", "orcid": "0000-0003-4756-6805", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cfc4ff4119cd4d1abbbce55d38311147.json"}}, {"family": "Andersson", "given": "Markus", "initials": "M"}, {"family": "Hamah Saed", "given": "Hevar", "initials": "H"}, {"family": "Waern", "given": "Johan", "initials": "J"}, {"family": "Martner", "given": "Anna", "initials": "A", "orcid": "0000-0002-6598-5221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c11a2e719c534772a129782bfb60d35c.json"}}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-6617-5976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7bda9f192dc44c587d8a252ef16516b.json"}}, {"family": "Lagging", "given": "Martin", "initials": "M", "orcid": "0000-0002-7995-3626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f059c2a808c46219b90ea780e413ad9.json"}}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": "55", "issue": "10", "pages": "744-750"}, "abstract": "The immunogenicity of repeated vaccination and hybrid immunity in vulnerable patients remains unclear.\r\n\r\nWe studied the impact of iterative Covid-19 mRNA vaccination and hybrid immunity on antibody levels in immunosuppressed subjects. Patients with liver cirrhosis (n = 38), survivors of allogeneic haematopoietic stem cell transplantation (allo-HSCT) (n = 36) and patients with autoimmune liver disease (n = 14) along with healthy controls (n = 20) were monitored for SARS-CoV-2-S1 IgG after their 1st-3rd vaccine doses, 31 of whom became infected with the Omicron variant after the 2nd dose. Ten uninfected allo-HSCT recipients received an additional 4th vaccine dose.\r\n\r\nUnexpectedly, immunosuppressed patients achieved antibody levels in parity with controls after the 3rd vaccine dose. In all study cohorts, hybrid immunity (effect of vaccination and natural infection) resulted in approximately 10-fold higher antibody levels than vaccine-induced immunity alone.\r\n\r\nThree doses of the Covid-19 mRNA vaccine entailed high antibody concentrations even in immunocompromised individuals, and hybrid-immunity resulted further augmented levels than vaccination alone. Clinical trial registration: EudraCT 2021-000349-42.", "doi": "10.1080/23744235.2023.2230289", "pmid": "37395287", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:07:48.708Z", "modified": "2023-10-04T12:26:01.724Z"}, {"entity": "publication", "iuid": "1930eed8da554f868ccdb3405dceb019", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1930eed8da554f868ccdb3405dceb019.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1930eed8da554f868ccdb3405dceb019"}}, "title": "Access to sexual and reproductive health services among South African young people living with and without HIV during the COVID-19 pandemic.", "authors": [{"family": "Giovenco", "given": "Danielle", "initials": "D"}, {"family": "Pettifor", "given": "Audrey", "initials": "A"}, {"family": "Itzikowitz", "given": "Gina", "initials": "G"}, {"family": "Chung", "given": "Stephanie", "initials": "S"}, {"family": "Qayiya", "given": "Yamkela", "initials": "Y"}, {"family": "K\u0227gesten", "given": "Anna E", "initials": "AE"}, {"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM"}, {"family": "Bekker", "given": "Linda-Gail", "initials": "L"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Contraception", "issn": "1879-0518", "issn-l": null, "volume": "126", "issue": null, "pages": "110119"}, "abstract": "To examine sexual and reproductive health (SRH) service access among South African young people during the COVID-19 pandemic.\r\n\r\nWe utilized cross-sectional data collected from February to October 2021 in Cape Town among young people 13-24 years of age living with and without HIV.\r\n\r\nTwo hundred and fifteen young people living with HIV (YPLWH) and 320 young people living without HIV were included. Young people reported an unmet need for SRH services during COVID-19, and 28% of YPLWH reported missing an HIV care appointment during the COVID-19 lockdowns.\r\n\r\nExpanding access to SRH services for young people during disruptive events is critical to reduce disparities in HIV and other SRH outcomes.", "doi": "10.1016/j.contraception.2023.110119", "pmid": "37467919", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0010-7824(23)00209-3"}], "notes": [], "created": "2023-10-04T12:09:17.106Z", "modified": "2023-10-04T12:50:30.860Z"}, {"entity": "publication", "iuid": "14ceb83c4c3844969152393ee4b41045", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/14ceb83c4c3844969152393ee4b41045.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/14ceb83c4c3844969152393ee4b41045"}}, "title": "A meta-meta-analysis of co-infection, secondary infections, and antimicrobial resistance in COVID-19 patients.", "authors": [{"family": "Suleiman", "given": "Adeiza Shuaibu", "initials": "AS"}, {"family": "Islam", "given": "Md Aminul", "initials": "MA"}, {"family": "Akter", "given": "Mir Salma", "initials": "MS"}, {"family": "Amin", "given": "Mohammad Ruhul", "initials": "MR"}, {"family": "Werkneh", "given": "Adhena Ayaliew", "initials": "AA"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}], "type": "systematic review", "published": "2023-10-00", "journal": {"title": "J Infect Public Health", "issn": "1876-035X", "issn-l": null, "volume": "16", "issue": "10", "pages": "1562-1590"}, "abstract": "The newly discovered coronavirus SARS-CoV-2 has sparked a worldwide pandemic of COVID-19, which has caused havoc on medical infrastructures, economies, and cultures around the world. Determining the whole scenario is essential since SARS-CoV-2 variants and sub-variants keep appearing after vaccinations and booster doses. The objective of this secondary meta-analysis is to analysis co-infection, secondary infections, and antimicrobial resistance (AMR) in COVID-19 patients. This study used five significant databases to conduct a systematic review and an overlap meta-analysis to evaluate the pooled estimates of co-infections and secondary infections. The summary of the meta-analysis showed an overall co-infection effect of 26.19% (95% confidence intervals CI: 21.39-31.01, I2 =98.78, n = 14 meta-analysis) among patients with COVID-19. A coinfection effect of 11.13% (95% CI: 9.7-12.56, I2 =99.14, n = 11 meta-analysis) for bacteria; 9.69% (95% CI: 1.21-7.90, I2 =98.33) for fungal and 3.48% (95% CI: 2.15-4.81, I2 =95.84) for viruses. A secondary infection effect of 19.03% (95% CI: 9.53-28.54, I2 =85.65) was pooled from 2 meta-analyses (Ave: 82 primary studies). This is the first study that compiles the results of all the previous three years meta-analyses into a single source and offers strong proof of co-infections and secondary infections in COVID-19 patients. Early detection of co-infection and AMR is crucial for COVID-19 patients in order to effective treatment.", "doi": "10.1016/j.jiph.2023.07.005", "pmid": "37572572", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1876-0341(23)00240-X"}], "notes": [], "created": "2023-10-05T08:01:54.159Z", "modified": "2023-10-05T08:37:48.264Z"}, {"entity": "publication", "iuid": "5d52e0763b144d49bad1aa7e75f1746a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d52e0763b144d49bad1aa7e75f1746a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d52e0763b144d49bad1aa7e75f1746a"}}, "title": "A comparison of COVID-19 incidence rates across six European countries in 2021.", "authors": [{"family": "Padget", "given": "Michael", "initials": "M"}, {"family": "Adam", "given": "Pauline", "initials": "P"}, {"family": "Dorfmuller", "given": "Marina", "initials": "M"}, {"family": "Blondel", "given": "Clara", "initials": "C"}, {"family": "Campos-Matos", "given": "Ines", "initials": "I"}, {"family": "Fayad", "given": "Myriam", "initials": "M"}, {"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Mesher", "given": "David", "initials": "D"}, {"family": "Pistol", "given": "Adriana", "initials": "A"}, {"family": "Rebolledo", "given": "Javiera", "initials": "J"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Riess", "given": "Maximilian", "initials": "M"}, {"family": "Rusu", "given": "Lavinia Cipriana", "initials": "LC"}, {"family": "Che", "given": "Didier", "initials": "D"}, {"family": "Coignard", "given": "Bruno", "initials": "B"}, {"family": "COVID-19 Study group", "given": "", "initials": ""}, {"family": "COVID-19 Study Group members", "given": "", "initials": ""}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "40", "pages": null}, "abstract": "International comparisons of COVID-19 incidence rates have helped gain insights into the characteristics of the disease, benchmark disease impact, shape public health measures and inform potential travel restrictions and border control measures. However, these comparisons may be biased by differences in COVID-19 surveillance systems and approaches to reporting in each country. To better understand these differences and their impact on incidence comparisons, we collected data on surveillance systems from six European countries: Belgium, England, France, Italy, Romania and Sweden. Data collected included: target testing populations, access to testing, case definitions, data entry and management and statistical approaches to incidence calculation. Average testing, incidence and contextual data were also collected. Data represented the surveillance systems as they were in mid-May 2021. Overall, important differences between surveillance systems were detected. Results showed wide variations in testing rates, access to free testing and the types of tests recorded in national databases, which may substantially limit incidence comparability. By systematically including testing information when comparing incidence rates, these comparisons may be greatly improved. New indicators incorporating testing or existing indicators such as death or hospitalisation will be important to improving international comparisons.", "doi": "10.2807/1560-7917.ES.2023.28.40.2300088", "pmid": "37796443", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10557383"}], "notes": [], "created": "2023-11-01T13:33:22.545Z", "modified": "2023-11-02T07:18:16.856Z"}, {"entity": "publication", "iuid": "9c030619934c4fc3ae03dfc8cdbd0329", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9c030619934c4fc3ae03dfc8cdbd0329.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9c030619934c4fc3ae03dfc8cdbd0329"}}, "title": "Immunogenicity and safety of AZD2816, a beta (B.1.351) variant COVID-19 vaccine, and AZD1222 (ChAdOx1 nCoV-19) as third-dose boosters for previously vaccinated adults: a multicentre, randomised, partly double-blinded, phase 2/3 non-inferiority immunobridging study in the UK and Poland.", "authors": [{"family": "Ramasamy", "given": "Maheshi N", "initials": "MN"}, {"family": "Kelly", "given": "Elizabeth J", "initials": "EJ"}, {"family": "Seegobin", "given": "Seth", "initials": "S"}, {"family": "Dargan", "given": "Paul I", "initials": "PI"}, {"family": "Payne", "given": "Ruth", "initials": "R"}, {"family": "Libri", "given": "Vincenzo", "initials": "V"}, {"family": "Adam", "given": "Matthew", "initials": "M"}, {"family": "Aley", "given": "Parvinder K", "initials": "PK"}, {"family": "Martinez-Alier", "given": "Nuria", "initials": "N"}, {"family": "Church", "given": "Alison", "initials": "A"}, {"family": "Jepson", "given": "Brett", "initials": "B"}, {"family": "Khan", "given": "Mark", "initials": "M"}, {"family": "Matthews", "given": "Sam", "initials": "S"}, {"family": "Townsend", "given": "G Todd", "initials": "GT"}, {"family": "Vekemans", "given": "Johan", "initials": "J"}, {"family": "Bibi", "given": "Sagida", "initials": "S"}, {"family": "Swanson", "given": "Phillip A", "initials": "PA"}, {"family": "Lambe", "given": "Teresa", "initials": "T"}, {"family": "Pangalos", "given": "Menelas N", "initials": "MN"}, {"family": "Villafana", "given": "Tonya", "initials": "T"}, {"family": "Pollard", "given": "Andrew J", "initials": "AJ"}, {"family": "Green", "given": "Justin A", "initials": "JA"}, {"family": "AZD2816 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-09-29", "journal": {"title": "The Lancet Microbe", "issn": "2666-5247", "issn-l": "2666-5247", "volume": null, "issue": null, "pages": null}, "abstract": "This study aimed to evaluate AZD2816, a variant-updated COVID-19 vaccine expressing the full-length SARS-CoV-2 beta (B.1.351) variant spike protein that is otherwise similar to AZD1222 (ChAdOx1 nCoV-19), and AZD1222 as third-dose boosters.\r\n\r\nThis phase 2/3, partly double-blinded, randomised, active-controlled study was done at 19 sites in the UK and four in Poland. Adult participants who had received a two-dose AZD1222 or mRNA vaccine primary series were randomly assigned by means of an Interactive Response Technology-Randomisation and Trial Supply Management system (1:1 within each primary-series cohort, stratified by age, sex, and comorbidities) to receive AZD1222 or AZD2816 (intramuscular injection; 5 \u00d7 1010 viral particles). Participants, investigators, and all sponsor staff members involved in study conduct were masked to randomisation. AZD1222 and AZD2816 doses were prepared by unmasked study staff members. The primary objectives were to evaluate safety and humoral immunogenicity (non-inferiority of day-29 pseudovirus neutralising antibody geometric mean titre [GMT] against ancestral SARS-CoV-2: AZD1222 booster vs AZD1222 primary series [historical controls]; margin 0\u00b767; SARS-CoV-2-seronegative participants). This study is registered with ClinicalTrials.gov, NCT04973449, and is completed.\r\n\r\nBetween June 27 and Sept 30, 2021, 1394 participants of the 1741 screened were randomly assigned to AZD1222 or AZD2816 following an AZD1222 (n=373, n=377) or mRNA vaccine (n=322, n=322) primary series. In SARS-CoV-2-seronegative participants receiving AZD1222 or AZD2816, 78% and 80% (AZD1222 primary series) and 90% and 93%, respectively (mRNA vaccine primary series) reported solicited adverse events to the end of day 8; 2%, 2%, 1%, and 1% had serious adverse events and 12%, 12%, 10%, and 11% had adverse events of special interest, respectively, to the end of day 180. The primary immunogenicity non-inferiority endpoint was met: day-29 neutralising antibody GMT ratios (ancestral SARS-CoV-2) were 1\u00b702 (95% CI 0\u00b790-1\u00b714) and 3\u00b747 (3\u00b709-3\u00b789) with AZD1222 booster versus historical controls (AZD1222 and mRNA vaccine primary series, respectively). Responses against beta were greater with AZD2816 versus AZD1222 (GMT ratios, AZD1222, mRNA vaccine primary series 1\u00b784 [1\u00b763-2\u00b708], 2\u00b722 [1\u00b799-2\u00b747]).\r\n\r\nBoth boosters were well tolerated, with immunogenicity against ancestral SARS-CoV-2 similar to AZD1222 primary-series vaccination. AZD2816 gave greater immune responses against beta versus AZD1222.\r\n\r\nAstraZeneca.", "doi": "10.1016/S2666-5247(23)00177-5", "pmid": "37783221", "labels": {"Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2666-5247(23)00177-5"}, {"db": "ClinicalTrials.gov", "key": "NCT04973449"}], "notes": [], "created": "2023-11-01T13:32:28.537Z", "modified": "2023-11-02T07:07:24.695Z"}, {"entity": "publication", "iuid": "27e0d5700ad1481da547ca6ce00cc480", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27e0d5700ad1481da547ca6ce00cc480.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27e0d5700ad1481da547ca6ce00cc480"}}, "title": "High-Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure due to COVID-19: A Multicenter Phase 2 Trial.", "authors": [{"family": "Di Fenza", "given": "Raffaele", "initials": "R", "orcid": "0000-0002-5675-7139", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bcbe9c9fe5f847fabd8d6e53c1b2ea60.json"}}, {"family": "Shetty", "given": "Naman S", "initials": "NS"}, {"family": "Gianni", "given": "Stefano", "initials": "S", "orcid": "0000-0002-0838-3654", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8a1132dcdb545a295319cb92c8d1557.json"}}, {"family": "Parcha", "given": "Vibhu", "initials": "V"}, {"family": "Giammatteo", "given": "Valentina", "initials": "V"}, {"family": "Safaee Fakhr", "given": "Bijan", "initials": "B"}, {"family": "Tornberg", "given": "Daniel", "initials": "D"}, {"family": "Wall", "given": "Olof", "initials": "O"}, {"family": "Harbut", "given": "Piotr", "initials": "P"}, {"family": "Lai", "given": "Peggy S", "initials": "PS", "orcid": "0000-0001-9501-8606", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b173a83f2ea442788446cd145854b2c.json"}}, {"family": "Li", "given": "Jonathan Z", "initials": "JZ"}, {"family": "Paganoni", "given": "Sabrina", "initials": "S"}, {"family": "Cenci", "given": "Stefano", "initials": "S"}, {"family": "Mueller", "given": "Ariel L", "initials": "AL"}, {"family": "Houle", "given": "Timothy T", "initials": "TT"}, {"family": "Akeju", "given": "Oluwaseun", "initials": "O"}, {"family": "Bittner", "given": "Edward A", "initials": "EA"}, {"family": "Bose", "given": "Somnath", "initials": "S"}, {"family": "Scott", "given": "Louie K", "initials": "LK"}, {"family": "Carroll", "given": "Ryan W", "initials": "RW", "orcid": "0000-0002-7513-7023", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/394cd170a6fc4f418d6849a6e4c694f8.json"}}, {"family": "Ichinose", "given": "Fumito", "initials": "F"}, {"family": "Hedenstierna", "given": "Magnus", "initials": "M"}, {"family": "Arora", "given": "Pankaj", "initials": "P"}, {"family": "Berra", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-2702-2093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b2fe95c4fbc402884a22f1d83931708.json"}}], "type": "journal article", "published": "2023-09-29", "journal": {"title": "Am J Respir Crit Care Med", "issn": "1535-4970", "issn-l": "1073-449X", "volume": null, "issue": null, "pages": null}, "abstract": "The effects of high-dose inhaled nitric oxide on hypoxemia in COVID-19 acute respiratory failure are unknown.\r\n\r\nMechanically ventilated adults with COVID-19 pneumonia were enrolled in a phase II, multicenter, single-blind, randomized, controlled, parallel-arm trial. Participants in the intervention arm received inhaled nitric oxide at 80 parts-per-million (ppm) for 48h, compared with the control group receiving usual care (without placebo). The primary outcome was the change in arterial oxy-genation (PaO2/FiO2) at 48h. The secondary outcomes included: time to reach a PaO2/FiO2>300 mmHg for at least 24h, the proportion of participants with a PaO2/FiO2>300 mmHg at 28 days, and survival at 28- and 90-days.\r\n\r\n193 participants were included in the modified intention-to-treat analysis. The mean change in PaO2/FiO2 ratio at 48h was 28.3 mmHg in the intervention group and -1.4 mmHg in the control group (mean difference: 39.1 mmHg (95%CrI:18.1-60.3). The mean time to reach a PaO2/FiO2>300 mmHg in the interventional group was 8.7 days com-pared to 8.4 days for the control group (mean difference:0.44(95%CrI:-3.63 to 4.53)). At 28 days, the proportion of participants attaining a PaO2/FiO2>300 mmHg was 27.7% in the inhaled nitric oxide group and 17.2% in the controls (RR:2.03(95%CrI:1.11 to 3.86)). Duration of ventilation and mortality at 28 and 90 days did not differ. No serious adverse events were reported.\r\n\r\nThe use of high-dose inhaled nitric oxide resulted in an improvement of PaO2/FiO2 at 48h compared with usual care in adults with acute hypoxemic respiratory failure due to COVID-19. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/). Clinical trial registration available at www.\r\n\r\ngov, ID: NCT04306393.", "doi": "10.1164/rccm.202304-0637OC", "pmid": "37774011", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT04306393"}], "notes": [], "created": "2023-10-06T06:57:10.441Z", "modified": "2023-10-06T11:38:31.714Z"}, {"entity": "publication", "iuid": "032ae9a98555402d8605ba6cadfbad32", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/032ae9a98555402d8605ba6cadfbad32.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/032ae9a98555402d8605ba6cadfbad32"}}, "title": "Comparative study between virus neutralisation testing and other serological methods detecting anti-SARS-CoV-2 antibodies in Europe, 2021.", "authors": [{"family": "M\u00f6gling", "given": "Ramona", "initials": "R"}, {"family": "Reimerink", "given": "Johan", "initials": "J"}, {"family": "Stanoeva", "given": "Kamelia R", "initials": "KR"}, {"family": "Keramarou", "given": "Maria", "initials": "M"}, {"family": "Guiomar", "given": "Raquel", "initials": "R"}, {"family": "Costa", "given": "In\u00eas", "initials": "I"}, {"family": "Haveri", "given": "Anu", "initials": "A"}, {"family": "Holzer", "given": "Barbara", "initials": "B"}, {"family": "Korukluo\u011flu", "given": "G\u00fclay", "initials": "G"}, {"family": "Nguyen", "given": "Trung", "initials": "T"}, {"family": "Pakarna", "given": "Gatis", "initials": "G"}, {"family": "Pancer", "given": "Katarzyna", "initials": "K"}, {"family": "Trilar", "given": "Katarina Prosenc", "initials": "KP"}, {"family": "Protic", "given": "Jelena", "initials": "J"}, {"family": "Stojanovi\u0107", "given": "Marijana", "initials": "M"}, {"family": "De Santis", "given": "Riccardo", "initials": "R"}, {"family": "Lista", "given": "Florigio", "initials": "F"}, {"family": "Vremera", "given": "Teodora", "initials": "T"}, {"family": "Leustean", "given": "Mihaela", "initials": "M"}, {"family": "Pistol", "given": "Adriana", "initials": "A"}, {"family": "Zelena", "given": "Hana", "initials": "H"}, {"family": "Reusken", "given": "Chantal", "initials": "C"}, {"family": "Broberg", "given": "Eeva K", "initials": "EK"}], "type": "journal article", "published": "2023-09-29", "journal": {"title": "J Virol Methods", "issn": "1879-0984", "issn-l": null, "volume": "322", "issue": null, "pages": "114825"}, "abstract": "One consequence of the ongoing coronavirus disease pandemic was the rapid development of both in-house and commercial serological assays detecting anti-SARS-CoV-2 antibodies, in an effort to reliably detect acute and past SARS-CoV-2 infections. It is crucial to evaluate the quality of these serological tests and consequently the sero-epidemiological studies that are performed with the respective tests. Here, we describe the set-up and results of a comparative study, in which a laboratory contracted by the European Centre for Disease Prevention and Control offered a centralised service to EU/EEA Member and pre-accession Member States to test representative serum specimens with known serological results, with the gold standard technique (virus neutralisation tests) to determine the presence of neutralising antibodies. Laboratories from 12 European countries shared 719 serum specimens with the contractor laboratory. We found that in-house serological tests detecting neutralising antibodies showed the highest percent agreement, both positive and negative, with the virus neutralisation test results. Despite extensive differences in virus neutralisation protocols neutralisation titres showed a strong correlation. From the commercial assays, the best positive percent agreement was found for SARS-CoV-2 IgG (sCOVG) (Siemens - Atellica IM Analyzer). Despite lower positive percent agreement of LIAISON SARS-CoV-2 TrimericS IgG kit (Diasorin Inc.), the obtained results showed relatively good correlation with neutralisation titres. The set-up of this study allowed for high comparability between laboratories and enabled laboratories that do not have the capacity or capability to perform VNTs themselves. Given the variety of in-house protocols detecting SARS-CoV-2 specific neutralising antibodies, including the virus strain, it could be of interest to select reference isolates for SARS-CoV-2 diagnostic to be made available for interested EU Member States and pre-accession countries.", "doi": "10.1016/j.jviromet.2023.114825", "pmid": "37778539", "labels": {"Category: Biochemistry": null, "Category: Serology": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0166-0934(23)00150-7"}], "notes": [], "created": "2023-11-01T13:34:01.625Z", "modified": "2023-11-02T07:39:20.575Z"}, {"entity": "publication", "iuid": "36ec5251e59b4ffbb0ba152f3d9aecb7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/36ec5251e59b4ffbb0ba152f3d9aecb7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/36ec5251e59b4ffbb0ba152f3d9aecb7"}}, "title": "Changes in stroke and TIA admissions during the COVID-19 pandemic: A meta-analysis.", "authors": [{"family": "Gunnarsson", "given": "Karin", "initials": "K"}, {"family": "Tofiq", "given": "Avin", "initials": "A", "orcid": "0000-0003-1712-7510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1460dc1501cf4a599430688991f6139f.json"}}, {"family": "Mathew", "given": "Alen", "initials": "A"}, {"family": "Cao", "given": "Yang", "initials": "Y", "orcid": "0000-0002-3552-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7594ca0fdf2d4f238ca04a788a405cdb.json"}}, {"family": "von Euler", "given": "Mia", "initials": "M"}, {"family": "Str\u00f6m", "given": "Jakob O", "initials": "JO"}], "type": "journal article", "published": "2023-09-29", "journal": {"title": "Eur Stroke J", "issn": "2396-9881", "issn-l": null, "volume": null, "issue": null, "pages": "23969873231204127"}, "abstract": "To perform a meta-analysis on how the admissions of stroke and transient ischemic attack (TIA) changed during the Corona Virus infection-19 (COVID-19) pandemic and evaluate if the effect was depending on stroke severity.\r\n\r\nObservational cohort studies comparing the number of stroke and/or TIA admissions during a period of the pandemic compared to a period before the pandemic were identified in PubMed and Embase. After excluding studies with overlapping populations and studies without satisfactory case ascertainment, data was extracted and meta-analyzed.\r\n\r\nA total of 59 studies were included. During the pandemic, there was a decrease in admissions of ischemic stroke (admission rate ratio (ARR) = 0.77, 95% confidence interval (CI): 0.72, 0.82), intracerebral hemorrhage (ARR = 0.79, 95% CI: 0.70, 0.90) and TIA (ARR = 0.66, 95% CI: 0.58, 0.75). Albeit admission rates of both mild (ARR = 0.61, 95% CI: 0.49, 0.77) and severe (ARR = 0.82, 95% CI = 0.71, 0.95) strokes decreased, milder strokes decreased more (proportion ratio (PR) = 0.76, 95% CI: 0.65, 0.89).\r\n\r\nPotential causes for the admission reduction could be strict prioritizations within the health care, patients' fear of acquiring COVID-19, or decreased access to health care due to lockdowns.\r\n\r\nDuring the COVID-19 pandemic, there was a reduction in admissions of stroke and TIA, possibly caused by reluctance to seek medical care.", "doi": "10.1177/23969873231204127", "pmid": "37776062", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:32:25.891Z", "modified": "2023-11-02T07:06:00.857Z"}, {"entity": "publication", "iuid": "89f03addb5ce4c9e9e0d934e562cefec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/89f03addb5ce4c9e9e0d934e562cefec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/89f03addb5ce4c9e9e0d934e562cefec"}}, "title": "The Impact of the COVID-19 Pandemic on the Psychological Well-Being of Caregivers of People with Dementia or Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.", "authors": [{"family": "Soysal", "given": "Pinar", "initials": "P", "orcid": "0000-0002-6042-1718", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9532f14058b74f4ba9ef9a91363ef928.json"}}, {"family": "Veronese", "given": "Nicola", "initials": "N", "orcid": "0000-0002-9328-289X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a2cc37554334aa09c617b388c653fd6.json"}}, {"family": "Smith", "given": "Lee", "initials": "L", "orcid": "0000-0002-5340-9833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4a80139dc424c4a83615832dfdff7fc.json"}}, {"family": "Chen", "given": "Yaohua", "initials": "Y", "orcid": "0000-0003-1778-1790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b457f904786486499affe9db4fd9610.json"}}, {"family": "Akpinar Soylemez", "given": "Burcu", "initials": "B"}, {"family": "Coin", "given": "Alessandra", "initials": "A"}, {"family": "Religa", "given": "Dorota", "initials": "D", "orcid": "0000-0003-4583-4570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e2c968ecffa4c638126d6d8d4a0dbd9.json"}}, {"family": "V\u00e4lim\u00e4ki", "given": "Tarja", "initials": "T", "orcid": "0000-0001-6178-5671", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1d17a5f5f124cf1b87188ef357e78a9.json"}}, {"family": "Alves", "given": "Mariana", "initials": "M"}, {"family": "Shenkin", "given": "Susan D", "initials": "SD", "orcid": "0000-0001-7375-4776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/939e65f9dcda409796466872995bdbd1.json"}}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "Geriatrics (Basel)", "issn": "2308-3417", "issn-l": null, "volume": "8", "issue": "5", "pages": null}, "abstract": "The aim of this systematic review was to investigate the effects of the COVID-19 lockdown on the psychological well-being of caregivers of people with dementia or mild cognitive impairment (PwD/MCI). Electronic databases were searched from inception to August 2022 for observational studies investigating the COVID-19 lockdown and psychological well-being of caregivers of PwD/MCI. Summary estimates of standardized mean differences (SMD) in psychological well-being scores pre- versus during COVID-19 were calculated using a random-effects model. Fifteen studies including 1702 caregivers (65.7% female, mean age 60.40 \u00b1 12.9 years) with PwD/MCI were evaluated. Five studies found no change in psychological well-being parameters, including depression, anxiety, distress, caregiver burden, and quality of life. Ten studies found a worsening in at least one parameter: depression (six studies, n = 1368; SMD = 0.40; 95%CI: 0.09-0.71; p = 0.01, I2 = 86.8%), anxiety (seven studies, n = 1569; SMD = 1.35; 95%CI: 0.05-2.65; I2 = 99.2%), caregiver distress (six studies, n = 1320, SMD = 3.190; 95%CI: 1.42-4.95; p < 0.0001; I2 = 99.4%), and caregiver burden (four studies, n = 852, SMD = 0.34; 95%CI: 0.13-0.56; p = 0.001; I2 = 54.1%) (p < 0.05). There was an increase in depression, anxiety, caregiver burden, and distress in caregivers of PwD/MCI during the lockdown in the COVID pandemic. This could have longer term consequences, and it is essential that caregivers' psychological well-being is assessed and supported, to benefit both themselves and those for whom they care.", "doi": "10.3390/geriatrics8050097", "pmid": "37887970", "labels": {"Type: Review": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10606547"}, {"db": "pii", "key": "geriatrics8050097"}], "notes": [], "created": "2023-11-02T07:26:36.865Z", "modified": "2023-11-02T07:27:19.520Z"}, {"entity": "publication", "iuid": "2102e5f0fcb94665b9e6809fb4fb6148", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2102e5f0fcb94665b9e6809fb4fb6148.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2102e5f0fcb94665b9e6809fb4fb6148"}}, "title": "Reproducibility in pharmacometrics applied in a phase III trial of BCG-vaccination for COVID-19.", "authors": [{"family": "van Wijk", "given": "Rob C", "initials": "RC", "orcid": "0000-0001-7247-1360", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aac8bd1a2d674d6c891c1a0becf997d8.json"}}, {"family": "Mockeliunas", "given": "Laurynas", "initials": "L"}, {"family": "van den Hoogen", "given": "Gerben", "initials": "G"}, {"family": "Upton", "given": "Caryn M", "initials": "CM", "orcid": "0000-0002-7503-3320", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/518562f81f0340acaeb7f202bb01403a.json"}}, {"family": "Diacon", "given": "Andreas H", "initials": "AH"}, {"family": "Simonsson", "given": "Ulrika S H", "initials": "USH", "orcid": "0000-0002-3424-9686", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf510f552f2846b5bbb7740872a7c24a.json"}}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "16292"}, "abstract": "Large clinical trials often generate complex and large datasets which need to be presented frequently throughout the trial for interim analysis or to inform a data safety monitory board (DSMB). In addition, reliable and traceability are required to ensure reproducibility in pharmacometric data analysis. A reproducible pharmacometric analysis workflow was developed during a large clinical trial involving 1000 participants over one year testing Bacillus Calmette-Gu\u00e9rin (BCG) (re)vaccination in coronavirus disease 2019 (COVID-19) morbidity and mortality in frontline health care workers. The workflow was designed to review data iteratively during the trial, compile frequent reports to the DSMB, and prepare for rapid pharmacometric analysis. Clinical trial datasets (n = 41) were transferred iteratively throughout the trial for review. An RMarkdown based pharmacometric processing script was written to automatically generate reports for evaluation by the DSMB. Reports were compiled, reviewed, and sent to the DSMB on average three days after the data cut-off, reflecting the trial progress in real-time. The script was also utilized to prepare for the trial pharmacometric analyses. The same source data was used to create analysis datasets in NONMEM format and to support model script development. The primary endpoint analysis was completed three days after data lock and unblinding, and the secondary endpoint analyses two weeks later. The constructive collaboration between clinical, data management, and pharmacometric teams enabled this efficient, timely, and reproducible pharmacometrics workflow.", "doi": "10.1038/s41598-023-43412-3", "pmid": "37770596", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10539503"}, {"db": "pii", "key": "10.1038/s41598-023-43412-3"}], "notes": [], "created": "2023-10-06T06:57:15.951Z", "modified": "2023-10-06T11:40:12.550Z"}, {"entity": "publication", "iuid": "17149842d47b4a09bb7a58f9d9341fb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/17149842d47b4a09bb7a58f9d9341fb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/17149842d47b4a09bb7a58f9d9341fb1"}}, "title": "Neurofilament light chain on intensive care admission is an independent predictor of mortality in COVID-19: a prospective multicenter study.", "authors": [{"family": "Sievert", "given": "Theodor", "initials": "T", "orcid": "0009-0009-9630-2540", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a8d175437a84f5c863058f2207ca332.json"}}, {"family": "Didriksson", "given": "Ingrid", "initials": "I"}, {"family": "Sp\u00e5ngfors", "given": "Martin", "initials": "M"}, {"family": "Lilja", "given": "Gisela", "initials": "G"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Frigyesi", "given": "Attila", "initials": "A"}, {"family": "Friberg", "given": "Hans", "initials": "H"}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "Intensive Care Med Exp", "issn": "2197-425X", "issn-l": null, "volume": "11", "issue": "1", "pages": "66"}, "abstract": "Neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and total-tau protein (tau) are novel blood biomarkers of neurological injury, and may be used to predict outcomes in critical COVID-19.\r\n\r\nA prospective multicentre cohort study of 117 consecutive and critically ill COVID-19 patients in six intensive care units (ICUs) in southern Sweden between May and November 2020. Serial NfL, GFAP and tau were analysed in relation to mortality, the Glasgow Outcome Scale Extended (GOSE) and the physical (PCS) and mental (MCS) components of health-related quality of life at one year.\r\n\r\nNfL, GFAP and tau on ICU admission predicted one-year mortality with an area under the curve (AUC) of 0.82 (95% confidence interval [CI] 0.74[Formula: see text]0.90), 0.72 (95% CI 0.62[Formula: see text]0.82) and 0.66 (95% CI 0.54[Formula: see text]0.77). NfL on admission was an independent predictor of one-year mortality (p = 0.039). Low NfL and GFAP values were associated with good PCS ([Formula: see text]45) at one year but not with good MCS ([Formula: see text]45) or GOSE ([Formula: see text]5).\r\n\r\nNfL on ICU admission was an independent predictor of mortality. High levels of NfL, GFAP and tau were associated with mortality but not with poor GOSE in survivors at one year. Low levels of NfL and GFAP were associated with improved physical health-related quality of life.", "doi": "10.1186/s40635-023-00547-x", "pmid": "37768470", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null, "Category: Public Health": null, "Funder: H2020": null}, "xrefs": [{"db": "pmc", "key": "PMC10539241"}, {"db": "pii", "key": "10.1186/s40635-023-00547-x"}], "notes": [], "created": "2023-10-06T06:56:44.290Z", "modified": "2023-10-06T11:27:36.202Z"}, {"entity": "publication", "iuid": "49150db4defd486aae6259e7cdee919d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49150db4defd486aae6259e7cdee919d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49150db4defd486aae6259e7cdee919d"}}, "title": "Increased intra-pulmonary shunt and alveolar dead space post COVID-19.", "authors": [{"family": "Farrow", "given": "Catherine E", "initials": "CE"}, {"family": "Robles", "given": "Robert", "initials": "R"}, {"family": "Prisk", "given": "G Kim", "initials": "GK"}, {"family": "Harbut", "given": "Piotr", "initials": "P"}, {"family": "Malhotra", "given": "Atul", "initials": "A"}, {"family": "Amis", "given": "Terence C", "initials": "TC"}, {"family": "Wagner", "given": "Peter D", "initials": "PD"}, {"family": "Kairaitis", "given": "Kristina", "initials": "K"}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "J Appl Physiol (1985)", "issn": "1522-1601", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Increased intrapulmonary shunt(QS/Qt) and alveolar dead space(VD/VT) are present in early recovery from COVID-19. We hypothesized patients recovering from severe-critical acute illness(NIH category 3-5) would have greater and longer-lasting increased QS/Qt and VD/VT than patients with mild-moderate acute illness(NIH 1-2).\r\n\r\n59 unvaccinated patients (33 male, age 52[38-61] years, BMI 28.8[25.3-33.6] kg/m2; median[IQR], 44 previous mild-moderate COVID-19, and 15 severe-critical disease), were studied 15-403 days post-acute SARS-CoV-2 infection. Breathing ambient air, steady-state mean alveolar PCO2 and PO2 were recorded simultaneously with arterial PO2/PCO2 yielding aAPCO2, AaPO2, and from these, QS/Qt%, VD/VT%, and relative alveolar ventilation (40 mmHg/PACO2, VArel) calculated.\r\n\r\nMedian PaCO2 was 39.4[35.6-41.1] mmHg, PaO2 92.3[87.1-98.2mmHg; PACO2 32.8[28.6-35.3] mmHg, PAO2 112.9[109.4-117.0] mmHg, AaPO2 18.8[12.6-26.8] mmHg, aAPCO2 5.9 [4.3-8.0] mmHg, QS/Qt 4.3 [2.1-5.9] % and VD/VT16.6 [12.6-24.4] %. Only 14% of patients had normal QS/Qt and VD/VT;1% increased QS/Qt but normal VD/VT; 49% normal QS/Qt and elevated VD/VT;36% both abnormal QS/Qtand VD/VT. Previous severe-critical COVID-19 predicted increased QS/Qt (2.69 [0.82-4.57]% per category severity [95% CI], p<0.01), but not VD/VT. Increasing age weakly predicted increased VD/VT (1.6 [0.1-3.2]% per decade, p<0.04). Time since infection, BMI and comorbidities were not predictors (all p > 0.11). VArel was increased in most patients.\r\n\r\nIn our population, recovery from COVID-19 was associated with increased QS/Qt in 37% of patients, increased VD/VT in 86%, and increased alveolar ventilation up to ~13 months post infection. NIH severity predicted QS/Qt but not elevated VD/VT. Increased VD/VT suggests pulmonary micro-vascular pathology persists post COVID-19 in most patients.", "doi": "10.1152/japplphysiol.00267.2023", "pmid": "37767555", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:56:06.924Z", "modified": "2023-10-06T11:05:04.600Z"}, {"entity": "publication", "iuid": "8a71d2ffb92044e7b93c1c9be9dd275c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a71d2ffb92044e7b93c1c9be9dd275c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a71d2ffb92044e7b93c1c9be9dd275c"}}, "title": "Impact of COVID-19 in Patients with Heart Failure with Mildly Reduced or Preserved Ejection Fraction Enrolled in the DELIVER Trial.", "authors": [{"family": "Bhatt", "given": "Ankeet S", "initials": "AS"}, {"family": "Kosiborod", "given": "Mikhail N", "initials": "MN"}, {"family": "Claggett", "given": "Brian L", "initials": "BL"}, {"family": "Miao", "given": "Zi Michael", "initials": "ZM"}, {"family": "Vaduganathan", "given": "Muthiah", "initials": "M"}, {"family": "Lam", "given": "Carolyn S P", "initials": "CSP"}, {"family": "Hernandez", "given": "Adrian F", "initials": "AF"}, {"family": "Martinez", "given": "Felipe A", "initials": "FA"}, {"family": "Inzucchi", "given": "Silvio E", "initials": "SE"}, {"family": "Shah", "given": "Sanjiv J", "initials": "SJ"}, {"family": "de Boer", "given": "Rudolf A", "initials": "RA"}, {"family": "Jhund", "given": "Pardeep S", "initials": "PS"}, {"family": "Desai", "given": "Akshay S", "initials": "AS"}, {"family": "Fang", "given": "James C", "initials": "JC"}, {"family": "Han", "given": "Yaling", "initials": "Y"}, {"family": "Comin-Colet", "given": "Josep", "initials": "J"}, {"family": "Dro\u017cd\u017c", "given": "Jaros\u0142aw", "initials": "J"}, {"family": "Vardeny", "given": "Orly", "initials": "O"}, {"family": "Merkely", "given": "Bela", "initials": "B"}, {"family": "Lindholm", "given": "Daniel", "initials": "D"}, {"family": "Peterson", "given": "Magnus", "initials": "M"}, {"family": "Langkilde", "given": "Anna Maria", "initials": "AM"}, {"family": "McMurray", "given": "John J V", "initials": "JJV"}, {"family": "Solomon", "given": "Scott D", "initials": "SD"}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "Eur J Heart Fail", "issn": "1879-0844", "issn-l": "1388-9842", "volume": null, "issue": null, "pages": null}, "abstract": "COVID-19 may affect clinical risk in patients with heart failure. DELIVER began before and was conducted during the COVID-19 pandemic.\r\n\r\nWe evaluated the association between COVID-19 and outcomes among DELIVER participants.\r\n\r\nParticipants with chronic HFmrEF/HFpEF were randomized to dapagliflozin or placebo across 350 sites in 20 countries. COVID-19 was investigator-reported and the contribution of COVID-19 to death was centrally adjudicated. We assessed (1) incidence of COVID-19, (2) event rates before/during the pandemic, and (3) risks of death after diagnosis compared to death in participants without COVID-19. Further, we performed a sensitivity analysis assessing treatment effects censored at pandemic onset.\r\n\r\nOf 6263 participants, 589 (9.4%) developed COVID-19, of whom 307 (52%) required/prolonged hospitalization. 155 deaths (15% of all deaths) were adjudicated as definitely/possibly COVID-19 related. COVID-19 cases and deaths did not differ by randomized assignment. Death-rate in the 12-months following diagnosis was 56.1 (95% CI:48.0 to 65.6) vs. 6.4 (95% CI:6.0-6.8)/100-participant-years among trial participants with versus without COVID-19 (aHR:8.60,95% CI:7.18-10.30). Risk was highest 0-3 months following diagnosis (153.5,95% CI:130.3-180.8) and remained elevated at 3-6 months (12.6,95% CI:6.6-24.3/100-participant-years). After excluding investigator reported fatal COVID-19 events, all-cause death rates in the 12 months following diagnosis among COVID-19 survivors (n = 458) remained higher (aHR: 2.46, 95% CI: 1.83 to 3.33) than all trial participants from randomization, with censoring of participants who developed COVID-19 at the time of diagnosis. Dapagliflozin reduced the CV death/worsening HF events when censoring participants at COVID-19 diagnosis (HR:0.81,95%CI:0.72-0.91) and pandemic onset (HR:0.72,95%CI:0.58-0.89). There were no DKA or major hypoglycemic events within 30-days of COVID-19.\r\n\r\nDELIVER is one of the most extensive experiences with COVID-19 of any cardiovascular trial, with >75% of follow-up time occurring during the pandemic. COVID-19 was common, with >50% of cases leading to hospitalization or death. Treatment benefits of dapagliflozin persisted when censoring at COVID-19 diagnosis and pandemic onset. Patients surviving COVID-19 event had a high early residual risk. This article is protected by copyright. All rights reserved.", "doi": "10.1002/ejhf.3043", "pmid": "37771274", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:55:17.131Z", "modified": "2023-10-06T10:49:36.886Z"}, {"entity": "publication", "iuid": "ffccce5c119444b6a27350ba05693be3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ffccce5c119444b6a27350ba05693be3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ffccce5c119444b6a27350ba05693be3"}}, "title": "Gender differences in patient experience in idiopathic inflammatory myopathies: Sub analysis from the COVAD dataset.", "authors": [{"family": "Yoshida", "given": "Akira", "initials": "A", "orcid": "0000-0003-3590-1637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e26dfbeb7e8486a8492abc2700590df.json"}}, {"family": "Kim", "given": "Minchul", "initials": "M"}, {"family": "Kuwana", "given": "Masataka", "initials": "M"}, {"family": "Ravichandran", "given": "Naveen", "initials": "N"}, {"family": "Makol", "given": "Ashima", "initials": "A"}, {"family": "Sen", "given": "Parikshit", "initials": "P"}, {"family": "Lilleker", "given": "James B", "initials": "JB"}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V"}, {"family": "Kardes", "given": "Sinan", "initials": "S"}, {"family": "Day", "given": "Jessica", "initials": "J"}, {"family": "Milchert", "given": "Marcin", "initials": "M"}, {"family": "Joshi", "given": "Mrudula", "initials": "M"}, {"family": "Gheita", "given": "Tamer", "initials": "T"}, {"family": "Salim", "given": "Babur", "initials": "B"}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T"}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE"}, {"family": "Parodis", "given": "Ioannis", "initials": "I"}, {"family": "Nikiphorou", "given": "Elena", "initials": "E"}, {"family": "Chatterjee", "given": "Tulika", "initials": "T"}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL"}, {"family": "Nune", "given": "Arvind", "initials": "A"}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L"}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA"}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK"}, {"family": "Ziade", "given": "Nelly", "initials": "N"}, {"family": "Knitza", "given": "Johannes", "initials": "J"}, {"family": "Distler", "given": "Oliver", "initials": "O"}, {"family": "Chinoy", "given": "Hector", "initials": "H"}, {"family": "Agarwal", "given": "Vikas", "initials": "V"}, {"family": "Aggarwal", "given": "Rohit", "initials": "R"}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "Mod Rheumatol", "issn": "1439-7609", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "We aimed to investigate gender-based differences in idiopathic inflammatory myopathies (IIMs), with a particular focus on patient-reported outcomes, utilizing data obtained through the international COVID-19 vaccination in autoimmune disease (COVAD) e-survey.\r\n\r\nPatient-reported outcomes including fatigue, pain, and physical function were extracted from the COVAD database and compared between genders, adjusting for demographics and IIM subgroups by multivariable analysis. Inclusion body myositis (IBM) was analysed separately because of substantial differences in outcomes.\r\n\r\n1197 complete responses from patients with IIMs as of 31 August 2021 were analysed. Seventy percent were women. Women were younger (58 [48-68] vs. 69 [58-75] years old, median [IQR], p < 0.001) and more likely to suffer from autoimmune multimorbidity, defined as three or more autoimmune diseases in an individual patient (11.4% vs. 2.8%, p < 0.001). In non-IBM IIMs, fatigue visual analogue scale scores were higher in women (5 [3-7] vs. 4 [2-6], median [IQR], p = 0.004), whereas no significant gender-based differences were noted in IBM. Multivariable analysis in non-IBM IIMs revealed women, residence in high-income countries, overlap myositis, and autoimmune multimorbidity were independently associated with increased fatigue.\r\n\r\nWomen with IIMs suffer from autoimmune multimorbidity and experience increased fatigue compared to men.", "doi": "10.1093/mr/road094", "pmid": "37769200", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "7285588"}], "notes": [], "created": "2023-10-06T06:57:42.055Z", "modified": "2023-10-06T11:47:26.839Z"}, {"entity": "publication", "iuid": "16e8a5f9090f4d7c933c8cfd4386eda0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16e8a5f9090f4d7c933c8cfd4386eda0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16e8a5f9090f4d7c933c8cfd4386eda0"}}, "title": "Evaluation of a human mucosal tissue explant model for SARS-CoV-2 replication.", "authors": [{"family": "Gordhan", "given": "Bhavna Gowan", "initials": "BG"}, {"family": "Herrera", "given": "Carolina", "initials": "C"}, {"family": "Pillay", "given": "Azure-Dee", "initials": "A"}, {"family": "Seiphetlo", "given": "Thabiso", "initials": "T"}, {"family": "Ealand", "given": "Christopher Shawn", "initials": "CS"}, {"family": "Machowski", "given": "Edith", "initials": "E"}, {"family": "Singh", "given": "Natasha", "initials": "N"}, {"family": "Seatholo", "given": "Ntombexolo", "initials": "N"}, {"family": "Otwombe", "given": "Kennedy", "initials": "K"}, {"family": "Lebina", "given": "Limakatso", "initials": "L"}, {"family": "Frise", "given": "Rebecca", "initials": "R"}, {"family": "Scarlatti", "given": "Gabriella", "initials": "G"}, {"family": "Chiodi", "given": "Francesca", "initials": "F"}, {"family": "Martinson", "given": "Neil", "initials": "N"}, {"family": "Fox", "given": "Julie", "initials": "J"}, {"family": "Kana", "given": "Bavesh Davandra", "initials": "BD", "orcid": "0000-0001-9713-3480", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/444ca8b6b7e444f1a55ddab2e87c5f2d.json"}}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "9", "pages": "e0291146"}, "abstract": "With the onset of COVID-19, the development of ex vivo laboratory models became an urgent priority to study host-pathogen interactions in response to the pandemic. In this study, we aimed to establish an ex vivo mucosal tissue explant challenge model for studying SARS-CoV-2 infection and replication. Nasal or oral tissue samples were collected from eligible participants and explants generated from the tissue were infected with various SARS-CoV-2 strains, including IC19 (lineage B.1.13), Beta (lineage B.1.351) and Delta (lineage B.1.617.2). A qRT-PCR assay used to measure viral replication in the tissue explants over a 15-day period, demonstrated no replication for any viral strains tested. Based on this, the ex vivo challenge protocol was modified by reducing the viral infection time and duration of sampling. Despite these changes, viral infectivity of the nasal and oral mucosa was not improved. Since 67% of the enrolled participants were already vaccinated against SARS-CoV-2, it is possible that neutralizing antibodies in explant tissue may have prevented the establishment of infection. However, we were unable to optimize plaque assays aimed at titrating the virus in supernatants from both infected and uninfected tissue, due to limited volume of culture supernatant available at the various collection time points. Currently, the reasons for the inability of these mucosal tissue samples to support replication of SARS-CoV-2 ex vivo remains unclear and requires further investigation.", "doi": "10.1371/journal.pone.0291146", "pmid": "37769001", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Other": null, "Category: Genomics & transcriptomics": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC10538748"}, {"db": "pii", "key": "PONE-D-23-15626"}], "notes": [], "created": "2023-10-06T06:52:46.172Z", "modified": "2023-10-06T12:03:46.988Z"}, {"entity": "publication", "iuid": "beb69223dbf744a6a67c81eddf7d1f94", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/beb69223dbf744a6a67c81eddf7d1f94.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/beb69223dbf744a6a67c81eddf7d1f94"}}, "title": "Endotheliitis and cytokine storm as a mechanism of clot formation in COVID-19 ischemic stroke patients: A histopathologic study of retrieved clots.", "authors": [{"family": "Brinjikji", "given": "Waleed", "initials": "W"}, {"family": "Kallmes", "given": "David F", "initials": "DF", "orcid": "0000-0002-8495-0040", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3afdb017a42249bfb13d88ef55c0b77c.json"}}, {"family": "Virmani", "given": "Renu", "initials": "R"}, {"family": "de Meyer", "given": "Simon F", "initials": "SF"}, {"family": "Yoo", "given": "Albert J", "initials": "AJ"}, {"family": "Humphries", "given": "William", "initials": "W"}, {"family": "Zaidat", "given": "Osama O", "initials": "OO"}, {"family": "Teleb", "given": "Mohamed S", "initials": "MS"}, {"family": "Jones", "given": "Jesse G", "initials": "JG", "orcid": "0000-0002-2682-9736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8b2eb443d9242339db2c60ff1e2ff61.json"}}, {"family": "Siddiqui", "given": "Adnan H", "initials": "AH"}, {"family": "Andersson", "given": "Tommy", "initials": "T"}, {"family": "Nogueira", "given": "Raul G", "initials": "RG"}, {"family": "Gil", "given": "Sara Molina", "initials": "SM"}, {"family": "Douglas", "given": "Andrew", "initials": "A"}, {"family": "Rossi", "given": "Rosanna", "initials": "R", "orcid": "0000-0002-3656-2908", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e94c727f4e504aec82996f36a18c4800.json"}}, {"family": "Rentzos", "given": "Alexander", "initials": "A"}, {"family": "Ceder", "given": "Erik", "initials": "E"}, {"family": "Carlqvist", "given": "Jeanette", "initials": "J"}, {"family": "Dunker", "given": "Dennis", "initials": "D"}, {"family": "Jood", "given": "Katarina", "initials": "K"}, {"family": "Tatlisumak", "given": "Turgut", "initials": "T"}, {"family": "Doyle", "given": "Karen M", "initials": "KM", "orcid": "0000-0001-8984-6296", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a3c861faf81495a97e1e85ea3f8dd88.json"}}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "Interv Neuroradiol", "issn": "2385-2011", "issn-l": null, "volume": null, "issue": null, "pages": "15910199231185804"}, "abstract": "Studies during the COVID-19 pandemic have demonstrated an association between COVID-19 virus infection and the development of acute ischemic stroke, particularly large vessel occlusion (LVO). Studying the characteristics and immunohistochemistry of retrieved stroke emboli during mechanical thrombectomy for LVO may offer insights into the pathogenesis of LVO in COVID-19 patients. We examined retrieved COVID-19 emboli from the STRIP, EXCELLENT, and RESTORE registries and compared their characteristics to a control group.\r\n\r\nWe identified COVID-positive LVO patients from the STRIP, RESTORE, and EXCELLENT studies who underwent mechanical thrombectomy. These patients were matched to a control group controlling for stroke etiology based on Trial of Org 10172 in Acute Stroke Treatment criteria. All clots were stained with Martius Scarlet Blue (MSB) along with immunohistochemistry for interleukin-6 (IL-6), C-reactive protein (CRP), von Willebrand factor (vWF), CD66b, fibrinogen, and citrullinated Histone H3. Clot composition was compared between groups.\r\n\r\nNineteen COVID-19-positive patients and 38 controls were included. COVID-19-positive patients had a significantly higher percentage of CRP and vWF. There was no difference in IL-6, fibrin, CD66b, or citrullinated Histone H3 between groups. Based on MSB staining, there was no statistically significant difference regarding the percentage of red blood cells, white blood cells, fibrin, and platelets.\r\n\r\nOur study found higher concentrations of CRP and vWF in retrieved clots of COVID-19-positive stroke patients compared to COVID-19-negative controls. These findings support the potential role of systemic inflammation as indicated by elevated CRP and endothelial injury as indicated by elevated vWF as precipitating factors in thrombus development in these patients.", "doi": "10.1177/15910199231185804", "pmid": "37769315", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:55:14.627Z", "modified": "2023-10-06T10:48:05.804Z"}, {"entity": "publication", "iuid": "d5d748c6457d43149e8ec2a7fe6063af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5d748c6457d43149e8ec2a7fe6063af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5d748c6457d43149e8ec2a7fe6063af"}}, "title": "Prior physical illness predicts death better than acute physiological derangement on intensive care unit admission in COVID-19: A Swedish registry study.", "authors": [{"family": "Stattin", "given": "Karl", "initials": "K", "orcid": "0000-0003-1537-6740", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/249d788a7d1f4088aca67f8265561b9b.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Kawati", "given": "Rafael", "initials": "R"}], "type": "journal article", "published": "2023-09-27", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "9", "pages": "e0292186"}, "abstract": "COVID-19 is associated with prolonged intensive care unit (ICU) stay and considerable mortality. The onset of persistent critical illness, defined as when prior illness predicts death better than acute physiological derangement, has not been studied in COVID-19. This national cohort study based on the Swedish Intensive Care Registry (SIR) included all patients admitted to a Swedish ICU due to COVID-19 from 6 March 2020 to 9 November 2021. Simplified Acute Physiology Score-3 (SAPS3) Box 1 was used as a measure of prior illness and Box 3 as a measure of acute derangement to evaluate the onset and importance of persistent critical illness in COVID-19. To compare predictive capacity, the area under receiver operating characteristic (AUC) of SAPS3 and its constituent Box 1 and 3 was calculated for 30-day mortality. In 7 969 patients, of which 1 878 (23.6%) died within 30 days of ICU admission, the complete SAPS3 score had acceptable discrimination: AUC 0.75 (95% CI 0.74 to 0.76) but showed under prediction in low-risk patients and over prediction in high-risk patients. SAPS3 Box 1 showed markedly better discrimination than Box 3 (AUC 0.74 vs 0.65, P<0,0001). Using custom logistic models, the difference in predictive performance of prior and acute illness was validated, AUC 0.76 vs AUC 0.69, p<0.0001. Prior physical illness predicts death in COVID-19 better than acute physiological derangement during ICU stay, and the whole SAPS3 score is not significantly better than just prior illness. The results suggests that COVID-19 may exhibit similarities to persistent critical illness immediately from ICU admission, potentially because of long median ICU length-of-stay. Alternatively, the variables in the acute physiological derangement model may not adequately capture the severity of illness in COVID-19.", "doi": "10.1371/journal.pone.0292186", "pmid": "37756328", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Public Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: KAW/SciLifeLab": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC10529545"}, {"db": "pii", "key": "PONE-D-23-04974"}], "notes": [], "created": "2023-10-06T06:52:56.012Z", "modified": "2023-10-06T09:59:42.196Z"}, {"entity": "publication", "iuid": "6c3a64fd6fff4dcaa6aa9206c19e2fba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c3a64fd6fff4dcaa6aa9206c19e2fba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c3a64fd6fff4dcaa6aa9206c19e2fba"}}, "title": "Prevalence of SARS-CoV-2 Omicron Sublineages and Spike Protein Mutations Conferring Resistance against Monoclonal Antibodies in a Swedish Cohort during 2022-2023.", "authors": [{"family": "Haars", "given": "Jonathan", "initials": "J", "orcid": "0009-0003-8735-4097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ac6ff5ce97541b9823d1c9204366e56.json"}}, {"family": "Palanisamy", "given": "Navaneethan", "initials": "N", "orcid": "0000-0003-0369-2316", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e92f0f2edcb4c8eaa66f55c59490717.json"}}, {"family": "Wallin", "given": "Frans", "initials": "F"}, {"family": "M\u00f6lling", "given": "Paula", "initials": "P"}, {"family": "Lindh", "given": "Johan", "initials": "J"}, {"family": "Sundqvist", "given": "Martin", "initials": "M"}, {"family": "Ellstr\u00f6m", "given": "Patrik", "initials": "P"}, {"family": "Kaden", "given": "Ren\u00e9", "initials": "R", "orcid": "0000-0002-2111-9751", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2be6374ef0bf4ba39e5f5dbbb059747f.json"}}, {"family": "Lennerstrand", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2023-09-27", "journal": {"title": "Microorganisms", "issn": "2076-2607", "issn-l": "2076-2607", "volume": "11", "issue": "10", "pages": null}, "abstract": "Monoclonal antibodies (mAbs) are an important treatment option for COVID-19 caused by SARS-CoV-2, especially in immunosuppressed patients. However, this treatment option can become ineffective due to mutations in the SARS-CoV-2 genome, mainly in the receptor binding domain (RBD) of the spike (S) protein. In the present study, 7950 SARS-CoV-2 positive samples from the Uppsala and \u00d6rebro regions of central Sweden, collected between March 2022 and May 2023, were whole-genome sequenced using amplicon-based sequencing methods on Oxford Nanopore GridION, Illumina MiSeq, Illumina HiSeq, or MGI DNBSEQ-G400 instruments. Pango lineages were determined and all single nucleotide polymorphism (SNP) mutations that occurred in these samples were identified. We found that the dominant sublineages changed over time, and mutations conferring resistance to currently available mAbs became common. Notable ones are R346T and K444T mutations in the RBD that confer significant resistance against tixagevimab and cilgavimab mAbs. Further, mutations conferring a high-fold resistance to bebtelovimab, such as the K444T and V445P mutations, were also observed in the samples. This study highlights that resistance mutations have over time rendered currently available mAbs ineffective against SARS-CoV-2 in most patients. Therefore, there is a need for continued surveillance of resistance mutations and the development of new mAbs that target more conserved regions of the RBD.", "doi": "10.3390/microorganisms11102417", "pmid": "37894075", "labels": {"Category: Proteins": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10609123"}, {"db": "pii", "key": "microorganisms11102417"}], "notes": [], "created": "2023-11-01T13:31:56.850Z", "modified": "2023-11-01T13:51:18.963Z"}, {"entity": "publication", "iuid": "53b88ea1a9294cf6940e0dc6bb00c61f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53b88ea1a9294cf6940e0dc6bb00c61f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53b88ea1a9294cf6940e0dc6bb00c61f"}}, "title": "Health Care Personnel's Perspectives on Quality of Palliative Care During the COVID-19 Pandemic - A Cross-Sectional Study.", "authors": [{"family": "Granrud", "given": "Marie Dahlen", "initials": "MD"}, {"family": "Gr\u00f8ndahl", "given": "Vigdis Abrahamsen", "initials": "VA", "orcid": "0000-0002-8296-7682", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c34c6c8599e4466af1a3830060dd660.json"}}, {"family": "Helgesen", "given": "Ann Karin", "initials": "AK", "orcid": "0000-0003-4572-9439", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/673ff54d4a6347dfa0b8bb21481e5a8c.json"}}, {"family": "B\u00e5\u00e5th", "given": "Carina", "initials": "C", "orcid": "0000-0002-9608-336X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05b8f4fac40b4da7a00e69b8451cb25b.json"}}, {"family": "Olsson", "given": "Cecilia", "initials": "C"}, {"family": "Tillfors", "given": "Maria", "initials": "M"}, {"family": "Melin-Johansson", "given": "Christina", "initials": "C"}, {"family": "\u00d6sterlind", "given": "Jane", "initials": "J"}, {"family": "Larsson", "given": "Maria", "initials": "M"}, {"family": "Hov", "given": "Reidun", "initials": "R"}, {"family": "Sandsdalen", "given": "Tuva", "initials": "T", "orcid": "0000-0002-6699-8059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6302338a98b0435b988f28517d845fd5.json"}}], "type": "journal article", "published": "2023-09-27", "journal": {"title": "J Multidiscip Healthc", "issn": "1178-2390", "issn-l": null, "volume": "16", "issue": null, "pages": "2893-2903"}, "abstract": "The provision of high-quality palliative care is challenging, especially during a pandemic like COVID-19. The latter entailed major consequences for health care systems and health care personnel (HCP) in both specialist and community health care services, in Norway and worldwide. The aim of this study was to explore how the HCP perceived the quality of palliative care in nursing homes, medical care units, and intensive care units during the COVID-19 pandemic.\r\n\r\nThis study had a cross-sectional design. A total of 290 HCP from Norway participated in the study (RR = 25.8%) between October and December 2021. The questionnaire comprised items concerning respondents' demographics and quality of care, the latter measured by the short form of the Quality from the Patient's Perspective-Palliative Care instrument, adapted for HCP. The STROBE checklist was used.\r\n\r\nThis study shows that the HCP scored subjective importance as higher in all dimensions, items and single items than their perception of the actual care received. This could indicate a need for improvement in all areas. Information about medication, opportunity to participate in decisions about medical and nursing care and continuity regarding receiving help from the same physician and nurse are examples of areas for improvement.\r\n\r\nStudy results indicate that HCP from nursing homes, medical care units, and intensive care units perceived that quality of palliative care provided was not in line with what they perceived to be important for the patient. This indicate that it was challenging to provide high-quality palliative care during the COVID-19 pandemic.", "doi": "10.2147/JMDH.S419442", "pmid": "37790989", "labels": {"Category: Social Science & Humanities": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10543989"}, {"db": "pii", "key": "419442"}], "notes": [], "created": "2023-11-01T13:33:07.426Z", "modified": "2023-11-02T07:12:31.702Z"}, {"entity": "publication", "iuid": "e318b799f41c458f80c14568469c767f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e318b799f41c458f80c14568469c767f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e318b799f41c458f80c14568469c767f"}}, "title": "Cognitive dysfunction in post-COVID-19 condition: Mechanisms, management, and rehabilitation.", "authors": [{"family": "M\u00f6ller", "given": "Marika", "initials": "M"}, {"family": "Borg", "given": "Kristian", "initials": "K"}, {"family": "Janson", "given": "Christer", "initials": "C"}, {"family": "Lerm", "given": "Maria", "initials": "M"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Niward", "given": "Katarina", "initials": "K"}], "type": "journal article", "published": "2023-09-27", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The long-term effects of COVID-19 on cognitive function have become an area of increasing concern. This paper provides an overview of characteristics, risk factors, possible mechanisms, and management strategies for cognitive dysfunction in post-COVID-19 condition (PCC). Prolonged cognitive dysfunction is one of the most common impairments in PCC, affecting between 17% and 28% of the individuals more than 12 weeks after the infection and persisting in some cases for several years. Cognitive dysfunctions can be manifested as a wide range of symptoms including memory impairment, attention deficit, executive dysfunction, and reduced processing speed. Risk factors for developing PCC, with or without cognitive impairments, include advanced age, preexisting medical conditions, and the severity of acute illness. The underlying mechanisms remain unclear, but proposed contributors include neuroinflammation, hypoxia, vascular damage, and latent virus reactivation not excluding the possibility of direct viral invasion of the central nervous system, illustrating complex viral pathology. As the individual variation of the cognitive impairments is large, a neuropsychological examination and a person-centered multidimensional approach are required. According to the World Health Organization, limited evidence on COVID-19-related cognitive impairments necessitates implementing rehabilitation interventions from established practices of similar conditions. Psychoeducation and compensatory skills training are recommended. Assistive products and environmental modifications adapted to individual needs might be helpful. In specific attention- and working memory dysfunctions, cognitive training-carefully monitored for intensity-might be effective for people who do not suffer from post-exertional malaise. Further research is crucial for evidence-based interventions specific to COVID-19-related cognitive impairments.", "doi": "10.1111/joim.13720", "pmid": "37766515", "labels": {"Category: Rehabilitation": null, "Category: Post-COVID": null, "Type: Review": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:55:23.836Z", "modified": "2023-10-06T10:52:52.998Z"}, {"entity": "publication", "iuid": "e1e6f31128384d6aab68ccc445739304", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e1e6f31128384d6aab68ccc445739304.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e1e6f31128384d6aab68ccc445739304"}}, "title": "SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood.", "authors": [{"family": "Lugar", "given": "Marija", "initials": "M"}, {"family": "Eugster", "given": "Anne", "initials": "A"}, {"family": "Achenbach", "given": "Peter", "initials": "P"}, {"family": "von dem Berge", "given": "Thekla", "initials": "T"}, {"family": "Berner", "given": "Reinhard", "initials": "R"}, {"family": "Besser", "given": "Rachel E J", "initials": "REJ"}, {"family": "Casteels", "given": "Kristina", "initials": "K"}, {"family": "Elding Larsson", "given": "Helena", "initials": "H"}, {"family": "Gemulla", "given": "Gita", "initials": "G"}, {"family": "Kordonouri", "given": "Olga", "initials": "O"}, {"family": "Lindner", "given": "Annett", "initials": "A"}, {"family": "Lundgren", "given": "Markus", "initials": "M"}, {"family": "M\u00fcller", "given": "Denise", "initials": "D"}, {"family": "Oltarzewski", "given": "Mariusz", "initials": "M"}, {"family": "Rochtus", "given": "Anne", "initials": "A"}, {"family": "Scholz", "given": "Marlon", "initials": "M"}, {"family": "Szypowska", "given": "Agnieszka", "initials": "A"}, {"family": "Todd", "given": "John A", "initials": "JA"}, {"family": "Ziegler", "given": "Anette-Gabriele", "initials": "A"}, {"family": "Bonifacio", "given": "Ezio", "initials": "E"}, {"family": "GPPAD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-09-26", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484", "volume": "330", "issue": "12", "pages": "1151-1160"}, "abstract": "The incidence of diabetes in childhood has increased during the COVID-19 pandemic. Elucidating whether SARS-CoV-2 infection is associated with islet autoimmunity, which precedes type 1 diabetes onset, is relevant to disease etiology and future childhood diabetes trends.\r\n\r\nTo determine whether there is a temporal relationship between SARS-CoV-2 infection and the development of islet autoimmunity in early childhood.\r\n\r\nBetween February 2018 and March 2021, the Primary Oral Insulin Trial, a European multicenter study, enrolled 1050 infants (517 girls) aged 4 to 7 months with a more than 10% genetically defined risk of type 1 diabetes. Children were followed up through September 2022.\r\n\r\nSARS-CoV-2 infection identified by SARS-CoV-2 antibody development in follow-up visits conducted at 2- to 6-month intervals until age 2 years from April 2018 through June 2022.\r\n\r\nThe development of multiple (\u22652) islet autoantibodies in follow-up in consecutive samples or single islet antibodies and type 1 diabetes. Antibody incidence rates and risk of developing islet autoantibodies were analyzed.\r\n\r\nConsent was obtained for 885 (441 girls) children who were included in follow-up antibody measurements from age 6 months. SARS-CoV-2 antibodies developed in 170 children at a median age of 18 months (range, 6-25 months). Islet autoantibodies developed in 60 children. Six of these children tested positive for islet autoantibodies at the same time as they tested positive for SARS-CoV-2 antibodies and 6 at the visit after having tested positive for SARS-CoV-2 antibodies. The sex-, age-, and country-adjusted hazard ratio for developing islet autoantibodies when the children tested positive for SARS-CoV-2 antibodies was 3.5 (95% CI, 1.6-7.7; P = .002). The incidence rate of islet autoantibodies was 3.5 (95% CI, 2.2-5.1) per 100 person-years in children without SARS-CoV-2 antibodies and 7.8 (95% CI, 5.3-19.0) per 100 person-years in children with SARS-CoV-2 antibodies (P = .02). Islet autoantibody risk in children with SARS-CoV-2 antibodies was associated with younger age (<18 months) of SARS-CoV-2 antibody development (HR, 5.3; 95% CI, 1.5-18.3; P = .009).\r\n\r\nIn young children with high genetic risk of type 1 diabetes, SARS-CoV-2 infection was temporally associated with the development of islet autoantibodies.", "doi": "10.1001/jama.2023.16348", "pmid": "37682551", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10523173"}, {"db": "pii", "key": "2809621"}], "notes": [], "created": "2023-10-06T06:52:51.234Z", "modified": "2023-10-06T09:57:19.959Z"}, {"entity": "publication", "iuid": "063d887726bc402ea8c328b197fd1246", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/063d887726bc402ea8c328b197fd1246.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/063d887726bc402ea8c328b197fd1246"}}, "title": "Risk factors for ventilator-associated lower respiratory tract infection in COVID-19, a retrospective multicenter cohort study in Sweden.", "authors": [{"family": "Forsberg", "given": "Gustaf", "initials": "G"}, {"family": "Taxbro", "given": "Knut", "initials": "K", "orcid": "0000-0001-8711-9044", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53d41b4a81184f4da24af4065e0371e1.json"}}, {"family": "Elander", "given": "Louise", "initials": "L"}, {"family": "Hanberger", "given": "H\u00e5kan", "initials": "H"}, {"family": "Berg", "given": "S\u00f6ren", "initials": "S"}, {"family": "Idh", "given": "Jonna", "initials": "J"}, {"family": "Berkius", "given": "Johan", "initials": "J"}, {"family": "Ekman", "given": "Andreas", "initials": "A", "orcid": "0000-0001-6939-3365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6d19bd5b69440dcbdb168c292ba435f.json"}}, {"family": "Hammarskj\u00f6ld", "given": "Fredrik", "initials": "F"}, {"family": "Niward", "given": "Katarina", "initials": "K"}, {"family": "Balkhed", "given": "\u00c5se \u00d6stholm", "initials": "\u00c5\u00d6"}], "type": "journal article", "published": "2023-09-26", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": null, "issue": null, "pages": null}, "abstract": "Ventilator-associated lower respiratory tract infections (VA-LRTI) increase morbidity and mortality in intensive care unit (ICU) patients. Higher incidences of VA-LRTI have been reported among COVID-19 patients requiring invasive mechanical ventilation (IMV). The primary objectives of this study were to describe clinical characteristics, incidence, and risk factors comparing patients who developed VA-LRTI to patients who did not, in a cohort of Swedish ICU patients with acute hypoxemic respiratory failure due to COVID-19. Secondary objectives were to decipher changes over the three initial pandemic waves, common microbiology and the effect of VA-LTRI on morbidity and mortality.\r\n\r\nWe conducted a multicenter, retrospective cohort study of all patients admitted to 10 ICUs in southeast Sweden between March 1, 2020 and May 31, 2021 because of acute hypoxemic respiratory failure due to COVID-19 and were mechanically ventilated for at least 48 h. The primary outcome was culture verified VA-LRTI. Patient characteristics, ICU management, clinical course, treatments, microbiological findings, and mortality were registered. Logistic regression analysis was conducted to determine risk factors for first VA-LRTI.\r\n\r\nOf a total of 536 included patients, 153 (28.5%) developed VA-LRTI. Incidence rate of first VA-LRTI was 20.8 per 1000 days of IMV. Comparing patients with VA-LRTI to those without, no differences in mortality, age, sex, or number of comorbidities were found. Patients with VA-LRTI had fewer ventilator-free days, longer ICU stay, were more frequently ventilated in prone position, received corticosteroids more often and were more frequently on antibiotics at intubation. Regression analysis revealed increased adjusted odds-ratio (aOR) for first VA-LRTI in patients treated with corticosteroids (aOR 2.64 [95% confidence interval [CI]] [1.31-5.74]), antibiotics at intubation (aOR 2.01 95% CI [1.14-3.66]), and days of IMV (aOR 1.05 per day of IMV, 95% CI [1.03-1.07]). Few multidrug-resistant pathogens were identified. Incidence of VA-LRTI increased from 14.5 per 1000 days of IMV during the first wave to 24.8 per 1000 days of IMV during the subsequent waves.\r\n\r\nWe report a high incidence of culture-verified VA-LRTI in a cohort of critically ill COVID-19 patients from the first three pandemic waves. VA-LRTI was associated with increased morbidity but not 30-, 60-, or 90-day mortality. Corticosteroid treatment, antibiotics at intubation and time on IMV were associated with increased aOR of first VA-LRTI.", "doi": "10.1111/aas.14338", "pmid": "37751991", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:56:11.830Z", "modified": "2023-10-06T11:13:26.767Z"}, {"entity": "publication", "iuid": "15bb56bcd03e462bb05082b9dfbfffd4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15bb56bcd03e462bb05082b9dfbfffd4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15bb56bcd03e462bb05082b9dfbfffd4"}}, "title": "Outpatient Treatment with AZD7442 (Tixagevimab/Cilgavimab) Prevented COVID-19 Hospitalizations over 6 Months and Reduced Symptom Progression in the TACKLE Randomized Trial.", "authors": [{"family": "Hobbs", "given": "F D Richard", "initials": "FDR"}, {"family": "Montgomery", "given": "Hugh", "initials": "H"}, {"family": "Padilla", "given": "Francisco", "initials": "F"}, {"family": "Sim\u00f3n-Campos", "given": "Jesus Abraham", "initials": "JA"}, {"family": "Kim", "given": "Kenneth", "initials": "K"}, {"family": "Arbetter", "given": "Douglas", "initials": "D"}, {"family": "Padilla", "given": "Kelly W", "initials": "KW"}, {"family": "Reddy", "given": "Venkatesh Pilla", "initials": "VP"}, {"family": "Seegobin", "given": "Seth", "initials": "S"}, {"family": "Streicher", "given": "Katie", "initials": "K"}, {"family": "Templeton", "given": "Alison", "initials": "A"}, {"family": "Viani", "given": "Rolando M", "initials": "RM"}, {"family": "Johnsson", "given": "Eva", "initials": "E"}, {"family": "Koh", "given": "Gavin C K W", "initials": "GCKW"}, {"family": "Esser", "given": "Mark T", "initials": "MT"}], "type": "journal article", "published": "2023-09-26", "journal": {"title": "Infect Dis Ther", "issn": "2193-8229", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "We assessed effects of AZD7442 (tixagevimab/cilgavimab) on deaths from any cause or hospitalizations due to coronavirus disease 2019 (COVID-19) and symptom severity and longer-term safety in the TACKLE adult outpatient treatment study.\r\n\r\nParticipants received 600 mg AZD7442 (n = 452) or placebo (n = 451) \u2264 7 days of COVID-19 symptom onset.\r\n\r\nDeath from any cause or hospitalization for COVID-19 complications or sequelae through day 169 (key secondary endpoint) occurred in 20/399 (5.0%) participants receiving AZD7442 versus 40/407 (9.8%) receiving placebo [relative risk reduction (RRR) 49.1%; 95% confidence interval (CI) 14.5, 69.7; p = 0.009] or 50.7% (95% CI 17.5, 70.5; p = 0.006) after excluding participants unblinded before day 169 for consideration of vaccination). AZD7442 reduced progression of COVID-19 symptoms versus placebo through to day 29 (RRR 12.5%; 95% CI 0.5, 23.0) and improved most symptoms within 1-2 weeks. Over median safety follow-up of 170 days, adverse events occurred in 174 (38.5%) and 196 (43.5%) participants receiving AZD7442 or placebo, respectively. Cardiac serious adverse events occurred in two (0.4%) and three (0.7%) participants receiving AZD7442 or placebo, respectively.\r\n\r\nAZD7442 was well tolerated and reduced hospitalization and mortality through 6 months, and symptom burden through 29 days, in outpatients with mild-to-moderate COVID-19.\r\n\r\nClinicaltrials.gov, NCT04723394. ( https://beta.\r\n\r\ngov/study/NCT04723394 ).", "doi": "10.1007/s40121-023-00861-7", "pmid": "37751015", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40121-023-00861-7"}, {"db": "ClinicalTrials.gov", "key": "NCT04723394"}], "notes": [], "created": "2023-10-06T06:56:24.780Z", "modified": "2023-10-06T11:17:53.372Z"}, {"entity": "publication", "iuid": "d2b12b12e20c4ab0b118cffb5ad29b1a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d2b12b12e20c4ab0b118cffb5ad29b1a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d2b12b12e20c4ab0b118cffb5ad29b1a"}}, "title": "New-Onset Diabetes Mellitus in COVID-19: A Scoping Review.", "authors": [{"family": "Pantea Stoian", "given": "Anca", "initials": "A"}, {"family": "Bica", "given": "Ioana-Cristina", "initials": "I"}, {"family": "Salmen", "given": "Teodor", "initials": "T"}, {"family": "Al Mahmeed", "given": "Wael", "initials": "W"}, {"family": "Al-Rasadi", "given": "Khalid", "initials": "K"}, {"family": "Al-Alawi", "given": "Kamila", "initials": "K"}, {"family": "Banach", "given": "Maciej", "initials": "M"}, {"family": "Banerjee", "given": "Yajnavalka", "initials": "Y"}, {"family": "Ceriello", "given": "Antonio", "initials": "A"}, {"family": "Cesur", "given": "Mustafa", "initials": "M"}, {"family": "Cosentino", "given": "Francesco", "initials": "F"}, {"family": "Firenze", "given": "Alberto", "initials": "A"}, {"family": "Galia", "given": "Massimo", "initials": "M"}, {"family": "Goh", "given": "Su-Yen", "initials": "S"}, {"family": "Janez", "given": "Andrej", "initials": "A"}, {"family": "Kalra", "given": "Sanjay", "initials": "S"}, {"family": "Kapoor", "given": "Nitin", "initials": "N"}, {"family": "Kempler", "given": "Peter", "initials": "P"}, {"family": "Lessan", "given": "Nader", "initials": "N"}, {"family": "Lotufo", "given": "Paulo", "initials": "P"}, {"family": "Mikhaildiis", "given": "Dimitri P", "initials": "DP"}, {"family": "Nibali", "given": "Luigi", "initials": "L"}, {"family": "Papanas", "given": "Nikolaos", "initials": "N"}, {"family": "Powell-Wiley", "given": "Tiffany", "initials": "T"}, {"family": "Rizvi", "given": "Ali A", "initials": "AA"}, {"family": "Sahebkar", "given": "Amirhossein", "initials": "A"}, {"family": "Santos", "given": "Raul D", "initials": "RD"}, {"family": "Toth", "given": "Peter P", "initials": "PP"}, {"family": "Viswanathan", "given": "Vijay", "initials": "V"}, {"family": "Rizzo", "given": "Manfredi", "initials": "M"}, {"family": "Cardiometabolic Panel of International Experts on Syndemic COVID-19 (CAPISCO)", "given": "", "initials": ""}], "type": "journal article", "published": "2023-09-26", "journal": {"title": "Diabetes Ther", "issn": "1869-6953", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic became superimposed on the pre-existing obesity and diabetes mellitus (DM) pandemics. Since COVID-19 infection alters the metabolic equilibrium, it may induce pathophysiologic mechanisms that potentiate new-onset DM, and we evaluated this issue.\r\n\r\nA systematic review of the literature published from the 1 January 2020 until the 20 July 2023 was performed (PROSPERO registration number CRD42022341638). We included only full-text articles of both human clinical and randomized controlled trials published in English and enrolling adults (age > 18 years old) with ongoing or preceding COVID-19 in whom hyperglycemia was detected. The search was based on the following criteria: \"(new-onset diabetes mellitus OR new-onset DM) AND (COVID-19) AND adults\".\r\n\r\nArticles on MEDLINE (n = 70) and the Web of Science database (n = 16) were included and analyzed by two researchers who selected 20 relevant articles. We found evidence of a bidirectional relationship between COVID-19 and DM.\r\n\r\nThis link operates as a pathophysiological mechanism supported by epidemiological data and also by the clinical and biological findings obtained from the affected individuals. The COVID-19 pandemic raised the incidence of DM through different pathophysiological and psychosocial factors.", "doi": "10.1007/s13300-023-01465-7", "pmid": "37751143", "labels": {"Category: Health": null, "Category: Post-COVID": null, "Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s13300-023-01465-7"}], "notes": [], "created": "2023-10-06T06:56:19.951Z", "modified": "2023-10-06T11:16:20.895Z"}, {"entity": "publication", "iuid": "857986e34e8c45918f8e99832b77fba3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/857986e34e8c45918f8e99832b77fba3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/857986e34e8c45918f8e99832b77fba3"}}, "title": "Effects of remdesivir on SARS-CoV-2 viral dynamics and mortality in viraemic patients hospitalized for COVID-19.", "authors": [{"family": "Hagman", "given": "Karl", "initials": "K", "orcid": "0000-0002-5965-6130", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f57f6a390d6f4000ab75562643872ef7.json"}}, {"family": "Hedenstierna", "given": "Magnus", "initials": "M", "orcid": "0000-0001-8539-9820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/561a8bfc411142ab8dc9c4e1bffa93da.json"}}, {"family": "Widaeus", "given": "Jacob", "initials": "J"}, {"family": "Arvidsson", "given": "Emelie", "initials": "E"}, {"family": "Hammas", "given": "Berit", "initials": "B"}, {"family": "Grillner", "given": "Lena", "initials": "L"}, {"family": "Jakobsson", "given": "Jan", "initials": "J", "orcid": "0000-0002-5829-1803", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/940a993e912e4b6e98b913efe6c0c08d.json"}}, {"family": "Gille-Johnson", "given": "Patrik", "initials": "P"}, {"family": "Ursing", "given": "Johan", "initials": "J", "orcid": "0000-0002-5508-9327", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88f0c4ae034f4078869e7b9e85ff2d4e.json"}}], "type": "journal article", "published": "2023-09-26", "journal": {"title": "J Antimicrob Chemother", "issn": "1460-2091", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Studies on the antiviral effects of remdesivir have shown conflicting results. SARS-CoV-2 viraemia could identify patients in whom antiviral treatment may be particularly beneficial.\r\n\r\nTo investigate antiviral effects and clinical outcomes of remdesivir treatment in viraemic patients.\r\n\r\nViraemic patients hospitalized for COVID-19 with ratio of arterial oxygen partial pressure to fractional inspired oxygen of \u2264300, symptom duration \u226410 days, and estimated glomerular filtration rate \u226530 mL/min were included in a cohort. The rate of serum viral clearance and serum viral load decline, 60 day mortality and in-hospital outcomes were estimated. A subgroup analysis including patients with symptom duration \u22647 days was performed.\r\n\r\nA total of 318 viraemic patients were included. Thirty-three percent (105/318) received remdesivir. The rate of serum viral clearance [subhazard risk ratio (SHR) 1.4 (95% CI 0.9-2.0), P = 0.11] and serum viral load decline (P = 0.11) were not significantly different between remdesivir-treated patients and controls. However, the rate of serum viral clearance was non-significantly higher [SHR 1.6 (95% CI 1.0-2.7), P = 0.051] and the viral load decline was faster (P = 0.03) in remdesivir-treated patients with symptom duration \u22647 days at admission. The 60 day mortality [HR 1.0 (95% CI 0.6-1.8), P = 0.97] and adverse in-hospital outcomes [OR 1.4 (95% CI 0.8-2.4), P = 0.31] were not significantly different between remdesivir-treated patients and controls.\r\n\r\nRemdesivir treatment did not significantly change the duration of SARS-CoV-2 viraemia, decline of serum viral load, 60 day mortality or in-hospital adverse outcomes in patients with \u226410 days of symptoms at admission. Remdesivir appeared to reduce the duration of viraemia in a subgroup of patients with \u22647 days of symptoms at admission.", "doi": "10.1093/jac/dkad295", "pmid": "37757451", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7283037"}], "notes": [], "created": "2023-10-06T06:53:00.945Z", "modified": "2023-10-06T10:44:02.277Z"}, {"entity": "publication", "iuid": "7b077a08a6e844f7990e9a5e1d9f9d1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b077a08a6e844f7990e9a5e1d9f9d1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b077a08a6e844f7990e9a5e1d9f9d1d"}}, "title": "De novo design of anti-variant COVID-19 vaccine.", "authors": [{"family": "Goswami", "given": "Arpita", "initials": "A", "orcid": "0000-0001-5632-1610", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4b47cfbebb0432ab41fd84d5d227da6.json"}}, {"family": "Kumar", "given": "Madan", "initials": "M"}, {"family": "Ullah", "given": "Samee", "initials": "S", "orcid": "0000-0003-1987-3672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eca60a20784249e9a7ac35c2b394c79b.json"}}, {"family": "Gore", "given": "Milind M", "initials": "MM"}], "type": "journal article", "published": "2023-09-26", "journal": {"title": "Biol Methods Protoc", "issn": "2396-8923", "issn-l": null, "volume": "8", "issue": "1", "pages": "bpad021"}, "abstract": "Recent studies highlight the effectiveness of hybrid Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) vaccines combining wild-type nucleocapsid and Spike proteins. We have further enhanced this strategy by incorporating delta and omicron variants' spike protein mutations. Both delta and omicron mark the shifts in viral transmissibility and severity in unvaccinated and vaccinated patients. So their mutations are highly crucial for future viral variants also. Omicron is particularly adept at immune evasion by mutating spike epitopes. The rapid adaptations of Omicron and sub-variants to spike-based vaccines and simultaneous transmissibility underline the urgency for new vaccines in the continuous battle against SARS-CoV-2. Therefore, we have added three persistent T-cell-stimulating nucleocapsid peptides similar to homologous sequences from seasonal Human Coronaviruses (HuCoV) and an envelope peptide that elicits a strong T-cell immune response. These peptides are clustered in the hybrid spike's cytoplasmic region with non-immunogenic linkers, enabling systematic arrangement. AlphaFold (Artificial intelligence-based model building) analysis suggests omitting the transmembrane domain enhances these cytoplasmic epitopes' folding efficiency which can ensure persistent immunity for CD4+ structural epitopes. Further molecular dynamics simulations validate the compact conformation of the modeled structures and a flexible C-terminus region. Overall, the structures show stability and less conformational fluctuation throughout the simulation. Also, the AlphaFold predicted structural epitopes maintained their folds during simulation to ensure the specificity of CD4+ T-cell response after vaccination. Our proposed approach may provide options for incorporating diverse anti-viral T-cell peptides, similar to HuCoV, into linker regions. This versatility can be promising to address outbreaks and challenges posed by various viruses for effective management in this era of innovative vaccines.", "doi": "10.1093/biomethods/bpad021", "pmid": "37854896", "labels": {"Category: Proteins": null, "Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10580973"}, {"db": "pii", "key": "bpad021"}], "notes": [], "created": "2023-11-01T13:34:12.261Z", "modified": "2023-11-02T07:44:07.338Z"}, {"entity": "publication", "iuid": "79fe4e4fd2ff463795217ce03e9c6ffc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79fe4e4fd2ff463795217ce03e9c6ffc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79fe4e4fd2ff463795217ce03e9c6ffc"}}, "title": "Comprehensive proteomics and meta-analysis of COVID-19 host response.", "authors": [{"family": "Baba\u010di\u0107", "given": "Haris", "initials": "H", "orcid": "0000-0003-0813-0005", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd5aeeb249db49e08f44314024fae6ef.json"}}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f2dc27d02294a15a6f691be6aab641f.json"}}, {"family": "Ara\u00fajo", "given": "Jos\u00e9 Eduardo", "initials": "JE"}, {"family": "Mermelekas", "given": "Georgios", "initials": "G"}, {"family": "Sharma", "given": "Nidhi", "initials": "N"}, {"family": "Tynell", "given": "Janne", "initials": "J", "orcid": "0000-0001-6930-5230", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/239eab38958f497f9162b6f37610ab73.json"}}, {"family": "Garc\u00eda", "given": "Marina", "initials": "M", "orcid": "0000-0002-9130-3933", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5b109d7a54e4c05a48e0f21c4432be6.json"}}, {"family": "Varnaite", "given": "Renata", "initials": "R"}, {"family": "Asgeirsson", "given": "Hilmir", "initials": "H", "orcid": "0000-0003-3869-8021", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/870e3520475b41f8a4f39744b1ecb3ea.json"}}, {"family": "Glans", "given": "Hedvig", "initials": "H"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J", "orcid": "0000-0002-8100-9562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4eb7262dfac84b819fe79856e96eaf76.json"}}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Pernemalm", "given": "Maria", "initials": "M", "orcid": "0000-0003-4624-031X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6801d3242ee544a59d77ccd7256a4a30.json"}}], "type": "meta-analysis", "published": "2023-09-22", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "14", "issue": "1", "pages": "5921"}, "abstract": "COVID-19 is characterised by systemic immunological perturbations in the human body, which can lead to multi-organ damage. Many of these processes are considered to be mediated by the blood. Therefore, to better understand the systemic host response to SARS-CoV-2 infection, we performed systematic analyses of the circulating, soluble proteins in the blood through global proteomics by mass-spectrometry (MS) proteomics. Here, we show that a large part of the soluble blood proteome is altered in COVID-19, among them elevated levels of interferon-induced and proteasomal proteins. Some proteins that have alternating levels in human cells after a SARS-CoV-2 infection in vitro and in different organs of COVID-19 patients are deregulated in the blood, suggesting shared infection-related changes.The availability of different public proteomic resources on soluble blood proteome alterations leaves uncertainty about the change of a given protein during COVID-19. Hence, we performed a systematic review and meta-analysis of MS global proteomics studies of soluble blood proteomes, including up to 1706 individuals (1039 COVID-19 patients), to provide concluding estimates for the alteration of 1517 soluble blood proteins in COVID-19. Finally, based on the meta-analysis we developed CoViMAPP, an open-access resource for effect sizes of alterations and diagnostic potential of soluble blood proteins in COVID-19, which is publicly available for the research, clinical, and academic community.", "doi": "10.1038/s41467-023-41159-z", "pmid": "37739942", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Other": null, "Funder: KAW/SciLifeLab": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC10516886"}, {"db": "pii", "key": "10.1038/s41467-023-41159-z"}], "notes": [], "created": "2023-10-06T06:52:08.783Z", "modified": "2023-10-06T08:17:43.169Z"}, {"entity": "publication", "iuid": "6df48cf185f94d4d8d35cfe2c6b33d1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6df48cf185f94d4d8d35cfe2c6b33d1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6df48cf185f94d4d8d35cfe2c6b33d1d"}}, "title": "What Is the Impact of the Novel Coronavirus and the Vaccination on Guillain-Barre Syndrome?", "authors": [{"family": "Chen", "given": "Yinuo", "initials": "Y"}, {"family": "Li", "given": "Kezheng", "initials": "K"}, {"family": "Lv", "given": "Wenjing", "initials": "W"}, {"family": "Xie", "given": "Jiali", "initials": "J"}, {"family": "Qian", "given": "Yuqin", "initials": "Y"}, {"family": "Cui", "given": "Can", "initials": "C"}, {"family": "Deng", "given": "Binbin", "initials": "B", "orcid": "0000-0002-4058-0738", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/592a6c15241f467cb88b21a1853ed8be.json"}}], "type": "journal article", "published": "2023-09-20", "journal": {"title": "Mol Neurobiol", "issn": "1559-1182", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has resulted in devastating medical and economic consequences worldwide over the past 3 years. As the pandemic enters a new stage, it is essential to consider the potential impact on rare diseases such as Guillain-Barre syndrome (GBS), which has been intimately associated with COVID-19 since the first COVID-19-related GBS case was reported in January 2020. There are notable differences between COVID-19-related GBS and GBS without COVID-19 in terms of diagnostic types and clinical manifestations. Furthermore, with the widespread administration of COVID-19 vaccines, there have been reports of GBS occurring shortly after vaccination, which requires close attention despite its rarity. This review also explores the vaccines associated with heightened GBS risks, offering insights that may guide vaccination policies and clinical practice. To provide a visual summary of these findings, we have included a graphical abstract. This article will discuss the characteristic manifestations of GBS patients after being positive for the novel coronavirus and the safety of several COVID-19 vaccines. Firstly, this article comprehensively expounds and discusses the epidemiological aspects of novel coronavirus-related GBS. For example, from the perspective of the same population, the expected incidence of GBS in the COVID-19-positive population (persons/100,000 persons/ year) is about 43 times that of the COVID-19-negative population, and the incidence of GBS is significantly increased. Secondly, the clinical characteristics of COVID-19-negative GBS patients and SARS-CoV-2-GBS (SC2-GBS) patients were summarized and compared. Thirdly, this article reviews GBS cases in the current adverse events after COVID-19 vaccination and analyzes and discusses from multiple perspectives, such as the incidence of GBS events, the age proportion of patients, and the interval of onset.", "doi": "10.1007/s12035-023-03638-8", "pmid": "37728848", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "10.1007/s12035-023-03638-8"}], "notes": [], "created": "2023-10-06T06:52:20.586Z", "modified": "2023-10-06T08:47:40.883Z"}, {"entity": "publication", "iuid": "9fab0e58ed044f48bdcf82502fdbfc0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9fab0e58ed044f48bdcf82502fdbfc0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9fab0e58ed044f48bdcf82502fdbfc0e"}}, "title": "Strict self-isolation did not protect Swedish cancer patients on active treatment from the risk of becoming seropositive for SARS-CoV-2.", "authors": [{"family": "Ginman", "given": "Beatrice", "initials": "B"}, {"family": "Pahnke", "given": "Simon", "initials": "S", "orcid": "0000-0002-3541-2027", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f7056035dab4a0080d35b40977463a8.json"}}, {"family": "Freyhult", "given": "Eva", "initials": "E"}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Kolstad", "given": "Linda", "initials": "L"}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Hamberg Levedahl", "given": "Kerstin", "initials": "K"}, {"family": "Enblad", "given": "Gunilla", "initials": "G"}, {"family": "Glimelius", "given": "Ingrid", "initials": "I", "orcid": "0000-0001-6158-3041", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4407b480fb244249063d1cc74513c67.json"}}], "type": "journal article", "published": "2023-09-20", "journal": {"title": "Acta Oncol", "issn": "1651-226X", "issn-l": null, "volume": null, "issue": null, "pages": "1-9"}, "abstract": "Background: Swedish recommendations to reduce the risk of COVID-19 relied on each citizen's own sense of responsibility rather than mandatory lockdowns. We studied how COVID-19-related self-isolation and anxiety correlated to SARS-CoV-2 seropositivity and PCR-positivity in patients with active cancer treatment.Methods: In a longitudinal cohort study at Uppsala University Hospital patients and cancer personnel were included between April 1st 2020 to August 1st 2020. Serological testing for SARS-CoV-2 was done every 8-12-weeks until 30 March 2021. Patients completed a survey at inclusion regarding self-reported COVID-19-related anxiety and self-isolation.Results: A total of 622 patients [n = 475 with solid malignancies (SM), n = 147 with haematological malignancies (HM)], and 358 healthcare personnel were included. The seropositivity rate was lower for patients than for personnel; 10.5% for SM patients, 6.8% for HM patients, and 16.2% for personnel (p = 0.005). Strict adherence to self-isolation guidelines was reported by 54% of patients but was not associated with a lower risk of becoming seropositive [OR = 1.4 (0.8-2.5), p = 0.2]. High anxiety was expressed by 32% of patients, more often by SM patients than HM patients (34% vs 25% [OR = 1.6 (1.1-2.5, p = 0.03)]). Female gender [OR = 3.5 (2.4-5.2), p < 0.001] and being born outside of Europe [OR = 2.9 (1.4-6.4), p = 0.007] were both associated with high anxiety. Patients reporting high anxiety became seropositive to a similar degree as those with low anxiety [OR = 0.7 (0.3-1.2), p = 0.2]. HM patients with PCR-positive COVID-19 were more likely than SM patients to require oxygen therapy, including non-invasive ventilation/intubation (69% vs. 26%, p = 0.005).Conclusion: For Swedish patients on active cancer treatment, high self-assessed COVID-19-related anxiety or strict adherence to self-isolation guidelines were not associated with a lower risk of COVID-19. Patients with HM were less likely to develop serological antibody response after COVID-19 and were more likely to require advanced hospital care, but expressed less COVID-19-related anxiety than patients with SM.", "doi": "10.1080/0284186X.2023.2257873", "pmid": "37729083", "labels": {"Category: Health": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Social Science & Humanities": null, "Category: Serology": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:52:22.926Z", "modified": "2023-10-06T08:49:11.876Z"}, {"entity": "publication", "iuid": "4260eeddc24f443e8616014380ebb666", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4260eeddc24f443e8616014380ebb666.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4260eeddc24f443e8616014380ebb666"}}, "title": "Predictors of the post-COVID condition following mild SARS-CoV-2 infection.", "authors": [{"family": "Reme", "given": "B-A", "initials": "B"}, {"family": "Gjesvik", "given": "J", "initials": "J"}, {"family": "Magnusson", "given": "K", "initials": "K", "orcid": "0000-0003-4851-5794", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2fe6a28f36f40a998b8c9fc3c5ebe73.json"}}], "type": "journal article", "published": "2023-09-20", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "14", "issue": "1", "pages": "5839"}, "abstract": "Whereas the nature of the post-COVID condition following mild acute COVID-19 is increasingly well described in the literature, knowledge of its risk factors, and whether it can be predicted, remains limited. This study, conducted in Norway, uses individual-level register data from 214,667 SARS-CoV-2 infected individuals covering a range of demographic, socioeconomic factors, as well as cause-specific healthcare utilization in the years prior to infection to assess the risk of post-COVID complaints \u22653 months after testing positive. We find that the risk of post-COVID was higher among individuals who prior to infection had been diagnosed with psychological (OR = 2.12, 95% CI 1.84-2.44), respiratory (OR = 2.03, 95% CI 1.78-2.32), or general and unspecified health problems (OR = 1.78, 95% CI 1.52-2.09). To assess the predictability of post-COVID after mild initial disease, we use machine learning methods and find that pre-infection characteristics, combined with information on the SARS-CoV-2 virus type and vaccine status, to a considerable extent (AUC = 0.79, 95% CI 0.75-0.81) could predict the occurrence of post-COVID complaints in our sample.", "doi": "10.1038/s41467-023-41541-x", "pmid": "37730740", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC10511472"}, {"db": "pii", "key": "10.1038/s41467-023-41541-x"}], "notes": [], "created": "2023-10-06T12:26:24.681Z", "modified": "2023-10-06T12:32:45.559Z"}, {"entity": "publication", "iuid": "07d0b69a0592471ba8f3f12bccd0b798", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07d0b69a0592471ba8f3f12bccd0b798.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07d0b69a0592471ba8f3f12bccd0b798"}}, "title": "Mental health, stress, and well-being measured before (2019) and during (2020) COVID-19: a Swedish socioeconomic population-based study.", "authors": [{"family": "Lindqvist Bagge", "given": "Ann-Sophie", "initials": "A"}, {"family": "Lekander", "given": "Mats", "initials": "M", "orcid": "0000-0003-3998-1494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e04a9b05c67472980549da294267381.json"}}, {"family": "Olofsson Bagge", "given": "Roger", "initials": "R", "orcid": "0000-0001-5795-0355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0502c52a1b65446fa2e4b726906c9d51.json"}}, {"family": "Carlander", "given": "Anders", "initials": "A", "orcid": "0000-0002-4435-7648", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb81228e2951462ab407f261fa9e6d02.json"}}], "type": "journal article", "published": "2023-09-20", "journal": {"title": "Psychol Health", "issn": "1476-8321", "issn-l": null, "volume": null, "issue": null, "pages": "1-18"}, "abstract": "Compare mental health, stress, and well-being in the Swedish population as measured before and during the COVID-19 pandemic.\r\n\r\nRepeated cross-sectional design using data measured before (Jan-2019; n = 2791) and during (Oct/Nov-2020; n = 2926) COVID-19 pandemic in Swedish population-representative cohorts. Following constructs were measured: anxiety (Beck Anxiety Inventory), depression (Beck Depression Inventory-II), stress (Perceived Stress Scale-10 items), health-related quality of life (HRQOL[Functional Assessment of Cancer Therapy-General Population]) and self-rated health (SRH) was assessed with a single-item question.\r\n\r\nWhen adjusting for age, sex, education, and income there were significantly higher levels of anxiety (M\u0302 = 9.15 vs. 8.48, p < 0.01) and depression (M\u0302 = 3.64 vs. 3.30, p = 0.03), lower levels of stress (M\u0302 = 14.06 vs. 14.91, p < 0.001), but worsened HRQOL (M\u0302 = 76.40 vs. 77.92, p < 0.01) and SRH (M\u0302 = 6.91 vs. 7.20, p < 0.001), observed in 2020 compared to 2019. For the negative effects seen in anxiety, depression, HRQOL, and SRH, higher income and education had a protective effect. The decrease in stress was also correlated with higher income.\r\n\r\nThe COVID-19 pandemic led to a small but significant worsening in mental health and well-being in the general Swedish population, where higher socioeconomic status seemed to have a protective effect.", "doi": "10.1080/08870446.2023.2257747", "pmid": "37728316", "labels": {"Type: Journal article": null, "Funder: Forte": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:56:02.078Z", "modified": "2023-10-06T10:58:34.391Z"}, {"entity": "publication", "iuid": "c7faff32e1944754ad92588bd7d575fe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7faff32e1944754ad92588bd7d575fe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7faff32e1944754ad92588bd7d575fe"}}, "title": "Prevalence and impact of chronic dysglycaemia among patients with COVID-19 in Swedish intensive care units: a multicentre, retrospective cohort study.", "authors": [{"family": "Balintescu", "given": "Anca", "initials": "A", "orcid": "0000-0001-8665-5742", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/97e90fbd52e64ac7b6d6dbd91a2db88c.json"}}, {"family": "Rysz", "given": "Susanne", "initials": "S"}, {"family": "Hertz", "given": "Carl", "initials": "C"}, {"family": "Grip", "given": "Jonathan", "initials": "J"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Oldner", "given": "Anders", "initials": "A"}, {"family": "Svensen", "given": "Christer", "initials": "C"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}], "type": "observational study", "published": "2023-09-19", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "9", "pages": "e071330"}, "abstract": "Using glycated haemoglobin A1c (HbA1c) screening, we aimed to determine the prevalence of chronic dysglycaemia among patients with COVID-19 admitted to the intensive care unit (ICU). Additionally, we aimed to explore the association between chronic dysglycaemia and clinical outcomes related to ICU stay.\r\n\r\nMulticentre retrospective observational study.\r\n\r\nICUs in three hospitals in Stockholm, Sweden.\r\n\r\nCOVID-19 patients admitted to the ICU between 5 March 2020 and 13 August 2020 with available HbA1c at admission. Chronic dysglycaemia was determined based on previous diabetes history and HbA1c.\r\n\r\nPrimary outcome was the actual prevalence of chronic dysglycaemia (pre-diabetes, unknown diabetes or known diabetes) among COVID-19 patients. Secondary outcome was the association of chronic dysglycaemia with 90-day mortality, ICU length of stay, duration of invasive mechanical ventilation (IMV) and renal replacement therapy (RRT), accounting for treatment selection bias.\r\n\r\nA total of 308 patients with available admission HbA1c were included. Chronic dysglycaemia prevalence assessment was restricted to 206 patients admitted ICUs in which HbA1c was measured on all admitted patients. Chronic dysglycaemia was present in 82.0% (95% CI 76.1% to 87.0%) of patients, with pre-diabetes present in 40.2% (95% CI 33.5% to 47.3%), unknown diabetes in 20.9% (95% CI 15.5% to 27.1%), well-controlled diabetes in 7.8% (95% CI 4.5% to 12.3%) and uncontrolled diabetes in 13.1% (95% CI 8.8% to 18.5%). All patients with available HbA1c were included for the analysis of the relationship between chronic dysglycaemia and secondary outcomes. We found no independent association between chronic dysglycaemia and 90-day mortality, ICU length of stay or duration of IMV. After excluding patients with specific treatment limitations, no association between chronic dysglycaemia and RRT use was observed.\r\n\r\nIn our cohort of critically ill COVID-19 patients, the prevalence of chronic dysglycaemia was 82%. We found no robust associations between chronic dysglycaemia and clinical outcomes when accounting for treatment limitations.", "doi": "10.1136/bmjopen-2022-071330", "pmid": "37730398", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10510869"}, {"db": "pii", "key": "bmjopen-2022-071330"}], "notes": [], "created": "2023-10-06T06:56:14.282Z", "modified": "2023-10-06T11:14:23.235Z"}, {"entity": "publication", "iuid": "f33ccda0af204b66985f5a33d4c2b538", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f33ccda0af204b66985f5a33d4c2b538.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f33ccda0af204b66985f5a33d4c2b538"}}, "title": "The effect of COVID-19 pandemic on perioperative factors: data from the Swedish Perioperative Register.", "authors": [{"family": "Dahlberg", "given": "Karuna", "initials": "K"}, {"family": "M\u00e5nsson", "given": "Sandra", "initials": "S"}, {"family": "Lyckner", "given": "Sara", "initials": "S"}, {"family": "Lindgren", "given": "Lenita", "initials": "L"}, {"family": "Alm", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2023-09-16", "journal": {"title": "Perioper Med (Lond)", "issn": "2047-0525", "issn-l": null, "volume": "12", "issue": "1", "pages": "50"}, "abstract": "The COVID-19 pandemic has affected healthcare organizations in many areas. The aim of this study was to describe surgical interventions, anesthesia, and postoperative outcomes in adult patients during the first wave and 1 year into the COVID-19 pandemic in Sweden, and to compare these outcomes with outcomes during the same period the year before the pandemic.\r\n\r\nData were collected from the Swedish PeriOperative Register, and included 417, 233 perioperative registration of patients \u2265 18 years old between period 1 (March-June 2019), period 2 (March-June 2020), and period 3 (March-June 2021).\r\n\r\nCompared with pre-pandemic (period 1), the number of surgical interventions decreased by 28% in the first wave (period 2); 1 year into the pandemic (period 3), the number of interventions was still 7.5% lower than pre-pandemic. The largest drops between periods 1 and 2 were noted in the specialties of ear, nose, and larynx surgery, - 55.6%; teeth, jaws, mouth, and pharynx surgery, - 45.0%; endocrine system surgery, - 38.8%. The number of acute surgeries remained stable during all three periods. Volatiles were more frequently used for the maintenance of general anesthesia in period 2 than in either period 1 or 3 (p < 0.001). Minor differences were noted throughout the periods in postoperative nausea and vomiting as well as postoperative pain.\r\n\r\nThe COVID-19 pandemic has had an impact on perioperative care in Sweden. During the first wave of the pandemic, the number of surgical interventions decreased, but the number of acute surgeries remained stable compared with pre-pandemic numbers. Perioperative organizations have had and will continue to have challenges handling the increased number of patients needing perioperative care.", "doi": "10.1186/s13741-023-00340-0", "pmid": "37715220", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10504757"}, {"db": "pii", "key": "10.1186/s13741-023-00340-0"}], "notes": [], "created": "2023-10-06T06:56:04.609Z", "modified": "2023-10-06T11:03:20.841Z"}, {"entity": "publication", "iuid": "3ad2fcacd1ce42d7b2baae5a8fdf22d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ad2fcacd1ce42d7b2baae5a8fdf22d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ad2fcacd1ce42d7b2baae5a8fdf22d5"}}, "title": "3D printed fluidic swab for COVID-19 testing with improved diagnostic yield and user comfort.", "authors": [{"family": "Kim", "given": "Joochan", "initials": "J"}, {"family": "Jeon", "given": "Jaehyung", "initials": "J"}, {"family": "Jang", "given": "Hyowon", "initials": "H"}, {"family": "Moon", "given": "Youngkwang", "initials": "Y"}, {"family": "Abafogi", "given": "Abdurhaman Teyib", "initials": "AT"}, {"family": "van Noort", "given": "Danny", "initials": "D"}, {"family": "Lee", "given": "Jinkee", "initials": "J"}, {"family": "Kang", "given": "Taejoon", "initials": "T"}, {"family": "Park", "given": "Sungsu", "initials": "S", "orcid": "0000-0003-3062-1302", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b28d5fc9ffb046f7abe638dafddade3d.json"}}], "type": "journal article", "published": "2023-09-16", "journal": {"title": "Nano Converg", "issn": "2196-5404", "issn-l": null, "volume": "10", "issue": "1", "pages": "45"}, "abstract": "The current standard method of diagnosing coronavirus disease 2019 (COVID-19) involves uncomfortable and invasive nasopharyngeal (NP) sampling using cotton swabs (CS), which can be unsuitable for self-testing. Although mid-turbinate sampling is an alternative, it has a lower diagnostic yield than NP sampling. Nasal wash (NW) has a similar diagnostic yield to NP sampling, but is cumbersome to perform. In this study, we introduce a 3D printed fluidic swab (3DPFS) that enables easy NW sampling for COVID-19 testing with improved diagnostic yield. The 3DPFS comprises a swab head, microchannel, and socket that can be connected to a syringe containing 250 \u00b5L of NW solution. The 3DPFS efficiently collects nasal fluid from the surface of the nasal cavity, resulting in higher sensitivity than CS for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This was confirmed by both reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and lateral flow assays (LFA) in virus-spiked nasal samples and clinical samples. Additionally, users reported greater comfort when using the 3DPFS compared to CS. These findings suggest that the 3DPFS can improve the performance of COVID-19 testing by facilitating efficient and less painful nasal sample collection.", "doi": "10.1186/s40580-023-00393-3", "pmid": "37715925", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10505115"}, {"db": "pii", "key": "10.1186/s40580-023-00393-3"}], "notes": [], "created": "2023-10-06T06:52:38.148Z", "modified": "2023-10-06T09:42:51.637Z"}, {"entity": "publication", "iuid": "3a6b1ba2f32c4f01b56d2579e63069f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a6b1ba2f32c4f01b56d2579e63069f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a6b1ba2f32c4f01b56d2579e63069f8"}}, "title": "The impact of reduced worry on general functioning: A mediation analysis from a randomized trial.", "authors": [{"family": "Andersson", "given": "Erik", "initials": "E", "orcid": "0000-0003-0088-8719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5bd630b521ea445ca28887ae1f5d20b4.json"}}, {"family": "Mataix-Cols", "given": "David", "initials": "D"}, {"family": "Lauri", "given": "Klara Olofsdotter", "initials": "KO"}, {"family": "de Schipper", "given": "Elles", "initials": "E"}, {"family": "Lj\u00f3tsson", "given": "Brj\u00e1nn", "initials": "B"}, {"family": "Aspvall", "given": "Kristina", "initials": "K"}, {"family": "Wahlund", "given": "Tove", "initials": "T"}], "type": "journal article", "published": "2023-09-14", "journal": {"title": "Stress Health", "issn": "1532-2998", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Previous lab findings have indicated that excessive worry may impair cognitive performance and problem solving capabilities but it is unclear if excessive worry also leads to broader impairments in general functioning. We report a secondary process data analysis of a large randomized waitlist-controlled trial (N = 670) of a self-guided online psychological intervention for dysfunctional worry related to the Covid-19 pandemic. Specific aims were to investigate (1) if improvements in general functioning were mediated by reductions in worry related to Covid-19 during the acute intervention phase, and (2) if reduced worry related to Covid-19 during acute intervention phase had a positive long-term impact on general functioning up to 1 year after the end of the intervention. To address aim 1, we used a mediation analysis framework where outcome (general functioning measured with an adapted version of the Work and Social Adjustment Scale) and the hypothesized mediator (worry measured with an adapted version of the Generalised Anxiety Disorder 7-Item Scale) were administered weekly during the controlled phase of the trial of 3 weeks. To address aim 2, we investigated if reductions in worry during the 3-week treatment period predicted improved general functioning at 1- and 12 months after treatment completion. Results showed that improvements in general functioning at week 3 were mediated by reductions in worry during the first 2 weeks of treatment (indirect effect estimate -0.08; 95% CI -0.15, -0.02). A sensitivity analysis indicated that the mediation effects dropped significantly when the residual correlation values between the mediator and the outcome exceeded r = 0. A reversed causation model was not significant. Additionally, reductions in worry during treatment predicted subsequent improvements in general functioning at both 1- and 12-month follow-ups (p < .05, -.001). Altogether, these results provide further support of the importance of targeting worry as a way to improve functioning among the large population of individuals with high levels of worry.", "doi": "10.1002/smi.3319", "pmid": "37706604", "labels": {"Type: Journal article": null, "Funder: Vinnova": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:56:31.383Z", "modified": "2023-10-06T11:18:41.186Z"}, {"entity": "publication", "iuid": "b2ea537b86cd48ad914e5398382be59f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b2ea537b86cd48ad914e5398382be59f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b2ea537b86cd48ad914e5398382be59f"}}, "title": "Temporal trends in hospitalizations and 30-day mortality in older patients during the COVID pandemic from March 2020 to July 2021.", "authors": [{"family": "Garcia-Ptacek", "given": "Sara", "initials": "S"}, {"family": "Xu", "given": "Hong", "initials": "H", "orcid": "0000-0002-7266-3431", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3aac746da836497ea13b648daac184b9.json"}}, {"family": "Annetorp", "given": "Martin", "initials": "M"}, {"family": "Jerlardtz", "given": "Viktoria B\u00e4ck", "initials": "VB"}, {"family": "Cederholm", "given": "Tommy", "initials": "T"}, {"family": "Engstr\u00f6m", "given": "Malin", "initials": "M"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Lundberg", "given": "Lars G\u00f6ran", "initials": "LG"}, {"family": "Metzner", "given": "Carina", "initials": "C"}, {"family": "Olsson", "given": "Maria", "initials": "M"}, {"family": "Nyvang", "given": "Josefina Skog\u00f6", "initials": "JS"}, {"family": "S\u00fchl \u00d6berg", "given": "Carina", "initials": "C"}, {"family": "\u00c5kesson", "given": "Elisabet", "initials": "E"}, {"family": "Religa", "given": "Dorota", "initials": "D"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2023-09-14", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "9", "pages": "e0291237"}, "abstract": "A reduction in mortality risk of COVID-19 throughout the first wave of the pandemic has been reported, but less is known about later waves. This study aimed to describe changes in hospitalizations and mortality of patients receiving inpatient geriatric care for COVID-19 or other causes during the pandemic.\r\n\r\nPatients 70 years and older hospitalized in geriatric hospitals in Stockholm for COVID-19 or other causes between March 2020-July 2021 were included. Data on the incidence of COVID-positive cases and 30-day mortality of the total \u2265 70-year-old population, in relation to weekly hospitalizations and mortality after hospital admissions were analyzed. Findings The total number of hospitalizations was 5,320 for COVID-19 and 32,243 for non-COVID-cases. In COVID-patients, the 30-day mortality rate was highest at the beginning of the first wave (29% in March-April 2020), reached 17% at the second wave peak (November-December) followed by 11-13% in the third wave (March-July 2021). The mortality in non-COVID geriatric patients showed a similar trend, but of lower magnitude (5-10%). During the incidence peaks, COVID-19 hospitalizations displaced non-COVID geriatric patients.\r\n\r\nHospital admissions and 30-day mortality after hospitalizations for COVID-19 increased in periods of high community transmission, albeit with decreasing mortality rates from wave 1 to 3, with a probable vaccination effect in wave 3. Thus, the healthcare system could not compensate for the high community spread of COVID-19 during the pandemic peaks, which also led to displacing care for non-COVID geriatric patients.", "doi": "10.1371/journal.pone.0291237", "pmid": "37708110", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10501674"}, {"db": "pii", "key": "PONE-D-22-12713"}], "notes": [], "created": "2023-09-18T16:00:46.524Z", "modified": "2023-10-06T09:58:21.706Z"}, {"entity": "publication", "iuid": "12ec45c4a43444138c0f4a53b788417a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/12ec45c4a43444138c0f4a53b788417a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/12ec45c4a43444138c0f4a53b788417a"}}, "title": "Symptoms, care consumption, and healthcare costs in hospitalized patients during the first wave of the COVID-19 pandemic.", "authors": [{"family": "Ashman Kr\u00f6\u00f6nstr\u00f6m", "given": "Linda", "initials": "L", "orcid": "0000-0002-4148-4844", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b0b88c35426e4eab9f7ee67e704cf5cf.json"}}, {"family": "Lundgren-Nilsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Kjellby-Wendt", "given": "Gunilla", "initials": "G"}, {"family": "Stibrant Sunnerhagen", "given": "Katharina", "initials": "K"}], "type": "observational study", "published": "2023-09-14", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "9", "pages": "e0291548"}, "abstract": "We aimed to assess symptomatology post discharge from the hospital in patients with COVID-19 treated during the first wave of the COVID-19 pandemic, and to follow care consumption and healthcare costs six months post discharge.\r\n\r\nThis study was a descriptive observational study over time. Data were retrieved from the Sahlgrenska University (SU) hospital registry for patients admitted to an SU hospital during March 2020 to August 2020. Of these, 1014 received a questionnaire approximately six weeks post discharge regarding symptoms. Data regarding care consumption were retrieved from the registry in the Region V\u00e4stra G\u00f6taland for 529 (52.2%) patients who completed the questionnaire. Of these, 466 patients were included in the analysis of care consumption.\r\n\r\nThere was a reported decrease in mobility from admission to discharge in both men (p = 0.02) and women (p = 0.01). The costs of inpatient care amounted to a total of 9 601 459.20 Euro (EUR). Symptoms were reported in 436 (93.6%) patients post discharge, of which weight loss during COVID-19 was most common in both men (n = 220, 77.5%) and women (n = 107, 58.8%). During six-month follow-up, 409 (87%) patients consumed care. Of the registered visits, 868 (27.1%) were related to a COVID-19 diagnosis. The total sum of outpatient care (i.e. visits with a registered COVID-19 diagnosis) was 77 311.30 EUR.\r\n\r\nAt discharge from the hospital, there was a decrease in mobility. Most patients had remaining sequelae post discharge. At six months post discharge, nearly 90% of patients had consumed care, with approximately 20% related to COVID-19. This indicates a persisting need for rehabilitation post discharge from hospital in patients treated for COVID-19.", "doi": "10.1371/journal.pone.0291548", "pmid": "37708157", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10501636"}, {"db": "pii", "key": "PONE-D-23-18622"}], "notes": [], "created": "2023-10-06T06:52:58.476Z", "modified": "2023-10-06T10:43:03.121Z"}, {"entity": "publication", "iuid": "ac117d7f4cd745d5903004c4a12e5fef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac117d7f4cd745d5903004c4a12e5fef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac117d7f4cd745d5903004c4a12e5fef"}}, "title": "SARS-CoV-2-related mortality decrease in nursing home residents given multiple COVID-19 boosters.", "authors": [{"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Fj\u00e4llstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Moln\u00e1r", "given": "Christian", "initials": "C"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Vikstr\u00f6m", "given": "Linnea", "initials": "L"}, {"family": "Wigren-Bystr\u00f6m", "given": "Julia", "initials": "J"}, {"family": "Bennet", "given": "Louise", "initials": "L"}, {"family": "Widerstr\u00f6m", "given": "Micael", "initials": "M"}, {"family": "Rasmussen", "given": "Gunl\u00f6g", "initials": "G"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}], "type": "letter", "published": "2023-09-13", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/S1473-3099(23)00548-0", "pmid": "37716359", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(23)00548-0"}], "notes": [], "created": "2023-09-18T15:57:53.001Z", "modified": "2023-09-18T15:58:15.616Z"}, {"entity": "publication", "iuid": "160e70d0a33f483e8aa20c2ea5a59fd2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/160e70d0a33f483e8aa20c2ea5a59fd2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/160e70d0a33f483e8aa20c2ea5a59fd2"}}, "title": "Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.", "authors": [{"family": "Mihali\u010d", "given": "Filip", "initials": "F", "orcid": "0000-0002-6840-2319", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9750b70b9a374be18d94abbc82fa5bbc.json"}}, {"family": "Benz", "given": "Caroline", "initials": "C", "orcid": "0000-0002-5166-3598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13332514bfe7460db4a0f134718aa211.json"}}, {"family": "Kassa", "given": "Eszter", "initials": "E"}, {"family": "Lindqvist", "given": "Richard", "initials": "R"}, {"family": "Simonetti", "given": "Leandro", "initials": "L", "orcid": "0000-0003-1283-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9ef81e96c104878a6ccea620fc95400.json"}}, {"family": "Inturi", "given": "Raviteja", "initials": "R"}, {"family": "Aronsson", "given": "Hanna", "initials": "H"}, {"family": "Andersson", "given": "Eva", "initials": "E"}, {"family": "Chi", "given": "Celestine N", "initials": "CN"}, {"family": "Davey", "given": "Norman E", "initials": "NE"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK", "orcid": "0000-0001-6553-0940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9024ab251cf44bffbf3229ec909343af.json"}}, {"family": "Jemth", "given": "Per", "initials": "P", "orcid": "0000-0003-1516-7228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c5fe566cf5f44df9c98bb2b1d7078ba.json"}}, {"family": "Ivarsson", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-7081-3846", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b3cf0504a1b476f906c4b3e22b05d5a.json"}}], "type": "journal article", "published": "2023-09-13", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "14", "issue": "1", "pages": "5636"}, "abstract": "The virus life cycle depends on host-virus protein-protein interactions, which often involve a disordered protein region binding to a folded protein domain. Here, we used proteomic peptide phage display (ProP-PD) to identify peptides from the intrinsically disordered regions of the human proteome that bind to folded protein domains encoded by the SARS-CoV-2 genome. Eleven folded domains of SARS-CoV-2 proteins were found to bind 281 peptides from human proteins, and affinities of 31 interactions involving eight SARS-CoV-2 protein domains were determined (KD \u223c 7-300 \u03bcM). Key specificity residues of the peptides were established for six of the interactions. Two of the peptides, binding Nsp9 and Nsp16, respectively, inhibited viral replication. Our findings demonstrate how high-throughput peptide binding screens simultaneously identify potential host-virus interactions and peptides with antiviral properties. Furthermore, the high number of low-affinity interactions suggest that overexpression of viral proteins during infection may perturb multiple cellular pathways.", "doi": "10.1038/s41467-023-41312-8", "pmid": "37704626", "labels": {"Type: Journal article": null, "Category: Proteins": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10499821"}, {"db": "pii", "key": "10.1038/s41467-023-41312-8"}], "notes": [], "created": "2023-09-18T15:51:27.180Z", "modified": "2023-10-06T11:29:41.684Z"}, {"entity": "publication", "iuid": "0fd16b7d2ef24af1b02e8409dd48f602", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0fd16b7d2ef24af1b02e8409dd48f602.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0fd16b7d2ef24af1b02e8409dd48f602"}}, "title": "Identification of essential genes associated with SARS-CoV-2 infection as potential drug target candidates with machine learning algorithms.", "authors": [{"family": "Taheri", "given": "Golnaz", "initials": "G"}, {"family": "Habibi", "given": "Mahnaz", "initials": "M"}], "type": "journal article", "published": "2023-09-13", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "15141"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires the fast discovery of effective treatments to fight this worldwide concern. Several genes associated with the SARS-CoV-2, which are essential for its functionality, pathogenesis, and survival, have been identified. These genes, which play crucial roles in SARS-CoV-2 infection, are considered potential therapeutic targets. Developing drugs against these essential genes to inhibit their regular functions could be a good approach for COVID-19 treatment. Artificial intelligence and machine learning methods provide powerful infrastructures for interpreting and understanding the available data and can assist in finding fast explanations and cures. We propose a method to highlight the essential genes that play crucial roles in SARS-CoV-2 pathogenesis. For this purpose, we define eleven informative topological and biological features for the biological and PPI networks constructed on gene sets that correspond to COVID-19. Then, we use three different unsupervised learning algorithms with different approaches to rank the important genes with respect to our defined informative features. Finally, we present a set of 18 important genes related to COVID-19. Materials and implementations are available at: https://github.com/MahnazHabibi/Gene_analysis .", "doi": "10.1038/s41598-023-42127-9", "pmid": "37704748", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Genomics & transcriptomics": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC10499814"}, {"db": "pii", "key": "10.1038/s41598-023-42127-9"}], "notes": [], "created": "2023-10-06T06:52:11.207Z", "modified": "2023-10-06T08:24:45.259Z"}, {"entity": "publication", "iuid": "ee8a417d0c014b54b315229da0a7672b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee8a417d0c014b54b315229da0a7672b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee8a417d0c014b54b315229da0a7672b"}}, "title": "Psychological distress and musculoskeletal pain in manual therapists during the second wave of the COVID-19 pandemic in Sweden: a cross-sectional study.", "authors": [{"family": "Weiss", "given": "Nathan", "initials": "N", "orcid": "0000-0002-1814-020X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd09b882d55a45d78c868e6fd116d660.json"}}, {"family": "Skillgate", "given": "Eva", "initials": "E"}, {"family": "Ax\u00e9n", "given": "Iben", "initials": "I"}], "type": "journal article", "published": "2023-09-12", "journal": {"title": "Chiropr Man Therap", "issn": "2045-709X", "issn-l": "2045-709X", "volume": "31", "issue": "1", "pages": "34"}, "abstract": "The COVID-19 pandemic had an unprecedented impact on healthcare, and the health of healthcare workers has been subject of much research. However, studies of health-related factors in manual therapists during the COVID-19 pandemic are scarce. Research in this field can provide valuable insights for future crises policy and guidelines, including in regions where the public health response to COVID-19 contrasts with that of most other international jurisdictions. The aim was to describe the prevalence of psychological distress and musculoskeletal pain, and to investigate factors potentially associated with high psychological distress and activity-limiting musculoskeletal pain in clinically active chiropractors and naprapaths during the second wave of the COVID-19 pandemic in Sweden.\r\n\r\nA cross-sectional survey was distributed to a representative sample of Swedish manual therapists, between November 2020 and January 2021. High psychological distress and activity-limiting musculoskeletal pain were investigated regarding associations with residing in a municipality with a high spread of infection, a previous/ongoing SARS-CoV-2 infection, clinical interferences and economic consequences associated with the pandemic. Generalized Linear Models with log link and binomial distribution were used, computing prevalence ratios (PR) with 95% confidence intervals (95% CI).\r\n\r\nA total of 762 participants were included, representing 46% of the source population. The prevalence of depressive, anxiety, and stress symptoms was 17%, 7%, and 12%, respectively. Neck (50%), low back (46%), upper back (40%), and shoulders (39%) were the most prevalent musculoskeletal pain areas. Economic consequences due to the pandemic were associated with high psychological distress (PR = 2.30, 95% CI: 1.48-3.53).\r\n\r\nDuring the second wave of the COVID-19 pandemic in Sweden, manual therapists primarily suffered from musculoskeletal pain related to the back and shoulders, while depressive symptoms were the most common symptom of psychological distress. Owners of businesses that suffered economic consequences had a higher prevalence of high psychological distress, which may call for targeted support of this group in future similar contexts. Future longitudinal studies during the pandemic are warranted to assess these associations further.", "doi": "10.1186/s12998-023-00511-2", "pmid": "37700309", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10498599"}, {"db": "pii", "key": "10.1186/s12998-023-00511-2"}], "notes": [], "created": "2023-10-06T06:52:30.019Z", "modified": "2023-10-06T09:41:12.833Z"}, {"entity": "publication", "iuid": "4e51eab6d2f54fce8ef5f19b576cf214", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4e51eab6d2f54fce8ef5f19b576cf214.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4e51eab6d2f54fce8ef5f19b576cf214"}}, "title": "Comparative effectiveness of mRNA-1273 and BNT162b2 COVID-19 vaccines in immunocompromised individuals: a systematic review and meta-analysis using the GRADE framework.", "authors": [{"family": "Wang", "given": "Xuan", "initials": "X"}, {"family": "Haeussler", "given": "Katrin", "initials": "K"}, {"family": "Spellman", "given": "Anne", "initials": "A"}, {"family": "Phillips", "given": "Leslie E", "initials": "LE"}, {"family": "Ramiller", "given": "Allison", "initials": "A"}, {"family": "Bausch-Jurken", "given": "Mary T", "initials": "MT"}, {"family": "Sharma", "given": "Pawana", "initials": "P"}, {"family": "Krivelyova", "given": "Anna", "initials": "A"}, {"family": "Vats", "given": "Sonam", "initials": "S"}, {"family": "Van de Velde", "given": "Nicolas", "initials": "N"}], "type": "meta-analysis", "published": "2023-09-12", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "1204831"}, "abstract": "Despite representing only 3% of the US population, immunocompromised (IC) individuals account for nearly half of the COVID-19 breakthrough hospitalizations. IC individuals generate a lower immune response after vaccination in general, and the US CDC recommended a third dose of either mRNA-1273 or BNT162b2 COVID-19 vaccines as part of their primary series. Influenza vaccine trials have shown that increasing dosage could improve effectiveness in IC populations. The objective of this systematic literature review and pairwise meta-analysis was to evaluate the clinical effectiveness of mRNA-1273 (50 or 100 mcg/dose) vs BNT162b2 (30 mcg/dose) in IC populations using the GRADE framework.\r\n\r\nThe systematic literature search was conducted in the World Health Organization COVID-19 Research Database. Studies were included in the pairwise meta-analysis if they reported comparisons of mRNA-1273 and BNT162b2 in IC individuals \u226518 years of age; outcomes of interest were symptomatic, laboratory-confirmed SARS-CoV-2 infection, SARS-CoV-2 infection, severe SARS-CoV-2 infection, hospitalization due to COVID-19, and mortality due to COVID-19. Risk ratios (RR) were pooled across studies using random-effects meta-analysis models. Outcomes were also analyzed in subgroups of patients with cancer, autoimmune disease, and solid organ transplant. Risk of bias was assessed using the Newcastle-Ottawa Scale for observational studies. Evidence was evaluated using the GRADE framework.\r\n\r\nOverall, 17 studies were included in the pairwise meta-analysis. Compared with BNT162b2, mRNA-1273 was associated with significantly reduced risk of SARS-CoV-2 infection (RR, 0.85 [95% CI, 0.75-0.97]; P=0.0151; I67.7%), severe SARS-CoV-2 infection (RR, 0.85 [95% CI, 0.77-0.93]; 2 = P=0.0009; I0%), COVID-19-associated hospitalization (RR, 0.88 [95% CI, 0.79-0.97]; 2 = P<0.0001; I0%), and COVID-19-associated mortality (RR, 0.63 [95% CI, 0.44-0.90]; 2 = P=0.0119; I0%) in IC populations. Results were consistent across subgroups. Because of sample size limitations, relative effectiveness of COVID-19 mRNA vaccines in IC populations cannot be studied in randomized trials. Based on nonrandomized studies, evidence certainty among comparisons was type 3 (low) and 4 (very low), reflecting potential biases in observational studies.2 =\r\n\r\nThis GRADE meta-analysis based on a large number of consistent observational studies showed that the mRNA-1273 COVID-19 vaccine is associated with improved clinical effectiveness in IC populations compared with BNT162b2.", "doi": "10.3389/fimmu.2023.1204831", "pmid": "37771594", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10523015"}], "notes": [], "created": "2023-10-06T06:52:18.225Z", "modified": "2023-10-06T08:46:46.071Z"}, {"entity": "publication", "iuid": "f707cac0c9ec4fc6b4115fc65fd5538d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f707cac0c9ec4fc6b4115fc65fd5538d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f707cac0c9ec4fc6b4115fc65fd5538d"}}, "title": "COVID-19 outcomes in patients with a history of immune-mediated glomerular diseases.", "authors": [{"family": "Gauckler", "given": "Philipp", "initials": "P"}, {"family": "Kesenheimer", "given": "Jana S", "initials": "JS"}, {"family": "Geetha", "given": "Duvuru", "initials": "D"}, {"family": "Odler", "given": "Balazs", "initials": "B"}, {"family": "Eller", "given": "Kathrin", "initials": "K"}, {"family": "Laboux", "given": "Timothee", "initials": "T"}, {"family": "Alberici", "given": "Federico", "initials": "F"}, {"family": "Zappa", "given": "Mattia", "initials": "M"}, {"family": "Chebotareva", "given": "Natasha", "initials": "N"}, {"family": "Moiseev", "given": "Sergey", "initials": "S"}, {"family": "Bonilla", "given": "Marco", "initials": "M"}, {"family": "Jhaveri", "given": "Kenar D", "initials": "KD"}, {"family": "Oniszczuk", "given": "Julie", "initials": "J"}, {"family": "Audard", "given": "Vincent", "initials": "V"}, {"family": "Costa", "given": "Denise", "initials": "D"}, {"family": "Mastroianni-Kirsztajn", "given": "Gianna", "initials": "G"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Muto", "given": "Masahiro", "initials": "M"}, {"family": "Windpessl", "given": "Martin", "initials": "M"}, {"family": "Mayer", "given": "Gert", "initials": "G"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2023-09-12", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "1228457"}, "abstract": "Patients with immune-mediated glomerular diseases are considered at high risk for severe COVID-19 outcomes. However, conclusive evidence for this patient population is scarce.\r\n\r\nWe created a global registry and retrospectively collected clinical data of patients with COVID-19 and a previously diagnosed immune-mediated glomerular disease to characterize specific risk factors for severe COVID-19 outcomes.\r\n\r\nFifty-nine patients with a history of immune-mediated glomerular diseases were diagnosed with COVID-19 between 01.03.2020 and 31.08.2021. Over a mean follow-up period of 24.79 \u00b1 18.89 days, ten patients (16.9%) developed acute kidney injury. Overall, 44.1% of patients were managed in an outpatient setting and therefore considered as having \"non-severe\" COVID-19, while 55.9% of patients had severe COVID-19 requiring hospitalization including worse outcomes. Comparing both groups, patients with severe COVID-19 were significantly older (53.55 \u00b1 17.91 versus 39.77 \u00b1 14.95 years, p = .003), had lower serum albumin levels at presentation (3.00 \u00b1 0.80 g/dL versus 3.99 \u00b1 0.68 g/dL, p = .016) and had a higher risk of developing acute kidney injury (27% versus 4%, p = .018). Male sex (p <.001) and ongoing intake of corticosteroids at presentation (p = .047) were also significantly associated with severe COVID-19 outcomes, while the overall use of ongoing immunosuppressive agents and glomerular disease remission status showed no significant association with the severity of COVID-19 (p = .430 and p = .326, respectively).\r\n\r\nOlder age, male sex, ongoing intake of corticosteroids and lower serum albumin levels at presentation were identified as risk factors for severe COVID-19 outcomes in patients with a history of various immune-mediated glomerular diseases.", "doi": "10.3389/fimmu.2023.1228457", "pmid": "37767096", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10520971"}], "notes": [], "created": "2023-10-06T06:55:31.187Z", "modified": "2023-10-06T10:56:25.611Z"}, {"entity": "publication", "iuid": "fde482edb3254b7aa40775042bfddfbf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fde482edb3254b7aa40775042bfddfbf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fde482edb3254b7aa40775042bfddfbf"}}, "title": "Type 1 diabetes, COVID-19 vaccines and short-term safety: Subgroup analysis from the global COVAD study.", "authors": [{"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Ravichandran", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Nair", "given": "Narmadha", "initials": "N"}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Barman", "given": "Bhupen", "initials": "B", "orcid": "0000-0002-5433-1310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7747785ec5fa4743bc70bd20fbca10fd.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Saha", "given": "Sreoshy", "initials": "S", "orcid": "0000-0001-6745-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00238845dd4833ae51ffb75e2fe144.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Pande", "given": "Arun Kumar R", "initials": "AKR", "orcid": "0000-0002-9570-1509", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ffc8a0aa37c14dffb457a50cd61740d5.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Boro", "given": "Hiya", "initials": "H"}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "COVAD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-09-11", "journal": {"title": "J Diabetes Investig", "issn": "2040-1124", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Coronavirus disease 2019 (COVID-19) vaccinations have been proven to be generally safe in healthy populations. However, the data on vaccine safety in patients with type 1 diabetes are scarce. This study aimed to evaluate the frequency and severity of short-term (<7-day) adverse vaccination events (AEs) and their risk factors among type 1 diabetes patients.\r\n\r\nThis study analyzed data from the COVID-19 vaccination in Autoimmune Diseases (COVAD) survey database (May to December 2021; 110 collaborators, 94 countries), comparing <7-day COVID-19 vaccine AE among type 1 diabetes patients and healthy controls (HCs). Descriptive statistics; propensity score matching (1:4) using the variables age, sex and ethnicity; and multivariate analyses were carried out.\r\n\r\nThis study analyzed 5,480 completed survey responses. Of all responses, 5,408 were HCs, 72 were type 1 diabetes patients (43 females, 48.0% white European ancestry) and Pfizer was the most administered vaccine (39%). A total of 4,052 (73.9%) respondents had received two vaccine doses. Patients with type 1 diabetes had a comparable risk of injection site pain, minor and major vaccine AEs, as well as associated hospitalizations to HCs. However, type 1 diabetes patients had a higher risk of severe rashes (3% vs 0.4%, OR 8.0, 95% confidence interval 1.7-36), P = 0.007), although reassuringly, these were rare (n = 2 among type 1 diabetes patients).\r\n\r\nCOVID-19 vaccination was safe and well tolerated in patients with type 1 diabetes with similar AE profiles compared with HCs, although severe rashes were more common in type 1 diabetes patients.", "doi": "10.1111/jdi.14079", "pmid": "37697820", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:56:49.199Z", "modified": "2023-10-06T11:30:56.100Z"}, {"entity": "publication", "iuid": "6eb4985c19994970802917859c7bf524", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6eb4985c19994970802917859c7bf524.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6eb4985c19994970802917859c7bf524"}}, "title": "Gambling helpline contacts during COVID-19-related availability restrictions: an interrupted time series analysis.", "authors": [{"family": "Wall", "given": "H", "initials": "H"}, {"family": "Kristiansen", "given": "S", "initials": "S"}, {"family": "Molander", "given": "O", "initials": "O"}, {"family": "Forsstr\u00f6m", "given": "D", "initials": "D"}, {"family": "Marionneau", "given": "V", "initials": "V"}], "type": "journal article", "published": "2023-09-09", "journal": {"title": "Public Health", "issn": "1476-5616", "issn-l": null, "volume": "224", "issue": null, "pages": "14-19"}, "abstract": "Gambling causes significant public health harms that are addressed in the help service network. Helplines are the most widely used service among those experiencing harms. The COVID-19 pandemic changed the global gambling landscape. This study assesses the effect of COVID-19-related restrictions on help-seeking for gambling via helplines.\r\n\r\nWe analysed data of national helplines in Sweden, Finland, and Denmark before and during the pandemic. The countries differed in their restrictions on the availability and accessibility of gambling during the pandemic.\r\n\r\nWe performed an interrupted time series analysis of contact and web traffic data to helplines in Sweden, Finland, and Denmark before and during the COVID-19 pandemic (2017-2021). We also compared forecasted time series to the actual data to assess change.\r\n\r\nThe results show diverging patterns across the three countries. In Sweden, the number of helpline contacts remained stable throughout COVID-19, but there was an increasing trend in website visits. In Finland, the number of contacts declined during the first wave but rebounded during the second wave. Website visitation increased moderately. In Denmark, the number of contacts to the helpline soared over the COVID-19 period.\r\n\r\nThe diverging results suggest that help-seeking behaviour is likely to be impacted by differing policy approaches to gambling availability and limit-setting, visibility of helplines, and the prevalence of different forms of gambling in the three Nordic countries before and during the pandemic. This has implications for a preventive public health approach for gambling.", "doi": "10.1016/j.puhe.2023.08.013", "pmid": "37696197", "labels": {"Type: Journal article": null, "Funder: Forte": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0033-3506(23)00296-2"}], "notes": [], "created": "2023-10-06T06:55:19.376Z", "modified": "2023-10-06T10:50:22.910Z"}, {"entity": "publication", "iuid": "3a916267a8004d29a0603ec71f47c07f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a916267a8004d29a0603ec71f47c07f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a916267a8004d29a0603ec71f47c07f"}}, "title": "Antibiotic prescriptions among dentists across Norway and the impact of COVID-19 pandemic.", "authors": [{"family": "Tousi", "given": "Farnoush", "initials": "F"}, {"family": "Al Haroni", "given": "Mohammed", "initials": "M"}, {"family": "Lie", "given": "Stein Atle", "initials": "SA"}, {"family": "Lund", "given": "Bodil", "initials": "B"}], "type": "journal article", "published": "2023-09-08", "journal": {"title": "BMC Oral Health", "issn": "1472-6831", "issn-l": null, "volume": "23", "issue": "1", "pages": "649"}, "abstract": "The prescription of antibiotics in dental practice contributes significantly to the total use of antibiotics in primary healthcare. This study aimed to evaluate antibiotic prescription in dental practice during the years 2016-2021 in Norway and their relative contribution to national outpatient consumption and to investigate the influence of age, gender, geographic region, and COVID-19. A further aim was to review differences in prescribing patterns to verify effect of governmental strategies to reduce over-prescribing of antibiotics.\r\n\r\nThis register study investigated the national antibiotic prescription between 2016 and 2021. Data was obtained from the Norwegian prescription register, the Norwegian Institute of Public Health and Statistics Norway. The consumption of 12 common antibiotics was measured using WHO defined daily doses (DDDs), DDD per 1000 inhabitants per day (DIDs 1000).\r\n\r\nA total of 6,049,445 antibiotic prescriptions of the 12 investigated compounds were issued in primary care during the study period. Dentists accounted for 942,350 prescriptions corresponding to 15.6% of the total. An overall decrease in the number of prescriptions by health professions other than dentists during the 5 years (IRR = 0.92, 95% CI:0.92-0.93, p < 0.001) was observed. For dentists a slight increase in the number of prescriptions (IRR = 1.01, 95% CI: 1.01-1.01, p < 0.001) was seen over the study period. The increase of antibiotic prescriptions in dentistry was more pronounced during the COVID-19 pandemic. The 4 most prescribed type of antibiotics based on average number of DDDs of the total period 2016-2021 were in descending order; phenoxymethylpenicillin (1,109,150) followed by amoxicillin (126,244), clindamycin (72,565), and metronidazole (64,599). An unexpected finding was that the prescription of the combination compound amoxicillin/clavulanic acid had significantly increased in dentistry during the last 5 years. Geographic, gender, and age differences in the rates of prescriptions were also seen. The data revealed that there are seasonal variations in dental prescriptions.\r\n\r\nNoticeable differences exist in prescribing patterns of antibiotics in the last 5 years. Restricted access to dental care due to COVID-19 may have resulted in increased antibiotic prescribing in dentistry as opposed to an otherwise downward trend. Despite national guidelines there is still a need for improvement of antibiotic stewardship in dentistry and to define effective methods to disseminate information.", "doi": "10.1186/s12903-023-03380-6", "pmid": "37684614", "labels": {"Category: Health": null, "Type: Journal article": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC10492408"}, {"db": "pii", "key": "10.1186/s12903-023-03380-6"}], "notes": [], "created": "2023-10-06T06:56:54.348Z", "modified": "2023-10-06T11:33:08.611Z"}, {"entity": "publication", "iuid": "c33bb0bd2b7a40c2a1086b25f36e79fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c33bb0bd2b7a40c2a1086b25f36e79fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c33bb0bd2b7a40c2a1086b25f36e79fd"}}, "title": "Perceptions of everyday life during lenient COVID-19 restrictions in Sweden- an interview study.", "authors": [{"family": "Lindgren", "given": "Ingrid", "initials": "I"}, {"family": "Trulsson Schouenborg", "given": "Anna", "initials": "A"}, {"family": "Larsson", "given": "Caroline", "initials": "C"}, {"family": "Stigmar", "given": "Kjerstin", "initials": "K"}], "type": "journal article", "published": "2023-09-07", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "23", "issue": "1", "pages": "1743"}, "abstract": "Both COVID-19 and its associated societal restrictions have affected individuals' health and everyday life. In Sweden, more lenient public health restrictions were implemented, with individuals asked to act responsibly in terms of reducing spread of disease. The majority of studies reporting on experiences of Covid-19 restrictions have been in the context of more substantial mandatory rules aimed at reducing social contact, therefore it is important to describe how more lenient restrictions have impacted individuals' well-being. This study aims to describe perceptions of everyday life during the first wave of the COVID-19 pandemic, perceived by individuals with no underlying medical condition, and living with more lenient public health restrictions in Sweden.\r\n\r\nThe participants were recruited from individuals who originally had participated in an online survey about life satisfaction, health, and physical activity. Fifteen individuals (median age 49, range 26-76 years, seven women) in various social situations, such as living alone/cohabiting, having children at home, geographical area and size of city were interviewed. Qualitative content analysis was applied to the data.\r\n\r\nAn overall theme \"Both hindrances and opportunities in important life domains were experienced within the same person during lenient Covid-19 restrictions\" was derived and covered three categories: \"New possibilities of flexibility in work and better health\", \"Life went on as usual with minor adjustments\" and \"Everyday life changed and became more difficult\" together with eight subcategories. For most participants, both facilitating and hindering important domains in life were described. Unexpected findings were positive experiences regarding working from home, physical activities, leisure time activities and the balance between work and leisure time. In areas where only minor adjustments were made, life was perceived as going on as before. On the other hand, restrictions increased worries and were perceived to have negative effects on social participation.\r\n\r\nThe impact of the pandemic and lenient restrictions in Sweden on the participants\u00b4 everyday life was multifaceted. Both hindrances and opportunities in important life domains were experienced within the same person. An increased flexibility in work- and leisure activities were perceived having positive effects for health and wellbeing and led to a better balance in life.", "doi": "10.1186/s12889-023-16599-3", "pmid": "37679662", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10483720"}, {"db": "pii", "key": "10.1186/s12889-023-16599-3"}], "notes": [], "created": "2023-10-06T06:56:17.554Z", "modified": "2023-10-06T11:15:12.699Z"}, {"entity": "publication", "iuid": "e4a3cefb49924dd39e8d1ba6dba2ed68", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e4a3cefb49924dd39e8d1ba6dba2ed68.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e4a3cefb49924dd39e8d1ba6dba2ed68"}}, "title": "COVID-19 pandemic hits differently: examining its consequences for women's livelihoods and healthcare access - a cross-sectional study in Kinshasa DRC.", "authors": [{"family": "Nkweleko Fankam", "given": "Falone", "initials": "F", "orcid": "0000-0001-7826-9382", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f15dd40fbc11449a8b1ab7fda57ae276.json"}}, {"family": "Ugarte", "given": "William", "initials": "W"}, {"family": "Akilimali", "given": "Pierre", "initials": "P"}, {"family": "Ewane Etah", "given": "Junior", "initials": "J"}, {"family": "\u00c5kerman", "given": "Eva", "initials": "E"}], "type": "journal article", "published": "2023-09-07", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "9", "pages": "e072869"}, "abstract": "The emergence of the COVID-19 pandemic led to multiple preventive actions as primary interventions to contain the spread of the virus. Globally, countries are facing enormous challenges with consequences for use of social, economic and health services. The Democratic Republic of Congo (DRC) was among the African countries implementing strict lockdown at the start of the pandemic, resulting in shortages and decreased access to services. The adverse effects of the pandemic had unpleasant consequences for the country. This study aimed to examine the association between COVID-19 pandemic-related factors, sociodemographic factors, and the need to visit healthcare facilities, including family planning services, among women aged 15-49 years in the DRC.\r\n\r\nWe conducted a secondary analysis of a performance monitoring for action (PMA) cross-sectional COVID-19 phone survey in Kinshasa, DRC, which had a response rate of 74.7%. In total, 1325 randomly selected women aged 15-49 years from the Kinshasa province who had previously participated in the PMA baseline survey participated in the survey. Bivariate and multivariate logistic regressions were used to assess associations.\r\n\r\nThe COVID-19 pandemic and related factors affected 92% of women in the Kinshasa province socioeconomically. A majority were highly economically dependent on their partner or some other sources for their basic needs to be met, and even more worried about the future impact of the pandemic on their household finances. Over 50% of women did not attempt visiting a health service, with some of the top reasons being fear of being infected with COVID-19 and not being able to afford services. We found a significant association between age groups and contraceptive use. The need for and use of contraceptives was higher among women aged 25-34 years than those aged 15-24 or 35-49 years.\r\n\r\nEffective social/economic support to women and girls during pandemics and in crises is essential as it can have lasting beneficial effects on many domains of their lives, including their ability to access health services and the contraceptives of their choice.", "doi": "10.1136/bmjopen-2023-072869", "pmid": "37678942", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10496687"}, {"db": "pii", "key": "bmjopen-2023-072869"}], "notes": [], "created": "2023-10-06T06:56:09.388Z", "modified": "2023-10-06T11:06:05.953Z"}, {"entity": "publication", "iuid": "6f160d0571b7441db235a4a6aa93b071", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f160d0571b7441db235a4a6aa93b071.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f160d0571b7441db235a4a6aa93b071"}}, "title": "Fresh or frozen grafts for allogeneic stem cell transplantation: conceptual considerations and a survey on the practice during the COVID-19 pandemic from the EBMT Infectious Diseases Working Party (IDWP) and Cellular Therapy & Immunobiology Working Party (CTIWP).", "authors": [{"family": "Worel", "given": "N", "initials": "N", "orcid": "0000-0002-3599-8099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0dc334f4e434fb7b018f43f56d9135c.json"}}, {"family": "Ljungman", "given": "P", "initials": "P", "orcid": "0000-0002-8281-3245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4546eb504184683ab712eee858ea9cb.json"}}, {"family": "Verheggen", "given": "I C M", "initials": "ICM"}, {"family": "Hoogenboom", "given": "J D", "initials": "JD"}, {"family": "Knelange", "given": "N S", "initials": "NS"}, {"family": "Eikema", "given": "D-J", "initials": "D"}, {"family": "S\u00e1nchez-Ortega", "given": "I", "initials": "I"}, {"family": "Riillo", "given": "C", "initials": "C"}, {"family": "Centorrino", "given": "I", "initials": "I"}, {"family": "Averbuch", "given": "D", "initials": "D", "orcid": "0000-0001-9614-7274", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/161ea7304f3046d1926a0b58ff122c98.json"}}, {"family": "Chabannon", "given": "C", "initials": "C", "orcid": "0000-0002-3755-4889", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6383ab718ee423da23a515b971751bc.json"}}, {"family": "de la Camara", "given": "R", "initials": "R", "orcid": "0000-0002-8189-5779", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/868bc0284ac640a1bf215e7d7cc86da3.json"}}, {"family": "Kuball", "given": "J", "initials": "J", "orcid": "0000-0002-3914-7806", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93b68b37f90949f681e03905510def84.json"}}, {"family": "Ruggeri", "given": "A", "initials": "A", "orcid": "0000-0002-7261-2765", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22584a74a4864481acc0ef4c17f12fc7.json"}}], "type": "journal article", "published": "2023-09-06", "journal": {"title": "Bone Marrow Transplant", "issn": "1476-5365", "issn-l": "0268-3369", "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic has had a significant impact on medical practices, including the delivery of allogeneic hematopoietic cell transplantation (HCT). In response, transplant centers have made changes to their procedures, including an increased use of cryopreservation for allogeneic haematopoietic progenitor cell (HPC) grafts. The use of cryopreserved grafts for allogeneic HCT has been reviewed and analysed in terms of potential benefits and drawbacks based on existing data on impact on cell subsets, hematological recovery, and clinical outcomes of approximately 2000 patients from different studies. A survey of European Society for Blood and Marrow Transplantation centers was also conducted to assess changes in practice during the pandemic and any unnecessary burdens on HPC donors. Before the pandemic, only 7.4% of transplant centers were routinely cryopreserving HPC products, but this percentage increased to 90% during the pandemic. The results of this review and survey suggest that cryopreservation of HPC grafts is a viable option for allogeneic HCT in certain situations, but further research is needed to determine long-term effects and ethical discussions are required to balance the needs of donors and patients when using frozen allografts.", "doi": "10.1038/s41409-023-02099-w", "pmid": "37673982", "labels": {"Type: Review": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41409-023-02099-w"}], "notes": [], "created": "2023-10-06T06:57:23.413Z", "modified": "2023-10-06T11:43:35.176Z"}, {"entity": "publication", "iuid": "46bc6c34a2ab4384b9c54c5e48b65926", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46bc6c34a2ab4384b9c54c5e48b65926.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46bc6c34a2ab4384b9c54c5e48b65926"}}, "title": "The Use of High-Flow Nasal Cannula and Non-Invasive Mechanical Ventilation in the Management of COVID-19 Patients: A Prospective Study.", "authors": [{"family": "Arunachala", "given": "Sumalatha", "initials": "S", "orcid": "0000-0001-5858-8298", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec761000c8c1429ba3459dcd08529abf.json"}}, {"family": "Parthasarathi", "given": "Ashwaghosha", "initials": "A", "orcid": "0000-0002-7270-0247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c0a5e6837a421cbbb0314628ae7f24.json"}}, {"family": "Basavaraj", "given": "Chetak Kadabasal", "initials": "CK", "orcid": "0000-0002-7422-8353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dea3044d43fb4b648b46945d7cb39367.json"}}, {"family": "Malamardi", "given": "Sowmya", "initials": "S"}, {"family": "Chandran", "given": "Shreya", "initials": "S"}, {"family": "Venkataraman", "given": "Hariharan", "initials": "H"}, {"family": "Ullah", "given": "Mohammed Kaleem", "initials": "MK", "orcid": "0000-0001-8470-3114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1645033dc8e84aa493a444301f0403ad.json"}}, {"family": "Ganguly", "given": "Koustav", "initials": "K", "orcid": "0000-0001-8531-8154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58b2e0d7853a4b32920e54042e95061d.json"}}, {"family": "Upadhyay", "given": "Swapna", "initials": "S", "orcid": "0000-0003-4699-4082", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c98621d4161241dd9379dca3fa6e1bf1.json"}}, {"family": "Mahesh", "given": "Padukudru Anand", "initials": "PA", "orcid": "0000-0003-1632-5945", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70c3b10ccc334c4c8195556f07c862d0.json"}}], "type": "journal article", "published": "2023-09-05", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "15", "issue": "9", "issn-l": "1999-4915"}, "abstract": "High-flow nasal cannula (HFNC) and ventilator-delivered non-invasive mechanical ventilation (NIV) were used to treat acute respiratory distress syndrome (ARDS) due to COVID-19 pneumonia, especially in low- and middle-income countries (LMICs), due to lack of ventilators and manpower resources despite the paucity of data regarding their efficacy. This prospective study aimed to analyse the efficacy of HFNC versus NIV in the management of COVID-19 ARDS. A total of 88 RT-PCR-confirmed COVID-19 patients with moderate ARDS were recruited. Linear regression and generalized estimating equations (GEEs) were used for trends in vital parameters over time. A total of 37 patients were on HFNC, and 51 were on NIV. Patients in the HFNC group stayed slightly but not significantly longer in the ICU as compared to their NIV counterparts (HFNC vs. NIV: 8.00 (4.0-12.0) days vs. 7.00 (2.0-12.0) days; p = 0.055). Intubation rates, complications, and mortality were similar in both groups. The switch to HFNC from NIV was 5.8%, while 37.8% required a switch to NIV from HFNC. The resolution of respiratory alkalosis was better with NIV. We conclude that in patients with COVID-19 pneumonia with moderate ARDS, the duration of treatment in the ICU, intubation rate, and mortality did not differ significantly with the use of HFNC or NIV for respiratory support.", "doi": "10.3390/v15091879", "pmid": "37766286", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10535869"}, {"db": "pii", "key": "v15091879"}], "notes": [], "created": "2023-10-06T06:56:33.827Z", "modified": "2023-10-06T06:56:33.999Z"}, {"entity": "publication", "iuid": "db4ad85eac5d4bbe840da6bfb6a0e847", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db4ad85eac5d4bbe840da6bfb6a0e847.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db4ad85eac5d4bbe840da6bfb6a0e847"}}, "title": "Optimal age-specific vaccination control for COVID-19: An Irish case study.", "authors": [{"family": "Zavrakli", "given": "Eleni", "initials": "E", "orcid": "0000-0002-4866-5525", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d1bfa1f3bdd4c7a92e98d2abfe3a7d7.json"}}, {"family": "Parnell", "given": "Andrew", "initials": "A"}, {"family": "Malone", "given": "David", "initials": "D"}, {"family": "Duffy", "given": "Ken", "initials": "K"}, {"family": "Dey", "given": "Subhrakanti", "initials": "S"}], "type": "journal article", "published": "2023-09-05", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "9", "pages": "e0290974"}, "abstract": "The outbreak of a novel coronavirus causing severe acute respiratory syndrome in December 2019 has escalated into a worldwide pandemic. In this work, we propose a compartmental model to describe the dynamics of transmission of infection and use it to obtain the optimal vaccination control. The model accounts for the various stages of the vaccination, and the optimisation is focused on minimising the infections to protect the population and relieve the healthcare system. As a case study, we selected the Republic of Ireland. We use data provided by Ireland's COVID-19 Data-Hub and simulate the evolution of the pandemic with and without the vaccination in place for two different scenarios, one representative of a national lockdown situation and the other indicating looser restrictions in place. One of the main findings of our work is that the optimal approach would involve a vaccination programme where the older population is vaccinated in larger numbers earlier while simultaneously part of the younger population also gets vaccinated to lower the risk of transmission between groups. We compare our simulated results with those of the vaccination policy taken by the Irish government to explore the advantages of our optimisation method. Our comparison suggests that a similar reduction in cases may have been possible even with a reduced set of vaccinations available for use.", "doi": "10.1371/journal.pone.0290974", "pmid": "37669287", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Funder: H2020": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10479919"}, {"db": "pii", "key": "PONE-D-22-29430"}], "notes": [], "created": "2023-10-06T06:57:18.381Z", "modified": "2023-10-09T06:07:48.549Z"}, {"entity": "publication", "iuid": "563c15a9d6e84ace98f3e59d19dc6398", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/563c15a9d6e84ace98f3e59d19dc6398.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/563c15a9d6e84ace98f3e59d19dc6398"}}, "title": "Management of complications after skin surgery relevant for melanoma in the trunk and extremities during the COVID-19 pandemic: a case series report.", "authors": [{"family": "Huang", "given": "Yinglai", "initials": "Y"}, {"family": "Carlsson", "given": "Lena", "initials": "L"}, {"family": "Jogeland", "given": "Karin", "initials": "K"}, {"family": "Samuelsson", "given": "Marianne", "initials": "M"}, {"family": "Larsson", "given": "Lars", "initials": "L"}, {"family": "Jonsborg", "given": "Catarina", "initials": "C"}], "type": "case reports", "published": "2023-09-05", "journal": {"title": "World J Surg Oncol", "issn": "1477-7819", "issn-l": null, "volume": "21", "issue": "1", "pages": "280"}, "abstract": "Patients with melanoma have been found to be at greater risk of adverse outcomes including mortality after contacting COVID-19. Management of postsurgical complications presented additional challenges by potentially increasing exposure to COVID-19 through repeated inpatient admissions to hospital during the pandemic. We report four cases for which skin flaps, lymph ligation, and split-thickness skin graft (STSG) were successfully used in the treatment of complications in the trunk and extremities after wide local excision (WLE). This study details the operative experience in management of postsurgical complications for melanoma in the trunk and extremities during a 6-month period at the height of the COVID-19 pandemic.\r\n\r\nWe present 4 cases detailing management of complications that occurred after wide local excisions performed for melanoma during Feb. to Oct. 2020. Case 1: A 90-year-old man who experienced wound dehiscence and necrosis on the shoulder after non-radical excision for an aggressive melanoma and underwent the side-to-side closure after ellipse formed WLE with modified tangent-to-circle method. Case 2: An 80-year-old man who had undergone excision for melanoma in his left upper arm and histopathology did not show radically. Two weeks after the excision, he underwent a WLE and direct reconstruction with double rotation skin flap. Case 3: A 55-year-old man that experienced a large wound dehiscence on his back due to WLE. He underwent an advanced double skin flap operation. Case 4: A 36-year-old woman who had a lymphorrhea and graft necrosis after WLE and STSG on the right lower leg. A combination of micro lymph ligation and re-STSG was performed. One month after the operation, all wounds had healed. There was no clinical evidence of tumor recurrence after 8 months post procedure.\r\n\r\nSevere complications (e.g., large wound dehiscence, necrosis, or lymphorrhea) following wide local excision of melanoma are infrequent but must be swiftly and appropriately managed, especially during the COVID-19 pandemic to decrease the likelihood of COVID-19 infection and impaired oncology outcomes from delaying systemic cancer therapy due to the complications in primary interventions.", "doi": "10.1186/s12957-023-03084-9", "pmid": "37670317", "labels": {"Category: Health": null, "Category: Other": null, "Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10478401"}, {"db": "pii", "key": "10.1186/s12957-023-03084-9"}], "notes": [], "created": "2023-10-06T06:55:28.836Z", "modified": "2023-10-06T10:54:51.343Z"}, {"entity": "publication", "iuid": "968804a2c4004313b96cfa43ab3c7ea8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/968804a2c4004313b96cfa43ab3c7ea8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/968804a2c4004313b96cfa43ab3c7ea8"}}, "title": "End-of-life decision-making in critically ill old patients with and without coronavirus disease 2019.", "authors": [{"family": "Syrous", "given": "Alma Nordenskj\u00f6ld", "initials": "AN", "orcid": "0000-0002-8599-204X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e76d014cdc440b5ba8dc33aa7583db9.json"}}, {"family": "Gudnadottir", "given": "Gudny", "initials": "G"}, {"family": "Oras", "given": "Jonatan", "initials": "J", "orcid": "0000-0001-8890-6752", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bcac0f5ee544c18ba18e949ce76d121.json"}}, {"family": "Ferguson", "given": "Thalia", "initials": "T"}, {"family": "Lilja", "given": "David", "initials": "D"}, {"family": "Odenstedt Herges", "given": "Helena", "initials": "H", "orcid": "0000-0002-5146-0205", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10c52dc93bee4dd8b6dce4c7b8aa8237.json"}}, {"family": "Larsson", "given": "Emma", "initials": "E"}, {"family": "Block", "given": "Linda", "initials": "L", "orcid": "0000-0002-7736-0093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/829cb3512180455b874595d3f8f42730.json"}}], "type": "journal article", "published": "2023-09-05", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": null, "issue": null, "pages": null}, "abstract": "There are few studies on the differences in end-of-life decisions making in critically ill patients with and without coronavirus disease 2019 (COVID-19). This study aimed to investigate the independent factors that predicted the decision to withdraw or withhold life-sustaining treatments (LST) in critically ill patients and if these decisions were based on different variables for critically ill patients with COVID-19 compared to those for critically ill patients with other diagnoses in a Swedish intensive care unit.\r\n\r\nThis observational pilot study was performed at Sahlgrenska University Hospital, Gothenburg, Sweden. Patients \u226565 years were included from 1 March 2020 to 30 April 2021. The association between a decision to limit LST and a priori selected variables including sex, age, Simplified Acute Physiology Score 3 (SAPS 3), Clinical Frailty Scale \u22654, Charlson Comorbidity Index, Body Mass Index, living at home, invasive and non-invasive mechanical ventilation was assessed using a univariate and multivariable logistic regression model and presented as odds ratio with corresponding 95% confidence intervals.\r\n\r\nThere were 394 patients included in this study, 131 in the non-COVID-19 group and 263 in the COVID-19 group. For the non-COVID-19 cohort, the univariate analysis demonstrated that age and SAPS 3 were significantly associated with the decision to withdraw or withhold life-sustaining treatments, and this association remained in the multivariable analysis, with odds ratios of 1.10 (1.03-1.19) p = .009 and 1.06 (1.03-1.10) p < .001, respectively. For the COVID-19 cohort, the univariate analysis indicated that age, SAPS 3, and Charlson comorbidity index were significantly associated with the decision to withdraw or withhold life-sustaining treatments. However, in multivariable analysis, only the Charlson comorbidity index remained independently associated with the decision to withdraw or withhold life-sustaining treatments, with an odds ratio of 1.26 (1.07-1.49), p = .006.\r\n\r\nDecisions to withdraw or withhold life-sustaining treatments were based on other variables for the critically ill COVID-19 cohort compared to those for the critically ill non-COVID-19 cohort. Further studies are warranted to forge a common path for ethical end-of-life decision-making in critically ill patients.", "doi": "10.1111/aas.14326", "pmid": "37670491", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:55:09.867Z", "modified": "2023-10-06T10:45:20.324Z"}, {"entity": "publication", "iuid": "4ee3d80277934f77933848730ae1f433", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ee3d80277934f77933848730ae1f433.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ee3d80277934f77933848730ae1f433"}}, "title": "Correlates of breakthrough COVID-19 in vaccinated patients with systemic sclerosis: survival analysis from a multicentre international patient-reported survey.", "authors": [{"family": "Ahmed", "given": "Sakir", "initials": "S", "orcid": "0000-0003-4631-311X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd7df1f49c014c33b8ddaae05d8ac052.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Pauling", "given": "John D", "initials": "JD", "orcid": "0000-0002-2793-2364", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e37709273d404d17a88c7c850777b99f.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Ravichandran", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Jagtap", "given": "Kshitij", "initials": "K", "orcid": "0000-0003-2729-737X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822b9da98e5d4eb2975ff97fe484933f.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Saha", "given": "Sreoshy", "initials": "S", "orcid": "0000-0001-6745-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00238845dd4833ae51ffb75e2fe144.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Kardes", "given": "Sinan", "initials": "S", "orcid": "0000-0002-6311-8634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2900c3ca00da476a8914574384a3c9c2.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Wibowo", "given": "Suryo Anggoro Kusumo", "initials": "SAK"}, {"family": "COVAD Study Group", "given": "", "initials": ""}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}], "type": "journal article", "published": "2023-09-05", "journal": {"title": "Rheumatol Int", "issn": "1437-160X", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "This study aimed to assess the incidence, predictors, and outcomes of breakthrough infection (BI) following coronavirus disease (COVID-19) vaccination in patients with systemic sclerosis (SSc), a risk group associated with an immune-suppressed state and high cardiopulmonary disease burden. Cross-sectional data from fully vaccinated respondents with SSc, non-SSc autoimmune rheumatic diseases (AIRDs), and healthy controls (HCs) were extracted from the COVAD database, an international self-reported online survey. BI was defined according to the Centre for Disease Control definition. Infection-free survival was compared between the groups using Kaplan-Meier curves with log-rank tests. Cox proportional regression was used to assess the association between BI and age, sex, ethnicity, and immunosuppressive drugs at the time of vaccination. The severity of BI in terms of hospitalization and requirement for oxygen supplementation was compared between groups. Of 10,900 respondents, 6836 fulfilled the following inclusion criteria: 427 SSc, 2934 other AIRDs, and 3475 HCs. BI were reported in 6.3% of SSc, 6.9% of non-SSc AIRD, and 16.1% of HCs during a median follow-up of 100 (IQR: 60-137) days. SSc had a lower risk for BI than HC [hazard ratio (HR): 0.56 (95% CI 0.46-0.74)]. BIs were associated with age [HR: 0.98 (0.97-0.98)] but not ethnicity or immunosuppressive drugs at the time of vaccination. Patients with SSc were more likely to have asymptomatic COVID-19, but symptomatic patients reported more breathlessness. Hospitalization [SSc: 4 (14.8%), HCs: 37 (6.6%), non-SSc AIRDs: 32(15.8%)] and the need for oxygenation [SSc: 1 (25%); HC: 17 (45.9%); non-SSc AIRD: 13 (40.6%)] were similar between the groups. The incidence of BI in SSc was lower than that in HCs but comparable to that in non-SSc AIRDs. The severity of BI did not differ between the groups. Advancing age, but not ethnicity or immunosuppressive medication use, was associated with BIs.", "doi": "10.1007/s00296-023-05433-z", "pmid": "37668836", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00296-023-05433-z"}], "notes": [], "created": "2023-10-06T06:57:20.805Z", "modified": "2023-10-06T11:42:16.083Z"}, {"entity": "publication", "iuid": "7169dbc16bc04befabcac692ecef94df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7169dbc16bc04befabcac692ecef94df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7169dbc16bc04befabcac692ecef94df"}}, "title": "Post COVID-19 condition after SARS-CoV-2 infections during the omicron surge compared with the delta, alpha, and wild-type periods in Stockholm, Sweden.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P", "orcid": "0000-0003-3153-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd6af5accfc84ff9a81983a5ab6683aa.json"}}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2023-09-04", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899", "volume": null, "issue": null, "pages": null}, "abstract": "Little is known about post COVID-19 condition (PCC) after infections with different SARS-CoV-2 variants. We investigated the risk of PCC diagnosis after primary omicron infections compared with preceding variants in population-based cohorts in Stockholm, Sweden. Compared to omicron (n=215,279, 0.2% receiving a PCC diagnosis), the adjusted hazard ratio (95% confidence interval) was 3.26 (2.80 to 3.80) for delta (n=52,182, 0.5% PCC diagnosis), 5.33 (4.73 to 5.99) for alpha (n=97,978, 1.0% PCC diagnosis), and 6.31 (5.64 to 7.06) for wild-type (n=107,920, 1.3% PCC diagnosis). These findings were consistent across all subgroup analyses except among the ICU-treated.", "doi": "10.1093/infdis/jiad382", "pmid": "37665981", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Post-COVID": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "7259851"}], "notes": [], "created": "2023-10-06T06:52:43.737Z", "modified": "2023-10-06T09:54:10.819Z"}, {"entity": "publication", "iuid": "8452f5efb4e6418a9fef297f94232fce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8452f5efb4e6418a9fef297f94232fce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8452f5efb4e6418a9fef297f94232fce"}}, "title": "Oligomeric State of \u03b2-Coronavirus Non-Structural Protein 10 Stimulators Studied by Small Angle X-ray Scattering.", "authors": [{"family": "Knecht", "given": "Wolfgang", "initials": "W"}, {"family": "Fisher", "given": "S Zo\u00eb", "initials": "SZ"}, {"family": "Lou", "given": "Jiaqi", "initials": "J"}, {"family": "Sele", "given": "C\u00e9leste", "initials": "C"}, {"family": "Ma", "given": "Shumeng", "initials": "S"}, {"family": "Rasmussen", "given": "Anna Andersson", "initials": "AA"}, {"family": "Pinotsis", "given": "Nikos", "initials": "N"}, {"family": "Kozielski", "given": "Frank", "initials": "F", "orcid": "0000-0001-6096-9102", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8544f97e0f8841729c41626e742ec75f.json"}}], "type": "journal article", "published": "2023-09-04", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "issn-l": null, "volume": "24", "issue": "17", "pages": null}, "abstract": "The \u03b2-coronavirus family, encompassing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Severe Acute Respiratory Syndrome Coronavirus (SARS), and Middle East Respiratory Syndrome Coronavirus (MERS), has triggered pandemics within the last two decades. With the possibility of future pandemics, studying the coronavirus family members is necessary to improve knowledge and treatment. These viruses possess 16 non-structural proteins, many of which play crucial roles in viral replication and in other vital functions. One such vital protein is non-structural protein 10 (nsp10), acting as a pivotal stimulator of nsp14 and nsp16, thereby influencing RNA proofreading and viral RNA cap formation. Studying nsp10 of pathogenic coronaviruses is central to unraveling its multifunctional roles. Our study involves the biochemical and biophysical characterisation of full-length nsp10 from MERS, SARS and SARS-CoV-2. To elucidate their oligomeric state, we employed a combination of Multi-detection Size exclusion chromatography (Multi-detection SEC) with multi-angle static light scattering (MALS) and small angle X-ray scattering (SAXS) techniques. Our findings reveal that full-length nsp10s primarily exist as monomers in solution, while truncated versions tend to oligomerise. SAXS experiments reveal a globular shape for nsp10, a trait conserved in all three coronaviruses, although MERS nsp10, diverges most from SARS and SARS-CoV-2 nsp10s. In summary, unbound nsp10 proteins from SARS, MERS, and SARS-CoV-2 exhibit a globular and predominantly monomeric state in solution.", "doi": "10.3390/ijms241713649", "pmid": "37686452", "labels": {"Type: Journal article": null, "Category: Proteins": null, "Category: Imaging": null}, "xrefs": [{"db": "pii", "key": "ijms241713649"}], "notes": [], "created": "2023-10-06T06:57:03.206Z", "modified": "2023-10-06T11:34:06.712Z"}, {"entity": "publication", "iuid": "862c7810ef7a48d7b6334953b87bc98c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/862c7810ef7a48d7b6334953b87bc98c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/862c7810ef7a48d7b6334953b87bc98c"}}, "title": "Reducing intrusive memories after trauma via an imagery-competing task intervention in COVID-19 intensive care staff: a randomised controlled trial.", "authors": [{"family": "Iyadurai", "given": "Lalitha", "initials": "L"}, {"family": "Highfield", "given": "Julie", "initials": "J"}, {"family": "Kanstrup", "given": "Marie", "initials": "M", "orcid": "0000-0003-2060-5288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86830095163d4e14b62d78e8ed149b2e.json"}}, {"family": "Markham", "given": "Alfred", "initials": "A"}, {"family": "Ramineni", "given": "Varsha", "initials": "V", "orcid": "0000-0002-0330-3184", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9d359662cf044ac8308614e0f62f908.json"}}, {"family": "Guo", "given": "Boliang", "initials": "B"}, {"family": "Jaki", "given": "Thomas", "initials": "T"}, {"family": "Kingslake", "given": "Jonathan", "initials": "J", "orcid": "0000-0003-1741-1802", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d55190abd6f5468f8cb4f1890b0744fc.json"}}, {"family": "Goodwin", "given": "Guy M", "initials": "GM"}, {"family": "Summers", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-7269-2873", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd46e0acccc1403eae9148a5273f1a71.json"}}, {"family": "Bonsall", "given": "Michael B", "initials": "MB", "orcid": "0000-0003-0250-0423", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf8ee242158a4422ab7f8c00fb827150.json"}}, {"family": "Holmes", "given": "Emily A", "initials": "EA", "orcid": "0000-0001-7319-3112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be06518242494a02bd7cb6cf60a67541.json"}}], "type": "randomized controlled trial", "published": "2023-09-01", "journal": {"title": "Transl Psychiatry", "issn": "2158-3188", "issn-l": null, "volume": "13", "issue": "1", "pages": "290"}, "abstract": "Intrusive memories (IMs) after traumatic events can be distressing and disrupt mental health and functioning. We evaluated the impact of a brief remotely-delivered digital imagery-competing task intervention on the number of IMs for intensive care unit (ICU) staff who faced repeated trauma exposure during the COVID-19 pandemic using a two-arm, parallel-group, single-blind randomised controlled trial, with the comparator arm receiving delayed access to active treatment (crossover). Eligible participants worked clinically in a UK NHS ICU during the pandemic and had at least 3 IMs of work-related traumatic events in the week before recruitment. Participants were randomly assigned (1:1) to immediate (weeks 1-4) or delayed (weeks 5-8) intervention access. Sequential Bayesian analyses to optimise the intervention and increase trial efficiency are reported elsewhere [1]. The primary endpoint for the pre-specified frequentist analysis of the final study population compared the number of IMs experienced in week 4 between the immediate and delayed access arms. Secondary outcomes included clinical symptoms, work functioning and wellbeing. Safety was assessed throughout the trial by scheduled questions and free report. All analyses were undertaken on an intention-to-treat basis (86 randomised participants). There were significantly fewer intrusive memories during week 4 in the immediate (median = 1, IQR = 0-3, n = 43), compared to the comparator delayed arm (median = 10, IQR = 6-17, n = 43), IRR 0.31, 95% CI: 0.20-0.48, p < 0.001. After crossover, the delayed arm also showed a significant reduction in IMs at week 8 compared to week 4. There were convergent findings for symptoms of PTSD, insomnia and anxiety, work engagement and burnout, general functioning and quality of life. The intervention was found safe and acceptable to participants. All adverse events were unrelated to the study. Our study provides the first evidence of a benefit on reducing IMs, improving other clinical symptoms, work functioning and wellbeing, as well as safety of a brief remotely-delivered digital imagery-competing task intervention. An efficacy trial with an active control and longer follow-up is warranted. The trial is registered at ClinicalTrials.gov (NCT04992390).", "doi": "10.1038/s41398-023-02578-0", "pmid": "37658043", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10474101"}, {"db": "pii", "key": "10.1038/s41398-023-02578-0"}, {"db": "ClinicalTrials.gov", "key": "NCT04992390"}], "notes": [], "created": "2023-10-06T06:57:39.451Z", "modified": "2023-10-06T11:46:28.613Z"}, {"entity": "publication", "iuid": "8d698dc394ec4e62b585236343b3bc0f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d698dc394ec4e62b585236343b3bc0f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d698dc394ec4e62b585236343b3bc0f"}}, "title": "Radiological appearance and lung function six months after invasive ventilation in ICU for COVID-19 pneumonia: An observational follow-up study.", "authors": [{"family": "Konsberg", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-1542-5402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24e0c2f7ceaa45958a0a059f4e4f322d.json"}}, {"family": "Szaro", "given": "Pawel", "initials": "P"}, {"family": "Aneman", "given": "Anders", "initials": "A"}, {"family": "Kjellberg", "given": "Sanna", "initials": "S"}, {"family": "Solidakis", "given": "Nektarios", "initials": "N"}, {"family": "Svedlund", "given": "Sara", "initials": "S"}, {"family": "Nellg\u00e5rd", "given": "Bengt", "initials": "B"}, {"family": "Dalla", "given": "Keti", "initials": "K", "orcid": "0000-0001-7367-2500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f1c43bc04bf49a7adc3559aa5deb916.json"}}], "type": "observational study", "published": "2023-09-01", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "9", "pages": "e0289603"}, "abstract": "Respiratory functional sequelae in COVID-19 patients admitted to the intensive care unit for invasive ventilation are sparsely reported. The aim of this study was to investigate the radiological lung appearance, lung function and their association at 6 months after hospital discharge. It was hypothesized that the degree of pathological morphology on CT scans would correlate with lung function at the time of follow-up.\r\n\r\nIn this single-centre prospective observational study, 86 from 154 patients admitted to ICU due to COVID-19 between March 2020 and May 2021 were followed up at 6 months post discharge with computed tomography (CT) of the chest and pulmonary function tests (PFTs). The PFT results were expressed as z-scores calculated as the difference between the measured and predicted values divided by the standard deviation obtained from a reference population. Correlations were evaluated by Spearman's rho including the 95% confidence interval. Pathological changes on CT were found in 78/85 participants with fibrous parenchymal bands being the most prevalent finding (91%) followed by traction bronchiectasis (64%) and ground glass opacities (41%). Sixty-five participants performed PFTs, and a restrictive pattern was the most prevalent abnormality (34%). Diffusing capacity of the lung for carbon monoxide (DLCO) was reduced in 66% of participants. The CT severity score weakly correlated with forced vital capacity (FVC) z-score (0.295, p = 0.006), DLCO z-score (-0.231, p = 0.032) and alveolar volume (VA) z-score (0.253, p = 0.019).\r\n\r\nMost patients showed persistent radiological abnormalities on CT and reduced lung volumes, impaired diffusion capacity and patterns of restrictive lung function at 6 months post discharge from the ICU. The correlations between abnormalities on CT and lung function tests were weak. Further, studies with a long-term follow-up of lung function in this group of patients are needed.", "doi": "10.1371/journal.pone.0289603", "pmid": "37656699", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Imaging": null}, "xrefs": [{"db": "pmc", "key": "PMC10473523"}, {"db": "pii", "key": "PONE-D-22-31787"}], "notes": [], "created": "2023-10-06T06:57:08.003Z", "modified": "2023-10-06T11:37:14.743Z"}, {"entity": "publication", "iuid": "0fffeafdba3d43eaae8050e352b1b921", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0fffeafdba3d43eaae8050e352b1b921.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0fffeafdba3d43eaae8050e352b1b921"}}, "title": "Pentameric C-reactive protein is a better prognostic biomarker and remains elevated for longer than monomeric CRP in hospitalized patients with COVID-19.", "authors": [{"family": "Hopkins", "given": "Francis R", "initials": "FR"}, {"family": "Nordgren", "given": "Johan", "initials": "J"}, {"family": "Fernandez-Botran", "given": "Rafael", "initials": "R"}, {"family": "Enocsson", "given": "Helena", "initials": "H"}, {"family": "Govender", "given": "Melissa", "initials": "M"}, {"family": "Svanberg", "given": "Cecilia", "initials": "C"}, {"family": "Svensson", "given": "Lennart", "initials": "L"}, {"family": "Hagbom", "given": "Marie", "initials": "M"}, {"family": "Nilsdotter-Augustinsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Nystr\u00f6m", "given": "Sofia", "initials": "S"}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C"}, {"family": "Sj\u00f6wall", "given": "Johanna", "initials": "J"}, {"family": "Larsson", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2023-09-01", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "1259005"}, "abstract": "The differing roles of the pentameric (p) and monomeric (m) C-reactive protein (CRP) isoforms in viral diseases are not fully understood, which was apparent during the COVID-19 pandemic regarding the clinical course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Herein, we investigated the predictive value of the pCRP and mCRP isoforms for COVID-19 severity in hospitalized patients and evaluated how the levels of the protein isoforms changed over time during and after acute illness. This study utilized samples from a well-characterized cohort of Swedish patients with SARS-CoV-2 infection, the majority of whom had known risk factors for severe COVID-19 and required hospitalization. The levels of pCRP were significantly raised in patients with severe COVID-19 and in contrast to mCRP the levels were significantly associated with disease severity. Additionally, the pCRP levels remained elevated for at least six weeks post inclusion, which was longer compared to the two weeks for mCRP. Our data indicates a low level of inflammation lasting for at least six weeks following COVID-19, which might indicate that the disease has an adverse effect on the immune system even after the viral infection is resolved. It is also clear that the current standard method of testing pCRP levels upon hospitalization is a useful marker for predicting disease severity and mCRP testing would not add any clinical relevance for patients with COVID-19.", "doi": "10.3389/fimmu.2023.1259005", "pmid": "37724104", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Proteins": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10505432"}], "notes": [], "created": "2023-10-06T06:52:15.856Z", "modified": "2023-10-06T08:29:02.801Z"}, {"entity": "publication", "iuid": "d953102b4ac049d68c80a689db691673", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d953102b4ac049d68c80a689db691673.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d953102b4ac049d68c80a689db691673"}}, "title": "Occupational risks associated with severe COVID-19 disease and SARS-CoV-2 infection - a Swedish national case-control study conducted from October 2020 to December 2021.", "authors": [{"family": "Tor\u00e9n", "given": "Kjell", "initials": "K"}, {"family": "Albin", "given": "Maria", "initials": "M"}, {"family": "Bergstr\u00f6m", "given": "Tomas", "initials": "T"}, {"family": "Murgia", "given": "Nicola", "initials": "N"}, {"family": "Alderling", "given": "Magnus", "initials": "M"}, {"family": "Schi\u00f6ler", "given": "Linus", "initials": "L"}, {"family": "\u00c5berg", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2023-09-01", "journal": {"title": "Scand J Work Environ Health", "issn": "1795-990X", "issn-l": null, "volume": "49", "issue": "6", "pages": "386-394"}, "abstract": "This study aimed to investigate whether workplace factors and occupations are associated with SARS-CoV-2 infection or severe COVID-19 in the later waves of the pandemic.\r\n\r\nWe studied 552 562 cases with a positive test for SARS-CoV-2 in the Swedish registry of communicable diseases, and 5985 cases with severe COVID-19 based on hospital admissions from October 2020 to December 2021. Four population controls were assigned the index dates of their corresponding cases. We linked job histories to job-exposure matrices to assess the odds for different transmission dimensions and different occupations. We used adjusted conditional logistic analyses to estimate odds ratios (OR) for severe COVID-19 and SARS-CoV-2 with 95% confidence intervals (CI).\r\n\r\nThe highest OR for severe COVID-19 were for: regular contact with infected patients, (OR 1.37, 95% CI 1.23-1.54), close physical proximity (OR 1.47, 95% CI 1.34-1.61), and high exposure to diseases or infections (OR 1.72, 95% CI 1.52-1.96). Mostly working outside had lower OR (OR 0.77, 95% CI 0.57-1.06). The odds for SARS-CoV-2 when mostly working outside were similar (OR 0.83, 95% CI 0.80-0.86). The occupation with the highest OR for severe COVID-19 (compared with low-exposure occupations) was certified specialist physician (OR 2.05, 95% CI 1.31-3.21) among women and bus and tram drivers (OR 2.04, 95% CI 1.49-2.79) among men.\r\n\r\nContact with infected patients, close proximity and crowded workplaces increase the risks for severe COVID-19 and SARS-CoV-2 infection. Outdoor work is associated with decreased odds for SARS-CoV-2 infection and severe COVID-19.", "doi": "10.5271/sjweh.4103", "pmid": "37417898", "labels": {"Type: Journal article": null, "Funder: Forte": null, "Category: Other": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "4103"}], "notes": [], "created": "2023-10-04T12:07:32.911Z", "modified": "2023-10-04T12:16:58.601Z"}, {"entity": "publication", "iuid": "6cc1aecaf6a34214b4f33d84c367e7c2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6cc1aecaf6a34214b4f33d84c367e7c2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6cc1aecaf6a34214b4f33d84c367e7c2"}}, "title": "Trends in invasive bacterial diseases during the first 2 years of the COVID-19 pandemic: analyses of prospective surveillance data from 30 countries and territories in the IRIS Consortium.", "authors": [{"family": "Shaw", "given": "David", "initials": "D"}, {"family": "Abad", "given": "Raquel", "initials": "R"}, {"family": "Amin-Chowdhury", "given": "Zahin", "initials": "Z"}, {"family": "Bautista", "given": "Adriana", "initials": "A"}, {"family": "Bennett", "given": "Desiree", "initials": "D"}, {"family": "Broughton", "given": "Karen", "initials": "K"}, {"family": "Cao", "given": "Bin", "initials": "B"}, {"family": "Casanova", "given": "Carlo", "initials": "C"}, {"family": "Choi", "given": "Eun Hwa", "initials": "EH"}, {"family": "Chu", "given": "Yiu-Wai", "initials": "Y"}, {"family": "Claus", "given": "Heike", "initials": "H"}, {"family": "Coelho", "given": "Juliana", "initials": "J"}, {"family": "Corcoran", "given": "Mary", "initials": "M"}, {"family": "Cottrell", "given": "Simon", "initials": "S"}, {"family": "Cunney", "given": "Robert", "initials": "R"}, {"family": "Cuypers", "given": "Lize", "initials": "L"}, {"family": "Dalby", "given": "Tine", "initials": "T"}, {"family": "Davies", "given": "Heather", "initials": "H"}, {"family": "de Gouveia", "given": "Linda", "initials": "L"}, {"family": "Deghmane", "given": "Ala-Eddine", "initials": "A"}, {"family": "Demczuk", "given": "Walter", "initials": "W"}, {"family": "Desmet", "given": "Stefanie", "initials": "S"}, {"family": "Domenech", "given": "Mirian", "initials": "M"}, {"family": "Drew", "given": "Richard", "initials": "R"}, {"family": "du Plessis", "given": "Mignon", "initials": "M"}, {"family": "Duarte", "given": "Carolina", "initials": "C"}, {"family": "Erlendsd\u00f3ttir", "given": "Helga", "initials": "H"}, {"family": "Fry", "given": "Norman K", "initials": "NK"}, {"family": "Fuursted", "given": "Kurt", "initials": "K"}, {"family": "Hale", "given": "Thomas", "initials": "T"}, {"family": "Henares", "given": "Desiree", "initials": "D"}, {"family": "Henriques-Normark", "given": "Birgitta", "initials": "B"}, {"family": "Hilty", "given": "Markus", "initials": "M"}, {"family": "Hoffmann", "given": "Steen", "initials": "S"}, {"family": "Humphreys", "given": "Hilary", "initials": "H"}, {"family": "Ip", "given": "Margaret", "initials": "M"}, {"family": "Jacobsson", "given": "Susanne", "initials": "S"}, {"family": "Johnson", "given": "Christopher", "initials": "C"}, {"family": "Johnston", "given": "Jillian", "initials": "J"}, {"family": "Jolley", "given": "Keith A", "initials": "KA"}, {"family": "Kawabata", "given": "An\u00edbal", "initials": "A"}, {"family": "Kozakova", "given": "Jana", "initials": "J"}, {"family": "Kristinsson", "given": "Karl G", "initials": "KG"}, {"family": "Krizova", "given": "Pavla", "initials": "P"}, {"family": "Kuch", "given": "Alicja", "initials": "A"}, {"family": "Ladhani", "given": "Shamez", "initials": "S"}, {"family": "L\u00e2m", "given": "Thi\u00ean-Tr\u00ed", "initials": "T"}, {"family": "Le\u00f3n", "given": "Mar\u00eda Eugenia", "initials": "ME"}, {"family": "Lindholm", "given": "Laura", "initials": "L"}, {"family": "Litt", "given": "David", "initials": "D"}, {"family": "Maiden", "given": "Martin C J", "initials": "MCJ"}, {"family": "Martin", "given": "Irene", "initials": "I"}, {"family": "Martiny", "given": "Delphine", "initials": "D"}, {"family": "Mattheus", "given": "Wesley", "initials": "W"}, {"family": "McCarthy", "given": "Noel D", "initials": "ND"}, {"family": "Meehan", "given": "Mary", "initials": "M"}, {"family": "Meiring", "given": "Susan", "initials": "S"}, {"family": "M\u00f6lling", "given": "Paula", "initials": "P"}, {"family": "Morfeldt", "given": "Eva", "initials": "E"}, {"family": "Morgan", "given": "Julie", "initials": "J"}, {"family": "Mulhall", "given": "Robert", "initials": "R"}, {"family": "Mu\u00f1oz-Almagro", "given": "Carmen", "initials": "C"}, {"family": "Murdoch", "given": "David", "initials": "D"}, {"family": "Murphy", "given": "Joy", "initials": "J"}, {"family": "Musilek", "given": "Martin", "initials": "M"}, {"family": "Mzabi", "given": "Alexandre", "initials": "A"}, {"family": "Novakova", "given": "Ludmila", "initials": "L"}, {"family": "Oftadeh", "given": "Shahin", "initials": "S"}, {"family": "Perez-Arg\u00fcello", "given": "Amaresh", "initials": "A"}, {"family": "P\u00e9rez-V\u00e1zquez", "given": "Maria", "initials": "M"}, {"family": "Perrin", "given": "Monique", "initials": "M"}, {"family": "Perry", "given": "Malorie", "initials": "M"}, {"family": "Prevost", "given": "Benoit", "initials": "B"}, {"family": "Roberts", "given": "Maria", "initials": "M"}, {"family": "Rokney", "given": "Assaf", "initials": "A"}, {"family": "Ron", "given": "Merav", "initials": "M"}, {"family": "Sanabria", "given": "Olga Marina", "initials": "OM"}, {"family": "Scott", "given": "Kevin J", "initials": "KJ"}, {"family": "Sheppard", "given": "Carmen", "initials": "C"}, {"family": "Siira", "given": "Lotta", "initials": "L"}, {"family": "Sintchenko", "given": "Vitali", "initials": "V"}, {"family": "Skoczy\u0144ska", "given": "Anna", "initials": "A"}, {"family": "Sloan", "given": "Monica", "initials": "M"}, {"family": "Slotved", "given": "Hans-Christian", "initials": "H"}, {"family": "Smith", "given": "Andrew J", "initials": "AJ"}, {"family": "Steens", "given": "Anneke", "initials": "A"}, {"family": "Taha", "given": "Muhamed-Kheir", "initials": "M"}, {"family": "Toropainen", "given": "Maija", "initials": "M"}, {"family": "Tzanakaki", "given": "Georgina", "initials": "G"}, {"family": "Vainio", "given": "Anni", "initials": "A"}, {"family": "van der Linden", "given": "Mark P G", "initials": "MPG"}, {"family": "van Sorge", "given": "Nina M", "initials": "NM"}, {"family": "Varon", "given": "Emmanuelle", "initials": "E"}, {"family": "Vohrnova", "given": "Sandra", "initials": "S"}, {"family": "von Gottberg", "given": "Anne", "initials": "A"}, {"family": "Yuste", "given": "Jose", "initials": "J"}, {"family": "Zanella", "given": "Rosemeire", "initials": "R"}, {"family": "Zhou", "given": "Fei", "initials": "F"}, {"family": "Brueggemann", "given": "Angela B", "initials": "AB"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "The Lancet Digital Health", "issn": "2589-7500", "issn-l": null, "volume": "5", "issue": "9", "pages": "e582-e593"}, "abstract": "The Invasive Respiratory Infection Surveillance (IRIS) Consortium was established to assess the impact of the COVID-19 pandemic on invasive diseases caused by Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, and Streptococcus agalactiae. We aimed to analyse the incidence and distribution of these diseases during the first 2 years of the COVID-19 pandemic compared to the 2 years preceding the pandemic.\r\n\r\nFor this prospective analysis, laboratories in 30 countries and territories representing five continents submitted surveillance data from Jan 1, 2018, to Jan 2, 2022, to private projects within databases in PubMLST. The impact of COVID-19 containment measures on the overall number of cases was analysed, and changes in disease distributions by patient age and serotype or group were examined. Interrupted time-series analyses were done to quantify the impact of pandemic response measures and their relaxation on disease rates, and autoregressive integrated moving average models were used to estimate effect sizes and forecast counterfactual trends by hemisphere.\r\n\r\nOverall, 116 841 cases were analysed: 76 481 in 2018-19, before the pandemic, and 40 360 in 2020-21, during the pandemic. During the pandemic there was a significant reduction in the risk of disease caused by S pneumoniae (risk ratio 0\u00b747; 95% CI 0\u00b740-0\u00b755), H influenzae (0\u00b751; 0\u00b740-0\u00b766) and N meningitidis (0\u00b726; 0\u00b721-0\u00b731), while no significant changes were observed for S agalactiae (1\u00b702; 0\u00b775-1\u00b740), which is not transmitted via the respiratory route. No major changes in the distribution of cases were observed when stratified by patient age or serotype or group. An estimated 36 289 (95% prediction interval 17 145-55 434) cases of invasive bacterial disease were averted during the first 2 years of the pandemic among IRIS-participating countries and territories.\r\n\r\nCOVID-19 containment measures were associated with a sustained decrease in the incidence of invasive disease caused by S pneumoniae, H influenzae, and N meningitidis during the first 2 years of the pandemic, but cases began to increase in some countries towards the end of 2021 as pandemic restrictions were lifted. These IRIS data provide a better understanding of microbial transmission, will inform vaccine development and implementation, and can contribute to health-care service planning and provision of policies.\r\n\r\nWellcome Trust, NIHR Oxford Biomedical Research Centre, Spanish Ministry of Science and Innovation, Korea Disease Control and Prevention Agency, Torsten S\u00f6derberg Foundation, Stockholm County Council, Swedish Research Council, German Federal Ministry of Health, Robert Koch Institute, Pfizer, Merck, and the Greek National Public Health Organization.", "doi": "10.1016/S2589-7500(23)00108-5", "pmid": "37516557", "labels": {"Funder: VR": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2589-7500(23)00108-5"}], "notes": [], "created": "2023-10-04T12:10:31.535Z", "modified": "2023-10-04T13:15:07.482Z"}, {"entity": "publication", "iuid": "3b387324ed684abbae797117ddd0f81d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b387324ed684abbae797117ddd0f81d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b387324ed684abbae797117ddd0f81d"}}, "title": "The impact of the COVID-19 pandemic on children's learning and wellbeing: Evidence from India.", "authors": [{"family": "Guariso", "given": "Andrea", "initials": "A"}, {"family": "Bj\u00f6rkman Nyqvist", "given": "Martina", "initials": "M"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "J Dev Econ", "issn": "0304-3878", "issn-l": null, "volume": "164", "issue": null, "pages": "103133"}, "abstract": "We study the impact of the COVID-19 pandemic and associated school closure on primary school children's learning and mental wellbeing in Assam, India. Using a comprehensive dataset that tracked and repeatedly surveyed approximately 5000 children across 200 schools between 2018 and 2022, we find that children lost the equivalent of nine months of learning in mathematics and eleven months in language, during the pandemic. Children lacking resources and parental support experienced the largest losses. Regular practice, teacher interaction, and technology were associated with less learning loss. Over the same period, children's psychological wellbeing improved. Our research provides valuable insights for designing post-emergency programs.", "doi": "10.1016/j.jdeveco.2023.103133", "pmid": "37342545", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10264163"}, {"db": "pii", "key": "S0304-3878(23)00088-3"}], "notes": [], "created": "2023-10-04T09:32:19.037Z", "modified": "2023-10-04T11:01:58.570Z"}, {"entity": "publication", "iuid": "1c7f7c858ead4b93b04d424ae469e1fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1c7f7c858ead4b93b04d424ae469e1fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1c7f7c858ead4b93b04d424ae469e1fc"}}, "title": "Seasonal influence on respiratory tract infection severity including COVID-19 quantified through Markov Chain modeling.", "authors": [{"family": "van Wijk", "given": "Rob C", "initials": "RC", "orcid": "0000-0001-7247-1360", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aac8bd1a2d674d6c891c1a0becf997d8.json"}}, {"family": "Mockeliunas", "given": "Laurynas", "initials": "L", "orcid": "0000-0002-7008-4946", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f6959d9dd1f42a1abdd09bdf8d739f3.json"}}, {"family": "Upton", "given": "Caryn M", "initials": "CM"}, {"family": "Peter", "given": "Jonathan", "initials": "J"}, {"family": "Diacon", "given": "Andreas H", "initials": "AH"}, {"family": "Simonsson", "given": "Ulrika S H", "initials": "USH", "orcid": "0000-0002-3424-9686", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf510f552f2846b5bbb7740872a7c24a.json"}}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "CPT Pharmacometrics Syst. Pharmacol.", "issn": "2163-8306", "issn-l": null, "volume": "12", "issue": "9", "pages": "1250-1261"}, "abstract": "Respiratory tract infections (RTIs) are a burden to global health, but their characterization is complicated by the influence of seasonality on incidence and severity. The Re-BCG-CoV-19 trial (NCT04379336) assessed BCG (re)vaccination for protection from coronavirus disease 2019 (COVID-19) and recorded 958 RTIs in 574 individuals followed over 1 year. We characterized the probability of RTI occurrence and severity using a Markov model with health scores (HSs) for four states of symptom severity. Covariate analysis on the transition probability between HSs explored the influence of demographics, medical history, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), or influenza vaccinations, which became available during the trial, SARS-CoV-2 serology, and epidemiology-informed seasonal influence of infection pressure represented as regional COVID-19 pandemic waves, as well as BCG (re)vaccination. The infection pressure reflecting the pandemic waves increased the risk of RTI symptom development, whereas the presence of SARS-CoV-2 antibodies protected against RTI symptom development and increased the probability of symptom relief. Higher probability of symptom relief was also found in participants with African ethnicity and with male biological gender. SARS-CoV-2 or influenza vaccination reduced the probability of transitioning from mild to healthy symptoms. Model diagnostics over calendar-time indicated that COVID-19 cases were under-reported during the first wave by an estimated 2.76-fold. This trial was performed during the initial phase of the COVID-19 pandemic in South Africa and the results reflect that situation. Using this unique clinical dataset of prospectively studied RTIs over the course of 1 year, our Markov Chain model was able to capture risk factors for RTI development and severity, including epidemiology-informed infection pressure.", "doi": "10.1002/psp4.13006", "pmid": "37401774", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10508522"}, {"db": "ClinicalTrials.gov", "key": "NCT04379336"}], "notes": [], "created": "2023-10-04T12:07:40.665Z", "modified": "2023-10-04T12:22:15.271Z"}, {"entity": "publication", "iuid": "ed5ee9e208d34b9283c8973da3e782a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed5ee9e208d34b9283c8973da3e782a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed5ee9e208d34b9283c8973da3e782a1"}}, "title": "Operational challenges and mitigation measures during the COVID-19 pandemic-Lessons from DELIVER.", "authors": [{"family": "Bhatt", "given": "Ankeet S", "initials": "AS"}, {"family": "Lindholm", "given": "Daniel", "initials": "D"}, {"family": "Nilsson", "given": "Ann", "initials": "A"}, {"family": "Zaozerska", "given": "Natalia", "initials": "N"}, {"family": "Claggett", "given": "Brian L", "initials": "BL"}, {"family": "Vaduganathan", "given": "Muthiah", "initials": "M"}, {"family": "Kosiborod", "given": "Mikhail N", "initials": "MN"}, {"family": "Lam", "given": "Carolyn S P", "initials": "CSP"}, {"family": "Hernandez", "given": "Adrian F", "initials": "AF"}, {"family": "Martinez", "given": "Felipe A", "initials": "FA"}, {"family": "Inzucchi", "given": "Silvio E", "initials": "SE"}, {"family": "Shah", "given": "Sanjiv J", "initials": "SJ"}, {"family": "de Boer", "given": "Rudolf A", "initials": "RA"}, {"family": "Desai", "given": "Akshay", "initials": "A"}, {"family": "Jhund", "given": "Pardeep S", "initials": "PS"}, {"family": "Langkilde", "given": "Anna Maria", "initials": "AM"}, {"family": "Petersson", "given": "Magnus", "initials": "M"}, {"family": "McMurray", "given": "John J V", "initials": "JJV"}, {"family": "Solomon", "given": "Scott D", "initials": "SD"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Am Heart J", "issn": "1097-6744", "issn-l": null, "volume": "263", "issue": null, "pages": "133-140"}, "abstract": "Catastrophic disruptions in care delivery threaten the operational efficiency and potentially the validity of clinical research efforts, in particular randomized clinical trials. Most recently, the COVID-19 pandemic affected essentially all aspects of care delivery and clinical research conduct. While consensus statements and clinical guidance documents have detailed potential mitigation measures, few real-world experiences detailing clinical trial adaptations to the COVID-19 pandemic exist, particularly among, large, global registrational cardiovascular trials.\r\n\r\nWe outline the operational impact of COVID-19 and resultant mitigation measures in the Dapagliflozin Evaluation to Improve the LIVEs of Patients with Preserved Ejection Fraction Heart Failure (DELIVER) trial, one of the largest and most globally diverse experiences with COVID-19 of any cardiovascular clinical trial to date. Specifically, we address the needed coordination between academic investigators, trial leadership, clinical sites, and the supporting sponsor to ensure the safety of participants and trial staff, to maintain the fidelity of trial operations, and to prospectively adapt statistical analyses plans to evaluate the impact of COVID-19 and the pandemic at large on trial participants. These discussions included key operational issues such as ensuring delivery of study medications, adaptations to study visits, enhanced COVID-19 related endpoint adjudication, and protocol and analytical plan revisions.\r\n\r\nOur findings may have important implications for establishing consensus on prospective contingency planning in future clinical trials.\r\n\r\ngov: NCT03619213.\r\n\r\nGOV: NCT03619213.", "doi": "10.1016/j.ahj.2023.05.013", "pmid": "37220822", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10200275"}, {"db": "pii", "key": "S0002-8703(23)00132-1"}, {"db": "ClinicalTrials.gov", "key": "NCT03619213"}], "notes": [], "created": "2023-10-04T05:10:17.305Z", "modified": "2023-10-04T06:33:48.984Z"}, {"entity": "publication", "iuid": "cde59eddc81548a1abc15d6ffe2a194a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cde59eddc81548a1abc15d6ffe2a194a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cde59eddc81548a1abc15d6ffe2a194a"}}, "title": "Multiple manifestations of uncontrolled asthma increase the risk of severe COVID-19.", "authors": [{"family": "Selberg", "given": "Stina", "initials": "S"}, {"family": "Karlsson Sundbaum", "given": "Johanna", "initials": "J"}, {"family": "Konradsen", "given": "Jon R", "initials": "JR"}, {"family": "Backman", "given": "Helena", "initials": "H"}, {"family": "Hedman", "given": "Linnea", "initials": "L"}, {"family": "Lindberg", "given": "Anne", "initials": "A"}, {"family": "Stridsman", "given": "Caroline", "initials": "C"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Respir Med", "issn": "1532-3064", "issn-l": "0954-6111", "volume": "216", "issue": null, "pages": "107308"}, "abstract": "Asthma control is of importance when assessing the risk of severe outcomes of COVID-19. The aim of this study was to explore associations of clinical characteristics and the effect of multiple manifestations of uncontrolled asthma with severe COVID-19.\r\n\r\nIn 2014-2020, adult patients with uncontrolled asthma, defined as Asthma Control Test (ACT) \u226419 were identified in the Swedish National Airway Register (SNAR) (n = 24533). The SNAR database, including clinical data, was linked with national registers to identify patients with severe COVID-19 (n = 221). The effect of multiple manifestations of uncontrolled asthma was based on: 1) ACT \u226415, 2) frequent exacerbations and 3) previous asthma inpatient/secondary care and evaluated stepwise. Poisson regression analyses were conducted with severe COVID-19 as the dependent variable.\r\n\r\nIn this cohort with uncontrolled asthma, obesity was the strongest independent risk factor for severe COVID-19 in both sexes, but even greater in men. Multiple manifestations of uncontrolled asthma were more common among those with severe COVID-19 vs. without: one, 45.7 vs. 42.3%, two, 18.1 vs. 9.1% and three, 5.0 vs. 2.1%. The risk ratio (RR) of severe COVID-19 increased with an increasing number of manifestations of uncontrolled asthma: one, RR 1.49 (95% CI 1.09-2.02), two, RR 2.42 (95% CI 1.64-3.57) and three, RR 2.96 (95% CI 1.57-5.60), when adjusted for sex, age, and BMI.\r\n\r\nIt is important to consider the effect of multiple manifestations of uncontrolled asthma and obesity when assessing patients with COVID-19, as this increases the risk of severe outcomes substantially.", "doi": "10.1016/j.rmed.2023.107308", "pmid": "37271301", "labels": {"Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10238115"}, {"db": "pii", "key": "S0954-6111(23)00196-8"}], "notes": [], "created": "2023-10-04T09:30:31.135Z", "modified": "2023-10-04T09:57:30.750Z"}, {"entity": "publication", "iuid": "a39c2ff1e6d94a1f951e4c3f635d65f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a39c2ff1e6d94a1f951e4c3f635d65f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a39c2ff1e6d94a1f951e4c3f635d65f0"}}, "title": "Long-term safety of COVID vaccination in individuals with idiopathic inflammatory myopathies: results from the COVAD study.", "authors": [{"family": "Doskaliuk", "given": "Bohdana", "initials": "B", "orcid": "0000-0003-1650-8928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5c55895beec4f5fa9fe0545f38b72d1.json"}}, {"family": "Ravichandran", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Saha", "given": "Sreoshy", "initials": "S", "orcid": "0000-0001-6745-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00238845dd4833ae51ffb75e2fe144.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Jagtap", "given": "Kshitij", "initials": "K", "orcid": "0000-0003-2729-737X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822b9da98e5d4eb2975ff97fe484933f.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Chen", "given": "Yi Ming", "initials": "YM", "orcid": "0000-0001-7593-3065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/795f1bf1d4824521a3301f7c50f62bc4.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Patel", "given": "Aarat", "initials": "A"}, {"family": "Pauling", "given": "John D", "initials": "JD", "orcid": "0000-0002-2793-2364", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e37709273d404d17a88c7c850777b99f.json"}}, {"family": "Wincup", "given": "Chris", "initials": "C", "orcid": "0000-0002-8742-8311", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a674f02e7f7f45f58167eb24f81502f3.json"}}, {"family": "Barman", "given": "Bhupen", "initials": "B", "orcid": "0000-0002-5433-1310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7747785ec5fa4743bc70bd20fbca10fd.json"}}, {"family": "Tehozol", "given": "Erick Adrian Zamora", "initials": "EAZ", "orcid": "0000-0002-7888-3961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a55c695ac4f4003993a2f511cca7739.json"}}, {"family": "Serrano", "given": "Jorge Rojas", "initials": "JR", "orcid": "0000-0001-6980-7898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/225fd8b396ac40f4a77f1ec229c086b6.json"}}, {"family": "La Torre", "given": "Ignacio Garc\u00eda-De", "initials": "IG", "orcid": "0000-0002-9261-678X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/086b85d66fb84b50bd51bbe5a979dfe3.json"}}, {"family": "Colunga-Pedraza", "given": "Iris J", "initials": "IJ", "orcid": "0000-0002-2786-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50e46ef2c7f44b39a1d28fea6a8e621d.json"}}, {"family": "Merayo-Chalico", "given": "Javier", "initials": "J", "orcid": "0000-0002-5870-0523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d74c0ab33cbe4df586e1a1add37d0e65.json"}}, {"family": "Chibuzo", "given": "Okwara Celestine", "initials": "OC", "orcid": "0000-0002-7727-5657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f415c3f3dea49cb90ae12def4278f00.json"}}, {"family": "Katchamart", "given": "Wanruchada", "initials": "W", "orcid": "0000-0002-8952-5967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9439933b38fb49aca8fdbb5038ff603c.json"}}, {"family": "Goo", "given": "Phonpen Akarawatcharangura", "initials": "PA", "orcid": "0009-0009-7611-9992", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3979fce5848e46d2af71814d96ad0406.json"}}, {"family": "Shumnalieva", "given": "Russka", "initials": "R", "orcid": "0000-0003-2321-6536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/933232cd7feb48ee81b5971f01f52e23.json"}}, {"family": "Hoff", "given": "Leonardo Santos", "initials": "LS", "orcid": "0000-0002-2083-4796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1df7af8caf024ca39c57278fdf18c766.json"}}, {"family": "Kibbi", "given": "Lina El", "initials": "LE", "orcid": "0000-0003-1710-9996", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11bb4fc524264c6897dec9642a0ef7cd.json"}}, {"family": "Halabi", "given": "Hussein", "initials": "H", "orcid": "0000-0002-5174-8292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb337090a5ab4461a07e8620bee1b4b9.json"}}, {"family": "Vaidya", "given": "Binit", "initials": "B", "orcid": "0000-0002-4840-8924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b2296d53fe14fc7a8415f26e03e1944.json"}}, {"family": "Shaharir", "given": "Syahrul Sazliyana", "initials": "SS", "orcid": "0000-0002-9068-8114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1e6310979d44d58b548c61c733412af.json"}}, {"family": "Hasan", "given": "A T M Tanveer", "initials": "ATMT", "orcid": "0000-0002-5332-3319", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ffdb3329292438fac4005923ee79012.json"}}, {"family": "Dey", "given": "Dzifa", "initials": "D", "orcid": "0000-0002-3339-5112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2615e43aeba34a0585679bdd14a1a324.json"}}, {"family": "Guti\u00e9rrez", "given": "Carlos Enrique Toro", "initials": "CET", "orcid": "0000-0002-6084-7049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/980e455c5d114caaaefb6e0b55eaa3b3.json"}}, {"family": "Caballero-Uribe", "given": "Carlo V", "initials": "CV", "orcid": "0000-0002-9845-8620", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42d86c9923424f9a804bab4580b993c3.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "COVAD study group", "given": "", "initials": ""}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Rheumatol Int", "issn": "1437-160X", "issn-l": null, "volume": "43", "issue": "9", "pages": "1651-1664"}, "abstract": "Limited evidence on long-term COVID-19 vaccine safety in patients with idiopathic inflammatory myopathies (IIMs) continues to contribute to vaccine hesitancy. We studied delayed-onset vaccine adverse events (AEs) in patients with IIMs, other systemic autoimmune and inflammatory disorders (SAIDs), and healthy controls (HCs), using data from the second COVID-19 Vaccination in Autoimmune Diseases (COVAD) study. A validated self-reporting e-survey was circulated by the COVAD study group (157 collaborators, 106 countries) from Feb-June 2022. We collected data on demographics, comorbidities, IIM/SAID details, COVID-19 history, and vaccination details. Delayed-onset (> 7 day) AEs were analyzed using regression models. A total of 15165 respondents undertook the survey, of whom 8759 responses from vaccinated individuals [median age 46 (35-58) years, 74.4% females, 45.4% Caucasians] were analyzed. Of these, 1390 (15.9%) had IIMs, 50.6% other SAIDs, and 33.5% HCs. Among IIMs, 16.3% and 10.2% patients reported minor and major AEs, respectively, and 0.72% (n = 10) required hospitalization. Notably patients with IIMs experienced fewer minor AEs than other SAIDs, though rashes were expectedly more than HCs [OR 4.0; 95% CI 2.2-7.0, p < 0.001]. IIM patients with active disease, overlap myositis, autoimmune comorbidities, and ChadOx1 nCOV-19 (Oxford/AstraZeneca) recipients reported AEs more often, while those with inclusion body myositis, and BNT162b2 (Pfizer) recipients reported fewer AEs. Vaccination is reassuringly safe in individuals with IIMs, with AEs, hospitalizations comparable to SAIDs, and largely limited to those with autoimmune multimorbidity and active disease. These observations may inform guidelines to identify high-risk patients warranting close monitoring in the post-vaccination period.", "doi": "10.1007/s00296-023-05345-y", "pmid": "37351634", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10348925"}, {"db": "pii", "key": "10.1007/s00296-023-05345-y"}], "notes": [], "created": "2023-10-04T09:32:26.527Z", "modified": "2023-10-04T11:07:53.247Z"}, {"entity": "publication", "iuid": "29b8c3b876cf42b588d620c08f0cd89f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/29b8c3b876cf42b588d620c08f0cd89f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/29b8c3b876cf42b588d620c08f0cd89f"}}, "title": "Immune responses to SARS-CoV-2 infection and vaccination in children.", "authors": [{"family": "Brodin", "given": "Petter", "initials": "P"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Semin Immunol", "issn": "1096-3618", "issn-l": null, "volume": "69", "issue": null, "pages": "101794"}, "abstract": "During the three years since SARS-CoV-2 infections were first described a wealth of information has been gathered about viral variants and their changing properties, the disease presentations they elicit and how the many vaccines developed in record time protect from COVID-19 severe disease in different populations. A general theme throughout the pandemic has been the observation that children and young people in general fare well, with mild symptoms during acute infection and full recovery thereafter. It has also become clear that this is not universally true, as some children develop severe COVID-19 hypoxic pneumonia and even succumb to the infection, while another group of children develop a rare but serious multisystem inflammatory syndrome (MIS-C) and some other children experience prolonged illness following acute infection, post-COVID. Here I will discuss some of the findings made to explain these diverse disease manifestations in children and young people infected by SARS-CoV-2. I will also discuss the vaccines developed at record speed and their efficacy in protecting children from disease.", "doi": "10.1016/j.smim.2023.101794", "pmid": "37536147", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null, "Category: Vaccines": null, "Funder: H2020": null}, "xrefs": [{"db": "pmc", "key": "PMC10281229"}, {"db": "pii", "key": "S1044-5323(23)00085-4"}], "notes": [], "created": "2023-10-05T08:01:56.621Z", "modified": "2023-10-05T08:38:56.090Z"}, {"entity": "publication", "iuid": "0b24a4a644084329838bcebf6a5eb49b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b24a4a644084329838bcebf6a5eb49b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b24a4a644084329838bcebf6a5eb49b"}}, "title": "ISTH guidelines for antithrombotic treatment in COVID-19: Endorsement by the Scandinavian Society of Anaesthesiology and Intensive Care Medicine.", "authors": [{"family": "Chew", "given": "Michelle S", "initials": "MS", "orcid": "0000-0003-2888-4111", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c68391bb66e94be1ac0a14d69430666e.json"}}, {"family": "Olkkola", "given": "Klaus T", "initials": "KT"}, {"family": "Kalliom\u00e4ki", "given": "Maija-Liisa", "initials": "M"}, {"family": "Rehn", "given": "Marius", "initials": "M"}, {"family": "Sigur\u00f0sson", "given": "Martin Ingi", "initials": "MI"}, {"family": "M\u00f8ller", "given": "Morten Hylander", "initials": "MH", "orcid": "0000-0002-6378-9673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1cf88aaa5c9436a8e70ddfe39cfe4e8.json"}}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": "67", "issue": "8", "pages": "1118-1120"}, "abstract": "The Clinical Practice Committee of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine endorses the ISTH guidelines for antithrombotic treatment in COVID-19. This evidence-based guideline serves as a useful decision aid for Nordic anaesthesiologists caring for patients with COVID-19.", "doi": "10.1111/aas.14259", "pmid": "37318942", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:31:21.293Z", "modified": "2023-10-04T10:49:25.736Z"}, {"entity": "publication", "iuid": "e6045f02c1c24528984fafc7101ed0d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6045f02c1c24528984fafc7101ed0d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6045f02c1c24528984fafc7101ed0d0"}}, "title": "Home care nurses' and managers' work environment during the Covid-19 pandemic: Increased workload, competing demands, and unsustainable trade-offs.", "authors": [{"family": "Rydenf\u00e4lt", "given": "Christofer", "initials": "C"}, {"family": "Persson", "given": "Johanna", "initials": "J"}, {"family": "Erlingsd\u00f3ttir", "given": "Gudbj\u00f6rg", "initials": "G"}, {"family": "Larsson", "given": "Roger", "initials": "R"}, {"family": "Johansson", "given": "Gerd", "initials": "G"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Appl Ergon", "issn": "1872-9126", "issn-l": null, "volume": "111", "issue": null, "pages": "104056"}, "abstract": "Little research exists on how home care nursing personnel have experienced the Covid-19 pandemic. This qualitative study explores the work environment related challenges nurses and managers in home care faced during the pandemic. We discuss these challenges in relation to the Demand-Control-Support Model and reflect on how the organizational dynamics associated with them can be understood using the competing pressures model. During the pandemic, home care nurses and managers experienced both an increased workload and psychosocial strain. For managers, the increased complexity of work was a major problem. We identify three key takeaways related to sustainable crisis management: 1) to support managers' ability to provide social support to their personnel, 2) to increase crisis communication preparedness, and 3) to apply a holistic perspective on protective gear use. We also conclude that the competing pressures model is useful when exploring the dynamics of the work environment in complex organizational contexts.", "doi": "10.1016/j.apergo.2023.104056", "pmid": "37257218", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10230855"}, {"db": "pii", "key": "S0003-6870(23)00094-7"}], "notes": [], "created": "2023-10-04T05:11:54.494Z", "modified": "2023-10-04T07:22:54.879Z"}, {"entity": "publication", "iuid": "2ecacb0f4eee4ef999fdf3621d9fe9bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ecacb0f4eee4ef999fdf3621d9fe9bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ecacb0f4eee4ef999fdf3621d9fe9bd"}}, "title": "High-Density Lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner.", "authors": [{"family": "Correa", "given": "Yubexi", "initials": "Y"}, {"family": "Del Giudice", "given": "Rita", "initials": "R"}, {"family": "Waldie", "given": "Sarah", "initials": "S"}, {"family": "Th\u00e9paut", "given": "Michel", "initials": "M"}, {"family": "Micciula", "given": "Samantha", "initials": "S"}, {"family": "Gerelli", "given": "Yuri", "initials": "Y"}, {"family": "Moulin", "given": "Martine", "initials": "M"}, {"family": "Delaunay", "given": "Clara", "initials": "C"}, {"family": "Fieschi", "given": "Franck", "initials": "F"}, {"family": "Pichler", "given": "Harald", "initials": "H"}, {"family": "Haertlein", "given": "Michael", "initials": "M"}, {"family": "Forsyth", "given": "V Trevor", "initials": "VT"}, {"family": "Le Brun", "given": "Anton", "initials": "A"}, {"family": "Moir", "given": "Michael", "initials": "M"}, {"family": "Russell", "given": "Robert A", "initials": "RA"}, {"family": "Darwish", "given": "Tamim", "initials": "T"}, {"family": "Brinck", "given": "Jonas", "initials": "J"}, {"family": "Wodaje", "given": "Tigist", "initials": "T"}, {"family": "Jansen", "given": "Martin", "initials": "M"}, {"family": "Mart\u00edn", "given": "C\u00e9sar", "initials": "C"}, {"family": "Roosen-Runge", "given": "Felix", "initials": "F"}, {"family": "C\u00e1rdenas", "given": "Marit\u00e9", "initials": "M"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "J Colloid Interface Sci", "issn": "1095-7103", "issn-l": null, "volume": "645", "issue": null, "pages": "627-638"}, "abstract": "There is a close relationship between the SARS-CoV-2 virus and lipoproteins, in particular high-density lipoprotein (HDL). The severity of the coronavirus disease 2019 (COVID-19) is inversely correlated with HDL plasma levels. It is known that the SARS-CoV-2 spike (S) protein binds the HDL particle, probably depleting it of lipids and altering HDL function. Based on neutron reflectometry (NR) and the ability of HDL to efflux cholesterol from macrophages, we confirm these observations and further identify the preference of the S protein for specific lipids and the consequent effects on HDL function on lipid exchange ability. Moreover, the effect of the S protein on HDL function differs depending on the individuals lipid serum profile. Contrasting trends were observed for individuals presenting low triglycerides/high cholesterol serum levels (LTHC) compared to high triglycerides/high cholesterol (HTHC) or low triglycerides/low cholesterol serum levels (LTLC). Collectively, these results suggest that the S protein interacts with the HDL particle and, depending on the lipid profile of the infected individual, it impairs its function during COVID-19 infection, causing an imbalance in lipid metabolism.", "doi": "10.1016/j.jcis.2023.04.137", "pmid": "37167912", "labels": {"Category: Proteins": null, "Funder: VR": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10147446"}, {"db": "pii", "key": "S0021-9797(23)00736-1"}], "notes": [], "created": "2023-10-04T05:08:45.936Z", "modified": "2023-10-04T05:21:15.338Z"}, {"entity": "publication", "iuid": "3acca2f1e999419c83c69f0d31ced23d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3acca2f1e999419c83c69f0d31ced23d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3acca2f1e999419c83c69f0d31ced23d"}}, "title": "High seroprevalence of SARS-CoV-2 antibodies in healthcare workers in COVID-19 wards indicates an occupational hazard-a prospective cohort study during the first year of the COVID-19 pandemic in Kalmar County, Sweden.", "authors": [{"family": "Hultqvist", "given": "Viktor", "initials": "V"}, {"family": "Bonnedahl", "given": "Jonas", "initials": "J"}, {"family": "Edwardsson", "given": "Jonathan", "initials": "J"}, {"family": "Tjernberg", "given": "Ivar", "initials": "I"}, {"family": "Ryd\u00e9n", "given": "Ingvar", "initials": "I"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "APMIS", "issn": "1600-0463", "issn-l": null, "volume": "131", "issue": "9", "pages": "491-497"}, "abstract": "The aim of this study is to report the seroprevalence of SARS-CoV-2 antibodies in healthcare workers with various risk of occupational exposure in Kalmar County, Sweden, during the first year of the coronavirus disease 2019 (COVID-19) pandemic. We performed SARS-CoV-2 antibody measurements at four time points, from May 2020 to May 2021, in 401 healthcare workers (HCW) at seven hospital wards and two residential care facilities, with different risk of SARS-CoV-2 exposure. Overall, the prevalence of SARS-CoV-2 antibodies in HCW in Kalmar County was high compared to similar studies from other countries and increased from May 2020 to May 2021. Initially, 14% of the participants were SARS-CoV-2 seropositive. This number increased to 18% in September and 21% in December 2020. In May 2021, the prevalence of antibodies to nucleocapsid antigen had increased to 28%, while antibodies to spike protein had increased to 95% due to vaccination. A large variation in seroprevalence between different wards was detected and HCW in a COVID-19 designated ward had significantly higher seroprevalence than HCW working in wards without COVID-19 patients, with a risk ratio of 7.28, (95% CI 2.38-22.33) in May 2020. Our findings suggest a relationship between occupational COVID-19 exposure and seropositivity which implies that efficient hygiene routines for health- and social care workers are essential to avoid that COVID-19 care will constitute an occupational hazard.", "doi": "10.1111/apm.13343", "pmid": "37462243", "labels": {"Type: Journal article": null, "Category: Serology": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:07:30.080Z", "modified": "2023-10-04T12:15:22.937Z"}, {"entity": "publication", "iuid": "e75991c1750c4f7786ccf65e35dbb1fb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e75991c1750c4f7786ccf65e35dbb1fb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e75991c1750c4f7786ccf65e35dbb1fb"}}, "title": "High fatigue scores in patients with idiopathic inflammatory myopathies: a multigroup comparative study from the COVAD e-survey.", "authors": [{"family": "Grignaschi", "given": "Silvia", "initials": "S"}, {"family": "Kim", "given": "Minchul", "initials": "M", "orcid": "0000-0001-9737-6255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd2952c6167b4733bfbce019a162b310.json"}}, {"family": "Zanframundo", "given": "Giovanni", "initials": "G"}, {"family": "Ravichandran", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Kardes", "given": "Sinan", "initials": "S", "orcid": "0000-0002-6311-8634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2900c3ca00da476a8914574384a3c9c2.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "COVAD study group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Rheumatol Int", "issn": "1437-160X", "issn-l": null, "volume": "43", "issue": "9", "pages": "1637-1649"}, "abstract": "Idiopathic inflammatory myopathies (IIMs) confer a significant risk of disability and poor quality of life, though fatigue, an important contributing factor, remains under-reported in these individuals. We aimed to compare and analyze differences in visual analog scale (VAS) scores (0-10 cm) for fatigue (VAS-F) in patients with IIMs, non-IIM systemic autoimmune diseases (SAIDs), and healthy controls (HCs). We performed a cross-sectional analysis of the data from the COVID-19 Vaccination in Autoimmune Diseases (COVAD) international patient self-reported e-survey. The COVAD survey was circulated from December 2020 to August 2021, and details including demographics, COVID-19 history, vaccination details, SAID details, global health, and functional status were collected from adult patients having received at least one COVID-19 vaccine dose. Fatigue experienced 1 week prior to survey completion was assessed using a single-item 10 cm VAS. Determinants of fatigue were analyzed in regression models. Six thousand nine hundred and eighty-eight respondents (mean age 43.8 years, 72% female; 55% White) were included in the analysis. The overall VAS-F score was 3 (IQR 1-6). Patients with IIMs had similar fatigue scores (5, IQR 3-7) to non-IIM SAIDs [5 (IQR 2-7)], but higher compared to HCs (2, IQR 1-5; P < 0.001), regardless of disease activity. In adjusted analysis, higher VAS-F scores were seen in females (reference female; coefficient -0.17; 95%CI -0.21 to -13; P < 0.001) and Caucasians (reference Caucasians; coefficient -0.22; 95%CI -0.30 to -0.14; P < 0.001 for Asians and coefficient -0.08; 95%CI -0.13 to 0.30; P = 0.003 for Hispanics) in our cohort. Our study found that patients with IIMs exhibit considerable fatigue, similar to other SAIDs and higher than healthy individuals. Women and Caucasians experience greater fatigue scores, allowing identification of stratified groups for optimized multidisciplinary care and improve outcomes such as quality of life.", "doi": "10.1007/s00296-023-05344-z", "pmid": "37314497", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Funder: H2020": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10265550"}, {"db": "pii", "key": "10.1007/s00296-023-05344-z"}], "notes": [], "created": "2023-10-04T09:32:31.580Z", "modified": "2023-10-04T11:09:52.683Z"}, {"entity": "publication", "iuid": "bf31b0ac62cb410db050e9b0a752e1aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf31b0ac62cb410db050e9b0a752e1aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf31b0ac62cb410db050e9b0a752e1aa"}}, "title": "Exploring the learning needs of clinicians in Belgium and Sweden regarding prone positioning and skin damage prevention: A qualitative study.", "authors": [{"family": "Fourie", "given": "Anika", "initials": "A"}, {"family": "Karlberg-Traav", "given": "Malin", "initials": "M"}, {"family": "Dahlberg", "given": "Karuna", "initials": "K"}, {"family": "Hanssens", "given": "Valerie", "initials": "V"}, {"family": "Smet", "given": "Steven", "initials": "S"}, {"family": "Jaensson", "given": "Maria", "initials": "M"}, {"family": "Beeckman", "given": "Dimitri", "initials": "D"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Nurse Educ Today", "issn": "1532-2793", "issn-l": null, "volume": "128", "issue": null, "pages": "105860"}, "abstract": "During the coronavirus pandemic (COVID -19), the use of prone positioning in critically ill patients with acute respiratory distress syndrome (ARDS) increased substantially. As a result, clinicians had to (re)learn how to treat the patient in the prone position while preventing adverse events such as pressure ulcers, skin tears and moisture-associated skin damage.\r\n\r\nThe purpose of the study was to determine participants' learning needs related to patients in the prone position and the prevention of skin damage, such as pressure ulcers, and what they perceived as a positive or negative learning experience.\r\n\r\nThis study used a qualitative methodological framework and employed an exploratory design.\r\n\r\nA purposive sample of clinicians (n = 20) with direct or indirect work experience with prone ventilated patients was recruited in Belgium and Sweden.\r\n\r\nIndividual semi-structured interviews were conducted in Belgium and Sweden between February and August 2022. Data were analysed thematically using an inductive approach. The COREQ guideline was utilised to comprehensively report on the study.\r\n\r\nTwo themes were identified: 'Adapting to a crisis' and 'How to learn', with the latter having two subthemes: 'balancing theory and practice' and 'co-creating knowledge'. Unexpected circumstances necessitated a personal adaption, a change in learning methods and a pragmatic adaptation of protocols, equipment and working procedures. Participants recognised a multifaceted educational approach which would contribute to a positive learning experience regarding prone positioning and skin damage prevention. The importance of poising theoretical teaching with practical hands-on training was highlighted with an emphasis on interaction, discussion, and networking between peers.\r\n\r\nThe study findings highlight learning approaches which may help inform the development of befitting educational resources for clinicians. Prone therapy for ARDS patients is not limited to the pandemic. Therefore, educational efforts should continue to ensure patient safety in this important area.", "doi": "10.1016/j.nedt.2023.105860", "pmid": "37302346", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10245459"}, {"db": "pii", "key": "S0260-6917(23)00154-5"}], "notes": [], "created": "2023-10-04T09:33:11.219Z", "modified": "2023-10-04T11:19:39.322Z"}, {"entity": "publication", "iuid": "84557420b4864451a9d76aff69578f14", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84557420b4864451a9d76aff69578f14.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84557420b4864451a9d76aff69578f14"}}, "title": "Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2.", "authors": [{"family": "Yang", "given": "Pei-Pei", "initials": "P"}, {"family": "Ye", "given": "Xin-Wei", "initials": "X"}, {"family": "Liu", "given": "Mei-Qin", "initials": "M"}, {"family": "Yang", "given": "Jin-Xuan", "initials": "J"}, {"family": "Feng", "given": "Xiao-Li", "initials": "X"}, {"family": "Li", "given": "Yi-Jing", "initials": "Y"}, {"family": "Zhang", "given": "Kuo", "initials": "K"}, {"family": "Liang", "given": "Hong-Wen", "initials": "H"}, {"family": "Yi", "given": "Yu", "initials": "Y"}, {"family": "Wang", "given": "Lei", "initials": "L", "orcid": "0000-0003-1405-9815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30c6dba79ded4fd1b628ddfd5daf494f.json"}}, {"family": "Liu", "given": "Yi-Xuan", "initials": "Y"}, {"family": "Yang", "given": "Xing-Lou", "initials": "X"}, {"family": "Shi", "given": "Zheng-Li", "initials": "Z"}, {"family": "Feng", "given": "Li-Qiang", "initials": "L"}, {"family": "Chen", "given": "Ling", "initials": "L"}, {"family": "Xue", "given": "Yintong", "initials": "Y"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}, {"family": "Wang", "given": "Hao", "initials": "H"}, {"family": "Zhao", "given": "Yuliang", "initials": "Y"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Adv Healthc Mater", "issn": "2192-2659", "issn-l": null, "volume": "12", "issue": "24", "pages": "e2300673"}, "abstract": "The viral spike (S) protein on the surface of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin-converting enzyme 2 (ACE2) receptors on the host cells, facilitating its entry and infection. Here, functionalized nanofibers targeting the S protein with peptide sequences of IRQFFKK, WVHFYHK and NSGGSVH, which are screened from a high-throughput one-bead one-compound screening strategy, are designed and prepared. The flexible nanofibers support multiple binding sites and efficiently entangle SARS-CoV-2, forming a nanofibrous network that blocks the interaction between the S protein of SARS-CoV-2 and the ACE2 on host cells, and efficiently reduce the invasiveness of SARS-CoV-2. In summary, nanofibers entangling represents a smart nanomedicine for the prevention of SARS-CoV-2.", "doi": "10.1002/adhm.202300673", "pmid": "37139567", "labels": {"Category: Proteins": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:11:52.046Z", "modified": "2023-10-04T07:22:10.555Z"}, {"entity": "publication", "iuid": "4ec4a4b1a1fc4bcda2fabd8ba091ed1b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ec4a4b1a1fc4bcda2fabd8ba091ed1b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ec4a4b1a1fc4bcda2fabd8ba091ed1b"}}, "title": "Digital health funding for COVID-19 vaccine deployment across four major donor agencies.", "authors": [{"family": "Helld\u00e9n", "given": "Daniel", "initials": "D"}, {"family": "Tesfaye", "given": "Sophia", "initials": "S"}, {"family": "Gachen", "given": "Carine", "initials": "C"}, {"family": "Lindstrand", "given": "Ann", "initials": "A"}, {"family": "K\u00e4llander", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "The Lancet Digital Health", "issn": "2589-7500", "issn-l": null, "volume": "5", "issue": "9", "pages": "e627-e631"}, "abstract": "The international response to the COVID-19 pandemic provided opportunities for countries to use digital technologies for vaccine deployment and associated activities, but misaligned digital investments could weaken or fragment national systems. In this review of 311 funding applications from 120 country governments to four donor agencies (UNICEF; Gavi, the Vaccine Alliance; the Global Fund to Fight AIDS, Tuberculosis and Malaria; and the World Bank) up to May 1, 2022, we found that 272 (87%) of the applications included at least one digital aspect and that substantial funding has been dedicated towards digital aspects from donors. The majority of digital aspects concerned immunisation information systems, vaccine acceptance and uptake, and COVID-19 surveillance. As the global community sets its sights on a COVID-19-free world, continued coordinated investments in digital health and health information systems for pandemic preparedness and response will be key to strengthening the resilience of health systems.", "doi": "10.1016/S2589-7500(23)00134-6", "pmid": "37625897", "labels": {"Category: Other": null, "Category: Vaccines": null, "Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2589-7500(23)00134-6"}], "notes": [], "created": "2023-10-05T08:08:39.770Z", "modified": "2023-10-06T04:31:10.944Z"}, {"entity": "publication", "iuid": "63b101b848ae4630a61c9b89c8877dcf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63b101b848ae4630a61c9b89c8877dcf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63b101b848ae4630a61c9b89c8877dcf"}}, "title": "Cognitive ability, health policy, and the dynamics of COVID-19 vaccination.", "authors": [{"family": "Elinder", "given": "Mikael", "initials": "M"}, {"family": "Erixson", "given": "Oscar", "initials": "O"}, {"family": "\u00d6hman", "given": "Mattias", "initials": "M"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "J Health Econ", "issn": "1879-1646", "issn-l": null, "volume": "91", "issue": null, "pages": "102802"}, "abstract": "We examine the relationship between cognitive ability and prompt COVID-19 vaccination using individual-level data on more than 700,000 individuals in Sweden. We find a strong positive association between cognitive ability and swift vaccination, which remains even after controlling for confounding variables with a twin-design. The results suggest that the complexity of the vaccination decision may make it difficult for individuals with lower cognitive abilities to understand the benefits of vaccination. Consistent with this, we show that simplifying the vaccination decision through pre-booked vaccination appointments alleviates almost all of the inequality in vaccination behavior.", "doi": "10.1016/j.jhealeco.2023.102802", "pmid": "37672962", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0167-6296(23)00079-6"}], "notes": [], "created": "2023-10-06T06:56:51.941Z", "modified": "2023-10-06T11:31:47.711Z"}, {"entity": "publication", "iuid": "a7e27207e7a94cd8aff08881f2864f65", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7e27207e7a94cd8aff08881f2864f65.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7e27207e7a94cd8aff08881f2864f65"}}, "title": "A standardised protocol for relative SARS-CoV-2 variant severity assessment, applied to Omicron BA.1 and Delta in six European countries, October 2021 to February 2022.", "authors": [{"family": "Nyberg", "given": "Tommy", "initials": "T"}, {"family": "Bager", "given": "Peter", "initials": "P"}, {"family": "Svalgaard", "given": "Ingrid Bech", "initials": "IB"}, {"family": "Bejko", "given": "Dritan", "initials": "D"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Evans", "given": "Josie", "initials": "J"}, {"family": "Krause", "given": "Tyra Grove", "initials": "TG"}, {"family": "McMenamin", "given": "Jim", "initials": "J"}, {"family": "Mossong", "given": "Jo\u00ebl", "initials": "J"}, {"family": "Mutch", "given": "Heather", "initials": "H"}, {"family": "Omokanye", "given": "Ajibola", "initials": "A"}, {"family": "Peralta-Santos", "given": "Andr\u00e9", "initials": "A"}, {"family": "Pinto-Leite", "given": "Pedro", "initials": "P"}, {"family": "Starrfelt", "given": "Jostein", "initials": "J"}, {"family": "Thelwall", "given": "Simon", "initials": "S"}, {"family": "Veneti", "given": "Lamprini", "initials": "L"}, {"family": "Whittaker", "given": "Robert", "initials": "R"}, {"family": "Wood", "given": "John", "initials": "J"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "Presanis", "given": "Anne M", "initials": "AM"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "36", "pages": null}, "abstract": "Several SARS-CoV-2 variants that evolved during the COVID-19 pandemic have appeared to differ in severity, based on analyses of single-country datasets. With decreased testing and sequencing, international collaborative studies will become increasingly important for timely assessment of the severity of new variants. Therefore, a joint WHO Regional Office for Europe and ECDC working group was formed to produce and pilot a standardised study protocol to estimate relative case-severity of SARS-CoV-2 variants during periods when two variants were co-circulating. The study protocol and its associated statistical analysis code was applied by investigators in Denmark, England, Luxembourg, Norway, Portugal and Scotland to assess the severity of cases with the Omicron BA.1 virus variant relative to Delta. After pooling estimates using meta-analysis methods (random effects estimates), the risk of hospital admission (adjusted hazard ratio (aHR) = 0.41; 95% confidence interval (CI): 0.31-0.54), admission to intensive care unit (aHR = 0.12; 95% CI: 0.05-0.27) and death (aHR = 0.31; 95% CI: 0.28-0.35) was lower for Omicron BA.1 compared with Delta cases. The aHRs varied by age group and vaccination status. In conclusion, this study demonstrates the feasibility of conducting variant severity analyses in a multinational collaborative framework and adds evidence for the reduced severity of the Omicron BA.1 variant.", "doi": "10.2807/1560-7917.ES.2023.28.36.2300048", "pmid": "37676146", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10486193"}], "notes": [], "created": "2023-10-06T06:55:12.366Z", "modified": "2023-10-06T10:47:20.690Z"}, {"entity": "publication", "iuid": "4e8767b8b6054dbeaab6dfe907ae7b97", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4e8767b8b6054dbeaab6dfe907ae7b97.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4e8767b8b6054dbeaab6dfe907ae7b97"}}, "title": "A randomised phase 2a study to investigate the effects of blocking interleukin-33 with tozorakimab in patients hospitalised with COVID-19: ACCORD-2.", "authors": [{"family": "Wilkinson", "given": "Tom", "initials": "T", "orcid": "0000-0003-1771-3851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3239563fcce145ee8d4ab7d35b43a2ad.json"}}, {"family": "De Soyza", "given": "Anthony", "initials": "A", "orcid": "0000-0002-8566-0344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1dc6ec2385014db6aad8bbd5a246ed68.json"}}, {"family": "Carroll", "given": "Miles", "initials": "M", "orcid": "0000-0002-7026-7187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d55790d02914f88a2df413b99c59749.json"}}, {"family": "Chalmers", "given": "James D", "initials": "JD", "orcid": "0000-0001-5514-7868", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37d2cc32f79448a28df83f9ee728cac3.json"}}, {"family": "Crooks", "given": "Michael G", "initials": "MG"}, {"family": "Griffiths", "given": "Gareth", "initials": "G"}, {"family": "Shankar-Hari", "given": "Manu", "initials": "M", "orcid": "0000-0002-5338-2538", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/490ca05f76804685bf9fec3adfa0b0a0.json"}}, {"family": "Ho", "given": "Ling-Pei", "initials": "L"}, {"family": "Horsley", "given": "Alex", "initials": "A", "orcid": "0000-0003-1828-0058", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/088d99884f4642dab5297a7864ef1fe1.json"}}, {"family": "Kell", "given": "Chris", "initials": "C"}, {"family": "Lara", "given": "Beatriz", "initials": "B", "orcid": "0000-0003-0090-8206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d115da5d1e0246af8f08f70a4e9266c4.json"}}, {"family": "Mishra", "given": "Biswa", "initials": "B"}, {"family": "Moate", "given": "Rachel", "initials": "R"}, {"family": "Page", "given": "Clive", "initials": "C"}, {"family": "Pandya", "given": "Hitesh", "initials": "H"}, {"family": "Raw", "given": "Jason", "initials": "J"}, {"family": "Reid", "given": "Fred", "initials": "F"}, {"family": "Saralaya", "given": "Dinesh", "initials": "D"}, {"family": "Scott", "given": "Ian C", "initials": "IC"}, {"family": "Siddiqui", "given": "Salman", "initials": "S"}, {"family": "Ustianowski", "given": "Andy", "initials": "A"}, {"family": "van Zuydam", "given": "Natalie", "initials": "N"}, {"family": "Woodcock", "given": "Ashley", "initials": "A", "orcid": "0000-0002-5428-8578", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d3fb0de3ce5b4352876837cd518b332a.json"}}, {"family": "Singh", "given": "Dave", "initials": "D", "orcid": "0000-0001-8918-7075", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f87ffcbf55547c7832731e3479d55bd.json"}}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "ERJ Open Res", "issn": "2312-0541", "issn-l": null, "volume": "9", "issue": "5", "pages": null}, "abstract": "Increased serum interleukin (IL)-33 predicts poor outcomes in patients hospitalised with coronavirus disease 2019 (COVID-19). We examined the efficacy and safety of tozorakimab, a monoclonal antibody that neutralises IL-33, in improving outcomes in ACCORD-2 (EudraCT: 2020-001736-95).\r\n\r\nACCORD-2 was an open-label, phase 2a study in adults hospitalised with COVID-19. Patients were randomised 1:1 to tozorakimab 300 mg plus standard of care (SoC) or SoC alone. The primary end-point was time to clinical response (sustained clinical improvement of \u22652 points on the World Health Organization ordinal scale, discharge from hospital or fit for discharge) by day 29. Other end-points included death or respiratory failure, mortality and intensive care unit admission by day 29, and safety. Serum IL-33/soluble stimulated-2 (sST2) complex levels were measured by high-sensitivity immunoassay.\r\n\r\nEfficacy analyses included 97 patients (tozorakimab+SoC, n=53; SoC, n=44). Median time to clinical response did not differ between the tozorakimab and SoC arms (8.0 and 9.5 days, respectively; HR 0.96, 80% CI 0.70-1.31; one-sided p=0.33). Tozorakimab was well tolerated and the OR for risk of death or respiratory failure with treatment versus SoC was 0.55 (80% CI 0.27-1.12; p=0.26), while the OR was 0.31 (80% CI 0.09-1.06) in patents with high baseline serum IL-33/sST2 complex levels.\r\n\r\nOverall, ACCORD-2 results suggest that tozorakimab could be a novel therapy for patients hospitalised with COVID-19, warranting further investigation in confirmatory phase 3 studies.", "doi": "10.1183/23120541.00249-2023", "pmid": "37868151", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10588785"}, {"db": "pii", "key": "00249-2023"}], "notes": [], "created": "2023-11-01T13:34:04.363Z", "modified": "2023-11-02T07:40:47.429Z"}, {"entity": "publication", "iuid": "0253ecf537a940588afeebc1bcd7406c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0253ecf537a940588afeebc1bcd7406c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0253ecf537a940588afeebc1bcd7406c"}}, "title": "Alcohol consumption under lockdown measures during the COVID-19 pandemic in three Nordic countries.", "authors": [{"family": "Gunnerlind", "given": "Oscar", "initials": "O", "orcid": "0000-0003-2856-0192", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd5a54cbaeee4a89932f208c10fd5d0a.json"}}, {"family": "Lundqvist", "given": "Robert", "initials": "R"}, {"family": "Ott", "given": "Michael", "initials": "M"}, {"family": "Werneke", "given": "Ursula", "initials": "U", "orcid": "0000-0002-5023-3254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eed3b002ddb4cbba141cbfdc8d3f032.json"}}], "type": "journal article", "published": "2023-08-31", "journal": {"title": "Int J Soc Psychiatry", "issn": "1741-2854", "issn-l": null, "volume": null, "issue": null, "pages": "207640231194486"}, "abstract": "At the beginning of the COVID-19 pandemic, concerns arose about a possible rise in alcohol consumption. Early surveys, however, more commonly pointed towards a decrease of alcohol use. But studies based on self-reports may underestimate alcohol use. They also depend on the population sampled. Because of border closures and gastronomy restrictions, countries with centralised alcohol sales provided a unique opportunity to study total domestic consumption during the pandemic without influence of private import or reliance on self-reports.\r\n\r\nWe examined the correlation between alcohol sales and national COVID-19 restrictions in three such countries, Finland, Norway and Sweden.\r\n\r\nWe conducted this study as a mirror image study, comparing alcohol sales during the first 2 years of the COVID-19 pandemic with the two preceding years. We explored hours of daylight/season as potential confounders.\r\n\r\nWe found no relevant change in alcohol sales during the pandemic years for Finland or Sweden. For Norway, there was a level-change in sales, which could be explained by decreased imports. Sales followed a seasonal pattern. In all three countries, the initial pandemic increase in alcohol sales coincided with an underlying annually recurring seasonal variation.\r\n\r\nThe COVID-19 pandemic had less of an impact on alcohol consumption in the three Nordic countries than could intuitively be expected. The increase of alcohol sales at the beginning of the COVID-19 pandemic coincided with a seasonal rise following a pre-pandemic pattern. Therefore, caution should be exercised with drawing conclusions from data with a short time perspective to avoid attribution bias.", "doi": "10.1177/00207640231194486", "pmid": "37650471", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:02:41.240Z", "modified": "2023-10-05T08:49:41.393Z"}, {"entity": "publication", "iuid": "659e1b32ed7d47b7a951e42b964496a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/659e1b32ed7d47b7a951e42b964496a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/659e1b32ed7d47b7a951e42b964496a6"}}, "title": "Addressing health inequity during the COVID-19 pandemic through primary health care and public health collaboration: a multiple case study analysis in eight high-income countries.", "authors": [{"family": "Vanden Bossche", "given": "Dorien", "initials": "D"}, {"family": "Zhao", "given": "Q Jane", "initials": "QJ"}, {"family": "Ares-Blanco", "given": "Sara", "initials": "S"}, {"family": "Pe\u00f1a", "given": "Maria Pilar Astier", "initials": "MPA"}, {"family": "Decat", "given": "Peter", "initials": "P"}, {"family": "Kondo", "given": "Naoki", "initials": "N"}, {"family": "Kroneman", "given": "Madelon", "initials": "M"}, {"family": "Nishioka", "given": "Daisuke", "initials": "D"}, {"family": "Petrazzuoli", "given": "Ferdinando", "initials": "F"}, {"family": "Rortveit", "given": "Guri", "initials": "G"}, {"family": "Schaubroeck", "given": "Emmily", "initials": "E"}, {"family": "Stark", "given": "Stefanie", "initials": "S"}, {"family": "Pinto", "given": "Andrew D", "initials": "AD"}, {"family": "Willems", "given": "Sara", "initials": "S"}], "type": "journal article", "published": "2023-08-31", "journal": {"title": "Int J Equity Health", "issn": "1475-9276", "issn-l": null, "volume": "22", "issue": "1", "pages": "171"}, "abstract": "The COVID-19 pandemic substantially magnified the inequity gaps among vulnerable populations. Both public health (PH) and primary health care (PHC) have been crucial in addressing the challenges posed by the pandemic, especially in the area of vulnerable populations. However, little is known about the intersection between PH and PHC as a strategy to mitigate the inequity gap. This study aims to assess the collaboration between PHC and PH with a focus on addressing the health needs of vulnerable populations during the COVID-19 pandemic across jurisdictions.\r\n\r\nWe analyzed and compared data from jurisdictional reports of COVID-19 pandemic responses in PHC and PH in Belgium, Canada (Ontario), Germany, Italy, Japan, the Netherlands, Norway, and Spain from 2020 to 2021.\r\n\r\nFour themes emerge from the analysis: (1) the majority of the countries implemented outreach strategies targeting vulnerable groups as a means to ensure continued access to PHC; (2) digital assessment in PHC was found to be present across all the countries; (3) PHC was insufficiently represented at the decision-making level; (4) there is a lack of clear communication channels between PH and PHC in all the countries.\r\n\r\nThis study identified opportunities for collaboration between PHC and PH to reduce inequity gaps and to improve population health, focusing on vulnerable populations. The COVID-19 response in these eight countries has demonstrated the importance of an integrated PHC system. Consequently, the development of effective strategies for responding to and planning for pandemics should take into account the social determinants of health in order to mitigate the unequal impact of COVID-19. Careful, intentional coordination between PH and PHC should be established in normal times as a basis for effective response during future public health emergencies. The pandemic has provided significant insights on how to strengthen health systems and provide universal access to healthcare by fostering stronger connections between PH and PHC.", "doi": "10.1186/s12939-023-01968-6", "pmid": "37653472", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10472729"}, {"db": "pii", "key": "10.1186/s12939-023-01968-6"}], "notes": [], "created": "2023-10-06T06:56:38.772Z", "modified": "2023-10-06T11:24:37.724Z"}, {"entity": "publication", "iuid": "f434c2ddde2e47c7b06209913c57337d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f434c2ddde2e47c7b06209913c57337d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f434c2ddde2e47c7b06209913c57337d"}}, "title": "Super-resolution proximity labeling reveals anti-viral protein network and its structural changes against SARS-CoV-2 viral proteins.", "authors": [{"family": "Lee", "given": "Yun-Bin", "initials": "Y"}, {"family": "Jung", "given": "Minkyo", "initials": "M"}, {"family": "Kim", "given": "Jeesoo", "initials": "J"}, {"family": "Charles", "given": "Afandi", "initials": "A"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Kang", "given": "Jiwoong", "initials": "J"}, {"family": "Kang", "given": "Myeong-Gyun", "initials": "M"}, {"family": "Kwak", "given": "Chulhwan", "initials": "C"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Kim", "given": "Jong-Seo", "initials": "J"}, {"family": "Mun", "given": "Ji Young", "initials": "JY"}, {"family": "Rhee", "given": "Hyun-Woo", "initials": "H"}], "type": "journal article", "published": "2023-08-29", "journal": {"title": "Cell Rep", "issn": "2211-1247", "issn-l": null, "volume": "42", "issue": "8", "pages": "112835"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in human cells by interacting with host factors following infection. To understand the virus and host interactome proximity, we introduce a super-resolution proximity labeling (SR-PL) method with a \"plug-and-playable\" PL enzyme, TurboID-GBP (GFP-binding nanobody protein), and we apply it for interactome mapping of SARS-CoV-2 ORF3a and membrane protein (M), which generates highly perturbed endoplasmic reticulum (ER) structures. Through SR-PL analysis of the biotinylated interactome, 224 and 272 peptides are robustly identified as ORF3a and M interactomes, respectively. Within the ORF3a interactome, RNF5 co-localizes with ORF3a and generates ubiquitin modifications of ORF3a that can be involved in protein degradation. We also observe that the SARS-CoV-2 infection rate is efficiently reduced by the overexpression of RNF5 in host cells. The interactome data obtained using the SR-PL method are presented at https://sarscov2.spatiomics.org. We hope that our method will contribute to revealing virus-host interactions of other viruses in an efficient manner.", "doi": "10.1016/j.celrep.2023.112835", "pmid": "37478010", "labels": {"Type: Journal article": null, "Category: Proteins": null}, "xrefs": [{"db": "pii", "key": "S2211-1247(23)00846-X"}], "notes": [], "created": "2023-10-04T12:10:26.384Z", "modified": "2023-10-04T13:13:13.239Z"}, {"entity": "publication", "iuid": "90c3a6e606bf4d3ca62e2f8c6def2741", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90c3a6e606bf4d3ca62e2f8c6def2741.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90c3a6e606bf4d3ca62e2f8c6def2741"}}, "title": "Prepandemic personal concentrations of per- and polyfluoroalkyl substances (PFAS) and other pollutants: Specific and combined effects on the incidence of COVID-19 disease and SARS-CoV-2 infection.", "authors": [{"family": "Pumarega", "given": "Jos\u00e9", "initials": "J"}, {"family": "Gasull", "given": "Magda", "initials": "M"}, {"family": "Koponen", "given": "Jani", "initials": "J"}, {"family": "Campi", "given": "Laura", "initials": "L"}, {"family": "Rantakokko", "given": "Panu", "initials": "P"}, {"family": "Henr\u00edquez-Hern\u00e1ndez", "given": "Luis A", "initials": "LA"}, {"family": "Aguilar", "given": "Ruth", "initials": "R"}, {"family": "Donat-Vargas", "given": "Carolina", "initials": "C"}, {"family": "Zumbado", "given": "Manuel", "initials": "M"}, {"family": "Villar-Garc\u00eda", "given": "Judit", "initials": "J"}, {"family": "Rius", "given": "Cristina", "initials": "C"}, {"family": "Santiago-D\u00edaz", "given": "Pablo", "initials": "P"}, {"family": "Vidal", "given": "Marta", "initials": "M"}, {"family": "Jimenez", "given": "Alfons", "initials": "A"}, {"family": "Iglesias", "given": "Mar", "initials": "M"}, {"family": "Doba\u00f1o", "given": "Carlota", "initials": "C"}, {"family": "Moncunill", "given": "Gemma", "initials": "G"}, {"family": "Porta", "given": "Miquel", "initials": "M"}], "type": "journal article", "published": "2023-08-29", "journal": {"title": "Environ Res", "issn": "1096-0953", "issn-l": "0013-9351", "volume": "237", "issue": "Pt 2", "pages": "116965"}, "abstract": "To investigate the specific and combined effects of personal concentrations of some per- and polyfluoroalkyl substances (PFAS), other persistent organic pollutants (POPs), and chemical elements -measured in individuals' blood several years before the pandemic- on the development of SARS-CoV-2 infection and COVID-19 disease in the general population.\r\n\r\nWe conducted a prospective cohort study in 240 individuals from the general population of Barcelona. PFAS, other POPs, and chemical elements were measured in plasma, serum, and whole blood samples, respectively, collected in 2016-2017. PFAS were analyzed by liquid chromatography-triple quadrupole mass spectrometry. SARS-CoV-2 infection was detected by rRT-PCR in nasopharyngeal swabs and/or antibody serology in blood samples collected in 2020-2021.\r\n\r\nNo individual PFAS nor their mixtures were significantly associated with SARS-CoV-2 seropositivity or COVID-19 disease. Previously identified mixtures of POPs and elements (Porta et al., 2023) remained significantly associated with seropositivity and COVID-19 when adjusted for PFAS (all OR > 4 or p < 0.05). Nine chemicals comprised mixtures associated with COVID-19: thallium, ruthenium, lead, benzo[b]fluoranthene, DDD, other DDT-related compounds, manganese, tantalum, and aluminium. And nine chemicals comprised the mixtures more consistently associated with SARS-CoV-2 seropositivity: thallium, ruthenium, lead, benzo[b]fluoranthene, DDD, gold, and (protectively) selenium, indium, and iron.\r\n\r\nThe PFAS studied were not associated with SARS-CoV-2 seropositivity or COVID-19. The results confirm the associations between personal blood concentrations of some POPs and chemical elements and the risk of COVID-19 and SARS-CoV-2 infection in what remains the only prospective and population-based cohort study on the topic. Mixtures of POPs and chemical elements may contribute to explain the heterogeneity in the risks of SARS-CoV-2 infection and COVID-19 in the general population.", "doi": "10.1016/j.envres.2023.116965", "pmid": "37652221", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0013-9351(23)01769-3"}], "notes": [], "created": "2023-10-06T06:52:13.472Z", "modified": "2023-10-06T08:27:52.331Z"}, {"entity": "publication", "iuid": "670370e2a10447ef97d64d892dc77928", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/670370e2a10447ef97d64d892dc77928.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/670370e2a10447ef97d64d892dc77928"}}, "title": "Long-term survival after intensive care for COVID-19: a nationwide cohort study of more than 8000 patients.", "authors": [{"family": "H\u00e4ggl\u00f6f", "given": "Elsa", "initials": "E", "orcid": "0000-0001-7741-8980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9298066f63df45aaa4ce3d8b54d14fb6.json"}}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "Zettersten", "given": "Erik", "initials": "E"}, {"family": "Engerstr\u00f6m", "given": "Lars", "initials": "L"}, {"family": "Larsson", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2023-08-29", "journal": {"title": "Ann Intensive Care", "issn": "2110-5820", "issn-l": null, "volume": "13", "issue": "1", "pages": "76"}, "abstract": "Was it worth it-what is the outcome after the extended ICU (intensive care unit) length of stay for COVID-19 patients? Surprisingly, data on long-term mortality in large cohorts are lacking. We investigate long-term mortality including differences between men and women, as previous studies show that men generally suffer a more severe course of COVID-19 in terms of severity of illness and short-term mortality.\r\n\r\nNationwide cohort including all adult COVID-19 patients admitted to Swedish ICUs until August 12, 2022. Primary outcome was 360-day mortality after ICU admission. Logistic regression was used to estimate associations between demographics, comorbidities, clinical characteristics and mortality.\r\n\r\nIn total, 8392 patients were included. Median (IQR) age was 63 (52-72) years and the majority (70.1%) were men. Among the 7390 patients with complete 360-day mortality data, 1775 (24.4%) patients died within 30 days, 2125 (28.8%) within 90 days and 2206 (29.8%) within 360 days from ICU admission. 360-day mortality was 27.1% in women and 31.0% in men. Multivariable logistic regression analysis showed increased risk of 360-day mortality in men compared to women (OR: 1.33, 95% CI: 1.17-1.52). Other variables associated with poor 360-day mortality were age, cardiac disease, COPD/asthma, diabetes, immune deficiency, chronic kidney disease, neuromuscular disease, and malignancy.\r\n\r\nThis study confirms the increased severity of disease in critically ill men with COVID-19, even in a long-term perspective. However, mortality beyond 90 days was strikingly low, indicating high probability of survival after the acute phase of illness.", "doi": "10.1186/s13613-023-01156-3", "pmid": "37642833", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC10465451"}, {"db": "pii", "key": "10.1186/s13613-023-01156-3"}], "notes": [], "created": "2023-10-05T08:08:34.880Z", "modified": "2023-10-05T08:54:18.433Z"}, {"entity": "publication", "iuid": "4915a33bdda740cda0a5c21e21012377", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4915a33bdda740cda0a5c21e21012377.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4915a33bdda740cda0a5c21e21012377"}}, "title": "Impact of Risk Factors on COVID-19 Outcomes in Unvaccinated People with Rheumatic Diseases.", "authors": [{"family": "Yazdany", "given": "Jinoos", "initials": "J", "orcid": "0000-0002-3508-4094", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62bbeb3392ce40d482da768af63f5d54.json"}}, {"family": "Ware", "given": "Anna", "initials": "A", "orcid": "0000-0003-3333-7833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6be3cbe46a3b4190a31e190c195f7e77.json"}}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Grainger", "given": "Rebecca", "initials": "R", "orcid": "0000-0001-9201-8678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9d304e9e29a43a5a7a76679c002a876.json"}}, {"family": "Hachulla", "given": "Eric", "initials": "E"}, {"family": "Richez", "given": "Christophe", "initials": "C"}, {"family": "Cacoub", "given": "Patrice", "initials": "P", "orcid": "0000-0002-6727-4992", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fc3b4f8d7994a7fb48f3facfa27baf8.json"}}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS", "orcid": "0000-0003-0786-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d99dc166f48d4af7b8e46dc999c7444b.json"}}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Jacobsohn", "given": "Lindsay", "initials": "L"}, {"family": "Strangfeld", "given": "Anja", "initials": "A"}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL"}, {"family": "Gossec", "given": "Laure", "initials": "L"}, {"family": "Carmona", "given": "Loreto", "initials": "L"}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S", "orcid": "0000-0002-8611-162X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73b17eb08d984421847f733b7a6a49d4.json"}}, {"family": "Kearsley-Fleet", "given": "Lianne", "initials": "L", "orcid": "0000-0003-0377-1575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9cc64aac266462baf67998b3d49c6f7.json"}}, {"family": "Schaefer", "given": "Martin", "initials": "M", "orcid": "0000-0001-6487-3634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb2c617a7902440eb574fcb1141785ac.json"}}, {"family": "Ribeiro", "given": "Sandra Lucia Euzebio", "initials": "SLE", "orcid": "0000-0002-4777-8659", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2db6a09138844b1690855b8b44af31ec.json"}}, {"family": "Al-Emadi", "given": "Samar", "initials": "S", "orcid": "0000-0001-7942-4831", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49a627d387d042f7b99d821d9676d0d5.json"}}, {"family": "Hasseli", "given": "Rebecca", "initials": "R"}, {"family": "M\u00fcller-Ladner", "given": "Ulf", "initials": "U"}, {"family": "Specker", "given": "Christof", "initials": "C"}, {"family": "Schulze-Koops", "given": "Hendrik", "initials": "H"}, {"family": "Bernardes", "given": "Miguel", "initials": "M"}, {"family": "Machado Fraga", "given": "Vanessa", "initials": "V"}, {"family": "Rodrigues", "given": "Ana Maria", "initials": "AM"}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA", "orcid": "0000-0002-5556-4618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/192552e5e3d2435799e57111ea84502d.json"}}, {"family": "Ljung", "given": "Lotta", "initials": "L"}, {"family": "Di Giuseppe", "given": "Daniela", "initials": "D"}, {"family": "Tidblad", "given": "Liselotte", "initials": "L"}, {"family": "Wise", "given": "Leanna", "initials": "L", "orcid": "0000-0002-6172-9474", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a7e415e8715491bb9d0409d4b008443.json"}}, {"family": "Duarte-Garc\u00eda", "given": "Al\u00ed", "initials": "A", "orcid": "0000-0003-1749-5719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77a5555c1b624ba49ee7c729be2aef95.json"}}, {"family": "Ugarte-Gil", "given": "Manuel F", "initials": "MF", "orcid": "0000-0003-1728-1999", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b49a52ac208747ed9b85f286119da620.json"}}, {"family": "Colunga-Pedraza", "given": "Iris Jazm\u00edn", "initials": "IJ", "orcid": "0000-0002-2786-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50e46ef2c7f44b39a1d28fea6a8e621d.json"}}, {"family": "Mart\u00ednez-Mart\u00ednez", "given": "Marco Ulises", "initials": "MU"}, {"family": "Alpizar-Rodriguez", "given": "Deshire", "initials": "D"}, {"family": "Xavier", "given": "Ricardo Machado", "initials": "RM"}, {"family": "Isnardi", "given": "Carolina A", "initials": "CA"}, {"family": "Pera", "given": "Mariana", "initials": "M"}, {"family": "Pons-Estel", "given": "Guillermo", "initials": "G"}, {"family": "Izadi", "given": "Zara", "initials": "Z"}, {"family": "Gianfrancesco", "given": "Milena A", "initials": "MA", "orcid": "0000-0002-8351-4626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dca9cada1314065ab094be6fc17524e.json"}}, {"family": "Carrara", "given": "Greta", "initials": "G"}, {"family": "Scir\u00e8", "given": "Carlo Alberto", "initials": "CA", "orcid": "0000-0001-7451-0271", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76ebc6c1acb94b2780a38dc4e8aea708.json"}}, {"family": "Zanetti", "given": "Anna", "initials": "A"}, {"family": "Machado", "given": "Pedro M", "initials": "PM", "orcid": "0000-0002-8411-7972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef40d1eea57946e4a37d2e92a02a47cd.json"}}], "type": "journal article", "published": "2023-08-29", "journal": {"title": "Arthritis Care Res (Hoboken)", "issn": "2151-4658", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Approximately one-third of individuals worldwide have not received a COVID-19 vaccine. While studies have investigated risk factors linked to severe COVID-19 among unvaccinated people with rheumatic diseases(RD), we know less about whether these factors changed as the pandemic progressed. We aimed to identify risk factors associated with severe COVID-19 in unvaccinated individuals in different pandemic epochs corresponding to major variants of concern.\r\n\r\nPatients with RD and COVID-19 were entered into the COVID-19 Global Rheumatology Alliance registry between March 2020 and June 2022. An ordinal logistic regression model (not hospitalized, hospitalized, and death) was used with date of COVID-19 diagnosis, age, sex, race and/or ethnicity, comorbidities, RD activity, medications, and the human development index(HDI) as covariates. The main analysis included all unvaccinated patients across COVID-19 pandemic epochs; sub-analyses stratified patients according to rheumatic disease types.\r\n\r\nAmong 19,256 unvaccinated people with RD and COVID-19, those who were older, male, had more comorbidities, used glucocorticoids, had higher disease activity, or lived in lower HDI regions had worse outcomes across epochs. For those with rheumatoid arthritis, sulfasalazine and B-cell depleting therapy were associated with worse outcomes, and TNF-inhibitors were associated with improved outcomes. In those with connective tissue disease or vasculitis, B-cell depleting therapy was associated with worse outcomes.\r\n\r\nRisk factors for severe COVID-19 outcomes were similar throughout pandemic epochs in unvaccinated people with RD. Ongoing efforts, including vaccination, are needed to reduce COVID-19 severity in this population, particularly in those with medical and social vulnerabilities identified in this study. This article is protected by copyright. All rights reserved.", "doi": "10.1002/acr.25220", "pmid": "37643903", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:08:47.001Z", "modified": "2023-10-06T04:36:31.468Z"}, {"entity": "publication", "iuid": "2c3ccb5cc8be45aebd39a89e3bf7627c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c3ccb5cc8be45aebd39a89e3bf7627c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c3ccb5cc8be45aebd39a89e3bf7627c"}}, "title": "Alterations in the gut microbiome and its metabolites are associated with the immune response to mucosal immunization with Lactiplantibacillus plantarum-displaying recombinant SARS-CoV-2 spike epitopes in mice.", "authors": [{"family": "Hwang", "given": "In-Chan", "initials": "I"}, {"family": "Vasquez", "given": "Robie", "initials": "R"}, {"family": "Song", "given": "Ji Hoon", "initials": "JH"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Valeriano", "given": "Valerie Diane", "initials": "VD"}, {"family": "Kang", "given": "Dae-Kyung", "initials": "D"}], "type": "journal article", "published": "2023-08-29", "journal": {"title": "Front Cell Infect Microbiol", "issn": "2235-2988", "issn-l": null, "volume": "13", "issue": null, "pages": "1242681"}, "abstract": "Lactic acid bacteria (LAB) expressing foreign antigens have great potential as mucosal vaccines. Our previous study reported that recombinant Lactiplantibacillus plantarum SK156 displaying SARS-CoV-2 spike S1 epitopes elicited humoral and cell-mediated immune responses in mice. Here, we further examined the effect of the LAB-based mucosal vaccine on gut microbiome composition and function, and gut microbiota-derived metabolites. Forty-nine (49) female BALB/c mice were orally administered L. plantarum SK156-displaying SARS-CoV-2 spike S1 epitopes thrice (at 14-day intervals). Mucosal immunization considerably altered the gut microbiome of mice by enriching the abundance of beneficial gut bacteria, such as Muribaculaceae, Mucispirillum, Ruminococcaceae, Alistipes, Roseburia, and Clostridia vadinBB60. Moreover, the predicted function of the gut microbiome showed increased metabolic pathways for amino acids, energy, carbohydrates, cofactors, and vitamins. The fecal concentration of short-chain fatty acids, especially butyrate, was also altered by mucosal immunization. Notably, alterations in gut microbiome composition, function, and butyrate levels were positively associated with the immune response to the vaccine. Our results suggest that the gut microbiome and its metabolites may have influenced the immunogenicity of the LAB-based SARS-CoV-2 vaccine.", "doi": "10.3389/fcimb.2023.1242681", "pmid": "37705931", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10495993"}], "notes": [], "created": "2023-10-06T06:57:13.128Z", "modified": "2023-10-09T06:22:09.264Z"}, {"entity": "publication", "iuid": "acab9062e3cb4dd9b5570dcc70e685b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/acab9062e3cb4dd9b5570dcc70e685b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/acab9062e3cb4dd9b5570dcc70e685b3"}}, "title": "Quality of life of COVID-19 recovered patients: a 1-year follow-up study from Bangladesh.", "authors": [{"family": "Hawlader", "given": "Mohammad Delwer Hossain", "initials": "MDH"}, {"family": "Rashid", "given": "Md Utba", "initials": "MU"}, {"family": "Khan", "given": "Md Abdullah Saeed", "initials": "MAS"}, {"family": "Liza", "given": "Mowshomi Mannan", "initials": "MM"}, {"family": "Akter", "given": "Sharmin", "initials": "S"}, {"family": "Hossain", "given": "Mohammad Ali", "initials": "MA"}, {"family": "Rahman", "given": "Tajrin", "initials": "T"}, {"family": "Barsha", "given": "Sabrina Yesmin", "initials": "SY"}, {"family": "Shifat", "given": "Alberi Afifa", "initials": "AA"}, {"family": "Hossian", "given": "Mosharop", "initials": "M"}, {"family": "Mishu", "given": "Tahmina Zerin", "initials": "TZ"}, {"family": "Sagar", "given": "Soumik Kha", "initials": "SK"}, {"family": "Manna", "given": "Ridwana Maher", "initials": "RM"}, {"family": "Ahmed", "given": "Nawshin", "initials": "N"}, {"family": "Debu", "given": "Sree Shib Shankar Devnath", "initials": "SSSD"}, {"family": "Chowdhury", "given": "Irin", "initials": "I"}, {"family": "Sabed", "given": "Samanta", "initials": "S"}, {"family": "Ahmed", "given": "Mashrur", "initials": "M"}, {"family": "Borsha", "given": "Sabrina Afroz", "initials": "SA"}, {"family": "Al Zafar", "given": "Faraz", "initials": "F"}, {"family": "Hyder", "given": "Sabiha", "initials": "S"}, {"family": "Enam", "given": "Abdullah", "initials": "A"}, {"family": "Babul", "given": "Habiba", "initials": "H"}, {"family": "Nur", "given": "Naima", "initials": "N"}, {"family": "Haque", "given": "Miah Md Akiful", "initials": "MMA"}, {"family": "Roy", "given": "Shopnil", "initials": "S"}, {"family": "Tanvir Hassan", "given": "K M", "initials": "KM"}, {"family": "Rahman", "given": "Mohammad Lutfor", "initials": "ML"}, {"family": "Nabi", "given": "Mohammad Hayatun", "initials": "MH"}, {"family": "Dalal", "given": "Koustuv", "initials": "K", "orcid": "0000-0001-7393-796X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab5e44a17b7545988cb46cdf5b1f3e4e.json"}}], "type": "journal article", "published": "2023-08-25", "journal": {"title": "Infect Dis Poverty", "issn": "2049-9957", "issn-l": null, "volume": "12", "issue": "1", "pages": "79"}, "abstract": "The COVID-19 pandemic posed a danger to global public health because of the unprecedented physical, mental, social, and environmental impact affecting quality of life (QoL). The study aimed to find the changes in QoL among COVID-19 recovered individuals and explore the determinants of change more than 1 year after recovery in low-resource settings.\r\n\r\nCOVID-19 patients from all eight divisions of Bangladesh who were confirmed positive by reverse transcription-polymerase chain reaction from June 2020 to November 2020 and who subsequently recovered were followed up twice, once immediately after recovery and again 1 year after the first follow-up. The follow-up study was conducted from November 2021 to January 2022 among 2438 individuals using the World Health Organization Quality of Life Brief Version (WHOQOL-BREF). After excluding 48 deaths, 95 were rejected to participate, 618 were inaccessible, and there were 45 cases of incomplete data. Descriptive statistics, paired-sample analyses, generalized estimating equation (GEE) analysis, and multivariable logistic regression analyses were performed to test the mean difference in participants' QoL scores between the two interviews.\r\n\r\nMost participants (n = 1710, 70.1%) were male, and one-fourth (24.4%) were older than 46. The average physical domain score decreased significantly from baseline to follow-up, and the average scores in psychological, social, and environmental domains increased significantly at follow-up (P < 0.05). By the GEE equation approach, after adjusting for other factors, we found that older age groups (P < 0.001), being female (P < 0.001), having hospital admission during COVID-19 illness (P < 0.001), and having three or more chronic diseases (P < 0.001), were significantly associated with lower physical and psychological QoL scores. Higher age and female sex [adjusted odd ratio (aOR) = 1.3, 95% confidence interval (CI) 1.0-1.6] were associated with reduced social domain scores on multivariable logistic regression analysis. Urban or semi-urban people were 49% less likely (aOR = 0.5, 95% CI 0.4-0.7) and 32% less likely (aOR = 0.7, 95% CI 0.5-0.9) to have a reduced QoL score in the psychological domain and the social domain respectively, than rural people. Higher-income people were more likely to experience a decrease in QoL scores in physical, psychological, social, and environmental domains. Married people were 1.8 times more likely (aOR = 1.8, 95% CI 1.3-2.4) to have a decreased social QoL score. In the second interview, people admitted to hospitals during their COVID-19 infection showed a 1.3 times higher chance (aOR = 1.3, 95% CI 1.1-1.6) of a decreased environmental QoL score. Almost 13% of participants developed one or more chronic diseases between the first and second interviews. Moreover, 7.9% suffered from reinfection by COVID-19 during this 1-year time.\r\n\r\nThe present study found that the QoL of COVID-19 recovered people improved 1 year after recovery, particularly in psychological, social, and environmental domains. However, age, sex, the severity of COVID-19, smoking habits, and comorbidities were significantly negatively associated with QoL. Events of reinfection and the emergence of chronic disease were independent determinants of the decline in QoL scores in psychological, social, and physical domains, respectively. Strong policies to prevent and minimize smoking must be implemented in Bangladesh, and we must monitor and manage chronic diseases in people who have recovered from COVID-19.", "doi": "10.1186/s40249-023-01125-9", "pmid": "37626363", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10463646"}, {"db": "pii", "key": "10.1186/s40249-023-01125-9"}], "notes": [], "created": "2023-10-05T08:08:51.924Z", "modified": "2023-10-06T04:39:17.151Z"}, {"entity": "publication", "iuid": "ae50d23c447b4196954c31aa1bdc0fb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ae50d23c447b4196954c31aa1bdc0fb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ae50d23c447b4196954c31aa1bdc0fb1"}}, "title": "Bayesian monitoring of COVID-19 in Sweden.", "authors": [{"family": "Marin", "given": "Robin", "initials": "R"}, {"family": "Runvik", "given": "H\u00e5kan", "initials": "H"}, {"family": "Medvedev", "given": "Alexander", "initials": "A"}, {"family": "Engblom", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2023-08-24", "journal": {"title": "Epidemics", "issn": "1878-0067", "issn-l": null, "volume": "45", "issue": null, "pages": "100715"}, "abstract": "In an effort to provide regional decision support for the public healthcare, we design a data-driven compartment-based model of COVID-19 in Sweden. From national hospital statistics we derive parameter priors, and we develop linear filtering techniques to drive the simulations given data in the form of daily healthcare demands. We additionally propose a posterior marginal estimator which provides for an improved temporal resolution of the reproduction number estimate as well as supports robustness checks via a parametric bootstrap procedure. From our computational approach we obtain a Bayesian model of predictive value which provides important insight into the progression of the disease, including estimates of the effective reproduction number, the infection fatality rate, and the regional-level immunity. We successfully validate our posterior model against several different sources, including outputs from extensive screening programs. Since our required data in comparison is easy and non-sensitive to collect, we argue that our approach is particularly promising as a tool to support monitoring and decisions within public health. Significance: Using public data from Swedish patient registries we develop a national-scale computational model of COVID-19. The parametrized model produces valuable weekly predictions of healthcare demands at the regional level and validates well against several different sources. We also obtain critical epidemiological insights into the disease progression, including, e.g., reproduction number, immunity and disease fatality estimates. The success of the model hinges on our novel use of filtering techniques which allows us to design an accurate data-driven procedure using data exclusively from healthcare demands, i.e., our approach does not rely on public testing and is therefore very cost-effective.", "doi": "10.1016/j.epidem.2023.100715", "pmid": "37703786", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Other": null, "Funder: Vinnova": null}, "xrefs": [{"db": "pii", "key": "S1755-4365(23)00051-8"}], "notes": [], "created": "2023-10-04T12:10:33.906Z", "modified": "2023-10-06T11:35:30.320Z"}, {"entity": "publication", "iuid": "1f0f46e03164417b85380701e798b5a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1f0f46e03164417b85380701e798b5a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1f0f46e03164417b85380701e798b5a9"}}, "title": "Efficacy of Kan Jang\u00ae in Patients with Mild COVID-19: A Randomized, Quadruple-Blind, Placebo-Controlled Trial.", "authors": [{"family": "Ratiani", "given": "Levan", "initials": "L"}, {"family": "Pachkoria", "given": "Elene", "initials": "E"}, {"family": "Mamageishvili", "given": "Nato", "initials": "N"}, {"family": "Shengelia", "given": "Ramaz", "initials": "R"}, {"family": "Hovhannisyan", "given": "Areg", "initials": "A"}, {"family": "Panossian", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8467-4525", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86a40ce1842b4c289c7f09c955ad4325.json"}}], "type": "journal article", "published": "2023-08-22", "journal": {"title": "Pharmaceuticals (Basel)", "issn": "1424-8247", "issn-l": null, "volume": "16", "issue": "9", "pages": null}, "abstract": ". This study aimed to assess the efficacy of the treatment of Kan JangBackground and aim\u00ae, a fixed combination of Andrographis paniculata (Burm. F.) Wall. ex. Nees and Eleutherococcus senticosus (Rupr. & Maxim.) Maxim extracts in patients with mild symptoms of COVID-19. . One hundred and forty patients received six capsules of Kan JangMethods\u00ae (n = 68, daily dose of andrographolides-90 mg) or placebo (n = 72) and supportive treatment (paracetamol) for 14 consecutive days in a randomized, quadruple-blinded, placebo-controlled, two-parallel-group design. The efficacy outcomes were the rate of cases turning to severe, the detection rate of coronavirus SARS-CoV-2 over the time of treatment, the duration, and the severity of symptoms (sore throat, runny nose, cough, headache, fatigue, loss of smell, taste, pain in muscles) in the acute phase of the disease. Other efficacy measures included improving cognitive and physical performance, quality of life, and the levels of inflammatory blood markers-interleukin 6 (IL-6), C-reactive protein, and D-dimer. . Kan JangResults\u00ae significantly (p < 0.05) reduced the rate of cases turning to severe (5.36%) compared to the placebo (17.86%) and decreased the detection rate of SARS-CoV-2 virus over the time of the treatment. The statistical difference in the rates of patients with clinical deterioration in the Kan Jang treatment and placebo control groups was significant (p = 0.0176) both in the 112 patients in the included-per-protocol (IPP) analysis and in the 140 patients in the intended-to-treat (ITT) analysis (p = 0.0236); the absolute risk reduction in cases thanks to the Kan Jang treatment was 12.5%, and the number we needed to treat with Kan Jang was 8. The patient's recovery time (number of sick days at the home/clinic) was shorter in the Kan Jang group compared with the placebo group. The rate of attenuation of inflammatory symptoms in the Kan Jang\u00ae group was significantly higher, decreasing the severity of cough, sore throat/pain, runny nose, and muscle soreness compared with the placebo group. Kan Jang\u00ae significantly decreased the Wisconsin Upper Respiratory Symptoms scores compared to the placebo in the sample size of 140 patients. However, the relief of fatigue and headache and the decrease in IL-6 in the blood were observed only in a subset of 86 patients infected during the second three waves of the pandemic. Kan Jang\u00ae significantly increased physical activity and workout; however, it did not affect cognitive functions (attention and memory), quality of life score, inflammatory marker D-dimer, and C-reactive protein compared with the placebo group. . Overall, the results of this study suggest that Kan JangConclusions\u00ae is effective in treating mild and moderate COVID-19 irrespective of the SARS-CoV-2 variant of infection.", "doi": "10.3390/ph16091196", "pmid": "37765004", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10535596"}, {"db": "pii", "key": "ph16091196"}], "notes": [], "created": "2023-10-06T06:55:26.233Z", "modified": "2023-10-06T10:53:37.475Z"}, {"entity": "publication", "iuid": "24216cd75b2047d8a66e2d97d42d7563", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24216cd75b2047d8a66e2d97d42d7563.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24216cd75b2047d8a66e2d97d42d7563"}}, "title": "Person-centred care in nursing homes during the COVID-19 pandemic: a cross sectional study based on nursing staff and first-line managers' self-reported outcomes.", "authors": [{"family": "Lindner", "given": "Helen", "initials": "H"}, {"family": "Kihlgren", "given": "Annica", "initials": "A"}, {"family": "Pejner", "given": "Margaretha Norell", "initials": "MN"}], "type": "journal article", "published": "2023-08-21", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "issn-l": null, "volume": "22", "issue": "1", "pages": "276"}, "abstract": "COVID-19 has presented many difficulties in providing person-centred care (PCC) in nursing homes (NH). Factors such as organisational support, work condition and leadership may play a crucial role in supporting the performance of PCC during COVID restrictions. The study aim was to evaluate nursing staff and manager perceptions of the opportunities to perform person-centred care during the COVID-19 pandemic.\r\n\r\nNursing staff (NS) (n = 463) and First Line Managers (FLM) (n = 8) within all NHs in one community filled in the SVENIS questionnaire which consists of five areas: perceived organizational support, work climate, person-centred care, work conditions and leadership. A Kruskal-Wallis test was used to perform inter-group comparisons and standard multiple regression was used to investigate which factor contributed most to perform PCC.\r\n\r\nThe comparison analyses indicate that staff from nursing homes for persons with dementia had the highest opportunities to perform PCC during the pandemic. The day shift staff had more opportunities to perform PCC than night shift staff. The results from the standard multiple regression show that a NA's current nursing home was the most significant variable affecting the opportunities to perform PCC. The analyses of both the comparison analyses and the regression suggest that day shift staff from nursing homes for persons with dementia had the highest opportunities to perform PCC during the pandemic. The same group also rated the importance of leadership as high for performing PCC.\r\n\r\nDespite the COVID-19 restrictions and all the criticism directed against the care of older people; the day staff felt that they conducted PCC. Staff in nursing homes for dementia had the highest opportunities for PCC and this may be because they are better prepared to provide care for the individual in NH. The importance of leadership was also evident, which means that investment in FLMs is seen as necessary.", "doi": "10.1186/s12912-023-01437-z", "pmid": "37605177", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10440872"}, {"db": "pii", "key": "10.1186/s12912-023-01437-z"}], "notes": [], "created": "2023-10-05T08:08:54.351Z", "modified": "2023-10-06T04:40:25.696Z"}, {"entity": "publication", "iuid": "7ca4bd5cc52d4aed97bf6158b63fc396", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7ca4bd5cc52d4aed97bf6158b63fc396.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7ca4bd5cc52d4aed97bf6158b63fc396"}}, "title": "Early Onset Delirium During Hospitalization Increases In-Hospital and Postdischarge Mortality in COVID-19 Patients: A Multicenter Prospective Study.", "authors": [{"family": "Trevisan", "given": "Caterina", "initials": "C"}, {"family": "Grande", "given": "Giulia", "initials": "G"}, {"family": "Rebora", "given": "Paola", "initials": "P"}, {"family": "Zucchelli", "given": "Alberto", "initials": "A"}, {"family": "Valsecchi", "given": "Maria Grazia", "initials": "MG"}, {"family": "Foc\u00e0", "given": "Emanuele", "initials": "E"}, {"family": "Ecarnot", "given": "Fiona", "initials": "F"}, {"family": "Marengoni", "given": "Alessandra", "initials": "A"}, {"family": "Bellelli", "given": "Giuseppe", "initials": "G"}], "type": "multicenter study", "published": "2023-08-21", "journal": {"title": "J Clin Psychiatry", "issn": "1555-2101", "issn-l": null, "volume": "84", "issue": "5", "pages": null}, "abstract": "Delirium is a common feature in COVID-19 patients. Although its association with in-hospital mortality has previously been reported, data concerning postdischarge mortality and delirium subtypes are scarce. We evaluated the association between delirium and its subtypes and both in-hospital and postdischarge mortality. Objective: This multicenter longitudinal clinical-based study was conducted in Monza and Brescia, Italy. The study population included 1,324 patients (median age: 68 years) with COVID-19 admitted to 4 acute clinical wards in northern Italy during the first pandemic waves (February 2020 to January 2021). Delirium within 48 hours of hospital admission was assessed through validated scores and/or clinically according to Methods:DSM-5 criteria. The association of delirium-and its subtypes-with in-hospital and postdischarge mortality (over a median observation period of 257 [interquartile range: 189-410] days) was evaluated through Cox proportional hazards models. The 223 patients (16.8%) presenting delirium had around 2-fold increased in-hospital (hazard ratio [HR] = 1.94; 95% CI, 1.38-2.73) and postdischarge (HR = 2.01; 95% CI, 1.48-2.73) mortality than those without delirium. All delirium subtypes were associated with greater risk of death compared to the absence of delirium, but hypoactive delirium revealed the strongest associations with both in-hospital (HR = 2.03; 95% CI, 1.32-3.13) and postdischarge (HR = 2.22; 95% CI, 1.52-3.26) mortality. Results: In patients with COVID-19, early onset delirium is associated not only with in-hospital mortality but also with shorter postdischarge survival. This suggests that delirium detection and management are crucial to improving the prognosis of COVID-19 patients. Conclusions: ClinicalTrials.gov identifier: NCT04412265.Trial Registration:", "doi": "10.4088/JCP.22m14565", "pmid": "37616485", "labels": {"Category: Health": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "22m14565"}, {"db": "ClinicalTrials.gov", "key": "NCT04412265"}], "notes": [], "created": "2023-10-05T08:26:04.491Z", "modified": "2023-10-06T04:45:08.102Z"}, {"entity": "publication", "iuid": "ec5bd7a61fa74750ba0036e4f5db58e4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec5bd7a61fa74750ba0036e4f5db58e4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec5bd7a61fa74750ba0036e4f5db58e4"}}, "title": "Did the COVID-19 pandemic influence inequality in self-reported work environment conditions based on gender and place of birth? A study of a Swedish commercial laundromat.", "authors": [{"family": "Januario", "given": "Leticia Bergamin", "initials": "LB"}, {"family": "Mathiassen", "given": "Svend Erik", "initials": "SE"}, {"family": "Bergstr\u00f6m", "given": "Gunnar", "initials": "G"}, {"family": "Jackson", "given": "Jennie A", "initials": "JA"}], "type": "journal article", "published": "2023-08-21", "journal": {"title": "Appl Ergon", "issn": "1872-9126", "issn-l": null, "volume": "114", "issue": null, "pages": "104113"}, "abstract": "We evaluated differences in work environment conditions and health by gender and place of birth in a commercial laundromat prior to (baseline) and at the end of the first wave of the COVID-19 pandemic (follow-up). Using survey data, including dimensions from the Copenhagen Psychosocial Questionnaire, from forty-one workers, we assessed work environment conditions and health at baseline, follow-up and in change scores between baseline and follow-up. At baseline, men and women reported similar scores, while foreign-born (FB) workers reported better work environment conditions than Swedish-born (SB) workers. During the pandemic, conditions generally declined for all workers, but FB reported smaller declines than SB. A consistent inequality hierarchy across the 4 groups was not clear at baseline, follow-up or in change scores between time points. The study suggests potential cultural differences may exist in how work environment conditions are experienced. This should be considered in future studies and when managing future crises.", "doi": "10.1016/j.apergo.2023.104113", "pmid": "37611535", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0003-6870(23)00151-5"}], "notes": [], "created": "2023-10-05T08:26:35.912Z", "modified": "2023-10-06T05:00:50.941Z"}, {"entity": "publication", "iuid": "3aac4306641a4a01bb31154e6c7616cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3aac4306641a4a01bb31154e6c7616cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3aac4306641a4a01bb31154e6c7616cb"}}, "title": "Two cases of nursing older nursing home residents during COVID-19.", "authors": [{"family": "Jaarsma", "given": "Pier", "initials": "P", "orcid": "0000-0003-4429-2853", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91b16416951a4b2a831961d5e9a7a6d1.json"}}, {"family": "Gelhaus", "given": "Petra", "initials": "P"}, {"family": "Eklund Saksberg", "given": "My", "initials": "M"}], "type": "journal article", "published": "2023-08-19", "journal": {"title": "Nurs Ethics", "issn": "1477-0989", "issn-l": null, "volume": null, "issue": null, "pages": "9697330231185944"}, "abstract": "Two ethical challenges of nursing home nurses during the COVID-19 pandemic in Sweden are discussed in this paper.\r\n\r\nHistorically, the nurse's primary concern is for the person who is ill, which is the core of nurses' moral responsibility and identity. In Sweden, person-centered care is generally deemed important in nursing older nursing home residents.\r\n\r\nTo chart moral responsibilities of nursing home nurses in two cases involving older residents during the COVID-19 pandemic in Sweden.\r\n\r\nWe used Margaret Urban Walker's framework for moral responsibilities and the International Council of Nurses (ICN) code of ethics for nurses (2021) for our normative analysis.\r\n\r\nWritten and verbal consent was obtained before the interviews, and information was given that participation was entirely voluntary and possible to cancel at any time before the work was published. The Swedish Ethical Review Agency gave an advisory opinion stating that there were no ethical objections to this research project (Dnr. 2020-05649).\r\n\r\nCase #1: a palliative older nursing home resident who was coercively tested for COVID-19, and case #2: a COVID-19-infected resident with dementia who was isolated using sedation. The decision that was finally made in the respective case was analyzed in the light of either consequentialist/utilitarian or non-consequentialist/deontological reasons.\r\n\r\nEmpowerment of nurses as moral agents is required for the application of practical wisdom in the balancing of different care relationships (responsibilities), moral identities (professional virtues), and competing moral values. This requires resources and opens possibilities for profound ethical reflection in nursing education and at work.\r\n\r\nDuring the COVID-19 pandemic, the moral and professional responsibility of nursing home nurses to deliver person-centered care was sometimes problematically abandoned in favor of a more utilitarian manner of ethical decision-making.", "doi": "10.1177/09697330231185944", "pmid": "37597000", "labels": {"Funder: Forte": null, "Type: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:08:37.400Z", "modified": "2023-10-05T08:55:22.474Z"}, {"entity": "publication", "iuid": "4ed3677531104d9392850a68bffd903f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ed3677531104d9392850a68bffd903f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ed3677531104d9392850a68bffd903f"}}, "title": "Risk and outcomes of COVID-19 in patients with oxygen-dependent chronic respiratory failure- a national cohort study.", "authors": [{"family": "Sundh", "given": "Josefin", "initials": "J"}, {"family": "Palm", "given": "Andreas", "initials": "A"}, {"family": "Ljunggren", "given": "Mirjam", "initials": "M"}, {"family": "Emilsson", "given": "\u00d6ssur Ingi", "initials": "\u00d6I"}, {"family": "Grote", "given": "Ludger", "initials": "L"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ekstr\u00f6m", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2023-08-19", "journal": {"title": "Respir Med", "issn": "1532-3064", "issn-l": "0954-6111", "volume": "218", "issue": null, "pages": "107392"}, "abstract": "We aimed to evaluate cumulative occurrence and impact of COVID-19 in patients with chronic respiratory failure (CRF) treated with long-term oxygen therapy (LTOT).\r\n\r\nData were obtained from the SCIFI-PEARL study on the entire Swedish population and on patients with oxygen-dependent CRF and no COVID-19 diagnosis before start of LTOT. Analyses were performed for three time periods; pre-alpha (Jan-Dec 2020), alpha (Jan-Mar 2021) and delta/omicron (Apr 2021-May 2022). Cumulative incidence of laboratory-verified COVID-19 was compared between patients with CRF and the general population. Risk factors for severe (hospitalised) to critical (intensive care, or death \u226430 days after infection) COVID-19, and the impact of COVID-19 on one-year mortality, were analysed using multivariable Cox regression.\r\n\r\nCumulative incidence of COVID-19 was higher in patients with CRF than in the general population during the pre-alpha period (6.4%/4.9%, p = 0.002), but less common during the alpha and delta/omicron periods (2.9%/3.8% and 7.8%/15.5%, p < 0.0001 for both). The risk of severe/critical COVID-19 was much higher in CRF patients during all periods (4.9%/0.5%, 3.8%/0.2% and 15.5%/0.5%, p < 0.0001 for all). Risk factors for COVID-19 infection in people with CRF were higher age, cardiovascular and renal disease, and COVID-19 was associated with increased one-year mortality following infection in the pre-alpha (HR 1.79; [95% CI] 1.27-2.53) and alpha periods (1.43; 1.03-1.99).\r\n\r\nPatients with CRF had higher risk of severe/critical COVID-19 than the general population. COVID-19 infection was associated with excess one-year mortality.", "doi": "10.1016/j.rmed.2023.107392", "pmid": "37598894", "labels": {"Category: Health": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pii", "key": "S0954-6111(23)00280-9"}], "notes": [], "created": "2023-10-05T08:02:26.196Z", "modified": "2023-10-05T08:42:32.803Z"}, {"entity": "publication", "iuid": "3e633c6a7f7043679e7d6028c9f85f40", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3e633c6a7f7043679e7d6028c9f85f40.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3e633c6a7f7043679e7d6028c9f85f40"}}, "title": "Variations across Europe in hospitalization and management of pregnant women with SARS-CoV-2 during the initial phase of the pandemic: Multi-national population-based cohort study using the International Network of Obstetric Survey Systems (INOSS).", "authors": [{"family": "de Bruin", "given": "Odette", "initials": "O", "orcid": "0000-0001-6295-3411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cb1846613dd40b0a620d3b57bdf7012.json"}}, {"family": "Engjom", "given": "Hilde", "initials": "H", "orcid": "0000-0003-1582-4283", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c252a103177f4a12a560a5fa1a02941a.json"}}, {"family": "Vousden", "given": "Nicola", "initials": "N"}, {"family": "Ramakrishnan", "given": "Rema", "initials": "R"}, {"family": "Aabakke", "given": "Anna J M", "initials": "AJM", "orcid": "0000-0003-4754-506X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c142bd2b1fc84a7e864d2af58096bcaf.json"}}, {"family": "\u00c4yr\u00e4s", "given": "Outi", "initials": "O", "orcid": "0000-0002-2423-611X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45245d469a6a4629bb3197f51be274bf.json"}}, {"family": "Donati", "given": "Serena", "initials": "S", "orcid": "0000-0002-4607-2072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52c96021dc5f4d41a7098cd3b5815649.json"}}, {"family": "J\u00f3nasd\u00f3ttir", "given": "Eva", "initials": "E"}, {"family": "Knight", "given": "Marian", "initials": "M", "orcid": "0000-0002-1984-4575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c2039d5a7904bb2b86fcc9288b1c4fa.json"}}, {"family": "Overtoom", "given": "Evelien M", "initials": "EM", "orcid": "0000-0001-6454-4531", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd001d702fe0494ebe68a0d0b4dae739.json"}}, {"family": "Salvatore", "given": "Michele A", "initials": "MA"}, {"family": "Sturkenboom", "given": "Miriam C J M", "initials": "MCJM"}, {"family": "Svanvik", "given": "Teresia", "initials": "T", "orcid": "0000-0003-1947-679X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5c912ccb32524c468a81dd35f17f10cb.json"}}, {"family": "Varpula", "given": "Reetta", "initials": "R"}, {"family": "Vercoutere", "given": "An", "initials": "A"}, {"family": "Bloemenkamp", "given": "Kitty W M", "initials": "KWM", "orcid": "0000-0002-1377-4625", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6fc16703b53043369e998576c3e74737.json"}}, {"family": "INOSS COVID-19 Working Group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-08-18", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "issn-l": "0001-6349", "volume": null, "issue": null, "pages": null}, "abstract": "The majority of data on COVID-19 in pregnancy are not from sound population-based active surveillance systems.\r\n\r\nWe conducted a multi-national study of population-based national or regional prospective cohorts using standardized definitions within the International Network of Obstetric Survey systems (INOSS). From a source population of women giving birth between March 1 and August 31, 2020, we included pregnant women admitted to hospital with a positive SARS-CoV-2 PCR test \u22647 days prior to or during admission and up to 2 days after birth. The admissions were further categorized as COVID-19-related or non-COVID-19-related. The primary outcome of interest was incidence of COVID-19-related hospital admission. Secondary outcomes included severe maternal disease (ICU admission and mechanical ventilation) and COVID-19-directed medical treatment.\r\n\r\nIn a source population of 816 628 maternities, a total of 2338 pregnant women were admitted with SARS-CoV-2; among them 940 (40%) were COVID-19-related admissions. The pooled incidence estimate for COVID-19-related admission was 0.59 (95% confidence interval 0.27-1.02) per 1000 maternities, with notable heterogeneity across countries (I2 = 97.3%, P = 0.00). In the COVID-19 admission group, between 8% and 17% of the women were admitted to intensive care, and 5%-13% needed mechanical ventilation. Thromboprophylaxis was the most frequent treatment given during COVID-19-related admission (range 14%-55%). Among 908 infants born to women in the COVID-19-related admission group, 5 (0.6%) stillbirths were reported.\r\n\r\nDuring the initial months of the pandemic, we found substantial variations in incidence of COVID-19-related admissions in nine European countries. Few pregnant women received COVID-19-directed medical treatment. Several barriers to rapid surveillance were identified. Investment in robust surveillance should be prioritized to prepare for future pandemics.", "doi": "10.1111/aogs.14643", "pmid": "37594175", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:01:41.758Z", "modified": "2023-10-05T08:31:24.775Z"}, {"entity": "publication", "iuid": "fd298155e85d4de1bf6e8e9532a22e63", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fd298155e85d4de1bf6e8e9532a22e63.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fd298155e85d4de1bf6e8e9532a22e63"}}, "title": "Hospital Admission Rates in Patients with COPD Throughout the COVID-19 Pandemic.", "authors": [{"family": "Andreen", "given": "Niklas", "initials": "N", "orcid": "0000-0002-7349-3120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/112f52ac7eb84986ba16b220903beb5f.json"}}, {"family": "Westin", "given": "Johan", "initials": "J"}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW", "orcid": "0000-0002-4387-4096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bb5d1f761ef48c4837ed4f984717f0e.json"}}], "type": "journal article", "published": "2023-08-17", "journal": {"title": "Int J Chron Obstruct Pulmon Dis", "issn": "1178-2005", "issn-l": null, "volume": "18", "issue": null, "pages": "1763-1772"}, "abstract": "Several studies report decreased hospital admissions for acute exacerbations of COPD (AECOPD) during the COVID-19 pandemic. However, there are no studies that compare AECOPD admissions with admissions for respiratory infections, including COVID-19. This study aimed to examine hospital admission rates for AECOPD, pneumonia, influenza, and COVID-19 among COPD patients, before and during the COVID-19 pandemic.\r\n\r\nWe obtained anonymized data on hospital admissions of patients with COPD and a primary diagnosis code for AECOPD, pneumonia, influenza, or COVID-19, from the hospital patient admission register at a large Swedish hospital. The study compared the pandemic period (February 2020-March 2022) to a period before the pandemic (June 2017-January 2020). Sequential phases of the pandemic were evaluated separately. Monthly admission rates were compared using Poisson regression, controlling for admission month.\r\n\r\nComparing monthly admission rates during the pandemic with the prepandemic period, incidence rate ratios were 0.72 for AECOPD (95% CI 0.67-0.77; p<0.001), 0.56 for pneumonia (95% CI 0.49-0.62; p<0.001), 0.18 for influenza during the winter period (95% CI 0.10-0.30; p<0.001) and 0.79 for total COPD admissions, including COVID-19 (95% CI 0.75-0.84; p<0.001). The study showed significantly lower rate ratios for AECOPD, pneumonia, and total COPD admissions during the first, second, third, and fifth (Omicron) waves. No significant effect on admissions was seen after the withdrawal of restriction measures.\r\n\r\nThere was a significant reduction in the overall rate of hospital admissions among COPD patients for AECOPD, pneumonia, and respiratory viral infections during the pandemic despite the rise in COVID-19 admissions. However, prepandemic admission levels returned in the post-restriction period.", "doi": "10.2147/COPD.S409452", "pmid": "37608833", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC10441640"}, {"db": "pii", "key": "409452"}], "notes": [], "created": "2023-10-05T08:02:43.676Z", "modified": "2023-10-05T08:51:00.004Z"}, {"entity": "publication", "iuid": "b8666e1363444f6787a65e606a5a9b78", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8666e1363444f6787a65e606a5a9b78.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8666e1363444f6787a65e606a5a9b78"}}, "title": "Pandemic stressors and mental health indicators in eight countries.", "authors": [{"family": "Abdalla", "given": "Salma M", "initials": "SM"}, {"family": "Koya", "given": "Shaffi Fazaludeen", "initials": "SF"}, {"family": "Rosenberg", "given": "Samuel B", "initials": "SB"}, {"family": "Stovall", "given": "Isaac B", "initials": "IB"}, {"family": "Biermann", "given": "Olivia", "initials": "O"}, {"family": "Zeinali", "given": "Zahra", "initials": "Z"}, {"family": "Cohen", "given": "Gregory H", "initials": "GH"}, {"family": "Ettman", "given": "Catherine K", "initials": "CK"}, {"family": "Galea", "given": "Sandro", "initials": "S"}], "type": "journal article", "published": "2023-08-16", "journal": {"title": "Soc Psychiatry Psychiatr Epidemiol", "issn": "1433-9285", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The Covid-19 pandemic has exacted a significant physical, financial, social, and emotional toll on populations throughout the world. This study aimed to document the association between pandemic stressors and mental health during the pandemic across countries that differ in cultural, geographic, economic, and demographic factors.\r\n\r\nWe administered an online survey randomly in Brazil, China, Germany, Egypt, India, Indonesia, Nigeria, and the United States from September 2020 to November 2020. This survey included questions on Covid-19-related stressors as well as the Patient Health Questionnaire-2 and the Primary Care PTSD Checklist to screen for depression and post-traumatic stress disorder (PTSD) symptoms, respectively. We performed bivariable and multivariable regression analyses to assess the prevalence and odds ratios of overall depression symptoms and probable PTSD and in relation to stressors across countries.\r\n\r\nAmong 8754 respondents, 28.9% (95% CI 27.5-30.0%) experienced depression symptoms, and 5.1% (95% CI 4.5-6.0%) experienced probable PTSD. The highest prevalence of depression symptoms was in Egypt (41.3%, 95% CI 37.6-45.0%) and lowest in the United States (24.9%, 95% CI 22.3-27.7%). The highest prevalence of probable PTSD was in Brazil (7.3%, 95% CI 5.6-9.4%) and the lowest in China (1.2%, 95% CI 0.7-2.0%). Overall, experiencing six or more Covid-19-related stressors was associated with both depression symptoms (OR 1.90, 95% CI 1.46-2.48) and probable PTSD (OR 13.8, 95% CI 9.66-19.6).\r\n\r\nThe association between pandemic related stressors and the burden of adverse mental health indicators early in the Covid-19 pandemic transcended geographic, economic, cultural, and demographic differences between countries. The short-term and long-term impacts of the pandemic on mental health should be incorporated in efforts to tackle the consequences of Covid-19.", "doi": "10.1007/s00127-023-02541-w", "pmid": "37587229", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00127-023-02541-w"}], "notes": [], "created": "2023-10-05T08:08:56.769Z", "modified": "2023-10-06T04:41:31.399Z"}, {"entity": "publication", "iuid": "3a7396ea5aa8414ab1dbf4c1cb3eb871", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a7396ea5aa8414ab1dbf4c1cb3eb871.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a7396ea5aa8414ab1dbf4c1cb3eb871"}}, "title": "COVID-19 Restrictions Resulted in Both Positive and Negative Effects on Digital Media Use, Mental Health, and Lifestyle Habits.", "authors": [{"family": "Nutley", "given": "Sissela B", "initials": "SB", "orcid": "0000-0002-0676-0380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76343d4da98a4fa0b45ae8cd79ceb6ae.json"}}, {"family": "Bur\u00e9n", "given": "Jonas", "initials": "J"}, {"family": "Thorell", "given": "Lisa B", "initials": "LB", "orcid": "0000-0002-7417-6637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c947bd794d04fd492bca68071260ed5.json"}}], "type": "journal article", "published": "2023-08-16", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "20", "issue": "16", "pages": null}, "abstract": "While studies have reported effects on digital media during the COVID-19 restrictions, few have included data prior to the pandemic, and most have only measured screen time. We therefore investigated changes in specific digital media activities, as well as mental health and lifestyle habits, in a longitudinal study of adolescents spanning from before the pandemic (T1) to one month into restrictions (T2) and one year later when schools had reopened (T3). Adolescents (16-19 years) rated smartphone use, problematic/addictive media use, negative experiences (e.g., victimization), mental health (i.e., irritability, stress, and closeness), and protective lifestyle habits (i.e., sleep and exercise). Results showed initial decreases in irritability and negative digital experiences, increases in sleep and exercise, as well as a decrease in closeness during remote learning (T2). However, these changes returned to, or superseded, their initial levels at follow-up (T3). There were also increases in digital media use and stress at T3. Conclusively, by investigating specific digital media activities and collecting data both prior to and during different phases of the pandemic, we were able to find both positive and negative effects.", "doi": "10.3390/ijerph20166583", "pmid": "37623169", "labels": {"Type: Journal article": null, "Funder: Forte": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10454500"}, {"db": "pii", "key": "ijerph20166583"}], "notes": [], "created": "2023-10-05T08:26:48.574Z", "modified": "2023-10-06T05:06:46.288Z"}, {"entity": "publication", "iuid": "47f7b9fd9c1f4e7a85351dc2de766f48", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47f7b9fd9c1f4e7a85351dc2de766f48.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47f7b9fd9c1f4e7a85351dc2de766f48"}}, "title": "Nursing Students' Computer Anxiety and Attitudes Before and During the COVID-19 Pandemic.", "authors": [{"family": "Papathanasiou", "given": "Ioanna V", "initials": "IV"}, {"family": "Mantzaris", "given": "Dimitrios", "initials": "D"}, {"family": "Fradelos", "given": "Evangelos C", "initials": "EC"}, {"family": "Christodoulou", "given": "Nikolaos G", "initials": "NG"}, {"family": "Lee", "given": "Ka Yiu", "initials": "KY"}, {"family": "Tsaloglidou", "given": "Areti", "initials": "A"}, {"family": "Albani", "given": "Eleni", "initials": "E"}, {"family": "Malli", "given": "Foteini", "initials": "F"}, {"family": "Gourgoulianis", "given": "Konstantinos I", "initials": "KI"}], "type": "journal article", "published": "2023-08-15", "journal": {"title": "Adv Exp Med Biol", "issn": "0065-2598", "issn-l": null, "volume": "1425", "issue": null, "pages": "377-391"}, "abstract": "Purpose of this research was to investigate how the COVID-19 pandemic affected the level of computer anxiety of nursing students and also their attitude related to computer use. A cross-sectional study was conducted in two periods, one before the COVID-19 pandemic (1st period) and the second during the COVID-19 pandemic (2nd period). The research instrument consisted of three parts, a questionnaire with questions about demographic and educational characteristics such as gender and semester of study, the Computer Anxiety Rating Scale (CARS), that used to assess the nursing students' levels of computer anxiety and the Computer Attitude Scale (CAS) that used to measure nursing students' positive and negative attitudes towards computers. Data from 957 undergraduate nursing students were obtained. Specifically, in the 1st period, 370 nursing students participated (38.66%), while in the 2nd period 587 (61.34%) undergraduates participated. The anxiety of participants during COVID-19 pandemic period was reduced compared to that of participants before the COVID-19 period. Respondents during the COVID-19 pandemic have fewer negative feelings towards computers, based on their answers in contrast to the participants in the study before the COVID-19 pandemic. Computer anxiety and attitudes have change among nursing students among COVID-19 pandemic. Nursing students after the implementation of online training are reporting positive feeling towards computer use and are more confident for their ICT skills.", "doi": "10.1007/978-3-031-31986-0_37", "pmid": "37581812", "labels": {"Type: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:26:12.089Z", "modified": "2023-10-06T04:49:37.366Z"}, {"entity": "publication", "iuid": "eb4c2d66486d424195bec82ba310b6ab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb4c2d66486d424195bec82ba310b6ab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb4c2d66486d424195bec82ba310b6ab"}}, "title": "Inequalities in COVID-19 severe morbidity and mortality by country of birth in Sweden.", "authors": [{"family": "Rostila", "given": "Mikael", "initials": "M", "orcid": "0000-0002-6973-0381", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42aa27e8e952465daa11c765ad564808.json"}}, {"family": "Cederstr\u00f6m", "given": "Agneta", "initials": "A"}, {"family": "Wallace", "given": "Matthew", "initials": "M", "orcid": "0000-0002-8318-7952", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e784144db22491f98c4a7ced1fdfab7.json"}}, {"family": "Aradhya", "given": "Siddartha", "initials": "S", "orcid": "0000-0003-3748-6270", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07f9e1a0528249a7ba6d39e2c0f3a7fe.json"}}, {"family": "Ahrne", "given": "Malin", "initials": "M"}, {"family": "Ju\u00e1rez", "given": "Sol P", "initials": "SP"}], "type": "journal article", "published": "2023-08-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "14", "issue": "1", "pages": "4919"}, "abstract": "Migrants have been more affected by the COVID-19 pandemic. Whether this has varied over the course of the pandemic remains unknown. We examined how inequalities in intensive care unit (ICU) admission and death related to COVID-19 by country of birth have evolved over the course of the pandemic, while considering the contribution of social conditions and vaccination uptake. A population-based cohort study was conducted including adults living in Sweden between March 1, 2020 and June 1, 2022 (n = 7,870,441). Poisson regressions found that migrants from Africa, Middle East, Asia and European countries without EU28/EEA, UK and Switzerland had higher risk of COVID-19 mortality and ICU admission than Swedish-born. High risks of COVID-19 ICU admission was also found in migrants from South America. Inequalities were generally reduced through subsequent waves of the pandemic. In many migrant groups socioeconomic status and living conditions contributed to the disparities while vaccination campaigns were decisive when such became available.", "doi": "10.1038/s41467-023-40568-4", "pmid": "37582909", "labels": {"Type: Journal article": null, "Funder: Forte": null, "Category: Public Health": null, "Category: Social Science & Humanities": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC10427621"}, {"db": "pii", "key": "10.1038/s41467-023-40568-4"}], "notes": [], "created": "2023-10-05T08:02:36.268Z", "modified": "2023-10-05T08:47:35.755Z"}, {"entity": "publication", "iuid": "380828967d5742d18e08ee66be00f624", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/380828967d5742d18e08ee66be00f624.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/380828967d5742d18e08ee66be00f624"}}, "title": "Influence of experience, tenure, and organisational preparedness on nurses' readiness in responding to disasters: An exploration during the COVID-19 pandemic.", "authors": [{"family": "Goniewicz", "given": "Mariusz", "initials": "M"}, {"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}, {"family": "W\u0142oszczak-Szubzda", "given": "Anna", "initials": "A"}, {"family": "Lasota", "given": "Dorota", "initials": "D"}, {"family": "Al-Wathinani", "given": "Ahmed M", "initials": "AM"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}], "type": "journal article", "published": "2023-08-14", "journal": {"title": "J Glob Health", "issn": "2047-2986", "issn-l": "2047-2978", "volume": "13", "issue": null, "pages": "06034"}, "abstract": "The coronavirus 2019 (COVID-19) pandemic has placed unprecedented challenges on the nursing practice, particularly in Poland. Nurses, as crucial healthcare service providers, have faced organisational disruptions, altered working conditions, and heightened professional anxieties.\r\n\r\nWe undertook a comprehensive survey across all medical centres in Lublin, Poland in 2020 to understand nurses' attitudes towards their roles and working conditions during the pandemic. This involved 470 nurses completing a questionnaire which focused on four pivotal areas: readiness to be on call in a disaster situation (even when not formally asked); willingness to work overtime in a disaster without additional compensation, preparedness to undertake health risks by caring for individuals with infectious diseases or exposure to hazardous substances, and willingness to be transferred to other departments during a disaster.\r\n\r\nWe found that excessive workload, fear of infection, and feelings of helplessness significantly influenced nurses' readiness to work overtime, particularly when unpaid. We also presented the ethical dilemmas that nurses encountered during the pandemic and how these dilemmas affected their decision-making processes. We further explored the impact of variables such as nurses' professional experience, tenure, and level of organisational preparedness on their readiness to respond to crisis situations.\r\n\r\nGaining an understanding of nurses' perspectives is key for formulating strategies to bolster their professional engagements and resilience during crises. Addressing these issues can help build a more robust and well-prepared healthcare system that can effectively navigate future crises.", "doi": "10.7189/jogh.13.06034", "pmid": "37572372", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10423066"}], "notes": [], "created": "2023-10-05T08:26:54.564Z", "modified": "2023-10-06T05:17:33.511Z"}, {"entity": "publication", "iuid": "5f742fa06f844a49b6242edfc3f1de15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f742fa06f844a49b6242edfc3f1de15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f742fa06f844a49b6242edfc3f1de15"}}, "title": "Waning protection after vaccination and prior infection against COVID-19-related mortality over 18 months.", "authors": [{"family": "Dietler", "given": "Dominik", "initials": "D"}, {"family": "Kahn", "given": "Fredrik", "initials": "F"}, {"family": "Inghammar", "given": "Malin", "initials": "M"}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2023-08-12", "journal": {"title": "Clin Microbiol Infect", "issn": "1469-0691", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Evidence on waning patterns in protection from vaccine-induced, infection-induced, and hybrid immunity against death is scarce. The aim of this study is to assess the temporal trends in protection against mortality.\r\n\r\nPopulation-based case-control study nested in the total population of Scania Region, Sweden using individual-level registry data of COVID-19-related deaths (<30 days after positive SARS-CoV-2 test) between 27 December 2020 and 3 June 2022. Controls were matched for age, sex, and index date. Conditional logistic regression was used to estimate the preventable fraction (PF) from vaccination (PFvac corresponding to vaccine effectiveness; \u22652 vaccine doses vs. 0 doses), prior infection (PFinf), and hybrid immunity (PFhybrid). PF was calculated as one minus odds ratio. Models were adjusted for comorbidities, long-term care facility residence, prior infection (for PFvac), country of birth, socio-economic conditions, and time since last vaccination (for PFinf).\r\n\r\nIn total, 14 936 individuals (1440 COVID-19-related deaths and 13 496 controls) were included in the case-control analyses (45% females, median age: 84 years). PFvac was above 90% during the first month after vaccination, regardless of the number of vaccine doses. After 6 months, PFvac of two doses waned to 34% (95% CI: -30% to 66%). PFinf for people surviving a SARS-CoV-2 infection waned from 88% (-16% to 99%) 3 months after infection to 62% (34-79%) after 9 months. No differences in waning patterns in PFvac were seen between virus variants, gender, and age.\r\n\r\nGiven the waning of protection against death, continuous surveillance of population immunity status, particularly among the most vulnerable population groups, could help to further fine-tune vaccination recommendations.", "doi": "10.1016/j.cmi.2023.08.007", "pmid": "37580016", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Public Health": null, "Funder: Vinnova": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(23)00388-9"}], "notes": [], "created": "2023-10-05T08:02:23.898Z", "modified": "2023-10-05T08:41:21.267Z"}, {"entity": "publication", "iuid": "8525adc10add43ec92a8865a509bd63b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8525adc10add43ec92a8865a509bd63b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8525adc10add43ec92a8865a509bd63b"}}, "title": "Central nervous system biomarkers GFAp and NfL associate with post-acute cognitive impairment and fatigue following critical COVID-19.", "authors": [{"family": "Bark", "given": "Lovisa", "initials": "L"}, {"family": "Larsson", "given": "Ing-Marie", "initials": "I"}, {"family": "Wallin", "given": "Ewa", "initials": "E"}, {"family": "Simr\u00e9n", "given": "Joel", "initials": "J"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2023-08-12", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "13144"}, "abstract": "A high proportion of patients with coronavirus disease 2019 (COVID-19) experience post-acute COVID-19, including neuropsychiatric symptoms. Objective signs of central nervous system (CNS) damage can be investigated using CNS biomarkers such as glial fibrillary acidic protein (GFAp), neurofilament light chain (NfL) and total tau (t-tau). We have examined whether CNS biomarkers can predict fatigue and cognitive impairment 3-6 months after discharge from the intensive care unit (ICU) in critically ill COVID-19 patients. Fifty-seven COVID-19 patients admitted to the ICU were included with analysis of CNS biomarkers in blood at the ICU and at follow up. Cognitive dysfunction and fatigue were assessed with the Montreal Cognitive Assessment (MoCA) and the Multidimensional Fatigue inventory (MFI-20). Elevated GFAp at follow-up 3-6 months after ICU discharge was associated to the development of mild cognitive dysfunction (p = 0.01), especially in women (p = 0.005). Patients who experienced different dimensions of fatigue at follow-up had significantly lower GFAp in both the ICU and at follow-up, specifically in general fatigue (p = 0.009), physical fatigue (p = 0.004), mental fatigue (p = 0.001), and reduced motivation (p = 0.001). Women showed a more pronounced decrease in GFAp compared to men, except for in mental fatigue where men showed a more pronounced GFAp decrease compared to women. NfL concentration at follow-up was lower in patients who experienced reduced motivation (p = 0.004). Our findings suggest that GFAp and NfL are associated with neuropsychiatric outcome after critical COVID-19.Trial registration The study was registered \u00e0 priori (clinicaltrials.gov: NCT04316884 registered on 2020-03-13 and NCT04474249 registered on 2020-06-29).", "doi": "10.1038/s41598-023-39698-y", "pmid": "37573366", "labels": {"Funder: VR": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: KAW/SciLifeLab": null, "Category: Post-COVID": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10423244"}, {"db": "pii", "key": "10.1038/s41598-023-39698-y"}, {"db": "ClinicalTrials.gov", "key": "NCT04316884"}, {"db": "ClinicalTrials.gov", "key": "NCT04474249"}], "notes": [], "created": "2023-10-05T08:02:46.150Z", "modified": "2023-10-05T08:52:57.648Z"}, {"entity": "publication", "iuid": "19645b528efb4222a1fa99f67fcfa83f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19645b528efb4222a1fa99f67fcfa83f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19645b528efb4222a1fa99f67fcfa83f"}}, "title": "Transparency in Infectious Disease Research: Meta-research Survey of Specialty Journals.", "authors": [{"family": "Zavalis", "given": "Emmanuel A", "initials": "EA"}, {"family": "Contopoulos-Ioannidis", "given": "Despina G", "initials": "DG"}, {"family": "Ioannidis", "given": "John P A", "initials": "JPA"}], "type": "journal article", "published": "2023-08-11", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899", "volume": "228", "issue": "3", "pages": "227-234"}, "abstract": "Infectious diseases carry large global burdens and have implications for society at large. Therefore, reproducible, transparent research is extremely important.\r\n\r\nWe evaluated transparency indicators (code and data sharing, registration, and conflict and funding disclosures) in the 5340 PubMed Central Open Access articles published in 2019 or 2021 in the 9 most cited specialty journals in infectious diseases using the text-mining R package, rtransparent.\r\n\r\nA total of 5340 articles were evaluated (1860 published in 2019 and 3480 in 2021 [of which 1828 were on coronavirus disease 2019, or COVID-19]). Text mining identified code sharing in 98 (2%) articles, data sharing in 498 (9%), registration in 446 (8%), conflict of interest disclosures in 4209 (79%), and funding disclosures in 4866 (91%). There were substantial differences across the 9 journals: 1%-9% for code sharing, 5%-25% for data sharing, 1%-31% for registration, 7%-100% for conflicts of interest, and 65%-100% for funding disclosures. Validation-corrected imputed estimates were 3%, 11%, 8%, 79%, and 92%, respectively. There were no major differences between articles published in 2019 and non-COVID-19 articles in 2021. In 2021, non-COVID-19 articles had more data sharing (12%) than COVID-19 articles (4%).\r\n\r\nData sharing, code sharing, and registration are very uncommon in infectious disease specialty journals. Increased transparency is required.", "doi": "10.1093/infdis/jiad130", "pmid": "37132475", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7150367"}], "notes": [], "created": "2023-10-04T05:09:56.676Z", "modified": "2023-10-04T06:24:40.130Z"}, {"entity": "publication", "iuid": "7a9030d1303f42c58b565c64d9aa8399", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a9030d1303f42c58b565c64d9aa8399.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a9030d1303f42c58b565c64d9aa8399"}}, "title": "Real-World Utilization of Molnupiravir during the COVID-19 Omicron Surge in Israel.", "authors": [{"family": "Weil", "given": "Clara", "initials": "C", "orcid": "0000-0002-0174-7208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7720ae3cd164504b6b6cb631a334704.json"}}, {"family": "Bergroth", "given": "Tobias", "initials": "T"}, {"family": "Eisenberg", "given": "Anna", "initials": "A", "orcid": "0000-0003-4292-0967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/983fc62ecb3544619b5430598e7a50c9.json"}}, {"family": "Whiteside", "given": "Yohance Omar", "initials": "YO", "orcid": "0000-0002-7828-3018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce7b53acac3441df9dc098073b66b995.json"}}, {"family": "Caraco", "given": "Yoseph", "initials": "Y"}, {"family": "Tene", "given": "Lilac", "initials": "L"}, {"family": "Chodick", "given": "Gabriel", "initials": "G", "orcid": "0000-0002-5189-8995", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed9fe6a3219549849c751198e9c47e1c.json"}}], "type": "journal article", "published": "2023-08-10", "journal": {"title": "Epidemiologia (Basel)", "issn": "2673-3986", "issn-l": null, "volume": "4", "issue": "3", "pages": "309-321"}, "abstract": "Molnupiravir (MOV) was introduced in Israel in January 2022 during the SARS-CoV-2 Omicron surge for high-risk patients contraindicated for nirmatrelvir/ritonavir. This retrospective cohort study aimed to describe characteristics of patients offered COVID-19 antiviral treatment in Maccabi Healthcare Services (antiviral treatment-eligible cohort; n = 5596) between 12 January and 28 February 2022, and the subset of these who were dispensed MOV (MOV-treated cohort; n = 1147), as well as outcomes following MOV dispensation. Median (interquartile range) age in the antiviral treatment-eligible and MOV-treated cohorts were 70.5 (61.1, 77.3) and 74.1 (64.3, 81.7) years, respectively. The MOV-treated cohort (male: 53.2%) had high rates of COVID-19 vaccination (91.4%) and comorbidities, including immunosuppression (40.0%) and chronic kidney disease (67.0%; eGFR < 30 mL/min/1.73 m2: 28.8%), and most used comedications either contraindicated or with major potential for drug-drug interactions with nirmatrelvir/ritonavir (87.3%). At 28 days post-MOV dispensation, the cumulative incidence (95% CI) of COVID-19-related hospitalization and/or all-cause mortality was 3.6% (2.5%, 4.6%), with similar rates across sexes and age groups (18-64 vs. \u226565 years), and lower rates among recently vaccinated and/or recently SARS-CoV-2-infected patients. These data describe the characteristics and outcomes for MOV-treated patients in Israel, whose clinical characteristics may preclude the use of nirmatrelvir/ritonavir to treat their COVID-19 infection.", "doi": "10.3390/epidemiologia4030031", "pmid": "37606468", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10443270"}, {"db": "pii", "key": "epidemiologia4030031"}], "notes": [], "created": "2023-10-05T08:01:45.632Z", "modified": "2023-10-05T08:34:09.246Z"}, {"entity": "publication", "iuid": "170e5853d8cc408d975bf1beb2797485", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/170e5853d8cc408d975bf1beb2797485.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/170e5853d8cc408d975bf1beb2797485"}}, "title": "Asthma in the era of COVID-19.", "authors": [{"family": "Assaf", "given": "Sara", "initials": "S"}, {"family": "Stenberg", "given": "Henning", "initials": "H"}, {"family": "Jesenak", "given": "Milos", "initials": "M"}, {"family": "Tarasevych", "given": "Svitlana P", "initials": "SP"}, {"family": "Hanania", "given": "Nicola A", "initials": "NA"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}], "type": "journal article", "published": "2023-08-10", "journal": {"title": "Respir Med", "issn": "1532-3064", "issn-l": "0954-6111", "volume": "218", "issue": null, "pages": "107373"}, "abstract": "Since its global invasion in 2019, COVID-19 has affected several aspects of patients' lives and posed a significant impact on the health care system. Several patient populations were identified to be at high risk of contracting SARS-CoV-2 infection and/or developing severe COVID-19-related sequelae. Conversely, anyone who has contracted SARS-CoV-2 is at risk to experience symptoms and signs consistent with post-COVID manifestations. Patients with asthma were initially thought to be at increased risk and severity for SARS-CoV-2 infection. However, accumulating evidence demonstrates that asthma endotypes/phenotypes and comorbidities influence the risk stratification in this population. Furthermore, initial concerns about the potentially increased risk of poor outcomes with asthma treatments such as inhaled corticosteroids and biologics have not been substantiated. In this review, we provide an update on COVID-19 and asthma, including risk of susceptibility, clinical manifestations and course in this population as well as discuss recommendations for management.", "doi": "10.1016/j.rmed.2023.107373", "pmid": "37567514", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0954-6111(23)00261-5"}], "notes": [], "created": "2023-10-05T08:01:36.893Z", "modified": "2023-10-05T08:29:04.018Z"}, {"entity": "publication", "iuid": "a387f635b5584204bd765f1418785203", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a387f635b5584204bd765f1418785203.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a387f635b5584204bd765f1418785203"}}, "title": "Effects of the COVID-19 pandemic on the physical activity and screen time habits of children aged 11-13 years in Sweden.", "authors": [{"family": "Berggren", "given": "Sara", "initials": "S"}, {"family": "Almquist-Tangen", "given": "Gerd", "initials": "G"}, {"family": "Wolfbrandt", "given": "Olivia", "initials": "O"}, {"family": "Roswall", "given": "Josefine", "initials": "J"}], "type": "journal article", "published": "2023-08-09", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "1241938"}, "abstract": "Physical activity (PA), exercise, sedentary behavior and screen time are lifestyle factors that have been shown to significantly impact child health in different ways. These lifestyle factors were affected to different degrees by global restrictions during the COVID-19 pandemic. We investigated PA and screen time in a cohort of Swedish children in both 2019 and 2021, before and during the pandemic.\r\n\r\nAdolescents born in 2008 in Halland, Sweden, and included in a previous longitudinal birth cohort study were invited to take part in follow-up questionnaires about PA, screen time and COVID-19. A total of 1041 children aged 11 (in 2019) and 13 years (in 2021) replied and 777 of them answered on both occasions.\r\n\r\nMost children (42.1%) reported that their leisure time PA was unchanged from 2019 to 2021. Compared to unchanged PA 33.9% exercised more often (p = 0.011) and 23.9% exercised less (p < 0.001), both differences statistically significant. Roughly, 43.2% of boys and 34.9% of girls in 2021 exercised so that they became breathless or broke a sweat at least 4 times a week not counting physical education in school, corresponding figures for 2019 were 38.2% for boys and 35.2% for girls. The majority of children were able to continue attending leisure time sports clubs during the pandemic, but participation decreased from 88.3% to 76.3% from 11 to 13 years of age. Most reported that sports club routines changed during the pandemic, but only 40.9% reported fewer practice opportunities. Attending a sports club gave greater protection against loss of PA during the pandemic than not belonging to one (41.0% vs. 23.2%, p < 0.001). The majority (71.1%) of children spent more time on screens in 2021 than 2019, with a mean increase of 9.4 h (95% CI 8.6 to 10.2 h) from 20.7 to 30.1 hours per week (p < 0.001) during the study.\r\n\r\nSwedish children largely maintained their levels of PA during the pandemic at 13 years of age and these were possibly safeguarded by the comparably mild pandemic restrictions in Sweden in 2021. However, they did increase their screen time between 11 and 13 years of age.", "doi": "10.3389/fpubh.2023.1241938", "pmid": "37637825", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10447604"}], "notes": [], "created": "2023-10-05T08:26:38.406Z", "modified": "2023-10-06T05:01:54.058Z"}, {"entity": "publication", "iuid": "170bf933f9e242adac8adf3c85197e5f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/170bf933f9e242adac8adf3c85197e5f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/170bf933f9e242adac8adf3c85197e5f"}}, "title": "Regular Inhaled Corticosteroids Use May Protect Against Severe COVID-19 Outcome in COPD.", "authors": [{"family": "Labor", "given": "Marina", "initials": "M", "orcid": "0000-0001-5216-8129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9a750b29a224b7bb07d535004dfdf15.json"}}, {"family": "Kirui", "given": "Brian K", "initials": "BK", "orcid": "0000-0002-6656-6029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b22b96547b344c79b3780723af1f30e0.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW", "orcid": "0000-0002-4387-4096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bb5d1f761ef48c4837ed4f984717f0e.json"}}], "type": "journal article", "published": "2023-08-07", "journal": {"title": "Int J Chron Obstruct Pulmon Dis", "issn": "1178-2005", "issn-l": null, "volume": "18", "issue": null, "pages": "1701-1712"}, "abstract": "Population-based studies provide conflicting evidence about how inhaled corticosteroids (ICS) impact COVID-19 outcomes among COPD patients. We investigated whether regular ICS exposure affects risk, severity, or survival in SARS-CoV-2 infection, using a nationwide linked Swedish population register database.\r\n\r\nDuring January-December 2020, we studied two defined Swedish adult populations - Whole population [\u226540 years] (N = 5243479), and COPD subpopulation [\u226540 years] (N = 133372), in three study cohorts, respectively: 1. Overall cohort (index date 1 Jan 2020), 2. COVID-19 diagnosed sub-cohort (index date = diagnosis date), and 3. COVID-19 hospitalized sub-cohort (index date = admission date). Regular exposure was defined as \u22653 ICS prescriptions in the year before index. Hazard ratios (HRs) for outcomes (COVID-19 onset, hospitalization, ICU admission, or death) related to ICS exposure were estimated using Cox regression. Confounding was controlled by propensity score methods applying Average Treatment effect in the Treated (ATT) weighting.\r\n\r\nRegular ICS use was associated with only very slightly increased onset of COVID-19, hospitalization, ICU admission, and death in the overall whole population cohort and in the overall COPD subpopulation cohort, except for ICU admission (marginally non-significant HRs, up to 1.13); and no clear increase in the diagnosed sub-cohorts. However, in the COVID-19 hospitalized COPD sub-cohort, ICS therapy showed reduced risks against progression to ICU admission and death, significant for death (HR 0.82 95% CI [0.67-0.99]).\r\n\r\nFor COPD patients, ICS therapy offers some protection against progression to ICU admission and death among COVID-19 hospitalized patients. Our findings alleviate concerns about increased risks of COVID-19 by ICS treatment and provide evidence supporting the continuation of ICS therapy for COPD patients.", "doi": "10.2147/COPD.S404913", "pmid": "37576828", "labels": {"Funder: VR": null, "Category: Public Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC10421743"}, {"db": "pii", "key": "404913"}], "notes": [], "created": "2023-10-05T08:01:51.832Z", "modified": "2023-10-05T08:36:13.679Z"}, {"entity": "publication", "iuid": "90cc886cb05544c79682111b99061687", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90cc886cb05544c79682111b99061687.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90cc886cb05544c79682111b99061687"}}, "title": "Attachment and trauma-informed programme to support forcibly displaced parents of youth in Sweden: feasibility and preliminary outcomes of the eConnect Online programme.", "authors": [{"family": "Kristen", "given": "Anna", "initials": "A", "orcid": "0000-0002-6020-7711", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5c8e51cf2423417a8e0a2c7dc91b423f.json"}}, {"family": "Salari", "given": "Raziye", "initials": "R", "orcid": "0000-0002-6363-4030", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e135f6c46ce47af8be2b490675d4f3f.json"}}, {"family": "Moretti", "given": "Marlene", "initials": "M"}, {"family": "Osman", "given": "Fatumo", "initials": "F", "orcid": "0000-0002-0038-9402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4384d1f8230f4c939d1e5e0025e53013.json"}}], "type": "journal article", "published": "2023-08-07", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "8", "pages": "e072368"}, "abstract": "To assess the feasibility, acceptability and the impact of an online parenting programme for forcibly displaced parents of adolescents.\r\n\r\nThe study was a single-arm feasibility study using pre-intervention post-intervention and follow-up assessments.\r\n\r\nParticipants were recruited from municipality-based activities for refugee parents in a small city in the south of Sweden.\r\n\r\nParticipants were forcibly displaced parents (n=23; 47.8% maternal figures) of youth (n=23; 8-17 years old; 26.1% female) from Syria, Afghanistan and Somalia participating in an online parenting programme (eConnect).\r\n\r\neConnect is an attachment-based and trauma-informed parenting intervention and was delivered over the course of 10 weekly sessions.\r\n\r\nFeasibility was assessed by programme enrolment, attendance, completion and acceptability of the online platform and cultural fit of the programme. Primary outcome measures were programme impact on youth mental health problems. Secondary outcome measures were programme impact on family functioning and parent-child attachment insecurity.\r\n\r\nThe eConnect programme was highly feasible in terms of overall enrolment (100%), attendance (89.6%) and retention rates (100%). The online platform was acceptable, with mixed feedback primarily related to the access and usage of technology. Cultural fit of the programme was acceptable. Youth mental health problems (\u03b7 2=0.29) and family functioning significantly improved (\u03b7 2=0.18) over the course of the programme. Unexpectedly, parent reports of youth attachment insecurity significantly worsened (\u03b7 2=0.16).\r\n\r\nThe findings suggest that the online delivery of Connect was a promising way to reduce barriers to service access and improve mental health problems and family functioning among forcibly displaced parents and their children during COVID-19. Future research is needed to explore the acceptability and impact of this programme post-COVID-19, and to develop culturally tailored and psychometrically sound measures for parent and youth reports of attachment.", "doi": "10.1136/bmjopen-2023-072368", "pmid": "37550024", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10407377"}, {"db": "pii", "key": "bmjopen-2023-072368"}], "notes": [], "created": "2023-10-05T08:26:46.032Z", "modified": "2023-10-06T05:05:48.123Z"}, {"entity": "publication", "iuid": "654c48374d554572b94bcccd5d03900e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/654c48374d554572b94bcccd5d03900e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/654c48374d554572b94bcccd5d03900e"}}, "title": "National trends in depression and suicide attempts and COVID-19 pandemic-related factors, 1998-2021: A nationwide study in South Korea.", "authors": [{"family": "Kang", "given": "Jiseung", "initials": "J"}, {"family": "Park", "given": "Jaeyu", "initials": "J"}, {"family": "Lee", "given": "Hojae", "initials": "H"}, {"family": "Lee", "given": "Myeongcheol", "initials": "M"}, {"family": "Kim", "given": "Sunyoung", "initials": "S"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Smith", "given": "Lee", "initials": "L"}, {"family": "Kim", "given": "Min Seo", "initials": "MS"}, {"family": "Rahmati", "given": "Masoud", "initials": "M"}, {"family": "Fond", "given": "Guillaume", "initials": "G"}, {"family": "Boyer", "given": "Laurent", "initials": "L"}, {"family": "L\u00f3pez S\u00e1nchez", "given": "Guillermo F", "initials": "GF"}, {"family": "Elena", "given": "Dragioti", "initials": "D"}, {"family": "Cortese", "given": "Samuele", "initials": "S"}, {"family": "Kim", "given": "Tae", "initials": "T"}, {"family": "Yon", "given": "Dong Keon", "initials": "DK"}], "type": "journal article", "published": "2023-08-06", "journal": {"title": "Asian J Psychiatr", "issn": "1876-2026", "issn-l": null, "volume": "88", "issue": null, "pages": "103727"}, "abstract": "Despite the significant psychiatric effects of the COVID-19 pandemic, there's limited data on the prevalence and risk factors of depression and suicide attempts among South Korean adults.\r\n\r\nA nationwide cross-sectional study using the Korea National Health and Nutrition Examination Survey (KNHANES) data from 1998 to 2021 was conducted. Changes in prevalence and risk factors for depression and suicide attempts were assessed using weighted odds ratios or weighted beta coefficients.\r\n\r\nDuring the observation period (1998-2021), the prevalence of depression increased in the overall population; however, no significant surge was found regarding the COVID-19 pandemic, from 2.78% (95% CI, 2.41-3.15) in 1998-2005-4.96% (4.32-5.61) in 2020 and 5.06% (4.43-5.69) in 2021. However, immediately after the onset of the pandemic, younger ages, male sex, urban residence, higher education, and high economic status became significant vulnerable factors compared to pre-pandemic periods. The prevalence of suicide attempts remained stable, and there was no notable surge specifically related to the COVID-19 pandemic, from 0.23% (95% CI, 0.18-0.28) in 1998-2005-0.45% (0.25-0.66) in 2020 and 0.42% (0.24-0.60) in 2021. Furthermore, no distinct vulnerable factors associated with suicide attempts have been identified.\r\n\r\nThrough this nationwide serial cross-sectional survey study, we emphasized the need for understanding the differential impacts of global crises, such as COVID-19, across varied population subgroups, thereby highlighting the importance of specific and targeted mental health support strategies.", "doi": "10.1016/j.ajp.2023.103727", "pmid": "37633158", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S1876-2018(23)00283-6"}], "notes": [], "created": "2023-10-05T08:26:14.345Z", "modified": "2023-10-06T04:52:01.848Z"}, {"entity": "publication", "iuid": "f910f94cd1d24cac87d244b467352d0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f910f94cd1d24cac87d244b467352d0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f910f94cd1d24cac87d244b467352d0e"}}, "title": "COVID-19 among migrants, refugees, and internally displaced persons: systematic review, meta-analysis and qualitative synthesis of the global empirical literature", "authors": [{"family": "Hintermeier", "given": "Maren", "initials": "M"}, {"family": "Gottlieb", "given": "Nora", "initials": "N"}, {"family": "Rohleder", "given": "Sven", "initials": "S"}, {"family": "Oppenberg", "given": "Jan", "initials": "J"}, {"family": "Baroudi", "given": "Mazen", "initials": "M"}, {"family": "Pernitez-Agan", "given": "Sweetmavourneen", "initials": "S"}, {"family": "Lopez", "given": "Janice", "initials": "J"}, {"family": "Flores", "given": "Sergio", "initials": "S"}, {"family": "Mohsenpour", "given": "Amir", "initials": "A", "orcid": "0000-0001-8419-2430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45c5089d3d844b86b2556c2405d3bdba.json"}}, {"family": "Wickramage", "given": "Kolitha", "initials": "K"}, {"family": "Bozorgmehr", "given": "Kayvan", "initials": "K", "orcid": "0000-0002-1411-1209", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d618d677fbb34dccb3439d863b131350.json"}}], "type": "posted-content", "published": "2023-08-06", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.08.03.23293586", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:02:28.486Z", "modified": "2023-10-05T08:44:03.578Z"}, {"entity": "publication", "iuid": "3097f975fd2649e4b28e4007f8b731b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3097f975fd2649e4b28e4007f8b731b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3097f975fd2649e4b28e4007f8b731b1"}}, "title": "Alcohol, drug and tobacco prevention in Swedish municipalities - impact from the COVID-19 pandemic considering socio-demographic context.", "authors": [{"family": "Owen", "given": "Ulrika", "initials": "U"}, {"family": "M\u00e5nsdotter", "given": "Anna", "initials": "A"}, {"family": "Guldbrandsson", "given": "Karin", "initials": "K"}, {"family": "Lindstr\u00f6m", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2023-08-04", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": null, "issue": null, "pages": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic and measures to prevent the spread of the virus challenged public health practice at the local level in Sweden. The objective of this study was to explore the impact of the pandemic on the prevention of alcohol, drugs and tobacco (ADT) in Sweden during 2020-21 considering socio-demographic context.\r\n\r\nData were collected through the Public Health Agency's survey on ADT prevention in Swedish municipalities (N = 290). This study used data from 2020 and 2021, with a response rate of 90% and 88%, respectively. Survey data were analyzed in logistic regression models (odds ratios, P < 0.05, 95% confidence intervals) against variables of education level, income level and population size from national registers.\r\n\r\nA majority (n = 198, 76%) of the municipalities reported a decrease in ADT prevention during the pandemic. No correlation between the decrease in ADT prevention and socio-demographic conditions was detected. A majority (2020: n = 165, 63%; 2021: n = 174, 68%) of the municipalities also reported that ADT prevention was adapted, however less common in smaller municipalities and municipalities where residents had lower levels of education and lower incomes.\r\n\r\nADT prevention carried out by municipalities in Sweden was initially (2020) deeply affected by the preventive strategies against COVID-19. Adaptation of activities was less common in municipalities with more vulnerable socio-demographic situation. In policy, practice and research, the findings are important not only for continued progress on the national goal of equity in health but also for preparedness for future crises.", "doi": "10.1093/eurpub/ckad127", "pmid": "37541832", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "7237445"}], "notes": [], "created": "2023-10-05T08:26:09.552Z", "modified": "2023-10-06T04:48:21.765Z"}, {"entity": "publication", "iuid": "b025ee64be20412b8be8a8a218882fa0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b025ee64be20412b8be8a8a218882fa0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b025ee64be20412b8be8a8a218882fa0"}}, "title": "Acceptability of restrictions in the COVID-19 pandemic: a population-based survey in Denmark and Sweden.", "authors": [{"family": "Nilsen", "given": "Per", "initials": "P"}, {"family": "Seing", "given": "Ida", "initials": "I"}, {"family": "Sekhon", "given": "Mandeep", "initials": "M"}, {"family": "Kallemose", "given": "Thomas", "initials": "T"}, {"family": "Tj\u00f8rnh\u00f8j-Thomsen", "given": "Tine", "initials": "T"}, {"family": "Stef\u00e1nsd\u00f3ttir", "given": "Nina Th\u00f3rn\u00fd", "initials": "NT"}, {"family": "Vrangb\u00e6k", "given": "Karsten", "initials": "K"}, {"family": "Andersen", "given": "Ove", "initials": "O"}, {"family": "Kirk", "given": "Jeanette Wassar", "initials": "JW"}], "type": "journal article", "published": "2023-08-03", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "988882"}, "abstract": "Denmark and Sweden initially adopted different responses to the COVID-19 pandemic although the two countries share many characteristics. Denmark responded swiftly with many mandatory restrictions. In contrast, Sweden relied on voluntary restrictions and a more \"relaxed\" response during the first wave of the pandemic. However, increased rates of COVID-19 cases led to a new approach that involved many more mandatory restrictions, thus making Sweden's response similar to Denmark's in the second wave of the pandemic.\r\n\r\nThe aim was to investigate and compare the extent to which the populations in Denmark and Sweden considered the COVID-19 restrictions to be acceptable during the first two waves of the pandemic. The study also aimed to identify the characteristics of those who were least accepting of the restrictions in the two countries.\r\n\r\nCross-sectional surveys were conducted in Denmark and Sweden in 2021. The study population was sampled from nationally representative web panels in the two countries, consisting of 2,619 individuals from Denmark and 2,633 from Sweden. The questionnaire captured key socio-demographic characteristics. Acceptability was operationalized based on a theoretical framework consisting of seven constructs and one overarching construct.\r\n\r\nThe respondents' age and gender patterns were similar in the two countries. The proportion of respondents in Denmark who agreed with the statements (\"agree\" alternative) that captured various acceptability constructs was generally higher for the first wave than the second wave of the pandemic. The opposite pattern was seen for Sweden. In Denmark, 66% in the first wave and 50% in the second wave were accepting of the restrictions. The corresponding figures for Sweden was 42% (first wave) and 47% (second wave). Low acceptance of the restrictions, defined as the 25% with the lowest total score on the seven acceptability statements, was associated with younger age, male gender and lower education levels.\r\n\r\nRespondents in Sweden were more accepting of the restrictions in the second wave, when the country used many mandatory restrictions. In contrast, respondents in Denmark were more accepting of the restrictions in the first wave than in the second wave, implying an increased weariness to comply with the restrictions over time. There were considerable socio-demographic differences between those who expressed low acceptance of the restrictions and the others in both countries, suggesting the importance of tailoring communication about the pandemic to different segments of the population.", "doi": "10.3389/fpubh.2023.988882", "pmid": "37601192", "labels": {"Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10434523"}], "notes": [], "created": "2023-10-05T08:26:33.525Z", "modified": "2023-10-06T04:59:24.120Z"}, {"entity": "publication", "iuid": "d50f06e75b39478fa4be8f1aef867936", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d50f06e75b39478fa4be8f1aef867936.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d50f06e75b39478fa4be8f1aef867936"}}, "title": "Waves of inequality: income differences in intensive care due to Covid-19 in Sweden.", "authors": [{"family": "Gauffin", "given": "Karl", "initials": "K", "orcid": "0000-0001-9349-9936", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40b610dc330245929d1c3ea558ef9af4.json"}}, {"family": "\u00d6stergren", "given": "Olof", "initials": "O", "orcid": "0000-0002-7156-3260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d22b6331dfb4bd88e2935d0ddec1dd3.json"}}, {"family": "Cederstr\u00f6m", "given": "Agneta", "initials": "A"}], "type": "journal article", "published": "2023-08-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": "33", "issue": "4", "pages": "574-579"}, "abstract": "Socioeconomically vulnerable groups were overall more likely to develop severe Covid-19, but specific conditions in terms of preparedness, knowledge and the properties of the virus itself changed during the course of the pandemic. Inequalities in Covid-19 may therefore shift over time. This study examines the relationship between income and intensive care (ICU) episodes due to Covid-19 in Sweden during three distinct waves.\r\n\r\nThis study uses Swedish register data on the total adult population and estimates the relative risk (RR) of ICU episodes due to Covid-19 by income quartile for each month between March 2020 and May 2022, and for each wave, using Poisson regression analyses.\r\n\r\nThe first wave had modest income-related inequalities, while the second wave had a clear income gradient, with the lowest income quartile having an increased risk compared to the high-income group [RR: 1.55 (1.36-1.77)]. In the third wave, the overall need for ICU decreased, but RRs increased, particularly in the lowest income quartile [RR: 3.72 (3.50-3.96)]. Inequalities in the third wave were partly explained by differential vaccination coverage by income quartile, although substantial inequalities remained after adjustment for vaccination status [RR: 2.39 (2.20-2.59)].\r\n\r\nThe study highlights the importance of considering the changing mechanisms that connect income and health during a novel pandemic. The finding that health inequalities increased as the aetiology of Covid-19 became better understood could be interpreted through the lens of adapted fundamental cause theory.", "doi": "10.1093/eurpub/ckad094", "pmid": "37322545", "labels": {"Category: Social Science & Humanities": null, "Funder: Forte": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10393505"}, {"db": "pii", "key": "7199199"}], "notes": [], "created": "2023-10-04T09:30:28.649Z", "modified": "2023-10-04T09:56:34.789Z"}, {"entity": "publication", "iuid": "4844edf1bca7409c8a29d94b9035ba7c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4844edf1bca7409c8a29d94b9035ba7c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4844edf1bca7409c8a29d94b9035ba7c"}}, "title": "Trajectory of COVID-19 vaccine hesitancy post-vaccination and public's intention to take booster vaccines: A cross-sectional analysis.", "authors": [{"family": "Salman", "given": "Muhammad", "initials": "M"}, {"family": "Mallhi", "given": "Tauqeer Hussain", "initials": "TH"}, {"family": "Khan", "given": "Yusra Habib", "initials": "YH"}, {"family": "Mustafa", "given": "Zia Ul", "initials": "ZU"}, {"family": "Khan", "given": "Muhammad Tanveer", "initials": "MT"}, {"family": "Khan", "given": "Faiz Ullah", "initials": "FU"}, {"family": "Butt", "given": "Muhammad Hammad", "initials": "MH", "orcid": "0000-0003-4387-1351", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6671444d83444ea2a1c68fcb309b6338.json"}}, {"family": "Shehzadi", "given": "Naureen", "initials": "N"}, {"family": "Farrukh", "given": "Muhammad Junaid", "initials": "MJ"}, {"family": "Waheed", "given": "Maria", "initials": "M"}, {"family": "Azmat", "given": "Fatima", "initials": "F"}, {"family": "Saeed", "given": "Areej", "initials": "A"}, {"family": "Mazhar", "given": "Syeda Ayesha", "initials": "SA"}, {"family": "Ali", "given": "Asim", "initials": "A"}, {"family": "Ashfaq", "given": "Aisha", "initials": "A"}, {"family": "Hussain", "given": "Khalid", "initials": "K"}], "type": "journal article", "published": "2023-08-01", "journal": {"title": "Hum Vaccin Immunother", "issn": "2164-554X", "issn-l": null, "volume": "19", "issue": "2", "pages": "2225990"}, "abstract": "Vaccine hesitancy (VH) is not a new phenomenon in Pakistan and is regarded as one of the primary causes of unsatisfactory vaccination campaigns. This study determined post-vaccination COVID-19 VH, factors influencing COVID-19 vaccine uptake, and public's intent to receive booster vaccinations. A cross-sectional study was conducted among adult population of Lahore, Pakistan. Participants were recruited via convenience sampling between March and May 2022. SPSS version 22 was used for the data analysis. A total of 650 participants were included in the study (age = 28.1 \u00b1 9.7 years; male-to-female ratio nearly 1: 1). The majority of participants received Sinopharm followed by Sinovac vaccine. The top three reasons of vaccine uptake were \"only vaccinated individuals are allowed at the workplace, and educational institutes\" (Relative importance index (RII) = 0.749), \"only vaccinated people are allowed to go to markets, malls and other public places\" (RII = 0.746), and \"protect myself from the infection\" (RII = 0.742). The mean COVID-19 VH score was 24.5 \u00b1 6.2 (95% CI 23.9-24.9), with not being pro-vaccines and poor economic status were the significant predictors of COVID-19 vaccine hesitancy among immunized individuals (p < .05). Acceptance of booster vaccines was negatively associated with younger age and a lower level of education. Furthermore, being pro-vaccine was associated with a greater likelihood of accepting booster vaccines (p = .001). The Pakistani public continues to express VH toward COVID-19 vaccines. Therefore, aggressive measures must be taken to combat the community factors that contribute to it.", "doi": "10.1080/21645515.2023.2225990", "pmid": "37350298", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10332231"}], "notes": [], "created": "2023-10-04T09:31:38.960Z", "modified": "2023-10-04T10:51:23.112Z"}, {"entity": "publication", "iuid": "c58419bfaf374d5ea21b7e947d6e9f8c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c58419bfaf374d5ea21b7e947d6e9f8c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c58419bfaf374d5ea21b7e947d6e9f8c"}}, "title": "Symptoms of depression and anxiety among elite high school student-athletes in Sweden during the COVID-19 pandemic: A repeated cross-sectional study.", "authors": [{"family": "Andersson", "given": "Mitchell J", "initials": "MJ", "orcid": "0000-0002-4753-016X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/574c35f21dad4cdea3510e7fd446cd94.json"}}, {"family": "Kentt\u00e4", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0002-9921-6586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bd3e6dbe34a41eaad16944e0de23c70.json"}}, {"family": "Moesch", "given": "Karin", "initials": "K", "orcid": "0000-0001-6500-182X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/339f5d2f86d94553b0c95483ab7f832c.json"}}, {"family": "Borg", "given": "Elisabet", "initials": "E", "orcid": "0000-0002-7638-347X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/222e6cd7574241d6b963df4c8e4082d1.json"}}, {"family": "Claesdotter-Knutsson", "given": "Emma", "initials": "E", "orcid": "0000-0002-6832-2482", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8738736985b40b3bdf49061f734f62f.json"}}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A", "orcid": "0000-0002-5800-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec14ecdcc0654d8ea864f64ce195752b.json"}}], "type": "journal article", "published": "2023-08-01", "journal": {"title": "J Sports Sci", "issn": "1466-447X", "issn-l": null, "volume": null, "issue": null, "pages": "1-10"}, "abstract": "The COVID-19 pandemic precipitated numerous changes in daily life, including the cancellation and restriction of sports globally. Because sports participation contributes positively to the development of student-athletes, restricting these activities may have led to long-term mental health changes in this population. Using a repeated cross-sectional study design, we measured rates of depression using the Patient Health Questionnaire-2 and anxiety using the Generalized Anxiety Disorder-2 scale in student-athletes attending elite sport high schools in Sweden during the second wave of the pandemic (February 2021; n = 7021) and after all restrictions were lifted (February 2022; n = 6228). Depression among student-athletes decreased from 19.8% in 2021 to 17.8% in 2022 (p = .008, V = .026), while anxiety screening did not change significantly (17.4% to 18.4%, p > .05). Comparisons between classes across years revealed older students exhibited decreases in depressive symptoms, while younger cohorts experienced increases in symptoms of anxiety from 2021 to 2022. Logistic regressions revealed that being female, reporting poorer mental health due to COVID-19, and excessive worry over one's career in sports were significant predictors of both depression and anxiety screenings in 2022. Compared to times when sports participation was limited, the lifting of restrictions was associated with overall reduced levels of depression, but not anxiety.", "doi": "10.1080/02640414.2023.2241783", "pmid": "37527354", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:26:06.817Z", "modified": "2023-10-06T04:46:42.217Z"}, {"entity": "publication", "iuid": "9fe286063aa7428b9c72813afeff6bf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9fe286063aa7428b9c72813afeff6bf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9fe286063aa7428b9c72813afeff6bf3"}}, "title": "COVID-19 vaccine hesitancy among first-generation immigrants living in Sweden.", "authors": [{"family": "Svallfors", "given": "Signe", "initials": "S", "orcid": "0000-0002-8413-1731", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2f5b34aae664a159d64182ad0f6517c.json"}}, {"family": "Larsson", "given": "Elin C", "initials": "EC"}, {"family": "Puranen", "given": "Bi", "initials": "B"}, {"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM"}], "type": "journal article", "published": "2023-08-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": "33", "issue": "4", "pages": "687-694"}, "abstract": "In many countries, immigrants face higher risks of contracting and dying from COVID-19 compared with the native-born population. Moreover, their COVID-19 vaccination uptake tends to be lower. This study aimed to investigate COVID-19 vaccine hesitancy in relation to sociodemographic characteristics, COVID-19-related exposures and social values, norms and perceptions among first-generation immigrants in Sweden. Vaccine hesitancy is an important public health issue to ensure protection against vaccine-preventable mortality and morbidity.\r\n\r\nNation-wide representative data were collected by the Migrant World Values Survey. Descriptive and multinomial multivariate analyses were performed to analyze vaccine hesitancy among 2612 men and women aged \u226516 years.\r\n\r\nOne-quarter of the respondents expressed some degree of vaccine hesitancy; 5% said they would definitely not vaccinate, 7% probably not, 4% did not know and 7% did not want to answer. Young age, arriving to Sweden during the large migration wave in 2015, Eastern European origin, female gender, lower education and low trust in authorities, and less perceived benefits of vaccination were all significant determinants of vaccine hesitancy.\r\n\r\nThe results underscore the importance of trust in healthcare providers and government authorities. Additionally, the importance of providing adequate and targeted information about vaccination to groups who face the largest barriers to care, enabling informed decision-making about the benefits and risks of vaccination in relation to health risks. Given these health risks, it is crucial that government agencies and the health sector address the multiple social dimensions that shape the low vaccine uptake and, in turn, health equity.", "doi": "10.1093/eurpub/ckad073", "pmid": "37229599", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10395762"}, {"db": "pii", "key": "7179915"}], "notes": [], "created": "2023-10-04T05:09:41.008Z", "modified": "2023-10-04T06:05:56.142Z"}, {"entity": "publication", "iuid": "5a7add59b3cd4d1c9ddce8fc1b59912e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5a7add59b3cd4d1c9ddce8fc1b59912e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5a7add59b3cd4d1c9ddce8fc1b59912e"}}, "title": "Were cancer patients worse off than the general population during the COVID-19 pandemic? A population-based study from Norway, Denmark and Iceland during the pre-vaccination era.", "authors": [{"family": "Johansson", "given": "Anna L V", "initials": "ALV"}, {"family": "Skog", "given": "Anna", "initials": "A"}, {"family": "Johannesen", "given": "Tom B\u00f8rge", "initials": "TB"}, {"family": "Myklebust", "given": "Tor \u00c5ge", "initials": "T\u00c5"}, {"family": "Skovlund", "given": "Charlotte Wessel", "initials": "CW"}, {"family": "M\u00f8rch", "given": "Lina Steinrud", "initials": "LS"}, {"family": "Friis", "given": "S\u00f8ren", "initials": "S"}, {"family": "Gamborg", "given": "Mads", "initials": "M"}, {"family": "Kristiansen", "given": "Marnar Fr\u00ed\u00f0heim", "initials": "MF"}, {"family": "Pettersson", "given": "David", "initials": "D"}, {"family": "\u00d3lafsd\u00f3ttir", "given": "El\u00ednborg J", "initials": "EJ"}, {"family": "Birgisson", "given": "Helgi", "initials": "H"}, {"family": "Palsson", "given": "Runolfur", "initials": "R"}, {"family": "Eythorsson", "given": "Elias", "initials": "E"}, {"family": "Irenaeus", "given": "Sandra", "initials": "S"}, {"family": "Lambe", "given": "Mats", "initials": "M"}, {"family": "Ursin", "given": "Giske", "initials": "G"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "issn-l": null, "volume": "31", "issue": null, "pages": "100680"}, "abstract": "In a population-based setting, we investigated the risks of testing positive for SARS-CoV-2 and developing severe COVID-19 outcomes among cancer patients compared with the general population.\r\n\r\nIn nationwide cohorts, we identified all individuals in Norway, Denmark and Iceland who tested positive for SARS-CoV-2 or had a severe COVID-19 outcome (hospitalisation, intensive care, and death) from March until December 2020, using data from national health registries. We estimated standardised incidence ratios (SIRs) with 95% confidence intervals (CIs) comparing cancer patients with the general population.\r\n\r\nDuring the first wave of the pandemic, cancer patients in Norway and Denmark had higher risks of testing SARS-CoV-2 positive compared to the general population. Throughout 2020, recently treated cancer patients were more likely to test SARS-CoV-2 positive. In Iceland, cancer patients experienced no increased risk of testing positive. The risk of COVID-19-related hospitalisation was higher among cancer patients diagnosed within one year of hospitalisation (Norway: SIR = 2.43, 95% CI 1.89-3.09; Denmark: 2.23, 1.96-2.54) and within five years (Norway: 1.58, 1.35-1.83; Denmark: 1.54, 1.42-1.66). Risks were higher in recently treated cancer patients and in those diagnosed with haematologic malignancies, colorectal or lung cancer. Risks of COVID-19-related intensive care and death were higher among cancer patients.\r\n\r\nCancer patients were at increased risk of testing positive for SARS-CoV-2 during the first pandemic wave when testing availability was limited, while relative risks of severe COVID-19 outcomes remained increased in cancer patients throughout 2020. Recent cancer treatment and haematologic malignancy were the strongest risk factors.\r\n\r\nNordic Cancer Union.", "doi": "10.1016/j.lanepe.2023.100680", "pmid": "37547277", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10398597"}, {"db": "pii", "key": "S2666-7762(23)00099-6"}], "notes": [], "created": "2023-10-05T08:01:39.277Z", "modified": "2023-10-05T08:29:59.698Z"}, {"entity": "publication", "iuid": "be720cf5d37342279078fa4d9c77d8b5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be720cf5d37342279078fa4d9c77d8b5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be720cf5d37342279078fa4d9c77d8b5"}}, "title": "The kinetics of SARS-CoV-2 viremia in COVID-19 patients receiving remdesivir.", "authors": [{"family": "Krifors", "given": "Anders", "initials": "A", "orcid": "0000-0003-1230-0492", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea4a8b6ff4ab4b10915071a561af110e.json"}}, {"family": "Karlsson", "given": "Linda", "initials": "L"}, {"family": "Ekman", "given": "Martin", "initials": "M"}, {"family": "Lorant", "given": "Camilla", "initials": "C"}, {"family": "Skorup", "given": "Paul", "initials": "P"}], "type": "observational study", "published": "2023-08-00", "journal": {"title": "Eur J Clin Microbiol Infect Dis", "issn": "1435-4373", "issn-l": null, "volume": "42", "issue": "8", "pages": "951-958"}, "abstract": "Detection of SARS-CoV-2 RNA in serum, viremia, has been linked to disease severity and outcome. The kinetics of viremia in patients receiving remdesivir has not been thoroughly studied and could help predict treatment response and outcome. We investigated the kinetics of SARS-CoV-2 viremia and factors associated with baseline viremia, viral clearance and 30-day mortality in patients receiving remdesivir. An observational study including 378 hospitalised patients (median age 67 years, 67% male) sampled with serum SARS-CoV-2 RT-PCR within \u00b1 24 h of initiation of remdesivir treatment. Baseline viremia was present in 206 (54%) patients with a median Ct value of 35.3 (IQR = 33.3-37.1). In patients with baseline viremia, the estimated probability of viral clearance was 72% by day 5. Ct values decreased significantly during remdesivir treatment for viremic patients, indicating an increase in viral load. In total, 44 patients (12%) died within 30 days, and mortality was significantly associated with viremia at baseline (OR = 2.45, p = 0.01) and lack of viral clearance by day 5 (OR = 4.8, p = < 0.01). Viral clearance was not associated with any individual risk factor. Viremia appears to be a prognostic marker before and during remedesivir treatment. The resolution of viremia was similar to patients not receiving remdesivir in other studies, and the decrease in Ct values during treatment questions the antiviral capacity of remdesivir in vivo. Prospective studies are warranted to confirm our findings.", "doi": "10.1007/s10096-023-04627-4", "pmid": "37243828", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10224642"}, {"db": "pii", "key": "10.1007/s10096-023-04627-4"}], "notes": [], "created": "2023-10-04T05:11:26.703Z", "modified": "2023-10-04T07:12:25.753Z"}, {"entity": "publication", "iuid": "79763b12a76d49b1b9f24d19c77829db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79763b12a76d49b1b9f24d19c77829db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79763b12a76d49b1b9f24d19c77829db"}}, "title": "Spontaneous Resolution of Uncomplicated Appendicitis may Explain Increase in Proportion of Complicated Appendicitis During Covid-19 Pandemic: a Systematic Review and Meta-analysis.", "authors": [{"family": "Andersson", "given": "Roland E", "initials": "RE", "orcid": "0000-0002-1460-0248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/63ebde95890245d58691f0d69acbbcc5.json"}}, {"family": "Agiorgiti", "given": "Maria", "initials": "M"}, {"family": "Bendtsen", "given": "Marcus", "initials": "M"}], "type": "meta-analysis", "published": "2023-08-00", "journal": {"title": "World J Surg", "issn": "1432-2323", "issn-l": null, "volume": "47", "issue": "8", "pages": "1901-1916"}, "abstract": "Reports of an increased proportion of complicated appendicitis during the Covid-19 pandemic suggest a worse outcome due to delay secondary to the restrained access to health care, but may be explained by a concomitant decrease in uncomplicated appendicitis. We analyze the impact of the pandemic on the incidences of complicated and uncomplicated appendicitis.\r\n\r\nWe did a systematic literature search in the PubMed, Embase and Web Of Science databases on December 21, 2022 with the search terms (appendicitis OR appendectomy) AND (\"COVID\" OR SARS-Cov2 OR \"coronavirus\"). Studies reporting the number of complicated and uncomplicated appendicitis during identical calendar periods in 2020 and the pre-pandemic year(s) were included. Reports with indications suggesting a change in how the patients were diagnosed and managed between the two periods were excluded. No protocol was prepared in advance. We did random effects meta-analysis of the change in proportion of complicated appendicitis, expressed as the risk ratio (RR), and of the change in number of patients with complicated and uncomplicated appendicitis during the pandemic compared with pre-pandemic periods, expressed as the incidence ratio (IR). We did separate analyses for studies based on single- and multi-center and regional data, age-categories and prehospital delay.\r\n\r\nThe meta-analysis of 100,059 patients in 63 reports from 25 countries shows an increase in the proportion of complicated appendicitis during the pandemic period (RR 1.39, 95% confidence interval (95% CI 1.25, 1.53). This was mainly explained by a decreased incidence of uncomplicated appendicitis (incidence ratio (IR) 0.66, 95% CI 0.59, 0.73). No increase in complicated appendicitis was seen in multi-center and regional reports combined (IR 0.98, 95% CI 0.90, 1.07).\r\n\r\nThe increased proportion of complicated appendicitis during Covid-19 is explained by a decrease in the incidence of uncomplicated appendicitis, whereas the incidence of complicated appendicitis remained stable. This result is more evident in the multi-center and regional based reports. This suggests an increase in spontaneously resolving appendicitis due to the restrained access to health care. This has important principal implications for the management of patients with suspected appendicitis.", "doi": "10.1007/s00268-023-07027-z", "pmid": "37140609", "labels": {"Category: Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC10158710"}, {"db": "pii", "key": "10.1007/s00268-023-07027-z"}], "notes": [], "created": "2023-10-04T05:11:43.715Z", "modified": "2023-10-04T07:21:04.378Z"}, {"entity": "publication", "iuid": "5f91d408d52142f4b03f19b0f95c8e51", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f91d408d52142f4b03f19b0f95c8e51.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f91d408d52142f4b03f19b0f95c8e51"}}, "title": "Revisiting the personal protective equipment components of transmission-based precautions for the prevention of COVID-19 and other respiratory virus infections in healthcare.", "authors": [{"family": "Plachouras", "given": "Diamantis", "initials": "D"}, {"family": "Kacelnik", "given": "Oliver", "initials": "O"}, {"family": "Rodr\u00edguez-Ba\u00f1o", "given": "Jes\u00fas", "initials": "J"}, {"family": "Birgand", "given": "Gabriel", "initials": "G"}, {"family": "Borg", "given": "Michael A", "initials": "MA"}, {"family": "Kristensen", "given": "Brian", "initials": "B"}, {"family": "Kubele", "given": "Jan", "initials": "J"}, {"family": "Lyytik\u00e4inen", "given": "Outi", "initials": "O"}, {"family": "Presterl", "given": "Elisabeth", "initials": "E"}, {"family": "Reilly", "given": "Jacqui", "initials": "J"}, {"family": "Voss", "given": "Andreas", "initials": "A"}, {"family": "Zingg", "given": "Walter", "initials": "W"}, {"family": "Suetens", "given": "Carl", "initials": "C"}, {"family": "Monnet", "given": "Dominique L", "initials": "DL"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "32", "pages": null}, "abstract": "The COVID-19 pandemic highlighted some potential limitations of transmission-based precautions. The distinction between transmission through large droplets vs aerosols, which have been fundamental concepts guiding infection control measures, has been questioned, leading to considerable variation in expert recommendations on transmission-based precautions for COVID-19. Furthermore, the application of elements of contact precautions, such as the use of gloves and gowns, is based on low-quality and inconclusive evidence and may have unintended consequences, such as increased incidence of healthcare-associated infections and spread of multidrug-resistant organisms. These observations indicate a need for high-quality studies to address the knowledge gaps and a need to revisit the theoretical background regarding various modes of transmission and the definitions of terms related to transmission. Further, we should examine the implications these definitions have on the following components of transmission-based precautions: (i) respiratory protection, (ii) use of gloves and gowns for the prevention of respiratory virus infections, (iii) aerosol-generating procedures and (iv) universal masking in healthcare settings as a control measure especially during seasonal epidemics. Such a review would ensure that transmission-based precautions are consistent and rationally based on available evidence, which would facilitate decision-making, guidance development and training, as well as their application in practice.", "doi": "10.2807/1560-7917.ES.2023.28.32.2200718", "pmid": "37561052", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10416576"}], "notes": [], "created": "2023-10-05T08:26:43.514Z", "modified": "2023-10-06T05:04:46.750Z"}, {"entity": "publication", "iuid": "ec036f75d2c84f21a9062b37be23a7bc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec036f75d2c84f21a9062b37be23a7bc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec036f75d2c84f21a9062b37be23a7bc"}}, "title": "Relative effectiveness of bivalent Original/Omicron BA.4-5 mRNA vaccine in preventing severe COVID-19 in persons 60 years and above during SARS-CoV-2 Omicron XBB.1.5 and other XBB sublineages circulation, Italy, April to June 2023.", "authors": [{"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Sacco", "given": "Chiara", "initials": "C"}, {"family": "Rota", "given": "Maria Cristina", "initials": "MC"}, {"family": "Fotakis", "given": "Emmanouil Alexandros", "initials": "EA"}, {"family": "Petrone", "given": "Daniele", "initials": "D"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Siddu", "given": "Andrea", "initials": "A"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Rezza", "given": "Giovanni", "initials": "G"}, {"family": "Palamara", "given": "Anna Teresa", "initials": "AT"}, {"family": "Brusaferro", "given": "Silvio", "initials": "S"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Italian Integrated Surveillance of COVID-19 study group and of the Italian COVID-19 Vaccines Registry group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "32", "pages": null}, "abstract": "During predominant circulation of SARS-CoV-2 Omicron XBB.1.5 and other XBB sublineages (April-June 2023), we found that a second or third booster of Comirnaty bivalent Original/Omicron BA.4-5 mRNA vaccine, versus a first booster received at least 120 days earlier, was effective in preventing severe COVID-19 for more than 6 months post-administration in persons 60 years and above. In view of autumn 2023 vaccination campaigns, use of bivalent Original/Omicron BA.4-5 mRNA vaccines might be warranted until monovalent COVID-19 vaccines targeting Omicron XBB.1 sublineages become available.", "doi": "10.2807/1560-7917.ES.2023.28.32.2300397", "pmid": "37561053", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10416574"}], "notes": [], "created": "2023-10-05T08:01:48.314Z", "modified": "2023-10-05T08:35:00.591Z"}, {"entity": "publication", "iuid": "60c4d930bc3a4ff78361a04cabad8596", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60c4d930bc3a4ff78361a04cabad8596.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60c4d930bc3a4ff78361a04cabad8596"}}, "title": "Real-world assessment of immunogenicity in immunocompromised individuals following SARS-CoV-2 mRNA vaccination: a one-year follow-up of the prospective clinical trial COVAXID.", "authors": [{"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Mielke", "given": "Stephan", "initials": "S"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "S\u00f6derdahl", "given": "Gunnar", "initials": "G"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE"}, {"family": "Vesterbacka", "given": "Jan", "initials": "J"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": "94", "issue": null, "pages": "104700"}, "abstract": "Immunocompromised patients have varying responses to SARS-CoV-2 mRNA vaccination. However, there is limited information available from prospective clinical trial cohorts with respect to long-term immunogenicity-related responses in these patient groups following three or four vaccine doses, and in applicable cases infection.\r\n\r\nIn a real-world setting, we assessed the long-term immunogenicity-related responses in patients with primary and secondary immunodeficiencies from the prospective open-label clinical trial COVAXID. The original clinical trial protocol included two vaccine doses given on days 0 and 21, with antibody titres measured at six different timepoints over six months. The study cohort has subsequently been followed for one year with antibody responses evaluated in relation to the third and fourth vaccine dose, and in applicable cases SARS-CoV-2 infection. In total 356/539 patients were included in the extended cohort. Blood samples were analysed for binding antibody titres and neutralisation against the Spike protein for all SARS-CoV-2 variants prevailing during the study period, including Omicron subvariants. SARS-CoV-2 infections that did not require hospital care were recorded through quarterly in-person, or phone-, interviews and assessment of IgG antibody titres against SARS-CoV-2 Nucleocapsid. The original clinical trial was registered in EudraCT (2021-000175-37) and clinicaltrials.gov (NCT04780659).\r\n\r\nThe third vaccine dose significantly increased Spike IgG titres against all the SARS-CoV-2 variants analysed in all immunocompromised patient groups. Similarly, neutralisation also increased against all variants studied, except for Omicron. Omicron-specific neutralisation, however, increased after a fourth dose as well as after three doses and infection in many of the patient subgroups. Noteworthy, however, while many patient groups mounted strong serological responses after three and four vaccine doses, comparably weak responders were found among patient subgroups with specific primary immunodeficiencies and subgroups with immunosuppressive medication.\r\n\r\nThe study identifies particularly affected patient groups in terms of development of long-term immunity among a larger group of immunocompromised patients. In particular, the results highlight poor vaccine-elicited neutralising responses towards Omicron subvariants in specific subgroups. The results provide additional knowledge of relevance for future vaccination strategies.\r\n\r\nThe present studies were supported by grants from the Swedish Research Council, the Knut and Alice Wallenberg Foundation, Nordstjernan AB, Region Stockholm, and Karolinska Institutet.", "doi": "10.1016/j.ebiom.2023.104700", "pmid": "37453361", "labels": {"Funder: VR": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10365982"}, {"db": "pii", "key": "S2352-3964(23)00265-7"}, {"db": "ClinicalTrials.gov", "key": "NCT04780659"}], "notes": [], "created": "2023-10-04T12:09:39.916Z", "modified": "2023-10-04T13:00:45.794Z"}, {"entity": "publication", "iuid": "d860da70e0254d6caaa6e69953ce5b58", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d860da70e0254d6caaa6e69953ce5b58.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d860da70e0254d6caaa6e69953ce5b58"}}, "title": "Protection against COVID-19 hospitalisation conferred by primary-series vaccination with AZD1222 in non-boosted individuals: first vaccine effectiveness results of the European COVIDRIVE study and meta-regression analysis.", "authors": [{"family": "Meeraus", "given": "Wilhelmine", "initials": "W"}, {"family": "de Munter", "given": "Leonie", "initials": "L"}, {"family": "Gray", "given": "Christen M", "initials": "CM"}, {"family": "Dwivedi", "given": "Akshat", "initials": "A"}, {"family": "Wyndham-Thomas", "given": "Chlo\u00e9", "initials": "C"}, {"family": "Ouwens", "given": "Mario", "initials": "M"}, {"family": "Hartig-Merkel", "given": "Wendy", "initials": "W"}, {"family": "Drikite", "given": "Laura", "initials": "L"}, {"family": "Rebry", "given": "Griet", "initials": "G"}, {"family": "Carmona", "given": "Antonio", "initials": "A"}, {"family": "Stuurman", "given": "Anke L", "initials": "AL"}, {"family": "Chi Nguyen", "given": "Thi Yen", "initials": "TY"}, {"family": "Mena", "given": "Guillermo", "initials": "G"}, {"family": "Mira-Iglesias", "given": "Ainara", "initials": "A"}, {"family": "Icardi", "given": "Giancarlo", "initials": "G"}, {"family": "Otero-Romero", "given": "Susana", "initials": "S"}, {"family": "Baumgartner", "given": "Sebastian", "initials": "S"}, {"family": "Martin", "given": "Charlotte", "initials": "C"}, {"family": "Taylor", "given": "Sylvia", "initials": "S"}, {"family": "Bollaerts", "given": "Kaatje", "initials": "K"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "issn-l": null, "volume": "31", "issue": null, "pages": "100675"}, "abstract": "Vaccine effectiveness (VE) studies with long-term follow-up are needed to understand durability of protection against severe COVID-19 outcomes conferred by primary-series vaccination in individuals not receiving boosters. COVIDRIVE is a European public-private partnership evaluating brand-specific vaccine effectiveness (VE). We report a prespecified interim analysis of primary-series AZD1222 (ChAdOx1 nCoV-19) VE.\r\n\r\nSeven Study Contributors in Europe collected data on individuals aged \u226518 years who were hospitalised with severe acute respiratory infection (June 1st, 2021-September 5th, 2022) and eligible for COVID-19 vaccination prior to hospitalisation. In this test-negative case-control study, individuals were defined as test-positive cases or test-negative controls (SARS-CoV-2 RT-PCR) and were either fully vaccinated (two AZD1222 doses, 4-12 weeks apart, completed \u226514 days prior to symptom onset; no booster doses) or unvaccinated (no COVID-19 vaccine prior to hospitalisation). The primary objective was to estimate AZD1222 VE against COVID-19 hospitalisation. A literature review and meta-regression were conducted to contextualise findings on durability of protection.\r\n\r\n761 individuals were included during the 15-month analysis period. Overall AZD1222 VE estimate was 72.8% (95% CI, 53.4-84.1). VE was 93.8% (48.6-99.3) in participants who received second AZD1222 doses \u22648 weeks prior to hospitalisation, with spline-based VE estimates demonstrating protection (VE \u2265 50%) 30 weeks post-second dose. Meta-regression analysis (data from seven publications) showed consistent results, with \u226580% protection against COVID-19 hospitalisation through \u223c43 weeks post-second dose, with some degree of waning.\r\n\r\nPrimary-series AZD1222 vaccination confers protection against COVID-19 hospitalisation with enduring levels of VE through \u22656 months.\r\n\r\nAstraZeneca.", "doi": "10.1016/j.lanepe.2023.100675", "pmid": "37547274", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10398604"}, {"db": "pii", "key": "S2666-7762(23)00094-7"}], "notes": [], "created": "2023-10-05T08:02:31.126Z", "modified": "2023-10-05T08:45:16.573Z"}, {"entity": "publication", "iuid": "6aff3364f8b246b88231e72ccb1373f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6aff3364f8b246b88231e72ccb1373f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6aff3364f8b246b88231e72ccb1373f2"}}, "title": "Professional ethics for infectious disease control: moral conflict management in modern public health practice.", "authors": [{"family": "Timpka", "given": "Toomas", "initials": "T"}, {"family": "Nyce", "given": "James M", "initials": "JM"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Public Health", "issn": "1476-5616", "issn-l": null, "volume": "221", "issue": null, "pages": "160-165"}, "abstract": "Despite scientific evidence that confirms their effectiveness, use of vaccines and microbiological mass testing during the COVID-19 pandemic has been associated with social and moral controversies. In this commentary, it is suggested how such conflicts originating from moral/normative imperatives can be managed in infectious disease control.\r\n\r\nThis was a commentary analysis.\r\n\r\nA case example of scientific and public debate regarding infectious disease control and policy-making during the early pandemic response is first presented. The case is used to characterize how conflicts arising from moral constraints occurred during the COVID-19 pandemic. These features are thereafter used as a basis for outlining a strategy for moral conflict prevention and management.\r\n\r\nA challenge for infectious disease control throughout the pandemic was how to manage persuasive initiatives originating from social forces competing with science for influence. Purposively maneuvered information distributed through social media and internet websites could predispose population factions to contest legitimate (evidence and legally based) pandemic response measures. During the pandemic, fact-based criticism of professionals responsible for infectious disease control was mixed with a critique of their moral standards and intentions so as to diminish effectiveness and credibility. Such blending could be curtailed if infectious disease control professionals are made accountable for public health decisions made in the light of prevalent scientific evidence and legislation.\r\n\r\nIf the infectious disease control community would embrace the international code of medical professional ethics, this would help to deal with moral conflicts, especially ones arising from external threats, in modern public health.", "doi": "10.1016/j.puhe.2023.06.017", "pmid": "37463550", "labels": {"Funder: VR": null, "Category: Health": null, "Category: Public Health": null, "Category: Vaccines": null, "Type: Review": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0033-3506(23)00206-8"}], "notes": [], "created": "2023-10-04T12:09:56.263Z", "modified": "2023-10-04T13:05:52.361Z"}, {"entity": "publication", "iuid": "d73e293cf7c34f7c9502549f02659114", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d73e293cf7c34f7c9502549f02659114.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d73e293cf7c34f7c9502549f02659114"}}, "title": "Prevalence of COVID-19 vaccine acceptance among migrant and refugee groups: A systematic review and meta-analysis.", "authors": [{"family": "Alimoradi", "given": "Zainab", "initials": "Z"}, {"family": "Sallam", "given": "Malik", "initials": "M"}, {"family": "Jafari", "given": "Elahe", "initials": "E"}, {"family": "Potenza", "given": "Marc N", "initials": "MN"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Vaccine X", "issn": "2590-1362", "issn-l": null, "volume": "14", "issue": null, "pages": "100308"}, "abstract": "Understanding COVID-19 vaccine hesitancy among migrant and refugee groups is critical for achieving vaccine equity. Therefore, we aimed to estimate the prevalence of COVID-19 vaccine acceptance among migrant and refugee populations.\r\n\r\nA systematic review (PROSPERO: CRD42022333337) was conducted (December 2019-July 2022) using PubMed, Scopus, Web of Science, ProQuest and Google Scholar.\r\n\r\nNineteen studies from 12 countries were included. The pooled estimated prevalence of COVID-19 vaccine willingness among migrant and refugee groups was 70% (19 studies, 95% CI: 62.3-77.4%, I2: 99.19%, \u03c42: 0.03). Female and male participants did not differ significantly with each other (p = 0.64). Although no individual variable contributed statistically significantly in multivariable meta-regression analysis, the multivariable model that considered methodological quality, mean age of participants, participant group and country of origin explained 67% of variance.\r\n\r\nProportions of migrant/refugee groups receiving COVID-19 vaccinations approximated those observed among general populations. Additional studies are needed to examine factors relating to vaccine willingness to identify the most significant factors that may be targeted in interventions.", "doi": "10.1016/j.jvacx.2023.100308", "pmid": "37223070", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10163798"}, {"db": "pii", "key": "S2590-1362(23)00049-9"}], "notes": [], "created": "2023-10-04T05:10:36.538Z", "modified": "2023-10-04T06:46:36.308Z"}, {"entity": "publication", "iuid": "ccc94b53992b4ba1aed223a6e2656d3e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ccc94b53992b4ba1aed223a6e2656d3e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ccc94b53992b4ba1aed223a6e2656d3e"}}, "title": "Local and Systemic Immunity During Five Vaccinations Against SARS-CoV-2 in Zanubrutinib-Treated Patients With Chronic Lymphocytic Leukemia.", "authors": [{"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Wu", "given": "Jinghua", "initials": "J"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Aberg", "given": "Mikael", "initials": "M"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "Naud", "given": "Sabrina", "initials": "S"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Palma", "given": "Marzia", "initials": "M"}, {"family": "Mellstedt", "given": "Hakan", "initials": "H"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Sallberg Chen", "given": "Margaret", "initials": "M"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Ingelman-Sundberg", "given": "Hanna M", "initials": "HM"}, {"family": "Osterborg", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "J Hematol", "issn": "1927-1220", "issn-l": null, "volume": "12", "issue": "4", "pages": "170-175"}, "abstract": "Patients with chronic lymphocytic leukemia (CLL) are vulnerable to coronavirus disease 2019 (COVID-19) and are at risk of inferior response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination, especially if treated with the first-generation Bruton's tyrosine kinase inhibitor (BTKi) ibrutinib. We aimed to evaluate the impact of the third-generation BTKi, zanubrutinib, on systemic and mucosal response to SARS-CoV-2 vaccination.\r\n\r\nNine patients with CLL with ongoing zanubrutinib therapy were included and donated blood and saliva during SARS-CoV-2 vaccination, before vaccine doses 3 and 5 and 2 - 3 weeks after doses 3, 4, and 5. Ibrutinib-treated control patients (n = 7) and healthy aged-matched controls (n = 7) gave blood 2 - 3 weeks after vaccine dose 5. We quantified reactivity and neutralization capacity of SARS-CoV-2-specific IgG and IgA antibodies (Abs) in both serum and saliva, and reactivity of T cells activated with viral peptides.\r\n\r\nBoth zanubrutinib- and ibrutinib-treated patients had significantly, up to 1,000-fold, lower total spike-specific Ab levels after dose 5 compared to healthy controls (P < 0.01). Spike-IgG levels in serum from zanubrutinib-treated patients correlated well to neutralization capacity (r = 0.68; P < 0.0001) and were thus functional. Mucosal immunity (specific IgA in serum and saliva) was practically absent in zanubrutinib-treated patients even after five vaccine doses, whereas healthy controls had significantly higher levels (tested in serum after vaccine dose 5) (P < 0.05). In contrast, T-cell reactivity against SARS-CoV-2 peptides was equally high in zanubrutinib- and ibrutinib-treated patients as in healthy control donors.\r\n\r\nIn our small cohort of zanubrutinib-treated CLL patients, we conclude that up to five doses of SARS-CoV-2 vaccination induced no detectable IgA mucosal immunity, which likely will impair the primary barrier defence against the infection. Systemic IgG responses were also impaired, whereas T-cell responses were normal. Further and larger studies are needed to evaluate the impact of these findings on disease protection.", "doi": "10.14740/jh1140", "pmid": "37692865", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10482612"}], "notes": [], "created": "2023-10-06T06:52:48.781Z", "modified": "2023-10-06T09:56:27.790Z"}, {"entity": "publication", "iuid": "12974aeee56640e7b04a0fe610c40f4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/12974aeee56640e7b04a0fe610c40f4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/12974aeee56640e7b04a0fe610c40f4c"}}, "title": "Living alone and mental health: parallel analyses in UK longitudinal population surveys and electronic health records prior to and during the COVID-19 pandemic.", "authors": [{"family": "McElroy", "given": "Eoin", "initials": "E", "orcid": "0000-0001-5466-8522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf4d10d067cd401896f2e1d5d5407f41.json"}}, {"family": "Herrett", "given": "Emily", "initials": "E", "orcid": "0000-0002-9425-644X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff5906d75a654724bba356031a4394e8.json"}}, {"family": "Patel", "given": "Kishan", "initials": "K", "orcid": "0000-0002-5693-6831", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4edb8e82fdf4c60874bad3eb9ceb6bc.json"}}, {"family": "Piehlmaier", "given": "Dominik M", "initials": "DM", "orcid": "0000-0003-0229-7007", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3957625c2ee04099a46f9b34334516d9.json"}}, {"family": "Gessa", "given": "Giorgio Di", "initials": "GD", "orcid": "0000-0001-6154-1845", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c2319c222cc40069a5f55ead6d361f6.json"}}, {"family": "Huggins", "given": "Charlotte", "initials": "C", "orcid": "0000-0001-5960-4771", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a02a696d498246b78636287e668394c8.json"}}, {"family": "Green", "given": "Michael J", "initials": "MJ", "orcid": "0000-0003-3193-2452", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84efba4af3264153b510906d0f4dcb35.json"}}, {"family": "Kwong", "given": "Alex S F", "initials": "ASF", "orcid": "0000-0003-1953-2771", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65ccb94351224dbdbcaa53d6ef6502ba.json"}}, {"family": "Thompson", "given": "Ellen J", "initials": "EJ", "orcid": "0000-0003-2118-821X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6754739394b24a5c8f5db22905b22c3c.json"}}, {"family": "Zhu", "given": "Jingmin", "initials": "J", "orcid": "0000-0001-8325-7589", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2ea57fd9f164a4687613cc7692ec378.json"}}, {"family": "Mansfield", "given": "Kathryn E", "initials": "KE"}, {"family": "Silverwood", "given": "Richard J", "initials": "RJ", "orcid": "0000-0002-2744-1194", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d46ad9468444d3dbfbe8f392b9fb502.json"}}, {"family": "Mansfield", "given": "Rosie", "initials": "R"}, {"family": "Maddock", "given": "Jane", "initials": "J", "orcid": "0000-0002-7975-4221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96323411c0b4423bb94776fea40f3f79.json"}}, {"family": "Mathur", "given": "Rohini", "initials": "R", "orcid": "0000-0002-3817-8790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/413a53b2b6734b6983ce583bf8ae9849.json"}}, {"family": "Costello", "given": "Ruth E", "initials": "RE", "orcid": "0000-0003-2709-6666", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c0fe69f61b54ab89f9a3de852f872a8.json"}}, {"family": "Matthews", "given": "Anthony", "initials": "A"}, {"family": "Tazare", "given": "John", "initials": "J", "orcid": "0000-0002-7194-2615", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/edd71baff18241099ed99c9770b9aad6.json"}}, {"family": "Henderson", "given": "Alasdair", "initials": "A", "orcid": "0000-0002-8903-4906", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/136c2cef770547d9a777c334746755a7.json"}}, {"family": "Wing", "given": "Kevin", "initials": "K", "orcid": "0000-0003-2335-9641", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a5697cdb0ed469091230d744f22a31c.json"}}, {"family": "Bridges", "given": "Lucy", "initials": "L", "orcid": "0000-0002-4407-9596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07faf17819de4a219027db6f265bad97.json"}}, {"family": "Bacon", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-6354-3454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6616a304a007470e8fce5b54c5874156.json"}}, {"family": "Mehrkar", "given": "Amir", "initials": "A", "orcid": "0000-0002-2098-1278", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee1d683bf7114dc8a4deace10b1cd4ce.json"}}, {"family": "OpenSAFELY Collaborative", "given": "", "initials": ""}, {"family": "Shaw", "given": "Richard John", "initials": "RJ", "orcid": "0000-0002-7906-6066", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e70bea99a7b44fbeaa9841571db846a3.json"}}, {"family": "Wels", "given": "Jacques", "initials": "J", "orcid": "0000-0002-9292-917X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03eb758b02f04c3583536497f996ea68.json"}}, {"family": "Katikireddi", "given": "Srinivasa Vittal", "initials": "SV", "orcid": "0000-0001-6593-9092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9bcdfb6c28e742878e7df8ee66fa6863.json"}}, {"family": "Chaturvedi", "given": "Nish", "initials": "N", "orcid": "0000-0002-6211-2775", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94889a94593342f688fc89e9419ef7d0.json"}}, {"family": "Tomlinson", "given": "Laurie A", "initials": "LA", "orcid": "0000-0001-8848-9493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03f2034f701e46f3919a944d2ac325d7.json"}}, {"family": "Patalay", "given": "Praveetha", "initials": "P", "orcid": "0000-0002-5341-3461", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c768af96078f4a0f9dc121d07bef6f81.json"}}, {"family": "Longitudinal Health and Wellbeing Collaborative", "given": "", "initials": ""}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "BMJ Ment Health", "issn": "2755-9734", "issn-l": null, "volume": "26", "issue": "1", "pages": null}, "abstract": "People who live alone experience greater levels of mental illness; however, it is unclear whether the COVID-19 pandemic had a disproportionately negative impact on this demographic.\r\n\r\nTo describe the mental health gap between those who live alone and with others in the UK prior to and during the COVID-19 pandemic.\r\n\r\nSelf-reported psychological distress and life satisfaction in 10 prospective longitudinal population surveys (LPSs) assessed in the nearest pre-pandemic sweep and three periods during the pandemic. Recorded diagnosis of common and severe mental illnesses between March 2018 and January 2022 in electronic healthcare records (EHRs) within the OpenSAFELY-TPP.\r\n\r\nIn 37 544 LPS participants, pooled models showed greater psychological distress (standardised mean difference (SMD): 0.09 (95% CI: 0.04; 0.14); relative risk: 1.25 (95% CI: 1.12; 1.39)) and lower life satisfaction (SMD: -0.22 (95% CI: -0.30; -0.15)) for those living alone pre-pandemic. This gap did not change during the pandemic. In the EHR analysis of c.16 million records, mental health conditions were more common in those who lived alone (eg, depression 26 (95% CI: 18 to 33) and severe mental illness 58 (95% CI: 54 to 62) more cases more per 100 000). For common mental health disorders, the gap in recorded cases in EHRs narrowed during the pandemic.\r\n\r\nPeople living alone have poorer mental health and lower life satisfaction. During the pandemic, this gap in self-reported distress remained; however, there was a narrowing of the gap in service use.\r\n\r\nGreater mental health need and potentially greater barriers to mental healthcare access for those who live alone need to be considered in healthcare planning.", "doi": "10.1136/bmjment-2023-300842", "pmid": "37562853", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pii", "key": "bmjment-2023-300842"}], "notes": [], "created": "2023-10-05T08:26:51.207Z", "modified": "2023-10-06T05:16:12.883Z"}, {"entity": "publication", "iuid": "fa914e711dd04aa88bad9970b0bea1f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa914e711dd04aa88bad9970b0bea1f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa914e711dd04aa88bad9970b0bea1f0"}}, "title": "Impact of asthma in Europe: A comparison of web search data in 21 European countries.", "authors": [{"family": "Wecker", "given": "Hannah", "initials": "H"}, {"family": "Tizek", "given": "Linda", "initials": "L"}, {"family": "Ziehfreund", "given": "Stefanie", "initials": "S"}, {"family": "Kain", "given": "Alphina", "initials": "A"}, {"family": "Traidl-Hoffmann", "given": "Claudia", "initials": "C"}, {"family": "Zimmermann", "given": "Gregor S", "initials": "GS"}, {"family": "Scala", "given": "Emanuele", "initials": "E"}, {"family": "Elberling", "given": "Jesper", "initials": "J"}, {"family": "Doll", "given": "Ana\u00efs", "initials": "A"}, {"family": "Boffa", "given": "Michael J", "initials": "MJ"}, {"family": "Schmidt", "given": "Lea", "initials": "L"}, {"family": "Sikora", "given": "Mariusz", "initials": "M"}, {"family": "Torres", "given": "Tiago", "initials": "T"}, {"family": "Ballardini", "given": "Natalia", "initials": "N"}, {"family": "Chernyshov", "given": "Pavel V", "initials": "PV"}, {"family": "Buters", "given": "Jeroen", "initials": "J"}, {"family": "Biedermann", "given": "Tilo", "initials": "T"}, {"family": "Zink", "given": "Alexander", "initials": "A"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "World Allergy Organ J", "issn": "1939-4551", "issn-l": "1939-4551", "volume": "16", "issue": "8", "pages": "100805"}, "abstract": "Asthma is a chronic inflammatory disorder of the airways and one of the most important non-communicable diseases worldwide. Analyzing crowdsourced data can help understand public interest and unmet needs as well as potential factors influencing search behavior.\r\n\r\nThe study aimed to investigate asthma-related web search data in Europe to identify possible regional and seasonal variations and to assess public interest.\r\n\r\nGoogle Ads Keyword Planner was used to measure search volume for search terms related to asthma, allergic asthma, and bronchial asthma in 21 European countries between January 2018 and December 2021. The top 10 keywords of each country were categorized qualitatively. Search volume per 100 000 inhabitants was descriptively assessed in terms of regional and seasonal trends. Spearman correlations between search volume and pollen concentration as well as coronavirus disease (COVID-19) cases were investigated.\r\n\r\nThe median search volume per 100 000 inhabitants for asthma and allergic asthma was highest in Northern and Western Europe, while the highest search volume for bronchial asthma was observed in Western and Eastern regions. A seasonal trend was identified for all search terms and in all regions. Correlations were found between search frequency and pollen load and search behavior and COVID-19 cases. Overall, Europeans were most interested in the diseases in general, their treatment options, and symptoms.\r\n\r\nThese results highlighted the need for reliable and region-specific information about the disease and for public campaigns to improve asthma control. The study also emphasizes the importance of using crowdsourced data for a more encompassing overview beyond conventional healthcare data.", "doi": "10.1016/j.waojou.2023.100805", "pmid": "37564904", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10410582"}, {"db": "pii", "key": "S1939-4551(23)00065-0"}], "notes": [], "created": "2023-10-05T08:26:40.891Z", "modified": "2023-10-06T05:03:14.211Z"}, {"entity": "publication", "iuid": "b0d93f664e8e4e268d06ed0166907d8a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b0d93f664e8e4e268d06ed0166907d8a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b0d93f664e8e4e268d06ed0166907d8a"}}, "title": "High Exposure to Perfluoroalkyl Substances and Antibody Responses to SARS-CoV-2 mRNA Vaccine-an Observational Study in Adults from Ronneby, Sweden.", "authors": [{"family": "Andersson", "given": "Axel G", "initials": "AG", "orcid": "0000-0002-1215-8433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/291ed3a52d1c470fad6855915a959b69.json"}}, {"family": "Lundgren", "given": "Anna", "initials": "A"}, {"family": "Xu", "given": "Yiyi", "initials": "Y"}, {"family": "Nielsen", "given": "Christel", "initials": "C"}, {"family": "Lindh", "given": "Christian H", "initials": "CH"}, {"family": "Pineda", "given": "Daniela", "initials": "D"}, {"family": "Cederlund", "given": "Julia", "initials": "J"}, {"family": "Pataridou", "given": "Elisavet", "initials": "E"}, {"family": "S\u00f8gaard T\u00f8ttenborg", "given": "Sandra", "initials": "S"}, {"family": "Ugelvig Petersen", "given": "Kajsa", "initials": "K"}, {"family": "Fletcher", "given": "Tony", "initials": "T"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Bemark", "given": "Mats", "initials": "M"}, {"family": "Jakobsson", "given": "Kristina", "initials": "K"}, {"family": "Li", "given": "Ying", "initials": "Y"}], "type": "observational study", "published": "2023-08-00", "journal": {"title": "Environ Health Perspect", "issn": "1552-9924", "issn-l": null, "volume": "131", "issue": "8", "pages": "87007"}, "abstract": "Per- and polyfluoroalkyl substances (PFAS) are widely used, environmentally ubiquitous, and stable chemicals that have been associated with lower vaccine-induced antibody responses in children; however, data on adults are limited. The drinking water from one of the two waterworks in Ronneby, Sweden, was heavily contaminated for decades with PFAS from firefighting foams, primarily perfluorohexane sulfonic acid and perfluorooctanesulfonic acid (PFOS). Vaccination against SARS-CoV-2 offered a unique opportunity to investigate antibody responses to primary vaccination in adults who had been exposed to PFAS.\r\n\r\nOur objective was to evaluate associations between PFAS, across a wide range of exposure levels, and antibody responses in adults 5 wk and 6 months after a two-dose vaccination regime against SARS-CoV-2.\r\n\r\nAdults age 20-60 y from Ronneby (, median PFOS serum level n=309, fifth to 95th percentile 47 ng/mL) and a group with background exposure (4-213 ng/mL, median PFOS serum level n=47) received two doses of the Spikevax (Moderna) mRNA vaccine. The levels of seven PFAS were measured in serum before vaccination. Serum immunoglobulin G antibodies against the SARS-CoV-2 spike antigen (S-Abs) were measured before vaccination and at 5 wk (4 ng/mL) and 6 months (n=350) after the second vaccine dose. Linear regression analyses were fitted against current, historical, and prenatal exposure to PFAS, adjusting for sex, age, and smoking, excluding individuals with previous SARS-CoV-2-infection.n=329\r\n\r\nPFAS exposure, regardless of how it was estimated, was not negatively associated with antibody levels 5 wk [current PFOS: S-Abs/PFOS interquartile range (IQR); 95% confidence interval (CI): -0.5%, 7] or 6 months (current PFOS: 3% S-Abs/PFOS IQR; 95% CI: -8, 12) after COVID-19 vaccination.-6\r\n\r\nFollowing a strict study protocol, rigorous study design, and few dropouts, we found no indication that PFAS exposure negatively affected antibody responses to COVID-19 mRNA vaccination for up to 6 months after vaccination. https://doi.org/10.1289/EHP11847.", "doi": "10.1289/EHP11847", "pmid": "37578904", "labels": {"Funder: Forte": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10424820"}, {"db": "EudraCT", "key": "2021-000842-16"}], "notes": [], "created": "2023-10-05T08:01:59.033Z", "modified": "2023-10-05T08:40:06.917Z"}, {"entity": "publication", "iuid": "5428e4b796a945bcafd9aee56df86839", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5428e4b796a945bcafd9aee56df86839.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5428e4b796a945bcafd9aee56df86839"}}, "title": "Food-related experiences and behavioral responses among people affected by chemosensory dysfunctions following COVID-19: A scoping review.", "authors": [{"family": "Neuman", "given": "Nicklas", "initials": "N", "orcid": "0000-0001-7970-4753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d135c1772d041e1af59c646a97ca9a0.json"}}, {"family": "Sandvik", "given": "Pernilla", "initials": "P"}, {"family": "Lindholm", "given": "Ninni Bellini", "initials": "NB"}, {"family": "B\u00f6mer-Schulte", "given": "Katharina", "initials": "K"}, {"family": "L\u00f6vestam", "given": "Elin", "initials": "E"}], "type": "review", "published": "2023-08-00", "journal": {"title": "Res Nurs Health", "issn": "1098-240X", "issn-l": null, "volume": "46", "issue": "4", "pages": "385-399"}, "abstract": "A category of symptoms that became characteristic early in the first wave of the coronavirus disease 2019 (COVID-19) pandemic was chemosensory dysfunctions (alterations of smell and taste). Such symptoms substantially affect food and eating-cornerstones for both nutrition-related health outcomes and for quality of life. Based on this, this scoping review aimed to map out existing scientific literature on food-related experiences and related behavioral responses among people affected by chemosensory dysfunctions following COVID-19. A librarian-supported search of PsycInfo, PubMed, and Scopus for publications written in English (2020 to April 26, 2022) was conducted. Two authors searched for and screened publications and three others extracted and collated data. These are reported following the Preferred Reporting Items of Systematic reviews and Meta-Analyses extension for Scoping Reviews. Of 1169 hits, 9 publications were included in the review. The results are thematized as \"Psychological and social aspects\" and \"Nutritional aspects,\" each with the subsections \"Experiences\" and \"Behavioral responses.\" A great variety of food-related problems, nutritional and mental health effects, and implications for social life are identified. People affected by chemosensory dysfunctions following COVID-19 suffer, as evident both in stories from qualitative studies and in measurements of quality of life. The results impact all professions who are and may come to be involved in treating these patients, such as nurses, physicians, dietitians, and psychologists. With more knowledge about the dysfunctions' manifestation, duration, and impact on everyday life, multiprofessional teams need to collaborate in supporting patients medically, psychosocially, and nutritionally.", "doi": "10.1002/nur.22315", "pmid": "37171788", "labels": {"Category: Health": null, "Type: Review": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:10:50.604Z", "modified": "2023-10-04T07:00:13.599Z"}, {"entity": "publication", "iuid": "4958e8848a3946d2be85f7443d18d7cd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4958e8848a3946d2be85f7443d18d7cd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4958e8848a3946d2be85f7443d18d7cd"}}, "title": "Effect of external dead space removal on CO2 homeostasis in mechanically ventilated adult Covid-19 patients.", "authors": [{"family": "\u00d6hman", "given": "Tomas", "initials": "T"}, {"family": "Jalde", "given": "Francesca Campoccia", "initials": "FC"}, {"family": "Fredby", "given": "Magnus", "initials": "M"}, {"family": "Bj\u00f6rne", "given": "H\u00e5kan", "initials": "H"}, {"family": "Karlsson", "given": "Jacob", "initials": "J", "orcid": "0000-0003-2277-0092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a428771f0dc41948d1d1e13131497bc.json"}}], "type": "observational study", "published": "2023-08-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": "67", "issue": "7", "pages": "936-942"}, "abstract": "Patients with Covid-19 respiratory failure present with hypoxemia, often in combination with hypercapnia. In this prospective, observational study we examined the effect of removing external dead space (DS) on CO2 -homeostasis in mechanically ventilated Covid-19 patients. In addition, volumetric capnography was validated for its ability to estimate external DS volume using in vitro measured DS volumes as reference.\r\n\r\nIn total, 10 patients with acute respiratory distress syndrome from Covid-19 were included. Volumetric capnography, mechanical ventilation, and arterial blood gas data were analyzed before and after removal of external DS and analyzed for potentially significant changes in response to DS removal. Measurements of external DS were obtained in circuit using volumetric capnography and compared to actual measured DS volumes off the circuit.\r\n\r\nAfter the removal of external DS, the alveolar minute ventilation and CO2 elimination improved, notwithstanding unchanged respiratory rate and tidal volumes. The increase in CO2 elimination was associated with a decrease in arterial CO2 partial pressure (PaCO2 ). The volumetric capnography method for assessment of external DS showed a low bias of -9 mL (lower limit of agreement -40, 95% CI -60 to -20 mL, upper limit of agreement 21 mL, 95% CI: 1-40 mL) and a percentage error of 48% compared to absolute values measured in vitro.\r\n\r\nRemoval of external DS increased alveolar minute ventilation and CO2 elimination in Covid-19 patients with respiratory failure in the current study. This was associated with a decrease in PaCO2 . This may indicate a decreased CO2 production due to decreased work of breathing and more effective gas-exchange in response to DS removal. In addition, volumetric capnography appears to be a clinically feasible method for continuous measurement of external DS in the current study and may be of value in optimizing ventilator treatment.", "doi": "10.1111/aas.14252", "pmid": "37354078", "labels": {"Category: Health": null, "Funder: Vinnova": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:31:09.191Z", "modified": "2023-10-04T10:44:03.243Z"}, {"entity": "publication", "iuid": "54c4d494ea0b4df8bacb49481ba454ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54c4d494ea0b4df8bacb49481ba454ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54c4d494ea0b4df8bacb49481ba454ff"}}, "title": "Echocardiography phenotypes of right ventricular involvement in COVID-19 ARDS patients and ICU mortality: post-hoc (exploratory) analysis of repeated data from the ECHO-COVID study.", "authors": [{"family": "Huang", "given": "Stephen", "initials": "S"}, {"family": "Vieillard-Baron", "given": "Antoine", "initials": "A"}, {"family": "Evrard", "given": "Bruno", "initials": "B", "orcid": "0000-0003-1829-4927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bba6533429b5415ab89299eda9c64d57.json"}}, {"family": "Prat", "given": "Gwena\u00ebl", "initials": "G"}, {"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Balik", "given": "Martin", "initials": "M"}, {"family": "Clau-Terr\u00e9", "given": "Fernando", "initials": "F"}, {"family": "De Backer", "given": "Daniel", "initials": "D"}, {"family": "Mekontso Dessap", "given": "Armand", "initials": "A"}, {"family": "Orde", "given": "Sam", "initials": "S"}, {"family": "Morelli", "given": "Andrea", "initials": "A"}, {"family": "Sanfilippo", "given": "Filippo", "initials": "F"}, {"family": "Charron", "given": "Cyril", "initials": "C"}, {"family": "Vignon", "given": "Philippe", "initials": "P", "orcid": "0000-0003-4551-5772", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9944b30a58047218e6e4cf59c3572b4.json"}}, {"family": "ECHO-COVID study group", "given": "", "initials": ""}], "type": "observational study", "published": "2023-08-00", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "issn-l": "0342-4642", "volume": "49", "issue": "8", "pages": "946-956"}, "abstract": "Exploratory study to evaluate the association of different phenotypes of right ventricular (RV) involvement and mortality in the intensive care unit (ICU) in patients with acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19).\r\n\r\nPost-hoc analysis of longitudinal data from the multicenter ECHO-COVID observational study in ICU patients who underwent at least two echocardiography examinations. Echocardiography phenotypes were acute cor pulmonale (ACP, RV cavity dilatation with paradoxical septal motion), RV failure (RVF, RV cavity dilatation and systemic venous congestion), and RV dysfunction (tricuspid annular plane systolic excursion \u2264 16 mm). Accelerated failure time model and multistate model were used for analysis.\r\n\r\nOf 281 patients who underwent 948 echocardiography studies during ICU stay, 189 (67%) were found to have at least 1 type of RV involvements during one or several examinations: ACP (105/281, 37.4%), RVF (140/256, 54.7%) and/or RV dysfunction (74/255, 29%). Patients with all examinations displaying ACP had survival time shortened by 0.479 [0.284-0.803] times when compared to patients with all examinations depicting no ACP (P = 0.005). RVF showed a trend towards shortened survival time by a factor of 0.642 [0.405-1.018] (P = 0.059), whereas the impact of RV dysfunction on survival time was inconclusive (P = 0.451). Multistate analysis showed that patients might transit in and out of RV involvement, and those who exhibited ACP in their last critical care echocardiography (CCE) examination had the highest risk of mortality (hazard ratio (HR) 3.25 [2.38-4.45], P < 0.001).\r\n\r\nRV involvement is prevalent in patients ventilated for COVID-19 ARDS. Different phenotypes of RV involvement might lead to different ICU mortality, with ACP having the worst outcome.", "doi": "10.1007/s00134-023-07147-z", "pmid": "37436445", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-023-07147-z"}, {"db": "ClinicalTrials.gov", "key": "NCT04414410"}], "notes": [], "created": "2023-10-04T12:10:45.208Z", "modified": "2023-10-04T13:30:45.479Z"}, {"entity": "publication", "iuid": "78855cf5737a471daf4bde2997a75b88", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/78855cf5737a471daf4bde2997a75b88.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/78855cf5737a471daf4bde2997a75b88"}}, "title": "Concordance between COVID-19 mortality statistics derived from clinical audit and death certificates in \u00d6sterg\u00f6tland county, Sweden.", "authors": [{"family": "Spreco", "given": "A", "initials": "A"}, {"family": "Andersson", "given": "C", "initials": "C"}, {"family": "Sj\u00f6dahl", "given": "R", "initials": "R"}, {"family": "Timpka", "given": "T", "initials": "T"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Public Health", "issn": "1476-5616", "issn-l": null, "volume": "221", "issue": null, "pages": "46-49"}, "abstract": "Despite early notions that correct attribution of deaths caused by SARS-CoV-2 infection is critical to the understanding of the COVID-19 pandemic, three years later, the accuracy of COVID-19 death counts is still contested. We aimed to compare official death statistics with cause-of-death assessments made in a clinical audit routine by experienced physicians having access to the full medical record.\r\n\r\nHealth service quality evaluation.\r\n\r\nIn \u00d6sterg\u00f6tland county (pop. 465,000), Sweden, a clinical audit team assessed from the start of the pandemic the cause of death in individuals having deceased after testing positive for SARS-CoV-2. We estimated the concordance between official data on COVID-19 deaths and data from the clinical audit using correlations (r) between the cause-of-death categories and discrepancies between the absolute numbers of categorised deaths.\r\n\r\nThe concordance between the data sources was poor regarding whether COVID-19 was the underlying or a contributing cause of death. Grouping of the causes increased the correlations to acceptable strength. Also including deaths implicated by a positive SARS-CoV-2 test in the clinical categorisation of COVID-19 deaths reduced the difference in absolute number of deaths; with these modifications, the concordance was acceptable before the COVID-19 vaccination program was initiated (r = 0.97; symmetric mean absolute percentage error (SMAPE) = 19%), while a difference in the absolute numbers of deaths remained in the vaccination period (r = 0.94; SMAPE = 35%).\r\n\r\nThis study highlights that carefulness is warranted when COVID-19 death statistics are used in health service planning and resonates a need for further research on cause-of-death recording methodologies.", "doi": "10.1016/j.puhe.2023.06.007", "pmid": "37399611", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10250145"}, {"db": "pii", "key": "S0033-3506(23)00196-8"}], "notes": [], "created": "2023-10-04T12:07:35.390Z", "modified": "2023-10-04T12:20:18.768Z"}, {"entity": "publication", "iuid": "03df4cb9fa074a96b65ad775b99372a7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/03df4cb9fa074a96b65ad775b99372a7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/03df4cb9fa074a96b65ad775b99372a7"}}, "title": "Collaborative nowcasting of COVID-19 hospitalization incidences in Germany.", "authors": [{"family": "Wolffram", "given": "Daniel", "initials": "D", "orcid": "0000-0003-0318-3669", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce85bc05765a499db19a3df6ec4c142b.json"}}, {"family": "Abbott", "given": "Sam", "initials": "S"}, {"family": "An der Heiden", "given": "Matthias", "initials": "M"}, {"family": "Funk", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-2842-3406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f03dcbc41884648a4eac5892852899a.json"}}, {"family": "G\u00fcnther", "given": "Felix", "initials": "F"}, {"family": "Hailer", "given": "Davide", "initials": "D"}, {"family": "Heyder", "given": "Stefan", "initials": "S"}, {"family": "Hotz", "given": "Thomas", "initials": "T"}, {"family": "van de Kassteele", "given": "Jan", "initials": "J"}, {"family": "K\u00fcchenhoff", "given": "Helmut", "initials": "H"}, {"family": "M\u00fcller-Hansen", "given": "S\u00f6ren", "initials": "S"}, {"family": "Syliqi", "given": "Diell\u00eb", "initials": "D"}, {"family": "Ullrich", "given": "Alexander", "initials": "A"}, {"family": "Weigert", "given": "Maximilian", "initials": "M", "orcid": "0000-0003-4400-134X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4022b7edbd404fa695f562f9fd78a051.json"}}, {"family": "Schienle", "given": "Melanie", "initials": "M"}, {"family": "Bracher", "given": "Johannes", "initials": "J", "orcid": "0000-0002-3777-1410", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/edf3423decee40a8835ae6475a141386.json"}}], "type": "case reports", "published": "2023-08-00", "journal": {"title": "PLoS Comput Biol", "issn": "1553-7358", "issn-l": null, "volume": "19", "issue": "8", "pages": "e1011394"}, "abstract": "Real-time surveillance is a crucial element in the response to infectious disease outbreaks. However, the interpretation of incidence data is often hampered by delays occurring at various stages of data gathering and reporting. As a result, recent values are biased downward, which obscures current trends. Statistical nowcasting techniques can be employed to correct these biases, allowing for accurate characterization of recent developments and thus enhancing situational awareness. In this paper, we present a preregistered real-time assessment of eight nowcasting approaches, applied by independent research teams to German 7-day hospitalization incidences during the COVID-19 pandemic. This indicator played an important role in the management of the outbreak in Germany and was linked to levels of non-pharmaceutical interventions via certain thresholds. Due to its definition, in which hospitalization counts are aggregated by the date of case report rather than admission, German hospitalization incidences are particularly affected by delays and can take several weeks or months to fully stabilize. For this study, all methods were applied from 22 November 2021 to 29 April 2022, with probabilistic nowcasts produced each day for the current and 28 preceding days. Nowcasts at the national, state, and age-group levels were collected in the form of quantiles in a public repository and displayed in a dashboard. Moreover, a mean and a median ensemble nowcast were generated. We find that overall, the compared methods were able to remove a large part of the biases introduced by delays. Most participating teams underestimated the importance of very long delays, though, resulting in nowcasts with a slight downward bias. The accompanying prediction intervals were also too narrow for almost all methods. Averaged over all nowcast horizons, the best performance was achieved by a model using case incidences as a covariate and taking into account longer delays than the other approaches. For the most recent days, which are often considered the most relevant in practice, a mean ensemble of the submitted nowcasts performed best. We conclude by providing some lessons learned on the definition of nowcasting targets and practical challenges.", "doi": "10.1371/journal.pcbi.1011394", "pmid": "37566642", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Other": null, "Funder: NordForsk": null}, "xrefs": [{"db": "pmc", "key": "PMC10446237"}, {"db": "pii", "key": "PCOMPBIOL-D-23-00600"}], "notes": [], "created": "2023-10-05T08:27:07.259Z", "modified": "2023-10-06T05:21:23.352Z"}, {"entity": "publication", "iuid": "280a86d0e27f4240af16b8cfe3cffbab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/280a86d0e27f4240af16b8cfe3cffbab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/280a86d0e27f4240af16b8cfe3cffbab"}}, "title": "Classification of \"Near-patient\" and \"Point-of-Care\" SARS-CoV-2 Nucleic Acid Amplification Test Systems and a first approach to evaluate their analytical independence of operator activities.", "authors": [{"family": "Buchta", "given": "Christoph", "initials": "C"}, {"family": "Zeichhardt", "given": "Heinz", "initials": "H"}, {"family": "Badrick", "given": "Tony", "initials": "T"}, {"family": "Coucke", "given": "Wim", "initials": "W"}, {"family": "Wojtalewicz", "given": "Nathalie", "initials": "N"}, {"family": "Griesmacher", "given": "Andrea", "initials": "A"}, {"family": "Aberle", "given": "Stephan W", "initials": "SW"}, {"family": "Schellenberg", "given": "Ingo", "initials": "I"}, {"family": "Jacobs", "given": "Ellis", "initials": "E"}, {"family": "Nordin", "given": "Gunnar", "initials": "G"}, {"family": "Schweiger", "given": "Christian", "initials": "C"}, {"family": "Schwenoha", "given": "Karin", "initials": "K"}, {"family": "Luppa", "given": "Peter B", "initials": "PB"}, {"family": "Gassner", "given": "Ulrich M", "initials": "UM"}, {"family": "Wagner", "given": "Thomas", "initials": "T"}, {"family": "Kammel", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "J Clin Virol", "issn": "1873-5967", "issn-l": null, "volume": "165", "issue": null, "pages": "105521"}, "abstract": "European legislation defines as \"near-patient testing\" (NPT) what is popularly and in other legislations specified as \"point-of-care testing\" (POCT). Systems intended for NPT/POCT use must be characterized by independence from operator activities during the analytic procedure. However, tools for evaluating this are lacking. We hypothesized that the variability of measurement results obtained from identical samples with a larger number of identical devices by different operators, expressed as the method-specific reproducibility of measurement results reported in External Quality Assessment (EQA) schemes, is an indicator for this characteristic.\r\n\r\nLegal frameworks in the EU, the USA and Australia were evaluated about their requirements for NPT/POCT. EQA reproducibility of seven SARS-CoV-2-NAAT systems, all but one designated as \"POCT\", was calculated from variabilities in Ct values obtained from the respective device types in three different EQA schemes for virus genome detection.\r\n\r\nA matrix for characterizing test systems based on their technical complexity and the required operator competence was derived from requirements of the European In Vitro Diagnostic Regulation (IVDR) 2017/746. Good EQA reproducibility of the measurement results of the test systems investigated implies that different users in different locations have no recognizable influence on their measurement results.\r\n\r\nThe fundamental suitability of test systems for NPT/POCT use according to IVDR can be easily verified using the evaluation matrix presented. EQA reproducibility is a specific characteristic indicating independence from operator activities of NPT/POCT assays. EQA reproducibility of other systems than those investigated here remains to be determined.", "doi": "10.1016/j.jcv.2023.105521", "pmid": "37302248", "labels": {"Category: Health": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10249340"}, {"db": "pii", "key": "S1386-6532(23)00144-0"}], "notes": [], "created": "2023-10-04T09:33:21.018Z", "modified": "2023-10-04T11:24:26.997Z"}, {"entity": "publication", "iuid": "fe5a3c1f5a5b4f54978442d6e30d165e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fe5a3c1f5a5b4f54978442d6e30d165e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fe5a3c1f5a5b4f54978442d6e30d165e"}}, "title": "Certified Registered Nurse Anesthetists' Experience of Relocation to COVID-19 Intensive Care-A Qualitative Interview Study.", "authors": [{"family": "Sundblad", "given": "Hanna", "initials": "H"}, {"family": "Hommel", "given": "Ami", "initials": "A"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "AANA J", "issn": "2162-5239", "issn-l": null, "volume": "91", "issue": "4", "pages": "273-278"}, "abstract": "In spring 2020, a global SARS-Cov-2 pandemic was declared. The number of patients in need of intensive care exceeded the number of available care places at intensive care units (ICUs) and certified registered nurse anesthetists (CRNAs) were relocated to ICUs to support the care during the pandemic. The aim of this study was to illuminate the experiences of the CRNAs regarding relocation to COVID-19 intensive care. An interview study based on qualitative content analysis was conducted. The participants were CRNAs who usually work in the operating unit, however, were relocated to work in the COVID-19 ICU at a university hospital in southern Sweden during the pandemic. Four themes emerge in the results: sense of pride, competence, work environment, and nursing. The results illuminate the CRNAs' experience of relocating from their usual working environment to caring for critically ill patients in a COVID-19 ICU. The CRNAs managed the relocation well, although sometimes it was difficult. The CRNAs showed great loyalty, dedication, competence, and flexibility in their professional capacity. The time they worked in COVID-19 intensive care was a challenging period, but it gave them a well-deserved sense of pride and competence.", "doi": null, "pmid": "37527166", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:01:43.210Z", "modified": "2023-10-05T08:33:29.679Z"}, {"entity": "publication", "iuid": "a6f1f97a78a040648dfc986fcc4278c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6f1f97a78a040648dfc986fcc4278c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6f1f97a78a040648dfc986fcc4278c0"}}, "title": "The impact of hybrid immunity on immune responses after SARS-CoV-2 vaccination in persons with multiple sclerosis treated with disease-modifying therapies.", "authors": [{"family": "Rabenstein", "given": "Monika", "initials": "M"}, {"family": "Thomas", "given": "Olivia G", "initials": "OG"}, {"family": "Carlin", "given": "Giorgia", "initials": "G"}, {"family": "Khademi", "given": "Mohsen", "initials": "M"}, {"family": "H\u00f6gelin", "given": "Klara Asplund", "initials": "KA", "orcid": "0000-0002-3696-355X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e30a564a8ac14f97af8d46d222dff3ab.json"}}, {"family": "Malmestr\u00f6m", "given": "Clas", "initials": "C"}, {"family": "Axelsson", "given": "Markus", "initials": "M"}, {"family": "Brandt", "given": "Anne Frandsen", "initials": "AF"}, {"family": "Gafvelin", "given": "Guro", "initials": "G"}, {"family": "Gr\u00f6nlund", "given": "Hans", "initials": "H"}, {"family": "Kockum", "given": "Ingrid", "initials": "I"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Lycke", "given": "Jan", "initials": "J"}, {"family": "Olsson", "given": "Tomas", "initials": "T"}, {"family": "Hessa", "given": "Tara", "initials": "T"}], "type": "journal article", "published": "2023-07-31", "journal": {"title": "Eur J Neurol", "issn": "1468-1331", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Hybrid immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develops from a combination of natural infection and vaccine-generated immunity. Multiple sclerosis (MS) disease-modifying therapies (DMTs) have the potential to impact humoral and cellular immunity induced by SARS-CoV-2 vaccination and infection. The aims were to compare antibody and T-cell responses after SARS-CoV-2 mRNA vaccination in persons with MS (pwMS) treated with different DMTs and to assess differences between na\u00efvely vaccinated pwMS and pwMS with hybrid immunity vaccinated following a previous SARS-CoV-2 infection.\r\n\r\nAntibody and T-cell responses were determined in pwMS at baseline and 4 and 12 weeks after the second dose of SARS-CoV-2 vaccination in 143 pwMS with or without previous SARS-CoV-2 infection and 40 healthy controls (HCs). The MS cohort comprised natalizumab (n = 22), dimethylfumarate (n = 23), fingolimod (n = 38), cladribine (n = 30), alemtuzumab (n = 17) and teriflunomide (n = 13) treated pwMS. Immunoglobulin G antibody responses to SARS-CoV-2 antigens were measured using a multiplex bead assay and FluoroSpot was used to assess T-cell responses (interferon \u03b3 and interleukin 13).\r\n\r\nHumoral and T-cell responses to vaccination were comparable between na\u00efvely vaccinated HCs and pwMS treated with natalizumab, dimethylfumarate, cladribine, alemtuzumab and teriflunomide, but were suppressed in fingolimod-treated pwMS. Both fingolimod-treated pwMS and HCs vaccinated following a previous SARS-CoV-2 infection had higher antibody levels 4 weeks after vaccination compared to na\u00efvely vaccinated individuals. Antibody and interferon \u03b3 levels 12 weeks after vaccination were positively correlated with time from last treatment course of cladribine.\r\n\r\nThese findings are of relevance for infection risk mitigation and for vaccination strategies amongst pwMS undergoing DMT.", "doi": "10.1111/ene.16015", "pmid": "37522464", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:09:27.597Z", "modified": "2023-10-04T12:53:25.039Z"}, {"entity": "publication", "iuid": "119a8efc353f427ea1abf28986ba5525", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/119a8efc353f427ea1abf28986ba5525.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/119a8efc353f427ea1abf28986ba5525"}}, "title": "Supportive public health leadership for COVID-19 response in Jordan.", "authors": [{"family": "Bellizzi", "given": "Saverio", "initials": "S"}, {"family": "Asghar", "given": "Humayun", "initials": "H"}, {"family": "Bile", "given": "Khalif", "initials": "K"}], "type": "case reports", "published": "2023-07-31", "journal": {"title": "East Mediterr Health J", "issn": "1687-1634", "issn-l": null, "volume": "29", "issue": "7", "pages": "575-579"}, "abstract": "The WHO Regional Office for the Eastern Mediterranean and the United Nations System Staff College (UNSSC) implemented a leadership programme on epidemic and pandemic preparedness and response, specific to the COVID-19 pandemic, during the second half of 2021.\r\n\r\nTo highlight the leadership role played by the WHO Jordan Country Office during the COVID-19 pandemic in collaboration with UNSSC.\r\n\r\nThe WHO Jordan country office successfully leveraged the expertise of UNSSC to implement a leadership training to prepare key stakeholders in Jordan for the response to COVID-19 and similar pandemics or outbreaks. The training curriculum included several modules such as leadership in times of crisis, strategic thinking and planning, emotional resilience, preparedness, adopting a system approach to response, and multisectoral partnership-building for pandemic response. The training helped strengthen the generation of evidence for policymaking and promotion of equitable access to health during the COVID-19 pandemic.\r\n\r\nLeadership capacity strengthening of national counterparts by WHO and partners can help advance efforts at national level to increase the use of evidence for policymaking and response to pandemics and disease outbreaks.", "doi": "10.26719/emhj.23.035", "pmid": "37553746", "labels": {"Category: Public Health": null, "Type: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:08:49.548Z", "modified": "2023-10-06T04:38:03.240Z"}, {"entity": "publication", "iuid": "3610fea119cc4cf5a9d702276b381831", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3610fea119cc4cf5a9d702276b381831.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3610fea119cc4cf5a9d702276b381831"}}, "title": "COVID-19 vaccine safety during pregnancy and breastfeeding in women with autoimmune diseases: results from the COVAD study.", "authors": [{"family": "Andreoli", "given": "Laura", "initials": "L"}, {"family": "Lini", "given": "Daniele", "initials": "D"}, {"family": "Schreiber", "given": "Karen", "initials": "K"}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Naveen", "given": "R", "initials": "R", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Jagtap", "given": "Kshitij", "initials": "K", "orcid": "0000-0003-2729-737X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822b9da98e5d4eb2975ff97fe484933f.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Saha", "given": "Sreoshy", "initials": "S", "orcid": "0000-0001-6745-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00238845dd4833ae51ffb75e2fe144.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Edgar Gracia-Ramos", "given": "Abraham", "initials": "A", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}, {"family": "Patel", "given": "Aarat", "initials": "A"}, {"family": "Pauling", "given": "John D", "initials": "JD", "orcid": "0000-0002-2793-2364", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e37709273d404d17a88c7c850777b99f.json"}}, {"family": "Wincup", "given": "Chris", "initials": "C", "orcid": "0000-0002-8742-8311", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a674f02e7f7f45f58167eb24f81502f3.json"}}, {"family": "Barman", "given": "Bhupen", "initials": "B"}, {"family": "Zamora Tehozol", "given": "Erick Adrian", "initials": "EA", "orcid": "0000-0002-7888-3961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a55c695ac4f4003993a2f511cca7739.json"}}, {"family": "Serrano", "given": "Jorge Rojas", "initials": "JR", "orcid": "0000-0001-6980-7898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/225fd8b396ac40f4a77f1ec229c086b6.json"}}, {"family": "Garc\u00eda-De La Torre", "given": "Ignacio", "initials": "I", "orcid": "0000-0002-9261-678X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/086b85d66fb84b50bd51bbe5a979dfe3.json"}}, {"family": "Colunga-Pedraza", "given": "Iris J", "initials": "IJ", "orcid": "0000-0002-2786-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50e46ef2c7f44b39a1d28fea6a8e621d.json"}}, {"family": "Merayo-Chalico", "given": "Javier", "initials": "J", "orcid": "0000-0002-5870-0523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d74c0ab33cbe4df586e1a1add37d0e65.json"}}, {"family": "Chibuzo", "given": "Okwara Celestine", "initials": "OC"}, {"family": "Katchamart", "given": "Wanruchada", "initials": "W", "orcid": "0000-0002-8952-5967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9439933b38fb49aca8fdbb5038ff603c.json"}}, {"family": "Akarawatcharangura Goo", "given": "Phonpen", "initials": "P"}, {"family": "Shumnalieva", "given": "Russka", "initials": "R", "orcid": "0000-0003-2321-6536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/933232cd7feb48ee81b5971f01f52e23.json"}}, {"family": "Chen", "given": "Yi-Ming", "initials": "Y"}, {"family": "Hoff", "given": "Leonardo Santos", "initials": "LS", "orcid": "0000-0002-2083-4796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1df7af8caf024ca39c57278fdf18c766.json"}}, {"family": "El Kibbi", "given": "Lina", "initials": "L", "orcid": "0000-0003-1710-9996", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11bb4fc524264c6897dec9642a0ef7cd.json"}}, {"family": "Halabi", "given": "Hussein", "initials": "H", "orcid": "0000-0002-5174-8292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb337090a5ab4461a07e8620bee1b4b9.json"}}, {"family": "Vaidya", "given": "Binit", "initials": "B", "orcid": "0000-0002-4840-8924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b2296d53fe14fc7a8415f26e03e1944.json"}}, {"family": "Sazliyana Shaharir", "given": "Syahrul", "initials": "S", "orcid": "0000-0002-9068-8114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1e6310979d44d58b548c61c733412af.json"}}, {"family": "Hasan", "given": "A T M Tanveer", "initials": "ATMT", "orcid": "0000-0002-5332-3319", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ffdb3329292438fac4005923ee79012.json"}}, {"family": "Dey", "given": "Dzifa", "initials": "D"}, {"family": "Guti\u00e9rrez", "given": "Carlos Enrique Toro", "initials": "CET", "orcid": "0000-0002-6084-7049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/980e455c5d114caaaefb6e0b55eaa3b3.json"}}, {"family": "Caballero-Uribe", "given": "Carlo V", "initials": "CV"}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "group", "given": "COVAD study", "initials": "Cs"}, {"family": ",", "given": "", "initials": ""}, {"family": "Chinoy", "given": "Gabriela Arredondo Hector", "initials": "GAH", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}], "type": "journal article", "published": "2023-07-28", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "We investigated COVID-19 vaccine safety in pregnant and breastfeeding women with autoimmune diseases (AID) in the COVID-19 Vaccination in Autoimmune Diseases (COVAD) study.\r\n\r\nDelayed-onset (>7 days) vaccine-related adverse events (AE), disease flares (DF), and AID-related treatment modifications were analyzed upon diagnosis of AID versus healthy controls (HC) and the pregnancy/breastfeeding status at the time of at least one dose of vaccine.\r\n\r\nAmong the 9201 participants to the self-administered online survey, 6787 (73.8%) were women. Forty pregnant and 52 breastfeeding patients with AID were identified, of whom the majority had received at least one dose of COVID-19 vaccine (100% and 96.2%, respectively). AE were reported significantly more frequently in pregnant than in non-pregnant patients (overall AE 45% vs 26%, p= 0.01; minor AE 40% vs 25.9%, p= 0.03; major AE 17.5% vs 4.6%, p< 0.01), but no difference was found in comparison with pregnant HC. No difference was observed between breastfeeding patients and HC with respect to AE. Post-vaccination DF were reported by 17.5% of pregnant and 20% of breastfeeding patients, and by 18.3% of age- and disease-matched non-pregnant and non-breastfeeding patients (n = 262). All pregnant/breastfeeding patients who experienced a DF were managed with glucocorticoids; 28.6% and 20% of them required initiation or change in immunosuppressants, respectively.\r\n\r\nThis study provides reassuring insights into the safety of COVID-19 vaccines administered to women with AID during the gestational and post-partum periods, helping overcome hesitant attitudes, as the benefits for the mother and the fetus by passive immunization appear to outweigh potential risks.", "doi": "10.1093/rheumatology/kead382", "pmid": "37505460", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "7233066"}], "notes": [], "created": "2023-10-04T12:10:03.914Z", "modified": "2023-10-04T13:08:59.955Z"}, {"entity": "publication", "iuid": "02865561b5ed4712a71ebd97c8baa32b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02865561b5ed4712a71ebd97c8baa32b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02865561b5ed4712a71ebd97c8baa32b"}}, "title": "Anxiety, concerns and COVID-19: Cross-country perspectives from families and individuals with neurodevelopmental conditions.", "authors": [{"family": "Sideropoulos", "given": "Vassilis", "initials": "V"}, {"family": "Van Herwegen", "given": "Jo", "initials": "J"}, {"family": "Meuleman", "given": "Ben", "initials": "B"}, {"family": "Alessandri", "given": "Michael", "initials": "M"}, {"family": "Alnemary", "given": "Faisal M", "initials": "FM"}, {"family": "Rad", "given": "Jamal Amani", "initials": "JA"}, {"family": "Lavenex", "given": "Pamela A Banta", "initials": "PAB"}, {"family": "Bolshakov", "given": "Nikita", "initials": "N"}, {"family": "B\u00f6lte", "given": "Sven", "initials": "S"}, {"family": "Buffle", "given": "Paulina", "initials": "P"}, {"family": "Cai", "given": "Ru Y", "initials": "RY"}, {"family": "Campos", "given": "Ruth", "initials": "R"}, {"family": "Chirita-Emandi", "given": "Adela", "initials": "A"}, {"family": "Costa", "given": "Andreia P", "initials": "AP"}, {"family": "Costanzo", "given": "Floriana", "initials": "F"}, {"family": "Des Portes", "given": "Vincent", "initials": "V"}, {"family": "Dukes", "given": "Daniel", "initials": "D"}, {"family": "Faivre", "given": "Laurence", "initials": "L"}, {"family": "Famelart", "given": "Nawelle", "initials": "N"}, {"family": "Fisher", "given": "Marisa H", "initials": "MH"}, {"family": "Gamaiunova", "given": "Liudmilla", "initials": "L"}, {"family": "Giannadou", "given": "Aikaterini", "initials": "A"}, {"family": "Gupta", "given": "Rashmi", "initials": "R"}, {"family": "Hardan", "given": "Antonio Y", "initials": "AY"}, {"family": "Houdayer-Robert", "given": "Fran\u00e7oise", "initials": "F"}, {"family": "Hrncirova", "given": "Lenka", "initials": "L"}, {"family": "Iaochite", "given": "Roberto Tadeu", "initials": "RT"}, {"family": "Jariabkova", "given": "Katarina", "initials": "K"}, {"family": "Klein-Tasman", "given": "Bonita P", "initials": "BP"}, {"family": "Lavenex", "given": "Pierre", "initials": "P"}, {"family": "Malik", "given": "Supriya", "initials": "S"}, {"family": "Mari", "given": "Francesca", "initials": "F"}, {"family": "Martinez-Castilla", "given": "Pastora", "initials": "P"}, {"family": "Menghini", "given": "Deny", "initials": "D"}, {"family": "Nuske", "given": "Heather J", "initials": "HJ"}, {"family": "Palikara", "given": "Olympia", "initials": "O"}, {"family": "Papon", "given": "Anouk", "initials": "A"}, {"family": "Pegg", "given": "Robin S", "initials": "RS"}, {"family": "Pouretemad", "given": "Hamidreza", "initials": "H"}, {"family": "Poustka", "given": "Luise", "initials": "L"}, {"family": "Prosetzky", "given": "Ingolf", "initials": "I"}, {"family": "Renieri", "given": "Alessandra", "initials": "A"}, {"family": "Rhodes", "given": "Sinead M", "initials": "SM"}, {"family": "Riby", "given": "Deborah M", "initials": "DM"}, {"family": "Rossi", "given": "Massimiliano", "initials": "M"}, {"family": "Sadeghi", "given": "Saeid", "initials": "S"}, {"family": "Su", "given": "Xueyen", "initials": "X"}, {"family": "Tai", "given": "Claire", "initials": "C"}, {"family": "Tran", "given": "Michel", "initials": "M"}, {"family": "Tynan", "given": "Fionnuala", "initials": "F"}, {"family": "Uljarevi\u0107", "given": "Mirko", "initials": "M"}, {"family": "Van Hecke", "given": "Amy V", "initials": "AV"}, {"family": "Veiga", "given": "Guida", "initials": "G"}, {"family": "Verloes", "given": "Alain", "initials": "A"}, {"family": "Vicari", "given": "Stefano", "initials": "S"}, {"family": "Werneck-Rohrer", "given": "Sonja G", "initials": "SG"}, {"family": "Zander", "given": "Eric", "initials": "E"}, {"family": "Samson", "given": "Andrea C", "initials": "AC"}], "type": "journal article", "published": "2023-07-28", "journal": {"title": "J Glob Health", "issn": "2047-2986", "issn-l": "2047-2978", "volume": "13", "issue": null, "pages": "04081"}, "abstract": "The COVID-19 pandemic had a major impact on the mental health and well-being of children with neurodevelopmental conditions (NDCs) and of their families worldwide. However, there is insufficient evidence to understand how different factors (e.g., individual, family, country, children) have impacted on anxiety levels of families and their children with NDCs developed over time.\r\n\r\nWe used data from a global survey assessing the experience of 8043 families and their children with NDCs (mean of age (m) = 13.18 years, 37% female) and their typically developing siblings (m = 12.9 years, 45% female) in combination with data from the European Centre for Disease Prevention and Control, the University of Oxford, and the Central Intelligence Agency (CIA) World Factbook, to create a multilevel data set. Using stepwise multilevel modelling, we generated child-, family- and country-related factors that may have contributed to the anxiety levels of children with NDCs, their siblings if they had any, and their parents. All data were reported by parents.\r\n\r\nOur results suggest that parental anxiety was best explained by family-related factors such as concerns about COVID-19 and illness. Children's anxiety was best explained by child-related factors such as children's concerns about loss of routine, family conflict, and safety in general, as well as concerns about COVID-19. In addition, anxiety levels were linked to the presence of pre-existing anxiety conditions for both children with NDCs and their parents.\r\n\r\nThe present study shows that across the globe there was a raise in anxiety levels for both parents and their children with NDCs because of COVID-19 and that country-level factors had little or no impact on explaining differences in this increase, once family and child factors were considered. Our findings also highlight that certain groups of children with NDCs were at higher risk for anxiety than others and had specific concerns. Together, these results show that anxiety of families and their children with NDCs during the COVID-19 pandemic were predicted by very specific concerns and worries which inform the development of future toolkits and policy. Future studies should investigate how country factors can play a protective role during future crises.", "doi": "10.7189/jogh.13.04081", "pmid": "37497751", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10373111"}], "notes": [], "created": "2023-10-04T12:10:01.287Z", "modified": "2023-10-04T13:08:11.013Z"}, {"entity": "publication", "iuid": "959d789ffbd645a49354b747833a4cba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/959d789ffbd645a49354b747833a4cba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/959d789ffbd645a49354b747833a4cba"}}, "title": "The Impact of the COVID-19 Pandemic on Cutaneous Drug Eruptions in a Swedish Health Region without Lockdown.", "authors": [{"family": "Pissa", "given": "Maria", "initials": "M"}, {"family": "Jerkovic Gulin", "given": "Sandra", "initials": "S"}], "type": "journal article", "published": "2023-07-27", "journal": {"title": "Microorganisms", "issn": "2076-2607", "issn-l": "2076-2607", "volume": "11", "issue": "8", "pages": null}, "abstract": "The incidence of severe cutaneous drug eruptions during the COVID-19 period in Sweden has not been studied previously. Our aim was to compare the incidence of these skin reactions in a Swedish health region during the COVID-19 pandemic period with that of the year after: we conducted a retrospective, observational cohort study using data from a national registry of patients diagnosed with cutaneous drug eruptions during the pandemic in Sweden. We included the number of patients diagnosed with severe cutaneous drug eruptions at the Department of Dermatology in the Jonkoping health region during the COVID-19 pandemic (1 April 2020 to 31 March 2021) and the reference period (1 April 2021 to 31 March 2022). We examined the monthly occurrences of cutaneous drug eruptions in three dermatology clinics within the Jonkoping health region. The frequency of these eruptions was determined for two distinct time periods: during the pandemic and post-pandemic. The study included 102 patients with cutaneous drug eruptions: 29 patients were diagnosed during the COVID-19 pandemic period and 73 were diagnosed during the reference period. The difference in the number of cutaneous drug eruptions cases (p-value = 0.0001, 95% CI 1.4995-3.5500, OR 2.3072) during the pandemic period compared to the post-pandemic period was significant. To our knowledge, the impact of the pandemic on cutaneous drug eruptions has not been investigated in EU countries. The increasing and differentiation of the number of diagnosed cutaneous drug eruptions cases after the pandemic could be explained by the removal of COVID-19 restrictions and the more frequent health-seeking behavior during the post-pandemic period.", "doi": "10.3390/microorganisms11081913", "pmid": "37630473", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10459394"}, {"db": "pii", "key": "microorganisms11081913"}], "notes": [], "created": "2023-10-05T08:08:42.023Z", "modified": "2023-10-06T04:31:38.188Z"}, {"entity": "publication", "iuid": "58384bfd215648a29216bdea3bb43ada", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/58384bfd215648a29216bdea3bb43ada.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/58384bfd215648a29216bdea3bb43ada"}}, "title": "Immune response to SARS-CoV-2 mRNA vaccination in multiple sclerosis patients after rituximab treatment interruption.", "authors": [{"family": "Gr\u00f6ning", "given": "Remigius", "initials": "R"}, {"family": "Dernstedt", "given": "Andy", "initials": "A"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Sundstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}], "type": "journal article", "published": "2023-07-27", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "1219560"}, "abstract": "Peripheral B cell depletion via anti-CD20 treatment is a highly effective disease-modifying treatment for reducing new relapses in multiple sclerosis (MS) patients. A drawback of rituximab (RTX) and other anti-CD20 antibodies is a poor immune response to vaccination. While this can be mitigated by treatment interruption of at least six months prior to vaccination, the timing to resume treatment while maintaining subsequent vaccine responses remains undetermined. Here, we characterized SARS-CoV-2 S-directed antibody and B cell responses throughout three BNT162b2 mRNA vaccine doses in RTX-treated MS patients, with the first two doses given during treatment interruption. We examined B-cell mediated immune responses in blood samples from patients with RTX-treated MS throughout three BNT162b2 vaccine doses, compared to an age- and sex-matched healthy control group. The first vaccine dose was given 1.3 years (median) after the last RTX infusion, the second dose one month after the first, and the third dose four weeks after treatment re-initiation. We analyzed SARS-CoV-2 S-directed antibody levels using enzyme-linked immunosorbent assay (ELISA), and the neutralization capacity of patient serum against SARS-CoV-2 S-pseudotyped lentivirus using luciferase reporter assay. In addition, we assessed switched memory (CD19+CD20+CD27+IgD-), unswitched memory (CD19+CD20+CD27+IgD+), na\u00efve (CD19+CD20+CD27-IgD+), and double negative (DN, CD19+CD20+CD27-IgD-) B cell frequencies, as well as their SARS-CoV-2 S-specific (CoV+) and Decay Accelerating Factor-negative (DAF-) subpopulations, using flow cytometry. After two vaccine doses, S-binding antibody levels and neutralization capacity in SARS-CoV-2-na\u00efve MS patients were comparable to vaccinated healthy controls, albeit with greater variation. Higher antibody response levels and CoV+-DN B cell frequencies after the second vaccine dose were predictive of a boost effect after the third dose, even after re-initiation of rituximab treatment. MS patients also exhibited lower frequencies of DAF- memory B cells, a suggested proxy for germinal centre activity, than control individuals. S-binding antibody levels in RTX-treated MS patients after two vaccine doses could help determine which individuals would need to move up their next vaccine booster dose or postpone their next RTX infusion. Our findings also offer first indications on the potential importance of antigenic stimulation of DN B cells and long-term impairment of germinal centre activity in rituximab-treated MS patients.", "doi": "10.3389/fimmu.2023.1219560", "pmid": "37575257", "labels": {"Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10413123"}], "notes": [], "created": "2023-10-05T08:26:16.770Z", "modified": "2023-10-06T04:53:07.553Z"}, {"entity": "publication", "iuid": "a3ff29086df3421ca10205e0fd0dc8c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3ff29086df3421ca10205e0fd0dc8c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3ff29086df3421ca10205e0fd0dc8c9"}}, "title": "Policies on children and schools during the SARS-CoV-2 pandemic in Western Europe.", "authors": [{"family": "Soriano-Arandes", "given": "Antoni", "initials": "A"}, {"family": "Brett", "given": "Ana", "initials": "A"}, {"family": "Buonsenso", "given": "Danilo", "initials": "D"}, {"family": "Emilsson", "given": "Louise", "initials": "L"}, {"family": "de la Fuente Garcia", "given": "Isabel", "initials": "I"}, {"family": "Gkentzi", "given": "Despoina", "initials": "D"}, {"family": "Helve", "given": "Otto", "initials": "O"}, {"family": "Kepp", "given": "Kasper P", "initials": "KP"}, {"family": "Mossberg", "given": "Maria", "initials": "M"}, {"family": "Muka", "given": "Taulant", "initials": "T"}, {"family": "Munro", "given": "Alasdair", "initials": "A"}, {"family": "Papan", "given": "Cihan", "initials": "C"}, {"family": "Perramon-Malavez", "given": "Aida", "initials": "A"}, {"family": "Schaltz-Buchholzer", "given": "Frederik", "initials": "F"}, {"family": "Smeesters", "given": "Pierre R", "initials": "PR"}, {"family": "Zimmermann", "given": "Petra", "initials": "P"}], "type": "journal article", "published": "2023-07-25", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "1175444"}, "abstract": "During the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), mitigation policies for children have been a topic of considerable uncertainty and debate. Although some children have co-morbidities which increase their risk for severe coronavirus disease (COVID-19), and complications such as multisystem inflammatory syndrome and long COVID, most children only get mild COVID-19. On the other hand, consistent evidence shows that mass mitigation measures had enormous adverse impacts on children. A central question can thus be posed: What amount of mitigation should children bear, in response to a disease that is disproportionally affecting older people? In this review, we analyze the distinct child versus adult epidemiology, policies, mitigation trade-offs and outcomes in children in Western Europe. The highly heterogenous European policies applied to children compared to adults did not lead to significant measurable differences in outcomes. Remarkably, the relative epidemiological importance of transmission from school-age children to other age groups remains uncertain, with current evidence suggesting that schools often follow, rather than lead, community transmission. Important learning points for future pandemics are summarized.", "doi": "10.3389/fpubh.2023.1175444", "pmid": "37564427", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10411527"}], "notes": [], "created": "2023-10-05T08:02:38.935Z", "modified": "2023-10-05T08:48:36.368Z"}, {"entity": "publication", "iuid": "5197070c0aaa4a3fa1e29395a456374d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5197070c0aaa4a3fa1e29395a456374d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5197070c0aaa4a3fa1e29395a456374d"}}, "title": "Comparative effectiveness of bivalent BA.4-5 and BA.1 mRNA booster vaccines among adults aged \u226550 years in Nordic countries: nationwide cohort study.", "authors": [{"family": "Andersson", "given": "Niklas Worm", "initials": "NW", "orcid": "0000-0001-7622-6303", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e4000bddcc34ce5987e9ccccc76a858.json"}}, {"family": "Thiesson", "given": "Emilia Myrup", "initials": "EM"}, {"family": "Baum", "given": "Ulrike", "initials": "U"}, {"family": "Pihlstr\u00f6m", "given": "Nicklas", "initials": "N"}, {"family": "Starrfelt", "given": "Jostein", "initials": "J"}, {"family": "Faksov\u00e1", "given": "Krist\u00fdna", "initials": "K"}, {"family": "Poukka", "given": "Eero", "initials": "E"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}, {"family": "Ljung", "given": "Rickard", "initials": "R"}, {"family": "Hviid", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2023-07-25", "journal": {"title": "BMJ", "issn": "1756-1833", "issn-l": null, "volume": "382", "issue": null, "pages": "e075286"}, "abstract": "To estimate the effectiveness of the bivalent mRNA booster vaccines containing the original SARS-CoV-2 and omicron BA.4-5 or BA.1 subvariants as the fourth dose against severe covid-19.\r\n\r\nNationwide cohort analyses, using target trial emulation.\r\n\r\nDenmark, Finland, Norway, and Sweden, from 1 July 2022 to 10 April 2023.\r\n\r\nPeople aged \u226550 years who had received at least three doses of covid-19 vaccine (that is, a primary course and a first booster).\r\n\r\nThe Kaplan-Meier estimator was used to compare the risk of hospital admission and death related to covid-19 in people who received a bivalent Comirnaty (Pfizer-BioNTech) or Spikevax (Moderna) BA.4-5 or BA.1 mRNA booster vaccine as a fourth dose (second booster) with three dose (first booster) vaccinated people and between four dose vaccinated people.\r\n\r\nA total of 1 634 199 people receiving bivalent BA.4-5 fourth dose booster and 1 042 124 receiving bivalent BA.1 fourth dose booster across the four Nordic countries were included. Receipt of a bivalent BA.4-5 booster as a fourth dose was associated with a comparative vaccine effectiveness against admission to hospital with covid-19 of 67.8% (95% confidence interval 63.1% to 72.5%) and a risk difference of -91.9 (95% confidence interval -152.4 to -31.4) per 100 000 people at three months of follow-up compared with having received three doses of vaccine (289 v 893 events). The corresponding comparative vaccine effectiveness and risk difference for bivalent BA.1 boosters (332 v 977 events) were 65.8% (59.1% to 72.4%) and -112.9 (-179.6 to -46.2) per 100 000, respectively. Comparative vaccine effectiveness and risk difference against covid-19 related death were 69.8% (52.8% to 86.8%) and -34.1 (-40.1 to -28.2) per 100 000 for bivalent BA.4-5 booster (93 v 325 events) and 70.0% (50.3% to 89.7%) and -38.7 (-65.4 to -12.0) per 100 000 for BA.1 booster (86 v 286) as a fourth dose. Comparing bivalent BA.4-5 and BA.1 boosters as a fourth dose directly resulted in a three month comparative vaccine effectiveness and corresponding risk difference of -14.9% (-62.3% to 32.4%) and 10.0 (-14.4 to 34.4) per 100 000 people for admission to hospital with covid-19 (802 v 932 unweighted events) and -40.7% (-123.4% to 42.1%) and 8.1 (-3.3 to 19.4) per 100 000 for covid-19 related death (229 v 243 unweighted events). The comparative vaccine effectiveness did not differ across sex and age (<\/\u226570 years) and seemed to be sustained up to six months from the day of vaccination with modest waning.\r\n\r\nVaccination with bivalent BA.4-5 or BA.1 mRNA booster vaccines as a fourth dose was associated with reduced rates of covid-19 related hospital admission and death among adults aged \u226550 years. The protection afforded by the bivalent BA.4-5 and BA.1 boosters did not differ significantly when directly compared, and any potential difference would most likely be very small in absolute numbers.", "doi": "10.1136/bmj-2022-075286", "pmid": "37491022", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10364194"}], "notes": [], "created": "2023-10-04T12:08:15.579Z", "modified": "2023-10-04T12:31:14.841Z"}, {"entity": "publication", "iuid": "0b66e9f896bc494991a0bbf34ef5df9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b66e9f896bc494991a0bbf34ef5df9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b66e9f896bc494991a0bbf34ef5df9c"}}, "title": "Comparative effectiveness of heterologous third dose vaccine schedules against severe covid-19 during omicron predominance in Nordic countries: population based cohort analyses.", "authors": [{"family": "Andersson", "given": "Niklas Worm", "initials": "NW", "orcid": "0000-0001-7622-6303", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e4000bddcc34ce5987e9ccccc76a858.json"}}, {"family": "Thiesson", "given": "Emilia Myrup", "initials": "EM"}, {"family": "Baum", "given": "Ulrike", "initials": "U"}, {"family": "Pihlstr\u00f6m", "given": "Nicklas", "initials": "N"}, {"family": "Starrfelt", "given": "Jostein", "initials": "J"}, {"family": "Faksov\u00e1", "given": "Krist\u00fdna", "initials": "K"}, {"family": "Poukka", "given": "Eero", "initials": "E"}, {"family": "Lund", "given": "Lars Christian", "initials": "LC"}, {"family": "Hansen", "given": "Christian Holm", "initials": "CH"}, {"family": "Aakj\u00e6r", "given": "Mia", "initials": "M"}, {"family": "Kj\u00e6r", "given": "Jesper", "initials": "J"}, {"family": "Cohet", "given": "Catherine", "initials": "C"}, {"family": "Goossens", "given": "Mathijs", "initials": "M"}, {"family": "Andersen", "given": "Morten", "initials": "M"}, {"family": "Hallas", "given": "Jesper", "initials": "J"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}, {"family": "Ljung", "given": "Rickard", "initials": "R"}, {"family": "Hviid", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2023-07-24", "journal": {"title": "BMJ", "issn": "1756-1833", "issn-l": null, "volume": "382", "issue": null, "pages": "e074325"}, "abstract": "To investigate the comparative vaccine effectiveness of heterologous booster schedules (ie, three vaccine doses) compared with primary schedules (two vaccine doses) and with homologous mRNA vaccine booster schedules (three vaccine doses) during a period of omicron predominance.\r\n\r\nPopulation based cohort analyses.\r\n\r\nDenmark, Finland, Norway, and Sweden, 27 December 2020 to 31 December 2022.\r\n\r\nAll adults aged \u226518 years who had received at least a primary vaccination schedule of AZD1222 (Oxford-AstraZeneca) or monovalent SARS-CoV-2 wild type (ancestral) strain based mRNA vaccines BNT162b2 (Pfizer-BioNTech) or mRNA-1273 (Moderna), in any combination.\r\n\r\nThe main outcome measure was country combined risks of covid-19 related hospital admission and death with covid-19 and additional outcomes of covid-19 related admission to an intensive care unit and SARS-CoV-2 infection. During a period of omicron predominance, these outcomes were compared in those who received a heterologous booster versus primary schedule (matched analyses) and versus those who received a homologous mRNA vaccine booster (weighted analyses). Follow-up was for 75 days from day 14 after the booster dose; comparative vaccine effectiveness was calculated as 1-risk ratio.\r\n\r\nAcross the four Nordic countries, 1 086 418 participants had received a heterologous booster schedule of AZD1222+BNT162b2 or mRNA-1273 and 2 505 093 had received a heterologous booster schedule of BNT162b2+mRNA-1273. Compared with the primary schedule only (two doses), the vaccine effectiveness of heterologous booster schedules comprising AZD1222+BNT162b2 or mRNA-1273 and BNT162b2+mRNA-1273 was 82.7% (95% confidence interval 77.1% to 88.2%) and 81.5% (78.9% to 84.2%) for covid-19 related hospital admission and 95.9% (91.6% to 100.0%) and 87.5% (82.5% to 92.6%) for death with covid-19, respectively. Homologous mRNA booster schedules were similarly associated with increased protection against covid-19 related hospital admission (\u226576.5%) and death with covid-19 (\u226584.1%) compared with previous primary course vaccination only. When a heterologous booster schedule was compared with the homologous booster schedule, vaccine effectiveness was 27.2% (3.7% to 50.6%) for AZD1222+BNT162b2 or mRNA-1273 and 23.3% (15.8% to 30.8%) for BNT162b2+mRNA-1273 schedules against covid-19 related hospital admission and 21.7% (-8.3% to 51.7%) and 18.4% (-15.7% to 52.5%) against death with covid-19, respectively.\r\n\r\nHeterologous booster schedules are associated with increased protection against severe, omicron related covid-19 outcomes compared with primary course schedules and homologous booster schedules.", "doi": "10.1136/bmj-2022-074325", "pmid": "37487623", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10360027"}], "notes": [], "created": "2023-10-04T12:07:43.563Z", "modified": "2023-10-04T12:23:39.030Z"}, {"entity": "publication", "iuid": "979c9b04b372456284e6e053caac01f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/979c9b04b372456284e6e053caac01f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/979c9b04b372456284e6e053caac01f4"}}, "title": "COVID-19-Induced Acute Respiratory Distress Syndrome Treated with Hyperbaric Oxygen: Interim Safety Report from a Randomized Clinical Trial (COVID-19-HBO).", "authors": [{"family": "Kjellberg", "given": "Anders", "initials": "A", "orcid": "0000-0002-4819-1024", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81941232265d46679c08c40c068e91c4.json"}}, {"family": "Douglas", "given": "Johan", "initials": "J"}, {"family": "Hassler", "given": "Adrian", "initials": "A"}, {"family": "Al-Ezerjawi", "given": "Sarah", "initials": "S"}, {"family": "Bostr\u00f6m", "given": "Emil", "initials": "E"}, {"family": "Abdel-Halim", "given": "Lina", "initials": "L"}, {"family": "Liwenborg", "given": "Lovisa", "initials": "L"}, {"family": "Hetting", "given": "Eric", "initials": "E"}, {"family": "Jonasdottir Nj\u00e5stad", "given": "Anna Dora", "initials": "AD"}, {"family": "Kowalski", "given": "Jan", "initials": "J"}, {"family": "Catrina", "given": "Sergiu-Bogdan", "initials": "S"}, {"family": "Rodriguez-Wallberg", "given": "Kenny A", "initials": "KA", "orcid": "0000-0003-4378-6181", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d45aa8a66f64858b4f9be050046e8a2.json"}}, {"family": "Lindholm", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2023-07-24", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "12", "issue": "14", "pages": null}, "abstract": "A few prospective trials and case series have suggested that hyperbaric oxygen therapy (HBOT) may be efficacious for the treatment of severe COVID-19, but safety is a concern for critically ill patients. We present an interim analysis of the safety of HBOT via a randomized controlled trial (COVID-19-HBO).\r\n\r\nA randomized controlled, open-label, clinical trial was conducted in compliance with good clinical practice to explore the safety and efficacy of HBOT for severe COVID-19 in critically ill patients with moderate acute respiratory distress syndrome (ARDS). Between 3 June 2020, and 17 May 2021, 31 patients with severe COVID-19 and moderate-to-severe ARDS, a ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FiO2) < 26.7 kPa (200 mmHg), and at least two defined risk factors for intensive care unit (ICU) admission and/or mortality were enrolled in the trial and randomized 1:1 to best practice, or HBOT in addition to best practice. The subjects allocated to HBOT received a maximum of five treatments at 2.4 atmospheres absolute (ATA) for 80 min over seven days. The subjects were followed up for 30 days. The safety endpoints were analyzed.\r\n\r\nAdverse events (AEs) were common. Hypoxia was the most common adverse event reported. There was no statistically significant difference between the groups. Numerically, serious adverse events (SAEs) and barotrauma were more frequent in the control group, and the differences between groups were in favor of the HBOT in PaO2/FiO2 (PFI) and the national early warning score (NEWS); statistically, however, the differences were not significant at day 7, and no difference was observed for the total oxygen burden and cumulative pulmonary oxygen toxicity dose (CPTD).\r\n\r\nHBOT appears to be safe as an intervention for critically ill patients with moderate-to-severe ARDS induced by COVID-19.\r\n\r\nNCT04327505 (31 March 2020) and EudraCT 2020-001349-37 (24 April 2020).", "doi": "10.3390/jcm12144850", "pmid": "37510965", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10381696"}, {"db": "pii", "key": "jcm12144850"}, {"db": "ClinicalTrials.gov", "key": "NCT04327505"}], "notes": [], "created": "2023-10-04T12:09:00.800Z", "modified": "2023-10-04T12:46:57.143Z"}, {"entity": "publication", "iuid": "3a6da6658c9b475c8daae7db7eee70c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a6da6658c9b475c8daae7db7eee70c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a6da6658c9b475c8daae7db7eee70c9"}}, "title": "The European experience with testing and surveillance during the first phase of the COVID-19 pandemic.", "authors": [{"family": "Stoto", "given": "Michael A", "initials": "MA", "orcid": "0000-0001-8293-471X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0312d97d6e2d4101b691bae6dbec98cb.json"}}, {"family": "Reno", "given": "Chiara", "initials": "C"}, {"family": "Tsolova", "given": "Svetla", "initials": "S"}, {"family": "Fantini", "given": "Maria Pia", "initials": "MP"}], "type": "journal article", "published": "2023-07-21", "journal": {"title": "Global Health", "issn": "1744-8603", "issn-l": "1744-8603", "volume": "19", "issue": "1", "pages": "51"}, "abstract": "COVID-19 pandemic provides a unique opportunity to learn the challenges encountered by public health emergency preparedness systems, both in terms of problems encountered and adaptations during and after the first wave, as well as successful responses to them.\r\n\r\nThis work draws on published literature, interviews with countries and institutional documents as part of a European Centre for Disease Prevention and Control project that aims to identify the implications for preparedness measurement derived from COVID-19 pandemic experience in order to advance future preparedness efforts in European Union member states. The analysis focused on testing and surveillance themes and five countries were considered, namely Italy, Germany, Finland, Spain and Croatia. Our analysis shown that a country's ability to conduct testing at scale was critical, especially early in the pandemic, and the inability to scale up testing operations created critical issues for public health operations such as contact tracing. Countries were required to develop new strategies, approaches, and policies under pressure and to review and revise them as the pandemic evolved, also considering that public health systems operate at the national, regional, and local level with respect to testing, contact tracing, and surveillance, and involve both government agencies as well as private organizations. Therefore, communication among multiple public and private entities at all levels and coordination of the testing and surveillance activities was critical.\r\n\r\nWith regard to testing and surveillance, three capabilities that were essential to the COVID-19 response in the first phase, and presumably in other public health emergencies: the ability to scale-up testing, contact tracing, surveillance efforts; flexibility to develop new strategies, approaches, and policies under pressure and to review and revise them as the pandemic evolved; and the ability to coordinate and communicate in complex public health systems that operate at the national, regional, and local level with respect and involve multiple government agencies as well as private organizations.", "doi": "10.1186/s12992-023-00950-9", "pmid": "37480125", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10362750"}, {"db": "pii", "key": "10.1186/s12992-023-00950-9"}], "notes": [], "created": "2023-10-04T12:09:51.345Z", "modified": "2023-10-04T13:03:47.580Z"}, {"entity": "publication", "iuid": "160193d3938347ad86b525744a2c8d29", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/160193d3938347ad86b525744a2c8d29.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/160193d3938347ad86b525744a2c8d29"}}, "title": "The Swedish COVID-19 approach: a scientific dialogue on mitigation policies.", "authors": [{"family": "Bj\u00f6rkman", "given": "Anders", "initials": "A"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Gullberg", "given": "Martin", "initials": "M"}, {"family": "Ludvigsson", "given": "Johnny", "initials": "J"}], "type": "journal article", "published": "2023-07-20", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "1206732"}, "abstract": "During the COVID-19 pandemic, Sweden was among the few countries that did not enforce strict lockdown measures but instead relied more on voluntary and sustainable mitigation recommendations. While supported by the majority of Swedes, this approach faced rapid and continuous criticism. Unfortunately, the respectful debate centered around scientific evidence often gave way to mudslinging. However, the available data on excess all-cause mortality rates indicate that Sweden experienced fewer deaths per population unit during the pandemic (2020-2022) than most high-income countries and was comparable to neighboring Nordic countries through the pandemic. An open, objective scientific dialogue is essential for learning and preparing for future outbreaks.", "doi": "10.3389/fpubh.2023.1206732", "pmid": "37546333", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10399217"}], "notes": [], "created": "2023-10-05T08:26:19.099Z", "modified": "2023-10-06T04:54:29.036Z"}, {"entity": "publication", "iuid": "17188b1b0b85452b82f931ef6a1c0098", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/17188b1b0b85452b82f931ef6a1c0098.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/17188b1b0b85452b82f931ef6a1c0098"}}, "title": "Making things work-In spite of a pandemic small scale enterprise managers' approach to business changes and health issues.", "authors": [{"family": "Landstad", "given": "Bodil J", "initials": "BJ", "orcid": "0000-0001-6558-3129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bdb9f75451d4f2b8c87a8f8a837a09d.json"}}, {"family": "Hedlund", "given": "Marianne", "initials": "M", "orcid": "0000-0002-1789-2477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d8e2939573845109d470f05b8314cee.json"}}, {"family": "Tjulin", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Nordenmark", "given": "Mikael", "initials": "M"}, {"family": "Vinberg", "given": "Stig", "initials": "S"}], "type": "journal article", "published": "2023-07-20", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "7", "pages": "e0288837"}, "abstract": "Covid-19 is one of the worst crises in modern working life with a direct negative impact on many enterprises and organizations. The aim of this study is to explore what managers in Small Scale Enterprises (SSEs) changed in their business during the Covid-19 pandemic, particularly addressing health issues.\r\n\r\nA longitudinal qualitative research methodology was used, interviewing 16 managers of SSEs in the Norwegian and Swedish manufacturing and service sector both before (round 1) and during the pandemic (round 2). In this approach, time is designed into the research process, making change a key focus for analysis.\r\n\r\nThe analysis resulted in two main themes, resilience and demanding occupational health and safety conditions, and five sub-themes. Results show how managers in SSEs changed their business during the Covid-19 pandemic and the impact of these changes. Although, the enterprises were heavily affected in the beginning of the pandemic, several managers found new solutions for their businesses to maintain and reach new customers. They applied a socially responsible management which addressed different health issues.\r\n\r\nCrises like the Covid-19 pandemic will have future impact on SSEs making it important to understand how managers in such enterprises address business and health issues. This knowledge may have practical implications for supporting managers in SSEs in how to perform a socially responsible management and maintain occupational health and safety measures. The managerial implications from this research are that they need to be flexible, reorientable and, at the same time, be loyal to the core business. This study shows the importance of doing longitudinal studies about business and health issues among mangers in SSEs.", "doi": "10.1371/journal.pone.0288837", "pmid": "37471417", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10358884"}, {"db": "pii", "key": "PONE-D-22-33735"}], "notes": [], "created": "2023-10-04T12:08:53.047Z", "modified": "2023-10-04T12:44:21.257Z"}, {"entity": "publication", "iuid": "8e0ff59d5c834afea39bb6f6652728e9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e0ff59d5c834afea39bb6f6652728e9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e0ff59d5c834afea39bb6f6652728e9"}}, "title": "Assessing the Knowledge, Attitudes, and Vaccination Practices Towards COVID-19 Vaccination Among Mainland Chinese Nursing Students and Interns: A Multicenter Cross-Sectional Study.", "authors": [{"family": "Qin", "given": "Zhuzhu", "initials": "Z"}, {"family": "Ye", "given": "Xinxin", "initials": "X"}, {"family": "Liu", "given": "Huanju", "initials": "H", "orcid": "0000-0002-3370-4296", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51415df31c7340ebb01f7537f1a86fce.json"}}, {"family": "Tao", "given": "Yining", "initials": "Y"}, {"family": "Zheng", "given": "Xutong", "initials": "X"}, {"family": "Zhong", "given": "Yanxia", "initials": "Y"}, {"family": "Chen", "given": "Danfeng", "initials": "D"}, {"family": "Ye", "given": "Wan", "initials": "W"}, {"family": "Zhan", "given": "Chenju", "initials": "C"}], "type": "journal article", "published": "2023-07-20", "journal": {"title": "Infect Drug Resist", "issn": "1178-6973", "issn-l": null, "volume": "16", "issue": null, "pages": "4717-4728"}, "abstract": "This study investigated factors influencing the knowledge, attitudes, practice profiles, and vaccination intentions among Chinese nursing students and nursing interns toward the coronavirus disease (COVID-19) vaccination.\r\n\r\nThe multicenter cross-sectional study was based on a self-reported questionnaire collecting information among nursing students and nursing interns from three major geographic regions of China, and the sample was selected by consecutive sampling. The questionnaire was developed by knowledge, attitudes, and practice (KAP) theory. Univariate and multivariate logistic regression were used for statistical analysis.\r\n\r\nA total of 3180 nursing students and interns (effective rate: 99.8%) from six Chinese provinces were polled. The vaccine hesitation rate was 9.65% (307/3180), 2230 participants (70.1%) had gotten at least one dose of the vaccine, and 643 participants (67.7%) had indicated a readiness to be vaccinated. The results showed that older age, higher academic background, perfect vaccine management, others' recommendations, influenza vaccination history, epidemic under control, knowledge of vaccines or intervals, and vaccine knowledge training were associated with higher vaccination rates. Conversely, vaccine hesitancy was caused by a perceived lack of physical need, uncertainty about vaccination requirements, and fear of vaccination.\r\n\r\nThis study provided population-based estimates of COVID-19 vaccine uptake intention among mainland Chinese nursing students and interns. Factors such as age, education, vaccine knowledge, and attitudes influence COVID-19 vaccine behaviour. Relevant authorities should understand the barriers to COVID-19 vaccination from knowledge, attitude and practice, which is significant for formulating effective response strategies in future global public health crises.", "doi": "10.2147/IDR.S415799", "pmid": "37496694", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10366673"}, {"db": "pii", "key": "415799"}], "notes": [], "created": "2023-10-04T12:09:53.826Z", "modified": "2023-10-04T13:04:36.946Z"}, {"entity": "publication", "iuid": "cf40e0b6004f481a992235ec3e50a034", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cf40e0b6004f481a992235ec3e50a034.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cf40e0b6004f481a992235ec3e50a034"}}, "title": "Understanding concerns after severe COVID-19: A self-imposed lockdown guarded by anxiety?", "authors": [{"family": "T\u00f6rnbom", "given": "Karin", "initials": "K", "orcid": "0000-0002-7593-2051", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64aa524f1b9d4b6a8e14312c6b298546.json"}}, {"family": "Larsson", "given": "Alexandra", "initials": "A"}, {"family": "Sunnerhagen", "given": "Katharina S", "initials": "KS"}, {"family": "Palstam", "given": "Annie", "initials": "A"}, {"family": "Persson", "given": "Hanna C", "initials": "HC"}], "type": "journal article", "published": "2023-07-19", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "7", "pages": "e0287981"}, "abstract": "Many people are struggling to get back to their lives after severe COVID-19. To facilitate their reintegration into everyday life, we need to understand how the process is experienced. We aimed to gain deeper knowledge about this process by interviewing persons one year after hospitalisation due to COVID-19.\r\n\r\nThe study is based on a qualitative design, with eleven in-depth interviews conducted one year after discharge for COVID-19. Participants were recruited to form a heterogeneous sample with respect to age, gender and socioeconomic background. All interviews were analysed utilising inductive thematic analysis.\r\n\r\nFrom the participants' narratives four themes were identified: 'Concerns and worries in everyday life', 'Supportive and concerned relatives', 'A new way of life-sorrows and advantages' and 'Seize the day-a greater awareness of one\u00b4s mortality'. Participants described how they tried to create a functioning everyday life. They were generally afraid of getting COVID-19 again and concerned about future life, where their lack of energy played a major role. Narratives were diverse regarding to what extent the struggle to cope was experienced as emotionally challenging or not.\r\n\r\nParticipants described an unpredictable recovery after COVID-19, characterised by ups and downs, which created worries concerning their future. In some cases, the worry of getting COVID-19 again was strong enough to keep participants in their homes, as a self-imposed lockdown guarded by anxiety. However, the narratives also revealed gratitude towards being alive and having coped so well. This led to a more positive outlook on life with a greater focus on intrinsic values, close social relations and the deeper meaning of life.", "doi": "10.1371/journal.pone.0287981", "pmid": "37467220", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10355428"}, {"db": "pii", "key": "PONE-D-22-34035"}], "notes": [], "created": "2023-10-04T12:08:26.208Z", "modified": "2023-10-04T12:35:13.421Z"}, {"entity": "publication", "iuid": "84926b3365624d769652f76338c3b874", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84926b3365624d769652f76338c3b874.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84926b3365624d769652f76338c3b874"}}, "title": "Totality of evidence of the effectiveness of repurposed therapies for COVID-19: Can we use real-world studies alongside randomized controlled trials?", "authors": [{"family": "Mandema", "given": "Jaap", "initials": "J"}, {"family": "Montgomery", "given": "Hugh", "initials": "H"}, {"family": "Dron", "given": "Louis", "initials": "L"}, {"family": "Fu", "given": "Shuai", "initials": "S", "orcid": "0000-0003-1889-3030", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f6c25a0a15240dbace467b7b5b2869e.json"}}, {"family": "Russek-Cohen", "given": "Estelle", "initials": "E"}, {"family": "Bromley", "given": "Christina", "initials": "C"}, {"family": "Mouksassi", "given": "Samer", "initials": "S", "orcid": "0000-0002-7152-6654", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f160080128543c0bb3ff50d0c56f091.json"}}, {"family": "Lalonde", "given": "Amy", "initials": "A"}, {"family": "Springford", "given": "Aaron", "initials": "A", "orcid": "0000-0001-7179-9049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa09157725754184ae5d22671b82af21.json"}}, {"family": "Tsai", "given": "Larry", "initials": "L", "orcid": "0000-0002-4787-2100", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/866e5b6ff6b54c2a8ac0d8b7170aef13.json"}}, {"family": "Ambery", "given": "Phil", "initials": "P"}, {"family": "McNair", "given": "Doug", "initials": "D"}, {"family": "Qizilbash", "given": "Nawab", "initials": "N"}, {"family": "Pocock", "given": "Stuart", "initials": "S"}, {"family": "Zariffa", "given": "N\u00e9vine", "initials": "N", "orcid": "0000-0001-7412-2260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b43d74bd08504288860d6a0ad7ea82c3.json"}}], "type": "journal article", "published": "2023-07-19", "journal": {"title": "Clin Transl Sci", "issn": "1752-8062", "issn-l": "1752-8054", "volume": null, "issue": null, "pages": null}, "abstract": "Rapid and robust strategies to evaluate the efficacy and effectiveness of novel and existing pharmacotherapeutic interventions (repurposed treatments) in future pandemics are required. Observational \"real-world studies\" (RWS) can report more quickly than randomized controlled trials (RCTs) and would have value were they to yield reliable results. Both RCTs and RWS were deployed during the coronavirus disease 2019 (COVID-19) pandemic. Comparing results between them offers a unique opportunity to determine the potential value and contribution of each. A learning review of these parallel evidence channels in COVID-19, based on quantitative modeling, can help improve speed and reliability in the evaluation of repurposed therapeutics in a future pandemic. Analysis of all-cause mortality data from 249 observational RWS and RCTs across eight treatment regimens for COVID-19 showed that RWS yield more heterogeneous results, and generally overestimate the effect size subsequently seen in RCTs. This is explained in part by a few study factors: the presence of RWS that are imbalanced for age, gender, and disease severity, and those reporting mortality at 2 weeks or less. Smaller studies of either type contributed negligibly. Analysis of evidence generated sequentially during the pandemic indicated that larger RCTs drive our ability to make conclusive decisions regarding clinical benefit of each treatment, with limited inference drawn from RWS. These results suggest that when evaluating therapies in future pandemics, (1) large RCTs, especially platform studies, be deployed early; (2) any RWS should be large and should have adequate matching of known confounders and long follow-up; (3) reporting standards and data standards for primary endpoints, explanatory factors, and key subgroups should be improved; in addition, (4) appropriate incentives should be in place to enable access to patient-level data; and (5) an overall aggregate view of all available results should be available at any given time.", "doi": "10.1111/cts.13591", "pmid": "37466279", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:10:13.332Z", "modified": "2023-10-04T13:11:17.887Z"}, {"entity": "publication", "iuid": "75b38a566c9a47e8a475fbbdd05169c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/75b38a566c9a47e8a475fbbdd05169c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/75b38a566c9a47e8a475fbbdd05169c5"}}, "title": "Quality of Life in Healthcare Workers during COVID-19-A Longitudinal Study.", "authors": [{"family": "Jungmar Ridell", "given": "Robin", "initials": "R", "orcid": "0009-0001-1877-427X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/248c00c2b3da4b11bb4b7c39e97e899a.json"}}, {"family": "Orvelius", "given": "Lotti", "initials": "L", "orcid": "0000-0002-8641-8656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22194893b9b94b068cda439a33af1b69.json"}}], "type": "journal article", "published": "2023-07-19", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "20", "issue": "14", "pages": null}, "abstract": "The COVID-19 pandemic occurred in 2020, and affected people's daily life worldwide at work and at home. Healthcare workers are a professional group with heavy workloads, and during the COVID-19 pandemic, their burden increased. The literature from earlier outbreaks describes risks for affected mental health in frontline workers, and the main aim of this study is to examine healthcare workers' quality of life during the COVID-19 pandemic. In addition, we sought to assess if there was any difference in working at a pandemic ward compared to anon-pandemic ward. In this longitudinal and descriptive study, a total of 147 healthcare workers assessed their perceived health every third month over one year using the RAND-36 health survey. RAND-36 is a general instrument that consists of 36 questions and is widely used for assessing quality of life. The healthcare workers in this study showed reductions in perceived quality of life during the first six months of the COVID-19 pandemic. Healthcare workers on a pandemic ward reported a lower score in RAND-36 compared to healthcare workers on a non-pandemic ward. Registered nurses and licensed practical nurses seemed more negatively affected in their quality of life than physicians. Compared to data from the general Swedish population, healthcare workers in this study had less energy during this period.", "doi": "10.3390/ijerph20146397", "pmid": "37510629", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10379197"}, {"db": "pii", "key": "ijerph20146397"}], "notes": [], "created": "2023-10-04T12:08:55.593Z", "modified": "2023-10-04T12:45:15.220Z"}, {"entity": "publication", "iuid": "f0d3d0fe64e8498f872585e04df58e78", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f0d3d0fe64e8498f872585e04df58e78.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f0d3d0fe64e8498f872585e04df58e78"}}, "title": "Protective immunity induced by an inhaled SARS-CoV-2 subunit vaccine.", "authors": [{"family": "Elder", "given": "Elizabeth", "initials": "E"}, {"family": "Bangalore Revanna", "given": "Chandrashekar", "initials": "C"}, {"family": "Johansson", "given": "Catharina", "initials": "C"}, {"family": "Wallin", "given": "Robert P A", "initials": "RPA"}, {"family": "Sj\u00f6dahl", "given": "Johan", "initials": "J"}, {"family": "Winqvist", "given": "Ola", "initials": "O"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}], "type": "journal article", "published": "2023-07-19", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null, "volume": "41", "issue": "32", "pages": "4743-4751"}, "abstract": "Targeting the site of infection is a promising strategy for improving vaccine effectivity. To date, licensed COVID-19 vaccines have been administered intramuscularly despite the fact that SARS-CoV-2 is a respiratory virus. Here, we aim to induce local protective mucosal immune responses with an inhaled subunit vaccine candidate, ISR52, based on the SARS-CoV-2 Spike S1 protein. When tested in a lethal challenge hACE2 transgenic SARS-CoV-2 mouse model, intranasal and intratracheal administration of ISR52 provided superior protection against severe infection, compared to the subcutaneous injection of the vaccine. Interestingly for a protein-based vaccine, inhaled ISR52 elicited both CD4 and CD8 T-cell Spike-specific responses that were maintained for at least 6 months in wild-type mice. Induced IgG and IgA responses cross-reacting with several SARS- CoV-2 variants of concern were detected in the lung and in serum and protected animals displayed neutralizing antibodies. Based on our results, we are developing ISR52 as a dry powder formulation for inhalation, that does not require cold-chain distribution or the use of needle administration, for evaluation in a Phase I/II clinical trial.", "doi": "10.1016/j.vaccine.2023.06.015", "pmid": "37353452", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10242152"}, {"db": "pii", "key": "S0264-410X(23)00684-9"}], "notes": [], "created": "2023-10-04T09:29:58.130Z", "modified": "2023-10-04T09:42:25.916Z"}, {"entity": "publication", "iuid": "53d5d83a2a0443efb9a916f3b7ae1622", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53d5d83a2a0443efb9a916f3b7ae1622.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53d5d83a2a0443efb9a916f3b7ae1622"}}, "title": "European Society of Breast Imaging (EUSOBI) guidelines on the management of axillary lymphadenopathy after COVID-19 vaccination: 2023 revision.", "authors": [{"family": "Schiaffino", "given": "Simone", "initials": "S"}, {"family": "Pinker", "given": "Katja", "initials": "K", "orcid": "0000-0002-2722-7331", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a70e813e2dcb4580a6df060773885849.json"}}, {"family": "Cozzi", "given": "Andrea", "initials": "A"}, {"family": "Magni", "given": "Veronica", "initials": "V"}, {"family": "Athanasiou", "given": "Alexandra", "initials": "A"}, {"family": "Baltzer", "given": "Pascal A T", "initials": "PAT"}, {"family": "Camps Herrero", "given": "Julia", "initials": "J"}, {"family": "Clauser", "given": "Paola", "initials": "P"}, {"family": "Fallenberg", "given": "Eva M", "initials": "EM"}, {"family": "Forrai", "given": "Gabor", "initials": "G"}, {"family": "Fuchsj\u00e4ger", "given": "Michael H", "initials": "MH"}, {"family": "Gilbert", "given": "Fiona J", "initials": "FJ"}, {"family": "Helbich", "given": "Thomas", "initials": "T"}, {"family": "Kilburn-Toppin", "given": "Fleur", "initials": "F"}, {"family": "Kuhl", "given": "Christiane K", "initials": "CK"}, {"family": "Lesaru", "given": "Mihai", "initials": "M"}, {"family": "Mann", "given": "Ritse M", "initials": "RM"}, {"family": "Panizza", "given": "Pietro", "initials": "P"}, {"family": "Pediconi", "given": "Federica", "initials": "F"}, {"family": "Sardanelli", "given": "Francesco", "initials": "F"}, {"family": "Sella", "given": "Tamar", "initials": "T"}, {"family": "Thomassin-Naggara", "given": "Isabelle", "initials": "I"}, {"family": "Zackrisson", "given": "Sophia", "initials": "S"}, {"family": "Pijnappel", "given": "Ruud M", "initials": "RM"}], "type": "journal article", "published": "2023-07-19", "journal": {"title": "Insights Imaging", "issn": "1869-4101", "issn-l": null, "volume": "14", "issue": "1", "pages": "126"}, "abstract": "Axillary lymphadenopathy is a common side effect of COVID-19 vaccination, leading to increased imaging-detected asymptomatic and symptomatic unilateral axillary lymphadenopathy. This has threatened to negatively impact the workflow of breast imaging services, leading to the release of ten recommendations by the European Society of Breast Imaging (EUSOBI) in August 2021. Considering the rapidly changing scenario and data scarcity, these initial recommendations kept a highly conservative approach. As of 2023, according to newly acquired evidence, EUSOBI proposes the following updates, in order to reduce unnecessary examinations and avoid delaying necessary examinations. First, recommendation n. 3 has been revised to state that breast examinations should not be delayed or rescheduled because of COVID-19 vaccination, as evidence from the first pandemic waves highlights how delayed or missed screening tests have a negative effect on breast cancer morbidity and mortality, and that there is a near-zero risk of subsequent malignant findings in asymptomatic patients who have unilateral lymphadenopathy and no suspicious breast findings. Second, recommendation n. 7 has been revised to simplify follow-up strategies: in patients without breast cancer history and no imaging findings suspicious for cancer, symptomatic and asymptomatic imaging-detected unilateral lymphadenopathy on the same side of recent COVID-19 vaccination (within 12 weeks) should be classified as a benign finding (BI-RADS 2) and no further work-up should be pursued. All other recommendations issued by EUSOBI in 2021 remain valid.", "doi": "10.1186/s13244-023-01453-2", "pmid": "37466753", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Imaging": null}, "xrefs": [{"db": "pmc", "key": "PMC10356714"}, {"db": "pii", "key": "10.1186/s13244-023-01453-2"}], "notes": [], "created": "2023-10-04T12:10:08.468Z", "modified": "2023-10-04T13:09:53.088Z"}, {"entity": "publication", "iuid": "f224c212d8b649c6930ea0c2c55cb72c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f224c212d8b649c6930ea0c2c55cb72c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f224c212d8b649c6930ea0c2c55cb72c"}}, "title": "A novel indicator of selection in utero.", "authors": [{"family": "Catalano", "given": "Ralph", "initials": "R", "orcid": "0000-0001-7240-415X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ccf81f67c4f46dc92acca88a7344cc9.json"}}, {"family": "Bruckner", "given": "Tim A", "initials": "TA"}, {"family": "Gemmill", "given": "Alison", "initials": "A", "orcid": "0000-0001-5879-9730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dca36e3db9724dce8360c5f7b362151d.json"}}, {"family": "Casey", "given": "Joan A", "initials": "JA", "orcid": "0000-0002-9809-4695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e83f9b0e8a194572a5769025b1fe611f.json"}}, {"family": "Margerison", "given": "Claire", "initials": "C", "orcid": "0000-0003-0692-2252", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06be6014da274b2886af1733870d98b0.json"}}, {"family": "Hartig", "given": "Terry", "initials": "T"}], "type": "journal article", "published": "2023-07-19", "journal": {"title": "Evol Med Public Health", "issn": "2050-6201", "issn-l": null, "volume": "11", "issue": "1", "pages": "244-250"}, "abstract": "Selection in utero predicts that population stressors raise the standard for how quickly fetuses must grow to avoid spontaneous abortion. Tests of this prediction must use indirect indicators of fetal loss in birth cohorts because vital statistics systems typically register fetal deaths at the 20th week of gestation or later, well after most have occurred. We argue that tests of selection in utero would make greater progress if researchers adopted an indicator of selection against slow-growing fetuses that followed from theory, allowed sex-specific tests and used readily available data. We propose such an indicator and assess its validity as a dependent variable by comparing its values among monthly birth cohorts before, and during, the first 10 months of the COVID-19 pandemic in Sweden.\r\n\r\nWe apply Box-Jenkins methods to 50 pre-pandemic birth cohorts (i.e., December 2016 through January 2020) and use the resulting transfer functions to predict counterfactual values in our suggested indicator for selection for ten subsequent birth cohorts beginning in February 2020. We then plot all 60 residual values as well as their 95% detection interval. If birth cohorts in gestation at the onset of the pandemic lost more slow-growing fetuses than expected from history, more than one of the last 10 (i.e. pandemic-exposed) residuals would fall below the detection interval.\r\n\r\nFour of the last 10 residuals of our indicator for males and for females fell below the 95% detection interval.\r\n\r\nConsistent with selection in utero, Swedish birth cohorts in gestation at the outset of the COVID-19 pandemic included fewer than expected infants who grew slowly in utero.", "doi": "10.1093/emph/eoad018", "pmid": "37485055", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10360163"}, {"db": "pii", "key": "eoad018"}], "notes": [], "created": "2023-10-04T12:10:36.917Z", "modified": "2023-10-04T13:27:54.501Z"}, {"entity": "publication", "iuid": "861bb5ecaf5e4ceca3d0fe78c08c0c07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/861bb5ecaf5e4ceca3d0fe78c08c0c07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/861bb5ecaf5e4ceca3d0fe78c08c0c07"}}, "title": "Relative effectiveness of monovalent and bivalent mRNA boosters in preventing severe COVID-19 due to omicron BA.5 infection up to 4 months post-administration in people aged 60 years or older in Italy: a retrospective matched cohort study.", "authors": [{"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Sacco", "given": "Chiara", "initials": "C"}, {"family": "Fotakis", "given": "Emmanouil Alexandros", "initials": "EA"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Bressi", "given": "Marco", "initials": "M"}, {"family": "Rota", "given": "Maria Cristina", "initials": "MC"}, {"family": "Petrone", "given": "Daniele", "initials": "D"}, {"family": "Siddu", "given": "Andrea", "initials": "A"}, {"family": "Fedele", "given": "Giorgio", "initials": "G"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Palamara", "given": "Anna Teresa", "initials": "AT"}, {"family": "Brusaferro", "given": "Silvio", "initials": "S"}, {"family": "Rezza", "given": "Giovanni", "initials": "G"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}], "type": "journal article", "published": "2023-07-18", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Limited evidence is available on the additional protection conferred by second mRNA vaccine boosters against severe COVID-19 caused by omicron BA.5 infection, and whether the adapted bivalent boosters provide additional protection compared with the monovalent ones. In this study, we aimed to estimate the relative effectiveness of a second booster with monovalent or bivalent mRNA vaccines against severe COVID-19 in Italy.\r\n\r\nLinking data from the Italian vaccination registry and the SARS-CoV-2 surveillance system, between Sept 12, 2022, and Jan 7, 2023, we matched 1:1 each person aged 60 years or older receiving a second booster with a person who had received the first booster only at least 120 days earlier. We used hazard ratios, estimated through Cox proportional hazard models, to compare the hazard of severe COVID-19 between the first booster group and each type of second booster (monovalent mRNA vaccine targeting the original strain of SARS-CoV-2, bivalent mRNA vaccine targeting the original strain plus omicron BA.1 [bivalent original/BA.1], and bivalent mRNA vaccine targeting the original strain plus omicron BA.4 and BA.5 [bivalent original/BA.4-5]). Relative vaccine effectiveness (rVE) was calculated as (1-hazard ratio) \u00d7 100.\r\n\r\nWe analysed a total of 2 129 559 matched pairs. The estimated rVE against severe COVID-19 with the bivalent original/BA.4-5 booster was 50\u00b76% (95% CI 46\u00b70-54\u00b78) in the overall time interval 14-118 days post-administration. Overall, rVE was 49\u00b73% (43\u00b76-54\u00b74) for the bivalent original/BA.1 booster and 26\u00b79% (11\u00b78-39\u00b73) for the monovalent booster. For the bivalent original/BA.4-5 booster, we did not observe relevant differences in rVE between the 60-79-year age group (overall, 53\u00b76%; 46\u00b78-59\u00b75) and those aged 80 years or older (overall, 48\u00b73%; 41\u00b79-54\u00b70).\r\n\r\nThese findings suggest that a second booster with mRNA vaccines provides additional protection against severe COVID-19 due to omicron BA.5 (the predominant circulating subvariant in Italy during the study period) in people aged 60 years or older. Although rVE decreased over time, a second booster with the original/BA.4-5 mRNA vaccine, currently the most used in Italy, was found to be still providing protection 4 months post-administration.\r\n\r\nNextGenerationEU-MUR-PNRR Extended Partnership initiative on Emerging Infectious Diseases (project number PE00000007, INF-ACT).\r\n\r\nFor the Italian translation of the abstract see Supplementary Materials section.", "doi": "10.1016/S1473-3099(23)00374-2", "pmid": "37478877", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(23)00374-2"}], "notes": [], "created": "2023-10-04T12:08:12.943Z", "modified": "2023-10-04T12:30:26.922Z"}, {"entity": "publication", "iuid": "a06d396df52745dfb22dc30368de75ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a06d396df52745dfb22dc30368de75ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a06d396df52745dfb22dc30368de75ef"}}, "title": "Practices of Care in Participatory Design With Older Adults During the COVID-19 Pandemic: Digitally Mediated Study.", "authors": [{"family": "Paluch", "given": "Richard", "initials": "R", "orcid": "0000-0003-0420-7028", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50123f4f07fd4f9bac7aec9cfaaa4618.json"}}, {"family": "Cerna", "given": "Katerina", "initials": "K", "orcid": "0000-0001-8796-343X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31750b30f1584f33abd4e31d8fac84a2.json"}}, {"family": "Kirschsieper", "given": "Dennis", "initials": "D", "orcid": "0009-0000-9081-0418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e3bc92c91af411eb29cfbb736e98389.json"}}, {"family": "M\u00fcller", "given": "Claudia", "initials": "C", "orcid": "0000-0001-8534-546X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06fab12a9dd148a3b68fc7f2524d5272.json"}}], "type": "journal article", "published": "2023-07-17", "journal": {"title": "J Med Internet Res", "issn": "1438-8871", "issn-l": null, "volume": "25", "issue": null, "pages": "e45750"}, "abstract": "Participatory Design (PD), albeit an established approach in User-Centered Design, comes with specific challenges when working with older adults as research participants. Addressing these challenges relates to the reflection and negotiation of the positionalities of the researchers and research participants and includes various acts of giving and receiving help. During the COVID-19 pandemic, facets of positionalities and (mutual) care became particularly evident in qualitative and participatory research settings.\r\n\r\nThe aim of this paper was to systematically analyze care practices of participatory (design) research, which are to different extents practices of the latter. Using a multiyear PD project with older people that had to take place remotely over many months, we specify different practices of care; how they relate to collaborative work in the design project; and represent foundational practices for sustainable, long-term co-design. Our research questions were \"How can digitally-mediated PD work during COVID-19 and can we understand such digital PD as 'care'?\"\r\n\r\nOur data comes from the Joint Programming Initiative \"More Years, Better Lives\" (JPI MYBL), a European Union project that aims to promote digital literacy and technology appropriation among older adults in domestic settings. It targeted the cocreation, by older adults and university researchers, of a mobile demo kit website with cocreated resources, aimed at improving the understanding of use options of digital tools. Through a series of workshops, a range of current IT products was explored by a group of 21 older adults, which served as the basis for joint cocreative work on generating design ideas and prototypes. We reflect on the PD process and examine how the actors enact and manifest care.\r\n\r\nThe use of digital technology allowed the participatory project to continue during the COVID-19 pandemic and accentuated the digital skills of older adults and the improvement of digital literacy as part of \"care.\" We provide empirically based evidence of PD with older adults developing digital literacy and sensitizing concepts, based on the notion of care by Tronto for differentiating aspects and processes of care. The data suggest that it is not enough to focus solely on the technologies and how they are used; it is also necessary to focus on the social structures in which help is available and in which technologies offer opportunities to do care work.\r\n\r\nWe document that the cocreation of different digital media tools can be used to provide a community with mutual care. Our study demonstrates how research participants effectively enact different forms of care and how such \"care\" is a necessary basis for a genuinely participatory approach, which became especially meaningful as a form of support during COVID-19. We reflect on how notions of \"care\" and \"caring\" that were central to the pandemic response are also central to PD.", "doi": "10.2196/45750", "pmid": "37459177", "labels": {"Category: Health": null, "Type: Journal article": null, "Funder: H2020": null}, "xrefs": [{"db": "pmc", "key": "PMC10390970"}, {"db": "pii", "key": "v25i1e45750"}], "notes": [], "created": "2023-10-04T12:09:48.554Z", "modified": "2023-10-04T13:02:21.842Z"}, {"entity": "publication", "iuid": "a6a1b3cc2625453bb09de11b4df67c4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6a1b3cc2625453bb09de11b4df67c4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6a1b3cc2625453bb09de11b4df67c4d"}}, "title": "Comparing severe COVID-19 outcomes of first and second/third waves: a prospective single-centre cohort study of health-related quality of life and pulmonary outcomes 6 months after infection.", "authors": [{"family": "Darlington", "given": "Pernilla", "initials": "P", "orcid": "0000-0002-3411-8838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ded6431af104890a284d0cd458bd8d4.json"}}, {"family": "Ro\u00ebl", "given": "Mari", "initials": "M"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Hanna", "given": "Gabriel", "initials": "G"}, {"family": "Hedman", "given": "Anders", "initials": "A"}, {"family": "Joelsson-Alm", "given": "Eva", "initials": "E"}, {"family": "Schandl", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2023-07-17", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "7", "pages": "e071394"}, "abstract": "We aimed to compare long-term outcomes in intensive care unit (ICU) survivors between the first and second/third waves of the COVID-19 pandemic. More specifically, to assess health-related quality of life (HRQL) and respiratory health 6 months post-ICU and to study potential associations between patient characteristic and treatment variables regarding 6-month outcomes.\r\n\r\nProspective cohort study.\r\n\r\nSingle-centre study of adult COVID-19 patients with respiratory distress admitted to two Swedish ICUs during the first wave (1 March 2020-1 September 2020) and second/third waves (2 September 2020- 1 August 2021) with follow-up approximately 6 months after ICU discharge.\r\n\r\nCritically ill COVID-19 patients who survived for at least 90 days.\r\n\r\nHRQL, extent of residual changes on chest CT scan and pulmonary function were compared between the waves. General linear regression and multivariable logistic regression were used to present mean score differences (MSD) and ORs with 95% CIs.\r\n\r\nOf the 456 (67%) critically ill COVID-19 patients who survived at least 90 days, 278 (61%) were included in the study. Six months after ICU discharge, HRQL was similar between survivors in the pandemic waves, except that the second/third wave survivors had better role physical (MSD 20.2, 95% CI 7.3 to 33.1, p<0.01) and general health (MSD 7.2, 95% CI 0.7 to 13.6, p=0.03) and less bodily pain (MSD 12.2, 95% CI 3.6 to 20.8, p<0.01), while first wave survivors had better diffusing capacity of the lungs for carbon monoxide (OR 1.9, 95% CI 1.1 to 3.5, p=0.03).\r\n\r\nThis study indicates that even though intensive care treatment strategies have changed with time, there are few differences in long-term HRQL and respiratory health seems to remain at 6 months for patients surviving critical COVID-19 in the first and second/third waves of the pandemic.", "doi": "10.1136/bmjopen-2022-071394", "pmid": "37460259", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10357304"}, {"db": "pii", "key": "bmjopen-2022-071394"}], "notes": [], "created": "2023-10-04T12:09:03.426Z", "modified": "2023-10-04T12:48:03.979Z"}, {"entity": "publication", "iuid": "66216a329eff46a9a193603cec068305", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66216a329eff46a9a193603cec068305.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66216a329eff46a9a193603cec068305"}}, "title": "Organised crisis volunteers, COVID-19, and the political steering of crisis management in Sweden.", "authors": [{"family": "Wimelius", "given": "Malin E", "initials": "ME"}, {"family": "Strandh", "given": "Veronica", "initials": "V"}], "type": "journal article", "published": "2023-07-14", "journal": {"title": "Disasters", "issn": "1467-7717", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "This paper explores and analyses the activities of Swedish organised crisis volunteers during the COVID-19 pandemic. Based on a questionnaire and interviews, it sets out to answer two research questions on what characterised organised volunteerism during the pandemic, how organised volunteers experienced cooperation with local public actors, and how they viewed political steering. The paper contributes to a growing literature on the role of volunteers and links that role to views on political steering, something that is rarely done in disaster research. Sweden is a useful case study because of how COVID-19 was managed, as well as because there are organised crisis volunteers and a debate is occurring on how the national system is steered. The paper shows how organised volunteers adapted to changing needs and adopted new roles, that experiences of cooperation with local authorities varied, and that calls were made for a stronger national leadership and for more explicit central political steering.", "doi": "10.1111/disa.12604", "pmid": "37450584", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:09:22.610Z", "modified": "2023-10-04T12:51:45.561Z"}, {"entity": "publication", "iuid": "02e7c304712a42c0a4343afa18dbbaf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02e7c304712a42c0a4343afa18dbbaf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02e7c304712a42c0a4343afa18dbbaf3"}}, "title": "Effect of the COVID-19 pandemic on emergency department attendances for pediatric injuries in Mozambique's central hospitals: an interrupted time series and a comparison within the restriction periods between 2019 and 2020.", "authors": [{"family": "Amado", "given": "Vanda", "initials": "V", "orcid": "0000-0002-8839-984X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e564fcb429b45c8932476d0df8d086f.json"}}, {"family": "Moller", "given": "Jette", "initials": "J"}, {"family": "Couto", "given": "Maria Tereza", "initials": "MT"}, {"family": "Wallis", "given": "Lee", "initials": "L"}, {"family": "Laflamme", "given": "Lucie", "initials": "L"}], "type": "journal article", "published": "2023-07-14", "journal": {"title": "Trauma Surg Acute Care Open", "issn": "2397-5776", "issn-l": null, "volume": "8", "issue": "1", "pages": "e001062"}, "abstract": "Hospital-based studies indicate that restriction measures imposed during the COVID-19 pandemic have affected the number and characteristics of pediatric injuries. However, few studies have been conducted in resource-poor countries. This study aimed to determine whether injury-related emergency department (ED) attendances in Mozambique were affected during the restriction periods in 2020 and how the pattern of injury changed.\r\n\r\nMozambique faced two restriction periods in 2020. An interrupted time series was applied to weekly data of pediatric injuries from the ED records of four central hospitals in Mozambique in 2019 and 2020. Weekly numbers of injuries were modeled using a Poisson regression model to estimate the effect of COVID-19 restrictions on trends over calendar time. Then, for each restriction period, differences in injury mechanisms, severity, need for surgery, and intensive care unit (ICU) attendances were compared between 2019 and 2020.\r\n\r\nDuring the 76 weeks preceding the restrictions, there was a stable trend in ED attendances. The weekly number dropped by 48.7% after implementation of the first restrictions. By the end of 2020, the weekly numbers were back to the levels observed before the restrictions. Road traffic injuries (RTIs) and falls dropped during the first restriction period and RTIs and burns during the second. There was an increase of 80% in ICU attendances in all periods of 2020 at three hospitals during the first and second restriction periods.\r\n\r\nThe COVID-19 restrictions yielded a reduction in the weekly number of pediatric injuries seen at Mozambique's central hospitals, above all RTIs and falls. The drop reflects reductions in visits most importantly for RTIs, falls, and burns, but was accompanied by an increase in the proportion of ICU cases. This effect was not maintained when the restrictions were relaxed. Whether this reflects reduced exposure to injury or hesitancy to seek care remains to be determined.\r\n\r\nLevel III, retrospective study with up to two negative criteria.", "doi": "10.1136/tsaco-2022-001062", "pmid": "37484836", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10350904"}, {"db": "pii", "key": "tsaco-2022-001062"}], "notes": [], "created": "2023-10-04T12:10:28.808Z", "modified": "2023-10-04T13:14:11.870Z"}, {"entity": "publication", "iuid": "5711df6665da4420973aa4d6e5d0592e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5711df6665da4420973aa4d6e5d0592e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5711df6665da4420973aa4d6e5d0592e"}}, "title": "The influence of COVID-19 risk perception and vaccination status on the number of social contacts across Europe: insights from the CoMix study.", "authors": [{"family": "Wambua", "given": "James", "initials": "J"}, {"family": "Loedy", "given": "Neilshan", "initials": "N"}, {"family": "Jarvis", "given": "Christopher I", "initials": "CI"}, {"family": "Wong", "given": "Kerry L M", "initials": "KLM"}, {"family": "Faes", "given": "Christel", "initials": "C"}, {"family": "Grah", "given": "Rok", "initials": "R"}, {"family": "Prasse", "given": "Bastian", "initials": "B"}, {"family": "Sandmann", "given": "Frank", "initials": "F"}, {"family": "Niehus", "given": "Rene", "initials": "R"}, {"family": "Johnson", "given": "Helen", "initials": "H"}, {"family": "Edmunds", "given": "W John", "initials": "WJ"}, {"family": "Beutels", "given": "Philippe", "initials": "P"}, {"family": "Hens", "given": "Niel", "initials": "N"}, {"family": "Coletti", "given": "Pietro", "initials": "P"}], "type": "journal article", "published": "2023-07-13", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "23", "issue": "1", "pages": "1350"}, "abstract": "The SARS-CoV-2 transmission dynamics have been greatly modulated by human contact behaviour. To curb the spread of the virus, global efforts focused on implementing both Non-Pharmaceutical Interventions (NPIs) and pharmaceutical interventions such as vaccination. This study was conducted to explore the influence of COVID-19 vaccination status and risk perceptions related to SARS-CoV-2 on the number of social contacts of individuals in 16 European countries.\r\n\r\nWe used data from longitudinal surveys conducted in the 16 European countries to measure social contact behaviour in the course of the pandemic. The data consisted of representative panels of participants in terms of gender, age and region of residence in each country. The surveys were conducted in several rounds between December 2020 and September 2021 and comprised of 29,292 participants providing a total of 111,103 completed surveys. We employed a multilevel generalized linear mixed effects model to explore the influence of risk perceptions and COVID-19 vaccination status on the number of social contacts of individuals.\r\n\r\nThe results indicated that perceived severity played a significant role in social contact behaviour during the pandemic after controlling for other variables (p-value < 0.001). More specifically, participants who had low or neutral levels of perceived severity reported 1.25 (95% Confidence intervals (CI) 1.13 - 1.37) and 1.10 (95% CI 1.00 - 1.21) times more contacts compared to those who perceived COVID-19 to be a serious illness, respectively. Additionally, vaccination status was also a significant predictor of contacts (p-value < 0.001), with vaccinated individuals reporting 1.31 (95% CI 1.23 - 1.39) times higher number of contacts than the non-vaccinated. Furthermore, individual-level factors played a more substantial role in influencing contact behaviour than country-level factors.\r\n\r\nOur multi-country study yields significant insights on the importance of risk perceptions and vaccination in behavioral changes during a pandemic emergency. The apparent increase in social contact behaviour following vaccination would require urgent intervention in the event of emergence of an immune escaping variant.", "doi": "10.1186/s12889-023-16252-z", "pmid": "37442987", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Social Science & Humanities": null, "Funder: H2020": null}, "xrefs": [{"db": "pmc", "key": "PMC10347859"}, {"db": "pii", "key": "10.1186/s12889-023-16252-z"}], "notes": [], "created": "2023-10-04T12:08:18.368Z", "modified": "2023-10-04T12:32:22.312Z"}, {"entity": "publication", "iuid": "8ecaa819bcdc4d49b92adfe225613ff0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ecaa819bcdc4d49b92adfe225613ff0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ecaa819bcdc4d49b92adfe225613ff0"}}, "title": "Individual-level precision diagnosis for coronavirus disease 2019 related severe outcome: an early study in New York.", "authors": [{"family": "Huang", "given": "Chaorui C", "initials": "CC"}, {"family": "Xu", "given": "Hong", "initials": "H"}], "type": "journal article", "published": "2023-07-13", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "11317"}, "abstract": "Because of inadequate information provided by the on-going population level risk analyses for Coronavirus disease 2019 (COVID-19), this study aimed to evaluate the risk factors and develop an individual-level precision diagnostic method for COVID-19 related severe outcome in New York State (NYS) to facilitate early intervention and predict resource needs for patients with COVID-19. We analyzed COVID-19 related hospital encounter and hospitalization in NYS using Statewide Planning and Research Cooperative System hospital discharge dataset. Logistic regression was performed to evaluate the risk factors for COVID-19 related mortality. We proposed an individual-level precision diagnostic method by taking into consideration of the different weights and interactions of multiple risk factors. Age was the greatest risk factor for COVID-19 related fatal outcome. By adding other demographic variables, dyspnea or hypoxemia and multiple chronic co-morbid conditions, the model predictive accuracy was improved to 0.85 (95% CI 0.84-0.85). We selected cut-off points for predictors and provided a general recommendation to categorize the levels of risk for COVID-19 related fatal outcome, which can facilitate the individual-level diagnosis and treatment, as well as medical resource prediction. We further provided a use case of our method to evaluate the feasibility of public health policy for monoclonal antibody therapy.", "doi": "10.1038/s41598-023-35966-z", "pmid": "37443363", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10344938"}, {"db": "pii", "key": "10.1038/s41598-023-35966-z"}], "notes": [], "created": "2023-10-04T12:08:20.888Z", "modified": "2023-10-04T12:33:28.301Z"}, {"entity": "publication", "iuid": "0a3a113ae8d94215aa2d5d077722c049", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a3a113ae8d94215aa2d5d077722c049.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a3a113ae8d94215aa2d5d077722c049"}}, "title": "Post COVID-19 symptoms are common, also among young adults in the general population.", "authors": [{"family": "Mogensen", "given": "Ida", "initials": "I"}, {"family": "Ekstr\u00f6m", "given": "Sandra", "initials": "S"}, {"family": "Hallberg", "given": "Jenny", "initials": "J"}, {"family": "Georgelis", "given": "Antonios", "initials": "A"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Bergstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Kull", "given": "Inger", "initials": "I"}], "type": "journal article", "published": "2023-07-12", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "11300"}, "abstract": "Post coronavirus disease-19 (post COVID-19) is mainly studied in clinical populations and less is known about post COVID-19 in a young general population. The aim of the study is to investigate the prevalence and symptoms of post COVID-19 and its potential risk factors in young adults. Participants from the Swedish population-based birth cohort BAMSE were included (n = 2022, mean age 26.5 years). Post COVID-19 was assessed through a questionnaire and defined as symptoms after confirmed COVID-19 (registry-based or self-reported positive test) lasting for \u2265 2 months. In total, 681 participants had had confirmed COVID-19. Among them, 112 (16.5%) fulfilled the definition of post COVID-19 (17.8% in females, 14.5% in males, p = 0.26). The most common post COVID-19 symptoms were altered smell and taste (68.8%), dyspnea (33.7%) and fatigue (30.4%). Overall, no major risk factors for post COVID-19 were identified except for being bedbound during COVID-19. However, asthma and rhinitis were associated with the post COVID-19 symptom dyspnea, migraine with altered smell and taste, and lower self-rated health with fatigue. In conclusion, post COVID-19 symptoms are common, also among young adults in the general population. Although not life-threatening, it could have a considerable impact on public health due to the high prevalence and long-term symptoms.", "doi": "10.1038/s41598-023-38315-2", "pmid": "37438424", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC10338459"}, {"db": "pii", "key": "10.1038/s41598-023-38315-2"}], "notes": [], "created": "2023-07-13T11:31:58.051Z", "modified": "2023-10-04T12:29:26.665Z"}, {"entity": "publication", "iuid": "24523286d51a489ab3267bcf49c947b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24523286d51a489ab3267bcf49c947b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24523286d51a489ab3267bcf49c947b4"}}, "title": "Lessons from COVID-19 for Pandemic Preparedness: Proceedings from a Multi-Stakeholder Think Tank.", "authors": [{"family": "Narayanasamy", "given": "Shanti", "initials": "S", "orcid": "0000-0002-6667-2868", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53cc5ca9db8d49678370dbaad3d91ac0.json"}}, {"family": "Curtis", "given": "Lesley H", "initials": "LH"}, {"family": "Hernandez", "given": "Adrian F", "initials": "AF"}, {"family": "Woods", "given": "Christopher W", "initials": "CW"}, {"family": "Moody", "given": "M Anthony", "initials": "MA"}, {"family": "Sulkowski", "given": "Mark", "initials": "M"}, {"family": "Turbett", "given": "Sarah E", "initials": "SE"}, {"family": "Baden", "given": "Lindsey R", "initials": "LR"}, {"family": "Gulick", "given": "Roy M", "initials": "RM"}, {"family": "Pau", "given": "Alice K", "initials": "AK"}, {"family": "Adam", "given": "Stacey J", "initials": "SJ"}, {"family": "Marks", "given": "Peter", "initials": "P"}, {"family": "Stockbridge", "given": "Norman L", "initials": "NL"}, {"family": "Dobbins", "given": "John R", "initials": "JR"}, {"family": "Krofah", "given": "Esther", "initials": "E"}, {"family": "Leav", "given": "Brett", "initials": "B"}, {"family": "Pang", "given": "Phil", "initials": "P"}, {"family": "Roessig", "given": "Lothar", "initials": "L"}, {"family": "Vedin", "given": "Ola", "initials": "O"}, {"family": "Waldstreicher", "given": "Joanne", "initials": "J"}, {"family": "Berman", "given": "Stacey Cromer", "initials": "SC"}, {"family": "Cremisi", "given": "Henry", "initials": "H"}, {"family": "Schofield", "given": "Lesley", "initials": "L"}, {"family": "Gandhi", "given": "Rajesh T", "initials": "RT"}, {"family": "Naggie", "given": "Susanna", "initials": "S"}], "type": "journal article", "published": "2023-07-12", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "issn-l": "1058-4838", "volume": null, "issue": null, "pages": null}, "abstract": "While the Coronavirus Disease 2019 (COVID-19) pandemic continues to present global challenges, sufficient time has passed to reflect on lessons learned and use those insights to inform policy and approaches to prepare for the next pandemic. In May 2022, the Duke Clinical Research Institute (DCRI) convened a Think Tank with thought-leaders from academia, clinical practice, the pharmaceutical industry, patient advocacy, the National Institutes of Health, the US Food and Drug Administration (FDA), and Centers for Disease Control and Prevention (CDC), to share firsthand, expert knowledge of the insights gained from the COVID-19 pandemic and how this acquired knowledge can help inform the next pandemic response. The Think Tank focused on pandemic preparedness, therapeutics, vaccines, and challenges related to clinical trial design and scale-up during the early phase of a pandemic. Based on the multi-faceted discussions, we outline ten key steps to an improved and equitable pandemic response.", "doi": "10.1093/cid/ciad418", "pmid": "37435958", "labels": {"Category: Other": null, "Type: Other": null}, "xrefs": [{"db": "pii", "key": "7223127"}], "notes": [], "created": "2023-10-04T12:10:24.038Z", "modified": "2023-10-04T13:12:14.203Z"}, {"entity": "publication", "iuid": "f0eee6262116469689fc2cacd6e9a821", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f0eee6262116469689fc2cacd6e9a821.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f0eee6262116469689fc2cacd6e9a821"}}, "title": "Additive effects of booster mRNA vaccination and SARS-CoV-2 Omicron infection on T cell immunity across immunocompromised states.", "authors": [{"family": "M\u00fcller", "given": "Thomas R", "initials": "TR", "orcid": "0000-0001-5331-5522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28e705f82ca64e698015b577d25e991c.json"}}, {"family": "Sekine", "given": "Takuya", "initials": "T", "orcid": "0000-0001-7649-0593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a234e0d77c145aa8d23b89fde1c5883.json"}}, {"family": "Trubach", "given": "Darya", "initials": "D", "orcid": "0009-0005-7445-9281", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09dcd62967fe432bbc292f3a10f0458d.json"}}, {"family": "Niessl", "given": "Julia", "initials": "J", "orcid": "0000-0001-8852-1924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70aba42c7f0b400eba1a226ee193d9fd.json"}}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Bergman", "given": "Peter", "initials": "P", "orcid": "0000-0003-3306-3713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15b7290255814a7b9a1a97c3cdb2fc26.json"}}, {"family": "Blennow", "given": "Ola", "initials": "O", "orcid": "0000-0002-7167-7882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2318c3973e66443aa14fceca0908d127.json"}}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Mielke", "given": "Stephan", "initials": "S", "orcid": "0000-0002-8325-9215", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6f17a7cc4774614a3ad5ea9c910d75a.json"}}, {"family": "Nowak", "given": "Piotr", "initials": "P", "orcid": "0000-0003-2747-0734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1d81fdccf9e424fa99ea5227b031843.json"}}, {"family": "Vesterbacka", "given": "Jan", "initials": "J"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Olofsson", "given": "Anna", "initials": "A", "orcid": "0000-0002-7479-315X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b3cfdb6d9cc47e2ad2377d5fe51ca4a.json"}}, {"family": "Amaya Hernandez", "given": "Susana Patricia", "initials": "SP", "orcid": "0000-0003-4425-8145", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a28fef26f85d42d88cea8ea68ba0c7d0.json"}}, {"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Cai", "given": "Curtis", "initials": "C", "orcid": "0000-0002-3490-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52ab789751014f46b6b995a1cdef57a3.json"}}, {"family": "S\u00f6derdahl", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-4423-2458", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e23b3e831934cd786a15cb2183e810e.json"}}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE", "orcid": "0000-0003-1907-3392", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26a3bf24bd044fbda8ffa0c89974bdfe.json"}}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K", "orcid": "0000-0001-7679-9494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02d4d3d9ccc547f7ab18ba69493f6a34.json"}}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M", "orcid": "0000-0002-3793-4064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4bc179656eb442f9ac9dc72c8c6841d.json"}}, {"family": "Ljungman", "given": "Per", "initials": "P", "orcid": "0000-0002-8281-3245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4546eb504184683ab712eee858ea9cb.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Karlsson", "given": "Annika C", "initials": "AC", "orcid": "0000-0002-2028-8393", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9abf28110888427497db1e4abf6ff71d.json"}}, {"family": "Saini", "given": "Sunil Kumar", "initials": "SK", "orcid": "0000-0003-3382-9432", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ad140b13bdd4cd68cf422454b24c29f.json"}}, {"family": "Aleman", "given": "Soo", "initials": "S", "orcid": "0000-0003-0461-4870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b0edb2db8d840989936f67047ce91de.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}], "type": "journal article", "published": "2023-07-12", "journal": {"title": "Sci Transl Med", "issn": "1946-6242", "issn-l": null, "volume": "15", "issue": "704", "pages": "eadg9452"}, "abstract": "Suboptimal immunity to SARS-CoV-2 mRNA vaccination has frequently been observed in individuals with various immunodeficiencies. Given the increased antibody evasion properties of emerging SARS-CoV-2 subvariants, it is necessary to assess whether other components of adaptive immunity generate resilient and protective responses against infection. We assessed T cell responses in 279 individuals, covering five different immunodeficiencies and healthy controls, before and after booster mRNA vaccination, as well as after Omicron infection in a subset of patients. We observed robust and persistent Omicron-reactive T cell responses that increased markedly upon booster vaccination and correlated directly with antibody titers across all patient groups. Poor vaccination responsiveness in immunocompromised or elderly individuals was effectively counteracted by the administration of additional vaccine doses. Functionally, Omicron-reactive T cell responses exhibited a pronounced cytotoxic profile and signs of longevity, characterized by CD45RA+ effector memory subpopulations with stem cell-like properties and increased proliferative capacity. Regardless of underlying immunodeficiency, booster-vaccinated and Omicron-infected individuals appeared protected against severe disease and exhibited enhanced and diversified T cell responses against conserved and Omicron-specific epitopes. Our findings indicate that T cells retain the ability to generate highly functional responses against newly emerging variants, even after repeated antigen exposure and a robust immunological imprint from ancestral SARS-CoV-2 mRNA vaccination.", "doi": "10.1126/scitranslmed.adg9452", "pmid": "37437015", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-07-13T11:33:29.721Z", "modified": "2023-10-04T13:10:33.441Z"}, {"entity": "publication", "iuid": "a76734b17d444d2197424cfb38e73d84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a76734b17d444d2197424cfb38e73d84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a76734b17d444d2197424cfb38e73d84"}}, "title": "A design strategy to generate a SARS-CoV-2 RBD vaccine that abrogates ACE2 binding and improves neutralizing antibody responses.", "authors": [{"family": "Ratswohl", "given": "Christoph", "initials": "C", "orcid": "0000-0001-5413-0730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3c10f6df613450abcf5f5bf55a7b781.json"}}, {"family": "V\u00e1zquez Garc\u00eda", "given": "Clara", "initials": "C", "orcid": "0000-0003-4583-7616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/622a5e04069f4e0baedf9c4a21fed629.json"}}, {"family": "Ahmad", "given": "Ata Ul Wakeel", "initials": "AUW", "orcid": "0009-0003-0734-7904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/699b0a9abd014f9b923b0fd1392c9fd2.json"}}, {"family": "Gonschior", "given": "Hannes", "initials": "H", "orcid": "0000-0002-1775-8120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c36380bcaae467aba65ee13d7b0ffac.json"}}, {"family": "Lebedin", "given": "Mikhail", "initials": "M", "orcid": "0000-0002-3877-7195", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c19b8f990f2415aa1646e45343d082d.json"}}, {"family": "Silvis", "given": "Casper Ewijn", "initials": "CE", "orcid": "0009-0005-0433-2197", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee84cb3452784753b662fae0c62e6879.json"}}, {"family": "Spatt", "given": "Lisa", "initials": "L"}, {"family": "Gerhard", "given": "Cathrin", "initials": "C"}, {"family": "Lehmann", "given": "Martin", "initials": "M", "orcid": "0000-0002-8370-6353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ed100612ee3422f97d023858f63405d.json"}}, {"family": "Sander", "given": "Leif E", "initials": "LE", "orcid": "0000-0002-0476-9947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36c4c59d112a4a2dbdc313dcd69c9702.json"}}, {"family": "Kurth", "given": "Florian", "initials": "F", "orcid": "0000-0002-3807-473X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32dfbcb28c674000bb43fefe2938c711.json"}}, {"family": "Olsson", "given": "Simon", "initials": "S", "orcid": "0000-0002-3927-7897", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b6b2b0004ffe46ef8ba4181876a55762.json"}}, {"family": "de la Rosa", "given": "Kathrin", "initials": "K", "orcid": "0000-0003-4809-3157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee415ff0f17846ed8a136217a243409a.json"}}], "type": "journal article", "published": "2023-07-12", "journal": {"title": "Eur J Immunol", "issn": "1521-4141", "issn-l": null, "volume": null, "issue": null, "pages": "e2350408"}, "abstract": "The structure-based design of antigens holds promise for developing vaccines with higher efficacy and improved safety profiles. We postulate that abrogation of host receptor interaction bears potential for the improvement of vaccines by preventing antigen-induced modification of receptor function as well as the displacement or masking of the immunogen. Antigen modifications may yet destroy epitopes crucial for antibody neutralization. Here, we present a methodology that integrates deep mutational scans to identify and score SARS-CoV-2 receptor binding domain variants that maintain immunogenicity, but lack interaction with the widely expressed host receptor. Single point mutations were scored in silico, validated in vitro, and applied in vivo. Our top-scoring variant receptor binding domain-G502E prevented spike-induced cell-to-cell fusion, receptor internalization, and improved neutralizing antibody responses by 3.3-fold in rabbit immunizations. We name our strategy BIBAX for body-inert, B-cell-activating vaccines, which in the future may be applied beyond SARS-CoV-2 for the improvement of vaccines by design.", "doi": "10.1002/eji.202350408", "pmid": "37435628", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:10:39.531Z", "modified": "2023-10-04T13:28:51.730Z"}, {"entity": "publication", "iuid": "0784cfd79da945169d97f806226c1339", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0784cfd79da945169d97f806226c1339.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0784cfd79da945169d97f806226c1339"}}, "title": "Results of the first nationwide cohort study of outcomes in dialysis and kidney transplant patients before and after vaccination for COVID-19.", "authors": [{"family": "Wijkstr\u00f6m", "given": "Julia", "initials": "J", "orcid": "0000-0001-6183-5878", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c90a939ef95648a5812cda3a5769ca78.json"}}, {"family": "Caldinelli", "given": "Aurora", "initials": "A"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A", "orcid": "0000-0002-9752-9941", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86a352b1ff85430daf1cebd1c210d38b.json"}}, {"family": "Nowak", "given": "Alexandra", "initials": "A"}, {"family": "Artborg", "given": "Angelica", "initials": "A"}, {"family": "Stendahl", "given": "Maria", "initials": "M"}, {"family": "Segelmark", "given": "M\u00e5rten", "initials": "M", "orcid": "0000-0002-1221-0772", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39ab2e6d40d441389c037b936eaac574.json"}}, {"family": "Lindholm", "given": "Bengt", "initials": "B"}, {"family": "Bellocco", "given": "Rino", "initials": "R"}, {"family": "Rydell", "given": "Helena", "initials": "H"}, {"family": "Evans", "given": "Marie", "initials": "M", "orcid": "0000-0001-8650-5795", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adad70f1421b4ae49c160017cfba58a1.json"}}], "type": "journal article", "published": "2023-07-11", "journal": {"title": "Nephrol Dial Transplant", "issn": "1460-2385", "issn-l": "0931-0509", "volume": null, "issue": null, "pages": null}, "abstract": "Patients with kidney replacement therapy (KRT) have been identified as a vulnerable group during the COVID-19 pandemic. This study reports the outcomes of COVID-19 in KRT patients in Sweden, a country where patients on KRT were prioritized early in the vaccination campaign.\r\n\r\nPatients with KRT between January 2019 and December 2021 in the Swedish Renal Registry were included. Data were linked to national healthcare registries. The primary outcome was monthly all-cause mortality over three-years follow-up. The secondary outcomes were monthly COVID-19 related deaths and hospitalizations. The results were compared with the general population using standardized mortality ratios. The difference in risk for COVID-19 related outcomes between dialysis and kidney transplant recipients was assessed in multivariable logistic regression models before and after vaccinations started.\r\n\r\nOn January 1, 2020, there were 4097 patients on dialysis (median age 70) and 5905 kidney transplant recipients (median age 58). Between March 2020 and February 2021, mean all-cause mortality rates increased by 10% (from 720 to 804 deaths) and 22% (from 158 to 206 deaths) in dialysis and kidney transplant recipients respectively compared with the same period 2019. After vaccinations started, all-cause mortality rates during the third wave (April 2021) returned to pre COVID-19 mortality rates among dialysis patients, while mortality rates remained increased among transplant recipients. Dialysis patients had a higher risk for COVID-19 hospitalizations and death before vaccinations started aOR 2.1 (95% CI 1.7-2.5), but a lower risk after vaccination, aOR 0.5 (95% CI 0.4-0.7) compared to kidney transplant recipients.\r\n\r\nThe COVID-19 pandemic in Sweden resulted in increased mortality and hospitalization rates among KRT patients. After vaccinations started, a distinct reduction in hospitalization and mortality rates was observed among dialysis patients, but not in kidney transplant recipients. Early and prioritized vaccinations of KRT patients in Sweden probably saved many lives.", "doi": "10.1093/ndt/gfad151", "pmid": "37433606", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "7222920"}], "notes": [], "created": "2023-10-04T12:08:47.555Z", "modified": "2023-10-04T12:40:55.746Z"}, {"entity": "publication", "iuid": "d70c893e2e234b7887b2b8d5b290ecd4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d70c893e2e234b7887b2b8d5b290ecd4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d70c893e2e234b7887b2b8d5b290ecd4"}}, "title": "Predictors of Sustained Physical Activity During the COVID-19 Pandemic in People With Parkinson Disease in Sweden.", "authors": [{"family": "Moulaee Conradsson", "given": "David", "initials": "D"}, {"family": "Leavy", "given": "Breiffni", "initials": "B"}, {"family": "Hagstr\u00f6mer", "given": "Maria", "initials": "M"}, {"family": "Franz\u00e9n", "given": "Erika", "initials": "E"}], "type": "journal article", "published": "2023-07-10", "journal": {"title": "J Neurol Phys Ther", "issn": "1557-0584", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "During the first wave of the COVID-19 pandemic, people with Parkinson disease (PwPD) reported deterioration in health and physical activity. The aim of this study was to describe 1-year changes in physical activity and perceived health in PwPD during the COVID-19 pandemic and to identify predictors of sustained physical activity.\r\n\r\nThis study compared perceived health and sensor-derived physical activity (Actigraph GT3x) in PwPD between the first (June to July 2020) and third waves (June to July 2021) of the pandemic. Multiple logistic regression analyses were used to predict sustained physical activity across the study period using personal factors, disease severity, and functioning as independent variables.\r\n\r\nSixty-three PwPD (mean age 71.0 years, 41% females) completed both baseline and 1-year follow-up (26 lost to follow-up). PwPD showed a decrease in average number of steps per day (\u0394415 steps, P = 0.048), moderate-to-vigorous-physical activity (\u03947 minutes, P = 0.007) and increase in sedentary time (\u039436 minutes, P <.001) between baseline and 1-year follow-up. While self-perceived walking impairments and depressive symptoms increased significantly, balance confidence decreased between baseline and 1-year follow-up, no significant changes occurred for self-rated health, quality of life, or anxiety. Significant predictors of sustained physical activity levels were 15 years or more of education (odds ratio [OR] = 7.38, P = 0.013) and higher perceived walking ability (OR = 0.18, P = 0.041).\r\n\r\nAmong PwPD with mild to moderate disease severity living in Sweden, factors associated with reduced physical activity levels during the COVID-19 pandemic included older age, lower education levels, and greater perceived walking difficulties.Video Abstract available for more insights from the authors (see the Video, the Supplemental Digital Content, available at: http://links.lww.com/JNPT/A451).", "doi": "10.1097/NPT.0000000000000455", "pmid": "37436217", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "01253086-990000000-00045"}], "notes": [], "created": "2023-10-04T12:09:30.076Z", "modified": "2023-10-04T12:54:56.989Z"}, {"entity": "publication", "iuid": "464dfd70bfc3466082fd3a71ab1be22c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/464dfd70bfc3466082fd3a71ab1be22c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/464dfd70bfc3466082fd3a71ab1be22c"}}, "title": "MEDIATE - Molecular DockIng at homE: Turning collaborative simulations into therapeutic solutions.", "authors": [{"family": "Vistoli", "given": "Giulio", "initials": "G"}, {"family": "Manelfi", "given": "Candida", "initials": "C"}, {"family": "Talarico", "given": "Carmine", "initials": "C"}, {"family": "Fava", "given": "Anna", "initials": "A"}, {"family": "Warshel", "given": "Arieh", "initials": "A"}, {"family": "Tetko", "given": "Igor V", "initials": "IV"}, {"family": "Apostolov", "given": "Rossen", "initials": "R"}, {"family": "Ye", "given": "Yang", "initials": "Y"}, {"family": "Latini", "given": "Chiara", "initials": "C"}, {"family": "Ficarelli", "given": "Federico", "initials": "F"}, {"family": "Palermo", "given": "Gianluca", "initials": "G", "orcid": "0000-0001-7955-8012", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c8395c9ce314613b2fca368fc49a2dd.json"}}, {"family": "Gadioli", "given": "Davide", "initials": "D"}, {"family": "Vitali", "given": "Emanuele", "initials": "E"}, {"family": "Varriale", "given": "Gaetano", "initials": "G"}, {"family": "Pisapia", "given": "Vincenzo", "initials": "V"}, {"family": "Scaturro", "given": "Marco", "initials": "M"}, {"family": "Coletti", "given": "Silvano", "initials": "S"}, {"family": "Gregori", "given": "Daniele", "initials": "D"}, {"family": "Gruffat", "given": "Daniel", "initials": "D"}, {"family": "Leija", "given": "Edgardo", "initials": "E"}, {"family": "Hessenauer", "given": "Sam", "initials": "S"}, {"family": "Delbianco", "given": "Alberto", "initials": "A"}, {"family": "Allegretti", "given": "Marcello", "initials": "M"}, {"family": "Beccari", "given": "Andrea R", "initials": "AR"}], "type": "journal article", "published": "2023-07-10", "journal": {"title": "Expert Opin Drug Discov", "issn": "1746-045X", "issn-l": null, "volume": "18", "issue": "8", "pages": "821-833"}, "abstract": "Collaborative computing has attracted great interest in the possibility of joining the efforts of researchers worldwide. Its relevance has further increased during the pandemic crisis since it allows for the strengthening of scientific collaborations while avoiding physical interactions. Thus, the E4C consortium presents the MEDIATE initiative which invited researchers to contribute via their virtual screening simulations that will be combined with AI-based consensus approaches to provide robust and method-independent predictions. The best compounds will be tested, and the biological results will be shared with the scientific community.\r\n\r\nIn this paper, the MEDIATE initiative is described. This shares compounds' libraries and protein structures prepared to perform standardized virtual screenings. Preliminary analyses are also reported which provide encouraging results emphasizing the MEDIATE initiative's capacity to identify active compounds.\r\n\r\nStructure-based virtual screening is well-suited for collaborative projects provided that the participating researchers work on the same input file. Until now, such a strategy was rarely pursued and most initiatives in the field were organized as challenges. The MEDIATE platform is focused on SARS-CoV-2 targets but can be seen as a prototype which can be utilized to perform collaborative virtual screening campaigns in any therapeutic field by sharing the appropriate input files.", "doi": "10.1080/17460441.2023.2221025", "pmid": "37424369", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null, "Funder: H2020": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:12:49.893Z", "modified": "2023-10-04T13:35:51.361Z"}, {"entity": "publication", "iuid": "c4c830abc4d14a30afe060376ff608dc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c4c830abc4d14a30afe060376ff608dc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c4c830abc4d14a30afe060376ff608dc"}}, "title": "COVID-19 risk perception and public compliance with preventive measures: Evidence from a multi-wave household survey in the MENA region.", "authors": [{"family": "Abu Hatab", "given": "Assem", "initials": "A", "orcid": "0000-0002-6764-1887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/555972d8e62042e19e254cc81a9f3743.json"}}, {"family": "Krautscheid", "given": "Lena", "initials": "L"}, {"family": "Amuakwa-Mensah", "given": "Franklin", "initials": "F", "orcid": "0000-0002-3581-4704", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cb40adcc28c419f99e56a827b03ef74.json"}}], "type": "journal article", "published": "2023-07-10", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "7", "pages": "e0283412"}, "abstract": "This study investigates the association between individuals' concern about contracting COVID-19 and their compliance with recommended preventive and mitigation measures, namely wearing face masks, maintaining social distancing and handwashing, in the context of the Middle East and North Africa (MENA) region. The empirical analysis is based on a panel dataset from the Combined COVID-19 MENA Monitor Household Survey, which was carried out in Jordan, Morocco, Sudan, Tunisia and Egypt. Applying a probit estimation technique, a positive and statistically significant association was found between the level of COVID-19 worries and individuals' compliance with the mitigation measures. Notably, the results revealed that this association followed a \"first-up-then-down\" trend, showing that compliance with the three mitigation measures rose as individuals' worries about contracting the virus increased, and then markedly decreased after they had been infected. Socio-demographic characteristics contributing to lower levels of compliance included being male, being over 60, having lower levels of education and having a lower household income. A cross-country analysis revealed remarkable differences between the five countries, with the strongest association between COVID-19 concerns and adherence to mitigation measures observed in Tunisia and Sudan, and the weakest association seen in Jordan and Morocco. Policy implications are outlined for effective risk communication and management during disease outbreaks and public health emergencies to encourage appropriate public health behaviours.", "doi": "10.1371/journal.pone.0283412", "pmid": "37428731", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10332611"}, {"db": "pii", "key": "PONE-D-22-31846"}], "notes": [], "created": "2023-10-04T12:08:50.332Z", "modified": "2023-10-04T12:42:27.896Z"}, {"entity": "publication", "iuid": "a7d0e355c176491a894c755145aea491", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7d0e355c176491a894c755145aea491.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7d0e355c176491a894c755145aea491"}}, "title": "Sociodemographic disparities affect COVID-19 vaccine uptake in non-elderly adults with increased risk of severe COVID-19.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P", "orcid": "0000-0003-3153-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd6af5accfc84ff9a81983a5ab6683aa.json"}}, {"family": "Sotoodeh", "given": "Adonis", "initials": "A"}, {"family": "Askling", "given": "Helena H", "initials": "HH"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P", "orcid": "0000-0002-8185-2648", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78b415aee4864810b8ce8f1962fa288f.json"}}], "type": "journal article", "published": "2023-07-09", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "There is limited information about sociodemographic disparities in COVID-19 vaccine uptake among non-elderly adults with an increased risk of severe COVID-19. We investigated the COVID-19 vaccine uptake in individuals aged 18-64 years with an increased risk of severe COVID-19 (non-elderly risk group) in Stockholm County, Sweden.\r\n\r\nWe used population-based health and sociodemographic registries with high coverage to perform a cohort study of COVID-19 vaccine uptake of one to four doses up until 21 November 2022. The vaccine uptake in the non-elderly risk group was compared with non-risk groups aged 18-64 years (non-elderly non-risk group) and individuals aged \u226565 years (elderly).\r\n\r\nThe uptake of \u22653 vaccine doses was 55%, 64% and 87% in the non-elderly non-risk group (n = 1,005,182), non-elderly risk group (n = 308,904) and elderly (n = 422,604), respectively. Among non-elderly risk group conditions, Down syndrome showed the strongest positive association with receiving three doses (adjusted risk ratio [aRR] 1.62, 95% confidence interval [CI] 1.54-1.71), whereas chronic liver disease showed the strongest negative association (aRR 0.90, 95% CI 0.88-0.92). Higher vaccine uptake among the non-elderly risk group was associated with increasing age, being born in Sweden, higher education, higher income and living in a household where other adults had been vaccinated. Similar trends were observed for the first, second, third and fourth doses.\r\n\r\nThese results call for measures to tackle sociodemographic disparities in vaccination programmes during and beyond the COVID-19 pandemic.", "doi": "10.1111/joim.13700", "pmid": "37424218", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Vaccines": null, "Category: Social Science & Humanities": null, "Funder: H2020": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:08:33.778Z", "modified": "2023-10-04T12:38:05.602Z"}, {"entity": "publication", "iuid": "6e47af3193934ba68696ee3e1a095195", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e47af3193934ba68696ee3e1a095195.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e47af3193934ba68696ee3e1a095195"}}, "title": "Diabetes status and other factors as correlates of risk for thrombotic and thromboembolic events during SARS-CoV-2 infection: A nationwide retrospective case-control study using Cerner Real-World Data\u2122.", "authors": [{"family": "Tallon", "given": "Erin M", "initials": "EM", "orcid": "0000-0003-1353-6632", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84a1b4722f504e2f8b66735df7ae7155.json"}}, {"family": "Gallagher", "given": "Mary Pat", "initials": "MP"}, {"family": "Staggs", "given": "Vincent S", "initials": "VS"}, {"family": "Ferro", "given": "Diana", "initials": "D"}, {"family": "Murthy", "given": "Deepa Badrinath", "initials": "DB"}, {"family": "Ebekozien", "given": "Osagie", "initials": "O"}, {"family": "Kosiborod", "given": "Mikhail N", "initials": "MN"}, {"family": "Lind", "given": "Marcus", "initials": "M"}, {"family": "Manrique-Acevedo", "given": "Camila", "initials": "C"}, {"family": "Shyu", "given": "Chi-Ren", "initials": "C"}, {"family": "Clements", "given": "Mark A", "initials": "MA"}], "type": "journal article", "published": "2023-07-09", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "7", "pages": "e071475"}, "abstract": "We sought to examine in individuals with SARS-CoV-2 infection whether risk for thrombotic and thromboembolic events (TTE) is modified by presence of a diabetes diagnosis. Furthermore, we analysed whether differential risk for TTEs exists in type 1 diabetes mellitus (T1DM) versus type 2 diabetes mellitus (T2DM).\r\n\r\nRetrospective case-control study.\r\n\r\nThe December 2020 version of the Cerner Real-World Data COVID-19 database is a deidentified, nationwide database containing electronic medical record (EMR) data from 87 US-based health systems.\r\n\r\nWe analysed EMR data for 322 482 patients >17 years old with suspected or confirmed SARS-CoV-2 infection who received care between December 2019 and mid-September 2020. Of these, 2750 had T1DM; 57 811 had T2DM; and 261 921 did not have diabetes.\r\n\r\nTTE, defined as presence of a diagnosis code for myocardial infarction, thrombotic stroke, pulmonary embolism, deep vein thrombosis or other TTE.\r\n\r\nOdds of TTE were substantially higher in patients with T1DM (adjusted OR (AOR) 2.23 (1.93-2.59)) and T2DM (AOR 1.52 (1.46-1.58)) versus no diabetes. Among patients with diabetes, odds of TTE were lower in T2DM versus T1DM (AOR 0.84 (0.72-0.98)).\r\n\r\nRisk of TTE during COVID-19 illness is substantially higher in patients with diabetes. Further, risk for TTEs is higher in those with T1DM versus T2DM. Confirmation of increased diabetes-associated clotting risk in future studies may warrant incorporation of diabetes status into SARS-CoV-2 infection treatment algorithms.", "doi": "10.1136/bmjopen-2022-071475", "pmid": "37423628", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10335498"}, {"db": "pii", "key": "bmjopen-2022-071475"}], "notes": [], "created": "2023-10-04T12:07:51.817Z", "modified": "2023-10-04T12:27:06.639Z"}, {"entity": "publication", "iuid": "3b0dc67557c1496d8ba7b7707a7eaab4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b0dc67557c1496d8ba7b7707a7eaab4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b0dc67557c1496d8ba7b7707a7eaab4"}}, "title": "Electronic Tongue for Direct Assessment of SARS-CoV-2-Free and Infected Human Saliva-A Feasibility Study.", "authors": [{"family": "Falk", "given": "Magnus", "initials": "M"}, {"family": "Psotta", "given": "Carolin", "initials": "C"}, {"family": "Cirovic", "given": "Stefan", "initials": "S"}, {"family": "Ohlsson", "given": "Lars", "initials": "L"}, {"family": "Shleev", "given": "Sergey", "initials": "S", "orcid": "0000-0001-6421-2158", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de6b1d4bf8f346d4baae7225d7d44876.json"}}], "type": "journal article", "published": "2023-07-07", "journal": {"title": "Biosensors (Basel)", "issn": "2079-6374", "issn-l": null, "volume": "13", "issue": "7", "pages": null}, "abstract": "An electronic tongue is a powerful analytical instrument based on an array of non-selective chemical sensors with a partial specificity for data gathering and advanced pattern recognition methods for data analysis. Connecting electronic tongues with electrochemical techniques for data collection has led to various applications, mostly within sensing for food quality and environmental monitoring, but also in biomedical research for the analyses of different bioanalytes in human physiological fluids. In this paper, an electronic tongue consisting of six electrodes (viz., gold, platinum, palladium, titanium, iridium, and glassy carbon) was designed and tested in authentic (undiluted, unpretreated) human saliva samples from eight volunteers, collected before and during the COVID-19 pandemic. Investigations of 11 samples using differential pulse voltammetry and a principal component analysis allowed us to distinguish between SARS-CoV-2-free and infected authentic human saliva. This work, as a proof-of-principle demonstration, provides a new perspective for the use of electronic tongues in the field of enzyme-free electrochemical biosensing, highlighting their potential for future applications in non-invasive biomedical analyses.", "doi": "10.3390/bios13070717", "pmid": "37504115", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10377364"}, {"db": "pii", "key": "bios13070717"}], "notes": [], "created": "2023-10-04T12:08:28.764Z", "modified": "2023-10-04T12:36:09.449Z"}, {"entity": "publication", "iuid": "f1a822b3d12043ea9b8edf0c56c1d403", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1a822b3d12043ea9b8edf0c56c1d403.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1a822b3d12043ea9b8edf0c56c1d403"}}, "title": "Characterising information loss due to aggregating epidemic model outputs", "authors": [{"family": "Sherratt", "given": "Katharine", "initials": "K", "orcid": "0000-0003-2049-3423", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2318c0e1d33c49bc8315d0b179581b11.json"}}, {"family": "Srivastava", "given": "Ajitesh", "initials": "A"}, {"family": "Ainslie", "given": "Kylie", "initials": "K", "orcid": "0000-0001-5419-7206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d900ed1096f431dbe5a2890503e2ae1.json"}}, {"family": "Singh", "given": "David E", "initials": "DE", "orcid": "0000-0002-8125-0049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f1646cc9a394508ba40e9fe2c2bb75e.json"}}, {"family": "Cublier", "given": "Aymar", "initials": "A"}, {"family": "Marinescu", "given": "Maria Cristina", "initials": "MC", "orcid": "0000-0002-6978-2974", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/afe31d3872854952b2a3f7725a21601b.json"}}, {"family": "Carretero", "given": "Jesus", "initials": "J"}, {"family": "Garcia", "given": "Alberto Cascajo", "initials": "AC", "orcid": "0000-0001-5506-1431", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72d4f2d2fe6c4bf09fd10748c7524706.json"}}, {"family": "Franco", "given": "Nicolas", "initials": "N"}, {"family": "Willem", "given": "Lander", "initials": "L", "orcid": "0000-0002-9210-1196", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/485594f08c334c55bcf8b1159db1befc.json"}}, {"family": "Abrams", "given": "Steven", "initials": "S", "orcid": "0000-0001-7353-9304", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c906aa35960e4612801d310cc7e44780.json"}}, {"family": "Faes", "given": "Christel", "initials": "C", "orcid": "0000-0002-1878-9869", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f126c26524e048eda78269dd8d36f6e9.json"}}, {"family": "Beutels", "given": "Philippe", "initials": "P", "orcid": "0000-0001-5034-3595", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1de885449fe44778dd1839a3737ac97.json"}}, {"family": "Hens", "given": "Niel", "initials": "N", "orcid": "0000-0003-1881-0637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72e67c1e6e6f4d3496183bfcd15c1a18.json"}}, {"family": "M\u00fcller", "given": "Sebastian", "initials": "S"}, {"family": "Charlton", "given": "Billy", "initials": "B", "orcid": "0000-0002-4760-996X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/17046ad3048f43fe9a462a56c9b0ad90.json"}}, {"family": "Ewert", "given": "Ricardo", "initials": "R", "orcid": "0000-0002-6973-3099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a979805944554162b50eb9e860600d56.json"}}, {"family": "Paltra", "given": "Sydney", "initials": "S", "orcid": "0000-0002-4935-8586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/781a2344678d4aed9d4b04b69bec979c.json"}}, {"family": "Rakow", "given": "Christian", "initials": "C", "orcid": "0000-0003-3760-2243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b209fde9192647fe81f8e6a169790bd6.json"}}, {"family": "Rehmann", "given": "Jakob", "initials": "J", "orcid": "0000-0002-1666-6419", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b69a6e1b3534dd3a45d3847e9f1d37b.json"}}, {"family": "Conrad", "given": "Tim", "initials": "T", "orcid": "0000-0002-5590-5726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1512820ad7794988966c276b7270b720.json"}}, {"family": "Sch\u00fctte", "given": "Christof", "initials": "C", "orcid": "0000-0001-5232-2683", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb4b8b18ea234b92b78364166afb1ace.json"}}, {"family": "Nagel", "given": "Kai", "initials": "K", "orcid": "0000-0003-2775-6898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a51017fbe39c432397d0b1dcd9ca69d4.json"}}, {"family": "Grah", "given": "Rok", "initials": "R", "orcid": "0000-0003-2539-3560", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/825d13bbd68a4e3483c5bf5dca6b6233.json"}}, {"family": "Niehus", "given": "Rene", "initials": "R", "orcid": "0000-0002-6751-4124", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92be39b444394d7a82b312737c389cc8.json"}}, {"family": "Prasse", "given": "Bastian", "initials": "B", "orcid": "0000-0002-7935-9109", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/108d55fb4f0b4dbf90a12486fb9fa7bf.json"}}, {"family": "Sandmann", "given": "Frank", "initials": "F", "orcid": "0000-0001-5641-1931", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d25db72e13d48238c49df02d06639b2.json"}}, {"family": "Funk", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-2842-3406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f03dcbc41884648a4eac5892852899a.json"}}], "type": "posted-content", "published": "2023-07-07", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.07.05.23292245", "pmid": null, "labels": {"Type: Preprint": null, "Category: Other": null, "Funder: H2020": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:12:46.584Z", "modified": "2023-10-04T13:35:01.081Z"}, {"entity": "publication", "iuid": "15d790dcf72a433a8f785f425901fed1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15d790dcf72a433a8f785f425901fed1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15d790dcf72a433a8f785f425901fed1"}}, "title": "Characterization of a fieldable process for airborne virus detection", "authors": [{"family": "Du", "given": "Huifeng", "initials": "H", "orcid": "0000-0001-6281-4120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/442acad1a604483aa208a36d5ad7717d.json"}}, {"family": "Bruno", "given": "Simone", "initials": "S", "orcid": "0000-0001-9235-8226", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ab2d583e3cd489888297e07e4d997a0.json"}}, {"family": "Overholt", "given": "Kalon J", "initials": "KJ", "orcid": "0000-0001-9127-9112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7896a963a1da4f259cea799965effb2d.json"}}, {"family": "Palacios", "given": "Sebastian", "initials": "S", "orcid": "0009-0004-5736-147X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b51d649f4924c27b696ae994f76a2ed.json"}}, {"family": "Huang", "given": "Hsin Ho", "initials": "HH"}, {"family": "Barajas", "given": "Carlos", "initials": "C"}, {"family": "Gross", "given": "Ben", "initials": "B"}, {"family": "Lee", "given": "Cindy", "initials": "C"}, {"family": "Evile", "given": "Haley K", "initials": "HK"}, {"family": "de Sousa", "given": "Nuno Rufino", "initials": "NR"}, {"family": "Rothfuchs", "given": "Antonio Gigliotti", "initials": "AG", "orcid": "0000-0001-6001-7240", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00102c49ae2d41828272e850cd551c9f.json"}}, {"family": "Vecchio", "given": "Domitilla Del", "initials": "DD", "orcid": "0000-0001-6472-8576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bad192b794b4e94842be0fbb06788a2.json"}}], "type": "posted-content", "published": "2023-07-06", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.07.03.23292170", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:09:24.813Z", "modified": "2023-10-04T12:52:32.022Z"}, {"entity": "publication", "iuid": "2d28b2c9c308489387829597ab87bf6c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d28b2c9c308489387829597ab87bf6c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d28b2c9c308489387829597ab87bf6c"}}, "title": "Rethinking Immunity: An Ethnography of Risk and Migration in Sweden.", "authors": [{"family": "Mirsalehi", "given": "Talieh", "initials": "T", "orcid": "0000-0003-2864-0280", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d3c5321697fd43039f99d63566bebe47.json"}}], "type": "journal article", "published": "2023-07-04", "journal": {"title": "Med Anthropol", "issn": "1545-5882", "issn-l": null, "volume": "42", "issue": "5", "pages": "493-505"}, "abstract": "I outline the interplay between biological and socio-cultural dimensions of immunity and risk in the context of migration from Afghanistan to Sweden during the COVID-19 pandemic. Documenting my interlocutors' responses to everyday situations, I explore the challenges they face in a new society. Their references to immunity reveal ideas about bodily and biological functions, as well as sociocultural aspects of risk and immunity as fluid concepts. Understanding how different groups manage risk, practice care, and perceive immunity requires attention to the circumstances that surround individual and communal experiences of care practices. I reveal their perceptions, hopes, concerns, and strategies for immunization against the real risks they encounter.", "doi": "10.1080/01459740.2023.2213389", "pmid": "37253110", "labels": {"Category: Social Science & Humanities": null, "Type: Other": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:11:31.458Z", "modified": "2023-10-04T07:14:11.996Z"}, {"entity": "publication", "iuid": "2e07c80ee4504031838349be1d2dd99f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e07c80ee4504031838349be1d2dd99f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e07c80ee4504031838349be1d2dd99f"}}, "title": "Limosilactobacillus reuteri DSM 17938 supplementation and SARS-CoV-2 specific antibody response in healthy adults: a randomized, triple-blinded, placebo-controlled trial.", "authors": [{"family": "Forsg\u00e5rd", "given": "Richard A", "initials": "RA", "orcid": "0000-0002-1905-918X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d1d3d507a034502bec7777d404a9686.json"}}, {"family": "Rode", "given": "Julia", "initials": "J", "orcid": "0000-0001-9402-4756", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77722adb4fff41bebf126c2854614bc8.json"}}, {"family": "Lobenius-Palm\u00e9r", "given": "Karin", "initials": "K", "orcid": "0000-0001-6061-4643", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4cb5a2abe4b5407997d4a2f965091f1b.json"}}, {"family": "Kamm", "given": "Annalena", "initials": "A"}, {"family": "Patil", "given": "Snehal", "initials": "S"}, {"family": "Tacken", "given": "Mirriam G J", "initials": "MGJ"}, {"family": "Lentjes", "given": "Marleen A H", "initials": "MAH", "orcid": "0000-0003-4713-907X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6930e85465646889cd093e3490ed91c.json"}}, {"family": "Axelsson", "given": "Jakob", "initials": "J", "orcid": "0000-0003-4146-8374", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07b58911256b4da4b9fce60d9e364777.json"}}, {"family": "Grompone", "given": "Gianfranco", "initials": "G"}, {"family": "Montgomery", "given": "Scott", "initials": "S"}, {"family": "Brummer", "given": "Robert J", "initials": "RJ", "orcid": "0000-0002-0362-0008", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/320dbc6671aa4870b0e498001e756c01.json"}}], "type": "randomized controlled trial", "published": "2023-07-04", "journal": {"title": "Gut Microbes", "issn": "1949-0984", "issn-l": null, "volume": "15", "issue": "1", "pages": "2229938"}, "abstract": "Studies have shown that probiotics can decrease the symptoms of respiratory tract infections as well as increase antibody responses following certain vaccinations. We examined the effect of probiotic supplementation on anti-SARS-CoV-2 specific antibody responses upon SARS-CoV-2 infection as well as after COVID-19 vaccination. In this randomized, triple-blinded, placebo-controlled intervention study with a parallel design, 159 healthy adults without prior SARS-CoV-2 infection or COVID-19 vaccination and any known risk factors for severe COVID-19 were randomly allocated into two study arms. The active treatment arm consumed a probiotic product containing a minimum of 1 \u00d7 108 colony-forming units of Limosilactobacillus reuteri DSM 17938 + 10 \u03bcg vitamin D3 twice daily for 6 months. The placebo arm consumed identical tablets containing only 10 \u03bcg vitamin D3. Anti-SARS-CoV-2 specific antibodies and virus neutralizing antibody titers were analyzed from blood samples collected at baseline, after 3 months, and after 6 months. Differences in serum antibody titers between the two study arms were tested with independent t-test using log-transformed values. In the intention-to-treat (ITT) analysis, SARS-CoV-2 infected individuals in the active treatment arm (n = 6) tended to have higher serum anti-spike IgG (609 [168-1480] BAU/ml vs 111 [36.1-1210] BAU/ml, p = 0.080) and anti-receptor binding domain (RBD) IgG (928 [212-3449] BAU/ml vs (83.7 [22.8-2094] BAU/ml, p = 0.066) levels than individuals in the placebo arm (n = 6). Considering individuals who were fully vaccinated with mRNA-based COVID-19 vaccines, the active treatment arm (n = 10) exhibited significantly higher serum levels of anti-RBD IgA (135 [32.9-976] BAU/ml vs 61.3 [26.7-97.1] BAU/ml, p = 0.036) than the placebo arm (n = 7) >28 days postvaccination. Supplementation with specific probiotics might improve the long-term efficacy of mRNA-based COVID-19 vaccines via enhanced IgA response.", "doi": "10.1080/19490976.2023.2229938", "pmid": "37401761", "labels": {"Category: Other": null, "Category: Vaccines": null, "Funder: H2020": null}, "xrefs": [{"db": "pmc", "key": "PMC10321188"}], "notes": [], "created": "2023-10-04T12:07:54.497Z", "modified": "2023-10-04T12:28:27.762Z"}, {"entity": "publication", "iuid": "6a8e0b3a19ee4b38b0a41b24e28e3a03", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a8e0b3a19ee4b38b0a41b24e28e3a03.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a8e0b3a19ee4b38b0a41b24e28e3a03"}}, "title": "Policies and resources for strengthening of emergency and critical care services in the context of the global COVID-19 pandemic in Kenya.", "authors": [{"family": "Oliwa", "given": "Jacquie Narotso", "initials": "JN", "orcid": "0000-0002-4575-2447", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9eae04e0d0fe47fc9263e1014a63a88d.json"}}, {"family": "Mazhar", "given": "Rosanna Jeffries", "initials": "RJ", "orcid": "0000-0003-2367-2072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/acca58542d9a49088ecbddbf9e0c4c99.json"}}, {"family": "Serem", "given": "George", "initials": "G"}, {"family": "Khalid", "given": "Karima", "initials": "K"}, {"family": "Amoth", "given": "Patrick", "initials": "P"}, {"family": "Kiarie", "given": "Helen", "initials": "H", "orcid": "0000-0003-2048-8173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b6b816132dba47889ba7e551e83d4fcf.json"}}, {"family": "Warfa", "given": "Osman", "initials": "O"}, {"family": "Schell", "given": "Carl Otto", "initials": "CO", "orcid": "0000-0002-7904-1336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a40b337b45b471d97a102c355c9d874.json"}}, {"family": "Baker", "given": "Tim", "initials": "T", "orcid": "0000-0001-8727-7018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1454fc20049b4d47865268adf16d104a.json"}}, {"family": "English", "given": "Mike", "initials": "M", "orcid": "0000-0002-7427-0826", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d680cdafc8854a619f1919652dd16aed.json"}}, {"family": "Mcknight", "given": "Jacob", "initials": "J"}], "type": "journal article", "published": "2023-07-03", "journal": {"title": "PLOS Glob Public Health", "issn": "2767-3375", "issn-l": null, "volume": "3", "issue": "7", "pages": "e0000483"}, "abstract": "Critical illnesses cause several million deaths annually, with many of these occurring in low-resource settings like Kenya. Great efforts have been made worldwide to scale up critical care to reduce deaths from COVID-19. Lower income countries with fragile health systems may not have had sufficient resources to upscale their critical care. We aimed to review how efforts to strengthen emergency and critical care were operationalised during the pandemic in Kenya to point towards how future emergencies should be approached. This was an exploratory study that involved document reviews, and discussions with key stakeholders (donors, international agencies, professional associations, government actors), during the first year of the pandemic in Kenya. Our findings suggest that pre-pandemic health services for the critically ill in Kenya were sparse and unable to meet rising demand, with major limitations noted in human resources and infrastructure. The pandemic response saw galvanised action by the Government of Kenya and other agencies to mobilise resources (approximately USD 218 million). Earlier efforts were largely directed towards advanced critical care but since the human resource gap could not be reduced immediately, a lot of equipment remained unused. We also note that despite strong policies on what resources should be available, the reality on the ground was that there were often critical shortages. While emergency response mechanisms are not conducive to addressing long-term health system issues, the pandemic increased global recognition of the need to fund care for the critically ill. Limited resources may be best prioritised towards a public health approach with focus on provision of relatively basic, lower cost essential emergency and critical care (EECC) that can potentially save the most lives amongst critically ill patients.", "doi": "10.1371/journal.pgph.0000483", "pmid": "37399177", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10317215"}, {"db": "pii", "key": "PGPH-D-22-00633"}], "notes": [], "created": "2023-10-04T12:10:47.776Z", "modified": "2023-10-04T13:31:35.356Z"}, {"entity": "publication", "iuid": "ad853f575d43489183421c0102c22497", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ad853f575d43489183421c0102c22497.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ad853f575d43489183421c0102c22497"}}, "title": "Relationship between People's Interest in Medication Adherence, Health Literacy, and Self-Care: An Infodemiological Analysis in the Pre- and Post-COVID-19 Era.", "authors": [{"family": "Grandieri", "given": "Andrea", "initials": "A", "orcid": "0000-0003-0553-5971", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e8a8fbb98fa4b2fbbb37e729c9276aa.json"}}, {"family": "Trevisan", "given": "Caterina", "initials": "C"}, {"family": "Gentili", "given": "Susanna", "initials": "S"}, {"family": "Vetrano", "given": "Davide Liborio", "initials": "DL", "orcid": "0000-0002-3099-4830", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0124721bb214413a34c965b6accc64b.json"}}, {"family": "Liotta", "given": "Giuseppe", "initials": "G"}, {"family": "Volpato", "given": "Stefano", "initials": "S"}], "type": "journal article", "published": "2023-07-01", "journal": {"title": "J Pers Med", "issn": "2075-4426", "issn-l": null, "volume": "13", "issue": "7", "pages": null}, "abstract": "The prevalence of non-communicable diseases has risen sharply in recent years, particularly among older individuals who require complex drug regimens. Patients are increasingly required to manage their health through medication adherence and self-care, but about 50% of patients struggle to adhere to prescribed treatments. This study explored the relationship between interest in medication adherence, health literacy, and self-care and how it changed during the COVID-19 pandemic. We used Google Trends to measure relative search volumes (RSVs) for these three topics from 2012 to 2022. We found that interest in self-care increased the most over time, followed by health literacy and medication adherence. Direct correlations emerged between RSVs for medication adherence and health literacy (r = 0.674, p < 0.0001), medication adherence and self-care (r = 0.466, p < 0.0001), and health literacy and self-care (r = 0.545, p < 0.0001). After the COVID-19 pandemic outbreak, interest in self-care significantly increased, and Latin countries showed a greater interest in self-care than other geographical areas. This study suggests that people are increasingly interested in managing their health, especially in the context of the recent pandemic, and that infodemiology may provide interesting information about the attitudes of the population toward chronic disease management.", "doi": "10.3390/jpm13071090", "pmid": "37511703", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10381156"}, {"db": "pii", "key": "jpm13071090"}], "notes": [], "created": "2023-10-04T12:09:58.719Z", "modified": "2023-10-04T13:06:56.219Z"}, {"entity": "publication", "iuid": "f8e34c2bbc934c90b3e24f59dbffe111", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f8e34c2bbc934c90b3e24f59dbffe111.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f8e34c2bbc934c90b3e24f59dbffe111"}}, "title": "Preclinical and Human Phase 1 Studies of Aerosolized Hydroxychloroquine: Implications for Antiviral COVID-19 Therapy", "authors": [{"family": "Bentur", "given": "Ohad S", "initials": "OS", "orcid": "0000-0002-5976-7121", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30bdc9224fad462196908646f277a76f.json"}}, {"family": "Hutt", "given": "Richard", "initials": "R"}, {"family": "Brassil", "given": "Donna", "initials": "D"}, {"family": "Kriegegr", "given": "Ana C", "initials": "AC"}, {"family": "B\u00e4ckman", "given": "Per", "initials": "P"}, {"family": "Charous", "given": "B Lauren", "initials": "BL"}, {"family": "Boushey", "given": "Homer", "initials": "H", "orcid": "0000-0002-4373-9265", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e67d654785c2406fb0ce1ba5f3d384a3.json"}}, {"family": "Gonda", "given": "Igor", "initials": "I"}, {"family": "Coller", "given": "Barry S", "initials": "BS", "orcid": "0000-0002-9078-7155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/648db6fb396f49938d98dcdc82b63658.json"}}, {"family": "MacArthur", "given": "Robert B", "initials": "RB", "orcid": "0000-0002-3264-4666", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a38b7120c21a4985be747fc84e7d9bd0.json"}}], "type": "posted-content", "published": "2023-07-01", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.06.22.23291702", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:07:45.920Z", "modified": "2023-10-04T12:24:46.443Z"}, {"entity": "publication", "iuid": "2090449e3a554ddc86000f62047f458c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2090449e3a554ddc86000f62047f458c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2090449e3a554ddc86000f62047f458c"}}, "title": "Use of the neutrophil-to-lymphocyte ratio and an oxygen requirement to predict disease severity in patients with COVID-19.", "authors": [{"family": "Ozawa", "given": "Takuya", "initials": "T"}, {"family": "Asakura", "given": "Takanori", "initials": "T"}, {"family": "Chubachi", "given": "Shotaro", "initials": "S"}, {"family": "Namkoong", "given": "Ho", "initials": "H"}, {"family": "Tanaka", "given": "Hiromu", "initials": "H"}, {"family": "Lee", "given": "Ko", "initials": "K"}, {"family": "Fukushima", "given": "Takahiro", "initials": "T"}, {"family": "Otake", "given": "Shiro", "initials": "S"}, {"family": "Nakagawara", "given": "Kensuke", "initials": "K"}, {"family": "Watase", "given": "Mayuko", "initials": "M"}, {"family": "Masaki", "given": "Katsunori", "initials": "K"}, {"family": "Kamata", "given": "Hirofumi", "initials": "H"}, {"family": "Ishii", "given": "Makoto", "initials": "M"}, {"family": "Hasegawa", "given": "Naoki", "initials": "N"}, {"family": "Harada", "given": "Norihiro", "initials": "N"}, {"family": "Ueda", "given": "Tetsuya", "initials": "T"}, {"family": "Ueda", "given": "Soichiro", "initials": "S"}, {"family": "Ishiguro", "given": "Takashi", "initials": "T"}, {"family": "Arimura", "given": "Ken", "initials": "K"}, {"family": "Saito", "given": "Fukuki", "initials": "F"}, {"family": "Yoshiyama", "given": "Takashi", "initials": "T"}, {"family": "Nakano", "given": "Yasushi", "initials": "Y"}, {"family": "Mutoh", "given": "Yoshikazu", "initials": "Y"}, {"family": "Suzuki", "given": "Yusuke", "initials": "Y"}, {"family": "Edahiro", "given": "Ryuya", "initials": "R"}, {"family": "Murakami", "given": "Koji", "initials": "K"}, {"family": "Okada", "given": "Yukinori", "initials": "Y"}, {"family": "Koike", "given": "Ryuji", "initials": "R"}, {"family": "Kitagawa", "given": "Yuko", "initials": "Y"}, {"family": "Tokunaga", "given": "Katsushi", "initials": "K"}, {"family": "Kimura", "given": "Akinori", "initials": "A"}, {"family": "Imoto", "given": "Seiya", "initials": "S"}, {"family": "Miyano", "given": "Satoru", "initials": "S"}, {"family": "Ogawa", "given": "Seishi", "initials": "S"}, {"family": "Kanai", "given": "Takanori", "initials": "T"}, {"family": "Fukunaga", "given": "Koichi", "initials": "K"}, {"family": "Japan COVID-19 Task Force", "given": "", "initials": ""}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Respir Investig", "issn": "2212-5353", "issn-l": null, "volume": "61", "issue": "4", "pages": "454-459"}, "abstract": "We investigated the association between complete blood count, including neutrophil-to-lymphocyte ratio (NLR) in combination with patient characteristics, and coronavirus disease (COVID-19) outcomes to identify the best prognostic indicator. We analyzed data of patients with confirmed COVID-19 from the nationwide database of the Japan COVID-19 Task Force between February 2020 and November 2021. A composite outcome was defined as the most severe condition, including noninvasive positive-pressure ventilation, high-flow nasal cannula, invasive mechanical ventilation, extracorporeal membrane oxygenation, or death. Of 2425 patients in the analysis, 472 (19.5%) experienced a composite outcome. NLR was the best predictor of composite outcomes, with an area under the curve (AUC) of 0.81, and a sensitivity and specificity of 72.3% and 75.7%, respectively, using a cut-off value of 5.04. The combination of NLR and an oxygen requirement on admission had the highest AUC (0.88). This simple combination may help identify patients at risk of progression to severe disease.", "doi": "10.1016/j.resinv.2023.03.007", "pmid": "37121116", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Category: Serology": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10113601"}, {"db": "pii", "key": "S2212-5345(23)00037-0"}], "notes": [], "created": "2023-10-04T05:11:33.967Z", "modified": "2023-10-04T07:15:20.168Z"}, {"entity": "publication", "iuid": "bede0574495043b5a03b3f9b2178cfea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bede0574495043b5a03b3f9b2178cfea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bede0574495043b5a03b3f9b2178cfea"}}, "title": "The association between leisure engagement and loneliness before and during the COVID-19 pandemic: A Nordic population-based study.", "authors": [{"family": "Nyqvist", "given": "Fredrica", "initials": "F", "orcid": "0000-0001-6554-8040", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc9027ea4dc241a18acd24a108cf33ce.json"}}, {"family": "Nilsson", "given": "Ingeborg", "initials": "I"}, {"family": "N\u00e4sman", "given": "Marina", "initials": "M"}, {"family": "Olofsson", "given": "Birgitta", "initials": "B"}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": "51", "issue": "5", "pages": "744-753"}, "abstract": "The main aim of this study was to examine leisure engagement and loneliness among older adults before and during the COVID-19 pandemic by analysing population-based data from western Finland and northern Sweden.\r\n\r\nThe data originated from the Gerontological Regional Database (GERDA) postal questionnaire study conducted in 2016 (n=7996) and 2021 (n=8148) among older adults aged 65, 70, 75, 80 and 85 years. Associations between loneliness and leisure engagement were analysed using logistic regression.\r\n\r\nIn total, 10% and 9% of the older adults reported loneliness in 2016 and 2021, respectively. The results showed that a lack of engagement in socialising and pleasure was independently associated with loneliness in both study years, while a lack of engagement in cultural activities was associated with loneliness in 2016 only. In 2021, the likelihood of experiencing loneliness was higher in the Finnish region than in the Swedish region. In addition, those reporting a decrease in hobby and socialising leisure activities due to the COVID-19 pandemic were more likely to report loneliness.\r\n\r\nMost leisure activities decreased during the pandemic, suggesting an increase in social isolation. However, this did not reflect an increase in loneliness in the studied regions. The evidence suggests that leisure engagement, especially socialising activities, continued to be important for well-being among older adults during the pandemic. Further, loneliness was affected by contextual factors as well as individual-level characteristics. Thus, according to the measures reported here, the pandemic seemed to have a slightly weakened well-being impact in Finland.", "doi": "10.1177/14034948231171964", "pmid": "37165572", "labels": {"Category: Social Science & Humanities": null, "Funder: VR": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10183342"}], "notes": [], "created": "2023-10-04T05:11:21.823Z", "modified": "2023-10-04T07:10:17.734Z"}, {"entity": "publication", "iuid": "770c1621ca0a42a8a46ddebe70cb92e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/770c1621ca0a42a8a46ddebe70cb92e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/770c1621ca0a42a8a46ddebe70cb92e1"}}, "title": "Taking Risks to Protect Others-Pediatric Vaccination and Moral Responsibility.", "authors": [{"family": "Nihl\u00e9n Fahlquist", "given": "Jessica", "initials": "J", "orcid": "0000-0001-9683-7005", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/927d3a3a934a45dca7f88072507aa153.json"}}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Public Health Ethics", "issn": "1754-9973", "issn-l": null, "volume": "16", "issue": "2", "pages": "127-138"}, "abstract": "The COVID-19 pandemic during 2020-2022 raised ethical questions concerning the balance between individual autonomy and the protection of the population, vulnerable individuals and the healthcare system. Pediatric COVID-19 vaccination differs from, for example, measles vaccination in that children were not as severely affected. The main question concerning pediatric vaccination has been whether the autonomy of parents outweighs the protection of the population. When children are seen as mature enough to be granted autonomy, questions arise about whether they have the right to decline vaccination and who should make the decision when parents disagree with each other and/or the child. In this paper, I argue that children should be encouraged to not only take responsibility for themselves, but for others. The discussion of pediatric vaccination in cases where this kind of risk-benefit ratio exists extends beyond the 2020-2022 pandemic. The pandemic entailed a question that is crucial for the future of public health as a global problem, that is, to what extent children should be seen as responsible decision-makers who are capable of contributing to its management and potential solution. I conclude that society should encourage children to cultivate such responsibility, conceived as a virtue, in the context of public health.", "doi": "10.1093/phe/phad005", "pmid": "37547911", "labels": {"Category: Public Health": null, "Type: Other": null, "Category: Vaccines": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10401494"}, {"db": "pii", "key": "phad005"}], "notes": [], "created": "2023-10-05T08:26:21.511Z", "modified": "2023-10-06T04:56:09.662Z"}, {"entity": "publication", "iuid": "07fa0b12e97341debcc3e6aab2a33c15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07fa0b12e97341debcc3e6aab2a33c15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07fa0b12e97341debcc3e6aab2a33c15"}}, "title": "Prognostic potential of creatinine and Cystatin C in COVID-19 - a retrospective cohort study from Karolinska University Hospital.", "authors": [{"family": "Sj\u00f6str\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Markgren", "given": "Per Olof", "initials": "PO"}, {"family": "Hansson", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Scand J Clin Lab Invest", "issn": "1502-7686", "issn-l": null, "volume": "83", "issue": "4", "pages": "251-257"}, "abstract": "Acute kidney injury (AKI) is common in COVID-19 and is diagnosed using relative serum creatinine increase. Estimated GFR (eGFR) is a more accurate measure of glomerular filtration due to compensation for age and sex. Serum Cystatin-C, less affected by non-renal factors than creatinine, may further improve renal function estimation and add prognostic information. Our aim is to investigate the importance of a calculated eGFR in relation to creatinine as well as the value of Cystatin-C in patients with severe COVID-19. This study is a retrospective cohort study investigating levels and trends of routine laboratory parameters combined with clinical data from 286 consecutive patients with severe COVID-19 from Karolinska University Hospital. AKI developed in 38% of the patients and 15% were treated with hemodialysis. Mortality in the AKI group was 42% compared to 5% in the non-AKI group. At admission, eGFR, but not creatinine, was significantly associated with AKI development, need of intubation and mortality. Moreover, discrepant results between eGFR creatinine (eGFRCR) and eGFR Cystatin-C (eGFRCYS) was common in the ICU patients compared to non-ICU patients and related to outcome. In addition, we found that daily median Cystatin-C levels during the hospital stay were correlated to neutrophil count. eGFRCR was found to be an overall better prognostic marker than creatinine regarding AKI development and prognosis in severe COVID-19. Fulfillment of Shrunken pore syndrome criteria indicated a higher mortality risk. Cystatin-C may be related to neutrophil count, which could be a clue to the discrepant eGFR results.", "doi": "10.1080/00365513.2023.2210291", "pmid": "37167478", "labels": {"Category: Proteins": null, "Category: Serology": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:10:12.197Z", "modified": "2023-10-04T06:28:40.854Z"}, {"entity": "publication", "iuid": "6acd649d6131409fba5f319ad7ac1f48", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6acd649d6131409fba5f319ad7ac1f48.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6acd649d6131409fba5f319ad7ac1f48"}}, "title": "Prognostic performance of blood neurofilament light chain protein in hospitalized COVID-19 patients without major central nervous system manifestations: an individual participant data meta-analysis.", "authors": [{"family": "Abdelhak", "given": "Ahmed", "initials": "A", "orcid": "0000-0001-9731-4169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2c3007e2b3e4af0855c4f64b89a1f69.json"}}, {"family": "Barba", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-4237-6850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0cec76ce00c94352aac33ccbf3a5028d.json"}}, {"family": "Romoli", "given": "Michele", "initials": "M", "orcid": "0000-0001-8009-8543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/954e16c7c9934d23b7b8a489adccf2d4.json"}}, {"family": "Benkert", "given": "Pascal", "initials": "P", "orcid": "0000-0001-6525-8174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a8e93f751ae40cbadbd19d8840639fe.json"}}, {"family": "Conversi", "given": "Francesco", "initials": "F"}, {"family": "D'Anna", "given": "Lucio", "initials": "L", "orcid": "0000-0002-6794-3850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1601767932dc4a4d9a8d0b5113763600.json"}}, {"family": "Masvekar", "given": "Ruturaj R", "initials": "RR", "orcid": "0000-0002-4570-4533", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25270f2a54cf416b9dde587dab0ade04.json"}}, {"family": "Bielekova", "given": "Bibiana", "initials": "B", "orcid": "0000-0002-0959-9430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b2a7812ae084c4b8b8f69168032e0b1.json"}}, {"family": "Prudencio", "given": "Mercedes", "initials": "M", "orcid": "0000-0002-4894-4858", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6206178f7b0448ffb963acacf6e37023.json"}}, {"family": "Petrucelli", "given": "Leonard", "initials": "L", "orcid": "0000-0003-2959-129X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46d6fe83e1494ae6be0214bd3b41e4ef.json"}}, {"family": "Meschia", "given": "James F", "initials": "JF", "orcid": "0000-0002-4475-8142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/590bd75802c640a0949896e6aa8befc8.json"}}, {"family": "Erben", "given": "Young", "initials": "Y", "orcid": "0000-0002-1571-6955", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b026b60bc68648579b7e0370ff00c0fe.json"}}, {"family": "Furlan", "given": "Roberto", "initials": "R", "orcid": "0000-0001-7376-9425", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/940db6ecfcbd4383a1369393fa8e206e.json"}}, {"family": "De Lorenzo", "given": "Rebecca", "initials": "R", "orcid": "0000-0002-1281-7996", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1eddd82f29f64c889211037bb64cf707.json"}}, {"family": "Mandelli", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-6494-7776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4d010bf83e14566bceae44bcd63d36c.json"}}, {"family": "Sutter", "given": "Raoul", "initials": "R", "orcid": "0000-0002-6575-356X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0a395e40bd6464084ec2cddd90f2295.json"}}, {"family": "Hert", "given": "Lisa", "initials": "L"}, {"family": "Epple", "given": "Varenka", "initials": "V", "orcid": "0000-0002-8736-0070", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7773c7cf8f4541019af057e2bbbdeefa.json"}}, {"family": "Marastoni", "given": "Damiano", "initials": "D", "orcid": "0000-0003-0358-9431", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af2ff46eb01a473aa077029d582903b2.json"}}, {"family": "Sellner", "given": "Johann", "initials": "J", "orcid": "0000-0001-8749-5533", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/38b82ef4d31a4939be4e1024faa664bb.json"}}, {"family": "Steinacker", "given": "Petra", "initials": "P"}, {"family": "Aamodt", "given": "Anne Hege", "initials": "AH", "orcid": "0000-0002-2824-2760", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b21211bae394fef867be93f162d8ef8.json"}}, {"family": "Heggelund", "given": "Lars", "initials": "L", "orcid": "0000-0002-1669-1032", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9befa124c647487d803e8dba68495821.json"}}, {"family": "Dyrhol-Riise", "given": "Anne Margarita", "initials": "AM", "orcid": "0000-0003-4009-4032", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/051b91855a064394a525b898992aa834.json"}}, {"family": "Virhammar", "given": "Johan", "initials": "J", "orcid": "0000-0001-9901-2949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9db4ac69a3e8495ea8e71ae60042fa5c.json"}}, {"family": "F\u00e4llmar", "given": "David", "initials": "D", "orcid": "0000-0001-5615-2036", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08e1206ab94a43788a7fc641ee13407c.json"}}, {"family": "Rostami", "given": "Elham", "initials": "E", "orcid": "0000-0003-1218-6247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c95efe7a4cc4fcfa73fac8b49641ca1.json"}}, {"family": "Kumlien", "given": "Eva", "initials": "E", "orcid": "0000-0002-1952-8791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de1d39588b21438fabae7d27acf4b237.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/351fab09f6e24b9f9e6695da83947cb6.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e314740b02c344d2b336a9410e28041e.json"}}, {"family": "Tumani", "given": "Hayrettin", "initials": "H", "orcid": "0000-0002-1647-6201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c76797ddf9d4909a1c5f2140ec3531e.json"}}, {"family": "Sacco", "given": "Simona", "initials": "S", "orcid": "0000-0003-0651-1939", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0447acf2277a43049232a0ad7614d310.json"}}, {"family": "Green", "given": "Ari J", "initials": "AJ", "orcid": "0000-0001-9275-3066", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/829f4905eef64f6b980141ae7b2e6f9b.json"}}, {"family": "Otto", "given": "Markus", "initials": "M", "orcid": "0000-0003-4273-4267", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e472a52c9d04a9fa4161d80fa0c6bdb.json"}}, {"family": "Kuhle", "given": "Jens", "initials": "J", "orcid": "0000-0002-6963-8892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/187936aaf8c342e58dec7adc5b23ad91.json"}}, {"family": "Ornello", "given": "Raffaele", "initials": "R", "orcid": "0000-0001-9501-4031", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/133160eee8a942dd9f7d6cad321520c6.json"}}, {"family": "Foschi", "given": "Matteo", "initials": "M", "orcid": "0000-0002-0321-7155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc49b113289e4deabff8a47fdf0bea6d.json"}}, {"family": "Abu-Rumeileh", "given": "Samir", "initials": "S", "orcid": "0000-0003-0631-8506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8531166b14e04d998571b80fb0e761ff.json"}}], "type": "meta-analysis", "published": "2023-07-00", "journal": {"title": "J Neurol", "issn": "1432-1459", "issn-l": null, "volume": "270", "issue": "7", "pages": "3315-3328"}, "abstract": "To investigate the prognostic value of blood neurofilament light chain protein (NfL) levels in the acute phase of coronavirus disease 2019 (COVID-19).\r\n\r\nWe conducted an individual participant data (IPD) meta-analysis after screening on MEDLINE and Scopus to May 23rd 2022. We included studies with hospitalized adult COVID-19 patients without major COVID-19-associated central nervous system (CNS) manifestations and with a measurement of blood NfL in the acute phase as well as data regarding at least one clinical outcome including intensive care unit (ICU) admission, need of mechanical ventilation (MV) and death. We derived the age-adjusted measures NfL Z scores and conducted mixed-effects modelling to test associations between NfL Z scores and other variables, encompassing clinical outcomes. Summary receiver operating characteristic curves (SROCs) were used to calculate the area under the curve (AUC) for blood NfL.\r\n\r\nWe identified 382 records, of which 7 studies were included with a total of 669 hospitalized COVID-19 cases (mean age 66.2 \u00b1 15.0 years, 68.1% males). Median NfL Z score at admission was elevated compared to the age-corrected reference population (2.37, IQR: 1.13-3.06, referring to 99th percentile in healthy controls). NfL Z scores were significantly associated with disease duration and severity. Higher NfL Z scores were associated with a higher likelihood of ICU admission, need of MV, and death. SROCs revealed AUCs of 0.74, 0.80 and 0.71 for mortality, need of MV and ICU admission, respectively.\r\n\r\nBlood NfL levels were elevated in the acute phase of COVID-19 patients without major CNS manifestations and associated with clinical severity and poor outcome. The marker might ameliorate the performance of prognostic multivariable algorithms in COVID-19.", "doi": "10.1007/s00415-023-11768-1", "pmid": "37184659", "labels": {"Category: Health": null, "Category: Proteins": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10183689"}, {"db": "pii", "key": "10.1007/s00415-023-11768-1"}], "notes": [], "created": "2023-10-04T05:10:19.728Z", "modified": "2023-10-04T06:35:13.442Z"}, {"entity": "publication", "iuid": "25d376987001470aa29efeaa325aa75e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/25d376987001470aa29efeaa325aa75e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/25d376987001470aa29efeaa325aa75e"}}, "title": "New evidence of gender inequality during COVID-19 outbreak in the Middle East and North Africa.", "authors": [{"family": "Abdel-Rahman", "given": "Suzan", "initials": "S"}, {"family": "Awwad", "given": "Fuad A", "initials": "FA"}, {"family": "Qasim", "given": "Muhammad", "initials": "M"}, {"family": "Abonazel", "given": "Mohamed R", "initials": "MR"}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "issn-l": null, "volume": "9", "issue": "7", "pages": "e17705"}, "abstract": "The COVID-19 pandemic has significantly altered employment and income distribution, impacting women and men differently. This study investigates the negative effects of COVID-19 on the labour market, focusing on the gender gap in five countries in the Middle East and North Africa (MENA) region. The study indicates whether women are more susceptible to losing their jobs, either temporarily or permanently, switching their primary occupation, and experiencing decreased working hours and income compared to men during the COVID-19 outbreak. The study utilizes a multivariate Probit model to estimate the relationship between gender and adverse labour outcomes controlling for correlations among outcomes. Data are obtained from the Combined COVID-19 MENA Monitor Household Survey, covering Egypt, Tunisia, Morocco, Jordan, and Sudan. The findings of this study offer empirical evidence of the gender gap in labour market outcomes during the pandemic. Women are more likely than men to experience negative work outcomes, such as permanent job loss and change in their main job. The increased childcare and housework responsibilities have significantly impacted women's labour market outcomes during the pandemic. However, the availability of telework has reduced the likelihood of job loss among women. The study's results contribute to a better understanding of the impact of COVID-19 on gender inequality in understudied MENA countries. Mitigation policies should focus on supporting vulnerable women who have experienced disproportionate negative effects of COVID-19.", "doi": "10.1016/j.heliyon.2023.e17705", "pmid": "37456038", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10338972"}, {"db": "pii", "key": "S2405-8440(23)04913-7"}], "notes": [], "created": "2023-10-04T12:09:05.868Z", "modified": "2023-10-04T12:49:06.026Z"}, {"entity": "publication", "iuid": "c2ca3f8574624b31bb877b6129945208", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2ca3f8574624b31bb877b6129945208.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2ca3f8574624b31bb877b6129945208"}}, "title": "Mucosal immune responses following a fourth SARS-CoV-2 vaccine dose.", "authors": [{"family": "Bladh", "given": "Oscar", "initials": "O"}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Norin", "given": "Nina Greilert", "initials": "NG"}, {"family": "Aguilera", "given": "Katherina", "initials": "K"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "letter", "published": "2023-07-00", "journal": {"title": "The Lancet Microbe", "issn": "2666-5247", "volume": "4", "issue": "7", "pages": "e488", "issn-l": "2666-5247"}, "abstract": null, "doi": "10.1016/S2666-5247(23)00102-7", "pmid": "37086736", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pmc", "key": "PMC10115585"}, {"db": "pii", "key": "S2666-5247(23)00102-7"}], "notes": [], "created": "2023-07-13T11:38:02.948Z", "modified": "2023-07-13T11:38:42.510Z"}, {"entity": "publication", "iuid": "c1ef68d3ddce4d4ea525ceeccd27a474", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1ef68d3ddce4d4ea525ceeccd27a474.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1ef68d3ddce4d4ea525ceeccd27a474"}}, "title": "Impact of the COVID-19 pandemic on Swedish adults aged 77 years and older: Age differences in lifestyle changes.", "authors": [{"family": "Augustsson", "given": "Erika", "initials": "E", "orcid": "0000-0001-9958-4090", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0cd1d8d125cc426e9c0d9c587fbc9513.json"}}, {"family": "Von Saenger", "given": "Isabelle", "initials": "I"}, {"family": "Agahi", "given": "Neda", "initials": "N"}, {"family": "K\u00e5reholt", "given": "Ingemar", "initials": "I"}, {"family": "Ericsson", "given": "Malin", "initials": "M"}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": "51", "issue": "5", "pages": "764-768"}, "abstract": "This study aimed to describe the impact of the COVID-19 pandemic on lifestyle and social activities among older adults in Sweden, with a special focus on differences between the 'younger old' (aged 77-84) and 'older old' (aged 85-109).\r\n\r\nThis study is based on a nationally representative sample of older adults (aged \u2a7e77 years) in Sweden (SWEOLD). Data were collected between May 2021 and April 2022, when many recommendations were removed but the virus was still classified as a public health disease. We studied occurrences and differences between the two age groups in several lifestyle factors and social activities.\r\n\r\nThe younger old displayed larger changes in lifestyles because of the pandemic than the older old. Most changes were found in social interactions with family.\r\n\r\nOur results highlight the large heterogeneity within the Swedish population aged \u2a7e77 years, and that the younger old experienced a bigger lifestyle change than the older old. Previous activity levels might be important to consider in order to understand how regulations may affect the older population. Finally, our findings indicate large age differences in Internet use, which require attention to prevent digital exclusion of an already vulnerable group.", "doi": "10.1177/14034948231172249", "pmid": "37151122", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10170261"}], "notes": [], "created": "2023-10-04T05:12:01.762Z", "modified": "2023-10-04T07:26:10.285Z"}, {"entity": "publication", "iuid": "41d8faa1aee942a1b8f3986561852142", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41d8faa1aee942a1b8f3986561852142.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41d8faa1aee942a1b8f3986561852142"}}, "title": "ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies.", "authors": [{"family": "Grasselli", "given": "Giacomo", "initials": "G", "orcid": "0000-0002-1735-1400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a68eafa11dae413bb14842cfb8647144.json"}}, {"family": "Calfee", "given": "Carolyn S", "initials": "CS"}, {"family": "Camporota", "given": "Luigi", "initials": "L"}, {"family": "Poole", "given": "Daniele", "initials": "D"}, {"family": "Amato", "given": "Marcelo B P", "initials": "MBP"}, {"family": "Antonelli", "given": "Massimo", "initials": "M"}, {"family": "Arabi", "given": "Yaseen M", "initials": "YM"}, {"family": "Baroncelli", "given": "Francesca", "initials": "F"}, {"family": "Beitler", "given": "Jeremy R", "initials": "JR"}, {"family": "Bellani", "given": "Giacomo", "initials": "G"}, {"family": "Bellingan", "given": "Geoff", "initials": "G"}, {"family": "Blackwood", "given": "Bronagh", "initials": "B"}, {"family": "Bos", "given": "Lieuwe D J", "initials": "LDJ"}, {"family": "Brochard", "given": "Laurent", "initials": "L"}, {"family": "Brodie", "given": "Daniel", "initials": "D"}, {"family": "Burns", "given": "Karen E A", "initials": "KEA"}, {"family": "Combes", "given": "Alain", "initials": "A"}, {"family": "D'Arrigo", "given": "Sonia", "initials": "S"}, {"family": "De Backer", "given": "Daniel", "initials": "D"}, {"family": "Demoule", "given": "Alexandre", "initials": "A"}, {"family": "Einav", "given": "Sharon", "initials": "S"}, {"family": "Fan", "given": "Eddy", "initials": "E"}, {"family": "Ferguson", "given": "Niall D", "initials": "ND"}, {"family": "Frat", "given": "Jean-Pierre", "initials": "J"}, {"family": "Gattinoni", "given": "Luciano", "initials": "L"}, {"family": "Gu\u00e9rin", "given": "Claude", "initials": "C"}, {"family": "Herridge", "given": "Margaret S", "initials": "MS"}, {"family": "Hodgson", "given": "Carol", "initials": "C"}, {"family": "Hough", "given": "Catherine L", "initials": "CL"}, {"family": "Jaber", "given": "Samir", "initials": "S"}, {"family": "Juffermans", "given": "Nicole P", "initials": "NP"}, {"family": "Karagiannidis", "given": "Christian", "initials": "C"}, {"family": "Kesecioglu", "given": "Jozef", "initials": "J"}, {"family": "Kwizera", "given": "Arthur", "initials": "A"}, {"family": "Laffey", "given": "John G", "initials": "JG"}, {"family": "Mancebo", "given": "Jordi", "initials": "J"}, {"family": "Matthay", "given": "Michael A", "initials": "MA"}, {"family": "McAuley", "given": "Daniel F", "initials": "DF"}, {"family": "Mercat", "given": "Alain", "initials": "A"}, {"family": "Meyer", "given": "Nuala J", "initials": "NJ"}, {"family": "Moss", "given": "Marc", "initials": "M"}, {"family": "Munshi", "given": "Laveena", "initials": "L"}, {"family": "Myatra", "given": "Sheila N", "initials": "SN"}, {"family": "Ng Gong", "given": "Michelle", "initials": "M"}, {"family": "Papazian", "given": "Laurent", "initials": "L"}, {"family": "Patel", "given": "Bhakti K", "initials": "BK"}, {"family": "Pellegrini", "given": "Mariangela", "initials": "M"}, {"family": "Perner", "given": "Anders", "initials": "A"}, {"family": "Pesenti", "given": "Antonio", "initials": "A"}, {"family": "Piquilloud", "given": "Lise", "initials": "L"}, {"family": "Qiu", "given": "Haibo", "initials": "H"}, {"family": "Ranieri", "given": "Marco V", "initials": "MV"}, {"family": "Riviello", "given": "Elisabeth", "initials": "E"}, {"family": "Slutsky", "given": "Arthur S", "initials": "AS"}, {"family": "Stapleton", "given": "Renee D", "initials": "RD"}, {"family": "Summers", "given": "Charlotte", "initials": "C"}, {"family": "Thompson", "given": "Taylor B", "initials": "TB"}, {"family": "Valente Barbas", "given": "Carmen S", "initials": "CS"}, {"family": "Villar", "given": "Jes\u00fas", "initials": "J"}, {"family": "Ware", "given": "Lorraine B", "initials": "LB"}, {"family": "Weiss", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Zampieri", "given": "Fernando G", "initials": "FG"}, {"family": "Azoulay", "given": "Elie", "initials": "E"}, {"family": "Cecconi", "given": "Maurizio", "initials": "M"}, {"family": "European Society of Intensive Care Medicine Taskforce on ARDS", "given": "", "initials": ""}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "issn-l": "0342-4642", "volume": "49", "issue": "7", "pages": "727-759"}, "abstract": "The aim of these guidelines is to update the 2017 clinical practice guideline (CPG) of the European Society of Intensive Care Medicine (ESICM). The scope of this CPG is limited to adult patients and to non-pharmacological respiratory support strategies across different aspects of acute respiratory distress syndrome (ARDS), including ARDS due to coronavirus disease 2019 (COVID-19). These guidelines were formulated by an international panel of clinical experts, one methodologist and patients' representatives on behalf of the ESICM. The review was conducted in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement recommendations. We followed the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to assess the certainty of evidence and grade recommendations and the quality of reporting of each study based on the EQUATOR (Enhancing the QUAlity and Transparency Of health Research) network guidelines. The CPG addressed 21 questions and formulates 21 recommendations on the following domains: (1) definition; (2) phenotyping, and respiratory support strategies including (3) high-flow nasal cannula oxygen (HFNO); (4) non-invasive ventilation (NIV); (5) tidal volume setting; (6) positive end-expiratory pressure (PEEP) and recruitment maneuvers (RM); (7) prone positioning; (8) neuromuscular blockade, and (9) extracorporeal life support (ECLS). In addition, the CPG includes expert opinion on clinical practice and identifies the areas of future research.", "doi": "10.1007/s00134-023-07050-7", "pmid": "37326646", "labels": {"Category: Health": null, "Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10354163"}, {"db": "pii", "key": "10.1007/s00134-023-07050-7"}], "notes": [], "created": "2023-10-04T09:33:16.169Z", "modified": "2023-10-04T11:21:30.227Z"}, {"entity": "publication", "iuid": "2c8feac8e069488c974dd20db5646552", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c8feac8e069488c974dd20db5646552.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c8feac8e069488c974dd20db5646552"}}, "title": "Does misclassification of former tobacco smokers explain the 'smoker's paradox' in the risk of COVID-19? Insights from the Stockholm Public Health Cohort.", "authors": [{"family": "Shaaban", "given": "Ahmed N", "initials": "AN", "orcid": "0000-0001-8483-638X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b418a223c2054c459cc35896e4ee98db.json"}}, {"family": "Andersson", "given": "Filip", "initials": "F"}, {"family": "Magnusson", "given": "Cecilia", "initials": "C"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}, {"family": "Caspersen", "given": "Ida H", "initials": "IH"}, {"family": "Pe\u00f1a", "given": "Sebastian", "initials": "S"}, {"family": "Karvonen", "given": "Sakari", "initials": "S"}, {"family": "Magnus", "given": "Per", "initials": "P"}, {"family": "Galanti", "given": "Maria R", "initials": "MR", "orcid": "0000-0002-7805-280X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8bc2f32ea87d4ddc9710aad0834aafc5.json"}}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": "51", "issue": "5", "pages": "735-743"}, "abstract": "The association between tobacco smoking and the risk of COVID-19 and its adverse outcomes is controversial, as studies reported contrasting findings. Bias due to misclassification of the exposure in the analyses of current versus non-current smoking could be a possible explanation because former smokers may have higher background risks of the disease due to co-morbidity. The aim of the study was to investigate the extent of this potential bias by separating non-, former, and current smokers when assessing the risk or prognosis of diseases.\r\n\r\nWe analysed data from 43,400 participants in the Stockholm Public Health Cohort, Sweden, with information on smoking obtained prior to the pandemic. We estimated the risk of COVID-19, hospital admissions and death for (a) former and current smokers relative to non-smokers, (b) current smokers relative to non-current smokers, that is, including former smokers; adjusting for potential confounders (aRR).\r\n\r\nThe aRR of a COVID-19 diagnosis was elevated for former smokers compared with non-smokers (1.07; 95% confidence interval (CI) =1.00-1.15); including hospital admission with any COVID-19 diagnosis (aRR= 1.23; 95% CI = 1.03-1.48); or with COVID-19 as the main diagnosis (aRR=1.23, 95% CI= 1.01-1.49); and death within 30 days with COVID-19 as the main or a contributory cause (aRR=1.40; 95% CI=1.00-1.95). Current smoking was negatively associated with risk of COVID-19 (aRR=0.79; 95% CI=0.68-0.91).\r\n\r\nSeparating non-smokers from former smokers when assessing the disease risk or prognosis is essential to avoid bias. However, the negative association between current smoking and the risk of COVID-19 could not be entirely explained by misclassification.", "doi": "10.1177/14034948231174279", "pmid": "37165603", "labels": {"Category: Public Health": null, "Funder: NordForsk": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10183343"}], "notes": [], "created": "2023-10-04T05:09:46.201Z", "modified": "2023-10-04T06:08:29.155Z"}, {"entity": "publication", "iuid": "3dd75d5ee69a4397abe43b08a078fe21", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3dd75d5ee69a4397abe43b08a078fe21.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3dd75d5ee69a4397abe43b08a078fe21"}}, "title": "Cost Effectiveness of Strategies for Caring for Critically Ill Patients with COVID-19 in Tanzania.", "authors": [{"family": "Shah", "given": "Hiral Anil", "initials": "HA", "orcid": "0000-0003-0204-451X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21ddc194342b4a8280e1c0977ced1d43.json"}}, {"family": "Baker", "given": "Tim", "initials": "T", "orcid": "0000-0001-8727-7018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1454fc20049b4d47865268adf16d104a.json"}}, {"family": "Schell", "given": "Carl Otto", "initials": "CO", "orcid": "0000-0002-7904-1336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a40b337b45b471d97a102c355c9d874.json"}}, {"family": "Kuwawenaruwa", "given": "August", "initials": "A", "orcid": "0000-0001-8459-443X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cbb1004e55d04aa6831d0f1ac9c51233.json"}}, {"family": "Awadh", "given": "Khamis", "initials": "K"}, {"family": "Khalid", "given": "Karima", "initials": "K", "orcid": "0000-0001-9917-9853", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7c34a2daebf4e0483d0de27357ce4db.json"}}, {"family": "Kairu", "given": "Angela", "initials": "A", "orcid": "0000-0002-0965-4460", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/655a16b5d0704794a9183726b74eee30.json"}}, {"family": "Were", "given": "Vincent", "initials": "V", "orcid": "0000-0002-3554-795X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59d578f5fe6d4fa0b015dc1fd609c932.json"}}, {"family": "Barasa", "given": "Edwine", "initials": "E", "orcid": "0000-0001-5793-7177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0487b77768174459af77fa6456cf5954.json"}}, {"family": "Baker", "given": "Peter", "initials": "P", "orcid": "0000-0001-9028-9976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/117923062b604fc0b2206c9adeef38b1.json"}}, {"family": "Guinness", "given": "Lorna", "initials": "L", "orcid": "0000-0002-1013-4200", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bf8da5dd3e24b669b1f58ea651be77a.json"}}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Pharmacoecon Open", "issn": "2509-4254", "issn-l": null, "volume": "7", "issue": "4", "pages": "537-552"}, "abstract": "The resources for critical care are limited in many settings, exacerbating the significant morbidity and mortality associated with critical illness. Budget constraints can lead to choices between investing in advanced critical care (e.g. mechanical ventilators in intensive care units) or more basic critical care such as Essential Emergency and Critical Care (EECC; e.g. vital signs monitoring, oxygen therapy, and intravenous fluids).\r\n\r\nWe investigated the cost effectiveness of providing EECC and advanced critical care in Tanzania in comparison with providing 'no critical care' or 'district hospital-level critical care' using coronavirus disease 2019 (COVID-19) as a tracer condition. We developed an open-source Markov model ( https://github.com/EECCnetwork/POETIC_CEA ) to estimate costs and disability-adjusted life-years (DALYs) averted, using a provider perspective, a 28-day time horizon, patient outcomes obtained from an elicitation method involving a seven-member expert group, a normative costing study, and published literature. We performed a univariate and probabilistic sensitivity analysis to assess the robustness of our results.\r\n\r\nEECC is cost effective 94% and 99% of the time when compared with no critical care (incremental cost-effectiveness ratio [ICER] $37 [-$9 to $790] per DALY averted) and district hospital-level critical care (ICER $14 [-$200 to $263] per DALY averted), respectively, relative to the lowest identified estimate of the willingness-to-pay threshold for Tanzania ($101 per DALY averted). Advanced critical care is cost effective 27% and 40% of the time, when compared with the no critical care or district hospital-level critical care scenarios, respectively.\r\n\r\nFor settings where there is limited or no critical care delivery, implementation of EECC could be a highly cost-effective investment. It could reduce mortality and morbidity for critically ill COVID-19 patients, and its cost effectiveness falls within the range considered 'highly cost effective'. Further research is needed to explore the potential of EECC to generate even greater benefits and value for money when patients with diagnoses other than COVID-19 are accounted for.", "doi": "10.1007/s41669-023-00418-x", "pmid": "37178434", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10181924"}, {"db": "pii", "key": "10.1007/s41669-023-00418-x"}], "notes": [], "created": "2023-10-04T05:11:10.509Z", "modified": "2023-10-04T07:08:57.586Z"}, {"entity": "publication", "iuid": "08c5680512c54af484164d9feb458e04", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/08c5680512c54af484164d9feb458e04.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/08c5680512c54af484164d9feb458e04"}}, "title": "Association between hypersomnolence and the COVID-19 pandemic: The International COVID-19 Sleep Study (ICOSS).", "authors": [{"family": "Sarkanen", "given": "Tomi", "initials": "T"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Merikanto", "given": "Ilona", "initials": "I"}, {"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Nadorff", "given": "Michael R", "initials": "MR"}, {"family": "Bolstad", "given": "Courtney J", "initials": "CJ"}, {"family": "Espie", "given": "Colin", "initials": "C"}, {"family": "Matsui", "given": "Kentaro", "initials": "K"}, {"family": "Chung", "given": "Frances", "initials": "F"}, {"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK"}, {"family": "Penzel", "given": "Thomas", "initials": "T"}, {"family": "Mac\u00eado", "given": "Tain\u00e1", "initials": "T"}, {"family": "Mota-Rolim", "given": "S\u00e9rgio", "initials": "S"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Plazzi", "given": "Giuseppe", "initials": "G"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L"}, {"family": "Landtblom", "given": "Anne-Marie", "initials": "A"}, {"family": "Inoue", "given": "Yuichi", "initials": "Y"}, {"family": "Sieminski", "given": "Mariuz", "initials": "M"}, {"family": "Leger", "given": "Damien", "initials": "D"}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y"}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Sleep Med", "issn": "1878-5506", "issn-l": null, "volume": "107", "issue": null, "pages": "108-115"}, "abstract": "The COVID-19 pandemic and related restriction measures have affected our daily life, sleep, and circadian rhythms worldwide. Their effects on hypersomnolence and fatigue remain unclear.\r\n\r\nThe International COVID-19 Sleep Study questionnaire which included items on hypersomnolence such as excessive daytime sleepiness (EDS), and excessive quantity of sleep (EQS), as well as sociodemographic factors, sleep patterns, psychological symptoms, and quality of life was distributed in 15 countries across the world from May to September in 2020.\r\n\r\nAltogether responses from 18,785 survey participants (65% women, median age 39 years) were available for analysis. Only 2.8% reported having had COVID-19. Compared to before the pandemic, the prevalence of EDS, EQS, and fatigue increased from 17.9% to 25.5%, 1.6%-4.9%, and 19.4%-28.3% amid the pandemic, respectively. In univariate logistic regression models, reports of having a COVID-19 were associated with EQS (OR 5.3; 95%-CI 3.6-8.0), EDS (2.6; 2.0-3.4), and fatigue (2.8; 2.1-3.6). In adjusted multivariate logistic regression, sleep duration shorter than desired (3.9; 3.2-4.7), depressive symptoms (3.1; 2.7-3.5), use of hypnotics (2.3; 1.9-2.8), and having reported COVID-19 (1.9; 1.3-2.6) remained strong predictors of EDS. Similar associations emerged for fatigue. In the multivariate model, depressive symptoms (4.1; 3.6-4.6) and reports of having COVID-19 (2.0; 1.4-2.8) remained associated with EQS.\r\n\r\nA large increase in EDS, EQS, and fatigue occurred due to the COVID-19 pandemic, and especially in self-reported cases of COVID-19. These findings warrant a thorough understanding of their pathophysiology to target prevention and treatment strategies for long COVID condition.", "doi": "10.1016/j.sleep.2023.04.024", "pmid": "37156053", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10163923"}, {"db": "pii", "key": "S1389-9457(23)00160-0"}], "notes": [], "created": "2023-10-04T05:10:28.509Z", "modified": "2023-10-04T06:43:00.331Z"}, {"entity": "publication", "iuid": "49656b81c61e436191b96dbd34ab2c02", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49656b81c61e436191b96dbd34ab2c02.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49656b81c61e436191b96dbd34ab2c02"}}, "title": "Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia in middle-income countries.", "authors": [{"family": "van de Munckhof", "given": "Anita", "initials": "A", "orcid": "0000-0001-6028-3426", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e0cc819c9fe4a0b89beb8c30ea0b6b6.json"}}, {"family": "Borhani-Haghighi", "given": "Afshin", "initials": "A", "orcid": "0000-0002-4131-7990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f8cc4b1e730435092ab97b92bbe4d36.json"}}, {"family": "Aaron", "given": "Sanjith", "initials": "S", "orcid": "0000-0002-5151-1500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98fdfb1034344016b5f0c16e10963382.json"}}, {"family": "Krzywicka", "given": "Katarzyna", "initials": "K"}, {"family": "van Kammen", "given": "Mayte S\u00e1nchez", "initials": "MS"}, {"family": "Cordonnier", "given": "Charlotte", "initials": "C"}, {"family": "Kleinig", "given": "Timothy J", "initials": "TJ"}, {"family": "Field", "given": "Thalia S", "initials": "TS", "orcid": "0000-0002-1176-0633", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f08f5ddffb74ae796f60cdf39b3ef8c.json"}}, {"family": "Poli", "given": "Sven", "initials": "S", "orcid": "0000-0002-0286-8781", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c953f4fa37054db9b0ea7127a5593847.json"}}, {"family": "Lemmens", "given": "Robin", "initials": "R"}, {"family": "Scutelnic", "given": "Adrian", "initials": "A"}, {"family": "Lindgren", "given": "Erik", "initials": "E"}, {"family": "Duan", "given": "Jiangang", "initials": "J"}, {"family": "Arslan", "given": "Y\u0131ld\u0131z", "initials": "Y"}, {"family": "van Gorp", "given": "Eric Cm", "initials": "EC"}, {"family": "Kremer Hovinga", "given": "Johanna A", "initials": "JA"}, {"family": "G\u00fcnther", "given": "Albrecht", "initials": "A"}, {"family": "Jood", "given": "Katarina", "initials": "K"}, {"family": "Tatlisumak", "given": "Turgut", "initials": "T"}, {"family": "Putaala", "given": "Jukka", "initials": "J"}, {"family": "Heldner", "given": "Mirjam R", "initials": "MR"}, {"family": "Arnold", "given": "Marcel", "initials": "M"}, {"family": "de Sousa", "given": "Diana Aguiar", "initials": "DA", "orcid": "0000-0002-6702-7924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cc3515119a247859fe1fea025f703ef.json"}}, {"family": "Wasay", "given": "Mohammad", "initials": "M", "orcid": "0000-0003-3750-2613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d31625317cd48779278fb20fee594a8.json"}}, {"family": "Arauz", "given": "Antonio", "initials": "A"}, {"family": "Conforto", "given": "Adriana Bastos", "initials": "AB"}, {"family": "Ferro", "given": "Jos\u00e9 M", "initials": "JM", "orcid": "0000-0002-2343-9097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c8285bcf71c4ed1aa7b57a13c5cb70a.json"}}, {"family": "Coutinho", "given": "Jonathan M", "initials": "JM"}, {"family": "Cerebral Venous Sinus Thrombosis with Thrombocytopenia Syndrome Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-06-30", "journal": {"title": "Int J Stroke", "issn": "1747-4949", "issn-l": null, "volume": null, "issue": null, "pages": "17474930231182901"}, "abstract": "Adenovirus-based COVID-19 vaccines are extensively used in low- and middle-income countries (LMICs). Remarkably, cases of cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) have rarely been reported from LMICs.\r\n\r\nWe studied the frequency, manifestations, treatment, and outcomes of CVST-VITT in LMICs.\r\n\r\nWe report data from an international registry on CVST after COVID-19 vaccination. VITT was classified according to the Pavord criteria. We compared CVST-VITT cases from LMICs to cases from high-income countries (HICs).\r\n\r\nUntil August 2022, 228 CVST cases were reported, of which 63 were from LMICs (all middle-income countries [MICs]: Brazil, China, India, Iran, Mexico, Pakistan, Turkey). Of these 63, 32 (51%) met the VITT criteria, compared to 103 of 165 (62%) from HICs. Only 5 of the 32 (16%) CVST-VITT cases from MICs had definite VITT, mostly because anti-platelet factor 4 antibodies were often not tested. The median age was 26 (interquartile range [IQR] 20-37) versus 47 (IQR 32-58) years, and the proportion of women was 25 of 32 (78%) versus 77 of 103 (75%) in MICs versus HICs, respectively. Patients from MICs were diagnosed later than patients from HICs (1/32 [3%] vs. 65/103 [63%] diagnosed before May 2021). Clinical manifestations, including intracranial hemorrhage, were largely similar as was intravenous immunoglobulin use. In-hospital mortality was lower in MICs (7/31 [23%, 95% confidence interval (CI) 11-40]) than in HICs (44/102 [43%, 95% CI 34-53], p = 0.039).\r\n\r\nThe number of CVST-VITT cases reported from LMICs was small despite the widespread use of adenoviral vaccines. Clinical manifestations and treatment of CVST-VITT cases were largely similar in MICs and HICs, while mortality was lower in patients from MICs.", "doi": "10.1177/17474930231182901", "pmid": "37277922", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:32:36.532Z", "modified": "2023-10-04T11:12:08.100Z"}, {"entity": "publication", "iuid": "b5297743cde049d68ec810db8b68c822", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5297743cde049d68ec810db8b68c822.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5297743cde049d68ec810db8b68c822"}}, "title": "Post-COVID sequelae effect in chronic fatigue syndrome: SARS-CoV-2 triggers latent adenovirus in the oral mucosa.", "authors": [{"family": "Hannestad", "given": "Ulf", "initials": "U"}, {"family": "Apostolou", "given": "Eirini", "initials": "E"}, {"family": "Sj\u00f6gren", "given": "Per", "initials": "P"}, {"family": "Brag\u00e9e", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Polo", "given": "Olli", "initials": "O"}, {"family": "Bertilson", "given": "Bo Christer", "initials": "BC"}, {"family": "Ros\u00e9n", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2023-06-29", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "issn-l": null, "volume": "10", "issue": null, "pages": "1208181"}, "abstract": "The post-viral fatigue syndromes long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have multiple, potentially overlapping, pathological processes. These include persisting reservoirs of virus, e.g., SARS-CoV-2 in long COVID patient's tissues, immune dysregulation with or without reactivation of underlying pathogens, such as Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV6), as we recently described in ME/CFS, and possibly yet unidentified viruses. In the present study we tested saliva samples from two cohorts for IgG against human adenovirus (HAdV): patients with ME/CFS (n = 84) and healthy controls (n = 94), with either mild/asymptomatic SARS-CoV-2 infection or no infection. A significantly elevated anti-HAdV IgG response after SARS-CoV-2 infection was detected exclusively in the patient cohort. Longitudinal/time analysis, before and after COVID-19, in the very same individuals confirmed HAdV IgG elevation after. In plasma there was no HAdV IgG elevation. We conclude that COVID-19 triggered reactivation of dormant HAdV in the oral mucosa of chronic fatigue patients indicating an exhausted dysfunctional antiviral immune response in ME/CFS, allowing reactivation of adenovirus upon stress encounter such as COVID-19. These novel findings should be considered in clinical practice for identification of patients that may benefit from therapy that targets HAdV as well.", "doi": "10.3389/fmed.2023.1208181", "pmid": "37457558", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC10349329"}], "notes": [], "created": "2023-10-04T12:07:38.054Z", "modified": "2023-10-04T12:21:18.720Z"}, {"entity": "publication", "iuid": "3fa5cfcbec3f42e798406ff5e9e3d1d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3fa5cfcbec3f42e798406ff5e9e3d1d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3fa5cfcbec3f42e798406ff5e9e3d1d9"}}, "title": "One year safety and immunogenicity of AZD1222 (ChAdOx1 nCoV-19): Final analysis of a randomized, placebo-controlled phase 1/2 trial in Japan.", "authors": [{"family": "Ishikawa", "given": "Kensuke", "initials": "K"}, {"family": "Nascimento", "given": "Maria-Claudia", "initials": "M"}, {"family": "Asano", "given": "Michiko", "initials": "M"}, {"family": "Hirata", "given": "Hajime", "initials": "H"}, {"family": "Itoh", "given": "Yohji", "initials": "Y"}, {"family": "Kelly", "given": "Elizabeth J", "initials": "EJ"}, {"family": "Matsui", "given": "Akiko", "initials": "A"}, {"family": "Olsson", "given": "Urban", "initials": "U"}, {"family": "Shoemaker", "given": "Kathryn", "initials": "K"}, {"family": "Green", "given": "Justin", "initials": "J"}], "type": "randomized controlled trial", "published": "2023-06-29", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null, "volume": "41", "issue": "29", "pages": "4199-4205"}, "abstract": "Long duration trial data for two-dose COVID-19 vaccines primary series' are uncommon due to unblinding and additional doses. We report one-year follow-up results from a phase 1/2 trial of AZD1222 (ChAdOx1 nCoV-19) in Japan.\r\n\r\nAdults (n = 256) seronegative for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) were stratified by age, 18-55 (n = 128), 56-69 (n = 86) and \u226570-year-old (n = 42), and randomized 3:1 to AZD1222 or placebo. Safety, immunogenicity, and exploratory efficacy data were collected until study Day 365.\r\n\r\nSafety was consistent with previous reports. In AZD1222 vaccinees, humoral responses against SARS-CoV-2 steadily declined over time. By Day 365, anti-SARS-CoV-2 spike-binding (spike) and receptor-binding domain (RBD) mean antibody titers remained above Day 15 levels and pseudovirus neutralizing antibodies were undetectable in many participants.\r\n\r\nAZD1222 is immunogenic and well tolerated in Japanese adults. Expected waning in anti-SARS-CoV-2 humoral responses was observed; spike and RBD antibody titers remained elevated. (ClinicalTrials.gov: NCT04568031).", "doi": "10.1016/j.vaccine.2023.05.015", "pmid": "37271703", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10237326"}, {"db": "pii", "key": "S0264-410X(23)00542-X"}, {"db": "ClinicalTrials.gov", "key": "NCT04568031"}], "notes": [], "created": "2023-10-04T09:30:12.084Z", "modified": "2023-10-04T09:51:35.301Z"}, {"entity": "publication", "iuid": "cca3bfbe17894d229c006db8e4a464d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cca3bfbe17894d229c006db8e4a464d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cca3bfbe17894d229c006db8e4a464d7"}}, "title": "Changes in trauma-related emergency medical services during the COVID-19 lockdown in the Western Cape, South Africa.", "authors": [{"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Stassen", "given": "Willem", "initials": "W"}, {"family": "Laflamme", "given": "Lucie", "initials": "L"}, {"family": "Wallis", "given": "Lee Alan", "initials": "LA"}, {"family": "Hasselberg", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2023-06-27", "journal": {"title": "BMC Emerg Med", "issn": "1471-227X", "issn-l": null, "volume": "23", "issue": "1", "pages": "72"}, "abstract": "To limit virus spread during the COVID pandemic, extensive measures were implemented around the world. In South Africa, these restrictions included alcohol and movement restrictions, factors previously linked to injury burden in the country. Consequently, reports from many countries, including South Africa, have shown a reduction in trauma presentations related to these restrictions. However, only few studies and none from Africa focus on the impact of the pandemic restrictions on the Emergency Medical System (EMS).\r\n\r\nWe present a retrospective, observational longitudinal study including data from all ambulance transports of physical trauma cases collected during the period 2019-01-01 and 2021-02-28 from the Western Cape Government EMS in the Western Cape Province, South Africa (87,167 cases). Within this timeframe, the 35-days strictest lockdown level period was compared to a 35-days period prior to the lockdown and to the same 35-days period in 2019. Injury characteristics (intent, mechanism, and severity) and time were studied in detail. Ambulance transport volumes as well as ambulance response and on-scene time before and during the pandemic were compared. Significance between indicated periods was determined using Chi-square test.\r\n\r\nDuring the strictest lockdown period, presentations of trauma cases declined by > 50%. Ambulance transport volumes decreased for all injury mechanisms and proportions changed. The share of assaults and traffic injuries decreased by 6% and 8%, respectively, while accidental injuries increased by 5%. The proportion of self-inflicted injuries increased by 5%. Studies of injury time showed an increased share of injuries during day shift and a reduction of total injury volume during the weekend during the lockdown. Median response- and on-scene time remained stable in the time-periods studied.\r\n\r\nThis is one of the first reports on the influence of COVID-19 related restrictions on EMS, and the first in South Africa. We report a decline in trauma related ambulance transport volumes in the Western Cape Province as well as changes in injury patterns, largely corresponding to previous findings from hospital settings in South Africa. The unchanged response and on-scene times indicate a well-functioning EMS despite pandemic challenges. More studies are needed, especially disaggregating the different restrictions.", "doi": "10.1186/s12873-023-00840-8", "pmid": "37370047", "labels": {"Category: Health": null, "Category: Other": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10304331"}, {"db": "pii", "key": "10.1186/s12873-023-00840-8"}], "notes": [], "created": "2023-10-04T09:33:06.004Z", "modified": "2023-10-04T11:16:08.902Z"}, {"entity": "publication", "iuid": "2b0291b59f914953869fbec4b66b3bd4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b0291b59f914953869fbec4b66b3bd4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b0291b59f914953869fbec4b66b3bd4"}}, "title": "Students at a crossroad: A cross-sectional survey gauging the impact of COVID-19 on medical and biomedical graduates in the United States and Sweden.", "authors": [{"family": "Lange", "given": "Stephan", "initials": "S", "orcid": "0000-0001-9361-6602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d15f59268b2e47c58612b025e48707bb.json"}}, {"family": "Sot\u00e1k", "given": "Mat\u00fa\u0161", "initials": "M", "orcid": "0000-0002-9984-9340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/238be0180b0f499f9eb0fe69d7b0389a.json"}}, {"family": "Hagberg", "given": "Carolina E", "initials": "CE"}, {"family": "Bagunu", "given": "Grace", "initials": "G"}, {"family": "Vigmo", "given": "Sylvi", "initials": "S"}, {"family": "B\u00f6rgeson", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2023-06-24", "journal": {"title": "Biochem Mol Biol Educ", "issn": "1539-3429", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Graduate programs in medicine and biomedical sciences have been severely impacted by the SARS-CoV-2/COVID-19 pandemic over the last 2 years. Following 2 years since beginning of the pandemic, data on student support, educational and academic performance as well as sentiment on changes to educational programs are starting to emerge. We performed and compared results of two cross-sectional surveys of Swedish and U.S.-based medical and biomedical graduate students on how the pandemic has affected their studies, research productivity and career trajectory. Students were also asked to assess support provided by the university and supervisors. The surveys also captured student demographics and a range of other factors, such as pressures brought on by caretaking and financial responsibilities. We analyzed answers from 264 and 106 students attending graduate programs in universities in Sweden and the United States, respectively. U.S.-based students faced more severe restrictions on their research program compared to students in Sweden, reporting more delays in productivity, scientific output and graduation, and increased worries about their career trajectory. Swedish students had more caretaking responsibilities, although these did not cause any delays in graduation. While support by universities and supervisors was comparable between the countries, financial worries and mental health concerns were particularly prominent in the U.S. cohort. Student performance and outlook was hugely dependent on the breadth of the restrictions and the available support. Besides the governmental and university-led approach to counter the pandemic, societal differences also played a role in how well students were handling effects of the pandemic.", "doi": "10.1002/bmb.21761", "pmid": "37354049", "labels": {"Category: Social Science & Humanities": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:30:48.915Z", "modified": "2023-10-04T10:05:44.722Z"}, {"entity": "publication", "iuid": "a9ee88d043544386b7c7616bb638f012", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a9ee88d043544386b7c7616bb638f012.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a9ee88d043544386b7c7616bb638f012"}}, "title": "Patient reported experiences of Swedish patients being investigated for cancer during the Covid-19 pandemic.", "authors": [{"family": "Tufvesson Stiller", "given": "Helena", "initials": "H", "orcid": "0000-0001-5213-9555", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9e04f2b00a5436192e564e3b0af08cb.json"}}, {"family": "Schmitt-Egenolf", "given": "Marcus", "initials": "M", "orcid": "0000-0002-3858-8474", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84d3fdbf4946483b9651365b34f2333e.json"}}, {"family": "Fohlin", "given": "Helena", "initials": "H", "orcid": "0000-0003-4336-0949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/142b56d58aec4dfab0f217cb3e334a52.json"}}, {"family": "Uppugunduri", "given": "Srinivas", "initials": "S", "orcid": "0000-0003-0572-5580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e6b350c35264d8db2606af67303deed.json"}}], "type": "journal article", "published": "2023-06-24", "journal": {"title": "Support Care Cancer", "issn": "1433-7339", "issn-l": null, "volume": "31", "issue": "7", "pages": "416"}, "abstract": "Patient reported experiences in individuals being investigated for cancer have been recorded in a nationwide survey in Sweden, providing an opportunity to assess the impact of the Covid-19-pandemic.\r\n\r\nQuestionnaires from 45920 patients were analyzed to assess the experience of being investigated for cancer. Data from before the Covid-19-pandemic (2018-2019) was compared to data acquired during the pandemic (2020-2021), using chi-square and Wilcoxon rank sum tests. Both, patients who were cleared from suspicion of cancer and those who were diagnosed with cancer were included.\r\n\r\nFewer patients in total visited health services during the pandemic. However, patients that did seek help did so to a similar extent during as prior to the pandemic. Patient waiting time was perceived to be shorter during the pandemic and judged as neither too long nor too short by most patients. The emotional support to patients improved during the pandemic, whereas the support to next of kin declined. A majority of patients received the results from the investigation in a meeting with the physician. Although there was a preference for receiving results in a meeting with the physician, the pandemic has brought an increasing interest in receiving results by phone.\r\n\r\nSwedish cancer healthcare has shown resilience during the Covid-19-pandemic, maintaining high patient satisfaction while working under conditions of extraordinary pressure. Patients became more open to alternatives to physical \"in person\" health care visits which could lead to more digital visits in the future. However, support to significant others demands special attention.", "doi": "10.1007/s00520-023-07897-y", "pmid": "37354327", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10290588"}, {"db": "pii", "key": "10.1007/s00520-023-07897-y"}], "notes": [], "created": "2023-10-04T09:31:03.603Z", "modified": "2023-10-04T10:41:54.531Z"}, {"entity": "publication", "iuid": "b574a09ae6e4410d84166c128e63fc42", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b574a09ae6e4410d84166c128e63fc42.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b574a09ae6e4410d84166c128e63fc42"}}, "title": "Pulmonary embolism and deep venous thrombosis after COVID-19: long-term risk in a population-based cohort study.", "authors": [{"family": "Sjoland", "given": "Helen", "initials": "H"}, {"family": "Lindgren", "given": "Martin", "initials": "M"}, {"family": "Toska", "given": "Triantafyllia", "initials": "T"}, {"family": "Hansson", "given": "Per-Olof", "initials": "P"}, {"family": "Sandblad", "given": "Katarina Glise", "initials": "KG"}, {"family": "Alex", "given": "Christian", "initials": "C"}, {"family": "Bjorck", "given": "Lena", "initials": "L"}, {"family": "Cronie", "given": "Ottmar", "initials": "O"}, {"family": "Bjork", "given": "Jonas", "initials": "J"}, {"family": "Lundberg", "given": "Christina E", "initials": "CE"}, {"family": "Adiels", "given": "Martin", "initials": "M"}, {"family": "Rosengren", "given": "Annika", "initials": "A"}], "type": "journal article", "published": "2023-06-21", "journal": {"title": "Res Pract Thromb Haemost", "issn": "2475-0379", "issn-l": null, "volume": "7", "issue": "5", "pages": "100284"}, "abstract": "Venous thromboembolism (VTE) (pulmonary embolism (PE) or deep venous thrombosis (DVT)) is common during acute COVID-19. Long-term excess risk has not yet been established.\r\n\r\nTo study long-term VTE risk after COVID-19.\r\n\r\nSwedish citizens aged 18-84 years, hospitalized and/or testing positive for COVID-19 between January 1, 2020, and September 11, 2021 (exposed), stratified by initial hospitalization, were compared to matched (1:5) non-exposed population-derived subjects without COVID-19. Outcomes were incident VTE, PE or DVT recorded within 60, 60-<180, and \u2265180 days. Cox regression was used for evaluation and a model adjusted for age, sex, comorbidities and socioeconomic markers developed to control for confounders.\r\n\r\nAmong exposed patients, 48,861 were hospitalized for COVID-19 (mean age 60.6 years) and 894,121 were without hospitalization (mean age 41.4 years). Among patients hospitalized for COVID-19, fully adjusted hazard ratios (HRs) during 60-<180 days were 6.05 (95% confidence interval (CI) 4.80\u25007.62) for PE and 3.97 (CI 2.96\u25005.33) for DVT, compared to non-exposed with corresponding estimates among COVID-19 without hospitalization 1.17 (CI 1.01\u25001.35) and 0.99 (CI 0.86\u25001.15), based on 475 and 2,311 VTE events, respectively. Long-term (\u2265180 days) HRs in patients hospitalized for COVID-19 were 2.01 (CI 1.51\u25002.68) for PE and 1.46 (CI 1.05\u25002.01) for DVT while non-hospitalized had similar risk to non-exposed, based on 467 and 2,030 VTE events, respectively.\r\n\r\nPatients hospitalized for COVID-19 retained an elevated excess risk of VTE, mainly PE, after 180 days, while long-term risk of VTE in individuals with COVID-19 without hospitalization was similar to the non-exposed.", "doi": "10.1016/j.rpth.2023.100284", "pmid": "37361398", "labels": {"Category: Health": null, "Category: Post-COVID": null, "Funder: VR": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10284449"}, {"db": "pii", "key": "S2475-0379(23)00184-X"}], "notes": [], "created": "2023-10-04T09:30:14.456Z", "modified": "2023-10-04T09:52:58.203Z"}, {"entity": "publication", "iuid": "9045fd55bc8e4a38aea3884a3373343a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9045fd55bc8e4a38aea3884a3373343a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9045fd55bc8e4a38aea3884a3373343a"}}, "title": "COVID-19-related stigma among infected people in Sweden; psychometric properties and levels of stigma in two cohorts as measured by a COVID-19 stigma scale.", "authors": [{"family": "Reinius", "given": "Maria", "initials": "M"}, {"family": "Svedhem", "given": "Veronica", "initials": "V"}, {"family": "Bruchfeld", "given": "Judith", "initials": "J"}, {"family": "Holmstr\u00f6m Larm", "given": "Heidi", "initials": "H"}, {"family": "Nygren-Bonnier", "given": "Malin", "initials": "M"}, {"family": "Eriksson", "given": "Lars E", "initials": "LE", "orcid": "0000-0001-5121-5325", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09bec95869bc450aa97e0aa11485807e.json"}}], "type": "journal article", "published": "2023-06-21", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "6", "pages": "e0287341"}, "abstract": "Epidemics have historically been accompanied by stigma and discrimination. Disease-related stigma has often been shown to have severe consequences for physical, mental and social wellbeing and lead to barriers to diagnosis, treatment and prevention. The aims of this study were to investigate if a HIV-related stigma measure could be adapted and valid and reliable to measure COVID-19-related stigma, and also to investigate levels of self-reported stigma and related factors among people in Sweden with experience of COVID-19 and compare levels of COVID-19-related stigma versus HIV-related stigma among persons living with HIV who had experienced a COVID-19 event.\r\n\r\nCognitive interviews (n = 11) and cross-sectional surveys were made after the acute phase of the illness using a new 12-item COVID-19 Stigma Scale and the established 12-item HIV Stigma Scale in two cohorts (people who had experienced COVID-19 (n = 166/209, 79%) and people living with HIV who had experienced a COVID-19 event (n = 50/91, 55%). Psychometric analysis of the COVID-19 Stigma Scale was performed by calculating floor and ceiling effects, Cronbach's \u03b1 and exploratory factor analysis. Levels of COVID-19 stigma between groups were analysed using the Mann-Whitney U test. Levels of COVID-19 and HIV stigma among people living with HIV with a COVID-19 event were compared using the Wilcoxon signed-rank test.\r\n\r\nThe COVID-19 cohort consisted of 88 (53%) men and 78 (47%) women, mean age 51 (19-80); 143 (87%) living in a higher and 22 (13%) in a lower income area. The HIV + COVID-19 cohort consisted of 34 (68%) men and 16 (32%) women, mean age 51 (26-79); 20 (40%) living in a higher and 30 (60%) in a lower income area. The cognitive interviews showed that the stigma items were easy to understand. Factor analysis suggested a four-factor solution accounting for 77% of the total variance. There were no cross loadings, but two items loaded on factors differing from the original scale. All subscales had acceptable internal consistency, showed high floor and no ceiling effects. There was no statistically significant difference between COVID-19 stigma scores between the two cohorts or between genders. People living in lower income areas reported more negative self-image and concerns about public attitudes related to COVID-19 than people in higher income areas (median score 3 vs 3 and 4 vs 3 on a scale from 3-12, Z = -1.980, p = 0.048 and Z = -2.023, p = 0.024, respectively). People from the HIV + COVID-19 cohort reported more HIV than COVID-19 stigma.\r\n\r\nThe adapted 12-item COVID-19 Stigma Scale may be valid and reliable for measurement of COVID-19-related stigma. However, specific items may need to be rephrased or replaced to better correspond to the COVID-19 context. People who had experienced COVID-19 reported low levels of COVID-19-related stigma in general but people from lower income areas had higher levels of negative self-image and concerns about public attitudes related to COVID-19 than people from areas with higher income, which may call for targeted interventions. Although exhibiting more pronounced HIV stigma levels, people living with HIV who had experienced COVID-19 reported COVID-19-related stigma of the same low magnitude as their peers not living with HIV.", "doi": "10.1371/journal.pone.0287341", "pmid": "37343027", "labels": {"Category: Social Science & Humanities": null, "Funder: VR": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10284413"}, {"db": "pii", "key": "PONE-D-22-35422"}], "notes": [], "created": "2023-10-04T09:30:07.232Z", "modified": "2023-10-04T09:48:40.291Z"}, {"entity": "publication", "iuid": "ae329cc718d04c629791e3fddd27d5ad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ae329cc718d04c629791e3fddd27d5ad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ae329cc718d04c629791e3fddd27d5ad"}}, "title": "Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity", "authors": [{"family": "Brunet-Ratnasingham", "given": "Elsa", "initials": "E", "orcid": "0000-0002-3613-1315", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae34faa98db04e62b0cdd39d9126b782.json"}}, {"family": "Morin", "given": "Sacha", "initials": "S"}, {"family": "Randolph", "given": "Haley E", "initials": "HE"}, {"family": "Labrecque", "given": "Marjorie", "initials": "M"}, {"family": "B\u00e9lair", "given": "Justin", "initials": "J"}, {"family": "Lima-Barbosa", "given": "Rapha\u00ebl", "initials": "R"}, {"family": "Pagliuzza", "given": "Am\u00e9lie", "initials": "A"}, {"family": "Marchitto", "given": "Lorie", "initials": "L"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Niessl", "given": "Julia", "initials": "J"}, {"family": "Cloutier", "given": "Rose", "initials": "R"}, {"family": "Sreng Flores", "given": "Alina M", "initials": "AM"}, {"family": "Brassard", "given": "Nathalie", "initials": "N"}, {"family": "Benlarbi", "given": "Mehdi", "initials": "M"}, {"family": "Pr\u00e9vost", "given": "J\u00e9r\u00e9mie", "initials": "J"}, {"family": "Ding", "given": "Shilei", "initials": "S"}, {"family": "Anand", "given": "Sai Priya", "initials": "SP"}, {"family": "Sannier", "given": "G\u00e9r\u00e9my", "initials": "G"}, {"family": "Bareke", "given": "Eric", "initials": "E"}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ee1510080704cf6a2a6972deb94123f.json"}}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Zhou", "given": "Sirui", "initials": "S"}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T", "orcid": "0000-0001-9510-5646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd273e50091d44c3b3e8d1473ce89b0a.json"}}, {"family": "Morrison", "given": "David", "initials": "D"}, {"family": "Vezina", "given": "Dani", "initials": "D"}, {"family": "Bourassa", "given": "Catherine", "initials": "C"}, {"family": "Gendron-Lepage", "given": "Gabrielle", "initials": "G"}, {"family": "Medjahed", "given": "Halima", "initials": "H"}, {"family": "Point", "given": "Floriane", "initials": "F"}, {"family": "Richard", "given": "Jonathan", "initials": "J"}, {"family": "Larochelle", "given": "Catherine", "initials": "C"}, {"family": "Prat", "given": "Alexandre", "initials": "A"}, {"family": "Arbour", "given": "Nathalie", "initials": "N"}, {"family": "Durand", "given": "Madeleine", "initials": "M"}, {"family": "Brent Richards", "given": "J", "initials": "J"}, {"family": "Moon", "given": "Kevin", "initials": "K"}, {"family": "Chomont", "given": "Nicolas", "initials": "N", "orcid": "0000-0001-9747-5018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/477cede6c34e4908a8e806f6352d3daa.json"}}, {"family": "Finzi", "given": "Andr\u00e9s", "initials": "A"}, {"family": "T\u00e9treault", "given": "Martine", "initials": "M"}, {"family": "Barreiro", "given": "Luis", "initials": "L"}, {"family": "Wolf", "given": "Guy", "initials": "G"}, {"family": "Kaufmann", "given": "Daniel E", "initials": "DE", "orcid": "0000-0003-4467-136X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9581da3f05024ef68e4ded53cb9b413c.json"}}], "type": "posted-content", "published": "2023-06-20", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.06.14.23290814", "pmid": null, "labels": {"Funder: VR": null, "Category: Genomics & transcriptomics": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Preprint": null, "Category: Serology": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:30:00.232Z", "modified": "2023-10-04T09:44:01.052Z"}, {"entity": "publication", "iuid": "4b5a011592d14e78a026c78150d0dd7b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b5a011592d14e78a026c78150d0dd7b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b5a011592d14e78a026c78150d0dd7b"}}, "title": "Lessons learned from pandemic response to COVID-19 in Bangladesh: NGO-based emergency response framework for low- and middle-income countries.", "authors": [{"family": "Ahmed", "given": "Tanvir", "initials": "T", "orcid": "0000-0001-8147-5136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f6ebfebcb3a40128282c0fe6bf61720.json"}}, {"family": "Musarrat", "given": "Parsa", "initials": "P", "orcid": "0000-0002-4210-5228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c80b1a7a9ea4952bf1b7653121b0e4f.json"}}, {"family": "Kabir", "given": "Zarina Nahar", "initials": "ZN", "orcid": "0000-0003-0465-5701", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7e6bafbfd6843e188acefca5ce929b1.json"}}], "type": "journal article", "published": "2023-06-20", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "issn-l": null, "volume": "23", "issue": "1", "pages": "656"}, "abstract": "Response to COVID-19 pandemic in Bangladesh was led by the Government of Bangladesh aided by Non-Government Organisations (NGO) among others. The aim of the study was to explore the activities of such an NGO to understand the philosophy, aspiration and strategy to plan and implement an effective response to COVID-19 pandemic in Bangladesh.\r\n\r\nA case study of a Bangladeshi NGO called SAJIDA Foundation (SF) is presented. From September to November 2021, using document review, field observation and in-depth interviews, four aspects of their COVID-19 pandemic related activities was explored - a) why and how SF initiated their COVID response; b) what adaptations were made to their usual programmes; c) how SF's response to COVID-19 were designed and what were the anticipated challenges including overcoming measures; and d) perception of the staff about SF's activities related to COVID-19. Fifteen in-depth interviews were conducted with three groups of SF staff: frontliners, managers and leaders.\r\n\r\nThe impact of COVID-19 has been beyond health emergencies and posed multidimensional challenges. SF took a two-pronged approach - aid the government to respond to the emergency and adopt an all-inclusive plan to address diverse challenges related to overall well-being of the population. The underlying strategy of their response has been to: define the challenge of COVID-19 and identify required expertise and resources, ensure people's health and social wellbeing, adjust existing organisational processes, ensure functional partnership with other organisations for effective resource and task sharing, and safeguard health and wellbeing of the organisation's own employees.\r\n\r\nThe findings suggest a '4C framework' including four components as the basis of a comprehensive response to emergencies by NGOs: 1. Capability assessment to identify who are in need and what is needed; 2. Collaboration with stakeholders to pool resources and expertise; 3. Compassionate leadership to ensure health and social safety of the employees which ensures their dedication in managing the emergency; and 4. Communication for quick and effective decision making, decentralisation, monitoring and coordination. It is expected that this '4C framework' can help NGOs to embark on a comprehensive response to manage emergencies in resource constrained low- and middle-income countries.", "doi": "10.1186/s12913-023-09643-w", "pmid": "37340495", "labels": {"Category: Social Science & Humanities": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC10283326"}, {"db": "pii", "key": "10.1186/s12913-023-09643-w"}], "notes": [], "created": "2023-10-04T09:30:46.347Z", "modified": "2023-10-04T10:03:45.896Z"}, {"entity": "publication", "iuid": "68a74d771c8a49bf9f26e13b0dd56271", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68a74d771c8a49bf9f26e13b0dd56271.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68a74d771c8a49bf9f26e13b0dd56271"}}, "title": "Drug interventions for prevention of COVID-19 progression to severe disease in outpatients: a systematic review with meta-analyses and trial sequential analyses (The LIVING Project).", "authors": [{"family": "Petersen", "given": "Johanne Juul", "initials": "JJ", "orcid": "0000-0001-9837-1958", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37a5ab98e9c2454599584fc77f72efe1.json"}}, {"family": "J\u00f8rgensen", "given": "Caroline Kamp", "initials": "CK", "orcid": "0000-0002-7756-4694", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1b41bcfde8a482ab3c137ca4124baa3.json"}}, {"family": "Faltermeier", "given": "Pascal", "initials": "P"}, {"family": "Siddiqui", "given": "Faiza", "initials": "F", "orcid": "0000-0002-8358-6259", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/444713ae12884f5cb2f5909e82be8170.json"}}, {"family": "Feinberg", "given": "Joshua", "initials": "J", "orcid": "0000-0003-1975-9300", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76c4aae6c02047078131ddaf618684f5.json"}}, {"family": "Nielsen", "given": "Emil Eik", "initials": "EE"}, {"family": "Torp Kristensen", "given": "Andreas", "initials": "A", "orcid": "0000-0002-4570-236X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d7e7db4d0ce4167a4ea31c1da5df461.json"}}, {"family": "Juul", "given": "Sophie", "initials": "S", "orcid": "0000-0002-6171-2904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76a1c669d07f4d559ae43063bb008b68.json"}}, {"family": "Holgersson", "given": "Johan", "initials": "J"}, {"family": "Nielsen", "given": "Niklas", "initials": "N"}, {"family": "Bentzer", "given": "Peter", "initials": "P"}, {"family": "Thabane", "given": "Lehana", "initials": "L", "orcid": "0000-0003-0355-9734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/499ab3d178774eaa9f6a44345dbf6a7c.json"}}, {"family": "Kwasi Korang", "given": "Steven", "initials": "S"}, {"family": "Klingenberg", "given": "Sarah", "initials": "S"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Jakobsen", "given": "Janus C", "initials": "JC"}], "type": "journal article", "published": "2023-06-20", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "6", "pages": "e064498"}, "abstract": "To assess the effects of interventions authorised by the European Medicines Agency (EMA) or the US Food and Drug Administration (FDA) for prevention of COVID-19 progression to severe disease in outpatients.\r\n\r\nOutpatient treatment.\r\n\r\nParticipants with a diagnosis of COVID-19 and the associated SARS-CoV-2 virus irrespective of age, sex and comorbidities.\r\n\r\nDrug interventions authorised by EMA or FDA.\r\n\r\nPrimary outcomes were all-cause mortality and serious adverse events.\r\n\r\nWe included 17 clinical trials randomising 16 257 participants to 8 different interventions authorised by EMA or FDA. 15/17 of the included trials (88.2%) were assessed at high risk of bias. Only molnupiravir and ritonavir-boosted nirmatrelvir seemed to improve both our primary outcomes. Meta-analyses showed that molnupiravir reduced the risk of death (relative risk (RR) 0.11, 95% CI 0.02 to 0.64; p=0.0145, 2 trials; very low certainty of evidence) and serious adverse events (RR 0.63, 95% CI 0.47 to 0.84; p=0.0018, 5 trials; very low certainty of evidence). Fisher's exact test showed that ritonavir-boosted nirmatrelvir reduced the risk of death (p=0.0002, 1 trial; very low certainty of evidence) and serious adverse events (p<0.0001, 1 trial; very low certainty of evidence) in 1 trial including 2246 patients, while another trial including 1140 patients reported 0 deaths in both groups.\r\n\r\nThe certainty of the evidence was very low, but, from the results of this study, molnupiravir showed the most consistent benefit and ranked highest among the approved interventions for prevention of COVID-19 progression to severe disease in outpatients. The lack of certain evidence should be considered when treating patients with COVID-19 for prevention of disease progression.\r\n\r\nCRD42020178787.", "doi": "10.1136/bmjopen-2022-064498", "pmid": "37339844", "labels": {"Category: Health": null, "Funder: VR": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10314423"}, {"db": "pii", "key": "bmjopen-2022-064498"}], "notes": [], "created": "2023-10-04T09:30:26.060Z", "modified": "2023-10-04T09:54:58.635Z"}, {"entity": "publication", "iuid": "f6cb2deed35b47a0a02ae2df7677df9f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6cb2deed35b47a0a02ae2df7677df9f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6cb2deed35b47a0a02ae2df7677df9f"}}, "title": "Diagnostic Usefulness of Spiroergometry and Risk Factors of Long COVID in Patients with Normal Left Ventricular Ejection Fraction.", "authors": [{"family": "Gryglewska-Wawrzak", "given": "Katarzyna", "initials": "K", "orcid": "0000-0001-7902-3042", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4d37e0f556244848e36712615c66efa.json"}}, {"family": "Sakowicz", "given": "Agata", "initials": "A", "orcid": "0000-0002-5083-2046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2ce71c0e6664383a44c8cc4cb61fcf3.json"}}, {"family": "Banach", "given": "Maciej", "initials": "M", "orcid": "0000-0001-6690-6874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/904a6969b0e244adb21ded395af3ac1a.json"}}, {"family": "Byty\u00e7i", "given": "Ibadete", "initials": "I", "orcid": "0000-0002-8996-4257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba2f218876104573a8e529b1c2b6f671.json"}}, {"family": "Bielecka-Dabrowa", "given": "Agata", "initials": "A", "orcid": "0000-0001-6666-3999", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b7cdcb731104a908bca628cd8b338e6.json"}}], "type": "journal article", "published": "2023-06-20", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "12", "issue": "12", "pages": null}, "abstract": "The emergence of the Coronavirus Disease 2019 (COVID-19) pandemic has brought forth various clinical manifestations and long-term complications, including a condition known as long COVID. Long COVID refers to a persistent set of symptoms that continue beyond the acute phase of the disease. This study investigated the risk factors and the utility of spiroergometry parameters for diagnosing patients with long COVID symptoms. The 146 patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with normal left ventricular ejection fraction and without respiratory diseases were included and divided into two groups: the group demonstrating long COVID symptoms [n = 44] and the group without long COVID symptoms [n = 102]. The clinical examinations, laboratory test results, echocardiography, non-invasive body mass analysis, and spiroergometry were evaluated. ClinicalTrials.gov Identifier: NCT04828629. Patients with long COVID symptoms had significantly higher age [58 (vs.) 44 years; p < 0.0001], metabolic age [53 vs. 45 years; p = 0.02)], left atrial diameter (LA) [37 vs. 35 mm; p = 0.04], left ventricular mass index (LVMI) [83 vs. 74 g/m2, p = 0.04], left diastolic filling velocity (A) [69 vs. 64 cm/s, p = 0.01], the ratio of peak velocity of early diastolic transmitral flow to peak velocity of early diastolic mitral annular motion (E/E') [7.35 vs. 6.05; p = 0.01], and a lower ratio of early to late diastolic transmitral flow velocity (E/A) [1.05 vs. 1.31; p = 0.01] compared to the control group. In cardiopulmonary exercise testing (CPET), long COVID patients presented lower forced vital capacity (FVC) [3.6 vs. 4.3 L; p < 0.0001], maximal oxygen consumption measured during incremental exercise indexed per kilogram (VO2max) [21 vs. 23 mL/min/kg; p = 0.04], respiratory exchange ratio (RER) [1.0 vs. 1.1; p = 0.04], forced expiratory volume in one second (FEV1) [2.90 vs. 3.25 L; p = 0.04], and a higher ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC%) [106 vs. 100%; p = 0.0002]. The laboratory results pointed out that patients with long COVID symptoms also had a lower rate of red blood cells (RBC) [4.4 vs. 4.6 \u00d7 106/uL; p = 0.01]; a higher level of glucose [92 vs. 90 mg/dL; p = 0.03]; a lower glomerular filtration rate (GFR) estimate by Modification of Diet in Renal Disease (MDRD) [88 vs. 95; p = 0.03]; and a higher level of hypersensitive cardiac Troponin T (hs-cTnT) [6.1 vs. 3.9 pg/mL; p = 0.04]. On the multivariate model, only FEV1/FVC% (OR 6.27, 95% CI: 2.64-14.86; p < 0.001) independently predicted the long COVID symptoms. Using the ROC analysis, the FEV1/FVC% \u2265 103 was the most powerful predictor of spiroergometry parameters (0.67 sensitive, 0.71 specific, AUC of 0.73; p < 0.001) in predicting the symptoms of long COVID. Spiroergometry parameters are useful in diagnosing long COVID and differentiating it from cardiovascular disease.", "doi": "10.3390/jcm12124160", "pmid": "37373853", "labels": {"Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10299442"}, {"db": "pii", "key": "jcm12124160"}, {"db": "ClinicalTrials.gov", "key": "NCT04828629"}], "notes": [], "created": "2023-10-04T09:32:51.948Z", "modified": "2023-10-04T11:13:26.785Z"}, {"entity": "publication", "iuid": "c7021304f6614e1aa11f020c15d29276", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7021304f6614e1aa11f020c15d29276.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7021304f6614e1aa11f020c15d29276"}}, "title": "Artificial intelligence-driven prediction of COVID-19-related hospitalization and death: a systematic review.", "authors": [{"family": "Shakibfar", "given": "Saeed", "initials": "S"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Zhao", "given": "Jing", "initials": "J"}, {"family": "Nordeng", "given": "Hedvig Marie Egeland", "initials": "HME"}, {"family": "Sandve", "given": "Geir Kjetil Ferkingstad", "initials": "GKF"}, {"family": "Pavlovic", "given": "Milena", "initials": "M"}, {"family": "Hajiebrahimi", "given": "Mohammadhossein", "initials": "M"}, {"family": "Andersen", "given": "Morten", "initials": "M"}, {"family": "Sessa", "given": "Maurizio", "initials": "M"}], "type": "systematic review", "published": "2023-06-20", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "1183725"}, "abstract": "To perform a systematic review on the use of Artificial Intelligence (AI) techniques for predicting COVID-19 hospitalization and mortality using primary and secondary data sources.\r\n\r\nCohort, clinical trials, meta-analyses, and observational studies investigating COVID-19 hospitalization or mortality using artificial intelligence techniques were eligible. Articles without a full text available in the English language were excluded.\r\n\r\nArticles recorded in Ovid MEDLINE from 01/01/2019 to 22/08/2022 were screened.\r\n\r\nWe extracted information on data sources, AI models, and epidemiological aspects of retrieved studies.\r\n\r\nA bias assessment of AI models was done using PROBAST.\r\n\r\nPatients tested positive for COVID-19.\r\n\r\nWe included 39 studies related to AI-based prediction of hospitalization and death related to COVID-19. The articles were published in the period 2019-2022, and mostly used Random Forest as the model with the best performance. AI models were trained using cohorts of individuals sampled from populations of European and non-European countries, mostly with cohort sample size <5,000. Data collection generally included information on demographics, clinical records, laboratory results, and pharmacological treatments (i.e., high-dimensional datasets). In most studies, the models were internally validated with cross-validation, but the majority of studies lacked external validation and calibration. Covariates were not prioritized using ensemble approaches in most of the studies, however, models still showed moderately good performances with Area under the Receiver operating characteristic Curve (AUC) values >0.7. According to the assessment with PROBAST, all models had a high risk of bias and/or concern regarding applicability.\r\n\r\nA broad range of AI techniques have been used to predict COVID-19 hospitalization and mortality. The studies reported good prediction performance of AI models, however, high risk of bias and/or concern regarding applicability were detected.", "doi": "10.3389/fpubh.2023.1183725", "pmid": "37408750", "labels": {"Funder: Forte": null, "Category: Public Health": null, "Category: Other": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: KAW/SciLifeLab": null, "Type: Review": null, "Funder: NordForsk": null}, "xrefs": [{"db": "pmc", "key": "PMC10319067"}], "notes": [], "created": "2023-10-04T12:09:35.195Z", "modified": "2023-10-04T12:57:56.322Z"}, {"entity": "publication", "iuid": "5ab564d97000495aac9c28ce671845c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5ab564d97000495aac9c28ce671845c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5ab564d97000495aac9c28ce671845c9"}}, "title": "Experiences of aftermath of COVID-19 in relation to social, financial and health related aspects among previously hospitalized patients: a qualitative exploration.", "authors": [{"family": "Nandonik", "given": "Ahmed Jojan", "initials": "AJ"}, {"family": "Das Pooja", "given": "Shangjucta", "initials": "S"}, {"family": "Ahmed", "given": "Tanvir", "initials": "T"}, {"family": "Parvez", "given": "Anwar", "initials": "A"}, {"family": "Kabir", "given": "Zarina Nahar", "initials": "ZN"}], "type": "journal article", "published": "2023-06-15", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "1196810"}, "abstract": "There is increasing evidence of long-term consequences of COVID-19. The world has seen multidimensional impact of the pandemic and Bangladesh is no exception to that. Policymakers in Bangladesh laid out strategies to curb the initial spread of COVID-19. However, long-term consequences of COVID-19 received little or no attention in the country. Evidence suggests that people presumed to be recovered face multidimensional post-covid consequences. This study aimed to describe the aftermath of COVID-19 in relation to social, financial and health related aspects among previously hospitalized patients.\r\n\r\nThis descriptive qualitative study includes participants (n = 14) who were previously hospitalized for COVID-19 and returned home after recovery. The participants were part of a mixed method study from which they were purposively selected. Semi-structured in-depth interviews were conducted over telephone. Inductive content analysis was used to analyze the data.\r\n\r\nTwelve sub-categories emerged from the data analysis which converged into five main categories. The main categories included perspective on physical health, financial struggle, life adjustment, interplay between different domains, and spontaneous support.\r\n\r\nThe lived experiences of COVID-19 recovered patients highlighted multidimensional impact on their daily lives. Physical and psychological wellbeing found to be related to the effort of restoring financial status. People's perception about life altered due to pandemic, for few the pandemic was an opportunity to grow while others found it difficult to accept the hardship. Such multidimensional post COVID-19 impact on people's lives and wellbeing holds considerable implication for response and mitigation plan for future related pandemics.", "doi": "10.3389/fpubh.2023.1196810", "pmid": "37397755", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10311015"}], "notes": [], "created": "2023-10-04T12:08:58.334Z", "modified": "2023-10-04T12:45:46.487Z"}, {"entity": "publication", "iuid": "d881e0269eb546b5b9f6e7afe681a3ea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d881e0269eb546b5b9f6e7afe681a3ea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d881e0269eb546b5b9f6e7afe681a3ea"}}, "title": "Effects of the COVID-19 pandemic on mental health, working, and life situation of employees in the Swedish hospitality industry.", "authors": [{"family": "Feltmann", "given": "Kristin", "initials": "K"}, {"family": "Gustafsson", "given": "Nina-Katri J", "initials": "NJ"}, {"family": "Elg\u00e1n", "given": "Tobias H", "initials": "TH"}, {"family": "Gripenberg", "given": "Johanna", "initials": "J"}, {"family": "Kvillemo", "given": "Pia", "initials": "P"}], "type": "journal article", "published": "2023-06-14", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "1178847"}, "abstract": "Previous studies reported that the coronavirus disease (COVID-19) pandemic has negatively affected the mental health of employees in the hospitality industry internationally, however, its effect in Sweden has not been studied. Unlike several other countries, Sweden never enforced a lockdown. Restaurants, bars, and hotels could remain open and host a limited number of guests but had to abide by certain restrictions.\r\n\r\nA cross-sectional survey was distributed among hospitality industry employees containing questions regarding the perceived effects of the pandemic on the respondents' working and life situations and their physical and psychological health. The sample consisted of 699 individuals, with a response rate of 47.9%.\r\n\r\nAlthough several respondents had been laid off or furloughed, the majority of the sample remained at the same employer. However, more than half of the respondents reported that their economic situation had deteriorated. Compared to before the pandemic, 38.1% experienced elevated levels of stress, 48.3% experienced elevated levels of worry, and 31.4% reported worsened mood. A deteriorating personal economy and difficulty in following COVID-19-related restrictions at work were associated with the worsening of these three mental health aspects. While the fear of becoming infected with COVID-19 was related to higher levels of stress, the fear of infecting others was related to higher levels of worry.\r\n\r\nAlthough Sweden imposed less strict measures than most other countries, the personal economy and mental health of hospitality workers were negatively affected by the COVID-19 pandemic.", "doi": "10.3389/fpubh.2023.1178847", "pmid": "37388155", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10303113"}], "notes": [], "created": "2023-10-04T09:31:14.241Z", "modified": "2023-10-04T10:46:13.914Z"}, {"entity": "publication", "iuid": "35e61dc5b20249189443661e0e8d32db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/35e61dc5b20249189443661e0e8d32db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/35e61dc5b20249189443661e0e8d32db"}}, "title": "Disrupting the opportunity narrative: navigating transformation in times of uncertainty and crisis.", "authors": [{"family": "Moore", "given": "Michele-Lee", "initials": "M"}, {"family": "Hermanus", "given": "Lauren", "initials": "L"}, {"family": "Drimie", "given": "Scott", "initials": "S"}, {"family": "Rose", "given": "Loretta", "initials": "L"}, {"family": "Mbaligontsi", "given": "Mandisa", "initials": "M"}, {"family": "Musarurwa", "given": "Hillary", "initials": "H"}, {"family": "Ogutu", "given": "Moses", "initials": "M"}, {"family": "Oyowe", "given": "Khanyisa", "initials": "K"}, {"family": "Olsson", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2023-06-14", "journal": {"title": "Sustain Sci", "issn": "1862-4057", "issn-l": null, "volume": null, "issue": null, "pages": "1-17"}, "abstract": "COVID-19 posed threats for health and well-being directly, but it also revealed and exacerbated social-ecological inequalities, worsening hunger and poverty for millions. For those focused on transforming complex and problematic system dynamics, the question was whether such devastation could create a formative moment in which transformative change could become possible. Our study examines the experiences of change agents in six African countries engaged in efforts to create or support transformative change processes. To better understand the relationship between crisis, agency, and transformation, we explored how they navigated their changed conditions and the responses to COVID-19. We document three impacts: economic impacts, hunger, and gender-based violence and we examine how they (re)shaped the opportunity contexts for change. Finally, we identify four kinds of uncertainties that emerged as a result of policy responses, including uncertainty about the: (1) robustness of preparing a system to sustain a transformative trajectory, (2) sequencing and scaling of changes within and across systems, (3) hesitancy and exhaustion effects, and (4) long-term effects of surveillance, and we describe the associated change agent strategies. We suggest these uncertainties represent new theoretical ground for future transformations research.\r\n\r\nThe online version contains supplementary material available at 10.1007/s11625-023-01340-1.", "doi": "10.1007/s11625-023-01340-1", "pmid": "37363311", "labels": {"Category: Social Science & Humanities": null, "Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10265562"}, {"db": "pii", "key": "1340"}], "notes": [], "created": "2023-10-04T09:32:21.466Z", "modified": "2023-10-04T11:05:44.341Z"}, {"entity": "publication", "iuid": "6bfd31e9905e445fac42bbb935e9d426", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6bfd31e9905e445fac42bbb935e9d426.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6bfd31e9905e445fac42bbb935e9d426"}}, "title": "Behavioral responses of terrestrial mammals to COVID-19 lockdowns.", "authors": [{"family": "Tucker", "given": "Marlee A", "initials": "MA", "orcid": "0000-0001-7535-3431", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39e654d94797463893f3590bb779d056.json"}}, {"family": "Schipper", "given": "Aafke M", "initials": "AM", "orcid": "0000-0002-5667-0893", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68a75c2ed9924c70897ac6947592c335.json"}}, {"family": "Adams", "given": "Tempe S F", "initials": "TSF"}, {"family": "Attias", "given": "Nina", "initials": "N", "orcid": "0000-0002-9472-6763", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f703ab61b3364654b989cbcc3ed99ce2.json"}}, {"family": "Avgar", "given": "Tal", "initials": "T", "orcid": "0000-0002-8764-6976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8428fb8febb44f49f6cd4abbe4bd61f.json"}}, {"family": "Babic", "given": "Natarsha L", "initials": "NL", "orcid": "0000-0001-6813-9728", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c49b0167d18344f9802d241103a8fa72.json"}}, {"family": "Barker", "given": "Kristin J", "initials": "KJ", "orcid": "0000-0002-1618-7610", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bea5c2a78de34997ab5af9c72359b8ef.json"}}, {"family": "Bastille-Rousseau", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-6799-639X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f1001971c674ae79e6a0b72d5842310.json"}}, {"family": "Behr", "given": "Dominik M", "initials": "DM", "orcid": "0000-0001-7378-8538", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b035004e8f4048c581b6fe5df098c93f.json"}}, {"family": "Belant", "given": "Jerrold L", "initials": "JL"}, {"family": "Beyer", "given": "Dean E", "initials": "DE"}, {"family": "Blaum", "given": "Niels", "initials": "N", "orcid": "0000-0001-6807-5162", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3550ab0cc47b489bb0dddcac51db8563.json"}}, {"family": "Blount", "given": "J David", "initials": "JD", "orcid": "0000-0003-3208-2947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b6367bd4df5545a5ba9ed2a6a53b8ae9.json"}}, {"family": "Bockm\u00fchl", "given": "Dirk", "initials": "D"}, {"family": "Pires Boulhosa", "given": "Ricardo Luiz", "initials": "RL", "orcid": "0000-0002-1212-7805", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c6aaa32848b482ab3e9b18bfda7900b.json"}}, {"family": "Brown", "given": "Michael B", "initials": "MB", "orcid": "0000-0002-0119-0614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a0d7860afa14b10a1a1862aa39c3cfa.json"}}, {"family": "Buuveibaatar", "given": "Bayarbaatar", "initials": "B", "orcid": "0000-0003-0404-269X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd145213190b4541b84fd34417aba1bc.json"}}, {"family": "Cagnacci", "given": "Francesca", "initials": "F", "orcid": "0000-0002-4954-9980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d05696a8933422b8b9b1cde6acb9ac4.json"}}, {"family": "Calabrese", "given": "Justin M", "initials": "JM", "orcid": "0000-0003-0575-6408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67d44f10243745e680172193412492e6.json"}}, {"family": "\u010cerne", "given": "Rok", "initials": "R"}, {"family": "Chamaill\u00e9-Jammes", "given": "Simon", "initials": "S", "orcid": "0000-0003-0505-6620", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4b1216168fc4acd89859a2f7f684faf.json"}}, {"family": "Chan", "given": "Aung Nyein", "initials": "AN", "orcid": "0000-0003-2706-6969", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc84aeda43b540ca84aa81780998ede3.json"}}, {"family": "Chase", "given": "Michael J", "initials": "MJ"}, {"family": "Chaval", "given": "Yannick", "initials": "Y"}, {"family": "Chenaux-Ibrahim", "given": "Yvette", "initials": "Y", "orcid": "0000-0002-7239-9108", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d264598b4f04e77ba0f6c4c98c9e296.json"}}, {"family": "Cherry", "given": "Seth G", "initials": "SG", "orcid": "0000-0003-4242-3629", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6338b3468954b26a4bb6426e6f34346.json"}}, {"family": "\u0106irovi\u0107", "given": "Du\u0161ko", "initials": "D", "orcid": "0000-0001-9468-0948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0997b4f72b3a4cf9b7aa79f20fc2b94e.json"}}, {"family": "\u00c7oban", "given": "Emrah", "initials": "E", "orcid": "0000-0002-9020-2014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1bdeb742f2c48d689e7a13db719b348.json"}}, {"family": "Cole", "given": "Eric K", "initials": "EK", "orcid": "0000-0002-2229-5853", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56e3c4fab7a24dc282847a7010660ca5.json"}}, {"family": "Conlee", "given": "Laura", "initials": "L"}, {"family": "Courtemanch", "given": "Alyson", "initials": "A", "orcid": "0000-0001-7405-7657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b93b87aca8a4b07bfce2915c7afaca4.json"}}, {"family": "Cozzi", "given": "Gabriele", "initials": "G", "orcid": "0000-0002-1744-1940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/468af7bfd1d84ecf9f093421b6e17125.json"}}, {"family": "Davidson", "given": "Sarah C", "initials": "SC", "orcid": "0000-0002-2766-9201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4104be953f3d4f82829883993dc311ae.json"}}, {"family": "DeBloois", "given": "Darren", "initials": "D", "orcid": "0000-0002-5960-0524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/029508ab21c440c9b8623be18da70807.json"}}, {"family": "Dejid", "given": "Nandintsetseg", "initials": "N", "orcid": "0000-0002-5376-3808", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d78e716ee1849c8bac3885e9ddb70a1.json"}}, {"family": "DeNicola", "given": "Vickie", "initials": "V", "orcid": "0000-0003-3558-2541", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa24a0c2330f4f70859ecc45a8898e49.json"}}, {"family": "Desbiez", "given": "Arnaud L J", "initials": "ALJ", "orcid": "0000-0001-5968-6025", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f83ef1c96e74a208e032b68ee33e5cd.json"}}, {"family": "Douglas-Hamilton", "given": "Iain", "initials": "I", "orcid": "0000-0002-7942-7554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c5c3b38ed2c4109887974d48265babc.json"}}, {"family": "Drake", "given": "David", "initials": "D"}, {"family": "Egan", "given": "Michael", "initials": "M"}, {"family": "Eikelboom", "given": "Jasper A J", "initials": "JAJ", "orcid": "0000-0002-5107-4427", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/783112dcb8fa440a8a7f1dc395436670.json"}}, {"family": "Fagan", "given": "William F", "initials": "WF", "orcid": "0000-0003-2433-9052", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9c9b1c4511b42829a6bdc819f83d2b6.json"}}, {"family": "Farmer", "given": "Morgan J", "initials": "MJ", "orcid": "0000-0002-6320-9587", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7762aff3c005490e9817f6d31f8cc708.json"}}, {"family": "Fennessy", "given": "Julian", "initials": "J", "orcid": "0000-0001-5871-8267", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28050549c3f04a328cba87965d802b01.json"}}, {"family": "Finnegan", "given": "Shannon P", "initials": "SP", "orcid": "0000-0003-3265-9996", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/138a7e1b278441eb84bc1ce3bc0821e3.json"}}, {"family": "Fleming", "given": "Christen H", "initials": "CH", "orcid": "0000-0002-9356-6518", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9119e001684465aaab71a752ab721fb.json"}}, {"family": "Fournier", "given": "Bonnie", "initials": "B"}, {"family": "Fowler", "given": "Nicholas L", "initials": "NL", "orcid": "0000-0003-3977-0945", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b18a5ccfac24095ad4df1d65fd8b7bb.json"}}, {"family": "Gantchoff", "given": "Mariela G", "initials": "MG", "orcid": "0000-0002-7098-8072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42810228f6c4465f93b8775e3592a31c.json"}}, {"family": "Garnier", "given": "Alexandre", "initials": "A", "orcid": "0000-0003-3515-8556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc98ff203d0e490394a489f2e31f238b.json"}}, {"family": "Gehr", "given": "Benedikt", "initials": "B", "orcid": "0000-0002-1044-9296", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42fea1cd196a4c72a3e3e78b12e06054.json"}}, {"family": "Geremia", "given": "Chris", "initials": "C"}, {"family": "Goheen", "given": "Jacob R", "initials": "JR", "orcid": "0000-0001-6609-0692", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e21fbd5ccba45ee92e12d568b3ff7fb.json"}}, {"family": "Hauptfleisch", "given": "Morgan L", "initials": "ML", "orcid": "0000-0003-0654-0887", "researcher": {"href": 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"Stewart", "given": "Cheyenne", "initials": "C", "orcid": "0000-0003-3394-1926", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44af4cd029dd44a5b962ef5f0532a610.json"}}, {"family": "Strand", "given": "Olav", "initials": "O"}, {"family": "Sunde", "given": "Peter", "initials": "P", "orcid": "0000-0002-7485-037X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6aeaa45baa1c49be961015b46e902313.json"}}, {"family": "Svoboda", "given": "Nathan J", "initials": "NJ", "orcid": "0000-0002-1939-0569", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81a560acb4194666bd618a4d4d73447a.json"}}, {"family": "Swart", "given": "Jonathan", "initials": "J"}, {"family": "Thompson", "given": "Jeffrey J", "initials": "JJ", "orcid": "0000-0002-5632-1466", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a51bc818b4874660ba0ef67ab54e0312.json"}}, {"family": "Toal", "given": "Katrina L", "initials": "KL"}, {"family": "Uiseb", "given": "Kenneth", "initials": "K", "orcid": "0000-0002-5284-9917", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/16d9082540ad420390d2d9ffd6387c14.json"}}, {"family": "VanAcker", "given": "Meredith C", "initials": "MC", "orcid": "0000-0002-5690-9139", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80932eb728274c65aad725e335addd82.json"}}, {"family": "Velilla", "given": "Marianela", "initials": "M", "orcid": "0000-0002-4212-885X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73a5e56198c746428c55e6eb008ba0a7.json"}}, {"family": "Verzuh", "given": "Tana L", "initials": "TL", "orcid": "0000-0003-4027-5415", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2758992cbdfb413cbd74a836ed38c0bc.json"}}, {"family": "Wachter", "given": "Bettina", "initials": "B", "orcid": "0000-0002-0414-2298", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa93e479797847b7aa92596fa42abca3.json"}}, {"family": "Wagler", "given": "Brittany L", "initials": "BL", "orcid": "0000-0001-9526-820X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b18fb21a5f64401da1c860eac6b18e7e.json"}}, {"family": "Whittington", "given": "Jesse", "initials": "J", "orcid": "0000-0002-4129-7491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1fd61d870e474140acfa1a4c94f7d6a6.json"}}, {"family": "Wikelski", "given": "Martin", "initials": "M", "orcid": "0000-0002-9790-7025", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c024723549c485886b238320b8d2df5.json"}}, {"family": "Wilmers", "given": "Christopher C", "initials": "CC", "orcid": "0000-0003-2063-1478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7bbb1a449b9c47c1ba23cbe52421f41d.json"}}, {"family": "Wittemyer", "given": "George", "initials": "G", "orcid": "0000-0003-1640-5355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a34151a7cae947678b526d0729dfb35b.json"}}, {"family": "Young", "given": "Julie K", "initials": "JK", "orcid": "0000-0003-4522-0157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/978312c400d244298994c1ff848de78b.json"}}, {"family": "Zi\u0119ba", "given": "Filip", "initials": "F"}, {"family": "Zwijacz-Kozica", "given": "Tomasz", "initials": "T", "orcid": "0000-0002-7488-975X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a7eb67e79544a04b42db4c701fb9966.json"}}, {"family": "Huijbregts", "given": "Mark A J", "initials": "MAJ", "orcid": "0000-0002-7037-680X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/292dab5a2730421f806d017d8c048708.json"}}, {"family": "Mueller", "given": "Thomas", "initials": "T", "orcid": "0000-0001-9305-7716", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a8409fac8db41ca8b1ae9b4bd129a8a.json"}}], "type": "journal article", "published": "2023-06-09", "journal": {"title": "Science", "issn": "1095-9203", "issn-l": "0036-8075", "volume": "380", "issue": "6649", "pages": "1059-1064"}, "abstract": "COVID-19 lockdowns in early 2020 reduced human mobility, providing an opportunity to disentangle its effects on animals from those of landscape modifications. Using GPS data, we compared movements and road avoidance of 2300 terrestrial mammals (43 species) during the lockdowns to the same period in 2019. Individual responses were variable with no change in average movements or road avoidance behavior, likely due to variable lockdown conditions. However, under strict lockdowns 10-day 95th percentile displacements increased by 73%, suggesting increased landscape permeability. Animals' 1-hour 95th percentile displacements declined by 12% and animals were 36% closer to roads in areas of high human footprint, indicating reduced avoidance during lockdowns. Overall, lockdowns rapidly altered some spatial behaviors, highlighting variable but substantial impacts of human mobility on wildlife worldwide.", "doi": "10.1126/science.abo6499", "pmid": "37289888", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:32:57.916Z", "modified": "2023-10-04T11:15:23.800Z"}, {"entity": "publication", "iuid": "2e7edc9ebbdc404690076ca003d8d320", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e7edc9ebbdc404690076ca003d8d320.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e7edc9ebbdc404690076ca003d8d320"}}, "title": "Challenges in preserving the \"good doctor\" norm: physicians' discourses on changes to the medical logic during the initial wave of the COVID-19 pandemic.", "authors": [{"family": "H\u00e4rgestam", "given": "Maria", "initials": "M"}, {"family": "Jacobsson", "given": "Maritha", "initials": "M"}, {"family": "B\u00e5\u00e5the", "given": "Fredrik", "initials": "F"}, {"family": "Brulin", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2023-06-08", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "14", "issue": null, "pages": "1083047"}, "abstract": "The COVID-19 pandemic was a tremendous challenge to the practice of modern medicine. In this study, we use neo-institutional theory to gain an in-depth understanding of how physicians in Sweden narrate how they position themselves as physicians when practicing modern medicine during the first wave of the pandemic. At focus is medical logic, which integrates rules and routines based on medical evidence, practical experience, and patient perspectives in clinical decision-making.\r\n\r\nTo understand how physicians construct their versions of the pandemic and how it impacted the medical logic in which they practice, we analyzed the interviews from 28 physicians in Sweden by discursive psychology.\r\n\r\nThe interpretative repertoires showed how COVID-19 created an experience of knowledge vacuum in medical logic and how physicians dealt with clinical patient dilemmas. They had to find unorthodox ways to rebuild a sense of medical evidence while still being responsible for clinical decision-making for patients with critical care needs.\r\n\r\nIn the knowledge vacuum occurring during the first wave of COVID-19, physicians could not use their common medical knowledge nor rely on published evidence or their clinical judgment. They were thus challenged in their norm of being the \"good doctor\". One practical implication of this research is that it provides a rich empirical account where physicians are allowed to mirror, make sense, and normalize their own individual and sometimes painful struggle to uphold the professional role and related medical responsibility in the early phases of the COVID-19 pandemic. It will be important to follow how the tremendous challenge of COVID-19 to medical logic plays out over time in the community of physicians. There are many dimensions to study, with sick leave, burnout, and attrition being some interesting areas.", "doi": "10.3389/fpsyg.2023.1083047", "pmid": "37359864", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Funder: Forte": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10285475"}], "notes": [], "created": "2023-10-04T09:31:01.174Z", "modified": "2023-10-04T10:40:57.789Z"}, {"entity": "publication", "iuid": "197891042362460798eb43322d0e99aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/197891042362460798eb43322d0e99aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/197891042362460798eb43322d0e99aa"}}, "title": "The increasing age of respiratory syncytial virus-related hospitalisation during COVID-19 pandemic in Lyon was associated with reduced hospitalisation costs.", "authors": [{"family": "Roy", "given": "\u00c1lvaro", "initials": "\u00c1"}, {"family": "Polazzi", "given": "St\u00e9phanie", "initials": "S"}, {"family": "Ploin", "given": "Dominique", "initials": "D"}, {"family": "Gillet", "given": "Yves", "initials": "Y"}, {"family": "Javouhey", "given": "Etienne", "initials": "E"}, {"family": "Lina", "given": "Bruno", "initials": "B"}, {"family": "VRS study group in Lyon", "given": "", "initials": ""}, {"family": "Myard-Dury", "given": "Anne-Florence", "initials": "A"}, {"family": "Couray-Targe", "given": "Sandrine", "initials": "S"}, {"family": "Duclos", "given": "Antoine", "initials": "A"}, {"family": "Casalegno", "given": "Jean-S\u00e9bastien", "initials": "J"}], "type": "journal article", "published": "2023-06-07", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null, "volume": "41", "issue": "25", "pages": "3796-3800"}, "abstract": "Preventive measures applied during the COVID-19 pandemic have modified the age distribution, the clinical severity and the incidence of Respiratory Syncytial Virus (RSV) hospitalisations during the 2020/21 RSV season. The aim of the present study was to estimate the impact of these aspects on RSV-associated hospitalisations (RSVH) costs stratified by age group between pre-COVID-19 seasons and 2020/21 RSV season.\r\n\r\nWe compared the incidence, the median costs, and total RSVH costs from the national health insurance perspective in children < 24 months of age during the COVID-19 period (2020/21 RSV season) with a pre-COVID-19 period (2014/17 RSV seasons). Children were born and hospitalised in the Lyon metropolitan area. RSVH costs were extracted from the French medical information system (Programme de M\u00e9dicalisation des Syst\u00e9mes d'Information).\r\n\r\nThe RSVH-incidence rate per 1000 infants aged < 3 months decreased significantly from 4.6 (95 % CI [4.1; 5.2]) to 3.1 (95 % CI [2.4; 4.0]), and increased in older infants and children up to 24 months of age during the 2020/21 RSV season. Overall, RSVH costs for RSVH cases aged below 2 years old decreased by \u20ac201,770 (31 %) during 2020/21 RSV season compared to the mean pre-COVID-19 costs.\r\n\r\nThe sharp reduction in costs of RSVH in infants aged < 3 months outweighed the modest increase in costs observed in the 3-24 months age group. Therefore, conferring a temporal protection through passive immunisation to infants aged < 3 months should have a major impact on RSVH costs even if it results in an increase of RSVH in older children infected later in life. Nevertheless, stakeholders should be aware of this potential increase of RSVH in older age groups presenting with a wider range of disease to avoid any bias in estimating the cost-effectiveness of passive immunisation strategies.", "doi": "10.1016/j.vaccine.2023.05.021", "pmid": "37198017", "labels": {"Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10169568"}, {"db": "pii", "key": "S0264-410X(23)00548-0"}], "notes": [], "created": "2023-10-04T05:11:05.684Z", "modified": "2023-10-04T07:06:48.858Z"}, {"entity": "publication", "iuid": "71bc203ffa044fe28ec637a7c3070875", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/71bc203ffa044fe28ec637a7c3070875.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/71bc203ffa044fe28ec637a7c3070875"}}, "title": "Hindering and enabling factors for young employees with common mental disorder to remain at or return to work affected by the Covid-19 pandemic - a qualitative interview study with young employees and managers.", "authors": [{"family": "Wallberg", "given": "Martina", "initials": "M", "orcid": "0000-0002-8881-1822", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9349fb21e752467c85bd602c36510a91.json"}}, {"family": "Tinnerholm Ljungberg", "given": "Helena", "initials": "H"}, {"family": "Bj\u00f6rk Br\u00e4mberg", "given": "Elisabeth", "initials": "E"}, {"family": "Nybergh", "given": "Lotta", "initials": "L"}, {"family": "Jensen", "given": "Irene", "initials": "I"}, {"family": "Olsson", "given": "Caroline", "initials": "C", "orcid": "0000-0001-7561-2480", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/38563e81bb7d4ec794d7798fed320161.json"}}], "type": "journal article", "published": "2023-06-07", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "6", "pages": "e0286819"}, "abstract": "During the COVID-19 pandemic, changes in working life occurred, even in Sweden, where there was no general lockdown. The aim of this study was to examine how the COVID-19 pandemic was perceived as affecting the hindering and enabling factors among young employees with CMD to remain at or return to work, here as investigated from the perspective of young employees and managers.\r\n\r\nA qualitative design was applied with semistructured interviews with 23 managers and 25 young employees (20-29 years old). The interviews were recorded and transcribed verbatim, and the parts of the interviews related to the aim of this article were analysed using conventional content analysis.\r\n\r\nThe hindering factors were changed working conditions, decreased well-being when spending more time at home, and uncertainty. The enabling factors were decreased demands, increased balance, and well-functioning work processes. For managers it is important to be aware of warning signals indicating blurred boundaries between work and private life, to create and maintain well-functioning communication, and leave room for recovery.\r\n\r\nThe hindering and enabling factors can be described as two sides of the same coin. Changes in the working conditions during the pandemic led to difficulties for both young employees and managers when the margins of maneuver were insufficient.", "doi": "10.1371/journal.pone.0286819", "pmid": "37285347", "labels": {"Category: Social Science & Humanities": null, "Funder: Forte": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10246792"}, {"db": "pii", "key": "PONE-D-22-17806"}], "notes": [], "created": "2023-10-04T09:31:53.412Z", "modified": "2023-10-04T10:57:11.810Z"}, {"entity": "publication", "iuid": "34746c67d2384baa9e428ac6d9b6ad2c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/34746c67d2384baa9e428ac6d9b6ad2c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/34746c67d2384baa9e428ac6d9b6ad2c"}}, "title": "COVID-19 hospitalization outcomes in adults by HIV status; a nation-wide register-based study.", "authors": [{"family": "M\u00f6ller", "given": "Isabela Killander", "initials": "IK", "orcid": "0000-0002-4105-2902", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3278886cd2af47229149a55443b38f09.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Wagner", "given": "Philippe", "initials": "P"}, {"family": "Spar\u00e9n", "given": "P\u00e4r", "initials": "P"}, {"family": "Carlander", "given": "Christina", "initials": "C", "orcid": "0000-0001-9962-5964", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b819f761acf34fdea8f11d0743a5b86c.json"}}], "type": "journal article", "published": "2023-06-07", "journal": {"title": "HIV Med", "issn": "1468-1293", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To assess the outcome of patients hospitalized with COVID-19 by HIV status and risk factors for severe COVID-19 in people living with HIV (PWH), we performed a nationwide cohort study using register data.\r\n\r\nAll people aged \u226518 years hospitalized with a primary COVID-19 diagnosis (U07.1 or U07.2) in Sweden between February 2020 and October 2021 were included. The primary outcome was severe COVID-19 [intensive care unit (ICU) admission or 90-day mortality]. Secondary outcomes were days in hospital and ICU, complications in hospital, and risk factors for severe COVID-19 in PWH. Regression analyses were performed to assess severe COVID-19 by HIV status and risk factors.\r\n\r\nData from 64 815 hospitalized patients were collected, of whom 121 were PWH (0.18%). PWH were younger (p < 0.001), and larger proportions were men (p = 0.014) and migrants (p < 0.001). Almost all PWH had undetectable HIV-RNA (93%) and high CD4 T-cell counts (median = 560 cells/\u03bcL, interquartile range: 376-780). In an unadjusted model, PWH had statistically significant lower odds of severe COVID-19 compared with patients without HIV [odds ratio (OR) = 0.6, 95% confidence interval (CI): 0.34-0.94], but there was no significant difference after adjusting for age and comorbidity (adjusted OR = 0.7, 95% CI: 0.43-1.26). A statistically significant lower proportion of PWH (8%, 95% CI: 5-15%) died within 90 days compared with those without HIV (16%, 95% CI: 15-16%, p = 0.024). There was no statistically significant difference in days in hospital and complications during the hospital stay between PWH and patients without HIV.\r\n\r\nIn this nationwide study including well-treated PWH, HIV was not a risk factor in hospitalized patients for developing severe COVID-19.", "doi": "10.1111/hiv.13515", "pmid": "37286199", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:30:33.798Z", "modified": "2023-10-04T09:58:23.498Z"}, {"entity": "publication", "iuid": "f12410c233584d12a1290f24ac6cac03", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f12410c233584d12a1290f24ac6cac03.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f12410c233584d12a1290f24ac6cac03"}}, "title": "Functional Foods: A Promising Strategy for Restoring Gut Microbiota Diversity Impacted by SARS-CoV-2 Variants.", "authors": [{"family": "Banerjee", "given": "Antara", "initials": "A"}, {"family": "Somasundaram", "given": "Indumathi", "initials": "I"}, {"family": "Das", "given": "Diptimayee", "initials": "D"}, {"family": "Jain Manoj", "given": "Samatha", "initials": "S"}, {"family": "Banu", "given": "Husaina", "initials": "H"}, {"family": "Mitta Suresh", "given": "Pavane", "initials": "P"}, {"family": "Paul", "given": "Sujay", "initials": "S", "orcid": "0000-0001-5024-7261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1c15a587da6470ea73c6e3c29a4ba6b.json"}}, {"family": "Bisgin", "given": "Atil", "initials": "A", "orcid": "0000-0002-2053-9076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13bfbc623c634b269c7c69fbb303254d.json"}}, {"family": "Zhang", "given": "Hong", "initials": "H", "orcid": "0000-0003-1834-1578", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/85be136845f6469c946e000f38f18f28.json"}}, {"family": "Sun", "given": "Xiao-Feng", "initials": "X"}, {"family": "Duttaroy", "given": "Asim K", "initials": "AK", "orcid": "0000-0003-1619-3778", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/464702978fa64a368987901580720fe8.json"}}, {"family": "Pathak", "given": "Surajit", "initials": "S", "orcid": "0000-0002-7306-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2cfa7af2c5c549cc82d6f407b1e1e56b.json"}}], "type": "journal article", "published": "2023-06-05", "journal": {"title": "Nutrients", "issn": "2072-6643", "issn-l": null, "volume": "15", "issue": "11", "pages": null}, "abstract": "Natural herbs and functional foods contain bioactive molecules capable of augmenting the immune system and mediating anti-viral functions. Functional foods, such as prebiotics, probiotics, and dietary fibers, have been shown to have positive effects on gut microbiota diversity and immune function. The use of functional foods has been linked to enhanced immunity, regeneration, improved cognitive function, maintenance of gut microbiota, and significant improvement in overall health. The gut microbiota plays a critical role in maintaining overall health and immune function, and disruptions to its balance have been linked to various health problems. SARS-CoV-2 infection has been shown to affect gut microbiota diversity, and the emergence of variants poses new challenges to combat the virus. SARS-CoV-2 recognizes and infects human cells through ACE2 receptors prevalent in lung and gut epithelial cells. Humans are prone to SARS-CoV-2 infection because their respiratory and gastrointestinal tracts are rich in microbial diversity and contain high levels of ACE2 and TMPRSS2. This review article explores the potential use of functional foods in mitigating the impact of SARS-CoV-2 variants on gut microbiota diversity, and the potential use of functional foods as a strategy to combat these effects.", "doi": "10.3390/nu15112631", "pmid": "37299594", "labels": {"Category: Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC10255361"}, {"db": "pii", "key": "nu15112631"}], "notes": [], "created": "2023-10-04T09:32:23.905Z", "modified": "2023-10-04T11:06:54.692Z"}, {"entity": "publication", "iuid": "e0284c17d08b406b99333dcc60d91f37", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e0284c17d08b406b99333dcc60d91f37.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e0284c17d08b406b99333dcc60d91f37"}}, "title": "Coronavirus disease 2019 and gastrointestinal disorders in children.", "authors": [{"family": "R\u00f6ckert Tjernberg", "given": "Anna", "initials": "A", "orcid": "0000-0001-8126-9738", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14df79dd609a4ec1baa8dfda5d7826c7.json"}}, {"family": "Malmborg", "given": "Petter", "initials": "P"}, {"family": "M\u00e5rild", "given": "Karl", "initials": "K"}], "type": "journal article", "published": "2023-06-05", "journal": {"title": "Therap Adv Gastroenterol", "issn": "1756-283X", "issn-l": null, "volume": "16", "issue": null, "pages": "17562848231177612"}, "abstract": "During the past 3 years, the coronavirus disease 2019 (COVID-19) pandemic has had a great impact on people all over the world. However, it has become evident that disease manifestations and severity differ across age groups. Most children have a milder disease course than adults but possibly more pronounced gastrointestinal (GI) symptoms. Given the child's developing immune system, the impact of COVID-19 on disease development may differ compared to adults. This study reviews the potential bi-directional relationship between COVID-19 and GI diseases in children, focusing on common pediatric conditions such as functional GI disorders (FGID), celiac disease (CeD), and inflammatory bowel disease (IBD). Children with GI diseases, in general, and CeD and IBD, in particular, do not seem to have an increased risk of severe COVID-19, including risks of hospitalization, critical care need, and death. While infections are considered candidate environmental factors in both CeD and IBD pathogenesis, and specific infectious agents are known triggers for FGID, there is still not sufficient evidence to implicate COVID-19 in the development of either of these diseases. However, given the scarcity of data and the possible latency period between environmental triggers and disease development, future investigations in this field are warranted.", "doi": "10.1177/17562848231177612", "pmid": "37305380", "labels": {"Category: Health": null, "Funder: VR": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10243097"}, {"db": "pii", "key": "10.1177_17562848231177612"}], "notes": [], "created": "2023-10-04T09:30:39.172Z", "modified": "2023-10-04T10:00:22.818Z"}, {"entity": "publication", "iuid": "b681fae3e4244f0481cfe1fcd6f88761", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b681fae3e4244f0481cfe1fcd6f88761.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b681fae3e4244f0481cfe1fcd6f88761"}}, "title": "Psychiatric and non-psychiatric population vulnerabilities in time of a crisis: the unsuspected aggression factor.", "authors": [{"family": "Martin", "given": "Sylvia", "initials": "S"}, {"family": "Oltra", "given": "Anna", "initials": "A"}, {"family": "Del Monte", "given": "Jonathan", "initials": "J"}], "type": "journal article", "published": "2023-06-01", "journal": {"title": "BMC Psychiatry", "issn": "1471-244X", "issn-l": null, "volume": "23", "issue": "1", "pages": "386"}, "abstract": "In March 2020, France faced a health crisis due to the COVID-19 outbreak that, like previous infectious disease crises, involved high psychological and emotional stress, a series of factors that influenced the ongoing mental health crisis.\r\n\r\nWe recruited 384 respondents to complete an online questionnaire during the second month of isolation: 176 psychotherapy recipients (68 were currently attending psychiatric care) and 208 healthy controls. We measured demographic characteristics, impulsivity, aggression, hopelessness, suicidal risk, and the global level of anxiety and depression in order to estimate potential discrepancies in clinical measures across these populations.\r\n\r\nOur results indicate that the group currently undergoing psychiatric care was prone to loneliness and social isolation. Regarding clinical and nonclinical population, there were differences in suicidal risk, depression, anxiety, and hopelessness but mainly in aggression. Regression analysis also demonstrated that aggression surprisingly influenced anxiety levels. Patients undergoing therapy compared with patients who were not displayed differences only in suicidal risk, anxiety, and hopelessness, with those undergoing therapy having higher scores. The outpatient group undergoing therapy had a significantly lower level of impulsivity. Moreover, the regression to predict anxiety and depression levels from correlated factors highlighted the potentially heightened role of aggression in predicting anxiety in the clinical group.\r\n\r\nNew research into stress reactions should assess other clinical signals, such as aggression, and examine preventive mental health interventions in times of crisis.", "doi": "10.1186/s12888-023-04843-4", "pmid": "37264352", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10234249"}, {"db": "pii", "key": "10.1186/s12888-023-04843-4"}], "notes": [], "created": "2023-10-04T09:32:55.523Z", "modified": "2023-10-04T11:14:18.576Z"}, {"entity": "publication", "iuid": "41efdcff61bd4f449f244b6fd78cd47a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41efdcff61bd4f449f244b6fd78cd47a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41efdcff61bd4f449f244b6fd78cd47a"}}, "title": "Assessing the availability and quality of COVID-19 mortality data in Europe: a comparative analysis.", "authors": [{"family": "Marinkovi\u0107", "given": "Ivan", "initials": "I"}, {"family": "Tramo\u0161ljanin", "given": "Ana", "initials": "A"}, {"family": "Galjak", "given": "Marko", "initials": "M", "orcid": "0000-0002-1756-3083", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13cc17cd42d04f39a19c9c844b825f12.json"}}], "type": "journal article", "published": "2023-06-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": null, "issue": null, "pages": null}, "abstract": "Researching mortality during the COVID-19 pandemic has been challenging due to methodological inconsistencies and the limited availability of vital statistics data. At the beginning of the pandemic, the World Health Organization recommended daily data publication to inform policy response, but these data were often poor. Final data on COVID-19 deaths in many countries are not yet available, especially for 2021. This report shows that many countries have significant inconsistencies between the preliminary number of deaths and what vital statistics and excess mortality indicate. The inconsistencies in the mortality data raise concerns about the reliability of analyses and public health recommendations.", "doi": "10.1093/eurpub/ckad088", "pmid": "37263603", "labels": {"Category: Other": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7188269"}], "notes": [], "created": "2023-10-04T09:31:16.503Z", "modified": "2023-10-04T10:47:07.312Z"}, {"entity": "publication", "iuid": "adc405a737f54f5b931af68fc3b891ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/adc405a737f54f5b931af68fc3b891ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/adc405a737f54f5b931af68fc3b891ae"}}, "title": "Age and sex differences in cause-specific excess mortality and years of life lost associated with COVID-19 infection in the Swedish population.", "authors": [{"family": "Lundberg", "given": "Christina E", "initials": "CE", "orcid": "0000-0002-9062-9982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8800d9296bee40f9b178e8ab8399a993.json"}}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}, {"family": "Brand\u00e9n", "given": "Maria", "initials": "M"}, {"family": "Cronie", "given": "Ottmar", "initials": "O"}, {"family": "Lindgren", "given": "Martin", "initials": "M"}, {"family": "Edqvist", "given": "Jon", "initials": "J"}, {"family": "\u00c5berg", "given": "Maria", "initials": "M"}, {"family": "Adiels", "given": "Martin", "initials": "M"}, {"family": "Rosengren", "given": "Annika", "initials": "A", "orcid": "0000-0002-5409-6605", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9cd943e45dd14e14b5367c0ad1a2b950.json"}}], "type": "journal article", "published": "2023-06-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": null, "issue": null, "pages": null}, "abstract": "Estimating excess mortality and years of life lost (YLL) attributed to coronavirus disease 19 (COVID-19) infection provides a comprehensive picture of the mortality burden on society. We aimed to estimate the impact of the COVID-19 pandemic on age- and sex-specific excess mortality and YLL in Sweden during the first 17 months of the pandemic.\r\n\r\nIn this population-based observational study, we calculated age- and sex-specific excess all-cause mortality and excess YLL during 2020 and the first 5 months of 2021 and cause-specific death [deaths from cardiovascular disease (CVD), cancer, other causes and deaths excluding COVID-19] in 2020 compared with an average baseline for 2017-19 in the whole Swedish population.\r\n\r\nCOVID-19 deaths contributed 9.9% of total deaths (98 441 deaths, 960 305 YLL) in 2020, accounting for 75 151 YLL (7.7 YLL/death). There were 2672 (5.7%) and 1408 (3.0%) excess deaths, and 19 141 (3.8%) and 3596 (0.8%) excess YLL in men and women, respectively. Men aged 65-110 years and women aged 75-110 years were the greatest contributors. Fewer deaths and YLL from CVD, cancer and other causes were observed in 2020 compared with the baseline adjusted to the population size in 2020.\r\n\r\nCompared with the baseline, excess mortality and YLL from all causes were experienced in Sweden during 2020, with a higher excess observed in men than in women, indicating that more men died at a younger age while more women died at older ages than expected. A notable reduction in deaths and YLL due to CVD suggests a displacement effect from CVD to COVID-19.", "doi": "10.1093/eurpub/ckad086", "pmid": "37263601", "labels": {"Category: Health": null, "Funder: VR": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7188268"}], "notes": [], "created": "2023-10-04T09:30:43.855Z", "modified": "2023-10-04T10:02:39.508Z"}, {"entity": "publication", "iuid": "c45d86d4b8694925aaa296723ab7423f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c45d86d4b8694925aaa296723ab7423f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c45d86d4b8694925aaa296723ab7423f"}}, "title": "The macroeconomics of pandemics around the world: Lives versus livelihoods revisited.", "authors": [{"family": "Alm\u00e5s", "given": "Ingvild", "initials": "I"}, {"family": "Bold", "given": "Tessa", "initials": "T"}, {"family": "von Carnap", "given": "Tillmann", "initials": "T"}, {"family": "Ghisolfi", "given": "Selene", "initials": "S"}, {"family": "Sandefur", "given": "Justin", "initials": "J"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "J Dev Econ", "issn": "0304-3878", "issn-l": null, "volume": "163", "issue": null, "pages": "103099"}, "abstract": "The COVID-19 pandemic led governments around the world to impose unprecedented restrictions on economic activity. Were these restrictions equally justified in poorer countries with fewer demographic risk factors and less ability to weather economic shocks? We develop and estimate a fully specified model of the macroeconomy with epidemiological dynamics, incorporating subsistence constraints in consumption and allowing preferences over \"lives versus livelihoods\" to vary with income. Poorer countries' demography pushes them unambiguously toward laxer policies. But because both infected and susceptible agents near the subsistence constraint will remain economically active in the face of infection risk and even to some extent under government containment policies, optimal policy in poorer countries pushes in the opposite direction. Moreover, for reasonable income-elasticities of the value of a statistical life, the model can fully rationalize equally strict or stricter policies in poorer countries.", "doi": "10.1016/j.jdeveco.2023.103099", "pmid": "37151749", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10102539"}, {"db": "pii", "key": "S0304-3878(23)00054-8"}], "notes": [], "created": "2023-10-04T05:12:09.277Z", "modified": "2023-10-04T07:30:00.817Z"}, {"entity": "publication", "iuid": "3b523ea9895b42db95bb6286ef80952b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b523ea9895b42db95bb6286ef80952b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b523ea9895b42db95bb6286ef80952b"}}, "title": "The IHI Rochester Report 2022 on Healthcare Informatics Research: Resuming After the CoViD-19.", "authors": [{"family": "Combi", "given": "Carlo", "initials": "C"}, {"family": "Facelli", "given": "Julio C", "initials": "JC"}, {"family": "Haddawy", "given": "Peter", "initials": "P"}, {"family": "Holmes", "given": "John H", "initials": "JH"}, {"family": "Koch", "given": "Sabine", "initials": "S"}, {"family": "Liu", "given": "Hongfang", "initials": "H"}, {"family": "Meyer", "given": "Jochen", "initials": "J"}, {"family": "Peleg", "given": "Mor", "initials": "M"}, {"family": "Pozzi", "given": "Giuseppe", "initials": "G"}, {"family": "Stiglic", "given": "Gregor", "initials": "G"}, {"family": "Veltri", "given": "Pierangelo", "initials": "P"}, {"family": "Yang", "given": "Christopher C", "initials": "CC"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "J Healthc Inform Res", "issn": "2509-4971", "issn-l": null, "volume": "7", "issue": "2", "pages": "169-202"}, "abstract": "In 2020, the CoViD-19 pandemic spread worldwide in an unexpected way and suddenly modified many life issues, including social habits, social relationships, teaching modalities, and more. Such changes were also observable in many different healthcare and medical contexts. Moreover, the CoViD-19 pandemic acted as a stress test for many research endeavors, and revealed some limitations, especially in contexts where research results had an immediate impact on the social and healthcare habits of millions of people. As a result, the research community is called to perform a deep analysis of the steps already taken, and to re-think steps for the near and far future to capitalize on the lessons learned due to the pandemic. In this direction, on June 09th-11th, 2022, a group of twelve healthcare informatics researchers met in Rochester, MN, USA. This meeting was initiated by the Institute for Healthcare Informatics-IHI, and hosted by the Mayo Clinic. The goal of the meeting was to discuss and propose a research agenda for biomedical and health informatics for the next decade, in light of the changes and the lessons learned from the CoViD-19 pandemic. This article reports the main topics discussed and the conclusions reached. The intended readers of this paper, besides the biomedical and health informatics research community, are all those stakeholders in academia, industry, and government, who could benefit from the new research findings in biomedical and health informatics research. Indeed, research directions and social and policy implications are the main focus of the research agenda we propose, according to three levels: the care of individuals, the healthcare system view, and the population view.", "doi": "10.1007/s41666-023-00126-5", "pmid": "37359193", "labels": {"Funder: H2020": null, "Type: Other": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10150351"}, {"db": "pii", "key": "126"}], "notes": [], "created": "2023-10-04T09:32:16.624Z", "modified": "2023-10-04T11:01:01.548Z"}, {"entity": "publication", "iuid": "caa0cd6c9f3c41b49d6c8db447f9de06", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/caa0cd6c9f3c41b49d6c8db447f9de06.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/caa0cd6c9f3c41b49d6c8db447f9de06"}}, "title": "New urban habits in Stockholm following COVID-19.", "authors": [{"family": "Legeby", "given": "Ann", "initials": "A", "orcid": "0000-0002-3173-853X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cbe1819ded8340b7a9712da118ce8c12.json"}}, {"family": "Koch", "given": "Daniel", "initials": "D"}, {"family": "Duarte", "given": "F\u00e1bio", "initials": "F", "orcid": "0000-0003-0909-5379", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/527c769b3b2143e99e126eb2af7ecd4e.json"}}, {"family": "Heine", "given": "Cate", "initials": "C"}, {"family": "Benson", "given": "Tom", "initials": "T"}, {"family": "Fugiglando", "given": "Umberto", "initials": "U", "orcid": "0000-0001-6527-8968", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05008e7f430d4dccbe1e060d65ba9178.json"}}, {"family": "Ratti", "given": "Carlo", "initials": "C"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Urban Stud", "issn": "0042-0980", "issn-l": null, "volume": "60", "issue": "8", "pages": "1448-1464"}, "abstract": "During the COVID-19 pandemic, physical distancing, mobility restrictions and self-isolation measures were implemented around the world as the primary intervention to prevent the virus from spreading. Urban life has undergone sweeping changes, with people using spaces in new ways. Stockholm is a particularly relevant case of this phenomenon since most facilities, such as day care centres and schools, have remained open, in contrast to cities with a broader lockdown. In this study, we use Twitter data and an online map survey to study how COVID-19 restrictions have impacted the use of different locations, services and amenities in Stockholm. First, we compare the spatial distribution of 87,000 geolocated tweets pre-COVID-19 and during the COVID-19 pandemic. Second, we analyse 895 survey responses asking people to identify places they 'still visit', 'use more', 'avoid' and self-report reasons for using locations. The survey provides a nuanced understanding of whether and how restrictions have affected people. Service and seclusion were found to be important; therefore, the accessibility of such amenities was analysed, demonstrating how changes in urban habits are related to conditions of the local environment. We find how different parts of the city show different capacities to accommodate new habits and mitigate the effects of restrictions on people's use of urban spaces. In addition to the immediate relevance to COVID-19, this paper thus contributes to understanding how restrictions on movement and gathering, in any situation, expose more profound urban challenges related to segregation and social inequality.", "doi": "10.1177/00420980211070677", "pmid": "37273493", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10230291"}, {"db": "pii", "key": "10.1177_00420980211070677"}], "notes": [], "created": "2023-10-04T09:32:39.460Z", "modified": "2023-10-04T11:12:45.336Z"}, {"entity": "publication", "iuid": "46fc0cdf480a4887a1989d1e245cf463", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46fc0cdf480a4887a1989d1e245cf463.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46fc0cdf480a4887a1989d1e245cf463"}}, "title": "Job loss and job instability during the COVID-19 pandemic and the risk of depression and anxiety among Swedish employees.", "authors": [{"family": "Blomqvist", "given": "Sandra", "initials": "S"}, {"family": "H\u00f6gn\u00e4s", "given": "Robin S", "initials": "RS"}, {"family": "Virtanen", "given": "Marianna", "initials": "M"}, {"family": "LaMontagne", "given": "Anthony D", "initials": "AD"}, {"family": "Magnusson Hanson", "given": "Linda L", "initials": "LL"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "SSM Popul Health", "issn": "2352-8273", "issn-l": null, "volume": "22", "issue": null, "pages": "101424"}, "abstract": "The COVID-19 pandemic led to permanent and temporary job losses but the mental health consequences of different types of employment transitions are not well-understood. In particular, knowledge is scarce concerning furloughs, which was a common job protection strategy in many high- and upper middle-income countries during this crisis. This study focuses on how different types of job instability and job loss during the pandemic influences depression and anxiety in the context of Sweden. A subset of participants from the Swedish Longitudinal Occupational Survey of Health were contacted in February 2021 and again in February 2022. A total of 1558 individuals participated in either or both waves and worked before the pandemic. We examined whether i) workplace downsizing, ii) furlough, or iii) unemployment/job loss were associated with depression and anxiety over this one-year period during the pandemic. Logistic regression models with cluster-robust standard errors were estimated, adjusting for sociodemographic factors and prior mental health problems. Effect modification by sex and prior mental health problems was also examined. In comparison to stable employment, being furloughed was unrelated to mental health, while experiencing workplace downsizing during the pandemic was associated with an increased risk of anxiety (adjusted Odds Ratio (OR) = 2.09, 95% Confidence interval (CI) = 1.08-4.05). Job loss/unemployment increased the risk of depression (OR = 1.91, 95% CI = 1.02-3.57) compared to being stably employed, but the risk estimate crossed unity when considering prior mental health status. No effect modification by sex or by prior mental health problems was found. This study found that while job loss and downsizing during the COVID-19 pandemic were associated with depression and anxiety, respectively, being furloughed was not. These findings thus suggest that job retention schemes in the form of short-time work allowances, as implemented in Sweden during the COVID-19 pandemic, may prevent mental health problems among employees during economic crises.", "doi": "10.1016/j.ssmph.2023.101424", "pmid": "37159634", "labels": {"Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10158169"}, {"db": "pii", "key": "S2352-8273(23)00089-7"}], "notes": [], "created": "2023-10-04T05:11:24.229Z", "modified": "2023-10-04T07:11:22.409Z"}, {"entity": "publication", "iuid": "4456be75b63f4527b96167b7ef4a4631", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4456be75b63f4527b96167b7ef4a4631.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4456be75b63f4527b96167b7ef4a4631"}}, "title": "In vitro high-content tissue models to address precision medicine challenges.", "authors": [{"family": "Afewerki", "given": "Samson", "initials": "S"}, {"family": "Stocco", "given": "Thiago Domingues", "initials": "TD"}, {"family": "Rosa da Silva", "given": "Andr\u00e9 Diniz", "initials": "AD"}, {"family": "Aguiar Furtado", "given": "Andr\u00e9 Sales", "initials": "AS"}, {"family": "Fernandes de Sousa", "given": "Gustavo", "initials": "G"}, {"family": "Ruiz-Esparza", "given": "Guillermo U", "initials": "GU"}, {"family": "Webster", "given": "Thomas J", "initials": "TJ"}, {"family": "Marciano", "given": "Fernanda R", "initials": "FR"}, {"family": "Str\u00f8mme", "given": "Maria", "initials": "M"}, {"family": "Zhang", "given": "Yu Shrike", "initials": "YS", "orcid": "0000-0002-0045-0808", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a7c59d189474a49a590ae7fcb4f294d.json"}}, {"family": "Lobo", "given": "Anderson Oliveira", "initials": "AO"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Mol Aspects Med", "issn": "1872-9452", "pages": "101108", "volume": "91", "issn-l": null}, "abstract": "The field of precision medicine allows for tailor-made treatments specific to a patient and thereby improve the efficiency and accuracy of disease prevention, diagnosis, and treatment and at the same time would reduce the cost, redundant treatment, and side effects of current treatments. Here, the combination of organ-on-a-chip and bioprinting into engineering high-content in vitro tissue models is envisioned to address some precision medicine challenges. This strategy could be employed to tackle the current coronavirus disease 2019 (COVID-19), which has made a significant impact and paradigm shift in our society. Nevertheless, despite that vaccines against COVID-19 have been successfully developed and vaccination programs are already being deployed worldwide, it will likely require some time before it is available to everyone. Furthermore, there are still some uncertainties and lack of a full understanding of the virus as demonstrated in the high number new mutations arising worldwide and reinfections of already vaccinated individuals. To this end, efficient diagnostic tools and treatments are still urgently needed. In this context, the convergence of bioprinting and organ-on-a-chip technologies, either used alone or in combination, could possibly function as a prominent tool in addressing the current pandemic. This could enable facile advances of important tools, diagnostics, and better physiologically representative in vitro models specific to individuals allowing for faster and more accurate screening of therapeutics evaluating their efficacy and toxicity. This review will cover such technological advances and highlight what is needed for the field to mature for tackling the various needs for current and future pandemics as well as their relevancy towards precision medicine.", "doi": "10.1016/j.mam.2022.101108", "pmid": "35987701", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9384546"}, {"db": "pii", "key": "S0098-2997(22)00053-X"}], "notes": [], "created": "2022-09-12T18:48:08.519Z", "modified": "2023-06-19T15:33:47.094Z"}, {"entity": "publication", "iuid": "7bcff8cad7644b8080abab3d4e51f599", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7bcff8cad7644b8080abab3d4e51f599.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7bcff8cad7644b8080abab3d4e51f599"}}, "title": "High Prevalence of SARS-CoV-2 Omicron Infection Despite High Seroprevalence, Sweden, 2022.", "authors": [{"family": "Groenheit", "given": "Ramona", "initials": "R"}, {"family": "Bacchus", "given": "Philip", "initials": "P"}, {"family": "Galanis", "given": "Ilias", "initials": "I"}, {"family": "Sond\u00e9n", "given": "Klara", "initials": "K"}, {"family": "Bujila", "given": "Ioana", "initials": "I"}, {"family": "Efimova", "given": "Tatiana", "initials": "T"}, {"family": "Garli", "given": "Fredrik", "initials": "F"}, {"family": "Lindsj\u00f6", "given": "Oskar Karlsson", "initials": "OK"}, {"family": "Mansj\u00f6", "given": "Mikael", "initials": "M"}, {"family": "Movert", "given": "Elin", "initials": "E"}, {"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Rapp", "given": "Marie", "initials": "M"}, {"family": "Sperk", "given": "Maike", "initials": "M"}, {"family": "S\u00f6derholm", "given": "Sandra", "initials": "S"}, {"family": "Asin", "given": "Karin Valentin", "initials": "KV"}, {"family": "Zanetti", "given": "Sarah", "initials": "S"}, {"family": "Karlberg", "given": "Maria Lind", "initials": "ML"}, {"family": "Br\u00e5ve", "given": "Andreas", "initials": "A"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Emerg Infect Dis", "issn": "1080-6059", "volume": "29", "issue": "6", "pages": "1240-1243", "issn-l": null}, "abstract": "We performed 2 surveys during 2022 to estimate point prevalences of SARS-CoV-2 infection compared with overall seroprevalence in Sweden. Point prevalence was 1.4% in March and 1.5% in September. Estimated seroprevalence was >80%, including among unvaccinated children. Continued SARS-CoV-2 surveillance is necessary for detecting emerging, possibly more pathogenic variants.", "doi": "10.3201/eid2906.221862", "pmid": "37141616", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10202879"}], "notes": [], "created": "2023-07-13T11:37:13.361Z", "modified": "2023-07-13T11:37:13.365Z"}, {"entity": "publication", "iuid": "6336bc6ca2c14794b41168651fdfdaf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6336bc6ca2c14794b41168651fdfdaf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6336bc6ca2c14794b41168651fdfdaf3"}}, "title": "Establishing severe acute respiratory infection (SARI) surveillance in a sentinel hospital, Ireland, 2021 to 2022.", "authors": [{"family": "Brady", "given": "Melissa", "initials": "M"}, {"family": "Duffy", "given": "Roisin", "initials": "R"}, {"family": "Domegan", "given": "Lisa", "initials": "L"}, {"family": "Salmon", "given": "Abigail", "initials": "A"}, {"family": "Maharjan", "given": "Binita", "initials": "B"}, {"family": "O'Broin", "given": "Cathal", "initials": "C"}, {"family": "Bennett", "given": "Charlene", "initials": "C"}, {"family": "Christle", "given": "James", "initials": "J"}, {"family": "Connell", "given": "Jeff", "initials": "J"}, {"family": "Feeney", "given": "Laura", "initials": "L"}, {"family": "Nurdin", "given": "Nadra", "initials": "N"}, {"family": "Mallon", "given": "Patrick", "initials": "P"}, {"family": "Doran", "given": "Peter", "initials": "P"}, {"family": "McNamara", "given": "Rosa", "initials": "R"}, {"family": "O'Grady", "given": "Sarah", "initials": "S"}, {"family": "McDermott", "given": "Sinead", "initials": "S"}, {"family": "Petty-Saphon", "given": "Naomi", "initials": "N"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "23", "pages": null}, "abstract": "BackgroundIn 2020, due to the COVID-19 pandemic, the European Centre for Disease Prevention and Control (ECDC) accelerated development of European-level severe acute respiratory infection (SARI) surveillance.AimWe aimed to establish SARI surveillance in one Irish hospital as part of a European network E-SARI-NET.MethodsWe used routine emergency department records to identify cases in one adult acute hospital. The SARI case definition was adapted from the ECDC clinical criteria for a possible COVID-19 case. Clinical data were collected using an online questionnaire. Cases were tested for SARS-CoV-2, influenza and respiratory syncytial virus (RSV), including whole genome sequencing (WGS) on SARS-CoV-2 RNA-positive samples and viral characterisation/sequencing on influenza RNA-positive samples. Descriptive analysis was conducted for SARI cases hospitalised between July 2021 and April 2022.ResultsOverall, we identified 437 SARI cases, the incidence ranged from two to 28 cases per week (0.7-9.2/100,000 hospital catchment population). Of 431 cases tested for SARS-CoV-2 RNA, 226 (52%) were positive. Of 349 (80%) cases tested for influenza and RSV RNA, 15 (4.3%) were positive for influenza and eight (2.3%) for RSV. Using WGS, we identified Delta- and Omicron-dominant periods. The resource-intensive nature of manual clinical data collection, specimen management and laboratory supply shortages for influenza and RSV testing were challenging.ConclusionWe successfully established SARI surveillance as part of E-SARI-NET. Expansion to additional sentinel sites is planned following formal evaluation of the existing system. SARI surveillance requires multidisciplinary collaboration, automated data collection where possible, and dedicated personnel resources, including for specimen management.", "doi": "10.2807/1560-7917.ES.2023.28.23.2200740", "pmid": "37289427", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10318943"}], "notes": [], "created": "2023-10-04T09:30:04.862Z", "modified": "2023-10-04T09:47:34.315Z"}, {"entity": "publication", "iuid": "99d71e90a9a64e30a3fdf43372df352c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/99d71e90a9a64e30a3fdf43372df352c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/99d71e90a9a64e30a3fdf43372df352c"}}, "title": "Differences in incidence, nature of symptoms, and duration of long COVID among hospitalised migrant and non-migrant patients in the Netherlands: a retrospective cohort study.", "authors": [{"family": "Chilunga", "given": "Felix Patience", "initials": "FP"}, {"family": "Appelman", "given": "Brent", "initials": "B"}, {"family": "van Vugt", "given": "Michele", "initials": "M"}, {"family": "Kalverda", "given": "Kirsten", "initials": "K"}, {"family": "Smeele", "given": "Patrick", "initials": "P"}, {"family": "van Es", "given": "Josien", "initials": "J"}, {"family": "Wiersinga", "given": "Willem Joost", "initials": "WJ"}, {"family": "Rostila", "given": "Mikael", "initials": "M"}, {"family": "Prins", "given": "Maria", "initials": "M"}, {"family": "Stronks", "given": "Karien", "initials": "K"}, {"family": "Norredam", "given": "Marie", "initials": "M"}, {"family": "Agyemang", "given": "Charles", "initials": "C"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "issn-l": null, "volume": "29", "issue": null, "pages": "100630"}, "abstract": "Comprehensive data on long COVID across ethnic and migrant groups are lacking. We investigated incidence, nature of symptoms, clinical predictors, and duration of long COVID among COVID-19 hospitalised patients in the Netherlands by migration background (Dutch, Turkish, Moroccan, and Surinamese origin, Others).\r\n\r\nWe used COVID-19 admissions and follow up data (January 2021-July 2022) from Amsterdam University Medical Centers. We calculated long COVID incidence proportions per NICE guidelines by migration background and assessed for clinical predictors via robust Poisson regressions. We then examined associations between migration background and long COVID using robust Poisson regressions and adjusted for derived clinical predictors, and other biologically relevant factors. We also assessed long COVID symptom persistence at one-year post-discharge.\r\n\r\n1886 patients were included. 483 patients had long COVID (26%, 95% CI 24-28%) at 12 weeks post-discharge. Symptoms like dizziness, joint pain, insomnia, and headache varied by migration background. Clinical predictors of long COVID were female sex, hospital admission duration, intensive care unit admission, and receiving oxygen, or corticosteroid therapy. Long COVID risk was higher among patients with migration background than Dutch origin patients after adjustments for derived clinical predictors, age, smoking, vaccination status, comorbidities and remdesivir treatment. Only 14% of long COVID symptoms persisted at one-year post-discharge.\r\n\r\nThere are significant differences in occurrence, nature of symptoms, and duration of long COVID by migration background. Studies assessing the spectrum of functional limitation and access to post-COVID healthcare are needed to help plan for appropriate and accessible healthcare interventions.\r\n\r\nThe Amsterdam UMC COVID-19 biobank is supported by the Amsterdam UMC Corona Research Fund and the Talud Foundation (Stichting Talud). The current analyses were supported by the Novo Nordisk Foundation [NNF21OC0067528].", "doi": "10.1016/j.lanepe.2023.100630", "pmid": "37261215", "labels": {"Category: Post-COVID": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10079482"}, {"db": "pii", "key": "S2666-7762(23)00049-2"}], "notes": [], "created": "2023-10-04T09:32:34.156Z", "modified": "2023-10-04T11:11:02.084Z"}, {"entity": "publication", "iuid": "611d3dec80a4496989e28b0aad6ac03d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/611d3dec80a4496989e28b0aad6ac03d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/611d3dec80a4496989e28b0aad6ac03d"}}, "title": "COVID-19 infection in patients on long-term home parenteral nutrition for chronic intestinal failure.", "authors": [{"family": "Pironi", "given": "Loris", "initials": "L"}, {"family": "Jezerski", "given": "Denise", "initials": "D"}, {"family": "Sobocki", "given": "Jacek", "initials": "J"}, {"family": "Lal", "given": "Simon", "initials": "S"}, {"family": "Vanuytsel", "given": "Tim", "initials": "T"}, {"family": "Theilla", "given": "Miriam", "initials": "M"}, {"family": "Sasdelli", "given": "Anna S", "initials": "AS"}, {"family": "Chambrier", "given": "Cecile", "initials": "C"}, {"family": "Matysiak", "given": "Konrad", "initials": "K"}, {"family": "Aimasso", "given": "Umberto", "initials": "U"}, {"family": "Rasmussen", "given": "Henrik H", "initials": "HH"}, {"family": "Jukes", "given": "Amelia", "initials": "A"}, {"family": "Kunecki", "given": "Marek", "initials": "M"}, {"family": "Seguy", "given": "David", "initials": "D"}, {"family": "Schneider", "given": "St\u00e9phane M", "initials": "SM"}, {"family": "Daniels", "given": "Joanne", "initials": "J"}, {"family": "Poullenot", "given": "Florian", "initials": "F"}, {"family": "Mundi", "given": "Manpreet S", "initials": "MS"}, {"family": "Matras", "given": "Przemys\u0142aw", "initials": "P"}, {"family": "Folwarski", "given": "Marcin", "initials": "M"}, {"family": "Crivelli", "given": "Adriana", "initials": "A"}, {"family": "Wyer", "given": "Nicola", "initials": "N"}, {"family": "Ellegard", "given": "Lars", "initials": "L"}, {"family": "Santarpia", "given": "Lidia", "initials": "L"}, {"family": "Arvanitakis", "given": "Marianna", "initials": "M"}, {"family": "Spaggiari", "given": "Corrado", "initials": "C"}, {"family": "Lamprecht", "given": "Georg", "initials": "G"}, {"family": "Guglielmi", "given": "Francesco W", "initials": "FW"}, {"family": "Lezo", "given": "Antonella", "initials": "A"}, {"family": "Layec", "given": "Sabrina", "initials": "S"}, {"family": "Boluda", "given": "Esther Ramos", "initials": "ER"}, {"family": "Guz-Mark", "given": "Anat", "initials": "A"}, {"family": "Gandullia", "given": "Paolo", "initials": "P"}, {"family": "Cuerda", "given": "Cristina", "initials": "C"}, {"family": "Osland", "given": "Emma", "initials": "E"}, {"family": "Spagnuolo", "given": "Maria I", "initials": "MI"}, {"family": "Krznaric", "given": "Zeljko", "initials": "Z"}, {"family": "Masconale", "given": "Luisa", "initials": "L"}, {"family": "Chapman", "given": "Brooke", "initials": "B"}, {"family": "Ma\u00edz-Jim\u00e9nez", "given": "Mar\u00eda", "initials": "M"}, {"family": "Orlandoni", "given": "Paolo", "initials": "P"}, {"family": "Martins da Rocha", "given": "Mariana Hollanda", "initials": "MH"}, {"family": "Virgili-Casas", "given": "M Nuria", "initials": "MN"}, {"family": "Doitchinova-Simeonova", "given": "Maryana", "initials": "M"}, {"family": "Czako", "given": "Laszlo", "initials": "L"}, {"family": "Van Gossum", "given": "Andr\u00e8", "initials": "A"}, {"family": "D'Antiga", "given": "Lorenzo", "initials": "L"}, {"family": "Ee", "given": "Looi C", "initials": "LC"}, {"family": "Warodomwichit", "given": "Daruneewan", "initials": "D"}, {"family": "Taus", "given": "Marina", "initials": "M"}, {"family": "Kola\u010dek", "given": "Sanja", "initials": "S"}, {"family": "Thibault", "given": "Ronan", "initials": "R"}, {"family": "Verlato", "given": "Giovanna", "initials": "G"}, {"family": "Serralde-Z\u00fa\u00f1iga", "given": "Aurora E", "initials": "AE"}, {"family": "Botella-Carretero", "given": "Jos\u00e9 I", "initials": "JI"}, {"family": "Aguayo", "given": "Pilar Serrano", "initials": "PS"}, {"family": "Olveira", "given": "Gabriel", "initials": "G"}, {"family": "Chomtho", "given": "Sirinuch", "initials": "S"}, {"family": "Pisprasert", "given": "Veeradej", "initials": "V"}, {"family": "Moisejevs", "given": "Georgijs", "initials": "G"}, {"family": "Murillo", "given": "Ana Zugasti", "initials": "AZ"}, {"family": "J\u00e1uregui", "given": "Ma Estrella Petrina", "initials": "MEP"}, {"family": "D\u00edez", "given": "Marta Bueno", "initials": "MB"}, {"family": "Jahit", "given": "Mohammad Shukri", "initials": "MS"}, {"family": "Densupsoontorn", "given": "Narumon", "initials": "N"}, {"family": "Tamer", "given": "Ali", "initials": "A"}, {"family": "Brillanti", "given": "Giorgia", "initials": "G"}, {"family": "Joly", "given": "Francisca", "initials": "F"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Clin Nutr ESPEN", "issn": "2405-4577", "issn-l": null, "volume": "55", "issue": null, "pages": "212-220"}, "abstract": "To investigate the incidence and the severity of COVID-19 infection in patients enrolled in the database for home parenteral nutrition (HPN) for chronic intestinal failure (CIF) of the European Society for Clinical Nutrition and Metabolism (ESPEN).\r\n\r\nPeriod of observation: March 1st, 2020 March 1st, 2021.\r\n\r\npatients included in the database since 2015 and still receiving HPN on March 1st, 2020 as well as new patients included in the database during the period of observation. Data related to the previous 12 months and recorded on March 1st 2021: 1) occurrence of COVID-19 infection since the beginning of the pandemic (yes, no, unknown); 2) infection severity (asymptomatic; mild, no-hospitalization; moderate, hospitalization no-ICU; severe, hospitalization in ICU); 3) vaccinated against COVID-19 (yes, no, unknown); 4) patient outcome on March 1st 2021: still on HPN, weaned off HPN, deceased, lost to follow up.\r\n\r\nSixty-eight centres from 23 countries included 4680 patients. Data on COVID-19 were available for 55.1% of patients. The cumulative incidence of infection was 9.6% in the total group and ranged from 0% to 21.9% in the cohorts of individual countries. Infection severity was reported as: asymptomatic 26.7%, mild 32.0%, moderate 36.0%, severe 5.3%. Vaccination status was unknown in 62.0% of patients, non-vaccinated 25.2%, vaccinated 12.8%. Patient outcome was reported as: still on HPN 78.6%, weaned off HPN 10.6%, deceased 9.7%, lost to follow up 1.1%. A higher incidence of infection (p = 0.04), greater severity of infection (p < 0.001) and a lower vaccination percentage (p = 0.01) were observed in deceased patients. In COVID-19 infected patients, deaths due to infection accounted for 42.8% of total deaths.\r\n\r\nIn patients on HPN for CIF, the incidence of COVID-19 infection differed greatly among countries. Although the majority of cases were reported to be asymptomatic or have mild symptoms only, COVID-19 was reported to be fatal in a significant proportion of infected patients. Lack of vaccination was associated with a higher risk of death.", "doi": "10.1016/j.clnesp.2023.03.008", "pmid": "37202049", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10060187"}, {"db": "pii", "key": "S2405-4577(23)00075-X"}], "notes": [], "created": "2023-10-04T05:11:29.125Z", "modified": "2023-10-04T07:13:30.687Z"}, {"entity": "publication", "iuid": "19c8f56c67384179ae91bca3ce302683", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19c8f56c67384179ae91bca3ce302683.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19c8f56c67384179ae91bca3ce302683"}}, "title": "COVID-19 and unintended steps towards further equity in global health research.", "authors": [{"family": "Willows", "given": "Tamara Mulenga", "initials": "TM", "orcid": "0000-0003-0760-5574", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a81a219f7e1647789a38f3bdfd754b16.json"}}, {"family": "Oliwa", "given": "Jacquie", "initials": "J"}, {"family": "Onyango", "given": "Onesmus", "initials": "O"}, {"family": "Mkumbo", "given": "Elibariki", "initials": "E"}, {"family": "Maiba", "given": "John", "initials": "J"}, {"family": "Schell", "given": "Carl Otto", "initials": "CO", "orcid": "0000-0002-7904-1336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a40b337b45b471d97a102c355c9d874.json"}}, {"family": "Baker", "given": "Tim", "initials": "T", "orcid": "0000-0001-8727-7018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1454fc20049b4d47865268adf16d104a.json"}}, {"family": "McKnight", "given": "Jacob", "initials": "J", "orcid": "0000-0003-1340-2618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ab57e6a797048338416851ae43170a9.json"}}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "issn-l": "2059-7908", "volume": "8", "issue": "6", "pages": null}, "abstract": "There was, and possibly still is, potential for COVID-19 to disrupt power inequities and contribute to positive transformation in global health research that increases equity. While there is consensus about the need to decolonise by transforming global health, and a roadmap outlining how we could approach it, there are few examples of steps that could be taken to transform the mechanics of global health research. This paper contributes lessons learnt from experiences and reflections of our diverse multinational team of researchers involved in a multicountry research project. We demonstrate the positive impact on our research project of making further steps towards improving equity within our research practices. Some of the approaches adopted include redistributing power to researchers from the countries of interest at various stages in their career, by involving the whole team in decisions about the research; meaningfully involving the whole team in research data analysis; and providing opportunities for all researchers from the countries of interest to voice their perspectives as first authors in publications. Although this approach is consistent with how research guidance suggests research should be run, in reality it does not often happen in this way. The authors of this paper hope that by sharing our experience, we can contribute towards discussions about the processes required to continue developing a global health sector that is equitable and inclusive.", "doi": "10.1136/bmjgh-2023-011888", "pmid": "37328283", "labels": {"Type: Other": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10276961"}, {"db": "pii", "key": "bmjgh-2023-011888"}], "notes": [], "created": "2023-10-04T09:33:08.709Z", "modified": "2023-10-04T11:17:35.824Z"}, {"entity": "publication", "iuid": "3dafb03d45fe4acdb6cd32d1298d72af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3dafb03d45fe4acdb6cd32d1298d72af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3dafb03d45fe4acdb6cd32d1298d72af"}}, "title": "A comprehensive health effects assessment of the use of sanitizers and disinfectants during COVID-19 pandemic: a global survey.", "authors": [{"family": "Hashemi", "given": "Fallah", "initials": "F"}, {"family": "Hoepner", "given": "Lori", "initials": "L"}, {"family": "Hamidinejad", "given": "Farahnaz Soleimani", "initials": "FS"}, {"family": "Haluza", "given": "Daniela", "initials": "D"}, {"family": "Afrashteh", "given": "Sima", "initials": "S"}, {"family": "Abbasi", "given": "Alireza", "initials": "A"}, {"family": "Omeragi\u0107", "given": "Elma", "initials": "E"}, {"family": "Imamovi\u0107", "given": "Belma", "initials": "B"}, {"family": "Rasheed", "given": "Narin A", "initials": "NA"}, {"family": "Taher", "given": "Taqi M J", "initials": "TMJ"}, {"family": "Kurniasari", "given": "Fitri", "initials": "F"}, {"family": "Wazqar", "given": "Dhuha Youssef", "initials": "DY"}, {"family": "Apal\u0131", "given": "\u00d6zge Ceren", "initials": "\u00d6C"}, {"family": "Yildirim", "given": "Ayca Demir", "initials": "AD"}, {"family": "Zhao", "given": "Bo", "initials": "B"}, {"family": "Kalikyan", "given": "Zaruhi", "initials": "Z"}, {"family": "Guo", "given": "Cui", "initials": "C"}, {"family": "Valbuena", "given": "Andrea Chong", "initials": "AC"}, {"family": "Mititelu", "given": "Magdalena", "initials": "M"}, {"family": "Pando", "given": "Carolina Mart\u00ednez", "initials": "CM"}, {"family": "Saridi", "given": "Maria", "initials": "M"}, {"family": "Toska", "given": "Aikaterini", "initials": "A"}, {"family": "Cuba", "given": "Magalys Lopez", "initials": "ML"}, {"family": "Kwadzokpui", "given": "Precious Kwablah", "initials": "PK"}, {"family": "Tadele", "given": "Niguse", "initials": "N"}, {"family": "Nasibova", "given": "Tohfa", "initials": "T"}, {"family": "Harsch", "given": "Stefanie", "initials": "S"}, {"family": "Munkh-Erdene", "given": "Luvsan", "initials": "L"}, {"family": "Menawi", "given": "Wafaa", "initials": "W"}, {"family": "Evangelou", "given": "Efi", "initials": "E"}, {"family": "Dimova", "given": "Antoniya", "initials": "A"}, {"family": "Marinov", "given": "Dimitar", "initials": "D"}, {"family": "Dimitrova", "given": "Teodora", "initials": "T"}, {"family": "Shalimova", "given": "Anna", "initials": "A"}, {"family": "Fouly", "given": "Howieda", "initials": "H"}, {"family": "Suraya", "given": "Anna", "initials": "A"}, {"family": "da Silva Faquim", "given": "Juliana Pereira", "initials": "JP"}, {"family": "Oumayma", "given": "Bouadil", "initials": "B"}, {"family": "Annunziato", "given": "Maria Antonieta", "initials": "MA"}, {"family": "Lalo", "given": "Rezarta", "initials": "R"}, {"family": "Papastavrou", "given": "Evridiki", "initials": "E"}, {"family": "Ade", "given": "Anju D", "initials": "AD"}, {"family": "Caminada", "given": "Susanna", "initials": "S"}, {"family": "Stojkov", "given": "Svetlana", "initials": "S"}, {"family": "Narvaez", "given": "Carmen Gloria", "initials": "CG"}, {"family": "Mudau", "given": "Lutendo Sylvia", "initials": "LS"}, {"family": "Rassas", "given": "Ines", "initials": "I"}, {"family": "Michel", "given": "Daphnee", "initials": "D"}, {"family": "Kaynar", "given": "Nur Sema", "initials": "NS"}, {"family": "Iqbal", "given": "Sehar", "initials": "S"}, {"family": "Elshwekh", "given": "Halla", "initials": "H"}, {"family": "Hossain", "given": "Irin", "initials": "I"}, {"family": "Al-Fayyadh", "given": "Sadeq", "initials": "S"}, {"family": "Sydorchuk", "given": "Aniuta", "initials": "A"}, {"family": "Alnusairat", "given": "Dua'a M H", "initials": "DMH"}, {"family": "Abdullahi", "given": "Asli Mohamed", "initials": "AM"}, {"family": "Iqbal", "given": "Neelam", "initials": "N"}, {"family": "Pandey", "given": "Apsara", "initials": "A"}, {"family": "G\u00f3mez-G\u00f3mez", "given": "Brenda", "initials": "B"}, {"family": "Akyildiz", "given": "Aysenur Gunaydin", "initials": "AG"}, {"family": "Morosan", "given": "Elena", "initials": "E"}, {"family": "Dwarica", "given": "Daniella", "initials": "D"}, {"family": "Dorj", "given": "Gantuya", "initials": "G"}, {"family": "Hasan", "given": "Sumaya Yusuf", "initials": "SY"}, {"family": "Al-Shdayfat", "given": "Noha M", "initials": "NM"}, {"family": "Knezevic", "given": "Bojana", "initials": "B"}, {"family": "Valladares", "given": "Wendy", "initials": "W"}, {"family": "Severi", "given": "Cecilia", "initials": "C"}, {"family": "Fuentes", "given": "Sofia Cuba", "initials": "SC"}, {"family": "Augusto", "given": "Sofia", "initials": "S"}, {"family": "Sidorova", "given": "Elizaveta", "initials": "E"}, {"family": "Moelyaningrum", "given": "Anita Dewi", "initials": "AD"}, {"family": "Alawad", "given": "Tafaul", "initials": "T"}, {"family": "Khalid", "given": "Atiqa", "initials": "A"}, {"family": "Elehamer", "given": "Nafisa M K", "initials": "NMK"}, {"family": "Mihaylova", "given": "Anna", "initials": "A"}, {"family": "Tsigengagel", "given": "Oxana", "initials": "O"}, {"family": "Menouni", "given": "Aziza", "initials": "A"}, {"family": "Wojtecka", "given": "Agnieszka", "initials": "A"}, {"family": "Hod", "given": "Rozita", "initials": "R"}, {"family": "Idayat", "given": "Yusuf Banke", "initials": "YB"}, {"family": "Othman", "given": "Khadija", "initials": "K"}, {"family": "Harfouch", "given": "Rim M", "initials": "RM"}, {"family": "Paunov", "given": "Tsonco", "initials": "T"}, {"family": "Omar", "given": "Meruyert", "initials": "M"}, {"family": "Benderli", "given": "Nana Christine", "initials": "NC"}, {"family": "Nurika", "given": "Globila", "initials": "G"}, {"family": "Amjad", "given": "Sana", "initials": "S"}, {"family": "Elnoamany", "given": "Salma", "initials": "S"}, {"family": "Elesrigy", "given": "Fatma", "initials": "F"}, {"family": "Shaban", "given": "Marwa Mamdouh", "initials": "MM"}, {"family": "Acevedo-L\u00f3pez", "given": "Dom\u00e9nica", "initials": "D"}, {"family": "Kartashova", "given": "Maria", "initials": "M"}, {"family": "Khalaf", "given": "Atika", "initials": "A"}, {"family": "Jaafar", "given": "Sabah Abdullah", "initials": "SA"}, {"family": "Kadhim", "given": "Taisir A", "initials": "TA"}, {"family": "Hweissa", "given": "Nada Ab", "initials": "NA"}, {"family": "Teng", "given": "Yulong", "initials": "Y"}, {"family": "Mohammed", "given": "Fatima E", "initials": "FE"}, {"family": "Sasikumar", "given": "Thayahlini", "initials": "T"}, {"family": "Hikaambo", "given": "Christabel Nangandu", "initials": "CN"}, {"family": "Kharat", "given": "Aditi", "initials": "A"}, {"family": "Lyamtseva", "given": "Ulyana", "initials": "U"}, {"family": "Aldeeb", "given": "Maya Arfan", "initials": "MA"}, {"family": "Pawlas", "given": "Natalia", "initials": "N"}, {"family": "Khorolsuren", "given": "Lkhagvasuren", "initials": "L"}, {"family": "Koonjul", "given": "Roopeshwaree Pallavi", "initials": "RP"}, {"family": "Ma\u00efnassara", "given": "Halima Boubacar", "initials": "HB"}, {"family": "Chahal", "given": "Priyanka", "initials": "P"}, {"family": "Wangeci", "given": "Rose W", "initials": "RW"}, {"family": "Kumar", "given": "Ainur B", "initials": "AB"}, {"family": "Zamora-Corrales", "given": "Irina", "initials": "I"}, {"family": "Gracy", "given": "Stella", "initials": "S"}, {"family": "Mahamat", "given": "Maimouna", "initials": "M"}, {"family": "Adamczyk", "given": "Jakub", "initials": "J"}, {"family": "Rahman", "given": "Haliza Abdul", "initials": "HA"}, {"family": "Matiashova", "given": "Lolita", "initials": "L"}, {"family": "Elsherif", "given": "Omneya Ezzat", "initials": "OE"}, {"family": "Alkhateeb", "given": "Nazdar E", "initials": "NE"}, {"family": "Aleaga", "given": "Yamil\u00e9", "initials": "Y"}, {"family": "Bahrami", "given": "Shima", "initials": "S"}, {"family": "Al-Salihy", "given": "Shaimaa Rahem", "initials": "SR"}, {"family": "Cabrera-Galeana", "given": "Paula", "initials": "P"}, {"family": "Lalic-Popovic", "given": "Mladena", "initials": "M"}, {"family": "Brown-Myrie", "given": "Eugenie", "initials": "E"}, {"family": "Bhandari", "given": "Divya", "initials": "D"}, {"family": "Mayaboti", "given": "Cinderella Akbar", "initials": "CA"}, {"family": "Stani\u0161i\u0107", "given": "Svetlana", "initials": "S"}, {"family": "Pestic", "given": "Sanda Kreitmayer", "initials": "SK"}, {"family": "Bektay", "given": "Muhammed Yunus", "initials": "MY"}, {"family": "Al Sabbah", "given": "Haleama", "initials": "H"}, {"family": "Hashemi", "given": "Saber", "initials": "S"}, {"family": "Assia", "given": "Bouchetara", "initials": "B"}, {"family": "Merritt", "given": "Anne-Sophie", "initials": "A"}, {"family": "Ramzi", "given": "Zhian", "initials": "Z"}, {"family": "Baboolal", "given": "Himawatee", "initials": "H"}, {"family": "Isstaif", "given": "Juman", "initials": "J"}, {"family": "Shami", "given": "Rula", "initials": "R"}, {"family": "Saad", "given": "Rahma", "initials": "R"}, {"family": "Nyirongo", "given": "Temwanani", "initials": "T"}, {"family": "Hoseini", "given": "Mohammad", "initials": "M", "orcid": "0000-0001-5180-3047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88d9726fdadb43758c8e8e5d941b1267.json"}}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Environ Sci Pollut Res Int", "issn": "1614-7499", "issn-l": null, "volume": "30", "issue": "28", "pages": "72368-72388"}, "abstract": "COVID-19 has affected all aspects of human life so far. From the outset of the pandemic, preventing the spread of COVID-19 through the observance of health protocols, especially the use of sanitizers and disinfectants was given more attention. Despite the effectiveness of disinfection chemicals in controlling and preventing COVID-19, there are critical concerns about their adverse effects on human health. This study aims to assess the health effects of sanitizers and disinfectants on a global scale. A total of 91,056 participants from 154 countries participated in this cross-sectional study. Information on the use of sanitizers and disinfectants and health was collected using an electronic questionnaire, which was translated into 26 languages via web-based platforms. The findings of this study suggest that detergents, alcohol-based substances, and chlorinated compounds emerged as the most prevalent chemical agents compared to other sanitizers and disinfectants examined. Most frequently reported health issues include skin effects and respiratory effects. The Chi-square test showed a significant association between chlorinated compounds (sodium hypochlorite and per-chlorine) with all possible health effects under investigation (p-value <0.001). Examination of risk factors based on multivariate logistic regression analysis showed that alcohols and alcohols-based materials were associated with skin effects (OR, 1.98; 95%CI, 1.87-2.09), per-chlorine was associated with eye effects (OR, 1.83; 95%CI, 1.74-1.93), and highly likely with itching and throat irritation (OR, 2.00; 95%CI, 1.90-2.11). Furthermore, formaldehyde was associated with a higher prevalence of neurological effects (OR, 2.17; 95%CI, 1.92-2.44). Furthermore, formaldehyde was associated with a higher prevalence of neurological effects (OR, 2.17; 95%CI, 1.92-2.44). The use of sodium hypochlorite and per-chlorine also had a high chance of having respiratory effects. The findings of the current study suggest that health authorities need to implement more awareness programs about the side effects of using sanitizers and disinfectants during viral epidemics especially when they are used or overused.", "doi": "10.1007/s11356-023-27197-6", "pmid": "37166731", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10173232"}, {"db": "pii", "key": "10.1007/s11356-023-27197-6"}], "notes": [], "created": "2023-10-04T05:12:04.405Z", "modified": "2023-10-04T07:27:53.594Z"}, {"entity": "publication", "iuid": "8d005afcbfa84b5d896a0c02be7a01e0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d005afcbfa84b5d896a0c02be7a01e0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d005afcbfa84b5d896a0c02be7a01e0"}}, "title": "Changes in lifestyle, adiposity, and cardiometabolic markers among young adults in Sweden during the COVID-19 pandemic.", "authors": [{"family": "Ekstr\u00f6m", "given": "Sandra", "initials": "S"}, {"family": "Andersson", "given": "Niklas", "initials": "N"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "Georgelis", "given": "Antonios", "initials": "A"}, {"family": "Ljungman", "given": "Petter L S", "initials": "PLS"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Bergstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2023-05-31", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "23", "issue": "1", "pages": "1026"}, "abstract": "The COVID-19 pandemic has impacted on public health in several ways. The aim of the study was to investigate changes in lifestyle, adiposity, and cardiometabolic markers among young adults in Sweden during the COVID-19 pandemic and their determinants.\r\n\r\nThe study included 1 004 participants from the population-based birth cohort BAMSE. Anthropometrics, body composition (bioelectric impedance analyses), pulse, and blood pressure were measured before (December 2016-May 2019; mean age 22.6 years) and during (October 2020-June 2021; mean age 25.7 years) the COVID-19 pandemic. Lifestyle changes during the pandemic were assessed through a questionnaire.\r\n\r\nAll measures of adiposity (weight, BMI, body fat percentage, trunk fat percentage) and cardiometabolic markers (blood pressure, pulse) increased during the study period (e.g., body fat percentage by a median of + 0.8% in females, p < 0.001, and + 1.5% in males, p < 0.001). Male sex, non-Scandinavian ethnicity, BMI status (underweight and obesity), and changes in lifestyle factors, e.g., decreased physical activity during the pandemic, were associated with higher increase in BMI and/or adiposity.\r\n\r\nLifestyle factors, adiposity and cardiometabolic markers may have been adversely affected among young adults in Sweden during the COVID-19 pandemic compared with the preceding years. Targeted public health measures to reduce obesity and improve healthy lifestyle are important to prevent future non-communicable diseases.", "doi": "10.1186/s12889-023-15998-w", "pmid": "37259040", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Funder: VR": null, "Funder: Forte": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10230124"}, {"db": "pii", "key": "10.1186/s12889-023-15998-w"}], "notes": [], "created": "2023-10-04T09:30:58.793Z", "modified": "2023-10-04T10:39:32.251Z"}, {"entity": "publication", "iuid": "d68c8a168fc6476b970f546ee7eed474", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d68c8a168fc6476b970f546ee7eed474.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d68c8a168fc6476b970f546ee7eed474"}}, "title": "Reduced Binding between Omicron B.1.1.529 and the Human ACE2 Receptor in a Surrogate Virus Neutralization Test for SARS-CoV-2.", "authors": [{"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Kolstad", "given": "Linda", "initials": "L"}, {"family": "Akaberi", "given": "Dario", "initials": "D"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD", "orcid": "0000-0002-7075-1059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4c50079915c44d39c996741c6156bfa.json"}}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B", "orcid": "0000-0003-0229-093X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ffe383004ef44bc6b7639ce49e8f4295.json"}}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5", "orcid": "0000-0001-8608-6551", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d8e20ea891e4e038dddde238aa79627.json"}}], "type": "journal article", "published": "2023-05-30", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "15", "issue": "6", "pages": null}, "abstract": "The current gold standard assay for detecting neutralizing antibodies (NAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the conventional virus neutralization test (cVNT), which requires infectious virus and a biosafety level 3 laboratory. Here, we report the development of a SARS-CoV-2 surrogate virus neutralization test (sVNT) that, with Luminex technology, detects NAbs. The assay was designed to mimic the virus-host interaction and is based on antibody blockage between the human angiotensin-converting enzyme 2 (hACE2) receptor and the spike (S) protein of the Wuhan, Delta, and Omicron (B.1.1.529) variants of SARS-CoV-2. The sVNT proved to have a 100% correlation with a SARS-CoV-2 cVNT regarding qualitative results. Binding between the hACE2 receptor and the S1 domain of the B.1.1.529 lineage of the Omicron variant was not observed in the assay but between the receptor and an S1 + S2 trimer and the receptor binding domain (RBD) in a reduced manner, suggesting less efficient receptor binding for the B.1.1.529 Omicron variant. The results indicate that the SARS-CoV-2 sVNT is a suitable tool for both the research community and the public health service, as it may serve as an efficient diagnostic alternative to the cVNT.", "doi": "10.3390/v15061280", "pmid": "37376580", "labels": {"Category: Proteins": null, "Funder: VR": null, "Category: Serology": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC10301322"}, {"db": "pii", "key": "v15061280"}], "notes": [], "created": "2023-10-04T09:31:46.194Z", "modified": "2023-10-04T10:54:03.277Z"}, {"entity": "publication", "iuid": "de3655e5b5104cc0a72eb07b0ea09364", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/de3655e5b5104cc0a72eb07b0ea09364.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/de3655e5b5104cc0a72eb07b0ea09364"}}, "title": "Intensive care nurses' experiences of caring for patients during the COVID-19 pandemic based on an analysis of blog posts.", "authors": [{"family": "Skoglund", "given": "Karin", "initials": "K", "orcid": "0000-0001-8008-8169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e6fc2925ce9443e865e3dc39411af54.json"}}, {"family": "\u00c5hlman", "given": "Ebba", "initials": "E"}, {"family": "Mallin", "given": "Sofia", "initials": "S"}, {"family": "Holmgren", "given": "Jessica", "initials": "J", "orcid": "0000-0002-8551-3264", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a97a6a6656dc41f8ac7aad2547261322.json"}}], "type": "journal article", "published": "2023-05-30", "journal": {"title": "Nurs Crit Care", "issn": "1478-5153", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "In 2019, coronavirus disease 2019 (COVID-19) broke out worldwide, leading to a pandemic. Studies have shown that COVID-19 patients in intensive care units (ICUs) require more nursing care than other patients. ICU nurses who care for patients with COVID-19 have shown signs of psychological and physical strain.\r\n\r\nThe aim of this study was to illuminate ICU nurses' experiences of caring for patients with COVID-19 in ICUs during the first wave of the pandemic.\r\n\r\nA qualitative, descriptive and inductive approach was used.\r\n\r\nA total of 70 blog posts from 13 bloggers in the United States, Great Britain, Finland and Sweden were analysed using qualitative inductive manifest content analysis.\r\n\r\nThe results reveal an overall theme: 'An overturned existence under extreme conditions'. Furthermore, three categories-'the virus caused changes in work and private lives', 'unreasonable demands', and to hold on to caring ideals thanks to the support of others'-and seven subcategories were identified.\r\n\r\nCaring for patients with COVID-19 during the first wave of the pandemic was demanding because of a lack of knowledge about the disease and the severity of the illness. This led to ICU nurses experiencing extreme conditions that affected various aspects of their lives. Support from colleagues and teamwork were revealed to be particularly important for how nurses dealt with the demands of working during a pandemic, as was sufficient recovery time between work shifts.\r\n\r\nWork in ICUs was challenging and demanding, even before the pandemic. This study contributes to an understanding of the complex work environment that existed in hospitals during the first wave of the COVID-19 pandemic. The knowledge obtained from this study can be used to revise working conditions and identify health interventions for ICU nurses.", "doi": "10.1111/nicc.12931", "pmid": "37248953", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:09:43.513Z", "modified": "2023-10-04T06:07:09.604Z"}, {"entity": "publication", "iuid": "01ff4dc2353e4b8e8cb12a0ca6ed29a3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01ff4dc2353e4b8e8cb12a0ca6ed29a3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01ff4dc2353e4b8e8cb12a0ca6ed29a3"}}, "title": "The impact of the COVID-19 pandemic on adverse fetal outcomes: A cross-sectional study", "authors": [{"family": "Dageli\u0107", "given": "Andrea", "initials": "A", "orcid": "0000-0001-9374-652X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c003b74a9039488c988a6217611179d5.json"}}, {"family": "Mulic", "given": "Emma", "initials": "E"}, {"family": "Kuzmic Prusac", "given": "Ivana", "initials": "I"}, {"family": "Zekic Tomas", "given": "Sandra", "initials": "S"}], "type": "journal-article", "published": "2023-05-26", "journal": {"title": null, "issn": "0025-7974", "issn-l": null, "volume": "102", "issue": "21", "pages": "e33887"}, "abstract": null, "doi": "10.1097/md.0000000000033887", "pmid": null, "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:10:52.794Z", "modified": "2023-10-04T07:01:12.953Z"}, {"entity": "publication", "iuid": "7b561974f87c49d5ae37c5b8d9642013", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b561974f87c49d5ae37c5b8d9642013.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b561974f87c49d5ae37c5b8d9642013"}}, "title": "Nucleocapsid-specific T cell responses associate with control of SARS-CoV-2 in the upper airways before seroconversion.", "authors": [{"family": "Eser", "given": "Tabea M", "initials": "TM"}, {"family": "Baranov", "given": "Olga", "initials": "O"}, {"family": "Huth", "given": "Manuel", "initials": "M"}, {"family": "Ahmed", "given": "Mohammed I M", "initials": "MIM"}, {"family": "De\u00e1k", "given": "Flora", "initials": "F"}, {"family": "Held", "given": "Kathrin", "initials": "K", "orcid": "0000-0001-7057-6935", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f231ea9496f44e7583759b1bfb4ebdc1.json"}}, {"family": "Lin", "given": "Luming", "initials": "L"}, {"family": "Pekayvaz", "given": "Kami", "initials": "K", "orcid": "0000-0003-4040-650X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4eca6461e96449888f127c3fdb1c32ea.json"}}, {"family": "Leunig", "given": "Alexander", "initials": "A", "orcid": "0000-0002-9179-9203", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a485b7ea41942dc93c9b97f7606a207.json"}}, {"family": "Nicolai", "given": "Leo", "initials": "L", "orcid": "0000-0003-0776-5885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea251a7bafc44037b1e396bc701ee5ec.json"}}, {"family": "Pollakis", "given": "Georgios", "initials": "G", "orcid": "0000-0002-9659-5461", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e3c57acb0fe344d2b70287bf40755970.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}, {"family": "Price", "given": "David A", "initials": "DA", "orcid": "0000-0001-9416-2737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/734b7fd55fca47f8b00d1281331ef39a.json"}}, {"family": "Rubio-Acero", "given": "Raquel", "initials": "R"}, {"family": "Reich", "given": "Jakob", "initials": "J"}, {"family": "Falk", "given": "Philine", "initials": "P"}, {"family": "Markgraf", "given": "Alissa", "initials": "A"}, {"family": "Puchinger", "given": "Kerstin", "initials": "K"}, {"family": "Castelletti", "given": "Noemi", "initials": "N"}, {"family": "Olbrich", "given": "Laura", "initials": "L"}, {"family": "Vanshylla", "given": "Kanika", "initials": "K"}, {"family": "Klein", "given": "Florian", "initials": "F", "orcid": "0000-0003-1376-1792", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc5736c1f6d84545aedc698ba8923b72.json"}}, {"family": "Wieser", "given": "Andreas", "initials": "A"}, {"family": "Hasenauer", "given": "Jan", "initials": "J", "orcid": "0000-0002-4935-3312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e7be5dc819640ff93da1f6e76ef6998.json"}}, {"family": "Kroidl", "given": "Inge", "initials": "I"}, {"family": "Hoelscher", "given": "Michael", "initials": "M"}, {"family": "Geldmacher", "given": "Christof", "initials": "C"}], "type": "journal article", "published": "2023-05-24", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "14", "issue": "1", "pages": "2952"}, "abstract": "Despite intensive research since the emergence of SARS-CoV-2, it has remained unclear precisely which components of the early immune response protect against the development of severe COVID-19. Here, we perform a comprehensive immunogenetic and virologic analysis of nasopharyngeal and peripheral blood samples obtained during the acute phase of infection with SARS-CoV-2. We find that soluble and transcriptional markers of systemic inflammation peak during the first week after symptom onset and correlate directly with upper airways viral loads (UA-VLs), whereas the contemporaneous frequencies of circulating viral nucleocapsid (NC)-specific CD4+ and CD8+ T cells correlate inversely with various inflammatory markers and UA-VLs. In addition, we show that high frequencies of activated CD4+ and CD8+ T cells are present in acutely infected nasopharyngeal tissue, many of which express genes encoding various effector molecules, such as cytotoxic proteins and IFN-\u03b3. The presence of IFNG mRNA-expressing CD4+ and CD8+ T cells in the infected epithelium is further linked with common patterns of gene expression among virus-susceptible target cells and better local control of SARS-CoV-2. Collectively, these results identify an immune correlate of protection against SARS-CoV-2, which could inform the development of more effective vaccines to combat the acute and chronic illnesses attributable to COVID-19.", "doi": "10.1038/s41467-023-38020-8", "pmid": "37225706", "labels": {"Category: Proteins": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10209201"}, {"db": "pii", "key": "10.1038/s41467-023-38020-8"}], "notes": [], "created": "2023-10-04T05:08:42.239Z", "modified": "2023-10-04T05:19:11.862Z"}, {"entity": "publication", "iuid": "74d814ab0f594337b2c3250af3cb3500", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/74d814ab0f594337b2c3250af3cb3500.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/74d814ab0f594337b2c3250af3cb3500"}}, "title": "Association between SARS-CoV-2 infection and newly diagnosed hypertension during pregnancy: prospective, population based cohort study.", "authors": [{"family": "\u00d6rtqvist", "given": "Anne K", "initials": "AK", "orcid": "0000-0001-9019-9233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7bfdbeb2a2d848ec928a6c7f7d112465.json"}}, {"family": "Magnus", "given": "Maria C", "initials": "MC"}, {"family": "Dahlqvist", "given": "Elisabeth", "initials": "E"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Johansson", "given": "Kari", "initials": "K", "orcid": "0000-0002-1497-3079", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f592ab7cb9645098896efc10bee41c4.json"}}, {"family": "Sandstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}, {"family": "Stephansson", "given": "Olof", "initials": "O", "orcid": "0000-0003-1528-4563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39af50356a574c80ba6bd2227ecb5cf5.json"}}], "type": "journal article", "published": "2023-05-24", "journal": {"title": "BMJ Med", "issn": "2754-0413", "issn-l": null, "volume": "2", "issue": "1", "pages": "e000465"}, "abstract": "To study the association between SARS-CoV-2 infection and newly diagnosed hypertension during pregnancy.\r\n\r\nProspective, population based cohort study.\r\n\r\nAll singleton pregnancies after 22 completed gestational weeks registered in the Swedish Pregnancy Register and the Medical Birth Registry of Norway, from 1 March 2020 to 24 May 2022.\r\n\r\n312 456 individuals available for analysis (201 770 in Sweden and 110 686 in Norway), with pregnancies that reached 42 completed gestational weeks by the end of follow-up in the pregnancy registries, excluding individuals with SARS-CoV-2 infection before pregnancy and those with a diagnosis of pre-existing hypertension or onset of hypertension before 20 gestational weeks.\r\n\r\nNewly diagnosed hypertension during pregnancy was defined as a composite outcome of a diagnosis of gestational hypertension, pre-eclampsia, HELLP (haemolysis, elevated liver enzymes, low platelets) syndrome, or eclampsia, from gestational week 20 to one week after delivery. The association between SARS-CoV-2 infection and hypertension during pregnancy was investigated with a stratified Cox proportional hazard model, adjusting for maternal age, body mass index, parity, smoking, region of birth, education, income, coexisting medical conditions, previous hypertension during pregnancy, number of healthcare visits during the past year, and vaccination against SARS-CoV-2. Pre-eclampsia was also analysed as a separate outcome.\r\n\r\nOf 312 456 individuals available for analysis, 8% (n=24 566) had SARS-CoV-2 infection any time during pregnancy, 6% (n=18 051) had a diagnosis of hypertension during pregnancy, and 3% (9899) had pre-eclampsia. SARS-CoV-2 infection during pregnancy was not associated with an increased risk of hypertension during pregnancy (adjusted hazard ratio 0.99, 95% confidence interval 0.93 to 1.04) or pre-eclampsia (0.98, 0.87 to 1.10). The results were similar for SARS-CoV-2 infection in all gestational trimesters and in different time periods that corresponded to dominance of different variants of the SARS-CoV-2 virus.\r\n\r\nThis population based study did not find any evidence of an association between SARS-CoV-2 infection during pregnancy and an increased risk of hypertension during pregnancy or pre-eclampsia.", "doi": "10.1136/bmjmed-2022-000465", "pmid": "37275554", "labels": {"Category: Health": null, "Funder: H2020": null, "Funder: NordForsk": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10230329"}, {"db": "pii", "key": "bmjmed-2022-000465"}], "notes": [], "created": "2023-10-04T09:31:57.973Z", "modified": "2023-10-04T10:59:41.792Z"}, {"entity": "publication", "iuid": "a41b6cfc55034bb69940f6ea84543eda", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a41b6cfc55034bb69940f6ea84543eda.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a41b6cfc55034bb69940f6ea84543eda"}}, "title": "Insomnia and job stressors among healthcare workers who served COVID-19 patients in Bangladesh.", "authors": [{"family": "Rahman", "given": "Farzana", "initials": "F"}, {"family": "Dalal", "given": "Koustuv", "initials": "K"}, {"family": "Hasan", "given": "Mehedi", "initials": "M"}, {"family": "Islam", "given": "Tariful", "initials": "T"}, {"family": "Tuli", "given": "Samiha Nahar", "initials": "SN"}, {"family": "Akter", "given": "Asma", "initials": "A"}, {"family": "Tanvir", "given": "K M", "initials": "KM"}, {"family": "Islam", "given": "Khairul", "initials": "K"}, {"family": "Rahman", "given": "Ashikur", "initials": "A"}, {"family": "Nabi", "given": "Mohammad Hayatun", "initials": "MH"}, {"family": "Rahman", "given": "Mohammad Lutfor", "initials": "ML"}, {"family": "Hossain Hawlader", "given": "Mohammad Delwer", "initials": "MD"}], "type": "journal article", "published": "2023-05-23", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "issn-l": null, "volume": "23", "issue": "1", "pages": "523"}, "abstract": "The global outbreak of COVID-19 has created unprecedented havoc among health care workers, resulting in significant psychological strains like insomnia. This study aimed to analyze insomnia prevalence and job stressors among Bangladeshi health care workers in COVID-19 units.\r\n\r\nWe conducted this cross-sectional study to assess insomnia severity from January to March 2021 among 454 health care workers working in multiple hospitals in Dhaka city with active COVID-dedicated units. We selected 25 hospitals conveniently. We used a structured questionnaire for face-to-face interviews containing sociodemographic variables and job stressors. The severity of insomnia was measured by the Insomnia Severity Scale (ISS). The scale has seven items to evaluate the rate of insomnia, which was categorized as the absence of Insomnia (0-7); sub-threshold Insomnia (8-14); moderate clinical Insomnia (15-21); and severe clinical Insomnia (22-28). To identify clinical insomnia, a cut-off value of 15 was decided primarily. A cut-off score of 15 was initially proposed for identifying clinical insomnia. We performed a chi-square test and adjusted logistic regression to explore the association of different independent variables with clinically significant insomnia using the software SPSS version 25.0.\r\n\r\n61.5% of our study participants were females. 44.9% were doctors, 33.9% were nurses, and 21.1% were other health care workers. Insomnia was more dominant among doctors and nurses (16.2% and 13.6%, respectively) than others (4.2%). We found clinically significant insomnia was associated with several job stressors (p < 0.05). In binary logistic regression, having sick leave (OR = 0.248, 95% CI = 0.116, 0.532) and being entitled to risk allowance (OR = 0.367, 95% CI = 0.124.1.081) showed lower odds of developing Insomnia. Previously diagnosed with COVID-19-positive health care workers had an OR of 2.596 (95% CI = 1.248, 5.399), pointing at negative experiences influencing insomnia. In addition, we observed that any training on risk and hazard increased the chances of suffering from Insomnia (OR = 1.923, 95% CI = 0.934, 3.958).\r\n\r\nIt is evident from the findings that the volatile existence and ambiguity of COVID-19 have induced significant adverse psychological effects and subsequently directed our HCWs toward disturbed sleep and insomnia. The study recommends the imperativeness to formulate and implement collaborative interventions to help HCWs cope with this crisis and mitigate the mental stresses they experience during the pandemic.", "doi": "10.1186/s12913-023-09464-x", "pmid": "37221591", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10204693"}, {"db": "pii", "key": "10.1186/s12913-023-09464-x"}], "notes": [], "created": "2023-10-04T05:10:58.106Z", "modified": "2023-10-04T07:02:39.981Z"}, {"entity": "publication", "iuid": "7e426d44c7a94201b356d6ffe6de95e6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e426d44c7a94201b356d6ffe6de95e6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e426d44c7a94201b356d6ffe6de95e6"}}, "title": "Clustering Analysis Identified Three Long COVID Phenotypes and Their Association with General Health Status and Working Ability.", "authors": [{"family": "Kisiel", "given": "Marta A", "initials": "MA"}, {"family": "Lee", "given": "Seika", "initials": "S"}, {"family": "Malmquist", "given": "Sara", "initials": "S", "orcid": "0009-0002-1404-9721", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2beb89d6d65143b1b212af06fd5315ea.json"}}, {"family": "Rykatkin", "given": "Oliver", "initials": "O"}, {"family": "Holgert", "given": "Sebastian", "initials": "S"}, {"family": "Janols", "given": "Helena", "initials": "H"}, {"family": "Janson", "given": "Christer", "initials": "C"}, {"family": "Zhou", "given": "Xingwu", "initials": "X", "orcid": "0000-0002-9831-9102", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9497b3ea54cc45be9ee3e7fe596b184c.json"}}], "type": "journal article", "published": "2023-05-23", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "12", "issue": "11", "pages": null}, "abstract": "This study aimed to distinguish different phenotypes of long COVID through the post-COVID syndrome (PCS) score based on long-term persistent symptoms following COVID-19 and evaluate whether these symptoms affect general health and work ability. In addition, the study identified predictors for severe long COVID.\r\n\r\nThis cluster analysis included cross-sectional data from three cohorts of patients after COVID-19: non-hospitalized (n = 401), hospitalized (n = 98) and those enrolled at the post-COVID outpatient's clinic (n = 85). All the subjects responded to the survey on persistent long-term symptoms and sociodemographic and clinical factors. K-Means cluster analysis and ordinal logistic regression were used to create PCS scores that were used to distinguish patients' phenotypes.\r\n\r\n506 patients with complete data on persistent symptoms were divided into three distinct phenotypes: none/mild (59%), moderate (22%) and severe (19%). The patients with severe phenotype, with the predominating symptoms were fatigue, cognitive impairment and depression, had the most reduced general health status and work ability. Smoking, snuff, body mass index (BMI), diabetes, chronic pain and symptom severity at COVID-19 onset were factors predicting severe phenotype.\r\n\r\nThis study suggested three phenotypes of long COVID, where the most severe was associated with the highest impact on general health status and working ability. This knowledge on long COVID phenotypes could be used by clinicians to support their medical decisions regarding prioritizing and more detailed follow-up of some patient groups.", "doi": "10.3390/jcm12113617", "pmid": "37297812", "labels": {"Category: Social Science & Humanities": null, "Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10253616"}, {"db": "pii", "key": "jcm12113617"}], "notes": [], "created": "2023-10-04T09:31:36.523Z", "modified": "2023-10-04T10:50:11.813Z"}, {"entity": "publication", "iuid": "8c1fa59dc74846e69add24cb8640bd11", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c1fa59dc74846e69add24cb8640bd11.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c1fa59dc74846e69add24cb8640bd11"}}, "title": "The risk for celiac disease after Covid-19 infection.", "authors": [{"family": "Lexner", "given": "Jesper", "initials": "J"}, {"family": "Lindroth", "given": "Ylva", "initials": "Y"}, {"family": "Sj\u00f6berg", "given": "Klas", "initials": "K"}], "type": "journal article", "published": "2023-05-22", "journal": {"title": "BMC Gastroenterol", "issn": "1471-230X", "issn-l": null, "volume": "23", "issue": "1", "pages": "174"}, "abstract": "Celiac disease (CD) is an autoimmune disease leading to gastrointestinal symptoms and mineral deficiencies. The pathogenetic mechanisms, besides the clear HLA association, are elusive. Among environmental factors infections have been proposed. Covid-19 infection results in a systemic inflammatory response that often also involves the gastrointestinal tract. The aim of the present study was to investigate whether Covid-19 infection could increase the risk for CD.\r\n\r\nAll patients, both children and adults, in the county Sk\u00e5ne (1.4 million citizens) in southern Sweden with newly diagnosed biopsy- or serology-verified CD or a positive tissue transglutaminase antibody test (tTG-ab) during 2016-2021 were identified from registries at the Departments of Pathology and Immunology, respectively. Patients with a positive Covid-19 PCR or antigen test in 2020 and 2021 were identified from the Public Health Agency of Sweden.\r\n\r\nDuring the Covid-19 pandemic (March 2020 - December 2021), there were 201 050 cases of Covid-19 and 568 patients with biopsy- or serology-verified CD or a first-time positive tTG-ab tests, of which 35 patients had been infected with Covid-19 before CD. The incidence of verified CD and tTG-ab positivity was lower in comparison to before the pandemic (May 2018 - February 2020; 22.5 vs. 25.5 cases per 100 000 person-years, respectively, incidence rate difference (IRD) -3.0, 95% CI -5.7 - -0.3, p = 0.028). The incidence of verified CD and tTG-ab positivity in patients with and without prior Covid-19 infection was 21.1 and 22.4 cases per 100 000 person-years, respectively (IRD - 1.3, 95% CI -8.5-5.9, p = 0.75).\r\n\r\nOur results indicate that Covid-19 is not a risk factor for CD development. While gastrointestinal infections seem to be an important part of the CD pathogenesis, respiratory infections probably are of less relevance.", "doi": "10.1186/s12876-023-02795-3", "pmid": "37217874", "labels": {"Category: Serology": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10202072"}, {"db": "pii", "key": "10.1186/s12876-023-02795-3"}], "notes": [], "created": "2023-10-04T05:09:38.514Z", "modified": "2023-10-04T06:04:13.447Z"}, {"entity": "publication", "iuid": "f755a5acb7b34b63ad7d93b44e2f29eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f755a5acb7b34b63ad7d93b44e2f29eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f755a5acb7b34b63ad7d93b44e2f29eb"}}, "title": "Serum IL-23, IL-10, and TNF-\u03b1 predict in-hospital mortality in COVID-19 patients.", "authors": [{"family": "Smail", "given": "Shukur Wasman", "initials": "SW"}, {"family": "Babaei", "given": "Esmaeil", "initials": "E"}, {"family": "Amin", "given": "Kawa", "initials": "K"}, {"family": "Abdulahad", "given": "Wayel H", "initials": "WH"}], "type": "journal article", "published": "2023-05-22", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "1145840"}, "abstract": "The hyperinflammatory response, caused by severe acute respiratory syndrome-2 (SARS-CoV-2), is the most common cause of death in patients with coronavirus disease 2019 (COVID-19). The etiopathogenesis of this illness is not fully understood. Macrophages appear to play a key part in COVID-19's pathogenic effects. Therefore, this study aims to examine serum inflammatory cytokines associated with the activation state of macrophages in COVID-19 patients and attempt to find accurate predictive markers for disease severity and mortality risk in hospital.\r\n\r\n180 patients with COVID-19 and 90 healthy controls (HCs) participated in this study. Patients were divided into three different subgroups, mild (n=81), severe (n=60), and critical groups (n=39). Serum samples were collected and IL (Interleukin)-10, IL-23, tumor necrosis factor-alpha (TNF-\u03b1), interferon-gamma (IFN-\u03b3), IL-17, monocyte chemoattractant protein-1 (MCP-1) and chemokine ligand 3 (CCL3) were determined by ELISA. In parallel, myeloperoxidase (MPO) and C-reactive protein (CRP) were measured using colorimetric and electrochemiluminescence methods, respectively. Data were collected, and their associations with disease progression and mortality were assessed using regression models and receiver operating characteristic (ROC) curves.\r\n\r\nCompared to HCs, a significant increase in IL-23, IL-10, TNF-\u03b1, IFN-\u03b3 and MCP-1, were observed in COVID-19 patients. Serum levels of IL-23, IL-10, and TNF-\u03b1 were significantly higher in COVID-19 patients with critical cases compared to mild and severe cases, and correlated positively with CRP level. However, non-significant changes were found in serum MPO and CCL3 among the studied groups. Moreover, significant positive association has been observed among increased IL-10, IL-23 and TNF-\u03b1 in serum of COVID-19 patients. Furthermore, a binary logistic regression model was applied to predict death's independent factors. Results showed that IL-10 alone or in combination with IL23 and TNF-\u03b1 are strongly linked with non-survivors in COVID-19 patients. Finally, ROC curve results uncovered that IL-10, IL-23 and TNF-\u03b1 were excellent predictors for prognosing COVID-19.\r\n\r\nThe elevations of IL-10, IL-23, and TNF-\u03b1 levels were seen in severe and critical cases of COVID-19 patients and their elevations were linked to the in-hospital mortality of the disease. A prediction model shows that the determination of these cytokines upon admission is important and should be done on COVID-19 patients as a way of evaluating the prognosis of the disease. COVID-19 Patients with high IL-10, IL-23, and TNF-\u03b1 on admission are more likely to experience a severe form of the disease; therefore, those patients should be cautionary monitored and treated.", "doi": "10.3389/fimmu.2023.1145840", "pmid": "37283736", "labels": {"Category: Biochemistry": null, "Category: Serology": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10239952"}], "notes": [], "created": "2023-10-04T09:30:09.738Z", "modified": "2023-10-04T09:50:07.803Z"}, {"entity": "publication", "iuid": "e84173f451f64b809dc0a626971777c8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e84173f451f64b809dc0a626971777c8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e84173f451f64b809dc0a626971777c8"}}, "title": "Staff quality of working life and turnover intentions in municipal nursing care and social welfare: a cross-sectional study.", "authors": [{"family": "Engstr\u00f6m", "given": "Maria", "initials": "M", "orcid": "0000-0002-9912-5350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5497902ecdbb4df0a2678becfdb2678b.json"}}, {"family": "Jarnheden", "given": "Sofia Hanberger", "initials": "SH", "orcid": "0000-0003-4864-2400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/802cfff423144af39472f93e1dd5af5f.json"}}, {"family": "Tham", "given": "Pia", "initials": "P", "orcid": "0000-0003-4155-810X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8544cc6baab44c1c8a8d4fc86653c70f.json"}}], "type": "journal article", "published": "2023-05-19", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "issn-l": null, "volume": "22", "issue": "1", "pages": "171"}, "abstract": "Nurses and social workers are two common professions with a university degree working within municipal nursing care and social welfare. Both groups have high turnover intention rates, and there is a need to better understand their quality of working life and turnover intentions in general and more specifically during the Covid-19 pandemic. This study investigated associations between working life, coping strategies and turnover intentions of staff with a university degree working within municipal care and social welfare during the Covid-19 pandemic.\r\n\r\nA cross-sectional design; 207 staff completed questionnaires and data were analyzed using multiple linear regression analyses.\r\n\r\nTurnover intentions were common. For registered nurses 23% thought of leaving the workplace and 14% the profession 'rather often' and 'very often/always'. The corresponding figures for social workers were 22% (workplace) and 22% (profession). Working life variables explained 34-36% of the variance in turnover intentions. Significant variables in the multiple linear regression models were work-related stress, home-work interface and job-career satisfaction (both for the outcome turnover intentions profession and workplace) and Covid-19 exposure/patients (turnover intentions profession). For the chosen coping strategies, 'exercise', 'recreation and relaxation' and 'improving skills', the results (associations with turnover) were non-significant. However, comparing the groups social workers reported that they used 'recreation and relaxation' more often than were reported by registered nurses.\r\n\r\nMore work-related stress, worse home-work interface and less job-career satisfaction together with Covid-19 exposure/patients (Covid-19 only for turnover profession) increase turnover intentions. Recommendations are that managers should strive for better home-work interface and job-career satisfaction, monitor and counteract work-related stress to prevent turnover intentions.", "doi": "10.1186/s12912-023-01339-0", "pmid": "37202759", "labels": {"Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10195664"}, {"db": "pii", "key": "10.1186/s12912-023-01339-0"}], "notes": [], "created": "2023-10-04T05:09:54.134Z", "modified": "2023-10-04T06:22:41.430Z"}, {"entity": "publication", "iuid": "3f935702fdea4236995c2f3e832343d1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f935702fdea4236995c2f3e832343d1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f935702fdea4236995c2f3e832343d1"}}, "title": "Detoxified synthetic bacterial membrane vesicles as a vaccine platform against bacteria and SARS-CoV-2.", "authors": [{"family": "Park", "given": "Kyong-Su", "initials": "K"}, {"family": "Svennerholm", "given": "Kristina", "initials": "K"}, {"family": "Crescitelli", "given": "Rossella", "initials": "R"}, {"family": "L\u00e4sser", "given": "Cecilia", "initials": "C"}, {"family": "Gribonika", "given": "Inta", "initials": "I"}, {"family": "Andersson", "given": "Mickael", "initials": "M"}, {"family": "Bostr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Alalam", "given": "Hanna", "initials": "H"}, {"family": "Harandi", "given": "Ali M", "initials": "AM"}, {"family": "Farewell", "given": "Anne", "initials": "A"}, {"family": "L\u00f6tvall", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2023-05-19", "journal": {"title": "J Nanobiotechnology", "issn": "1477-3155", "issn-l": null, "volume": "21", "issue": "1", "pages": "156"}, "abstract": "The development of vaccines based on outer membrane vesicles (OMV) that naturally bud off from bacteria is an evolving field in infectious diseases. However, the inherent inflammatory nature of OMV limits their use as human vaccines. This study employed an engineered vesicle technology to develop synthetic bacterial vesicles (SyBV) that activate the immune system without the severe immunotoxicity of OMV. SyBV were generated from bacterial membranes through treatment with detergent and ionic stress. SyBV induced less inflammatory responses in macrophages and in mice compared to natural OMV. Immunization with SyBV or OMV induced comparable antigen-specific adaptive immunity. Specifically, immunization with Pseudomonas aeruginosa-derived SyBV protected mice against bacterial challenge, and this was accompanied by significant reduction in lung cell infiltration and inflammatory cytokines. Further, immunization with Escherichia coli-derived SyBV protected mice against E. coli sepsis, comparable to OMV-immunized group. The protective activity of SyBV was driven by the stimulation of B-cell and T-cell immunity. Also, SyBV were engineered to display the SARS-CoV-2 S1 protein on their surface, and these vesicles induced specific S1 protein antibody and T-cell responses. Collectively, these results demonstrate that SyBV may be a safe and efficient vaccine platform for the prevention of bacterial and viral infections.", "doi": "10.1186/s12951-023-01928-w", "pmid": "37208676", "labels": {"Funder: VR": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10196325"}, {"db": "pii", "key": "10.1186/s12951-023-01928-w"}], "notes": [], "created": "2023-10-04T05:12:11.703Z", "modified": "2023-10-04T08:12:16.374Z"}, {"entity": "publication", "iuid": "cdcd3ca0f01044869cd89862392e5e88", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cdcd3ca0f01044869cd89862392e5e88.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cdcd3ca0f01044869cd89862392e5e88"}}, "title": "Working conditions for healthcare workers at a Swedish university hospital infectious disease department during the COVID-19 pandemic: barriers and facilitators to maintaining employee wellbeing.", "authors": [{"family": "Veje", "given": "Malin", "initials": "M"}, {"family": "Linden", "given": "Karolina", "initials": "K"}, {"family": "Sengpiel", "given": "Verena", "initials": "V"}, {"family": "Carlsson", "given": "Ylva", "initials": "Y"}, {"family": "Jonsdottir", "given": "Ingibj\u00f6rg H", "initials": "IH"}, {"family": "Degl'Innocenti", "given": "Alessio", "initials": "A"}, {"family": "Ahlstrom", "given": "Linda", "initials": "L"}, {"family": "Wijk", "given": "Helle", "initials": "H"}, {"family": "Akerstrom", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2023-05-18", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "14", "issue": null, "pages": "1183084"}, "abstract": "Healthcare workers (HCWs) at infectious disease departments have held the frontline during the COVID-19 pandemic. This study aimed to identify barriers and facilitators to maintaining the employees' wellbeing that may be used to increase preparedness for future pandemics within ID Departments.\r\n\r\nIn September 2020, a web-based survey on demographics and work environment was distributed to all HCWs at the Infectious Disease Department at Sahlgrenska University Hospital. Results were compared with a pre-COVID-19 survey from October 2019. A quantitative analysis of the overall effects of the pandemic on the working conditions of HCWs was conducted; in addition, a qualitative content analysis of open-ended responses was performed.\r\n\r\nIn total, 222 and 149 HCWs completed the pre-COVID-19 and COVID-19 surveys (84 and 54% response rate), respectively. Overall, we found significant changes regarding increased workload, lack of emotional support in stressful work situations, and inability to recover after shifts. These factors correlated both with younger age and concern of becoming infected. The open-ended answers (n = 103, 69%) revealed five generic categories (Workload; Organizational support; Worry and ethical stress; Capability; and Cooperation and unity) with a total of 14 identified factors representing plausible individual and organizational-level barriers or facilitators to sustained employee wellbeing.\r\n\r\nYounger HCWs as well as those expressing worries about contracting the infection were found to be particularly affected during the COVID-19 pandemic and these groups may require additional support in future outbreaks. Factors both increasing and decreasing the pandemic-induced negative health consequences for HCWs were identified; this knowledge may be utilized in the future.", "doi": "10.3389/fpsyg.2023.1183084", "pmid": "37275708", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10233109"}], "notes": [], "created": "2023-10-04T09:31:06.907Z", "modified": "2023-10-04T10:43:01.107Z"}, {"entity": "publication", "iuid": "10db20243623418cb19d0d22385e71b6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/10db20243623418cb19d0d22385e71b6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/10db20243623418cb19d0d22385e71b6"}}, "title": "Vision impairment is common in non-hospitalised patients with post-COVID-19 syndrome.", "authors": [{"family": "Johansson", "given": "Jan", "initials": "J", "orcid": "0000-0002-1093-4179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92589deccb094908acfe20279eab5462.json"}}, {"family": "M\u00f6ller", "given": "Marika", "initials": "M", "orcid": "0000-0001-8700-5186", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cddc264c52e1464ea162c7d9146f9021.json"}}, {"family": "Markovic", "given": "Gabriela", "initials": "G", "orcid": "0000-0002-7500-9531", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e9609af7155478eb2c7cd90694c648e.json"}}, {"family": "Borg", "given": "Kristian", "initials": "K", "orcid": "0000-0001-8748-1772", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c78e26fb1a414c69834b7261e2f93dad.json"}}], "type": "journal article", "published": "2023-05-18", "journal": {"title": "Clin Exp Optom", "issn": "1444-0938", "issn-l": null, "volume": null, "issue": null, "pages": "1-8"}, "abstract": "Vision-related problems can be part of longstanding sequelae after COVID-19 and hamper the return to work and daily activities. Knowledge about symptoms, visual, and oculomotor dysfunctions is however scarce, particularly for non-hospitalised patients. Clinically applicable tools are needed as support in the assessment and determination of intervention needs.\r\n\r\nThe purpose of this study was to evaluate vision-related symptoms, assess visual and oculomotor function, and to test the clinical assessment of saccadic eye movements and sensitivity to visual motion in non-hospitalised post-COVID-19 outpatients. The patients (n = 38) in this observational cohort study were recruited from a post-COVID-19 clinic and had been referred for neurocognitive assessment.\r\n\r\nPatients who reported vision-related symptoms reading problems and intolerance to movement in the environment were examined. A structured symptom assessment and a comprehensive vision examination were undertaken, and saccadic eye movements and visual motion sensitivity were assessed.\r\n\r\nHigh symptom scores (26-60%) and prevalence of visual function impairments were observed. An increased symptom score when reading was associated with less efficient saccadic eye movement behaviour (p < 0.001) and binocular dysfunction (p = 0.029). Patients with severe symptoms in visually busy places scored significantly higher on the Visual Motion Sensitivity Clinical Test Protocol (p = 0.029).\r\n\r\nVision-related symptoms and impairments were prevalent in the study group. The Developmental Eye Movement Test and the Visual Motion Sensitivity Clinical Test Protocol showed promise for clinical assessment of saccadic performance and sensitivity to movement in the environment. Further study will be required to explore the utility of these tools.", "doi": "10.1080/08164622.2023.2213826", "pmid": "37201931", "labels": {"Category: Social Science & Humanities": null, "Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:10:45.543Z", "modified": "2023-10-04T06:57:42.564Z"}, {"entity": "publication", "iuid": "1ef0f962c9724dd284a6914a33072c9a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ef0f962c9724dd284a6914a33072c9a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ef0f962c9724dd284a6914a33072c9a"}}, "title": "Long COVID is primarily a Spike protein Induced Thrombotic Vasculitis", "authors": [{"family": "Kerr", "given": "Robin", "initials": "R", "orcid": "0000-0003-2480-2748", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72bb5381b3d84c7fa0de3fee9efbef73.json"}}, {"family": "Carroll", "given": "Harriet A", "initials": "HA", "orcid": "0000-0002-4998-4675", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/851010212d214d9091381760df4427e4.json"}}], "type": "posted-content", "published": "2023-05-18", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.21203/rs.3.rs-2939263/v1", "pmid": null, "labels": {"Category: Post-COVID": null, "Category: Proteins": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:08:39.096Z", "modified": "2023-10-04T05:17:34.352Z"}, {"entity": "publication", "iuid": "c2a2de1360d04408925c33cdb37d5443", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2a2de1360d04408925c33cdb37d5443.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2a2de1360d04408925c33cdb37d5443"}}, "title": "COVID-19 responses restricted abilities and aspirations for mobility and migration: insights from diverse cities in four continents.", "authors": [{"family": "Jolivet", "given": "Dominique", "initials": "D"}, {"family": "Fransen", "given": "Sonja", "initials": "S", "orcid": "0000-0002-7709-4418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/974425d862624044868ef165bca12048.json"}}, {"family": "Adger", "given": "William Neil", "initials": "WN", "orcid": "0000-0003-4244-2854", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c8a100ec8be42b7bb612dcb9f9ef6ab.json"}}, {"family": "F\u00e1bos", "given": "Anita", "initials": "A", "orcid": "0000-0001-6178-6439", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d17ce3e46d3645dfa4caf5012d4d6499.json"}}, {"family": "Abu", "given": "Mumuni", "initials": "M"}, {"family": "Allen", "given": "Charlotte", "initials": "C"}, {"family": "Boyd", "given": "Emily", "initials": "E", "orcid": "0000-0002-1643-9718", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ad7922a45d94ca2b93584b4835ab1f4.json"}}, {"family": "Carr", "given": "Edward R", "initials": "ER", "orcid": "0000-0001-7784-471X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ac45aa9461b4a42b481371372941be6.json"}}, {"family": "Codjoe", "given": "Samuel Nii Ardey", "initials": "SNA"}, {"family": "Gavonel", "given": "Maria Franco", "initials": "MF", "orcid": "0000-0003-2377-5987", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a3bea59d3fa4acc95f7ec4e9487fa7f.json"}}, {"family": "Gemenne", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Rocky", "given": "Mahmudol Hasan", "initials": "MH"}, {"family": "Lantz", "given": "Jozefina", "initials": "J"}, {"family": "Maculule", "given": "Domingos", "initials": "D"}, {"family": "de Campos", "given": "Ricardo Safra", "initials": "RS"}, {"family": "Siddiqui", "given": "Tasneem", "initials": "T"}, {"family": "Zickgraf", "given": "Caroline", "initials": "C"}], "type": "journal article", "published": "2023-05-18", "journal": {"title": "Humanit Soc Sci Commun", "issn": "2662-9992", "issn-l": null, "volume": "10", "issue": "1", "pages": "250"}, "abstract": "Research on the impacts of COVID-19 on mobility has focused primarily on the increased health vulnerabilities of involuntary migrant and displaced populations. But virtually all migration flows have been truncated and altered because of reduced economic and mobility opportunities of migrants. Here we use a well-established framework of migration decision-making, whereby individual decisions combine the aspiration and ability to migrate, to explain how public responses to the COVID-19 pandemic alter migration patterns among urban populations across the world. The principal responses to COVID-19 pandemic that affected migration are: 1) through travel restrictions and border closures, 2) by affecting abilities to move through economic and other means, and 3) by affecting aspirations to move. Using in-depth qualitative data collected in six cities in four continents (Accra, Amsterdam, Brussels, Dhaka, Maputo, and Worcester), we explore how populations with diverse levels of education and occupations were affected in their current and future mobility decisions. We use data from interviews with sample of internal and international migrants and non-migrants during the 2020 COVID-19 pandemic outbreak to identify the mechanisms through which the pandemic affected their mobility decisions. The results show common processes across the different geographical contexts: individuals perceived increased risks associated with further migration, which affected their migration aspirations, and had reduced abilities to migrate, all of which affected their migration decision-making processes. The results also reveal stark differences in perceived and experienced migration decision-making across precarious migrant groups compared to high-skilled and formally employed international migrants in all settings. This precarity of place is particularly evident in low-income marginalised populations.", "doi": "10.1057/s41599-023-01721-y", "pmid": "37250294", "labels": {"Funder: H2020": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10195652"}, {"db": "pii", "key": "1721"}], "notes": [], "created": "2023-10-04T05:11:03.101Z", "modified": "2023-10-04T07:05:57.264Z"}, {"entity": "publication", "iuid": "c44cf098ca084ba9a279d94f886e5650", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c44cf098ca084ba9a279d94f886e5650.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c44cf098ca084ba9a279d94f886e5650"}}, "title": "Telemedicine for diabetes management during COVID-19: what we have learnt, what and how to implement.", "authors": [{"family": "Rosta", "given": "Laszlo", "initials": "L"}, {"family": "Menyhart", "given": "Adrienn", "initials": "A"}, {"family": "Mahmeed", "given": "Wael Al", "initials": "WA"}, {"family": "Al-Rasadi", "given": "Khalid", "initials": "K"}, {"family": "Al-Alawi", "given": "Kamila", "initials": "K"}, {"family": "Banach", "given": "Maciej", "initials": "M"}, {"family": "Banerjee", "given": "Yajnavalka", "initials": "Y"}, {"family": "Ceriello", "given": "Antonio", "initials": "A"}, {"family": "Cesur", "given": "Mustafa", "initials": "M"}, {"family": "Cosentino", "given": "Francesco", "initials": "F"}, {"family": "Firenze", "given": "Alberto", "initials": "A"}, {"family": "Galia", "given": "Massimo", "initials": "M"}, {"family": "Goh", "given": "Su-Yen", "initials": "S"}, {"family": "Janez", "given": "Andrej", "initials": "A"}, {"family": "Kalra", "given": "Sanjay", "initials": "S"}, {"family": "Kapoor", "given": "Nitin", "initials": "N"}, {"family": "Lessan", "given": "Nader", "initials": "N"}, {"family": "Lotufo", "given": "Paulo", "initials": "P"}, {"family": "Papanas", "given": "Nikolaos", "initials": "N"}, {"family": "Rizvi", "given": "Ali A", "initials": "AA"}, {"family": "Sahebkar", "given": "Amirhossein", "initials": "A"}, {"family": "Santos", "given": "Raul D", "initials": "RD"}, {"family": "Stoian", "given": "Anca Pantea", "initials": "AP"}, {"family": "Toth", "given": "Peter P", "initials": "PP"}, {"family": "Viswanathan", "given": "Vijay", "initials": "V"}, {"family": "Kempler", "given": "Peter", "initials": "P"}, {"family": "Rizzo", "given": "Manfredi", "initials": "M"}], "type": "journal article", "published": "2023-05-17", "journal": {"title": "Front Endocrinol (Lausanne)", "issn": "1664-2392", "issn-l": null, "volume": "14", "issue": null, "pages": "1129793"}, "abstract": "The past two decades have witnessed telemedicine becoming a crucial part of health care as a method to facilitate doctor-patient interaction. Due to technological developments and the incremental acquisition of experience in its use, telemedicine's advantages and cost-effectiveness has led to it being recognised as specifically relevant to diabetology. However, the pandemic created new challenges for healthcare systems and the rate of development of digital services started to grow exponentially. It was soon discovered that COVID-19-infected patients with diabetes had an increased risk of both mortality and debilitating sequelae. In addition, it was observed that this higher risk could be attenuated primarily by maintaining optimal control of the patient's glucose metabolism. As opportunities for actual physical doctor-patient visits became restricted, telemedicine provided the most convenient opportunity to communicate with patients and maintain delivery of care. The wide range of experiences of health care provision during the pandemic has led to the development of several excellent strategies regarding the applicability of telemedicine across the whole spectrum of diabetes care. The continuation of these strategies is likely to benefit clinical practice even after the pandemic crisis is over.", "doi": "10.3389/fendo.2023.1129793", "pmid": "37265696", "labels": {"Category: Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC10231679"}], "notes": [], "created": "2023-10-04T09:33:13.651Z", "modified": "2023-10-04T11:20:33.345Z"}, {"entity": "publication", "iuid": "316bc4a243ca4651b3b53d1cd380f377", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/316bc4a243ca4651b3b53d1cd380f377.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/316bc4a243ca4651b3b53d1cd380f377"}}, "title": "Ultra-Processed Food vs. Fruit and Vegetable Consumption before and during the COVID-19 Pandemic among Greek and Swedish Students.", "authors": [{"family": "Dhammawati", "given": "Friska", "initials": "F"}, {"family": "Fagerberg", "given": "Petter", "initials": "P"}, {"family": "Diou", "given": "Christos", "initials": "C", "orcid": "0000-0002-2461-1928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73e37fdd544145f7a09e5d09a91a3408.json"}}, {"family": "Mavrouli", "given": "Ioanna", "initials": "I"}, {"family": "Koukoula", "given": "Evangelia", "initials": "E"}, {"family": "Lekka", "given": "Eirini", "initials": "E"}, {"family": "Stefanopoulos", "given": "Leandros", "initials": "L", "orcid": "0000-0002-2682-5639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff30bac728204c79adb77b08c9f6c0bc.json"}}, {"family": "Maglaveras", "given": "Nicos", "initials": "N", "orcid": "0000-0002-4919-0664", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02ae3a48f10d4c60971b80f807381fe1.json"}}, {"family": "Heimeier", "given": "Rachel", "initials": "R", "orcid": "0000-0003-4798-1312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0e753a7fa1047a484f8abb065cda4a8.json"}}, {"family": "Karavidopoulou", "given": "Youla", "initials": "Y", "orcid": "0000-0003-3648-9533", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4df84c2905245249ae478b9fbb99124.json"}}, {"family": "Ioakimidis", "given": "Ioannis", "initials": "I"}], "type": "journal article", "published": "2023-05-16", "journal": {"title": "Nutrients", "issn": "2072-6643", "issn-l": null, "volume": "15", "issue": "10", "pages": null}, "abstract": "The COVID-19 pandemic has impacted children's lifestyles, including dietary behaviors. Of particular concern among these behaviors is the heightened prevalence of ultra-processed food (UPF) consumption, which has been linked to the development of obesity and related non-communicable diseases. The present study examines the changes in (1) UPF and (2) vegetable and/or fruit consumption among school-aged children in Greece and Sweden before and during the COVID-19 pandemic.\r\n\r\nThe analyzed dataset consisted of main meal pictures (breakfast, lunch, and dinner) captured by 226 Greek students (94 before the pandemic and 132 during the pandemic) and 421 Swedish students (293 before and 128 during the pandemic), aged 9-18, who voluntarily reported their meals using a mobile application. The meal pictures were collected over four-month periods over two consecutive years; namely, between the 20th of August and the 20th of December in 2019 (before the COVID-19 outbreak) and the same period in 2020 (during the COVID-19 outbreak). The collected pictures were annotated manually by a trained nutritionist. A chi-square test was performed to evaluate the differences in proportions before versus during the pandemic.\r\n\r\nIn total, 10,770 pictures were collected, including 6474 pictures from before the pandemic and 4296 pictures collected during the pandemic. Out of those, 86 pictures were excluded due to poor image quality, and 10,684 pictures were included in the final analyses (4267 pictures from Greece and 6417 pictures from Sweden). The proportion of UPF significantly decreased during vs. before the pandemic in both populations (50% vs. 46%, p = 0.010 in Greece, and 71% vs. 66%, p < 0.001 in Sweden), while the proportion of vegetables and/or fruits significantly increased in both cases (28% vs. 35%, p < 0.001 in Greece, and 38% vs. 42%, p = 0.019 in Sweden). There was a proportional increase in meal pictures containing UPF among boys in both countries. In Greece, both genders showed an increase in vegetables and/or fruits, whereas, in Sweden, the increase in fruit and/or vegetable consumption was solely observed among boys.\r\n\r\nThe proportion of UPF in the Greek and Swedish students' main meals decreased during the COVID-19 pandemic vs. before the pandemic, while the proportion of main meals with vegetables and/or fruits increased.", "doi": "10.3390/nu15102321", "pmid": "37242204", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10222979"}, {"db": "pii", "key": "nu15102321"}], "notes": [], "created": "2023-10-04T05:11:00.506Z", "modified": "2023-10-04T07:04:21.238Z"}, {"entity": "publication", "iuid": "1535d377dc0043e6915cc2128df2a520", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1535d377dc0043e6915cc2128df2a520.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1535d377dc0043e6915cc2128df2a520"}}, "title": "Cardiorespiratory dysautonomia in post-COVID-19 condition: Manifestations, mechanisms and management.", "authors": [{"family": "Fedorowski", "given": "Artur", "initials": "A"}, {"family": "Ols\u00e9n", "given": "Monika Fagevik", "initials": "MF"}, {"family": "Nikesj\u00f6", "given": "Frida", "initials": "F"}, {"family": "Janson", "given": "Christer", "initials": "C", "orcid": "0000-0001-5093-6980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba296cda8ef74430ad5457e71b7dae94.json"}}, {"family": "Bruchfeld", "given": "Judith", "initials": "J"}, {"family": "Lerm", "given": "Maria", "initials": "M", "orcid": "0000-0002-5092-9892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a326e1fb7efa4c4f8f59e7572f6b83bc.json"}}, {"family": "Hedman", "given": "Kristofer", "initials": "K", "orcid": "0000-0002-3751-7180", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30b778f33408413eaf0cce6023e9dfa3.json"}}], "type": "journal article", "published": "2023-05-14", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "A significant proportion of COVID-19 patients experience debilitating symptoms for months after the acute infection. According to recent estimates, approximately 1 out of 10 COVID-19 convalescents reports persistent health issues more than 3 months after initial recovery. This 'post-COVID-19 condition' may include a large variety of symptoms from almost all domains and organs, and for some patients it may mean prolonged sick-leave, homestay and strongly limited activities of daily life. In this narrative review, we focus on the symptoms and signs of post-COVID-19 condition in adults - particularly those associated with cardiovascular and respiratory systems, such as postural orthostatic tachycardia syndrome or airway disorders - and explore the evidence for chronic autonomic dysfunction as a potential underlying mechanism. The most plausible hypotheses regarding cellular and molecular mechanisms behind the wide spectrum of observed symptoms - such as lingering viruses, persistent inflammation, impairment in oxygen sensing systems and circulating antibodies directed to blood pressure regulatory components - are discussed. In addition, an overview of currently available pharmacological and non-pharmacological treatment options is presented.", "doi": "10.1111/joim.13652", "pmid": "37183186", "labels": {"Category: Post-COVID": null, "Type: Review": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:09:48.818Z", "modified": "2023-10-04T06:10:33.707Z"}, {"entity": "publication", "iuid": "721ff2ee08c24dc48b1f10b421760f89", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/721ff2ee08c24dc48b1f10b421760f89.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/721ff2ee08c24dc48b1f10b421760f89"}}, "title": "It turned into something else: patients' long-term experiences of transitions to or from telepsychotherapy during the COVID-19 pandemic.", "authors": [{"family": "von Below", "given": "Camilla", "initials": "C"}, {"family": "Bergsten", "given": "Jenny", "initials": "J"}, {"family": "Midbris", "given": "Ther\u00e9se", "initials": "T"}, {"family": "Philips", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Werbart", "given": "Andrzej", "initials": "A"}], "type": "journal article", "published": "2023-05-12", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "14", "issue": null, "pages": "1142233"}, "abstract": "The shift from in-person therapy to telepsychotherapy during the COVID-19 pandemic was unprepared for, sudden, and inevitable. This study explored patients' long-term experiences of transitions to telepsychotherapy and back to the office.\r\n\r\nData were collected approximately two years after the declaration of COVID-19 as a pandemic. Eleven patients were interviewed (nine women and two men, aged 28 to 56, six in psychodynamic psychotherapy, five in CBT). Treatments switched between in-person and video/telephone sessions. Interview transcripts were analyzed applying the qualitative methodology of inductive thematic analysis.\r\n\r\n(1) The patients experienced the process in telepsychotherapy as impeded. Interventions were difficult to understand and lost impact. Routines surrounding the therapy sessions were lost. Conversations were less serious and lost direction. (2) Understanding was made more difficult when the nuances of non-verbal communication were lost. (3) The emotional relationship was altered. Remote therapy was perceived as something different from regular therapy, and once back in the therapy room, the patients felt that therapy started anew. The emotional presence was experienced as weakened, but some of the patients found expressing their feelings easier in the absence of bodily co-presence. According to the patients, in-person presence contributed to their security and trust, whereas they felt that the therapists were different when working remotely, behaving in a more easygoing and familiar way, as well as more solution-focused, supportive and unprofessional, less understanding and less therapeutic. Despite this, (4) telepsychotherapy also gave the patients an opportunity to take therapy with them into their everyday lives.\r\n\r\nThe results suggest that in the long run, remote psychotherapy was seen as a good enough alternative when needed. The present study indicates that format alternations have an impact on which interventions can be implemented, which can have important implications for psychotherapy training and supervision in an era when telepsychotherapy is becoming increasingly common.", "doi": "10.3389/fpsyg.2023.1142233", "pmid": "37251023", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10213395"}], "notes": [], "created": "2023-10-04T05:11:38.740Z", "modified": "2023-10-04T07:17:13.780Z"}, {"entity": "publication", "iuid": "80b404bff0f7468b8e2191f370d09e8f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/80b404bff0f7468b8e2191f370d09e8f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/80b404bff0f7468b8e2191f370d09e8f"}}, "title": "A novel precision-serology assay for SARS-CoV-2 infection based on linear B-cell epitopes of Spike protein.", "authors": [{"family": "Lundin", "given": "Samuel B", "initials": "SB"}, {"family": "Kann", "given": "Hanna", "initials": "H"}, {"family": "Fulurija", "given": "Alma", "initials": "A"}, {"family": "Andersson", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Nakka", "given": "Sravya S", "initials": "SS"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "L"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Harandi", "given": "Ali M", "initials": "AM"}], "type": "journal article", "published": "2023-05-12", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "1166924"}, "abstract": "The COVID-19 pandemic illustrates the need for serology diagnostics with improved accuracy. While conventional serology based on recognition of entire proteins or subunits thereof has made significant contribution to the antibody assessment space, it often suffers from sub-optimal specificity. Epitope-based, high-precision, serology assays hold potential to capture the high specificity and diversity of the immune system, hence circumventing the cross-reactivity with closely related microbial antigens.\r\n\r\nWe herein report mapping of linear IgG and IgA antibody epitopes of the SARS-CoV-2 Spike (S) protein in samples from SARS-CoV-2 exposed individuals along with certified SARS-CoV-2 verification plasma samples using peptide arrays.\r\n\r\nWe identified 21 distinct linear epitopes. Importantly, we showed that pre-pandemic serum samples contain IgG antibodies reacting to the majority of protein S epitopes, most likely as a result of prior infection with seasonal coronaviruses. Only 4 of the identified SARS-CoV-2 protein S linear epitopes were specific for SARS-CoV-2 infection. These epitopes are located at positions 278-298 and 550-586, just proximal and distal to the RBD, as well as at position 1134-1156 in the HR2 subdomain and at 1248-1271 in the C-terminal subdomain of protein S. To substantiate the applicability of our findings, we tested three of the high-accuracy protein S epitopes in a Luminex assay, using a certified validation plasma sample set from SARS-CoV-2 infected individuals. The Luminex results were well aligned with the peptide array results, and correlated very well with in-house and commercial immune assays for RBD, S1 and S1/S2 domains of protein S.\r\n\r\nWe present a comprehensive mapping of linear B-cell epitopes of SARS-CoV-2 protein S, that identifies peptides suitable for a precision serology assay devoid of cross-reactivity. These results have implications for development of highly specific serology test for exposure to SARS-CoV-2 and other members of the coronaviridae family, as well as for rapid development of serology tests for future emerging pandemic threats.", "doi": "10.3389/fimmu.2023.1166924", "pmid": "37251407", "labels": {"Category: Proteins": null, "Funder: VR": null, "Funder: Vinnova": null, "Category: Serology": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC10213285"}], "notes": [], "created": "2023-10-04T05:08:59.564Z", "modified": "2023-10-04T05:52:28.750Z"}, {"entity": "publication", "iuid": "c5dbc692903546b79ffa2df414f5fcbf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5dbc692903546b79ffa2df414f5fcbf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5dbc692903546b79ffa2df414f5fcbf"}}, "title": "Validation of myocarditis diagnoses in the Swedish patient register for analyses of potential adverse reactions to COVID-19 vaccines.", "authors": [{"family": "Gedeborg", "given": "Rolf", "initials": "R"}, {"family": "Holm", "given": "Lennart", "initials": "L"}, {"family": "Feltelius", "given": "Nils", "initials": "N"}, {"family": "Sundstr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Eggers", "given": "Kai M", "initials": "KM"}, {"family": "Nurminen", "given": "Marja-Leena", "initials": "M"}, {"family": "Gr\u00fcnewald", "given": "Maria", "initials": "M"}, {"family": "Pihlstr\u00f6m", "given": "Nicklas", "initials": "N"}, {"family": "Zethelius", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Ljung", "given": "Rickard", "initials": "R"}], "type": "journal article", "published": "2023-05-11", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "issn-l": "0300-9734", "volume": "128", "issue": null, "pages": null}, "abstract": "Coronavirus disease 2019 (COVID-19) mRNA vaccines are associated with an increased risk of myocarditis using hospital discharge diagnoses as an outcome. The validity of these register-based diagnoses is uncertain.\r\n\r\nPatient records for subjects < 40 years of age and a diagnosis of myocarditis in the Swedish National Patient Register were manually reviewed. Brighton Collaboration diagnosis criteria for myocarditis were applied based on patient history, clinical examination, laboratory data, electrocardiograms, echocardiography, magnetic resonance imaging and myocardial biopsy. Poisson regression was used to estimate incidence rate ratios, comparing the register-based outcome variable to validated outcomes. Interrater reliability was assessed by a blinded re-evaluation.\r\n\r\nOverall, 95.6% (327/342) of cases registered as myocarditis were confirmed (definite, probable or possible myocarditis according to Brighton Collaboration diagnosis criteria, positive predictive value 0.96 [95% CI 0.93-0.98]). Of the 4.4% (15/342) cases reclassified as no myocarditis or as insufficient information, two cases had been exposed to the COVID-19 vaccine no more than 28 days before the myocarditis diagnosis, two cases were exposed >28 days before admission and 11 cases were unexposed to the vaccine. The reclassification had only minor impact on incidence rate ratios for myocarditis following COVID-19 vaccination. In total, 51 cases were sampled for a blinded re-evaluation. Of the 30 randomly sampled cases initially classified as either definite or probably myocarditis, none were re-classified after re-evaluation. Of the in all 15 cases initially classified as no myocarditis or insufficient information, 7 were after re-evaluation re-classified as probable or possible myocarditis. This re-classification was mostly due to substantial variability in electrocardiogram interpretation.\r\n\r\nThis validation of register-based diagnoses of myocarditis by manual patient record review confirmed the register diagnosis in 96% of cases and had high interrater reliability. Reclassification had only a minor impact on the incidence rate ratios for myocarditis following COVID-19 vaccination.", "doi": "10.48101/ujms.v128.9290", "pmid": "37223633", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10202079"}, {"db": "pii", "key": "9290"}], "notes": [], "created": "2023-10-04T05:10:23.710Z", "modified": "2023-10-04T06:36:38.159Z"}, {"entity": "publication", "iuid": "d2755f6aac6b4f11beef7264eb00f65d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d2755f6aac6b4f11beef7264eb00f65d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d2755f6aac6b4f11beef7264eb00f65d"}}, "title": "Social and moral psychology of COVID-19 across 69 countries.", "authors": [{"family": "Azevedo", "given": "Flavio", "initials": "F", "orcid": "0000-0001-9000-8513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7864cb0e9bf846d6b69a6a5bf65cbd91.json"}}, {"family": "Pavlovi\u0107", "given": "Tomislav", "initials": "T"}, {"family": "R\u00eago", "given": "Gabriel G", "initials": "GG"}, {"family": "Ay", "given": "F Ceren", "initials": "FC"}, {"family": "Gjoneska", "given": "Biljana", "initials": "B", "orcid": "0000-0003-1200-6672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37b6c574b4824a4eae77730b96814547.json"}}, {"family": "Etienne", "given": "Tom W", "initials": "TW"}, {"family": "Ross", "given": "Robert M", "initials": "RM", "orcid": "0000-0001-8711-1675", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49cb2e4d713844729ee7d64213f3cdbe.json"}}, {"family": "Sch\u00f6negger", "given": "Philipp", "initials": "P"}, {"family": "Ria\u00f1o-Moreno", "given": "Juli\u00e1n C", "initials": "JC"}, {"family": "Cichocka", "given": "Aleksandra", "initials": "A", "orcid": "0000-0003-1703-1586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0cc1202c8fb34d07952c7d99ab43bf87.json"}}, {"family": "Capraro", "given": "Valerio", "initials": "V"}, {"family": "Cian", "given": "Luca", "initials": "L"}, {"family": "Longoni", "given": "Chiara", "initials": "C"}, {"family": "Chan", "given": "Ho Fai", "initials": "HF", "orcid": "0000-0002-7281-5212", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f60a9007efb4abf8a952c375ea1abdf.json"}}, {"family": "Van Bavel", "given": "Jay J", "initials": "JJ", "orcid": "0000-0002-2520-0442", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/344fbd5da7bc4259b3f70839f401c84c.json"}}, {"family": "Sj\u00e5stad", "given": "Hallgeir", "initials": "H"}, {"family": "Nezlek", "given": "John B", "initials": "JB"}, {"family": "Alfano", "given": "Mark", "initials": "M"}, {"family": "Gelfand", "given": "Michele J", "initials": "MJ"}, {"family": "Birtel", "given": "Mich\u00e8le D", "initials": "MD"}, {"family": "Cislak", "given": "Aleksandra", "initials": "A"}, {"family": "Lockwood", "given": "Patricia L", "initials": "PL", "orcid": "0000-0001-7195-9559", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d77d4779b0ff456b906f2001dc3aa36f.json"}}, {"family": "Abts", "given": "Koen", "initials": "K"}, {"family": "Agadullina", "given": "Elena", "initials": "E"}, {"family": "Aruta", "given": "John Jamir Benzon", "initials": "JJB"}, {"family": "Besharati", "given": "Sahba Nomvula", "initials": "SN"}, {"family": "Bor", "given": "Alexander", "initials": "A", "orcid": "0000-0002-2624-9221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/048bdb252beb4b2599b619f41ace6277.json"}}, {"family": "Choma", "given": "Becky L", "initials": "BL"}, {"family": "Crabtree", "given": "Charles David", "initials": "CD", "orcid": "0000-0001-5144-8671", "researcher": {"href": 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"0000-0003-1431-568X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12d5285132e14b7bbca2607a084fb449.json"}}, {"family": "Yilmaz", "given": "Onurcan", "initials": "O"}, {"family": "Yogeeswaran", "given": "Kumar", "initials": "K", "orcid": "0000-0002-1978-5077", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ef06acca6df4009bd0ab178af33551b.json"}}, {"family": "Ziemer", "given": "Carolin-Theresa", "initials": "C"}, {"family": "Zwaan", "given": "Rolf A", "initials": "RA"}, {"family": "Boggio", "given": "Paulo S", "initials": "PS"}, {"family": "Sampaio", "given": "Waldir M", "initials": "WM", "orcid": "0000-0002-6066-4314", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/003b9727584c4c2bb054a6ed2448c809.json"}}], "type": "dataset", "published": "2023-05-11", "journal": {"title": "Sci Data", "issn": "2052-4463", "issn-l": null, "volume": "10", "issue": "1", "pages": "272"}, "abstract": "The COVID-19 pandemic has affected all domains of human life, including the economic and social fabric of societies. One of the central strategies for managing public health throughout the pandemic has been through persuasive messaging and collective behaviour change. To help scholars better understand the social and moral psychology behind public health behaviour, we present a dataset comprising of 51,404 individuals from 69 countries. This dataset was collected for the International Collaboration on Social & Moral Psychology of COVID-19 project (ICSMP COVID-19). This social science survey invited participants around the world to complete a series of moral and psychological measures and public health attitudes about COVID-19 during an early phase of the COVID-19 pandemic (between April and June 2020). The survey included seven broad categories of questions: COVID-19 beliefs and compliance behaviours; identity and social attitudes; ideology; health and well-being; moral beliefs and motivation; personality traits; and demographic variables. We report both raw and cleaned data, along with all survey materials, data visualisations, and psychometric evaluations of key variables.", "doi": "10.1038/s41597-023-02080-8", "pmid": "37169799", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10173241"}, {"db": "pii", "key": "10.1038/s41597-023-02080-8"}], "notes": [], "created": "2023-10-04T05:10:30.964Z", "modified": "2023-10-04T06:44:19.514Z"}, {"entity": "publication", "iuid": "fc726a79a3c0468087e48d2b34902664", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc726a79a3c0468087e48d2b34902664.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc726a79a3c0468087e48d2b34902664"}}, "title": "Current tobacco use and SARS-CoV-2 infection in two Norwegian population-based cohorts.", "authors": [{"family": "Caspersen", "given": "Ida Henriette", "initials": "IH"}, {"family": "Trogstad", "given": "Lill", "initials": "L"}, {"family": "Galanti", "given": "Maria Rosaria", "initials": "MR"}, {"family": "Karvonen", "given": "Sakari", "initials": "S"}, {"family": "Pe\u00f1a", "given": "Sebasti\u00e1n", "initials": "S"}, {"family": "Shaaban", "given": "Ahmed Nabil", "initials": "AN"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}, {"family": "Magnus", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2023-05-10", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "23", "issue": "1", "pages": "846"}, "abstract": "Clear evidence of an increased risk for SARS-CoV-2 infection among smokers has not been established. We aimed to investigate associations between cigarette smoking or use of snus (snuff) and other nicotine-containing products and a positive SARS-CoV-2 test, taking test behavior into account.\r\n\r\nCurrent tobacco use and testing behavior during the pandemic were recorded by adult participants from the Norwegian Mother, Father and Child Cohort Study and The Norwegian Influenza Pregnancy Cohort. SARS-CoV-2 infection status was obtained from The Norwegian Surveillance System for Communicable Diseases (MSIS) in May 2021 (n = 78,860) and antibody measurements (n = 5581). We used logistic regression models stratified by gender and adjusted for age, education, region, number of household members, and work situation.\r\n\r\nSnus use was more common among men (26%) than women (9%) and more prevalent than cigarette smoking. We found no clear associations between cigarette smoking or snus and a COVID-19 diagnosis among men. Associations among women were conflicting, indicating that cigarette smoke was negatively associated with a diagnosis (OR 0.51, 95% CI 0.35, 0.75), while no association was found for snus use (OR 1.07, 95% CI 0.86, 1.34). Compared with non-users of tobacco, both cigarette smokers and snus users had increased odds of being tested for SARS-CoV-2.\r\n\r\nCigarette smoking, but not snus use, was negatively associated with SARS-CoV-2 infection in women. The lack of an association between snus use and SARS-CoV-2 infection in this population with prevalent snus use does not support the hypothesis of a protective effect of nicotine.", "doi": "10.1186/s12889-023-15822-5", "pmid": "37165385", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10170041"}, {"db": "pii", "key": "10.1186/s12889-023-15822-5"}], "notes": [], "created": "2023-10-04T05:08:57.146Z", "modified": "2023-10-04T05:50:44.009Z"}, {"entity": "publication", "iuid": "34b32b64758d4e9eb5e573fc545c5bbf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/34b32b64758d4e9eb5e573fc545c5bbf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/34b32b64758d4e9eb5e573fc545c5bbf"}}, "title": "Articulations of 'Funeral' in Swedish Newspapers During the Covid-19 Pandemic.", "authors": [{"family": "Jarnkvist", "given": "Karin", "initials": "K", "orcid": "0000-0002-6408-2952", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3418f7feda5247efae3f9bb8c785a6e3.json"}}], "type": "journal article", "published": "2023-05-10", "journal": {"title": "Omega (Westport)", "issn": "1541-3764", "issn-l": null, "volume": null, "issue": null, "pages": "302228231174601"}, "abstract": "This article explores how 'funeral' was articulated in Swedish newspapers during the Covid-19 pandemic and how such articulations relate to power and ideology. Articles from the six most prominent Swedish newspapers, published over 2 years, have been analyzed using critical discourse analysis and intersectionality. The study reveals three funeral discourses dominating during different periods of the pandemic: 'Funeral as a risk,' 'Funeral as an essential ritual,' and 'Funeral as a profession.' Altogether, the three discourses expose an ideal of 'the responsible mourner.' This rational woman follows the funeral restrictions and arranges a church funeral shortly after the death of a relative. The 'good funeral' is portrayed as a church funeral with physically present mourners, performed according to the deceased's will and in honor of the dead. The 'bad funeral,' described as the opposite of the 'good funeral,' dominates the understanding of the pandemic funeral situation.", "doi": "10.1177/00302228231174601", "pmid": "37165654", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:11:36.308Z", "modified": "2023-10-04T07:15:59.305Z"}, {"entity": "publication", "iuid": "1fc932cb2ce44153aa4bb828ae2ebc7d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1fc932cb2ce44153aa4bb828ae2ebc7d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1fc932cb2ce44153aa4bb828ae2ebc7d"}}, "title": "Mucosal immunization with lactiplantibacillus plantarum-displaying recombinant SARS-CoV-2 epitopes on the surface induces humoral and mucosal immune responses in mice.", "authors": [{"family": "Hwang", "given": "In-Chan", "initials": "I"}, {"family": "Valeriano", "given": "Valerie Diane", "initials": "VD"}, {"family": "Song", "given": "Ji Hoon", "initials": "JH"}, {"family": "Pereira", "given": "Marcela", "initials": "M"}, {"family": "Oh", "given": "Ju Kyoung", "initials": "JK"}, {"family": "Han", "given": "Kyudong", "initials": "K"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Kang", "given": "Dae-Kyung", "initials": "D"}], "type": "journal article", "published": "2023-05-09", "journal": {"title": "Microb Cell Fact", "issn": "1475-2859", "issn-l": null, "volume": "22", "issue": "1", "pages": "96"}, "abstract": "The use of probiotic lactic acid bacteria as a mucosal vaccine vector is considered a promising alternative compared to the use of other microorganisms because of its \"Generally Regarded as Safe\" status, its potential adjuvant properties, and its tolerogenicity to the host. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease (COVID-19), is highly transmissible and pathogenic. This study aimed to determine the potential of Lactiplantibacillus plantarum expressing SARS-CoV-2 epitopes as a mucosal vaccine against SARS-CoV-2.\r\n\r\nIn this study, the possible antigenic determinants of the spike (S1-1, S1-2, S1-3, and S1-4), membrane (ME1 and ME2), and envelope (E) proteins of SARS-CoV-2 were predicted, and recombinant L. plantarum strains surface-displaying these epitopes were constructed. Subsequently, the immune responses induced by these recombinant strains were compared in vitro and in vivo. Most surface-displayed epitopes induced pro-inflammatory cytokines [tumor necrosis factor alpha (TNF-\u03b1 and interleukin (IL)-6] and anti-inflammatory cytokines (IL-10) in lipopolysaccharide-induced RAW 264.7, with the highest anti-inflammatory to pro-inflammatory cytokine ratio in the S1-1 and S1-2 groups, followed by that in the S1-3 group. When orally administered of recombinant L. plantarum expressing SARS-CoV-2 epitopes in mice, all epitopes most increased the expression of IL-4, along with induced levels of TNF-\u03b1, interferon-gamma, and IL-10, specifically in spike protein groups. Thus, the surface expression of epitopes from the spike S1 protein in L. plantarum showed potential immunoregulatory effects, suggesting its ability to potentially circumvent hyperinflammatory states relevant to monocyte/macrophage cell activation. At 35 days post immunization (dpi), serum IgG levels showed a marked increase in the S1-1, S1-2, and S1-3 groups. Fecal IgA levels increased significantly from 21 dpi in all the antigen groups, but the boosting effect after 35 dpi was explicitly observed in the S1-1, S1-2, and S1-3 groups. Thus, the oral administration of SARS-CoV-2 antigens into mice induced significant humoral and mucosal immune responses.\r\n\r\nThis study suggests that L. plantarum is a potential vector that can effectively deliver SARS-CoV-2 epitopes to intestinal mucosal sites and could serve as a novel approach for SARS-CoV-2 mucosal vaccine development.", "doi": "10.1186/s12934-023-02100-7", "pmid": "37161468", "labels": {"Funder: VR": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10169176"}, {"db": "pii", "key": "10.1186/s12934-023-02100-7"}], "notes": [], "created": "2023-10-04T05:09:02.049Z", "modified": "2023-10-04T05:54:36.250Z"}, {"entity": "publication", "iuid": "5dd3c0e88dc24abe95c6c5328fec4d23", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5dd3c0e88dc24abe95c6c5328fec4d23.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5dd3c0e88dc24abe95c6c5328fec4d23"}}, "title": "Vaccine effectiveness of BNT162b2 mRNA Covid-19 Vaccine in Children below 5 Years in German Primary Care", "authors": [{"family": "Strumann", "given": "Christoph", "initials": "C", "orcid": "0000-0003-2725-6543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ea86e19543e4c0bb8ff7820e029fb1e.json"}}, {"family": "Ranzani", "given": "Otavio", "initials": "O", "orcid": "0000-0002-4677-6862", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/891f1de2767b44efbca8b6e7f5e18874.json"}}, {"family": "Moor", "given": "Jeanne", "initials": "J"}, {"family": "Berner", "given": "Reinhard", "initials": "R", "orcid": "0000-0002-6216-9173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2afcdc91e9424d9285eeb1526874c18b.json"}}, {"family": "T\u00f6pfner", "given": "Nicole", "initials": "N", "orcid": "0000-0002-9693-4419", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8c908b0701b4c6b9fb6e26acb479b8f.json"}}, {"family": "Chao", "given": "Cho Ming", "initials": "CM", "orcid": "0000-0002-0034-8264", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e1c91c06f144eb5bfca0a7126b69e11.json"}}, {"family": "Moor", "given": "Matthias B", "initials": "MB", "orcid": "0000-0002-7717-651X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01cf6b66149b43339c7a79fde358b702.json"}}], "type": "posted-content", "published": "2023-05-08", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.05.05.23289209", "pmid": null, "labels": {"Type: Preprint": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:11:59.151Z", "modified": "2023-10-04T07:25:20.770Z"}, {"entity": "publication", "iuid": "cfbc4759b84b4935802122112005ce87", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfbc4759b84b4935802122112005ce87.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfbc4759b84b4935802122112005ce87"}}, "title": "Vaccine-induced correlate of protection against fatal COVID-19 in older and frail adults during waves of neutralization-resistant variants of concern: an observational study.", "authors": [{"family": "Vikstr\u00f6m", "given": "Linnea", "initials": "L"}, {"family": "Fj\u00e4llstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Gwon", "given": "Yong-Dae", "initials": "Y"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Wigren-Bystr\u00f6m", "given": "Julia", "initials": "J"}, {"family": "Evander", "given": "Magnus", "initials": "M"}, {"family": "Bladh", "given": "Oscar", "initials": "O"}, {"family": "Widerstr\u00f6m", "given": "Micael", "initials": "M"}, {"family": "Molnar", "given": "Christian", "initials": "C"}, {"family": "Rasmussen", "given": "Gunl\u00f6g", "initials": "G"}, {"family": "Bennet", "given": "Louise", "initials": "L"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}, {"family": "Tevell", "given": "Staffan", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}], "type": "journal article", "published": "2023-05-06", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "issn-l": null, "volume": "30", "issue": null, "pages": "100646"}, "abstract": "To inform future preventive measures including repeated vaccinations, we have searched for a clinically useful immune correlate of protection against fatal COVID-19 among nursing homes residents.\r\n\r\nWe performed repeated capillary blood sampling with analysis of S-binding IgG in an open cohort of nursing home residents in Sweden. We analyzed immunological and registry data from 16 September 2021 to 31 August 2022 with follow-up of deaths to 30 September 2022. The study period included implementation of the 3rd and 4th mRNA monovalent vaccine doses and Omicron virus waves.\r\n\r\nA total of 3012 nursing home residents with median age 86 were enrolled. The 3rd mRNA dose elicited a 99-fold relative increase of S-binding IgG in blood and corresponding increase of neutralizing antibodies. The 4th mRNA vaccine dose boosted levels 3.8-fold. Half-life of S-binding IgG was 72 days. A total 528 residents acquired their first SARS-CoV-2 infection after the 3rd or the 4th vaccine dose and the associated 30-day mortality was 9.1%. We found no indication that levels of vaccine-induced antibodies protected against infection with Omicron VOCs. In contrast, the risk of death was inversely correlated to levels of S-directed IgG below the 20th percentile. The death risk plateaued at population average above the lower 35th percentile of S-binding IgG.\r\n\r\nIn the absence of neutralizing antibodies that protect from infection, quantification of S-binding IgG post vaccination may be useful to identify the most vulnerable for fatal COVID-19 among the oldest and frailest. This information is of importance for future strategies to protect vulnerable populations against neutralization resistant variants of concern.\r\n\r\nSwedish Research Council, SciLifeLab via Knut and Alice Wallenberg Foundation, VINNOVA. Swedish Healthcare Regions, and Erling Persson Foundation.", "doi": "10.1016/j.lanepe.2023.100646", "pmid": "37363799", "labels": {"Funder: VR": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10163377"}, {"db": "pii", "key": "S2666-7762(23)00065-0"}], "notes": [], "created": "2023-07-13T11:35:27.330Z", "modified": "2023-10-04T10:01:29.263Z"}, {"entity": "publication", "iuid": "8ad583f7951244339eefca386b4d8b31", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ad583f7951244339eefca386b4d8b31.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ad583f7951244339eefca386b4d8b31"}}, "title": "Knowledge and attitudes toward COVID-19 vaccination in Sudan: A cross-sectional study.", "authors": [{"family": "Badi", "given": "Safaa", "initials": "S"}, {"family": "Babiker", "given": "Loai Abdelgadir", "initials": "LA"}, {"family": "Aldow", "given": "Abdullah Yasseen", "initials": "AY"}, {"family": "Abas", "given": "Almigdad Badr Aldeen", "initials": "ABA"}, {"family": "Eisa", "given": "Mazen Abdelhafiez", "initials": "MA"}, {"family": "Abu-Ali", "given": "Mohamed Nour", "initials": "MN"}, {"family": "Abdella", "given": "Wagass Abdelrhman", "initials": "WA"}, {"family": "Marzouq", "given": "Mohamed Elsir", "initials": "ME"}, {"family": "Ahmed", "given": "Musaab", "initials": "M"}, {"family": "Omer", "given": "Abubakr Ali M", "initials": "AAM"}, {"family": "Ahmed", "given": "Mohamed H", "initials": "MH"}], "type": "journal article", "published": "2023-05-06", "journal": {"title": "AIMS Public Health", "issn": "2327-8994", "issn-l": null, "volume": "10", "issue": "2", "pages": "310-323"}, "abstract": "Vaccines are an essential part of public health interventions to mitigate the devastating health and non-health impacts of COVID-19 pandemic. Despite the fact that Sudan launched the COVID-19 vaccination program in March 2021, only 10% of the population received their two primary doses of vaccines by the end of May 2022. This delayed uptake of vaccines obviously warrants investigation. Therefore, we have conducted this study to evaluate the knowledge, attitude and acceptance of the general population in Sudan toward COVID-19 vaccines.\r\n\r\nA descriptive cross-sectional community-based study. The data were collected using an electronic questionnaire from 403 individuals living in Khartoum, Sudan. The data were processed using the Statistical Package for Social Sciences (SPSS), and data analysis was performed using appropriate tests.\r\n\r\n51% of the participants were found to have sufficient knowledge about the COVID-19 vaccine, and the knowledge level is higher among those educated beyond the secondary school and those who were employed. Among those unvaccinated, only 47% of the participants expressed their intention to take the vaccine when offered to them. The major reason for not trusting the vaccine is safety concerns expressed by 65.5% of the unvaccinated.\r\n\r\nHigher education levels and employment were associated with an increase in sufficient knowledge about the vaccine in around half of the participants. However, most of participants had not taken the vaccine at the time of the study, and the trust in vaccines is not high. Effective interventions by the health authorities are needed to address these issues in order to accelerate the COVID-19 vaccination program in Sudan.", "doi": "10.3934/publichealth.2023023", "pmid": "37304594", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10251048"}, {"db": "pii", "key": "publichealth-10-02-023"}], "notes": [], "created": "2023-10-04T09:31:41.409Z", "modified": "2023-10-04T10:52:10.669Z"}, {"entity": "publication", "iuid": "9a57591bcba24b9093ebed26803aed22", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9a57591bcba24b9093ebed26803aed22.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9a57591bcba24b9093ebed26803aed22"}}, "title": "Companion restrictions in the emergency department during COVID-19: physician perceptions from the Western Cape, South Africa.", "authors": [{"family": "Wiebe", "given": "Lauren E", "initials": "LE", "orcid": "0000-0003-3363-9735", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6559dcbb0024449e97fb89574e910f41.json"}}, {"family": "Alvesson", "given": "Helle Molsted", "initials": "HM"}, {"family": "Stassen", "given": "Willem", "initials": "W", "orcid": "0000-0002-1486-4446", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c751063bf7cf45dc887049c9554e2555.json"}}], "type": "journal article", "published": "2023-05-05", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "5", "pages": "e070982"}, "abstract": "To determine emergency department (ED) physicians' perceptions regarding hospital companions being prohibited from accompanying the patient during COVID-19.\r\n\r\nTwo qualitative datasets were combined. Data collected included voice recordings, narrative interviewing and semistructured interviews. A reflexive thematic analysis was conducted and guided by the Normalisation Process Theory.\r\n\r\nSix hospital EDs in the Western Cape, South Africa.\r\n\r\nConvenience sampling was used to recruit a total of eight physicians working full time in the ED during COVID-19.\r\n\r\nThe lack of physical companions provided an opportunity for physicians to assess and reflect on a companion's role in efficient patient care. Physicians perceived that the COVID-19 restrictions illuminated that patient companions engaged in the ED as providers contributing to patient care by providing collateral information and patient support, while simultaneously engaging as consumers detracting physicians from their priorities and patient care. These restrictions prompted the physicians to consider how they understand their patients largely through the companions. When companions became virtual, the physicians were forced to shift how they perceive their patient, which included increased empathy.\r\n\r\nThe reflections of providers can feed into discussions about values within the healthcare system and can help explore the balance between medical and social safety, especially with companion restrictions still being practised in some hospitals. These perceptions illuminate various tradeoffs physicians had to consider throughout the pandemic and may be used to improve companion policies when planning for the continuation of the COVID-19 pandemic and future disease outbreaks.", "doi": "10.1136/bmjopen-2022-070982", "pmid": "37147101", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10163331"}, {"db": "pii", "key": "bmjopen-2022-070982"}], "notes": [], "created": "2023-10-04T05:10:34.020Z", "modified": "2023-10-04T06:45:49.656Z"}, {"entity": "publication", "iuid": "d9fdabb601214d838e8296641d250b76", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d9fdabb601214d838e8296641d250b76.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d9fdabb601214d838e8296641d250b76"}}, "title": "COVID vaccine evaluation of barriers and resources among families of children with diagnosed allergies.", "authors": [{"family": "Gooding", "given": "Gregory D", "initials": "GD"}, {"family": "Protudjer", "given": "Jennifer L", "initials": "JL"}, {"family": "Gabrielli", "given": "Sofianne", "initials": "S"}, {"family": "Mul\u00e9", "given": "Pasquale", "initials": "P"}, {"family": "Shand", "given": "Greg", "initials": "G"}, {"family": "Zhang", "given": "Xun", "initials": "X"}, {"family": "McCusker", "given": "Christine", "initials": "C"}, {"family": "Noya", "given": "Francisco J", "initials": "FJ"}, {"family": "Harvey", "given": "Maria", "initials": "M"}, {"family": "Chalifour", "given": "M\u00e9lodie", "initials": "M"}, {"family": "Sicard", "given": "Catherine", "initials": "C"}, {"family": "Abrams", "given": "Elissa", "initials": "E"}, {"family": "Amiel", "given": "Jacques-Alexandre", "initials": "J"}, {"family": "Ngo", "given": "Thanh-Thao", "initials": "T"}, {"family": "Bonnici", "given": "Andre", "initials": "A"}, {"family": "MacDonald", "given": "Noni", "initials": "N"}, {"family": "Ben-Shoshan", "given": "Moshe", "initials": "M"}], "type": "journal article", "published": "2023-05-05", "journal": {"title": "Front Allergy", "issn": "2673-6101", "issn-l": null, "volume": "4", "issue": null, "pages": "1101247"}, "abstract": "We aimed to determine vaccine hesitancy and the main barriers associated with the 2019 novel coronavirus, SARS-CoV-2 (COVID-19) vaccination among families of children diagnosed with food/drug/environmental allergies.\r\n\r\nBetween May and June 2021, we approached 146 families seen at the outpatient allergy clinic at the Montreal Children's Hospital and a community allergy practice were invited to complete an anonymous online survey on COVID-19 and vaccination attitudes and behaviour. Uni and multivariable logistic regressions were compared to estimate factors associated with vaccine hesitancy.\r\n\r\nAmong all patients, 24.1% reported vaccine hesitancy. The large majority of parents (95.2%) believed that vaccines work. The most common barrier to vaccination was fear of adverse side effects (57.0%). One-third of participants (31.5%) reported that a history of food, venom and drug allergy was a contraindication for COVID-19 vaccination. Fifty-nine (60.8%) participants stated that the dissemination of additional information would increase their willingness to be vaccinated. Most (96.9%) parents reported that their children's vaccinations were up to date. Hesitant families were more likely to be parents of children aged 6-10 years, be of Asian descent, report that mRNA vaccines are riskier than traditional vaccines, and report that the vaccine should not be given if the child has a history of allergic reaction to vaccines.\r\n\r\nVaccine hesitancy exists mainly among certain ethnic groups and families with young children. Allergies to food, venom and drug allergy are commonly perceived as contraindications for COVID-19 vaccination. Knowledge translation activities addressing parental concerns will help increase vaccination rates.", "doi": "10.3389/falgy.2023.1101247", "pmid": "37216150", "labels": {"Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10198258"}], "notes": [], "created": "2023-10-04T05:09:35.901Z", "modified": "2023-10-04T06:02:16.198Z"}, {"entity": "publication", "iuid": "27e3e8c68bd84f3c969c6cd81e935226", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27e3e8c68bd84f3c969c6cd81e935226.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27e3e8c68bd84f3c969c6cd81e935226"}}, "title": "Efficacy of the combination of monoclonal antibodies against the SARS-CoV-2 Beta and Delta variants.", "authors": [{"family": "Boonkrai", "given": "Chatikorn", "initials": "C"}, {"family": "Cotrone", "given": "Thomas S", "initials": "TS"}, {"family": "Chaisuriyong", "given": "Watchadaporn", "initials": "W"}, {"family": "Tantawichien", "given": "Terapong", "initials": "T"}, {"family": "Thisyakorn", "given": "Usa", "initials": "U"}, {"family": "Fernandez", "given": "Stefan", "initials": "S"}, {"family": "Hunsawong", "given": "Taweewun", "initials": "T"}, {"family": "Reed", "given": "Matthew", "initials": "M"}, {"family": "Wongtangprasert", "given": "Tossapon", "initials": "T"}, {"family": "Audomsun", "given": "Thittaya", "initials": "T"}, {"family": "Phakham", "given": "Tanapati", "initials": "T"}, {"family": "Attakitbancha", "given": "Chadaporn", "initials": "C"}, {"family": "Saelao", "given": "Pijitra", "initials": "P"}, {"family": "Focht", "given": "Dorota", "initials": "D"}, {"family": "Kimbung", "given": "Raymond", "initials": "R"}, {"family": "Welin", "given": "Martin", "initials": "M"}, {"family": "Malik", "given": "Aijaz Ahmad", "initials": "AA"}, {"family": "Pisitkun", "given": "Trairak", "initials": "T"}, {"family": "Srisawat", "given": "Nattachai", "initials": "N", "orcid": "0000-0002-8544-8132", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91b220be054242cd8f36efca9f2a70c8.json"}}], "type": "journal article", "published": "2023-05-04", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "5", "pages": "e0284173"}, "abstract": "The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently the biggest healthcare issue worldwide. This study aimed to develop a monoclonal antibody against SARS-CoV-2 from B cells of recovered COVID-19 patients, which might have beneficial therapeutic purposes for COVID-19 patients. We successfully generated human monoclonal antibodies (hmAbs) against the receptor binding domain (RBD) protein of SARS-CoV-2 using developed hybridoma technology. The isolated hmAbs against the RBD protein (wild-type) showed high binding activity and neutralized the interaction between the RBD and the cellular receptor angiotensin-converting enzyme 2 (ACE2) protein. Epitope binning and crystallography results displayed target epitopes of these antibodies in distinct regions beneficial in the mix as a cocktail. The 3D2 binds to conserved epitopes among multi-variants. Pseudovirion-based neutralization results revealed that the antibody cocktail, 1D1 and 3D2, showed high potency in multiple variants of SARS-CoV-2 infection. In vivo studies showed the ability of the antibody cocktail treatment (intraperitoneal (i.p.) administration) to reduce viral load (Beta variant) in blood and various tissues. While the antibody cocktail treatment (intranasal (i.n.) administration) could not significantly reduce the viral load in nasal turbinate and lung tissue, it could reduce the viral load in blood, kidney, and brain tissue. These findings revealed that the efficacy of the antibody cocktail, 1D1 and 3D2, should be further studied in animal models in terms of timing of administration, optimal dose, and efficacy to mitigate inflammation in targeted tissue such as nasal turbinate and lung.", "doi": "10.1371/journal.pone.0284173", "pmid": "37141227", "labels": {"Category: Serology": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10159178"}, {"db": "pii", "key": "PONE-D-22-27378"}], "notes": [], "created": "2023-10-04T05:08:54.527Z", "modified": "2023-10-04T05:32:42.672Z"}, {"entity": "publication", "iuid": "a1b5dafaa42c438e84a08bf58d2bf8fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a1b5dafaa42c438e84a08bf58d2bf8fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a1b5dafaa42c438e84a08bf58d2bf8fa"}}, "title": "Occupational risk of COVID-19 in foreign-born employees in Denmark.", "authors": [{"family": "Bonde", "given": "J P E", "initials": "JPE", "orcid": "0000-0002-8181-3673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e986911aef045ab8b4b289094387930.json"}}, {"family": "Begtrup", "given": "L M", "initials": "LM"}, {"family": "Jensen", "given": "J H", "initials": "JH"}, {"family": "Flachs", "given": "E M", "initials": "EM"}, {"family": "Jakobsson", "given": "K", "initials": "K"}, {"family": "Nielsen", "given": "C", "initials": "C"}, {"family": "Nilsson", "given": "K", "initials": "K"}, {"family": "Rylander", "given": "L", "initials": "L", "orcid": "0000-0001-8288-8207", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8599a02e51843e8b8f484bc30b6addb.json"}}, {"family": "Vilhelmsson", "given": "A", "initials": "A"}, {"family": "Petersen", "given": "K U", "initials": "KU"}, {"family": "T\u00f8ttenborg", "given": "S S", "initials": "SS", "orcid": "0000-0001-7742-4360", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1e0c5d0c8e249478ce31daacec1d318.json"}}], "type": "journal article", "published": "2023-05-03", "journal": {"title": "Occup Med (Lond)", "issn": "1471-8405", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Foreign-born workers in high-income countries experience higher rates of COVID-19 but the causes are only partially known.\r\n\r\nTo examine if the occupational risk of COVID-19 in foreign-born workers deviates from the risk in native-born employees in Denmark.\r\n\r\nWithin a registry-based cohort of all residents employed in Denmark (n = 2 451 542), we identified four-digit DISCO-08 occupations associated with an increased incidence of COVID-19-related hospital admission during 2020-21 (at-risk occupations). The sex-specific prevalence of at-risk employment in foreign born was compared with the prevalence in native born. Moreover, we examined if the country of birth modified the risk of a positive SARS-CoV-2 polymerase chain reaction (PCR) test and COVID-19-related hospital admission in at-risk occupations.\r\n\r\nWorkers born in low-income countries and male workers from Eastern Europe more often worked in at-risk occupations (relative risks between 1.16 [95% confidence interval {CI} 1.14-1.17] and 1.87 [95% CI 1.82-1.90]). Being foreign-born modified the adjusted risk of PCR test positivity (test for interaction P < 0.0001), primarily because of higher risk in at-risk occupations among men born in Eastern European countries (incidence rate ratio [IRR] 2.39 [95% CI 2.09-2.72] versus IRR 1.19 [95% CI 1.14-1.23] in native-born men). For COVID-19-related hospital admission, no overall interaction was seen, and in women, country of birth did not consistently modify the occupational risk.\r\n\r\nWorkplace viral transmission may contribute to an excess risk of COVID-19 in male workers born in Eastern Europe, but most foreign-born employees in at-risk occupations seem not to be at higher occupational risk than native born.", "doi": "10.1093/occmed/kqad044", "pmid": "37133767", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7150760"}], "notes": [], "created": "2023-10-04T05:08:48.484Z", "modified": "2023-10-04T05:23:13.528Z"}, {"entity": "publication", "iuid": "13eb9e68408349a6b1eade757bfb16f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13eb9e68408349a6b1eade757bfb16f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13eb9e68408349a6b1eade757bfb16f9"}}, "title": "Association between SARS-CoV-2 vaccination and healthcare contacts for menstrual disturbance and bleeding in women before and after menopause: nationwide, register based cohort study.", "authors": [{"family": "Ljung", "given": "Rickard", "initials": "R", "orcid": "0000-0002-0654-4530", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ba40c2b98b1442192811ba44ffbf967.json"}}, {"family": "Xu", "given": "YiYi", "initials": "Y", "orcid": "0000-0001-9106-0049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06663aac11174e88a79cbb8e2ec4f3c0.json"}}, {"family": "Sundstr\u00f6m", "given": "Anders", "initials": "A", "orcid": "0000-0003-2337-3371", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5acbd5b816884f06807b23bd3e2e6cad.json"}}, {"family": "Leach", "given": "Susannah", "initials": "S", "orcid": "0000-0002-9614-2753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18d00be831d241dca238b3253d1b45f6.json"}}, {"family": "Hallberg", "given": "Ebba", "initials": "E"}, {"family": "Bygdell", "given": "Maria", "initials": "M", "orcid": "0000-0002-0737-8642", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8384a1c06034aff9aae842750462643.json"}}, {"family": "Larsson", "given": "Maria", "initials": "M"}, {"family": "Arthurson", "given": "Veronica", "initials": "V"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}, {"family": "Gedeborg", "given": "Rolf", "initials": "R", "orcid": "0000-0002-8850-7863", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/234ef51ed7854efb8bbadc3ce35bf7d9.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}], "type": "journal article", "published": "2023-05-03", "journal": {"title": "BMJ", "issn": "1756-1833", "issn-l": null, "volume": "381", "issue": null, "pages": "e074778"}, "abstract": "To evaluate the risks of any menstrual disturbance and bleeding following SARS-CoV-2 vaccination in women who are premenopausal or postmenopausal.\r\n\r\nA nationwide, register based cohort study.\r\n\r\nAll inpatient and specialised outpatient care in Sweden from 27 December 2020 to 28 February 2022. A subset covering primary care for 40% of the Swedish female population was also included.\r\n\r\n2 946 448 Swedish women aged 12-74 years were included. Pregnant women, women living in nursing homes, and women with history of any menstruation or bleeding disorders, breast cancer, cancer of female genital organs, or who underwent a hysterectomy between 1 January 2015 and 26 December 2020 were excluded.\r\n\r\nSARS-CoV-2 vaccination, by vaccine product (BNT162b2, mRNA-1273, or ChAdOx1 nCoV-19 (AZD1222)) and dose (unvaccinated and first, second, and third dose) over two time windows (one to seven days, considered the control period, and 8-90 days).\r\n\r\nHealthcare contact (admission to hospital or visit) for menstrual disturbance or bleeding before or after menopause (diagnosed with the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision codes N91, N92, N93, N95).\r\n\r\n2 580 007 (87.6%) of 2 946 448 women received at least one SARS-CoV-2 vaccination and 1 652 472 (64.0%) 2 580 007 of vaccinated women received three doses before the end of follow-up. The highest risks for bleeding in women who were postmenopausal were observed after the third dose, in the one to seven days risk window (hazard ratio 1.28 (95% confidence interval 1.01 to 1.62)) and in the 8-90 days risk window (1.25 (1.04 to 1.50)). The impact of adjustment for covariates was modest. Risk of postmenopausal bleeding suggested a 23-33% increased risk after 8-90 days with BNT162b2 and mRNA-1273 after the third dose, but the association with ChAdOx1 nCoV-19 was less clear. For menstrual disturbance or bleeding in women who were premenopausal, adjustment for covariates almost completely removed the weak associations noted in the crude analyses.\r\n\r\nWeak and inconsistent associations were observed between SARS-CoV-2 vaccination and healthcare contacts for bleeding in women who are postmenopausal, and even less evidence was recorded of an association for menstrual disturbance or bleeding in women who were premenopausal. These findings do not provide substantial support for a causal association between SARS-CoV-2 vaccination and healthcare contacts related to menstrual or bleeding disorders.", "doi": "10.1136/bmj-2023-074778", "pmid": "37137493", "labels": {"Category: Health": null, "Funder: VR": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10543813"}], "notes": [], "created": "2023-10-04T05:11:41.147Z", "modified": "2023-10-04T07:18:52.921Z"}, {"entity": "publication", "iuid": "5133ce1ea10e46caae5b032df6ab2b09", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5133ce1ea10e46caae5b032df6ab2b09.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5133ce1ea10e46caae5b032df6ab2b09"}}, "title": "Sociodemographic Factors and Adjustment of Daily Activities During the COVID-19 Pandemic - Findings from the SHARE Corona Survey.", "authors": [{"family": "Olofsson", "given": "Jenny", "initials": "J", "orcid": "0000-0003-0725-951X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed1a80c621ef48b18f45766cc29ce54c.json"}}, {"family": "Fors Connolly", "given": "Filip", "initials": "F", "orcid": "0000-0002-3857-4398", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2fbe2c1c98804f25a5e6c6fdde21fe03.json"}}, {"family": "Malmberg", "given": "Gunnar", "initials": "G", "orcid": "0000-0003-0531-2743", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/efd0e5c960f04373a96ea862b4072b9d.json"}}, {"family": "Josefsson", "given": "Maria", "initials": "M", "orcid": "0000-0002-1812-3581", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b119b08d9787455894f5ee784f0805e5.json"}}, {"family": "Stattin", "given": "Mikael", "initials": "M", "orcid": "0000-0003-0817-0576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9679f7d8f5c8410d83103fcf7d88fe8e.json"}}], "type": "journal article", "published": "2023-05-01", "journal": {"title": "J Aging Soc Policy", "issn": "1545-0821", "issn-l": null, "volume": null, "issue": null, "pages": "1-23"}, "abstract": "In the wake of the COVID-19 pandemic in 2020, older people across Europe have adjusted their daily activities as personal risk avoidance and as an amendment to policy recommendations and restrictions. In this study, we use multilevel logistic regressions to examine to what extent sociodemographic factors are associated with activity reduction among the older population (50+) in Europe and whether these associations are moderated by governmental policy responses to COVID-19. By combining data for~35,000 respondents from the SHARE Corona Survey on reported changes in daily activities and stringency of restrictions at the national level, we find that older age, poorer health and being female versus male were (consistently) associated with greater activity reduction across all activities both in countries with weak and in those with strong restrictions. Associations between education, employment and living situation, on the one hand, and activity reduction, on the other, were weaker and less consistent. We conclude that differences between sociodemographic groups are rather similar for countries with weak and those with strong restrictions and hence argue that group-specific policy recommendation are relevant independent of stringency recommendations.", "doi": "10.1080/08959420.2023.2206077", "pmid": "37125862", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:10:47.974Z", "modified": "2023-10-04T06:58:45.924Z"}, {"entity": "publication", "iuid": "7fdb5107e7e6410682607672a304c086", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7fdb5107e7e6410682607672a304c086.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7fdb5107e7e6410682607672a304c086"}}, "title": "Transition from physical to online shopping alternatives due to the COVID-19 pandemic - A case study of Italy and Sweden.", "authors": [{"family": "Andruetto", "given": "Claudia", "initials": "C"}, {"family": "Bin", "given": "Elisa", "initials": "E"}, {"family": "Susilo", "given": "Yusak", "initials": "Y"}, {"family": "Pernest\u00e5l", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "Transp Res Part A Policy Pract", "issn": "0965-8564", "volume": "171", "pages": "103644", "issn-l": null}, "abstract": "Using 530 responses from an online questionnaire, this study aims to investigate the transition from physical to online shopping alternatives during the first wave of the COVID-19 pandemic at the individual level. The focus areas of the study are Sweden and Italy, two European countries that implemented contrasting prevention measures. This study analyses the impacts of the pandemic on the transition to online shopping activities, and identifies who among the respondents changed their shopping behaviour the most and how; and what the different shopping strategies are and who adopted them. Multivariate statistical analyses, including linear and binary logistic regressions and multinomial logit models, were used to analyse the dataset. In the analysis, the dataset was split between Italy and Sweden to take into account the contrasting prevention measures and the different social and economic backgrounds of the two countries; the results of this study confirm and highlight these differences. Moreover, the socio-demographic and household structures of the respondents were found to influence the amount and the direction of change in shopping behaviour during the first wave of the pandemic. The study also indicates some policies that can be implemented and/or further strengthened to increase the resilience of citizens in facing pandemics and to derive benefit from the behavioural changes that took place during the first wave of the pandemic.", "doi": "10.1016/j.tra.2023.103644", "pmid": "36960356", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10008802"}, {"db": "pii", "key": "S0965-8564(23)00064-2"}], "notes": [], "created": "2023-04-21T16:04:23.892Z", "modified": "2023-04-21T16:04:23.911Z"}, {"entity": "publication", "iuid": "6a85486d50604effabbb6b75db7a7082", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a85486d50604effabbb6b75db7a7082.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a85486d50604effabbb6b75db7a7082"}}, "title": "Segregation and the pandemic: The dynamics of daytime social diversity during COVID-19 in Greater Stockholm.", "authors": [{"family": "M\u00fc\u00fcrisepp", "given": "Kerli", "initials": "K"}, {"family": "J\u00e4rv", "given": "Olle", "initials": "O"}, {"family": "Sj\u00f6blom", "given": "Feliks", "initials": "F"}, {"family": "Toger", "given": "Marina", "initials": "M"}, {"family": "\u00d6sth", "given": "John", "initials": "J"}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "Appl Geogr", "issn": "0143-6228", "volume": "154", "pages": "102926", "issn-l": null}, "abstract": "In this study, we set out to understand how the changes in daily mobility of people during the first wave of the COVID-19 pandemic in spring 2020 influenced daytime spatial segregation. Rather than focusing on spatial separation, we approached this task from the perspective of daytime socio-spatial diversity - the degree to which people from socially different neighbourhoods share urban space during the day. By applying mobile phone data from Greater Stockholm, Sweden, the study examines weekly changes in 1) daytime social diversity across different types of neighbourhoods, and 2) population groups' exposure to diversity in their main daytime activity locations. Our findings show a decline in daytime diversity in neighbourhoods when the pandemic broke out in mid-March 2020. The decrease in diversity was marked in urban centres, and significantly different in neighbourhoods with different socio-economic and ethnic compositions. Moreover, the decrease in people's exposure to diversity in their daytime activity locations was even more profound and long-lasting. In particular, isolation from diversity increased more among residents of high-income majority neighbourhoods than of low-income minority neighbourhoods. We conclude that while some COVID-19-induced changes might have been temporary, the increased flexibility in where people work and live might ultimately reinforce both residential and daytime segregation.", "doi": "10.1016/j.apgeog.2023.102926", "pmid": "36999002", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC9998301"}, {"db": "pii", "key": "S0143-6228(23)00057-7"}], "notes": [], "created": "2023-04-21T15:50:37.167Z", "modified": "2023-04-21T15:50:59.427Z"}, {"entity": "publication", "iuid": "ca29acd5924d4774918cb18f04a947aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ca29acd5924d4774918cb18f04a947aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ca29acd5924d4774918cb18f04a947aa"}}, "title": "Pre- and post-vaccination characteristics and risk factors for COVID-19 outcomes in a Swedish population-based cohort of COPD patients.", "authors": [{"family": "Kirui", "given": "Brian K", "initials": "BK"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW", "orcid": "0000-0002-4387-4096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bb5d1f761ef48c4837ed4f984717f0e.json"}}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Franz\u00e9n", "given": "Stefan", "initials": "S", "orcid": "0000-0001-6622-3838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e2fc66fb68748eba5a7f8eb93c5ff3f.json"}}, {"family": "Stridsman", "given": "Caroline", "initials": "C", "orcid": "0000-0001-6622-3838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e2fc66fb68748eba5a7f8eb93c5ff3f.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "ERJ Open Res", "issn": "2312-0541", "issn-l": null, "volume": "9", "issue": "3", "pages": null}, "abstract": "Evidence on risk factors for Coronavirus disease 2019 (COVID-19) outcomes among patients with COPD in relation to COVID-19 vaccination remains limited. The objectives of the present study were to characterise determinants of COVID-19 infection, hospitalisation, intensive care unit (ICU) admission and death in COPD patients in their unvaccinated state compared to when vaccinated.\r\n\r\nWe included all COPD patients in the Swedish National Airway Register (SNAR). Events of COVID-19 infection (test and/or healthcare encounter), hospitalisation, ICU admission and death were identified from 1 January 2020 to 30 November 2021. Using adjusted Cox regression, associations between baseline sociodemographics, comorbidities, treatments, clinical measurements and COVID-19 outcomes, during unvaccinated and vaccinated follow-up time, were analysed.\r\n\r\nThe population-based COPD cohort included 87 472 patients, among whom 6771 (7.7%) COVID-19 infections, 2897 (3.3%) hospitalisations, 233 (0.3%) ICU admissions and 882 (1.0%) COVID-19 deaths occurred. During unvaccinated follow-up, risk of COVID-19 hospitalisation and death increased with age, male sex, lower education, non-married status and being foreign-born. Comorbidities increased risk of several outcomes, e.g. respiratory failure for infection and hospitalisation (adjusted hazard ratios (HR) 1.78, 95% CI 1.58-2.02 and 2.51, 2.16-2.91, respectively), obesity for ICU admission (3.52, 2.29-5.40) and cardiovascular disease for mortality (2.80, 2.16-3.64). Inhaled COPD therapy was associated with infection, hospitalisation and death. COPD severity was also associated with COVID-19, especially hospitalisation and death. Although the risk factor panorama was similar, COVID-19 vaccination attenuated HRs for some risk factors.\r\n\r\nThis study provides population-based evidence on predictive risk factors for COVID-19 outcomes and highlights the positive implications of COVID-19 vaccination for COPD patients.", "doi": "10.1183/23120541.00711-2022", "pmid": "37377661", "labels": {"Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10291311"}, {"db": "pii", "key": "00711-2022"}], "notes": [], "created": "2023-10-04T09:30:36.503Z", "modified": "2023-10-04T09:59:26.297Z"}, {"entity": "publication", "iuid": "757f413ea2304a4aac07ae5416a34990", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/757f413ea2304a4aac07ae5416a34990.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/757f413ea2304a4aac07ae5416a34990"}}, "title": "Microneedle Patch for Painless Intradermal Collection of Interstitial Fluid Enabling Multianalyte Measurement of Small Molecules, SARS-CoV-2 Antibodies, and Protein Profiling.", "authors": [{"family": "Ribet", "given": "Federico", "initials": "F", "orcid": "0000-0002-3549-0228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70e482c3c2454cb0924540e41bd5eb72.json"}}, {"family": "Bendes", "given": "Annika", "initials": "A"}, {"family": "Fredolini", "given": "Claudia", "initials": "C"}, {"family": "Dobielewski", "given": "Mikolaj", "initials": "M"}, {"family": "B\u00f6ttcher", "given": "Michael", "initials": "M"}, {"family": "Beck", "given": "Olof", "initials": "O"}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM"}, {"family": "Stemme", "given": "G\u00f6ran", "initials": "G"}, {"family": "Roxhed", "given": "Niclas", "initials": "N"}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "Adv Healthc Mater", "issn": "2192-2659", "issn-l": null, "volume": "12", "issue": "13", "pages": "e2202564"}, "abstract": "Blood sampling is a common practice to monitor health, but it entails a series of drawbacks for patients including pain and discomfort. Thus, there is a demand for more convenient ways to obtain samples. Modern analytical techniques enable monitoring of multiple bioanalytes in smaller samples, opening possibilities for new matrices, and microsampling technologies to be adopted. Interstitial fluid (ISF) is an attractive alternative matrix that shows good correlation with plasma concentration dynamics for several analytes and can be sampled in a minimally invasive and painless manner from the skin at the point-of-care. However, there is currently a lack of sampling devices compatible with clinical translation. Here, to tackle state-of-the-art limitations, a cost-effective and compact single-microneedle-based device designed to painlessly collect precisely 1.1 \u00b5L of dermal ISF within minutes is presented. The fluid is volume-metered, dried, and stably stored into analytical-grade paper within the microfluidic device. The obtained sample can be mailed to a laboratory, quantitatively analyzed, and provide molecular insights comparable to blood testing. In a human study, the possibility to monitor various classes of molecular analytes is demonstrated in ISF microsamples, including caffeine, hundreds of proteins, and SARS-CoV-2 antibodies, some being detected in ISF for the first time.", "doi": "10.1002/adhm.202202564", "pmid": "36748807", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Funder: H2020": null}, "xrefs": [{"db": "URL", "key": "https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fadhm.202202564&file=adhm202202564-sup-0001-SuppMat.pdf", "description": "https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fadhm.202202564&file=adhm202202564-sup-0001-SuppMat.pdf"}], "notes": [], "created": "2023-02-13T17:56:35.394Z", "modified": "2023-06-19T14:19:26.937Z"}, {"entity": "publication", "iuid": "97df576b98e6430cbe84455e52197b3a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/97df576b98e6430cbe84455e52197b3a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/97df576b98e6430cbe84455e52197b3a"}}, "title": "Insight into vaccination and meteorological factors on daily COVID-19 cases and mortality in Bangladesh.", "authors": [{"family": "Hasan", "given": "Mohammad Nayeem", "initials": "MN"}, {"family": "Islam", "given": "Md Aminul", "initials": "MA"}, {"family": "Sangkham", "given": "Sarawut", "initials": "S"}, {"family": "Werkneh", "given": "Adhena Ayaliew", "initials": "AA"}, {"family": "Hossen", "given": "Foysal", "initials": "F"}, {"family": "Haque", "given": "Md Atiqul", "initials": "MA"}, {"family": "Alam", "given": "Mohammad Morshad", "initials": "MM"}, {"family": "Rahman", "given": "Md Arifur", "initials": "MA"}, {"family": "Mukharjee", "given": "Sanjoy Kumar", "initials": "SK"}, {"family": "Chowdhury", "given": "Tahmid Anam", "initials": "TA"}, {"family": "Sosa-Hern\u00e1ndez", "given": "Juan Eduardo", "initials": "JE"}, {"family": "Jakariya", "given": "Md", "initials": "M"}, {"family": "Ahmed", "given": "Firoz", "initials": "F"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Sarkodie", "given": "Samuel Asumadu", "initials": "SA"}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "Groundw Sustain Dev", "issn": "2352-801X", "volume": "21", "pages": "100932", "issn-l": null}, "abstract": "The ongoing COVID-19 contagious disease caused by SARS-CoV-2 has disrupted global public health, businesses, and economies due to widespread infection, with 676.41 million confirmed cases and 6.77 million deaths in 231 countries as of February 07, 2023. To control the rapid spread of SARS-CoV-2, it is crucial to determine the potential determinants such as meteorological factors and their roles. This study examines how COVID-19 cases and deaths changed over time while assessing meteorological characteristics that could impact these disparities from the onset of the pandemic. We used data spanning two years across all eight administrative divisions, this is the first of its kind--showing a connection between meteorological conditions, vaccination, and COVID-19 incidences in Bangladesh. We further employed several techniques including Simple Exponential Smoothing (SES), Auto-Regressive Integrated Moving Average (ARIMA), Auto-Regressive Integrated Moving Average with explanatory variables (ARIMAX), and Automatic forecasting time-series model (Prophet). We further analyzed the effects of COVID-19 vaccination on daily cases and deaths. Data on COVID-19 cases collected include eight administrative divisions of Bangladesh spanning March 8, 2020, to January 31, 2023, from available online servers. The meteorological data include rainfall (mm), relative humidity (%), average temperature (\u00b0C), surface pressure (kPa), dew point (\u00b0C), and maximum wind speed (m/s). The observed wind speed and surface pressure show a significant negative impact on COVID-19 cases (-0.89, 95% confidence interval (CI): 1.62 to -0.21) and (-1.31, 95%CI: 2.32 to -0.29), respectively. Similarly, the observed wind speed and surface pressure show a significant negative impact on COVID-19 deaths (-0.87, 95% CI: 1.54 to -0.21) and (-3.11, 95%CI: 4.44 to -1.25), respectively. The impact of meteorological factors is almost similar when vaccination information is included in the model. However, the impact of vaccination in both cases and deaths model is significantly negative (for cases: 1.19, 95%CI: 2.35 to -0.38 and for deaths: 1.55, 95%CI: 2.88 to -0.43). Accordingly, vaccination effectively reduces the number of new COVID-19 cases and fatalities in Bangladesh. Thus, these results could assist future researchers and policymakers in the assessment of pandemics, by making thorough efforts that account for COVID-19 vaccinations and meteorological conditions.", "doi": "10.1016/j.gsd.2023.100932", "pmid": "36945723", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9977696"}, {"db": "pii", "key": "S2352-801X(23)00032-2"}], "notes": [], "created": "2023-04-21T16:07:26.169Z", "modified": "2023-04-21T16:07:26.184Z"}, {"entity": "publication", "iuid": "18e6b93c9ab24c4f91ca0341366a0aae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18e6b93c9ab24c4f91ca0341366a0aae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18e6b93c9ab24c4f91ca0341366a0aae"}}, "title": "Ambient air pollution exposure linked to long COVID among young adults: a nested survey in a population-based cohort in Sweden.", "authors": [{"family": "Yu", "given": "Zhebin", "initials": "Z"}, {"family": "Ekstr\u00f6m", "given": "Sandra", "initials": "S"}, {"family": "Bellander", "given": "Tom", "initials": "T"}, {"family": "Ljungman", "given": "Petter", "initials": "P"}, {"family": "Pershagen", "given": "G\u00f6ran", "initials": "G"}, {"family": "Eneroth", "given": "Kristina", "initials": "K"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "Bergstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Georgelis", "given": "Antonios", "initials": "A"}, {"family": "Stafoggia", "given": "Massimo", "initials": "M"}, {"family": "Gruzieva", "given": "Olena", "initials": "O"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "BAMSE COVID-19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "issn-l": null, "volume": "28", "issue": null, "pages": "100608"}, "abstract": "Post COVID-19 conditions, also known as long COVID, are of public health concern, but little is known about their underlying risk factors. We aimed to investigate associations of air pollution exposure with long COVID among Swedish young adults.\r\n\r\nWe used data from the BAMSE (Children, Allergy, Environment, Stockholm, Epidemiology [in Swedish]) cohort. From October 2021 to February 2022 participants answered a web-questionnaire focusing on persistent symptoms following acute SARS-CoV-2 infection. Long COVID was defined as symptoms after confirmed infection with SARS-CoV-2 lasting for two months or longer. Ambient air pollution levels (particulate matter \u22642.5 \u03bcm [PM2.5], \u226410 \u03bcm [PM10], black carbon [BC] and nitrogen oxides [NOx]) at individual-level addresses were estimated using dispersion modelling.\r\n\r\nA total of 753 participants with SARS-CoV-2 infection were included of whom 116 (15.4%) reported having long COVID. The most common symptoms were altered smell/taste (n = 80, 10.6%), dyspnea (n = 36, 4.8%) and fatigue (n = 34, 4.5%). Median annual PM2.5 exposure in 2019 (pre-pandemic) was 6.39 (interquartile range [IQR] 6.06-6.71) \u03bcg/m3. Adjusted Odds Ratios (95% confidence intervals) of PM2.5 per IQR increase were 1.28 (1.02-1.60) for long COVID, 1.65 (1.09-2.50) for dyspnea symptoms and 1.29 (0.97-1.70) for altered smell/taste. Positive associations were found for the other air pollutants and remained consistent across sensitivity analyses. Associations tended to be stronger among participants with asthma, and those having had COVID during 2020 (versus 2021).\r\n\r\nAmbient long-term PM2.5 exposure may affect the risk of long COVID in young adults, supporting efforts for continuously improving air quality.\r\n\r\nThe study received funding from the Swedish Research Council (grant no. 2020-01886, 2022-06340), the Swedish Research Council for Health, Working life and Welfare (FORTE grant no. 2017-01146), the Swedish Heart-Lung Foundation, Karolinska Institute (no. 2022-01807) and Region Stockholm (ALF project for cohort and database maintenance).", "doi": "10.1016/j.lanepe.2023.100608", "pmid": "37131862", "labels": {"Category: Post-COVID": null, "Funder: VR": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9989696"}, {"db": "pii", "key": "S2666-7762(23)00026-1"}], "notes": [], "created": "2023-10-04T05:10:14.692Z", "modified": "2023-10-04T06:31:11.088Z"}, {"entity": "publication", "iuid": "e2c251d61bc24c6ba1f59716f2af86f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2c251d61bc24c6ba1f59716f2af86f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2c251d61bc24c6ba1f59716f2af86f8"}}, "title": "Lessons learnt during COVID-19: making sense of Australian and Swedish university lecturers' experience.", "authors": [{"family": "Turner", "given": "Kristina", "initials": "K", "orcid": "0000-0002-0585-9207", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43081e9e652c4bd7a7a06d3289a5968c.json"}}, {"family": "O'Brien", "given": "Siobhan", "initials": "S"}, {"family": "Wallstr\u00f6m", "given": "Helena", "initials": "H"}, {"family": "Samuelsson", "given": "Katarina", "initials": "K"}, {"family": "Uusim\u00e4ki", "given": "Sirkka-Liisa Marjatta", "initials": "SM"}], "type": "journal article", "published": "2023-04-28", "journal": {"title": "Int J Educ Technol High Educ", "issn": "2365-9440", "issn-l": null, "volume": "20", "issue": "1", "pages": "25"}, "abstract": "This article reports on a study analysing changes in the use of digital technologies and working from home during the COVID-19 crisis and the impact of these changes on the wellbeing of five female university lecturers from Australia and Sweden. Applying collaborative autoethnographical methods, this study employed Weick's sensemaking framework to explore how the academics made sense of these sudden changes. The Positive emotion, Engagement, Relationships, Meaning, and Accomplishment (PERMA) wellbeing framework was also employed to explore the effect of these changes on the academics' wellbeing. Findings from the reflective narratives show that after the initial experiences of stress, each university lecturer was able to adapt and navigate the online teaching environment during the pandemic. However, the time constraints in preparing and adapting to online teaching, and working from home, were experienced by some of the university lecturers as highly stressful and isolating which impacted their sense of wellbeing. Even so, working from home was recognized as a positive experience, providing time for research, hobbies, and time with family. This study addresses a gap in current knowledge by examining the impact of the sudden transition to online teaching and learning had on academic wellbeing as conceptualised through the PERMA framework. In addition, by applying Weick's sensemaking framework, this study provides a unique perspective around how academics made sense of the sudden switch to online teaching and learning during COVID-19.", "doi": "10.1186/s41239-023-00395-5", "pmid": "37131502", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10139830"}, {"db": "pii", "key": "395"}], "notes": [], "created": "2023-10-04T05:11:08.068Z", "modified": "2023-10-04T07:07:32.243Z"}, {"entity": "publication", "iuid": "f85426a33bd547b5b2d964cd3f37287a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f85426a33bd547b5b2d964cd3f37287a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f85426a33bd547b5b2d964cd3f37287a"}}, "title": "Physical functioning post-COVID-19 and the recovery process: a mixed methods study.", "authors": [{"family": "Tofiq", "given": "Avin", "initials": "A", "orcid": "0000-0003-1712-7510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1460dc1501cf4a599430688991f6139f.json"}}, {"family": "Eriksson Crommert", "given": "Martin", "initials": "M"}, {"family": "Zakrisson", "given": "Ann-Britt", "initials": "AB", "orcid": "0000-0002-8370-8834", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc03287b22de4d27bb5d594b7e4ac7f3.json"}}, {"family": "von Euler", "given": "Mia", "initials": "M"}, {"family": "Nilsing Strid", "given": "Emma", "initials": "E", "orcid": "0000-0002-0483-8981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6022f01a844440ea4ca64f114b47058.json"}}], "type": "journal article", "published": "2023-04-20", "journal": {"title": "Disabil Rehabil", "issn": "1464-5165", "pages": "1-10", "issn-l": null}, "abstract": "To describe physical functioning after severe COVID-19-infection.\n\nAn explanatory sequential mixed method design was used. Thirty-nine participants performed tests and answered questionnaires measuring physical functioning six months after hospitalisation due to COVID-19. Thirty of these participants participated in semi-structured interviews with questions regarding how they perceived their physical functioning and recovery from COVID-19 at 12 months post-hospitalisation.\n\nAt six months, physical functioning measured via chair stand test and hip-worn accelerometers was lower than normal reference values. There was a reduction in breathing muscle strength. Participants estimated their functional status during different activities as lower compared to those before COVID-19-infection, measured with a patient-specific functional scale. At one year after infection, there were descriptions of a rough recovery process and remaining symptoms.\n\nPatients recovering from severe COVID-19 seem to have reduced physical functioning and activity levels, and they perceive their recovery to be slow and difficult. They experienced a lack of clinical support and contradictory advice regarding rehabilitation. Coaching in returning to physical functioning after the infection needs to be better co-ordinated and there is a need for guidelines for health professionals to avoid patients receiving contradictory advice.", "doi": "10.1080/09638288.2023.2201512", "pmid": "37078388", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [], "notes": [], "created": "2023-04-20T17:18:25.671Z", "modified": "2023-04-20T17:18:25.834Z"}, {"entity": "publication", "iuid": "355f4f39a9d045f09a4a8f7b1b5a5114", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/355f4f39a9d045f09a4a8f7b1b5a5114.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/355f4f39a9d045f09a4a8f7b1b5a5114"}}, "title": "Impairment of quality of life due to COVID-19-induced long-term olfactory dysfunction.", "authors": [{"family": "Winter", "given": "Anja L", "initials": "AL"}, {"family": "Henecke", "given": "Sofie", "initials": "S"}, {"family": "Lundstr\u00f6m", "given": "Johan N", "initials": "JN"}, {"family": "Thunell", "given": "Evelina", "initials": "E"}], "type": "journal article", "published": "2023-04-20", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "14", "issue": null, "pages": "1165911"}, "abstract": "Olfactory dysfunction is one of many long-lasting symptoms associated with COVID-19, estimated to affect approximately 60% of individuals and often lasting several months after infection. The associated daily life problems can cause a decreased quality of life.\r\n\r\nHere, we assessed the association between perceived quality of life and both qualitative and quantitative olfactory function (distorted and weakened sense of smell, respectively) in 58 individuals who had undergone confirmed SARS-CoV-2 infection and who complained about olfactory dysfunction.\r\n\r\nParticipants with large quantitative olfactory dysfunction experienced a greater reduction in their quality of life. Moreover, our participants had a high prevalence of qualitative olfactory dysfunction (81%) with a significant correlation between qualitative olfactory dysfunction and daily life impairment. Strong drivers of low quality of life assessments were lack of enjoyment of food as well as worries related to coping with long-term dysfunctions.\r\n\r\nThese results stress the clinical importance of assessing qualitative olfactory dysfunction and the need to develop relevant interventions. Given the poor self-rated quality of life observed, healthcare systems should consider developing support structures, dietary advice, and guidelines adapted to individuals experiencing qualitative olfactory dysfunction.", "doi": "10.3389/fpsyg.2023.1165911", "pmid": "37151341", "labels": {"Category: Post-COVID": null, "Funder: VR": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC10157159"}], "notes": [], "created": "2023-10-04T05:10:26.106Z", "modified": "2023-10-04T06:38:09.971Z"}, {"entity": "publication", "iuid": "a238c04e9e0549458fbbb0ef9cb9d776", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a238c04e9e0549458fbbb0ef9cb9d776.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a238c04e9e0549458fbbb0ef9cb9d776"}}, "title": "Self-care behaviours of patients with left ventricular assist devices in Israel: changes during the COVID-19 pandemic.", "authors": [{"family": "Melnikov", "given": "Semyon", "initials": "S"}, {"family": "Ben Avraham", "given": "Binyamin", "initials": "B"}, {"family": "Itzhaki Ben Zadok", "given": "Osnat", "initials": "O"}, {"family": "Shaul", "given": "Aviv", "initials": "A"}, {"family": "Abuhazira", "given": "Miri", "initials": "M"}, {"family": "Yaari", "given": "Vicky", "initials": "V"}, {"family": "Jaarsma", "given": "Tiny", "initials": "T"}, {"family": "Ben-Gal", "given": "Tuvia", "initials": "T"}], "type": "journal article", "published": "2023-04-19", "journal": {"title": "ESC Heart Fail", "issn": "2055-5822", "issn-l": null}, "abstract": "Left ventricular assist devices (LVADs) support the hearts of patients with advanced heart failure. Following LVAD implantation, patients face a complex regimen of self-care behaviours including self-care maintenance, self-care monitoring and self-care management. However, during the COVID-19 pandemic, symptoms of anxiety and depression may have interfered with their self-care. Currently, little is known on how specific self-care behaviours of LVAD-implanted patients changed during the COVID-19 pandemic. We aim to describe the changes in self-care behaviours among patients with an implanted LVAD in Israel during the COVID-19 pandemic and explore the factors related to self-care behaviour change.\n\nA prospective observational cross-sectional study design. A convenience sample of 27 Israeli LVAD-implanted patients (mean age 62.4 \u00b1 9, 86% male, 78.6% living with a partner) completed the LVAD Self-Care Behaviour Scale (1 = never to 5 = always) and Hospital Anxiety and Depression Scale (0 = not at all to 3 = most of the time). Data were collected before and after the onset of the COVID-19 pandemic in Israel. Statistical analyses included paired t-tests, Pearson's correlations, and one-way repeated measures ANOVAs.\n\nDuring the COVID-19 pandemic, a significant decrease was found in patients' adherence to checking and recording their LVAD speed, flow, power and PI (Pulsatility Index) (P = 0.05), checking their INR (P = 0.01), and daily weighing (P < 0.01). The prevalence of some behaviours (e.g. regularly exercising) increased in some patients and decreased in others. Patients living without a partner worsened their adherence to some of the self-care behaviours (e.g. taking medicines as prescribed), compared with those living with a partner (Mb = 5.0 \u00b1 0 and Md = 5.0 \u00b1 0, delta = 0 vs. Mb = 5.0 \u00b1 0 and Md = 4.6 \u00b1 0.9, delta = -0.4, respectively; F = 4.9, P = 0.04). Women, and not men, tended to improve their adherence to the self-care behaviour such as avoiding kinking, pulling, or moving the LVAD driveline at the exit site (Mb = 4.0 \u00b1 1.0 and Md = 5.0 \u00b1 0, delta = 1.0 vs. Mb = 4.5 \u00b1 0.9 and Md = 4.4 \u00b1 1.2, delta = -0.1, F = 4.7, P = 0.04, respectively). In total, 41% (11) patients reported neither anxiety nor depression, 11% (3) reported anxiety, 15% (4) reported depression, and 44% (12) reported both anxiety and depression. No associations between anxiety and/or depression and self-care behaviours were found.\n\nPriorities in self-care behaviours among patients with implanted LVAD changed after the onset of the COVID-19 pandemic. Factors that assisted with adherence to self-care behaviours included living with a partner and being female. The current results may guide further research on identifying behaviours that are at risk of not being maintained during a time of emergency.", "doi": "10.1002/ehf2.14376", "pmid": "37075748", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-20T17:20:14.850Z", "modified": "2023-04-20T17:20:14.854Z"}, {"entity": "publication", "iuid": "8a5bbed2693e49ad9287f37d8e9ffe0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a5bbed2693e49ad9287f37d8e9ffe0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a5bbed2693e49ad9287f37d8e9ffe0e"}}, "title": "The role of booster vaccination in decreasing COVID-19 age-adjusted case fatality rate: Evidence from 32 countries.", "authors": [{"family": "Zhou", "given": "Cui", "initials": "C"}, {"family": "Wheelock", "given": "\u00c5sa M", "initials": "\u00c5M"}, {"family": "Zhang", "given": "Chutian", "initials": "C"}, {"family": "Ma", "given": "Jian", "initials": "J"}, {"family": "Dong", "given": "Kaixing", "initials": "K"}, {"family": "Pan", "given": "Jingxiang", "initials": "J"}, {"family": "Li", "given": "Zhichao", "initials": "Z"}, {"family": "Liang", "given": "Wannian", "initials": "W"}, {"family": "Gao", "given": "Jing", "initials": "J"}, {"family": "Xu", "given": "Lei", "initials": "L"}], "type": "journal article", "published": "2023-04-18", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "1150095"}, "abstract": "The global COVID-19 pandemic is still ongoing, and cross-country and cross-period variation in COVID-19 age-adjusted case fatality rates (CFRs) has not been clarified. Here, we aimed to identify the country-specific effects of booster vaccination and other features that may affect heterogeneity in age-adjusted CFRs with a worldwide scope, and to predict the benefit of increasing booster vaccination rate on future CFR.\r\n\r\nCross-temporal and cross-country variations in CFR were identified in 32 countries using the latest available database, with multi-feature (vaccination coverage, demographic characteristics, disease burden, behavioral risks, environmental risks, health services and trust) using Extreme Gradient Boosting (XGBoost) algorithm and SHapley Additive exPlanations (SHAP). After that, country-specific risk features that affect age-adjusted CFRs were identified. The benefit of booster on age-adjusted CFR was simulated by increasing booster vaccination by 1-30% in each country.\r\n\r\nOverall COVID-19 age-adjusted CFRs across 32 countries ranged from 110 deaths per 100,000 cases to 5,112 deaths per 100,000 cases from February 4, 2020 to Jan 31, 2022, which were divided into countries with age-adjusted CFRs higher than the crude CFRs and countries with age-adjusted CFRs lower than the crude CFRs (n = 9 and n = 23) when compared with the crude CFR. The effect of booster vaccination on age-adjusted CFRs becomes more important from Alpha to Omicron period (importance scores: 0.03-0.23). The Omicron period model showed that the key risk factors for countries with higher age-adjusted CFR than crude CFR are low GDP per capita and low booster vaccination rates, while the key risk factors for countries with higher age-adjusted CFR than crude CFR were high dietary risks and low physical activity. Increasing booster vaccination rates by 7% would reduce CFRs in all countries with age-adjusted CFRs higher than the crude CFRs.\r\n\r\nBooster vaccination still plays an important role in reducing age-adjusted CFRs, while there are multidimensional concurrent risk factors and precise joint intervention strategies and preparations based on country-specific risks are also essential.", "doi": "10.3389/fpubh.2023.1150095", "pmid": "37143970", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10151823"}], "notes": [], "created": "2023-10-04T05:12:06.882Z", "modified": "2023-10-04T07:28:47.537Z"}, {"entity": "publication", "iuid": "45834f0045954b6280dea027a997784b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/45834f0045954b6280dea027a997784b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/45834f0045954b6280dea027a997784b"}}, "title": "Plasmablasts in previously immunologically na\u00efve COVID-19 patients express markers indicating mucosal homing and secrete antibodies cross-reacting with SARS-CoV-2 variants and other beta-coronaviruses.", "authors": [{"family": "Lundgren", "given": "Anna", "initials": "A"}, {"family": "Leach", "given": "Susannah", "initials": "S", "orcid": "0000-0002-9614-2753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18d00be831d241dca238b3253d1b45f6.json"}}, {"family": "Axelsson", "given": "Hannes", "initials": "H"}, {"family": "Isakson", "given": "Pauline", "initials": "P"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Scharf", "given": "Lydia", "initials": "L"}, {"family": "Andersson", "given": "Bengt A", "initials": "BA"}, {"family": "Miron", "given": "Nicolae", "initials": "N"}, {"family": "Marklund", "given": "Emelie", "initials": "E"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Gisslen", "given": "Magnus", "initials": "M"}, {"family": "Angeletti", "given": "Davide", "initials": "D"}, {"family": "Bemark", "given": "Mats", "initials": "M", "orcid": "0000-0001-7416-9819", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ae923943b6c4b4bb74ca1e14b426351.json"}}], "type": "journal article", "published": "2023-04-18", "journal": {"title": "Clin Exp Immunol", "issn": "1365-2249", "issn-l": null}, "abstract": "Antigen-specific class-switched antibodies are detected at the same time or even before IgM in serum of non-vaccinated individuals infected with SARS-CoV-2. These derive from the first wave of plasmablasts formed. The phenotype and specificity of plasmablasts can reveal information about early B cell activation. Here we have analyzed B cells and plasmablasts circulating in blood of COVID-19 patients not previously exposed to SARS-CoV-2 during and after disease. We find that during infection with the original Wuhan strain, plasmablasts in blood produce IgA1, IgG1 and IgM, and that most express CCR10 and integrin \u03b21, only some integrin \u03b27, while the majority lack CCR9. Plasmablast-secreted antibodies are reactive to the Spike (S) and Nucleocapsid (N) proteins of the Wuhan strain as well as later variants of concern, but also bind S proteins from endemic and non-circulating betacoronaviruses. In contrast, after recovery, antibodies produced from memory B cells target variants of SARS-CoV-2 and SARS-CoV-1 but compared to previously non-infected individuals do not show increased binding to endemic coronaviruses. This suggests that the early antibody response to a large extent stems from pre-existing cross-reactive class-switched memory B cells, but that that although newly formed memory cells target the novel SARS-CoV-2 virus the numbers of broadly cross-reactive memory B cells do not increase extensively. The observations give insight into the role of pre-existing memory B cells in early antibody responses to novel pathogens and may explain why class-switched antibodies are detected early in serum of COVID-19 patients.", "doi": "10.1093/cei/uxad044", "pmid": "37071584", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "7127793"}], "notes": [], "created": "2023-04-20T17:21:24.291Z", "modified": "2023-04-20T17:21:48.207Z"}, {"entity": "publication", "iuid": "a7144432b32143a1949e61e162ef5874", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7144432b32143a1949e61e162ef5874.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7144432b32143a1949e61e162ef5874"}}, "title": "Contact allergy investigations in healthcare workers with face mask-related skin disease.", "authors": [{"family": "Brynolf", "given": "Andreas", "initials": "A", "orcid": "0009-0008-9710-8048", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e085284ebd94b34892969d3c8b364f0.json"}}, {"family": "Hauksson", "given": "Inese", "initials": "I"}, {"family": "Bergendorff", "given": "Ola", "initials": "O"}, {"family": "Svedman", "given": "Cecilia", "initials": "C", "orcid": "0000-0003-4797-0269", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fda1bd9c72f346e499ff64aef7394a56.json"}}, {"family": "Hamnerius", "given": "Nils", "initials": "N", "orcid": "0000-0001-5188-7711", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee788e8a5610497c9ef14e0860375614.json"}}], "type": "journal article", "published": "2023-04-18", "journal": {"title": "Contact Dermatitis", "issn": "1600-0536", "issn-l": null}, "abstract": "During the COVID-19 pandemic, the use of face masks has increased among healthcare workers (HCWs). Questionnaire studies have shown a high frequency of self-reported facial adverse skin reactions. Case reports have been published on face mask-induced allergic contact dermatitis and urticaria.\n\nTo describe the results of the contact allergy investigations in consecutive HCWs investigated for skin reactions to face masks during the COVID-19 pandemic and the results of the chemical investigations of face masks supplied by the hospital.\n\nParticipants were patch tested with baseline series and chemicals previously reported in face masks not included in the baseline series. Face mask(s) brought by the HCW were tested as is and/or in acetone extract. Chemical analyses were performed on nine different face masks for potential allergens.\n\nFifty-eight HCWs were investigated. No contact allergies were found to the face mask(s) tested. Eczema was the most common type of skin reaction, followed by an acneiform reaction. Colophonium-related substances were found in one respirator and 2,6-di-t-butyl-4-methylphenol (BHT) were found in two respirators.\n\nBased on this report, contact allergies to face masks is uncommon. Patch test with colophonium-related substances and BHT should be considered when investigating adverse skin reactions to face masks.", "doi": "10.1111/cod.14318", "pmid": "37072615", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-20T17:20:30.491Z", "modified": "2023-04-20T17:20:30.634Z"}, {"entity": "publication", "iuid": "17cd812532714081a54e15e64974b1a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/17cd812532714081a54e15e64974b1a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/17cd812532714081a54e15e64974b1a0"}}, "title": "Perceived effects of the COVID-19 pandemic on clinical psychology internships in Sweden.", "authors": [{"family": "Bergvall", "given": "Hillevi", "initials": "H", "orcid": "0000-0003-4091-0757", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41be49533571498f99e4542697b14c65.json"}}, {"family": "Larsson", "given": "Cornelia", "initials": "C", "orcid": "0000-0002-3860-0031", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6b2ff2a74f94af4936beb9bf511c9de.json"}}, {"family": "Str\u00e5lin", "given": "Elinor Eskilsson", "initials": "EE", "orcid": "0000-0002-1194-0968", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29195ee7e8b8468dad955f63f4308f5d.json"}}, {"family": "Bohman", "given": "Benjamin", "initials": "B", "orcid": "0000-0002-3415-7511", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/691b47f0c00d431eb46863b5f5c4b5d2.json"}}, {"family": "Alfonsson", "given": "Sven", "initials": "S", "orcid": "0000-0003-4570-5891", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c3e238a169547c596d13c7199defb7a.json"}}], "type": "journal article", "published": "2023-04-17", "journal": {"title": "BMC Med Educ", "issn": "1472-6920", "volume": "23", "issue": "1", "pages": "249", "issn-l": null}, "abstract": "The COVID-19 pandemic has had an unprecedented impact on societies and health care services worldwide, including the clinical training of psychology interns. Some of the pandemic-related restrictions were in breach of the internship requirements, increasing the risk of failed internships and a shortage of new health care professionals. This situation needed to be assessed.\n\nWeb-based surveys were administered to clinical psychology interns in Sweden 2020 (n = 267) and 2021 (n = 340), as well as to supervisors in 2020 (n = 240). The supervisors also provided information about their interns (n = 297).\n\nRisk factors for a prolonged internship, such as pandemic-related absence from work (12.4% in 2020 and 7.9% in 2021), unqualified work (0% in 2020, 3% in 2021), and change in internship content were low. However, remote interactions using digital services increased. Face-to-face patient contacts decreased significantly from 2020 to 2021 (\u03a72 = 5.17, p = .023), while remote work and remote supervision increased significantly (\u03a72 = 53.86, p < .001 and \u03a72 = 8.88, p = .003, respectively). Still, the content in patient contacts and supervision was maintained. Most interns reported no difficulties with remote supervision or supervision in personal protective equipment. However, of the interns who reported difficulties, role-play and skills training in remote supervision were perceived as significantly harder (\u03a72 = 28.67, p < .001) than in supervision using personal protective equipment.\n\nThe present study indicates that clinical training of psychology interns in Sweden could proceed despite a societal crisis. Results suggest that the psychology internship was flexible in the sense that it could be realized in combined face-to-face and remote formats without losing much of its value. However, the results also suggest that some skills may be harder to train in remote supervision.", "doi": "10.1186/s12909-023-04236-x", "pmid": "37069581", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12909-023-04236-x"}, {"db": "pmc", "key": "PMC10106869"}], "notes": [], "created": "2023-04-20T17:22:13.234Z", "modified": "2023-04-20T17:22:13.409Z"}, {"entity": "publication", "iuid": "469629c631504233b7d149d25ba0b295", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/469629c631504233b7d149d25ba0b295.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/469629c631504233b7d149d25ba0b295"}}, "title": "Impact of the COVID-19 pandemic on sick leave among healthcare workers: a register-based observational study.", "authors": [{"family": "Reme", "given": "Bj\u00f8rn-Atle", "initials": "BA"}, {"family": "Gr\u00f8sland", "given": "Mari", "initials": "M", "orcid": "0000-0001-6992-0620", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b6e933f49c14291aaee6aec14079e70.json"}}, {"family": "Gjefsen", "given": "Hege", "initials": "H"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2023-04-17", "journal": {"title": "Occup Environ Med", "issn": "1470-7926", "issn-l": null}, "abstract": "To assess the impact of the COVID-19 pandemic on sick leave among healthcare workers (HCWs) in primary and specialist care and examine its causes.\n\nUsing individual-level register data, we studied monthly proportions of sick leave (all-cause and not related to SARS-CoV-2 infection) from 2017 to February 2022 for all HCWs in primary (N=60 973) and specialist care (N=34 978) in Norway. First, we estimated the impact of the pandemic on sick leave, by comparing the sick leave rates during the pandemic to sick leave rates in 2017-2019. We then examined the impact of COVID-19-related workload on sick leave, by comparing HCWs working in healthcare facilities with different levels of COVID-19 patient loads.\n\nHCWs had elevated monthly rates of all-cause sick leave during the COVID-19 pandemic of 2.8 (95% CI 2.67 to 2.9) and 2.2 (95% CI 2.07 to 2.35) percentage points in primary and specialist care. The corresponding increases for sick leave not related to SARS-CoV-2 infection were 1.2 (95% CI 1.29 to 1.05) and 0.7 (95% CI 0.52 to 0.78) percentage points. All-cause sick leave was higher in areas with high versus low COVID-19 workloads. However, after removing sick leave episodes due to SARS-CoV-2 infections, there was no difference.\n\nThere was a substantial increase in sick leave among HCWs during the pandemic. Our results suggest that the increase was due to HCWs becoming infected with SARS-CoV-2 and/or sector-wide effects, such as strict infection control measures. More differentiated countermeasures should, therefore, be evaluated to limit capacity constraints in healthcare provision.", "doi": "10.1136/oemed-2022-108555", "pmid": "37068949", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "oemed-2022-108555"}], "notes": [], "created": "2023-04-20T17:22:31.021Z", "modified": "2023-04-20T17:22:39.702Z"}, {"entity": "publication", "iuid": "25bbb9029a374ed995bb6332097b568e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/25bbb9029a374ed995bb6332097b568e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/25bbb9029a374ed995bb6332097b568e"}}, "title": "Myeloperoxidase Inhibition in Heart Failure With Preserved or Mildly Reduced Ejection Fraction: SATELLITE Trial Results.", "authors": [{"family": "Lam", "given": "Carolyn S P", "initials": "CSP"}, {"family": "Lund", "given": "Lars H", "initials": "LH"}, {"family": "Shah", "given": "Sanjiv J", "initials": "SJ"}, {"family": "Voors", "given": "Adriaan A", "initials": "AA"}, {"family": "Erlinge", "given": "David", "initials": "D"}, {"family": "Saraste", "given": "Antti", "initials": "A"}, {"family": "Pirazzi", "given": "Carlo", "initials": "C"}, {"family": "Grove", "given": "Erik L", "initials": "EL"}, {"family": "Barasa", "given": "Anders", "initials": "A"}, {"family": "Schou", "given": "Morten", "initials": "M"}, {"family": "Aziz", "given": "Ahmed", "initials": "A"}, {"family": "Svedlund", "given": "Sara", "initials": "S"}, {"family": "Wijngaarden", "given": "Jan VAN", "initials": "JV"}, {"family": "Lindstedt", "given": "Eva-Lotte", "initials": "EL"}, {"family": "Gustavsson", "given": "Andreas", "initials": "A"}, {"family": "Nelander", "given": "Karin", "initials": "K"}, {"family": "Garkaviy", "given": "Pavlo", "initials": "P"}, {"family": "Gan", "given": "Li-Ming", "initials": "LM"}, {"family": "Gabrielsen", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2023-04-16", "journal": {"title": "J Card Fail", "issn": "1532-8414", "issn-l": null}, "abstract": "Inflammation is a key driver of heart failure (HF) with preserved left ventricular ejection fraction (LVEF). AZD4831 inhibits extracellular myeloperoxidase, reduces inflammation and improves microvascular function in preclinical disease models.\n\nIn this double-blind phase 2a study (SATELLITE; NCT03756285), patients with symptomatic HF, LVEF \u226540%, and elevated B-type natriuretic peptides were randomized 2:1 to once-daily oral AZD4831 5 mg or placebo for 90 days. We aimed to assess target engagement (primary endpoint: myeloperoxidase specific activity) and safety of AZD4831.\n\nDue to COVID-19, the study was terminated early after randomizing 41 patients (median age, 74.0 years; 53.7% male). Myeloperoxidase activity was reduced by >50% from baseline to day 30 and 90 in the AZD4831 group, with a placebo-adjusted reduction of 75% (95% confidence interval: 48, 88; nominal P <0.001). No improvements were noted in secondary/exploratory endpoints, apart from a trend in Kansas City Cardiomyopathy Questionnaire overall summary score. No deaths or treatment-related serious adverse events occurred. AZD4831 treatment-related adverse events were generalized maculopapular rash, pruritus and diarrhoea (all n=1).\n\nAZD4831 inhibited myeloperoxidase and was well tolerated in patients with HF and LVEF \u226540%. Efficacy findings were exploratory due to early termination but warrant further clinical investigation of AZD4831.\n\nFew treatments are available for patients with the forms of heart failure known as 'heart failure with preserved or mildly reduced ejection fraction'. Current treatments do not target inflammation, which may play an important role in this condition. We tested a new drug called AZD4831 (mitiperstat), which reduces inflammation by inhibiting the enzyme myeloperoxidase. Among the 41 patients in our clinical trial, AZD4831 had a good safety profile and inhibited myeloperoxidase by the expected amount. Results mean we can conduct further trials to see whether AZD4831 reduces the symptoms of heart failure and improves patients' ability to take physical exercise.", "doi": "10.1016/j.cardfail.2023.04.003", "pmid": "37072105", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1071-9164(23)00142-2"}], "notes": [], "created": "2023-04-20T17:20:48.792Z", "modified": "2023-04-20T17:20:48.822Z"}, {"entity": "publication", "iuid": "60c043206a064d22b94115553cd77baa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60c043206a064d22b94115553cd77baa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60c043206a064d22b94115553cd77baa"}}, "title": "Nurses and global health responsibility: In light of the COVID-19 pandemic and the war in Ukraine.", "authors": [{"family": "Lindberg", "given": "Catharina", "initials": "C", "orcid": "0000-0001-7552-2717", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c36291c5c6394f01beddc951f2272b88.json"}}, {"family": "Brinchmann", "given": "Berit St\u00f8re", "initials": "BS", "orcid": "0000-0001-6541-4931", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6ed725c0172415f836219836632d987.json"}}], "type": "journal article", "published": "2023-04-15", "journal": {"title": "Int Nurs Rev", "issn": "1466-7657", "issn-l": null}, "abstract": "The aim of this paper was to reflect on global ethical challenges for nurses in light of the COVID-19 pandemic and the war in Ukraine and to discuss 'Nurses and Global Health', a new element in the revised ICN Code of Ethics for Nurses, 2021, and its implications for nurses.\n\nThe authors participated in the latest revision of the Code. When we were revising the ICN Code of Ethics, there was neither an ongoing pandemic nor a war in Europe.\n\nRelevant scientific articles and other academic literature, documents from international organisations, and authors' views.\n\nThe discussion emanated from our reflections on how to actually apply the ICN Code of Ethics, i.e., moving the words from the document itself into everyday practice, in light of the COVID-19 pandemic and the war in Ukraine. In the Code, the nurse's responsibility is highlighted, but there is little or no instruction on how to undertake it.\n\nThe ICN Code of Ethics needs to be operationalised through ethical reflection and discussion in all contexts where nurses work, from policy level to the care environment.", "doi": "10.1111/inr.12844", "pmid": "37060544", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-20T17:23:49.316Z", "modified": "2023-04-20T17:23:49.402Z"}, {"entity": "publication", "iuid": "89c2bbb82ff644319505cb83111e7a28", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/89c2bbb82ff644319505cb83111e7a28.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/89c2bbb82ff644319505cb83111e7a28"}}, "title": "Delayed generation of functional virus-specific circulating T follicular helper cells correlates with severe COVID-19.", "authors": [{"family": "Yu", "given": "Meng", "initials": "M", "orcid": "0000-0002-9798-6624", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b6ab0fe226324dddbb38d008f92767de.json"}}, {"family": "Charles", "given": "Afandi", "initials": "A", "orcid": "0000-0003-0022-3303", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f96e5b81f0ee44938ebf4123dffeba1e.json"}}, {"family": "Cagigi", "given": "Alberto", "initials": "A"}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f2dc27d02294a15a6f691be6aab641f.json"}}, {"family": "\u00d6sterberg", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Falck-Jones", "given": "Sara", "initials": "S"}, {"family": "Azizmohammadi", "given": "Lida", "initials": "L"}, {"family": "\u00c5hlberg", "given": "Eric", "initials": "E"}, {"family": "Falck-Jones", "given": "Ryan", "initials": "R", "orcid": "0000-0002-0985-8658", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b100f8839744b7681180a84162a1625.json"}}, {"family": "Svensson", "given": "Julia", "initials": "J"}, {"family": "Nie", "given": "Mu", "initials": "M"}, {"family": "Warnqvist", "given": "Anna", "initials": "A"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Lenart", "given": "Klara", "initials": "K", "orcid": "0000-0002-4984-2618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/695f9cad72624d87a09626b8097d654d.json"}}, {"family": "Arcoverde Cerveira", "given": "Rodrigo", "initials": "R", "orcid": "0000-0002-1145-2534", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/967497a8624d4a889ba820aa8fe42336.json"}}, {"family": "Ols", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-9784-7176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35eb7b8de6434661a729bab979f26c7d.json"}}, {"family": "Lindgren", "given": "Gustaf", "initials": "G"}, {"family": "Lin", "given": "Ang", "initials": "A"}, {"family": "Maecker", "given": "Holden", "initials": "H", "orcid": "0000-0003-0795-9946", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f643c4e99634951a332a6757953878f.json"}}, {"family": "Bell", "given": "Max", "initials": "M", "orcid": "0000-0001-7464-0324", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/530f7609a1f143b69691db5c41b14412.json"}}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Albert", "given": "Jan", "initials": "J", "orcid": "0000-0001-9020-0521", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79a6c7eedadb4a1e8c6fd7b8b522a8e3.json"}}, {"family": "Sundling", "given": "Christopher", "initials": "C", "orcid": "0000-0002-6138-690X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/95f99b6d6c464221919a437b88b46b54.json"}}, {"family": "Czarnewski", "given": "Paulo", "initials": "P"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "F\u00e4rnert", "given": "Anna", "initials": "A"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K", "orcid": "0000-0001-7679-9494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02d4d3d9ccc547f7ab18ba69493f6a34.json"}}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A", "orcid": "0000-0001-6966-7039", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0c96bf27aca45f6b460a555c5425e2d.json"}}], "type": "journal article", "published": "2023-04-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "2164", "issn-l": "2041-1723"}, "abstract": "Effective humoral immune responses require well-orchestrated B and T follicular helper (Tfh) cell interactions. Whether these interactions are impaired and associated with COVID-19 disease severity is unclear. Here, longitudinal blood samples across COVID-19 disease severity are analysed. We find that during acute infection SARS-CoV-2-specific circulating Tfh (cTfh) cells expand with disease severity. SARS-CoV-2-specific cTfh cell frequencies correlate with plasmablast frequencies and SARS-CoV-2 antibody titers, avidity and neutralization. Furthermore, cTfh cells but not other memory CD4 T cells, from severe patients better induce plasmablast differentiation and antibody production compared to cTfh cells from mild patients. However, virus-specific cTfh cell development is delayed in patients that display or later develop severe disease compared to those with mild disease, which correlates with delayed induction of high-avidity neutralizing antibodies. Our study suggests that impaired generation of functional virus-specific cTfh cells delays high-quality antibody production at an early stage, potentially enabling progression to severe disease.", "doi": "10.1038/s41467-023-37835-9", "pmid": "37061513", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10105364"}, {"db": "pii", "key": "10.1038/s41467-023-37835-9"}], "notes": [], "created": "2023-04-17T14:41:16.708Z", "modified": "2023-04-20T17:23:35.166Z"}, {"entity": "publication", "iuid": "a2c1bd96eca245a49b5934f9d2949300", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2c1bd96eca245a49b5934f9d2949300.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2c1bd96eca245a49b5934f9d2949300"}}, "title": "SARS-CoV-2 Antibodies in Commercial Immunoglobulin Products Show Markedly Reduced Cross-reactivities Against Omicron Variants.", "authors": [{"family": "Lindahl", "given": "Hannes", "initials": "H", "orcid": "0000-0002-4447-9426", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae08b00dd81545eab451b58ce0c0481b.json"}}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE"}, {"family": "Bergman", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2023-04-14", "journal": {"title": "J Clin Immunol", "issn": "1573-2592", "pages": "1-8", "issn-l": "0271-9142"}, "abstract": "Patients with antibody deficiencies often receive maintenance treatment with donor plasma-derived immunoglobulin (Ig) preparations to decrease the incidence and severity of infections. We have previously shown that IgG antibodies to the original SARS-CoV-2 strain were not consistently present in off-the-shelf Ig batches produced up to approximately 18 months after the first identified case of COVID-19 in the USA and that Ig batches with anti-SARS-CoV-2 IgG primarily contained vaccine-induced spike specific antibodies. This study aimed to investigate the degree of cross-reactivity between vaccine-induced anti-SARS-CoV-2 antibodies against Wuhan strain and subsequent viral variants.\n\nSamples were collected from 74 Ig batches supplied by three different commercial manufacturers. All batches were used at the Immunodeficiency Unit at the Karolinska University Hospital from the start of the SARS-CoV-2 pandemic until September 2022. Antibody quantity and potential to neutralize virus entry into host cells were assessed against the original SARS-CoV-2 Wuhan strain and the following nine variants: Alpha, Beta, Delta, IHU, and the Omicron BA.1, BA.1.1, BA.1 with spike mutation L452R, BA.2, and BA.3.\n\nIg batches produced approximately 18 months after the SARS-CoV-2 outbreak (from around July 2021) and later consistently contained high quantities of antibodies that bind the Wuhan strain. The Ig batches had overall low reactivity to the SARS-CoV-2 nucleocapsid, which implies that plasma donor spike IgG essentially is the result of vaccination. We assessed the degree of cross-reactivity towards each virus variant by plotting the variant/Wuhan strain ratio, which was consistent regardless of production date, suggesting cross-reactivity with vaccine-induced antibodies rather than virus exposure in the plasma donor population. Viral variants that emerged later during the pandemic systematically had a lower reactivity ratio, except for the Delta and IHU variants. The Ig batches displayed markedly low neutralizing potential towards the Beta variant and all tested Omicron variants.\n\nCommercial Ig batches currently contain large quantities of SARS-CoV-2 vaccine-induced antibodies. Cross-reactivity with variant strains is evident but varies, with markedly low neutralizing potential observed against Omicron variants.", "doi": "10.1007/s10875-023-01486-8", "pmid": "37058198", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10102687"}, {"db": "pii", "key": "10.1007/s10875-023-01486-8"}], "notes": [], "created": "2023-04-20T17:24:45.566Z", "modified": "2023-04-20T17:25:41.233Z"}, {"entity": "publication", "iuid": "fcd7bbf7cd1043369c2e770f00871b66", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fcd7bbf7cd1043369c2e770f00871b66.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fcd7bbf7cd1043369c2e770f00871b66"}}, "title": "Impact of SARS-CoV-2 vaccination and monoclonal antibodies on outcome post CD19-CAR-T: an EPICOVIDEHA survey.", "authors": [{"family": "van Doesum", "given": "Jaap A", "initials": "JA", "orcid": "0000-0003-0214-3219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49152311cb004139904554d1c096c05c.json"}}, {"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J", "orcid": "0000-0002-6766-8297", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dea501020d2042ad83d1b024987792f4.json"}}, {"family": "Marchesi", "given": "Francesco", "initials": "F"}, {"family": "Di Blasi", "given": "Roberta", "initials": "R", "orcid": "0000-0001-9001-573X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b0e256f42ad4d25aef901a2c2df7eab.json"}}, {"family": "Falces-Romero", "given": "Iker", "initials": "I"}, {"family": "Cabirta", "given": "Alba", "initials": "A", "orcid": "0000-0001-7198-8894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ca8361c64eb4563a0f090faaf569e8a.json"}}, {"family": "Farina", "given": "Francesca", "initials": "F"}, {"family": "Besson", "given": "Caroline", "initials": "C", "orcid": "0000-0003-4364-7173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adc322a60efe4963a3ff76aa00c885d6.json"}}, {"family": "Weinbergerov\u00e1", "given": "Barbora", "initials": "B", "orcid": "0000-0001-6460-2471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7ef50b8f8dc457ab2badd8481b3fa86.json"}}, {"family": "Van Praet", "given": "Jens", "initials": "J", "orcid": "0000-0002-7125-7001", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ebcaace10774e8c8727b0638e5ec075.json"}}, {"family": "Sch\u00f6nlein", "given": "Martin", "initials": "M", "orcid": "0000-0002-1010-0975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bc914f4fd004b8695f47c8ef5373941.json"}}, {"family": "Lopez-Garcia", "given": "Alberto", "initials": "A"}, {"family": "Lamure", "given": "Sylvain", "initials": "S"}, {"family": "Guidetti", "given": "Anna", "initials": "A"}, {"family": "De Ram\u00f3n-S\u00e1nchez", "given": "Cristina", "initials": "C", "orcid": "0000-0002-8167-6410", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d42267ab742491d95080c6592197d6a.json"}}, {"family": "Batinic", "given": "Josip", "initials": "J"}, {"family": "Gavriilaki", "given": "Eleni", "initials": "E", "orcid": "0000-0002-8883-8208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5c146006910e4affb970a1ffe9db5989.json"}}, {"family": "Tragiannidis", "given": "Athanasios", "initials": "A"}, {"family": "Tisi", "given": "Maria Chiara", "initials": "MC"}, {"family": "Plantefeve", "given": "Ga\u00ebtan", "initials": "G"}, {"family": "Petzer", "given": "Verena", "initials": "V", "orcid": "0000-0002-9205-1440", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b52c652fbe2245d1a3df0ca220d8ad98.json"}}, {"family": "Ormazabal-Velez", "given": "Irati", "initials": "I"}, {"family": "Marques de Almeida", "given": "Joyce", "initials": "J", "orcid": "0000-0002-0270-3805", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2459904a9cfe4ea78217373c8af0bea1.json"}}, {"family": "Marchetti", "given": "Monia", "initials": "M"}, {"family": "Maertens", "given": "Johan A", "initials": "JA", "orcid": "0000-0003-4257-5980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4701b45871ba4030a2c57c01edcbf6e0.json"}}, {"family": "Machado", "given": "Marina", "initials": "M", "orcid": "0000-0002-8370-2248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/333e7bffca6c41be995da05411c11248.json"}}, {"family": "Kulasekararaj", "given": "Austin G", "initials": "AG", "orcid": "0000-0003-3180-3570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd4719161efc4d939fe6f4832430a1bc.json"}}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jos\u00e9 \u00c1ngel", "initials": "J\u00c1"}, {"family": "Gomes da Silva", "given": "Maria", "initials": "M", "orcid": "0000-0002-6993-2450", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75ea48d40e3647f189db6f726b4819bc.json"}}, {"family": "Fern\u00e1ndez", "given": "Noem\u00ed", "initials": "N"}, {"family": "Espigado", "given": "Ildefonso", "initials": "I", "orcid": "0000-0002-4043-6613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40c943f7cd0e40998a4a1ae519a39e48.json"}}, {"family": "Drgona", "given": "Lubos", "initials": "L", "orcid": "0000-0002-5089-3201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/746b17dbdf2a4b178e6a11454778c725.json"}}, {"family": "Dragonetti", "given": "Giulia", "initials": "G"}, {"family": "Metafuni", "given": "Elisabetta", "initials": "E", "orcid": "0000-0002-4780-1273", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96f59852bc434fb6968356ec092e911b.json"}}, {"family": "Calbacho", "given": "Maria", "initials": "M"}, {"family": "Blennow", "given": "Ola", "initials": "O", "orcid": "0000-0002-7167-7882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2318c3973e66443aa14fceca0908d127.json"}}, {"family": "Wolf", "given": "Dominik", "initials": "D"}, {"family": "van Anrooij", "given": "Bjorn", "initials": "B"}, {"family": "Nunes Rodrigues", "given": "Raquel", "initials": "R"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Mart\u00edn-Gonz\u00e1lez", "given": "Juan-Alberto", "initials": "JA", "orcid": "0000-0002-3734-921X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a309fa9dc9d4f1c93bd9821205a2f72.json"}}, {"family": "Lievin", "given": "Rapha\u00ebl", "initials": "R", "orcid": "0000-0002-5097-591X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d190434cf5f428f9714a761a1b67889.json"}}, {"family": "Jim\u00e9nez", "given": "Moraima", "initials": "M", "orcid": "0000-0003-1444-8562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c9e09b030ce4f8480230679f8c643be.json"}}, {"family": "Grafe", "given": "Stefanie K", "initials": "SK", "orcid": "0000-0001-7678-0179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6f9279444f64b529761a37a0d2448f4.json"}}, {"family": "Garcia-Sanz", "given": "Ramon", "initials": "R"}, {"family": "C\u00f3rdoba", "given": "Ra\u00fal", "initials": "R"}, {"family": "Rahimli", "given": "Laman", "initials": "L"}, {"family": "van Meerten", "given": "Tom", "initials": "T"}, {"family": "Cornely", "given": "Oliver A", "initials": "OA", "orcid": "0000-0001-9599-3137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3c62d8346924e69b6c99e4007c3831c.json"}}, {"family": "Pagano", "given": "Livio", "initials": "L", "orcid": "0000-0001-8287-928X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbf92a9779614910aeafcc6c21d880e2.json"}}], "type": "journal article", "published": "2023-04-14", "journal": {"title": "Blood Adv", "issn": "2473-9537", "issn-l": null}, "abstract": "Patients with previous CD19 directed chimeric antigen receptor T cell therapy (CAR T)-cell therapy have a prolonged vulnerability to viral infections. Coronavirus diseases 2019 (COVID-19) has a great impact and has previously been shown to cause high mortality in this population. Until now, real world data of the impact of vaccination and treatment on patients with COVID-19 after CD19 directed CAR T-cell therapy are lacking. Therefore, this multicenter retrospective study was conducted with data from the EPICOVIDEHA survey. Sixty-four patients were identified. The overall mortality caused by COVID-19 was 31%. Patients infected with the Omicron variant had a significantly lower risk of death due to COVID-19 compared to patients infected with previous variants (7% versus 58% (P=0.012)). Twenty-six patients were vaccinated at time of COVID-19 diagnosis. Two vaccinations showed marked but unsignificant reduction risk of COVID-19 caused mortality (33.3% versus 14.2% (P=0.379)).Also the course of disease appears milder with less frequent ICU admissions (39% versus 14% (P=0.054)) and shorter duration of hospitalization (7 versus 27.5 days (P=0.022)). Of the available treatment options, only monoclonal antibodies seemed to be effectively reducing mortality from 32% to zero (P=0.036). We conclude that survival rates of CAR T-cell recipients with COVID-19 improved over time and that the combination of prior vaccination and monoclonal antibody treatment significantly reduces their risk of death.", "doi": "10.1182/bloodadvances.2022009578", "pmid": "37058479", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "495340"}], "notes": [], "created": "2023-04-20T17:24:06.886Z", "modified": "2023-04-20T17:25:18.658Z"}, {"entity": "publication", "iuid": "e61559363def444894ce2eac0fa0c060", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e61559363def444894ce2eac0fa0c060.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e61559363def444894ce2eac0fa0c060"}}, "title": "Better Anti-Spike IgG Antibody Response to SARS-CoV-2 Vaccine in Patients on Haemodiafiltration than on Haemodialysis.", "authors": [{"family": "Carrera", "given": "Fernando", "initials": "F"}, {"family": "Jacobson", "given": "Stefan H", "initials": "SH"}, {"family": "Costa", "given": "Joana", "initials": "J"}, {"family": "Marques", "given": "Marco", "initials": "M"}, {"family": "Ferrer", "given": "Francisco", "initials": "F"}], "type": "journal article", "published": "2023-04-14", "journal": {"title": "Blood Purif", "issn": "1421-9735", "pages": "1-8", "issn-l": null}, "abstract": "The antibody response to SARS-CoV-2 vaccine in haemodialysis (HD) patients is diminished compared to healthy subjects. The aim of this study was to compare the presence of reactive SARS-CoV-2 antibodies in patients with high-flux HD and on-line haemodiafiltration (HDF) three and 6 months after the second dose of SARS-CoV-2 vaccine since previous studies indicate that a sustained antibody response correlates with protection from disease.\n\nWe included 216 HD patients of which 157 had on-line HDF and 59 high-flux HD and 46 health care workers as controls and studied the presence of reactive anti-spike IgG antibodies three and 6 months after the second dose of SARS-CoV-2 vaccine. Clinical features between the patient groups were similar, but patients with on-line HDF had significantly higher Kt/V.\n\nThe percentage of participants with reactive antibodies was significantly lower in patients compared to controls, both three and 6 months after the second dose of vaccine. Furthermore, the proportion of patients with reactive anti-spike IgG \u22651.0 6 months after the second dose of vaccine was significantly higher in patients with on-line HDF compared to in patients with high-flux HD. In logistic regression analyses adjusted for several clinical features, the variables associated with presence of reactive anti-spike IgG at 3 months after the second dose of vaccine were lower age, HDF treatment, not being obese and not having a previous solid organ transplant. The two variables with the strongest influence on the presence of reactive anti-spike IgG levels 6 months after the second dose of vaccine were treatment with on-line HDF and not having immunosuppressive therapy.\n\nThis is the first study to show that on-line HDF preserves the antibody response better than high-flux HD after vaccination with SARS-CoV-2 vaccine. Treatment strategies that sustain the vaccine response are essential to apply in this vulnerable group of patients.", "doi": "10.1159/000529719", "pmid": "37062269", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "000529719"}], "notes": [], "created": "2023-04-20T17:23:13.282Z", "modified": "2023-04-20T17:23:13.295Z"}, {"entity": "publication", "iuid": "98d740c575f5461fb34c0f42799c3a1c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/98d740c575f5461fb34c0f42799c3a1c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/98d740c575f5461fb34c0f42799c3a1c"}}, "title": "Prevalence of long COVID complaints in persons with and without COVID-19.", "authors": [{"family": "Magnusson", "given": "Karin", "initials": "K"}, {"family": "Turkiewicz", "given": "Aleksandra", "initials": "A"}, {"family": "Flottorp", "given": "Signe Agnes", "initials": "SA"}, {"family": "Englund", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2023-04-13", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "13", "issue": "1", "pages": "6074", "issn-l": "2045-2322"}, "abstract": "We studied the prevalence and patterns of typical long COVID complaints in ~ 2.3 million individuals aged 18-70 years with and without confirmed COVID-19 in a Nation-wide population-based prospective cohort study in Norway. Our main outcome measures were the period prevalence of single-occurring or different combinations of complaints based on medical records: (1) Pulmonary (dyspnea and/or cough), (2) Neurological (concentration problems, memory loss), and/or (3) General complaints (fatigue). In persons testing positive (n = 75 979), 64 (95% confidence interval: 54 to 73) and 122 (111 to 113) more persons per 10 000 persons had pulmonary complaints 5-6 months after the test compared to 10 000 persons testing negative (n = 1 167 582) or untested (n = 1 084 578), respectively. The corresponding difference in prevalence of general complaints (fatigue) was 181 (168 to 195) and 224 (211 to 238) per 10 000, and of neurological complaints 5 (2 to 8) and 9 (6-13) per 10 000. Overlap between complaints was rare. Long COVID complaints were only slightly more prevalent in persons with than without confirmed COVID-19. Still, long COVID may pose a substantial burden to healthcare systems in the future given the lasting high incidence of symptomatic COVID-19 in both vaccinated and unvaccinated individuals.", "doi": "10.1038/s41598-023-32636-y", "pmid": "37055494", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC10100609"}, {"db": "pii", "key": "10.1038/s41598-023-32636-y"}], "notes": [], "created": "2023-04-20T17:26:10.891Z", "modified": "2023-04-20T17:26:10.896Z"}, {"entity": "publication", "iuid": "8d443acded49416b84400eec2820cb88", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d443acded49416b84400eec2820cb88.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d443acded49416b84400eec2820cb88"}}, "title": "Impact assessment of immunization and the COVID-19 pandemic on varicella across Europe using digital epidemiology methods: A descriptive study.", "authors": [{"family": "Sabale", "given": "Ugne", "initials": "U", "orcid": "0000-0003-1874-8730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8386a4d80734ee5bb684d2405977d75.json"}}, {"family": "Jarmale", "given": "Ligita", "initials": "L"}, {"family": "Murtagh", "given": "Janice", "initials": "J"}, {"family": "Pawaskar", "given": "Manjiri", "initials": "M"}, {"family": "Bencina", "given": "Goran", "initials": "G", "orcid": "0000-0001-6293-8211", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b5e3d769bcd43b9a8a76b70188ad470.json"}}], "type": "journal article", "published": "2023-04-12", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "18", "issue": "4", "pages": "e0283465", "issn-l": "1932-6203"}, "abstract": "Varicella is usually a mild disease in children but may be life-threatening, especially in adolescents and adults. Infection control measures implemented during the Coronavirus Disease 2019 (COVID-19) pandemic may have suppressed varicella transmission, potentially creating an 'immunity debt', particularly in countries without universal varicella vaccination.\n\nTo assess trends in Google search engine queries for varicella keywords as a proxy for varicella infection rates and to evaluate the effect of universal varicella vaccination on these trends. A further objective was to assess the impact of the COVID-19 pandemic on varicella keyword search query trends in countries with and without universal varicella vaccination.\n\nThis study used the keyword research tool, Google Trends, to evaluate trends in time series of the relative search query popularity of language-specific varicella keywords in 28 European countries from January 2015 through December 2021. The Google Ads Keyword Planner tool was used to evaluate absolute search volumes from March 2018 through December 2021.\n\nThe relative search query popularity of varicella keywords displayed marked seasonal variation. In all 28 countries, the relative search query popularity of varicella keywords declined after the start of the COVID-19 pandemic (March 2020), compared with pre-pandemic levels (range, -18% to -70%). From April 2020 to July 2021, a period of intense COVID-19 transmission and infection control, absolute search volumes for varicella keywords were lower than pre-pandemic levels but rebounded after July 2021, when infection control measures were relaxed.\n\nThis evaluation of search query trends demonstrated that search query data could be used as a proxy for trends in varicella infection rates and revealed that transmission of varicella may have been suppressed during the COVID-19 pandemic. Consideration should be given to using search query data to better understand the burden of varicella, particularly in countries where surveillance systems are inadequate.", "doi": "10.1371/journal.pone.0283465", "pmid": "37043422", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10096188"}, {"db": "pii", "key": "PONE-D-22-28976"}], "notes": [], "created": "2023-04-20T17:26:54.270Z", "modified": "2023-04-20T17:27:04.009Z"}, {"entity": "publication", "iuid": "781d1e6d1305446697e712e4bce7cb83", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/781d1e6d1305446697e712e4bce7cb83.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/781d1e6d1305446697e712e4bce7cb83"}}, "title": "Subclass-switched anti-spike IgG3 oligoclonal cocktails strongly enhance Fc-mediated opsonization.", "authors": [{"family": "Izadi", "given": "Arman", "initials": "A", "orcid": "0000-0002-0262-1017", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d36b0ac6385471b917f3be9131d4d57.json"}}, {"family": "Hailu", "given": "Arsema", "initials": "A"}, {"family": "Godzwon", "given": "Magdalena", "initials": "M", "orcid": "0000-0002-9745-1160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/386a6fc861e64386bf32de44d013277f.json"}}, {"family": "Wrighton", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-3378-7925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/740aa0208cea4c27a4297849cec4f9f9.json"}}, {"family": "Olofsson", "given": "Berit", "initials": "B", "orcid": "0009-0009-0602-2183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8cdf27b432648f3957550c8b99bc5b2.json"}}, {"family": "Schmidt", "given": "Tobias", "initials": "T"}, {"family": "S\u00f6derlund-Strand", "given": "Anna", "initials": "A", "orcid": "0009-0001-8886-4385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32d681c0fc724de18f0839cbc41f4f34.json"}}, {"family": "Elder", "given": "Elizabeth", "initials": "E", "orcid": "0000-0003-1615-2642", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f34193310b964fe4b87f65ca04193939.json"}}, {"family": "Appelberg", "given": "Sofia", "initials": "S", "orcid": "0000-0002-7381-3606", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a3e2ab8513742af91714b79b472734a.json"}}, {"family": "Valsj\u00f6", "given": "Maria", "initials": "M"}, {"family": "Larsson", "given": "Olivia", "initials": "O"}, {"family": "Wendel-Hansen", "given": "Vidar", "initials": "V", "orcid": "0009-0002-3179-1565", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e54287872af3447d9d35d0dca01f65b6.json"}}, {"family": "Ohlin", "given": "Mats", "initials": "M", "orcid": "0000-0002-5105-1938", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/def6c0678dfd48ea9a1255a8a00e7ebc.json"}}, {"family": "Bahnan", "given": "Wael", "initials": "W"}, {"family": "Nordenfelt", "given": "Pontus", "initials": "P", "orcid": "0000-0002-9481-9951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe1c1345d0bf4316bead223ad6c9f8a8.json"}}], "type": "journal article", "published": "2023-04-11", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "120", "issue": "15", "pages": "e2217590120", "issn-l": "0027-8424"}, "abstract": "Antibodies play a central role in the immune defense against SARS-CoV-2. Emerging evidence has shown that nonneutralizing antibodies are important for immune defense through Fc-mediated effector functions. Antibody subclass is known to affect downstream Fc function. However, whether the antibody subclass plays a role in anti-SARS-CoV-2 immunity remains unclear. Here, we subclass-switched eight human IgG1 anti-spike monoclonal antibodies (mAbs) to the IgG3 subclass by exchanging their constant domains. The IgG3 mAbs exhibited altered avidities to the spike protein and more potent Fc-mediated phagocytosis and complement activation than their IgG1 counterparts. Moreover, combining mAbs into oligoclonal cocktails led to enhanced Fc- and complement receptor-mediated phagocytosis, superior to even the most potent single IgG3 mAb when compared at equivalent concentrations. Finally, in an in vivo model, we show that opsonic mAbs of both subclasses can be protective against a SARS-CoV-2 infection, despite the antibodies being nonneutralizing. Our results suggest that opsonic IgG3 oligoclonal cocktails are a promising idea to explore for therapy against SARS-CoV-2, its emerging variants, and potentially other viruses.", "doi": "10.1073/pnas.2217590120", "pmid": "37011197", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-04-12T16:48:19.412Z", "modified": "2023-04-12T16:48:36.407Z"}, {"entity": "publication", "iuid": "7481bb67ff36401c896db17824f69322", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7481bb67ff36401c896db17824f69322.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7481bb67ff36401c896db17824f69322"}}, "title": "The impact of Covid-19 in patients with chronic myeloid leukemia-a nationwide population-based study.", "authors": [{"family": "Dahl\u00e9n", "given": "Torsten", "initials": "T", "orcid": "0000-0002-3856-7227", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69a3a4703c134438836a76bd0dec1c68.json"}}, {"family": "Flygt", "given": "Hjalmar", "initials": "H"}, {"family": "L\u00fcbking", "given": "Anna", "initials": "A"}, {"family": "Olsson-Str\u00f6mberg", "given": "Ulla", "initials": "U"}, {"family": "Wennstr\u00f6m", "given": "Lovisa", "initials": "L"}, {"family": "Dreimane", "given": "Arta", "initials": "A"}, {"family": "Sj\u00e4lander", "given": "Anders", "initials": "A", "orcid": "0000-0001-9422-1186", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/290cd473f57946678cf6a391cf58c120.json"}}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Li", "given": "Huiqi", "initials": "H", "orcid": "0000-0002-1127-0829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e3bd3ff6b4e4f448f9332081da1dc29.json"}}, {"family": "H\u00f6glund", "given": "Martin", "initials": "M"}, {"family": "Stenke", "given": "Leif", "initials": "L"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2023-04-10", "journal": {"title": "Leukemia", "issn": "1476-5551", "pages": "1-4", "issn-l": null}, "abstract": null, "doi": "10.1038/s41375-023-01893-1", "pmid": "37037908", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10088575"}, {"db": "pii", "key": "10.1038/s41375-023-01893-1"}], "notes": [], "created": "2023-04-17T14:42:01.368Z", "modified": "2023-04-20T17:29:07.885Z"}, {"entity": "publication", "iuid": "90572370bf5049dba72acc96b9bff5bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90572370bf5049dba72acc96b9bff5bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90572370bf5049dba72acc96b9bff5bd"}}, "title": "The febrile infant: Is it COVID-19 or a serious bacterial infection?", "authors": [{"family": "Ohlin", "given": "Andreas", "initials": "A", "orcid": "0000-0003-0531-6189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ba9ad0ed35f4cbc94aff40e614dbb03.json"}}], "type": "editorial", "published": "2023-04-10", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253"}, "abstract": null, "doi": "10.1111/apa.16783", "pmid": "37035897", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2023-04-20T17:29:19.414Z", "modified": "2023-04-20T17:29:19.451Z"}, {"entity": "publication", "iuid": "e33999b56fec47e29b9dbf27d95de814", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e33999b56fec47e29b9dbf27d95de814.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e33999b56fec47e29b9dbf27d95de814"}}, "title": "Family doctors' roles and perceptions on antibiotic consumption and antibiotic resistance in Romania: a qualitative study.", "authors": [{"family": "Ghiga", "given": "Ioana", "initials": "I"}, {"family": "Pitchforth", "given": "Emma", "initials": "E"}, {"family": "St\u00e5lsby Lundborg", "given": "Cecilia", "initials": "C"}, {"family": "Machowska", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2023-04-10", "journal": {"title": "BMC Prim Care", "issn": "2731-4553", "volume": "24", "issue": "1", "pages": "93", "issn-l": null}, "abstract": "Antimicrobial resistance (AMR) is a major global health issue, bringing significant health burden and costs to societies. Increased antibiotic consumption (ABC) is linked to AMR emergence. Some of the known drivers of ABC are antibiotics over-prescription by physicians and their misuse by patients. Family doctors are recognised as important stakeholders in the control of ABC as they prescribe antibiotics and are considered a reliable source of medical information by patients. Therefore, it is important to explore their perceptions, especially in Romania, which has the highest ABC among European Union Member States. Furthermore, there is no published research exploring Romanian family doctors' perceptions regarding this phenomenon.\n\nThis was a qualitative study with data collection via semi-structured interviews among 12 family doctors. Manifest and latent content analysis was used to gain an in-depth understanding of their perceptions. Findings were mapped onto the domains of the Behaviour Change Wheel to facilitate a theory driven systematization and analysis.\n\nTwo main subthemes emerged: i) factors affecting ABC and prescribing and ii) potential interventions to tackle ABC and antibiotic resistance. The factors were further grouped in those that related to the perceived behaviour of family doctors or patients as well as those that had to do with the various systems, local contexts and the COVID-19 pandemic. An overarching theme: 'family doctors in Romania see their role differently when it comes to antibiotic resistance and perceive the lack of patient education or awareness as one of the major drivers of ABC' was articulated. The main findings suggested that the perceived factors span across the capability, opportunity and motivational domains of the behaviour change wheel and could be addressed through a variety of interventions - some identified by the participants. Findings can also be viewed through cultural lenses which shed further light on the family doctor- patient dynamic when it comes to antibiotics use.\n\nPotential interventions to tackle identified factors emerged, revolving mostly on efforts to educate patients or the public. This exploratory research provides key perspectives and facilitates further research on potential interventions to successfully address AMR in Romania or similar settings.", "doi": "10.1186/s12875-023-02047-z", "pmid": "37038124", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10084585"}, {"db": "pii", "key": "10.1186/s12875-023-02047-z"}], "notes": [], "created": "2023-04-20T17:28:19.348Z", "modified": "2023-04-20T17:28:19.361Z"}, {"entity": "publication", "iuid": "ae8737f2cf2e43f4bde138652616bc8d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ae8737f2cf2e43f4bde138652616bc8d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ae8737f2cf2e43f4bde138652616bc8d"}}, "title": "How Older Persons and Health Care Professionals Co-designed a Medication Plan Prototype Remotely to Promote Patient Safety: Case Study.", "authors": [{"family": "Holmqvist", "given": "Malin", "initials": "M", "orcid": "0000-0003-3221-9800", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1ccb090de9941ef9c9198efe68ae74a.json"}}, {"family": "Ros", "given": "Axel", "initials": "A", "orcid": "0000-0001-6302-8068", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a05b39ead83344668c7baeb3e9b9dae6.json"}}, {"family": "Lindenfalk", "given": "Bertil", "initials": "B", "orcid": "0000-0003-0123-6392", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f070b0a31bfa4d14a84541618e813961.json"}}, {"family": "Thor", "given": "Johan", "initials": "J", "orcid": "0000-0003-1814-4478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a3b8c916bd0496b89cf7d42186d8832.json"}}, {"family": "Johansson", "given": "Linda", "initials": "L", "orcid": "0000-0001-7101-3165", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1af866dfcbe7406ab5785fee6fc740cf.json"}}], "type": "journal article", "published": "2023-04-07", "journal": {"title": "JMIR Aging", "issn": "2561-7605", "volume": "6", "pages": "e41950", "issn-l": null}, "abstract": "Harm from medications is a major patient safety challenge. Most adverse drug events arise when a medication is prescribed or reevaluated. Therefore, interventions in this area may improve patient safety. A medication plan, that is, a plan for continued treatment with medications, may support patient safety. Participation of patients in the design of health care products or services may improve patient safety. Co-design, as in the Double Diamond framework from the Design Council, England, can emphasize patient involvement. As the COVID-19 pandemic brought restrictions to face-to-face co-design approaches, interest in remote approaches increased. However, it is uncertain how best to perform remote co-design. Therefore, we explored a remote approach, which brought together older persons and health care professionals to co-design a medication plan prototype in the electronic health record, aiming to support patient safety.\n\nThis study aimed to describe how remote co-design was applied to create a medication plan prototype and to explore participants' experiences with this approach.\n\nWithin a case study design, we explored the experiences of a remote co-design initiative with 14 participants in a regional health care system in southern Sweden. Using descriptive statistics, quantitative data from questionnaires and web-based workshop timestamps were analyzed. A thematic analysis of the qualitative data gathered from workshops, interviews, and free-text responses to the survey questions was performed. Qualitative and quantitative data were compared side by side in the discussion.\n\nThe analysis of the questionnaires revealed that the participants rated the experiences of the co-design initiative very high. In addition, the balance between how much involved persons expressed their wishes and were listened to was considered very good. Marked timestamps from audio recordings showed that the workshops proceeded according to the plan. The thematic analysis yielded the following main themes: Everyone's perspective matters, Learning by sharing, and Mastering a digital space. The themes encompassed what helped to establish a permissive environment that allowed the participants to be involved and share viewpoints. There was a dynamic process of learning and understanding, realizing that despite different backgrounds, there was consensus about the requirements for a medication plan. The remote co-design process seemed appealing, by balancing opportunities and challenges and building an inviting, creative, and tolerant environment.\n\nParticipants experienced that the remote co-design initiative was inclusive of their perspectives and facilitated learning by sharing experiences. The Double Diamond framework was applicable in a digital context and supported the co-design process of the medication plan prototype. Remote co-design is still novel, but with attentiveness to power relations between all involved, this approach may increase opportunities for older persons and health care professionals to collaboratively design products or services that can improve patient safety.", "doi": "10.2196/41950", "pmid": "37027205", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "v6i1e41950"}], "notes": [], "created": "2023-04-20T17:30:17.565Z", "modified": "2023-04-20T17:30:17.755Z"}, {"entity": "publication", "iuid": "972c0def9aee4a7f9c9497925521940d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/972c0def9aee4a7f9c9497925521940d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/972c0def9aee4a7f9c9497925521940d"}}, "title": "Exploring workplace violence on surgical wards in Sweden: a cross-sectional study.", "authors": [{"family": "Jakobsson", "given": "Jenny", "initials": "J"}, {"family": "\u00d6rmon", "given": "Karin", "initials": "K"}, {"family": "Axelsson", "given": "Malin", "initials": "M"}, {"family": "Berthelsen", "given": "Hanne", "initials": "H"}], "type": "journal article", "published": "2023-04-07", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "volume": "22", "issue": "1", "pages": "106", "issn-l": null}, "abstract": "Workplace violence is a global threat to healthcare professionals' occupational health and safety and the situation has worsened during the COVID-19 pandemic. This study aimed to explore workplace violence directed against assistant and registered nurses working on surgical wards in Sweden.\n\nThis cross-sectional study was conducted in April 2022. Using a convenience sampling procedure, 198 assistant and registered nurses responded to an online questionnaire developed for this specific study. The questionnaire comprised 52 items and included, among other items, subscales from validated and previously used instruments. Data analysis included descriptive statistics, the chi-square test, and independent-samples t-test.\n\nThe most frequently reported type of workplace violence was humiliation (28.8%), followed by physical violence (24.2%), threats (17.7%), and unwanted sexual attention (12.1%). Patients and patients' visitors were reported as the main perpetrators of all kinds of exposure. Additionally, one third of the respondents had experienced humiliation from colleagues. Both threats and humiliation showed negative associations with work motivation and health (p < 0.05). Respondents classified as working in a high- or moderate-risk environment were more frequently exposed to threats (p = 0.025) and humiliation (p = 0.003). Meanwhile, half of the respondents were unaware of any action plans or training regarding workplace violence. However, of those who indicated that they had been exposed to workplace violence, the majority had received quite a lot or a lot of support, mainly from colleagues (range 70.8-80.8%).\n\nDespite a high prevalence of workplace violence, and especially of humiliating acts, there appeared to be low preparedness within the hospital organizations to prevent and/or handle such incidents. To improve these conditions, hospital organizations should place more emphasis on preventive measures as part of their systematic work environment management. To help inform such initiatives, it is suggested that future research should focus on the identification of suitable measures regarding different types of incidents, perpetrators, and settings.", "doi": "10.1186/s12912-023-01275-z", "pmid": "37029387", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10079490"}, {"db": "pii", "key": "10.1186/s12912-023-01275-z"}], "notes": [], "created": "2023-04-20T17:30:03.709Z", "modified": "2023-04-20T17:30:03.725Z"}, {"entity": "publication", "iuid": "654faa31ec7f4ec68d7c29f27107de55", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/654faa31ec7f4ec68d7c29f27107de55.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/654faa31ec7f4ec68d7c29f27107de55"}}, "title": "Study protocol of a phase 2, randomised, placebo-controlled, double-blind, adaptive, parallel group clinical study to evaluate the efficacy and safety of recombinant alpha-1-microglobulin in subjects at high risk for acute kidney injury following open-chest cardiac surgery (AKITA trial).", "authors": [{"family": "Mazer", "given": "C David", "initials": "CD", "orcid": "0000-0003-2566-4308", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4562eb6f8cb94b42ba42985a8e534bc4.json"}}, {"family": "Siadati-Fini", "given": "Niloufar", "initials": "N"}, {"family": "Boehm", "given": "Johannes", "initials": "J"}, {"family": "Wirth", "given": "Felix", "initials": "F"}, {"family": "Myjavec", "given": "Andrej", "initials": "A"}, {"family": "Brown", "given": "Craig D", "initials": "CD"}, {"family": "Koyner", "given": "Jay L", "initials": "JL"}, {"family": "Boening", "given": "Andreas", "initials": "A"}, {"family": "Engelman", "given": "Daniel T", "initials": "DT"}, {"family": "Larsson", "given": "Tobias E", "initials": "TE"}, {"family": "Renfurm", "given": "Ronny", "initials": "R"}, {"family": "de Varennes", "given": "Benoit", "initials": "B"}, {"family": "Noiseux", "given": "Nicolas", "initials": "N"}, {"family": "Thielmann", "given": "Matthias", "initials": "M"}, {"family": "Lamy", "given": "Andre", "initials": "A"}, {"family": "Laflamme", "given": "Maxime", "initials": "M"}, {"family": "von Groote", "given": "Thilo", "initials": "T", "orcid": "0000-0002-5287-1137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c09b4126b4124412b1f727eded281171.json"}}, {"family": "Ronco", "given": "Claudio", "initials": "C"}, {"family": "Zarbock", "given": "Alexander", "initials": "A", "orcid": "0000-0002-2124-1714", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6171146769d4287976ae737bbe755cd.json"}}], "type": "clinical trial protocol", "published": "2023-04-06", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "13", "issue": "4", "pages": "e068363", "issn-l": "2044-6055"}, "abstract": "Acute kidney injury (AKI) is a common complication after cardiac surgery (CS) and is associated with adverse short-term and long-term outcomes. Alpha-1-microglobulin (A1M) is a circulating glycoprotein with antioxidant, heme binding and mitochondrial-protective mechanisms. RMC-035 is a modified, more soluble, variant of A1M and has been proposed as a novel targeted therapeutic protein to prevent CS-associated AKI (CS-AKI). RMC-035 was considered safe and generally well tolerated when evaluated in four clinical phase 1 studies.\n\nThis is a phase 2, randomised, double-blind, adaptive design, parallel group clinical study that evaluates RMC-035 compared with placebo in approximately 268 cardiac surgical patients at high risk for CS-AKI. RMC-035 is administered as an intravenous infusion. In total, five doses will be given. Dosing is based on presurgery estimated glomerular filtration rate (eGFR), and will be either 1.3 or 0.65 mg/kg.The primary study objective is to evaluate whether RMC-035 reduces the incidence of postoperative AKI, and key secondary objectives are to evaluate whether RMC-035 improves postoperative renal function compared with placebo. A blinded interim analysis with potential sample size reassessment is planned once 134 randomised subjects have completed dosing. An independent data monitoring committee will evaluate safety and efficacy data at prespecified intervals throughout the trial. The study is a global multicentre study at approximately 30 sites.\n\nThe trial was approved by the joint ethics committee of the physician chamber Westfalen-Lippe and the University of M\u00fcnster (code '2021-778 f-A') and subsequently approved by the responsible ethics committees/relevant institutional review boards for the participating sites. The study is conducted in accordance with Good Clinical Practice, the Declaration of Helsinki and other applicable regulations. Results of this study will be published in a peer-reviewed scientific journal.\n\nNCT05126303.", "doi": "10.1136/bmjopen-2022-068363", "pmid": "37024249", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2022-068363"}, {"db": "ClinicalTrials.gov", "key": "NCT05126303"}], "notes": [], "created": "2023-04-12T16:47:54.133Z", "modified": "2023-04-12T16:47:54.232Z"}, {"entity": "publication", "iuid": "cedb318e6dfe4c94be75c5c45506300b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cedb318e6dfe4c94be75c5c45506300b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cedb318e6dfe4c94be75c5c45506300b"}}, "title": "Epitopes displayed in a cyclic peptide scaffold bind SARS-CoV-2 antibodies.", "authors": [{"family": "Eriksson", "given": "Camilla", "initials": "C"}, {"family": "Gunasekera", "given": "Sunithi", "initials": "S"}, {"family": "Muhammad", "given": "Taj", "initials": "T"}, {"family": "Zhang", "given": "Mingshu", "initials": "M"}, {"family": "Laur\u00e9n", "given": "Ida", "initials": "I"}, {"family": "Mangsbo", "given": "Sara M", "initials": "SM"}, {"family": "Lord", "given": "Martin", "initials": "M"}, {"family": "G\u00f6ransson", "given": "Ulf", "initials": "U"}], "type": "journal article", "published": "2023-04-06", "journal": {"title": "Chembiochem", "issn": "1439-7633", "issn-l": null, "volume": null, "issue": null, "pages": "e202300103"}, "abstract": "The SARS-CoV-2 virus that causes COVID-19 is a global health issue. The spread of the virus has resulted in more than six million deaths to date. The emergence of new viral strains highlights the importance of continuous surveillance of the SARS-CoV-2 virus, using timely and accurate diagnostic tools. Here, we used stable cyclic peptide scaffolds to present antigenic sequences derived from spike protein, reactive to SARS-CoV-2 antibodies. Using peptide sequences from different domains of SARS-CoV-2 spike protein, we grafted epitopes on the peptide scaffold sunflower trypsin inhibitor 1 (SFTI-1). These scaffold peptides were then used to develop a SARS-CoV-2 ELISA to detect SARS-CoV-2 antibodies in serum. We show that displaying epitopes in the scaffold improves reactivity overall. One of the scaffold peptides (S2_1146-1161_c) has reactivity equal to commercial assays, and shows diagnostic potential.", "doi": "10.1002/cbic.202300103", "pmid": "37021633", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-12T16:47:12.592Z", "modified": "2023-04-20T17:31:28.239Z"}, {"entity": "publication", "iuid": "fedaad814d10430d9d7328bf62b46739", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fedaad814d10430d9d7328bf62b46739.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fedaad814d10430d9d7328bf62b46739"}}, "title": "Electrochemical lateral-flow device for rapid COVID-19 antigen-diagnostic testing.", "authors": [{"family": "Deenin", "given": "Wanwisa", "initials": "W"}, {"family": "Yakoh", "given": "Abdulhadee", "initials": "A"}, {"family": "Pimpitak", "given": "Umaporn", "initials": "U"}, {"family": "Pasomsub", "given": "Ekawat", "initials": "E"}, {"family": "Rengpipat", "given": "Sirirat", "initials": "S"}, {"family": "Crespo", "given": "Gast\u00f3n A", "initials": "GA"}, {"family": "Chaiyo", "given": "Sudkate", "initials": "S"}], "type": "journal article", "published": "2023-04-06", "journal": {"title": "Bioelectrochemistry", "issn": "1878-562X", "volume": "152", "pages": "108438", "issn-l": null}, "abstract": "Antigen test kits (ATK) are extensively utilized for screening and diagnosing COVID-19 because they are easy to operate. However, ATKs exhibit poor sensitivity and cannot detect low concentrations of SARS-CoV-2. Herein, we present a new, highly sensitive, and selective device obtained by combining the principle of ATKs with electrochemical detection for COVID-19 diagnosis, which can be quantitatively assessed using a smartphone. An electrochemical test strip (E-test strip) was constructed by attaching a screen-printed electrode inside a lateral-flow device to exploit the remarkable binding affinity of SARS-CoV-2 antigen to ACE2. The ferrocene carboxylic acid attached to SARS-CoV-2 antibody acts as an electroactive species when it binds to SARS-CoV-2 antigen in the sample before it flows continuously to the ACE2-immobilization region on the electrode. Electrochemical-assay signal intensity on smartphones increased proportionally to the concentration of SARS-CoV-2 antigen (LOD = 2.98 pg/mL, under 12 min). Additionally, the application of the single-step E-test strip for COVID-19 screening was demonstrated using nasopharyngeal samples, and the results were consistent with those obtained using the gold standard (RT-PCR). Therefore, the sensor demonstrated excellent performance in assessing and screening COVID-19, and it can be used professionally to accurately verify diagnostic data while remaining rapid, simple, and inexpensive.", "doi": "10.1016/j.bioelechem.2023.108438", "pmid": "37054603", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10077809"}, {"db": "pii", "key": "S1567-5394(23)00075-0"}], "notes": [], "created": "2023-04-20T17:26:29.972Z", "modified": "2023-04-20T17:26:29.999Z"}, {"entity": "publication", "iuid": "4771f29f0a704723929281738b0b3549", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4771f29f0a704723929281738b0b3549.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4771f29f0a704723929281738b0b3549"}}, "title": "Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.", "authors": [{"family": "Matuozzo", "given": "Daniela", "initials": "D"}, {"family": "Talouarn", "given": "Estelle", "initials": "E"}, {"family": "Marchal", "given": "Astrid", "initials": "A"}, {"family": "Zhang", "given": "Peng", "initials": "P"}, {"family": "Manry", "given": "Jeremy", "initials": "J"}, {"family": "Seeleuthner", "given": "Yoann", "initials": "Y"}, {"family": "Zhang", "given": "Yu", "initials": "Y"}, {"family": "Bolze", "given": "Alexandre", "initials": "A"}, {"family": "Chaldebas", "given": "Matthieu", "initials": "M"}, {"family": "Milisavljevic", "given": "Baptiste", "initials": "B"}, {"family": "Gervais", "given": "Adrian", "initials": "A"}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Asano", "given": "Takaki", "initials": "T"}, {"family": "Bizien", "given": "Lucy", "initials": "L"}, {"family": "Barzaghi", "given": "Federica", "initials": "F"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Abou Tayoun", "given": "Ahmad", "initials": "A"}, {"family": "Aiuti", "given": "Alessandro", "initials": "A"}, {"family": "Alavi Darazam", "given": "Ilad", "initials": "I"}, {"family": "Allende", "given": "Luis M", "initials": "LM"}, {"family": "Alonso-Arias", "given": "Rebeca", "initials": "R"}, {"family": "Arias", "given": "Andr\u00e9s Augusto", "initials": "AA"}, {"family": "Aytekin", "given": "Gokhan", "initials": "G"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Bondesan", "given": "Simone", "initials": "S"}, {"family": "Bryceson", "given": "Yenan T", "initials": "YT"}, {"family": "Bustos", "given": "Ingrid G", "initials": "IG"}, {"family": "Cabrera-Marante", "given": "Oscar", "initials": "O"}, {"family": "Carcel", "given": "Sheila", "initials": "S"}, {"family": "Carrera", "given": "Paola", "initials": "P"}, {"family": "Casari", "given": "Giorgio", "initials": "G"}, {"family": "Cha\u00efbi", "given": "Khalil", "initials": "K"}, {"family": "Colobran", "given": "Roger", "initials": "R"}, {"family": "Condino-Neto", "given": "Antonio", "initials": "A"}, {"family": "Covill", "given": "Laura E", "initials": "LE"}, {"family": "Delmonte", "given": "Ottavia M", "initials": "OM"}, {"family": "El Zein", "given": "Loubna", "initials": "L"}, {"family": "Flores", "given": "Carlos", "initials": "C"}, {"family": "Gregersen", "given": "Peter K", "initials": "PK"}, {"family": "Gut", "given": "Marta", "initials": "M"}, {"family": "Haerynck", "given": "Filomeen", "initials": "F"}, {"family": "Halwani", "given": "Rabih", "initials": "R"}, {"family": "Hancerli", "given": "Selda", "initials": "S"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Hatipo\u011flu", "given": "Nevin", "initials": "N"}, {"family": "Karbuz", "given": "Adem", "initials": "A"}, {"family": "Keles", "given": "Sevgi", "initials": "S"}, {"family": "Kyheng", "given": "Christ\u00e8le", "initials": "C"}, {"family": "Leon-Lopez", "given": "Rafael", "initials": "R"}, {"family": "Franco", "given": "Jose Luis", "initials": "JL"}, {"family": "Mansouri", "given": "Davood", "initials": "D"}, {"family": "Martinez-Picado", "given": "Javier", "initials": "J"}, {"family": "Metin Akcan", "given": "Ozge", "initials": "O"}, {"family": "Migeotte", "given": "Isabelle", "initials": "I"}, {"family": "Morange", "given": "Pierre-Emmanuel", "initials": "PE"}, {"family": "Morelle", "given": "Guillaume", "initials": "G"}, {"family": "Martin-Nalda", "given": "Andrea", "initials": "A"}, {"family": "Novelli", "given": "Giuseppe", "initials": "G"}, {"family": "Novelli", "given": "Antonio", "initials": "A"}, {"family": "Ozcelik", "given": "Tayfun", "initials": "T"}, {"family": "Palabiyik", "given": "Figen", "initials": "F"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}, {"family": "de Diego", "given": "Rebeca P\u00e9rez", "initials": "RP"}, {"family": "Planas-Serra", "given": "Laura", "initials": "L"}, {"family": "Pleguezuelo", "given": "Daniel E", "initials": "DE"}, {"family": "Prando", "given": "Carolina", "initials": "C"}, {"family": "Pujol", "given": "Aurora", "initials": "A"}, {"family": "Reyes", "given": "Luis Felipe", "initials": "LF"}, {"family": "Rivi\u00e8re", "given": "Jacques G", "initials": "JG"}, {"family": "Rodriguez-Gallego", "given": "Carlos", "initials": "C"}, {"family": "Rojas", "given": "Julian", "initials": "J"}, {"family": "Rovere-Querini", "given": "Patrizia", "initials": "P"}, {"family": "Schl\u00fcter", "given": "Agatha", "initials": "A"}, {"family": "Shahrooei", "given": "Mohammad", "initials": "M"}, {"family": "Sobh", "given": "Ali", "initials": "A"}, {"family": "Soler-Palacin", "given": "Pere", "initials": "P"}, {"family": "Tandjaoui-Lambiotte", "given": "Yacine", "initials": "Y"}, {"family": "Tipu", "given": "Imran", "initials": "I"}, {"family": "Tresoldi", "given": "Cristina", "initials": "C"}, {"family": "Troya", "given": "Jesus", "initials": "J"}, {"family": "van de Beek", "given": "Diederik", "initials": "D"}, {"family": "Zatz", "given": "Mayana", "initials": "M"}, {"family": "Zawadzki", "given": "Pawel", "initials": "P"}, {"family": "Al-Muhsen", "given": "Saleh Zaid", "initials": "SZ"}, {"family": "Alosaimi", "given": "Mohammed Faraj", "initials": "MF"}, {"family": "Alsohime", "given": "Fahad M", "initials": "FM"}, {"family": "Baris-Feldman", "given": "Hagit", "initials": "H"}, {"family": "Butte", "given": "Manish J", "initials": "MJ"}, {"family": "Constantinescu", "given": "Stefan N", "initials": "SN"}, {"family": "Cooper", "given": "Megan A", "initials": "MA"}, {"family": "Dalgard", "given": "Clifton L", "initials": "CL"}, {"family": "Fellay", "given": "Jacques", "initials": "J"}, {"family": "Heath", "given": "James R", "initials": "JR"}, {"family": "Lau", "given": "Yu-Lung", "initials": "YL"}, {"family": "Lifton", "given": "Richard P", "initials": "RP"}, {"family": "Maniatis", "given": "Tom", "initials": "T"}, {"family": "Mogensen", "given": "Trine H", "initials": "TH"}, {"family": "von Bernuth", "given": "Horst", "initials": "H"}, {"family": "Lermine", "given": "Alban", "initials": "A"}, {"family": "Vidaud", "given": "Michel", "initials": "M"}, {"family": "Boland", "given": "Anne", "initials": "A"}, {"family": "Deleuze", "given": "Jean-Fran\u00e7ois", "initials": "JF"}, {"family": "Nussbaum", "given": "Robert", "initials": "R"}, {"family": "Kahn-Kirby", "given": "Amanda", "initials": "A"}, {"family": "Mentre", "given": "France", "initials": "F"}, {"family": "Tubiana", "given": "Sarah", "initials": "S"}, {"family": "Gorochov", "given": "Guy", "initials": "G"}, {"family": "Tubach", "given": "Florence", "initials": "F"}, {"family": "Hausfater", "given": "Pierre", "initials": "P"}, {"family": "COVID Human Genetic Effort", "given": "", "initials": ""}, {"family": "COVIDeF Study Group", "given": "", "initials": ""}, {"family": "French COVID Cohort Study Group", "given": "", "initials": ""}, {"family": "CoV-Contact Cohort", "given": "", "initials": ""}, {"family": "COVID-STORM Clinicians", "given": "", "initials": ""}, {"family": "COVID Clinicians", "given": "", "initials": ""}, {"family": "Orchestra Working Group", "given": "", "initials": ""}, {"family": "Amsterdam UMC Covid-19 Biobank", "given": "", "initials": ""}, {"family": "NIAID-USUHS COVID Study Group", "given": "", "initials": ""}, {"family": "Meyts", "given": "Isabelle", "initials": "I"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Puel", "given": "Anne", "initials": "A"}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD"}, {"family": "Boisson-Dupuis", "given": "Stephanie", "initials": "S"}, {"family": "Su", "given": "Helen C", "initials": "HC"}, {"family": "Boisson", "given": "Bertrand", "initials": "B"}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL"}, {"family": "Zhang", "given": "Qian", "initials": "Q"}, {"family": "Abel", "given": "Laurent", "initials": "L"}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5369fe152ac94b5a81d4f913d85940a7.json"}}], "type": "journal article", "published": "2023-04-05", "journal": {"title": "Genome Med", "issn": "1756-994X", "issn-l": null, "volume": "15", "issue": "1", "pages": "22"}, "abstract": "We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases.\n\nWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.\n\nNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P = 1.1 \u00d7 10-4) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3-8.2], P = 2.1 \u00d7 10-4). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1-2635.4], P = 3.4 \u00d7 10-3), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3-8.4], P = 7.7 \u00d7 10-8). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 \u00d7 10-5).\n\nRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.", "doi": "10.1186/s13073-023-01173-8", "pmid": "37020259", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10074346"}, {"db": "pii", "key": "10.1186/s13073-023-01173-8"}, {"db": "ClinicalTrials.gov", "key": "NCT04262921"}, {"db": "ClinicalTrials.gov", "key": "NCT04259892"}, {"db": "ClinicalTrials.gov", "key": "NCT04352348"}], "notes": [], "created": "2023-04-12T16:45:00.367Z", "modified": "2023-06-19T15:33:16.774Z"}, {"entity": "publication", "iuid": "ebd0517b643c4bd296f4066e7bd2a421", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ebd0517b643c4bd296f4066e7bd2a421.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ebd0517b643c4bd296f4066e7bd2a421"}}, "title": "Progress in vaccine development for infectious diseases-a Keystone Symposia report.", "authors": [{"family": "Cable", "given": "Jennifer", "initials": "J"}, {"family": "Graham", "given": "Barney S", "initials": "BS"}, {"family": "Koup", "given": "Richard A", "initials": "RA"}, {"family": "Seder", "given": "Robert A", "initials": "RA"}, {"family": "Karik\u00f3", "given": "Katalin", "initials": "K"}, {"family": "Pardi", "given": "Norbert", "initials": "N"}, {"family": "Barouch", "given": "Dan H", "initials": "DH"}, {"family": "Sharma", "given": "Bhawna", "initials": "B"}, {"family": "Rauch", "given": "Susanne", "initials": "S"}, {"family": "Nachbagauer", "given": "Raffael", "initials": "R"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Schotsaert", "given": "Michael", "initials": "M"}, {"family": "Ellebedy", "given": "Ali H", "initials": "AH"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "Irvine", "given": "Darrell J", "initials": "DJ"}, {"family": "Pilkington", "given": "Emily", "initials": "E"}, {"family": "Tahtinen", "given": "Siri", "initials": "S"}, {"family": "Thompson", "given": "Elizabeth A", "initials": "EA"}, {"family": "Feraoun", "given": "Yanis", "initials": "Y"}, {"family": "King", "given": "Neil P", "initials": "NP"}, {"family": "Saunders", "given": "Kevin", "initials": "K"}, {"family": "Alter", "given": "Galit", "initials": "G"}, {"family": "Moin", "given": "Syed M", "initials": "SM"}, {"family": "Sliepen", "given": "Kwinten", "initials": "K"}, {"family": "Hedestam", "given": "Gunilla B Karlsson", "initials": "GBK"}, {"family": "Wardemann", "given": "Hedda", "initials": "H"}, {"family": "Pulendran", "given": "Bali", "initials": "B"}, {"family": "Doria-Rose", "given": "Nicole A", "initials": "NA"}, {"family": "He", "given": "Wan-Ting", "initials": "WT"}, {"family": "Juno", "given": "Jennifer A", "initials": "JA"}, {"family": "Ataca", "given": "Sila", "initials": "S"}, {"family": "Wheatley", "given": "Adam K", "initials": "AK"}, {"family": "McLellan", "given": "Jason S", "initials": "JS"}, {"family": "Walker", "given": "Laura M", "initials": "LM"}, {"family": "Lederhofer", "given": "Julia", "initials": "J"}, {"family": "Lindesmith", "given": "Lisa C", "initials": "LC"}, {"family": "Wille", "given": "Holger", "initials": "H"}, {"family": "Hotez", "given": "Peter J", "initials": "PJ"}, {"family": "Bekker", "given": "Linda-Gail", "initials": "LG"}], "type": "journal article", "published": "2023-04-05", "journal": {"title": "Ann N Y Acad Sci", "issn": "1749-6632", "issn-l": null}, "abstract": "The COVID-19 pandemic has taught us many things, among the most important of which is that vaccines are one of the cornerstones of public health that help make modern longevity possible. While several different vaccines have been successful at stemming the morbidity and mortality associated with various infectious diseases, many pathogens/diseases remain recalcitrant to the development of effective vaccination. Recent advances in vaccine technology, immunology, structural biology, and other fields may yet yield insight that will address these diseases; they may also help improve societies' preparedness for future pandemics. On June 1-4, 2022, experts in vaccinology from academia, industry, and government convened for the Keystone symposium \"Progress in Vaccine Development for Infectious Diseases\" to discuss state-of-the-art technologies, recent advancements in understanding vaccine-mediated immunity, and new aspects of antigen design to aid vaccine effectiveness.", "doi": "10.1111/nyas.14975", "pmid": "37020354", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-04-12T16:57:16.013Z", "modified": "2023-04-12T16:57:16.028Z"}, {"entity": "publication", "iuid": "e9de182c54464427a9bcf42df7f187b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e9de182c54464427a9bcf42df7f187b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e9de182c54464427a9bcf42df7f187b0"}}, "title": "The impact of immunomodulating treatment on the immunogenicity of COVID-19 vaccines in patients with immune-mediated inflammatory rheumatic diseases compared to healthy controls. A Swedish nationwide study (COVID19-REUMA).", "authors": [{"family": "Frodlund", "given": "Martina", "initials": "M"}, {"family": "Nived", "given": "Per", "initials": "P"}, {"family": "Chatzidionysiou", "given": "Aikaterini", "initials": "A"}, {"family": "S\u00f6dergren", "given": "Anna", "initials": "A"}, {"family": "Klingberg", "given": "Eva", "initials": "E"}, {"family": "Bengtsson", "given": "Anders", "initials": "A"}, {"family": "Hansson", "given": "Monika", "initials": "M"}, {"family": "Olsson", "given": "Sophie", "initials": "S"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Klareskog", "given": "Lars", "initials": "L"}, {"family": "Kapetanovic", "given": "Meliha C", "initials": "MC"}], "type": "journal article", "published": "2023-04-04", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null}, "abstract": "To elucidate antibody responses after the second and third dose of COVID-19 vaccine in patients with inflammatory rheumatic diseases (IRD) treated with biologic/targeted disease modifying anti-rheumatic drugs (b/ts DMARDs).\n\nAntibody levels to antigens representing spike full length protein and spike S1 were measured before vaccination, 2-12 weeks after the second dose, before and after the third dose using multiplex bead-based serology assay. Positive antibody response was defined as antibody levels over cut off (seropositivity) in seronegative individuals or \u2265 4-fold increase in antibodies in individuals seropositive for both spike proteins.\n\nPatients (n = 414) receiving b/ts DMARDs (283 had arthritis, 75 systemic vasculitis and 56 other autoimmune diseases) and controls (n = 61) from five Swedish regions participated. Treatments groups were: rituximab (n = 145); abatacept (n = 22); Interleukin 6 receptor inhibitors [IL6i (n = 79)]; JAnus Kinase Inhibitors [JAKi (n = 58)], Tumour Necrosis Factor inhibitor [TNFi (n = 68)] and Interleukin12/23/17 inhibitors [IL12/23/17i (n = 42)]. Percentage of patients with positive antibody response after two doses was significantly lower in rituximab (33,8%) and abatacept (40,9%) (p < 0,001) but not in IL12/23/17i, TNFi or JAKi groups compared to controls (80,3%). Higher age, rituximab treatment and shorter time between last rituximab course and vaccination predicted impaired antibody response. Antibody levels collected 21-40 weeks after second dose decreased significantly (IL6i: p = 0,02; other groups: p < 0,001) compared to levels at 2-12 week but most participants remained seropositive. Proportion of patients with positive antibody response increased after third dose but was still significantly lower in rituximab (p < 0,001).\n\nOlder individuals and patients on maintenance rituximab have an impaired response after two doses of COVID-19 vaccine which improves if the time between last rituximab course and vaccination extends and also after an additional vaccine dose. Rituximab patients should be prioritized for booster vaccine doses. TNFi, JAKi and IL12/23/17i does not diminished humoral response to primary and an additional vaccination.", "doi": "10.1016/j.vaccine.2023.03.065", "pmid": "37076360", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(23)00372-9"}], "notes": [], "created": "2023-04-20T17:19:58.707Z", "modified": "2023-04-20T17:19:58.711Z"}, {"entity": "publication", "iuid": "cfbc238647cc44adbd0dec991239d3af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfbc238647cc44adbd0dec991239d3af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfbc238647cc44adbd0dec991239d3af"}}, "title": "Risk of venous thromboembolism in patients with COVID-19 during 2020; a retrospective cross-sectional study in a Swedish health care system.", "authors": [{"family": "Wretborn", "given": "Jens", "initials": "J"}, {"family": "J\u00f6rg", "given": "Matthias", "initials": "M"}, {"family": "Benjaminsson Nyberg", "given": "Patrik", "initials": "P"}, {"family": "Wilhelms", "given": "Daniel B", "initials": "DB"}], "type": "observational study", "published": "2023-04-04", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "13", "issue": "1", "pages": "5469", "issn-l": "2045-2322"}, "abstract": "To establish the impact of COVID-19 on the pre-test probability for VTE in patients with suspected VTE. This was a retrospective, observational, cross-sectional study of patients 18 years and older undergoing diagnostic tests for VTE in an integrated healthcare system covering a population of 465,000 during the calendar year of 2020. We adjusted for risk factors such as age, sex, previous VTE, ongoing anticoagulant treatment, malignancy, Charlson score, ward care, ICU care and wave of COVID-19. In total, 303 of 5041 patients had a positive diagnosis of COVID-19 around the time of investigation. The prevalence of VTE in COVID-positive patients was 10.2% (36/354), 14.7% (473/3219) in COVID-19 negative patients, and 15.6% (399/2589) in patients without a COVID-19 test. A COVID-positive status was not associated with an increased risk for VTE (crude odds ratio 0.64, 95% CI 0.45-0.91, adjusted odds ratio 0.46, 95%CI 0.19-1.16). We found no increased VTE risk in COVID-positive patients. This indicates that COVID-19 status should not influence VTE workup.The study was pre-registered on May 26, 2020 at ClinicalTrials.gov with identifier NCT04400877.", "doi": "10.1038/s41598-023-32637-x", "pmid": "37015984", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10071240"}, {"db": "pii", "key": "10.1038/s41598-023-32637-x"}, {"db": "ClinicalTrials.gov", "key": "NCT04400877"}], "notes": [], "created": "2023-04-20T17:34:09.863Z", "modified": "2023-04-20T17:34:31.386Z"}, {"entity": "publication", "iuid": "8fb56fd42b8c40bab2e6d38faf82c335", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8fb56fd42b8c40bab2e6d38faf82c335.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8fb56fd42b8c40bab2e6d38faf82c335"}}, "title": "The influence of meteorological factors on COVID-19 spread in Italy during the first and second wave.", "authors": [{"family": "Balboni", "given": "Erica", "initials": "E"}, {"family": "Filippini", "given": "Tommaso", "initials": "T"}, {"family": "Rothman", "given": "Kenneth J", "initials": "KJ"}, {"family": "Costanzini", "given": "Sofia", "initials": "S"}, {"family": "Bellino", "given": "Stefania", "initials": "S"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Brusaferro", "given": "Silvio", "initials": "S"}, {"family": "Ferrari", "given": "Fabrizio", "initials": "F"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}, {"family": "Teggi", "given": "Sergio", "initials": "S"}, {"family": "Vinceti", "given": "Marco", "initials": "M"}], "type": "journal article", "published": "2023-04-03", "journal": {"title": "Environ Res", "issn": "1096-0953", "volume": "228", "pages": "115796", "issn-l": "0013-9351"}, "abstract": "The relation between meteorological factors and COVID-19 spread remains uncertain, particularly with regard to the role of temperature, relative humidity and solar ultraviolet (UV) radiation. To assess this relation, we investigated disease spread within Italy during 2020. The pandemic had a large and early impact in Italy, and during 2020 the effects of vaccination and viral variants had not yet complicated the dynamics. We used non-linear, spline-based Poisson regression of modeled temperature, UV and relative humidity, adjusting for mobility patterns and additional confounders, to estimate daily rates of COVID-19 new cases, hospital and intensive care unit admissions, and deaths during the two waves of the pandemic in Italy during 2020. We found little association between relative humidity and COVID-19 endpoints in both waves, whereas UV radiation above 40 kJ/m2 showed a weak inverse association with hospital and ICU admissions in the first wave, and a stronger relation with all COVID-19 endpoints in the second wave. Temperature above 283 K (10 \u00b0C/50 \u00b0F) showed a strong non-linear negative relation with COVID-19 endpoints, with inconsistent relations below this cutpoint in the two waves. Given the biological plausibility of a relation between temperature and COVID-19, these data add support to the proposition that temperature above 283 K, and possibly high levels of solar UV radiation, reduced COVID-19 spread.", "doi": "10.1016/j.envres.2023.115796", "pmid": "37019296", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10069087"}, {"db": "pii", "key": "S0013-9351(23)00588-1"}], "notes": [], "created": "2023-04-20T17:32:35.870Z", "modified": "2023-04-20T17:32:35.873Z"}, {"entity": "publication", "iuid": "247606a2b6ef4131a55e51ce4a162a24", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/247606a2b6ef4131a55e51ce4a162a24.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/247606a2b6ef4131a55e51ce4a162a24"}}, "title": "Missed opportunities in using lessons from HIV response to combat COVID-19 - looking back while preparing for the next pandemic.", "authors": [{"family": "Panakadan", "given": "Salil", "initials": "S"}, {"family": "Gun", "given": "Arkaprabha", "initials": "A"}, {"family": "Sarkar", "given": "Swarup", "initials": "S"}], "type": "journal article", "published": "2023-04-03", "journal": {"title": "Indian J Med Res", "issn": "0971-5916", "issn-l": null}, "abstract": null, "doi": "10.4103/ijmr.ijmr_313_23", "pmid": "37006024", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "373426"}], "notes": [], "created": "2023-04-20T17:39:44.490Z", "modified": "2023-04-20T17:39:44.507Z"}, {"entity": "publication", "iuid": "e9fd703334084370af67f4e335bed340", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e9fd703334084370af67f4e335bed340.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e9fd703334084370af67f4e335bed340"}}, "title": "Flares after COVID-19 infection in patients with idiopathic inflammatory myopathies: results from the COVAD study.", "authors": [{"family": "Ali", "given": "Sasha Saadia", "initials": "SS"}, {"family": "R", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Saha", "given": "Sreoshy", "initials": "S", "orcid": "0000-0001-6745-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00238845dd4833ae51ffb75e2fe144.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Jagtap", "given": "Kshitij", "initials": "K", "orcid": "0000-0003-2729-737X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822b9da98e5d4eb2975ff97fe484933f.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Edgar Gracia-Ramos", "given": "Abraham", "initials": "A", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Chen", "given": "Yi Ming", "initials": "YM", "orcid": "0000-0001-7593-3065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/795f1bf1d4824521a3301f7c50f62bc4.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-0986-8354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2e6226ae5e7427fbf52e180dd14e28f.json"}}, {"family": "Patel", "given": "Aarat", "initials": "A"}, {"family": "Pauling", "given": "John D", "initials": "JD", "orcid": "0000-0002-2793-2364", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e37709273d404d17a88c7c850777b99f.json"}}, {"family": "Wincup", "given": "Chris", "initials": "C", "orcid": "0000-0002-8742-8311", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a674f02e7f7f45f58167eb24f81502f3.json"}}, {"family": "Barman", "given": "Bhupen", "initials": "B", "orcid": "0000-0002-5433-1310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7747785ec5fa4743bc70bd20fbca10fd.json"}}, {"family": "Zamora Tehozol", "given": "Erick Adrian", "initials": "EA", "orcid": "0000-0002-7888-3961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a55c695ac4f4003993a2f511cca7739.json"}}, {"family": "Rojas Serrano", "given": "Jorge", "initials": "J", "orcid": "0000-0001-6980-7898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/225fd8b396ac40f4a77f1ec229c086b6.json"}}, {"family": "La Torre", "given": "Ignacio Garc\u00eda-De", "initials": "IG", "orcid": "0000-0002-9261-678X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/086b85d66fb84b50bd51bbe5a979dfe3.json"}}, {"family": "Colunga-Pedraza", "given": "Iris J", "initials": "IJ", "orcid": "0000-0002-2786-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50e46ef2c7f44b39a1d28fea6a8e621d.json"}}, {"family": "Merayo-Chalico", "given": "Javier", "initials": "J", "orcid": "0000-0002-5870-0523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d74c0ab33cbe4df586e1a1add37d0e65.json"}}, {"family": "Chibuzo", "given": "Okwara Celestine", "initials": "OC"}, {"family": "Katchamart", "given": "Wanruchada", "initials": "W", "orcid": "0000-0002-8952-5967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9439933b38fb49aca8fdbb5038ff603c.json"}}, {"family": "Goo", "given": "Phonpen Akawatcharangura", "initials": "PA"}, {"family": "Shumnalieva", "given": "Russka", "initials": "R", "orcid": "0000-0003-2321-6536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/933232cd7feb48ee81b5971f01f52e23.json"}}, {"family": "Hoff", "given": "Leonardo Santos", "initials": "LS", "orcid": "0000-0002-2083-4796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1df7af8caf024ca39c57278fdf18c766.json"}}, {"family": "El Kibbi", "given": "Lina", "initials": "L", "orcid": "0000-0003-1710-9996", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11bb4fc524264c6897dec9642a0ef7cd.json"}}, {"family": "Halabi", "given": "Hussein", "initials": "H", "orcid": "0000-0002-5174-8292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb337090a5ab4461a07e8620bee1b4b9.json"}}, {"family": "Vaidya", "given": "Binit", "initials": "B", "orcid": "0000-0002-4840-8924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b2296d53fe14fc7a8415f26e03e1944.json"}}, {"family": "Shaharir", "given": "Syahrul Sazliyana", "initials": "SS", "orcid": "0000-0002-9068-8114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1e6310979d44d58b548c61c733412af.json"}}, {"family": "Hasan", "given": "A T M Tanveer", "initials": "ATMT", "orcid": "0000-0002-5332-3319", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ffdb3329292438fac4005923ee79012.json"}}, {"family": "Dey", "given": "Dzifa", "initials": "D", "orcid": "0000-0002-3339-5112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2615e43aeba34a0585679bdd14a1a324.json"}}, {"family": "Guti\u00e9rrez", "given": "Carlos Enrique Toro", "initials": "CET", "orcid": "0000-0002-6084-7049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/980e455c5d114caaaefb6e0b55eaa3b3.json"}}, {"family": "Caballero-Uribe", "given": "Carlo Vinicio", "initials": "CV", "orcid": "0000-0002-9845-8620", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42d86c9923424f9a804bab4580b993c3.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "COVAD study group", "given": "", "initials": ""}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}], "type": "journal article", "published": "2023-04-02", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "issn-l": null}, "abstract": null, "doi": "10.1093/rheumatology/kead149", "pmid": "37004201", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7099604"}], "notes": [], "created": "2023-04-20T17:40:10.413Z", "modified": "2023-04-20T17:40:11.317Z"}, {"entity": "publication", "iuid": "229dabd823ed479fb027ca750381cb48", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/229dabd823ed479fb027ca750381cb48.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/229dabd823ed479fb027ca750381cb48"}}, "title": "Setting an Agenda: Results of a Consensus Process on Research Directions in Distance Simulation.", "authors": [{"family": "Gross", "given": "Isabel T", "initials": "IT"}, {"family": "Clapper", "given": "Timothy C", "initials": "TC"}, {"family": "Ramachandra", "given": "Geethanjali", "initials": "G"}, {"family": "Thomas", "given": "Anita", "initials": "A"}, {"family": "Ades", "given": "Anne", "initials": "A"}, {"family": "Walsh", "given": "Barbara", "initials": "B"}, {"family": "Kreuzer", "given": "Florian", "initials": "F"}, {"family": "Elkin", "given": "Rachel", "initials": "R"}, {"family": "Wagner", "given": "Michael", "initials": "M"}, {"family": "Whitfill", "given": "Travis", "initials": "T"}, {"family": "Chang", "given": "Todd P", "initials": "TP"}, {"family": "Duff", "given": "Jonathan P", "initials": "JP"}, {"family": "Deutsch", "given": "Ellen S", "initials": "ES"}, {"family": "Loellgen", "given": "Ruth M", "initials": "RM"}, {"family": "Palaganas", "given": "Janice C", "initials": "JC"}, {"family": "Fayyaz", "given": "Jabeen", "initials": "J"}, {"family": "Kessler", "given": "David", "initials": "D"}, {"family": "Calhoun", "given": "Aaron W", "initials": "AW"}], "type": "review", "published": "2023-04-01", "journal": {"title": "Simul Healthc", "issn": "1559-713X", "volume": "18", "issue": "2", "pages": "100-107", "issn-l": null}, "abstract": "The COVID-19 pandemic forced rapid implementation and refinement of distance simulation methodologies in which participants and/or facilitators are not physically colocated. A review of the distance simulation literature showed that heterogeneity in many areas (including nomenclature, methodology, and outcomes) limited the ability to identify best practice. In April 2020, the Healthcare Distance Simulation Collaboration was formed with the goal of addressing these issues. The aim of this study was to identify future research priorities in the field of distance simulation using data derived from this summit.\n\nThis study analyzed textual data gathered during the consensus process conducted at the inaugural Healthcare Distance Simulation Summit to explore participant perceptions of the most pressing research questions regarding distance simulation. Participants discussed education and patient safety standards, simulation facilitators and barriers, and research priorities. Data were qualitatively analyzed using an explicitly constructivist thematic analysis approach, resulting in the creation of a theoretical framework.\n\nOur sample included 302 participants who represented 29 countries. We identified 42 codes clustered within 4 themes concerning key areas in which further research into distance simulation is needed: (1) safety and acceptability, (2) educational/foundational considerations, (3) impact, and (4) areas of ongoing exploration. Within each theme, pertinent research questions were identified and categorized.\n\nDistance simulation presents several challenges and opportunities. Research around best practices, including educational foundation and psychological safety, are especially important as is the need to determine outcomes and long-term effects of this emerging field.", "doi": "10.1097/SIH.0000000000000663", "pmid": "36989108", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "01266021-202304000-00004"}], "notes": [], "created": "2023-04-21T15:55:55.001Z", "modified": "2023-04-21T15:55:55.021Z"}, {"entity": "publication", "iuid": "f5cdf5e7e60f43279f920149fd093bdc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f5cdf5e7e60f43279f920149fd093bdc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f5cdf5e7e60f43279f920149fd093bdc"}}, "title": "Outcome of SARS-CoV2 infection in hematopoietic stem cell transplant recipients for autoimmune diseases.", "authors": [{"family": "Greco", "given": "Raffaella", "initials": "R"}, {"family": "Snowden", "given": "John A", "initials": "JA"}, {"family": "Knelange", "given": "Nina Simone", "initials": "NS"}, {"family": "Tridello", "given": "Gloria", "initials": "G"}, {"family": "Cacciatore", "given": "Carlotta", "initials": "C"}, {"family": "Xhaard", "given": "Alienor", "initials": "A"}, {"family": "Ciceri", "given": "Fabio", "initials": "F"}, {"family": "Collin", "given": "Matthew", "initials": "M"}, {"family": "Ferra", "given": "Christelle", "initials": "C"}, {"family": "De Becker", "given": "Ann", "initials": "A"}, {"family": "Badoglio", "given": "Manuela", "initials": "M"}, {"family": "Averbuch", "given": "Dina", "initials": "D"}, {"family": "Alexander", "given": "Tobias", "initials": "T"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "De la Camara", "given": "Rafael", "initials": "R"}, {"family": "European Society for Blood and Marrow Transplantation (EBMT) COVID19 Task Force, Autoimmune Diseases Working Party (ADWP) and Infectious Diseases Working Party (IDWP)", "given": "", "initials": ""}], "type": "multicenter study", "published": "2023-04-00", "journal": {"title": "J Autoimmun", "issn": "1095-9157", "volume": "136", "pages": "103024", "issn-l": null}, "abstract": "Hematopoietic stem cell transplant (HSCT) recipients may be at high risk of mortality from coronavirus disease 2019 (COVID-19). However, specific data on COVID-19 after treatment with HSCT in patients affected by autoimmune diseases (ADs) are still lacking. In this multicenter observational study of the European Society for Blood and Marrow Transplantation (EBMT), clinical data on COVID-19 in 11 patients affected by severe ADs treated with HSCT (n = 3 allogeneic transplant; n = 8 autologous transplant) are reported. All patients were symptomatic during the initial phase of the SARS-CoV-2 infection. At screening, 5 patients reported upper respiratory symptoms, 3 patients had cough without oxygen requirement, and 6 patients exhibited extra-pulmonary symptoms. Four cases developed a lower respiratory tract disease (LRTD). Hospitalization was required in 6 cases, without necessity of intensive care unit (ICU) admission and/or ventilation/supplemental oxygen. Different interventions were adopted: remdesivir (n = 1), nirmatrelvir/ritonavir (n = 1), sotrovimab (n = 1), immunoglobulins (n = 1). At last follow-up, all patients are alive and had resolution of the infection. The current analysis describing the mild-moderate course of COVID-19 in transplant recipients affected by ADs, similar to the course observed in ADs under standard treatments, provides useful information to support the delivery of HSCT programs in this field. Vaccination and new treatments available for SARS-CoV-2 may be useful to further minimize the risk of infection.", "doi": "10.1016/j.jaut.2023.103024", "pmid": "37001437", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9977622"}, {"db": "pii", "key": "S0896-8411(23)00033-1"}], "notes": [], "created": "2023-04-20T17:41:50.640Z", "modified": "2023-04-20T17:41:50.654Z"}, {"entity": "publication", "iuid": "6084019b59d24fceb0530a9ee8bfd452", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6084019b59d24fceb0530a9ee8bfd452.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6084019b59d24fceb0530a9ee8bfd452"}}, "title": "Non-communicable disease policy implementation from 2014 to 2021: a repeated cross-sectional analysis of global policy data for 194 countries.", "authors": [{"family": "Allen", "given": "Luke N", "initials": "LN"}, {"family": "Wigley", "given": "Simon", "initials": "S"}, {"family": "Holmer", "given": "Hampus", "initials": "H"}, {"family": "Barlow", "given": "Pepita", "initials": "P"}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "Lancet Glob Health", "issn": "2214-109X", "volume": "11", "issue": "4", "pages": "e525-e533", "issn-l": null}, "abstract": "Non-communicable diseases (NCDs) are the world's leading cause of death and disability. Global implementation of WHO-recommended NCD policies has been increasing with time, but in 2019 fewer than half of these policies had been implemented globally. In 2022, WHO released updated data on NCD policy implementation, on the basis of surveys conducted in 2021 during the COVID-19 pandemic. We sought to examine whether the trajectory of global policy implementation changed during this period.\n\nIn this repeated cross-sectional analysis, we used data from the 2015, 2017, 2020, and 2022 WHO progress monitors to calculate NCD policy implementation scores for all 194 WHO member states. We used Welch's ANOVA and Games-Howell post-hoc pairwise testing to examine changes in mean implementation scores for 19 WHO-recommended NCD policies, with assessment at the global, geographical, geopolitical, and country-income levels. We collated sales data on tobacco, alcohol, and junk foods to examine the association between changes in sales and the predicted probability of implementation of policies targeting these products. We also calculated the Corporate Financial Influence Index (CFII) for each country, which was used to assess the association between corporate influence and policy implementation. We used logistic regression to assess the relationship between product sales and the probability of implementing related policies. The relationship between CFII and policy implementation was assessed with Pearson's correlation analysis and random-effects multivariate regression.\n\nAcross the 194 countries, in the years preceding publication of each progress monitor, mean total policy implementation score (out of a potential 18\u00b70) was 7\u00b70 (SD 3\u00b75) in 2014, 8\u00b72 (3\u00b75) in 2016, 8\u00b76 (3\u00b76) in 2019, and 8\u00b76 (3\u00b76) in 2021. Only the differences in mean implementation score between 2014 and the other three report years were deemed statistically significant (pairwise p<0\u00b705). Thus the steady improvement in mean global NCD policy implementation stalled in 2021 at 47\u00b78%. However, from 2019 to 2021, we identified shifts in individual policies: global mean implementation scores increased for policies on tobacco, clinical guidelines, salt, and child food marketing, and decreased for policies on alcohol, breastmilk substitute marketing, physical activity mass media campaigns, risk factor surveys, and national NCD plans and targets. Six of the seven policies with the lowest levels of implementation (global mean score <0\u00b74 out of a potential 1\u00b70) in both 2019 and 2021 were related to tobacco, alcohol, and unhealthy food. From 2020 onwards, we identified weak or no associations between sales of tobacco, alcohol, and junk foods and the predicted probability of implementing policies related to each commodity. Country-level CFII was significantly associated with total policy implementation score (Pearson's r -0\u00b749, 95% CI -0\u00b759 to -0\u00b736), and this finding was supported in multivariate modelling for all policies combined and for all commercial policies except alcohol policies.\n\nNCD policy implementation has stagnated. Progress in the implementation of some policies is matched by decreased implementation of others, particularly those related to unhealthy commodities. To prevent NCDs and their consequences, and attain the Sustainable Development Goals, the rate of NCD policy adoption must be substantially and urgently increased before the next NCD progress monitor and UN high-level meeting on NCDs in 2024.\n\nNone.", "doi": "10.1016/S2214-109X(23)00042-6", "pmid": "36925173", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2214-109X(23)00042-6"}], "notes": [], "created": "2023-04-21T16:12:27.828Z", "modified": "2023-04-21T16:12:27.845Z"}, {"entity": "publication", "iuid": "c06838cf20b24f98b0b4adb60797e096", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c06838cf20b24f98b0b4adb60797e096.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c06838cf20b24f98b0b4adb60797e096"}}, "title": "Nirmatrelvir/ritonavir in COVID-19 patients with haematological malignancies: a report from the EPICOVIDEHA registry.", "authors": [{"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J"}, {"family": "Marchesi", "given": "Francesco", "initials": "F"}, {"family": "Gomes da Silva", "given": "Maria", "initials": "M"}, {"family": "Farina", "given": "Francesca", "initials": "F"}, {"family": "D\u00e1vila-Valls", "given": "Julio", "initials": "J"}, {"family": "Bilgin", "given": "Yavuz M", "initials": "YM"}, {"family": "Glenth\u00f8j", "given": "Andreas", "initials": "A"}, {"family": "Falces-Romero", "given": "Iker", "initials": "I"}, {"family": "Van Doesum", "given": "Jaap", "initials": "J"}, {"family": "Labrador", "given": "Jorge", "initials": "J"}, {"family": "Buquicchio", "given": "Caterina", "initials": "C"}, {"family": "El-Ashwah", "given": "Shaimaa", "initials": "S"}, {"family": "Petzer", "given": "Verena", "initials": "V"}, {"family": "Van Praet", "given": "Jens", "initials": "J"}, {"family": "Sch\u00f6nlein", "given": "Martin", "initials": "M"}, {"family": "Dargenio", "given": "Michelina", "initials": "M"}, {"family": "M\u00e9ndez", "given": "Gustavo-Adolfo", "initials": "GA"}, {"family": "Meers", "given": "Stef", "initials": "S"}, {"family": "Itri", "given": "Federico", "initials": "F"}, {"family": "Giordano", "given": "Antonio", "initials": "A"}, {"family": "Pincz\u00e9s", "given": "L\u00e1szl\u00f3 Imre", "initials": "LI"}, {"family": "Espigado", "given": "Ildefonso", "initials": "I"}, {"family": "Stojanoski", "given": "Zlate", "initials": "Z"}, {"family": "L\u00f3pez-Garc\u00eda", "given": "Alberto", "initials": "A"}, {"family": "Prezioso", "given": "Lucia", "initials": "L"}, {"family": "Jaksic", "given": "Ozren", "initials": "O"}, {"family": "Vena", "given": "Antonio", "initials": "A"}, {"family": "Fracchiolla", "given": "Nicola S", "initials": "NS"}, {"family": "Gonz\u00e1lez-L\u00f3pez", "given": "Tom\u00e1s Jos\u00e9", "initials": "TJ"}, {"family": "Colovi\u0107", "given": "Natasa", "initials": "N"}, {"family": "Delia", "given": "Mario", "initials": "M"}, {"family": "Weinbergerov\u00e1", "given": "Barbora", "initials": "B"}, {"family": "Marchetti", "given": "Monia", "initials": "M"}, {"family": "Marques de Almeida", "given": "Joyce", "initials": "J"}, {"family": "Finizio", "given": "Olimpia", "initials": "O"}, {"family": "Besson", "given": "Caroline", "initials": "C"}, {"family": "Biernat", "given": "Monika M", "initials": "MM"}, {"family": "Valkovi\u0107", "given": "Toni", "initials": "T"}, {"family": "Lahmer", "given": "Tobias", "initials": "T"}, {"family": "Cuccaro", "given": "Annarosa", "initials": "A"}, {"family": "Ormazabal-V\u00e9lez", "given": "Irati", "initials": "I"}, {"family": "Batini\u0107", "given": "Josip", "initials": "J"}, {"family": "Fern\u00e1ndez", "given": "Noem\u00ed", "initials": "N"}, {"family": "De Jonge", "given": "Nick", "initials": "N"}, {"family": "Tascini", "given": "Carlo", "initials": "C"}, {"family": "Anastasopoulou", "given": "Amalia N", "initials": "AN"}, {"family": "Dul\u00e9ry", "given": "R\u00e9my", "initials": "R"}, {"family": "Del Principe", "given": "Maria Ilaria", "initials": "MI"}, {"family": "Plantefeve", "given": "Ga\u00ebtan", "initials": "G"}, {"family": "Papa", "given": "Mario Virgilio", "initials": "MV"}, {"family": "Nucci", "given": "Marcio", "initials": "M"}, {"family": "Jim\u00e9nez", "given": "Moraima", "initials": "M"}, {"family": "Aujayeb", "given": "Avinash", "initials": "A"}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jos\u00e9-\u00c1ngel", "initials": "J\u00c1"}, {"family": "Merelli", "given": "Maria", "initials": "M"}, {"family": "Cattaneo", "given": "Chiara", "initials": "C"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Cabirta", "given": "Alba", "initials": "A"}, {"family": "Varricchio", "given": "Gina", "initials": "G"}, {"family": "Sacchi", "given": "Maria Vittoria", "initials": "MV"}, {"family": "Cordoba", "given": "Raul", "initials": "R"}, {"family": "Arellano", "given": "Elena", "initials": "E"}, {"family": "Gr\u00e4fe", "given": "Stefanie K", "initials": "SK"}, {"family": "Wolf", "given": "Dominik", "initials": "D"}, {"family": "Emarah", "given": "Ziad", "initials": "Z"}, {"family": "Ammatuna", "given": "Emanuele", "initials": "E"}, {"family": "Hersby", "given": "Ditte Stampe", "initials": "DS"}, {"family": "Mart\u00edn-P\u00e9rez", "given": "Sonia", "initials": "S"}, {"family": "Nunes Rodrigues", "given": "Raquel", "initials": "R"}, {"family": "Rahimli", "given": "Laman", "initials": "L"}, {"family": "Pagano", "given": "Livio", "initials": "L"}, {"family": "Cornely", "given": "Oliver A", "initials": "OA"}, {"family": "EPICOVIDEHA registry", "given": "", "initials": ""}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": "58", "pages": "101939", "issn-l": null}, "abstract": "Nirmatrelvir/ritonavir treatment decreases the hospitalisation rate in immunocompetent patients with COVID-19, but data on efficacy in patients with haematological malignancy are scarce. Here, we describe the outcome of nirmatrelvir/ritonavir treatment in a large cohort of the latter patients.\n\nThis is a retrospective cohort study from the multicentre EPICOVIDEHA registry (NCT04733729) on patients with haematological malignancy, who were diagnosed with COVID-19 between January and September 2022. Patients receiving nirmatrelvir/ritonavir were compared to those who did not. A logistic regression was run to determine factors associated with nirmatrelvir/ritonavir administration in our sample. Mortality between treatment groups was assessed with Kaplan-Meier survival plots after matching all the patients with a propensity score. Additionally, a Cox regression was modelled to detect factors associated with mortality in patients receiving nirmatrelvir/ritonavir.\n\nA total of 1859 patients were analysed, 117 (6%) were treated with nirmatrelvir/ritonavir, 1742 (94%) were treated otherwise. Of 117 patients receiving nirmatrelvir/ritonavir, 80% had received \u22651 anti-SARS-CoV-2 vaccine dose before COVID-19 onset, 13% of which received a 2nd vaccine booster. 5% were admitted to ICU. Nirmatrelvir/ritonavir treatment was associated with the presence of extrapulmonary symptoms at COVID-19 onset, for example anosmia, fever, rhinitis, or sinusitis (aOR 2.509, 95%CI 1.448-4.347) and 2nd vaccine booster (aOR 3.624, 95%CI 1.619-8.109). Chronic pulmonary disease (aOR 0.261, 95%CI 0.093-0.732) and obesity (aOR 0.105, 95%CI 0.014-0.776) were not associated with nirmatrelvir/ritonavir use. After propensity score matching, day-30 mortality rate in patients treated with nirmatrelvir/ritonavir was 2%, significantly lower than in patients with SARS-CoV-2 directed treatment other than nirmatrelvir/ritonavir (11%, p = 0.036). No factor was observed explaining the mortality difference in patients after nirmatrelvir/ritonavir administration.\n\nHaematological malignancy patients were more likely to receive nirmatrelvir/ritonavir when reporting extrapulmonary symptoms or 2nd vaccine booster at COVID-19 onset, as opposed to chronic pulmonary disease and obesity. The mortality rate in patients treated with nirmatrelvir/ritonavir was lower than in patients with targeted drugs other than nirmatrelvir/ritonavir.\n\nEPICOVIDEHA has received funds from Optics COMMIT (COVID-19 Unmet Medical Needs and Associated Research Extension) COVID-19 RFP program by GILEAD Science, United States (Project 2020-8223).", "doi": "10.1016/j.eclinm.2023.101939", "pmid": "37041967", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC10078172"}, {"db": "pii", "key": "S2589-5370(23)00116-5"}], "notes": [], "created": "2023-04-20T17:27:35.535Z", "modified": "2023-04-20T17:27:35.548Z"}, {"entity": "publication", "iuid": "ddb832068b7446a09e1cbe96bdfe296d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ddb832068b7446a09e1cbe96bdfe296d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ddb832068b7446a09e1cbe96bdfe296d"}}, "title": "New perspectives on respiratory syncytial virus surveillance at the national level: lessons from the COVID-19 pandemic.", "authors": [{"family": "Teirlinck", "given": "Anne C", "initials": "AC", "orcid": "0000-0002-1172-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e135044218dd473e93ce8aa1af84bfde.json"}}, {"family": "Johannesen", "given": "Caroline K", "initials": "CK"}, {"family": "Broberg", "given": "Eeva K", "initials": "EK"}, {"family": "Penttinen", "given": "Pasi", "initials": "P", "orcid": "0000-0001-6929-1086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b71cf06d6ef4127b7816b76ab9b7bf0.json"}}, {"family": "Campbell", "given": "Harry", "initials": "H"}, {"family": "Nair", "given": "Harish", "initials": "H"}, {"family": "Reeves", "given": "Rachel M", "initials": "RM", "orcid": "0000-0002-8949-1568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8dd33b5dce254580806961ea8168490a.json"}}, {"family": "B\u00f8\u00e5s", "given": "H\u00e5kon", "initials": "H", "orcid": "0000-0002-5917-1563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9cc00f104cd64e53ab58eebd46368861.json"}}, {"family": "Brytting", "given": "Mia", "initials": "M"}, {"family": "Cai", "given": "Wei", "initials": "W"}, {"family": "Carnahan", "given": "AnnaSara", "initials": "A"}, {"family": "Casalegno", "given": "Jean-Sebastien", "initials": "JS"}, {"family": "Danis", "given": "Kostas", "initials": "K", "orcid": "0000-0001-6727-7344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19a6a9cd4dc74ca19c47878e93daa5ef.json"}}, {"family": "De Gascun", "given": "Cillian", "initials": "C"}, {"family": "Ellis", "given": "Joanna", "initials": "J"}, {"family": "Emborg", "given": "Hanne-Dorthe", "initials": "HD"}, {"family": "Gijon", "given": "Manuel", "initials": "M"}, {"family": "Guiomar", "given": "Raquel", "initials": "R"}, {"family": "Hirve", "given": "Siddhivinayak S", "initials": "SS"}, {"family": "Ji\u0159incov\u00e1", "given": "Helena", "initials": "H"}, {"family": "Nohynek", "given": "Hanna", "initials": "H"}, {"family": "Oliva", "given": "Jesus Angel", "initials": "JA", "orcid": "0000-0003-4080-7864", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6aab0b9fa36a4c88ac2e9714d3adacdf.json"}}, {"family": "Osei-Yeboah", "given": "Richard", "initials": "R", "orcid": "0000-0003-4622-3691", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14dca19cd0d84d8299341d3eb1357608.json"}}, {"family": "Paget", "given": "John", "initials": "J"}, {"family": "Pakarna", "given": "Gatis", "initials": "G"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "Presser", "given": "Lance", "initials": "L"}, {"family": "Rapp", "given": "Marie", "initials": "M"}, {"family": "Reiche", "given": "Janine", "initials": "J"}, {"family": "Rodrigues", "given": "Ana Paula", "initials": "AP"}, {"family": "Sepp\u00e4l\u00e4", "given": "Elina", "initials": "E"}, {"family": "Socan", "given": "Maja", "initials": "M"}, {"family": "Szymanski", "given": "Karol", "initials": "K", "orcid": "0000-0003-3269-0774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0811c53f65a34c4285dc00e449c16033.json"}}, {"family": "Trebbien", "given": "Ramona", "initials": "R"}, {"family": "Ve\u010de\u0159ov\u00e1", "given": "Jarom\u00edra", "initials": "J"}, {"family": "van der Werf", "given": "Sylvie", "initials": "S", "orcid": "0000-0002-1148-4456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/610e999fc3fa4d24aceecf5a13122ecf.json"}}, {"family": "Zambon", "given": "Maria", "initials": "M"}, {"family": "Meijer", "given": "Adam", "initials": "A", "orcid": "0000-0001-8074-7582", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa6d8f61c7ca4618a4b00d12144bac2d.json"}}, {"family": "Fischer", "given": "Thea K", "initials": "TK"}], "type": "editorial", "published": "2023-04-00", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "volume": "61", "issue": "4", "issn-l": "0903-1936"}, "abstract": "Learning from the COVID-19 pandemic and considering the effects of this pandemic, we provide recommendations that can guide towards sustainable RSV surveillance with the potential to be integrated into the broader perspective of respiratory surveillance. https://bit.ly/40TsO0G", "doi": "10.1183/13993003.01569-2022", "pmid": "37012081", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10069872"}, {"db": "pii", "key": "61/4/2201569"}], "notes": [], "created": "2023-04-20T17:35:20.998Z", "modified": "2023-04-20T17:39:19.993Z"}, {"entity": "publication", "iuid": "6fba8541d13c406298fc41acd760220c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6fba8541d13c406298fc41acd760220c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6fba8541d13c406298fc41acd760220c"}}, "title": "Emergence and antibody evasion of BQ, BA.2.75 and SARS-CoV-2 recombinant sub-lineages in the face of maturing antibody breadth at the population level.", "authors": [{"family": "Akerman", "given": "Anouschka", "initials": "A"}, {"family": "Milogiannakis", "given": "Vanessa", "initials": "V"}, {"family": "Jean", "given": "Tyra", "initials": "T"}, {"family": "Esneau", "given": "Camille", "initials": "C"}, {"family": "Silva", "given": "Mariana Ruiz", "initials": "MR"}, {"family": "Ison", "given": "Timothy", "initials": "T"}, {"family": "Fichter", "given": "Christina", "initials": "C"}, {"family": "Lopez", "given": "Joseph A", "initials": "JA"}, {"family": "Chandra", "given": "Deborah", "initials": "D"}, {"family": "Naing", "given": "Zin", "initials": "Z"}, {"family": "Caguicla", "given": "Joanna", "initials": "J"}, {"family": "Li", "given": "Daiyang", "initials": "D"}, {"family": "Walker", "given": "Gregory", "initials": "G"}, {"family": "Amatayakul-Chantler", "given": "Supavadee", "initials": "S"}, {"family": "Roth", "given": "Nathan", "initials": "N"}, {"family": "Manni", "given": "Sandro", "initials": "S"}, {"family": "Hauser", "given": "Thomas", "initials": "T"}, {"family": "Barnes", "given": "Thomas", "initials": "T"}, {"family": "Condylios", "given": "Anna", "initials": "A"}, {"family": "Yeang", "given": "Malinna", "initials": "M"}, {"family": "Wong", "given": "Maureen", "initials": "M"}, {"family": "Foster", "given": "Charles S P", "initials": "CSP"}, {"family": "Sato", "given": "Kenta", "initials": "K"}, {"family": "Lee", "given": "Sharon", "initials": "S"}, {"family": "Song", "given": "Yang", "initials": "Y"}, {"family": "Mao", "given": "Lijun", "initials": "L"}, {"family": "Sigmund", "given": "Allison", "initials": "A"}, {"family": "Phu", "given": "Amy", "initials": "A"}, {"family": "Vande More", "given": "Ann Marie", "initials": "AM"}, {"family": "Hunt", "given": "Stephanie", "initials": "S"}, {"family": "Douglas", "given": "Mark", "initials": "M"}, {"family": "Caterson", "given": "Ian", "initials": "I"}, {"family": "Britton", "given": "Warwick", "initials": "W"}, {"family": "Sandgren", "given": "Kerrie", "initials": "K"}, {"family": "Bull", "given": "Rowena", "initials": "R"}, {"family": "Lloyd", "given": "Andrew", "initials": "A"}, {"family": "Triccas", "given": "Jamie", "initials": "J"}, {"family": "Tangye", "given": "Stuart", "initials": "S"}, {"family": "Bartlett", "given": "Nathan W", "initials": "NW"}, {"family": "Darley", "given": "David", "initials": "D"}, {"family": "Matthews", "given": "Gail", "initials": "G"}, {"family": "Stark", "given": "Damien J", "initials": "DJ"}, {"family": "Petoumenos", "given": "Kathy", "initials": "K"}, {"family": "Rawlinson", "given": "William D", "initials": "WD"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Brilot", "given": "Fabienne", "initials": "F"}, {"family": "Cunningham", "given": "Anthony L", "initials": "AL"}, {"family": "Kelleher", "given": "Anthony D", "initials": "AD"}, {"family": "Aggarwal", "given": "Anupriya", "initials": "A"}, {"family": "Turville", "given": "Stuart G", "initials": "SG"}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "volume": "90", "pages": "104545", "issn-l": null}, "abstract": "The Omicron era of the COVID-19 pandemic commenced at the beginning of 2022 and whilst it started with primarily BA.1, it was latter dominated by BA.2 and the related sub-lineage BA.5. Following resolution of the global BA.5 wave, a diverse grouping of Omicron sub-lineages emerged derived from BA.2, BA.5 and recombinants thereof. Whilst emerging from distinct lineages, all shared similar changes in the Spike glycoprotein affording them an outgrowth advantage through evasion of neutralising antibodies.\n\nOver the course of 2022, we monitored the potency and breadth of antibody neutralization responses to many emerging variants in the Australian community at three levels: (i) we tracked over 420,000 U.S. plasma donors over time through various vaccine booster roll outs and Omicron waves using sequentially collected IgG pools; (ii) we mapped the antibody response in individuals using blood from stringently curated vaccine and convalescent cohorts. (iii) finally we determine the in vitro efficacy of clinically approved therapies Evusheld and Sotrovimab.\n\nIn pooled IgG samples, we observed the maturation of neutralization breadth to Omicron variants over time through continuing vaccine and infection waves. Importantly, in many cases, we observed increased antibody breadth to variants that were yet to be in circulation. Determination of viral neutralization at the cohort level supported equivalent coverage across prior and emerging variants with isolates BQ.1.1, XBB.1, BR.2.1 and XBF the most evasive. Further, these emerging variants were resistant to Evusheld, whilst increasing neutralization resistance to Sotrovimab was restricted to BQ.1.1 and XBF. We conclude at this current point in time that dominant variants can evade antibodies at levels equivalent to their most evasive lineage counterparts but sustain an entry phenotype that continues to promote an additional outgrowth advantage. In Australia, BR.2.1 and XBF share this phenotype and, in contrast to global variants, are uniquely dominant in this region in the later months of 2022.\n\nWhilst the appearance of a diverse range of omicron lineages has led to primary or partial resistance to clinically approved monoclonal antibodies, the maturation of the antibody response across both cohorts and a large donor pools importantly observes increasing breadth in the antibody neutralisation responses over time with a trajectory that covers both current and known emerging variants.\n\nThis work was primarily supported by Australian Medical Foundation research grants MRF2005760 (SGT, GM & WDR), Medical Research Future Fund Antiviral Development Call grant (WDR), the New South Wales Health COVID-19 Research Grants Round 2 (SGT & FB) and the NSW Vaccine Infection and Immunology Collaborative (VIIM) (ALC). Variant modeling was supported by funding from SciLifeLab's Pandemic Laboratory Preparedness program to B.M. (VC-2022-0028) and by the European Union's Horizon 2020 research and innovation programme under grant agreement no. 101003653 (CoroNAb) to B.M.", "doi": "10.1016/j.ebiom.2023.104545", "pmid": "37002990", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10060887"}, {"db": "pii", "key": "S2352-3964(23)00110-X"}], "notes": [], "created": "2023-04-20T17:41:13.979Z", "modified": "2023-04-20T17:41:13.982Z"}, {"entity": "publication", "iuid": "04186ca4c37344d585b7d735b4454a72", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/04186ca4c37344d585b7d735b4454a72.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/04186ca4c37344d585b7d735b4454a72"}}, "title": "Contextualising adverse events of special interest to characterise the baseline incidence rates in 24 million patients with COVID-19 across 26 databases: a multinational retrospective cohort study.", "authors": [{"family": "Voss", "given": "Erica A", "initials": "EA"}, {"family": "Shoaibi", "given": "Azza", "initials": "A"}, {"family": "Yin Hui Lai", "given": "Lana", "initials": "L"}, {"family": "Blacketer", "given": "Clair", "initials": "C"}, {"family": "Alshammari", "given": "Thamir", "initials": "T"}, {"family": "Makadia", "given": "Rupa", "initials": "R"}, {"family": "Haynes", "given": "Kevin", "initials": "K"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Rao", "given": "Gowtham", "initials": "G"}, {"family": "van Sandijk", "given": "Sebastiaan", "initials": "S"}, {"family": "Fraboulet", "given": "Clement", "initials": "C"}, {"family": "Boyer", "given": "Laurent", "initials": "L"}, {"family": "Le Carrour", "given": "Tanguy", "initials": "T"}, {"family": "Horban", "given": "Scott", "initials": "S"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Mart\u00ednez Rold\u00e1n", "given": "Jordi", "initials": "J"}, {"family": "Ram\u00edrez-Anguita", "given": "Juan Manuel", "initials": "JM"}, {"family": "Mayer", "given": "Miguel A", "initials": "MA"}, {"family": "de Wilde", "given": "Marcel", "initials": "M"}, {"family": "John", "given": "Luis H", "initials": "LH"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "Roel", "given": "Elena", "initials": "E"}, {"family": "Pistillo", "given": "Andrea", "initials": "A"}, {"family": "Kolde", "given": "Raivo", "initials": "R"}, {"family": "Maljkovi\u0107", "given": "Filip", "initials": "F"}, {"family": "Denaxas", "given": "Spiros", "initials": "S"}, {"family": "Papez", "given": "Vaclav", "initials": "V"}, {"family": "Kahn", "given": "Michael G", "initials": "MG"}, {"family": "Natarajan", "given": "Karthik", "initials": "K"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Secora", "given": "Alex", "initials": "A"}, {"family": "Minty", "given": "Evan P", "initials": "EP"}, {"family": "Shah", "given": "Nigam H", "initials": "NH"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Garcia Morales", "given": "Maria Teresa", "initials": "MT"}, {"family": "Bosca", "given": "Diego", "initials": "D"}, {"family": "Cadenas Juanino", "given": "Honorio", "initials": "H"}, {"family": "Diaz Holgado", "given": "Antonio", "initials": "A"}, {"family": "Pedrera Jim\u00e9nez", "given": "Miguel", "initials": "M"}, {"family": "Serrano Balazote", "given": "Pablo", "initials": "P"}, {"family": "Garc\u00eda Barrio", "given": "Noelia", "initials": "N"}, {"family": "\u015een", "given": "Sel\u00e7uk", "initials": "S"}, {"family": "\u00dcresin", "given": "Ali Ya\u011f\u0131z", "initials": "AY"}, {"family": "Erdogan", "given": "Baris", "initials": "B"}, {"family": "Belmans", "given": "Luc", "initials": "L"}, {"family": "Byttebier", "given": "Geert", "initials": "G"}, {"family": "Malbrain", "given": "Manu L N G", "initials": "MLNG"}, {"family": "Dedman", "given": "Daniel J", "initials": "DJ"}, {"family": "Cuccu", "given": "Zara", "initials": "Z"}, {"family": "Vashisht", "given": "Rohit", "initials": "R"}, {"family": "Butte", "given": "Atul J", "initials": "AJ"}, {"family": "Patel", "given": "Ayan", "initials": "A"}, {"family": "Dahm", "given": "Lisa", "initials": "L"}, {"family": "Han", "given": "Cora", "initials": "C"}, {"family": "Bu", "given": "Fan", "initials": "F"}, {"family": "Arshad", "given": "Faaizah", "initials": "F"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Prieto-Alhambra", "given": "Dani", "initials": "D"}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR"}, {"family": "Schuemie", "given": "Martijn J", "initials": "MJ"}, {"family": "Ryan", "given": "Patrick B", "initials": "PB"}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": "58", "pages": "101932", "issn-l": null}, "abstract": "Adverse events of special interest (AESIs) were pre-specified to be monitored for the COVID-19 vaccines. Some AESIs are not only associated with the vaccines, but with COVID-19. Our aim was to characterise the incidence rates of AESIs following SARS-CoV-2 infection in patients and compare these to historical rates in the general population.\n\nA multi-national cohort study with data from primary care, electronic health records, and insurance claims mapped to a common data model. This study's evidence was collected between Jan 1, 2017 and the conclusion of each database (which ranged from Jul 2020 to May 2022). The 16 pre-specified prevalent AESIs were: acute myocardial infarction, anaphylaxis, appendicitis, Bell's palsy, deep vein thrombosis, disseminated intravascular coagulation, encephalomyelitis, Guillain- Barr\u00e9 syndrome, haemorrhagic stroke, non-haemorrhagic stroke, immune thrombocytopenia, myocarditis/pericarditis, narcolepsy, pulmonary embolism, transverse myelitis, and thrombosis with thrombocytopenia. Age-sex standardised incidence rate ratios (SIR) were estimated to compare post-COVID-19 to pre-pandemic rates in each of the databases.\n\nSubstantial heterogeneity by age was seen for AESI rates, with some clearly increasing with age but others following the opposite trend. Similarly, differences were also observed across databases for same health outcome and age-sex strata. All studied AESIs appeared consistently more common in the post-COVID-19 compared to the historical cohorts, with related meta-analytic SIRs ranging from 1.32 (1.05 to 1.66) for narcolepsy to 11.70 (10.10 to 13.70) for pulmonary embolism.\n\nOur findings suggest all AESIs are more common after COVID-19 than in the general population. Thromboembolic events were particularly common, and over 10-fold more so. More research is needed to contextualise post-COVID-19 complications in the longer term.\n\nNone.", "doi": "10.1016/j.eclinm.2023.101932", "pmid": "37034358", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10072853"}, {"db": "pii", "key": "S2589-5370(23)00109-8"}], "notes": [], "created": "2023-04-20T17:29:48.848Z", "modified": "2023-04-20T17:29:48.862Z"}, {"entity": "publication", "iuid": "02795f7098f24bff96850deb84f65aac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02795f7098f24bff96850deb84f65aac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02795f7098f24bff96850deb84f65aac"}}, "title": "Changes in sexual activities, function, and satisfaction during the COVID-19 pandemic era: a systematic review and meta-analysis.", "authors": [{"family": "Qaderi", "given": "Kowsar", "initials": "K"}, {"family": "Yazdkhasti", "given": "Mansoureh", "initials": "M"}, {"family": "Zangeneh", "given": "Sanaz", "initials": "S"}, {"family": "Behbahani", "given": "Bahar Morshed", "initials": "BM"}, {"family": "Kalhor", "given": "Mehri", "initials": "M"}, {"family": "Shamsabadi", "given": "Ahmadreza", "initials": "A"}, {"family": "Jesmani", "given": "Younes", "initials": "Y"}, {"family": "Norouzi", "given": "Solmaz", "initials": "S"}, {"family": "Kajbafvala", "given": "Mehrnaz", "initials": "M"}, {"family": "Khodavirdilou", "given": "Rasa", "initials": "R"}, {"family": "Rahmani", "given": "Nahid", "initials": "N"}, {"family": "Namadian", "given": "Masoumeh", "initials": "M"}, {"family": "Ezabadi", "given": "Sajjad Ghane", "initials": "SG"}, {"family": "Alkatout", "given": "Ibrahim", "initials": "I"}, {"family": "Mehraeen", "given": "Esmaeel", "initials": "E"}, {"family": "Rasoal", "given": "Dara", "initials": "D"}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "Sex Med", "issn": "2050-1161", "volume": "11", "issue": "2", "pages": "qfad005", "issn-l": null}, "abstract": "Little is known about the impact of the coronavirus on sexual behavior, function, and satisfaction.\n\nThe aim of the present study was to systematically review people's sexual function and behaviors and their changes in sexual activities during the COVID-19 pandemic.\n\nComprehensive searches in PubMed, Web of Science, and Scopus were conducted with keywords in accordance with MeSH terms: COVID-19, SARS-CoV-2, coronavirus, sexual health, sexual function, sexual dysfunctions, sexuality, sexual orientation, sexual activities, and premarital sex. Two reviewers independently assessed full-text articles according to predefined criteria: original design, English studies, and investigating either the general population or sexual minorities.\n\nRisk of bias in the studies was assessed by the Newcastle-Ottawa Scale, and data were pooled via random effects meta-analyses. We utilized the standardized mean difference to evaluate the effects of the COVID-19 pandemic on sexual activity, functioning, and satisfaction. We included 19 studies in the analysis and 11 studies in the meta-analysis, with a sample size of 12 350. To investigate sexual activity changes, a sample size of 8838 was entered into the subgroup analysis, which showed a significant decrease in both genders (5821 women, P < .033; 3017 men, P < .008). A subgroup meta-analysis showed that the sexual function of men and women during the COVID-19 pandemic significantly declined (3974 women, P < .001; 1427 men, P < .001). Sexual desire and arousal decreased in both genders, though mainly in women. In investigating sexual satisfaction changes during the COVID-19 pandemic, a meta-analysis with a sample size of 2711 showed a significant decrease (P < .001). The most indicative changes in sexual behaviors during the pandemic were the increase in masturbating and usage of sex toys. Greater COVID-19 knowledge was associated with lower masturbation, oral sex, and vaginal sex. The more protective behaviors were associated with less hugging, kissing, cuddling, genital touching, watching porn with a partner, and vaginal sex.\n\nThe COVID-19 pandemic led to increased challenges and changes for individuals' sexual behaviors. Efforts for preventive strategies should therefore be concentrated between pandemics, while ensuring that there is information available to the population during a pandemic for help in times of psychological distress or crisis.", "doi": "10.1093/sexmed/qfad005", "pmid": "36970584", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10037164"}, {"db": "pii", "key": "qfad005"}], "notes": [], "created": "2023-04-21T16:00:18.555Z", "modified": "2023-04-21T16:00:42.709Z"}, {"entity": "publication", "iuid": "9187c61acefa4eae9abaaebe2dbac652", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9187c61acefa4eae9abaaebe2dbac652.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9187c61acefa4eae9abaaebe2dbac652"}}, "title": "An XAI approach for COVID-19 detection using transfer learning with X-ray images.", "authors": [{"family": "Sarp", "given": "Salih", "initials": "S"}, {"family": "Catak", "given": "Ferhat Ozgur", "initials": "FO"}, {"family": "Kuzlu", "given": "Murat", "initials": "M"}, {"family": "Cali", "given": "Umit", "initials": "U"}, {"family": "Kusetogullari", "given": "Huseyin", "initials": "H"}, {"family": "Zhao", "given": "Yanxiao", "initials": "Y"}, {"family": "Ates", "given": "Gungor", "initials": "G"}, {"family": "Guler", "given": "Ozgur", "initials": "O"}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": "9", "issue": "4", "pages": "e15137", "issn-l": null}, "abstract": "The coronavirus disease (COVID-19) has continued to cause severe challenges during this unprecedented time, affecting every part of daily life in terms of health, economics, and social development. There is an increasing demand for chest X-ray (CXR) scans, as pneumonia is the primary and vital complication of COVID-19. CXR is widely used as a screening tool for lung-related diseases due to its simple and relatively inexpensive application. However, these scans require expert radiologists to interpret the results for clinical decisions, i.e., diagnosis, treatment, and prognosis. The digitalization of various sectors, including healthcare, has accelerated during the pandemic, with the use and importance of Artificial Intelligence (AI) dramatically increasing. This paper proposes a model using an Explainable Artificial Intelligence (XAI) technique to detect and interpret COVID-19 positive CXR images. We further analyze the impact of COVID-19 positive CXR images using heatmaps. The proposed model leverages transfer learning and data augmentation techniques for faster and more adequate model training. Lung segmentation is applied to enhance the model performance further. We conducted a pre-trained network comparison with the highest classification performance (F1-Score: 98%) using the ResNet model.", "doi": "10.1016/j.heliyon.2023.e15137", "pmid": "37041935", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10080863"}, {"db": "pii", "key": "S2405-8440(23)02344-7"}], "notes": [], "created": "2023-04-20T17:27:55.201Z", "modified": "2023-04-20T17:28:06.103Z"}, {"entity": "publication", "iuid": "69c29e2854784570bf943d9f060510a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69c29e2854784570bf943d9f060510a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69c29e2854784570bf943d9f060510a6"}}, "title": "Systemic sclerosis and COVID-19 vaccine safety: short-term insights from the global COVID-19 vaccination in autoimmune disease (COVAD) survey.", "authors": [{"family": "Naveen", "given": "R", "initials": "R", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Thakare", "given": "Darpan R", "initials": "DR", "orcid": "0000-0002-6852-4869", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b89611ef037490fb80a852b74f67752.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Pauling", "given": "John D", "initials": "JD", "orcid": "0000-0002-2793-2364", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e37709273d404d17a88c7c850777b99f.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Jagtap", "given": "Kshitij", "initials": "K", "orcid": "0000-0003-2729-737X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822b9da98e5d4eb2975ff97fe484933f.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Saha", "given": "Sreoshy", "initials": "S", "orcid": "0000-0001-6745-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00238845dd4833ae51ffb75e2fe144.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Kardes", "given": "Sinan", "initials": "S", "orcid": "0000-0002-6311-8634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2900c3ca00da476a8914574384a3c9c2.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "COVAD Study Group", "given": "", "initials": ""}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}], "type": "journal article", "published": "2023-03-31", "journal": {"title": "Rheumatol Int", "issn": "1437-160X", "pages": "1-11", "issn-l": null}, "abstract": "The safety profile of COVID-19 vaccines is understudied in patients with systemic sclerosis (SSc). We compared short-term adverse events (AEs) 7 days following vaccination in patients with SSc vs other rheumatic (AIRDs), non-rheumatic autoimmune diseases (nrAIDs), and healthy controls (HCs). The COVID-19 Vaccination in autoimmune diseases (COVAD) self-reporting e-survey was circulated by a group of > 110 collaborators in 94 countries from March to December 2021. AEs were analyzed between different groups using regression models. Of 10,679 complete respondents [73.8% females, mean age 43 years, 53% Caucasians], 478 had SSc. 83% had completed two vaccine doses, Pfizer-BioNTech (BNT162b2) (51%) was the most common. Minor and major AEs were reported by 81.2% and 3.3% SSc patients, respectively, and did not differ significantly with disease activity or different vaccine types, though with minor symptom differences. Frequencies of AEs were not affected by background immunosuppression, though SSc patients receiving hydroxychloroquine experienced fatigue less commonly (OR 0.4; 95% CI 0.2-0.8). Frequency of AEs and hospitalisations were similar to other AIRDs, nrAIDs, and HC except a higher risk of chills (OR 1.3; 95% CI 1.0-1.7) and fatigue (OR 1.3; 95% CI 1.0-1.6) compared to other AIRDs. COVID-19 vaccines were largely safe and well tolerated in SSc patients in the short term. Background immunosuppression and disease activity did not influence the vaccination-related short-term AEs.", "doi": "10.1007/s00296-023-05310-9", "pmid": "37000295", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10064600"}, {"db": "pii", "key": "10.1007/s00296-023-05310-9"}], "notes": [], "created": "2023-04-20T17:42:14.492Z", "modified": "2023-04-20T17:42:21.934Z"}, {"entity": "publication", "iuid": "8a7a4dc6524c476fbdf4224540d925f6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a7a4dc6524c476fbdf4224540d925f6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a7a4dc6524c476fbdf4224540d925f6"}}, "title": "Ionizable lipids penetrate phospholipid bilayers with high phase transition temperatures: perspectives from free energy calculations.", "authors": [{"family": "Ermilova", "given": "Inna", "initials": "I"}, {"family": "Swenson", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2023-03-31", "journal": {"title": "Chem Phys Lipids", "issn": "1873-2941", "volume": "253", "pages": "105294", "issn-l": null}, "abstract": "The efficacies of modern gene-therapies strongly depend on their contents. At the same time the most potent formulations might not contain the best compounds. In this work we investigated the effect of phospholipids and their saturation on the binding ability of (6Z,9Z,28Z,31Z)-heptatriacont-6,9,28,31-tetraene-19-yl 4-(dimethylamino) butanoate (DLin-MC3-DMA) to model membranes at the neutral pH. We discovered that DLin-MC3-DMA has affinity to the most saturated monocomponent lipid bilayer 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and an aversion to the unsaturated one 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC). The preference to a certain membrane was also well-correlated to the phase transition temperatures of phospholipid bilayers, and to their structural and dynamical properties. Additionally, in the case of the presence of DLin-MC3-DMA in the membrane with DOPC the ionizable lipid penetrated it, which indicates possible synergistic effects. Comparisons with other ionizable lipids were performed using a model lipid bilayer of 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine (POPC). Particularly, the lipids heptadecan-9-yl 8-[2-hydroxyethyl-(6-oxo-6-undecoxyhexyl)amino]octanoate (SM-102) and [(4-hydroxybutyl) azanediyl] di(hexane-6,1-diyl) bis(2-hexyldecanoate) (ALC-0315) from modern mRNA-vaccines against COVID-19 were investigated and force fields parameters were derived for those new lipids. It was discovered that ALC-0315 binds strongest to the membrane, while DLin-MC3-DMA is not able to reside in the bilayer center. The ability to penetrate the membrane POPC by SM-102 and ALC-0315 can be related to their saturation, comparing to DLin-MC3-DMA.", "doi": "10.1016/j.chemphyslip.2023.105294", "pmid": "37003484", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0009-3084(23)00016-6"}], "notes": [], "created": "2023-04-20T17:40:26.665Z", "modified": "2023-04-20T17:40:26.698Z"}, {"entity": "publication", "iuid": "f937469419534ab381cfbf50a42f32f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f937469419534ab381cfbf50a42f32f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f937469419534ab381cfbf50a42f32f7"}}, "title": "Addressing global disparities in blood pressure control: perspectives of the International Society of Hypertension.", "authors": [{"family": "Schutte", "given": "Aletta E", "initials": "AE", "orcid": "0000-0001-9217-4937", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/101d8070a2cb43b198f974d3c40eaa4c.json"}}, {"family": "Jafar", "given": "Tazeen H", "initials": "TH", "orcid": "0000-0001-7454-8376", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96c13f8991f54072b38dcf21358e886b.json"}}, {"family": "Poulter", "given": "Neil R", "initials": "NR", "orcid": "0000-0002-6292-997X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4533dad3e82f4033bd1759f6792d60ee.json"}}, {"family": "Damasceno", "given": "Albertino", "initials": "A", "orcid": "0000-0002-5547-0224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2545cf0bbaf46629c6a5b0df1e0a887.json"}}, {"family": "Khan", "given": "Nadia A", "initials": "NA"}, {"family": "Nilsson", "given": "Peter M", "initials": "PM", "orcid": "0000-0002-5652-8459", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24f3c955840443a2a7b61839834ca30c.json"}}, {"family": "Alsaid", "given": "Jafar", "initials": "J", "orcid": "0000-0002-0269-5630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8033a5b1ce92459ea5aac83edc94b770.json"}}, {"family": "Neupane", "given": "Dinesh", "initials": "D", "orcid": "0000-0002-1501-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cdf496b02ca4c75ae012d8b88fd2513.json"}}, {"family": "Kario", "given": "Kazuomi", "initials": "K", "orcid": "0000-0002-8251-4480", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fc9431ed85a4f28a68540e3119e63b9.json"}}, {"family": "Beheiry", "given": "Hind", "initials": "H", "orcid": "0000-0001-6905-1867", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc79ed8474c84e24b20f492877aff5d7.json"}}, {"family": "Brouwers", "given": "Sofie", "initials": "S", "orcid": "0000-0002-7081-4881", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06fb9e105ad242489f5e7d8dda926b6b.json"}}, {"family": "Burger", "given": "Dylan", "initials": "D", "orcid": "0000-0003-3951-2911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6998a09484264b42b22222219cd3dc3c.json"}}, {"family": "Charchar", "given": "Fadi J", "initials": "FJ", "orcid": "0000-0002-6164-9941", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db655f3c3bfa4a95837434be78187209.json"}}, {"family": "Cho", "given": "Myeong-Chan", "initials": "MC", "orcid": "0000-0002-0047-0227", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98ded8bfd8194c809224851131643c43.json"}}, {"family": "Guzik", "given": "Tomasz J", "initials": "TJ", "orcid": "0000-0002-5039-7849", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72f67c1d004e45d294553c8a9dec0545.json"}}, {"family": "Haji Al-Saedi", "given": "Ghazi F", "initials": "GF", "orcid": "0000-0001-5261-3106", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c2adbf00e8f4a178adb1458e3cb30bc.json"}}, {"family": "Ishaq", "given": "Muhammad", "initials": "M", "orcid": "0000-0001-9725-2164", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fadfe352b564e738c49ada92afa5700.json"}}, {"family": "Itoh", "given": "Hiroshi", "initials": "H", "orcid": "0000-0003-2514-4919", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb8fd0d9f90549a182897d73f1cb4216.json"}}, {"family": "Jones", "given": "Erika S W", "initials": "ESW", "orcid": "0000-0002-3569-3498", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62c0de53e979472aaad042d112643338.json"}}, {"family": "Khan", "given": "Taskeen", "initials": "T", "orcid": "0000-0002-1676-4895", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/829167b193864e118e478dca9414f7a8.json"}}, {"family": "Kokubo", "given": "Yoshihiro", "initials": "Y", "orcid": "0000-0002-0705-9449", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79bbc719d1a44d5db033585b9fc784e8.json"}}, {"family": "Kotruchin", "given": "Praew", "initials": "P", "orcid": "0000-0003-3519-3415", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fcfb1decd3bd451eb143bbf48db8eb64.json"}}, {"family": "Muxfeldt", "given": "Elizabeth", "initials": "E", "orcid": "0000-0003-3853-7842", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8338f3cb9cab414fbd89828994fe210c.json"}}, {"family": "Odili", "given": "Augustine", "initials": "A", "orcid": "0000-0002-4564-1587", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dff5dcd1a2604323805b91f403b8a038.json"}}, {"family": "Patil", "given": "Mansi", "initials": "M", "orcid": "0000-0002-2337-385X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03056f2f9f4544fd9f1e5f5570e6f262.json"}}, {"family": "Ralapanawa", "given": "Udaya", "initials": "U", "orcid": "0000-0002-7416-7984", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c87c01d2e0294e7dbbad6f39666e34c5.json"}}, {"family": "Romero", "given": "Cesar A", "initials": "CA", "orcid": "0000-0002-8445-9665", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/391ecd75a1b14398989524d9c016b738.json"}}, {"family": "Schlaich", "given": "Markus P", "initials": "MP", "orcid": "0000-0002-1765-0195", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/861a9872844a48718c4b20613099d65a.json"}}, {"family": "Shehab", "given": "Abdulla", "initials": "A", "orcid": "0000-0001-8533-9174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0448033a990d4e08a2736e4efabf90bc.json"}}, {"family": "Mooi", "given": "Ching Siew", "initials": "CS", "orcid": "0000-0002-4425-7989", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9209d3bf7da445ee9e69147c20860be5.json"}}, {"family": "Steckelings", "given": "U Muscha", "initials": "UM", "orcid": "0000-0002-5430-4275", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea42dcd8ea9b4a2c9b4c80bc46c4bccc.json"}}, {"family": "Stergiou", "given": "George", "initials": "G", "orcid": "0000-0002-6132-0038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87b549c63cfa4e5bb947cd868fc7318a.json"}}, {"family": "Touyz", "given": "Rhian M", "initials": "RM", "orcid": "0000-0003-0670-0887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a382d644347d432bbda6ccb135e91cff.json"}}, {"family": "Unger", "given": "Thomas", "initials": "T", "orcid": "0000-0002-0233-8705", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/afdfe83d52034a7481d6ae01a1afbd3a.json"}}, {"family": "Wainford", "given": "Richard D", "initials": "RD", "orcid": "0000-0003-2830-5618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e88bd9e155244c29985b7d5b7acba15.json"}}, {"family": "Wang", "given": "Ji-Guang", "initials": "JG", "orcid": "0000-0001-8511-1524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eafaab42fae54c97860eadc1f1e5e62b.json"}}, {"family": "Williams", "given": "Bryan", "initials": "B", "orcid": "0000-0002-8094-1841", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5491ff3f5d0245728fb17be9d4265105.json"}}, {"family": "Wynne", "given": "Brandi M", "initials": "BM", "orcid": "0000-0003-0861-4245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d76304dc88d74beb923f4bca698e3926.json"}}, {"family": "Tomaszewski", "given": "Maciej", "initials": "M", "orcid": "0000-0001-8215-6567", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f32a5e3c5d544e9a82fc9cc27bbeb9db.json"}}], "type": "journal article", "published": "2023-03-31", "journal": {"title": "Cardiovasc Res", "issn": "1755-3245", "volume": "119", "issue": "2", "pages": "381-409", "issn-l": null}, "abstract": "Raised blood pressure (BP) is the leading cause of preventable death in the world. Yet, its global prevalence is increasing, and it remains poorly detected, treated, and controlled in both high- and low-resource settings. From the perspective of members of the International Society of Hypertension based in all regions, we reflect on the past, present, and future of hypertension care, highlighting key challenges and opportunities, which are often region-specific. We report that most countries failed to show sufficient improvements in BP control rates over the past three decades, with greater improvements mainly seen in some high-income countries, also reflected in substantial reductions in the burden of cardiovascular disease and deaths. Globally, there are significant inequities and disparities based on resources, sociodemographic environment, and race with subsequent disproportionate hypertension-related outcomes. Additional unique challenges in specific regions include conflict, wars, migration, unemployment, rapid urbanization, extremely limited funding, pollution, COVID-19-related restrictions and inequalities, obesity, and excessive salt and alcohol intake. Immediate action is needed to address suboptimal hypertension care and related disparities on a global scale. We propose a Global Hypertension Care Taskforce including multiple stakeholders and societies to identify and implement actions in reducing inequities, addressing social, commercial, and environmental determinants, and strengthening health systems implement a well-designed customized quality-of-care improvement framework.", "doi": "10.1093/cvr/cvac130", "pmid": "36219457", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9619669"}, {"db": "pii", "key": "6758338"}], "notes": [], "created": "2023-04-12T16:46:53.765Z", "modified": "2023-04-12T16:46:54.891Z"}, {"entity": "publication", "iuid": "22e21e095c774dbaa7909cee0507b0d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/22e21e095c774dbaa7909cee0507b0d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/22e21e095c774dbaa7909cee0507b0d0"}}, "title": "The COPE Staff study: Study description and initial report regarding job satisfaction, work-life conflicts, stress, and burnout among Swedish maternal and neonatal healthcare workers during the COVID-19 pandemic.", "authors": [{"family": "Akerstrom", "given": "Magnus", "initials": "M", "orcid": "0000-0002-8469-6193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89ae0148df6f40cfbd1e490e317f1b03.json"}}, {"family": "Sengpiel", "given": "Verena", "initials": "V", "orcid": "0000-0002-3608-7430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d43b587b94df49f88177d0c804ba7688.json"}}, {"family": "Had\u017eibajramovi\u0107", "given": "Emina", "initials": "E", "orcid": "0000-0002-6630-8898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e56ec24563742ac987a8f5d042a1ade.json"}}, {"family": "Carlsson", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-1414-7279", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2453802e12b43008382f79aebd51ddf.json"}}, {"family": "Graner", "given": "Sofie", "initials": "S", "orcid": "0000-0003-1355-9973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e73c3b5e31c4786b42e33a47db0e82e.json"}}, {"family": "Andersson", "given": "Ola", "initials": "O", "orcid": "0000-0002-3972-0457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77b8a87b252041f094508255b8a43df5.json"}}, {"family": "Jonsson", "given": "Maria", "initials": "M", "orcid": "0000-0002-2657-1958", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ef5424eb68f4181bce3b27c17bbe964.json"}}, {"family": "Naurin", "given": "Elin", "initials": "E", "orcid": "0000-0002-7091-994X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54a0a859d7dc428289d8e60b7e90c125.json"}}, {"family": "Veje", "given": "Malin", "initials": "M", "orcid": "0000-0001-5487-0616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de2e59c2ebcf41759a06fda11b6572bd.json"}}, {"family": "Wessberg", "given": "Anna", "initials": "A", "orcid": "0000-0001-8457-9651", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69ed0ec2bf404955acf6d8735166e6db.json"}}, {"family": "Linden", "given": "Karolina", "initials": "K", "orcid": "0000-0002-2792-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a16575cbdf5a4e0ebab52acaf2404273.json"}}], "type": "journal article", "published": "2023-03-30", "journal": {"title": "Int J Gynaecol Obstet", "issn": "1879-3479", "issn-l": null}, "abstract": "To describe the study design of the COPE Staff cohort study on working conditions for maternal and neonatal healthcare workers (MNHCWs), and present baseline data regarding job satisfaction, work-life conflicts, stress, and burnout.\n\nBetween January and April 2021, 957 MNHCWs (administrative and medical staff) completed a baseline survey. Average levels of job satisfaction, work-life conflicts, stress, and burnout, and associations to perceived workload were assessed.\n\nThe average levels of job satisfaction, work-life conflicts, stress, and burnout were 68.6 (95% confidence interval [CI] 64.3-72.8), 42.6 (95% CI 37.3-48.0), 42.0 (95% CI 37.7-46.3), and 1.9 (95% CI 1.6-2.2), respectively. The respondents scoring above critical values indicating clinical burnout ranged between 3% and 18%, respectively, for the four burnout sub-dimensions. Women reported significantly higher levels of stress and burnout. Younger participants had lower job satisfaction and higher levels of work-life conflicts, stress, and burnout. Higher perceived workload was significantly associated with lower job satisfaction levels and higher levels of work-life conflicts, stress, and burnout.\n\nOur results indicate associations between MNHCWs perceived workload and job satisfaction, work-life conflicts, stress, and burnout during the COVID-19 pandemic. Eighteen percent scored above critical values for exhaustion.", "doi": "10.1002/ijgo.14772", "pmid": "36998146", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-21T15:51:23.619Z", "modified": "2023-04-21T15:51:23.853Z"}, {"entity": "publication", "iuid": "5e1ae5bfc1894e15b2929ce6df1089bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e1ae5bfc1894e15b2929ce6df1089bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e1ae5bfc1894e15b2929ce6df1089bf"}}, "title": "Process development for an effective COVID-19 vaccine candidate harboring recombinant SARS-CoV-2 delta plus receptor binding domain produced by Pichia pastoris.", "authors": [{"family": "Kalyoncu", "given": "Sibel", "initials": "S"}, {"family": "Yilmaz", "given": "Semiramis", "initials": "S"}, {"family": "Kuyucu", "given": "Ayca Zeybek", "initials": "AZ"}, {"family": "Sayili", "given": "Dogu", "initials": "D"}, {"family": "Mert", "given": "Olcay", "initials": "O"}, {"family": "Soyturk", "given": "Hakan", "initials": "H"}, {"family": "Gullu", "given": "Seyda", "initials": "S"}, {"family": "Akinturk", "given": "Huseyin", "initials": "H"}, {"family": "Citak", "given": "Erhan", "initials": "E"}, {"family": "Arslan", "given": "Merve", "initials": "M"}, {"family": "Taskinarda", "given": "Melda Guray", "initials": "MG"}, {"family": "Tarman", "given": "Ibrahim Oguzhan", "initials": "IO"}, {"family": "Altun", "given": "Gizem Yilmazer", "initials": "GY"}, {"family": "Ozer", "given": "Ceren", "initials": "C"}, {"family": "Orkut", "given": "Ridvan", "initials": "R"}, {"family": "Demirtas", "given": "Aysegul", "initials": "A"}, {"family": "Tilmensagir", "given": "Idil", "initials": "I"}, {"family": "Keles", "given": "Umur", "initials": "U"}, {"family": "Ulker", "given": "Ceren", "initials": "C"}, {"family": "Aralan", "given": "Gizem", "initials": "G"}, {"family": "Mercan", "given": "Yavuz", "initials": "Y"}, {"family": "Ozkan", "given": "Muge", "initials": "M"}, {"family": "Caglar", "given": "Hasan Onur", "initials": "HO"}, {"family": "Arik", "given": "Gizem", "initials": "G"}, {"family": "Ucar", "given": "Mehmet Can", "initials": "MC"}, {"family": "Yildirim", "given": "Muzaffer", "initials": "M"}, {"family": "Yildirim", "given": "Tugce Canavar", "initials": "TC"}, {"family": "Karadag", "given": "Dilara", "initials": "D"}, {"family": "Bal", "given": "Erhan", "initials": "E"}, {"family": "Erdogan", "given": "Aybike", "initials": "A"}, {"family": "Senturk", "given": "Serif", "initials": "S"}, {"family": "Uzar", "given": "Serdar", "initials": "S"}, {"family": "Enul", "given": "Hakan", "initials": "H"}, {"family": "Adiay", "given": "Cumhur", "initials": "C"}, {"family": "Sarac", "given": "Fahriye", "initials": "F"}, {"family": "Ekiz", "given": "Arzu Tas", "initials": "AT"}, {"family": "Abaci", "given": "Irem", "initials": "I"}, {"family": "Aksoy", "given": "Ozge", "initials": "O"}, {"family": "Polat", "given": "Hivda Ulbegi", "initials": "HU"}, {"family": "Tekin", "given": "Saban", "initials": "S"}, {"family": "Dimitrov", "given": "Stefan", "initials": "S"}, {"family": "Ozkul", "given": "Aykut", "initials": "A"}, {"family": "Wingender", "given": "Gerhard", "initials": "G"}, {"family": "Gursel", "given": "Ihsan", "initials": "I"}, {"family": "Ozturk", "given": "Mehmet", "initials": "M"}, {"family": "Inan", "given": "Mehmet", "initials": "M"}], "type": "journal article", "published": "2023-03-30", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "13", "issue": "1", "pages": "5224", "issn-l": "2045-2322"}, "abstract": "Recombinant protein-based SARS-CoV-2 vaccines are needed to fill the vaccine equity gap. Because protein-subunit based vaccines are easier and cheaper to produce and do not require special storage/transportation conditions, they are suitable for low-/middle-income countries. Here, we report our vaccine development studies with the receptor binding domain of the SARS-CoV-2 Delta Plus strain (RBD-DP) which caused increased hospitalizations compared to other variants. First, we expressed RBD-DP in the Pichia pastoris yeast system and upscaled it to a 5-L fermenter for production. After three-step purification, we obtained RBD-DP with > 95% purity from a protein yield of > 1 g/L of supernatant. Several biophysical and biochemical characterizations were performed to confirm its identity, stability, and functionality. Then, it was formulated in different contents with Alum and CpG for mice immunization. After three doses of immunization, IgG titers from sera reached to > 106 and most importantly it showed high T-cell responses which are required for an effective vaccine to prevent severe COVID-19 disease. A live neutralization test was performed with both the Wuhan strain (B.1.1.7) and Delta strain (B.1.617.2) and it showed high neutralization antibody content for both strains. A challenge study with SARS-CoV-2 infected K18-hACE2 transgenic mice showed good immunoprotective activity with no viruses in the lungs and no lung inflammation for all immunized mice.", "doi": "10.1038/s41598-023-32021-9", "pmid": "36997624", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10062263"}, {"db": "pii", "key": "10.1038/s41598-023-32021-9"}], "notes": [], "created": "2023-04-21T15:51:40.550Z", "modified": "2023-04-21T15:51:40.564Z"}, {"entity": "publication", "iuid": "3879a05a22354ef2a29861a97ec1b3aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3879a05a22354ef2a29861a97ec1b3aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3879a05a22354ef2a29861a97ec1b3aa"}}, "title": "Long-COVID fatigue is not predicted by pre-pandemic plasma IL-6 levels in mild COVID-19.", "authors": [{"family": "Freidin", "given": "Maxim B", "initials": "MB"}, {"family": "Cheetham", "given": "Nathan", "initials": "N"}, {"family": "Duncan", "given": "Emma L", "initials": "EL"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Doores", "given": "Katherine J", "initials": "KJ"}, {"family": "Malim", "given": "Michael H", "initials": "MH"}, {"family": "Rossi", "given": "Niccolo", "initials": "N"}, {"family": "Lord", "given": "Janet M", "initials": "JM"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Borsini", "given": "Alessandra", "initials": "A"}, {"family": "Granville Smith", "given": "Isabelle", "initials": "I"}, {"family": "Falchi", "given": "Mario", "initials": "M"}, {"family": "Pariante", "given": "Carmine", "initials": "C"}, {"family": "Williams", "given": "Frances M K", "initials": "FMK"}], "type": "journal article", "published": "2023-03-30", "journal": {"title": "Inflamm Res", "issn": "1420-908X", "pages": "1-7", "issn-l": null}, "abstract": "Fatigue is a prominent symptom in the general population and may follow viral infection, including SARS-CoV2 infection which causes COVID-19. Chronic fatigue lasting more than three months is the major symptom of the post-COVID syndrome (known colloquially as long-COVID). The mechanisms underlying long-COVID fatigue are unknown. We hypothesized that the development of long-COVID chronic fatigue is driven by the pro-inflammatory immune status of an individual prior to COVID-19.\n\nWe analyzed pre-pandemic plasma levels of IL-6, which plays a key role in persistent fatigue, in N = 1274 community dwelling adults from TwinsUK. Subsequent COVID-19-positive and -negative participants were categorized based on SARS-CoV-2 antigen and antibody testing. Chronic fatigue was assessed using the Chalder Fatigue Scale.\n\nCOVID-19-positive participants exhibited mild disease. Chronic fatigue was a prevalent symptom among this population and significantly higher in positive vs. negative participants (17% vs 11%, respectively; p = 0.001). The qualitative nature of chronic fatigue as determined by individual questionnaire responses was similar in positive and negative participants. Pre-pandemic plasma IL-6 levels were positively associated with chronic fatigue in negative, but not positive individuals. Raised BMI was associated with chronic fatigue in positive participants.\n\nPre-existing increased IL-6 levels may contribute to chronic fatigue symptoms, but there was no increased risk in individuals with mild COVID-19 compared with uninfected individuals. Elevated BMI also increased the risk of chronic fatigue in mild COVID-19, consistent with previous reports.", "doi": "10.1007/s00011-023-01722-2", "pmid": "36995412", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC10062244"}, {"db": "pii", "key": "10.1007/s00011-023-01722-2"}], "notes": [], "created": "2023-04-21T15:53:33.264Z", "modified": "2023-04-21T15:53:33.267Z"}, {"entity": "publication", "iuid": "0922dd1fd6c24abeab55bc0f7ba26b71", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0922dd1fd6c24abeab55bc0f7ba26b71.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0922dd1fd6c24abeab55bc0f7ba26b71"}}, "title": "Gambling and COVID-19: Swedish national gambling data from a state-owned gambling sports and casino operator.", "authors": [{"family": "Balem", "given": "Marianne", "initials": "M", "orcid": "0000-0002-0324-9579", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0413ef1f13d641c98a0de555c4aad642.json"}}, {"family": "Karlsson", "given": "Anna", "initials": "A", "orcid": "0000-0003-1131-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64c210d9f92940ca9860021e69e56a0b.json"}}, {"family": "Widinghoff", "given": "Carolina", "initials": "C", "orcid": "0000-0002-7810-7065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0a6a5a969444d7b8d27a30090c3216e.json"}}, {"family": "Perrot", "given": "Bastien", "initials": "B", "orcid": "0000-0002-3701-6693", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33acfaa75f8549998703777c8269dcf9.json"}}, {"family": "Challet-Bouju", "given": "Ga\u00eblle", "initials": "G", "orcid": "0000-0002-2238-8005", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8363420fee0d48d294ee8e182fe15b08.json"}}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A", "orcid": "0000-0002-5800-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec14ecdcc0654d8ea864f64ce195752b.json"}}], "type": "journal article", "published": "2023-03-30", "journal": {"title": "J Behav Addict", "issn": "2063-5303", "volume": "12", "issue": "1", "pages": "230-241", "issn-l": null}, "abstract": "The lockdown of sports and gambling venues during the coronavirus disease 2019 (COVID-19) pandemic caused a fear of increased gambling on other online gambling types, with a risk for transfer to more addictive gambling than otherwise. This study aimed to estimate changes in gambling activity during COVID-19-affected periods among all gamblers at a Swedish state-owned gambling operator and to analyse observable sex differences.\n\nThis study included gambling tracking data from the Swedish state-owned gambling operator Svenska Spel Sports & Casino (sports betting, online bingo, casino and poker). All individuals (n = 616,245) who gambled at least once from February 10 to July 19, 2020, were included. The study period was divided into four periods according to their expected level of COVID-19 impact on gambling opportunities: one pre-COVID period and three COVID-affected periods (sports cancellation, emerging return of sports, substantial return of sports).\n\nSports betting experienced an apparent decrease, followed by a gradual normalization and an end level substantially below prepandemic levels. For online bingo, gambling levels increased upon sports interruption and then decreased with the return to normality in sports events but remained higher than baseline levels. We observed a similar trend for online poker during the interruption of sports, but with a lower level than baseline levels when sports events normalized. We noticed a trend favouring online casinos during the sports interruption period regarding gambling intensity but not wagering levels.\n\nDramatic changes in the content of the gambling market may divert some gamblers to other gambling types, but maintained effects could not be demonstrated.", "doi": "10.1556/2006.2022.00089", "pmid": "36995980", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-04-21T15:51:54.771Z", "modified": "2023-04-21T15:51:54.989Z"}, {"entity": "publication", "iuid": "fade921f5e854a09b10132d514e27337", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fade921f5e854a09b10132d514e27337.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fade921f5e854a09b10132d514e27337"}}, "title": "The European landscape on allogeneic haematopoeietic cell transplantation in Chronic Lymphocytic Leukaemia between 2009 and 2019: a perspective from the Chronic Malignancies Working Party of the EBMT.", "authors": [{"family": "Tournilhac", "given": "Olivier", "initials": "O", "orcid": "0000-0002-9438-621X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c13ba4e40e4d4297b137a29cddf780f9.json"}}, {"family": "van Gelder", "given": "Michel", "initials": "M"}, {"family": "Eikema", "given": "Dirk-Jan", "initials": "DJ"}, {"family": "Zinger", "given": "Nienke", "initials": "N"}, {"family": "Dreger", "given": "Peter", "initials": "P", "orcid": "0000-0002-7429-8570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4433ddd0ffe348e8ad1495e385e3fd1e.json"}}, {"family": "Bornh\u00e4user", "given": "Martin", "initials": "M"}, {"family": "Vucinic", "given": "Vladan", "initials": "V", "orcid": "0000-0002-8398-285X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9afc2198e04b4d299fa45298534a9b44.json"}}, {"family": "Scheid", "given": "Christof", "initials": "C"}, {"family": "Cornelissen", "given": "Jan J", "initials": "JJ"}, {"family": "Schroeder", "given": "Thomas", "initials": "T"}, {"family": "Jindra", "given": "Pavel", "initials": "P", "orcid": "0000-0002-8415-7069", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7602c74632d04b3b98a5bb0d01f61096.json"}}, {"family": "Sengeloev", "given": "Henrik", "initials": "H"}, {"family": "Nguyen Quoc", "given": "Stephanie", "initials": "S"}, {"family": "Stelljes", "given": "Matthias", "initials": "M"}, {"family": "Blau", "given": "Igor Wolfgang", "initials": "IW"}, {"family": "Mayer", "given": "Jiri", "initials": "J"}, {"family": "Paneesha", "given": "Shankara", "initials": "S"}, {"family": "Chevallier", "given": "Patrice", "initials": "P", "orcid": "0000-0003-3142-5581", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3232eb710cb4a7bb240a5d54f4ef0c8.json"}}, {"family": "Forcade", "given": "Edouard", "initials": "E", "orcid": "0000-0002-8873-2868", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0bfa707a1104de1a132b827238179d4.json"}}, {"family": "Kr\u00f6ger", "given": "Nicolaus", "initials": "N", "orcid": "0000-0001-5103-9966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bcb76aaf69944eb90bff4dce6a4a29f.json"}}, {"family": "Blaise", "given": "Didier", "initials": "D", "orcid": "0000-0002-5684-9447", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09938f98a7bb4e059076c31cb25eabc5.json"}}, {"family": "Gribben", "given": "John", "initials": "J", "orcid": "0000-0002-8505-7430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c243d093ea4a46e68e7d5c1dd052f1b6.json"}}, {"family": "Nielsen", "given": "Bendt", "initials": "B"}, {"family": "Johansson", "given": "Jan-Erik", "initials": "JE"}, {"family": "Kyriakou", "given": "Charalampia", "initials": "C"}, {"family": "Beguin", "given": "Yves", "initials": "Y"}, {"family": "Pioltelli", "given": "Pietro", "initials": "P"}, {"family": "Sampol", "given": "Ant\u00f2nia", "initials": "A", "orcid": "0000-0001-7465-6203", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0345dd93a2514536b82d3c8da6ef87fb.json"}}, {"family": "McLornan", "given": "Donal P", "initials": "DP", "orcid": "0000-0003-1224-091X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c485d00a7f041a184e6863d5d88e4cc.json"}}, {"family": "Schetelig", "given": "Johannes", "initials": "J"}, {"family": "Hayden", "given": "Patrick J", "initials": "PJ", "orcid": "0000-0003-1374-4503", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7cc7cb029ae44d8289498fd80acb6831.json"}}, {"family": "Yakoub-Agha", "given": "Ibrahim", "initials": "I", "orcid": "0000-0003-4524-8782", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/555e2c08de5347fa8ded53ef415ad9d1.json"}}], "type": "journal article", "published": "2023-03-28", "journal": {"title": "Bone Marrow Transplant", "issn": "1476-5365", "pages": "1-4", "issn-l": "0268-3369"}, "abstract": "Allogeneic transplantation (allo-HCT) is a curative treatment in CLL whose efficacy including the most severe forms had led to the 2006 EBMT recommendations. The advent after 2014 of targeted therapies has revolutionized CLL management, allowing prolonged control to patients who have failed immunochemotherapy and/or have TP53 alterations. We analysed the pre COVID pandemic 2009-2019 EBMT registry. The yearly number of allo-HCT raised to 458 in 2011 yet dropped from 2013 onwards to an apparent plateau above 100. Within the 10 countries who were under the EMA for drug approval and performed 83.5% of those procedures, large initial differences were found but the annual number converged to 2-3 per 10 million inhabitants during the 3 most recent years suggesting that allo-HCT remains applied in selected patients. Long-term follow-up on targeted therapies shows that most patients relapse, some early, with risk factors and resistance mechanisms being described. The treatment of patients exposed to both BCL2 and BTK inhibitors and especially those with double refractory disease will become a challenge in which allo-HCT remains a solid option in competition with emerging therapies that have yet to demonstrate their long-term effectiveness.", "doi": "10.1038/s41409-023-01955-z", "pmid": "36977926", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10044103"}, {"db": "pii", "key": "10.1038/s41409-023-01955-z"}], "notes": [], "created": "2023-04-21T15:58:41.357Z", "modified": "2023-04-21T15:58:52.731Z"}, {"entity": "publication", "iuid": "570b29c77de54cf882aad5ca3c22eb43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/570b29c77de54cf882aad5ca3c22eb43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/570b29c77de54cf882aad5ca3c22eb43"}}, "title": "Medical Applications of Nonadditive Entropies.", "authors": [{"family": "Tsallis", "given": "Constantino", "initials": "C", "orcid": "0000-0002-9387-9194", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89cbe0c088dc48f69f0339c432b01c29.json"}}, {"family": "Pasechnik", "given": "Roman", "initials": "R", "orcid": "0000-0003-4231-0149", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce22e54b098840a98f8f0bfafc3f1759.json"}}], "type": "journal article", "published": "2023-03-28", "journal": {"title": "Entropy (Basel)", "issn": "1099-4300", "issn-l": null, "volume": "25", "issue": "4", "pages": null}, "abstract": "The Boltzmann-Gibbs additive entropy SBG=-k\u2211ipilnpi and associated statistical mechanics were generalized in 1988 into nonadditive entropy Sq=k1-\u2211ipiqq-1 and nonextensive statistical mechanics, respectively. Since then, a plethora of medical applications have emerged. In the present review, we illustrate them by briefly presenting image and signal processings, tissue radiation responses, and modeling of disease kinetics, such as for the COVID-19 pandemic.", "doi": "10.3390/e25040578", "pmid": "37190366", "labels": {"Type: Review": null, "Category: Imaging": null}, "xrefs": [{"db": "pmc", "key": "PMC10137456"}, {"db": "pii", "key": "e25040578"}], "notes": [], "created": "2023-10-04T05:11:56.921Z", "modified": "2023-10-04T07:23:35.843Z"}, {"entity": "publication", "iuid": "9a7a008ce380464d8e01b86a3fe63a4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9a7a008ce380464d8e01b86a3fe63a4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9a7a008ce380464d8e01b86a3fe63a4c"}}, "title": "A Case Series on Pregnant Patients with Mild Covid-19 Infection and Signs of Severe Placental Insufficiency.", "authors": [{"family": "Ivert", "given": "A", "initials": "A", "orcid": "0000-0002-3739-1725", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ced16f5a5ab24db6aa5aec2b2c9c12f6.json"}}, {"family": "Lindblad Wollmann", "given": "C", "initials": "C"}, {"family": "Pettersson", "given": "K", "initials": "K"}], "type": "case reports", "published": "2023-03-28", "journal": {"title": "Case Rep Obstet Gynecol", "issn": "2090-6684", "volume": "2023", "pages": "2018551", "issn-l": null}, "abstract": "In this case series, we present five cases of pregnant women who sought medical attention for reduced fetal movements with an ongoing mild maternal Covid-19 infection at a Stockholm hospital in Spring of 2021. At the time of admission, the patients were in gestational week between 24 + 0 and 33 + 5. Abdominal ultrasound at the hospital showed no fetal movements, and cardiotocography (CTG) was pathological. All women delivered via cesarean section within 24 hours after admission. Placental pathology in all cases showed massive perivillous fibrin deposition and extensive histiocytic intervillositis. All placentas were Covid-19 polymerase chain reaction (PCR) positive. The infants were Covid-19 PCR negative. Consistent with other published case reports, we hypothesize that Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect the placenta resulting in massive perivillous fibrin deposition and histiocytic intervillositis leading to acute placental insufficiency and fetal hypoxia. The absence of intrauterine growth restriction also augments the theory of an acute onset of placental insufficiency due to the Covid-19 infection.", "doi": "10.1155/2023/2018551", "pmid": "37025388", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10072962"}], "notes": [], "created": "2023-04-20T17:30:38.579Z", "modified": "2023-04-20T17:30:38.645Z"}, {"entity": "publication", "iuid": "8cb3831d70fc4818aea5cee4def8092f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8cb3831d70fc4818aea5cee4def8092f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8cb3831d70fc4818aea5cee4def8092f"}}, "title": "Sexual and reproductive health in Britain during the first year of the COVID-19 pandemic: cross-sectional population survey (Natsal-COVID-Wave 2) and national surveillance data.", "authors": [{"family": "Mitchell", "given": "Kirstin R", "initials": "KR", "orcid": "0000-0002-4409-6601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2af6a4b606314786806e669e86b92ee0.json"}}, {"family": "Willis", "given": "Malachi", "initials": "M", "orcid": "0000-0002-3173-3990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ca9dea31fdbd4c4db30607d7f3b274fd.json"}}, {"family": "Dema", "given": "Emily", "initials": "E", "orcid": "0000-0002-7254-2023", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3843a1be6fc4e37ac3f8eeff9a2bbb2.json"}}, {"family": "Baxter", "given": "Andrew J", "initials": "AJ", "orcid": "0000-0002-7654-9687", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9814cc9ab7534effba5c569aab450cc4.json"}}, {"family": "Connolly", "given": "Anne", "initials": "A", "orcid": "0000-0003-4953-2182", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65548be760514e228167f010b442043d.json"}}, {"family": "Riddell", "given": "Julie", "initials": "J", "orcid": "0000-0002-8084-4566", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9660f5597db42d19462b83c9f8a1be4.json"}}, {"family": "Bos\u00f3 P\u00e9rez", "given": "Raquel", "initials": "R", "orcid": "0000-0001-7342-4566", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3d61e70a5874b4ea43a1d9d73333605.json"}}, {"family": "Clifton", "given": "Soazig", "initials": "S", "orcid": "0000-0002-4171-0805", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7cea96a2c56409dab9f474144303c30.json"}}, {"family": "Gibbs", "given": "Jo", "initials": "J", "orcid": "0000-0001-5696-0260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8e88ce8b71e4ae3b03749616b5a9eab.json"}}, {"family": "Tanton", "given": "Clare", "initials": "C", "orcid": "0000-0002-4612-1858", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adf2ed41e93f422aa32a1afe93895bed.json"}}, {"family": "Geary", "given": "Rebecca", "initials": "R", "orcid": "0000-0003-1417-1057", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a696d4c9c6024ce58dbcc443326bf362.json"}}, {"family": "Ratna", "given": "Natasha", "initials": "N", "orcid": "0000-0002-8848-7938", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1913b5456b1044e4a0c3f93aa7405fa7.json"}}, {"family": "Mohammed", "given": "Hamish", "initials": "H", "orcid": "0000-0002-2060-7286", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54be4ca28b4b44f7939f51de5f34077c.json"}}, {"family": "Unemo", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1710-2081", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed8c616c8c16456590342443393553cb.json"}}, {"family": "Bonell", "given": "Christopher", "initials": "C", "orcid": "0000-0002-6253-6498", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eeec7c46459414a974c9f42cc3b2baa.json"}}, {"family": "Copas", "given": "Andrew", "initials": "A", "orcid": "0000-0001-8968-5963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0aee9dde1bb2497398a63252a713c88a.json"}}, {"family": "Sonnenberg", "given": "Pam", "initials": "P", "orcid": "0000-0002-1067-1583", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/703eb395b191407eb977ed908453cb30.json"}}, {"family": "Mercer", "given": "Catherine H", "initials": "CH", "orcid": "0000-0002-4220-5034", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6332e0448a8b49c7ab019b7c75768df1.json"}}, {"family": "Field", "given": "Nigel", "initials": "N", "orcid": "0000-0002-2825-6652", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a84330facf864cfe9a4a51550cea9543.json"}}], "type": "journal article", "published": "2023-03-27", "journal": {"title": "Sex Transm Infect", "issn": "1472-3263", "issn-l": "1368-4973"}, "abstract": "To assess sexual behaviour, and sexual and reproductive health (SRH) outcomes, after 1 year of the COVID-19 pandemic in Britain.\n\n6658 participants aged 18-59 and resident in Britain completed a cross-sectional web-panel survey (Natsal-COVID-Wave 2, March-April 2021), 1 year after the first lockdown. Natsal-COVID-2 follows the Natsal-COVID-Wave 1 survey (July-August 2020) which captured impacts in the initial months. Quota-based sampling and weighting resulted in a quasi-representative population sample. Data were contextualised with reference to the most recent probability sample population data (Natsal-3; collected 2010-12; 15 162 participants aged 16-74) and national surveillance data on recorded sexually transmitted infection (STI) testing, conceptions, and abortions in England/Wales (2010-2020). The main outcomes were: sexual behaviour; SRH service use; pregnancy, abortion and fertility management; sexual dissatisfaction, distress and difficulties.\n\nIn the year from the first lockdown, over two-thirds of participants reported one or more sexual partners (women 71.8%; men 69.9%), while fewer than 20.0% reported a new partner (women 10.4%; men 16.8%). Median occasions of sex per month was two. Compared with 2010-12 (Natsal-3), we found less sexual risk behaviour (lower reporting of multiple partners, new partners, and new condomless partners), including among younger participants and those reporting same-sex behaviour. One in 10 women reported a pregnancy; pregnancies were fewer than in 2010-12 and less likely to be scored as unplanned. 19.3% of women and 22.8% of men were distressed or worried about their sex life, significantly more than in 2010-12. Compared with surveillance trends from 2010 to 2019, we found lower than expected use of STI-related services and HIV testing, lower levels of chlamydia testing, and fewer conceptions and abortions.\n\nOur findings are consistent with significant changes in sexual behaviour, SRH, and service uptake in the year following the first lockdown in Britain. These data are foundational to SRH recovery and policy planning.", "doi": "10.1136/sextrans-2022-055680", "pmid": "36973042", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "sextrans-2022-055680"}], "notes": [], "created": "2023-04-21T15:59:49.563Z", "modified": "2023-04-21T15:59:49.823Z"}, {"entity": "publication", "iuid": "a074c5ca733b4ae4896ac4c4e4adb77a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a074c5ca733b4ae4896ac4c4e4adb77a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a074c5ca733b4ae4896ac4c4e4adb77a"}}, "title": "Proteomic characteristics and diagnostic potential of exhaled breath particles in patients with COVID-19.", "authors": [{"family": "Hirdman", "given": "Gabriel", "initials": "G"}, {"family": "Bod\u00e9n", "given": "Embla", "initials": "E"}, {"family": "Kjellstr\u00f6m", "given": "Sven", "initials": "S"}, {"family": "Fraenkel", "given": "Carl-Johan", "initials": "CJ"}, {"family": "Olm", "given": "Franziska", "initials": "F"}, {"family": "Hallgren", "given": "Oskar", "initials": "O"}, {"family": "Lindstedt", "given": "Sandra", "initials": "S"}], "type": "journal article", "published": "2023-03-27", "journal": {"title": "Clin Proteomics", "issn": "1542-6416", "volume": "20", "issue": "1", "pages": "13", "issn-l": null}, "abstract": "SARS-CoV-2 has been shown to predominantly infect the airways and the respiratory tract and too often have an unpredictable and different pathologic pattern compared to other respiratory diseases. Current clinical diagnostical tools in pulmonary medicine expose patients to harmful radiation, are too unspecific or even invasive. Proteomic analysis of exhaled breath particles (EBPs) in contrast, are non-invasive, sample directly from the pathological source and presents as a novel explorative and diagnostical tool.\n\nPatients with PCR-verified COVID-19 infection (COV-POS, n = 20), and patients with respiratory symptoms but with > 2 negative polymerase chain reaction (PCR) tests (COV-NEG, n = 16) and healthy controls (HCO, n = 12) were prospectively recruited. EBPs were collected using a \"particles in exhaled air\" (PExA 2.0) device. Particle per exhaled volume (PEV) and size distribution profiles were compared. Proteins were analyzed using liquid chromatography-mass spectrometry. A random forest machine learning classification model was then trained and validated on EBP data achieving an accuracy of 0.92.\n\nSignificant increases in PEV and changes in size distribution profiles of EBPs was seen in COV-POS and COV-NEG compared to healthy controls. We achieved a deep proteome profiling of EBP across the three groups with proteins involved in immune activation, acute phase response, cell adhesion, blood coagulation, and known components of the respiratory tract lining fluid, among others. We demonstrated promising results for the use of an integrated EBP biomarker panel together with particle concentration for diagnosis of COVID-19 as well as a robust method for protein identification in EBPs.\n\nOur results demonstrate the promising potential for the use of EBP fingerprints in biomarker discovery and for diagnosing pulmonary diseases, rapidly and non-invasively with minimal patient discomfort.", "doi": "10.1186/s12014-023-09403-2", "pmid": "36967377", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10040313"}, {"db": "pii", "key": "10.1186/s12014-023-09403-2"}], "notes": [], "created": "2023-04-21T16:02:51.349Z", "modified": "2023-04-21T16:03:10.432Z"}, {"entity": "publication", "iuid": "d6b973d57dd049d3a1c9caa7041b4b4f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d6b973d57dd049d3a1c9caa7041b4b4f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d6b973d57dd049d3a1c9caa7041b4b4f"}}, "title": "Flares in autoimmune rheumatic diseases in the post-COVID-19 vaccination period - A Cross-sequential study based on COVAD surveys.", "authors": [{"family": "Jagtap", "given": "Kshitij", "initials": "K", "orcid": "0000-0003-2729-737X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822b9da98e5d4eb2975ff97fe484933f.json"}}, {"family": "R", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Vaidya", "given": "Binit", "initials": "B", "orcid": "0000-0002-4840-8924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b2296d53fe14fc7a8415f26e03e1944.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-0986-8354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2e6226ae5e7427fbf52e180dd14e28f.json"}}, {"family": "Saha", "given": "Sreoshy", "initials": "S", "orcid": "0000-0001-6745-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00238845dd4833ae51ffb75e2fe144.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Edgar Gracia-Ramos", "given": "Abraham", "initials": "A", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}, {"family": "Patel", "given": "Aarat", "initials": "A"}, {"family": "Pauling", "given": "John D", "initials": "JD", "orcid": "0000-0002-2793-2364", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e37709273d404d17a88c7c850777b99f.json"}}, {"family": "Wincup", "given": "Chris", "initials": "C", "orcid": "0000-0002-8742-8311", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a674f02e7f7f45f58167eb24f81502f3.json"}}, {"family": "Barman", "given": "Bhupen", "initials": "B", "orcid": "0000-0002-5433-1310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7747785ec5fa4743bc70bd20fbca10fd.json"}}, {"family": "Zamora Tehozol", "given": "Erick Adrian", "initials": "EA", "orcid": "0000-0002-7888-3961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a55c695ac4f4003993a2f511cca7739.json"}}, {"family": "Serrano", "given": "Jorge Rojas", "initials": "JR", "orcid": "0000-0001-6980-7898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/225fd8b396ac40f4a77f1ec229c086b6.json"}}, {"family": "Garc\u00eda-De La Torre", "given": "Ignacio", "initials": "I", "orcid": "0000-0002-9261-678X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/086b85d66fb84b50bd51bbe5a979dfe3.json"}}, {"family": "Colunga-Pedraza", "given": "Iris J", "initials": "IJ", "orcid": "0000-0002-2786-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50e46ef2c7f44b39a1d28fea6a8e621d.json"}}, {"family": "Merayo-Chalico", "given": "Javier", "initials": "J", "orcid": "0000-0002-5870-0523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d74c0ab33cbe4df586e1a1add37d0e65.json"}}, {"family": "Chibuzo", "given": "Okwara Celestine", "initials": "OC", "orcid": "0000-0002-7727-5657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f415c3f3dea49cb90ae12def4278f00.json"}}, {"family": "Katchamart", "given": "Wanruchada", "initials": "W", "orcid": "0000-0002-8952-5967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9439933b38fb49aca8fdbb5038ff603c.json"}}, {"family": "Goo", "given": "Phonpen Akawatcharangura", "initials": "PA"}, {"family": "Shumnalieva", "given": "Russka", "initials": "R", "orcid": "0000-0003-2321-6536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/933232cd7feb48ee81b5971f01f52e23.json"}}, {"family": "Chen", "given": "Yi-Ming", "initials": "YM", "orcid": "0000-0001-7593-3065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/795f1bf1d4824521a3301f7c50f62bc4.json"}}, {"family": "Hoff", "given": "Leonardo Santos", "initials": "LS", "orcid": "0000-0002-2083-4796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1df7af8caf024ca39c57278fdf18c766.json"}}, {"family": "El Kibbi", "given": "Lina", "initials": "L", "orcid": "0000-0003-1710-9996", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11bb4fc524264c6897dec9642a0ef7cd.json"}}, {"family": "Halabi", "given": "Hussein", "initials": "H", "orcid": "0000-0002-5174-8292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb337090a5ab4461a07e8620bee1b4b9.json"}}, {"family": "Sazliyana Shaharir", "given": "Syahrul", "initials": "S", "orcid": "0000-0002-9068-8114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1e6310979d44d58b548c61c733412af.json"}}, {"family": "Hasan", "given": "A T M Tanveer", "initials": "ATMT", "orcid": "0000-0002-5332-3319", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ffdb3329292438fac4005923ee79012.json"}}, {"family": "Dey", "given": "Dzifa", "initials": "D", "orcid": "0000-0002-3339-5112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2615e43aeba34a0585679bdd14a1a324.json"}}, {"family": "Guti\u00e9rrez", "given": "Carlos Enrique Toro", "initials": "CET", "orcid": "0000-0002-6084-7049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/980e455c5d114caaaefb6e0b55eaa3b3.json"}}, {"family": "Caballero-Uribe", "given": "Carlo Vinicio", "initials": "CV", "orcid": "0000-0002-9845-8620", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42d86c9923424f9a804bab4580b993c3.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "COVAD study group", "given": "", "initials": ""}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}], "type": "journal article", "published": "2023-03-24", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "issn-l": null}, "abstract": "Flares of autoimmune rheumatic disease (AIRDs) following COVID-19 vaccination are an outstanding concern in vaccine-hesitant individuals. Therefore, we investigated the incidence, predictors and patterns of flares following vaccination in individuals living with AIRDs using global COVID-19 Vaccination in Autoimmune Diseases (COVAD) surveys.\n\nThe COVAD surveys were used to extract data on flare demographics, comorbidities, COVID-19 history, and vaccination details among patients with AIRDs. Flares following vaccination were identified as patient-reported(a), increased immunosuppression(b), clinical exacerbations(c) and worsening of PROMIS scores(d). We studied flare characteristics and used regression models to differentiate flares among various AIRDs.\n\nOf 15165 total responses, the incidence of flares in 3453 patients with AIRDs was 11.3%, 14.8%, 9.5%, and 26.7% by definitions a-d, respectively. There was moderate agreement between patient-reported and immunosuppression-defined flares (K = 0.403, p = 0.022). Arthritis (61.6%) and fatigue (58.8%) were the most commonly reported symptoms. Self-reported flares were associated with higher comorbidities (p = 0.013), mental health disorders (MHD) (p < 0.001), and autoimmune multimorbidity (AIDm) (p < 0.001).In regression analysis, the presence of AIDm (OR = 1.4;95%CI:1.1-1.7;p=0.003), MHD (OR = 1.7;95%CI:1.1-2.6;p=0.007), and Moderna vaccine (OR = 1.5;95%CI:1.09-2.2;p=0.014) recipients were predictors of flares. Mycophenolate (OR = 0.5;95%CI:0.3-0.8;p=0.009) and glucocorticoids (OR = 0.6;95%CI:0.5-0.8;p=0.003) were protective.A higher frequency of patients with AIRDs reported overall active disease post-vaccination compared to before vaccination (OR = 1.3;95%CI:1.1-1.5;p<0.001).\n\nFlares occur in nearly one in ten individuals with AIRDs after COVID vaccination, with people with comorbidities, especially AID multimorbidity, mental health disorders and use of the Moderna vaccine being particularly vulnerable. Future avenues include exploring flare profiles and optimizing vaccine strategies for this group.", "doi": "10.1093/rheumatology/kead144", "pmid": "36961331", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7085591"}], "notes": [], "created": "2023-04-21T16:03:32.208Z", "modified": "2023-04-21T16:03:32.559Z"}, {"entity": "publication", "iuid": "86e00e5653a54fabbc9a2f6decb2ad37", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86e00e5653a54fabbc9a2f6decb2ad37.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86e00e5653a54fabbc9a2f6decb2ad37"}}, "title": "Syndemic health crises-The growing role of National Public Health Institutes in shaping a coordinated response.", "authors": [{"family": "Tweed", "given": "Sam", "initials": "S", "orcid": "0000-0002-6395-8422", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f2abaf594474ad5a8c3a79edd012803.json"}}, {"family": "Selbie", "given": "Duncan", "initials": "D"}, {"family": "Tegnell", "given": "Anders", "initials": "A"}, {"family": "Viso", "given": "Anne-Catherine", "initials": "AC"}, {"family": "Ahmed", "given": "Abdifatah", "initials": "A"}, {"family": "Mastkov", "given": "Oleksandr", "initials": "O"}, {"family": "Pendergast", "given": "Scott", "initials": "S"}, {"family": "Squires", "given": "Neil", "initials": "N"}], "type": "journal article", "published": "2023-03-23", "journal": {"title": "Int J Health Plann Manage", "issn": "1099-1751", "issn-l": null}, "abstract": "Countries across the world are experiencing syndemic health crises where infectious pathogens including COVID-19 interact with epidemics of communicable and non-communicable diseases. Combined with war, environmental instability and the effects of soaring inflation, a public health crisis has emerged requiring an integrated response. Increasingly, national public health institutes (NPHIs) are at the forefront of leading this, as demonstrated at the 2022 Annual Meeting of the International Association of National Public Health Institutes (IANPHI). These effects are particularly evident where conflict is exacerbating health crises in Ukraine and Somalia. In Ukraine, medical and public health workers have been killed and infrastructure destroyed, which require major efforts to rebuild to international standards. In Somalia, these crises are magnified by the effects of climate change, leading to greater food insecurity, heat-related deaths and famine. National public health institutes are crucial in these contexts and many others to support integrated political responses where health challenges span local, national and international levels and involve multiple stakeholders. This can be seen in strengthening of Integrated Disease Surveillance and work towards the Sustainable Development Goals. National public health institutes also provide integration through the international system, working jointly to build national capacities to deliver essential public health functions. In this context, the 2022 IANPHI Annual meeting agreed the Stockholm Statement, highlighting the role that NPHIs play in tackling the causes and effects of interconnected global and local challenges to public health. This represents an important step in addressing complex health crises and syndemics which require whole-of-society responses, with NPHIs uniquely placed to work across sectors and provide system leadership in response.", "doi": "10.1002/hpm.3634", "pmid": "36959725", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-04-21T16:05:09.001Z", "modified": "2023-04-21T16:05:09.062Z"}, {"entity": "publication", "iuid": "2e4797c19d1e4d4ea6981a7c30418394", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e4797c19d1e4d4ea6981a7c30418394.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e4797c19d1e4d4ea6981a7c30418394"}}, "title": "Involuntary Resistance.", "authors": [{"family": "Baaz", "given": "Mikael", "initials": "M"}, {"family": "Lilja", "given": "Mona", "initials": "M", "orcid": "0000-0003-2773-8534", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9bb2b4cd78b74bab81987a2d1c2ab943.json"}}, {"family": "Wallgren", "given": "Malin", "initials": "M"}], "type": "journal article", "published": "2023-03-23", "journal": {"title": "Int J Polit Cult Soc", "issn": "0891-4486", "issn-l": null, "volume": null, "issue": null, "pages": "1-21"}, "abstract": "This paper problematizes the notion of \"intent\" through the concept of \"involuntary resistance\". Departing from the narratives of employees in nursing homes in Sweden during the Covid-19 pandemic in 2020 and 2021, we suggest that neoliberal norms and a local management that capitalizes on social hierarchies (sex, age, class, etc.) were the context of the strong biopolitical state management that occurred due to the Covid-19 pandemic. The friction between different forms of governing became a seedbed for an involuntary resistance with an unclear intent against the state recommendations. This sheds light upon the need to (re)frame the current dominance of specific types of knowledge that are constructed in the field of resistance. We suggest that new paths of thought are needed-within social sciences-that work towards a wider conceptualizing of resistance, which embraces practices that lie outside the common thought of dissent.", "doi": "10.1007/s10767-023-09442-5", "pmid": "37361706", "labels": {"Category: Social Science & Humanities": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC10034246"}, {"db": "pii", "key": "9442"}], "notes": [], "created": "2023-10-04T09:31:43.756Z", "modified": "2023-10-04T10:52:59.715Z"}, {"entity": "publication", "iuid": "b3ca239b5db743f2a50b5cd6f7e41585", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b3ca239b5db743f2a50b5cd6f7e41585.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b3ca239b5db743f2a50b5cd6f7e41585"}}, "title": "Community participatory learning and action cycle groups to reduce type 2 diabetes in Bangladesh (D:Clare): an updated study protocol for a parallel arm cluster randomised controlled trial.", "authors": [{"family": "King", "given": "Carina", "initials": "C"}, {"family": "Pires", "given": "Malini", "initials": "M"}, {"family": "Ahmed", "given": "Naveed", "initials": "N"}, {"family": "Akter", "given": "Kohenour", "initials": "K"}, {"family": "Kuddus", "given": "Abdul", "initials": "A"}, {"family": "Copas", "given": "Andrew", "initials": "A"}, {"family": "Haghparast-Bidgoli", "given": "Hassan", "initials": "H"}, {"family": "Morrison", "given": "Joanna", "initials": "J"}, {"family": "Nahar", "given": "Tasmin", "initials": "T"}, {"family": "Shaha", "given": "Sanjit Kumer", "initials": "SK"}, {"family": "Khan", "given": "AKAzad", "initials": "A"}, {"family": "Azad", "given": "Kishwar", "initials": "K"}, {"family": "Fottrell", "given": "Edward", "initials": "E", "orcid": "0000-0003-0518-7161", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb5f48cd80b4425984648f889a2a2b45.json"}}], "type": "clinical trial protocol", "published": "2023-03-23", "journal": {"title": "Trials", "issn": "1745-6215", "volume": "24", "issue": "1", "pages": "218", "issn-l": null}, "abstract": "The \"Diabetes: Community-led Awareness, Response and Evaluation\" (D:Clare) trial aims to scale up and replicate an evidence-based participatory learning and action cycle intervention in Bangladesh, to inform policy on population-level T2DM prevention and control.The trial was originally designed as a stepped-wedge cluster randomised controlled trial, with the interventions running from March 2020 to September 2022. Twelve clusters were randomly allocated (1:1) to implement the intervention at months 1 or 12 in two steps, and evaluated through three cross-sectional surveys at months 1, 12 and 24. However, due to the COVID-19 pandemic, we suspended project activities on the 20th of March 2020. As a result of the changed risk landscape and the delays introduced by the COVID-19 pandemic, we changed from the stepped-wedge design to a wait-list parallel arm cluster RCT (cRCT) with baseline data. We had four key reasons for eventually agreeing to change designs: equipoise, temporal bias in exposure and outcomes, loss of power and time and funding considerations.Trial registration ISRCTN42219712 . Registered on 31 October 2019.", "doi": "10.1186/s13063-023-07243-x", "pmid": "36959617", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10034243"}, {"db": "pii", "key": "10.1186/s13063-023-07243-x"}], "notes": [], "created": "2023-04-21T16:05:31.152Z", "modified": "2023-04-21T16:05:31.188Z"}, {"entity": "publication", "iuid": "3c95dafecf78407bbfb32294e1d5700e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3c95dafecf78407bbfb32294e1d5700e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3c95dafecf78407bbfb32294e1d5700e"}}, "title": "Health progression for Covid-19 survivors hospitalized in geriatric clinics in Sweden.", "authors": [{"family": "Kananen", "given": "Laura", "initials": "L", "orcid": "0000-0003-3742-8927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d8f660eb3e4490f8d6d2d12b773d92d.json"}}, {"family": "Hong", "given": "Xu", "initials": "X"}, {"family": "Annetorp", "given": "Martin", "initials": "M"}, {"family": "Mak", "given": "Jonathan K L", "initials": "JKL", "orcid": "0000-0003-4454-8580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4ec879e8b4a4879af61239068143893.json"}}, {"family": "Jylh\u00e4v\u00e4", "given": "Juulia", "initials": "J"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}, {"family": "H\u00e4gg", "given": "Sara", "initials": "S"}, {"family": "Religa", "given": "Dorota", "initials": "D"}], "type": "journal article", "published": "2023-03-22", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "18", "issue": "3", "pages": "e0283344", "issn-l": "1932-6203"}, "abstract": "To analyse if the health progression of geriatric Covid-19 survivors three months after an acute Covid-19 infection was worse than in other geriatric patients. Specifically, we wanted to see if we could see distinct health profiles in the flow of re-admitted Covid-19 patients compared to re-admitted non-Covid-19 controls.\n\nMatched cohort study.\n\nElectronic medical records of geriatric patients hospitalised in geriatric clinics in Stockholm, Sweden, between March 2020 and January 2022. Patients readmitted three months after initial admission were selected for the analysis and Covid-19 survivors (n = 895) were compared to age-sex-Charlson comorbidity index (CCI)-matched non-Covid-19 controls (n = 2685).\n\nWe assessed using binary logistic and Cox regression if a previous Covid-19 infection could be a risk factor for worse health progression indicated by the CCI, hospital frailty risk score (HFRS), mortality and specific comorbidities.\n\nThe patients were mostly older than 75 years and, already at baseline, had typically multiple comorbidities. The Covid-19 patients with readmission had mostly had their acute-phase infection in the 1st or 2nd pandemic waves before the vaccinations. The Covid-19 patients did not have worse health after three months compared to the matched controls according to the CCI (odds ratio, OR[95% confidence interval, CI] = 1.12[0.94-1.34]), HFRS (OR[95%CI] = 1.05[0.87-1.26]), 6-months (hazard ratio, HR[95%CI] = 1.04[0.70-1.52]) and 1-year-mortality risk (HR[95%CI] = 0.89[0.71-1.10]), adjusted for age, sex and health at baseline (the CCI and HFRS).\n\nThe overall health progression of re-hospitalized geriatric Covid-19 survivors did not differ dramatically from other re-hospitalized geriatric patients with similar age, sex and health at baseline. Our results emphasize that Covid-19 was especially detrimental for geriatric patients in the acute-phase, but not in the later phase. Further studies including post-vaccination samples are needed.", "doi": "10.1371/journal.pone.0283344", "pmid": "36947542", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10032538"}, {"db": "pii", "key": "PONE-D-22-21870"}], "notes": [], "created": "2023-04-21T16:06:57.286Z", "modified": "2023-04-21T16:06:57.365Z"}, {"entity": "publication", "iuid": "3f8d510834ab41f097f8cfa99a8c238f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f8d510834ab41f097f8cfa99a8c238f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f8d510834ab41f097f8cfa99a8c238f"}}, "title": "Correlates of protection and viral load trajectories in omicron breakthrough infections in triple vaccinated healthcare workers.", "authors": [{"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Norin", "given": "Nina Greilert", "initials": "NG"}, {"family": "Bladh", "given": "Oscar", "initials": "O"}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f2dc27d02294a15a6f691be6aab641f.json"}}, {"family": "Gordon", "given": "Max", "initials": "M", "orcid": "0000-0002-8080-5815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b07b91dec1424185a3e8ee6c8bbf00d7.json"}}, {"family": "Ng", "given": "Henry", "initials": "H"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Phillipson", "given": "Mia", "initials": "M", "orcid": "0000-0002-2387-0266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/614a4a6f69204c6287a81a79a1a7a8f1.json"}}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "Alm", "given": "Jessica J", "initials": "JJ"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2023-03-22", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "1577", "issn-l": "2041-1723"}, "abstract": "Vaccination offers protection against severe COVID-19 caused by SARS-CoV-2 omicron but is less effective against infection. Characteristics such as serum antibody titer correlation to protection, viral abundance and clearance of omicron infection in vaccinated individuals are scarce. We present a 4-week twice-weekly SARS-CoV-2 qPCR screening in 368 triple vaccinated healthcare workers. Spike-specific IgG levels, neutralization titers and mucosal spike-specific IgA-levels were determined at study start and qPCR-positive participants were sampled repeatedly for two weeks. 81 (cumulative incidence 22%) BA.1, BA.1.1 and BA.2 infections were detected. High serum antibody titers are shown to be protective against infection (p < 0.01), linked to reduced viral load (p < 0.01) and time to viral clearance (p < 0.05). Pre-omicron SARS-CoV-2 infection is independently associated to increased protection against omicron, largely mediated by mucosal spike specific IgA responses (nested models lr test p = 0.02 and 0.008). Only 10% of infected participants remain asymptomatic through the course of their infection. We demonstrate that high levels of vaccine-induced spike-specific WT antibodies are linked to increased protection against infection and to reduced viral load if infected, and suggest that the additional protection offered by pre-omicron SARS-CoV-2 infection largely is mediated by mucosal spike-specific IgA.", "doi": "10.1038/s41467-023-36984-1", "pmid": "36949041", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Omicron VoC": null}, "xrefs": [{"db": "pmc", "key": "PMC10031702"}, {"db": "pii", "key": "10.1038/s41467-023-36984-1"}], "notes": [], "created": "2023-04-21T16:06:33.901Z", "modified": "2023-06-19T14:26:54.012Z"}, {"entity": "publication", "iuid": "0f8947530b744d4286909af61fbb33c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0f8947530b744d4286909af61fbb33c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0f8947530b744d4286909af61fbb33c5"}}, "title": "Clinical pathway of COVID-19 patients in primary health care in 30 European countries: Eurodata study.", "authors": [{"family": "Ares-Blanco", "given": "Sara", "initials": "S", "orcid": "0000-0002-4984-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5929b4be5ff946a2af9b33fde3fb09ec.json"}}, {"family": "Guisado-Clavero", "given": "Marina", "initials": "M", "orcid": "0000-0002-8448-2929", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe6cb00ce6e64ea9ae551a4a65c1093c.json"}}, {"family": "Ramos Del Rio", "given": "Lourdes", "initials": "L", "orcid": "0000-0003-4850-2053", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/629e28d8cf1d4ba3926ba037e14f5742.json"}}, {"family": "Gefaell Larrondo", "given": "Ileana", "initials": "I", "orcid": "0000-0002-1635-1003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a6e202b315e4966a1fc58919d4f4e4e.json"}}, {"family": "Fitzgerald", "given": "Louise", "initials": "L", "orcid": "0009-0009-8039-3097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54a11aeb7912445e91a8861314dc9dc3.json"}}, {"family": "Adler", "given": "Limor", "initials": "L", "orcid": "0000-0002-9335-6596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d78ad3257d4a4337b7dcdf9922159290.json"}}, {"family": "Assenova", "given": "Radost", "initials": "R", "orcid": "0000-0003-2158-5792", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ded85b8b782e4e58aef1767e73bd5c8e.json"}}, {"family": "Bakola", "given": "Maria", "initials": "M", "orcid": "0000-0002-9016-9322", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6da94c24ddbe4917aba9f082cc0de1c0.json"}}, {"family": "Bayen", "given": "Sabine", "initials": "S", "orcid": "0000-0002-3334-9394", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/97df8a37f1314326b345c4d55fe81941.json"}}, {"family": "Brutskaya-Stempkovskaya", "given": "Elena", "initials": "E"}, {"family": "Busneag", "given": "Iliana-Carmen", "initials": "IC", "orcid": "0000-0001-5611-4312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/980a841d76cd48ed81d4187314a10e3f.json"}}, {"family": "Domeyer", "given": "Philippe-Richard", "initials": "PR", "orcid": "0000-0003-4594-1202", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/223b4565009340998b3fb347d5d62450.json"}}, {"family": "Gjorgjievski", "given": "Dragan", "initials": "D", "orcid": "0000-0003-1817-7632", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/196c52fd9c7c4214a6ae708ed49aa08e.json"}}, {"family": "Hoffmann", "given": "Kathryn", "initials": "K", "orcid": "0000-0001-8760-4250", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/97efc06959c84715a62389edbb78f5d6.json"}}, {"family": "\u0406\u043b\u044c\u043a\u043e\u0432", "given": "\u041e\u043a\u0441\u0430\u043d\u0430", "initials": "\u041e", "orcid": "0000-0002-0923-0596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3902996bf15440c4b6f9491b17d40e61.json"}}, {"family": "Trifon Karathanos", "given": "Vasilis", "initials": "V"}, {"family": "Kirkovski", "given": "Aleksandar", "initials": "A", "orcid": "0000-0001-9002-7028", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e2e11e53a2444799bb3af8d1c6fd951.json"}}, {"family": "Kne\u017eevi\u0107", "given": "Sne\u017eana", "initials": "S", "orcid": "0000-0001-9137-2122", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d71f49de1734f4cb1d5c8d601d32dec.json"}}, {"family": "\u00c7imen Korkmaz", "given": "B\u00fcsra", "initials": "B", "orcid": "0000-0001-7224-5734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ac217a7408242f7920df89fdc6c053f.json"}}, {"family": "Heleno", "given": "Bruno", "initials": "B", "orcid": "0000-0002-3943-1858", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/298ecb30af3b4dd39acadc195016c729.json"}}, {"family": "Nessler", "given": "Katarzyna", "initials": "K", "orcid": "0000-0001-9869-7923", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b12b696d11b34519b8cb27cd01db009a.json"}}, {"family": "Murauskien\u0117", "given": "Liubov\u0117", "initials": "L", "orcid": "0000-0002-6625-8843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5196c9522ef74c82a5a5efc07196e3e2.json"}}, {"family": "Neves", "given": "Ana Luisa", "initials": "AL", "orcid": "0000-0002-7107-7211", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/313da3100a6143a5bfa50a983b477d59.json"}}, {"family": "Parodi L\u00f3pez", "given": "Naldy", "initials": "N", "orcid": "0000-0001-6367-9389", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf3c3c30eee1498d980d3be9bebd0543.json"}}, {"family": "Perj\u00e9s", "given": "\u00c1bel", "initials": "\u00c1", "orcid": "0000-0002-7176-1275", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7cf2b396ec4430c81bc3f76ac2d070b.json"}}, {"family": "Petek", "given": "Davorina", "initials": "D", "orcid": "0000-0002-0151-4463", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb8c599dfe4a496aa21408f3521ded5e.json"}}, {"family": "Petrazzuoli", "given": "Ferdinando", "initials": "F", "orcid": "0000-0003-1058-492X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50bb7fdd235f46629be48fdff0a5fd6c.json"}}, {"family": "Petricek", "given": "Goranka", "initials": "G", "orcid": "0000-0002-6614-3085", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd2203cac86047658296c405e6173680.json"}}, {"family": "Seifert", "given": "Bohumil", "initials": "B", "orcid": "0000-0002-6881-8840", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64e3433f85084d9499b345eb10e31052.json"}}, {"family": "Serafini", "given": "Alice", "initials": "A", "orcid": "0000-0002-7396-2839", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dfd0165d3afe49f49370124c8a379a81.json"}}, {"family": "Sentker", "given": "Theresa", "initials": "T", "orcid": "0000-0003-1162-310X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bed1b751e47d419fa5c1e86a517a8161.json"}}, {"family": "Tiili", "given": "Paula", "initials": "P", "orcid": "0000-0002-7916-7262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3939d43175b4bddbaf87dea226190fb.json"}}, {"family": "Torzsa", "given": "P\u00e9ter", "initials": "P"}, {"family": "Vaes", "given": "Bert", "initials": "B", "orcid": "0000-0001-5244-1930", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e0e264d183c46d198df84a956aef74f.json"}}, {"family": "van Pottebergh", "given": "Gijs", "initials": "G", "orcid": "0000-0002-4189-3517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c5f6c9a7d294faab488ade63d22a9bb.json"}}, {"family": "Vinker", "given": "Shlomo", "initials": "S", "orcid": "0000-0001-9804-7103", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e8d0c73cfe04e4c8ac85f6429cbb8cf.json"}}, {"family": "Astier-Pe\u00f1a", "given": "Mar\u00eda Pilar", "initials": "MP", "orcid": "0000-0002-3192-7672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/585b3e1ed7df4d63b0342ab0d96ef9c4.json"}}, {"family": "G\u00f3mez-Bravo", "given": "Raquel", "initials": "R", "orcid": "0000-0002-3786-8626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa876914ef4c487aa47e1b3248deaab5.json"}}, {"family": "Lingner", "given": "Heidrun", "initials": "H", "orcid": "0000-0003-2074-0367", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49f1b26a486540968df9724abbce2d0a.json"}}, {"family": "Clinical investigators\u2020", "given": "", "initials": ""}, {"family": "Clinical investigators:", "given": "", "initials": ""}], "type": "journal article", "published": "2023-03-21", "journal": {"title": "Eur J Gen Pract", "issn": "1751-1402", "pages": "2182879", "issn-l": null}, "abstract": "Most COVID-19 patients were treated in primary health care (PHC) in Europe.\n\nTo demonstrate the scope of PHC workflow during the COVID-19 pandemic emphasising similarities and differences of patient's clinical pathways in Europe.\n\nDescriptive, cross-sectional study with data acquired through a semi-structured questionnaire in PHC in 30 European countries, created ad hoc and agreed upon among all researchers who participated in the study. GPs from each country answered the approved questionnaire. Main variable: PHC COVID-19 acute clinical pathway. All variables were collected from each country as of September 2020.\n\nCOVID-19 clinics in PHC facilities were organised in 8/30. Case detection and testing were performed in PHC in 27/30 countries. RT-PCR and lateral flow tests were performed in PHC in 23/30, free of charge with a medical prescription. Contact tracing was performed mainly by public health authorities. Mandatory isolation ranged from 5 to 14 days. Sick leave certification was given exclusively by GPs in 21/30 countries. Patient hotels or other resources to isolate patients were available in 12/30. Follow-up to monitor the symptoms and/or new complementary tests was made mainly by phone call (27/30). Chest X-ray and phlebotomy were performed in PHC in 18/30 and 23/30 countries, respectively. Oxygen and low-molecular-weight heparin were available in PHC (21/30).\n\nIn Europe PHC participated in many steps to diagnose, treat and monitor COVID-19 patients. Differences among countries might be addressed at European level for the management of future pandemics.", "doi": "10.1080/13814788.2023.2182879", "pmid": "36943232", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-21T16:07:52.599Z", "modified": "2023-04-21T16:07:53.683Z"}, {"entity": "publication", "iuid": "28cf59f0fd4c4db099e848d6975b0b18", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/28cf59f0fd4c4db099e848d6975b0b18.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/28cf59f0fd4c4db099e848d6975b0b18"}}, "title": "Antiepileptogenesis after Stroke - Trials and Tribulations: Methodological Challenges and Recruitment Results of a Phase II Study with Eslicarbazepine Acetate.", "authors": [{"family": "Koepp", "given": "Matthias J", "initials": "MJ", "orcid": "0000-0002-4277-8000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/862bbdee43044d5594cce53574a38387.json"}}, {"family": "Trinka", "given": "Eugen", "initials": "E", "orcid": "0000-0002-5950-2692", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1618693eb8bf416e8891ab2931877a89.json"}}, {"family": "Mah", "given": "Yee-Haur", "initials": "YH"}, {"family": "Bentes", "given": "Carla", "initials": "C", "orcid": "0000-0003-2399-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/152174fbb79b40f0be4db0ba5a05a5b1.json"}}, {"family": "Knake", "given": "Susanne", "initials": "S"}, {"family": "Gigli", "given": "Gian Luigi", "initials": "GL"}, {"family": "Serratosa", "given": "Jos\u00e9 M", "initials": "JM"}, {"family": "Zelano", "given": "Johan", "initials": "J", "orcid": "0000-0001-9445-4545", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1188e644aaa41c4841cf6acbc1ee11a.json"}}, {"family": "Magalh\u00e3es", "given": "Lu\u00eds M", "initials": "LM"}, {"family": "Pereira", "given": "Ana", "initials": "A"}, {"family": "Moreira", "given": "Joana", "initials": "J"}, {"family": "Soares-da-Silva", "given": "Patr\u00edcio", "initials": "P", "orcid": "0000-0002-2446-5078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59911af4073b40809de32fdb7c104739.json"}}], "type": "journal article", "published": "2023-03-21", "journal": {"title": "Epilepsia Open", "issn": "2470-9239", "issn-l": null}, "abstract": "There is currently no evidence to support the use of antiseizure medications to prevent unprovoked seizures following stroke. Experimental animal models suggested a potential antiepileptogenic effect for eslicarbazepine acetate (ESL), and a Phase II, multicentre, randomised, double-blind, placebo-controlled study was designed to test this hypothesis and assess whether ESL treatment for 1 month can prevent unprovoked seizures following stroke. We outline the design and status of this antiepileptogenesis study, and discuss the challenges encountered in its execution to date. Patients at high risk of developing unprovoked seizures after acute intracerebral haemorrhage or acute ischaemic stroke were randomised to receive ESL 800 mg/day or placebo, initiated within 120 hours after primary stroke occurrence. Treatment continued until Day 30, then tapered off. Patients could receive all necessary therapies for stroke treatment according to clinical practice guidelines and standard of care, and are being followed up for 18 months. The primary efficacy endpoint is occurrence of a first unprovoked seizure within 6 months after randomisation ('failure rate'). Secondary efficacy assessments include occurrence of a first unprovoked seizure during 12 months after randomisation and during the entire study; functional outcomes (Barthel Index original 10-item version; National Institutes of Health Stroke Scale); post-stroke depression (Patient Health Questionnaire-9; PHQ-9); and overall survival. Safety assessments include evaluation of treatment-emergent adverse events; laboratory parameters; vital signs; electrocardiogram; suicidal ideation and behaviour (PHQ-9 question 9). The protocol aimed to randomise approximately 200 patients (1:1), recruited from 21 sites in seven European countries and Israel. Despite the challenges encountered, particularly during the COVID-19 pandemic, the study progressed and included a remarkable number of patients, with 129 screened and 125 randomised. Recruitment was stopped after 30 months, the first patient entered in May 2019, and the study is ongoing and following up on patients according to the Clinical Trial Protocol.", "doi": "10.1002/epi4.12735", "pmid": "36944588", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-21T16:07:35.824Z", "modified": "2023-04-21T16:07:36.005Z"}, {"entity": "publication", "iuid": "f99416f34ecf45aa935971c0406d6b38", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f99416f34ecf45aa935971c0406d6b38.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f99416f34ecf45aa935971c0406d6b38"}}, "title": "The burden of disease due to COVID-19 in Sweden 2020-2021: A disability-adjusted life years (DALYs) study.", "authors": [{"family": "Shedrawy", "given": "Jad", "initials": "J", "orcid": "0000-0002-2700-0727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b9672a195ee45fea4ed03b72e371df4.json"}}, {"family": "Ernst", "given": "Patricia", "initials": "P"}, {"family": "L\u00f6nnroth", "given": "Knut", "initials": "K", "orcid": "0000-0001-6944-0256", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a9b9783181c4e63a6edf4985c1b299d.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2023-03-20", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "14034948231160616", "issn-l": "1403-4948"}, "abstract": "The burden of COVID-19 disease can be measured in terms of disability-adjusted life years (DALYs), which is composed of two components: the years of life lost through premature death (YLL) and the number of years lived with disability (YLD), adjusted for level of disability. This study measured DALYs due to COVID-19 in Sweden and compared it to the burden of other diseases.\n\nThe methodology used in the calculation of DALYs was based on the Global Burden of Disease guidelines. The number of patients diagnosed with mild/moderate, severe or critical COVID-19 and/or post-COVID-19 condition between March 2020 and October 2021 was extracted from national registries and used for YLD calculations. In addition, the numbers of death due to COVID-19 in different age groups were used for the YLL calculation.\n\nDuring the study period, 152,877 DALYs were lost to COVID-19 in Sweden, 99.3% of which was attributed to YLL. Loss of DALYs occurred mainly among the elderly, with 66.8% of DALYs attributed to individuals >70 years old. Compared to other diseases, the burden of COVID-19 in 2020 ranked as the eighth leading cause of DALY lost.\n\nSimilar to other countries, the burden of COVID-19 in Sweden was concentrated mainly among the elderly, who contributed most of the DALY lost due to premature mortality. Yet, DALY loss remained lower for COVID-19 than for several other diseases. The contribution of YLD to DALYs lost was minimal. However empirical data on the occurrence and disability of post-COVID-19 condition are scarce, and YLD may therefore be underestimated.", "doi": "10.1177/14034948231160616", "pmid": "36941820", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10033504"}], "notes": [], "created": "2023-04-21T16:08:06.283Z", "modified": "2023-04-21T16:08:06.349Z"}, {"entity": "publication", "iuid": "b69a5c3107a1457baeb8447e677bdd8d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b69a5c3107a1457baeb8447e677bdd8d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b69a5c3107a1457baeb8447e677bdd8d"}}, "title": "Prevalence of depression among students at a Sri Lankan University: A study using the Patient Health Questionnaire-9 (PHQ-9) during the COVID-19 pandemic.", "authors": [{"family": "Wickramasinghe", "given": "Ayanthi", "initials": "A"}, {"family": "Ess\u00e9n", "given": "Birgitta", "initials": "B"}, {"family": "Surenthirakumaran", "given": "Rajendra", "initials": "R"}, {"family": "Axemo", "given": "Pia", "initials": "P"}], "type": "journal article", "published": "2023-03-20", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "23", "issue": "1", "pages": "528", "issn-l": null}, "abstract": "The prevalence of mental health disorders is known to be high among university students globally. Currently there are only a few studies on depression among university students in Sri Lanka. The aim of this study was to screen for the prevalence of Major Depressive Disorder (MDD) and other forms of depression, and to evaluate the factors associated with MDD.\n\nA cross sectional survey using the Patient Health Questionnaire (PHQ-9) was conducted among 637, second-year students from the faculties of Management Studies & Commerce, Science and Medicine at the University of Jaffna, during the Coronavirus (COVID-19) pandemic. Bivariate associations were assessed using chi-squared tests. Logistic regression was used to evaluate factors associated with any type of ragging.\n\nMDD was considered to have been experienced by 31% of the students. From all three faculties, 70% of the students claimed to have experienced some form of depression ranging from mild to severe. The factor associated with MDD was the students' ethnicity.\n\nDue to the high MDD risk among university students, it is imperative to develop psychosocial interventions to ensure early detection of mental health disorders and provide adequate support to safeguard this vulnerable population.", "doi": "10.1186/s12889-023-15427-y", "pmid": "36941588", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10026232"}, {"db": "pii", "key": "10.1186/s12889-023-15427-y"}], "notes": [], "created": "2023-04-21T16:08:15.824Z", "modified": "2023-04-21T16:08:15.837Z"}, {"entity": "publication", "iuid": "0e2e7e401ebe4519acc47ee41c2dbb0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e2e7e401ebe4519acc47ee41c2dbb0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e2e7e401ebe4519acc47ee41c2dbb0e"}}, "title": "Physical and mental health impact of the COVID-19 pandemic at first year in a Spanish adult cohort.", "authors": [{"family": "Castellvi Obiols", "given": "Pere", "initials": "P", "orcid": "0000-0002-3920-8576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5f47e2d780149d2b28dd7079b83858d.json"}}, {"family": "Miranda-Mendizabal", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3649-7509", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f0dbcee3855458bad3a28364ca06660.json"}}, {"family": "Recoder", "given": "Silvia", "initials": "S", "orcid": "0000-0001-9012-0951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2a5bf86399b4f9db4f65ed751dcba55.json"}}, {"family": "Calbo Sebastian", "given": "Ester", "initials": "E", "orcid": "0000-0001-7750-5347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3002f2d890964d378c40eb3ff608e5fc.json"}}, {"family": "Casajuana-Closas", "given": "Marc", "initials": "M", "orcid": "0000-0001-5653-996X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb15f80de6ee4c859881cf3be4302594.json"}}, {"family": "Leiva", "given": "David", "initials": "D", "orcid": "0000-0003-1314-2588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/130239894726413d964750770b59a970.json"}}, {"family": "Manolov", "given": "Rumen", "initials": "R", "orcid": "0000-0002-9387-1926", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2edbbf5db29d412b9d1201a5abbdedd8.json"}}, {"family": "Matilla-Santander", "given": "Nuria", "initials": "N", "orcid": "0000-0002-5249-102X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a546005ec44e4c1c8ba3bed29bffbb5d.json"}}, {"family": "Lloveras-Bernat", "given": "Isaac", "initials": "I"}, {"family": "Forero", "given": "Carlos G", "initials": "CG", "orcid": "0000-0002-5245-0076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4c978c5182343b880503a902be6b36a.json"}}], "type": "journal article", "published": "2023-03-20", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "13", "issue": "1", "pages": "4547", "issn-l": "2045-2322"}, "abstract": "The COVID-19 pandemic and the political and health measures have profoundly affected the health of our populations. However, very few studies have been published assessing its impact using a prospective cohort. The aim of this study is to describe the impact on physical and mental health due to the COVID-19 pandemic in the general population in Spain, and according to COVID-19 clinical status, during the first year of the pandemic. A longitudinal cohort study with two online surveys were performed on a representative sample of the adult Spanish population before (N = 2005, October/November 2019) and during the pandemic (N = 1357, November/December 2020). We assessed disability using the World Health Organisation Disability Assessment Schedule (WHODAS), major depressive episode (MDE) and suicidal thoughts and behaviours (STB), using an adapted version of the Composite International Diagnostic Interview (CIDI 3.0); generalised anxiety disorder (GAD) using the GAD-7 scale; post-traumatic stress disorder (PTSD) symptoms using the PTSD checklist for DSM-5 (PCL-5). For physical health, there was a statistically significant loss of weight (mean/SD) (T0, 73.22/15.56 vs. T1, 71.21/11.94), less use of tobacco (T0, 11.4% vs. T1, 9.0%) and decreased disability (mean/SD) (T0, 21.52/9.22 vs. T1, 19.03/7.32). For mental health, there was a significant increase in MDE (T0, 6.5% vs. T1, 8.8%) and in the prevalence of GAD (T0, 13.7% vs. T1, 17.7%). The prevalence of STB (T0, 15.1% vs. T1, 7.1%) significantly decreased. Individuals who declared they had been diagnosed with COVID-19 (3.6%) showed a worsening in physical health and an increase in mental health problems and PTSD symptoms. Although suicide risk during the first year of the pandemic was significantly less, many suicide risk factors increased: such as the incidence and persistence of MDE and GAD, the presence of PTSD symptoms in those diagnosed with COVID-19, and a worsening in self-assessed health status. We expect an increase in STB in the population in the long-term. Future research should gather information about the long-term impact of the pandemic.", "doi": "10.1038/s41598-023-28336-2", "pmid": "36941282", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10026238"}, {"db": "pii", "key": "10.1038/s41598-023-28336-2"}], "notes": [], "created": "2023-04-21T16:08:29.984Z", "modified": "2023-04-21T16:08:30.303Z"}, {"entity": "publication", "iuid": "06be7b4ac8c447758d200492540d935c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/06be7b4ac8c447758d200492540d935c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/06be7b4ac8c447758d200492540d935c"}}, "title": "Coping with COVID-19 Pandemic and Sustained Health Behavior: A Cross-Sectional Study in Bangladesh.", "authors": [{"family": "Sizear", "given": "Monaemul Islam", "initials": "MI"}, {"family": "Macassa", "given": "Gloria", "initials": "G", "orcid": "0000-0003-4415-7942", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90dedd73015141c287bc67122ace3764.json"}}, {"family": "Chowdhury", "given": "Mohammad Rocky Khan", "initials": "MRK"}, {"family": "Rashid", "given": "Mamunur", "initials": "M", "orcid": "0000-0001-7558-4168", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f94086e479574c90a4bd63fac5ce70ad.json"}}], "type": "journal article", "published": "2023-03-20", "journal": {"title": "Epidemiologia (Basel)", "issn": "2673-3986", "volume": "4", "issue": "1", "pages": "85-93", "issn-l": null}, "abstract": "During the COVID-19 pandemic, people's health behavioral changes have been transposed into a new dimension. Coping with the COVID-19 pandemic may have an impact on sustained health behavior (SHB). Therefore, this study aimed to explore the validity and reliability of the COVID-19 Coping Scale among working-age individuals and to assess whether coping with COVID-19-related stress could influence SHB in this population. A cross-sectional study was conducted based on the population of the city of Dhaka in Bangladesh. A total of 263 working-age individuals (19-65 years) participated in the study. The present study results confirmed the COVID-19 Coping Scale was a valid and reliable instrument for this population. Moreover, the present finding indicated decreased odds of SHB for individuals who rated lower scores on coping with COVID-19 compared to individuals who rated higher scores; the result remained significant after controlling for gender and education (OR 0.68, 95% CI: 0.54-0.87). The present study suggests two important findings: (i) the instrument used in this study was valid and reliable in this population, and (ii) coping with COVID-19-related stress may be an important aspect of practicing SHB. Policymakers may use the highlighted findings to facilitate sustainable health behavior for long-term health benefits and to tackle future pandemics like COVID-19 or in a similar context.", "doi": "10.3390/epidemiologia4010009", "pmid": "36975617", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10048345"}, {"db": "pii", "key": "epidemiologia4010009"}], "notes": [], "created": "2023-04-21T15:59:19.227Z", "modified": "2023-04-21T15:59:19.323Z"}, {"entity": "publication", "iuid": "ece960f599fd4e9a893444d788d8dbdc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ece960f599fd4e9a893444d788d8dbdc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ece960f599fd4e9a893444d788d8dbdc"}}, "title": "Computerization of the Work of General Practitioners: Mixed Methods Survey of Final-Year Medical Students in Ireland.", "authors": [{"family": "Blease", "given": "Charlotte", "initials": "C", "orcid": "0000-0003-3657-2476", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af05b93e66b34265808f33799070ef16.json"}}, {"family": "Kharko", "given": "Anna", "initials": "A", "orcid": "0000-0003-0908-6173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a367f676bc334b7fbdcae307d5e292a2.json"}}, {"family": "Bernstein", "given": "Michael", "initials": "M", "orcid": "0000-0001-7221-0697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe1a4546ab09474c97096de65036f69a.json"}}, {"family": "Bradley", "given": "Colin", "initials": "C", "orcid": "0000-0002-3595-9567", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61ed23f766504570b950289fc569f806.json"}}, {"family": "Houston", "given": "Muiris", "initials": "M", "orcid": "0000-0003-4124-8523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce99d9a5ea2c474bb6185c69ff21ffdc.json"}}, {"family": "Walsh", "given": "Ian", "initials": "I", "orcid": "0000-0002-3750-2499", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c81f5124483a41b5b4b87fb60875bba6.json"}}, {"family": "D Mandl", "given": "Kenneth", "initials": "K", "orcid": "0000-0002-9781-0477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4fb859839a7d46eb963d58e8fa0cab58.json"}}], "type": "journal article", "published": "2023-03-20", "journal": {"title": "JMIR Med Educ", "issn": "2369-3762", "volume": "9", "pages": "e42639", "issn-l": null}, "abstract": "The potential for digital health technologies, including machine learning (ML)-enabled tools, to disrupt the medical profession is the subject of ongoing debate within biomedical informatics.\n\nWe aimed to describe the opinions of final-year medical students in Ireland regarding the potential of future technology to replace or work alongside general practitioners (GPs) in performing key tasks.\n\nBetween March 2019 and April 2020, using a convenience sample, we conducted a mixed methods paper-based survey of final-year medical students. The survey was administered at 4 out of 7 medical schools in Ireland across each of the 4 provinces in the country. Quantitative data were analyzed using descriptive statistics and nonparametric tests. We used thematic content analysis to investigate free-text responses.\n\nIn total, 43.1% (252/585) of the final-year students at 3 medical schools responded, and data collection at 1 medical school was terminated due to disruptions associated with the COVID-19 pandemic. With regard to forecasting the potential impact of artificial intelligence (AI)/ML on primary care 25 years from now, around half (127/246, 51.6%) of all surveyed students believed the work of GPs will change minimally or not at all. Notably, students who did not intend to enter primary care predicted that AI/ML will have a great impact on the work of GPs.\n\nWe caution that without a firm curricular foundation on advances in AI/ML, students may rely on extreme perspectives involving self-preserving optimism biases that demote the impact of advances in technology on primary care on the one hand and technohype on the other. Ultimately, these biases may lead to negative consequences in health care. Improvements in medical education could help prepare tomorrow's doctors to optimize and lead the ethical and evidence-based implementation of AI/ML-enabled tools in medicine for enhancing the care of tomorrow's patients.", "doi": "10.2196/42639", "pmid": "36939809", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "v9i1e42639"}], "notes": [], "created": "2023-04-21T16:09:17.739Z", "modified": "2023-04-21T16:09:17.978Z"}, {"entity": "publication", "iuid": "c36f8f54506f4c818e2bf18f5a4a6a80", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c36f8f54506f4c818e2bf18f5a4a6a80.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c36f8f54506f4c818e2bf18f5a4a6a80"}}, "title": "Vulval Aphthous Ulcers in Adolescents Following COVID-19 Vaccination - Analysis of an international case series.", "authors": [{"family": "Rudolph", "given": "Annette", "initials": "A"}, {"family": "Savage", "given": "Dr Ruth", "initials": "DR"}], "type": "journal article", "published": "2023-03-17", "journal": {"title": "J Pediatr Adolesc Gynecol", "issn": "1873-4332", "issn-l": null}, "abstract": "To review and characterise reports of vulval aphthous ulcers (VAU) following COVID-19 vaccination in VigiBase, the World Health Organization global database of reported potential side effects of medicinal products, to demonstrate the importance and power of case reports for rare suspected adverse reactions and to investigate whether they suggest a potential for COVID-19 vaccination to be a trigger.\n\nCases reporting the Medical Dictionary for Regulatory Activities' (MedDRA) Preferred Term (PT) \"Vulvovaginal ulceration\" and related PTs in adolescent patients aged 12 to 17 years in association with any COVID-19 vaccine were extracted from VigiBase. The cases were clinically reviewed, and causality was assessed by applying the Bradford Hill criteria to the obtained case series.\n\nAs of June 30th, 2022, there were 444 reports for the selected MedDRA PTs following COVID-19 vaccination in VigiBase. Ninety-four de-duplicated reports concerned adolescent female patients. Thirty-seven cases were clinically consistent with the diagnosis of VAU. Upon causality assessment, the analysed case series fulfilled six of the nine Austen Bradford Hill criteria supporting a potential causal relationship.\n\nVAU can be perceived as a traumatic experience, especially in adolescent patients. There is, furthermore, a risk that the ulcers will be misdiagnosed resulting in avoidable investigation and treatment burdens for patients. We communicate our findings to support the small number of published case reports and raise awareness of VAU occurring in a temporal association with COVID-19 vaccination. Furthermore, our analysis supports observations about the value of case reports for the recognition and assessment of rare adverse events.", "doi": "10.1016/j.jpag.2023.03.006", "pmid": "36934803", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10020135"}, {"db": "pii", "key": "S1083-3188(23)00311-X"}], "notes": [], "created": "2023-04-21T16:11:18.536Z", "modified": "2023-04-21T16:11:18.564Z"}, {"entity": "publication", "iuid": "1a0d84990b34405eabcad32112e03176", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1a0d84990b34405eabcad32112e03176.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1a0d84990b34405eabcad32112e03176"}}, "title": "Severe COVID-19 during pregnancy in Sweden, Norway, and Denmark.", "authors": [{"family": "\u00d6rtqvist", "given": "Anne K", "initials": "AK", "orcid": "0000-0001-9019-9233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7bfdbeb2a2d848ec928a6c7f7d112465.json"}}, {"family": "Magnus", "given": "Maria C", "initials": "MC", "orcid": "0000-0002-0568-3774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3530918cfd534021a45a80628c89c580.json"}}, {"family": "Aabakke", "given": "Anna J M", "initials": "AJM", "orcid": "0000-0003-4754-506X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c142bd2b1fc84a7e864d2af58096bcaf.json"}}, {"family": "Urhoj", "given": "Stine Kjaer", "initials": "SK", "orcid": "0000-0002-2069-9723", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b924cc03db2b4fffbb075e2d7e3579ac.json"}}, {"family": "Vinkel Hansen", "given": "Anne", "initials": "A", "orcid": "0000-0003-4523-3521", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7045d9cc7a814e718d962615eebe0a1a.json"}}, {"family": "Nybo Andersen", "given": "Anne-Marie", "initials": "AM"}, {"family": "Krebs", "given": "Lone", "initials": "L", "orcid": "0000-0001-5433-4776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1efab04a970448494fc2e06bfa3a55c.json"}}, {"family": "Pettersson", "given": "Karin", "initials": "K"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE", "orcid": "0000-0002-2199-5225", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eaa51eb1c42a4b12b21b248e363fbf04.json"}}, {"family": "Stephansson", "given": "Olof", "initials": "O", "orcid": "0000-0003-1528-4563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39af50356a574c80ba6bd2227ecb5cf5.json"}}], "type": "journal article", "published": "2023-03-17", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "issn-l": "0001-6349"}, "abstract": "Pregnancy is a risk factor for severe coronavirus disease 2019 (COVID-19) and adverse pregnancy outcomes. We aimed to explore maternal characteristics, pregnancy outcomes, vaccination status, and virus variants among pregnant women admitted to intensive care units (ICU) with severe COVID-19.\n\nWe identified pregnant women admitted to ICU in Sweden (n = 96), Norway (n = 31), and Denmark (n = 16) because of severe COVID-19, from national registers and clinical databases between March 2020 and February 2022 (Denmark), August 2022 (Sweden), or December 2022 (Norway). Their background characteristics, pregnancy outcome, and vaccination status were compared with all birthing women and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test-positive pregnant women during the same time period. We calculated the number admitted to ICU per 10 000 birthing and per 1000 SARS-CoV-2 test-positive women during the Index, Alpha, Delta, and Omicron periods.\n\nWomen admitted to ICU had a higher mean body mass index, were more often of non-Scandinavian origin, had on average lower education and income levels, had a higher proportion of chronic and pregnancy-related conditions, delivered preterm, had neonates with low Apgar scores, and had more infants admitted to neonatal care, compared with all birthing and test-positive pregnant women. Of those admitted to ICU, only 7% had been vaccinated before admission. Overall, the highest proportion of women admitted to ICU per birthing was during the Delta period (4.1 per 10 000 birthing women). In Norway, the highest proportion admitted to ICU per test-positive pregnant women was during the Delta period (17.8 per 1000 test-positive), whereas the highest proportion of admitted per test-positive in Sweden and Denmark was seen during the Index period (15.4 and 8.9 per 1000 test-positive, respectively).\n\nAdmission to ICU because of COVID-19 in pregnancy was a rare event in the Scandinavian countries, but women who were unvaccinated, of non-Scandinavian origin, and with lower socio-economic status were at higher risk of admission to ICU. In addition, women admitted to ICU for COVID-19 had higher risk of adverse pregnancy outcomes.", "doi": "10.1111/aogs.14552", "pmid": "36928990", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-21T16:12:18.383Z", "modified": "2023-04-21T16:12:18.648Z"}, {"entity": "publication", "iuid": "86b59b89448646ff8a5c908dc1d5c06d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86b59b89448646ff8a5c908dc1d5c06d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86b59b89448646ff8a5c908dc1d5c06d"}}, "title": "Correction: Study protocol for a randomized controlled trial evaluating the effectiveness of an internet-based self-help intervention to cope with psychological distress due to COVID-19 in the Italian general population: the RinasciMENTE project.", "authors": [{"family": "Bertuzzi", "given": "Vanessa", "initials": "V", "orcid": "0000-0002-8541-5357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7abc069e75034b0e96265c7d48fb95a2.json"}}, {"family": "Semonella", "given": "Michelle", "initials": "M"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Manzoni", "given": "Gian Mauro", "initials": "GM"}, {"family": "Castelnuovo", "given": "Gianluca", "initials": "G"}, {"family": "Molinari", "given": "Enrico", "initials": "E"}, {"family": "Pietrabissa", "given": "Giada", "initials": "G"}], "type": "published erratum", "published": "2023-03-17", "journal": {"title": "Trials", "issn": "1745-6215", "volume": "24", "issue": "1", "pages": "201", "issn-l": null}, "abstract": null, "doi": "10.1186/s13063-023-07217-z", "pmid": "36932452", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10022985"}, {"db": "pii", "key": "10.1186/s13063-023-07217-z"}], "notes": [], "created": "2023-04-21T16:12:08.811Z", "modified": "2023-04-21T16:12:08.820Z"}, {"entity": "publication", "iuid": "c2ec02b31430403383952bf3cb8e1445", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2ec02b31430403383952bf3cb8e1445.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2ec02b31430403383952bf3cb8e1445"}}, "title": "Life Satisfaction among Self-Employed People in Different Welfare Regimes during the COVID-19 Pandemic: Significance of Household Finances and Concerns about Work.", "authors": [{"family": "Nordenmark", "given": "Mikael", "initials": "M"}, {"family": "Landstad", "given": "Bodil J", "initials": "BJ", "orcid": "0000-0001-6558-3129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bdb9f75451d4f2b8c87a8f8a837a09d.json"}}, {"family": "Tjulin", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Vinberg", "given": "Stig", "initials": "S", "orcid": "0000-0002-5935-5688", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c63c4ca58d242d18741dba0b0af5afb.json"}}], "type": "journal article", "published": "2023-03-15", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "20", "issue": "6", "issn-l": null}, "abstract": "Most studies have shown that self-employed people have higher levels of life satisfaction than employed people due to high levels of job satisfaction, work flexibility, and job control. However, during the COVID-19 pandemic, many self-employed people experienced economic strain and worried about the situation of their employees and survival of the company. The aim of this study was to examine the level of life satisfaction among self-employed people during the COVID-19 pandemic in different welfare regimes. Analyses were mainly based on Eurofound's \"Living, Working and COVID-19\" online survey. Fieldwork took place between April and June 2020 in 27 EU countries. The results showed that there was a significantly lower level of life satisfaction among self-employed people than employed people during the pandemic. This was in contrast to analyses from approximately one year before the pandemic, which showed that life satisfaction was higher among self-employed people. The main reasons for this lower level of life satisfaction among the self-employed during the pandemic were worse household financial situation and more worries about their job. Analyses of life satisfaction among the self-employed in different welfare regimes indicated that self-employed people in the Nordic welfare state regime largely kept their relatively high level of life satisfaction during the pandemic, but this was not the case for self-employed people in other welfare regimes.", "doi": "10.3390/ijerph20065141", "pmid": "36982050", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10049569"}, {"db": "pii", "key": "ijerph20065141"}], "notes": [], "created": "2023-04-21T15:57:00.390Z", "modified": "2023-04-21T15:57:50.063Z"}, {"entity": "publication", "iuid": "2b48e1851208422999e1cae7b9e92800", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b48e1851208422999e1cae7b9e92800.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b48e1851208422999e1cae7b9e92800"}}, "title": "COVID-19 and income inequality: evidence from monthly population registers.", "authors": [{"family": "Angelov", "given": "Nikolay", "initials": "N"}, {"family": "Waldenstr\u00f6m", "given": "Daniel", "initials": "D", "orcid": "0000-0002-0940-2466", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1941a15d28f44dc8f42615088795534.json"}}], "type": "journal article", "published": "2023-03-15", "journal": {"title": "J Econ Inequal", "issn": "1569-1721", "issn-l": null, "volume": null, "issue": null, "pages": "1-29"}, "abstract": "We measure the distributional impact of the COVID-19 pandemic using newly released population register data in Sweden. Monthly earnings inequality increased during the pandemic, and the key driver is income losses among low-paid individuals while middle- and high-income earners were almost unaffected. In terms of employment, as measured by having positive monthly earnings, the pandemic had a larger negative impact on private-sector workers and on women. In terms of earnings conditional on being employed, the effect was still more negative for women, but less negative for private-sector workers compared to publicly employed. Using data on individual take-up of government COVID-19 support, we show that policy significantly dampened the inequality increase, but did not fully offset it. Annual total market income inequality, which also includes capital income and taxable transfers, shows similar patterns of increasing inequality during the pandemic.\r\n\r\nThe online version contains supplementary material available at 10.1007/s10888-022-09560-8.", "doi": "10.1007/s10888-022-09560-8", "pmid": "37360569", "labels": {"Category: Public Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10015130"}, {"db": "pii", "key": "9560"}], "notes": [], "created": "2023-10-04T09:31:51.035Z", "modified": "2023-10-04T10:56:21.962Z"}, {"entity": "publication", "iuid": "87617a1379e04fb7aa3b32595d1bc9d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87617a1379e04fb7aa3b32595d1bc9d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87617a1379e04fb7aa3b32595d1bc9d9"}}, "title": "Recruitment of Adolescent Young Carers to a Psychosocial Support Intervention Study in Six European Countries: Lessons Learned from the ME-WE Project.", "authors": [{"family": "Barbabella", "given": "Francesco", "initials": "F"}, {"family": "Magnusson", "given": "Lennart", "initials": "L"}, {"family": "Boccaletti", "given": "Licia", "initials": "L"}, {"family": "Casu", "given": "Giulia", "initials": "G", "orcid": "0000-0001-5441-3044", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7cd6e9e8122e40fb8aa1fd15dff39c9f.json"}}, {"family": "Hlebec", "given": "Valentina", "initials": "V"}, {"family": "Bolko", "given": "Irena", "initials": "I"}, {"family": "Lewis", "given": "Feylyn", "initials": "F", "orcid": "0000-0003-2306-8182", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35b1b33cf19e44a895362c21b4184b08.json"}}, {"family": "Hoefman", "given": "Renske", "initials": "R", "orcid": "0000-0003-4533-2562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/979bca9baba2402e8c03397c113d9bd2.json"}}, {"family": "Brolin", "given": "Rosita", "initials": "R"}, {"family": "Santini", "given": "Sara", "initials": "S", "orcid": "0000-0003-4705-4631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0b2248297e14350917aa7ec610d87f4.json"}}, {"family": "Socci", "given": "Marco", "initials": "M", "orcid": "0000-0001-9093-2167", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff1725877f3344b9bfa11c4fafa40e9d.json"}}, {"family": "D'Amen", "given": "Barbara", "initials": "B", "orcid": "0000-0002-8986-5216", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ccb20d6201a47d887799947d62154b3.json"}}, {"family": "de Jong", "given": "Yvonne", "initials": "Y"}, {"family": "Bouwman", "given": "Tamara", "initials": "T"}, {"family": "de Jong", "given": "Nynke", "initials": "N"}, {"family": "Leu", "given": "Agnes", "initials": "A", "orcid": "0000-0002-5451-837X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e084dede367e4310bdfd006ad84499eb.json"}}, {"family": "Phelps", "given": "Daniel", "initials": "D"}, {"family": "Guggiari", "given": "Elena", "initials": "E", "orcid": "0000-0002-8656-9825", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc16e1d387114fc482d40dd5be7e89d9.json"}}, {"family": "Wirth", "given": "Alexandra", "initials": "A"}, {"family": "Morgan", "given": "Vicky", "initials": "V"}, {"family": "Becker", "given": "Saul", "initials": "S"}, {"family": "Hanson", "given": "Elizabeth", "initials": "E", "orcid": "0000-0001-7609-4822", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1652497e6384360bc8c55d2670be4a9.json"}}], "type": "randomized controlled trial", "published": "2023-03-14", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "20", "issue": "6", "issn-l": null}, "abstract": "Young carers provide a substantial amount of care to family members and support to friends, yet their situation has not been actively addressed in research and policy in many European countries or indeed globally. Awareness of their situation by professionals and among children and young carers themselves remains low overall. Thus, young carers remain a largely hidden group within society. This study reports and analyses the recruitment process in a multi-centre intervention study offering psychosocial support to adolescent young carers (AYCs) aged 15-17 years. A cluster-randomised controlled trial was designed, with recruitment taking place in Italy, the Netherlands, Slovenia, Sweden, Switzerland and the United Kingdom exploiting various channels, including partnerships with schools, health and social services and carers organisations. In total, 478 AYCs were recruited and, after screening failures, withdrawals and initial dropouts, 217 were enrolled and started the intervention. Challenges encountered in reaching, recruiting and retaining AYCs included low levels of awareness among AYCs, a low willingness to participate in study activities, uncertainty about the prevalence of AYCs, a limited school capacity to support the recruitment; COVID-19 spreading in 2020-2021 and related restrictions. Based on this experience, recommendations are put forward for how to better engage AYCs in research.", "doi": "10.3390/ijerph20065074", "pmid": "36981983", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10049644"}, {"db": "pii", "key": "ijerph20065074"}], "notes": [], "created": "2023-04-21T15:58:06.553Z", "modified": "2023-04-21T15:58:06.801Z"}, {"entity": "publication", "iuid": "39efdd3d431f44b8bea54043da5f5f6d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/39efdd3d431f44b8bea54043da5f5f6d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/39efdd3d431f44b8bea54043da5f5f6d"}}, "title": "The COVID-19 endemic in Vietnam: Contextual considerations and implications.", "authors": [{"family": "Doan", "given": "Linh Phuong", "initials": "LP"}, {"family": "Le Vu", "given": "Minh Ngoc", "initials": "MN"}, {"family": "Vu", "given": "Giang Thu", "initials": "GT"}, {"family": "Le", "given": "Huong Thi", "initials": "HT"}, {"family": "Nguyen", "given": "Long Hoang", "initials": "LH"}, {"family": "Latkin", "given": "Carl A", "initials": "CA"}, {"family": "Ho", "given": "Roger C M", "initials": "RCM"}], "type": "journal article", "published": "2023-03-13", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "11", "pages": "997635", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2023.997635", "pmid": "36992873", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10040746"}], "notes": [], "created": "2023-04-21T15:55:27.197Z", "modified": "2023-04-21T15:55:27.201Z"}, {"entity": "publication", "iuid": "10e18b6f1cc6468784325fed2801dbcf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/10e18b6f1cc6468784325fed2801dbcf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/10e18b6f1cc6468784325fed2801dbcf"}}, "title": "NK cells in COVID-19 - from disease to vaccination.", "authors": [{"family": "Hammer", "given": "Quirin", "initials": "Q"}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Bister", "given": "Jonna", "initials": "J"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4691d38f3268433696d7c65ea235a12b.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}], "type": "journal article", "published": "2023-03-11", "journal": {"title": "J Leukoc Biol", "issn": "1938-3673", "issn-l": null}, "abstract": "Natural killer (NK) cells participate in the host innate immune response to viral infection. Conversely, NK cell dysfunction and hyperactivation can contribute to tissue damage and immunopathology. Here, we review recent studies with respect to NK cell activity during infection with human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Discussed are initial reports of patients hospitalized with coronavirus disease 2019 (COVID-19), which revealed prompt NK cell activation during the acute disease state. Another hallmark of COVID-19, early on observed, was a decrease in numbers of NK cells in the circulation. Data from patients with acute SARS-CoV-2 infection as well as from in vitro models demonstrated strong anti-SARS-CoV-2 activity by NK cells, likely through direct cytotoxicity as well as indirectly by secreting cytokines. Additionally, we describe the molecular mechanisms underlying NK cell recognition of SARS-CoV-2 infected cells, which involve triggering of multiple activating receptors including NKG2D as well as loss-of-inhibition through NKG2A. Discussed is also the ability of NK cells to respond to SARS-CoV-2 infection via antibody dependent cellular cytotoxicity. With the respect to NK cells in the pathogenesis of COVID-19, we review studies demonstrating how hyperactivation and misdirected NK cell responses could contribute to disease course. Finally, while knowledge is still rather limited, we discuss current insights suggesting a contribution of an early NK cell activation-response in the generation of immunity against SARS-CoV-2 following vaccination an anti-SARS-CoV-2 mRNA vaccines.", "doi": "10.1093/jleuko/qiad031", "pmid": "36976012", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7076154"}], "notes": [], "created": "2023-04-21T15:59:08.245Z", "modified": "2023-04-21T15:59:08.257Z"}, {"entity": "publication", "iuid": "01c42b267cba4509987e4de5e9f89818", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01c42b267cba4509987e4de5e9f89818.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01c42b267cba4509987e4de5e9f89818"}}, "title": "COVID-19 and unfavorable changes in mental health unrelated to changes in physical activity, sedentary time, and health behaviors among Swedish adolescents: A longitudinal study.", "authors": [{"family": "Nyberg", "given": "Gisela", "initials": "G"}, {"family": "Helgad\u00f3ttir", "given": "Bj\u00f6rg", "initials": "B"}, {"family": "Kjellenberg", "given": "Karin", "initials": "K"}, {"family": "Ekblom", "given": "\u00d6rjan", "initials": "\u00d6"}], "type": "journal article", "published": "2023-03-10", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "11", "pages": "1115789", "issn-l": "2296-2565"}, "abstract": "The COVID-19 pandemic has had major impact on the daily lives of adolescents. This study examined whether mental health outcomes had changed over the pandemic, and if such changes were related to changes in physical activity (PA), sedentary time, sleep, screen time, and participation in organized sports.\n\nIn this longitudinal study, data were collected in autumn 2019 with follow-up measurements in spring 2021. In total, 558 schools were invited and 34 schools around Stockholm with a variation in socioeconomic background were included. Physical activity and sedentary time were measured for seven consecutive days by accelerometry (Actigraph). Anxiety, health-related quality of life (HRQoL), psychosomatic health, stress, sleep duration, screen time, and organized sports participation were self-reported in questionnaires. Linear models were applied to estimate associations between changes in mental health outcomes and exposures.\n\nFrom the baseline sample of 1,139 participants, 585 (55% girls), mean (SD) age 14.9 (0.3) years, participated in the follow-up. Between 2019 and 2021, there was a decrease in HRQoL [mean difference -1.7 (-2.3, -1.2), p < 0.001], increase in psychosomatic health problems [mean difference 1.8 (1.3, 2.3), p < 0.001], and an increase in the number of participants with high stress [from 94 (28%) to 139 (42%), p < 0.001]. Weekly light PA and sleep duration decreased and weekly sedentary time and screen time increased unrelated to changes in mental health outcomes. An increase in sleep duration during weekdays was significantly related to both a decrease in anxiety (B = -0.71, CI: -1.36, -0.06) and an increase in HRQoL (B = 1.00, CI: 0.51, 1.49).\n\nDuring the COVID-19 pandemic, mental health appears to have been impaired in Swedish adolescents, but unrelated to changes in PA, sedentary time, screen time, or participation in organized sports. However, increased sleep duration on weekdays was related to less anxiety and better HRQoL. The results may help policy makers and other stakeholders comprehend the differential effects of the COVID-19 pandemic on mental health outcomes and help guiding the planning of policy actions.\n\nISRCTN15689873.", "doi": "10.3389/fpubh.2023.1115789", "pmid": "36969680", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10036362"}, {"db": "ISRCTN", "key": "ISRCTN15689873"}], "notes": [], "created": "2023-04-21T16:02:18.488Z", "modified": "2023-04-21T16:02:18.493Z"}, {"entity": "publication", "iuid": "fd9ca1a78b3a4cc8aefa609060b3984a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fd9ca1a78b3a4cc8aefa609060b3984a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fd9ca1a78b3a4cc8aefa609060b3984a"}}, "title": "Living through a Global Pandemic: A Cross-Sectional Study on the Psychological Resilience of the University Population in Iran.", "authors": [{"family": "Ahmadi", "given": "Fereshteh", "initials": "F", "orcid": "0000-0002-8823-6434", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f4f676633f24637b135c494dcb33cc9.json"}}, {"family": "Cetrez", "given": "\u00d6nver Andreas", "initials": "\u00d6A", "orcid": "0000-0001-6274-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3070dcb6e8234c9b973573f7172e7821.json"}}, {"family": "Zandi", "given": "Saeid", "initials": "S", "orcid": "0000-0003-1272-7170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a941295613dc468e8282c9f8f157a4b6.json"}}], "type": "journal article", "published": "2023-03-09", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "20", "issue": "6", "issn-l": null}, "abstract": "This study aimed to describe and understand the individual and social dimensions of resiliency among Iranian academics as professionals during the early wave of the ongoing pandemic. Furthermore, we aimed to emphasize the cultural context in our analysis.\n\nA cross-sectional survey design was adopted. We used convenient sampling, administered through an online survey, among academics at Iranian universities (n = 196, 75% women). We employed the CD-RISC 2 instrument, items on life meaning, and a modified version of Pargament's RCOPE instrument (Meaning, Control, Comfort/Spirituality, Intimacy/Spirituality, and Life Transformation).\n\nThe results revealed a strong level of resilience among men (M = 5.78) and women (M = 5.52). Self-rated health was rated as excellent, very good, or good among a majority (92%) of the participants, more so among men. Family was one of the factors that most strongly gave life meaning, followed by friends, work/school, and religion/spirituality. There was a strong correlation between self-rated health and life as part of a greater whole, being alone, and listening to the sounds of the surrounding nature.\n\nBoth personal and social levels of resilience and meaning-making are seen in the results, with an ability to balance between obstacles and resources. Cultural practices are interdependent, which also include the individual and social dimensions of resiliency and meaning-making.", "doi": "10.3390/ijerph20064844", "pmid": "36981752", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10049328"}, {"db": "pii", "key": "ijerph20064844"}], "notes": [], "created": "2023-04-21T15:58:20.899Z", "modified": "2023-04-21T15:58:20.975Z"}, {"entity": "publication", "iuid": "634c2fd0451c41c980c396b1199b3036", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/634c2fd0451c41c980c396b1199b3036.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/634c2fd0451c41c980c396b1199b3036"}}, "title": "Editorial: Medication safety in COVID-19 management, Volume II.", "authors": [{"family": "Das", "given": "Saibal", "initials": "S"}], "type": "editorial", "published": "2023-03-09", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "14", "pages": "1175152", "issn-l": "1663-9812"}, "abstract": null, "doi": "10.3389/fphar.2023.1175152", "pmid": "36969864", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10034399"}, {"db": "pii", "key": "1175152"}], "notes": [], "created": "2023-04-21T16:01:34.408Z", "modified": "2023-04-21T16:01:42.674Z"}, {"entity": "publication", "iuid": "8a242d597bec44148573ceb5c9f65abf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a242d597bec44148573ceb5c9f65abf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a242d597bec44148573ceb5c9f65abf"}}, "title": "\"Having vaccines is good but not enough\": Requirements for optimal COVID-19 immunization program in Vietnam.", "authors": [{"family": "Doan", "given": "Linh Phuong", "initials": "LP"}, {"family": "Dao", "given": "Nam Gia", "initials": "NG"}, {"family": "Nguyen", "given": "Duy Cao", "initials": "DC"}, {"family": "Dang", "given": "Trang Huyen Thi", "initials": "THT"}, {"family": "Vu", "given": "Giang Thu", "initials": "GT"}, {"family": "Nguyen", "given": "Long Hoang", "initials": "LH"}, {"family": "Vu", "given": "Linh Gia", "initials": "LG"}, {"family": "Le", "given": "Huong Thi", "initials": "HT"}, {"family": "Latkin", "given": "Carl A", "initials": "CA"}, {"family": "Ho", "given": "Cyrus S H", "initials": "CSH"}, {"family": "Ho", "given": "Roger C M", "initials": "RCM"}], "type": "journal article", "published": "2023-03-09", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "11", "pages": "1137401", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2023.1137401", "pmid": "36969663", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10033707"}], "notes": [], "created": "2023-04-21T16:02:31.008Z", "modified": "2023-04-21T16:02:31.022Z"}, {"entity": "publication", "iuid": "5abea92c910c4db68a4228c66e465a01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5abea92c910c4db68a4228c66e465a01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5abea92c910c4db68a4228c66e465a01"}}, "title": "Understanding the impact of the COVID\u201119 pandemic on healthcare services for adults during three waves of COVID\u201119 infections: A South African private sector experience.", "authors": [{"family": "Nematswerani", "given": "N", "initials": "N"}, {"family": "Steenkamp", "given": "L", "initials": "L"}, {"family": "Haneef", "given": "S", "initials": "S"}, {"family": "Naidoo", "given": "R M", "initials": "RM"}, {"family": "Fonn", "given": "S", "initials": "S"}], "type": "journal article", "published": "2023-03-08", "journal": {"title": "S Afr Med J", "issn": "2078-5135", "issn-l": null, "volume": "113", "issue": "4", "pages": "e16505"}, "abstract": "Since the onset of the COVID\u201119 pandemic, healthcare resources have been repurposed to focus on COVID\u201119. Resource reallocation and restrictions to movement that affected general access to care may have inadvertently resulted in undue disruptions in the continuum of care for patients requiring non-COVID\u201119 healthcare services.\r\n\r\nTo describe the change in pattern of health service use in the South African (SA) private sector.\r\n\r\nWe conducted a retrospective study of a nationwide cohort of privately insured individuals. An analysis of claims data was performed for non-COVID\u201119 related healthcare services provided from April 2020 to December 2020 (year 1 of COVID\u201119) and April 2021 to December 2021 (year 2 of COVID\u201119) relative to the same period in 2019 prior to the COVID\u201119 pandemic in SA. Over and above plotting the monthly trends, we tested for statistical significance of the changes using a Wilcoxon test given the non-normality of all the outcomes.\r\n\r\nBetween April and December 2020, relative to the same period in 2021, and also relative to the same period in 2019, we found a 31.9% (p<0.01) and a 16.6% (p<0.01) reduction in emergency room visits, respectively; a 35.9% (p<0.01) and 20.5% (p<0.01) reduction in medical hospital admissions; a 27.4% (p=0.01) and 13.0% (p=0.03) reduction in surgical hospital admissions; a 14.5% (p<0.01) and 4.1% (p=0.16) reduction in face-to-face general practitioner consultations for chronic members; a 24.9% (p=0.06) and 5.2% (p=0.54) reduction in mammography for female members; a 23.4% (p=0.03) and 10.8% (p=0.09) reduction in Pap smear screenings for female members; a 16.5% (p=0.08) and 12.1% (p=0.27) reduction in colorectal cancer registrations and an 18.2% (p=0.08) and 8.9% (p=0.07) decrease in all oncology diagnoses. Uptake of telehealth services throughout the healthcare delivery system increased by 5 708% in 2020 compared with 2019, and 36.1% for 2021 compared with 2020.\r\n\r\nA significant reduction in emergency room visits, hospital admissions and utilisation of primary care services was observed since the start of the pandemic. Further research is required to understand if there are long-term consequences of delayed care. An increase in the use of digital consultations was observed. Research on their acceptability and effectiveness may open new modalities of care, which may have cost- and time-saving benefits.", "doi": "10.7196/SAMJ.2023.v113i4.16505", "pmid": "37283155", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:31:48.559Z", "modified": "2023-10-04T10:55:10.601Z"}, {"entity": "publication", "iuid": "b181239c838c4757a71db6e6435ea230", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b181239c838c4757a71db6e6435ea230.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b181239c838c4757a71db6e6435ea230"}}, "title": "Improved outcomes over time and higher mortality in CMV seropositive allogeneic stem cell transplantation patients with COVID-19; An infectious disease working party study from the European Society for Blood and Marrow Transplantation registry.", "authors": [{"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Tridello", "given": "Gloria", "initials": "G"}, {"family": "Pi\u00f1ana", "given": "Jose Luis", "initials": "JL"}, {"family": "Ciceri", "given": "Fabio", "initials": "F"}, {"family": "Sengeloev", "given": "Henrik", "initials": "H"}, {"family": "Kulagin", "given": "Alexander", "initials": "A"}, {"family": "Mielke", "given": "Stephan", "initials": "S"}, {"family": "Yegin", "given": "Zeynep Arzu", "initials": "ZA"}, {"family": "Collin", "given": "Matthew", "initials": "M"}, {"family": "Einardottir", "given": "Sigrun", "initials": "S"}, {"family": "Lepretre", "given": "Sophie Ducastelle", "initials": "SD"}, {"family": "Maertens", "given": "Johan", "initials": "J"}, {"family": "Campos", "given": "Antonio", "initials": "A"}, {"family": "Metafuni", "given": "Elisabetta", "initials": "E"}, {"family": "Pichler", "given": "Herbert", "initials": "H"}, {"family": "Folber", "given": "Frantisek", "initials": "F"}, {"family": "Solano", "given": "Carlos", "initials": "C"}, {"family": "Nicholson", "given": "Emma", "initials": "E"}, {"family": "Y\u00fcksel", "given": "Meltem Kurt", "initials": "MK"}, {"family": "Carlson", "given": "Kristina", "initials": "K"}, {"family": "Aguado", "given": "Beatriz", "initials": "B"}, {"family": "Besley", "given": "Caroline", "initials": "C"}, {"family": "Byrne", "given": "Jenny", "initials": "J"}, {"family": "Heras", "given": "Immaculada", "initials": "I"}, {"family": "Dignan", "given": "Fiona", "initials": "F"}, {"family": "Kr\u00f6ger", "given": "Nicolaus", "initials": "N"}, {"family": "Robin", "given": "Christine", "initials": "C"}, {"family": "Khan", "given": "Anjum", "initials": "A"}, {"family": "Lenhoff", "given": "Stig", "initials": "S"}, {"family": "Grassi", "given": "Anna", "initials": "A"}, {"family": "Dobsinska", "given": "Veronika", "initials": "V"}, {"family": "Miranda", "given": "Nuno", "initials": "N"}, {"family": "Jimenez", "given": "Maria-Jose", "initials": "MJ"}, {"family": "Yonal-Hindilerden", "given": "Ipek", "initials": "I"}, {"family": "Wilson", "given": "Keith", "initials": "K"}, {"family": "Averbuch", "given": "Dina", "initials": "D"}, {"family": "Cesaro", "given": "Simone", "initials": "S"}, {"family": "Xhaard", "given": "Alienor", "initials": "A"}, {"family": "Knelange", "given": "Nina", "initials": "N"}, {"family": "Styczynski", "given": "Jan", "initials": "J"}, {"family": "Mikulska", "given": "Malgorzata", "initials": "M"}, {"family": "de la Camara", "given": "Rafael", "initials": "R"}], "type": "journal article", "published": "2023-03-07", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "14", "pages": "1125824", "issn-l": "1664-3224"}, "abstract": "COVID-19 has been associated with high morbidity and mortality in allogeneic hematopoietic stem cell transplant (allo-HCT) recipients.\n\nThis study reports on 986 patients reported to the EBMT registry during the first 29 months of the pandemic.\n\nThe median age was 50.3 years (min - max; 1.0 - 80.7). The median time from most recent HCT to diagnosis of COVID-19 was 20 months (min - max; 0.0 - 383.9). The median time was 19.3 (0.0 - 287.6) months during 2020, 21.2 (0.1 - 324.5) months during 2021, and 19.7 (0.1 - 383.9) months during 2022 (p = NS). 145/986 (14.7%) patients died; 124 (12.6%) due to COVID-19 and 21 of other causes. Only 2/204 (1%) fully vaccinated patients died from COVID-19. There was a successive improvement in overall survival over time. In multivariate analysis, increasing age (p<.0001), worse performance status (p<.0001), contracting COVID-19 within the first 30 days (p<.0001) or 30 - 100 days after HCT (p=.003), ongoing immunosuppression (p=.004), pre-existing lung disease (p=.003), and recipient CMV seropositivity (p=.004) had negative impact on overall survival while patients contracting COVID-19 in 2020 (p<.0001) or 2021 (p=.027) had worse overall survival than patients with COVID-19 diagnosed in 2022.\n\nAlthough the outcome of COVID-19 has improved, patients having risk factors were still at risk for severe COVID-19 including death.", "doi": "10.3389/fimmu.2023.1125824", "pmid": "36960069", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10028143"}], "notes": [], "created": "2023-04-21T16:04:40.764Z", "modified": "2023-04-21T16:04:40.779Z"}, {"entity": "publication", "iuid": "65f05be676d24d99a94289740229f478", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65f05be676d24d99a94289740229f478.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65f05be676d24d99a94289740229f478"}}, "title": "Dissection of Antibody Responses of Gam-COVID-Vac-Vaccinated Subjects Suggests Involvement of Epitopes Outside RBD in SARS-CoV-2 Neutralization.", "authors": [{"family": "Byazrova", "given": "Maria", "initials": "M"}, {"family": "Gattinger", "given": "Pia", "initials": "P", "orcid": "0000-0001-6724-8543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d470813c45d04ab295b0df1b02d7cf93.json"}}, {"family": "Astakhova", "given": "Ekaterina", "initials": "E"}, {"family": "Hofer", "given": "Gerhard", "initials": "G"}, {"family": "Khaitov", "given": "Musa", "initials": "M"}, {"family": "Filatov", "given": "Alexander", "initials": "A", "orcid": "0000-0002-6460-9427", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68803e957803458d89d969484dc7420b.json"}}, {"family": "Valenta", "given": "Rudolf", "initials": "R"}], "type": "journal article", "published": "2023-03-07", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "24", "issue": "6", "issn-l": null}, "abstract": "Millions of people have been vaccinated with Gam-COVID-Vac but fine specificities of induced antibodies have not been fully studied. Plasma from 12 na\u00efve and 10 coronavirus disease 2019 (COVID-19) convalescent subjects was obtained before and after two immunizations with Gam-COVID-Vac. Antibody reactivity in the plasma samples (n = 44) was studied on a panel of micro-arrayed recombinant folded and unfolded severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins and 46 peptides spanning the spike protein (S) and by immunoglobulin G (IgG) subclass enzyme-linked immunosorbent assay (ELISA). The ability of Gam-COVID-Vac-induced antibodies to inhibit binding of the receptor-binding domain (RBD) to its receptor angiotensin converting enzyme 2 (ACE2) was investigated in a molecular interaction assay (MIA). The virus-neutralizing capacity of antibodies was studied by the pseudo-typed virus neutralization test (pVNT) for Wuhan-Hu-1 and Omicron. We found that Gam-COVID-Vac vaccination induced significant increases of IgG1 but not of other IgG subclasses against folded S, spike protein subunit 1 (S1), spike protein subunit 2 (S2), and RBD in a comparable manner in na\u00efve and convalescent subjects. Virus neutralization was highly correlated with vaccination-induced antibodies specific for folded RBD and a novel peptide (i.e., peptide 12). Peptide 12 was located close to RBD in the N-terminal part of S1 and may potentially be involved in the transition of the pre- to post-fusion conformation of the spike protein. In summary, Gam-COVID-Vac vaccination induced S-specific IgG1 antibodies in naive and convalescent subjects in a comparable manner. Besides the antibodies specific for RBD, the antibodies induced against a peptide close to the N-terminus of RBD were also associated with virus-neutralization.", "doi": "10.3390/ijms24065104", "pmid": "36982183", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10049224"}, {"db": "pii", "key": "ijms24065104"}], "notes": [], "created": "2023-04-21T15:56:40.490Z", "modified": "2023-04-21T15:56:40.549Z"}, {"entity": "publication", "iuid": "2b3b7fc6d3ce4e78967d2aa8eb20b4ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b3b7fc6d3ce4e78967d2aa8eb20b4ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b3b7fc6d3ce4e78967d2aa8eb20b4ae"}}, "title": "Management of patients with advanced prostate cancer-metastatic and/or castration-resistant prostate cancer: report of the Advanced Prostate Cancer Consensus Conference (APCCC) 2022.", "authors": [{"family": "Gillessen", "given": "Silke", "initials": "S"}, {"family": "Bossi", "given": "Alberto", "initials": "A"}, {"family": "Davis", "given": "Ian D", "initials": "ID"}, {"family": "de Bono", "given": "Johann", "initials": "J"}, {"family": "Fizazi", "given": "Karim", "initials": "K"}, {"family": "James", "given": "Nicholas D", "initials": "ND"}, {"family": "Mottet", "given": "Nicolas", "initials": "N"}, {"family": "Shore", "given": "Neal", "initials": "N"}, {"family": "Small", "given": "Eric", "initials": "E"}, {"family": "Smith", "given": "Matthew", "initials": "M"}, {"family": "Sweeney", "given": "Christopher J", "initials": "CJ"}, {"family": "Tombal", "given": "Bertrand", "initials": "B"}, {"family": "Antonarakis", "given": "Emmanuel S", "initials": "ES"}, {"family": "Aparicio", "given": "Ana M", "initials": "AM"}, {"family": "Armstrong", "given": "Andrew J", "initials": "AJ"}, {"family": "Attard", "given": "Gerhardt", "initials": "G"}, {"family": "Beer", "given": "Tomasz M", "initials": "TM"}, {"family": "Beltran", "given": "Himisha", "initials": "H"}, {"family": "Bjartell", "given": "Anders", "initials": "A"}, {"family": "Blanchard", "given": "Pierre", "initials": "P"}, {"family": "Briganti", "given": "Alberto", "initials": "A"}, {"family": "Bristow", "given": "Rob G", "initials": "RG"}, {"family": "Bulbul", "given": "Muhammad", "initials": "M"}, {"family": "Caffo", "given": "Orazio", "initials": "O"}, {"family": "Castellano", "given": "Daniel", "initials": "D"}, {"family": "Castro", "given": "Elena", "initials": "E"}, {"family": "Cheng", "given": "Heather H", "initials": "HH"}, {"family": "Chi", "given": "Kim N", "initials": "KN"}, {"family": "Chowdhury", "given": "Simon", "initials": "S"}, {"family": "Clarke", "given": "Caroline S", "initials": "CS"}, {"family": "Clarke", "given": "Noel", "initials": "N"}, {"family": "Daugaard", "given": "Gedske", "initials": "G"}, {"family": "De Santis", "given": "Maria", "initials": "M"}, {"family": "Duran", "given": "Ignacio", "initials": "I"}, {"family": "Eeles", "given": "Ross", "initials": "R"}, {"family": "Efstathiou", "given": "Eleni", "initials": "E"}, {"family": "Efstathiou", "given": "Jason", "initials": "J"}, {"family": "Ekeke", "given": "Onyeanunam Ngozi", "initials": "ON"}, {"family": "Evans", "given": "Christopher P", "initials": "CP"}, {"family": "Fanti", "given": "Stefano", "initials": "S"}, {"family": "Feng", "given": "Felix Y", "initials": "FY"}, {"family": "Fonteyne", "given": "Valerie", "initials": "V"}, {"family": "Fossati", "given": "Nicola", "initials": "N"}, {"family": "Frydenberg", "given": "Mark", "initials": "M"}, {"family": "George", "given": "Dan", "initials": "D"}, {"family": "Gleave", "given": "Martin", "initials": "M"}, {"family": "Gravis", "given": "Gwenaelle", "initials": "G"}, {"family": "Halabi", "given": "Susan", "initials": "S"}, {"family": "Heinrich", "given": "Daniel", "initials": "D"}, {"family": "Herrmann", "given": "Ken", "initials": "K"}, {"family": "Higano", "given": "Celestia", "initials": "C"}, {"family": "Hofman", "given": "Michael S", "initials": "MS"}, {"family": "Horvath", "given": "Lisa G", "initials": "LG"}, {"family": "Hussain", "given": "Maha", "initials": "M"}, {"family": "Jereczek-Fossa", "given": "Barbara A", "initials": "BA"}, {"family": "Jones", "given": "Rob", "initials": "R"}, {"family": "Kanesvaran", "given": "Ravindran", "initials": "R"}, {"family": "Kellokumpu-Lehtinen", "given": "Pirkko-Liisa", "initials": "PL"}, {"family": "Khauli", "given": "Raja B", "initials": "RB"}, {"family": "Klotz", "given": "Laurence", "initials": "L"}, {"family": "Kramer", "given": "Gero", "initials": "G"}, {"family": "Leibowitz", "given": "Raja", "initials": "R"}, {"family": "Logothetis", "given": "Christopher", "initials": "C"}, {"family": "Mahal", "given": "Brandon", "initials": "B"}, {"family": "Maluf", "given": "Fernando", "initials": "F"}, {"family": "Mateo", "given": "Joaquin", "initials": "J"}, {"family": "Matheson", "given": "David", "initials": "D"}, {"family": "Mehra", "given": "Niven", "initials": "N"}, {"family": "Merseburger", "given": "Axel", "initials": "A"}, {"family": "Morgans", "given": "Alicia K", "initials": "AK"}, {"family": "Morris", "given": "Michael J", "initials": "MJ"}, {"family": "Mrabti", "given": "Hind", "initials": "H"}, {"family": "Mukherji", "given": "Deborah", "initials": "D"}, {"family": "Murphy", "given": "Declan G", "initials": "DG"}, {"family": "Murthy", "given": "Vedang", "initials": "V"}, {"family": "Nguyen", "given": "Paul L", "initials": "PL"}, {"family": "Oh", "given": "William K", "initials": "WK"}, {"family": "Ost", "given": "Piet", "initials": "P"}, {"family": "O'Sullivan", "given": "Joe M", "initials": "JM"}, {"family": "Padhani", "given": "Anwar R", "initials": "AR"}, {"family": "Pezaro", "given": "Carmel J", "initials": "CJ"}, {"family": "Poon", "given": "Darren M C", "initials": "DMC"}, {"family": "Pritchard", "given": "Colin C", "initials": "CC"}, {"family": "Rabah", "given": "Danny M", "initials": "DM"}, {"family": "Rathkopf", "given": "Dana", "initials": "D"}, {"family": "Reiter", "given": "Robert E", "initials": "RE"}, {"family": "Rubin", "given": "Mark A", "initials": "MA"}, {"family": "Ryan", "given": "Charles J", "initials": "CJ"}, {"family": "Saad", "given": "Fred", "initials": "F"}, {"family": "Sade", "given": "Juan Pablo", "initials": "JP"}, {"family": "Sartor", "given": "Oliver", "initials": "O"}, {"family": "Scher", "given": "Howard I", "initials": "HI"}, {"family": "Sharifi", "given": "Nima", "initials": "N"}, {"family": "Skoneczna", "given": "Iwona", "initials": "I"}, {"family": "Soule", "given": "Howard", "initials": "H"}, {"family": "Spratt", "given": "Daniel E", "initials": "DE"}, {"family": "Srinivas", "given": "Sandy", "initials": "S"}, {"family": "Sternberg", "given": "Cora N", "initials": "CN"}, {"family": "Steuber", "given": "Thomas", "initials": "T"}, {"family": "Suzuki", "given": "Hiroyoshi", "initials": "H"}, {"family": "Sydes", "given": "Matthew R", "initials": "MR"}, {"family": "Taplin", "given": "Mary-Ellen", "initials": "ME"}, {"family": "Tilki", "given": "Derya", "initials": "D"}, {"family": "T\u00fcrkeri", "given": "Levent", "initials": "L"}, {"family": "Turco", "given": "Fabio", "initials": "F"}, {"family": "Uemura", "given": "Hiroji", "initials": "H"}, {"family": "Uemura", "given": "Hirotsugu", "initials": "H"}, {"family": "\u00dcr\u00fcn", "given": "Y\u00fcksel", "initials": "Y"}, {"family": "Vale", "given": "Claire L", "initials": "CL"}, {"family": "van Oort", "given": "Inge", "initials": "I"}, {"family": "Vapiwala", "given": "Neha", "initials": "N"}, {"family": "Walz", "given": "Jochen", "initials": "J"}, {"family": "Yamoah", "given": "Kosj", "initials": "K"}, {"family": "Ye", "given": "Dingwei", "initials": "D"}, {"family": "Yu", "given": "Evan Y", "initials": "EY"}, {"family": "Zapatero", "given": "Almudena", "initials": "A"}, {"family": "Zilli", "given": "Thomas", "initials": "T"}, {"family": "Omlin", "given": "Aurelius", "initials": "A"}], "type": "journal article", "published": "2023-03-03", "journal": {"title": "Eur J Cancer", "issn": "1879-0852", "volume": "185", "pages": "178-215", "issn-l": "0959-8049"}, "abstract": "Innovations in imaging and molecular characterisation together with novel treatment options have improved outcomes in advanced prostate cancer. However, we still lack high-level evidence in many areas relevant to making management decisions in daily clinical practise. The 2022 Advanced Prostate Cancer Consensus Conference (APCCC 2022) addressed some questions in these areas to supplement guidelines that mostly are based on level 1 evidence.\n\nTo present the voting results of the APCCC 2022.\n\nThe experts voted on controversial questions where high-level evidence is mostly lacking: locally advanced prostate cancer; biochemical recurrence after local treatment; metastatic hormone-sensitive, non-metastatic, and metastatic castration-resistant prostate cancer; oligometastatic prostate cancer; and managing side effects of hormonal therapy. A panel of 105 international prostate cancer experts voted on the consensus questions.\n\nThe panel voted on 198 pre-defined questions, which were developed by 117 voting and non-voting panel members prior to the conference following a modified Delphi process. A total of 116 questions on metastatic and/or castration-resistant prostate cancer are discussed in this manuscript. In 2022, the voting was done by a web-based survey because of COVID-19 restrictions.\n\nThe voting reflects the expert opinion of these panellists and did not incorporate a standard literature review or formal meta-analysis. The answer options for the consensus questions received varying degrees of support from panellists, as reflected in this article and the detailed voting results are reported in the supplementary material. We report here on topics in metastatic, hormone-sensitive prostate cancer (mHSPC), non-metastatic, castration-resistant prostate cancer (nmCRPC), metastatic castration-resistant prostate cancer (mCRPC), and oligometastatic and oligoprogressive prostate cancer.\n\nThese voting results in four specific areas from a panel of experts in advanced prostate cancer can help clinicians and patients navigate controversial areas of management for which high-level evidence is scant or conflicting and can help research funders and policy makers identify information gaps and consider what areas to explore further. However, diagnostic and treatment decisions always have to be individualised based on patient characteristics, including the extent and location of disease, prior treatment(s), co-morbidities, patient preferences, and treatment recommendations and should also incorporate current and emerging clinical evidence and logistic and economic factors. Enrolment in clinical trials is strongly encouraged. Importantly, APCCC 2022 once again identified important gaps where there is non-consensus and that merit evaluation in specifically designed trials.\n\nThe Advanced Prostate Cancer Consensus Conference (APCCC) provides a forum to discuss and debate current diagnostic and treatment options for patients with advanced prostate cancer. The conference aims to share the knowledge of international experts in prostate cancer with healthcare providers worldwide. At each APCCC, an expert panel votes on pre-defined questions that target the most clinically relevant areas of advanced prostate cancer treatment for which there are gaps in knowledge. The results of the voting provide a practical guide to help clinicians discuss therapeutic options with patients and their relatives as part of shared and multidisciplinary decision-making. This report focuses on the advanced setting, covering metastatic hormone-sensitive prostate cancer and both non-metastatic and metastatic castration-resistant prostate cancer.\n\nReport of the results of APCCC 2022 for the following topics: mHSPC, nmCRPC, mCRPC, and oligometastatic prostate cancer.\n\nAt APCCC 2022, clinically important questions in the management of advanced prostate cancer management were identified and discussed, and experts voted on pre-defined consensus questions. The report of the results for metastatic and/or castration-resistant prostate cancer is summarised here.", "doi": "10.1016/j.ejca.2023.02.018", "pmid": "37003085", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0959-8049(23)00110-7"}], "notes": [], "created": "2023-04-20T17:40:52.720Z", "modified": "2023-04-20T17:40:52.732Z"}, {"entity": "publication", "iuid": "7af7ee094d4a43fdb14612045b40587b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7af7ee094d4a43fdb14612045b40587b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7af7ee094d4a43fdb14612045b40587b"}}, "title": "Optimising conditions and environments for digital participation in later life: A macro-meso-micro framework of partnership-building.", "authors": [{"family": "Reuter", "given": "Arlind", "initials": "A"}, {"family": "Xu", "given": "Wenqian", "initials": "W"}, {"family": "Iwarsson", "given": "Susanne", "initials": "S"}, {"family": "Olsson", "given": "Tobias", "initials": "T"}, {"family": "Schmidt", "given": "Steven M", "initials": "SM"}], "type": "journal article", "published": "2023-03-02", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "14", "pages": "1107024", "issn-l": "1664-1078"}, "abstract": "The ongoing digitalisation of societies, exacerbated by the COVID-19 pandemic, has led to increased efforts to ensure the digital inclusion of older adults. Digital inclusion strategies throughout the COVID-19 pandemic predominantly focused on increasing access and basic digital literacy of Information and Communication Technologies (ICTs) for all members of society. Older adults, who are more likely to experience digital exclusion, are amongst the target groups of digital inclusion strategies. We propose that beyond digital inclusion, there is a need to focus on digital participation and optimise opportunities for everyone to participate in communities and society in post-pandemic times. Creative digital skills are the foundation of digital participation and can lead to a variety of contributions. Digital participation offers conditions that support agency and active contributions in a digitalised society. Taking macro-, meso-, and micro-level enablers of digital participation in later life into account, we argue for the establishment and implementation of multi-layered and multisectoral partnerships that address environmental factors (including social and physical dimensions) of digital participation and create opportunities for diverse, meaningful and fulfilling engagement with ICTs in later life. The partnership approach can be used in designing and implementing digital participation programmes and should be further evaluated against the needs and lived experiences of older individuals. Foresighted research is needed to investigate key factors of effective partnerships for optimising environments for digital participation in later life.", "doi": "10.3389/fpsyg.2023.1107024", "pmid": "36936014", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10017487"}], "notes": [], "created": "2023-04-21T16:10:59.315Z", "modified": "2023-04-21T16:10:59.331Z"}, {"entity": "publication", "iuid": "bec28b7a63e44bd58fc76b207fe907d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bec28b7a63e44bd58fc76b207fe907d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bec28b7a63e44bd58fc76b207fe907d5"}}, "title": "Prevalence and Characteristics Associated With Post-COVID-19 Condition Among Nonhospitalized Adolescents and Young Adults.", "authors": [{"family": "Selvakumar", "given": "Joel", "initials": "J"}, {"family": "Havdal", "given": "Lise Beier", "initials": "LB"}, {"family": "Drevvatne", "given": "Martin", "initials": "M"}, {"family": "Brodwall", "given": "Elias Myrstad", "initials": "EM"}, {"family": "Lund Berven", "given": "Lise", "initials": "L"}, {"family": "Stiansen-Sonerud", "given": "Tonje", "initials": "T"}, {"family": "Einvik", "given": "Gunnar", "initials": "G"}, {"family": "Leegaard", "given": "Truls Michael", "initials": "TM"}, {"family": "Tjade", "given": "Trygve", "initials": "T"}, {"family": "Michelsen", "given": "Annika E", "initials": "AE"}, {"family": "Mollnes", "given": "Tom Eirik", "initials": "TE"}, {"family": "Lund-Johansen", "given": "Fridtjof", "initials": "F"}, {"family": "Holm\u00f8y", "given": "Trygve", "initials": "T"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Sandler", "given": "Carolina X", "initials": "CX"}, {"family": "Cvejic", "given": "Erin", "initials": "E"}, {"family": "Lloyd", "given": "Andrew R", "initials": "AR"}, {"family": "Wyller", "given": "Vegard Bruun Bratholm", "initials": "VBB"}], "type": "journal article", "published": "2023-03-01", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "volume": "6", "issue": "3", "pages": "e235763", "issn-l": null}, "abstract": "The prevalence and baseline risk factors of post-COVID-19 condition (PCC) remain unresolved among the large number of young people who experienced mild COVID-19.\n\nTo determine the point prevalence of PCC 6 months after the acute infection, to determine the risk of development of PCC adjusted for possible confounders, and to explore a broad range of potential risk factors.\n\nThis cohort study included nonhospitalized individuals from 2 counties in Norway between ages 12 and 25 years who underwent reverse transcription-polymerase chain reaction (RT-PCR) testing. At the early convalescent stage and at 6-month follow-up, participants underwent a clinical examination; pulmonary, cardiac, and cognitive functional testing; immunological and organ injury biomarker analyses; and completion of a questionnaire. Participants were classified according to the World Health Organization case definition of PCC at follow-up. Association analyses of 78 potential risk factors were performed.\n\nSARS-CoV-2 infection.\n\nThe point prevalence of PCC 6 months after RT-PCR testing in the SARS-CoV-2-positive and SARS-CoV-2-negative groups, and the risk difference with corresponding 95% CIs.\n\nA total of 404 individuals testing positive for SARS-CoV-2 and 105 individuals testing negative were enrolled (194 male [38.1%]; 102 non-European [20.0%] ethnicity). A total of 22 of the SARS-CoV-2-positive and 4 of the SARS-CoV-2-negative individuals were lost to follow-up, and 16 SARS-CoV-2-negative individuals were excluded due to SARS-CoV-2 infection in the observational period. Hence, 382 SARS-CoV-2-positive participants (mean [SD] age, 18.0 [3.7] years; 152 male [39.8%]) and 85 SARS-CoV-2-negative participants (mean [SD] age, 17.7 [3.2] years; 31 male [36.5%]) could be evaluated. The point prevalence of PCC at 6 months was 48.5% in the SARS-CoV-2-positive group and 47.1% in the control group (risk difference, 1.5%; 95% CI, -10.2% to 13.1%). SARS-CoV-2 positivity was not associated with the development of PCC (relative risk [RR], 1.06; 95% CI, 0.83 to 1.37; final multivariable model utilizing modified Poisson regression). The main risk factor for PCC was symptom severity at baseline (RR, 1.41; 95% CI, 1.27-1.56). Low physical activity (RR, 0.96; 95% CI, 0.92-1.00) and loneliness (RR, 1.01; 95% CI, 1.00-1.02) were also associated, while biological markers were not. Symptom severity correlated with personality traits.\n\nThe persistent symptoms and disability that characterize PCC are associated with factors other than SARS-CoV-2 infection, including psychosocial factors. This finding raises questions about the utility of the World Health Organization case definition and has implications for the planning of health care services as well as for further research on PCC.", "doi": "10.1001/jamanetworkopen.2023.5763", "pmid": "36995712", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC10064252"}, {"db": "pii", "key": "2802893"}], "notes": [], "created": "2023-04-21T15:52:21.113Z", "modified": "2023-04-21T15:53:16.684Z"}, {"entity": "publication", "iuid": "81e376782a4948a7aa3e7bdc7c9c1609", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/81e376782a4948a7aa3e7bdc7c9c1609.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/81e376782a4948a7aa3e7bdc7c9c1609"}}, "title": "Frequent use of IGHV3-30-3 in SARS-CoV-2 neutralizing antibody responses.", "authors": [{"family": "Pushparaj", "given": "Pradeepa", "initials": "P"}, {"family": "Nicoletto", "given": "Andrea", "initials": "A"}, {"family": "Dopico", "given": "Xaquin Castro", "initials": "XC"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Kim", "given": "Sungyong", "initials": "S"}, {"family": "Ekstr\u00f6m", "given": "Simon", "initials": "S"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Corcoran", "given": "Martin", "initials": "M"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}], "type": "journal article", "published": "2023-03-01", "journal": {"title": "Front Virol", "issn": "2673-818X", "issn-l": null, "volume": "3", "issue": null, "pages": "1128253"}, "abstract": "The antibody response to SARS-CoV-2 shows biased immunoglobulin heavy chain variable (IGHV) gene usage, allowing definition of genetic signatures for some classes of neutralizing antibodies. We investigated IGHV gene usage frequencies by sorting spike-specific single memory B cells from individuals infected with SARS-CoV-2 early in the pandemic. From two study participants and 703 spikespecific B cells, the most used genes were IGHV1-69, IGHV3-30-3, and IGHV3-30. Here, we focused on the IGHV3-30 group of genes and an IGHV3-30-3-using ultrapotent neutralizing monoclonal antibody, CAB-F52, which displayed broad neutralizing activity also in its germline-reverted form. IGHV3-30-3 is encoded by a region of the IGH locus that is highly variable at both the allelic and structural levels. Using personalized IG genotyping, we found that 4 of 14 study participants lacked the IGHV3-30-3 gene on both chromosomes, raising the question if other, highly similar IGHV genes could substitute for IGHV3-30-3 in persons lacking this gene. In the context of CAB-F52, we found that none of the tested IGHV3-33 alleles, but several IGHV3-30 alleles could substitute for IGHV3-30-3, suggesting functional redundancy between the highly homologous IGHV3-30 and IGHV3-30-3 genes for this antibody.", "doi": "10.3389/fviro.2023.1128253", "pmid": "37041983", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC7614418"}, {"db": "URL", "key": "https://www.frontiersin.org/articles/10.3389/fviro.2023.1128253/full#supplementary-material", "description": "https://www.frontiersin.org/articles/10.3389/fviro.2023.1128253/full#supplementary-material"}], "notes": [], "created": "2023-04-12T17:02:23.880Z", "modified": "2023-04-12T17:03:49.485Z"}, {"entity": "publication", "iuid": "66de20f884d741cf9c6fe15b97766203", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66de20f884d741cf9c6fe15b97766203.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66de20f884d741cf9c6fe15b97766203"}}, "title": "Tissue factor activity of small and large extracellular vesicles in different diseases.", "authors": [{"family": "Sachetto", "given": "Ana T A", "initials": "ATA"}, {"family": "Archibald", "given": "Sierra J", "initials": "SJ"}, {"family": "Hisada", "given": "Yohei", "initials": "Y"}, {"family": "Rosell", "given": "Axel", "initials": "A"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "van Es", "given": "Nick", "initials": "N"}, {"family": "Nieuwland", "given": "Rienk", "initials": "R"}, {"family": "Campbell", "given": "Robert A", "initials": "RA"}, {"family": "Middleton", "given": "Elizabeth A", "initials": "EA"}, {"family": "Rondina", "given": "Matthew T", "initials": "MT"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "Res Pract Thromb Haemost", "issn": "2475-0379", "volume": "7", "issue": "3", "pages": "100124", "issn-l": null}, "abstract": "Circulating procoagulant extracellular vesicles (EVs) are increased in diseases, such as cancer, sepsis, and COVID-19. EV tissue factor (TF) activity is associated with disseminated intravascular coagulation in sepsis and venous thrombosis in patients with pancreatic cancer and COVID-19. EVs are commonly isolated by centrifugation at \u223c20,000 g.\n\nIn this study, we analyzed the TF activity of 2 EV populations enriched for large and small EVs in patients with either sepsis, pancreatic cancer, or COVID-19.\n\nEVs were isolated from plasma by sequential centrifugation at 20,000 g (large EVs, LEVs) and then 100,000 g (small EVs, SEVs). We analyzed EVs from plasma prepared from whole blood samples from healthy individuals with or without lipopolysaccharide (LPS) stimulation as well as EVs from plasma samples from patients with either sepsis, pancreatic cancer, or COVID-19. TF-dependent (EV-TF activity) and TF-independent factor Xa (FXa) generation of the EVs was measured.\n\nLPS increased EV-TF activity in LEVs but not SEVs. Similarly, in 2 patients with sepsis who had EV-TF activity above the background of the assay we observed EV-TF activity in LEVs but not SEVs. Patients with pancreatic cancer or COVID-19 had circulating EV-TF activity in both LEVs and SEVs.\n\nWe recommend that EVs are isolated from plasma from patients by centrifugation at 100,000 g rather than 20,000 g to obtain a more accurate measure of levels of circulating EV-TF activity.", "doi": "10.1016/j.rpth.2023.100124", "pmid": "37012986", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10015082"}, {"db": "pii", "key": "S2475-0379(23)00095-X"}], "notes": [], "created": "2023-04-12T16:53:04.397Z", "modified": "2023-04-20T17:35:04.601Z"}, {"entity": "publication", "iuid": "5c1c1d407c184180b0f336a10852eb68", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c1c1d407c184180b0f336a10852eb68.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c1c1d407c184180b0f336a10852eb68"}}, "title": "The effect of time spent sitting and excessive gaming on the weight status, and perceived weight stigma among Taiwanese young adults.", "authors": [{"family": "Kamolthip", "given": "Ruckwongpatr", "initials": "R"}, {"family": "Yang", "given": "Yung-Ning", "initials": "YN"}, {"family": "Latner", "given": "Janet D", "initials": "JD"}, {"family": "O'Brien", "given": "Kerry S", "initials": "KS"}, {"family": "Chang", "given": "Yen-Ling", "initials": "YL"}, {"family": "Lin", "given": "Chien-Chin", "initials": "CC"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": "9", "issue": "3", "pages": "e14298", "issn-l": null}, "abstract": "During the COVID-19 pandemic, physical inactivity and sedentary behaviors (i.e., longer sitting time and excessive gaming) increased because governments across the globe adopted stringent mitigation strategies such as social distancing and lockdowns to curb the spread of the virus. Excessive gaming was one of the coping mechanisms used to deal with the pressure associated with the pandemic. Moreover, perceived weight stigma (PWS) and weight status became more salient concerns among young adults during the COVID-19 pandemic. The current study sought to investigate the relationship between time spent sitting, excessive gaming, weight status, and PWS of Taiwanese Young adults. Additionally, weight status and PWS were examined as mediators between both sedentary behaviors.\n\nThis cross-sectional study involved 600 participants who were recruited through Taiwan universities. All participants completed a demographic questionnaire (including weight and height) and self-report measures including the International Physical Activity Questionnaire short form (IPAQ-SF), the Perceived Weight Stigma Scale (PWSS), and the Internet Gaming Disorder Scale-short form (IGDS9-SF). PROCESS model was performed to test the potential mediation roles of weight status and PWS. Moreover, we categorized participants into two groups based on the sitting-time item in the IPAQ-SF: students whose sitting time was less than 8 h daily, and those more than 8 h daily.\n\nThe group that had less than 8 h had significantly higher PWS and IGDS9-SF scores than the other group. Sitting time was negatively associated with weight status, PWS, and IGDS9-SF. Additionally, we found a significantly direct effect between time spent sitting and excessive gaming. Both weight status and PWS were significant mediators in the association between time spent sitting and excessive gaming.Conclusions: The present study demonstrated important negative correlates of excessive sedentary behaviors. Prevention efforts should focus on promoting physical activity and providing information to decrease sedentary behavior among university students.", "doi": "10.1016/j.heliyon.2023.e14298", "pmid": "36938463", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10018563"}, {"db": "pii", "key": "S2405-8440(23)01505-0"}], "notes": [], "created": "2023-04-21T16:09:37.800Z", "modified": "2023-04-21T16:09:37.814Z"}, {"entity": "publication", "iuid": "befbcb1b88f84f8ab93f91ad0015f19e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/befbcb1b88f84f8ab93f91ad0015f19e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/befbcb1b88f84f8ab93f91ad0015f19e"}}, "title": "Prevalence of ongoing or previous SARS-CoV-2 infection among dental personnel - the Swedish experience.", "authors": [{"family": "Fredriksson", "given": "Lars", "initials": "L"}, {"family": "Cederlund", "given": "Andreas", "initials": "A"}, {"family": "Murray", "given": "My", "initials": "M"}, {"family": "Jansson", "given": "Leif", "initials": "L"}, {"family": "Skott", "given": "Pia", "initials": "P"}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "Acta Odontol Scand", "issn": "1502-3850", "pages": "119-123", "volume": "81", "issue": "2", "issn-l": null}, "abstract": "The seroprevalence of SARS-CoV-2 infection was approximately similar to that in healthcare personnel, and approximately equal compared to that in the general population.\n\nWe carried out an observational cohort study from March to June 2020, including 341 employees randomly selected from Public Dental Service in the County of Stockholm. The primary outcome variable was the prevalence of SARS-CoV-2 RNA and/or antibodies against SARS-CoV-2. Throat samples were analysed for SARS-CoV-2 RNA. Venous blood was collected to detect antibodies against SARS-CoV-2 using the Luminex analysis tool (immunoassay) and ELISA. Logistic regression analysis was used to compare the independent groups and calculate the unadjusted odds ratio.\n\nTo investigate whether personnel in a public dental clinic had a higher frequency of ongoing or previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection than hospital healthcare workers or the general public in Stockholm during weeks 23-25 in 2020.\n\nThe mean age of the participants was 50.1 years, and 11.7% were male. The prevalence of SARS-CoV-2 RNA and/or antibodies against SARS-CoV-2 was 12.0% (95% confidence interval 8.8-16.0). Among them, 82.5% reported symptoms and 85.4% were on sick-leave between March and June 2020.", "doi": "10.1080/00016357.2022.2095023", "pmid": "35771959", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-19T05:28:40.708Z", "modified": "2023-02-27T17:23:18.839Z"}, {"entity": "publication", "iuid": "a6335c7e323041f087c9920a70e0af66", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6335c7e323041f087c9920a70e0af66.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6335c7e323041f087c9920a70e0af66"}}, "title": "Postmortem lung and heart examination of COVID-19 patients in a case series from Jordan.", "authors": [{"family": "Abdaljaleel", "given": "Maram", "initials": "M"}, {"family": "Tawalbeh", "given": "Isra", "initials": "I"}, {"family": "Sallam", "given": "Malik", "initials": "M"}, {"family": "Hani", "given": "Amjad Bani", "initials": "AB"}, {"family": "Al-Abdallat", "given": "Imad M", "initials": "IM"}, {"family": "Omari", "given": "Baheth Al", "initials": "BA"}, {"family": "Al-Mustafa", "given": "Sahar", "initials": "S"}, {"family": "Abder-Rahman", "given": "Hasan", "initials": "H"}, {"family": "Abbas", "given": "Adnan Said", "initials": "AS"}, {"family": "Zureigat", "given": "Mahmoud", "initials": "M"}, {"family": "Al-Abbadi", "given": "Mousa A", "initials": "MA"}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "J Pathol Transl Med", "issn": "2383-7837", "volume": "57", "issue": "2", "pages": "102-112", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) has emerged as a pandemic for more than 2 years. Autopsy examination is an invaluable tool to understand the pathogenesis of emerging infections and their consequent mortalities. The aim of the current study was to present the lung and heart pathological findings of COVID-19-positive autopsies performed in Jordan.\n\nThe study involved medicolegal cases, where the cause of death was unclear and autopsy examination was mandated by law. We included the clinical and pathologic findings of routine gross and microscopic examination of cases that were positive for COVID-19 at time of death. Testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was confirmed through molecular detection by real-time polymerase chain reaction, serologic testing for IgM and electron microscope examination of lung samples.\n\nSeventeen autopsies were included, with male predominance (76.5%), Jordanians (70.6%), and 50 years as the mean age at time of death. Nine out of 16 cases (56.3%) had co-morbidities, with one case lacking such data. Histologic examination of lung tissue revealed diffuse alveolar damage in 13/17 cases (76.5%), and pulmonary microthrombi in 8/17 cases (47.1%). Microscopic cardiac findings were scarcely detected. Two patients died as a direct result of acute cardiac disease with limited pulmonary findings.\n\nThe detection of SARS-CoV-2 in postmortem examination can be an incidental or contributory finding which highlights the value of autopsy examination to determine the exact cause of death in controversial cases.", "doi": "10.4132/jptm.2023.01.30", "pmid": "36950812", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10028009"}, {"db": "pii", "key": "jptm.2023.01.30"}], "notes": [], "created": "2023-04-21T16:06:18.219Z", "modified": "2023-04-21T16:06:18.249Z"}, {"entity": "publication", "iuid": "b7acd11c71a747c680184bf65a33eab4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b7acd11c71a747c680184bf65a33eab4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b7acd11c71a747c680184bf65a33eab4"}}, "title": "Ending tuberculosis in Europe - resetting the course in the post-COVID-19 era.", "authors": [{"family": "Ammon", "given": "Andrea", "initials": "A"}, {"family": "Kluge", "given": "Hans", "initials": "H"}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "28", "issue": "12", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2023.28.12.2300164", "pmid": "36951785", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10037663"}], "notes": [], "created": "2023-04-21T16:05:58.119Z", "modified": "2023-04-21T16:05:58.133Z"}, {"entity": "publication", "iuid": "bc340dba244547368876643044926ea9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bc340dba244547368876643044926ea9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bc340dba244547368876643044926ea9"}}, "title": "Clinical Psychology and the COVID-19 Pandemic: A Mixed Methods Survey Among Members of the European Association of Clinical Psychology and Psychological Treatment (EACLIPT).", "authors": [{"family": "Asbrand", "given": "Julia", "initials": "J", "orcid": "0000-0003-2740-6070", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ec60c3248048dc9d2d6f6295532c82.json"}}, {"family": "Gerdes", "given": "Samantha", "initials": "S", "orcid": "0009-0005-5352-2878", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5baa03eb311c425abe9e7a6242f22a1b.json"}}, {"family": "Breedvelt", "given": "Josefien", "initials": "J", "orcid": "0000-0003-1864-1861", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ef1cfcb7b74c2ab3cb66fb32c3ef94.json"}}, {"family": "Guidi", "given": "Jenny", "initials": "J", "orcid": "0000-0001-6815-2738", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/723aedb65169433cb51b99314509c977.json"}}, {"family": "Hirsch", "given": "Colette", "initials": "C", "orcid": "0000-0003-3579-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/23f55b6faf8d4c8884beeb5bfabb26b2.json"}}, {"family": "Maercker", "given": "Andreas", "initials": "A", "orcid": "0000-0001-6925-3266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15a03c24689741fb919740b0e4dda05c.json"}}, {"family": "Douilliez", "given": "C\u00e9line", "initials": "C", "orcid": "0000-0001-8912-885X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d387fee028b944c9829f6053498b629e.json"}}, {"family": "Andersson", "given": "Gerhard", "initials": "G", "orcid": "0000-0003-4753-6745", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b4074e5f32e453598de03ffcd897f67.json"}}, {"family": "Debban\u00e9", "given": "Martin", "initials": "M", "orcid": "0000-0002-4677-8753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/974ab9e42dd84d5f8bc7968dadd26022.json"}}, {"family": "Cieslak", "given": "Roman", "initials": "R", "orcid": "0000-0002-2413-5343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc9c0ccb0bbb4952b0ef1902d6a92a37.json"}}, {"family": "Rief", "given": "Winfried", "initials": "W", "orcid": "0000-0002-7019-2250", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9e36a5b17d640ec8f3f3f4c185a521e.json"}}, {"family": "Bockting", "given": "Claudi", "initials": "C", "orcid": "0000-0002-9220-9244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/281735678af94747b23f8f95cf1696bf.json"}}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "Clin Psychol Eur", "issn": "2625-3410", "volume": "5", "issue": "1", "pages": "e8109", "issn-l": null}, "abstract": "The COVID-19 pandemic has affected people globally both physically and psychologically. The increased demands for mental health interventions provided by clinical psychologists, psychotherapists and mental health care professionals, as well as the rapid change in work setting (e.g., from face-to-face to video therapy) has proven challenging. The current study investigates European clinical psychologists and psychotherapists' views on the changes and impact on mental health care that occurred due to the COVID-19 pandemic. It further aims to explore individual and organizational processes that assist clinical psychologists' and psychotherapists' in their new working conditions, and understand their needs and priorities.\n\nMembers of the European Association of Clinical Psychology and Psychological Treatment (EACLIPT) were invited (N = 698) to participate in a survey with closed and open questions covering their experiences during the first wave of the pandemic from June to September 2020. Participants (n = 92) from 19 European countries, mostly employed in universities or hospitals, completed the online survey.\n\nResults of qualitative and quantitative analyses showed that clinical psychologists and psychotherapists throughout the first wave of the COVID-19 pandemic managed to continue to provide treatments for patients who were experiencing emotional distress. The challenges (e.g., maintaining a working relationship through video treatment) and opportunities (e.g., more flexible working hours) of working through this time were identified.\n\nRecommendations for mental health policies and professional organizations are identified, such as clear guidelines regarding data security and workshops on conducting video therapy.", "doi": "10.32872/cpe.8109", "pmid": "37064999", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10103154"}, {"db": "pii", "key": "cpe.8109"}], "notes": [], "created": "2023-04-20T17:22:54.225Z", "modified": "2023-04-20T17:22:54.619Z"}, {"entity": "publication", "iuid": "92d1c3da53bc4fffb69d6dfba60ffa5d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/92d1c3da53bc4fffb69d6dfba60ffa5d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/92d1c3da53bc4fffb69d6dfba60ffa5d"}}, "title": "At-home sampling to meet geographical challenges for serological assessment of SARS-CoV-2 exposure in a rural region of northern Sweden, March to May 2021: a retrospective cohort study.", "authors": [{"family": "Bystr\u00f6m", "given": "Julia Wigren", "initials": "JW"}, {"family": "Vikstr\u00f6m", "given": "Linnea", "initials": "L"}, {"family": "Rosendal", "given": "Ebba", "initials": "E"}, {"family": "Gr\u00f6ning", "given": "Remigius", "initials": "R"}, {"family": "Gwon", "given": "Yong-Dae", "initials": "Y"}, {"family": "Nilsson", "given": "Emma", "initials": "E"}, {"family": "Sharma", "given": "Atin", "initials": "A"}, {"family": "Espaillat", "given": "Akbar", "initials": "A"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Puhar", "given": "Andrea", "initials": "A"}, {"family": "Cava", "given": "Felipe", "initials": "F"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Thunberg", "given": "Therese", "initials": "T"}, {"family": "Monsen", "given": "Tor", "initials": "T"}, {"family": "Elgh", "given": "Fredrik", "initials": "F"}, {"family": "Evander", "given": "Magnus", "initials": "M"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Forsell", "given": "Mattias Ne", "initials": "MN"}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "13", "pages": null}, "abstract": "BackgroundThe current SARS-CoV-2 pandemic has highlighted a need for easy and safe blood sampling in combination with accurate serological methodology. Venipuncture for testing is usually performed by trained staff at healthcare centres. Long travel distances to healthcare centres in rural regions may introduce a bias of testing towards relatively large communities with closer access. Rural regions are therefore often not represented in population-based data.AimThe aim of this retrospective cohort study was to develop and implement a strategy for at-home testing in a rural region of Sweden during spring 2021, and to evaluate its role to provide equal health care for its inhabitants.MethodsWe developed a sensitive method to measure antibodies to the S-protein of SARS-CoV-2 and optimised this assay for clinical use together with a strategy of at-home capillary blood sampling.ResultsWe demonstrated that our ELISA gave comparable results after analysis of capillary blood or serum from SARS-CoV-2-experienced individuals. We demonstrated stability of the assay under conditions that reflected temperature and humidity during winter or summer. By assessment of capillary blood samples from 4,122 individuals, we could show both feasibility of the strategy and that implementation shifted the geographical spread of testing in favour of rural areas.ConclusionImplementation of at-home sampling enabled citizens living in remote rural areas access to centralised and sensitive laboratory antibody tests. The strategy for testing used here could therefore enable disease control authorities to get rapid access to information concerning immunity to infectious diseases, even across vast geographical distance.", "doi": "10.2807/1560-7917.ES.2023.28.13.2200432", "pmid": "36995373", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null, "Funder: VR": null, "Funder: Vinnova": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC10064644"}], "notes": [], "created": "2023-04-12T16:46:21.928Z", "modified": "2023-04-12T16:57:03.602Z"}, {"entity": "publication", "iuid": "c156297880874d289605794386f2ba0f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c156297880874d289605794386f2ba0f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c156297880874d289605794386f2ba0f"}}, "title": "Arrival flight efficiency in pre- and post-Covid-19 pandemics.", "authors": [{"family": "Lemetti", "given": "Anastasia", "initials": "A"}, {"family": "Hardell", "given": "Henrik", "initials": "H"}, {"family": "Polishchuk", "given": "Tatiana", "initials": "T"}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "J Air Transp Manag", "issn": "1873-2089", "volume": "107", "pages": "102327", "issn-l": null}, "abstract": "Covid-19 pandemic affected aviation severely, resulting in unprecedented reduction of air traffic. While aviation is slowly re-gaining traffic volumes, we use the opportunity to study the arrival performance in the Terminal Maneuvering Area (TMA) in non-congested scenarios. Applying flight efficiency and environmental performance indicators (PIs) to the historical data of arrivals to Stockholm Arlanda and Gothenburg Landvetter airports, we discover noticeable inefficiencies, despite significant reduction of traffic intensity. We analyze the impact of such factors as weather and traffic intensity on arrival efficiency in isolated scenarios when only one factor dominates: isolated scenario with low traffic and isolated scenario with good weather conditions. Our analysis uncovers that weather has a stronger influence than traffic intensity on the vertical efficiency, while traffic intensity has stronger effect on the lateral efficiency. Impact of traffic intensity on the lateral efficiency might be explained by frequent hold-on patterns and flight trajectory extensions due to vectoring in high traffic conditions. Further investigation is needed to explain weather and vertical/lateral efficiency correlations, the conclusions might be country-specific.", "doi": "10.1016/j.jairtraman.2022.102327", "pmid": "36408128", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0969-6997(22)00146-6"}, {"db": "pmc", "key": "PMC9647021"}], "notes": [], "created": "2022-11-22T10:03:00.151Z", "modified": "2022-11-22T10:03:11.662Z"}, {"entity": "publication", "iuid": "c0d8bacc5149404fb602a317c0f3e022", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c0d8bacc5149404fb602a317c0f3e022.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c0d8bacc5149404fb602a317c0f3e022"}}, "title": "Structures for collaboration and networked adaptation: Emerging themes from the COVID-19 pandemic", "authors": [{"family": "Antonsen", "given": "PhD, Stian", "initials": "PS"}, {"family": "Haavik", "given": "PhD, Torgeir Kolst\u00f8", "initials": "PTK"}, {"family": "Frykmer", "given": "PhD, Tove", "initials": "PT"}, {"family": "Gj\u00f8sund", "given": "Gudveig", "initials": "G"}], "type": "journal-article", "published": "2023-02-28", "journal": {"title": "J Emerg Manag", "issn": "1543-5865", "issn-l": null, "volume": "21", "issue": "7", "pages": "71-84"}, "abstract": null, "doi": "10.5055/jem.0705", "pmid": null, "labels": {"Category: Social Science & Humanities": null, "Type: Other": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:12:23.449Z", "modified": "2023-10-04T08:17:14.166Z"}, {"entity": "publication", "iuid": "1bf2e234720541e487e3d31dd629578b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1bf2e234720541e487e3d31dd629578b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1bf2e234720541e487e3d31dd629578b"}}, "title": "Editorial: Health service management and leadership: COVID-style.", "authors": [{"family": "Dadich", "given": "Ann", "initials": "A"}, {"family": "Buttigieg", "given": "Sandra", "initials": "S"}, {"family": "Macassa", "given": "Gloria", "initials": "G"}, {"family": "West", "given": "Thomas", "initials": "T"}], "type": "editorial", "published": "2023-02-28", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "11", "pages": "1141055", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2023.1141055", "pmid": "36926174", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10011686"}], "notes": [], "created": "2023-04-21T16:13:05.921Z", "modified": "2023-04-21T16:13:05.938Z"}, {"entity": "publication", "iuid": "3af35c66db2c41009aed93edbb5d0054", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3af35c66db2c41009aed93edbb5d0054.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3af35c66db2c41009aed93edbb5d0054"}}, "title": "Worldwide Estimation of Parental Acceptance of COVID-19 Vaccine for Their Children: A Systematic Review and Meta-Analysis.", "authors": [{"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2023-02-24", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "11", "issue": "3", "issn-l": null}, "abstract": "Currently, the best method to well control the spread of COVID-19 without severe mental health problems is to reach herd immunity. Therefore, the vaccination rate of the COVID-19 vaccine is critical. Among the populations, children are the vulnerable ones to get vaccinated; therefore, it is important to assess parents' and guardians' willingness to have their children vaccinated. The present systematic review and meta-analysis synthesized evidence to estimate the parents' acceptance rate of COVID-19 vaccination toward their children. Additionally, factors explaining the acceptance rate were investigated. Four academic databases (PubMed, Scopus, Web of Science, and ProQuest) together with Google Scholar were searched, and the references of the included publications were searched as well. Using the PECO-S framework (population, exposure, comparison, outcome, and study design), observational studies of cross-sectional, cohort, or case-control studies were included. The outcome was parents' or guardians' willingness to let their children be vaccinated. The studies included in the present review were restricted to English and peer-reviewed papers published between December 2019 and July 2022. A total of 98 papers across 69 different countries with 413,590 participants were included. The mean age of the parents was 39.10 (range: 18-70) years and that of their children was 8.45 (range: 0-18) years. The pooled estimated prevalence of parental acceptance to vaccinate their children with the COVID-19 vaccine was 57% (98 studies, 95% CI: 52-62%, I2: 99.92%, \u03c42: 0.06). Moreover, data collection time was a significant factor explaining parental willingness in the multivariable meta-regression, with a 13% decrease in parental willingness by each month increase in time, explaining 11.44% of variance. Qualitative synthesis results showed that parents' COVID-19 vaccine knowledge, trust in theCOVID-19 vaccine, and facilitators in vaccination (e.g., low cost, good vaccine accessibility, and government incentive) were significant factors for higher willingness, while mental health problems (e.g., having worries and psychological distress) were significant factors for lower willingness. Given that the acceptance rate was relatively low (57%) and does not achieve the requirement of herd immunity (i.e., 70%), governments and healthcare authorities should try to elevate parents' knowledge and trust in the COVID-19 vaccine, facilitate in vaccination, and reduce their mental difficulties to improve the overall vaccination rate among children.", "doi": "10.3390/vaccines11030533", "pmid": "36992117", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10051081"}, {"db": "pii", "key": "vaccines11030533"}], "notes": [], "created": "2023-04-21T15:55:33.559Z", "modified": "2023-04-21T15:55:33.576Z"}, {"entity": "publication", "iuid": "f1eb1c6f4d1f4c57b823461a287975eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1eb1c6f4d1f4c57b823461a287975eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1eb1c6f4d1f4c57b823461a287975eb"}}, "title": "Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia.", "authors": [{"family": "Palma Medina", "given": "Laura M", "initials": "LM"}, {"family": "Baba\u010di\u0107", "given": "Haris", "initials": "H"}, {"family": "Dzidic", "given": "Majda", "initials": "M"}, {"family": "Parke", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Garcia", "given": "Marina", "initials": "M"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Unge", "given": "Christian", "initials": "C"}, {"family": "Lourda", "given": "Magda", "initials": "M"}, {"family": "Kvedaraite", "given": "Egle", "initials": "E"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Muvva", "given": "Jagadeeswara Rao", "initials": "JR"}, {"family": "Cornillet", "given": "Martin", "initials": "M"}, {"family": "Emg\u00e5rd", "given": "Johanna", "initials": "J"}, {"family": "Moll", "given": "Kirsten", "initials": "K"}, {"family": "Karolinska K. I./K. COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Flodstr\u00f6m-Tullberg", "given": "Malin", "initials": "M"}, {"family": "Brighenti", "given": "Susanna", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J"}, {"family": "Malmberg", "given": "Karl-Johan", "initials": "KJ"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Svensson", "given": "Mattias", "initials": "M"}, {"family": "Chambers", "given": "Benedict J", "initials": "BJ"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Pernemalm", "given": "Maria", "initials": "M"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2023-02-24", "journal": {"title": "Respir Res", "issn": "1465-993X", "volume": "24", "issue": "1", "pages": "62", "issn-l": "1465-9921"}, "abstract": "COVID-19 remains a major public health challenge, requiring the development of tools to improve diagnosis and inform therapeutic decisions. As dysregulated inflammation and coagulation responses have been implicated in the pathophysiology of COVID-19 and sepsis, we studied their plasma proteome profiles to delineate similarities from specific features.\n\nWe measured 276 plasma proteins involved in Inflammation, organ damage, immune response and coagulation in healthy controls, COVID-19 patients during acute and convalescence phase, and sepsis patients; the latter included (i) community-acquired pneumonia (CAP) caused by Influenza, (ii) bacterial CAP, (iii) non-pneumonia sepsis, and (iv) septic shock patients.\n\nWe identified a core response to infection consisting of 42 proteins altered in both COVID-19 and sepsis, although higher levels of cytokine storm-associated proteins were evident in sepsis. Furthermore, microbiologic etiology and clinical endotypes were linked to unique signatures. Finally, through machine learning, we identified biomarkers, such as TRIM21, PTN and CASP8, that accurately differentiated COVID-19 from CAP-sepsis with higher accuracy than standard clinical markers.\n\nThis study extends the understanding of host responses underlying sepsis and COVID-19, indicating varying disease mechanisms with unique signatures. These diagnostic and severity signatures are candidates for the development of personalized management of COVID-19 and sepsis.", "doi": "10.1186/s12931-023-02364-y", "pmid": "36829233", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12931-023-02364-y"}, {"db": "pmc", "key": "PMC9950694"}], "notes": [], "created": "2023-02-27T17:22:27.856Z", "modified": "2023-02-27T17:29:11.649Z"}, {"entity": "publication", "iuid": "845ac1efd1a14178af13474487957dbd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/845ac1efd1a14178af13474487957dbd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/845ac1efd1a14178af13474487957dbd"}}, "title": "Risk factors for impaired respiratory function post COVID-19: A prospective cohort study of nonhospitalized and hospitalized patients.", "authors": [{"family": "Bj\u00f6rsell", "given": "Tove", "initials": "T"}, {"family": "Sundh", "given": "Josefin", "initials": "J"}, {"family": "Lange", "given": "Anna", "initials": "A"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Tevell", "given": "Staffan", "initials": "S"}, {"family": "Blomberg", "given": "Anders", "initials": "A"}, {"family": "Edin", "given": "Alicia", "initials": "A"}, {"family": "Normark", "given": "Johan", "initials": "J", "orcid": "0000-0001-5831-4369", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cab4f084027e4e4b8f0e5113a499e5c6.json"}}, {"family": "Cajander", "given": "Sara", "initials": "S"}], "type": "journal article", "published": "2023-02-23", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null}, "abstract": "Severe COVID-19 increases the risk for long-term respiratory impairment, but data after mild COVID-19 are scarce. Our aims were to determine risk factors for reduced respiratory function 3-6 months after COVID-19 infection and to investigate if reduced respiratory function would relate to impairment of exercise performance and breathlessness.\n\nPatients with COVID-19 were enrolled at the University Hospitals of Ume\u00e5 and \u00d6rebro, and Karlstad Central Hospital, Sweden. Disease severity was defined as mild (nonhospitalized), moderate (hospitalized with or without oxygen treatment), and severe (intensive care). Spirometry, including diffusion capacity (DLCO ), was performed 3-6 months after hospital discharge or study enrollment (for nonhospitalized patients). Breathlessness (defined as \u22651 according to the modified Medical Research Council scale) and functional exercise capacity (1-min sit-to-stand test; 1-MSTST) were assessed.\n\nBetween April 2020 and May 2021, 337 patients were enrolled in the study. Forced vital capacity and DLCO were significantly lower in patients with severe COVID-19. Among hospitalized patients, 20% had reduced DLCO , versus 4% in nonhospitalized. Breathlessness was found in 40.6% of the participants and was associated with impaired DLCO . A pathological desaturation or heart rate response was observed in 17% of participants during the 1-MSTST. However, this response was not associated with reduced DLCO .\n\nReduced DLCO was the major respiratory impairment 3-6 months following COVID-19, with hospitalization as the most important risk factor. The lack of association between impaired DLCO and pathological physiological responses to exertion suggests that these physiological responses are not primarily related to decreased lung function.", "doi": "10.1111/joim.13614", "pmid": "36815689", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-02-27T17:24:16.046Z", "modified": "2023-02-27T17:24:27.993Z"}, {"entity": "publication", "iuid": "b9313c5ab4074c5291baf361990a877c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9313c5ab4074c5291baf361990a877c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9313c5ab4074c5291baf361990a877c"}}, "title": "Inhaled ciclesonide in adults hospitalised with COVID-19: a randomised controlled open-label trial (HALT COVID-19).", "authors": [{"family": "Brodin", "given": "Daniel", "initials": "D"}, {"family": "Tornhammar", "given": "Per", "initials": "P", "orcid": "0000-0003-1043-1894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30bc2420c4c54a65986ab73c60d45def.json"}}, {"family": "Ueda", "given": "Peter", "initials": "P"}, {"family": "Krifors", "given": "Anders", "initials": "A"}, {"family": "Westerlund", "given": "Eli", "initials": "E", "orcid": "0000-0001-5453-1796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06c564d3974f4436bc6c93b94b99eff6.json"}}, {"family": "Athlin", "given": "Simon", "initials": "S"}, {"family": "Wojt", "given": "Sandra", "initials": "S"}, {"family": "Elvstam", "given": "Olof", "initials": "O"}, {"family": "Neumann", "given": "Anca", "initials": "A"}, {"family": "Elshani", "given": "Arsim", "initials": "A"}, {"family": "Giesecke", "given": "Julia", "initials": "J"}, {"family": "Edvardsson-K\u00e4llkvist", "given": "Jens", "initials": "J"}, {"family": "Bunpuckdee", "given": "Sayam", "initials": "S"}, {"family": "Unge", "given": "Christian", "initials": "C"}, {"family": "Larsson", "given": "Martin", "initials": "M"}, {"family": "Johansson", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Ljungberg", "given": "Johan", "initials": "J"}, {"family": "Lindell", "given": "Jonas", "initials": "J"}, {"family": "Hansson", "given": "Johan", "initials": "J"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Andersson", "given": "Daniel Peter", "initials": "DP", "orcid": "0000-0003-4655-4837", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e35f15e626c045c191bd14a522a85c0e.json"}}], "type": "randomized controlled trial", "published": "2023-02-22", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "13", "issue": "2", "pages": "e064374", "issn-l": "2044-6055"}, "abstract": "To assess the efficacy of inhaled ciclesonide in reducing the duration of oxygen therapy (an indicator of time to clinical improvement) among adults hospitalised with COVID-19.\n\nMulticentre, randomised, controlled, open-label trial.\n\n9 hospitals (3 academic hospitals and 6 non-academic hospitals) in Sweden between 1 June 2020 and 17 May 2021.\n\nAdults hospitalised with COVID-19 and receiving oxygen therapy.\n\nInhaled ciclesonide 320 \u00b5g two times a day for 14 days versus standard care.\n\nPrimary outcome was duration of oxygen therapy, an indicator of time to clinical improvement. Key secondary outcome was a composite of invasive mechanical ventilation/death.\n\nData from 98 participants were analysed (48 receiving ciclesonide and 50 receiving standard care; median (IQR) age, 59.5 (49-67) years; 67 (68%) men). Median (IQR) duration of oxygen therapy was 5.5 (3-9) days in the ciclesonide group and 4 (2-7) days in the standard care group (HR for termination of oxygen therapy 0.73 (95% CI 0.47 to 1.11), with the upper 95% CI being compatible with a 10% relative reduction in oxygen therapy duration, corresponding to a <1 day absolute reduction in a post-hoc calculation). Three participants in each group died/received invasive mechanical ventilation (HR 0.90 (95% CI 0.15 to 5.32)). The trial was discontinued early due to slow enrolment.\n\nIn patients hospitalised with COVID-19 receiving oxygen therapy, this trial ruled out, with 0.95 confidence, a treatment effect of ciclesonide corresponding to more than a 1 day reduction in duration of oxygen therapy. Ciclesonide is unlikely to improve this outcome meaningfully.\n\nNCT04381364.", "doi": "10.1136/bmjopen-2022-064374", "pmid": "36813503", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC9950582"}, {"db": "pii", "key": "bmjopen-2022-064374"}, {"db": "ClinicalTrials.gov", "key": "NCT04381364"}], "notes": [], "created": "2023-02-27T17:21:44.921Z", "modified": "2023-02-27T17:21:59.005Z"}, {"entity": "publication", "iuid": "24e7b24a49204215aa186411efb8ad01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24e7b24a49204215aa186411efb8ad01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24e7b24a49204215aa186411efb8ad01"}}, "title": "Attitudes of Swedish Language Twitter Users Toward COVID-19 Vaccination: Exploratory Qualitative Study.", "authors": [{"family": "Beirakdar", "given": "Safwat", "initials": "S", "orcid": "0000-0002-3015-5754", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f74cf5c04b1492790e518ae4b161779.json"}}, {"family": "Klingborg", "given": "Leon", "initials": "L", "orcid": "0000-0002-1662-7890", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/17924357598546489de2acc485c0643f.json"}}, {"family": "Herzig van Wees", "given": "Sibylle", "initials": "S", "orcid": "0000-0002-5270-1170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e2480c5cb4545a0a707cf74fb9a6322.json"}}], "type": "journal article", "published": "2023-02-22", "journal": {"title": "JMIR Infodemiology", "issn": "2564-1891", "volume": "3", "pages": "e42357", "issn-l": null}, "abstract": "Social media have played an important role in shaping COVID-19 vaccine choices during the pandemic. Understanding people's attitudes toward the vaccine as expressed on social media can help address the concerns of vaccine-hesitant individuals.\n\nThe aim of this study was to understand the attitudes of Swedish-speaking Twitter users toward COVID-19 vaccines.\n\nThis was an exploratory qualitative study that used a social media-listening approach. Between January and March 2022, a total of 2877 publicly available tweets in Swedish were systematically extracted from Twitter. A deductive thematic analysis was conducted using the World Health Organization's 3C model (confidence, complacency, and convenience).\n\nConfidence in the safety and effectiveness of the COVID-19 vaccine appeared to be a major concern expressed on Twitter. Unclear governmental strategies in managing the pandemic in Sweden and the belief in conspiracy theories have further influenced negative attitudes toward vaccines. Complacency-the perceived risk of COVID-19 was low and booster vaccination was unnecessary; many expressed trust in natural immunity. Convenience-in terms of accessing the right information and the vaccine-highlighted a knowledge gap about the benefits and necessity of the vaccine, as well as complaints about the quality of vaccination services.\n\nSwedish-speaking Twitter users in this study had negative attitudes toward COVID-19 vaccines, particularly booster vaccines. We identified attitudes toward vaccines and misinformation, indicating that social media monitoring can help policy makers respond by developing proactive health communication interventions.", "doi": "10.2196/42357", "pmid": "37012999", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9996415"}, {"db": "pii", "key": "v3i1e42357"}], "notes": [], "created": "2023-04-19T16:41:04.539Z", "modified": "2023-04-20T17:34:37.417Z"}, {"entity": "publication", "iuid": "db6afbf613f94ad1a97b041a9a9acdde", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db6afbf613f94ad1a97b041a9a9acdde.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db6afbf613f94ad1a97b041a9a9acdde"}}, "title": "Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity.", "authors": [{"family": "Yoshiji", "given": "Satoshi", "initials": "S", "orcid": "0000-0001-8863-2413", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b4aff6c38b244e98d3ba65db57c1637.json"}}, {"family": "Butler-Laporte", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-5388-0396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/529dc69151d3463e8480b975d70fa759.json"}}, {"family": "Lu", "given": "Tianyuan", "initials": "T", "orcid": "0000-0002-5664-5698", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e379dceef0244aa7b76f24294f72c537.json"}}, {"family": "Willett", "given": "Julian Daniel Sunday", "initials": "JDS"}, {"family": "Su", "given": "Chen-Yang", "initials": "CY", "orcid": "0000-0001-6071-4660", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cdedd44e2dbd4723893f827517a64732.json"}}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T", "orcid": "0000-0001-9510-5646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd273e50091d44c3b3e8d1473ce89b0a.json"}}, {"family": "Morrison", "given": "David R", "initials": "DR", "orcid": "0000-0001-8380-3615", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6099e7b5999e486eb486bac1f455fdc1.json"}}, {"family": "Chen", "given": "Yiheng", "initials": "Y"}, {"family": "Liang", "given": "Kevin", "initials": "K"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Ilboudo", "given": "Yann", "initials": "Y"}, {"family": "Afrasiabi", "given": "Zaman", "initials": "Z", "orcid": "0000-0003-4395-5168", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/794e813ab12a49b8b92067ae83a0b8bb.json"}}, {"family": "Lan", "given": "Shanshan", "initials": "S"}, {"family": "Duggan", "given": "Naomi", "initials": "N"}, {"family": "DeLuca", "given": "Chantal", "initials": "C"}, {"family": "Vaezi", "given": "Mitra", "initials": "M"}, {"family": "Tselios", "given": "Chris", "initials": "C"}, {"family": "Xue", "given": "Xiaoqing", "initials": "X"}, {"family": "Bouab", "given": "Meriem", "initials": "M"}, {"family": "Shi", "given": "Fangyi", "initials": "F"}, {"family": "Laurent", "given": "Laetitia", "initials": "L"}, {"family": "M\u00fcnter", "given": "Hans Markus", "initials": "HM", "orcid": "0000-0002-3165-2840", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f3f86c18235456688c86013f19703b4.json"}}, {"family": "Afilalo", "given": "Marc", "initials": "M"}, {"family": "Afilalo", "given": "Jonathan", "initials": "J"}, {"family": "Mooser", "given": "Vincent", "initials": "V", "orcid": "0000-0002-8632-0448", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7af40c95aeaf4dd7ab639b31f773b89a.json"}}, {"family": "Timpson", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0002-7141-9189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90b26df69dcd46bd9f6e4eebbf46a36f.json"}}, {"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "Zhou", "given": "Sirui", "initials": "S"}, {"family": "Forgetta", "given": "Vincenzo", "initials": "V"}, {"family": "Farjoun", "given": "Yossi", "initials": "Y"}, {"family": "Richards", "given": "J Brent", "initials": "JB", "orcid": "0000-0002-3746-9086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8994152547ee4765b1653b834c52a21a.json"}}], "type": "journal article", "published": "2023-02-20", "journal": {"title": "Nat Metab", "issn": "2522-5812", "pages": "1-17", "issn-l": null}, "abstract": "Obesity is a major risk factor for Coronavirus disease (COVID-19) severity; however, the mechanisms underlying this relationship are not fully understood. As obesity influences the plasma proteome, we sought to identify circulating proteins mediating the effects of obesity on COVID-19 severity in humans. Here, we screened 4,907 plasma proteins to identify proteins influenced by body mass index using Mendelian randomization. This yielded 1,216 proteins, whose effect on COVID-19 severity was assessed, again using Mendelian randomization. We found that an s.d. increase in nephronectin (NPNT) was associated with increased odds of critically ill COVID-19 (OR = 1.71, P = 1.63 \u00d7 10-10). The effect was driven by an NPNT splice isoform. Mediation analyses supported NPNT as a mediator. In single-cell RNA-sequencing, NPNT was expressed in alveolar cells and fibroblasts of the lung in individuals who died of COVID-19. Finally, decreasing body fat mass and increasing fat-free mass were found to lower NPNT levels. These findings provide actionable insights into how obesity influences COVID-19 severity.", "doi": "10.1038/s42255-023-00742-w", "pmid": "36805566", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC9940690"}, {"db": "pii", "key": "10.1038/s42255-023-00742-w"}], "notes": [], "created": "2023-02-27T17:28:10.291Z", "modified": "2023-02-27T17:28:10.490Z"}, {"entity": "publication", "iuid": "85d25302102c460dae7b0c13bb3014db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/85d25302102c460dae7b0c13bb3014db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/85d25302102c460dae7b0c13bb3014db"}}, "title": "New Presentation of CD27 Deficiency; Coronary Ectasia and COVID-19.", "authors": [{"family": "Golchehre", "given": "Zahra", "initials": "Z"}, {"family": "Sharafian", "given": "Samin", "initials": "S"}, {"family": "Momtazmanesh", "given": "Nader", "initials": "N"}, {"family": "Chavoshzadeh", "given": "Zahra", "initials": "Z"}, {"family": "Karimi", "given": "Abdollah", "initials": "A"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Kazemi Aghdam", "given": "Maryam", "initials": "M"}, {"family": "Vahidshahi", "given": "Koroush", "initials": "K"}, {"family": "Hashemimoghaddam", "given": "Seyedehatefeh", "initials": "S"}, {"family": "Kosari", "given": "Farid", "initials": "F"}, {"family": "Khafafpour", "given": "Zahra", "initials": "Z"}, {"family": "Shamsian", "given": "Bibi Shahin", "initials": "BS"}, {"family": "Keramatipour", "given": "Mohammad", "initials": "M"}], "type": "journal article", "published": "2023-02-20", "journal": {"title": "Iran J Allergy Asthma Immunol", "issn": "1735-5249", "volume": "22", "issue": "1", "pages": "110-118", "issn-l": null}, "abstract": "CD27 is a costimulatory receptor involved in the maturation of the innate and adaptive immunity. CD27, through interaction with CD70, plays a role in the control of Epstein-Barr virus (EBV) infection. CD27 deficiency leads to an immune dysregulation disease characterized by EBV susceptibility. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might put patients with primary immunodeficiency at risk for adverse outcomes. Chromogenic in situ hybridization (CISH) study was performed to detect EBV in the lymphoma tissue. Genetic analysis of the patient was done with Whole Exome Sequencing and detected variant was confirmed with PCR-Sanger sequencing. Here we report a 20-month-old boy with CD27 deficiency who developed lymphoma and coronary artery ectasia and had been infected with SARS-CoV-2. Clinical and laboratory findings were incompatible with atypical Kawasaki syndrome or multisystem inflammatory syndrome in children (MIS-C). As CD27 deficiency is a rare immune defect, publishing clinical data about the identified patient(s) can shed light on our knowledge about the related phenotype and the spectrum of clinical manifestations associated with CD27 deficiency. Thus, our findings expanded the spectrum of manifestations beyond EBV infection, highlighting this unusual cardiac sequela that could be related to EBV infection, lymphoma, or an underlying disease.", "doi": "10.18502/ijaai.v22i1.12013", "pmid": "37002625", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-04-20T17:41:34.380Z", "modified": "2023-04-20T17:41:34.413Z"}, {"entity": "publication", "iuid": "a2e01bfc1523496fb967631f70974504", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2e01bfc1523496fb967631f70974504.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2e01bfc1523496fb967631f70974504"}}, "title": "Lipid Nanoparticles Deliver the Therapeutic VEGFA mRNA In Vitro and In Vivo and Transform Extracellular Vesicles for Their Functional Extensions.", "authors": [{"family": "Nawaz", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-0792-8296", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/371c4ed4410a443299531a5137b3f51d.json"}}, {"family": "Heydarkhan-Hagvall", "given": "Sepideh", "initials": "S"}, {"family": "Tangruksa", "given": "Benyapa", "initials": "B"}, {"family": "Gonz\u00e1lez-King Garibotti", "given": "Hern\u00e1n", "initials": "H"}, {"family": "Jing", "given": "Yujia", "initials": "Y"}, {"family": "Maugeri", "given": "Marco", "initials": "M"}, {"family": "Kohl", "given": "Franziska", "initials": "F"}, {"family": "Hultin", "given": "Leif", "initials": "L"}, {"family": "Reyahi", "given": "Azadeh", "initials": "A"}, {"family": "Camponeschi", "given": "Alessandro", "initials": "A"}, {"family": "Kull", "given": "Bengt", "initials": "B"}, {"family": "Christoffersson", "given": "Jonas", "initials": "J"}, {"family": "Grimsholm", "given": "Ola", "initials": "O", "orcid": "0000-0003-2064-2556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35635778f5ff488a9e74710bea12541e.json"}}, {"family": "Jennbacken", "given": "Karin", "initials": "K"}, {"family": "Sundqvist", "given": "Martina", "initials": "M", "orcid": "0000-0002-0859-0792", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a430c7ad6be440c78357a4c7f3e59a95.json"}}, {"family": "Wiseman", "given": "John", "initials": "J"}, {"family": "Bidar", "given": "Abdel Wahad", "initials": "AW"}, {"family": "Lindfors", "given": "Lennart", "initials": "L"}, {"family": "Synnergren", "given": "Jane", "initials": "J"}, {"family": "Valadi", "given": "Hadi", "initials": "H", "orcid": "0000-0003-3482-2451", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebbd5ef128eb464b969e08d93c050246.json"}}], "type": "journal article", "published": "2023-02-19", "journal": {"title": "Adv. Sci.", "issn": "2198-3844", "pages": "e2206187", "issn-l": null}, "abstract": "Lipid nanoparticles (LNPs) are currently used to transport functional mRNAs, such as COVID-19 mRNA vaccines. The delivery of angiogenic molecules, such as therapeutic VEGF-A mRNA, to ischemic tissues for producing new blood vessels is an emerging strategy for the treatment of cardiovascular diseases. Here, the authors deliver VEGF-A mRNA via LNPs and study stoichiometric quantification of their uptake kinetics and how the transport of exogenous LNP-mRNAs between cells is functionally extended by cells' own vehicles called extracellular vesicles (EVs). The results show that cellular uptake of LNPs and their mRNA molecules occurs quickly, and that the translation of exogenously delivered mRNA begins immediately. Following the VEGF-A mRNA delivery to cells via LNPs, a fraction of internalized VEGF-A mRNA is secreted via EVs. The overexpressed VEGF-A mRNA is detected in EVs secreted from three different cell types. Additionally, RNA-Seq analysis reveals that as cells' response to LNP-VEGF-A mRNA treatment, several overexpressed proangiogenic transcripts are packaged into EVs. EVs are further deployed to deliver VEGF-A mRNA in vitro and in vivo. Upon equal amount of VEGF-A mRNA delivery via three EV types or LNPs in vitro, EVs from cardiac progenitor cells are the most efficient in promoting angiogenesis per amount of VEGF-A protein produced. Intravenous administration of luciferase mRNA shows that EVs could distribute translatable mRNA to different organs with the highest amounts of luciferase detected in the liver. Direct injections of VEGF-A mRNA (via EVs or LNPs) into mice heart result in locally produced VEGF-A protein without spillover to liver and circulation. In addition, EVs from cardiac progenitor cells cause minimal production of inflammatory cytokines in cardiac tissue compared with all other treatment types. Collectively, the data demonstrate that LNPs transform EVs as functional extensions to distribute therapeutic mRNA between cells, where EVs deliver this mRNA differently than LNPs.", "doi": "10.1002/advs.202206187", "pmid": "36806740", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-02-27T17:27:20.630Z", "modified": "2023-02-27T17:27:20.759Z"}, {"entity": "publication", "iuid": "ac1abbf0ce2948ee94e770dabb6574fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac1abbf0ce2948ee94e770dabb6574fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac1abbf0ce2948ee94e770dabb6574fd"}}, "title": "Differential regulation of mRNA stability modulates transcriptional memory and facilitates environmental adaptation.", "authors": [{"family": "Li", "given": "Bingnan", "initials": "B", "orcid": "0000-0001-8143-4035", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53b7a6990ba146c0a6417e5301261b5a.json"}}, {"family": "Zeis", "given": "Patrice", "initials": "P", "orcid": "0000-0001-7615-2201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df9459746cb14785ae7b8dcc8f90a485.json"}}, {"family": "Zhang", "given": "Yujie", "initials": "Y"}, {"family": "Alekseenko", "given": "Alisa", "initials": "A"}, {"family": "F\u00fcrst", "given": "Eliska", "initials": "E", "orcid": "0000-0001-7101-5347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/239337d0862a43e6b8d202b8614db1bc.json"}}, {"family": "Sanchez", "given": "Yerma Pareja", "initials": "YP"}, {"family": "Lin", "given": "Gen", "initials": "G", "orcid": "0000-0001-9969-8418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3e8e9a47be743a9b14048fc342b671b.json"}}, {"family": "Tekkedil", "given": "Manu M", "initials": "MM"}, {"family": "Piazza", "given": "Ilaria", "initials": "I"}, {"family": "Steinmetz", "given": "Lars M", "initials": "LM"}, {"family": "Pelechano", "given": "Vicent", "initials": "V", "orcid": "0000-0002-9415-788X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce53b4c829e547399014c2d8042dde35.json"}}], "type": "journal article", "published": "2023-02-17", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "910", "issn-l": "2041-1723"}, "abstract": "Transcriptional memory, by which cells respond faster to repeated stimuli, is key for cellular adaptation and organism survival. Chromatin organization has been shown to play a role in the faster response of primed cells. However, the contribution of post-transcriptional regulation is not yet explored. Here we perform a genome-wide screen to identify novel factors modulating transcriptional memory in S. cerevisiae in response to galactose. We find that depletion of the nuclear RNA exosome increases GAL1 expression in primed cells. Our work shows that gene-specific differences in intrinsic nuclear surveillance factor association can enhance both gene induction and repression in primed cells. Finally, we show that primed cells present altered levels of RNA degradation machinery and that both nuclear and cytoplasmic mRNA decay modulate transcriptional memory. Our results demonstrate that mRNA post-transcriptional regulation, and not only transcription regulation, should be considered when investigating gene expression memory.", "doi": "10.1038/s41467-023-36586-x", "pmid": "36801853", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC9936472"}, {"db": "pii", "key": "10.1038/s41467-023-36586-x"}], "notes": [], "created": "2023-02-27T17:25:01.083Z", "modified": "2023-06-19T15:33:33.755Z"}, {"entity": "publication", "iuid": "86d2b7403ad64b9f8ca7e607937227c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86d2b7403ad64b9f8ca7e607937227c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86d2b7403ad64b9f8ca7e607937227c0"}}, "title": "Increasing serum iron levels and their role in the risk of infectious diseases: a Mendelian randomization approach.", "authors": [{"family": "Butler-Laporte", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-5388-0396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/529dc69151d3463e8480b975d70fa759.json"}}, {"family": "Farjoun", "given": "Yossi", "initials": "Y"}, {"family": "Chen", "given": "Yiheng", "initials": "Y"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Liang", "given": "Kevin Y H", "initials": "KYH"}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T", "orcid": "0000-0001-9510-5646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd273e50091d44c3b3e8d1473ce89b0a.json"}}, {"family": "Su", "given": "Chen-Yang", "initials": "CY"}, {"family": "Yoshiji", "given": "Satoshi", "initials": "S"}, {"family": "Forgetta", "given": "Vincenzo", "initials": "V", "orcid": "0000-0002-6061-4720", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/347fc19ca94d4a498fc5b04634046425.json"}}, {"family": "Richards", "given": "J Brent", "initials": "JB", "orcid": "0000-0002-3746-9086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8994152547ee4765b1653b834c52a21a.json"}}], "type": "journal article", "published": "2023-02-11", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "issn-l": "0300-5771"}, "abstract": "Increased iron stores have been associated with elevated risks of different infectious diseases, suggesting that iron supplementation may increase the risk of infections. However, these associations may be biased by confounding or reverse causation. This is important, since up to 19% of the population takes iron supplementation. We used Mendelian randomization (MR) to bypass these biases and estimate the causal effect of iron on infections.\n\nAs instrumental variables, we used genetic variants associated with iron biomarkers in two genome-wide association studies (GWASs) of European ancestry participants. For outcomes, we used GWAS results from the UK Biobank, FinnGen, the COVID-19 Host Genetics Initiative or 23andMe, for seven infection phenotypes: 'any infections', combined, COVID-19 hospitalization, candidiasis, pneumonia, sepsis, skin and soft tissue infection (SSTI) and urinary tract infection (UTI).\n\nMost of our analyses showed increasing iron (measured by its biomarkers) was associated with only modest changes in the odds of infectious outcomes, with all 95% odds ratios confidence intervals within the 0.88 to 1.26 range. However, for the three predominantly bacterial infections (sepsis, SSTI, UTI), at least one analysis showed a nominally elevated risk with increased iron stores (P <0.05).\n\nUsing MR, we did not observe an increase in risk of most infectious diseases with increases in iron stores. However for bacterial infections, higher iron stores may increase odds of infections. Hence, using genetic variation in iron pathways as a proxy for iron supplementation, iron supplements are likely safe on a population level, but we should continue the current practice of conservative iron supplementation during bacterial infections or in those at high risk of developing them.", "doi": "10.1093/ije/dyad010", "pmid": "36773317", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "7034613"}], "notes": [], "created": "2023-02-13T17:59:17.506Z", "modified": "2023-02-13T17:59:27.451Z"}, {"entity": "publication", "iuid": "82fdb9dd967b4b5b9838d495f2cb101b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82fdb9dd967b4b5b9838d495f2cb101b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82fdb9dd967b4b5b9838d495f2cb101b"}}, "title": "Antibiotic use during coronavirus disease 2019 intensive care unit shape multidrug resistance bacteriuria: A Swedish longitudinal prospective study.", "authors": [{"family": "Karlsson", "given": "Philip A", "initials": "PA"}, {"family": "P\u00e4rssinen", "given": "Julia", "initials": "J"}, {"family": "Danielsson", "given": "Erik A", "initials": "EA"}, {"family": "Fatsis-Kavalopoulos", "given": "Nikos", "initials": "N"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}, {"family": "Wang", "given": "Helen", "initials": "H"}], "type": "journal article", "published": "2023-02-07", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "10", "pages": "1087446", "issn-l": null}, "abstract": "High frequency of antimicrobial prescription and the nature of prolonged illness in COVID-19 increases risk for complicated bacteriuria and antibiotic resistance. We investigated risk factors for bacteriuria in the ICU and the correlation between antibiotic treatment and persistent bacteria.\n\nWe conducted a prospective longitudinal study with urine from indwelling catheters of 101 ICU patients from Uppsala University Hospital, Sweden. Samples were screened and isolates confirmed with MALDI-TOF and whole genome sequencing. Isolates were analyzed for AMR using broth microdilution. Clinical data were assessed for correlation with bacteriuria.\n\nLength of stay linearly correlated with bacteriuria (R2 = 0.99, p \u2264 0.0001). 90% of patients received antibiotics, primarily the beta-lactams (76%) cefotaxime, piperacillin-tazobactam, and meropenem. We found high prevalence of Enterococcus (42%) being associated with increased cefotaxime prescription. Antibiotic-susceptible E. coli were found to cause bacteriuria despite concurrent antibiotic treatment when found in co-culture with Enterococcus.\n\nLonger stays in ICUs increase the risk for bacteriuria in a predictable manner. Likely, high use of cefotaxime drives Enterococcus prevalence, which in turn permit co-colonizing Gram-negative bacteria. Our results suggest biofilms in urinary catheters as a reservoir of pathogenic bacteria with the potential to develop and disseminate AMR.", "doi": "10.3389/fmed.2023.1087446", "pmid": "36824610", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC9941185"}], "notes": [], "created": "2023-02-27T17:27:48.653Z", "modified": "2023-02-27T17:27:48.666Z"}, {"entity": "publication", "iuid": "a4366a6d02d248b797694c9f9ecf6fab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a4366a6d02d248b797694c9f9ecf6fab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a4366a6d02d248b797694c9f9ecf6fab"}}, "title": "High prevalence of persistent symptoms and reduced health-related quality of life 6 months after COVID-19.", "authors": [{"family": "Ahmad", "given": "Irma", "initials": "I"}, {"family": "Edin", "given": "Alicia", "initials": "A"}, {"family": "Granvik", "given": "Christoffer", "initials": "C"}, {"family": "Kumm Persson", "given": "Lowa", "initials": "L"}, {"family": "Tevell", "given": "Staffan", "initials": "S"}, {"family": "M\u00e5nsson", "given": "Emeli", "initials": "E"}, {"family": "Magnuson", "given": "Anders", "initials": "A"}, {"family": "Marklund", "given": "Ingela", "initials": "I"}, {"family": "Persson", "given": "Ida-Lisa", "initials": "IL"}, {"family": "Kauppi", "given": "Anna", "initials": "A"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Sundh", "given": "Josefin", "initials": "J"}, {"family": "Lange", "given": "Anna", "initials": "A"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "Normark", "given": "Johan", "initials": "J"}], "type": "multicenter study", "published": "2023-02-02", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "11", "pages": "1104267", "issn-l": "2296-2565"}, "abstract": "The long-term sequelae after COVID-19 constitute a challenge to public health and increased knowledge is needed. We investigated the prevalence of self-reported persistent symptoms and reduced health-related quality of life (HRQoL) in relation to functional exercise capacity, 6 months after infection, and explored risk factors for COVID-19 sequalae.\n\nThis was a prospective, multicenter, cohort study including 434 patients. At 6 months, physical exercise capacity was assessed by a 1-minute sit-to-stand test (1MSTST) and persistent symptoms were reported and HRQoL was evaluated through the EuroQol 5-level 5-dimension (EQ-5D-5L) questionnaire. Patients with both persistent symptoms and reduced HRQoL were classified into a new definition of post-acute COVID syndrome, PACS+. Risk factors for developing persistent symptoms, reduced HRQoL and PACS+ were identified by multivariable Poisson regression.\n\nPersistent symptoms were experienced by 79% of hospitalized, and 59% of non-hospitalized patients at 6 months. Hospitalized patients had a higher prevalence of self-assessed reduced overall health (28 vs. 12%) and PACS+ (31 vs. 11%). PACS+ was associated with reduced exercise capacity but not with abnormal pulse/desaturation during 1MSTST. Hospitalization was the most important independent risk factor for developing persistent symptoms, reduced overall health and PACS+.\n\nPersistent symptoms and reduced HRQoL are common among COVID-19 survivors, but abnormal pulse and peripheral saturation during exercise could not distinguish patients with PACS+. Patients with severe infection requiring hospitalization were more likely to develop PACS+, hence these patients should be prioritized for clinical follow-up after COVID-19.", "doi": "10.3389/fpubh.2023.1104267", "pmid": "36817925", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC9932930"}], "notes": [], "created": "2023-02-27T17:23:53.661Z", "modified": "2023-02-27T17:24:00.330Z"}, {"entity": "publication", "iuid": "01f72b147d9c4d46b6734b4cfb0424d3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01f72b147d9c4d46b6734b4cfb0424d3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01f72b147d9c4d46b6734b4cfb0424d3"}}, "title": "Mental health indicators in Sweden over a 12-month period during the COVID-19 pandemic - Baseline data of the Omtanke2020 Study.", "authors": [{"family": "Lovik", "given": "Anik\u00f3", "initials": "A"}, {"family": "Gonz\u00e1lez-Hij\u00f3n", "given": "Juan", "initials": "J"}, {"family": "K\u00e4hler", "given": "Anna K", "initials": "AK"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Frans", "given": "Emma M", "initials": "EM"}, {"family": "Magnusson", "given": "Patrik K E", "initials": "PKE"}, {"family": "Pedersen", "given": "Nancy L", "initials": "NL"}, {"family": "Hall", "given": "Per", "initials": "P"}, {"family": "Czene", "given": "Kamila", "initials": "K"}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF"}, {"family": "Fang", "given": "Fang", "initials": "F"}], "type": "journal article", "published": "2023-02-01", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "volume": "322", "pages": "108-117", "issn-l": null}, "abstract": "The ongoing COVID-19 pandemic has had an unprecedented impact on the lives of people globally and is expected to have profound effects on mental health. Here we aim to describe the mental health burden experienced in Sweden using baseline data of the Omtanke2020 Study.\n\nWe analysed self-reported, cross-sectional baseline data collected over a 12-month period (June 9, 2020-June 8, 2021) from the Omtanke2020 Study including 27,950 adults in Sweden. Participants were volunteers or actively recruited through existing cohorts and, after providing informed consent, responded to online questionnaires on socio-demographics, mental and physical health, as well as COVID-19 infection and impact. Poisson regression was fitted to assess the relative risk of demonstrating high level symptoms of depression, anxiety, and COVID-19 related distress.\n\nThe proportion of persons with high level of symptoms was 15.6 %, 9.5 % and 24.5 % for depression, anxiety, and COVID-19 specific post-traumatic stress disorder (PTSD), respectively. Overall, 43.4 % of the participants had significant, clinically relevant symptoms for at least one of the three mental health outcomes and 7.3 % had significant symptoms for all three outcomes. We also observed differences in the prevalence of these outcomes across strata of sex, age, recruitment type, COVID-19 status, region, and seasonality.\n\nWhile the proportion of persons with high mental health burden remains higher than the ones reported in pre-pandemic publications, our estimates are lower than previously reported levels of depression, anxiety, and PTSD during the pandemic in Sweden and elsewhere.", "doi": "10.1016/j.jad.2022.11.004", "pmid": "36379324", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Preprint": null}, "xrefs": [{"db": "pmc", "key": "PMC9657895"}, {"db": "pii", "key": "S0165-0327(22)01252-6"}], "notes": [], "created": "2022-11-25T07:24:27.748Z", "modified": "2023-02-13T18:39:15.011Z"}, {"entity": "publication", "iuid": "5fc7d1a35d05441280c6096db20c361d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5fc7d1a35d05441280c6096db20c361d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5fc7d1a35d05441280c6096db20c361d"}}, "title": "Clinical outcomes of myocarditis after SARS-CoV-2 mRNA vaccination in four Nordic countries: population based cohort study.", "authors": [{"family": "Husby", "given": "Anders", "initials": "A", "orcid": "0000-0002-7634-8455", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b55ca3663d44e5b9a3b3beec78d5f2f.json"}}, {"family": "Gulseth", "given": "Hanne L\u00f8vdal", "initials": "HL"}, {"family": "Hovi", "given": "Petteri", "initials": "P"}, {"family": "Hansen", "given": "J\u00f8rgen Vinsl\u00f8v", "initials": "JV"}, {"family": "Pihlstr\u00f6m", "given": "Nicklas", "initials": "N"}, {"family": "Gunnes", "given": "Nina", "initials": "N"}, {"family": "H\u00e4rk\u00e4nen", "given": "Tommi", "initials": "T", "orcid": "0000-0002-4577-1808", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d721ae724cf2493ebb2b7f7ee71c7623.json"}}, {"family": "Dahl", "given": "Jesper", "initials": "J"}, {"family": "Karlstad", "given": "\u00d8ystein", "initials": "\u00d8"}, {"family": "Heli\u00f6", "given": "Tiina", "initials": "T"}, {"family": "K\u00f8ber", "given": "Lars", "initials": "L"}, {"family": "Ljung", "given": "Rickard", "initials": "R", "orcid": "0000-0002-0654-4530", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ba40c2b98b1442192811ba44ffbf967.json"}}, {"family": "Hviid", "given": "Anders", "initials": "A", "orcid": "0000-0002-7509-9127", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de7b6744ea454106afe080326be26390.json"}}], "type": "journal article", "published": "2023-02-01", "journal": {"title": "BMJ Med", "issn": "2754-0413", "volume": "2", "issue": "1", "pages": "e000373", "issn-l": null}, "abstract": "To investigate the clinical outcomes of myocarditis associated with mRNA vaccines against the SARS-CoV-2 virus compared with other types of myocarditis.\n\nPopulation based cohort study.\n\nNationwide register data from four Nordic countries (Denmark, Finland, Norway, and Sweden), from 1 January 2018 to the latest date of follow-up in 2022.\n\nThe Nordic myocarditis cohort; 7292 individuals aged \u226512 years who had an incident diagnosis of myocarditis as a main or secondary diagnosis, in a population of 23 million individuals in Denmark, Finland, Norway, and Sweden.\n\nHeart failure, or death from any cause within 90 days of admission to hospital for new onset myocarditis, and hospital readmission within 90 days of discharge to hospital for new onset myocarditis. Clinical outcomes of myocarditis associated with SARS-CoV-2 mRNA vaccination, covid-19 disease, and conventional myocarditis were compared.\n\nIn 2018-22, 7292 patients were admitted to hospital with new onset myocarditis, with 530 (7.3%) categorised as having myocarditis associated with SARS-CoV-2 mRNA vaccination, 109 (1.5%) with myocarditis associated with covid-19 disease, and 6653 (91.2%) with conventional myocarditis. At the 90 day follow-up, 62, nine, and 988 patients had been readmitted to hospital in each group (vaccination, covid-19, and conventional myocarditis groups, respectively), corresponding to a relative risk of readmission of 0.79 (95% confidence interval 0.62 to 1.00) and 0.55 (0.30 to 1.04) for the vaccination type and covid-19 type myocarditis groups, respectively, compared with the conventional myocarditis group. At the 90 day follow-up, 27, 18, and 616 patients had a diagnosis of heart failure or died in the vaccination type, covid-19 type, and conventional myocarditis groups, respectively. The relative risk of heart failure within 90 days was 0.56 (95% confidence interval 0.37 to 0.85) and 1.48 (0.86 to 2.54) for myocarditis associated with vaccination and covid-19 disease, respectively, compared with conventional myocarditis; the relative risk of death was 0.48 (0.21 to 1.09) and 2.35 (1.06 to 5.19), respectively. Among patients aged 12-39 years with no predisposing comorbidities, the relative risk of heart failure or death was markedly higher for myocarditis associated with covid-19 disease than for myocarditis associated with vaccination (relative risk 5.78, 1.84 to 18.20).\n\nCompared with myocarditis associated with covid-19 disease and conventional myocarditis, myocarditis after vaccination with SARS-CoV-2 mRNA vaccines was associated with better clinical outcomes within 90 days of admission to hospital.", "doi": "10.1136/bmjmed-2022-000373", "pmid": "36936260", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC9978676"}, {"db": "pii", "key": "bmjmed-2022-000373"}], "notes": [], "created": "2023-04-21T16:10:46.840Z", "modified": "2023-04-21T16:10:46.998Z"}, {"entity": "publication", "iuid": "b504cb171e774762b6d6e809b24fa3da", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b504cb171e774762b6d6e809b24fa3da.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b504cb171e774762b6d6e809b24fa3da"}}, "title": "ThermalProGAN: A sequence-based thermally stable protein generator trained using unpaired data.", "authors": [{"family": "Huang", "given": "Hui-Ling", "initials": "HL"}, {"family": "Weng", "given": "Chong-Heng", "initials": "CH"}, {"family": "Nordling", "given": "Torbj\u00f6rn E M", "initials": "TEM"}, {"family": "Liou", "given": "Yi-Fan", "initials": "YF"}], "type": "journal article", "published": "2023-02-00", "journal": {"title": "J Bioinform Comput Biol", "issn": "1757-6334", "volume": "21", "issue": "1", "pages": "2350008", "issn-l": null}, "abstract": "The synthesis of proteins with novel desired properties is challenging but sought after by the industry and academia. The dominating approach is based on trial-and-error inducing point mutations, assisted by structural information or predictive models built with paired data that are difficult to collect. This study proposes a sequence-based unpaired-sample of novel protein inventor (SUNI) to build ThermalProGAN for generating thermally stable proteins based on sequence information.\n\nThe ThermalProGAN can strongly mutate the input sequence with a median number of 32 residues. A known normal protein, 1RG0, was used to generate a thermally stable form by mutating 51 residues. After superimposing the two structures, high similarity is shown, indicating that the basic function would be conserved. Eighty four molecular dynamics simulation results of 1RG0 and the COVID-19 vaccine candidates with a total simulation time of 840[Formula: see text]ns indicate that the thermal stability increased.\n\nThis proof of concept demonstrated that transfer of a desired protein property from one set of proteins is feasible. Availability and implementation: The source code of ThermalProGAN can be freely accessed at https://github.com/markliou/ThermalProGAN/ with an MIT license. The website is https://thermalprogan.markliou.tw:433. Supplementary information: Supplementary data are available on Github.", "doi": "10.1142/S0219720023500087", "pmid": "36999645", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-21T15:50:15.045Z", "modified": "2023-04-21T15:50:15.092Z"}, {"entity": "publication", "iuid": "fdb6539aac004b4c8217f99ec69a600e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fdb6539aac004b4c8217f99ec69a600e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fdb6539aac004b4c8217f99ec69a600e"}}, "title": "The impact of COVID-19 and COVID vaccination on cardiovascular outcomes.", "authors": [{"family": "Akhtar", "given": "Zubair", "initials": "Z"}, {"family": "Trent", "given": "Mallory", "initials": "M"}, {"family": "Moa", "given": "Aye", "initials": "A"}, {"family": "Tan", "given": "Timothy C", "initials": "TC"}, {"family": "Fr\u00f6bert", "given": "Ole", "initials": "O"}, {"family": "MacIntyre", "given": "C Raina", "initials": "CR", "orcid": "0000-0002-3060-0555", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/283c1daa61384999861ce474d0678572.json"}}], "type": "journal article", "published": "2023-02-00", "journal": {"title": "Eur Heart J Suppl", "issn": "1520-765X", "volume": "25", "issue": "Suppl A", "pages": "A42-A49", "issn-l": null}, "abstract": "COVID-19 is an independent risk factor for cardiovascular disease. COVID-19 vaccination may prevent this, but in some cases, COVID-19 vaccination may cause myocarditis or pericarditis. Patients with COVID-19 may present with non-specific symptoms that have a cardiac origin. This review examines the cardiovascular complications of COVID-19 infection and the impact of COVID-19 vaccination. COVID-19 cardiovascular complications include myocardial injury, pericarditis, coagulopathy, myocardial infarction, heart failure, arrhythmias, and persistent post-acute risk of adverse cardiovascular outcomes. Diagnostic and referral pathways for non-specific symptoms, such as dyspnoea and fatigue, remain unclear. COVID-19 vaccination is cardioprotective overall but is associated with myopericarditis in young males, though at a lower rate than following SARS-CoV-2 infection. Increased awareness among primary care physicians of potential cardiovascular causes of non-specific post-COVID-19 symptoms, including in younger adults, such as fatigue, dyspnoea, and chest pain, is essential. We recommend full vaccination with scheduled booster doses, optimal management of cardiovascular risk factors, rapid treatment of COVID-19, and clear diagnostic, referral, and management pathways for patients presenting with non-specific symptoms to rule out cardiac complications.", "doi": "10.1093/eurheartjsupp/suac123", "pmid": "36937372", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10021497"}, {"db": "pii", "key": "suac123"}], "notes": [], "created": "2023-04-21T16:10:28.105Z", "modified": "2023-04-21T16:10:28.161Z"}, {"entity": "publication", "iuid": "98cff7fe9a404ee19184f6f767404caf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/98cff7fe9a404ee19184f6f767404caf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/98cff7fe9a404ee19184f6f767404caf"}}, "title": "SARS-CoV-2 spike HexaPro formulated in aluminium hydroxide and administered in an accelerated vaccination schedule partially protects Syrian Hamsters against viral challenge despite low neutralizing antibody responses.", "authors": [{"family": "Christensen", "given": "Dennis", "initials": "D"}, {"family": "Polacek", "given": "Charlotta", "initials": "C"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Hartmann", "given": "Katrine Top", "initials": "KT"}, {"family": "Jensen", "given": "Henrik Elvang", "initials": "HE"}, {"family": "Zimmermann", "given": "Julie", "initials": "J"}, {"family": "Jungersen", "given": "Gregers", "initials": "G"}, {"family": "Illigen", "given": "Kristin Engelhart", "initials": "KE"}, {"family": "Isling", "given": "Louise Krag", "initials": "LK"}, {"family": "Fernandez-Antunez", "given": "Carlota", "initials": "C"}, {"family": "Ramirez", "given": "Santseharay", "initials": "S"}, {"family": "Bukh", "given": "Jens", "initials": "J"}, {"family": "Pedersen", "given": "Gabriel Kristian", "initials": "GK"}], "type": "journal article", "published": "2023-01-23", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "941281"}, "abstract": "SARS-CoV-2 continues to pose a threat to human health as new variants emerge and thus a diverse vaccine pipeline is needed. We evaluated SARS-CoV-2 HexaPro spike protein formulated in Alhydrogel\u00ae (aluminium oxyhydroxide) in Syrian hamsters, using an accelerated two dose regimen (given 10 days apart) and a standard regimen (two doses given 21 days apart). Both regimens elicited spike- and RBD-specific IgG antibody responses of similar magnitude, but in vitro virus neutralization was low or undetectable. Despite this, the accelerated two dose regimen offered reduction in viral load and protected against lung pathology upon challenge with homologous SARS-CoV-2 virus (Wuhan-Hu-1). This highlights that vaccine-induced protection against SARS-CoV-2 disease can be obtained despite low neutralizing antibody levels and suggests that accelerated vaccine schedules may be used to confer rapid protection against SARS-CoV-2 disease.", "doi": "10.3389/fimmu.2023.941281", "pmid": "36756130", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Funder: H2020": null}, "xrefs": [{"db": "pmc", "key": "PMC9900178"}, {"db": "URL", "key": "https://www.frontiersin.org/articles/10.3389/fimmu.2023.941281/full#supplementary-material", "description": "https://www.frontiersin.org/articles/10.3389/fimmu.2023.941281/full#supplementary-material"}], "notes": [], "created": "2023-02-13T17:53:06.820Z", "modified": "2023-02-13T17:54:54.510Z"}, {"entity": "publication", "iuid": "6263ba1c3fc449cf85ef048c256bf1b8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6263ba1c3fc449cf85ef048c256bf1b8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6263ba1c3fc449cf85ef048c256bf1b8"}}, "title": "Unravelling the link between sleep and mental health during the COVID-19 pandemic.", "authors": [{"family": "Gonz\u00e1lez-Hij\u00f3n", "given": "Juan", "initials": "J"}, {"family": "K\u00e4hler", "given": "Anna K", "initials": "AK"}, {"family": "Frans", "given": "Emma M", "initials": "EM"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Lovik", "given": "Anik\u00f3", "initials": "A", "orcid": "0000-0002-6397-5011", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e50d5a79a1234cd79b22ec2eebf6f410.json"}}], "type": "journal article", "published": "2023-01-17", "journal": {"title": "Stress Health", "issn": "1532-2998", "issn-l": null}, "abstract": "The emergence of COVID-19 brought unparalleled changes in people's lifestyle, including sleep. We aimed to assess the bidirectional association between sleep quality and mental health and describe how sleep and mental health were affected in Sweden during the COVID-19 pandemic (between June 2020 and September 2021). Data were obtained from the Omtanke2020 study. Participants who completed the baseline survey and each of the 8 monthly follow-up surveys were included (N = 9035). We described the distribution of sleep and mental health in the different Swedish regions using maps and over the study period with longitudinal graphs adjusting for sex, age, recruitment type (self-recruitment or invitation), and COVID-19 status. The inner relationships between mental health, sleep and Covid infection were described through relative importance networks. Finally, we modelled how mental health affects sleep and vice versa using generalized estimating equations with different adjustments. Seasonal and north-south regional variations were found in sleep and mental health outcomes at baseline and attenuated over time. The seasonal variation of sleep and mental health correlated moderately with the incidence rate of COVID-19 in the sample. Networks indicate that the relationship between COVID-19 incidence and mental health varies over time. We observed a bidirectional relationship between sleep quality and quantity at baseline and mental health at follow-up and vice versa. Sleep quality and quantity at baseline was associated with adverse symptom trajectories of mental health at follow-up, and vice versa, during the COVID-19 pandemic. There was also a weak relationship between COVID-19 incidence, sleep, and mental health.", "doi": "10.1002/smi.3223", "pmid": "36649144", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2023-02-13T18:38:35.800Z", "modified": "2023-02-13T18:38:35.856Z"}, {"entity": "publication", "iuid": "13722195d5c8437dbbf2df53eb0ded2e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13722195d5c8437dbbf2df53eb0ded2e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13722195d5c8437dbbf2df53eb0ded2e"}}, "title": "How Sweden approached the COVID-19 pandemic: Summary and commentary on the National Commission Inquiry.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF", "orcid": "0000-0003-1024-5602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1d5e45881a7469ca20a0eb360d891cc.json"}}], "type": "journal article", "published": "2023-01-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": "112", "issue": "1", "pages": "19-33", "issn-l": "0803-5253"}, "abstract": "Sweden initially chose a different disease prevention and control path during the pandemic than many other European countries. In June 2020, the Swedish Government established a National Commission to examine the management of COVID-19 in Sweden. This paper summarises, and discusses, its findings.\n\nThree reports published by the Commission were analysed. The first focused on the care of older people during the pandemic. The second examined disease and infection transmission and control and health care and public health. The third updated the first two reports and also covered economic aspects, crisis management and public communication.\n\nBy 25 February 2022, when the final report was published, 15 800 individuals, 1.5 per 1000 Swedish inhabitants, had died after COVID-19. The death rates were high in spring 2020, but overall excess mortality in 2020-2021 was +0.79%, which was lower than in many other European countries. The Commission suggested that the voluntary measures that were adopted were appropriate and maintained Swedes' personal freedom during the pandemic. However, more extensive and earlier measures should have been taken, especially during the first wave.\n\nThe Swedish COVID-19 Commission felt that earlier and more extensive pandemic action should have been taken, particularly during the first wave.", "doi": "10.1111/apa.16535", "pmid": "36065136", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC9538368"}], "notes": [], "created": "2023-01-13T13:25:04.669Z", "modified": "2023-07-13T11:27:39.751Z"}, {"entity": "publication", "iuid": "c407248f73de4d6e942cd708071d48be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c407248f73de4d6e942cd708071d48be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c407248f73de4d6e942cd708071d48be"}}, "title": "Specific Physiotherapy for Persons in the Post-Acute Phase after Moderate-To-Severe COVID-19: An Experimental Multiple-Baseline Single-Case Study", "authors": [{"family": "Azzabi", "given": "Susann", "initials": "S"}, {"family": "Jones", "given": "Christine", "initials": "C"}, {"family": "S\u00f6derlund", "given": "Anne", "initials": "A"}, {"family": "Nordgren", "given": "Lena", "initials": "L"}], "type": "posted-content", "published": "2023-00-00", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.2139/ssrn.4441260", "pmid": null, "labels": {"Category: Social Science & Humanities": null, "Type: Preprint": null, "Category: Rehabilitation": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:09:58.825Z", "modified": "2023-10-04T06:27:31.281Z"}, {"entity": "publication", "iuid": "a389b5e780ef4cd6b27bcd9c402dd4b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a389b5e780ef4cd6b27bcd9c402dd4b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a389b5e780ef4cd6b27bcd9c402dd4b9"}}, "title": "Mortality in Norway and Sweden During the COVID-19 Pandemic 2020 \u2013 22: A Comparative Study", "authors": [{"family": "Zahl", "given": "Per Henrik", "initials": "PH"}, {"family": "Hemstr\u00f6m", "given": "\u00d6rjan", "initials": "\u00d6"}, {"family": "Johansen", "given": "Rune", "initials": "R"}, {"family": "Mamalund", "given": "Svenn Erik", "initials": "SE"}], "type": "posted-content", "published": "2023-00-00", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.2139/ssrn.4449686", "pmid": null, "labels": {"Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:08:36.783Z", "modified": "2023-10-04T05:16:03.167Z"}, {"entity": "publication", "iuid": "2d56c9b15d764223911a21487cb759e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d56c9b15d764223911a21487cb759e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d56c9b15d764223911a21487cb759e2"}}, "title": "Mitigating Oil Price Volatility Amidst the COVID-19 Pandemic: Leveraging Metal Hedging Strategies with Market Uncertainty", "authors": [{"family": "Hussain", "given": "Saddam", "initials": "S"}, {"family": "Hussain", "given": "Sajid", "initials": "S"}], "type": "posted-content", "published": "2023-00-00", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.2139/ssrn.4515282", "pmid": null, "labels": {"Type: Preprint": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:09:37.410Z", "modified": "2023-10-04T12:59:12.155Z"}, {"entity": "publication", "iuid": "58ba0c3206a0408790805f45ada75fc7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/58ba0c3206a0408790805f45ada75fc7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/58ba0c3206a0408790805f45ada75fc7"}}, "title": "Differential Immunometabolism and Tissue Responses to Delta and Omicron SARS-CoV-2 Variants in Golden Syrian Hamster Models", "authors": [{"family": "Rajaiah", "given": "Rajesh", "initials": "R"}, {"family": "Pandey", "given": "Kabita", "initials": "K"}, {"family": "Ambikan", "given": "Anoop T", "initials": "AT"}, {"family": "Kumar", "given": "Narendra", "initials": "N"}, {"family": "Guda", "given": "Reema", "initials": "R"}, {"family": "Montaner", "given": "Luis", "initials": "L"}, {"family": "Cohen", "given": "Samuel M", "initials": "SM"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}, {"family": "Byrareddy", "given": "Siddappa", "initials": "S"}], "type": "posted-content", "published": "2023-00-00", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.2139/ssrn.4554600", "pmid": null, "labels": {"Type: Preprint": null, "Category: Other": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:55:21.475Z", "modified": "2023-10-06T10:51:17.531Z"}, {"entity": "publication", "iuid": "e251a5b1eb9c4da29ae1ac53e88d79d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e251a5b1eb9c4da29ae1ac53e88d79d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e251a5b1eb9c4da29ae1ac53e88d79d5"}}, "title": "Dexamethasone Treatment for COVID-19 is Related with Increased Mortality in Haematological Malignancy Patients: Results from the EPICOVIDEHA Registry", "authors": [{"family": "Aiello", "given": "Tommaso Francesco", "initials": "TF"}, {"family": "Salmanton-Garcia", "given": "Jon", "initials": "J"}, {"family": "Marchesi", "given": "Francesco", "initials": "F"}, {"family": "Weinbergerova", "given": "Barbora", "initials": "B"}, {"family": "Glenthoj", "given": "Andreas", "initials": "A"}, {"family": "Van Praet", "given": "Jens", "initials": "J"}, {"family": "Farina", "given": "Francesca", "initials": "F"}, {"family": "Davila-Valls", "given": "Julio", "initials": "J"}, {"family": "Mart\u00edn-P\u00e9rez", "given": "Sonia", "initials": "S"}, {"family": "El-Ashwah", "given": "Shaimaa", "initials": "S"}, {"family": "Sch\u00f6nlein", "given": "Martin", "initials": "M"}, {"family": "Falces-Romero", "given": "Iker", "initials": "I"}, {"family": "Labrador", "given": "Jorge", "initials": "J"}, {"family": "Sili", "given": "Uluhan", "initials": "U"}, {"family": "Buquicchio", "given": "Caterina", "initials": "C"}, {"family": "Vena", "given": "Antonio", "initials": "A"}, {"family": "Plantefeve", "given": "Gaetan", "initials": "G"}, {"family": "Petzer", "given": "Verena", "initials": "V"}, {"family": "Biernat", "given": "Monika M", "initials": "MM"}, {"family": "Lahmer", "given": "Tobias", "initials": "T"}, {"family": "Espigado", "given": "Ildefonso", "initials": "I"}, {"family": "van Doesum", "given": "Jaap A", "initials": "JA"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Piukovics", "given": "Kl\u00e1ra", "initials": "K"}, {"family": "Tascini", "given": "Carlo", "initials": "C"}, {"family": "Samarkos", "given": "Michael", "initials": "M"}, {"family": "Bilgin", "given": "Yavuz M", "initials": "YM"}, {"family": "Fianchi", "given": "Luana", "initials": "L"}, {"family": "Itri", "given": "Federico", "initials": "F"}, {"family": "Valkovic", "given": "Toni", "initials": "T"}, {"family": "Fracchiolla", "given": "Nicola S", "initials": "NS"}, {"family": "Dargenio", "given": "Michelina", "initials": "M"}, {"family": "Jimenez", "given": "Moraima", "initials": "M"}, {"family": "Magyari", "given": "Ferenc", "initials": "F"}, {"family": "Lopez-Garcia", "given": "Alberto", "initials": "A"}, {"family": "Prezioso", "given": "Lucia", "initials": "L"}, {"family": "\u010colovic", "given": "Natasa", "initials": "N"}, {"family": "Shumilov", "given": "Evgenii", "initials": "E"}, {"family": "Abu-Zeinah", "given": "Ghaith", "initials": "G"}, {"family": "Lavilla-Rubira", "given": "Esperanza", "initials": "E"}, {"family": "Papa", "given": "Mario Virgilio", "initials": "MV"}, {"family": "Lopez-Gonzalez", "given": "Tom\u00e1s Jos\u00e9", "initials": "TJ"}, {"family": "Pinczes", "given": "L\u00e1szl\u00f3 Imre", "initials": "LI"}, {"family": "Demirkan", "given": "Fatih", "initials": "F"}, {"family": "Ali", "given": "Natasha", "initials": "N"}, {"family": "Besson", "given": "Caroline", "initials": "C"}, {"family": "Fouquet", "given": "Guillemette", "initials": "G"}, {"family": "Romano", "given": "Alessandra", "initials": "A"}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jose Angel", "initials": "JA"}, {"family": "del Principe", "given": "Maria Ilaria", "initials": "MI"}, {"family": "Aujayeb", "given": "Avinash", "initials": "A"}, {"family": "Merelli", "given": "Maria", "initials": "M"}, {"family": "Lamure", "given": "Sylvain", "initials": "S"}, {"family": "Marques De Almeida", "given": "Joyce", "initials": "J"}, {"family": "Gomes da Silva", "given": "Maria", "initials": "M"}, {"family": "Eisa", "given": "Noha", "initials": "N"}, {"family": "Meletiadis", "given": "Joseph", "initials": "J"}, {"family": "Rinaldi", "given": "Ikhwan", "initials": "I"}, {"family": "Finizio", "given": "Olimpia", "initials": "O"}, {"family": "Jak\u0161i\u0107", "given": "Ozren", "initials": "O"}, {"family": "Delia", "given": "Mario", "initials": "M"}, {"family": "Nizamuddin", "given": "Summiya", "initials": "S"}, {"family": "Marchetti", "given": "Monia", "initials": "M"}, {"family": "Machado", "given": "Marina", "initials": "M"}, {"family": "Cernan", "given": "Martin", "initials": "M"}, {"family": "Coppola", "given": "Nicola", "initials": "N"}, {"family": "Gavriilaki", "given": "Eleni", "initials": "E"}, {"family": "Cattaneo", "given": "Chiara", "initials": "C"}, {"family": "Groh", "given": "Ana", "initials": "A"}, {"family": "Stojanoski", "given": "Zlate", "initials": "Z"}, {"family": "Erben", "given": "Nurettin", "initials": "N"}, {"family": "Pantic", "given": "Nikola", "initials": "N"}, {"family": "Mendez", "given": "Gustavo Adolfo", "initials": "GA"}, {"family": "Di Blasi", "given": "Roberta", "initials": "R"}, {"family": "Meers", "given": "Stef", "initials": "S"}, {"family": "De Ramon", "given": "Cristina", "initials": "C"}, {"family": "Bahr", "given": "Nathan C", "initials": "NC"}, {"family": "Emarah", "given": "Ziad", "initials": "Z"}, {"family": "Varricchio", "given": "Gina", "initials": "G"}, {"family": "Cvetanoski", "given": "Milche", "initials": "M"}, {"family": "Garcia-Sanz", "given": "Ram\u00f3n", "initials": "R"}, {"family": "Mitrovic", "given": "Mirjana", "initials": "M"}, {"family": "Lievin", "given": "Rapha\u00ebl", "initials": "R"}, {"family": "Hanakova", "given": "Michaela", "initials": "M"}, {"family": "Racil", "given": "Zden\u011bk", "initials": "Z"}, {"family": "Vehreschild", "given": "Maria", "initials": "M"}, {"family": "Tragiannidis", "given": "Athanasios", "initials": "A"}, {"family": "Nunes Rodrigues", "given": "Raquel", "initials": "R"}, {"family": "Garcia-Bordallo", "given": "Daniel", "initials": "D"}, {"family": "Cordoba", "given": "Raul", "initials": "R"}, {"family": "Cabirta", "given": "Alba", "initials": "A"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Ammatuna", "given": "Emanuele", "initials": "E"}, {"family": "Arellano", "given": "Elena", "initials": "E"}, {"family": "Wolf", "given": "Dominik", "initials": "D"}, {"family": "Prin", "given": "Romane", "initials": "R"}, {"family": "Limongelli", "given": "Alessandro", "initials": "A"}, {"family": "Bavastro", "given": "Martina", "initials": "M"}, {"family": "\u00c7olak", "given": "G\u00f6k\u00e7e Melis", "initials": "GM"}, {"family": "Grafe", "given": "Stefanie K", "initials": "SK"}, {"family": "Hersby", "given": "Ditte Stampe", "initials": "DS"}, {"family": "Rahimli", "given": "Laman", "initials": "L"}, {"family": "Cornely", "given": "Oliver A", "initials": "OA"}, {"family": "Garcia-Vidal", "given": "Carolina", "initials": "C"}, {"family": "Pagano", "given": "Livio", "initials": "L"}], "type": "posted-content", "published": "2023-00-00", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.2139/ssrn.4473151", "pmid": null, "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:31:55.616Z", "modified": "2023-10-04T10:58:26.841Z"}, {"entity": "publication", "iuid": "2984715e091b41cca10d0afc09010d9d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2984715e091b41cca10d0afc09010d9d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2984715e091b41cca10d0afc09010d9d"}}, "title": "Critical Flows Throughout the Covid-19 Pandemic \u2013 a Longitudinal Study on Interdependencies and Resilience in a Swedish Context", "authors": [{"family": "Lindstr\u00f6m M\u00e5nefjord", "given": "Josefin", "initials": "J"}, {"family": "Johansson", "given": "Jonas", "initials": "J"}], "type": "posted-content", "published": "2023-00-00", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.2139/ssrn.4510064", "pmid": null, "labels": {"Category: Other": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:09:32.247Z", "modified": "2023-10-04T12:56:33.856Z"}, {"entity": "publication", "iuid": "44df84b7a2b14cd399c660a2dcc50182", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44df84b7a2b14cd399c660a2dcc50182.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44df84b7a2b14cd399c660a2dcc50182"}}, "title": "Morphological changes without histological myocarditis in hearts of COVID-19 deceased patients", "authors": [{"family": "Razaghi", "given": "Ali", "initials": "A"}, {"family": "Szakos", "given": "Attila", "initials": "A"}, {"family": "Al-Shakarji", "given": "Riham", "initials": "R"}, {"family": "Bj\u00f6rnstedt", "given": "Mikael", "initials": "M"}, {"family": "Szekely", "given": "Laszlo", "initials": "L"}], "type": "journal-article", "published": "2022-12-31", "journal": {"title": "Scandinavian Cardiovascular Journal", "issn": "1401-7431", "volume": "56", "issue": "1", "pages": "166-173", "issn-l": null}, "abstract": "Objective. Patients with underlying heart diseases have a higher risk of dying from Covid-19. It has also been suggested that Covid-19 affects the heart through myocarditis. Despite the rapidly growing research on the management of Covid-19 associated complications, most of the ongoing research is focused on the respiratory complications of Covid-19, and little is known about the prevalence of myocarditis. Design. This study aimed to characterize myocardial involvement by using a panel of antibodies to detect hypoxic and inflammatory changes and the presence of SARS-CoV-2 proteins in heart tissues obtained during the autopsy procedure of Covid-19 deceased patients. Thirty-seven fatal COVID-19 cases and 21 controls were included in this study. Results. Overall, the Covid-19 hearts had several histopathological changes like the waviness of myocytes, fibrosis, contract band necrosis, infiltration of polymorphonuclear neutrophils, vacuolization, and necrosis of myocytes. In addition, endothelial damage and activation were detected in heart tissue. However, viral replication was not detected using RNA in situ hybridization. Also, lymphocyte infiltration, as a hallmark of myocarditis, was not seen in this study. Conclusion. No histological sign of myocarditis was detected in any of our cases; our findings are thus most congruent with the hypothesis of the presence of a circulating endothelium activating factor such as VEGF, originating outside of the heart, probably from the hypoxic part of the Covid-19 lungs.", "doi": "10.1080/14017431.2022.2085320", "pmid": "35678649", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-20T19:29:44.814Z", "modified": "2022-08-19T06:01:01.560Z"}, {"entity": "publication", "iuid": "91d6e059b7e14aab921dec6d04124589", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/91d6e059b7e14aab921dec6d04124589.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/91d6e059b7e14aab921dec6d04124589"}}, "title": "Burden of vaccine-preventable diseases, trends in vaccine coverage and current challenges in the implementation of the expanded program on immunization: A situation analysis of Cameroon.", "authors": [{"family": "Ngwa", "given": "Che Henry", "initials": "CH", "orcid": "0000-0003-1984-7909", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/994a7153e4de4496ace403a940cb7fb5.json"}}, {"family": "Doungtsop", "given": "Brigitte-Carole Keumatio", "initials": "BK"}, {"family": "Bihnwi", "given": "Rengerline", "initials": "R"}, {"family": "Ngo", "given": "Ngo Valery", "initials": "NV"}, {"family": "Yang", "given": "Niendum Mediatrice", "initials": "NM"}], "type": "journal article", "published": "2022-12-31", "journal": {"title": "Hum Vaccin Immunother", "issn": "2164-554X", "issn-l": null, "volume": "18", "issue": "1", "pages": "1939620"}, "abstract": "The discovery and development of vaccines remain one of the major successes of global health with millions of lives saved every year through routine vaccination. Although vaccines provide a safe and cost-effective solution to vaccine-preventable diseases (VPDs), VPDs are still a serious public health problem in most parts of the world, especially in sub-Saharan Africa (SSA) and Asia. In this review, we discuss the burden of VPDs and vaccine coverage several decades after the introduction of the Expanded Program on Immunization (EPI) in Cameroon. We also discuss how different factors affect the implementation of the EPI, highlighting context-specific factors such as the ongoing civil conflict in Cameroon, and the presence of other infectious diseases like COVID-19.", "doi": "10.1080/21645515.2021.1939620", "pmid": "34197271", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8920166"}], "notes": [], "created": "2021-07-05T14:32:04.699Z", "modified": "2023-06-19T15:16:12.262Z"}, {"entity": "publication", "iuid": "1ffb34167f6b46bdb4027e74167a09c7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ffb34167f6b46bdb4027e74167a09c7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ffb34167f6b46bdb4027e74167a09c7"}}, "title": "Sweden's Pandemic Experiment", "authors": [{"family": "Bergmans", "given": "S", "initials": "S"}, {"family": "Lindstr\u00f6m", "given": "M", "initials": "M"}], "type": null, "published": "2022-12-19", "journal": {"title": null, "issn": "ISBN 9781032266718", "issn-l": null, "volume": null, "issue": null, "pages": "322"}, "abstract": "This book considers Sweden\u2019s pandemic management which differed so significantly from much of the rest of the world: it provoked intense and wide-reaching interest, curiosity and criticism. Trans-disciplinary Swedish authors from the humanities, life sciences, social sciences, and cultural studies use a variety of tools to mine deeper into some of the central elements and dimensions in their country\u2019s pandemic management such as understandings of freedom, the execution of power, denialism, exceptionalism, patriotism, the role of expertise and trust in the national state to give a deeper understanding of Sweden\u2019s decisions, failures, successes, and the lessons to be learned.\r\nAimed at readers with interest in global health and politics it will also be of interest in disciplines such as virology,epidemiology, history, cultural studies, ethics, media studies, medicine and economics.\r\nThe Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives.", "doi": "https://doi.org/10.4324/9781003289364", "pmid": null, "labels": {"Type: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-01-16T15:35:40.815Z", "modified": "2023-02-23T06:16:16.600Z"}, {"entity": "publication", "iuid": "3bbafb7e92c0416d8fb72a56545e31c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3bbafb7e92c0416d8fb72a56545e31c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3bbafb7e92c0416d8fb72a56545e31c5"}}, "title": "Re-evaluating Our Knowledge of Health System Resilience During COVID-19: Lessons From the First Two Years of the Pandemic.", "authors": [{"family": "Saulnier", "given": "Dell D", "initials": "DD", "orcid": "0000-0001-7761-0737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d3fc961101845b1ae844339af7495e4.json"}}, {"family": "Duchenko", "given": "Anna", "initials": "A"}, {"family": "Ottilie-Kovelman", "given": "Sierra", "initials": "S"}, {"family": "Tediosi", "given": "Fabrizio", "initials": "F", "orcid": "0000-0001-8671-9400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9884188f9c04312b05212ade939818d.json"}}, {"family": "Blanchet", "given": "Karl", "initials": "K", "orcid": "0000-0003-0498-8020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aad004843f3f44c8b011feedf86831e1.json"}}], "type": "review", "published": "2022-12-06", "journal": {"title": "Int J Health Policy Manag", "issn": "2322-5939", "issn-l": null, "volume": "12", "issue": null, "pages": "6659"}, "abstract": "Health challenges like coronavirus disease 2019 (COVID-19) are becoming increasingly complex, transnational, and unpredictable. Studying health system responses to the COVID-19 pandemic is an opportunity to enhance our understanding of health system resilience and establish a clearer link between theoretical concepts and practical ideas on how to build resilience.\r\n\r\nThis narrative literature review aims to address four questions using a health system resilience framework: (i) What do we understand about the dimensions of resilience? (ii) What aspects of the resilience dimensions remain uncertain? (iii) What aspects of the resilience dimensions are missing from the COVID-19 discussions? and (iv) What has COVID-19 taught us about resilience that is missing from the framework? A scientific literature database search was conducted in December 2020 and in April 2022 to identify publications that discussed health system resilience in relation to COVID-19, excluding articles on psychological and other types of resilience. A total of 63 publications were included.\r\n\r\nThere is good understanding around information sharing, flexibility and good leadership, learning, maintaining essential services, and the need for legitimate, interdependent systems. Decision-making, localized trust, influences on interdependence, and transformation remain uncertain. Vertical interdependence, monitoring risks beyond the health system, and consequences of changes on the system were not discussed. Teamwork, actor legitimacy, values, inclusivity, trans-sectoral resilience, and the role of the private sector are identified as lessons from COVID-19 that should be further explored for health system resilience.\r\n\r\nKnowledge of health system resilience has continued to cohere following the pandemic. The eventual consequences of system changes and the resilience of subsystems are underexplored. Through governance, the concept of health system resilience can be linked to wider issues raised by the pandemic, like inclusivity. Our findings show the utility of resilience theory for strengthening health systems for crises and the benefit of continuing to refine existing resilience theory.", "doi": "10.34172/ijhpm.2022.6659", "pmid": "37579465", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC10125099"}, {"db": "pii", "key": "6659"}], "notes": [], "created": "2023-10-05T08:26:23.977Z", "modified": "2023-10-06T04:58:17.047Z"}, {"entity": "publication", "iuid": "b3e56804818b4607b3846fdce98963cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b3e56804818b4607b3846fdce98963cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b3e56804818b4607b3846fdce98963cc"}}, "title": "Effectiveness of COVID-19 Vaccines over 13 Months Covering the Period of the Emergence of the Omicron Variant in the Swedish Population.", "authors": [{"family": "Xu", "given": "Yiyi", "initials": "Y", "orcid": "0000-0001-9106-0049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06663aac11174e88a79cbb8e2ec4f3c0.json"}}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Kirui", "given": "Brian", "initials": "B", "orcid": "0000-0002-6656-6029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b22b96547b344c79b3780723af1f30e0.json"}}, {"family": "Santosa", "given": "Ailiana", "initials": "A", "orcid": "0000-0002-1848-2867", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/049cb4da029a4e7491b6914f93e8bf17.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}, {"family": "Leach", "given": "Susannah", "initials": "S", "orcid": "0000-0002-9614-2753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18d00be831d241dca238b3253d1b45f6.json"}}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW", "orcid": "0000-0002-4387-4096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bb5d1f761ef48c4837ed4f984717f0e.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2022-12-05", "journal": {"title": "Vaccines", "issn": "2076-393X", "issn-l": null, "volume": "10", "issue": "12", "pages": null}, "abstract": "We estimated real-world vaccine effectiveness (VE) against COVID-19 infection, hospitalization, ICU admission, and death up to 13 months after vaccination. VE before and after the emergence of Omicron was investigated.\r\n\r\nWe used registered data from the entire Swedish population above age 12 (n = 9,153,456). Cox regression with time-varying exposure was used to estimate weekly/monthly VE against COVID-19 outcomes from 27 December 2020 to 31 January 2022. The analyses were stratified by age, sex, and vaccine type (BNT162b2, mRNA-1273, and AZD1222).\r\n\r\nTwo vaccine doses offered good long-lasting protection against infection before Omicron (VE were above 85% for all time intervals) but limited protection against Omicron infection (dropped to 43% by week four and no protection by week 14). For severe COVID-19 outcomes, higher VE was observed during the entire follow-up period. Among individuals above age 65, the mRNA vaccines showed better VE against infection than AZD1222 but similar high VE against hospitalization.\r\n\r\nOur findings provide strong evidence for long-term maintained protection against severe COVID-19 by the basic two-dose schedule, supporting more efforts to encourage unvaccinated persons to get the basic two doses, and encourage vaccinated persons to get a booster to ensure better population-level protection.", "doi": "10.3390/vaccines10122074", "pmid": "36560484", "labels": {"Category: Omicron VoC": null, "Category: Vaccines": null, "Category: Health": null, "Type: Journal article": null, "Research Area: Vaccine": null, "Funder: KAW/SciLifeLab": null, "Topics: Register-based research": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC9782222"}, {"db": "pii", "key": "vaccines10122074"}], "notes": [], "created": "2023-01-11T07:10:07.512Z", "modified": "2023-01-13T10:03:13.606Z"}, {"entity": "publication", "iuid": "e9d5aabd4b404ca2a149b7d83644bbc2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e9d5aabd4b404ca2a149b7d83644bbc2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e9d5aabd4b404ca2a149b7d83644bbc2"}}, "title": "Dying during the COVID-19 Pandemic in Sweden: Relatives' Experiences of End-of-Life Care (the CO-LIVE Study).", "authors": [{"family": "Hedman", "given": "Christel", "initials": "C", "orcid": "0000-0003-4183-7598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f207650ce40e46e5b3ab9d7b716684e7.json"}}, {"family": "F\u00fcrst", "given": "Carl Johan", "initials": "CJ"}, {"family": "Rasmussen", "given": "Birgit H", "initials": "BH", "orcid": "0000-0003-0830-6058", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb3b0176d4654420acbc791974c7cb36.json"}}, {"family": "van der Heide", "given": "Agnes", "initials": "A"}, {"family": "Schelin", "given": "Maria E C", "initials": "MEC"}], "type": "journal article", "published": "2022-12-02", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "23", "issn-l": null}, "abstract": "The COVID-19 pandemic has seen many deaths, but the majority were for causes other than COVID-19. However, end-of-life care in all settings has been affected by measures limiting the spread of the virus, for patients with and without COVID-19. The Swedish coronavirus strategy was different compared to many other countries, which might have affected end-of-life care. The aim was to describe the experiences of end-of-life care for bereaved relatives in Sweden during the \"first wave\" and to compare the experiences for deaths due to COVID-19 with the experiences for deaths for other reasons.\n\nA random sample of addresses for 2400 people who died during March-September 2020 was retrieved from the Swedish Person Address Registry. Relatives were contacted with a questionnaire regarding their experience of end-of-life care, with a focus on communication, participation, and trust.\n\nIn total, 587 relatives (25% response rate) answered the questionnaire (14% COVID-19-deaths, 65% non-COVID-19-deaths, 21% uncertain). In the COVID-19 group 28% of the relatives were allowed visits without restrictions compared to 60% in the non-COVID-19 group (p &lt; 0.01). Only 28% of the relatives in the COVID-19 group reported that the person received \"enough care from physicians\", significantly fewer than the non-COVID group (65%, p &lt; 0.01).\n\nRelatives' experience of end-of-life care for persons with COVID-19 was significantly worse than relatives of persons without COVID-19, but relatives for persons without COVID-19 were also negatively affected.", "doi": "10.3390/ijerph192316146", "pmid": "36498221", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9740982"}, {"db": "pii", "key": "ijerph192316146"}], "notes": [], "created": "2023-01-13T13:30:38.545Z", "modified": "2023-01-13T13:30:38.625Z"}, {"entity": "publication", "iuid": "01d0dfdb226e48828101c520ca11852b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01d0dfdb226e48828101c520ca11852b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01d0dfdb226e48828101c520ca11852b"}}, "title": "The significance of the COVID-19 pandemic for family caregivers of non-COVID-19 patients in need of specialized palliative care at home: a qualitative study.", "authors": [{"family": "Wind", "given": "Gitte", "initials": "G", "orcid": "0000-0002-4907-4225", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59fa80d82c57425cb5654bae8f943cbf.json"}}, {"family": "Vedsegaard", "given": "Helle Wendner", "initials": "HW", "orcid": "0000-0003-0642-0877", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc7be809bef544df89b4aaab46a2de36.json"}}, {"family": "Marsaa", "given": "Kristoffer", "initials": "K", "orcid": "0000-0001-7366-7533", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fb03be244644237ba3eb1a308b13e9d.json"}}, {"family": "True", "given": "Trine Solander", "initials": "TS", "orcid": "0000-0003-4778-3340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ea4a7e652b146fb8949ee69454cca77.json"}}, {"family": "Konradsen", "given": "Hanne", "initials": "H", "orcid": "0000-0002-7477-125X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b462d15cdeec4dcb8371e07cf2e97853.json"}}], "type": "journal article", "published": "2022-12-00", "journal": {"title": "Int J Qual Stud Health Well-being", "issn": "1748-2631", "volume": "17", "issue": "1", "pages": "2113021", "issn-l": null}, "abstract": "It is well known that being a family caregiver of a palliative patient in general is rewarding as well as burdensome. The COVID-19 pandemic may have exacerbated this situation. We therefore explored the significance of the COVID-19 pandemic for family caregivers of non-COVID-19 patients in need of specialized palliative care at home.\n\nOpen-ended, semi-structured telephone interviews were conducted with 15 family caregivers of patients treated by a specialized palliative outpatient unit in a Danish hospital. Interviews were analysed using inductive thematic analysis.\n\nFour themes concerning the significance of the COVID-19 pandemic were identified: 1) being a family caregiver of a patient whose lifespan is already limited, 2) dealing with the risk of passing on COVID-19 oneself, 3) dealing with the risk of others passing on COVID-19 to the patient at home, and 4) living with modified specialized palliative care.\n\nThe COVID-19 pandemic had a radical impact on some family caregivers causing emotional despair. They feared not only infecting the patient with SARS-CoV-2 to cause an untimely death but also being unable to be there for the patient during hospitalization, especially in the patient's final days.", "doi": "10.1080/17482631.2022.2113021", "pmid": "35979626", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9397423"}], "notes": [], "created": "2022-09-12T18:41:52.197Z", "modified": "2022-09-12T18:42:07.522Z"}, {"entity": "publication", "iuid": "192bd823143141d99c5ce6074b66c9cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/192bd823143141d99c5ce6074b66c9cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/192bd823143141d99c5ce6074b66c9cf"}}, "title": "Continuation of fibrate therapy in patients with metabolic syndrome and COVID-19: a beneficial regime worth pursuing.", "authors": [{"family": "Vuorio", "given": "Alpo", "initials": "A", "orcid": "0000-0002-5504-2959", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ced6a984e09a43b2805f1bc49faedaa1.json"}}, {"family": "Brinck", "given": "Jonas", "initials": "J"}, {"family": "Kovanen", "given": "Petri T", "initials": "PT", "orcid": "0000-0002-2532-367X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84f610f43369437ba754d852866a83dd.json"}}], "type": "journal article", "published": "2022-12-00", "journal": {"title": "Ann Med", "issn": "1365-2060", "volume": "54", "issue": "1", "pages": "1952-1955", "issn-l": null}, "abstract": "Based on separate protective mechanisms related to lipid metabolism, viral cell entry and inflammation, fibrate treatment might be advantageous among patients who have been taking fibrates before SARS-CoV-2 infection and continue taking them during the infection. Based on published data on hospitalized COVID-19 patients, we recommend that the clinicians should ask their patients with metabolic syndrome who are already taking fibrates to continue fibrate treatment during the COVID-19 illness. This recommendation applies to both outpatients and hospitalized patients. However, results from the ongoing randomized controlled trials (RCTs) using fenofibrate treatment for the prevention or treatment of COVID-19 have yet to prove that fenofibrate is clinically significant for this indication.KEY MESSAGESThe role of fibrates as a repurpose to treat SARS-CoV-2 is under investigation in at least three ongoing RCTs.Obesity, diabetes, hypertension and dyslipidaemia, individually or clustered as a discrete phenotype, the metabolic syndrome, typically associate with a more severe course of COVID-19.Fibrate treatment seems to be most advantageous among patients who have been taken fibrates before SARS-CoV-2 infection and are continuing to take them during the infection.We recommend that the clinicians encourage their patients who are already taking fibrate to continue using the drug throughout the COVID-19 illness.", "doi": "10.1080/07853890.2022.2095667", "pmid": "35818956", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9278418"}], "notes": [], "created": "2022-08-17T10:37:58.554Z", "modified": "2022-08-17T10:37:58.676Z"}, {"entity": "publication", "iuid": "960c8cf80a514f20bcaaede734be70f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/960c8cf80a514f20bcaaede734be70f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/960c8cf80a514f20bcaaede734be70f4"}}, "title": "Considering medical students' perception, concerns and needs for e-exam during COVID-19: a promising approach to improve subject specific e-exams.", "authors": [{"family": "Ziehfreund", "given": "Stefanie", "initials": "S", "orcid": "0000-0003-3176-1120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce3b717d48094ef79f02636755ea893a.json"}}, {"family": "Reifenrath", "given": "Johannes", "initials": "J"}, {"family": "Wijnen-Meijer", "given": "Marjo", "initials": "M"}, {"family": "Welzel", "given": "Julia", "initials": "J"}, {"family": "Sauter", "given": "Fabian", "initials": "F"}, {"family": "Wecker", "given": "Hannah", "initials": "H"}, {"family": "Biedermann", "given": "Tilo", "initials": "T"}, {"family": "Zink", "given": "Alexander", "initials": "A"}], "type": "journal article", "published": "2022-12-00", "journal": {"title": "Med Educ Online", "issn": "1087-2981", "volume": "27", "issue": "1", "pages": "2114131", "issn-l": null}, "abstract": "The COVID-19 pandemic forced a rapid shift to digital strategies including e-exams in medical schools. However, there are significant concerns, predominately from student perspectives, and further data is required to successfully establish e-assessment in the medical curricula. The objective of the study was to examine medical students' perceptions, concerns, and needs regarding e-assessment to establish a comprehensive e-exam based on these and previous findings and to evaluate its effectiveness in terms of examinee perceptions and further needs. During the 2021 summer term, a cross-sectional study using qualitative and quantitative methods was conducted among all 1077 students at the School of Medicine, Technical University of Munich. They were asked to provide information regarding their characteristics, preferred exam format, e-assessment perception, concerns, and needs in an online questionnaire. Based on these findings, a pilot e-exam including an e-exam preparation for the students were established and subsequently evaluated among 125 pilot e-exam examinees under study consideration via an online-questionnaire. Of the 317 pre-exam participants (73.2% female), 70.3% preferred in-person exams and showed concerns about the technological framework, privacy, and examination requirements. Qualitative analysis showed that these concerns lead to additional exam stress and fear of failure. The 34 (79.4% female) participants who participated in the evaluation survey showed a significantly more positive e-exam perception. The fairness of the platform, the independence from an internet connection, the organization including the e-exam preparation, and the consideration of participant needs were discussed as particularly positive in the open-ended comments. In both surveys, participants requested uniform platforms and processes for all subjects. This study provides evidence for a positive, complementary role of student participation in a successful e-exam implementation. Furthermore, when establishing an e-exam format in the medical curricula, e-exam training, equal accessibility, availability offline, and all-round fairness should be considered.", "doi": "10.1080/10872981.2022.2114131", "pmid": "35993348", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9397442"}], "notes": [], "created": "2022-09-12T18:53:10.704Z", "modified": "2022-09-12T18:53:10.829Z"}, {"entity": "publication", "iuid": "b558292026a7442ba7979879012b5a38", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b558292026a7442ba7979879012b5a38.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b558292026a7442ba7979879012b5a38"}}, "title": "Bayesian nowcasting with leading indicators applied to COVID-19 fatalities in Sweden.", "authors": [{"family": "Bergstr\u00f6m", "given": "Fanny", "initials": "F", "orcid": "0000-0002-0693-3851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fb53e3138c64a00ae6f60214d4d23b6.json"}}, {"family": "G\u00fcnther", "given": "Felix", "initials": "F"}, {"family": "H\u00f6hle", "given": "Michael", "initials": "M", "orcid": "0000-0002-0423-6702", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4c004a5b6de46d7baabeffdef938778.json"}}, {"family": "Britton", "given": "Tom", "initials": "T"}], "type": "journal article", "published": "2022-12-00", "journal": {"title": "PLoS Comput Biol", "issn": "1553-7358", "volume": "18", "issue": "12", "pages": "e1010767", "issn-l": null}, "abstract": "The real-time analysis of infectious disease surveillance data is essential in obtaining situational awareness about the current dynamics of a major public health event such as the COVID-19 pandemic. This analysis of e.g., time-series of reported cases or fatalities is complicated by reporting delays that lead to under-reporting of the complete number of events for the most recent time points. This can lead to misconceptions by the interpreter, for instance the media or the public, as was the case with the time-series of reported fatalities during the COVID-19 pandemic in Sweden. Nowcasting methods provide real-time estimates of the complete number of events using the incomplete time-series of currently reported events and information about the reporting delays from the past. In this paper we propose a novel Bayesian nowcasting approach applied to COVID-19-related fatalities in Sweden. We incorporate additional information in the form of time-series of number of reported cases and ICU admissions as leading signals. We demonstrate with a retrospective evaluation that the inclusion of ICU admissions as a leading signal improved the nowcasting performance of case fatalities for COVID-19 in Sweden compared to existing methods.", "doi": "10.1371/journal.pcbi.1010767", "pmid": "36477048", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC9762573"}, {"db": "pii", "key": "PCOMPBIOL-D-22-01107"}], "notes": [], "created": "2023-01-13T13:33:58.495Z", "modified": "2023-01-13T13:33:58.562Z"}, {"entity": "publication", "iuid": "08ccf53710c34f02a790a5405cea03b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/08ccf53710c34f02a790a5405cea03b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/08ccf53710c34f02a790a5405cea03b9"}}, "title": "Mental health outcomes following COVID-19 infection: impacts of post-COVID impairments and fatigue on depression, anxiety, and insomnia - a web survey in Sweden.", "authors": [{"family": "Badinlou", "given": "Farzaneh", "initials": "F"}, {"family": "Lundgren", "given": "Tobias", "initials": "T"}, {"family": "Jansson-Fr\u00f6jmark", "given": "Markus", "initials": "M"}], "type": "journal article", "published": "2022-11-29", "journal": {"title": "BMC Psychiatry", "issn": "1471-244X", "volume": "22", "issue": "1", "pages": "743", "issn-l": null}, "abstract": "The negative impact of the COVID-19 pandemic on the mental health is now clearly established. However, information on the levels of mental ill health of people infected with COVID-19 and potential correlates of poor mental health is still limited. Therefore, the current study aimed to study indicative of potential mental health problems in individuals with a history of probable or confirmed SARS CoV-2 infection/infections and address the impacts of post-COVID impairments and fatigue following COVID-19 infection/infections on depression, anxiety, and insomnia.\n\nA web-survey including demographics, questions related to COVID-19 status and post-COVID impairments, and standardized measures of depression, anxiety, insomnia, and fatigue was completed by 507 individuals with a history of probable or confirmed SARS CoV-2 infection/infections.\n\nWe found significant rates of significant depression, anxiety, and insomnia in our sample, with more than 70% experiencing levels above the clinical cut offs for at least one psychological health problems. Higher levels of depression, anxiety, and insomnia were associated with the severity of COVID-19 infection in the acute phase, hospitalization because of COVID-19, and higher levels of post-COVID impairments and fatigue. Reduced motivation emerged as the strongest predictor for mental ill health.\n\nThese findings highlight that individuals infected with COVID-19, especially those who still have experienced post-COVID impairments, are more likely to suffer from mental ill-health and may be more vulnerable for poor mental health outcomes. Therefore, more effective actions are needed to take in order to promote and protect mental health of individuals with a history of COVID-19 infection.", "doi": "10.1186/s12888-022-04405-0", "pmid": "36447183", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9708120"}, {"db": "pii", "key": "10.1186/s12888-022-04405-0"}], "notes": [], "created": "2023-01-13T13:49:40.950Z", "modified": "2023-01-13T13:49:40.952Z"}, {"entity": "publication", "iuid": "f2224afaa64745eca88acf3366c2efdb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f2224afaa64745eca88acf3366c2efdb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f2224afaa64745eca88acf3366c2efdb"}}, "title": "Media use and trust during the COVID-19 pandemic: evidence from eight cross-sectional surveys in Sweden.", "authors": [{"family": "Winters", "given": "Maike", "initials": "M", "orcid": "0000-0003-0915-6506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35b530d67b244b999f697b2923b32bbf.json"}}, {"family": "Biermann", "given": "Olivia", "initials": "O"}, {"family": "Bohlin", "given": "Gustav", "initials": "G"}, {"family": "Bergman", "given": "Martin", "initials": "M"}, {"family": "Broun\u00e9us", "given": "Fredrik", "initials": "F"}, {"family": "Zeebari", "given": "Zangin", "initials": "Z"}, {"family": "Nordenstedt", "given": "Helena", "initials": "H"}], "type": "journal article", "published": "2022-11-29", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "volume": "32", "issue": "6", "pages": "976-981", "issn-l": "1101-1262"}, "abstract": "While a lot has been written about Sweden's COVID-19 control strategy, less is known about Swedish residents' media use during the pandemic and trust in and perceived agreement among key stakeholders commenting in the media.\n\nEight online, nationwide surveys were fielded between March and August 2020, during the first wave of the coronavirus pandemic in Sweden, with 8146 responses. Questions were asked on media usage, perceived tone of media, trust in key pandemic stakeholder groups commenting in the media (politicians, journalists, government officials, doctors/healthcare professionals and researchers) and perceived agreement among these key stakeholders about how the pandemic was handled in Sweden.\n\nUsing five or more information sources was associated with increased perceived alarmism in the media. Women and those with tertiary education were more likely to trust key pandemic actors. Trust in doctors/healthcare professionals and researchers remained high over the course of the study, trust in politicians and journalists was relatively low throughout the study period, with a slight increase in April 2020. Trust in key stakeholders was strongly associated with perceived agreement among the key stakeholders.\n\nOur results show that trust in stakeholders was strongly associated with perceived consistency of messages from those stakeholders. The inverse also holds: perceived conflicting messages among stakeholders was associated with low trust in them. Taken together, this could point to the importance of building trust before a crisis. Trust-building efforts could be targeted to men and those with lower educational attainment, as they had lower trust in key stakeholders.", "doi": "10.1093/eurpub/ckac145", "pmid": "36223605", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC9619753"}, {"db": "pii", "key": "6759691"}], "notes": [], "created": "2023-01-13T13:55:42.245Z", "modified": "2023-01-13T13:55:42.281Z"}, {"entity": "publication", "iuid": "bae809b1d1e2474b8e24f68b4c332315", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bae809b1d1e2474b8e24f68b4c332315.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bae809b1d1e2474b8e24f68b4c332315"}}, "title": "Mucosal IgA against SARS-CoV-2 Omicron Infection. Reply.", "authors": [{"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "letter", "published": "2022-11-24", "journal": {"title": "N Engl J Med", "issn": "1533-4406", "issn-l": null, "volume": "387", "issue": "21", "pages": "e55"}, "abstract": null, "doi": "10.1056/NEJMc2213153", "pmid": "36416779", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: H2020": null, "Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "10.1056/NEJMc2213153#sa2"}], "notes": [], "created": "2022-11-25T07:15:01.636Z", "modified": "2022-11-25T07:17:36.842Z"}, {"entity": "publication", "iuid": "70c6b11ead9f439c85df5c95971b36e6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70c6b11ead9f439c85df5c95971b36e6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70c6b11ead9f439c85df5c95971b36e6"}}, "title": "Effects of COVID-19 on the Human Central Olfactory System: A Natural Pre-Post Experiment", "authors": [{"family": "Thunell", "given": "E", "initials": "E", "orcid": "0000-0002-9368-4661", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5da807e735af4a5a8a933fae9b7facc4.json"}}, {"family": "Peter", "given": "M G", "initials": "MG", "orcid": "0000-0003-4472-795X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb77dd5d98864db79f47b9c59edb3530.json"}}, {"family": "Lenoir", "given": "V", "initials": "V", "orcid": "0000-0002-8140-8010", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a2fcaf4f76849ffb23f71e1289381df.json"}}, {"family": "Andersson", "given": "P", "initials": "P", "orcid": "0000-0001-9807-446X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87b95f3d1c8a4aecaa0a7ebfa9e6d0a6.json"}}, {"family": "Landis", "given": "B N", "initials": "BN", "orcid": "0000-0001-6034-3724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14b3e598649c40998778371286527b8c.json"}}, {"family": "Becker", "given": "M", "initials": "M", "orcid": "0000-0001-9644-9053", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00c51cc049aa40799398a72230f16c0d.json"}}, {"family": "Lundstr\u00f6m", "given": "J N", "initials": "JN", "orcid": "0000-0002-3529-8981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a92f50aea024a1fbf0cfda979efef11.json"}}], "type": "journal-article", "published": "2022-11-24", "journal": {"title": "AJNR Am J Neuroradiol", "issn": "0195-6108", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.3174/ajnr.a7713", "pmid": "36423956", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:42:39.664Z", "modified": "2022-11-25T07:11:04.729Z"}, {"entity": "publication", "iuid": "7ab0920969114ec5909c80f2bd372253", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7ab0920969114ec5909c80f2bd372253.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7ab0920969114ec5909c80f2bd372253"}}, "title": "Corrigendum: Vaccine safety surveillance using routinely collected healthcare data-An empirical evaluation of epidemiological designs.", "authors": [{"family": "Schuemie", "given": "Martijn J", "initials": "MJ"}, {"family": "Arshad", "given": "Faaizah", "initials": "F"}, {"family": "Pratt", "given": "Nicole", "initials": "N"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Lai", "given": "Lana Y H", "initials": "LYH"}, {"family": "Li", "given": "Xintong", "initials": "X"}, {"family": "Fortin", "given": "Stephen", "initials": "S"}, {"family": "Minty", "given": "Evan", "initials": "E"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}], "type": "published erratum", "published": "2022-11-24", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "13", "pages": "1088973", "issn-l": "1663-9812"}, "abstract": "[This corrects the article DOI: 10.3389/fphar.2022.893484.].", "doi": "10.3389/fphar.2022.1088973", "pmid": "36506524", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9731373"}, {"db": "pii", "key": "1088973"}], "notes": [], "created": "2023-01-13T10:01:41.744Z", "modified": "2023-01-13T10:01:41.747Z"}, {"entity": "publication", "iuid": "0e008e3a54a5489dbbdbe804147970ba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e008e3a54a5489dbbdbe804147970ba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e008e3a54a5489dbbdbe804147970ba"}}, "title": "Why women choose self-managed telemedicine abortion in the Netherlands during the COVID-19 pandemic: a national mixed methods study.", "authors": [{"family": "Cui", "given": "Nanke", "initials": "N", "orcid": "0000-0001-6780-7106", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b76f8edda00f4355bb31d820f7183366.json"}}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}, {"family": "Gomperts", "given": "Rebecca", "initials": "R"}], "type": "journal article", "published": "2022-11-21", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-2009", "issn-l": "2515-1991"}, "abstract": "The COVID-19 pandemic has imposed strict lockdown restrictions that have introduced barriers to in-person abortion clinic visits in the Netherlands. Women on Web (WoW) is a global medical abortion telemedicine service operating outside the formal health sector.\n\nTo understand the motivations and perceived barriers women faced when choosing telemedicine abortion outside the formal health sector, and how this was affected by the pandemic.\n\n178 women who completed an online consultation on the Dutch WoW website during the period 6 March 2020 to 5 March 2021 were included in this cross-sectional cohort study and exploratory qualitative study. Patient characteristics and motivations were analysed and associated with the severity of COVID-19 restrictions. Email exchanges in which women could further describe their requests were also examined for recurrent clarification of motivations.\n\nWomen experienced barriers to regular abortion care due to COVID-19 restrictions and had the preference to (1) self-manage their abortion, (2) stay in the comfort of their own home, and (3) keep their abortion private. In particular, women who did not live in the cities where abortion clinics were located experienced barriers to abortion services. As COVID-19 restrictions tightened, it was more frequently mentioned that women sought help from WoW because COVID-19 restrictions and abortion care were not accessible to them in the Netherlands. In the qualitative analysis of email exchanges, the reasons of COVID-19, privacy concerns, and domestic violence were particularly evident.\n\nIn the Netherlands, barriers to receiving adequate abortion care were exacerbated for women in vulnerable positions such as being geographically farther away from an abortion clinic, being in a deprived socioeconomic position, or being in an unsafe home situation. Similar to other medical care, abortion care should be deliverable online.", "doi": "10.1136/bmjsrh-2022-201591", "pmid": "36410763", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjsrh-2022-201591"}], "notes": [], "created": "2022-11-22T10:00:11.822Z", "modified": "2022-11-22T10:00:28.944Z"}, {"entity": "publication", "iuid": "7b8c22670a484cbdac5ca3ae2436fe17", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b8c22670a484cbdac5ca3ae2436fe17.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b8c22670a484cbdac5ca3ae2436fe17"}}, "title": "Human cytomegalovirus infection of epithelial cells increases SARS-CoV-2 superinfection by upregulating the ACE2 receptor.", "authors": [{"family": "Perera", "given": "Marianne R", "initials": "MR", "orcid": "0000-0001-9175-0568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/455783d64b804bb18b75d77628a63d82.json"}}, {"family": "Greenwood", "given": "Edward Jd", "initials": "EJ"}, {"family": "Crozier", "given": "Thomas Wm", "initials": "TW"}, {"family": "Elder", "given": "Elizabeth G", "initials": "EG"}, {"family": "Schmitt", "given": "Janika", "initials": "J"}, {"family": "Crump", "given": "Colin M", "initials": "CM"}, {"family": "Lehner", "given": "Paul J", "initials": "PJ"}, {"family": "Wills", "given": "Mark R", "initials": "MR"}, {"family": "Sinclair", "given": "John H", "initials": "JH"}], "type": "journal article", "published": "2022-11-21", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899"}, "abstract": "SARS-CoV-2, the causative agent of COVID-19, has caused widespread morbidity and mortality since its onset in late 2019. Here, we demonstrate that prior infection with human cytomegalovirus (HCMV) substantially increases infection with SARS-CoV-2 in vitro. HCMV is a common herpesvirus carried by 40-100% of the population which can reactivate in the lung under inflammatory conditions, such as those resulting from SARS-CoV-2 infection. We show in both endothelial and epithelial cell types that HCMV infection upregulates ACE2, the SARS-CoV-2 cell entry receptor. These observations suggest that HCMV reactivation events in the lung of healthy HCMV carriers could exacerbate SARS-CoV-2 infection and subsequent COVID-19 symptoms. This effect could contribute to the disparity of disease severity seen in ethnic minorities and those with lower socio-economic status, due to their higher CMV seroprevalence. Our results warrant further clinical investigation as to whether HCMV infection influences the pathogenesis of SARS-CoV-2.", "doi": "10.1093/infdis/jiac452", "pmid": "36408607", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6835053"}], "notes": [], "created": "2022-11-22T10:02:17.593Z", "modified": "2022-11-22T10:02:17.628Z"}, {"entity": "publication", "iuid": "84ce80a5ceb44e6ea8458c999fea427b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84ce80a5ceb44e6ea8458c999fea427b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84ce80a5ceb44e6ea8458c999fea427b"}}, "title": "Detection of SARS-CoV-2 antibodies in serum and dried blood spot samples of vaccinated individuals using a sensitive homogeneous proximity extension assay.", "authors": [{"family": "Zhao", "given": "Hongxing", "initials": "H"}, {"family": "Wang", "given": "Mengqi", "initials": "M"}, {"family": "Muthelo", "given": "Phathutshedzo", "initials": "P"}, {"family": "L\u00f6f", "given": "Liza", "initials": "L"}, {"family": "Sterky", "given": "Fredrik", "initials": "F"}, {"family": "Gallini", "given": "Radiosa", "initials": "R"}, {"family": "Kumar", "given": "Nallani Vijay", "initials": "NV"}, {"family": "Monsen", "given": "Tor", "initials": "T"}, {"family": "Nilsson", "given": "Kenneth", "initials": "K"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Kamali-Moghaddam", "given": "Masood", "initials": "M"}, {"family": "Mei", "given": "Ya-Fang", "initials": "YF"}, {"family": "Landegren", "given": "Ulf", "initials": "U"}], "type": "journal article", "published": "2022-11-21", "journal": {"title": "N Biotechnol", "issn": "1876-4347", "issn-l": null}, "abstract": "A homogeneous PCR-based assay for sensitive and specific detection of antibodies in serum or dried blood spots (DBS) is presented and the method is used to monitor individuals infected with or vaccinated against SARS-CoV-2. Detection probes were prepared by conjugating the recombinant spike protein subunit 1 (S1), containing the receptor binding domain (RBD) of SARS-CoV-2, to each of a pair of specific oligonucleotides. The same was done for the nucleocapsid protein (NP). Upon incubation with serum or DBS samples, the bi- or multivalency of the antibodies (IgG, IgA or IgM) brings pairs of viral proteins with their conjugated oligonucleotides in proximity and can be detected by a modified proximity extension assay (PEA). Anti-S1 and anti-NP antibodies could be detected simultaneously from one incubation reaction. This Antibody PEA (AbPEA) test uses only 1\u00b5l of neat or up to 100,000-fold diluted serum or one \u00f81.2mm disc cut from a DBS. All 100 investigated sera and 21 DBS collected prior to the COVID-19 outbreak were negative, demonstrating a 100% specificity. The area under the curve, as evaluated by the Receiver Operating Characteristic (ROC) analysis reached 0.998 (95%CI: 0.993-1) for samples taken from 11 days after symptoms onset. The kinetics of antibody responses were monitored after a first and second vaccination using serially collected DBS from 14 individuals. AbPEA offers highly specific and sensitive solution-phase antibody detection without requirement for secondary antibodies, no elution step when using DBS sample and a simple procedure that lends itself to multiplex survey of antibody responses.", "doi": "10.1016/j.nbt.2022.11.004", "pmid": "36423830", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1871-6784(22)00063-2"}], "notes": [], "created": "2022-11-25T07:12:23.583Z", "modified": "2022-11-25T07:12:47.576Z"}, {"entity": "publication", "iuid": "d576447f4dd14b6dae0e0cb5e7ea381e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d576447f4dd14b6dae0e0cb5e7ea381e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d576447f4dd14b6dae0e0cb5e7ea381e"}}, "title": "A comprehensive characterisation of patients diagnosed with post-COVID-19 condition in Sweden 16 months after the introduction of the ICD-10 diagnosis code (U09.9): a population-based cohort study.", "authors": [{"family": "Bygdell", "given": "Maria", "initials": "M"}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Lundberg", "given": "Lisa", "initials": "L"}, {"family": "Gyll", "given": "David", "initials": "D"}, {"family": "Martikainen", "given": "Jari", "initials": "J"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2022-11-18", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": null, "issue": null, "pages": null}, "abstract": "The objective of this study was to provide a comprehensive characterisation of patients diagnosed with post-COVID-19 condition (PCC) during the first 16 months of usage of the International Classification of Diseases revision 10 (ICD-10) diagnosis code U09.9 in Sweden.\n\nWe used data from national registers and primary healthcare databases for all adult inhabitants of the two largest regions in Sweden, comprising 4.1 million inhabitants (approximately 40% of the Swedish population). We present the cumulative incidence and incidence rate of PCC overall and among subgroups and describe COVID-19 patients with or without PCC regarding sociodemographic characteristics, comorbidities, subsequent diseases, COVID-19 severity, and virus variants.\n\nOf all registered COVID-19 cases available for PCC diagnosis (n=506,107), 2.0% (n=10,196) had been diagnosed with PCC using ICD-10 code U09.9 as of 15 February 2022 in the two largest regions in Sweden. The cumulative incidence was higher among women compared to men (2.3% vs 1.6%, p<0.001). The majority of PCC cases (n=7,162, 70.2%) had not been hospitalised for COVID-19. This group was more commonly female (69.9% vs 52.9%, p<0.001), had a tertiary education (51.0% vs 44.1%, p<0.001), and was older (median age difference 5.7 years, p<0.001) compared to non-hospitalised COVID-19 patients without PCC.\n\nThis characterisation furthers the understanding of patients diagnosed with PCC and could support policymakers with appropriate societal and healthcare resource allocation.", "doi": "10.1016/j.ijid.2022.11.021", "pmid": "36410693", "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Research Area: Call 1": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(22)00612-9"}], "notes": [], "created": "2022-11-22T10:01:50.032Z", "modified": "2022-11-25T07:21:32.562Z"}, {"entity": "publication", "iuid": "302309021a0f49308e65147d54053a8e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/302309021a0f49308e65147d54053a8e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/302309021a0f49308e65147d54053a8e"}}, "title": "Self-reported symptom severity, general health, and impairment in post-acute phases of COVID-19: retrospective cohort study of Swedish public employees.", "authors": [{"family": "Larsson", "given": "Simon B", "initials": "SB"}, {"family": "von Feilitzen", "given": "Gustaf Stuk\u00e1t", "initials": "GS"}, {"family": "Andersson", "given": "Maria E", "initials": "ME"}, {"family": "Sikora", "given": "Per", "initials": "P"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Nord\u00e9n", "given": "Rickard", "initials": "R"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Sigstr\u00f6m", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2022-11-17", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "19818", "issn-l": "2045-2322"}, "abstract": "This study aimed to examine current symptom severity and general health in a sample of primarily non-hospitalized persons with polymerase chain reaction (PCR) confirmed COVID-19 in comparison to PCR negative controls. During the first quarter of 2021, we conducted an online survey among public employees in West Sweden, with a valid COVID-19 test result. The survey assessed past-month severity of 28 symptoms and signs, self-rated health, the WHO Disability Assessment Schedule (WHODAS) 2.0 and illness severity at the time of test. We linked participants' responses to their SARS-CoV-2 PCR tests results. We compared COVID-19 positive and negative participants using univariable and multivariable regression analyses. Out of 56,221 invited, 14,222 (25.3%) responded, with a response rate of 50% among SARS-CoV-2 positive individuals. Analysis included 10,194 participants (86.4% women, mean age 45 years) who tested positive 4-12 weeks (N = 1425; subacute) and > 12 weeks (N = 1584; postcovid) prior to the survey, and 7185 PCR negative participants who did not believe that they had had COVID-19. Symptoms were highly prevalent in all groups, with worst symptoms in subacute phase participants, followed by postcovid phase and PCR negative participants. The most specific symptom for COVID-19 was loss of smell or taste. Both WHODAS 2.0 score and self-rated health were worst in subacute participants, and modestly worse in postcovid participants than in negative controls. Female gender, older age and acute illness severity had larger effects on self-rated health and WHODAS 2.0 score in PCR positive participants than in PCR negative. Studies with longer follow-up are needed to determine the long-term improvement after COVID-19.", "doi": "10.1038/s41598-022-24307-1", "pmid": "36396860", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9672032"}, {"db": "pii", "key": "10.1038/s41598-022-24307-1"}], "notes": [], "created": "2022-11-25T07:23:08.875Z", "modified": "2022-11-25T07:23:08.878Z"}, {"entity": "publication", "iuid": "bb8633cac6b742179bc3ea753f065938", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb8633cac6b742179bc3ea753f065938.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb8633cac6b742179bc3ea753f065938"}}, "title": "A population-based, retrospective cohort study of the association between ABO blood group and risk of COVID-19.", "authors": [{"family": "Dahl\u00e9n", "given": "Torsten", "initials": "T", "orcid": "0000-0002-3856-7227", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69a3a4703c134438836a76bd0dec1c68.json"}}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Edgren", "given": "Gustaf", "initials": "G", "orcid": "0000-0002-2198-4745", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8202fb97787474d931b94103878cf32.json"}}], "type": "journal article", "published": "2022-11-13", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null}, "abstract": "Several studies have investigated associations between ABO blood group and risk of COVID-19, with inconsistent results.\n\nTo study associations between ABO blood group and risk of different stages of COVID-19.\n\nThe study was based on nationwide registers encompassing all blood-grouped persons in Sweden, and all of their COVID-19 related outcomes. Associations between ABO blood group and COVID-19 outcomes were estimated using Poisson regression models. Analyses were conducted overall and stratified by vaccination status.\n\nA total of 4,986,878 individuals were included. The incidence rate ratios (IRRs), of testing positive for COVID-19 were 1.08 (95% confidence interval [CI], 1.07-1.08), 1.06 (95% CI, 1.05-1.07), and 1.01 (95% CI, 1.00-1.01) for blood groups A, AB, and B, as compared to O, respectively. Similar associations were seen for risk of hospital admissions, ICU admissions, and risk of death. For most outcomes, associations with ABO blood group were much attenuated or even reversed in vaccinated individuals.\n\nIndividuals with blood groups A, AB, and B are at increased risk of contracting COVID-19 as well as developing more severe forms of the disease. This article is protected by copyright. All rights reserved.", "doi": "10.1111/joim.13588", "pmid": "36372955", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-11-25T10:44:16.941Z", "modified": "2022-11-25T10:44:17.014Z"}, {"entity": "publication", "iuid": "48d95388505149eaa1f7304347c87a05", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/48d95388505149eaa1f7304347c87a05.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/48d95388505149eaa1f7304347c87a05"}}, "title": "Long-term SARS-CoV-2 surveillance in the wastewater of Stockholm: What lessons can be learned from the Swedish perspective?", "authors": [{"family": "Perez-Zabaleta", "given": "Mariel", "initials": "M"}, {"family": "Archer", "given": "Amena", "initials": "A"}, {"family": "Khatami", "given": "Kasra", "initials": "K"}, {"family": "Jafferali", "given": "Mohammed Hakim", "initials": "MH"}, {"family": "Nandy", "given": "Prachi", "initials": "P"}, {"family": "Atasoy", "given": "Merve", "initials": "M"}, {"family": "Birgersson", "given": "Madeleine", "initials": "M"}, {"family": "Williams", "given": "Cecilia", "initials": "C"}, {"family": "Cetecioglu", "given": "Zeynep", "initials": "Z"}], "type": "journal article", "published": "2022-11-08", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "volume": "858", "issue": "Pt 3", "pages": "160023", "issn-l": "0048-9697"}, "abstract": "Wastewater-based epidemiology (WBE) can be used to track the spread of SARS-CoV-2 in a population. This study presents the learning outcomes from over two-year long monitoring of SARS-CoV-2 in Stockholm, Sweden. The three main wastewater treatment plants in Stockholm, with a total of six inlets, were monitored from April 2020 until June 2022 (in total 600 samples). This spans five major SARS-CoV-2 waves, where WBE data provided early warning signals for each wave. Further, the measured SARS-CoV-2 content in the wastewater correlated significantly with the level of positive COVID-19 tests (r = 0.86; p << 0.0001) measured by widespread testing of the population. Moreover, as a proof-of-concept, six SARS-CoV-2 variants of concern were monitored using hpPCR assay, demonstrating that variants can be traced through wastewater monitoring. During this long-term surveillance, two sampling protocols, two RNA concentration/extraction methods, two calculation approaches, and normalization to the RNA virus Pepper mild mottle virus (PMMoV) were evaluated. In addition, a study of storage conditions was performed, demonstrating that the decay of viral RNA was significantly reduced upon the addition of glycerol to the wastewater before storage at -80 \u00b0C. Our results provide valuable information that can facilitate the incorporation of WBE as a prediction tool for possible future outbreaks of SARS-CoV-2 and preparations for future pandemics.", "doi": "10.1016/j.scitotenv.2022.160023", "pmid": "36356735", "labels": {"Category: Other": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Research Area: Environmental virus profiling": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9640212"}, {"db": "pii", "key": "S0048-9697(22)07123-6"}], "notes": [], "created": "2022-11-25T10:50:01.947Z", "modified": "2022-11-25T10:50:01.951Z"}, {"entity": "publication", "iuid": "acbce148a528462aab930c001ed75746", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/acbce148a528462aab930c001ed75746.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/acbce148a528462aab930c001ed75746"}}, "title": "Innate immune mechanisms of mRNA vaccines.", "authors": [{"family": "Verbeke", "given": "Rein", "initials": "R"}, {"family": "Hogan", "given": "Michael J", "initials": "MJ"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "Pardi", "given": "Norbert", "initials": "N"}], "type": "journal article", "published": "2022-11-08", "journal": {"title": "Immunity", "issn": "1074-7613", "volume": "55", "issue": "11", "pages": "1993-2005", "issn-l": null}, "abstract": "The lipid nanoparticle (LNP)-encapsulated, nucleoside-modified mRNA platform has been used to generate safe and effective vaccines in record time against COVID-19. Here, we review the current understanding of the manner whereby mRNA vaccines induce innate immune activation and how this contributes to protective immunity. We discuss innate immune sensing of mRNA vaccines at the cellular and intracellular levels and consider the contribution of both the mRNA and the LNP components to their immunogenicity. A key message that is emerging from recent observations is that the LNP carrier acts as a powerful adjuvant for this novel vaccine platform. In this context, we highlight important gaps in understanding and discuss how new insight into the mechanisms underlying the effectiveness of mRNA-LNP vaccines may enable tailoring mRNA and carrier molecules to develop vaccines with greater effectiveness and milder adverse events in the future.", "doi": "10.1016/j.immuni.2022.10.014", "pmid": "36351374", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC9641982"}, {"db": "pii", "key": "S1074-7613(22)00555-6"}], "notes": [], "created": "2022-11-25T10:51:09.699Z", "modified": "2022-11-25T10:51:09.708Z"}, {"entity": "publication", "iuid": "4bf9511a136b46edaede7c1cedfd44a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4bf9511a136b46edaede7c1cedfd44a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4bf9511a136b46edaede7c1cedfd44a4"}}, "title": "Size distribution of exhaled aerosol particles containing SARS-CoV-2 RNA.", "authors": [{"family": "Alsved", "given": "Malin", "initials": "M", "orcid": "0000-0002-8407-8758", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f599d60401c1483a9422fbb048c6d050.json"}}, {"family": "Nygren", "given": "David", "initials": "D", "orcid": "0000-0003-2426-7204", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d84ae6e240ec4a3caaf519a43f9d7cf9.json"}}, {"family": "Thuresson", "given": "Sara", "initials": "S", "orcid": "0000-0001-8243-3632", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21b29967898c42dd87cd587d662500d5.json"}}, {"family": "Fraenkel", "given": "Carl-Johan", "initials": "CJ", "orcid": "0000-0002-3086-5553", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6aec05367593436baef9decc3616e9c9.json"}}, {"family": "Medstrand", "given": "Patrik", "initials": "P", "orcid": "0000-0003-4259-8744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/558185ff31d94cacb1931015f2e12be4.json"}}, {"family": "L\u00f6ndahl", "given": "Jakob", "initials": "J", "orcid": "0000-0001-9379-592X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7648041474a8469aa54218ca177e4c19.json"}}], "type": "journal article", "published": "2022-11-04", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "pages": "1-6", "issn-l": "2374-4235"}, "abstract": "SARS-CoV-2 in exhaled aerosols is considered an important contributor to the spread of COVID-19. However, characterizing the size distribution of virus-containing aerosol particles has been challenging as high concentrations of SARS-CoV-2 in exhaled air is mainly present close to symptom onset. We present a case study of a person with COVID-19 who was able to participate in extensive measurements of exhaled aerosols already on the day of symptom onset and then for the following three days.\n\nAerosol collection was performed using an eight-stage impactor while the subject was breathing, talking and singing, for 30 min each, once every day. In addition, nasopharyngeal samples, saliva samples, room air samples and information on symptom manifestations were collected every day. Samples were analyzed by RT-qPCR for detection of SARS-CoV-2 RNA.\n\nSARS-CoV-2 RNA was detected in seven of the eight particle size fractions, from 0.34 to >8.1 \u00b5m, with the highest concentrations found in 0.94-2.8 \u00b5m particles. The concentration of SARS-CoV-2 RNA was highest on the day of symptom onset, and declined for each day thereafter.\n\nOur data showed that 90% of the exhaled SARS-CoV-2 RNA was found in aerosol particles <4.5 \u00b5m, indicating the importance of small particles for the transmission of COVID-19 close to symptom onset. These results are important for our understanding of airborne transmission, for developing accurate models and for selecting appropriate mitigation strategies.", "doi": "10.1080/23744235.2022.2140822", "pmid": "36331347", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Funder: Forte": null, "Type: Journal article": null, "Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-11-25T10:53:30.989Z", "modified": "2022-11-25T10:53:45.902Z"}, {"entity": "publication", "iuid": "9b06a05223c148d0b2e540a049dd360d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b06a05223c148d0b2e540a049dd360d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b06a05223c148d0b2e540a049dd360d"}}, "title": "An intersectional analysis of sociodemographic disparities in Covid-19 vaccination: A nationwide register-based study in Sweden.", "authors": [{"family": "Spetz", "given": "M", "initials": "M"}, {"family": "Lundberg", "given": "L", "initials": "L"}, {"family": "Nwaru", "given": "C", "initials": "C"}, {"family": "Li", "given": "H", "initials": "H"}, {"family": "Santosa", "given": "A", "initials": "A"}, {"family": "Ng", "given": "N", "initials": "N"}, {"family": "Leach", "given": "S", "initials": "S"}, {"family": "Gissl\u00e9n", "given": "M", "initials": "M"}, {"family": "Hammar", "given": "N", "initials": "N"}, {"family": "Nyberg", "given": "F", "initials": "F"}, {"family": "Rosvall", "given": "M", "initials": "M"}], "type": "journal article", "published": "2022-11-02", "journal": {"title": "Vaccine", "issn": "1873-2518", "volume": "40", "issue": "46", "pages": "6640-6648", "issn-l": null}, "abstract": "Studies on sociodemographic disparities in Covid-19 vaccination uptake in the general population are still limited and mostly focused on older adults. This study examined sociodemographic differences in Covid-19 vaccination uptake in the total Swedish population aged 18-64 years.\n\nNational Swedish register data within the SCIFI-PEARL project were used to cross-sectionally investigate sociodemographic differences in Covid-19 vaccination among Swedish adults aged 18-64 years (n = 5,987,189) by 12 October 2021. Using logistic regression models, analyses were adjusted for sociodemographic factors, region of residence, history of Covid-19, and comorbidities. An intersectional analysis approach including several cross-classified subgroups was used to further address the complexity of sociodemographic disparities in vaccination uptake.\n\nBy 12 October 2021, 76\u00b70% of the Swedish population 18-64 years old had received at least two doses of Covid-19 vaccine, an additional 5\u00b75% had received only one dose, and 18\u00b75% were non-vaccinated. Non-vaccinated individuals were, compared to vaccinated, more often younger, male, had a lower income, were not gainfully employed, and/or were born outside Sweden. The social patterning for vaccine dose two was similar, but weaker, than for dose one. After multivariable adjustments, findings remained but were attenuated indicating the need to consider different sociodemographic factors simultaneously. The intersectional analysis showed a large variation in vaccine uptake ranging from 32% to 96% in cross-classified subgroups, reflecting considerable sociodemographic heterogeneity in vaccination coverage.\n\nOur study, addressing the entire Swedish population aged 18-64 years, showed broad sociodemographic disparities in Covid-19 vaccine uptake but also wide heterogeneities in coverage. The intersectional analysis approach indicates that focusing on specific sociodemographic factors in isolation and group average risks without considering the heterogeneity within such groups will risk missing the full variability of vaccine coverage.\n\nSciLifeLab / Knut & Alice Wallenberg Foundation, Swedish Research Council, Swedish government ALF agreement, FORMAS.", "doi": "10.1016/j.vaccine.2022.09.065", "pmid": "36210254", "labels": {"Research Area: Vaccine": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Public Health": null, "Category: Health": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC9515344"}, {"db": "pii", "key": "S0264-410X(22)01186-0"}], "notes": [], "created": "2022-11-29T14:27:27.622Z", "modified": "2022-11-29T14:27:27.626Z"}, {"entity": "publication", "iuid": "c3ab49fa7c1c4adeae09264231eff500", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3ab49fa7c1c4adeae09264231eff500.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3ab49fa7c1c4adeae09264231eff500"}}, "title": "Updated Results of the COVID-19 in MS Global Data Sharing Initiative: Anti-CD20 and Other Risk Factors Associated With COVID-19 Severity.", "authors": [{"family": "Simpson-Yap", "given": "Steve", "initials": "S"}, {"family": "Pirmani", "given": "Ashkan", "initials": "A"}, {"family": "Kalincik", "given": "Tomas", "initials": "T"}, {"family": "De Brouwer", "given": "Edward", "initials": "E"}, {"family": "Geys", "given": "Lotte", "initials": "L"}, {"family": "Parciak", "given": "Tina", "initials": "T"}, {"family": "Helme", "given": "Anne", "initials": "A"}, {"family": "Rijke", "given": "Nick", "initials": "N"}, {"family": "Hillert", "given": "Jan A", "initials": "JA"}, {"family": "Moreau", "given": "Yves", "initials": "Y"}, {"family": "Edan", "given": "Gilles", "initials": "G"}, {"family": "Sharmin", "given": "Sifat", "initials": "S"}, {"family": "Spelman", "given": "Tim", "initials": "T"}, {"family": "McBurney", "given": "Robert", "initials": "R"}, {"family": "Schmidt", "given": "Hollie", "initials": "H"}, {"family": "Bergmann", "given": "Arnfin B", "initials": "AB"}, {"family": "Braune", "given": "Stefan", "initials": "S"}, {"family": "Stahmann", "given": "Alexander", "initials": "A"}, {"family": "Middleton", "given": "Rod M", "initials": "RM"}, {"family": "Salter", "given": "Amber", "initials": "A"}, {"family": "Bebo", "given": "Bruce", "initials": "B"}, {"family": "Van der Walt", "given": "Anneke", "initials": "A"}, {"family": "Butzkueven", "given": "Helmut", "initials": "H"}, {"family": "Ozakbas", "given": "Serkan", "initials": "S"}, {"family": "Boz", "given": "Cavit", "initials": "C"}, {"family": "Karabudak", "given": "Rana", "initials": "R"}, {"family": "Alroughani", "given": "Raed", "initials": "R"}, {"family": "Rojas", "given": "Juan I", "initials": "JI"}, {"family": "van der Mei", "given": "Ingrid A", "initials": "IA"}, {"family": "Sciascia do Olival", "given": "Guilherme", "initials": "G"}, {"family": "Magyari", "given": "Melinda", "initials": "M"}, {"family": "Alonso", "given": "Ricardo N", "initials": "RN"}, {"family": "Nicholas", "given": "Richard S", "initials": "RS"}, {"family": "Chertcoff", "given": "Anibal S", "initials": "AS"}, {"family": "de Torres", "given": "Ana Zabalza", "initials": "AZ"}, {"family": "Arrambide", "given": "Georgina", "initials": "G"}, {"family": "Nag", "given": "Nupur", "initials": "N"}, {"family": "Descamps", "given": "Annabel", "initials": "A"}, {"family": "Costers", "given": "Lars", "initials": "L"}, {"family": "Dobson", "given": "Ruth", "initials": "R"}, {"family": "Miller", "given": "Aleisha", "initials": "A"}, {"family": "Rodrigues", "given": "Paulo", "initials": "P"}, {"family": "Pr\u010dkovska", "given": "Vesna", "initials": "V"}, {"family": "Comi", "given": "Giancarlo", "initials": "G"}, {"family": "Peeters", "given": "Liesbet M", "initials": "LM"}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "Neurol Neuroimmunol Neuroinflamm", "issn": "2332-7812", "volume": "9", "issue": "6", "pages": "e200021", "issn-l": null}, "abstract": "Certain demographic and clinical characteristics, including the use of some disease-modifying therapies (DMTs), are associated with severe acute respiratory syndrome coronavirus 2 infection severity in people with multiple sclerosis (MS). Comprehensive exploration of these relationships in large international samples is needed.\n\nClinician-reported demographic/clinical data from 27 countries were aggregated into a data set of 5,648 patients with suspected/confirmed coronavirus disease 2019 (COVID-19). COVID-19 severity outcomes (hospitalization, admission to intensive care unit [ICU], requiring artificial ventilation, and death) were assessed using multilevel mixed-effects ordered probit and logistic regression, adjusted for age, sex, disability, and MS phenotype. DMTs were individually compared with glatiramer acetate, and anti-CD20 DMTs with pooled other DMTs and with natalizumab.\n\nOf 5,648 patients, 922 (16.6%) with suspected and 4,646 (83.4%) with confirmed COVID-19 were included. Male sex, older age, progressive MS, and higher disability were associated with more severe COVID-19. Compared with glatiramer acetate, ocrelizumab and rituximab were associated with higher probabilities of hospitalization (4% [95% CI 1-7] and 7% [95% CI 4-11]), ICU/artificial ventilation (2% [95% CI 0-4] and 4% [95% CI 2-6]), and death (1% [95% CI 0-2] and 2% [95% CI 1-4]) (predicted marginal effects). Untreated patients had 5% (95% CI 2-8), 3% (95% CI 1-5), and 1% (95% CI 0-3) higher probabilities of the 3 respective levels of COVID-19 severity than glatiramer acetate. Compared with pooled other DMTs and with natalizumab, the associations of ocrelizumab and rituximab with COVID-19 severity were also more pronounced. All associations persisted/enhanced on restriction to confirmed COVID-19.\n\nAnalyzing the largest international real-world data set of people with MS with suspected/confirmed COVID-19 confirms that the use of anti-CD20 medication (both ocrelizumab and rituximab), as well as male sex, older age, progressive MS, and higher disability are associated with more severe course of COVID-19.", "doi": "10.1212/NXI.0000000000200021", "pmid": "36038263", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9423711"}, {"db": "pii", "key": "9/6/e200021"}], "notes": [], "created": "2022-10-07T12:45:50.749Z", "modified": "2023-06-19T14:41:09.696Z"}, {"entity": "publication", "iuid": "863172b33d8c41d79b4bd9b33c12cb9a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/863172b33d8c41d79b4bd9b33c12cb9a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/863172b33d8c41d79b4bd9b33c12cb9a"}}, "title": "The association between pre-exposure to glucocorticoids and other immunosuppressant drugs with severe COVID-19 outcomes.", "authors": [{"family": "Brodin", "given": "Rakel", "initials": "R"}, {"family": "van der Werff", "given": "Suzannes Desir\u00e9e", "initials": "SD"}, {"family": "Hedberg", "given": "Pontus", "initials": "P"}, {"family": "F\u00e4rnert", "given": "Anna", "initials": "A"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Requena-M\u00e9ndez", "given": "Ana", "initials": "A"}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "Clin Microbiol Infect", "issn": "1469-0691", "volume": "28", "issue": "11", "pages": "1477-1485", "issn-l": null}, "abstract": "Whether preinfection use of immunosuppressant drugs is associated with COVID-19 severity remains unclear. The study was aimed to determine the association between preinfection use of immunosuppressant drugs with COVID-19 outcomes within 1 month after COVID-19 diagnosis.\n\nThis cohort study included individuals aged \u226518 years with underlying conditions associated with an immunocompromised state and diagnosed with COVID-19 between February 2020 and January 2021 at Karolinska University Hospital, Stockholm. Exposure to immunosuppressant drugs was defined based on dose and duration of drugs (glucocorticoids and drugs included in L01 or L04 chapter of Anatomical Therapeutic Chemical classification) before COVID-19 diagnosis. Outcomes included hospital admission, ICU admission, mechanical ventilation, mortality, renal failure, stroke, pulmonary embolism, and cardiac event. ORs were calculated using logistic regression and baseline covariate adjustment for confounding with inverse probability of treatment weights.\n\nOf 1067 included individuals, 444 were pre-exposed to immunosuppressive treatments before COVID-19 diagnosis (72 high-dose glucocorticoids, 255 L01 drugs (antineoplastics), 198 L04 (other immunosuppressants) and 78 to multiple drugs). There was no association between pre-exposure and hospital admission (OR 0.83, 95% CI 0.64 to 1.09) because of COVID-19. Pre-exposure to L01 or L04 drugs were not associated with hospital admission (adjusted ORs (aORs): 1.23, 0.86 to 1.76 and 1.31, 0.77 to 2.21) or other outcomes. High-dose glucocorticoids (\u226520 mg/day prednisolone equivalent) were associated with hospital admission (aOR 2.50, 1.26 to 4.96), cardiac events (aOR 1.93, 1.08 to 3.46), pulmonary embolism (aOR 2.78, 1.08 to 7.15), and mortality (aOR 3.48, 1.77 to 6.86) due to COVID-19.\n\nAntineoplastic and other immunosuppressants drugs were not associated with COVID-19 severity whereas high-dose glucocorticoids were associated. Further studies should evaluate the effect of pre-exposure of different dose of glucocorticoids on COVID-19 prognosis.", "doi": "10.1016/j.cmi.2022.05.014", "pmid": "35644344", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(22)00270-1"}, {"db": "pmc", "key": "PMC9135501"}], "notes": [], "created": "2022-06-21T17:35:23.959Z", "modified": "2022-10-31T17:26:54.979Z"}, {"entity": "publication", "iuid": "e2ff0bac268343ce8899e4948cf73082", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2ff0bac268343ce8899e4948cf73082.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2ff0bac268343ce8899e4948cf73082"}}, "title": "Patients' perspectives on the effect of the COVID-19 pandemic on access to cancer care and social contacts in Sweden and the UK: a cross-sectional study.", "authors": [{"family": "Edlund", "given": "Karolina", "initials": "K", "orcid": "0000-0003-2349-0076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8004580e2964f19aa44dca6399e4f84.json"}}, {"family": "Dahlstr\u00f6m", "given": "Lisen Arnheim", "initials": "LA", "orcid": "0000-0003-3926-9616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f5cf51d7b8e49cebe5e3743cb7ae71a.json"}}, {"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM", "orcid": "0000-0002-3912-1171", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f69d74b370764e2e93f8c98eca79e064.json"}}, {"family": "van der Kop", "given": "Mia L", "initials": "ML", "orcid": "0000-0002-5590-6833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b5c278a602240feb8953d0c02c029a0.json"}}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "Support Care Cancer", "issn": "1433-7339", "volume": "30", "issue": "11", "pages": "9101-9108", "issn-l": null}, "abstract": "We aimed to determine whether there was a difference in access to cancer-related healthcare between people living in Sweden and the United Kingdom (UK) during the COVID-19 pandemic. We also describe how the pandemic affected social contact of patients undergoing treatment.\n\nThis cross-sectional study used survey data collected through the War on Cancer mobile phone application between September 5, 2020, and January 6, 2021. We included individuals with cancer diagnoses living in Sweden or the UK. The association between difficulty accessing cancer-related healthcare and country was examined using logistic regression. Frequencies were used to describe the effect of the pandemic on social contact.\n\nOf 491 individuals included in the study, 183 were living in the UK and 308 in Sweden. Living in the UK was associated with greater difficulty accessing cancer-related healthcare (n = 99/183, 54.1%) than living in Sweden (n = 100/308, 32.5%) (odds ratio 2.12, 95% CI 1.39-3.23, p < 0.001). The pandemic affected social contact for almost all patients (n = 218/238, 91.6%) undergoing treatment.\n\nThis study highlights the differential impact that the pandemic may have had on patients' access to cancer-related care in the UK and Sweden. In both countries, the pandemic overwhelmingly affected social contact of individuals undergoing cancer treatment. New ways must be found to improve access to cancer-related care and reduce social isolation for patients with cancer during a pandemic.", "doi": "10.1007/s00520-022-07298-7", "pmid": "35984510", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9388965"}, {"db": "pii", "key": "10.1007/s00520-022-07298-7"}], "notes": [], "created": "2022-09-12T18:46:25.822Z", "modified": "2023-01-13T14:44:07.641Z"}, {"entity": "publication", "iuid": "59c5bb6eb35c4aabab0136466bd3af1e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/59c5bb6eb35c4aabab0136466bd3af1e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/59c5bb6eb35c4aabab0136466bd3af1e"}}, "title": "IL-6 signalling biomarkers in hospitalised patients with moderate to severe SARS-CoV-2 infection in a single centre study in Sweden.", "authors": [{"family": "Ziegler", "given": "Louise", "initials": "L"}, {"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Gigante", "given": "Bruna", "initials": "B"}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "Cytokine", "issn": "1043-4666", "issn-l": null, "volume": "159", "issue": null, "pages": "156020"}, "abstract": "COVID-19 disease severity and need for intensive care has been associated with profound immune disturbances in which interleukin 6 (IL-6) is central. IL-6 signals through two pathways: classical IL-6 signalling with C-reactive protein (CRP) as a product is pivotal in the acute immune response against pathogens while IL-6 trans-signalling is involved in prolonged inflammation. We measured biomarkers of the IL-6 classical and trans-signalling pathways in patients with moderate or severe COVID-19 in the first wave of the COVID-19 pandemic.\r\n\r\nIn a longitudinal cohort study including patients admitted to Danderyd hospital, Stockholm, Sweden, with COVID-19 (n = 112), plasma IL-6 mirroring activity in both pathways, CRP as marker of classical signalling and the soluble IL-6 receptor (sIL-6R) and soluble glycoprotein 130 (sgp130) as markers of trans-signalling were analysed at baseline. Potential differences in biomarker levels between groups of moderate and severe COVID-19 defined by care level, level of respiratory support and one-month mortality was analysed, as was correlations between biomarkers. In addition, levels 4 months after hospital admission were compared to those at baseline.\r\n\r\nLevels of IL-6 and CRP were increased in severe COVID-19 whereas IL-6 trans-signalling markers (sIL-6R, sgp130) did not differ between the groups. CRP correlated positively with IL-6 in all patients while correlation with IL-6 could not be demonstrated for sIL-6R and sgp130 in either group. Levels of IL-6, CRP and sIL-6R were significantly decreased after 4 months whereas sgp130 levels increased.\r\n\r\nClassical signalling is the dominating IL-6 pathway in moderate-severe COVID-19.", "doi": "10.1016/j.cyto.2022.156020", "pmid": "36057230", "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "S1043-4666(22)00229-0"}, {"db": "pmc", "key": "PMC9420722"}], "notes": [], "created": "2022-10-13T13:23:08.582Z", "modified": "2022-10-13T14:37:36.652Z"}, {"entity": "publication", "iuid": "c52dd95381fc49d9a6ea4aab11fd7674", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c52dd95381fc49d9a6ea4aab11fd7674.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c52dd95381fc49d9a6ea4aab11fd7674"}}, "title": "Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative.", "authors": [{"family": "Butler-Laporte", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-5388-0396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/529dc69151d3463e8480b975d70fa759.json"}}, {"family": "Povysil", "given": "Gundula", "initials": "G", "orcid": "0000-0003-4625-5909", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/658ac11ede214c9383221afb2d0b5ab1.json"}}, {"family": "Kosmicki", "given": "Jack A", "initials": "JA", "orcid": "0000-0003-1252-6192", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d39c52fe05574c1e90ca5f7e2daa921f.json"}}, {"family": "Cirulli", "given": "Elizabeth T", "initials": "ET", "orcid": "0000-0001-7808-2809", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/da51a8befd454b03b5bf8c50ca1835dd.json"}}, {"family": "Drivas", "given": "Theodore", "initials": "T", "orcid": "0000-0002-8717-0111", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c6643db2e4b4f92abf8a6b53c0d746a.json"}}, {"family": "Furini", "given": "Simone", "initials": "S"}, {"family": "Saad", "given": "Chadi", "initials": "C", "orcid": "0000-0001-6963-9126", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5636bfebba7144e7b729051d07f873ca.json"}}, {"family": "Schmidt", "given": "Axel", "initials": "A"}, {"family": "Olszewski", "given": "Pawel", "initials": "P", "orcid": "0000-0003-1010-8843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89b5f8798556430b867d8fcc5c2afbc6.json"}}, {"family": "Korotko", "given": "Urszula", "initials": "U", "orcid": "0000-0002-1779-8368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37a3dcefa2ca465cb9f3682f76ab5b83.json"}}, {"family": "Quinodoz", "given": "Mathieu", "initials": "M", "orcid": "0000-0002-9841-4433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41616c1f1c294ef585b140d8ee01434d.json"}}, {"family": "\u00c7elik", "given": "Elifnaz", "initials": "E", "orcid": "0000-0002-0324-5228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/043ad752eb754eb29107ebaff6a347c3.json"}}, {"family": "Kundu", "given": "Kousik", "initials": "K", "orcid": "0000-0002-1019-8351", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/775583a7e98545f1a4c5d1b2a94252b6.json"}}, {"family": "Walter", "given": "Klaudia", "initials": "K", "orcid": "0000-0003-4448-0301", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6e8e60bb41e40b399e86ee055bababd.json"}}, {"family": "Jung", "given": "Junghyun", "initials": "J"}, {"family": "Stockwell", "given": "Amy D", "initials": "AD"}, {"family": "Sloofman", "given": "Laura G", "initials": "LG", "orcid": "0000-0001-7628-4378", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/853b4f1cc0b04ed29fa07edb075688bc.json"}}, {"family": "Jordan", "given": "Daniel M", "initials": "DM", "orcid": "0000-0002-5318-8225", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/431bea0f7dbd46b0a60752f575783309.json"}}, {"family": "Thompson", "given": "Ryan C", "initials": "RC", "orcid": "0000-0002-0450-8181", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/acb45eb3b27e4b9191ddacfb0089321f.json"}}, {"family": "Del Valle", "given": "Diane", "initials": "D", "orcid": "0000-0001-6983-5362", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e9483a880d04872a10d52d4eb928e65.json"}}, {"family": "Simons", "given": "Nicole", "initials": "N", "orcid": "0000-0002-3952-1458", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a55f0ff0effc4d02b5ccb0a056b89936.json"}}, {"family": "Cheng", "given": "Esther", "initials": "E"}, {"family": "Sebra", "given": "Robert", "initials": "R"}, {"family": "Schadt", "given": "Eric E", "initials": "EE"}, {"family": "Kim-Schulze", "given": "Seunghee", "initials": "S"}, {"family": "Gnjatic", "given": "Sacha", "initials": "S"}, {"family": "Merad", "given": "Miriam", "initials": "M"}, {"family": "Buxbaum", "given": "Joseph D", "initials": "JD"}, {"family": "Beckmann", "given": "Noam D", "initials": "ND"}, {"family": "Charney", "given": "Alexander W", "initials": "AW"}, {"family": "Przychodzen", "given": "Bartlomiej", "initials": "B"}, {"family": "Chang", "given": "Timothy", "initials": "T", "orcid": "0000-0002-9225-9874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3bbf7182b1949eaaa49a64ca6b1946d.json"}}, {"family": "Pottinger", "given": "Tess D", "initials": "TD"}, {"family": "Shang", "given": "Ning", "initials": "N"}, {"family": "Brand", "given": "Fabian", "initials": "F", "orcid": "0000-0003-1885-7021", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3746b2b297d1475fbf6f40c0a0956bc6.json"}}, {"family": "Fava", "given": "Francesca", "initials": "F"}, {"family": "Mari", "given": "Francesca", "initials": "F"}, {"family": "Chwialkowska", "given": "Karolina", "initials": "K", "orcid": "0000-0001-8053-8959", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c03b0ca07f474484b9c6688e09ad9a1c.json"}}, {"family": "Niemira", "given": "Magdalena", "initials": "M", "orcid": "0000-0002-0701-4961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d67e7303fb3745a0bf8c606095670008.json"}}, {"family": "Pula", "given": "Szymon", "initials": "S", "orcid": "0000-0002-5684-5358", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5922e06d10574062ae4f2a8bea7ac407.json"}}, {"family": "Baillie", "given": "J Kenneth", "initials": "JK"}, {"family": "Stuckey", "given": "Alex", "initials": "A", "orcid": "0000-0001-8636-737X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f4f17b92dec479b8aa367a6e42cbb15.json"}}, {"family": "Salas", "given": "Antonio", "initials": "A"}, {"family": "Bello", "given": "Xabier", "initials": "X", "orcid": "0000-0002-4990-8496", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2dd3d12cbc884c8f811d94300bd67ebc.json"}}, {"family": "Pardo-Seco", "given": "Jacobo", "initials": "J"}, {"family": "G\u00f3mez-Carballa", "given": "Alberto", "initials": "A"}, {"family": "Rivero-Calle", "given": "Irene", "initials": "I"}, {"family": "Martin\u00f3n-Torres", "given": "Federico", "initials": "F"}, {"family": "Ganna", "given": "Andrea", "initials": "A"}, {"family": "Karczewski", "given": "Konrad J", "initials": "KJ", "orcid": "0000-0003-2878-4671", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/803dc14ee46c4c648056d01629e645c8.json"}}, {"family": "Veerapen", "given": "Kumar", "initials": "K"}, {"family": "Bourgey", "given": "Mathieu", "initials": "M", "orcid": "0000-0002-8432-834X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ed235e927a940d6a93a61be66137fec.json"}}, {"family": "Bourque", "given": "Guillaume", "initials": "G", "orcid": "0000-0002-3933-9656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7cf09c10c8d64159a13257ec588633c0.json"}}, {"family": "Eveleigh", "given": "Robert Jm", "initials": "RJ", "orcid": "0000-0002-4147-382X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3163112690e04d5abefa4f00b0d42948.json"}}, {"family": "Forgetta", "given": "Vincenzo", "initials": "V"}, {"family": "Morrison", "given": "David", "initials": "D", "orcid": "0000-0001-8380-3615", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6099e7b5999e486eb486bac1f455fdc1.json"}}, {"family": "Langlais", "given": "David", "initials": "D", "orcid": "0000-0003-4429-0110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6c1d5ffed164e62897e5df85e398629.json"}}, {"family": "Lathrop", "given": "Mark", "initials": "M"}, {"family": "Mooser", "given": "Vincent", "initials": "V", "orcid": "0000-0002-8632-0448", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7af40c95aeaf4dd7ab639b31f773b89a.json"}}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T", "orcid": "0000-0001-9510-5646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd273e50091d44c3b3e8d1473ce89b0a.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Marincevic-Zuniga", "given": "Yanara", "initials": "Y"}, {"family": "Nordlund", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8699-9959", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/63952dae96884221862363826c33746d.json"}}, {"family": "Schiabor Barrett", "given": "Kelly M", "initials": "KM", "orcid": "0000-0001-6194-787X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea0e8ac97dcf4591b579c2eae23ff5e9.json"}}, {"family": "Lee", "given": "William", "initials": "W"}, {"family": "Bolze", "given": "Alexandre", "initials": "A", "orcid": "0000-0001-7399-2766", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45c4e714f3054be69533f8d87f686485.json"}}, {"family": "White", "given": "Simon", "initials": "S", "orcid": "0000-0001-6375-2363", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d73512e150e04226b9862d24daa9c4fb.json"}}, {"family": "Riffle", "given": "Stephen", "initials": "S"}, {"family": "Tanudjaja", "given": "Francisco", "initials": "F"}, {"family": "Sandoval", "given": "Efren", "initials": "E"}, {"family": "Neveux", "given": "Iva", "initials": "I"}, {"family": "Dabe", "given": "Shaun", "initials": "S", "orcid": "0000-0002-2494-962X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d819354f7ed4d30b2d1df61905c9091.json"}}, {"family": "Casadei", "given": "Nicolas", "initials": "N", "orcid": "0000-0003-2209-0580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/413e813f99f8432e982e8849e446a716.json"}}, {"family": "Motameny", "given": "Susanne", "initials": "S", "orcid": "0000-0003-1186-1108", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db935de3e5b44cd99512cfb6342c8214.json"}}, {"family": "Alaamery", "given": "Manal", "initials": "M"}, {"family": "Massadeh", "given": "Salam", "initials": "S", "orcid": "0000-0001-9193-0008", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3214967d998b47c0bc9662c4b1157b2b.json"}}, {"family": "Aljawini", "given": "Nora", "initials": "N"}, {"family": "Almutairi", "given": "Mansour S", "initials": "MS", "orcid": "0000-0003-2736-8991", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51120e073f95436399117a8a0f568de1.json"}}, {"family": "Arabi", "given": "Yaseen M", "initials": "YM", "orcid": "0000-0001-5735-6241", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52d3898b4fb44f53b7d80475874d4894.json"}}, {"family": "Alqahtani", "given": "Saleh A", "initials": "SA"}, {"family": "Al Harthi", "given": "Fawz S", "initials": "FS"}, {"family": "Almutairi", "given": "Amal", "initials": "A"}, {"family": "Alqubaishi", "given": "Fatima", "initials": "F"}, {"family": "Alotaibi", "given": "Sarah", "initials": "S"}, {"family": "Binowayn", "given": "Albandari", "initials": "A"}, {"family": "Alsolm", "given": "Ebtehal A", "initials": "EA"}, {"family": "El Bardisy", "given": "Hadeel", "initials": "H"}, {"family": "Fawzy", "given": "Mohammad", "initials": "M", "orcid": "0000-0002-1318-9979", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6fe7222738b54cb09fce2d5128dcb393.json"}}, {"family": "Cai", "given": "Fang", "initials": "F"}, {"family": "Soranzo", "given": "Nicole", "initials": "N"}, {"family": "Butterworth", "given": "Adam", "initials": "A"}, {"family": "COVID-19 Host Genetics Initiative", "given": "", "initials": ""}, {"family": "DeCOI Host Genetics Group", "given": "", "initials": ""}, {"family": "GEN-COVID Multicenter Study (Italy)", "given": "", "initials": ""}, {"family": "Mount Sinai Clinical Intelligence Center", "given": "", "initials": ""}, {"family": "GEN-COVID consortium (Spain)", "given": "", "initials": ""}, {"family": "GenOMICC Consortium", "given": "", "initials": ""}, {"family": "Japan COVID-19 Task Force", "given": "", "initials": ""}, {"family": "Regeneron Genetics Center", "given": "", "initials": ""}, {"family": "Geschwind", "given": "Daniel H", "initials": "DH"}, {"family": "Arteaga", "given": "Stephanie", "initials": "S", "orcid": "0000-0003-1441-8849", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/652a5da6ce8e4c9bbfdbfe8f11768938.json"}}, {"family": "Stephens", "given": "Alexis", "initials": "A", "orcid": "0000-0002-5979-6838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/249f5a87985a463ab89b8f6f1022d829.json"}}, {"family": "Butte", "given": "Manish J", "initials": "MJ"}, {"family": "Boutros", "given": "Paul C", "initials": "PC"}, {"family": "Yamaguchi", "given": "Takafumi N", "initials": "TN", "orcid": "0000-0003-1082-3871", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac413398e38e48e4bb9f5b94cbf99a11.json"}}, {"family": "Tao", "given": "Shu", "initials": "S"}, {"family": "Eng", "given": "Stefan", "initials": "S", "orcid": "0000-0002-5245-6507", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d618fa1da8142b3bc9a30a86b0b4d1a.json"}}, {"family": "Sanders", "given": "Timothy", "initials": "T"}, {"family": "Tung", "given": "Paul J", "initials": "PJ"}, {"family": "Broudy", "given": "Michael E", "initials": "ME"}, {"family": "Pan", "given": "Yu", "initials": "Y"}, {"family": "Gonzalez", "given": "Alfredo", "initials": "A", "orcid": "0000-0001-8963-3135", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/331f872ae2894743b97ff14504d0324f.json"}}, {"family": "Chavan", "given": "Nikhil", "initials": "N"}, {"family": "Johnson", "given": "Ruth", "initials": "R", "orcid": "0000-0002-1929-0998", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77d872b3614a484dbabd0a66cf12c73a.json"}}, {"family": "Pasaniuc", "given": "Bogdan", "initials": "B"}, {"family": "Yaspan", "given": "Brian", "initials": "B", "orcid": "0000-0002-3787-2510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aaf6d84f442e4b09be17a2b0639db758.json"}}, {"family": "Smieszek", "given": "Sandra", "initials": "S", "orcid": "0000-0002-8006-0454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df8cabc7e6c543d880de72e68357e1b4.json"}}, {"family": "Rivolta", "given": "Carlo", "initials": "C", "orcid": "0000-0002-0733-9950", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91f3a7aa91a64175880dcc3c2e615c11.json"}}, {"family": "Bibert", "given": "Stephanie", "initials": "S"}, {"family": "Bochud", "given": "Pierre-Yves", "initials": "PY", "orcid": "0000-0002-2208-4757", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae5a5781ed614965b039e94739bf7a6a.json"}}, {"family": "Dabrowski", "given": "Maciej", "initials": "M", "orcid": "0000-0003-4150-3985", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a678606a0aa340559fe7916f806af31b.json"}}, {"family": "Zawadzki", "given": "Pawel", "initials": "P", "orcid": "0000-0002-9032-2315", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7695a8653b4e4b878878179e87bc9cc3.json"}}, {"family": "Sypniewski", "given": "Mateusz", "initials": "M"}, {"family": "Kaja", "given": "El\u017cbieta", "initials": "E", "orcid": "0000-0003-1277-6140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb9f22b55cae4da1834f8c3bfb741b59.json"}}, {"family": "Chariyavilaskul", "given": "Pajaree", "initials": "P", "orcid": "0000-0003-1096-6020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/beb2b4f73a5a410891031c2afe2fd6a4.json"}}, {"family": "Nilaratanakul", "given": "Voraphoj", "initials": "V", "orcid": "0000-0002-3964-5477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2ac1d215e144f699c8e5787a90df3cd.json"}}, {"family": "Hirankarn", "given": "Nattiya", "initials": "N", "orcid": "0000-0003-2224-6856", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9073cb795dd4839aa2cda851ba84000.json"}}, {"family": "Shotelersuk", "given": "Vorasuk", "initials": "V", "orcid": "0000-0002-1856-0589", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56f21402edbc4312aa672bf78f0dae0d.json"}}, {"family": "Pongpanich", "given": "Monnat", "initials": "M", "orcid": "0000-0003-3228-3351", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9051b469fa614e62a7b10d4e6ea2db86.json"}}, {"family": "Phokaew", "given": "Chureerat", "initials": "C", "orcid": "0000-0002-4246-2604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2be4f5c04e004ed9a6c61f2d47b0a101.json"}}, {"family": "Chetruengchai", "given": "Wanna", "initials": "W", "orcid": "0000-0003-2495-6595", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78faacad098041d4a386cce12d17c840.json"}}, {"family": "Tokunaga", "given": "Katsushi", "initials": "K"}, {"family": "Sugiyama", "given": "Masaya", "initials": "M", "orcid": "0000-0002-9084-7197", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/834495fe76c64a05a17f430dce9ad007.json"}}, {"family": "Kawai", "given": "Yosuke", "initials": "Y", "orcid": "0000-0003-0666-1224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33862e88b2774937a071237159822561.json"}}, {"family": "Hasegawa", "given": "Takanori", "initials": "T", "orcid": "0000-0001-7251-9950", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/342adeed9885409dbedc94c991dccd3e.json"}}, {"family": "Naito", "given": "Tatsuhiko", "initials": "T"}, {"family": "Namkoong", "given": "Ho", "initials": "H", "orcid": "0000-0001-6181-4284", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cf9a27fc9a6409990b1c5871bdddc90.json"}}, {"family": "Edahiro", "given": "Ryuya", "initials": "R"}, {"family": "Kimura", "given": "Akinori", "initials": "A"}, {"family": "Ogawa", "given": "Seishi", "initials": "S"}, {"family": "Kanai", "given": "Takanori", "initials": "T"}, {"family": "Fukunaga", "given": "Koichi", "initials": "K"}, {"family": "Okada", "given": "Yukinori", "initials": "Y"}, {"family": "Imoto", "given": "Seiya", "initials": "S"}, {"family": "Miyano", "given": "Satoru", "initials": "S", "orcid": "0000-0002-1753-6616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec9d5bbdbac34335906afc0dede1a0df.json"}}, {"family": "Mangul", "given": "Serghei", "initials": "S", "orcid": "0000-0003-4770-3443", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dbe15e382e84d38a0fd859377e39d47.json"}}, {"family": "Abedalthagafi", "given": "Malak S", "initials": "MS"}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ee1510080704cf6a2a6972deb94123f.json"}}, {"family": "Grzymski", "given": "Joseph J", "initials": "JJ", "orcid": "0000-0003-2646-8958", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/212250cafa7b4966914ad7455303c2be.json"}}, {"family": "Washington", "given": "Nicole L", "initials": "NL"}, {"family": "Ossowski", "given": "Stephan", "initials": "S", "orcid": "0000-0002-7416-9568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37310c6c082042b8a743635afd381644.json"}}, {"family": "Ludwig", "given": "Kerstin U", "initials": "KU", "orcid": "0000-0002-8541-2519", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02922a1f71c64a8e9dc6aa1c29a20270.json"}}, {"family": "Schulte", "given": "Eva C", "initials": "EC", "orcid": "0000-0003-3105-5672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b02ec0962cdc4e15853c4a3aeba4992d.json"}}, {"family": "Riess", "given": "Olaf", "initials": "O"}, {"family": "Moniuszko", "given": "Marcin", "initials": "M"}, {"family": "Kwasniewski", "given": "Miroslaw", "initials": "M"}, {"family": "Mbarek", "given": "Hamdi", "initials": "H"}, {"family": "Ismail", "given": "Said I", "initials": "SI"}, {"family": "Verma", "given": "Anurag", "initials": "A", "orcid": "0000-0002-5063-9107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ce606e23fdc4de8865ebb196fde5601.json"}}, {"family": "Goldstein", "given": "David B", "initials": "DB", "orcid": "0000-0001-7627-0259", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5954b96aeb15472bb7bc014760f1ba0b.json"}}, {"family": "Kiryluk", "given": "Krzysztof", "initials": "K", "orcid": "0000-0002-5047-6715", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d1362394dec4a7e934fd6c79ad94df3.json"}}, {"family": "Renieri", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-0846-9220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6388ba45f89d4c3b94c4c6c88f97cadb.json"}}, {"family": "Ferreira", "given": "Manuel A R", "initials": "MAR"}, {"family": "Richards", "given": "J Brent", "initials": "JB", "orcid": "0000-0002-3746-9086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8994152547ee4765b1653b834c52a21a.json"}}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "PLoS Genet", "issn": "1553-7404", "volume": "18", "issue": "11", "pages": "e1010367", "issn-l": null}, "abstract": "Host genetics is a key determinant of COVID-19 outcomes. Previously, the COVID-19 Host Genetics Initiative genome-wide association study used common variants to identify multiple loci associated with COVID-19 outcomes. However, variants with the largest impact on COVID-19 outcomes are expected to be rare in the population. Hence, studying rare variants may provide additional insights into disease susceptibility and pathogenesis, thereby informing therapeutics development. Here, we combined whole-exome and whole-genome sequencing from 21 cohorts across 12 countries and performed rare variant exome-wide burden analyses for COVID-19 outcomes. In an analysis of 5,085 severe disease cases and 571,737 controls, we observed that carrying a rare deleterious variant in the SARS-CoV-2 sensor toll-like receptor TLR7 (on chromosome X) was associated with a 5.3-fold increase in severe disease (95% CI: 2.75-10.05, p = 5.41x10-7). This association was consistent across sexes. These results further support TLR7 as a genetic determinant of severe disease and suggest that larger studies on rare variants influencing COVID-19 outcomes could provide additional insights.", "doi": "10.1371/journal.pgen.1010367", "pmid": "36327219", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9632827"}, {"db": "pii", "key": "PGENETICS-D-22-00434"}, {"db": "URL", "key": "https://github.com/DrGBL/WES.WGS", "description": "https://github.com/DrGBL/WES.WGS"}], "notes": [], "created": "2022-11-29T16:14:29.516Z", "modified": "2022-11-29T16:15:32.496Z"}, {"entity": "publication", "iuid": "6d229c4662244bc9a1951205596cb20c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6d229c4662244bc9a1951205596cb20c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6d229c4662244bc9a1951205596cb20c"}}, "title": "COVID-19 Information in Sweden: Opinions of Immigrants with Limited Proficiency in Swedish.", "authors": [{"family": "Roble", "given": "Sagal", "initials": "S"}, {"family": "W\u00e5ngdahl", "given": "Josefin", "initials": "J"}, {"family": "Warner", "given": "Georgina", "initials": "G", "orcid": "0000-0002-7850-9136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a44058151a6c4ff4be148921ad1e9e57.json"}}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "Health Commun", "issn": "1532-7027", "volume": "37", "issue": "12", "pages": "1510-1519", "issn-l": null}, "abstract": "COVID-19 has highlighted the importance of health information for prevention of communicable disease. Knowledge about groups that have high risk is important to prevent disease transmission. In Sweden, immigrants have been identified as one such group. Yet, little is known about where they have sourced information about COVID-19 and their opinions toward it. The aim of this study was to describe the COVID-19 information sources used by immigrants with limited proficiency in Swedish as well as their opinions on how comprehensive the information has been, the importance of the recommendations and their possibility to follow them. A cross-sectional survey was conducted via introductory Swedish language classes in Region Uppsala (n = 855). The results showed the immigrants were using different information sources, with the majority using school, media and social media. The immigrants' opinions about COVID-19 information differed. Most reported they knew where to find information; however, over two-fifths reported the recommendations from the authorities should be more extensive. The majority reported it is important to follow the recommendations, whereas the possibility to follow the recommendations was more mixed. Age differences in opinions toward COVID-19 information were detected. Although the results were largely positive, there still appears to be a need for improvement in how immigrant groups with limited ability in the host country\u00b4s language are reached. Effective health communication that engages the whole nation is an important factor authorities should commit to as we face the current pandemic. This research suggests that an approach tailored by age could be helpful.", "doi": "10.1080/10410236.2022.2050005", "pmid": "35287507", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-01-13T13:25:27.113Z", "modified": "2023-01-13T13:25:27.159Z"}, {"entity": "publication", "iuid": "3ae9d08a217348928d2628f0596b0ff2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ae9d08a217348928d2628f0596b0ff2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ae9d08a217348928d2628f0596b0ff2"}}, "title": "B-cell repopulation dynamics and drug pharmacokinetics impact SARS-CoV-2 vaccine efficacy in anti-CD20-treated multiple sclerosis patients.", "authors": [{"family": "Asplund H\u00f6gelin", "given": "Klara", "initials": "K", "orcid": "0000-0002-3696-355X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e30a564a8ac14f97af8d46d222dff3ab.json"}}, {"family": "Ruffin", "given": "Nicolas", "initials": "N"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Starvaggi Cucuzza", "given": "Chiara", "initials": "C"}, {"family": "Khademi", "given": "Mohsen", "initials": "M"}, {"family": "Olsson", "given": "Tomas", "initials": "T"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Al Nimer", "given": "Faiez", "initials": "F"}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "Eur J Neurol", "issn": "1468-1331", "issn-l": null, "volume": "29", "issue": "11", "pages": "3317-3328"}, "abstract": "Recent findings document a blunted humoral response to SARS-CoV-2 vaccination in patients on anti-CD20 treatment. Although most patients develop a cellular response, it is still important to identify predictors of seroconversion to optimize vaccine responses.\n\nWe determined antibody responses after SARS-CoV-2 vaccination in a real-world cohort of multiple sclerosis patients (n = 94) treated with anti-CD20, mainly rituximab, with variable treatment duration (median = 2.9, range = 0.4-9.6 years) and time from last anti-CD20 infusion to vaccination (median = 190, range = 60-1032 days).\n\nWe find that presence of B cells and/or rituximab in blood predict seroconversion better than time since last infusion. Using multiple logistic regression, presence of >0.5% B cells increased probability of seroconversion with an odds ratio (OR) of 5.0 (95% confidence interval [CI] = 1.0-28.1, p = 0.055), whereas the corresponding OR for \u22656 months since last infusion was 1.45 (95% CI = 0.20-10.15, p = 0.705). In contrast, detectable rituximab levels were negatively associated with seroconversion (OR = 0.05, 95% CI = 0.002-0.392, p = 0.012). Furthermore, na\u00efve and memory IgG+ B cells correlated with antibody levels. Although retreatment with rituximab at 4 weeks or more after booster depleted spike-specific B cells, it did not noticeably affect the rate of decline in antibody titers. Interferon-\u03b3 and/or interleukin-13 T-cell responses to the spike S1 domain were observed in most patients, but with no correlation to spike antibody levels.\n\nThese findings are relevant for providing individualized guidance to patients and planning of vaccination schemes, in turn optimizing benefit-risk with anti-CD20.", "doi": "10.1111/ene.15492", "pmid": "35808856", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Vaccines": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Vaccine": null}, "xrefs": [{"db": "pmc", "key": "PMC9349816"}], "notes": [], "created": "2022-08-15T14:47:44.894Z", "modified": "2022-10-17T14:51:58.545Z"}, {"entity": "publication", "iuid": "66b4f38551804f02a4d51ce775bafc3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66b4f38551804f02a4d51ce775bafc3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66b4f38551804f02a4d51ce775bafc3d"}}, "title": "Differential Bias for Creatinine- and Cystatin C- Derived Estimated Glomerular Filtration Rate in Critical COVID-19.", "authors": [{"family": "Larsson", "given": "Anders O", "initials": "AO", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2be858ab604743b72383dfdcd14689.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Nyman", "given": "Ulf", "initials": "U"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Eriksson", "given": "Mats B", "initials": "MB", "orcid": "0000-0002-3178-4210", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c90375295094966a51f9d17c275abb6.json"}}], "type": "journal article", "published": "2022-10-26", "journal": {"title": "Biomedicines", "issn": "2227-9059", "volume": "10", "issue": "11", "issn-l": null}, "abstract": "COVID-19 is a systemic disease, frequently affecting kidney function. Dexamethasone is standard treatment in severe COVID-19 cases, and is considered to increase plasma levels of cystatin C. However, this has not been studied in COVID-19. Glomerular filtration rate (GFR) is a clinically important indicator of renal function, but often estimated using equations (eGFR) based on filtered metabolites. This study focuses on sources of bias for eGFRs (mL/min) using a creatinine-based equation (eGFRLMR) and a cystatin C-based equation (eGFRCAPA) in intensive-care-treated patients with COVID-19. This study was performed on 351 patients aged 18 years old or above with severe COVID-19 infections, admitted to the intensive care unit (ICU) in Uppsala University Hospital, a tertiary care hospital in Uppsala, Sweden, between 14 March 2020 and 10 March 2021. Dexamethasone treatment (6 mg for up to 10 days) was introduced 22 June 2020 (n = 232). Values are presented as medians (IQR). eGFRCAPA in dexamethasone-treated patients was 69 (37), and 74 (46) in patients not given dexamethasone (p = 0.01). eGFRLMR was not affected by dexamethasone. eGFRLMR in females was 94 (20), and 75 (38) in males (p = 0.00001). Age and maximal CRP correlated negatively to eGFRCAPA and eGFRLMR, whereas both eGFR equations correlated positively to BMI. In ICU patients with COVID-19, dexamethasone treatment was associated with reduced eGFRCAPA. This finding may be explained by corticosteroid-induced increases in plasma cystatin C. This observation is important from a clinical perspective since adequate interpretation of laboratory results is crucial.", "doi": "10.3390/biomedicines10112708", "pmid": "36359231", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "biomedicines10112708"}], "notes": [], "created": "2022-11-25T10:46:17.171Z", "modified": "2022-11-25T10:46:17.220Z"}, {"entity": "publication", "iuid": "fbe760843fc148f79d4d40761ba99f43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fbe760843fc148f79d4d40761ba99f43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fbe760843fc148f79d4d40761ba99f43"}}, "title": "Do Comorbidities and Daily Medication before SARS-CoV-2 Infection Play a Role in Self-Reported Post-Infection Symptoms?", "authors": [{"family": "Va\u017eg\u0117lien\u0117", "given": "Dovil\u0117", "initials": "D"}, {"family": "Kubilius", "given": "Raimondas", "initials": "R"}, {"family": "Bileviciute-Ljungar", "given": "Indre", "initials": "I"}], "type": "journal article", "published": "2022-10-25", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "11", "issue": "21", "issn-l": "2077-0383"}, "abstract": "This study investigated the associations between health status before SARS-CoV-2 infection and persistent symptoms after acute infection. Data were collected from participants older than 18 years and more than 28 days after acute SARS-CoV-2 infection using an online survey. Sociodemographic data, comorbidities, and daily medication before infection, as well as acute and persistent symptoms were analysed. Among the 1050 participants (mean age 41 years, 88% women, 56% with higher education, 93% working), 538 (51%) reported being healthy and 762 (73%) reported not taking any daily medication prior to infection. Positive laboratory testing was reported by 965 (92%) participants; asymptomatic infection was reported by 30 (3%); and 999 (95%) stayed at home during their acute infection. Reduced physical capacity (40%), fatigue (39%), cognitive difficulties (30-34%), altered sense of smell (24%), headache (20%), tachycardia (20%), unstable mood (19%), hair loss (17%), and insomnia (17%) were the most often reported symptoms. Those taking daily medication before infection reported increased frequency of both acute and persistent symptoms, except for decreased frequency of persistent altered smell and taste. The presence of persistent symptoms was predicted by taking daily medication before infection and by the total number of acute symptoms. Comorbidities before infection did not predict persistent symptoms. Therefore, the role of medication needs further investigation in both acute SARS-CoV-2 infection and post-COVID-19 condition.", "doi": "10.3390/jcm11216278", "pmid": "36362506", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9657459"}, {"db": "pii", "key": "jcm11216278"}], "notes": [], "created": "2022-11-25T10:45:26.774Z", "modified": "2022-11-25T10:45:39.432Z"}, {"entity": "publication", "iuid": "7d7cf123a0dc4d75bd5aa3ca0a0759dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d7cf123a0dc4d75bd5aa3ca0a0759dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d7cf123a0dc4d75bd5aa3ca0a0759dd"}}, "title": "A Multiparametric and High-Throughput Platform for Host-Virus Binding Screens", "authors": [{"family": "Schlegel", "given": "Jan", "initials": "J"}, {"family": "Porebski", "given": "Bartlomiej", "initials": "B"}, {"family": "Andronico", "given": "Luca", "initials": "L"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Edwards", "given": "Steven", "initials": "S"}, {"family": "Brismar", "given": "Hjalmar", "initials": "H"}, {"family": "Murrell", "given": "Benjamin", "initials": "B"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Fernandez-Capetillo", "given": "Oscar", "initials": "O"}, {"family": "Sezgin", "given": "Erdinc", "initials": "E", "orcid": "0000-0002-4915-388X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30c3688527ac4caf8d07426703ace615.json"}}], "type": "posted-content", "published": "2022-10-11", "journal": {"title": "Medrxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.10.10.511545", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-12-01T13:38:49.854Z", "modified": "2023-01-27T13:01:57.807Z"}, {"entity": "publication", "iuid": "2a24a52cd8c84a8eb843e15301deda1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2a24a52cd8c84a8eb843e15301deda1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2a24a52cd8c84a8eb843e15301deda1d"}}, "title": "Estimated Global Proportions of Individuals With Persistent Fatigue, Cognitive, and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021.", "authors": [{"family": "Global Burden of Disease Long COVID Collaborators", "given": "", "initials": ""}, {"family": "Wulf Hanson", "given": "Sarah", "initials": "S"}, {"family": "Abbafati", "given": "Cristiana", "initials": "C"}, {"family": "Aerts", "given": "Joachim G", "initials": "JG"}, {"family": "Al-Aly", "given": "Ziyad", "initials": "Z"}, {"family": "Ashbaugh", "given": "Charlie", "initials": "C"}, {"family": "Ballouz", "given": "Tala", "initials": "T"}, {"family": "Blyuss", "given": "Oleg", "initials": "O"}, {"family": "Bobkova", "given": "Polina", "initials": "P"}, {"family": "Bonsel", "given": "Gouke", "initials": "G"}, {"family": "Borzakova", "given": "Svetlana", "initials": "S"}, {"family": "Buonsenso", "given": "Danilo", "initials": "D"}, {"family": "Butnaru", "given": "Denis", "initials": "D"}, {"family": "Carter", "given": "Austin", "initials": "A"}, {"family": "Chu", "given": "Helen", "initials": "H"}, {"family": "De Rose", "given": "Cristina", "initials": "C"}, {"family": "Diab", "given": "Mohamed Mustafa", "initials": "MM"}, {"family": "Ekbom", "given": "Emil", "initials": "E"}, {"family": "El Tantawi", "given": "Maha", "initials": "M"}, {"family": "Fomin", "given": "Victor", "initials": "V"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Gamirova", "given": "Aysylu", "initials": "A"}, {"family": "Glybochko", "given": "Petr V", "initials": "PV"}, {"family": "Haagsma", "given": "Juanita A", "initials": "JA"}, {"family": "Haghjooy Javanmard", "given": "Shaghayegh", "initials": "S"}, {"family": "Hamilton", "given": "Erin B", "initials": "EB"}, {"family": "Harris", "given": "Gabrielle", "initials": "G"}, {"family": "Heijenbrok-Kal", "given": "Majanka H", "initials": "MH"}, {"family": "Helbok", "given": "Raimund", "initials": "R"}, {"family": "Hellemons", "given": "Merel E", "initials": "ME"}, {"family": "Hillus", "given": "David", "initials": "D"}, {"family": "Huijts", "given": "Susanne M", "initials": "SM"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Jassat", "given": "Waasila", "initials": "W"}, {"family": "Kurth", "given": "Florian", "initials": "F"}, {"family": "Larsson", "given": "Ing-Marie", "initials": "IM"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Liu", "given": "Chelsea", "initials": "C"}, {"family": "Loflin", "given": "Callan D", "initials": "CD"}, {"family": "Malinovschi", "given": "Andrei", "initials": "A"}, {"family": "Mao", "given": "Wenhui", "initials": "W"}, {"family": "Mazankova", "given": "Lyudmila", "initials": "L"}, {"family": "McCulloch", "given": "Denise", "initials": "D"}, {"family": "Menges", "given": "Dominik", "initials": "D"}, {"family": "Mohammadifard", "given": "Noushin", "initials": "N"}, {"family": "Munblit", "given": "Daniel", "initials": "D"}, {"family": "Nekliudov", "given": "Nikita A", "initials": "NA"}, {"family": "Ogbuoji", "given": "Osondu", "initials": "O"}, {"family": "Osmanov", "given": "Ismail M", "initials": "IM"}, {"family": "Pe\u00f1alvo", "given": "Jos\u00e9 L", "initials": "JL"}, {"family": "Petersen", "given": "Maria Skaalum", "initials": "MS"}, {"family": "Puhan", "given": "Milo A", "initials": "MA"}, {"family": "Rahman", "given": "Mujibur", "initials": "M"}, {"family": "Rass", "given": "Verena", "initials": "V"}, {"family": "Reinig", "given": "Nickolas", "initials": "N"}, {"family": "Ribbers", "given": "Gerard M", "initials": "GM"}, {"family": "Ricchiuto", "given": "Antonia", "initials": "A"}, {"family": "Rubertsson", "given": "Sten", "initials": "S"}, {"family": "Samitova", "given": "Elmira", "initials": "E"}, {"family": "Sarrafzadegan", "given": "Nizal", "initials": "N"}, {"family": "Shikhaleva", "given": "Anastasia", "initials": "A"}, {"family": "Simpson", "given": "Kyle E", "initials": "KE"}, {"family": "Sinatti", "given": "Dario", "initials": "D"}, {"family": "Soriano", "given": "Joan B", "initials": "JB"}, {"family": "Spiridonova", "given": "Ekaterina", "initials": "E"}, {"family": "Steinbeis", "given": "Fridolin", "initials": "F"}, {"family": "Svistunov", "given": "Andrey A", "initials": "AA"}, {"family": "Valentini", "given": "Piero", "initials": "P"}, {"family": "van de Water", "given": "Brittney J", "initials": "BJ"}, {"family": "van den Berg-Emons", "given": "Rita", "initials": "R"}, {"family": "Wallin", "given": "Ewa", "initials": "E"}, {"family": "Witzenrath", "given": "Martin", "initials": "M"}, {"family": "Wu", "given": "Yifan", "initials": "Y"}, {"family": "Xu", "given": "Hanzhang", "initials": "H"}, {"family": "Zoller", "given": "Thomas", "initials": "T"}, {"family": "Adolph", "given": "Christopher", "initials": "C"}, {"family": "Albright", "given": "James", "initials": "J"}, {"family": "Amlag", "given": "Joanne O", "initials": "JO"}, {"family": "Aravkin", "given": "Aleksandr Y", "initials": "AY"}, {"family": "Bang-Jensen", "given": "Bree L", "initials": "BL"}, {"family": "Bisignano", "given": "Catherine", "initials": "C"}, {"family": "Castellano", "given": "Rachel", "initials": "R"}, {"family": "Castro", "given": "Emma", "initials": "E"}, {"family": "Chakrabarti", "given": "Suman", "initials": "S"}, {"family": "Collins", "given": "James K", "initials": "JK"}, {"family": "Dai", "given": "Xiaochen", "initials": "X"}, {"family": "Daoud", "given": "Farah", "initials": "F"}, {"family": "Dapper", "given": "Carolyn", "initials": "C"}, {"family": "Deen", "given": "Amanda", "initials": "A"}, {"family": "Duncan", "given": "Bruce B", "initials": "BB"}, {"family": "Erickson", "given": "Megan", "initials": "M"}, {"family": "Ewald", "given": "Samuel B", "initials": "SB"}, {"family": "Ferrari", "given": "Alize J", "initials": "AJ"}, {"family": "Flaxman", "given": "Abraham D", "initials": "AD"}, {"family": "Fullman", "given": "Nancy", "initials": "N"}, {"family": "Gamkrelidze", "given": "Amiran", "initials": "A"}, {"family": "Giles", "given": "John R", "initials": "JR"}, {"family": "Guo", "given": "Gaorui", "initials": "G"}, {"family": "Hay", "given": "Simon I", "initials": "SI"}, {"family": "He", "given": "Jiawei", "initials": "J"}, {"family": "Helak", "given": "Monika", "initials": "M"}, {"family": "Hulland", "given": "Erin N", "initials": "EN"}, {"family": "Kereselidze", "given": "Maia", "initials": "M"}, {"family": "Krohn", "given": "Kris J", "initials": "KJ"}, {"family": "Lazzar-Atwood", "given": "Alice", "initials": "A"}, {"family": "Lindstrom", "given": "Akiaja", "initials": "A"}, {"family": "Lozano", "given": "Rafael", "initials": "R"}, {"family": "Malta", "given": "Deborah Carvalho", "initials": "DC"}, {"family": "M\u00e5nsson", "given": "Johan", "initials": "J"}, {"family": "Mantilla Herrera", "given": "Ana M", "initials": "AM"}, {"family": "Mokdad", "given": "Ali H", "initials": "AH"}, {"family": "Monasta", "given": "Lorenzo", "initials": "L"}, {"family": "Nomura", "given": "Shuhei", "initials": "S"}, {"family": "Pasovic", "given": "Maja", "initials": "M"}, {"family": "Pigott", "given": "David M", "initials": "DM"}, {"family": "Reiner", "given": "Robert C", "initials": "RC"}, {"family": "Reinke", "given": "Grace", "initials": "G"}, {"family": "Ribeiro", "given": "Antonio Luiz P", "initials": "ALP"}, {"family": "Santomauro", "given": "Damian Francesco", "initials": "DF"}, {"family": "Sholokhov", "given": "Aleksei", "initials": "A"}, {"family": "Spurlock", "given": "Emma Elizabeth", "initials": "EE"}, {"family": "Walcott", "given": "Rebecca", "initials": "R"}, {"family": "Walker", "given": "Ally", "initials": "A"}, {"family": "Wiysonge", "given": "Charles Shey", "initials": "CS"}, {"family": "Zheng", "given": "Peng", "initials": "P"}, {"family": "Bettger", "given": "Janet Prvu", "initials": "JP"}, {"family": "Murray", "given": "Christopher J L", "initials": "CJL"}, {"family": "Vos", "given": "Theo", "initials": "T"}], "type": "journal article", "published": "2022-10-10", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484"}, "abstract": "Some individuals experience persistent symptoms after initial symptomatic SARS-CoV-2 infection (often referred to as Long COVID).\n\nTo estimate the proportion of males and females with COVID-19, younger or older than 20 years of age, who had Long COVID symptoms in 2020 and 2021 and their Long COVID symptom duration.\n\nBayesian meta-regression and pooling of 54 studies and 2 medical record databases with data for 1.2 million individuals (from 22 countries) who had symptomatic SARS-CoV-2 infection. Of the 54 studies, 44 were published and 10 were collaborating cohorts (conducted in Austria, the Faroe Islands, Germany, Iran, Italy, the Netherlands, Russia, Sweden, Switzerland, and the US). The participant data were derived from the 44 published studies (10 501 hospitalized individuals and 42 891 nonhospitalized individuals), the 10 collaborating cohort studies (10 526 and 1906), and the 2 US electronic medical record databases (250 928 and 846 046). Data collection spanned March 2020 to January 2022.\n\nSymptomatic SARS-CoV-2 infection.\n\nProportion of individuals with at least 1 of the 3 self-reported Long COVID symptom clusters (persistent fatigue with bodily pain or mood swings; cognitive problems; or ongoing respiratory problems) 3 months after SARS-CoV-2 infection in 2020 and 2021, estimated separately for hospitalized and nonhospitalized individuals aged 20 years or older by sex and for both sexes of nonhospitalized individuals younger than 20 years of age.\n\nA total of 1.2 million individuals who had symptomatic SARS-CoV-2 infection were included (mean age, 4-66 years; males, 26%-88%). In the modeled estimates, 6.2% (95% uncertainty interval [UI], 2.4%-13.3%) of individuals who had symptomatic SARS-CoV-2 infection experienced at least 1 of the 3 Long COVID symptom clusters in 2020 and 2021, including 3.2% (95% UI, 0.6%-10.0%) for persistent fatigue with bodily pain or mood swings, 3.7% (95% UI, 0.9%-9.6%) for ongoing respiratory problems, and 2.2% (95% UI, 0.3%-7.6%) for cognitive problems after adjusting for health status before COVID-19, comprising an estimated 51.0% (95% UI, 16.9%-92.4%), 60.4% (95% UI, 18.9%-89.1%), and 35.4% (95% UI, 9.4%-75.1%), respectively, of Long COVID cases. The Long COVID symptom clusters were more common in women aged 20 years or older (10.6% [95% UI, 4.3%-22.2%]) 3 months after symptomatic SARS-CoV-2 infection than in men aged 20 years or older (5.4% [95% UI, 2.2%-11.7%]). Both sexes younger than 20 years of age were estimated to be affected in 2.8% (95% UI, 0.9%-7.0%) of symptomatic SARS-CoV-2 infections. The estimated mean Long COVID symptom cluster duration was 9.0 months (95% UI, 7.0-12.0 months) among hospitalized individuals and 4.0 months (95% UI, 3.6-4.6 months) among nonhospitalized individuals. Among individuals with Long COVID symptoms 3 months after symptomatic SARS-CoV-2 infection, an estimated 15.1% (95% UI, 10.3%-21.1%) continued to experience symptoms at 12 months.\n\nThis study presents modeled estimates of the proportion of individuals with at least 1 of 3 self-reported Long COVID symptom clusters (persistent fatigue with bodily pain or mood swings; cognitive problems; or ongoing respiratory problems) 3 months after symptomatic SARS-CoV-2 infection.", "doi": "10.1001/jama.2022.18931", "pmid": "36215063", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "2797443"}], "notes": [], "created": "2022-10-17T14:46:34.295Z", "modified": "2022-10-17T14:47:20.543Z"}, {"entity": "publication", "iuid": "74a421fbdf7a4c958ee21843c31befa5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/74a421fbdf7a4c958ee21843c31befa5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/74a421fbdf7a4c958ee21843c31befa5"}}, "title": "Anti-Spike Mucosal IgA Protection against SARS-CoV-2 Omicron Infection.", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f28f2f6ac9648629c2d2de92fe7bb59.json"}}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Svensson", "given": "Julia", "initials": "J"}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Bacchus", "given": "Philip", "initials": "P", "orcid": "0000-0001-9800-1957", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77e288f7a3b94f6181c7c515273081b0.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "letter", "published": "2022-10-06", "journal": {"title": "N Engl J Med", "issn": "1533-4406", "volume": "387", "issue": "14", "pages": "1333-1336", "issn-l": null}, "abstract": null, "doi": "10.1056/NEJMc2209651", "pmid": "36103621", "labels": {"Category: Omicron VoC": null, "Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9511632"}], "notes": [], "created": "2022-10-13T12:55:59.528Z", "modified": "2023-06-19T14:27:04.997Z"}, {"entity": "publication", "iuid": "92c8bd61f38f45bd9d0efd0d0ebde090", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/92c8bd61f38f45bd9d0efd0d0ebde090.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/92c8bd61f38f45bd9d0efd0d0ebde090"}}, "title": "A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses.", "authors": [{"family": "Lenart", "given": "Klara", "initials": "K"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Ols", "given": "Sebastian", "initials": "S"}, {"family": "Yan", "given": "Xianglei", "initials": "X"}, {"family": "Cagigi", "given": "Alberto", "initials": "A"}, {"family": "Cerveira", "given": "Rodrigo Arcoverde", "initials": "RA"}, {"family": "Winge", "given": "Inga", "initials": "I"}, {"family": "Hanczak", "given": "Jakub", "initials": "J"}, {"family": "Mueller", "given": "Stefan O", "initials": "SO"}, {"family": "Jasny", "given": "Edith", "initials": "E"}, {"family": "Schwendt", "given": "Kim", "initials": "K"}, {"family": "Rauch", "given": "Susanne", "initials": "S"}, {"family": "Petsch", "given": "Benjamin", "initials": "B"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2022-10-06", "journal": {"title": "Mol Ther Methods Clin Dev", "issn": "2329-0501", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "A third vaccine dose is often required to achieve potent, long-lasting immune responses. We investigated the impact of three 8 \u03bcg doses of CVnCoV, CureVac's SARS-CoV-2 vaccine candidate containing sequence-optimized unmodified mRNA encoding spike (S) glycoprotein, administered at 0, 4 and 28 weeks on immune responses in rhesus macaques. Following the third dose S-specific binding and neutralizing antibodies increased 50-fold compared with post-dose 2 levels, with increased responses also evident in the lower airways and against the SARS-CoV-2 B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma) and B.1.617.2 (Delta) variants. Enhanced binding affinity of serum antibodies after the third dose correlated with higher somatic hypermutation in S-specific B cells, corresponding with improved binding properties of monoclonal antibodies expressed from isolated B cells. Administration of low dose mRNA led to fewer cells expressing antigen in vivo at the injection site and in the draining lymph nodes compared with a tenfold higher dose, possibly reducing the engagement of precursor cells with the antigen and resulting in the suboptimal response observed following two-dose vaccination schedules in phase IIb/III clinical trials of CVnCoV. However, when immune memory is established, a third dose efficiently boosts the immunological responses as well as improves antibody affinity and breadth.", "doi": "10.1016/j.omtm.2022.10.001", "pmid": "36217434", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Category: Vaccines": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Research Area: Vaccine": null}, "xrefs": [{"db": "pii", "key": "S2329-0501(22)00143-7"}, {"db": "pmc", "key": "PMC9535876"}], "notes": [], "created": "2022-10-13T15:23:38.735Z", "modified": "2022-10-17T14:57:33.385Z"}, {"entity": "publication", "iuid": "74f12da206e64e47a7de84c81a08e340", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/74f12da206e64e47a7de84c81a08e340.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/74f12da206e64e47a7de84c81a08e340"}}, "title": "A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA Viruses.", "authors": [{"family": "Lindqvist", "given": "Richard", "initials": "R"}, {"family": "Benz", "given": "Caroline", "initials": "C", "orcid": "0000-0002-5166-3598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13332514bfe7460db4a0f134718aa211.json"}}, {"family": "Sereikaite", "given": "Vita", "initials": "V"}, {"family": "Maassen", "given": "Lars", "initials": "L"}, {"family": "Laursen", "given": "Louise", "initials": "L"}, {"family": "Jemth", "given": "Per", "initials": "P", "orcid": "0000-0003-1516-7228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c5fe566cf5f44df9c98bb2b1d7078ba.json"}}, {"family": "Str\u00f8mgaard", "given": "Kristian", "initials": "K"}, {"family": "Ivarsson", "given": "Ylva", "initials": "Y"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK", "orcid": "0000-0001-6553-0940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9024ab251cf44bffbf3229ec909343af.json"}}], "type": "journal article", "published": "2022-10-06", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "10", "pages": "2202", "issn-l": "1999-4915"}, "abstract": "Viruses are dependent on host factors in order to efficiently establish an infection and replicate. Targeting the interactions of such host factors provides an attractive strategy to develop novel antivirals. Syntenin is a protein known to regulate the architecture of cellular membranes by its involvement in protein trafficking and has previously been shown to be important for human papilloma virus (HPV) infection. Here, we show that a highly potent and metabolically stable peptide inhibitor that binds to the PDZ1 domain of syntenin inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by blocking the endosomal entry of the virus. Furthermore, we found that the inhibitor also hampered chikungunya infection and strongly reduced flavivirus infection, which is completely dependent on receptor-mediated endocytosis for their entry. In conclusion, we have identified a novel broad spectrum antiviral inhibitor that efficiently targets a broad range of RNA viruses.", "doi": "10.3390/v14102202", "pmid": "36298757", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC9610207"}, {"db": "pii", "key": "v14102202"}], "notes": [], "created": "2022-10-31T17:26:05.478Z", "modified": "2023-06-19T15:04:01.062Z"}, {"entity": "publication", "iuid": "f47961871afa4d0dbb206f09276a3324", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f47961871afa4d0dbb206f09276a3324.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f47961871afa4d0dbb206f09276a3324"}}, "title": "A regression discontinuity analysis of the social distancing recommendations for older adults in Sweden during COVID-19.", "authors": [{"family": "Bonander", "given": "Carl", "initials": "C", "orcid": "0000-0002-1189-9950", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/386ac82b1a4843828b503ec807c08206.json"}}, {"family": "Stranges", "given": "Debora", "initials": "D", "orcid": "0000-0002-1782-8563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26d57656ec964be89179420faace6222.json"}}, {"family": "Gustavsson", "given": "Johanna", "initials": "J"}, {"family": "Almgren", "given": "Matilda", "initials": "M", "orcid": "0000-0003-1555-8069", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/faba1c6d698d4dffbca95ff4ee838626.json"}}, {"family": "Inghammar", "given": "Malin", "initials": "M"}, {"family": "Moghaddassi", "given": "Mahnaz", "initials": "M", "orcid": "0000-0002-0844-4736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a219bde5ba8a4f3f8655ada08d749885.json"}}, {"family": "Nilsson", "given": "Anton", "initials": "A", "orcid": "0000-0001-5774-7189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/915c1fe25c1d43c3ba55c5793d5e59be.json"}}, {"family": "Capdevila Pujol", "given": "Joan", "initials": "J"}, {"family": "Steves", "given": "Claire", "initials": "C"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Gomez", "given": "Maria F", "initials": "MF"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J", "orcid": "0000-0003-1883-2000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e88fdca336ae41c891f0a46e2481b67f.json"}}, {"family": "COVID Symptom Study Sweden", "given": "", "initials": ""}], "type": "journal article", "published": "2022-10-03", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": "32", "issue": "5", "pages": "799-806"}, "abstract": "This article investigates the impact of a non-mandatory and age-specific social distancing recommendation on isolation behaviours and disease outcomes in Sweden during the first wave of the coronavirus disease 2019 (COVID-19) pandemic (March to July 2020). The policy stated that people aged 70 years or older should avoid crowded places and contact with people outside the household.\n\nWe used a regression discontinuity design-in combination with self-reported isolation data from COVID Symptom Study Sweden (n = 96 053; age range: 39-79 years) and national register data (age range: 39-100+ years) on severe COVID-19 disease (hospitalization or death, n = 21 804) and confirmed cases (n = 48 984)-to estimate the effects of the policy.\n\nOur primary analyses showed a sharp drop in the weekly number of visits to crowded places (-13%) and severe COVID-19 cases (-16%) at the 70-year threshold. These results imply that the age-specific recommendations prevented approximately 1800-2700 severe COVID-19 cases, depending on model specification.\n\nIt seems that the non-mandatory, age-specific recommendations helped control COVID-19 disease during the first wave of the pandemic in Sweden, as opposed to not implementing a social distancing policy aimed at older adults. Our study provides empirical data on how populations may react to non-mandatory, age-specific social distancing policies in the face of a novel virus.", "doi": "10.1093/eurpub/ckac101", "pmid": "35962987", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9384721"}, {"db": "pii", "key": "6665904"}], "notes": [], "created": "2022-08-15T15:25:45.226Z", "modified": "2023-06-19T07:42:36.510Z"}, {"entity": "publication", "iuid": "a7a6bb5249734d7f8974f2cde50ef35a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7a6bb5249734d7f8974f2cde50ef35a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7a6bb5249734d7f8974f2cde50ef35a"}}, "title": "Probing effects of the SARS-CoV-2 E protein on membrane curvature and intracellular calcium.", "authors": [{"family": "Mehregan", "given": "Aujan", "initials": "A"}, {"family": "P\u00e9rez-Conesa", "given": "Sergio", "initials": "S"}, {"family": "Zhuang", "given": "Yuxuan", "initials": "Y"}, {"family": "Elbahnsi", "given": "Ahmad", "initials": "A"}, {"family": "Pasini", "given": "Diletta", "initials": "D"}, {"family": "Lindahl", "given": "Erik", "initials": "E"}, {"family": "Howard", "given": "Rebecca J", "initials": "RJ"}, {"family": "Ulens", "given": "Chris", "initials": "C"}, {"family": "Delemotte", "given": "Lucie", "initials": "L", "orcid": "0000-0002-0828-3899", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c75eddd4cc64423e9899dba6115a26c9.json"}}], "type": "journal article", "published": "2022-10-01", "journal": {"title": "Biochim Biophys Acta Biomembr", "issn": "1879-2642", "issn-l": null, "volume": "1864", "issue": "10", "pages": "183994"}, "abstract": "SARS-CoV-2 contains four structural proteins in its genome. These proteins aid in the assembly and budding of new virions at the ER-Golgi intermediate compartment (ERGIC). Current fundamental research efforts largely focus on one of these proteins - the spike (S) protein. Since successful antiviral therapies are likely to target multiple viral components, there is considerable interest in understanding the biophysical role of its other structural proteins, in particular structural membrane proteins. Here, we have focused our efforts on the characterization of the full-length envelope (E) protein from SARS-CoV-2, combining experimental and computational approaches. Recombinant expression of the full-length E protein from SARS-CoV-2 reveals that this membrane protein is capable of independent multimerization, possibly as a tetrameric or smaller species. Fluorescence microscopy shows that the protein localizes intracellularly, and coarse-grained MD simulations indicate it causes bending of the surrounding lipid bilayer, corroborating a potential role for the E protein in viral budding. Although we did not find robust electrophysiological evidence of ion-channel activity, cells transfected with the E protein exhibited reduced intracellular Ca2+, which may further promote viral replication. However, our atomistic MD simulations revealed that previous NMR structures are relatively unstable, and result in models incapable of ion conduction. Our study highlights the importance of using high-resolution structural data obtained from a full-length protein to gain detailed molecular insights, and eventually permitting virtual drug screening.", "doi": "10.1016/j.bbamem.2022.183994", "pmid": "35724739", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: VR": null, "Category: Imaging": null, "Funder: KAW/SciLifeLab": null, "Research Area: Drug discovery and repurposing of drugs": null}, "xrefs": [{"db": "pmc", "key": "PMC9212275"}, {"db": "pii", "key": "S0005-2736(22)00132-8"}], "notes": [], "created": "2022-08-15T13:04:26.500Z", "modified": "2023-10-04T08:21:52.816Z"}, {"entity": "publication", "iuid": "23211eab6ea84a5cb42fac597ead9172", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23211eab6ea84a5cb42fac597ead9172.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23211eab6ea84a5cb42fac597ead9172"}}, "title": "Association of COVID-19 Infection With Wearing Glasses in a High-Prevalence Area in Denmark and Sweden.", "authors": [{"family": "Gregersen", "given": "Rasmus", "initials": "R"}, {"family": "Jacobsen", "given": "Rikke Kart", "initials": "RK"}, {"family": "Laursen", "given": "Jannie", "initials": "J"}, {"family": "Mobech", "given": "Regine", "initials": "R"}, {"family": "Ostrowski", "given": "Sisse Rye", "initials": "SR"}, {"family": "Iversen", "given": "Kasper", "initials": "K"}, {"family": "Petersen", "given": "Janne", "initials": "J"}], "type": "journal article", "published": "2022-10-01", "journal": {"title": "JAMA Ophthalmol", "issn": "2168-6173", "volume": "140", "issue": "10", "pages": "957-964", "issn-l": null}, "abstract": "Observational studies have indicated that glasses might protect against contracting COVID-19 through reduced airborne and contact transmission.\n\nTo investigate the association between wearing one's own glasses with contracting COVID-19 when adjusting for relevant confounders.\n\nThis cohort study was conducted during the first wave of the COVID-19 pandemic (June to August 2020) in Denmark and Sweden, where personal protective equipment was not recommended for the general population at the time. Employees at Falck, an international rescue corps with different job functions (ambulance, health care, office, and field staff, firefighters, and roadside assistance) participated in the study.\n\nThe main exposure was wearing glasses (also including contact lenses and reading glasses), which was assessed in a questionnaire. Persons wearing glasses were compared with those who did not wear glasses (ie, nonusers). To adjust for potential confounders, information on age, sex, job function, and number of workday contacts were included.\n\nThe outcome was COVID-19 infection before (positive polymerase chain reaction test) or during the study period (biweekly voluntary tests with a rapid test). The investigated hypothesis was formulated after collecting the data.\n\nA total of 1279 employees in Denmark and 841 in Sweden were included (839 [39.6%] female and 1281 [60.4%] male; 20.5% were aged <40 years; 57.0%, 40-60 years, and 22.5%, >60 years). Of these, 829 individuals (64.8%) in Denmark and 619 (73.6%) in Sweden wore glasses. Wearing glasses was inversely associated with COVID-19 infection in the Swedish cohort (odds ratio [OR], 0.61 [95% CI, 0.37-0.99]; P = .047; seroprevalence, 9.3%) but not in the Danish cohort (OR, 1.14 [95% CI, 0.53-2.45]; P = .73; seroprevalence, 2.4%). Adjusting for age, sex, job function, and number of workday contacts in Sweden, wearing glasses no longer was associated with COVID-19 infection (OR, 0.64 [95% CI, 0.37-1.11]; P = .11). When stratifying by job function, a large difference was observed among office staff (OR, 0.20 [95% CI, 0.06-0.70]; P = .01) but not ambulance staff (OR, 0.83 [95% CI, 0.41-1.67]; P = .60) nor health care staff (OR, 0.89 [95% CI, 0.35-2.30]; P = .81).\n\nWhile wearing one's glasses was inversely associated with COVID-19 in Sweden in an unadjusted analysis, an association no longer was identified when adjusting for confounders. These results provide inconclusive findings regarding whether wearing one's own glasses is associated with a decreased risk of COVID-19 infections.", "doi": "10.1001/jamaophthalmol.2022.3234", "pmid": "36006635", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9412836"}, {"db": "pii", "key": "2795676"}], "notes": [], "created": "2022-08-26T04:42:09.969Z", "modified": "2023-01-13T13:33:16.749Z"}, {"entity": "publication", "iuid": "ae405af650f2480a8b7b65aee874a1ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ae405af650f2480a8b7b65aee874a1ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ae405af650f2480a8b7b65aee874a1ae"}}, "title": "Years of life lost during the Covid-19 pandemic in Sweden considering variation in life expectancy by level of geriatric care.", "authors": [{"family": "Ebeling", "given": "Marcus", "initials": "M", "orcid": "0000-0002-6531-8525", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68c1d52cda8f44b08a880cff988da4fe.json"}}, {"family": "Acosta", "given": "Enrique", "initials": "E", "orcid": "0000-0001-6250-4018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58eb2562f719445ca58bbe4767ff3c05.json"}}, {"family": "Caswell", "given": "Hal", "initials": "H", "orcid": "0000-0003-4394-6894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cc33d38bae1411d99d1cb998c10b407.json"}}, {"family": "Meyer", "given": "Anna C", "initials": "AC", "orcid": "0000-0003-2749-7179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/85b259806e24408cba7ef935931c0cc9.json"}}, {"family": "Modig", "given": "Karin", "initials": "K", "orcid": "0000-0002-5151-4867", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b60a410c326c43df8256b3ffd7cd38d4.json"}}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "Eur J Epidemiol", "issn": "1573-7284", "volume": "37", "issue": "10", "pages": "1025-1034", "issn-l": "0393-2990"}, "abstract": "The Covid-19 pandemic has not affected the population evenly. This must be acknowledged when it comes to understanding the Covid-19 death toll and answering the question of how many life years have been lost. We use level of geriatric care to account for variation in remaining life expectancy among individuals that died during 2020. Based on a linkage of administrative registers, we estimate remaining life expectancy stratified by age, sex, and care status using an incidence-based multistate model and analyze the number of years of life lost (YLL) during 2020 in Sweden. Our results show that remaining life expectancy between individuals with and without care differs substantially. More than half of all Covid-19 deaths had a remaining life expectancy lower than 4 years. Yet, in a 1-year perspective, Covid-19 did not seem to replace other causes of death. Not considering the differences in remaining life expectancy in the affected populations overestimated YLL by 40% for women and 30% for men, or around 2 years per death. While the unadjusted YLL from Covid-19 amounted to an average of 7.5 years for women and 8.6 years for men, the corresponding YLL adjusted for care status were 5.4 and 6.6, respectively. The total number of YLL to Covid-19 in 2020 is comparable to YLL from ischemic heart disease in 2019 and 2020. Our results urge the use of subgroup specific mortality when counting the burden of Covid-19. YLL are considerably reduced when the varying susceptibility for death is considered, but even if most lifespans were cut in the last years of life, the YLL are still substantial.", "doi": "10.1007/s10654-022-00915-z", "pmid": "36127511", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9488891"}, {"db": "pii", "key": "10.1007/s10654-022-00915-z"}], "notes": [], "created": "2023-01-13T13:53:50.160Z", "modified": "2023-01-13T13:53:50.311Z"}, {"entity": "publication", "iuid": "43e0662d439441f38ff4e351cb71c5e0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/43e0662d439441f38ff4e351cb71c5e0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/43e0662d439441f38ff4e351cb71c5e0"}}, "title": "The Dual Pandemics of COVID-19 and Obesity: Bidirectional Impact.", "authors": [{"family": "Kapoor", "given": "Nitin", "initials": "N"}, {"family": "Kalra", "given": "Sanjay", "initials": "S"}, {"family": "Al Mahmeed", "given": "Wael", "initials": "W"}, {"family": "Al-Rasadi", "given": "Khalid", "initials": "K"}, {"family": "Al-Alawi", "given": "Kamila", "initials": "K"}, {"family": "Banach", "given": "Maciej", "initials": "M"}, {"family": "Banerjee", "given": "Yajnavalka", "initials": "Y"}, {"family": "Ceriello", "given": "Antonio", "initials": "A"}, {"family": "Cesur", "given": "Mustafa", "initials": "M"}, {"family": "Cosentino", "given": "Francesco", "initials": "F"}, {"family": "Firenze", "given": "Alberto", "initials": "A"}, {"family": "Galia", "given": "Massimo", "initials": "M"}, {"family": "Goh", "given": "Su-Yen", "initials": "S"}, {"family": "Janez", "given": "Andrej", "initials": "A"}, {"family": "Kempler", "given": "Peter", "initials": "P"}, {"family": "Lessan", "given": "Nader", "initials": "N"}, {"family": "Lotufo", "given": "Paulo", "initials": "P"}, {"family": "Papanas", "given": "Nikolaos", "initials": "N"}, {"family": "Rizvi", "given": "Ali A", "initials": "AA"}, {"family": "Sahebkar", "given": "Amirhossein", "initials": "A"}, {"family": "Santos", "given": "Raul D", "initials": "RD"}, {"family": "Stoian", "given": "Anca Pantea", "initials": "AP"}, {"family": "Toth", "given": "Peter P", "initials": "PP"}, {"family": "Viswanathan", "given": "Vijay", "initials": "V"}, {"family": "Rizzo", "given": "Manfredi", "initials": "M"}, {"family": "CArdiometabolic Panel of International experts on Syndemic COvid-19 (CAPISCO)", "given": "", "initials": ""}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "Diabetes Ther", "issn": "1869-6953", "issn-l": null, "volume": "13", "issue": "10", "pages": "1723-1736"}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the COVID-19 pandemic, has been shown to disrupt many organ systems in the human body. Though several medical disorders have been affected by this infection, a few illnesses in addition may also play a role in determining the outcome of COVID-19. Obesity is one such disease which is not only affected by the occurrence of COVID-19 but can also result in a worse clinical outcome of COVID-19 infection. This manuscript summarizes the most recent evidence supporting the bidirectional impact of COVID-19 and obesity. It highlights how the presence of obesity can be detrimental to the outcome of COVID-19 in a given patient because of the mechanical limitations in lung compliance and also by the activation of several thrombo-inflammatory pathways. The sociodemographic changes brought about by the pandemic in turn have facilitated the already increasing prevalence of obesity. This manuscript highlights the importance of recognizing these pathways which may further help in policy changes that facilitate appropriate measures to prevent the further worsening of these two pandemics.", "doi": "10.1007/s13300-022-01311-2", "pmid": "36030317", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s13300-022-01311-2"}, {"db": "pmc", "key": "PMC9419639"}], "notes": [], "created": "2022-10-07T12:40:52.100Z", "modified": "2022-10-07T12:41:32.075Z"}, {"entity": "publication", "iuid": "0a56301865724fb4907f0e0c27be5a82", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a56301865724fb4907f0e0c27be5a82.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a56301865724fb4907f0e0c27be5a82"}}, "title": "Severity of COVID19 infection among patients with multiple sclerosis treated with interferon-\u03b2.", "authors": [{"family": "Simpson-Yap", "given": "Steve", "initials": "S", "orcid": "0000-0001-6521-3056", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/845cbea3a2f64b9f880a43d6cc8cdb09.json"}}, {"family": "Pirmani", "given": "Ashkan", "initials": "A"}, {"family": "De Brouwer", "given": "Edward", "initials": "E"}, {"family": "Peeters", "given": "Liesbet M", "initials": "LM"}, {"family": "Geys", "given": "Lotte", "initials": "L"}, {"family": "Parciak", "given": "Tina", "initials": "T"}, {"family": "Helme", "given": "Anne", "initials": "A"}, {"family": "Hillert", "given": "Jan", "initials": "J"}, {"family": "Moreau", "given": "Yves", "initials": "Y"}, {"family": "Edan", "given": "Gilles", "initials": "G"}, {"family": "Spelman", "given": "Tim", "initials": "T"}, {"family": "Sharmin", "given": "Sifat", "initials": "S"}, {"family": "McBurney", "given": "Robert", "initials": "R"}, {"family": "Schmidt", "given": "Hollie", "initials": "H"}, {"family": "Bergmann", "given": "Arnfin", "initials": "A"}, {"family": "Braune", "given": "Stefan", "initials": "S"}, {"family": "Stahmann", "given": "Alexander", "initials": "A"}, {"family": "Middleton", "given": "Rodden", "initials": "R"}, {"family": "Salter", "given": "Amber", "initials": "A"}, {"family": "Bebo", "given": "Bruce", "initials": "B"}, {"family": "van der Walt", "given": "Anneke", "initials": "A"}, {"family": "Butzkueven", "given": "Helmut", "initials": "H"}, {"family": "Ozakbas", "given": "Serkan", "initials": "S"}, {"family": "Karabudak", "given": "Rana", "initials": "R"}, {"family": "Boz", "given": "Cavit", "initials": "C"}, {"family": "Alroughani", "given": "Raed", "initials": "R"}, {"family": "Rojas", "given": "Juan I", "initials": "JI"}, {"family": "van der Mei", "given": "Ingrid", "initials": "I"}, {"family": "Sciascia do Olival", "given": "Guilherme", "initials": "G"}, {"family": "Magyari", "given": "Melinda", "initials": "M"}, {"family": "Alonso", "given": "Ricardo", "initials": "R"}, {"family": "Nicholas", "given": "Richard", "initials": "R"}, {"family": "Chertcoff", "given": "Anibal", "initials": "A"}, {"family": "Zabalza", "given": "Ana", "initials": "A"}, {"family": "Arrambide", "given": "Georgina", "initials": "G"}, {"family": "Nag", "given": "Nupur", "initials": "N"}, {"family": "Descamps", "given": "Annabel", "initials": "A"}, {"family": "Costers", "given": "Lars", "initials": "L"}, {"family": "Dobson", "given": "Ruth", "initials": "R"}, {"family": "Miller", "given": "Aleisha", "initials": "A"}, {"family": "Rodrigues", "given": "Paulo", "initials": "P"}, {"family": "Pr\u010dkovska", "given": "Vesna", "initials": "V"}, {"family": "Comi", "given": "Giancarlo", "initials": "G"}, {"family": "Kalincik", "given": "Tomas", "initials": "T"}], "type": "letter", "published": "2022-10-00", "journal": {"title": "Mult Scler Relat Disord", "issn": "2211-0356", "volume": "66", "pages": "104072", "issn-l": null}, "abstract": "Interferon-\u03b2, a disease-modifying therapy (DMT) for MS, may be associated with less severe COVID-19 in people with MS.\n\nAmong 5,568 patients (83.4% confirmed COVID-19), interferon-treated patients had lower risk of severe COVID-19 compared to untreated, but not to glatiramer-acetate, dimethyl-fumarate, or pooled other DMTs.\n\nIn comparison to other DMTs, we did not find evidence of protective effects of interferon-\u03b2 on the severity of COVID-19, though compared to the untreated, the course of COVID19 was milder among those on interferon-\u03b2. This study does not support the use of interferon-\u03b2 as a treatment to reduce COVID-19 severity in MS.", "doi": "10.1016/j.msard.2022.104072", "pmid": "35917745", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9310378"}, {"db": "pii", "key": "S2211-0348(22)00580-6"}], "notes": [], "created": "2022-08-11T12:02:34.852Z", "modified": "2023-06-19T14:41:22.654Z"}, {"entity": "publication", "iuid": "125837694ec841ec8b0ab596b5e550a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/125837694ec841ec8b0ab596b5e550a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/125837694ec841ec8b0ab596b5e550a6"}}, "title": "Severe COVID-19 in people 55 and older during the first year of the pandemic in Sweden.", "authors": [{"family": "Rosengren", "given": "Annika", "initials": "A"}, {"family": "Lundberg", "given": "Christina E", "initials": "CE"}, {"family": "S\u00f6derberg", "given": "Mia", "initials": "M"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Edqvist", "given": "Jon", "initials": "J"}, {"family": "Lindgren", "given": "Martin", "initials": "M"}, {"family": "\u00c5berg", "given": "Maria", "initials": "M"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Robertson", "given": "Josefina", "initials": "J"}, {"family": "Cronie", "given": "Ottmar", "initials": "O"}, {"family": "Sattar", "given": "Naveed", "initials": "N"}, {"family": "Lagergren", "given": "Jesper", "initials": "J"}, {"family": "Brand\u00e9n", "given": "Maria", "initials": "M"}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}, {"family": "Adiels", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": "292", "issue": "4", "pages": "641-653"}, "abstract": "Exposure to many contacts is the main risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, while risk of serious disease and death is chiefly determined by old age and comorbidities. Relative and population-attributable fractions (PAFs) of multiple medical and social exposures for COVID-19 outcomes have not been evaluated among older adults.\r\n\r\nWe describe the effect of multiple exposures on the odds of testing positive for the virus and of severe disease (hospital care or death) and PAFs in Swedish citizens aged 55 years and above.\r\n\r\nWe used national registers to follow all citizens aged 55 years and above with respect to (1) testing positive, (2) hospitalization, and (3) death between 31 January 2020 and 1 February 2021.\r\n\r\nOf 3,410,241 persons, 156,017 (4.6%, mean age 68.3 years) tested positive for SARS-CoV-2, while 35,999 (1.1%, mean age 76.7 years) were hospitalized or died (12,384 deaths, 0.4%, mean age 84.0 years). Among the total cohort, the proportion living without home care or long-term care was 98.8% among persons aged 55-64 and 22.1% of those aged 95 and above. After multiple adjustment, home care and long-term care were associated with odds ratios of 7.9 (95% confidence interval [CI] 6.8-9.1) and 22.5 (95% CI 19.6-25.7) for mortality, with PAFs of 21.9% (95% CI 20.9-22.9) and 33.3% (95% CI 32.4-34.3), respectively.\r\n\r\nAmong Swedish residents aged 55 years and above, those with home care or long-term care had markedly increased risk for COVID-19 death during the first year of the pandemic, with over 50% of deaths attributable to these factors.", "doi": "10.1111/joim.13522", "pmid": "35612518", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC9348046"}], "notes": [], "created": "2022-06-21T17:51:17.657Z", "modified": "2022-10-13T14:39:34.245Z"}, {"entity": "publication", "iuid": "c247a0d7b8c6418b9ab769b6a49da500", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c247a0d7b8c6418b9ab769b6a49da500.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c247a0d7b8c6418b9ab769b6a49da500"}}, "title": "SARS-CoV-2 spike protein aggregation is triggered by bacterial lipopolysaccharide.", "authors": [{"family": "Petrlova", "given": "Jitka", "initials": "J", "orcid": "0000-0002-7554-3945", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a58aee20cb4847d99c9b307c76fdda74.json"}}, {"family": "Samsudin", "given": "Firdaus", "initials": "F"}, {"family": "Bond", "given": "Peter J", "initials": "PJ"}, {"family": "Schmidtchen", "given": "Artur", "initials": "A", "orcid": "0000-0001-9209-3141", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/426e00c7c8314ea195f2670af469e19a.json"}}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "FEBS Lett", "issn": "1873-3468", "volume": "596", "issue": "19", "pages": "2566-2575", "issn-l": null}, "abstract": "SARS-CoV-2 spike (S) protein is crucial for virus invasion in COVID-19. Here, we showed that lipopolysaccharide (LPS) can trigger S protein aggregation at high doses of LPS and S protein. We demonstrated the formation of S protein aggregates by microscopy analyses, aggregation and gel shift assays. LPS at high levels boosts the formation of S protein aggregates as detected by amytracker and thioflavin T dyes that specifically bind to aggregating proteins. We validated the role of LPS by blocking the formation of aggregates by the endotoxin-scavenging thrombin-derived peptide TCP-25. Aggregation-prone sequences in S protein are predicted to be nearby LPS binding sites, while molecular simulations showed stable formation of S protein-LPS higher-order oligomers. Collectively, our results provide evidence of LPS-induced S protein aggregation.", "doi": "10.1002/1873-3468.14490", "pmid": "36050806", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9538650"}], "notes": [], "created": "2022-10-13T13:15:42.794Z", "modified": "2022-10-13T13:17:51.776Z"}, {"entity": "publication", "iuid": "9a98809b3327409e8e37fc73fd45ad63", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9a98809b3327409e8e37fc73fd45ad63.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9a98809b3327409e8e37fc73fd45ad63"}}, "title": "No effect of remdesivir or betamethasone on upper respiratory tract SARS-CoV-2 RNA kinetics in hospitalised COVID-19 patients: a retrospective observational study.", "authors": [{"family": "Sourander", "given": "Birger", "initials": "B"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "L"}, {"family": "Brink", "given": "Magnus", "initials": "M"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Sundell", "given": "Nicklas", "initials": "N"}, {"family": "Marklund", "given": "Emelie", "initials": "E"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Robertson", "given": "Josefina", "initials": "J"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": "54", "issue": "10", "pages": "703-712"}, "abstract": "The viral kinetics of SARS-CoV-2 has been considered clinically important. While remdesivir and corticosteroids are recommended for COVID-19 patients requiring oxygen support, there is a limited number of published reports on viral kinetics in hospitalised patients with COVID-19 treated with remdesivir or corticosteroids.\r\n\r\nWe conducted a retrospective study by collecting longitudinal samples from the nasopharynx/throat of 123 hospitalised patients (median age 55 years, 74% male) with COVID-19, to evaluate the effects of remdesivir and corticosteroid treatment on viral RNA levels. The subjects were divided into four groups: those receiving remdesivir (n = 25), betamethasone (n = 41), both (n = 15), or neither (n = 42). Time to viral RNA clearance was analysed using Kaplan-Meier plots, categorical data were analysed using Fisher's exact test, and Kruskal-Wallis for continuous data. Viral RNA decline rate was analysed using a mixed effect model.\r\n\r\nWe found no significant difference in SARS-CoV-2 RNA decline rate or time to SARS-CoV-2 RNA clearance between the groups. Moreover, clinical status at baseline was not correlated with time to viral clearance.\r\n\r\nSince SARS-CoV-2 RNA kinetics was not affected by treatment, repeated sampling from the upper respiratory tract cannot be used to evaluate treatment response.", "doi": "10.1080/23744235.2022.2081716", "pmid": "35708280", "labels": {"Category: Drug Discovery": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2022-06-20T18:10:19.043Z", "modified": "2022-10-13T14:40:38.264Z"}, {"entity": "publication", "iuid": "a59e71c204fc4f40a3f4d5c31324c22b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a59e71c204fc4f40a3f4d5c31324c22b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a59e71c204fc4f40a3f4d5c31324c22b"}}, "title": "Infection Rate of SARS-CoV-2 in Asymptomatic Healthcare Workers, Sweden, June 2022.", "authors": [{"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Norin", "given": "Nina Greilert", "initials": "NG"}, {"family": "Bacchus", "given": "Philip", "initials": "P"}, {"family": "Groenheit", "given": "Ramona", "initials": "R"}, {"family": "Br\u00e5ve", "given": "Andreas", "initials": "A"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}], "type": "letter", "published": "2022-10-00", "journal": {"title": "Emerg Infect Dis", "issn": "1080-6059", "volume": "28", "issue": "10", "pages": "2119-2121", "issn-l": null}, "abstract": "Given the recent surge in SARS-CoV-2 Omicron infections, we performed a quantitative PCR screening survey during June 28-29, 2022, in Stockholm, Sweden, to investigate SARS-CoV-2 point prevalence in a group with high exposure risk. Results showed SARS-CoV-2 infection in 2.3% of healthcare workers who were asymptomatic at time of sampling.", "doi": "10.3201/eid2810.221093", "pmid": "35997692", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9514358"}], "notes": [], "created": "2022-08-26T04:45:09.756Z", "modified": "2023-06-19T14:27:18.248Z"}, {"entity": "publication", "iuid": "01c40c37457844aabd726103ec1267ba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01c40c37457844aabd726103ec1267ba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01c40c37457844aabd726103ec1267ba"}}, "title": "Induced abortion and access to contraception in Sweden during the COVID-19 pandemic.", "authors": [{"family": "Niemeyer Hultstrand", "given": "Jenny", "initials": "J", "orcid": "0000-0002-2304-2006", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/abc93f26a58947fea94714306129d45d.json"}}, {"family": "T\u00f6rnroos", "given": "Elin", "initials": "E"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}, {"family": "Larsson", "given": "Margareta I", "initials": "MI"}, {"family": "Makenzius", "given": "Marlene", "initials": "M"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Tyd\u00e9n", "given": "Tanja", "initials": "T"}, {"family": "Ekstrand Ragnar", "given": "Maria", "initials": "M"}], "type": "letter", "published": "2022-10-00", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-2009", "volume": "48", "issue": "4", "pages": "311-312", "issn-l": "2515-1991"}, "abstract": null, "doi": "10.1136/bmjsrh-2022-201464", "pmid": "35332034", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjsrh-2022-201464"}], "notes": [], "created": "2022-04-04T06:58:49.184Z", "modified": "2023-01-13T13:34:18.406Z"}, {"entity": "publication", "iuid": "ac4ad25a4acc4c9ea992394d22cb4c67", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac4ad25a4acc4c9ea992394d22cb4c67.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac4ad25a4acc4c9ea992394d22cb4c67"}}, "title": "Desire to work from home: Results of an Irish study.", "authors": [{"family": "Stefaniec", "given": "Agnieszka", "initials": "A"}, {"family": "Brazil", "given": "William", "initials": "W"}, {"family": "Whitney", "given": "Warren", "initials": "W"}, {"family": "Caulfield", "given": "Brian", "initials": "B"}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "J Transp Geogr", "issn": "0966-6923", "issn-l": null, "volume": "104", "issue": null, "pages": "103416"}, "abstract": "Large levels of working from home (WfH) were induced by social distancing and viral control measures undertaken to mitigate the Covid-19 pandemic. Representing an unpredicted change in the way large amounts of people undertake their day to day work, it is expected that the legacy of this event, in terms of significant alterations to work and commuting patterns will have wide-ranging and long-lasting results. However, how persistent the current trends will be, remains an open question. Therefore, there is a need for a well-represented study of employees' preferences for the post-pandemic future and focus on white-collar workers and their well-established attitudes considering their flexibility in terms of workplace arrangements. This paper presents the results of a survey undertaken in Ireland in the summer of 2021 gauging the desire of office workers to WfH, the format that most appeals to them, the consideration of home relocation based on the ability to WfH, and the factors that may explain such preferences. Results indicate high levels of desire to WfH, either full time or partially, with increased desire to WfH positively correlated to pre-pandemic commute length, and to a perceived increase in work productivity and quality of non-work life as a result of time spent WfH. Additionally, a number of workers state that they may consider home relocation based upon the ability to WfH. These results should be interpreted as the desire to WfH or total addressable market that exists, rather than the likely levels of WfH that will be observed post-Covid.", "doi": "10.1016/j.jtrangeo.2022.103416", "pmid": "35992220", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0966-6923(22)00139-9"}, {"db": "pmc", "key": "PMC9379795"}], "notes": [], "created": "2022-09-12T18:52:28.755Z", "modified": "2022-11-09T08:36:41.448Z"}, {"entity": "publication", "iuid": "3239af756d1f41f3bbfd495afcec99d3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3239af756d1f41f3bbfd495afcec99d3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3239af756d1f41f3bbfd495afcec99d3"}}, "title": "Comprehensive analysis of pathways in Coronavirus 2019 (COVID-19) using an unsupervised machine learning method.", "authors": [{"family": "Taheri", "given": "Golnaz", "initials": "G"}, {"family": "Habibi", "given": "Mahnaz", "initials": "M"}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "Appl Soft Comput", "issn": "1568-4946", "volume": "128", "pages": "109510", "issn-l": null}, "abstract": "The World Health Organization (WHO) introduced \"Coronavirus disease 19\" or \"COVID-19\" as a novel coronavirus in March 2020. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires the fast discovery of effective treatments to fight this worldwide crisis. Artificial intelligence and bioinformatics analysis pipelines can assist with finding biomarkers, explanations, and cures. Artificial intelligence and machine learning methods provide powerful infrastructures for interpreting and understanding the available data. On the other hand, pathway enrichment analysis, as a dominant tool, could help researchers discover potential key targets present in biological pathways of host cells that are targeted by SARS-CoV-2. In this work, we propose a two-stage machine learning approach for pathway analysis. During the first stage, four informative gene sets that can represent important COVID-19 related pathways are selected. These \"representative genes\" are associated with the COVID-19 pathology. Then, two distinctive networks were constructed for COVID-19 related signaling and disease pathways. In the second stage, the pathways of each network are ranked with respect to some unsupervised scorning method based on our defined informative features. Finally, we present a comprehensive analysis of the top important pathways in both networks. Materials and implementations are available at: https://github.com/MahnazHabibi/Pathway.", "doi": "10.1016/j.asoc.2022.109510", "pmid": "35992221", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1568-4946(22)00596-8"}, {"db": "pmc", "key": "PMC9384336"}], "notes": [], "created": "2022-09-12T18:52:34.765Z", "modified": "2022-09-12T18:52:44.843Z"}, {"entity": "publication", "iuid": "2d1ee9ca5d6e413c8099707e881b182c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d1ee9ca5d6e413c8099707e881b182c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d1ee9ca5d6e413c8099707e881b182c"}}, "title": "CODE-EHR best-practice framework for the use of structured electronic health-care records in clinical research.", "authors": [{"family": "Kotecha", "given": "Dipak", "initials": "D"}, {"family": "Asselbergs", "given": "Folkert W", "initials": "FW"}, {"family": "Achenbach", "given": "Stephan", "initials": "S"}, {"family": "Anker", "given": "Stefan D", "initials": "SD"}, {"family": "Atar", "given": "Dan", "initials": "D"}, {"family": "Baigent", "given": "Colin", "initials": "C"}, {"family": "Banerjee", "given": "Amitava", "initials": "A"}, {"family": "Beger", "given": "Birgit", "initials": "B"}, {"family": "Brobert", "given": "Gunnar", "initials": "G"}, {"family": "Casadei", "given": "Barbara", "initials": "B"}, {"family": "Ceccarelli", "given": "Cinzia", "initials": "C"}, {"family": "Cowie", "given": "Martin R", "initials": "MR"}, {"family": "Crea", "given": "Filippo", "initials": "F"}, {"family": "Cronin", "given": "Maureen", "initials": "M"}, {"family": "Denaxas", "given": "Spiros", "initials": "S"}, {"family": "Derix", "given": "Andrea", "initials": "A"}, {"family": "Fitzsimons", "given": "Donna", "initials": "D"}, {"family": "Fredriksson", "given": "Martin", "initials": "M"}, {"family": "Gale", "given": "Chris P", "initials": "CP"}, {"family": "Gkoutos", "given": "Georgios V", "initials": "GV"}, {"family": "Goettsch", "given": "Wim", "initials": "W"}, {"family": "Hemingway", "given": "Harry", "initials": "H"}, {"family": "Ingvar", "given": "Martin", "initials": "M"}, {"family": "Jonas", "given": "Adrian", "initials": "A"}, {"family": "Kazmierski", "given": "Robert", "initials": "R"}, {"family": "L\u00f8gstrup", "given": "Susanne", "initials": "S"}, {"family": "Lumbers", "given": "R Thomas", "initials": "RT"}, {"family": "L\u00fcscher", "given": "Thomas F", "initials": "TF"}, {"family": "McGreavy", "given": "Paul", "initials": "P"}, {"family": "Pi\u00f1a", "given": "Ileana L", "initials": "IL"}, {"family": "Roessig", "given": "Lothar", "initials": "L"}, {"family": "Steinbeisser", "given": "Carl", "initials": "C"}, {"family": "Sundgren", "given": "Mats", "initials": "M"}, {"family": "Tyl", "given": "Beno\u00eet", "initials": "B"}, {"family": "Thiel", "given": "Ghislaine van", "initials": "GV"}, {"family": "Bochove", "given": "Kees van", "initials": "KV"}, {"family": "Vardas", "given": "Panos E", "initials": "PE"}, {"family": "Villanueva", "given": "Tiago", "initials": "T"}, {"family": "Vrana", "given": "Marilena", "initials": "M"}, {"family": "Weber", "given": "Wim", "initials": "W"}, {"family": "Weidinger", "given": "Franz", "initials": "F"}, {"family": "Windecker", "given": "Stephan", "initials": "S"}, {"family": "Wood", "given": "Angela", "initials": "A"}, {"family": "Grobbee", "given": "Diederick E", "initials": "DE"}, {"family": "Innovative Medicines Initiative BigData@Heart Consortium, European Society of Cardiology, and CODE-EHR International Consensus Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "The Lancet Digital Health", "issn": "2589-7500", "volume": "4", "issue": "10", "pages": "e757-e764", "issn-l": null}, "abstract": "Big data is important to new developments in global clinical science that aim to improve the lives of patients. Technological advances have led to the regular use of structured electronic health-care records with the potential to address key deficits in clinical evidence that could improve patient care. The COVID-19 pandemic has shown this potential in big data and related analytics but has also revealed important limitations. Data verification, data validation, data privacy, and a mandate from the public to conduct research are important challenges to effective use of routine health-care data. The European Society of Cardiology and the BigData@Heart consortium have brought together a range of international stakeholders, including representation from patients, clinicians, scientists, regulators, journal editors, and industry members. In this Review, we propose the CODE-EHR minimum standards framework to be used by researchers and clinicians to improve the design of studies and enhance transparency of study methods. The CODE-EHR framework aims to develop robust and effective utilisation of health-care data for research purposes.", "doi": "10.1016/S2589-7500(22)00151-0", "pmid": "36050271", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2589-7500(22)00151-0"}], "notes": [], "created": "2022-10-13T13:06:28.143Z", "modified": "2022-10-13T13:06:28.156Z"}, {"entity": "publication", "iuid": "0f906486a40f462c9c666a0a0e72b164", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0f906486a40f462c9c666a0a0e72b164.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0f906486a40f462c9c666a0a0e72b164"}}, "title": "Favorable Adaptation during SARS-CoV-2-Pandemic as Told by Student-Athletes-A Longitudinal and Behavioral Study.", "authors": [{"family": "Johnson", "given": "Urban", "initials": "U"}, {"family": "Hertting", "given": "Krister", "initials": "K", "orcid": "0000-0003-2347-4391", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98fbb192394e443c8f3feeee090189fe.json"}}, {"family": "Ivarsson", "given": "Andreas", "initials": "A"}, {"family": "Lindgren", "given": "Eva-Carin", "initials": "E"}], "type": "journal article", "published": "2022-09-30", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "19", "issue": "19", "pages": null}, "abstract": "(1) Background: The aim was to explore the impact of adaptive responses (resilience factors) on student-athletes' behaviors during a stressful period of life during the SARS-CoV-2-pandemic of 2020 and 2021. (2) Methods: A constructivist-based grounded theory (CGT) was used guided by a biopsychosocial approach. Based on purposeful sampling, 22 male and female student-athletes were divided into four focus group interviews (FGI) seven months after the outbreak of the SARS-CoV-2-pandemic (October 2020) and 18 of these were followed up by FGI seven months later (May 2021). The mean age was 17.65 and they represented golf and handball. (3) Results: The CGT contained four main categories seven months after the SARS-CoV-2-pandemic outbreak: Social support, Self-discipline, Physical practice and recovery and Management of everyday life. Fourteen months after the SARS-CoV-2-pandemic outbreak, four additional main categories emerged: More extensive social support, Belief in the future, Self-awareness and Responsibility and problem-solving. (4) Conclusions: The CTG suggests that student-athletes' favorable adaptations to the stressful SARS-CoV-2-pandemic period 2020-2021 are based on a gradually developed ability to take responsibility for one's own actions, insight into the importance of deepened social interaction, belief in a positive post-COVID future and increased awareness of physical activity and its relation to perceived health.", "doi": "10.3390/ijerph191912512", "pmid": "36231812", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph191912512"}], "notes": [], "created": "2022-10-17T14:56:32.227Z", "modified": "2022-10-17T14:57:00.351Z"}, {"entity": "publication", "iuid": "7783f0b4be54469c9768b72979029d95", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7783f0b4be54469c9768b72979029d95.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7783f0b4be54469c9768b72979029d95"}}, "title": "Strain on the ICU resources and patient outcomes in the COVID-19 pandemic: A Swedish national registry cohort study.", "authors": [{"family": "Stattin", "given": "Karl", "initials": "K"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Kawati", "given": "Rafael", "initials": "R"}], "type": "journal article", "published": "2022-09-27", "journal": {"title": "Eur J Anaesthesiol", "issn": "1365-2346", "issn-l": null}, "abstract": "The Coronavirus 2019 (COVID-19) pandemic has led to an unprecedented strain on the ICU resources. It is not known how the ICU resources employed in treating COVID-19 patients are related to inpatient characteristics, use of organ support or mortality.\n\nTo investigate how the use of ICU resources relate to use of organ support and mortality in COVID-19 patients.\n\nA national register-based cohort study.\n\nAll Swedish ICUs from March 2020 to November 2021.\n\nAll patients admitted to Swedish ICUs with a primary diagnosis of COVID-19 reported to the national Swedish Intensive Care Register (SIR).\n\nOrgan support (mechanical ventilation, noninvasive ventilation, high-flow oxygen therapy, prone positioning, surgical and percutaneous tracheostomy, central venous catheterisation, continuous renal replacement therapy and intermittent haemodialysis), discharge at night, re-admission, transfer and ICU and 30-day mortality.\n\nSeven thousand nine hundred and sixty-nine patients had a median age of 63 years, and 70% were men. Median daily census was 167% of habitual census, daily new admissions were 20% of habitual census and the median occupancy was 82%. Census and new admissions were associated with mechanical ventilation, OR 1.37 (95% CI 1.28 to 1.48) and OR 1.44 (95% CI 1.13 to 1.84), respectively, but negatively associated with noninvasive ventilation, OR 0.83 (95% CI 0.77 to 0.89) and OR 0.40 (95% CI 0.30 to 52) and high-flow oxygen therapy, OR 0.72 (95% CI 0.67 to 0.77) and OR 0.77 (95% CI 0.61 to 0.97). Occupancy above 90% of available beds was not associated with mechanical ventilation or noninvasive ventilation, but with high-flow oxygen therapy, OR 1.36 (95% CI 1.21 to 1.53). All measures of pressure on resources were associated with transfer to other hospitals, but none were associated with discharge at night, ICU mortality or 30-day mortality.\n\nPressure on ICU resources was associated with more invasive respiratory support, indicating that during these times, ICU resources were reserved for sicker patients.", "doi": "10.1097/EJA.0000000000001760", "pmid": "36156044", "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00003643-990000000-00037"}], "notes": [], "created": "2022-10-13T13:40:52.395Z", "modified": "2022-10-13T13:40:52.407Z"}, {"entity": "publication", "iuid": "1af31fe1dd4e4ce093745b83c68d4e4b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1af31fe1dd4e4ce093745b83c68d4e4b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1af31fe1dd4e4ce093745b83c68d4e4b"}}, "title": "A comparison of impact of comorbidities and demographics on 60-day mortality in ICU patients with COVID-19, sepsis and acute respiratory distress syndrome.", "authors": [{"family": "Ahlstr\u00f6m", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0001-9287-3607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0606fea9cd1048b99690f2e2823004ce.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Larsson", "given": "Ing-Marie", "initials": "I"}, {"family": "Strandberg", "given": "Gunnar", "initials": "G"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}], "type": "journal article", "published": "2022-09-20", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "12", "issue": "1", "pages": "15703"}, "abstract": "Severe Coronavirus disease 2019 (COVID-19) is associated with several pre-existing comorbidities and demographic factors. Similar factors are linked to critical sepsis and acute respiratory distress syndrome (ARDS). We hypothesized that age and comorbidities are more generically linked to critical illness mortality than a specific disease state. We used national databases to identify ICU patients and to retrieve comorbidities. The relative importance of risk factors for 60-day mortality was evaluated using the interaction with disease group (Sepsis, ARDS or COVID-19) in logistic regression models. We included 32,501 adult ICU patients. In the model on 60-day mortality in sepsis and COVID-19 there were significant interactions with disease group for age, sex and asthma. In the model on 60-day mortality in ARDS and COVID-19 significant interactions with cohort were found for acute disease severity, age and chronic renal failure. In conclusion, age and sex play particular roles in COVID-19 mortality during intensive care but the burden of comorbidity was similar between sepsis and COVID-19 and ARDS and COVID-19.", "doi": "10.1038/s41598-022-19539-0", "pmid": "36127433", "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-19539-0"}, {"db": "pmc", "key": "PMC9487845"}], "notes": [], "created": "2022-10-13T13:37:40.483Z", "modified": "2022-10-13T14:41:17.868Z"}, {"entity": "publication", "iuid": "17fb7d6b29a641868a32c5a8e7493ae5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/17fb7d6b29a641868a32c5a8e7493ae5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/17fb7d6b29a641868a32c5a8e7493ae5"}}, "title": "The amount of SARS-CoV-2 RNA in wastewater relates to the development of the pandemic and its burden on the health system.", "authors": [{"family": "Wang", "given": "Hao", "initials": "H"}, {"family": "Churqui", "given": "Marianela Patzi", "initials": "MP"}, {"family": "Tunovic", "given": "Timur", "initials": "T"}, {"family": "Enache", "given": "Lucica", "initials": "L"}, {"family": "Johansson", "given": "Anette", "initials": "A"}, {"family": "K\u00e4rmander", "given": "Ambj\u00f6rn", "initials": "A"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Dotevall", "given": "Leif", "initials": "L"}, {"family": "Brezicka", "given": "Thomas", "initials": "T"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Norder", "given": "Hel\u00e9ne", "initials": "H"}], "type": "journal article", "published": "2022-09-16", "journal": {"title": "iScience", "issn": "2589-0042", "volume": "25", "issue": "9", "pages": "105000", "issn-l": "2589-0042"}, "abstract": "Virus surveillance in wastewater can be a useful indicator of the development of the COVID-19 pandemic in communities. However, knowledge about how the amount of SARS-CoV-2 RNA in wastewater relates to different data on the burden on the health system is still limited. Herein, we monitored the amount of SARS-CoV-2 RNA and the spectrum of virus variants in weekly pooled wastewater samples for two years from mid-February 2020 and compared them with several clinical data. The two-year monitoring showed the weekly changes in the amount of viral RNA in wastewater preceded the hospital care needs for COVID-19 and the number of acute calls on adult acute respiratory distress by 1-2 weeks during the first three waves of COVID-19. Our study demonstrates that virus surveillance in wastewater can predict the development of a pandemic and its burden on the health system, regardless of society's test capacity and possibility of tracking infected cases.", "doi": "10.1016/j.isci.2022.105000", "pmid": "36035197", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(22)01272-X"}, {"db": "pmc", "key": "PMC9398557"}], "notes": [], "created": "2022-10-07T12:44:32.188Z", "modified": "2022-10-07T12:44:57.950Z"}, {"entity": "publication", "iuid": "198df304734544bd97b1dd4d65203aae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/198df304734544bd97b1dd4d65203aae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/198df304734544bd97b1dd4d65203aae"}}, "title": "Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination.", "authors": [{"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Cai", "given": "Curtis", "initials": "C"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Niessl", "given": "Julia", "initials": "J"}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Lange", "given": "Joshua", "initials": "J"}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Mielke", "given": "Stephan", "initials": "S"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "Vesterbacka", "given": "Jan", "initials": "J"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Perez-Potti", "given": "Andre", "initials": "A"}, {"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "M\u00fcller", "given": "Thomas R", "initials": "TR"}, {"family": "Boulouis", "given": "Caroline", "initials": "C"}, {"family": "Kammann", "given": "Tobias", "initials": "T"}, {"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Muvva", "given": "Jagadeeswara Rao", "initials": "JR"}, {"family": "Sobkowiak", "given": "Michal", "initials": "M"}, {"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "S\u00f6derdahl", "given": "Gunnar", "initials": "G"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Grifoni", "given": "Alba", "initials": "A"}, {"family": "Weiskopf", "given": "Daniela", "initials": "D"}, {"family": "Sette", "given": "Alessandro", "initials": "A"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}], "type": "journal article", "published": "2022-09-13", "journal": {"title": "Immunity", "issn": "1074-7613", "issn-l": null, "volume": "55", "issue": "9", "pages": "1732-1746.e5"}, "abstract": "Many immunocompromised patients mount suboptimal humoral immunity after SARS-CoV-2 mRNA vaccination. Here, we assessed the single-cell profile of SARS-CoV-2-specific T cells post-mRNA vaccination in healthy individuals and patients with various forms of immunodeficiencies. Impaired vaccine-induced cell-mediated immunity was observed in many immunocompromised patients, particularly in solid-organ transplant and chronic lymphocytic leukemia patients. Notably, individuals with an inherited lack of mature B cells, i.e., X-linked agammaglobulinemia (XLA) displayed highly functional spike-specific T cell responses. Single-cell RNA-sequencing further revealed that mRNA vaccination induced a broad functional spectrum of spike-specific CD4+ and CD8+ T cells in healthy individuals and patients with XLA. These responses were founded on polyclonal repertoires of CD4+ T cells and robust expansions of oligoclonal effector-memory CD45RA+ CD8+ T cells with stem-like characteristics. Collectively, our data provide the functional continuum of SARS-CoV-2-specific T cell responses post-mRNA vaccination, highlighting that cell-mediated immunity is of variable functional quality across immunodeficiency syndromes.", "doi": "10.1016/j.immuni.2022.07.005", "pmid": "35961317", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Research Area: Pandemic preparedness": null}, "xrefs": [{"db": "pmc", "key": "PMC9293955"}, {"db": "pii", "key": "S1074-7613(22)00338-7"}], "notes": [], "created": "2022-08-15T15:03:48.087Z", "modified": "2023-06-19T15:22:45.168Z"}, {"entity": "publication", "iuid": "914b9bc1bcef42d38359a1786dd84dcf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/914b9bc1bcef42d38359a1786dd84dcf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/914b9bc1bcef42d38359a1786dd84dcf"}}, "title": "Genetic and immunologic evaluation of children with inborn errors of immunity and severe or critical COVID-19.", "authors": [{"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Delavari", "given": "Samaneh", "initials": "S"}, {"family": "Landegren", "given": "Nils", "initials": "N"}, {"family": "Shokri", "given": "Sima", "initials": "S"}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Zuo", "given": "Fanglei", "initials": "F"}, {"family": "Hajebi", "given": "Reza", "initials": "R"}, {"family": "Abolnezhadian", "given": "Farhad", "initials": "F"}, {"family": "Iranparast", "given": "Sara", "initials": "S"}, {"family": "Modaresi", "given": "Mohammadreza", "initials": "M"}, {"family": "Vosughimotlagh", "given": "Ahmad", "initials": "A"}, {"family": "Salami", "given": "Fereshte", "initials": "F"}, {"family": "Aranda-Guill\u00e9n", "given": "Maribel", "initials": "M"}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A"}, {"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "S"}, {"family": "Zhang", "given": "Qian", "initials": "Q"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "J"}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}], "type": "journal article", "published": "2022-09-13", "journal": {"title": "J Allergy Clin Immunol", "issn": "1097-6825", "issn-l": "0091-6749", "volume": null, "issue": null, "pages": null}, "abstract": "Most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals are asymptomatic or only exhibit mild disease. In about 10% of cases, the infection leads to hypoxemic pneumonia, although it is much more rare in children.\r\n\r\nWe evaluated 31 young patients aged 0.5 to 19 years who had preexisting inborn errors of immunity (IEI) but lacked a molecular diagnosis and were later diagnosed with coronavirus disease 2019 (COVID-19) complications.\r\n\r\nGenetic evaluation by whole-exome sequencing was performed in all patients. SARS-CoV-2-specific antibodies, autoantibodies against type I IFN (IFN-I), and inflammatory factors in plasma were measured. We also reviewed COVID-19 disease severity/outcome in reported IEI patients.\r\n\r\nA potential genetic cause of the IEI was identified in 28 patients (90.3%), including mutations that may affect IFN signaling, T- and B-cell function, the inflammasome, and the complement system. From tested patients 65.5% had detectable virus-specific antibodies, and 6.8% had autoantibodies neutralizing IFN-I. Five patients (16.1%) fulfilled the diagnostic criteria of multisystem inflammatory syndrome in children. Eleven patients (35.4%) died of COVID-19 complications. All together, at least 381 IEI children with COVID-19 have been reported in the literature to date. Although many patients with asymptomatic or mild disease may not have been reported, severe presentation of COVID-19 was observed in 23.6% of the published cases, and the mortality rate was 8.7%.\r\n\r\nYoung patients with preexisting IEI may have higher mortality than children without IEI when infected with SARS-CoV-2. Elucidating the genetic basis of IEI patients with severe/critical COVID-19 may help to develop better strategies for prevention and treatment of severe COVID-19 disease and complications in pediatric patients.", "doi": "10.1016/j.jaci.2022.09.005", "pmid": "36113674", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "S0091-6749(22)01185-X"}, {"db": "pmc", "key": "PMC9472457"}], "notes": [], "created": "2022-10-13T13:32:35.129Z", "modified": "2022-10-13T13:34:58.395Z"}, {"entity": "publication", "iuid": "445377ec34e046d7a5d2375bd676828e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/445377ec34e046d7a5d2375bd676828e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/445377ec34e046d7a5d2375bd676828e"}}, "title": "COVID-19 is associated with bystander polyclonal autoreactive B cell activation as reflected by a broad autoantibody production, but none is linked to disease severity.", "authors": [{"family": "Jiang", "given": "Wei", "initials": "W", "orcid": "0000-0002-1374-053X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b3788374c8a4b83a5d94577fa1ff933.json"}}, {"family": "Johnson", "given": "Douglas", "initials": "D"}, {"family": "Adekunle", "given": "Ruth", "initials": "R"}, {"family": "Heather", "given": "Hughes", "initials": "H"}, {"family": "Xu", "given": "Wanli", "initials": "W"}, {"family": "Cong", "given": "Xiaomei", "initials": "X"}, {"family": "Wu", "given": "Xueling", "initials": "X"}, {"family": "Fan", "given": "Hongkuan", "initials": "H"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "L"}, {"family": "Robertson", "given": "Josefina", "initials": "J"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2022-09-10", "journal": {"title": "J Med Virol", "issn": "1096-9071", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Coronavirus disease 2019 (COVID-19) is associated with autoimmune features and autoantibody production in a small subset of the population. Pre-existing neutralizing antitype I interferons (IFNs) autoantibodies are related to the severity of COVID-19. Plasma levels of IgG and IgM against 12 viral antigens and 103 self-antigens were evaluated using an antibody protein array in patients with severe/critical or mild/moderate COVID-19 disease and uninfected controls. Patients exhibited increased IgGs against Severe acute respiratory syndrome coronavirus-2 proteins compared to controls, but no difference was observed in the two patient groups. 78% autoreactive IgGs and 93% autoreactive IgMs were increased in patients versus controls. There was no difference in the plasma levels of anti-type I IFN autoantibodies or neutralizing anti-type I IFN activity of plasma samples from the two patient groups. Increased anti-type I IFN IgGs were correlated with higher lymphocyte accounts, suggesting a role of nonpathogenic autoantibodies. Notably, among the 115 antibodies tested, only plasma levels of IgGs against human coronavirus (HCOV)-229E and HCOV-NL63 spike proteins were associated with mild disease outcome. COVID-19 was associated with a bystander polyclonal autoreactive B cell activation, but none of the autoantibody levels were linked to disease severity. Long-term humoral immunity against HCOV-22E and HCOV-NL63 spike protein was associated with mild disease outcome. Understanding the mechanism of life-threatening COVID-19 is critical to reducing mortality and morbidity.", "doi": "10.1002/jmv.28134", "pmid": "36086941", "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9538121"}], "notes": [], "created": "2022-10-13T13:27:53.034Z", "modified": "2022-10-13T14:41:54.606Z"}, {"entity": "publication", "iuid": "cfc18a5797b240c0920df270cb4586db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfc18a5797b240c0920df270cb4586db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfc18a5797b240c0920df270cb4586db"}}, "title": "Thrombosis with thrombocytopenia after AZD1222 (ChAdOx1 nCov-19) vaccination: Case characteristics and associations.", "authors": [{"family": "Laffan", "given": "Michael A", "initials": "MA"}, {"family": "Rees", "given": "Sue", "initials": "S"}, {"family": "Yadavalli", "given": "Madhavi", "initials": "M"}, {"family": "Ferstenberg", "given": "Lisa Beth", "initials": "LB"}, {"family": "Kumar Shankar", "given": "Nirmal", "initials": "N"}, {"family": "Medin", "given": "Jennie", "initials": "J"}, {"family": "Foskett", "given": "Nadia", "initials": "N"}, {"family": "Arnold", "given": "Matthew", "initials": "M"}, {"family": "Gomes da Silva", "given": "Hugo", "initials": "H"}, {"family": "Bhuyan", "given": "Prakash", "initials": "P"}, {"family": "Nord", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2022-09-09", "journal": {"title": "Vaccine", "issn": "1873-2518", "volume": "40", "issue": "38", "pages": "5585-5593", "issn-l": null}, "abstract": "Post-marketing surveillance for COVID-19 vaccines during the pandemic identified an extremely rare thrombosis with thrombocytopenia syndrome (TTS) reported post-vaccination, requiring further characterisation to improve diagnosis and management.\n\nWe searched the AstraZeneca Global Safety Database (through April 26, 2021) for cases with co-reported thrombocytopenia and thrombosis (using standardised MedDRA queries/high-level terms) following AZD1222 (ChAdOx1 nCoV-19). Cases were adjudicated by experts as 'typical','possible', 'no' or 'unknown' according to available TTS criteria. Additional confirmatory datasets (May 20-June 20, October 1-December 28) were evaluated.\n\nWe identified 573 reports, including 273 (47.6 %) 'typical' and 171 (29.8 %) 'possible' TTS cases. Of these 444 cases, 275 (61.9 %) were female, median age was 50.0 years (IQR: 38.0-60.0). Cerebral venous sinus thrombosis was reported in 196 (44.1 %) cases, splanchnic venous thrombosis in 65 (14.6 %) and thromboses at multiple sites in 119 (26.8 %). Median time to onset was 12.0 days (IQR: 9.0-15.0). Comparison with a pre-pandemic reference population indicated higher rates of autoimmune disorders (13.8 %, 4.4 %), previous heparin therapy (7.4 %, 1.2 %), history of thrombosis (5.5 %, 1.4 %), and immune thrombocytopenia (6.1 %, 0.2 %). Fatality rate was 22.2 % (127/573) overall and 23.6 % (105/444) in 'typical'/'possible' TTS, which decreased from 39.0 % (60/154) in February/March to 15.5 % (45/290) in April. Overall patterns were similar in confirmatory datasets.\n\nThe reporting rate of 'typical'/'possible' TTS post first-dose vaccination in this dataset is 7.5 per million vaccinated persons; few cases were reported after subsequent doses, including booster doses. Peak reporting coincided with media-driven attention. Medical history differences versus a reference population indicate potentially unidentified risk factors. The decreasing fatality rate correlates with increasing awareness and publication of diagnostic/treatment guidelines. Adjudication was hindered by unreported parameters, and an algorithm was developed to classify potential TTS cases; comprehensive reporting could help further improve definition and management of this extremely rare syndrome.", "doi": "10.1016/j.vaccine.2022.08.007", "pmid": "35989136", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(22)00964-1"}, {"db": "pmc", "key": "PMC9388294"}], "notes": [], "created": "2022-09-12T18:49:59.431Z", "modified": "2022-09-12T18:50:20.934Z"}, {"entity": "publication", "iuid": "98c4fad1a2c54587ab229be91b562c70", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/98c4fad1a2c54587ab229be91b562c70.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/98c4fad1a2c54587ab229be91b562c70"}}, "title": "Sialic Acid and Fucose Residues on the SARS-CoV-2 Receptor-Binding Domain Modulate IgG Antibody Reactivity.", "authors": [{"family": "Samuelsson", "given": "Ebba", "initials": "E"}, {"family": "Mirgorodskaya", "given": "Ekaterina", "initials": "E"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "B\u00e4ckstr\u00f6m", "given": "Malin", "initials": "M"}, {"family": "Liljeqvist", "given": "Jan-\u00c5ke", "initials": "J\u00c5"}, {"family": "Nord\u00e9n", "given": "Rickard", "initials": "R", "orcid": "0000-0002-3866-7228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/270f5cf52d6544a78dc4bde1bf1e97a2.json"}}], "type": "journal article", "published": "2022-09-09", "journal": {"title": "ACS Infect Dis", "issn": "2373-8227", "volume": "8", "issue": "9", "pages": "1883-1893", "issn-l": null}, "abstract": "The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is a conserved domain and a target for neutralizing antibodies. We defined the carbohydrate content of the recombinant RBD produced in different mammalian cells. We found a higher degree of complex-type N-linked glycans, with less sialylation and more fucosylation, when the RBD was produced in human embryonic kidney cells compared to the same protein produced in Chinese hamster ovary cells. The carbohydrates on the RBD proteins were enzymatically modulated, and the effect on antibody reactivity was evaluated with serum samples from SARS-CoV-2 positive patients. Removal of all carbohydrates diminished antibody reactivity, while removal of only sialic acids or terminal fucoses improved the reactivity. The RBD produced in Lec3.2.8.1-cells, which generate carbohydrate structures devoid of sialic acids and with reduced fucose content, exhibited enhanced antibody reactivity, verifying the importance of these specific monosaccharides. The results can be of importance for the design of future vaccine candidates, indicating that it is possible to enhance the immunogenicity of recombinant viral proteins.", "doi": "10.1021/acsinfecdis.2c00155", "pmid": "35980012", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:42:27.556Z", "modified": "2022-09-12T18:42:50.047Z"}, {"entity": "publication", "iuid": "968c86731eb34291987dde45dbc6e055", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/968c86731eb34291987dde45dbc6e055.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/968c86731eb34291987dde45dbc6e055"}}, "title": "Recovering from COVID-19 - A Process Characterised by Uncertainty: A Qualitative study.", "authors": [{"family": "Engwall", "given": "Marie", "initials": "M"}, {"family": "T\u00f6rnbom", "given": "Karin", "initials": "K"}, {"family": "Persson", "given": "Hanna C", "initials": "HC"}, {"family": "Palstam", "given": "Annie", "initials": "A"}], "type": "journal article", "published": "2022-09-09", "journal": {"title": "J Rehabil Med", "issn": "1651-2081", "volume": "54", "pages": "jrm00326", "issn-l": null}, "abstract": "To obtain a deeper understanding of the lived experiences of patients with COVID-19, the recovery process and consequences for everyday life 6 months after hospital discharge.\n\nAn explorative qualitative study using individual interviews.\n\nA purposive sampling was applied to recruit persons who had received inpatient hospital care, were discharged approximately 6 months previously, were of working age and had persistent self-reported symptoms at a 3-month follow-up appointment.\n\nSemi-structured interviews were conducted with 15 participants (10 men, 5 women), which were then transcribed and analysed with inductive thematic analysis.\n\nThree themes were identified: \"Status of recovery - two steps forward, one step back\", \"Remaining symptoms caused limitations in everyday life\" and \"Strategies for recovery\". Participants indicated the recovery process through 6 months after discharge was a challenging road, often involving setbacks. A wide range of persistent, fluctuating, or new symptoms negatively impacted many areas of daily life, with fatigue and lack of energy being especially prominent. Participants used a variety of strategies to cope and recover.\n\nThis study increases our knowledge of the lived experiences of COVID-19 based individual experiences. Unexpected symptoms in the recovery process were described and not always possible to forecast.", "doi": "10.2340/jrm.v54.2739", "pmid": "35976769", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:39:02.356Z", "modified": "2022-09-12T18:39:02.362Z"}, {"entity": "publication", "iuid": "79254181a0ab4b0ca26323a6deb65af0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79254181a0ab4b0ca26323a6deb65af0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79254181a0ab4b0ca26323a6deb65af0"}}, "title": "Monitoring of the SARS-CoV-2 Omicron BA.1/BA.2 lineage transition in the Swedish population reveals increased viral RNA levels in BA.2 cases.", "authors": [{"family": "Lentini", "given": "Antonio", "initials": "A"}, {"family": "Pereira", "given": "Antonio", "initials": "A"}, {"family": "Winqvist", "given": "Ola", "initials": "O"}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-7021-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9eef54f4e0534805b173cfae62a75d55.json"}}], "type": "case reports", "published": "2022-09-09", "journal": {"title": "Med (N Y)", "issn": "2666-6340", "issn-l": null, "volume": "3", "issue": "9", "pages": "636-643.e4"}, "abstract": "Throughout the SARS-CoV-2 pandemic, multiple waves of variants of concern have swept across populations, leading to a chain of new and yet more contagious variants dominating COVID-19 cases. Here, we tracked the remarkably rapid shift from Omicron BA.1 to BA.2 sublineage dominance in the Swedish population in early 2022 at a day-by-day basis.\n\nUsing a custom SARS-CoV-2 Omicron BA.1 lineage-typing RT-PCR assay, we analyzed 174,933 clinical upper airway samples collected during January to March 2022.\n\nOur study demonstrates the feasibility and reliability of parallel lineage assignment of select variants at population scale, tracking the dominant sublineage transition from BA.1 to BA.2 at day-to-day resolution and uncovering nearly 2-fold higher levels of viral RNA in cases infected with Omicron BA.2 relative to BA.1.\n\nOur data provide unique insights into the Omicron BA.1 to BA.2 transition that occurred in Sweden during early 2022, and later, across the world. This may help to understand the increased transmissibility of the BA.2 variant.", "doi": "10.1016/j.medj.2022.07.007", "pmid": "35981541", "labels": {"Category: Health": null, "Category: Omicron VoC": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9359497"}, {"db": "pii", "key": "S2666-6340(22)00317-8"}], "notes": [], "created": "2022-03-28T10:31:50.830Z", "modified": "2023-06-19T15:01:12.299Z"}, {"entity": "publication", "iuid": "c73f45508d7b4fb995f7ceccefa7a93d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c73f45508d7b4fb995f7ceccefa7a93d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c73f45508d7b4fb995f7ceccefa7a93d"}}, "title": "Back to life: Is it possible to be myself again? A qualitative study with persons initially hospitalised due to COVID-19.", "authors": [{"family": "T\u00f6rnbom", "given": "Karin", "initials": "K"}, {"family": "Engwall", "given": "Marie", "initials": "M"}, {"family": "Persson", "given": "Hanna C", "initials": "HC"}, {"family": "Palstam", "given": "Annie", "initials": "A"}], "type": "journal article", "published": "2022-09-09", "journal": {"title": "J Rehabil Med", "issn": "1651-2081", "volume": "54", "pages": "jrm00327", "issn-l": null}, "abstract": "To gain a deeper understanding of the lived experiences of patients with COVID-19, regarding rehabilitation, work and social life 6 months after hospital discharge.\n\nAn explorative qualitative study with individual interviews.\n\nPatients of working age with persistent self-reported symptoms at a 3-month follow-up who had received inpatient hospital care with discharge approximately 6 months previously were purposively sampled.\n\nSemi-structured interviews were performed with 10 men and 5 women. The interviews were transcribed verbatim and analysed with inductive thematic analysis.\n\nFour themes were identified: \"Social support - crucial, but decreased over time\", \"Varying needs of, and access to, rehabilitation\", \"Returning to work after COVID-19 - crucial for future prospects\" and \"An overwhelming experience that essentially changed one's personality\".\n\nRehabilitation provided participants with the valuable tools for recovery, giving them hope for future recovery. Support from next of kin was highly valued, creating stronger family bonds. A new meaning and greater appreciation of life was expressed.", "doi": "10.2340/jrm.v54.2742", "pmid": "35976766", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:38:30.988Z", "modified": "2022-09-12T18:38:30.993Z"}, {"entity": "publication", "iuid": "3468fd2046304320ab7fc4fbe3c66355", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3468fd2046304320ab7fc4fbe3c66355.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3468fd2046304320ab7fc4fbe3c66355"}}, "title": "Spatio-temporal predictions of COVID-19 test positivity in Uppsala County, Sweden: a comparative approach.", "authors": [{"family": "van Zoest", "given": "Vera", "initials": "V", "orcid": "0000-0002-3017-0874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72aee535dc8c45478a4cf678e01d2421.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G"}, {"family": "Menzel", "given": "Uwe", "initials": "U"}, {"family": "Wigren", "given": "Anders", "initials": "A"}, {"family": "Kennedy", "given": "Beatrice", "initials": "B", "orcid": "0000-0002-0066-4814", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d3a346caa424c4dad653097b2518efb.json"}}, {"family": "Martinell", "given": "Mats", "initials": "M"}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f34c0d3602439abe6096293c7c732d.json"}}], "type": "journal article", "published": "2022-09-07", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "15176", "issn-l": "2045-2322"}, "abstract": "Previous spatio-temporal COVID-19 prediction models have focused on the prediction of subsequent number of cases, and have shown varying accuracy and lack of high geographical resolution. We aimed to predict trends in COVID-19 test positivity, an important marker for planning local testing capacity and accessibility. We included a full year of information (June 29, 2020-July 4, 2021) with both direct and indirect indicators of transmission, e.g. mobility data, number of calls to the national healthcare advice line and vaccination coverage from Uppsala County, Sweden, as potential predictors. We developed four models for a 1-week-window, based on gradient boosting (GB), random forest (RF), autoregressive integrated moving average (ARIMA) and integrated nested laplace approximations (INLA). Three of the models (GB, RF and INLA) outperformed the na\u00efve baseline model after data from a full pandemic wave became available and demonstrated moderate accuracy. An ensemble model of these three models slightly improved the average root mean square error to 0.039 compared to 0.040 for GB, RF and INLA, 0.055 for ARIMA and 0.046 for the na\u00efve model. Our findings indicate that the collection of a wide variety of data can contribute to spatio-temporal predictions of COVID-19 test positivity.", "doi": "10.1038/s41598-022-19155-y", "pmid": "36071066", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-19155-y"}, {"db": "pmc", "key": "PMC9450842"}], "notes": [], "created": "2022-10-13T13:26:00.407Z", "modified": "2022-10-13T13:26:21.845Z"}, {"entity": "publication", "iuid": "7e7de2c58ea7451fa5926a0741e07232", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e7de2c58ea7451fa5926a0741e07232.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e7de2c58ea7451fa5926a0741e07232"}}, "title": "Protection against SARS-CoV-2 transmission by a parenteral prime-Intranasal boost vaccine strategy.", "authors": [{"family": "Christensen", "given": "Dennis", "initials": "D"}, {"family": "Polacek", "given": "Charlotta", "initials": "C"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Moliner-Morro", "given": "Ainhoa", "initials": "A"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Hartmann", "given": "Katrine Top", "initials": "KT"}, {"family": "Jensen", "given": "Henrik Elvang", "initials": "HE"}, {"family": "Jungersen", "given": "Gregers", "initials": "G"}, {"family": "Illigen", "given": "Kristin", "initials": "K"}, {"family": "Isling", "given": "Louise Krag", "initials": "LK"}, {"family": "Jensen", "given": "Rune Fledelius", "initials": "RF"}, {"family": "Hansen", "given": "Julia Sid", "initials": "JS"}, {"family": "Rosenkrands", "given": "Ida", "initials": "I"}, {"family": "Fernandez-Antunez", "given": "Carlota", "initials": "C"}, {"family": "Ramirez", "given": "Santseharay", "initials": "S"}, {"family": "Follmann", "given": "Frank", "initials": "F"}, {"family": "Bukh", "given": "Jens", "initials": "J"}, {"family": "Pedersen", "given": "Gabriel Kristian", "initials": "GK"}], "type": "journal article", "published": "2022-09-05", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": null, "issue": null, "pages": "104248"}, "abstract": "Licensed vaccines against SARS-CoV-2 effectively protect against severe disease, but display incomplete protection against virus transmission. Mucosal vaccines providing immune responses in the upper airways are one strategy to protect against transmission.\r\n\r\nWe administered Spike HexaPro trimer formulated in a cationic liposomal adjuvant as a parenteral (subcutaneous - s.c.) prime - intranasal boost regimen to elicit airway mucosal immune responses and evaluated this in a Syrian hamster model of virus transmission.\r\n\r\nParenteral prime - intranasal boost elicited high-magnitude serum neutralizing antibody responses and IgA responses in the upper respiratory tract. The vaccine strategy protected against virus in the lower airways and lung pathology, but virus could still be detected in the upper airways. Despite this, the parenteral prime - intranasal booster vaccine effectively protected against onward SARS-CoV-2 transmission.\r\n\r\nThis study suggests that parenteral-prime mucosal boost is an effective strategy for protecting against SARS-CoV-2 infection and highlights that protection against virus transmission may be obtained despite incomplete clearance of virus from the upper respiratory tract. It should be noted that protection against onward transmission was not compared to standard parenteral prime-boost, which should be a focus for future studies.\r\n\r\nThis work was primarily supported by the European Union Horizon 2020 research and innovation program under grant agreement no. 101003653.", "doi": "10.1016/j.ebiom.2022.104248", "pmid": "36088218", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "S2352-3964(22)00430-3"}], "notes": [], "created": "2022-09-12T19:32:33.868Z", "modified": "2022-09-12T19:33:52.615Z"}, {"entity": "publication", "iuid": "d20e1200b5a14722a7cf1ef691ea52dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d20e1200b5a14722a7cf1ef691ea52dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d20e1200b5a14722a7cf1ef691ea52dd"}}, "title": "Cross-direct effects in settings with two mediators.", "authors": [{"family": "Gabriel", "given": "Erin E", "initials": "EE", "orcid": "0000-0002-0504-8404", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a390da0ea8a54bf6a7eec1aec5959ba2.json"}}, {"family": "Sj\u00f6lander", "given": "Arvid", "initials": "A", "orcid": "0000-0001-5226-6685", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9de77f267804d99b19c0e47237cf413.json"}}, {"family": "Follmann", "given": "Dean", "initials": "D"}, {"family": "Sachs", "given": "Michael C", "initials": "MC", "orcid": "0000-0002-1279-8676", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e1b0576ba84040bb393a4ecee4cb3b.json"}}], "type": "journal article", "published": "2022-09-02", "journal": {"title": "Biostatistics", "issn": "1468-4357", "issn-l": null}, "abstract": "When multiple mediators are present, there are additional effects that may be of interest beyond the well-known natural (NDE) and controlled direct effects (CDE). These effects cross the type of control on the mediators, setting one to a constant level and one to its natural level, which differs across subjects. We introduce five such estimands for the cross-CDE and -NDE when two mediators are measured. We consider both the scenario where one mediator is influenced by the other, referred to as sequential mediators, and the scenario where the mediators do not influence each other. Such estimands may be of interest in immunology, as we discuss in relation to measured immunological responses to SARS-CoV-2 vaccination. We provide identifying expressions for the estimands in observational settings where there is no residual confounding, and where intervention, outcome, and mediators are of arbitrary type. We further provide tight symbolic bounds for the estimands in randomized settings where there may be residual confounding of the outcome and mediator relationship and all measured variables are binary.", "doi": "10.1093/biostatistics/kxac037", "pmid": "36050911", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6684013"}], "notes": [], "created": "2022-10-13T13:18:27.085Z", "modified": "2022-10-13T13:18:52.493Z"}, {"entity": "publication", "iuid": "c43434d2bca64fc8af96906e2c5fbccf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c43434d2bca64fc8af96906e2c5fbccf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c43434d2bca64fc8af96906e2c5fbccf"}}, "title": "\"Role of kidney function and concentrations of BAFF, sPD-L1 and sCD25 on mortality in hospitalized patients with COVID-19\".", "authors": [{"family": "Mansouri", "given": "Ladan", "initials": "L"}, {"family": "Sendic", "given": "Senka", "initials": "S"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Jacobson", "given": "Stefan H", "initials": "SH"}, {"family": "Lundahl", "given": "Joachim", "initials": "J"}], "type": "journal article", "published": "2022-09-02", "journal": {"title": "BMC Nephrol", "issn": "1471-2369", "volume": "23", "issue": "1", "pages": "299", "issn-l": null}, "abstract": "Chronic kidney disease (CKD) is a recognized risk factor for severe complications in COVID-19. Our objective was to analyze the association between kidney function / T and B lymphocyte modulatory factors and risk of mortality in COVID-19 patients.\n\nIn-hospital and 30-day mortality were analyzed in COVID-19 patients (n = 110). Plasma levels of selected T and B cell modulators were analyzed and correlated to mortality risk. A subgroup of sex- and eGFR-matched COVID-19 patients was compared to CKD patients without infection and healthy subjects.\n\nCOVID-19 patients who died in hospital and within 30 days had significantly higher BAFF and sCD25 plasma levels than survivors. In logistic regression models patients with high BAFF, sCD25 and sPD-L1 levels had significantly higher risk of both in-hospital and 30-day mortality while there was no association to eGFR. In the subgroup analysis, a higher level of BAFF, IFN-\u03b1, sCD25, sPD-L1 and a lower level of sCD40L was observed in COVID-19 patients compared to the CKD group with corresponding kidney function.\n\nWe demonstrate that kidney function and concentrations of BAFF, sCD25 and PD-L1, independent of previously recognized risk factors; age, male gender, and leukocytosis are associated with risk of in-hospital and 30-day mortality in patients with COVID-19. These data indicate the significance of adaptive immune system modulators in COVID-19 and motivate further analysis to identify new potential prognostic and therapeutic approaches.", "doi": "10.1186/s12882-022-02924-2", "pmid": "36056305", "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12882-022-02924-2"}, {"db": "pmc", "key": "PMC9438228"}], "notes": [], "created": "2022-10-13T13:22:06.214Z", "modified": "2022-10-13T13:22:06.226Z"}, {"entity": "publication", "iuid": "023f130b0f164fcfb08ed1472c1bee2d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/023f130b0f164fcfb08ed1472c1bee2d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/023f130b0f164fcfb08ed1472c1bee2d"}}, "title": "International Perspectives on the Impact of the COVID-19 Pandemic on Adherence to Prescribed Dual Antiplatelet Therapy: A Window Into Acute Cardiovascular Care.", "authors": [{"family": "Pollack", "given": "Charles V", "initials": "CV"}, {"family": "Steg", "given": "P Gabriel", "initials": "PG"}, {"family": "James", "given": "Stefan", "initials": "S"}, {"family": "Jolly", "given": "Sanjit", "initials": "S"}, {"family": "Kosiborod", "given": "Mikhail", "initials": "M"}, {"family": "Bonaca", "given": "Marc P", "initials": "MP"}], "type": "journal article", "published": "2022-09-01", "journal": {"title": "Crit Pathw Cardiol", "issn": "1535-2811", "volume": "21", "issue": "3", "pages": "114-122", "issn-l": null}, "abstract": "An international panel of expert clinicians and researchers in acute cardiac care was convened to review, describe, and contextualize their varied experiences delivering care and maintaining ongoing research during the first year of the COVID-19 pandemic and beyond. A proposed perspective from which care and outcomes could be viewed was the possibility that without routine follow-up and as-accustomed interactions with their care team, patients at risk of acute atherothrombotic events might be less adherent to prescribed antiplatelet medications. This might be manifested by more emergency coronary events or by an increased (and perhaps unidentifiable) incidence of out-of-hospital cardiovascular deaths related to patient anxiety about presenting to hospital during the pandemic. The experiences of the panel members were similar in many regards, which identified opportunities for improvement in cardiac care the next time there is a substantial disruption of usual practice. Regardless of geography or payor system, there was an identified need for better remote care platforms; but stronger infrastructure and consumer facility with remote care technology, improved provider-patient communication to help ensure adherence to primary and secondary prevention medications, and longer-term prescription fills and no-hassle refills on such medications. Profound disruptions in acute cardiovascular research highlighted the need for redundancy or back-up planning for teams engaged in time-sensitive research, to ensure both continuity of protocols and patient safety.", "doi": "10.1097/HPC.0000000000000292", "pmid": "35994719", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00132577-202209000-00002"}, {"db": "pmc", "key": "PMC9389943"}], "notes": [], "created": "2022-09-12T19:00:10.930Z", "modified": "2022-09-12T19:00:21.855Z"}, {"entity": "publication", "iuid": "1863b4966cc3452b824b91225a55eed6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1863b4966cc3452b824b91225a55eed6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1863b4966cc3452b824b91225a55eed6"}}, "title": "High-dimensional multinomial multiclass severity scoring of COVID-19 pneumonia using CT radiomics features and machine learning algorithms.", "authors": [{"family": "Shiri", "given": "Isaac", "initials": "I"}, {"family": "Mostafaei", "given": "Shayan", "initials": "S"}, {"family": "Haddadi Avval", "given": "Atlas", "initials": "A"}, {"family": "Salimi", "given": "Yazdan", "initials": "Y"}, {"family": "Sanaat", "given": "Amirhossein", "initials": "A"}, {"family": "Akhavanallaf", "given": "Azadeh", "initials": "A"}, {"family": "Arabi", "given": "Hossein", "initials": "H"}, {"family": "Rahmim", "given": "Arman", "initials": "A"}, {"family": "Zaidi", "given": "Habib", "initials": "H"}], "type": "journal article", "published": "2022-09-01", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "14817", "issn-l": "2045-2322"}, "abstract": "We aimed to construct a prediction model based on computed tomography (CT) radiomics features to classify COVID-19 patients into severe-, moderate-, mild-, and non-pneumonic. A total of 1110 patients were studied from a publicly available dataset with 4-class severity scoring performed by a radiologist (based on CT images and clinical features). The entire lungs were segmented and followed by resizing, bin discretization and radiomic features extraction. We utilized two feature selection algorithms, namely bagging random forest (BRF) and multivariate adaptive regression splines (MARS), each coupled to a classifier, namely multinomial logistic regression (MLR), to construct multiclass classification models. The dataset was divided into 50% (555 samples), 20% (223 samples), and 30% (332 samples) for training, validation, and untouched test datasets, respectively. Subsequently, nested cross-validation was performed on train/validation to select the features and tune the models. All predictive power indices were reported based on the testing set. The performance of multi-class models was assessed using precision, recall, F1-score, and accuracy based on the 4 \u00d7 4 confusion matrices. In addition, the areas under the receiver operating characteristic curves (AUCs) for multi-class classifications were calculated and compared for both models. Using BRF, 23 radiomic features were selected, 11 from first-order, 9 from GLCM, 1 GLRLM, 1 from GLDM, and 1 from shape. Ten features were selected using the MARS algorithm, namely 3 from first-order, 1 from GLDM, 1 from GLRLM, 1 from GLSZM, 1 from shape, and 3 from GLCM features. The mean absolute deviation, skewness, and variance from first-order and flatness from shape, and cluster prominence from GLCM features and Gray Level Non Uniformity Normalize from GLRLM were selected by both BRF and MARS algorithms. All selected features by BRF or MARS were significantly associated with four-class outcomes as assessed within MLR (All p values < 0.05). BRF + MLR and MARS + MLR resulted in pseudo-R2 prediction performances of 0.305 and 0.253, respectively. Meanwhile, there was a significant difference between the feature selection models when using a likelihood ratio test (p value = 0.046). Based on confusion matrices for BRF + MLR and MARS + MLR algorithms, the precision was 0.856 and 0.728, the recall was 0.852 and 0.722, whereas the accuracy was 0.921 and 0.861, respectively. AUCs (95% CI) for multi-class classification were 0.846 (0.805-0.887) and 0.807 (0.752-0.861) for BRF + MLR and MARS + MLR algorithms, respectively. Our models based on the utilization of radiomic features, coupled with machine learning were able to accurately classify patients according to the severity of pneumonia, thus highlighting the potential of this emerging paradigm in the prognostication and management of COVID-19 patients.", "doi": "10.1038/s41598-022-18994-z", "pmid": "36050434", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-18994-z"}, {"db": "pmc", "key": "PMC9437017"}], "notes": [], "created": "2022-10-13T13:07:03.780Z", "modified": "2022-10-13T13:07:03.796Z"}, {"entity": "publication", "iuid": "86c2b35ac05c4a20a212e1670b3e12c4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86c2b35ac05c4a20a212e1670b3e12c4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86c2b35ac05c4a20a212e1670b3e12c4"}}, "title": "Decreased renal perfusion during acute kidney injury in critical COVID-19 assessed by magnetic resonance imaging: a prospective case control study.", "authors": [{"family": "Luther", "given": "Tomas", "initials": "T"}, {"family": "Eckerbom", "given": "Per", "initials": "P"}, {"family": "Cox", "given": "Eleanor", "initials": "E"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "B\u00fclow", "given": "Sara", "initials": "S"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Torrente", "given": "Francisco Martinez", "initials": "FM"}, {"family": "Weis", "given": "Jan", "initials": "J"}, {"family": "Palm", "given": "Fredrik", "initials": "F"}, {"family": "Francis", "given": "Susan", "initials": "S"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Liss", "given": "Per", "initials": "P"}], "type": "clinical trial", "published": "2022-09-01", "journal": {"title": "Crit Care", "issn": "1466-609X", "issn-l": "1364-8535", "volume": "26", "issue": "1", "pages": "262"}, "abstract": "Renal hypoperfusion has been suggested to contribute to the development of acute kidney injury (AKI) in critical COVID-19. However, limited data exist to support this. We aim to investigate the differences in renal perfusion, oxygenation and water diffusion using multiparametric magnetic resonance imaging in critically ill COVID-19 patients with and without AKI.\r\n\r\nA prospective case-control study where patients without prior kidney disease treated in intensive care for respiratory failure due to COVID-19 were examined. Kidney Disease: Improving Global Outcomes Creatinine criteria were used for group allocation. Main comparisons were tested using Mann-Whitney U test.\r\n\r\nNineteen patients were examined, ten with AKI and nine without AKI. Patients with AKI were examined in median 1 [0-2] day after criteria fulfillment. Age and baseline Plasma-Creatinine were similar in both groups. Total renal blood flow was lower in patients with AKI compared with patients without (median 645 quartile range [423-753] vs. 859 [746-920] ml/min, p = 0.037). Regional perfusion was reduced in both cortex (76 [51-112] vs. 146 [123-169] ml/100 g/min, p = 0.015) and medulla (28 [18-47] vs. 47 [38-73] ml/100 g/min, p = 0.03). Renal venous saturation was similar in both groups (72% [64-75] vs. 72% [63-84], ns.), as was regional oxygenation (R2*) in cortex (17 [16-19] vs. 17 [16-18] 1/s, ns.) and medulla (29 [24-39] vs. 27 [23-29] 1/s, ns.).\r\n\r\nIn critically ill COVID-19 patients with AKI, the total, cortical and medullary renal blood flows were reduced compared with similar patients without AKI, whereas no differences in renal oxygenation were demonstrable in this setting. Trial registration ClinicalTrials ID: NCT02765191 , registered May 6 2014 and updated May 7 2020.", "doi": "10.1186/s13054-022-04132-8", "pmid": "36050748", "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: VR": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-022-04132-8"}, {"db": "pmc", "key": "PMC9434518"}, {"db": "ClinicalTrials.gov", "key": "NCT02765191"}], "notes": [], "created": "2022-10-13T13:09:07.211Z", "modified": "2022-10-13T13:12:09.772Z"}, {"entity": "publication", "iuid": "cd676674860e43b297b2ffd3e77406b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd676674860e43b297b2ffd3e77406b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd676674860e43b297b2ffd3e77406b0"}}, "title": "When ethnographic work turns into distant screen visits: A note on flexible inflexibility during the COVID-19 pandemic.", "authors": [{"family": "Sandberg", "given": "Helena", "initials": "H"}, {"family": "Sundin", "given": "Ebba", "initials": "E", "orcid": "0000-0001-8712-7159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/55da76954579410d8b8c795429f03149.json"}}, {"family": "Sj\u00f6berg", "given": "Ulrika", "initials": "U"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Contemp Issues Early Child", "issn": "1463-9491", "issn-l": null, "volume": "23", "issue": "3", "pages": "361-365"}, "abstract": "This colloquium shares experiences from doing ethnographic fieldwork with young children and the challenges that followed due to the COVID-19 pandemic. The project DIGIKIDS Sweden has its focus on very young children (birth to three years) and their engagement with digital media technologies in their homes. The pandemic put the project on hold, but in the families where the fieldwork had already started, the authors decided to change the methods of data collection. Digital screen visits were introduced and, at first, this seemed to be flexible, and they adjusted to the new environment. At the same time, this flexibility also became an inflexible experience due to the use of technology.", "doi": "10.1177/14639491221107361", "pmid": "37520115", "labels": {"Funder: VR": null, "Category: Other": null, "Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC9194497"}, {"db": "pii", "key": "10.1177_14639491221107361"}], "notes": [], "created": "2023-10-04T12:12:41.646Z", "modified": "2023-10-04T13:32:54.390Z"}, {"entity": "publication", "iuid": "70ac7e22db0848d588ed605cd740756d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70ac7e22db0848d588ed605cd740756d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70ac7e22db0848d588ed605cd740756d"}}, "title": "The effect of different degrees of lockdown and self-identified gender on anxiety, depression and suicidality during the COVID-19 pandemic: Data from the international COMET-G study.", "authors": [{"family": "Fountoulakis", "given": "Konstantinos N", "initials": "KN"}, {"family": "Karakatsoulis", "given": "Grigorios N", "initials": "GN"}, {"family": "Abraham", "given": "Seri", "initials": "S"}, {"family": "Adorjan", "given": "Kristina", "initials": "K"}, {"family": "Ahmed", "given": "Helal Uddin", "initials": "HU"}, {"family": "Alarc\u00f3n", "given": "Renato D", "initials": "RD"}, {"family": "Arai", "given": "Kiyomi", "initials": "K"}, {"family": "Auwal", "given": "Sani Salihu", "initials": "SS"}, {"family": "Berk", "given": "Michael", "initials": "M"}, {"family": "Bjedov", "given": "Sarah", "initials": "S"}, {"family": "Bobes", "given": "Julio", "initials": "J"}, {"family": "Bobes-Bascaran", "given": "Teresa", "initials": "T"}, {"family": "Bourgin-Duchesnay", "given": "Julie", "initials": "J"}, {"family": "Bredicean", "given": "Cristina Ana", "initials": "CA"}, {"family": "Bukelskis", "given": "Laurynas", "initials": "L"}, {"family": "Burkadze", "given": "Akaki", "initials": "A"}, {"family": "Abud", "given": "Indira Indiana Cabrera", "initials": "IIC"}, {"family": "Castilla-Puentes", "given": "Ruby", "initials": "R"}, {"family": "Cetkovich", "given": "Marcelo", "initials": "M"}, {"family": "Colon-Rivera", "given": "Hector", "initials": "H"}, {"family": "Corral", "given": "Ricardo", "initials": "R"}, {"family": "Cortez-Vergara", "given": "Carla", "initials": "C"}, {"family": "Crepin", "given": "Piirika", "initials": "P"}, {"family": "De Berardis", "given": "Domenico", "initials": "D"}, {"family": "Delgado", "given": "Sergio Zamora", "initials": "SZ"}, {"family": "De Lucena", "given": "David", "initials": "D"}, {"family": "De Sousa", "given": "Avinash", "initials": "A"}, {"family": "Stefano", "given": "Ramona Di", "initials": "RD"}, {"family": "Dodd", "given": "Seetal", "initials": "S"}, {"family": "Elek", "given": "Livia Priyanka", "initials": "LP"}, {"family": "Elissa", "given": "Anna", "initials": "A"}, {"family": "Erdelyi-Hamza", "given": "Berta", "initials": "B"}, {"family": "Erzin", "given": "Gamze", "initials": "G"}, {"family": "Etchevers", "given": "Martin J", "initials": "MJ"}, {"family": "Falkai", "given": "Peter", "initials": "P"}, {"family": "Farcas", "given": "Adriana", "initials": "A"}, {"family": "Fedotov", "given": "Ilya", "initials": "I"}, {"family": "Filatova", "given": "Viktoriia", "initials": "V"}, {"family": "Fountoulakis", "given": "Nikolaos K", "initials": "NK"}, {"family": "Frankova", "given": "Iryna", "initials": "I"}, {"family": "Franza", "given": "Francesco", "initials": "F"}, {"family": "Frias", "given": "Pedro", "initials": "P"}, {"family": "Galako", "given": "Tatiana", "initials": "T"}, {"family": "Garay", "given": "Cristian J", "initials": "CJ"}, {"family": "Garcia-\u00c1lvarez", "given": "Leticia", "initials": "L"}, {"family": "Garc\u00eda-Portilla", "given": "Maria Paz", "initials": "MP"}, {"family": "Gonda", "given": "Xenia", "initials": "X"}, {"family": "Gondek", "given": "Tomasz M", "initials": "TM"}, {"family": "Gonz\u00e1lez", "given": "Daniela Morera", "initials": "DM"}, {"family": "Gould", "given": "Hilary", "initials": "H"}, {"family": "Grandinetti", "given": "Paolo", "initials": "P"}, {"family": "Grau", "given": "Arturo", "initials": "A"}, {"family": "Groudeva", "given": "Violeta", "initials": "V"}, {"family": "Hagin", "given": "Michal", "initials": "M"}, {"family": "Harada", "given": "Takayuki", "initials": "T"}, {"family": "Hasan", "given": "Tasdik M", "initials": "TM"}, {"family": "Hashim", "given": "Nurul Azreen", "initials": "NA"}, {"family": "Hilbig", "given": "Jan", "initials": "J"}, {"family": "Hossain", "given": "Sahadat", "initials": "S"}, {"family": "Iakimova", "given": "Rossitza", "initials": "R"}, {"family": "Ibrahim", "given": "Mona", "initials": "M"}, {"family": "Iftene", "given": "Felicia", "initials": "F"}, {"family": "Ignatenko", "given": "Yulia", "initials": "Y"}, {"family": "Irarrazaval", "given": "Matias", "initials": "M"}, {"family": "Ismail", "given": "Zaliha", "initials": "Z"}, {"family": "Ismayilova", "given": "Jamila", "initials": "J"}, {"family": "Jacobs", "given": "Asaf", "initials": "A"}, {"family": "Jakovljevi\u0107", "given": "Miro", "initials": "M"}, {"family": "Jak\u0161i\u0107", "given": "Nenad", "initials": "N"}, {"family": "Javed", "given": "Afzal", "initials": "A"}, {"family": "Kafali", "given": "Helin Yilmaz", "initials": "HY"}, {"family": "Karia", "given": "Sagar", "initials": "S"}, {"family": "Kazakova", "given": "Olga", "initials": "O"}, {"family": "Khalifa", "given": "Doaa", "initials": "D"}, {"family": "Khaustova", "given": "Olena", "initials": "O"}, {"family": "Koh", "given": "Steve", "initials": "S"}, {"family": "Kopishinskaia", "given": "Svetlana", "initials": "S"}, {"family": "Kosenko", "given": "Korneliia", "initials": "K"}, {"family": "Koupidis", "given": "Sotirios A", "initials": "SA"}, {"family": "Kovacs", "given": "Illes", "initials": "I"}, {"family": "Kulig", "given": "Barbara", "initials": "B"}, {"family": "Lalljee", "given": "Alisha", "initials": "A"}, {"family": "Liewig", "given": "Justine", "initials": "J"}, {"family": "Majid", "given": "Abdul", "initials": "A"}, {"family": "Malashonkova", "given": "Evgeniia", "initials": "E"}, {"family": "Malik", "given": "Khamelia", "initials": "K"}, {"family": "Malik", "given": "Najma Iqbal", "initials": "NI"}, {"family": "Mammadzada", "given": "Gulay", "initials": "G"}, {"family": "Mandalia", "given": "Bilvesh", "initials": "B"}, {"family": "Marazziti", "given": "Donatella", "initials": "D"}, {"family": "Mar\u010dinko", "given": "Darko", "initials": "D"}, {"family": "Martinez", "given": "Stephanie", "initials": "S"}, {"family": "Matiekus", "given": "Eimantas", "initials": "E"}, {"family": "Mejia", "given": "Gabriela", "initials": "G"}, {"family": "Memon", "given": "Roha Saeed", "initials": "RS"}, {"family": "Mart\u00ednez", "given": "Xarah Elenne Meza", "initials": "XEM"}, {"family": "Mickevi\u010di\u016bt\u0117", "given": "Dalia", "initials": "D"}, {"family": "Milev", "given": "Roumen", "initials": "R"}, {"family": "Mohammed", "given": "Muftau", "initials": "M"}, {"family": "Molina-L\u00f3pez", "given": "Alejandro", "initials": "A"}, {"family": "Morozov", "given": "Petr", "initials": "P"}, {"family": "Muhammad", "given": "Nuru Suleiman", "initials": "NS"}, {"family": "Musta\u010d", "given": "Filip", "initials": "F"}, {"family": "Naor", "given": "Mika S", "initials": "MS"}, {"family": "Nassieb", "given": "Amira", "initials": "A"}, {"family": "Navickas", "given": "Alvydas", "initials": "A"}, {"family": "Okasha", "given": "Tarek", "initials": "T"}, {"family": "Pandova", "given": "Milena", "initials": "M"}, {"family": "Panfil", "given": "Anca-Livia", "initials": "AL"}, {"family": "Panteleeva", "given": "Liliya", "initials": "L"}, {"family": "Papava", "given": "Ion", "initials": "I"}, {"family": "Patsali", "given": "Mikaella E", "initials": "ME"}, {"family": "Pavlichenko", "given": "Alexey", "initials": "A"}, {"family": "Pejuskovic", "given": "Bojana", "initials": "B"}, {"family": "Da Costa", "given": "Mariana Pinto", "initials": "MP"}, {"family": "Popkov", "given": "Mikhail", "initials": "M"}, {"family": "Popovic", "given": "Dina", "initials": "D"}, {"family": "Raduan", "given": "Nor Jannah Nasution", "initials": "NJN"}, {"family": "Ram\u00edrez", "given": "Francisca Vargas", "initials": "FV"}, {"family": "Rancans", "given": "Elmars", "initials": "E"}, {"family": "Razali", "given": "Salmi", "initials": "S"}, {"family": "Rebok", "given": "Federico", "initials": "F"}, {"family": "Rewekant", "given": "Anna", "initials": "A"}, {"family": "Flores", "given": "Elena Ninoska Reyes", "initials": "ENR"}, {"family": "Rivera-Encinas", "given": "Mar\u00eda Teresa", "initials": "MT"}, {"family": "Saiz", "given": "Pilar", "initials": "P"}, {"family": "de Carmona", "given": "Manuel S\u00e1nchez", "initials": "MS"}, {"family": "Mart\u00ednez", "given": "David Saucedo", "initials": "DS"}, {"family": "Saw", "given": "Jo Anne", "initials": "JA"}, {"family": "Saygili", "given": "G\u00f6rkem", "initials": "G"}, {"family": "Schneidereit", "given": "Patricia", "initials": "P"}, {"family": "Shah", "given": "Bhumika", "initials": "B"}, {"family": "Shirasaka", "given": "Tomohiro", "initials": "T"}, {"family": "Silagadze", "given": "Ketevan", "initials": "K"}, {"family": "Sitanggang", "given": "Satti", "initials": "S"}, {"family": "Skugarevsky", "given": "Oleg", "initials": "O"}, {"family": "Spikina", "given": "Anna", "initials": "A"}, {"family": "Mahalingappa", "given": "Sridevi Sira", "initials": "SS"}, {"family": "Stoyanova", "given": "Maria", "initials": "M"}, {"family": "Szczegielniak", "given": "Anna", "initials": "A"}, {"family": "Tamasan", "given": "Simona Claudia", "initials": "SC"}, {"family": "Tavormina", "given": "Giuseppe", "initials": "G"}, {"family": "Tavormina", "given": "Maurilio Giuseppe Maria", "initials": "MGM"}, {"family": "Theodorakis", "given": "Pavlos N", "initials": "PN"}, {"family": "Tohen", "given": "Mauricio", "initials": "M"}, {"family": "Tsapakis", "given": "Eva Maria", "initials": "EM"}, {"family": "Tukhvatullina", "given": "Dina", "initials": "D"}, {"family": "Ullah", "given": "Irfan", "initials": "I"}, {"family": "Vaidya", "given": "Ratnaraj", "initials": "R"}, {"family": "Vega-Dienstmaier", "given": "Johann M", "initials": "JM"}, {"family": "Vrublevska", "given": "Jelena", "initials": "J"}, {"family": "Vukovic", "given": "Olivera", "initials": "O"}, {"family": "Vysotska", "given": "Olga", "initials": "O"}, {"family": "Widiasih", "given": "Natalia", "initials": "N"}, {"family": "Yashikhina", "given": "Anna", "initials": "A"}, {"family": "Prezerakos", "given": "Panagiotis E", "initials": "PE"}, {"family": "Smirnova", "given": "Daria", "initials": "D"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "volume": "315", "pages": "114702", "issn-l": null}, "abstract": "During the COVID-19 pandemic various degrees of lockdown were applied by countries around the world. It is considered that such measures have an adverse effect on mental health but the relationship of measure intensity with the mental health effect has not been thoroughly studied. Here we report data from the larger COMET-G study pertaining to this question.\n\nDuring the COVID-19 pandemic, data were gathered with an online questionnaire from 55,589 participants from 40 countries (64.85% females aged 35.80 \u00b1 13.61; 34.05% males aged 34.90\u00b113.29 and 1.10% other aged 31.64\u00b113.15). Anxiety was measured with the STAI, depression with the CES-D and suicidality with the RASS. Distress and probable depression were identified with the use of a previously developed cut-off and algorithm respectively.\n\nIt included the calculation of Relative Risk (RR), Factorial ANOVA and Multiple backwards stepwise linear regression analysis RESULTS: Approximately two-thirds were currently living under significant restrictions due to lockdown. For both males and females the risk to develop clinical depression correlated significantly with each and every level of increasing lockdown degree (RR 1.72 and 1.90 respectively). The combined lockdown and psychiatric history increased RR to 6.88 The overall relationship of lockdown with severity of depression, though significant was small.\n\nThe current study is the first which reports an almost linear relationship between lockdown degree and effect in mental health. Our findings, support previous suggestions concerning the need for a proactive targeted intervention to protect mental health more specifically in vulnerable groups.", "doi": "10.1016/j.psychres.2022.114702", "pmid": "35839639", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(22)00298-0"}, {"db": "pmc", "key": "PMC9247180"}], "notes": [], "created": "2022-08-12T08:55:50.569Z", "modified": "2022-08-12T08:55:50.575Z"}, {"entity": "publication", "iuid": "9cc5dabbdf0a4825a47370d9e992c94b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9cc5dabbdf0a4825a47370d9e992c94b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9cc5dabbdf0a4825a47370d9e992c94b"}}, "title": "Suicide numbers during the first 9-15 months of the COVID-19 pandemic compared with pre-existing trends: An interrupted time series analysis in 33 countries.", "authors": [{"family": "Pirkis", "given": "Jane", "initials": "J"}, {"family": "Gunnell", "given": "David", "initials": "D"}, {"family": "Shin", "given": "Sangsoo", "initials": "S"}, {"family": "Del Pozo-Banos", "given": "Marcos", "initials": "M"}, {"family": "Arya", "given": "Vikas", "initials": "V"}, {"family": "Aguilar", "given": "Pablo Analuisa", "initials": "PA"}, {"family": "Appleby", "given": "Louis", "initials": "L"}, {"family": "Arafat", "given": "S M Yasir", "initials": "SMY"}, {"family": "Arensman", "given": "Ella", "initials": "E"}, {"family": "Ayuso-Mateos", "given": "Jose Luis", "initials": "JL"}, {"family": "Balhara", "given": "Yatan Pal Singh", "initials": "YPS"}, {"family": "Bantjes", "given": "Jason", "initials": "J"}, {"family": "Baran", "given": "Anna", "initials": "A"}, {"family": "Behera", "given": "Chittaranjan", "initials": "C"}, {"family": "Bertolote", "given": "Jose", "initials": "J"}, {"family": "Borges", "given": "Guilherme", "initials": "G"}, {"family": "Bray", "given": "Michael", "initials": "M"}, {"family": "Bre\u010di\u0107", "given": "Petrana", "initials": "P"}, {"family": "Caine", "given": "Eric", "initials": "E"}, {"family": "Calati", "given": "Raffaella", "initials": "R"}, {"family": "Carli", "given": "Vladimir", "initials": "V"}, {"family": "Castelpietra", "given": "Giulio", "initials": "G"}, {"family": "Chan", "given": "Lai Fong", "initials": "LF"}, {"family": "Chang", "given": "Shu-Sen", "initials": "SS"}, {"family": "Colchester", "given": "David", "initials": "D"}, {"family": "Coss-Guzm\u00e1n", "given": "Maria", "initials": "M"}, {"family": "Crompton", "given": "David", "initials": "D"}, {"family": "\u0106urkovi\u0107", "given": "Marko", "initials": "M"}, {"family": "Dandona", "given": "Rakhi", "initials": "R"}, {"family": "De Jaegere", "given": "Eva", "initials": "E"}, {"family": "De Leo", "given": "Diego", "initials": "D"}, {"family": "Deisenhammer", "given": "Eberhard A", "initials": "EA"}, {"family": "Dwyer", "given": "Jeremy", "initials": "J"}, {"family": "Erlangsen", "given": "Annette", "initials": "A"}, {"family": "Faust", "given": "Jeremy S", "initials": "JS"}, {"family": "Fornaro", "given": "Michele", "initials": "M"}, {"family": "Fortune", "given": "Sarah", "initials": "S"}, {"family": "Garrett", "given": "Andrew", "initials": "A"}, {"family": "Gentile", "given": "Guendalina", "initials": "G"}, {"family": "Gerstner", "given": "Rebekka", "initials": "R"}, {"family": "Gilissen", "given": "Renske", "initials": "R"}, {"family": "Gould", "given": "Madelyn", "initials": "M"}, {"family": "Gupta", "given": "Sudhir Kumar", "initials": "SK"}, {"family": "Hawton", "given": "Keith", "initials": "K"}, {"family": "Holz", "given": "Franziska", "initials": "F"}, {"family": "Kamenshchikov", "given": "Iurii", "initials": "I"}, {"family": "Kapur", "given": "Navneet", "initials": "N"}, {"family": "Kasal", "given": "Alexandr", "initials": "A"}, {"family": "Khan", "given": "Murad", "initials": "M"}, {"family": "Kirtley", "given": "Olivia J", "initials": "OJ"}, {"family": "Knipe", "given": "Duleeka", "initials": "D"}, {"family": "K\u00f5lves", "given": "Kairi", "initials": "K"}, {"family": "K\u00f6lzer", "given": "Sarah C", "initials": "SC"}, {"family": "Krivda", "given": "Hryhorii", "initials": "H"}, {"family": "Leske", "given": "Stuart", "initials": "S"}, {"family": "Madeddu", "given": "Fabio", "initials": "F"}, {"family": "Marshall", "given": "Andrew", "initials": "A"}, {"family": "Memon", "given": "Anjum", "initials": "A"}, {"family": "Mittendorfer-Rutz", "given": "Ellenor", "initials": "E"}, {"family": "Nestadt", "given": "Paul", "initials": "P"}, {"family": "Neznanov", "given": "Nikolay", "initials": "N"}, {"family": "Niederkrotenthaler", "given": "Thomas", "initials": "T"}, {"family": "Nielsen", "given": "Emma", "initials": "E"}, {"family": "Nordentoft", "given": "Merete", "initials": "M"}, {"family": "Oberlerchner", "given": "Herwig", "initials": "H"}, {"family": "O'Connor", "given": "Rory C", "initials": "RC"}, {"family": "Papsdorf", "given": "Rainer", "initials": "R"}, {"family": "Partonen", "given": "Timo", "initials": "T"}, {"family": "Phillips", "given": "Michael R", "initials": "MR"}, {"family": "Platt", "given": "Steve", "initials": "S"}, {"family": "Portzky", "given": "Gwendolyn", "initials": "G"}, {"family": "Psota", "given": "Georg", "initials": "G"}, {"family": "Qin", "given": "Ping", "initials": "P"}, {"family": "Radeloff", "given": "Daniel", "initials": "D"}, {"family": "Reif", "given": "Andreas", "initials": "A"}, {"family": "Reif-Leonhard", "given": "Christine", "initials": "C"}, {"family": "Rezaeian", "given": "Mohsen", "initials": "M"}, {"family": "Rom\u00e1n-V\u00e1zquez", "given": "Nayda", "initials": "N"}, {"family": "Roskar", "given": "Saska", "initials": "S"}, {"family": "Rozanov", "given": "Vsevolod", "initials": "V"}, {"family": "Sara", "given": "Grant", "initials": "G"}, {"family": "Scavacini", "given": "Karen", "initials": "K"}, {"family": "Schneider", "given": "Barbara", "initials": "B"}, {"family": "Semenova", "given": "Natalia", "initials": "N"}, {"family": "Sinyor", "given": "Mark", "initials": "M"}, {"family": "Tambuzzi", "given": "Stefano", "initials": "S"}, {"family": "Townsend", "given": "Ellen", "initials": "E"}, {"family": "Ueda", "given": "Michiko", "initials": "M"}, {"family": "Wasserman", "given": "Danuta", "initials": "D"}, {"family": "Webb", "given": "Roger T", "initials": "RT"}, {"family": "Winkler", "given": "Petr", "initials": "P"}, {"family": "Yip", "given": "Paul S F", "initials": "PSF"}, {"family": "Zalsman", "given": "Gil", "initials": "G"}, {"family": "Zoja", "given": "Riccardo", "initials": "R"}, {"family": "John", "given": "Ann", "initials": "A"}, {"family": "Spittal", "given": "Matthew J", "initials": "MJ"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": "51", "pages": "101573", "issn-l": null}, "abstract": "Predicted increases in suicide were not generally observed in the early months of the COVID-19 pandemic. However, the picture may be changing and patterns might vary across demographic groups. We aimed to provide a timely, granular picture of the pandemic's impact on suicides globally.\n\nWe identified suicide data from official public-sector sources for countries/areas-within-countries, searching websites and academic literature and contacting data custodians and authors as necessary. We sent our first data request on 22nd June 2021 and stopped collecting data on 31st October 2021. We used interrupted time series (ITS) analyses to model the association between the pandemic's emergence and total suicides and suicides by sex-, age- and sex-by-age in each country/area-within-country. We compared the observed and expected numbers of suicides in the pandemic's first nine and first 10-15 months and used meta-regression to explore sources of variation.\n\nWe sourced data from 33 countries (24 high-income, six upper-middle-income, three lower-middle-income; 25 with whole-country data, 12 with data for area(s)-within-the-country, four with both). There was no evidence of greater-than-expected numbers of suicides in the majority of countries/areas-within-countries in any analysis; more commonly, there was evidence of lower-than-expected numbers. Certain sex, age and sex-by-age groups stood out as potentially concerning, but these were not consistent across countries/areas-within-countries. In the meta-regression, different patterns were not explained by countries' COVID-19 mortality rate, stringency of public health response, economic support level, or presence of a national suicide prevention strategy. Nor were they explained by countries' income level, although the meta-regression only included data from high-income and upper-middle-income countries, and there were suggestions from the ITS analyses that lower-middle-income countries fared less well.\n\nAlthough there are some countries/areas-within-countries where overall suicide numbers and numbers for certain sex- and age-based groups are greater-than-expected, these countries/areas-within-countries are in the minority. Any upward movement in suicide numbers in any place or group is concerning, and we need to remain alert to and respond to changes as the pandemic and its mental health and economic consequences continue.\n\nNone.", "doi": "10.1016/j.eclinm.2022.101573", "pmid": "35935344", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(22)00303-0"}, {"db": "pmc", "key": "PMC9344880"}], "notes": [], "created": "2022-08-11T11:54:15.512Z", "modified": "2022-08-11T11:54:31.471Z"}, {"entity": "publication", "iuid": "e7bc0812ea3a459ca640b1d9f5195864", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e7bc0812ea3a459ca640b1d9f5195864.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e7bc0812ea3a459ca640b1d9f5195864"}}, "title": "Observed protection against SARS-CoV-2 reinfection following a primary infection: A Danish cohort study among unvaccinated using two years of nationwide PCR-test data.", "authors": [{"family": "Michlmayr", "given": "Daniela", "initials": "D"}, {"family": "Hansen", "given": "Christian Holm", "initials": "CH"}, {"family": "Gubbels", "given": "Sophie Madeleine", "initials": "SM"}, {"family": "Valentiner-Branth", "given": "Palle", "initials": "P"}, {"family": "Bager", "given": "Peter", "initials": "P"}, {"family": "Obel", "given": "Niels", "initials": "N"}, {"family": "Drewes", "given": "Birgitte", "initials": "B"}, {"family": "M\u00f8ller", "given": "Camilla Holten", "initials": "CH"}, {"family": "M\u00f8ller", "given": "Frederik Trier", "initials": "FT"}, {"family": "Legarth", "given": "Rebecca", "initials": "R"}, {"family": "M\u00f8lbak", "given": "K\u00e5re", "initials": "K"}, {"family": "Ethelberg", "given": "Steen", "initials": "S"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "20", "pages": "100452", "issn-l": null}, "abstract": "The level of protection after a SARS-CoV-2 infection against reinfection and COVID-19 disease remains important with much of the world still unvaccinated.\n\nAnalysing nationwide, individually referable, Danish register data including RT-PCR-test results, we conducted a cohort study using Cox regression to compare SARS-CoV-2 infection rates before and after a primary infection among still unvaccinated individuals, adjusting for sex, age, comorbidity and residency region. Estimates of protection against infection were calculated as 1 minus the hazard ratio. Estimates of protection against symptomatic infections and infections leading to hospitalisation were also calculated. The prevalence of infections classified as symptomatic or asymptomatic was compared for primary infections and reinfections. The study also assessed protection against each of the main viral variants after a primary infection with an earlier variant by restricting follow-up time to distinct, mutually exclusive periods during which each variant dominated.\n\nUntil 1 July 2021 the estimated protection against reinfection was 83.4% (95%CI: 82.2-84.6%); but lower for the 65+ year-olds (72.2%; 95%CI: 53.2-81.0%). Moderately higher estimates were found for protection against symptomatic disease, 88.3% overall (95%CI: 85.9-90.3%). First-time cases who reported no symptoms were more likely to experience a reinfection (odds ratio: 1.48; 95%CI: 1.35-1.62). By autumn 2021, when infections were almost exclusively caused by the Delta variant, the estimated protection following a recent first infection was 91.3% (95%CI: 89.7-92.7%) compared to 71.4% (95%CI: 66.9-75.3%) after a first infection over a year earlier. With Omicron, a first infection with an earlier variant in the past 3-6 months gave an estimated 51.0% (95%CI: 50.1-52.0%) protection, whereas a first infection longer than 12 months earlier provided only 19.0% (95%CI: 17.2-20.5%) protection. Protection by an earlier variant-infection against hospitalisation due to a new infection was estimated at: 86.6% (95%CI: 46.3-96.7%) for Alpha, 97.2% (95%CI: 89.0-99.3%) for Delta, and 69.8% (95%CI: 51.5-81.2%) for the Omicron variant.\n\nSARS-CoV-2 infection offered a high level of sustained protection against reinfection, comparable with that offered by vaccines, but decreased with the introduction of new main virus variants; dramatically so when Omicron appeared. Protection was lower among the elderly but appeared more pronounced following symptomatic compared to asymptomatic infections. The level of estimated protection against serious disease was somewhat higher than that against infection and possibly longer lasting. Decreases in protection against reinfection, seemed primarily to be driven by viral evolution.\n\nNone.", "doi": "10.1016/j.lanepe.2022.100452", "pmid": "35791335", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(22)00146-6"}, {"db": "pmc", "key": "PMC9245510"}], "notes": [], "created": "2022-08-17T13:07:20.171Z", "modified": "2022-08-17T13:07:20.177Z"}, {"entity": "publication", "iuid": "8794c597e5324ef1ab64bcd361a60c3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8794c597e5324ef1ab64bcd361a60c3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8794c597e5324ef1ab64bcd361a60c3d"}}, "title": "Initiation of antihypertensive drugs to patients with confirmed COVID-19-A population-based cohort study in Sweden.", "authors": [{"family": "Mousa", "given": "Salar Issa", "initials": "SI"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Hajiebrahimi", "given": "Mohammadhossein", "initials": "M", "orcid": "0000-0001-8118-4988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8338602bdf4d40ffb25713e73b1fc719.json"}}, {"family": "Bertilsson", "given": "Rebecka", "initials": "R"}, {"family": "N\u00e5tman", "given": "Jonatan", "initials": "J"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0003-0531-2516", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4911f8524d634e928a77f67c40e1610d.json"}}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Basic Clin Pharmacol Toxicol", "issn": "1742-7843", "volume": "131", "issue": "3", "pages": "196-204", "issn-l": null}, "abstract": "Hypertension is an important risk factor for severe outcomes in patients with COVID-19, and antihypertensive drugs may have a protective effect. However, the pandemic may have negatively impacted health care services for chronic diseases. The aim of this study was to assess initiations of antihypertensive medicines in patients infected by COVID-19.\n\nA cohort study including all Swedish residents 20-80 years old with a COVID-19 positive test compared with an unexposed group without COVID-19 matched for age, sex, and index date (date of confirmed COVID-19). Data were collected within SCIFI-PEARL, a study including linked data on COVID tests, hospital diagnoses, dispensed prescriptions, and socioeconomic data from Swedish national registers. Initiations of different antihypertensive drugs were studied from March 2020 until October 2020. Associations between COVID-19 and initiation of antihypertensives were assessed by a multivariable Cox proportional hazards model.\n\nA total of 224 582 patients (exposed and unexposed) were included. After adjusting for cardiovascular comorbidities and education level, ACEi was the most commonly initiated antihypertensive agent to patients with COVID-19. Hazard ratio and 95% confidence interval for initiation of drug therapy was 1.83 [1.53-2.19] for ACEi, followed by beta-blockers 1.74 [1.55-1.95], calcium channel blockers 1.61 [1.41-1.83], angiotensin receptor blockers 1.61 [1.40-1.86], and diuretics 1.53 [1.32-1.77].\n\nAll antihypertensive medicines were initiated more frequently in COVID-19 patients. This can either be associated with hypertension caused by the COVID-19 infection, more frequent diagnosis of hypertension among people with COVID-19 since they consult health care, or residual confounding factors not adjusted for in the study.", "doi": "10.1111/bcpt.13766", "pmid": "35726121", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9349802"}], "notes": [], "created": "2022-08-17T13:05:13.777Z", "modified": "2022-08-17T13:05:13.888Z"}, {"entity": "publication", "iuid": "3ac144a28cbb44b5bf6a5d2d018dd811", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ac144a28cbb44b5bf6a5d2d018dd811.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ac144a28cbb44b5bf6a5d2d018dd811"}}, "title": "Increased antidepressant use during the COVID-19 pandemic: Findings from the Friuli Venezia Giulia region, Italy, 2015-2020.", "authors": [{"family": "Pazzagli", "given": "Laura", "initials": "L"}, {"family": "Reutfors", "given": "Johan", "initials": "J"}, {"family": "Lucian", "given": "Ejlli", "initials": "E"}, {"family": "Zerial", "given": "Giovanna", "initials": "G"}, {"family": "Perulli", "given": "Alfredo", "initials": "A"}, {"family": "Castelpietra", "given": "Giulio", "initials": "G"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "volume": "315", "pages": "114704", "issn-l": null}, "abstract": "Few studies investigated the impact of the pandemic on antidepressant (AD) use.\n\nThe Social and Health Information System of Friuli Venezia Giulia region, Italy, provided data on AD use. Sex, age, AD class and month used the amount of AD prescriptions, measured by defined daily doses (DDD) per 1000 inhabitants per day, to compare AD use in 2020 with the period 2015-2019. A linear trend model predicted AD use for 2020, based on years 2015-2019.\n\nAD use was on average 20% higher in each month of 2020 when compared with the same month for the period 2015-2019, with an increase of more than 30% in the first four and in the last two months of 2020. The observed AD use in 2020 was higher than predicted, particularly in men, and in the 30-59 years age group.\n\nDescriptive study of AD use without analysis of data at the individual level. No information on psychiatric diagnoses of AD users.\n\nAD use was higher in the first year of the COVID-19 pandemic. Further research is warranted to understand if this may be related to a rise in mental disorders in the general population during the COVID-19 pandemic.", "doi": "10.1016/j.psychres.2022.114704", "pmid": "35830755", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(22)00300-6"}, {"db": "pmc", "key": "PMC9245333"}], "notes": [], "created": "2022-08-17T10:34:16.218Z", "modified": "2022-08-17T10:35:06.031Z"}, {"entity": "publication", "iuid": "7810c03718d54d36b6ca5230a6a64161", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7810c03718d54d36b6ca5230a6a64161.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7810c03718d54d36b6ca5230a6a64161"}}, "title": "Impaired immunity and high attack rates caused by SARS-CoV-2 variants among vaccinated long-term care facility residents.", "authors": [{"family": "Obach", "given": "Doroth\u00e9e", "initials": "D"}, {"family": "Solastie", "given": "Anna", "initials": "A", "orcid": "0000-0002-3848-2768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/95c7cbcd3ad843b4b74b9650e1d78f4a.json"}}, {"family": "Liedes", "given": "Oona", "initials": "O"}, {"family": "Vara", "given": "Saimi", "initials": "S"}, {"family": "Krzy\u017cewska-Dudek", "given": "Eva", "initials": "E", "orcid": "0000-0002-5581-1690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b24b973fe1674251af971a0112680320.json"}}, {"family": "Brinkmann", "given": "Luise", "initials": "L"}, {"family": "Haveri", "given": "Anu", "initials": "A", "orcid": "0000-0003-4620-7536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad75e87cc8d34f5cb3849a646d0e5e99.json"}}, {"family": "Hammer", "given": "Charlotte C", "initials": "CC"}, {"family": "Dub", "given": "Timoth\u00e9e", "initials": "T"}, {"family": "Meri", "given": "Seppo", "initials": "S", "orcid": "0000-0001-9142-501X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51708db39bbc477e9e94d09f99bab271.json"}}, {"family": "Freitag", "given": "Tobias L", "initials": "TL"}, {"family": "Lyytik\u00e4inen", "given": "Outi", "initials": "O"}, {"family": "Melin", "given": "Merit", "initials": "M"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Immun Inflamm Dis", "issn": "2050-4527", "volume": "10", "issue": "9", "pages": "e679", "issn-l": null}, "abstract": "Long-term care facilities (LTCF) residents are at high risk for severe coronavirus disease 2019 (COVID-19), and therefore, COVID-19 vaccinations were prioritized for residents and personnel in Finland at the beginning of 2021.\n\nWe investigated COVID-19 outbreaks in two LTCFs, where residents were once or twice vaccinated. After the outbreaks we measured immunoglobulin G (IgG) antibodies to severe acute respiratory syndrome coronavirus 2 spike glycoprotein, neutralizing antibody (NAb) titers, and cell-mediated immunity markers from residents and healthcare workers (HCWs).\n\nIn LTFC-1, the outbreak was caused by an Alpha variant (B.1.1.7) and the attack rate (AR) among once vaccinated residents was 23%. In LTCF-2 the outbreak was caused by a Beta variant (B.1.351). Its AR was 47% although all residents had received their second dose 1 month before the outbreak. We observed that vaccination had induced lower IgG concentrations, NAb titers and cell-mediated immune responses in residents compared to HCWs. Only 1/8 residents had NAb to the Beta variant after two vaccine doses.\n\nThe vaccinated elderly remain susceptible to breakthrough infections caused by Alpha and Beta variants. The weaker vaccine response in the elderly needs to be addressed in vaccination protocols, while new variants capable of evading vaccine-induced immunity continue to emerge.", "doi": "10.1002/iid3.679", "pmid": "36039644", "labels": {"Category: Vaccines": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9382858"}], "notes": [], "created": "2022-10-07T12:48:28.482Z", "modified": "2022-10-07T12:48:28.632Z"}, {"entity": "publication", "iuid": "8dbd78fd144c4e50a77459317b2f5262", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8dbd78fd144c4e50a77459317b2f5262.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8dbd78fd144c4e50a77459317b2f5262"}}, "title": "Immunomodulation by intravenous omega-3 fatty acid treatment in older subjects hospitalized for COVID-19: A single-blind randomized controlled trial.", "authors": [{"family": "Arnardottir", "given": "Hildur", "initials": "H", "orcid": "0000-0002-5163-3946", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/942fb973fd3e4a1e8f85c10e6fff4423.json"}}, {"family": "Pawelzik", "given": "Sven-Christian", "initials": "SC", "orcid": "0000-0001-8704-6607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5249b23453a347a883217f7c90cfeb00.json"}}, {"family": "Sarajlic", "given": "Philip", "initials": "P", "orcid": "0000-0002-8690-7994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a623ec0669142d889964c3a5697d109.json"}}, {"family": "Quaranta", "given": "Alessandro", "initials": "A", "orcid": "0000-0002-3167-3772", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7821ced4ee8842d69ae9081bde5278d7.json"}}, {"family": "Kolmert", "given": "Johan", "initials": "J"}, {"family": "Religa", "given": "Dorota", "initials": "D", "orcid": "0000-0003-4583-4570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e2c968ecffa4c638126d6d8d4a0dbd9.json"}}, {"family": "Wheelock", "given": "Craig E", "initials": "CE", "orcid": "0000-0002-8113-0653", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7fe4d1cc7804c6d9d1506dc8db516ea.json"}}, {"family": "B\u00e4ck", "given": "Magnus", "initials": "M", "orcid": "0000-0003-0853-5141", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a3a2ec52b7044719f83c4863b5cdb7b.json"}}], "type": "letter", "published": "2022-09-00", "journal": {"title": "Clin Transl Med", "issn": "2001-1326", "volume": "12", "issue": "9", "pages": "e895", "issn-l": null}, "abstract": null, "doi": "10.1002/ctm2.895", "pmid": "36121173", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9484265"}], "notes": [], "created": "2022-10-13T13:36:26.009Z", "modified": "2023-06-19T15:19:23.363Z"}, {"entity": "publication", "iuid": "884a9a950c48485eafe0e7de1980add6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/884a9a950c48485eafe0e7de1980add6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/884a9a950c48485eafe0e7de1980add6"}}, "title": "Geographical distribution of cystic fibrosis carriers as population genetic determinant of COVID-19 spread and fatality in 37 countries.", "authors": [{"family": "Gabbi", "given": "Chiara", "initials": "C"}, {"family": "Renieri", "given": "Alessandra", "initials": "A"}, {"family": "Strandvik", "given": "Birgitta", "initials": "B"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "J Infect", "issn": "1532-2742", "volume": "85", "issue": "3", "pages": "318-321", "issn-l": "0163-4453"}, "abstract": "COVID-19 has shown a relevant heterogeneity in spread and fatality among countries together with a significant variability in its clinical presentation, indicating that host genetic factors may influence COVID-19 pathogenicity. Indeed, subjects carrying single pathogenic variants of the Cystic Fibrosis (CF) Transmembrane Conductance Regulator (CFTR) gene - i.e. CF carriers - are more susceptible to respiratory tract infections and are more likely to undergo severe COVID-19 with higher risk of 14-day mortality. Given that CF carrier prevalence varies among ethnicities and nations, an ecological study in 37 countries was conducted, in order to determine to what extent the diverse CF carrier geographical distribution may have affected COVID-19 spread and fatality during the first pandemic wave. The CF prevalence in countries, as indicator of the geographical distribution of CF carriers, significantly correlated in a direct manner with both COVID-19 prevalence and its Case Fatality Rate (CFR). In a regression study weighted for the number of tests performed, COVID-19 prevalence positively correlated with CF prevalence, while CFR correlated with population percentage older than 65-year, cancer and CF prevalence. Multivariate regression model also confirmed COVID-19 CFR to be associated with CF prevalence, after adjusting for elderly, cancer prevalence, and weighting for the number of tests performed. This study suggests a putative contribution of population genetics of CFTR in understanding the spatial distribution of COVID-19 spread and fatality.", "doi": "10.1016/j.jinf.2022.06.006", "pmid": "35700866", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0163-4453(22)00359-0"}, {"db": "pmc", "key": "PMC9188282"}], "notes": [], "created": "2022-06-20T18:15:47.594Z", "modified": "2022-08-17T13:01:42.707Z"}, {"entity": "publication", "iuid": "3806cd89b54a4248bc55b0da0ad24174", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3806cd89b54a4248bc55b0da0ad24174.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3806cd89b54a4248bc55b0da0ad24174"}}, "title": "Design and Analysis of Studies Based on Hierarchical Composite Endpoints: Insights from the DARE-19 Trial.", "authors": [{"family": "Gasparyan", "given": "Samvel B", "initials": "SB", "orcid": "0000-0002-4797-2208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fe0aea6b8d940a4aa97beac64753452.json"}}, {"family": "Buenconsejo", "given": "Joan", "initials": "J", "orcid": "0000-0003-4514-2208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90cef2fa64d0486681f64332929d92cf.json"}}, {"family": "Kowalewski", "given": "Elaine K", "initials": "EK", "orcid": "0000-0002-7915-877X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0c063ae9205470c9803add8044303bc.json"}}, {"family": "Oscarsson", "given": "Jan", "initials": "J", "orcid": "0000-0002-4573-517X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40a4f5060bd147c08b93f49e441ed37c.json"}}, {"family": "Bengtsson", "given": "Olof F", "initials": "OF", "orcid": "0000-0003-1315-8176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ae11bf6102548649d358e95a3f44766.json"}}, {"family": "Esterline", "given": "Russell", "initials": "R"}, {"family": "Koch", "given": "Gary G", "initials": "GG"}, {"family": "Berwanger", "given": "Otavio", "initials": "O"}, {"family": "Kosiborod", "given": "Mikhail N", "initials": "MN"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Ther Innov Regul Sci", "issn": "2168-4804", "volume": "56", "issue": "5", "pages": "785-794", "issn-l": null}, "abstract": "DARE-19 (NCT04350593) was a randomized trial studying the effects of dapagliflozin, an SGLT2 inhibitor, in hospitalized patients with COVID-19 pneumonia and cardiometabolic risk factors. The conduct of DARE-19 offered the opportunity to define an innovative and clinically meaningful endpoint in a new disease that would best reflect the known profile of dapagliflozin, accompanied by the statistical challenges of analysis and interpretation of such a novel endpoint.\n\nHierarchical composite endpoints (HCEs) are based on clinical outcomes which, unlike traditional composite endpoints incorporate ranking of components according to clinical importance. Design of an HCE requires the clinical considerations specific to the therapeutic area under study and the mechanism of action of the investigational treatment. Statistical aspects for the clinical endpoints include the proper definition of the estimand as suggested by ICH E9(R1) for the precise specification of the treatment effect measured by an HCE.\n\nWe describe the estimand of the DARE-19 trial, where an HCE was constructed to capture the treatment effect of dapagliflozin in hospitalized patients with COVID-19, and was analyzed using a win odds. Practical aspects of designing new studies based on an HCE are described. These include sample size, power, and minimal detectable effect calculations for an HCE based on the win odds analysis, as well as handling of missing data and the clinical interpretability of the win odds in relation to the estimand.\n\nHCEs are flexible endpoints that can be adapted for use in different therapeutic areas, with win odds as the analysis method. DARE-19 is an example of a COVID-19 trial with an HCE as one of the primary endpoints for estimating a clinically interpretable treatment effect in the COVID-19 setting.", "doi": "10.1007/s43441-022-00420-1", "pmid": "35699910", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s43441-022-00420-1"}, {"db": "pmc", "key": "PMC9196151"}], "notes": [], "created": "2022-06-20T18:16:07.446Z", "modified": "2022-08-17T13:02:09.052Z"}, {"entity": "publication", "iuid": "8101495174ac4c04b2cfde72073ef8fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8101495174ac4c04b2cfde72073ef8fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8101495174ac4c04b2cfde72073ef8fa"}}, "title": "COVID-19 clinical outcomes and DMT of MS patients and population-based controls.", "authors": [{"family": "Longinetti", "given": "Elisa", "initials": "E", "orcid": "0000-0002-4789-7172", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c376d8f47e6b4624861918e0f33abb6f.json"}}, {"family": "Bower", "given": "Hannah", "initials": "H"}, {"family": "McKay", "given": "Kyla A", "initials": "KA", "orcid": "0000-0002-9081-1522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8049ba5c52eb42c7bb866f5eee749173.json"}}, {"family": "Englund", "given": "Simon", "initials": "S", "orcid": "0000-0002-1042-4400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f87dfdb3db6f49d385f5266fa53e6262.json"}}, {"family": "Burman", "given": "Joachim", "initials": "J"}, {"family": "Fink", "given": "Katharina", "initials": "K"}, {"family": "Fogdell-Hahn", "given": "Anna", "initials": "A"}, {"family": "Gunnarsson", "given": "Martin", "initials": "M"}, {"family": "Hillert", "given": "Jan", "initials": "J"}, {"family": "Langer-Gould", "given": "Annette", "initials": "A", "orcid": "0000-0001-6891-7147", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fae9d189a7444ecc91c521031c9c1f9b.json"}}, {"family": "Lycke", "given": "Jan", "initials": "J"}, {"family": "Nilsson", "given": "Petra", "initials": "P"}, {"family": "Salzer", "given": "Jonatan", "initials": "J"}, {"family": "Svenningsson", "given": "Anders", "initials": "A"}, {"family": "Mellerg\u00e5rd", "given": "Johan", "initials": "J"}, {"family": "Olsson", "given": "Tomas", "initials": "T"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Frisell", "given": "Thomas", "initials": "T", "orcid": "0000-0002-5735-9626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e9d6be8c47b4d6eb80bd3d57a63172e.json"}}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Ann Clin Transl Neurol", "issn": "2328-9503", "volume": "9", "issue": "9", "pages": "1449-1458", "issn-l": "2328-9503"}, "abstract": "To estimate risks for all-cause mortality and for severe COVID-19 in multiple sclerosis patients and across relapsing-remitting multiple sclerosis patients exposed to disease-modifying therapies.\n\nWe conducted a Swedish nationwide population-based multi-register linkage cohort study and followed all multiple sclerosis patients (n = 17,692 in March 2020), individually age-, sex-, and region-matched to five population-based controls (n = 86,176 in March 2020) during March 2020-June 2021. We compared annual all-cause mortality within and across cohorts, and assessed incidence rates and relative risks for hospitalization, intensive care admission, and death due to COVID-19 in relation to disease-modifying therapy use, using Cox regression.\n\nAbsolute all-cause mortality among multiple sclerosis patients was higher from March to December 2020 than in previous years, but relative risks versus the population-based controls were similar to preceding years. Incidence rates of hospitalization, intensive care admission, and death due to COVID-19 remained in line with those for all-cause hospitalization, intensive care admission, and mortality. Among relapsing-remitting patients on rituximab, trends for differences in risk of hospitalization due to COVID-19 remained in the demographics-, socioeconomic status-, comorbidity-, and multiple sclerosis severity-adjusted model.\n\nRisks of severe COVID-19-related outcomes were increased among multiple sclerosis patients as a whole compared to population controls, but risk increases were also seen for non-COVID-19 hospitalization, intensive care admission, and mortality, and did not significantly differ during the pandemic compared to pre-pandemic years. The risk conveyed by disease-modifying therapies was smaller than previously assumed, likely as a consequence of the possibility to better control for confounders.", "doi": "10.1002/acn3.51646", "pmid": "35993445", "labels": {"Category: Biochemistry": null, "Research Area: Vaccine": null, "Funder: VR": null, "Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:54:21.518Z", "modified": "2022-09-12T18:54:33.463Z"}, {"entity": "publication", "iuid": "54071614f63543689180c5efe559a5f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54071614f63543689180c5efe559a5f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54071614f63543689180c5efe559a5f1"}}, "title": "Age-specific associations between underlying health conditions and hospitalisation, death and in-hospital death among confirmed COVID-19 cases: a multi-country study based on surveillance data, June to December 2020.", "authors": [{"family": "Funk", "given": "Tjede", "initials": "T"}, {"family": "Innocenti", "given": "Francesco", "initials": "F"}, {"family": "Gomes Dias", "given": "Joana", "initials": "J"}, {"family": "Nerlander", "given": "Lina", "initials": "L"}, {"family": "Melillo", "given": "Tanya", "initials": "T"}, {"family": "Gauci", "given": "Charmaine", "initials": "C"}, {"family": "Melillo", "given": "Jackie M", "initials": "JM"}, {"family": "Lenz", "given": "Patrik", "initials": "P"}, {"family": "Sebestova", "given": "Helena", "initials": "H"}, {"family": "Slezak", "given": "Pavel", "initials": "P"}, {"family": "Vlckova", "given": "Iva", "initials": "I"}, {"family": "Berild", "given": "Jacob Dag", "initials": "JD"}, {"family": "Mauroy", "given": "Camilla", "initials": "C"}, {"family": "Sepp\u00e4l\u00e4", "given": "Elina", "initials": "E"}, {"family": "T\u00f8nnessen", "given": "Ragnhild", "initials": "R"}, {"family": "Vergison", "given": "Anne", "initials": "A"}, {"family": "Mossong", "given": "Jo\u00ebl", "initials": "J"}, {"family": "Masi", "given": "Silvana", "initials": "S"}, {"family": "Huiart", "given": "Laetitia", "initials": "L"}, {"family": "Cullen", "given": "Gillian", "initials": "G"}, {"family": "Murphy", "given": "Niamh", "initials": "N"}, {"family": "O'Connor", "given": "Lois", "initials": "L"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}, {"family": "Mook", "given": "Piers", "initials": "P"}, {"family": "Pebody", "given": "Richard G", "initials": "RG"}, {"family": "Bundle", "given": "Nick", "initials": "N"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "27", "issue": "35", "issn-l": null}, "abstract": "BackgroundUnderlying conditions are risk factors for severe COVID-19 outcomes but evidence is limited about how risks differ with age.AimWe sought to estimate age-specific associations between underlying conditions and hospitalisation, death and in-hospital death among COVID-19 cases.MethodsWe analysed case-based COVID-19 data submitted to The European Surveillance System between 2 June and 13 December 2020 by nine European countries. Eleven underlying conditions among cases with only one condition and the number of underlying conditions among multimorbid cases were used as exposures. Adjusted odds ratios (aOR) were estimated using 39 different age-adjusted and age-interaction multivariable logistic regression models, with marginal means from the latter used to estimate probabilities of severe outcome for each condition-age group combination.ResultsCancer, cardiac disorder, diabetes, immunodeficiency, kidney, liver and lung disease, neurological disorders and obesity were associated with elevated risk (aOR: 1.5-5.6) of hospitalisation and death, after controlling for age, sex, reporting period and country. As age increased, age-specific aOR were lower and predicted probabilities higher. However, for some conditions, predicted probabilities were at least as high in younger individuals with the condition as in older cases without it. In multimorbid patients, the aOR for severe disease increased with number of conditions for all outcomes and in all age groups.ConclusionWhile supporting age-based vaccine roll-out, our findings could inform a more nuanced, age- and condition-specific approach to vaccine prioritisation. This is relevant as countries consider vaccination of younger people, boosters and dosing intervals in response to vaccine escape variants.", "doi": "10.2807/1560-7917.ES.2022.27.35.2100883", "pmid": "36052721", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9438397"}], "notes": [], "created": "2022-10-13T13:20:13.681Z", "modified": "2022-10-13T13:20:29.741Z"}, {"entity": "publication", "iuid": "cb78eca0dc3f4bbdba776bbbb624f273", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cb78eca0dc3f4bbdba776bbbb624f273.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cb78eca0dc3f4bbdba776bbbb624f273"}}, "title": "Acute Stress among Nurses in Sweden during the COVID-19 Pandemic.", "authors": [{"family": "Palmborg", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "L\u00f6tvall", "given": "Rebecka", "initials": "R"}, {"family": "Carde\u00f1a", "given": "Etzel", "initials": "E"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Eur J Trauma Dissociation", "issn": "2468-7499", "issn-l": null, "volume": "6", "issue": "3", "pages": "100283"}, "abstract": "Sweden was hit hard in the beginning of the COVID-19 pandemic with deaths per capita among the highest in Europe. The pandemic was a stressful time especially for healthcare workers caring for COVID-19 patients. Various studies have evaluated whether nurses caring for these patients had higher levels of acute stress, but typically with measures that either used older DSM-IV criteria for Acute Stress Disorder (ASD) or general measures of acute stress. We recruited an online sample (N = 101) of nurses in Sweden from COVID-19 specialized units (ICU), Emergency (ER), and other units (Other), and asked them to answer questionnaires retrospectively to the peak of infections in Sweden. We aimed to evaluate: 1) the psychometric properties of the translation of the Stanford Acute Stress Reaction Questionnaire-II (SASRQ-II, which follows DSM-5 criteria for ASD) into Swedish, 2) whether nurses in COVID-19 units had experienced more acute stress than nurses in other units, and 3) the extent of potential acute stress disorder. The SASRQ-II evidenced good construct, convergent and divergent validity, and good reliability. It showed that ICU nurses reported significantly more acute stress than the other two groups, a difference that could not be accounted for by demographic or other variables. A retrospective diagnosis of ASD using the SASRQ-II suggested that 60% of nurses might have fulfilled ASD criteria, but no differences across groups were found.", "doi": "10.1016/j.ejtd.2022.100283", "pmid": "37521718", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC9153182"}, {"db": "pii", "key": "S2468-7499(22)00025-4"}], "notes": [], "created": "2023-10-04T12:10:42.579Z", "modified": "2023-10-04T13:29:52.549Z"}, {"entity": "publication", "iuid": "1de3abb226014908b7f0b2e74a72bc10", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1de3abb226014908b7f0b2e74a72bc10.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1de3abb226014908b7f0b2e74a72bc10"}}, "title": "Computational investigation of the increased virulence and pathogenesis of SARS-CoV-2 lineage B.1.1.7.", "authors": [{"family": "Murugan", "given": "N Arul", "initials": "NA", "orcid": "0000-0003-0185-5724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/293acfd743f94993bd6aca57b01cd604.json"}}, {"family": "Javali", "given": "Prashanth S", "initials": "PS"}, {"family": "Pandianb", "given": "Chitra Jeyaraj", "initials": "CJ"}, {"family": "Ali", "given": "Muhammad Akhtar", "initials": "MA"}, {"family": "Srivastava", "given": "Vaibhav", "initials": "V"}, {"family": "Jeyaraman", "given": "Jeyakanthan", "initials": "J"}], "type": "journal article", "published": "2022-08-31", "journal": {"title": "Phys Chem Chem Phys", "issn": "1463-9084", "volume": "24", "issue": "34", "pages": "20371-20380", "issn-l": null}, "abstract": "New variants of SARS-CoV-2 are being reported worldwide. The World Health Organization has reported Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2) and Omicron (B.1.1.529) as the variants of concern. There are speculations that the variants might evade the host immune responses induced by currently available vaccines and develop resistance to drugs under consideration. The first step of viral infection in COVID-19 occurs through the interaction of the spike protein's receptor-binding domain (RBD) with the peptidase domain of the human ACE-2 (hACE-2) receptor. This study aims to get a molecular-level understanding of the mechanism behind the increased infection rate in the alpha variant. We have computationally studied the spike protein interaction in both the wild-type and B.1.1.7 variant with the hACE-2 receptor using molecular dynamics and MM-GBSA based binding free energy calculations. The binding free energy difference shows that the mutant variant of the spike protein has increased binding affinity for the hACE-2 receptor (i.e. \u0394G(N501Y,A570D) is in the range -7.2 to -7.6 kcal mol-1) and the results were validated using Density functional theory. We demonstrate that with the use of state-of-the-art computational approaches, we can, in advance, predict the virulent nature of variants of SARS-CoV-2 and alert the world healthcare system.", "doi": "10.1039/d2cp00469k", "pmid": "35983778", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:46:02.036Z", "modified": "2022-09-12T18:46:11.422Z"}, {"entity": "publication", "iuid": "95b56a5bc5fd4409a812fb103435b7f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95b56a5bc5fd4409a812fb103435b7f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95b56a5bc5fd4409a812fb103435b7f8"}}, "title": "Target trial emulation: applying principles of randomised trials to observational studies.", "authors": [{"family": "Matthews", "given": "Anthony A", "initials": "AA"}, {"family": "Danaei", "given": "Goodarz", "initials": "G"}, {"family": "Islam", "given": "Nazrul", "initials": "N"}, {"family": "Kurth", "given": "Tobias", "initials": "T"}], "type": "journal article", "published": "2022-08-30", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "378", "pages": "e071108", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj-2022-071108", "pmid": "36041749", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-10-07T12:52:13.418Z", "modified": "2022-10-07T12:52:13.430Z"}, {"entity": "publication", "iuid": "7aea51599cb44f5bbd01b5b25ee4a2c3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7aea51599cb44f5bbd01b5b25ee4a2c3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7aea51599cb44f5bbd01b5b25ee4a2c3"}}, "title": "Standing alone: experiences of vaccine-hesitant Danish healthcare professionals during COVID-19.", "authors": [{"family": "Mars\u00e5", "given": "Kristoffer", "initials": "K"}, {"family": "Kristensen", "given": "Tina B\u00f8gelund", "initials": "TB", "orcid": "0000-0002-1337-2714", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04953b581b8d473f8775c9129a9cc439.json"}}, {"family": "Konradsen", "given": "Hanne", "initials": "H", "orcid": "0000-0002-7477-125X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b462d15cdeec4dcb8371e07cf2e97853.json"}}], "type": "journal article", "published": "2022-08-29", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "14034948221113645", "issn-l": "1403-4948"}, "abstract": "The aim of the study was to explore the experiences of Danish healthcare professionals who were hesitant about the COVID-19 vaccine.\n\nInterviews were conducted over the telephone in January and February 2021.\n\nHealthcare professionals experienced the need to avoid impossible conversations about vaccine hesitancy with their colleagues. They felt a lack of knowledge of long-term experience with the vaccine and a need to balance trust in themselves and the authorities.\n\nHealthcare professionals who were hesitant towards the COVID-19 vaccine felt they had to keep their concerns to themselves and felt isolated and pressured by their managers. This study is especially important for managers, who must ensure a trusting working environment in which employees can discuss their concerns without feeling pressured.", "doi": "10.1177/14034948221113645", "pmid": "36032021", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9425156"}], "notes": [], "created": "2022-10-07T12:42:10.132Z", "modified": "2022-10-07T12:42:10.202Z"}, {"entity": "publication", "iuid": "a10443d35eb74f0f9cf02dc552aa961f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a10443d35eb74f0f9cf02dc552aa961f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a10443d35eb74f0f9cf02dc552aa961f"}}, "title": "Early coronavirus disease 2019 restrictive measures and changes in maternal characteristics, use of assisted reproductive technology, and stillbirth.", "authors": [{"family": "Lisonkova", "given": "Sarka", "initials": "S", "orcid": "0000-0002-1220-310X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fa6497ba976450d811710f9d17d7cdf.json"}}, {"family": "Bone", "given": "Jeffrey N", "initials": "JN", "orcid": "0000-0001-7704-1677", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89c39d4178c944cda324b0f521aa290f.json"}}, {"family": "Muraca", "given": "Giulia M", "initials": "GM"}, {"family": "Razaz", "given": "Neda", "initials": "N", "orcid": "0000-0002-1273-0110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f21859df7854ccba80df15feb16afe1.json"}}, {"family": "Boutin", "given": "Amelie", "initials": "A", "orcid": "0000-0003-1907-2920", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cc105166eb549ed85144b0066c7cb8c.json"}}, {"family": "Brandt", "given": "Justin S", "initials": "JS", "orcid": "0000-0002-3194-1087", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90c6660c689c499c996f99485ece89f5.json"}}, {"family": "Bedaiwy", "given": "Mohamed A", "initials": "MA"}, {"family": "Ananth", "given": "Cande V", "initials": "CV", "orcid": "0000-0002-0410-2595", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/efc995667f254ca7b334d8acb15bf40c.json"}}, {"family": "Joseph", "given": "K S", "initials": "KS", "orcid": "0000-0003-2317-5607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56f6530185df4ed0884f76187da81fc1.json"}}], "type": "journal article", "published": "2022-08-29", "journal": {"title": "Paediatr Perinat Epidemiol", "issn": "1365-3016", "issn-l": null}, "abstract": "The initial COVID-19 pandemic response-related effects on conceptions following the use of assisted reproductive technologies (ART), and on changes in the maternal characteristics of women who conceived during the early vs. pre-pandemic period, have been understudied.\n\nTo examine the effects of ART clinic closures in the United States (US) in March 2020 on the frequency of ART-conceived live births, multiple births and stillbirths; and to describe changes in the characteristics of women who conceived in the early pandemic period.\n\nPopulation-based cohort study including all births in the US from January 2015 to December 2020 (22,907,688 live births; 134,537 stillbirths). Interrupted time series (ITS) methodology was used to estimate rate ratios (RR) of expected versus observed rates in December 2020 (i.e., among births conceived mainly in March 2020). Demographic and clinical characteristics were compared between mothers who conceived in March 2020 versus March 2015-2019.\n\nOverall, 1.1% of live births and 1.7% of stillbirths were conceived by ART. ART-conceived live births decreased by 57.0% in December 2020 (observed vs. expected RR 0.43, 95% confidence interval [CI] 0.40, 0.45), and these declines occurred in all subgroups of women. Multiple births also declined in December 2020. Stillbirth rates increased in December 2020 in ART-conceived births (RR 2.55, 95% CI 1.63, 3.92) but remained unchanged in the non-ART group. Maternal characteristics of women who conceived in the early pandemic versus pre-pandemic period differed and included an increased prevalence of pre-pregnancy obesity class 3 and chronic hypertension.\n\nThe early pandemic closure of ART clinics resulted in a substantial decline in ART-conceived live births and multiple births in December 2020 and an increase in the proportion of stillbirths among ART-conceived births. Women who conceived in the early pandemic period also had an increased prevalence of obesity and chronic hypertension.", "doi": "10.1111/ppe.12925", "pmid": "36038519", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-10-07T12:46:40.148Z", "modified": "2022-10-07T12:46:40.410Z"}, {"entity": "publication", "iuid": "3b7806103bd5433bb21a91e8f197bef2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b7806103bd5433bb21a91e8f197bef2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b7806103bd5433bb21a91e8f197bef2"}}, "title": "Vascular Aging and COVID-19.", "authors": [{"family": "Badaras", "given": "Ignas", "initials": "I", "orcid": "0000-0002-9423-6641", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/454778bb8e734071b6de754a38336a45.json"}}, {"family": "Lau\u010dyt\u0117-Cibulskien\u0117", "given": "Agn\u0117", "initials": "A"}], "type": "journal article", "published": "2022-08-28", "journal": {"title": "Angiology", "issn": "1940-1574", "pages": "33197221121007", "issn-l": null}, "abstract": "Vascular age is determined by functional and structural changes in the arterial wall. When measured by its proxy, pulse wave velocity, it has been shown to predict cardiovascular and total mortality. Disconcordance between chronological and vascular age might represent better or worse vascular health. Cell senescence is caused by oxidative stress and sustained cell replication. Senescent cells acquire senescence-associated secretory phenotype. Oxidative stress, endothelial dysfunction, dysregulation of coagulation and leucocyte infiltration are observed in the aging endothelium. All of these mechanisms lead to increased vascular calcification and stiffness. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can involve the vascular endothelium. It enters cells using angiotensin-converting enzyme 2 (ACE-2) receptors, which are abundant in endothelial cells. The damage this virus does to the endothelium can be direct or indirect. Indirect damage is caused by hyperinflammation. Direct damage results from effects on ACE-2 receptors. The reduction of ACE-2 levels seen during coronavirus disease 2019 (COVID-19) infection might cause vasoconstriction and oxidative stress. COVID-19 and vascular aging share some pathways. Due to the novelty of the virus, there is an urgent need for studies that investigate its long-term effects on vascular health.", "doi": "10.1177/00033197221121007", "pmid": "36031949", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9421419"}], "notes": [], "created": "2022-10-07T12:41:44.367Z", "modified": "2022-10-07T12:41:44.456Z"}, {"entity": "publication", "iuid": "40f0eb51bec5406f9a482adfb5912ef0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/40f0eb51bec5406f9a482adfb5912ef0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/40f0eb51bec5406f9a482adfb5912ef0"}}, "title": "Impact of the COVID-19 pandemic on total, sex- and age-specific all-cause mortality in 20 countries worldwide during 2020: results from the C-MOR project.", "authors": [{"family": "Demetriou", "given": "Christiana A", "initials": "CA"}, {"family": "Achilleos", "given": "Souzana", "initials": "S"}, {"family": "Quattrocchi", "given": "Annalisa", "initials": "A"}, {"family": "Gabel", "given": "John", "initials": "J"}, {"family": "Critselis", "given": "Elena", "initials": "E"}, {"family": "Constantinou", "given": "Constantina", "initials": "C"}, {"family": "Nicolaou", "given": "Nicoletta", "initials": "N"}, {"family": "Ambrosio", "given": "Giuseppe", "initials": "G"}, {"family": "Bennett", "given": "Catherine M", "initials": "CM"}, {"family": "Le Meur", "given": "Nolwenn", "initials": "N", "orcid": "0000-0001-8451-4014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7ccd56127144ac4b7044dfaf98ca8e6.json"}}, {"family": "Critchley", "given": "Julia A", "initials": "JA"}, {"family": "Mortensen", "given": "Laust Hvas", "initials": "LH"}, {"family": "Rodriguez-Llanes", "given": "Jose Manuel", "initials": "JM", "orcid": "0000-0003-3736-736X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/63855d33d8924205b7a3f4cf7f826ee2.json"}}, {"family": "Chong", "given": "Mario", "initials": "M"}, {"family": "Denissov", "given": "Gleb", "initials": "G"}, {"family": "Klepac", "given": "Petra", "initials": "P"}, {"family": "Goldsmith", "given": "Lucy P", "initials": "LP"}, {"family": "Costa", "given": "Antonio Jos\u00e9 Leal", "initials": "AJL"}, {"family": "Hagen", "given": "Terje P", "initials": "TP"}, {"family": "Chan Sun", "given": "Marie", "initials": "M"}, {"family": "Huang", "given": "Qian", "initials": "Q"}, {"family": "Pidmurniak", "given": "Nataliia", "initials": "N"}, {"family": "Zucker", "given": "Inbar", "initials": "I"}, {"family": "Cuthbertson", "given": "Joseph", "initials": "J"}, {"family": "Burstr\u00f6m", "given": "Bo", "initials": "B"}, {"family": "Barron", "given": "Manuel", "initials": "M"}, {"family": "Er\u017een", "given": "Ivan", "initials": "I"}, {"family": "Stracci", "given": "Fabrizio", "initials": "F"}, {"family": "Calmon", "given": "Wilson", "initials": "W"}, {"family": "Martial", "given": "Cyndy", "initials": "C"}, {"family": "Verstiuk", "given": "Olesia", "initials": "O"}, {"family": "Kaufman", "given": "Zalman", "initials": "Z"}, {"family": "Tao", "given": "Wenjing", "initials": "W"}, {"family": "Kereselidze", "given": "Maia", "initials": "M"}, {"family": "Chikhladze", "given": "Nino", "initials": "N"}, {"family": "Polemitis", "given": "Antonis", "initials": "A"}, {"family": "Charalambous", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2022-08-27", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "issn-l": "0300-5771"}, "abstract": "To understand the impact of the COVID-19 pandemic on mortality, this study investigates overall, sex- and age-specific excess all-cause mortality in 20 countries, during 2020.\n\nTotal, sex- and age-specific weekly all-cause mortality for 2015-2020 was collected from national vital statistics databases. Excess mortality for 2020 was calculated by comparing weekly 2020 observed mortality against expected mortality, estimated from historical data (2015-2019) accounting for seasonality, long- and short-term trends. Crude and age-standardized rates were analysed for total and sex-specific mortality.\n\nAustria, Brazil, Cyprus, England and Wales, France, Georgia, Israel, Italy, Northern Ireland, Peru, Scotland, Slovenia, Sweden, and the USA displayed substantial excess age-standardized mortality of varying duration during 2020, while Australia, Denmark, Estonia, Mauritius, Norway, and Ukraine did not. In sex-specific analyses, excess mortality was higher in males than females, except for Slovenia (higher in females) and Cyprus (similar in both sexes). Lastly, for most countries substantial excess mortality was only detectable (Austria, Cyprus, Israel, and Slovenia) or was higher (Brazil, England and Wales, France, Georgia, Italy, Northern Ireland, Sweden, Peru and the USA) in the oldest age group investigated. Peru demonstrated substantial excess mortality even in the <45 age group.\n\nThis study highlights that excess all-cause mortality during 2020 is context dependent, with specific countries, sex- and age-groups being most affected. As the pandemic continues, tracking excess mortality is important to accurately estimate the true toll of COVID-19, while at the same time investigating the effects of changing contexts, different variants, testing, quarantine, and vaccination strategies.", "doi": "10.1093/ije/dyac170", "pmid": "36029524", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6678067"}, {"db": "pmc", "key": "PMC9452146"}], "notes": [], "created": "2022-10-07T12:39:47.036Z", "modified": "2022-10-07T12:39:47.118Z"}, {"entity": "publication", "iuid": "f128d077fdaf4127bdbe1a3b9f04c3af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f128d077fdaf4127bdbe1a3b9f04c3af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f128d077fdaf4127bdbe1a3b9f04c3af"}}, "title": "Presentations of children to emergency departments across Europe and the COVID-19 pandemic: A multinational observational study.", "authors": [{"family": "Nijman", "given": "Ruud G", "initials": "RG", "orcid": "0000-0001-9671-8161", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26477162984840c0bf7a96f496f7c297.json"}}, {"family": "Honeyford", "given": "Kate", "initials": "K", "orcid": "0000-0002-5533-7693", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/106c36a2e1a8490686043452d0913882.json"}}, {"family": "Farrugia", "given": "Ruth", "initials": "R", "orcid": "0000-0002-1553-2486", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a73c5db5b3014380ac3872f27d73b578.json"}}, {"family": "Rose", "given": "Katy", "initials": "K", "orcid": "0000-0002-2020-4161", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be8a1e5aaf9c45b4a154d0f8a03d9974.json"}}, {"family": "Bognar", "given": "Zsolt", "initials": "Z", "orcid": "0000-0002-3744-9333", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e785ea593bba4834bdc5e3f23ddb815d.json"}}, {"family": "Buonsenso", "given": "Danilo", "initials": "D", "orcid": "0000-0001-8567-2639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e070622b9414c78b60ffe8128c2b199.json"}}, {"family": "Da Dalt", "given": "Liviana", "initials": "L", "orcid": "0000-0003-2977-3907", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e19bb4da28564137afdfb37221e0ed5c.json"}}, {"family": "De", "given": "Tisham", "initials": "T", "orcid": "0000-0001-7278-0534", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/326ea5db5b964d999e5476cd57954362.json"}}, {"family": "Maconochie", "given": "Ian K", "initials": "IK", "orcid": "0000-0001-6319-8550", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4777830b1d77433d8415df99b156c9d5.json"}}, {"family": "Parri", "given": "Niccolo", "initials": "N", "orcid": "0000-0002-8098-2504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b286f0ff29b402da7baa7f2fd324a1f.json"}}, {"family": "Roland", "given": "Damian", "initials": "D", "orcid": "0000-0001-9334-5144", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd56730130484fc29a5e6c8e30d39146.json"}}, {"family": "Alfven", "given": "Tobias", "initials": "T", "orcid": "0000-0002-2328-3512", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3851560b984401780a380ab1262cd8b.json"}}, {"family": "Aupiais", "given": "Camille", "initials": "C", "orcid": "0000-0001-7482-0405", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d81b1aa343a43129b778f6ff77da0f7.json"}}, {"family": "Barrett", "given": "Michael", "initials": "M", "orcid": "0000-0003-1775-8347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/55f3b1f81f834837af0d4e3d5c6a10bb.json"}}, {"family": "Basmaci", "given": "Romain", "initials": "R"}, {"family": "Borensztajn", "given": "Dorine", "initials": "D", "orcid": "0000-0002-2437-0757", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/916d54dab1494022b1e099689d96afe2.json"}}, {"family": "Castanhinha", "given": "Susana", "initials": "S", "orcid": "0000-0003-0762-7730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c3142588768e44a181ffeb24f1fc3968.json"}}, {"family": "Vasilico", "given": "Corrine", "initials": "C", "orcid": "0000-0001-8911-1097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/622935bca334454295b551f4b1a4ddd6.json"}}, {"family": "Durnin", "given": "Sheena", "initials": "S", "orcid": "0000-0002-5109-3417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ddf91f56cbd41e799cb59f67331a5dd.json"}}, {"family": "Fitzpatrick", "given": "Paddy", "initials": "P"}, {"family": "Fodor", "given": "Laszlo", "initials": "L", "orcid": "0000-0002-4984-4058", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6751db52f71146f49325f9ae87377ca3.json"}}, {"family": "Gomez", "given": "Borja", "initials": "B", "orcid": "0000-0001-6542-4494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21a0b7480f814dc9b295d90064ff20df.json"}}, {"family": "Greber-Platzer", "given": "Susanne", "initials": "S", "orcid": "0000-0002-3706-8370", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a396b96cb774df8b0d7ee369bdf31a0.json"}}, {"family": "Guedj", "given": "Romain", "initials": "R"}, {"family": "Hartshorn", "given": "Stuart", "initials": "S", "orcid": "0000-0003-0419-1564", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd07611e3974424596f1c06a15b0c64f.json"}}, {"family": "Hey", "given": "Florian", "initials": "F", "orcid": "0000-0001-6183-5798", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40a5401c6a28450fa7739f459f5944cf.json"}}, {"family": "Jankauskaite", "given": "Lina", "initials": "L", "orcid": "0000-0002-6997-4917", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a66e27835a87452181c6d16d37d8a60d.json"}}, {"family": "Kohlfuerst", "given": "Daniela", "initials": "D", "orcid": "0000-0002-1188-9525", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c89a5b53f956492285bbd9eb41486dc4.json"}}, {"family": "Kolnik", "given": "Mojca", "initials": "M", "orcid": "0000-0003-4194-7295", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01ae84eef06542a69573bb235e792b2d.json"}}, {"family": "Lyttle", "given": "Mark D", "initials": "MD", "orcid": "0000-0002-8634-7210", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c196102c81b4abf843cdaed12fe1cd5.json"}}, {"family": "Ma\u00e7\u00e3o", "given": "Patr\u00edcia", "initials": "P"}, {"family": "Mascarenhas", "given": "Maria In\u00eas", "initials": "MI"}, {"family": "Messahel", "given": "Shrouk", "initials": "S", "orcid": "0000-0003-0645-3070", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2654e67acf45429f9c86751a25e1918c.json"}}, {"family": "\u00d6zkan", "given": "Esra Aky\u00fcz", "initials": "EA"}, {"family": "Pu\u010duka", "given": "Zanda", "initials": "Z", "orcid": "0000-0002-6070-3563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1eb4a8297132442aaccf4bf4f7541407.json"}}, {"family": "Reis", "given": "Sofia", "initials": "S"}, {"family": "Rybak", "given": "Alexis", "initials": "A", "orcid": "0000-0002-2898-3710", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eca3664e52894d278a9b8e58d8bd7572.json"}}, {"family": "Ryd Rinder", "given": "Malin", "initials": "M", "orcid": "0000-0002-2947-4117", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b87e79413e84d8bb0a71a16fa3975fc.json"}}, {"family": "Teksam", "given": "Ozlem", "initials": "O"}, {"family": "Turan", "given": "Caner", "initials": "C", "orcid": "0000-0001-9469-5162", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e60e2d771749443283698d7c9c68bbc4.json"}}, {"family": "Thors", "given": "Valt\u00fdr Stef\u00e1nsson", "initials": "VS", "orcid": "0000-0002-0976-9604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe040ce0586f4aa69a84c26a4e58c0bd.json"}}, {"family": "Velasco", "given": "Roberto", "initials": "R", "orcid": "0000-0003-0073-2650", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/492e63741600403ea7a19017f167b203.json"}}, {"family": "Bressan", "given": "Silvia", "initials": "S"}, {"family": "Moll", "given": "Henriette A", "initials": "HA", "orcid": "0000-0001-9304-3322", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ef2448fc7e34cb3bce7b402eb9852cf.json"}}, {"family": "Oostenbrink", "given": "Rianne", "initials": "R", "orcid": "0000-0001-7919-8934", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3902bdbd1604b67b1b29c8ef8890323.json"}}, {"family": "Titomanlio", "given": "Luigi", "initials": "L", "orcid": "0000-0003-4909-803X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b9f5485226f4651afe8e9fa3594cf94.json"}}, {"family": "in association with the REPEM network (Research in European Pediatric Emergency Medicine) as part of the EPISODES study group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-08-26", "journal": {"title": "PLoS Med", "issn": "1549-1676", "volume": "19", "issue": "8", "pages": "e1003974", "issn-l": "1549-1277"}, "abstract": "During the initial phase of the Coronavirus Disease 2019 (COVID-19) pandemic, reduced numbers of acutely ill or injured children presented to emergency departments (EDs). Concerns were raised about the potential for delayed and more severe presentations and an increase in diagnoses such as diabetic ketoacidosis and mental health issues. This multinational observational study aimed to study the number of children presenting to EDs across Europe during the early COVID-19 pandemic and factors influencing this and to investigate changes in severity of illness and diagnoses.\n\nRoutine health data were extracted retrospectively from electronic patient records of children aged 18 years and under, presenting to 38 EDs in 16 European countries for the period January 2018 to May 2020, using predefined and standardized data domains. Observed and predicted numbers of ED attendances were calculated for the period February 2020 to May 2020. Poisson models and incidence rate ratios (IRRs), using predicted counts for each site as offset to adjust for case-mix differences, were used to compare age groups, diagnoses, and outcomes. Reductions in pediatric ED attendances, hospital admissions, and high triage urgencies were seen in all participating sites. ED attendances were relatively higher in countries with lower SARS-CoV-2 prevalence (IRR 2\u00b726, 95% CI 1\u00b790 to 2\u00b770, p < 0.001) and in children aged <12 months (12 to <24 months IRR 0\u00b786, 95% CI 0\u00b784 to 0\u00b789; 2 to <5 years IRR 0\u00b780, 95% CI 0\u00b778 to 0\u00b782; 5 to <12 years IRR 0\u00b768, 95% CI 0\u00b767 to 0\u00b770; 12 to 18 years IRR 0\u00b772, 95% CI 0\u00b770 to 0\u00b774; versus age <12 months as reference group, p < 0.001). The lowering of pediatric intensive care admissions was not as great as that of general admissions (IRR 1\u00b730, 95% CI 1\u00b716 to 1\u00b745, p < 0.001). Lower triage urgencies were reduced more than higher triage urgencies (urgent triage IRR 1\u00b710, 95% CI 1\u00b708 to 1\u00b712; emergent and very urgent triage IRR 1\u00b753, 95% CI 1\u00b749 to 1\u00b757; versus nonurgent triage category, p < 0.001). Reductions were highest and sustained throughout the study period for children with communicable infectious diseases. The main limitation was the retrospective nature of the study, using routine clinical data from a wide range of European hospitals and health systems.\n\nReductions in ED attendances were seen across Europe during the first COVID-19 lockdown period. More severely ill children continued to attend hospital more frequently compared to those with minor injuries and illnesses, although absolute numbers fell.\n\nISRCTN91495258 https://www.isrctn.com/ISRCTN91495258.", "doi": "10.1371/journal.pmed.1003974", "pmid": "36026507", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PMEDICINE-D-22-00899"}], "notes": [], "created": "2022-09-12T19:15:08.788Z", "modified": "2022-09-12T19:15:09.744Z"}, {"entity": "publication", "iuid": "019dcb91399048119825bcefe2415ec4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/019dcb91399048119825bcefe2415ec4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/019dcb91399048119825bcefe2415ec4"}}, "title": "Face mask use during the COVID-19 pandemic: how risk perception, experience with COVID-19, and attitude towards government interact with country-wide policy stringency.", "authors": [{"family": "Wismans", "given": "Annelot", "initials": "A"}, {"family": "van der Zwan", "given": "Peter", "initials": "P"}, {"family": "Wennberg", "given": "Karl", "initials": "K"}, {"family": "Franken", "given": "Ingmar", "initials": "I"}, {"family": "Mukerjee", "given": "Jinia", "initials": "J"}, {"family": "Baptista", "given": "Rui", "initials": "R"}, {"family": "Mar\u00edn", "given": "Jorge Barrientos", "initials": "JB"}, {"family": "Burke", "given": "Andrew", "initials": "A"}, {"family": "Dejardin", "given": "Marcus", "initials": "M"}, {"family": "Janssen", "given": "Frank", "initials": "F"}, {"family": "Letina", "given": "Srebrenka", "initials": "S"}, {"family": "Mill\u00e1n", "given": "Jos\u00e9 Mar\u00eda", "initials": "JM"}, {"family": "Santarelli", "given": "Enrico", "initials": "E"}, {"family": "Torr\u00e8s", "given": "Olivier", "initials": "O"}, {"family": "Thurik", "given": "Roy", "initials": "R"}], "type": "journal article", "published": "2022-08-26", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "1622", "issn-l": null}, "abstract": "During the 2020 COVID-19 pandemic, governments imposed numerous regulations to protect public health, particularly the (mandatory) use of face masks. However, the appropriateness and effectiveness of face mask regulations have been widely discussed, as is apparent from the divergent measures taken across and within countries over time, including mandating, recommending, and discouraging their use. In this study, we analyse how country-level policy stringency and individual-level predictors associate with face mask use during the early stages of the global COVID-19 pandemic.\n\nFirst, we study how (self and other-related) risk perception, (direct and indirect) experience with COVID-19, attitude towards government and policy stringency shape face mask use. Second, we study whether there is an interaction between policy stringency and the individual-level variables. We conduct multilevel analyses exploiting variation in face mask regulations across countries and using data from approximately 7000 students collected in the beginning of the pandemic (weeks 17 through 19, 2020).\n\nWe show that policy stringency is strongly positively associated with face mask use. We find a positive association between self-related risk perception and mask use, but no relationship of mask use with experience with COVID-19 and attitudes towards government. However, in the interaction analyses, we find that government trust and perceived clarity of communication moderate the link between stringency and mask use, with positive government perceptions relating to higher use in countries with regulations and to lower use in countries without regulations.\n\nWe highlight that those countries that aim for widespread use of face masks should set strict measures, stress self-related risks of COVID-19, and use clear communication.", "doi": "10.1186/s12889-022-13632-9", "pmid": "36028876", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-022-13632-9"}, {"db": "pmc", "key": "PMC9412789"}], "notes": [], "created": "2022-10-07T12:37:59.851Z", "modified": "2022-10-07T12:39:28.164Z"}, {"entity": "publication", "iuid": "178091f103d9489385c75bfcc5e42ed3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/178091f103d9489385c75bfcc5e42ed3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/178091f103d9489385c75bfcc5e42ed3"}}, "title": "Call for a unified approach to Monkeypox infection in pregnancy: Lessons from the COVID-19 pandemic.", "authors": [{"family": "Khalil", "given": "Asma", "initials": "A", "orcid": "0000-0003-2802-7670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e4558e368114cfb83c4594f523b38c0.json"}}, {"family": "Samara", "given": "Athina", "initials": "A", "orcid": "0000-0001-6931-1972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ef0cd4edca4b2a837d2b275da0be56.json"}}, {"family": "O'Brien", "given": "Pat", "initials": "P"}, {"family": "Ladhani", "given": "Shamez", "initials": "S"}], "type": "journal article", "published": "2022-08-26", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "5038", "issn-l": "2041-1723"}, "abstract": null, "doi": "10.1038/s41467-022-32638-w", "pmid": "36028491", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-022-32638-w"}, {"db": "pmc", "key": "PMC9412782"}], "notes": [], "created": "2022-10-07T12:37:23.211Z", "modified": "2022-10-07T12:37:35.174Z"}, {"entity": "publication", "iuid": "fb18b1397aad4f3c80a2af8860e8d27c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb18b1397aad4f3c80a2af8860e8d27c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb18b1397aad4f3c80a2af8860e8d27c"}}, "title": "Relatives' perspectives on encounters and communication in nursing homes during the Covid-19 pandemic: a qualitative interview study.", "authors": [{"family": "Eriksson", "given": "Elisabet", "initials": "E"}, {"family": "Hjelm", "given": "Katarina", "initials": "K"}], "type": "journal article", "published": "2022-08-25", "journal": {"title": "BMC Geriatr", "issn": "1471-2318", "volume": "22", "issue": "1", "pages": "706", "issn-l": null}, "abstract": "Relatives of nursing home (NH) residents have experienced national or local restrictions on visiting their elderly family member during the Covid-19 pandemic. Today, many NHs have a multicultural environment, as staff, residents and their relatives speak different languages. Thus far, studies of remote communication with staff with limited language skills during the Covid-19 pandemic are lacking.\n\nThe aim of the present study was to explore relatives' experiences of encounters and communication with staff and residents in NHs during the Covid-19 pandemic.\n\nAn explorative qualitative study using semi-structured telephone interviews with 17 relatives of NH residents (12 women and 5 men). Data were analyzed using qualitative content analysis to identify four main categories and nine sub-categories.\n\nCommunicating during visiting restrictions was challenging, and relatives experienced ups and downs when trying to stay in contact with NH residents and staff. Relatives received general information, but desired information about residents' everyday life without having to ask for it. Moreover, remote communication was difficult for residents with hearing impairment or dementia. Even relatives who understood different languages had to develop strategies to communicate with staff with limited language skills in Swedish and English. Relatives did not mention using translating applications to facilitate communication.\n\nDuring visiting restrictions, relatives lacked information about residents' everyday life and found communication with staff with limited language skills challenging. For this reason, and to enable communication with staff with limited language skills, there is a need to find practical and technical solutions for facilitating remote communication between relatives, residents and staff at NHs.", "doi": "10.1186/s12877-022-03364-1", "pmid": "36008775", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12877-022-03364-1"}, {"db": "pmc", "key": "PMC9409621"}], "notes": [], "created": "2022-09-12T19:08:33.469Z", "modified": "2022-09-12T19:08:33.475Z"}, {"entity": "publication", "iuid": "4b584f3911754e1a8a9dcdc1f132a940", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b584f3911754e1a8a9dcdc1f132a940.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b584f3911754e1a8a9dcdc1f132a940"}}, "title": "Global safety monitoring of COVID-19 vaccines: how pharmacovigilance rose to the challenge.", "authors": [{"family": "Rudolph", "given": "Annette", "initials": "A", "orcid": "0000-0003-2360-7174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5f0f8bf831a4539b0b7939d8a68ce73.json"}}, {"family": "Mitchell", "given": "Joseph", "initials": "J"}, {"family": "Barrett", "given": "Jim", "initials": "J"}, {"family": "Sk\u00f6ld", "given": "Helena", "initials": "H"}, {"family": "Taavola", "given": "Henric", "initials": "H"}, {"family": "Erlanson", "given": "Nils", "initials": "N"}, {"family": "Melgarejo-Gonz\u00e1lez", "given": "Carlos", "initials": "C"}, {"family": "Yue", "given": "Qun-Ying", "initials": "QY"}], "type": "journal article", "published": "2022-08-25", "journal": {"title": "Ther Adv Drug Saf", "issn": "2042-0986", "volume": "13", "pages": "20420986221118972", "issn-l": null}, "abstract": "Pharmacovigilance (PV) came suddenly into the spotlight when several new vaccines, developed as a response to the COVID-19 pandemic, received emergency authorisation and were rolled out on a large scale in late 2020. The vaccines underwent stringent clinical trials and evaluation from regulatory authorities, but with the use of novel technology and an anticipated rapid and vast deployment of the vaccines, the importance of a well-functioning international post marketing safety surveillance system was stressed. International PV stakeholders were faced with several challenges due to the extent of the global vaccination campaign. The unprecedented volume of reports of suspected adverse events following immunization has led to the development and use of new tools. Furthermore, the collaboration between various PV stakeholders was encouraged and strengthened. PV rose to the challenges posed by the currently ongoing global COVID-19 vaccination campaign and successful adaptations were made in a short period of time. However, the pandemic has not ended yet, the vaccination campaign is far from being completed, and further challenges are anticipated. Advances made during the pandemic will be important to strengthen PV in future and ensure to advance medicines' safety together.\n\nGlobal safety monitoring of the COVID-19 vaccines: challenges, preparations, and outlooks Pharmacovigilance (PV) is the umbrella term for all sciences and activities relating to the detection, assessment, understanding, and prevention of adverse effects relating to medicines or vaccines. PV came into the spotlight when several new vaccines were authorised and rolled out as a response to the COVID-19 pandemic.The anticipated extent of the global vaccine rollout stressed the importance of a well-functioning safety surveillance system and international collaborations between patients, health care workers, vaccine producers, regulatory authorities, and PV centres.The identification and communication of potential safety concerns showed that adaptations to PV processes made in a short period of time as well as international collaborations were successful. However, it is important to learn from experiences made so far and to make sure the positive advances are maintained in the future to advance medicines' safety together.", "doi": "10.1177/20420986221118972", "pmid": "36052399", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1177_20420986221118972"}, {"db": "pmc", "key": "PMC9424876"}], "notes": [], "created": "2022-10-13T13:19:14.175Z", "modified": "2022-10-13T13:19:40.906Z"}, {"entity": "publication", "iuid": "e069bf0f7d774e09ba6cec9630efdec7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e069bf0f7d774e09ba6cec9630efdec7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e069bf0f7d774e09ba6cec9630efdec7"}}, "title": "Testing for coronarvirus disease 2019 before cardiac surgery-safe outcome of infected patients.", "authors": [{"family": "Ivert", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Dal\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2022-08-24", "journal": {"title": "J Cardiothorac Surg", "issn": "1749-8090", "volume": "17", "issue": "1", "pages": "201", "issn-l": null}, "abstract": "The aim was to analyze routine preoperative testing for coronavirus disease 2019 (COVID-19) performed to avoid infected cardiac surgical patients transmitting virus during the pandemic.\n\nEvery patient scheduled to undergo cardiac surgery from March 2020 through December 2021 had preoperative polymerase-chain-reaction (PCR) test for COVID-19 by nasopharynx swabs. Any history of COVID-19 was recorded.\n\nIn 15 of 1870 patients (0.8%) with minimal or no airway symptoms unexpected positive PCR tests were detected, and surgery was deferred for two weeks. Totally 38 patients with negative tests had recovered without sequelae from previous COVID-19 a mean of 5 months before the operation. Sixteen patients (0.8%) developed airway symptoms within six weeks after the operation and had positive COVID-19 tests. Body Mass Index was higher and female gender, diabetes mellitus, chronic obstructive pulmonary disease and reduced left ventricular ejection fraction were more common in patients with than in those without COVID-19. Early postoperative outcomes did not differ significantly in patients with versus without COVID-19.\n\nAn unexpected preoperative positive COVID-19 test was detected in less than one percent of patients admitted for cardiac surgery during the pandemic. These operations were deferred to avoid transmission of virus in the hospital. Additionally, one percent of patients were diagnosed with positive COVID-19 tests within six weeks after the operation. There was no outbreak of COVID-19 among hospital staff or patients. All patients with COVID-19 before the operation were operated on safely and postoperative outcomes did not differ significantly compared with COVID-19 negative patients.", "doi": "10.1186/s13019-022-01960-1", "pmid": "36002897", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13019-022-01960-1"}], "notes": [], "created": "2022-08-26T04:43:06.006Z", "modified": "2022-08-26T04:43:07.222Z"}, {"entity": "publication", "iuid": "73c368a02dd448df81ac0b2d0060c6a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/73c368a02dd448df81ac0b2d0060c6a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/73c368a02dd448df81ac0b2d0060c6a1"}}, "title": "Experienced stigma and applied coping strategies during the COVID-19 pandemic in Germany: a mixed-methods study.", "authors": [{"family": "Peters", "given": "Lynn", "initials": "L", "orcid": "0000-0003-4882-6816", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ba436f73aa94aebad063825bea44f30.json"}}, {"family": "Burkert", "given": "Sanne", "initials": "S", "orcid": "0000-0002-9961-4170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/117c68feabcf4bc283cd0b542ea022f2.json"}}, {"family": "Brenner", "given": "Cecilia", "initials": "C"}, {"family": "Gr\u00fcner", "given": "Beate", "initials": "B", "orcid": "0000-0001-6669-3741", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c573876e2e9470badfe5d2b7498ac17.json"}}], "type": "journal article", "published": "2022-08-24", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "8", "pages": "e059472", "issn-l": "2044-6055"}, "abstract": "Health-related stigma is considered a social determinant of health equity and a hidden burden of disease. This study aimed to assess the level and dimensions of stigma and respective coping mechanisms in COVID-19 survivors.\n\nA mixed-methods study with sequential explanatory design was conducted at the University Hospital of Ulm, Germany. Stigma was assessed using the Social Impact Scale (SIS) including adult COVID-19 survivors with mild-to-severe disease. Subsequently, 14 participants were sampled with regard to gender, age and severity of disease for in-depth interviews to understand how stigma was experienced and coping strategies were applied. The questionnaire was analysed using descriptive statistics, t-test and analysis of variance. Content analysis was used for qualitative data.\n\nFrom 61 participants, 58% were men and mean age was 51 years. The quantitative analysis of the SIS indicated an intermediate level of experienced stigma. Participants experienced stigma mainly as 'social rejection' (M=14.22, SD=4.91), followed by 'social isolation' (M=10.17, SD=4.16) and 'internalised shame' (M=8.39, SD=3.32). There was no significant difference in experienced stigma regarding gender, education, occupational status or residual symptoms. However, participants between 30 and 39 years of age experienced higher levels of stigma than other age groups (p=0.034). The qualitative analysis revealed how stigma seemed to arise from misconceptions creating irrational fear of infection, leading to stereotyping, vilification, discrimination and social exclusion of COVID-19 survivors, leaving them feeling vulnerable. Stigma cut through all social levels, from the individual level at the bottom to the institutional and societal level at the top. Social networks protected from experiencing stigma.\n\nCOVID-19-related stigma is a relevant burden in the ongoing pandemic. Providing accurate information and exposing misinformation on disease prevention and treatment seems key to end COVID-19-related stigma.", "doi": "10.1136/bmjopen-2021-059472", "pmid": "36002206", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-059472"}], "notes": [], "created": "2022-08-26T04:43:29.779Z", "modified": "2022-08-26T04:43:29.903Z"}, {"entity": "publication", "iuid": "0c379fbf9ff74982b51c247c9d641a4b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c379fbf9ff74982b51c247c9d641a4b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c379fbf9ff74982b51c247c9d641a4b"}}, "title": "Characteristics and Outcomes of People With Gout Hospitalized Due to COVID-19: Data From the COVID-19 Global Rheumatology Alliance Physician-Reported Registry.", "authors": [{"family": "Jatuworapruk", "given": "Kanon", "initials": "K", "orcid": "0000-0002-9301-8941", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98c57555175a45dcae2058d1986dca81.json"}}, {"family": "Montgomery", "given": "Anna", "initials": "A", "orcid": "0000-0003-3333-7833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6be3cbe46a3b4190a31e190c195f7e77.json"}}, {"family": "Gianfrancesco", "given": "Milena", "initials": "M", "orcid": "0000-0002-8351-4626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dca9cada1314065ab094be6fc17524e.json"}}, {"family": "Conway", "given": "Richard", "initials": "R", "orcid": "0000-0003-2538-3362", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77fe264e6d0d4c87b734f3fa02e42c15.json"}}, {"family": "Durcan", "given": "Laura", "initials": "L", "orcid": "0000-0001-6585-2974", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/287c2710c1124f318c1c48f939654110.json"}}, {"family": "Graef", "given": "Elizabeth R", "initials": "ER", "orcid": "0000-0001-5973-3477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a80ffebe8ad44d34b27689cd1a699229.json"}}, {"family": "Jayatilleke", "given": "Aruni", "initials": "A", "orcid": "0000-0003-0875-4280", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a87e2f22a51b4e5c9300063078169b8a.json"}}, {"family": "Keen", "given": "Helen", "initials": "H", "orcid": "0000-0002-8469-2424", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fc442133e9f4dda9baa0b83d732ce63.json"}}, {"family": "Kilian", "given": "Adam", "initials": "A", "orcid": "0000-0002-5710-7859", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b5228c807444dce92cb2bf0ab3106b3.json"}}, {"family": "Young", "given": "Kristen", "initials": "K", "orcid": "0000-0001-8570-2228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a27d6eed12724bb6ab180caab8fb1c49.json"}}, {"family": "Carmona", "given": "Loreto", "initials": "L", "orcid": "0000-0002-4401-2551", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/798721bfd6a14e2f95267a56c5750ebe.json"}}, {"family": "Cogo", "given": "Adriana Karina", "initials": "AK", "orcid": "0000-0002-9172-8317", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b41c8b74eb548259e966d268c88ce34.json"}}, {"family": "Duarte-Garc\u00eda", "given": "Al\u00ed", "initials": "A", "orcid": "0000-0003-1749-5719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77a5555c1b624ba49ee7c729be2aef95.json"}}, {"family": "Gossec", "given": "Laure", "initials": "L", "orcid": "0000-0002-4528-310X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be93914dbc9b4abb936cbcaf202de05f.json"}}, {"family": "Hasseli", "given": "Rebecca", "initials": "R", "orcid": "0000-0002-2982-8253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aac4e1f1ceab4e72bb816a40c2f80c44.json"}}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL", "orcid": "0000-0001-8242-9262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9ad49b088eb467ba6d1ca1559b88047.json"}}, {"family": "Langlois", "given": "Vincent", "initials": "V", "orcid": "0000-0002-4078-6306", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c85cfd8a1a5f45d5a73aa4c265493431.json"}}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S", "orcid": "0000-0002-8611-162X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73b17eb08d984421847f733b7a6a49d4.json"}}, {"family": "Malcata", "given": "Armando", "initials": "A"}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Schafer", "given": "Martin", "initials": "M", "orcid": "0000-0001-6487-3634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb2c617a7902440eb574fcb1141785ac.json"}}, {"family": "Scir\u00e8", "given": "Carlo Alberto", "initials": "CA", "orcid": "0000-0001-7451-0271", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76ebc6c1acb94b2780a38dc4e8aea708.json"}}, {"family": "Sigurdardottir", "given": "Valgerdur", "initials": "V", "orcid": "0000-0002-9907-4901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a451adf9d32f47b09bee7c8ed0eb22ab.json"}}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA", "orcid": "0000-0002-5556-4618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/192552e5e3d2435799e57111ea84502d.json"}}, {"family": "Strangfeld", "given": "Anja", "initials": "A"}, {"family": "Xavier", "given": "Ricardo M", "initials": "RM", "orcid": "0000-0001-6570-4533", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8c4f81afb3d469cb1a6bc19c42fd9e0.json"}}, {"family": "Bhana", "given": "Suleman", "initials": "S", "orcid": "0000-0003-3805-0946", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d9785cdfa2c4e99ae10bfd9b042be46.json"}}, {"family": "Gore-Massy", "given": "Monique", "initials": "M"}, {"family": "Hausmann", "given": "Jonathan", "initials": "J", "orcid": "0000-0003-0786-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d99dc166f48d4af7b8e46dc999c7444b.json"}}, {"family": "Liew", "given": "Jean W", "initials": "JW", "orcid": "0000-0002-8104-2450", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8099c4a02b6e4c4789fc9e6895abfb01.json"}}, {"family": "Sirotich", "given": "Emily", "initials": "E", "orcid": "0000-0002-7087-8543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c5dfbc359844544aa3684d916185fac.json"}}, {"family": "Sufka", "given": "Paul", "initials": "P", "orcid": "0000-0003-3131-7919", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/164a147aef724296ae7987d6b230c31c.json"}}, {"family": "Wallace", "given": "Zach", "initials": "Z", "orcid": "0000-0003-4708-7038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4cf68e5aa1444f8c8f8164fd0493a850.json"}}, {"family": "Machado", "given": "Pedro M", "initials": "PM", "orcid": "0000-0002-8411-7972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef40d1eea57946e4a37d2e92a02a47cd.json"}}, {"family": "Yazdany", "given": "Jinoos", "initials": "J", "orcid": "0000-0002-3508-4094", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62bbeb3392ce40d482da768af63f5d54.json"}}, {"family": "Grainger", "given": "Rebecca", "initials": "R", "orcid": "0000-0001-9201-8678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9d304e9e29a43a5a7a76679c002a876.json"}}, {"family": "Robinson", "given": "Philip C", "initials": "PC", "orcid": "0000-0002-3156-3418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/950b622d31724172817ccde09902d215.json"}}], "type": "journal article", "published": "2022-08-24", "journal": {"title": "ACR Open Rheumatol", "issn": "2578-5745", "issn-l": null}, "abstract": "To describe people with gout who were diagnosed with coronavirus disease 2019 (COVID-19) and hospitalized and to characterize their outcomes.\n\nData on patients with gout hospitalized for COVID-19 between March 12, 2020, and October 25, 2021, were extracted from the COVID-19 Global Rheumatology Alliance registry. Descriptive statistics were used to describe the demographics, comorbidities, medication exposures, and COVID-19 outcomes including oxygenation or ventilation support and death.\n\nOne hundred sixty-three patients with gout who developed COVID-19 and were hospitalized were included. The mean age was 63 years, and 85% were male. The majority of the group lived in the Western Pacific Region (35%) and North America (18%). Nearly half (46%) had two or more comorbidities, with hypertension (56%), cardiovascular disease (28%), diabetes mellitus (26%), chronic kidney disease (25%), and obesity (23%) being the most common. Glucocorticoids and colchicine were used pre-COVID-19 in 11% and 12% of the cohort, respectively. Over two thirds (68%) of the cohort required supplemental oxygen or ventilatory support during hospitalization. COVID-19-related death was reported in 16% of the overall cohort, with 73% of deaths documented in people with two or more comorbidities.\n\nThis cohort of people with gout and COVID-19 who were hospitalized had high frequencies of ventilatory support and death. This suggests that patients with gout who were hospitalized for COVID-19 may be at risk of poor outcomes, perhaps related to known risk factors for poor outcomes, such as age and presence of comorbidity.", "doi": "10.1002/acr2.11495", "pmid": "36000538", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-26T04:43:49.533Z", "modified": "2022-08-26T04:43:50.160Z"}, {"entity": "publication", "iuid": "41327e2709a34ff8b1b94bc0e9185e82", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41327e2709a34ff8b1b94bc0e9185e82.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41327e2709a34ff8b1b94bc0e9185e82"}}, "title": "Respiratory and systemic monocytes, dendritic cells and myeloid-derived suppressor cells in COVID-19: Implications for disease severity.", "authors": [{"family": "Falck-Jones", "given": "Sara", "initials": "S"}, {"family": "\u00d6sterberg", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A", "orcid": "0000-0001-6966-7039", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0c96bf27aca45f6b460a555c5425e2d.json"}}], "type": "journal article", "published": "2022-08-23", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null}, "abstract": "Since the beginning of the SARS-CoV-2 pandemic in 2020, researchers worldwide have made efforts to understand the mechanisms behind the varying range of COVID-19 disease severity. Since the respiratory tract is the site of infection, and immune cells differ depending on their anatomical location, studying blood is not sufficient to understand the full immunopathogenesis in patients with COVID-19. It is becoming increasingly clear that monocytes, dendritic cells (DCs) and monocytic myeloid-derived suppressor cells (M-MDSCs) are involved in the immunopathology of COVID-19 and may play important roles in determining disease severity. Patients with mild COVID-19 display an early antiviral (interferon) response in the nasopharynx, expansion of activated intermediate monocytes and low levels of M-MDSCs in blood. In contrast, patients with severe COVID-19 seem to lack an early efficient induction of interferons, and skew towards a more suppressive response in blood. This is characterized by downregulation of activation markers and decreased functional capacity of blood monocytes and DCs, reduced circulating DCs and increased levels of HLA-DRlo CD14+ M-MDSCs. These suppressive characteristics could potentially contribute to delayed T cell responses in severe COVID-19 cases. In contrast, airways of patients with severe COVID-19 display hyperinflammation with elevated levels of inflammatory monocytes and monocyte-derived macrophages, and reduced levels of tissue-resident alveolar macrophages. These monocyte-derived cells contribute to excess inflammation by producing cytokines and chemokines. Here, we review the current knowledge on the role of monocytes, DCs and M-MDSCs in COVID-19 and how alterations and the anatomical distribution of these cell populations may relate to disease severity. This article is protected by copyright. All rights reserved.", "doi": "10.1111/joim.13559", "pmid": "35996885", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2022-08-26T04:45:51.973Z", "modified": "2022-08-26T04:45:52.027Z"}, {"entity": "publication", "iuid": "ef5efbb16ed3439d97267aef0736031a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef5efbb16ed3439d97267aef0736031a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef5efbb16ed3439d97267aef0736031a"}}, "title": "Genetic predispositions to psychiatric disorders and the risk of COVID-19.", "authors": [{"family": "Chen", "given": "Wenwen", "initials": "W"}, {"family": "Zeng", "given": "Yu", "initials": "Y"}, {"family": "Suo", "given": "Chen", "initials": "C"}, {"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Chen", "given": "Yilong", "initials": "Y"}, {"family": "Hou", "given": "Can", "initials": "C"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "Sun", "given": "Yajing", "initials": "Y"}, {"family": "Qu", "given": "Yuanyuan", "initials": "Y"}, {"family": "Lu", "given": "Donghao", "initials": "D"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Song", "given": "Huan", "initials": "H", "orcid": "0000-0003-3845-8079", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2e35902226b407487330fc6c7368759.json"}}], "type": "journal article", "published": "2022-08-23", "journal": {"title": "BMC Med", "issn": "1741-7015", "volume": "20", "issue": "1", "pages": "314", "issn-l": null}, "abstract": "Whether a genetic predisposition to psychiatric disorders is associated with coronavirus disease 2019 (COVID-19) is unknown.\n\nOur analytic sample consisted of 287,123 white British participants in UK Biobank who were alive on 31 January 2020. We performed a genome-wide association study (GWAS) analysis for each psychiatric disorder (substance misuse, depression, anxiety, psychotic disorder, and stress-related disorders) in a randomly selected half of the study population (\"base dataset\"). For the other half (\"target dataset\"), the polygenic risk score (PRS) was calculated as a proxy of individuals' genetic predisposition to a given psychiatric phenotype using discovered genetic variants from the base dataset. Ascertainment of COVID-19 was based on the Public Health England dataset, inpatient hospital data, or death registers in UK Biobank. COVID-19 cases from hospitalization records or death records were considered \"severe cases.\" The association between the PRS for psychiatric disorders and COVID-19 risk was examined using logistic regression. We also repeated PRS analyses based on publicly available GWAS summary statistics.\n\nA total of 143,562 participants (including 10,868 COVID-19 cases) were used for PRS analyses. A higher genetic predisposition to psychiatric disorders was associated with an increased risk of any COVID-19 and severe COVID-19. The adjusted odds ratio (OR) for any COVID-19 was 1.07 (95% confidence interval [CI] 1.02-1.13) and 1.06 (95% CI 1.01-1.11) among individuals with a high genetic risk (above the upper tertile of the PRS) for substance misuse and depression, respectively, compared with individuals with a low genetic risk (below the lower tertile). Slightly higher ORs were noted for severe COVID-19, and similar result patterns were obtained in analyses based on publicly available GWAS summary statistics.\n\nOur findings suggest a potential role of genetic factors in the observed phenotypic association between psychiatric disorders and COVID-19. Our data underscore the need for increased medical surveillance for this vulnerable population during the COVID-19 pandemic.", "doi": "10.1186/s12916-022-02520-z", "pmid": "35999565", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12916-022-02520-z"}], "notes": [], "created": "2022-08-26T04:44:51.899Z", "modified": "2022-08-26T04:44:51.929Z"}, {"entity": "publication", "iuid": "c9f20a46bf7a480c9d2cafe1fe5582e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9f20a46bf7a480c9d2cafe1fe5582e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9f20a46bf7a480c9d2cafe1fe5582e2"}}, "title": "Diffuse alveolar damage patterns reflect the immunological and molecular heterogeneity in fatal COVID-19.", "authors": [{"family": "Erjef\u00e4lt", "given": "Jonas S", "initials": "JS"}, {"family": "de Souza Xavier Costa", "given": "Nat\u00e1lia", "initials": "N"}, {"family": "J\u00f6nsson", "given": "Jimmie", "initials": "J"}, {"family": "Cozzolino", "given": "Olga", "initials": "O"}, {"family": "Dantas", "given": "Katia Cristina", "initials": "KC"}, {"family": "Clausson", "given": "Carl-Magnus", "initials": "CM"}, {"family": "Siddhuraj", "given": "Premkumar", "initials": "P"}, {"family": "Lind\u00f6", "given": "Caroline", "initials": "C"}, {"family": "Alyamani", "given": "Manar", "initials": "M"}, {"family": "Lombardi", "given": "Suzete Cleusa Ferreira Spina", "initials": "SCFS"}, {"family": "Mendroni J\u00fanior", "given": "Alfredo", "initials": "A"}, {"family": "Antonangelo", "given": "Leila", "initials": "L"}, {"family": "Faria", "given": "Caroline Silv\u00e9rio", "initials": "CS"}, {"family": "Duarte-Neto", "given": "Amaro Nunes", "initials": "AN"}, {"family": "de Almeida Monteiro", "given": "Renata Aparecida", "initials": "RA"}, {"family": "Rebello Pinho", "given": "Jo\u00e3o Renato", "initials": "JR"}, {"family": "Gomes-Gouv\u00eaa", "given": "Michele Soares", "initials": "MS"}, {"family": "Verciano Pereira", "given": "Roberta", "initials": "R"}, {"family": "Monteiro", "given": "Jhonatas Sirino", "initials": "JS"}, {"family": "Setubal", "given": "Jo\u00e3o Carlos", "initials": "JC"}, {"family": "de Oliveira", "given": "Ellen Pierre", "initials": "EP"}, {"family": "Theodoro Filho", "given": "Jair", "initials": "J"}, {"family": "Sanden", "given": "Caroline", "initials": "C"}, {"family": "Orengo", "given": "Jamie M", "initials": "JM"}, {"family": "Sleeman", "given": "Matthew A", "initials": "MA"}, {"family": "da Silva", "given": "Luiz Fernando Ferraz", "initials": "LFF"}, {"family": "Saldiva", "given": "Paulo Hil\u00e1rio Nascimento", "initials": "PHN"}, {"family": "Dolhnikoff", "given": "Marisa", "initials": "M"}, {"family": "Mauad", "given": "Thais", "initials": "T"}], "type": "journal article", "published": "2022-08-23", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "volume": "83", "pages": "104229", "issn-l": null}, "abstract": "Severe COVID-19 lung disease exhibits a high degree of spatial and temporal heterogeneity, with different histological features coexisting within a single individual. It is important to capture the disease complexity to support patient management and treatment strategies. We provide spatially decoded analyses on the immunopathology of diffuse alveolar damage (DAD) patterns and factors that modulate immune and structural changes in fatal COVID-19.\n\nWe spatially quantified the immune and structural cells in exudative, intermediate, and advanced DAD through multiplex immunohistochemistry in autopsy lung tissue of 18 COVID-19 patients. Cytokine profiling, viral, bacteria, and fungi detection, and transcriptome analyses were performed.\n\nSpatial DAD progression was associated with expansion of immune cells, macrophages, CD8+ T cells, fibroblasts, and (lymph)angiogenesis. Viral load correlated positively with exudative DAD and negatively with disease/hospital length. In all cases, enteric bacteria were isolated, and Candida parapsilosis in eight cases. Cytokines correlated mainly with macrophages and CD8+T cells. Pro-coagulation and acute repair were enriched pathways in exudative DAD whereas intermediate/advanced DAD had a molecular profile of elevated humoral and innate immune responses and extracellular matrix production.\n\nUnraveling the spatial and molecular immunopathology of COVID-19 cases exposes the responses to SARS-CoV-2-induced exudative DAD and subsequent immune-modulatory and remodeling changes in proliferative/advanced DAD that occur side-by-side together with secondary infections in the lungs. These complex features have important implications for disease management and the development of novel treatments.\n\nCNPq, Bill and Melinda Gates Foundation, HC-Convida, FAPESP, Regeneron Pharmaceuticals, and the Swedish Heart & Lung Foundation.", "doi": "10.1016/j.ebiom.2022.104229", "pmid": "36027872", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2352-3964(22)00411-X"}, {"db": "pmc", "key": "PMC9398470"}], "notes": [], "created": "2022-09-12T19:15:23.961Z", "modified": "2022-09-12T19:15:23.966Z"}, {"entity": "publication", "iuid": "d616ec14309e4023a914ce720f7f17c4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d616ec14309e4023a914ce720f7f17c4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d616ec14309e4023a914ce720f7f17c4"}}, "title": "Clinical risk factors of adverse outcomes among women with COVID-19 in the pregnancy and postpartum period: A sequential, prospective meta-analysis.", "authors": [{"family": "Smith", "given": "Emily R", "initials": "ER"}, {"family": "Oakley", "given": "Erin", "initials": "E"}, {"family": "Grandner", "given": "Gargi Wable", "initials": "GW"}, {"family": "Rukundo", "given": "Gordon", "initials": "G"}, {"family": "Farooq", "given": "Fouzia", "initials": "F"}, {"family": "Ferguson", "given": "Kacey", "initials": "K"}, {"family": "Baumann", "given": "Sasha", "initials": "S"}, {"family": "Waldorf", "given": "Kristina Adams", "initials": "KA"}, {"family": "Afshar", "given": "Yalda", "initials": "Y"}, {"family": "Ahlberg", "given": "Mia", "initials": "M"}, {"family": "Ahmadzia", "given": "Homa", "initials": "H"}, {"family": "Akelo", "given": "Victor", "initials": "V"}, {"family": "Aldrovandi", "given": "Grace", "initials": "G"}, {"family": "Bevilacqua", "given": "Elisa", "initials": "E"}, {"family": "Bracero", "given": "Nabal", "initials": "N"}, {"family": "Brandt", "given": "Justin S", "initials": "JS"}, {"family": "Broutet", "given": "Natalie", "initials": "N"}, {"family": "Carrillo", "given": "Jorge", "initials": "J"}, {"family": "Conry", "given": "Jeanne", "initials": "J"}, {"family": "Cosmi", "given": "Erich", "initials": "E"}, {"family": "Crispi", "given": "Fatima", "initials": "F"}, {"family": "Crovetto", "given": "Francesca", "initials": "F"}, {"family": "Gil", "given": "Maria Del Mar", "initials": "MDM"}, {"family": "Delgado-L\u00f3pez", "given": "Camille", "initials": "C"}, {"family": "Divakar", "given": "Hema", "initials": "H"}, {"family": "Driscoll", "given": "Amanda J", "initials": "AJ"}, {"family": "Favre", "given": "Guillaume", "initials": "G"}, {"family": "Buhigas", "given": "Irene Fernandez", "initials": "IF"}, {"family": "Flaherman", "given": "Valerie", "initials": "V"}, {"family": "Gale", "given": "Christopher", "initials": "C"}, {"family": "Godwin", "given": "Christine L", "initials": "CL"}, {"family": "Gottlieb", "given": "Sami", "initials": "S"}, {"family": "Gratac\u00f3s", "given": "Eduard", "initials": "E"}, {"family": "He", "given": "Siran", "initials": "S"}, {"family": "Hernandez", "given": "Olivia", "initials": "O"}, {"family": "Jones", "given": "Stephanie", "initials": "S"}, {"family": "Joshi", "given": "Sheetal", "initials": "S"}, {"family": "Kalafat", "given": "Erkan", "initials": "E"}, {"family": "Khagayi", "given": "Sammy", "initials": "S"}, {"family": "Knight", "given": "Marian", "initials": "M"}, {"family": "Kotloff", "given": "Karen", "initials": "K"}, {"family": "Lanzone", "given": "Antonio", "initials": "A"}, {"family": "Longo", "given": "Valentina Laurita", "initials": "VL"}, {"family": "Le Doare", "given": "Kirsty", "initials": "K"}, {"family": "Lees", "given": "Christoph", "initials": "C"}, {"family": "Litman", "given": "Ethan", "initials": "E"}, {"family": "Lokken", "given": "Erica M", "initials": "EM"}, {"family": "Madhi", "given": "Shabir A", "initials": "SA"}, {"family": "Magee", "given": "Laura A", "initials": "LA"}, {"family": "Martinez-Portilla", "given": "Raigam Jafet", "initials": "RJ"}, {"family": "Metz", "given": "Torri D", "initials": "TD"}, {"family": "Miller", "given": "Emily S", "initials": "ES"}, {"family": "Money", "given": "Deborah", "initials": "D"}, {"family": "Moungmaithong", "given": "Sakita", "initials": "S"}, {"family": "Mullins", "given": "Edward", "initials": "E"}, {"family": "Nachega", "given": "Jean B", "initials": "JB"}, {"family": "Nunes", "given": "Marta C", "initials": "MC"}, {"family": "Onyango", "given": "Dickens", "initials": "D"}, {"family": "Panchaud", "given": "Alice", "initials": "A"}, {"family": "Poon", "given": "Liona C", "initials": "LC"}, {"family": "Raiten", "given": "Daniel", "initials": "D"}, {"family": "Regan", "given": "Lesley", "initials": "L"}, {"family": "Sahota", "given": "Daljit", "initials": "D"}, {"family": "Sakowicz", "given": "Allie", "initials": "A"}, {"family": "Sanin-Blair", "given": "Jose", "initials": "J"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}, {"family": "Temmerman", "given": "Marleen", "initials": "M"}, {"family": "Thorson", "given": "Anna", "initials": "A"}, {"family": "Thwin", "given": "Soe Soe", "initials": "SS"}, {"family": "Tippett Barr", "given": "Beth A", "initials": "BA"}, {"family": "Tolosa", "given": "Jorge E", "initials": "JE"}, {"family": "Tug", "given": "Niyazi", "initials": "N"}, {"family": "Valencia-Prado", "given": "Miguel", "initials": "M"}, {"family": "Visentin", "given": "Silvia", "initials": "S"}, {"family": "von Dadelszen", "given": "Peter", "initials": "P"}, {"family": "Whitehead", "given": "Clare", "initials": "C"}, {"family": "Wood", "given": "Mollie", "initials": "M"}, {"family": "Yang", "given": "Huixia", "initials": "H"}, {"family": "Zavala", "given": "Rebecca", "initials": "R"}, {"family": "Tielsch", "given": "James M", "initials": "JM"}], "type": "journal article", "published": "2022-08-23", "journal": {"title": "Am J Obstet Gynecol", "issn": "1097-6868", "issn-l": null}, "abstract": "This sequential, prospective meta-analysis (sPMA) sought to identify risk factors among pregnant and postpartum women with COVID-19 for adverse outcomes related to: disease severity, maternal morbidities, neonatal mortality and morbidity, adverse birth outcomes.\n\nWe prospectively invited study investigators to join the sPMA via professional research networks beginning in March 2020.\n\nEligible studies included those recruiting at least 25 consecutive cases of COVID-19 in pregnancy within a defined catchment area.\n\nWe included individual patient data from 21 participating studies. Data quality was assessed, and harmonized variables for risk factors and outcomes were constructed. Duplicate cases were removed. Pooled estimates for the absolute and relative risk of adverse outcomes comparing those with and without each risk factor were generated using a two-stage meta-analysis.\n\nWe collected data from 33 countries and territories, including 21,977 cases of SARS-CoV-2 infection in pregnancy or postpartum. We found that women with comorbidities (pre-existing diabetes, hypertension, cardiovascular disease) versus those without were at higher risk for COVID-19 severity and pregnancy health outcomes (fetal death, preterm birth, low birthweight). Participants with COVID-19 and HIV were 1.74 times (95% CI: 1.12, 2.71) more likely to be admitted to the ICU. Pregnant women who were underweight before pregnancy were at higher risk of ICU admission (RR 5.53, 95% CI: 2.27, 13.44), ventilation (RR 9.36, 95% CI: 3.87, 22.63), and pregnancy-related death (RR 14.10, 95% CI: 2.83, 70.36). Pre-pregnancy obesity was also a risk factor for severe COVID-19 outcomes including ICU admission (RR 1.81, 95% CI: 1.26,2.60), ventilation (RR 2.05, 95% CI: 1.20,3.51), any critical care (RR 1.89, 95% CI: 1.28,2.77), and pneumonia (RR 1.66, 95% CI: 1.18,2.33). Anemic pregnant women with COVID-19 also had increased risk of ICU admission (RR 1.63, 95% CI: 1.25, 2.11) and death (RR 2.36, 95% CI: 1.15, 4.81).\n\nWe found that pregnant women with comorbidities including diabetes, hypertension, and cardiovascular disease were at increased risk for severe COVID-19-related outcomes, maternal morbidities, and adverse birth outcomes. We also identified several less commonly-known risk factors, including HIV infection, pre-pregnancy underweight, and anemia. Although pregnant women are already considered a high-risk population, special priority for prevention and treatment should be given to pregnant women with these additional risk factors.", "doi": "10.1016/j.ajog.2022.08.038", "pmid": "36027953", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0002-9378(22)00680-9"}, {"db": "pmc", "key": "PMC9398561"}], "notes": [], "created": "2022-09-12T19:15:47.556Z", "modified": "2022-09-12T19:15:47.562Z"}, {"entity": "publication", "iuid": "255dd60f402c4f3da278ba0e771bd03f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/255dd60f402c4f3da278ba0e771bd03f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/255dd60f402c4f3da278ba0e771bd03f"}}, "title": "The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force.", "authors": [{"family": "Wang", "given": "Qingbo S", "initials": "QS"}, {"family": "Edahiro", "given": "Ryuya", "initials": "R"}, {"family": "Namkoong", "given": "Ho", "initials": "H"}, {"family": "Hasegawa", "given": "Takanori", "initials": "T"}, {"family": "Shirai", "given": "Yuya", "initials": "Y"}, {"family": "Sonehara", "given": "Kyuto", "initials": "K"}, {"family": "Tanaka", "given": "Hiromu", "initials": "H"}, {"family": "Lee", "given": "Ho", "initials": "H"}, {"family": "Saiki", "given": "Ryunosuke", "initials": "R", "orcid": "0000-0001-6984-7187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd5bae576b614b1f9e27c3975f2f72a2.json"}}, {"family": "Hyugaji", "given": "Takayoshi", "initials": "T"}, {"family": "Shimizu", "given": "Eigo", "initials": "E"}, {"family": "Katayama", "given": "Kotoe", "initials": "K", "orcid": "0000-0002-3966-1231", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68f93c3d200e45cea3eaea3a1758f0af.json"}}, {"family": "Kanai", "given": "Masahiro", "initials": "M", "orcid": "0000-0001-5165-4408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01d858a30cea453d91cedab1fd5c8494.json"}}, {"family": "Naito", "given": "Tatsuhiko", "initials": "T", "orcid": "0000-0002-2779-4600", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b0897a4c92b4ca781c81fc0d5520385.json"}}, {"family": "Sasa", "given": "Noah", "initials": "N"}, {"family": "Yamamoto", "given": "Kenichi", "initials": "K", "orcid": "0000-0001-9594-7050", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d494d739ff8469c9f6def67c94cb3ef.json"}}, {"family": "Kato", "given": "Yasuhiro", "initials": "Y"}, {"family": "Morita", "given": "Takayoshi", "initials": "T"}, {"family": "Takahashi", "given": "Kazuhisa", "initials": "K", "orcid": "0000-0001-5749-4118", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d5ac9fceb6f47ffabede76f02a183e4.json"}}, {"family": "Harada", "given": "Norihiro", "initials": "N"}, {"family": "Naito", "given": "Toshio", "initials": "T"}, {"family": "Hiki", "given": "Makoto", "initials": "M"}, {"family": "Matsushita", "given": "Yasushi", "initials": "Y"}, {"family": "Takagi", "given": "Haruhi", "initials": "H"}, {"family": "Ichikawa", "given": "Masako", "initials": "M"}, {"family": "Nakamura", "given": "Ai", "initials": "A"}, {"family": "Harada", "given": "Sonoko", "initials": "S"}, {"family": "Sandhu", "given": "Yuuki", "initials": "Y"}, {"family": "Kabata", "given": "Hiroki", "initials": "H"}, {"family": "Masaki", "given": "Katsunori", "initials": "K"}, {"family": "Kamata", "given": "Hirofumi", "initials": "H"}, {"family": "Ikemura", "given": "Shinnosuke", "initials": "S"}, {"family": "Chubachi", "given": "Shotaro", "initials": "S"}, {"family": "Okamori", "given": "Satoshi", "initials": "S"}, {"family": "Terai", "given": "Hideki", "initials": "H", "orcid": "0000-0002-1118-1930", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d4b3da553c9463a84199024fbe1c41b.json"}}, {"family": "Morita", "given": "Atsuho", "initials": "A"}, {"family": "Asakura", "given": "Takanori", "initials": "T", "orcid": "0000-0003-3122-6937", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2031e5d0b29849d6ba08e174e7da4834.json"}}, {"family": "Sasaki", "given": "Junichi", "initials": "J"}, {"family": "Morisaki", "given": "Hiroshi", "initials": "H"}, {"family": "Uwamino", "given": "Yoshifumi", "initials": "Y"}, {"family": "Nanki", "given": "Kosaku", "initials": "K"}, {"family": "Uchida", "given": "Sho", "initials": "S"}, {"family": "Uno", "given": "Shunsuke", "initials": "S"}, {"family": "Nishimura", "given": "Tomoyasu", "initials": "T"}, {"family": "Ishiguro", "given": "Takashri", "initials": "T"}, {"family": "Isono", "given": "Taisuke", "initials": "T"}, {"family": "Shibata", "given": "Shun", "initials": "S"}, {"family": "Matsui", "given": "Yuma", "initials": "Y"}, {"family": "Hosoda", "given": "Chiaki", "initials": "C"}, {"family": "Takano", "given": "Kenji", "initials": "K"}, {"family": "Nishida", "given": "Takashi", "initials": "T"}, {"family": "Kobayashi", "given": "Yoichi", "initials": "Y"}, {"family": "Takaku", "given": "Yotaro", "initials": "Y"}, {"family": "Takayanagi", "given": "Noboru", "initials": "N"}, {"family": "Ueda", "given": "Soichiro", "initials": "S"}, {"family": "Tada", "given": "Ai", "initials": "A"}, {"family": "Miyawaki", "given": "Masayoshi", "initials": "M"}, {"family": "Yamamoto", "given": "Masaomi", "initials": "M"}, {"family": "Yoshida", "given": "Eriko", "initials": "E"}, {"family": "Hayashi", "given": "Reina", "initials": "R"}, {"family": "Nagasaka", "given": "Tomoki", "initials": "T"}, {"family": "Arai", "given": "Sawako", "initials": "S"}, {"family": "Kaneko", "given": "Yutaro", "initials": "Y"}, {"family": "Sasaki", "given": "Kana", "initials": "K"}, {"family": "Tagaya", "given": "Etsuko", "initials": "E"}, {"family": "Kawana", "given": "Masatoshi", "initials": "M"}, {"family": "Arimura", "given": "Ken", "initials": "K"}, {"family": "Takahashi", "given": "Kunihiko", "initials": "K"}, {"family": "Anzai", "given": "Tatsuhiko", "initials": "T"}, {"family": "Ito", "given": "Satoshi", "initials": "S"}, {"family": "Endo", "given": "Akifumi", "initials": "A"}, {"family": "Uchimura", "given": "Yuji", "initials": "Y"}, {"family": "Miyazaki", "given": "Yasunari", "initials": "Y", "orcid": "0000-0002-9073-9815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cabd9b972ca24453957c822589b9bebd.json"}}, {"family": "Honda", "given": "Takayuki", "initials": "T"}, {"family": "Tateishi", "given": "Tomoya", "initials": "T"}, {"family": "Tohda", "given": "Shuji", "initials": "S"}, {"family": "Ichimura", "given": "Naoya", "initials": "N"}, {"family": "Sonobe", "given": "Kazunari", "initials": "K"}, {"family": "Sassa", "given": "Chihiro Tani", "initials": "CT"}, {"family": "Nakajima", "given": "Jun", "initials": "J"}, {"family": "Nakano", "given": "Yasushi", "initials": "Y"}, {"family": "Nakajima", "given": "Yukiko", "initials": "Y"}, {"family": "Anan", "given": "Ryusuke", "initials": "R"}, {"family": "Arai", "given": "Ryosuke", "initials": "R"}, {"family": "Kurihara", "given": "Yuko", "initials": "Y"}, {"family": "Harada", "given": "Yuko", "initials": "Y"}, {"family": "Nishio", "given": "Kazumi", "initials": "K"}, {"family": "Ueda", "given": "Tetsuya", "initials": "T"}, {"family": "Azuma", "given": "Masanori", "initials": "M"}, {"family": "Saito", "given": "Ryuichi", "initials": "R"}, {"family": "Sado", "given": "Toshikatsu", "initials": "T"}, {"family": "Miyazaki", "given": "Yoshimune", "initials": "Y"}, {"family": "Sato", "given": "Ryuichi", "initials": "R"}, {"family": "Haruta", "given": "Yuki", "initials": "Y"}, {"family": "Nagasaki", "given": "Tadao", "initials": "T"}, {"family": "Yasui", "given": "Yoshinori", "initials": "Y"}, {"family": "Hasegawa", "given": "Yoshinori", "initials": "Y"}, {"family": "Mutoh", "given": "Yoshikazu", "initials": "Y"}, {"family": "Kimura", "given": "Tomoki", "initials": "T"}, {"family": "Sato", "given": "Tomonori", "initials": "T"}, {"family": "Takei", "given": "Reoto", "initials": "R"}, {"family": "Hagimoto", "given": "Satoshi", "initials": "S"}, {"family": "Noguchi", "given": "Yoichiro", "initials": "Y"}, {"family": "Yamano", "given": "Yasuhiko", "initials": "Y"}, {"family": "Sasano", "given": "Hajime", "initials": "H"}, {"family": "Ota", "given": "Sho", "initials": "S"}, {"family": "Nakamori", "given": "Yasushi", "initials": "Y"}, {"family": "Yoshiya", "given": "Kazuhisa", "initials": "K"}, {"family": "Saito", "given": "Fukuki", "initials": "F"}, {"family": "Yoshihara", "given": "Tomoyuki", "initials": "T"}, {"family": "Wada", "given": "Daiki", "initials": "D"}, {"family": "Iwamura", "given": "Hiromu", "initials": "H"}, {"family": "Kanayama", "given": "Syuji", "initials": "S"}, {"family": "Maruyama", "given": "Shuhei", "initials": "S"}, {"family": "Yoshiyama", "given": "Takashi", "initials": "T"}, {"family": "Ohta", "given": "Ken", "initials": "K"}, {"family": "Kokuto", "given": "Hiroyuki", "initials": "H"}, {"family": "Ogata", "given": "Hideo", "initials": "H"}, {"family": "Tanaka", "given": "Yoshiaki", "initials": "Y"}, {"family": "Arakawa", "given": "Kenichi", "initials": "K"}, {"family": "Shimoda", "given": "Masafumi", "initials": "M"}, {"family": "Osawa", "given": "Takeshi", "initials": "T"}, {"family": "Tateno", "given": "Hiroki", "initials": "H"}, {"family": "Hase", "given": "Isano", "initials": "I"}, {"family": "Yoshida", "given": "Shuichi", "initials": "S"}, {"family": "Suzuki", "given": "Shoji", "initials": "S"}, {"family": "Kawada", "given": "Miki", "initials": "M"}, {"family": "Horinouchi", "given": "Hirohisa", "initials": "H"}, {"family": "Saito", "given": "Fumitake", "initials": "F"}, {"family": "Mitamura", "given": "Keiko", "initials": "K"}, {"family": "Hagihara", "given": "Masao", "initials": "M"}, {"family": "Ochi", "given": "Junichi", "initials": "J"}, {"family": "Uchida", "given": "Tomoyuki", "initials": "T"}, {"family": "Baba", "given": "Rie", "initials": "R"}, {"family": "Arai", "given": "Daisuke", "initials": "D"}, {"family": "Ogura", "given": "Takayuki", "initials": "T"}, {"family": "Takahashi", "given": "Hidenori", "initials": "H"}, {"family": "Hagiwara", "given": "Shigehiro", "initials": "S"}, {"family": "Nagao", "given": "Genta", "initials": "G"}, {"family": "Konishi", "given": "Shunichiro", "initials": "S"}, {"family": "Nakachi", "given": "Ichiro", "initials": "I"}, {"family": "Murakami", "given": "Koji", "initials": "K"}, {"family": "Yamada", "given": "Mitsuhiro", "initials": "M", "orcid": "0000-0002-0832-1939", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d3444abf3314d299e9273003635c06a.json"}}, {"family": "Sugiura", "given": "Hisatoshi", "initials": "H", "orcid": 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"researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34661820735e4853b72794b693577d25.json"}}, {"family": "Ishii", "given": "Makoto", "initials": "M", "orcid": "0000-0003-4396-1664", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/baeffc7d32584e36a16ccd0d1d39aeaa.json"}}, {"family": "Koike", "given": "Ryuji", "initials": "R"}, {"family": "Kitagawa", "given": "Yuko", "initials": "Y"}, {"family": "Kimura", "given": "Akinori", "initials": "A"}, {"family": "Imoto", "given": "Seiya", "initials": "S", "orcid": "0000-0002-2989-308X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f199938ef404db986b6697e05d41d56.json"}}, {"family": "Miyano", "given": "Satoru", "initials": "S"}, {"family": "Ogawa", "given": "Seishi", "initials": "S", "orcid": "0000-0002-7778-5374", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/794485862ba3443294803c120ae16e3a.json"}}, {"family": "Kanai", "given": "Takanori", "initials": "T", "orcid": "0000-0002-1466-4532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c701a687e494d90b9fc18a75a909a28.json"}}, {"family": "Fukunaga", "given": "Koichi", "initials": "K"}, {"family": "Okada", "given": "Yukinori", "initials": "Y", "orcid": "0000-0002-0311-8472", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/180d7682259f44da968366b41662b959.json"}}], "type": "journal article", "published": "2022-08-22", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "4830", "issn-l": "2041-1723"}, "abstract": "Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection.", "doi": "10.1038/s41467-022-32276-2", "pmid": "35995775", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-022-32276-2"}, {"db": "pmc", "key": "PMC9395416"}], "notes": [], "created": "2022-09-12T19:06:01.529Z", "modified": "2022-09-12T19:06:02.312Z"}, {"entity": "publication", "iuid": "ab648c6fe66743d389ec34b288e73dcb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ab648c6fe66743d389ec34b288e73dcb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ab648c6fe66743d389ec34b288e73dcb"}}, "title": "Cross-cultural equivalence of parental ratings of child difficulties during the pandemic: Findings from a six-site study.", "authors": [{"family": "Foley", "given": "Sarah", "initials": "S", "orcid": "0000-0001-8900-9885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2661df30ae94fc296211e848a02a0b9.json"}}, {"family": "Ronchi", "given": "Luca", "initials": "L", "orcid": "0000-0001-7723-9376", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1e89c62c76f443288c1df82f370cdf4.json"}}, {"family": "Lecce", "given": "Serena", "initials": "S", "orcid": "0000-0002-2745-3574", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1fd6450ec02142fb9640a78dcd7c9f83.json"}}, {"family": "Feng", "given": "Xin", "initials": "X", "orcid": "0000-0003-4046-5374", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0a3090940da46f081c5f017dffdea0d.json"}}, {"family": "Chan", "given": "Meingold H M", "initials": "MHM", "orcid": "0000-0001-9108-2504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5d5d31a0104485db02d180a25586206.json"}}, {"family": "Hughes", "given": "Claire", "initials": "C", "orcid": "0000-0003-2545-3025", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7032b296d5145428c9ac304f5a80378.json"}}], "type": "journal article", "published": "2022-08-22", "journal": {"title": "Int J Methods Psychiatr Res", "issn": "1557-0657", "pages": "e1933", "issn-l": null}, "abstract": "The Strengths and Difficulties Questionnaire (SDQ) has been shown to be invariant across informants, developmental stage and settings, but tests of cross-cultural equivalence are limited to adolescents' self-reports. The COVID-19 pandemic makes this gap particularly pertinent, given the need to understand whether distinct government approaches (e.g., school closures) are uniquely associated with variability in children's psychosocial outcomes and the reliance on parents' ratings for young children.\n\nWithin a Confirmatory Factor Analysis framework, we tested the cross-cultural measurement invariance of the SDQ across six countries: Australia, China, Italy, Sweden, the United Kingdom and USA, using a sample of 1761 parents of 3- to 8-year-olds (M = 5.76, SD = 1.09).\n\nA five-factors model showed good fit to the data and partial cross-cultural scalar invariance. In this sample, Swedish parents reported the fewest peer problems (Cohen's d = 0.950) and the highest prosocial scores (Cohen's d = 0.547), whilst British parents reported the greatest child emotional (Cohen's d = 0.412) and hyperactivity problems (Cohen's d = 0.535).\n\nThe present results indicate that the parent-version of the SDQ is appropriate for use and comparison across different contexts during the pandemic.", "doi": "10.1002/mpr.1933", "pmid": "35994374", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:59:43.015Z", "modified": "2022-09-12T18:59:43.208Z"}, {"entity": "publication", "iuid": "239a6b95cd38479fb8bf23f47400d393", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/239a6b95cd38479fb8bf23f47400d393.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/239a6b95cd38479fb8bf23f47400d393"}}, "title": "COVID-19 Modeling Outcome versus Reality in Sweden.", "authors": [{"family": "Carlsson", "given": "Marcus", "initials": "M", "orcid": "0000-0002-3761-9072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9492f80f98584a4c949a0114fb44ef71.json"}}, {"family": "S\u00f6derberg-Naucl\u00e9r", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-8955-3610", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f10026ba9a64bfea2fc49de969cdde9.json"}}], "type": "journal article", "published": "2022-08-22", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "8", "issn-l": "1999-4915"}, "abstract": "It has been very difficult to predict the development of the COVID-19 pandemic based on mathematical models for the spread of infectious diseases, and due to major non-pharmacological interventions (NPIs), it is still unclear to what extent the models would have fit reality in a \"do nothing\" scenario. To shed light on this question, the case of Sweden during the time frame from autumn 2020 to spring 2021 is particularly interesting, since the NPIs were relatively minor and only marginally updated. We found that state of the art models are significantly overestimating the spread, unless we assume that social interactions significantly decrease continuously throughout the time frame, in a way that does not correlate well with Google-mobility data nor updates to the NPIs or public holidays. This leads to the question of whether modern SEIR-type mathematical models are unsuitable for modeling the spread of SARS-CoV-2 in the human population, or whether some particular feature of SARS-CoV-2 dampened the spread. We show that, by assuming a certain level of pre-immunity to SARS-CoV-2, we obtain an almost perfect data-fit, and discuss what factors could cause pre-immunity in the mathematical models. In this scenario, a form of herd-immunity under the given restrictions was reached twice (first against the Wuhan-strain and then against the alpha-strain), and the ultimate decline in cases was due to depletion of susceptibles rather than the vaccination campaign.", "doi": "10.3390/v14081840", "pmid": "36016462", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9415753"}, {"db": "pii", "key": "v14081840"}], "notes": [], "created": "2022-09-12T19:14:03.232Z", "modified": "2023-07-13T11:29:53.833Z"}, {"entity": "publication", "iuid": "b6de4fc9b0434827b7ca222118639d0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b6de4fc9b0434827b7ca222118639d0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b6de4fc9b0434827b7ca222118639d0e"}}, "title": "Response to Frequency of new seizures after SARS-CoV-2 infections may depend on the length of follow-up.", "authors": [{"family": "Westman", "given": "Gabriel", "initials": "G"}, {"family": "Zelano", "given": "Johan", "initials": "J"}], "type": "letter", "published": "2022-08-20", "journal": {"title": "Seizure", "issn": "1532-2688", "issn-l": null}, "abstract": null, "doi": "10.1016/j.seizure.2022.08.006", "pmid": "36030113", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1059-1311(22)00185-6"}, {"db": "pmc", "key": "PMC9391083"}], "notes": [], "created": "2022-10-07T12:40:23.381Z", "modified": "2022-10-07T12:40:23.397Z"}, {"entity": "publication", "iuid": "1091fb0317e6482fa445eb910829a150", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1091fb0317e6482fa445eb910829a150.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1091fb0317e6482fa445eb910829a150"}}, "title": "Comparison of SARS-CoV-2 spike RNA sequences in feces and nasopharynx indicates intestinal replication.", "authors": [{"family": "Beck-Friis", "given": "Thomas", "initials": "T"}, {"family": "K\u00e4rmander", "given": "Ambj\u00f6rn", "initials": "A"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Wang", "given": "Hao", "initials": "H"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Norder", "given": "Hel\u00e9ne", "initials": "H"}], "type": "journal article", "published": "2022-08-20", "journal": {"title": "Gut Pathog", "issn": "1757-4749", "volume": "14", "issue": "1", "pages": "35", "issn-l": null}, "abstract": "Little is known of possible selection and replication of SARS-CoV-2 in the intestines and if viral load in feces is associated with severity of disease. Therefore, sequence variations of the spike region in strains collected from feces and nasopharynx (NPH) from the same patients were compared. It was also investigated whether viral load in feces related to severity of COVID-19 in hospitalized patients.\n\nSARS-CoV-2 RNA was found in 88 (79%) fecal samples from 112 patients. The complete spike region could be sequenced in 15 fecal and 14 NPH samples. Fourteen Alpha-variants and one Beta-variant of SARS-CoV-2 were identified. The majority of the viral genetic variants (viral populations) in two fecal samples, but none in NPH, had a reversion of the H69/V70 amino acid deletion normally seen in the Alpha variants. Nine fecal samples contained up to nine minority variants, each which may constitute a separate viral population. Five NPH samples had one genetic variant each, and one NPH sample contained nine minority populations of SARS-CoV-2 spike genes.\n\nThe higher genomic diversity of SARS-CoV-2 in feces compared to NPH, and the reversion of the H69/V70 deletion in Alpha variants from feces indicate a selection of viral strains and replication of SARS-CoV-2 in the gastrointestinal tract.", "doi": "10.1186/s13099-022-00509-w", "pmid": "35987708", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13099-022-00509-w"}, {"db": "pmc", "key": "PMC9392503"}], "notes": [], "created": "2022-09-12T18:48:29.511Z", "modified": "2022-09-12T18:48:29.537Z"}, {"entity": "publication", "iuid": "1fa3baf6ba384548a6d4e9676212cd2b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1fa3baf6ba384548a6d4e9676212cd2b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1fa3baf6ba384548a6d4e9676212cd2b"}}, "title": "COVID-19 and Politically Motivated Reasoning.", "authors": [{"family": "Maguire", "given": "Allegra", "initials": "A"}, {"family": "Persson", "given": "Emil", "initials": "E", "orcid": "0000-0003-2994-0541", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5722c7a43dbc4303859f72218a6739da.json"}}, {"family": "V\u00e4stfj\u00e4ll", "given": "Daniel", "initials": "D"}, {"family": "Tingh\u00f6g", "given": "Gustav", "initials": "G", "orcid": "0000-0002-8159-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c4dcebfe7b0425182298cf35259223c.json"}}], "type": "journal article", "published": "2022-08-20", "journal": {"title": "Med Decis Making", "issn": "1552-681X", "issn-l": null, "volume": null, "issue": null, "pages": "272989X221118078"}, "abstract": "During the COVID-19 pandemic, the world witnessed a partisan segregation of beliefs toward the global health crisis and its management. Politically motivated reasoning, the tendency to interpret information in accordance with individual motives to protect valued beliefs rather than objectively considering the facts, could represent a key process involved in the polarization of attitudes. The objective of this study was to explore politically motivated reasoning when participants assess information regarding COVID-19.\r\n\r\nWe carried out a preregistered online experiment using a diverse sample (N = 1500) from the United States. Both Republicans and Democrats assessed the same COVID-19-related information about the health effects of lockdowns, social distancing, vaccination, hydroxychloroquine, and wearing face masks.\r\n\r\nAt odds with our prestated hypothesis, we found no evidence in line with politically motivated reasoning when interpreting numerical information about COVID-19. Moreover, we found no evidence supporting the idea that numeric ability or cognitive sophistication bolster politically motivated reasoning in the case of COVID-19. Instead, our findings suggest that participants base their assessment on prior beliefs of the matter.\r\n\r\nOur findings suggest that politically polarized attitudes toward COVID-19 are more likely to be driven by lack of reasoning than politically motivated reasoning-a finding that opens potential avenues for combating political polarization about important health care topics.\r\n\r\nParticipants assessed numerical information regarding the effect of different COVID-19 policies.We found no evidence in line with politically motivated reasoning when interpreting numerical information about COVID-19.Participants tend to base their assessment of COVID-19-related facts on prior beliefs of the matter.Politically polarized attitudes toward COVID-19 are more a result of lack of thinking than partisanship.", "doi": "10.1177/0272989X221118078", "pmid": "35993415", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:53:25.098Z", "modified": "2022-11-09T08:37:33.249Z"}, {"entity": "publication", "iuid": "673f5eb1917b413d908fd5821b9cf280", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/673f5eb1917b413d908fd5821b9cf280.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/673f5eb1917b413d908fd5821b9cf280"}}, "title": "Pulmonary Embolism in Post-CoviD-19 Patients, a Literature Review: Red Flag for Increased Awareness?", "authors": [{"family": "Mouzarou", "given": "Angeliki", "initials": "A", "orcid": "0000-0002-6687-5075", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07a30f36479e44bc937fa4bd97026313.json"}}, {"family": "Ioannou", "given": "Maria", "initials": "M"}, {"family": "Leonidou", "given": "Elena", "initials": "E"}, {"family": "Chaziri", "given": "Ioanna", "initials": "I"}], "type": "journal article", "published": "2022-08-19", "journal": {"title": "SN Compr Clin Med", "issn": "2523-8973", "volume": "4", "issue": "1", "pages": "190", "issn-l": null}, "abstract": "Although COVID-19 was primarily considered a respiratory illness, rapidly accumulating data suggest that COVID-19 is associated with a high incidence of venous thromboembolic complications. The primary objective of this review article was to reveal whether we need to increase awareness of pulmonary embolism in the period following the COVID-19 infection given that the epidemiologic facts are still poor. A literature search and a critical review of the collected studies were conducted. An electronic search of PubMed, Science Direct Scopus, Google Scholar, and Excerpta Medica Database (EMBASE) from June 2020 until June 2022. The long-term health consequences of COVID-19 remain largely unclear. This review highlights the importance of awareness of the potentially increased incidence of venous thromboembolism in post-COVID-19 patients, even those with mild or asymptomatic disease. Further research is required to establish appropriate clinical management guidelines for the prevention of thromboembolic complications in the post-COVID-19 period.", "doi": "10.1007/s42399-022-01273-3", "pmid": "35999860", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "1273"}, {"db": "pmc", "key": "PMC9389494"}], "notes": [], "created": "2022-08-26T04:44:27.340Z", "modified": "2022-08-26T04:44:27.396Z"}, {"entity": "publication", "iuid": "3ca706b10da844938e6670e29373f1c8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ca706b10da844938e6670e29373f1c8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ca706b10da844938e6670e29373f1c8"}}, "title": "Global Prevalence and Potential Influencing Factors of COVID-19 Vaccination Hesitancy: A Meta-Analysis.", "authors": [{"family": "Fajar", "given": "Jonny Karunia", "initials": "JK", "orcid": "0000-0002-0309-5813", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5fb04d101ce4d20a4cb8692bbd67659.json"}}, {"family": "Sallam", "given": "Malik", "initials": "M", "orcid": "0000-0002-0165-9670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb490d3ed32f4b76b8a39bd0320bd748.json"}}, {"family": "Soegiarto", "given": "Gatot", "initials": "G", "orcid": "0000-0002-9197-3873", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ead7821cabe648c6a2c0ec9596015f55.json"}}, {"family": "Sugiri", "given": "Yani Jane", "initials": "YJ"}, {"family": "Anshory", "given": "Muhammad", "initials": "M"}, {"family": "Wulandari", "given": "Laksmi", "initials": "L"}, {"family": "Kosasih", "given": "Stephanie Astrid Puspitasari", "initials": "SAP"}, {"family": "Ilmawan", "given": "Muhammad", "initials": "M"}, {"family": "Kusnaeni", "given": "Kusnaeni", "initials": "K"}, {"family": "Fikri", "given": "Muhammad", "initials": "M"}, {"family": "Putri", "given": "Frilianty", "initials": "F"}, {"family": "Hamdi", "given": "Baitul", "initials": "B"}, {"family": "Pranatasari", "given": "Izza Dinalhaque", "initials": "ID"}, {"family": "Aina", "given": "Lily", "initials": "L", "orcid": "0000-0002-3083-9507", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9fe14a514c9c4768a81272f1dd18e10d.json"}}, {"family": "Maghfiroh", "given": "Lailatul", "initials": "L", "orcid": "0000-0002-6923-3887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9869ffbdd0924f06aef5a9f343c342a6.json"}}, {"family": "Ikhriandanti", "given": "Fernanda Septi", "initials": "FS"}, {"family": "Endiaverni", "given": "Wa Ode", "initials": "WO"}, {"family": "Nugraha", "given": "Krisna Wahyu", "initials": "KW", "orcid": "0000-0001-9188-0346", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8909f02dd3c24e258843c32ea5e903d4.json"}}, {"family": "Wiranudirja", "given": "Ory", "initials": "O"}, {"family": "Edinov", "given": "Sally", "initials": "S"}, {"family": "Hamdani", "given": "Ujang", "initials": "U", "orcid": "0000-0001-8867-0030", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ccfb26ce87148e899456efcec7caea9.json"}}, {"family": "Rosyidah", "given": "Lathifatul", "initials": "L"}, {"family": "Lubaba", "given": "Hanny", "initials": "H"}, {"family": "Ariwibowo", "given": "Rinto", "initials": "R"}, {"family": "Andistyani", "given": "Riska", "initials": "R"}, {"family": "Fitriani", "given": "Ria", "initials": "R"}, {"family": "Hasanah", "given": "Miftahul", "initials": "M"}, {"family": "Nafis", "given": "Fardha Ad Durrun", "initials": "FAD"}, {"family": "Tamara", "given": "Fredo", "initials": "F"}, {"family": "Latamu", "given": "Fitri Olga", "initials": "FO"}, {"family": "Kusuma", "given": "Hendrix Indra", "initials": "HI", "orcid": "0000-0003-3555-0136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d3daa17c23742d0ba36d8dad2d7be79.json"}}, {"family": "Rabaan", "given": "Ali A", "initials": "AA", "orcid": "0000-0002-6774-9847", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6f7d6e2db1e34c19ab20d96af6cf384d.json"}}, {"family": "Alhumaid", "given": "Saad", "initials": "S", "orcid": "0000-0003-4552-4513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5b42c928b1a4d75840ad62b355d06f7.json"}}, {"family": "Mutair", "given": "Abbas Al", "initials": "AA"}, {"family": "Garout", "given": "Mohammed", "initials": "M"}, {"family": "Halwani", "given": "Muhammad A", "initials": "MA"}, {"family": "Alfaresi", "given": "Mubarak", "initials": "M", "orcid": "0000-0003-2523-835X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9115c5a248448748bc57159a479f0e8.json"}}, {"family": "Al Azmi", "given": "Reyouf", "initials": "R"}, {"family": "Alasiri", "given": "Nada A", "initials": "NA", "orcid": "0000-0003-2549-9904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1068b2b4acd46988f349835bda1eccf.json"}}, {"family": "Alshukairi", "given": "Abeer N", "initials": "AN"}, {"family": "Dhama", "given": "Kuldeep", "initials": "K", "orcid": "0000-0001-7469-4752", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef8824b2d5dc494ca3c21dc5e783e677.json"}}, {"family": "Harapan", "given": "Harapan", "initials": "H", "orcid": "0000-0001-7630-8413", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06f2d40c26be48cd8ba815701674b0f1.json"}}], "type": "journal article", "published": "2022-08-19", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "Countries worldwide have deployed mass COVID-19 vaccination drives, but there are people who are hesitant to receive the vaccine. Studies assessing the factors associated with COVID-19 vaccination hesitancy are inconclusive. This study aimed to assess the global prevalence of COVID-19 vaccination hesitancy and determine the potential factors associated with such hesitancy. We performed an organized search for relevant articles in PubMed, Scopus, and Web of Science. Extraction of the required information was performed for each study. A single-arm meta-analysis was performed to determine the global prevalence of COVID-19 vaccination hesitancy; the potential factors related to vaccine hesitancy were analyzed using a Z-test. A total of 56 articles were included in our analysis. We found that the global prevalence of COVID-19 vaccination hesitancy was 25%. Being a woman, being a 50-year-old or younger, being single, being unemployed, living in a household with five or more individuals, having an educational attainment lower than an undergraduate degree, having a non-healthcare-related job and considering COVID-19 vaccines to be unsafe were associated with a higher risk of vaccination hesitancy. In contrast, living with children at home, maintaining physical distancing norms, having ever tested for COVID-19, and having a history of influenza vaccination in the past few years were associated with a lower risk of hesitancy to COVID-19 vaccination. Our study provides valuable information on COVID-19 vaccination hesitancy, and we recommend special interventions in the sub-populations with increased risk to reduce COVID-19 vaccine hesitancy.", "doi": "10.3390/vaccines10081356", "pmid": "36016242", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "vaccines10081356"}, {"db": "pmc", "key": "PMC9412456"}], "notes": [], "created": "2022-09-12T19:13:23.853Z", "modified": "2022-09-12T19:13:46.052Z"}, {"entity": "publication", "iuid": "38520aadc94b49758014b1674c74bf4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38520aadc94b49758014b1674c74bf4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38520aadc94b49758014b1674c74bf4d"}}, "title": "Complement C3 inhibition in severe COVID-19 using compstatin AMY-101.", "authors": [{"family": "Skendros", "given": "Panagiotis", "initials": "P", "orcid": "0000-0003-0456-7015", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f3964bd31a644fb9edb3ddb8012d6ae.json"}}, {"family": "Germanidis", "given": "Georgios", "initials": "G", "orcid": "0000-0001-7985-3118", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b064677471a4dfca38ef7e09409822e.json"}}, {"family": "Mastellos", "given": "Dimitrios C", "initials": "DC", "orcid": "0000-0002-6634-3271", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a842782e093409fa426e83d3ef99663.json"}}, {"family": "Antoniadou", "given": "Christina", "initials": "C", "orcid": "0000-0001-7391-6851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c51d5f05105f49ea9303e95bd81cc91e.json"}}, {"family": "Gavriilidis", "given": "Efstratios", "initials": "E", "orcid": "0000-0002-1591-9760", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a54d5da4ddd49f9b478dcb93bc9205f.json"}}, {"family": "Kalopitas", "given": "Georgios", "initials": "G", "orcid": "0000-0002-4962-790X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ec02ed547494cd4a5648a76204675d2.json"}}, {"family": "Samakidou", "given": "Anna", "initials": "A"}, {"family": "Liontos", "given": "Angelos", "initials": "A", "orcid": "0000-0002-0361-0846", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70560431d93d43e2a48579c019d7fcad.json"}}, {"family": "Chrysanthopoulou", "given": "Akrivi", "initials": "A"}, {"family": "Ntinopoulou", "given": "Maria", "initials": "M"}, {"family": "Kogias", "given": "Dionysios", "initials": "D", "orcid": "0000-0002-2505-7076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7914e0d4d3d64f18855f716e8f7f2910.json"}}, {"family": "Karanika", "given": "Ioanna", "initials": "I"}, {"family": "Smyrlis", "given": "Andreas", "initials": "A", "orcid": "0000-0002-3964-5944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9948578678704ba99655ee7d8eecda93.json"}}, {"family": "Cepaityte", "given": "Dainora", "initials": "D", "orcid": "0000-0003-2652-4120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f9344cdf81d4d1293b919741dd63a6e.json"}}, {"family": "Fotiadou", "given": "Iliana", "initials": "I", "orcid": "0000-0002-7618-4243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa2fc15ebd174048a197345093f8a2e5.json"}}, {"family": "Zioga", "given": "Nikoleta", "initials": "N", "orcid": "0000-0002-8614-6742", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed19a1127a244e4891d8460adf6f93c4.json"}}, {"family": "Mitroulis", "given": "Ioannis", "initials": "I"}, {"family": "Gatselis", "given": "Nikolaos K", "initials": "NK", "orcid": "0000-0002-3715-8640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48a938526b5c4b14bd32e1f0dd90b6f8.json"}}, {"family": "Papagoras", "given": "Charalampos", "initials": "C", "orcid": "0000-0001-6207-496X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1ed3220f27c4dd4bcd76135200ebb4c.json"}}, {"family": "Metallidis", "given": "Simeon", "initials": "S"}, {"family": "Milionis", "given": "Haralampos", "initials": "H", "orcid": "0000-0003-3958-2266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d08064024f26409a98b57a024329787a.json"}}, {"family": "Dalekos", "given": "George N", "initials": "GN", "orcid": "0000-0001-7075-8464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4c60cecbf7d4316b5a2e64267ec7925.json"}}, {"family": "Willems", "given": "Loek", "initials": "L"}, {"family": "Persson", "given": "Barbro", "initials": "B"}, {"family": "Manivel", "given": "Vivek Anand", "initials": "VA", "orcid": "0000-0002-6746-7372", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c45a913d5fdc4446987103f9519cf28f.json"}}, {"family": "Nilsson", "given": "Bo", "initials": "B"}, {"family": "Connolly", "given": "E Sander", "initials": "ES"}, {"family": "Iacobelli", "given": "Simona", "initials": "S"}, {"family": "Papadopoulos", "given": "Vasileios", "initials": "V", "orcid": "0000-0002-4188-9518", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6576628a0472453499d211ea786bdc89.json"}}, {"family": "Calado", "given": "Rodrigo T", "initials": "RT", "orcid": "0000-0002-7966-6029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9cc3032ec8444cf69e4bd24bbc1a1c79.json"}}, {"family": "Huber-Lang", "given": "Markus", "initials": "M", "orcid": "0000-0003-2359-6516", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d93a6fbd9f6446f58a91c65078b4dec0.json"}}, {"family": "Risitano", "given": "Antonio M", "initials": "AM"}, {"family": "Yancopoulou", "given": "Despina", "initials": "D"}, {"family": "Ritis", "given": "Konstantinos", "initials": "K"}, {"family": "Lambris", "given": "John D", "initials": "JD", "orcid": "0000-0002-9370-5776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3feb5c64951b4305b97bcffa49e6154a.json"}}], "type": "journal article", "published": "2022-08-19", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "8", "issue": "33", "pages": "eabo2341", "issn-l": "2375-2548"}, "abstract": "Complement C3 activation contributes to COVID-19 pathology, and C3 targeting has emerged as a promising therapeutic strategy. We provide interim data from ITHACA, the first randomized trial evaluating a C3 inhibitor, AMY-101, in severe COVID-19 (PaO2/FiO2 \u2264 300 mmHg). Patients received AMY-101 (n = 16) or placebo (n = 15) in addition to standard of care. AMY-101 was safe and well tolerated. Compared to placebo (8 of 15, 53.3%), a higher, albeit nonsignificant, proportion of AMY-101-treated patients (13 of 16, 81.3%) were free of supplemental oxygen at day 14. Three nonresponders and two placebo-treated patients succumbed to disease-related complications. AMY-101 significantly reduced CRP and ferritin and restrained thrombin and NET generation. Complete and sustained C3 inhibition was observed in all responders. Residual C3 activity in the three nonresponders suggested the presence of a convertase-independent C3 activation pathway overriding the drug's inhibitory activity. These findings support the design of larger trials exploring the potential of C3-based inhibition in COVID-19 or other complement-mediated diseases.", "doi": "10.1126/sciadv.abo2341", "pmid": "35977025", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9385148"}], "notes": [], "created": "2022-09-12T18:39:40.359Z", "modified": "2022-09-12T18:39:41.017Z"}, {"entity": "publication", "iuid": "1a68a79d4505455ab7cb857cd82eafca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1a68a79d4505455ab7cb857cd82eafca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1a68a79d4505455ab7cb857cd82eafca"}}, "title": "Acute Kidney Injury in COVID-19 Patients: Pathogenesis, Clinical Characteristics, Therapy, and Mortality.", "authors": [{"family": "Ch\u00e1vez-Valencia", "given": "Venice", "initials": "V"}, {"family": "Orizaga-de-la-Cruz", "given": "Citlalli", "initials": "C"}, {"family": "Lagunas-Rangel", "given": "Francisco Alejandro", "initials": "FA", "orcid": "0000-0001-7730-6452", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/737bd8eaf59a4ae28b71f4270c1f56c3.json"}}], "type": "journal article", "published": "2022-08-19", "journal": {"title": "Diseases", "issn": "2079-9721", "volume": "10", "issue": "3", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) is a disease caused by infection with the SARS-CoV-2 virus and has represented one of the greatest challenges humanity has faced in recent years. The virus can infect a large number of organs, including the lungs and upper respiratory tract, brain, liver, kidneys, and intestines, among many others. Although the greatest damage occurs in the lungs, the kidneys are not exempt, and acute kidney injury (AKI) can occur in patients with COVID-19. Indeed, AKI is one of the most frequent and serious organic complications of COVID-19. The incidence of COVID-19 AKI varies widely, and the exact mechanisms of how the virus damages the kidney are still unknown. For this reason, the purpose of this review was to assess current findings on the pathogenesis, clinical features, therapy, and mortality of COVID-19 AKI.", "doi": "10.3390/diseases10030053", "pmid": "35997358", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "diseases10030053"}], "notes": [], "created": "2022-08-26T04:45:32.548Z", "modified": "2022-08-26T04:45:32.621Z"}, {"entity": "publication", "iuid": "e71abb03bfb741cbb5c70008a6c0cd26", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e71abb03bfb741cbb5c70008a6c0cd26.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e71abb03bfb741cbb5c70008a6c0cd26"}}, "title": "A universal SARS-CoV DNA vaccine inducing highly cross-reactive neutralizing antibodies and T cells.", "authors": [{"family": "Appelberg", "given": "Sofia", "initials": "S", "orcid": "0000-0002-7381-3606", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a3e2ab8513742af91714b79b472734a.json"}}, {"family": "Ahl\u00e9n", "given": "Gustaf", "initials": "G", "orcid": "0000-0002-2681-6433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eda17940966a4e059f1598116f8572bf.json"}}, {"family": "Yan", "given": "Jingyi", "initials": "J", "orcid": "0000-0002-2266-7338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/071873148bdc4d588d050516bc7d44b0.json"}}, {"family": "Nikouyan", "given": "Negin", "initials": "N", "orcid": "0000-0003-3588-2448", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fefca010183442c093b01849a08149c6.json"}}, {"family": "Weber", "given": "Sofie", "initials": "S"}, {"family": "Larsson", "given": "Olivia", "initials": "O"}, {"family": "H\u00f6glund", "given": "Urban", "initials": "U"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Weber", "given": "Friedemann", "initials": "F", "orcid": "0000-0001-9737-337X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cfac6ca689c5467396ede57ba57092da.json"}}, {"family": "Perlhamre", "given": "Emma", "initials": "E"}, {"family": "Apro", "given": "Johanna", "initials": "J"}, {"family": "Gidlund", "given": "Eva-Karin", "initials": "E"}, {"family": "Tuvesson", "given": "Ola", "initials": "O", "orcid": "0000-0003-2232-026X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/99b2a259824c4a7abac326481f01bc28.json"}}, {"family": "Salati", "given": "Simona", "initials": "S", "orcid": "0000-0002-8072-1128", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd374f0c8bc34c028ba321a68aa4b85e.json"}}, {"family": "Cadossi", "given": "Matteo", "initials": "M"}, {"family": "Tegel", "given": "Hanna", "initials": "H", "orcid": "0000-0002-7067-9173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d3fde7ee5de4dab899746becfae364d.json"}}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Frelin", "given": "Lars", "initials": "L", "orcid": "0000-0001-7452-1667", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd26ddedec244820a9a1e19f76cc5cf8.json"}}, {"family": "Mirazimi", "given": "Ali", "initials": "A", "orcid": "0000-0003-2371-6055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0651be47429c4e5880a13b839d04fe1d.json"}}, {"family": "S\u00e4llberg", "given": "Matti", "initials": "M", "orcid": "0000-0002-8858-5132", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ef589af054b4f94a635ce4021d19ed6.json"}}], "type": "journal article", "published": "2022-08-19", "journal": {"title": "EMBO Mol Med", "issn": "1757-4684", "issn-l": "1757-4676", "volume": null, "issue": null, "pages": "e15821"}, "abstract": "New variants in the SARS-CoV-2 pandemic are more contagious (Alpha/Delta), evade neutralizing antibodies (Beta), or both (Omicron). This poses a challenge in vaccine development according to WHO. We designed a more universal SARS-CoV-2 DNA vaccine containing receptor-binding domain loops from the huCoV-19/WH01, the Alpha, and the Beta variants, combined with the membrane and nucleoproteins. The vaccine induced spike antibodies crossreactive between huCoV-19/WH01, Beta, and Delta spike proteins that neutralized huCoV-19/WH01, Beta, Delta, and Omicron virus in vitro. The vaccine primed nucleoprotein-specific T cells, unlike spike-specific T cells, recognized Bat-CoV sequences. The vaccine protected mice carrying the human ACE2 receptor against lethal infection with the SARS-CoV-2 Beta variant. Interestingly, priming of cross-reactive nucleoprotein-specific T cells alone was 60% protective, verifying observations from humans that T cells protect against lethal disease. This SARS-CoV vaccine induces a uniquely broad and functional immunity that adds to currently used vaccines.", "doi": "10.15252/emmm.202215821", "pmid": "35986481", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:46:48.046Z", "modified": "2022-09-12T18:47:48.444Z"}, {"entity": "publication", "iuid": "5cd512c8ebc74a6aab9caeb6f2afed41", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5cd512c8ebc74a6aab9caeb6f2afed41.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5cd512c8ebc74a6aab9caeb6f2afed41"}}, "title": "Trends in upper respiratory tract infections and antibiotic prescriptions during the COVID-19 pandemic - a national observational study.", "authors": [{"family": "Gisselsson-Solen", "given": "Marie", "initials": "M", "orcid": "0000-0003-2802-2343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef722726120a4d26ad687988eb841f80.json"}}, {"family": "Hermansson", "given": "Ann", "initials": "A"}], "type": "editorial", "published": "2022-08-18", "journal": {"title": "Acta Otolaryngol", "issn": "1651-2251", "pages": "1-4", "issn-l": "0001-6489"}, "abstract": null, "doi": "10.1080/00016489.2022.2109727", "pmid": "35980331", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:43:07.012Z", "modified": "2022-09-12T18:43:07.066Z"}, {"entity": "publication", "iuid": "76b43f698f12496a8052cbbfcdc0ddfe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76b43f698f12496a8052cbbfcdc0ddfe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76b43f698f12496a8052cbbfcdc0ddfe"}}, "title": "Selective Serotonin Reuptake Inhibitors may Influence COVID-19 Prognosis through Antioxidant and Cytoprotective Pathways Mediated by Sigma 1 Receptor Agonism.", "authors": [{"family": "Papadopoulos", "given": "Konstantinos I", "initials": "KI", "orcid": "0000-0003-0041-7853", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/57c63fdf7036465686e79794a5107544.json"}}, {"family": "Papadopoulou", "given": "Alexandra", "initials": "A", "orcid": "0000-0002-7488-8271", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9000ff7673bc4d35bde729ce8829ab5d.json"}}, {"family": "Aw", "given": "Tar-Choon", "initials": "TC", "orcid": "0000-0002-7814-8836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f95d6a8535d41fbb7b5cf40fb091205.json"}}], "type": "journal article", "published": "2022-08-18", "journal": {"title": "Pharmacopsychiatry", "issn": "1439-0795", "issn-l": null}, "abstract": null, "doi": "10.1055/a-1909-2198", "pmid": "35981550", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:45:06.412Z", "modified": "2022-09-12T18:45:22.624Z"}, {"entity": "publication", "iuid": "16a3ca6332634a2791bbb8a73799d0af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16a3ca6332634a2791bbb8a73799d0af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16a3ca6332634a2791bbb8a73799d0af"}}, "title": "An interrupted time series analysis of gambling behavior based on gambling operator revenue-based taxation during the COVID-19 pandemic in Sweden.", "authors": [{"family": "Andersson", "given": "M J", "initials": "MJ"}, {"family": "Balem", "given": "M", "initials": "M"}, {"family": "H\u00e5kansson", "given": "A", "initials": "A"}], "type": "journal article", "published": "2022-08-18", "journal": {"title": "Public Health", "issn": "1476-5616", "volume": "211", "pages": "14-20", "issn-l": null}, "abstract": "The impact of COVID-19 on gambling behavior and the gambling industry itself has been widely speculated. Prior studies have shown how boredom, social isolation, poor mental health, and financial hardships, all of which have been associated with COVID-19, can aggravate problem gambling behaviors in patients with gambling disorders while also luring newcomers. Few studies have used methods other than self-report to assess longitudinal behavioral changes in gambling behavior before versus during the pandemic.\n\nThe present study addresses this gap by using an interrupted time series approach on data obtained from the Swedish Gambling Authority measuring taxation on gambling vendors' revenue between January 2019 and November 2021.\n\nMarch, June, and October 2020 were chosen as interruption points as they correspond to the pandemic's commencement, the return of elite sports, and the second wave of cases in Sweden, respectively. We hypothesized that the pandemic would be associated with both temporary changes for select gambling types and long-term increases in online gambling.\n\nResults revealed the pandemic's onset was associated with transient effects at each point of interruption, as well as long-term upward trends in total gambling and commercial online gambling, excluding horse betting and the state-owned operator for online casinos and betting.\n\nThe present study's findings, although consistent with the theory that gambling activity could increase during the pandemic, contradict previous studies that found no changes or a decrease from pre-COVID-19 levels. Findings indicate that the pandemic and Sweden's reaction to it were associated with increased use of some gambling products.", "doi": "10.1016/j.puhe.2022.07.003", "pmid": "35988505", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0033-3506(22)00198-6"}], "notes": [], "created": "2022-09-12T18:49:20.251Z", "modified": "2022-09-12T18:49:20.257Z"}, {"entity": "publication", "iuid": "6b199a2fa90e431687b033fc4dc3f90f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b199a2fa90e431687b033fc4dc3f90f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b199a2fa90e431687b033fc4dc3f90f"}}, "title": "Patient lead users experience of the COVID-19 pandemic: a qualitative interview study.", "authors": [{"family": "Jansson", "given": "Hanna", "initials": "H", "orcid": "0000-0002-1615-0463", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88337ae732344b7fb3ebc5a04ef9894b.json"}}, {"family": "Stenfors", "given": "Terese", "initials": "T", "orcid": "0000-0002-0854-8631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/785692870b584906b79702cbfdac8866.json"}}, {"family": "Riggare", "given": "Sara", "initials": "S", "orcid": "0000-0002-2256-7310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ffa9b36c39043578cfa21a881699ea7.json"}}, {"family": "Hasson", "given": "Henna", "initials": "H", "orcid": "0000-0002-3827-6841", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1c2ba4af37b4c678656ea948b76fa93.json"}}, {"family": "Reinius", "given": "Maria", "initials": "M", "orcid": "0000-0003-0864-8701", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8dc0b4c1305b49349adfb8f4da310856.json"}}], "type": "journal article", "published": "2022-08-17", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "8", "pages": "e059003", "issn-l": "2044-6055"}, "abstract": "Patient lead users can be defined as patients or relatives who use their knowledge and experience to improve their own or a relative's care situation and/or the healthcare system, and who are active beyond what is usually expected. The objective of this study is to explore patient lead users' experiences and engagement during the early COVID-19 pandemic.\n\nQualitative in-depth interviews with a cross-sectional time horizon.\n\nThe early COVID-19 pandemic in Sweden, from 1 June through 14 September, 2020.\n\nA total of 10 patient lead users were recruited from the Swedish patient lead users (spetspatient) network. All participants were living with different long-term conditions and matched the definition of being patient lead users.\n\nWe found that during the early pandemic, patient lead users experienced that they no longer knew how to best manage their own health and care situations. On an individual level, they described an initial lack of knowledge, new routines, including a change in their health and an experience of people without a disease being in the same situation as them, for a while. On a systemic level, they described a fear of imminent unmet-care backlogs and decreased opportunities for sharing patient perspectives in care organisation, but also described increased networking.\n\nPatient lead users can be seen as an emerging community of practice, and as such could be a valuable resource as a complementary communication channel for an improved health system. The health systems were not able to fully acknowledge and engage with the resource of patient lead users during the pandemic.", "doi": "10.1136/bmjopen-2021-059003", "pmid": "35977768", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-059003"}, {"db": "pmc", "key": "PMC9388713"}], "notes": [], "created": "2022-09-12T18:40:01.486Z", "modified": "2022-09-12T18:40:01.671Z"}, {"entity": "publication", "iuid": "6d6ea640ecfb4b2e89afbd38ac585f69", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6d6ea640ecfb4b2e89afbd38ac585f69.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6d6ea640ecfb4b2e89afbd38ac585f69"}}, "title": "How much are we worth? Experiences of nursing assistants in Swedish nursing homes during the first wave of COVID-19.", "authors": [{"family": "Bergqvist", "given": "Monica", "initials": "M", "orcid": "0000-0002-3061-4885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/024ed86bac7d4d64a4073057c79f05e1.json"}}, {"family": "Bastholm-Rahmner", "given": "Pia", "initials": "P"}, {"family": "Gustafsson", "given": "Lars L", "initials": "LL"}, {"family": "Holmgren", "given": "Katarina", "initials": "K"}, {"family": "Veg", "given": "Anik\u00f3", "initials": "A"}, {"family": "Wachtler", "given": "Caroline", "initials": "C"}, {"family": "Schmidt-Mende", "given": "Katharina", "initials": "K"}], "type": "journal article", "published": "2022-08-17", "journal": {"title": "Int J Older People Nurs", "issn": "1748-3743", "pages": "e12498", "issn-l": null}, "abstract": "NHs have been severely exposed during the COVID-19 pandemic. Little is known about how staff who provide practical daily care of older residents experienced work during the pandemic. The aim of this study was to understand how nursing assistants (NAs) experienced their work at nursing homes (NHs) for older people during the first wave of the COVID-19 pandemic.\n\nWe conducted a qualitative study of focus group discussions with in total 20 participants from four NHs in Stockholm, Sweden. Discussions were held in November 2020. Transcripts were analyzed using inductive thematic analysis.\n\nWe identified three major themes: 1) We felt abandoned, scared and disrespected, 2) We made sure we made it through, and 3) We can do good work with appropriate resources. NAs felt disregarded as they were often left alone without adequate support from managers, registered nurses and the municipalities. NAs felt distressed and guilty and developed their own strategies to cope and manage their work.\n\nDuring the first wave of the COVID-19 pandemic NAs felt abandoned and burdened due to lack of leadership. Organizational improvements are required to protect the wellbeing of NAs and to ensure sustainability of patient safety. NAs are crucial in the care for vulnerable older people and their experiences should constitute a keystone for development of future policy and practice in NHs.", "doi": "10.1111/opn.12498", "pmid": "35978489", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:41:01.840Z", "modified": "2022-09-12T18:41:01.886Z"}, {"entity": "publication", "iuid": "cc3a334d201a409581528d405736ac48", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc3a334d201a409581528d405736ac48.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc3a334d201a409581528d405736ac48"}}, "title": "Efficacy of Kan Jang\u00ae in Patients with Mild COVID-19: Interim Analysis of a Randomized, Quadruple-Blind, Placebo-Controlled Trial.", "authors": [{"family": "Ratiani", "given": "Levan", "initials": "L"}, {"family": "Pachkoria", "given": "Elene", "initials": "E"}, {"family": "Mamageishvili", "given": "Nato", "initials": "N"}, {"family": "Shengelia", "given": "Ramaz", "initials": "R"}, {"family": "Hovhannisyan", "given": "Areg", "initials": "A"}, {"family": "Panossian", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8467-4525", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86a40ce1842b4c289c7f09c955ad4325.json"}}], "type": "journal article", "published": "2022-08-17", "journal": {"title": "Pharmaceuticals (Basel)", "issn": "1424-8247", "volume": "15", "issue": "8", "issn-l": null}, "abstract": "Kan Jang\u00ae, the fixed combination of Andrographis paniculata (Burm. F.) Wall. ex. Nees and Eleutherococcus senticosus (Rupr. & Maxim.) Maxim extracts, is a herbal medicinal product for relieving symptoms of upper respiratory tract infections. This study aimed to assess the efficacy of Kan Jang\u00ae/Nergecov\u00ae on duration and the relief of inflammatory symptoms in adults with mild COVID-19. 86 patients with laboratory-confirmed COVID-19 and mild symptoms for one to three days received supportive treatment (paracetamol) and six Kan Jang\u00ae (daily dose of andrographolides-90 mg) or placebo capsules a day for 14 consecutive days in this randomized, quadruple-blinded, placebo-controlled, two-parallel-group study. The primary efficacy outcomes were the decrease in the acute-phase duration and the severity of symptoms score (sore throat, runny nose, cough, headache, fatigue, loss of smell, taste, pain in muscles), an increase in cognitive functions, physical performance, quality of life, and decrease in IL-6, c-reactive protein, and D-dimer in blood. Kan Jang\u00ae/Nergecov\u00ae was effective in reducing the risk of progression to severe COVID-19, decreasing the disease progression rate by almost 2.5-fold compared to placebo. Absolute risk reduction by Kan Jang treatment is 14%, the relative risk reduction is 243.9%, and the number Needed to Treat is 7.14. Kan Jang\u00ae/Nergecov\u00ae reduces the duration of disease, virus clearance, and days of hospitalization and accelerates recovery of patients, relief of sore throat, muscle pain, runny nose, and normalization of body temperature. Kan Jang\u00ae/Nergecov\u00ae significantly relieves the severity of inflammatory symptoms such as sore throat, runny nose, and muscle pain, decreases pro-inflammatory cytokine IL-6 level in the blood, and increases patients' physical performance (workout) compared to placebo. In this study, for the first time we demonstrate that Kan Jang\u00ae/Nergecov\u00ae is effective in treating mild COVID-19.", "doi": "10.3390/ph15081013", "pmid": "36015163", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ph15081013"}, {"db": "pmc", "key": "PMC9415141"}], "notes": [], "created": "2022-09-12T19:09:35.337Z", "modified": "2022-09-12T19:10:23.139Z"}, {"entity": "publication", "iuid": "f2efe20b1f2d4472831be246d161f6c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f2efe20b1f2d4472831be246d161f6c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f2efe20b1f2d4472831be246d161f6c9"}}, "title": "Impact of ultra-processed food intake on the risk of COVID-19: a prospective cohort study.", "authors": [{"family": "Zhou", "given": "Lihui", "initials": "L"}, {"family": "Li", "given": "Huiping", "initials": "H"}, {"family": "Zhang", "given": "Shunming", "initials": "S"}, {"family": "Yang", "given": "Hongxi", "initials": "H"}, {"family": "Ma", "given": "Yue", "initials": "Y"}, {"family": "Wang", "given": "Yaogang", "initials": "Y"}], "type": "journal article", "published": "2022-08-16", "journal": {"title": "Eur J Nutr", "issn": "1436-6215", "issn-l": null}, "abstract": "Nutrition plays a key role in supporting the human immune system and reducing the risk of infections. However, there is limited evidence exploring the relationship between diet and the risk of COVID-19. This study aimed to assess the associations between consumption of ultra-processed foods (UPF) and COVID-19 risk.\n\nIn total, 41,012 participants from the UK Biobank study with at least 2 of up to 5 times 24-h dietary assessments were included in this study. Dietary intakes were collected using an online 24-h dietary recall questionnaire and food items were categorized according to their degree of processing by the NOVA classification. COVID-19 infection was defined as individuals tested COVID-19 positive or dead of COVID-19. Association between average UPF consumption (% daily gram intake) and COVID-19 infection was assessed by multivariable logistic regression adjusted for potential confounders.\n\nCompared to participants in the lowest quartile of UPF proportion (% daily gram intake) in the diet, participants in the 2nd, 3rd, and highest quartiles were associated with a higher risk of COVID-19 with the odds ratio (OR) value of 1.03 (95% CI: 0.94-1.13), 1.24 (95% CI: 1.13-1.36), and 1.22 (95% CI: 1.12-1.34), respectively (P for trend < 0.001), after adjusting for potential confounders. The results were robust in a series of sensitivity analyses. No interaction effect was identified between the UPF proportions and age groups, education level, body mass index, and comorbidity status. BMI mediated 13.2% of this association.\n\nHigher consumption of UPF was associated with an increased risk of COVID-19 infection. Further studies are needed to better understand the underlying mechanisms in such association.", "doi": "10.1007/s00394-022-02982-0", "pmid": "35972529", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00394-022-02982-0"}], "notes": [], "created": "2022-08-19T05:25:41.640Z", "modified": "2022-08-19T05:25:41.676Z"}, {"entity": "publication", "iuid": "9564edc63b0b4c53aca2c2efaa8d8244", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9564edc63b0b4c53aca2c2efaa8d8244.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9564edc63b0b4c53aca2c2efaa8d8244"}}, "title": "Fundamental social motives measured across forty-two cultures in two waves.", "authors": [{"family": "Pick", "given": "Cari M", "initials": "CM", "orcid": "0000-0002-3703-156X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78a16cde2616434d8b45e193bb7a4d2b.json"}}, {"family": "Ko", "given": "Ahra", "initials": "A"}, {"family": "Kenrick", "given": "Douglas T", "initials": "DT"}, {"family": "Wiezel", "given": "Adi", "initials": "A"}, {"family": "Wormley", "given": "Alexandra S", "initials": "AS", "orcid": "0000-0001-9892-6087", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd7c1f83116043b9b0aafb8eba3ce0f2.json"}}, {"family": "Awad", "given": "Edmond", "initials": "E", "orcid": "0000-0001-7272-7186", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3399850d2c804849830ada06b5a2c264.json"}}, {"family": "Al-Shawaf", "given": "Laith", "initials": "L", "orcid": "0000-0002-8600-0591", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5da08e43eb45476cb8f58e402a30a220.json"}}, {"family": "Barry", "given": "Oumar", "initials": "O"}, {"family": "Bereby-Meyer", "given": "Yoella", "initials": "Y"}, {"family": "Boonyasiriwat", "given": "Watcharaporn", "initials": "W"}, {"family": "Brandst\u00e4tter", "given": "Eduard", "initials": "E"}, {"family": "Ceylan-Batur", "given": "Suzan", "initials": "S"}, {"family": "Choy", "given": "Bryan K C", "initials": "BKC"}, {"family": "Crispim", "given": "Ana Carla", "initials": "AC", "orcid": "0000-0003-3434-5667", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92a6c50510514095856558adcbcea5f0.json"}}, {"family": "Cruz", "given": "Julio Eduardo", "initials": "JE"}, {"family": "David", "given": "Daniel", "initials": "D"}, {"family": "David", "given": "Oana A", "initials": "OA"}, {"family": "Defelipe", "given": "Renata Pereira", "initials": "RP"}, {"family": "Elmas", "given": "Pinar", "initials": "P"}, {"family": "Espinosa", "given": "Agust\u00edn", "initials": "A"}, {"family": "Fernandez", "given": "Ana Maria", "initials": "AM", "orcid": "0000-0003-4132-5891", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62a5afa4f51d4eedb88d47f14e79369a.json"}}, {"family": "Fetvadjiev", "given": "Velichko H", "initials": "VH", "orcid": "0000-0002-5475-5121", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d19fbc56230947648979491718129881.json"}}, {"family": "Fetvadjieva", "given": "Stefka", "initials": "S"}, {"family": "Fischer", "given": "Ronald", "initials": "R"}, {"family": "Galdi", "given": "Silvia", "initials": "S", "orcid": "0000-0002-1343-9245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1f426be397e4444ab9e2a9985db301b.json"}}, {"family": "Galindo-Caballero", "given": "Oscar Javier", "initials": "OJ", "orcid": "0000-0003-4603-6415", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a790435cd0b146b19f284104cd63b6fc.json"}}, {"family": "Golovina", "given": "Elena V", "initials": "EV", "orcid": "0000-0003-3053-6706", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5659b410753b4f908cb6b537adbb7678.json"}}, {"family": "Golovina", "given": "Galina M", "initials": "GM", "orcid": "0000-0002-2747-1422", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3331b31e6ff4acdbfc22b032356ba9f.json"}}, {"family": "Gomez-Jacinto", "given": "Luis", "initials": "L"}, {"family": "Graf", "given": "Sylvie", "initials": "S"}, {"family": "Grossmann", "given": "Igor", "initials": "I", "orcid": "0000-0003-2681-3600", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88e68a874f26479e84ddeca2112a1915.json"}}, {"family": "Gul", "given": "Pelin", "initials": "P"}, {"family": "Halama", "given": "Peter", "initials": "P"}, {"family": "Hamamura", "given": "Takeshi", "initials": "T"}, {"family": "Han", "given": "Shihui", "initials": "S"}, {"family": "Hansson", "given": "Lina S", "initials": "LS"}, {"family": "Hitokoto", "given": "Hidefumi", "initials": "H"}, {"family": "H\u0159eb\u00ed\u010dkov\u00e1", "given": "Martina", "initials": "M", "orcid": "0000-0002-8700-1326", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/224b1347d51b471f85e0f77e98166139.json"}}, {"family": "Ilic", "given": "Darinka", "initials": "D"}, {"family": "Johnson", "given": "Jennifer Lee", "initials": "JL"}, {"family": "Kara-Yakoubian", "given": "Mane", "initials": "M"}, {"family": "Karl", "given": "Johannes A", "initials": "JA"}, {"family": "Kim", "given": "Jinseok P", "initials": "JP"}, {"family": "Koh\u00fat", "given": "Michal", "initials": "M"}, {"family": "Lasselin", "given": "Julie", "initials": "J"}, {"family": "Lee", "given": "Hwaryung", "initials": "H"}, {"family": "Li", "given": "Norman P", "initials": "NP"}, {"family": "Mafra", "given": "Anthonieta Looman", "initials": "AL"}, {"family": "Malanchuk", "given": "Oksana", "initials": "O"}, {"family": "Moran", "given": "Simone", "initials": "S", "orcid": "0000-0002-2261-050X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba0b4c98e1bf4aedb45d4cb5e5c93a5c.json"}}, {"family": "Murata", "given": "Asuka", "initials": "A"}, {"family": "Na", "given": "Jinkyung", "initials": "J"}, {"family": "Ndiaye", "given": "Serigne Abdou Lahat", "initials": "SAL"}, {"family": "O", "given": "Jiaqing", "initials": "J"}, {"family": "Onyishi", "given": "Ike E", "initials": "IE"}, {"family": "Pasay-An", "given": "Eddieson", "initials": "E"}, {"family": "Rizwan", "given": "Muhammed", "initials": "M"}, {"family": "Roth", "given": "Eric", "initials": "E"}, {"family": "Salgado", "given": "Sergio", "initials": "S", "orcid": "0000-0003-1398-3416", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b6bf70dfbf74c1a8c23cdfdc6258bd1.json"}}, {"family": "Samoylenko", "given": "Elena S", "initials": "ES", "orcid": "0000-0001-7980-3903", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b10af86df3744498bfe140dcfb5a91c.json"}}, {"family": "Savchenko", "given": "Tatyana N", "initials": "TN"}, {"family": "Sette", "given": "Catarina", "initials": "C"}, {"family": "Sevincer", "given": "A Timur", "initials": "AT"}, {"family": "Skoog", "given": "Eric", "initials": "E"}, {"family": "Stanciu", "given": "Adrian", "initials": "A"}, {"family": "Suh", "given": "Eunkook M", "initials": "EM"}, {"family": "Sznycer", "given": "Daniel", "initials": "D"}, {"family": "Talhelm", "given": "Thomas", "initials": "T", "orcid": "0000-0002-0954-5758", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65d0fc062c0042479749c70085549e24.json"}}, {"family": "Ugwu", "given": "Fabian O", "initials": "FO"}, {"family": "Uskul", "given": "Ayse K", "initials": "AK"}, {"family": "Uz", "given": "Irem", "initials": "I"}, {"family": "Valentova", "given": "Jaroslava Varella", "initials": "JV"}, {"family": "Varella", "given": "Marco Antonio Correa", "initials": "MAC"}, {"family": "Wei", "given": "Liuqing", "initials": "L"}, {"family": "Zambrano", "given": "Danilo", "initials": "D"}, {"family": "Varnum", "given": "Michael E W", "initials": "MEW", "orcid": "0000-0002-2088-6086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05c99a538ea14289988c9a52f9673a37.json"}}], "type": "journal article", "published": "2022-08-16", "journal": {"title": "Sci Data", "issn": "2052-4463", "volume": "9", "issue": "1", "pages": "499", "issn-l": null}, "abstract": "H\ufeffow does psychology vary across human societies? The fundamental social motives framework adopts an evolutionary approach to capture the broad range of human social goals within a taxonomy of ancestrally recurring threats and opportunities. These motives-self-protection, disease avoidance, affiliation, status, mate acquisition, mate retention, and kin care-are high in fitness relevance and everyday salience, yet understudied cross-culturally. Here, we gathered data on these motives in 42 countries (N = 15,915) in two cross-sectional waves, including 19 countries (N = 10,907) for which data were gathered in both waves. Wave 1 was collected from mid-2016 through late 2019 (32 countries, N = 8,998; 3,302 male, 5,585 female; Mage = 24.43, SD = 7.91). Wave 2 was collected from April through November 2020, during the COVID-19 pandemic (29 countries, N = 6,917; 2,249 male, 4,218 female; Mage = 28.59, SD = 11.31). These data can be used to assess differences and similarities in people's fundamental social motives both across and within cultures, at different time points, and in relation to other commonly studied cultural indicators and outcomes.", "doi": "10.1038/s41597-022-01579-w", "pmid": "35974021", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41597-022-01579-w"}], "notes": [], "created": "2022-08-17T10:31:13.999Z", "modified": "2022-08-19T05:24:57.474Z"}, {"entity": "publication", "iuid": "b2c703b7a7ea4ae5a081a00bc6cd263e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b2c703b7a7ea4ae5a081a00bc6cd263e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b2c703b7a7ea4ae5a081a00bc6cd263e"}}, "title": "Symptoms of anxiety and depression during the COVID-19 pandemic in six European countries and Australia - Differences by prior mental disorders and migration status.", "authors": [{"family": "G\u00e9mes", "given": "Katalin", "initials": "K", "orcid": "0000-0003-3335-7850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe866acb6ee744e7a413be9348fd3463.json"}}, {"family": "Bergstr\u00f6m", "given": "Jakob", "initials": "J"}, {"family": "Papola", "given": "Davide", "initials": "D"}, {"family": "Barbui", "given": "Corrado", "initials": "C"}, {"family": "Lam", "given": "Agnes Iok Fong", "initials": "AIF"}, {"family": "Hall", "given": "Brian J", "initials": "BJ"}, {"family": "Seedat", "given": "Soraya", "initials": "S"}, {"family": "Morina", "given": "Naser", "initials": "N"}, {"family": "Quero", "given": "Soledad", "initials": "S"}, {"family": "Campos", "given": "Daniel", "initials": "D"}, {"family": "Pinucci", "given": "Irene", "initials": "I"}, {"family": "Tarsitani", "given": "Lorenzo", "initials": "L"}, {"family": "Deguen", "given": "S\u00e9verine", "initials": "S"}, {"family": "van der Waerden", "given": "Judith", "initials": "J"}, {"family": "Patan\u00e8", "given": "Martina", "initials": "M"}, {"family": "Sijbrandij", "given": "Marit", "initials": "M"}, {"family": "Acart\u00fcrk", "given": "Ceren", "initials": "C"}, {"family": "Burchert", "given": "Sebastian", "initials": "S"}, {"family": "Bryant", "given": "Richard A", "initials": "RA"}, {"family": "Mittendorfer-Rutz", "given": "Ellenor", "initials": "E"}], "type": "journal article", "published": "2022-08-15", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "volume": "311", "pages": "214-223", "issn-l": null}, "abstract": "Little is known about changes of mental health during the COVID-19 pandemic in potentially disadvantaged groups. We investigated changes in anxiety and depression symptoms during the first year of the pandemic in six European countries and Australia by prior mental disorders and migration status.\n\nOverall, 4674 adults answered a web-based survey in May-June 2020 and were followed by three repeated surveys up to February 2021. Information on psychosocial, financial and demographic, living conditions, prior mental disorders, depression and anxiety symptoms during the pandemic and migration status was collected. Weighted general estimation equations modelling was used to investigate the association between prior mental disorders, migration status, and symptoms over time.\n\nMost participants were <40 years old (48%), women (78%) and highly educated (62%). The baseline prevalence of depressive and anxiety symptoms ranged between 19%-45% and 13%-35%, respectively. In most countries, prevalence rates remained unchanged throughout the pandemic and were higher among people with prior mental disorders than without even after adjustment for several factors. We observed interactions between previous mental disorders and symptoms of anxiety or depression over time in two countries. No difference by migration status was noted.\n\nConvenience sampling limits generalizability. Self-assessed symptoms of depression and anxiety might involve some misclassification.\n\nDepression and anxiety symptoms were worse among individuals with prior mental disorders than without, but there was no clear trend of worsening mental health in the observed groups during the observed period.", "doi": "10.1016/j.jad.2022.05.082", "pmid": "35598751", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9119165"}, {"db": "pii", "key": "S0165-0327(22)00596-1"}], "notes": [], "created": "2022-06-21T17:58:19.742Z", "modified": "2023-06-19T14:52:50.464Z"}, {"entity": "publication", "iuid": "62280c2192c346a1ab87f0b00ac6c948", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/62280c2192c346a1ab87f0b00ac6c948.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/62280c2192c346a1ab87f0b00ac6c948"}}, "title": "Poor long-term recovery after critical COVID-19 during 12 months longitudinal follow-up.", "authors": [{"family": "Larsson", "given": "Ing-Marie", "initials": "IM"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Rubertsson", "given": "Sten", "initials": "S"}, {"family": "Wallin", "given": "Ewa", "initials": "E"}], "type": "journal article", "published": "2022-08-15", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "pages": "103311", "issn-l": null}, "abstract": "This study aimed to describe the burden of illness and impact on health and working situation among former intensive care patients treated for COVID-19.\n\nA prospective cohort study was performed at one intensive care unit of a university hospital in Sweden during the first wave of COVID-19 in spring 2020. The burden of illness in health status, cognitive, physical, and psychological outcomes, and working situation were assessed at four and 12 months after discharge from intensive care, using nine validated instruments.\n\nForty-six participants treated for COVID-19 participated in both follow-ups and were included in this study. General fatigue was reported by 37 of 46 participants (82%) at both follow-ups (p = 1.000). For overall health status 28 (61%) participants at the first follow-up and 26 (57%) (p = 0.414) at the second reported lower values than the general population. Cognitive impairment was seen in 22 (52%) participants at four months and in 13 (31%) at 12 months (p = 0.029). The proportion of participants on sick-leave decreased between the first and second follow-up (24% vs 13%, p = 0.025), but the proportion of participants working full-time was almost the same at both follow-ups (35% vs 37%, p = 0.317).\n\nThe burden of illness of patients treated in intensive care due to COVID-19 included cognitive, physical, and psychological impacts. Cognitive functions were improved after 12 months, but no clear improvements could be distinguished in the physical or psychological outcome. Higher burden of illness was associated with inability to return to work.", "doi": "10.1016/j.iccn.2022.103311", "pmid": "36028412", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(22)00114-8"}, {"db": "pmc", "key": "PMC9376301"}], "notes": [], "created": "2022-09-12T19:16:13.070Z", "modified": "2022-09-12T19:16:13.086Z"}, {"entity": "publication", "iuid": "11fd59eaf9764e9a8e6755f71a276a98", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/11fd59eaf9764e9a8e6755f71a276a98.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/11fd59eaf9764e9a8e6755f71a276a98"}}, "title": "Estimates of the Global Burden of COVID-19 and the Value of Broad and Equitable Access to COVID-19 Vaccines.", "authors": [{"family": "Bell", "given": "Eleanor", "initials": "E"}, {"family": "Brassel", "given": "Simon", "initials": "S"}, {"family": "Oliver", "given": "Edward", "initials": "E"}, {"family": "Schirrmacher", "given": "Hannah", "initials": "H"}, {"family": "Arnetorp", "given": "Sofie", "initials": "S"}, {"family": "Berg", "given": "Katja", "initials": "K"}, {"family": "Darroch-Thompson", "given": "Duncan", "initials": "D"}, {"family": "Pohja-Hutchison", "given": "Paula", "initials": "P"}, {"family": "Mungall", "given": "Bruce", "initials": "B", "orcid": "0000-0002-6772-1633", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/000d4730d4874855be8d266b84e473d5.json"}}, {"family": "Carroll", "given": "Stuart", "initials": "S"}, {"family": "Postma", "given": "Maarten", "initials": "M"}, {"family": "Steuten", "given": "Lotte", "initials": "L"}], "type": "journal article", "published": "2022-08-15", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "The objectives of this research were to produce a macro-level overview of the global COVID-19 burden and estimate the value of access to COVID-19 vaccines. A targeted literature review collated evidence of the burden. Linear modelling and data analysis estimated the health and economic effects of COVID-19 vaccines delivered in 2021, and whether additional value could have been achieved with broader and more equitable access. By 1 December 2020, there had been an estimated 17 million excess deaths due to COVID-19. Low-income countries allocated more than 30% of their healthcare budgets to COVID-19, compared to 8% in high-income countries. All country income groups experienced gross domestic product (GDP) growth lower than predicted in 2020. If all 92 countries eligible for COVAX Advance Market Committee (AMC), access had reached 40% vaccination coverage in 2021, 120% more excess deaths would have been averted, equivalent to USD 5 billion (109) in savings to healthcare systems. Every USD spent by advanced economies on vaccinations for less advanced economies averted USD 28 of economic losses in advanced economies and USD 29 in less advanced economies. The cost to high-income countries when not all countries are vaccinated far outweighs the cost of manufacturing and distributing vaccines globally.", "doi": "10.3390/vaccines10081320", "pmid": "36016208", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "vaccines10081320"}, {"db": "pmc", "key": "PMC9414589"}], "notes": [], "created": "2022-09-12T19:12:59.235Z", "modified": "2022-09-12T19:12:59.286Z"}, {"entity": "publication", "iuid": "6ec8cb2dc00147058afc7de3e5220305", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ec8cb2dc00147058afc7de3e5220305.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ec8cb2dc00147058afc7de3e5220305"}}, "title": "ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19.", "authors": [{"family": "Pietzner", "given": "Maik", "initials": "M", "orcid": "0000-0003-3437-9963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae2392fc827747cea946168e9ab60117.json"}}, {"family": "Chua", "given": "Robert Lorenz", "initials": "RL"}, {"family": "Wheeler", "given": "Eleanor", "initials": "E", "orcid": "0000-0002-8616-6444", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd3b1a02da1d4d2eb7ac766ba6f8bc3a.json"}}, {"family": "Jechow", "given": "Katharina", "initials": "K"}, {"family": "Willett", "given": "Julian D S", "initials": "JDS"}, {"family": "Radbruch", "given": "Helena", "initials": "H", "orcid": "0000-0001-6941-3397", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2079cbe1c9644d808083075882dfaadf.json"}}, {"family": "Trump", "given": "Saskia", "initials": "S"}, {"family": "Heidecker", "given": "Bettina", "initials": "B"}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ee1510080704cf6a2a6972deb94123f.json"}}, {"family": "Heppner", "given": "Frank L", "initials": "FL", "orcid": "0000-0001-9816-8917", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2b4021b116b445b9a1cd7cf7d82b3ba.json"}}, {"family": "Eils", "given": "Roland", "initials": "R"}, {"family": "Mall", "given": "Marcus A", "initials": "MA", "orcid": "0000-0002-4057-2199", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02b1007277d345789ac961a0d9d0eadc.json"}}, {"family": "Richards", "given": "J Brent", "initials": "JB", "orcid": "0000-0002-3746-9086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8994152547ee4765b1653b834c52a21a.json"}}, {"family": "Sander", "given": "Leif-Erik", "initials": "LE", "orcid": "0000-0002-0476-9947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36c4c59d112a4a2dbdc313dcd69c9702.json"}}, {"family": "Lehmann", "given": "Irina", "initials": "I"}, {"family": "Lukassen", "given": "S\u00f6ren", "initials": "S", "orcid": "0000-0001-7045-6327", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f138415d18c54a29a45151d2503c7166.json"}}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0003-1422-2993", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd19f9bbc2994ab3aef6731904c05dd7.json"}}, {"family": "Conrad", "given": "Christian", "initials": "C", "orcid": "0000-0001-7036-342X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee26a84058fe4316a74e87de6021b51b.json"}}, {"family": "Langenberg", "given": "Claudia", "initials": "C", "orcid": "0000-0002-5017-7344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa75a577048f439f9804254975b25c9d.json"}}], "type": "journal article", "published": "2022-08-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "4484", "issn-l": "2041-1723"}, "abstract": "Despite two years of intense global research activity, host genetic factors that predispose to a poorer prognosis of COVID-19 infection remain poorly understood. Here, we prioritise eight robust (e.g., ELF5) or suggestive but unreported (e.g., RAB2A) candidate protein mediators of COVID-19 outcomes by integrating results from the COVID-19 Host Genetics Initiative with population-based plasma proteomics using statistical colocalisation. The transcription factor ELF5 (ELF5) shows robust and directionally consistent associations across different outcome definitions, including a >4-fold higher risk (odds ratio: 4.88; 95%-CI: 2.47-9.63; p-value < 5.0 \u00d7 10-6) for severe COVID-19 per 1 s.d. higher genetically predicted plasma ELF5. We show that ELF5 is specifically expressed in epithelial cells of the respiratory system, such as secretory and alveolar type 2 cells, using single-cell RNA sequencing and immunohistochemistry. These cells are also likely targets of SARS-CoV-2 by colocalisation with key host factors, including ACE2 and TMPRSS2. In summary, large-scale human genetic studies together with gene expression at single-cell resolution highlight ELF5 as a risk gene for severe COVID-19, supporting a role of epithelial cells of the respiratory system in the adverse host response to SARS-CoV-2.", "doi": "10.1038/s41467-022-31999-6", "pmid": "35970849", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-022-31999-6"}], "notes": [], "created": "2022-08-16T15:36:49.489Z", "modified": "2022-08-16T15:36:49.829Z"}, {"entity": "publication", "iuid": "6f8eeeda1af643599fc32e33819ababb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f8eeeda1af643599fc32e33819ababb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f8eeeda1af643599fc32e33819ababb"}}, "title": "COVID-19 and Risk of Oxygen-Dependent Chronic Respiratory Failure: A National Cohort Study.", "authors": [{"family": "Sundh", "given": "Josefin", "initials": "J", "orcid": "0000-0003-1926-8464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0994c494df3b4955bedb00606add70d6.json"}}, {"family": "Ekstr\u00f6m", "given": "Magnus", "initials": "M", "orcid": "0000-0002-7227-5113", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ba0a61aa5e54bd6be6f29d7b5b02033.json"}}, {"family": "Palm", "given": "Andreas", "initials": "A", "orcid": "0000-0002-0590-0417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7f49fdf5aee42af9988590a914afb4f.json"}}, {"family": "Ljunggren", "given": "Mirjam", "initials": "M", "orcid": "0000-0002-8486-6746", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ff050327b5f4bc6834723a8244989e9.json"}}, {"family": "Emilsson", "given": "\u00d6ssur Ingi", "initials": "\u00d6I", "orcid": "0000-0002-7199-8491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/269f70619f6a4880b4f45047f43ab7e1.json"}}, {"family": "Grote", "given": "Ludger", "initials": "L", "orcid": "0000-0002-7405-1682", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8172ded15f0b4332b7ab54d7f131b87a.json"}}, {"family": "Cajander", "given": "Sara", "initials": "S", "orcid": "0000-0003-3921-4244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51683903983f4778bfda99da291f2446.json"}}, {"family": "Li", "given": "Huiqi", "initials": "H", "orcid": "0000-0002-1127-0829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e3bd3ff6b4e4f448f9332081da1dc29.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}], "type": "letter", "published": "2022-08-15", "journal": {"title": "Am J Respir Crit Care Med", "issn": "1535-4970", "issn-l": "1073-449X", "volume": "206", "issue": "4", "pages": "506-509"}, "abstract": null, "doi": "10.1164/rccm.202202-0323LE", "pmid": "35549847", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-01-13T09:57:49.375Z", "modified": "2023-01-13T09:59:02.287Z"}, {"entity": "publication", "iuid": "69915d78ba4142779dd2463e72168f57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69915d78ba4142779dd2463e72168f57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69915d78ba4142779dd2463e72168f57"}}, "title": "COVAD survey 2 long-term outcomes: unmet need and protocol.", "authors": [{"family": "Fazal", "given": "Zoha Zahid", "initials": "ZZ", "orcid": "0000-0003-1576-724X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ca989a85bcfc451285f65a09cc2239a7.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Ravichandran", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-0986-8354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2e6226ae5e7427fbf52e180dd14e28f.json"}}, {"family": "Kardes", "given": "Sinan", "initials": "S", "orcid": "0000-0002-6311-8634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2900c3ca00da476a8914574384a3c9c2.json"}}, {"family": "Kim", "given": "Minchul", "initials": "M", "orcid": "0000-0001-9737-6255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd2952c6167b4733bfbce019a162b310.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Selva-O'Callaghan", "given": "Albert", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0003-2823-9761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef3e202c049b44a2a5e045bac90a393a.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Guti\u00e9rrez", "given": "Carlos-Enrique Toro", "initials": "CT"}, {"family": "Caballero-Uribe", "given": "Carlo Vinicio", "initials": "CV"}, {"family": "Dey", "given": "Dzifa", "initials": "D"}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "COVAD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-08-14", "journal": {"title": "Rheumatol Int", "issn": "1437-160X", "issn-l": null}, "abstract": "Vaccine hesitancy is considered a major barrier to achieving herd immunity against COVID-19. While multiple alternative and synergistic approaches including heterologous vaccination, booster doses, and antiviral drugs have been developed, equitable vaccine uptake remains the foremost strategy to manage pandemic. Although none of the currently approved vaccines are live-attenuated, several reports of disease flares, waning protection, and acute-onset syndromes have emerged as short-term adverse events after vaccination. Hence, scientific literature falls short when discussing potential long-term effects in vulnerable cohorts. The COVAD-2 survey follows on from the baseline COVAD-1 survey with the aim to collect patient-reported data on the long-term safety and tolerability of COVID-19 vaccines in immune modulation. The e-survey has been extensively pilot-tested and validated with translations into multiple languages. Anticipated results will help improve vaccination efforts and reduce the imminent risks of COVID-19 infection, especially in understudied vulnerable groups.", "doi": "10.1007/s00296-022-05157-6", "pmid": "35964271", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00296-022-05157-6"}], "notes": [], "created": "2022-08-16T15:38:25.072Z", "modified": "2022-08-16T15:38:25.387Z"}, {"entity": "publication", "iuid": "28fe8f3c19a34e55be3411e073c704a5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/28fe8f3c19a34e55be3411e073c704a5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/28fe8f3c19a34e55be3411e073c704a5"}}, "title": "Formation of eicosanoids and other oxylipins in human macrophages.", "authors": [{"family": "Radmark", "given": "Olof", "initials": "O"}], "type": "journal article", "published": "2022-08-13", "journal": {"title": "Biochem Pharmacol", "issn": "1873-2968", "pages": "115210", "issn-l": null}, "abstract": "In this review it is attempted to summarize current studies about formation of eicosanoids and other oxylipins in different human macrophages. There are several reports on M1 and M2 cells, also other phenotypes have been described. The eicosanoids formed in the largest amounts are the COX products TxB2 and PGE2. Thus shortlived bioactive TxA2 is a dominating product both in M1- and in M2-lineages, one exception seems to be MGM-CSF, TGF\u03b2 cells. 5-LOX products are produced in both M1 and M2 macrophages, as well as in not fully polarized cells of both lineages. MM-CSF as well as M2 macrophages produced LTC4 more readily compared to M1 lineage cells. In MGM-CSF, TGF\u03b2 cells LTB4 is a major eicosanoid, in line with high expression of LTA4 hydrolase. Recent reports described increased formation of leukotrienes in macrophages subjected to trained immunity with inflammatory transcriptional reprogramming. Also in macrophages derived from monocytes collected from post-COVID-19 patients. 15-LOX-1 is strongly upregulated in CD206+ M2 cells (M2a), differentiated in presence of IL-4. These macrophages also express 15-LOX-2. In incubations with pathogenic E. coli as well as other stimuli 15(S)-HETE and 17(S)-HDHA were major oxylipins formed. Also, the SPM precursor 5,15-diHETE and the SPM RvD5 were produced in considerable amounts, while other SPMs were less abundant. In M2 macrophages incubated with E. coli or S. aureus the cytosolic 15-LOX-1 enzyme accumulated to punctuate structures in a Ca2+ dependent manner with a relatively slow time course, leading to formation of mediators from endogenous substrate. Chalcones, flavone-like anti-inflammatory natural products, induced translocation of 15-LOX-1 in M2 cells, with high formation of 15-LOX derived oxylipins.", "doi": "10.1016/j.bcp.2022.115210", "pmid": "35973581", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0006-2952(22)00304-5"}], "notes": [], "created": "2022-08-17T10:32:10.568Z", "modified": "2022-08-19T05:25:17.438Z"}, {"entity": "publication", "iuid": "4b8dde812e5f412fa4721dd0055a0926", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b8dde812e5f412fa4721dd0055a0926.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b8dde812e5f412fa4721dd0055a0926"}}, "title": "Association between use of novel glucose-lowering drugs and COVID-19 hospitalization and death in patients with type 2 diabetes: a nationwide registry analysis.", "authors": [{"family": "Ferrannini", "given": "Giulia", "initials": "G", "orcid": "0000-0002-0318-7435", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/378055a26c2c4adaa9068e96f58657fd.json"}}, {"family": "Lund", "given": "Lars H", "initials": "LH", "orcid": "0000-0003-1411-4482", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d9e6ace88b04d23ad1778c4c9d9a425.json"}}, {"family": "Benson", "given": "Lina", "initials": "L"}, {"family": "Rizzo", "given": "Manfredi", "initials": "M", "orcid": "0000-0002-9549-8504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d888593722ae4ba2b12a04effd67eaff.json"}}, {"family": "Almahmeed", "given": "Wael", "initials": "W"}, {"family": "Rosano", "given": "Giuseppe M C", "initials": "GMC"}, {"family": "Savarese", "given": "Gianluigi", "initials": "G"}, {"family": "Cosentino", "given": "Francesco", "initials": "F", "orcid": "0000-0002-6967-5685", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/992ccaa4fa4341379b1932bc0b6d1193.json"}}], "type": "journal article", "published": "2022-08-13", "journal": {"title": "Eur Heart J Cardiovasc Pharmacother", "issn": "2055-6845", "issn-l": "2055-6837"}, "abstract": "Type 2 diabetes (T2DM) in patients with coronavirus disease-19 (COVID-19) is associated with worse prognosis. We separately investigated the associations between the use of sodium-glucose cotransporter 2 inhibitors (SGLT2i), glucagon-like peptide-1 receptor agonists (GLP-1 RA) and dipeptidyl peptidase-4 inhibitors (DPP-4i), and the risk of COVID-19 hospitalization and death.\n\nPatients with T2DM registered in the Swedish National Patient Registry and alive on 1st February 2020 were included. \"Incident severe COVID-19\" was defined as the first hospitalization and/or death from COVID-19. A modified Poisson regression approach was applied to a 1:1 propensity score-matched population receiving vs. not receiving SGLT2i, GLP-1 RA and DPP-4i to analyze the associations between their use and I) incident severe COVID-19, II) risk of 30-day mortality in patients hospitalized for COVID-19.Among 344,413 patients, 39,172 (11%) were treated with SGLT2i, 34,290 (10%) with GLP-1 RA and 53,044 (15%) with DPP-4i; 9,538 (2.8%) had incident severe COVID-19 by 15th May 2021. SGLT2i and DPP-4i were associated with a 10% and 11% higher risk of incident severe COVID-19, respectively, whereas there was no association for GLP-1 RA. DPP-4i were also associated with a 10% higher 30-day mortality in patients hospitalized for COVID-19, whereas there was no association for SGLT2i and GLP-1 RA.\n\nSGLT2i and DPP-4i use was associated with higher risk of incident severe COVID-19. DPP-4i use was associated with higher 30-day mortality in patients with COVID-19, whereas SGLT2i use was not. No increased risk for any outcome was observed with GLP-1 RA.", "doi": "10.1093/ehjcvp/pvac044", "pmid": "35963647", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6665927"}], "notes": [], "created": "2022-08-16T15:38:39.733Z", "modified": "2022-08-16T15:38:39.887Z"}, {"entity": "publication", "iuid": "8c8ce2d05d554dc48bcb8c348f5b65f3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c8ce2d05d554dc48bcb8c348f5b65f3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c8ce2d05d554dc48bcb8c348f5b65f3"}}, "title": "Dispositional optimism and all-cause mortality after esophageal cancer surgery: a nationwide population-based cohort study.", "authors": [{"family": "Liu", "given": "Yangjun", "initials": "Y"}, {"family": "Pettersson", "given": "Erik", "initials": "E"}, {"family": "Schandl", "given": "Anna", "initials": "A"}, {"family": "Markar", "given": "Sheraz", "initials": "S"}, {"family": "Johar", "given": "Asif", "initials": "A"}, {"family": "Lagergren", "given": "Pernilla", "initials": "P"}], "type": "journal article", "published": "2022-08-11", "journal": {"title": "Support Care Cancer", "issn": "1433-7339", "issn-l": null}, "abstract": "To examine the association between dispositional optimism and all-cause mortality after esophageal cancer surgery and whether pathological tumor stage and the COVID-19 pandemic modified this association.\n\nThis nationwide, population-based prospective cohort study included 335 patients undergoing esophageal cancer surgery in Sweden between January 1, 2013, and December 31, 2019. Dispositional optimism was measured 1 year post-surgery using Life Orientation Test-Revised (LOT-R). A higher LOT-R sum score represents higher dispositional optimism. Mortality information was obtained from the Swedish Register of the Total Population. All patients were followed up until death or until December 31, 2020, whichever occurred first. Cox regression with adjustments for confounders was used.\n\nThe median follow-up was 20.8 months, during which 125 (37.3%) patients died. Among the included 335 patients, 219 (65.4%) patients had tumor pathologically staged Tis-II, and 300 (89.6%) patients entered the cohort before the COVID-19 pandemic. Both tumor stage and the COVID-19 pandemic were effect modifiers. For each unit increase in LOT-R sum score, the risk of all-cause mortality decreased by 11% (HR 0.89, 95% CI 0.81 to 0.98) among patients with tumor staged Tis-II before the COVID-19 pandemic. This association was non-significant in patients with tumor staged III-IV (HR 0.99, 95% CI 0.92 to 1.07) and during the COVID-19 pandemic (HR 1.08, 95% CI 0.94 to 1.25).\n\nAssessing dispositional optimism may help predict postoperative survival, especially for patients with early and intermediate esophageal cancer. Increasing dispositional optimism might be a potential intervention target to improve survival after esophageal cancer surgery.", "doi": "10.1007/s00520-022-07311-z", "pmid": "35953730", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00520-022-07311-z"}, {"db": "pmc", "key": "PMC9371627"}], "notes": [], "created": "2022-08-16T15:43:14.451Z", "modified": "2022-08-16T15:43:28.384Z"}, {"entity": "publication", "iuid": "d429910ab03c4043b50f3a1a01eb6816", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d429910ab03c4043b50f3a1a01eb6816.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d429910ab03c4043b50f3a1a01eb6816"}}, "title": "Children in the household and risk of severe COVID-19 during the first three waves of the pandemic: a prospective registry-based cohort study of 1.5 million Swedish men.", "authors": [{"family": "Af Geijerstam", "given": "Agnes", "initials": "A", "orcid": "0000-0002-0897-6548", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ab4ce35a27d446da006cd3aece117c2.json"}}, {"family": "Mehlig", "given": "Kirsten", "initials": "K"}, {"family": "Hunsberger", "given": "Monica", "initials": "M"}, {"family": "\u00c5berg", "given": "Maria", "initials": "M"}, {"family": "Lissner", "given": "Lauren", "initials": "L"}], "type": "journal article", "published": "2022-08-11", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "8", "pages": "e063640", "issn-l": "2044-6055"}, "abstract": "To investigate whether Swedish men living with children had elevated risk for severe COVID-19 or infection with SARS-CoV-2 during the first three waves of the pandemic.\n\nProspective registry-based cohort study.\n\n1 557 061 Swedish men undergoing military conscription between 1968 and 2005 at a mean age of 18.3 (SD 0.73) years.\n\nInfection with SARS-CoV-2 and hospitalisation due to COVID-19 from March 2020 to September 2021.\n\nThere was a protective association between preschool children at home and hospitalisation due to COVID-19 during the first and third waves compared with only older or no children at all, with ORs (95% CIs) 0.63 (0.46 to 0.88) and 0.75 (0.68 to 0.94) respectively. No association was observed for living with children 6-12 years old, but for 13-17 years old, the risk increased. Age in 2020 did not explain these associations. Further adjustment for socioeconomic and health factors did not attenuate the results. Exposure to preschool children also had a protective association with testing positive with SARS-CoV-2, with or without hospitalisation, OR=0.91 (95% CI 0.89 to 0.93), while living with children of other ages was associated with increased odds of infection.\n\nCohabiting with preschool children was associated with reduced risk for severe COVID-19. Living with school-age children between 6 and 12 years had no association with severe COVID-19, but sharing the household with teenagers and young adults was associated with elevated risk. Our results are of special interest since preschools and compulsory schools (age 6-15 years) in Sweden did not close in 2020.", "doi": "10.1136/bmjopen-2022-063640", "pmid": "35953248", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2022-063640"}], "notes": [], "created": "2022-08-12T08:29:46.779Z", "modified": "2022-08-12T08:30:25.309Z"}, {"entity": "publication", "iuid": "4ffb1f30bb7b4f93a2b968c49c876566", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ffb1f30bb7b4f93a2b968c49c876566.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ffb1f30bb7b4f93a2b968c49c876566"}}, "title": "A Worldwide Survey of Activities and Practices in Clinical Islet of Langerhans Transplantation.", "authors": [{"family": "Berney", "given": "Thierry", "initials": "T"}, {"family": "Andres", "given": "Axel", "initials": "A"}, {"family": "Bellin", "given": "Melena D", "initials": "MD"}, {"family": "de Koning", "given": "Eelco J P", "initials": "EJP"}, {"family": "Johnson", "given": "Paul R V", "initials": "PRV"}, {"family": "Kay", "given": "Thomas W H", "initials": "TWH"}, {"family": "Lundgren", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Rickels", "given": "Michael R", "initials": "MR"}, {"family": "Scholz", "given": "Hanne", "initials": "H"}, {"family": "Stock", "given": "Peter G", "initials": "PG"}, {"family": "White", "given": "Steve", "initials": "S"}, {"family": "International Islet Transplant Centers", "given": "", "initials": ""}], "type": "journal article", "published": "2022-08-11", "journal": {"title": "Transpl Int", "issn": "1432-2277", "volume": "35", "pages": "10507", "issn-l": null}, "abstract": "A global online survey was administered to 69 islet transplantation programs, covering 84 centers and 5 networks. The survey addressed questions on program organization and activity in the 2000-2020 period, including impact on activity of national health care coverage policies. We obtained full data from 55 institutions or networks worldwide and basic activity data from 6 centers. Additional data were obtained from alternative sources. A total of 94 institutions and 5 networks was identified as having performed islet allotransplantation. 4,365 islet allotransplants (2,608 in Europe, 1,475 in North America, 135 in Asia, 119 in Oceania, 28 in South America) were reported in 2,170 patients in the survey period. From 15 centers active at the start of the study period, the number of simultaneously active islet centers peaked at 54, to progressively decrease to 26 having performed islet allotransplants in 2020. Notably, only 16 centers/networks have done >100 islet allotransplants in the survey period. Types of transplants performed differed notably between North America and the rest of the world, in particular with respect to the near-absence of simultaneous islet-kidney transplantation. Absence of heath care coverage has significantly hampered transplant activity in the past years and the COVID-19 pandemic in 2020.", "doi": "10.3389/ti.2022.10507", "pmid": "36033644", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10507"}, {"db": "pmc", "key": "PMC9402897"}], "notes": [], "created": "2022-10-07T12:44:10.197Z", "modified": "2022-10-07T12:44:10.210Z"}, {"entity": "publication", "iuid": "d9754f165def4dd7a095cb943ff195d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d9754f165def4dd7a095cb943ff195d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d9754f165def4dd7a095cb943ff195d5"}}, "title": "Lung perfusion disturbances in non-hospitalized post-COVID with dyspnea - An MRI feasibility study.", "authors": [{"family": "Yu", "given": "Jimmy", "initials": "J", "orcid": "0000-0002-7744-3251", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed9b255a526c48b8977e46a0c3931ce3.json"}}, {"family": "Granberg", "given": "Tobias", "initials": "T", "orcid": "0000-0001-6700-1022", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9650681881d442895c1c60fdb49677e.json"}}, {"family": "Shams", "given": "Roya", "initials": "R"}, {"family": "Petersson", "given": "Sven", "initials": "S"}, {"family": "Sk\u00f6ld", "given": "Magnus", "initials": "M"}, {"family": "Nyr\u00e9n", "given": "Sven", "initials": "S"}, {"family": "Lundberg", "given": "Johan", "initials": "J", "orcid": "0000-0003-2379-8695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/488ece97feee4422994105a3b4c05e94.json"}}], "type": "journal article", "published": "2022-08-10", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null}, "abstract": "Dyspnea is common after COVID-19. Though the underlying mechanisms are largely unknown, lung perfusion abnormalities could contribute to lingering dyspnea.\n\nTo detect pulmonary perfusion disturbances in non-hospitalized individuals with post-COVID condition and persistent dyspnea 4-13 months after the disease onset.\n\nIndividuals with dyspnea and matched healthy controls were recruited for dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), a six-minute walk test, and an assessment of dyspnea. The DCE-MRI was quantified using two parametric values: mean time-to-peak (TTP) and TTP ratio, reflecting the total lung perfusion resistance and the fraction of lung with delayed perfusion, respectively.\n\nTwenty-eight persons with persistent dyspnea (mean age 46.5\u00b18.0 years, 75% women) and 22 controls (mean age 44.1\u00b110.8 years, 73% women) were included. There was no systematic sex difference in dyspnea. The post-COVID group had no focal perfusion deficits but had higher mean pulmonary TTP (0.43\u00b10.04 vs. 0.41\u00b10.03, P = 0.011) and TTP ratio (0.096\u00b10.052 vs. 0.068\u00b10.027, P = 0.032). Post-COVID males had the highest mean TTP 0.47\u00b10.02 and TTP ratio of 0.160\u00b10.039; compared to male controls and post-COVID females (P = 0.001 and P<0.001 respectively). Correlations between dyspnea and perfusion parameters were demonstrated in males (r = 0.83, P<0.001 for mean TTP; r = 0.76, P = 0.003 for TTP ratio), but not in females.\n\nDCE-MRI demonstrated late contrast bolus arrival in males with post-COVID dyspnea, suggestive of primary vascular lesions or secondary effects of hypoxic vasoconstriction. Since this effect was not regularly observed in female patients, our findings suggest sex differences in the mechanisms underlying post-COVID dyspnea, which warrants further investigation in dedicated trials. This article is protected by copyright. All rights reserved.", "doi": "10.1111/joim.13558", "pmid": "35946904", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-11T11:48:35.115Z", "modified": "2022-08-11T11:48:49.758Z"}, {"entity": "publication", "iuid": "1b8ce8c8a35543d9aaa04b01b5220449", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b8ce8c8a35543d9aaa04b01b5220449.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b8ce8c8a35543d9aaa04b01b5220449"}}, "title": "Employees Perception of Organizational Crises and Their Reactions to Them - A Norwegian Organizational Case Study.", "authors": [{"family": "S\u00f8rensen", "given": "Jarle L\u00f8we", "initials": "JL"}, {"family": "Ranse", "given": "Jamie", "initials": "J"}, {"family": "Gray", "given": "Lesley", "initials": "L"}, {"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}, {"family": "Hertelendy", "given": "Attila J", "initials": "AJ"}], "type": "journal article", "published": "2022-08-10", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "13", "pages": "818422", "issn-l": "1664-1078"}, "abstract": "Organizational sensemaking is crucial for resource planning and crisis management since facing complex strategic problems that exceed their capacity and ability, such as crises, forces organizations to engage in inter-organizational collaboration, which leads to obtaining individual and diverse perspectives to comprehend the issues and find solutions. This online qualitative survey study examines how Norwegian Sea Rescue Society employees perceived the concept of an organizational crisis and how they sensed their co-workers react to it. The scope was the ongoing COVID-19 pandemic, a global event affecting all countries and organizations and responding similarly globally. Data were collected during the Fall of 2020. The instrument of choice was the Internal Crisis Management and Crisis Communication survey (ICMCC). The results showed that the overall sample strongly believed in their organization's overall resilience level. However, a somewhat vague understanding of roles and responsibilities in a crisis where detected, together with some signs of informal communication, rumor spreading, misunderstanding, frustration, and insecurity. This study contributes to the academic field of organizational research, hence crisis management and sensemaking, and could be valuable to managers and decision-makers across sectors. Increased knowledge about how employees react to a crisis may help optimize internal crisis management planning and utilize robust mitigation and response strategies.", "doi": "10.3389/fpsyg.2022.818422", "pmid": "36033100", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9400917"}], "notes": [], "created": "2022-10-07T12:42:32.862Z", "modified": "2022-10-07T12:42:46.047Z"}, {"entity": "publication", "iuid": "bbee8ac14a4647fa850d618ac85e8671", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bbee8ac14a4647fa850d618ac85e8671.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bbee8ac14a4647fa850d618ac85e8671"}}, "title": "Predictors of post-COVID-19 and the impact of persistent symptoms in non-hospitalized patients 12 months after COVID-19, with a focus on work ability.", "authors": [{"family": "Kisiel", "given": "Marta A", "initials": "MA"}, {"family": "Janols", "given": "Helena", "initials": "H"}, {"family": "Nordqvist", "given": "Tobias", "initials": "T"}, {"family": "Bergquist", "given": "Jonas", "initials": "J"}, {"family": "Hagfeldt", "given": "Simone", "initials": "S"}, {"family": "Malinovschi", "given": "Andrei", "initials": "A"}, {"family": "Svartengren", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2022-08-09", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "volume": "127", "issn-l": "0300-9734"}, "abstract": "Better knowledge of long-term symptoms following coronavirus disease 2019 (COVID-19), the so-called post-COVID-19, in non-hospitalized patients is needed. The aim of this study was to study persisent symptoms up to 12 months after COVID-19 in non-hospitalized patients and their impact on work ability. We also investigated predictors of persistent symptoms.\n\nThis study encompassed non-hospitalized adult subjects with a COVID-19 infection confirmed via positive nasopharyngeal swab polymerase chain reaction test during the first wave of the pandemic in Uppsala, Sweden. In total, 566 subjects were sent a survey via e-mail or post with an invitation to participate in the survey 12 months post-diagnosis. The majority of subjects were healthcare workers, as this group was prioritized for testing.\n\nA total of 366 subjects responded, with 47% reporting persistent symptoms 12 months after their COVID-19 diagnosis. The most commonly reported symptoms at this time were impaired sense of smell and/or taste and fatigue. Among the predictors of persistent symptoms were being born abroad, lower physical fitness compared with peers before COVID-19, body mass index >25 kg/m2, cooccurrence of hypertension and chronic pain, and having more than seven of the general COVID-19 symptoms at the onset. Respondents with symptoms after 12 months self-reported negatively about their general health and work ability.\n\nThis study indicated that many people who had mild COVID-19 might have a variety of long-term symptoms. It highlights the importance of considering work ability after mild COVID-19.", "doi": "10.48101/ujms.v127.8794", "pmid": "35991464", "labels": {"Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "8794"}, {"db": "pmc", "key": "PMC9383047"}], "notes": [], "created": "2022-09-12T18:51:48.050Z", "modified": "2022-09-12T18:51:48.079Z"}, {"entity": "publication", "iuid": "5b708890ca7a417f9358dc27e7737fd6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5b708890ca7a417f9358dc27e7737fd6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5b708890ca7a417f9358dc27e7737fd6"}}, "title": "Fear of COVID-19 Among Patients with Inflammatory Bowel Disease as Compared to Patients with Other Gastrointestinal Conditions.", "authors": [{"family": "Lo", "given": "Bobby", "initials": "B"}, {"family": "Barreiro-de Acosta", "given": "Manuel", "initials": "M"}, {"family": "Bernstein", "given": "Charles N", "initials": "CN"}, {"family": "Burisch", "given": "Johan", "initials": "J"}, {"family": "Ferreira", "given": "Nuno", "initials": "N"}, {"family": "Gearry", "given": "Richard B", "initials": "RB"}, {"family": "Mikocka-Walus", "given": "Antonina", "initials": "A"}, {"family": "Mokrowiecka", "given": "Anna", "initials": "A"}, {"family": "Trindade", "given": "In\u00eas A", "initials": "IA"}, {"family": "Knowles", "given": "Simon R", "initials": "SR"}], "type": "journal article", "published": "2022-08-09", "journal": {"title": "Turk J Gastroenterol", "issn": "2148-5607", "issn-l": null}, "abstract": "Although several studies have reported the impact of fears relating to coronavirus-19 on several chronic illnesses, there are few studies focused on gastrointestinal conditions. Therefore, the aim of this study was to compare the fear of coronavirus-19 in patients with inflammatory bowel disease to other gastrointestinal conditions and how the fear of COVID-19 manifests across different demographical backgrounds among inflammatory bowel disease respondents.\n\nParticipants with gastrointestinal conditions (age \u2265 18) were recruited from 27 countries. Demographic, clinical, and psycho- social information was collected. An adapted scale for inflammatory bowel disease patients measuring the fear of coronavirus-19 and gastrointestinal-specific fear of coronavirus-19 was used.\n\nIn 831 participants (312 inflammatory bowel disease), only significant increases in gastrointestinal-fear of coronavirus-19 were found in between inflammatory bowel disease and other gastrointestinal conditions (mean [standard deviation]: 13.5 [5.5] vs 10.9 [5.0], P < .01). Among inflammatory bowel disease respondents, persons on sick leave had significantly more fear of coronavirus-19 than those employed (median [IQR], 31.0 [28.5-39.5] vs 26.0 [20.0-33.0], P = .035) and significantly more gastrointestinal-fear of coro- navirus-19 compared to the employed (18.0 [14.5-22.0] vs 13.0 [9.0-17.0], P = .033) or respondents outside of the labor market (12.0 [7.0-16.0], P = .022). Persons living in a rural setting had significantly more fear of coronavirus-19 compared to persons living in regional setting (29.5 [22.0-37.8] vs 25.0 [20.0-31.3], P = .007) and gastrointestinal-fear of coronavirus-19 (15.0 [11.0-19.8] vs 12.0 [9.0-16.0], P = .02).\n\nRespondents with inflammatory bowel disease are more afraid of coronavirus-19 regarding their disease; especially, per- sons on sick leave or persons living in a rural setting. This should be taken into consideration to personalize the support that health care providers can offer in mitigating fear related to coronavirus-19.", "doi": "10.5152/tjg.2022.21774", "pmid": "35943147", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-11T11:49:37.856Z", "modified": "2022-08-11T11:49:37.892Z"}, {"entity": "publication", "iuid": "6a5ff6060a664312acc7a73a2682bba6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a5ff6060a664312acc7a73a2682bba6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a5ff6060a664312acc7a73a2682bba6"}}, "title": "Ethnic, racial and regional inequalities in access to COVID-19 vaccine, testing and hospitalization: Implications for eradication of the pandemic.", "authors": [{"family": "Ahlberg", "given": "Beth Maina", "initials": "BM"}, {"family": "Bradby", "given": "Hannah", "initials": "H"}], "type": "journal article", "published": "2022-08-09", "journal": {"title": "Front Sociol", "issn": "2297-7775", "volume": "7", "pages": "809090", "issn-l": null}, "abstract": "The COVID-19 pandemic has made visible inequalities as exemplified by unequal access to COVID-19 vaccine across and within countries; inequalities that are also apparent in rates of testing, disease, hospitalization and death from COVID-19 along class, ethnic and racial lines. For a global pandemic such as the COVID-19 to be effectively addressed, there is a need to reflect on the entrenched and structural inequalities within and between countries. While many countries in the global north have acquired more vaccines than they may need, in the global south many have very limited access. While countries in the global north had largely vaccinated their populations by 2022, those in the global south may not even complete vaccinating 70% of their population to enable them reach the so-called herd immunity by 2024. Even in the global north where vaccines are available, ethnic, racialized and poor working classes are disproportionately affected in terms of disproportionately low rates of infection and death. This paper explores the socio-economic and political structural factors that have created and maintain these disparities. In particular we sketch the role of neoliberal developments in deregulating and financializing the system, vaccine hoarding, patent protection and how this contributes to maintaining and widening disparities in access to COVID-19 vaccine and medication.", "doi": "10.3389/fsoc.2022.809090", "pmid": "36017478", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9396233"}], "notes": [], "created": "2022-09-12T19:14:28.562Z", "modified": "2022-09-12T19:14:49.442Z"}, {"entity": "publication", "iuid": "22834b2fed9548b3bb79b639f1a3d7ab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/22834b2fed9548b3bb79b639f1a3d7ab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/22834b2fed9548b3bb79b639f1a3d7ab"}}, "title": "T cell perturbations persist for at least 6 months following hospitalization for COVID-19.", "authors": [{"family": "Govender", "given": "Melissa", "initials": "M"}, {"family": "Hopkins", "given": "Francis R", "initials": "FR"}, {"family": "G\u00f6ransson", "given": "Robin", "initials": "R"}, {"family": "Svanberg", "given": "Cecilia", "initials": "C"}, {"family": "Shankar", "given": "Esaki M", "initials": "EM"}, {"family": "Hjorth", "given": "Maria", "initials": "M"}, {"family": "Nilsdotter-Augustinsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Sj\u00f6wall", "given": "Johanna", "initials": "J"}, {"family": "Nystr\u00f6m", "given": "Sofia", "initials": "S"}, {"family": "Larsson", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2022-08-08", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "13", "pages": "931039", "issn-l": "1664-3224"}, "abstract": "COVID-19 is being extensively studied, and much remains unknown regarding the long-term consequences of the disease on immune cells. The different arms of the immune system are interlinked, with humoral responses and the production of high-affinity antibodies being largely dependent on T cell immunity. Here, we longitudinally explored the effect COVID-19 has on T cell populations and the virus-specific T cells, as well as neutralizing antibody responses, for 6-7 months following hospitalization. The CD8+ TEMRA and exhausted CD57+ CD8+ T cells were markedly affected with elevated levels that lasted long into convalescence. Further, markers associated with T cell activation were upregulated at inclusion, and in the case of CD69+ CD4+ T cells this lasted all through the study duration. The levels of T cells expressing negative immune checkpoint molecules were increased in COVID-19 patients and sustained for a prolonged duration following recovery. Within 2-3 weeks after symptom onset, all COVID-19 patients developed anti-nucleocapsid IgG and spike-neutralizing IgG as well as SARS-CoV-2-specific T cell responses. In addition, we found alterations in follicular T helper (TFH) cell populations, such as enhanced TFH-TH2 following recovery from COVID-19. Our study revealed significant and long-term alterations in T cell populations and key events associated with COVID-19 pathogenesis.", "doi": "10.3389/fimmu.2022.931039", "pmid": "36003367", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9393525"}], "notes": [], "created": "2022-08-26T04:42:30.271Z", "modified": "2022-08-26T04:42:30.286Z"}, {"entity": "publication", "iuid": "c5087e20c8ef4b42b7b9db2e05de09bc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5087e20c8ef4b42b7b9db2e05de09bc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5087e20c8ef4b42b7b9db2e05de09bc"}}, "title": "Global statements to produce and implement evidence in the post-COVID-19 era provide a path forward for rehabilitation - A joint initiative of Cochrane Rehabilitation and the leading journals in the field.", "authors": [{"family": "Negrini", "given": "Stefano", "initials": "S"}, {"family": "Borg", "given": "Kristian", "initials": "K"}, {"family": "Cusick", "given": "Anne", "initials": "A"}, {"family": "Ferriero", "given": "Giorgio", "initials": "G"}, {"family": "Frontera", "given": "Walter R", "initials": "WR"}, {"family": "Gross", "given": "Douglas P", "initials": "DP"}, {"family": "Heinemann", "given": "Allen", "initials": "A"}, {"family": "Machalicek", "given": "Wendy", "initials": "W"}, {"family": "Moore", "given": "Ann Patricia", "initials": "AP"}, {"family": "Nudo", "given": "Randolph J", "initials": "RJ"}, {"family": "P\u00e9rennou", "given": "Dominic", "initials": "D"}, {"family": "Stam", "given": "Henk", "initials": "H"}, {"family": "Kiekens", "given": "Carlotte", "initials": "C"}], "type": "editorial", "published": "2022-08-08", "journal": {"title": "Ann Phys Rehabil Med", "issn": "1877-0665", "volume": "65", "issue": "5", "pages": "101688", "issn-l": null}, "abstract": null, "doi": "10.1016/j.rehab.2022.101688", "pmid": "35811074", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1877-0657(22)00060-4"}, {"db": "pmc", "key": "PMC9359696"}], "notes": [], "created": "2022-08-17T10:39:30.587Z", "modified": "2022-08-17T10:39:30.623Z"}, {"entity": "publication", "iuid": "0b5b126f50454bbc9c63c07953df7ef6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b5b126f50454bbc9c63c07953df7ef6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b5b126f50454bbc9c63c07953df7ef6"}}, "title": "DOCK2 is involved in the host genetics and biology of severe COVID-19.", "authors": [{"family": "Namkoong", "given": "Ho", "initials": "H"}, {"family": "Edahiro", "given": "Ryuya", "initials": "R"}, {"family": "Takano", "given": "Tomomi", "initials": "T", "orcid": "0000-0002-3468-0708", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adde787b5bc444f0a112ba88082598b6.json"}}, {"family": "Nishihara", "given": "Hiroshi", "initials": "H"}, {"family": "Shirai", "given": "Yuya", "initials": "Y"}, {"family": "Sonehara", "given": "Kyuto", "initials": "K"}, {"family": "Tanaka", "given": "Hiromu", "initials": "H"}, {"family": "Azekawa", "given": "Shuhei", "initials": "S"}, {"family": "Mikami", "given": "Yohei", "initials": "Y", "orcid": "0000-0001-5104-4415", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/973a5f4549f34bd48380bb590c496dc1.json"}}, {"family": "Lee", "given": "Ho", "initials": "H"}, {"family": "Hasegawa", "given": "Takanori", "initials": "T"}, {"family": "Okudela", "given": "Koji", "initials": "K"}, {"family": "Okuzaki", "given": "Daisuke", "initials": "D", "orcid": "0000-0002-4552-783X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ccf9bee61674fe38e3acf6221678f35.json"}}, {"family": "Motooka", "given": "Daisuke", "initials": "D"}, {"family": "Kanai", "given": "Masahiro", "initials": "M", "orcid": "0000-0001-5165-4408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01d858a30cea453d91cedab1fd5c8494.json"}}, {"family": "Naito", "given": "Tatsuhiko", "initials": "T", "orcid": "0000-0002-2779-4600", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b0897a4c92b4ca781c81fc0d5520385.json"}}, {"family": "Yamamoto", "given": "Kenichi", "initials": "K", "orcid": "0000-0001-9594-7050", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d494d739ff8469c9f6def67c94cb3ef.json"}}, {"family": "Wang", "given": "Qingbo S", "initials": "QS"}, {"family": "Saiki", "given": "Ryunosuke", "initials": "R", "orcid": "0000-0001-6984-7187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd5bae576b614b1f9e27c3975f2f72a2.json"}}, {"family": "Ishihara", "given": "Rino", "initials": "R", "orcid": "0000-0002-1312-6732", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d8a7f8f668d4e7989545df4ce82f649.json"}}, {"family": "Matsubara", "given": "Yuta", "initials": "Y"}, {"family": "Hamamoto", "given": "Junko", "initials": "J"}, {"family": "Hayashi", "given": "Hiroyuki", "initials": "H"}, {"family": "Yoshimura", "given": "Yukihiro", "initials": "Y"}, {"family": "Tachikawa", "given": "Natsuo", "initials": "N"}, {"family": "Yanagita", "given": "Emmy", "initials": "E"}, {"family": "Hyugaji", "given": "Takayoshi", "initials": "T"}, {"family": "Shimizu", "given": "Eigo", "initials": "E"}, {"family": "Katayama", "given": "Kotoe", "initials": "K", "orcid": "0000-0002-3966-1231", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68f93c3d200e45cea3eaea3a1758f0af.json"}}, {"family": "Kato", "given": "Yasuhiro", "initials": "Y"}, {"family": "Morita", "given": "Takayoshi", "initials": "T"}, {"family": "Takahashi", "given": "Kazuhisa", "initials": "K"}, {"family": "Harada", "given": "Norihiro", "initials": "N"}, {"family": "Naito", "given": "Toshio", "initials": "T"}, {"family": "Hiki", "given": "Makoto", "initials": "M"}, {"family": "Matsushita", "given": "Yasushi", "initials": "Y"}, {"family": "Takagi", "given": "Haruhi", "initials": "H"}, {"family": "Aoki", "given": "Ryousuke", "initials": "R"}, {"family": "Nakamura", "given": "Ai", "initials": "A"}, {"family": "Harada", "given": "Sonoko", "initials": "S"}, {"family": "Sasano", "given": "Hitoshi", "initials": "H"}, {"family": "Kabata", "given": "Hiroki", "initials": "H"}, {"family": "Masaki", "given": "Katsunori", "initials": "K"}, {"family": "Kamata", "given": "Hirofumi", "initials": "H"}, {"family": "Ikemura", "given": "Shinnosuke", "initials": "S"}, {"family": "Chubachi", "given": "Shotaro", "initials": "S"}, {"family": "Okamori", "given": "Satoshi", "initials": "S"}, {"family": "Terai", "given": "Hideki", "initials": "H"}, {"family": "Morita", "given": "Atsuho", "initials": "A"}, {"family": "Asakura", "given": "Takanori", "initials": "T"}, {"family": "Sasaki", "given": "Junichi", "initials": "J"}, {"family": "Morisaki", "given": "Hiroshi", "initials": "H"}, {"family": "Uwamino", "given": "Yoshifumi", "initials": "Y"}, {"family": "Nanki", "given": "Kosaku", "initials": "K"}, {"family": "Uchida", "given": "Sho", "initials": "S"}, {"family": "Uno", "given": "Shunsuke", "initials": "S"}, {"family": "Nishimura", "given": "Tomoyasu", "initials": "T"}, {"family": "Ishiguro", "given": "Takashi", "initials": "T"}, {"family": "Isono", "given": "Taisuke", "initials": "T"}, {"family": "Shibata", "given": "Shun", "initials": "S"}, {"family": "Matsui", "given": "Yuma", "initials": "Y"}, {"family": "Hosoda", "given": "Chiaki", "initials": "C"}, {"family": "Takano", "given": "Kenji", "initials": "K"}, {"family": "Nishida", "given": "Takashi", "initials": "T"}, {"family": "Kobayashi", "given": "Yoichi", "initials": "Y"}, {"family": "Takaku", "given": "Yotaro", "initials": "Y"}, {"family": "Takayanagi", "given": "Noboru", "initials": "N"}, {"family": "Ueda", "given": "Soichiro", "initials": "S"}, {"family": "Tada", "given": "Ai", "initials": "A"}, {"family": "Miyawaki", "given": "Masayoshi", "initials": "M"}, {"family": "Yamamoto", "given": "Masaomi", "initials": "M"}, {"family": "Yoshida", "given": "Eriko", "initials": "E"}, {"family": "Hayashi", "given": "Reina", "initials": "R"}, {"family": "Nagasaka", "given": "Tomoki", "initials": "T"}, {"family": "Arai", "given": "Sawako", "initials": "S"}, {"family": "Kaneko", "given": "Yutaro", "initials": "Y"}, {"family": "Sasaki", "given": "Kana", "initials": "K"}, {"family": "Tagaya", "given": "Etsuko", "initials": "E"}, {"family": "Kawana", "given": "Masatoshi", "initials": "M"}, {"family": "Arimura", "given": "Ken", "initials": "K"}, {"family": "Takahashi", "given": "Kunihiko", "initials": "K"}, {"family": "Anzai", "given": "Tatsuhiko", "initials": "T"}, {"family": "Ito", "given": "Satoshi", "initials": "S"}, {"family": "Endo", "given": "Akifumi", "initials": "A"}, {"family": "Uchimura", "given": "Yuji", "initials": "Y"}, {"family": "Miyazaki", "given": "Yasunari", "initials": "Y"}, {"family": "Honda", "given": "Takayuki", "initials": "T"}, {"family": "Tateishi", "given": "Tomoya", "initials": "T"}, {"family": "Tohda", "given": "Shuji", "initials": "S"}, {"family": "Ichimura", "given": "Naoya", "initials": "N"}, {"family": "Sonobe", "given": "Kazunari", "initials": "K"}, {"family": "Sassa", "given": "Chihiro Tani", "initials": "CT"}, {"family": "Nakajima", "given": "Jun", "initials": "J"}, {"family": "Nakano", "given": "Yasushi", "initials": "Y"}, {"family": "Nakajima", "given": "Yukiko", "initials": "Y"}, {"family": "Anan", "given": "Ryusuke", "initials": "R"}, {"family": "Arai", "given": "Ryosuke", "initials": "R"}, {"family": "Kurihara", "given": "Yuko", "initials": "Y"}, {"family": "Harada", "given": "Yuko", "initials": "Y"}, {"family": "Nishio", "given": "Kazumi", "initials": "K"}, {"family": "Ueda", "given": "Tetsuya", "initials": "T"}, {"family": "Azuma", "given": "Masanori", "initials": "M"}, {"family": "Saito", "given": "Ryuichi", "initials": "R"}, {"family": "Sado", "given": "Toshikatsu", "initials": "T"}, {"family": "Miyazaki", "given": "Yoshimune", "initials": "Y"}, {"family": "Sato", "given": "Ryuichi", "initials": "R"}, {"family": "Haruta", "given": "Yuki", "initials": "Y"}, {"family": "Nagasaki", "given": "Tadao", "initials": "T"}, {"family": "Yasui", "given": "Yoshinori", "initials": "Y"}, {"family": "Hasegawa", "given": "Yoshinori", "initials": "Y"}, {"family": "Mutoh", "given": "Yoshikazu", "initials": "Y"}, {"family": "Kimura", "given": "Tomoki", "initials": "T"}, {"family": "Sato", "given": "Tomonori", "initials": "T"}, {"family": "Takei", "given": "Reoto", "initials": "R"}, {"family": "Hagimoto", "given": "Satoshi", "initials": "S"}, {"family": "Noguchi", "given": "Yoichiro", "initials": "Y"}, {"family": "Yamano", "given": "Yasuhiko", "initials": "Y"}, {"family": "Sasano", "given": "Hajime", "initials": "H"}, {"family": "Ota", "given": "Sho", "initials": "S"}, {"family": "Nakamori", "given": "Yasushi", "initials": "Y"}, {"family": "Yoshiya", "given": "Kazuhisa", "initials": "K"}, {"family": "Saito", "given": "Fukuki", "initials": "F"}, {"family": "Yoshihara", "given": "Tomoyuki", "initials": "T"}, {"family": "Wada", "given": "Daiki", "initials": "D"}, {"family": "Iwamura", "given": "Hiromu", "initials": "H"}, {"family": "Kanayama", "given": "Syuji", "initials": "S"}, {"family": "Maruyama", "given": "Shuhei", "initials": "S"}, {"family": "Yoshiyama", "given": "Takashi", "initials": "T"}, {"family": "Ohta", "given": "Ken", "initials": "K"}, {"family": "Kokuto", "given": "Hiroyuki", "initials": "H"}, {"family": "Ogata", "given": "Hideo", "initials": "H"}, {"family": "Tanaka", "given": "Yoshiaki", "initials": "Y"}, {"family": "Arakawa", "given": "Kenichi", "initials": "K"}, {"family": "Shimoda", "given": "Masafumi", "initials": "M"}, {"family": "Osawa", "given": "Takeshi", "initials": "T"}, {"family": "Tateno", "given": "Hiroki", "initials": "H"}, {"family": "Hase", "given": "Isano", "initials": "I"}, {"family": "Yoshida", "given": "Shuichi", "initials": "S"}, {"family": "Suzuki", "given": "Shoji", "initials": "S"}, {"family": "Kawada", "given": "Miki", "initials": "M"}, {"family": "Horinouchi", "given": "Hirohisa", "initials": "H"}, {"family": "Saito", "given": "Fumitake", "initials": "F"}, {"family": "Mitamura", "given": "Keiko", "initials": "K"}, {"family": "Hagihara", "given": "Masao", "initials": "M"}, {"family": "Ochi", "given": "Junichi", "initials": "J"}, {"family": "Uchida", "given": "Tomoyuki", "initials": "T"}, {"family": "Baba", "given": "Rie", "initials": "R"}, {"family": "Arai", "given": "Daisuke", "initials": "D"}, {"family": "Ogura", "given": "Takayuki", "initials": "T"}, {"family": "Takahashi", "given": "Hidenori", "initials": "H"}, {"family": "Hagiwara", "given": "Shigehiro", "initials": "S"}, {"family": "Nagao", "given": "Genta", "initials": "G"}, {"family": "Konishi", "given": "Shunichiro", "initials": "S"}, {"family": "Nakachi", "given": "Ichiro", "initials": "I"}, {"family": "Murakami", "given": "Koji", "initials": "K"}, {"family": "Yamada", "given": "Mitsuhiro", "initials": "M"}, {"family": "Sugiura", "given": "Hisatoshi", "initials": "H"}, {"family": "Sano", "given": "Hirohito", "initials": "H"}, {"family": "Matsumoto", "given": "Shuichiro", "initials": "S"}, {"family": "Kimura", "given": "Nozomu", "initials": "N"}, {"family": "Ono", "given": "Yoshinao", "initials": "Y"}, {"family": "Baba", "given": "Hiroaki", "initials": "H"}, {"family": "Suzuki", "given": "Yusuke", "initials": "Y"}, {"family": "Nakayama", "given": "Sohei", "initials": "S"}, {"family": "Masuzawa", "given": "Keita", "initials": "K"}, {"family": "Namba", "given": "Shinichi", "initials": "S"}, {"family": "Suzuki", "given": "Ken", "initials": "K"}, {"family": "Naito", "given": "Yoko", "initials": "Y"}, 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"initials": "T"}, {"family": "Amiya", "given": "Saori", "initials": "S"}, {"family": "Hara", "given": "Reina", "initials": "R"}, {"family": "Yamaguchi", "given": "Yuta", "initials": "Y"}, {"family": "Murakami", "given": "Teruaki", "initials": "T"}, {"family": "Kuge", "given": "Tomoki", "initials": "T"}, {"family": "Matsumoto", "given": "Kinnosuke", "initials": "K"}, {"family": "Yamamoto", "given": "Yuji", "initials": "Y"}, {"family": "Yamamoto", "given": "Makoto", "initials": "M"}, {"family": "Yoneda", "given": "Midori", "initials": "M"}, {"family": "Kishikawa", "given": "Toshihiro", "initials": "T"}, {"family": "Yamada", "given": "Shuhei", "initials": "S"}, {"family": "Kawabata", "given": "Shuhei", "initials": "S"}, {"family": "Kijima", "given": "Noriyuki", "initials": "N"}, {"family": "Takagaki", "given": "Masatoshi", "initials": "M"}, {"family": "Sasa", "given": "Noah", "initials": "N"}, {"family": "Ueno", "given": "Yuya", "initials": "Y"}, {"family": "Suzuki", "given": "Motoyuki", 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"Takeru", "initials": "T"}, {"family": "Fujita", "given": "Kazue", "initials": "K"}, {"family": "Saito", "given": "Yoshinobu", "initials": "Y"}, {"family": "Seike", "given": "Masahiro", "initials": "M"}, {"family": "Watanabe", "given": "Hiroko", "initials": "H"}, {"family": "Matsuse", "given": "Hiroto", "initials": "H"}, {"family": "Kodaka", "given": "Norio", "initials": "N"}, {"family": "Nakano", "given": "Chihiro", "initials": "C"}, {"family": "Oshio", "given": "Takeshi", "initials": "T"}, {"family": "Hirouchi", "given": "Takatomo", "initials": "T"}, {"family": "Makino", "given": "Shohei", "initials": "S"}, {"family": "Egi", "given": "Moritoki", "initials": "M"}, {"family": "Biobank Japan Project", "given": "", "initials": ""}, {"family": "Omae", "given": "Yosuke", "initials": "Y"}, {"family": "Nannya", "given": "Yasuhito", "initials": "Y"}, {"family": "Ueno", "given": "Takafumi", "initials": "T", "orcid": "0000-0001-9219-0726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3cc40b72010340a2bba13d406334a1b3.json"}}, {"family": "Katayama", "given": "Kazuhiko", "initials": "K", "orcid": "0000-0002-7692-1151", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2c4b23a809c41d3b080359ad4ee88cd.json"}}, {"family": "Ai", "given": "Masumi", "initials": "M"}, {"family": "Fukui", "given": "Yoshinori", "initials": "Y", "orcid": "0000-0003-2335-8745", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f25a95eb6fc49f9bf216d9c223d6a0d.json"}}, {"family": "Kumanogoh", "given": "Atsushi", "initials": "A", "orcid": "0000-0003-4749-7117", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4565dd205dee4d1fa6644195ece55c6d.json"}}, {"family": "Sato", "given": "Toshiro", "initials": "T", "orcid": "0000-0001-8353-8137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e7a398c59724357ba5a2148184e914a.json"}}, {"family": "Hasegawa", "given": "Naoki", "initials": "N", "orcid": "0000-0003-0717-7450", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8e747324a074632b13eccd27a77b1cc.json"}}, {"family": "Tokunaga", "given": "Katsushi", "initials": "K"}, {"family": "Ishii", "given": "Makoto", "initials": "M", "orcid": "0000-0003-4396-1664", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/baeffc7d32584e36a16ccd0d1d39aeaa.json"}}, {"family": "Koike", "given": "Ryuji", "initials": "R"}, {"family": "Kitagawa", "given": "Yuko", "initials": "Y"}, {"family": "Kimura", "given": "Akinori", "initials": "A"}, {"family": "Imoto", "given": "Seiya", "initials": "S"}, {"family": "Miyano", "given": "Satoru", "initials": "S"}, {"family": "Ogawa", "given": "Seishi", "initials": "S"}, {"family": "Kanai", "given": "Takanori", "initials": "T"}, {"family": "Fukunaga", "given": "Koichi", "initials": "K"}, {"family": "Okada", "given": "Yukinori", "initials": "Y", "orcid": "0000-0002-0311-8472", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/180d7682259f44da968366b41662b959.json"}}], "type": "journal article", "published": "2022-08-08", "journal": {"title": "Nature", "issn": "1476-4687", "issn-l": "0028-0836"}, "abstract": "Identifying the factors underlying severe COVID-19 in the host genetics is an emerging issue1-5. We conducted a genome-wide association study (GWAS) involving 2,393 Japanese COVID-19 cases collected in initial pandemic waves with 3,289 controls, which identified a variant on 5q35 (rs60200309-A) near DOCK2 associated with severe COVID-19 in younger (<65 ages) patients (nCase=440, odds ratio=2.01, P=1.2\u00d710-8). This risk allele was prevalent in East Asians but rare in Europeans, showing a value of non-European GWAS. RNA-seq of 473 bulk peripheral blood identified decreasing effect of the risk allele on DOCK2 expression in younger patients. DOCK2 expression was suppressed in severe forms of COVID-19. Single cell RNA-seq analysis (n=61) identified cell type-specific downregulation of DOCK2 and COVID-19-specific decreasing effects of the risk allele on DOCK2 in non-classical monocytes. Immunohistochemistry of lung specimens from severe COVID-19 pneumonia showed suppressed DOCK2. Moreover, inhibition of DOCK2 function using CPYPP induced much more severe pneumonia in a Syrian hamster model of SARS-CoV-2 infection characterized as weight loss, lung edema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 plays an important role in the host immune response to SARS-CoV-2 infection and development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target.", "doi": "10.1038/s41586-022-05163-5", "pmid": "35940203", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41586-022-05163-5"}], "notes": [], "created": "2022-08-11T11:52:59.253Z", "modified": "2022-08-11T11:52:59.772Z"}, {"entity": "publication", "iuid": "b024bbc25781496fa75cd6860d48563d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b024bbc25781496fa75cd6860d48563d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b024bbc25781496fa75cd6860d48563d"}}, "title": "Coronavirus pandemic in the Nordic countries: Health policy and economy trade-off.", "authors": [{"family": "Irfan", "given": "Furqan B", "initials": "FB"}, {"family": "Minetti", "given": "Raoul", "initials": "R"}, {"family": "Telford", "given": "Ben", "initials": "B"}, {"family": "Ahmed", "given": "Fahad S", "initials": "FS"}, {"family": "Syed", "given": "Ayesha Y", "initials": "AY"}, {"family": "Hollon", "given": "Nick", "initials": "N"}, {"family": "Brauman", "given": "Seth C", "initials": "SC"}, {"family": "Cunningham", "given": "William", "initials": "W"}, {"family": "Awad", "given": "Mohamed E", "initials": "ME"}, {"family": "Saleh", "given": "Khaled J", "initials": "KJ"}, {"family": "Waljee", "given": "Akbar K", "initials": "AK"}, {"family": "Brusselaers", "given": "Nele", "initials": "N"}], "type": "journal article", "published": "2022-08-08", "journal": {"title": "J Glob Health", "issn": "2047-2986", "volume": "12", "pages": "05017", "issn-l": "2047-2978"}, "abstract": "Countries making up the Nordic region - Denmark, Finland, Iceland, Norway, and Sweden - have minimal socioeconomic, cultural, and geographical differences between them, allowing for a fair comparative analysis of the health policy and economy trade-off in their national approaches towards mitigating the impact of the COVID-19 pandemic.\n\nThis study utilized publicly available COVID-19 data of the Nordic countries from January 2020 to January 3, 2021. COVID-19 epidemiology, public health and health policy, health system capacity, and macroeconomic data were analysed for each Nordic country. Joinpoint regression analysis was performed to identify changes in temporal trends using average monthly percent change (AMPC) and average weekly percent change (AWPC).\n\nSweden's health policy, being by far the most relaxed response to COVID-19, was found to have the largest COVID-19 incidence and mortality, and the highest AWPC increases for both indicators (13.5, 95% CI = 5.6, 22.0, P < 0.001; 6.3, 95% CI = 3.5, 9.1, P < 0.001). Denmark had the highest number of COVID-19 tests per capita, consistent with their approach of increased testing as a preventive strategy for disease transmission. Iceland had the second-highest number of tests per capita due to their mass-testing, contact tracing, quarantine and isolation response. Only Norway had a significant increase in unemployment (AMPC = 2.8%, 95% CI = 0.7-4.9, P < 0.009) while the percentage change in real Gross Domestic Product (GDP) was insignificant for all countries.\n\nThere was no trade-off between public health policy and economy during the COVID-19 pandemic in the Nordic region. Sweden's relaxed and delayed COVID-19 health policy response did not benefit the economy in the short term, while leading to disproportionate COVID-19 hospitalizations and mortality.", "doi": "10.7189/jogh.12.05017", "pmid": "35932219", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-08-11T11:56:37.963Z", "modified": "2022-08-11T11:56:37.976Z"}, {"entity": "publication", "iuid": "686e9094e2a844ee97d3d70c71eba151", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/686e9094e2a844ee97d3d70c71eba151.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/686e9094e2a844ee97d3d70c71eba151"}}, "title": "Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants.", "authors": [{"family": "Monteil", "given": "Vanessa", "initials": "V", "orcid": "0000-0002-2652-5695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8ba8a0b1af6423b9cba0fc4bb3177cd.json"}}, {"family": "Eaton", "given": "Brett", "initials": "B"}, {"family": "Postnikova", "given": "Elena", "initials": "E"}, {"family": "Murphy", "given": "Michael", "initials": "M"}, {"family": "Braunsfeld", "given": "Benedict", "initials": "B", "orcid": "0000-0002-0286-8239", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a74b9e08f1e46638f44e0756d9bc4af.json"}}, {"family": "Crozier", "given": "Ian", "initials": "I"}, {"family": "Kricek", "given": "Franz", "initials": "F"}, {"family": "Niederh\u00f6fer", "given": "Janine", "initials": "J"}, {"family": "Schwarzb\u00f6ck", "given": "Alice", "initials": "A"}, {"family": "Breid", "given": "Helene", "initials": "H"}, {"family": "Devignot", "given": "Stephanie", "initials": "S", "orcid": "0000-0002-0618-5611", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bacda93ff066472489568f9273ace099.json"}}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Kellner", "given": "Max J", "initials": "MJ"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Mereiter", "given": "Stefan", "initials": "S", "orcid": "0000-0002-4832-3090", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1974c14a7be4583a96ceecccbda4f19.json"}}, {"family": "Knapp", "given": "Sylvia", "initials": "S", "orcid": "0000-0001-9016-5244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81c1b98b50754c84b62f7867c9dc453f.json"}}, {"family": "Sanchez Jimenez", "given": "Anna", "initials": "A"}, {"family": "Bugajska-Schretter", "given": "Agnes", "initials": "A", "orcid": "0000-0002-2096-5833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6fcc0fa6cf5d4023834339edd6f743db.json"}}, {"family": "Dohnal", "given": "Alexander", "initials": "A", "orcid": "0000-0002-5844-7329", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9683bf8c8dc47c38bff0cbc9232cd4a.json"}}, {"family": "Ruf", "given": "Christine", "initials": "C"}, {"family": "Gugenberger", "given": "Romana", "initials": "R"}, {"family": "Hagelkruys", "given": "Astrid", "initials": "A", "orcid": "0000-0003-3015-4038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aab27066bf2a4cfbbe675bac0df00156.json"}}, {"family": "Montserrat", "given": "Nuria", "initials": "N", "orcid": "0000-0002-1603-1755", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d4cdae2b5b34dd798f73faa0a3aa391.json"}}, {"family": "Kozieradzki", "given": "Ivona", "initials": "I", "orcid": "0000-0001-8189-3346", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c581959ead34ffe814262e1f18b0216.json"}}, {"family": "Hasan Ali", "given": "Omar", "initials": "O", "orcid": "0000-0001-5185-7520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a12bd2b13624a19be85fd370663a239.json"}}, {"family": "Stadlmann", "given": "Johannes", "initials": "J", "orcid": "0000-0001-5693-6690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab12a13b3ddd442588c1c9bda683d9ee.json"}}, {"family": "Holbrook", "given": "Michael R", "initials": "MR", "orcid": "0000-0002-0824-2667", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fca43f2c8e934b438491b1dbf3fc0e7f.json"}}, {"family": "Schmaljohn", "given": "Connie", "initials": "C"}, {"family": "Oostenbrink", "given": "Chris", "initials": "C", "orcid": "0000-0002-4232-2556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37566a0341cf4fd38366e43218cffd23.json"}}, {"family": "Shoemaker", "given": "Robert H", "initials": "RH", "orcid": "0000-0003-3608-1714", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4892275e3a6b472f9ef6a537a55e3dd8.json"}}, {"family": "Mirazimi", "given": "Ali", "initials": "A", "orcid": "0000-0003-2371-6055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0651be47429c4e5880a13b839d04fe1d.json"}}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G", "orcid": "0000-0001-7035-7038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70afca1611904e419eca43bde2d681be.json"}}, {"family": "Penninger", "given": "Josef M", "initials": "JM", "orcid": "0000-0002-8194-3777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e56aaa008524272bf252df804e06991.json"}}], "type": "journal article", "published": "2022-08-08", "journal": {"title": "EMBO Mol Med", "issn": "1757-4684", "volume": "14", "issue": "8", "pages": "e15230", "issn-l": "1757-4676"}, "abstract": "The recent emergence of multiple SARS-CoV-2 variants has caused considerable concern due to both reduced vaccine efficacy and escape from neutralizing antibody therapeutics. It is, therefore, paramount to develop therapeutic strategies that inhibit all known and future SARS-CoV-2 variants. Here, we report that all SARS-CoV-2 variants analyzed, including variants of concern (VOC) Alpha, Beta, Gamma, Delta, and Omicron, exhibit enhanced binding affinity to clinical grade and phase 2 tested recombinant human soluble ACE2 (APN01). Importantly, soluble ACE2 neutralized infection of VeroE6 cells and human lung epithelial cells by all current VOC strains with markedly enhanced potency when compared to reference SARS-CoV-2 isolates. Effective inhibition of infections with SARS-CoV-2 variants was validated and confirmed in two independent laboratories. These data show that SARS-CoV-2 variants that have emerged around the world, including current VOC and several variants of interest, can be inhibited by soluble ACE2, providing proof of principle of a pan-SARS-CoV-2 therapeutic.", "doi": "10.15252/emmm.202115230", "pmid": "35781796", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9350269"}], "notes": [], "created": "2022-08-15T15:27:01.239Z", "modified": "2022-08-15T15:27:40.940Z"}, {"entity": "publication", "iuid": "a3f700fba1f14d279a1fdcfd5903beac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3f700fba1f14d279a1fdcfd5903beac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3f700fba1f14d279a1fdcfd5903beac"}}, "title": "\"Will it Work as Well on Zoom?\" A Natural Experiment During the Covid-19 Pandemic of Delivering Parenting Groups Via Video Conferencing or in Person.", "authors": [{"family": "van Leuven", "given": "Livia", "initials": "L", "orcid": "0000-0002-2048-8600", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c90a8aae3d841b4808ef39e4db41214.json"}}, {"family": "Lalouni", "given": "Maria", "initials": "M"}, {"family": "Forster", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2022-08-08", "journal": {"title": "J Child Fam Stud", "issn": "1062-1024", "pages": "1-14", "issn-l": null}, "abstract": "While rates of child maltreatment increased during the Covid-19-pandemic, face-to-face interventions to support families got difficult to carry out due to restrictions. Meanwhile, many services do not have access to parenting programs designed for digital or remote delivery. A solution employed by some services was to use video conferencing (VC) to deliver their regular parenting programs. This study examined the effectiveness of the universal group-based parenting program ABC offered through VC instead of on-site meetings during the pandemic. Pre and post measurements were collected from 469 parents participating in either 1) ABC with VC meetings only, 2) on-site meetings only, or 3) blended - a combination of VC and on-site sessions. In addition, 74 group leaders completed a survey about their experiences of VC groups. Analyses showed general improvements in parent practices and child conduct over time, but no differences in effectiveness depending on the format of the parent group (VC, blended, or on-site). Qualitative analyses of group leaders' experiences revealed four key-themes pertaining to both challenges (e.g., concerns about parents' ability to benefit and learn parenting skills) and benefits (e.g., reaching parents who would not have been able to attend physical meetings) of VC groups. Overall, this study showed no significant differences in outcomes between the VC, blended, or on-site format of delivery. There are however limitations of this trial, and results should be considered preliminary. Effectiveness and potential negative consequences of replacing interventions intended to be delivered on-site with VC alternatives need to be further investigated in future trials.", "doi": "10.1007/s10826-022-02398-8", "pmid": "35965634", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "2398"}, {"db": "pmc", "key": "PMC9358366"}], "notes": [], "created": "2022-08-16T15:37:45.172Z", "modified": "2022-08-16T15:37:45.248Z"}, {"entity": "publication", "iuid": "49796efbb57e4d2390a404af3b639dec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49796efbb57e4d2390a404af3b639dec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49796efbb57e4d2390a404af3b639dec"}}, "title": "Subjective well-being among psychotherapists during the coronavirus disease pandemic: A cross-cultural survey from 12 european countries.", "authors": [{"family": "Van Hoy", "given": "Angelika", "initials": "A"}, {"family": "Rzeszutek", "given": "Marcin", "initials": "M"}, {"family": "Pi\u0119ta", "given": "Ma\u0142gorzata", "initials": "M"}, {"family": "Mestre", "given": "Jose M", "initials": "JM"}, {"family": "Rodr\u00edguez-Mora", "given": "\u00c1lvaro", "initials": "\u00c1"}, {"family": "Midgley", "given": "Nick", "initials": "N"}, {"family": "Omylinska-Thurston", "given": "Joanna", "initials": "J"}, {"family": "Dopierala", "given": "Anna", "initials": "A"}, {"family": "Falkenstr\u00f6m", "given": "Fredrik", "initials": "F"}, {"family": "Ferlin", "given": "Jennie", "initials": "J"}, {"family": "Gergov", "given": "Vera", "initials": "V"}, {"family": "Lazi\u0107", "given": "Milica", "initials": "M"}, {"family": "Ulberg", "given": "Randi", "initials": "R"}, {"family": "R\u00f8ssberg", "given": "Jan Ivar", "initials": "JI"}, {"family": "Hancheva", "given": "Camellia", "initials": "C"}, {"family": "Stoyanova", "given": "Stanislava", "initials": "S"}, {"family": "Schmidt", "given": "Stefanie J", "initials": "SJ"}, {"family": "Podina", "given": "Ioana R", "initials": "IR"}, {"family": "Ferreira", "given": "Nuno", "initials": "N"}, {"family": "Kagialis", "given": "Antonios", "initials": "A"}, {"family": "L\u00f6ffler-Stastka", "given": "Henriette", "initials": "H"}, {"family": "Gruszczy\u0144ska", "given": "Ewa", "initials": "E"}], "type": "journal article", "published": "2022-08-07", "journal": {"title": "J Psychiatr Res", "issn": "1879-1379", "volume": "154", "pages": "315-323", "issn-l": null}, "abstract": "The aim of this study is to examine the amount of the total variance of the subjective well-being (SWB) of psychotherapists from 12 European countries explained by between-country vs. between-person differences regarding its cognitive (life satisfaction) and affective components (positive affect [PA] and negative affect [NA]). Second, we explored a link between the SWB and their personal (self-efficacy) and social resources (social support) after controlling for sociodemographics, work characteristics, and COVID-19-related distress.\n\nIn total, 2915 psychotherapists from 12 countries (Austria, Bulgaria, Cyprus, Finland, Great Britain, Serbia, Spain, Norway, Poland, Romania, Sweden, and Switzerland) participated in this study. The participants completed the Satisfaction with Life Scale (SWLS), the International Positive and Negative Affect Schedule Short Form (I-PANAS-SF), the General Self-Efficacy Scale, and the Multidimensional Scale of Perceived Social Support.\n\nCognitive well-being (CWB; satisfaction with life) was a more country-dependent component of SWB than affective well-being (AWB). Consequently, at the individual level, significant correlates were found only for AWB but not for CWB. Higher AWB was linked to being female, older age, higher weekly workload, and lower COVID-19-related distress. Self-efficacy and social support explained AWB only, including their main effects and the moderating effect of self-efficacy.\n\nThe results highlight more individual characteristics of AWB compared to CWB, with a more critical role of low self-efficacy for the link between social support and PA rather than NA. This finding suggests the need for greater self-care among psychotherapists regarding their AWB and the more complex conditions underlying their CWB.", "doi": "10.1016/j.jpsychires.2022.07.065", "pmid": "35994913", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0022-3956(22)00443-5"}, {"db": "pmc", "key": "PMC9357039"}], "notes": [], "created": "2022-09-12T19:01:18.681Z", "modified": "2022-09-12T19:01:29.291Z"}, {"entity": "publication", "iuid": "7b4e92ff01204931bc15070565b2691c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b4e92ff01204931bc15070565b2691c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b4e92ff01204931bc15070565b2691c"}}, "title": "Effectiveness of the BNT162b2 mRNA Vaccine Compared with Hybrid Immunity in Populations Prioritized and Non-Prioritized for COVID-19 Vaccination in 2021-2022: A Naturalistic Case-Control Study in Sweden.", "authors": [{"family": "Spreco", "given": "Armin", "initials": "A", "orcid": "0000-0003-0985-8209", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29a7cab23d784f898e1706bb138caa0f.json"}}, {"family": "Dahlstr\u00f6m", "given": "\u00d6rjan", "initials": "\u00d6", "orcid": "0000-0002-3955-0443", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21ead9243d644fe3a280e7b22d974745.json"}}, {"family": "J\u00f6ud", "given": "Anna", "initials": "A", "orcid": "0000-0001-7192-4911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e038a5ce2f5a47bd89e7c221651a3d24.json"}}, {"family": "Nordvall", "given": "Dennis", "initials": "D"}, {"family": "Fagerstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Blomqvist", "given": "Eva", "initials": "E", "orcid": "0000-0003-0036-6662", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/246bd5fbd6e7428b82a39e69e5ad7491.json"}}, {"family": "Gustafsson", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-3270-171X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a43a8fb037c340d5bd85b81fcabc69d5.json"}}, {"family": "Hinkula", "given": "Jorma", "initials": "J", "orcid": "0000-0003-1908-5609", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c5c582ce23e4e608680e31197be2fc7.json"}}, {"family": "Sch\u00f6n", "given": "Thomas", "initials": "T"}, {"family": "Timpka", "given": "Toomas", "initials": "T", "orcid": "0000-0001-6049-5402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebcb4fac20f845a4bd9eaa4bf1660ebb.json"}}], "type": "journal article", "published": "2022-08-07", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "8", "pages": "1273", "issn-l": null}, "abstract": "The term hybrid immunity is used to denote the immunological status of vaccinated individuals with a history of natural infection. Reports of new SARS-CoV-2 variants of concern motivate continuous rethought and renewal of COVID-19 vaccination programs. We used a naturalistic case-control study design to compare the effectiveness of the BNT162b2 mRNA vaccine to hybrid immunity 180 days post-vaccination in prioritized and non-prioritized populations vaccinated before 31 July 2021 in three Swedish counties (total population 1,760,000). Subjects with a positive SARS-CoV-2 test recorded within 6 months before vaccination (n = 36,247; 6%) were matched to vaccinated-only controls. In the prioritized population exposed to the SARS-CoV-2 Alpha and Delta variants post-vaccination, the odds ratio (OR) for breakthrough infection was 2.2 (95% CI, 1.6\u22122.8; p < 0.001) in the vaccinated-only group compared with the hybrid immunity group, while in the later vaccinated non-prioritized population, the OR decreased from 4.3 (95% CI, 2.2\u22128.6; p < 0.001) during circulation of the Delta variant to 1.9 (95% CI, 1.7\u22122.1; p < 0.001) with the introduction of the Omicron variant (B.1.617.2). We conclude that hybrid immunity provides gains in protection, but that the benefits are smaller for risk groups and with circulation of the Omicron variant and its sublineages.", "doi": "10.3390/vaccines10081273", "pmid": "36016162", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9414381"}, {"db": "pii", "key": "vaccines10081273"}], "notes": [], "created": "2022-09-12T19:12:01.791Z", "modified": "2023-06-19T14:58:56.409Z"}, {"entity": "publication", "iuid": "13e363574aaa4eb0944287a36d5f46e9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13e363574aaa4eb0944287a36d5f46e9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13e363574aaa4eb0944287a36d5f46e9"}}, "title": "Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection.", "authors": [{"family": "Barturen", "given": "Guillermo", "initials": "G", "orcid": "0000-0003-2103-1028", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a338918e305480497c4e51b5874dd52.json"}}, {"family": "Carnero-Montoro", "given": "Elena", "initials": "E"}, {"family": "Mart\u00ednez-Bueno", "given": "Manuel", "initials": "M"}, {"family": "Rojo-Rello", "given": "Silvia", "initials": "S"}, {"family": "Sobrino", "given": "Beatriz", "initials": "B"}, {"family": "Porras-Perales", "given": "\u00d3scar", "initials": "\u00d3", "orcid": "0000-0001-7164-6616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8668d9ae7124937bad9b03d231447f3.json"}}, {"family": "Alc\u00e1ntara-Dom\u00ednguez", "given": "Clara", "initials": "C", "orcid": "0000-0002-4925-4955", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7cbf4f6c8e3f4bfea012bc2bcaf46a54.json"}}, {"family": "Bernardo", "given": "David", "initials": "D"}, {"family": "Alarc\u00f3n-Riquelme", "given": "Marta E", "initials": "ME", "orcid": "0000-0002-7632-4154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f74dd701d8442c992fe172be2d2c5bf.json"}}], "type": "journal article", "published": "2022-08-06", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "13", "issue": "1", "pages": "4597"}, "abstract": "SARS-CoV-2 infection can cause an inflammatory syndrome (COVID-19) leading, in many cases, to bilateral pneumonia, severe dyspnea, and in ~5% of these, death. DNA methylation is known to play an important role in the regulation of the immune processes behind COVID-19 progression, however it has not been studied in depth. In this study, we aim to evaluate the implication of DNA methylation in COVID-19 progression by means of a genome-wide DNA methylation analysis combined with DNA genotyping. The results reveal the existence of epigenomic regulation of functional pathways associated with COVID-19 progression and mediated by genetic loci. We find an environmental trait-related signature that discriminates mild from severe cases and regulates, among other cytokines, IL-6 expression via the transcription factor CEBP. The analyses suggest that an interaction between environmental contribution, genetics, and epigenetics might be playing a role in triggering the cytokine storm described in the most severe cases.", "doi": "10.1038/s41467-022-32357-2", "pmid": "35933486", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-022-32357-2"}, {"db": "pmc", "key": "PMC9357033"}], "notes": [], "created": "2022-08-11T11:55:38.059Z", "modified": "2022-11-18T09:52:20.620Z"}, {"entity": "publication", "iuid": "d9711d4c6520454ca075454488bedb44", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d9711d4c6520454ca075454488bedb44.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d9711d4c6520454ca075454488bedb44"}}, "title": "The Perception of the Patient Safety Climate by Health Professionals during the COVID-19 Pandemic-International Research.", "authors": [{"family": "Kosydar-Bochenek", "given": "Justyna", "initials": "J", "orcid": "0000-0003-1028-2286", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6d99072901c46bb9eadd702b89537e7.json"}}, {"family": "Krupa", "given": "Sabina", "initials": "S", "orcid": "0000-0002-3002-3153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/479d63dc95544c2ba3439438fc553192.json"}}, {"family": "Religa", "given": "Dorota", "initials": "D"}, {"family": "Friganovi\u0107", "given": "Adriano", "initials": "A", "orcid": "0000-0002-9528-6464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f01bf1aaf114c6fa7822f3dcb1d4dac.json"}}, {"family": "Oomen", "given": "Ber", "initials": "B"}, {"family": "Brioni", "given": "Elena", "initials": "E"}, {"family": "Iordanou", "given": "Stelios", "initials": "S", "orcid": "0000-0001-7618-0915", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc269f1e185e4d69a880ec7f875ff983.json"}}, {"family": "Suchoparski", "given": "Marcin", "initials": "M"}, {"family": "Knap", "given": "Ma\u0142gorzata", "initials": "M", "orcid": "0000-0003-0425-7631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d232bb7ac80463e9b4199b6a841f05a.json"}}, {"family": "M\u0119drzycka-D\u0105browska", "given": "Wioletta", "initials": "W", "orcid": "0000-0001-8377-4893", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ff04cc1fa0b4a7ba15bcdbdb287fda2.json"}}], "type": "journal article", "published": "2022-08-06", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "15", "issn-l": null}, "abstract": "The patient safety climate is a key element of quality in healthcare. It should be a priority in the healthcare systems of all countries in the world. The goal of patient safety programs is to prevent errors and reduce the potential harm to patients when using healthcare services. A safety climate is also necessary to ensure a safe working environment for healthcare professionals. The attitudes of healthcare workers toward patient safety in various aspects of work, organization and functioning of the ward are important elements of the organization's safety culture. The aim of this study was to determine the perception of the patient safety climate by healthcare workers during the COVID-19 pandemic.\n\nThe study was conducted in five European countries. The Safety Attitude Questionnaire (SAQ) short version was used for the study. A total of 1061 healthcare workers: physicians, nurses and paramedics, participated in this study.\n\nAll groups received the highest mean results on the stress recognition subscale (SR): nurses 98.77, paramedics 96.39 and physician 98.28. Nurses and physicians evaluated work conditions (WC) to be the lowest (47.19 and 44.99), while paramedics evaluated perceptions of management (PM) as the worst (46.44). Paramedics achieved statistically significantly lower scores compared to nurses and physicians in job satisfaction (JS), stress recognition (SR) and perception of management (PM) (p &lt; 0.0001). Paramedics compared to nurses and physicians rank better in working conditions (WC) in relation to patient safety (16.21%). Most often, persons of lower seniority scored higher in all subscales (p = 0.001). In Poland, Spain, France, Turkey, and Greece, healthcare workers scored highest in stress recognition (SR). In Poland, Spain, France, and Turkey, they assessed working conditions (WC) as the worst, while in Greece, the perception of management (PM) had the lowest result.\n\nParticipant perceptions about the patient safety climate were not at a particularly satisfactory level, and there is still a need for the development of patient safety culture in healthcare in Europe. Overall, positive working conditions, good management and effective teamwork can contribute to improving employees' attitudes toward patient safety. This study was carried out during the COVID-19 pandemic and should be repeated after its completion, and comparative studies will allow for a more precise determination of the safety climate in the assessment of employees.", "doi": "10.3390/ijerph19159712", "pmid": "35955067", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19159712"}, {"db": "pmc", "key": "PMC9368342"}], "notes": [], "created": "2022-08-16T15:42:44.739Z", "modified": "2022-08-16T15:42:44.963Z"}, {"entity": "publication", "iuid": "3bd9fe0e284e490b8a2809518c07b50f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3bd9fe0e284e490b8a2809518c07b50f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3bd9fe0e284e490b8a2809518c07b50f"}}, "title": "Binge-Watching and Mental Health Problems: A Systematic Review and Meta-Analysis.", "authors": [{"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Jafari", "given": "Elahe", "initials": "E", "orcid": "0000-0003-2553-8192", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2aee5b18f3b1425c85985e630c206bea.json"}}, {"family": "Potenza", "given": "Marc N", "initials": "MN", "orcid": "0000-0002-6323-1354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b6ecc2df9444fe0bd86487afa9bb58b.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Wu", "given": "Chien-Yi", "initials": "CY", "orcid": "0000-0003-0585-0293", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d56dd8eb9a114f8eb641ae5ca4764e08.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2022-08-06", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "15", "issn-l": null}, "abstract": "Binge-watching, the viewing of online videos or streamed content, may be associated with different types of mental health problems. The present study aimed to investigate the associations between binge-watching and five mental health concerns including depression, loneliness, sleep problems, anxiety, and stress.\n\nAcademic databases of PubMed, Scopus, Web of Science, ProQuest, PsycINFO, and Psych Articles were systematically searched through February of 2022. The Newcastle-Ottawa Scale was used to assess the methodological quality. A meta-analysis was performed on Fisher's z values as effect sizes, using a random effect model. Publication bias, small study effect, and moderators in this association were assessed.\n\nBinge-watching was significantly associated with the five types of mental health concerns with the most robust correlations found with stress (0.32) and anxiety (0.25). Stronger associations between binge-watching and two types of mental health problems (depression and sleep problems) were found during the COVID-19 pandemic than before the pandemic. Moreover, stronger associations between binge-watching and two types of mental health problems (stress and sleep problems) were found in developing countries than in developed countries.\n\nThe associations between binge-watching and mental health concerns were significant and positive. Programs and interventions to reduce binge-watching should be considered and tested.", "doi": "10.3390/ijerph19159707", "pmid": "35955069", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijerph19159707"}, {"db": "pmc", "key": "PMC9368441"}], "notes": [], "created": "2022-08-16T15:42:24.334Z", "modified": "2022-08-16T15:42:24.494Z"}, {"entity": "publication", "iuid": "e899b38a906b49f8a2b14ddd344b04a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e899b38a906b49f8a2b14ddd344b04a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e899b38a906b49f8a2b14ddd344b04a0"}}, "title": "A pilot clinical and radiographic study on the association between periodontitis and serious COVID-19 infection.", "authors": [{"family": "Gardelis", "given": "Panagiotis", "initials": "P"}, {"family": "Zekeridou", "given": "Alkisti", "initials": "A", "orcid": "0000-0001-9468-8958", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe50bb3ddfba4f0a89c53f18025abce1.json"}}, {"family": "Suh", "given": "Noemie", "initials": "N"}, {"family": "Le Terrier", "given": "Christophe", "initials": "C"}, {"family": "Stavropoulos", "given": "Andreas", "initials": "A", "orcid": "0000-0001-8161-3754", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c54209640baf41f4bc60dcec6174e241.json"}}, {"family": "Giannopoulou", "given": "Catherine", "initials": "C"}], "type": "journal article", "published": "2022-08-06", "journal": {"title": "Clin Exp Dent Res", "issn": "2057-4347", "issn-l": null}, "abstract": "During the pandemic of COVID-19, the scientific community tried to identify the risk factors that aggravate the viral infection. Oral health and specifically periodontitis have been shown to have a significant impact on overall health. Current, yet limited, evidence suggests a link between periodontal status and severity of COVID-19 infection.\n\nThe present pilot study aimed to assess whether younger patients (\u226460 years) that have been hospitalized in the intensive care unit (ICU) for severe COVID-19 infection were susceptible to severe periodontitis.\n\nAll dentate patients \u226460 years of age diagnosed with COVID-19 and surviving hospitalization in the ICU were considered for inclusion. Susceptibility to periodontitis was determined by assessing radiographic bone loss (RBL) in recent dental radiographs (posterior bitewings, periapical, and panoramic X-rays). RBL in % was obtained from the most affected tooth and patients were classified into: Stage I, RBL \u2264 15%; Stage II, RBL = 15%-33% and Stage III/IV, RBL \u2265 33%. The grade was defined using the RBL to age ratio on the most severely affected tooth. Patients were attributed to: Grade A, ratio <0.25; Grade B, ratio 0.25-1 and Grade C, ratio >1. Patients classified into Stage III/IV and Grade C were considered highly susceptible to periodontitis.\n\nOf 87 eligible patients, 30 patients were finally assessed radiographically and/or clinically; from the remaining 57 patients, 16 refused participation for various reasons and 41 could not be reached. Based on the radiographic assessment, all patients were periodontally compromised. Half of them were classified with Stage III/IV and Grade B or C; 26.7% were classified with Stage III/IV and Grade C.\n\nThe present pilot study showed that about half of the patients suffering from severe forms of COVID-19 infection in need of ICU admission suffered also from severe periodontitis, and about one-fourth of them were highly susceptible to it.", "doi": "10.1002/cre2.610", "pmid": "35932180", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-11T11:56:56.240Z", "modified": "2022-08-11T11:56:56.345Z"}, {"entity": "publication", "iuid": "aee729d636e1464e89c86ae436a9c572", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aee729d636e1464e89c86ae436a9c572.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aee729d636e1464e89c86ae436a9c572"}}, "title": "Vaccination nudges: A study of pre-booked COVID-19 vaccinations in Sweden.", "authors": [{"family": "Bonander", "given": "Carl", "initials": "C"}, {"family": "Ekman", "given": "Mats", "initials": "M"}, {"family": "Jakobsson", "given": "Niklas", "initials": "N"}], "type": "journal article", "published": "2022-08-05", "journal": {"title": "Soc Sci Med", "issn": "1873-5347", "volume": "309", "pages": "115248", "issn-l": null}, "abstract": "A nudge changes people's actions without removing their options or altering their incentives. During the COVID-19 vaccine rollout, the Swedish Region of Uppsala sent letters with pre-booked appointments to inhabitants aged 16-17 instead of opening up manual appointment booking. Using regional and municipal vaccination data, we document a higher vaccine uptake among 16- to 17-year-olds in Uppsala compared to untreated control regions (constructed using the synthetic control method as well as neighboring municipalities). The results highlight pre-booked appointments as a strategy for increasing vaccination rates in populations with low perceived risk.", "doi": "10.1016/j.socscimed.2022.115248", "pmid": "35969977", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0277-9536(22)00554-8"}, {"db": "pmc", "key": "PMC9354447"}], "notes": [], "created": "2022-08-16T15:37:03.576Z", "modified": "2022-08-19T05:26:49.553Z"}, {"entity": "publication", "iuid": "9a3667b343c94f65adf60d2de6216896", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9a3667b343c94f65adf60d2de6216896.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9a3667b343c94f65adf60d2de6216896"}}, "title": "Risk factors for anxiety and depression among pregnant women during COVID-19 pandemic - results of a web-based multinational cross-sectional study.", "authors": [{"family": "Kajdy", "given": "Anna", "initials": "A"}, {"family": "Sys", "given": "Dorota", "initials": "D"}, {"family": "Pokropek", "given": "Artur", "initials": "A"}, {"family": "Shaw", "given": "Steven W", "initials": "SW"}, {"family": "Chang", "given": "Tung-Yao", "initials": "TY"}, {"family": "Calda", "given": "Pavel", "initials": "P"}, {"family": "Acharya", "given": "Ganesh", "initials": "G"}, {"family": "Ben-Zion", "given": "Maya", "initials": "M"}, {"family": "Biron-Shental", "given": "Tal", "initials": "T"}, {"family": "Borowski", "given": "Dariusz", "initials": "D"}, {"family": "Czuba", "given": "Bartosz", "initials": "B"}, {"family": "Etchegaray", "given": "Adolfo", "initials": "A"}, {"family": "Feduniw", "given": "Stepan", "initials": "S"}, {"family": "Garcia-Mandujano", "given": "Rosario", "initials": "R"}, {"family": "Garcia Santacruz", "given": "Monica", "initials": "M"}, {"family": "Gil", "given": "Maria M", "initials": "MM"}, {"family": "Hassan", "given": "Sonia", "initials": "S"}, {"family": "Kwiatkowski", "given": "Sebastian", "initials": "S"}, {"family": "Martin-Arias", "given": "Arancha", "initials": "A"}, {"family": "Martinez-Portilla", "given": "Raigam Jafet", "initials": "RJ"}, {"family": "Prefumo", "given": "Federico", "initials": "F"}, {"family": "Rabijewski", "given": "Micha\u0142", "initials": "M"}, {"family": "Salomon", "given": "Laurent J", "initials": "LJ"}, {"family": "Tiller", "given": "Heidi", "initials": "H"}, {"family": "Verlohren", "given": "Stefan", "initials": "S"}, {"family": "Voon", "given": "Hian Yan", "initials": "HY"}, {"family": "Fernando Yanque-Robles", "given": "Omar", "initials": "O"}, {"family": "Yong", "given": "Soon Leong", "initials": "SL"}, {"family": "Poon", "given": "Liona C", "initials": "LC"}, {"family": "Mind-COVID Collaborative Team", "given": "", "initials": ""}], "type": "journal article", "published": "2022-08-05", "journal": {"title": "Int J Gynaecol Obstet", "issn": "1879-3479", "issn-l": null}, "abstract": "Mind-COVID is a prospective cross-sectional study aimed to assess risk factors for anxiety and depression among pregnant women during the COVID-19 pandemic. This study compares outcomes in middle-income economies and high-income economies.\n\n7,102 pregnant women from 12 high-income economies and 9 middle-income economies were included. The web-based survey used two standardised instruments, GAD-7 and PHQ-9.\n\nPregnant women in high-income economies reported higher PHQ-9 (0.18 SD, p<<0.001) and GAD-7 (0.08 SD, p=0.005) scores than those living in middle-income economies. Multivariate regression analysis showed that increasing PHQ-9 and GAD-7 scales were associated with mental health problems during pregnancy and the need of psychiatric treatment before pregnancy. PHQ-9 was associated with feeling of burden related to restrictions in social distancing and access to leisure activities. GAD-7 scores were associated with a pregnancy-related complication, fear of adverse outcomes in children related to COVID-19 and feeling of burden related to finances.\n\nAccording to this study, the imposed public health measures and hospital restrictions have left pregnant women more vulnerable during these difficult times. Adequate partner and family support during pregnancy and childbirth can be one of the most important protective factors against anxiety and depression, regardless of national economic status.", "doi": "10.1002/ijgo.14388", "pmid": "35932096", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-11T11:57:19.817Z", "modified": "2022-08-11T11:57:19.852Z"}, {"entity": "publication", "iuid": "3a7132762a8a493a89cfdd6c056d3dce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a7132762a8a493a89cfdd6c056d3dce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a7132762a8a493a89cfdd6c056d3dce"}}, "title": "Challenges imposed by the COVID-19 pandemic on the Obstetrics and Gynecology residency program: a mixed-methods Swedish survey in the COPE Staff cohort study.", "authors": [{"family": "W\u00e5dell", "given": "Matilda", "initials": "M"}, {"family": "\u00d6rtqvist", "given": "Anne K", "initials": "AK"}, {"family": "Linden", "given": "Karolina", "initials": "K"}, {"family": "Akerstrom", "given": "Magnus", "initials": "M"}, {"family": "Andersson", "given": "Ola", "initials": "O"}, {"family": "Carlsson", "given": "Ylva", "initials": "Y"}, {"family": "Graner", "given": "Sofie", "initials": "S"}, {"family": "Jonsson", "given": "Maria", "initials": "M"}, {"family": "Naurin", "given": "Elin", "initials": "E"}, {"family": "Sengpiel", "given": "Verena", "initials": "V"}, {"family": "Veje", "given": "Malin", "initials": "M"}, {"family": "Wessberg", "given": "Anna", "initials": "A"}, {"family": "Zaigham", "given": "Mehreen", "initials": "M"}], "type": "journal article", "published": "2022-08-05", "journal": {"title": "BMC Med Educ", "issn": "1472-6920", "volume": "22", "issue": "1", "pages": "602", "issn-l": null}, "abstract": "To outline how the training program and work situation of residents in Obstetrics and Gynecology (OB-GYN) was affected by the pandemic and to illuminate how residents experienced these changes.\n\nAs part of the COVID-19 in Pregnancy and Early Childhood Staff (COPE Staff) cohort study, between January and May 2021, all participating residents were invited to answer a 28-question online Resident Survey focusing on their specialist education, work situation and experiences during the COVID-19 pandemic. Descriptive statistics were given in percentages for categorical variables and means and standard deviations (SD) for continuous variables. Univariate comparative analyses were performed with the use of the Pearson's Chi-2-test for dichotomous data. The association between residents' worry about the quality and length of their specialist training, with extra clinical hours and transfer to other healthcare institutions were assessed by multivariate logistic regression. Free text responses were analyzed by content analysis.\n\nOf the 162 participating OB-GYN residents, 69% expressed concern that the pandemic would have a negative impact on their training. Ninety-five (95%) reported cancellation/postponement of educational activities, 70% performed fewer surgeries and 27% had been transferred to other healthcare institutions where about half reported having gained more general knowledge as a physician. Working extra clinical hours was reported by 69% (7.4 \u00b1 5.3 hours per week) and 14% had considered changing their profession due to the pandemic. Senior residents, compared to junior residents, more often experienced cancelled/postponed clinical rotations (30% vs 15%, P=0.02) and reported performing fewer surgeries (P=0.02). The qualitative analysis highlighted the lack of surgical procedural training as a major concern for residents.\n\nThe COVID-19 pandemic has strongly impacted the training program and work situation of OB-GYN residents in Sweden. Residents were concerned over the negative impact of the pandemic on their training program and senior residents reported more missed educational opportunities as compared to junior residents. Program directors, head of institutions and clinical supervisors can use the problem areas pinpointed by this study to support residents and compensate for missed educational opportunities. While hands-on-training and operating time cannot be compensated for, the authors hope that the findings of the study can help develop new strategies to minimize the negative impact of the current and future pandemics on resident education and work situation.", "doi": "10.1186/s12909-022-03631-0", "pmid": "35927725", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12909-022-03631-0"}, {"db": "pmc", "key": "PMC9354310"}], "notes": [], "created": "2022-08-11T12:00:24.793Z", "modified": "2022-08-11T12:00:24.806Z"}, {"entity": "publication", "iuid": "76979789107a4e098eaecbc23e9e6f00", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76979789107a4e098eaecbc23e9e6f00.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76979789107a4e098eaecbc23e9e6f00"}}, "title": "COVID-19 vaccination in pregnant women in Sweden and Norway.", "authors": [{"family": "\u00d6rtqvist", "given": "Anne K", "initials": "AK"}, {"family": "Dahlqwist", "given": "Elisabeth", "initials": "E"}, {"family": "Magnus", "given": "Maria C", "initials": "MC"}, {"family": "Ljung", "given": "Rickard", "initials": "R"}, {"family": "Jonsson", "given": "Jerker", "initials": "J"}, {"family": "Aronsson", "given": "Bernice", "initials": "B"}, {"family": "Pasternak", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}], "type": "journal article", "published": "2022-08-05", "journal": {"title": "Vaccine", "issn": "1873-2518", "volume": "40", "issue": "33", "pages": "4686-4692", "issn-l": null}, "abstract": "Vaccines against SARS-CoV-2 are highly effective in preventing severe disease and mortality. Although pregnant women are at increased risk of severe COVID-19, vaccination uptake among pregnant women varies. We used the Swedish and Norwegian population-based health registries to identify pregnant women and to investigate background characteristics associated with not being vaccinated. In this study of 164 560 women giving birth between May 2021 and May 2022, 78% in Sweden and 87% in Norway have been vaccinated with at least one dose at delivery. Not being vaccinated while being pregnant was associated with age below 30 years, low education and income level, birth region other than Scandinavia, smoking during pregnancy, not living with a partner, and gestational diabetes. These results can assist health authorities develop targeted vaccination information to diminish vaccination inequality and prevent severe disease in vulnerable groups.", "doi": "10.1016/j.vaccine.2022.06.083", "pmid": "35842337", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Vaccines": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9273610"}, {"db": "pii", "key": "S0264-410X(22)00859-3"}], "notes": [], "created": "2022-08-12T08:54:24.048Z", "modified": "2023-07-13T11:30:28.895Z"}, {"entity": "publication", "iuid": "e0144e1b48894804a2c8a78d0f70a85b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e0144e1b48894804a2c8a78d0f70a85b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e0144e1b48894804a2c8a78d0f70a85b"}}, "title": "South African University Staff and Students' Perspectives, Preferences, and Drivers of Hesitancy Regarding COVID-19 Vaccines: A Multi-Methods Study.", "authors": [{"family": "George", "given": "Gavin", "initials": "G", "orcid": "0000-0001-7258-8470", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1047f3615ff7472ca7153120996b5a3d.json"}}, {"family": "Strauss", "given": "Michael", "initials": "M", "orcid": "0000-0001-7849-8812", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2460c075273474ca7b13a37b7c309ae.json"}}, {"family": "Lansdell", "given": "Emma", "initials": "E"}, {"family": "Nadesan-Reddy", "given": "Nisha", "initials": "N"}, {"family": "Moroe", "given": "Nomfundo", "initials": "N", "orcid": "0000-0001-7186-5632", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7fc9e62155c4629b1dfb65c3fc49876.json"}}, {"family": "Reddy", "given": "Tarylee", "initials": "T"}, {"family": "Eshun-Wilsonova", "given": "Ingrid", "initials": "I"}, {"family": "Moshabela", "given": "Mosa", "initials": "M"}], "type": "journal article", "published": "2022-08-04", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "COVID-19 vaccine hesitancy poses a threat to the success of vaccination programmes currently being implemented. Concerns regarding vaccine effectiveness and vaccine-related adverse events are potential barriers to vaccination; however, it remains unclear whether tailored messaging and vaccination programmes can influence uptake. Understanding the preferences of key groups, including students, could guide the implementation of youth-targeted COVID-19 vaccination programmes, ensuring optimal uptake. This study examined university staff and students' perspectives, preferences, and drivers of hesitancy regarding COVID-19 vaccines. A multi-methods approach was used-an online convenience sample survey and discrete choice experiment (DCE)-targeting staff and students at the University of KwaZulu-Natal, South Africa. The survey and DCE were available for staff and students, and data were collected from 18 November to 24 December 2021. The survey captured demographic characteristics as well as attitudes and perspectives of COVID-19 and available vaccines using modified Likert rating questions adapted from previously used tools. The DCE was embedded within the survey tool and varied critical COVID-19 vaccine programme characteristics to calculate relative utilities (preferences) and determine trade-offs. A total of 1836 staff and students participated in the study (541 staff, 1262 students, 33 undisclosed). A total of 1145 (62%) respondents reported that they had been vaccinated against COVID-19. Vaccination against COVID-19 was less prevalent among students compared with staff (79% of staff vs. 57% of students). The vaccine's effectiveness (22%), and its safety (21%), ranked as the two dominant reasons for not getting vaccinated. These concerns were also evident from the DCE, with staff and students being significantly influenced by vaccine effectiveness, with participants preferring highly effective vaccines (90% effective) as compared with those listed as being 70% or 50% effective (\u03b2 = -3.72, 95% CI = -4.39 to -3.04); this characteristic had the strongest effect on preferences of any attribute. The frequency of vaccination doses was also found to have a significant effect on preferences with participants deriving less utility from choice alternatives requiring two initial vaccine doses compared with one dose (\u03b2 = -1.00, 95% CI = -1.42 to -0.58) or annual boosters compared with none (\u03b2 = -2.35, 95% CI = -2.85 to -1.86). Notably, an incentive of ZAR 350 (USD 23.28) did have a positive utility (\u03b2 = 1.14, 95% CI = 0.76 to 1.53) as compared with no incentive. Given the slow take-up of vaccination among youth in South Africa, this study offers valuable insights into the factors that drive hesitancy among this population. Concerns have been raised around the safety and effectiveness of vaccines, although there remains a predilection for efficient services. Respondents were not enthusiastic about the prospect of having to take boosters, and this has played out in the roll-out data. Financial incentives may increase both the uptake of the initial dose of vaccines and see a more favourable response to subsequent boosters. Universities should consider tailored messaging regarding vaccine effectiveness and facilitate access to vaccines, to align services with the stated preferences of staff and students.", "doi": "10.3390/vaccines10081250", "pmid": "36016138", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "vaccines10081250"}, {"db": "pmc", "key": "PMC9412872"}], "notes": [], "created": "2022-09-12T19:11:37.572Z", "modified": "2022-09-12T19:11:37.697Z"}, {"entity": "publication", "iuid": "f1d0a53cf20a4652a557b646d63a1bfb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1d0a53cf20a4652a557b646d63a1bfb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1d0a53cf20a4652a557b646d63a1bfb"}}, "title": "Impaired physical function in patients with idiopathic inflammatory myopathies: results from the multicentre COVAD patient-reported e-survey.", "authors": [{"family": "Yoshida", "given": "Akira", "initials": "A", "orcid": "0000-0003-3590-1637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e26dfbeb7e8486a8492abc2700590df.json"}}, {"family": "Kim", "given": "Minchul", "initials": "M", "orcid": "0000-0001-9737-6255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd2952c6167b4733bfbce019a162b310.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Naveen", "given": "R", "initials": "R", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-0986-8354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2e6226ae5e7427fbf52e180dd14e28f.json"}}, {"family": "Kardes", "given": "Sinan", "initials": "S", "orcid": "0000-0002-6311-8634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2900c3ca00da476a8914574384a3c9c2.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Edgar Gracia-Ramos", "given": "Abraham", "initials": "A", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "O'Callaghan", "given": "Albert Selva", "initials": "AS", "orcid": "0000-0003-2823-9761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef3e202c049b44a2a5e045bac90a393a.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "COVAD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-08-03", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "issn-l": null}, "abstract": "The assessment of physical function is fundamental in the management of patients with idiopathic inflammatory myopathies (IIMs). We aimed to investigate the physical function of patients with IIMs compared with those with non-IIM autoimmune rheumatic diseases (AIRDs) utilizing Patient-Reported Outcome Measurement Information System (PROMIS) Physical Function (PF) data obtained in the COVAD study, an international self-reported e-survey assessing the safety of COVID-19 vaccines in AIRDs.\n\nDemographics, AIRD diagnosis, disease activity, and PROMIS PF short form-10a data were extracted from the COVAD database. PROMIS PF-10a scores were compared between disease categories and stratified by disease activity. Factors affecting PROMIS PF-10a scores other than disease activity were identified by multivariable regression analysis in patients with inactive disease.\n\n1057 IIM patients, 3635 non-IIM AIRD patients, and 3981 healthy controls (HCs) responded to the COVAD e-survey from April to August 2021. Using a binomial regression model, the predicted mean of PROMIS PF-10a scores was significantly lower in IIM patients compared with non-IIM AIRD patients or HCs (36.3 [95% confidence interval (CI) 35.5-37.1] vs 41.3 [95%CI 40.2-42.5] vs 46.2 [95%CI 45.8-46.6], P < 0.001), irrespective of disease activity. The independent factors for lower PROMIS PF-10a scores in patients with inactive disease were older age, female, longer disease duration, and a diagnosis of inclusion body myositis or polymyositis.\n\nPhysical function is significantly impaired in IIMs compared with non-IIM AIRDs or HCs, even in patients with inactive disease. Our study highlights a critical need for better strategies to minimize functional disability in patients with IIMs.", "doi": "10.1093/rheumatology/keac441", "pmid": "35920795", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6654606"}], "notes": [], "created": "2022-08-11T12:01:35.086Z", "modified": "2022-08-11T12:01:35.444Z"}, {"entity": "publication", "iuid": "8e6e2fe558dd4111892768da43c2a8f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e6e2fe558dd4111892768da43c2a8f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e6e2fe558dd4111892768da43c2a8f9"}}, "title": "Pre-pandemic Alzheimer Disease Biomarkers and Anxious-Depressive Symptoms During the COVID-19 Confinement in Cognitively Unimpaired Adults.", "authors": [{"family": "Akinci", "given": "Muge", "initials": "M"}, {"family": "Pe\u00f1a-G\u00f3mez", "given": "Cleof\u00e9", "initials": "C"}, {"family": "Operto", "given": "Gregory", "initials": "G"}, {"family": "Fuentes-Julian", "given": "Sherezade", "initials": "S"}, {"family": "Deulofeu", "given": "Carme", "initials": "C"}, {"family": "S\u00e1nchez-Benavides", "given": "Gonzalo", "initials": "G"}, {"family": "Mil\u00e0-Alom\u00e0", "given": "Marta", "initials": "M"}, {"family": "Grau-Rivera", "given": "Oriol", "initials": "O"}, {"family": "Gramunt", "given": "Nina", "initials": "N"}, {"family": "Navarro", "given": "Arcadi", "initials": "A"}, {"family": "Minguill\u00f3n", "given": "Carolina", "initials": "C"}, {"family": "Fauria", "given": "Karine", "initials": "K"}, {"family": "Suridjan", "given": "Ivonne", "initials": "I"}, {"family": "Kollmorgen", "given": "Gwendlyn", "initials": "G"}, {"family": "Bayfield", "given": "Anna", "initials": "A"}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/351fab09f6e24b9f9e6695da83947cb6.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0002-4671-6763", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79e95c490f72402196c43d602ce8e708.json"}}, {"family": "Molinuevo", "given": "Jos\u00e9 Luis", "initials": "JL"}, {"family": "Su\u00e1rez-Calvet", "given": "Marc", "initials": "M"}, {"family": "Gispert", "given": "Juan Domingo", "initials": "JD", "orcid": "0000-0002-6155-0642", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a88d83a5ca4c4a9ea428fcb3f339ca34.json"}}, {"family": "Arenaza-Urquijo", "given": "Eider M", "initials": "EM"}], "type": "journal article", "published": "2022-08-02", "journal": {"title": "Neurology", "issn": "1526-632X", "issn-l": "0028-3878"}, "abstract": "Increased anxious-depressive symptomatology is observed in the preclinical stage of Alzheimer's disease (AD), which may accelerate disease progression. We investigated whether amyloid-\u03b2, , neuroinflammation and sociodemographic factors were associated with cortical thickness in medial temporal lobe structures anxious-depressive symptoms during the COVID-19 confinement.greater\n\nThis retrospective observational study included cognitively unimpaired older adults from the ALFA (Alzheimer and FAmilies) cohort, the majority with a family history of sporadic AD. Participants performed the Hospital Anxiety and Depression Scale (HADS) during the COVID-19 confinement. A subset had available retrospective (on average: 2.4 years before) HADS assessment, amyloid [18F] flutemetamol PET and structural MRI scans and CSF markers of neuroinflammation (interleukin-6 [IL-6], triggering receptor expressed on myeloid cells 2 and glial fibrillary acidic protein levels). We performed multivariable regression models to investigate the associations of linear biomarkers and sociodemographic factors with HADS scores during the confinementpre-pandemic AD-related. . Finally, we explored the role of stress and lifestyle changes (sleep patterns, eating, drinking, smoking habits, and medication use) on the tested associations and performed sex-stratified analyses.We further performed an analysis of covariance in order to adjust by participants' pre-pandemic anxiety-depression levels\n\nWe included 921 (254 with AD biomarkers) participants. Amyloid-\u03b2 positivity (B=3.73; 95%CI=1.1 to 6.36; p=.006), caregiving (B=1.37; 95%CI=0.24 to 2.5; p=.018), sex (women: B=1.95; 95%CI=1.1 to 2.79; p<.001), younger age (B=-0.12; 95%CI=-0.18 to -0.052; p<.001) and lower education (B=-0.16; 95%CI=-0.28 to -0.042; p=.008) were associated with greater anxious-depressive symptoms during the confinement. Considering pre-pandemic anxiety-depression levels, we further observed an association between (B=-5.11; 95%CI=-10.1 to -0.13; lower levels of CSF IL-6p=.044) and HADS scores. The results were independent of stress-related variables and lifestyle changes. Stratified analysis revealed that the associations were mainly driven by women.greater\n\nOur results link AD-related pathophysiology and neuroinflammation with anxious-depressive symptomatology during the COVID-19-related confinement, notably in women. AD pathophysiology may increase neuropsychiatric symptomatology in response to stressors. This association may imply a worse clinical prognosis in people at risk for AD after the pandemic, and thus deserves to be considered by clinicians.greater\n\nClinicalTrials.gov Identifier NCT02485730.", "doi": "10.1212/WNL.0000000000200948", "pmid": "35918160", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "WNL.0000000000200948"}, {"db": "ClinicalTrials.gov", "key": "NCT02485730"}], "notes": [], "created": "2022-08-11T12:02:17.685Z", "modified": "2022-08-11T12:02:17.790Z"}, {"entity": "publication", "iuid": "2cbd31a1040043d09247c2097750ee5e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2cbd31a1040043d09247c2097750ee5e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2cbd31a1040043d09247c2097750ee5e"}}, "title": "Lockdown and No Lockdown: How Norwegian and Swedish Elite Athletes Managed Preparations for Tokyo 2020 and Mental Health Challenges in the Shadow of COVID-19.", "authors": [{"family": "Lundqvist", "given": "Carolina", "initials": "C"}, {"family": "Kristiansen", "given": "Elsa", "initials": "E"}], "type": "journal article", "published": "2022-08-02", "journal": {"title": "Front Sports Act Living", "issn": "2624-9367", "volume": "4", "pages": "918825", "issn-l": null}, "abstract": "The present study explored Norwegian and Swedish Olympic aspirants' perceived challenges for the preparations of Tokyo 2020 Olympic Games (OG) and risk and protective factors for mental health. The focus for this study was the timespan between the declaration of the postponement of Tokyo 2020 and the final months before the Games. A secondary purpose was to explore experiences of both elite athletes affected by lockdown (i.e., Norwegian athletes) and elite athletes not affected by lockdown in their home country (i.e., Swedish athletes). Twelve elite athletes (Norwegian: n = 6; Swedish: n = 6; Women: n = 6; Men: n = 6) with a mean age of 28.25 (SD = 3.60) participated. Semi-structured interviews were conducted between April and June 2021. Seven athletes had qualified and five were still trying to qualify. Eight of the interviewed athletes had previous experiences with OG participation. Template analysis revealed two main themes: (a) challenges and risk-factors for mental health and (b) protective factors. The pandemic exposed athletes to several psychological strains like uncertainty and difficulties with planning and preparations for the OG and personal and social challenges (i.e., worry about physical health and risk of overtraining, social contacts, identity, and life issues). Protective factors included perceived benefits of increased recovery and time for quality training. The athletes used several coping strategies and self-care behaviors (e.g., focus on the controllable, playfulness, putting sports in perspective, daily routines, short-term goals, working or studying for personal development) and they tapped into various internal and external psychosocial resources perceived as protective for mental health, personal growth, resiliency, and adjustment to the pandemic. The holistic perspectives used contribute to an increased understanding of elite sport athletes' mental health needs in stressful and unforeseen situations such as a pandemic.", "doi": "10.3389/fspor.2022.918825", "pmid": "35982760", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9378964"}], "notes": [], "created": "2022-09-12T18:45:36.583Z", "modified": "2022-09-12T18:45:36.595Z"}, {"entity": "publication", "iuid": "31f243e37ec049429d996fc9718824f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/31f243e37ec049429d996fc9718824f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/31f243e37ec049429d996fc9718824f7"}}, "title": "Increased incidence of childhood type 1 diabetes during the COVID-19 pandemic. Figures from an Italian tertiary care center.", "authors": [{"family": "Schiaffini", "given": "Riccardo", "initials": "R", "orcid": "0000-0002-9527-2353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5246b36ef614d9fb2ceb112e0cd80ba.json"}}, {"family": "Deodati", "given": "Annalisa", "initials": "A"}, {"family": "Rapini", "given": "Novella", "initials": "N"}, {"family": "Pampanini", "given": "Valentina", "initials": "V"}, {"family": "Cianfarani", "given": "Stefano", "initials": "S"}], "type": "letter", "published": "2022-08-02", "journal": {"title": "J Diabetes", "issn": "1753-0407", "issn-l": null}, "abstract": null, "doi": "10.1111/1753-0407.13298", "pmid": "35916392", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-11T12:02:59.090Z", "modified": "2022-08-11T12:02:59.148Z"}, {"entity": "publication", "iuid": "115d909766f44e4db43983d9bbdeb689", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/115d909766f44e4db43983d9bbdeb689.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/115d909766f44e4db43983d9bbdeb689"}}, "title": "Computational models predicting the early development of the COVID-19 pandemic in Sweden: systematic review, data synthesis, and secondary validation of accuracy", "authors": [{"family": "Gerlee", "given": "Philip", "initials": "P", "orcid": "0000-0001-8503-0177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ba426c1ab741e781d2b9cd09a0b830.json"}}, {"family": "J\u00f6ud", "given": "Anna", "initials": "A", "orcid": "0000-0001-7192-4911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e038a5ce2f5a47bd89e7c221651a3d24.json"}}, {"family": "Spreco", "given": "Armin", "initials": "A"}, {"family": "Timpka", "given": "Toomas", "initials": "T"}], "type": "journal-article", "published": "2022-08-02", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "13256", "issn-l": "2045-2322"}, "abstract": "Computational models for predicting the early course of the COVID-19 pandemic played a central role in policy-making at regional and national levels. We performed a systematic review, data synthesis, and secondary validation of studies that reported on prediction models addressing the early stages of the COVID-19 pandemic in Sweden. A literature search in January 2021 based on the search triangle model identified 1672 peer-reviewed articles, preprints and reports. After applying inclusion criteria 52 studies remained out of which 12 passed a Risk of Bias Opinion Tool. When comparing model predictions with actual outcomes only 4 studies exhibited an acceptable forecast (mean absolute percentage error, MAPE < 20%). Models that predicted disease incidence could not be assessed due to the lack of reliable data during 2020. Drawing conclusions about the accuracy of the models with acceptable methodological quality was challenging because some models were published before the time period for the prediction, while other models were published during the prediction period or even afterwards. We conclude that the forecasting models involving Sweden developed during the early stages of the COVID-19 pandemic in 2020 had limited accuracy. The knowledge attained in this study can be used to improve the preparedness for coming pandemics.", "doi": "10.1038/s41598-022-16159-6", "pmid": "35918476", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9345013"}, {"db": "pii", "key": "10.1038/s41598-022-16159-6"}], "notes": [], "created": "2022-08-11T12:01:58.698Z", "modified": "2023-06-19T14:58:56.393Z"}, {"entity": "publication", "iuid": "c3a29385ba7848e4b7dae4b8db98a818", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3a29385ba7848e4b7dae4b8db98a818.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3a29385ba7848e4b7dae4b8db98a818"}}, "title": "The Role of Neutrophil-to-Lymphocyte Ratio in Risk Stratification and Prognostication of COVID-19: A Systematic Review and Meta-Analysis.", "authors": [{"family": "Parthasarathi", "given": "Ashwaghosha", "initials": "A", "orcid": "0000-0002-7270-0247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c0a5e6837a421cbbb0314628ae7f24.json"}}, {"family": "Padukudru", "given": "Sunag", "initials": "S", "orcid": "0000-0003-4088-9548", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/815e161a476946c689f312fd8986b5a0.json"}}, {"family": "Arunachal", "given": "Sumalata", "initials": "S"}, {"family": "Basavaraj", "given": "Chetak Kadabasal", "initials": "CK"}, {"family": "Krishna", "given": "Mamidipudi Thirumala", "initials": "MT", "orcid": "0000-0003-2109-5777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cfbac9ab1b3c4afea2f7de6b60fd162a.json"}}, {"family": "Ganguly", "given": "Koustav", "initials": "K", "orcid": "0000-0001-8531-8154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58b2e0d7853a4b32920e54042e95061d.json"}}, {"family": "Upadhyay", "given": "Swapna", "initials": "S"}, {"family": "Anand", "given": "Mahesh Padukudru", "initials": "MP"}], "type": "journal article", "published": "2022-08-01", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "Several studies have proposed that the neutrophil-lymphocyte ratio (NLR) is one of the various biomarkers that can be useful in assessing COVID-19 disease-related outcomes. Our systematic review analyzes the relationship between on-admission NLR values and COVID-19 severity and mortality. Six different severity criteria were used. A search of the literature in various databases was conducted from 1 January 2020 to 1 May 2021. We calculated the pooled standardized mean difference (SMD) for the collected NLR values. A meta-regression analysis was performed, looking at the length of hospitalization and other probable confounders, such as age, gender, and comorbidities. A total of sixty-four studies were considered, which included a total of 15,683 patients. The meta-analysis showed an SMD of 3.12 (95% CI: 2.64-3.59) in NLR values between severe and non-severe patients. A difference of 3.93 (95% CI: 2.35-5.50) was found between survivors and non-survivors of the disease. Upon summary receiver operating characteristics analysis, NLR showed 80.2% (95% CI: 74.0-85.2%) sensitivity and 75.8% (95% CI: 71.3-79.9%) specificity for the prediction of severity and 78.8% (95% CI: 73.5-83.2%) sensitivity and 73.0% (95% CI: 68.4-77.1%) specificity for mortality, and was not influenced by age, gender, or co-morbid conditions. Conclusion: On admission, NLR predicts both severity and mortality in COVID-19 patients, and an NLR &gt; 6.5 is associated with significantly greater the odds of mortality.", "doi": "10.3390/vaccines10081233", "pmid": "36016121", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "vaccines10081233"}, {"db": "pmc", "key": "PMC9415708"}], "notes": [], "created": "2022-09-12T19:11:18.061Z", "modified": "2022-09-12T19:11:18.188Z"}, {"entity": "publication", "iuid": "f6ab87d2afb44facbaa5e35b6a5dcb4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6ab87d2afb44facbaa5e35b6a5dcb4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6ab87d2afb44facbaa5e35b6a5dcb4d"}}, "title": "Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia.", "authors": [{"family": "Zhang", "given": "Qian", "initials": "Q", "orcid": "0000-0002-9040-3289", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/341c0cb0fa7d41448e55344c82d68358.json"}}, {"family": "Matuozzo", "given": "Daniela", "initials": "D", "orcid": "0000-0001-9514-3837", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f3ea98ae5ed468a81d92fd3c5d4782b.json"}}, {"family": "Le Pen", "given": "J\u00e9r\u00e9mie", "initials": "J", "orcid": "0000-0001-7025-9526", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/419c9219d4664b899addbcdde33b7551.json"}}, {"family": "Lee", "given": "Danyel", "initials": "D", "orcid": "0000-0003-3124-0245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a658026d0b444541bc6fa15b1de790ec.json"}}, {"family": "Moens", "given": "Leen", "initials": "L", "orcid": "0000-0002-5347-6526", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49147a953e1c4721bd0181e5d0a3dafb.json"}}, {"family": "Asano", "given": "Takaki", "initials": "T", "orcid": "0000-0003-1424-2433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cce1fe0e7df44b2a7a49fbcb45b1a5a.json"}}, {"family": "Bohlen", "given": "Jonathan", "initials": "J", "orcid": "0000-0003-0458-9484", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9aedda86e36413883cc6558c66727e1.json"}}, {"family": "Liu", "given": "Zhiyong", "initials": "Z", "orcid": "0000-0001-6473-348X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d7b2869a5874679b1b6fdccade088a2.json"}}, {"family": "Moncada-Velez", "given": "Marcela", "initials": "M", "orcid": "0000-0002-3073-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c543a8539a6430b8ff5cd9cf5875bf9.json"}}, {"family": "Kendir-Demirkol", "given": "Yasemin", "initials": "Y", "orcid": "0000-0001-8016-5224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d48a0443bd049bea3e4ab80b48239c3.json"}}, {"family": "Jing", "given": "Huie", "initials": "H", "orcid": "0000-0001-6283-3452", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8904017c1a114ad7aa4a64850450f299.json"}}, {"family": "Bizien", "given": "Lucy", "initials": "L", "orcid": "0000-0001-9163-9122", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ffde5891cfed41db9dc0265155576cc4.json"}}, {"family": "Marchal", "given": "Astrid", "initials": "A", "orcid": "0000-0003-0648-8126", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbf87e3c4eb34dadb828c6f58276e8b0.json"}}, {"family": "Abolhassani", "given": "Hassan", "initials": "H", "orcid": "0000-0002-4838-0407", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36fb362d046748b0a62822960ce20edd.json"}}, {"family": "Delafontaine", "given": "Selket", "initials": "S", "orcid": "0000-0002-8985-8155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/505e15f7fd9e41d3b3f3a9fa8bb3a123.json"}}, {"family": "Bucciol", "given": "Giorgia", "initials": "G", "orcid": "0000-0001-5004-0738", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fde316a981d84407a32dca71fd6f39ba.json"}}, {"family": "COVID Human Genetic Effort", "given": "", "initials": ""}, {"family": "Bayhan", "given": "Gulsum Ical", "initials": "GI", "orcid": "0000-0002-1423-4348", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/974e5811368646b5a90ccc027212db3d.json"}}, {"family": "Keles", "given": "Sevgi", "initials": "S", "orcid": "0000-0001-7344-8947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08e51d507698439cbf08326d10be2310.json"}}, {"family": "Kiykim", "given": "Ayca", "initials": "A", "orcid": "0000-0001-5821-3963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/999518defe2c4fabb42480ccef8ad8c0.json"}}, {"family": "Hancerli", "given": "Selda", "initials": "S", "orcid": "0000-0002-3216-2413", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7414c31e5b704991a1e81912d14eddc8.json"}}, {"family": "Haerynck", "given": "Filomeen", "initials": "F", "orcid": "0000-0001-9161-7361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbe7ce932ab14405b7ad1c1153d39972.json"}}, {"family": "Florkin", "given": "Benoit", "initials": "B", "orcid": "0000-0001-7318-8348", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc4ebf10fd104544803675f66863291b.json"}}, {"family": "Hatipoglu", "given": "Nevin", "initials": "N", "orcid": "0000-0003-2858-0150", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c14f98b8f5e24280a669fa49a297c3dc.json"}}, {"family": "Ozcelik", "given": "Tayfun", "initials": "T", "orcid": "0000-0001-5937-1082", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6665d35db77044aa847a5f394332bb86.json"}}, {"family": "Morelle", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-6511-1674", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0ef829b533e45edb15a3e5c03c2db65.json"}}, {"family": "Zatz", "given": "Mayana", "initials": "M", "orcid": "0000-0003-3970-8025", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d37e5fa0191b433386921fff2e34245b.json"}}, {"family": "Ng", "given": "Lisa F P", "initials": "LFP", "orcid": "0000-0003-4071-5222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0502452f11bf44ba96a6cb952a82a1f5.json"}}, {"family": "Lye", "given": "David Chien", "initials": "DC", "orcid": "0000-0003-0324-0205", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d274935e03904ae2935f07246404d97d.json"}}, {"family": "Young", "given": "Barnaby Edward", "initials": "BE", "orcid": "0000-0003-1010-2230", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/319b1cd3f3b540edb9f9651160eefcb3.json"}}, {"family": "Leo", "given": "Yee-Sin", "initials": "YS", "orcid": "0000-0003-4978-5825", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ca28661a9df44a7b95577da156b54c9.json"}}, {"family": "Dalgard", "given": "Clifton L", "initials": "CL", "orcid": "0000-0003-2025-8239", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22f57b7602714f59bfbcc96a936d77a8.json"}}, {"family": "Lifton", "given": "Richard P", "initials": "RP", "orcid": "0000-0002-5745-5984", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/354dc2abf2a04896b69ef5cba011679f.json"}}, {"family": "Renia", "given": "Laurent", "initials": "L", "orcid": "0000-0003-0349-1557", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/957c86bd7cc941e0a2e7c7de9817e5ce.json"}}, {"family": "Meyts", "given": "Isabelle", "initials": "I", "orcid": "0000-0003-1214-0302", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a5399449f4c4d338b683632944008fb.json"}}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E", "orcid": "0000-0002-7358-9157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c50d261245743539a5813daffcaab72.json"}}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L", "orcid": "0000-0002-8635-9609", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b532108235c415891981621f58ddbfd.json"}}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q", "orcid": "0000-0003-1990-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94a32366862b470eba3a15521b9be290.json"}}, {"family": "Boisson", "given": "Bertrand", "initials": "B", "orcid": "0000-0001-5240-3555", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1dc2dc22a5d240dc889707226eb18a36.json"}}, {"family": "Bastard", "given": "Paul", "initials": "P", "orcid": "0000-0002-5926-8437", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e3388c840d04a25824530a9bf999f01.json"}}, {"family": "Su", "given": "Helen C", "initials": "HC", "orcid": "0000-0002-5582-9110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad550813f03540d9a8240a3d96ad0829.json"}}, {"family": "Boisson-Dupuis", "given": "St\u00e9phanie", "initials": "S", "orcid": "0000-0002-7115-116X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92c785f151bb490aa85764eb62c0508e.json"}}, {"family": "Abel", "given": "Laurent", "initials": "L", "orcid": "0000-0001-7016-6493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fd6c4593c8c492a8dad8e49cb7a832a.json"}}, {"family": "Rice", "given": "Charles M", "initials": "CM", "orcid": "0000-0003-3087-8079", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb21eff3730f4b64a8ebed8b04a9038c.json"}}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY", "orcid": "0000-0002-9449-3672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/273e17cf54524572baff11761631d846.json"}}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5369fe152ac94b5a81d4f913d85940a7.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL", "orcid": "0000-0002-7782-4169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1aca66ab7c39465faf2de03fa8a6722f.json"}}], "type": "journal article", "published": "2022-08-01", "journal": {"title": "J Exp Med", "issn": "1540-9538", "volume": "219", "issue": "8", "issn-l": null}, "abstract": "Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical COVID-19 pneumonia in unvaccinated adults. The risk of COVID-19 pneumonia in unvaccinated children, which is much lower than in unvaccinated adults, remains unexplained. In an international cohort of 112 children (<16 yr old) hospitalized for COVID-19 pneumonia, we report 12 children (10.7%) aged 1.5-13 yr with critical (7 children), severe (3), and moderate (2) pneumonia and 4 of the 15 known clinically recessive and biochemically complete inborn errors of type I IFN immunity: X-linked recessive TLR7 deficiency (7 children) and autosomal recessive IFNAR1 (1), STAT2 (1), or TYK2 (3) deficiencies. Fibroblasts deficient for IFNAR1, STAT2, or TYK2 are highly vulnerable to SARS-CoV-2. These 15 deficiencies were not found in 1,224 children and adults with benign SARS-CoV-2 infection without pneumonia (P = 1.2 \u00d7 10-11) and with overlapping age, sex, consanguinity, and ethnicity characteristics. Recessive complete deficiencies of type I IFN immunity may underlie \u223c10% of hospitalizations for COVID-19 pneumonia in children.", "doi": "10.1084/jem.20220131", "pmid": "35708626", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "213287"}, {"db": "pmc", "key": "PMC9206114"}], "notes": [], "created": "2022-06-20T18:08:01.020Z", "modified": "2022-08-17T12:48:34.870Z"}, {"entity": "publication", "iuid": "6deffae81fdc4c21bf7b2b1d630eff8f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6deffae81fdc4c21bf7b2b1d630eff8f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6deffae81fdc4c21bf7b2b1d630eff8f"}}, "title": "Pharmacovigilance regulatory actions by national pharmacovigilance centres in Arab countries following COVID-19 pandemic.", "authors": [{"family": "Al-Zubiedi", "given": "Sameh A", "initials": "SA", "orcid": "0000-0003-0888-5328", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/686c3af4ef524cdfbcedbae63dba9c77.json"}}, {"family": "Younus", "given": "Manal", "initials": "M"}, {"family": "Al-Khalidi", "given": "Sara", "initials": "S"}, {"family": "Ekilo", "given": "Magnus", "initials": "M"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM", "orcid": "0000-0002-5630-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5162aab03bc04dafa809108461f18667.json"}}], "type": "journal article", "published": "2022-08-01", "journal": {"title": "Expert Opin Drug Saf", "issn": "1744-764X", "issn-l": null}, "abstract": "Pharmacovigilance (PV) activities were affected by COVID-19. Therefore, several health authorities around the world have issued guidelines and practices to ensure that PV activities are maintained and continued during the pandemic. This study aimed to assess the impact of COVID-19 on the preparedness and performance of national PV systems in 14 Arab countries.\n\nThis was a cross-sectional study that was conducted between July and October 2020. National PV centres in 18 Arab countries were invited to participate in this study. Descriptive analysis was used to summarize and present the results of this study.\n\nResponses were obtained from 14 (77.8%) countries. Adverse events reporting was the main PV activity that was covered by PV guidelines and practices. National guidelines and practices covered other PV activities in 8 (57.14%) of the participating countries. Performance and practices of national PV centres vary considerably among participating countries during the pandemic.\n\nThe findings highlight the differences in preparedness and performance of different national PV centres in participating Arab countries. Improving digital infrastructure among participating countries could serve as a useful tool to minimize the impact of the pandemic on PV activities.", "doi": "10.1080/14740338.2022.2108398", "pmid": "35915555", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-08-11T12:03:26.248Z", "modified": "2022-08-11T12:03:26.339Z"}, {"entity": "publication", "iuid": "736b58cbf52142a6926bd2b650b86d2b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/736b58cbf52142a6926bd2b650b86d2b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/736b58cbf52142a6926bd2b650b86d2b"}}, "title": "Ion channel inhibition with amiodarone or verapamil in symptomatic hospitalized nonintensive-care COVID-19 patients: The ReCOVery-SIRIO randomized trial.", "authors": [{"family": "Navarese", "given": "Eliano P", "initials": "EP"}, {"family": "Podhajski", "given": "Przemys\u0142aw", "initials": "P"}, {"family": "Andreotti", "given": "Felicita", "initials": "F"}, {"family": "La Torre", "given": "Giuseppe", "initials": "G"}, {"family": "Gajda", "given": "Robert", "initials": "R"}, {"family": "Radziwanowski", "given": "Adrian", "initials": "A"}, {"family": "Nowicka", "given": "Ma\u0142gorzata", "initials": "M"}, {"family": "Bukowski", "given": "Pawe\u0142", "initials": "P"}, {"family": "Gajda", "given": "Jacek", "initials": "J"}, {"family": "Omy\u0142a", "given": "Maciej", "initials": "M"}, {"family": "Lackowski", "given": "Piotr", "initials": "P"}, {"family": "Piasecki", "given": "Maciej", "initials": "M"}, {"family": "Jasiewicz", "given": "Ma\u0142gorzata", "initials": "M"}, {"family": "Szyma\u0144ski", "given": "Pawe\u0142", "initials": "P"}, {"family": "Pietrzykowski", "given": "\u0141ukasz", "initials": "\u0141"}, {"family": "Michalski", "given": "Piotr", "initials": "P"}, {"family": "Kubica", "given": "Aldona", "initials": "A"}, {"family": "Urbanowicz", "given": "Iwona", "initials": "I"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}, {"family": "Conte", "given": "Max", "initials": "M"}, {"family": "Pinkas", "given": "Jaros\u0142aw", "initials": "J"}, {"family": "Brouwer", "given": "Marc A", "initials": "MA"}, {"family": "Kubica", "given": "Jacek", "initials": "J"}], "type": "journal article", "published": "2022-08-01", "journal": {"title": "Cardiol J", "issn": "1898-018X", "issn-l": null}, "abstract": "Ion channel inhibition may offer protection against coronavirus disease 2019 (COVID-19). Inflammation and reduced platelet count occur during COVID-19 but precise quantification of risk thresholds is unclear. The Recovery-SIRIO study aimed to assess clinical effects of amiodarone and verapamil and to relate patient phenotypes to outcomes.\n\nRECOVERY-SIRIO is a multicenter open-label 1:1:1 investigator-initiated randomized trial with blinded event adjudication. A sample of 804 symptomatic hospitalized nonintensive-care COVID-19 patients, follow-up for 28 days was initially planned.\n\nThe trial was stopped when a total of 215 patients had been randomized to amiodarone (n = 71), verapamil (n = 72) or standard care alone (n = 72). At 15 days, the hazard ratio (hazard ratio [HR], 95% confidence interval [CI]) for clinical improvement was 0.77 (0.52-1.14) with amiodarone and 0.97 (0.81-1.17) with verapamil as compared to usual care. Clinically relevant associations were found between mortality or lack of clinical improvement and higher peak C-reactive protein (CRP) levels or nadir platelet count at 7, 10 and 15 days. Mortality rate increased by 73% every 5 mg/dL increment in peak CRP (HR 1.73, 95% CI 1.27-2.37) and was two-fold higher for every decrement of 100 units in nadir platelet count (HR 2.19, 95% CI 1.37-3.51). By cluster analysis, thresholds of 5 mg/dL for peak CRP and 187 \u00d710\u00b3/mcL for nadir platelet count identified the phenogroup at greatest risk of dying.\n\nIn this randomized trial, neither amiodarone nor verapamil were found to significantly accelerate short-term clinical improvement. Peak CRP and nadir platelet counts were associated with increased mortality both in isolation and by cluster analysis.", "doi": "10.5603/CJ.a2022.0072", "pmid": "35912711", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "VM/OJS/J/88627"}], "notes": [], "created": "2022-08-11T12:04:30.224Z", "modified": "2022-08-11T12:04:30.261Z"}, {"entity": "publication", "iuid": "c74a65a0291343bcb2edbb2ba2f7f3c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c74a65a0291343bcb2edbb2ba2f7f3c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c74a65a0291343bcb2edbb2ba2f7f3c0"}}, "title": "Can aerosols-generating dental, oral and maxillofacial, and orthopedic surgical procedures lead to disease transmission? An implication on the current COVID-19 pandemic.", "authors": [{"family": "Al-Moraissi", "given": "Essam Ahmed", "initials": "EA"}, {"family": "Kaur", "given": "Amanjot", "initials": "A"}, {"family": "G\u00fcnther", "given": "Frank", "initials": "F"}, {"family": "Neff", "given": "Andreas", "initials": "A"}, {"family": "Christidis", "given": "Nikolaos", "initials": "N"}], "type": "systematic review", "published": "2022-08-01", "journal": {"title": "Front Oral Health", "issn": "2673-4842", "volume": "3", "pages": "974644", "issn-l": null}, "abstract": "Various dental, maxillofacial, and orthopedic surgical procedures (DMOSP) have been known to produce bioaerosols, that can lead to the transmission of various infectious diseases. Hence, a systematic review (SR) aimed at generating evidence of aerosols generating DMOSP that can result in the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), further investigating their infectivity and assessing the role of enhanced personal protective equipment (PPE) an essential to preventing the spreading of SARS-CoV-2 during aerosol-generating procedures (AGPs). This SR was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (PRISMA) guidelines based on a well-designed Population, Intervention, Comparison, Outcomes and Study (PICOS) framework, and various databases were searched to retrieve the studies which assessed potential aerosolization during DMOSP. This SR included 80 studies (59 dental and 21 orthopedic) with 7 SR, 47 humans, 5 cadaveric, 16 experimental, and 5 animal studies that confirmed the generation of small-sized < 5 \u03bcm particles in DMOSP. One study confirmed that HIV could be transmitted by aerosolized blood generated by an electric saw and bur. There is sufficient evidence that DMOSP generates an ample amount of bioaerosols, but the infectivity of these bioaerosols to transmit diseases like SARS-CoV-2 generates very weak evidence but still, this should be considered. Confirmation through isolation and culture of viable virus in the clinical environment should be pursued. An evidence provided by the current review was gathered by extrapolation from available experimental and empirical evidence not based on SARS-CoV-2. The results of the present review, therefore, should be interpreted with great caution.", "doi": "10.3389/froh.2022.974644", "pmid": "35979536", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9376374"}], "notes": [], "created": "2022-09-12T18:41:22.127Z", "modified": "2022-09-12T18:41:32.412Z"}, {"entity": "publication", "iuid": "6c5019a8ad1f4e78beb9ad8e3f80fb4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c5019a8ad1f4e78beb9ad8e3f80fb4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c5019a8ad1f4e78beb9ad8e3f80fb4d"}}, "title": "Acute pericarditis in patients receiving coronavirus disease 2019 vaccines: a case series from the community.", "authors": [{"family": "Dini", "given": "Frank L", "initials": "FL"}, {"family": "Franzoni", "given": "Ferdinando", "initials": "F"}, {"family": "Scarf\u00f2", "given": "Giorgia", "initials": "G"}, {"family": "Pugliese", "given": "Nicola Riccardo", "initials": "NR"}, {"family": "Imazio", "given": "Massimo", "initials": "M"}], "type": "journal article", "published": "2022-08-01", "journal": {"title": "J Cardiovasc Med (Hagerstown)", "issn": "1558-2035", "volume": "23", "issue": "8", "pages": "551-558", "issn-l": null}, "abstract": "International agencies reported that cases of pericarditis occur very rarely following the administration of coronavirus disease 2019 (COVID-19) vaccines. Herewith, we described a series of patients from the community diagnosed with acute pericarditis after vaccination.\n\nWe retrospectively included 28 patients (median age 51 years, 79% female) with or without a positive history of acute respiratory syndrome coronavirus 2 recovered infection who were diagnosed with acute pericarditis following the administration of COVID-19 vaccine. We excluded specific identifiable causes of pericarditis, including infectious, autoimmune, neoplastic and metabolic disease. Patients were referred for a complete cardiovascular evaluation. Transthoracic echocardiography (TTE) was performed and diagnosis of acute pericarditis was achieved according to current guidelines.\n\nThere were 16 patients administered with Pfizer-BioNTech/Comirnaty vaccine, 8 with Moderna/Spikevax vaccine and 4 with Astra Zeneca/Vaxzevria vaccine. Nine patients had been previously diagnosed with COVID-19, while the others had no prior history of COVID-19. Eleven patients had no comorbidity while the others had between one and four comorbidities. Ten patients had a history of rheumatic or autoimmune diseases. Chest pain was present in 24 patients. Minor ECG abnormalities were detected in 10 patients, T-wave inversion in 6, and 7 patients had concave ST elevation. The majority of patients showed mild pericardial effusions at TTE. Only two patients exhibited large pericardial effusions.\n\nThis case series shows a higher incidence of acute pericarditis in patients administered with COVID-19 vaccines than previously estimated, probably because of a more comprehensive assessment of clinical as well as echocardiographic parameters.", "doi": "10.2459/JCM.0000000000001342", "pmid": "35904995", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "01244665-990000000-00028"}], "notes": [], "created": "2022-08-12T08:31:22.928Z", "modified": "2022-08-12T08:31:22.933Z"}, {"entity": "publication", "iuid": "68b51851f33c4f63b18049d8f560ce50", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68b51851f33c4f63b18049d8f560ce50.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68b51851f33c4f63b18049d8f560ce50"}}, "title": "Zanubrutinib versus bendamustine and rituximab in untreated chronic lymphocytic leukaemia and small lymphocytic lymphoma (SEQUOIA): a randomised, controlled, phase 3 trial.", "authors": [{"family": "Tam", "given": "Constantine S", "initials": "CS"}, {"family": "Brown", "given": "Jennifer R", "initials": "JR"}, {"family": "Kahl", "given": "Brad S", "initials": "BS"}, {"family": "Ghia", "given": "Paolo", "initials": "P"}, {"family": "Giannopoulos", "given": "Krzysztof", "initials": "K"}, {"family": "Jurczak", "given": "Wojciech", "initials": "W"}, {"family": "\u0160imkovi\u010d", "given": "Martin", "initials": "M"}, {"family": "Shadman", "given": "Mazyar", "initials": "M"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Laurenti", "given": "Luca", "initials": "L"}, {"family": "Walker", "given": "Patricia", "initials": "P"}, {"family": "Opat", "given": "Stephen", "initials": "S"}, {"family": "Chan", "given": "Henry", "initials": "H"}, {"family": "Ciepluch", "given": "Hanna", "initials": "H"}, {"family": "Greil", "given": "Richard", "initials": "R"}, {"family": "Tani", "given": "Monica", "initials": "M"}, {"family": "Trn\u011bn\u00fd", "given": "Marek", "initials": "M"}, {"family": "Brander", "given": "Danielle M", "initials": "DM"}, {"family": "Flinn", "given": "Ian W", "initials": "IW"}, {"family": "Grosicki", "given": "Sebastian", "initials": "S"}, {"family": "Verner", "given": "Emma", "initials": "E"}, {"family": "Tedeschi", "given": "Alessandra", "initials": "A"}, {"family": "Li", "given": "Jianyong", "initials": "J"}, {"family": "Tian", "given": "Tian", "initials": "T"}, {"family": "Zhou", "given": "Lei", "initials": "L"}, {"family": "Marimpietri", "given": "Carol", "initials": "C"}, {"family": "Paik", "given": "Jason C", "initials": "JC"}, {"family": "Cohen", "given": "Aileen", "initials": "A"}, {"family": "Huang", "given": "Jane", "initials": "J"}, {"family": "Robak", "given": "Tadeusz", "initials": "T"}, {"family": "Hillmen", "given": "Peter", "initials": "P"}], "type": "clinical trial, phase iii", "published": "2022-08-00", "journal": {"title": "Lancet Oncol", "issn": "1474-5488", "volume": "23", "issue": "8", "pages": "1031-1043", "issn-l": null}, "abstract": "Zanubrutinib is a next-generation, selective Bruton tyrosine kinase inhibitor with efficacy in relapsed chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). We compared zanubrutinib with bendamustine-rituximab to determine its effectiveness as frontline therapy in patients with CLL or SLL.\n\nWe conducted an open-label, multicentre, phase 3 study at 153 academic or community hospitals in 14 countries and regions. Eligible patients had untreated CLL or SLL requiring treatment as per International Workshop on CLL criteria; were aged 65 years or older, or 18 years or older and had comorbidities; and had an Eastern Cooperative Oncology Group performance status score of 0-2. A central interactive web response system randomly assigned patients without del(17)(p13\u00b71) to zanubrutinib (group A) or bendamustine-rituximab (group B) by sequential block method (permutated blocks with a random block size of four). Patients with del(17)(p13\u00b71) were enrolled in group C and received zanubrutinib. Zanubrutinib was administered orally at 160 mg twice per day (28-day cycles); bendamustine at 90 mg/m2 of body surface area on days 1 and 2 for six cycles plus rituximab at 375 mg/m2 of body surface area the day before or on day 1 of cycle 1, and 500 mg/m2 of body surface area on day 1 of cycles 2-6, were administered intravenously. The primary endpoint was progression-free survival per independent review committee in the intention-to-treat population in groups A and B, with minimum two-sided \u03b1 of 0\u00b705 for superiority. Safety was analysed in all patients who received at least one dose of study treatment. The study is registered with ClinicalTrials.gov, NCT03336333, and is closed to recruitment.\n\nBetween Oct 31, 2017, and July 22, 2019, 590 patients were enrolled; patients without del(17)(p13\u00b71) were randomly assigned to zanubrutinib (group A; n=241) or bendamustine-rituximab (group B; n=238). At median follow-up of 26\u00b72 months (IQR 23\u00b77-29\u00b76), median progression-free survival per independent review committee was not reached in either group (group A 95% CI not estimable [NE] to NE; group B 28\u00b71 months to NE). Progression-free survival was significantly improved in group A versus group B (HR 0\u00b742 [95% CI 0\u00b728 to 0\u00b763]; two-sided p<0\u00b70001). The most common grade 3 or worse adverse event was neutropenia (27 [11%] of 240 patients in group A, 116 [51%] of 227 in group B, and 17 [15%] of 111 patients in group C). Serious adverse events occurred in 88 (37%) of 240 patients in group A, 113 (50%) of 227 patients in group B, and 45 (41%) of 111 patients in group C. Adverse events leading to death occurred in 11 (5%) of 240 patients in group A, 12 (5%) of 227 patients in group B, and three (3%) of 111 patients in group C, most commonly due to COVID-19 (four [2%] of 240 patients in group A), diarrhoea, and aspiration pneumonia (two each [1%] of 227 patients in group B).\n\nZanubrutinib significantly improved progression-free survival versus bendamustine-rituximab, with an acceptable safety profile consistent with previous studies. These data support zanubrutinib as a potential new treatment option for untreated CLL and SLL.\n\nBeiGene.", "doi": "10.1016/S1470-2045(22)00293-5", "pmid": "35810754", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1470-2045(22)00293-5"}, {"db": "ClinicalTrials.gov", "key": "NCT03336333"}], "notes": [], "created": "2022-08-17T10:39:58.703Z", "modified": "2022-08-17T10:39:58.741Z"}, {"entity": "publication", "iuid": "0e5238a4af7444efb0b085cb8e289129", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e5238a4af7444efb0b085cb8e289129.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e5238a4af7444efb0b085cb8e289129"}}, "title": "Young children's voices in an unlocked Sweden during the COVID-19 pandemic.", "authors": [{"family": "Jenholt Nolbris", "given": "M", "initials": "M", "orcid": "0000-0002-6911-1484", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f53d9c5dc5ff46149ef63e16dfa6d7a1.json"}}, {"family": "Ragnarsson", "given": "S", "initials": "S", "orcid": "0000-0002-0646-7184", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44ffe0f652d74510b8caa74f9fb1c01f.json"}}, {"family": "Brorsson", "given": "A-L", "initials": "AL", "orcid": "0000-0002-8136-6340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bdee85ca7c74d93a2881e22997192b7.json"}}, {"family": "Garcia de Avila", "given": "M", "initials": "M", "orcid": "0000-0002-6652-4427", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b1e6b2121ac40969728034efca6c6a9.json"}}, {"family": "Forsner", "given": "M", "initials": "M"}, {"family": "Kull", "given": "I", "initials": "I"}, {"family": "Olinder", "given": "A L", "initials": "AL"}, {"family": "Mattson", "given": "J", "initials": "J"}, {"family": "Nilsson", "given": "S", "initials": "S"}, {"family": "Rullander", "given": "A-C", "initials": "AC"}, {"family": "Rydstr\u00f6m", "given": "L-L", "initials": "LL", "orcid": "0000-0002-1007-1959", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad5251de283d4f73b0c2ac600a34a19a.json"}}, {"family": "Olaya-Contreras", "given": "P", "initials": "P"}, {"family": "Berghammer", "given": "M", "initials": "M"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "volume": "50", "issue": "6", "pages": "693-702", "issn-l": "1403-4948"}, "abstract": "During the COVID-19 pandemic, Sweden was one of the few countries that rejected lockdowns in favour of recommendations for restrictions, including careful hand hygiene and social distancing. Preschools and primary schools remained open. Several studies have shown negative impacts of the pandemic on children, particularly high levels of anxiety. The study aim was to explore how Swedish school-aged children aged 6-14 years, experienced the COVID-19 pandemic and their perceived anxiety.\n\nIn total, 774 children aged 6-14 years and their guardians answered an online questionnaire containing 24 questions, along with two instruments measuring anxiety: the Children's Anxiety Questionnaire and the Numerical Rating Scale. A convergent parallel mixed-methods design was used for analysing the quantitative and qualitative data. Each data source was first analysed separately, followed by a merged interpretative analysis.\n\nThe results showed generally low levels of anxiety, with no significant sex differences. Children who refrained from normal social activities or group activities (n=377) had significantly higher levels of anxiety. Most of the children were able to appreciate the bright side of life, despite the social distancing and refraining from activities, which prevented them from meeting and hugging their loved ones.\n\nThese Swedish children generally experienced low levels of anxiety, except those who refrained from social activities. Life was nonetheless mostly experienced as normal, largely because schools remained open. Keeping life as normal as possible could be one important factor in preventing higher anxiety and depression levels in children during a pandemic.", "doi": "10.1177/14034948221108250", "pmid": "35799462", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9361420"}], "notes": [], "created": "2022-08-17T10:45:35.107Z", "modified": "2023-01-13T13:37:17.582Z"}, {"entity": "publication", "iuid": "61c32411a7c54756878158ee59df6fed", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61c32411a7c54756878158ee59df6fed.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61c32411a7c54756878158ee59df6fed"}}, "title": "Validation of a noninvasive aMMP-8 point-of-care diagnostic methodology in COVID-19 patients with periodontal disease.", "authors": [{"family": "Gupta", "given": "Shipra", "initials": "S", "orcid": "0000-0003-2097-2459", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa6dd4cea3824827b3ead550b8267b2a.json"}}, {"family": "Mohindra", "given": "Ritin", "initials": "R"}, {"family": "Singla", "given": "Mohita", "initials": "M"}, {"family": "Khera", "given": "Sagar", "initials": "S"}, {"family": "Kumar", "given": "Amit", "initials": "A"}, {"family": "Rathnayake", "given": "Nilminie", "initials": "N"}, {"family": "Sorsa", "given": "Timo", "initials": "T"}, {"family": "Pf\u00fctzner", "given": "Andreas", "initials": "A"}, {"family": "R\u00e4is\u00e4nen", "given": "Ismo T", "initials": "IT", "orcid": "0000-0001-5821-5299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5688183e182e4194888dc98301077bab.json"}}, {"family": "Soni", "given": "Roop K", "initials": "RK"}, {"family": "Kanta", "given": "Poonam", "initials": "P"}, {"family": "Jain", "given": "Akanksha", "initials": "A"}, {"family": "Gauba", "given": "Krishan", "initials": "K"}, {"family": "Goyal", "given": "Kapil", "initials": "K"}, {"family": "Singh", "given": "Mini P", "initials": "MP"}, {"family": "Ghosh", "given": "Arnab", "initials": "A"}, {"family": "Kajal", "given": "Kamal", "initials": "K"}, {"family": "Mahajan", "given": "Varun", "initials": "V"}, {"family": "Suri", "given": "Vikas", "initials": "V"}, {"family": "Bhalla", "given": "Ashish", "initials": "A"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Clin Exp Dent Res", "issn": "2057-4347", "volume": "8", "issue": "4", "pages": "988-1001", "issn-l": null}, "abstract": "The aim of this study was to validate an active matrix metalloproteinase (MMP-8) point-of-care diagnostic tool in COVID-19 patients with periodontal disease.\n\nSeventy-two COVID-19-positive and 30 COVID-19-negative subjects were enrolled in the study. Demographic data were recorded, periodontal examination carried out, and chairside tests run for evaluating the expression of active MMP-8 (aMMP-8) in the site with maximum periodontal breakdown via gingival crevicular fluid sampling as well as via a mouth rinse-based kit for general disease activity. In COVID-19-positive patients, the kits were run again once the patients turned COVID-19 negative.\n\nThe overall (n = 102) sensitivity/specificity of the mouthrinse-based kits to detect periodontal disease was 79.41%/36.76% and that of site-specific kits was 64.71%/55.88% while adjusting for age, gender, and smoking status increased the sensitivity and specificity (82.35%/76.47% and 73.53%/88.24, respectively). Receiver operating characteristic (ROC) analysis for the adjusted model revealed very good area under the ROC curve 0.746-0.869 (p < .001) and 0.740-0.872 (p < .001) (the aMMP-8 mouth rinse and site-specific kits, respectively). No statistically significant difference was observed in the distribution of results of aMMP-8 mouth rinse test (p = .302) and aMMP-8 site-specific test (p = .189) once the subjects recovered from COVID-19.\n\nThe findings of the present study support the aMMP-8 point-of-care testing (PoCT) kits as screening tools for periodontitis in COVID-19 patients. The overall screening accuracy can be further increased by utilizing adjunctively risk factors of periodontitis. The reported noninvasive, user-friendly, and objective PoCT diagnostic methodology may provide a way of stratifying risk groups, deciding upon referrals, and in the institution of diligent oral hygiene regimens.", "doi": "10.1002/cre2.589", "pmid": "35818743", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9350191"}], "notes": [], "created": "2022-08-17T10:38:13.639Z", "modified": "2022-08-17T10:38:13.684Z"}, {"entity": "publication", "iuid": "d1eb92db423247949c9d1e0866bfded6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1eb92db423247949c9d1e0866bfded6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1eb92db423247949c9d1e0866bfded6"}}, "title": "SARS-COV-2 a trigger of myelin oligodendrocyte glycoprotein-associated disorder.", "authors": [{"family": "Johnsson", "given": "Magnus", "initials": "M", "orcid": "0000-0001-7151-201X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6bef027f84b48efa6d645d3ce116414.json"}}, {"family": "Asztely", "given": "Fredrik", "initials": "F"}, {"family": "Hejnebo", "given": "Susanne", "initials": "S"}, {"family": "Axelsson", "given": "Markus", "initials": "M"}, {"family": "Malmestr\u00f6m", "given": "Clas", "initials": "C", "orcid": "0000-0003-2477-0088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1de3045467364de388c62f23a8a4e171.json"}}, {"family": "Olausson", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Lycke", "given": "Jan", "initials": "J", "orcid": "0000-0002-7891-8466", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/95ab980b7e15438f94f49826d1c4487a.json"}}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Ann Clin Transl Neurol", "issn": "2328-9503", "volume": "9", "issue": "8", "pages": "1296-1301", "issn-l": "2328-9503"}, "abstract": "SARS-COV-2 frequently cause neurological disorders and is sometimes associated with onset of autoimmune diseases affecting the nervous system. Over recent years, a rare but distinct diagnosis designated myelin oligodendrocyte glycoprotein-associated disorder (MOGAD) has been recognized in patients with attacks of optic neuritis, myelitis, or encephalomyelitis and increased levels of anti-MOG antibodies. The cause of MOGAD is unknown. However, there have been reports of single cases of MOGAD in patients with Covid-19 infection. We report a series of SARS-CoV-2 positive patients that developed MOGAD, but a homology search did not support a cross-reactive immune response to SARS-CoV-2 spike-protein and MOG.", "doi": "10.1002/acn3.51609", "pmid": "35713508", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9349599"}], "notes": [], "created": "2022-06-20T18:05:43.774Z", "modified": "2022-08-17T12:46:46.703Z"}, {"entity": "publication", "iuid": "2805ba660c7c40539470a6f03e67b32d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2805ba660c7c40539470a6f03e67b32d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2805ba660c7c40539470a6f03e67b32d"}}, "title": "Risk factors for multisystem inflammatory syndrome in children - A population-based cohort study of over 2 million children.", "authors": [{"family": "Rhedin", "given": "Samuel", "initials": "S"}, {"family": "Lundholm", "given": "Cecilia", "initials": "C"}, {"family": "Horne", "given": "AnnaCarin", "initials": "A"}, {"family": "Smew", "given": "Awad I", "initials": "AI"}, {"family": "Osvald", "given": "Emma Caffrey", "initials": "EC"}, {"family": "Haddadi", "given": "Araz", "initials": "A"}, {"family": "Alfv\u00e9n", "given": "Tobias", "initials": "T"}, {"family": "Kahn", "given": "Robin", "initials": "R"}, {"family": "Kr\u00f3l", "given": "Petra", "initials": "P"}, {"family": "Swedish Pediatric MIS-C Consortium", "given": "", "initials": ""}, {"family": "Brew", "given": "Bronwyn Haasdyk", "initials": "BH"}, {"family": "Almqvist", "given": "Catarina", "initials": "C"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "19", "pages": "100443", "issn-l": null}, "abstract": "Although severe acute COVID-19 is rare in children, SARS-CoV-2 infection can trigger the novel post-infectious condition multisystem inflammatory syndrome in children (MIS-C). Increased knowledge on risk factors for MIS-C could improve our understanding of the pathogenesis of the condition and better guide targeted public health interventions. The aim of the study was to assess risk factors for MIS-C with the aim to identify vulnerable children.\n\nA register-based cohort study including all children and adolescents <19 years born in Sweden between March 1, 2001- December 31, 2020 was performed. Data on sociodemographic risk factors and comorbidities (sex, age, parental region of birth, parental education, asthma, autoimmune disease, chromosomal anomalies, chronic heart disease, chronic lung disease, obesity, life-limiting condition) were retrieved from national health and population registers. The outcome was MIS-C diagnosis according to the Swedish Pediatric Rheumatology Quality Register during March 1, 2020 - December 8, 2021.Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox regression analysis. Incidence rates per 100 000 person-years were calculated assuming a Poisson distribution.\n\nAmong 2 117 443 children included in the study, 253 children developed MIS-C, corresponding to an incidence rate of 6\u00b78 (95% CI: 6\u00b70-7\u00b76) per 100 000 person-years. Male sex (HR 1\u00b765, 95% CI: 1\u00b728-2\u00b714), age 5-11 years (adjusted HR 1\u00b744, 95% CI: 1\u00b706-1\u00b795 using children 0-4 years as reference), foreign-born parents (HR 2\u00b753, 95% CI: 1\u00b793-3\u00b734), asthma (aHR 1\u00b749, 95% CI: 1\u00b700-2\u00b720), obesity (aHR 2\u00b715, 95% CI: 1\u00b709-4\u00b725) and life-limiting conditions (aHR 3\u00b710, 95% CI: 1\u00b780-5\u00b733) were associated with MIS-C. Children 16-18 years had a reduced risk for MIS-C (aHR 0\u00b745, 95% CI: 0\u00b724-0\u00b785).\n\nWe report increased risks for MIS-C in children with male sex, age 5-11 years, foreign-born parents, asthma, obesity, and life-limiting condition. Knowing these risk populations might facilitate identification of children with MIS-C and potentially guide targeted public health interventions. Nevertheless, the absolute risks for MIS-C were very low.\n\nFinancial support was provided from the Swedish Research Council (grant no 2018-02640), the Swedish Heart-Lung Foundation (grant no 20210416), the Asthma and Allergy Association, Ake Wiberg foundation, the Samariten Foundation, the Society of Child Care, and Region Stockholm.", "doi": "10.1016/j.lanepe.2022.100443", "pmid": "35945929", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(22)00137-5"}, {"db": "pmc", "key": "PMC9353212"}], "notes": [], "created": "2022-08-11T11:49:13.500Z", "modified": "2022-08-11T11:49:13.513Z"}, {"entity": "publication", "iuid": "00a60a53400d4140af4f0c1811e60055", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/00a60a53400d4140af4f0c1811e60055.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/00a60a53400d4140af4f0c1811e60055"}}, "title": "Public health, surveillance policies and actions to prevent community spread of COVID-19 in Denmark, Serbia and Sweden.", "authors": [{"family": "Andersen", "given": "Pernille Tanggaard", "initials": "PT", "orcid": "0000-0001-7334-761X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7af3f08a7c14f0f957525c519bd228f.json"}}, {"family": "Loncarevic", "given": "Natasa", "initials": "N"}, {"family": "Damgaard", "given": "Maria Busk", "initials": "MB"}, {"family": "Jacobsen", "given": "Mette Winge", "initials": "MW"}, {"family": "Bassioni-Stamenic", "given": "Farida", "initials": "F"}, {"family": "Eklund Karlsson", "given": "Leena", "initials": "L", "orcid": "0000-0003-2052-0989", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8ef669769e44be2abff29ee81474c49.json"}}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "711-729", "volume": "50", "issue": "6", "issn-l": "1403-4948"}, "abstract": "Aim: This study investigates the non-medical public health and surveillance policies and actions for tackling the community spread of COVID-19 pandemic in Denmark, Serbia and Sweden during the first five months of the pandemic in 2020. Method: The study is inspired by a process-tracing design for case study with a focus on the non-medical measures and surveillance strategies implemented by the three countries. The comprehensive collection and study of national documents formed the basis of the document analysis. Results: The Danish strategy was to prolong the transmission period, preventing high numbers of infected cases from impacting their healthcare capacity. The government's strategy was characterized by strict governance elements, health guidelines and behavioural recommendations. In Serbia, the main strategy was to prevent the spread and control of the infectious disease by shifting all human and material resources towards the function of controlling the spread. Serbia applied the strictest measures in the fight against coronavirus in relation to other countries in the region and in Europe. The Swedish strategy focused more on recommendations than requirements to motivate the public to modify their behaviours voluntarily. Sweden's loose pandemic strategy implementation focused on voluntary and stepwise action rather than legislation and compulsory measures. Conclusions:The public health policies and actions implemented to prevent community spread of COVID-19 in Denmark, Serbia and Sweden varied during the first five months of the pandemic. The differences in their response were due to delays in implementation, inconsistencies in perspectives towards the outbreak and the capacity of each country in terms of their pandemic preparedness and response.", "doi": "10.1177/14034948211056215", "pmid": "34844483", "labels": {"Type: Review": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T18:10:53.356Z", "modified": "2023-01-13T14:46:19.134Z"}, {"entity": "publication", "iuid": "43eb008807304184af3e179e29e7898e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/43eb008807304184af3e179e29e7898e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/43eb008807304184af3e179e29e7898e"}}, "title": "Outcome of infection with omicron SARS-CoV-2 variant in patients with hematological malignancies: An EPICOVIDEHA survey report.", "authors": [{"family": "Blennow", "given": "Ola", "initials": "O", "orcid": "0000-0002-7167-7882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2318c3973e66443aa14fceca0908d127.json"}}, {"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J", "orcid": "0000-0002-6766-8297", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dea501020d2042ad83d1b024987792f4.json"}}, {"family": "Nowak", "given": "Piotr", "initials": "P", "orcid": "0000-0003-2747-0734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1d81fdccf9e424fa99ea5227b031843.json"}}, {"family": "Itri", "given": "Federico", "initials": "F", "orcid": "0000-0002-3532-5281", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98feda63fd134739ab222629acdc3e46.json"}}, {"family": "Van Doesum", "given": "Jaap", "initials": "J", "orcid": "0000-0003-0214-3219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49152311cb004139904554d1c096c05c.json"}}, {"family": "L\u00f3pez-Garc\u00eda", "given": "Alberto", "initials": "A", "orcid": "0000-0002-5354-5261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c785356a67e4cbb9835fe9ce04a6153.json"}}, {"family": "Farina", "given": "Francesca", "initials": "F", "orcid": "0000-0002-5124-6970", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06ead8985bd241ee814a94a6186bb898.json"}}, {"family": "Jaksic", "given": "Ozren", "initials": "O", "orcid": "0000-0003-4026-285X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/359a2798d30a4a5aa03f587bfb87322f.json"}}, {"family": "Pincz\u00e9s", "given": "L\u00e1szl\u00f3 Imre", "initials": "LI", "orcid": "0000-0003-0453-1709", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed1924c856a44492a74f02654b53ca61.json"}}, {"family": "Bilgin", "given": "Yavuz M", "initials": "YM", "orcid": "0000-0002-3783-3407", "researcher": {"href": 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"Rebeca", "initials": "R", "orcid": "0000-0003-2838-1776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d185c2be2bd4d8b9929a1812ae9d327.json"}}, {"family": "Hoenigl", "given": "Martin", "initials": "M", "orcid": "0000-0002-1653-2824", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f06a81d02454972bb9b64fea7c14dd4.json"}}, {"family": "Dragonetti", "given": "Giulia", "initials": "G", "orcid": "0000-0003-1775-6333", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81694822ac4d4074bfabe757d03f5f9e.json"}}, {"family": "Chai", "given": "Louis Yi Ann", "initials": "LYA"}, {"family": "Kho", "given": "Chi Shan", "initials": "CS"}, {"family": "Bonanni", "given": "Matteo", "initials": "M"}, {"family": "Li\u00e9vin", "given": "Rapha\u00ebl", "initials": "R", "orcid": "0000-0002-5097-591X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d190434cf5f428f9714a761a1b67889.json"}}, {"family": "Marchesi", "given": "Francesco", "initials": "F", "orcid": "0000-0001-6353-2272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e09d8d1e4eb498781444b8d095687a0.json"}}, {"family": "Cornely", "given": "Oliver A", "initials": "OA", "orcid": "0000-0001-9599-3137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3c62d8346924e69b6c99e4007c3831c.json"}}, {"family": "Pagano", "given": "Livio", "initials": "L", "orcid": "0000-0001-8287-928X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbf92a9779614910aeafcc6c21d880e2.json"}}], "type": "letter", "published": "2022-08-00", "journal": {"title": "Am J Hematol", "issn": "0361-8609", "issn-l": null, "volume": "97", "issue": "8", "pages": "E312-E317"}, "abstract": null, "doi": "10.1002/ajh.26626", "pmid": "35702878", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9349555"}], "notes": [], "created": "2022-06-20T18:12:52.201Z", "modified": "2022-08-17T13:00:29.008Z"}, {"entity": "publication", "iuid": "419c229086fc4e749e9c98b961bac8fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/419c229086fc4e749e9c98b961bac8fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/419c229086fc4e749e9c98b961bac8fc"}}, "title": "Monoclonal antibodies binding data for SARS-CoV-2 proteins.", "authors": [{"family": "Mishra", "given": "Nawneet", "initials": "N"}, {"family": "Teyra", "given": "Joan", "initials": "J"}, {"family": "Boytz", "given": "RuthMabel", "initials": "R"}, {"family": "Miersch", "given": "Shane", "initials": "S"}, {"family": "Merritt", "given": "Trudy N", "initials": "TN"}, {"family": "Cardarelli", "given": "Lia", "initials": "L"}, {"family": "Gorelik", "given": "Maryna", "initials": "M"}, {"family": "Mihalic", "given": "Filip", "initials": "F"}, {"family": "Jemth", "given": "Per", "initials": "P"}, {"family": "Davey", "given": "Robert A", "initials": "RA"}, {"family": "Sidhu", "given": "Sachdev S", "initials": "SS"}, {"family": "Leung", "given": "Daisy W", "initials": "DW"}, {"family": "Amarasinghe", "given": "Gaya K", "initials": "GK"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Data Brief", "issn": "2352-3409", "volume": "43", "pages": "108415", "issn-l": null}, "abstract": "SARS-CoV-2 pandemic opens up the curiosity of understanding the coronavirus. This demand for the development of the regent, which can be used for academic and therapeutic applications. The present data provide the biochemical characterization of synthetically developed monoclonal antibodies for the SARS-CoV-2 proteins. The antibodies from phage-displayed antibody libraries were selected with the SARS-CoV-2 proteins immobilized in microwell plates. The clones which bind to the antigen in Fab-phage ELISA were selected, and a two-point competitive phage ELISA was performed. Antibodies binding kinetic of IgGs for SARS-CoV2 proteins further carried with B.L.I. Systematic analysis of binding with different control proteins and purified SARS-CoV-2 ensured the robustness of the antibodies.", "doi": "10.1016/j.dib.2022.108415", "pmid": "35789908", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9232259"}, {"db": "pii", "key": "S2352-3409(22)00612-6"}], "notes": [], "created": "2022-08-17T13:08:36.040Z", "modified": "2023-06-19T15:05:48.083Z"}, {"entity": "publication", "iuid": "b8e48b55409345ff8cabbd0a928ab919", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8e48b55409345ff8cabbd0a928ab919.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8e48b55409345ff8cabbd0a928ab919"}}, "title": "Milder disease trajectory among COVID-19 patients hospitalised with the SARS-CoV-2 Omicron variant compared with the Delta variant in Norway.", "authors": [{"family": "St\u00e5lcrantz", "given": "Jeanette", "initials": "J", "orcid": "0000-0001-8086-4244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e6220d843754651b919cae3e687d3d5.json"}}, {"family": "Kristoffersen", "given": "Anja Br\u00e5then", "initials": "AB"}, {"family": "B\u00f8\u00e5s", "given": "H\u00e5kon", "initials": "H", "orcid": "0000-0002-5917-1563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9cc00f104cd64e53ab58eebd46368861.json"}}, {"family": "Veneti", "given": "Lamprini", "initials": "L"}, {"family": "Sepp\u00e4l\u00e4", "given": "Elina", "initials": "E"}, {"family": "Aasand", "given": "Nina", "initials": "N"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "Kv\u00e5le", "given": "Reidar", "initials": "R"}, {"family": "Bragstad", "given": "Karoline", "initials": "K"}, {"family": "Buanes", "given": "Eirik Alnes", "initials": "EA"}, {"family": "Whittaker", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "volume": "50", "issue": "6", "pages": "676-682", "issn-l": "1403-4948"}, "abstract": "Using individual-level national registry data, we conducted a cohort study to estimate differences in the length of hospital stay, and risk of admission to an intensive care unit and in-hospital death among patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant, compared with patients infected with Delta variant in Norway. We included 409 (38%) patients infected with Omicron and 666 (62%) infected with Delta who were hospitalised with coronavirus disease 2019 (COVID-19) as the main cause of hospitalisation between 6 December 2021 and 6 February 2022. Omicron patients had a 48% lower risk of intensive care admission (adjusted hazard ratios (aHR): 0.52, 95% confidence interval (CI): 0.34-0.80) and a 56% lower risk of in-hospital death (aHR: 0.44, 95%CI: 0.24-0.79) compared with Delta patients. Omicron patients had a shorter length of stay (with or without ICU stay) compared with Delta patients in the age groups from 18 to 79 years and those who had at least completed their primary vaccination. This supports growing evidence of reduced disease severity among hospitalised Omicron patients compared with Delta patients.", "doi": "10.1177/14034948221108548", "pmid": "35799474", "labels": {"Category: Omicron VoC": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-17T10:45:15.917Z", "modified": "2022-08-17T10:45:16.004Z"}, {"entity": "publication", "iuid": "d2cf9578d52c495ca762c0a8332d614c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d2cf9578d52c495ca762c0a8332d614c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d2cf9578d52c495ca762c0a8332d614c"}}, "title": "Lessons from the IMPAACT of coronavirus disease 2019 public health restrictions on food allergy-associated anxiety.", "authors": [{"family": "Golding", "given": "Michael A", "initials": "MA"}, {"family": "Protudjer", "given": "Jennifer L P", "initials": "JLP"}], "type": "editorial", "published": "2022-08-00", "journal": {"title": "Ann Allergy Asthma Immunol", "issn": "1534-4436", "volume": "129", "issue": "2", "pages": "134-135", "issn-l": null}, "abstract": null, "doi": "10.1016/j.anai.2022.05.018", "pmid": "35878957", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1081-1206(22)00450-1"}], "notes": [], "created": "2022-08-12T08:39:02.556Z", "modified": "2022-08-12T08:39:02.586Z"}, {"entity": "publication", "iuid": "1c6630c4d7dc433d982ba605747c9041", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1c6630c4d7dc433d982ba605747c9041.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1c6630c4d7dc433d982ba605747c9041"}}, "title": "Income differences in COVID-19 incidence and severity in Finland among people with foreign and native background: A population-based cohort study of individuals nested within households.", "authors": [{"family": "Saarinen", "given": "Sanni", "initials": "S", "orcid": "0000-0002-4866-002X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/311a9e98129c432782f7e893757c60a1.json"}}, {"family": "Moustgaard", "given": "Heta", "initials": "H"}, {"family": "Remes", "given": "Hanna", "initials": "H", "orcid": "0000-0002-9291-703X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cbdeb824ba154b5595275b2275e32568.json"}}, {"family": "Sallinen", "given": "Riikka", "initials": "R"}, {"family": "Martikainen", "given": "Pekka", "initials": "P", "orcid": "0000-0001-9374-1438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc740067d77b4773826c66c9eddc6827.json"}}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "PLoS Med", "issn": "1549-1676", "volume": "19", "issue": "8", "pages": "e1004038", "issn-l": "1549-1277"}, "abstract": "Although intrahousehold transmission is a key source of Coronavirus Disease 2019 (COVID-19) infections, studies to date have not analysed socioeconomic risk factors on the household level or household clustering of severe COVID-19. We quantify household income differences and household clustering of COVID-19 incidence and severity.\n\nWe used register-based cohort data with individual-level linkage across various administrative registers for the total Finnish population living in working-age private households (N = 4,315,342). Incident COVID-19 cases (N = 38,467) were identified from the National Infectious Diseases Register from 1 July 2020 to 22 February 2021. Severe cases (N = 625) were defined as having at least 3 consecutive days of inpatient care with a COVID-19 diagnosis and identified from the Care Register for Health Care between 1 July 2020 and 31 December 2020. We used 2-level logistic regression with individuals nested within households to estimate COVID-19 incidence and case severity among those infected. Adjusted for age, sex, and regional characteristics, the incidence of COVID-19 was higher (odds ratio [OR] 1.67, 95% CI 1.58 to 1.77, p < 0.001, 28.4% of infections) among individuals in the lowest household income quintile than among those in the highest quintile (18.9%). The difference attenuated (OR 1.23, 1.16 to 1.30, p < 0.001) when controlling for foreign background but not when controlling for other household-level risk factors. In fact, we found a clear income gradient in incidence only among people with foreign background but none among those with native background. The odds of severe illness among those infected were also higher in the lowest income quintile (OR 1.97, 1.52 to 2.56, p < 0.001, 28.0% versus 21.6% in the highest quintile), but this difference was fully attenuated (OR 1.08, 0.77 to 1.52, p = 0.64) when controlling for other individual-level risk factors-comorbidities, occupational status, and foreign background. Both incidence and severity were strongly clustered within households: Around 77% of the variation in incidence and 20% in severity were attributable to differences between households. The main limitation of our study was that the test uptake for COVID-19 may have differed between population subgroups.\n\nLow household income appears to be a strong risk factor for both COVID-19 incidence and case severity, but the income differences are largely driven by having foreign background. The strong household clustering of incidence and severity highlights the importance of household context in the prevention and mitigation of COVID-19 outcomes.", "doi": "10.1371/journal.pmed.1004038", "pmid": "35947575", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PMEDICINE-D-21-04207"}], "notes": [], "created": "2022-08-11T11:47:22.362Z", "modified": "2022-08-12T08:30:09.536Z"}, {"entity": "publication", "iuid": "eb25df38bf974d95a90185675f983989", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb25df38bf974d95a90185675f983989.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb25df38bf974d95a90185675f983989"}}, "title": "Health care utilization and outcomes in older adults after Traumatic Brain Injury: A CENTER-TBI study.", "authors": [{"family": "van der Vlegel", "given": "Marjolein", "initials": "M"}, {"family": "Mikoli\u0107", "given": "Ana", "initials": "A"}, {"family": "Lee Hee", "given": "Quentin", "initials": "Q"}, {"family": "Kaplan", "given": "Z L Rana", "initials": "ZLR"}, {"family": "Retel Helmrich", "given": "Isabel R A", "initials": "IRA"}, {"family": "van Veen", "given": "Ernest", "initials": "E"}, {"family": "Andelic", "given": "Nada", "initials": "N"}, {"family": "Steinbuechel", "given": "Nicole V", "initials": "NV"}, {"family": "Plass", "given": "Anne Marie", "initials": "AM"}, {"family": "Zeldovich", "given": "Marina", "initials": "M"}, {"family": "Wilson", "given": "Lindsay", "initials": "L"}, {"family": "Maas", "given": "Andrew I R", "initials": "AIR"}, {"family": "Haagsma", "given": "Juanita A", "initials": "JA"}, {"family": "Polinder", "given": "Suzanne", "initials": "S"}, {"family": "CENTER-TBI Participants and Investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Injury", "issn": "1879-0267", "volume": "53", "issue": "8", "pages": "2774-2782", "issn-l": null}, "abstract": "The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged \u226565 years, forming a growing public health problem. However, older adults are underrepresented in TBI research. Therefore, we aimed to provide an overview of health-care utilization, and of six-month outcomes after TBI and their determinants in older adults who sustained a TBI.\n\nWe used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. In-hospital and post-hospital health care utilization and outcomes were described for patients aged \u226565 years. Ordinal and linear regression analyses were performed to identify determinants of the Glasgow Outcome Scale Extended (GOSE), health-related quality of life (HRQoL), and mental health symptoms six-months post-injury.\n\nOf 1254 older patients, 45% were admitted to an ICU with a mean length of stay of 9 days. Nearly 30% of the patients received inpatient rehabilitation. In total, 554/1254 older patients completed the six-month follow-up questionnaires. The mortality rate was 9% after mild and 60% after moderate/severe TBI, and full recovery based on GOSE was reported for 44% of patients after mild and 6% after moderate/severe TBI. Higher age and increased injury severity were primarily associated with functional impairment, while pre-injury systemic disease, psychiatric conditions and lower educational level were associated with functional impairment, lower generic and disease-specific HRQoL and mental health symptoms.\n\nThe rate of impairment and disability following TBI in older adults is substantial, and poorer outcomes across domains are associated with worse preinjury health. Nonetheless, a considerable number of patients fully or partially returns to their preinjury functioning. There should not be pessimism about outcomes in older adults who survive.", "doi": "10.1016/j.injury.2022.05.009", "pmid": "35725508", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0020-1383(22)00329-1"}], "notes": [], "created": "2022-08-17T13:04:27.837Z", "modified": "2022-08-17T13:04:27.864Z"}, {"entity": "publication", "iuid": "4a20c42bea8642c68d665eda819b9577", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4a20c42bea8642c68d665eda819b9577.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4a20c42bea8642c68d665eda819b9577"}}, "title": "Gaming and social media use among adolescents in the midst of the COVID-19 pandemic.", "authors": [{"family": "Nilsson", "given": "Anders", "initials": "A", "orcid": "0000-0002-0982-8483", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aaa310c68f1a475380fe60327e00405f.json"}}, {"family": "Rosendahl", "given": "Ingvar", "initials": "I", "orcid": "0000-0002-1325-913X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bbfd62b47d64bf1909cdc79d6d85054.json"}}, {"family": "Jayaram-Lindstr\u00f6m", "given": "Nitya", "initials": "N"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Nordisk Alkohol Nark", "issn": "1458-6126", "volume": "39", "issue": "4", "pages": "347-361", "issn-l": null}, "abstract": "Background and aims: The COVID-19 pandemic has dramatically changed life circumstances for adolescents worldwide. With schools being closed and regular activities being cancelled, gaming and social media use are activities that might gain in importance. There is a risk that these online behaviours have negative effects on other important activities, such as being physically active, sleeping, and studying, as well as general well-being. The aim of this study was to investigate the effects of the COVID-19 pandemic on gaming and social media use, and its effects on the well-being of adolescents. Methods: A total of 1232 adolescents (82.5% female) participated in an anonymous web survey containing questions on gaming, social media use, and perceived negative consequences of gaming and social media use during the COVID-19 pandemic. The results were analysed with a quasi-Poisson regression model. Results: The results indicated an increase in gaming and social media use, which was associated with negative consequences and perceived well-being. A majority of adolescents reported that they used social media more than they felt comfortable with. There were large differences between boys and girls, with girls being more negatively affected across measures. Discussion: The increase in gaming and social media use during the COVID-19 pandemic might have negative effects on the well-being of adolescents, and on other activities that are important to health. Our interpretation of the findings is that gaming and social media use might partly function as coping mechanisms to deal with stress and/or boredom resulting from COVID-19 restrictions. There is a risk that these coping strategies become maladaptive over time. Conclusions: The restrictions from the COVID-19 pandemic have resulted in an increase in the amount of time adolescents spend gaming and on social media, which might have negative effects on their well-being. This study highlights the urgent need to consider adaptive and healthy coping strategies for adolescents given the pandemic may mean that daily living could continue to be altered in the near future.", "doi": "10.1177/14550725221074997", "pmid": "35999947", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1177_14550725221074997"}, {"db": "pmc", "key": "PMC8819558"}], "notes": [], "created": "2022-08-26T04:44:06.685Z", "modified": "2022-08-26T04:44:06.799Z"}, {"entity": "publication", "iuid": "c43b69e1fdf14da28e0eb4ba5b79d1a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c43b69e1fdf14da28e0eb4ba5b79d1a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c43b69e1fdf14da28e0eb4ba5b79d1a4"}}, "title": "Epigenetic mechanisms regulate sex-specific bias in disease manifestations.", "authors": [{"family": "Chlamydas", "given": "Sarantis", "initials": "S"}, {"family": "Markouli", "given": "Mariam", "initials": "M"}, {"family": "Strepkos", "given": "Dimitrios", "initials": "D"}, {"family": "Piperi", "given": "Christina", "initials": "C", "orcid": "0000-0002-2701-0618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15e4ce9ec9754a6b881eaaa8d1de3c17.json"}}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "J Mol Med (Berl)", "issn": "1432-1440", "volume": "100", "issue": "8", "pages": "1111-1123", "issn-l": null}, "abstract": "Sex presents a vital determinant of a person's physiology, anatomy, and development. Recent clinical studies indicate that sex is also involved in the differential manifestation of various diseases, affecting both clinical outcome as well as response to therapy. Genetic and epigenetic changes are implicated in sex bias and regulate disease onset, including the inactivation of the X chromosome as well as sex chromosome aneuploidy. The differential expression of X-linked genes, along with the presence of sex-specific hormones, exhibits a significant impact on immune system function. Several studies have revealed differences between the two sexes in response to infections, including respiratory diseases and COVID-19 infection, autoimmune disorders, liver fibrosis, neuropsychiatric diseases, and cancer susceptibility, which can be explained by sex-biased immune responses. In the present review, we explore the input of genetic and epigenetic interplay in the sex bias underlying disease manifestation and discuss their effects along with sex hormones on disease development and progression, aiming to reveal potential new therapeutic targets. KEY MESSAGES: Sex is involved in the differential manifestation of various diseases. Epigenetic modifications influence X-linked gene expression, affecting immune response to infections, including COVID-19. Epigenetic mechanisms are responsible for the sex bias observed in several respiratory and autoimmune disorders, liver fibrosis, neuropsychiatric diseases, and cancer.", "doi": "10.1007/s00109-022-02227-x", "pmid": "35764820", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00109-022-02227-x"}, {"db": "pmc", "key": "PMC9244100"}], "notes": [], "created": "2022-08-19T05:34:12.520Z", "modified": "2022-08-19T05:34:22.233Z"}, {"entity": "publication", "iuid": "c3deb4b2a368402997300e196e67df11", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3deb4b2a368402997300e196e67df11.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3deb4b2a368402997300e196e67df11"}}, "title": "Corrigendum. Re: de Sousa, N.R., et al., 2022. Detection and isolation of airborne SARS-CoV-2 in a hospital setting. Indoor air, 32(3), e13023.", "authors": [{"family": "Rufino de Sousa", "given": "Nuno", "initials": "N", "orcid": "0000-0002-0670-9788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1cb037a9e7f44a489dd84d6f5ba513d7.json"}}, {"family": "Steponaviciute", "given": "Laura", "initials": "L"}, {"family": "Margerie", "given": "Lucille", "initials": "L", "orcid": "0000-0001-9537-1231", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e7015e5251242ecb70df112f997182b.json"}}, {"family": "Nissen", "given": "Karolina", "initials": "K"}, {"family": "Kjellin", "given": "Midori", "initials": "M", "orcid": "0000-0002-1377-6014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cbf761ec44641a5a70ee1b8f7964a20.json"}}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Salaneck", "given": "Erik", "initials": "E"}, {"family": "Udekwu", "given": "Klas I", "initials": "KI"}, {"family": "Rothfuchs", "given": "Antonio Gigliotti", "initials": "AG", "orcid": "0000-0001-6001-7240", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00102c49ae2d41828272e850cd551c9f.json"}}], "type": "letter", "published": "2022-08-00", "journal": {"title": "Indoor Air", "issn": "0905-6947", "volume": "32", "issue": "8", "pages": "e13085", "issn-l": null}, "abstract": null, "doi": "10.1111/ina.13085", "pmid": "36040276", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-10-07T12:50:16.510Z", "modified": "2022-10-07T12:51:48.911Z"}, {"entity": "publication", "iuid": "e7c6cac338774bdd8fc521b6eaadba9b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e7c6cac338774bdd8fc521b6eaadba9b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e7c6cac338774bdd8fc521b6eaadba9b"}}, "title": "Changes in mortality trends amongst common diseases during the COVID-19 pandemic in Sweden.", "authors": [{"family": "Axenhus", "given": "Michael", "initials": "M", "orcid": "0000-0002-2476-4465", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c8ec5de3a68400981b1caa3e5260828.json"}}, {"family": "Schedin-Weiss", "given": "Sophia", "initials": "S"}, {"family": "Winblad", "given": "Bengt", "initials": "B"}, {"family": "Wimo", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "748-755", "volume": "50", "issue": "6", "issn-l": "1403-4948"}, "abstract": "It has been found that COVID-19 increases deaths within common diseases in countries that have implemented strict lockdowns. In order to elucidate the proper national response to a pandemic, the mortality rates within COVID-19 and various diseases need to be studied in countries whose pandemic response differ. Sweden represents a country with lax pandemic restrictions, and we aimed to study the effects of COVID-19 on historical mortality rates within common diseases during 2020.\n\nRegression models and moving averages were used to predict expected premature mortality per the ICD-10 during 2020 using historical data sets. Predicted values were then compared to recorded premature mortality to identify changes in mortality trends.\n\nSeasonal increased mortality was found within neurological diseases. Infectious diseases, tumours and cardiac disease mortality rates decreased compared to expected outcome.\n\nChanges in mortality trends were observed for several common diseases during the COVID-19 pandemic. Neurological and cardiac conditions, infections and tumours are examples of diseases that were heavily affected by the pandemic. The indirect effects of COVID-19 on certain patient populations should be considered when determining pandemic impact.", "doi": "10.1177/14034948211064656", "pmid": "34933630", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9361422"}], "notes": [], "created": "2022-01-03T15:31:10.078Z", "modified": "2023-01-13T13:36:55.994Z"}, {"entity": "publication", "iuid": "0a372b79beb64fd8a99d8cb5ca649254", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a372b79beb64fd8a99d8cb5ca649254.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a372b79beb64fd8a99d8cb5ca649254"}}, "title": "COVID-19 vaccine hesitancy in Sweden and Italy: The role of trust in authorities.", "authors": [{"family": "Raffetti", "given": "Elena", "initials": "E", "orcid": "0000-0001-8742-3986", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49139fd67cc4feb9e68942e70eecd92.json"}}, {"family": "Mondino", "given": "Elena", "initials": "E"}, {"family": "Di Baldassarre", "given": "Giuliano", "initials": "G"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "803-809", "volume": "50", "issue": "6", "issn-l": "1403-4948"}, "abstract": "The success of vaccination campaigns against COVID-19 infection is vital for moving from a COVID-19 pandemic to an endemic scenario. We aimed to unravel the influence of the risk perception of epidemics along with individual and contextual factors on adherence to COVID-19 vaccination campaigns in Italy and Sweden.\n\nWe compared the results of two nationwide surveys carried out in August 2021 across four domains of epidemic risk perception: perceived likelihood, perceived impact on the individual and perceived individual and authority knowledge. The roles of individual and contextual determinants were also explored.\n\nThe survey included 2144 participants in Sweden (52.3% women) and 2010 in Italy (52.6% women). In both countries, we found that trust in authorities was one of the main drivers of this process, with two-fold increased odds of being vaccinated. Being highly educated and having a higher relative income were associated with a higher adherence to the vaccination campaign (for relative income OR = 1.44, 95% CI 1.23-1.67 in Sweden and OR = 1.18, 95% CI 1.04-1.34 in Italy; for education OR = 1.90, 95% CI 1.30-2.77 in Sweden and OR = 1.47, 95% CI 1.09-1.97 in Italy), whereas a right and centre-right compared with a left and centre-left political orientation was negatively related to vaccination adherence (OR = 0.41, 95% CI 0.25-0.67 in Sweden and OR = 0.47, 95% CI 0.33-0.68 in Italy).\n\nIncreasing trust in authorities, along with an equal global distribution of vaccine doses, can contribute to accelerating vaccination campaigns around the world and, in turn, to move towards an endemic scenario.", "doi": "10.1177/14034948221099410", "pmid": "35656576", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9361415"}], "notes": [], "created": "2022-06-21T17:19:26.872Z", "modified": "2023-01-13T13:26:46.332Z"}, {"entity": "publication", "iuid": "2d8688815a6f4c68bbb3feddac31eff3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d8688815a6f4c68bbb3feddac31eff3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d8688815a6f4c68bbb3feddac31eff3"}}, "title": "COVID vaccination in older adults.", "authors": [{"family": "H\u00e4gg", "given": "Sara", "initials": "S", "orcid": "0000-0002-2452-1500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f65e8028f3a0410099f7dfdbfa79ca42.json"}}, {"family": "Religa", "given": "Dorota", "initials": "D"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Nat Microbiol", "issn": "2058-5276", "volume": "7", "issue": "8", "pages": "1106-1107", "issn-l": null}, "abstract": null, "doi": "10.1038/s41564-022-01166-0", "pmid": "35836001", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41564-022-01166-0"}], "notes": [], "created": "2022-08-12T09:00:47.401Z", "modified": "2022-08-12T09:00:47.457Z"}, {"entity": "publication", "iuid": "9708437ef73e44eda9a26129ec65469d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9708437ef73e44eda9a26129ec65469d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9708437ef73e44eda9a26129ec65469d"}}, "title": "Autoantibodies in COVID-19 correlate with antiviral humoral responses and distinct immune signatures.", "authors": [{"family": "Taeschler", "given": "Patrick", "initials": "P", "orcid": "0000-0003-0522-7629", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b070a1c2cd840849b9e8ce333068867.json"}}, {"family": "Cervia", "given": "Carlo", "initials": "C", "orcid": "0000-0001-7120-8739", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d0c8b0ac68984748ae12d25bf50fdb5d.json"}}, {"family": "Zurbuchen", "given": "Yves", "initials": "Y", "orcid": "0000-0001-5387-9950", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33558ac87673432f8fa00ecad5b9ff6d.json"}}, {"family": "Hasler", "given": "Sara", "initials": "S", "orcid": "0000-0001-7357-9090", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c600e18dbb448dd91b895bb1c380e0f.json"}}, {"family": "Pou", "given": "Christian", "initials": "C", "orcid": "0000-0003-3932-788X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c43110c557a448a58782ba750b5be26e.json"}}, {"family": "Tan", "given": "Ziyang", "initials": "Z", "orcid": "0000-0002-7205-4978", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c593f081713402cac6296f48bffad51.json"}}, {"family": "Adamo", "given": "Sarah", "initials": "S", "orcid": "0000-0002-6161-3156", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01e7ff62bef7421fac217fab2707ed80.json"}}, {"family": "Raeber", "given": "Miro E", "initials": "ME", "orcid": "0000-0003-2609-0246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a14abc410a94f70987ac309368db2c7.json"}}, {"family": "B\u00e4chli", "given": "Esther", "initials": "E", "orcid": "0000-0003-4887-7576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e861fa430c4243e484b8ba62da346f4b.json"}}, {"family": "Rudiger", "given": "Alain", "initials": "A", "orcid": "0000-0001-7943-7624", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d62bfa03c7a41c9905ea62b34b65ee4.json"}}, {"family": "St\u00fcssi-Helbling", "given": "Melina", "initials": "M", "orcid": "0000-0002-7896-6644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0551149ea92e46d8892abc22c8767683.json"}}, {"family": "Huber", "given": "Lars C", "initials": "LC", "orcid": "0000-0001-5378-4716", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bdd38ab4a3ef45cfacdbfb756d794b9f.json"}}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}, {"family": "Nilsson", "given": "Jakob", "initials": "J", "orcid": "0000-0001-5091-8133", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9289345dc02f4457934c6d2771d5fec4.json"}}, {"family": "Probst-M\u00fcller", "given": "Elsbeth", "initials": "E", "orcid": "0000-0002-9046-4196", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d21e67609d84d13a973f89620b68247.json"}}, {"family": "Boyman", "given": "Onur", "initials": "O", "orcid": "0000-0001-8279-5545", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fd89e300ecc4a2b8d4e31f4d85eef8f.json"}}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": "77", "issue": "8", "pages": "2415-2430", "issn-l": "0105-4538"}, "abstract": "Several autoimmune features occur during coronavirus disease 2019 (COVID-19), with possible implications for disease course, immunity, and autoimmune pathology. In this study, we longitudinally screened for clinically relevant systemic autoantibodies to assess their prevalence, temporal trajectory, and association with immunity, comorbidities, and severity of COVID-19.\n\nWe performed highly sensitive indirect immunofluorescence assays to detect antinuclear antibodies (ANA) and antineutrophil cytoplasmic antibodies (ANCA), along with serum proteomics and virome-wide serological profiling in a multicentric cohort of 175 COVID-19 patients followed up to 1 year after infection, eleven vaccinated individuals, and 41 unexposed controls.\n\nCompared with healthy controls, similar prevalence and patterns of ANA were present in patients during acute COVID-19 and recovery. However, the paired analysis revealed a subgroup of patients with transient presence of certain ANA patterns during acute COVID-19. Furthermore, patients with severe COVID-19 exhibited a high prevalence of ANCA during acute disease. These autoantibodies were quantitatively associated with higher SARS-CoV-2-specific antibody titers in COVID-19 patients and in vaccinated individuals, thus linking autoantibody production to increased antigen-specific humoral responses. Notably, the qualitative breadth of antibodies cross-reactive with other coronaviruses was comparable in ANA-positive and ANA-negative individuals during acute COVID-19. In autoantibody-positive patients, multiparametric characterization demonstrated an inflammatory signature during acute COVID-19 and alterations of the B-cell compartment after recovery.\n\nHighly sensitive indirect immunofluorescence assays revealed transient autoantibody production during acute SARS-CoV-2 infection, while the presence of autoantibodies in COVID-19 patients correlated with increased antiviral humoral immune responses and inflammatory immune signatures.", "doi": "10.1111/all.15302", "pmid": "35364615", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9111424"}], "notes": [], "created": "2022-04-04T06:25:29.101Z", "modified": "2022-08-15T13:03:48.444Z"}, {"entity": "publication", "iuid": "eb05c45ac6734422a5c7c047326fc9a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb05c45ac6734422a5c7c047326fc9a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb05c45ac6734422a5c7c047326fc9a0"}}, "title": "A Cohort Study on Influenza Vaccine and All-Cause Mortality in Older Adults: Methodological Concerns and Public Health Implications.", "authors": [{"family": "Lapi", "given": "Francesco", "initials": "F", "orcid": "0000-0002-4342-9128", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06d5cef5638245d598c8c5ae1a514c33.json"}}, {"family": "Marconi", "given": "Ettore", "initials": "E"}, {"family": "Gualano", "given": "Maria Rosaria", "initials": "MR"}, {"family": "Vetrano", "given": "Davide Liborio", "initials": "DL"}, {"family": "Grattagliano", "given": "Ignazio", "initials": "I"}, {"family": "Rossi", "given": "Alessandro", "initials": "A"}, {"family": "Cricelli", "given": "Claudio", "initials": "C"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Drugs Aging", "issn": "1179-1969", "volume": "39", "issue": "8", "pages": "645-656", "issn-l": null}, "abstract": "In 2020, the restrictions adopted to control the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic led to an unprecedented reduction in influenza-related burden. As such, the reduced chance to characterize the circulating virus strains might have increased the risk of vaccine mismatch for the forthcoming winter seasons. The role of an effective influenza vaccination campaign might therefore assume even more value, especially for frail and multimorbid older individuals. Methodological concerns on confounding by indication are always debated in vaccine effectiveness studies and it might be instrumental to give a pragmatic message on an individual's responsibility to receive the influenza vaccine. We therefore investigated the role of specific confounders to explain the association between influenza vaccine and mortality among older adults.\n\nUsing a primary care database, we formed a cohort of patients aged 65 years or older who were actively registered with their general practitioner (GP) at the beginning of each of nine influenza seasons through to the 2018/2019 season. The study index date was the related seasons' starting date. Exposure to the influenza vaccine was operationally defined in the 2 months preceding the index date up to 2 weeks before the exit date. Cox regression models were estimated to calculate hazard ratios (HRs) and their 95% confidence intervals (CI) of death between vaccinated and unvaccinated patients in a time-dependent fashion. The potential confounders sequentially entered the model based on their increasing effect size observed in univariate analyses.\n\nOver the 10 years under study, the influenza vaccine showed a significant protective effect in terms of mortality, reaching 13% reduction (HR 0.87, 95% CI 0.80-0.95) in the 2018/2019 influenza season. When we estimated the multivariate model by sequentially adding the potential confounders, there was an inversion of HR (below the unit) that was significantly explained by the covariates coding for a prior history of lower respiratory tract infections and the presence of the pneumococcal vaccine.\n\nIn the current pandemic scenario, we cannot divert attention to proper use of face masks, social distancing, and hand hygiene, which are important measures to prevent influenza and other respiratory viral infections. Nonetheless, their effectiveness might be negligible without acceptable coverage for influenza vaccine, especially in older patients with a history of lower respiratory tract infections, which appears to be the main source of confounding by indication.", "doi": "10.1007/s40266-022-00958-7", "pmid": "35867212", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9305032"}, {"db": "pii", "key": "10.1007/s40266-022-00958-7"}], "notes": [], "created": "2022-08-12T08:41:43.205Z", "modified": "2023-06-19T15:30:14.102Z"}, {"entity": "publication", "iuid": "a5692e6b107c42baa428115a1abe000a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a5692e6b107c42baa428115a1abe000a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a5692e6b107c42baa428115a1abe000a"}}, "title": "Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework.", "authors": [{"family": "Clerbaux", "given": "Laure-Alix", "initials": "LA", "orcid": "0000-0003-2707-482X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/939248df1b6a46f38a59237a7b2f75dc.json"}}, {"family": "Albertini", "given": "Maria Cristina", "initials": "MC", "orcid": "0000-0003-4549-1475", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b634e74e14b45e5a0b9e9a36213a0a6.json"}}, {"family": "Amig\u00f3", "given": "N\u00faria", "initials": "N", "orcid": "0000-0002-0116-9145", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4d33dc1cbc84a7ba793dcc6db571cd2.json"}}, {"family": "Beronius", "given": "Anna", "initials": "A", "orcid": "0000-0001-9494-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9dd1a7937ff842d3943b11b4c3459f6e.json"}}, {"family": "Bezemer", "given": "Gillina F G", "initials": "GFG"}, {"family": "Coecke", "given": "Sandra", "initials": "S"}, {"family": "Daskalopoulos", "given": "Evangelos P", "initials": "EP"}, {"family": "Del Giudice", "given": "Giusy", "initials": "G"}, {"family": "Greco", "given": "Dario", "initials": "D", "orcid": "0000-0001-9195-9003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a1b8426cfa14677bf4f48740868c9a8.json"}}, {"family": "Grenga", "given": "Lucia", "initials": "L", "orcid": "0000-0001-5560-1717", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db628fe93ed94326869e52a86a47220c.json"}}, {"family": "Mantovani", "given": "Alberto", "initials": "A"}, {"family": "Mu\u00f1oz", "given": "Amalia", "initials": "A"}, {"family": "Omeragic", "given": "Elma", "initials": "E", "orcid": "0000-0002-5996-4926", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ab6ff466682485ebe5f7d0421b68e6e.json"}}, {"family": "Parissis", "given": "Nikolaos", "initials": "N", "orcid": "0000-0001-9478-0885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bff67e49a37d4969b4e88e8cc93344be.json"}}, {"family": "Petrillo", "given": "Mauro", "initials": "M", "orcid": "0000-0002-6782-4704", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8183c35e5c7b40d1a7ea56a85521451b.json"}}, {"family": "Saarim\u00e4ki", "given": "Laura A", "initials": "LA"}, {"family": "Soares", "given": "Helena", "initials": "H", "orcid": "0000-0002-5881-3843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f70a530898734960b5e71b665ecefedf.json"}}, {"family": "Sullivan", "given": "Kristie", "initials": "K"}, {"family": "Landesmann", "given": "Brigitte", "initials": "B"}], "type": "journal article", "published": "2022-07-31", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "11", "issue": "15", "issn-l": "2077-0383"}, "abstract": "Addressing factors modulating COVID-19 is crucial since abundant clinical evidence shows that outcomes are markedly heterogeneous between patients. This requires identifying the factors and understanding how they mechanistically influence COVID-19. Here, we describe how eleven selected factors (age, sex, genetic factors, lipid disorders, heart failure, gut dysbiosis, diet, vitamin D deficiency, air pollution and exposure to chemicals) influence COVID-19 by applying the Adverse Outcome Pathway (AOP), which is well-established in regulatory toxicology. This framework aims to model the sequence of events leading to an adverse health outcome. Several linear AOPs depicting pathways from the binding of the virus to ACE2 up to clinical outcomes observed in COVID-19 have been developed and integrated into a network offering a unique overview of the mechanisms underlying the disease. As SARS-CoV-2 infectibility and ACE2 activity are the major starting points and inflammatory response is central in the development of COVID-19, we evaluated how those eleven intrinsic and extrinsic factors modulate those processes impacting clinical outcomes. Applying this AOP-aligned approach enables the identification of current knowledge gaps orientating for further research and allows to propose biomarkers to identify of high-risk patients. This approach also facilitates expertise synergy from different disciplines to address public health issues.", "doi": "10.3390/jcm11154464", "pmid": "35956081", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jcm11154464"}, {"db": "pmc", "key": "PMC9369763"}], "notes": [], "created": "2022-08-16T15:41:27.289Z", "modified": "2022-08-16T15:41:48.989Z"}, {"entity": "publication", "iuid": "db6c2aa233d643e591911f4079de01cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db6c2aa233d643e591911f4079de01cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db6c2aa233d643e591911f4079de01cb"}}, "title": "VACCELERATE Volunteer Registry: A European study participant database to facilitate clinical trial enrolment.", "authors": [{"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J"}, {"family": "Stewart", "given": "Fiona A", "initials": "FA"}, {"family": "Heringer", "given": "Sarah", "initials": "S"}, {"family": "Koniordou", "given": "Markela", "initials": "M"}, {"family": "\u00c1lvarez-Barco", "given": "Elena", "initials": "E"}, {"family": "Argyropoulos", "given": "Christos D", "initials": "CD"}, {"family": "Themistocleous", "given": "Sophia C", "initials": "SC"}, {"family": "Valle-Sim\u00f3n", "given": "Paula", "initials": "P"}, {"family": "Spivak", "given": "Orly", "initials": "O"}, {"family": "Sou\u010dkov\u00e1", "given": "Lenka", "initials": "L"}, {"family": "Merakou", "given": "Christina", "initials": "C"}, {"family": "Am\u00e9lia Mendon\u00e7a", "given": "Maria", "initials": "M"}, {"family": "Joanna Davis", "given": "Ruth", "initials": "R"}, {"family": "Maria Azzini", "given": "Anna", "initials": "A"}, {"family": "Askling", "given": "Helena H", "initials": "HH"}, {"family": "Vene", "given": "Sirkka", "initials": "S"}, {"family": "Van Damme", "given": "Pierre", "initials": "P"}, {"family": "Steinbach", "given": "Angela", "initials": "A"}, {"family": "Shiamakkides", "given": "George", "initials": "G"}, {"family": "Seidel", "given": "Danila", "initials": "D"}, {"family": "Olesen", "given": "Ole F", "initials": "OF"}, {"family": "Noula", "given": "Evgenia", "initials": "E"}, {"family": "Macken", "given": "Alan", "initials": "A"}, {"family": "Lu\u00eds", "given": "Catarina", "initials": "C"}, {"family": "Leckler", "given": "Janina", "initials": "J"}, {"family": "Launay", "given": "Odile", "initials": "O"}, {"family": "Isitt", "given": "Catherine", "initials": "C"}, {"family": "Hellemans", "given": "Margot", "initials": "M"}, {"family": "Fr\u00edas-Iniesta", "given": "Jes\u00fas", "initials": "J"}, {"family": "Di Marzo", "given": "Romina", "initials": "R"}, {"family": "Carcas", "given": "Antonio J", "initials": "AJ"}, {"family": "Boustras", "given": "George", "initials": "G"}, {"family": "Borobia", "given": "Alberto M", "initials": "AM"}, {"family": "Barta", "given": "Imre", "initials": "I"}, {"family": "Albus", "given": "Kerstin", "initials": "K"}, {"family": "Akova", "given": "Murat", "initials": "M"}, {"family": "Ochando", "given": "Jordi", "initials": "J"}, {"family": "Cohen-Kandli", "given": "Miriam", "initials": "M"}, {"family": "Jane Cox", "given": "Rebecca", "initials": "R"}, {"family": "Husa", "given": "Petr", "initials": "P"}, {"family": "Jancoriene", "given": "Ligita", "initials": "L"}, {"family": "Mallon", "given": "Patrick", "initials": "P"}, {"family": "Marques", "given": "Laura", "initials": "L"}, {"family": "Mellinghoff", "given": "Sibylle C", "initials": "SC"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}, {"family": "Tacconelli", "given": "Evelina", "initials": "E"}, {"family": "T\u00f3th", "given": "Krisztina", "initials": "K"}, {"family": "Zaoutis", "given": "Theoklis E", "initials": "TE"}, {"family": "Zeitlinger", "given": "Markus", "initials": "M"}, {"family": "Cornely", "given": "Oliver A", "initials": "OA"}, {"family": "Pana", "given": "Zoi-Dorothea", "initials": "ZD"}, {"family": "VACCELERATE consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-29", "journal": {"title": "Vaccine", "issn": "1873-2518", "volume": "40", "issue": "31", "pages": "4090-4097", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has evidenced the key role of vaccine design, obtention, production and administration to successfully fight against infectious diseases and to provide efficient remedies for the citizens. Although clinical trials were rapidly established during this pandemic, identifying suitable study subjects can be challenging. For this reason, the University Hospital Cologne established a volunteer registry for participation in clinical trials first in Germany, which has now been incorporated into the European VACCELERATE clinical trials network and grew to a European Volunteer Registry. As such, VACCELERATE's Volunteer Registry aims to become a common entry point for potential volunteers in future clinical trials in Europe.\n\nInterested volunteers who would like to register for clinical trials in the VACCELERATE Volunteer Registry can access the registration questionnaire via http://www.vaccelerate.eu/volunteer-registry. Potential volunteers are requested to provide their current country and area of residence, contact information, including first and last name and e-mail address, age, gender, comorbidities, previous SARS-CoV-2 infection and vaccination status, and maximum distance willing to travel to a clinical trial site. The registry is open to both adults and children, complying with national legal consent requirements.\n\nAs of May 2022, the questionnaire is available in 12 countries and 14 languages. Up to date, more than 36,000 volunteers have registered, mainly from Germany. Within the first year since its establishment, the VACCELERATE Volunteer Registry has matched more than 15,000 volunteers to clinical trials. The VACCELERATE Volunteer Registry will be launched in further European countries in the coming months.\n\nThe VACCELERATE Volunteer Registry is an active single-entry point for European residents interested in COVID-19 clinical trials participation in 12 countries (i.e., Austria, Cyprus, Germany, Greece, Ireland, Lithuania, Norway, Portugal, Spain, Sweden and Turkey). To date, more than 15,000 registered individuals have been connected to clinical trials in Germany alone. The registry is currently in the implementation phase in 5 additional countries (i.e., Belgium, Czech Republic, Hungary, Israel and the Netherlands).", "doi": "10.1016/j.vaccine.2022.05.022", "pmid": "35659449", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(22)00605-3"}], "notes": [], "created": "2022-06-21T17:17:31.581Z", "modified": "2022-06-21T17:17:31.596Z"}, {"entity": "publication", "iuid": "bdf06c9002824a688b8b0092806ac1e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bdf06c9002824a688b8b0092806ac1e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bdf06c9002824a688b8b0092806ac1e1"}}, "title": "Serum concentration of extracellular cold-inducible RNA-binding protein is associated with respiratory failure in COVID-19.", "authors": [{"family": "Schagatay", "given": "Felix", "initials": "F"}, {"family": "Diamant", "given": "Klara", "initials": "K"}, {"family": "Lid\u00e9n", "given": "Mats", "initials": "M"}, {"family": "Edin", "given": "Alicia", "initials": "A"}, {"family": "Athlin", "given": "Simon", "initials": "S"}, {"family": "Hultgren", "given": "Olof", "initials": "O"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Savilampi", "given": "Johanna", "initials": "J"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Lange", "given": "Anna", "initials": "A"}, {"family": "Cajander", "given": "Sara", "initials": "S"}], "type": "journal article", "published": "2022-07-29", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "13", "pages": "945603", "issn-l": "1664-3224"}, "abstract": "Uncontrolled release of damage-associated molecular patterns (DAMPs) is suggested to be a major trigger for the dysregulated host immune response that leads to severe COVID-19. Cold-inducible RNA-binding protein (CIRP), is a newly identified DAMP that aggravates inflammation and tissue injury, and induces respiratory failure in sepsis. Whether CIRP contributes to the pathogenesis of respiratory failure in COVID-19 has not yet been explored.\n\nTo investigate if the concentration of extracellular CIRP (eCIRP) in serum associates with respiratory failure and lung involvement by chest computed tomography (CT) in COVID-19.\n\nHerein we report a prospective observational study of patients with COVID-19 included at two University Hospitals in Sweden between April 2020 and May 2021. Serum from hospitalized patients in \u00d6rebro (N=97) were used to assess the association between eCIRP and the level of respiratory support and its correlation with pulmonary involvement on chest CT and inflammatory biomarkers. A cohort of hospitalized and non-hospitalized patients from Ume\u00e5 (N=78) was used as an external validation cohort. The severity of disease was defined according to the highest degree of respiratory support; mild disease (no oxygen), non-severe hypoxemia (conventional oxygen or high-flow nasal oxygen, HFNO <50% FiO2), and severe hypoxemia (HFNO \u226550% FiO2, mechanical ventilation). Unadjusted and adjusted linear regression was used to evaluate peak eCIRP day 0-4 in respect to severity, age, sex, Charlson comorbidity score, symptom duration, and BMI.\n\nPeak eCIRP concentrations were higher in patients with severe hypoxemia and were independently associated with the degree of respiratory support in both cohorts (\u00d6rebro; p=0.01, Ume\u00e5; p<0.01). The degree of pulmonary involvement measured by CT correlated with eCIRP, rs=0.30, p<0.01 (n=97).\n\nHigh serum levels of eCIRP are associated with acute respiratory failure in COVID-19. Experimental studies are needed to determine if treatments targeting eCIRP reduces the risk of acute respiratory failure in COVID-19.", "doi": "10.3389/fimmu.2022.945603", "pmid": "35967397", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9373926"}], "notes": [], "created": "2022-08-16T15:37:26.634Z", "modified": "2022-08-19T05:27:23.777Z"}, {"entity": "publication", "iuid": "0d58d4714dae496c88ba1233e54f236e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d58d4714dae496c88ba1233e54f236e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d58d4714dae496c88ba1233e54f236e"}}, "title": "Healthy workplace onboard: Insights gained from the COVID-19 impact on mental health and wellbeing of seafarers.", "authors": [{"family": "Carrera-Arce", "given": "Maria", "initials": "M"}, {"family": "Bartusevi\u010dien\u0117", "given": "Inga", "initials": "I"}, {"family": "Divari", "given": "Paschalia", "initials": "P"}], "type": "journal article", "published": "2022-07-29", "journal": {"title": "Work", "issn": "1875-9270", "issn-l": null}, "abstract": "Seafarers' psychological health is seriously affected by COVID-19. The pandemic could act as a catalyst for change with respect to seafarers' mental health protection and promotion.\n\nThe study explores the main factors contributing to the mental health and wellbeing of seafarers. Moreover, elements to help seafarers lessen the impact of the pandemic on their work and life onboard are analyzed, and their role in developing a positive psychosocial environment and promoting a healthy workplace onboard are discussed.\n\nThe study involved the use of an ad hoc questionnaire and the adoption of both quantitative and qualitative methods. The sample included one hundred and five active seafarers.\n\nNinety-six percent of the sample stated that mental health is a very or extremely important part of their general health. Seafarers perceive that their mental health has been seriously impacted by COVID-19. Major factors contributing to seafarers' mental health and wellbeing reveal three groups of factors: rest and spare time-related factors, communication/relationship with the external world, and interaction and social life on board factors.\n\nStrategies suggested by seafarers for coping with \"inevitable\" psychological stress produced by COVID-19 and promoting their wellbeing include managerial, emotional, facilities-related (including communication infrastructure), physical, and social elements to promote wellbeing. Economic, intellectual, and spiritual elements also have to be taken into consideration and require further investigation. Building on seafarers' insights and experiences, a healthy environment onboard should cultivate holistically the four main spheres of a healthy workplace (physical work environment, psychosocial work environment, personal health resources, and enterprise community involvement) and the five features of a healthy psychosocial environment (social, emotional, physical, intellectual and spiritual) under all circumstances, whether exceptional or ordinary.", "doi": "10.3233/WOR-210791", "pmid": "35912771", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "WOR210791"}], "notes": [], "created": "2022-08-11T12:04:07.487Z", "modified": "2022-08-11T12:04:07.502Z"}, {"entity": "publication", "iuid": "853c5874292242dea1b45360476495d6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/853c5874292242dea1b45360476495d6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/853c5874292242dea1b45360476495d6"}}, "title": "Protein Expression Profile of ACE2 in the Normal and COVID-19-Affected Human Brain.", "authors": [{"family": "Lindskog", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-5611-1015", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4ead3d38a364b66ac069b9c8bf63897.json"}}, {"family": "M\u00e9ar", "given": "Loren", "initials": "L", "orcid": "0000-0001-9333-0110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/344121b8f2524853a820ad52ea8de328.json"}}, {"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "F\u00e4llmar", "given": "David", "initials": "D"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Hesselager", "given": "G\u00f6ran", "initials": "G"}, {"family": "Casar-Borota", "given": "Olivera", "initials": "O"}, {"family": "Rostami", "given": "Elham", "initials": "E"}], "type": "journal article", "published": "2022-07-28", "journal": {"title": "J Proteome Res", "issn": "1535-3907", "issn-l": null}, "abstract": "SARS-coronavirus 2 (SARS-CoV-2) that caused the coronavirus disease 2019 (COVID-19) pandemic has posed to be a global challenge. An increasing number of neurological symptoms have been linked to the COVID-19 disease, but the underlying mechanisms of such symptoms and which patients could be at risk are not yet established. The suggested key receptor for host cell entry is angiotensin I converting enzyme 2 (ACE2). Previous studies on limited tissue material have shown no or low protein expression of ACE2 in the normal brain. Here, we used stringently validated antibodies and immunohistochemistry to examine the protein expression of ACE2 in all major regions of the normal brain. The expression pattern was compared with the COVID-19-affected brain of patients with a varying degree of neurological symptoms. In the normal brain, the expression was restricted to the choroid plexus and ependymal cells with no expression in any other brain cell types. Interestingly, in the COVID-19-affected brain, an upregulation of ACE2 was observed in endothelial cells of certain patients, most prominently in the white matter and with the highest expression observed in the patient with the most severe neurological symptoms. The data shows differential expression of ACE2 in the diseased brain and highlights the need to further study the role of endothelial cells in COVID-19 disease in relation to neurological symptoms.", "doi": "10.1021/acs.jproteome.2c00184", "pmid": "35901083", "labels": {"Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9364976"}], "notes": [], "created": "2022-08-12T08:32:57.108Z", "modified": "2022-08-12T08:32:57.176Z"}, {"entity": "publication", "iuid": "fd6adaa59c1f4e41bc3b8161bc015a7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fd6adaa59c1f4e41bc3b8161bc015a7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fd6adaa59c1f4e41bc3b8161bc015a7e"}}, "title": "From novel discovery tools and biomarkers to precision medicine - basic cardiovascular science highlights of 2021/2022.", "authors": [{"family": "Evans", "given": "Paul C", "initials": "PC", "orcid": "0000-0001-7975-681X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9bbd82269e844d92bdb953d9544fbc84.json"}}, {"family": "Davidson", "given": "Sean M", "initials": "SM"}, {"family": "Wojta", "given": "Johann", "initials": "J", "orcid": "0000-0002-1282-9276", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceed4186b4864c1e83d4dbaa35465b2c.json"}}, {"family": "B\u00e4ck", "given": "Magnus", "initials": "M"}, {"family": "Bollini", "given": "Sveva", "initials": "S"}, {"family": "Brittan", "given": "Mairi", "initials": "M", "orcid": "0000-0002-3830-200X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41994a2430ff4dfc82a5e2b95da0cef2.json"}}, {"family": "Catapano", "given": "Alberico L", "initials": "AL", "orcid": "0000-0002-7593-2094", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9be6543658dc4243b3692badcfb51112.json"}}, {"family": "Chaudhry", "given": "Bill", "initials": "B"}, {"family": "Cluitmans", "given": "Matthijs", "initials": "M"}, {"family": "Gnecchi", "given": "Massimiliano", "initials": "M", "orcid": "0000-0001-7435-4328", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b080766181f34bc6aaa22bf38a356839.json"}}, {"family": "Guzik", "given": "Tomasz J", "initials": "TJ", "orcid": "0000-0003-2012-1187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bba211a5749d45668559282301691367.json"}}, {"family": "Hoefer", "given": "Imo", "initials": "I"}, {"family": "Madonna", "given": "Rosalinda", "initials": "R", "orcid": "0000-0001-6455-2777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/628e83f26bb44f578c343e8801a9c848.json"}}, {"family": "Monteiro", "given": "Jo\u00e3o P", "initials": "JP"}, {"family": "Morawietz", "given": "Henning", "initials": "H"}, {"family": "Osto", "given": "Elena", "initials": "E", "orcid": "0000-0001-8196-5696", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8748792f9b8b412abbe0bdb9f5339adb.json"}}, {"family": "Padr\u00f3", "given": "Teresa", "initials": "T"}, {"family": "Sluimer", "given": "Judith C", "initials": "JC"}, {"family": "Tocchetti", "given": "Carlo Gabriele", "initials": "CG"}, {"family": "Van der Heiden", "given": "Kim", "initials": "K", "orcid": "0000-0002-6537-5992", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3450039095254822b1b3fae6a9b70720.json"}}, {"family": "Vilahur", "given": "Gemma", "initials": "G"}, {"family": "Waltenberger", "given": "Johannes", "initials": "J", "orcid": "0000-0002-2417-9880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92915958f5aa420d9562819756473451.json"}}, {"family": "Weber", "given": "Christian", "initials": "C", "orcid": "0000-0003-4610-8714", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c44b7ca02c624d62be15c61fcf389d54.json"}}], "type": "journal article", "published": "2022-07-28", "journal": {"title": "Cardiovasc Res", "issn": "1755-3245", "issn-l": null}, "abstract": "Here we review the highlights of cardiovascular basic science in published in 2021 and early 2022 on behalf of the European Society of Cardiology Council for Basic Cardiovascular Science. We begin with non-coding RNAs which have emerged as central regulators cardiovascular biology, and then discuss how technological developments in single-cell 'omics are providing new insights in cardiovascular development, inflammation and disease. We also review recent discoveries on the biology of extracellular vesicles in driving either protective or pathogenic responses. The Nobel Prize in Physiology or Medicine 2021 recognised the importance of the molecular basis of mechanosensing and here we review breakthroughs in cardiovascular sensing of mechanical force. We also summarise discoveries in the field of atherosclerosis including the role of clonal haematopoiesis of indeterminate potential, and new mechanisms of cross-talk between hyperglycemia, lipid mediators and inflammation. The past 12 months also witnessed major advances in the field of cardiac arrhythmia including new mechanisms of fibrillation. We also focus on inducible pluripotent stem cell (iPSC) technology which has demonstrated disease causality for several genetic polymorphisms in long QT syndrome and aortic valve disease, paving the way for personalized medicine approaches. Finally, the cardiovascular community has continued to better understand COVID-19 with significant advancement in our knowledge of cardiovascular tropism, molecular markers, the mechanism of vaccine-induced thrombotic complications and new anti-viral therapies that protect the cardiovascular system.", "doi": "10.1093/cvr/cvac114", "pmid": "35899362", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6650923"}], "notes": [], "created": "2022-08-12T08:33:39.207Z", "modified": "2022-08-12T08:33:39.606Z"}, {"entity": "publication", "iuid": "ac4dffd654da4755949ea87002895b09", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac4dffd654da4755949ea87002895b09.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac4dffd654da4755949ea87002895b09"}}, "title": "Sociodemographic and Occupational Factors Associated with Low Early Uptake of COVID-19 Vaccine in Hospital-Based Healthcare Workers, Georgia, March-July 2021.", "authors": [{"family": "Lucaccioni", "given": "H\u00e9lo\u00efse", "initials": "H", "orcid": "0000-0003-3080-9794", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5850aabf8a674ee2971fe111b880aeba.json"}}, {"family": "Chakhunashvili", "given": "Giorgi", "initials": "G"}, {"family": "McKnight", "given": "Carl Jason", "initials": "CJ"}, {"family": "Zardiashvili", "given": "Tamila", "initials": "T"}, {"family": "Jorgensen", "given": "Pernille", "initials": "P"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "Kissling", "given": "Esther", "initials": "E"}, {"family": "Katz", "given": "Mark A", "initials": "MA", "orcid": "0000-0002-5532-7276", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/890f00845e274820b1b78a0829f4d01f.json"}}, {"family": "Sanodze", "given": "Lia", "initials": "L"}], "type": "journal article", "published": "2022-07-27", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "In Georgia, an upper-middle income European country, the COVID-19 vaccine rollout began on 15 March 2021 with health workers (HWs), a priority group for vaccination. We assessed the factors associated with COVID-19 vaccination among HWs at six large hospitals in the early stages of the vaccine rollout (March-July 2021). Among 1533 HWs, 274 (17.9%) had received one dose of the COVID-19 vaccine. Strong independent predictors of early vaccine uptake were age &gt; 40 years, especially 50-59 years old (aOR 2.40, 95% CI 1.50-3.88), considering the vaccine as \"somewhat effective\" or \"very effective\" rather than \"not effective\" (aOR 6.33, 95% CI 2.29-26.3 and aOR 10.9, 95% CI 3.88-45.70, respectively), and previous vaccination against seasonal influenza (aOR 2.98, 95% CI 2.19-4.08). Previous SARS-CoV-2 infection was negatively associated with receiving the vaccine (aOR 0.6, 95% CI 0.40-0.80). Compared to physicians, nurses/midwives (aOR 0.22, 95% CI 0.15-0.32), administrative staff (aOR 0.36, 95% CI 0.22-0.56), and ancillary staff (aOR 0.07, 95% CI 0.04-0.15) were less likely to have received the COVID-19 vaccine. Tailoring the COVID-19 vaccine communications campaign to younger and non-physician HWs, and emphasizing the benefits of the COVID-19 vaccine, could help further increase vaccine coverage among HWs in Georgia.", "doi": "10.3390/vaccines10081197", "pmid": "36016084", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "vaccines10081197"}, {"db": "pmc", "key": "PMC9415840"}], "notes": [], "created": "2022-09-12T19:09:52.564Z", "modified": "2022-09-12T19:10:59.840Z"}, {"entity": "publication", "iuid": "838d5e0781814dc0b5b565581bd02829", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/838d5e0781814dc0b5b565581bd02829.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/838d5e0781814dc0b5b565581bd02829"}}, "title": "Silence Among First-Line Managers in Eldercare and Their Continuous Improvement Work During Covid-19.", "authors": [{"family": "Dellve", "given": "Lotta", "initials": "L", "orcid": "0000-0003-0480-1895", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/796e0052b7eb49629ac24f9fc455ce5a.json"}}, {"family": "Jendeby", "given": "Mimmi Kheddache", "initials": "MK", "orcid": "0000-0002-9756-0607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef79afa452a845f18b07a3963567e045.json"}}], "type": "journal article", "published": "2022-07-27", "journal": {"title": "Inquiry", "issn": "1945-7243", "volume": "59", "pages": "469580221107052", "issn-l": null}, "abstract": "Eldercare sector faced severe needs, and unexplained difficulties, to manage daily work and the continuous improvement of routines at operative levels during Covid-19. First-line managers in eldercare have a key role to facilitate learnings but may be hindered in public, hierarchical organizations. This is the first study on the conditions and importance of silence for managerial work in terms of daily operations and continuous improvement work. To identify first-line managers' silence in eldercare, its contextual and supportive conditions, its reasons and its implications for managerial work with regard to daily operations and continuous improvement work. Mixed-method study based on a questionnaire to first-line managers (n = 189) in Swedish public eldercare in 33 randomly selected municipal organizations and one city. The instruments Communication of Critical Issues at Work, Managers Stress Inventory and Managerial Work and an open question were analyzed using: (1) qualitative coding to explore organizational conditions, (2) descriptive statistics, and (3) stepwise regressions to identify associations. The most common forms of silence were quiescent (based on fear of the consequences of speaking up) and acquiescent (based on resignation and demotivation). Organizational conditions shaping managerial silence were due to strict governance and control in a hierarchical organization, lack of support and participation in decision-making and the experience of not being valued. Managers' silence had a negative impact on managerial work and especially work on continuous improvements. The pandemic also offered space for values of occupational professionalism and learning at operational levels. Organizational conditions of support through superiors and management teams decreased silence. Manager silence is detrimental for continuous improvement work and may arise in organizations with dominant values of organizational professionalism. Supportive conditions based on trust and space for occupational professionalism may be important and should be improved to decrease managerial silence and better support continuous improvements.", "doi": "10.1177/00469580221107052", "pmid": "35880855", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9340405"}], "notes": [], "created": "2022-08-12T08:38:02.656Z", "modified": "2022-08-12T08:38:02.745Z"}, {"entity": "publication", "iuid": "38d6d243fdea4bc899b9df57c001eb57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38d6d243fdea4bc899b9df57c001eb57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38d6d243fdea4bc899b9df57c001eb57"}}, "title": "NMR Experiments Provide Insights into Ligand-Binding to the SARS-CoV-2 Spike Protein Receptor-Binding Domain.", "authors": [{"family": "Creutznacher", "given": "Robert", "initials": "R"}, {"family": "Maass", "given": "Thorben", "initials": "T"}, {"family": "Veselkova", "given": "Barbora", "initials": "B"}, {"family": "Ssebyatika", "given": "George", "initials": "G"}, {"family": "Krey", "given": "Thomas", "initials": "T"}, {"family": "Empting", "given": "Martin", "initials": "M"}, {"family": "Tautz", "given": "Norbert", "initials": "N"}, {"family": "Frank", "given": "Martin", "initials": "M"}, {"family": "K\u00f6lbel", "given": "Knut", "initials": "K"}, {"family": "Uetrecht", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1991-7922", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb624da1299f4c7fb23cbb6ed98d5338.json"}}, {"family": "Peters", "given": "Thomas", "initials": "T", "orcid": "0000-0002-7570-8260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f8c890c3f7e4b1688e247f1920fafa8.json"}}], "type": "journal article", "published": "2022-07-27", "journal": {"title": "J Am Chem Soc", "issn": "1520-5126", "volume": "144", "issue": "29", "pages": "13060-13065", "issn-l": null}, "abstract": "We have used chemical shift perturbation (CSP) and saturation transfer difference (STD) NMR experiments to identify and characterize the binding of selected ligands to the receptor-binding domain (RBD) of the spike glycoprotein (S-protein) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We also subjected full-length S-protein to STD NMR experiments, allowing correlations with RBD-based results. CSPs reveal the binding sites for heparin and fondaparinux, and affinities were measured using CSP titrations. We then show that \u03b1-2,3-sialyllactose binds to the S-protein but not to the RBD. Finally, combined CSP and STD NMR experiments show that lifitegrast, a compound used for the treatment of dry eye, binds to the linoleic acid (LA) binding pocket with a dissociation constant in the \u03bcM range. This is an interesting finding, as lifitegrast lends itself well as a blueprint for medicinal chemistry, eventually furnishing novel entry inhibitors targeting the highly conserved LA binding site.", "doi": "10.1021/jacs.2c05603", "pmid": "35830336", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-17T10:35:23.171Z", "modified": "2022-08-17T10:36:02.991Z"}, {"entity": "publication", "iuid": "65043fd61ce841a99504d2db8c4cb5e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65043fd61ce841a99504d2db8c4cb5e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65043fd61ce841a99504d2db8c4cb5e8"}}, "title": "Macrotroponin Complex as a Cause for Cardiac Troponin Increase after COVID-19 Vaccination and Infection.", "authors": [{"family": "Bularga", "given": "Anda", "initials": "A", "orcid": "0000-0002-5530-527X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91b19a9407f94a29aaa1c010933a5971.json"}}, {"family": "Oskoui", "given": "Ellen", "initials": "E"}, {"family": "Fujisawa", "given": "Takeshi", "initials": "T"}, {"family": "Jenks", "given": "Sara", "initials": "S"}, {"family": "Sutherland", "given": "Rachel", "initials": "R"}, {"family": "Apple", "given": "Fred S", "initials": "FS"}, {"family": "Hammarsten", "given": "Ola", "initials": "O"}, {"family": "Mills", "given": "Nicholas L", "initials": "NL", "orcid": "0000-0003-0533-7991", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c76e317e697744878fd74d19e720df4c.json"}}], "type": "journal article", "published": "2022-07-27", "journal": {"title": "Clin Chem", "issn": "1530-8561", "volume": "68", "issue": "8", "pages": "1015-1019", "issn-l": "0009-9147"}, "abstract": null, "doi": "10.1093/clinchem/hvac100", "pmid": "35896175", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6650785"}], "notes": [], "created": "2022-08-12T08:34:39.276Z", "modified": "2022-08-12T08:34:39.362Z"}, {"entity": "publication", "iuid": "fab6ff995328484bb42b4f6f4ee2375f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fab6ff995328484bb42b4f6f4ee2375f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fab6ff995328484bb42b4f6f4ee2375f"}}, "title": "Hypertension in COVID-19, A Risk Factor for Infection or A Late Consequence?", "authors": [{"family": "Barekat", "given": "Maryam", "initials": "M"}, {"family": "Shahrbaf", "given": "Mohammad Amin", "initials": "MA"}, {"family": "Rahi", "given": "Kosar", "initials": "K"}, {"family": "Vosough", "given": "Massoud", "initials": "M"}], "type": "journal article", "published": "2022-07-27", "journal": {"title": "Cell J", "issn": "2228-5806", "volume": "24", "issue": "7", "pages": "424-426", "issn-l": null}, "abstract": "There are a lot of data about the correlation of SARS-CoV-2 infection and hypertension (HTN), but most of them are in the increased risk of morbidity and mortality in patients with HTN. SARS-CoV-2 can interfere with host cells through the renin-angiotensin system (RAS) via the angiotensin-converting enzyme 2 (ACE2) receptor. RAS activation is associated with pro-inflammatory effects through the ACE/Ang II/ Angiotensin II type 1 receptor (AT1R) pathway or anti-inflammatory effects through ACE2/Ang1-7/Mas axis. In the current paper, we discuss the pathophysiology of newly diagnosed HTN and its effect on morbidity in patients with coronavirus disease 2019 (COVID-19).", "doi": "10.22074/cellj.2022.8487", "pmid": "36043411", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9428472"}], "notes": [], "created": "2022-10-13T13:05:46.781Z", "modified": "2022-10-13T13:05:46.809Z"}, {"entity": "publication", "iuid": "e78151a5b69344e8ab24d133a2f328e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e78151a5b69344e8ab24d133a2f328e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e78151a5b69344e8ab24d133a2f328e8"}}, "title": "Transient and durable T cell reactivity after COVID-19.", "authors": [{"family": "Martner", "given": "Anna", "initials": "A", "orcid": "0000-0002-6598-5221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c11a2e719c534772a129782bfb60d35c.json"}}, {"family": "Grauers Wiktorin", "given": "Hanna", "initials": "H", "orcid": "0000-0002-4412-5695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a08f604e1f94feda4e60f01d728e68f.json"}}, {"family": "T\u00f6rnell", "given": "Andreas", "initials": "A", "orcid": "0000-0003-0769-2815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0e49354b88f4f7c8792dfb4216561c8.json"}}, {"family": "Ringlander", "given": "Johan", "initials": "J", "orcid": "0000-0002-8483-6504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64f85af7dceb436498422e62f1a98c89.json"}}, {"family": "Arabpour", "given": "Mohammad", "initials": "M"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-6617-5976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7bda9f192dc44c587d8a252ef16516b.json"}}], "type": "journal article", "published": "2022-07-26", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "119", "issue": "30", "pages": "e2203659119", "issn-l": "0027-8424"}, "abstract": "This study analyzed whole blood samples (n = 56) retrieved from 30 patients at 1 to 21 (median 9) mo after verified COVID-19 to determine the polarity and duration of antigen-specific T cell reactivity against severe acute respiratory syndrome coronavirus 2-derived antigens. Multimeric peptides spanning the entire nucleocapsid protein triggered strikingly synchronous formation of interleukin (IL)-4, IL-12, IL-13, and IL-17 ex vivo until \u223c70 d after confirmed infection, whereafter this reactivity was no longer inducible. In contrast, levels of nucleocapsid-induced IL-2 and interferon-\u03b3 remained stable and highly correlated at 3 to 21 mo after infection. Similar cytokine dynamics were observed in unvaccinated, convalescent patients using whole-blood samples stimulated with peptides spanning the N-terminal portion of the spike 1 protein. These results unravel two phases of T cell reactivity following natural COVID-19: an early, synchronous response indicating transient presence of multipolar, antigen-specific T helper (TH) cells followed by an equally synchronous and durable TH1-like reactivity reflecting long-lasting T cell memory.", "doi": "10.1073/pnas.2203659119", "pmid": "35858456", "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9335198"}], "notes": [], "created": "2022-08-12T08:44:58.936Z", "modified": "2022-08-12T08:45:19.541Z"}, {"entity": "publication", "iuid": "9fab4c18e8884e05879f96f6e51a805a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9fab4c18e8884e05879f96f6e51a805a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9fab4c18e8884e05879f96f6e51a805a"}}, "title": "Examining the relationship between alcohol consumption, psychological distress and COVID-19 related circumstances: An Australian longitudinal study in the first year of the pandemic.", "authors": [{"family": "Mojica-Perez", "given": "Yvette", "initials": "Y"}, {"family": "Livingston", "given": "Michael", "initials": "M"}, {"family": "Pennay", "given": "Amy", "initials": "A"}, {"family": "Callinan", "given": "Sarah", "initials": "S"}], "type": "journal article", "published": "2022-07-26", "journal": {"title": "Addict Behav", "issn": "1873-6327", "volume": "135", "pages": "107439", "issn-l": null}, "abstract": "The aim of this study is to examine the relationship between alcohol consumption, psychological distress and COVID-19 related circumstances (being in lockdown, working from home, providing home-schooling and being furloughed) over the first eight months of the pandemic in Australia.\n\nA longitudinal study with six survey waves over eight months with a convenience sample of 770 participants. Participants were aged 18 or over, lived in Australia and consumed alcohol at least monthly. Demographic data was obtained in the first wave. Data on alcohol consumption, psychological distress (Kessler 10), and COVID-19 related circumstances (being in lockdown, working from home, providing home-schooling and being furloughed) were obtained in each survey wave.\n\nResults from the fixed-effect bivariate regression analyses show that participants reported greater alcohol consumption when they had high psychological distress compared to when they had low psychological distress. Meanwhile, participants reported greater alcohol consumption when they worked from home compared to when they did not work from home. Participants also reported greater alcohol consumption when they provided home-schooling compared with when they did not provide home-schooling. The fixed-effect panel multivariable regression analyses indicated a longitudinal relationship between higher psychological distress and providing home-schooling on increased alcohol consumption.\n\nBroader drinking trends during the COVID-19 pandemic typically indicate increases and decreases in drinking among different members of the population. This study demonstrates that in Australia, it was those who experienced psychological distress and specific impacts of COVID-19 restrictions that were more likely to increase their drinking.", "doi": "10.1016/j.addbeh.2022.107439", "pmid": "35914417", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0306-4603(22)00205-2"}, {"db": "pmc", "key": "PMC9316938"}], "notes": [], "created": "2022-08-11T12:03:50.721Z", "modified": "2022-08-11T12:03:50.763Z"}, {"entity": "publication", "iuid": "081d960b8d3d42cfa84e0fbd8d246cd8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/081d960b8d3d42cfa84e0fbd8d246cd8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/081d960b8d3d42cfa84e0fbd8d246cd8"}}, "title": "Assessing the effectiveness of public health interventions for Covid-19 in Greece and Cyprus.", "authors": [{"family": "Zahariadis", "given": "Nikolaos", "initials": "N"}, {"family": "Exadaktylos", "given": "Theofanis", "initials": "T"}, {"family": "Sparf", "given": "J\u00f6rgen", "initials": "J"}, {"family": "Petridou", "given": "Evangelia", "initials": "E"}, {"family": "Kyriakidis", "given": "Alexandros", "initials": "A"}, {"family": "Papadopoulos", "given": "Ioannis", "initials": "I"}], "type": "journal article", "published": "2022-07-26", "journal": {"title": "Eur Policy Anal", "issn": "2380-6567", "issn-l": null}, "abstract": "In this article, we statistically examine the effectiveness of non-pharmaceutical interventions (NPIs) implemented by the national governments of Greece and Cyprus during 2020 to (a) limit the spread of the SARS-CoV-2 virus, and (b) mitigate the economic fallout brought about by the Covid-19 pandemic. Applying a modified health belief model, we hypothesize that behavioral outcomes at the policy level are a function of NPIs, perceived severity, and social context. We employ a Prais-Winsten estimation in 2-week averages and report panel-corrected standard errors to find that NPIs have clear, yet differential, effects on public health and the economy in terms of statistical significance and time lags. The study provides a critical framework to inform future interventions during emerging pandemics.", "doi": "10.1002/epa2.1153", "pmid": "35942067", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "EPA21153"}, {"db": "pmc", "key": "PMC9349912"}], "notes": [], "created": "2022-08-11T11:49:57.708Z", "modified": "2022-08-11T11:50:13.852Z"}, {"entity": "publication", "iuid": "b1eda1cb4a3a4ebd9a243040fd49a220", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1eda1cb4a3a4ebd9a243040fd49a220.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1eda1cb4a3a4ebd9a243040fd49a220"}}, "title": "Adolescents' Experience of Stress: A Focus Group Interview Study with 16-19-Year-Old Students during the COVID-19 Pandemic.", "authors": [{"family": "Perming", "given": "Camilla", "initials": "C"}, {"family": "Thurn", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Garmy", "given": "Pernilla", "initials": "P", "orcid": "0000-0003-1643-0171", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc4733a9e87a42fea6e7a7323feb61b3.json"}}, {"family": "Einberg", "given": "Eva-Lena", "initials": "EL", "orcid": "0000-0002-5586-3810", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d67e636861d492fb682ec1601422cd0.json"}}], "type": "journal article", "published": "2022-07-26", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "15", "issn-l": null}, "abstract": "The purpose was to investigate stress among adolescents (16-19 years old) during the coronavirus disease 2019 (COVID-19) pandemic. Focus group (n = 9) interviews with students at upper secondary schools (16-19 years old, n = 41) were conducted in southern Sweden during the COVID-19 pandemic in 2021. The interviews were analyzed by qualitative content analysis. The analysis revealed five categories of experience of stress: (1) School-related stress, (2) Stress in relationships and leisure, (3) How stress manifests itself, (4) Stress can increase performance, and (5) Experiences of counteracting stress. The adolescents in the study experienced stress linked to school and relationships, partly due to the COVID-19 pandemic. Distance education during the COVID-19 pandemic increased stress levels. The adolescents stated that high stress levels were experienced negatively and impaired their ability to perform, while moderate stress could contribute to achieving goals and improving performance. School nurses and other health professionals who meet with adolescents are important to support adolescents experiencing stress.", "doi": "10.3390/ijerph19159114", "pmid": "35897483", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19159114"}, {"db": "pmc", "key": "PMC9331051"}], "notes": [], "created": "2022-08-12T08:34:09.420Z", "modified": "2022-08-12T08:34:09.460Z"}, {"entity": "publication", "iuid": "27e5c782afdf4fc3a0742d51b72f6c3a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27e5c782afdf4fc3a0742d51b72f6c3a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27e5c782afdf4fc3a0742d51b72f6c3a"}}, "title": "The Inhibitory Potential of Ferulic Acid Derivatives against the SARS-CoV-2 Main Protease: Molecular Docking, Molecular Dynamics, and ADMET Evaluation.", "authors": [{"family": "Antonopoulou", "given": "Io", "initials": "I", "orcid": "0000-0002-7754-9398", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b07903ae8ac9453ca0e9b1005ab2137e.json"}}, {"family": "Sapountzaki", "given": "Eleftheria", "initials": "E"}, {"family": "Rova", "given": "Ulrika", "initials": "U", "orcid": "0000-0001-7500-2367", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9d7082ee4c84d308472242f35055e9f.json"}}, {"family": "Christakopoulos", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2022-07-25", "journal": {"title": "Biomedicines", "issn": "2227-9059", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "The main protease (Mpro) of SARS-CoV-2 is an appealing target for the development of antiviral compounds, due to its critical role in the viral life cycle and its high conservation among different coronaviruses and the continuously emerging mutants of SARS-CoV-2. Ferulic acid (FA) is a phytochemical with several health benefits that is abundant in plant biomass and has been used as a basis for the enzymatic or chemical synthesis of derivatives with improved properties, including antiviral activity against a range of viruses. This study tested 54 reported FA derivatives for their inhibitory potential against Mpro by in silico simulations. Molecular docking was performed using Autodock Vina, resulting in comparable or better binding affinities for 14 compounds compared to the known inhibitors N3 and GC376. ADMET analysis showed limited bioavailability but significantly improved the solubility for the enzymatically synthesized hits while better bioavailability and druglikeness properties but higher toxicity were observed for the chemically synthesized ones. MD simulations confirmed the stability of the complexes of the most promising compounds with Mpro, highlighting FA rutinoside and compound e27 as the best candidates from each derivative category.", "doi": "10.3390/biomedicines10081787", "pmid": "35892687", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "biomedicines10081787"}, {"db": "pmc", "key": "PMC9329733"}], "notes": [], "created": "2022-08-12T08:34:56.494Z", "modified": "2022-08-12T08:34:56.598Z"}, {"entity": "publication", "iuid": "2803bd89db79418ebbde0e679249a6bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2803bd89db79418ebbde0e679249a6bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2803bd89db79418ebbde0e679249a6bf"}}, "title": "Inflammatory mediators profile in patients hospitalized with COVID-19: A comparative study.", "authors": [{"family": "Tufa", "given": "Abdisa", "initials": "A"}, {"family": "Gebremariam", "given": "Tewodros Haile", "initials": "TH"}, {"family": "Manyazewal", "given": "Tsegahun", "initials": "T"}, {"family": "Getinet", "given": "Tewodros", "initials": "T"}, {"family": "Webb", "given": "Dominic-Luc", "initials": "DL"}, {"family": "Hellstr\u00f6m", "given": "Per M", "initials": "PM"}, {"family": "Genet", "given": "Solomon", "initials": "S"}], "type": "journal article", "published": "2022-07-25", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "13", "pages": "964179", "issn-l": "1664-3224"}, "abstract": "Abnormal inflammatory mediator concentrations during SARS-CoV-2 infection may represent disease severity. We aimed to assess plasma inflammatory mediator concentrations in patients with SARS-CoV-2 in Addis Ababa, Ethiopia. In this study, 260 adults: 126 hospitalized patients with confirmed COVID-19 sorted into severity groups: severe (n=68) and mild or moderate (n=58), and 134 healthy controls were enrolled. We quantified 39 plasma inflammatory mediators using multiplex ELISA. Spearman rank correlation and Mann-Whitney U test were used to identify mechanistically coupled inflammatory mediators and compare disease severity. Compared to healthy controls, patients with COVID-19 had significantly higher levels of interleukins 1\u03b1, 2, 6, 7, 8, 10 and 15, C-reactive protein (CRP), serum amyloid A (SAA), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion protein 1 (VCAM-1), IFN-\u03b3-inducible protein-10 (IP-10, CXCL10), macrophage inflammatory protein-1 alpha (MIP-1\u03b1, CCL3), eotaxin-3 (CCL26), interferon-gamma (IFN-\u03b3), tumor necrosis factor-\u03b1 (TNF-\u03b1), basic fibroblast growth factor (bFGF), placental growth factor (PlGF), and fms-like tyrosine kinase 1 (Flt-1). Patients with severe COVID-19 had higher IL-10 and lower macrophage-derived chemokine (MDC, CCL22) compared to the mild or moderate group (P<0.05). In the receiver operating characteristic curve, SAA, IL-6 and CRP showed strong sensitivity and specificity in predicting the severity and prognosis of COVID-19. Greater age and higher CRP had a significant association with disease severity (P<0.05). Our findings reveal that CRP, SAA, VCAM-1, CXCL10, CCL22 and IL-10 levels are promising biomarkers for COVID-19 disease severity, suggesting that plasma inflammatory mediators could be used as warning indicators of COVID-19 severity, aid in COVID-19 prognosis and treatment.", "doi": "10.3389/fimmu.2022.964179", "pmid": "35958594", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC9359079"}], "notes": [], "created": "2022-08-16T15:40:42.715Z", "modified": "2022-08-16T15:40:48.502Z"}, {"entity": "publication", "iuid": "e423ccc6f6ef417e9c25f79beb912f33", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e423ccc6f6ef417e9c25f79beb912f33.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e423ccc6f6ef417e9c25f79beb912f33"}}, "title": "Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study.", "authors": [{"family": "Izadi", "given": "Zara", "initials": "Z"}, {"family": "Gianfrancesco", "given": "Milena A", "initials": "MA"}, {"family": "Schmajuk", "given": "Gabriela", "initials": "G"}, {"family": "Jacobsohn", "given": "Lindsay", "initials": "L"}, {"family": "Katz", "given": "Patricia", "initials": "P"}, {"family": "Rush", "given": "Stephanie", "initials": "S"}, {"family": "Ja", "given": "Clairissa", "initials": "C"}, {"family": "Taylor", "given": "Tiffany", "initials": "T"}, {"family": "Shidara", "given": "Kie", "initials": "K"}, {"family": "Danila", "given": "Maria I", "initials": "MI"}, {"family": "Wysham", "given": "Katherine D", "initials": "KD"}, {"family": "Strangfeld", "given": "Anja", "initials": "A"}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL"}, {"family": "Gossec", "given": "Laure", "initials": "L"}, {"family": "Carmona", "given": "Loreto", "initials": "L"}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S"}, {"family": "Kearsley-Fleet", "given": "Lianne", "initials": "L"}, {"family": "Schaefer", "given": "Martin", "initials": "M"}, {"family": "Al-Emadi", "given": "Samar", "initials": "S"}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA"}, {"family": "Hsu", "given": "Tiffany Y-T", "initials": "TY"}, {"family": "Patel", "given": "Naomi J", "initials": "NJ"}, {"family": "Wise", "given": "Leanna", "initials": "L"}, {"family": "Gilbert", "given": "Emily", "initials": "E"}, {"family": "Duarte-Garc\u00eda", "given": "Al\u00ed", "initials": "A"}, {"family": "Valenzuela-Almada", "given": "Maria O", "initials": "MO"}, {"family": "Ugarte-Gil", "given": "Manuel F", "initials": "MF"}, {"family": "Ljung", "given": "Lotta", "initials": "L"}, {"family": "Scir\u00e8", "given": "Carlo A", "initials": "CA"}, {"family": "Carrara", "given": "Greta", "initials": "G"}, {"family": "Hachulla", "given": "Eric", "initials": "E"}, {"family": "Richez", "given": "Christophe", "initials": "C"}, {"family": "Cacoub", "given": "Patrice", "initials": "P"}, {"family": "Thomas", "given": "Thierry", "initials": "T"}, {"family": "Santos", "given": "Maria J", "initials": "MJ"}, {"family": "Bernardes", "given": "Miguel", "initials": "M"}, {"family": "Hasseli", "given": "Rebecca", "initials": "R"}, {"family": "Regierer", "given": "Anne", "initials": "A"}, {"family": "Schulze-Koops", "given": "Hendrik", "initials": "H"}, {"family": "M\u00fcller-Ladner", "given": "Ulf", "initials": "U"}, {"family": "Pons-Estel", "given": "Guillermo", "initials": "G"}, {"family": "Tanten", "given": "Romina", "initials": "R"}, {"family": "Nieto", "given": "Romina E", "initials": "RE"}, {"family": "Pisoni", "given": "Cecilia N", "initials": "CN"}, {"family": "Tissera", "given": "Yohana S", "initials": "YS"}, {"family": "Xavier", "given": "Ricardo", "initials": "R"}, {"family": "Lopes Marques", "given": "Claudia D", "initials": "CD"}, {"family": "Pileggi", "given": "Gecilmara C S", "initials": "GCS"}, {"family": "Robinson", "given": "Philip C", "initials": "PC"}, {"family": "Machado", "given": "Pedro M", "initials": "PM"}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS"}, {"family": "Sufka", "given": "Paul", "initials": "P"}, {"family": "Grainger", "given": "Rebecca", "initials": "R"}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Gore-Massy", "given": "Monique", "initials": "M"}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Yazdany", "given": "Jinoos", "initials": "J"}, {"family": "COVID-19 Global Rheumatology Alliance Registry", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-25", "journal": {"title": "Lancet Rheumatol", "issn": "2665-9913", "issn-l": null}, "abstract": "Differences in the distribution of individual-level clinical risk factors across regions do not fully explain the observed global disparities in COVID-19 outcomes. We aimed to investigate the associations between environmental and societal factors and country-level variations in mortality attributed to COVID-19 among people with rheumatic disease globally.\n\nIn this observational study, we derived individual-level data on adults (aged 18-99 years) with rheumatic disease and a confirmed status of their highest COVID-19 severity level from the COVID-19 Global Rheumatology Alliance (GRA) registry, collected between March 12, 2020, and Aug 27, 2021. Environmental and societal factors were obtained from publicly available sources. The primary endpoint was mortality attributed to COVID-19. We used a multivariable logistic regression to evaluate independent associations between environmental and societal factors and death, after controlling for individual-level risk factors. We used a series of nested mixed-effects models to establish whether environmental and societal factors sufficiently explained country-level variations in death.\n\n14 044 patients from 23 countries were included in the analyses. 10 178 (72\u00b75%) individuals were female and 3866 (27\u00b75%) were male, with a mean age of 54\u00b74 years (SD 15\u00b76). Air pollution (odds ratio 1\u00b710 per 10 \u03bcg/m3 [95% CI 1\u00b701-1\u00b717]; p=0\u00b70105), proportion of the population aged 65 years or older (1\u00b719 per 1% increase [1\u00b710-1\u00b730]; p<0\u00b70001), and population mobility (1\u00b703 per 1% increase in number of visits to grocery and pharmacy stores [1\u00b702-1\u00b705]; p<0\u00b70001 and 1\u00b702 per 1% increase in number of visits to workplaces [1\u00b700-1\u00b703]; p=0\u00b7032) were independently associated with higher odds of mortality. Number of hospital beds (0\u00b794 per 1-unit increase per 1000 people [0\u00b788-1\u00b700]; p=0\u00b7046), human development index (0\u00b765 per 0\u00b71-unit increase [0\u00b744-0\u00b796]; p=0\u00b7032), government response stringency (0\u00b783 per 10-unit increase in containment index [0\u00b774-0\u00b793]; p=0\u00b70018), as well as follow-up time (0\u00b778 per month [0\u00b769-0\u00b788]; p<0\u00b70001) were independently associated with lower odds of mortality. These factors sufficiently explained country-level variations in death attributable to COVID-19 (intraclass correlation coefficient 1\u00b72% [0\u00b71-9\u00b75]; p=0\u00b714).\n\nOur findings highlight the importance of environmental and societal factors as potential explanations of the observed regional disparities in COVID-19 outcomes among people with rheumatic disease and lay foundation for a new research agenda to address these disparities.\n\nAmerican College of Rheumatology and European Alliance of Associations for Rheumatology.", "doi": "10.1016/S2665-9913(22)00192-8", "pmid": "35909441", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2665-9913(22)00192-8"}, {"db": "pmc", "key": "PMC9313519"}], "notes": [], "created": "2022-08-11T12:05:46.825Z", "modified": "2022-08-11T12:05:46.841Z"}, {"entity": "publication", "iuid": "1b953f2643e640a9ac8c200626ce9e13", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b953f2643e640a9ac8c200626ce9e13.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b953f2643e640a9ac8c200626ce9e13"}}, "title": "Substantial impact of mobility restrictions on reducing COVID-19 incidence in Italy in 2020.", "authors": [{"family": "Vinceti", "given": "Marco", "initials": "M", "orcid": "0000-0002-0551-2473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a25953d69dcd4b9bb597385be88340bc.json"}}, {"family": "Balboni", "given": "Erica", "initials": "E"}, {"family": "Rothman", "given": "Kenneth J", "initials": "KJ"}, {"family": "Teggi", "given": "Sergio", "initials": "S"}, {"family": "Bellino", "given": "Stefania", "initials": "S"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Ferrari", "given": "Fabrizio", "initials": "F"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}, {"family": "Filippini", "given": "Tommaso", "initials": "T"}], "type": "journal article", "published": "2022-07-24", "journal": {"title": "J Travel Med", "issn": "1708-8305", "issn-l": null}, "abstract": "Italy was the first country after China to be severely affected by the COVID-19 pandemic, in early 2020. The country responded swiftly to the outbreak with a nationwide two-step lockdown, the first one light, and the second one tight. By analysing 2020 national mobile phone movements, we assessed how lockdown compliance influenced its efficacy.\n\nWe measured individual mobility during the first epidemic wave with mobile phone movements tracked through carrier networks, and related this mobility to daily new SARS-CoV-2 infections, hospital admissions, intensive care admissions and deaths attributed to COVID-19, taking into account reason for travel (work-related or not) and the means of transport.\n\nThe tight lockdown resulted in an 82% reduction in mobility for the entire country and was effective in swiftly curbing the outbreak as indicated by a shorter time-to-peak of all health outcomes, particularly for provinces with the highest mobility reductions and the most intense COVID-19 spread. Reduction of work-related mobility was accompanied by a nearly linear benefit in outbreak containment; work-unrelated movements had a similar effect only for restrictions exceeding 50%. Reduction in mobility by car and by airplane was nearly linearly associated with a decrease in most COVID-19 health outcomes, while for train travel reductions exceeding 55% had no additional beneficial effects. The absence of viral variants and vaccine availability during the study period eliminated confounding from these two sources.\n\nAdherence to the COVID-19 tight lockdown during the first wave in Italy was high and effective in curtailing the outbreak. Any work-related mobility reduction was effective, but only high reductions in work-unrelated mobility restrictions were effective. For train travel, there was a threshold above which no further benefit occurred. These findings could be particular to the spread of SARS-CoV-2, but might also apply to other communicable infections with comparable transmission dynamics.", "doi": "10.1093/jtm/taac081", "pmid": "35876268", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6649390"}], "notes": [], "created": "2022-08-12T08:39:30.176Z", "modified": "2022-08-12T08:39:30.205Z"}, {"entity": "publication", "iuid": "f0fae26f35db4e589c037eedb07353a8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f0fae26f35db4e589c037eedb07353a8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f0fae26f35db4e589c037eedb07353a8"}}, "title": "COVID-19 Vaccination In Autoimmune Diseases (COVAD) Study: Vaccine Safety In Idiopathic Inflammatory Myopathies.", "authors": [{"family": "Gil-Vila", "given": "Albert", "initials": "A"}, {"family": "Naveen", "given": "R", "initials": "R"}, {"family": "Selva-O'Callaghan", "given": "Albert", "initials": "A"}, {"family": "Sen", "given": "Parikshit", "initials": "P"}, {"family": "Nune", "given": "Arvind", "initials": "A"}, {"family": "Gaur", "given": "Prithvi Sanjeevkumar", "initials": "PS"}, {"family": "Gonzalez", "given": "Raquel Ar\u00e0nega", "initials": "RA"}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M"}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V"}, {"family": "Kardes", "given": "Sinan", "initials": "S"}, {"family": "Kim", "given": "Minchul", "initials": "M"}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A"}, {"family": "Milchert", "given": "Marcin", "initials": "M"}, {"family": "Gheita", "given": "Tamer", "initials": "T"}, {"family": "Salim", "given": "Babur", "initials": "B"}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T"}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE"}, {"family": "Parodis", "given": "Ioannis", "initials": "I"}, {"family": "Nikiphorou", "given": "Elena", "initials": "E"}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL"}, {"family": "Chatterjee", "given": "Tulika", "initials": "T"}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L"}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA"}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK"}, {"family": "Ziade", "given": "Nelly", "initials": "N"}, {"family": "Knitza", "given": "Johannes", "initials": "J"}, {"family": "Kuwana", "given": "Masataka", "initials": "M"}, {"family": "Distler", "given": "Oliver", "initials": "O"}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V"}, {"family": "Aggarwal", "given": "Rohit", "initials": "R"}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "COVAD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-23", "journal": {"title": "Muscle Nerve", "issn": "1097-4598", "issn-l": null}, "abstract": "We studied COVID-19 vaccination-related adverse events (ADEs) 7-days post-vaccination in patients with idiopathic inflammatory myopathies (IIMs) and other systemic autoimmune and inflammatory disorders (SAIDs).\n\n7-day vaccine ADEs were collected in an international patient self-reported e-survey. Descriptive statistics and multivariable regression were performed.\n\n10,900 respondents [1227 IIMs; 4640 SAIDs; 5033 healthy controls (HCs), median age 42 (IQR 30-55) years, 74% female, 45% Caucasian, 69% completely vaccinated] were analysed. 76.3% IIMs patients reported minor and 4.6% major ADEs. Patients with active IIMs reported more frequent major [OR 2.7 (1.04-7.3)] and minor [OR 1.5 (1.1-2.2)] ADEs than inactive IIMs. Rashes were more frequent in IIMs [OR-2.3(1.2-4.2)] than HCs. ADEs were not impacted by steroid dose, although hydroxychloroquine and intravenous/subcutaneous immunoglobulins were associated with a higher risk of minor ADEs [OR 1.9 (1.1-3.3), OR 2.2 (1.1-4.3)]. Overall, ADEs were less frequent in inclusion body myositis (IBM) and BNT162b2 (Pfizer) vaccine recipients DISCUSSION: 7-day post-vaccination ADEs were comparable in patients with IIMs, SAIDs, and HCs, except for a higher risk of rashes in IIMs. Patients with DM, active disease may be at higher risk, and IBM patients at lower risk of specific ADEs. Overall, the benefit of preventing severe COVID-19 through vaccination likely outweighs the risk of vaccine-related ADEs Our results may inform future guidelines regarding COVID-19 vaccination in patients with SAIDs, and specifically in IIMs. Studies to evaluate long-term outcomes and disease flares are needed to shed more light on developing future COVID-19 vaccination guidelines. This article is protected by copyright. All rights reserved.", "doi": "10.1002/mus.27681", "pmid": "35869701", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9349921"}], "notes": [], "created": "2022-08-12T08:41:00.315Z", "modified": "2022-08-12T08:41:00.388Z"}, {"entity": "publication", "iuid": "4003a925eb2c466f8c22f00f2ea1dbfd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4003a925eb2c466f8c22f00f2ea1dbfd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4003a925eb2c466f8c22f00f2ea1dbfd"}}, "title": "Development of a Prediction Model for COVID-19 Acute Respiratory Distress Syndrome in Patients With Rheumatic Diseases: Results From the Global Rheumatology Alliance Registry.", "authors": [{"family": "Izadi", "given": "Zara", "initials": "Z", "orcid": "0000-0002-1867-0905", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea11c7b8c33a4535bd66a64954de7cd4.json"}}, {"family": "Gianfrancesco", "given": "Milena A", "initials": "MA", "orcid": "0000-0002-8351-4626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dca9cada1314065ab094be6fc17524e.json"}}, {"family": "Aguirre", "given": "Alfredo", "initials": "A", "orcid": "0000-0001-6999-6297", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b39f93f5d6aa452da23107f8608e5304.json"}}, {"family": "Strangfeld", "given": "Anja", "initials": "A"}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL"}, {"family": "Gossec", "given": "Laure", "initials": "L"}, {"family": "Carmona", "given": "Loreto", "initials": "L"}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S", "orcid": "0000-0002-8611-162X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73b17eb08d984421847f733b7a6a49d4.json"}}, {"family": "Kearsley-Fleet", "given": "Lianne", "initials": "L", "orcid": "0000-0003-0377-1575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9cc64aac266462baf67998b3d49c6f7.json"}}, {"family": "Schaefer", "given": "Martin", "initials": "M", "orcid": "0000-0001-6487-3634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb2c617a7902440eb574fcb1141785ac.json"}}, {"family": "Seet", "given": "Andrea M", "initials": "AM"}, {"family": "Schmajuk", "given": "Gabriela", "initials": "G", "orcid": "0000-0003-2687-5043", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9ea497446e44b87b2169bc6c67fbf38.json"}}, {"family": "Jacobsohn", "given": "Lindsay", "initials": "L"}, {"family": "Katz", "given": "Patricia", "initials": "P", "orcid": "0000-0002-8146-2519", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/142b667a5d2c4a6a87af7c4315130d3b.json"}}, {"family": "Rush", "given": "Stephanie", "initials": "S"}, {"family": "Al-Emadi", "given": "Samar", "initials": "S", "orcid": "0000-0001-7942-4831", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49a627d387d042f7b99d821d9676d0d5.json"}}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA", "orcid": "0000-0002-5556-4618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/192552e5e3d2435799e57111ea84502d.json"}}, {"family": "Hsu", "given": "Tiffany Y-T", "initials": "TY"}, {"family": "Patel", "given": "Naomi J", "initials": "NJ"}, {"family": "Wise", "given": "Leanna", "initials": "L", "orcid": "0000-0002-6172-9474", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a7e415e8715491bb9d0409d4b008443.json"}}, {"family": "Gilbert", "given": "Emily", "initials": "E"}, {"family": "Duarte-Garc\u00eda", "given": "Al\u00ed", "initials": "A", "orcid": "0000-0003-1749-5719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77a5555c1b624ba49ee7c729be2aef95.json"}}, {"family": "Valenzuela-Almada", "given": "Maria O", "initials": "MO"}, {"family": "Ugarte-Gil", "given": "Manuel F", "initials": "MF"}, {"family": "Ribeiro", "given": "Sandra L\u00facia Euz\u00e9bio", "initials": "SLE", "orcid": "0000-0002-4777-8659", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2db6a09138844b1690855b8b44af31ec.json"}}, {"family": "de Oliveira Marinho", "given": "Adriana", "initials": "A"}, {"family": "de Azevedo Valadares", "given": "Lilian David", "initials": "LD"}, {"family": "Giuseppe", "given": "Daniela Di", "initials": "DD"}, {"family": "Hasseli", "given": "Rebecca", "initials": "R"}, {"family": "Richter", "given": "Jutta G", "initials": "JG"}, {"family": "Pfeil", "given": "Alexander", "initials": "A", "orcid": "0000-0002-2709-6685", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a810753de5340c189b577ca7e5f5935.json"}}, {"family": "Schmeiser", "given": "Tim", "initials": "T"}, {"family": "Isnardi", "given": "Carolina A", "initials": "CA"}, {"family": "Reyes Torres", "given": "Alvaro A", "initials": "AA"}, {"family": "Alle", "given": "Gelsomina", "initials": "G"}, {"family": "Saurit", "given": "Ver\u00f3nica", "initials": "V"}, {"family": "Zanetti", "given": "Anna", "initials": "A"}, {"family": "Carrara", "given": "Greta", "initials": "G"}, {"family": "Labreuche", "given": "Julien", "initials": "J"}, {"family": "Barnetche", "given": "Thomas", "initials": "T"}, {"family": "Herasse", "given": "Muriel", "initials": "M"}, {"family": "Plassart", "given": "Samira", "initials": "S"}, {"family": "Santos", "given": "Maria Jos\u00e9", "initials": "MJ", "orcid": "0000-0002-7946-1365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d031d58f434247fd83359ee0c7602db5.json"}}, {"family": "Rodrigues", "given": "Ana Maria", "initials": "AM"}, {"family": "Robinson", "given": "Philip C", "initials": "PC", "orcid": "0000-0002-3156-3418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/950b622d31724172817ccde09902d215.json"}}, {"family": "Machado", "given": "Pedro M", "initials": "PM", "orcid": "0000-0002-8411-7972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef40d1eea57946e4a37d2e92a02a47cd.json"}}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS", "orcid": "0000-0003-0786-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d99dc166f48d4af7b8e46dc999c7444b.json"}}, {"family": "Sufka", "given": "Paul", "initials": "P"}, {"family": "Grainger", "given": "Rebecca", "initials": "R", "orcid": "0000-0001-9201-8678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9d304e9e29a43a5a7a76679c002a876.json"}}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Costello", "given": "Wendy", "initials": "W"}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Yazdany", "given": "Jinoos", "initials": "J", "orcid": "0000-0002-3508-4094", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62bbeb3392ce40d482da768af63f5d54.json"}}, {"family": "Global Rheumatology Alliance Registry", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-22", "journal": {"title": "ACR Open Rheumatol", "issn": "2578-5745", "issn-l": null}, "abstract": "Some patients with rheumatic diseases might be at higher risk for coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS). We aimed to develop a prediction model for COVID-19 ARDS in this population and to create a simple risk score calculator for use in clinical settings.\n\nData were derived from the COVID-19 Global Rheumatology Alliance Registry from March 24, 2020, to May 12, 2021. Seven machine learning classifiers were trained on ARDS outcomes using 83 variables obtained at COVID-19 diagnosis. Predictive performance was assessed in a US test set and was validated in patients from four countries with independent registries using area under the curve (AUC), accuracy, sensitivity, and specificity. A simple risk score calculator was developed using a regression model incorporating the most influential predictors from the best performing classifier.\n\nThe study included 8633 patients from 74 countries, of whom 523 (6%) had ARDS. Gradient boosting had the highest mean AUC (0.78; 95% confidence interval [CI]: 0.67-0.88) and was considered the top performing classifier. Ten predictors were identified as key risk factors and were included in a regression model. The regression model that predicted ARDS with 71% (95% CI: 61%-83%) sensitivity in the test set, and with sensitivities ranging from 61% to 80% in countries with independent registries, was used to develop the risk score calculator.\n\nWe were able to predict ARDS with good sensitivity using information readily available at COVID-19 diagnosis. The proposed risk score calculator has the potential to guide risk stratification for treatments, such as monoclonal antibodies, that have potential to reduce COVID-19 disease progression.", "doi": "10.1002/acr2.11481", "pmid": "35869686", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9350083"}], "notes": [], "created": "2022-08-12T08:41:21.838Z", "modified": "2022-08-12T08:41:22.412Z"}, {"entity": "publication", "iuid": "a1d27599cc614d1faeaa0ad9baf77bcf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a1d27599cc614d1faeaa0ad9baf77bcf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a1d27599cc614d1faeaa0ad9baf77bcf"}}, "title": "Nurses' Experiences of Caring for Patients With Suspected or Confirmed COVID-19 in the Initial Stage of the Pandemic.", "authors": [{"family": "Mattsson", "given": "Janet", "initials": "J"}, {"family": "Hedlund", "given": "Elin", "initials": "E"}, {"family": "George-Svahn", "given": "Lisa", "initials": "L"}, {"family": "Scheers-Andersson", "given": "Elina", "initials": "E"}, {"family": "Mazaheri", "given": "Monir", "initials": "M"}, {"family": "Bj\u00f6rling", "given": "Gunilla", "initials": "G", "orcid": "0000-0003-1445-900X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae42c961332e49a3aca05f09c4a70f27.json"}}], "type": "journal article", "published": "2022-07-21", "journal": {"title": "SAGE Open Nurs", "issn": "2377-9608", "volume": "8", "pages": "23779608221114981", "issn-l": null}, "abstract": "Nursing staff have faced various challenges during the global pandemic of COVID-19 such as nursing shortages. The great number of COVID-19 patients requiring hospitalization placed heavy demands on healthcare staff to maintain patient safety and to work according to constantly changing guidelines to prevent the spread of infection.\n\nThe objective was to describe nurses' experiences of caring for patients with suspected or confirmed COVID-19 in the initial phase of the pandemic.\n\nThe study has a qualitative design. Semi-structured interviews were conducted with seven nurses in primary care and hospital care during the initial stage of the pandemic. Qualitative content analysis with an inductive approach was used.\n\nThe nurses expressed that the working routines changed very quickly at the onset of the pandemic. A triage system was implemented to care for patients with symptoms of COVID-19 to prevent transmission between patients. A major change was the constant use of personal protective equipment in patient care. The nurses also experienced a sense of inadequacy regarding the care of the patients and became emotionally affected and exhausted.\n\nThe nurses experienced that many patients worsened clinically, leading to exhausting and difficult nursing care situations. They also experienced increasing responsibility since new protective equipment and procedures needed to be quickly implemented according to frequently changing recommendations, causing the nurses to feel uncertain about how to maintain patient safety. Support from colleagues was crucial to cope throughout the initial stage of the pandemic.", "doi": "10.1177/23779608221114981", "pmid": "35899037", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1177_23779608221114981"}, {"db": "pmc", "key": "PMC9310289"}], "notes": [], "created": "2022-08-12T08:33:56.133Z", "modified": "2022-08-12T08:33:56.186Z"}, {"entity": "publication", "iuid": "a011e37c6ff0437495b432ae29271bdf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a011e37c6ff0437495b432ae29271bdf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a011e37c6ff0437495b432ae29271bdf"}}, "title": "Correction to: Persisting Salivary IgG Against SARS-CoV-2 at 9 Months After Mild COVID-19: A Complementary Approach to Population Surveys.", "authors": [{"family": "Alkharaan", "given": "Hassan", "initials": "H"}, {"family": "Bayati", "given": "Shaghayegh", "initials": "S"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Olsson", "given": "Annika", "initials": "A"}, {"family": "Lindahl", "given": "Karin", "initials": "K"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "Tsilingaridis", "given": "Georgios", "initials": "G"}, {"family": "De Palma", "given": "Patricia", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M", "orcid": "0000-0002-3793-4064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4bc179656eb442f9ac9dc72c8c6841d.json"}}], "type": "published erratum", "published": "2022-07-21", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899"}, "abstract": null, "doi": "10.1093/infdis/jiac121", "pmid": "35859351", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "6647598"}], "notes": [], "created": "2022-08-12T08:42:51.642Z", "modified": "2022-08-12T08:43:07.903Z"}, {"entity": "publication", "iuid": "f1bc151cf7c44c80bb8c06fbbb08d26e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1bc151cf7c44c80bb8c06fbbb08d26e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1bc151cf7c44c80bb8c06fbbb08d26e"}}, "title": "Intrapulmonary Bronchopulmonary Anastomoses in Severe COVID-19-related Acute Respiratory Failure.", "authors": [{"family": "Bodmer", "given": "Jenna", "initials": "J", "orcid": "0000-0003-3110-6679", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4a89b7b5ac7474899be9ef2b0762306.json"}}, {"family": "Levin", "given": "Alice", "initials": "A"}, {"family": "West\u00f6\u00f6", "given": "Christian", "initials": "C"}, {"family": "van der Have", "given": "Oscar", "initials": "O", "orcid": "0000-0003-4726-0697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/120c66dfee0349df981dbe1dff391e8f.json"}}, {"family": "Peruzzi", "given": "Niccol\u00f2", "initials": "N"}, {"family": "Tran-Lundmark", "given": "Karin", "initials": "K"}, {"family": "Abman", "given": "Steven H", "initials": "SH", "orcid": "0000-0002-7292-2085", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/236683b5bd3f4cc6ad63453734a23185.json"}}, {"family": "Galambos", "given": "Csaba", "initials": "C"}], "type": "journal article", "published": "2022-07-20", "journal": {"title": "Am J Respir Crit Care Med", "issn": "1535-4970", "issn-l": "1073-449X"}, "abstract": null, "doi": "10.1164/rccm.202205-0922LE", "pmid": "35857856", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2022-08-12T08:46:06.359Z", "modified": "2022-08-12T08:46:36.162Z"}, {"entity": "publication", "iuid": "236664e051fe44f2a7a3daf4b7131667", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/236664e051fe44f2a7a3daf4b7131667.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/236664e051fe44f2a7a3daf4b7131667"}}, "title": "Compliance with Health Recommendations and Vaccine Hesitancy During the COVID Pandemic in Nine Countries.", "authors": [{"family": "Lansford", "given": "Jennifer E", "initials": "JE", "orcid": "0000-0003-1956-4917", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/099f957450e743acab538878cc487a27.json"}}, {"family": "Rothenberg", "given": "W Andrew", "initials": "WA"}, {"family": "Yotanyamaneewong", "given": "Saengduean", "initials": "S"}, {"family": "Alampay", "given": "Liane Pe\u00f1a", "initials": "LP"}, {"family": "Al-Hassan", "given": "Suha M", "initials": "SM"}, {"family": "Bacchini", "given": "Dario", "initials": "D"}, {"family": "Bornstein", "given": "Marc H", "initials": "MH"}, {"family": "Chang", "given": "Lei", "initials": "L"}, {"family": "Deater-Deckard", "given": "Kirby", "initials": "K"}, {"family": "Di Giunta", "given": "Laura", "initials": "L"}, {"family": "Dodge", "given": "Kenneth A", "initials": "KA"}, {"family": "Gurdal", "given": "Sevtap", "initials": "S"}, {"family": "Liu", "given": "Qin", "initials": "Q"}, {"family": "Long", "given": "Qian", "initials": "Q"}, {"family": "Morgenstern", "given": "Glen", "initials": "G"}, {"family": "Oburu", "given": "Paul", "initials": "P"}, {"family": "Pastorelli", "given": "Concetta", "initials": "C"}, {"family": "Skinner", "given": "Ann T", "initials": "AT"}, {"family": "Sorbring", "given": "Emma", "initials": "E"}, {"family": "Tapanya", "given": "Sombat", "initials": "S"}, {"family": "Steinberg", "given": "Laurence", "initials": "L"}, {"family": "Uribe Tirado", "given": "Liliana Maria", "initials": "LM"}], "type": "journal article", "published": "2022-07-20", "journal": {"title": "Prev Sci", "issn": "1573-6695", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Longitudinal data from the Parenting Across Cultures study of children, mothers, and fathers in 12 cultural groups in nine countries (China, Colombia, Italy, Jordan, Kenya, the Philippines, Sweden, Thailand, and the USA; N = 1331 families) were used to understand predictors of compliance with COVID-19 mitigation strategies and vaccine hesitancy. Confidence in government responses to the COVID pandemic was also examined as a potential moderator of links between pre-COVID risk factors and compliance with COVID mitigation strategies and vaccine hesitancy. Greater confidence in government responses to the COVID pandemic was associated with greater compliance with COVID mitigation strategies and less vaccine hesitancy across cultures and reporters. Pre-COVID financial strain and family stress were less consistent predictors of compliance with COVID mitigation strategies and vaccine hesitancy than confidence in government responses to the pandemic. Findings suggest the importance of bolstering confidence in government responses to future human ecosystem disruptions, perhaps through consistent, clear, non-partisan messaging and transparency in acknowledging limitations and admitting mistakes to inspire compliance with government and public health recommendations.", "doi": "10.1007/s11121-022-01399-9", "pmid": "35857257", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11121-022-01399-9"}], "notes": [], "created": "2022-08-12T08:46:57.085Z", "modified": "2022-08-12T08:47:32.154Z"}, {"entity": "publication", "iuid": "6dcf04f2676e49fcb47b08767d4c064a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6dcf04f2676e49fcb47b08767d4c064a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6dcf04f2676e49fcb47b08767d4c064a"}}, "title": "\"The New Educational Project TELEVASCULAR GAMES During COVID-19 Pandemic.\"", "authors": [{"family": "Chisci", "given": "Emiliano", "initials": "E"}, {"family": "Parlani", "given": "Gianbattista", "initials": "G"}, {"family": "Gatta", "given": "Emanuele", "initials": "E"}, {"family": "Isernia", "given": "Giacomo", "initials": "G"}, {"family": "de Donato", "given": "Gianmarco", "initials": "G"}, {"family": "Antonello", "given": "Michele", "initials": "M"}, {"family": "Simonte", "given": "Gioele", "initials": "G"}, {"family": "K\u00f6lbel", "given": "Tilo", "initials": "T"}, {"family": "Bertoglio", "given": "Luca", "initials": "L"}, {"family": "Yeung", "given": "Kak Khee", "initials": "KK"}, {"family": "Donas", "given": "Konstantinos", "initials": "K"}, {"family": "Fazzini", "given": "Stefano", "initials": "S"}, {"family": "Dias", "given": "Nuno", "initials": "N"}, {"family": "Michelagnoli", "given": "Stefano", "initials": "S"}, {"family": "Televascolare Games Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-20", "journal": {"title": "J Vasc Surg Cases Innov Tech", "issn": "2468-4287", "issn-l": null}, "abstract": "To report methodology and first-year results of a new educational project called \"Televascular Games\", which took place during COVID-19 pandemic.\n\nComplex aneurysmal aortic disease was discussed during a 2-hour competition webinar, according to three modalities. 1) Planning case competition (PCC): 2-4 pre-operative Computed Tomography Angiography (CTA) scans of an already performed selected case were submitted for the competition. CTA-scans were anonymously uploaded, without any reference to the center or the surgeon who performed the case. The competitor had to prepare a presentation of how he/she would have diagnosed, sized, planned, treated and followed up the case, of the medical therapy and of the bail-out maneuvers. 2) Challenging case competition (CCC): the competitor elaborates a presentation of an already treated case concerning an aortic topic and discusses sizing, planning, treatment, possible bail-out maneuvers and obtained results. For the CCC and PCC, the competitors with the best score were pre-selected to present and discuss their plan during the webinars. 3) Quiz competition (QZ): 2-6 angio-CTA scans of already performed selected aortic cases were submitted for the competition. A quiz with multiple-choice questions was answered by the competitors. The top four competitors were selected for the webinars and then they discussed the cases during the webinar. Finally, at the end of the case-discussion, the effective case resolution and follow-up were shown. A final winner was voted via televoting, based on six pre-established criteria. The project was endorsed by different National and International Societies.\n\nBetween October-2020 and December-2021, there were 12 Italian and 1 international webinars with overall 1695 participants (mean 130, range:86-177). Competitors were 54 (mean age 27, range 22-38 years). Two editions were CCCs, two QZs, and nine PCCs. The reliability of the inter-observer sizing of competitors was k=.43 and k=.62 for the proximal and distal sealing measurements respectively and very good (k =.88-.95) in the evaluation of orientation of the vessels, presence of angulations, calcifications and thrombus. The sizing discrepancy resulted in a significant variability of the planning (k=.45). The project ranked 9.6 in a \"10-point\" rating scale by all the participants and competitors.\n\nThe formula of gaming and collegial discussion of aortic cases herein reported has proved valid and attractive during COVID-19 pandemic period. The variability of the results on sizing and planning suggested to confer with a second opinion especially for less experienced surgeons.", "doi": "10.1016/j.jvscit.2022.05.019", "pmid": "35873717", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2468-4287(22)00109-5"}, {"db": "pmc", "key": "PMC9296369"}], "notes": [], "created": "2022-08-12T08:40:33.491Z", "modified": "2022-08-12T08:40:33.519Z"}, {"entity": "publication", "iuid": "5c00b8b46bf74290a4762e8d234a03c1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c00b8b46bf74290a4762e8d234a03c1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c00b8b46bf74290a4762e8d234a03c1"}}, "title": "Methodological guidance for incorporating equity when informing rapid-policy and guideline development.", "authors": [{"family": "Dewidar", "given": "Omar", "initials": "O"}, {"family": "Kawala", "given": "Brenda Allen", "initials": "BA"}, {"family": "Antequera", "given": "Alba", "initials": "A"}, {"family": "Tricco", "given": "Andrea C", "initials": "AC"}, {"family": "Tovey", "given": "David", "initials": "D"}, {"family": "Straus", "given": "Sharon", "initials": "S"}, {"family": "Glover", "given": "Rebecca", "initials": "R"}, {"family": "Tufte", "given": "Janice", "initials": "J"}, {"family": "Magwood", "given": "Olivia", "initials": "O"}, {"family": "Smith", "given": "Maureen", "initials": "M"}, {"family": "Ooi", "given": "Cheow Peng", "initials": "CP"}, {"family": "Dion", "given": "Anna", "initials": "A"}, {"family": "Goetghebeur", "given": "Mireille", "initials": "M"}, {"family": "Reveiz", "given": "Ludovic", "initials": "L"}, {"family": "Negrini", "given": "Stefano", "initials": "S"}, {"family": "Tugwell", "given": "Peter", "initials": "P"}, {"family": "Petkovic", "given": "Jennifer", "initials": "J"}, {"family": "Welch", "given": "Vivian", "initials": "V"}, {"family": "COVID-END Equity Task Force", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-19", "journal": {"title": "J Clin Epidemiol", "issn": "1878-5921", "issn-l": null, "volume": "150", "issue": null, "pages": "142-153"}, "abstract": "We provide guidance for considering equity in rapid reviews through examples of published COVID-19 rapid reviews.\r\n\r\nThis guidance was developed based on a series of methodological meetings, review of internationally renowned guidance such as the Cochrane Handbook and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis for equity-focused systematic reviews (PRISMA-Equity) guideline. We identified Exemplar rapid reviews by searching COVID-19 databases and requesting examples from our team.\r\n\r\nWe proposed the following key steps: 1. involve relevant stakeholders with lived experience in the conduct and design of the review; 2. reflect on equity, inclusion and privilege in team values and composition; 3. develop research question to assess health inequities; 4. conduct searches in relevant disciplinary databases; 5. collect data and critically appraise recruitment, retention and attrition for populations experiencing inequities; 6. analyse evidence on equity; 7. evaluate the applicability of findings to populations experiencing inequities; and 8. adhere to reporting guidelines for communicating review findings. We illustrated these methods through rapid review examples.\r\n\r\nImplementing this guidance could contribute to improving equity considerations in rapid reviews produced in public health emergencies, and help policymakers better understand the distributional impact of diseases on the population.", "doi": "10.1016/j.jclinepi.2022.07.007", "pmid": "35863618", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0895-4356(22)00180-9"}, {"db": "pmc", "key": "PMC9359903"}], "notes": [], "created": "2022-08-12T08:42:08.653Z", "modified": "2022-11-09T08:37:56.301Z"}, {"entity": "publication", "iuid": "1d5ba17b4bf44ac89c3e293f7263ad7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d5ba17b4bf44ac89c3e293f7263ad7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d5ba17b4bf44ac89c3e293f7263ad7a"}}, "title": "Mental health in individuals with self-reported psychiatric symptoms during the COVID-19 pandemic: Baseline data from a swedish longitudinal cohort study.", "authors": [{"family": "Rozental", "given": "Alexander", "initials": "A"}, {"family": "S\u00f6rman", "given": "Karolina", "initials": "K"}, {"family": "Ojala", "given": "Olivia", "initials": "O"}, {"family": "Jangard", "given": "Simon", "initials": "S"}, {"family": "El Alaoui", "given": "Samir", "initials": "S"}, {"family": "M\u00e5nsson", "given": "Kristoffer N T", "initials": "KNT"}, {"family": "Shahnavaz", "given": "Shervin", "initials": "S"}, {"family": "Lundin", "given": "Johan", "initials": "J"}, {"family": "Forsstr\u00f6m", "given": "David", "initials": "D"}, {"family": "Hedman-Lagerl\u00f6f", "given": "Maria", "initials": "M"}, {"family": "Lundgren", "given": "Tobias", "initials": "T"}, {"family": "Jayaram-Lindstr\u00f6m", "given": "Nitya", "initials": "N"}], "type": "journal article", "published": "2022-07-19", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "13", "pages": "933858", "issn-l": "1664-0640"}, "abstract": "Individuals with psychiatric disorders may be both vulnerable and sensitive to rapid societal changes that have occurred during the COVID-19 pandemic. To fully understand these impacts, repeated measurements of these individuals are warranted. The current longitudinal study set out to perform monthly assessment of individuals with common psychiatric disorders using established questionnaires with a possibility for them to self- rate their symptoms, over time.\n\nRecruitment of individuals who identified themselves as struggling with mental health problems, living in Sweden between July 2020 and June 2021 using an online survey. The individuals answered questions on demographics, psychiatric history, current psychiatric symptoms (e.g., Patient Health Questionnaire, PHQ-9; General Anxiety Disorder, GAD-7), somatic health, health-care contacts and any changes therein during the pandemic. Monthly, longitudinal assessments are still ongoing (consenting participants provide data for 1 year), and here we present descriptive statistics from the baseline measurement. All measurements from baseline (>400 items), and follow-ups are presented in detail.\n\nA total of 6.095 participants (average age 35 years) submitted complete baseline data. Marital status (43% single) and number of years of education (48% highest degree being high school) were evenly distributed in this population. The most common lifetime psychiatric disorder in the sample was depressive disorder (80.5%) and generalized anxiety disorder (45.9%), with a substantial proportion having severe symptoms of depression. (30.5%) and anxiety (37.1%). Lifetime suicidal ideation (75.0%) and non-suicidal self-harm (57.7%) were prevalent in the group and 14.5% reported drug use during the pandemic. Allergies (36.8%) were the most common somatic condition, followed by irritable bowel syndrome (18.7%). For those having experienced a traumatic event, 39% showed symptoms during the pandemic indicating PTSD. Regarding contact with mental health services during the pandemic, 22% had established a new contact, and 20% reported to have increased their psychiatric medication compared to before the pandemic.\n\nBaseline data collected during the pandemic from individuals in Sweden with pre-existing psychiatric disorders demonstrate that this sample represents a population suitable for an investigation on the long-term impact of the pandemic, as intended by the longitudinal investigation that is ongoing. Follow-up questionnaires over a 12-month period are being collected and will indicate how the health and well-being of this population was impacted during the changes and uncertainties that have been characteristic of the past 2 years.", "doi": "10.3389/fpsyt.2022.933858", "pmid": "35928773", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9343700"}], "notes": [], "created": "2022-08-11T11:59:59.748Z", "modified": "2022-08-11T11:59:59.764Z"}, {"entity": "publication", "iuid": "810ac4db03734d8891c68503f07daaf2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/810ac4db03734d8891c68503f07daaf2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/810ac4db03734d8891c68503f07daaf2"}}, "title": "Abrupt decreases in infectivity of SARS-CoV-2 in aerosols.", "authors": [{"family": "L\u00f6ndahl", "given": "Jakob", "initials": "J", "orcid": "0000-0001-9379-592X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7648041474a8469aa54218ca177e4c19.json"}}, {"family": "Alsved", "given": "Malin", "initials": "M"}], "type": "journal article", "published": "2022-07-19", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "119", "issue": "29", "pages": "e2208742119", "issn-l": "0027-8424"}, "abstract": null, "doi": "10.1073/pnas.2208742119", "pmid": "35858364", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9304013"}], "notes": [], "created": "2022-08-12T08:45:44.880Z", "modified": "2022-08-12T08:45:44.931Z"}, {"entity": "publication", "iuid": "733f8a5c26e7460db9284901482c7bd9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/733f8a5c26e7460db9284901482c7bd9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/733f8a5c26e7460db9284901482c7bd9"}}, "title": "The effect of herd immunity thresholds on willingness to vaccinate.", "authors": [{"family": "Andersson", "given": "Per A", "initials": "PA", "orcid": "0000-0001-7445-2008", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1fa117de5f540b7a5f13f97803c46b3.json"}}, {"family": "Tingh\u00f6g", "given": "Gustav", "initials": "G", "orcid": "0000-0002-8159-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c4dcebfe7b0425182298cf35259223c.json"}}, {"family": "V\u00e4stfj\u00e4ll", "given": "Daniel", "initials": "D", "orcid": "0000-0003-2873-4500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebf69c8715ab4141a7b06a20d94ca666.json"}}], "type": "journal article", "published": "2022-07-18", "journal": {"title": "Humanit Soc Sci Commun", "issn": "2662-9992", "volume": "9", "issue": "1", "pages": "243", "issn-l": null}, "abstract": "Throughout the COVID-19 pandemic, media and policymakers openly speculated about the number of immune citizens needed to reach a herd immunity threshold. What are the effects of such numerical goals on the willingness to vaccinate? In a large representative sample (N = 1540) of unvaccinated Swedish citizens, we find that giving a low (60%) compared to a high (90%) threshold has direct effects on beliefs about reaching herd immunity and beliefs about how many others that will get vaccinated. Presenting the high threshold makes people believe that herd immunity is harder to reach (on average about half a step on a seven-point scale), compared to the low threshold. Yet at the same time, people also believe that a higher number of the population will get vaccinated (on average about 3.3% more of the population). Since these beliefs affect willingness to vaccinate in opposite directions, some individuals are encouraged and others discouraged depending on the threshold presented. Specifically, in mediation analysis, the high threshold indirectly increases vaccination willingness through the belief that many others will get vaccinated (B = 0.027, p = 0.003). At the same time, the high threshold also decreases vaccination willingness through the belief that the threshold goal is less attainable (B = -0.053, p < 0.001) compared to the low threshold condition. This has consequences for ongoing COVID-19 vaccination and future vaccination campaigns. One message may not fit all, as different groups can be encouraged or discouraged from vaccination.", "doi": "10.1057/s41599-022-01257-7", "pmid": "35874284", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "1257"}, {"db": "pmc", "key": "PMC9294790"}], "notes": [], "created": "2022-08-12T08:40:09.826Z", "modified": "2022-08-12T08:40:09.921Z"}, {"entity": "publication", "iuid": "d7be028906b54732b7f52b626b93497c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d7be028906b54732b7f52b626b93497c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d7be028906b54732b7f52b626b93497c"}}, "title": "Following a healthy/balanced diet predicts lower anxiety and depression during the COVID-19 pandemic.", "authors": [{"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Fortea", "given": "Lydia", "initials": "L"}, {"family": "Pomarol-Clotet", "given": "Edith", "initials": "E"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Fullana", "given": "Miquel \u00c0ngel", "initials": "M\u00c0"}, {"family": "Solanes", "given": "Aleix", "initials": "A"}], "type": "case reports", "published": "2022-07-16", "journal": {"title": "Rev Psiquiatr Salud Ment (Engl Ed)", "issn": "2173-5050", "volume": "15", "issue": "2", "pages": "147-149", "issn-l": null}, "abstract": null, "doi": "10.1016/j.rpsmen.2022.07.003", "pmid": "35840282", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2173-5050(22)00027-9"}, {"db": "pmc", "key": "PMC9274263"}], "notes": [], "created": "2022-08-12T08:55:27.745Z", "modified": "2022-08-12T08:55:27.771Z"}, {"entity": "publication", "iuid": "2679a2dabc50490c856836088dddbab2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2679a2dabc50490c856836088dddbab2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2679a2dabc50490c856836088dddbab2"}}, "title": "Updated SIOG COVID-19 working group recommendations on COVID-19 vaccination among older adults with cancer.", "authors": [{"family": "Soto-Perez-de-Celis", "given": "Enrique", "initials": "E"}, {"family": "Mislang", "given": "Anna Rachelle", "initials": "AR"}, {"family": "Hern\u00e1ndez-Favela", "given": "Celia Gabriela", "initials": "CG"}, {"family": "Russo", "given": "Chiara", "initials": "C"}, {"family": "Colloca", "given": "Giuseppe", "initials": "G"}, {"family": "Williams", "given": "Grant R", "initials": "GR"}, {"family": "O'Hanlon", "given": "Shane", "initials": "S"}, {"family": "Cooper", "given": "Lisa", "initials": "L"}, {"family": "O'Donovan", "given": "Anita", "initials": "A"}, {"family": "Audisio", "given": "Riccardo A", "initials": "RA"}, {"family": "Cheung", "given": "Kwok-Leung", "initials": "KL"}, {"family": "Giron\u00e9s-Sarri\u00f3", "given": "Regina", "initials": "R"}, {"family": "Stauder", "given": "Reinhard", "initials": "R"}, {"family": "Jaklitsch", "given": "Michael", "initials": "M"}, {"family": "Cairo", "given": "Clarito", "initials": "C"}, {"family": "Gil", "given": "Luiz Antonio", "initials": "LA"}, {"family": "Alam", "given": "Mahmood", "initials": "M"}, {"family": "Sattar", "given": "Schroder", "initials": "S"}, {"family": "Kantilal", "given": "Kumud", "initials": "K"}, {"family": "Loh", "given": "Kah Poh", "initials": "KP"}, {"family": "Lichtman", "given": "Stuart M", "initials": "SM"}, {"family": "Brain", "given": "Etienne", "initials": "E"}, {"family": "Wildiers", "given": "Hans", "initials": "H"}, {"family": "Kanesvaran", "given": "Ravindran", "initials": "R"}, {"family": "Battisti", "given": "Nicol\u00f2 Matteo Luca", "initials": "NML"}], "type": "journal article", "published": "2022-07-15", "journal": {"title": "J Geriatr Oncol", "issn": "1879-4076", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jgo.2022.07.005", "pmid": "35853816", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1879-4068(22)00171-0"}, {"db": "pmc", "key": "PMC9283597"}], "notes": [], "created": "2022-08-12T08:49:28.874Z", "modified": "2022-08-12T08:49:28.879Z"}, {"entity": "publication", "iuid": "af44170e42fc454098218a59502ac0ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/af44170e42fc454098218a59502ac0ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/af44170e42fc454098218a59502ac0ef"}}, "title": "Oral manifestations in young adults infected with COVID-19 and impact of smoking: a multi-country cross-sectional study.", "authors": [{"family": "El Tantawi", "given": "Maha", "initials": "M", "orcid": "0000-0003-4989-6584", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b0b3508a71b54068bbfd0a3362541960.json"}}, {"family": "Sabbagh", "given": "Heba Jafar", "initials": "HJ"}, {"family": "Alkhateeb", "given": "Nada Abubakor", "initials": "NA"}, {"family": "Quritum", "given": "Maryam", "initials": "M"}, {"family": "Abourdan", "given": "Joud", "initials": "J"}, {"family": "Qureshi", "given": "Nafeesa", "initials": "N"}, {"family": "Qureshi", "given": "Shabnum", "initials": "S"}, {"family": "Hamoud", "given": "Ahmed", "initials": "A"}, {"family": "Mahmoud", "given": "Nada", "initials": "N"}, {"family": "Odeh", "given": "Ruba", "initials": "R"}, {"family": "Al-Khanati", "given": "Nuraldeen Maher", "initials": "NM"}, {"family": "Jaber", "given": "Rawiah", "initials": "R"}, {"family": "Balkhoyor", "given": "Abdulrahman Loaie", "initials": "AL"}, {"family": "Shabi", "given": "Mohammed", "initials": "M"}, {"family": "Folayan", "given": "Morenike O", "initials": "MO", "orcid": "0000-0002-9008-7730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f05ff9524108435d8c181463693f988e.json"}}, {"family": "Gomaa", "given": "Noha", "initials": "N"}, {"family": "Al Nahdi", "given": "Raqiya", "initials": "R"}, {"family": "Mahmoud", "given": "Nawal", "initials": "N"}, {"family": "El Wazziki", "given": "Hanane", "initials": "H"}, {"family": "Alnaas", "given": "Manal", "initials": "M"}, {"family": "Samodien", "given": "Bahia", "initials": "B"}, {"family": "Mahmoud", "given": "Rawa", "initials": "R"}, {"family": "Abu Assab", "given": "Nour", "initials": "N"}, {"family": "Saad", "given": "Sherin", "initials": "S"}, {"family": "Al-Hachim", "given": "Sondos", "initials": "S"}, {"family": "Alshaikh", "given": "Ali", "initials": "A"}, {"family": "Abdelaziz", "given": "Wafaa", "initials": "W"}], "type": "journal article", "published": "2022-07-15", "journal": {"title": "PeerJ", "issn": "2167-8359", "volume": "10", "pages": "e13555", "issn-l": "2167-8359"}, "abstract": "Oral manifestations and lesions could adversely impact the quality of people's lives. COVID-19 infection may interact with smoking and the impact on oral manifestations is yet to be discovered.\n\nThe aim of this study was to assess the self-reported presence of oral lesions by COVID-19-infected young adults and the differences in the association between oral lesions and COVID-19 infection in smokers and non-smokers.\n\nThis cross-sectional multi-country study recruited 18-to-23-year-old adults. A validated questionnaire was used to collect data on COVID-19-infection status, smoking and the presence of oral lesions (dry mouth, change in taste, and others) using an online platform. Multi-level logistic regression was used to assess the associations between the oral lesions and COVID-19 infection; the modifying effect of smoking on the associations.\n\nData was available from 5,342 respondents from 43 countries. Of these, 8.1% reported COVID-19-infection, 42.7% had oral manifestations and 12.3% were smokers. A significantly greater percentage of participants with COVID-19-infection reported dry mouth and change in taste than non-infected participants. Dry mouth (AOR=, 9=xxx) and changed taste (AOR=, 9=xxx) were associated with COVID-19- infection. The association between COVID-19-infection and dry mouth was stronger among smokers than non-smokers (AOR = 1.26 and 1.03, p = 0.09) while the association with change in taste was stronger among non-smokers (AOR = 1.22 and 1.13, p = 0.86).\n\nDry mouth and changed taste may be used as an indicator for COVID-19 infection in low COVID-19-testing environments. Smoking may modify the association between some oral lesions and COVID-19-infection.", "doi": "10.7717/peerj.13555", "pmid": "35860046", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "13555"}, {"db": "pmc", "key": "PMC9291069"}], "notes": [], "created": "2022-08-12T08:42:26.739Z", "modified": "2022-08-12T08:42:26.838Z"}, {"entity": "publication", "iuid": "0d9ee7903d15472dba9fe4a6d94c737d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d9ee7903d15472dba9fe4a6d94c737d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d9ee7903d15472dba9fe4a6d94c737d"}}, "title": "Immigrant background and socioeconomic status are associated with severe COVID-19 requiring intensive care.", "authors": [{"family": "Nordberg", "given": "Per", "initials": "P"}, {"family": "Jonsson", "given": "Martin", "initials": "M"}, {"family": "Hollenberg", "given": "Jacob", "initials": "J"}, {"family": "Ringh", "given": "Mattias", "initials": "M"}, {"family": "Kiiski Berggren", "given": "Ritva", "initials": "R"}, {"family": "Hofmann", "given": "Robin", "initials": "R"}, {"family": "Svensson", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2022-07-15", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "12133", "issn-l": "2045-2322"}, "abstract": "To determine whether immigrant background and socioeconomic status were associated with increased risk to develop severe Coronavirus disease 2019 (COVID-19) requiring mechanical ventilation at the intensive care unit and to study their effects on 90-day mortality. Nationwide case-control study with personal-level data from the Swedish Intensive Care register linked with socioeconomic data from Statistics Sweden and comorbidity data from the national patient register. For each case of COVID-19 treated with mechanical ventilation at the intensive care unit (outcome), 10 population controls were matched for age, sex and area of residence. Logistic and Cox regression were used to study the association between the exposure (immigrant background, income and educational level) and 90-day mortality. In total, 4 921 cases and 49 210 controls were matched. In the adjusted model, the risk of severe COVID-19 was highest in individuals born in Asia (Odds ratio [OR] = 2.44, 95% confidence interval [CI] = 2.20-2.69), South America (OR = 2.34, 95% CI = 1.82-2.98) and Africa (OR = 2.11, 95% CI = 1.76-2.50). Post-secondary education was associated with a lower risk of severe COVID-19 (OR = 0.75, CI = 0.69-0.82) as was the highest (vs. lowest) income quintile (OR = 0.87, CI = 0.77-0.97). In the fully adjusted Cox-regression analysis birth region of Africa (OR 1.38, CI = 1.03-1.86) and high income (OR 0.75, CI 0.63-0.89) were associated with 90-day mortality. Immigrant background, educational level and income were independently associated with acquiring severe COVID-19 with need for mechanical ventilation.", "doi": "10.1038/s41598-022-15884-2", "pmid": "35840691", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-15884-2"}, {"db": "pmc", "key": "PMC9285186"}], "notes": [], "created": "2022-08-12T08:55:10.836Z", "modified": "2022-08-12T08:55:10.842Z"}, {"entity": "publication", "iuid": "dda4e2f7fa5a492b99c23d4aa742a141", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dda4e2f7fa5a492b99c23d4aa742a141.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dda4e2f7fa5a492b99c23d4aa742a141"}}, "title": "Correction: Evaluation of science advice during the COVID-19 pandemic in Sweden.", "authors": [{"family": "Brusselaers", "given": "Nele", "initials": "N", "orcid": "0000-0003-0137-447X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8a4e9c84a5843c18e95fe0becb19506.json"}}, {"family": "Steadson", "given": "David", "initials": "D", "orcid": "0000-0003-3063-3880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce74e24664974b86943dcc03ba277cd4.json"}}, {"family": "Bjorklund", "given": "Kelly", "initials": "K"}, {"family": "Breland", "given": "Sofia", "initials": "S"}, {"family": "Stilhoff S\u00f6rensen", "given": "Jens", "initials": "J"}, {"family": "Ewing", "given": "Andrew", "initials": "A"}, {"family": "Bergmann", "given": "Sigurd", "initials": "S"}, {"family": "Steineck", "given": "Gunnar", "initials": "G"}], "type": "published erratum", "published": "2022-07-15", "journal": {"title": "Humanit Soc Sci Commun", "issn": "2662-9992", "volume": "9", "issue": "1", "pages": "239", "issn-l": null}, "abstract": "[This corrects the article DOI: 10.1057/s41599-022-01097-5.].", "doi": "10.1057/s41599-022-01254-w", "pmid": "35856700", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "1254"}, {"db": "pmc", "key": "PMC9284503"}], "notes": [], "created": "2022-08-12T08:47:40.670Z", "modified": "2022-08-12T08:47:50.453Z"}, {"entity": "publication", "iuid": "a8ba104875974e309f4d9950c3d67514", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8ba104875974e309f4d9950c3d67514.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8ba104875974e309f4d9950c3d67514"}}, "title": "Cognitive Behavioral Therapy and Acceptance and Commitment Therapy (CBT-ACT) vs. Standard Care After Critical Illness Due to COVID-19: Protocol for a Pilot Randomized Controlled Trial.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Lidin-Darlington", "given": "Pernilla", "initials": "P"}, {"family": "Lilja", "given": "Gisela", "initials": "G"}, {"family": "Nilsson", "given": "Anna", "initials": "A"}, {"family": "Schandl", "given": "Anna", "initials": "A"}, {"family": "Friberg", "given": "Hans", "initials": "H"}], "type": "journal article", "published": "2022-07-15", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "13", "pages": "907215", "issn-l": "1664-0640"}, "abstract": "Post-covid syndrome is an emerging condition involving a wide range of symptoms, including high rates of poor mental health. The diagnostic relevance and clinical severity of these symptoms are largely unknown, and evidence for treatment of post-covid mental health symptoms is lacking. This protocol describes a pilot randomized clinical trial, primarily aiming to assess feasibility, participant adherence and satisfaction in a novel phycho-therapeutic intervention on post-covid anxiety and depression symptoms \u22651 year after critically ill COVID-19. Whether the intervention may generate improvements in post-covid depression, anxiety, post-traumatic stress and health-related quality of life (HRQoL) will be addressed in a following larger trial.\n\nA multicenter, investigator-initiated randomized controlled trial (Clinical Trial Identifier number NCT05119608) including Intensive Care Unit (ICU)-treated COVID-19 survivors, who display symptoms of anxiety and/or depression at follow-up 12 months after hospitalization (Hospital Anxiety and Depression Scale \u22658 for depression or anxiety). Eligible individuals are referred to a psychiatrist for structured diagnostic assessment and inclusion in the trial. Participants will be randomized to either a 10-week cognitive behavioral therapy intervention with added acceptance and commitment therapy (CBT-ACT) or standard care (primary care referral). Primary study outcome measure is feasibility and patient adherence, defined as the proportion of participants who consent to randomization and remain in the study including follow-up. Secondary outcome measures include reduced symptoms in the HADS depression/anxiety subscales, post-traumatic symptoms, HRQoL and user satisfaction at 3 months after the intervention.\n\nThis protocol describes a pilot trial to assess feasibility and preliminary effects of a structured psycho-therapeutic intervention to ameliorate mental health in a population severely affected by COVID-19, where evidence for structured psycho-therapy is lacking.", "doi": "10.3389/fpsyt.2022.907215", "pmid": "35911237", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9334556"}], "notes": [], "created": "2022-08-11T12:04:49.893Z", "modified": "2022-08-11T12:04:49.909Z"}, {"entity": "publication", "iuid": "492bb62d87bc4d089a0e222326142c51", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/492bb62d87bc4d089a0e222326142c51.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/492bb62d87bc4d089a0e222326142c51"}}, "title": "Changes in food-related costs during the COVID-19 pandemic among families managing food allergy.", "authors": [{"family": "Golding", "given": "Michael A", "initials": "MA"}, {"family": "Lemoine-Courcelles", "given": "Cath\u00e9rine", "initials": "C"}, {"family": "Abrams", "given": "Elissa M", "initials": "EM"}, {"family": "Ben-Shoshan", "given": "Moshe", "initials": "M"}, {"family": "B\u00e9gin", "given": "Philippe", "initials": "P"}, {"family": "Chan", "given": "Edmond S", "initials": "ES"}, {"family": "Chu", "given": "Derek K", "initials": "DK"}, {"family": "Gerdts", "given": "Jennifer D", "initials": "JD"}, {"family": "Povolo", "given": "Beatrice", "initials": "B"}, {"family": "Kim", "given": "Harold", "initials": "H"}, {"family": "Simons", "given": "Elinor", "initials": "E"}, {"family": "Upton", "given": "Julia", "initials": "J"}, {"family": "Protudjer", "given": "Jennifer L P", "initials": "JLP"}], "type": "journal article", "published": "2022-07-15", "journal": {"title": "Front Allergy", "issn": "2673-6101", "volume": "3", "pages": "915014", "issn-l": null}, "abstract": "The COVID-19 pandemic has affected the supply, cost, and demand for certain foods, but it is not clear how these changes have affected food-allergic households.\n\nTo describe the changes in food-related costs that have followed COVID-19, as reported by higher- and lower-income households with a food-allergic member.\n\nBetween May 1-June 30, 2020, Canadian households, with at least one food-allergic member, completed an online survey on food shopping and preparation habits before and during the COVID-19 pandemic. The sample was divided into binary groups, either higher or lower than the sample median income. Data were analyzed using descriptive statistics and multiple regression.\n\nThe sample was comprised of 102 participants (i.e., 51/ income group). The three most common food allergies amongst both groups were peanuts, tree nuts and milk. Since the start of the pandemic, both groups reported greater monthly direct grocery costs, although costs amongst the higher-income group were twice as high as the lower-income group ($212.86 vs. $98.89, respectively). Indirect food preparation costs were similarly elevated. Higher-income households with food procurement difficulties reported increased indirect shopping costs following the outbreak of COVID-19, whereas those without such difficulties reported decreased costs. Lower-income households with allergies to milk, wheat, or eggs (i.e., staple allergy) experienced a larger change in indirect food preparation costs following the outbreak of COVID-19 relative to those with other food allergies ($244.58 vs. -$20.28, respectively; p = 0.03).\n\nBoth higher and lower income households with food allergy reported greater direct food costs and indirect food preparation costs following the COVID-19. Households with staple allergy and those with difficulties finding their typical food items were particularly affected.", "doi": "10.3389/falgy.2022.915014", "pmid": "35910861", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9334569"}], "notes": [], "created": "2022-08-11T12:05:21.065Z", "modified": "2022-08-11T12:05:21.099Z"}, {"entity": "publication", "iuid": "c7807ad156c64452a058896d3a6ab36b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7807ad156c64452a058896d3a6ab36b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7807ad156c64452a058896d3a6ab36b"}}, "title": "Protective effects of statins on COVID-19 risk, severity and fatal outcome: a nationwide Swedish cohort study.", "authors": [{"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Franz\u00e9n", "given": "Stefan", "initials": "S"}, {"family": "N\u00e5tman", "given": "Jonatan", "initials": "J"}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Parmryd", "given": "Ingela", "initials": "I"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2022-07-14", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "12047", "issn-l": "2045-2322"}, "abstract": "The impact of statins on COVID-19 remains unclear. This study aims to investigate whether statin exposure assessed both in the population and in well-defined cohorts of COVID-19 patients may affect the risk and severity of COVID-19 using nationwide Swedish population-based register data. A population \u2265 40 years was selected by age/sex-stratified random sampling from the Swedish population on 1 Jan 2020. COVID-19 outcomes were identified from the SmiNet database, the National Patient Register and/or Cause-of-Death Register and linked with the National Prescribed Drug Register and sociodemographic registers. Statin exposure was defined as any statin prescriptions in the year before index date. In Cox regressions, confounding was addressed using propensity score ATT (Average Treatment effect in the Treated) weighting. Of 572,695 individuals in the overall cohort, 22.3% had prior statin treatment. After ATT weighting, protective effects were observed among statin user for hospitalization and COVID-19 death in the overall cohort and onset cohort. In the hospitalized cohort, statin use was only associated with lower risk for death (HR = 0.86, 95% CI 0.79-0.95), but not ICU admission. Statin-treated individuals appear to have lower COVID-19 mortality than nonusers, whether assessed in the general population, from COVID-19 onset or from hospitalization.", "doi": "10.1038/s41598-022-16357-2", "pmid": "35835835", "labels": {"Topics: Register-based research": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-16357-2"}, {"db": "pmc", "key": "PMC9282150"}], "notes": [], "created": "2022-08-12T09:01:17.228Z", "modified": "2022-08-12T09:02:19.709Z"}, {"entity": "publication", "iuid": "f6f8942eecdf4d63ad6c37b4691d8742", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6f8942eecdf4d63ad6c37b4691d8742.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6f8942eecdf4d63ad6c37b4691d8742"}}, "title": "Work-Life Enrichment and Interference Among Swedish Workers: Trends From 2016 Until the COVID-19 Pandemic.", "authors": [{"family": "Brulin", "given": "Emma", "initials": "E"}, {"family": "Leineweber", "given": "Constanze", "initials": "C"}, {"family": "Peristera", "given": "Paraskevi", "initials": "P"}], "type": "journal article", "published": "2022-07-13", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "13", "pages": "854119", "issn-l": "1664-1078"}, "abstract": "The COVID-19 pandemic has altered workers' possibilities to combine work and private life. Work and private life could either interfere with each other, that is, when conflicting demands arise, or enrich, that is, when the two roles are beneficial to one another. Analyzing data from the Swedish Longitudinal Occupational Survey of Health through individual growth models, we investigated time trends of interference and enrichment between work and private life from 2016 through March to September 2020, which is during the first wave of the pandemic. The sample included workers who had remained in the same workplace throughout the study period and worked at least 30% of full time, reaching 5,465 individuals. In addition, we examined trends in level of interference and enrichment across gender and industries. Results showed that Life-to-work interference increased over time in the Swedish working population, but neither did work-to-life interference nor enrichment. We observed only marginal differences across gender. Also, in the industries of fine manufacturing and real-estate activities, a decrease in interference, work-to-life interference, and life-to-work interference, respectively, was observed. In the human health and social care industry, an increase in interference and life-to-work interference was seen. Our conclusion is that overall changes to the possibilities to balance work and private life have occurred for workers in Sweden during the first period of the pandemic. Further studies are needed to study development time trends throughout the pandemic and across different occupations.", "doi": "10.3389/fpsyg.2022.854119", "pmid": "35910960", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9328076"}], "notes": [], "created": "2022-08-11T12:05:05.016Z", "modified": "2022-08-11T12:05:05.022Z"}, {"entity": "publication", "iuid": "b396337b473149e2918bc8cd12aeffaf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b396337b473149e2918bc8cd12aeffaf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b396337b473149e2918bc8cd12aeffaf"}}, "title": "Effectiveness of a fourth dose of mRNA COVID-19 vaccine against all-cause mortality in long-term care facility residents and in the oldest old: A nationwide, retrospective cohort study in Sweden.", "authors": [{"family": "Nordstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Ballin", "given": "Marcel", "initials": "M"}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-07-13", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "pages": "100466", "issn-l": null}, "abstract": "The effect of a fourth dose of COVID-19 vaccine on the risk of death in the oldest and frailest individuals is unknown.\n\nTwo matched cohorts were formed using Swedish nationwide registers. In the first, residents of long-term care facilities (LTCFs) given a fourth dose of an mRNA vaccine from 1 January 2022 onwards were matched 1:1 on birth year and county of residence to residents given at least a third dose (N = 24,524). In the second, all individuals aged \u226580 years given a fourth dose were matched 1:1 to individuals given at least a third dose (N = 394,104). Cox regression models were used to estimate hazard ratios for all-cause mortality in fourth-dose recipients as compared with in third-dose recipients, with relative vaccine effectiveness (VE) estimated as 1 minus the hazard ratio.\n\nFrom 7 days after baseline and onwards, there were 1119 deaths in the LTCF cohort during a median follow-up of 77 days and a maximum follow-up of 126 days. During days 7 to 60, the VE of the fourth dose was 39% (95% CI, 29-48), which declined to 27% (95% CI, -2-48) during days 61 to 126. In the cohort of all individuals aged \u226580 years, there were 5753 deaths during a median follow-up of 73 days and a maximum follow-up of 143 days. During days 7 to 60, the VE of the fourth dose was 71% (95% CI, 69-72), which declined to 54% (95% CI, 48-60) during days 61 to 143. The VE of the fourth dose seemed stronger when it was compared to third-dose recipients where at least four months had passed since vaccination (P < 0\u00b7001 for interaction).\n\nAs compared with a third dose, a fourth dose of an mRNA COVID-19 vaccine, administered during the Omicron era, was associated with reduced risk of death from all causes in residents of LTCFs and in the oldest old during the first two months, after which the protection became slightly lower. These findings suggest that a fourth dose may prevent premature mortality in the oldest and frailest even after the emergence of the Omicron variant, although the timing of vaccination seems to be important with respect to the slight waning observed after two months.\n\nThere was no funding source for this study.", "doi": "10.1016/j.lanepe.2022.100466", "pmid": "35855494", "labels": {"Topics: Register-based research": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(22)00162-4"}, {"db": "pmc", "key": "PMC9277096"}], "notes": [], "created": "2022-08-12T08:48:27.521Z", "modified": "2022-08-12T08:48:27.527Z"}, {"entity": "publication", "iuid": "731c3b854fdd4693bbf5054df50f6f20", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/731c3b854fdd4693bbf5054df50f6f20.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/731c3b854fdd4693bbf5054df50f6f20"}}, "title": "Community-based response to the COVID-19 pandemic: case study of a home isolation centre using flexible surge capacity.", "authors": [{"family": "Phattharapornjaroen", "given": "P", "initials": "P"}, {"family": "Carlstr\u00f6m", "given": "E", "initials": "E"}, {"family": "Sivarak", "given": "O", "initials": "O"}, {"family": "Tansuwannarat", "given": "P", "initials": "P"}, {"family": "Chalermdamrichai", "given": "P", "initials": "P"}, {"family": "Sittichanbuncha", "given": "Y", "initials": "Y"}, {"family": "Kongtoranin", "given": "L", "initials": "L"}, {"family": "Phattranonuthai", "given": "R", "initials": "R"}, {"family": "Marlow", "given": "P", "initials": "P"}, {"family": "Winyuchonjaroen", "given": "W", "initials": "W"}, {"family": "Pongpasupa", "given": "N", "initials": "N"}, {"family": "Khorram-Manesh", "given": "A", "initials": "A"}], "type": "journal article", "published": "2022-07-13", "journal": {"title": "Public Health", "issn": "1476-5616", "volume": "211", "pages": "29-36", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) has consumed many available resources within contingency plans, necessitating new capacity surges and novel approaches. This study aimed to explore the possibility of implementing the concept of flexible surge capacity to reduce the burden on hospitals by focussing on community resources to develop home isolation centres in Bangkok, Thailand.\n\nA qualitative study consisted of observational and semi-structured interview data.\n\nThe development and activities of home isolation centres were observed, and interviews were conducted with leaders and operational workforces. Data were deductively analysed and categorised based on the practical elements necessary in disaster and emergency management.\n\nData were categorised into the seven collaborative elements of the major incident medical management and support model. The command-and-control category demonstrated four subcategories: (1) coordination and collaboration; (2) staff engagement; (3) responsibility clarification; and (4) sustainability. Safety presented two subcategories: (1) patients' information privacy and treatment; and (2) personnel safety and privacy. Communication showed internal and external communications subcategories. Assessment, triage, treatment and transport followed the processes of the COVID-19 treatment protocols according to the World Health Organisation (WHO) guidelines and hospital operations. Several supply- and patient-related challenges were identified and managed during centre development.\n\nThe use of community resources, based on the flexible surge capacity concept, is feasible under restricted circumstances and reduced the burden on hospitals during the COVID-19 pandemic. Continuous education among multidisciplinary volunteer teams facilitated their full participation and engagement. The concept of flexible surge capacity may promote an alternative community-based care opportunity, irrespective of emergencies' aetiology.", "doi": "10.1016/j.puhe.2022.06.025", "pmid": "35994836", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0033-3506(22)00182-2"}, {"db": "pmc", "key": "PMC9276643"}], "notes": [], "created": "2022-09-12T19:00:44.873Z", "modified": "2022-09-12T19:00:56.112Z"}, {"entity": "publication", "iuid": "9e30c2527eb24c79b180aa68c68b2d26", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9e30c2527eb24c79b180aa68c68b2d26.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9e30c2527eb24c79b180aa68c68b2d26"}}, "title": "mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells.", "authors": [{"family": "Bevers", "given": "Sanne", "initials": "S"}, {"family": "Kooijmans", "given": "Sander A A", "initials": "SAA"}, {"family": "Van de Velde", "given": "Elien", "initials": "E"}, {"family": "Evers", "given": "Martijn J W", "initials": "MJW"}, {"family": "Seghers", "given": "Sofie", "initials": "S"}, {"family": "Gitz-Francois", "given": "Jerney J J M", "initials": "JJJM"}, {"family": "van Kronenburg", "given": "Nicky C H", "initials": "NCH"}, {"family": "Fens", "given": "Marcel H A M", "initials": "MHAM"}, {"family": "Mastrobattista", "given": "Enrico", "initials": "E"}, {"family": "Hassler", "given": "Lucie", "initials": "L"}, {"family": "Sork", "given": "Helena", "initials": "H"}, {"family": "Lehto", "given": "Taavi", "initials": "T"}, {"family": "Ahmed", "given": "Kariem E", "initials": "KE"}, {"family": "El Andaloussi", "given": "Samir", "initials": "S"}, {"family": "Fiedler", "given": "Katja", "initials": "K"}, {"family": "Breckpot", "given": "Karine", "initials": "K"}, {"family": "Maes", "given": "Michael", "initials": "M"}, {"family": "Van Hoorick", "given": "Diane", "initials": "D"}, {"family": "Bastogne", "given": "Thierry", "initials": "T"}, {"family": "Schiffelers", "given": "Raymond M", "initials": "RM"}, {"family": "De Koker", "given": "Stefaan", "initials": "S"}], "type": "journal article", "published": "2022-07-12", "journal": {"title": "Mol Ther", "issn": "1525-0024", "issn-l": null}, "abstract": "mRNA vaccines have recently proved to be highly effective against SARS-CoV-2. Key to their success is the lipid-based nanoparticle (LNP), which enables efficient mRNA expression and endows the vaccine with adjuvant properties that drive potent antibody responses. Effective cancer vaccines require long-lived, qualitative CD8 T cell responses instead of antibody responses. Systemic vaccination appears to be the most effective route, but necessitates adaptation of LNP composition to deliver mRNA to antigen-presenting cells. Using a design-of-experiments methodology, we tailored mRNA-LNP compositions to achieve high-magnitude tumor-specific CD8 T cell responses within a single round of optimization. Optimized LNP compositions resulted in enhanced mRNA uptake by multiple splenic immune cell populations. Type I interferon and phagocytes were found to be essential for the T cell response. Surprisingly, we also discovered a yet unidentified role of B cells in stimulating the vaccine-elicited CD8 T cell response. Optimized LNPs displayed a similar, spleen-centered biodistribution profile in non-human primates and did not trigger histopathological changes in liver and spleen, warranting their further assessment in clinical studies. Taken together, our study clarifies the relationship between nanoparticle composition and their T cell stimulatory capacity and provides novel insights into the underlying mechanisms of effective mRNA-LNP-based antitumor immunotherapy.", "doi": "10.1016/j.ymthe.2022.07.007", "pmid": "35821637", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S1525-0016(22)00428-2"}, {"db": "pmc", "key": "PMC9273295"}], "notes": [], "created": "2022-08-17T10:36:40.221Z", "modified": "2022-08-17T10:36:52.133Z"}, {"entity": "publication", "iuid": "c1c8534aa33042ff8fe7fa5a16399331", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1c8534aa33042ff8fe7fa5a16399331.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1c8534aa33042ff8fe7fa5a16399331"}}, "title": "Working conditions for hospital-based maternity and neonatal health care workers during extraordinary situations - A pre-/post COVID-19 pandemic analysis and lessons learned.", "authors": [{"family": "Akerstrom", "given": "Magnus", "initials": "M"}, {"family": "Carlsson", "given": "Ylva", "initials": "Y"}, {"family": "Sengpiel", "given": "Verena", "initials": "V"}, {"family": "Veje", "given": "Malin", "initials": "M"}, {"family": "Elfvin", "given": "Anders", "initials": "A"}, {"family": "Jonsdottir", "given": "Ingibj\u00f6rg H", "initials": "IH"}, {"family": "Degl'Innocenti", "given": "Alessio", "initials": "A"}, {"family": "Ahlstrom", "given": "Linda", "initials": "L"}, {"family": "Wijk", "given": "Helle", "initials": "H"}, {"family": "Linden", "given": "Karolina", "initials": "K"}], "type": "journal article", "published": "2022-07-12", "journal": {"title": "Sex Reprod Healthc", "issn": "1877-5764", "volume": "33", "pages": "100755", "issn-l": null}, "abstract": "The aim of this study was to investigate how the changed work routines during the COVID-19 pandemic has been affecting the working environment for hospital-based maternity and neonatal health care workers, and to identify preventive measures to be used in future situations when health care organizations are under pressure.\n\nAll maternity and neonatal health care workers in a Swedish university hospital were surveyed during October 2019 and September 2020. The data was analyzed by document analysis of implemented changes in working routines, a quantitative analysis of the overall effects on the working conditions, and a qualitative analysis of open-ended responses.\n\nA total of 660 maternity and neonatal health care workers completed the pre-COVID-19 survey (74% response rate) and 382 the COVID-19 survey (35% response rate). Lack of personal protective equipment, worry about becoming infected, uncertainty whether implemented changes were enough, and challenges in communicating updated routines had negative effects on maternity and neonatal health care workers' working conditions. Team spirit and feeling valued by peers had a positive effect.\n\nResults suggest that negative effects on maternity and neonatal health care workers' health can partly be prevented in future critical situations by creating a work climate that acknowledges the employees' worry about being infected, securing adequate pre-conditions for managers, creating a strong psychosocial safety climate and systematically improving the working conditions for the maternity and neonatal health care workers, as well as maintaining the positive perceived effects of increased team spirit and feeling valued by peers.", "doi": "10.1016/j.srhc.2022.100755", "pmid": "35853385", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1877-5756(22)00061-1"}, {"db": "pmc", "key": "PMC9273518"}], "notes": [], "created": "2022-08-12T08:50:16.161Z", "modified": "2022-08-12T08:50:16.166Z"}, {"entity": "publication", "iuid": "77d56ca741194f1b8a8d8f00738a6877", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/77d56ca741194f1b8a8d8f00738a6877.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/77d56ca741194f1b8a8d8f00738a6877"}}, "title": "School Nurses' Perceptions About Student's Wellbeing During the Covid-19 Pandemic in Sweden.", "authors": [{"family": "Martinsson", "given": "Eva", "initials": "E"}, {"family": "Garmy", "given": "Pernilla", "initials": "P", "orcid": "0000-0003-1643-0171", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc4733a9e87a42fea6e7a7323feb61b3.json"}}, {"family": "Einberg", "given": "Eva-Lena", "initials": "EL", "orcid": "0000-0002-5586-3810", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d67e636861d492fb682ec1601422cd0.json"}}], "type": "journal article", "published": "2022-07-12", "journal": {"title": "J Sch Nurs", "issn": "1546-8364", "pages": "10598405221112443", "issn-l": null}, "abstract": "The coronavirus 2019 (Covid-19) pandemic has affected both the private and public lives of people worldwide. Countries have chosen different strategies to reduce the spread of infection, including school closures and distance learning. This study aimed to describe school nurses' perceptions about the wellbeing of students during the Covid-19 pandemic in Sweden. Interviews in five focus groups and one individual were conducted with 17 school nurses in Sweden. The interviews were analyzed using a qualitative content analysis. According to the school nurses' perceptions, students were concerned about spreading infection, becoming infected themselves, their academic performances, and longing for socialization. The change in the school situation involved a slower pace and less anxiety for some students, more or less physical activity, and an increase in screen time.", "doi": "10.1177/10598405221112443", "pmid": "35822231", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9280116"}], "notes": [], "created": "2022-08-17T10:36:15.715Z", "modified": "2022-08-17T10:36:15.752Z"}, {"entity": "publication", "iuid": "ccdb507805c448e09e20070e7245ba29", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ccdb507805c448e09e20070e7245ba29.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ccdb507805c448e09e20070e7245ba29"}}, "title": "Prevalence of fatigue at one-year follow-up from the Gothenburg recovery and rehabilitation after COVID-19 and intensive care unit study.", "authors": [{"family": "Hussain", "given": "Netha", "initials": "N"}, {"family": "Samuelsson", "given": "Carina M", "initials": "CM"}, {"family": "Drummond", "given": "Avril", "initials": "A"}, {"family": "Persson", "given": "Carina U", "initials": "CU"}], "type": "journal article", "published": "2022-07-12", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "11501", "issn-l": "2045-2322"}, "abstract": "Fatigue was a commonly reported sequala after COVID-19. However, there is little literature about the prevalence and predictors of fatigue one year after Intensive Care Unit (ICU) admission following COVID-19. Therefore, the aim of this study was to determine the prevalence of fatigue and to identify the predictors prior to, and during the care period in ICU that were associated with fatigue at one year after ICU admission following COVID-19. The dependent variable, fatigue, was assessed using the Swedish version of Fatigue Assessment Scale (S-FAS), in a cohort of 105 individuals cared for at the ICU at the Sahlgrenska University hospital, Sweden during the first wave of the pandemic. The independent variables were related to demographic factors, comorbidities and complications during ICU admission following COVID-19. Fatigue was reported by 64.4% (n = 67) of the individuals. Age (odds ratio: 0.95, confidence interval: 0.92-0.99) and length of stay in the ICU (odds ratio: 1.04, confidence interval: 1.00-1.07) were statistically significant predictors of fatigue one year after ICU admission following COVID-19. The findings from this study will be important for healthcare practitioners, policy makers and the general public in planning the rehabilitation of individuals who underwent ICU care for COVID-19.", "doi": "10.1038/s41598-022-14787-6", "pmid": "35821226", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-14787-6"}, {"db": "pmc", "key": "PMC9276681"}], "notes": [], "created": "2022-08-17T10:37:13.798Z", "modified": "2022-08-17T10:37:13.811Z"}, {"entity": "publication", "iuid": "0fd3e4f3d2f8406f88be2ebd9ec8eef9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0fd3e4f3d2f8406f88be2ebd9ec8eef9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0fd3e4f3d2f8406f88be2ebd9ec8eef9"}}, "title": "Directly immersible silicon photonic probes: Application to rapid SARS-CoV-2 serological testing.", "authors": [{"family": "Angelopoulou", "given": "Michailia", "initials": "M"}, {"family": "Makarona", "given": "Eleni", "initials": "E"}, {"family": "Salapatas", "given": "Alexandros", "initials": "A"}, {"family": "Misiakos", "given": "Konstantinos", "initials": "K"}, {"family": "Synolaki", "given": "Evgenia", "initials": "E"}, {"family": "Ioannidis", "given": "Anastasios", "initials": "A"}, {"family": "Chatzipanagiotou", "given": "Stylianos", "initials": "S"}, {"family": "Ritvos", "given": "Mikael A", "initials": "MA"}, {"family": "Pasternack", "given": "Arja", "initials": "A"}, {"family": "Ritvos", "given": "Olli", "initials": "O"}, {"family": "Petrou", "given": "Panagiota S", "initials": "PS"}, {"family": "Kakabakos", "given": "Sotirios E", "initials": "SE"}], "type": "journal article", "published": "2022-07-12", "journal": {"title": "Biosens Bioelectron", "issn": "1873-4235", "volume": "215", "pages": "114570", "issn-l": null}, "abstract": "Silicon photonic probes based on broad-band Mach-Zehnder interferometry are explored for the first time as directly immersible immunosensors alleviating the need for microfluidics and pumps. Each probe includes two U-shaped waveguides allowing light in- and out-coupling from the same chip side through a bifurcated fiber and a mechanical coupler. At the opposite chip side, two Mach-Zehnder interferometers (MZI) are located enabling real-time monitoring of binding reactions by immersion of this chip side into a sample. The sensing arm windows of the two MZIs have different length resulting in two distinct peaks in the Fourier domain, the phase shift of which can be monitored independently through Fast Fourier Transform of the output spectrum. The photonic probes analytical potential was demonstrated through detection of antibodies against SARS-CoV-2 in human serum samples. For this, one MZI was functionalized with the Receptor Binding Domain (RBD) of SARS-CoV-2 Spike 1 protein, and the other with bovine serum albumin to serve as reference. The biofunctionalized probes were immersed for 10 min in human serum sample and then for 5 min in goat anti-human IgG Fc specific antibody solution. Using a humanized rat antibody against SARS-CoV-2 RBD, a detection limit of 20 ng/mL was determined. Analysis of human serum samples indicated that the proposed sensor discriminated completely non-infected/non-vaccinated from vaccinated individuals, and the antibodies levels determined correlated well with those determined in the same samples by ELISA. These results demonstrated the potential of the proposed sensor to serve as an efficient tool for expeditious point-of-care testing.", "doi": "10.1016/j.bios.2022.114570", "pmid": "35850040", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0956-5663(22)00610-8"}, {"db": "pmc", "key": "PMC9273522"}], "notes": [], "created": "2022-08-12T08:51:43.044Z", "modified": "2022-08-12T08:51:43.074Z"}, {"entity": "publication", "iuid": "dec4fedc676d4600898cf479f3c3f403", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dec4fedc676d4600898cf479f3c3f403.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dec4fedc676d4600898cf479f3c3f403"}}, "title": "Clinical prediction models for mortality in patients with covid-19: external validation and individual participant data meta-analysis.", "authors": [{"family": "de Jong", "given": "Valentijn M T", "initials": "VMT", "orcid": "0000-0001-9921-3468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5147390937d4bdbb706fd24820bdabc.json"}}, {"family": "Rousset", "given": "Rebecca Z", "initials": "RZ", "orcid": "0000-0001-9355-7286", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/657ff3d472c94b598267473a115a9a24.json"}}, {"family": "Antonio-Villa", "given": "Neftal\u00ed Eduardo", "initials": "NE", "orcid": "0000-0002-6879-1078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2f6ed0f02a24c9db9ec0a0f2a138302.json"}}, {"family": "Buenen", "given": "Arnoldus G", "initials": "AG", "orcid": "0000-0002-0948-1379", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c3427d44e1d840729a381a2a95fd13c2.json"}}, {"family": "Van Calster", "given": "Ben", "initials": "B", "orcid": "0000-0003-1613-7450", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47c7125c051c47b58e7a6462f2ddc79b.json"}}, {"family": "Bello-Chavolla", "given": "Omar Yaxmehen", "initials": "OY", "orcid": "0000-0003-3093-937X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/17af31a1a5914f5bbfa87a312ffdc995.json"}}, {"family": "Brunskill", "given": "Nigel J", "initials": "NJ"}, {"family": "Curcin", "given": "Vasa", "initials": "V", "orcid": "0000-0002-8308-2886", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91c85856301d422b8071753e1d36fd31.json"}}, {"family": "Damen", "given": "Johanna A A", "initials": "JAA", "orcid": "0000-0001-7401-4593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b6107f804af47a3a2b27ceeb6ade6ca.json"}}, {"family": "Ferm\u00edn-Mart\u00ednez", "given": "Carlos A", "initials": "CA", "orcid": "0000-0001-5627-8851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10fdb216049244a6a7d87788674e9a4e.json"}}, {"family": "Fern\u00e1ndez-Chirino", "given": "Luisa", "initials": "L", "orcid": "0000-0002-8326-1219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c06b680084d548d88e4b29e70ed06be4.json"}}, {"family": "Ferrari", "given": "Davide", "initials": "D", "orcid": "0000-0003-2365-4157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/419cc33149304e7ab894b00491377ffd.json"}}, {"family": "Free", "given": "Robert C", "initials": "RC"}, {"family": "Gupta", "given": "Rishi K", "initials": "RK", "orcid": "0000-0002-6257-1285", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/199d63fa58c84f44ba02d388cf89bdb7.json"}}, {"family": "Haldar", "given": "Pranabashis", "initials": "P"}, {"family": "Hedberg", "given": "Pontus", "initials": "P", "orcid": "0000-0003-3153-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd6af5accfc84ff9a81983a5ab6683aa.json"}}, {"family": "Korang", "given": "Steven Kwasi", "initials": "SK", "orcid": "0000-0002-6521-0928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a3fa688bba644138b31d213fefeb31e.json"}}, {"family": "Kurstjens", "given": "Steef", "initials": "S"}, {"family": "Kusters", "given": "Ron", "initials": "R"}, {"family": "Major", "given": "Rupert W", "initials": "RW", "orcid": "0000-0003-4920-623X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/853c99a3b7b149c8a0b6f28d29013785.json"}}, {"family": "Maxwell", "given": "Lauren", "initials": "L"}, {"family": "Nair", "given": "Rajeshwari", "initials": "R"}, {"family": "Naucler", "given": "Pontus", "initials": "P", "orcid": "0000-0002-8185-2648", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78b415aee4864810b8ce8f1962fa288f.json"}}, {"family": "Nguyen", "given": "Tri-Long", "initials": "TL", "orcid": "0000-0002-6376-7212", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4869454669049bab81bb55809f3a446.json"}}, {"family": "Noursadeghi", "given": "Mahdad", "initials": "M"}, {"family": "Rosa", "given": "Rossana", "initials": "R", "orcid": "0000-0002-3755-7780", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13954374ed884b65b833316c1ce8991d.json"}}, {"family": "Soares", "given": "Felipe", "initials": "F", "orcid": "0000-0002-2837-1853", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7f180e740e4496b867c75535a5ddf2c.json"}}, {"family": "Takada", "given": "Toshihiko", "initials": "T", "orcid": "0000-0002-8032-6224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/285f5b69f2c741c3a6e7b268123c5a97.json"}}, {"family": "van Royen", "given": "Florien S", "initials": "FS", "orcid": "0000-0002-6785-214X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d92466b48a0e43f5aa2e326eff1457d6.json"}}, {"family": "van Smeden", "given": "Maarten", "initials": "M", "orcid": "0000-0002-5529-1541", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8dd2487a416242099bd2dffdc5d05be9.json"}}, {"family": "Wynants", "given": "Laure", "initials": "L", "orcid": "0000-0002-3037-122X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb8e9ef168d444e9b821f22e9a4e06ff.json"}}, {"family": "Modr\u00e1k", "given": "Martin", "initials": "M", "orcid": "0000-0002-8886-7797", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e1aceac9a864506b36dbfddab9608c5.json"}}, {"family": "CovidRetro collaboration", "given": "", "initials": ""}, {"family": "Asselbergs", "given": "Folkert W", "initials": "FW", "orcid": "0000-0002-1692-8669", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/578ce5a865454ff3be1545f940cabbdc.json"}}, {"family": "Linschoten", "given": "Marijke", "initials": "M", "orcid": "0000-0002-4541-080X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7714859c3fc420088a20cf23eda12cb.json"}}, {"family": "CAPACITY-COVID consortium", "given": "", "initials": ""}, {"family": "Moons", "given": "Karel G M", "initials": "KGM"}, {"family": "Debray", "given": "Thomas P A", "initials": "TPA", "orcid": "0000-0002-1790-2719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/343d2f07d494422f91507fd6bca0dcad.json"}}], "type": "journal article", "published": "2022-07-12", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "378", "pages": "e069881", "issn-l": null}, "abstract": "To externally validate various prognostic models and scoring rules for predicting short term mortality in patients admitted to hospital for covid-19.\n\nTwo stage individual participant data meta-analysis.\n\nSecondary and tertiary care.\n\n46 914 patients across 18 countries, admitted to a hospital with polymerase chain reaction confirmed covid-19 from November 2019 to April 2021.\n\nMultiple (clustered) cohorts in Brazil, Belgium, China, Czech Republic, Egypt, France, Iran, Israel, Italy, Mexico, Netherlands, Portugal, Russia, Saudi Arabia, Spain, Sweden, United Kingdom, and United States previously identified by a living systematic review of covid-19 prediction models published in The BMJ, and through PROSPERO, reference checking, and expert knowledge.\n\nPrognostic models identified by the living systematic review and through contacting experts. A priori models were excluded that had a high risk of bias in the participant domain of PROBAST (prediction model study risk of bias assessment tool) or for which the applicability was deemed poor.\n\nEight prognostic models with diverse predictors were identified and validated. A two stage individual participant data meta-analysis was performed of the estimated model concordance (C) statistic, calibration slope, calibration-in-the-large, and observed to expected ratio (O:E) across the included clusters.\n\n30 day mortality or in-hospital mortality.\n\nDatasets included 27 clusters from 18 different countries and contained data on 46 914patients. The pooled estimates ranged from 0.67 to 0.80 (C statistic), 0.22 to 1.22 (calibration slope), and 0.18 to 2.59 (O:E ratio) and were prone to substantial between study heterogeneity. The 4C Mortality Score by Knight et al (pooled C statistic 0.80, 95% confidence interval 0.75 to 0.84, 95% prediction interval 0.72 to 0.86) and clinical model by Wang et al (0.77, 0.73 to 0.80, 0.63 to 0.87) had the highest discriminative ability. On average, 29% fewer deaths were observed than predicted by the 4C Mortality Score (pooled O:E 0.71, 95% confidence interval 0.45 to 1.11, 95% prediction interval 0.21 to 2.39), 35% fewer than predicted by the Wang clinical model (0.65, 0.52 to 0.82, 0.23 to 1.89), and 4% fewer than predicted by Xie et al's model (0.96, 0.59 to 1.55, 0.21 to 4.28).\n\nThe prognostic value of the included models varied greatly between the data sources. Although the Knight 4C Mortality Score and Wang clinical model appeared most promising, recalibration (intercept and slope updates) is needed before implementation in routine care.", "doi": "10.1136/bmj-2021-069881", "pmid": "35820692", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9273913"}], "notes": [], "created": "2022-08-17T10:37:35.184Z", "modified": "2022-08-17T10:37:36.106Z"}, {"entity": "publication", "iuid": "81ad262b687b4469a0d28c40a200cfb4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/81ad262b687b4469a0d28c40a200cfb4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/81ad262b687b4469a0d28c40a200cfb4"}}, "title": "Impact of COVID-19 pandemic on families living with autism: An online survey.", "authors": [{"family": "Isensee", "given": "Corinna", "initials": "C"}, {"family": "Schmid", "given": "Benjamin", "initials": "B"}, {"family": "Marschik", "given": "Peter B", "initials": "PB"}, {"family": "Zhang", "given": "Dajie", "initials": "D"}, {"family": "Poustka", "given": "Luise", "initials": "L"}], "type": "journal article", "published": "2022-07-11", "journal": {"title": "Res Dev Disabil", "issn": "1873-3379", "volume": "129", "pages": "104307", "issn-l": null}, "abstract": "The current SARS-CoV-2 global pandemic presents a great challenge for governments, health care professionals and the general population. Individuals with autism spectrum disorder (ASD) might be especially vulnerable to restrictions imposed by the crisis.\n\nThe objective of the study was to examine the impact of the SARSCoV- 2 pandemic on children with ASD and their families.\n\nWe conducted an online survey two months after the beginning of lock-down (18th of May to 5th of July 2020) in Germany and Austria. We investigated behavioral and emotional changes of children related to the lock-down alongside parental stress and intrafamilial burden OUTCOME AND RESULTS: Of the 216 participating families with an autistic child (mean age: 12.23 years), nearly 50% reported aggravation of autistic symptoms and heightened parental stress. Families reported discontinuation of therapy, more intrafamilial conflicts and increase of psychopharmacological medication of the child.\n\nOur report on short-term detrimental effects of the pandemic calls for thorough investigation of long-term sequalae for children and families.", "doi": "10.1016/j.ridd.2022.104307", "pmid": "35908370", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0891-4222(22)00137-8"}, {"db": "pmc", "key": "PMC9271458"}], "notes": [], "created": "2022-08-12T08:31:03.122Z", "modified": "2022-08-12T08:31:03.149Z"}, {"entity": "publication", "iuid": "f6c3188e1df54926b231706fa4c42a81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6c3188e1df54926b231706fa4c42a81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6c3188e1df54926b231706fa4c42a81"}}, "title": "IMpact of COVID-19 in Patients With Severe Alpha-1 Antitrypsin Deficiency: The IMCA1 Study of the EARCO Clinical Research Collaboration.", "authors": [{"family": "Parr", "given": "David G", "initials": "DG"}, {"family": "Chorostowska-Wynimko", "given": "Joanna", "initials": "J"}, {"family": "Corsico", "given": "Angelo", "initials": "A"}, {"family": "Esquinas", "given": "Cristina", "initials": "C"}, {"family": "McElvaney", "given": "Gerard N", "initials": "GN"}, {"family": "Sark", "given": "Annelot D", "initials": "AD"}, {"family": "Sucena", "given": "Maria", "initials": "M"}, {"family": "Tanash", "given": "Hanan", "initials": "H"}, {"family": "Turner", "given": "Alice M", "initials": "AM"}, {"family": "Miravitlles", "given": "Marc", "initials": "M"}], "type": "case reports", "published": "2022-07-11", "journal": {"title": "Arch Bronconeumol", "issn": "1579-2129", "issn-l": null}, "abstract": null, "doi": "10.1016/j.arbres.2022.07.002", "pmid": "35879122", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0300-2896(22)00488-4"}, {"db": "pmc", "key": "PMC9272568"}], "notes": [], "created": "2022-08-12T08:38:44.333Z", "modified": "2022-08-12T08:38:44.362Z"}, {"entity": "publication", "iuid": "7342214e725c4fedba1cba39059bd007", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7342214e725c4fedba1cba39059bd007.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7342214e725c4fedba1cba39059bd007"}}, "title": "Building Process-Oriented Data Science Solutions for Real-World Healthcare.", "authors": [{"family": "Fernandez-Llatas", "given": "Carlos", "initials": "C", "orcid": "0000-0002-2819-5597", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/571fddd1da9f4a4cab2c5b3a35e1214e.json"}}, {"family": "Martin", "given": "Niels", "initials": "N", "orcid": "0000-0003-3279-3853", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7adc49ffd4c04f5990561757d9b05060.json"}}, {"family": "Johnson", "given": "Owen", "initials": "O"}, {"family": "Sepulveda", "given": "Marcos", "initials": "M", "orcid": "0000-0002-9467-7666", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46fce16f5df54618aabfb09089b1057f.json"}}, {"family": "Helm", "given": "Emmanuel", "initials": "E", "orcid": "0000-0002-1323-3511", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/909fe49fc92243eaab55745571d20610.json"}}, {"family": "Munoz-Gama", "given": "Jorge", "initials": "J", "orcid": "0000-0002-6908-3911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/217b35c6e73f4c5b91e953948735f8c8.json"}}], "type": "editorial", "published": "2022-07-10", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "14", "issn-l": null}, "abstract": "The COVID-19 pandemic has highlighted some of the opportunities, problems and barriers facing the application of Artificial Intelligence to the medical domain. It is becoming increasingly important to determine how Artificial Intelligence will help healthcare providers understand and improve the daily practice of medicine. As a part of the Artificial Intelligence research field, the Process-Oriented Data Science community has been active in the analysis of this situation and in identifying current challenges and available solutions. We have identified a need to integrate the best efforts made by the community to ensure that promised improvements to care processes can be achieved in real healthcare. In this paper, we argue that it is necessary to provide appropriate tools to support medical experts and that frequent, interactive communication between medical experts and data miners is needed to co-create solutions. Process-Oriented Data Science, and specifically concrete techniques such as Process Mining, can offer an easy to manage set of tools for developing understandable and explainable Artificial Intelligence solutions. Process Mining offers tools, methods and a data driven approach that can involve medical experts in the process of co-discovering real-world evidence in an interactive way. It is time for Process-Oriented Data scientists to collaborate more closely with healthcare professionals to provide and build useful, understandable solutions that answer practical questions in daily practice. With a shared vision, we should be better prepared to meet the complex challenges that will shape the future of healthcare.", "doi": "10.3390/ijerph19148427", "pmid": "35886279", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "ijerph19148427"}, {"db": "pmc", "key": "PMC9318799"}], "notes": [], "created": "2022-08-12T08:35:57.278Z", "modified": "2022-08-12T08:35:57.470Z"}, {"entity": "publication", "iuid": "94bf1b1dc8d44a16aecfb754f15419aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/94bf1b1dc8d44a16aecfb754f15419aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/94bf1b1dc8d44a16aecfb754f15419aa"}}, "title": "Epilepsy diagnosis after Covid-19: A population-wide study.", "authors": [{"family": "Westman", "given": "Gabriel", "initials": "G"}, {"family": "Zelano", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2022-07-09", "journal": {"title": "Seizure", "issn": "1532-2688", "volume": "101", "pages": "11-14", "issn-l": null}, "abstract": "We aimed to investigate whether SARS-CoV-2 infection was associated with an increased risk of incident epilepsy.\n\nNational register-based matched study. Verified cases of SARS-CoV-2 infection were acquired from the system for communicable disease surveillance in Sweden (SmiNet) and linked to data from the National Patient Register (NPR) and Cause of Death register in Sweden. Cases and non-infected controls were compared using a Cox proportional hazards model.\n\nA total of 1,221,801 SARS-CoV-2 infected patients and 1,223,312 controls were included. Infection was not associated with an increased risk of epilepsy on a whole population level (HR 1.01, 95% CI 0.92-1.12). Statistically significant effects were observed in patients between 61 and 80 years (HR 1.66, 95% CI 1.37-2.02), also when adjusting for stroke, traumatic brain injury, tumours (same age group HR 1.50, 95% CI 1.24-1.82) and mechanical ventilation (HR 1.28, 95% CI 1.05-1.57). In patients 81-100 years, a similar significant difference was observed (HR 1.77, 95% CI 1.30-2.42), which remained after adjustment for stroke, traumatic brain injury and tumours (HR 1.51, 95% CI 1.10-2.05) but not when mechanical ventilation was included as a covariate (HR 1.34, 95% CI 0.97-1.84).\n\nOn a whole population level, SARS-CoV-2 infections is not associated with an increased risk of epilepsy. In patients above 60 years, a moderately increased risk of epilepsy was observed. However, considering potential non-controllable bias and that Covid-19 patients in intensive care present with a lower risk than the general ICU population, the virus-induced epileptogenic effect is likely very small.", "doi": "10.1016/j.seizure.2022.07.005", "pmid": "35842976", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1059-1311(22)00158-3"}, {"db": "pmc", "key": "PMC9270960"}], "notes": [], "created": "2022-08-12T08:54:07.719Z", "modified": "2022-08-12T08:54:48.844Z"}, {"entity": "publication", "iuid": "f6c12008f39a4cfaa851666b5c3309d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6c12008f39a4cfaa851666b5c3309d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6c12008f39a4cfaa851666b5c3309d4"}}, "title": "Differences between Omicron SARS-CoV-2 RBD and other variants in their ability to interact with cell receptors and monoclonal antibodies.", "authors": [{"family": "Giron", "given": "Carolina Corr\u00eaa", "initials": "CC"}, {"family": "Laaksonen", "given": "Aatto", "initials": "A"}, {"family": "Barroso da Silva", "given": "Fernando Lu\u00eds", "initials": "FL"}], "type": "journal article", "published": "2022-07-09", "journal": {"title": "J Biomol Struct Dyn", "issn": "1538-0254", "pages": "1-21", "issn-l": null}, "abstract": "SARS-CoV-2 remains a health threat with the continuous emergence of new variants. This work aims to expand the knowledge about the SARS-CoV-2 receptor-binding domain (RBD) interactions with cell receptors and monoclonal antibodies (mAbs). By using constant-pH Monte Carlo simulations, the free energy of interactions between the RBD from different variants and several partners (Angiotensin-Converting Enzyme-2 (ACE2) polymorphisms and various mAbs) were predicted. Computed RBD-ACE2-binding affinities were higher for two ACE2 polymorphisms (rs142984500 and rs4646116) typically found in Europeans which indicates a genetic susceptibility. This is amplified for Omicron (BA.1) and its sublineages BA.2 and BA.3. The antibody landscape was computationally investigated with the largest set of mAbs so far in the literature. From the 32 studied binders, groups of mAbs were identified from weak to strong binding affinities (e.g. S2K146). These mAbs with strong binding capacity and especially their combination are amenable to experimentation and clinical trials because of their high predicted binding affinities and possible neutralization potential for current known virus mutations and a universal coronavirus.Communicated by Ramaswamy H. Sarma.", "doi": "10.1080/07391102.2022.2095305", "pmid": "35815535", "labels": {"Category: Biochemistry": null, "Category: Omicron VoC": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-17T10:38:34.796Z", "modified": "2022-08-17T10:38:34.809Z"}, {"entity": "publication", "iuid": "976ccf16ac4f43fab2c6e9abaa215b17", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/976ccf16ac4f43fab2c6e9abaa215b17.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/976ccf16ac4f43fab2c6e9abaa215b17"}}, "title": "Willingness to Accept the COVID-19 Vaccine and Related Factors among Indian Adults: A Cross-Sectional Study.", "authors": [{"family": "Parthasarathi", "given": "Ashwaghosha", "initials": "A", "orcid": "0000-0002-7270-0247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c0a5e6837a421cbbb0314628ae7f24.json"}}, {"family": "Puvvada", "given": "Rahul Krishna", "initials": "RK", "orcid": "0000-0002-4813-9509", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b593c073cfa497c985cf5f897212910.json"}}, {"family": "Shankar", "given": "Malavika", "initials": "M", "orcid": "0000-0003-0462-3988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2a17e45d5b143728f26ac2d1cb8737c.json"}}, {"family": "Siddaiah", "given": "Jayaraj Biligere", "initials": "JB", "orcid": "0000-0001-6055-4580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c8166020c084a9f8508e74cfa0b2f25.json"}}, {"family": "Ganguly", "given": "Koustav", "initials": "K", "orcid": "0000-0001-8531-8154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58b2e0d7853a4b32920e54042e95061d.json"}}, {"family": "Upadhyay", "given": "Swapna", "initials": "S", "orcid": "0000-0003-4699-4082", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c98621d4161241dd9379dca3fa6e1bf1.json"}}, {"family": "Mahesh", "given": "Padukudru Anand", "initials": "PA", "orcid": "0000-0003-1632-5945", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70c3b10ccc334c4c8195556f07c862d0.json"}}], "type": "journal article", "published": "2022-07-08", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "7", "issn-l": null}, "abstract": "To achieve herd immunity to a disease, a large portion of the population needs to be vaccinated, which is possible only when there is broad acceptance of the vaccine within the community. Thus, policymakers need to understand how the general public will perceive the vaccine. This study focused on the degree of COVID-19 vaccine hesitancy and refusal and explored sociodemographic correlations that influence vaccine hesitancy and refusal. A cross-sectional online survey was conducted among the adult population of India. The survey consisted of basic demographic questions and questions from the Vaccination Attitudes Examination (VAX) Scale. Multinomial logistical regression was used to identify correlates of vaccine hesitancy and refusal. Of the 1582 people in the study, 9% refused to become vaccinated and 30.8% were hesitant. We found that both hesitancy and refusal predictors were nearly identical (lower socioeconomic status, female gender, and older age groups), except for three groups (subjects aged 45-64 years, those with approximate income &lt;10,000 INR/month, and those residing in rural households) that showed slightly higher odds of vaccine hesitancy than refusal. We need to address the underlying sociodemographic determinants and formulate public awareness programs to address specific subgroups that are at higher risk of rejecting the vaccine and convert those who are undecided or hesitant into those willing to accept the vaccine.", "doi": "10.3390/vaccines10071095", "pmid": "35891259", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "vaccines10071095"}, {"db": "pmc", "key": "PMC9317945"}], "notes": [], "created": "2022-08-12T08:35:37.008Z", "modified": "2022-08-12T08:35:37.236Z"}, {"entity": "publication", "iuid": "bd69868678954cacbb04b9ba22d688c8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bd69868678954cacbb04b9ba22d688c8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bd69868678954cacbb04b9ba22d688c8"}}, "title": "Susceptibility to SARS-Cov-2 infection and risk for severe COVID-19 in patients with prostate cancer on androgen deprivation therapy.", "authors": [{"family": "Gedeborg", "given": "Rolf", "initials": "R", "orcid": "0000-0002-8850-7863", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/234ef51ed7854efb8bbadc3ce35bf7d9.json"}}, {"family": "Loeb", "given": "Stacy", "initials": "S"}, {"family": "Styrke", "given": "Johan", "initials": "J"}, {"family": "Kiiski-Berggren", "given": "Ritva", "initials": "R"}, {"family": "Garmo", "given": "Hans", "initials": "H"}, {"family": "Stattin", "given": "P\u00e4r", "initials": "P"}], "type": "journal article", "published": "2022-07-08", "journal": {"title": "Int J Cancer", "issn": "1097-0215", "issn-l": null}, "abstract": "Androgen deprivation therapy (ADT) has been hypothesized to protect against COVID-19, but previous observational studies of men with prostate cancer on ADT have been inconsistent regarding mortality risk from coronavirus disease 2019 (COVID-19). Using data from the Prostate Cancer data Base Sweden (PCBaSe), we identified a cohort of 114 547 men with prevalent prostate cancer on the start of follow-up in February 2020, and followed them until 16 December 2020 to evaluate the association between ADT and time to test positive for COVID-19. Among men testing positive for COVID-19, we used regression analyses to estimate the association between ADT and risk of COVID-19-related hospital admission/death from any cause within 30 days of the positive test. In total, 1695 men with prostate cancer tested positive for COVID-19. In crude analyses, exposure to ADT was associated with a 3-fold increased risk of both testing positive for COVID-19 infection and subsequent hospital admission/death. Adjustment for age, comorbidity and prostate cancer risk category substantially attenuated the associations: HR 1.3 (95% CI: 1.1-1.5) for testing positive for COVID-19, and OR 1.4 (95% CI: 1.0-1.9) for risk of subsequent hospital admission/death. In conclusion, although these results suggest increased risks of a positive COVID-19 test, and COVID-19-related hospital admission/death in men on ADT, these findings are likely explained by confounding by old age, cancer-associated morbidity and other comorbidities being more prevalent in men on ADT, rather than a direct effect of the therapy.", "doi": "10.1002/ijc.34204", "pmid": "35802468", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9349425"}], "notes": [], "created": "2022-08-17T10:44:51.277Z", "modified": "2022-08-17T10:44:51.330Z"}, {"entity": "publication", "iuid": "c631eaa6b4ca46d28bcbdd61e322c012", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c631eaa6b4ca46d28bcbdd61e322c012.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c631eaa6b4ca46d28bcbdd61e322c012"}}, "title": "Multi-omics personalized network analyses highlight progressive disruption of central metabolism associated with COVID-19 severity.", "authors": [{"family": "Ambikan", "given": "Anoop T", "initials": "AT"}, {"family": "Yang", "given": "Hong", "initials": "H"}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Svensson Akusj\u00e4rvi", "given": "Sara", "initials": "S"}, {"family": "Gupta", "given": "Soham", "initials": "S"}, {"family": "Lourda", "given": "Magda", "initials": "M"}, {"family": "Sperk", "given": "Maike", "initials": "M"}, {"family": "Arif", "given": "Muhammad", "initials": "M"}, {"family": "Zhang", "given": "Cheng", "initials": "C"}, {"family": "Nordqvist", "given": "Hampus", "initials": "H"}, {"family": "Ponnan", "given": "Sivasankaran Munusamy", "initials": "SM"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Treutiger", "given": "Carl Johan", "initials": "CJ"}, {"family": "O'Mahony", "given": "Liam", "initials": "L"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A"}, {"family": "Benfeitas", "given": "Rui", "initials": "R"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "journal article", "published": "2022-07-08", "journal": {"title": "Cell Syst", "issn": "2405-4720", "issn-l": null}, "abstract": "The clinical outcome and disease severity in coronavirus disease 2019 (COVID-19) are heterogeneous, and the progression or fatality of the disease cannot be explained by a single factor like age or comorbidities. In this study, we used system-wide network-based system biology analysis using whole blood RNA sequencing, immunophenotyping by flow cytometry, plasma metabolomics, and single-cell-type metabolomics of monocytes to identify the potential determinants of COVID-19 severity at personalized and group levels. Digital cell quantification and immunophenotyping of the mononuclear phagocytes indicated a substantial role in coordinating the immune cells that mediate COVID-19 severity. Stratum-specific and personalized genome-scale metabolic modeling indicated monocarboxylate transporter family genes (e.g., SLC16A6), nucleoside transporter genes (e.g., SLC29A1), and metabolites such as \u03b1-ketoglutarate, succinate, malate, and butyrate could play a crucial role in COVID-19 severity. Metabolic perturbations targeting the central metabolic pathway (TCA cycle) can be an alternate treatment strategy in severe COVID-19.", "doi": "10.1016/j.cels.2022.06.006", "pmid": "35933992", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2405-4712(22)00276-9"}], "notes": [], "created": "2022-08-11T11:54:54.053Z", "modified": "2022-08-11T11:55:16.618Z"}, {"entity": "publication", "iuid": "8d87314fecdf428a9ebfa402ab51f02f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d87314fecdf428a9ebfa402ab51f02f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d87314fecdf428a9ebfa402ab51f02f"}}, "title": "The need for a food allergy educator program for allied healthcare professionals in Canada.", "authors": [{"family": "Protudjer", "given": "Jennifer L P", "initials": "JLP", "orcid": "0000-0002-3888-8688", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e35d8fddae04acbb44382b43acb0147.json"}}, {"family": "Venter", "given": "Carina", "initials": "C"}, {"family": "Groetch", "given": "Marion", "initials": "M"}, {"family": "Frykas", "given": "Tara Lynn Mary", "initials": "TLM"}, {"family": "Lidington", "given": "Jasmin", "initials": "J"}, {"family": "Kim", "given": "Harold", "initials": "H"}], "type": "letter", "published": "2022-07-07", "journal": {"title": "Allergy Asthma Clin Immunol", "issn": "1710-1484", "volume": "18", "issue": "1", "pages": "62", "issn-l": null}, "abstract": "Owing to a collaborative approach to patient care, and a paucity of allergists in Canada, there is a need to develop a food allergy educational program for allied health care professionals in Canada. Such programs already exist in the United States and Britain. Herein, we describe the outcomes of recent conference proceedings to inform the educational needs for such a program. As part of the 76th Annual Meeting of the Canadian Society of Allergy and Clinical Immunology (CSACI), held virtually due to the COVID-19 pandemic, we hosted a virtual workshop on the need for a food allergy educator program for Canadian allied health professionals. This workshop was co-developed with the CSACI and an industry partner, and featured allergy specialist dietitians. Attendance was open to all conference delegates, and to allied health professionals. As part of the registration process, registrants posed diverse food allergy-related questions, ranging from how to use an epinephrine autoinjector, to daily management and, how to cure food allergy. A national food allergy educator program will empower both allergy and non-allergy specialist healthcare professionals to appropriately counsel patients. This virtually-delivered program will begin to close a gap in healthcare access resulting from the geographic size of Canada, as it will enhance allied healthcare providers' confidence to provide evidence-based food allergy care appropriately for those with food allergy.", "doi": "10.1186/s13223-022-00701-2", "pmid": "35799220", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13223-022-00701-2"}, {"db": "pmc", "key": "PMC9261880"}], "notes": [], "created": "2022-08-17T10:45:57.211Z", "modified": "2022-08-17T10:45:57.264Z"}, {"entity": "publication", "iuid": "27960d2d50744d5d9cd3007dfcc0fc84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27960d2d50744d5d9cd3007dfcc0fc84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27960d2d50744d5d9cd3007dfcc0fc84"}}, "title": "Prevalence of and risk factors for depression, anxiety, and stress in non-hospitalized asymptomatic and mild COVID-19 patients in East Java province, Indonesia.", "authors": [{"family": "Lusida", "given": "Michael Austin Pradipta", "initials": "MAP"}, {"family": "Salamah", "given": "Sovia", "initials": "S", "orcid": "0000-0002-4815-8929", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fcc2cebe9fcf490f992ad65e73622fc3.json"}}, {"family": "Jonatan", "given": "Michael", "initials": "M"}, {"family": "Wiyogo", "given": "Illona Okvita", "initials": "IO"}, {"family": "Asyari", "given": "Claudia Herda", "initials": "CH"}, {"family": "Ali", "given": "Nurarifah Destianizar", "initials": "ND"}, {"family": "Asmara", "given": "Jose", "initials": "J"}, {"family": "Wahyuningtyas", "given": "Ria Indah", "initials": "RI"}, {"family": "Triyono", "given": "Erwin Astha", "initials": "EA"}, {"family": "Ratnadewi", "given": "Ni Kadek", "initials": "NK"}, {"family": "Irzaldy", "given": "Abyan", "initials": "A"}, {"family": "Alkaff", "given": "Firas Farisi", "initials": "FF"}], "type": "journal article", "published": "2022-07-07", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "7", "pages": "e0270966", "issn-l": "1932-6203"}, "abstract": "Despite abundant data on mental health during the COVID-19 pandemic, 3 important knowledge gaps continue to exist, i.e., 1) studies from low-/middle income countries (LMICs); 2) studies in the later period of the COVID-19 pandemic; and 3) studies on non-hospitalized asymptomatic and mild COVID-19 patients. To address the knowledge gaps, we assessed the prevalence of and the risk factors for mental health symptoms among non-hospitalized asymptomatic and mild COVID-19 patients in one LMIC (Indonesia) during the later period of the pandemic.\n\nThis cross-sectional study was conducted in September 2020 in East Java province, Indonesia. Study population consisted of non-hospitalized asymptomatic and mild COVID-19 patients who were diagnosed based on reverse transcriptase-polymerase chain reaction results from nasopharyngeal swab. Mental health symptoms were evaluated using the Depression Anxiety Stress Scale-21.\n\nFrom 778 non-hospitalized asymptomatic and mild COVID-19 patients, 608 patients were included in the analysis. Patients' median age was 35 years old and 61.2% were male. Of these, 22 (3.6%) reported symptoms of depression, 87 (14.3%) reported symptoms of anxiety, and 48 (7.9%) reported symptoms of stress. Multivariate logistic regression analysis showed that females were more likely to report symptoms of stress (adjusted odds ratio (aOR) = 1.98, p-value = 0.028); healthcare workers were more likely to report symptoms of depression and anxiety (aOR = 5.57, p-value = 0.002 and aOR = 2.92, p-value = 0.014, respectively); and those with a recent history of self-quarantine were more likely to report symptoms of depression and stress (aOR 5.18, p = 0.004 and aOR = 1.86, p = 0.047, respectively).\n\nThe reported prevalence of mental health symptoms, especially depression, was relatively low among non-hospitalized asymptomatic and mild COVID-19 patients during the later period of the COVID-19 pandemic in East Java province, Indonesia. In addition, several risk factors have been identified.", "doi": "10.1371/journal.pone.0270966", "pmid": "35797394", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-21429"}, {"db": "pmc", "key": "PMC9262201"}], "notes": [], "created": "2022-08-17T10:46:19.639Z", "modified": "2022-08-17T10:46:58.176Z"}, {"entity": "publication", "iuid": "7e9ab7e05e884d09a7c7cc6bf6e16f4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e9ab7e05e884d09a7c7cc6bf6e16f4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e9ab7e05e884d09a7c7cc6bf6e16f4d"}}, "title": "Vaccine Safety Surveillance Using Routinely Collected Healthcare Data-An Empirical Evaluation of Epidemiological Designs.", "authors": [{"family": "Schuemie", "given": "Martijn J", "initials": "MJ"}, {"family": "Arshad", "given": "Faaizah", "initials": "F"}, {"family": "Pratt", "given": "Nicole", "initials": "N"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Lai", "given": "Lana Y H", "initials": "LYH"}, {"family": "Li", "given": "Xintong", "initials": "X"}, {"family": "Fortin", "given": "Stephen", "initials": "S"}, {"family": "Minty", "given": "Evan", "initials": "E"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}], "type": "journal article", "published": "2022-07-06", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "issn-l": "1663-9812", "volume": "13", "issue": null, "pages": "893484"}, "abstract": "Background: Routinely collected healthcare data such as administrative claims and electronic health records (EHR) can complement clinical trials and spontaneous reports to detect previously unknown risks of vaccines, but uncertainty remains about the behavior of alternative epidemiologic designs to detect and declare a true risk early. Methods: Using three claims and one EHR database, we evaluate several variants of the case-control, comparative cohort, historical comparator, and self-controlled designs against historical vaccinations using real negative control outcomes (outcomes with no evidence to suggest that they could be caused by the vaccines) and simulated positive control outcomes. Results: Most methods show large type 1 error, often identifying false positive signals. The cohort method appears either positively or negatively biased, depending on the choice of comparator index date. Empirical calibration using effect-size estimates for negative control outcomes can bring type 1 error closer to nominal, often at the cost of increasing type 2 error. After calibration, the self-controlled case series (SCCS) design most rapidly detects small true effect sizes, while the historical comparator performs well for strong effects. Conclusion: When applying any method for vaccine safety surveillance we recommend considering the potential for systematic error, especially due to confounding, which for many designs appears to be substantial. Adjusting for age and sex alone is likely not sufficient to address differences between vaccinated and unvaccinated, and for the cohort method the choice of index date is important for the comparability of the groups. Analysis of negative control outcomes allows both quantification of the systematic error and, if desired, subsequent empirical calibration to restore type 1 error to its nominal value. In order to detect weaker signals, one may have to accept a higher type 1 error.", "doi": "10.3389/fphar.2022.893484", "pmid": "35873596", "labels": {"Category: Vaccines": null, "Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9299244"}, {"db": "pii", "key": "893484"}], "notes": [], "created": "2023-01-13T09:56:38.927Z", "modified": "2023-01-13T10:02:34.231Z"}, {"entity": "publication", "iuid": "5a2ca13f8c3a4714b322dc44beac84e5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5a2ca13f8c3a4714b322dc44beac84e5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5a2ca13f8c3a4714b322dc44beac84e5"}}, "title": "The COVID-19 Pandemic and Adolescents' Psychological Distress: A Multinational Cross-Sectional Study.", "authors": [{"family": "Nguyen", "given": "Hang T M", "initials": "HTM"}, {"family": "Nguyen", "given": "Hoang V", "initials": "HV"}, {"family": "Zouini", "given": "Btissame", "initials": "B", "orcid": "0000-0002-9692-2397", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8935bc90d78143139467d7cfe522f70a.json"}}, {"family": "Senhaji", "given": "Meftaha", "initials": "M", "orcid": "0000-0002-1604-4038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96559d09177a4a34802d08bad5369ca0.json"}}, {"family": "Bador", "given": "Kourosh", "initials": "K", "orcid": "0000-0001-9163-6837", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a3c65199d6449119963e936c3605aca.json"}}, {"family": "Meszaros", "given": "Zsuzsa Szombathyne", "initials": "ZS", "orcid": "0000-0003-2775-0453", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb8155e02af84f868e4b8e58f8e6d73d.json"}}, {"family": "Stevanovic", "given": "Dejan", "initials": "D", "orcid": "0000-0001-8236-5246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fd2d9e3b1114cf5bd2a89e5ab0dc766.json"}}, {"family": "Kerekes", "given": "N\u00f3ra", "initials": "N", "orcid": "0000-0002-8854-0399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/175ef55a6f3b45909a0a76b55cc0e4b3.json"}}], "type": "journal article", "published": "2022-07-06", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "14", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has continued for more than two years, and the impact of this pandemic on mental health has become one of the most important research topics in psychiatry and psychology. The aim of the present study was to assess psychological distress in adolescents across five countries (Sweden, Morocco, Serbia, Vietnam, and the United States of America) during the COVID-19 pandemic.\n\nUsing nonparametric analyses we examined the impact of COVID-19 on distress, measured by the Brief Symptom Inventory, in a sample of 4670 adolescents.\n\nOur results showed that the association between the COVID-19 impact and psychological distress in adolescents' lives was positive and moderate in Morocco and Serbia, positive and weak in Vietnam and the United States of America, and negative and weak in Sweden. We also found that female adolescents reported higher distress levels than male adolescents.\n\nCOVID-19 impacted adolescents and their psychological distress differently depending on their residence.", "doi": "10.3390/ijerph19148261", "pmid": "35886118", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19148261"}, {"db": "pmc", "key": "PMC9317312"}], "notes": [], "created": "2022-08-12T08:36:15.802Z", "modified": "2022-08-12T08:36:15.959Z"}, {"entity": "publication", "iuid": "5f8f810d6ce14398a6309fbb26311dca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f8f810d6ce14398a6309fbb26311dca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f8f810d6ce14398a6309fbb26311dca"}}, "title": "Fighting social isolation in times of pandemic COVID-19: the role of video calls for older hospitalized patients.", "authors": [{"family": "D\u00fcrst", "given": "Anne-V\u00e9ronique", "initials": "AV"}, {"family": "Graf", "given": "Christophe E", "initials": "CE"}, {"family": "Ruggiero", "given": "Carmelinda", "initials": "C"}, {"family": "Zekry", "given": "Dina", "initials": "D"}, {"family": "Boccardi", "given": "Virginia", "initials": "V"}, {"family": "Monney", "given": "Lauretta", "initials": "L"}, {"family": "Joss", "given": "Isaline", "initials": "I"}, {"family": "Vuilloud", "given": "Karine", "initials": "K"}, {"family": "Vespignani", "given": "Giulia", "initials": "G"}, {"family": "Bosshard", "given": "Wanda", "initials": "W"}, {"family": "Mecocci", "given": "Patrizia", "initials": "P"}, {"family": "Bula", "given": "Christophe J", "initials": "CJ"}, {"family": "D'Amelio", "given": "Patrizia", "initials": "P", "orcid": "0000-0002-4467-8337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c9b0d8ed88f48339d678ee72467a97d.json"}}], "type": "journal article", "published": "2022-07-06", "journal": {"title": "Aging Clin Exp Res", "issn": "1720-8319", "issn-l": "1594-0667"}, "abstract": "Loneliness and social isolation are associated with anxiety and psychological discomfort, especially amongst the oldest and fragile persons.\n\nSILVER evaluates the acceptance of video calls by old hospitalized patients and their relatives during the ban on visits due to the COVID-19. Moreover, SILVER evaluates if the use of different communication technology is associated with different outcomes in terms of anxiety, fear of self and of others' death and mood.\n\nSILVER is an observational multicentre study. Patients hospitalized in two geriatric units in Switzerland and in one orthogeriatric unit in Italy and their relatives were enrolled. Participants can freely choose to use phone or video calls and were evaluated over a week. We measured anxiety, fear of death and mood at baseline and at the end of the study with standard scales. The use of video or phone calls was associated to a change in these parameters by two-way ANOVA for repeated measures.\n\nSixty-four patients and relatives were enrolled, 26.5% used phone calls and 73.5% video calls. The use of video calls was associated with a reduction in anxiety and fear of death in patients and relatives as compared to participants using phone calls.\n\nOld patients and their relatives accepted and appreciated the use of video calls during hospitalization; moreover, participant using video calls appears to be less anxious and less afraid of death.\n\nVideo calls may be a useful communication tool for hospitalized older patients to keep social relationships with relatives and reduce their anxiety and fear of death.\n\nRetrospectively registered on 1st September 2021 in ClinicalTrials.gov (NCT05000099).", "doi": "10.1007/s40520-022-02188-8", "pmid": "35794314", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40520-022-02188-8"}, {"db": "pmc", "key": "PMC9261146"}, {"db": "ClinicalTrials.gov", "key": "NCT05000099"}], "notes": [], "created": "2022-08-17T10:47:20.389Z", "modified": "2022-08-17T10:47:20.446Z"}, {"entity": "publication", "iuid": "9f28d971c8194812a6292e5c9980d210", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f28d971c8194812a6292e5c9980d210.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f28d971c8194812a6292e5c9980d210"}}, "title": "Experiences of How Health and Lifestyle among Individuals with Knee Pain Have Been Influenced during the COVID-19 Pandemic, a HALLOA Study.", "authors": [{"family": "Sunesson", "given": "Evelina", "initials": "E"}, {"family": "Sylwander", "given": "Charlotte", "initials": "C"}, {"family": "Haglund", "given": "Emma", "initials": "E"}, {"family": "Andersson", "given": "Maria L E", "initials": "MLE", "orcid": "0000-0002-0217-5029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c44d890721546b4b14925b6cc9dc805.json"}}, {"family": "Larsson", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-4341-660X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65ac6fdb68864c928da7f0ad3f2d8b8d.json"}}], "type": "journal article", "published": "2022-07-06", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "14", "issn-l": null}, "abstract": "The COVID-19 pandemic has affected the health and lifestyles of both the general population and of vulnerable groups. Individuals with knee pain are recommended to lead an active lifestyle to relieve pain but find it difficult to maintain health and lifestyle compared to the general population due to the cause of chronic pain, impaired physical function, and a diminished quality of life. This study aimed to explore experiences of how health and lifestyle among individuals with knee pain have been influenced during the COVID-19 pandemic. Interviews (n = 19) were conducted in 2021 and analysed with qualitative content analysis. The results showed how individuals with knee pain adjusted their behaviour and revalued their life to maintain health and lifestyle during COVID-19. Adjusted behaviours emerged, such as spending more time at home, becoming digital, and spending more time outdoors, while revaluing life emerged as having a positive outlook on life and sharing responsibility. In conclusion, behaviour was adjusted, and life revalued to manage health and lifestyle during the pandemic. However, the findings are probably similar to the general population, i.e., individuals with knee pain live similar lives as the general population despite knee pain. The results may contribute to alternative ways of maintaining health and lifestyle in various vulnerable groups and may be applied in situations other than the pandemic.", "doi": "10.3390/ijerph19148255", "pmid": "35886110", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19148255"}, {"db": "pmc", "key": "PMC9315972"}], "notes": [], "created": "2022-08-12T08:36:38.200Z", "modified": "2022-08-12T08:36:38.309Z"}, {"entity": "publication", "iuid": "fcf104220f5242e1a52824105e8f0c05", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fcf104220f5242e1a52824105e8f0c05.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fcf104220f5242e1a52824105e8f0c05"}}, "title": "Dengue Infection - Recent Advances in Disease Pathogenesis in the Era of COVID-19.", "authors": [{"family": "Yong", "given": "Yean Kong", "initials": "YK"}, {"family": "Wong", "given": "Won Fen", "initials": "WF"}, {"family": "Vignesh", "given": "Ramachandran", "initials": "R"}, {"family": "Chattopadhyay", "given": "Indranil", "initials": "I"}, {"family": "Velu", "given": "Vijayakumar", "initials": "V"}, {"family": "Tan", "given": "Hong Yien", "initials": "HY"}, {"family": "Zhang", "given": "Ying", "initials": "Y"}, {"family": "Larsson", "given": "Marie", "initials": "M"}, {"family": "Shankar", "given": "Esaki M", "initials": "EM"}], "type": "journal article", "published": "2022-07-06", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "13", "pages": "889196", "issn-l": "1664-3224"}, "abstract": "The dynamics of host-virus interactions, and impairment of the host's immune surveillance by dengue virus (DENV) serotypes largely remain ambiguous. Several experimental and preclinical studies have demonstrated how the virus brings about severe disease by activating immune cells and other key elements of the inflammatory cascade. Plasmablasts are activated during primary and secondary infections, and play a determinative role in severe dengue. The cross-reactivity of DENV immune responses with other flaviviruses can have implications both for cross-protection and severity of disease. The consequences of a cross-reactivity between DENV and anti-SARS-CoV-2 responses are highly relevant in endemic areas. Here, we review the latest progress in the understanding of dengue immunopathogenesis and provide suggestions to the development of target strategies against dengue.", "doi": "10.3389/fimmu.2022.889196", "pmid": "35874775", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC9299105"}], "notes": [], "created": "2022-08-12T08:39:51.534Z", "modified": "2023-06-19T15:34:07.885Z"}, {"entity": "publication", "iuid": "94bdb76111d34f3f9a8895e350216a9a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/94bdb76111d34f3f9a8895e350216a9a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/94bdb76111d34f3f9a8895e350216a9a"}}, "title": "Comparison of drug prescribing before and during the COVID-19 pandemic: A cross-national European study.", "authors": [{"family": "Selke Krulichov\u00e1", "given": "Iva", "initials": "I", "orcid": "0000-0002-6815-0780", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b42258b4310445be9971d83f1863460e.json"}}, {"family": "Selke", "given": "Gisbert W", "initials": "GW", "orcid": "0000-0002-9614-9875", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4960af9c72b4042b9ec3dcd3436d1b2.json"}}, {"family": "Bennie", "given": "Marion", "initials": "M", "orcid": "0000-0002-4046-629X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d920bb014a2414b8171cc8b88abee31.json"}}, {"family": "Hajiebrahimi", "given": "Mohammadhossein", "initials": "M", "orcid": "0000-0001-8118-4988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8338602bdf4d40ffb25713e73b1fc719.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "F\u00fcrst", "given": "Jurij", "initials": "J"}, {"family": "Garuolien\u0117", "given": "Kristina", "initials": "K", "orcid": "0000-0001-7910-0108", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d0b8225059ef405383282d4d9cf02a2d.json"}}, {"family": "Poluzzi", "given": "Elisabetta", "initials": "E", "orcid": "0000-0002-7209-0426", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74229bb087504277a7d2befc7def7291.json"}}, {"family": "Slab\u00fd", "given": "Juraj", "initials": "J"}, {"family": "Yahni", "given": "Corinne Zara", "initials": "CZ", "orcid": "0000-0002-6831-2233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3118450a58744b3e9088d8d2ceb88c66.json"}}, {"family": "Altini", "given": "Mattia", "initials": "M", "orcid": "0000-0002-1809-184X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fdda0cf8e1e741a6be5c7e574d2de956.json"}}, {"family": "Fantini", "given": "Maria Pia", "initials": "MP", "orcid": "0000-0002-3257-6552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2dc69b69cb434e8ea5b7cb2a9267b6f2.json"}}, {"family": "Ko\u010d\u00ed", "given": "V\u00e1clav", "initials": "V"}, {"family": "McTaggart", "given": "Stuart", "initials": "S", "orcid": "0000-0001-6060-9019", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5502fb30f15c465bb0301428f8a0e2ef.json"}}, {"family": "Pontes", "given": "Caridad", "initials": "C", "orcid": "0000-0002-3274-6048", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bb9e906d55141a58f1379cfa81843cf.json"}}, {"family": "Reno", "given": "Chiara", "initials": "C", "orcid": "0000-0002-7933-2141", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9d5f681fdbe4057b795a9a0e73fe282.json"}}, {"family": "Rosa", "given": "Simona", "initials": "S"}, {"family": "Pedrola", "given": "Marta Turu", "initials": "MT", "orcid": "0000-0001-6957-3155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b0ea18522e843ca954888de7cfff1c2.json"}}, {"family": "Udovi\u010d", "given": "Mitja", "initials": "M"}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0003-0531-2516", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4911f8524d634e928a77f67c40e1610d.json"}}], "type": "journal article", "published": "2022-07-06", "journal": {"title": "Pharmacoepidemiol Drug Saf", "issn": "1099-1557", "issn-l": null}, "abstract": "The COVID-19 pandemic had an impact on health care, with disruption to routine clinical care. Our aim was to describe changes in prescription drugs dispensing in the primary and outpatient sectors during the first year of the pandemic across Europe.\n\nWe used routine administrative data on dispensed medicines in eight European countries (five whole countries, three represented by one region each) from January 2017 to March 2021 to compare the first year of the COVID-19 pandemic with the preceding 3 years.\n\nIn the 10 therapeutic subgroups with the highest dispensed volumes across all countries/regions the relative changes between the COVID-19 period and the year before were mostly of a magnitude similar to changes between previous periods. However, for drugs for obstructive airway diseases the changes in the COVID-19 period were stronger in several countries/regions. In all countries/regions a decrease in dispensed DDDs of antibiotics for systemic use (from -39.4% in Romagna to -14.2% in Scotland) and nasal preparations (from -34.4% in Lithuania to -5.7% in Sweden) was observed. We observed a stockpiling effect in the total market in March 2020 in six countries/regions. In Czechia the observed increase was not significant and in Slovenia volumes increased only after the end of the first lockdown. We found an increase in average therapeutic quantity per pack dispensed, which, however, exceeded 5% only in Slovenia, Germany, and Czechia.\n\nThe findings from this first European cross-national comparison show a substantial decrease in dispensed volumes of antibiotics for systemic use in all countries/regions. The results also indicate that the provision of medicines for common chronic conditions was mostly resilient to challenges faced during the pandemic. However, there were notable differences between the countries/regions for some therapeutic areas.", "doi": "10.1002/pds.5509", "pmid": "35791700", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9350215"}], "notes": [], "created": "2022-08-17T10:47:43.816Z", "modified": "2022-08-17T10:47:44.287Z"}, {"entity": "publication", "iuid": "97a4619db82b4311bbd564a3a54b3cd5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/97a4619db82b4311bbd564a3a54b3cd5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/97a4619db82b4311bbd564a3a54b3cd5"}}, "title": "Scandinavian Nurses' Use of Social Media during the COVID-19 Pandemic-A Berger and Luckman Inspired Analysis of a Qualitative Interview Study.", "authors": [{"family": "Glasdam", "given": "Stinne", "initials": "S", "orcid": "0000-0002-0893-3054", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c56787745d04e05ad85e53ce8df6061.json"}}, {"family": "Jacobsen", "given": "Frode F", "initials": "FF"}, {"family": "Hybholt", "given": "Lisbeth", "initials": "L", "orcid": "0000-0002-9764-8940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11f4283601794ccd903ead36c41ce8a3.json"}}, {"family": "Stjernsw\u00e4rd", "given": "Sigrid", "initials": "S", "orcid": "0000-0002-7152-9206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cda8ee3ae8564252aa6ffe2ab219ada8.json"}}], "type": "journal article", "published": "2022-07-05", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "volume": "10", "issue": "7", "issn-l": null}, "abstract": "There is a knowledge gap about nurses' use of social media in relation to and during the COVID-19 pandemic, which demands the upholding of a physical distance to other people, including patients and their relatives. The study aims to explore how nurses in the Scandinavian countries used social media for professional purposes in relation to the first 15 months of the COVID-19 pandemic. Qualitative, semi-structured interviews with 30 nurses in three Scandinavian countries (Denmark, Norway, and Sweden) were conducted. Thematic analyses were made, methodically inspired by Braun and Clarke, and theoretically inspired by Berger and Luckmann's theory about the construction of social reality. The Standards for Reporting Qualitative Research (SRQR) checklist was used. The results showed that social media was a socialisation tool for establishing new routines in clinical practice. Virtual meeting places supported collective understandings of a specific COVID-19 'reality' and 'knowledge' amongst nurses, with the pandemic bringing to the fore the issue of e-professionalism among nurses relating to their clinical practice. However, social media and virtual education were not commonly used in patient contacts. Further, nurses attempted a re-socialisation of the public to proper COVID-19 behaviour through social media. Moreover, blurred boundaries between acting as a private individual and a professional nurse were identified, where ethics of the nursing profession extended to nurses' private lives.", "doi": "10.3390/healthcare10071254", "pmid": "35885781", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "healthcare10071254"}, {"db": "pmc", "key": "PMC9321788"}], "notes": [], "created": "2022-08-12T08:36:58.308Z", "modified": "2022-08-12T08:37:41.053Z"}, {"entity": "publication", "iuid": "1a8b450f998f4242836f0c0e674bfd5c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1a8b450f998f4242836f0c0e674bfd5c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1a8b450f998f4242836f0c0e674bfd5c"}}, "title": "Impact of the COVID-19 pandemic on hernia surgery in a Swedish healthcare region: a population-based cohort study.", "authors": [{"family": "Kollatos", "given": "Christos", "initials": "C", "orcid": "0000-0001-5601-1794", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0c0f32a7ddd4310a7f83271538c234f.json"}}, {"family": "Hanna", "given": "Sarmad", "initials": "S"}, {"family": "Sandblom", "given": "Gabriel", "initials": "G"}], "type": "journal article", "published": "2022-07-05", "journal": {"title": "BMC Surg", "issn": "1471-2482", "volume": "22", "issue": "1", "pages": "260", "issn-l": null}, "abstract": "Swedish healthcare has been reorganised during the COVID-19 pandemic, affecting the availability of surgery for benign conditions. The aim of this study was to determine the effects of COVID-19 on emergency and elective hernia surgery in a Swedish healthcare region.\n\nUsing procedure codes, data from inguinal and ventral hernia procedures performed at the three hospitals in J\u00f6nk\u00f6ping Region, Sweden, from March 1st 2019 to January 31st 2021, were retrieved from a medical database. The cohort was divided into two groups: the COVID-19 group (March 1st 2020-January 31st 2021) and the control group (March 1st 2019-January 31st 2020). Demographic and preoperative data, hernia type, perioperative findings, and type of surgery were analysed.\n\nA total 1329 patients underwent hernia surgery during the study period; 579 were operated during the COVID-19 period and 750 during the control period. The number of emergency ventral hernia repairs increased during the COVID-19 period, but no difference in inguinal hernia repair rate was seen. The characteristics of patients that underwent hernia repair were similar in the two groups. Moreover, the decrease in elective ventral hernia repair rate during the COVID-19 period did not result in a higher risk for strangulation.\n\nThere is no evidence to suggest that the decrease in the number of elective ventral hernia repairs during the COVID-19 period had any impact on the risk for strangulation. Indications for surgery in patients with a symptomatic ventral or inguinal hernia should be carefully evaluated. Studies with greater power and longer follow-up are needed to gain a full understanding of the effects of the COVID-19 pandemic on hernia surgery.", "doi": "10.1186/s12893-022-01698-6", "pmid": "35790926", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12893-022-01698-6"}, {"db": "pmc", "key": "PMC9255440"}], "notes": [], "created": "2022-08-17T13:07:46.085Z", "modified": "2022-08-17T13:08:18.855Z"}, {"entity": "publication", "iuid": "4b3303eb8cc34f53b1dfd91a3ae8dda9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b3303eb8cc34f53b1dfd91a3ae8dda9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b3303eb8cc34f53b1dfd91a3ae8dda9"}}, "title": "Highly perturbed genes and hub genes associated with type 2 diabetes in different tissues of adult humans: a bioinformatics analytic workflow.", "authors": [{"family": "De Silva", "given": "Kushan", "initials": "K"}, {"family": "Demmer", "given": "Ryan T", "initials": "RT"}, {"family": "J\u00f6nsson", "given": "Daniel", "initials": "D"}, {"family": "Mousa", "given": "Aya", "initials": "A"}, {"family": "Forbes", "given": "Andrew", "initials": "A"}, {"family": "Enticott", "given": "Joanne", "initials": "J"}], "type": "journal article", "published": "2022-07-05", "journal": {"title": "Funct Integr Genomics", "issn": "1438-7948", "issn-l": null}, "abstract": "Type 2 diabetes (T2D) has a complex etiology which is not yet fully elucidated. The identification of gene perturbations and hub genes of T2D may deepen our understanding of its genetic basis. We aimed to identify highly perturbed genes and hub genes associated with T2D via an extensive bioinformatics analytic workflow consisting of five steps: systematic review of Gene Expression Omnibus and associated literature; identification and classification of differentially expressed genes (DEGs); identification of highly perturbed genes via meta-analysis; identification of hub genes via network analysis; and downstream analysis of highly perturbed genes and hub genes. Three meta-analytic strategies, random effects model, vote-counting approach, and p value combining approach, were applied. Hub genes were defined as those nodes having above-average betweenness, closeness, and degree in the network. Downstream analyses included gene ontologies, Kyoto Encyclopedia of Genes and Genomes pathways, metabolomics, COVID-19-related gene sets, and Genotype-Tissue Expression profiles. Analysis of 27 eligible microarrays identified 6284 DEGs (4592 downregulated and 1692 upregulated) in four tissue types. Tissue-specific gene expression was significantly greater than tissue non-specific (shared) gene expression. Analyses revealed 79 highly perturbed genes and 28 hub genes. Downstream analyses identified enrichments of shared genes with certain other diabetes phenotypes; insulin synthesis and action-related pathways and metabolomics; mechanistic associations with apoptosis and immunity-related pathways; COVID-19-related gene sets; and cell types demonstrating over- and under-expression of marker genes of T2D. Our approach provided valuable insights on T2D pathogenesis and pathophysiological manifestations. Broader utility of this pipeline beyond T2D is envisaged.", "doi": "10.1007/s10142-022-00881-5", "pmid": "35788821", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10142-022-00881-5"}, {"db": "pmc", "key": "PMC9255467"}], "notes": [], "created": "2022-08-17T13:09:22.836Z", "modified": "2022-08-17T13:09:50.558Z"}, {"entity": "publication", "iuid": "eb17fcce8461418a8c60d3476e72b39f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb17fcce8461418a8c60d3476e72b39f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb17fcce8461418a8c60d3476e72b39f"}}, "title": "Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency.", "authors": [{"family": "Campbell", "given": "Tessa Mollie", "initials": "TM", "orcid": "0000-0002-7737-2123", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8acc313f985d4822bf652289f0eb1b22.json"}}, {"family": "Liu", "given": "Zhiyong", "initials": "Z", "orcid": "0000-0001-6473-348X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d7b2869a5874679b1b6fdccade088a2.json"}}, {"family": "Zhang", "given": "Qian", "initials": "Q", "orcid": "0000-0002-9040-3289", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/341c0cb0fa7d41448e55344c82d68358.json"}}, {"family": "Moncada-Velez", "given": "Marcela", "initials": "M", "orcid": "0000-0002-3073-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c543a8539a6430b8ff5cd9cf5875bf9.json"}}, {"family": "Covill", "given": "Laura E", "initials": "LE", "orcid": "0000-0002-5086-9877", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12f826545b264c1d855a84c5fc3b73bd.json"}}, {"family": "Zhang", "given": "Peng", "initials": "P", "orcid": "0000-0002-6129-567X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ff2f497bd7841b7994dbdf8d2369a4e.json"}}, {"family": "Alavi Darazam", "given": "Ilad", "initials": "I", "orcid": "0000-0002-4440-335X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e747bb463d434cc8b586845f4609391e.json"}}, {"family": "Bastard", "given": "Paul", "initials": "P", "orcid": "0000-0002-5926-8437", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e3388c840d04a25824530a9bf999f01.json"}}, {"family": "Bizien", "given": "Lucy", "initials": "L", "orcid": "0000-0001-9163-9122", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ffde5891cfed41db9dc0265155576cc4.json"}}, {"family": "Bucciol", "given": "Giorgia", "initials": "G", "orcid": "0000-0001-5004-0738", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fde316a981d84407a32dca71fd6f39ba.json"}}, {"family": "Lind Enoksson", "given": "Sara", "initials": "S", "orcid": "0000-0002-0359-8824", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59b33d03efb841f89d3aa2d89618ff6c.json"}}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E"}, {"family": "Karabela", "given": "\u015eemsi Nur", "initials": "\u015eN", "orcid": "0000-0002-7358-9157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c50d261245743539a5813daffcaab72.json"}}, {"family": "Khan", "given": "Taushif", "initials": "T", "orcid": "0000-0002-7917-8965", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b38d5757c43448c3bf12179d4daaf6c2.json"}}, {"family": "Kendir-Demirkol", "given": "Yasemin", "initials": "Y", "orcid": "0000-0003-2562-3004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a31edf9803d748fea64cfd524f2cfe45.json"}}, {"family": "Arias", "given": "Andres Augusto", "initials": "AA", "orcid": "0000-0002-9478-8403", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd8725e3260449938376f721b1202424.json"}}, {"family": "Mansouri", "given": "Davood", "initials": "D", "orcid": "0000-0002-0564-8282", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5bd15b582b93449aaf4dc5cf76428ae9.json"}}, {"family": "Marits", "given": "Per", "initials": "P", "orcid": "0000-0003-2439-5687", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11e1e104844f49e3acadd1c573578941.json"}}, {"family": "Marr", "given": "Nico", "initials": "N", "orcid": "0000-0002-1927-7072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6b7acf92c1041aca93130dc97b1d2f8.json"}}, {"family": "Migeotte", "given": "Isabelle", "initials": "I", "orcid": "0000-0002-8972-8211", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43cd209fd75647fcbe0bd85bc8b94b19.json"}}, {"family": "Moens", "given": "Leen", "initials": "L", "orcid": "0000-0002-5347-6526", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49147a953e1c4721bd0181e5d0a3dafb.json"}}, {"family": "Ozcelik", "given": "Tayfun", "initials": "T", "orcid": "0000-0001-5937-1082", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6665d35db77044aa847a5f394332bb86.json"}}, {"family": "Pellier", "given": "Isabelle", "initials": "I", "orcid": "0000-0002-7988-4712", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/da3596d83f504628a6f4d86150486cbe.json"}}, {"family": "Sendel", "given": "Anton", "initials": "A", "orcid": "0000-0003-4410-3418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e1d9e27c0334858b83da8fdeeac0f9b.json"}}, {"family": "Shahrooei", "given": "Mohammad", "initials": "M", "orcid": "0000-0002-4974-3441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/165bdcfd868e4bd6b7adf371b9d4124f.json"}}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE", "orcid": "0000-0003-1907-3392", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26a3bf24bd044fbda8ffa0c89974bdfe.json"}}, {"family": "Vandernoot", "given": "Isabelle", "initials": "I", "orcid": "0000-0001-8084-7858", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b424cad4625b4b1eb4d901e206f0aa72.json"}}, {"family": "Willekens", "given": "Karen", "initials": "K", "orcid": "0000-0003-2338-5778", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/946e9a2c438f46f5ac816e827c5d8248.json"}}, {"family": "COVID Human Genetic Effort", "given": "", "initials": ""}, {"family": "Bergman", "given": "Peter", "initials": "P", "orcid": "0000-0003-3306-3713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15b7290255814a7b9a1a97c3cdb2fc26.json"}}, {"family": "Abel", "given": "Laurent", "initials": "L", "orcid": "0000-0001-7016-6493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fd6c4593c8c492a8dad8e49cb7a832a.json"}}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5369fe152ac94b5a81d4f913d85940a7.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL", "orcid": "0000-0002-7782-4169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1aca66ab7c39465faf2de03fa8a6722f.json"}}, {"family": "Meyts", "given": "Isabelle", "initials": "I", "orcid": "0000-0003-1214-0302", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a5399449f4c4d338b683632944008fb.json"}}, {"family": "Bryceson", "given": "Yenan T", "initials": "YT", "orcid": "0000-0002-7783-9934", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e66a62e856374a029c8446e863894afe.json"}}], "type": "journal article", "published": "2022-07-04", "journal": {"title": "J Exp Med", "issn": "1540-9538", "volume": "219", "issue": "7", "issn-l": null}, "abstract": "Autosomal recessive IRF7 deficiency was previously reported in three patients with single critical influenza or COVID-19 pneumonia episodes. The patients' fibroblasts and plasmacytoid dendritic cells produced no detectable type I and III IFNs, except IFN-\u03b2. Having discovered four new patients, we describe the genetic, immunological, and clinical features of seven IRF7-deficient patients from six families and five ancestries. Five were homozygous and two were compound heterozygous for IRF7 variants. Patients typically had one episode of pulmonary viral disease. Age at onset was surprisingly broad, from 6 mo to 50 yr (mean age 29 yr). The respiratory viruses implicated included SARS-CoV-2, influenza virus, respiratory syncytial virus, and adenovirus. Serological analyses indicated previous infections with many common viruses. Cellular analyses revealed strong antiviral immunity and expanded populations of influenza- and SARS-CoV-2-specific memory CD4+ and CD8+ T cells. IRF7-deficient individuals are prone to viral infections of the respiratory tract but are otherwise healthy, potentially due to residual IFN-\u03b2 and compensatory adaptive immunity.", "doi": "10.1084/jem.20220202", "pmid": "35670811", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "213267"}], "notes": [], "created": "2022-06-20T19:32:16.154Z", "modified": "2022-06-20T19:32:16.705Z"}, {"entity": "publication", "iuid": "69969fa1ecae46f88d17372796e6b72c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69969fa1ecae46f88d17372796e6b72c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69969fa1ecae46f88d17372796e6b72c"}}, "title": "A qualitative study on mothers' experiences attending an online infant massage class: \"It is funny! I feel close to my baby!\"", "authors": [{"family": "Khuzaiyah", "given": "Siti", "initials": "S"}, {"family": "Adnani", "given": "Qorinah Estiningtyas Sakilah", "initials": "QES"}, {"family": "Chabibah", "given": "Nur", "initials": "N"}, {"family": "Khanifah", "given": "Milatun", "initials": "M"}, {"family": "Lee", "given": "Ka Yiu", "initials": "KY"}], "type": "journal article", "published": "2022-07-04", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "volume": "21", "issue": "1", "pages": "175", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic impacts maternal and perinatal health. Fear of COVID-19 transmission may lead to psychological disorders among mothers, such as anxiety and depression, which might affect the infant's health. Innovation is needed to address problems related to this condition. This study aimed to explore the experiences of mothers who had attended online infant massage classes. METHODS: This qualitative survey recruited 12 Indonesian mothers who had infants aged < 12 months and joined the online infant massage class. An open-ended question form was used to collect data, which were analyzed using thematic content analysis.\n\nThere were six themes related to the experiences of mothers attending online infant massage classes: favorite session, new knowledge and skills, benefits, barriers during infant massage class, factors related to infant massage practice, and mother's hope.\n\nMothers had a good experience learning infant massage and had better interaction with their infants after the class. The findings show that an online infant massage class could benefit both mothers and infants.", "doi": "10.1186/s12912-022-00952-9", "pmid": "35787698", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12912-022-00952-9"}, {"db": "pmc", "key": "PMC9251925"}], "notes": [], "created": "2022-08-17T13:10:25.816Z", "modified": "2022-08-17T13:11:04.406Z"}, {"entity": "publication", "iuid": "689945ec3e6e417d9ef5a3de0de8f486", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/689945ec3e6e417d9ef5a3de0de8f486.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/689945ec3e6e417d9ef5a3de0de8f486"}}, "title": "The Effect of the COVID-19 Pandemic in Intestinal Rehabilitation and Transplant Patients: Initial Results of the Intestinal Rehabilitation and Transplant Association's International Survey.", "authors": [{"family": "Segovia", "given": "Maria", "initials": "M"}, {"family": "Fernandez", "given": "Maria Florencia", "initials": "MF"}, {"family": "Rumbo", "given": "Carolina", "initials": "C"}, {"family": "Zanfi", "given": "Chiara", "initials": "C"}, {"family": "Herlenius", "given": "Gustaf", "initials": "G"}, {"family": "Testro", "given": "Adam", "initials": "A"}, {"family": "Sharkey", "given": "Lisa", "initials": "L"}, {"family": "Braun", "given": "Felix", "initials": "F"}, {"family": "Jafri", "given": "Syed-Mohammed", "initials": "SM"}, {"family": "Vilca Melendez", "given": "Hector", "initials": "H"}, {"family": "Sanchez Claria", "given": "Rodrigo", "initials": "R"}, {"family": "Ceulemans", "given": "Laurens J", "initials": "LJ"}, {"family": "Hibi", "given": "Taizo", "initials": "T"}, {"family": "Solar", "given": "Hector", "initials": "H"}, {"family": "Ramisch", "given": "Diego", "initials": "D"}, {"family": "Noel", "given": "Gillian", "initials": "G"}, {"family": "Yap", "given": "Jason", "initials": "J"}, {"family": "Dijkstra", "given": "Gerard", "initials": "G"}, {"family": "Schiano", "given": "Thomas", "initials": "T"}, {"family": "Friend", "given": "Peter", "initials": "P"}, {"family": "Lacaille", "given": "Florence", "initials": "F"}, {"family": "Sudan", "given": "Debra", "initials": "D"}, {"family": "Mazariegos", "given": "George", "initials": "G"}, {"family": "Horslen", "given": "Simon", "initials": "S"}, {"family": "Gondolesi", "given": "Gabriel E", "initials": "GE"}], "type": "journal article", "published": "2022-07-01", "journal": {"title": "Transplantation", "issn": "1534-6080", "volume": "106", "issue": "7", "pages": "1289-1292", "issn-l": null}, "abstract": null, "doi": "10.1097/TP.0000000000004112", "pmid": "35731148", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00007890-202207000-00001"}, {"db": "pmc", "key": "PMC9213053"}], "notes": [], "created": "2022-08-17T13:06:38.928Z", "modified": "2022-08-17T13:06:38.942Z"}, {"entity": "publication", "iuid": "0eaabc4df5484e08b432df99ba66bab0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0eaabc4df5484e08b432df99ba66bab0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0eaabc4df5484e08b432df99ba66bab0"}}, "title": "Postacute elevation of D-dimer levels in severe acute respiratory syndrome coronavirus 2-positive nonhospitalized patients with mild symptoms.", "authors": [{"family": "Folkman", "given": "Rebecca", "initials": "R"}, {"family": "Kamal", "given": "Habiba", "initials": "H"}, {"family": "Ahl", "given": "Marcus", "initials": "M"}, {"family": "Szum", "given": "Adrian", "initials": "A"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Aleman", "given": "Soo", "initials": "S"}], "type": "journal article", "published": "2022-07-01", "journal": {"title": "Blood Coagul Fibrinolysis", "issn": "1473-5733", "volume": "33", "issue": "5", "pages": "285-287", "issn-l": null}, "abstract": null, "doi": "10.1097/MBC.0000000000001111", "pmid": "35703244", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00001721-990000000-00001"}], "notes": [], "created": "2022-08-17T12:59:42.144Z", "modified": "2022-08-17T13:00:05.206Z"}, {"entity": "publication", "iuid": "8f5a89f6b1bb484b8c9ddef1e8e7ec67", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f5a89f6b1bb484b8c9ddef1e8e7ec67.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f5a89f6b1bb484b8c9ddef1e8e7ec67"}}, "title": "Multidomain interventions for risk reduction and prevention of cognitive decline and dementia: current developments.", "authors": [{"family": "R\u00f6hr", "given": "Susanne", "initials": "S"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Mangialasche", "given": "Francesca", "initials": "F"}, {"family": "Ngandu", "given": "Tiia", "initials": "T"}, {"family": "Riedel-Heller", "given": "Steffi G", "initials": "SG"}], "type": "journal article", "published": "2022-07-01", "journal": {"title": "Curr Opin Psychiatry", "issn": "1473-6578", "volume": "35", "issue": "4", "pages": "285-292", "issn-l": null}, "abstract": "The potential for dementia prevention is deemed substantial if modifiable risk factors were addressed. First large-scale multidomain lifestyle interventions aiming at reducing risk of cognitive decline and dementia have yielded mixed but promising evidence.\n\nDespite the impact of the COVID-19 pandemic on trials conduction, causing interruptions and delays, the research landscape on multidomain interventions is growing rapidly. The successful Finish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) has led to an adaptation of the FINGER model in trials underway or being planned in over 40 countries. Recent studies identified barriers and facilitators of and adherence to multidomain interventions, showed the suitability of dementia risk scores as surrogate outcomes, and suggested mechanisms. Multidomain interventions are increasingly conducted in the Global South, and study protocols are increasingly testing expanded FINGER models, for example, with pharmacological components, in digital/remote settings and co-designed personalized interventions.\n\nThough results remain mixed, the many ongoing trials will provide more conclusive evidence within the next few years and help to optimize interventions. Continued international collaboration is pivotal to scale and accelerate the development and implementation of effective multidomain interventions as part of larger public health strategies to counteract the global dementia increase.", "doi": "10.1097/YCO.0000000000000792", "pmid": "35703256", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "00001504-990000000-00006"}], "notes": [], "created": "2022-06-20T18:11:52.181Z", "modified": "2022-08-17T12:58:51.225Z"}, {"entity": "publication", "iuid": "bc0b2685b3d34c29bfaf77ecbad868dc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bc0b2685b3d34c29bfaf77ecbad868dc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bc0b2685b3d34c29bfaf77ecbad868dc"}}, "title": "Management of Long COVID-The CoviMouv' Pilot Study: Importance of Adapted Physical Activity for Prolonged Symptoms Following SARS-CoV2 Infection.", "authors": [{"family": "Colas", "given": "Claire", "initials": "C"}, {"family": "Bayle", "given": "Manon", "initials": "M"}, {"family": "Labeix", "given": "Pierre", "initials": "P"}, {"family": "Botelho-Nevers", "given": "Elisabeth", "initials": "E"}, {"family": "Gagneux-Brunon", "given": "Amandine", "initials": "A"}, {"family": "Cazorla", "given": "C\u00e9line", "initials": "C"}, {"family": "Schein", "given": "Flora", "initials": "F"}, {"family": "Breugnon", "given": "Emma", "initials": "E"}, {"family": "Garcin", "given": "Arnauld", "initials": "A"}, {"family": "Feasson", "given": "L\u00e9onard", "initials": "L"}, {"family": "Roche", "given": "Fr\u00e9d\u00e9ric", "initials": "F"}, {"family": "Hupin", "given": "David", "initials": "D"}], "type": "journal article", "published": "2022-07-01", "journal": {"title": "Front Sports Act Living", "issn": "2624-9367", "volume": "4", "pages": "877188", "issn-l": null}, "abstract": "After a COVID-19 infection, some patients have persistent symptoms, the most common is fatigue. To prevent it from becoming chronic (post-COVID-19 syndrome), early management before 3 months could be useful. Exercise and education are recommended.\n\nTo assess fatigue in patients with prolonged symptoms after COVID-19 infection and who received a mixed program of remote adapted physical activity and therapeutic education. The secondary objective was to evaluate the efficacy and safety of this training method thanks to aerobic and anaerobic parameters.\n\n\"CoviMouv': From Coaching in Visual to Mouv in real\" is a nonrandomized controlled pilot study. Patients in telerehabilitation followed 12 remote exercise sessions and 3 therapeutic education workshops. Patients on traditional rehabilitation followed their program with a community-based physiotherapist.\n\nFatigue was reduced after the one-month intervention in both groups (p = 0.010). The majority of aerobic parameters were significantly improved, e.g., maximal oxygen uptake (p = 0.005), walking distance (p = 0.019) or hyperventilation values (p = 0.035). The anaerobic parameter was not improved (p = 0.400). No adverse event was declared.\n\nTelerehabilitation is a good alternative when a face-to-face program is not possible. This care at an early stage of the disease could help prevent the chronicity of post-COVID-19 symptoms and the installation of vicious circles of physical deconditioning. A larger study would be necessary.", "doi": "10.3389/fspor.2022.877188", "pmid": "35847457", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9283867"}], "notes": [], "created": "2022-08-12T08:52:50.981Z", "modified": "2022-08-12T08:52:50.987Z"}, {"entity": "publication", "iuid": "e82f7989e13243b19c9ab5812b957407", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e82f7989e13243b19c9ab5812b957407.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e82f7989e13243b19c9ab5812b957407"}}, "title": "Decision support-tools for early detection of infection in older people (aged> 65 years): a scoping review.", "authors": [{"family": "Masot", "given": "Olga", "initials": "O"}, {"family": "Cox", "given": "Anna", "initials": "A"}, {"family": "Mold", "given": "Freda", "initials": "F"}, {"family": "Sund-Levander", "given": "M\u00e4rtha", "initials": "M"}, {"family": "Tingstr\u00f6m", "given": "Pia", "initials": "P"}, {"family": "Boersema", "given": "Geertien Christelle", "initials": "GC"}, {"family": "Botigu\u00e9", "given": "Teresa", "initials": "T"}, {"family": "Daltrey", "given": "Julie", "initials": "J"}, {"family": "Hughes", "given": "Karen", "initials": "K"}, {"family": "Mayhorn", "given": "Christopher B", "initials": "CB"}, {"family": "Montgomery", "given": "Amy", "initials": "A"}, {"family": "Mullan", "given": "Judy", "initials": "J"}, {"family": "Carey", "given": "Nicola", "initials": "N"}], "type": "journal article", "published": "2022-07-01", "journal": {"title": "BMC Geriatr", "issn": "1471-2318", "volume": "22", "issue": "1", "pages": "552", "issn-l": null}, "abstract": "Infection is more frequent, and serious in people aged > 65 as they experience non-specific signs and symptoms delaying diagnosis and prompt treatment. Monitoring signs and symptoms using decision support tools (DST) is one approach that could help improve early detection ensuring timely treatment and effective care.\n\nTo identify and analyse decision support tools available to support detection of infection in older people (> 65 years).\n\nA scoping review of the literature 2010-2021 following Arksey and O'Malley (2005) framework and PRISMA-ScR guidelines. A search of MEDLINE, Cochrane, EMBASE, PubMed, CINAHL, Scopus and PsycINFO using terms to identify decision support tools for detection of infection in people > 65 years was conducted, supplemented with manual searches.\n\nSeventeen papers, reporting varying stages of development of different DSTs were analysed. DSTs largely focussed on specific types of infection i.e. urine, respiratory, sepsis and were frequently hospital based (n = 9) for use by physicians. Four DSTs had been developed in nursing homes and one a care home, two of which explored detection of non- specific infection.\n\nDSTs provide an opportunity to ensure a consistent approach to early detection of infection supporting prompt action and treatment, thus avoiding emergency hospital admissions. A lack of consideration regarding their implementation in practice means that any attempt to create an optimal validated and tested DST for infection detection will be impeded. This absence may ultimately affect the ability of the workforce to provide more effective and timely care, particularly during the current covid-19 pandemic.", "doi": "10.1186/s12877-022-03218-w", "pmid": "35778707", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12877-022-03218-w"}, {"db": "pmc", "key": "PMC9247966"}], "notes": [], "created": "2022-08-17T13:12:07.701Z", "modified": "2022-08-17T13:12:07.714Z"}, {"entity": "publication", "iuid": "17f887a93df245fbb3c3380cb298d54e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/17f887a93df245fbb3c3380cb298d54e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/17f887a93df245fbb3c3380cb298d54e"}}, "title": "Chemistry of Protein-Phenolic Interactions Toward the Microbiota and Microbial Infections.", "authors": [{"family": "Yilmaz", "given": "Hilal", "initials": "H"}, {"family": "Gultekin Subasi", "given": "Busra", "initials": "B"}, {"family": "Celebioglu", "given": "Hasan Ufuk", "initials": "HU"}, {"family": "Ozdal", "given": "Tugba", "initials": "T"}, {"family": "Capanoglu", "given": "Esra", "initials": "E"}], "type": "journal article", "published": "2022-07-01", "journal": {"title": "Front Nutr", "issn": "2296-861X", "volume": "9", "pages": "914118", "issn-l": null}, "abstract": "Along with health concerns, interest in plants as food and bioactive phytochemical sources has been increased in the last few decades. Phytochemicals as secondary plant metabolites have been the subject of many studies in different fields. Breakthrough for research interest on this topic is re-juvenilized with rising relevance in this global pandemics' era. The recent COVID-19 pandemic attracted the attention of people to viral infections and molecular mechanisms behind these infections. Thus, the core of the present review is the interaction of plant phytochemicals with proteins as these interactions can affect the functions of co-existing proteins, especially focusing on microbial proteins. To the best of our knowledge, there is no work covering the protein-phenolic interactions based on their effects on microbiota and microbial infections. The present review collects and defines the recent data, representing the interactions of phenolic compounds -primarily flavonoids and phenolic acids- with various proteins and explores how these molecular-level interactions account for the human health directly and/or indirectly, such as increased antioxidant properties and antimicrobial capabilities. Furthermore, it provides an insight about the further biological activities of interacted protein-phenolic structure from an antiviral activity perspective. The research on the protein-phenolic interaction mechanisms is of great value for guiding how to take advantage of synergistic effects of proteins and polyphenolics for future medical and nutritive approaches and related technologies.", "doi": "10.3389/fnut.2022.914118", "pmid": "35845785", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC9284217"}], "notes": [], "created": "2022-08-12T08:53:09.405Z", "modified": "2022-08-12T08:53:27.220Z"}, {"entity": "publication", "iuid": "87681bb5e6364fdc9e6084741f69928e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87681bb5e6364fdc9e6084741f69928e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87681bb5e6364fdc9e6084741f69928e"}}, "title": "A rapid assessment of take-home naloxone provision during COVID-19 in Europe.", "authors": [{"family": "McDonald", "given": "Rebecca", "initials": "R"}, {"family": "Eide", "given": "Desiree", "initials": "D"}, {"family": "Abel-Ollo", "given": "Katri", "initials": "K"}, {"family": "Barnsdale", "given": "Lee", "initials": "L"}, {"family": "Carter", "given": "Ben", "initials": "B"}, {"family": "Clausen", "given": "Thomas", "initials": "T"}, {"family": "Day", "given": "Ed", "initials": "E"}, {"family": "Fonseca", "given": "Francina", "initials": "F"}, {"family": "Holm\u00e9n", "given": "Elin", "initials": "E"}, {"family": "Horsburgh", "given": "Kirsten", "initials": "K"}, {"family": "Kelleher", "given": "Mike", "initials": "M"}, {"family": "K\u00e5berg", "given": "Martin", "initials": "M"}, {"family": "Ladenhauf", "given": "Martin", "initials": "M"}, {"family": "McAuley", "given": "Andrew", "initials": "A"}, {"family": "Metrebian", "given": "Nicola", "initials": "N"}, {"family": "Neale", "given": "Joanne", "initials": "J"}, {"family": "Parkin", "given": "Stephen", "initials": "S"}, {"family": "Ratcliffe", "given": "Kevin", "initials": "K"}, {"family": "Rintoul", "given": "Chris", "initials": "C"}, {"family": "Smith", "given": "Josie", "initials": "J"}, {"family": "Stifanoviciute", "given": "Viktorija", "initials": "V"}, {"family": "Torrens", "given": "Marta", "initials": "M"}, {"family": "Thiesen", "given": "Henrik", "initials": "H"}, {"family": "Strang", "given": "John", "initials": "J"}], "type": "journal article", "published": "2022-07-01", "journal": {"title": "Int J Drug Policy", "issn": "1873-4758", "volume": "107", "pages": "103787", "issn-l": null}, "abstract": "In March 2020, the World Health Organization declared COVID-19 a global pandemic. In the following weeks, most European countries implemented national lockdowns to mitigate viral spread. Services for people who use drugs had to quickly revise their operating procedures to rearrange service provision while adhering to lockdown requirements. Given the scarcity of literature published on overdose prevention during COVID-19 in Europe, we aimed to examine how these changes to service provision affected take-home naloxone (THN) programmes and naloxone availability across Europe.\n\nBetween November 2020 and January 2021, we conducted a rapid assessment with country experts from European countries that provide THN. We sent country experts a template to report monthly THN distribution data (January 1, 2019-October 31, 2020) and a structured 6-item survey for completion.\n\nResponses were received from 14 of the 15 European countries with THN provision of which 11 participated in the rapid assessment: Austria, Denmark, England, Estonia, Lithuania, Northern Ireland, Norway, Scotland, Spain (Catalonia only), Sweden, and Wales. All reported reduced organisational capacity during COVID-19, and some put into place a range of novel approaches to manage the restrictions on face-to-face service provision. In six countries, the introduction of programme innovation occurred alongside the publication of government guidelines recommending increased THN provision during COVID-19. Eight of the eleven participating countries managed to maintain 2019-level monthly THN distribution rates or even increase provision during the pandemic.\n\nThrough programme innovation supported by public guidelines, many European THN programmes managed to ensure stable or even increased THN provision during the pandemic, despite social distancing and stay-at-home orders affecting client mobility.", "doi": "10.1016/j.drugpo.2022.103787", "pmid": "35849935", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0955-3959(22)00202-X"}, {"db": "pmc", "key": "PMC9247228"}], "notes": [], "created": "2022-08-12T08:52:12.188Z", "modified": "2022-08-12T08:52:12.218Z"}, {"entity": "publication", "iuid": "d56ed86be45b4b0693bf640956ac99e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d56ed86be45b4b0693bf640956ac99e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d56ed86be45b4b0693bf640956ac99e1"}}, "title": "Treatment seeking for alcohol-related issues during the COVID-19 pandemic: An analysis of an addiction-specialized psychiatric treatment facility.", "authors": [{"family": "Andersson", "given": "Mitchell J", "initials": "MJ"}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": "8", "issue": "7", "pages": "e09934", "issn-l": null}, "abstract": "The COVID-19 pandemic and its societal impact may cause long-term behavioral changes in alcohol use due to increased psychological distress, unemployment, and time spent home. The purpose of this study was to determine whether or not the COVID-19 pandemic had a significant impact on treatment seeking for alcohol use disorders and related problems in a Swedish psychiatric treatment facility. Using an interrupted-time-series design on data derived from an addiction-specific psychiatric treatment facility located in Malm\u00f6, Sweden, we hypothesized that treatment seeking would decrease during the pandemic based on previous research identifying limited alcohol availability and affordability, as well as accessibility to treatment centers as influential factors. In addition, we assessed the predictive power of alcohol sales and number of active cases in the region using simple linear regressions. Results indicated that the pandemic had little to no effect on the number of people needing care, however a significant step change was found in treatment seeking patterns for unique female patients during the second wave (October 2020). Regression analyses indicated that alcohol sales and the number of active cases in the region did not significantly predict treatment seeking. A causal relationship between the onset of the pandemic and variation in treatment seeking for alcohol use could not be established. More research is needed to fully understand the pandemic's impact on alcohol use behavior change.", "doi": "10.1016/j.heliyon.2022.e09934", "pmid": "35855398", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(22)01222-1"}, {"db": "pmc", "key": "PMC9279183"}], "notes": [], "created": "2022-08-12T08:48:53.757Z", "modified": "2022-08-12T08:48:53.762Z"}, {"entity": "publication", "iuid": "2d232ef960984198bc09259d47b6c316", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d232ef960984198bc09259d47b6c316.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d232ef960984198bc09259d47b6c316"}}, "title": "Repurposing of antiviral drugs for COVID-19 and impact of repurposed drugs on the nervous system.", "authors": [{"family": "Punekar", "given": "Madhura", "initials": "M"}, {"family": "Kshirsagar", "given": "Manas", "initials": "M"}, {"family": "Tellapragada", "given": "Chaitanya", "initials": "C"}, {"family": "Patil", "given": "Kanchankumar", "initials": "K"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Microb Pathog", "issn": "1096-1208", "volume": "168", "pages": "105608", "issn-l": null}, "abstract": "The recent pandemic, Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has devastated humanity and is continuing to threaten us. Due to the high transmissibility of this pathogen, researchers are still trying to cope with the treatment and prevention of this disease. Few of them were successful in finding cure for COVID-19 by including repurposed drugs in the treatment. In such pandemic situations, when it is nearly impossible to design and implement a new drug target, previously designed antiviral drugs could help against novel viruses, referred to as drug repurposing/redirecting/repositioning or re-profiling. This review describes the current landscape of the repurposing of antiviral drugs for COVID-19 and the impact of these drugs on our nervous system. In some cases, specific antiviral therapy has been notably associated with neurological toxicity, characterized by peripheral neuropathy, neurocognitive and neuropsychiatric effects within the central nervous system (CNS).", "doi": "10.1016/j.micpath.2022.105608", "pmid": "35654381", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0882-4010(22)00221-2"}], "notes": [], "created": "2022-06-21T17:21:10.384Z", "modified": "2022-06-21T17:21:10.420Z"}, {"entity": "publication", "iuid": "f59339d3ad1844a095d84107b01f0f97", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f59339d3ad1844a095d84107b01f0f97.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f59339d3ad1844a095d84107b01f0f97"}}, "title": "Predicting attitudinal and behavioral responses to COVID-19 pandemic using machine learning.", "authors": [{"family": "Pavlovi\u0107", "given": "Tomislav", "initials": "T", "orcid": "0000-0002-4470-3715", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b5a5d7b53914f58ba60821e70539887.json"}}, {"family": "Azevedo", "given": "Flavio", "initials": "F", "orcid": "0000-0001-9000-8513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7864cb0e9bf846d6b69a6a5bf65cbd91.json"}}, {"family": "De", "given": "Koustav", "initials": "K", "orcid": "0000-0001-9562-0672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d6627eccf1d42baa44ed1ab89430f41.json"}}, {"family": "Ria\u00f1o-Moreno", "given": "Juli\u00e1n C", "initials": "JC", "orcid": "0000-0003-4182-0550", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/152a5f53020c49b8bac49dd90ac28253.json"}}, {"family": "Magli\u0107", "given": "Marina", "initials": "M", "orcid": "0000-0002-6851-4601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d8c351f3a484c3690ba0fa55f7cebdb.json"}}, {"family": "Gkinopoulos", "given": "Theofilos", "initials": "T", "orcid": "0000-0003-1070-6245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79f358d2d829449abfbcaee30042cc75.json"}}, {"family": "Donnelly-Kehoe", "given": "Patricio Andreas", "initials": "PA", "orcid": "0000-0002-3738-9537", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1477fc6c8a649d39e2f3f99d2580e95.json"}}, {"family": "Pay\u00e1n-G\u00f3mez", "given": "C\u00e9sar", "initials": "C", "orcid": "0000-0002-0633-1332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f473ea4639241fda23bf7f76ac9fef9.json"}}, {"family": "Huang", "given": "Guanxiong", "initials": "G", "orcid": "0000-0002-8588-1454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a1c0bc719e64cfb968124490fe30f56.json"}}, {"family": "Kantorowicz", "given": "Jaroslaw", "initials": "J", "orcid": "0000-0002-1186-5427", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/848df4a38f424410994e5c106185d6be.json"}}, {"family": "Birtel", "given": "Mich\u00e8le D", "initials": "MD", "orcid": "0000-0002-2383-9197", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d0e795d0cd4435586f09edfabffa510.json"}}, {"family": "Sch\u00f6negger", "given": "Philipp", "initials": "P", "orcid": "0000-0001-9930-487X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35568fb99a374c0a991a4be87eefa994.json"}}, {"family": "Capraro", "given": "Valerio", "initials": "V", "orcid": "0000-0002-0579-0166", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2eb7cac8bce492b93cf98134a322d4c.json"}}, {"family": "Santamar\u00eda-Garc\u00eda", "given": "Hernando", "initials": "H", "orcid": "0000-0001-9422-3579", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40b9f8cec76a4451862823b554f351c6.json"}}, {"family": "Yucel", "given": "Meltem", "initials": "M", "orcid": "0000-0002-7274-5971", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65a44c75ffa1499abea1909977b44e79.json"}}, {"family": "Ibanez", "given": "Agustin", "initials": "A", "orcid": "0000-0001-6758-5101", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4ec1841513243d981ba5cba471bc1d9.json"}}, {"family": "Rathje", "given": "Steve", "initials": "S", "orcid": "0000-0001-6727-571X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/358b4bc86edc4ff395946f7d420d28b8.json"}}, {"family": "Wetter", "given": "Erik", "initials": "E", "orcid": "0000-0002-5821-6651", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2fa438fa71224f4cb513cee60e632925.json"}}, {"family": "Stanojevi\u0107", "given": "Dragan", "initials": "D", "orcid": "0000-0002-3667-2461", "researcher": {"href": 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"initials": "Z", "orcid": "0000-0002-9231-5100", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/976f634ec7ff487a9e886500ff7f52ca.json"}}, {"family": "Mitkidis", "given": "Panagiotis", "initials": "P", "orcid": "0000-0002-9495-7369", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40b0c9405e1d4aef8a53e669fdb8847d.json"}}, {"family": "Cichocka", "given": "Aleksandra", "initials": "A", "orcid": "0000-0003-1703-1586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0cc1202c8fb34d07952c7d99ab43bf87.json"}}, {"family": "Gelfand", "given": "Michele", "initials": "M"}, {"family": "Alfano", "given": "Mark", "initials": "M", "orcid": "0000-0001-5879-8033", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9adf19b051647d19c86bc89ee440988.json"}}, {"family": "Ross", "given": "Robert M", "initials": "RM", "orcid": "0000-0001-8711-1675", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49cb2e4d713844729ee7d64213f3cdbe.json"}}, {"family": "Sj\u00e5stad", "given": "Hallgeir", "initials": "H", "orcid": "0000-0002-8730-1038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9d4b3d4379f4e3bb43607c0ef08f159.json"}}, {"family": "Nezlek", "given": "John B", "initials": "JB", "orcid": "0000-0003-4963-3637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab0b925a3d5b4c3d9f03d141757d41ba.json"}}, {"family": "Cislak", "given": "Aleksandra", "initials": "A", "orcid": "0000-0002-9880-6947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37e0b6640a76467890fed6a7975b031c.json"}}, {"family": "Lockwood", "given": "Patricia", "initials": "P", "orcid": "0000-0001-7195-9559", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d77d4779b0ff456b906f2001dc3aa36f.json"}}, {"family": "Abts", "given": "Koen", "initials": "K", "orcid": "0000-0001-8546-8347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9128fa7c6104fecabd5e4e52b1ce6ee.json"}}, {"family": "Agadullina", "given": "Elena", "initials": "E", "orcid": "0000-0002-1505-1412", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1d55ff13a5b4373abb3aca1376a41b9.json"}}, {"family": "Amodio", "given": "David M", "initials": "DM", "orcid": "0000-0001-7746-0150", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/909d9da1100b49cfb829c88277849da2.json"}}, {"family": "Apps", "given": "Matthew A J", "initials": "MAJ", "orcid": "0000-0001-5793-2202", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd23864c1da2420aab5bc56d02b7f770.json"}}, {"family": "Aruta", "given": "John Jamir Benzon", "initials": "JJB", "orcid": "0000-0003-4155-1063", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc1b14a0e89b4d9cb7f9c977e34a9a67.json"}}, {"family": "Besharati", "given": "Sahba", "initials": "S", "orcid": "0000-0003-2836-7982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8948fcda91f444f89cc8ddcfe4e489d9.json"}}, {"family": "Bor", "given": "Alexander", "initials": "A", "orcid": "0000-0002-2624-9221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/048bdb252beb4b2599b619f41ace6277.json"}}, {"family": "Choma", "given": "Becky", "initials": "B", "orcid": "0000-0002-8286-8983", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/207911cc2901427598e7b5f60bd927da.json"}}, {"family": "Cunningham", "given": "William", "initials": "W"}, {"family": "Ejaz", "given": "Waqas", "initials": "W", "orcid": "0000-0002-2492-4115", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0540fea51e3740068aa543e3e9bfd57e.json"}}, 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"orcid": "0000-0002-0794-7702", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8177b1e630c54506b665af61a4204f3c.json"}}, {"family": "Zwaan", "given": "Rolf A", "initials": "RA", "orcid": "0000-0001-9967-7879", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c6e9acd4b0c4c3881f364b11f0dc8d0.json"}}, {"family": "Boggio", "given": "Paulo Sergio", "initials": "PS", "orcid": "0000-0002-6109-0447", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1a661afdf824fa596f035139880c521.json"}}, {"family": "Whillans", "given": "Ashley", "initials": "A"}, {"family": "Van Lange", "given": "Paul A M", "initials": "PAM", "orcid": "0000-0001-7774-6984", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14e8d477999b4beb9878beb5f7ee3e99.json"}}, {"family": "Prasad", "given": "Rajib", "initials": "R", "orcid": "0000-0003-0913-1624", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22102152292941f183ae692ea2e24a2a.json"}}, {"family": "Onderco", "given": "Michal", "initials": "M", "orcid": "0000-0001-9911-3782", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeef609fb2c44af5b8f38042a590b931.json"}}, {"family": "O'Madagain", "given": "Cathal", "initials": "C", "orcid": "0000-0002-4086-524X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee7ab547d0f146929e7aece70f30cd24.json"}}, {"family": "Nesh-Nash", "given": "Tarik", "initials": "T", "orcid": "0000-0002-5532-9095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b8406427e494a16b95e8e3aebf40345.json"}}, {"family": "Laguna", "given": "Oscar Moreda", "initials": "OM"}, {"family": "Kubin", "given": "Emily", "initials": "E", "orcid": "0000-0003-0606-8594", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bf123de600e4b958365eb744b78825a.json"}}, {"family": "G\u00fcmren", "given": "Mert", "initials": "M", "orcid": "0000-0002-3298-6295", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46f817818fab49a18e8576bbe9775d11.json"}}, {"family": "Fenwick", "given": "Ali", "initials": "A", "orcid": "0000-0002-5412-9745", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f45980f8496c4d039e2bdbb71bdf7a8c.json"}}, {"family": "Ertan", "given": "Arhan S", "initials": "AS", "orcid": "0000-0001-9730-8391", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/459a43a3f47548c3a73d95dbba35127e.json"}}, {"family": "Bernstein", "given": "Michael J", "initials": "MJ", "orcid": "0000-0002-8083-9839", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12779a2d6b544bf994b765780cde0723.json"}}, {"family": "Amara", "given": "Hanane", "initials": "H", "orcid": "0000-0003-0732-2320", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88b038a62a4845d6a7f46f40071a8d42.json"}}, {"family": "Van Bavel", "given": "Jay Joseph", "initials": "JJ", "orcid": "0000-0002-2520-0442", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/344fbd5da7bc4259b3f70839f401c84c.json"}}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "PNAS Nexus", "issn": "2752-6542", "volume": "1", "issue": "3", "pages": "pgac093", "issn-l": null}, "abstract": "At the beginning of 2020, COVID-19 became a global problem. Despite all the efforts to emphasize the relevance of preventive measures, not everyone adhered to them. Thus, learning more about the characteristics determining attitudinal and behavioral responses to the pandemic is crucial to improving future interventions. In this study, we applied machine learning on the multinational data collected by the International Collaboration on the Social and Moral Psychology of COVID-19 (N = 51,404) to test the predictive efficacy of constructs from social, moral, cognitive, and personality psychology, as well as socio-demographic factors, in the attitudinal and behavioral responses to the pandemic. The results point to several valuable insights. Internalized moral identity provided the most consistent predictive contribution-individuals perceiving moral traits as central to their self-concept reported higher adherence to preventive measures. Similar results were found for morality as cooperation, symbolized moral identity, self-control, open-mindedness, and collective narcissism, while the inverse relationship was evident for the endorsement of conspiracy theories. However, we also found a non-neglible variability in the explained variance and predictive contributions with respect to macro-level factors such as the pandemic stage or cultural region. Overall, the results underscore the importance of morality-related and contextual factors in understanding adherence to public health recommendations during the pandemic.", "doi": "10.1093/pnasnexus/pgac093", "pmid": "35990802", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "pgac093"}, {"db": "pmc", "key": "PMC9381137"}], "notes": [], "created": "2022-09-12T18:51:19.761Z", "modified": "2022-09-12T18:51:22.853Z"}, {"entity": "publication", "iuid": "fa42143e23004ff695be370f9d78be58", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa42143e23004ff695be370f9d78be58.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa42143e23004ff695be370f9d78be58"}}, "title": "Living with the aftermaths of a stroke in the era of the COVID-19 pandemic; the significance of home and close surroundings.", "authors": [{"family": "Kyl\u00e9n", "given": "Maya", "initials": "M"}, {"family": "von Koch", "given": "Lena", "initials": "L"}, {"family": "Wottrich", "given": "Annica Wohlin", "initials": "AW"}, {"family": "Elf", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Health Place", "issn": "1873-2054", "volume": "76", "pages": "102852", "issn-l": null}, "abstract": "Stay-at-home recommendations to reduce the spread of the COVID-19 virus have had a major impact on people's everyday lives. However, while the evidence indicates that such recommendations have caused distress, anxiety, and fear among the public, little is known about how persons living with complex health conditions, e.g., disability after stroke, have experienced and handled the situation. We interviewed fourteen participants (7 women, 7 men) aged 61-91 years living in ordinary housing during summer 2020 to explore how people who recovered after a stroke experienced their everyday lives in their homes and close surroundings during the COVID-19 pandemic recommendations. Three intertwined themes were constructed from the narrative data and the iterative thematic analysis: (1) Places within and out of reach, (2) Upholding activities-strategies and structures, and (3) Adapting to new circumstances. The findings suggest that places within reach were important to maintain activities and provide structure in daily life. The participants seemed to make use of their previous experiences of adjusting to new circumstances after stroke when adapting to living under the stay-at-home recommendations. In addition, feeling that they now shared the restrictions with all other people in society seemed to ease their situations. Access to nature and spaces in the close surroundings was essential for staying socially connected and receiving support in daily life. The significance of the home and the neighbourhood for health experiences among people who recently have had a stroke should inform rehabilitation interventions both during and after pandemics and environmental planning.", "doi": "10.1016/j.healthplace.2022.102852", "pmid": "35803042", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1353-8292(22)00113-7"}, {"db": "pmc", "key": "PMC9222220"}], "notes": [], "created": "2022-08-17T10:44:25.664Z", "modified": "2022-08-17T10:44:36.090Z"}, {"entity": "publication", "iuid": "44c5299a78d54745b8e0de0df6e5aaa9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44c5299a78d54745b8e0de0df6e5aaa9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44c5299a78d54745b8e0de0df6e5aaa9"}}, "title": "Impacts of severity of Covid-19 infection on the morbidity and mortality of surgical patients.", "authors": [{"family": "Al Ani", "given": "Amer", "initials": "A"}, {"family": "Tahtamoni", "given": "Rafeef", "initials": "R"}, {"family": "Mohammad", "given": "Yara", "initials": "Y"}, {"family": "Al-Ayoubi", "given": "Fawzi", "initials": "F"}, {"family": "Haider", "given": "Nadeem", "initials": "N"}, {"family": "Al-Mashhadi", "given": "Ammar", "initials": "A"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Ann Med Surg (Lond)", "issn": "2049-0801", "pages": "103910", "volume": "79", "issn-l": null}, "abstract": "One of the challenges of surgery on patients with active SARS-CoV-2(severe acute respiratory syndrome coronavirus 2) infection is the increased risk of postoperative morbidity and mortality.\n\nThis study will describe and compare the postoperative morbidity and mortality in asymptomatic patients or those with mild infection with those with severe COVID-19 infection undergoing elective or and emergency surgery.\n\nThis is a retrospective study of 37 COVID19 patients who had the infection 7 days prior to and 30 days after emergency or elective surgery. Patients were divided to two groups. Group1: the asymptomatic or those with mild infection that is diagnosed just before surgery (14 patients). Group 2: those who were admitted to the hospital because of severe COVID-19 and were operated for COVID-19 related complications (23 patients). Morbidity and mortality of both groups was studied.\n\nThere was no significant difference in gender between the two groups. There were 5 females (2 in group 1, and 3 in group 2) and 32 males (12 in group 1, and 20 in group 2). Mean age for all patients was 49.8years (38 for group 1 and 57 for group2). Median age for all patients was 50 years (37.5 for group 1 and 57 years for group 2). Sepsis developed in 7 patients (1 patient in group 1 and in 6 patients in group 2). Statistically there was no significant difference in occurrence of sepsis between the two groups. There was a significant difference in the intensive care stay between the two groups (higher in group 2). Four deaths were reported in group 1 and fourteen in group 2. Eighteen out of thirty-seven patients died.\n\nSeverity of COVID-19 infection will prolong the hospitalization and ICU stay in surgical patients with no significant effect on mortality.", "doi": "10.1016/j.amsu.2022.103910", "pmid": "35698648", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2049-0801(22)00670-7"}, {"db": "pmc", "key": "PMC9176105"}], "notes": [], "created": "2022-06-20T18:16:44.976Z", "modified": "2022-08-17T13:02:53.070Z"}, {"entity": "publication", "iuid": "66a8f5b641e34e5e903816b561a944a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66a8f5b641e34e5e903816b561a944a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66a8f5b641e34e5e903816b561a944a1"}}, "title": "Immune responses after omicron infection in triple-vaccinated health-care workers with and without previous SARS-CoV-2 infection.", "authors": [{"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Norin", "given": "Nina Greilert", "initials": "NG"}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Garc\u00eda", "given": "Marina", "initials": "M"}, {"family": "Tecleab", "given": "Teghesti", "initials": "T"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Forsell", "given": "Mattias", "initials": "M"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "letter", "published": "2022-07-00", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "issn-l": null, "volume": "22", "issue": "7", "pages": "943-945"}, "abstract": null, "doi": "10.1016/S1473-3099(22)00362-0", "pmid": "35691303", "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9183210"}, {"db": "pii", "key": "S1473-3099(22)00362-0"}], "notes": [], "created": "2022-06-20T18:21:45.781Z", "modified": "2023-06-19T14:27:30.544Z"}, {"entity": "publication", "iuid": "4a9fbf6212c841cc8bc0ff99dfa7f18b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4a9fbf6212c841cc8bc0ff99dfa7f18b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4a9fbf6212c841cc8bc0ff99dfa7f18b"}}, "title": "Follow-up regimes for sick-listed employees: A comparison of nine north-western European countries.", "authors": [{"family": "Ose", "given": "Solveig Osborg", "initials": "SO"}, {"family": "Kaspersen", "given": "Silje Lill", "initials": "SL"}, {"family": "Leinonen", "given": "Taina", "initials": "T"}, {"family": "Verstappen", "given": "Suzanne", "initials": "S"}, {"family": "de Rijk", "given": "Angelique", "initials": "A"}, {"family": "Spasova", "given": "Slavina", "initials": "S"}, {"family": "Hultqvist", "given": "Sara", "initials": "S"}, {"family": "N\u00f8rup", "given": "Iben", "initials": "I"}, {"family": "P\u00e1lsson", "given": "J\u00f3n R", "initials": "JR"}, {"family": "Blume", "given": "Andreas", "initials": "A"}, {"family": "Paternoga", "given": "Mike", "initials": "M"}, {"family": "Kalseth", "given": "Jorid", "initials": "J"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Health Policy", "issn": "0168-8510", "volume": "126", "issue": "7", "pages": "619-631", "issn-l": null}, "abstract": "The Covid-19 pandemic has revealed the importance of social protection systems, including income security, when health problems arise. The aims of this study are to compare the follow-up regimes for sick-listed employees across nine European countries, and to conduct a qualitative assessment of the differences with respect to burden and responsibility sharing between the social protection system, employers and employees. The tendency highlighted is that countries with shorter employer periods of sick-pay typically have stricter follow-up responsibility for employers because, in practice, they become gatekeepers of the public sickness benefit scheme. In Germany and the UK, employers have few requirements for follow-up compared with the Nordic countries because they bear most of the costs of sickness absence themselves. The same applies in Iceland, where employers carry most of the costs and have no obligation to follow up sick-listed employees. The situation in the Netherlands is paradoxical: employers have strict obligations in the follow-up regime even though they cover all the costs of the sick-leave themselves. During the pandemic, the majority of countries have adjusted their sick-pay system and increased coverage to reduce the risk of spreading Covid-19 because employees are going to work sick or when they should self-quarantine, except for the Netherlands and Belgium, which considered that the current schemes were already sufficient to reduce that risk.", "doi": "10.1016/j.healthpol.2022.05.002", "pmid": "35577620", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0168-8510(22)00104-X"}, {"db": "pmc", "key": "PMC9085445"}], "notes": [], "created": "2022-06-21T18:05:44.262Z", "modified": "2022-06-21T18:05:45.486Z"}, {"entity": "publication", "iuid": "07ee362db00f4e4892091f0ed7f26e18", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07ee362db00f4e4892091f0ed7f26e18.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07ee362db00f4e4892091f0ed7f26e18"}}, "title": "Factors associated with clinical progression to severe COVID-19 in people with cystic fibrosis: A global observational study.", "authors": [{"family": "Carr", "given": "Siobh\u00e1n B", "initials": "SB"}, {"family": "McClenaghan", "given": "Elliot", "initials": "E"}, {"family": "Elbert", "given": "Alexander", "initials": "A"}, {"family": "Faro", "given": "Albert", "initials": "A"}, {"family": "Cosgriff", "given": "Rebecca", "initials": "R"}, {"family": "Abdrakhmanov", "given": "Olzhas", "initials": "O"}, {"family": "Brownlee", "given": "Keith", "initials": "K"}, {"family": "Burgel", "given": "Pierre-R\u00e9gis", "initials": "PR"}, {"family": "Byrnes", "given": "Catherine A", "initials": "CA"}, {"family": "Cheng", "given": "Stephanie Y", "initials": "SY"}, {"family": "Colombo", "given": "Carla", "initials": "C"}, {"family": "Corvol", "given": "Harriet", "initials": "H"}, {"family": "Daneau", "given": "G\u00e9raldine", "initials": "G"}, {"family": "Goss", "given": "Christopher H", "initials": "CH"}, {"family": "Gulmans", "given": "Vincent", "initials": "V"}, {"family": "Gutierrez", "given": "Hector", "initials": "H"}, {"family": "Harutyunyan", "given": "Satenik", "initials": "S"}, {"family": "Helmick", "given": "Meagan", "initials": "M"}, {"family": "Jung", "given": "Andreas", "initials": "A"}, {"family": "Kashirskaya", "given": "Nataliya", "initials": "N"}, {"family": "McKone", "given": "Edward", "initials": "E"}, {"family": "Melo", "given": "Joel", "initials": "J"}, {"family": "Middleton", "given": "Peter G", "initials": "PG"}, {"family": "Mondejar-Lopez", "given": "Pedro", "initials": "P"}, {"family": "de Monestrol", "given": "Isabelle", "initials": "I"}, {"family": "N\u00e4hrlich", "given": "Lutz", "initials": "L"}, {"family": "Padoan", "given": "Rita", "initials": "R"}, {"family": "Parker", "given": "Megan", "initials": "M"}, {"family": "Pastor-Vivero", "given": "M Dolores", "initials": "MD"}, {"family": "Rizvi", "given": "Samar", "initials": "S"}, {"family": "Ruseckaite", "given": "Rasa", "initials": "R"}, {"family": "Salvatore", "given": "Marco", "initials": "M"}, {"family": "da Silva-Filho", "given": "Luiz Vicente R F", "initials": "LVRF"}, {"family": "Versmessen", "given": "Nick", "initials": "N"}, {"family": "Zampoli", "given": "Marco", "initials": "M"}, {"family": "Marshall", "given": "Bruce C", "initials": "BC"}, {"family": "Stephenson", "given": "Anne L", "initials": "AL"}, {"family": "CF Registry Global Collaboration", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "J Cyst Fibros", "issn": "1873-5010", "volume": "21", "issue": "4", "pages": "e221-e231", "issn-l": null}, "abstract": "This international study aimed to characterise the impact of acute SARS-CoV-2 infection in people with cystic fibrosis and investigate factors associated with severe outcomes. Methods Data from 22 countries prior to 13th December 2020 and the introduction of vaccines were included. It was de-identified and included patient demographics, clinical characteristics, treatments, outcomes and sequalae following SARS-CoV-2 infection. Multivariable logistic regression was used to investigate factors associated with clinical progression to severe COVID-19, using the primary outcome of hospitalisation with supplemental oxygen.\n\nSARS-CoV-2 was reported in 1555 people with CF, 1452 were included in the analysis. One third were aged <18 years, and 9.4% were solid-organ transplant recipients. 74.5% were symptomatic and 22% were admitted to hospital. In the non-transplanted cohort, 39.5% of patients with ppFEV1<40% were hospitalised with oxygen verses 3.2% with ppFEV >70%: a 17-fold increase in odds. Worse outcomes were independently associated with older age, non-white race, underweight body mass index, and CF-related diabetes. Prescription of highly effective CFTR modulator therapies was associated with a significantly reduced odds of being hospitalised with oxygen (AOR 0.43 95%CI 0.31-0.60 p<0.001). Transplanted patients were hospitalised with supplemental oxygen therapy (21.9%) more often than non-transplanted (8.8%) and was independently associated with the primary outcome (Adjusted OR 2.45 95%CI 1.27-4.71 p=0.007).\n\nThis is the first study to show that there is a protective effect from the use of CFTR modulator therapy and that people with CF from an ethnic minority are at more risk of severe infection with SARS-CoV-2.", "doi": "10.1016/j.jcf.2022.06.006", "pmid": "35753987", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1569-1993(22)00593-8"}, {"db": "pmc", "key": "PMC9189103"}], "notes": [], "created": "2022-08-19T05:39:10.105Z", "modified": "2022-08-19T05:39:10.118Z"}, {"entity": "publication", "iuid": "2736ce22a4c84406aff2878bf7382293", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2736ce22a4c84406aff2878bf7382293.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2736ce22a4c84406aff2878bf7382293"}}, "title": "Evaluation of a pneumonia multiplex PCR panel for detection of bacterial respiratory tract pathogens from serial specimens collected from hospitalized COVID-19 patients.", "authors": [{"family": "Tellapragada", "given": "Chaitanya", "initials": "C"}, {"family": "Ydsten", "given": "Karin Andersson", "initials": "KA"}, {"family": "Ternhag", "given": "Anders", "initials": "A"}, {"family": "Giske", "given": "Christian G", "initials": "CG"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Eur J Clin Microbiol Infect Dis", "issn": "1435-4373", "volume": "41", "issue": "7", "pages": "1093-1098", "issn-l": null}, "abstract": "We investigated the concordance between the Unyvero Hospitalized Pneumonia (HPN) application and quantitative culture for detection of bacterial pathogens from serial lower respiratory tract (LRT) specimens collected from the same subject. Comparison of results from HPN application and culture was evaluated using 69 LRT samples from 27 subjects, using two evaluation approaches. False positive detections by the HPN application was 29% (20/69) in Evaluation I vs 10% (7/68) in Evaluation II. Additional pathogens detected by the HPN application could be confirmed in many instances by culture positivity for the same organism from previous or subsequent samples from the same subject.", "doi": "10.1007/s10096-022-04466-9", "pmid": "35727430", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10096-022-04466-9"}, {"db": "pmc", "key": "PMC9210330"}], "notes": [], "created": "2022-08-17T13:05:50.911Z", "modified": "2022-08-17T13:05:50.925Z"}, {"entity": "publication", "iuid": "6df11f853339494a86fd28b53ff34350", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6df11f853339494a86fd28b53ff34350.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6df11f853339494a86fd28b53ff34350"}}, "title": "Estimation of COVID-19 vaccine effectiveness against hospitalisation in individuals aged \u2265 65 years using electronic health registries; a pilot study in four EU/EEA countries, October 2021 to March 2022.", "authors": [{"family": "Sent\u00eds", "given": "Alexis", "initials": "A"}, {"family": "Kislaya", "given": "Irina", "initials": "I"}, {"family": "Nicolay", "given": "Nathalie", "initials": "N"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}, {"family": "Starrfelt", "given": "Jostein", "initials": "J"}, {"family": "Mart\u00ednez-Baz", "given": "Iv\u00e1n", "initials": "I"}, {"family": "Castilla", "given": "Jes\u00fas", "initials": "J"}, {"family": "Nielsen", "given": "Katrine Finderup", "initials": "KF"}, {"family": "Hansen", "given": "Christian Holm", "initials": "CH"}, {"family": "Emborg", "given": "Hanne-Dorthe", "initials": "HD"}, {"family": "Nardone", "given": "Anthony", "initials": "A"}, {"family": "Derrough", "given": "Tarik", "initials": "T"}, {"family": "Valenciano", "given": "Marta", "initials": "M"}, {"family": "Nunes", "given": "Baltazar", "initials": "B"}, {"family": "Monge", "given": "Susana", "initials": "S"}, {"family": "VEBIS-Lot4 working group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "27", "issue": "30", "issn-l": null}, "abstract": "By employing a common protocol and data from electronic health registries in Denmark, Navarre (Spain), Norway and Portugal, we estimated vaccine effectiveness (VE) against hospitalisation due to COVID-19 in individuals aged \u2265 65 years old, without previous documented infection, between October 2021 and March 2022. VE was higher in 65-79-year-olds compared with \u2265 80-year-olds and in those who received a booster compared with those who were primary vaccinated. VE remained high (ca 80%) between \u2265 12 and < 24 weeks after the first booster administration, and after Omicron became dominant.", "doi": "10.2807/1560-7917.ES.2022.27.30.2200551", "pmid": "35904059", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9336167"}], "notes": [], "created": "2022-08-12T08:31:50.769Z", "modified": "2022-08-12T08:31:50.775Z"}, {"entity": "publication", "iuid": "257be128e37140f4add47ae92431b41f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/257be128e37140f4add47ae92431b41f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/257be128e37140f4add47ae92431b41f"}}, "title": "Digital tools in allergy and respiratory care.", "authors": [{"family": "Verhoeven", "given": "Elisabeth", "initials": "E"}, {"family": "Rouadi", "given": "Philip", "initials": "P"}, {"family": "Jaoude", "given": "Eliane Abou", "initials": "EA"}, {"family": "Abouzakouk", "given": "Mohamed", "initials": "M"}, {"family": "Ansotegui", "given": "Ignacio", "initials": "I"}, {"family": "Al-Ahmad", "given": "Mona", "initials": "M"}, {"family": "Al-Nesf", "given": "Maryam Ali", "initials": "MA"}, {"family": "Azar", "given": "Cecilio", "initials": "C"}, {"family": "Bahna", "given": "Sami", "initials": "S"}, {"family": "Cuervo-Pardo", "given": "Lyda", "initials": "L"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}, {"family": "Douagui", "given": "Habib", "initials": "H"}, {"family": "Maximiliano G\u00f3mez", "given": "R", "initials": "R"}, {"family": "D\u00edaz", "given": "Sandra Gonz\u00e1lez", "initials": "SG"}, {"family": "Han", "given": "Joseph K", "initials": "JK"}, {"family": "Idriss", "given": "Samar", "initials": "S"}, {"family": "Irani", "given": "Carla", "initials": "C"}, {"family": "Karam", "given": "Marilyn", "initials": "M"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Nsouli", "given": "Talal", "initials": "T"}, {"family": "Scadding", "given": "Glenis", "initials": "G"}, {"family": "Senior", "given": "Brent", "initials": "B"}, {"family": "Smith", "given": "Pete", "initials": "P"}, {"family": "Y\u00e1\u00f1ez", "given": "Anah\u00ed", "initials": "A"}, {"family": "Zaitoun", "given": "Fares", "initials": "F"}, {"family": "Hellings", "given": "Peter W", "initials": "PW"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "World Allergy Organ J", "issn": "1939-4551", "volume": "15", "issue": "7", "pages": "100661", "issn-l": "1939-4551"}, "abstract": "Patient care in the allergy and respiratory fields is advancing rapidly, offering the possibility of the inclusion of a variety of digital tools that aim to improve outcomes of care. Impaired access to several health care facilities during the COVID-19 pandemic has considerably increased the appetite and need for the inclusion of e-health tools amongst end-users. Consequently, a multitude of different e-health tools have been launched worldwide with various registration and access options, and with a wide range of offered benefits. From the perspective of both patients and healthcare providers (HCPs), as well as from a legal and device-related perspective, several features are important for the acceptance, effectiveness,and long-term use of e-health tools. Patients and physicians have different needs and expectations of how digital tools might be of help in the care pathway. There is a need for standardization by defining quality assurance criteria. Therefore, the Upper Airway Diseases Committee of the World Allergy Organization (WAO) has taken the initiative to define and propose criteria for quality, appeal, and applicability of e-health tools in the allergy and respiratory care fields from a patient, clinician, and academic perspective with the ultimate aim to improve patient health and outcomes of care.", "doi": "10.1016/j.waojou.2022.100661", "pmid": "35784945", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1939-4551(22)00037-0"}, {"db": "pmc", "key": "PMC9243254"}], "notes": [], "created": "2022-08-17T13:10:51.707Z", "modified": "2022-08-17T13:10:51.720Z"}, {"entity": "publication", "iuid": "9cb40d5b1e9c472380fa0a51dd85c534", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9cb40d5b1e9c472380fa0a51dd85c534.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9cb40d5b1e9c472380fa0a51dd85c534"}}, "title": "Acute odynophagia: A new symptom of COVID-19 during the SARS-CoV-2 Omicron variant wave in Sweden.", "authors": [{"family": "Piersiala", "given": "Krzysztof", "initials": "K", "orcid": "0000-0003-3711-8371", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a8e2fbec7bb40ef8c1124526d3ac846.json"}}, {"family": "Kakabas", "given": "Lara", "initials": "L"}, {"family": "Bruckova", "given": "Anna", "initials": "A"}, {"family": "Starkhammar", "given": "Magnus", "initials": "M"}, {"family": "Cardell", "given": "Lars Olaf", "initials": "LO"}], "type": "case reports", "published": "2022-07-00", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": "292", "issue": "1", "pages": "154-161", "issn-l": null}, "abstract": "The objective of this study is to present a novel clinical manifestation of infection with the Omicron variant of the SARS-CoV-2 virus affecting mainly young, vaccinated, and healthy adults. We describe a new group of COVID-19 patients seeking emergency care with symptoms similar to the life-threatening condition epiglottitis. Here, we present a case series and discuss management.\n\nWe performed a retrospective single-center case study of patients diagnosed with COVID-19 who were referred to the Ear, Nose, and Throat Emergency Department (ENT ED) between January 1 and January 23, 2022 with clinical symptoms such as acute odynophagia, severe sore throat, and fever. Ethical approval was obtained from the Swedish Ethical Review Authority (2020-02579). Informed consent was obtained from all patients included in the study.\n\nTwenty patients meeting inclusion criteria were identified. Fifteen patients were fully vaccinated against COVID-19. Four patients needed a short hospitalization for their symptoms. The most common diagnoses were COVID-19-associated acute viral laryngotracheitis and/or viral pharyngitis. Six patients presented with signs of secondary bacterial infection and were put on antibiotics.\n\nPrevious variants of SARS-CoV-2 infection affected predominantly the lower respiratory tract and were associated with loss of smell and taste in many patients. The Omicron variant seems to affect predominantly the upper airways and cause acute laryngitis without olfactory dysfunction. In some patients, the clinical manifestation is similar to the symptoms of epiglottitis. In such a case, a prompt examination of the larynx is the gold standard to exclude inflammatory edema in the upper airways. None of the patients described in this study developed epiglottitis. In this study, we discuss the management of acute odynophagia in COVID-19 patients.", "doi": "10.1111/joim.13470", "pmid": "35170099", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Omicron VoC": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC9115132"}], "notes": [], "created": "2023-07-13T11:25:59.766Z", "modified": "2023-07-13T11:25:59.881Z"}, {"entity": "publication", "iuid": "b1afaead4b2549a896f087c73a1b5421", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1afaead4b2549a896f087c73a1b5421.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1afaead4b2549a896f087c73a1b5421"}}, "title": "A Qualitative Serial Analysis of Drawings by Thirteen-to Fifteen-Year-Old Adolescents in Sweden About the First Wave of the Covid-19 Pandemic.", "authors": [{"family": "Tishelman", "given": "Carol", "initials": "C", "orcid": "0000-0003-4161-0342", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1fbfdb57e5124e72bcffcce93b21fa05.json"}}, {"family": "Degen", "given": "Johanna L", "initials": "JL", "orcid": "0000-0002-0530-1385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c045049dcce40d8acc195b696cda010.json"}}, {"family": "Weiss Goitiand\u00eda", "given": "Sof\u00eda", "initials": "S", "orcid": "0000-0001-6538-0786", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5a80a546baf4241a238dd3850dbb9dc.json"}}, {"family": "Kleijberg", "given": "Max", "initials": "M", "orcid": "0000-0003-4036-707X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8087207bbaa34fdc896906ea11ada0fc.json"}}, {"family": "Kleeberg-Niepage", "given": "Andrea", "initials": "A", "orcid": "0000-0002-2433-8714", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fad2466bf73045b48d00493c9ea0ab4a.json"}}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Qual Health Res", "issn": "1049-7323", "pages": "1370-1385", "volume": "32", "issue": "8-9", "issn-l": null}, "abstract": "In this article, we explore the perspectives of 13-15-year-olds living in Sweden about the first wave of the Covid-19 pandemic, through inductive analysis of 187 of their drawings. Through reconstructive serial picture analysis, three types of meaning were derived: (1) A new normal in dystopian scenery points to the disruption of daily life and development of new praxis and meaning in a context of threat and restriction; (2) Disrupted relationships refers to these adolescents' self-portrayal as solitary, without adult guidance or friends prominent; and (3) Negative emotions and compliant behaviors addresses a range of negative emotions and expressions of loss with few proactive strategies illustrated. General existential distress appears in these drawings, seemingly compounded by both developmental stage and other factors in addition to the pandemic context. Drawings suggest a restricted repertoire of ways of dealing with challenges confronting these adolescents, who seemed to feel left to their own resources.", "doi": "10.1177/10497323221101978", "pmid": "35599585", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9350847"}], "notes": [], "created": "2022-06-21T17:58:05.053Z", "modified": "2023-01-13T14:48:28.475Z"}, {"entity": "publication", "iuid": "91af983740274e2e8242aa0949ed018e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/91af983740274e2e8242aa0949ed018e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/91af983740274e2e8242aa0949ed018e"}}, "title": "The Relationship between COVID-19 and Hypothalamic-Pituitary-Adrenal Axis: A Large Spectrum from Glucocorticoid Insufficiency to Excess-The CAPISCO International Expert Panel.", "authors": [{"family": "Jensterle", "given": "Mojca", "initials": "M", "orcid": "0000-0002-8861-8803", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59986ccac1b64e869ae0bd6761209852.json"}}, {"family": "Herman", "given": "Rok", "initials": "R", "orcid": "0000-0002-6053-5686", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff3ab4ee68944de5b693af679f9ca8df.json"}}, {"family": "Jane\u017e", "given": "Andrej", "initials": "A", "orcid": "0000-0002-6594-5254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43670b2197b8438e85feec7094864ce5.json"}}, {"family": "Mahmeed", "given": "Wael Al", "initials": "WA", "orcid": "0000-0003-0312-9910", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/263122e48a624950a78cfa8d0aca83bd.json"}}, {"family": "Al-Rasadi", "given": "Khalid", "initials": "K", "orcid": "0000-0003-0460-1236", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa65f0bc61f44c47860a15aa8b7eba15.json"}}, {"family": "Al-Alawi", "given": "Kamila", "initials": "K"}, {"family": "Banach", "given": "Maciej", "initials": "M"}, {"family": "Banerjee", "given": "Yajnavalka", "initials": "Y", "orcid": "0000-0002-7546-8893", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d8dea02972d4523816d940a6e0d2fb6.json"}}, {"family": "Ceriello", "given": "Antonio", "initials": "A"}, {"family": "Cesur", "given": "Mustafa", "initials": "M", "orcid": "0000-0002-1029-2604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b6591ae68a0442cfba8dbca9f28d9104.json"}}, {"family": "Cosentino", "given": "Francesco", "initials": "F"}, {"family": "Galia", "given": "Massimo", "initials": "M"}, {"family": "Goh", "given": "Su-Yen", "initials": "SY"}, {"family": "Kalra", "given": "Sanjay", "initials": "S"}, {"family": "Kempler", "given": "Peter", "initials": "P"}, {"family": "Lessan", "given": "Nader", "initials": "N", "orcid": "0000-0001-9147-0961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6fe7d1c124a4a349038f540cbf6721f.json"}}, {"family": "Lotufo", "given": "Paulo", "initials": "P"}, {"family": "Papanas", "given": "Nikolaos", "initials": "N", "orcid": "0000-0002-7320-785X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/540620683a4749568584a98e68dc73ed.json"}}, {"family": "Rizvi", "given": "Ali A", "initials": "AA", "orcid": "0000-0002-3714-0790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ab189188b8e4543aafa50f2422c70ea.json"}}, {"family": "Santos", "given": "Raul D", "initials": "RD"}, {"family": "Stoian", "given": "Anca P", "initials": "AP", "orcid": "0000-0003-0555-526X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0aef0cbf4cae4db68b4248baf9a8da4e.json"}}, {"family": "Toth", "given": "Peter P", "initials": "PP", "orcid": "0000-0001-5810-5460", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c17462263aef48dd8f61914bedb1a9a2.json"}}, {"family": "Viswanathan", "given": "Vijay", "initials": "V"}, {"family": "Rizzo", "given": "Manfredi", "initials": "M", "orcid": "0000-0002-9549-8504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d888593722ae4ba2b12a04effd67eaff.json"}}], "type": "journal article", "published": "2022-06-30", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "23", "issue": "13", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) is a highly heterogeneous disease regarding severity, vulnerability to infection due to comorbidities, and treatment approaches. The hypothalamic-pituitary-adrenal (HPA) axis has been identified as one of the most critical endocrine targets of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that might significantly impact outcomes after infection. Herein we review the rationale for glucocorticoid use in the setting of COVID-19 and emphasize the need to have a low index of suspicion for glucocorticoid-induced adrenal insufficiency, adjusting for the glucocorticoid formulation used, dose, treatment duration, and underlying health problems. We also address several additional mechanisms that may cause HPA axis dysfunction, including critical illness-related corticosteroid insufficiency, the direct cytopathic impacts of SARS-CoV-2 infection on the adrenals, pituitary, and hypothalamus, immune-mediated inflammations, small vessel vasculitis, microthrombotic events, the resistance of cortisol receptors, and impaired post-receptor signaling, as well as the dissociation of ACTH and cortisol regulation. We also discuss the increased risk of infection and more severe illness in COVID-19 patients with pre-existing disorders of the HPA axis, from insufficiency to excess. These insights into the complex regulation of the HPA axis reveal how well the body performs in its adaptive survival mechanism during a severe infection, such as SARS-CoV-2, and how many parameters might disbalance the outcomes of this adaptation.", "doi": "10.3390/ijms23137326", "pmid": "35806331", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijms23137326"}, {"db": "pmc", "key": "PMC9266848"}], "notes": [], "created": "2022-08-17T10:41:22.987Z", "modified": "2022-08-17T10:42:24.138Z"}, {"entity": "publication", "iuid": "01e843d52d084c7dbf5d8b9e20438faf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01e843d52d084c7dbf5d8b9e20438faf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01e843d52d084c7dbf5d8b9e20438faf"}}, "title": "Self-Assessed Aspects of Health 3 Months after COVID-19 Hospitalization-A Swedish Cross-Sectional Study.", "authors": [{"family": "Larsson", "given": "Alexandra C", "initials": "AC", "orcid": "0000-0001-9100-4071", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8532302825d744c7b29ccefeb16e11e2.json"}}, {"family": "Engwall", "given": "Marie", "initials": "M"}, {"family": "Palstam", "given": "Annie", "initials": "A", "orcid": "0000-0002-7127-213X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b127bce23f5545a5a17354e60b780f86.json"}}, {"family": "Persson", "given": "Hanna C", "initials": "HC", "orcid": "0000-0001-8633-3292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc8035c749ab4521b549ea820f6b4389.json"}}], "type": "journal article", "published": "2022-06-30", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "13", "issn-l": null}, "abstract": "It is not yet fully understood how the patients self-assess their overall health in the early recovery after COVID-19 and if certain patient groups are more prominent in perceived long-time effects of COVID-19. The aim of this study was to describe self-assessed aspects of health in body function, activity and participation 3 months after hospitalization due to COVID-19 and identify difference between groups depending in age, sex and level of hospital care. This cross-sectional study consists of self-assessed aspects of health and recovery in 168 participants (mean age 64 years old, 69% men) previously hospitalized patients due to COVID-19. We have previously published data, from hospital discharge, on this cohort were predominantly the older patients and previous ICU-treated participants were affected. In this study there were differences in between groups. Of the study population 72% perceived fatigue, 64% respiratory difficulties, 37% perceived symptoms of anxiety. Three-months after COVID-19 this cohort was overall still affected. The recovery process is multifaced and the cohort heterogeneous, hence the rehabilitation needs to be highly individualized, and the follow-up of this patient group is of importance regardless of age, sex and previous level of hospital care.", "doi": "10.3390/ijerph19138020", "pmid": "35805677", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19138020"}, {"db": "pmc", "key": "PMC9265939"}], "notes": [], "created": "2022-08-17T10:42:51.136Z", "modified": "2022-08-17T10:42:51.223Z"}, {"entity": "publication", "iuid": "4b1e5771831f45e5a86dff2c0d89c457", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b1e5771831f45e5a86dff2c0d89c457.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b1e5771831f45e5a86dff2c0d89c457"}}, "title": "Face mask-induced purpura: another unexpected effect of COVID era.", "authors": [{"family": "Piccolo", "given": "V", "initials": "V", "orcid": "0000-0001-7798-4368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1ddb3ce197e446dbc8156e8e3222d5e.json"}}, {"family": "Bassi", "given": "A", "initials": "A", "orcid": "0000-0002-9157-5189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2628d4790c0041b19e8bf037d259ed99.json"}}, {"family": "Mazzatenta", "given": "C", "initials": "C"}, {"family": "Russo", "given": "T", "initials": "T"}, {"family": "Argenziano", "given": "G", "initials": "G", "orcid": "0000-0003-1413-8214", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7fd2179bdb540a784d26cd05f39b77d.json"}}, {"family": "Cutrone", "given": "M", "initials": "M"}, {"family": "Danielsson Darlington", "given": "Markus Es", "initials": "ME"}, {"family": "Grimalt", "given": "R", "initials": "R", "orcid": "0000-0001-7204-8626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b47bbd772ef942cb87ee26fe24e0e0e7.json"}}], "type": "letter", "published": "2022-06-30", "journal": {"title": "J Eur Acad Dermatol Venereol", "issn": "1468-3083", "issn-l": null}, "abstract": null, "doi": "10.1111/jdv.18392", "pmid": "35771119", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9349894"}], "notes": [], "created": "2022-08-19T05:31:31.758Z", "modified": "2022-08-19T05:31:31.879Z"}, {"entity": "publication", "iuid": "5d844d0935554a7f8d3faadc2065998f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d844d0935554a7f8d3faadc2065998f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d844d0935554a7f8d3faadc2065998f"}}, "title": "Development of nurse-led videoconference-delivered cognitive behavioural therapy for domestic violence: Feasibility and acceptability.", "authors": [{"family": "Nesset", "given": "Merete Berg", "initials": "MB", "orcid": "0000-0003-4582-8349", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1fe1e4abc6f546ee8a1071eff3ae456f.json"}}, {"family": "Lauvrud", "given": "Christian", "initials": "C"}, {"family": "Meisingset", "given": "Anne", "initials": "A"}, {"family": "Nyhus", "given": "Eskil", "initials": "E"}, {"family": "Palmstierna", "given": "Tom", "initials": "T"}, {"family": "Lara-Cabrera", "given": "Mariela Loreto", "initials": "ML", "orcid": "0000-0002-7342-9049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bdee466c211435486b6f62b2940e473.json"}}], "type": "journal article", "published": "2022-06-30", "journal": {"title": "J Adv Nurs", "issn": "1365-2648", "issn-l": null}, "abstract": "Because of the COVID-19 lockdown, an internet-based adaption of a nurse-led cognitive behavioural group therapy (CGBT) was provided for perpetrators of domestic violence. The aim of this study was to describe the development of the therapy, examine the initial feasibility and impact on patient satisfaction of the programme and evaluate the associated patient-reported experiences.\n\nProgramme development as well as testing its feasibility and acceptability using cross-sectional survey data.\n\nAnonymous data were collected at a university hospital in Norway between October and December 2021. Feasibility was examined by comparing the numbers of patients who agreed to participate, chose not to participate or dropped out during the intervention. There was a self-reporting scale that evaluated patient satisfaction, and the participants were invited to make suggestions for improvement of the intervention. The results of the study are reported in accordance with the STROBE checklist.\n\nThe videoconference-delivered CGBT was feasible. Two of the 67 patients refused to attend therapy delivered in a remote manner (3.0%), and four patients (6.0%) were classified as non-completers. Overall, patients were satisfied with the therapy.\n\nThis study described a promising nurse-led internet-based intervention for individuals who were domestically violent and had voluntarily sought healthcare help. The participants' satisfaction with the intervention indicates its acceptability and feasibility. However, research on internet-based cognitive behaviour therapy is still in its infancy. These results may guide the future development of internet-based cognitive behavioural therapy (CBT) for individuals who perpetrate domestic violence. Further research is needed on the pros and cons of this mode of service delivery.\n\nThis study addressed the challenges of providing treatment for domestic violence during the COVID-19 pandemic by examining videoconference-delivered CBT for individuals who perpetrate domestic violence.", "doi": "10.1111/jan.15347", "pmid": "35774003", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-17T13:13:56.417Z", "modified": "2022-08-17T13:13:56.503Z"}, {"entity": "publication", "iuid": "23fd55e2b4e14e789737af66351eff51", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23fd55e2b4e14e789737af66351eff51.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23fd55e2b4e14e789737af66351eff51"}}, "title": "Development Work in Swedish Eldercare: Resources for Trustworthy, Integrated Managerial Work During the COVID-19 Pandemic.", "authors": [{"family": "Dellve", "given": "Lotta", "initials": "L"}, {"family": "Williamsson", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-06-30", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "10", "pages": "864272", "issn-l": "2296-2565"}, "abstract": "The extensive needs for developments of eldercare addressing working conditions, care quality, influence, and safety was highlighted during the pandemic. This mixed-method study contribute with knowledge about capability-strengthening development work and its importance for trustworthy managerial work, before and during the COVID-19 pandemic. Questionnaire data and narratives from first-line managers immediately before (n = 284) and 16 months into the pandemic (n = 189), structured interviews with development leaders (n = 25), and documents were analyzed. The results identify different focuses of development work. Strategic-level development leaders focused the strengthening of old adults' capabilities. While operational-level leaders approached strengthening employees' capability. First-line managers' rating of their trustworthy managerial work decreased during the pandemic and was associated with their workload, development support and capability-strengthening projects focusing employees' resources. The study demonstrates the gap between strategic and the operational levels regarding understanding of capability set and needed resources for strengthening capabilities and trustworthy, integrated managerial work regarding safety, influence, and quality conditions for old adults and employees.", "doi": "10.3389/fpubh.2022.864272", "pmid": "35844876", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9280882"}], "notes": [], "created": "2022-08-12T08:53:45.557Z", "modified": "2022-08-12T08:53:45.564Z"}, {"entity": "publication", "iuid": "c29c572267d64128b2d27af013aba852", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c29c572267d64128b2d27af013aba852.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c29c572267d64128b2d27af013aba852"}}, "title": "Mitochondrial dysfunction is associated with lipid metabolism disorder and upregulation of angiotensin-converting enzyme 2.", "authors": [{"family": "Zhao", "given": "Qian", "initials": "Q", "orcid": "0000-0001-9218-9506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd48776ed26440f9a727f785cbd98b38.json"}}, {"family": "Zhou", "given": "Xiaoshan", "initials": "X"}, {"family": "Kuiper", "given": "Raoul", "initials": "R"}, {"family": "Curbo", "given": "Sophie", "initials": "S"}, {"family": "Karlsson", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-06-29", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "6", "pages": "e0270418", "issn-l": "1932-6203"}, "abstract": "Thymidine kinase 2 (TK2) deficiency in humans leads to a myopathic form of mitochondrial DNA (mtDNA) deficiency. Here we present a skeletal and cardiac muscle specific TK2 knockout mouse (mTk2 KO). The mice showed dilated hearts and markedly reduced adipose tissue during week 12 to 16. A severe decrease of mtDNA was found only in skeletal muscle and heart tissue in mTk2 KO mice. Expression analysis of key metabolic genes of 16 weeks knockout mice showed significant changes of genes involved in lipid metabolism, with different patterns in heart and skeletal muscle. Our study further suggests that lipoprotein lipase (LPL) from liver supports the metabolism when heart and skeletal muscle were impaired due to mitochondrial dysfunction. The angiotensin-converting enzyme 2 (ACE2), which is involved in glucose homeostasis, was also affected by mtDNA deficiency in our study. Interestingly, both the gene and protein expression of ACE2 were increased in cardiac tissue of mTk2 KO mice. Since ACE2 is a receptor for the SARS-CoV-2 virus, its regulation in relation to mitochondrial function may have important clinical implications.", "doi": "10.1371/journal.pone.0270418", "pmid": "35767531", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-31565"}, {"db": "pmc", "key": "PMC9242481"}], "notes": [], "created": "2022-08-19T05:32:55.634Z", "modified": "2022-08-19T05:32:55.692Z"}, {"entity": "publication", "iuid": "c7ee9a93593848aea5b72f76cf9d6a2a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7ee9a93593848aea5b72f76cf9d6a2a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7ee9a93593848aea5b72f76cf9d6a2a"}}, "title": "Elementary School Teachers' Perceptions of COVID-19-Related Restrictions on Food Allergy Management.", "authors": [{"family": "Santos", "given": "Mae Jhelene L", "initials": "MJL"}, {"family": "Riediger", "given": "Natalie", "initials": "N", "orcid": "0000-0002-8736-9446", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc59a9c00b1b4d4cb2cbb391b115a789.json"}}, {"family": "Abrams", "given": "Elissa M", "initials": "EM"}, {"family": "Piquemal", "given": "Nathalie", "initials": "N"}, {"family": "Protudjer", "given": "Jennifer L P", "initials": "JLP", "orcid": "0000-0002-3888-8688", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e35d8fddae04acbb44382b43acb0147.json"}}], "type": "journal article", "published": "2022-06-29", "journal": {"title": "Nutrients", "issn": "2072-6643", "volume": "14", "issue": "13", "issn-l": null}, "abstract": "(1) Background: Approximately 7% of Canadian children live with a food allergy (FA). Pre-COVID-19, ~20% of anaphylactic reactions occurred in schools. Yet, teachers reported poor FA-related knowledge, and experiences during the COVID-19 pandemic are not well-studied. Additionally, teachers' management approaches vary widely. We aimed to describe elementary school teachers' perceptions about FA management during the COVID-19 pandemic; (2) Methods: Using a semi-structured interview guide, English-speaking elementary school teachers in Winnipeg, Canada were interviewed virtually. Interviews were audio-recorded and transcribed verbatim. Data were analysed thematically; (3) Results: Most teachers were female and taught in public schools. Two themes were identified. Theme 1, COVID-19 restrictions made mealtimes more manageable, capturing the positive impacts of pandemic restrictions such as seating arrangements and enhanced cleaning. Limited lunchtime supervision prompted some teachers to assume this role. Theme 2, Food allergy management was indirectly adapted to fit changing COVID-19 restrictions, describing how changing restrictions influenced FA-related practices. FA training was offered virtually with less nursing support. Class cohorts and remote learning decreased teachers' perceived risk and FA-related management responsibility; (4) Conclusions: COVID-19-related practices were perceived as positively influencing in-school FA management, although unintended consequences, such as increased supervisory roles for teachers and reduced nursing support, were described.", "doi": "10.3390/nu14132714", "pmid": "35807894", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "nu14132714"}, {"db": "pmc", "key": "PMC9268574"}], "notes": [], "created": "2022-08-17T10:41:54.202Z", "modified": "2022-08-17T10:42:02.391Z"}, {"entity": "publication", "iuid": "9bc47c462b2e4d38ad40b313692930b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9bc47c462b2e4d38ad40b313692930b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9bc47c462b2e4d38ad40b313692930b3"}}, "title": "Citizens' Use of eHealth Services During COVID-19 in Relation to National Policy Goals.", "authors": [{"family": "Koch", "given": "Sabine", "initials": "S"}, {"family": "Vimarlund", "given": "Vivian", "initials": "V"}], "type": "journal article", "published": "2022-06-29", "journal": {"title": "Stud Health Technol Inform", "issn": "1879-8365", "volume": "295", "pages": "12-15", "issn-l": null}, "abstract": "The main goals of the Swedish eHealth strategy are to enable citizens to achieve good and equal health and welfare, and to support self-determination and increased participation in society. We analyzed the relationship between these goals and the use of eHealth services offered for citizens prior to and during the COVID-19 pandemic. Data was collected through a national citizen survey issued in 2019 and 2021 to a sample size of 15.000 representative individuals each. Results showed that the use of eHealth services was highest in the 30-49 years age group and among respondents with high education. There were no major differences between respondents with high, medium, or low income, and neither between respondents with different degrees of self-perceived health, nor between native Swedish and non-Swedish respondents. Changes in use of different eHealth services over time were most probably related to the pandemic and are not significant. All age groups showed a similar relative increase regarding their use of eHealth services, except when searching the Internet for diagnosis and treatment where persons above 75 years of age had the largest increase. Most significant were the increase in online visits and the decrease in maintaining health, training, or food diaries. Strategic goals related to equity seem to be partly met as eHealth services are used to the same degree by different socio-economic groups. However, the older population uses eHealth services less than other age groups and a deeper understanding of the relationship between specific services and their impact on strategic goals is needed.", "doi": "10.3233/SHTI220647", "pmid": "35773793", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "SHTI220647"}], "notes": [], "created": "2022-08-17T13:14:11.436Z", "modified": "2022-08-17T13:14:11.466Z"}, {"entity": "publication", "iuid": "3a05f12e943b40df96ed49f68db01114", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a05f12e943b40df96ed49f68db01114.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a05f12e943b40df96ed49f68db01114"}}, "title": "Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2021.", "authors": [{"family": "Ikonomou", "given": "Laertis", "initials": "L"}, {"family": "Magnusson", "given": "Mattias", "initials": "M"}, {"family": "Dries", "given": "Ruben", "initials": "R"}, {"family": "Herzog", "given": "Erica L", "initials": "EL"}, {"family": "Hynds", "given": "Robert", "initials": "R"}, {"family": "Borok", "given": "Zea", "initials": "Z"}, {"family": "Park", "given": "Jin-Ah", "initials": "JA"}, {"family": "Skolasinski", "given": "Steven", "initials": "S"}, {"family": "Burgess", "given": "Janette K", "initials": "JK"}, {"family": "Turner", "given": "Leigh", "initials": "L"}, {"family": "Mojarad", "given": "Sarah M", "initials": "SM"}, {"family": "Mahoney", "given": "John E", "initials": "JE"}, {"family": "Lynch", "given": "Thomas", "initials": "T"}, {"family": "Lehmann", "given": "Mareike", "initials": "M"}, {"family": "Thannickal", "given": "Victor J", "initials": "VJ"}, {"family": "Hook", "given": "Jaime L", "initials": "JL"}, {"family": "Vaughan", "given": "Andrew E", "initials": "AE"}, {"family": "Hoffman", "given": "Evan T", "initials": "ET"}, {"family": "Weiss", "given": "Daniel J", "initials": "DJ"}, {"family": "Ryan", "given": "Amy L", "initials": "AL"}], "type": "journal article", "published": "2022-06-28", "journal": {"title": "Am J Physiol Lung Cell Mol Physiol", "issn": "1522-1504", "issn-l": null}, "abstract": "The 9th biennial conference titled \"Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases\" was hosted virtually, due to the ongoing COVID-19 pandemic, in collaboration with the University of Vermont Larner College of Medicine, the National Heart, Lung, and Blood Institute, the Alpha-1 Foundation, the Cystic Fibrosis Foundation, and the International Society for Cell & Gene Therapy. The event was held from July 12th through 15th, 2021 with a pre-conference workshop held July 9th. As in previous years the objectives remained to review and discuss the status of active research areas involving stem cells, cellular therapeutics, and bioengineering as they relate to the human lung. Topics included: 1) technological advancements in the in situ analysis of lung tissues, 2) new insights into stem cell signalling and plasticity in lung remodelling and regeneration, 3) the impact of extracellular matrix in stem cell regulation and airway engineering in lung regeneration, 4) differentiating and delivering stem cell therapeutics to the lung, 5) regeneration in response to viral infection, and 6) ethical development of cell-based treatments for lung diseases. This selection of topics represents some of the most dynamic and current research areas in lung biology. The virtual workshop included active discussion on state-of-the-art methods relating to the core features of the 2021 conference, including in-situ protemics, lung-on-chip, iPSC-airway differentiation, and light sheet microscopy. The conference concluded with an open discussion to suggest funding priorities and recommendations for future research directions in basic and translational lung biology.", "doi": "10.1152/ajplung.00113.2022", "pmid": "35762622", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-19T05:35:18.537Z", "modified": "2022-08-19T05:35:18.575Z"}, {"entity": "publication", "iuid": "d24b783fef17424e98d1271acb367c5b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d24b783fef17424e98d1271acb367c5b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d24b783fef17424e98d1271acb367c5b"}}, "title": "Low Prevalence of Mild Alpha-1-Antitrypsin Deficiency in Hospitalized COVID-19-Patients.", "authors": [{"family": "Nygren", "given": "David", "initials": "D", "orcid": "0000-0003-2426-7204", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d84ae6e240ec4a3caaf519a43f9d7cf9.json"}}, {"family": "M\u00f6lstad", "given": "Ulrica", "initials": "U"}, {"family": "Thulesius", "given": "Hans", "initials": "H", "orcid": "0000-0002-3785-5630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f7d45ab8dd94b89873fb2e44a0a8770.json"}}, {"family": "Hillman", "given": "Magnus", "initials": "M"}, {"family": "Broman", "given": "Lars Mikael", "initials": "LM", "orcid": "0000-0003-4124-4581", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6792bc7f2ba4afe931144a4a8a6bca9.json"}}, {"family": "Tanash", "given": "Hanan", "initials": "H"}, {"family": "Landin-Olsson", "given": "Mona", "initials": "M"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}, {"family": "Thunander", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2022-06-28", "journal": {"title": "Int J Gen Med", "issn": "1178-7074", "volume": "15", "pages": "5843-5848", "issn-l": null}, "abstract": "Alpha-1-antitrypsin (AAT) has been shown to inhibit SARS-CoV-2 cell entry and suggested as a therapeutic agent for COVID-19. Furthermore, epidemiological association of high prevalence of Alpha-1-antitrypsin deficiency (AATD) and regional severity of COVID-19-impact has been hypothesized. In our study setting, the estimated prevalence rates of mild (PI*MZ, PI*SS or PI*MS) and moderate-to-severe AATD (PI*ZZ or PI*SZ) are high, 9% and 0.2%, respectively. Our primary aim was to examine the prevalence rate of AATD among hospitalized COVID-19-patients.\n\nIn this prospective observational study, enrollment occurred from December 2020 to January 2021 in two COVID-19-units at Sk\u00e5ne University Hospital, Lund, Sweden. Case definition was a patient hospitalized due to COVID-19. Patients were screened for AATD with PI-typing and if results were inconclusive, PCR for the S- and Z-genes were performed. Patients were categorized as severe or moderate COVID-19 and 30-day-mortality data were collected. The primary outcome was prevalence rate of AATD. The secondary outcome investigated association between presence of mild AATD and severe COVID-19.\n\nWe enrolled 61 patients with COVID-19. Two patients out of 61 (3%) had mild AATD (PI*MZ) and none had moderate-to-severe AATD. 30/61 (49%) had severe COVID-19. Both patients with mild AATD developed severe COVID-19. Yet, presence of AATD was not significantly associated with severe COVID-19 (p=0.24).\n\nMild AATD (PI*MS or PI*MZ) was rare in a small cohort of hospitalized patients with COVID-19 in a study setting with a high background prevalence of AATD.", "doi": "10.2147/IJGM.S370434", "pmid": "35789772", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "370434"}, {"db": "pmc", "key": "PMC9250346"}], "notes": [], "created": "2022-08-17T13:08:54.738Z", "modified": "2022-08-17T13:08:54.844Z"}, {"entity": "publication", "iuid": "59dd4a10ac14474cab50fcc41b94cc76", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/59dd4a10ac14474cab50fcc41b94cc76.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/59dd4a10ac14474cab50fcc41b94cc76"}}, "title": "Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records.", "authors": [{"family": "Thompson", "given": "Ellen J", "initials": "EJ", "orcid": "0000-0003-2118-821X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6754739394b24a5c8f5db22905b22c3c.json"}}, {"family": "Williams", "given": "Dylan M", "initials": "DM", "orcid": "0000-0002-3825-2487", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8be5ce9d68b4fcb870f1dce11ccdaef.json"}}, {"family": "Walker", "given": "Alex J", "initials": "AJ", "orcid": "0000-0003-4932-6135", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/392cc8f956754fabbf68946bf8a3581a.json"}}, {"family": "Mitchell", "given": "Ruth E", "initials": "RE", "orcid": "0000-0002-3506-160X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cbf4d3aa699e4af69037e7539fb4497a.json"}}, {"family": "Niedzwiedz", "given": "Claire L", "initials": "CL", "orcid": "0000-0001-6133-4168", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9cf7719d211648ab98b572b231354e15.json"}}, {"family": "Yang", "given": "Tiffany C", "initials": "TC"}, {"family": "Huggins", "given": "Charlotte F", "initials": "CF"}, {"family": "Kwong", "given": "Alex S F", "initials": "ASF", "orcid": "0000-0003-1953-2771", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65ccb94351224dbdbcaa53d6ef6502ba.json"}}, {"family": "Silverwood", "given": "Richard J", "initials": "RJ", "orcid": "0000-0002-2744-1194", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d46ad9468444d3dbfbe8f392b9fb502.json"}}, {"family": "Di Gessa", "given": "Giorgio", "initials": "G", "orcid": "0000-0001-6154-1845", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c2319c222cc40069a5f55ead6d361f6.json"}}, {"family": "Bowyer", "given": "Ruth C E", "initials": "RCE", "orcid": "0000-0002-6941-8160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eebaf361c184499ca6729aa60cc0af3d.json"}}, {"family": "Northstone", "given": "Kate", "initials": "K"}, {"family": "Hou", "given": "Bo", "initials": "B"}, {"family": "Green", "given": "Michael J", "initials": "MJ", "orcid": "0000-0003-3193-2452", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84efba4af3264153b510906d0f4dcb35.json"}}, {"family": "Dodgeon", "given": "Brian", "initials": "B"}, {"family": "Doores", "given": "Katie J", "initials": "KJ", "orcid": "0000-0002-5507-1725", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d626ec20fb5d424e97a63b876f8cc5f5.json"}}, {"family": "Duncan", "given": "Emma L", "initials": "EL", "orcid": "0000-0002-8143-4403", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26eb842103da464986b66de7d7751548.json"}}, {"family": "Williams", "given": "Frances M K", "initials": "FMK", "orcid": "0000-0002-2998-2744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87a6db988c2e421f81fce7773436aefa.json"}}, {"family": "OpenSAFELY Collaborative", "given": "", "initials": ""}, {"family": "Steptoe", "given": "Andrew", "initials": "A", "orcid": "0000-0001-7808-4943", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/532fa7059d1941df934fb7c759a76057.json"}}, {"family": "Porteous", "given": "David J", "initials": "DJ", "orcid": "0000-0003-1249-6106", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8575eb112a94584aa4fc08ebf3b49b7.json"}}, {"family": "McEachan", "given": "Rosemary R C", "initials": "RRC"}, {"family": "Tomlinson", "given": "Laurie", "initials": "L", "orcid": "0000-0001-8848-9493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03f2034f701e46f3919a944d2ac325d7.json"}}, {"family": "Goldacre", "given": "Ben", "initials": "B"}, {"family": "Patalay", "given": "Praveetha", "initials": "P"}, {"family": "Ploubidis", "given": "George B", "initials": "GB"}, {"family": "Katikireddi", "given": "Srinivasa Vittal", "initials": "SV", "orcid": "0000-0001-6593-9092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9bcdfb6c28e742878e7df8ee66fa6863.json"}}, {"family": "Tilling", "given": "Kate", "initials": "K", "orcid": "0000-0002-1010-8926", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b5bd223d89f4d5cbfbf5decf107d5b9.json"}}, {"family": "Rentsch", "given": "Christopher T", "initials": "CT", "orcid": "0000-0002-1408-7907", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32d3afaa4b844ddb9ecc43e313b877ab.json"}}, {"family": "Timpson", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0002-7141-9189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90b26df69dcd46bd9f6e4eebbf46a36f.json"}}, {"family": "Chaturvedi", "given": "Nishi", "initials": "N", "orcid": "0000-0002-6211-2775", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94889a94593342f688fc89e9419ef7d0.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}], "type": "journal article", "published": "2022-06-28", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "3528", "issn-l": "2041-1723"}, "abstract": "The frequency of, and risk factors for, long COVID are unclear among community-based individuals with a history of COVID-19. To elucidate the burden and possible causes of long COVID in the community, we coordinated analyses of survey data from 6907 individuals with self-reported COVID-19 from 10 UK longitudinal study (LS) samples and 1.1 million individuals with COVID-19 diagnostic codes in electronic healthcare records (EHR) collected by spring 2021. Proportions of presumed COVID-19 cases in LS reporting any symptoms for 12+ weeks ranged from 7.8% and 17% (with 1.2 to 4.8% reporting debilitating symptoms). Increasing age, female sex, white ethnicity, poor pre-pandemic general and mental health, overweight/obesity, and asthma were associated with prolonged symptoms in both LS and EHR data, but findings for other factors, such as cardio-metabolic parameters, were inconclusive.", "doi": "10.1038/s41467-022-30836-0", "pmid": "35764621", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-022-30836-0"}, {"db": "pmc", "key": "PMC9240035"}], "notes": [], "created": "2022-08-19T05:34:48.695Z", "modified": "2022-08-19T05:34:49.333Z"}, {"entity": "publication", "iuid": "1a8957a53d6c4e6fb319f4649104f201", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1a8957a53d6c4e6fb319f4649104f201.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1a8957a53d6c4e6fb319f4649104f201"}}, "title": "Knowledge, Attitude, and Perception of Cancer Patients towards COVID-19 in Pakistan: A Cross-Sectional Study.", "authors": [{"family": "Khattak", "given": "Saadullah", "initials": "S", "orcid": "0000-0001-6798-2991", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/619a53d915304bab9bde893f36292393.json"}}, {"family": "Faheem", "given": "Muhammad", "initials": "M"}, {"family": "Nawaz", "given": "Bilawal", "initials": "B"}, {"family": "Khan", "given": "Maqbool", "initials": "M", "orcid": "0000-0001-7656-0184", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6328703e91874423a0344d277cdf4159.json"}}, {"family": "Khan", "given": "Nazeer Hussain", "initials": "NH", "orcid": "0000-0003-4380-233X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/965d14c87f584cefa64f774f34d0f711.json"}}, {"family": "Ullah", "given": "Nadeem", "initials": "N", "orcid": "0000-0001-6089-8906", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69e0776f1bec447ab4b94b7277ceb178.json"}}, {"family": "Khan", "given": "Taj Ali", "initials": "TA"}, {"family": "Khan", "given": "Rahat Ullah", "initials": "RU", "orcid": "0000-0002-7109-6201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ba9d38e92be45a18c3a95c9fc82fc93.json"}}, {"family": "Haleem", "given": "Kashif Syed", "initials": "KS"}, {"family": "Ren", "given": "Zhi-Guang", "initials": "ZG"}, {"family": "Wu", "given": "Dong-Dong", "initials": "DD"}, {"family": "Ji", "given": "Xin-Ying", "initials": "XY"}], "type": "journal article", "published": "2022-06-28", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "13", "issn-l": null}, "abstract": "Cancer patients, being immunocompromised, are at higher risk of coronavirus disease (COVID-19). The current study determines cancer patients' knowledge, attitude, perception, and impact of the COVID-19 pandemic.\n\nA cross-sectional online survey was conducted in Pakistan from 1 April 2020 to 1 May 2020. The study respondents were cancer patients with ages equal to or greater than 18 years. Following a request for participation, the URL for the survey was distributed on numerous channels. Other social media platforms, including WeChat, WhatsApp, Facebook, Twitter, Instagram, Messenger, and LinkedIn, were used to increase cancer patient interaction. The questionnaire comprised five different sections such as: (1) sociodemographic information, (2) knowledge, (3) attitude, (4) perception, and (5) impact of COVID-19 on cancer patients. Descriptive medical statistics such as frequency, percentage, mean, and standard deviation were used to illustrate the demographic characteristics of the study participants. To compare mean knowledge scores with selected demographic variables, independent sample t-tests and one-way analysis of variance (ANOVA) were used, which are also practical methods in epidemiological, public health and medical research. The cut-off point for statistical significance was set at a p-value of 0.05.\n\nMore than 300 cancer patients were invited, of which 208 agreed to take part. The response rate was 69.33% (208/300). Gender, marital status, and employment status had a significant association with knowledge scores. Of the total recruited participants, 96% (n = 200) (p &lt; 0.01) knew about COVID-19, and 90% were aware of general symptoms of COVID-19 disease, such as route of transmission and preventive measurements. In total, 94.5% (n = 197) (p &lt; 0.01) were willing to accept isolation if they were infected with COVID-19, and 98% (n = 204) (p &lt; 0.01) had reduced their use of public transportation. More than 90% (n = 188) (p &lt; 0.01) of cancer patients were found to be practicing preventative measures such as using a face mask, keeping social distance, and avoiding handshaking and hugging. Around 94.4% (n = 196) (p &lt; 0.01) of cancer patients had been impacted by, stopped or had changed cancer treatment during this pandemic, resulting in COVID-related anxiety and depression.\n\nThe included cancer patients exhibited a good level of COVID-19 knowledge, awareness, positive attitude, and perception. Large-scale studies and efforts are needed to raise COVID-19 awareness among less educated and high-risk populations. The present survey indicates that mass-level effective health education initiatives are required for developing countries to improve and reduce the gap between KAP and COVID-19.", "doi": "10.3390/ijerph19137926", "pmid": "35805584", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19137926"}, {"db": "pmc", "key": "PMC9265320"}], "notes": [], "created": "2022-08-17T10:43:25.603Z", "modified": "2022-08-17T10:43:25.804Z"}, {"entity": "publication", "iuid": "7dff34c69089449393aa9f3d89b939a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7dff34c69089449393aa9f3d89b939a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7dff34c69089449393aa9f3d89b939a2"}}, "title": "Case Report: Post-Partum SARS-CoV-2 Infection After the First French Uterus Transplantation.", "authors": [{"family": "Ayoubi", "given": "Jean Marc", "initials": "JM"}, {"family": "Carbonnel", "given": "Marie", "initials": "M"}, {"family": "Kvarnstr\u00f6m", "given": "Niclas", "initials": "N"}, {"family": "Revaux", "given": "Aurelie", "initials": "A"}, {"family": "Poulain", "given": "Marine", "initials": "M"}, {"family": "Vanlieferinghen", "given": "Sarah", "initials": "S"}, {"family": "Coatantiec", "given": "Yves", "initials": "Y"}, {"family": "Le Marchand", "given": "Mathilde", "initials": "M"}, {"family": "Tourne", "given": "Morgan", "initials": "M"}, {"family": "Pirtea", "given": "Paul", "initials": "P"}, {"family": "Snanoudj", "given": "Renaud", "initials": "R"}, {"family": "Le Guen", "given": "Morgan", "initials": "M"}, {"family": "Dahm-K\u00e4hler", "given": "Pernilla", "initials": "P"}, {"family": "Racowsky", "given": "Catherine", "initials": "C"}, {"family": "Br\u00e4nnstr\u00f6m", "given": "Mats", "initials": "M"}], "type": "case reports", "published": "2022-06-28", "journal": {"title": "Front Surg", "issn": "2296-875X", "volume": "9", "pages": "854225", "issn-l": null}, "abstract": "Absolute uterus factor infertility, whether congenital or acquired, renders the woman unable to carry a child. Although uterus transplantation (UTx) is being increasingly performed as a non-vital procedure to address this unfortunate condition, the immunosuppression required presents risks that are further compounded by pregnancy and during the puerperium period. These vulnerabilities require avoidance of SARS-CoV-2 infection in pregnant UTx recipients especially during the third trimester, as accumulating evidence reveals increased risks of morbidity and mortality. Here we describe a successful UTx case with delivery of a healthy child, but in which both mother and neonate developed asymptomatic SARS-CoV-2 infection seven days after RNA vaccination, on day 35 post-partum. Although the patient was successfully treated with a combination therapy comprised of two monoclonal antibodies, this case highlights the challenges associated with performing UTx in the era of Covid-19. More broadly, the risks of performing non-vital organ transplantation during a pandemic should be discussed among team members and prospective patients, weighing the risks against the benefits in improving the quality of life, which were considerable for our patient who achieved motherhood with the birth of a healthy child.", "doi": "10.3389/fsurg.2022.854225", "pmid": "35836605", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9273879"}], "notes": [], "created": "2022-08-12T08:59:34.409Z", "modified": "2022-08-12T08:59:34.435Z"}, {"entity": "publication", "iuid": "93005bbd70ac43e2aad57a176dd155c8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/93005bbd70ac43e2aad57a176dd155c8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/93005bbd70ac43e2aad57a176dd155c8"}}, "title": "Adapting teaching and learning in times of COVID-19: a comparative assessment among higher education institutions in a global health network in 2020.", "authors": [{"family": "Puradiredja", "given": "Dewi Ismajani", "initials": "DI"}, {"family": "Kintu-Sempa", "given": "Linda", "initials": "L"}, {"family": "Eyber", "given": "Carola", "initials": "C"}, {"family": "Weigel", "given": "Ralf", "initials": "R"}, {"family": "Broucker", "given": "Bruno", "initials": "B"}, {"family": "Lindkvist", "given": "Marie", "initials": "M"}, {"family": "Casamitjana", "given": "Nuria", "initials": "N"}, {"family": "Reynolds", "given": "Rodney", "initials": "R"}, {"family": "Klinkel", "given": "Hans-Friedemann", "initials": "H"}, {"family": "Matteelli", "given": "Alberto", "initials": "A"}, {"family": "Froeschl", "given": "Guenter", "initials": "G"}], "type": "journal article", "published": "2022-06-28", "journal": {"title": "BMC Med Educ", "issn": "1472-6920", "issn-l": null, "volume": "22", "issue": "1", "pages": "507"}, "abstract": "This research examines the ways in which higher education institutions (HEIs) across the tropEd Network for Education in International Health (tropEd) began to adapt their teaching and learning approaches in response to the COVID-19 pandemic in 2020. Already during this early phase of the pandemic HEIs' responses demonstrate global health approaches emphasising cooperation and communication, rather than national health driven strategies that emphasise quarantine and control. Key lessons learnt for multiple dimensions of teaching and learning in global health are thus identified, and challenges and opportunities discussed.\r\n\r\nData collection includes a cross-sectional online survey among tropEd member institutions (n = 19) in mid-2020, and a complementary set of open-ended questions generating free-text responses (n = 9). Quantitative data were analysed using descriptive statistics, textual data were analysed using a Framework Analysis approach.\r\n\r\nWhile early on in the pandemic the focus was on a quick emergency switch to online teaching formats to ensure short-term continuity, and developing the administrative and didactic competence and confidence in digital teaching, there is already recognition among HEIs of the necessity for more fundamental quality and longer-term reforms in higher education in global health. Alongside practical concerns about the limitations of digital teaching, and declines in student numbers, there is a growing awareness of opportunities in terms of inclusivity, the necessity of cross-border cooperation, and a global health approach. The extent to which the lack of physical mobility impacts HEI programmes in global health is debated.\r\n\r\nThe COVID-19 pandemic has brought about preventive measures that have had a considerable impact on various dimensions of academic teaching in global health. Going forward, international HEIs' experiences and response strategies can help generate important lessons for academic institutions across different settings worldwide.", "doi": "10.1186/s12909-022-03568-4", "pmid": "35764985", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12909-022-03568-4"}, {"db": "pmc", "key": "PMC9238047"}], "notes": [], "created": "2022-08-19T05:33:24.334Z", "modified": "2022-11-09T08:38:50.944Z"}, {"entity": "publication", "iuid": "19d3b486739b4d6f8691c56b2afa7a74", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19d3b486739b4d6f8691c56b2afa7a74.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19d3b486739b4d6f8691c56b2afa7a74"}}, "title": "Sensitization symptoms are associated with psychological and cognitive variables in COVID-19 survivors exhibiting post-COVID pain.", "authors": [{"family": "Fern\u00e1ndez-de-Las-Pe\u00f1as", "given": "C\u00e9sar", "initials": "C"}, {"family": "Par\u00e1s-Bravo", "given": "Paula", "initials": "P"}, {"family": "Ferrer-Pargada", "given": "Diego", "initials": "D", "orcid": "0000-0001-9088-5946", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a035c7a4f73a4ffd95b2f99695fdc2b0.json"}}, {"family": "Cancela-Cilleruelo", "given": "Ignacio", "initials": "I"}, {"family": "Rodr\u00edguez-Jim\u00e9nez", "given": "Jorge", "initials": "J"}, {"family": "Nijs", "given": "Jo", "initials": "J"}, {"family": "Arendt-Nielsen", "given": "Lars", "initials": "L"}, {"family": "Herrero-Montes", "given": "Manuel", "initials": "M", "orcid": "0000-0002-5732-8344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3460d36201934582b42366a9e2e736c0.json"}}], "type": "journal article", "published": "2022-06-27", "journal": {"title": "Pain Pract", "issn": "1533-2500", "issn-l": null}, "abstract": "To investigate the association between demographic, clinical, psychological, cognitive, and health-related variables and the Central Sensitization Inventory (CSI) in previously hospitalized COVID-19 survivors exhibiting \"de novo\" post-COVID pain.\n\nSeventy-seven (n = 77) COVID-19 survivors with \"de novo\" post-COVID pain completed demographic (age, height, and weight), clinical (duration and intensity of the pain), psychological (depressive/anxiety levels and sleep quality), cognitive (catastrophizing and kinesiophobia levels), and health-related quality of life variables as well as the CSI. A multivariable correlation analysis was conducted to determine the association between variables, and a stepwise multiple linear regression model was performed to identify CSI predictors.\n\nPatients were assessed a mean of 6.0 (SD 0.8) months after hospital discharge. Twenty-six (33.7%) individuals showed indications of sensitization-associated symptoms (CSI score \u226540 points). The CSI score was positively associated with pain intensity (r: 0.371), anxiety (r: 0.784), depressive (r: 0.709), catastrophizing (r: 0.620), and kinesiophobia (r: 0.359) levels (all, p < 0.001). The stepwise regression analysis revealed that 60.2% of CSI was explained by anxiety levels and pain intensity.\n\nThis study found that psychological and cognitive variables were associated with the CSI score in previously hospitalized COVID-19 survivors with \"de novo\" post-COVID pain. Anxiety levels and the intensity of pain symptoms were independently associated with CSI score suggesting a significant overlap with psychological construct. The \"de novo\" post-COVID pain association with CSI may indicate changes in the pain processing important for managing the pain.", "doi": "10.1111/papr.13146", "pmid": "35757896", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9350126"}], "notes": [], "created": "2022-08-19T05:37:46.172Z", "modified": "2022-08-19T05:37:46.280Z"}, {"entity": "publication", "iuid": "93c3450a3c054009a215c5c1b16e807e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/93c3450a3c054009a215c5c1b16e807e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/93c3450a3c054009a215c5c1b16e807e"}}, "title": "Associations between fear of COVID-19, dental anxiety, and psychological distress among Iranian adolescents.", "authors": [{"family": "Tofangchiha", "given": "Maryam", "initials": "M"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Scheerman", "given": "Janneke F M", "initials": "JFM"}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Ahonen", "given": "Hanna", "initials": "H"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Tadakamadla", "given": "Santosh Kumar", "initials": "SK"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2022-06-27", "journal": {"title": "BDJ Open", "issn": "2056-807X", "volume": "8", "issue": "1", "pages": "19", "issn-l": null}, "abstract": "The present study evaluated the association of fear of COVID-19 with dental anxiety, oral health-related quality of life (OHRQoL), and psychological distress (depression, anxiety and stress), as well as exploring the mediating role of dental anxiety in the association of fear of COVID-19 with OHRQoL and psychological distress.\n\nA cross-sectional study was conducted among adolescents in high schools of Qazvin city (Iran) from March-June 2021, recruited through a two-stage cluster sampling method. All the adolescents completed a self-administered survey assessing (i) fear of COVID-19, (ii) depression, anxiety and stress, (iii) OHRQoL, and (iv) dental anxiety. Structural equation modelling was used to evaluate all the hypothesised associations, and the model fit was estimated.\n\nA total of 2429 adolescents participated in the study. The conceptual model fitted the data well. Fear of COVID-19 had a direct effect on dental anxiety (B = 0.316; bias-corrected bootstrapping 95% CI = 0.282, 0.349), depression (B = 0.302; bias-corrected bootstrapping 95% CI = 0.259, 0.347), anxiety (B = 0.289; bias-corrected bootstrapping 95% CI = 0.246, 0.334), stress (B = 0.282; bias-corrected bootstrapping 95% CI = 0.237, 0.328), and OHRQoL (B = -0.354; bias-corrected bootstrapping 95% CI = -0.530, -0.183). Also, dental anxiety mediated the association of fear of COVID-19 with depression, anxiety stress, and OHRQoL.\n\nHigh levels of fear of COVID-19 were associated with high levels of dental anxiety and poorer OHRQoL. Moreover, fear of COVID-19 was positively associated with anxiety, depression and stress. Increased levels of dental anxiety were also associated with increased anxiety, stress, depression, and poorer OHRQoL.", "doi": "10.1038/s41405-022-00112-w", "pmid": "35760784", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41405-022-00112-w"}, {"db": "pmc", "key": "PMC9237055"}], "notes": [], "created": "2022-08-19T05:36:56.517Z", "modified": "2022-08-19T05:36:56.590Z"}, {"entity": "publication", "iuid": "e9703db559424cb8bf03af9e914f4275", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e9703db559424cb8bf03af9e914f4275.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e9703db559424cb8bf03af9e914f4275"}}, "title": "A comparative analysis of experienced uncertainties in relation to risk communication during COVID19: a four-country study.", "authors": [{"family": "Cristea", "given": "Florin", "initials": "F"}, {"family": "Weishaar", "given": "Heide", "initials": "H"}, {"family": "Geurts", "given": "Brogan", "initials": "B"}, {"family": "Delamou", "given": "Alexandre", "initials": "A"}, {"family": "Tan", "given": "Melisa Mei Jin", "initials": "MMJ"}, {"family": "Legido-Quigley", "given": "Helena", "initials": "H"}, {"family": "Aminu", "given": "Kafayat", "initials": "K"}, {"family": "Mari-S\u00e1ez", "given": "Almudena", "initials": "A"}, {"family": "Rocha", "given": "Carlos", "initials": "C"}, {"family": "Camara", "given": "Bienvenu", "initials": "B"}, {"family": "Barry", "given": "Lansana", "initials": "L"}, {"family": "Thea", "given": "Paul", "initials": "P"}, {"family": "Boucsein", "given": "Johannes", "initials": "J"}, {"family": "Bahr", "given": "Thurid", "initials": "T"}, {"family": "Al-Awlaqi", "given": "Sameh", "initials": "S"}, {"family": "Pozo-Martin", "given": "Francisco", "initials": "F"}, {"family": "Boklage", "given": "Evgeniya", "initials": "E"}, {"family": "Jegede", "given": "Ayodele Samuel", "initials": "AS"}, {"family": "Bcheraoui", "given": "Charbel El", "initials": "CE"}], "type": "journal article", "published": "2022-06-27", "journal": {"title": "Global Health", "issn": "1744-8603", "volume": "18", "issue": "1", "pages": "66", "issn-l": "1744-8603"}, "abstract": "During outbreaks, uncertainties experienced by affected communities can influence their compliance to government guidance on public health. Communicators and authorities are, hence, encouraged to acknowledge and address such uncertainties. However, in the midst of public health crises, it can become difficult to define and identify uncertainties that are most relevant to address. We analyzed data on COVID-19-related uncertainties from four socio-economic contexts to explore how uncertainties can influence people's perception of, and response to Risk Communication and Community Engagement (RCCE) strategies.\n\nThis qualitative study, which adopts an interpretative approach, is based on data from a documentary review, key informant interviews (KII), and focus group discussions (FGD) with members of the general public and people with barriers to information from Germany, Guinea, Nigeria, and Singapore. Transcripts from the KII and FGD were coded and analyzed thematically. We interviewed a total of 155 KIs and conducted 73 FGD. Our analysis uncovered a divergence between uncertainties deemed relevant by stakeholders involved in policy making and uncertainties that people reportedly had to navigate in their everyday lives and which they considered relevant during the pandemic. We identified four types of uncertainties that seemed to have influenced people's assessment of the disease risk and their trust in the pandemic control strategies including RCCE efforts: epidemiological uncertainties (related to the nature and severity of the virus), information uncertainties (related to access to reliable information), social uncertainties (related to social behavior in times of heightened risk), and economic uncertainties (related to financial insecurities).\n\nWe suggest that in future outbreaks, communicators and policy makers could improve the way in which affected communities assess their risk, and increase the trust of these communities in response efforts by addressing non-epidemiological uncertainties in RCCE strategies.", "doi": "10.1186/s12992-022-00857-x", "pmid": "35761365", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12992-022-00857-x"}, {"db": "pmc", "key": "PMC9235152"}], "notes": [], "created": "2022-08-19T05:35:54.224Z", "modified": "2022-08-19T05:35:54.240Z"}, {"entity": "publication", "iuid": "5913952e0d3b4443bcace68980cf43ed", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5913952e0d3b4443bcace68980cf43ed.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5913952e0d3b4443bcace68980cf43ed"}}, "title": "Socio-Ecological Factors and Well-Being among Self-Employed in Europe during the COVID-19 Pandemic.", "authors": [{"family": "Hansson", "given": "Josefine", "initials": "J", "orcid": "0000-0001-6385-1556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04f28c63354f4e11b27b8abdab4c58b7.json"}}, {"family": "Nordenmark", "given": "Mikael", "initials": "M"}, {"family": "Tjulin", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Landstad", "given": "Bodil J", "initials": "BJ"}, {"family": "Vinberg", "given": "Stig", "initials": "S", "orcid": "0000-0002-5935-5688", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c63c4ca58d242d18741dba0b0af5afb.json"}}], "type": "journal article", "published": "2022-06-26", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "13", "issn-l": null}, "abstract": "The self-employed are at increased risk of negative well-being outcomes when facing adversity such as the COVID-19 pandemic. Studies that examine socio-ecological factors that may protect their well-being are warranted.\n\nData were drawn from a cross-sectional survey of European self-employed people (n = 1665). The WHO-5 Well-being Index was used to examine the impact on well-being of factors at four socio-ecological levels. Independent sample t-tests, Pearson correlations and linear regression were applied to analyse differences between groups of self-employed and interactions between variables using SPSS.\n\nWell-being and the socio-ecological factors of resilience, social support, useful work and finding the rules clear were positively correlated with well-being. For self-employed who reported that it was challenging to run their business during the pandemic, social support and finding rules clear were of significantly greater importance to their well-being.\n\nThe findings highlight that the socio-ecological factors of resilience, social support, doing useful work and finding the rules clear affect well-being. The results also indicate that it is vital to consider factors at multiple socio-ecological levels to improve the well-being of the self-employed during adversity.", "doi": "10.3390/ijerph19137840", "pmid": "35805499", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19137840"}, {"db": "pmc", "key": "PMC9266291"}], "notes": [], "created": "2022-08-17T10:43:44.466Z", "modified": "2022-08-17T10:43:53.138Z"}, {"entity": "publication", "iuid": "375d0e6589464233885e6d24fbf73de0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/375d0e6589464233885e6d24fbf73de0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/375d0e6589464233885e6d24fbf73de0"}}, "title": "Epigenetic rewiring of pathways related to odour perception in immune cells exposed to SARS-CoV-2 in vivo and in vitro.", "authors": [{"family": "Huoman", "given": "Johanna", "initials": "J", "orcid": "0000-0003-2509-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83ac07f7b8c64d0090490070a3893006.json"}}, {"family": "Sayyab", "given": "Shumaila", "initials": "S", "orcid": "0000-0002-6048-775X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80e824deb3c54d2089f6615099188de1.json"}}, {"family": "Apostolou", "given": "Eirini", "initials": "E"}, {"family": "Karlsson", "given": "Lovisa", "initials": "L", "orcid": "0000-0003-2704-1788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2776385bc7d6419cb4378f33422425a0.json"}}, {"family": "Porcile", "given": "Lucas", "initials": "L", "orcid": "0000-0002-9164-4113", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4fe6ded8a7f74d64b9f1082da69f19ff.json"}}, {"family": "Rizwan", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-1725-8337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8aa9753dd6ae4622915f731fd54edf54.json"}}, {"family": "Sharma", "given": "Sumit", "initials": "S", "orcid": "0000-0003-0299-1285", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b6ce9aac5824a6f8d034a62e95f642f.json"}}, {"family": "Das", "given": "Jyotirmoy", "initials": "J", "orcid": "0000-0002-5649-4658", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/883ec5a66e47458fa303f9df2572f669.json"}}, {"family": "Ros\u00e9n", "given": "Anders", "initials": "A", "orcid": "0000-0001-5082-6423", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49ec1de9d88d4124a265b477662f0d0a.json"}}, {"family": "Lerm", "given": "Maria", "initials": "M", "orcid": "0000-0002-5092-9892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a326e1fb7efa4c4f8f59e7572f6b83bc.json"}}], "type": "journal article", "published": "2022-06-26", "journal": {"title": "Epigenetics", "issn": "1559-2308", "pages": "1-17", "issn-l": null}, "abstract": "A majority of SARS-CoV-2 recoverees develop only mild-to-moderate symptoms, while some remain completely asymptomatic. Although viruses, including SARS-CoV-2, may evade host immune responses by epigenetic mechanisms including DNA methylation, little is known about whether these modifications are important in defence against and healthy recovery from COVID-19 in the host. To this end, epigenome-wide DNA methylation patterns from COVID-19 convalescents were compared to uninfected controls from before and after the pandemic. Peripheral blood mononuclear cell (PBMC) DNA was extracted from uninfected controls, COVID-19 convalescents, and symptom-free individuals with SARS-CoV-2-specific T cell-responses, as well as from PBMCs stimulated in vitro with SARS-CoV-2. Subsequently, the Illumina MethylationEPIC 850K array was performed, and statistical/bioinformatic analyses comprised differential DNA methylation, pathway over-representation, and module identification analyses. Differential DNA methylation patterns distinguished COVID-19 convalescents from uninfected controls, with similar results in an experimental SARS-CoV-2 infection model. A SARS-CoV-2-induced module was identified in vivo, comprising 66 genes of which six (TP53, INS, HSPA4, SP1, ESR1, and FAS) were present in corresponding in vitro analyses. Over-representation analyses revealed involvement in Wnt, muscarinic acetylcholine receptor signalling, and gonadotropin-releasing hormone receptor pathways. Furthermore, numerous differentially methylated and network genes from both settings interacted with the SARS-CoV-2 interactome. Altered DNA methylation patterns of COVID-19 convalescents suggest recovery from mild-to-moderate SARS-CoV-2 infection leaves longstanding epigenetic traces. Both in vitro and in vivo exposure caused epigenetic modulation of pathways thataffect odour perception. Future studies should determine whether this reflects host-induced protective antiviral defense or targeted viral hijacking to evade host defence.", "doi": "10.1080/15592294.2022.2089471", "pmid": "35758003", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-19T05:37:15.000Z", "modified": "2022-08-19T05:37:15.278Z"}, {"entity": "publication", "iuid": "edd352e915f645408a416238fae795a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/edd352e915f645408a416238fae795a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/edd352e915f645408a416238fae795a1"}}, "title": "Seroprevalence of SARS-CoV-2 in Sweden, April 26 to May 9, 2021.", "authors": [{"family": "Beser", "given": "Jessica", "initials": "J"}, {"family": "Galanis", "given": "Ilias", "initials": "I"}, {"family": "Enkirch", "given": "Theresa", "initials": "T"}, {"family": "K\u00fchlmann Berenzon", "given": "Sharon", "initials": "S"}, {"family": "van Straten", "given": "Edward", "initials": "E"}, {"family": "Duracz", "given": "Jan", "initials": "J"}, {"family": "Rapp", "given": "Marie", "initials": "M"}, {"family": "Zakikhany", "given": "Katherina", "initials": "K"}, {"family": "Mansj\u00f6", "given": "Mikael", "initials": "M"}, {"family": "Wigren Bystr\u00f6m", "given": "Julia", "initials": "J"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Groenheit", "given": "Ramona", "initials": "R"}, {"family": "Tegmark Wisell", "given": "Karin", "initials": "K"}, {"family": "Br\u00e5ve", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2022-06-25", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "10816", "issn-l": "2045-2322"}, "abstract": "A national point seroprevalence study of SARS-CoV-2 was conducted in Sweden in April-May 2021. In total, 2860 individuals 3 to 90 years old from a probability-based web panel were included. Results showed that an estimated 32.6% of the population in Sweden had detectable levels of antibodies, and among non-vaccinated 20.1% had detectable levels of antibodies. We tested for differences in seroprevalence between age groups and by sex and estimated seroprevalence among previously infected participants by time since reporting.", "doi": "10.1038/s41598-022-15183-w", "pmid": "35752708", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-15183-w"}, {"db": "pmc", "key": "PMC9233662"}], "notes": [], "created": "2022-08-19T05:40:11.690Z", "modified": "2022-08-19T05:40:11.696Z"}, {"entity": "publication", "iuid": "49204daeaf184d10a9cef9d6c9613fc1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49204daeaf184d10a9cef9d6c9613fc1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49204daeaf184d10a9cef9d6c9613fc1"}}, "title": "Quality of life among health care workers with and without prior COVID-19 infection in Bangladesh.", "authors": [{"family": "Rahman", "given": "Mahfil Ara", "initials": "MA"}, {"family": "Sagar", "given": "Soumik Kha", "initials": "SK"}, {"family": "Dalal", "given": "Koustuv", "initials": "K", "orcid": "0000-0001-7393-796X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab5e44a17b7545988cb46cdf5b1f3e4e.json"}}, {"family": "Barsha", "given": "Sabrina Yesmin", "initials": "SY"}, {"family": "Ara", "given": "Tasnim", "initials": "T"}, {"family": "Khan", "given": "Md Abdullah Saeed", "initials": "MAS"}, {"family": "Saha", "given": "Shuvajit", "initials": "S"}, {"family": "Sarmin", "given": "Tanjina", "initials": "T"}, {"family": "Hossian", "given": "Mosharop", "initials": "M"}, {"family": "Nabi", "given": "Mohammad Hayatun", "initials": "MH"}, {"family": "Rahman", "given": "Mohammad Lutfor", "initials": "ML"}, {"family": "Hawlader", "given": "Mohammad Delwer Hossain", "initials": "MDH"}], "type": "journal article", "published": "2022-06-25", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "volume": "22", "issue": "1", "pages": "823", "issn-l": null}, "abstract": "Health care workers have been facing difficulties in coping with the COVID-19 infection from the beginning. The study aimed to compare Quality of Life (QOL) among health care workers (HCWs) with and without prior COVID-19 disease.\n\nThis study was conducted from July 2020 to January 2021 among 444 HCWs. We randomly interviewed 3244 participants for our earlier nationwide survey from a list of COVID-19 positive cases after their recovery, and we found 222 HCWs among the respondents. We randomly chose 222 HCWs unaffected by COVID as a comparison group from our selected hospitals. We measured QOL using World Health Organization's WHOQOL-BREF tool. Physical, psychological, environmental, and social ties were the four areas assessed on a 5-point Likert scale where a higher score suggests better QOL. Due to pandemic restrictions, we used telephonic interviews for data collection.\n\nA higher QOL score was observed in HCWs with prior COVID-19 infection in all four domains than HCWs without previous COVID-19 conditions. Comorbidity was negatively associated with QOL scores of the physical (p = 0.001) and (p < 0.001) and psychological (p = 0.05, and (p < 0.05) domains for non-COVID and COVID-affected groups, respectively. Current smoking was significantly associated with lower psychological (p = 0.019) and environmental (p = 0.007) QOL scores among HCWs with prior COVID-19 infection. Hospitalization history due to COVID infection was a contributing factor for lower physical QOL scores (p = 0.048). Environmental (p = 0.016) QOL scores were significantly associated with the monthly income in the prior COVID-19 infection group, and physical scores were significantly associated (p = 0.05) with a monthly income in the non-COVID group.\n\nGovernmental and non-governmental stakeholders should focus on potentially modifiable factors to improve health care workers' quality of life.", "doi": "10.1186/s12913-022-08174-0", "pmid": "35752784", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-022-08174-0"}, {"db": "pmc", "key": "PMC9233781"}], "notes": [], "created": "2022-08-19T05:39:51.105Z", "modified": "2022-08-19T05:39:51.148Z"}, {"entity": "publication", "iuid": "24907a395ed8437eb499edb4f4697bd8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24907a395ed8437eb499edb4f4697bd8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24907a395ed8437eb499edb4f4697bd8"}}, "title": "Have Health Inequalities Increased during the COVID-19 Pandemic? Evidence from Recent Years for Older European Union Citizens.", "authors": [{"family": "Gonz\u00e1lez Rodr\u00edguez", "given": "Irene", "initials": "I"}, {"family": "Pascual S\u00e1ez", "given": "Marta", "initials": "M"}, {"family": "Cantarero Prieto", "given": "David", "initials": "D"}], "type": "journal article", "published": "2022-06-25", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "13", "issn-l": null}, "abstract": "Reducing inequality is one of the current challenges that most societies are facing. Our aim was to analyze the evolution of inequalities in self-assessed health among older Europeans in a time period spanning the 2008 economic crisis and the COVID-19 health crisis. We used data from Waves 2, 4 and 8 of the Survey of Health, Ageing and Retirement in Europe. We used inequality indices that accept ordinal variables. Our empirical results suggest that average inequality declines over time. Gender significantly influences the results. Some of the countries with the highest level of inequality are Denmark and Sweden, and some with the lowest are Estonia and the Netherlands. Our results may be of interest for the development of public policies to reduce inequalities. Special attention should be paid to vulnerable groups, such as the elderly.", "doi": "10.3390/ijerph19137812", "pmid": "35805469", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19137812"}, {"db": "pmc", "key": "PMC9265733"}], "notes": [], "created": "2022-08-17T10:44:08.425Z", "modified": "2022-08-17T10:44:08.442Z"}, {"entity": "publication", "iuid": "1ce2276235264619893a58a1534fe868", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ce2276235264619893a58a1534fe868.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ce2276235264619893a58a1534fe868"}}, "title": "Children with psoriasis and COVID-19: factors associated with an unfavourable COVID-19 course, and the impact of infection on disease progression (Chi-PsoCov registry).", "authors": [{"family": "Zitouni", "given": "J", "initials": "J"}, {"family": "Bursztejn", "given": "A-C", "initials": "AC"}, {"family": "Belloni Fortina", "given": "A", "initials": "A", "orcid": "0000-0001-5791-0775", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f10eaae7700c4eee85c4bbd8947f5d21.json"}}, {"family": "Beauchet", "given": "A", "initials": "A"}, {"family": "Di Lernia", "given": "V", "initials": "V"}, {"family": "Lesiak", "given": "A", "initials": "A"}, {"family": "Thomas", "given": "J", "initials": "J"}, {"family": "Topkarci", "given": "Z", "initials": "Z"}, {"family": "Murashkin", "given": "N", "initials": "N", "orcid": "0000-0003-2252-8570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/780f117056524c3686f523771c79c35e.json"}}, {"family": "Brzezinski", "given": "P", "initials": "P", "orcid": "0000-0001-6817-606X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c59b93962ec045b39373303e1bdbd518.json"}}, {"family": "Torres", "given": "T", "initials": "T", "orcid": "0000-0003-0404-0870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54a6d84c2e9045eab3f506c4860aaeb3.json"}}, {"family": "Chiriac", "given": "A", "initials": "A", "orcid": "0000-0002-0989-4931", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a50fa61a4dc4d728e42c620fc06e8d0.json"}}, {"family": "Luca", "given": "C", "initials": "C"}, {"family": "McPherson", "given": "T", "initials": "T"}, {"family": "Akinde", "given": "M", "initials": "M"}, {"family": "Maruani", "given": "A", "initials": "A"}, {"family": "Epishev", "given": "R", "initials": "R"}, {"family": "Vidaurri de la Cruz", "given": "H", "initials": "H"}, {"family": "Luna", "given": "P C", "initials": "PC"}, {"family": "Amy de la Bret\u00eaque", "given": "M", "initials": "M"}, {"family": "Lasek", "given": "A", "initials": "A", "orcid": "0000-0002-4105-4027", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68e435ca02b345d6902a366c4e8e1879.json"}}, {"family": "Bourrat", "given": "E", "initials": "E"}, {"family": "Bachelerie", "given": "M", "initials": "M"}, {"family": "Mallet", "given": "S", "initials": "S"}, {"family": "Steff", "given": "M", "initials": "M"}, {"family": "Bellissen", "given": "A", "initials": "A"}, {"family": "Neri", "given": "I", "initials": "I"}, {"family": "Zafiriou", "given": "E", "initials": "E", "orcid": "0000-0002-6594-7292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/99d5a40411774f848f72fd5df470583c.json"}}, {"family": "van den Reek", "given": "J M P A", "initials": "JMPA"}, {"family": "Sonkoly", "given": "E", "initials": "E", "orcid": "0000-0002-4909-5413", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc17777e8b4e43ef918ddf68d3dce068.json"}}, {"family": "Mahil", "given": "S K", "initials": "SK"}, {"family": "Smith", "given": "C H", "initials": "CH", "orcid": "0000-0001-9918-1144", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4d49fa2c6a44215b42d5ee1e2e81190.json"}}, {"family": "Flohr", "given": "C", "initials": "C", "orcid": "0000-0003-4884-6286", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13d37914df3244d5ae62b9ece4ce2602.json"}}, {"family": "Bachelez", "given": "H", "initials": "H"}, {"family": "Mah\u00e9", "given": "E", "initials": "E", "orcid": "0000-0001-5780-1827", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f2012056d0e14e66a2d7f97812a768a5.json"}}, {"family": "Groupe de Recherche sur le Psoriasis (GrPso) of the Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie, the Groupe de recherche de la Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie P\u00e9diatrique (GR SFDP), the PsoProtect study group, the British Society of Paediatric Dermatology (BPSD), and the Societ\u00e0 Italiana di Dermatologia Pediatrica (S.I.Der.P.)", "given": "", "initials": ""}], "type": "journal article", "published": "2022-06-24", "journal": {"title": "J Eur Acad Dermatol Venereol", "issn": "1468-3083", "issn-l": null}, "abstract": "The COVID-19 pandemic has raised questions regarding the management of chronic skin diseases, especially in patients on systemic treatments. Data concerning the use of biologics in adults with psoriasis are reassuring, but data specific to children are missing. Moreover, COVID-19 could impact the course of psoriasis in children.\n\nThe aim of this study was therefore to assess the impact of COVID-19 on the psoriasis of children, and the severity of the infection in relation to systemic treatments.\n\nWe set up an international registry of paediatric psoriasis patients. Children were included if they were under 18 years of age, had a history of psoriasis, or developed it within 1 month of COVID-19 and had COVID-19 with or without symptoms.\n\nOne hundred and twenty episodes of COVID-19 in 117 children (mean age: 12.4 years) were reported. The main clinical form of psoriasis was plaque type (69.4%). Most children were without systemic treatment (54.2%); 33 (28.3%) were on biologic therapies, and 24 (20%) on non-biologic systemic drugs. COVID-19 was confirmed in 106 children (88.3%) and 3 children had two COVID-19 infections each. COVID-19 was symptomatic for 75 children (62.5%) with a mean duration of 6.5 days, significantly longer for children on non-biologic systemic treatments (P = 0.02) and without systemic treatment (P = 0.006) when compared with children on biologics. The six children who required hospitalization were more frequently under non-biologic systemic treatment when compared with the other children (P = 0.01), and particularly under methotrexate (P = 0.03). After COVID-19, the psoriasis worsened in 17 cases (15.2%). Nine children (8%) developed a psoriasis in the month following COVID-19, mainly a guttate form (P = 0.01).\n\nBiologics appear to be safe with no increased risk of severe form of COVID-19 in children with psoriasis. COVID-19 was responsible for the development of psoriasis or the worsening of a known psoriasis for some children.", "doi": "10.1111/jdv.18361", "pmid": "35748102", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9349726"}], "notes": [], "created": "2022-08-19T05:40:29.879Z", "modified": "2022-08-19T05:40:49.724Z"}, {"entity": "publication", "iuid": "ebacd66fb4254d659f20819fbec4c072", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ebacd66fb4254d659f20819fbec4c072.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ebacd66fb4254d659f20819fbec4c072"}}, "title": "Susceptibility of Patients with Asthma to Poor Outcome of COVID-19.", "authors": [{"family": "Persson", "given": "Carl", "initials": "C"}], "type": "journal article", "published": "2022-06-23", "journal": {"title": "Am J Respir Crit Care Med", "issn": "1535-4970", "issn-l": "1073-449X"}, "abstract": null, "doi": "10.1164/rccm.202205-0978LE", "pmid": "35737585", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-19T05:50:50.241Z", "modified": "2022-08-19T05:50:50.255Z"}, {"entity": "publication", "iuid": "649df7de666440e992c1c66547d697d6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/649df7de666440e992c1c66547d697d6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/649df7de666440e992c1c66547d697d6"}}, "title": "Long-COVID in children and adolescents: a systematic review and meta-analyses.", "authors": [{"family": "Lopez-Leon", "given": "Sandra", "initials": "S", "orcid": "0000-0001-7504-3441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/311cfec51fe9447283ee5c3a4ca0a3cd.json"}}, {"family": "Wegman-Ostrosky", "given": "Talia", "initials": "T", "orcid": "0000-0002-3207-6697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ebacfc4db6e4a04aab46b7172d828f2.json"}}, {"family": "Ayuzo Del Valle", "given": "Norma Cipatli", "initials": "NC", "orcid": "0000-0002-8110-3532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/222db71f009442798ef9b2ac782bb312.json"}}, {"family": "Perelman", "given": "Carol", "initials": "C", "orcid": "0000-0002-0111-1154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb4874d2c45c4d698c57f5e3705d306d.json"}}, {"family": "Sepulveda", "given": "Rosalinda", "initials": "R", "orcid": "0000-0003-1146-9552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e217c9ab8c24eeca127ffb1dd89b843.json"}}, {"family": "Rebolledo", "given": "Paulina A", "initials": "PA", "orcid": "0000-0002-9808-063X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bbee43f79e147b39028119e0b573c72.json"}}, {"family": "Cuapio", "given": "Angelica", "initials": "A", "orcid": "0000-0002-9451-1914", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f4915fdfa7d460f9b705b56b0fc1c4a.json"}}, {"family": "Villapol", "given": "Sonia", "initials": "S", "orcid": "0000-0002-6174-4113", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04eb73dcc16546b0b153a41bcba039af.json"}}], "type": "journal article", "published": "2022-06-23", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "9950", "issn-l": "2045-2322"}, "abstract": "The objective of this systematic review and meta-analyses is to estimate the prevalence of long-COVID in children and adolescents and to present the full spectrum of symptoms present after acute COVID-19. We have used PubMed and Embase to identify observational studies published before February 10th, 2022 that included a minimum of 30 patients with ages ranging from 0 to 18 years that met the National Institute for Healthcare Excellence (NICE) definition of long-COVID, which consists of both ongoing (4 to 12 weeks) and post-COVID-19 (\u2265 12 weeks) symptoms. Random-effects meta-analyses were performed using the MetaXL software to estimate the pooled prevalence with a 95% confidence interval (CI). Heterogeneity was assessed using I2 statistics. The Preferred Reporting Items for Systematic Reviewers and Meta-analysis (PRISMA) reporting guideline was followed (registration PROSPERO CRD42021275408). The literature search yielded 8373 publications, of which 21 studies met the inclusion criteria, and a total of 80,071 children and adolescents were included. The prevalence of long-COVID was 25.24%, and the most prevalent clinical manifestations were mood symptoms (16.50%), fatigue (9.66%), and sleep disorders (8.42%). Children infected by SARS-CoV-2 had a higher risk of persistent dyspnea, anosmia/ageusia, and/or fever compared to controls. Limitations of the studies analyzed include lack of standardized definitions, recall, selection, misclassification, nonresponse and/or loss of follow-up, and a high level of heterogeneity.", "doi": "10.1038/s41598-022-13495-5", "pmid": "35739136", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-13495-5"}, {"db": "pmc", "key": "PMC9226045"}], "notes": [], "created": "2022-08-19T05:50:23.537Z", "modified": "2022-08-19T05:50:30.738Z"}, {"entity": "publication", "iuid": "bf54121e5e9c41c7922320e941b41e55", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf54121e5e9c41c7922320e941b41e55.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf54121e5e9c41c7922320e941b41e55"}}, "title": "English dictionaries, gold and silver standard corpora for biomedical natural language processing related to SARS-CoV-2 and COVID-19", "authors": [{"family": "Kazemi Rashed", "given": "S", "initials": "S"}, {"family": "Ahmed", "given": "R", "initials": "R"}, {"family": "Frid", "given": "J", "initials": "J"}, {"family": "Aits", "given": "S", "initials": "S"}], "type": null, "published": "2022-06-23", "journal": {"title": "Arxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "https://doi.org/10.48550/arXiv.2003.09865", "pmid": null, "labels": {"Category: Health": null, "Type: Preprint": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "SRA", "key": "https://github.com/Aitslab/corona", "description": "https://github.com/Aitslab/corona"}, {"db": "URL", "key": "https://doi.org/10.5281/zenodo.6642275", "description": "https://doi.org/10.5281/zenodo.6642275"}], "notes": [], "created": "2022-06-23T06:26:18.948Z", "modified": "2023-02-22T08:06:48.608Z"}, {"entity": "publication", "iuid": "07b7e771e6d74fff82e04ed1d6be5533", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07b7e771e6d74fff82e04ed1d6be5533.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07b7e771e6d74fff82e04ed1d6be5533"}}, "title": "COVID-19 vaccine-induced adverse events predict immunogenicity among recipients of allogeneic haematopoietic stem cell transplantation.", "authors": [{"family": "Wiktorin", "given": "Hanna Grauers", "initials": "HG"}, {"family": "Einarsdottir", "given": "Sigrun", "initials": "S"}, {"family": "T\u00f6rnell", "given": "Andreas", "initials": "A"}, {"family": "Arabpour", "given": "Mohammad", "initials": "M"}, {"family": "Issdisai", "given": "Nuttida", "initials": "N"}, {"family": "Waldenstr\u00f6m", "given": "Jesper", "initials": "J"}, {"family": "Ringlander", "given": "Johan", "initials": "J"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K"}, {"family": "Martner", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-06-23", "journal": {"title": "Haematologica", "issn": "1592-8721", "issn-l": null}, "abstract": "Not available.", "doi": "10.3324/haematol.2022.280813", "pmid": "35734932", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-19T05:51:10.760Z", "modified": "2022-08-19T05:51:29.781Z"}, {"entity": "publication", "iuid": "4146548be296461e80f0b92a21d97c59", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4146548be296461e80f0b92a21d97c59.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4146548be296461e80f0b92a21d97c59"}}, "title": "Neurological Involvement in COVID-19 Among Non-Hospitalized Adolescents and Young Adults.", "authors": [{"family": "Havdal", "given": "Lise Beier", "initials": "LB"}, {"family": "Berven", "given": "Lise Lund", "initials": "LL"}, {"family": "Selvakumar", "given": "Joel", "initials": "J"}, {"family": "Stiansen-Sonerud", "given": "Tonje", "initials": "T"}, {"family": "Leegaard", "given": "Truls Michael", "initials": "TM"}, {"family": "Tjade", "given": "Trygve", "initials": "T"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Wyller", "given": "Vegard Bruun Bratholm", "initials": "VBB"}], "type": "journal article", "published": "2022-06-22", "journal": {"title": "Front Neurol", "issn": "1664-2295", "volume": "13", "pages": "915712", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) is prevalent among young people, and neurological involvement has been reported. We investigated neurological symptoms, cognitive test results, and biomarkers of brain injury, as well as associations between these variables in non-hospitalized adolescents and young adults with COVID-19.\n\nThis study reports baseline findings from an ongoing observational cohort study of COVID-19 cases and non-COVID controls aged 12-25 years (Clinical Trials ID: NCT04686734). Symptoms were charted using a standardized questionnaire. Cognitive performance was evaluated by applying tests of working memory, verbal learning, delayed recall, and recognition. The brain injury biomarkers, neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAp), were assayed in serum samples using ultrasensitive immunoassays.\n\nA total of 405 COVID-19 cases and 111 non-COVID cases were prospectively included. Serum Nfl and GFAp concentrations were significantly elevated in COVID-19 cases as compared with non-COVID controls (p = 0.050 and p = 0.014, respectively). The COVID-19 cases reported more fatigue (p < 0.001) and post-exertional malaise (PEM) (p = 0.001) compared to non-COVID-19 controls. Cognitive test performance and clinical neurological examination did not differ across the two groups. Within the COVID-19 group, there were no associations between symptoms, cognitive test results, and NfL or GFAp levels. However, fatigue and PEM were strongly associated with older age and female sex.\n\nNon-hospitalized adolescents and young adults with COVID-19 reported more fatigue and PEM and had slightly elevated levels of brain injury markers, but showed normal cognitive performance. No associations were found between symptoms, brain injury markers, and cognitive test results, but fatigue and PEM were strongly related to female sex and older age.", "doi": "10.3389/fneur.2022.915712", "pmid": "35812102", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9257204"}], "notes": [], "created": "2022-08-17T10:39:11.368Z", "modified": "2022-08-17T10:39:11.383Z"}, {"entity": "publication", "iuid": "3b9514af60f34b5a864db3b1ab5544eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b9514af60f34b5a864db3b1ab5544eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b9514af60f34b5a864db3b1ab5544eb"}}, "title": "Agile software development one year into the COVID-19 pandemic.", "authors": [{"family": "\u00c5gren", "given": "Pernilla", "initials": "P"}, {"family": "Knoph", "given": "Eli", "initials": "E"}, {"family": "Berntsson Svensson", "given": "Richard", "initials": "R"}], "type": "journal article", "published": "2022-06-22", "journal": {"title": "Empir Softw Eng", "issn": "1573-7616", "issn-l": null, "volume": "27", "issue": "6", "pages": "121"}, "abstract": "As a result of the COVID-19 pandemic, many agile practitioners had to transition into a remote work environment. Despite remote work not being a new concept for agile software practitioners, the forced or recommended nature of remote work is new. This study investigates how the involuntary shift to remote work and how social restrictions imposed by the COVID-19 pandemic have affected agile software development (ASD), and how agile practitioners have been affected in terms of ways of working. An explanatory sequential mixed methods study was performed. Data were collected one year into the COVID-19 pandemic through a questionnaire with 96 respondents and in-depth semi-structured interviews with seven practitioners from seven different companies. Data were analyzed through Bayesian analysis and thematic analysis. The results show, in general, that the aspects of ASD that have been the most affected is communication and social interactions, while technical work aspects have not experienced the same changes. Moreover, feeling forced to work remotely has a significant impact on different aspects of ASD, e.g., productivity and communication, and industry practitioners' employment of agile development and ways of working have primarily been affected by the lack of social interaction and the shift to digital communication. The results also suggest that there may be a group maturing debt when teams do go back into office, as digital communication and the lack of psychological safety stand in the way for practitioners' ability to have sensitive discussions and progress as a team in a remote setting.", "doi": "10.1007/s10664-022-10176-9", "pmid": "35757145", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10176"}, {"db": "pmc", "key": "PMC9214195"}], "notes": [], "created": "2022-08-19T05:38:34.428Z", "modified": "2022-11-09T08:40:12.194Z"}, {"entity": "publication", "iuid": "9a83041a95b949c2a1e8748cf44d5cd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9a83041a95b949c2a1e8748cf44d5cd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9a83041a95b949c2a1e8748cf44d5cd0"}}, "title": "S100A4 exerts robust mucosal adjuvant activity for co-administered antigens in mice.", "authors": [{"family": "Sen Chaudhuri", "given": "Arka", "initials": "A"}, {"family": "Yeh", "given": "Yu-Wen", "initials": "YW"}, {"family": "Zewdie", "given": "Olifan", "initials": "O"}, {"family": "Li", "given": "Nga Shan", "initials": "NS"}, {"family": "Sun", "given": "Jia-Bin", "initials": "JB"}, {"family": "Jin", "given": "Tao", "initials": "T"}, {"family": "Wei", "given": "Bin", "initials": "B"}, {"family": "Holmgren", "given": "Jan", "initials": "J"}, {"family": "Xiang", "given": "Zou", "initials": "Z", "orcid": "0000-0003-3925-0296", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61c1684aa00746dfae1bad8c84111033.json"}}], "type": "journal article", "published": "2022-06-21", "journal": {"title": "Mucosal Immunol", "issn": "1935-3456", "issn-l": null}, "abstract": "The lack of clinically applicable mucosal adjuvants is a major hurdle in designing effective mucosal vaccines. We hereby report that the calcium-binding protein S100A4, which regulates a wide range of biological functions, is a potent mucosal adjuvant in mice for co-administered antigens, including the SARS-CoV-2 spike protein, with comparable or even superior efficacy as cholera toxin but without causing any adverse reactions. Intranasal immunization with recombinant S100A4 elicited antigen-specific antibody and pulmonary cytotoxic T cell responses, and these responses were remarkably sustained for longer than 6 months. As a self-protein, S100A4 did not stimulate antibody responses against itself, a quality desired of adjuvants. S100A4 prolonged nasal residence of intranasally delivered antigens and promoted migration of antigen-presenting cells. S100A4-pulsed dendritic cells potently activated cognate T cells. Furthermore, S100A4 induced strong germinal center responses revealed by both microscopy and mass spectrometry, a novel label-free technique for measuring germinal center activity. Importantly, S100A4 did not induce olfactory bulb inflammation after nasal delivery, which is often a safety concern for nasal vaccination. In conclusion, S100A4 may be a promising adjuvant in formulating mucosal vaccines, including vaccines against pathogens that infect via the respiratory tract, such as SARS-CoV-2.", "doi": "10.1038/s41385-022-00535-6", "pmid": "35729204", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41385-022-00535-6"}, {"db": "pmc", "key": "PMC9212208"}], "notes": [], "created": "2022-08-17T13:06:09.232Z", "modified": "2022-08-17T13:06:09.309Z"}, {"entity": "publication", "iuid": "be0427dd3a9f4cb0b82fdfd48240a897", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be0427dd3a9f4cb0b82fdfd48240a897.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be0427dd3a9f4cb0b82fdfd48240a897"}}, "title": "Incidence of acute myocardial injury and its association with left and right ventricular systolic dysfunction in critically ill COVID-19 patients.", "authors": [{"family": "Jansson", "given": "Saga", "initials": "S"}, {"family": "Blixt", "given": "Patrik Johansson", "initials": "PJ"}, {"family": "Didriksson", "given": "Helen", "initials": "H"}, {"family": "Jonsson", "given": "Carina", "initials": "C"}, {"family": "Andersson", "given": "Henrik", "initials": "H"}, {"family": "Hedstr\u00f6m", "given": "Cassandra", "initials": "C"}, {"family": "Engvall", "given": "Jan", "initials": "J"}, {"family": "Aneq", "given": "Meriam \u00c5strom", "initials": "M\u00c5"}, {"family": "Chew", "given": "Michelle S", "initials": "MS", "orcid": "0000-0003-2888-4111", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c68391bb66e94be1ac0a14d69430666e.json"}}], "type": "journal article", "published": "2022-06-21", "journal": {"title": "Ann Intensive Care", "issn": "2110-5820", "volume": "12", "issue": "1", "pages": "56", "issn-l": null}, "abstract": "Previous studies have found an increase in cardiac troponins (cTns) and echocardiographic abnormalities in patients with COVID-19 and reported their association with poor clinical outcomes. Whether acute injury occurs during the course of critical care and if it is associated with cardiac function is unknown. The purpose of this study was to document the incidence of acute myocardial injury (AMInj) and echocardiographically defined left ventricular (LV) and right ventricular (RV) systolic dysfunction in consecutive patients admitted to an intensive care unit (ICU) for COVID-19. The relationship between AMInj and echocardiographic abnormalities during the first 14 days of ICU admission was studied. Finally, the association between echocardiographic findings, AMInj and clinical outcome was evaluated.\n\nSeventy-four consecutive patients (\u226518 years) admitted to the ICU at Link\u00f6ping University Hospital between 19 Mar 2020 and 31 Dec 2020 for COVID-19 were included. High-sensitivity troponin-T (hsTnT) was measured daily for up to 14 days. Transthoracic echocardiography was conducted within 72 h of ICU admission. Acute myocardial injury was defined as an increased hsTnT > 14ng/l and a > 20% absolute change with or without ischaemic symptoms. LV and RV systolic dysfunction was defined as at least 2 abnormal indicators of systolic function specified by consensus guidelines.\n\nIncreased hsTnT was observed in 59% of patients at ICU admission, and 82% developed AMInj with peak levels at 8 (3-13) days after ICU admission. AMInj was not statistically significantly associated with 30-day mortality but was associated with an increased duration of invasive mechanical ventilation (10 (3-13) vs. 5 days (0-9), p=0.001) as well as ICU length of stay (LOS) (19.5 (11-28) vs. 7 days (5-13), p=0.015). After adjustment for SAPS-3 and admission SOFA score, the effect of AMInj was significant only for the duration of mechanical ventilation (p=0.030). The incidence of LV and RV dysfunction was 28% and 22%, respectively. Only indices of LV and RV longitudinal contractility (mitral and tricuspid annular plane systolic excursion) were associated with AMInj. Echocardiographic parameters were not associated with clinical outcome.\n\nMyocardial injury is common in critically ill patients with COVID-19, with AMInj developing in more than 80% after ICU admission. In contrast, LV and RV dysfunction occurred in approximately one-quarter of patients. AMInj was associated with an increased need for mechanical ventilation and ICU LOS but neither AMInj nor ventricular dysfunction was significantly associated with mortality.", "doi": "10.1186/s13613-022-01030-8", "pmid": "35727386", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13613-022-01030-8"}, {"db": "pmc", "key": "PMC9210044"}], "notes": [], "created": "2022-08-17T13:05:26.592Z", "modified": "2022-08-17T13:05:26.639Z"}, {"entity": "publication", "iuid": "8c8b3c1318b14711a433112dcbf8867b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c8b3c1318b14711a433112dcbf8867b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c8b3c1318b14711a433112dcbf8867b"}}, "title": "Building social support: The impact of workgroup characteristics, the COVID-19 pandemic and informal interactions.", "authors": [{"family": "Pauksztat", "given": "Birgit", "initials": "B", "orcid": "0000-0002-2216-0836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c1db1125035420a81d17521e7a82755.json"}}, {"family": "Grech", "given": "Michelle R", "initials": "MR", "orcid": "0000-0002-3323-3607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b2aceb4dce745d780f36935b82dcb85.json"}}], "type": "journal article", "published": "2022-06-21", "journal": {"title": "Work", "issn": "1875-9270", "pages": "1175-1189", "volume": "72", "issue": "4", "issn-l": null}, "abstract": "Social support from colleagues is a key resource for employees and organizations, with beneficial effects on performance, employee well-being and resilience. Although the importance of social support is well-known, the factors that help to build and maintain social support are not equally well understood.\n\nThis study analyzes the impact of workgroup characteristics (i.e., workgroup composition regarding national diversity and tenure; workload) and the COVID-19 pandemic on employees' perceptions of instrumental and emotional support, and examines the mediating role of informal interactions.\n\nThe study is based on responses from 382 seafarers to a cross-sectional online survey. Hypotheses were tested using OLS regression and mediation analysis using PROCESS.\n\nWorkgroup composition regarding national diversity had indirect effects on social support through informal interactions around social foci (here: joint leisure activities). High workload and pressure from the COVID-19 pandemic reduced interactions around social foci, thus contributing to the erosion of perceived social support.\n\nThe findings provide insights on the development of social support, suggesting that informal interactions provide an important mechanism for the development of social support at work. From a theoretical perspective, this highlights the value of a relational perspective on the development of social support, a perspective that is based on the insight that social support is embedded in social relationships. From a practical point of view, this indicates that organizations can proactively foster the development of social support through practices that shape workgroup characteristics and social foci.", "doi": "10.3233/WOR-220020", "pmid": "35723163", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "WOR220020"}], "notes": [], "created": "2022-06-20T18:03:34.602Z", "modified": "2022-08-17T12:45:15.461Z"}, {"entity": "publication", "iuid": "10d1edf47a3741b49c5ce19be486db55", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/10d1edf47a3741b49c5ce19be486db55.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/10d1edf47a3741b49c5ce19be486db55"}}, "title": "Broadly Applicable, Virus-Free Dual Reporter Assay to Identify Compounds Interfering with Membrane Fusion: Performance for HSV-1 and SARS-CoV-2.", "authors": [{"family": "Classen", "given": "Nica", "initials": "N", "orcid": "0000-0002-2745-5748", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ac354339de048e4ba9a7903e4fe8c30.json"}}, {"family": "Ulrich", "given": "Diana", "initials": "D"}, {"family": "Hofemeier", "given": "Arne", "initials": "A"}, {"family": "Hennies", "given": "Marc Tim", "initials": "MT"}, {"family": "Hafezi", "given": "Wali", "initials": "W"}, {"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Romberg", "given": "Marie-Luise", "initials": "ML"}, {"family": "Lorentzen", "given": "Eva U", "initials": "EU", "orcid": "0000-0002-5570-1897", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9d0581149694958919de3f8fe6ef3cc.json"}}, {"family": "Hensel", "given": "Andreas", "initials": "A", "orcid": "0000-0003-0886-8384", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/458c0b3e8d9a47c083f86f80f542b582.json"}}, {"family": "K\u00fchn", "given": "Joachim E", "initials": "JE"}], "type": "journal article", "published": "2022-06-21", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "7", "issn-l": "1999-4915"}, "abstract": "Membrane fusion constitutes an essential step in the replication cycle of numerous viral pathogens, hence it represents an important druggable target. In the present study, we established a virus-free, stable reporter fusion inhibition assay (SRFIA) specifically designed to identify compounds interfering with virus-induced membrane fusion. The dual reporter assay is based on two stable Vero cell lines harboring the third-generation tetracycline (Tet3G) transactivator and a bicistronic reporter gene cassette under the control of the tetracycline responsive element (TRE3G), respectively. Cell-cell fusion by the transient transfection of viral fusogens in the presence of doxycycline results in the expression of the reporter enzyme secreted alkaline phosphatase (SEAP) and the fluorescent nuclear localization marker EYFPNuc. A constitutively expressed, secreted form of nanoluciferase (secNLuc) functioned as the internal control. The performance of the SRFIA was tested for the quantification of SARS-CoV-2- and HSV-1-induced cell-cell fusion, respectively, showing high sensitivity and specificity, as well as the reliable identification of known fusion inhibitors. Parallel quantification of secNLuc enabled the detection of cytotoxic compounds or insufficient transfection efficacy. In conclusion, the SRFIA reported here is well suited for high-throughput screening for new antiviral agents and essentially will be applicable to all viral fusogens causing cell-cell fusion in Vero cells.", "doi": "10.3390/v14071354", "pmid": "35891336", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "v14071354"}, {"db": "pmc", "key": "PMC9322530"}], "notes": [], "created": "2022-08-12T08:35:12.802Z", "modified": "2022-08-12T08:35:12.933Z"}, {"entity": "publication", "iuid": "0f95ab7453574fc49096b75980416597", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0f95ab7453574fc49096b75980416597.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0f95ab7453574fc49096b75980416597"}}, "title": "[Swedish gallstone surgery during the covid-19 pandemic].", "authors": [{"family": "Johan Drott", "given": "Carl", "initials": "C"}, {"family": "Sandblom", "given": "Gabriel", "initials": "G"}, {"family": "\u00d6sterberg", "given": "Johanna", "initials": "J"}, {"family": "Rogmark", "given": "Peder", "initials": "P"}, {"family": "Enochsson", "given": "Lars", "initials": "L"}], "type": "journal article", "published": "2022-06-20", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "volume": "119", "issn-l": "0023-7205"}, "abstract": "The covid-19 pandemic has necessitated reallocation of health care resources. This has raised concerns about the risks associated with postponing surgery for benign conditions that are given low priority. Data from the population-based Swedish National Register for Gallstone Surgery (GallRiks) show that the total number of procedures carried out during the initial months of each wave of the pandemic decreased. This was followed by a moderate increase in the number of procedures performed for acute cholecystitis, biliary pancreatitis, and obstructive jaundice. The consequences of the delayed surgery in the community at large and how this has affected health-related quality of life for patients having their procedure postponed remain to be evaluated, but so far it does not seem to have caused a major impact on public health.", "doi": null, "pmid": "35723571", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "21230"}], "notes": [], "created": "2022-08-17T12:44:12.527Z", "modified": "2022-08-17T12:44:12.540Z"}, {"entity": "publication", "iuid": "5b26867b6a75453abaea1cabf66361a3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5b26867b6a75453abaea1cabf66361a3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5b26867b6a75453abaea1cabf66361a3"}}, "title": "SARS-CoV-2 Specific Antibody Response and T Cell-Immunity in Immunocompromised Patients up to Six Months Post COVID: A Pilot Study.", "authors": [{"family": "Sj\u00f6wall", "given": "Johanna", "initials": "J", "orcid": "0000-0001-5622-866X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/352c62c6701e4bb89b3029d38803b9be.json"}}, {"family": "Hjorth", "given": "Maria", "initials": "M", "orcid": "0000-0002-4195-9387", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ccf79a5f280460aa963ce38b97bc5d7.json"}}, {"family": "Gustafsson", "given": "Annette", "initials": "A"}, {"family": "G\u00f6ransson", "given": "Robin", "initials": "R"}, {"family": "Larsson", "given": "Marie", "initials": "M", "orcid": "0000-0002-4524-0177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8d3f27eebb4456f965bc4da2c99176f.json"}}, {"family": "Waller", "given": "Hjalmar", "initials": "H"}, {"family": "Nordgren", "given": "Johan", "initials": "J", "orcid": "0000-0002-5349-2569", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad771e6e329b4442b045d31dddfdd8ec.json"}}, {"family": "Nilsdotter-Augustinsson", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0001-5719-5601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c315dcd94fd427ea248f6502de0229a.json"}}, {"family": "Nystr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0002-0145-4966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56bc7bc8ab444c81afd336394ae7607d.json"}}], "type": "journal article", "published": "2022-06-20", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "11", "issue": "12", "issn-l": "2077-0383"}, "abstract": "COVID-19 generates SARS-CoV-2-specific antibodies in immunocompetent individuals. However, in immunocompromised patients, the humoral immunity following infection may be impaired or absent. Recently, the assessment of cellular immunity to SARS-CoV-2, both following natural infection and vaccination, has contributed new knowledge regarding patients with low or no antibody responses. As part of a prospective cohort study which included hospitalized patients with COVID-19, we identified immunocompromised patients and compared them with age- and sex-matched immunocompetent patients regarding co-morbidities, biomarkers of COVID-19 and baseline viral load by real-time PCR in nasopharyngeal swabs. Spike and nucleocapsid antibody responses were analyzed at inclusion and after two weeks, six weeks and six months. Plasma immunoglobulin G (IgG) levels were quantified, lymphocyte phenotyping was performed, and SARS-CoV-2 specific CD4 and CD8 T cell responses after in vitro antigen stimulation were assessed at six months post infection. All patients showed IgG levels above or within reference limits. At six months, all patients had detectable SARS-CoV-2 anti-spike antibody levels. SARS-CoV-2 specific T cell responses were detected in 12 of 12 immunocompetent patients and in four of six immunocompromised patients. The magnitude of long-lived SARS-CoV-2 specific T cell responses were significantly correlated with the number of CD4 T cells and NK cells. Determining the durability of the humoral and cellular immune response against SARS-CoV-2 in immunocompromised individuals could be of importance by providing insights into the risk of re-infection and the need for vaccine boosters.", "doi": "10.3390/jcm11123535", "pmid": "35743605", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "jcm11123535"}, {"db": "pmc", "key": "PMC9225567"}], "notes": [], "created": "2022-08-19T05:44:04.368Z", "modified": "2022-08-19T05:44:22.039Z"}, {"entity": "publication", "iuid": "56677e17fc034e98afcf2e59f69e1242", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56677e17fc034e98afcf2e59f69e1242.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56677e17fc034e98afcf2e59f69e1242"}}, "title": "Integrating the CARD (Comfort Ask Relax Distract) system in a mass vaccination clinic to improve the experience of individuals during COVID-19 vaccination: a pre-post implementation study.", "authors": [{"family": "Tetui", "given": "Moses", "initials": "M"}, {"family": "Grindrod", "given": "Kelly", "initials": "K"}, {"family": "Waite", "given": "Nancy", "initials": "N"}, {"family": "VanderDoes", "given": "Jeremy", "initials": "J"}, {"family": "Taddio", "given": "Anna", "initials": "A", "orcid": "0000-0003-4432-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/383c983259be4b55b13c682f9d2a34bb.json"}}], "type": "journal article", "published": "2022-06-20", "journal": {"title": "Hum Vaccin Immunother", "issn": "2164-554X", "pages": "2089500", "issn-l": null}, "abstract": "Many people have negative experiences with vaccination due to stress-related reactions including fear and pain. We used a pre-post study design to evaluate the impact of implementing a modified version of the CARD (Comfort-Ask-Relax-Distract) system on stress-related reactions in individuals aged 12 y or older undergoing COVID-19 vaccinations in mass vaccination clinics. Vaccine recipients reported their level of pain, fear and dizziness during vaccination. Clinic staff reported their attitudes about CARD and use of CARD interventions. CARD improved client symptoms across genders and ages with an average reduction in needle pain, fear and dizziness of 75%, 40% and 44%, respectively. CARD was more effective in younger individuals. Clinic staff reported positive attitudes about CARD and uptake of selected CARD interventions. In summary, the modified CARD system reduced stress-related responses in a general population undergoing COVID-19 vaccinations in a mass vaccination clinic, was feasible and acceptable to staff. Future implementation efforts are recommended that include more diverse cultural contexts and incorporate education of individuals about CARD ahead of time.", "doi": "10.1080/21645515.2022.2089500", "pmid": "35723609", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-20T18:02:30.194Z", "modified": "2022-08-17T12:43:56.064Z"}, {"entity": "publication", "iuid": "c70af74a320e4b07ab68d297de9790b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c70af74a320e4b07ab68d297de9790b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c70af74a320e4b07ab68d297de9790b4"}}, "title": "Increase in admission rates and symptom severity of childhood and adolescent anorexia nervosa in Europe during the COVID-19 pandemic: data from specialized eating disorder units in different European countries.", "authors": [{"family": "Gilsbach", "given": "Susanne", "initials": "S"}, {"family": "Plana", "given": "Maria Teresa", "initials": "MT"}, {"family": "Castro-Fornieles", "given": "Josefina", "initials": "J"}, {"family": "Gatta", "given": "Michela", "initials": "M"}, {"family": "Karlsson", "given": "Gunilla Paulson", "initials": "GP"}, {"family": "Flamarique", "given": "Itziar", "initials": "I"}, {"family": "Raynaud", "given": "Jean-Philippe", "initials": "JP"}, {"family": "Riva", "given": "Anna", "initials": "A"}, {"family": "Solberg", "given": "Anne-Line", "initials": "AL"}, {"family": "van Elburg", "given": "Annemarie A", "initials": "AA"}, {"family": "Wentz", "given": "Elisabet", "initials": "E"}, {"family": "Nacinovich", "given": "Renata", "initials": "R"}, {"family": "Herpertz-Dahlmann", "given": "Beate", "initials": "B"}], "type": "journal article", "published": "2022-06-20", "journal": {"title": "Child Adolesc Psychiatry Ment Health", "issn": "1753-2000", "volume": "16", "issue": "1", "pages": "46", "issn-l": null}, "abstract": "The COVID-19 pandemic, associated with confinement and social isolation, seems to have impacted the course of many mental disorders in children and adolescents. An increase in hospital admission rates for juvenile anorexia nervosa (AN) has been documented in many regions of the world. However, data from Europe are scarce.\n\nWe asked clinicians in specialized eating disorder units in hospitals of maximum care in France, Germany, Italy, Spain, Sweden, and the Netherlands to report on (i) overall (inpatient and outpatient) and (ii) inpatient admission rates for adolescents with AN during 2019 and 2020. Additionally, a modified version of the COVID Isolation Eating Scale (CIES) was used to assess the child and adolescent psychiatrists' estimations of a possible increase in symptom severity in children and adolescents with AN during the COVID-19 pandemic and to (iii) inquire about the contributing factors perceived by the caring professionals.\n\nFour out of six representatives of European hospitals described a higher rate of overall admissions during the pandemic. Three hospitals out of six reported an increase in inpatient admissions, and two centres had constant high numbers of admissions of both outpatients and inpatients. The clinicians perceived a higher symptom severity in 2020 than in 2019, especially involving more frequent use of social media, longer duration of exercising, and more restrictive eating. They supposed an increase in social media consumption, a perceived \"loss of control\", and a lack of in-person assessments and weight controls as the main contributing factors for the deterioration in AN numbers and symptomatology.\n\nThe COVID-19 pandemic seems to have had a deep impact on symptom severity in AN, which is mirrored by a large increase in admission rates across Europe. An increase in exercise, social media consumption, a perceived \"loss of control\", and a lack of face-to-face health care seem to have contributed to this development. Further investigation is required to identify which factors may lead to the increase in incidence and deterioration of childhood and adolescent AN. Possible preventive means for the future could include educating paediatricians and health care workers about AN, regular weight assessment, and home-based treatments.", "doi": "10.1186/s13034-022-00482-x", "pmid": "35725621", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13034-022-00482-x"}, {"db": "pmc", "key": "PMC9208345"}], "notes": [], "created": "2022-08-17T13:04:58.818Z", "modified": "2022-08-17T13:04:58.831Z"}, {"entity": "publication", "iuid": "fa8fe4b9a71a4f3390db169213dcc235", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa8fe4b9a71a4f3390db169213dcc235.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa8fe4b9a71a4f3390db169213dcc235"}}, "title": "COVID-19 conspiracy ideation is associated with the delusion proneness trait and resistance to update of beliefs.", "authors": [{"family": "Acar", "given": "K", "initials": "K"}, {"family": "Horntvedt", "given": "O", "initials": "O"}, {"family": "Cabrera", "given": "A", "initials": "A"}, {"family": "Olsson", "given": "A", "initials": "A"}, {"family": "Ingvar", "given": "M", "initials": "M"}, {"family": "Lebedev", "given": "A V", "initials": "AV"}, {"family": "Petrovic", "given": "P", "initials": "P"}], "type": "journal article", "published": "2022-06-20", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "10352", "issn-l": "2045-2322"}, "abstract": "The rapid spread of conspiracy ideas associated with the recent COVID-19 pandemic represents a major threat to the ongoing and coming vaccination programs. Yet, the cognitive factors underlying the pandemic-related conspiracy beliefs are not well described. We hypothesized that such cognitive style is driven by delusion proneness, a trait phenotype associated with formation of delusion-like beliefs that exists on a continuum in the normal population. To probe this hypothesis, we developed a COVID-19 conspiracy questionnaire (CCQ) and assessed 577 subjects online. Their responses clustered into three factors that included Conspiracy, Distrust and Fear/Action as identified using principal component analysis. We then showed that CCQ (in particular the Conspiracy and Distrust factors) related both to general delusion proneness assessed with Peter's Delusion Inventory (PDI) as well as resistance to belief update using a Bias Against Disconfirmatory Evidence (BADE) task. Further, linear regression and pathway analyses suggested a specific contribution of BADE to CCQ not directly explained by PDI. Importantly, the main results remained significant when using a truncated version of the PDI where questions on paranoia were removed (in order to avoid circular evidence), and when adjusting for ADHD- and autistic traits (that are known to be substantially related to delusion proneness). Altogether, our results strongly suggest that pandemic-related conspiracy ideation is associated with delusion proneness trait phenotype.", "doi": "10.1038/s41598-022-14071-7", "pmid": "35725585", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-14071-7"}, {"db": "pmc", "key": "PMC9208343"}], "notes": [], "created": "2022-08-17T13:04:41.886Z", "modified": "2022-08-17T13:04:41.892Z"}, {"entity": "publication", "iuid": "ef5e6ee82251415ab0690481ddfaf624", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef5e6ee82251415ab0690481ddfaf624.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef5e6ee82251415ab0690481ddfaf624"}}, "title": "Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir.", "authors": [{"family": "Jemth", "given": "Ann-Sofie", "initials": "AS"}, {"family": "Scaletti", "given": "Emma Rose", "initials": "ER"}, {"family": "Homan", "given": "Evert", "initials": "E"}, {"family": "Stenmark", "given": "P\u00e5l", "initials": "P"}, {"family": "Helleday", "given": "Thomas", "initials": "T"}, {"family": "Michel", "given": "Maurice", "initials": "M"}], "type": "journal article", "published": "2022-06-19", "journal": {"title": "J Biol Chem", "issn": "1083-351X", "volume": "298", "issue": "8", "pages": "102169", "issn-l": "0021-9258"}, "abstract": "Remdesivir and molnupiravir have gained considerable interest because of their demonstrated activity against SARS-CoV-2. These antivirals are converted intracellularly to their active triphosphate forms remdesivir-TP and molnupiravir-TP. Cellular hydrolysis of these active metabolites would consequently decrease the efficiency of these drugs; however, whether endogenous enzymes that can catalyze this hydrolysis exist is unknown. Here, we tested remdesivir-TP as a substrate against a panel of human hydrolases and found that only Nudix hydrolase (NUDT) 18 catalyzed the hydrolysis of remdesivir-TP with notable activity. The kcat/Km value of NUDT18 for remdesivir-TP was determined to be 17,700 s-1M-1, suggesting that NUDT18-catalyzed hydrolysis of remdesivir-TP may occur in cells. Moreover, we demonstrate that the triphosphates of the antivirals ribavirin and molnupiravir are also hydrolyzed by NUDT18, albeit with lower efficiency than Remdesivir-TP. Low activity was also observed with the triphosphate forms of sofosbuvir and aciclovir. This is the first report showing that NUDT18 hydrolyzes triphosphates of nucleoside analogs of exogenous origin, suggesting that NUDT18 can act as a cellular sanitizer of modified nucleotides and may influence the antiviral efficacy of remdesivir, molnupiravir, and ribavirin. As NUDT18 is expressed in respiratory epithelial cells, it may limit the antiviral efficacy of remdesivir and molnupiravir against SARS-CoV-2 replication by decreasing the intracellular concentration of their active metabolites at their intended site of action.", "doi": "10.1016/j.jbc.2022.102169", "pmid": "35732208", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0021-9258(22)00611-1"}, {"db": "pmc", "key": "PMC9212496"}], "notes": [], "created": "2022-08-19T05:52:40.420Z", "modified": "2022-08-19T05:52:40.432Z"}, {"entity": "publication", "iuid": "f81a5edc998b42078e254d2da59c4dc0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f81a5edc998b42078e254d2da59c4dc0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f81a5edc998b42078e254d2da59c4dc0"}}, "title": "Sensitization-Associated Post-COVID-19 Symptoms at 6 Months Are Not Associated with Serological Biomarkers at Hospital Admission in COVID-19 Survivors: A Secondary Analysis of a Cohort Study.", "authors": [{"family": "Fern\u00e1ndez-de-Las-Pe\u00f1as", "given": "C\u00e9sar", "initials": "C", "orcid": "0000-0003-3772-9690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f64421a4c1b343f1a1bc17e02236f386.json"}}, {"family": "Herrero-Montes", "given": "Manuel", "initials": "M", "orcid": "0000-0002-5732-8344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3460d36201934582b42366a9e2e736c0.json"}}, {"family": "Ferrer-Pargada", "given": "Diego", "initials": "D"}, {"family": "Izquierdo-Cuervo", "given": "Sheila", "initials": "S"}, {"family": "Arendt-Nielsen", "given": "Lars", "initials": "L", "orcid": "0000-0003-0892-1579", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d147964e28949a49f9572be5317fc04.json"}}, {"family": "Nijs", "given": "Jo", "initials": "J", "orcid": "0000-0002-4976-6563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4c1747ed07f4ef6a09c589a4a9c9f2d.json"}}, {"family": "Par\u00e1s-Bravo", "given": "Paula", "initials": "P", "orcid": "0000-0001-7745-3006", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef0603c7d86b4098b44cfb4aeea8785f.json"}}], "type": "journal article", "published": "2022-06-18", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "11", "issue": "12", "issn-l": "2077-0383"}, "abstract": "Individuals who survived coronavirus disease, 2019 (COVID-19), often have symptoms of sensitization, but the extent to which these symptoms relate to serological biomarkers remains unclear. Therefore, this secondary analysis evaluated the association between serological biomarkers at hospital admission with sensitization-associated post-COVID-19 symptoms in a sample of previously hospitalized COVID-19 survivors. Sixty-seven individuals hospitalized due to SARS-CoV-2 infection in one urban hospital of Madrid (Spain) during the first wave of the pandemic were assessed a mean of 6.0 (SD 0.8) months after hospital discharge. The Central Sensitization Inventory (CSI) was used as rough tool to estimate the presence of sensitization-associated post-COVID-19 symptoms (\u226540/100 points). Levels of 16 serological biomarkers collected at hospital admission were obtained from medical records. Twenty-four (35.8%) patients reported sensitization-associated post-COVID-19 symptoms (CSI \u2265 40 points). Subjects reporting sensitization-associated symptoms had lower ferritin and hemoglobin levels than those not reporting sensitization-associated post-COVID-19 symptoms; however, these differences were small. We observed significant but small negative associations of the CSI score with ferritin (r: -0.251, p = 0.04) and hemoglobin (r: -0.292, p = 0.017) levels. No other significant difference was found. In conclusion, this secondary analysis did not find significant associations between the investigated serological biomarkers at hospital admission and sensitization-associated post-COVID-19 symptoms at 6 months after hospitalization in COVID-19 survivors.", "doi": "10.3390/jcm11123512", "pmid": "35743582", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "jcm11123512"}, {"db": "pmc", "key": "PMC9225549"}], "notes": [], "created": "2022-08-19T05:44:48.081Z", "modified": "2022-08-19T05:44:48.243Z"}, {"entity": "publication", "iuid": "348b1fa1816746bf9c15e7c4861df2ce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/348b1fa1816746bf9c15e7c4861df2ce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/348b1fa1816746bf9c15e7c4861df2ce"}}, "title": "Healthcare Professionals' Experience of Performing Digital Care Visits-A Scoping Review.", "authors": [{"family": "Lampickien\u0117", "given": "Ieva", "initials": "I"}, {"family": "Davoody", "given": "Nadia", "initials": "N", "orcid": "0000-0003-1813-8529", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/842dc06d06834029b4621c61a2623667.json"}}], "type": "journal article", "published": "2022-06-17", "journal": {"title": "Life (Basel)", "issn": "2075-1729", "volume": "12", "issue": "6", "issn-l": null}, "abstract": "The use of digital care visits has been increasing during the COVID-19 pandemic. Learning more about healthcare professionals' technology experiences provides valuable insight and a basis for improving digital visits. This study aimed to explore the existing literature on healthcare professionals' experience performing digital care visits. A scoping review was performed following Arksey & O'Malley's proposed framework using the Preferred Reporting Items for Systematic reviews and Meta-Analyses. The collected data were analyzed using thematic content analysis. Five main themes were identified in the literature: positive experiences/benefits, facilitators, negative experiences/challenges, barriers, and suggestions for improvement. Healthcare professionals mostly reported having an overall positive experience with digital visits and discovered benefits for themselves and the patients. However, opinions were mixed or negative regarding the complexity of decision making, workload and workflow, suitability of this type of care, and other challenges. The suggestions for improvement included training and education, improvements within the system and tools, along with support for professionals. Despite overall positive experiences and benefits for both professionals and patients, clinicians reported challenges such as physical barriers, technical issues, suitability concerns, and others. Digital care visits could not fully replace face-to-face visits.", "doi": "10.3390/life12060913", "pmid": "35743944", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "life12060913"}, {"db": "pmc", "key": "PMC9225275"}], "notes": [], "created": "2022-08-19T05:43:44.038Z", "modified": "2022-08-19T05:43:44.094Z"}, {"entity": "publication", "iuid": "983f426f18fc4baea38dc85d6d68cc0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/983f426f18fc4baea38dc85d6d68cc0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/983f426f18fc4baea38dc85d6d68cc0e"}}, "title": "COVID-19 vaccination-related adverse events among autoimmune disease patients: results from the COVAD study.", "authors": [{"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "R", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Kardes", "given": "Sinan", "initials": "S", "orcid": "0000-0002-6311-8634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2900c3ca00da476a8914574384a3c9c2.json"}}, {"family": "Kim", "given": "Minchul", "initials": "M", "orcid": "0000-0001-9737-6255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd2952c6167b4733bfbce019a162b310.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "O'Callaghan", "given": "Albert Selva", "initials": "AS", "orcid": "0000-0003-2823-9761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef3e202c049b44a2a5e045bac90a393a.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "COVAD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-06-17", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "issn-l": null}, "abstract": "COVID-19 vaccines have been proven to be safe in the healthy population. However, gaps remain in the evidence of their safety in patients with systemic autoimmune and inflammatory disorders (SAIDs). COVID-19 vaccination related adverse events (ADEs) in patients with SAIDs and healthy controls (HC) seven days post-vaccination were assessed in the COVAD study, a patient self-reported cross-sectional survey.\n\nThe survey was circulated in early 2021 by > 110 collaborators (94 countries) to collect SAID details, COVID-19 vaccination details, and 7-day vaccine ADEs, irrespective of respondent vaccination status. Analysis was performed based on data distribution and variable type.\n\n10900 respondents [42 (30-55) years, 74% females and 45% Caucasians] were analyzed. 5,867 patients (54%) with SAIDs were compared with 5033 HCs.79% had minor and only 3% had major vaccine ADEs requiring urgent medical attention (but not hospital admission) overall. Headache [SAIDs=26%, HCs=24%; OR = 1.1 (1.03-1.3); p = 0.014], abdominal pain [SAIDs=2.6%, HCs=1.4%; OR = 1.5 (1.1-2.3); p = 0.011], and dizziness [SAIDs=6%, HCs=4%; OR = 1.3 (1.07-1.6); p = 0.011], were slightly more frequent in SAIDs. Overall, major ADEs [SAIDs=4%, HCs=2%; OR = 1.9 (1.6-2.2); p < 0.001] and, specifically, throat closure [SAIDs=0.5%, HCs=0.3%; OR = 5.7 (2.9-11); p = 0.010] were more frequent in SAIDs though absolute risk was small (0-4%). Major ADEs and hospitalizations (less than 2%) were comparable across vaccine types in SAIDs.\n\nVaccination against COVID-19 is relatively safe in SAID patients. SAIDs were at a higher risk of major ADEs than HCs, though absolute risk was small. There are small differences in minor ADEs between vaccine types in SAID patients.", "doi": "10.1093/rheumatology/keac305", "pmid": "35713499", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6609762"}, {"db": "pmc", "key": "PMC9214139"}], "notes": [], "created": "2022-06-20T18:06:19.191Z", "modified": "2022-08-17T12:47:13.086Z"}, {"entity": "publication", "iuid": "556f775a8812436895594f18d49067f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/556f775a8812436895594f18d49067f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/556f775a8812436895594f18d49067f8"}}, "title": "Public anxiety through various stages of COVID-19 coping: Evidence from China.", "authors": [{"family": "Wu", "given": "Yangyang", "initials": "Y"}, {"family": "Zhang", "given": "Ting", "initials": "T"}, {"family": "Ye", "given": "Ziwen", "initials": "Z"}, {"family": "Chen", "given": "Kai", "initials": "K"}, {"family": "Kuijp", "given": "J van der", "initials": "JV"}, {"family": "Sun", "given": "Xue", "initials": "X"}, {"family": "Han", "given": "Guoyi", "initials": "G"}, {"family": "Zhao", "given": "Yi", "initials": "Y"}, {"family": "Liu", "given": "Yang", "initials": "Y", "orcid": "0000-0001-5477-2186", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43230a960dd84a27ba4777fcd2a0f189.json"}}, {"family": "Huang", "given": "Lei", "initials": "L", "orcid": "0000-0002-9279-878X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5bad866d23b4fd3902a7214f88f5484.json"}}], "type": "journal article", "published": "2022-06-16", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "6", "pages": "e0270229", "issn-l": "1932-6203"}, "abstract": "As countries underwent the initiation, peak, post-peak, and early vaccination stages of COVID-19, the changing risk perception, coping behaviors and corresponding psychological stress experienced by the public over time was rarely reported. We conducted a national scale panel study using social-psychological data collected from 5,983 questionnaires to investigate the interactions between anxiety level, risk perception and coping behavior during different stages of COVID-19 in China. We found that sustained perceiving worries of being infected, first due to domestic and then global pandemic, contributed to the persistent high proportion of respondents with anxiety disorders which even gradually increased over time (56.1% during initiation to 60.4% during early vaccination). Gender was the strongest predictor of anxiety at all stages, with females having less confidence in COVID-19 control and always suffering from much higher anxiety levels than males even during the post peak stage. Excessive protective behavior and frequency of access to COVID-related news also contributed to public anxiety. Additionally, public risk perception was significantly associated with their willingness to vaccinate. The findings verify the feasibility of taking stage-specific and gender-based risk communication strategies to alleviate the pandemic-related public anxiety and promote vaccination by influencing public risk perception and guiding coping behaviors.", "doi": "10.1371/journal.pone.0270229", "pmid": "35709292", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-22-05358"}, {"db": "pmc", "key": "PMC9202924"}], "notes": [], "created": "2022-06-20T18:07:18.211Z", "modified": "2022-08-17T12:47:43.967Z"}, {"entity": "publication", "iuid": "6c7c15fd98be42c6bff33bc2dd174b0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c7c15fd98be42c6bff33bc2dd174b0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c7c15fd98be42c6bff33bc2dd174b0e"}}, "title": "Novel genes and sex differences in COVID-19 severity.", "authors": [{"family": "Cruz", "given": "Raquel", "initials": "R", "orcid": "0000-0002-6964-8898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5697ffeaef2b40b584dc400b00544e76.json"}}, {"family": "Almeida", "given": "Silvia Diz-de", "initials": "SD"}, {"family": "Heredia", "given": "Miguel L\u00f3pez", "initials": "ML"}, {"family": "Quintela", "given": "In\u00e9s", "initials": "I"}, {"family": "Ceballos", "given": "Francisco C", "initials": "FC"}, {"family": "Pita", "given": "Guillermo", "initials": "G"}, {"family": "Lorenzo-Salazar", "given": "Jos\u00e9 M", "initials": "JM"}, {"family": "Gonz\u00e1lez-Montelongo", "given": "Rafaela", "initials": "R"}, {"family": "Gago-Dom\u00ednguez", "given": "Manuela", "initials": "M"}, {"family": "Porras", "given": "Marta Sevilla", "initials": "MS"}, {"family": "Casta\u00f1o", "given": "Jair Antonio Tenorio", "initials": "JAT"}, {"family": "Nevado", "given": "Julian", "initials": "J"}, {"family": "Aguado", "given": "Jose Mar\u00eda", "initials": "JM"}, {"family": "Aguilar", "given": "Carlos", "initials": "C"}, {"family": "Aguilera-Albesa", "given": "Sergio", "initials": "S"}, {"family": "Almadana", "given": "Virginia", "initials": "V"}, {"family": "Almoguera", "given": "Berta", "initials": "B"}, {"family": "Alvarez", "given": "Nuria", "initials": "N"}, {"family": "Andreu-Bernabeu", "given": "\u00c1lvaro", "initials": "\u00c1"}, {"family": "Arana-Arri", "given": "Eunate", "initials": "E"}, {"family": "Arango", "given": "Celso", "initials": "C"}, {"family": "Arranz", "given": "Mar\u00eda J", "initials": "MJ"}, {"family": "Artiga", "given": "Maria-Jesus", "initials": "MJ"}, {"family": "Baptista-Rosas", "given": "Ra\u00fal C", "initials": "RC"}, {"family": "Barreda-S\u00e1nchez", "given": "Mar\u00eda", "initials": "M"}, {"family": "Belhassen-Garcia", "given": "Moncef", "initials": "M"}, {"family": "Bezerra", "given": "Joao F", "initials": "JF"}, {"family": "Bezerra", "given": "Marcos A C", "initials": "MAC"}, {"family": "Boix-Palop", "given": "Luc\u00eda", "initials": "L"}, {"family": "Brion", "given": "Mar\u00eda", "initials": "M", "orcid": "0000-0001-7463-2148", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cd3234359d94481abd8238f3c3086cc.json"}}, {"family": "Brugada", "given": "Ram\u00f3n", "initials": "R"}, {"family": "Bustos", "given": "Matilde", "initials": "M"}, {"family": "Calder\u00f3n", "given": "Enrique J", "initials": "EJ", "orcid": "0000-0002-3166-5086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ec00f43e1fb43c6b754a31cbe723bbf.json"}}, {"family": "Carbonell", "given": "Cristina", "initials": "C"}, {"family": "Castano", "given": "Luis", "initials": "L"}, {"family": "Castelao", "given": "Jose E", "initials": "JE"}, {"family": "Conde-Vicente", "given": "Rosa", "initials": "R"}, {"family": "Cordero-Lorenzana", "given": "M Lourdes", "initials": "ML"}, {"family": "Cortes-Sanchez", "given": "Jose L", "initials": "JL"}, {"family": "Corton", "given": "Marta", "initials": "M"}, {"family": "Darnaude", "given": "M Teresa", "initials": "MT"}, {"family": "De Martino-Rodr\u00edguez", "given": "Alba", "initials": "A"}, {"family": "Campo-P\u00e9rez", "given": "Victor", "initials": "V"}, {"family": "Bustamante", "given": "Aranzazu Diaz", "initials": "AD"}, {"family": "Dom\u00ednguez-Garrido", "given": "Elena", "initials": "E"}, {"family": "Luchessi", "given": "Andre D", "initials": "AD"}, {"family": "Eir\u00f3s", "given": "Roc\u00edo", "initials": "R"}, {"family": "Sanabria", "given": "Gladys Mercedes Estigarribia", "initials": "GME"}, {"family": "Fari\u00f1as", "given": "Mar\u00eda Carmen", "initials": "MC"}, {"family": "Fern\u00e1ndez-Robelo", "given": "Ux\u00eda", "initials": "U"}, {"family": "Fern\u00e1ndez-Rodr\u00edguez", "given": "Amanda", "initials": "A"}, {"family": "Fern\u00e1ndez-Villa", "given": "Tania", "initials": "T"}, {"family": "Gil-Fournier", "given": "Bel\u00e9n", "initials": "B"}, {"family": "G\u00f3mez-Arrue", "given": "Javier", "initials": "J"}, {"family": "\u00c1lvarez", "given": "Beatriz Gonz\u00e1lez", "initials": "BG"}, {"family": "Quir\u00f3s", "given": "Fernan Gonzalez Bernaldo", "initials": "FGB"}, {"family": "Gonz\u00e1lez-Pe\u00f1as", "given": "Javier", "initials": "J"}, {"family": "Guti\u00e9rrez-Bautista", "given": "Juan F", "initials": "JF", "orcid": "0000-0003-1374-0756", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a426ebb240a54f0ab776e410f9244b70.json"}}, {"family": "Herrero", "given": "Mar\u00eda Jos\u00e9", "initials": "MJ"}, {"family": "Herrero-Gonzalez", "given": "Antonio", "initials": "A"}, {"family": "Jimenez-Sousa", "given": "Mar\u00eda A", "initials": "MA"}, {"family": "Lattig", "given": "Mar\u00eda Claudia", "initials": "MC"}, {"family": "Borja", "given": "Anabel Liger", "initials": "AL"}, {"family": "Lopez-Rodriguez", "given": "Rosario", "initials": "R"}, {"family": "Mancebo", "given": "Esther", "initials": "E"}, {"family": "Mart\u00edn-L\u00f3pez", "given": "Caridad", "initials": "C"}, {"family": "Mart\u00edn", "given": "Vicente", "initials": "V"}, {"family": "Martinez-Nieto", "given": "Oscar", "initials": "O"}, {"family": "Martinez-Lopez", "given": "Iciar", "initials": "I"}, {"family": "Martinez-Resendez", "given": "Michel F", "initials": "MF"}, {"family": "Martinez-Perez", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "Mazzeu", "given": "Juliana A", "initials": "JA"}, {"family": "Mac\u00edas", "given": "Eleuterio Merayo", "initials": "EM"}, {"family": "Minguez", "given": "Pablo", "initials": "P"}, {"family": "Cuerda", "given": "Victor Moreno", "initials": "VM"}, {"family": "Silbiger", "given": "Vivian N", "initials": "VN"}, {"family": "Oliveira", "given": "Silviene F", "initials": "SF"}, {"family": "Ortega-Paino", "given": "Eva", "initials": "E"}, {"family": "Parellada", "given": "Mara", "initials": "M"}, {"family": "Paz-Artal", "given": "Estela", "initials": "E"}, {"family": "Santos", "given": "Ney P C", "initials": "NPC"}, {"family": "P\u00e9rez-Matute", "given": "Patricia", "initials": "P"}, {"family": "Perez", "given": "Patricia", "initials": "P"}, {"family": "P\u00e9rez-Tom\u00e1s", "given": "M Elena", "initials": "ME"}, {"family": "Perucho", "given": "Teresa", "initials": "T"}, {"family": "Pinsach-Abuin", "given": "Mel Lina", "initials": "ML"}, {"family": "Pompa-Mera", "given": "Ericka N", "initials": "EN"}, {"family": "Porras-Hurtado", "given": "Gloria L", "initials": "GL"}, {"family": "Pujol", "given": "Aurora", "initials": "A"}, {"family": "Le\u00f3n", "given": "Soraya Ramiro", "initials": "SR"}, {"family": "Resino", "given": "Salvador", "initials": "S"}, {"family": "Fernandes", "given": "Marianne R", "initials": "MR"}, {"family": "Rodr\u00edguez-Ruiz", "given": "Emilio", "initials": "E"}, {"family": "Rodriguez-Artalejo", "given": "Fernando", "initials": "F"}, {"family": "Rodriguez-Garcia", "given": "Jos\u00e9 A", "initials": "JA"}, {"family": "Ruiz-Cabello", "given": "Francisco", "initials": "F"}, {"family": "Ruiz-Hornillos", "given": "Javier", "initials": "J"}, {"family": "Ryan", "given": "Pablo", "initials": "P"}, {"family": "Soria", "given": "Jos\u00e9 Manuel", "initials": "JM"}, {"family": "Souto", "given": "Juan Carlos", "initials": "JC"}, {"family": "Tamayo", "given": "Eduardo", "initials": "E"}, {"family": "Tamayo-Velasco", "given": "Alvaro", "initials": "A"}, {"family": "Taracido-Fernandez", "given": "Juan Carlos", "initials": "JC"}, {"family": "Teper", "given": "Alejandro", "initials": "A"}, {"family": "Torres-Tobar", "given": "Lilian", "initials": "L"}, {"family": "Urioste", "given": "Miguel", "initials": "M"}, {"family": "Valencia-Ramos", "given": "Juan", "initials": "J"}, {"family": "Y\u00e1\u00f1ez", "given": "Zuleima", "initials": "Z"}, {"family": "Zarate", "given": "Ruth", "initials": "R"}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T", "orcid": "0000-0001-9510-5646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd273e50091d44c3b3e8d1473ce89b0a.json"}}, {"family": "Pigazzini", "given": "Sara", "initials": "S"}, {"family": "Degenhardt", "given": "Frauke", "initials": "F", "orcid": "0000-0001-7516-3179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab8dc6a0eb504f41a89c140d68b87b6a.json"}}, {"family": "Butler-Laporte", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-5388-0396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/529dc69151d3463e8480b975d70fa759.json"}}, {"family": "Maya-Miles", "given": "Douglas", "initials": "D"}, {"family": "Bujanda", "given": "Luis", "initials": "L"}, {"family": "Bouysran", "given": "Youssef", "initials": "Y"}, {"family": "Palom", "given": "Adriana", "initials": "A"}, {"family": "Ellinghaus", "given": "David", "initials": "D"}, {"family": "Mart\u00ednez-Bueno", "given": "Manuel", "initials": "M"}, {"family": "Rolker", "given": "Selina", "initials": "S"}, {"family": "Amitrano", "given": "Sara", "initials": "S"}, {"family": "Roade", "given": "Luisa", "initials": "L"}, {"family": "Fava", "given": "Francesca", "initials": "F"}, {"family": "Spinner", "given": "Christoph D", "initials": "CD", "orcid": "0000-0002-3875-5367", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c506eb763b34155bbc6187f4ccb5f62.json"}}, {"family": "Prati", "given": "Daniele", "initials": "D"}, {"family": "Bernardo", "given": "David", "initials": "D"}, {"family": "Garcia", "given": "Federico", "initials": "F"}, {"family": "Darcis", "given": "Gilles", "initials": "G"}, {"family": "Fern\u00e1ndez-Cadenas", "given": "Israel", "initials": "I"}, {"family": "Holter", "given": "Jan Cato", "initials": "JC"}, {"family": "Banales", "given": "Jesus M", "initials": "JM"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Duga", "given": "Stefano", "initials": "S"}, {"family": "Asselta", "given": "Rosanna", "initials": "R"}, {"family": "Pereira", "given": "Alexandre C", "initials": "AC"}, {"family": "Romero-G\u00f3mez", "given": "Manuel", "initials": "M"}, {"family": "Nafr\u00eda-Jim\u00e9nez", "given": "Beatriz", "initials": "B"}, {"family": "Hov", "given": "Johannes R", "initials": "JR"}, {"family": "Migeotte", "given": "Isabelle", "initials": "I"}, {"family": "Renieri", "given": "Alessandra", "initials": "A", "orcid": "0000-0003-3818-0871", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b23966a465254ca6bbcd2c8ded62de72.json"}}, {"family": "Planas", "given": "Anna M", "initials": "AM"}, {"family": "Ludwig", "given": "Kerstin U", "initials": "KU", "orcid": "0000-0002-8541-2519", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02922a1f71c64a8e9dc6aa1c29a20270.json"}}, {"family": "Buti", "given": "Maria", "initials": "M"}, {"family": "Rahmouni", "given": "Souad", "initials": "S"}, {"family": "Alarc\u00f3n-Riquelme", "given": "Marta E", "initials": "ME"}, {"family": "Schulte", "given": "Eva C", "initials": "EC"}, {"family": "Franke", "given": "Andre", "initials": "A"}, {"family": "Karlsen", "given": "Tom H", "initials": "TH"}, {"family": "Valenti", "given": "Luca", "initials": "L"}, {"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "Richards", "given": "Brent", "initials": "B"}, {"family": "Ganna", "given": "Andrea", "initials": "A"}, {"family": "Boada", "given": "Merc\u00e8", "initials": "M"}, {"family": "Rojas", "given": "Itziar", "initials": "I"}, {"family": "Ruiz", "given": "Agust\u00edn", "initials": "A"}, {"family": "S\u00e1nchez", "given": "Pascual", "initials": "P"}, {"family": "Real", "given": "Luis Miguel", "initials": "LM"}, {"family": "SCOURGE Cohort Group", "given": "", "initials": ""}, {"family": "HOSTAGE Cohort Group", "given": "", "initials": ""}, {"family": "GRA@CE Cohort Group", "given": "", "initials": ""}, {"family": "Guillen-Navarro", "given": "Encarna", "initials": "E"}, {"family": "Ayuso", "given": "Carmen", "initials": "C"}, {"family": "Gonz\u00e1lez-Neira", "given": "Anna", "initials": "A"}, {"family": "Riancho", "given": "Jos\u00e9 A", "initials": "JA"}, {"family": "Rojas-Martinez", "given": "Augusto", "initials": "A", "orcid": "0000-0003-3765-6778", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e1011d5dcbe44319ea2cd8a03e63105.json"}}, {"family": "Flores", "given": "Carlos", "initials": "C"}, {"family": "Lapunzina", "given": "Pablo", "initials": "P"}, {"family": "Carracedo", "given": "\u00c1ngel", "initials": "\u00c1"}], "type": "journal article", "published": "2022-06-16", "journal": {"title": "Hum Mol Genet", "issn": "1460-2083", "issn-l": null}, "abstract": "Here we describe the results of a genome-wide study conducted in 11 939 COVID-19 positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (p < 5x10-8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (p = 1.3x10-22 and p = 8.1x10-12, respectively), and for variants in 9q21.32 near TLE1 only among females (p = 4.4x10-8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (p = 2.7x10-8) and ARHGAP33 (p = 1.3x10-8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, p = 4.1x10-8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or \u2265 60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.", "doi": "10.1093/hmg/ddac132", "pmid": "35708486", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6607933"}], "notes": [], "created": "2022-06-20T18:08:48.923Z", "modified": "2022-08-17T12:48:40.142Z"}, {"entity": "publication", "iuid": "2be82183ca284e4181fb956bc2d63ab6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2be82183ca284e4181fb956bc2d63ab6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2be82183ca284e4181fb956bc2d63ab6"}}, "title": "Lifestyle behaviors in Swedish university students before and during the first six months of the COVID-19 pandemic: a cohort study.", "authors": [{"family": "Larsson", "given": "Kristina", "initials": "K"}, {"family": "Onell", "given": "Clara", "initials": "C"}, {"family": "Edlund", "given": "Klara", "initials": "K"}, {"family": "K\u00e4llberg", "given": "Henrik", "initials": "H"}, {"family": "Holm", "given": "Lena W", "initials": "LW"}, {"family": "Sundberg", "given": "Tobias", "initials": "T"}, {"family": "Skillgate", "given": "Eva", "initials": "E"}], "type": "journal article", "published": "2022-06-16", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "1207", "issn-l": null}, "abstract": "Changes in Swedish university students' lifestyle behaviors during the COVID-19 pandemic are unknown. This study aimed to assess physical activity, sitting time, meal frequency and risk substance use (alcohol, tobacco, and illicit use of drugs) in Swedish university students before and during the first six months of the COVID-19 pandemic, for all and stratified by age and sex.\n\nData were obtained from the Sustainable University Life cohort study in which web-based surveys were sent to university students repeatedly for one year. Baseline assessment (before the pandemic) was between August 2019-March 2020, follow-up 1 (FU1) between March-June 2020, and follow-up 2 (FU2) between June-September 2020. Participants reported weekly minutes of physical activity, daily sitting hours, meal frequency by weekly intake of different meals, and motivation for eating irregularly, if so. Also, harmful use of alcohol, tobacco and illicit drugs was assessed. Population means and differences with 95% confidence intervals (95% CI) in lifestyle behaviors between time points were calculated with Generalized Estimating Equations.\n\n1877 students (73% women, mean age 26.5 years) answered the baseline survey. Weekly exercise decreased by -5.7 min (95% CI: -10.0, -1.5) and -7.7 min (95% CI: -12.6, -2.8) between baseline and FU1 and FU2, respectively. Weekly daily activities increased by 5.6 min (95% CI: 0.3, 11.7) and 14.2 min (95% CI: 7.9, 20.5) between baseline and FU1 and FU2. Daily sitting time decreased by -1.4 h (95% CI: -1.7, -1.2) between baseline and FU2. Breakfast intake increased by 0.2 days per week (95% CI: 0.1, 0.3) between baseline and FU2. Lunch intake decreased by -0.2 days per week (95% CI: -0.2, -0.1) between baseline and FU1 and by -0.2 days per week (95% CI: -0.3, -0.0) between baseline and FU2. Dinner intake decreased by -0.1 days per week (95% CI: -0.2, -0.0) between baseline and both FU1 and FU2. Only minor differences in risk substance use were observed. Similar changes were observed in analyses stratified by age and sex.\n\nLifestyle behaviors in Swedish university students slightly improved during the first six months of the COVID-19 pandemic compared to before.\n\nClinicalTrials.gov, NCT04465435 . 10/07/2020.", "doi": "10.1186/s12889-022-13553-7", "pmid": "35710368", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-022-13553-7"}, {"db": "pmc", "key": "PMC9202972"}, {"db": "ClinicalTrials.gov", "key": "NCT04465435"}], "notes": [], "created": "2022-06-20T18:06:39.900Z", "modified": "2022-08-17T12:47:29.378Z"}, {"entity": "publication", "iuid": "cab6d6e06fcb4e34bd7e7ffbb1a41682", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cab6d6e06fcb4e34bd7e7ffbb1a41682.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cab6d6e06fcb4e34bd7e7ffbb1a41682"}}, "title": "High Challenge Exercise and Learning Safe Landing Strategies among Community-Dwelling Older Adults: A Randomized Controlled Trial.", "authors": [{"family": "Arkkukangas", "given": "Marina", "initials": "M", "orcid": "0000-0001-7418-6088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70124d2b28fa4f8f868fb90bc786118d.json"}}, {"family": "Str\u00f6mqvist B\u00e5\u00e5the", "given": "Karin", "initials": "K"}, {"family": "Ekholm", "given": "Anna", "initials": "A"}, {"family": "Tonkonogi", "given": "Michail", "initials": "M"}], "type": "journal article", "published": "2022-06-16", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "12", "issn-l": null}, "abstract": "There is limited research on optimal exercise programs that effectively decrease falls and fall-related injuries in older populations. This randomized controlled trial (RCT) aimed to explore the effects of a 12-week Judo4Balance program on falling techniques, physical and psychological functions, health status, and physical activity levels among 200 community-dwelling older adults (79% women and 21% men) with a mean age of 72 years. The 200 participants were randomly allocated for the Judo4Balce program (n = 100) or control group (n = 100). The RCT intervention started in mid-January 2020 and was abruptly interrupted because of the COVID-19 pandemic. A restart of the RCT was initiated in September 2021, and the 12-week intervention was offered to two groups. This study reports the results from three points of assessment: baseline, 20-month follow-up, and 12-week postintervention. At 20 months follow-up, the control group had significantly decreased physical activity levels (summer p = 0.002 and winter p = 0.003); similar changes were not seen in the exercise group. In the exercise group, learning falling techniques in 6-9 weeks led to sustained fall competence at 20 months follow-up. Further, significant improvements in physical function (exercise group p = 0.009 and control group p &lt; 0.001) and learning falling techniques (p &lt; 0.001 for both groups) were noted in both groups after the 12-week intervention. This effective, supervised, group-based, high-challenge multicomponent exercise program needs to be further evaluated for possible impact on falls and fall-related injuries.", "doi": "10.3390/ijerph19127370", "pmid": "35742618", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19127370"}, {"db": "pmc", "key": "PMC9223480"}], "notes": [], "created": "2022-08-19T05:45:44.848Z", "modified": "2022-08-19T05:45:44.908Z"}, {"entity": "publication", "iuid": "33b737c22915436baa62eeefe8b586aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/33b737c22915436baa62eeefe8b586aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/33b737c22915436baa62eeefe8b586aa"}}, "title": "Private sector engagement in the COVID-19 response: experiences and lessons from the Democratic Republic of Congo, Nigeria, Senegal and Uganda.", "authors": [{"family": "Kabwama", "given": "Steven N", "initials": "SN"}, {"family": "Kiwanuka", "given": "Suzanne N", "initials": "SN"}, {"family": "Mapatano", "given": "Mala Ali", "initials": "MA"}, {"family": "Fawole", "given": "Olufunmilayo I", "initials": "OI"}, {"family": "Seck", "given": "Ibrahima", "initials": "I"}, {"family": "Namale", "given": "Alice", "initials": "A"}, {"family": "Ndejjo", "given": "Rawlance", "initials": "R"}, {"family": "Kizito", "given": "Susan", "initials": "S"}, {"family": "Monje", "given": "Fred", "initials": "F"}, {"family": "Bosonkie", "given": "Marc", "initials": "M"}, {"family": "Egbende", "given": "Landry", "initials": "L"}, {"family": "Bello", "given": "Segun", "initials": "S"}, {"family": "Bamgboye", "given": "Eniola A", "initials": "EA"}, {"family": "Dairo", "given": "Magbagbeola D", "initials": "MD"}, {"family": "Adebowale", "given": "Ayo S", "initials": "AS"}, {"family": "Salawu", "given": "Mobolaji M", "initials": "MM"}, {"family": "Afolabi", "given": "Rotimi F", "initials": "RF"}, {"family": "Diallo", "given": "Issakha", "initials": "I"}, {"family": "Leye", "given": "Mamadou M M", "initials": "MMM"}, {"family": "Ndiaye", "given": "Youssou", "initials": "Y"}, {"family": "Fall", "given": "Mane", "initials": "M"}, {"family": "Bassoum", "given": "Oumar", "initials": "O"}, {"family": "Alfv\u00e9n", "given": "Tobias", "initials": "T"}, {"family": "Sambisa", "given": "William", "initials": "W"}, {"family": "Wanyenze", "given": "Rhoda K", "initials": "RK"}], "type": "journal article", "published": "2022-06-15", "journal": {"title": "Global Health", "issn": "1744-8603", "issn-l": "1744-8603", "volume": "18", "issue": "1", "pages": "60"}, "abstract": "Private entities play a major role in health globally. However, their contribution has not been fully optimized to strengthen delivery of public health services. The COVID-19 pandemic has overwhelmed health systems and precipitated coalitions between public and private sectors to address critical gaps in the response. We conducted a study to document the public and private sector partnerships and engagements to inform current and future responses to public health emergencies.\r\n\r\nThis was a multi-country cross-sectional study conducted in the Democratic Republic of Congo, Nigeria, Senegal and Uganda between November 2020 and March 2021 to assess responses to the COVID-19 pandemic. We conducted a scoping literature review and key informant interviews (KIIs) with private and public health sector stakeholders. The literature reviewed included COVID-19 country guidelines and response plans, program reports and peer-reviewed and non-peer-reviewed publications. KIIs elicited information on country approaches and response strategies specifically the engagement of the private sector in any of the strategic response operations.\r\n\r\nAcross the 4 countries, private sector strengthened laboratory systems, COVID-19 case management, risk communication and health service continuity. In the DRC and Nigeria, private entities supported contact tracing and surveillance activities. Across the 4 countries, the private sector supported expansion of access to COVID-19 testing services through establishing partnerships with the public health sector albeit at unregulated fees. In Senegal and Uganda, governments established partnerships with private sector to manufacture COVID-19 rapid diagnostic tests. The private sector also contributed to treatment and management of COVID-19 cases. In addition, private entities provided personal protective equipment, conducted risk communication to promote adherence to safety procedures and health promotion for health service continuity. However, there were concerns related to reporting, quality and cost of services, calling for quality and price regulation in the provision of services.\r\n\r\nThe private sector contributed to the COVID-19 response through engagement in COVID-19 surveillance and testing, management of COVID-19 cases, and health promotion to maintain health access. There is a need to develop regulatory frameworks for sustainable public-private engagements including regulation of pricing, quality assurance and alignment with national plans and priorities during response to epidemics.", "doi": "10.1186/s12992-022-00853-1", "pmid": "35705961", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12992-022-00853-1"}, {"db": "pmc", "key": "PMC9199342"}], "notes": [], "created": "2022-06-20T18:10:41.041Z", "modified": "2022-08-17T12:58:09.908Z"}, {"entity": "publication", "iuid": "f9435aa3f85149de9a87c626478db9a5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f9435aa3f85149de9a87c626478db9a5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f9435aa3f85149de9a87c626478db9a5"}}, "title": "A prolonged innate systemic immune response in COVID-19.", "authors": [{"family": "Ekstedt", "given": "Sandra", "initials": "S"}, {"family": "Piersiala", "given": "Krzysztof", "initials": "K"}, {"family": "Petro", "given": "Marianne", "initials": "M"}, {"family": "Karlsson", "given": "Agneta", "initials": "A"}, {"family": "K\u00e5gedal", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Kumlien Geor\u00e9n", "given": "Susanna", "initials": "S"}, {"family": "Cardell", "given": "Lars Olaf", "initials": "LO"}], "type": "journal article", "published": "2022-06-15", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "9915", "issn-l": "2045-2322"}, "abstract": "Despite the introduction of vaccines, COVID-19 still affects millions of people worldwide. A better understanding of pathophysiology and the discovery of novel therapies are needed. One of the cells of interest in COVID-19 is the neutrophil. This cell type is being recruited to a site of inflammation as one of the first immune cells. In this project, we investigated a variety of neutrophils phenotypes during COVID-19 by measuring the expression of markers for migration, maturity, activation, gelatinase granules and secondary granules using flow cytometry. We show that neutrophils during COVID-19 exhibit altered phenotypes compared to healthy individuals. The activation level including NETs production and maturity of neutrophils seem to last longer during COVID-19 than expected for innate immunity. Neutrophils as one of the drivers of severe cases of COVID-19 are considered as potential treatment targets. However, for a successful implementation of treatment, there is a need for a better understanding of neutrophil functions and phenotypes in COVID-19. Our study answers some of those questions.", "doi": "10.1038/s41598-022-13986-5", "pmid": "35705573", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-13986-5"}, {"db": "pmc", "key": "PMC9200737"}], "notes": [], "created": "2022-06-20T18:11:26.239Z", "modified": "2022-08-17T12:58:20.345Z"}, {"entity": "publication", "iuid": "87cbba284ec34ff1b0a29296baf8f31a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87cbba284ec34ff1b0a29296baf8f31a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87cbba284ec34ff1b0a29296baf8f31a"}}, "title": "The Every Woman Every Child initiative: supporting countries in Latin America and the Caribbean to reduce social inequalities in health.", "authors": [{"family": "Sanhueza", "given": "Antonio", "initials": "A", "orcid": "0000-0002-1857-3662", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a16398c86edb49bd8bc6c4b70008e040.json"}}, {"family": "Carvajal", "given": "Liliana", "initials": "L", "orcid": "0000-0003-1971-7055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08223ee314804fd897aa13f5e08f7c1d.json"}}, {"family": "Cueva", "given": "Daniel A", "initials": "DA", "orcid": "0000-0002-1871-4680", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be76e4e1e7eb42179379897988af880d.json"}}, {"family": "Caffe", "given": "Sonja", "initials": "S"}, {"family": "Camacho", "given": "Alma Virginia", "initials": "AV"}, {"family": "Berroter\u00e1n", "given": "Mar\u00eda Alejandra", "initials": "MA"}, {"family": "Horowitz", "given": "Deborah", "initials": "D"}, {"family": "Gordillo-Tobar", "given": "Amparo", "initials": "A"}, {"family": "Mujica", "given": "Oscar J", "initials": "OJ", "orcid": "0000-0002-2893-4206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08cf1633e028495ca74ec9513246060b.json"}}, {"family": "Every Woman Every Child Latin America and the Caribbean", "given": "", "initials": ""}], "type": "letter", "published": "2022-06-14", "journal": {"title": "Int J Equity Health", "issn": "1475-9276", "volume": "21", "issue": "1", "pages": "83", "issn-l": null}, "abstract": "The Every Woman Every Child Latin America and the Caribbean (EWEC-LAC) initiative was established in 2017 as a regional inter-agency mechanism. EWEC-LAC coordinates the regional implementation of the Global Strategy for Women's, Children's and Adolescents' Health in Latin America and the Caribbean (LAC), including adaptation to region specific needs, to end preventable deaths, ensure health and well-being and expand enabling environments for the health and well-being of women, children and adolescents. To advance the equitable achievement of these objectives, EWEC-LAC's three working groups collectively support LAC countries in measuring and monitoring social inequalities in health, advocating for their reduction, and designing and implementing equity-oriented strategies, policies and interventions. This support for data-driven advocacy, capacity building, and policy and program solutions toward closing current gaps ensures that no one is left behind. Members of EWEC-LAC include PAHO, UNAIDS, UNFPA, UNICEF, UN WOMEN, the World Bank, the Inter-American Development Bank, USAID, LAC Regional Neonatal Alliance, and the LAC Regional Task Force for the Reduction of Maternal Mortality. To date, EWEC-LAC has developed and collected innovative tools and resources and begun to engage with countries to utilize them to reduce equity gaps. These resources include a framework for the measurement of social inequalities in health, data use and advocacy tools including a data dashboard to visualize trends in social inequalities in health in LAC countries, a methodology for setting targets for the reduction of inequalities, and a compendium of tools, instruments and methods to identify and address social inequalities in health. EWEC-LAC has also engaged regionally to emphasize the importance of recognizing these inequalities at social and political levels, and advocated for the reduction of these gaps. Attention to closing health equity gaps is ever more critical in the face of the COVID-19 pandemic which has exploited existing vulnerabilities. More equitable health systems will be better prepared to confront future health shocks.", "doi": "10.1186/s12939-022-01682-9", "pmid": "35701816", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12939-022-01682-9"}], "notes": [], "created": "2022-06-20T18:15:07.473Z", "modified": "2022-06-20T18:15:29.423Z"}, {"entity": "publication", "iuid": "c2262a7305c24e51974c262e891ff157", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2262a7305c24e51974c262e891ff157.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2262a7305c24e51974c262e891ff157"}}, "title": "Impaired Antibody Response Is Associated with Histone-Release, Organ Dysfunction and Mortality in Critically Ill COVID-19 Patients.", "authors": [{"family": "Lagedal", "given": "Rickard", "initials": "R"}, {"family": "Eriksson", "given": "Oskar", "initials": "O"}, {"family": "S\u00f6rman", "given": "Anna", "initials": "A", "orcid": "0000-0002-1037-1601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7aa6b3c26f634d14be04dc910700ef9f.json"}}, {"family": "Huckriede", "given": "Joram B", "initials": "JB"}, {"family": "Kristensen", "given": "Bjarne", "initials": "B"}, {"family": "Franz\u00e9n", "given": "Stephanie", "initials": "S", "orcid": "0000-0002-5003-2508", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e3799688c8d441fb9f3b62655c75ac26.json"}}, {"family": "Larsson", "given": "Anders", "initials": "A", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2be858ab604743b72383dfdcd14689.json"}}, {"family": "Bergqvist", "given": "Anders", "initials": "A", "orcid": "0000-0002-5789-8777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b0f16ae981064b70adf451e7fb517ab2.json"}}, {"family": "Alving", "given": "Kjell", "initials": "K", "orcid": "0000-0003-0784-0443", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa7365da4fc24c419cedd5d4e3266262.json"}}, {"family": "Forslund", "given": "Anders", "initials": "A"}, {"family": "Persson", "given": "Barbro", "initials": "B"}, {"family": "Ekdahl", "given": "Kristina N", "initials": "KN", "orcid": "0000-0001-7888-1571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a345be186f64a6ea106a3616baec50e.json"}}, {"family": "Garcia de Frutos", "given": "Pablo", "initials": "P", "orcid": "0000-0003-1547-1190", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8aa9ad9840f4838bb74c9eb3aac9658.json"}}, {"family": "Nilsson", "given": "Bo", "initials": "B"}, {"family": "Nicolaes", "given": "Gerry A F", "initials": "GAF"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}], "type": "journal article", "published": "2022-06-14", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "11", "issue": "12", "pages": null}, "abstract": "the pathophysiologic mechanisms explaining differences in clinical outcomes following COVID-19 are not completely described. This study aims to investigate antibody responses in critically ill patients with COVID-19 in relation to inflammation, organ failure and 30-day survival.\r\n\r\nAll patients with PCR-verified COVID-19 and gave consent, and who were admitted to a tertiary Intensive care unit (ICU) in Sweden during March-September 2020 were included. Demography, repeated blood samples and measures of organ function were collected. Analyses of anti-SARS-CoV-2 antibodies (IgM, IgA and IgG) in plasma were performed and correlated to patient outcome and biomarkers of inflammation and organ failure.\r\n\r\nA total of 115 patients (median age 62 years, 77% male) were included prospectively. All patients developed severe respiratory dysfunction, and 59% were treated with invasive ventilation. Thirty-day mortality was 22.6% for all included patients. Patients negative for any anti-SARS-CoV-2 antibody in plasma during ICU admission had higher 30-day mortality compared to patients positive for antibodies. Patients positive for IgM had more ICU-, ventilator-, renal replacement therapy- and vasoactive medication-free days. IgA antibody concentrations correlated negatively with both SAPS3 and maximal SOFA-score and IgM-levels correlated negatively with SAPS3. Patients with antibody levels below the detection limit had higher plasma levels of extracellular histones on day 1 and elevated levels of kidney and cardiac biomarkers, but showed no signs of increased inflammation, complement activation or cytokine release. After adjusting for age, positive IgM and IgG antibodies were still associated with increased 30-day survival, with odds ratio (OR) 7.1 (1.5-34.4) and 4.2 (1.1-15.7), respectively.\r\n\r\nIn patients with severe COVID-19 requiring intensive care, a poor antibody response is associated with organ failure, systemic histone release and increased 30-day mortality.", "doi": "10.3390/jcm11123419", "pmid": "35743491", "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "jcm11123419"}, {"db": "pmc", "key": "PMC9225468"}], "notes": [], "created": "2022-08-19T05:45:15.313Z", "modified": "2022-08-19T12:35:58.860Z"}, {"entity": "publication", "iuid": "f58f8a46b9894a2a99afee5da9ebc9c6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f58f8a46b9894a2a99afee5da9ebc9c6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f58f8a46b9894a2a99afee5da9ebc9c6"}}, "title": "Care home managers' views on the media coverage of COVID-19 outbreaks in care homes for older adults: A case study in Stockholm.", "authors": [{"family": "Morath", "given": "Lenke P", "initials": "LP"}, {"family": "Burstr\u00f6m", "given": "Bo", "initials": "B"}, {"family": "Liljas", "given": "Ann E M", "initials": "AEM", "orcid": "0000-0002-2358-6046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/669cff9e8a5b4042bd0019b7bd92d162.json"}}], "type": "journal article", "published": "2022-06-14", "journal": {"title": "Int J Older People Nurs", "issn": "1748-3743", "pages": "e12483", "issn-l": null}, "abstract": "The COVID-19 pandemic has particularly affected older adults and resulted in high rates of infections and deaths in care homes. We have conducted a case study in which three managers of care homes for older adults in central Stockholm have shared their thoughts on the media coverage of care homes for older adults during the COVID-19 pandemic. We analysed the data using conventional content analysis and identified three themes and five categories. The results show that the managers experienced the media coverage of care homes during the pandemic to be negative and incomplete, causing feelings of sadness and shame amongst themselves and their staff. The negative media coverage further generated added workload as they had to arrange for discussions to answer questions by staff and close relatives of the residents. Informants also thought that there is a lack of knowledge about the role of care homes and subsequently what to expect of them. Finally, informants reported that the pandemic might create an opportunity for system-level policy changes. In light of this, we discuss possible victim blaming of staff and how greater public awareness of the care home sector could facilitate for a debate on policy changes and the low social status of caring for older adults.", "doi": "10.1111/opn.12483", "pmid": "35699305", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9350000"}], "notes": [], "created": "2022-06-20T18:16:23.183Z", "modified": "2022-08-17T13:02:38.833Z"}, {"entity": "publication", "iuid": "51b7cb22b9794702a310bb4b49798ee4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/51b7cb22b9794702a310bb4b49798ee4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/51b7cb22b9794702a310bb4b49798ee4"}}, "title": "COVID-19 outcomes in haematopoietic cell transplant recipients: A systematic review and meta-analysis.", "authors": [{"family": "Lim", "given": "Yeong Jer", "initials": "YJ", "orcid": "0000-0002-9022-2904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8c08d684e83431b99d44a7a612b6325.json"}}, {"family": "Khan", "given": "Umair", "initials": "U"}, {"family": "Karpha", "given": "Indrani", "initials": "I"}, {"family": "Ross", "given": "Andrew", "initials": "A"}, {"family": "Saif", "given": "Muhammad", "initials": "M"}, {"family": "Remberger", "given": "Mats", "initials": "M"}, {"family": "Kalakonda", "given": "Nagesh", "initials": "N"}, {"family": "Pettitt", "given": "Andrew R", "initials": "AR"}, {"family": "Floisand", "given": "Yngvar", "initials": "Y"}], "type": "journal article", "published": "2022-06-14", "journal": {"title": "EJHaem", "issn": "2688-6146", "issn-l": null}, "abstract": "Up-to-date information on coronavirus disease 2019 (COVID-19) outcomes and risk factors in haematopoietic cell transplantation (HCT) recipients is required to inform on decisions about cancer treatment and COVID-19 mitigation strategies. We performed a meta-analysis to address this knowledge gap. All studies with at least five patients who reported COVID-19-related deaths in HCT recipients were included. The primary outcome was COVID-19-related death. Secondary outcomes were COVID-19-related mechanical ventilation (MV) and intensive care unit (ITU) admission. The cumulative COVID-19-related death rate among HCT recipients was 21% (95% confidence interval [CI] 18%-24%), while MV and ITU admission rates were 14% (95% CI 11%-17%) and 18% (95% CI 14%-22%), respectively. Subgroup analysis showed higher death rates in patients who developed COVID-19 within 12 months of HCT (risk ratio [RR] 1.82, 95% CI 1.09-3.03), within 6 months of receiving immunosuppressant drugs (RR 2.11, 95% CI 1.38-3.20) or in the context of active graft-versus-host disease (RR 2.38, 95% CI 1.10-5.16). Our findings support the idea that HCT should remain an integral part of cancer treatment during the COVID-19 pandemic but also highlight the need to prioritise preventative measures in those patients who are at increased risk of adverse COVID-19 outcomes.", "doi": "10.1002/jha2.465", "pmid": "35941880", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "JHA2465"}, {"db": "pmc", "key": "PMC9350043"}], "notes": [], "created": "2022-08-11T11:51:25.952Z", "modified": "2022-08-11T11:51:56.016Z"}, {"entity": "publication", "iuid": "c9f0e8da00d74515a863b2bed87412d1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9f0e8da00d74515a863b2bed87412d1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9f0e8da00d74515a863b2bed87412d1"}}, "title": "Athletes' Mesenchymal Stem Cells Could Be the Best Choice for Cell Therapy in Omicron-Infected Patients.", "authors": [{"family": "Saheli", "given": "Mona", "initials": "M"}, {"family": "Khoramipour", "given": "Kayvan", "initials": "K"}, {"family": "Vosough", "given": "Massoud", "initials": "M", "orcid": "0000-0001-5924-4366", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bf15c1fec524a79b8801694434587e3.json"}}, {"family": "Piryaei", "given": "Abbas", "initials": "A", "orcid": "0000-0002-3182-6214", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1807b026f88d4af8837f34b8d313843f.json"}}, {"family": "Rahmati", "given": "Masoud", "initials": "M", "orcid": "0000-0003-4792-027X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b5fa1a704f045eb97ff31ce02591801.json"}}, {"family": "Suzuki", "given": "Katsuhiko", "initials": "K", "orcid": "0000-0002-6572-5809", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00c6d85718554e2b9fd967bc69514508.json"}}], "type": "journal article", "published": "2022-06-14", "journal": {"title": "Cells", "issn": "2073-4409", "volume": "11", "issue": "12", "issn-l": null}, "abstract": "New severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, Omicron, contains 32 mutations that have caused a high incidence of breakthrough infections or re-infections. These mutations have reduced vaccine protection against Omicron and other new emerging variants. This highlights the need to find effective treatment, which is suggested to be stem cell-based therapy. Stem cells could support respiratory epithelial cells and they could restore alveolar bioenergetics. In addition, they can increase the secretion of immunomodulatory cytokines. However, after transplantation, cell survival and growth rate are low because of an inappropriate microenvironment, and stem cells face ischemia, inflammation, and oxidative stress in the transplantation niche which reduces the cells' survival and growth. Exercise-training can upregulate antioxidant, anti-inflammatory, and anti-apoptotic defense mechanisms and increase growth signaling, thereby improving transplanted cells' survival and growth. Hence, using athletes' stem cells may increase stem-cell therapy outcomes in Omicron-affected patients.", "doi": "10.3390/cells11121926", "pmid": "35741055", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "cells11121926"}, {"db": "pmc", "key": "PMC9221912"}], "notes": [], "created": "2022-08-19T05:48:12.702Z", "modified": "2022-08-19T05:48:12.833Z"}, {"entity": "publication", "iuid": "7cb12a386d7c47e4b404b7d606141ad1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7cb12a386d7c47e4b404b7d606141ad1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7cb12a386d7c47e4b404b7d606141ad1"}}, "title": "Olfactory distortions in the general population.", "authors": [{"family": "Olofsson", "given": "Jonas K", "initials": "JK"}, {"family": "Ekesten", "given": "Fredrik", "initials": "F"}, {"family": "Nordin", "given": "Steven", "initials": "S"}], "type": "journal article", "published": "2022-06-13", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "9776", "issn-l": "2045-2322"}, "abstract": "Parosmia, distorted smell sensations, is a common consequence of respiratory virus infections. The phenomenon is not well understood in terms of its impact and long-term outcomes. We examined self-reported experiences of parosmia in a population-based sample from the Betula study that was conducted in Ume\u00e5 in northern Sweden (baseline data collected in 1998-2000). We used a baseline sample of 2168 individuals aged 35-90 years and with no cognitive impairment at baseline. We investigated the prevalence of parosmia experiences and, using regression analyses, its relationship to other olfactory and cognitive variables and quality of life. Benefitting from the longitudinal study design, we also assessed the persistence of parosmia over 5 and 10 years prospectively. Parosmia experiences were prevalent in 4.8% of the population and it often co-occurred with phantosmia (\"olfactory hallucinations\"), but was not associated with lower self-rated overall quality of life or poor performance on olfactory or cognitive tests. For some individuals, parosmia was retained 5 years (17.0%) or even 10 years later (10.3%). Thus, parosmia experiences are commonly reported in the population, and can be persistent for some individuals, but might be mostly benign in nature. Our work complements research on clinical-level parosmia, which is typically more severe, and recent parosmia reports during the COVID-19 pandemic, where long-term outcomes are still unknown.", "doi": "10.1038/s41598-022-13201-5", "pmid": "35697904", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-13201-5"}], "notes": [], "created": "2022-06-20T18:18:24.318Z", "modified": "2022-06-20T18:18:24.332Z"}, {"entity": "publication", "iuid": "f461eb0c2e0f4a5cb43861847a056bfa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f461eb0c2e0f4a5cb43861847a056bfa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f461eb0c2e0f4a5cb43861847a056bfa"}}, "title": "Influence on study outcomes of an inpatient study by the behavior of the study staff (PINgPOng): study protocol for a randomized clinical trial.", "authors": [{"family": "Coenen", "given": "Martin", "initials": "M", "orcid": "0000-0003-0439-4409", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5bf4db2156e4f24b3ffcd88a024da9a.json"}}, {"family": "Bingel", "given": "Ulrike", "initials": "U"}, {"family": "Zunhammer", "given": "Matthias", "initials": "M"}, {"family": "Berdaguer", "given": "Maria Soledad", "initials": "MS"}, {"family": "Fuhrmann", "given": "Christine", "initials": "C"}, {"family": "Fimmers", "given": "Rolf", "initials": "R"}, {"family": "Rengelshausen", "given": "Jens", "initials": "J"}, {"family": "Hartmann", "given": "Gunther", "initials": "G"}, {"family": "Schedlowski", "given": "Manfred", "initials": "M"}, {"family": "Coch", "given": "Christoph", "initials": "C"}], "type": "clinical trial protocol", "published": "2022-06-13", "journal": {"title": "Trials", "issn": "1745-6215", "volume": "23", "issue": "1", "pages": "488", "issn-l": null}, "abstract": "The placebo effect as the symptom improvement following inert treatments is a fixed component of RCTs to differentiate between specific effects of the tested pharmacological substance from other unspecific effects. The PINgPOng study was set up to analyze the influence of a study team trained to either minimize the placebo response and optimize drug-placebo differences or to maximize the placebo response to increase drug efficacy by unspecific factors on the study results of a RCT in a classical early clinical trial setting.\n\nPINgPOng is a single-center, prospective, randomized, double-blind, placebo-controlled study in a 3-group, 2-sequence, 2-period cross-over design. The study is conducted according to the principles of ICH-GCP and the Declaration of Helsinki on the Phase I-Unit of the University Hospital Bonn. The primary endpoint is the pain intensity in the cold pressor test before and after the administration of 15 mg oxycodone or placebo. The pain intensity is compared between three study conditions: 32 healthy volunteers in each study arm will be treated either by an untrained study team (arm A), by a study team trained to maximize (arm B), or to minimize placebo responses (arm C). Neuroendocrine factors (alpha-amylase activity, salivary cortisol), characteristic traits (anxiety, depression, stress), and somatic reactions are analyzed as covariates of the pain perception.\n\nThe PINgPOng study will allow to answer the question whether and to what extent the behavior of a trained study team (neutral vs. maximize vs. minimize placebo responses) will differentially affect placebo responses in a setting of a highly standardized early clinical trial. The results will help to control the placebo effects by education of the clinical study team and to avoid unnecessary high placebo effects in clinical development.\n\nGerman Clinical Trials Register DRKS00013586 . Registered on December 22, 2017.", "doi": "10.1186/s13063-022-06436-0", "pmid": "35698101", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13063-022-06436-0"}], "notes": [], "created": "2022-06-20T18:18:10.247Z", "modified": "2022-06-20T18:18:10.298Z"}, {"entity": "publication", "iuid": "2ab7837ec8724d3f8643dda0d357dc01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ab7837ec8724d3f8643dda0d357dc01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ab7837ec8724d3f8643dda0d357dc01"}}, "title": "Factors Associated With the Decay of Anti-SARS-CoV-2 S1 IgG Antibodies Among Recipients of an Adenoviral Vector-Based AZD1222 and a Whole-Virion Inactivated BBV152 Vaccine.", "authors": [{"family": "Selvavinayagam", "given": "Sivaprakasam T", "initials": "ST"}, {"family": "Yong", "given": "Yean Kong", "initials": "YK"}, {"family": "Tan", "given": "Hong Yien", "initials": "HY"}, {"family": "Zhang", "given": "Ying", "initials": "Y"}, {"family": "Subramanian", "given": "Gurunathan", "initials": "G"}, {"family": "Rajeshkumar", "given": "Manivannan", "initials": "M"}, {"family": "Vasudevan", "given": "Kalaivani", "initials": "K"}, {"family": "Jayapal", "given": "Priyanka", "initials": "P"}, {"family": "Narayanasamy", "given": "Krishnasamy", "initials": "K"}, {"family": "Ramesh", "given": "Dinesh", "initials": "D"}, {"family": "Palani", "given": "Sampath", "initials": "S"}, {"family": "Larsson", "given": "Marie", "initials": "M"}, {"family": "Shankar", "given": "Esaki M", "initials": "EM"}, {"family": "Raju", "given": "Sivadoss", "initials": "S"}], "type": "journal article", "published": "2022-06-13", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "9", "pages": "887974", "issn-l": null}, "abstract": "The magnitude of protection conferred following recovery from COVID-19 or by vaccine administration, and the duration of protective immunity developed, remains ambiguous.\n\nWe investigated the factors associated with anti-SARS-CoV-2 S1 IgG decay in 519 individuals who recovered from COVID-19 illness or received COVID-19 vaccination with two commercial vaccines, viz., an adenoviral vector-based (AZD1222) and a whole-virion-based inactivated (BBV152) vaccine in Chennai, India from March to December 2021. Blood samples collected during regular follow-up post-infection/-vaccination were examined for anti-SARS-CoV-2 S1 IgG by a commercial automated chemiluminescent immunoassay (CLIA).\n\nAge and underlying comorbidities were the two variables that were independently associated with the development of a breakthrough infection. Individuals who were >60 years of age with underlying comorbid conditions (viz., hypertension, diabetes mellitus and cardiovascular disease) had a ~15 times and ~10 times greater odds for developing a breakthrough infection and hospitalization, respectively. The time elapsed since the first booster dose was associated with attrition in anti-SARS-CoV-2 IgG, where each month passed was associated with an ebb in the anti-SARS-CoV-2 IgG antibody levels by a coefficient of -6 units.\n\nOur findings advocate that the elderly with underlying comorbidities be administered with appropriate number of booster doses with AZD1222 and BBV152 against COVID-19.", "doi": "10.3389/fmed.2022.887974", "pmid": "35770011", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9235407"}], "notes": [], "created": "2022-08-19T05:32:02.750Z", "modified": "2023-06-19T15:34:18.898Z"}, {"entity": "publication", "iuid": "1f548fe422a845ef8b31a29baa318722", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1f548fe422a845ef8b31a29baa318722.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1f548fe422a845ef8b31a29baa318722"}}, "title": "Compliance of healthcare workers with the infection prevention and control guidance in tertiary care hospitals: quantitative findings from an explanatory sequential mixed-methods study in Bangladesh.", "authors": [{"family": "Salwa", "given": "Marium", "initials": "M", "orcid": "0000-0001-7869-3343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc49c7c98d32429387b54911fb024274.json"}}, {"family": "Haque", "given": "M Atiqul", "initials": "MA"}, {"family": "Islam", "given": "Syed Shariful", "initials": "SS"}, {"family": "Islam", "given": "Mohammad Tanvir", "initials": "MT"}, {"family": "Sultana", "given": "Sarmin", "initials": "S"}, {"family": "Khan", "given": "Md Maruf Haque", "initials": "MMH"}, {"family": "Moniruzzaman", "given": "Syed", "initials": "S"}], "type": "journal article", "published": "2022-06-13", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "6", "pages": "e054837", "issn-l": "2044-6055"}, "abstract": "To assess healthcare workers' (HCWs) compliance with the infection prevention and control (IPC) practices and identify the factors influencing this compliance using the Health Belief Model as the theoretical framework.\n\nQuantitative data from an explanatory sequential mixed-methods study were employed in this research.\n\nFrom 17 May to 30 August 2020, 604 physicians and nurses working at six randomly selected tertiary care facilities in Dhaka City in Bangladesh took part in this study.\n\nCompliance with the WHO's guidance on IPC measures, as well as the associated factors, was the primary outcome.\n\nA mean compliance score of 0.49 (\u00b10.25) was observed on a 0-1 scale. HCWs were most compliant with the medical mask wearing guidelines (81%) and were least compliant with the high-touch surface decontamination regulations (23%). Compliance with the IPC guidance was significantly associated with increasing age, female sex, working as a nurse, having non-communicable diseases and history of exposure to patients with COVID-19. Perceived benefits (B=0.039, 95% CI 0.001 to 0.076), self-efficacy (B=0.101, 95% CI 0.060 to 0.142) and cues to action (B=0.045, 95% CI 0.002 to 0.088) were positively associated with compliance. Compliance with IPC guidance was 0.061 times greater among participants who reported low perceived barriers compared with those with high perceived barriers.\n\nOverall, compliance with IPC guidance among HCWs was unsatisfactory. As self-efficacy exerted the greatest contribution to compliance, it should be emphasised in any endeavour to improve HCWs' IPC adherence. Such interventions should also focus on perceived barriers, including unreliability of the information sources, unsafe working places and unavailability of protective equipment and cues to action, including trust in the administration and availability of adequate IPC guidance.", "doi": "10.1136/bmjopen-2021-054837", "pmid": "35697439", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-054837"}], "notes": [], "created": "2022-06-20T18:18:49.066Z", "modified": "2022-06-20T18:18:49.122Z"}, {"entity": "publication", "iuid": "123bc7ea77f849f0ade0b6b2b402043a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/123bc7ea77f849f0ade0b6b2b402043a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/123bc7ea77f849f0ade0b6b2b402043a"}}, "title": "Cohort Profile: COVIDMENT: COVID-19 cohorts on mental health across six nations.", "authors": [{"family": "Unnarsd\u00f3ttir", "given": "Anna B\u00e1ra", "initials": "AB", "orcid": "0000-0002-6421-445X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2da21ebd675c4e329c47bf64bbc1578a.json"}}, {"family": "Lovik", "given": "Anik\u00f3", "initials": "A"}, {"family": "Fawns-Ritchie", "given": "Chloe", "initials": "C"}, {"family": "Ask", "given": "Helga", "initials": "H"}, {"family": "K\u00f5iv", "given": "Kadri", "initials": "K"}, {"family": "Hagen", "given": "Kristen", "initials": "K"}, {"family": "Didriksen", "given": "Maria", "initials": "M", "orcid": "0000-0002-4856-496X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b0efe911882405c9d53fd4a49797d07.json"}}, {"family": "Christoffersen", "given": "Lea Arregui Nordahl", "initials": "LAN"}, {"family": "Gar\u00f0arsson", "given": "Alexander Berg", "initials": "AB"}, {"family": "McIntosh", "given": "Andrew", "initials": "A"}, {"family": "K\u00e4hler", "given": "Anna K", "initials": "AK"}, {"family": "Campbell", "given": "Archie", "initials": "A", "orcid": "0000-0003-0198-5078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e2c09aef9a6458e857d323d5447423d.json"}}, {"family": "Hauksd\u00f3ttir", "given": "Arna", "initials": "A"}, {"family": "Erikstrup", "given": "Christian", "initials": "C", "orcid": "0000-0001-6551-6647", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f01382b51d3e46d8b8c9d74dbed3ce81.json"}}, {"family": "Mikkelsen", "given": "Dorte Helenius", "initials": "DH"}, {"family": "Altschul", "given": "Drew", "initials": "D", "orcid": "0000-0001-7053-4209", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a158612fcea406284cb809b0e9eb6ac.json"}}, {"family": "Thordardottir", "given": "Edda Bjork", "initials": "EB"}, {"family": "Frans", "given": "Emma Maria", "initials": "EM"}, {"family": "Kvale", "given": "Gerd", "initials": "G"}, {"family": "T\u00f3masson", "given": "Gunnar", "initials": "G"}, {"family": "Kariis", "given": "Hanna Maria", "initials": "HM"}, {"family": "J\u00f3nsd\u00f3ttir", "given": "Harpa Lind", "initials": "HL"}, {"family": "R\u00fanarsd\u00f3ttir", "given": "Harpa", "initials": "H"}, {"family": "Magn\u00fasd\u00f3ttir", "given": "Ingibj\u00f6rg", "initials": "I"}, {"family": "Eid", "given": "Jarle", "initials": "J"}, {"family": "Jakobsd\u00f3ttir", "given": "J\u00f3hanna", "initials": "J"}, {"family": "Nielsen", "given": "Kaspar Ren\u00e9", "initials": "KR"}, {"family": "Kaspersen", "given": "Kathrine Agerg\u00e5rd", "initials": "KA"}, {"family": "Milani", "given": "Lili", "initials": "L"}, {"family": "Trogstad", "given": "Lill-Iren Schou", "initials": "LS"}, {"family": "Yi", "given": "Lu", "initials": "L"}, {"family": "Bruun", "given": "Mie Topholm", "initials": "MT"}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF"}, {"family": "Magnus", "given": "Per Minor", "initials": "PM"}, {"family": "Shen", "given": "Qing", "initials": "Q", "orcid": "0000-0002-7214-4797", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/940144ccf8434a33a287ed4ff191be8d.json"}}, {"family": "Nesv\u00e5g", "given": "Ragnar", "initials": "R"}, {"family": "Brandlistuen", "given": "Ragnhild E", "initials": "RE", "orcid": "0000-0001-8054-0960", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/95d019cbc4714bc28863d5e26db63b1a.json"}}, {"family": "M\u00e4gi", "given": "Reedik", "initials": "R"}, {"family": "Ostrowski", "given": "Sisse Rye", "initials": "SR"}, {"family": "L\u00f8khammer", "given": "Solveig", "initials": "S"}, {"family": "Solem", "given": "Stian", "initials": "S"}, {"family": "Reichborn-Kjennerud", "given": "Ted", "initials": "T"}, {"family": "Hansen", "given": "Thomas Folkmann", "initials": "TF"}, {"family": "Werge", "given": "Thomas", "initials": "T"}, {"family": "Aspelund", "given": "Thor", "initials": "T", "orcid": "0000-0002-7998-5433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f3b5030190743e4b0ec0be05afb8fa8.json"}}, {"family": "Porteous", "given": "David J", "initials": "DJ"}, {"family": "Fang", "given": "Fang", "initials": "F", "orcid": "0000-0002-3310-6456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b0852465cd14239a25329b976172792.json"}}, {"family": "Lehto", "given": "Kelli", "initials": "K"}, {"family": "Andreassen", "given": "Ole A", "initials": "OA"}, {"family": "Pedersen", "given": "Ole Birger Vesterager", "initials": "OBV"}, {"family": "Hellard", "given": "Stephanie Le", "initials": "SL"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}], "type": "journal article", "published": "2022-06-13", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "volume": "51", "issue": "3", "pages": "e108-e122", "issn-l": "0300-5771"}, "abstract": null, "doi": "10.1093/ije/dyab234", "pmid": "35020900", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8690101"}, {"db": "pii", "key": "6432503"}], "notes": [], "created": "2022-01-13T20:55:36.883Z", "modified": "2023-02-13T18:37:59.354Z"}, {"entity": "publication", "iuid": "c1e7d453c52d48b7bdcca526b7537a96", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1e7d453c52d48b7bdcca526b7537a96.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1e7d453c52d48b7bdcca526b7537a96"}}, "title": "A retrospective cohort study of the effect of SARS-CoV-2 point of care rapid RT-PCR at the Emergency Department on targeted admission.", "authors": [{"family": "Mortazavi", "given": "Susanne E", "initials": "SE"}, {"family": "Inghammar", "given": "Malin", "initials": "M"}, {"family": "Christiansen", "given": "Claus", "initials": "C"}, {"family": "Pesola", "given": "Anne-Katrine", "initials": "AK"}, {"family": "Stenkilsson", "given": "Mikael", "initials": "M"}, {"family": "Paulsson", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1104-2727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0e37d2d03f64fe78a0e84f53922d29f.json"}}], "type": "journal article", "published": "2022-06-13", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "volume": "22", "issue": "1", "pages": "536", "issn-l": null}, "abstract": "To prevent nosocomial transmission of SARS-CoV-2, infection prevention control (IPC) measures are implemented for patients with symptoms compatible with COVID-19 until reliable test results are available. This delays admission to the most appropriate ward based on the medical condition. SARS-CoV-2 rapid antigen detection (RAD) tests and point-of-care (POC) rapid RT-PCR (VitaPCR) were introduced at emergency department (ED) at Sk\u00e5ne University Hospital, Sweden in late 2020, but the consequence on patient flow and targeted admission is unknown.\n\nPatients presenting at the emergency department of a referral hospital (N = 2940) between 13-Nov-2020 and 12-Jan-2021 were included. The study period was delimited into three periods by the introduction of RAD tests and the VitaPCR. Participant data was collected from hospital records, and outcome variables were Length-of-Stay (LoS), intrahospital transfers and targeted admission to COVID-19 ward.\n\nCompared to baseline (RT-PCR only), RAD tests reduced ED Length-of-Stay (LoS) for participants with positive tests. Negative VitaPCR results reduced mean hospital LoS by 1.5 (95% CI 0.3-2.7) days and admissions to COVID-19 wards from 34.5 (95% CI 28.9-40.5) to 14.7 (95% CI 11.1-19.1) per 100 admissions and reduced transfers between hospital wards in the first 5 days from 50.0 (95% CI 45.0-55.0) to 34.0 (95% CI 30.3-37.9) per 100 admissions.\n\nRAD tests enabled prompt detection of SARS-CoV-2 infection which had pronounced effects on LoS at the ED. Negative VitaPCR enabled cessation of IPC measures and a negative test was associated with increased targeted admissions, reduced intrahospital transfers and shorter LoS at the hospital.", "doi": "10.1186/s12879-022-07497-x", "pmid": "35692041", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12879-022-07497-x"}], "notes": [], "created": "2022-06-20T18:21:13.398Z", "modified": "2022-06-20T18:21:13.445Z"}, {"entity": "publication", "iuid": "6ae19140f6104a0983b7bb365708ad21", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ae19140f6104a0983b7bb365708ad21.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ae19140f6104a0983b7bb365708ad21"}}, "title": "aMMP-8 Oral Fluid PoC Test in Relation to Oral and Systemic Diseases.", "authors": [{"family": "Sorsa", "given": "Timo", "initials": "T"}, {"family": "Nwhator", "given": "Solomon Olusegun", "initials": "SO"}, {"family": "Sakellari", "given": "Dimitra", "initials": "D"}, {"family": "Grigoriadis", "given": "Andreas", "initials": "A"}, {"family": "Umeizudike", "given": "Kehinde Adesola", "initials": "KA"}, {"family": "Brandt", "given": "Ella", "initials": "E"}, {"family": "Keskin", "given": "Mutlu", "initials": "M"}, {"family": "Tervahartiala", "given": "Taina", "initials": "T"}, {"family": "P\u00e4rn\u00e4nen", "given": "Pirjo", "initials": "P"}, {"family": "Gupta", "given": "Shipra", "initials": "S"}, {"family": "Mohindra", "given": "Ritin", "initials": "R"}, {"family": "Bostanci", "given": "Nagihan", "initials": "N"}, {"family": "Buduneli", "given": "Nurcan", "initials": "N"}, {"family": "R\u00e4is\u00e4nen", "given": "Ismo Tapani", "initials": "IT"}], "type": "journal article", "published": "2022-06-10", "journal": {"title": "Front Oral Health", "issn": "2673-4842", "volume": "3", "pages": "897115", "issn-l": null}, "abstract": "The manuscript uses the previously published literature and highlights the benefits of active-matrix metalloproteinase (aMMP)-8 chairside/point-of-care (PoC) diagnostic tools as adjunctive measures in oral and systemic diseases. Previous studies suggest that as a biomarker, aMMP-8 is more precise than total MMP-8, MMP-9, MMP-2, MMP-3, MMP-13, MMP-7, MMP-1, calprotectin, myeloperoxidase (MPO), human neutrophil elastase (HNE), tissue inhibitor of matrix metalloproteinase (TIMP)-1, and bleeding of probing (BOP). Therefore, aMMP-8 could be implemented as the needed key biomarker for the new disease classification for both periodontitis and peri-implantitis. With a sensitivity to the tune of 75-85% and specificity in the range of 80-90%, lateral flow aMMP-8 PoC testing is comparable to catalytic protease activity assays for aMMP-8. The test can be further applied to estimate the glycemic status of an individual, to ascertain whether a person is at risk for COVID-19, in managing the oral side effects of radiotherapy carried in head and neck cancers, and in selected cases pertaining to reproductive health. In the future, aMMP-8 could find application as a potential systemic biomarker in diseases affecting the cardiovascular system, cancers, bacteremia, sepsis, diabetes, obesity, meningitis, as well as pancreatitis. The aMMP-8 PoCT is the first practical test in the emerging new dental clinical field, that is, oral clinical chemistry representing oral medicine, clinical chemistry, peri-implantology, and periodontology.", "doi": "10.3389/froh.2022.897115", "pmid": "35757444", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC9226345"}], "notes": [], "created": "2022-08-19T05:38:03.867Z", "modified": "2022-08-19T05:38:03.904Z"}, {"entity": "publication", "iuid": "55689f4f9c6540d888c7715314d2a70d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/55689f4f9c6540d888c7715314d2a70d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/55689f4f9c6540d888c7715314d2a70d"}}, "title": "Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination.", "authors": [{"family": "Scutelnic", "given": "Adrian", "initials": "A", "orcid": "0000-0001-9053-584X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c03804e51e6434382ecafddecb77bf0.json"}}, {"family": "Krzywicka", "given": "Katarzyna", "initials": "K"}, {"family": "Mbroh", "given": "Joshua", "initials": "J", "orcid": "0000-0002-0108-9161", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44e989b3250f44ba8d76c9998461cea2.json"}}, {"family": "van de Munckhof", "given": "Anita", "initials": "A"}, {"family": "S\u00e1nchez van Kammen", "given": "Mayte", "initials": "M", "orcid": "0000-0001-5614-9689", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae4f548088eb4c099837e35267755c0b.json"}}, {"family": "Aguiar de Sousa", "given": "Diana", "initials": "D"}, {"family": "Lindgren", "given": "Erik", "initials": "E", "orcid": "0000-0002-7628-5044", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e973b3c74ff4e5cba42da605a13bc61.json"}}, {"family": "Jood", "given": "Katarina", "initials": "K"}, {"family": "G\u00fcnther", "given": "Albrecht", "initials": "A"}, {"family": "Hiltunen", "given": "Sini", "initials": "S"}, {"family": "Putaala", "given": "Jukka", "initials": "J", "orcid": "0000-0002-6630-6104", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1930f3c097044b3a00d888744dab332.json"}}, {"family": "Tiede", "given": "Andreas", "initials": "A"}, {"family": "Maier", "given": "Frank", "initials": "F"}, {"family": "Kern", "given": "Rolf", "initials": "R"}, {"family": "Bartsch", "given": "Thorsten", "initials": "T"}, {"family": "Althaus", "given": "Katharina", "initials": "K"}, {"family": "Ciccone", "given": "Alfonso", "initials": "A"}, {"family": "Wiedmann", "given": "Markus", "initials": "M"}, {"family": "Skjelland", "given": "Mona", "initials": "M"}, {"family": "Medina", "given": "Antonio", "initials": "A"}, {"family": "Cuadrado-Godia", "given": "Elisa", "initials": "E"}, {"family": "Cox", "given": "Thomas", "initials": "T"}, {"family": "Aujayeb", "given": "Avinash", "initials": "A"}, {"family": "Raposo", "given": "Nicolas", "initials": "N", "orcid": "0000-0002-9152-4445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e10b5314fc94454b9c9c93eda229c6ff.json"}}, {"family": "Garambois", "given": "Katia", "initials": "K"}, {"family": "Payen", "given": "Jean-Francois", "initials": "JF"}, {"family": "Vuillier", "given": "Fabrice", "initials": "F"}, {"family": "Franchineau", "given": "Guillaume", "initials": "G"}, {"family": "Timsit", "given": "Serge", "initials": "S", "orcid": "0000-0003-0346-8576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7082d2f62ee47dd930342533b8841cf.json"}}, {"family": "Bougon", "given": "David", "initials": "D"}, {"family": "Dubois", "given": "Marie-C\u00e9cile", "initials": "MC"}, {"family": "Tawa", "given": "Audrey", "initials": "A"}, {"family": "Tracol", "given": "Clement", "initials": "C"}, {"family": "De Maistre", "given": "Emmanuel", "initials": "E"}, {"family": "Bonneville", "given": "Fabrice", "initials": "F"}, {"family": "Vayne", "given": "Caroline", "initials": "C"}, {"family": "Mengel", "given": "Annerose", "initials": "A"}, {"family": "Michalski", "given": "Dominik", "initials": "D"}, {"family": "Pelz", "given": "Johann", "initials": "J"}, {"family": "Wittstock", "given": "Matthias", "initials": "M"}, {"family": "Bode", "given": "Felix", "initials": "F"}, {"family": "Zimmermann", "given": "Julian", "initials": "J"}, {"family": "Schouten", "given": "Judith", "initials": "J"}, {"family": "Buture", "given": "Alina", "initials": "A"}, {"family": "Murphy", "given": "Sean", "initials": "S"}, {"family": "Palma", "given": "Vincenzo", "initials": "V", "orcid": "0000-0002-5178-7793", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/917551b107984115bd6544b5079a56d1.json"}}, {"family": "Negro", "given": "Alberto", "initials": "A"}, {"family": "Gutschalk", "given": "Alexander", "initials": "A"}, {"family": "Nagel", "given": "Simon", "initials": "S"}, {"family": "Schoenenberger", "given": "Silvia", "initials": "S", "orcid": "0000-0002-3348-6719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d55b87b9e7b94c0e936017c09d2f4113.json"}}, {"family": "Frisullo", "given": "Giovanni", "initials": "G"}, {"family": "Zanferrari", "given": "Carla", "initials": "C"}, {"family": "Grillo", "given": "Francesco", "initials": "F"}, {"family": "Giammello", "given": "Fabrizio", "initials": "F", "orcid": "0000-0002-2828-1305", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15fc1c416e354e57aa7e27beca2c5288.json"}}, {"family": "Martin", "given": "Mar Morin", "initials": "MM"}, {"family": "Cervera", "given": "Alvaro", "initials": "A"}, {"family": "Burrow", "given": "Jim", "initials": "J"}, {"family": "Garcia Esperon", "given": "Carlos", "initials": "C", "orcid": "0000-0001-8843-5890", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09472127f9334b0683793dd810154088.json"}}, {"family": "Chew", "given": "Beng Lim Alvin", "initials": "BLA"}, {"family": "Kleinig", "given": "Timothy J", "initials": "TJ"}, {"family": "Soriano", "given": "Cristina", "initials": "C"}, {"family": "Zimatore", "given": "Domenico S", "initials": "DS"}, {"family": "Petruzzellis", "given": "Marco", "initials": "M"}, {"family": "Elkady", "given": "Ahmed", "initials": "A"}, {"family": "Miranda", "given": "Miguel S", "initials": "MS"}, {"family": "Fernandes", "given": "Jo\u00e3o", "initials": "J"}, {"family": "Hellstr\u00f6m Vogel", "given": "\u00c5sl\u00f6g", "initials": "\u00c5"}, {"family": "Johansson", "given": "Elias", "initials": "E"}, {"family": "Philip", "given": "Anemon Puthuppallil", "initials": "AP"}, {"family": "Coutts", "given": "Shelagh B", "initials": "SB"}, {"family": "Bal", "given": "Simerpreet", "initials": "S"}, {"family": "Buck", "given": "Brian", "initials": "B"}, {"family": "Legault", "given": "Catherine", "initials": "C"}, {"family": "Blacquiere", "given": "Dylan", "initials": "D"}, {"family": "Katzberg", "given": "Hans D", "initials": "HD"}, {"family": "Field", "given": "Thalia S", "initials": "TS"}, {"family": "Dizonno", "given": "Vanessa", "initials": "V"}, {"family": "Gattringer", "given": "Thomas", "initials": "T", "orcid": "0000-0002-6065-6576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08316e418e954e04b10df2f202714764.json"}}, {"family": "Jacobi", "given": "Christian", "initials": "C"}, {"family": "Devroye", "given": "Annemie", "initials": "A"}, {"family": "Lemmens", "given": "Robin", "initials": "R"}, {"family": "Kristoffersen", "given": "Espen Saxhaug", "initials": "ES", "orcid": "0000-0002-8999-5424", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73de5b72e1914dc7a18152e46ac4befc.json"}}, {"family": "Bandettini di Poggio", "given": "Monica", "initials": "M"}, {"family": "Ghiasian", "given": "Masoud", "initials": "M"}, {"family": "Karapanayiotides", "given": "Theodoros", "initials": "T"}, {"family": "Chatterton", "given": "Sophie", "initials": "S"}, {"family": "Wronski", "given": "Miriam", "initials": "M"}, {"family": "Ng", "given": "Karl", "initials": "K"}, {"family": "Kahnis", "given": "Robert", "initials": "R"}, {"family": "Geeraerts", "given": "Thomas", "initials": "T"}, {"family": "Reiner", "given": "Peggy", "initials": "P"}, {"family": "Cordonnier", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-5697-6892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba080d69348640eb90fba290f58fee11.json"}}, {"family": "Middeldorp", "given": "Saskia", "initials": "S"}, {"family": "Levi", "given": "Marcel", "initials": "M"}, {"family": "van Gorp", "given": "Eric C M", "initials": "ECM"}, {"family": "van de Beek", "given": "Diederik", "initials": "D"}, {"family": "Brodard", "given": "Justine", "initials": "J"}, {"family": "Kremer Hovinga", "given": "Johanna A", "initials": "JA"}, {"family": "Kruip", "given": "Marieke J H A", "initials": "MJHA"}, {"family": "Tatlisumak", "given": "Turgut", "initials": "T"}, {"family": "Ferro", "given": "Jos\u00e9 M", "initials": "JM"}, {"family": "Coutinho", "given": "Jonathan M", "initials": "JM"}, {"family": "Arnold", "given": "Marcel", "initials": "M"}, {"family": "Poli", "given": "Sven", "initials": "S"}, {"family": "Heldner", "given": "Mirjam R", "initials": "MR", "orcid": "0000-0002-3594-2159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8280f8c6ea3a486abae8acc6aa491985.json"}}], "type": "journal article", "published": "2022-06-10", "journal": {"title": "Ann Neurol", "issn": "1531-8249", "issn-l": null}, "abstract": "Cerebral venous thrombosis caused by vaccine-induced immune thrombotic thrombocytopenia (VITT-CVT) is a rare adverse effect of adenovirus-based SARS-CoV-2 vaccines. In March 2021, after autoimmune pathogenesis of VITT was discovered, treatment recommendations were developed. These comprised immunomodulation, non-heparin anticoagulants, and avoidance of platelet transfusion. The aim of this study was to evaluate adherence to these recommendations and its association with mortality.\n\nWe used data from an international prospective registry of patients with CVT after adenovirus-based SARS-CoV-2 vaccination. We analyzed possible, probable or definite VITT-CVT cases included until 18 January 2022. Immunomodulation entailed administration of intravenous immunoglobulins and/or plasmapheresis.\n\n99 VITT-CVT patients from 71 hospitals in 17 countries were analyzed. Five of 38 (13%), 11/24 (46%), and 28/37 (76%) of patients diagnosed in March, April, and from May onwards, respectively, were treated in-line with VITT recommendations (p<0.001). Overall, treatment according to recommendations had no statistically significant influence on mortality (14/44 (32%) vs 29/55 (52%), adjusted OR 0.43 (95%CI 0.16-1.19)). However, patients who received immunomodulation had lower mortality (19/65 (29%) vs 24/34 (70%), adjusted OR 0.19 (95%CI 0.06-0.58)). Treatment with non-heparin anticoagulants instead of heparins was not associated with lower mortality (17/51 (33%) vs 13/35 (37%), adjusted OR 0.70 (95%CI 0.24-2.04)). Mortality was also not significantly influenced by platelet transfusion (17/27 (63%) vs 26/72 (36%), adjusted OR 2.19 (95%CI 0.74-6.54)).\n\nIn VITT-CVT patients, adherence to VITT treatment recommendations improved over time. Immunomodulation seems crucial for reducing mortality of VITT-CVT. This article is protected by copyright. All rights reserved.", "doi": "10.1002/ana.26431", "pmid": "35689346", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-20T19:24:43.957Z", "modified": "2022-06-20T19:24:55.082Z"}, {"entity": "publication", "iuid": "213af95fecd449bb8691218aa8923c26", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/213af95fecd449bb8691218aa8923c26.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/213af95fecd449bb8691218aa8923c26"}}, "title": "Seven domains of persisting problems after hospital-treated Covid-19 indicate a need for a multiprofessional rehabilitation approach.", "authors": [{"family": "Hellgren", "given": "Lovisa", "initials": "L"}, {"family": "Levi", "given": "Richard", "initials": "R"}, {"family": "Divanoglou", "given": "Anestis", "initials": "A"}, {"family": "Birberg-Thornberg", "given": "Ulrika", "initials": "U"}, {"family": "Samuelsson", "given": "Kersti", "initials": "K"}], "type": "journal article", "published": "2022-06-09", "journal": {"title": "J Rehabil Med", "issn": "1651-2081", "issn-l": null}, "abstract": "Objectives To identify domains of persisting problems at 4 months after discharge in patients previously hospitalized due to COVID-19, with focus on the subgroup of patients reporting symptoms to an extent indicative of rehabilitation needs. Design Ambidirectional observational cohort study. Patients All patients with a laboratory-confirmed COVID-19 diagnosis admitted to hospital in a Swedish healthcare region during 1/03-31/05, 2020. After exclusion, 94% of all survivors (n=433) participated in the study. Forty-three percent (n=185) of these reported persisting problems indicating rehabilitation needs and formed a subgroup. Methods Explorative factor analysis based on results from comprehensive telephone interviews covering persisting symptoms, including assessment of impact in daily life. Results Seven domains were identified comprising problems related to vision, cognition, mental fatigue, swallowing, voice, sensorimotor dysfunction and feeling anxious/depressed. The patients in the subgroup reported a median of 8 symptoms/limitations affecting everyday life, and two thirds reported symptoms/limitations in three or more domains. Conclusions Seven problem domains corresponding to specific modalities of rehabilitative interventions were identified. As a majority of patients reported problems from several domains, multiprofessional teams in post-COVID-19 rehabilitation is implicated. Screening of patients previously hospitalized due to COVID-19 should cover all seven domains.", "doi": "10.2340/jrm.v54.2434", "pmid": "35678268", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-20T19:29:58.865Z", "modified": "2022-06-20T19:29:58.879Z"}, {"entity": "publication", "iuid": "9350efb6514a4278a52e306bfaf61a81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9350efb6514a4278a52e306bfaf61a81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9350efb6514a4278a52e306bfaf61a81"}}, "title": "Pre-pandemic Physical Function and Social Network in Relation to COVID-19-Associated Depressive Burden in Older Adults in Sweden.", "authors": [{"family": "Triolo", "given": "Federico", "initials": "F", "orcid": "0000-0002-8732-0036", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a5b676e886a4723942f5bbf96a4e4d8.json"}}, {"family": "Saadeh", "given": "Marguerita", "initials": "M", "orcid": "0000-0002-2689-5784", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/324dbc9ae7ec4e5daab17e7fab6a183c.json"}}, {"family": "Sj\u00f6berg", "given": "Linnea", "initials": "L"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Welmer", "given": "Anna-Karin", "initials": "AK", "orcid": "0000-0001-5819-8724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d248c60e17b48cfa3ea3e90abf1e710.json"}}, {"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A"}, {"family": "Dekhtyar", "given": "Serhiy", "initials": "S", "orcid": "0000-0002-3062-4848", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9767e9072f6a44f6853b4001340eee97.json"}}], "type": "journal article", "published": "2022-06-09", "journal": {"title": "Innov Aging", "issn": "2399-5300", "volume": "6", "issue": "5", "pages": "igac041", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic, as well as the measures intended to limit its spread, have likely affected older adults' depressive burden. Good physical functioning and a rich social network may benefit older adults' mental health. We examined whether pre-pandemic physical functioning and social network were associated with depressive burden during the first wave of the COVID-19 pandemic in Stockholm, Sweden.\n\nA telephone assessment of depressive burden using the symptoms of sadness, anxiety, worrying, reduced sleep, and reduced appetite was conducted in May-September 2020 in 930 older adults from the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K), an ongoing population-based study. Objective measures of gait speed, muscle strength, and balance; and self-reports of social connections and support were collected in 2016-2019. Logistic models were adjusted for sociodemographic, clinical, lifestyle, and pandemic-related factors (loneliness, change in physical and social engagement, and experience of death due to COVID-19).\n\nOnly good muscle strength (odds ratio [OR]: 0.53; 95% confidence interval [CI]: 0.32-0.85; ref: poor strength, \u226517 s) and rich social support (OR: 0.67; 95% CI: 0.45-0.99; ref: poor support) exhibited an independent association with depressive burden, even after accounting for pandemic-related factors. A combination of good muscle strength and rich social support were associated with the greatest reduction in depressive burden (OR: 0.35; 95% CI: 0.18-0.66; ref: poor social support and poor muscle strength).\n\nPrepandemic social support and muscle strength could supply older adults with resilience against the depressive burden associated with the COVID-19 pandemic.", "doi": "10.1093/geroni/igac041", "pmid": "35837440", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "igac041"}, {"db": "pmc", "key": "PMC9273957"}], "notes": [], "created": "2022-08-12T08:58:51.049Z", "modified": "2022-08-12T08:58:51.257Z"}, {"entity": "publication", "iuid": "d4ae1d7ec5f7481e9c9095dfeaf9e0e5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4ae1d7ec5f7481e9c9095dfeaf9e0e5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4ae1d7ec5f7481e9c9095dfeaf9e0e5"}}, "title": "In Vivo Visualization and Quantification of Neutrophil Elastase in Lungs of COVID-19 Patients - A First-In-Human Positron Emission Tomography Study with 11C-GW457427.", "authors": [{"family": "Antoni", "given": "Gunnar", "initials": "G"}, {"family": "Lubberink", "given": "Mark", "initials": "M"}, {"family": "S\u00f6rensen", "given": "Jens", "initials": "J"}, {"family": "Lindstr\u00f6m", "given": "Elin", "initials": "E"}, {"family": "Elgland", "given": "Mathias", "initials": "M"}, {"family": "Eriksson", "given": "Olof", "initials": "O"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Wanhainen", "given": "Anders", "initials": "A"}, {"family": "Sigfridsson", "given": "Jonathan", "initials": "J"}, {"family": "Skorup", "given": "Paul", "initials": "P"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}], "type": "journal article", "published": "2022-06-09", "journal": {"title": "J Nucl Med", "issn": "1535-5667", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "COVID-19 can cause life-threatening lung-inflammation that is suggested to be mediated by neutrophils, whose effector mechanisms in COVID-19 is inexplicit. The aim of the present work is to evaluate a novel PET tracer for neutrophil elastase in COVID-19 patients and healthy controls. METHODS: In this open-label, First-In-Man study, four patients with hypoxia due to COVID-19 and two healthy controls were investigated with positron emission tomography (PET) using the new selective and specific neutrophil elastase PET-tracer [11C]GW457427 and [15O]water for the visualization and quantification of NE and perfusion in the lungs, respectively. RESULTS: [11C]GW457427 accumulated selectively in lung areas with ground-glass opacities on computed tomography characteristic of COVID-19 suggesting high levels on NE in these areas. In the same areas perfusion was severely reduced in comparison to healthy lung tissue as measured with [15O]water. CONCLUSION: The data suggests that NE may be responsible for the severe lung inflammation in COVID-19 patients and that inhibition of NE could potentially reduce the acute inflammatory process and improve the condition.", "doi": "10.2967/jnumed.122.263974", "pmid": "35680418", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "jnumed.122.263974"}], "notes": [], "created": "2022-06-20T19:28:49.814Z", "modified": "2022-08-19T12:36:21.106Z"}, {"entity": "publication", "iuid": "5251c54c69ab46da86cb75a58d411edb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5251c54c69ab46da86cb75a58d411edb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5251c54c69ab46da86cb75a58d411edb"}}, "title": "Age and sex effects on DNA methylation sites linked to genes implicated in severe COVID-19 and SARS-CoV-2 host cell entry.", "authors": [{"family": "Bohlin", "given": "Jon", "initials": "J", "orcid": "0000-0002-0992-1311", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20544b4db3c44a34b7f11715729e927d.json"}}, {"family": "Page", "given": "Christian M", "initials": "CM", "orcid": "0000-0002-1897-3666", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82db13fac79542f6be91580db5e15f64.json"}}, {"family": "Lee", "given": "Yunsung", "initials": "Y"}, {"family": "Pettersson", "given": "John H-O", "initials": "JH", "orcid": "0000-0001-6665-7492", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59b007230a6741888ef96de5e210276c.json"}}, {"family": "Jugessur", "given": "Astanand", "initials": "A"}, {"family": "Magnus", "given": "Per", "initials": "P"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}], "type": "journal article", "published": "2022-06-09", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "6", "pages": "e0269105", "issn-l": "1932-6203"}, "abstract": "Male sex and advanced age are associated with severe symptoms of COVID-19. Sex and age also exhibit substantial associations with genome-wide DNA methylation (DNAm) differences in humans. Using a random sample of Illumina EPIC-based genome-wide methylomes from peripheral whole blood of 1,976 parents, participating in The Norwegian Mother, Father and Child Cohort Study (MoBa), we explored whether DNAm in genes linked to SARS-CoV-2 host cell entry and to severe COVID-19 were associated with sex and age. This was carried out by testing 1,572 DNAm sites (CpGs) located near 45 genes for associations with age and sex. We found that DNAm in 281 and 231 of 1,572 CpGs were associated (pFDR<0.01) with sex and aging, respectively. CpGs linked to SARS-CoV-2 host cell entry genes were all associated with age and sex, except for the ACE2 receptor gene (located on the X-chromosome), which was only associated with sex (pFDR<0.01). Furthermore, we examined whether 1,487 autosomal CpGs associated with host-cell entry and severe COVID-19 were more or less associated with sex and age than what would be expected from the same number of randomly sampled genome-wide CpGs. We found that the CpGs associated with host-cell entry and severe COVID-19 were not more or less associated with sex (R2 = 0.77, p = 0.09) than the CpGs sampled from random genomic regions; age was actually found to be significantly less so (R2 = 0.36, p = 0.04). Hence, while we found wide-spread associations between sex and age at CpGs linked to genes implicated with SARS-CoV-2 host cell entry and severe COVID-19, the effect from the sum of these CpGs was not stronger than that from randomly sampled CpGs; for age it was significantly less so. These findings could suggest that advanced age and male sex may not be unsurmountable barriers for the SARS-CoV-2 virus to evolve increased infectiousness.", "doi": "10.1371/journal.pone.0269105", "pmid": "35679253", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-27385"}], "notes": [], "created": "2022-06-20T19:29:30.046Z", "modified": "2022-06-20T19:29:30.205Z"}, {"entity": "publication", "iuid": "d1dde5aa6de64fe2b824de24260f6fd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1dde5aa6de64fe2b824de24260f6fd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1dde5aa6de64fe2b824de24260f6fd0"}}, "title": "Synthesizing Stakeholders Perspectives on Online Psychological Interventions to Improve the Mental Health of the Italian Population during the COVID-19 Pandemic: An Online Survey Study.", "authors": [{"family": "Bertuzzi", "given": "Vanessa", "initials": "V", "orcid": "0000-0002-8541-5357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7abc069e75034b0e96265c7d48fb95a2.json"}}, {"family": "Semonella", "given": "Michelle", "initials": "M"}, {"family": "Castelnuovo", "given": "Gianluca", "initials": "G", "orcid": "0000-0003-2633-9822", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7463db589ae343e5ae6a7bc47a917c22.json"}}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Pietrabissa", "given": "Giada", "initials": "G"}], "type": "journal article", "published": "2022-06-08", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "12", "issn-l": null}, "abstract": "The COVID-19 pandemic is expected to significantly increase the prevalence of mental health problems, thus raising the need for psychological support interventions around the world. Online psychological interventions have already been shown to be an effective solution to promote psychological treatments. Nevertheless, planning and developing an online intervention, involving possible stakeholders, might facilitate the dissemination of, willingness to use, and success of the future intervention. This study aims to explore and compare the experiences that Italians living in Italy and abroad had with available support services during the COVID-19 pandemic, their needs, and attitudes, as well as possible barriers to online psychological interventions. A sample of 1024 Italians (F = 69.8%; mean age = 41.3; SD = 15.3) was recruited through social media platforms and personal contacts and they were asked to complete an online survey. Results showed that perceived psychological distress during the COVID-19 pandemic improved. In Europe, psychological support was delivered mainly in person (69.0%), while online interventions were primarily used in extra-European countries (57%). Then, only 44% of the total sample was interested in trying an online psychological intervention. Various advantages and disadvantages were defined by stakeholders: The main advantages were the reduction in geographical distances, economic reasons, and the reduction in the waiting list; The main disadvantages were problems with technology, low motivation of users, and privacy/safety reasons. These data made it possible to improve the knowledge regarding the views and attitudes that Italians have about online psychological interventions, and shed light on how to increase the uptake of digital health.", "doi": "10.3390/ijerph19127008", "pmid": "35742257", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19127008"}, {"db": "pmc", "key": "PMC9222987"}], "notes": [], "created": "2022-08-19T05:46:23.067Z", "modified": "2022-08-19T05:47:08.175Z"}, {"entity": "publication", "iuid": "f2fc843354aa430c8c48e3c815fcfd04", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f2fc843354aa430c8c48e3c815fcfd04.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f2fc843354aa430c8c48e3c815fcfd04"}}, "title": "Perceptions of delay when afflicted by an acute myocardial infarction during the first wave of the COVID-19 pandemic.", "authors": [{"family": "Granstr\u00f6m", "given": "Johanna", "initials": "J", "orcid": "0000-0002-3895-3179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/577ea5c47de04511a9b34e470c4d8b67.json"}}, {"family": "Lantz", "given": "Pontus", "initials": "P", "orcid": "0000-0003-4037-3904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6754b9ed3cd45129f456eab5c1e27c2.json"}}, {"family": "Lidin", "given": "Matthias", "initials": "M", "orcid": "0000-0002-2297-5621", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/99c36a92228c473dbebfce62830d2f35.json"}}, {"family": "Wahlstr\u00f6m", "given": "Maria", "initials": "M", "orcid": "0000-0003-4339-9202", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d169b22b55c4b11aa7b13f718f5f97b.json"}}, {"family": "Nymark", "given": "Carolin", "initials": "C", "orcid": "0000-0003-0891-6358", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26ae7dfc5d824e6ba7fda3c21ac670ef.json"}}], "type": "journal article", "published": "2022-06-08", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "issn-l": null}, "abstract": "To describe the perceptions of delay in medical care-seeking, when afflicted by an acute myocardial infarction (AMI) during the first wave of the pandemic.\n\nA qualitative descriptive study with an inductive approach. Fourteen semi-structured interviews were conducted, analysed by qualitative content analysis with a manifest approach. One category and six sub-categories emerged. The decision was reached when the health threat was perceived as critical, which made the earlier thoughts of the pandemic fade away. The risk of infection during medical visits caused fear of contracting the disease. This resulted in hesitation, neglect of symptoms, and avoidance of healthcare visits. Following recommendations from authorities and media about personal responsibility was motivated by fear, affecting the care-seeking.\n\nIt appears that the COVID-19 pandemic raised the threshold for deciding to seek medical care when presenting with an AMI. The pandemic led to increased patient delay due to several reasons among which fear of contracting the disease was prominent. The emotion of fear was related to the external threat to one's own health, due to COVID-19, and not fear of symptoms related to an AMI. The media reporting the healthcare system as overloaded increased insecurity and may have had an influence on delay.", "doi": "10.1093/eurjcn/zvac021", "pmid": "35672906", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6603987"}], "notes": [], "created": "2022-06-20T19:31:19.093Z", "modified": "2022-06-20T19:31:31.810Z"}, {"entity": "publication", "iuid": "35522c10f3744041bf3b7022dcbaeb94", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/35522c10f3744041bf3b7022dcbaeb94.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/35522c10f3744041bf3b7022dcbaeb94"}}, "title": "Pandemetrics: systematically assessing, monitoring, and controlling the evolution of a pandemic.", "authors": [{"family": "Barone", "given": "Stefano", "initials": "S", "orcid": "0000-0002-0339-8435", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7da10883e83473e955b7894ad37b7e8.json"}}, {"family": "Chakhunashvili", "given": "Alexander", "initials": "A"}], "type": "journal article", "published": "2022-06-08", "journal": {"title": "Qual Quant", "issn": "0033-5177", "pages": "1-23", "issn-l": null}, "abstract": "The still ongoing pandemic of SARS-CoV-2 virus and COVID-19 disease, affecting the population worldwide, has demonstrated the need of more accurate methodologies for assessing, monitoring, and controlling an outbreak of such devastating proportions. Authoritative attempts have been made in traditional fields of medicine (epidemiology, virology, infectiology) to address these shortcomings, mainly by relying on mathematical and statistical modeling. However, here, we propose approaching the methodological work from a different, and to some extent alternative, standpoint. Applied systematically, the concepts and tools of statistical engineering and quality management, developed not only in healthcare settings, but also in other scientific contexts, can be very useful in assessing, monitoring, and controlling pandemic events. We propose a methodology based on a set of tools and techniques, formulas, graphs, and tables to support the decision-making concerning the management of a pandemic like COVID-19. This methodological body is hereby named Pandemetrics. This name intends to emphasize the peculiarity of our approach to measuring, and graphically presenting the unique context of the COVID-19 pandemic.", "doi": "10.1007/s11135-022-01424-7", "pmid": "35694109", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "1424"}, {"db": "pmc", "key": "PMC9174634"}], "notes": [], "created": "2022-06-20T18:19:25.551Z", "modified": "2022-06-20T18:19:25.628Z"}, {"entity": "publication", "iuid": "b1d98ccebcc9452f911869284786638e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1d98ccebcc9452f911869284786638e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1d98ccebcc9452f911869284786638e"}}, "title": "Incidence and severity of SARS-CoV-2 infection in former Q fever patients as compared to the Dutch population, 2020-2021.", "authors": [{"family": "den Boogert", "given": "Elisabeth Maria", "initials": "EM", "orcid": "0000-0003-4514-0026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb49158a9d6e43429ef9622f2712b614.json"}}, {"family": "de Lange", "given": "Marit M A", "initials": "MMA"}, {"family": "Wielders", "given": "Cornelia C H", "initials": "CCH", "orcid": "0000-0002-2413-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5b6b985406d4b43ac66c6336dd1e4fe.json"}}, {"family": "Rietveld", "given": "Ariene", "initials": "A"}, {"family": "RIVM COVID-19 Surveillance and Epidemiology Team", "given": "", "initials": ""}, {"family": "Knol", "given": "Mirjam J", "initials": "MJ"}, {"family": "van Gageldonk-Lafeber", "given": "Arianne B", "initials": "AB"}], "type": "journal article", "published": "2022-06-08", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": "150", "pages": "e116", "issn-l": null}, "abstract": "Surveillance data shows a geographical overlap between the early coronavirus disease 2019 (COVID-19) pandemic and the past Q fever epidemic (2007-2010) in the Netherlands. We investigated the relationship between past Q fever and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in 2020/2021, using a retrospective matched cohort study.In January 2021, former Q fever patients received a questionnaire on demographics, SARS-CoV-2 test results and related hospital/intensive care unit (ICU) admissions. SARS-CoV-2 incidence with 95% confidence intervals (CI) in former Q fever patients and standardised incidence ratios (SIR) to compare to the age-standardised SARS-CoV-2 incidence in the general regional population were calculated.Among 890 former Q fever patients (response rate: 68%), 66 had a PCR-confirmed SARS-CoV-2 infection. Of these, nine (14%) were hospitalised and two (3%) were admitted to ICU. From February to June 2020 the SARS-CoV-2 incidence was 1573/100 000 (95% CI 749-2397) in former Q fever patients and 695/100 000 in the general population (SIR 2.26; 95% CI 1.24-3.80). The incidence was not significantly higher from September 2020 to February 2021.We found no sufficient evidence for a difference in SARS-CoV-2 incidence or an increased severity in former Q fever patients vs. the general population during the period with widespread SARS-CoV-2 testing availability (September 2020-February 2021). This indicates that former Q fever patients do not have a higher risk of SARS-CoV-2 infection.", "doi": "10.1017/S0950268822001029", "pmid": "35730315", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0950268822001029"}, {"db": "pmc", "key": "PMC9237486"}], "notes": [], "created": "2022-08-17T13:06:21.531Z", "modified": "2022-08-17T13:06:21.622Z"}, {"entity": "publication", "iuid": "c7207f8b8ccf44f4a2dd7d2a19c2e6b8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7207f8b8ccf44f4a2dd7d2a19c2e6b8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7207f8b8ccf44f4a2dd7d2a19c2e6b8"}}, "title": "COVID-19 news and the US equity market interactions: An inspection through econometric and machine learning lens.", "authors": [{"family": "Jana", "given": "Rabin K", "initials": "RK"}, {"family": "Ghosh", "given": "Indranil", "initials": "I"}, {"family": "Jawadi", "given": "Fredj", "initials": "F", "orcid": "0000-0003-3655-8391", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a38cc17b4a74cc895fcdb29dcd4a8b3.json"}}, {"family": "Uddin", "given": "Gazi Salah", "initials": "GS"}, {"family": "Sousa", "given": "Ricardo M", "initials": "RM"}], "type": "news", "published": "2022-06-08", "journal": {"title": "Ann Oper Res", "issn": "0254-5330", "issn-l": null, "volume": null, "issue": null, "pages": "1-22"}, "abstract": "This study investigates the impact of COVID-19 on the US equity market during the first wave of Coronavirus using a wide range of econometric and machine learning approaches. To this end, we use both daily data related to the US equity market sectors and data about the COVID-19 news over January 1, 2020-March 20, 2020. Accordingly, we show that at an early stage of the outbreak, global COVID-19s fears have impacted the US equity market even differently across sectors. Further, we also find that, as the pandemic gradually intensified its footprint in the US, local fears manifested by daily infections emerged more powerfully compared to its global counterpart in impairing the short-term dynamics of US equity markets.", "doi": "10.1007/s10479-022-04744-x", "pmid": "35698596", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "4744"}, {"db": "pmc", "key": "PMC9175525"}], "notes": [], "created": "2022-06-20T18:17:51.292Z", "modified": "2022-11-09T08:41:00.145Z"}, {"entity": "publication", "iuid": "6b3870582e3b46aca03e66295d52f284", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b3870582e3b46aca03e66295d52f284.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b3870582e3b46aca03e66295d52f284"}}, "title": "Understanding the Role and Impact of Poly (Ethylene Glycol) (PEG) on Nanoparticle Formulation: Implications for COVID-19 Vaccines.", "authors": [{"family": "Pad\u00edn-Gonz\u00e1lez", "given": "Esperanza", "initials": "E"}, {"family": "Lancaster", "given": "Pearl", "initials": "P"}, {"family": "Bottini", "given": "Massimo", "initials": "M"}, {"family": "Gasco", "given": "Paolo", "initials": "P"}, {"family": "Tran", "given": "Lang", "initials": "L"}, {"family": "Fadeel", "given": "Bengt", "initials": "B"}, {"family": "Wilkins", "given": "Terence", "initials": "T"}, {"family": "Monopoli", "given": "Marco P", "initials": "MP"}], "type": "journal article", "published": "2022-06-07", "journal": {"title": "Front Bioeng Biotechnol", "issn": "2296-4185", "volume": "10", "pages": "882363", "issn-l": null}, "abstract": "Poly (ethylene glycol) (PEG) is a widely used polymer in a variety of consumer products and in medicine. PEGylation refers to the conjugation of PEG to drugs or nanoparticles to increase circulation time and reduce unwanted host responses. PEG is viewed as being well-tolerated, but previous studies have identified anti-PEG antibodies and so-called pseudoallergic reactions in certain individuals. The increased use of nanoparticles as contrast agents or in drug delivery, along with the introduction of mRNA vaccines encapsulated in PEGylated lipid nanoparticles has brought this issue to the fore. Thus, while these vaccines have proven to be remarkably effective, rare cases of anaphylaxis have been reported, and this has been tentatively ascribed to the PEGylated carriers, which may trigger complement activation in susceptible individuals. Here, we provide a general overview of the use of PEGylated nanoparticles for pharmaceutical applications, and we discuss the activation of the complement cascade that might be caused by PEGylated nanomedicines for a better understanding of these immunological adverse reactions.", "doi": "10.3389/fbioe.2022.882363", "pmid": "35747492", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "882363"}, {"db": "pmc", "key": "PMC9209764"}], "notes": [], "created": "2022-08-19T05:41:06.956Z", "modified": "2022-08-19T05:41:06.990Z"}, {"entity": "publication", "iuid": "f0eee78f85084e239331766ec731525b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f0eee78f85084e239331766ec731525b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f0eee78f85084e239331766ec731525b"}}, "title": "Renin-Angiotensin Aldosterone System Inhibitors and COVID-19: A Systematic Review and Meta-Analysis Revealing Critical Bias Across a Body of Observational Research.", "authors": [{"family": "Loader", "given": "Jordan", "initials": "J", "orcid": "0000-0001-5623-7478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb84661f9eee4ff6aa5580311b1bf572.json"}}, {"family": "Taylor", "given": "Frances C", "initials": "FC"}, {"family": "Lampa", "given": "Erik", "initials": "E"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2c4588f000c470abf08f2e40852b6d1.json"}}], "type": "journal article", "published": "2022-06-07", "journal": {"title": "J Am Heart Assoc", "issn": "2047-9980", "volume": "11", "issue": "11", "pages": "e025289", "issn-l": null}, "abstract": "Background Renin-angiotensin aldosterone system (RAAS) inhibitor-COVID-19 studies, observational in design, appear to use biased methods that can distort the interaction between RAAS inhibitor use and COVID-19 risk. This study assessed the extent of bias in that research and reevaluated RAAS inhibitor-COVID-19 associations in studies without critical risk of bias. Methods and Results Searches were performed in MEDLINE, EMBASE, and CINAHL databases (December 1, 2019 to October 21, 2021) identifying studies that compared the risk of infection and/or severe COVID-19 outcomes between those using or not using RAAS inhibitors (ie, angiotensin-converting enzyme inhibitors or angiotensin II type-I receptor blockers). Weighted hazard ratios (HR) and 95% CIs were extracted and pooled in fixed-effects meta-analyses, only from studies without critical risk of bias that assessed severe COVID-19 outcomes. Of 169 relevant studies, 164 had critical risks of bias and were excluded. Ultimately, only two studies presented data relevant to the meta-analysis. In 1 351 633 people with uncomplicated hypertension using a RAAS inhibitor, calcium channel blocker, or thiazide diuretic in monotherapy, the risk of hospitalization (angiotensin-converting enzyme inhibitor: HR, 0.76; 95% CI, 0.66-0.87; P<0.001; angiotensin II type-I receptor blockers: HR, 0.86; 95% CI, 0.77-0.97; P=0.015) and intubation or death (angiotensin-converting enzyme inhibitor: HR, 0.64; 95% CI, 0.48-0.85; P=0.002; angiotensin II type-I receptor blockers: HR, 0.74; 95% CI, 0.58-0.95; P=0.019) with COVID-19 was lower in those using a RAAS inhibitor. However, these protective effects are probably not clinically relevant. Conclusions This study reveals the critical risk of bias that exists across almost an entire body of COVID-19 research, raising an important question: Were research methods and/or peer-review processes temporarily weakened during the surge of COVID-19 research or is this lack of rigor a systemic problem that also exists outside pandemic-based research? Registration URL: www.crd.york.ac.uk/prospero/; Unique identifier: CRD42021237859.", "doi": "10.1161/JAHA.122.025289", "pmid": "35624081", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T17:43:48.128Z", "modified": "2022-06-21T17:44:16.895Z"}, {"entity": "publication", "iuid": "63b3d52cc7054ddc857aefb8e82a27ec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63b3d52cc7054ddc857aefb8e82a27ec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63b3d52cc7054ddc857aefb8e82a27ec"}}, "title": "COVID-19 pandemic is associated with increased sleep disturbances and mental health symptoms but not help-seeking: a cross-sectional nation-wide study.", "authors": [{"family": "Moreno", "given": "Claudia Roberta de Castro", "initials": "CRC", "orcid": "0000-0003-1839-9673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a22ff4be344d4bb7941b0b74d4636afe.json"}}, {"family": "Conway", "given": "Silvia G", "initials": "SG"}, {"family": "Assis", "given": "M\u00e1rcia", "initials": "M"}, {"family": "Genta", "given": "Pedro Rodrigues", "initials": "PR"}, {"family": "Pachito", "given": "Daniela V", "initials": "DV"}, {"family": "Tavares", "given": "Almir", "initials": "A"}, {"family": "Sguillar", "given": "Danilo A", "initials": "DA"}, {"family": "Moreira", "given": "Gustavo", "initials": "G"}, {"family": "Drager", "given": "Luciano F", "initials": "LF"}, {"family": "Bacelar", "given": "Andrea", "initials": "A"}], "type": "journal article", "published": "2022-06-07", "journal": {"title": "Sleep Sci", "issn": "1984-0659", "volume": "15", "issue": "1", "pages": "1-7", "issn-l": null}, "abstract": "This study aimed firstly to describe sleep-related and mental health symptoms before and during the COVID-19 pandemic in a national-wide sample and, secondly, to verify attitudes towards help-seeking to treat these symptoms.\n\nData were collected through an online questionnaire sent through the Brazilian Sleep Association's social media. The questionnaire included sociodemographic and sleep aspects questions currently and before the pandemic period. In addition, the survey addressed current and previous anxiety, depression, and burnout symptoms. The outcome help-seeking was addressed in the questionnaire as well by a single question asked when the participant reported mental or sleep problems.\n\nThe study covered 6,360 participants, mean age 43.5 years (SD=14.3), 76.7% female and 63.7% with undergraduate or higher degree filled out the survey. Seventy percent of participants reported sleep disturbances and 80% reported symptoms of anxiety during the pandemic. Help-seeking behavior was found only in one third of them. Hours of sleep reduced from 7.12 to 6.2h, which can be related with the increase in 28.2% of dissatisfaction with sleep duration during the pandemic. The highest frequency of complaints related to sleep was difficulty to fall asleep three or more times a week (going from 27.6% before the pandemic to 58.9% during the pandemic; p<0.001). Moreover, it was observed that help-seeking was more prevalent in men than women, and more in younger participants than in older ones.\n\nThere was an increase of sleep and mental self-reported problems during the pandemic, which was not followed by help-seeking.", "doi": "10.5935/1984-0063.20220027", "pmid": "35662970", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9153976"}], "notes": [], "created": "2022-06-20T19:35:14.867Z", "modified": "2022-06-20T19:35:14.966Z"}, {"entity": "publication", "iuid": "a4bae0fecd924d40a9766319b6c23c26", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a4bae0fecd924d40a9766319b6c23c26.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a4bae0fecd924d40a9766319b6c23c26"}}, "title": "Associations between integrase strand-transfer inhibitors and cardiovascular disease in people living with HIV: a multicentre prospective study from the RESPOND cohort consortium.", "authors": [{"family": "Neesgaard", "given": "Bastian", "initials": "B"}, {"family": "Greenberg", "given": "Lauren", "initials": "L"}, {"family": "Mir\u00f3", "given": "Jose M", "initials": "JM"}, {"family": "Grabmeier-Pfistershammer", "given": "Katharina", "initials": "K"}, {"family": "Wandeler", "given": "Gilles", "initials": "G"}, {"family": "Smith", "given": "Colette", "initials": "C"}, {"family": "De Wit", "given": "St\u00e9phane", "initials": "S"}, {"family": "Wit", "given": "Ferdinand", "initials": "F"}, {"family": "Pelchen-Matthews", "given": "Annegret", "initials": "A"}, {"family": "Mussini", "given": "Cristina", "initials": "C"}, {"family": "Castagna", "given": "Antonella", "initials": "A"}, {"family": "Pradier", "given": "Christian", "initials": "C"}, {"family": "d'Arminio Monforte", "given": "Antonella", "initials": "A"}, {"family": "Vehreschild", "given": "J\u00f6rg J", "initials": "JJ"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Anne", "given": "Alain V", "initials": "AV"}, {"family": "Carr", "given": "Andrew", "initials": "A"}, {"family": "Bansi-Matharu", "given": "Loveleen", "initials": "L"}, {"family": "Lundgren", "given": "Jens D", "initials": "JD"}, {"family": "Garges", "given": "Harmony", "initials": "H"}, {"family": "Rogatto", "given": "Felipe", "initials": "F"}, {"family": "Zangerle", "given": "Robert", "initials": "R"}, {"family": "G\u00fcnthard", "given": "Huldrych F", "initials": "HF"}, {"family": "Rasmussen", "given": "Line D", "initials": "LD"}, {"family": "Necsoi", "given": "Coca", "initials": "C"}, {"family": "van der Valk", "given": "Marc", "initials": "M"}, {"family": "Menozzi", "given": "Marianna", "initials": "M"}, {"family": "Muccini", "given": "Camilla", "initials": "C"}, {"family": "Peters", "given": "Lars", "initials": "L"}, {"family": "Mocroft", "given": "Amanda", "initials": "A"}, {"family": "Ryom", "given": "Lene", "initials": "L"}], "type": "journal article", "published": "2022-06-07", "journal": {"title": "Lancet HIV", "issn": "2352-3018", "issn-l": null}, "abstract": "Although associations between older antiretroviral drug classes and cardiovascular disease in people living with HIV are well described, there is a paucity of data regarding a possible association with integrase strand-transfer inhibitors (INSTIs). We investigated whether exposure to INSTIs was associated with an increased incidence of cardiovascular disease.\n\nRESPOND is a prospective, multicentre, collaboration study between 17 pre-existing European and Australian cohorts and includes more than 32 000 adults living with HIV in clinical care after Jan 1, 2012. Individuals were eligible for inclusion in these analyses if they were older than 18 years, had CD4 cell counts and HIV viral load measurements in the 12 months before or within 3 months after baseline (latest of cohort enrolment or Jan 1, 2012), and had no exposure to INSTIs before baseline. These individuals were subsequently followed up to the earliest of the first cardiovascular disease event (ie, myocardial infarction, stroke, or invasive cardiovascular procedure), last follow-up, or Dec 31, 2019. We used multivariable negative binomial regression to assess associations between cardiovascular disease and INSTI exposure (0 months [no exposure] vs >0 to 6 months, >6 to 12 months, >12 to 24 months, >24 to 36 months, and >36 months), adjusted for cardiovascular risk factors. RESPOND is registered with ClinicalTrials.gov, NCT04090151, and is ongoing.\n\n29 340 people living with HIV were included in these analyses, of whom 7478 (25\u00b75%) were female, 21 818 (74\u00b74%) were male, and 44 (<1%) were transgender, with a median age of 44\u00b73 years (IQR 36\u00b72-51\u00b73) at baseline. As of Dec 31, 2019, 14 000 (47\u00b77%) of 29 340 participants had been exposed to an INSTI. During a median follow-up of 6\u00b716 years (IQR 3\u00b787-7\u00b752; 160 252 person-years), 748 (2\u00b75%) individuals had a cardiovascular disease event (incidence rate of 4\u00b767 events [95% CI 4\u00b734-5\u00b701] per 1000 person-years of follow-up). The crude cardiovascular disease incidence rate was 4\u00b719 events (3\u00b783-4\u00b757) per 1000 person-years in those with no INSTI exposure, which increased to 8\u00b746 events (6\u00b758-10\u00b771) per 1000 person-years in those with more than 0 months to 6 months of exposure, and gradually decreased with increasing length of exposure, until it decreased to similar levels of no exposure at more than 24 months of exposure (4\u00b725 events [2\u00b789-6\u00b704] per 1000 person-years among those with >24 to 36 months of exposure). Compared with those with no INSTI exposure, the risk of cardiovascular disease was increased in the first 24 months of INSTI exposure and thereafter decreased to levels similar to those never exposed (>0 to 6 months of exposure: adjusted incidence rate ratio of 1\u00b785 [1\u00b744-2\u00b739]; >6 to 12 months of exposure: 1\u00b719 [0\u00b784-1\u00b768]; >12 to 24 months of exposure: 1\u00b746 [1\u00b713-1\u00b788]; >24 to 36 months of exposure: 0\u00b789 [0\u00b762-1\u00b729]; and >36 months of exposure: 0\u00b796 [0\u00b769-1\u00b733]; p<0\u00b70001).\n\nAlthough the potential for unmeasured confounding and channelling bias cannot fully be excluded, INSTIs initiation was associated with an early onset, excess incidence of cardiovascular disease in the first 2 years of exposure, after accounting for known cardiovascular disease risk factors. These early findings call for analyses in other large studies, and the potential underlying mechanisms explored further.\n\nThe CHU St Pierre Brussels HIV Cohort, The Austrian HIV Cohort Study, The Australian HIV Observational Database, The AIDS Therapy Evaluation in the Netherlands National Observational HIV cohort, The EuroSIDA cohort, The Frankfurt HIV Cohort Study, The Georgian National AIDS Health Information System, The Nice HIV Cohort, The ICONA Foundation, The Modena HIV Cohort, The PISCIS Cohort Study, The Swiss HIV Cohort Study, The Swedish InfCare HIV Cohort, The Royal Free HIV Cohort Study, The San Raffaele Scientific Institute, The University Hospital Bonn HIV Cohort and The University of Cologne HIV Cohorts, ViiV Healthcare, and Gilead Sciences.", "doi": "10.1016/S2352-3018(22)00094-7", "pmid": "35688166", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2352-3018(22)00094-7"}, {"db": "ClinicalTrials.gov", "key": "NCT04090151"}], "notes": [], "created": "2022-06-20T19:25:55.874Z", "modified": "2022-06-20T19:25:55.914Z"}, {"entity": "publication", "iuid": "b7d2e056b4524e9ba6c651f6f889d7fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b7d2e056b4524e9ba6c651f6f889d7fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b7d2e056b4524e9ba6c651f6f889d7fc"}}, "title": "Adaptive governance of urban green spaces across Latin America ---Insights amid COVID-19.", "authors": [{"family": "Sainz-Santamaria", "given": "Jaime", "initials": "J"}, {"family": "Martinez-Cruz", "given": "Adan L", "initials": "AL"}], "type": "journal article", "published": "2022-06-07", "journal": {"title": "Urban For Urban Green", "issn": "1618-8667", "issn-l": null, "volume": null, "issue": null, "pages": "127629"}, "abstract": "Urban green spaces' well documented role as a hub for physical and mental health was enhanced by restrictions to mobility issued worldwide as a response to COVID-19. In this context, managers of urban green spaces (UGS) were prompted to provide controlled access under impromptu safety protocols. This unprecedented challenge required planning and operational strengths reflecting flexibility, innovation and learning. These management features are essential for an adaptive governance -an underdeveloped research topic within the study of UGS. Using eighteen semi-structured interviews from six countries, we analyze adaptive governance as reflected by UGS managers' responses across Latin America -a region where access to UGS is a matter of public health and of environmental justice. We document responses that can be categorized based on the governance arrangement in place. On one hand, both polycentric and dedicated-management governances have been able to learn through piloting ideas, adapting personnel roles and the function of UGS infrastructure, and adjusting their decision-making process. On the other hand, managers within municipal public services areas -the most prevalent governance arrangement across Latin America- report difficulty to adapt -likely due to their dependence on political will, lack of continuity due limited autonomy, insufficient budgets, absence of formal paths to self-funding, shortage of technical know-how, and insufficient citizens' involvement. We discuss implications of UGS adaptive governance in terms of capacity to deal with future public health, climate-related or other types of shocks.", "doi": "10.1016/j.ufug.2022.127629", "pmid": "35692898", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S1618-8667(22)00172-8"}, {"db": "pmc", "key": "PMC9173828"}], "notes": [], "created": "2022-06-20T18:19:42.797Z", "modified": "2022-11-09T08:41:42.833Z"}, {"entity": "publication", "iuid": "a01b9a875b2a471eb4148059febe5472", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a01b9a875b2a471eb4148059febe5472.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a01b9a875b2a471eb4148059febe5472"}}, "title": "I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations.", "authors": [{"family": "Files", "given": "Daniel Clark", "initials": "DC", "orcid": "0000-0002-1595-4080", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7921bbd010a24850ba0c57d0e591d5ba.json"}}, {"family": "Matthay", "given": "Michael A", "initials": "MA"}, {"family": "Calfee", "given": "Carolyn S", "initials": "CS"}, {"family": "Aggarwal", "given": "Neil R", "initials": "NR"}, {"family": "Asare", "given": "Adam L", "initials": "AL"}, {"family": "Beitler", "given": "Jeremy R", "initials": "JR"}, {"family": "Berger", "given": "Paul A", "initials": "PA"}, {"family": "Burnham", "given": "Ellen L", "initials": "EL"}, {"family": "Cimino", "given": "George", "initials": "G"}, {"family": "Coleman", "given": "Melissa H", "initials": "MH"}, {"family": "Crippa", "given": "Alessio", "initials": "A"}, {"family": "Discacciati", "given": "Andrea", "initials": "A"}, {"family": "Gandotra", "given": "Sheetal", "initials": "S", "orcid": "0000-0002-5475-9704", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/875d45a15b964498992ab468206dd2fa.json"}}, {"family": "Gibbs", "given": "Kevin W", "initials": "KW"}, {"family": "Henderson", "given": "Paul T", "initials": "PT"}, {"family": "Ittner", "given": "Caroline A G", "initials": "CAG"}, {"family": "Jauregui", "given": "Alejandra", "initials": "A"}, {"family": "Khan", "given": "Kashif T", "initials": "KT"}, {"family": "Koff", "given": "Jonathan L", "initials": "JL"}, {"family": "Lang", "given": "Julie", "initials": "J"}, {"family": "LaRose", "given": "Mary", "initials": "M"}, {"family": "Levitt", "given": "Joe", "initials": "J"}, {"family": "Lu", "given": "Ruixiao", "initials": "R"}, {"family": "McKeehan", "given": "Jeffrey D", "initials": "JD"}, {"family": "Meyer", "given": "Nuala J", "initials": "NJ"}, {"family": "Russell", "given": "Derek W", "initials": "DW", "orcid": "0000-0002-2716-1344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13774f6125b448b1a63423f9f5fa1cab.json"}}, {"family": "Thomas", "given": "Karl W", "initials": "KW"}, {"family": "Eklund", "given": "Martin", "initials": "M"}, {"family": "Esserman", "given": "Laura J", "initials": "LJ"}, {"family": "Liu", "given": "Kathleen D", "initials": "KD"}, {"family": "ISPY COVID Adaptive Platform Trial Network", "given": "", "initials": ""}, {"family": "undefined", "given": "", "initials": ""}], "type": "journal article", "published": "2022-06-06", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "6", "pages": "e060664", "issn-l": "2044-6055"}, "abstract": "The COVID-19 pandemic brought an urgent need to discover novel effective therapeutics for patients hospitalised with severe COVID-19. The Investigation of Serial studies to Predict Your Therapeutic Response with Imaging And moLecular Analysis (ISPY COVID-19 trial) was designed and implemented in early 2020 to evaluate investigational agents rapidly and simultaneously on a phase 2 adaptive platform. This manuscript outlines the design, rationale, implementation and challenges of the ISPY COVID-19 trial during the first phase of trial activity from April 2020 until December 2021.\n\nThe ISPY COVID-19 Trial is a multicentre open-label phase 2 platform trial in the USA designed to evaluate therapeutics that may have a large effect on improving outcomes from severe COVID-19. The ISPY COVID-19 Trial network includes academic and community hospitals with significant geographical diversity across the country. Enrolled patients are randomised to receive one of up to four investigational agents or a control and are evaluated for a family of two primary outcomes-time to recovery and mortality. The statistical design uses a Bayesian model with 'stopping' and 'graduation' criteria designed to efficiently discard ineffective therapies and graduate promising agents for definitive efficacy trials. Each investigational agent arm enrols to a maximum of 125 patients per arm and is compared with concurrent controls. As of December 2021, 11 investigational agent arms had been activated, and 8 arms were complete. Enrolment and adaptation of the trial design are ongoing.\n\nISPY COVID-19 operates under a central institutional review board via Wake Forest School of Medicine IRB00066805. Data generated from this trial will be reported in peer-reviewed medical journals.\n\nNCT04488081.", "doi": "10.1136/bmjopen-2021-060664", "pmid": "35667714", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-060664"}, {"db": "ClinicalTrials.gov", "key": "NCT04488081"}], "notes": [], "created": "2022-06-20T19:34:00.059Z", "modified": "2022-06-20T19:34:14.060Z"}, {"entity": "publication", "iuid": "cac43704a1494c379d09ea40681613e4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cac43704a1494c379d09ea40681613e4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cac43704a1494c379d09ea40681613e4"}}, "title": "Critical care nurses' perception of moral distress in intensive care during the COVID-19 pandemic - A pilot study.", "authors": [{"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Nordin", "given": "Anna", "initials": "A"}, {"family": "Engstr\u00f6m", "given": "\u00c5sa", "initials": "\u00c5"}], "type": "journal article", "published": "2022-06-06", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "pages": "103279", "issn-l": null}, "abstract": "To describe critical care nurses' perception of moral distress during the second year of the COVID-19 pandemic.\n\nA cross-sectional study involving a questionnaire was conducted. Participants responded to the Italian version of the Moral Distress Scale-Revised, which consists of 14 items divided in dimensions Futile care (three items), Ethical misconduct (five items), Deceptive communication (three items) and Poor teamwork (three items). For each item, participants were also invited to write about their experiences and participants' intention to leave a position now was measured by a dichotomous question. The data were analysed with descriptive statistics and qualitative content analysis. The study followed the checklist (CHERRIES) for reporting results of internet surveys.\n\nCritical care nurses (n = 71) working in Swedish adult intensive care units.\n\nCritical care nurses experienced the intensity of moral distress as the highest when no one decided to withdraw ventilator support to a hopelessly ill person (Futile care), and when they had to assist another physician or nurse who provided incompetent care (Poor teamwork). Thirty-nine percent of critical care nurses were considering leaving their current position because of moral distress.\n\nDuring the COVID-19 pandemic, critical care nurses, due to their education and experience of intensive care nursing, assume tremendous responsibility for critically ill patients. Throughout, communication within the intensive care team seems to have a bearing on the degree of moral distress. Improvements in communication and teamwork are needed to reduce moral distress among critical care nurses.", "doi": "10.1016/j.iccn.2022.103279", "pmid": "35688753", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(22)00082-9"}], "notes": [], "created": "2022-06-20T19:25:13.462Z", "modified": "2022-06-20T19:25:25.362Z"}, {"entity": "publication", "iuid": "6ebf9ae4745f4cbf92e3d685d0c1e517", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ebf9ae4745f4cbf92e3d685d0c1e517.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ebf9ae4745f4cbf92e3d685d0c1e517"}}, "title": "Angiopoietin-2 Inhibition of Thrombomodulin-Mediated Anticoagulation-A Novel Mechanism That May Contribute to Hypercoagulation in Critically Ill COVID-19 Patients.", "authors": [{"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Fromell", "given": "Karin", "initials": "K", "orcid": "0000-0001-8905-8791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9342eb4305954aba853bdf3a8153ab67.json"}}, {"family": "Larsson", "given": "Anders", "initials": "A", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2be858ab604743b72383dfdcd14689.json"}}, {"family": "Persson", "given": "Barbro", "initials": "B"}, {"family": "Nilsson", "given": "Bo", "initials": "B"}, {"family": "Quaggin", "given": "Susan E", "initials": "SE"}, {"family": "Betsholtz", "given": "Christer", "initials": "C"}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Jeansson", "given": "Marie", "initials": "M", "orcid": "0000-0003-1075-8563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae2c63715b0f4a5b8127552ab84a1bf3.json"}}], "type": "journal article", "published": "2022-06-06", "journal": {"title": "Biomedicines", "issn": "2227-9059", "issn-l": null, "volume": "10", "issue": "6", "pages": null}, "abstract": "Hypercoagulation and endothelial dysfunction play central roles in severe forms of COVID-19 infections, but the molecular mechanisms involved are unclear. Increased plasma levels of the inflammatory cytokine and TIE2 receptor antagonist Angiopoietin-2 were reported in severely ill COVID-19 patients. In vitro experiments suggest that Angiopoietin-2 bind and inhibits thrombomodulin. Thrombomodulin is expressed on the luminal surface of endothelial cells where it is an important member of the intrinsic anticoagulant pathway through activation of protein C. Using clinical data, mouse models, and in vitro assays, we tested if Angiopoietin-2 plays a causal role in COVID-19-associated hypercoagulation through direct inhibition of thrombin/thrombomodulin-mediated physiological anticoagulation. Angiopoietin-2 was measured in 61 patients at admission, and after 10 days in the 40 patients remaining in the ICU. We found that Angiopoietin-2 levels were increased in COVID-19 patients in correlation with disease severity, hypercoagulation, and mortality. In support of a direct effect of Angiopoietin-2 on coagulation, we found that injected Angiopoietin-2 in mice associated to thrombomodulin and resulted in a shortened tail bleeding time, decreased circulating levels of activated protein C, and increased plasma thrombin/antithrombin complexes. Conversely, bleeding time was increased in endothelial-specific Angiopoietin-2 knockout mice, while knockout of Tie2 had no effect on tail bleeding. Using in vitro assays, we found that Angiopoietin-2 inhibited thrombomodulin-mediated anticoagulation and protein C activation in human donor plasma. Our data suggest a novel in vivo mechanism for Angiopoietin-2 in COVID-19-associated hypercoagulation, implicating that Angiopoietin-2 inhibitors may be effective in the treatment of hypercoagulation in severe COVID-19 infection.", "doi": "10.3390/biomedicines10061333", "pmid": "35740360", "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "biomedicines10061333"}, {"db": "pmc", "key": "PMC9220312"}, {"db": "URL", "key": "https://doi.org/10.17044/scilifelab.14229410", "description": "https://doi.org/10.17044/scilifelab.14229410"}], "notes": [], "created": "2022-08-19T05:49:08.807Z", "modified": "2022-08-19T12:36:44.560Z"}, {"entity": "publication", "iuid": "8a0ac9252cfb436fbe1fe3f923db30de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a0ac9252cfb436fbe1fe3f923db30de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a0ac9252cfb436fbe1fe3f923db30de"}}, "title": "Hospital bed occupancy for COVID-19 or with SARS-CoV-2 infection in a Swedish county during the omicron wave.", "authors": [{"family": "Spreco", "given": "Armin", "initials": "A"}, {"family": "Andersson", "given": "Christer", "initials": "C"}, {"family": "Sj\u00f6dahl", "given": "Rune", "initials": "R"}, {"family": "Dahlstr\u00f6m", "given": "\u00d6rjan", "initials": "\u00d6"}, {"family": "Timpka", "given": "Toomas", "initials": "T", "orcid": "0000-0001-6049-5402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebcb4fac20f845a4bd9eaa4bf1660ebb.json"}}], "type": "letter", "published": "2022-06-05", "journal": {"title": "Influenza Other Respir Viruses", "issn": "1750-2659", "issn-l": null}, "abstract": null, "doi": "10.1111/irv.13019", "pmid": "35666005", "labels": {"Category: Omicron VoC": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-20T19:34:35.273Z", "modified": "2022-06-20T19:34:35.310Z"}, {"entity": "publication", "iuid": "97e8169c1e9d46fc836abc9d4315fbd7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/97e8169c1e9d46fc836abc9d4315fbd7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/97e8169c1e9d46fc836abc9d4315fbd7"}}, "title": "Organizational logics in time of crises: How physicians narrate the healthcare response to the Covid-19 pandemic in Swedish hospitals.", "authors": [{"family": "Jacobsson", "given": "Maritha", "initials": "M"}, {"family": "H\u00e4rgestam", "given": "Maria", "initials": "M"}, {"family": "B\u00e5\u00e5the", "given": "Fredrik", "initials": "F"}, {"family": "Hagqvist", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2022-06-03", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "volume": "22", "issue": "1", "pages": "738", "issn-l": null}, "abstract": "The COVID-19 pandemic has challenged healthcare organizations and puts focus on risk management in many ways. Both medical staff and leaders at various levels have been forced to find solutions to problems they had not previously encountered. This study aimed to explore how physicians in Sweden narrated the changes in organizational logic in response to the Covid-19 pandemic using neo-institutional theory and discursive psychology. In specific, we aimed to explore how physicians articulated their understanding of if and, in that case, how the organizational logic has changed during this crisis response.\n\nThe empirical material stems from interviews with 29 physicians in Sweden in the summer and autumn of 2020. They were asked to reflect on the organizational response to the pandemic focusing on leadership, support, working conditions, and patient care.\n\nThe analysis revealed that the organizational logic in Swedish healthcare changed and that the physicians came in troubled positions as leaders. With management, workload, and risk repertoires, the physicians expressed that the organizational logic, to a large extent, was changed based on local contextual circumstances in the 21 self-governing regions. The organizational logic was being altered based upon how the two powerbases (physicians and managers) were interacting over time.\n\nGiven that healthcare probably will deal with future unforeseen crises, it seems essential that healthcare leaders discuss what can be a sustainable organizational logic. There should be more explicit regulatory elements about who is responsible for what in similar situations. The normative elements have probably been stretched during the ongoing crisis, given that physicians have gained practical experience and that there is now also, at least some evidence-based knowledge about this particular pandemic. But the question is what knowledge they need in their education when it comes to dealing with new unknown risks.", "doi": "10.1186/s12913-022-08094-z", "pmid": "35659289", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-022-08094-z"}], "notes": [], "created": "2022-06-21T17:18:03.286Z", "modified": "2022-06-21T17:18:03.302Z"}, {"entity": "publication", "iuid": "cffb2f3684df41d4a4afe77d5311fc77", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cffb2f3684df41d4a4afe77d5311fc77.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cffb2f3684df41d4a4afe77d5311fc77"}}, "title": "Epidemic risk perceptions in Italy and Sweden driven by authority responses to COVID-19.", "authors": [{"family": "Raffetti", "given": "Elena", "initials": "E"}, {"family": "Mondino", "given": "Elena", "initials": "E"}, {"family": "Di Baldassarre", "given": "Giuliano", "initials": "G"}], "type": "journal article", "published": "2022-06-03", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "9291", "issn-l": "2045-2322"}, "abstract": "Understanding public risk perception is an essential step to develop effective measures reducing the spread of disease outbreaks. Here we compare epidemic risk perceptions during two different periods of the COVID-19 pandemic in Italy and Sweden. To this end, we analyzed the results of two nationwide surveys carried out in both countries in two periods characterized by different infection rates: August (N = 4154) and November 2020 (N = 4168). Seven domains of epidemic risk perception were considered: likelihood along with (individual and population) impact, preparedness, and knowledge. The role of the context and period was explored in stratified and formal interaction analyses. In both countries, we found an intensification in epidemic risk perception from August to November 2020. Being male, older and having a higher relative income were associated with a lower perception of the likelihood of epidemics, while excess mortality was marginally related to higher odds. Compared to Sweden, Italy had a higher increase in perception of likelihood and impact, and a concurrent decrease in preparedness and knowledge. The different authority response to the COVID-19 pandemic is associated with a different change over time in risk perception. Regional differences in terms of excess mortality only marginally explained differences in risk perception.", "doi": "10.1038/s41598-022-13218-w", "pmid": "35662262", "labels": {"Type: Journal article": null, "Category: Health": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC9164564"}, {"db": "pii", "key": "10.1038/s41598-022-13218-w"}], "notes": [], "created": "2022-06-20T19:35:33.529Z", "modified": "2023-01-13T14:43:02.040Z"}, {"entity": "publication", "iuid": "0dd07c255c91411ca3447617601e604c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0dd07c255c91411ca3447617601e604c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0dd07c255c91411ca3447617601e604c"}}, "title": "Burden of Disease of COVID-19: Strengthening the Collaboration for National Studies.", "authors": [{"family": "Pires", "given": "Sara Monteiro", "initials": "SM"}, {"family": "Wyper", "given": "Grant M A", "initials": "GMA"}, {"family": "Wengler", "given": "Annelene", "initials": "A"}, {"family": "Pe\u00f1alvo", "given": "Jos\u00e9 L", "initials": "JL"}, {"family": "Haneef", "given": "Romana", "initials": "R"}, {"family": "Moran", "given": "Declan", "initials": "D"}, {"family": "Cuschieri", "given": "Sarah", "initials": "S"}, {"family": "Redondo", "given": "Hernan G", "initials": "HG"}, {"family": "De Pauw", "given": "Robby", "initials": "R"}, {"family": "McDonald", "given": "Scott A", "initials": "SA"}, {"family": "Moon", "given": "Lynelle", "initials": "L"}, {"family": "Shedrawy", "given": "Jad", "initials": "J"}, {"family": "Pallari", "given": "Elena", "initials": "E"}, {"family": "Charalampous", "given": "Periklis", "initials": "P"}, {"family": "Devleesschauwer", "given": "Brecht", "initials": "B"}, {"family": "Von Der Lippe", "given": "Elena", "initials": "E"}], "type": "journal article", "published": "2022-06-03", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "10", "pages": "907012", "issn-l": "2296-2565"}, "abstract": "Quantifying the combined impact of morbidity and mortality is a key enabler to assessing the impact of COVID-19 across countries and within countries relative to other diseases, regions, or demographics. Differences in methods, data sources, and definitions of mortality due to COVID-19 may hamper comparisons. We describe efforts to support countries in estimating the national-level burden of COVID-19 using disability-adjusted life years.\n\nThe European Burden of Disease Network developed a consensus methodology, as well as a range of capacity-building activities to support burden of COVID-19 studies. These activities have supported 11 national studies so far, with study periods between January 2020 and December 2021.\n\nNational studies dealt with various data gaps and different assumptions were made to face knowledge gaps. Still, they delivered broadly comparable results that allow for interpretation of consistencies, as well as differences in the quantified direct health impact of the pandemic.\n\nHarmonized efforts and methodologies have allowed for comparable estimates and communication of results. Future studies should evaluate the impact of interventions, and unravel the indirect health impact of the COVID-19 crisis.", "doi": "10.3389/fpubh.2022.907012", "pmid": "35734754", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC9208200"}], "notes": [], "created": "2022-08-19T05:52:02.531Z", "modified": "2022-08-19T05:52:02.544Z"}, {"entity": "publication", "iuid": "6b3231f157f94108849d7d57fd82e8a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b3231f157f94108849d7d57fd82e8a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b3231f157f94108849d7d57fd82e8a4"}}, "title": "The Karolinska KI/K COVID-19 Immune Atlas: An open resource for immunological research and educational purposes.", "authors": [{"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Ask", "given": "Eivind Heggernes", "initials": "EH", "orcid": "0000-0001-8655-1433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad160fa96dd94738a713f5c6934e61fa.json"}}, {"family": "Cornillet", "given": "Martin", "initials": "M"}, {"family": "Strunz", "given": "Benedikt", "initials": "B"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Rao Muvva", "given": "Jagadeeswara", "initials": "J"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Chambers", "given": "Benedict J", "initials": "BJ", "orcid": "0000-0003-0437-8441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6089d99ec42d475f8f57c8d8cc1ff1de.json"}}, {"family": "Cuapio", "given": "Angelica", "initials": "A", "orcid": "0000-0002-9451-1914", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f4915fdfa7d460f9b705b56b0fc1c4a.json"}}, {"family": "Dzidic", "given": "Majda", "initials": "M"}, {"family": "Filipovic", "given": "Iva", "initials": "I", "orcid": "0000-0002-8166-5500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c79974df90ae4fbf8be348b9b47d0317.json"}}, {"family": "Flodstr\u00f6m-Tullberg", "given": "Malin", "initials": "M"}, {"family": "Garcia", "given": "Marina", "initials": "M"}, {"family": "Gorin", "given": "Jean-Baptiste", "initials": "J"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Hertwig", "given": "Laura", "initials": "L"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Kokkinou", "given": "Efthymia", "initials": "E"}, {"family": "Kvedaraite", "given": "Egle", "initials": "E"}, {"family": "Lourda", "given": "Magda", "initials": "M"}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J"}, {"family": "Maucourant", "given": "Christopher", "initials": "C"}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A"}, {"family": "Palma Medina", "given": "Laura M", "initials": "LM"}, {"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Perez-Potti", "given": "Andr\u00e9", "initials": "A"}, {"family": "Ponzetta", "given": "Andrea", "initials": "A"}, {"family": "Ringqvist", "given": "Emma", "initials": "E"}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Sandberg", "given": "J Tyler", "initials": "JT"}, {"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "Svensson", "given": "Mattias", "initials": "M", "orcid": "0000-0003-1695-7934", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7ae76a597164d02b4fcfadfe53c48a3.json"}}, {"family": "Varnaite", "given": "Renata", "initials": "R"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Karolinska KI/K COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Malmberg", "given": "Karl-Johan", "initials": "K"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}], "type": "journal article", "published": "2022-06-02", "journal": {"title": "Scand J Immunol", "issn": "1365-3083", "issn-l": null, "volume": null, "issue": null, "pages": "e13195"}, "abstract": "The Karolinska KI/K COVID-19 Immune Atlas project was conceptualized in March 2020 as a part of the academic research response to the developing SARS-CoV-2 pandemic. The aim was to rapidly provide a curated dataset covering the acute immune response towards SARS-CoV-2 infection in humans, as it occurred during the first wave. The Immune Atlas was built as an open resource for broad research and educational purposes. It contains a presentation of the response evoked by different immune and inflammatory cells in defined na\u00efve patient-groups as they presented with moderate and severe COVID-19 disease. The present Resource Article describes how the Karolinska KI/K COVID-19 Immune Atlas allow scientists, students, and other interested parties to freely explore the nature of the immune response towards human SARS-CoV-2 infection in an online setting.", "doi": "10.1111/sji.13195", "pmid": "35652743", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Category: Other": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "URL", "key": "http://www.covid19cellatlas.com/", "description": "http://www.covid19cellatlas.com/"}], "notes": [], "created": "2022-06-21T17:25:20.401Z", "modified": "2022-06-21T17:31:07.574Z"}, {"entity": "publication", "iuid": "b0c9b466e4b145bb9cc631e82cf6011c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b0c9b466e4b145bb9cc631e82cf6011c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b0c9b466e4b145bb9cc631e82cf6011c"}}, "title": "The International Academy of Health Sciences Informatics: 2021 Update.", "authors": [{"family": "Hersh", "given": "William R", "initials": "WR"}, {"family": "Haux", "given": "Reinhold", "initials": "R"}, {"family": "Huesing", "given": "Elaine", "initials": "E"}, {"family": "Ball", "given": "Marion J", "initials": "MJ"}, {"family": "Kimura", "given": "Michio", "initials": "M"}, {"family": "Otero", "given": "Paula", "initials": "P"}, {"family": "Detmer", "given": "Don", "initials": "D"}, {"family": "Koch", "given": "Sabine", "initials": "S"}, {"family": "Saranto", "given": "Kaija K", "initials": "KK"}, {"family": "Wright", "given": "Graham", "initials": "G"}], "type": "journal article", "published": "2022-06-02", "journal": {"title": "Yearb Med Inform", "issn": "2364-0502", "issn-l": null}, "abstract": "To summarize the activities of the International Academy of Health Sciences Informatics (IAHSI) in 2021 and welcome its 2021 Class of Fellows.\n\nReport on governance, strategic directions, newly elected fellows, plenary meetings, and other activities of the Academy.\n\nAs in 2020, all of the Academy's activities were carried out virtually due to the COVID-19 pandemic. In 2021, new Board members were elected. Strategic activities in data standards and interoperability and in mentorship moved forward. A new class of 26 Fellows was elected, bringing the total membership of the Academy to 204 Fellows from all regions of the world. In addition, a virtual plenary meeting was held.\n\nThe Academy has continued to pursue its role as the honorific society globally for biomedical and health informatics. Expansion of strategic activities and membership will continue moving forward.", "doi": "10.1055/s-0042-1742501", "pmid": "35654427", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T17:20:41.316Z", "modified": "2022-06-21T17:20:41.329Z"}, {"entity": "publication", "iuid": "b8b02774a6a744df875d0f9e1a91c944", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8b02774a6a744df875d0f9e1a91c944.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8b02774a6a744df875d0f9e1a91c944"}}, "title": "No learning loss in Sweden during the pandemic evidence from primary school reading assessments.", "authors": [{"family": "Hallin", "given": "Anna Eva", "initials": "AE"}, {"family": "Danielsson", "given": "Henrik", "initials": "H"}, {"family": "Nordstr\u00f6m", "given": "Thomas", "initials": "T"}, {"family": "F\u00e4lth", "given": "Linda", "initials": "L"}], "type": "journal article", "published": "2022-06-02", "journal": {"title": "Int J Educ Res", "issn": "0883-0355", "issn-l": null, "volume": "114", "issue": null, "pages": "102011"}, "abstract": "The COVID-19 pandemic has led to worldwide school closures, with a risk of learning loss. Sweden kept primary schools open, but it is unknown whether student and teacher absence and pandemic-related stress factors affected teaching and student progress negatively. In this study, reading assessment data from 97,073 Swedish primary school students (grades 1-3) were analysed to investigate potential learning loss. Results showed that word decoding and reading comprehension scores were not lower during the pandemic compared to before the pandemic, that students from low socio-economic backgrounds were not especially affected, and that the proportion of students with weak decoding skills did not increase during the pandemic. Study limitations are discussed. We conclude that open schools benefitted Swedish primary school students.", "doi": "10.1016/j.ijer.2022.102011", "pmid": "35677729", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0883-0355(22)00089-1"}, {"db": "pmc", "key": "PMC9162440"}], "notes": [], "created": "2022-06-20T19:31:04.068Z", "modified": "2022-11-09T08:42:18.260Z"}, {"entity": "publication", "iuid": "8ecf67a8c27045238eed362c6919a052", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ecf67a8c27045238eed362c6919a052.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ecf67a8c27045238eed362c6919a052"}}, "title": "Integration of systematic screening for tuberculosis in outpatient departments of urban primary healthcare facilities in Zambia: a case study of Kitwe district.", "authors": [{"family": "Zulu", "given": "Davy Wadula", "initials": "DW"}, {"family": "Silumbwe", "given": "Adam", "initials": "A"}, {"family": "Maritim", "given": "Patricia", "initials": "P"}, {"family": "Zulu", "given": "Joseph Mumba", "initials": "JM"}], "type": "journal article", "published": "2022-06-02", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "volume": "22", "issue": "1", "pages": "732", "issn-l": null}, "abstract": "Tuberculosis (TB) is the leading cause of death from a single infectious agent globally, killing about 1.5 million people annually, yet 3 million cases are missed every year. The World Health Organization recommends systematic screening of suspected active TB patients among those visiting the healthcare facilities. While many countries have scaled-up systematic screening of TB, there has been limited assessment of the extent of its integration into the health system. This study sought to explore factors that shape the integration of systematic screening of TB in outpatient departments of primary healthcare facilities in Kitwe district, Zambia.\n\nThis was a qualitative case study with health providers including district managers, TB focal point persons and laboratory personnel working in six purposively selected primary healthcare facilities. Data was collected through key informant (n = 8) and in-depth (n = 15) interviews. Data analysis was conducted using QDA Miner software and guided by Atun's Integration framework.\n\nThe facilitators to integration of systematic screening for TB into out patient departments of primary health facilities included the perceived high burden TB, compatibility of the systematic screening for TB program with healthcare workers training and working schedules, stakeholder knowledge of each others interest and values, regular performance management and integrated outreach of TB screening services. Constraining factors to integration of systematic screening for TB into outpatient departments included complexity of screening for TB in children, unbalanced incentivization mechanisms, ownership and legitimacy of the TB screening program, negative health worker attitudes, social cultural misconceptions of TB and societal stigma as well as the COVID-19 pandemic.\n\nSystematic screening of TB is not fully integrated into the primary healthcare facilities in Zambia to capture all those suspected with active TB that make contact with the health system. Finding the missing TB cases will, therefore, require contextual adaptation of the systematic screening for TB program to local needs and capacities as well as strengthening the health system.", "doi": "10.1186/s12913-022-08043-w", "pmid": "35655301", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-022-08043-w"}], "notes": [], "created": "2022-06-21T17:20:22.124Z", "modified": "2022-06-21T17:20:22.136Z"}, {"entity": "publication", "iuid": "6cca6c1a8846428ba8ad2030031ab08e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6cca6c1a8846428ba8ad2030031ab08e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6cca6c1a8846428ba8ad2030031ab08e"}}, "title": "Changes in Brain-Health Related Modifiable Risk Factors in Older Adults After One Year of COVID-19-Restrictions.", "authors": [{"family": "Waterink", "given": "Lisa", "initials": "L"}, {"family": "Bakker", "given": "Els D", "initials": "ED"}, {"family": "Visser", "given": "Leonie N C", "initials": "LNC"}, {"family": "Mangialasche", "given": "Francesca", "initials": "F"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Deckers", "given": "Kay", "initials": "K"}, {"family": "K\u00f6hler", "given": "Sebastian", "initials": "S"}, {"family": "Sikkes", "given": "Sietske A M", "initials": "SAM"}, {"family": "Prins", "given": "Niels D", "initials": "ND"}, {"family": "Scheltens", "given": "Philip", "initials": "P"}, {"family": "van der Flier", "given": "Wiesje M", "initials": "WM"}, {"family": "Zwan", "given": "Marissa D", "initials": "MD"}], "type": "journal article", "published": "2022-06-02", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "13", "pages": "877460", "issn-l": "1664-0640"}, "abstract": "The COVID-19 pandemic has major influence on lifestyle and mental health, which might affect brain-health and increase the risk of cognitive decline, particularly in older adults. We aimed to describe changes in modifiable risk factors related to brain-health in older adults after one year of COVID-19 restrictions.\n\nAn online survey was disseminated between February and March 2021 to 17,773 registrants of the Dutch Brain Research Registry, aged \u226550, without a self-reported diagnosis of mild cognitive impairment or dementia. Participants were asked to report potential changes in behaviors during the COVID-19 pandemic, compared to pre-pandemic, in eight domains related to brain health: physical activity, sleep, feeling of memory decline, perceived stress, feeling of loneliness, diet, alcohol consumption, and smoking. We used negative binomial regression analyses to relate (socio)demographics, subjective memory complaints and COVID-19 related aspects (fear of, or current/past COVID-19 infection) to the number of reported detrimental and beneficial changes as dependent variable.\n\n3,943 participants (66 \u00b1 8 years old; 76% female; 71% highly educated) completed the survey. After one year of COVID-19-restrictions, 74% reported at least one detrimental lifestyle change unfavorable for their brain health, most frequently reported were feelings of loneliness, sleep problems, and less physical activity. 60% of participants reported at least one beneficial change, which were most often more physical activity, healthier dietary habits, and less alcohol consumption. Individuals who are younger [incidence rate ratio (IRR) = 0.99, 95% CI = 0.98-0.99], female (1.20, 1.11-1.30), living alone (1.20, 1.11-1.28) and in urban environments (1.18, 1.08-1.29), who are less satisfied with their income (1.38, 1.17-1.62), experiencing subjective memory complaints (1.40, 1.28-1.52) and those with a past or current (1.19, 1.06-1.34) or fear of a COVID-19 infection (1.33, 1.25-1.42) reported higher numbers of detrimental changes.\n\nThe COVID-19 pandemic has influenced lifestyle in both positive and negative ways. We identified (socio)demographic factors associated with more detrimental changes in modifiable risk factors related to brain health, suggesting that some individuals are more vulnerable for the impact of the COVID-19 pandemic. These findings provide an opportunity for targeted prevention and education to promote a healthy lifestyle during and after the pandemic.", "doi": "10.3389/fpsyt.2022.877460", "pmid": "35722572", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9201112"}], "notes": [], "created": "2022-06-20T18:04:12.788Z", "modified": "2022-08-17T12:45:33.702Z"}, {"entity": "publication", "iuid": "9cd5cf69381f4d3196ee195a00a48d84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9cd5cf69381f4d3196ee195a00a48d84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9cd5cf69381f4d3196ee195a00a48d84"}}, "title": "A Network Analysis of the Fear of COVID-19 Scale (FCV-19S): A Large-Scale Cross-Cultural Study in Iran, Bangladesh, and Norway.", "authors": [{"family": "Lecuona", "given": "Oscar", "initials": "O", "orcid": "0000-0003-0080-1062", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3c84f17b7bf4210aa39eeb252d8bd33.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Rozgonjuk", "given": "Dmitri", "initials": "D"}, {"family": "Norekv\u00e5l", "given": "Tone M", "initials": "TM"}, {"family": "Iversen", "given": "Marjolein M", "initials": "MM"}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA", "orcid": "0000-0002-1728-8966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6e65a5a97154d159a63cc2ce3f1b7a8.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Lin", "given": "Ting-I", "initials": "TI"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2022-06-02", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "11", "issn-l": null}, "abstract": "The rapid spread of the coronavirus disease 2019 (COVID-19) has led to high levels of fear worldwide. Given that fear is an important factor in causing psychological distress and facilitating preventive behaviors, assessing the fear of COVID-19 is important. The seven-item Fear of COVID-19 Scale (FCV-19S) is a widely used psychometric instrument to assess this fear. However, the factor structure of the FCV-19S remains unclear according to the current evidence. Therefore, the present study used a network analysis to provide further empirical evidence for the factor structure of FCV-19S. A total of 24,429 participants from Iran (n = 10,843), Bangladesh (n = 9906), and Norway (n = 3680) completed the FCV-19S in their local language. A network analysis (via regularized partial correlation networks) was applied to investigate the seven FCV-19S items. Moreover, relationships between the FCV-19S items were compared across gender (males vs. females), age groups (18-30 years, 31-50 years, and &gt;50 years), and countries (Iran, Bangladesh, and Norway). A two-factor structure pattern was observed (three items concerning physical factors, including clammy hands, insomnia, and heart palpitations; four items concerning psychosocial factors, including being afraid, uncomfortable, afraid of dying, and anxious about COVID-19 news). Moreover, this pattern was found to be the same among men and women, across age groups and countries. The network analysis used in the present study verified the two-factor structure for the FCV-19S. Future studies may consider using the two-factor structure of FCV-19S to assess the fear of COVID-19 during the COVID-19 era.", "doi": "10.3390/ijerph19116824", "pmid": "35682405", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19116824"}], "notes": [], "created": "2022-06-20T19:27:26.888Z", "modified": "2022-06-20T19:27:26.996Z"}, {"entity": "publication", "iuid": "f479e90cff3441c792c233351414db88", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f479e90cff3441c792c233351414db88.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f479e90cff3441c792c233351414db88"}}, "title": "Remote investigation and assessment of vital signs (RIA-VS)-proof of concept for contactless estimation of blood pressure, pulse, respiratory rate, and oxygen saturation in patients with suspicion of COVID-19.", "authors": [{"family": "Malmberg", "given": "Stefan", "initials": "S"}, {"family": "Khan", "given": "Taha", "initials": "T"}, {"family": "Gunnarsson", "given": "Ronny", "initials": "R", "orcid": "0000-0001-9183-3072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f25154a31c304d23bb9d37ec121eedd2.json"}}, {"family": "Jacobsson", "given": "Gunnar", "initials": "G"}, {"family": "Sundvall", "given": "P\u00e4r-Daniel", "initials": "PD"}], "type": "journal article", "published": "2022-06-01", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "pages": "1-10", "issn-l": "2374-4235"}, "abstract": "Vital signs are critical in assessing the severity and prognosis of infections, for example, COVID-19, influenza, sepsis, and pneumonia. This study aimed to evaluate a new method for rapid camera-based non-contact measurement of heart rate, blood oxygen saturation, respiratory rate, and blood pressure.\n\nConsecutive adult patients attending a hospital emergency department for suspected COVID-19 infection were invited to participate. Vital signs measured with a new camera-based method were compared to the corresponding standard reference methods. The camera device observed the patient's face for 30 s from \u223c1 m.\n\nBetween 1 April and 1 October 2020, 214 subjects were included in the trial, 131 female (61%) and 83 male (39%). The mean age was 44 years (range 18-81 years). The new camera-based device's vital signs measurements were, on average, very close to the gold standard but the random variation was larger than the reference methods.\n\nThe principle of contactless measurement of blood pressure, pulse, respiratory rate, and oxygen saturation works, which is very promising. However, technical improvements to the equipment used in this study to reduce its random variability is required before clinical implementation. This will likely be a game changer once this is sorted out.\n\nUniversal Trial Number (UTN) U1111-1251-4114 and the ClinicalTrials.gov Identifier NCT04383457.", "doi": "10.1080/23744235.2022.2080249", "pmid": "35651319", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT04383457"}], "notes": [], "created": "2022-06-21T17:31:18.532Z", "modified": "2022-06-21T17:31:18.615Z"}, {"entity": "publication", "iuid": "b69f6910420f46ae80cc4a4072f8d2c4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b69f6910420f46ae80cc4a4072f8d2c4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b69f6910420f46ae80cc4a4072f8d2c4"}}, "title": "Missed nursing care in the critical care unit, before and during the COVID-19 pandemic: A comparative cross-sectional study.", "authors": [{"family": "Falk", "given": "Ann-Charlotte", "initials": "AC"}, {"family": "Nymark", "given": "Carolin", "initials": "C"}, {"family": "G\u00f6ransson", "given": "Katarina E", "initials": "KE"}, {"family": "von Vogelsang", "given": "Ann-Christin", "initials": "AC"}], "type": "journal article", "published": "2022-06-01", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "pages": "103276", "issn-l": null}, "abstract": "Todescribe and evaluate reported missed nursing care in the critical care context during different phases of the COVID-19 pandemic in Sweden.\n\nA comparative cross-sectional design was used, comparing missed nursing care in three samples: before the COVID-19 pandemic in 2019, during the second wave of the pandemic in spring 2020, and during the third wave of the pandemic in fall 2021.\n\nThe study was conducted at critical care units at a university hospital, Sweden.\n\nThe MISSCARE Survey-Swedish version was used to collect data along with two study-specific questions concerning perception of patient safety and quality of care.\n\nSignificantly more overtime hours and number of days absent due to illness were reported during the pandemic. The nurse/patient ratio was above the recommended level at all data collection time points. Most missed nursing care was reported in items concerning basic care. The most reported reasons for missed nursing care in all samples concerned inadequate staffing, urgent situations, and a rise in patient volume. Most nurses in all samples perceived the level of patient safety and quality of care as good, and the majority had no intention to leave their current position.\n\nThe pandemic had a great impact on the critical care workforce but few elements of missed nursing care were affected. To measure and use missed nursing care as a quality indicator could be valuable for nursing managers, to inform them and improve their ability to meet changes in patient needs with different workforce approaches in critical care settings.", "doi": "10.1016/j.iccn.2022.103276", "pmid": "35672210", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(22)00079-9"}], "notes": [], "created": "2022-06-20T19:31:47.138Z", "modified": "2022-06-20T19:31:56.430Z"}, {"entity": "publication", "iuid": "d6bb41724d964351a7463e2ac105f5f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d6bb41724d964351a7463e2ac105f5f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d6bb41724d964351a7463e2ac105f5f7"}}, "title": "Discovery of a Novel Coronavirus in Swedish Bank Voles (Myodes glareolus).", "authors": [{"family": "Wasberg", "given": "Anishia", "initials": "A"}, {"family": "Raghwani", "given": "Jayna", "initials": "J"}, {"family": "Li", "given": "Jinlin", "initials": "J"}, {"family": "Pettersson", "given": "John H-O", "initials": "JH"}, {"family": "Lindahl", "given": "Johanna F", "initials": "JF"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}], "type": "journal article", "published": "2022-06-01", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "6", "issn-l": "1999-4915"}, "abstract": "The unprecedented pandemic COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with bats as original reservoirs, has once again highlighted the importance of exploring the interface of wildlife diseases and human health. In this study, we identified a novel Betacoronavirus from bank voles (Myodes glareolus) in Grims\u00f6, Sweden, and this virus is designated as Grimso virus. Repeated detection over three years and an overall prevalence of 3.4% suggest that the virus commonly occurs in bank voles. Furthermore, phylogenetic analyses indicate that the Grimso virus belongs to a highly divergent Embecovirus lineage predominantly associated with bank voles. Given that bank voles are one of the most common rodent species in Sweden and Europe, our findings indicate that Grimso virus might be circulating widely in bank voles and further point out the importance of sentinel surveillance of coronaviruses in wild small mammalian animals, especially in wild rodents.", "doi": "10.3390/v14061205", "pmid": "35746677", "labels": {"Category: Biochemistry": null, "Research Area: Pandemic preparedness": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "v14061205"}, {"db": "pmc", "key": "PMC9230040"}], "notes": [], "created": "2022-08-19T05:41:46.521Z", "modified": "2022-08-19T05:43:22.484Z"}, {"entity": "publication", "iuid": "0ff90e6d55554880898f48eeadecda4f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ff90e6d55554880898f48eeadecda4f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ff90e6d55554880898f48eeadecda4f"}}, "title": "COVID-19 vaccines coverage and effectiveness against SARS-CoV-2 infection among residents in the largest Health Authority of Lazio region (Italy): a population-based cohort study.", "authors": [{"family": "Fano", "given": "Valeria", "initials": "V", "orcid": "0000-0003-1396-4928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39fbb5a6eee549c9b1cc336f36e8715c.json"}}, {"family": "Coviello", "given": "Enzo", "initials": "E", "orcid": "0000-0002-8396-2306", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c990efa224a4fc58ef9c318cbfe9541.json"}}, {"family": "Consonni", "given": "Dario", "initials": "D", "orcid": "0000-0002-8935-3843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f533ba417cb4950b77f0b4be5ad8f97.json"}}, {"family": "Agresta", "given": "Alessandro", "initials": "A", "orcid": "0000-0001-8890-0342", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/516cab6c029742b4a037b0f3478df969.json"}}, {"family": "Orsini", "given": "Nicola", "initials": "N", "orcid": "0000-0002-2210-5634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6161818f1f74a26883d3b1e37e72f2e.json"}}, {"family": "Crielesi", "given": "Alessia", "initials": "A"}, {"family": "Miglietta", "given": "Antonio Salvatore", "initials": "AS"}, {"family": "Pasqua", "given": "Caterina", "initials": "C"}, {"family": "Vairo", "given": "Francesco", "initials": "F", "orcid": "0000-0002-8375-7468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d99df4cf90cf43df92915c18d8b97e06.json"}}, {"family": "Vivaldi", "given": "Fabio", "initials": "F"}, {"family": "De Angelis", "given": "Giuseppe", "initials": "G"}, {"family": "Colaiocco", "given": "Giovanni", "initials": "G"}, {"family": "Fabiani", "given": "Massimo", "initials": "M", "orcid": "0000-0002-5893-7117", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6edd0048b0204f43972a2cb3dc08518d.json"}}], "type": "journal article", "published": "2022-06-01", "journal": {"title": "Expert Rev Vaccines", "issn": "1744-8395", "pages": "1-11", "issn-l": null}, "abstract": "The waning of the protective effect of COVID-19 vaccines and timing of booster doses are debated.\n\nPopulation-based cohort study in the largest Health-Authority of Lazio region, Italy, on 946,156 residents aged 12+ (study period: 1 January 2021-10 January 2022). Vaccine effectiveness (VE) against any SARS-CoV-2 infection (symptomatic or asymptomatic) was estimated through multivariable negative-binomial models using unvaccinated person-time as a reference.\n\nThe primary vaccination cycle was completed by 81% of residents; of these, 45% received a booster dose. Vaccine coverages were lower for foreigners, and people living in deprived areas, families with children aged 0-11, and households size 1 or 6+. Overall, VE waned from 71% (95% Confidence Interval (CI) 70-73%) 1 month after the second dose to 43% (CI 41-45%) after 4 months and 24% (CI 21-27%) after 6 months, especially in the elderly aged 70+. We observed a prompt restore of VE 15-19 days after the booster dose (69%, CI 67-70%).\n\nOur results support the recommendation of a booster dose 4 months after completion of the primary cycle, giving priority to elderly and fragile individuals. The lower vaccine coverage among social disadvantaged subgroups suggests the need of targeted communication and interventions.", "doi": "10.1080/14760584.2022.2080057", "pmid": "35584901", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T18:02:42.371Z", "modified": "2022-06-21T18:02:58.354Z"}, {"entity": "publication", "iuid": "28ed47e1513143fea34a4e0061bcd804", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/28ed47e1513143fea34a4e0061bcd804.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/28ed47e1513143fea34a4e0061bcd804"}}, "title": "Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double-blind, randomised, controlled, phase 3 trial.", "authors": [{"family": "Upton", "given": "Caryn M", "initials": "CM"}, {"family": "van Wijk", "given": "Rob C", "initials": "RC"}, {"family": "Mockeliunas", "given": "Laurynas", "initials": "L"}, {"family": "Simonsson", "given": "Ulrika S H", "initials": "USH"}, {"family": "McHarry", "given": "Kirsten", "initials": "K"}, {"family": "van den Hoogen", "given": "Gerben", "initials": "G"}, {"family": "Muller", "given": "Chantal", "initials": "C"}, {"family": "von Delft", "given": "Arn\u00e9", "initials": "A"}, {"family": "van der Westhuizen", "given": "Helene-Mari", "initials": "HM"}, {"family": "van Crevel", "given": "Reinout", "initials": "R"}, {"family": "Walzl", "given": "Gerhard", "initials": "G"}, {"family": "Baptista", "given": "Pedro M", "initials": "PM"}, {"family": "Peter", "given": "Jonathan", "initials": "J"}, {"family": "Diacon", "given": "Andreas H", "initials": "AH"}, {"family": "BCG CORONA Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": "48", "pages": "101414", "issn-l": null}, "abstract": "BCG vaccination prevents severe childhood tuberculosis (TB) and was introduced in South Africa in the 1950s. It is hypothesised that BCG trains the innate immune system by inducing epigenetic and functional reprogramming, thus providing non-specific protection from respiratory tract infections. We evaluated BCG for reduction of morbidity and mortality due to COVID-19 in healthcare workers in South Africa.\n\nThis randomised, double-blind, placebo-controlled trial recruited healthcare workers at three facilities in the Western Cape, South Africa, unless unwell, pregnant, breastfeeding, immunocompromised, hypersensitivity to BCG, or undergoing experimental COVID-19 treatment. Participants received BCG or saline intradermally (1:1) and were contacted once every 4 weeks for 1 year. COVID-19 testing was guided by symptoms. Hospitalisation, COVID-19, and respiratory tract infections were assessed with Cox proportional hazard modelling and time-to-event analyses, and event severity with post hoc Markovian analysis. This study is registered with ClinicalTrials.gov, NCT04379336.\n\nBetween May 4 and Oct 23, 2020, we enrolled 1000 healthcare workers with a median age of 39 years (IQR 30-49), 70\u00b74% were female, 16\u00b75% nurses, 14\u00b74% medical doctors, 48\u00b75% had latent TB, and 15\u00b73% had evidence of prior SARS-CoV-2 exposure. Hospitalisation due to COVID-19 occurred in 15 participants (1\u00b75%); ten (66\u00b77%) in the BCG group and five (33\u00b73%) in the placebo group, hazard ratio (HR) 2\u00b70 (95% CI 0\u00b769-5\u00b79, p = 0\u00b720), indicating no statistically significant protection. Similarly, BCG had no statistically significant effect on COVID-19 (p = 0\u00b763, HR = 1\u00b708, 95% CI 0\u00b782-1\u00b742). Two participants (0\u00b72%) died from COVID-19 and two (0\u00b72%) from other reasons, all in the placebo group.\n\nBCG did not protect healthcare workers from SARS-CoV-2 infection or related severe COVID-19 disease and hospitalisation.\n\nFunding provided by EDCTP, grant number RIA2020EF-2968. Additional funding provided by private donors including: Mediclinic, Calavera Capital (Pty) Ltd, Thys Du Toit, Louis Stassen, The Ryan Foundation, and Dream World Investments 401 (Pty) Ltd. The computations were enabled by resources in project SNIC 2020-5-524 provided by the Swedish National Infrastructure for Computing (SNIC) at UPPMAX, partially funded by the Swedish Research Council through grant agreement No. 2018-05,973.", "doi": "10.1016/j.eclinm.2022.101414", "pmid": "35582122", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(22)00144-4"}, {"db": "pmc", "key": "PMC9098089"}, {"db": "ClinicalTrials.gov", "key": "NCT04379336"}], "notes": [], "created": "2022-06-21T18:04:16.071Z", "modified": "2022-06-21T18:04:16.083Z"}, {"entity": "publication", "iuid": "c5f19680051c403ea6589f082ed762df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5f19680051c403ea6589f082ed762df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5f19680051c403ea6589f082ed762df"}}, "title": "SARS-CoV-2 Omicron variants BA.1 and BA.2 both show similarly reduced disease severity of COVID-19 compared to Delta, Germany, 2021 to 2022.", "authors": [{"family": "Sievers", "given": "Claudia", "initials": "C"}, {"family": "Zacher", "given": "Benedikt", "initials": "B"}, {"family": "Ullrich", "given": "Alexander", "initials": "A"}, {"family": "Huska", "given": "Matthew", "initials": "M"}, {"family": "Fuchs", "given": "Stephan", "initials": "S"}, {"family": "Buda", "given": "Silke", "initials": "S"}, {"family": "Haas", "given": "Walter", "initials": "W"}, {"family": "Diercke", "given": "Michaela", "initials": "M"}, {"family": "An der Heiden", "given": "Matthias", "initials": "M"}, {"family": "Kr\u00f6ger", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "27", "issue": "22", "issn-l": null}, "abstract": "German national surveillance data analysis shows that hospitalisation odds associated with Omicron lineage BA.1 or BA.2 infections are up to 80% lower than with Delta infection, primarily in \u2265 35-year-olds. Hospitalised vaccinated Omicron cases' proportions (2.3% for both lineages) seemed lower than those of the unvaccinated (4.4% for both lineages). Independent of vaccination status, the hospitalisation frequency among cases with Delta seemed nearly threefold higher (8.3%) than with Omicron (3.0% for both lineages), suggesting that Omicron inherently causes less severe disease.", "doi": "10.2807/1560-7917.ES.2022.27.22.2200396", "pmid": "35656831", "labels": {"Category: Omicron VoC": null, "Type: Journal article": null, "Category: Health": null, "Category: Genomics & transcriptomics": null}, "xrefs": [], "notes": [], "created": "2022-06-21T17:18:36.850Z", "modified": "2022-06-21T17:18:55.633Z"}, {"entity": "publication", "iuid": "a33a47868288439ebae157b0221bb4f5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a33a47868288439ebae157b0221bb4f5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a33a47868288439ebae157b0221bb4f5"}}, "title": "Risk of SARS-CoV-2 reinfection and COVID-19 hospitalisation in individuals with natural and hybrid immunity: a retrospective, total population cohort study in Sweden.", "authors": [{"family": "Nordstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Ballin", "given": "Marcel", "initials": "M"}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "volume": "22", "issue": "6", "pages": "781-790", "issn-l": null}, "abstract": "Real-world evidence supporting vaccination against COVID-19 in individuals who have recovered from a previous SARS-CoV-2 infection is sparse. We aimed to investigate the long-term protection from a previous infection (natural immunity) and whether natural immunity plus vaccination (hybrid immunity) was associated with additional protection.\n\nIn this retrospective cohort study, we formed three cohorts using Swedish nationwide registers managed by the Public Health Agency of Sweden, the National Board of Health and Welfare, and Statistics Sweden. Cohort 1 included unvaccinated individuals with natural immunity matched pairwise on birth year and sex to unvaccinated individuals without natural immunity at baseline. Cohort 2 and cohort 3 included individuals vaccinated with one dose (one-dose hybrid immunity) or two doses (two-dose hybrid immunity) of a COVID-19 vaccine, respectively, after a previous infection, matched pairwise on birth year and sex to individuals with natural immunity at baseline. Outcomes of this study were documented SARS-CoV-2 infection from March 20, 2020, until Oct 4, 2021, and inpatient hospitalisation with COVID-19 as main diagnosis from March 30, 2020, until Sept 5, 2021.\n\nCohort 1 was comprised of 2 039 106 individuals, cohort 2 of 962 318 individuals, and cohort 3 of 567 810 individuals. During a mean follow-up of 164 days (SD 100), 34 090 individuals with natural immunity in cohort 1 were registered as having had a SARS-CoV-2 reinfection compared with 99 168 infections in non-immune individuals; the numbers of hospitalisations were 3195 and 1976, respectively. After the first 3 months, natural immunity was associated with a 95% lower risk of SARS-CoV-2 infection (adjusted hazard ratio [aHR] 0\u00b705 [95% CI 0\u00b705-0\u00b705] p<0\u00b7001) and an 87% (0\u00b713 [0\u00b711-0\u00b716]; p<0\u00b7001) lower risk of COVID-19 hospitalisation for up to 20 months of follow-up. During a mean follow-up of 52 days (SD 38) in cohort 2, 639 individuals with one-dose hybrid immunity were registered with a SARS-CoV-2 reinfection, compared with 1662 individuals with natural immunity (numbers of hospitalisations were eight and 113, respectively). One-dose hybrid immunity was associated with a 58% lower risk of SARS-CoV-2 reinfection (aHR 0\u00b742 [95% CI 0\u00b738-0\u00b747]; p<0\u00b7001) than natural immunity up to the first 2 months, with evidence of attenuation thereafter up to 9 months (p<0\u00b7001) of follow-up. During a mean follow-up of 66 days (SD 53) in cohort 3, 438 individuals with two-dose hybrid immunity were registered as having had a SARS-CoV-2 reinfection, compared with 808 individuals with natural immunity (numbers of hospitalisations were six and 40, respectively). Two-dose hybrid immunity was associated with a 66% lower risk of SARS-CoV-2 reinfection (aHR 0\u00b734 [95% CI 0\u00b731-0\u00b739]; p<0\u00b7001) than natural immunity, with no significant attenuation up to 9 months (p=0\u00b707). To prevent one reinfection in the natural immunity cohort during follow-up, 767 individuals needed to be vaccinated with two doses. Both one-dose (HR adjusted for age and baseline date 0\u00b706 [95% CI 0\u00b703-0\u00b712]; p<0\u00b7001) and two-dose (HR adjusted for age and baseline date 0\u00b710 [0\u00b704-0\u00b722]; p<0\u00b7001) hybrid immunity were associated with a lower risk of COVID-19 hospitalisation than natural immunity.\n\nThe risk of SARS-CoV-2 reinfection and COVID-19 hospitalisation in individuals who have survived and recovered from a previous infection remained low for up to 20 months. Vaccination seemed to further decrease the risk of both outcomes for up to 9 months, although the differences in absolute numbers, especially in hospitalisations, were small. These findings suggest that if passports are used for societal restrictions, they should acknowledge either a previous infection or vaccination as proof of immunity, as opposed to vaccination only.\n\nNone.", "doi": "10.1016/S1473-3099(22)00143-8", "pmid": "35366962", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8971363"}, {"db": "pii", "key": "S1473-3099(22)00143-8"}], "notes": [], "created": "2022-04-04T06:21:49.284Z", "modified": "2023-07-13T11:28:04.534Z"}, {"entity": "publication", "iuid": "8151ff7d54534086a1eb2b358c68a32d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8151ff7d54534086a1eb2b358c68a32d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8151ff7d54534086a1eb2b358c68a32d"}}, "title": "Rapidly adapting primary care sentinel surveillance across seven countries in Europe for COVID-19 in the first half of 2020: strengths, challenges, and lessons learned.", "authors": [{"family": "Bagaria", "given": "Jayshree", "initials": "J"}, {"family": "Jansen", "given": "Tessa", "initials": "T"}, {"family": "Marques", "given": "Diogo Fp", "initials": "DF"}, {"family": "Hooiveld", "given": "Mariette", "initials": "M"}, {"family": "McMenamin", "given": "Jim", "initials": "J"}, {"family": "de Lusignan", "given": "Simon", "initials": "S"}, {"family": "Vilcu", "given": "Ana-Maria", "initials": "AM"}, {"family": "Meijer", "given": "Adam", "initials": "A"}, {"family": "Rodrigues", "given": "Ana-Paula", "initials": "AP"}, {"family": "Brytting", "given": "Mia", "initials": "M"}, {"family": "Mazagatos", "given": "Clara", "initials": "C"}, {"family": "Cogdale", "given": "Jade", "initials": "J"}, {"family": "van der Werf", "given": "Sylvie", "initials": "S"}, {"family": "Dijkstra", "given": "Frederika", "initials": "F"}, {"family": "Guiomar", "given": "Raquel", "initials": "R"}, {"family": "Enkirch", "given": "Theresa", "initials": "T"}, {"family": "Valenciano", "given": "Marta", "initials": "M"}, {"family": "I-MOVE-COVID-19 study team", "given": "", "initials": ""}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "27", "issue": "26", "issn-l": null}, "abstract": "As the COVID-19 pandemic began in early 2020, primary care influenza sentinel surveillance networks within the Influenza - Monitoring Vaccine Effectiveness in Europe (I-MOVE) consortium rapidly adapted to COVID-19 surveillance. This study maps system adaptations and lessons learned about aligning influenza and COVID-19 surveillance following ECDC / WHO/Europe recommendations and preparing for other diseases possibly emerging in the future. Using a qualitative approach, we describe the adaptations of seven sentinel sites in five European Union countries and the United Kingdom during the first pandemic phase (March-September 2020). Adaptations to sentinel systems were substantial (2/7 sites), moderate (2/7) or minor (3/7 sites). Most adaptations encompassed patient referral and sample collection pathways, laboratory testing and data collection. Strengths included established networks of primary care providers, highly qualified testing laboratories and stakeholder commitments. One challenge was the decreasing number of samples due to altered patient pathways. Lessons learned included flexibility establishing new routines and new laboratory testing. To enable simultaneous sentinel surveillance of influenza and COVID-19, experiences of the sentinel sites and testing infrastructure should be considered. The contradicting aims of rapid case finding and contact tracing, which are needed for control during a pandemic and regular surveillance, should be carefully balanced.", "doi": "10.2807/1560-7917.ES.2022.27.26.2100864", "pmid": "35775429", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9248262"}], "notes": [], "created": "2022-08-17T13:12:39.666Z", "modified": "2022-08-17T13:12:39.680Z"}, {"entity": "publication", "iuid": "21ddc26f77ed4aa39fe287b3b80f6cc8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/21ddc26f77ed4aa39fe287b3b80f6cc8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/21ddc26f77ed4aa39fe287b3b80f6cc8"}}, "title": "Prevalence of gaming addiction and its impact on sleep quality: A cross-sectional study from Pakistan.", "authors": [{"family": "Zaman", "given": "Musharaf", "initials": "M"}, {"family": "Babar", "given": "Muhammad Saad", "initials": "MS"}, {"family": "Babar", "given": "Maryam", "initials": "M"}, {"family": "Sabir", "given": "Faheem", "initials": "F"}, {"family": "Ashraf", "given": "Farzana", "initials": "F"}, {"family": "Tahir", "given": "Muhammad Junaid", "initials": "MJ"}, {"family": "Ullah", "given": "Irfan", "initials": "I"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Ann Med Surg (Lond)", "issn": "2049-0801", "volume": "78", "pages": "103641", "issn-l": null}, "abstract": "Gaming addiction has become a topic of increasing research interest worldwide but little research has been carried out in Pakistan.\n\nThe present study assessed the prevalence of gaming addiction among a Pakistani sample of adults in the general population. It also explored the effects of online gaming addiction upon sleep quality.\n\nA cross-sectional survey was carried out during a national lockdown due to the COVID-19 pandemic in Pakistan. Using a convenience sampling technique, an online survey comprising demographic information, the Game Addiction Scale (GAS), and the Pittsburgh Sleep Quality Index (PSQI) was completed by 618 participants (67.5% male) aged 18-56 years (M = 24.53 years, SD = \u00b15.016).\n\nOut of 618 participants, 57.0% (n=352) played online games. Among gamers, 12.5% (n = 44) were classed as addicted to the gaming based on GAS scores. Compared to those not addicted to gaming, participants with gaming addiction had significantly poorer subjective sleep quality, higher sleep disturbance, lesser sleep duration, and higher daytime dysfunction. Gaming addiction was also more prevalent among males compared to females.\n\nGaming addiction among the Pakistani general population is significantly associated with poor sleep quality. This problem needs to be addressed at both individual and societal levels to avoid adverse long-term health impacts.", "doi": "10.1016/j.amsu.2022.103641", "pmid": "35734653", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2049-0801(22)00401-0"}, {"db": "pmc", "key": "PMC9206897"}], "notes": [], "created": "2022-08-19T05:52:20.807Z", "modified": "2022-08-19T05:52:20.821Z"}, {"entity": "publication", "iuid": "be40558f2b164b9fa6df518204e5e100", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be40558f2b164b9fa6df518204e5e100.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be40558f2b164b9fa6df518204e5e100"}}, "title": "Nurses' lived experiences of caring for patients with COVID-19: a phenomenological study.", "authors": [{"family": "Heydarikhayat", "given": "Nastaran", "initials": "N", "orcid": "0000-0001-9564-325X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dade1d8864584096b8ae0c4e8d3e2653.json"}}, {"family": "Ghanbarzehi", "given": "Nezar", "initials": "N"}, {"family": "Shahkaramzehi", "given": "Zarkhatoon", "initials": "Z"}, {"family": "Sabagh", "given": "Kimya", "initials": "K"}, {"family": "Rohani", "given": "Camelia", "initials": "C"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "J Res Nurs", "issn": "1744-988X", "volume": "27", "issue": "4", "pages": "313-327", "issn-l": null}, "abstract": "COVID-19 is an infectious disease caused by a novel Coronavirus which transmits from person to person throughout the world. This study aimed to explore the lived experiences of nurses' caring for patients with COVID-2019 in the context of the healthcare system of Iran.\n\nThis is a phenomenological study with 13 participant nurses (6 men and 7 women) who were caring for COVID-19 patients in one of the university hospitals in Southeast of Iran. Qualitative data were analysed by the seven steps of Colaizzi's method.\n\nParticipants reported around a five-month history of caring for COVID-19 patients. After analysis, 597 codes, 16 categories, four sub-themes, and one theme were extracted. \"Caring from self-sacrifice to avoidance\" was the main theme of the study with sub-themes of \"Anxiety Chain\", \"Manifestation of Humanitarian Caring\", \"Ethical Challenges\", and \"Challenges of Overcoming Crisis\".\n\nNurses explained their caring experiences with patients on a continuum from humanitarian caring and self-sacrifice to caring avoidance. Because of the multi-sources of psychological stress and ethical challenges together with this infection, healthcare managers should plan for holistic regular psychological support services, prevention of job inequalities, and do strategic planning for access to enough resources in the healthcare system.", "doi": "10.1177/17449871221079175", "pmid": "35837262", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1177_17449871221079175"}, {"db": "pmc", "key": "PMC9272502"}], "notes": [], "created": "2022-08-12T08:59:13.287Z", "modified": "2022-08-12T08:59:13.361Z"}, {"entity": "publication", "iuid": "993a589aaded439bbb88d6ff12b792cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/993a589aaded439bbb88d6ff12b792cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/993a589aaded439bbb88d6ff12b792cb"}}, "title": "Neutralisation sensitivity of the SARS-CoV-2 omicron (B.1.1.529) variant: a cross-sectional study.", "authors": [{"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Kim", "given": "Changil", "initials": "C"}, {"family": "Ehling", "given": "Roy A", "initials": "RA"}, {"family": "Pankow", "given": "Alec", "initials": "A"}, {"family": "Castro Dopico", "given": "Xaquin", "initials": "X"}, {"family": "Dyrdak", "given": "Robert", "initials": "R", "orcid": "0000-0001-8456-4898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98ad76a0e144478cb3ceabd05c9928b0.json"}}, {"family": "Martin", "given": "Darren P", "initials": "DP"}, {"family": "Reddy", "given": "Sai T", "initials": "ST"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Murrell", "given": "Ben", "initials": "B"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "issn-l": null, "volume": "22", "issue": "6", "pages": "813-820"}, "abstract": "The SARS-CoV-2 omicron (B.1.1.529) variant, which was first identified in November, 2021, spread rapidly in many countries, with a spike protein highly diverged from previously known variants, and raised concerns that this variant might evade neutralising antibody responses. We therefore aimed to characterise the sensitivity of the omicron variant to neutralisation.\n\nFor this cross-sectional study, we cloned the sequence encoding the omicron spike protein from a diagnostic sample to establish an omicron pseudotyped virus neutralisation assay. We quantified the neutralising antibody ID50 (the reciprocal dilution that produces 50% inhibition) against the omicron spike protein, and the fold-change in ID50 relative to the spike of wild-type SARS-CoV-2 (ie, the pandemic founder variant), for one convalescent reference plasma pool (WHO International Standard for anti-SARS-CoV-2 immunoglobulin [20/136]), three reference serum pools from vaccinated individuals, and two cohorts from Stockholm, Sweden: one comprising previously infected hospital workers (17 sampled in November, 2021, after vaccine rollout and nine in June or July, 2020, before vaccination) and one comprising serum from 40 randomly sampled blood donors donated during week 48 (Nov 29-Dec 5) of 2021. Furthermore, we assessed the neutralisation of omicron by five clinically relevant monoclonal antibodies (mAbs).\n\nNeutralising antibody responses in reference sample pools sampled shortly after infection or vaccination were substantially less potent against the omicron variant than against wild-type SARS-CoV-2 (seven-fold to 42-fold reduction in ID50 titres). Similarly, for sera obtained before vaccination in 2020 from a cohort of convalescent hospital workers, neutralisation of the omicron variant was low to undetectable (all ID50 titres <20). However, in serum samples obtained in 2021 from two cohorts in Stockholm, substantial cross-neutralisation of the omicron variant was observed. Sera from 17 hospital workers after infection and subsequent vaccination had a reduction in average potency of only five-fold relative to wild-type SARS-CoV-2 (geometric mean ID50 titre 495 vs 105), and two donors had no reduction in potency. A similar pattern was observed in randomly sampled blood donors (n=40), who had an eight-fold reduction in average potency against the omicron variant compared with wild-type SARS-CoV-2 (geometric mean ID50 titre 369 vs 45). We found that the omicron variant was resistant to neutralisation (50% inhibitory concentration [IC50] >10 \u03bcg/mL) by mAbs casirivimab (REGN-10933), imdevimab (REGN-10987), etesevimab (Ly-CoV016), and bamlanivimab (Ly-CoV555), which form part of antibody combinations used in the clinic to treat COVID-19. However, S309, the parent of sotrovimab, retained most of its activity, with only an approximately two-fold reduction in potency against the omicron variant compared with ancestral D614G SARS-CoV-2 (IC50 0\u00b71-0\u00b72 \u03bcg/mL).\n\nThese data highlight the extensive, but incomplete, evasion of neutralising antibody responses by the omicron variant, and suggest that boosting with licensed vaccines might be sufficient to raise neutralising antibody titres to protective levels.\n\nEuropean Union Horizon 2020 research and innovation programme, European and Developing Countries Clinical Trials Partnership, SciLifeLab, and the Erling-Persson Foundation.", "doi": "10.1016/S1473-3099(22)00129-3", "pmid": "35305699", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Omicron VoC": null}, "xrefs": [{"db": "pmc", "key": "PMC8930016"}, {"db": "pii", "key": "S1473-3099(22)00129-3"}], "notes": [], "created": "2022-01-21T16:18:07.075Z", "modified": "2023-06-19T14:45:01.450Z"}, {"entity": "publication", "iuid": "bfb6d404efd348beb404a6db8b205e69", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bfb6d404efd348beb404a6db8b205e69.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bfb6d404efd348beb404a6db8b205e69"}}, "title": "Modelling: Understanding pandemics and how to control them.", "authors": [{"family": "Marion", "given": "Glenn", "initials": "G"}, {"family": "Hadley", "given": "Liza", "initials": "L"}, {"family": "Isham", "given": "Valerie", "initials": "V"}, {"family": "Mollison", "given": "Denis", "initials": "D"}, {"family": "Panovska-Griffiths", "given": "Jasmina", "initials": "J"}, {"family": "Pellis", "given": "Lorenzo", "initials": "L"}, {"family": "Tomba", "given": "Gianpaolo Scalia", "initials": "GS"}, {"family": "Scarabel", "given": "Francesca", "initials": "F"}, {"family": "Swallow", "given": "Ben", "initials": "B"}, {"family": "Trapman", "given": "Pieter", "initials": "P", "orcid": "0000-0003-0569-1659", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a2df9c9216143cd8219de8687414709.json"}}, {"family": "Villela", "given": "Daniel", "initials": "D"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Epidemics", "issn": "1878-0067", "volume": "39", "pages": "100588", "issn-l": null}, "abstract": "New disease challenges, societal demands and better or novel types of data, drive innovations in the structure, formulation and analysis of epidemic models. Innovations in modelling can lead to new insights into epidemic processes and better use of available data, yielding improved disease control and stimulating collection of better data and new data types. Here we identify key challenges for the structure, formulation, analysis and use of mathematical models of pathogen transmission relevant to current and future pandemics.", "doi": "10.1016/j.epidem.2022.100588", "pmid": "35679714", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1755-4365(22)00035-4"}], "notes": [], "created": "2022-06-20T19:29:13.358Z", "modified": "2023-06-19T15:26:45.081Z"}, {"entity": "publication", "iuid": "866944d064874e18a373935bdfbc15c2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/866944d064874e18a373935bdfbc15c2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/866944d064874e18a373935bdfbc15c2"}}, "title": "Modelling preventive measures and their effect on generation times in emerging epidemics.", "authors": [{"family": "Favero", "given": "Martina", "initials": "M", "orcid": "0000-0002-7069-9721", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2db3da80e42141af9f697718f71caa5a.json"}}, {"family": "Scalia Tomba", "given": "Gianpaolo", "initials": "G", "orcid": "0000-0001-6581-8661", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dae7fb6267504aff8ca1f6a05c0b40aa.json"}}, {"family": "Britton", "given": "Tom", "initials": "T", "orcid": "0000-0002-9228-7357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3953e83bbffb428ab0a02f335979acb2.json"}}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "J R Soc Interface", "issn": "1742-5662", "volume": "19", "issue": "191", "pages": "20220128", "issn-l": null}, "abstract": "We present a stochastic epidemic model to study the effect of various preventive measures, such as uniform reduction of contacts and transmission, vaccination, isolation, screening and contact tracing, on a disease outbreak in a homogeneously mixing community. The model is based on an infectivity process, which we define through stochastic contact and infectiousness processes, so that each individual has an independent infectivity profile. In particular, we monitor variations of the reproduction number and of the distribution of generation times. We show that some interventions, i.e. uniform reduction and vaccination, affect the former while leaving the latter unchanged, whereas other interventions, i.e. isolation, screening and contact tracing, affect both quantities. We provide a theoretical analysis of the variation of these quantities, and we show that, in practice, the variation of the generation time distribution can be significant and that it can cause biases in the estimation of reproduction numbers. The framework, because of its general nature, captures the properties of many infectious diseases, but particular emphasis is on COVID-19, for which numerical results are provided.", "doi": "10.1098/rsif.2022.0128", "pmid": "35702865", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9198515"}], "notes": [], "created": "2022-06-20T18:13:38.873Z", "modified": "2022-08-17T13:01:07.267Z"}, {"entity": "publication", "iuid": "e712b712c9b54d0e93648c3e905903b6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e712b712c9b54d0e93648c3e905903b6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e712b712c9b54d0e93648c3e905903b6"}}, "title": "Impact of COVID-19 on palliative care of cancer patients: Perspectives from Pakistan.", "authors": [{"family": "Saeed", "given": "Sajeel", "initials": "S"}, {"family": "Tousif", "given": "Kashif", "initials": "K"}, {"family": "Fatir", "given": "Chaudhary Abdul", "initials": "CA"}, {"family": "Basit", "given": "Jawad", "initials": "J"}, {"family": "Lee", "given": "Ka Yiu", "initials": "KY"}, {"family": "Tahir", "given": "Muhammad Junaid", "initials": "MJ"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Ann Med Surg (Lond)", "issn": "2049-0801", "volume": "78", "pages": "103705", "issn-l": null}, "abstract": "The COVID-19 pandemic has adversely affected the survival rate and palliative care of cancer patients all over the globe. In Pakistan, there are only a few institutions and organizations which provide specialized facilities for palliative care. During the pandemic, these specialized facilities were further limited. As only less than one percent of people had access to palliative care across Pakistan in the pandemic, the situation can be improved by establishing more such departments, providing telemedicine, increasing social media campaigns, and highlighting the importance of palliative care among cancer patients.", "doi": "10.1016/j.amsu.2022.103705", "pmid": "35582458", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2049-0801(22)00465-4"}, {"db": "pmc", "key": "PMC9098974"}], "notes": [], "created": "2022-06-21T18:03:47.165Z", "modified": "2022-06-21T18:03:47.182Z"}, {"entity": "publication", "iuid": "981bd96ab70447d18b1d57b7dc047104", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/981bd96ab70447d18b1d57b7dc047104.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/981bd96ab70447d18b1d57b7dc047104"}}, "title": "Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19.", "authors": [{"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Grip", "given": "Jonathan", "initials": "J"}, {"family": "Lindel\u00f6f", "given": "Linnea", "initials": "L", "orcid": "0000-0002-3654-8874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b0581b9ebda046fdaf4b3c14b0b910a9.json"}}, {"family": "Rooijackers", "given": "Olav", "initials": "O"}, {"family": "Pigazzini", "given": "Sara", "initials": "S"}, {"family": "Niemi", "given": "Mari", "initials": "M"}, {"family": "Cordioli", "given": "Mattia", "initials": "M"}, {"family": "Nkambule", "given": "Lindo", "initials": "L"}, {"family": "Maricic", "given": "Tomislav", "initials": "T"}, {"family": "Ekdahl", "given": "Kristina Nilsson", "initials": "KN"}, {"family": "Nilsson", "given": "Bo", "initials": "B"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ee1510080704cf6a2a6972deb94123f.json"}}, {"family": "Eriksson", "given": "Oskar", "initials": "O", "orcid": "0000-0003-2418-6463", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d2b881e96504b58a64ea3fd004c5d18.json"}}], "type": "letter", "published": "2022-06-00", "journal": {"title": "Nat Immunol", "issn": "1529-2916", "issn-l": null, "volume": "23", "issue": "6", "pages": "861-864"}, "abstract": null, "doi": "10.1038/s41590-022-01227-w", "pmid": "35624204", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41590-022-01227-w"}], "notes": [], "created": "2022-06-21T17:43:29.723Z", "modified": "2022-08-19T12:34:29.000Z"}, {"entity": "publication", "iuid": "d96a9d8d55d344d19b36ea7aeb1f78f5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d96a9d8d55d344d19b36ea7aeb1f78f5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d96a9d8d55d344d19b36ea7aeb1f78f5"}}, "title": "Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study.", "authors": [{"family": "Greco", "given": "Massimiliano", "initials": "M", "orcid": "0000-0003-1003-4637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a25a0febf83948fc8d35a2e4122f321c.json"}}, {"family": "De Corte", "given": "Thomas", "initials": "T", "orcid": "0000-0001-5011-6640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5901255b86c34191815e106debb8a64c.json"}}, {"family": "Ercole", "given": "Ari", "initials": "A", "orcid": "0000-0001-8350-8093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3aaf57ce5a454b7aa5343bbc0462d85b.json"}}, {"family": "Antonelli", "given": "Massimo", "initials": "M", "orcid": "0000-0003-3007-1670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9cdf5e76c1ee43a896a77d6055ae6a10.json"}}, {"family": "Azoulay", "given": "Elie", "initials": "E", "orcid": "0000-0002-8162-1508", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be149aab02dd48498b6b008e119f9946.json"}}, {"family": "Citerio", "given": "Giuseppe", "initials": "G", "orcid": "0000-0002-5374-3161", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/629ff9a17f4647e5af326467b1252214.json"}}, {"family": "Morris", "given": "Andy Conway", "initials": "AC", "orcid": "0000-0002-3211-3216", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f541174f24a5466e96a094b94e42de72.json"}}, {"family": "De Pascale", "given": "Gennaro", "initials": "G", "orcid": "0000-0002-8255-0676", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7866bbe8ae614536bb2a80070212035d.json"}}, {"family": "Duska", "given": "Frantisek", "initials": "F", "orcid": "0000-0003-1559-4078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e34c8d87b5f491ba0e1cd8760db70b0.json"}}, {"family": "Elbers", "given": "Paul", "initials": "P", "orcid": "0000-0003-0447-6893", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dec9d09090cb428bbbbc3a90bf5b1ab1.json"}}, {"family": "Einav", "given": "Sharon", "initials": "S", "orcid": "0000-0001-8963-9633", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7741185472c46dcac6fc1cf5c6b9083.json"}}, {"family": "Forni", "given": "Lui", "initials": "L", "orcid": "0000-0002-0617-5309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33324a9a38a94578acb4522d84c2ded6.json"}}, {"family": "Galarza", "given": "Laura", "initials": "L", "orcid": "0000-0002-4658-748X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82e734919a2045e480995be7adab3fed.json"}}, {"family": "Girbes", "given": "Armand R J", "initials": "ARJ", "orcid": "0000-0002-0711-0494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/879982b05a1848e39c9d5f0fbde801ec.json"}}, {"family": "Grasselli", "given": "Giacomo", "initials": "G", "orcid": "0000-0002-1735-1400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a68eafa11dae413bb14842cfb8647144.json"}}, {"family": "Gusarov", "given": "Vitaly", "initials": "V", "orcid": "0000-0002-2900-1459", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/896c47a24ca94c99b7fa50513fc9387b.json"}}, {"family": "Jubb", "given": "Alasdair", "initials": "A", "orcid": "0000-0001-5593-866X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2d88d0265f54a06aea8ebdf39e2df86.json"}}, {"family": "Kesecioglu", "given": "Jozef", "initials": "J", "orcid": "0000-0002-3007-8445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9af039f78ddc46b29b25b2b337c8a01e.json"}}, {"family": "Lavinio", "given": "Andrea", "initials": "A", "orcid": "0000-0002-8832-918X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a358df8988744dd99f5aecaac0e4a850.json"}}, {"family": "Delgado", "given": "Maria Cruz Martin", "initials": "MCM", "orcid": "0000-0002-7468-4594", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7eef2e9011c4281b952175a824b9f4a.json"}}, {"family": "Mellinghoff", "given": "Johannes", "initials": "J", "orcid": "0000-0002-5455-8953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37ddf15c796a4c2ea172764a6c36f9d0.json"}}, {"family": "Myatra", "given": "Sheila Nainan", "initials": "SN", "orcid": "0000-0001-6761-163X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80f906419daa4f5e87a1c6f7a9b554af.json"}}, {"family": "Ostermann", "given": "Marlies", "initials": "M", "orcid": "0000-0001-9500-9080", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc42fc57504149a29d3ffef5efd9852c.json"}}, {"family": "Pellegrini", "given": "Mariangela", "initials": "M", "orcid": "0000-0001-5668-7399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/97386683452a4afd9e1da948bb9921f2.json"}}, {"family": "Povoa", "given": "Pedro", "initials": "P", "orcid": "0000-0002-7069-7304", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93f2b9dbca90480eb98555b44c69ef58.json"}}, {"family": "Schaller", "given": "Stefan J", "initials": "SJ", "orcid": "0000-0002-6683-9584", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5c134bb75e14b94bc723f59b7dd790e.json"}}, {"family": "Teboul", "given": "Jean-Louis", "initials": "JL", "orcid": "0000-0002-5748-7820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbd174ebc7444e769fc5fd03e9689c21.json"}}, {"family": "Wong", "given": "Adrian", "initials": "A", "orcid": "0000-0003-4968-7328", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/338f961fbb48481f893f697e5dfc1d67.json"}}, {"family": "De Waele", "given": "Jan J", "initials": "JJ", "orcid": "0000-0003-1017-9748", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/875fffe346d548b19bd3c0e0ff6fb267.json"}}, {"family": "Cecconi", "given": "Maurizio", "initials": "M", "orcid": "0000-0002-4376-6538", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79162e2a5da843ee9de35265eacc1d93.json"}}, {"family": "ESICM UNITE-COVID investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "volume": "48", "issue": "6", "pages": "690-705", "issn-l": "0342-4642"}, "abstract": "To accommodate the unprecedented number of critically ill patients with pneumonia caused by coronavirus disease 2019 (COVID-19) expansion of the capacity of intensive care unit (ICU) to clinical areas not previously used for critical care was necessary. We describe the global burden of COVID-19 admissions and the clinical and organizational characteristics associated with outcomes in critically ill COVID-19 patients.\n\nMulticenter, international, point prevalence study, including adult patients with SARS-CoV-2 infection confirmed by polymerase chain reaction (PCR) and a diagnosis of COVID-19 admitted to ICU between February 15th and May 15th, 2020.\n\n4994 patients from 280 ICUs in 46 countries were included. Included ICUs increased their total capacity from 4931 to 7630 beds, deploying personnel from other areas. Overall, 1986 (39.8%) patients were admitted to surge capacity beds. Invasive ventilation at admission was present in 2325 (46.5%) patients and was required during ICU stay in 85.8% of patients. 60-day mortality was 33.9% (IQR across units: 20%-50%) and ICU mortality 32.7%. Older age, invasive mechanical ventilation, and acute kidney injury (AKI) were associated with increased mortality. These associations were also confirmed specifically in mechanically ventilated patients. Admission to surge capacity beds was not associated with mortality, even after controlling for other factors.\n\nICUs responded to the increase in COVID-19 patients by increasing bed availability and staff, admitting up to 40% of patients in surge capacity beds. Although mortality in this population was high, admission to a surge capacity bed was not associated with increased mortality. Older age, invasive mechanical ventilation, and AKI were identified as the strongest predictors of mortality.", "doi": "10.1007/s00134-022-06705-1", "pmid": "35596752", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-022-06705-1"}, {"db": "pmc", "key": "PMC9123859"}], "notes": [], "created": "2022-06-21T17:59:43.200Z", "modified": "2022-06-21T17:59:44.237Z"}, {"entity": "publication", "iuid": "eadd3298440b494c933cb8991a2e96c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eadd3298440b494c933cb8991a2e96c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eadd3298440b494c933cb8991a2e96c0"}}, "title": "An early warning system for emerging SARS-CoV-2 variants.", "authors": [{"family": "Subissi", "given": "Lorenzo", "initials": "L", "orcid": "0000-0001-5147-575X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/454c226e834a4829a330df1c4b604855.json"}}, {"family": "von Gottberg", "given": "Anne", "initials": "A", "orcid": "0000-0002-0243-7455", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa3e854c50af4dbeb6b3c51c8feca226.json"}}, {"family": "Thukral", "given": "Lipi", "initials": "L"}, {"family": "Worp", "given": "Nathalie", "initials": "N"}, {"family": "Oude Munnink", "given": "Bas B", "initials": "BB", "orcid": "0000-0002-9394-1189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19923669d04a47ebb5c7c93d20ecedc3.json"}}, {"family": "Rathore", "given": "Surabhi", "initials": "S"}, {"family": "Abu-Raddad", "given": "Laith J", "initials": "LJ", "orcid": "0000-0003-0790-0506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebbd58612cec4b76aa8f00efc37adefb.json"}}, {"family": "Aguilera", "given": "Ximena", "initials": "X", "orcid": "0000-0002-8153-6733", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be3f762e99094b86b5873d7b44d24a03.json"}}, {"family": "Alm", "given": "Erik", "initials": "E"}, {"family": "Archer", "given": "Brett N", "initials": "BN", "orcid": "0000-0002-4144-1094", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3fb24f334b94306aa5d64c193980852.json"}}, {"family": "Attar Cohen", "given": "Homa", "initials": "H"}, {"family": "Barakat", "given": "Amal", "initials": "A"}, {"family": "Barclay", "given": "Wendy S", "initials": "WS", "orcid": "0000-0002-3948-0895", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a6c3e7314d645c09435f54ee0e6046d.json"}}, {"family": "Bhiman", "given": "Jinal N", "initials": "JN", "orcid": "0000-0001-6354-4003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a8c04d1addc4cbd9bc0624e709c5fb6.json"}}, {"family": "Caly", "given": "Leon", "initials": "L"}, {"family": "Chand", "given": "Meera", "initials": "M"}, {"family": "Chen", "given": "Mark", "initials": "M"}, {"family": "Cullinane", "given": "Ann", "initials": "A"}, {"family": "de Oliveira", "given": "Tulio", "initials": "T"}, {"family": "Drosten", "given": "Christian", "initials": "C", "orcid": "0000-0001-7923-0519", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5181b233d41d4c708b9dce7e74e22f6d.json"}}, {"family": "Druce", "given": "Julian", "initials": "J"}, {"family": "Effler", "given": "Paul", "initials": "P"}, {"family": "El Masry", "given": "Ihab", "initials": "I"}, {"family": "Faye", "given": "Adama", "initials": "A"}, {"family": "Gaseitsiwe", "given": "Simani", "initials": "S"}, {"family": "Ghedin", "given": "Elodie", "initials": "E", "orcid": "0000-0002-1515-725X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ffc96a3fefb4b158fbdc240b18d5149.json"}}, {"family": "Grant", "given": "Rebecca", "initials": "R"}, {"family": "Haagmans", "given": "Bart L", "initials": "BL", "orcid": "0000-0001-6221-2015", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96a8b5e7b73b4998a3c4da5af2181538.json"}}, {"family": "Herring", "given": "Belinda L", "initials": "BL"}, {"family": "Iyer", "given": "Shilpa S", "initials": "SS"}, {"family": "Kassamali", "given": "Zyleen", "initials": "Z", "orcid": "0000-0002-0668-7099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a23574374f264895b8e0ccc9141ec987.json"}}, {"family": "Kakkar", "given": "Manish", "initials": "M", "orcid": "0000-0002-3254-0496", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c3289180dbad4089ab3e557fe14174c8.json"}}, {"family": "Kondor", "given": "Rebecca J", "initials": "RJ"}, {"family": "Leite", "given": "Juliana A", "initials": "JA", "orcid": "0000-0002-8620-114X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0ef59c86dbb441594c9bb03f9083122.json"}}, {"family": "Leo", "given": "Yee-Sin", "initials": "YS", "orcid": "0000-0003-4978-5825", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ca28661a9df44a7b95577da156b54c9.json"}}, {"family": "Leung", "given": "Gabriel M", "initials": "GM"}, {"family": "Marklewitz", "given": "Marco", "initials": "M", "orcid": "0000-0003-1828-8770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08f8a32079f24efb8e4850ac02019606.json"}}, {"family": "Moyo", "given": "Sikhulile", "initials": "S", "orcid": "0000-0003-3821-4592", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24e198ad74e84883a5d79eb36c8df68c.json"}}, {"family": "Mendez-Rico", "given": "Jairo", "initials": "J"}, {"family": "Melhem", "given": "Nada M", "initials": "NM", "orcid": "0000-0002-5423-4908", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80d02c8de4a74f268f26ef9ef1079845.json"}}, {"family": "Munster", "given": "Vincent", "initials": "V", "orcid": "0000-0002-2288-3196", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1f2569e7fe5442d968b3d89c88599d1.json"}}, {"family": "Nahapetyan", "given": "Karen", "initials": "K"}, {"family": "Oh", "given": "Djin-Ye", "initials": "DY"}, {"family": "Pavlin", "given": "Boris I", "initials": "BI"}, {"family": "Peacock", "given": "Thomas P", "initials": "TP", "orcid": "0000-0001-7077-2928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/940835adb42b431a882f9af9acf166f7.json"}}, {"family": "Peiris", "given": "Malik", "initials": "M", "orcid": "0000-0001-8217-5995", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9395f3f6fc44427b0dbf04988bfde22.json"}}, {"family": "Peng", "given": "Zhibin", "initials": "Z"}, {"family": "Poon", "given": "Leo L M", "initials": "LLM", "orcid": "0000-0002-9101-7953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6595eec1d268410fad9018a8c7dd20c6.json"}}, {"family": "Rambaut", "given": "Andrew", "initials": "A", "orcid": "0000-0003-4337-3707", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d25e62e17c243f3ab72304ca504e296.json"}}, {"family": "Sacks", "given": "Jilian", "initials": "J"}, {"family": "Shen", "given": "Yinzhong", "initials": "Y"}, {"family": "Siqueira", "given": "Marilda M", "initials": "MM"}, {"family": "Tessema", "given": "Sofonias K", "initials": "SK"}, {"family": "Volz", "given": "Erik M", "initials": "EM", "orcid": "0000-0001-6268-8937", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9be67903cdcf4953b8905562984517e8.json"}}, {"family": "Thiel", "given": "Volker", "initials": "V", "orcid": "0000-0002-5783-0887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c6d7b184da743e5975d3009cad5a802.json"}}, {"family": "van der Werf", "given": "Sylvie", "initials": "S", "orcid": "0000-0002-1148-4456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/610e999fc3fa4d24aceecf5a13122ecf.json"}}, {"family": "Briand", "given": "Sylvie", "initials": "S"}, {"family": "Perkins", "given": "Mark D", "initials": "MD"}, {"family": "Van Kerkhove", "given": "Maria D", "initials": "MD", "orcid": "0000-0002-6135-0018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/217da117247b46428c2f5ea15c3f1bf9.json"}}, {"family": "Koopmans", "given": "Marion P G", "initials": "MPG", "orcid": "0000-0002-5204-2312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80d7f1e97b934289b7095013ef6e998d.json"}}, {"family": "Agrawal", "given": "Anurag", "initials": "A"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "volume": "28", "issue": "6", "pages": "1110-1115", "issn-l": "1078-8956"}, "abstract": null, "doi": "10.1038/s41591-022-01836-w", "pmid": "35637337", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-022-01836-w"}], "notes": [], "created": "2022-06-21T17:38:16.669Z", "modified": "2022-06-21T17:38:32.806Z"}, {"entity": "publication", "iuid": "c7a44b6b483f4fe0a665c19900fdacb3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7a44b6b483f4fe0a665c19900fdacb3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7a44b6b483f4fe0a665c19900fdacb3"}}, "title": "The chimera of S1 and N proteins of SARS-CoV-2: can it be a potential vaccine candidate for COVID-19?", "authors": [{"family": "Kumar", "given": "Amresh", "initials": "A"}, {"family": "Ladha", "given": "Amit", "initials": "A"}, {"family": "Choudhury", "given": "Ankita", "initials": "A"}, {"family": "Ikbal", "given": "Abu Md Ashif", "initials": "AMA"}, {"family": "Bhattacharjee", "given": "Bedanta", "initials": "B"}, {"family": "Das", "given": "Tanmay", "initials": "T"}, {"family": "Gupta", "given": "Gaurav", "initials": "G"}, {"family": "Sharma", "given": "Chhavi", "initials": "C"}, {"family": "Sarbajna", "given": "Adity", "initials": "A"}, {"family": "Mandal", "given": "Subhash C", "initials": "SC"}, {"family": "Choudhury", "given": "Manabendra Dutta", "initials": "MD"}, {"family": "Ali", "given": "Nahid", "initials": "N"}, {"family": "Slama", "given": "Petr", "initials": "P"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Palit", "given": "Partha", "initials": "P"}, {"family": "Tiwari", "given": "Onkar Nath", "initials": "ON"}], "type": "journal article", "published": "2022-05-31", "journal": {"title": "Expert Rev Vaccines", "issn": "1744-8395", "pages": "1-16", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as one of the biggest global health issues. Spike protein (S) and nucleoprotein (N), the major immunogenic components of SARS-CoV-2, have been shown to be involved in the attachment and replication of the virus inside the host cell.\n\nSeveral investigations have shown that the SARS-CoV-2 nucleoprotein can elicit a cell-mediated immune response capable of regulating viral replication and lowering viral burden. However, the development of an effective vaccine that can stop the transmission of SARS-CoV-2 remains a matter of concern. Literature was retrieved using the keywords COVID-19 vaccine, role of nucleoprotein as vaccine candidate, spike protein, nucleoprotein immune responses against SARS-CoV-2, and chimera vaccine in PubMed, Google Scholar, and Google.\n\nWe have focussed on the use of chimera protein, consisting of N and S-1 protein components of SARS-CoV-2, as a potential vaccine candidate. This may act as a polyvalent mixed recombinant protein vaccine to elicit a strong T and B cell immune response, which will be capable of neutralizing the wild and mutated variants of SARS-CoV-2, and also restricting its attachment, replication, and budding in the host cell.", "doi": "10.1080/14760584.2022.2081156", "pmid": "35604776", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T17:53:36.946Z", "modified": "2022-06-21T17:53:36.980Z"}, {"entity": "publication", "iuid": "1595cf333fbb4fde88159a514e865a3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1595cf333fbb4fde88159a514e865a3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1595cf333fbb4fde88159a514e865a3d"}}, "title": "Guidelines for Perioperative Care in Elective Abdominal and Pelvic Surgery at Primary and Secondary Hospitals in Low-Middle-Income Countries (LMIC's): Enhanced Recovery After Surgery (ERAS) Society Recommendation.", "authors": [{"family": "Oodit", "given": "Ravi", "initials": "R"}, {"family": "Biccard", "given": "Bruce M", "initials": "BM"}, {"family": "Panieri", "given": "Eugenio", "initials": "E"}, {"family": "Alvarez", "given": "Adrian O", "initials": "AO"}, {"family": "Sioson", "given": "Marianna R S", "initials": "MRS"}, {"family": "Maswime", "given": "Salome", "initials": "S"}, {"family": "Thomas", "given": "Viju", "initials": "V"}, {"family": "Kluyts", "given": "Hyla-Louise", "initials": "HL"}, {"family": "Peden", "given": "Carol J", "initials": "CJ"}, {"family": "de Boer", "given": "Hans D", "initials": "HD"}, {"family": "Brindle", "given": "Mary", "initials": "M"}, {"family": "Francis", "given": "Nader K", "initials": "NK"}, {"family": "Nelson", "given": "Gregg", "initials": "G"}, {"family": "Gustafsson", "given": "Ulf O", "initials": "UO"}, {"family": "Ljungqvist", "given": "Olle", "initials": "O"}], "type": "journal article", "published": "2022-05-31", "journal": {"title": "World J Surg", "issn": "1432-2323", "issn-l": null}, "abstract": "This is the first Enhanced Recovery After Surgery (ERAS\u00ae) Society guideline for primary and secondary hospitals in low-middle-income countries (LMIC's) for elective abdominal and gynecologic care.\n\nThe ERAS LMIC Guidelines group was established by the ERAS\u00ae Society in collaboration with different representatives of perioperative care from LMIC's. The group consisted of seven members from the ERAS\u00ae Society and eight members from LMIC's. An updated systematic literature search and evaluation of evidence from previous ERAS\u00ae guidelines was performed by the leading authors of the Colorectal (2018) and Gynecologic (2019) surgery guidelines (Gustafsson et al in World J Surg 43:6592-695, Nelson et al in Int J Gynecol Cancer 29(4):651-668). Meta-analyses randomized controlled trials (RCTs), prospective and retrospective cohort studies from both HIC's and LMIC's were considered for each perioperative item. The members in the LMIC group then applied the current evidence and adapted the recommendations for each intervention as well as identifying possible new items relevant to LMIC's. The Grading of Recommendations, Assessment, Development and Evaluation system (GRADE) methodology was used to determine the quality of the published evidence. The strength of the recommendations was based on importance of the problem, quality of evidence, balance between desirable and undesirable effects, acceptability to key stakeholders, cost of implementation and specifically the feasibility of implementing in LMIC's and determined through discussions and consensus.\n\nIn addition to previously described ERAS\u00ae Society interventions, the following items were included, revised or discussed: the Surgical Safety Checklist (SSC), preoperative routine human immunodeficiency virus (HIV) testing in countries with a high prevalence of HIV/AIDS (CD4 and viral load for those patients that are HIV positive), delirium screening and prevention, COVID 19 screening, VTE prophylaxis, immuno-nutrition, prehabilitation, minimally invasive surgery (MIS) and a standardized postoperative monitoring guideline.\n\nThese guidelines are seen as a starting point to address the urgent need to improve perioperative care and to effect data-driven, evidence-based care in LMIC's.", "doi": "10.1007/s00268-022-06587-w", "pmid": "35641574", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00268-022-06587-w"}], "notes": [], "created": "2022-06-21T17:36:07.435Z", "modified": "2022-06-21T17:36:07.451Z"}, {"entity": "publication", "iuid": "07dd3b7e73b048b29dc9036d4ed4561b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07dd3b7e73b048b29dc9036d4ed4561b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07dd3b7e73b048b29dc9036d4ed4561b"}}, "title": "Critical Care Nurses' Experiences Caring for Patients When Relatives Were not Allowed in the ICUs due to COVID-19 Pandemic.", "authors": [{"family": "Stenman", "given": "Lina", "initials": "L"}, {"family": "H\u00f6gberg", "given": "Lisa", "initials": "L"}, {"family": "Engstr\u00f6m", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0001-6244-6401", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f93844031da44a79bc89f3d73da4477f.json"}}], "type": "journal article", "published": "2022-05-31", "journal": {"title": "SAGE Open Nurs", "issn": "2377-9608", "volume": "8", "pages": "23779608221103627", "issn-l": null}, "abstract": "Health care workers faced new challenges during the COVID-19 pandemic when physical contact with relatives more or less disappeared.\n\nThe aim of this study is to describe the experiences of critical care nurses (CCNs) working in intensive care units (ICUs) under the visiting restrictions imposed as a result of COVID-19.\n\nThis study followed a qualitative design. The purposive sample included CCNs with at least 1 year of experience working in an ICU with a visiting policy affected by the pandemic. Data collection was carried out via semi-structured interviews and analyzed through a qualitative content analysis with an inductive approach.\n\nThe study results are presented in three categories with 10 subcategories. CCNs value the presence of patients' relatives at the bedside and described many challenges when relatives could not be present with the patient during the pandemic.\n\nClose relatives are able to share essential information about the patients and provide much-needed emotional support to them, the relatives' role is of central importance and CCNs value their presence in ICUs more than any positive consequences of them not being there.", "doi": "10.1177/23779608221103627", "pmid": "35669888", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1177_23779608221103627"}, {"db": "pmc", "key": "PMC9163743"}], "notes": [], "created": "2022-06-20T19:32:37.982Z", "modified": "2022-06-20T19:32:38.037Z"}, {"entity": "publication", "iuid": "d264d65d67174ddabfb94234c528049b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d264d65d67174ddabfb94234c528049b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d264d65d67174ddabfb94234c528049b"}}, "title": "An analysis of how health systems integrated priority-setting in the pandemic planning in a sample of Latin America and the Caribbean countries.", "authors": [{"family": "V\u00e9lez", "given": "Claudia-Marcela", "initials": "CM"}, {"family": "Aguilera", "given": "Bernardo", "initials": "B"}, {"family": "Kapiriri", "given": "Lydia", "initials": "L", "orcid": "0000-0002-1237-6369", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec392c3ae33d40f096e713eaa6a2be11.json"}}, {"family": "Essue", "given": "Beverley M", "initials": "BM"}, {"family": "Nouvet", "given": "Elysee", "initials": "E"}, {"family": "Sandman", "given": "Lars", "initials": "L"}, {"family": "Williams", "given": "Iestyn", "initials": "I"}], "type": "journal article", "published": "2022-05-31", "journal": {"title": "Health Res Policy Syst", "issn": "1478-4505", "volume": "20", "issue": "1", "pages": "58", "issn-l": null}, "abstract": "Latin America and the Caribbean (LAC) are among those regions most affected by the COVID-19 pandemic worldwide. The COVID-19 pandemic has strained health systems in the region. In this context of severe healthcare resource constraints, there is a need for systematic priority-setting to support decision-making which ensures the best use of resources while considering the needs of the most vulnerable groups. The aim of this paper was to provide a critical description and analysis of how health systems considered priority-setting in the COVID-19 response and preparedness plans of a sample of 14 LAC countries; and to identify the associated research gaps.\n\nA documentary analysis of COVID-19 preparedness and response plans was performed in a sample of 14 countries in the LAC region. We assessed the degree to which the documented priority-setting processes adhered to established quality indicators of effective priority-setting included in the Kapiriri and Martin framework. We conducted a descriptive analysis of the degree to which the reports addressed the quality parameters for each individual country, as well as a cross-country comparison to explore whether parameters varied according to independent variables.\n\nWhile all plans were led and supported by the national governments, most included only a limited number of quality indicators for effective priority-setting. There was no systematic pattern between the number of quality indicators and the country's health system and political contexts; however, the countries that had the least number of quality indicators tended to be economically disadvantaged.\n\nThis study adds to the literature by providing the first descriptive analysis of the inclusion of priority-setting during a pandemic, using the case of COVID-19 response and preparedness plans in the LAC region. The analysis found that despite the strong evidence of political will and stakeholder participation, none of the plans presented a clear priority-setting process, or used a formal priority-setting framework, to define interventions, populations, geographical regions, healthcare setting or resources prioritized. There is need for case studies that analyse how priority-setting actually occurred during the COVID-19 pandemic and the degree to which the implementation reflected the plans and the parameters of effective priority-setting, as well as the impact of the prioritization processes on population health, with a focus on the most vulnerable groups.", "doi": "10.1186/s12961-022-00861-y", "pmid": "35642055", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12961-022-00861-y"}], "notes": [], "created": "2022-06-21T17:35:46.517Z", "modified": "2022-06-21T17:35:46.600Z"}, {"entity": "publication", "iuid": "6cc5cac975e84955a775563b5c242bf0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6cc5cac975e84955a775563b5c242bf0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6cc5cac975e84955a775563b5c242bf0"}}, "title": "Quality of life (QoL) among COVID-19 recovered healthcare workers in Bangladesh.", "authors": [{"family": "Rashid", "given": "Md Utba", "initials": "MU"}, {"family": "Khan", "given": "Md Abdullah Saeed", "initials": "MAS"}, {"family": "Dalal", "given": "Koustuv", "initials": "K", "orcid": "0000-0001-7393-796X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab5e44a17b7545988cb46cdf5b1f3e4e.json"}}, {"family": "Sagar", "given": "Soumik Kha", "initials": "SK"}, {"family": "Hossian", "given": "Mosharop", "initials": "M"}, {"family": "Barsha", "given": "Sabrina Yesmin", "initials": "SY"}, {"family": "Haque", "given": "Miah Md Akiful", "initials": "MMA"}, {"family": "Ali Hossain", "given": "Mohammad", "initials": "M"}, {"family": "Hayatun Nabi", "given": "Mohammad", "initials": "M"}, {"family": "Hawlader", "given": "Mohammad Delwer Hossain", "initials": "MDH"}], "type": "journal article", "published": "2022-05-30", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "volume": "22", "issue": "1", "pages": "716", "issn-l": null}, "abstract": "The Coronavirus Disease 2019 (COVID-19) caused by the SARS-CoV-2 virus has taken the lives of more than 100,000 healthcare workers (HCWs) so far. Those who survived continuously work under immense physical and psychological pressure, and their quality of life (QoL) is impacted. The study aimed to assess the QoL among HCWs in Bangladesh who recovered from COVID-19.\n\nThis cross-sectional, telephonic interview-based study was conducted among 322 randomly selected HCWs from Bangladesh who were positive for COVID-19 and recovered from the infection before the interview. Data were collected from June to November 2020. We examined the impact of COVID on the QoL of the participants using the validated Bangladesh version of the World Health Organization (WHO) Quality of life questionnaire brief (WHOQOL-BREF). All analyses were done by STATA (Version 16.1).\n\nMore than half of the health care professionals were male (56.0%), aged between 26-35 years (51%), and completed graduation (49%). The majority of the study participants in the four domains were married (n = 263, 81%) and living in Dhaka. The average score of the participants was 70.91 \u00b1 13.07, 62.68 \u00b1 14.99, 66.93 \u00b1 15.14, and 63.56 \u00b1 12.11 in physical, psychological, social relationship and environmental domains, respectively. HCWs in urban areas enjoyed 2.4 times better socially stable lives (OR: 2.42, 95% CI: 1.18-4.96) but 72% less psychologically satisfactory lives.\n\nHCWs' post-COVID quality of life depended on variable interaction of demographic socioeconomic, including old age, female sex, graduation, and higher monthly income. The findings indicate the issues which should be addressed to improve the quality of life of frontline workers who fight against the pandemic.", "doi": "10.1186/s12913-022-07961-z", "pmid": "35637475", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-022-07961-z"}], "notes": [], "created": "2022-06-21T17:36:57.103Z", "modified": "2022-06-21T17:37:33.850Z"}, {"entity": "publication", "iuid": "5e658bf185dd46ceaf587101889e1b73", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e658bf185dd46ceaf587101889e1b73.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e658bf185dd46ceaf587101889e1b73"}}, "title": "Pre-exascale HPC approaches for molecular dynamics simulations. Covid-19 research: A use case.", "authors": [{"family": "Wiecz\u00f3r", "given": "Mi\u0142osz", "initials": "M"}, {"family": "Genna", "given": "Vito", "initials": "V"}, {"family": "Aranda", "given": "Juan", "initials": "J"}, {"family": "Badia", "given": "Rosa M", "initials": "RM", "orcid": "0000-0003-2941-5499", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/118643637250473c831a71d4229a94b4.json"}}, {"family": "Gelp\u00ed", "given": "Josep Llu\u00eds", "initials": "JL"}, {"family": "Gapsys", "given": "Vytautas", "initials": "V", "orcid": "0000-0002-6761-7780", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f09aac84213f4745a30d5aa4b21d39a0.json"}}, {"family": "de Groot", "given": "Bert L", "initials": "BL"}, {"family": "Lindahl", "given": "Erik", "initials": "E"}, {"family": "Municoy", "given": "Mart\u00ed", "initials": "M", "orcid": "0000-0003-4399-153X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822616e19cea40f4a71d758873555eb6.json"}}, {"family": "Hospital", "given": "Adam", "initials": "A"}, {"family": "Orozco", "given": "Modesto", "initials": "M", "orcid": "0000-0002-8608-3278", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d51c4e79f3a4b6f90868149ffbf7daa.json"}}], "type": "journal article", "published": "2022-05-30", "journal": {"title": "Wiley Interdiscip Rev Comput Mol Sci", "issn": "1759-0876", "pages": "e1622", "issn-l": null}, "abstract": "Exascale computing has been a dream for ages and is close to becoming a reality that will impact how molecular simulations are being performed, as well as the quantity and quality of the information derived for them. We review how the biomolecular simulations field is anticipating these new architectures, making emphasis on recent work from groups in the BioExcel Center of Excellence for High Performance Computing. We exemplified the power of these simulation strategies with the work done by the HPC simulation community to fight Covid-19 pandemics. This article is categorized under:Data Science > Computer Algorithms and ProgrammingData Science > Databases and Expert SystemsMolecular and Statistical Mechanics > Molecular Dynamics and Monte-Carlo Methods.", "doi": "10.1002/wcms.1622", "pmid": "35935573", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "WCMS1622"}, {"db": "pmc", "key": "PMC9347456"}], "notes": [], "created": "2022-08-11T11:53:30.133Z", "modified": "2022-08-11T11:53:48.319Z"}, {"entity": "publication", "iuid": "9af1ae25bf344ecf94993e1aa5dab071", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9af1ae25bf344ecf94993e1aa5dab071.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9af1ae25bf344ecf94993e1aa5dab071"}}, "title": "The significance of surface neutrophilic MPO expression level in NETosis and NETosis-associated coagulopathies in covid-19 infected patients.", "authors": [{"family": "Jamali", "given": "Elham", "initials": "E"}, {"family": "Abbasi", "given": "Mojdeh", "initials": "M"}, {"family": "Tayer", "given": "Akbar Hashemi", "initials": "AH"}, {"family": "Monfared", "given": "Ali Arabi", "initials": "AA"}, {"family": "Tandel", "given": "Parisa", "initials": "P"}, {"family": "Tamaddon", "given": "Gholamhossein", "initials": "G"}, {"family": "Kazerooni", "given": "Ehsan Sarraf", "initials": "ES"}, {"family": "Rakhshandehroo", "given": "Shahrokh", "initials": "S"}, {"family": "Ranjbaran", "given": "Reza", "initials": "R"}], "type": "journal article", "published": "2022-05-29", "journal": {"title": "Blood Cells Mol Dis", "issn": "1096-0961", "volume": "96", "pages": "102676", "issn-l": null}, "abstract": "Inflammatory response-induced coagulopathy is a common complication associated with severe form of covid-19 infection. Evidences suggest that neutrophil extracellular traps (NETs) play a significant role in triggering the immunothrombosis in this condition. We aimed to evaluate the diagnostic value of surface neutrophilic myeloperoxidase (MPO) as NETosis biomarker for predicting the risk of covid-19-associated coagulopathies.\n\nCovid-19 infection was assessed by real-time-PCR and plasma d-dimer levels were measured by ELFA. Based on the covid-19 infection and d-dimer level outcomes, patients were categorized into four groups. Any alteration in the serum level of IL-6, H3Cit and neutrophilic surface MPO were analyzed by CLIA, ELISA, and flow cytometry, respectively.\n\nH3Cit variations and different d-dimer values confirmed the association between NETosis and coagulopathies. Findings showed that the expression of neutrophilic MPO reduced in cases with NETosis, which was correlated with increased levels of H3Cit. ANC/MPO ratio was signified as a valuable marker to discriminate the covid-19 and non covid-19-associated coagulopathies and could be considered as a prognostic factor due to its noteworthy correlation with serum IL-6 concentration.\n\nDeclined levels of surface neutrophilic MPO in NETosis correlate with covid-19-associated coagulopathies and increased IL-6 levels, as a potential biomarker of covid-19 disease severity.", "doi": "10.1016/j.bcmd.2022.102676", "pmid": "35661911", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1079-9796(22)00033-X"}], "notes": [], "created": "2022-06-21T17:16:55.067Z", "modified": "2022-06-21T17:16:55.097Z"}, {"entity": "publication", "iuid": "a96ded4eb17e4db38a262e53b6c1976c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a96ded4eb17e4db38a262e53b6c1976c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a96ded4eb17e4db38a262e53b6c1976c"}}, "title": "Transforming or tinkering: the world remains unprepared for the next pandemic threat.", "authors": [{"family": "Clark", "given": "Helen", "initials": "H"}, {"family": "C\u00e1rdenas", "given": "Mauricio", "initials": "M"}, {"family": "Dybul", "given": "Mark", "initials": "M"}, {"family": "Kazatchkine", "given": "Michel", "initials": "M"}, {"family": "Liu", "given": "Joanne", "initials": "J"}, {"family": "Miliband", "given": "David", "initials": "D"}, {"family": "Nordstr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Sudan", "given": "Preeti", "initials": "P"}, {"family": "Zedillo", "given": "Ernesto", "initials": "E"}, {"family": "Obaid", "given": "Thoraya", "initials": "T"}, {"family": "McCarney", "given": "Rosemary", "initials": "R"}, {"family": "Radin", "given": "Elizabeth", "initials": "E"}, {"family": "Eliasz", "given": "Mike Kalmus", "initials": "MK"}, {"family": "McNab", "given": "Christine", "initials": "C"}, {"family": "Legido-Quigley", "given": "Helena", "initials": "H"}, {"family": "Sirleaf", "given": "Ellen Johnson", "initials": "EJ"}], "type": "journal article", "published": "2022-05-28", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "399", "issue": "10340", "pages": "1995-1999", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(22)00929-1", "pmid": "35597246", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(22)00929-1"}, {"db": "pmc", "key": "PMC9114832"}], "notes": [], "created": "2022-06-21T17:58:47.542Z", "modified": "2022-06-21T17:59:16.940Z"}, {"entity": "publication", "iuid": "3232d2ae3e22401c8cbac0ff88028687", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3232d2ae3e22401c8cbac0ff88028687.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3232d2ae3e22401c8cbac0ff88028687"}}, "title": "Battling extraordinary situations and conflicting emotions-A qualitative study of being a newly graduated Registered Nurse in the emergency department during the COVID-19 pandemic.", "authors": [{"family": "Carnesten", "given": "Hillewi", "initials": "H", "orcid": "0000-0002-6512-849X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6fb875140b7345fa9e94862b866e066c.json"}}, {"family": "Wiklund Gustin", "given": "Lena", "initials": "L", "orcid": "0000-0002-9714-577X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8bcbede9d577497495130e22dd6a6c88.json"}}, {"family": "Skoglund", "given": "Karin", "initials": "K", "orcid": "0000-0001-8008-8169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e6fc2925ce9443e865e3dc39411af54.json"}}, {"family": "Von Heideken W\u00e5gert", "given": "Petra", "initials": "P", "orcid": "0000-0001-6292-7010", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4d6dfb26a37419385eb8e257f89d950.json"}}], "type": "journal article", "published": "2022-05-28", "journal": {"title": "Nurs Open", "issn": "2054-1058", "issn-l": null}, "abstract": "To describe newly graduated registered nurses' (NGRNs') experiences of encountering stress in emergency departments (EDs) during the COVID-19 pandemic.\n\nA qualitative descriptive study.\n\nData from 14 in-depth interviews with NGRNs working in an ED for 3-36 months after graduation was analysed by the means of qualitative content analysis as described by Graneheim and Lundman. Interviews were conducted from March to November 2020 covering the first two waves of the pandemic.\n\nData revealed three categories and nine subcategories comprised in the theme Battling extraordinary situations and conflicting emotions. Empowered by acknowledging themselves as important caregivers during the pandemic NGRNs struggle against limitations and exert themselves beyond their known limit. External stressors due to work overload in combination with understaffing force NGRNs into the role of the experienced nurse prematurely and internal stressors derives from part taking in less qualitative care.", "doi": "10.1002/nop2.1250", "pmid": "35633153", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T17:39:20.222Z", "modified": "2022-06-21T17:39:20.361Z"}, {"entity": "publication", "iuid": "1c4f45fce1454dd9a3156ad81c103970", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1c4f45fce1454dd9a3156ad81c103970.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1c4f45fce1454dd9a3156ad81c103970"}}, "title": "Time Trend in SARS-CoV-2 Seropositivity, Surveillance Detection- and Infection Fatality Ratio until Spring 2021 in the Tirschenreuth County-Results from a Population-Based Longitudinal Study in Germany.", "authors": [{"family": "Einhauser", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-4177-4451", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0d657959e714aa18b8cda14ae8b260d.json"}}, {"family": "Peterhoff", "given": "David", "initials": "D", "orcid": "0000-0001-5911-6233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3784a38e6f81455e9af931fae1c0b830.json"}}, {"family": "Beileke", "given": "Stephanie", "initials": "S"}, {"family": "G\u00fcnther", "given": "Felix", "initials": "F", "orcid": "0000-0001-6582-1174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b533ef33e9a4769b5ba32a0e616f5c0.json"}}, {"family": "Niller", "given": "Hans-Helmut", "initials": "HH"}, {"family": "Steininger", "given": "Philipp", "initials": "P"}, {"family": "Kn\u00f6ll", "given": "Antje", "initials": "A"}, {"family": "Korn", "given": "Klaus", "initials": "K", "orcid": "0000-0003-1891-2107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a90fec0b05a4968b6ac28e9c4b675d8.json"}}, {"family": "Berr", "given": "Melanie", "initials": "M"}, {"family": "Sch\u00fctz", "given": "Anja", "initials": "A"}, {"family": "Wiegrebe", "given": "Simon", "initials": "S"}, {"family": "Stark", "given": "Klaus J", "initials": "KJ"}, {"family": "Gessner", "given": "Andr\u00e9", "initials": "A"}, {"family": "Burkhardt", "given": "Ralph", "initials": "R", "orcid": "0000-0003-1924-1202", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4eb3b61804944e6a065c85267832d8a.json"}}, {"family": "Kabesch", "given": "Michael", "initials": "M"}, {"family": "Schedl", "given": "Holger", "initials": "H"}, {"family": "K\u00fcchenhoff", "given": "Helmut", "initials": "H"}, {"family": "Pfahlberg", "given": "Annette B", "initials": "AB", "orcid": "0000-0002-2234-1215", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5c6a8a551ed4d9e9f51afe633b3080c.json"}}, {"family": "Heid", "given": "Iris M", "initials": "IM"}, {"family": "Gefeller", "given": "Olaf", "initials": "O", "orcid": "0000-0002-8985-7582", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15905044556b4978bca8b0728c901348.json"}}, {"family": "\u00dcberla", "given": "Klaus", "initials": "K", "orcid": "0000-0001-7822-3835", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/221ba6c8276a405380303915261e3558.json"}}, {"family": "Wagner", "given": "Ralf", "initials": "R"}], "type": "journal article", "published": "2022-05-27", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "6", "issn-l": "1999-4915"}, "abstract": "Herein, we provide results from a prospective population-based longitudinal follow-up (FU) SARS-CoV-2 serosurveillance study in Tirschenreuth, the county which was hit hardest in Germany in spring 2020 and early 2021. Of 4203 individuals aged 14 years or older enrolled at baseline (BL, June 2020), 3546 participated at FU1 (November 2020) and 3391 at FU2 (April 2021). Key metrics comprising standardized seroprevalence, surveillance detection ratio (SDR), infection fatality ratio (IFR) and success of the vaccination campaign were derived using the Roche N- and S-Elecsys anti-SARS-CoV-2 test together with a self-administered questionnaire. N-seropositivity at BL was 9.2% (1st wave). While we observed a low new seropositivity between BL and FU1 (0.9%), the combined 2nd and 3rd wave accounted for 6.1% new N-seropositives between FU1 and FU2 (ever seropositives at FU2: 15.4%). The SDR decreased from 5.4 (BL) to 1.1 (FU2) highlighting the success of massively increased testing in the population. The IFR based on a combination of serology and registration data resulted in 3.3% between November 2020 and April 2021 compared to 2.3% until June 2020. Although IFRs were consistently higher at FU2 compared to BL across age-groups, highest among individuals aged 70+ (18.3% versus 10.7%, respectively), observed differences were within statistical uncertainty bounds. While municipalities with senior care homes showed a higher IFR at BL (3.0% with senior care home vs. 0.7% w/o), this effect diminished at FU2 (3.4% vs. 2.9%). In April 2021 (FU2), vaccination rate in the elderly was high (&gt;77.4%, age-group 80+).", "doi": "10.3390/v14061168", "pmid": "35746640", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "v14061168"}, {"db": "pmc", "key": "PMC9228731"}], "notes": [], "created": "2022-08-19T05:42:07.176Z", "modified": "2022-08-19T05:42:28.995Z"}, {"entity": "publication", "iuid": "82358c5f8f5d41f385b21a78b1c1cc94", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82358c5f8f5d41f385b21a78b1c1cc94.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82358c5f8f5d41f385b21a78b1c1cc94"}}, "title": "Resilience and post-traumatic growth in the transition to motherhood during the COVID-19 pandemic: A qualitative exploratory study.", "authors": [{"family": "Thomson", "given": "Gill", "initials": "G", "orcid": "0000-0003-3392-8182", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01ec0dfaaa56415eb9121e6451021640.json"}}, {"family": "Cook", "given": "Julie", "initials": "J"}, {"family": "Nowland", "given": "Rebecca", "initials": "R"}, {"family": "Donnellan", "given": "Warren James", "initials": "WJ", "orcid": "0000-0002-0224-9155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32764a489b614baeb20ac6ae07593a85.json"}}, {"family": "Topalidou", "given": "Anastasia", "initials": "A"}, {"family": "Jackson", "given": "Leanne", "initials": "L"}, {"family": "Fallon", "given": "Vicky", "initials": "V"}], "type": "journal article", "published": "2022-05-27", "journal": {"title": "Scand J Caring Sci", "issn": "1471-6712", "issn-l": null}, "abstract": "Most perinatal research relating to COVID-19 focuses on its negative impact on maternal and parental mental health. Currently, there are limited data on how to optimise positive health during the pandemic. We aimed to bridge this knowledge gap by exploring how women have adapted to becoming a new parent during the pandemic and to identify elements of resilience and growth within their narratives. Mothers of infants under the age of 4 months were recruited as part of a wider UK mixed-methods study. Semi-structured interviews with 20 mothers elicited data about how COVID-19 had influenced their transition to parent a new infant, and if and how they adapted during the pandemic, what strategies they used, and if and how these had been effective. Directed qualitative content analysis was undertaken, and pre-existing theoretical frameworks of resilience and post-traumatic growth (PTG) were used to analyse and interpret the data set. The findings show evidence of a range of resilience and PTG concepts experienced during the pandemic in this cohort. Salient resilience themes included personal (active coping, reflective functioning, and meaning-making), relational (social support, partner relationships, and family relationships), and contextual (health and social connectedness) factors. There was also evidence of PTG in terms of the potential for new work-related and leisure opportunities, and women developing wider and more meaningful connections with others. Although further research is needed, and with individuals from diverse socioeconomic backgrounds, these findings emphasise the significance of social support and connectivity as vital to positive mental health. Opportunities to increase digital innovations to connect and support new parents should be maximised to buffer the negative impacts of further social distancing and crisis situations.", "doi": "10.1111/scs.13087", "pmid": "35621069", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2022-06-21T17:45:42.061Z", "modified": "2022-06-21T17:46:19.515Z"}, {"entity": "publication", "iuid": "08da99ee2ab34869aa7cc6201fbf2cda", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/08da99ee2ab34869aa7cc6201fbf2cda.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/08da99ee2ab34869aa7cc6201fbf2cda"}}, "title": "Determination of IgG1 and IgG3 SARS-CoV-2 Spike Protein and Nucleocapsid Binding-Who Is Binding Who and Why?", "authors": [{"family": "Iles", "given": "Jason K", "initials": "JK"}, {"family": "Zmuidinaite", "given": "Raminta", "initials": "R", "orcid": "0000-0001-7728-6623", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/421ae7d6575445888ac6bb7f537b4b16.json"}}, {"family": "Sadee", "given": "Christoph", "initials": "C"}, {"family": "Gardiner", "given": "Anna", "initials": "A"}, {"family": "Lacey", "given": "Jonathan", "initials": "J"}, {"family": "Harding", "given": "Stephen", "initials": "S"}, {"family": "Wallis", "given": "Gregg", "initials": "G"}, {"family": "Patel", "given": "Roshani", "initials": "R"}, {"family": "Roblett", "given": "Debra", "initials": "D"}, {"family": "Heeney", "given": "Jonathan", "initials": "J"}, {"family": "Baxendale", "given": "Helen", "initials": "H"}, {"family": "Iles", "given": "Ray Kruse", "initials": "RK"}], "type": "journal article", "published": "2022-05-27", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "23", "issue": "11", "pages": "6050", "issn-l": null}, "abstract": "The involvement of immunoglobulin (Ig) G3 in the humoral immune response to SARS-CoV-2 infection has been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS) in COVID-19. The exact molecular mechanism is unknown, but it is thought to involve this IgG subtype's differential ability to fix, complement and stimulate cytokine release. We examined the binding of convalescent patient antibodies to immobilized nucleocapsids and spike proteins by matrix-assisted laser desorption/ionization-time of flight (MALDI-ToF) mass spectrometry. IgG3 was a major immunoglobulin found in all samples. Differential analysis of the spectral signatures found for the nucleocapsid versus the spike protein demonstrated that the predominant humoral immune response to the nucleocapsid was IgG3, whilst for the spike protein it was IgG1. However, the spike protein displayed a strong affinity for IgG3 itself, as it would bind from control plasma samples, as well as from those previously infected with SARS-CoV-2, similar to the way protein G binds IgG1. Furthermore, detailed spectral analysis indicated that a mass shift consistent with hyper-glycosylation or glycation was a characteristic of the IgG3 captured by the spike protein.", "doi": "10.3390/ijms23116050", "pmid": "35682724", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9181569"}, {"db": "pii", "key": "ijms23116050"}], "notes": [], "created": "2022-06-20T19:26:26.231Z", "modified": "2023-06-19T14:54:05.767Z"}, {"entity": "publication", "iuid": "3aa502c25f0c4b22b6f27b6881488e53", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3aa502c25f0c4b22b6f27b6881488e53.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3aa502c25f0c4b22b6f27b6881488e53"}}, "title": "Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity.", "authors": [{"family": "Batlle", "given": "Daniel", "initials": "D"}, {"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Garreta", "given": "Elena", "initials": "E"}, {"family": "Hassler", "given": "Luise", "initials": "L"}, {"family": "Wysocki", "given": "Jan", "initials": "J"}, {"family": "Chandar", "given": "Vasuretha", "initials": "V"}, {"family": "Schwartz", "given": "Robert E", "initials": "RE"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Montserrat", "given": "Nuria", "initials": "N"}, {"family": "Bader", "given": "Michael", "initials": "M"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}], "type": "letter", "published": "2022-05-26", "journal": {"title": "Cell", "issn": "1097-4172", "volume": "185", "issue": "11", "pages": "1837-1839", "issn-l": "0092-8674"}, "abstract": null, "doi": "10.1016/j.cell.2022.05.004", "pmid": "35623327", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0092-8674(22)00588-8"}], "notes": [], "created": "2022-06-21T17:44:41.930Z", "modified": "2022-06-21T17:44:41.944Z"}, {"entity": "publication", "iuid": "0e400cb9bc494d649666d89f4e9b636b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e400cb9bc494d649666d89f4e9b636b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e400cb9bc494d649666d89f4e9b636b"}}, "title": "Editorial: Platelet Function in COVID-19.", "authors": [{"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A"}, {"family": "Sand\u00e9n", "given": "Per", "initials": "P"}, {"family": "Mitroulis", "given": "Ioannis", "initials": "I"}, {"family": "van der Meijden", "given": "Paola E J", "initials": "PEJ"}], "type": "editorial", "published": "2022-05-26", "journal": {"title": "Front Cardiovasc Med", "issn": "2297-055X", "volume": "9", "pages": "912472", "issn-l": null}, "abstract": null, "doi": "10.3389/fcvm.2022.912472", "pmid": "35722094", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC9204630"}], "notes": [], "created": "2022-08-17T12:46:16.941Z", "modified": "2022-08-17T12:46:16.954Z"}, {"entity": "publication", "iuid": "7243b81f939c47b88b5e8e0ce022db0a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7243b81f939c47b88b5e8e0ce022db0a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7243b81f939c47b88b5e8e0ce022db0a"}}, "title": "Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction.", "authors": [{"family": "Guimond", "given": "Scott E", "initials": "SE"}, {"family": "Mycroft-West", "given": "Courtney J", "initials": "CJ"}, {"family": "Gandhi", "given": "Neha S", "initials": "NS", "orcid": "0000-0003-3119-6731", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78db66b38cb24a759aaed5fd1a7246e6.json"}}, {"family": "Tree", "given": "Julia A", "initials": "JA"}, {"family": "Le", "given": "Thuy T", "initials": "TT"}, {"family": "Spalluto", "given": "C Mirella", "initials": "CM"}, {"family": "Humbert", "given": "Maria V", "initials": "MV"}, {"family": "Buttigieg", "given": "Karen R", "initials": "KR"}, {"family": "Coombes", "given": "Naomi", "initials": "N"}, {"family": "Elmore", "given": "Michael J", "initials": "MJ"}, {"family": "Wand", "given": "Matthew", "initials": "M"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Said", "given": "Joanna", "initials": "J"}, {"family": "Setoh", "given": "Yin Xiang", "initials": "YX"}, {"family": "Amarilla", "given": "Alberto A", "initials": "AA"}, {"family": "Modhiran", "given": "Naphak", "initials": "N"}, {"family": "Sng", "given": "Julian D J", "initials": "JDJ"}, {"family": "Chhabra", "given": "Mohit", "initials": "M"}, {"family": "Young", "given": "Paul R", "initials": "PR"}, {"family": "Rawle", "given": "Daniel J", "initials": "DJ"}, {"family": "Lima", "given": "Marcelo A", "initials": "MA"}, {"family": "Yates", "given": "Edwin A", "initials": "EA", "orcid": "0000-0001-9365-5433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/16a88f385653436bb561e77ffc4fd73a.json"}}, {"family": "Karlsson", "given": "Richard", "initials": "R"}, {"family": "Miller", "given": "Rebecca L", "initials": "RL", "orcid": "0000-0001-8574-1948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8aae63723f184b4791e0b61f55d023fc.json"}}, {"family": "Chen", "given": "Yen-Hsi", "initials": "YH"}, {"family": "Bagdonaite", "given": "Ieva", "initials": "I", "orcid": "0000-0002-9383-8448", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5981026aabfd475787f9a79a2ea7340f.json"}}, {"family": "Yang", "given": "Zhang", "initials": "Z"}, {"family": "Stewart", "given": "James", "initials": "J"}, {"family": "Nguyen", "given": "Dung", "initials": "D"}, {"family": "Laidlaw", "given": "Stephen", "initials": "S"}, {"family": "Hammond", "given": "Edward", "initials": "E"}, {"family": "Dredge", "given": "Keith", "initials": "K"}, {"family": "Wilkinson", "given": "Tom M A", "initials": "TMA"}, {"family": "Watterson", "given": "Daniel", "initials": "D"}, {"family": "Khromykh", "given": "Alexander A", "initials": "AA"}, {"family": "Suhrbier", "given": "Andreas", "initials": "A"}, {"family": "Carroll", "given": "Miles W", "initials": "MW"}, {"family": "Trybala", "given": "Edward", "initials": "E"}, {"family": "Bergstr\u00f6m", "given": "Tomas", "initials": "T"}, {"family": "Ferro", "given": "Vito", "initials": "V", "orcid": "0000-0003-3306-2550", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/059cdf96e0114bb4ab46289d10956055.json"}}, {"family": "Skidmore", "given": "Mark A", "initials": "MA"}, {"family": "Turnbull", "given": "Jeremy E", "initials": "JE", "orcid": "0000-0002-1791-754X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/066f42660595487e817530f8888ee45a.json"}}], "type": "journal article", "published": "2022-05-25", "journal": {"title": "ACS Cent Sci", "issn": "2374-7943", "volume": "8", "issue": "5", "pages": "527-545", "issn-l": null}, "abstract": "Heparan sulfate (HS) is a cell surface polysaccharide recently identified as a coreceptor with the ACE2 protein for the S1 spike protein on SARS-CoV-2 virus, providing a tractable new therapeutic target. Clinically used heparins demonstrate an inhibitory activity but have an anticoagulant activity and are supply-limited, necessitating alternative solutions. Here, we show that synthetic HS mimetic pixatimod (PG545), a cancer drug candidate, binds and destabilizes the SARS-CoV-2 spike protein receptor binding domain and directly inhibits its binding to ACE2, consistent with molecular modeling identification of multiple molecular contacts and overlapping pixatimod and ACE2 binding sites. Assays with multiple clinical isolates of SARS-CoV-2 virus show that pixatimod potently inhibits the infection of monkey Vero E6 cells and physiologically relevant human bronchial epithelial cells at safe therapeutic concentrations. Pixatimod also retained broad potency against variants of concern (VOC) including B.1.1.7 (Alpha), B.1.351 (Beta), B.1.617.2 (Delta), and B.1.1.529 (Omicron). Furthermore, in a K18-hACE2 mouse model, pixatimod significantly reduced SARS-CoV-2 viral titers in the upper respiratory tract and virus-induced weight loss. This demonstration of potent anti-SARS-CoV-2 activity tolerant to emerging mutations establishes proof-of-concept for targeting the HS-Spike protein-ACE2 axis with synthetic HS mimetics and provides a strong rationale for clinical investigation of pixatimod as a potential multimodal therapeutic for COVID-19.", "doi": "10.1021/acscentsci.1c01293", "pmid": "35647275", "labels": {"Category: Biochemistry": null, "Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9136977"}], "notes": [], "created": "2022-06-21T17:31:54.664Z", "modified": "2023-06-19T14:56:08.925Z"}, {"entity": "publication", "iuid": "456dc8ed53b644328aedc39158d52624", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/456dc8ed53b644328aedc39158d52624.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/456dc8ed53b644328aedc39158d52624"}}, "title": "Prior-aware autoencoders for lung pathology segmentation.", "authors": [{"family": "Astaraki", "given": "Mehdi", "initials": "M"}, {"family": "Smedby", "given": "\u00d6rjan", "initials": "\u00d6"}, {"family": "Wang", "given": "Chunliang", "initials": "C"}], "type": "journal article", "published": "2022-05-25", "journal": {"title": "Med Image Anal", "issn": "1361-8423", "volume": "80", "pages": "102491", "issn-l": null}, "abstract": "Segmentation of lung pathology in Computed Tomography (CT) images is of great importance for lung disease screening. However, the presence of different types of lung pathologies with a wide range of heterogeneities in size, shape, location, and texture, on one side, and their visual similarity with respect to surrounding tissues, on the other side, make it challenging to perform reliable automatic lesion segmentation. To leverage segmentation performance, we propose a deep learning framework comprising a Normal Appearance Autoencoder (NAA) model to learn the distribution of healthy lung regions and reconstruct pathology-free images from the corresponding pathological inputs by replacing the pathological regions with the characteristics of healthy tissues. Detected regions that represent prior information regarding the shape and location of pathologies are then integrated into a segmentation network to guide the attention of the model into more meaningful delineations. The proposed pipeline was tested on three types of lung pathologies, including pulmonary nodules, Non-Small Cell Lung Cancer (NSCLC), and Covid-19 lesion on five comprehensive datasets. The results show the superiority of the proposed prior model, which outperformed the baseline segmentation models in all the cases with significant margins. On average, adding the prior model improved the Dice coefficient for the segmentation of lung nodules by 0.038, NSCLCs by 0.101, and Covid-19 lesions by 0.041. We conclude that the proposed NAA model produces reliable prior knowledge regarding the lung pathologies, and integrating such knowledge into a prior segmentation network leads to more accurate delineations.", "doi": "10.1016/j.media.2022.102491", "pmid": "35653902", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1361-8415(22)00138-4"}], "notes": [], "created": "2022-06-21T17:21:31.741Z", "modified": "2022-06-21T17:21:46.880Z"}, {"entity": "publication", "iuid": "754359aeb3274887b4ed42654c5cb5a7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/754359aeb3274887b4ed42654c5cb5a7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/754359aeb3274887b4ed42654c5cb5a7"}}, "title": "COVID-19 seroprevalence and clinical picture in Swedish pediatric oncology and hematology patients.", "authors": [{"family": "Sundberg", "given": "Emil", "initials": "E", "orcid": "0000-0001-5087-1400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62ac6304201e4ec181ea55bcadd16b0d.json"}}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Nilsson", "given": "Anna", "initials": "A", "orcid": "0000-0001-5885-7101", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e552225ab82346d1b2d727584683f156.json"}}, {"family": "Pahnke", "given": "Simon", "initials": "S"}, {"family": "Enblad", "given": "Gunilla", "initials": "G"}, {"family": "Kolstad", "given": "Linda", "initials": "L"}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Torkki", "given": "Milla", "initials": "M"}, {"family": "Zhou", "given": "Otto", "initials": "O"}, {"family": "Anderson", "given": "Jenna", "initials": "J"}, {"family": "Harila-Saari", "given": "Arja", "initials": "A", "orcid": "0000-0003-2767-5828", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61332c8f7db64f4e81a61f3b68439025.json"}}, {"family": "Palle", "given": "Josefine", "initials": "J"}], "type": "journal article", "published": "2022-05-25", "journal": {"title": "Pediatr Blood Cancer", "issn": "1545-5017", "pages": "e29773", "issn-l": null}, "abstract": "Children develop symptomatic coronavirus disease 2019 (COVID-19) more rarely than adults upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pediatric oncology and hematology patients may be at increased risk of severe COVID-19 due to their underlying disease or treatment. We investigated COVID-19 and seroprevalence of anti-SARS-CoV-2 antibodies, respectively, in a Swedish cohort of pediatric oncology and hematology patients.\n\nPatients (n = 136) were recruited between June 2020 and September 2021 at Uppsala University Children's Hospital, Sweden. Up to six consecutive blood samples per patient were analyzed for wild-type anti-S1 IgM and IgG antibodies (including after vaccination, n = 4). Clinical data on COVID-19 (including polymerase chain reaction [PCR] test results) were collected from electronic medical records. A questionnaire was completed at recruitment.\n\nA cumulative seroprevalence (IgM and IgG) of 33% (45/136 patients, 95% confidence interval: 25%-41%) was observed in this patient cohort, of whom 66% (90/136 patients) were under severe immunosuppressive treatment during the study period. Increasing patient age (p = .037) and PCR test results (p < .002) were associated with seropositivity in nonvaccinated cases. Most seropositive, nonvaccinated cases (32/43, 74%) were never PCR-verified for SARS-CoV-2 infection. Of the 13 patients with PCR-verified infection, nine (69%) reported mild disease. A majority (63%) reported continued school attendance during the pandemic.\n\nSwedish pediatric oncology and hematology patients developed antibodies against SARS-CoV-2, despite their diagnosis and/or treatment, and the observed seroprevalence was similar to that in national pediatric outpatients. PCR-verified cases underestimate the true incidence of COVID-19 in this patient cohort.", "doi": "10.1002/pbc.29773", "pmid": "35615775", "labels": {"Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Research Area: Pandemic preparedness": null, "Type: Journal article": null, "Category: Health": null, "Research Area: Drug discovery and repurposing of drugs": null}, "xrefs": [], "notes": [], "created": "2022-06-21T17:48:12.392Z", "modified": "2022-06-21T17:49:07.415Z"}, {"entity": "publication", "iuid": "737f9cdb4b82484db6b5c7f3e581bb86", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/737f9cdb4b82484db6b5c7f3e581bb86.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/737f9cdb4b82484db6b5c7f3e581bb86"}}, "title": "Assessing Access to WASH in Urban Schools during COVID-19 in Kazakhstan: Case Study of Central Kazakhstan.", "authors": [{"family": "Toleubekov", "given": "Berik", "initials": "B", "orcid": "0000-0003-2156-5513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de10dab596684ac6b713795af6a862d6.json"}}, {"family": "Bolatova", "given": "Zhanerke", "initials": "Z"}, {"family": "Stafstr\u00f6m", "given": "Martin", "initials": "M", "orcid": "0000-0002-6392-3588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/875e62bf093942a990203d3e4dd20d70.json"}}], "type": "journal article", "published": "2022-05-25", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "11", "issn-l": null}, "abstract": "The WHO/UNICEF Joint Monitoring Program (JMP) for Water Supply, Sanitation and Hygiene (WASH) produces global estimates of the real situation of access to water, sanitation and hygiene services, and sanitation and hygiene in households, educational institutes and health care facilities; however it is lacking data on schools in Kazakhstan. Thus, the aim of this research was to assess access to WASH in schools of urban area in Kazakhstan. The study was conducted in seven schools of Central Kazakhstan during the COVID-19 pandemic and restrictive measures. Three data collection methods were used: a questionnaire for administrative staff, a questionnaire for parents and observation. Parents of offline study pupils (only second and third grades due to the pandemic) were included in the survey. Students had access to in-building toilets in all schools connected to the centralized sewer. The number of school toilets varied from 7 (KAZ200085) to 61 (KAZ200089). The average amount of toilets was 28.08 \u00b1 16.97. Only two out of seven schools complied with the requirements of Kazakhstan national sanitary standards for the ratio of school toilets to the number of students. From the questionnaire with the school administrations, it was defined that the primary source of drinking water was the public water supply. All schools regularly disinfect and check the water supply system. At the same time, the results also revealed discrepancies in the answers between administration and parents (2.6% of parents showed that their children have rare access to drinking water), and insufficient monitoring of implementation of WASH services. This study also confirmed that the full provision of access to water and water services in the structure of educational institutions solves several SDG targets.", "doi": "10.3390/ijerph19116438", "pmid": "35682022", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19116438"}], "notes": [], "created": "2022-06-20T19:27:40.112Z", "modified": "2022-06-20T19:27:40.249Z"}, {"entity": "publication", "iuid": "cdf1dc4e16d74a99bdbc48ee13abcea5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cdf1dc4e16d74a99bdbc48ee13abcea5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cdf1dc4e16d74a99bdbc48ee13abcea5"}}, "title": "Amyloidogenesis of SARS-CoV-2 Spike Protein.", "authors": [{"family": "Nystr\u00f6m", "given": "Sofie", "initials": "S", "orcid": "0000-0002-4303-4783", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7996ddca29dc4632a0a37327ad0388b4.json"}}, {"family": "Hammarstr\u00f6m", "given": "Per", "initials": "P", "orcid": "0000-0001-5827-3587", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b57ea4fc5c2842628fe34bb8cda78889.json"}}], "type": "journal article", "published": "2022-05-25", "journal": {"title": "J Am Chem Soc", "issn": "1520-5126", "volume": "144", "issue": "20", "pages": "8945-8950", "issn-l": null}, "abstract": "SARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances together with neurologic and cardiac problems led us to investigate the amyloidogenicity of the SARS-CoV-2 spike protein (S-protein). Amyloid fibril assays of peptide library mixtures and theoretical predictions identified seven amyloidogenic sequences within the S-protein. All seven peptides in isolation formed aggregates during incubation at 37 \u00b0C. Three 20-amino acid long synthetic spike peptides (sequence 192-211, 601-620, 1166-1185) fulfilled three amyloid fibril criteria: nucleation dependent polymerization kinetics by ThT, Congo red positivity, and ultrastructural fibrillar morphology. Full-length folded S-protein did not form amyloid fibrils, but amyloid-like fibrils with evident branching were formed during 24 h of S-protein coincubation with the protease neutrophil elastase (NE) in vitro. NE efficiently cleaved S-protein, rendering exposure of amyloidogenic segments and accumulation of the amyloidogenic peptide 194-203, part of the most amyloidogenic synthetic spike peptide. NE is overexpressed at inflamed sites of viral infection. Our data propose a molecular mechanism for potential amyloidogenesis of SARS-CoV-2 S-protein in humans facilitated by endoproteolysis. The prospective of S-protein amyloidogenesis in COVID-19 disease associated pathogenesis can be important in understanding the disease and long COVID-19.", "doi": "10.1021/jacs.2c03925", "pmid": "35579205", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T18:04:57.349Z", "modified": "2022-06-21T18:04:57.462Z"}, {"entity": "publication", "iuid": "76e6763d7f8044789c7df8692fde2bd3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76e6763d7f8044789c7df8692fde2bd3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76e6763d7f8044789c7df8692fde2bd3"}}, "title": "Venerable vulnerability or remarkable resilience? A prospective study of the impact of the first wave of the COVID-19 pandemic and quarantine measures on loneliness in Swedish older adults with home care.", "authors": [{"family": "Gustafsson", "given": "Per E", "initials": "PE", "orcid": "0000-0002-3972-5362", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9ac282ae534432f9e8135a8070683bc.json"}}, {"family": "Nilsson", "given": "Ingeborg", "initials": "I"}, {"family": "San Sebastian", "given": "Miguel", "initials": "M"}], "type": "journal article", "published": "2022-05-24", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "5", "pages": "e060209", "issn-l": "2044-6055"}, "abstract": "To examine the early impact of the pandemic and of quarantine measures targeting older adults introduced in March 2020 on loneliness among older adults in Sweden.Design Prospective pretest-posttest and controlled interrupted time series designs.\n\nThe population of older adults receiving home care before and during the emergence of the first COVID-19 pandemic wave in Sweden in Spring 2020.\n\nRespondents (n=45 123, mean age 85.6 years, 67.6% women) came from two waves of a total population survey targeting all community-dwelling older adults receiving home care for older adults in Sweden in Spring 2019 and 2020.\n\nSelf-reported loneliness.\n\nResults estimated 14% (95% CI: 10 to 19) higher loneliness in Spring 2020 compared with 2019, taking covariates into account. No impact of the quarantine measure was found (1% increase, 95% CI: -1 to 4).\n\nThe results illustrate the broader public health consequences of the COVID-19 pandemic for older adults, but also suggest a relative resilience among older adults in home care to quarantine measures, at least during the first months of the pandemic. Future studies should examine the long-term effects of sustained pandemic and social distancing measures on loneliness among older adults.", "doi": "10.1136/bmjopen-2021-060209", "pmid": "35613816", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-060209"}], "notes": [], "created": "2022-06-21T17:50:27.186Z", "modified": "2022-06-21T17:50:27.216Z"}, {"entity": "publication", "iuid": "0c4f666e5c354548a2cfcebd30d440c3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c4f666e5c354548a2cfcebd30d440c3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c4f666e5c354548a2cfcebd30d440c3"}}, "title": "Antimicrobial use in Sweden during the COVID-19 pandemic: prescription fill and inpatient care requisition patterns.", "authors": [{"family": "Nakitanda", "given": "Aya Olivia", "initials": "AO"}, {"family": "Karlsson", "given": "P\u00e4r", "initials": "P"}, {"family": "L\u00f6fling", "given": "Lukas", "initials": "L"}, {"family": "Cesta", "given": "Carolyn E", "initials": "CE"}, {"family": "Odsbu", "given": "Ingvild", "initials": "I"}], "type": "journal article", "published": "2022-05-24", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "volume": "22", "issue": "1", "pages": "492", "issn-l": null}, "abstract": "Increased and inappropriate antimicrobial use are the key drivers of the emergence of antimicrobial resistance, and there have been widespread concerns around potential antimicrobial misuse, overuse and their consequences during the COVID-19 pandemic. To better understand the impact of the pandemic on antimicrobial use, particularly in light of the resurgence of COVID-19 cases since the summer of 2020, we assessed trends in antimicrobial prescription fills and hospital requisitions in Sweden during 2020 against those of preceding years.\n\nWe performed a descriptive study using population-based data from the Swedish Prescribed Drug Register and the Swedish e-Health Agency. The weekly number of prescriptions filled and the total volume sold to inpatient care institutions in defined daily doses (DDDs) per 1000 inhabitants for systemic antibacterials (Anatomical Therapeutic Chemical therapeutic subgroup J01 excluding J01XX), antimycotics (J02), antivirals (J05) and antiprotozoals (P01) were computed and evaluated from time series graphs. A time series linear regression with ordinary least squares (OLS) estimation was used to model 2015-2019 data and predict the expected number of prescriptions filled and volumes sold in DDDs per 1000 inhabitants during 2020 with 95% confidence limits.\n\nFrom mid-March 2020, the weekly rate of antibiotic and antiprotozoal prescriptions filled plummeted to unprecedentedly low levels for the rest of the year; while unprecedentedly high numbers of antiviral prescriptions were filled weekly between mid-February and mid-March 2020. There was a net reduction in annual dispensing of antibiotics by 17%; of antiprotozoals by 21%; and of antivirals by 0.3% during 2020 compared to 2019. Inpatient care requisitions of antiprotozoals and antibiotics surged to 6-year highs during March 2020, resulting in a 127% increase in DDDs of antiprotozoals sold from 2019. The volume of antibiotics and antivirals sold to inpatient care institutions in 2020 decreased by 3% and 13% compared to 2019, respectively.\n\nThe overall decline in antimicrobial prescriptions filled in Sweden during 2020 were in part, collateral dividends of the COVID-19 pandemic.", "doi": "10.1186/s12879-022-07405-3", "pmid": "35610597", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC9128331"}, {"db": "pii", "key": "10.1186/s12879-022-07405-3"}], "notes": [], "created": "2023-01-13T13:37:43.906Z", "modified": "2023-01-13T13:37:43.909Z"}, {"entity": "publication", "iuid": "385d9bb6a0ce4897a3dc84dce0af7a1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/385d9bb6a0ce4897a3dc84dce0af7a1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/385d9bb6a0ce4897a3dc84dce0af7a1d"}}, "title": "Editorial: The Consequences of COVID-19 on the Mental Well-Being of Parents, Children and Adolescents.", "authors": [{"family": "Sorbring", "given": "Emma", "initials": "E"}, {"family": "Svensson", "given": "Ylva", "initials": "Y"}, {"family": "Erlandsson", "given": "Soly I", "initials": "SI"}, {"family": "Deater-Deckard", "given": "Kirby", "initials": "K"}], "type": "editorial", "published": "2022-05-23", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "13", "pages": "924599", "issn-l": "1664-0640"}, "abstract": null, "doi": "10.3389/fpsyt.2022.924599", "pmid": "35677874", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC9168802"}], "notes": [], "created": "2022-06-20T19:30:16.042Z", "modified": "2022-06-20T19:30:30.212Z"}, {"entity": "publication", "iuid": "3284070f61ac48e3a02443b00a603a24", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3284070f61ac48e3a02443b00a603a24.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3284070f61ac48e3a02443b00a603a24"}}, "title": "The spoils of war and the long-term spoiling of health conditions of entire nations.", "authors": [{"family": "Navarese", "given": "Eliano P", "initials": "EP"}, {"family": "Grzelakowska", "given": "Klaudyna", "initials": "K"}, {"family": "Mangini", "given": "Francesco", "initials": "F"}, {"family": "Kubica", "given": "Jacek", "initials": "J"}, {"family": "Banach", "given": "Maciej", "initials": "M"}, {"family": "Benn", "given": "Marianne", "initials": "M"}, {"family": "Binder", "given": "Christoph J", "initials": "CJ"}, {"family": "Bor\u00e9n", "given": "Jan", "initials": "J"}, {"family": "Catapano", "given": "Alberico", "initials": "A"}, {"family": "Kronenberg", "given": "Florian", "initials": "F"}, {"family": "Mallat", "given": "Ziad", "initials": "Z"}, {"family": "Moulin", "given": "Philippe", "initials": "P"}, {"family": "\u00d6\u00f6rni", "given": "Katariina", "initials": "K"}, {"family": "Ray", "given": "Kausik K", "initials": "KK"}, {"family": "Roeters van Lennep", "given": "Jeanine E", "initials": "JE"}, {"family": "Romeo", "given": "Stefano", "initials": "S"}, {"family": "Tokgozoglu", "given": "Lale", "initials": "L"}, {"family": "von Eckardstein", "given": "Arnold", "initials": "A"}, {"family": "Zambon", "given": "Alberto", "initials": "A"}, {"family": "Raggi", "given": "Paolo", "initials": "P"}], "type": "editorial", "published": "2022-05-21", "journal": {"title": "Atherosclerosis", "issn": "1879-1484", "issn-l": null}, "abstract": "The healthcare system of Ukraine was already suffering from several shortfalls before February 2022, but the war of aggression started by the Russian leadership is poised to inflict a further severe blow that will have long-lasting consequences for the health of all Ukrainians. In pre-war Ukraine, noncommunicable diseases (NCDs) contributed to 91% of deaths, especially cardiovascular diseases (67%). Ukrainians have a high prevalence of risk factors for NCDs ranking among the highest levels reported by the World Health Organization (WHO) in the European (EU) Region. Cardiovascular disease is one of the key health risks for the conflict-affected Ukrainian population due to significant limitations in access to health care and interruptions in the supply of medicines and resources. The excess mortality observed during the COVID-19 pandemic, due to a combination of viral illness and chronic disease states, is bound to increase exponentially from poorly treated NCDs. In this report, we discuss the impact of the war on the public health of Ukraine and potential interventions to provide remote health assistance to the Ukrainian population.", "doi": "10.1016/j.atherosclerosis.2022.05.012", "pmid": "35644760", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0021-9150(22)00248-9"}], "notes": [], "created": "2022-06-21T17:34:06.754Z", "modified": "2022-06-21T17:34:06.790Z"}, {"entity": "publication", "iuid": "53dae477917e4ae38cd3d373c721a178", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53dae477917e4ae38cd3d373c721a178.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53dae477917e4ae38cd3d373c721a178"}}, "title": "Working With Refugees' Health During COVID-19-The Experience of Health- and Social Care Workers in Sweden.", "authors": [{"family": "Mangrio", "given": "Elisabeth", "initials": "E"}, {"family": "Zdravkovic", "given": "Slobodan", "initials": "S"}, {"family": "Strange", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2022-05-19", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "10", "pages": "811974", "issn-l": "2296-2565"}, "abstract": "In Sweden, often seen as one of the most egalitarian countries, the COVID-19 pandemic exposed high levels of health inequality, especially harming people with a refugee background. This is also despite Sweden's image as a refugee-friendly country. In this context, the aim of this paper is to better understand how Swedish health- and social workers have reacted to the health- and social needs of refugees during the pandemic. The Swedish case is particularly interesting because, as seen in the paper, health- and social workers had the task of communicating health guidance to refugees who were sometimes more reliant on information from abroad where the consensus on COVID-19 restrictions ran contrary to the approach recommended by the Swedish public health authority.\n\nThe study utilizes a qualitative content analysis of 13 in-depth interviews with health- and social workers in Sweden, active in the care of refugees within different kinds of health- and social care settings.\n\nThe analysis showed that healthcare services have remained open during the pandemic but with new precautions at reception areas impacting how refugees access healthcare. As discussed in the article, the shift to digital tools has particularly impacted refugees, worsening already existing barriers to healthcare services faced by those with refugee status. Public health recommendations were poorly designed to the needs of refugees whose living conditions often prevented them from self-isolation and social distancing. Furthermore, Sweden's initially non-restrictive approach to the pandemic instructed health- and social-workers to encourage refugees to take far fewer precautions (e.g., self-isolation, home-schooling, pregnant women to avoid virus hotspots) compared both with European neighbors and the international media typically used by refugees. When Sweden shifted toward a more restrictive approach, health- and social-workers had to revise their guidance in relation to the new recommendations around precautions.\n\nRefugees have faced increased barriers to maintaining their health and wellbeing during the pandemic that exceed those experienced by the rest of the Swedish population. Refugees have, in general, taken precautions in regard to social distancing and followed recommendations but faced challenges with social distancing due to isolation and crowded living. Public health authorities have often failed to acknowledge that individuals use increasingly diverse sources of knowledge when trying to protect their health, and that not everyone has access to the knowledge needed to access healthcare and social systems. At the same time, there is a need to acknowledge that refugees are sometimes a source of expertise that was ignored by the Swedish health and social system during the pandemic. There is a need for urgent efforts to halt the worsening health conditions for this specific group, but also to counter knock-on societal effects and rising health inequity.", "doi": "10.3389/fpubh.2022.811974", "pmid": "35669746", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9163396"}], "notes": [], "created": "2022-06-20T19:32:55.131Z", "modified": "2022-06-20T19:33:05.876Z"}, {"entity": "publication", "iuid": "dd82b322ce1f4cccb12ac2f9ebdccd6c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dd82b322ce1f4cccb12ac2f9ebdccd6c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dd82b322ce1f4cccb12ac2f9ebdccd6c"}}, "title": "The association between maternal characteristics and SARS-CoV-2 in pregnancy: a population-based registry study in Sweden and Norway.", "authors": [{"family": "\u00d6rtqvist", "given": "Anne K", "initials": "AK"}, {"family": "Magnus", "given": "Maria C", "initials": "MC"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Oakley", "given": "Laura", "initials": "L"}, {"family": "Nybo Andersen", "given": "Anne-Marie", "initials": "AM"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}], "type": "journal article", "published": "2022-05-19", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "8355", "issn-l": "2045-2322"}, "abstract": "The objectives of the current study were to identify risk factors for SARS-CoV-2 positivity, and to address how different testing strategies, choice of comparison group, and population background characteristics may influence observed associations. National registries data for 107,627 pregnant women in Sweden and 81,195 in Norway, were used to identify risk factors for SARS-CoV-2, separately for women under non-universal testing (testing by indication) and universal testing (testing of all pregnant women in contact with a delivery ward). We also investigated underlying characteristics associated with testing for SARS-CoV-2. Overall, 2.1% of pregnant women in Sweden and 1.1% in Norway were test-positive during the pandemic's first 18 months. We show that the choice of test strategy for SARS-CoV-2 provided different associations with risk factors for the disease; for instance, women who were overweight, obese or had gestational diabetes had increased odds of being test-positive under non-universal testing, but not under universal testing. Nevertheless, a consistent pattern of association between being born in the Middle East and Africa and test-positivity was found independent of test strategy and in both countries. These women were also less likely to get tested. Our results are useful to consider for surveillance and clinical recommendations for pregnant women during the current and future pandemics.", "doi": "10.1038/s41598-022-12395-y", "pmid": "35589871", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-12395-y"}, {"db": "pmc", "key": "PMC9120467"}], "notes": [], "created": "2022-06-21T18:00:33.000Z", "modified": "2022-06-21T18:00:44.440Z"}, {"entity": "publication", "iuid": "abc068b1ea5d4b08bad47d5041ef7217", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abc068b1ea5d4b08bad47d5041ef7217.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abc068b1ea5d4b08bad47d5041ef7217"}}, "title": "SARS-CoV-2 airway reactivity in children: more of the same?", "authors": [{"family": "Karlsson", "given": "J", "initials": "J", "orcid": "0000-0003-2277-0092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a428771f0dc41948d1d1e13131497bc.json"}}, {"family": "Johansen", "given": "M", "initials": "M"}, {"family": "Engelhardt", "given": "T", "initials": "T"}], "type": "editorial", "published": "2022-05-19", "journal": {"title": "Anaesthesia", "issn": "1365-2044", "issn-l": "0003-2409"}, "abstract": null, "doi": "10.1111/anae.15760", "pmid": "35587812", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T18:01:57.625Z", "modified": "2022-06-21T18:01:57.680Z"}, {"entity": "publication", "iuid": "298d8af4f737432192eebe7e304e2165", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/298d8af4f737432192eebe7e304e2165.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/298d8af4f737432192eebe7e304e2165"}}, "title": "Pandemic responses at the subnational level: Exploring politics, administration, and politicization in Swedish municipalities.", "authors": [{"family": "Sparf", "given": "J\u00f6rgen", "initials": "J", "orcid": "0000-0002-0202-0609", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01828d7aea6742b1a425f44c5c0665cf.json"}}, {"family": "Petridou", "given": "Evangelia", "initials": "E", "orcid": "0000-0001-7316-4899", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21de455914874bdf8fbaf544e51053b0.json"}}, {"family": "Granberg", "given": "Mikael", "initials": "M", "orcid": "0000-0002-5356-4112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee3d0f0c22c749b8ac5ac2f2e09dc4b4.json"}}, {"family": "Becker", "given": "Per", "initials": "P", "orcid": "0000-0001-9379-9461", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b55e9fcbd1c44de2b8c10a5bad30888b.json"}}, {"family": "Onn", "given": "Beatrice", "initials": "B"}], "type": "journal article", "published": "2022-05-19", "journal": {"title": "Eur Policy Anal", "issn": "2380-6567", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The Swedish response to the pandemic at the national level has attracted considerable international attention, but little focus has been placed on the way municipalities dealt with the crisis. Using Hay's dimensions of politicization, namely the capacity for human agency, deliberation in the public domain, and social context, we analyze the politicization of the municipal response to the pandemic in Sweden. We do this based on the analysis of the decision making process to activate (or not) an extraordinary crisis management committee. We find inter alia, that (i) only a quarter of the municipalities activated the committee while a majority of them had an alternate special organization in place; (ii) support to the existing organizational structure was more salient than creating an extraordinary organization, and (iii) a robust municipal structure was deemed to be one able to withstand shocks without resorting to extraordinary governance arrangements. We find a 'conditioned politicization' of the response, privileging administration over politics.", "doi": "10.1002/epa2.1151", "pmid": "35942065", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "EPA21151"}, {"db": "pmc", "key": "PMC9347882"}], "notes": [], "created": "2022-08-11T11:50:43.127Z", "modified": "2022-11-09T08:42:43.355Z"}, {"entity": "publication", "iuid": "2e39de17d4d34be682f9d98fa9e2c57b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e39de17d4d34be682f9d98fa9e2c57b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e39de17d4d34be682f9d98fa9e2c57b"}}, "title": "Pandemic impact on patients with advanced non-COVID-19 illness and their family carers receiving specialised palliative home care: a qualitative study.", "authors": [{"family": "Nyblom", "given": "Stina", "initials": "S", "orcid": "0000-0002-4998-0324", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9037f37fbb29422dab6a2a59a8d74a85.json"}}, {"family": "Benkel", "given": "Inger", "initials": "I"}, {"family": "Carling", "given": "Linn\u00e9a", "initials": "L"}, {"family": "L\u00f6fdahl", "given": "Elisabet", "initials": "E"}, {"family": "Molander", "given": "Ulla", "initials": "U"}, {"family": "\u00d6hl\u00e9n", "given": "Joakim", "initials": "J"}], "type": "journal article", "published": "2022-05-19", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "5", "pages": "e059577", "issn-l": "2044-6055"}, "abstract": "To investigate the experiential impact of the COVID-19 pandemic on patients with non-COVID, life-threatening disease and their family carers.\n\nAn interpretative qualitative design informed by phenomenological hermeneutics and based on data from in-depth interviews, performed between June and September 2020.\n\nPatients receiving specialised palliative home care and their family carers living in Sweden.\n\n22 patients (male/female 11/11) and 17 carers (male/female 5/12) aged 50 years and older. All the patients received specialised palliative home care and most were diagnosed with cancer.\n\naged 18 years or older, diagnosed with an incurable life-threatening, non-COVID disease, sufficient strength to participate and capacity to provide informed consent. Participants were selected through a combination of convenient and consecutive sampling.\n\nThe significance of the pandemic for both patients and carers showed a continuum from being minimally affected in comparison to the severe underlying disease to living in isolation with constant fear of becoming infected and falling ill with COVID-19, which some likened to torture.The imposed restrictions on social contact due to the pandemic were particularly palpable for this group of people with a non-COVID-19, life-limiting condition, as it was said to steal valuable moments of time that had already been measured.Most patients and carers found access to specialised palliative home care was maintained despite the pandemic. This care was of paramount importance for their sense of security and was often their sole visiting social contact.\n\nIn the pandemic situation, highly accessible support from healthcare and social care at home is particularly important to create security for both patients and carers. Thus, to provide appropriate support, it is important for healthcare and social care personnel to be aware of the great diversity of reactions patients in palliative care and their carers may have to a pandemic threat.", "doi": "10.1136/bmjopen-2021-059577", "pmid": "35589359", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-059577"}, {"db": "pmc", "key": "PMC9121113"}], "notes": [], "created": "2022-06-21T18:00:58.929Z", "modified": "2022-06-21T18:00:58.991Z"}, {"entity": "publication", "iuid": "6b86554ba821470f8ff9bbc8e29a8a0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b86554ba821470f8ff9bbc8e29a8a0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b86554ba821470f8ff9bbc8e29a8a0e"}}, "title": "Optimal Drug Regimen and Combined Drug Therapy and Its Efficacy in the Treatment of COVID-19: A Within-Host Modeling Study.", "authors": [{"family": "Chhetri", "given": "Bishal", "initials": "B"}, {"family": "Bhagat", "given": "Vijay M", "initials": "VM"}, {"family": "Vamsi", "given": "D K K", "initials": "DKK", "orcid": "0000-0002-1296-0135", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea3460b1791047619e40a7b1af74e040.json"}}, {"family": "Ananth", "given": "V S", "initials": "VS"}, {"family": "Prakash", "given": "Bhanu", "initials": "B"}, {"family": "Muthusamy", "given": "Swapna", "initials": "S"}, {"family": "Deshmukh", "given": "Pradeep", "initials": "P"}, {"family": "Sanjeevi", "given": "Carani B", "initials": "CB"}], "type": "journal article", "published": "2022-05-19", "journal": {"title": "Acta Biotheor", "issn": "1572-8358", "volume": "70", "issue": "2", "pages": "16", "issn-l": null}, "abstract": "The COVID-19 pandemic has resulted in more than 524 million cases and 6 million deaths worldwide. Various drug interventions targeting multiple stages of COVID-19 pathogenesis can significantly reduce infection-related mortality. The current within-host mathematical modeling study addresses the optimal drug regimen and efficacy of combination therapies in the treatment of COVID-19. The drugs/interventions considered include Arbidol, Remdesivir, Interferon (INF) and Lopinavir/Ritonavir. It is concluded that these drugs, when administered singly or in combination, reduce the number of infected cells and viral load. Four scenarios dealing with the administration of a single drug, two drugs, three drugs and all four are discussed. In all these scenarios, the optimal drug regimen is proposed based on two methods. In the first method, these medical interventions are modeled as control interventions and a corresponding objective function and optimal control problem are formulated. In this framework, the optimal drug regimen is derived. Later, using the comparative effectiveness method, the optimal drug regimen is derived based on the basic reproduction number and viral load. The average number of infected cells and viral load decreased the most when all four drugs were used together. On the other hand, the average number of susceptible cells decreased the most when Arbidol was administered alone. The basic reproduction number and viral load decreased the most when all four interventions were used together, confirming the previously obtained finding of the optimal control problem. The results of this study can help physicians make decisions about the treatment of the life-threatening COVID-19 infection.", "doi": "10.1007/s10441-022-09440-8", "pmid": "35588019", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10441-022-09440-8"}, {"db": "pmc", "key": "PMC9118007"}], "notes": [], "created": "2022-06-21T18:01:41.810Z", "modified": "2022-06-21T18:01:43.241Z"}, {"entity": "publication", "iuid": "bb58767a28484d2fbd148fb1a9341e6d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb58767a28484d2fbd148fb1a9341e6d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb58767a28484d2fbd148fb1a9341e6d"}}, "title": "TTCOV19: timing of tracheotomy in SARS-CoV-2-infected patients: a multicentre, single-blinded, randomized, controlled trial.", "authors": [{"family": "Eeg-Olofsson", "given": "M\u00e5ns", "initials": "M"}, {"family": "Pauli", "given": "Nina", "initials": "N"}, {"family": "Hafsten", "given": "Louise", "initials": "L"}, {"family": "Jacobsson", "given": "Josephine", "initials": "J"}, {"family": "Lundborg", "given": "Christopher", "initials": "C"}, {"family": "Brink", "given": "Magnus", "initials": "M"}, {"family": "Larsson", "given": "Helen", "initials": "H"}, {"family": "Lindell", "given": "Ellen", "initials": "E"}, {"family": "L\u00f6whagen", "given": "Karin", "initials": "K"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Bergquist", "given": "Henrik", "initials": "H"}], "type": "journal article", "published": "2022-05-18", "journal": {"title": "Crit Care", "issn": "1466-609X", "volume": "26", "issue": "1", "pages": "142", "issn-l": "1364-8535"}, "abstract": "Critically ill COVID-19 patients may develop acute respiratory distress syndrome and the need for respiratory support, including mechanical ventilation in the intensive care unit. Previous observational studies have suggested early tracheotomy to be advantageous. The aim of this parallel, multicentre, single-blinded, randomized controlled trial was to evaluate the optimal timing of tracheotomy.\n\nSARS-CoV-2-infected patients within the Region V\u00e4stra G\u00f6taland of Sweden who needed intubation and mechanical respiratory support were included and randomly assigned to early tracheotomy (\u2264 7 days after intubation) or late tracheotomy (\u2265 10 days after intubation). The primary objective was to compare the total number of mechanical ventilation days between the groups.\n\nOne hundred fifty patients (mean age 65 years, 79% males) were included. Seventy-two patients were assigned to early tracheotomy, and 78 were assigned to late tracheotomy. One hundred two patients (68%) underwent tracheotomy of whom sixty-one underwent tracheotomy according to the protocol. The overall median number of days in mechanical ventilation was 18 (IQR 9; 28), but no significant difference was found between the two treatment regimens in the intention-to-treat analysis (between-group difference: - 1.5 days (95% CI - 5.7 to 2.8); p = 0.5). A significantly reduced number of mechanical ventilation days was found in the early tracheotomy group during the per-protocol analysis (between-group difference: - 8.0 days (95% CI - 13.8 to - 2.27); p = 0.0064). The overall correlation between the timing of tracheotomy and days of mechanical ventilation was significant (Spearman's correlation: 0.39, p < 0.0001). The total death rate during intensive care was 32.7%, but no significant differences were found between the groups regarding survival, complications or adverse events.\n\nThe potential superiority of early tracheotomy when compared to late tracheotomy in critically ill patients with COVID-19 was not confirmed by the present randomized controlled trial but is a strategy that should be considered in selected cases where the need for MV for more than 14 days cannot be ruled out. Trial registration NCT04412356 , registered 05/24/2020.", "doi": "10.1186/s13054-022-04005-0", "pmid": "35585614", "labels": {"Category: Biochemistry": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-022-04005-0"}, {"db": "pmc", "key": "PMC9115544"}, {"db": "ClinicalTrials.gov", "key": "NCT04412356"}], "notes": [], "created": "2022-06-21T18:02:19.433Z", "modified": "2022-06-21T18:02:19.446Z"}, {"entity": "publication", "iuid": "bf86788503da4c2a9f9fbc540cb775a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf86788503da4c2a9f9fbc540cb775a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf86788503da4c2a9f9fbc540cb775a0"}}, "title": "Impacts of COVID-19 on people and sea: marine social science imaginations.", "authors": [{"family": "Knutsson", "given": "Per", "initials": "P"}, {"family": "Bavinck", "given": "Maarten", "initials": "M"}], "type": "journal article", "published": "2022-05-18", "journal": {"title": "Marit Stud", "issn": "2212-9790", "issn-l": null, "volume": "21", "issue": "2", "pages": "155-158"}, "abstract": null, "doi": "10.1007/s40152-022-00270-5", "pmid": "35601845", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "270"}, {"db": "pmc", "key": "PMC9114292"}], "notes": [], "created": "2022-06-21T17:56:05.333Z", "modified": "2022-11-22T05:37:52.688Z"}, {"entity": "publication", "iuid": "1b2b7251165d4c37a0d4ec7f404f552a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b2b7251165d4c37a0d4ec7f404f552a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b2b7251165d4c37a0d4ec7f404f552a"}}, "title": "Explaining the complex impact of the Covid-19 pandemic on children with overweight and obesity: a comparative ecological analysis of parents' perceptions in three countries.", "authors": [{"family": "Nowicka", "given": "P", "initials": "P"}, {"family": "Ek", "given": "A", "initials": "A"}, {"family": "Jurca-Simina", "given": "I E", "initials": "IE"}, {"family": "Bouzas", "given": "C", "initials": "C"}, {"family": "Argelich", "given": "E", "initials": "E"}, {"family": "Nordin", "given": "K", "initials": "K"}, {"family": "Garc\u00eda", "given": "S", "initials": "S"}, {"family": "Vasquez Barquero", "given": "M Y", "initials": "MY"}, {"family": "Hoffer", "given": "U", "initials": "U"}, {"family": "Reijs Richards", "given": "H", "initials": "H"}, {"family": "Tur", "given": "J A", "initials": "JA"}, {"family": "Chirita-Emandi", "given": "A", "initials": "A"}, {"family": "Eli", "given": "K", "initials": "K"}], "type": "journal article", "published": "2022-05-17", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "1000", "issn-l": null}, "abstract": "The Covid-19 pandemic has changed children's eating and physical activity behaviours. These changes have been positive for some households and negative for others, revealing health inequalities that have ramifications for childhood obesity. This study investigates the pandemic's impact on families of children aged 2-6 years with overweight or obesity.\n\nDrawing on interviews conducted as part of a randomised controlled trial (RCT) for childhood obesity, thematic analysis was used to examine how parents of pre-schoolers perceived changes in their eating, screentime and physical activity behaviours between the first and second waves of Covid-19. Parents (n = 70, representing 68 families) were interviewed twice during a period of 6 months in three countries with markedly different pandemic policies - Sweden, Romania, and Spain. The analysis is informed by Bronfenbrenner's ecological systems theory, which embeds home- and school-based influences within societal and policy contexts.\n\nThe findings show that, although all participants were recruited from an RCT for families of children with excess weight, they reported different responses to the pandemic's second wave, with some children engaging in healthier eating and physical activity, and others engaging in comfort eating and a more sedentary lifestyle. Differences in children's obesity-related behaviours were closely related to differences in parents' practices, which were, in turn, linked to their emotional and social wellbeing. Notably, across all sites, parents' feeding and physical activity facilitation practices, as well as their emotional and social wellbeing, were embedded in household resilience. In resilient households, where parents had secure housing and employment, they were better able to adapt to the challenges posed by the pandemic, whereas parents who experienced household insecurity found it more difficult to cope.\n\nAs the Covid-19 pandemic is turning into a long-term public health challenge, studies that address household resilience are crucial for developing effective prevention and treatment responses to childhood obesity.", "doi": "10.1186/s12889-022-13351-1", "pmid": "35581642", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-022-13351-1"}, {"db": "pmc", "key": "PMC9113066"}], "notes": [], "created": "2022-06-21T18:04:35.017Z", "modified": "2022-06-21T18:04:35.030Z"}, {"entity": "publication", "iuid": "8db5b4dcddc6416aafb66df37925e9b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8db5b4dcddc6416aafb66df37925e9b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8db5b4dcddc6416aafb66df37925e9b1"}}, "title": "Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm.", "authors": [{"family": "Yang", "given": "Huan", "initials": "H", "orcid": "0000-0001-8796-5523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c22b8c5acc94b878afde7fc4e39c378.json"}}, {"family": "George", "given": "Sam J", "initials": "SJ"}, {"family": "Thompson", "given": "Dane A", "initials": "DA"}, {"family": "Silverman", "given": "Harold A", "initials": "HA"}, {"family": "Tsaava", "given": "T\u00e9a", "initials": "T"}, {"family": "Tynan", "given": "Aisling", "initials": "A"}, {"family": "Pavlov", "given": "Valentin A", "initials": "VA"}, {"family": "Chang", "given": "Eric H", "initials": "EH"}, {"family": "Andersson", "given": "Ulf", "initials": "U"}, {"family": "Brines", "given": "Michael", "initials": "M"}, {"family": "Chavan", "given": "Sangeeta S", "initials": "SS"}, {"family": "Tracey", "given": "Kevin J", "initials": "KJ"}], "type": "journal article", "published": "2022-05-16", "journal": {"title": "Mol Med", "issn": "1528-3658", "volume": "28", "issue": "1", "pages": "57", "issn-l": "1076-1551"}, "abstract": "Severe COVID-19 is characterized by pro-inflammatory cytokine release syndrome (cytokine storm) which causes high morbidity and mortality. Recent observational and clinical studies suggest famotidine, a histamine 2 receptor (H2R) antagonist widely used to treat gastroesophageal reflux disease, attenuates the clinical course of COVID-19. Because evidence is lacking for a direct antiviral activity of famotidine, a proposed mechanism of action is blocking the effects of histamine released by mast cells. Here we hypothesized that famotidine activates the inflammatory reflex, a brain-integrated vagus nerve mechanism which inhibits inflammation via alpha 7 nicotinic acetylcholine receptor (\u03b17nAChR) signal transduction, to prevent cytokine storm.\n\nThe potential anti-inflammatory effects of famotidine and other H2R antagonists were assessed in mice exposed to lipopolysaccharide (LPS)-induced cytokine storm. As the inflammatory reflex is integrated and can be stimulated in the brain, and H2R antagonists penetrate the blood brain barrier poorly, famotidine was administered by intracerebroventricular (ICV) or intraperitoneal (IP) routes.\n\nFamotidine administered IP significantly reduced serum and splenic LPS-stimulated tumor necrosis factor (TNF) and IL-6 concentrations, significantly improving survival. The effects of ICV famotidine were significantly more potent as compared to the peripheral route. Mice lacking mast cells by genetic deletion also responded to famotidine, indicating the anti-inflammatory effects are not mast cell-dependent. Either bilateral sub-diaphragmatic vagotomy or genetic knock-out of \u03b17nAChR abolished the anti-inflammatory effects of famotidine, indicating the inflammatory reflex as famotidine's mechanism of action. While the structurally similar H2R antagonist tiotidine displayed equivalent anti-inflammatory activity, the H2R antagonists cimetidine or ranitidine were ineffective even at very high dosages.\n\nThese observations reveal a previously unidentified vagus nerve-dependent anti-inflammatory effect of famotidine in the setting of cytokine storm which is not replicated by high dosages of other H2R antagonists in clinical use. Because famotidine is more potent when administered intrathecally, these findings are also consistent with a primarily central nervous system mechanism of action.", "doi": "10.1186/s10020-022-00483-8", "pmid": "35578169", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s10020-022-00483-8"}, {"db": "pmc", "key": "PMC9109205"}], "notes": [], "created": "2022-06-21T18:05:26.861Z", "modified": "2022-06-21T18:05:26.918Z"}, {"entity": "publication", "iuid": "290bd3e7e98540d4a01daf46ec50d260", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/290bd3e7e98540d4a01daf46ec50d260.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/290bd3e7e98540d4a01daf46ec50d260"}}, "title": "Expecting parents' perceptions of the digital parental support \"childbirth journey\" constructed as a serious game-an intervention study.", "authors": [{"family": "B\u00e4ckstr\u00f6m", "given": "Caroline", "initials": "C", "orcid": "0000-0003-3347-482X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/362a5834f28143df864284ea02c275d8.json"}}, {"family": "Rolfson", "given": "Tanja", "initials": "T"}, {"family": "Engstr\u00f6m", "given": "Henrik", "initials": "H"}, {"family": "Knez", "given": "Rajna", "initials": "R"}, {"family": "Larsson", "given": "Margaretha", "initials": "M"}], "type": "journal article", "published": "2022-05-16", "journal": {"title": "Digit Health", "issn": "2055-2076", "volume": "8", "pages": "20552076221097776", "issn-l": null}, "abstract": "The aim of this study was to explore expecting parents' perceptions of the Childbirth Journey as an intervention that includes medical information for parental support, constructed as a serious game.\n\nIn this qualitative study, semi-structured interviews were held with expecting parents in Sweden who were able to talk about specific parts of the Childbirth Journey they appreciated or found difficult to understand. A phenomenographic methodology was employed for data analysis.\n\nParticipants perceived the Childbirth Journey to be easily accessible and customized with reliable information. The design and features of the intervention were perceived by the expecting parents to enhance the intervention's usability, appeal, and trustworthiness. When parental couples used the Childbirth Journey together, it gave them an opportunity to discuss and better understand each other's situation. The participants proposed several changes to the existing version of the game, mostly related to extending practical information and illustrated scenarios but also to the further development of the game's design and animations. The participants found the Knowledge portal to be the most appealing part of the Childbirth Journey.\n\nThe Childbirth Journey intervention was concluded to be a valuable digital complement to in-person professional support, especially given the current COVID-19 pandemic restrictions in place in Sweden, which do not allow antenatal visits by partners. However, in its current form, the Childbirth Journey has some deficiencies and would therefore benefit from further development and exploration.", "doi": "10.1177/20552076221097776", "pmid": "35603330", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1177_20552076221097776"}, {"db": "pmc", "key": "PMC9118415"}], "notes": [], "created": "2022-06-21T17:54:46.934Z", "modified": "2022-06-21T17:54:47.025Z"}, {"entity": "publication", "iuid": "3602a2b29b9e424cb4e96bbc15b426bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3602a2b29b9e424cb4e96bbc15b426bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3602a2b29b9e424cb4e96bbc15b426bf"}}, "title": "Complex Mutation Pattern of Omicron BA.2: Evading Antibodies without Losing Receptor Interactions.", "authors": [{"family": "Kannan", "given": "Saathvik R", "initials": "SR"}, {"family": "Spratt", "given": "Austin N", "initials": "AN"}, {"family": "Sharma", "given": "Kalicharan", "initials": "K", "orcid": "0000-0003-0333-2521", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/866b6de8eb3d4073a864e907c70a2c4d.json"}}, {"family": "Goyal", "given": "Ramesh", "initials": "R"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Apparsundaram", "given": "Subbu", "initials": "S"}, {"family": "Lorson", "given": "Christian L", "initials": "CL", "orcid": "0000-0002-1023-2169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58e32f41dbfe4d8a9c1debb7243baa61.json"}}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN", "orcid": "0000-0002-6889-4640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4cbe48df5ac74ffcb8a16b4f6775be1f.json"}}, {"family": "Singh", "given": "Kamal", "initials": "K", "orcid": "0000-0001-6153-8929", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b751253db0945c2b78dc4361b522a19.json"}}], "type": "journal article", "published": "2022-05-16", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "23", "issue": "10", "issn-l": null}, "abstract": "BA.2, a sublineage of Omicron BA.1, is now prominent in many parts of the world. Early reports have indicated that BA.2 is more infectious than BA.1. To gain insight into BA.2 mutation profile and the resulting impact of mutations on interactions with receptor and/or monoclonal antibodies, we analyzed available sequences, structures of Spike/receptor and Spike/antibody complexes, and conducted molecular dynamics simulations. The results showed that BA.2 had 50 high-prevalent mutations, compared to 48 in BA.1. Additionally, 17 BA.1 mutations were not present in BA.2. Instead, BA.2 had 19 unique mutations and a signature Delta variant mutation (G142D). The BA.2 had 28 signature mutations in Spike, compared to 30 in BA.1. This was due to two revertant mutations, S446G and S496G, in the receptor-binding domain (RBD), making BA.2 somewhat similar to Wuhan-Hu-1 (WT), which had G446 and G496. The molecular dynamics simulations showed that the RBD consisting of G446/G496 was more stable than S446/S496 containing RBD. Thus, our analyses suggested that BA.2 evolved with novel mutations (i) to maintain receptor binding similar to WT, (ii) evade the antibody binding greater than BA.1, and (iii) acquire mutation of the Delta variant that may be associated with the high infectivity.", "doi": "10.3390/ijms23105534", "pmid": "35628343", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Category: Omicron VoC": null}, "xrefs": [{"db": "pii", "key": "ijms23105534"}], "notes": [], "created": "2022-06-21T17:40:33.765Z", "modified": "2022-06-21T17:40:43.645Z"}, {"entity": "publication", "iuid": "673d03ccbe7d4a669271abf771c68df8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/673d03ccbe7d4a669271abf771c68df8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/673d03ccbe7d4a669271abf771c68df8"}}, "title": "Intention to get COVID-19 vaccination and its associated predictors: A cross-sectional study among the general public in Algeria.", "authors": [{"family": "Lounis", "given": "Mohamed", "initials": "M"}, {"family": "Abdelhadi", "given": "Samir", "initials": "S"}, {"family": "Rais", "given": "Mohammed Amir", "initials": "MA"}, {"family": "Bencherit", "given": "Djihad", "initials": "D"}, {"family": "Sallam", "given": "Malik", "initials": "M"}], "type": "journal article", "published": "2022-05-13", "journal": {"title": "Vacunas", "issn": "1576-9887", "issn-l": null}, "abstract": "Hesitancy towards COVID-19 vaccination and its rejection remains a major public health concern worldwide, especially in the Middle East and North African countries. The current study aimed to assess the intentions to get COVID-19 vaccines and its determinants among the general public in Algeria.\n\nA self-administered online survey was distributed during August-September 2021 using a convenience-based sampling approach. Data were collected anonymously and analyzed using IBM SPSS v22.0 software.\n\nThe study sample comprised a total of 656 participants, with 51.1% being in favor of COVID-19 vaccines while 18.5% and 30.5% were against or hesitant respectively. Only 38.6% among the study participants got vaccinated. Factors associated with higher odds of acceptance were: male sex, healthcare profession, the belief in natural origin of the pandemic and previous COVID-19 infection in family. The most common cited reasons for COVID-19 vaccine acceptance were the belief that vaccination is the only way to fight COVID-19 and the fear of getting infected by the virus; while the most common reasons of rejection were lack of trust in proper vaccine testing and fear of side effects.\n\nThe overall level of COVID-19 vaccine acceptance in this study was below the levels required to achieve population immunity. Besides certain socio-demographic characteristics, the determinants of COVID-19 vaccine rejection included the embrace of conspiratorial ideas regarding the virus and its vaccination. This should be considered in implementation of interventional measures aiming to promote COVID-19 vaccination in the country.", "doi": "10.1016/j.vacun.2022.04.003", "pmid": "35813989", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1576-9887(22)00039-5"}, {"db": "pmc", "key": "PMC9256516"}], "notes": [], "created": "2022-08-17T10:38:52.801Z", "modified": "2022-08-17T10:38:52.837Z"}, {"entity": "publication", "iuid": "0d15c6a7e22d443f955437406fe427cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d15c6a7e22d443f955437406fe427cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d15c6a7e22d443f955437406fe427cf"}}, "title": "COVID-19 Impact on Household Food Security in Urban and Peri-Urban Areas of Hyderabad, India.", "authors": [{"family": "Padmaja", "given": "Ravula", "initials": "R"}, {"family": "Nedumaran", "given": "Swamikannu", "initials": "S"}, {"family": "Jyosthnaa", "given": "Padmanabhan", "initials": "P"}, {"family": "Kavitha", "given": "Kasala", "initials": "K"}, {"family": "Abu Hatab", "given": "Assem", "initials": "A"}, {"family": "Lagerkvist", "given": "Carl-Johan", "initials": "CJ"}], "type": "journal article", "published": "2022-05-13", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "10", "pages": "814112", "issn-l": "2296-2565"}, "abstract": "This paper investigates the impact of the COVID-19 pandemic on food security and on coping-strategies in urban and peri-urban areas of the Hyderabad, India. Household survey data were collected before (October 2018) and during (January 2021) the onset of the pandemic. Results from logistic regression with the standarized Food Insecurity Expecience Scale (FIES) as dependent variable reveal that close to 40% of the households surveyed experienced a deterioration in food security status during the pandemic. In particular, we find that food security is closely related to the sector of employment in which the primary income- earning member of a household is engaged. To mitigate the impact of the pandemic on their food security, our sampled households adopted a variety of consumption-smoothing strategies including availing credit from both formal and informal sources, and liquidating their savings. Compared to households with severe or moderate level of food insecurity, households facing a mild level of food insecurity relied on stored food as a strategy to smoothen consumption in response to the income shock imparted by the pandemic. In addition, the results indicate that urban households, who adopted similar coping strategies as those adopted by peri-urban households, tended to be more food-insecure. Finally, the duration of unemployment experienced during the pandemic significantly influenced the status of household food security. These findings can inform the formulation of immediate and medium-term policy responses, including social protection policies conductive to mitigating the impacts of the COVID-19 pandemic and ameliorating the governance of urban food security during unexpected events and shocks.", "doi": "10.3389/fpubh.2022.814112", "pmid": "35646805", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9136225"}], "notes": [], "created": "2022-06-21T17:33:21.216Z", "modified": "2022-06-21T17:33:21.232Z"}, {"entity": "publication", "iuid": "50a3e8646978441c839206df02532bc5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50a3e8646978441c839206df02532bc5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50a3e8646978441c839206df02532bc5"}}, "title": "Quality of the Healthcare Services During COVID-19 Pandemic in Selected European Countries.", "authors": [{"family": "Tuczy\u0144ska", "given": "Magdalena", "initials": "M"}, {"family": "Staszewski", "given": "Rafa\u0142", "initials": "R"}, {"family": "Matthews-Kozanecka", "given": "Maja", "initials": "M"}, {"family": "\u017bok", "given": "Agnieszka", "initials": "A"}, {"family": "Baum", "given": "Ewa", "initials": "E"}], "type": "journal article", "published": "2022-05-12", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "10", "pages": "870314", "issn-l": "2296-2565"}, "abstract": "There are several definitions of the quality of healthcare services. It may be defined as a level of value provided by any health care resource, as determined by some measurement. Scientists use a variety of quality measures to attempt to determine health care quality. They use special indicators or based on a patients' or healthcare professional's perception. This article aims to provide a short review of the available data on the quality of healthcare services in selected European countries during the COVID-19 pandemic.\n\nThe research was done by the use of online databases such as PubMed, Google Scholar, and Science Direct. All the studies focused on the quality of healthcare services, yet the studies used different methods to measure this quality. In addition, the results of the authors' survey on the assessment of the quality of healthcare services before and during the COVID-19 pandemic were presented.\n\nAmong twelve studies, four were from the United Kingdom and one each of Catalonia, Italy, Sweden, Poland, Netherlands, France, Germany, Belgium. Patients in the United Kingdom felt that the quality of services was good during the pandemic, whereas the quality declined in the other studies cited. The results of our research also revealed a decrease in the quality of healthcare services provided.\n\nNevertheless the development of telemedicine has had a positive impact on the quality of healthcare services. The COVID-19 pandemic has undoubtedly affected most European countries' quality of healthcare services.", "doi": "10.3389/fpubh.2022.870314", "pmid": "35646786", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9133554"}], "notes": [], "created": "2022-06-21T17:33:41.928Z", "modified": "2022-06-21T17:33:41.942Z"}, {"entity": "publication", "iuid": "4771805ee90843d9ae54590d2abd7a7b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4771805ee90843d9ae54590d2abd7a7b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4771805ee90843d9ae54590d2abd7a7b"}}, "title": "Barriers and Facilitators to Receiving the COVID-19 Vaccination and Development of Theoretically-Informed Implementation Strategies for the Public: Qualitative Study in Hong Kong.", "authors": [{"family": "Wong", "given": "Charlene Hl", "initials": "CH", "orcid": "0000-0003-2623-5855", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0db6ceb15388473bb3a8c6128aa67716.json"}}, {"family": "Zhong", "given": "Claire Cw", "initials": "CC"}, {"family": "Chung", "given": "Vincent Ch", "initials": "VC"}, {"family": "Nilsen", "given": "Per", "initials": "P"}, {"family": "Wong", "given": "Eliza Ly", "initials": "EL", "orcid": "0000-0001-9983-6219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32f2cac9d18445a7b5de24251c6f6be4.json"}}, {"family": "Yeoh", "given": "Eng-Kiong", "initials": "EK"}], "type": "journal article", "published": "2022-05-12", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "5", "issn-l": null}, "abstract": "enhancing uptake of COVID-19 vaccines is an important tool for managing the pandemic. However, in Hong Kong, the COVID-19 vaccination rate in the general population was unsatisfactory during the early phase of the vaccination program. This two-part study aimed to (i) identify barriers and facilitators to receiving vaccinations, and (ii) develop theoretically-informed implementation strategies for promoting uptake.\n\nin part 1, 45 Hong Kong residents who differed in their willingness to vaccinate (willing (n = 15), were unwilling (n = 15), and were hesitant (n = 15)), were interviewed individually in February 2021. They were invited to express their perceptions of receiving the COVID-19 vaccination. The theoretical domains framework (TDF) was applied to guide the interviews and analyses. Behavioral diagnoses from these findings were then used to develop theoretically-informed implementation strategies in part 2, composed of behavior change techniques (BCTs) informed by the established BCT taxonomy.\n\nin part 1, the five main barriers were (i) concerns on severe and long-term side effects; (ii) low confidence in the safety and effectiveness due to concerns of their accelerated development; (iii) unclear information on logistical arrangements of the vaccination program; (iv) insufficient data on safety and effectiveness; and (v) perceived low protection ability conferred by the vaccines. The five main facilitators included (i) healthcare professionals' recommendations; (ii) news from TV, radio, and newspapers as main sources of trustworthy information; (iii) vaccine-related health education delivered by healthcare professionals; (iv) expectations of resuming to a normal social life; and (v) perceived benefits outweighing risks of mild and short-term side effects.\n\nseven implementation strategies were developed in part 2 based on the results above, namely (i) providing trustworthy vaccine-related information and scaling up the promotion; (ii) encouraging healthcare professionals to recommend vaccinations; (iii) giving incentives; (iv) using social influence approaches; (v) allowing a selection of COVID-19 vaccine brands; (vi) increasing accessibility for vaccinations; and (vii) emphasizing social responsibility.", "doi": "10.3390/vaccines10050764", "pmid": "35632520", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "vaccines10050764"}], "notes": [], "created": "2022-06-21T17:39:57.144Z", "modified": "2022-06-21T17:40:13.283Z"}, {"entity": "publication", "iuid": "1b10339b6f5f442bbbd6b427f97707ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b10339b6f5f442bbbd6b427f97707ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b10339b6f5f442bbbd6b427f97707ff"}}, "title": "A Feasibility Study of a Remotely-Delivered Mindfulness-Based Training for Adolescents During the COVID-19 Pandemic.", "authors": [{"family": "Tymofiyeva", "given": "Olga", "initials": "O"}, {"family": "Hu", "given": "Melody Y", "initials": "MY"}, {"family": "Sipes", "given": "Benjamin S", "initials": "BS"}, {"family": "Jakary", "given": "Angela", "initials": "A"}, {"family": "Glidden", "given": "David V", "initials": "DV"}, {"family": "Jariwala", "given": "Namasvi", "initials": "N"}, {"family": "Bhandari", "given": "Sarina", "initials": "S"}, {"family": "Parks", "given": "Kendall C", "initials": "KC"}, {"family": "Nguyen", "given": "Ca", "initials": "C"}, {"family": "Henje", "given": "Eva", "initials": "E"}, {"family": "Yang", "given": "Tony T", "initials": "TT"}], "type": "journal article", "published": "2022-05-12", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "13", "pages": "838694", "issn-l": "1664-0640"}, "abstract": "Social distancing, home confinement, economic challenges, and COVID-19-related illness and deaths during the COVID-19 pandemic can significantly affect mental health in youth. One promising approach to reduce anxiety and depression in adolescents is the neuroscience-based mindfulness intervention Training for Awareness, Resilience, and Action (TARA). The objective of this individually randomized waitlist-controlled trial (RCT) was (1) to test the feasibility of TARA, delivered partially over Zoom, and (2) to assess changes in the emotional wellbeing in healthy adolescents between the ages of 14-18 years old during the COVID-19 pandemic.\n\nTwenty-one healthy adolescents were randomized to the TARA intervention or to the waitlist control group in February 2020, just before the start of the pandemic. The TARA group intervention was delivered in person for the first five sessions and remotely over Zoom for the remaining seven sessions due to the pandemic. The participants' acceptability of TARA was assessed weekly using the Child Session Rating Scale (CSRS). The primary outcome was the emotional wellbeing measured using emotional symptoms subscale of the Strengths and Difficulties Questionnaire (SDQ) pre/post-TARA. We also explored weekly changes in TARA participants' wellbeing using the Child Outcome Rating Scale (CORS).\n\nThe overall session rating in TARA participants improved after the switch to Zoom (Cohen's d = 1.2, p = 0.008). The results of the two-way ANOVA showed no statistically significant difference in the change of the SDQ emotional symptoms during the 12 weeks between the TARA group and waitlist-control group (timepoint \u00d7 group interaction: F = 0.77, p = 0.38). The exploratory analysis using the CORS in the TARA participants showed a significant improvement in their functioning over the weeks of training.\n\nOur results support the feasibility of TARA delivered over Zoom. While our primary outcome did not provide support for the improvement of the emotional wellbeing with TARA compared to a passive control group, our exploratory analysis in the intervention group indicated an improved functioning over the weeks of TARA training. The important general positive impact of this study lies in the possibility of offering a neuroscience-based mindfulness intervention remotely to youth living in remote areas and for all youth during pandemic times.", "doi": "10.3389/fpsyt.2022.838694", "pmid": "35633797", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9133427"}], "notes": [], "created": "2022-06-21T17:38:49.218Z", "modified": "2022-06-21T17:39:01.924Z"}, {"entity": "publication", "iuid": "588e28d247da46e8a413f4f2f7380555", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/588e28d247da46e8a413f4f2f7380555.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/588e28d247da46e8a413f4f2f7380555"}}, "title": "Comparison of years of life lost to 1,565 suicides versus 10,650 COVID-19 deaths in 2020 in Sweden: four times more years of life lost per suicide than per COVID-19 death.", "authors": [{"family": "Ljung", "given": "Rickard", "initials": "R", "orcid": "0000-0002-0654-4530", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ba40c2b98b1442192811ba44ffbf967.json"}}, {"family": "Gr\u00fcnewald", "given": "Maria", "initials": "M", "orcid": "0000-0002-9280-8140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c1e75524a543e6a9f6177f8d7791e2.json"}}, {"family": "Sundstr\u00f6m", "given": "Anders", "initials": "A", "orcid": "0000-0003-2337-3371", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5acbd5b816884f06807b23bd3e2e6cad.json"}}, {"family": "Sundbom", "given": "Lena Thunander", "initials": "LT"}, {"family": "Zethelius", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-1738-0834", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed68e20a415f43d4882fdb44c2e4ee21.json"}}], "type": "journal article", "published": "2022-05-11", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "volume": "127", "issn-l": "0300-9734"}, "abstract": "The burden of disease from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is large; however, suicide affects the population year after year. From a public health perspective, it is important to not neglect contributors to the total burden of disease. The aim of this paper is to compare years of life lost (YLL) to suicide with those lost to coronavirus disease 2019 (COVID-19).\n\nA nationwide cohort study in 2020, in Sweden. YLL was measured as the sex- and age-specific remaining life expectancy at the time of the person's death based on the death risks that pertained to the Swedish population in 2019. YLL to suicide was compared to YLL to COVID-19 and presented by sex and age groups. Suicide deaths in 2020 were estimated as the annual average of suicides in 2015-2019.\n\nAnnual average of suicide was 1,565, whereof 1,076 (68.8%) men and 489 (31.2%) women. In 2020, 10,650 persons died of COVID-19, whereof 5,681 (53.3%) men and 4,969 (46.7%) women. Estimated total YLL to suicide and COVID-19 in 2020 was 53,237 and 90,116, respectively. The COVID-19 YLL to suicide YLL ratio in 2020 was 1.69 (90,116/53,237). Men accounted for 67.1% of suicide YLL and of 56.4% of COVID-19 YLL. Those 44 years or younger accounted for 60.3% of suicide YLL and 3.9% of COVID-19 YLL. Those 75 years and older accounted for 2.9% of suicide YLL and 60.9% of COVID-19 YLL. On average, each suicide generates 34 YLL (53,237/1,565), and each COVID-19 death generates 8.5 YLL (90,116/10,650).\n\nYLL to suicide affects Sweden year after year, foremost attributable to the younger age groups, whereas YLL to COVID-19 is foremost attributable to the elderly. On average, each suicide generates four times more YLL than a COVID-19 death. Enormous efforts and resources have been put on tackling the pandemic, and without these, the burden would probably have been much larger. However, from a public health perspective, it is important to not neglect other contributors to the total burden of disease where national efforts also may have an impact.", "doi": "10.48101/ujms.v127.8533", "pmid": "35722184", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC9169542"}, {"db": "pii", "key": "8533"}], "notes": [], "created": "2022-06-20T18:04:55.929Z", "modified": "2023-01-13T13:40:05.469Z"}, {"entity": "publication", "iuid": "6f6f1f88f28e45819836de1ae35e3526", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f6f1f88f28e45819836de1ae35e3526.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f6f1f88f28e45819836de1ae35e3526"}}, "title": "Can diffusion tensor imaging (DTI) outperform standard magnetic resonance imaging (MRI) investigations in post-COVID-19 autoimmune encephalitis?", "authors": [{"family": "Latini", "given": "Francesco", "initials": "F", "orcid": "0000-0002-4702-526X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30e6260671fb44f4b80218f9acc037fd.json"}}, {"family": "Fahlstr\u00f6m", "given": "Markus", "initials": "M", "orcid": "0000-0002-2502-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce71adf67a984cf6aa8ec4a32cf1d664.json"}}, {"family": "F\u00e4llmar", "given": "David", "initials": "D", "orcid": "0000-0001-5615-2036", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08e1206ab94a43788a7fc641ee13407c.json"}}, {"family": "Marklund", "given": "Niklas", "initials": "N", "orcid": "0000-0002-9797-5626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b0d761a3f60485587650286412498b9.json"}}, {"family": "Cunningham", "given": "Janet L", "initials": "JL", "orcid": "0000-0001-7876-7779", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2f65143e6e34510a93df76eb96d0d7f.json"}}, {"family": "Feresiadou", "given": "Amalia", "initials": "A"}], "type": "journal article", "published": "2022-05-10", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "volume": "127", "issn-l": "0300-9734"}, "abstract": "Neurological and psychiatric manifestations related to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection are widely recognised. Standard magnetic resonance imaging (MRI) investigations are normal in 40-80% of symptomatic patients, eventually delaying appropriate treatment when MRI is unrevealing any structural changes. The aim of this study is to investigate white matter abnormalities during an early stage of post-COVID-19 (coronavirus disease 2019) encephalitis while conventional MRI was normal.\n\nA patient with post-COVID-19 autoimmune encephalitis was investigated by serial MRIs and diffusion tensor imaging (DTI). Ten healthy control individuals (HC) were utilised as a control group for the DTI analysis. Major projection, commissural and association white matter pathways were reconstructed, and multiple diffusion parameters were analysed and then compared to the HC average using a z-test for serial examinations.\n\nEleven days after the onset of neurological symptoms, DTI revealed early white matter changes, compared with HC, when standard MRI was normal. On day 68, DTI showed multiple white matter lesions compared with HC, visible at this time also by the MRI images, indicating inflammatory changes in different association and projection white matter pathways.\n\nWe confirm a limitation in the sensitivity of conventional MRI at the acute setting of post-COVID-19 autoimmune encephalitis. A complementary DTI investigation could be a valuable diagnostic tool in early therapeutic decisions concerning COVID-19-related neurological symptoms.", "doi": "10.48101/ujms.v127.8562", "pmid": "35722186", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "8562"}, {"db": "pmc", "key": "PMC9169543"}], "notes": [], "created": "2022-06-20T18:04:34.750Z", "modified": "2022-08-17T12:45:48.904Z"}, {"entity": "publication", "iuid": "24b14ce13196447b8ec446d4ed60d709", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24b14ce13196447b8ec446d4ed60d709.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24b14ce13196447b8ec446d4ed60d709"}}, "title": "Viral Antigen and Inflammatory Biomarkers in Cerebrospinal Fluid in Patients With COVID-19 Infection and Neurologic Symptoms Compared With Control Participants Without Infection or Neurologic Symptoms.", "authors": [{"family": "Ed\u00e9n", "given": "Arvid", "initials": "A"}, {"family": "Grahn", "given": "Anna", "initials": "A"}, {"family": "Bremell", "given": "Daniel", "initials": "D"}, {"family": "Aghvanyan", "given": "Anahit", "initials": "A"}, {"family": "Bathala", "given": "Pradeepthi", "initials": "P"}, {"family": "Fuchs", "given": "Dietmar", "initials": "D"}, {"family": "Gostner", "given": "Johanna", "initials": "J"}, {"family": "Hagberg", "given": "Lars", "initials": "L"}, {"family": "Kanberg", "given": "Nelly", "initials": "N"}, {"family": "Kanjananimmanont", "given": "Sunsanee", "initials": "S"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Misaghian", "given": "Salvia", "initials": "S"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Sch\u00f6ll", "given": "Michael", "initials": "M"}, {"family": "Sigal", "given": "George", "initials": "G"}, {"family": "Stentoft", "given": "Erika", "initials": "E"}, {"family": "Studahl", "given": "Marie", "initials": "M"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Wang", "given": "Mingyue", "initials": "M"}, {"family": "Stengelin", "given": "Martin", "initials": "M"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2022-05-02", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "volume": "5", "issue": "5", "pages": "e2213253", "issn-l": null}, "abstract": "Neurologic symptoms are common in COVID-19, but the central nervous system (CNS) pathogenesis is unclear, and viral RNA is rarely detected in cerebrospinal fluid (CSF).\n\nTo measure viral antigen and inflammatory biomarkers in CSF in relation to neurologic symptoms and disease severity.\n\nThis cross-sectional study was performed from March 1, 2020, to June 30, 2021, in patients 18 years or older who were admitted to Sahlgrenska University Hospital, Gothenburg, Sweden, with COVID-19. All patients had CSF samples taken because of neurologic symptoms or within a study protocol. Healthy volunteer and prepandemic control groups were included.\n\nSARS-CoV-2 infection.\n\nOutcomes included CSF SARS-CoV-2 nucleocapsid antigen (N-Ag) using an ultrasensitive antigen capture immunoassay platform and CSF biomarkers of immune activation (neopterin, \u03b22-microglobulin, and cytokines) and neuronal injury (neurofilament light protein [NfL]).\n\nForty-four patients (median [IQR] age, 57 [48-69] years; 30 [68%] male; 26 with moderate COVID-19 and 18 with severe COVID-19 based on the World Health Organization Clinical Progression Scale), 10 healthy controls (median [IQR] age, 58 [54-60] years; 5 [50%] male), and 41 patient controls (COVID negative without evidence of CNS infection) (median [IQR] age, 59 [49-70] years; 19 [46%] male) were included in the study. Twenty-one patients were neuroasymptomatic and 23 were neurosymptomatic (21 with encephalopathy). In 31 of 35 patients for whom data were available (89%), CSF N-Ag was detected; viral RNA test results were negative in all. Nucleocapsid antigen was significantly correlated with CSF neopterin (r = 0.38; P = .03) and interferon \u03b3 (r = 0.42; P = .01). No differences in CSF N-Ag concentrations were found between patient groups. Patients had markedly increased CSF neopterin, \u03b22-microglobulin, interleukin (IL) 2, IL-6, IL-10, and tumor necrosis factor \u03b1 compared with controls. Neurosymptomatic patients had significantly higher median (IQR) CSF interferon \u03b3 (86 [47-172] vs 21 [17-81] fg/mL; P = .03) and had a significantly higher inflammatory biomarker profile using principal component analysis compared with neuroasymptomatic patients (0.54; 95% CI, 0.03-1.05; P = .04). Age-adjusted median (IQR) CSF NfL concentrations were higher in patients compared with controls (960 [673-1307] vs 618 [489-786] ng/L; P = .002). No differences were seen in any CSF biomarkers in moderate compared with severe disease.\n\nIn this study of Swedish adults with COVID-19 infection and neurologic symptoms, compared with control participants, viral antigen was detectable in CSF and correlated with CNS immune activation. Patients with COVID-19 had signs of neuroaxonal injury, and neurosymptomatic patients had a more marked inflammatory profile that could not be attributed to differences in COVID-19 severity. These results highlight the clinical relevance of neurologic symptoms and suggest that viral components can contribute to CNS immune responses without direct viral invasion.", "doi": "10.1001/jamanetworkopen.2022.13253", "pmid": "35604688", "labels": {"Category: Biochemistry": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9127556"}, {"db": "pii", "key": "2792536"}], "notes": [], "created": "2022-06-21T17:54:22.642Z", "modified": "2023-06-19T14:45:22.640Z"}, {"entity": "publication", "iuid": "3739638ad7c44737924091555557a402", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3739638ad7c44737924091555557a402.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3739638ad7c44737924091555557a402"}}, "title": "Severe acute respiratory syndrome coronavirus 2 can be detected in exhaled aerosol sampled during a few minutes of breathing or coughing.", "authors": [{"family": "Viklund", "given": "Emilia", "initials": "E", "orcid": "0000-0003-4453-4680", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/332056bb6e88414d9f72c513b31c7959.json"}}, {"family": "Kokelj", "given": "Spela", "initials": "S"}, {"family": "Larsson", "given": "Per", "initials": "P"}, {"family": "Nord\u00e9n", "given": "Rickard", "initials": "R"}, {"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Beck", "given": "Olof", "initials": "O"}, {"family": "Westin", "given": "Johan", "initials": "J"}, {"family": "Olin", "given": "Anna-Carin", "initials": "AC"}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "Influenza Other Respir Viruses", "issn": "1750-2659", "volume": "16", "issue": "3", "pages": "402-410", "issn-l": null}, "abstract": "The knowledge on the concentration of viral particles in exhaled breath is limited. The aim of this study was to explore if severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be detected in aerosol from subjects with the coronavirus disease 2019 (COVID-19) during various types of breathing and coughing and how infection with SARS-CoV-2 may influence the number and size of exhaled aerosol particles.\n\nWe counted and collected endogenous particles in exhaled breath in subjects with COVID-19 disease by two different impaction-based methods, during 20 normal breaths, 10 airway opening breaths, and three coughs, respectively. Breath samples were analyzed with reverse transcription real-time polymerase chain reaction (RT-PCR).\n\nDetection of RNA in aerosol was possible in 10 out of 25 subjects. Presence of virus RNA in aerosol was mainly found in cough samples (n = 8), but also in airway opening breaths (n = 3) and in normal breaths (n = 4), with no overlap between the methods. No association between viral load in aerosol and number exhaled particles <5 \u03bcm was found. Subjects with COVID-19 exhaled less particles than healthy controls during normal breathing and airway opening breaths (all P < 0.05), but not during cough.\n\nSARS-CoV-2 RNA can be detected in exhaled aerosol, sampled during a limited number of breathing and coughing procedures. Detection in aerosol seemed independent of viral load in the upper airway swab as well as of the exhaled number of particles. The infectious potential of the amount of virus detected in aerosol needs to be further explored.", "doi": "10.1111/irv.12964", "pmid": "35037404", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8983906"}], "notes": [], "created": "2022-01-27T07:38:28.676Z", "modified": "2023-06-19T14:19:39.990Z"}, {"entity": "publication", "iuid": "a25e4faab1cd435db55f17485fb41713", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a25e4faab1cd435db55f17485fb41713.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a25e4faab1cd435db55f17485fb41713"}}, "title": "Potential neurological manifestations of COVID-19: a narrative review.", "authors": [{"family": "Pergolizzi", "given": "Joseph V", "initials": "JV", "orcid": "0000-0001-5658-1471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b411beeaa47641bca832e58b7c6a9a69.json"}}, {"family": "Raffa", "given": "Robert B", "initials": "RB", "orcid": "0000-0002-1456-4451", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040955e0221f405494e8870d61dc0378.json"}}, {"family": "Varrassi", "given": "Giustino", "initials": "G", "orcid": "0000-0002-3822-2923", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c88c160784934b09ae6e4d0303fc71b7.json"}}, {"family": "Magnusson", "given": "Peter", "initials": "P", "orcid": "0000-0001-7906-7782", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9484ae1472fe43b39127b01810ffff33.json"}}, {"family": "LeQuang", "given": "Jo Ann", "initials": "JA", "orcid": "0000-0003-4794-0318", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f96aac587798429da2324c43ad9813fa.json"}}, {"family": "Paladini", "given": "Antonella", "initials": "A", "orcid": "0000-0002-1219-9315", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/410a15dde4a84c92ab7c5700879accd8.json"}}, {"family": "Taylor", "given": "Robert", "initials": "R", "orcid": "0000-0001-5971-361X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21635cc313974dbabc0baaa7ac95f6f8.json"}}, {"family": "Wollmuth", "given": "Charles", "initials": "C"}, {"family": "Breve", "given": "Frank", "initials": "F"}, {"family": "Chopra", "given": "Maninder", "initials": "M"}, {"family": "Nalamasu", "given": "Rohit", "initials": "R"}, {"family": "Christo", "given": "Paul J", "initials": "PJ"}, {"family": "NEMA Research Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "Postgrad Med", "issn": "1941-9260", "volume": "134", "issue": "4", "pages": "395-405", "issn-l": "0032-5481"}, "abstract": "Neurological manifestations are increasingly reported in a subset of COVID-19 patients. Previous infections related to coronaviruses, namely Severe Acute Respiratory Syndrome (SARS) and Middle Eastern Respiratory Syndrome (MERS) also appeared to have neurological effects on some patients. The viruses associated with COVID-19 like that of SARS enters the body via the ACE-2 receptors in the central nervous system, which causes the body to balance an immune response against potential damage to nonrenewable cells. A few rare cases of neurological sequelae of SARS and MERS have been reported. A growing body of evidence is accumulating that COVID-19, particularly in severe cases, may have neurological consequences although respiratory symptoms nearly always develop prior to neurological ones. Patients with preexisting neurological conditions may be at elevated risk for COVID-19-associated neurological symptoms. Neurological reports in COVID-19 patients have described encephalopathy, Guillain-Barr\u00e9 syndrome, myopathy, neuromuscular disorders, encephalitis, cephalgia, delirium, critical illness polyneuropathy, and others. Treating neurological symptoms can pose clinical challenges as drugs that suppress immune response may be contraindicated in COVID-19 patients. It is possible that in some COVID-19 patients, neurological symptoms are being overlooked or misinterpreted. To date, neurological manifestations of COVID-19 have been described largely within the disease trajectory and the long-term effects of such manifestations remain unknown.", "doi": "10.1080/00325481.2020.1837503", "pmid": "33089707", "labels": {"Category: Social Science & Humanities": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7799377"}], "notes": [], "created": "2020-11-26T12:16:31.652Z", "modified": "2023-01-13T14:45:28.997Z"}, {"entity": "publication", "iuid": "fce5800c723041d8b1c9b8dcc8e7def2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fce5800c723041d8b1c9b8dcc8e7def2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fce5800c723041d8b1c9b8dcc8e7def2"}}, "title": "Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: Update of a living systematic review and meta-analysis.", "authors": [{"family": "Buitrago-Garcia", "given": "Diana", "initials": "D", "orcid": "0000-0001-9761-206X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21246f1ed5d94488a97190a5e92f5488.json"}}, {"family": "Ipekci", "given": "Aziz Mert", "initials": "AM", "orcid": "0000-0002-0260-9691", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee8671294d5b43f48f76a93236a723be.json"}}, {"family": "Heron", "given": "Leonie", "initials": "L", "orcid": "0000-0002-3820-3343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/873b10a6c024425ebb7c8f6d994ed029.json"}}, {"family": "Imeri", "given": "Hira", "initials": "H", "orcid": "0000-0002-0412-1649", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f82db58c6c3e4bf48102085c1e24bd92.json"}}, {"family": "Araujo-Chaveron", "given": "Lucia", "initials": "L", "orcid": "0000-0002-2110-6088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54a422a247ea4393a3d7383d849f4e18.json"}}, {"family": "Arevalo-Rodriguez", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-7326-4504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28523e3462094df0ad816c3ca1b3cd3d.json"}}, {"family": "Ciapponi", "given": "Agust\u00edn", "initials": "A", "orcid": "0000-0001-5142-6122", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6493e266d9ec4eb0b2b206381516844b.json"}}, {"family": "Cevik", "given": "Muge", "initials": "M", "orcid": "0000-0003-1133-3874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90cabaf2381c4667aa0d4515fc2f3db2.json"}}, {"family": "Hauser", "given": "Anthony", "initials": "A", "orcid": "0000-0002-7221-1929", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4ad8a25f2854575af40c39f93c4c3ac.json"}}, {"family": "Alam", "given": "Muhammad Irfanul", "initials": "MI", "orcid": "0000-0002-8759-6585", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49edca8da0c3453f834d1fec4dfe3876.json"}}, {"family": "Meili", "given": "Kaspar", "initials": "K", "orcid": "0000-0002-9889-4406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a334f6359cd5436fa748f503c5ac24b6.json"}}, {"family": "Meyerowitz", "given": "Eric A", "initials": "EA", "orcid": "0000-0001-7954-6548", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b77f4eeebd94156bfd8b53716a61050.json"}}, {"family": "Prajapati", "given": "Nirmala", "initials": "N", "orcid": "0000-0001-7518-5968", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b573d28168b452aa168f42889153333.json"}}, {"family": "Qiu", "given": "Xueting", "initials": "X", "orcid": "0000-0001-6810-7304", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5eb2980535d4f9a8f6b8b02714545d0.json"}}, {"family": "Richterman", "given": "Aaron", "initials": "A", "orcid": "0000-0001-7920-7191", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13a2fc1e9cba4e16b79ebe473914d3ef.json"}}, {"family": "Robles-Rodriguez", "given": "William Gildardo", "initials": "WG", "orcid": "0000-0002-8383-6844", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c037505a5854c7cb4cc15f4a2c8505d.json"}}, {"family": "Thapa", "given": "Shabnam", "initials": "S"}, {"family": "Zhelyazkov", "given": "Ivan", "initials": "I", "orcid": "0000-0001-6320-7517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d3019d0c667b4d2a9cfc66e2f8cd1541.json"}}, {"family": "Salanti", "given": "Georgia", "initials": "G", "orcid": "0000-0002-3830-8508", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80f3be926d9c4f1a81d9a5ff4717a432.json"}}, {"family": "Low", "given": "Nicola", "initials": "N", "orcid": "0000-0003-4817-8986", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/acef6c2aaf2c4673be2ffe2e3dc5c17d.json"}}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "PLoS Med", "issn": "1549-1676", "volume": "19", "issue": "5", "pages": "e1003987", "issn-l": "1549-1277"}, "abstract": "Debate about the level of asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection continues. The amount of evidence is increasing and study designs have changed over time. We updated a living systematic review to address 3 questions: (1) Among people who become infected with SARS-CoV-2, what proportion does not experience symptoms at all during their infection? (2) What is the infectiousness of asymptomatic and presymptomatic, compared with symptomatic, SARS-CoV-2 infection? (3) What proportion of SARS-CoV-2 transmission in a population is accounted for by people who are asymptomatic or presymptomatic?\n\nThe protocol was first published on 1 April 2020 and last updated on 18 June 2021. We searched PubMed, Embase, bioRxiv, and medRxiv, aggregated in a database of SARS-CoV-2 literature, most recently on 6 July 2021. Studies of people with PCR-diagnosed SARS-CoV-2, which documented symptom status at the beginning and end of follow-up, or mathematical modelling studies were included. Studies restricted to people already diagnosed, of single individuals or families, or without sufficient follow-up were excluded. One reviewer extracted data and a second verified the extraction, with disagreement resolved by discussion or a third reviewer. Risk of bias in empirical studies was assessed with a bespoke checklist and modelling studies with a published checklist. All data syntheses were done using random effects models. Review question (1): We included 130 studies. Heterogeneity was high so we did not estimate a mean proportion of asymptomatic infections overall (interquartile range (IQR) 14% to 50%, prediction interval 2% to 90%), or in 84 studies based on screening of defined populations (IQR 20% to 65%, prediction interval 4% to 94%). In 46 studies based on contact or outbreak investigations, the summary proportion asymptomatic was 19% (95% confidence interval (CI) 15% to 25%, prediction interval 2% to 70%). (2) The secondary attack rate in contacts of people with asymptomatic infection compared with symptomatic infection was 0.32 (95% CI 0.16 to 0.64, prediction interval 0.11 to 0.95, 8 studies). (3) In 13 modelling studies fit to data, the proportion of all SARS-CoV-2 transmission from presymptomatic individuals was higher than from asymptomatic individuals. Limitations of the evidence include high heterogeneity and high risks of selection and information bias in studies that were not designed to measure persistently asymptomatic infection, and limited information about variants of concern or in people who have been vaccinated.\n\nBased on studies published up to July 2021, most SARS-CoV-2 infections were not persistently asymptomatic, and asymptomatic infections were less infectious than symptomatic infections. Summary estimates from meta-analysis may be misleading when variability between studies is extreme and prediction intervals should be presented. Future studies should determine the asymptomatic proportion of SARS-CoV-2 infections caused by variants of concern and in people with immunity following vaccination or previous infection. Without prospective longitudinal studies with methods that minimise selection and measurement biases, further updates with the study types included in this living systematic review are unlikely to be able to provide a reliable summary estimate of the proportion of asymptomatic infections caused by SARS-CoV-2.\n\nOpen Science Framework (https://osf.io/9ewys/).", "doi": "10.1371/journal.pmed.1003987", "pmid": "35617363", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "PMEDICINE-D-22-00260"}], "notes": [], "created": "2022-06-21T17:47:28.227Z", "modified": "2022-06-21T17:47:28.928Z"}, {"entity": "publication", "iuid": "3a73765806e14038a7f427e6cfaeea2e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a73765806e14038a7f427e6cfaeea2e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a73765806e14038a7f427e6cfaeea2e"}}, "title": "Moral Distress Among Operating Room Personnel During the COVID-19 Pandemic: A Qualitative Study", "authors": [{"family": "Fagerdahl", "given": "Ann Mari", "initials": "AM", "orcid": "0000-0002-9170-581X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ade5aac0a60a4ad1b19ccef36320e13e.json"}}, {"family": "Torbj\u00f6rnsson", "given": "Eva", "initials": "E"}, {"family": "Gustavsson", "given": "Martina", "initials": "M", "orcid": "0000-0002-6193-6289", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/658c2b521a9142d494ee474d9944d5b7.json"}}, {"family": "\u00c4lg\u00e5", "given": "Andreas", "initials": "A"}], "type": "journal-article", "published": "2022-05-00", "journal": {"title": "Journal of Surgical Research", "issn": "0022-4804", "volume": "273", "pages": "110-118", "issn-l": null}, "abstract": "The ongoing COVID-19 pandemic has necessitated the reallocation of healthcare resources, and a minimization of elective activities. Healthcare personnel involved in COVID-19 care have been negatively affected by the associated excess stress. The existing COVID-19 research has focused on the experiences among healthcare personnel in general, and not particularly on the operating room team members, who have often been relocated to overburdened workplaces. Therefore, we aimed to explore the experiences in this particular group.\n\nThis study has a qualitative inductive design based on interviews with a strategic sample of 12 operating room team members: surgeons, anesthesiologist, specialist nurses, and nurse assistants. The interviews were analyzed using content analysis.\n\nThree themes were identified: \"Feeling safe in the familiar and anxiety in the unknown\", \"To be the ones left behind\", and \"The possibility for recuperation in a seemingly everlasting situation\". The participants described working hard, although their efforts were experienced as not enough according to their moral ideals. We interpreted this as feelings and signs of moral distress, a commonly described concept in previous studies during the COVID-19 pandemic, and a risk for burn out.\n\nThe operating room team members emphasized the negative stress of being in the unknown, performing work tasks in an unfamiliar place and situation, and experiencing conflicting feelings of relief and guilt. Organizational strategies toward a functional leadership and support should be emphasized. Such strategies might reduce the risk of psychological consequences such as burn out.", "doi": "10.1016/j.jss.2021.12.011", "pmid": "35033820", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0022-4804(21)00740-X"}, {"db": "pmc", "key": "PMC8692083"}], "notes": [], "created": "2022-01-27T07:48:44.330Z", "modified": "2022-06-21T18:15:28.541Z"}, {"entity": "publication", "iuid": "e714e24b70654a99a7bda77f7eb68634", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e714e24b70654a99a7bda77f7eb68634.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e714e24b70654a99a7bda77f7eb68634"}}, "title": "Envisioning sustainable and equitable World Health Assemblies.", "authors": [{"family": "Khorsand", "given": "Parnian", "initials": "P", "orcid": "0000-0002-5347-1629", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5bcdb597d56c4e2a9141a03c59902375.json"}}, {"family": "Chowdhury", "given": "Maisoon", "initials": "M"}, {"family": "Wyns", "given": "Arthur", "initials": "A"}, {"family": "Velin", "given": "Lotta", "initials": "L", "orcid": "0000-0002-1929-6011", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c5b0a7da8a4eb19b92be09bbbef9b1.json"}}, {"family": "Wangari", "given": "Marie-Claire", "initials": "MC", "orcid": "0000-0002-4529-8133", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31a1675605154adda9fef1e2b842a291.json"}}, {"family": "Cipriano", "given": "Gabriela", "initials": "G"}, {"family": "El Omrani", "given": "Omnia", "initials": "O", "orcid": "0000-0002-1655-1195", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4eaa1ea11e884f49a9c60f7f9cd2bc74.json"}}, {"family": "Patil", "given": "Poorvaprabha", "initials": "P"}, {"family": "van Daalen", "given": "Kim", "initials": "K"}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "7", "issue": "5", "issn-l": "2059-7908"}, "abstract": null, "doi": "10.1136/bmjgh-2022-009231", "pmid": "35613838", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2022-009231"}], "notes": [], "created": "2022-06-21T17:49:52.561Z", "modified": "2022-06-21T17:50:07.987Z"}, {"entity": "publication", "iuid": "3d935e59859c4024845fca7dd4df8caa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3d935e59859c4024845fca7dd4df8caa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3d935e59859c4024845fca7dd4df8caa"}}, "title": "Decidual stromal cell therapy for generalized lymphadenopathy as a special clinical manifestation of COVID-19 infection: A case report.", "authors": [{"family": "Pirsalehi", "given": "Ali", "initials": "A"}, {"family": "Soleimani", "given": "Masoud", "initials": "M"}, {"family": "Hajifathali", "given": "Abbas", "initials": "A"}, {"family": "Sadeghi", "given": "Behnam", "initials": "B"}, {"family": "Farhadihosseinabadi", "given": "Behrouz", "initials": "B"}, {"family": "Akhlaghi", "given": "Sedigheh Sadat", "initials": "SS"}, {"family": "Roshandel", "given": "Elham", "initials": "E", "orcid": "0000-0002-3698-4342", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e62f2dd66ca0485091e82ae8562d1505.json"}}], "type": "case reports", "published": "2022-05-00", "journal": {"title": "Clin Case Rep", "issn": "2050-0904", "volume": "10", "issue": "5", "pages": "e05851", "issn-l": null}, "abstract": "We are going through the greatest global health crisis of the last decades, the coronavirus disease 2019 (COVID-19) pandemic. It may cause morbidity and mortality in some cases, and there is no therapeutic approach with reproducible and favorable outcomes. As clinical manifestations differ from patient to patient, any report regarding clinical symptoms has been beneficial for early detection and treatment. Due to the immunomodulatory effect of mesenchymal stem cells (MSCs), MSCs-based therapy has been approved to be one of the therapeutic strategies for COVID-19 management. For the first time in the literature, we reported generalized lymphadenopathy with fever and no sign of respiratory distress in a 16-year-old patient with confirmed COVID-19 infection as the main clinical signs. We also introduce decidual stromal cells as a potential immunomodulatory treatment for COVID-19-infected patients.", "doi": "10.1002/ccr3.5851", "pmid": "35600010", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "CCR35851"}, {"db": "pmc", "key": "PMC9109646"}], "notes": [], "created": "2022-06-21T17:57:22.435Z", "modified": "2022-06-21T17:57:41.697Z"}, {"entity": "publication", "iuid": "8826996b9bfa4f1cb9689c5f1a4bd6b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8826996b9bfa4f1cb9689c5f1a4bd6b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8826996b9bfa4f1cb9689c5f1a4bd6b1"}}, "title": "Critical Influenza and COVID-19-A Comparative Nationwide Case-Control Study.", "authors": [{"family": "Larsson", "given": "Emma", "initials": "E"}, {"family": "Eriksson", "given": "Jesper", "initials": "J"}, {"family": "Eriksson", "given": "Mikael", "initials": "M"}, {"family": "Oldner", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "Crit Care Explor", "issn": "2639-8028", "volume": "4", "issue": "5", "pages": "e0705", "issn-l": null}, "abstract": "Refined knowledge of risk factors for critical influenza and COVID-19 may lead to improved understanding of pathophysiology and better pandemic preparedness.\n\nTo compare risk-factor profiles of patients admitted to intensive care with critical influenza and COVID-19.\n\nA nationwide retrospective matched case-control study, including all adults admitted to an ICU in Sweden with influenza or COVID-19 between 2014 and September 2020 and a matched control population (ratio 1:5, patients:controls).\n\nAdmission to an ICU. The study included 1,873 influenza and 2,567 COVID-19 ICU patients, and 9,365 and 12,835 controls, respectively, matched on sex, age, and geographical region. Influenza patients were older and less likely male, and carried a larger burden of comorbidity and a higher Simplified Acute Physiology Score III score, whereas short-term mortalities were similar when compared to COVID-19 patients. The risk-factor profiles at ICU admission were largely comparable including socioeconomic, psychiatric, and several somatic variables. Hypertension was a strong risk factor in critical COVID-19 patients compared with influenza. Nonglucocorticoid immunosuppressive therapy was associated with critical influenza but not COVID-19. Premorbid medication with statins and renin-angiotensin-aldosterone system inhibitors reduced the risk for both conditions, the opposite was a seen for glucocorticoid medication. Notably, medication with betablockers, oral anticoagulation, and platelet inhibitors reduced the risk of critical COVID-19 but not influenza.\n\nThe risk-factor profiles for critical influenza and COVID-19 were largely comparable; however, some important differences were noted. Hypertension was a stronger risk factor for developing critical COVID-19, whereas the use of betablockers, oral anticoagulants, and platelet inhibitors all reduced the risk of ICU admission for COVID-19 but not influenza. Findings possibly reflected differences in pathophysiological mechanisms between these conditions.", "doi": "10.1097/CCE.0000000000000705", "pmid": "35620773", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9113210"}], "notes": [], "created": "2022-06-21T17:46:41.918Z", "modified": "2022-06-21T17:46:54.296Z"}, {"entity": "publication", "iuid": "07b3875cd4054292815a8c4612d07501", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07b3875cd4054292815a8c4612d07501.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07b3875cd4054292815a8c4612d07501"}}, "title": "Convulsions in children with COVID-19 during the Omicron wave.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF", "orcid": "0000-0003-1024-5602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1d5e45881a7469ca20a0eb360d891cc.json"}}], "type": "case reports", "published": "2022-05-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": "111", "issue": "5", "pages": "1023-1026"}, "abstract": "Most children with COVID-19 have mild symptoms, but data on the Omicron variant are rare. This paper describes unexpected cases with convulsions during 1 week in January 2022.\n\nFour children with COVID-19 were admitted with convulsions to the paediatric department in \u00d6rebro, Sweden, when Omicron accounted for more than 98% of the country's COVID-19 cases. Three children tested positive for the virus, and one had clinical COVID-19. I was able to contact the parents of three boys, who gave consent for these case studies.\n\nTwo boys aged 3 and 21 months tested positive for the virus and a 14-year-old boy tested negative, but had a cold and family members who had tested positive. The teenager had a history of urinary tract infections, but the younger boys had no earlier comorbidities. None had a history of epilepsy or febrile convulsions. The younger children had a fever and the teenager had upper respiratory symptoms. The 3-month-old child had repeated convulsions for several hours, the 21-month-old had continuous convulsions for 15-20 min, and the teenager had a convulsion for 30-60 s, followed by uncharacteristic aggression.\n\nConvulsions may be a sign of the Omicron variant in children with COVID-19.", "doi": "10.1111/apa.16276", "pmid": "35098577", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Omicron VoC": null}, "xrefs": [{"db": "pmc", "key": "PMC9303202"}], "notes": [], "created": "2022-02-06T16:55:21.106Z", "modified": "2023-07-13T11:26:25.599Z"}, {"entity": "publication", "iuid": "4401467d26b944ba942c0ca2330ebac6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4401467d26b944ba942c0ca2330ebac6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4401467d26b944ba942c0ca2330ebac6"}}, "title": "Clinically observed deletions in SARS-CoV-2 Nsp1 affect its stability and ability to inhibit translation.", "authors": [{"family": "Kumar", "given": "Pravin", "initials": "P"}, {"family": "Schexnaydre", "given": "Erin", "initials": "E"}, {"family": "Rafie", "given": "Karim", "initials": "K"}, {"family": "Kurata", "given": "Tatsuaki", "initials": "T"}, {"family": "Terenin", "given": "Ilya", "initials": "I"}, {"family": "Hauryliuk", "given": "Vasili", "initials": "V", "orcid": "0000-0003-2389-5057", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1c92042b0bf4268a03534211e245236.json"}}, {"family": "Carlson", "given": "Lars-Anders", "initials": "LA", "orcid": "0000-0003-2342-6488", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79dd613daf254b33af16fafe01bf767c.json"}}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "FEBS Lett", "issn": "1873-3468", "volume": "596", "issue": "9", "pages": "1203-1213", "issn-l": null}, "abstract": "Nonstructural protein 1 (Nsp1) of SARS-CoV-2 inhibits host cell translation through an interaction between its C-terminal domain and the 40S ribosome. The N-terminal domain (NTD) of Nsp1 is a target of recurring deletions, some of which are associated with altered COVID-19 disease progression. Here, we characterize the efficiency of translational inhibition by clinically observed Nsp1 deletion variants. We show that a frequent deletion of residues 79-89 severely reduces the ability of Nsp1 to inhibit translation while not abrogating Nsp1 binding to the 40S. Notably, while the SARS-CoV-2 5' untranslated region enhances translation of mRNA, it does not protect from Nsp1-mediated inhibition. Finally, thermal stability measurements and structure predictions reveal a correlation between stability of the NTD and the efficiency of translation inhibition.", "doi": "10.1002/1873-3468.14354", "pmid": "35434785", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9081967"}], "notes": [], "created": "2022-10-13T12:59:32.403Z", "modified": "2022-10-13T12:59:32.530Z"}, {"entity": "publication", "iuid": "36edc1be7141435f9e1be136f7a7c17d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/36edc1be7141435f9e1be136f7a7c17d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/36edc1be7141435f9e1be136f7a7c17d"}}, "title": "Changes in Maternal Substance Use During the COVID-19 Pandemic.", "authors": [{"family": "Joyce", "given": "Kayla M", "initials": "KM"}, {"family": "Cameron", "given": "Emily E", "initials": "EE"}, {"family": "Sulymka", "given": "Julia", "initials": "J"}, {"family": "Protudjer", "given": "Jennifer L P", "initials": "JLP"}, {"family": "Roos", "given": "Leslie E", "initials": "LE"}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "J Stud Alcohol Drugs", "issn": "1938-4114", "volume": "83", "issue": "3", "pages": "352-357", "issn-l": null}, "abstract": "Maternal stress and mental health challenges have increased since the coronavirus disease 2019 (COVID-19) pandemic began. Experts are concerned about elevated substance use given its well-known association with negative emotions, but existing research has not examined substance use among mothers during the COVID-19 pandemic. This is a crucial next step to inform policy and service supports given links between maternal substance use and adverse family experiences.\n\nData were collected online between April 14 and 28, 2020. A total of 508 mothers (mean age = 34.8 years, SD = 5.1) with children 0-8 years old participated via the Parenting During the Pandemic study. Mothers self-reported substance use change and motivations for using substances, as well as mental health symptoms.\n\nOf participating mothers, 54.9% did not change, 39.2% increased, and 5.9% decreased their substance use. Findings indicated that mothers with an anxiety disorder or elevated anxiety symptoms were more likely to report increased substance use during the pandemic. Using substances to cope with anxiety, depression, and boredom was elevated among mothers self-reporting increased substance use during the pandemic versus those reporting no change or a decrease in usage. Using substances to cope with anxiety was a risk factor for increased substance use.\n\nMany mothers have increased their substance use since the onset of the COVID-19 pandemic. Results highlight the need to treat maternal anxiety and the importance of teaching mothers coping strategies, other than using substances, to reduce the incidence of increased substance use among mothers and its negative sequelae.", "doi": null, "pmid": "35590175", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T18:00:17.710Z", "modified": "2022-06-21T18:00:17.751Z"}, {"entity": "publication", "iuid": "2178f25932ef44ab8a94a9230fac5ac3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2178f25932ef44ab8a94a9230fac5ac3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2178f25932ef44ab8a94a9230fac5ac3"}}, "title": "Cardiac dysfunction and mortality in critically ill patients with COVID-19: A Swedish multicentre observational study.", "authors": [{"family": "Holmqvist", "given": "Jacob", "initials": "J"}, {"family": "Beck-Friis", "given": "Josefine", "initials": "J", "orcid": "0000-0003-2400-4092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3f3764c8d95410abc83f9c3cca2eaeb.json"}}, {"family": "Jensen", "given": "Carl", "initials": "C"}, {"family": "Dalla", "given": "Keti", "initials": "K", "orcid": "0000-0001-7367-2500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f1c43bc04bf49a7adc3559aa5deb916.json"}}, {"family": "M\u00e5rdstam", "given": "Simon", "initials": "S"}, {"family": "Christensen", "given": "Jens", "initials": "J"}, {"family": "Nord\u00e9n", "given": "Nina", "initials": "N"}, {"family": "Widing", "given": "Hannes", "initials": "H"}, {"family": "Ros\u00e9n-Wetterholm", "given": "Elin", "initials": "E"}, {"family": "Cavefors", "given": "Oscar", "initials": "O"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Redfors", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Oras", "given": "Jonatan", "initials": "J", "orcid": "0000-0001-8890-6752", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bcac0f5ee544c18ba18e949ce76d121.json"}}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "volume": "66", "issue": "5", "pages": "606-614", "issn-l": "0001-5172"}, "abstract": "The prevalence and importance of cardiac dysfunction in critically ill patients with COVID-19 in Sweden is not yet established. The aim of the study was to assess the prevalence of cardiac dysfunction and elevated pulmonary artery pressure (PAP), and its influence on mortality in patients with COVID-19 in intensive care in Sweden.\n\nThis was a multicentre observational study performed in five intensive care units (ICUs) in Sweden. Patients admitted to participating ICU with COVID-19 were examined with echocardiography within 72 h from admission and again after 4 to 7 days. Cardiac dysfunction was defined as left ventricular (LV) dysfunction (ejection fraction <50% and/or regional hypokinesia) or right ventricular (RV) dysfunction (defined as TAPSE <17 mm or visually assessed moderate/severe RV dysfunction).\n\nWe included 132 patients, of whom 127 (96%) were intubated. Cardiac dysfunction was found in 42 (32%) patients. Most patients had cardiac dysfunction at the first assessment (n = 35) while a few developed cardiac dysfunction later (n = 7) and some changed type of dysfunction (n = 3). LV dysfunction was found in 21 and RV dysfunction in 19 patients, while 5 patients had combined dysfunction. Elevated PAP was found in 34 patients (26%) and was more common in patients with RV dysfunction. RV dysfunction and elevated PAP were independently associated with an increased risk of death (OR 3.98, p = .013 and OR 3.88, p = .007, respectively).\n\nCardiac dysfunction occurs commonly in critically ill patients with COVID-19 in Sweden. RV dysfunction and elevated PAP are associated with an increased risk of death.", "doi": "10.1111/aas.14039", "pmid": "35122232", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9111275"}], "notes": [], "created": "2022-02-06T16:45:14.911Z", "modified": "2023-06-19T14:21:31.581Z"}, {"entity": "publication", "iuid": "7f77851d69024d19b295883953bc730d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f77851d69024d19b295883953bc730d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f77851d69024d19b295883953bc730d"}}, "title": "Acute COVID-19 severity and mental health morbidity trajectories in patient populations of six nations: an observational study.", "authors": [{"family": "Magn\u00fasd\u00f3ttir", "given": "Ingibj\u00f6rg", "initials": "I"}, {"family": "Lovik", "given": "Anik\u00f3", "initials": "A"}, {"family": "Unnarsd\u00f3ttir", "given": "Anna B\u00e1ra", "initials": "AB"}, {"family": "McCartney", "given": "Daniel", "initials": "D"}, {"family": "Ask", "given": "Helga", "initials": "H"}, {"family": "K\u00f5iv", "given": "Kadri", "initials": "K"}, {"family": "Christoffersen", "given": "Lea Arregui Nordahl", "initials": "LAN"}, {"family": "Johnson", "given": "Sverre Urnes", "initials": "SU"}, {"family": "Hauksd\u00f3ttir", "given": "Arna", "initials": "A"}, {"family": "Fawns-Ritchie", "given": "Chloe", "initials": "C"}, {"family": "Helenius", "given": "Dorte", "initials": "D"}, {"family": "Gonz\u00e1lez-Hij\u00f3n", "given": "Juan", "initials": "J"}, {"family": "Lu", "given": "Li", "initials": "L"}, {"family": "Ebrahimi", "given": "Omid V", "initials": "OV"}, {"family": "Hoffart", "given": "Asle", "initials": "A"}, {"family": "Porteous", "given": "David J", "initials": "DJ"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Jakobsd\u00f3ttir", "given": "J\u00f3hanna", "initials": "J"}, {"family": "Lehto", "given": "Kelli", "initials": "K"}, {"family": "Andreassen", "given": "Ole A", "initials": "OA"}, {"family": "Pedersen", "given": "Ole B V", "initials": "OBV"}, {"family": "Aspelund", "given": "Thor", "initials": "T"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur Anna", "initials": "UA"}, {"family": "COVIDMENT Collaboration", "given": "", "initials": ""}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "Lancet Public Health", "issn": "2468-2667", "volume": "7", "issue": "5", "pages": "e406-e416", "issn-l": null}, "abstract": "Long-term mental and physical health consequences of COVID-19 (long COVID) are a persistent public health concern. Little is still known about the long-term mental health of non-hospitalised patients with COVID-19 with varying illness severities. Our aim was to assess the prevalence of adverse mental health symptoms among individuals diagnosed with COVID-19 in the general population by acute infection severity up to 16 months after diagnosis.\n\nThis observational follow-up study included seven prospectively planned cohorts across six countries (Denmark, Estonia, Iceland, Norway, Sweden, and the UK). Participants were recruited from March 27, 2020, to Aug 13, 2021. Individuals aged 18 years or older were eligible to participate. In a cross-sectional analysis, we contrasted symptom prevalence of depression, anxiety, COVID-19-related distress, and poor sleep quality (screened with validated mental health instruments) among individuals with and without a diagnosis of COVID-19 at entry, 0-16 months from diagnosis. In a cohort analysis, we further used repeated measures to estimate the change in mental health symptoms before and after COVID-19 diagnosis.\n\nThe analytical cohort consisted of 247 249 individuals, 9979 (4\u00b70%) of whom were diagnosed with COVID-19 during the study period. Mean follow-up was 5\u00b765 months (SD 4\u00b726). Participants diagnosed with COVID-19 presented overall with a higher prevalence of symptoms of depression (prevalence ratio [PR] 1\u00b718 [95% CI 1\u00b703-1\u00b736]) and poorer sleep quality (1\u00b713 [1\u00b703-1\u00b724]) but not symptoms of anxiety (0\u00b797 [0\u00b791-1\u00b703]) or COVID-19-related distress (1\u00b705 [0\u00b793-1\u00b720]) compared with individuals without a COVID-19 diagnosis. Although the prevalence of depression and COVID-19-related distress attenuated with time, individuals diagnosed with COVID-19 but never bedridden due to their illness were consistently at lower risk of depression (PR 0\u00b783 [95% CI 0\u00b775-0\u00b791]) and anxiety (0\u00b777 [0\u00b763-0\u00b794]) than those not diagnosed with COVID-19, whereas patients who were bedridden for more than 7 days were persistently at higher risk of symptoms of depression (PR 1\u00b761 [95% CI 1\u00b727-2\u00b705]) and anxiety (1\u00b743 [1\u00b726-1\u00b763]) than those not diagnosed throughout the study period.\n\nSevere acute COVID-19 illness-indicated by extended time bedridden-is associated with long-term mental morbidity among recovering individuals in the general population. These findings call for increased vigilance of adverse mental health development among patients with a severe acute disease phase of COVID-19.\n\nNordforsk, Horizon2020, Wellcome Trust, and Estonian Research Council.", "doi": "10.1016/S2468-2667(22)00042-1", "pmid": "35298894", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8920517"}, {"db": "pii", "key": "S2468-2667(22)00042-1"}], "notes": [], "created": "2023-02-13T18:38:15.520Z", "modified": "2023-02-13T18:38:15.523Z"}, {"entity": "publication", "iuid": "63501e894e164b0bbdb771e6aed8e8cd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63501e894e164b0bbdb771e6aed8e8cd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63501e894e164b0bbdb771e6aed8e8cd"}}, "title": "Changes in dementia diagnoses in Sweden during the COVID-19 pandemic.", "authors": [{"family": "Axenhus", "given": "Michael", "initials": "M"}, {"family": "Schedin-Weiss", "given": "Sophia", "initials": "S"}, {"family": "Tjernberg", "given": "Lars", "initials": "L"}, {"family": "Wimo", "given": "Anders", "initials": "A"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}, {"family": "Bucht", "given": "Gustaf", "initials": "G"}, {"family": "Winblad", "given": "Bengt", "initials": "B"}], "type": "journal article", "published": "2022-04-26", "journal": {"title": "BMC Geriatr", "issn": "1471-2318", "volume": "22", "issue": "1", "pages": "365", "issn-l": null}, "abstract": "The COVID-19 pandemic has caused large disruptions to healthcare systems. Refocus on COVID-19 related care might have contributed to indirect effects on other healthcare areas. Care focused on acute conditions have been negatively affected although research into the effects on chronic and care intensive patient groups such as patients with dementia diseases is lacking. In this study we evaluated dementia diagnosis trends in Sweden during 2015-2020 according to International Classification of Disease version 10 coding of common dementia diseases.\n\nRegional and national statistics in the form of International Classification of Disease version 10 coding, COVID-19 incidence, mortality data, and population census data were collected from the National Institute of Health and Welfare. Logistic regression analysis was performed to identify trends of dementia diagnosis during 2015-2020. Correlation test was performed between COVID-19 incidence, mortality rates, and dementia coding.\n\nDementia diagnosis incidence has been declining since 2015 and further decline was noted in many regions in Sweden during 2020. As COVID-19 incidence increased, fewer cases of dementia were diagnosed, a decrease that differentially impacted women and those who were advanced in age.\n\nDementia diagnosis incidence in Sweden has been on a decline since 2015. The COVID-19 pandemic caused a further larger decline in dementia diagnosis incidence during 2020. COVID-19 incidence, but not mortality, was associated with decrease in dementia diagnosis incidence. There might be a large number of undiagnosed patients with dementia and healthcare reforms should be enacted to address this. Women and elderly are particularly vulnerable groups.", "doi": "10.1186/s12877-022-03070-y", "pmid": "35473668", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9039601"}, {"db": "pii", "key": "10.1186/s12877-022-03070-y"}], "notes": [], "created": "2023-01-13T13:24:16.248Z", "modified": "2023-07-13T11:28:31.916Z"}, {"entity": "publication", "iuid": "07a7aba3e7594af8a3d7070d543d7b60", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07a7aba3e7594af8a3d7070d543d7b60.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07a7aba3e7594af8a3d7070d543d7b60"}}, "title": "Characterization of the Upper Respiratory Bacterial Microbiome in Critically Ill COVID-19 Patients.", "authors": [{"family": "Bai", "given": "Xiangning", "initials": "X"}, {"family": "Narayanan", "given": "Aswathy", "initials": "A"}, {"family": "Skagerberg", "given": "Magdalena", "initials": "M"}, {"family": "Ce\u00f1a-Diez", "given": "Rafael", "initials": "R", "orcid": "0000-0001-9987-395X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dd115af211249249702e843a35ca885.json"}}, {"family": "Giske", "given": "Christian G", "initials": "CG"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2022-04-23", "journal": {"title": "Biomedicines", "issn": "2227-9059", "volume": "10", "issue": "5", "issn-l": null}, "abstract": "The upper respiratory tract (URT) microbiome can contribute to the acquisition and severity of respiratory viral infections. The described associations between URT microbiota and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are limited at microbiota genus level and by the lack of functional interpretation. Our study, therefore, characterized the URT bacterial microbiome at species level and their encoded pathways in patients with COVID-19 and correlated these to clinical outcomes. Whole metagenome sequencing was performed on nasopharyngeal samples from hospitalized patients with critical COVID-19 (n = 37) and SARS-CoV-2-negative individuals (n = 20). Decreased bacterial diversity, a reduction in commensal bacteria, and high abundance of pathogenic bacteria were observed in patients compared to negative controls. Several bacterial species and metabolic pathways were associated with better respiratory status and lower inflammation. Strong correlations were found between species biomarkers and metabolic pathways associated with better clinical outcome, especially Moraxella lincolnii and pathways of vitamin K2 biosynthesis. Our study demonstrates correlations between the URT microbiome and COVID-19 patient outcomes; further studies are warranted to validate these findings and to explore the causal roles of the identified microbiome biomarkers in COVID-19 pathogenesis.", "doi": "10.3390/biomedicines10050982", "pmid": "35625719", "labels": {"Type: Journal article": null, "Category: Health": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "biomedicines10050982"}], "notes": [], "created": "2022-06-21T17:41:02.435Z", "modified": "2022-06-21T17:42:47.714Z"}, {"entity": "publication", "iuid": "0ec5c2cac37d43749d6f318b8a2c95a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ec5c2cac37d43749d6f318b8a2c95a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ec5c2cac37d43749d6f318b8a2c95a0"}}, "title": "Impact of Long COVID on health and quality of life.", "authors": [{"family": "O' Mahony", "given": "Liam", "initials": "L", "orcid": "0000-0003-4705-3583", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff1b8e3e2a0740c2b80dfc33eb95918c.json"}}, {"family": "Buwalda", "given": "Tanja", "initials": "T", "orcid": "0000-0003-1759-1348", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f77991bf89546659fcad40626ce0337.json"}}, {"family": "Blair", "given": "Matthew", "initials": "M"}, {"family": "Forde", "given": "Brian", "initials": "B"}, {"family": "Lunjani", "given": "Nonhlanhla", "initials": "N"}, {"family": "Ambikan", "given": "Anoop", "initials": "A"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U", "orcid": "0000-0002-0844-3338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5c27a627463945d992d74005f8a60d88.json"}}, {"family": "Barrett", "given": "Peter", "initials": "P", "orcid": "0000-0002-9637-9603", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae6be9f9cf2742c1a5ac01083e07d287.json"}}, {"family": "Geary", "given": "Eoin", "initials": "E"}, {"family": "O'Connor", "given": "Nuala", "initials": "N"}, {"family": "Dineen", "given": "Jennifer", "initials": "J"}, {"family": "Clarke", "given": "Gerard", "initials": "G"}, {"family": "Kelleher", "given": "Eric", "initials": "E"}, {"family": "Horgan", "given": "Mary", "initials": "M"}, {"family": "Jackson", "given": "Arthur", "initials": "A"}, {"family": "Sadlier", "given": "Corinna", "initials": "C", "orcid": "0000-0002-8415-2022", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/036863e36b4d4480b10efc5e1cd8a025.json"}}], "type": "journal article", "published": "2022-04-22", "journal": {"title": "HRB Open Res", "issn": "2515-4826", "volume": "5", "pages": "31", "issn-l": null}, "abstract": "Background: The aim of this study was to measure the impact of post-acute sequelae of COVID-19 (PASC) on quality of life, mental health, ability to work and return to baseline health in an Irish cohort. Methods: We invited individuals with symptoms of COVID-19 lasting more than 14 days to participate in an anonymous online questionnaire. Basic demographic data and self-reported symptoms were recorded. Internationally validated instruments including the patient health questionnaire somatic, anxiety and depressive symptom scales (PHQ-SADS), the Patient Health Questionnaire-15 (PHQ-15) and Chadler fatigue scale (CFQ) were used. Results: We analysed responses from 988 participants with self-reported confirmed (diagnostic/antibody positive; 81%) or suspected (diagnostic/antibody negative or untested; 9%) COVID-19. The majority of respondents were female (88%), white (98%), with a median age of 43.0 (range 15 - 88 years old) and a median BMI of 26.0 (range 16 - 60). At the time of completing this survey, 89% of respondents reported that they have not returned to their pre-COVID-19 level of health. The median number of symptoms reported was 8 (range 0 to 33 symptoms), with a median duration of 12 months (range 1 to 20 months) since time of acute infection. A high proportion of PASC patients reported that they have a moderate or severe limitation in their ability to carry out their usual activities, 38% report their ability to work is severely limited and 33% report a moderate, or higher, level of anxiety or depression. Conclusion: The results of this survey of an Irish cohort with PASC are in line with reports from other settings, and we confirm that patients with PASC reported prolonged, multi-system symptoms which can significantly impact quality of life, affect ability to work and cause significant disability. Dedicated multidisciplinary, cross specialty supports are required to improve outcomes of this patient group.", "doi": "10.12688/hrbopenres.13516.1", "pmid": "36101871", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9440374"}, {"db": "figshare", "key": "10.6084/m9.figshare.19364828.v1"}], "notes": [], "created": "2022-10-13T13:30:19.780Z", "modified": "2022-10-13T13:30:19.933Z"}, {"entity": "publication", "iuid": "4b983ed275bb4432b5d9c6b0caa293f5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b983ed275bb4432b5d9c6b0caa293f5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b983ed275bb4432b5d9c6b0caa293f5"}}, "title": "App-based COVID-19 syndromic surveillance and prediction of hospital admissions in COVID Symptom Study Sweden.", "authors": [{"family": "Kennedy", "given": "Beatrice", "initials": "B", "orcid": "0000-0002-0066-4814", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d3a346caa424c4dad653097b2518efb.json"}}, {"family": "Fitipaldi", "given": "Hugo", "initials": "H", "orcid": "0000-0001-5352-2134", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3dc5e2fbac6748eaa733dc8ee1abdfa8.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U"}, {"family": "Maziarz", "given": "Marlena", "initials": "M", "orcid": "0000-0003-1417-6050", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89782e93a17a4b44a89ad63cd80cce7f.json"}}, {"family": "Tsereteli", "given": "Neli", "initials": "N"}, {"family": "Oskolkov", "given": "Nikolay", "initials": "N", "orcid": "0000-0001-5326-8893", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c7eace8c27946a0b98ef5fcba466b0d.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G", "orcid": "0000-0002-3320-2448", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73494da542e8482694f425eb2de5d52d.json"}}, {"family": "Franks", "given": "Camilla A", "initials": "CA"}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c29a5a2d88b0407ba2e3d62baffffa3e.json"}}, {"family": "Spiliopoulos", "given": "Lampros", "initials": "L"}, {"family": "Adami", "given": "Hans-Olov", "initials": "HO", "orcid": "0000-0001-9592-5791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba3e4202c4be46ed9a2836ba631dce1e.json"}}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J", "orcid": "0000-0003-1883-2000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e88fdca336ae41c891f0a46e2481b67f.json"}}, {"family": "Engblom", "given": "Stefan", "initials": "S", "orcid": "0000-0002-3614-1732", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2d5c78e143c44eba2f0e8b463cefc5d.json"}}, {"family": "Fall", "given": "Katja", "initials": "K", "orcid": "0000-0002-3649-2639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa0adf9b952e4e998c4a2deb07be5907.json"}}, {"family": "Grimby-Ekman", "given": "Anna", "initials": "A", "orcid": "0000-0002-9408-6065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c55950a9f1f4f868363a84975157fe4.json"}}, {"family": "Litton", "given": "Jan-Eric", "initials": "JE"}, {"family": "Martinell", "given": "Mats", "initials": "M"}, {"family": "Oudin", "given": "Anna", "initials": "A", "orcid": "0000-0002-9876-0627", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46d26c6a20434968a730560fb7b160a2.json"}}, {"family": "Sj\u00f6str\u00f6m", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Timpka", "given": "Toomas", "initials": "T", "orcid": "0000-0001-6049-5402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebcb4fac20f845a4bd9eaa4bf1660ebb.json"}}, {"family": "Sudre", "given": "Carole H", "initials": "CH", "orcid": "0000-0001-5753-428X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c26472813fed4007a8757af771de1802.json"}}, {"family": "Graham", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-4170-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f5f4e19812a46ed9e873732ec25e28d.json"}}, {"family": "du Cadet", "given": "Julien Lavigne", "initials": "JL"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "Davies", "given": "Richard", "initials": "R", "orcid": "0000-0003-2050-3994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b82cc92615f462d9af0153a6fb94fde.json"}}, {"family": "Ganesh", "given": "Sajaysurya", "initials": "S"}, {"family": "May", "given": "Anna", "initials": "A"}, {"family": "Ourselin", "given": "S\u00e9bastien", "initials": "S", "orcid": "0000-0002-5694-5340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74c7b9b1633144879042d198c7205656.json"}}, {"family": "Pujol", "given": "Joan Capdevila", "initials": "JC"}, {"family": "Selvachandran", "given": "Somesh", "initials": "S"}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}, {"family": "Gomez", "given": "Maria F", "initials": "MF", "orcid": "0000-0001-6210-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e09e37219c4f42c8a7b3a982da523859.json"}}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74cf1f7094744ee289fa5df041e7cb5b.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f34c0d3602439abe6096293c7c732d.json"}}], "type": "journal article", "published": "2022-04-21", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "13", "issue": "1", "pages": "2110"}, "abstract": "The app-based COVID Symptom Study was launched in Sweden in April 2020 to contribute to real-time COVID-19 surveillance. We enrolled 143,531 study participants (\u226518 years) who contributed 10.6 million daily symptom reports between April 29, 2020 and February 10, 2021. Here, we include data from 19,161 self-reported PCR tests to create a symptom-based model to estimate the individual probability of symptomatic COVID-19, with an AUC of 0.78 (95% CI 0.74-0.83) in an external dataset. These individual probabilities are employed to estimate daily regional COVID-19 prevalence, which are in turn used together with current hospital data to predict next week COVID-19 hospital admissions. We show that this hospital prediction model demonstrates a lower median absolute percentage error (MdAPE: 25.9%) across the five most populated regions in Sweden during the first pandemic wave than a model based on case notifications (MdAPE: 30.3%). During the second wave, the error rates are similar. When we apply the same model to an English dataset, not including local COVID-19 test data, we observe MdAPEs of 22.3% and 19.0% during the first and second pandemic waves, respectively, highlighting the transferability of the prediction model.", "doi": "10.1038/s41467-022-29608-7", "pmid": "35449172", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9023535"}, {"db": "pii", "key": "10.1038/s41467-022-29608-7"}], "notes": [], "created": "2021-06-23T07:15:51.852Z", "modified": "2023-01-13T13:31:54.600Z"}, {"entity": "publication", "iuid": "a6fbf67199f54aef93b69717f097602d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6fbf67199f54aef93b69717f097602d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6fbf67199f54aef93b69717f097602d"}}, "title": "Uncontrolled asthma predicts severe COVID-19: a report from the Swedish National Airway Register.", "authors": [{"family": "Karlsson Sundbaum", "given": "Johanna", "initials": "J", "orcid": "0000-0001-5313-7981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8b5dfbfb761446aa474013fcccdd085.json"}}, {"family": "Konradsen", "given": "Jon R", "initials": "JR"}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW"}, {"family": "Axelsson Fisk", "given": "Sten", "initials": "S"}, {"family": "Pedroletti", "given": "Christophe", "initials": "C"}, {"family": "Sj\u00f6\u00f6", "given": "Yvonne", "initials": "Y"}, {"family": "Syk", "given": "J\u00f6rgen", "initials": "J"}, {"family": "Sterner", "given": "Therese", "initials": "T"}, {"family": "Lindberg", "given": "Anne", "initials": "A"}, {"family": "Tuns\u00e4ter", "given": "Alf", "initials": "A"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ekberg-Jansson", "given": "Ann", "initials": "A"}, {"family": "Stridsman", "given": "Caroline", "initials": "C", "orcid": "0000-0001-6622-3838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e2fc66fb68748eba5a7f8eb93c5ff3f.json"}}], "type": "journal article", "published": "2022-04-19", "journal": {"title": "Ther Adv Respir Dis", "issn": "1753-4666", "issn-l": null, "volume": "16", "issue": null, "pages": "17534666221091183"}, "abstract": "Severe asthma increases the risk of severe COVID-19 outcomes such as hospitalization and death. However, more studies are needed to understand the association between asthma and severe COVID-19.\r\n\r\nA cohort of 150,430 adult asthma patients were identified in the Swedish National Airway Register (SNAR) from 2013 to December 2020. Data on body mass index, smoking habits, lung function, and asthma control test (ACT) were obtained from SNAR, and uncontrolled asthma was defined as ACT \u2a7d19. Patients with severe COVID-19 were identified following hospitalization or in death certificates based on ICD-10 codes U07.1 and U07.2. The Swedish Prescribed Drug register was used to identify comorbidities and data from Statistics Sweden for educational level. Multivariate logistic regression analyses were used to estimate associations with severe COVID-19.\r\n\r\nSevere COVID-19 was identified in 1067 patients (0.7%). Older age (OR = 1.04, 95% CI = 1.03-1.04), male sex (1.42, 1.25-1.61), overweight (1.56, 1.27-1.91), obesity (2.12, 1.73-2.60), high-dose inhaled corticosteroids in combination with long-acting \u03b2-agonists (1.40, 1.22-1.60), dispensed oral corticosteroids \u2a7e2 (1.48, 1.25-1.75), uncontrolled asthma (1.64, 1.35-2.00), cardiovascular disease (1.20, 1.03-1.40), depression (1.47, 1.28-1.68), and diabetes (1.52, 1.29-1.78) were associated with severe COVID-19, while current smoking was inversely associated (0.63, 0.47-0.85). When comparing patients who died from COVID-19 with those discharged alive from hospital until 31 December 2020, older age, male sex, and current smoking were associated with COVID-19 death.\r\n\r\nPatients with uncontrolled asthma and high disease burden, including increased asthma medication intensity, should be identified as risk patients for severe COVID-19. Furthermore, current smoking is strongly associated with COVID-19 death in asthma.", "doi": "10.1177/17534666221091183", "pmid": "35430944", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pmc", "key": "PMC9019327"}], "notes": [], "created": "2023-01-13T09:54:31.722Z", "modified": "2023-01-13T09:56:02.884Z"}, {"entity": "publication", "iuid": "17d4b6ebe48f4891bf1e5a56692d5e69", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/17d4b6ebe48f4891bf1e5a56692d5e69.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/17d4b6ebe48f4891bf1e5a56692d5e69"}}, "title": "The Evolution of Blood Cell Phenotypes, Intracellular and Plasma Cytokines and Morphological Changes in Critically Ill COVID-19 Patients.", "authors": [{"family": "Bergh\u00e4ll", "given": "Elisabeth", "initials": "E", "orcid": "0000-0002-3287-6504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6aacfcdf39b46daaa541c3123927ab6.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Hahn-Str\u00f6mberg", "given": "Victoria", "initials": "V"}], "type": "journal article", "published": "2022-04-19", "journal": {"title": "Biomedicines", "issn": "2227-9059", "issn-l": null, "volume": "10", "issue": "5", "pages": null}, "abstract": "Severe coronavirus disease 2019 (COVID-19) causes a strong inflammatory response. To obtain an overview of inflammatory mediators and effector cells, we studied 25 intensive-care-unit patients during the timeframe after off-label chloroquine treatment and before an introduction of immunomodulatory drugs.\r\n\r\nBlood samples were weekly examined with flow cytometry (FCM) for surface and intracytoplasmic markers, cytokine assays were analyzed for circulating interleukins (ILs), and blood smears were evaluated for morphological changes. Samples from healthy volunteers were used for comparison. Organ function data and 30-day mortality were obtained from medical records.\r\n\r\nCompared to that of the healthy control group, the expression levels of leukocyte surface markers, i.e., the cluster of differentiation (CD) markers CD2, CD4, CD8, CD158d, CD25, CD127, and CD19, were lower (p &lt; 0.001), while those of leukocytes expressing CD33 were increased (p &lt; 0.05). An aberrant expression of CD158d on granulocytes was found on parts of the granulocyte population. The expression levels of intracellular tumor necrosis factor alpha (TNF\u03b1) and IL-1 receptor type 2 in leukocytes were higher (p &lt; 0.001) as well as plasma levels of TNF\u03b1, IL-2, IL-6, IL-8, IL-10 (p &lt; 0.001), interferon gamma (IFN\u03b3) (p &lt; 0.01), and granulocyte-macrophage colony-stimulating factor (GM-CSF) (p &lt; 0.05). The expression levels of CD33+ leukocytes and circulating IL-6 were higher (p &lt; 0.05) among patients with arterial oxygen partial pressure-to-fractional inspired oxygen (PaO2/FiO2) ratios below 13.3 kPa compared to in the remaining patients. The expression levels of TNF\u03b1, IL-2, IL-4, IL-6, IL-8, and IL-10 were higher in patients treated with continuous renal replacement therapy (CRRT) (p &lt; 0.05), and the levels of the maximum plasma creatinine and TNF\u03b1 Spearman's rank-order correlation coefficient (rho = 0.51, p &lt; 0.05) and IL-8 (rho = 0.44, p &lt; 0.05) correlated. Blood smears revealed neutrophil dysplasia with pseudo-Pelger forms being most common.\r\n\r\nThese findings suggest that patients with severe COVID-19, in addition to augmented ILs, lymphopenia, and increased granulocytes, also had effects on the bone marrow.", "doi": "10.3390/biomedicines10050934", "pmid": "35625671", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "biomedicines10050934"}], "notes": [], "created": "2022-06-21T17:43:10.166Z", "modified": "2022-08-19T12:34:49.174Z"}, {"entity": "publication", "iuid": "811f1f490b264020b8b6e2c851d2ef83", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/811f1f490b264020b8b6e2c851d2ef83.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/811f1f490b264020b8b6e2c851d2ef83"}}, "title": "Dissecting the Molecular Mechanisms Surrounding Post-COVID-19 Syndrome and Neurological Features.", "authors": [{"family": "Mohamed", "given": "Mohamed S", "initials": "MS"}, {"family": "Johansson", "given": "Anton", "initials": "A"}, {"family": "Jonsson", "given": "J\u00f6rgen", "initials": "J"}, {"family": "Schi\u00f6th", "given": "Helgi B", "initials": "HB"}], "type": "journal article", "published": "2022-04-12", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "23", "issue": "8", "issn-l": null}, "abstract": "Many of the survivors of the novel coronavirus disease (COVID-19) are suffering from persistent symptoms, causing significant morbidity and decreasing their quality of life, termed \"post-COVID-19 syndrome\" or \"long COVID\". Understanding the mechanisms surrounding PCS is vital to developing the diagnosis, biomarkers, and possible treatments. Here, we describe the prevalence and manifestations of PCS, and similarities with previous SARS epidemics. Furthermore, we look at the molecular mechanisms behind the neurological features of PCS, where we highlight important neural mechanisms that may potentially be involved and pharmacologically targeted, such as glutamate reuptake in astrocytes, the role of NMDA receptors and transporters (EAAT2), ROS signaling, astrogliosis triggered by NF-\u03baB signaling, KNDy neurons, and hypothalamic networks involving Kiss1 (a ligand for the G-protein-coupled receptor 54 (GPR54)), among others. We highlight the possible role of reactive gliosis following SARS-CoV-2 CNS injury, as well as the potential role of the hypothalamus network in PCS manifestations.", "doi": "10.3390/ijms23084275", "pmid": "35457093", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC9028501"}, {"db": "pii", "key": "ijms23084275"}], "notes": [], "created": "2023-01-13T13:33:37.680Z", "modified": "2023-01-13T13:33:37.694Z"}, {"entity": "publication", "iuid": "55a6ebbc875e40729467c6ea2c76a8a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/55a6ebbc875e40729467c6ea2c76a8a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/55a6ebbc875e40729467c6ea2c76a8a6"}}, "title": "Specific T-cell responses for guiding treatment with convalescent plasma in severe COVID-19 and humoral immunodeficiency: a case report.", "authors": [{"family": "Nystr\u00f6m", "given": "Katarina", "initials": "K"}, {"family": "Hjorth", "given": "Maria", "initials": "M"}, {"family": "Fust", "given": "Ramona", "initials": "R"}, {"family": "Nilsdotter-Augustinsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Larsson", "given": "Marie", "initials": "M"}, {"family": "Niward", "given": "Katarina", "initials": "K"}, {"family": "Nystr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0002-0145-4966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56bc7bc8ab444c81afd336394ae7607d.json"}}], "type": "case reports", "published": "2022-04-11", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "volume": "22", "issue": "1", "pages": "362", "issn-l": null}, "abstract": "The immune response to SARS-CoV-2 virus, the cause of COVID-19, is complex. Antibody mediated responses are important for viral clearance but may also drive hyperinflammation in severe COVID-19. We present a case of an individual with a genetic inability to produce antibodies and severe COVID-19, receiving no other specific anti-viral treatment than convalescent COVID-19 plasma, illustrating that hyperinflammation can occur in the absence of a humoral anti-viral response. In addition, the case illustrates that the assessment of SARS-CoV-2 T cell responses can facilitate clinical decision making in patients with COVID-19 and weak or absent humoral immune responses.\n\nA male with X-linked agammaglobulinemia on regular immunoglobulin replacement therapy, hospitalized for 35 days due to severe COVID-19. Systemic inflammatory parameters were highly elevated. After treatment with convalescent COVID-19 plasma he became afebrile and the fatigue diminished. He was discharged on day 42 and nasopharyngeal SARS-CoV-2 PCR eventually was negative on day 49. Evidence of SARS-CoV-2 specific T cells prior to administration of plasma therapy suggested that antibodies were crucial for viral clearance. Regular assessment showed robust and persistent SARS-CoV-2 specific T-cell responses after recovery suggested that prophylactic administration of convalescent COVID-19 plasma was unnecessary.\n\nAssessment of SARS-CoV-2T-cell responses can facilitate the clinical management of COVID-19 patients with humoral immunodeficiencies.", "doi": "10.1186/s12879-022-07323-4", "pmid": "35410137", "labels": {"Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12879-022-07323-4"}, {"db": "pmc", "key": "PMC8996199"}], "notes": [], "created": "2022-10-13T13:01:08.111Z", "modified": "2022-10-13T13:01:08.145Z"}, {"entity": "publication", "iuid": "ed9f0221711e4437bea0df3752e4e0fe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed9f0221711e4437bea0df3752e4e0fe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed9f0221711e4437bea0df3752e4e0fe"}}, "title": "Impact of covid-19 on long-term oxygen therapy 2020: A nationwide study in Sweden.", "authors": [{"family": "Sundh", "given": "Josefin", "initials": "J", "orcid": "0000-0003-1926-8464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0994c494df3b4955bedb00606add70d6.json"}}, {"family": "Palm", "given": "Andreas", "initials": "A"}, {"family": "Wahlberg", "given": "Josefin", "initials": "J"}, {"family": "Runold", "given": "Michael", "initials": "M"}, {"family": "Ekstr\u00f6m", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2022-04-08", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "4", "pages": "e0266367", "issn-l": "1932-6203"}, "abstract": "Covid-19 can cause chronic hypoxic respiratory failure, but the impact on the need for long-term oxygen therapy (LTOT) is unknown. The aim was to investigate change in incidence and characteristics of patients starting LTOT in Sweden 2020 after the outbreak of the pandemic.\n\nPopulation-based observational study using data from the National Registry for Respiratory Failure (Swedevox) and from a survey to all centres prescribing LTOT in Sweden. Swedevox data provided information on incidence of LTOT and characteristics of patients starting LTOT during 2015-2020.\n\nBetween March-Dec 2020, 131 patients started LTOT due to covid-19, corresponding to 20.5% of incident LTOT in Sweden. Compared with 2015-19, the total number of patients starting LTOT did not increase. No significant differences in patient characteristics or underlying causes of hypoxemia were found between patients starting LTOT during 2020 compared 2015-2019. The majority of the LTOT centres estimated that, since the start of the pandemic, the incidence of LTOT was unchanged and the time devoted for LTOT work was the same or slightly less.\n\nCovid-19 caused one fifth of all LTOT starts during the pandemic in 2020. The LTOT incidence overall did not increase possibly due to reduction in other infections.", "doi": "10.1371/journal.pone.0266367", "pmid": "35395039", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8992997"}, {"db": "pii", "key": "PONE-D-21-37749"}], "notes": [], "created": "2023-01-13T13:41:15.466Z", "modified": "2023-01-13T13:41:15.492Z"}, {"entity": "publication", "iuid": "cc323c7ea5b948ddb0f5c9673daaaa59", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc323c7ea5b948ddb0f5c9673daaaa59.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc323c7ea5b948ddb0f5c9673daaaa59"}}, "title": "An olfactory self-test effectively screens for COVID-19.", "authors": [{"family": "Snitz", "given": "Kobi", "initials": "K"}, {"family": "Honigstein", "given": "Danielle", "initials": "D"}, {"family": "Weissgross", "given": "Reut", "initials": "R", "orcid": "0000-0002-6554-9462", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03bcaa7f65b342719a8e846b28c2b282.json"}}, {"family": "Ravia", "given": "Aharon", "initials": "A", "orcid": "0000-0003-2183-9254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3599c1d815e04e338fe4440fdc95be77.json"}}, {"family": "Mishor", "given": "Eva", "initials": "E", "orcid": "0000-0003-4006-3789", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2ede0162e8d4daf81350bacab4d7f9d.json"}}, {"family": "Perl", "given": "Ofer", "initials": "O"}, {"family": "Karagach", "given": "Shiri", "initials": "S"}, {"family": "Medhanie", "given": "Abebe", "initials": "A"}, {"family": "Harel", "given": "Nir", "initials": "N"}, {"family": "Shushan", "given": "Sagit", "initials": "S"}, {"family": "Roth", "given": "Yehudah", "initials": "Y"}, {"family": "Iravani", "given": "Behzad", "initials": "B", "orcid": "0000-0001-9905-1067", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5c799aeccef49a59531ad96984f466b.json"}}, {"family": "Arshamian", "given": "Artin", "initials": "A"}, {"family": "Ernst", "given": "Gernot", "initials": "G", "orcid": "0000-0001-5224-0338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/afb20633af994b808d8e6818812afa59.json"}}, {"family": "Okamoto", "given": "Masako", "initials": "M"}, {"family": "Poo", "given": "Cindy", "initials": "C"}, {"family": "Bonacchi", "given": "Niccol\u00f2", "initials": "N", "orcid": "0000-0001-5228-6918", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b985fa7a1f24d44bd254daba559c128.json"}}, {"family": "Mainen", "given": "Zachary", "initials": "Z", "orcid": "0000-0001-7913-9109", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a189fcf3c6d41f98339f08ebdf8244a.json"}}, {"family": "Monteleone", "given": "Erminio", "initials": "E"}, {"family": "Dinnella", "given": "Caterina", "initials": "C", "orcid": "0000-0002-5765-6057", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/315a95a9248c43dfb7ed2231824b6ced.json"}}, {"family": "Spinelli", "given": "Sara", "initials": "S"}, {"family": "Mari\u00f1o-S\u00e1nchez", "given": "Franklin", "initials": "F"}, {"family": "Ferdenzi", "given": "Camille", "initials": "C"}, {"family": "Smeets", "given": "Monique", "initials": "M"}, {"family": "Touhara", "given": "Kazushige", "initials": "K"}, {"family": "Bensafi", "given": "Moustafa", "initials": "M", "orcid": "0000-0002-2991-3036", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11b9f8b4dfbd4345ad03a0a694d5efcd.json"}}, {"family": "Hummel", "given": "Thomas", "initials": "T"}, {"family": "Lundstr\u00f6m", "given": "Johan N", "initials": "JN", "orcid": "0000-0002-3529-8981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a92f50aea024a1fbf0cfda979efef11.json"}}, {"family": "Sobel", "given": "Noam", "initials": "N", "orcid": "0000-0002-3232-9391", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34beac29a3ed4d169aa33d270f09d186.json"}}], "type": "journal article", "published": "2022-04-05", "journal": {"title": "Commun Med (Lond)", "issn": "2730-664X", "volume": "2", "pages": "34", "issn-l": null}, "abstract": "Key to curtailing the COVID-19 pandemic are wide-scale screening strategies. An ideal screen is one that would not rely on transporting, distributing, and collecting physical specimens. Given the olfactory impairment associated with COVID-19, we developed a perceptual measure of olfaction that relies on smelling household odorants and rating them online.\n\nEach participant was instructed to select 5 household items, and rate their perceived odor pleasantness and intensity using an online visual analogue scale. We used this data to assign an olfactory perceptual fingerprint, a value that reflects the perceived difference between odorants. We tested the performance of this real-time tool in a total of 13,484 participants (462 COVID-19 positive) from 134 countries who provided 178,820 perceptual ratings of 60 different household odorants.\n\nWe observe that olfactory ratings are indicative of COVID-19 status in a country, significantly correlating with national infection rates over time. More importantly, we observe indicative power at the individual level (79% sensitivity and 87% specificity). Critically, this olfactory screen remains effective in participants with COVID-19 but without symptoms, and in participants with symptoms but without COVID-19.\n\nThe current odorant-based olfactory screen adds a component to online symptom-checkers, to potentially provide an added first line of defense that can help fight disease progression at the population level. The data derived from this tool may allow better understanding of the link between COVID-19 and olfaction.", "doi": "10.1038/s43856-022-00095-7", "pmid": "35603293", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "95"}, {"db": "pmc", "key": "PMC9053292"}], "notes": [], "created": "2022-06-21T17:55:17.396Z", "modified": "2022-11-21T15:30:33.313Z"}, {"entity": "publication", "iuid": "049abad9f8c946609902e95615a648a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/049abad9f8c946609902e95615a648a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/049abad9f8c946609902e95615a648a6"}}, "title": "Impact of post-COVID conditions on mental health: a cross-sectional study in Japan and Sweden.", "authors": [{"family": "Matsumoto", "given": "Kazuki", "initials": "K"}, {"family": "Hamatani", "given": "Sayo", "initials": "S", "orcid": "0000-0001-7847-6381", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ed7722373ad4aed8a58e4ee130a925f.json"}}, {"family": "Shimizu", "given": "Eiji", "initials": "E"}, {"family": "K\u00e4ll", "given": "Anton", "initials": "A"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}], "type": "journal article", "published": "2022-04-04", "journal": {"title": "BMC Psychiatry", "issn": "1471-244X", "volume": "22", "issue": "1", "pages": "237", "issn-l": null}, "abstract": "Due to the coronavirus disease 2019 (COVID-19) pandemic, people have undermined their mental health. It has been reported that post-COVID conditions at a certain rate. However, information on the mental health of people with post-COVID conditions is limited. Thus, this study investigated the relationship between post-COVID conditions and mental health.\n\nDesign of the present study was an International and collaborative cross-sectional study in Japan and Sweden from March 18 to June 15, 2021. The analyzed data included 763 adults who participated in online surveys in Japan and Sweden and submitted complete data. In addition to demographic data including terms related to COVID-19, psychiatric symptoms such as depression, anxiety, and post-traumatic stress were measured by using the fear of COVID-19 scale (FCV-19S), Patient Health Questionnaire-9 (PHQ-9), General Anxiety Disorder-7 item (GAD-7), and Impact of Event Scale-Revised (IES-R).\n\nOf the 135 COVID-19 survivors among the 763 total participants, 37.0% (n = 50/135) had COVID-19-related sequelae. First, the results of the Bonferroni-corrected Mann Whitney U test showed that the group infected SARS-CoV-2 with post-COVID conditions scored significantly higher than those without one and the non-infected group on all clinical symptom scales (P \u2264 .05). Next, there was a significant difference that incidence rates of clinical-significant psychiatric symptoms among each group from the results of the Chi-squared test (P \u2264 .001). Finally, the results of the multivariate logistic model revealed that the risk of having more severe clinical symptoms were 2.44-3.48 times higher among participants with post-COVID conditions.\n\nThe results showed that approximately half had some physical symptoms after COVID-19 and that post-COVID conditions may lead to the onset of mental disorders.\n\nThe ethics committee of Chiba University approved this cross-sectional study (approval number: 4129). However, as no medical intervention was conducted, a clinical trial registration was not necessary.", "doi": "10.1186/s12888-022-03874-7", "pmid": "35379224", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8977559"}, {"db": "pii", "key": "10.1186/s12888-022-03874-7"}], "notes": [], "created": "2023-01-13T13:40:33.923Z", "modified": "2023-01-13T13:40:33.970Z"}, {"entity": "publication", "iuid": "1dd2f6a205d9420394113cfef0c78c22", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1dd2f6a205d9420394113cfef0c78c22.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1dd2f6a205d9420394113cfef0c78c22"}}, "title": "COVID-19 IDD: Findings from a global survey exploring family members' and paid staff's perceptions of the impact of COVID-19 on individuals with intellectual and developmental disabilities (IDD) and their caregivers.", "authors": [{"family": "Linehan", "given": "Christine", "initials": "C", "orcid": "0000-0002-9083-3457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b2eec9989c3470fb49471050007ea84.json"}}, {"family": "Birkbeck", "given": "Gail", "initials": "G"}, {"family": "Araten-Bergman", "given": "Tal", "initials": "T", "orcid": "0000-0003-4915-2729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aaffeee537eb4a27b785d4e4db4134c6.json"}}, {"family": "Baumbusch", "given": "Jennifer", "initials": "J"}, {"family": "Beadle-Brown", "given": "Julie", "initials": "J"}, {"family": "Bigby", "given": "Christine", "initials": "C", "orcid": "0000-0001-7001-8976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb03eecfdf5748ccadd49117bea5b00b.json"}}, {"family": "Bradley", "given": "Valerie", "initials": "V"}, {"family": "Brown", "given": "Michael", "initials": "M", "orcid": "0000-0003-3230-401X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34355c671e7b491cbd5b76429680aad3.json"}}, {"family": "Bredewold", "given": "Femmianne", "initials": "F", "orcid": "0000-0002-6231-8263", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7dca30eb8e3f487fb8f7f1bf67d44ed5.json"}}, {"family": "Chirwa", "given": "Masauso", "initials": "M", "orcid": "0000-0002-6293-5034", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f99b5be63ea94917a122bba4751e0168.json"}}, {"family": "Cui", "given": "Jialiang", "initials": "J", "orcid": "0000-0001-8708-1947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/393d73a952544ea28655eb9073fe42b1.json"}}, {"family": "Godoy Gimenez", "given": "Marta", "initials": "M"}, {"family": "Gomeiro", "given": "Tiziano", "initials": "T", "orcid": "0000-0002-2931-9571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74a9af063b354d07bf09cd1f73dac2de.json"}}, {"family": "Kanova", "given": "\u0160\u00e1rka", "initials": "\u0160", "orcid": "0000-0003-0846-5737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19dc6d08bfa648feba2d4d0fa83b6dca.json"}}, {"family": "Kroll", "given": "Thilo", "initials": "T", "orcid": "0000-0003-2082-5117", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb39d4a6cc8f439581040333ce92d6bb.json"}}, {"family": "Li", "given": "Henan", "initials": "H"}, {"family": "MacLachlan", "given": "Mac", "initials": "M"}, {"family": "Narayan", "given": "Jayanthi", "initials": "J", "orcid": "0000-0001-5125-0227", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58b00b867ac3442d8d9d316d9d2dc036.json"}}, {"family": "Nearchou", "given": "Finiki", "initials": "F", "orcid": "0000-0002-2018-9096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db4b9458035a4304a7e588be8533b39c.json"}}, {"family": "Nolan", "given": "Adam", "initials": "A"}, {"family": "O'Donovan", "given": "Mary-Ann", "initials": "MA", "orcid": "0000-0002-3378-5305", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af60d1c4e1464ffaa3c0499892d9fd0e.json"}}, {"family": "Santos", "given": "Flavia H", "initials": "FH", "orcid": "0000-0003-2592-9038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7e5d5f9645d48fabc19480b9af1d79e.json"}}, {"family": "\u0160i\u0161ka", "given": "Jan", "initials": "J", "orcid": "0000-0003-2379-2285", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5471f9d32d384e13a0fcc75e62df4766.json"}}, {"family": "Stainton", "given": "Tim", "initials": "T", "orcid": "0000-0002-5146-2497", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d297befd524e494f8f100394ab2cd84a.json"}}, {"family": "Tideman", "given": "Magnus", "initials": "M", "orcid": "0000-0002-7519-6488", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96ec2f02bc4b40ddadf2969252205539.json"}}, {"family": "Tossebro", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2022-04-04", "journal": {"title": "HRB Open Res", "issn": "2515-4826", "volume": "5", "pages": "27", "issn-l": null}, "abstract": "Background: A growing body of evidence attests to the disproportionate impact of COVID-19 on persons with intellectual and developmental disabilities (IDD) during the pandemic. This study asked caregivers about their perceptions of how COVID-19 impacted them and the people they support. Method: An online survey was conducted in 12 countries during August-September 2020 and sought information on demographics, support practices, information and training, experiences of COVID-19, social distancing, and wellbeing, as measured by the DASS12. This study reports on 3,754 family members, direct support professionals, and managers who participated in the survey. Results: Caregivers observed increases in depression/anxiety, stereotyped behaviours, aggression towards others and weight gain in the person(s) they supported. They also reported difficulties supporting the person(s) to access healthcare. Families reported reducing or ceasing employment and absorbed additional costs when supporting their family member. Direct support professionals experienced changes in staff shifts, staff absences, increased workload and hiring of casual staff. Caregivers' wellbeing revealed high levels of stress, depression, and less so anxiety. The strongest predictor of wellbeing among families was observation of changes in mood in the person(s) they supported, while for direct support professionals, the strongest predictors of wellbeing were reorganisation of staff shifts and increases in new direct support staff. Discussion: Findings support the contention of this population experiencing a disproportionate burden during the COVID-19 pandemic, reflecting historical inequities in access to healthcare and other human rights violations which are now protected under the United Nations Convention on the Rights of Persons with Disabilities.", "doi": "10.12688/hrbopenres.13497.1", "pmid": "35615436", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9111363"}], "notes": [], "created": "2022-06-21T17:49:34.094Z", "modified": "2022-06-21T17:49:34.715Z"}, {"entity": "publication", "iuid": "bbccc3d17c0f49868fc33a111d36c981", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bbccc3d17c0f49868fc33a111d36c981.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bbccc3d17c0f49868fc33a111d36c981"}}, "title": "Correlates of protection, viral load trajectories and symptoms in BA.1, BA.1.1 and BA.2 breakthrough infections in triple vaccinated healthcare workers", "authors": [{"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Greilert Norin", "given": "Nina", "initials": "N"}, {"family": "Bladh", "given": "Oscar", "initials": "O"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Ng", "given": "Henry", "initials": "H"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "Smed S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-4172-975X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc8af93ec4fa47959515a7b39b10a795.json"}}], "type": "posted-content", "published": "2022-04-03", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.04.02.22273333", "pmid": null, "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2022-10-13T15:17:24.431Z", "modified": "2023-06-19T14:27:45.410Z"}, {"entity": "publication", "iuid": "52c856fe22854e7c81a7c9caff161ffa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/52c856fe22854e7c81a7c9caff161ffa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/52c856fe22854e7c81a7c9caff161ffa"}}, "title": "Angiotensin-converting enzyme 2 and Transmembrane protease serine 2 in female and male patients with end-stage kidney disease.", "authors": [{"family": "Arefin", "given": "Samsul", "initials": "S", "orcid": "0000-0002-8050-9100", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0be84768aaf64d4484f0ba0ea99861d3.json"}}, {"family": "Hernandez", "given": "Leah", "initials": "L"}, {"family": "Ward", "given": "Liam J", "initials": "LJ"}, {"family": "Schwarz", "given": "Angelina", "initials": "A"}, {"family": "Barany", "given": "Peter", "initials": "P"}, {"family": "Stenvinkel", "given": "Peter", "initials": "P"}, {"family": "Kublickiene", "given": "Karolina", "initials": "K"}, {"family": "GOING-FWD Collaborators", "given": "", "initials": ""}], "type": "journal article", "published": "2022-04-02", "journal": {"title": "Eur J Clin Invest", "issn": "1365-2362", "pages": "e13786", "issn-l": null}, "abstract": "Individuals with chronic kidney disease are affected by acute respiratory syndrome coronavirus 2 (SARS-CoV-2) due to multiple comorbidities and altered immune system. The first step of the infection process is the binding of SARS-CoV-2 with angiotensin-converting enzyme 2 (ACE2) receptor, followed by its priming by transmembrane protease serine 2 (TMPRSS2). We hypothesized that circulating soluble ACE2 levels, as well as the expressions of ACE2 and TMPRSS2 in the microvasculature, are increased in patients with end-stage kidney disease (ESKD).\n\nA total of 210 participants were enrolled, representing 80 ESKD patients and 73 non-CKD controls for soluble ACE2, and 31 ESKD and 26 non-CKD controls for vasculature and fat tissue bioassays. We have assessed ACE2 expression in blood using ELISA and in tissue using immunofluorescence.\n\nSoluble ACE2 levels were higher in ESKD patients compared to controls however, there is no sex difference observed. In ESKD and controls, soluble ACE2 positively correlated with IL-6 and hsCRP respectively. Similarly, ACE2 tissue expression in the vasculature was higher in ESKD patients, moreover, this higher ACE2 expression was observed only in male ESKD patients. In addition, TMPRSS2 expression was observed in vessels from males and females but showed no sex difference. The expression of ACE2 receptor was higher in ESKD patients on ACE-inhibitor/angiotensin blocker treatment.\n\nESKD is associated with increased ACE2 levels in the circulation and pronounced in male vasculature, however further studies are warranted to assess possible sex differences on specific treatment regime(s) for different comorbidities present in ESKD.", "doi": "10.1111/eci.13786", "pmid": "35366343", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-04-04T06:22:59.917Z", "modified": "2022-04-04T06:23:32.705Z"}, {"entity": "publication", "iuid": "ce32d7ce04f74c4e8ee3ca08a4e892e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ce32d7ce04f74c4e8ee3ca08a4e892e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ce32d7ce04f74c4e8ee3ca08a4e892e7"}}, "title": "ABO and RhD blood group are not associated with mortality and morbidity in critically ill patients; a multicentre observational study of 29 512 patients.", "authors": [{"family": "Kander", "given": "Thomas", "initials": "T"}, {"family": "Bjurstr\u00f6m", "given": "Martin F", "initials": "MF"}, {"family": "Frigyesi", "given": "Attila", "initials": "A"}, {"family": "J\u00f6ud", "given": "Magnus", "initials": "M"}, {"family": "Nilsson", "given": "Caroline U", "initials": "CU"}], "type": "journal article", "published": "2022-04-02", "journal": {"title": "BMC Anesthesiol", "issn": "1471-2253", "volume": "22", "issue": "1", "pages": "91", "issn-l": null}, "abstract": "The ABO and RhD blood group represent antigens on the surface of erythrocytes. The ABO blood group antigens are also present on multiple other cells. Interestingly, previous studies have demonstrated associations between the blood group and many types of disease. The present study aimed to identifying associations between the ABO blood group, the RhD blood group, and morbidity and mortality in a mixed cohort and in six pre-defined subgroups of critically ill patients.\n\nAdult patients admitted to any of the five intensive care units (ICUs) in the Scania Region, Sweden, between February 2007 and April 2021 were eligible for inclusion. The outcomes were mortality analysed at 28- and 90-days as well as at the end of observation and morbidity measured using days alive and free of (DAF) invasive ventilation (DAF ventilation) and DAF circulatory support, including vasopressors or inotropes (DAF circulation), maximum Sequential Organ Failure Assessment score (SOFAmax) the first 28 days after admission and length of stay. All outcomes were analysed in separate multivariable regression models adjusted for age and sex. In addition, in a sensitivity analysis, five subgroups of patients with the main diagnoses sepsis, septic shock, acute respiratory distress syndrome, cardiac arrest and trauma were analysed using the same separate multivariable regression models.\n\nIn total, 29,512 unique patients were included in the analyses. There were no significant differences for any of the outcomes between non-O blood groups and blood group O, or between RhD blood groups. In the sensitivity analysis of subgroups, there were no differences in mortality between non-O blood groups and blood group O or between the RhD blood groups. AB was the most common blood group in the COVID-19 cohort.\n\nThe ABO and RhD blood group do not influence mortality or morbidity in a general critically ill patient population.", "doi": "10.1186/s12871-022-01626-4", "pmid": "35366803", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12871-022-01626-4"}], "notes": [], "created": "2022-04-04T06:22:38.196Z", "modified": "2022-04-04T06:22:38.231Z"}, {"entity": "publication", "iuid": "dbd6140519994f4bad11d82be6f43d99", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dbd6140519994f4bad11d82be6f43d99.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dbd6140519994f4bad11d82be6f43d99"}}, "title": "VCA in the Era of the COVID-19 Pandemic.", "authors": [{"family": "Petruzzo", "given": "Palmina", "initials": "P"}, {"family": "Kanitakis", "given": "Jean", "initials": "J"}, {"family": "Sardu", "given": "Claudia", "initials": "C"}, {"family": "Bassiri Gharb", "given": "Bahar", "initials": "B"}, {"family": "Morelon", "given": "Emmanuel", "initials": "E"}, {"family": "Amer", "given": "Hatem", "initials": "H"}, {"family": "Barret", "given": "Juan", "initials": "J"}, {"family": "Burt", "given": "James", "initials": "J"}, {"family": "Brandacher", "given": "Gerald", "initials": "G"}, {"family": "Gomez", "given": "Tomas", "initials": "T"}, {"family": "Kay", "given": "Simon", "initials": "S"}, {"family": "Kaminska", "given": "Dorotha", "initials": "D"}, {"family": "Kaufman", "given": "Christina L", "initials": "CL"}, {"family": "Kumar", "given": "Dinesh S", "initials": "DS"}, {"family": "Iglesias", "given": "Martin", "initials": "M"}, {"family": "Iyer", "given": "Subramania", "initials": "S"}, {"family": "Landin", "given": "Luis", "initials": "L"}, {"family": "Lanzetta", "given": "Marco", "initials": "M"}, {"family": "Lassus", "given": "Patrick", "initials": "P"}, {"family": "Levin", "given": "Scott", "initials": "S"}, {"family": "Papay", "given": "Francis", "initials": "F"}, {"family": "Pomahac", "given": "Bohdan", "initials": "B"}, {"family": "Sassu", "given": "Paolo", "initials": "P"}, {"family": "Satbhai", "given": "Nilesh G", "initials": "NG"}, {"family": "Talbot", "given": "Simon", "initials": "S"}, {"family": "VCA-COVID Survey Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-04-01", "journal": {"title": "Transplantation", "issn": "1534-6080", "volume": "106", "issue": "4", "pages": "690-692", "issn-l": null}, "abstract": null, "doi": "10.1097/TP.0000000000004041", "pmid": "35333847", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "00007890-202204000-00005"}, {"db": "pmc", "key": "PMC8942593"}], "notes": [], "created": "2022-04-04T06:56:37.125Z", "modified": "2022-04-04T06:56:50.268Z"}, {"entity": "publication", "iuid": "96e41f1753ce4163b558b31d1be31822", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/96e41f1753ce4163b558b31d1be31822.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/96e41f1753ce4163b558b31d1be31822"}}, "title": "Public risk perception and behaviours towards COVID-19 during the first and second waves in Nigeria: a secondary data analysis.", "authors": [{"family": "Ochu", "given": "Chinwe Lucia", "initials": "CL", "orcid": "0000-0002-0630-7332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f390fa99a654ff899f5e9df6fbaf88e.json"}}, {"family": "Onoja", "given": "Michael", "initials": "M"}, {"family": "Olatunji", "given": "David", "initials": "D"}, {"family": "Okusanya", "given": "Babasola O", "initials": "BO"}, {"family": "Usuwa", "given": "Ifeoma Sophia", "initials": "IS", "orcid": "0000-0002-9584-784X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/faff911036d446d2aa187ecb925dbce7.json"}}, {"family": "Akeju", "given": "David O", "initials": "DO"}, {"family": "Disu", "given": "Yahya", "initials": "Y"}, {"family": "Adejo", "given": "Samuel Ojima", "initials": "SO"}, {"family": "Eziechina", "given": "Sunday", "initials": "S"}, {"family": "Nwiyi", "given": "Gloria", "initials": "G"}, {"family": "Okediran", "given": "James Olatunde", "initials": "JO"}, {"family": "Elimian", "given": "Kelly Osezele", "initials": "KO", "orcid": "0000-0003-2729-1613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/695dddf720414c3585d35b30184f0178.json"}}, {"family": "Akande", "given": "Oluwatosin Wuraola", "initials": "OW"}, {"family": "Dunkwu", "given": "Lauryn", "initials": "L"}, {"family": "Fagbemi", "given": "Babafunke", "initials": "B"}, {"family": "Aisiri", "given": "Adolor", "initials": "A"}, {"family": "Agogo", "given": "Emmanuel A", "initials": "EA"}, {"family": "Ebenso", "given": "Bassey", "initials": "B", "orcid": "0000-0003-4147-0968", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40b960008ed04f54adb2d62d088232ee.json"}}, {"family": "Oke", "given": "David Adewale", "initials": "DA"}, {"family": "Igumbor", "given": "Ehimario", "initials": "E"}, {"family": "Ihekweazu", "given": "Chikwe", "initials": "C"}], "type": "journal article", "published": "2022-04-01", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "4", "pages": "e058747", "issn-l": "2044-6055"}, "abstract": "To describe changes in public risk perception and risky behaviours during the first wave (W1) and second wave (W2) of COVID-19 in Nigeria, associated factors and observed trend of the outbreak.\n\nA secondary data analysis of cross-sectional telephone-based surveys conducted during the W1 and W2 of COVID-19 in Nigeria.\n\nNigeria.\n\nData from participants randomly selected from all states in Nigeria.\n\nRisk perception for COVID-19 infection categorised as risk perceived and risk not perceived.\n\nCompliance to public health and social measures (PHSMs) categorised as compliant; non-compliant and indifferent.\n\nComparison of frequencies during both waves using \u03c72 statistic to test for associations. Univariate and multivariate logistic regression analyses helped estimate the unadjusted and adjusted odds of risk perception of oneself contracting COVID-19. Level of statistical significance was set at p<0.05.\n\nTriangulated datasets had a total of 6401 respondents, majority (49.5%) aged 25-35 years. Overall, 55.4% and 56.1% perceived themselves to be at risk of COVID-19 infection during the W1 and W2, respectively. A higher proportion of males than females perceived themselves to be at risk during the W1 (60.3% vs 50.3%, p<0.001) and the W2 (58.3% vs 52.6%, p<0.05). Residing in the south-west was associated with not perceiving oneself at risk of COVID-19 infection (W1-AOdds Ratio (AOR) 0.28; 95% CI 0.20 to 0.40; W2-AOR 0.71; 95% CI 0.52 to 0.97). There was significant increase in non-compliance to PHSMs in the W2 compared with W1. Non-compliance rate was higher among individuals who perceived themselves not to be at risk of getting infected (p<0.001).\n\nRisk communication and community engagement geared towards increasing risk perception of COVID-19 should be implemented, particularly among the identified population groups. This could increase adherence to PHSMs and potentially reduce the burden of COVID-19 in Nigeria.", "doi": "10.1136/bmjopen-2021-058747", "pmid": "35365542", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-058747"}], "notes": [], "created": "2022-04-04T06:23:51.989Z", "modified": "2022-04-04T06:24:14.801Z"}, {"entity": "publication", "iuid": "c14bd0e3ce4b4000bd392cb482fb2de7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c14bd0e3ce4b4000bd392cb482fb2de7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c14bd0e3ce4b4000bd392cb482fb2de7"}}, "title": "Factors associated with physical activity reduction in Swedish older adults during the first COVID-19 outbreak: a longitudinal population-based study.", "authors": [{"family": "Sj\u00f6berg", "given": "Linnea", "initials": "L", "orcid": "0000-0002-1621-1174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20688dd7e9de43798d5261b9f1e227cf.json"}}, {"family": "Triolo", "given": "Federico", "initials": "F"}, {"family": "Saadeh", "given": "Marguerita", "initials": "M"}, {"family": "Dekhtyar", "given": "Serhiy", "initials": "S"}, {"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A"}, {"family": "Welmer", "given": "Anna-Karin", "initials": "AK"}], "type": "journal article", "published": "2022-04-01", "journal": {"title": "Eur Rev Aging Phys Act", "issn": "1813-7253", "volume": "19", "issue": "1", "pages": "9", "issn-l": null}, "abstract": "Physical activity (PA) decreased during the COVID-19 pandemic, especially among older adults, potentially leading to adverse consequences for their health. However, factors associated with reductions of PA during the pandemic have not been examined in a population-based sample of older adults. Thus, the aim of this study was to explore the association of pre-pandemic physical, mental, social and lifestyle factors with reductions in PA in older adults during the first wave of COVID-19, and whether the associations differed by age and sex.\n\nA population-based sample of 624 participants aged 65-99 years were identified from the Swedish National study on Aging and Care in Kungsholmen (SNAC-K) COVID19 Study. Information on pre-pandemic factors was collected through clinical examinations, interviews, and self-administered questionnaires in 2016-2019. Changes in light and intense PA during the first wave of the pandemic (May-September 2020) were self-reported. Data were analyzed using multiple logistic regression models, stratified by age (<70 vs. >80 years) and sex.\n\nThere was an association between pre-pandemic levels of higher depressive symptom burden (Odds Ratio (OR): 2.6, 95% Confidence Interval (CI): 1.1-6.4, <70 years), and impaired balance (OR: 1.7, 95% CI: 1.0-2.8, >80 years old) with reductions in light-intensity PA. Furthermore, the presence of musculoskeletal disease (OR: 1.8, 95% CI: 1.1-2.9, <70 years; OR: 2.3, 95% CI: 1.2-4.4, men), moderate/high levels of neuroticism (OR: 1.6, 95% CI: 1.0-2.6, <70 years; OR: 2.2, 95% CI: 1.3-3.5, women), and poor levels of social support (OR: 2.2, 95% CI: 1.2-4.3, >80 years) were related to reductions in higher-intensity PA. Those who were current smokers (OR: 0.3, 95% CI: 0.1-0.8, <70 years; OR: 0.2, 95% CI: 0.06-0.7, women), or had impaired balance (OR: 0.4, 95% CI: 0.2-0.8, >80 years) were less likely to reduce their levels of higher-intensity PA.\n\nFor future pandemics or waves of COVID-19, development of strategies is warranted for older individuals with psychiatric- or physical illness/dysfunction, as well as those with poor social support to counteract reductions in physical activities.", "doi": "10.1186/s11556-022-00287-z", "pmid": "35365065", "labels": {"Type: Journal article": null, "Topics: Register-based research": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s11556-022-00287-z"}], "notes": [], "created": "2022-04-04T06:24:35.714Z", "modified": "2022-04-04T06:24:35.794Z"}, {"entity": "publication", "iuid": "e145bce692554da09fd3e92b3da5536e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e145bce692554da09fd3e92b3da5536e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e145bce692554da09fd3e92b3da5536e"}}, "title": "Facilitators and barriers for effective staff work in Swedish National governmental crisis response to the COVID-19 pandemic.", "authors": [{"family": "Westman", "given": "Anja", "initials": "A", "orcid": "0000-0002-2794-5026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8650cc30d2a14d79aa16b2e4a3024fe2.json"}}, {"family": "Hugelius", "given": "Karin", "initials": "K", "orcid": "0000-0003-0534-4593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f7d4e9ff0f645598a2473e42806066a.json"}}, {"family": "Weinstein", "given": "Eric", "initials": "E", "orcid": "0000-0002-1147-5656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e061be2d669425e9d462d75d69832ad.json"}}, {"family": "Kurland", "given": "Lisa", "initials": "L"}], "type": "journal article", "published": "2022-04-01", "journal": {"title": "Disaster Med Public Health Prep", "issn": "1938-744X", "pages": "1-16", "issn-l": "1935-7893"}, "abstract": "The COVID-19 crisis response in Sweden was managed foremost by a collaboration of several national agencies. Normally their strategical and operational collaboration is limited, but the pandemic required new and unfamiliar collaborations.\n\nThis study aimed to clarify the facilitators and barriers of perceived effective staff work within and between four national agencies.\n\nA qualitative study of 10 participants with leading roles within the four national agencies' crisis organization, recruited via snowball sampling. The interviews were conducted between August - November 2020 and analyzed using content analysis.\n\nFour categories emerged from the analysis: individual characteristics; intra-agency organization; interorganizational collaboration and governmental directives. Subcategories crystalized from the data were analyzed and divided into factors facilitating or to function as barriers for effective staff work.\n\nIndividual factors such as attitude and approach were important for perceived effective staff work as well as clear mandates and structure of the organization. Barriers for perceived effective staff work includes lack of network, the complexity of the mission and organizational structures as well as lack of preparations and unclear mandates. Although flexibility and adaptability are necessary, they cannot always be planned, but be incorporated indirectly by selecting suitable individuals and optimizing organizational planning.", "doi": "10.1017/dmp.2022.91", "pmid": "35362402", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S193578932200091X"}], "notes": [], "created": "2022-04-04T06:32:24.772Z", "modified": "2022-04-04T06:32:24.868Z"}, {"entity": "publication", "iuid": "9cda8b3c808c40ca99fdaa75eafc009e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9cda8b3c808c40ca99fdaa75eafc009e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9cda8b3c808c40ca99fdaa75eafc009e"}}, "title": "Colon cancer treatment in Sweden during the COVID-19 pandemic: a nationwide register-based study.", "authors": [{"family": "Ekl\u00f6v", "given": "Karolina", "initials": "K", "orcid": "0000-0001-5059-5856", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49b27fb96266496d8561f6c0869da3f6.json"}}, {"family": "Nygren", "given": "Jonas", "initials": "J"}, {"family": "Bringman", "given": "Sven", "initials": "S"}, {"family": "L\u00f6fgren", "given": "Jenny", "initials": "J"}, {"family": "Sj\u00f6vall", "given": "Annika", "initials": "A"}, {"family": "Nordenvall", "given": "Caroline", "initials": "C"}, {"family": "Everhov", "given": "\u00c5sa H", "initials": "\u00c5H"}], "type": "journal article", "published": "2022-04-01", "journal": {"title": "Colorectal Dis", "issn": "1463-1318", "issn-l": null}, "abstract": "The COVID-19 pandemic has reduced the capacity to diagnose and treat cancer worldwide due to the prioritization of COVID-19 treatment.\n\nTo investigate treatment and outcomes of colon cancer in Sweden before and during the COVID-19 pandemic.\n\nIn an observational study, using the Swedish Colorectal Cancer Registry, we included (i) all Swedish patients diagnosed with colon cancer, and (ii) all patients undergoing surgery for colon cancer, in 2016-2020. Incidence of colon cancer, treatments and outcomes in 2020 were compared with 2019.\n\nThe number of colon cancer cases in Sweden in April-May 2020 was 27% lower than the previous year, whereas no difference was observed on an annual level (4589 vs 4763 patients (-4%)). Among patients with colon cancer undergoing surgery in 2020, the proportion resections was 93% vs 94% in 2019, with no increase in acute resections. Time from diagnosis to elective surgery decreased (29 days vs 33 days in 2020 vs 2019). In 2020, more patients underwent a 2-stage procedure with a diverting stoma as first surgery (6.1%) vs (4.4%) in 2019 (p=0.0020) and more patients were treated with preoperative chemotherapy (5.1%) vs (3,5%) 2019 (p= 0.0016). The proportion of patients that underwent laparoscopic surgery increased from 54% to 58% (p=0.0017) There were no differences in length of stay, surgical complications, reoperation, ICU-stay or 30-day mortality between the years.\n\nBased on nationwide annual data, we did not observe adverse effects of the COVID-19 pandemic on colon cancer treatment and short time outcomes in Sweden.", "doi": "10.1111/codi.16129", "pmid": "35362199", "labels": {"Category: Health": null, "Type: Journal article": null, "Topics: Register-based research": null}, "xrefs": [], "notes": [], "created": "2022-04-04T06:32:46.143Z", "modified": "2022-04-04T06:32:46.195Z"}, {"entity": "publication", "iuid": "5fec314aa8ce47189a0984489f9241b5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5fec314aa8ce47189a0984489f9241b5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5fec314aa8ce47189a0984489f9241b5"}}, "title": "The social patterning of Covid-19 vaccine uptake in older adults: A register-based cross-sectional study in Sweden.", "authors": [{"family": "Spetz", "given": "Malin", "initials": "M"}, {"family": "Lundberg", "given": "Lisa", "initials": "L"}, {"family": "Nwaru", "given": "Chioma", "initials": "C"}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Hammar", "given": "Niklas", "initials": "N"}, {"family": "Rosvall", "given": "Maria", "initials": "M"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "15", "pages": "100331", "issn-l": null}, "abstract": "A broad vaccination coverage is crucial for preventing the spread of Covid-19 and reduce serious illness or death. The aim of this study was to examine social inequalities in Covid-19 vaccination uptake as of 17th May 2021 among Swedish adults aged \u2265 60 years.\n\nThe study population comprised a general population cohort aged 60 years or older (n = 350,805), representative of the Swedish population. Data were collected through the nationwide linked multi-register observational study SCIFI-PEARL, and associations between sociodemographic determinants and Covid-19 vaccination uptake were analysed using logistic regression. Intersectional analyses of sociodemographic heterogeneity were performed by taking several overlapping social dimensions into account. Data availability extended to 17 May 2021.\n\nThe overall vaccination coverage was 87\u00b72% by 17th May 2021. Younger age, male sex, lower income, living alone, and being born outside Sweden, were all associated with a lower uptake of vaccination. The lowest Covid-19 vaccination uptake was seen in individuals born in low-or middle-income countries, of which only 60% had received vaccination, with an odds ratio (OR) of not being vaccinated of 6\u00b705 (95% CI: 5\u00b785-6\u00b726) compared to individuals born in Sweden. These associations persisted after adjustments for possible confounding factors. The intersectional analyses showed even larger variations in vaccination in cross-classified sociodemographic subgroups (ranging from 44% to 97%) with marked differences in uptake of vaccination within sociodemographic groups.\n\nThe uptake of Covid-19 vaccine during the spring of 2021 in Sweden varied substantially both between and within sociodemographic groups. The use of an intersectional approach, taking several overlapping social dimensions into account at the same time rather than only using one-dimensional measures, contributes to a better understanding of the complexity in the uptake of vaccination.\n\nSciLifeLab / Knut & Alice Wallenberg Foundation, Swedish Research Council, Swedish government ALF-agreement, FORMAS.", "doi": "10.1016/j.lanepe.2022.100331", "pmid": "35252941", "labels": {"Research Area: Vaccine": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Health": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC8881226"}, {"db": "pii", "key": "S2666-7762(22)00024-2"}], "notes": [], "created": "2022-11-29T14:27:55.286Z", "modified": "2022-11-29T14:27:55.300Z"}, {"entity": "publication", "iuid": "ed71d308d25d45d4a52a25812056550f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed71d308d25d45d4a52a25812056550f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed71d308d25d45d4a52a25812056550f"}}, "title": "The effect of the COVID-19 pandemic on severe asthma care in Europe: will care change for good?", "authors": [{"family": "Eger", "given": "Katrien", "initials": "K", "orcid": "0000-0002-9628-2174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ec87651e0164ace9872a7186867fa83.json"}}, {"family": "Paroczai", "given": "Dora", "initials": "D"}, {"family": "Bacon", "given": "Alison", "initials": "A", "orcid": "0000-0003-4279-3814", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b6040010eb24885832dc5ed684e7cfc.json"}}, {"family": "Schleich", "given": "Florence", "initials": "F"}, {"family": "Sergejeva", "given": "Svetlana", "initials": "S"}, {"family": "Bourdin", "given": "Arnaud", "initials": "A", "orcid": "0000-0002-4645-5209", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f88bf68759c246f3a1a7df2749bf606c.json"}}, {"family": "Vachier", "given": "Isabelle", "initials": "I"}, {"family": "Zervas", "given": "Eleftherios", "initials": "E", "orcid": "0000-0001-7436-4550", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0d338ea2b724ccab920b95ae3c42ffe.json"}}, {"family": "Katsoulis", "given": "Konstantinos", "initials": "K"}, {"family": "Papapetrou", "given": "Dimosthenis", "initials": "D"}, {"family": "Kostikas", "given": "Konstantinos", "initials": "K", "orcid": "0000-0003-0774-3942", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3eaa831d14b14f5e9188d8f05ede185f.json"}}, {"family": "Csoma", "given": "Zsuzsanna", "initials": "Z"}, {"family": "Heffler", "given": "Enrico", "initials": "E"}, {"family": "Canonica", "given": "Giorgio Walter", "initials": "GW", "orcid": "0000-0001-8467-2557", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ccaf06bd57b438fabe0a7c904259881.json"}}, {"family": "Grisle", "given": "Ineta", "initials": "I"}, {"family": "Bieksiene", "given": "Kristina", "initials": "K"}, {"family": "Palacionyte", "given": "Jolita", "initials": "J"}, {"family": "Ten Brinke", "given": "Anneke", "initials": "A"}, {"family": "Hashimoto", "given": "Simone", "initials": "S", "orcid": "0000-0001-8995-3817", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5d3f0acc6674d52bd765e2c0e58f4e1.json"}}, {"family": "Smeenk", "given": "Frank W J M", "initials": "FWJM"}, {"family": "Braunstahl", "given": "Gert-Jan", "initials": "GJ", "orcid": "0000-0001-7671-3742", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/129b78ac29b44216a8f4267281441349.json"}}, {"family": "van der Sar", "given": "Simone", "initials": "S"}, {"family": "Mih\u0103l\u0163an", "given": "Florin", "initials": "F"}, {"family": "Nenasheva", "given": "Natalia", "initials": "N"}, {"family": "Peredelskaya", "given": "Marina", "initials": "M"}, {"family": "Zvezdin", "given": "Biljana", "initials": "B"}, {"family": "\u010cekerevac", "given": "Ivan", "initials": "I"}, {"family": "Hromi\u0161", "given": "Sanja", "initials": "S"}, {"family": "\u0106upurdija", "given": "Vojislav", "initials": "V"}, {"family": "Lazic", "given": "Zorica", "initials": "Z"}, {"family": "Milenkovic", "given": "Branislava", "initials": "B"}, {"family": "Dimic-Janjic", "given": "Sanja", "initials": "S"}, {"family": "Yasinska", "given": "Valentyna", "initials": "V"}, {"family": "Dahl\u00e9n", "given": "Barbro", "initials": "B"}, {"family": "Bossios", "given": "Apostolos", "initials": "A", "orcid": "0000-0002-0494-2690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/494bc3af38b0417186d9444f1ee3fa97.json"}}, {"family": "Lazarinis", "given": "Nikolaos", "initials": "N"}, {"family": "Aronsson", "given": "David", "initials": "D"}, {"family": "Egesten", "given": "Arne", "initials": "A"}, {"family": "Munir", "given": "Abul Kashem Mohammad", "initials": "AKM"}, {"family": "Ahlbeck", "given": "Lars", "initials": "L"}, {"family": "Janson", "given": "Christer", "initials": "C", "orcid": "0000-0001-5093-6980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba296cda8ef74430ad5457e71b7dae94.json"}}, {"family": "\u0160krgat", "given": "Sabina", "initials": "S"}, {"family": "Edelbaher", "given": "Natalija", "initials": "N"}, {"family": "Leuppi", "given": "Joerg", "initials": "J"}, {"family": "Jaun", "given": "Fabienne", "initials": "F"}, {"family": "R\u00fcdiger", "given": "Jochen", "initials": "J"}, {"family": "Pavlov", "given": "Nikolay", "initials": "N"}, {"family": "Gianella", "given": "Pietro", "initials": "P"}, {"family": "Fischer", "given": "Reta", "initials": "R"}, {"family": "Charbonnier", "given": "Florian", "initials": "F"}, {"family": "Chaudhuri", "given": "Rekha", "initials": "R"}, {"family": "Smith", "given": "Steven James", "initials": "SJ"}, {"family": "Doe", "given": "Simon", "initials": "S"}, {"family": "Fawdon", "given": "Michelle", "initials": "M"}, {"family": "Masoli", "given": "Matthew", "initials": "M", "orcid": "0000-0003-0909-0148", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83de342198de485ea699edc035980c3c.json"}}, {"family": "Heaney", "given": "Liam", "initials": "L"}, {"family": "Haitchi", "given": "Hans Michael", "initials": "HM", "orcid": "0000-0001-8603-302X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6de760fa29414bf399a0a03e50ddc057.json"}}, {"family": "Kurukulaaratchy", "given": "Ramesh", "initials": "R"}, {"family": "Fulton", "given": "Olivia", "initials": "O", "orcid": "0000-0001-7358-0219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/707e706c3f8149e4aa9a8009017d0028.json"}}, {"family": "Frankem\u00f6lle", "given": "Betty", "initials": "B"}, {"family": "Gibson", "given": "Toni", "initials": "T", "orcid": "0000-0001-8684-8624", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e804ad5e718648acaddacf249d414ae2.json"}}, {"family": "Needham", "given": "Karen", "initials": "K"}, {"family": "Howarth", "given": "Peter", "initials": "P", "orcid": "0000-0003-0619-7927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ac4536cccd642efa26db94364dceac2.json"}}, {"family": "Djukanovic", "given": "Ratko", "initials": "R"}, {"family": "Bel", "given": "Elisabeth", "initials": "E"}, {"family": "Hyland", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "ERJ Open Res", "issn": "2312-0541", "volume": "8", "issue": "2", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has put pressure on healthcare services, forcing the reorganisation of traditional care pathways. We investigated how physicians taking care of severe asthma patients in Europe reorganised care, and how these changes affected patient satisfaction, asthma control and future care.\n\nIn this European-wide cross-sectional study, patient surveys were sent to patients with a physician-diagnosis of severe asthma, and physician surveys to severe asthma specialists between November 2020 and May 2021.\n\n1101 patients and 268 physicians from 16 European countries contributed to the study. Common physician-reported changes in severe asthma care included use of video/phone consultations (46%), reduced availability of physicians (43%) and change to home-administered biologics (38%). Change to phone/video consultations was reported in 45% of patients, of whom 79% were satisfied or very satisfied with this change. Of 709 patients on biologics, 24% experienced changes in biologic care, of whom 92% were changed to home-administered biologics and of these 62% were satisfied or very satisfied with this change. Only 2% reported worsening asthma symptoms associated with changes in biologic care. Many physicians expect continued implementation of video/phone consultations (41%) and home administration of biologics (52%).\n\nChange to video/phone consultations and home administration of biologics was common in severe asthma care during the COVID-19 pandemic and was associated with high satisfaction levels in most but not all cases. Many physicians expect these changes to continue in future severe asthma care, though satisfaction levels may change after the pandemic.", "doi": "10.1183/23120541.00065-2022", "pmid": "35582679", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00065-2022"}, {"db": "pmc", "key": "PMC8994963"}], "notes": [], "created": "2022-06-21T18:03:14.205Z", "modified": "2022-06-21T18:03:33.900Z"}, {"entity": "publication", "iuid": "b9884b197f3146b0aabf7d635fbd8ab2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9884b197f3146b0aabf7d635fbd8ab2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9884b197f3146b0aabf7d635fbd8ab2"}}, "title": "Short-term rental market crisis management during the COVID-19 pandemic: Stakeholders' perspectives.", "authors": [{"family": "Miguel", "given": "Cristina", "initials": "C"}, {"family": "Pechurina", "given": "Anna", "initials": "A"}, {"family": "Kirkulak-Uludag", "given": "Berna", "initials": "B"}, {"family": "Drotarova", "given": "Maria Hadjielia", "initials": "MH"}, {"family": "Duman\u010di\u0107", "given": "Kosjenka", "initials": "K"}, {"family": "Braje", "given": "Ivana Na\u010dinovi\u0107", "initials": "IN"}, {"family": "Giglio", "given": "Carlo", "initials": "C"}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Int J Hosp Manag", "issn": "0278-4319", "issn-l": null, "volume": "102", "issue": null, "pages": "103147"}, "abstract": "Contingency plans and crisis management strategies have been implemented by the short-term rental industry to deal with the COVID-19 pandemic. This paper examines the strategies adopted by three key groups of stakeholders: short-term rental platforms (e.g. Airbnb, Booking.com), service providers (represented by property management companies and short-term rental associations) and policymakers/tourism experts. The professional service providers, in particular, constitute a significant share of the short-term rental industry, but have not received much scholarly attention. In this respect, our study fills this gap by bringing attention to unexplored segments of the short-term rental industry. By examining and comparing the responses from these key groups, the paper contributes to the ongoing research about the workings of the short-term rental industry and its responses to the COVID-19 crisis.", "doi": "10.1016/j.ijhm.2022.103147", "pmid": "35035022", "labels": {"Topics: Register-based research": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0278-4319(22)00009-3"}, {"db": "pmc", "key": "PMC8752289"}], "notes": [], "created": "2022-01-27T07:40:12.388Z", "modified": "2022-11-22T05:38:29.271Z"}, {"entity": "publication", "iuid": "98335ad0296a4ef6a2c0ac2bebc0ae7b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/98335ad0296a4ef6a2c0ac2bebc0ae7b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/98335ad0296a4ef6a2c0ac2bebc0ae7b"}}, "title": "Prevention of Recurrent Childhood Caries with Probiotic Supplements: A Randomized Controlled Trial with a 12-Month Follow-Up.", "authors": [{"family": "Hassl\u00f6f", "given": "P", "initials": "P", "orcid": "0000-0002-7670-3103", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41a254437667432fb88ce0f53d350059.json"}}, {"family": "Granqvist", "given": "L", "initials": "L"}, {"family": "Stecks\u00e9n-Blicks", "given": "C", "initials": "C"}, {"family": "Twetman", "given": "S", "initials": "S"}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Probiotics Antimicrob Proteins", "issn": "1867-1314", "volume": "14", "issue": "2", "pages": "384-390", "issn-l": null}, "abstract": "The aim of this study was to evaluate the effect of drops containing probiotic bacteria on the recurrence of dental caries in preschool children. The study employed a randomized, placebo-controlled, double-blinded design with two parallel arms. 38 preschool children were enrolled after comprehensive restorative treatment under general anesthesia or conscious sedation (baseline), and they were followed up after 6 and 12 months. Parents of children in the test group were instructed to give 5 daily drops containing two strains of Limosilactobacillus reuteri (DSM 17938 and ATCC PTA 5289) at bedtime. The placebo drops were identically composed but lacked bacteria. The duration of the intervention was 12 months. The primary endpoint was recurrence of new caries lesions on subject level (yes/no), and secondary endpoints were presence of dental plaque and gingivitis. We found high rate of recurrent moderate and extensive lesions after 12 months (67%) but there were no significant differences between the groups. We observed no beneficial effects on dental plaque or gingival inflammation. The findings were however uncertain and inconclusive due to lack of power, a consequence of the COVID-19 pandemic. ClinTrials.gov Identifier: (NCT04929340), June 18, 2021; retrospectively registered.", "doi": "10.1007/s12602-022-09913-9", "pmid": "35083729", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s12602-022-09913-9"}, {"db": "pmc", "key": "PMC8791080"}, {"db": "ClinicalTrials.gov", "key": "NCT04929340"}], "notes": [], "created": "2022-01-31T11:47:22.815Z", "modified": "2022-06-21T18:22:19.051Z"}, {"entity": "publication", "iuid": "9c92fc99dc4e4140973b314269871fb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9c92fc99dc4e4140973b314269871fb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9c92fc99dc4e4140973b314269871fb1"}}, "title": "Preterm birth after the introduction of COVID-19 mitigation measures in Norway, Sweden, and Denmark: a registry-based difference-in-differences study.", "authors": [{"family": "Oakley", "given": "Laura L", "initials": "LL"}, {"family": "\u00d6rtqvist", "given": "Anne K", "initials": "AK"}, {"family": "Kinge", "given": "Jonas", "initials": "J"}, {"family": "Hansen", "given": "Anne Vinkel", "initials": "AV"}, {"family": "Petersen", "given": "Tanja Gram", "initials": "TG"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Telle", "given": "Kjetil E", "initials": "KE"}, {"family": "Magnus", "given": "Maria C", "initials": "MC"}, {"family": "Mortensen", "given": "Laust Hvas", "initials": "LH"}, {"family": "Nybo Andersen", "given": "Anne-Marie", "initials": "AM"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Am J Obstet Gynecol", "issn": "1097-6868", "volume": "226", "issue": "4", "pages": "550.e1-550.e22", "issn-l": null}, "abstract": "Although some studies have reported a decrease in preterm birth following the start of the COVID-19 pandemic, the findings are inconsistent.\n\nThis study aimed to compare the incidences of preterm birth before and after the introduction of COVID-19 mitigation measures in Scandinavian countries using robust population-based registry data.\n\nThis was a registry-based difference-in-differences study using births from January 2014 through December 2020 in Norway, Sweden, and Denmark. The changes in the preterm birth (<37 weeks) rates before and after the introduction of COVID-19 mitigation measures (set to March 12, 2020) were compared with the changes in preterm birth before and after March 12 from 2014 to 2019. The differences per 1000 births were calculated for 2-, 4-, 8-, 12-, and 16-week intervals before and after March 12. The secondary analyses included medically indicated preterm birth, spontaneous preterm birth, and very preterm (<32 weeks) birth.\n\nA total of 1,519,521 births were included in this study. During the study period, 5.6% of the births were preterm in Norway and Sweden, and 5.7% were preterm in Denmark. There was a seasonal variation in the incidence of preterm birth, with the highest incidence during winter. In all the 3 countries, there was a slight overall decline in preterm births from 2014 to 2020. There was no consistent evidence of a change in the preterm birth rates following the introduction of COVID-19 mitigation measures, with difference-in-differences estimates ranging from 3.7 per 1000 births (95% confidence interval, -3.8 to 11.1) for the first 2 weeks after March 12, 2020, to -1.8 per 1000 births (95% confidence interval, -4.6 to 1.1) in the 16 weeks after March 12, 2020. Similarly, there was no evidence of an impact on medically indicated preterm birth, spontaneous preterm birth, or very preterm birth.\n\nUsing high-quality national data on births in 3 Scandinavian countries, each of which implemented different approaches to address the pandemic, there was no evidence of a decline in preterm births following the introduction of COVID-19 mitigation measures.", "doi": "10.1016/j.ajog.2021.11.034", "pmid": "34774824", "labels": {"Category: Public Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8648397"}, {"db": "pii", "key": "S0002-9378(21)01231-X"}], "notes": [], "created": "2021-11-26T14:28:58.085Z", "modified": "2023-01-13T14:47:21.250Z"}, {"entity": "publication", "iuid": "31e069a32bd145999c09803302272995", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/31e069a32bd145999c09803302272995.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/31e069a32bd145999c09803302272995"}}, "title": "Patient and public involvement in the build-up of COVID-19 testing in Sweden.", "authors": [{"family": "Fredriksson", "given": "Mio", "initials": "M", "orcid": "0000-0002-3858-3454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f57456b169b544b2889ddf447163756b.json"}}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Health Expect", "issn": "1369-7625", "volume": "25", "issue": "2", "pages": "541-548", "issn-l": null}, "abstract": "Patient and public involvement in healthcare can be particularly challenging during crises such as the COVID-19 pandemic.\n\nThe aims of the study, which focuses on COVID-19 testing in Sweden, were to explore (1) how, or to what extent, patients and members of the public were involved in decisions about the organization of COVID-19 testing during the first year of pandemic and (2) whether this was seen as feasible or desirable by regional and national stakeholders.\n\nA qualitative interview study was conducted with key organizational stakeholders at three national agencies and within three Swedish regions (n = 16).\n\nThere had been no patient and public involvement activities in the area of COVID-19 testing. The regions had, however, tried to respond to demands or critiques from patients and the public along the way and to adapt the services to respond to their preferences. The need for rapid decision-making, the uncertainty about whom to involve, as well as a hesitation about the appropriateness of involving patients and the public contributed to the lack of involvement.\n\nFuture studies on patient and public involvement during crises should address what structures need to be in place to carry out involvement successfully during crises and when to use activities with varying degrees of power or decision-making authority for patients and members of the public.\n\nFifteen members of the public contributed with short reflections on the study findings.", "doi": "10.1111/hex.13463", "pmid": "35257448", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8957722"}], "notes": [], "created": "2023-01-13T13:32:28.458Z", "modified": "2023-01-13T13:32:28.510Z"}, {"entity": "publication", "iuid": "763b1af1aa094b39ac60e0090b487a6b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/763b1af1aa094b39ac60e0090b487a6b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/763b1af1aa094b39ac60e0090b487a6b"}}, "title": "Modeling COVID-19 Mortality Across 44 Countries: Face Covering May Reduce Deaths.", "authors": [{"family": "Motallebi", "given": "Sahar", "initials": "S"}, {"family": "Cheung", "given": "Rex C Y", "initials": "RCY"}, {"family": "Mohit", "given": "Babak", "initials": "B"}, {"family": "Shahabi", "given": "Shahram", "initials": "S"}, {"family": "Alishahi Tabriz", "given": "Amir", "initials": "A"}, {"family": "Moattari", "given": "Syamak", "initials": "S"}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Am J Prev Med", "issn": "1873-2607", "volume": "62", "issue": "4", "pages": "483-491", "issn-l": null}, "abstract": "Despite ongoing efforts to vaccinate communities against COVID-19, the necessity of face mask use in controlling the pandemic remains subject to debate. Several studies have investigated face masks and COVID-19, covering smaller and less diverse populations than this study's sample. This study examines a hypothesized association of face-covering mandates with COVID-19 mortality decline across 44 countries in 2 continents.\n\nIn a retrospective cohort study, changes in COVID-19\u2012related daily mortality rate per million population from February 15 to May 31, 2020 were compared between 27 countries with and 17 countries without face mask mandates in nearly 1 billion (911,446,220 total) people. Longitudinal mixed effect modeling was applied and adjusted for over 10 relevant demographic, social, clinical, and time-dependent confounders.\n\nAverage COVID-19 mortality per million was 288.54 in countries without face mask policies and 48.40 in countries with face mask policies. In no mask countries, adjusted average daily increase was 0.1553 - 0.0017 X (days since the first case) log deaths per million, compared with 0.0900 - 0.0009 X (days since the first case) log deaths per million in the countries with a mandate. A total of 60 days into the pandemic, countries without face mask mandates had an average daily increase of 0.0533 deaths per million, compared with the average daily increase of 0.0360 deaths per million for countries with face mask mandates.\n\nThis study's significant results show that face mask mandates were associated with lower COVID-19 deaths rates than the rates in countries without mandates. These findings support the use of face masks to prevent excess COVID-19 deaths and should be advised during airborne disease epidemics.", "doi": "10.1016/j.amepre.2021.09.019", "pmid": "35305777", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0749-3797(21)00557-2"}, {"db": "pmc", "key": "PMC8580811"}], "notes": [], "created": "2022-03-23T06:16:41.748Z", "modified": "2022-04-04T07:12:28.738Z"}, {"entity": "publication", "iuid": "c57b1b3cc1e24d3e85c9a87cf3771051", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c57b1b3cc1e24d3e85c9a87cf3771051.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c57b1b3cc1e24d3e85c9a87cf3771051"}}, "title": "Long-term SARS-CoV-2-specific and cross-reactive cellular immune responses correlate with humoral responses, disease severity, and symptomatology.", "authors": [{"family": "Laur\u00e9n", "given": "Ida", "initials": "I", "orcid": "0000-0003-0041-6084", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76b14e85b56d4c898ad853659043b3b2.json"}}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/305bca9e5c6c423898c272bf06ce2f2a.json"}}, {"family": "Lord", "given": "Martin", "initials": "M"}, {"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Gabrielsson", "given": "Lena", "initials": "L"}, {"family": "Chourlia", "given": "Aikaterini", "initials": "A"}, {"family": "Amo\u00eado-Leite", "given": "Catarina", "initials": "C"}, {"family": "Josyula", "given": "Vijay S", "initials": "VS"}, {"family": "Eltahir", "given": "Mohamed", "initials": "M"}, {"family": "Kerzeli", "given": "Iliana", "initials": "I"}, {"family": "Falk", "given": "August J", "initials": "AJ", "orcid": "0000-0002-7773-1851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40d944d7fa964f4292f10012356a2730.json"}}, {"family": "Hober", "given": "Jonathan", "initials": "J"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Wiberg", "given": "Anna", "initials": "A"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Tegel", "given": "Hanna", "initials": "H"}, {"family": "Burman", "given": "Joachim", "initials": "J"}, {"family": "Xu", "given": "Feifei", "initials": "F"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Christoffersson", "given": "Gustaf", "initials": "G"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Philipson", "given": "Mia", "initials": "M"}, {"family": "D\u00f6nnes", "given": "Pierre", "initials": "P"}, {"family": "Lindsay", "given": "Robin", "initials": "R"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Mangsbo", "given": "Sara", "initials": "S", "orcid": "0000-0002-1355-2678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cf494629d8a4f9584ada4be16dff66b.json"}}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Immun Inflamm Dis", "issn": "2050-4527", "issn-l": null, "volume": "10", "issue": "4", "pages": "e595"}, "abstract": "Cellular immune memory responses post coronavirus disease 2019 (COVID-19) have been difficult to assess due to the risks of contaminating the immune response readout with memory responses stemming from previous exposure to endemic coronaviruses. The work herein presents a large-scale long-term follow-up study investigating the correlation between symptomology and cellular immune responses four to five months post seroconversion based on a unique severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific peptide pool that contains no overlapping peptides with endemic human coronaviruses.\r\n\r\nPeptide stimulated memory T cell responses were assessed with dual interferon-gamma (IFN\u03b3) and interleukin (IL)-2 Fluorospot. Serological analyses were performed using a multiplex antigen bead array.\r\n\r\nOur work demonstrates that long-term SARS-CoV-2-specific memory T cell responses feature dual IFN\u03b3 and IL-2 responses, whereas cross-reactive memory T cell responses primarily generate IFN\u03b3 in response to SARS-CoV-2 peptide stimulation. T cell responses correlated to long-term humoral immune responses. Disease severity as well as specific COVID-19 symptoms correlated with the magnitude of the SARS-CoV-2-specific memory T cell response four to five months post seroconversion.\r\n\r\nUsing a large cohort and a SARS-CoV-2-specific peptide pool we were able to substantiate that initial disease severity and symptoms correlate with the magnitude of the SARS-CoV-2-specific memory T cell responses.", "doi": "10.1002/iid3.595", "pmid": "35349756", "labels": {"Category: Health": null, "Research Area: Vaccine": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Type: Journal article": null, "Research Area: High-throughput and high-content serology": null}, "xrefs": [], "notes": [], "created": "2022-02-06T17:26:54.809Z", "modified": "2022-10-13T13:02:04.664Z"}, {"entity": "publication", "iuid": "04e91ab5621d4bb2b45f259dc93181cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/04e91ab5621d4bb2b45f259dc93181cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/04e91ab5621d4bb2b45f259dc93181cf"}}, "title": "Experiences of children with disabilities during the COVID-19 pandemic in Sweden: a qualitative interview study.", "authors": [{"family": "F\u00e4ldt", "given": "Anna Erica", "initials": "AE", "orcid": "0000-0001-7257-8758", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96a1134c3b564ce1919f212eee8d6725.json"}}, {"family": "Klint", "given": "Filippa", "initials": "F"}, {"family": "Warner", "given": "Georgina", "initials": "G"}, {"family": "Sarkadi", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "BMJ Paediatr Open", "issn": "2399-9772", "volume": "6", "issue": "1", "issn-l": null}, "abstract": "The impact of the COVID-19 pandemic on people with disabilities has been described as a 'triple jeopardy'. Not only have they experienced the negative social impacts of disease control measures, but access to required health services has been affected, and, not least, they are at increased risk of severe outcomes from COVID-19. This study aimed to determine how children with disabilities have experienced the pandemic in Sweden and its impact on their lives.\n\nSix children (5-13 years) were interviewed via video conferencing. An interview guide was adapted based on the children's communicative abilities and included augmentative and alternative communication support. Reflective field notes were included in the analysis. The data were analysed using qualitative content analysis.\n\nTwo themes were identified: The child's knowledge of Corona raises anxiety and fear; and Boring Corona makes the child even lonelier. The children had knowledge about and were worried about COVID-19, primarily about illness and death of their grandparents. The children longed for their grandparents and other social contacts at school, and life was described as boring and lonely. Many families lacked adequate tools to communicate with their children about the pandemic.\n\nGiven adequate support, children with disabilities and communication difficulties can give insights to their unique life situations. The interviewed children reported significant impact on their life and school life. Children were worried about their grandparents based on their knowledge about the virus. The enthusiasm with which the children engaged in the interviews is testament to the need and right of all children, regardless of communicative competence, to voice their experiences.", "doi": "10.1136/bmjpo-2021-001398", "pmid": "36053617", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8983410"}, {"db": "pii", "key": "10.1136/bmjpo-2021-001398"}], "notes": [], "created": "2022-10-13T13:20:57.007Z", "modified": "2023-01-13T13:52:53.701Z"}, {"entity": "publication", "iuid": "07eaf63ecf5c47c7a76c49d678fa0c9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07eaf63ecf5c47c7a76c49d678fa0c9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07eaf63ecf5c47c7a76c49d678fa0c9c"}}, "title": "Amyloid processing in COVID\u201019\u2010associated neurological syndromes", "authors": [{"family": "Ziff", "given": "Oliver J", "initials": "OJ", "orcid": "0000-0002-1504-7245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e3814923cdb142d8b934538ba2ec107d.json"}}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0002-3579-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0ae25211e354556a737b1a23c53c6e1.json"}}, {"family": "Mehta", "given": "Puja R", "initials": "PR"}, {"family": "Brown", "given": "Rachel", "initials": "R"}, {"family": "Athauda", "given": "Dilan", "initials": "D"}, {"family": "Heaney", "given": "Judith", "initials": "J"}, {"family": "Heslegrave", "given": "Amanda J", "initials": "AJ"}, {"family": "Benedet", "given": "Andrea Lessa", "initials": "AL"}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/351fab09f6e24b9f9e6695da83947cb6.json"}}, {"family": "Checkley", "given": "Anna M", "initials": "AM"}, {"family": "Houlihan", "given": "Catherine F", "initials": "CF"}, {"family": "Gauthier", "given": "Serge", "initials": "S"}, {"family": "Rosa\u2010Neto", "given": "Pedro", "initials": "P"}, {"family": "Fox", "given": "Nick C", "initials": "NC"}, {"family": "Schott", "given": "Jonathan M", "initials": "JM"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e314740b02c344d2b336a9410e28041e.json"}}, {"family": "Benjamin", "given": "Laura A", "initials": "LA", "orcid": "0000-0002-9685-1664", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15ffcba9a1b94d2d9d33c533c03a23d5.json"}}, {"family": "Paterson", "given": "Ross W", "initials": "RW", "orcid": "0000-0001-9372-3635", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/953284bd6f6b4bcb8fa1bb46644357ed.json"}}], "type": "journal-article", "published": "2022-04-00", "journal": {"title": "J Neurochem", "issn": "0022-3042", "issn-l": null, "volume": "161", "issue": "2", "pages": "146-157"}, "abstract": "SARS-CoV-2 infection can damage the nervous system with multiple neurological manifestations described. However, there is limited understanding of the mechanisms underlying COVID-19 neurological injury. This is a cross-sectional exploratory prospective biomarker cohort study of 21 patients with COVID-19 neurological syndromes (Guillain-Barre Syndrome [GBS], encephalitis, encephalopathy, acute disseminated encephalomyelitis [ADEM], intracranial hypertension, and central pain syndrome) and 23 healthy COVID-19 negative controls. We measured cerebrospinal fluid (CSF) and serum biomarkers of amyloid processing, neuronal injury (neurofilament light), astrocyte activation (GFAp), and neuroinflammation (tissue necrosis factor [TNF] \u0251, interleukin [IL]-6, IL-1\u03b2, IL-8). Patients with COVID-19 neurological syndromes had significantly reduced CSF soluble amyloid precursor protein (sAPP)-\u0251 (p = 0.004) and sAPP\u03b2 (p = 0.03) as well as amyloid \u03b2 (A\u03b2) 40 (p = 5.2 \u00d7 10-8 ), A\u03b242 (p = 3.5 \u00d7 10-7 ), and A\u03b242/A\u03b240 ratio (p = 0.005) compared to controls. Patients with COVID-19 neurological syndromes showed significantly increased neurofilament light (NfL, p = 0.001) and this negatively correlated with sAPP\u0251 and sAPP\u03b2. Conversely, GFAp was significantly reduced in COVID-19 neurological syndromes (p = 0.0001) and this positively correlated with sAPP\u0251 and sAPP\u03b2. COVID-19 neurological patients also displayed significantly increased CSF proinflammatory cytokines and these negatively correlated with sAPP\u0251 and sAPP\u03b2. A sensitivity analysis of COVID-19-associated GBS revealed a non-significant trend toward greater impairment of amyloid processing in COVID-19 central than peripheral neurological syndromes. This pilot study raises the possibility that patients with COVID-19-associated neurological syndromes exhibit impaired amyloid processing. Altered amyloid processing was linked to neuronal injury and neuroinflammation but reduced astrocyte activation.", "doi": "10.1111/jnc.15585", "pmid": "35137414", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9115071"}], "notes": [], "created": "2022-02-11T10:25:39.664Z", "modified": "2023-06-19T07:47:56.235Z"}, {"entity": "publication", "iuid": "83e75c24a2244523a1c138ab61c9f01a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/83e75c24a2244523a1c138ab61c9f01a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/83e75c24a2244523a1c138ab61c9f01a"}}, "title": "Vaccine based on folded RBD-PreS fusion protein with potential to induce sterilizing immunity to SARS-CoV-2 variants.", "authors": [{"family": "Gattinger", "given": "Pia", "initials": "P", "orcid": "0000-0001-6724-8543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d470813c45d04ab295b0df1b02d7cf93.json"}}, {"family": "Kratzer", "given": "Bernhard", "initials": "B", "orcid": "0000-0003-1091-4327", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dde68da106534c85a2fdba7bf06ce4ee.json"}}, {"family": "Tulaeva", "given": "Inna", "initials": "I", "orcid": "0000-0002-5825-2687", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34ba6b200b4540579cc8f5d732832076.json"}}, {"family": "Niespodziana", "given": "Katarzyna", "initials": "K", "orcid": "0000-0003-0700-965X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f98f53416c6439f87513dd4915f2a32.json"}}, {"family": "Ohradanova-Repic", "given": "Anna", "initials": "A", "orcid": "0000-0002-8005-8522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05059e6a105642238652352cc49b5a8b.json"}}, {"family": "Gebetsberger", "given": "Laura", "initials": "L", "orcid": "0000-0002-6480-6228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/397733c00f074e479edb225c45a62363.json"}}, {"family": "Borochova", "given": "Kristina", "initials": "K"}, {"family": "Garner-Spitzer", "given": "Erika", "initials": "E", "orcid": "0000-0002-5283-0458", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/439c4225d3da443d91bb45cb87436042.json"}}, {"family": "Trapin", "given": "Doris", "initials": "D"}, {"family": "Hofer", "given": "Gerhard", "initials": "G"}, {"family": "Keller", "given": "Walter", "initials": "W", "orcid": "0000-0002-2261-958X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24a27b24c2ad4b1883a0805fd97f0b58.json"}}, {"family": "Baumgartner", "given": "Isabella", "initials": "I"}, {"family": "Tancevski", "given": "Ivan", "initials": "I", "orcid": "0000-0001-5116-8960", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb82e679725d48748424895e3fef8fa8.json"}}, {"family": "Khaitov", "given": "Musa", "initials": "M", "orcid": "0000-0003-4961-9640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d6ec5145c294afaac62bef394042c9f.json"}}, {"family": "Karaulov", "given": "Alexander", "initials": "A"}, {"family": "Stockinger", "given": "Hannes", "initials": "H", "orcid": "0000-0001-6404-4430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/134cb6399ed043879f4f834914429698.json"}}, {"family": "Wiedermann", "given": "Ursula", "initials": "U", "orcid": "0000-0002-1302-3223", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ecada0958ed84f0186e48880c874ad07.json"}}, {"family": "Pickl", "given": "Winfried F", "initials": "WF", "orcid": "0000-0003-0430-4952", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/efd20aea311c46f7ad4a2930a5308a8c.json"}}, {"family": "Valenta", "given": "Rudolf", "initials": "R", "orcid": "0000-0001-5944-3365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46fbb364a1fd41c4a2d48836789dfd4c.json"}}], "type": "journal article", "published": "2022-03-31", "journal": {"title": "Allergy", "issn": "1398-9995", "issn-l": "0105-4538"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing global COVID-19 pandemic. One possibility to control the pandemic is to induce sterilizing immunity through the induction and maintenance of neutralizing antibodies preventing SARS-CoV-2 from entering human cells to replicate in.\n\nWe report the construction and in vitro and in vivo characterization of a SARS-CoV-2 subunit vaccine (PreS-RBD) based on a structurally folded recombinant fusion protein consisting of two SARS-CoV-2 Spike protein receptor-binding domains (RBD) fused to the N- and C-terminus of hepatitis B virus (HBV) surface antigen PreS to enable the two unrelated proteins serving as immunologic carriers for each other.\n\nPreS-RBD, but not RBD alone, induced a robust and uniform RBD-specific IgG response in rabbits. Currently available genetic SARS-CoV-2 vaccines induce mainly transient IgG1 responses in vaccinated subjects whereas the PreS-RBD vaccine induced RBD-specific IgG antibodies consisting of an early IgG1 and sustained IgG4 antibody response in a SARS-CoV-2 naive subject. PreS-RBD-specific IgG antibodies were detected in serum and mucosal secretions, reacted with SARS-CoV-2 variants, including the omicron variant of concern and the HBV receptor-binding sites on PreS of currently known HBV genotypes. PreS-RBD-specific antibodies of the immunized subject more potently inhibited the interaction of RBD with its human receptor ACE2 and their virus-neutralizing titers (VNTs) were higher than median VNTs in a random sample of healthy subjects fully immunized with registered SARS-CoV-2 vaccines or in COVID-19 convalescent subjects.\n\nThe PreS-RBD vaccine has the potential to serve as a combination vaccine for inducing sterilizing immunity against SARS-CoV-2 and HBV by stopping viral replication through the inhibition of cellular virus entry.", "doi": "10.1111/all.15305", "pmid": "35357709", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC9111473"}], "notes": [], "created": "2022-04-04T06:34:40.717Z", "modified": "2022-06-21T18:21:30.822Z"}, {"entity": "publication", "iuid": "6e24f7cb3e584302898f650734b1a74a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e24f7cb3e584302898f650734b1a74a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e24f7cb3e584302898f650734b1a74a"}}, "title": "Long-term outcomes of dexamethasone 12 mg versus 6 mg in patients with COVID-19 and severe hypoxaemia.", "authors": [{"family": "Granholm", "given": "Anders", "initials": "A"}, {"family": "Kj\u00e6r", "given": "Maj-Brit N\u00f8rregaard", "initials": "MN"}, {"family": "Munch", "given": "Marie Warrer", "initials": "MW"}, {"family": "Myatra", "given": "Sheila Nainan", "initials": "SN"}, {"family": "Vijayaraghavan", "given": "Bharath Kumar Tirupakuzhi", "initials": "BKT"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Wahlin", "given": "Rebecka Rubenson", "initials": "RR"}, {"family": "Jakob", "given": "Stephan M", "initials": "SM"}, {"family": "Cioccari", "given": "Luca", "initials": "L"}, {"family": "Vesterlund", "given": "Gitte Kingo", "initials": "GK"}, {"family": "Meyhoff", "given": "Tine Sylvest", "initials": "TS"}, {"family": "Helleberg", "given": "Marie", "initials": "M"}, {"family": "M\u00f8ller", "given": "Morten Hylander", "initials": "MH"}, {"family": "Benfield", "given": "Thomas", "initials": "T"}, {"family": "Venkatesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Hammond", "given": "Naomi E", "initials": "NE"}, {"family": "Micallef", "given": "Sharon", "initials": "S"}, {"family": "Bassi", "given": "Abhinav", "initials": "A"}, {"family": "John", "given": "Oommen", "initials": "O"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Kristiansen", "given": "Klaus Tjelle", "initials": "KT"}, {"family": "Ulrik", "given": "Charlotte Suppli", "initials": "CS"}, {"family": "J\u00f8rgensen", "given": "Vibeke Lind", "initials": "VL"}, {"family": "Smitt", "given": "Margit", "initials": "M"}, {"family": "Bestle", "given": "Morten H", "initials": "MH"}, {"family": "Andreasen", "given": "Anne Sofie", "initials": "AS"}, {"family": "Poulsen", "given": "Lone Musaeus", "initials": "LM"}, {"family": "Rasmussen", "given": "Bodil Steen", "initials": "BS"}, {"family": "Br\u00f8chner", "given": "Anne Craveiro", "initials": "AC"}, {"family": "Str\u00f8m", "given": "Thomas", "initials": "T"}, {"family": "M\u00f8ller", "given": "Anders", "initials": "A"}, {"family": "Khan", "given": "Mohd Saif", "initials": "MS"}, {"family": "Padmanaban", "given": "Ajay", "initials": "A"}, {"family": "Divatia", "given": "Jigeeshu Vasishtha", "initials": "JV"}, {"family": "Saseedharan", "given": "Sanjith", "initials": "S"}, {"family": "Borawake", "given": "Kapil", "initials": "K"}, {"family": "Kapadia", "given": "Farhad", "initials": "F"}, {"family": "Dixit", "given": "Subhal", "initials": "S"}, {"family": "Chawla", "given": "Rajesh", "initials": "R"}, {"family": "Shukla", "given": "Urvi", "initials": "U"}, {"family": "Amin", "given": "Pravin", "initials": "P"}, {"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Wamberg", "given": "Christian Aage", "initials": "CA"}, {"family": "Bose", "given": "Neeta", "initials": "N"}, {"family": "Shah", "given": "Mehul S", "initials": "MS"}, {"family": "Darfelt", "given": "Iben S", "initials": "IS"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Lange", "given": "Theis", "initials": "T"}, {"family": "Perner", "given": "Anders", "initials": "A", "orcid": "0000-0002-4668-0123", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5d5120bc69c433f9df2b929d6be905a.json"}}], "type": "journal article", "published": "2022-03-31", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "issn-l": "0342-4642"}, "abstract": "We assessed long-term outcomes of dexamethasone 12 mg versus 6 mg given daily for up to 10 days in patients with coronavirus disease 2019 (COVID-19) and severe hypoxaemia.\n\nWe assessed 180-day mortality and health-related quality of life (HRQoL) using EuroQoL (EQ)-5D-5L index values and EQ visual analogue scale (VAS) in the international, stratified, blinded COVID STEROID 2 trial, which randomised 1000 adults with confirmed COVID-19 receiving at least 10 L/min of oxygen or mechanical ventilation in 26 hospitals in Europe and India. In the HRQoL analyses, higher values indicated better outcomes, and deceased patients were given a score of zero.\n\nWe obtained vital status at 180 days for 963 of 982 patients (98.1%) in the intention-to-treat population, EQ-5D-5L index value data for 922 (93.9%) and EQ VAS data for 924 (94.1%). At 180 days, 164 of 486 patients (33.7%) had died in the 12 mg group versus 184 of 477 (38.6%) in the 6 mg group [adjusted risk difference - 4.3%; 99% confidence interval (CI) - 11.7-3.0; relative risk 0.89; 0.72-1.09; P = 0.13]. The adjusted mean differences between the 12 mg and the 6 mg groups in EQ-5D-5L index values were 0.06 (99% CI - 0.01 to 0.12; P = 0.10) and in EQ VAS scores 4 (- 3 to 10; P = 0.22).\n\nAmong patients with COVID-19 and severe hypoxaemia, dexamethasone 12 mg compared with 6 mg did not result in statistically significant improvements in mortality or HRQoL at 180 days, but the results were most compatible with benefit from the higher dose.", "doi": "10.1007/s00134-022-06677-2", "pmid": "35359168", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-022-06677-2"}, {"db": "pmc", "key": "PMC8970069"}, {"db": "ClinicalTrials.gov", "key": "NCT04509973"}], "notes": [], "created": "2022-04-04T06:33:48.635Z", "modified": "2022-04-04T06:34:05.700Z"}, {"entity": "publication", "iuid": "18980b26d5f84f00b2e0b6e40b94d549", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18980b26d5f84f00b2e0b6e40b94d549.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18980b26d5f84f00b2e0b6e40b94d549"}}, "title": "Impact of the COVID-19 pandemic on subcutaneous venous port-related complications in patients with cancer: a retrospective case-control study.", "authors": [{"family": "Dahlin", "given": "Linnea", "initials": "L", "orcid": "0000-0002-8888-6103", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8dd7b90b88c34a168048b508c6f883b1.json"}}, {"family": "Taxbro", "given": "Knut", "initials": "K"}, {"family": "Hammarskj\u00f6ld", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2022-03-31", "journal": {"title": "World J Surg Oncol", "issn": "1477-7819", "volume": "20", "issue": "1", "pages": "103", "issn-l": null}, "abstract": "Vascular access in cancer patients is of great importance in order to deliver tumour-specific therapy and continues to be so during exceptional conditions. This study aimed to examine the impact of the coronavirus disease 2019 pandemic on the care and complication rates associated with subcutaneous venous port (PORT) insertion in cancer treatment.\n\nWe retrospectively studied all adult cancer patients that received a PORT in 2020 at a Swedish county hospital, including insertion characteristics and in-dwell complication rates for up to 6 months after implantation; these estimates were compared with historic data.\n\nData from 257 patients, of which 56 were haematological patients, were included and compared with those of 168 patients in the control group. The group characteristics were similar, except for the inclusion of haematological patients in the study group. Insertion characteristics showed a shorter waiting time and higher rates of antibiotic and sedative use during the pandemic. The rates of postoperative haematoma and catheter occlusion during the study period were higher than otherwise. The rates of adverse events related to the PORT in the solid tumour group were comparable to those in the control group (18.4% vs. 14.9%). Patients with haematological malignancies were more likely to experience adverse events (37.5% vs. 18.4%) and deep venous thrombosis (7.1% vs. 1.0%) than those with solid tumours.\n\nIn conclusion, the present findings suggest that PORTs remain a safe venous access system even during a pandemic, indicating a robust vascular access service.", "doi": "10.1186/s12957-022-02568-4", "pmid": "35354461", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12957-022-02568-4"}, {"db": "pmc", "key": "PMC8967566"}], "notes": [], "created": "2022-04-04T06:35:00.532Z", "modified": "2022-04-04T06:35:10.622Z"}, {"entity": "publication", "iuid": "0b309d7eb77b4a2eb072680743bb7a12", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b309d7eb77b4a2eb072680743bb7a12.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b309d7eb77b4a2eb072680743bb7a12"}}, "title": "Validation of the Canadian French version of the fear of COVID-19 scale in the general population of Quebec.", "authors": [{"family": "Attieh", "given": "Randa", "initials": "R"}, {"family": "Koffi", "given": "Kouam\u00e9", "initials": "K"}, {"family": "Tour\u00e9", "given": "Moustapha", "initials": "M", "orcid": "0000-0002-7640-0356", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b5b37d4661e49d090af2f83a0061f8b.json"}}, {"family": "Parr-Labb\u00e9", "given": "\u00c9rica", "initials": "\u00c9"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}, {"family": "Poder", "given": "Thomas G", "initials": "TG"}], "type": "journal article", "published": "2022-03-30", "journal": {"title": "Brain Behav", "issn": "2162-3279", "pages": "e32550", "issn-l": null}, "abstract": "The purpose of this study was to develop a Canadian French translation of the fear of COVID-19 scale (FCV-19S) and assess its psychometric characteristics.\n\nA forward and backtranslation process was conducted for the Canadian French version of the FCV-19S. The guidance of the ISPOR task force for translation and cultural adaptation was followed and cognitive debriefing interviews were conducted with six citizens. The final proofread Canadian French FCV-19S was then administered to a large sample of citizens from the province of Quebec in Canada through an online survey. A quota sampling was conducted in 2020. Respondents from the survey also completed the Clinical Outcomes in Routine Evaluation (CORE)-6D and the Sense of Coherence (SOC-3) questionnaires. Several psychometric tests were performed to investigate the reliability (internal consistency) and validity of the Canadian French FCV-19S, including construct validity, concurrent validity, and Rasch analysis.\n\nThe translation process was conducted without any major difficulties. The cognitive debriefing interviews led to no change in the reconciled translation. The survey collected answers from 3428 citizens. Results indicated that the factor structure of the Canadian French FCV-19S is a unidimensional factor fitting well with the data. The scale showed adequate reliability (Cronbach's alpha of .903) and concurrent validity, as indicated by significantly negative correlation with CORE-6D (r = -.410) and SOC-3 (r = -.233). The Canadian French FCV-19S properties tested using Rasch analysis was also very satisfactory.\n\nThe results of the present study indicated that the Canadian French version of FCV-19S is a unidimensional tool with robust psychometric properties in the adult's population of all ages residing in the province of Quebec, Canada.", "doi": "10.1002/brb3.2550", "pmid": "35353955", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-04-04T06:35:37.045Z", "modified": "2022-04-04T06:35:37.121Z"}, {"entity": "publication", "iuid": "2cf3de26096e435d8fd40a28afe2228b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2cf3de26096e435d8fd40a28afe2228b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2cf3de26096e435d8fd40a28afe2228b"}}, "title": "We're on mute! Exclusion of nurses' voices in national decisions and responses to COVID-19: An international perspective.", "authors": [{"family": "Rasmussen", "given": "Bodil", "initials": "B", "orcid": "0000-0002-6789-8260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24463789a4fa42f88a120f098ce640e0.json"}}, {"family": "Holton", "given": "Sara", "initials": "S", "orcid": "0000-0001-9294-7872", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64829fda675a413fbb2b7fedb14f37a9.json"}}, {"family": "Wynter", "given": "Karen", "initials": "K", "orcid": "0000-0003-4620-7691", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a09500b4fc034472b2d89d898f9ac75e.json"}}, {"family": "Phillips", "given": "David J", "initials": "DJ"}, {"family": "David", "given": "Jennifer L", "initials": "JL", "orcid": "0000-0001-6297-6429", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/755ec5167d52464cba85ebeb62bf8dd2.json"}}, {"family": "Rothmann", "given": "Mette Juel", "initials": "MJ", "orcid": "0000-0001-6505-4163", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4fc0ce619c694a1fbd6cd042105bb3b9.json"}}, {"family": "Skjoeth", "given": "Mette Maria", "initials": "MM", "orcid": "0000-0002-3528-4619", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa8742bfe09d4ea2be9f287ff3af0d72.json"}}, {"family": "Wijk", "given": "Helle", "initials": "H", "orcid": "0000-0001-8799-6856", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d845c2268c748dba1348a56f2b82589.json"}}, {"family": "Frederiksen", "given": "Kirsten", "initials": "K", "orcid": "0000-0002-2082-7094", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/938fbb5dfb1b45329e124f17cedee58e.json"}}, {"family": "Ahlstrom", "given": "Linda", "initials": "L", "orcid": "0000-0002-3372-8722", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f026139e64a84dfe9de9cd89aca4f6f7.json"}}, {"family": "Anderson", "given": "Janet E", "initials": "JE", "orcid": "0000-0002-1452-8370", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7fde0f4a4b24d6c8e1d934b30915757.json"}}, {"family": "Harris", "given": "Ruth", "initials": "R", "orcid": "0000-0002-4377-5063", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/635193f5f85f4f62b922411377749704.json"}}, {"family": "Conolly", "given": "Anna", "initials": "A", "orcid": "0000-0002-0747-4597", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4573b079b6cc450dbe271a6bcce1ebf9.json"}}, {"family": "Kent", "given": "Bridie", "initials": "B", "orcid": "0000-0001-9550-1913", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef4f521d21324590bfe3618a30a885c8.json"}}, {"family": "Maben", "given": "Jill", "initials": "J", "orcid": "0000-0002-6168-0455", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a3518673bd24747844fff98628584e0.json"}}], "type": "editorial", "published": "2022-03-29", "journal": {"title": "J Adv Nurs", "issn": "1365-2648", "issn-l": null}, "abstract": null, "doi": "10.1111/jan.15236", "pmid": "35352392", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9111388"}], "notes": [], "created": "2022-04-04T06:36:00.777Z", "modified": "2022-06-21T18:21:06.170Z"}, {"entity": "publication", "iuid": "eb0a8f3e367944d58d8598c523376c6f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb0a8f3e367944d58d8598c523376c6f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb0a8f3e367944d58d8598c523376c6f"}}, "title": "Impacts of changes in environmental exposures and health behaviours due to the COVID-19 pandemic on cardiovascular and mental health: A comparison of Barcelona, Vienna, and Stockholm.", "authors": [{"family": "Koch", "given": "Sarah", "initials": "S"}, {"family": "Khomenko", "given": "Sasha", "initials": "S"}, {"family": "Cirach", "given": "Marta", "initials": "M"}, {"family": "Ubalde-Lopez", "given": "M\u00f2nica", "initials": "M"}, {"family": "Baclet", "given": "Sacha", "initials": "S"}, {"family": "Daher", "given": "Carolyn", "initials": "C"}, {"family": "Hidalgo", "given": "Laura", "initials": "L"}, {"family": "L\u00f5hmus", "given": "Mare", "initials": "M"}, {"family": "Rizzuto", "given": "Debora", "initials": "D"}, {"family": "Rumpler", "given": "Romain", "initials": "R"}, {"family": "Susilo", "given": "Yusak", "initials": "Y"}, {"family": "Venkataraman", "given": "Siddharth", "initials": "S"}, {"family": "Wegener", "given": "Sandra", "initials": "S"}, {"family": "Wellenius", "given": "Gregory A", "initials": "GA"}, {"family": "Woodcock", "given": "James", "initials": "J"}, {"family": "Nieuwenhuijsen", "given": "Mark", "initials": "M"}], "type": "journal article", "published": "2022-03-29", "journal": {"title": "Environ Pollut", "issn": "1873-6424", "pages": "119124", "issn-l": null}, "abstract": "Responses to COVID-19 altered environmental exposures and health behaviours associated with non-communicable diseases. We aimed to (1) quantify changes in nitrogen dioxide (NO2), noise, physical activity, and greenspace visits associated with COVID-19 policies in the spring of 2020 in Barcelona (Spain), Vienna (Austria), and Stockholm (Sweden), and (2) estimated the number of additional and prevented diagnoses of myocardial infarction (MI), stroke, depression, and anxiety based on these changes. We calculated differences in NO2, noise, physical activity, and greenspace visits between pre-pandemic (baseline) and pandemic (counterfactual) levels. With two counterfactual scenarios, we distinguished between Acute Period (March 15th - April 26th, 2020) and Deconfinement Period (May 2nd - June 30th, 2020) assuming counterfactual scenarios were extended for 12 months. Relative risks for each exposure difference were estimated with exposure-risk functions. In the Acute Period, reductions in NO2 (range of change from -16.9 \u03bcg/m3 to -1.1 \u03bcg/m3), noise (from -5 dB(A) to -2 dB(A)), physical activity (from -659 MET*min/wk to -183 MET*min/wk) and greenspace visits (from -20.2 h/m to 1.1 h/m) were largest in Barcelona and smallest in Stockholm. In the Deconfinement Period, NO2 (from -13.9 \u03bcg/m3 to -3.1 \u03bcg/m3), noise (from -3 dB(A) to -1 dB(A)), and physical activity levels (from -524 MET*min/wk to -83 MET*min/wk) remained below pre-pandemic levels in all cities. Greatest impacts were caused by physical activity reductions. If physical activity levels in Barcelona remained at Acute Period levels, increases in annual diagnoses for MI (mean: 572 (95% CI: 224, 943)), stroke (585 (6, 1156)), depression (7903 (5202, 10,936)), and anxiety (16,677 (926, 27,002)) would be anticipated. To decrease cardiovascular and mental health impacts, reductions in NO2 and noise from the first COVID-19 surge should be sustained, but without reducing physical activity. Focusing on cities' connectivity that promotes active transportation and reduces motor vehicle use assists in achieving this goal.", "doi": "10.1016/j.envpol.2022.119124", "pmid": "35367103", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0269-7491(22)00338-4"}], "notes": [], "created": "2022-04-04T06:21:29.659Z", "modified": "2022-04-04T06:21:29.689Z"}, {"entity": "publication", "iuid": "60101c2caae04a6f89bc2b6dbcaed531", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60101c2caae04a6f89bc2b6dbcaed531.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60101c2caae04a6f89bc2b6dbcaed531"}}, "title": "Self-reported mental health status of pregnant women in Sweden during the COVID-19 pandemic: a cross-sectional survey.", "authors": [{"family": "Ho-Fung", "given": "Chung", "initials": "C"}, {"family": "Andersson", "given": "Ewa", "initials": "E"}, {"family": "Hsuan-Ying", "given": "Huang", "initials": "H"}, {"family": "Acharya", "given": "Ganesh", "initials": "G", "orcid": "0000-0002-1997-3107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d1c2ac0dfb849d8b2374451e38cdcba.json"}}, {"family": "Schwank", "given": "Simone", "initials": "S"}], "type": "journal article", "published": "2022-03-28", "journal": {"title": "BMC Pregnancy Childbirth", "issn": "1471-2393", "volume": "22", "issue": "1", "pages": "260", "issn-l": null}, "abstract": "The COVID-19 pandemic has contributed to unprecedented worries and challenges for pregnant women due to social restrictions and changes in maternity care provision. We aimed to investigate the mental health impact of COVID-19 pandemic on pregnant women in Sweden and explore factors associated with poor perinatal mental health in this specific context.\n\nThis was a nation-wide cross-sectional survey of pregnant women living in Sweden. Validated questionnaires were distributed through non-profit organizations\u00b4 websites and social media channels from May 2020 to February 2021. Perinatal depression, anxiety, and acute stress reaction were assessed using the Edinburgh Postnatal Depression Scale (EPDS), Generalized Anxiety Disorder-7 (GAD-7) and Impact Event Scale (Revised) (IES-R), respectively. Sociodemographic characteristics and self-perceived mental well-being were also obtained. Factors associated with mental health outcomes were analyzed using multivariate logistic regression model.\n\nAmong a total of 470 participants, 43.2% (n = 203) reported depression (EPDS \u226513), 25.7% (n = 121) moderate to severe anxiety (GAD-7 score \u2265 10), and 23.7% (n = 110) moderate to severe acute stress reaction (IES-R \u2265 33). 27.4% participants (n = 129) expressed concerns regarding their mental well-being during the pandemic. Pregnant mothers who had sick family members reported poorer mental health outcomes than those who did not (median [Interquartile range (IQR)] EPDS scores: 14.0 [8.75-18.0] vs 11.0 [6.25-15.0], p < .001; median (IQR) GAD7 scores: 7.0 [4.0-12.25] vs 6.0 [3.0-9.0], p = .003); median (IQR) IES-R scores: 20.0 [9.0-38.0] vs 15.0 [7.0-30.0], p = .048). Logistic regression analyses revealed that risk factors for poor mental health outcomes were having a sick family member with any illness, unemployment, and experiencing a substantially stressful life event. Having a higher educational level and a younger age during the pandemic were protective.\n\nDepression and anxiety were highly prevalent among pregnant women in Sweden during the COVID-19 pandemic, indicating a need for professional mental health support for this vulnerable group of population. Unemployment was an associated risk factor whereas younger age and higher educational level were protective suggesting an important role of socio-economic factors in modulating the impact of COVID-19 pandemic on perinatal mental health.", "doi": "10.1186/s12884-022-04553-x", "pmid": "35351030", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12884-022-04553-x"}, {"db": "pmc", "key": "PMC8960205"}], "notes": [], "created": "2022-04-04T06:36:23.404Z", "modified": "2022-04-04T06:36:23.439Z"}, {"entity": "publication", "iuid": "c2a1cee2d065457ba3ed30b21ec49f01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2a1cee2d065457ba3ed30b21ec49f01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2a1cee2d065457ba3ed30b21ec49f01"}}, "title": "The Karolinska NeuroCOVID study protocol: Neurocognitive impairment, biomarkers and advanced imaging in critical care survivors.", "authors": [{"family": "Nelson", "given": "David W", "initials": "DW"}, {"family": "Granberg", "given": "Tobias", "initials": "T"}, {"family": "Andersen", "given": "Pia", "initials": "P"}, {"family": "Jokhadar", "given": "Elias", "initials": "E"}, {"family": "K\u00e5hlin", "given": "Jessica", "initials": "J"}, {"family": "Granstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Hallinder", "given": "Helena", "initials": "H"}, {"family": "Schening", "given": "Anna", "initials": "A"}, {"family": "Thunborg", "given": "Charlotta", "initials": "C"}, {"family": "Walles", "given": "H\u00e5kan", "initials": "H"}, {"family": "Hagman", "given": "G\u00f6ran", "initials": "G"}, {"family": "Shams-Latifi", "given": "Roya", "initials": "R"}, {"family": "Yu", "given": "Jimmy", "initials": "J"}, {"family": "Petersson", "given": "Sven", "initials": "S"}, {"family": "Tzortzakakis", "given": "Antonios", "initials": "A"}, {"family": "Levak", "given": "Nicholas", "initials": "N"}, {"family": "Asp\u00f6", "given": "Malin", "initials": "M"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}], "type": "journal article", "published": "2022-03-25", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172"}, "abstract": "This is the study plan of the Karolinska NeuroCOVID study, a study of neurocognitive impairment after severe COVID-19, relating post-intensive care unit (ICU) cognitive and neurological deficits to biofluid markers and MRI. The COVID-19 pandemic has posed enormous health challenges to individuals and health-care systems worldwide. An emerging feature of severe COVID-19 is that of temporary and extended neurocognitive impairment, exhibiting a myriad of symptoms and signs. The causes of this symptomatology have not yet been fully elucidated.\n\nIn this study, we aim to investigate patients treated for severe COVID-19 in the ICU, as to describe and relate serum-, plasma- and cerebrospinal fluid-borne molecular and cellular biomarkers of immune activity, coagulopathy, cerebral damage, neuronal inflammation, and degeneration, to the temporal development of structural and functional changes within the brain as evident by serial MRI and extensive cognitive assessments at 3-12 months after ICU discharge.\n\nTo date, we have performed 51 3-month follow-up MRIs in the ICU survivors. Of these, two patients (~4%) have had incidental findings on brain MRI findings requiring activation of the Incidental Findings Management Plan. Furthermore, the neuropsychological and neurological examinations have so far revealed varying and mixed patterns. Several patients expressed cognitive and/or mental concerns and fatigue, complaints closely related to brain fog.\n\nThe study goal is to gain a better understanding of the pathological mechanisms and neurological consequences of this new disease, with a special emphasis on neurodegenerative and neuroinflammatory processes, in order to identify targets of intervention and rehabilitation.", "doi": "10.1111/aas.14062", "pmid": "35332517", "labels": {"Category: Health": null, "Funder: VR": null, "Category: Biochemistry": null, "Funder: Forte": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-04-04T06:58:30.523Z", "modified": "2022-04-04T06:58:30.537Z"}, {"entity": "publication", "iuid": "3e554caa8e4348698c04b63cadcfdf08", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3e554caa8e4348698c04b63cadcfdf08.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3e554caa8e4348698c04b63cadcfdf08"}}, "title": "Outcomes of SARS-CoV-2 infection among children and young people with pre-existing rheumatic and musculoskeletal diseases.", "authors": [{"family": "Kearsley-Fleet", "given": "Lianne", "initials": "L", "orcid": "0000-0003-0377-1575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9cc64aac266462baf67998b3d49c6f7.json"}}, {"family": "Chang", "given": "Min-Lee", "initials": "ML", "orcid": "0000-0001-9868-4030", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b28b0d9449d40d4a5eb1580a78f02b7.json"}}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S", "orcid": "0000-0002-8611-162X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73b17eb08d984421847f733b7a6a49d4.json"}}, {"family": "Costello", "given": "Ruth", "initials": "R", "orcid": "0000-0003-2709-6666", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c0fe69f61b54ab89f9a3de852f872a8.json"}}, {"family": "Fingerhutov\u00e1", "given": "\u0160\u00e1rka", "initials": "\u0160", "orcid": "0000-0003-2170-2688", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a96659bf4264bf799ef50ecae0c8b37.json"}}, {"family": "\u0160vestkov\u00e1", "given": "Nat\u00e1lie", "initials": "N"}, {"family": "Belot", "given": "Alexandre", "initials": "A", "orcid": "0000-0003-4902-5332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbf2b4fa1aa14e359603cfc5fdf38439.json"}}, {"family": "Aeschlimann", "given": "Florence A", "initials": "FA", "orcid": "0000-0001-7212-9151", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fd044aff5324e22a42e0d90d2edbfea.json"}}, {"family": "Melki", "given": "Isabelle", "initials": "I", "orcid": "0000-0002-8057-333X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48f0d34d38644394a0707b1bd62d3c0e.json"}}, {"family": "Kon\u00e9-Paut", "given": "Isabelle", "initials": "I", "orcid": "0000-0001-8939-5763", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18d5124274b34a10a72a755258035099.json"}}, {"family": "Eulert", "given": "Sascha", "initials": "S", "orcid": "0000-0002-7921-708X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37cbd77e83b04c82a9b6343afcdc5c83.json"}}, {"family": "Kallinich", "given": "Tilmann", "initials": "T", "orcid": "0000-0003-2404-9397", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b028eb778594e95ade00b6e18fc6bc6.json"}}, {"family": "Berkun", "given": "Yackov", "initials": "Y", "orcid": "0000-0001-9823-4750", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32ae7278290547c58db4994ff2b9c621.json"}}, {"family": "Uziel", "given": "Yosef", "initials": "Y", "orcid": "0000-0003-4655-1652", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d555727f6aa482891e28b936a5b4419.json"}}, {"family": "Raffeiner", "given": "Bernd", "initials": "B", "orcid": "0000-0002-7719-1736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9593bcad2ce747e3a65e7160559e3f5e.json"}}, {"family": "Oliveira Ramos", "given": "Filipa", "initials": "F"}, {"family": "Clemente", "given": "Daniel", "initials": "D", "orcid": "0000-0002-1605-7488", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6527b4ae3e38472cafc253c6e0155dda.json"}}, {"family": "Dackhammar", "given": "Christina", "initials": "C", "orcid": "0000-0001-9389-4282", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd9333db812c40389d8f20149efb4f2b.json"}}, {"family": "Wulffraat", "given": "Nico M", "initials": "NM", "orcid": "0000-0001-9548-5562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a14b62a27efe4966980036c8366d557c.json"}}, {"family": "Waite", "given": "Helen", "initials": "H", "orcid": "0000-0002-8435-9496", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d33974aecf224f8a89df175a5f487c56.json"}}, {"family": "Strangfeld", "given": "Anja", "initials": "A", "orcid": "0000-0002-6233-022X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/644005e83dff44b7bdca5d2b818e17d5.json"}}, {"family": "Mateus", "given": "Elsa F", "initials": "EF", "orcid": "0000-0003-0059-2141", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cbb817ab9e6e448db217bab218522259.json"}}, {"family": "Machado", "given": "Pedro M", "initials": "PM", "orcid": "0000-0002-8411-7972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef40d1eea57946e4a37d2e92a02a47cd.json"}}, {"family": "CARRA Registry Investigators", "given": "", "initials": ""}, {"family": "COVID-19 Global Pediatric Rheumatology Database Investigators", "given": "", "initials": ""}, {"family": "Natter", "given": "Marc", "initials": "M", "orcid": "0000-0003-0748-2674", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8ebb638b08546b99ae50524ac3a41d5.json"}}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL", "orcid": "0000-0001-8242-9262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9ad49b088eb467ba6d1ca1559b88047.json"}}], "type": "journal article", "published": "2022-03-25", "journal": {"title": "Ann Rheum Dis", "issn": "1468-2060", "issn-l": null}, "abstract": "Some adults with rheumatic and musculoskeletal diseases (RMDs) are at increased risk of COVID-19-related death. Excluding post-COVID-19 multisystem inflammatory syndrome of children, children and young people (CYP) are overall less prone to severe COVID-19 and most experience a mild or asymptomatic course. However, it is unknown if CYP with RMDs are more likely to have more severe COVID-19. This analysis aims to describe outcomes among CYP with underlying RMDs with COVID-19.\n\nUsing the European Alliance of Associations for Rheumatology COVID-19 Registry, the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry, and the CARRA-sponsored COVID-19 Global Paediatric Rheumatology Database, we obtained data on CYP with RMDs who reported SARS-CoV-2 infection (presumptive or confirmed). Patient characteristics and illness severity were described, and factors associated with COVID-19 hospitalisation were investigated.\n\n607 CYP with RMDs <19 years old from 25 different countries with SARS-CoV-2 infection were included, the majority with juvenile idiopathic arthritis (JIA; n=378; 62%). Forty-three (7%) patients were hospitalised; three of these patients died. Compared with JIA, diagnosis of systemic lupus erythematosus, mixed connective tissue disease, vasculitis, or other RMD (OR 4.3; 95% CI 1.7 to 11) or autoinflammatory syndrome (OR 3.0; 95% CI 1.1 to 8.6) was associated with hospitalisation, as was obesity (OR 4.0; 95% CI 1.3 to 12).\n\nThis is the most significant investigation to date of COVID-19 in CYP with RMDs. It is important to note that the majority of CYP were not hospitalised, although those with severe systemic RMDs and obesity were more likely to be hospitalised.", "doi": "10.1136/annrheumdis-2022-222241", "pmid": "35338032", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "annrheumdis-2022-222241"}], "notes": [], "created": "2022-04-04T06:50:58.842Z", "modified": "2022-04-04T06:50:59.513Z"}, {"entity": "publication", "iuid": "ffd97f47a3b54f89af1ad45af6c5ff39", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ffd97f47a3b54f89af1ad45af6c5ff39.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ffd97f47a3b54f89af1ad45af6c5ff39"}}, "title": "Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies.", "authors": [{"family": "Hanke", "given": "Leo", "initials": "L", "orcid": "0000-0001-5514-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a35f10de4f2e4aee98278f6ab845613d.json"}}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ", "orcid": "0000-0002-0227-5636", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a612a313d5874131ba64d9811a5d4a08.json"}}, {"family": "Pankow", "given": "Alec", "initials": "A", "orcid": "0000-0001-9108-1683", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a88776116034bc79c08de50a18ad39d.json"}}, {"family": "Vidakovics", "given": "Laura Perez", "initials": "LP", "orcid": "0000-0003-4283-812X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b85cf54481e94b8c95f2bf8db1038395.json"}}, {"family": "Karl", "given": "Vivien", "initials": "V", "orcid": "0000-0001-7026-7622", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d823bd5715bd46c187e252626c726e5c.json"}}, {"family": "Kim", "given": "Changil", "initials": "C", "orcid": "0000-0003-4977-4384", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d36347170c34ca386deee72faccc534.json"}}, {"family": "Urgard", "given": "Egon", "initials": "E"}, {"family": "Smith", "given": "Natalie L", "initials": "NL"}, {"family": "Astorga-Wells", "given": "Juan", "initials": "J", "orcid": "0000-0003-1017-8841", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb77d4b2e89b4662ad360a51d0061ebf.json"}}, {"family": "Ekstr\u00f6m", "given": "Simon", "initials": "S"}, {"family": "Coquet", "given": "Jonathan M", "initials": "JM", "orcid": "0000-0002-5967-4857", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ca3e4664dc444a3a992531ad3dd9201.json"}}, {"family": "McInerney", "given": "Gerald M", "initials": "GM", "orcid": "0000-0003-2257-7241", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7770437d845444a8a07865bf5b62fab0.json"}}, {"family": "Murrell", "given": "Ben", "initials": "B", "orcid": "0000-0002-0393-4445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60dac9ecf84d4eb3b90fb4ee1298bc52.json"}}], "type": "journal article", "published": "2022-03-25", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "8", "issue": "12", "pages": "eabm0220", "issn-l": "2375-2548"}, "abstract": "Conventional approaches to isolate and characterize nanobodies are laborious. We combine phage display, multivariate enrichment, next-generation sequencing, and a streamlined screening strategy to identify numerous anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nanobodies. We characterize their potency and specificity using neutralization assays and hydrogen/deuterium exchange mass spectrometry (HDX-MS). The most potent nanobodies bind to the receptor binding motif of the receptor binding domain (RBD), and we identify two exceptionally potent members of this category (with monomeric half-maximal inhibitory concentrations around 13 and 16 ng/ml). Other nanobodies bind to a more conserved epitope on the side of the RBD and are able to potently neutralize the SARS-CoV-2 founder virus (42 ng/ml), the Beta variant (B.1.351/501Y.V2) (35 ng/ml), and also cross-neutralize the more distantly related SARS-CoV-1 (0.46 \u03bcg/ml). The approach presented here is well suited for the screening of phage libraries to identify functional nanobodies for various biomedical and biochemical applications.", "doi": "10.1126/sciadv.abm0220", "pmid": "35333580", "labels": {"Category: Health": null, "Funder: VR": null, "Category: Biochemistry": null, "Type: Journal article": null, "Funder: H2020": null}, "xrefs": [], "notes": [], "created": "2022-04-04T06:57:31.249Z", "modified": "2022-04-04T06:57:31.448Z"}, {"entity": "publication", "iuid": "d547d3166d794c54b9fcc8d4e39b1fd6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d547d3166d794c54b9fcc8d4e39b1fd6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d547d3166d794c54b9fcc8d4e39b1fd6"}}, "title": "Author Correction: Self-reported COVID-19 vaccine hesitancy and uptake among participants from different racial and ethnic groups in the United States and United Kingdom.", "authors": [{"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Merino", "given": "Jordi", "initials": "J", "orcid": "0000-0001-8312-1438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12ab049914a542b39affcfb4196861d2.json"}}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Lo", "given": "Chun-Han", "initials": "CH", "orcid": "0000-0001-8202-4513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a0d9111318f4084b64f47b5b56c8c85.json"}}, {"family": "Kwon", "given": "Sohee", "initials": "S", "orcid": "0000-0002-4201-9522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/850aeda246cd44e88071b97d54b358b5.json"}}, {"family": "Wang", "given": "Kai", "initials": "K"}, {"family": "Graham", "given": "Mark S", "initials": "MS"}, {"family": "Polidori", "given": "Lorenzo", "initials": "L"}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874802ae65824a90ba50eabdeabb8356.json"}}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Anyane-Yeboa", "given": "Adjoa", "initials": "A"}, {"family": "Astley", "given": "Christina M", "initials": "CM", "orcid": "0000-0002-5063-8470", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98ce30ec7a7d45389d75aba2defce392.json"}}, {"family": "Warner", "given": "Erica T", "initials": "ET"}, {"family": "Hu", "given": "Christina Y", "initials": "CY"}, {"family": "Selvachandran", "given": "Somesh", "initials": "S"}, {"family": "Davies", "given": "Richard", "initials": "R", "orcid": "0000-0003-2050-3994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b82cc92615f462d9af0153a6fb94fde.json"}}, {"family": "Nash", "given": "Denis", "initials": "D"}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74cf1f7094744ee289fa5df041e7cb5b.json"}}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-7284-6767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeefbf47fd384d5390109fe1a903bd18.json"}}, {"family": "COPE Consortium", "given": "", "initials": ""}], "type": "published erratum", "published": "2022-03-25", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "1715", "issn-l": "2041-1723"}, "abstract": null, "doi": "10.1038/s41467-022-29100-2", "pmid": "35338133", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-022-29100-2"}, {"db": "pmc", "key": "PMC8956141"}], "notes": [], "created": "2022-04-04T06:50:41.013Z", "modified": "2022-04-04T06:50:41.134Z"}, {"entity": "publication", "iuid": "5e72d64a6f384c0aa69b85d97a5735f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e72d64a6f384c0aa69b85d97a5735f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e72d64a6f384c0aa69b85d97a5735f0"}}, "title": "A population-based cohort approach to assess excess mortality due to the spread of COVID-19 in Italy, January-May 2020.", "authors": [{"family": "Dorrucci", "given": "Maria", "initials": "M"}, {"family": "Minelli", "given": "Giada", "initials": "G"}, {"family": "Boros", "given": "Stefano", "initials": "S"}, {"family": "Manno", "given": "Valerio", "initials": "V"}, {"family": "Prati", "given": "Sabrina", "initials": "S"}, {"family": "Battaglini", "given": "Marco", "initials": "M"}, {"family": "Corsetti", "given": "Gianni", "initials": "G"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Vescio", "given": "Maria Fenicia", "initials": "MF"}, {"family": "Spuri", "given": "Matteo", "initials": "M"}, {"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Italian Integrated Surveillance COVID-19 Group", "given": "", "initials": ""}, {"family": "Italian Integrated Surveillance COVID-19 group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-03-25", "journal": {"title": "Ann Ist Super Sanita", "issn": "2384-8553", "volume": "58", "issue": "1", "pages": "25-33", "issn-l": null}, "abstract": "To assess the impact of the COVID-19 pandemic on all-cause mortality in Italy during the first wave of the epidemic, taking into consideration the geographical heterogeneity of the spread of COVID-19.\n\nThis study is a retrospective, population-based cohort study using national statistics throughout Italy. Survival analysis was applied to data aggregated by day of death, age groups, sex, and Italian administrative units (107 provinces). We applied Cox models to estimate the relative hazards (RH) of excess mortality, comparing all-cause deaths in 2020 with the expected deaths from all causes in the same time period. The RH of excess deaths was estimated in areas with a high, moderate, and low spread of COVID-19. We reported the estimate also restricting the analysis to the period of March-April 2020 (first peak of the epidemic).\n\nThe study population consisted of 57,204,501 individuals living in Italy as of January 1, 2020. The number of excess deaths was 36,445, which accounts for 13.4% of excess mortalities from all causes during January-May 2020 (i.e., RH = 1.134; 95% confidence interval (CI): 1.129-1.140). In the macro-area with a relatively higher spread of COVID-19 (i.e., incidence rate, IR): 450-1,610 cases per 100,000 residents), the RH of excess deaths was 1.375 (95% CI: 1.364-1.386). In the area with a relatively moderate spread of COVID-19 (i.e., IR: 150-449 cases) it was 1.049 (95% CI: 1.038-1.060). In the area with a relatively lower spread of COVID-19 (i.e., IR: 30-149 cases), it was 0.967 (95% CI: 0.959-0.976). Between March and April (peak months of the first wave of the epidemic in Italy), we estimated an excess mortality from all causes of 43.5%. The RH of all-cause mortality for increments of 500 cases per 100,000 residents was 1.352 (95% CI: 1.346-1.359), corresponding to an increase of about 35%.\n\nOur analysis, making use of a population-based cohort model, estimated all-cause excess mortality in Italy taking account of both time period and of COVID-19 geographical spread. The study highlights the importance of a temporal/geographic framework in analyzing the risk of COVID-19-epidemy related mortality.", "doi": "10.4415/ANN_22_01_04", "pmid": "35324471", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Public Health": null, "Topics: Register-based research": null}, "xrefs": [], "notes": [], "created": "2022-04-04T07:00:43.085Z", "modified": "2022-04-04T07:00:52.509Z"}, {"entity": "publication", "iuid": "320c5e17ea1c4b2b94be7e555e8da3cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/320c5e17ea1c4b2b94be7e555e8da3cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/320c5e17ea1c4b2b94be7e555e8da3cb"}}, "title": "Selection analysis identifies clusters of unusual mutational changes in Omicron lineage BA.1 that likely impact Spike function.", "authors": [{"family": "Martin", "given": "Darren P", "initials": "DP", "orcid": "0000-0002-8785-0870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b43d72fdd57b4f908104e6f3056802ea.json"}}, {"family": "Lytras", "given": "Spyros", "initials": "S", "orcid": "0000-0003-4202-6682", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f440b2fe14e341bd829279d08a4a1de8.json"}}, {"family": "Lucaci", "given": "Alexander G", "initials": "AG"}, {"family": "Maier", "given": "Wolfgang", "initials": "W"}, {"family": "Gr\u00fcning", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Shank", "given": "Stephen D", "initials": "SD"}, {"family": "Weaver", "given": "Steven", "initials": "S"}, {"family": "MacLean", "given": "Oscar A", "initials": "OA", "orcid": "0000-0003-4919-4697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7169fd6ed48a4d10a0851eb90d2fb601.json"}}, {"family": "Orton", "given": "Richard J", "initials": "RJ", "orcid": "0000-0002-3389-4325", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7dae63399f52461ab68cefc6e6bc95d6.json"}}, {"family": "Lemey", "given": "Philippe", "initials": "P"}, {"family": "Boni", "given": "Maciej F", "initials": "MF"}, {"family": "Tegally", "given": "Houriiyah", "initials": "H"}, {"family": "Harkins", "given": "Gordon W", "initials": "GW"}, {"family": "Scheepers", "given": "Cathrine", "initials": "C"}, {"family": "Bhiman", "given": "Jinal N", "initials": "JN"}, {"family": "Everatt", "given": "Josie", "initials": "J"}, {"family": "Amoako", "given": "Daniel G", "initials": "DG"}, {"family": "San", "given": "James Emmanuel", "initials": "JE"}, {"family": "Giandhari", "given": "Jennifer", "initials": "J"}, {"family": "Sigal", "given": "Alex", "initials": "A", "orcid": "0000-0001-8571-2004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/197afb3112db40bd8d11247fa817b44f.json"}}, {"family": "NGS-SA", "given": "", "initials": ""}, {"family": "Williamson", "given": "Carolyn", "initials": "C"}, {"family": "Hsiao", "given": "Nei-Yuan", "initials": "NY"}, {"family": "von Gottberg", "given": "Anne", "initials": "A"}, {"family": "De Klerk", "given": "Arne", "initials": "A"}, {"family": "Shafer", "given": "Robert W", "initials": "RW"}, {"family": "Robertson", "given": "David L", "initials": "DL", "orcid": "0000-0001-6338-0221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7032efbe870440ccba1ebeed797be7b1.json"}}, {"family": "Wilkinson", "given": "Robert J", "initials": "RJ"}, {"family": "Sewell", "given": "B Trevor", "initials": "BT"}, {"family": "Lessells", "given": "Richard", "initials": "R"}, {"family": "Nekrutenko", "given": "Anton", "initials": "A", "orcid": "0000-0002-5987-8032", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e604351c6b64d15926f3392cd87ab87.json"}}, {"family": "Greaney", "given": "Allison J", "initials": "AJ"}, {"family": "Starr", "given": "Tyler N", "initials": "TN"}, {"family": "Bloom", "given": "Jesse D", "initials": "JD", "orcid": "0000-0003-1267-3408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f86f4a7b94e41358a4770ac2aa9b1b4.json"}}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Wilkinson", "given": "Eduan", "initials": "E"}, {"family": "Gupta", "given": "Ravindra K", "initials": "RK", "orcid": "0000-0001-9751-1808", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5fe96ec97d14f06a421cd22417544c9.json"}}, {"family": "de Oliveira", "given": "Tulio", "initials": "T", "orcid": "0000-0002-3027-5254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3dadcb78141a496ba76769d69667bf79.json"}}, {"family": "Kosakovsky Pond", "given": "Sergei L", "initials": "SL", "orcid": "0000-0003-4817-4029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59b8eb4236b3414291e4a0a5f81d5746.json"}}], "type": "journal article", "published": "2022-03-24", "journal": {"title": "Mol Biol Evol", "issn": "1537-1719", "issn-l": null}, "abstract": "Among the 30 non-synonymous nucleotide substitutions in the Omicron S-gene are 13 that have only rarely been seen in other SARS-CoV-2 sequences. These mutations cluster within three functionally important regions of the S-gene at sites that will likely impact (i) interactions between subunits of the Spike trimer and the predisposition of subunits to shift from down to up configurations, (ii) interactions of Spike with ACE2 receptors, and (iii) the priming of Spike for membrane fusion. We show here that, based on both the rarity of these 13 mutations in intrapatient sequencing reads and patterns of selection at the codon sites where the mutations occur in SARS-CoV-2 and related sarbecoviruses, prior to the emergence of Omicron the mutations would have been predicted to decrease the fitness of any virus within which they occurred. We further propose that the mutations in each of the three clusters therefore cooperatively interact to both mitigate their individual fitness costs, and, in combination with other mutations, adaptively alter the function of Spike. Given the evident epidemic growth advantages of Omicron over all previously known SARS-CoV-2 lineages, it is crucial to determine both how such complex and highly adaptive mutation constellations were assembled within the Omicron S-gene, and why, despite unprecedented global genomic surveillance efforts, the early stages of this assembly process went completely undetected.", "doi": "10.1093/molbev/msac061", "pmid": "35325204", "labels": {"Category: Health": null, "Category: Omicron VoC": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6553617"}], "notes": [], "created": "2022-04-04T07:00:24.978Z", "modified": "2022-04-04T07:00:25.380Z"}, {"entity": "publication", "iuid": "c9e79fd52e204fd7879a3be9141be7f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9e79fd52e204fd7879a3be9141be7f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9e79fd52e204fd7879a3be9141be7f7"}}, "title": "Role of Newly Introduced Teledentistry Service in the Management of Dental Emergencies During COVID-19 Pandemic in Qatar: A Cross-Sectional Analysis.", "authors": [{"family": "Ali", "given": "Shaymaa Abdulreda", "initials": "SA", "orcid": "0000-0003-3420-7096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5288ffb0fc4845fd82d93e3858762284.json"}}, {"family": "Al-Qahtani", "given": "Abdul Mueen A", "initials": "AMA"}, {"family": "Al Banai", "given": "Suhayla R", "initials": "SR"}, {"family": "Albaker", "given": "Fatima J", "initials": "FJ"}, {"family": "Almarri", "given": "Alanoud E", "initials": "AE"}, {"family": "Al-Haithami", "given": "Khalid", "initials": "K"}, {"family": "Khandakji", "given": "Mohannad N", "initials": "MN"}, {"family": "El Ansari", "given": "Walid", "initials": "W"}], "type": "journal article", "published": "2022-03-24", "journal": {"title": "Telemed J E Health", "issn": "1556-3669", "issn-l": null}, "abstract": "Introduction:The lockdown imposed by the COVID-19 pandemic rendered teledentistry (TD) necessary to maintain the continuity of oral health services and avoid missing emergency dental conditions, while minimizing face-to-face visits. Our objective was to evaluate the ability of a newly introduced triage-based TD service to deliver its goals, by evaluating its processes and outcomes and assessing the demand for TD. Methods:This cross-sectional report assessed the triage processes and outcomes (triage category, referral to emergency/dental facility undertaken, remote medications prescribed, and procedures performed at the point of referral); and evaluated the demand for the newly introduced TD service during 5 months of the first wave of the pandemic. Results:Of 850 calls, about 70.6% of the samples were managed remotely; 29.4% were categorized as emergency/urgent and referred to the emergency/dental facility. Compared with other complaints, orofacial dental pain was the most common reason for the calls (41.6%, p < 0.0001). About 14.71% of callers received prescription for medications remotely. The most demanded disciplines were general dentistry, orthodontics, and oral surgery, respectively (p < 0.0001). Of those referred to a dental facility, 31.84% required no clinical intervention, 28.7% received orthodontic appliance repair, and 14.3% and 11.2% had urgent dental extractions or root canal treatments. Demand on the service fluctuated through various distinct stages of the lockdown. Conclusions:There has been continuous demand for the newly introduced TD service throughout the period of the current report despite the fluctuations, with most complaints managed remotely. TD was effective and suitable for triage, service delivery, and care during the pandemic.", "doi": "10.1089/tmj.2021.0584", "pmid": "35333637", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2022-04-04T06:57:08.271Z", "modified": "2022-04-04T06:57:08.335Z"}, {"entity": "publication", "iuid": "33c17f7d64144bcbbedd0979d29ac155", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/33c17f7d64144bcbbedd0979d29ac155.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/33c17f7d64144bcbbedd0979d29ac155"}}, "title": "Interpreter-mediated interactions between people using a signed respective spoken language across distances in real time: a scoping review.", "authors": [{"family": "Warnicke", "given": "Camilla", "initials": "C"}, {"family": "Granberg", "given": "Sarah", "initials": "S"}], "type": "journal article", "published": "2022-03-24", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "volume": "22", "issue": "1", "pages": "387", "issn-l": null}, "abstract": "Communication between people who are deaf and sign and people who use a spoken language is possible by means of an interpreter. Interpreting in real time can be performed at a distance, which differs from interpreting face-to-face. Due to COVID-19, interpretation at a distance has increased.\n\nThe objective of this study was to map the existing literature to identify key characteristics by addressing the following question: What is known about interpreted mediated interactions between people using a signed respective spoken language across distances in real time?\n\nEight online databases, complemented by a search in one nonindexed journal of relevance to the review, were used to identify original studies published in 2010-2020, and 17 publications met the inclusion criteria. Charting of the data revealed insight from 17 original studies that were extracted, summarized, and reported.\n\nFour key characteristics were identified: (1) advantages and challenges in remote interpreting; (2) the need for training in remote interpreting and video relay service (VRS); (3) regulations and organizational structures of VRS; and (4) the interpreter as an active party in VRS.\n\nRemote interpreting has several challenges but also advantages. Knowledge of these kinds of interactions is limited, and further research must be initiated and realized, not least due to technological developments and the increased number of interpreting events.", "doi": "10.1186/s12913-022-07776-y", "pmid": "35331227", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-022-07776-y"}, {"db": "pmc", "key": "PMC8943107"}], "notes": [], "created": "2022-04-04T06:59:02.674Z", "modified": "2022-04-04T06:59:02.688Z"}, {"entity": "publication", "iuid": "690ccbdf2df14e38bbf07914827a68f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/690ccbdf2df14e38bbf07914827a68f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/690ccbdf2df14e38bbf07914827a68f1"}}, "title": "Association of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes.", "authors": [{"family": "Magnus", "given": "Maria C", "initials": "MC"}, {"family": "\u00d6rtqvist", "given": "Anne K", "initials": "AK"}, {"family": "Dahlqwist", "given": "Elisabeth", "initials": "E"}, {"family": "Ljung", "given": "Rickard", "initials": "R"}, {"family": "Sk\u00e5r", "given": "Fredrik", "initials": "F"}, {"family": "Oakley", "given": "Laura", "initials": "L"}, {"family": "Macsali", "given": "Ferenc", "initials": "F"}, {"family": "Pasternak", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Gjessing", "given": "H\u00e5kon K", "initials": "HK"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}], "type": "journal article", "published": "2022-03-24", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484", "volume": null, "issue": null, "pages": null}, "abstract": "Data about the safety of vaccines against SARS-CoV-2 during pregnancy are limited.\r\n\r\nTo examine the risk of adverse pregnancy outcomes after vaccination against SARS-CoV-2 during pregnancy.\r\n\r\nThis registry-based retrospective cohort study included 157 521 singleton pregnancies ending after 22 gestational weeks from January 1, 2021, until January 12, 2022 (Sweden), or January 15, 2022 (Norway). The Pregnancy Register in Sweden and the Medical Birth Registry of Norway were linked to vaccination and other registries for identification of exposure and background characteristics.\r\n\r\nData on mRNA vaccines-BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna)-and 1 viral vector vaccine-AZD1222 (AstraZeneca)-were collected from national vaccination registries.\r\n\r\nThe risk of preterm birth and stillbirth was evaluated using Cox regression models, with gestational day as the time metric and vaccination as a time-dependent exposure variable. The risk of small for gestational age, low Apgar score, and neonatal care admission was evaluated using logistic regression. Random-effects meta-analysis was used to combine results between countries.\r\n\r\nAmong the 157 521 singleton births included in the study (103 409 in Sweden and 54 112 in Norway), the mean maternal age at the time of delivery was 31 years, and 28 506 (18%) were vaccinated against SARS-CoV-2 (12.9% with BNT162b2, 4.8% with mRNA-1273, and 0.3% with AZD1222) while pregnant. A total of 0.7%, 8.3%, and 9.1% of individuals delivering were vaccinated during the first, second, and third trimester, respectively. Vaccination against SARS-CoV-2 was not significantly associated with increased risk of preterm birth (6.2 vs 4.9 per 10 000 pregnancy days; adjusted hazard ratio [aHR], 0.98 [95% CI, 0.91 to 1.05]; I2 = 0%; P for heterogeneity = .60), stillbirth (2.1 vs 2.4 per 100 000 pregnancy days; aHR, 0.86 [95% CI, 0.63 to 1.17]), small for gestational age (7.8% vs 8.5%; difference, -0.6% [95% CI, -1.3% to 0.2%]; adjusted OR [aOR], 0.97 [95% CI, 0.90 to 1.04]), low Apgar score (1.5% vs 1.6%; difference, -0.05% [95% CI, -0.3% to 0.1%]; aOR, 0.97 [95% CI, 0.87 to 1.08]), or neonatal care admission (8.5% vs 8.5%; difference, 0.003% [95% CI, -0.9% to 0.9%]; aOR, 0.97 [95% CI, 0.86 to 1.10]).\r\n\r\nIn this population-based study conducted in Sweden and Norway, vaccination against SARS-CoV-2 during pregnancy, compared with no SARS-CoV-2 vaccination during pregnancy, was not significantly associated with an increased risk of adverse pregnancy outcomes. The majority of the vaccinations were with mRNA vaccines during the second and third trimesters of pregnancy, which should be considered in interpreting the findings.", "doi": "10.1001/jama.2022.3271", "pmid": "35323851", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2790608"}], "notes": [], "created": "2022-04-04T07:01:07.549Z", "modified": "2022-04-04T07:01:45.109Z"}, {"entity": "publication", "iuid": "2c847a155f2541e8ab624cfe169d8464", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c847a155f2541e8ab624cfe169d8464.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c847a155f2541e8ab624cfe169d8464"}}, "title": "The cannabinoid receptor-1 gene interacts with stressful life events to increase the risk for problematic alcohol use.", "authors": [{"family": "Bornscheuer", "given": "Lisa", "initials": "L"}, {"family": "Lundin", "given": "Andreas", "initials": "A"}, {"family": "Forsell", "given": "Yvonne", "initials": "Y"}, {"family": "Lavebratt", "given": "Catharina", "initials": "C"}, {"family": "Melas", "given": "Philippe A", "initials": "PA"}], "type": "journal article", "published": "2022-03-23", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "4963", "issn-l": "2045-2322"}, "abstract": "Problematic alcohol use is a major contributor to the global burden of death and disabilities, and it represents a public health concern that has grown substantially following the COVID-19 pandemic. The available treatment options remain limited and to develop better pharmacotherapies for alcohol misuse we need to identify suitable biological targets. Previous research has implicated the brain's endocannabinoid system (ECS) in psychiatric and stress-related outcomes, including substance use and habituation to repeated stress. Moreover, genetic variants in the cannabinoid-1 receptor gene (CNR1; CB1R) have been associated with personality traits, which are in turn predictors of substance use disorders. To date, however, no human genome-wide association study has provided evidence for an involvement of the ECS in substance use outcomes. One reason for this ECS-related \"missing heritability\" may be unexamined gene-environment interactions. To explore this possibility, we conducted cross-sectional analyses using DNA samples and stress-exposure data from a longitudinal Swedish population-based study (N = 2,915). Specifically, we genotyped rs2023239, a functional C/T single nucleotide polymorphism in CNR1, previously reported to be associated with CNR1 binding in the brain, subjective reward following alcohol intake, and alcohol cue-elicited brain activation. Our two outcomes of interest were (i) problematic alcohol use based on the Alcohol Use Disorders Identification Test (AUDIT), and (ii) personality trait scores based on the Five Factor Model. We found no baseline association between rs2023239 and problematic alcohol use or personality traits. However, there was a clear trend for interaction between rs2023239's risk allele (C) and stressful life events (SLEs) in both childhood and adulthood, which predicted problematic alcohol use. Although not significant, there was also some indication that the risk allele interacted with child SLEs to increase scores on neuroticism. Our study supports the notion that the ECS can affect alcohol intake behaviors by interacting with life adversities and is-to the best of our knowledge-the first to focus on the interaction between CNR1 and stressors in both childhood and adulthood in humans. Further studies are warranted to confirm these findings.", "doi": "10.1038/s41598-022-08980-w", "pmid": "35322131", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-08980-w"}, {"db": "pmc", "key": "PMC8941304"}], "notes": [], "created": "2022-04-04T07:01:57.049Z", "modified": "2022-04-04T07:01:57.064Z"}, {"entity": "publication", "iuid": "036b84ea926f49ef991e707003c87736", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/036b84ea926f49ef991e707003c87736.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/036b84ea926f49ef991e707003c87736"}}, "title": "Pandemic trends in health care use: From the hospital bed to self-care with COVID-19.", "authors": [{"family": "Methi", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-7091-0806", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb34bc6f3c664b55b2240d9de0114cd4.json"}}, {"family": "Hern\u00e6s", "given": "Kjersti Helene", "initials": "KH"}, {"family": "Skyrud", "given": "Katrine Damgaard", "initials": "KD"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2022-03-23", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "3", "pages": "e0265812", "issn-l": "1932-6203"}, "abstract": "To explore whether the acute 30-day burden of COVID-19 on health care use has changed from February 2020 to February 2022.\n\nIn all Norwegians (N = 493 520) who tested positive for SARS-CoV-2 in four pandemic waves (February 26th, 2020 -February 16th, 2021 (1st wave dominated by the Wuhan strain), February 17th-July 10th, 2021 (2nd wave dominated by the Alpha variant), July 11th-December 27th, 2021 (3rd wave dominated by the Delta variant), and December 28th, 2021 -January 14th, 2022 (4th wave dominated by the Omicron variant)), we studied the age- and sex-specific share of patients (by age groups 1-19, 20-67, and 68 or more) who had: 1) Relied on self-care, 2) used outpatient care (visiting general practitioners or emergency ward for COVID-19), and 3) used inpatient care (hospitalized \u226524 hours with COVID-19).\n\nWe find a remarkable decline in the use of health care services among COVID-19 patients for all age/sex groups throughout the pandemic. From 83% [95%CI = 83%-84%] visiting outpatient care in the first wave, to 80% [81%-81%], 69% [69%-69%], and 59% [59%-59%] in the second, third, and fourth wave. Similarly, from 4.9% [95%CI = 4.7%-5.0%] visiting inpatient care in the first wave, to 3.6% [3.4%-3.7%], 1.4% [1.3%-1.4%], and 0.5% [0.4%-0.5%]. Of persons testing positive for SARS-CoV-2, 41% [41%-41%] relied on self-care in the 30 days after testing positive in the fourth wave, compared to 16% [15%-16%] in the first wave.\n\nFrom 2020 to 2022, the use of COVID-19 related outpatient care services decreased with 29%, whereas the use of COVID-19 related inpatient care services decreased with 80%.", "doi": "10.1371/journal.pone.0265812", "pmid": "35320323", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-37160"}, {"db": "pmc", "key": "PMC8942224"}], "notes": [], "created": "2022-04-04T07:02:11.806Z", "modified": "2022-04-04T07:02:11.847Z"}, {"entity": "publication", "iuid": "09c87432b4ec47b5b2ebbf1a8bad41b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/09c87432b4ec47b5b2ebbf1a8bad41b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/09c87432b4ec47b5b2ebbf1a8bad41b0"}}, "title": "Lead time of early warning by wastewater surveillance for COVID-19: geographical variations and impacting factors.", "authors": [{"family": "Kumar", "given": "Manish", "initials": "M"}, {"family": "Jiang", "given": "Guangming", "initials": "G"}, {"family": "Kumar Thakur", "given": "Alok", "initials": "A"}, {"family": "Chatterjee", "given": "Shreya", "initials": "S"}, {"family": "Bhattacharya", "given": "Tanushree", "initials": "T"}, {"family": "Mohapatra", "given": "Sanjeeb", "initials": "S"}, {"family": "Chaminda", "given": "Tushara", "initials": "T"}, {"family": "Kumar Tyagi", "given": "Vinay", "initials": "V"}, {"family": "Vithanage", "given": "Meththika", "initials": "M"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Nghiem", "given": "Long D", "initials": "LD"}, {"family": "Sarkar", "given": "Dibyendu", "initials": "D"}, {"family": "Sonne", "given": "Christian", "initials": "C"}, {"family": "Mahlknecht", "given": "J\u00fcrgen", "initials": "J"}], "type": "journal article", "published": "2022-03-23", "journal": {"title": "Chem Eng J", "issn": "1385-8947", "pages": "135936", "issn-l": null}, "abstract": "The global data on the temporal tracking of the COVID-19 through wastewater surveillance needs to be comparatively evaluated to generate a proper and precise understanding of the robustness, advantages, and sensitivity of the wastewater-based epidemiological (WBE) approach. We reviewed the current state of knowledge based on forty scientific articles pertaining to temporal variations in COVID-19 cases captured via viral RNA predictions in wastewater. This paper primarily focuses on analyzing the WBE-based temporal variation reported globally to check if the reported early warning lead-time generated through environmental surveillance is pragmatic or latent. We have compiled the geographical variations reported as lead time in various WBE reports to strike a precise correlation between COVID-19 cases and genome copies detected through wastewater surveillance, with respect to the sampling dates, separately for WASH and non-WASH countries. We highlighted sampling methods, climatic and weather conditions that significantly affected the concentration of viral SARS-CoV-2 RNA detected in wastewater, and thus the lead time reported from the various climatic zones with diverse WASH situations were different. Our major findings are: i) WBE reports around the world are not comparable, especially in terms of gene copies detected, lag-time gained between monitored RNA peak and outbreak/peak of reported case, as well as per capita RNA concentrations; ii) Varying sanitation facility and climatic conditions that impact virus degradation rate are two major interfering features limit the comparability of WBE results, and iii) WBE is better applicable to WASH countries having well-connected sewerage system.", "doi": "10.1016/j.cej.2022.135936", "pmid": "35345777", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1385-8947(22)01434-6"}, {"db": "pmc", "key": "PMC8942437"}], "notes": [], "created": "2022-04-04T06:48:56.332Z", "modified": "2022-04-04T06:48:56.349Z"}, {"entity": "publication", "iuid": "79ff04a2f9d54e14b1d6461044ebd251", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79ff04a2f9d54e14b1d6461044ebd251.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79ff04a2f9d54e14b1d6461044ebd251"}}, "title": "Interactions between glucosides of the tip of the S1 subunit of SARS-CoV-2 spike protein and dry and wet surfaces of CuO and Cu-A model for the surfaces of coinage metals.", "authors": [{"family": "Lousada", "given": "Cl\u00e1udio M", "initials": "CM"}], "type": "journal article", "published": "2022-03-23", "journal": {"title": "Colloids Surf B Biointerfaces", "issn": "1873-4367", "volume": "214", "pages": "112465", "issn-l": null}, "abstract": "Despite their importance there is little knowledge at the atomic scale on the interactions between fragments of SARS-CoV-2 and inorganic materials. Such knowledge is important to understand the survival of the virus at surfaces and for the development of antiviral materials. Here is reported a study of the interactions between glucoside monomers of the tip of the S1 subunit of SARS-CoV-2 spike protein with dry and wet surfaces of CuO and Cu, performed with dispersion corrected density functional theory-DFT. The three glucoside monomers that constitute the tip of S1: 6VSB, 6VXX and 6X6P, were adsorbed onto dry and wet CuO(111) and Cu(110) with different orientations and surface alignments. There are large differences-of up to 1.3 eV-in binding energies between these monomers and the surfaces. These differences depend on: the type of surface; if the surface is wet or dry; if the glucosidic O-atom points towards or away from the surfaces; and to a smaller extent on the surface alignment of the monomers. All monomers bind strongly to the surfaces via molecular adsorption that does not involve bond breaking in the monomers at this stage. 6VSB has the larger adsorption energies-that reach 2.2 eV-due to its larger dipole moment. Both materials bind the monomers more strongly when their surfaces are dry. At Cu(110) the bonds are on average 1 eV stronger when the surface is dry when compared to wet. The difference between dry and wet CuO(111) is smaller, in the order of 0.2 eV. Overall, it is here shown that the stability of the monomers of the tip of the spike protein of the virus is very different at different surfaces. For a given surface the larger binding energies in dry conditions could explain the differences in the surface stability of the spike protein depending on the presence of moisture.", "doi": "10.1016/j.colsurfb.2022.112465", "pmid": "35334309", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0927-7765(22)00148-5"}, {"db": "pmc", "key": "PMC8940556"}], "notes": [], "created": "2022-04-04T06:56:25.566Z", "modified": "2022-04-04T06:56:25.600Z"}, {"entity": "publication", "iuid": "645d7465d1d240e586809755a25e4438", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/645d7465d1d240e586809755a25e4438.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/645d7465d1d240e586809755a25e4438"}}, "title": "Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19.", "authors": [{"family": "Abraham", "given": "George R", "initials": "GR"}, {"family": "Kuc", "given": "Rhoda E", "initials": "RE"}, {"family": "Althage", "given": "Magnus", "initials": "M"}, {"family": "Greasley", "given": "Peter J", "initials": "PJ"}, {"family": "Ambery", "given": "Philip", "initials": "P"}, {"family": "Maguire", "given": "Janet J", "initials": "JJ"}, {"family": "Wilkinson", "given": "Ian B", "initials": "IB"}, {"family": "Hoole", "given": "Stephen P", "initials": "SP"}, {"family": "Cheriyan", "given": "Joseph", "initials": "J"}, {"family": "Davenport", "given": "Anthony P", "initials": "AP"}], "type": "journal article", "published": "2022-03-23", "journal": {"title": "J Mol Cell Cardiol", "issn": "1095-8584", "issn-l": null}, "abstract": "Virus induced endothelial dysregulation is a well-recognised feature of severe Covid-19 infection. Endothelin-1 (ET-1) is the most highly expressed peptide in endothelial cells and a potent vasoconstrictor, thus representing a potential therapeutic target. ET-1 plasma levels were measured in a cohort of 194 Covid-19 patients stratified according to the clinical severity of their illness. Hospitalised patients, including those who died and those developing acute myocardial or kidney injury, had significantly elevated ET-1 plasma levels during the acute phase of infection. The results support the hypothesis that endothelin receptor antagonists may provide clinical benefit for certain Covid-19 patients.", "doi": "10.1016/j.yjmcc.2022.03.007", "pmid": "35339512", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S0022-2828(22)00051-7"}, {"db": "pmc", "key": "PMC8941861"}], "notes": [], "created": "2022-04-04T06:50:16.165Z", "modified": "2022-04-04T06:50:22.716Z"}, {"entity": "publication", "iuid": "9f671df3137144f6a38f39a6187293ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f671df3137144f6a38f39a6187293ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f671df3137144f6a38f39a6187293ee"}}, "title": "Unraveling COVID-19: A Large-Scale Characterization of 4.5 Million COVID-19 Cases Using CHARYBDIS.", "authors": [{"family": "Kostka", "given": "Kristin", "initials": "K", "orcid": "0000-0003-2595-8736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9675cf1b775341f6a3521c7dde950262.json"}}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T", "orcid": "0000-0002-8274-0357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11fd8deb257445e7a93a0a3098b246df.json"}}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A", "orcid": "0000-0003-1202-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47f086bb6ccd49a2a5f11a32c06277c8.json"}}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Pistillo", "given": "Andrea", "initials": "A", "orcid": "0000-0002-4467-0220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/055156368b8845a0bfdc522a53cc1b0d.json"}}, {"family": "Khalid", "given": "Sara", "initials": "S"}, {"family": "Lai", "given": "Lana Y H", "initials": "LYH"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM", "orcid": "0000-0002-5630-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5162aab03bc04dafa809108461f18667.json"}}, {"family": "Dawoud", "given": "Dalia M", "initials": "DM"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Wilcox", "given": "Adam B", "initials": "AB"}, {"family": "Andryc", "given": "Alan", "initials": "A", "orcid": "0000-0002-2663-2298", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9643da291a2b4aee87e4406e36cf6d16.json"}}, {"family": "Williams", "given": "Andrew", "initials": "A"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Jung", "given": "Chi Young", "initials": "CY"}, {"family": "Harle", "given": "Christopher A", "initials": "CA"}, {"family": "Reich", "given": "Christian G", "initials": "CG", "orcid": "0000-0002-3641-055X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6982fa4f228643c6bac91609a0b336d3.json"}}, {"family": "Blacketer", "given": "Clair", "initials": "C"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Dorr", "given": "David A", "initials": "DA"}, {"family": "Burn", "given": "Edward", "initials": "E", "orcid": "0000-0002-9286-1128", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cbd60c98f85a4067aec58f7b7819800c.json"}}, {"family": "Roel", "given": "Elena", "initials": "E"}, {"family": "Tan", "given": "Eng Hooi", "initials": "EH"}, {"family": "Minty", "given": "Evan", "initials": "E"}, {"family": "DeFalco", "given": "Frank", "initials": "F"}, {"family": "de Maeztu", "given": "Gabriel", "initials": "G"}, {"family": "Lipori", "given": "Gigi", "initials": "G"}, {"family": "Alghoul", "given": "Hiba", "initials": "H", "orcid": "0000-0001-8234-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e3deb1abdf54088a29dee7675a18697.json"}}, {"family": "Zhu", "given": "Hong", "initials": "H"}, {"family": "Thomas", "given": "Jason A", "initials": "JA"}, {"family": "Bian", "given": "Jiang", "initials": "J"}, {"family": "Park", "given": "Jimyung", "initials": "J", "orcid": "0000-0002-6998-2546", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa24df935da248cc94db2e63b09a3113.json"}}, {"family": "Mart\u00ednez Rold\u00e1n", "given": "Jordi", "initials": "J"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Banda", "given": "Juan M", "initials": "JM", "orcid": "0000-0001-8499-824X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab57c692026c41f4a50b7dd737594725.json"}}, {"family": "Horcajada", "given": "Juan P", "initials": "JP", "orcid": "0000-0001-9873-5459", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b302a6caec0949c6a652ab115ae8658f.json"}}, {"family": "Kohler", "given": "Julianna", "initials": "J"}, {"family": "Shah", "given": "Karishma", "initials": "K"}, {"family": "Natarajan", "given": "Karthik", "initials": "K", "orcid": "0000-0002-9066-9431", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d68e1b4844f408991c3f79af134ca15.json"}}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Liu", "given": "Li", "initials": "L", "orcid": "0000-0002-5265-4159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/232e751324fa46f3baa9ad4c008d1b99.json"}}, {"family": "Schilling", "given": "Lisa M", "initials": "LM"}, {"family": "Recalde", "given": "Martina", "initials": "M"}, {"family": "Spotnitz", "given": "Matthew", "initials": "M"}, {"family": "Gong", "given": "Mengchun", "initials": "M"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Valveny", "given": "Neus", "initials": "N", "orcid": "0000-0003-1105-5018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b4965da861b4b41a6ed0cd38bce356a.json"}}, {"family": "Weiskopf", "given": "Nicole G", "initials": "NG"}, {"family": "Shah", "given": "Nigam", "initials": "N"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Casajust", "given": "Paula", "initials": "P", "orcid": "0000-0003-2733-5436", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8a3feb959bd461c8c4ad81fcd9dee8b.json"}}, {"family": "Park", "given": "Rae Woong", "initials": "RW"}, {"family": "Schuff", "given": "Robert", "initials": "R"}, {"family": "Seager", "given": "Sarah", "initials": "S"}, {"family": "DuVall", "given": "Scott L", "initials": "SL", "orcid": "0000-0002-4898-3865", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd524264c46548cf861123d43d57151a.json"}}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Song", "given": "Seokyoung", "initials": "S", "orcid": "0000-0002-5653-7005", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92e87edc601f49f8ad197e84d690ed36.json"}}, {"family": "Fern\u00e1ndez-Bertol\u00edn", "given": "Sergio", "initials": "S"}, {"family": "Fortin", "given": "Stephen", "initials": "S"}, {"family": "Magoc", "given": "Tanja", "initials": "T", "orcid": "0000-0001-8213-2266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c3bdfe4f6d9f4d0497d28d18a1baea2e.json"}}, {"family": "Falconer", "given": "Thomas", "initials": "T", "orcid": "0000-0001-6904-1394", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39f9b217653b4b3d8ad2b4ce30d1ca80.json"}}, {"family": "Subbian", "given": "Vignesh", "initials": "V"}, {"family": "Huser", "given": "Vojtech", "initials": "V"}, {"family": "Ahmed", "given": "Waheed-Ul-Rahman", "initials": "WU", "orcid": "0000-0003-0880-0355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27d074e0c92342d299e693d12173356c.json"}}, {"family": "Carter", "given": "William", "initials": "W", "orcid": "0000-0001-5346-3453", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8dcef685912942dca4ed5e04c68c4f9c.json"}}, {"family": "Guan", "given": "Yin", "initials": "Y"}, {"family": "Galvan", "given": "Yankuic", "initials": "Y"}, {"family": "He", "given": "Xing", "initials": "X"}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Ryan", "given": "Patrick B", "initials": "PB"}, {"family": "Suchard", "given": "Marc A", "initials": "MA", "orcid": "0000-0001-9818-479X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f920e0e55c94e91b4dcff796bd24246.json"}}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D", "orcid": "0000-0002-3950-6346", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1c3f99e11244a3b90ba881356d3e259.json"}}], "type": "journal article", "published": "2022-03-22", "journal": {"title": "CLEP", "issn": "1179-1349", "volume": "14", "pages": "369-384", "issn-l": null}, "abstract": "Routinely collected real world data (RWD) have great utility in aiding the novel coronavirus disease (COVID-19) pandemic response. Here we present the international Observational Health Data Sciences and Informatics (OHDSI) Characterizing Health Associated Risks and Your Baseline Disease In SARS-COV-2 (CHARYBDIS) framework for standardisation and analysis of COVID-19 RWD.\n\nWe conducted a descriptive retrospective database study using a federated network of data partners in the United States, Europe (the Netherlands, Spain, the UK, Germany, France and Italy) and Asia (South Korea and China). The study protocol and analytical package were released on 11th June 2020 and are iteratively updated via GitHub. We identified three non-mutually exclusive cohorts of 4,537,153 individuals with a clinical COVID-19 diagnosis or positive test, 886,193 hospitalized with COVID-19, and 113,627 hospitalized with COVID-19 requiring intensive services.\n\nWe aggregated over 22,000 unique characteristics describing patients with COVID-19. All comorbidities, symptoms, medications, and outcomes are described by cohort in aggregate counts and are readily available online. Globally, we observed similarities in the USA and Europe: more women diagnosed than men but more men hospitalized than women, most diagnosed cases between 25 and 60 years of age versus most hospitalized cases between 60 and 80 years of age. South Korea differed with more women than men hospitalized. Common comorbidities included type 2 diabetes, hypertension, chronic kidney disease and heart disease. Common presenting symptoms were dyspnea, cough and fever. Symptom data availability was more common in hospitalized cohorts than diagnosed.\n\nWe constructed a global, multi-centre view to describe trends in COVID-19 progression, management and evolution over time. By characterising baseline variability in patients and geography, our work provides critical context that may otherwise be misconstrued as data quality issues. This is important as we perform studies on adverse events of special interest in COVID-19 vaccine surveillance.", "doi": "10.2147/CLEP.S323292", "pmid": "35345821", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "323292"}, {"db": "pmc", "key": "PMC8957305"}], "notes": [], "created": "2022-04-04T06:48:36.538Z", "modified": "2022-04-04T06:48:37.014Z"}, {"entity": "publication", "iuid": "ca51b638da9740ca8c52978f961759b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ca51b638da9740ca8c52978f961759b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ca51b638da9740ca8c52978f961759b1"}}, "title": "Current Approaches to Vaccine Safety Using Observational Data: A Rationale for the EUMAEUS (Evaluating Use of Methods for Adverse Events Under Surveillance-for Vaccines) Study Design.", "authors": [{"family": "Lai", "given": "Lana Yh", "initials": "LY"}, {"family": "Arshad", "given": "Faaizah", "initials": "F"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "Li", "given": "Xintong", "initials": "X"}, {"family": "Dawoud", "given": "Dalia", "initials": "D"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Pratt", "given": "Nicole", "initials": "N"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Prieto-Alhambra", "given": "Dani", "initials": "D"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Schuemie", "given": "Martijn J", "initials": "MJ"}], "type": "journal article", "published": "2022-03-22", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "issn-l": "1663-9812", "volume": "13", "issue": null, "pages": "837632"}, "abstract": "Post-marketing vaccine safety surveillance aims to detect adverse events following immunization in a population. Whether certain methods of surveillance are more precise and unbiased in generating safety signals is unclear. Here, we synthesized information from existing literature to provide an overview of the strengths, weaknesses, and clinical applications of epidemiologic and analytical methods used in vaccine monitoring, focusing on cohort, case-control and self-controlled designs. These designs are proposed to be evaluated in the EUMAEUS (Evaluating Use of Methods for Adverse Event Under Surveillance-for vaccines) study because of their widespread use and potential utility. Over the past decades, there have been an increasing number of epidemiological study designs used for vaccine safety surveillance. While traditional cohort and case-control study designs remain widely used, newer, novel designs such as the self-controlled case series and self-controlled risk intervals have been developed. Each study design comes with its strengths and limitations, and the most appropriate study design will depend on availability of resources, access to records, number and distribution of cases, and availability of population coverage data. Several assumptions have to be made while using the various study designs, and while the goal is to mitigate any biases, violations of these assumptions are often still present to varying degrees. In our review, we discussed some of the potential biases (i.e., selection bias, misclassification bias and confounding bias), and ways to mitigate them. While the types of epidemiological study designs are well established, a comprehensive comparison of the analytical aspects (including method evaluation and performance metrics) of these study designs are relatively less well studied. We summarized the literature, reporting on two simulation studies, which compared the detection time, empirical power, error rate and risk estimate bias across the above-mentioned study designs. While these simulation studies provided insights on the analytic performance of each of the study designs, its applicability to real-world data remains unclear. To bridge that gap, we provided the rationale of the EUMAEUS study, with a brief description of the study design; and how the use of real-world multi-database networks can provide insights into better methods evaluation and vaccine safety surveillance.", "doi": "10.3389/fphar.2022.837632", "pmid": "35392566", "labels": {"Category: Vaccines": null, "Category: Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8980923"}, {"db": "pii", "key": "837632"}], "notes": [], "created": "2023-01-13T09:52:58.045Z", "modified": "2023-01-13T09:53:58.946Z"}, {"entity": "publication", "iuid": "c621ce38cce94a0bb966a7b453952c00", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c621ce38cce94a0bb966a7b453952c00.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c621ce38cce94a0bb966a7b453952c00"}}, "title": "BMI, sex and outcomes in hospitalised patients in western Sweden during the COVID-19 pandemic.", "authors": [{"family": "Lindgren", "given": "Martin", "initials": "M"}, {"family": "Toska", "given": "Triantafyllia", "initials": "T"}, {"family": "Alex", "given": "Christian", "initials": "C"}, {"family": "Lundberg", "given": "Christina E", "initials": "CE"}, {"family": "Cronie", "given": "Ottmar", "initials": "O"}, {"family": "Rosengren", "given": "Annika", "initials": "A"}, {"family": "Adiels", "given": "Martin", "initials": "M"}, {"family": "Sj\u00f6land", "given": "Helen", "initials": "H"}], "type": "journal article", "published": "2022-03-22", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "4918", "issn-l": "2045-2322"}, "abstract": "High body mass index (BMI) is associated with severe COVID-19 but findings regarding the need of intensive care (IC) and mortality are mixed. Using electronic health records, we identified all patients in western Sweden hospitalised with COVID-19 to evaluate 30-day mortality or assignment to IC. Adjusted logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for outcomes. Of totally 9761 patients, BMI was available in 7325 (75%), included in the study. There was a marked inverse association between BMI and age (underweight and normal weight patients were on average 78 and 75 years, whereas overweight and obese were 68 and 62 years). While older age, male sex and several comorbidities associated with higher mortality after multivariable adjustment, BMI did not. However, BMI \u2265 30 kg/m2 (OR 1.46, 95% CI 1.21-1.75) was associated with need of IC; this association was restricted to women (BMI \u2265 30; OR 1.96 (95% CI 1.41-2.73), and not significant in men; OR 1.22 (95% CI 0.97-1.54). In this comprehensive hospital population with COVID-19, BMI was not associated with 30-day mortality risk. Among the obese, women, but not men, had a higher risk of assignment to IC.", "doi": "10.1038/s41598-022-09027-w", "pmid": "35318438", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8939489"}, {"db": "pii", "key": "10.1038/s41598-022-09027-w"}], "notes": [], "created": "2022-04-04T07:10:13.488Z", "modified": "2023-01-13T13:51:25.566Z"}, {"entity": "publication", "iuid": "7bd80e6ae702469a84e47666eea3e837", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7bd80e6ae702469a84e47666eea3e837.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7bd80e6ae702469a84e47666eea3e837"}}, "title": "Psychological Health and Digital Social Participation of the Older Adults during the COVID-19 Pandemic in Blekinge, Sweden-An Exploratory Study.", "authors": [{"family": "Ghazi", "given": "Sarah Nauman", "initials": "SN", "orcid": "0000-0001-8114-8813", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/100ab0ff0c8d4d0cbd2c29e1e9639099.json"}}, {"family": "Anderberg", "given": "Peter", "initials": "P", "orcid": "0000-0001-9870-8477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b827b4a21b643908e4f069979dd948b.json"}}, {"family": "Berglund", "given": "Johan Sanmartin", "initials": "JS", "orcid": "0000-0003-4312-2246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ecd51160e1e412baa035f8e78150d6e.json"}}, {"family": "Berner", "given": "Jessica", "initials": "J", "orcid": "0000-0002-2848-2377", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d14099d99cf4840b3f27c24929ffcb1.json"}}, {"family": "Dallora", "given": "Ana Luiza", "initials": "AL", "orcid": "0000-0002-6752-017X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc6a17faba5a434ba9b6fc8cfbb6a1dc.json"}}], "type": "journal article", "published": "2022-03-21", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "6", "issn-l": null}, "abstract": "COVID-19 has affected the psychological health of older adults directly and indirectly through recommendations of social distancing and isolation. Using the internet or digital tools to participate in society, one might mitigate the effects of COVID-19 on psychological health. This study explores the social participation of older adults through internet use as a social platform during COVID-19 and its relationship with various psychological health aspects. In this study, we used the survey as a research method, and we collected data through telephonic interviews; and online and paper-based questionnaires. The results showed an association of digital social participation with age and feeling lack of company. Furthermore, in addition, to the increase in internet use in older adults in Sweden during COVID-19, we conclude that digital social participation is essential to maintain psychological health in older adults.", "doi": "10.3390/ijerph19063711", "pmid": "35329398", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8954168"}, {"db": "pii", "key": "ijerph19063711"}], "notes": [], "created": "2022-04-04T06:59:37.623Z", "modified": "2023-01-13T13:54:33.282Z"}, {"entity": "publication", "iuid": "0086246b36c84a929b363e65a2c76447", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0086246b36c84a929b363e65a2c76447.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0086246b36c84a929b363e65a2c76447"}}, "title": "No man is an island: management of the emergency response to the SARS-CoV-2 (COVID-19) outbreak in a large public decentralised service delivery organisation.", "authors": [{"family": "Ohrling", "given": "Mikael", "initials": "M"}, {"family": "Solberg Carlsson", "given": "Karin", "initials": "K"}, {"family": "Brommels", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2022-03-21", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "volume": "22", "issue": "1", "pages": "371", "issn-l": null}, "abstract": "We wanted to better understand whether and how agility can be achieved in a decentralised service delivery organisation in Sweden. The pandemic outbreak of SARS-Cov-2 (Covid-19) provided an opportunity to assess decentralisation as a strategy to improve the responsiveness of healthcare and at the same time handle an unpredictable and unexpected event.\n\nData from in-depth interviews with a crisis management team (n = 23) and free text answers in a weekly survey to subordinated clinical directors, i.e. unit managers, (n = 108) were scrutinised in a directed content analysis. Dynamic capabilities as a prerequisite for dynamic effectiveness, understood as reaching strategic and operative effectiveness simultaneously, were explored by using three frameworks for dynamic effectiveness, dynamic capabilities and delegated authority in a decentralised organisation.\n\nUnpredictable events, such as the pandemic Covid-19 outbreak, demand a high grade of ability to be flexible. We find that a high degree of operational effectiveness, which is imperative in an emergency situation, also is a driver of seeking new strategic positions to even better meet new demands. The characteristics of the dynamic capabilities evolving from this process are described and discussed in relation to decentralisation, defined by decision space, organisational and individual capacity as well as accountability. We present arguments supporting that a decentralised management model can facilitate the agility required in an emergency.\n\nThis study is, to our knowledge, the first of its kind where a decentralised management model in a service delivery organisation in healthcare is studied in relation to crisis management. Although stemming from one organisation, our findings indicating the value of decentralisation in situations of crisis are corroborated by theory, suggesting that they could be relevant in other organisational settings also.", "doi": "10.1186/s12913-022-07716-w", "pmid": "35313891", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-022-07716-w"}, {"db": "pmc", "key": "PMC8935606"}], "notes": [], "created": "2022-03-23T06:14:10.289Z", "modified": "2022-04-04T07:11:17.984Z"}, {"entity": "publication", "iuid": "fb52b1f6da5e4ee0881b3ae3dfb465f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb52b1f6da5e4ee0881b3ae3dfb465f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb52b1f6da5e4ee0881b3ae3dfb465f4"}}, "title": "Improved Binding Affinity of Omicron's Spike Protein for the Human Angiotensin-Converting Enzyme 2 Receptor Is the Key behind Its Increased Virulence.", "authors": [{"family": "Kumar", "given": "Rajender", "initials": "R"}, {"family": "Murugan", "given": "Natarajan Arul", "initials": "NA", "orcid": "0000-0003-0185-5724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/293acfd743f94993bd6aca57b01cd604.json"}}, {"family": "Srivastava", "given": "Vaibhav", "initials": "V", "orcid": "0000-0003-1877-4154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f6299b3ddf14b88866157ec4b4113b0.json"}}], "type": "journal article", "published": "2022-03-21", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "23", "issue": "6", "issn-l": null}, "abstract": "The new variant of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), Omicron, has been quickly spreading in many countries worldwide. Compared to the original virus, Omicron is characterized by several mutations in its genomic region, including the spike protein's receptor-binding domain (RBD). We have computationally investigated the interaction between the RBD of both the wild type and Omicron variant of SARS-CoV-2 with the human angiotensin-converting enzyme 2 (hACE2) receptor using molecular dynamics and molecular mechanics-generalized Born surface area (MM-GBSA)-based binding free energy calculations. The mode of the interaction between Omicron's RBD with the hACE2 receptor is similar to the original SARS-CoV-2 RBD except for a few key differences. The binding free energy difference shows that the spike protein of Omicron has an increased affinity for the hACE2 receptor. The mutated residues in the RBD showed strong interactions with a few amino acid residues of hACE2. More specifically, strong electrostatic interactions (salt bridges) and hydrogen bonding were observed between R493 and R498 residues of the Omicron RBD with D30/E35 and D38 residues of the hACE2, respectively. Other mutated amino acids in the Omicron RBD, e.g., S496 and H505, also exhibited hydrogen bonding with the hACE2 receptor. A pi-stacking interaction was also observed between tyrosine residues (RBD-Tyr501: hACE2-Tyr41) in the complex, which contributes majorly to the binding free energies and suggests that this is one of the key interactions stabilizing the formation of the complex. The resulting structural insights into the RBD:hACE2 complex, the binding mode information within it, and residue-wise contributions to the free energy provide insight into the increased transmissibility of Omicron and pave the way to design and optimize novel antiviral agents.", "doi": "10.3390/ijms23063409", "pmid": "35328828", "labels": {"Category: Health": null, "Category: Omicron VoC": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijms23063409"}, {"db": "pmc", "key": "PMC8955673"}], "notes": [], "created": "2022-04-04T06:59:54.410Z", "modified": "2022-04-04T06:59:54.512Z"}, {"entity": "publication", "iuid": "ecdade19e7e247f18497e4508d9ea7b6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ecdade19e7e247f18497e4508d9ea7b6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ecdade19e7e247f18497e4508d9ea7b6"}}, "title": "Fear of COVID-19 and its association with mental health-related factors: systematic review and meta-analysis.", "authors": [{"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Ohayon", "given": "Maurice M", "initials": "MM", "orcid": "0000-0002-2757-5440", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11af7871e5f948c0b730031f9b2fc03f.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2022-03-21", "journal": {"title": "BJPsych Open", "issn": "2056-4724", "volume": "8", "issue": "2", "pages": "e73", "issn-l": null}, "abstract": "The severity of COVID-19 remains high worldwide. Therefore, millions of individuals are likely to suffer from fear of COVID-19 and related mental health factors.\n\nThe present systematic review and meta-analysis aimed to synthesize empirical evidence to understand fear of COVID-19 and its associations with mental health-related problems during this pandemic period.\n\nRelevant studies were searched for on five databases (Scopus, ProQuest, EMBASE, PubMed Central, and ISI Web of Knowledge), using relevant terms (COVID-19-related fear, anxiety, depression, mental health-related factors, mental well-being and sleep problems). All studies were included for analyses irrespective of their methodological quality, and the impact of quality on pooled effect size was examined by subgroup analysis.\n\nThe meta-analysis pooled data from 91 studies comprising 88 320 participants (mean age 38.88 years; 60.66% females) from 36 countries. The pooled estimated mean of fear of COVID-19 was 13.11 (out of 35), using the Fear of COVID-19 Scale. The associations between fear of COVID-19 and mental health-related factors were mostly moderate (Fisher's z = 0.56 for mental health-related factors; 0.54 for anxiety; 0.42 for stress; 0.40 for depression; 0.29 for sleep problems and -0.24 for mental well-being). Methodological quality did not affect these associations.\n\nFear of COVID-19 has associations with various mental health-related factors. Therefore, programmes for reducing fear of COVID-19 and improving mental health are needed.", "doi": "10.1192/bjo.2022.26", "pmid": "35307051", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2056472422000266"}, {"db": "pmc", "key": "PMC8943231"}], "notes": [], "created": "2022-03-23T06:15:25.083Z", "modified": "2022-04-04T07:11:41.809Z"}, {"entity": "publication", "iuid": "2465b2a255c449c98dbe9eb9e8e85164", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2465b2a255c449c98dbe9eb9e8e85164.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2465b2a255c449c98dbe9eb9e8e85164"}}, "title": "The Swedish gamble: trust in the government and self-efficacy in the battle to combat COVID-19.", "authors": [{"family": "Hassan", "given": "Mohammed Salah", "initials": "MS", "orcid": "0000-0002-1742-2790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e712ec5774ec44d5a84da8da847ec9e9.json"}}, {"family": "Al Halbusi", "given": "Hussam", "initials": "H"}, {"family": "Razali", "given": "Asbah", "initials": "A"}, {"family": "Ariffin", "given": "Raja Noriza Raja", "initials": "RNR"}, {"family": "Williams", "given": "Kent A", "initials": "KA"}], "type": "journal article", "published": "2022-03-19", "journal": {"title": "Curr Psychol", "issn": "1046-1310", "pages": "1-16", "issn-l": null}, "abstract": "Governments around the world have issued movement restrictions and quarantines to combat the SARS-CoV-2 (COVID-19) pandemic. However, the Swedish government has not implemented such measures but has depended on individual responsibility. The extent to which individuals have been encouraged to trust in and be satisfied with government strategies and adopt personal health measures, such as social isolation, remains unclear. This study examines the direct effects of trust in the government and risk perception on self-efficacy. Most importantly, this study intends to explore whether satisfaction with government measures strengthens the relationships between 1) trust in the government and self-efficacy and 2) risk perception and self-efficacy. We test our suggested hypotheses using survey data obtained from 403 Swedish citizens living in Sweden. As predicted, the findings indicate that trust in the government and risk perception positively impact individual self-efficacy. Additionally, the findings reveal that satisfaction with government measures strengthens these relationships; more precisely, the impact of trust in the government and risk perception under a high level of individual satisfaction with government measures is much more positive than that under a low satisfaction level. In practice, a focus on implementing successful policies and excellent individual self-efficacy is required to halt the pandemic, and the findings indicate that combining strictly attentive and adaptive individual strategies with government strategies can minimize the spread of infection.", "doi": "10.1007/s12144-022-02947-w", "pmid": "35340688", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "2947"}, {"db": "pmc", "key": "PMC8933660"}], "notes": [], "created": "2022-04-04T06:49:57.235Z", "modified": "2022-04-04T06:49:57.294Z"}, {"entity": "publication", "iuid": "6221bb142023474cbb6069d730245cce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6221bb142023474cbb6069d730245cce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6221bb142023474cbb6069d730245cce"}}, "title": "Small business managers and Covid-19-The role of a sense of coherence and general resistance resources in coping with stressors.", "authors": [{"family": "Hansson", "given": "Josefine", "initials": "J", "orcid": "0000-0001-6385-1556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04f28c63354f4e11b27b8abdab4c58b7.json"}}, {"family": "Landstad", "given": "Bodil J", "initials": "BJ"}, {"family": "Vinberg", "given": "Stig", "initials": "S"}, {"family": "Hedlund", "given": "Marianne", "initials": "M", "orcid": "0000-0002-1789-2477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d8e2939573845109d470f05b8314cee.json"}}, {"family": "Tjulin", "given": "\u00c5sa", "initials": "\u00c5"}], "type": "journal article", "published": "2022-03-18", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "17", "issue": "3", "pages": "e0265029"}, "abstract": "The response of small business managers to an external event such as the pandemic can have a profound effect on the work environment, health and well-being for themselves and their employees. Previous research on small business managers during the pandemic has mainly focused on traditional pathogenic effects, and there is a lack of studies looking at the issue from a salutogenic health promotion perspective. The aim of this study is to explore whether a sense of coherence and general resistance resources were experienced by small business managers in Sweden and Norway during the Covid-19 pandemic.\r\n\r\nA qualitative design was applied through exploratory interviews with 16 managers of small businesses in Sweden and Norway. A content analysis of the interviews was conducted using the sense of coherence concept by Aaron Antonovsky, with the three main components of comprehensibility, meaningfulness and manageability acting as a conceptual framework for the analysis process.\r\n\r\nWithin the three main sense-of-coherence categories, six general resistance resources were identified as being important for the managers to handle uncertainty during the pandemic. These were understanding rules and regulations, social support, optimism, proactivity, problem-solving and flexibility and cooperation.\r\n\r\nThe small business managers handled the pandemic in a way that worked well in their contexts, and the pandemic generally did not have a negative effect on their businesses or themselves. A salutogenic approach, through which the managers focused on identifying and using resources, was an important factor for managing stressors and adversity during the pandemic. Hence, the concept of salutogenesis may be used as an intervention to foster better health in small businesses, both at a personal and organisational level in order to handle future challenges effectively.", "doi": "10.1371/journal.pone.0265029", "pmid": "35302995", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-40328"}, {"db": "pmc", "key": "PMC8932562"}], "notes": [], "created": "2022-04-04T07:20:30.481Z", "modified": "2022-11-22T05:39:10.634Z"}, {"entity": "publication", "iuid": "d40245a393af4e258f8aeb8480b67790", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d40245a393af4e258f8aeb8480b67790.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d40245a393af4e258f8aeb8480b67790"}}, "title": "Associations between hemostatic markers and mortality in COVID-19 - Compounding effects of D-dimer, antithrombin and PAP complex.", "authors": [{"family": "Bokn\u00e4s", "given": "Niklas", "initials": "N"}, {"family": "Laine", "given": "Cia", "initials": "C"}, {"family": "Hillarp", "given": "Andreas", "initials": "A"}, {"family": "Macwan", "given": "Ankit S", "initials": "AS"}, {"family": "Gustafsson", "given": "Kerstin M", "initials": "KM"}, {"family": "Lindahl", "given": "Tomas L", "initials": "TL"}, {"family": "Holmstr\u00f6m", "given": "Margareta", "initials": "M"}], "type": "journal article", "published": "2022-03-18", "journal": {"title": "Thromb Res", "issn": "1879-2472", "volume": "213", "pages": "97-104", "issn-l": "0049-3848"}, "abstract": "In this single-center cohort study, we applied a panel of laboratory markers to characterize hemostatic function in 217 consecutive patients that underwent testing for COVID-19 as they were admitted to Link\u00f6ping University Hospital between April and June 2020. In the 96 patients that tested positive for SARS-CoV-2 (COVID-19+), the cumulative incidences of death and venous thromboembolism were 24.0% and 19.8% as compared to 12.4% (p = 0.031) and 11.6% (p = 0.13) in the 121 patients that tested negative (COVID-19-). In COVID-19+ patients, we found pronounced increases in plasma levels of von Willebrand factor (vWF) and fibrinogen. Excess mortality was observed in COVID-19+ patients with the following aberrations in hemostatic markers: high D-dimer, low antithrombin or low plasmin-antiplasmin complex (PAP) formation, with Odds Ratios (OR) for death of 4.7 (95% confidence interval (CI95) 1.7-12.9; p = 0.003) for D-dimer >0.5 mg/L, 5.9 (CI95 1.8-19.7; p = 0.004) for antithrombin (AT) \u02c20.85 kIU/l and 4.9 (CI95 1.3-18.3; p = 0.019) for PAP < 1000 \u03bcg/L. Compounding increases in mortality was observed in COVID-19+ patients with combined defects in markers of fibrinolysis and coagulation, with ORs for death of 15.7 (CI95 4.3-57; p < 0.001) for patients with PAP <1000 \u03bcg/L and D-dimer >0.5 mg/L and 15.5 (CI95 2.8-87, p = 0.002) for patients with PAP <1000 \u03bcg/L and AT \u02c20.85 kIU/L. We observed an elevated fraction of incompletely degraded D-dimer fragments in COVID-19+ patients with low PAP, indicating impaired fibrinolytic breakdown of cross-linked fibrin.", "doi": "10.1016/j.thromres.2022.03.013", "pmid": "35316719", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0049-3848(22)00090-1"}, {"db": "pmc", "key": "PMC8930184"}], "notes": [], "created": "2022-03-23T06:13:34.273Z", "modified": "2022-04-04T07:11:04.402Z"}, {"entity": "publication", "iuid": "4b29cfb92af74ba9bb0ae2d414a33423", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b29cfb92af74ba9bb0ae2d414a33423.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b29cfb92af74ba9bb0ae2d414a33423"}}, "title": "Digit ratios and their asymmetries as risk factors of developmental instability and hospitalization for COVID-19.", "authors": [{"family": "Kasielska-Trojan", "given": "A", "initials": "A"}, {"family": "Manning", "given": "J T", "initials": "JT"}, {"family": "Jab\u0142kowski", "given": "M", "initials": "M"}, {"family": "Bia\u0142kowska-Warzecha", "given": "J", "initials": "J"}, {"family": "Hirschberg", "given": "A L", "initials": "AL"}, {"family": "Antoszewski", "given": "B", "initials": "B"}], "type": "journal article", "published": "2022-03-17", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "4573", "issn-l": "2045-2322"}, "abstract": "COVID-19 presents with mild symptoms in the majority of patients but in a minority it progresses to acute illness and hospitalization. Here we consider whether markers for prenatal sex hormones and postnatal stressors on developmental instability, i.e. digit ratios and their directional and unsigned asymmetries, are predictive of hospitalization. We focus on six ratios: 2D:3D; 2D:4D; 2D:5D; 3D:4D; 3D:5D; 4D:5D and compare hospitalized patient and control means for right, and left ratios, directional asymmetries (right-left) and unsigned asymmetries [|(right-left)|]. There were 54 patients and 100 controls. We found (i) patients differed in their digit ratios from controls (patients > controls) in all three ratios that included 5D (2D:5D, 3D:5D and 4D:5D) with small to medium effect sizes (d = 0.3 to 0.64), (ii) they did not differ in their directional asymmetries, and (iii) patients had greater |(right-left)| asymmetry than controls for 2D:4D (d = .74) , and all ratios that included 5D; 2D:5D (d = 0.66), 3D:5D (d = .79), 4D:5D (d = 0.47). The Composite Asymmetry of the two largest effects (2D:4D + 3D:5D) gave a patient and control difference with effect size d = 1.04. All patient versus control differences were independent of sex. We conclude that digit ratio patterns differ between patients and controls and this was most evident in ratios that included 5D. Large |(right-left)| asymmetries in the patients are likely to be a marker for postnatal stressors resulting in developmental perturbations and for potential severity of COVID-19.", "doi": "10.1038/s41598-022-08646-7", "pmid": "35301404", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-08646-7"}, {"db": "pmc", "key": "PMC8931101"}], "notes": [], "created": "2022-04-04T07:21:16.821Z", "modified": "2022-04-04T07:21:16.836Z"}, {"entity": "publication", "iuid": "149cb301610f424897b07ab7001e9771", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/149cb301610f424897b07ab7001e9771.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/149cb301610f424897b07ab7001e9771"}}, "title": "Prophylactic anticoagulation with low molecular weight heparin in COVID-19: cohort studies in Denmark and Sweden.", "authors": [{"family": "Lund", "given": "Lars Christian", "initials": "LC"}, {"family": "Hedberg", "given": "Pontus", "initials": "P"}, {"family": "Andreasen", "given": "Anne Helms", "initials": "AH"}, {"family": "Petersen", "given": "Janne", "initials": "J"}, {"family": "Petersen", "given": "Tonny Studsgaard", "initials": "TS"}, {"family": "Potteg\u00e5rd", "given": "Anton", "initials": "A"}, {"family": "Bodilsen", "given": "Jacob", "initials": "J"}, {"family": "Naucler", "given": "Pontus", "initials": "P"}, {"family": "Hallas", "given": "Jesper", "initials": "J"}, {"family": "Jimenez-Solem", "given": "Espen", "initials": "E"}], "type": "journal article", "published": "2022-03-16", "journal": {"title": "Clin Microbiol Infect", "issn": "1469-0691", "issn-l": null}, "abstract": "To evaluate safety and effectiveness of prophylactic anticoagulation with low molecular weight heparin (LMWH) in individuals hospitalised for COVID-19.\n\nUsing healthcare records from the capital region of Denmark (March 2020-February 2021) and Karolinska University Hospital in Sweden (February 2020-September 2021), we conducted an observational cohort study comparing clinical outcomes 30 days after admission among individuals hospitalised for COVID-19 starting prophylactic LMWH during the first 48 hours of hospitalisation with outcomes among those not receiving prophylactic anticoagulation. We used inverse probability weighting to adjust for confounders and bias due to missing information. Risk ratios, risk differences and robust 95% confidence intervals (CI) were estimated using binomial regression. Country-specific risk ratios were pooled using random-effects meta-analysis.\n\nWe included 1692 and 1868 individuals in the Danish and Swedish cohorts. Of these, 771 (46%) and 1167 (62%) received prophylactic LMWH up to 48 hours after admission. The combined mortality in Denmark and Sweden was 12% (N=432) and the pooled risk ratio was 0.89 (CI 0.61-1.29) comparing individuals who received LMWH to those who did not. The relative risk of ICU admission was 1.12 (CI 0.85-1.48), while we observed no increased risk of bleeding (RR 0.60, 0.14-2.59). The relative risk of venous thromboembolism was 0.68 (CI: 0.33-1.38) in Sweden. Less than 5 VTE events were observed among individuals receiving LMWH in Denmark, preventing a meaningful analysis.\n\nWe found no benefit on mortality with prophylactic LMWH and no increased risk of bleeding among COVID-19 patients receiving prophylactic LMWH.", "doi": "10.1016/j.cmi.2022.03.006", "pmid": "35306190", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(22)00145-8"}, {"db": "pmc", "key": "PMC8926439"}], "notes": [], "created": "2022-03-23T06:15:58.305Z", "modified": "2022-04-04T07:11:58.553Z"}, {"entity": "publication", "iuid": "c535676ff3714e12a544dc95d815f7e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c535676ff3714e12a544dc95d815f7e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c535676ff3714e12a544dc95d815f7e7"}}, "title": "Exposure-lag response of air temperature on COVID-19 incidence in twelve Italian cities: A meta-analysis.", "authors": [{"family": "Fong", "given": "Fang Chyi", "initials": "FC"}, {"family": "Smith", "given": "Daniel Robert", "initials": "DR"}], "type": "journal article", "published": "2022-03-16", "journal": {"title": "Environ Res", "issn": "1096-0953", "pages": "113099", "volume": "212", "issue": "Pt A", "issn-l": "0013-9351"}, "abstract": "The exposure-lag response of air temperature on daily COVID-19 incidence is unclear and there have been concerns regarding the robustness of previous studies. Here we present an analysis of high spatial and temporal resolution using the distributed lag non-linear modelling (DLNM) framework. Utilising nearly two years' worth of data, we fit statistical models to twelve Italian cities to quantify the delayed effect of air temperature on daily COVID-19 incidence, accounting for several categories of potential confounders (meteorological, air quality and non-pharmaceutical interventions). Coefficients and covariance matrices for the temperature term were then synthesised using random effects meta-analysis to yield pooled estimates of the exposure-lag response with effects presented as the relative risk (RR) and cumulative RR (RRcum). The cumulative exposure response curve was non-linear, with peak risk at 15.1 \u00b0C and declining risk at progressively lower and higher temperatures. The lowest RRcum at 0.2 \u00b0C is 0.72 [0.56,0.91] times that of the highest risk. Due to this non-linearity, the shape of the lag response curve necessarily varied by temperature. This work suggests that on a given day, air temperature approximately 15 \u00b0C maximises the incidence of COVID-19, with the effects distributed in the subsequent ten days or more.", "doi": "10.1016/j.envres.2022.113099", "pmid": "35305982", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0013-9351(22)00426-1"}, {"db": "pmc", "key": "PMC8925100"}], "notes": [], "created": "2022-03-23T06:16:18.024Z", "modified": "2022-04-04T07:12:12.668Z"}, {"entity": "publication", "iuid": "426e7a01cb93430a878e86cc81edeaf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/426e7a01cb93430a878e86cc81edeaf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/426e7a01cb93430a878e86cc81edeaf3"}}, "title": "Assessing alternative indicators for Covid-19 policy evaluation, with a counterfactual for Sweden.", "authors": [{"family": "Latour", "given": "Chiara", "initials": "C"}, {"family": "Peracchi", "given": "Franco", "initials": "F", "orcid": "0000-0002-4532-6173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b566a37c94d948abbfbe9edc508cc440.json"}}, {"family": "Spagnolo", "given": "Giancarlo", "initials": "G", "orcid": "0000-0003-4117-6283", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd25c165fd0d474d9c6dc385bd27939b.json"}}], "type": "journal article", "published": "2022-03-16", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "3", "pages": "e0264769", "issn-l": "1932-6203"}, "abstract": "Using the synthetic control method, we construct counterfactuals for what would have happened if Sweden had imposed a lockdown during the first wave of the COVID-19 epidemic. We consider eight different indicators, including a novel one that we construct by adjusting recorded daily COVID-19 deaths to account for weakly excess mortality. Correcting for data problems and re-optimizing the synthetic control for each indicator, we find that a lockdown would have had sizable effects within one week. The much longer delay estimated by two previous studies focusing on the number of positives cases is mainly driven by the extremely low testing frequency that prevailed in Sweden in the first months of the epidemic. This result appears relevant for choosing the timing of future lockdowns and highlights the importance of looking at several indicators to derive robust conclusions. We also find that our novel indicator is effective in correcting errors in the COVID-19 deaths series and that the quantitative effects of the lockdown are stronger than previously estimated.", "doi": "10.1371/journal.pone.0264769", "pmid": "35294472", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8926176"}, {"db": "pii", "key": "PONE-D-21-23290"}], "notes": [], "created": "2023-01-13T13:38:34.149Z", "modified": "2023-01-13T13:38:34.233Z"}, {"entity": "publication", "iuid": "cd0e2a2c31544e2496d2efd2a4b773e3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd0e2a2c31544e2496d2efd2a4b773e3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd0e2a2c31544e2496d2efd2a4b773e3"}}, "title": "Application of the SARS-CoV-2-S1 ACE-2 receptor interaction as the basis of the fully automated assay to detect neutralizing SARS-CoV-2-S1 antibodies in blood samples.", "authors": [{"family": "Filchtinski", "given": "Daniel", "initials": "D"}, {"family": "Sundberg", "given": "Magnus", "initials": "M"}, {"family": "Berthold", "given": "Heike", "initials": "H"}, {"family": "Steller", "given": "Laura", "initials": "L"}, {"family": "Kayser", "given": "Jos\u00e9", "initials": "J"}, {"family": "Holz", "given": "Sanja", "initials": "S"}, {"family": "Hinze", "given": "Mario", "initials": "M"}, {"family": "Braeutigam", "given": "Oxana", "initials": "O"}, {"family": "Schulte-Pelkum", "given": "Johannes", "initials": "J"}, {"family": "Fiedler", "given": "Raimund", "initials": "R"}], "type": "journal article", "published": "2022-03-15", "journal": {"title": "J Immunol Methods", "issn": "1872-7905", "volume": "504", "pages": "113258", "issn-l": null}, "abstract": "A quantitative, high throughput, fully automated diagnostic method for the detection of neutralizing anti-SARS-CoV-2 antibodies was developed on the Phadia system based on the interaction of SARS-CoV-2 S1 protein and the human ACE-2 receptor. This method was compared to the current state of the art plaque reduction neutralization test (PRNT) and a high correlation between the two methods was observed. Using a large cohort of blood samples from convalescent patients and controls the method displays very high sensitivity and specificity (99,8% and 99.99%, respectively). Neutralizing antibody titers of mRNA-1273 and BNT162b2-vaccinated persons can also be quantified with this method as well. This fully automated method provides the possibility to determine anti-SARS-CoV-2 neutralizing antibody concentrations in just 2 h.", "doi": "10.1016/j.jim.2022.113258", "pmid": "35304119", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0022-1759(22)00045-X"}, {"db": "pmc", "key": "PMC8923036"}], "notes": [], "created": "2022-04-04T07:19:52.436Z", "modified": "2022-04-04T07:19:52.472Z"}, {"entity": "publication", "iuid": "93c162d21f494e0a9e1a42eda9e6db43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/93c162d21f494e0a9e1a42eda9e6db43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/93c162d21f494e0a9e1a42eda9e6db43"}}, "title": "Structure-based drug repurposing: Traditional and advanced AI/ML-aided methods.", "authors": [{"family": "Choudhury", "given": "Chinmayee", "initials": "C"}, {"family": "Arul Murugan", "given": "N", "initials": "N"}, {"family": "Deva Priyakumar", "given": "U", "initials": "U"}], "type": "journal article", "published": "2022-03-14", "journal": {"title": "Drug Discov Today", "issn": "1878-5832", "issn-l": null}, "abstract": "The current global health emergency in the form of the Coronavirus 2019 (COVID-19) pandemic has highlighted the need for fast, accurate, and efficient drug discovery pipelines. Traditional drug discovery projects relying on in vitro high-throughput screening (HTS) involve large investments and sophisticated experimental set-ups, affordable only to big biopharmaceutical companies. In this scenario, application of efficient state-of-the-art computational methods and modern artificial intelligence (AI)-based algorithms for rapid screening of repurposable chemical space [approved drugs and natural products (NPs) with proven pharmacokinetic profiles] to identify the initial leads is a powerful option to save resources and time. Structure-based drug repurposing is a popular in silico repurposing approach. In this review, we discuss traditional and modern AI-based computational methods and tools applied at various stages for structure-based drug discovery (SBDD) pipelines. Additionally, we highlight the role of generative models in generating molecules with scaffolds from repurposable chemical space.", "doi": "10.1016/j.drudis.2022.03.006", "pmid": "35301148", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1359-6446(22)00112-X"}, {"db": "pmc", "key": "PMC8920090"}], "notes": [], "created": "2022-04-04T07:21:32.874Z", "modified": "2022-04-04T07:21:32.888Z"}, {"entity": "publication", "iuid": "0fc4043c324c449ca2012a1bbf06b59d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0fc4043c324c449ca2012a1bbf06b59d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0fc4043c324c449ca2012a1bbf06b59d"}}, "title": "Inhibition of the main protease of SARS-CoV-2 (Mpro) by repurposing/designing drug-like substances and utilizing nature's toolbox of bioactive compounds.", "authors": [{"family": "Antonopoulou", "given": "Io", "initials": "I"}, {"family": "Sapountzaki", "given": "Eleftheria", "initials": "E"}, {"family": "Rova", "given": "Ulrika", "initials": "U"}, {"family": "Christakopoulos", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2022-03-14", "journal": {"title": "Comput Struct Biotechnol J", "issn": "2001-0370", "volume": "20", "pages": "1306-1344", "issn-l": "2001-0370"}, "abstract": "The emergence of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has resulted in a long pandemic, with numerous cases and victims worldwide and enormous consequences on social and economic life. Although vaccinations have proceeded and provide a valuable shield against the virus, the approved drugs are limited and it is crucial that further ways to combat infection are developed, that can also act against potential mutations. The main protease (Mpro) of the virus is an appealing target for the development of inhibitors, due to its importance in the viral life cycle and its high conservation among different coronaviruses. Several compounds have shown inhibitory potential against Mpro, both in silico and in vitro, with few of them also having entered clinical trials. These candidates include: known drugs that have been repurposed, molecules specifically designed based on the natural substrate of the protease or on structural moieties that have shown high binding affinity to the protease active site, as well as naturally derived compounds, either isolated or in plant extracts. The aim of this work is to collectively present the results of research regarding Mpro inhibitors to date, focusing on the function of the compounds founded by in silico simulations and further explored by in vitro and in vivo assays. Creating an extended portfolio of promising compounds that may block viral replication by inhibiting Mpro and by understanding involved structure-activity relationships, could provide a basis for the development of effective solutions against SARS-CoV-2 and future related outbreaks.", "doi": "10.1016/j.csbj.2022.03.009", "pmid": "35308802", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2001-0370(22)00084-8"}, {"db": "pmc", "key": "PMC8920478"}], "notes": [], "created": "2022-03-23T06:14:41.590Z", "modified": "2022-04-04T07:11:33.427Z"}, {"entity": "publication", "iuid": "b5e110e4d36741ee9862c91028d624df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5e110e4d36741ee9862c91028d624df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5e110e4d36741ee9862c91028d624df"}}, "title": "Natural SARS-CoV-2 Infection Affects Neutralizing Activity in Saliva of Vaccinees.", "authors": [{"family": "Garziano", "given": "Micaela", "initials": "M"}, {"family": "Utyro", "given": "Olga", "initials": "O"}, {"family": "Poliseno", "given": "Mariacristina", "initials": "M"}, {"family": "Santantonio", "given": "Teresa Antonia", "initials": "TA"}, {"family": "Saulle", "given": "Irma", "initials": "I"}, {"family": "Strizzi", "given": "Sergio", "initials": "S"}, {"family": "Lo Caputo", "given": "Sergio", "initials": "S"}, {"family": "Clerici", "given": "Mario", "initials": "M"}, {"family": "Introini", "given": "Andrea", "initials": "A"}, {"family": "Biasin", "given": "Mara", "initials": "M"}], "type": "journal article", "published": "2022-03-11", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "13", "pages": "820250", "issn-l": "1664-3224"}, "abstract": "SARS-CoV-2 transmission mainly occurs through exposure of the upper airway mucosa to infected secretions such as saliva, which are excreted by an infected person. Thus, oral mucosal immunity plays a central role in the prevention of and early defense against SARS-CoV-2 infection. Although virus-specific antibody response has been extensively investigated in blood samples of SARS-CoV-2-infected patients and vaccinees, local humoral immunity in the oral cavity and its relationship to systemic antibody levels needs to be further addressed.\n\nWe fine-tuned a virus neutralization assay (vNTA) to measure the neutralizing activity (NA) of plasma and saliva samples from 20 SARS-CoV-2-infected (SI), 40 SARS-CoV-2-vaccinated (SV), and 28 SARS-CoV-2-vaccinated subjects with a history of infection (SIV) using the \"wild type\" SARS-CoV-2 lineage B.1 (EU) and the Delta (B.1.617.2) strains. To validate the vNTA results, the presence of neutralizing antibodies (NAbs) to the spike receptor binding domain (RBD) was evaluated with an ELISA assay.\n\nNA to SARS-CoV-2 lineage B.1 (EU) was present in plasma samples from all the tested subjects, with higher titers in SIV compared to both SI and SV. Conversely, NA was detected in saliva samples from 10.3% SV, 45% SI, and 92.6% SIV, with significantly lower titers in SV compared to both SI and SIV. The detection of NAbs in saliva reflected its reduced NA in SV.\n\nThe difference in NA of plasma vs. saliva was confirmed in a vNTA where the SARS-CoV-2 B.1 and Delta strains were tested head-to-head, which also revealed a reduced NA of both specimens compared to the B.1 variant.\n\nThe administration of SARS-CoV-2 vaccines was associated with limited virus NA in the oral cavity, as measured in saliva and in comparison to plasma. This difference was more evident in vaccinees without a history of SARS-CoV-2 infection, possibly highlighting the importance of local exposure at the site of virus acquisition to effectively prevent the infection and block its spread. Nevertheless, the presence of immune escape mutations as possibly represented by the SARS-CoV-2 Delta variant negatively affects both local and systemic efficacy of NA associated with vaccination.", "doi": "10.3389/fimmu.2022.820250", "pmid": "35359971", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8962193"}], "notes": [], "created": "2022-04-04T06:33:12.170Z", "modified": "2022-04-04T06:33:12.183Z"}, {"entity": "publication", "iuid": "1baee0c983ad45ff89c7121e577fd912", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1baee0c983ad45ff89c7121e577fd912.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1baee0c983ad45ff89c7121e577fd912"}}, "title": "Experimental Model of Pulmonary Inflammation Induced by SARS-CoV-2 Spike Protein and Endotoxin.", "authors": [{"family": "Puthia", "given": "Manoj", "initials": "M", "orcid": "0000-0001-6048-7234", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9570effdcf284ffdb350c082fc830dac.json"}}, {"family": "Tanner", "given": "Lloyd", "initials": "L"}, {"family": "Petruk", "given": "Ganna", "initials": "G"}, {"family": "Schmidtchen", "given": "Artur", "initials": "A", "orcid": "0000-0001-9209-3141", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/426e00c7c8314ea195f2670af469e19a.json"}}], "type": "journal article", "published": "2022-03-11", "journal": {"title": "ACS Pharmacol. Transl. Sci.", "issn": "2575-9108", "volume": "5", "issue": "3", "pages": "141-148", "issn-l": null}, "abstract": "COVID-19 is characterized by a dysregulated and excessive inflammatory response and, in severe cases, acute respiratory distress syndrome. We have recently demonstrated a previously unknown high-affinity interaction between the SARS-CoV-2 spike (S) protein and bacterial lipopolysaccharide (LPS), leading to the boosting of inflammation. Here we present a mouse inflammation model employing the coadministration of aerosolized S protein together with LPS to the lungs. Using NF-\u03baB-RE-Luc reporter and C57BL/6 mice followed by combinations of bioimaging, cytokine, chemokine, fluorescence-activated cell sorting, and histochemistry analyses, we show that the model yields severe pulmonary inflammation and a cytokine profile similar to that observed in COVID-19. Therefore, the model offers utility for analyses of the pathophysiological features of COVID-19 and the development of new treatments.", "doi": "10.1021/acsptsci.1c00219", "pmid": "35774232", "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9239546"}], "notes": [], "created": "2022-08-17T13:13:35.479Z", "modified": "2022-08-17T13:13:35.592Z"}, {"entity": "publication", "iuid": "5e5f888e68164ea493149edbf81b7f7d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e5f888e68164ea493149edbf81b7f7d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e5f888e68164ea493149edbf81b7f7d"}}, "title": "Efficacy of Adaptogens in Patients with Long COVID-19: A Randomized, Quadruple-Blind, Placebo-Controlled Trial.", "authors": [{"family": "Karosanidze", "given": "Irina", "initials": "I"}, {"family": "Kiladze", "given": "Ushangi", "initials": "U"}, {"family": "Kirtadze", "given": "Nino", "initials": "N"}, {"family": "Giorgadze", "given": "Mikhail", "initials": "M"}, {"family": "Amashukeli", "given": "Nana", "initials": "N"}, {"family": "Parulava", "given": "Nino", "initials": "N"}, {"family": "Iluridze", "given": "Neli", "initials": "N"}, {"family": "Kikabidze", "given": "Nana", "initials": "N"}, {"family": "Gudavadze", "given": "Nana", "initials": "N"}, {"family": "Gelashvili", "given": "Lali", "initials": "L"}, {"family": "Koberidze", "given": "Vazha", "initials": "V"}, {"family": "Gigashvili", "given": "Eka", "initials": "E"}, {"family": "Jajanidze", "given": "Natela", "initials": "N"}, {"family": "Latsabidze", "given": "Naira", "initials": "N"}, {"family": "Mamageishvili", "given": "Nato", "initials": "N"}, {"family": "Shengelia", "given": "Ramaz", "initials": "R"}, {"family": "Hovhannisyan", "given": "Areg", "initials": "A"}, {"family": "Panossian", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8467-4525", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86a40ce1842b4c289c7f09c955ad4325.json"}}], "type": "journal article", "published": "2022-03-11", "journal": {"title": "Pharmaceuticals (Basel)", "issn": "1424-8247", "volume": "15", "issue": "3", "issn-l": null}, "abstract": "Currently, no effective treatment of comorbid complications or COVID-19 long-haulers during convalescence is known. This randomized, quadruple-blind, placebo-controlled trial aimed to assess the efficacy of adaptogens on the recovery of patients with Long COVID symptoms. One hundred patients with confirmed positive SARS-CoV-2 test, discharged from COVID Hotel isolation, Intensive Care Unit (ICU), or Online Clinics, and who experienced at least three of nine Long COVID symptoms (fatigue, headache, respiratory insufficiency, cognitive performance, mood disorders, loss of smell, taste, and hair, sweatiness, cough, pain in joints, muscles, and chest) in the 30 days before randomization were included in the study of the efficacy of Chisan\u00ae/ADAPT-232 (a fixed combination of adaptogens Rhodiola, Eleutherococcus, and Schisandra) supplementation for two weeks. Chisan\u00ae decreased the duration of fatigue and pain for one and two days, respectively, in 50% of patients. The number of patients with lack of fatigue and pain symptoms was significantly less in the Chisan\u00ae treatment group than in the placebo group on Days 9 (39% vs. 57%, pain relief, p = 0.0019) and 11 (28% vs. 43%, relief of fatigue, * p = 0.0157). Significant relief of severity of all Long COVID symptoms over the time of treatment and the follow-up period was observed in both groups of patients, notably decreasing the level of anxiety and depression from mild and moderate to normal, as well as increasing cognitive performance in patients in the d2 test for attention and increasing their physical activity and workout (daily walk time). However, the significant difference between placebo and Chisan\u00ae treatment was observed only with a workout (daily walk time) and relieving respiratory insufficiency (cough). A clinical assessment of blood markers of the inflammatory response (C-reactive protein) and blood coagulation (D-dimer) did not reveal any significant difference over time between treatment groups except significantly lower IL-6 in the Chisan\u00ae treatment group. Furthermore, a significant difference between the placebo and Chisan\u00ae treatment was observed for creatinine: Chisan\u00ae significantly decreased blood creatinine compared to the placebo, suggesting prevention of renal failure progression in Long COVID. In this study, we, for the first time, demonstrate that adaptogens can increase physical performance in Long COVID and reduce the duration of fatigue and chronic pain. It also suggests that Chisan\u00ae/ADAPT-232 might be useful for preventing the progression of renal failure associated with increasing creatinine.", "doi": "10.3390/ph15030345", "pmid": "35337143", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "ph15030345"}, {"db": "pmc", "key": "PMC8953947"}], "notes": [], "created": "2022-04-04T06:51:25.997Z", "modified": "2022-04-04T06:51:26.077Z"}, {"entity": "publication", "iuid": "2e67f1e6d6c64aa2a85ac23ba45946a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e67f1e6d6c64aa2a85ac23ba45946a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e67f1e6d6c64aa2a85ac23ba45946a1"}}, "title": "How the Innate Immune System of the Blood Contributes to Systemic Pathology in COVID-19-Induced ARDS and Provides Potential Targets for Treatment.", "authors": [{"family": "Nilsson", "given": "Bo", "initials": "B"}, {"family": "Persson", "given": "Barbro", "initials": "B"}, {"family": "Eriksson", "given": "Oskar", "initials": "O"}, {"family": "Fromell", "given": "Karin", "initials": "K"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Huber-Lang", "given": "Markus", "initials": "M"}, {"family": "Ekdahl", "given": "Kristina N", "initials": "KN"}], "type": "journal article", "published": "2022-03-08", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "13", "issue": null, "pages": "840137"}, "abstract": "Most SARS-CoV-2 infected patients experience influenza-like symptoms of low or moderate severity. But, already in 2020 early during the pandemic it became obvious that many patients had a high incidence of thrombotic complications, which prompted treatment with high doses of low-molecular-weight heparin (LMWH; typically 150-300IU/kg) to prevent thrombosis. In some patients, the disease aggravated after approximately 10 days and turned into a full-blown acute respiratory distress syndrome (ARDS)-like pulmonary inflammation with endothelialitis, thrombosis and vascular angiogenesis, which often lead to intensive care treatment with ventilator support. This stage of the disease is characterized by dysregulation of cytokines and chemokines, in particular with high IL-6 levels, and also by reduced oxygen saturation, high risk of thrombosis, and signs of severe pulmonary damage with ground glass opacities. The direct link between SARS-CoV-2 and the COVID-19-associated lung injury is not clear. Indirect evidence speaks in favor of a thromboinflammatory reaction, which may be initiated by the virus itself and by infected damaged and/or apoptotic cells. We and others have demonstrated that life-threatening COVID-19 ARDS is associated with a strong activation of the intravascular innate immune system (IIIS). In support of this notion is that activation of the complement and kallikrein/kinin (KK) systems predict survival, the necessity for usage of mechanical ventilation, acute kidney injury and, in the case of MBL, also coagulation system activation with thromboembolism. The general properties of the IIIS can easily be translated into mechanisms of COVID-19 pathophysiology. The prognostic value of complement and KKsystem biomarkers demonstrate that pharmaceuticals, which are licensed or have passed the phase I trial stage are promising candidate drugs for treatment of COVID-19. Examples of such compounds include complement inhibitors AMY-101 and eculizumab (targeting C3 and C5, respectively) as well as kallikrein inhibitors ecallantide and lanadelumab and the bradykinin receptor (BKR) 2 antagonist icatibant. In this conceptual review we discuss the activation, crosstalk and the therapeutic options that are available for regulation of the IIIS.", "doi": "10.3389/fimmu.2022.840137", "pmid": "35350780", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8957861"}], "notes": [], "created": "2022-04-04T06:37:36.306Z", "modified": "2022-08-19T12:35:35.442Z"}, {"entity": "publication", "iuid": "f1049c44123e48d9bf373c9e55a0808c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1049c44123e48d9bf373c9e55a0808c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1049c44123e48d9bf373c9e55a0808c"}}, "title": "Alphacoronavirus in a Daubenton's Myotis Bat (Myotis daubentonii) in Sweden.", "authors": [{"family": "Lwande", "given": "Olivia Wesula", "initials": "OW"}, {"family": "Thalin", "given": "Therese", "initials": "T"}, {"family": "de Jong", "given": "Johnny", "initials": "J"}, {"family": "Sj\u00f6din", "given": "Andreas", "initials": "A", "orcid": "0000-0001-5350-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea9e0de5833a4fb8b1a0039f80d75497.json"}}, {"family": "N\u00e4slund", "given": "Jonas", "initials": "J", "orcid": "0000-0002-4980-913X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6df0e6caa2340bb83bdf02c8fda67d1.json"}}, {"family": "Evander", "given": "Magnus", "initials": "M", "orcid": "0000-0001-6034-4807", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a6d141b52d747d2a63e32e1b2a2ff3d.json"}}, {"family": "Ecke", "given": "Frauke", "initials": "F", "orcid": "0000-0003-4208-345X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2e4af95902b4c45aeb2b0290fe70ebb.json"}}], "type": "journal article", "published": "2022-03-08", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "3", "issn-l": "1999-4915"}, "abstract": "The ongoing COVID-19 pandemic has stimulated a search for reservoirs and species potentially involved in back and forth transmission. Studies have postulated bats as one of the key reservoirs of coronaviruses (CoVs), and different CoVs have been detected in bats. So far, CoVs have not been found in bats in Sweden and we therefore tested whether they carry CoVs. In summer 2020, we sampled a total of 77 adult bats comprising 74 Myotis daubentonii, 2 Pipistrellus pygmaeus, and 1 M. mystacinus bats in southern Sweden. Blood, saliva and feces were sampled, processed and subjected to a virus next-generation sequencing target enrichment protocol. An Alphacoronavirus was detected and sequenced from feces of a M. daubentonii adult female bat. Phylogenetic analysis of the almost complete virus genome revealed a close relationship with Finnish and Danish strains. This was the first finding of a CoV in bats in Sweden, and bats may play a role in the transmission cycle of CoVs in Sweden. Focused and targeted surveillance of CoVs in bats is warranted, with consideration of potential conflicts between public health and nature conservation required as many bat species in Europe are threatened and protected.", "doi": "10.3390/v14030556", "pmid": "35336963", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "v14030556"}, {"db": "pmc", "key": "PMC8953627"}], "notes": [], "created": "2022-04-04T06:51:48.847Z", "modified": "2022-04-04T06:52:01.079Z"}, {"entity": "publication", "iuid": "9af12608a3ea4e4fbf5519d7c128dbe6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9af12608a3ea4e4fbf5519d7c128dbe6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9af12608a3ea4e4fbf5519d7c128dbe6"}}, "title": "The Impact of COVID-19 Confinement on Tinnitus and Hearing Loss in Older Adults: Data From the LOST in Lombardia Study.", "authors": [{"family": "Jarach", "given": "Carlotta Micaela", "initials": "CM"}, {"family": "Lugo", "given": "Alessandra", "initials": "A"}, {"family": "Stival", "given": "Chiara", "initials": "C"}, {"family": "Bosetti", "given": "Cristina", "initials": "C"}, {"family": "Amerio", "given": "Andrea", "initials": "A"}, {"family": "Cavalieri d'Oro", "given": "Luca", "initials": "L"}, {"family": "Iacoviello", "given": "Licia", "initials": "L"}, {"family": "Odone", "given": "Anna", "initials": "A"}, {"family": "Stuckler", "given": "David", "initials": "D"}, {"family": "Zucchi", "given": "Alberto", "initials": "A"}, {"family": "van den Brandt", "given": "Piet", "initials": "P"}, {"family": "Garavello", "given": "Werner", "initials": "W"}, {"family": "Cederroth", "given": "Christopher R", "initials": "CR"}, {"family": "Schlee", "given": "Winfried", "initials": "W"}, {"family": "Gallus", "given": "Silvano", "initials": "S"}, {"family": "LOST in Lombardia Study Investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2022-03-07", "journal": {"title": "Front Neurol", "issn": "1664-2295", "volume": "13", "pages": "838291", "issn-l": null}, "abstract": "Although a direct relationship between tinnitus or hearing difficulties and COVID-19 has been suggested, current literature provides inconsistent results, and no research has been undertaken in older adults.\n\nIn November 2020, we conducted the LOST in Lombardia survey, a telephone-based cross-sectional study on a sample of 4,400 individuals representative of the general population aged \u226565 years from Lombardy region, Northern Italy. Individuals with diagnosed tinnitus and/or hearing loss were asked whether their conditions had improved or deteriorated in 2020 compared to 2019.\n\nOverall, 8.1% of older adults reported a diagnosis of tinnitus and 10.5% of hearing loss. In 2020 compared to 2019, among individuals with tinnitus, those with increasing severity (5.0%) were similar to those decreasing it (5.3%). Among individuals with hearing loss, more people reported an increase (13.6%) than a decrease (3.2%) in their disease severity. No individual with a diagnosis in 2020 of tinnitus (n = 6) or hearing loss (n = 13) had COVID-19. The incidence of tinnitus was lower in 2020 (rate: 14.8 per 10,000 person-years) than in previous years (rate in 1990-2019: 36.0 per 10,000 person-years; p = 0.026). There was no change in the incidence of hearing loss (p = 0.134).\n\nIn this large representative sample of older adults, on average neither COVID-19 confinement nor SARS-CoV-2 infection appeared to increase the severity or incidence of tinnitus. The increased severity of hearing difficulties may totally or partially be explained by physiologic deterioration of the condition, or by a misperception due to the use of face-masks.", "doi": "10.3389/fneur.2022.838291", "pmid": "35330807", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8940241"}], "notes": [], "created": "2022-04-04T06:59:19.890Z", "modified": "2022-04-04T06:59:19.929Z"}, {"entity": "publication", "iuid": "32408591666645588f30bb91a9bc5573", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/32408591666645588f30bb91a9bc5573.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/32408591666645588f30bb91a9bc5573"}}, "title": "Reduced immunogenicity of a third COVID-19 vaccination among recipients of allogeneic haematopoietic stem cell transplantation.", "authors": [{"family": "Einarsdottir", "given": "Sigrun", "initials": "S"}, {"family": "Martner", "given": "Anna", "initials": "A"}, {"family": "Nicklasson", "given": "Malin", "initials": "M"}, {"family": "Wiktorin", "given": "Hanna Grauers", "initials": "HG"}, {"family": "Arabpour", "given": "Mohammad", "initials": "M"}, {"family": "T\u00f6rnell", "given": "Andreas", "initials": "A"}, {"family": "Vaht", "given": "Krista", "initials": "K"}, {"family": "Waldenstr\u00f6m", "given": "Jesper", "initials": "J"}, {"family": "Ringlander", "given": "Johan", "initials": "J"}, {"family": "Bergstr\u00f6m", "given": "Tomas", "initials": "T"}, {"family": "Brune", "given": "Mats", "initials": "M"}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Lagging", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2022-03-03", "journal": {"title": "Haematologica", "issn": "1592-8721", "issn-l": null}, "abstract": "Not available.", "doi": "10.3324/haematol.2021.280494", "pmid": "35236057", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2022-03-04T06:18:44.595Z", "modified": "2022-03-04T06:19:05.660Z"}, {"entity": "publication", "iuid": "d160f1a1ac56447bbc94ec7cb9d00da0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d160f1a1ac56447bbc94ec7cb9d00da0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d160f1a1ac56447bbc94ec7cb9d00da0"}}, "title": "Human serum from SARS-CoV-2-vaccinated and COVID-19 patients shows reduced binding to the RBD of SARS-CoV-2 Omicron variant.", "authors": [{"family": "Schubert", "given": "Maren", "initials": "M", "orcid": "0000-0002-7041-9056", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/896d0278735a4c96b326666b36fd47c3.json"}}, {"family": "Bertoglio", "given": "Federico", "initials": "F", "orcid": "0000-0001-6477-1785", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f9424e832a44ce9b8482a128fbc91ae.json"}}, {"family": "Steinke", "given": "Stephan", "initials": "S", "orcid": "0000-0001-8559-954X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68ea5cf01e194e4383b0844d01e65f08.json"}}, {"family": "Heine", "given": "Philip Alexander", "initials": "PA", "orcid": "0000-0001-9643-6973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/084dfc2bbcb04ca98100923beb096ecb.json"}}, {"family": "Ynga-Durand", "given": "Mario Alberto", "initials": "MA", "orcid": "0000-0002-8586-3993", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bfb80f86d8c4fdabad58bedaea710f6.json"}}, {"family": "Maass", "given": "Henrike", "initials": "H"}, {"family": "Sammartino", "given": "Jos\u00e8 Camilla", "initials": "JC"}, {"family": "Cassaniti", "given": "Irene", "initials": "I"}, {"family": "Zuo", "given": "Fanglei", "initials": "F", "orcid": "0000-0002-4545-1265", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11312f803b4f49d6be77684a634b0caf.json"}}, {"family": "Du", "given": "Likun", "initials": "L", "orcid": "0000-0002-8448-2187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c03c88bf35744aa69ee3569394758ba6.json"}}, {"family": "Korn", "given": "Janin", "initials": "J"}, {"family": "Milo\u0161evi\u0107", "given": "Marko", "initials": "M"}, {"family": "Wenzel", "given": "Esther Veronika", "initials": "EV", "orcid": "0000-0002-6931-5612", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73e24d78e79d4952a3c188b0e8166bd6.json"}}, {"family": "Krstanovi\u0107", "given": "Fran", "initials": "F"}, {"family": "Polten", "given": "Saskia", "initials": "S"}, {"family": "Pribani\u0107-Mate\u0161i\u0107", "given": "Marina", "initials": "M"}, {"family": "Brizi\u0107", "given": "Ilija", "initials": "I"}, {"family": "Baldanti", "given": "Fausto", "initials": "F", "orcid": "0000-0002-3358-8969", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ad31c69d57a43b69e2a4d609d59ab0c.json"}}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "D\u00fcbel", "given": "Stefan", "initials": "S", "orcid": "0000-0001-8811-7390", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fdc38fd876784e20958f659bb25bdde4.json"}}, {"family": "\u0160usti\u0107", "given": "Alan", "initials": "A"}, {"family": "Marcotte", "given": "Harold", "initials": "H", "orcid": "0000-0002-7168-349X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e05b7b044674cc08cd2269ccf8c076e.json"}}, {"family": "Strengert", "given": "Monika", "initials": "M"}, {"family": "Proti\u0107", "given": "Alen", "initials": "A", "orcid": "0000-0002-6573-852X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41668eb51fb64576b6a864e9e7432f1f.json"}}, {"family": "Piralla", "given": "Antonio", "initials": "A"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q", "orcid": "0000-0003-1990-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94a32366862b470eba3a15521b9be290.json"}}, {"family": "\u010ci\u010din-\u0160ain", "given": "Luka", "initials": "L", "orcid": "0000-0003-3978-778X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42fed6a06cbb42b99166b05c15466483.json"}}, {"family": "Hust", "given": "Michael", "initials": "M", "orcid": "0000-0003-3418-6045", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0587ca1111f84a61aaf8917a123d49c1.json"}}], "type": "journal article", "published": "2022-03-03", "journal": {"title": "BMC Med", "issn": "1741-7015", "issn-l": null, "volume": "20", "issue": "1", "pages": "102"}, "abstract": "The COVID-19 pandemic is caused by the betacoronavirus SARS-CoV-2. In November 2021, the Omicron variant was discovered and immediately classified as a variant of concern (VOC), since it shows substantially more mutations in the spike protein than any previous variant, especially in the receptor-binding domain (RBD). We analyzed the binding of the Omicron RBD to the human angiotensin-converting enzyme-2 receptor (ACE2) and the ability of human sera from COVID-19 patients or vaccinees in comparison to Wuhan, Beta, or Delta RBD variants.\r\n\r\nAll RBDs were produced in insect cells. RBD binding to ACE2 was analyzed by ELISA and microscale thermophoresis (MST). Similarly, sera from 27 COVID-19 patients, 81 vaccinated individuals, and 34 booster recipients were titrated by ELISA on RBDs from the original Wuhan strain, Beta, Delta, and Omicron VOCs. In addition, the neutralization efficacy of authentic SARS-CoV-2 wild type (D614G), Delta, and Omicron by sera from 2\u00d7 or 3\u00d7 BNT162b2-vaccinated persons was analyzed.\r\n\r\nSurprisingly, the Omicron RBD showed a somewhat weaker binding to ACE2 compared to Beta and Delta, arguing that improved ACE2 binding is not a likely driver of Omicron evolution. Serum antibody titers were significantly lower against Omicron RBD compared to the original Wuhan strain. A 2.6\u00d7 reduction in Omicron RBD binding was observed for serum of 2\u00d7 BNT162b2-vaccinated persons. Neutralization of Omicron SARS-CoV-2 was completely diminished in our setup.\r\n\r\nThese results indicate an immune escape focused on neutralizing antibodies. Nevertheless, a boost vaccination increased the level of anti-RBD antibodies against Omicron, and neutralization of authentic Omicron SARS-CoV-2 was at least partially restored. This study adds evidence that current vaccination protocols may be less efficient against the Omicron variant.", "doi": "10.1186/s12916-022-02312-5", "pmid": "35236358", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Category: Omicron VoC": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12916-022-02312-5"}], "notes": [], "created": "2022-01-04T15:39:53.792Z", "modified": "2022-03-04T06:16:50.719Z"}, {"entity": "publication", "iuid": "7703dbb65d114688adfed1a169a34cc0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7703dbb65d114688adfed1a169a34cc0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7703dbb65d114688adfed1a169a34cc0"}}, "title": "High seroconversion rate after vaccination with mRNA BNT162b2 vaccine against SARS-CoV-2 among people with HIV - but HIV viremia matters?", "authors": [{"family": "Xu", "given": "Xinling", "initials": "X"}, {"family": "Vesterbacka", "given": "Jan", "initials": "J"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "COVAXID Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-03-01", "journal": {"title": "AIDS", "issn": "1473-5571", "volume": "36", "issue": "3", "pages": "479-481", "issn-l": null}, "abstract": "Our clinical trial of SARS-COV-2 mRNA vaccine in 90 HIV-infected persons on antiviral treatment demonstrated high seroconversion rate and high levels of spike IgG antibodies after two doses of vaccine. The vaccine was well tolerated and not associated with HIV RNA blips. However, the levels of spike IgG antibodies were lower in HIV patients than in healthy controls, especially among those with HIV RNA more than 50 copies/ml at baseline.", "doi": "10.1097/QAD.0000000000003135", "pmid": "35084386", "labels": {"Category: Health": null, "Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "00002030-202203010-00018"}], "notes": [], "created": "2022-01-31T11:46:52.414Z", "modified": "2022-01-31T11:47:42.552Z"}, {"entity": "publication", "iuid": "e2868a3088b7488ba58a50adb64fc094", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2868a3088b7488ba58a50adb64fc094.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2868a3088b7488ba58a50adb64fc094"}}, "title": "Coping with COVID: risk and resilience factors for mental health in a German representative panel study.", "authors": [{"family": "Riepenhausen", "given": "Antje", "initials": "A", "orcid": "0000-0001-8749-5349", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b96a93d2ea914a52bbcad45210d9dec7.json"}}, {"family": "Veer", "given": "Ilya M", "initials": "IM"}, {"family": "Wackerhagen", "given": "Carolin", "initials": "C"}, {"family": "Reppmann", "given": "Zala C", "initials": "ZC"}, {"family": "K\u00f6ber", "given": "G\u00f6ran", "initials": "G"}, {"family": "Ayuso-Mateos", "given": "Jos\u00e9 Luis", "initials": "JL"}, {"family": "B\u00f6gemann", "given": "Sophie A", "initials": "SA"}, {"family": "Corrao", "given": "Giovanni", "initials": "G"}, {"family": "Felez-Nobrega", "given": "Mireia", "initials": "M"}, {"family": "Abad", "given": "Josep Maria Haro", "initials": "JMH"}, {"family": "Hermans", "given": "Erno", "initials": "E"}, {"family": "van Leeuwen", "given": "Judith", "initials": "J"}, {"family": "Lieb", "given": "Klaus", "initials": "K"}, {"family": "Lorant", "given": "Vincent", "initials": "V"}, {"family": "Mary-Krause", "given": "Murielle", "initials": "M"}, {"family": "Mediavilla", "given": "Roberto", "initials": "R"}, {"family": "Melchior", "given": "Maria", "initials": "M"}, {"family": "Mittendorfer-Rutz", "given": "Ellenor", "initials": "E"}, {"family": "Compagnoni", "given": "Matteo Monzio", "initials": "MM", "orcid": "0000-0002-2105-4572", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8008fcd69074d3fa6689539c259716f.json"}}, {"family": "Pan", "given": "Kuan-Yu", "initials": "KY"}, {"family": "Puhlmann", "given": "Lara", "initials": "L"}, {"family": "Roelofs", "given": "Karin", "initials": "K"}, {"family": "Sijbrandij", "given": "Marit", "initials": "M"}, {"family": "Smith", "given": "Pierre", "initials": "P"}, {"family": "T\u00fcscher", "given": "Oliver", "initials": "O"}, {"family": "Witteveen", "given": "Anke", "initials": "A"}, {"family": "Zerban", "given": "Matthias", "initials": "M"}, {"family": "Kalisch", "given": "Raffael", "initials": "R"}, {"family": "Kr\u00f6ger", "given": "Hannes", "initials": "H"}, {"family": "Walter", "given": "Henrik", "initials": "H"}], "type": "journal article", "published": "2022-03-01", "journal": {"title": "Psychol Med", "issn": "1469-8978", "pages": "1-11", "issn-l": "0033-2917"}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic might affect mental health. Data from population-representative panel surveys with multiple waves including pre-COVID data investigating risk and protective factors are still rare.\n\nIn a stratified random sample of the German household population (n = 6684), we conducted survey-weighted multiple linear regressions to determine the association of various psychological risk and protective factors assessed between 2015 and 2020 with changes in psychological distress [(PD; measured via Patient Health Questionnaire for Depression and Anxiety (PHQ-4)] from pre-pandemic (average of 2016 and 2019) to peri-pandemic (both 2020 and 2021) time points. Control analyses on PD change between two pre-pandemic time points (2016 and 2019) were conducted. Regularized regressions were computed to inform on which factors were statistically most influential in the multicollinear setting.\n\nPHQ-4 scores in 2020 (M = 2.45) and 2021 (M = 2.21) were elevated compared to 2019 (M = 1.79). Several risk factors (catastrophizing, neuroticism, and asking for instrumental support) and protective factors (perceived stress recovery, positive reappraisal, and optimism) were identified for the peri-pandemic outcomes. Control analyses revealed that in pre-pandemic times, neuroticism and optimism were predominantly related to PD changes. Regularized regression mostly confirmed the results and highlighted perceived stress recovery as most consistent influential protective factor across peri-pandemic outcomes.\n\nWe identified several psychological risk and protective factors related to PD outcomes during the COVID-19 pandemic. A comparison of pre-pandemic data stresses the relevance of longitudinal assessments to potentially reconcile contradictory findings. Implications and suggestions for targeted prevention and intervention programs during highly stressful times such as pandemics are discussed.", "doi": "10.1017/S0033291722000563", "pmid": "35301966", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0033291722000563"}, {"db": "pmc", "key": "PMC8943230"}], "notes": [], "created": "2022-04-04T07:20:45.813Z", "modified": "2022-04-04T07:20:45.905Z"}, {"entity": "publication", "iuid": "e9b0e6c430d542bdabbe5cdf483f005b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e9b0e6c430d542bdabbe5cdf483f005b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e9b0e6c430d542bdabbe5cdf483f005b"}}, "title": "Trends in alcohol consumption in relation to the COVID-19 pandemic: A cross-country analysis.", "authors": [{"family": "Plata", "given": "Alejandro", "initials": "A"}, {"family": "Motoki", "given": "Kosuke", "initials": "K"}, {"family": "Spence", "given": "Charles", "initials": "C"}, {"family": "Velasco", "given": "Carlos", "initials": "C"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Int J Gastron Food Sci", "issn": "1878-4518", "volume": "27", "pages": "100397", "issn-l": null}, "abstract": "During the first sequence of lockdowns implemented in many countries around the world in early 2020 as a result of the emerging COVID-19 pandemic, there was widespread concern amongst many health professionals regarding a predicted rise in alcohol consumption. However, studies have reported diverse findings, with some consumer groups exhibiting an increase and others a decrease in their alcohol purchase and consumption patterns. Although the long-lasting changes in alcohol consumption, if any, are still unknown, the current situation has effectively accelerated a number of pre-existing trends which will likely continue in the future. E-commerce is growing steadily, mainly because of the restrictions within the on-trade channel and concerns around catching COVID-19 amongst consumers, thus lifting traditional barriers to the adoption of digital channels. Premiumization has also grown significantly during the pandemic, especially in the spirits category, due, in part, to the fact that consumers have been increasingly trying to recreate bar and restaurant quality gastronomic experiences in the privacy of their own homes. The trend toward homemade experiences is multi-stakeholder as consumers, retailers, restaurateurs, bar owners, and brands all try to help facilitate at-home consumption experiences. Larger size purchases seem to reflect not only the stockpiling phenomena that occurred during the initial phases of the pandemic but also convenience for consumers (e.g., avoiding queues). Additionally, the growing home mixology movement has been observed to result in consumers buying larger amounts of alcohol in order to facilitate cocktail making experimentation at home. It is important to stress, though, that this review was specially focused on available data from the first three quarters of 2020, as an effort to identify and understand the initial impacts the COVID-19 was creating amongst alcohol consumers. It currently remains uncertain how these trends will evolve, and whether or not they will continue post COVID-19 (whenever that might be). Key similarities and differences across national markets are highlighted.", "doi": "10.1016/j.ijgfs.2021.100397", "pmid": "35003399", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1878-450X(21)00096-2"}, {"db": "pmc", "key": "PMC8717736"}], "notes": [], "created": "2022-01-13T21:10:53.363Z", "modified": "2022-01-13T21:10:53.401Z"}, {"entity": "publication", "iuid": "f15625c5aebb43d8951a7f1554f20ca1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f15625c5aebb43d8951a7f1554f20ca1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f15625c5aebb43d8951a7f1554f20ca1"}}, "title": "To vote, or not to vote? Electoral campaigns and the spread of COVID-19.", "authors": [{"family": "Cipullo", "given": "Davide", "initials": "D"}, {"family": "Le Moglie", "given": "Marco", "initials": "M"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Eur J Polit Econ", "issn": "0176-2680", "issn-l": null, "volume": "72", "issue": null, "pages": "102118"}, "abstract": "The possibility to run fair electoral campaigns is necessary for the legitimization of modern democracies through elections. Yet, during a pandemic, the risk that electoral campaigns would enhance the spread of the disease is substantive. In this paper, we estimate the causal impact of electoral campaigns on the spread of COVID-19. Exploiting plausibly exogenous variation in the schedule of local elections across Italy, we show that the electoral campaign preceding this latter led to a significant worsening of the epidemiological situation related to the disease. Our results strongly highlight the importance of undertaking stringent measures along the entire electoral process to minimize its epidemiological consequences.", "doi": "10.1016/j.ejpoleco.2021.102118", "pmid": "35317430", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0176-2680(21)00100-2"}, {"db": "pmc", "key": "PMC8931692"}], "notes": [], "created": "2022-04-04T07:10:49.639Z", "modified": "2022-11-22T05:39:27.695Z"}, {"entity": "publication", "iuid": "6dcc84c5565f4f16bc811dc31d81cb4b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6dcc84c5565f4f16bc811dc31d81cb4b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6dcc84c5565f4f16bc811dc31d81cb4b"}}, "title": "The impact of the COVID-19 pandemic on seafarers' mental health and chronic fatigue: Beneficial effects of onboard peer support, external support and Internet access.", "authors": [{"family": "Pauksztat", "given": "Birgit", "initials": "B"}, {"family": "Grech", "given": "Michelle R", "initials": "MR"}, {"family": "Kitada", "given": "Momoko", "initials": "M"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Mar Policy", "issn": "0308-597X", "volume": "137", "pages": "104942", "issn-l": null}, "abstract": "While commercial shipping remained vital for maintaining global supply chains during the COVID-19 pandemic, measures imposed to control the spread of infection have disrupted crew changes and impacted interactions with port personnel and among crew members on board. Initial reports indicate that this affected work and life on board, the length of seafarers' time on board as well as seafarers' employment and family concerns. However, the consequences for seafarers' well-being are not well understood. The purpose of this study was to examine the effects of the COVID-19 pandemic on seafarers' mental health and chronic fatigue, and to analyze the role of potential mitigating factors, notably onboard peer support, external support and Internet quality. Survey responses from 622 seafarers on international commercial vessels were analyzed using structural equation modeling. Findings suggested that the impact of the pandemic increased seafarers' fatigue and mental health problems. However, they also indicated ways of mitigating the negative impact of the pandemic and increasing resilience by enhancing support from fellow crew members on board, ensuring the availability of external support and providing fast and reliable Internet access.", "doi": "10.1016/j.marpol.2021.104942", "pmid": "35013636", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0308-597X(21)00553-4"}, {"db": "pmc", "key": "PMC8732879"}], "notes": [], "created": "2022-01-13T21:04:46.083Z", "modified": "2022-01-13T21:04:46.121Z"}, {"entity": "publication", "iuid": "29f0d487451f4f468291855f641a3944", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/29f0d487451f4f468291855f641a3944.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/29f0d487451f4f468291855f641a3944"}}, "title": "Risk of severe COVID-19 from the Delta and Omicron variants in relation to vaccination status, sex, age and comorbidities - surveillance results from southern Sweden, July 2021 to January 2022.", "authors": [{"family": "Kahn", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-5566-6350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42eda71f3775400599febc10a4e7359c.json"}}, {"family": "Bonander", "given": "Carl", "initials": "C", "orcid": "0000-0002-1189-9950", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/386ac82b1a4843828b503ec807c08206.json"}}, {"family": "Moghaddassi", "given": "Mahnaz", "initials": "M", "orcid": "0000-0002-0844-4736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a219bde5ba8a4f3f8655ada08d749885.json"}}, {"family": "Rasmussen", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1588-5473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c760e8d21ae441ba236f86e6185d392.json"}}, {"family": "Malmqvist", "given": "Ulf", "initials": "U"}, {"family": "Inghammar", "given": "Malin", "initials": "M", "orcid": "0000-0003-2995-1312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4ab710428614cccb2a537ecab31d0a0.json"}}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J", "orcid": "0000-0003-1883-2000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e88fdca336ae41c891f0a46e2481b67f.json"}}], "type": "journal article", "published": "2022-03-00", "journal": {"issn": "1560-7917", "volume": "27", "issue": "9", "title": "Euro Surveill", "issn-l": null}, "abstract": "We compared the risk of severe COVID-19 during two periods 2021 and 2022 when Delta and Omicron, respectively, were the dominating virus variants in Scania county, Sweden. We adjusted for differences in sex, age, comorbidities, prior infection and vaccination. Risk of severe disease from Omicron was markedly lower among vaccinated cases. It was also lower among the unvaccinated but remained high (> 5%) for older people and middle-aged men with two or more comorbidities. Efforts to increase vaccination uptake should continue.", "doi": "10.2807/1560-7917.ES.2022.27.9.2200121", "pmid": "35241215", "labels": {"Category: Health": null, "Category: Omicron VoC": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8895467"}], "notes": [], "created": "2022-03-04T12:16:55.501Z", "modified": "2023-01-13T13:29:15.838Z"}, {"entity": "publication", "iuid": "ced6307812f3447f90283e6d7a76ed1b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ced6307812f3447f90283e6d7a76ed1b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ced6307812f3447f90283e6d7a76ed1b"}}, "title": "Risk factors associated with an outbreak of COVID-19 in a meat processing plant in southern Germany, April to June 2020.", "authors": [{"family": "Finci", "given": "Iris", "initials": "I"}, {"family": "Siebenbaum", "given": "Remo", "initials": "R"}, {"family": "Richtzenhain", "given": "Josephin", "initials": "J"}, {"family": "Edwards", "given": "Angelika", "initials": "A"}, {"family": "Rau", "given": "Carina", "initials": "C"}, {"family": "Ehrhardt", "given": "Jonas", "initials": "J"}, {"family": "Koiou", "given": "Linda", "initials": "L"}, {"family": "Joggerst", "given": "Brigitte", "initials": "B"}, {"family": "Brockmann", "given": "Stefan O", "initials": "SO"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "27", "issue": "13", "issn-l": null}, "abstract": "Meat processing plants have been prominent hotspots for coronavirus disease (COVID-19) outbreaks around the world. We describe infection prevention measures and risk factors for infection spread at a meat processing plant in Germany with a COVID-19 outbreak from April to June 2020. We analysed a cohort of all employees and defined cases as employees with either a PCR or ELISA positive result. Of 1,270 employees, 453 (36%) had evidence of SARS-CoV-2 infection. The highest attack rates were observed in meat processing and slaughtering areas. Multivariable analysis revealed that being a subcontracted employee (adjusted risk ratio (aRR)): 1.43, 95% CI: 1.06-1.96), working in the meat cutting area (aRR: 2.44, 95% CI: 1.45-4.48), working in the slaughtering area (aRR: 2.35, 95% CI: 1.32-4.45) and being a veterinary inspector (aRR: 4.77, 95% CI: 1.16-23.68) increased infection risk. Sharing accommodation or transportation were not identified as risk factors for infection. Our results suggest that workplace was the main risk factor for infection spread. These results highlight the importance of implementing preventive measures targeting meat processing plants. Face masks, distancing, staggering breaks, increased hygiene and regular testing for SARS-CoV2 helped limit this outbreak, as the plant remained open throughout the outbreak.", "doi": "10.2807/1560-7917.ES.2022.27.13.2100354", "pmid": "35362409", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-04-04T06:26:04.791Z", "modified": "2022-04-04T06:32:06.397Z"}, {"entity": "publication", "iuid": "fbc972343a6d4cd5a996f6174fb380bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fbc972343a6d4cd5a996f6174fb380bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fbc972343a6d4cd5a996f6174fb380bf"}}, "title": "Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19.", "authors": [{"family": "Palmos", "given": "Alish B", "initials": "AB", "orcid": "0000-0001-5748-6652", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dcc29f88bdd44f679b0627ecde4b1369.json"}}, {"family": "Millischer", "given": "Vincent", "initials": "V", "orcid": "0000-0003-1919-9649", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fc3992e3cd045169e4b45e55e621071.json"}}, {"family": "Menon", "given": "David K", "initials": "DK", "orcid": "0000-0002-3228-9692", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a9033d3171140c696fcb18b9983ac2e.json"}}, {"family": "Nicholson", "given": "Timothy R", "initials": "TR", "orcid": "0000-0002-2350-2332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bd53b4c7f1a4b2a853fcefc53184111.json"}}, {"family": "Taams", "given": "Leonie S", "initials": "LS"}, {"family": "Michael", "given": "Benedict", "initials": "B", "orcid": "0000-0002-8693-8926", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d0bd491219e64319aef1794f6ae1761e.json"}}, {"family": "Sunderland", "given": "Geraint", "initials": "G", "orcid": "0000-0001-9040-5949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6fcce9323d74d719807117806217c46.json"}}, {"family": "Griffiths", "given": "Michael J", "initials": "MJ"}, {"family": "COVID Clinical Neuroscience Study Consortium", "given": "", "initials": ""}, {"family": "H\u00fcbel", "given": "Christopher", "initials": "C"}, {"family": "Breen", "given": "Gerome", "initials": "G"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "PLoS Genet", "issn": "1553-7404", "volume": "18", "issue": "3", "pages": "e1010042", "issn-l": null}, "abstract": "In November 2021, the COVID-19 pandemic death toll surpassed five million individuals. We applied Mendelian randomization including >3,000 blood proteins as exposures to identify potential biomarkers that may indicate risk for hospitalization or need for respiratory support or death due to COVID-19, respectively. After multiple testing correction, using genetic instruments and under the assumptions of Mendelian Randomization, our results were consistent with higher blood levels of five proteins GCNT4, CD207, RAB14, C1GALT1C1, and ABO being causally associated with an increased risk of hospitalization or respiratory support/death due to COVID-19 (ORs = 1.12-1.35). Higher levels of FAAH2 were solely associated with an increased risk of hospitalization (OR = 1.19). On the contrary, higher levels of SELL, SELE, and PECAM-1 decrease risk of hospitalization or need for respiratory support/death (ORs = 0.80-0.91). Higher levels of LCTL, SFTPD, KEL, and ATP2A3 were solely associated with a decreased risk of hospitalization (ORs = 0.86-0.93), whilst higher levels of ICAM-1 were solely associated with a decreased risk of respiratory support/death of COVID-19 (OR = 0.84). Our findings implicate blood group markers and binding proteins in both hospitalization and need for respiratory support/death. They, additionally, suggest that higher levels of endocannabinoid enzymes may increase the risk of hospitalization. Our research replicates findings of blood markers previously associated with COVID-19 and prioritises additional blood markers for risk prediction of severe forms of COVID-19. Furthermore, we pinpoint druggable targets potentially implicated in disease pathology.", "doi": "10.1371/journal.pgen.1010042", "pmid": "35239653", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "PGENETICS-D-21-01126"}], "notes": [], "created": "2022-03-04T06:17:49.932Z", "modified": "2022-03-04T06:18:03.322Z"}, {"entity": "publication", "iuid": "e4fb546c8a6f42708ca685bfc253704a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e4fb546c8a6f42708ca685bfc253704a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e4fb546c8a6f42708ca685bfc253704a"}}, "title": "Nowcasting (Short-Term Forecasting) of COVID-19 Hospitalizations Using Syndromic Healthcare Data, Sweden, 2020.", "authors": [{"family": "Spreco", "given": "Armin", "initials": "A"}, {"family": "J\u00f6ud", "given": "Anna", "initials": "A", "orcid": "0000-0001-7192-4911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e038a5ce2f5a47bd89e7c221651a3d24.json"}}, {"family": "Eriksson", "given": "Olle", "initials": "O"}, {"family": "Soltesz", "given": "Kristian", "initials": "K"}, {"family": "K\u00e4llstr\u00f6m", "given": "Reidar", "initials": "R"}, {"family": "Dahlstr\u00f6m", "given": "\u00d6rjan", "initials": "\u00d6"}, {"family": "Eriksson", "given": "Henrik", "initials": "H"}, {"family": "Ekberg", "given": "Joakim", "initials": "J"}, {"family": "Jonson", "given": "Carl-Oscar", "initials": "CO"}, {"family": "Fraenkel", "given": "Carl-Johan", "initials": "CJ"}, {"family": "Lundh", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Gerlee", "given": "Philip", "initials": "P", "orcid": "0000-0001-8503-0177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ba426c1ab741e781d2b9cd09a0b830.json"}}, {"family": "Gustafsson", "given": "Fredrik", "initials": "F"}, {"family": "Timpka", "given": "Toomas", "initials": "T"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Emerg Infect Dis", "issn": "1080-6059", "volume": "28", "issue": "3", "pages": "564-571", "issn-l": null}, "abstract": "We report on local nowcasting (short-term forecasting) of coronavirus disease (COVID-19) hospitalizations based on syndromic (symptom) data recorded in regular healthcare routines in \u00d6sterg\u00f6tland County (population \u2248465,000), Sweden, early in the pandemic, when broad laboratory testing was unavailable. Daily nowcasts were supplied to the local healthcare management based on analyses of the time lag between telenursing calls with the chief complaints (cough by adult or fever by adult) and COVID-19 hospitalization. The complaint cough by adult showed satisfactory performance (Pearson correlation coefficient r>0.80; mean absolute percentage error <20%) in nowcasting the incidence of daily COVID-19 hospitalizations 14 days in advance until the incidence decreased to <1.5/100,000 population, whereas the corresponding performance for fever by adult was unsatisfactory. Our results support local nowcasting of hospitalizations on the basis of symptom data recorded in routine healthcare during the initial stage of a pandemic.", "doi": "10.3201/eid2803.210267", "pmid": "35201737", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8888224"}], "notes": [], "created": "2023-01-13T13:40:49.234Z", "modified": "2023-06-19T14:58:56.435Z"}, {"entity": "publication", "iuid": "6dff0f71c8d54791be1886456cb3fcd2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6dff0f71c8d54791be1886456cb3fcd2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6dff0f71c8d54791be1886456cb3fcd2"}}, "title": "Inequitable impact of infection: social gradients in severe COVID-19 outcomes among all confirmed SARS-CoV-2 cases during the first pandemic wave in Sweden.", "authors": [{"family": "Gustafsson", "given": "Per E", "initials": "PE", "orcid": "0000-0002-3972-5362", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9ac282ae534432f9e8135a8070683bc.json"}}, {"family": "San Sebastian", "given": "Miguel", "initials": "M"}, {"family": "Fonseca-Rodriguez", "given": "Osvaldo", "initials": "O", "orcid": "0000-0002-0253-5928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52ff35d4b27c4150984ca0428976d442.json"}}, {"family": "Fors Connolly", "given": "Anne-Marie", "initials": "AM"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "J Epidemiol Community Health", "issn": "1470-2738", "issn-l": null, "volume": "76", "issue": "3", "pages": "261-267"}, "abstract": "The backdrop of the ubiquitous social inequalities has increasingly come into foreground in research on the COVID-19 pandemic, but the lack of high-quality population-based studies limits our understanding of the inequitable outcomes of the disease. The present study seeks to estimate social gradients in COVID-19 hospitalisations, intensive care admissions and death by education, income and country of birth, while taking into account disparities in comorbidities.\n\nWe used a register-based retrospective open cohort design enrolling all 74 659 confirmed SARS-CoV-2-positive cases aged >25 years in Sweden during the first wave of the pandemic (until 14 September 2020). Information was retrieved from multiple registers and linked by the unique Swedish personal identity number concerning COVID-19 case identification; COVID-19 hospitalisations, intensive care admissions and death; comorbidities as measured by the Charlson Comorbidity Index; and sociodemographic information. Social gradients were estimated by the Relative Index of Inequality (RII) using Cox regression.\n\nAdjusted analyses showed significant social gradients in COVID-19 hospitalisation, intensive care admission, across education, income and country of birth, which were unaffected by adjustment for comorbidities. Education and country of birth gradients were stronger for hospitalisation and intensive care admissions but small to non-existent for death. In contrast, income gradients were consistent across all three COVID-19 outcomes.\n\nSocial gradients in severe COVID-19 outcomes are widespread in Sweden, but appear to be unrelated to pre-existing health disparities. Inequitable outcomes of SARS-CoV-2 infection may therefore be at least partially avoidable and could rely on equitable management of confirmed COVID-19 cases.", "doi": "10.1136/jech-2021-216778", "pmid": "34526373", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8449839"}, {"db": "pii", "key": "jech-2021-216778"}], "notes": [], "created": "2021-09-20T16:49:45.287Z", "modified": "2023-01-13T13:54:20.184Z"}, {"entity": "publication", "iuid": "54b72a2f5d5d4388bf593a0fbc1bbaa5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54b72a2f5d5d4388bf593a0fbc1bbaa5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54b72a2f5d5d4388bf593a0fbc1bbaa5"}}, "title": "Impact of COVID-19 on adolescent travel behavior.", "authors": [{"family": "Liu", "given": "Jianrong", "initials": "J"}, {"family": "Cao", "given": "Qiongwen", "initials": "Q"}, {"family": "Pei", "given": "Mingyang", "initials": "M"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "J Transp Health", "issn": "2214-1405", "volume": "24", "pages": "101326", "issn-l": null}, "abstract": "The outbreak of COVID-19 has significantly impacted travel behavior. However, few studies have analyzed the impact of COVID-19 on adolescent travel behavior. This article analyzed the impact of COVID-19 on adolescent travel behavior using questionnaire survey data.\n\nThis paper first used confirmatory factor analysis (CFA) to explore the psychological factors related to the adolescents' perceptions about the severity of COVID-19. The study then established a logit model to study the effects of COVID-19 in different phases (before, during, and after the epidemic peak), demographic characteristics, and the role of psychological factors on their travel behavior.\n\nThe results show that the phase of COVID-19 did not significantly impact the adolescents' choice of short-distance travel. The frequency of outings per week, the number of exercise sessions per week, and willingness to travel by public transportation decreased significantly in the outbreak phase. Meanwhile, the perception of the severity of COVID-19 significantly impacted adolescent travel behavior.\n\nThis research demonstrates that COVID-19 has led adolescents to reduce their frequency of outings, and they try not to use public transportation. Adolescents appear to be traveling more cautiously in the outbreak phase and the post-epidemic phase.", "doi": "10.1016/j.jth.2021.101326", "pmid": "35013706", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2214-1405(21)00356-X"}, {"db": "pmc", "key": "PMC8730543"}], "notes": [], "created": "2022-01-13T21:04:28.715Z", "modified": "2022-01-13T21:04:28.749Z"}, {"entity": "publication", "iuid": "69ee238aa92f414db1e2f921762e76eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69ee238aa92f414db1e2f921762e76eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69ee238aa92f414db1e2f921762e76eb"}}, "title": "Ethics framework and recommendations to support capabilities of people with intellectual and developmental disabilities during pandemics.", "authors": [{"family": "Sullivan", "given": "William F", "initials": "WF", "orcid": "0000-0002-0520-0541", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e747cb9cd7f3443e8ef4432fc6204ca2.json"}}, {"family": "Bj\u00f6rne", "given": "Petra", "initials": "P", "orcid": "0000-0001-8085-2008", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/226848f597ca496cacf85b62ba73886c.json"}}, {"family": "Heng", "given": "John", "initials": "J", "orcid": "0000-0002-6080-580X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a04c6d3b0274883b6221f74dfd88eb9.json"}}, {"family": "Northway", "given": "Ruth", "initials": "R"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "J Policy Pract Intellect Disabil", "issn": "1741-1122", "volume": "19", "issue": "1", "pages": "116-124", "issn-l": null}, "abstract": "A growing body of knowledge highlights the negative impact of the COVID-19 pandemic on the health and well-being of many people with intellectual and developmental disabilities (IDDs) and their caregivers. The underlying reasons are not only due to biomedical factors but also ethical issues. They stem from longstanding and pervasive structural injustices and negative social attitudes that continue to devalue people with IDD and that underlie certain clinical decisions and frameworks for public-health policies during this pandemic. Unless these fundamental ethical shortcomings are addressed, pandemic responses will continue to undermine the human rights and well-being of people with IDD. This paper proposes an ethics framing for policy and practices regarding clinical care and public health based on Martha Nussbaum's approach to Capability Theory. Such a framework can reorient healthcare professionals and healthcare systems to support the capabilities of people with IDD to protect, recover, and promote health and well-being. It could be applied during this pandemic and in planning for future pandemics. The paper presents some practical recommendations that follow from applying this framework.", "doi": "10.1111/jppi.12413", "pmid": "35601010", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "JPPI12413"}, {"db": "pmc", "key": "PMC9115164"}], "notes": [], "created": "2022-06-21T17:56:57.068Z", "modified": "2022-06-21T17:56:57.217Z"}, {"entity": "publication", "iuid": "639c6314592045dbbc3fb5b75de89134", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/639c6314592045dbbc3fb5b75de89134.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/639c6314592045dbbc3fb5b75de89134"}}, "title": "Detection and isolation of airborne SARS-CoV-2 in a hospital setting.", "authors": [{"family": "Rufino de Sousa", "given": "Nuno", "initials": "N", "orcid": "0000-0002-0670-9788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1cb037a9e7f44a489dd84d6f5ba513d7.json"}}, {"family": "Steponaviciute", "given": "Laura", "initials": "L"}, {"family": "Margerie", "given": "Lucille", "initials": "L", "orcid": "0000-0001-9537-1231", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e7015e5251242ecb70df112f997182b.json"}}, {"family": "Nissen", "given": "Karolina", "initials": "K"}, {"family": "Kjellin", "given": "Midori", "initials": "M", "orcid": "0000-0002-1377-6014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cbf761ec44641a5a70ee1b8f7964a20.json"}}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Salaneck", "given": "Erik", "initials": "E"}, {"family": "Udekwu", "given": "Klas I", "initials": "KI"}, {"family": "Rothfuchs", "given": "Antonio Gigliotti", "initials": "AG", "orcid": "0000-0001-6001-7240", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00102c49ae2d41828272e850cd551c9f.json"}}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Indoor Air", "issn": "0905-6947", "volume": "32", "issue": "3", "pages": "e13023", "issn-l": null}, "abstract": "Transmission mechanisms for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are incompletely understood. In particular, aerosol transmission remains unclear, with viral detection in air and demonstration of its infection potential being actively investigated. To this end, we employed a novel electrostatic collector to sample air from rooms occupied by COVID-19 patients in a major Swedish hospital. Electrostatic air sampling in conjunction with extraction-free, reverse-transcriptase polymerase chain reaction (hid-RT-PCR) enabled detection of SARS-CoV-2 in air from patient rooms (9/22; 41%) and adjoining anterooms (10/22; 45%). Detection with hid-RT-PCR was concomitant with viral RNA presence on the surface of exhaust ventilation channels in patients and anterooms more than 2 m from the COVID-19 patient. Importantly, it was possible to detect active SARS-CoV-2 particles from room air, with a total of 496 plaque-forming units (PFUs) being isolated, establishing the presence of infectious, airborne SARS-CoV-2 in rooms occupied by COVID-19 patients. Our results support circulation of SARS-CoV-2 via aerosols and urge the revision of existing infection control frameworks to include airborne transmission.", "doi": "10.1111/ina.13023", "pmid": "35347788", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null, "Research Area: Pandemic preparedness": null, "Funder: KAW/SciLifeLab": null, "Category: Other": null, "Research Area: Diagnostics for virus": null}, "xrefs": [], "notes": [], "created": "2022-03-29T15:54:03.910Z", "modified": "2022-04-04T06:43:36.321Z"}, {"entity": "publication", "iuid": "53b1f06a77394293a23a2f053f38c850", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53b1f06a77394293a23a2f053f38c850.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53b1f06a77394293a23a2f053f38c850"}}, "title": "Consultations with health care providers and use of self-management strategies for prevention and treatment of COVID-19 related symptoms. A population based cross-sectional study in Norway, Sweden and the Netherlands.", "authors": [{"family": "Kristoffersen", "given": "Agnete E", "initials": "AE"}, {"family": "van der Werf", "given": "Esther T", "initials": "ET"}, {"family": "Stub", "given": "Trine", "initials": "T"}, {"family": "Musial", "given": "Frauke", "initials": "F"}, {"family": "Wider", "given": "Barbara", "initials": "B"}, {"family": "Jong", "given": "Miek C", "initials": "MC"}, {"family": "Wode", "given": "Kathrin", "initials": "K"}, {"family": "Danell", "given": "Jenny-Ann B", "initials": "JB"}, {"family": "Busch", "given": "Martine", "initials": "M"}, {"family": "Hoenders", "given": "H J Rogier", "initials": "HJR"}, {"family": "Nordberg", "given": "Johanna H", "initials": "JH"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Complement Ther Med", "issn": "1873-6963", "volume": "64", "pages": "102792", "issn-l": null}, "abstract": "The present study was initiated to determine consultations with health care providers and use of self-management strategies for prevention or treatment of COVID-19 related symptoms in countries with a full lockdown (Norway), a partial lockdown (the Netherlands) and no lockdown (Sweden) during the first three months of the COVID-19 pandemic, and if such use correlates with worries of being infected by COVID-19 disease.\n\nData were collected in collaboration with Ipsos A/S in April-June 2020. An adapted version of the International Questionnaire to measure use of Complementary and Alternative Medicine (I-CAM-Q) was used with the categories \"for prevention of COVID-19\" and \"to treat COVID-19-related symptoms\" added. Data were collected among a representative sample in Norway, Sweden and the Netherlands using data assisted telephone interviews (Norway, n=990 and Sweden, n=500), and an online survey (the Netherlands, n=1004). Total response rate was 30%.\n\nVery few consulted a health care provider with the intention to treat or prevent COVID-19 (1.2% and 1.0% respectively) with medical doctors mostly visited (1.0% and 0.9% respectively). Similarly, the use of self-management strategies to prevent or treat COVID-19 was low (3.4% and 0.2% respectively); most commonly used for prevention of COVID-19 were vitamins and minerals (2.8%). Consultations with health care providers and use of self-management strategies for prevention of COVID-19 were positively associated with worries of being infected with COVID-19.\n\nThe COVID-19 pandemic does not seem to have evoked a large-scale difference in behavior related to consultations with health care providers or the use of self-management strategies in any of the three countries.", "doi": "10.1016/j.ctim.2021.102792", "pmid": "34826590", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8609665"}, {"db": "pii", "key": "S0965-2299(21)00133-3"}], "notes": [], "created": "2021-12-18T18:18:07.845Z", "modified": "2023-01-13T13:50:24.202Z"}, {"entity": "publication", "iuid": "611e7570be744b3e9fcc1ac31c571e7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/611e7570be744b3e9fcc1ac31c571e7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/611e7570be744b3e9fcc1ac31c571e7e"}}, "title": "In-Flight Transmission of a SARS-CoV-2 Lineage B.1.617.2 Harbouring the Rare S:E484Q Immune Escape Mutation.", "authors": [{"family": "Martinell", "given": "Mats", "initials": "M"}, {"family": "Andersson", "given": "Tanja", "initials": "T"}, {"family": "Mannsverk", "given": "Steinar Sm\u00f8rholm", "initials": "SS"}, {"family": "Bergholm", "given": "Julia", "initials": "J"}, {"family": "Ellstr\u00f6m", "given": "Patrik", "initials": "P"}, {"family": "Hill", "given": "Anna", "initials": "A"}, {"family": "Lindh", "given": "Johan", "initials": "J"}, {"family": "Kaden", "given": "Rene", "initials": "R", "orcid": "0000-0002-2111-9751", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2be6374ef0bf4ba39e5f5dbbb059747f.json"}}], "type": "journal article", "published": "2022-02-28", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "3", "issn-l": "1999-4915"}, "abstract": "We describe a flight-associated infection scenario of seven individuals with a B.1.617.2 (Delta) lineage, harbouring an S:E484Q point mutation. In Sweden, at least 10% of all positive SARS-CoV-2 samples were sequenced in each county; the B.1.717.2 + S:E484Q combination was not detected in Sweden before and was imported within the scenario described in this report. The high transmission rate of the delta lineage combined with the S:E484Q mutation, associated with immune escape in other lineages, makes this specific genetic combination a possible threat to the global fight against the COVID-19 pandemic. Even within the Omicron wave, the B.1.617.2 + S:E484Q variant appeared in community samples in Sweden, as it seems that this combination has an evolutionary gain compared to other B.1.617.2 lineages. The here described genomic combination was not detectable with the common fasta file-based Pango-lineage analysis, hence increasing the probability of the true global prevalence to be higher.", "doi": "10.3390/v14030504", "pmid": "35336908", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "v14030504"}, {"db": "pmc", "key": "PMC8953675"}], "notes": [], "created": "2022-03-28T16:42:05.248Z", "modified": "2022-04-04T06:52:20.339Z"}, {"entity": "publication", "iuid": "0da027ce656c4236937fd53d3ff32362", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0da027ce656c4236937fd53d3ff32362.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0da027ce656c4236937fd53d3ff32362"}}, "title": "Short-term improvement of mental health after a COVID-19 vaccination", "authors": [{"family": "Chourpiliadis", "given": "Charilaos", "initials": "C", "orcid": "0000-0002-4733-5698", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60f9cb9172274531bc75c430eeb74a31.json"}}, {"family": "Lovik", "given": "Anik\u00f3", "initials": "A", "orcid": "0000-0002-6397-5011", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e50d5a79a1234cd79b22ec2eebf6f410.json"}}, {"family": "K\u00e4hler", "given": "Anna K", "initials": "AK", "orcid": "0000-0003-4047-4588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6d52ec01645417eb73e2bfe6c3106bd.json"}}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA", "orcid": "0000-0001-5382-946X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87d1dbec7c6f4942b1db2b999eeb9ece.json"}}, {"family": "Frans", "given": "Emma M", "initials": "EM", "orcid": "0000-0002-9791-687X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/157f412416124221ab8387bfaee3b75b.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF", "orcid": "0000-0002-6619-873X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f9632d685f348cea7a69ebfe51ad0ab.json"}}, {"family": "Fang", "given": "Fang", "initials": "F", "orcid": "0000-0002-3310-6456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b0852465cd14239a25329b976172792.json"}}], "type": "posted-content", "published": "2022-02-27", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.02.22.22271327", "pmid": null, "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Preprint": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-02-13T18:39:58.873Z", "modified": "2023-02-13T18:40:15.895Z"}, {"entity": "publication", "iuid": "45f65fcb21a545e79c2083314dda7609", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/45f65fcb21a545e79c2083314dda7609.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/45f65fcb21a545e79c2083314dda7609"}}, "title": "Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line.", "authors": [{"family": "Ald\u00e9n", "given": "Markus", "initials": "M", "orcid": "0000-0002-5166-0055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb334111adf44509a04451a8d3b36483.json"}}, {"family": "Olofsson Falla", "given": "Francisko", "initials": "F"}, {"family": "Yang", "given": "Daowei", "initials": "D"}, {"family": "Barghouth", "given": "Mohammad", "initials": "M"}, {"family": "Luan", "given": "Cheng", "initials": "C"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}, {"family": "De Marinis", "given": "Yang", "initials": "Y", "orcid": "0000-0002-8081-2142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c85c6f6e14a44415a2bea1cfe224e50c.json"}}], "type": "journal article", "published": "2022-02-25", "journal": {"title": "CIMB", "issn": "1467-3045", "volume": "44", "issue": "3", "pages": "1115-1126", "issn-l": null}, "abstract": "Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 injection. Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of human cells. In this study, we investigated the effect of BNT162b2 on the human liver cell line Huh7 in vitro. Huh7 cells were exposed to BNT162b2, and quantitative PCR was performed on RNA extracted from the cells. We detected high levels of BNT162b2 in Huh7 cells and changes in gene expression of long interspersed nuclear element-1 (LINE-1), which is an endogenous reverse transcriptase. Immunohistochemistry using antibody binding to LINE-1 open reading frame-1 RNA-binding protein (ORFp1) on Huh7 cells treated with BNT162b2 indicated increased nucleus distribution of LINE-1. PCR on genomic DNA of Huh7 cells exposed to BNT162b2 amplified the DNA sequence unique to BNT162b2. Our results indicate a fast up-take of BNT162b2 into human liver cell line Huh7, leading to changes in LINE-1 expression and distribution. We also show that BNT162b2 mRNA is reverse transcribed intracellularly into DNA in as fast as 6 h upon BNT162b2 exposure.", "doi": "10.3390/cimb44030073", "pmid": "35723296", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "cimb44030073"}, {"db": "pmc", "key": "PMC8946961"}], "notes": [], "created": "2022-06-20T18:01:55.926Z", "modified": "2022-08-17T12:44:56.372Z"}, {"entity": "publication", "iuid": "4df609687e91421ebc10c9fc487f13f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4df609687e91421ebc10c9fc487f13f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4df609687e91421ebc10c9fc487f13f9"}}, "title": "The impact of COVID-19 related regulations and restrictions on mobility and potential for sustained climate mitigation across the Netherlands, Sweden and the UK: a data-based commentary.", "authors": [{"family": "Corker", "given": "Elizabeth", "initials": "E", "orcid": "0000-0002-2055-7493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72e2b85d3fc048b782da99c5e92e2774.json"}}, {"family": "Mitev", "given": "Kaloyan", "initials": "K", "orcid": "0000-0001-6148-4852", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa5cfd4a1b0642948d3d3728807b025b.json"}}, {"family": "Nilsson Lewis", "given": "Astrid", "initials": "A", "orcid": "0000-0002-2090-4379", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94deaedf05ea44f695bde2bd28d091a9.json"}}, {"family": "Tamis", "given": "Milan", "initials": "M"}, {"family": "Bouman", "given": "Thijs", "initials": "T", "orcid": "0000-0001-7940-892X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98f3843dc2dd49df9b163eb18e96ba04.json"}}, {"family": "Holmlid", "given": "Stefan", "initials": "S", "orcid": "0000-0002-2529-4303", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3caccddc41004ca58051819bfcbe4c1c.json"}}, {"family": "Lambe", "given": "Fiona", "initials": "F", "orcid": "0000-0003-3664-9891", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b83be50ea2ce4109a7f62a21760c0e22.json"}}, {"family": "Michie", "given": "Susan", "initials": "S", "orcid": "0000-0003-0063-6378", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2da07e2d6bd54e6aa3d3496c8bdac4d8.json"}}, {"family": "Osborne", "given": "Matthew", "initials": "M", "orcid": "0000-0003-0272-1496", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e75a8ae678b48078261ace855732360.json"}}, {"family": "Jan Renes", "given": "Reint", "initials": "R", "orcid": "0000-0003-2448-9480", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4926b953047471e9cc46fa18e978dff.json"}}, {"family": "Steg", "given": "Linda", "initials": "L", "orcid": "0000-0002-8375-9607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87f6c790280e4a17836805c5cd9beb80.json"}}, {"family": "Whitmarsh", "given": "Lorraine", "initials": "L", "orcid": "0000-0002-9054-1040", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d350670e761467cbfe8a92f59075ab6.json"}}], "type": "journal article", "published": "2022-02-24", "journal": {"title": "UCL Open Environ", "issn": "2632-0886", "issn-l": null, "volume": "4", "issue": null, "pages": "e032"}, "abstract": "Human behaviour change is necessary to meet targets set by the Paris Agreement to mitigate climate change. Restrictions and regulations put in place globally to mitigate the spread of COVID-19 during 2020 have had a substantial impact on everyday life, including many carbon-intensive behaviours such as transportation. Changes to transportation behaviour may reduce carbon emissions. Behaviour change theory can offer perspective on the drivers and influences of behaviour and shape recommendations for how policy-makers can capitalise on any observed behaviour changes that may mitigate climate change. For this commentary, we aimed to describe changes in data relating to transportation behaviours concerning working from home during the COVID-19 pandemic across the Netherlands, Sweden and the UK. We display these identified changes in a concept map, suggesting links between the changes in behaviour and levels of carbon emissions. We consider these changes in relation to a comprehensive and easy to understand model of behaviour, the Opportunity, Motivation Behaviour (COM-B) model, to understand the capabilities, opportunities and behaviours related to the observed behaviour changes and potential policy to mitigate climate change. There is now an opportunity for policy-makers to increase the likelihood of maintaining pro-environmental behaviour changes by providing opportunities, improving capabilities and maintaining motivation for these behaviours.", "doi": "10.14324/111.444/ucloe.000032", "pmid": "37228472", "labels": {"Category: Social Science & Humanities": null, "Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10208342"}], "notes": [], "created": "2023-10-04T05:12:20.944Z", "modified": "2023-10-04T08:15:41.184Z"}, {"entity": "publication", "iuid": "4ab647b562b74e799cbad8075838427f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ab647b562b74e799cbad8075838427f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ab647b562b74e799cbad8075838427f"}}, "title": "Duration of SARS-CoV-2 Immune Responses Up to Six Months Following Homologous or Heterologous Primary Immunization with ChAdOx1 nCoV-19 and BNT162b2 mRNA Vaccines.", "authors": [{"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f28f2f6ac9648629c2d2de92fe7bb59.json"}}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/305bca9e5c6c423898c272bf06ce2f2a.json"}}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Nilsson", "given": "Charlotta", "initials": "C"}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2022-02-24", "journal": {"title": "Vaccines", "issn": "2076-393X", "issn-l": null, "volume": "10", "issue": "3", "pages": "359"}, "abstract": "Heterologous primary immunization against SARS-CoV-2 is part of applied recommendations. However, little is known about duration of immune responses after heterologous vaccine regimens. To evaluate duration of immune responses after primary vaccination with homologous adeno-vectored ChAdOx1 nCoV-19 vaccine (ChAd) or heterologous ChAd/BNT162b2 mRNA vaccine (BNT), anti-spike-IgG and SARS-CoV-2 VOC-neutralizing antibody responses were measured in 354 healthcare workers (HCW) at 2 weeks, 3 months, 5 months and 6 months after the second vaccine dose. T-cell responses were investigated using a whole blood interferon gamma (IFN-\u03b3) release assay 2 weeks and 3 months post second vaccine dose. Two hundred and ten HCW immunized with homologous BNT were enrolled for comparison of antibody responses. In study participants na\u00efve to SARS-CoV-2 prior to vaccination, heterologous ChAd/BNT resulted in 6-fold higher peak anti-spike IgG antibody titers compared to homologous ChAd vaccination. The half-life of antibody titers was 3.1 months (95% CI 2.8-3.6) following homologous ChAd vaccination and 1.9 months (95% CI 1.7-2.1) after heterologous vaccination, reducing the GMT difference between the groups to 3-fold 6 months post vaccination. Peak T-cell responses were stronger in ChAd/BNT vaccinees, but no significant difference was observed 3 months post vaccination. SARS-CoV-2 infection prior to vaccination resulted in substantially higher peak GMTs and IFN-\u03b3 levels and enhanced SARS-CoV-2 specific antibody and T cell responses over time. Heterologous primary SARS-CoV-2 immunization with ChAd and BNT elicits a stronger initial immune response compared to homologous vaccination with ChAd. However, although the differences in humoral responses remain over 6 months, the difference in SARS-CoV-2 specific T cell responses are no longer significant three months after vaccination.", "doi": "10.3390/vaccines10030359", "pmid": "35334989", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null, "Funder: VR": null, "Research Area: Drug discovery and repurposing of drugs": null, "Research Area: High-throughput and high-content serology": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC8953845"}, {"db": "pii", "key": "vaccines10030359"}], "notes": [], "created": "2022-03-28T16:45:51.963Z", "modified": "2023-06-19T14:27:58.481Z"}, {"entity": "publication", "iuid": "248d757ee8874cc4a15d38810b8a6e3e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/248d757ee8874cc4a15d38810b8a6e3e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/248d757ee8874cc4a15d38810b8a6e3e"}}, "title": "Influence of the COVID-19 pandemic on abortions and births in Sweden: a mixed-methods study.", "authors": [{"family": "Rydelius", "given": "Johanna", "initials": "J", "orcid": "0000-0003-3480-9177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93fdadd0e5504aa9bedb5f5f8071051b.json"}}, {"family": "Edalat", "given": "Mina", "initials": "M"}, {"family": "Nyman", "given": "Viola", "initials": "V"}, {"family": "Jar-Allah", "given": "Tagrid", "initials": "T", "orcid": "0000-0002-4394-6299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a4815ddb6224ebd8e14cbaa36b7166b.json"}}, {"family": "Milsom", "given": "Ian", "initials": "I"}, {"family": "Hognert", "given": "Helena", "initials": "H"}], "type": "journal article", "published": "2022-02-23", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "2", "pages": "e054076", "issn-l": "2044-6055"}, "abstract": "Although considered an essential service by the WHO, there are indications that access to induced abortion care has been restricted during the COVID-19 pandemic.\n\nTo investigate if the number of induced abortions and ongoing pregnancies changed during the first pandemic wave of COVID-19 in 2020 compared with recent years prior to the pandemic and explore possible reasons for the findings.\n\nConvergent parallel mixed-methods design. Collection of quantitative data from the Swedish National Board of Health and Welfare and the Swedish Pregnancy Register, and qualitative data from interviews.\n\nNational data on abortions (January 2018-June 2020) and births (January 2018-March 2021). Interviews performed at the main abortion clinic, Gothenburg, Sweden, in June 2020.\n\nAll women aged 15-44 years living in Sweden 2018-2020, approximately 1.9 million. 15 women who sought abortion were interviewed.\n\nNumber of abortions and births/1000 women aged 15-44 years. Themes and subthemes identified from interviews.\n\nThe number of abortions and ongoing pregnancies did not change significantly during the study period compared with before the pandemic started. Interview themes identified were the following: meeting with abortion care during the COVID-19 pandemic (availability, and fear of being infected and infecting others); and the impact of the COVID-19 pandemic on the abortion decision (to catch COVID-19 during pregnancy, feelings of loneliness and isolation, and social aspects).\n\nThis study shows that the number of abortions and ongoing pregnancies remained unchanged during the first wave of the COVID-19 pandemic in 2020 in Sweden compared with before the start of the pandemic. Abortion-seeking women did not hesitate to proceed with the abortion. The women expressed a number of fears concerning both availability of care and their health, which could have been properly addressed by the authorities.", "doi": "10.1136/bmjopen-2021-054076", "pmid": "35197343", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8882666"}, {"db": "pii", "key": "bmjopen-2021-054076"}], "notes": [], "created": "2023-01-13T13:33:02.465Z", "modified": "2023-01-13T13:33:02.532Z"}, {"entity": "publication", "iuid": "29818ab97c8a40bdaa3e46989a7512f3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/29818ab97c8a40bdaa3e46989a7512f3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/29818ab97c8a40bdaa3e46989a7512f3"}}, "title": "Evaluation of Simple Lateral Flow Immunoassays for Detection of SARS-CoV-2 Neutralizing Antibodies.", "authors": [{"family": "Nickel", "given": "Olaf", "initials": "O"}, {"family": "Rockstroh", "given": "Alexandra", "initials": "A", "orcid": "0000-0003-1317-5857", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0f920f4daa4468ca4826d82f45f647d.json"}}, {"family": "Borte", "given": "Stephan", "initials": "S"}, {"family": "Wolf", "given": "Johannes", "initials": "J"}], "type": "journal article", "published": "2022-02-23", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "3", "issn-l": null}, "abstract": "Immunization for the generation of protective antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged to be highly effective in preventing hospital admission, need for intensive care treatment and high mortality in the current SARS-CoV-2 pandemic. Lateral flow immune assays (LFIAs) offer a simple and competitive option to monitor antibody production after vaccination. Here, we compared the diagnostic performance of three different lateral flow assays in detecting nucleocapsid protein (NP), S1 subunit (S1) and receptor binding domain (pseudo)-neutralizing antibodies (nRBD) in sera of 107 health care workers prior (V1), two weeks (V2) after first vaccination with BNT162b2 as well as three weeks (V3) and eight months later (V4). In sera at V1, overall specificity was &gt;99%. At V3, LFIAs showed sensitivities between 98.1 and 100%. The comparison of S1 and nRBD LFIA with S1 ELISA and a focus reduction neutralization assay (FRNT) revealed high concordance at V3. Thus, the use of lateral flow immunoassays appears to have reasonable application in the short-term follow-up after vaccination for SARS-CoV-2.", "doi": "10.3390/vaccines10030347", "pmid": "35334979", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "vaccines10030347"}, {"db": "pmc", "key": "PMC8949379"}], "notes": [], "created": "2022-04-04T06:56:07.322Z", "modified": "2022-04-04T06:56:07.376Z"}, {"entity": "publication", "iuid": "2c7797a41e6e44f99348af9ff69c55fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c7797a41e6e44f99348af9ff69c55fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c7797a41e6e44f99348af9ff69c55fa"}}, "title": "Analysis of B Cell Receptor Repertoires Reveals Key Signatures of the Systemic B Cell Response after SARS-CoV-2 Infection.", "authors": [{"family": "Zhang", "given": "Yudi", "initials": "Y"}, {"family": "Yan", "given": "Qihong", "initials": "Q"}, {"family": "Luo", "given": "Kun", "initials": "K"}, {"family": "He", "given": "Ping", "initials": "P"}, {"family": "Hou", "given": "Ruitian", "initials": "R"}, {"family": "Zhao", "given": "Xinwei", "initials": "X"}, {"family": "Wang", "given": "Qian", "initials": "Q"}, {"family": "Yi", "given": "Haisu", "initials": "H"}, {"family": "Liang", "given": "Huan", "initials": "H"}, {"family": "Deng", "given": "Yijun", "initials": "Y"}, {"family": "Hu", "given": "Fengyu", "initials": "F"}, {"family": "Li", "given": "Feng", "initials": "F"}, {"family": "Liu", "given": "Xinglong", "initials": "X"}, {"family": "Feng", "given": "Ying", "initials": "Y"}, {"family": "Li", "given": "Pingchao", "initials": "P"}, {"family": "Qu", "given": "Linbing", "initials": "L"}, {"family": "Chen", "given": "Zhaoming", "initials": "Z"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}, {"family": "Feng", "given": "Liqiang", "initials": "L", "orcid": "0000-0001-6811-2074", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14d1a8f7ddbc4eeeb9f23a2efc12a2fd.json"}}, {"family": "Niu", "given": "Xuefeng", "initials": "X"}, {"family": "Chen", "given": "Ling", "initials": "L", "orcid": "0000-0003-1485-1626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b461d2c202447e6b4bc7ec60a46f51b.json"}}], "type": "journal article", "published": "2022-02-23", "journal": {"title": "J Virol", "issn": "1098-5514", "pages": "e0160021", "volume": "96", "issue": "4", "issn-l": "0022-538X"}, "abstract": "A comprehensive study of the B cell response against SARS-CoV-2 could be significant for understanding the immune response and developing therapeutical antibodies and vaccines. To define the dynamics and characteristics of the antibody repertoire following SARS-CoV-2 infection, we analyzed the mRNA transcripts of immunoglobulin heavy chain (IgH) repertoires of 24 peripheral blood samples collected between 3 and 111 days after symptom onset from 10 COVID-19 patients. Massive clonal expansion of naive B cells with limited somatic hypermutation (SHM) was observed in the second week after symptom onset. The proportion of low-SHM IgG clones strongly correlated with spike-specific IgG antibody titers, highlighting the significant activation of naive B cells in response to a novel virus infection. The antibody isotype switching landscape showed a transient IgA surge in the first week after symptom onset, followed by a sustained IgG elevation that lasted for at least 3 months. SARS-CoV-2 infection elicited poly-germ line reactive antibody responses. Interestingly, 17 different IGHV germ line genes recombined with IGHJ6 showed significant clonal expansion. By comparing the IgH repertoires that we sequenced with the 774 reported SARS-CoV-2-reactive monoclonal antibodies (MAbs), 13 shared spike-specific IgH clusters were found. These shared spike-specific IgH clusters are derived from the same lineage of several recently published neutralizing MAbs, including CC12.1, CC12.3, C102, REGN10977, and 4A8. Furthermore, identical spike-specific IgH sequences were found in different COVID-19 patients, suggesting a highly convergent antibody response to SARS-CoV-2. Our analysis based on sequencing antibody repertoires from different individuals revealed key signatures of the systemic B cell response induced by SARS-CoV-2 infection. IMPORTANCE Although the canonical delineation of serum antibody responses following SARS-CoV-2 infection has been well established, the dynamics of antibody repertoire at the mRNA transcriptional level has not been well understood, especially the correlation between serum antibody titers and the antibody mRNA transcripts. In this study, we analyzed the IgH transcripts and characterized the B cell clonal expansion and differentiation, isotype switching, and somatic hypermutation in COVID-19 patients. This study provided insights at the repertoire level for the B cell response after SARS-CoV-2 infection.", "doi": "10.1128/JVI.01600-21", "pmid": "34878902", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8865482"}], "notes": [], "created": "2021-12-12T07:15:16.732Z", "modified": "2023-06-19T15:34:31.225Z"}, {"entity": "publication", "iuid": "3a9d5263f1c44630b90a37fbb88a8ae0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a9d5263f1c44630b90a37fbb88a8ae0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a9d5263f1c44630b90a37fbb88a8ae0"}}, "title": "SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells.", "authors": [{"family": "Hammer", "given": "Quirin", "initials": "Q"}, {"family": "Dunst", "given": "Josefine", "initials": "J"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Picarazzi", "given": "Francesca", "initials": "F"}, {"family": "Wendorff", "given": "Mareike", "initials": "M"}, {"family": "Momayyezi", "given": "Pouria", "initials": "P"}, {"family": "Huhn", "given": "Ois\u00edn", "initials": "O"}, {"family": "Netskar", "given": "Herman K", "initials": "HK"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Garc\u00eda", "given": "Marina", "initials": "M"}, {"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "Sohlberg", "given": "Ebba", "initials": "E"}, {"family": "Azzimato", "given": "Valerio", "initials": "V"}, {"family": "Aouadi", "given": "Myriam", "initials": "M"}, {"family": "Karolinska COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Severe COVID-19 GWAS Group", "given": "", "initials": ""}, {"family": "Degenhardt", "given": "Frauke", "initials": "F"}, {"family": "Franke", "given": "Andre", "initials": "A"}, {"family": "Spallotta", "given": "Francesco", "initials": "F"}, {"family": "Mori", "given": "Mattia", "initials": "M"}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "R\u00fcckert", "given": "Timo", "initials": "T"}, {"family": "Romagnani", "given": "Chiara", "initials": "C"}, {"family": "Horowitz", "given": "Amir", "initials": "A"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Malmberg", "given": "Karl-Johan", "initials": "K"}], "type": "journal article", "published": "2022-02-21", "journal": {"title": "Cell Rep", "issn": "2211-1247", "issn-l": null, "volume": null, "issue": null, "pages": "110503"}, "abstract": "Natural killer (NK) cells are innate immune cells that contribute to host defense against virus infections. NK cells respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and are activated in patients with acute coronavirus disease 2019 (COVID-19). However, by which mechanisms NK cells detect SARS-CoV-2-infected cells remains largely unknown. Here, we show that the Non-structural protein 13 of SARS-CoV-2 encodes for a peptide that is presented by human leukocyte antigen E (HLA-E). In contrast with self-peptides, the viral peptide prevents binding of HLA-E to the inhibitory receptor NKG2A, thereby rendering target cells susceptible to NK cell attack. In line with these observations, NKG2A-expressing NK cells are particularly activated in patients with COVID-19 and proficiently limit SARS-CoV-2 replication in infected lung epithelial cells in vitro. Thus, these data suggest that a viral peptide presented by HLA-E abrogates inhibition of NKG2A+ NK cells, resulting in missing self-recognition.", "doi": "10.1016/j.celrep.2022.110503", "pmid": "35235832", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2211-1247(22)00239-X"}, {"db": "URL", "key": "https://covid19cellatlas.com/", "description": "https://covid19cellatlas.com/"}], "notes": [], "created": "2022-03-04T06:21:37.615Z", "modified": "2022-03-04T06:22:07.859Z"}, {"entity": "publication", "iuid": "e857ddb683104a0f8f752d24ed30fb87", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e857ddb683104a0f8f752d24ed30fb87.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e857ddb683104a0f8f752d24ed30fb87"}}, "title": "A cohort study of trauma patients in Sweden during the first months of the COVID-19 pandemic: a small reduction in trauma admissions.", "authors": [{"family": "B\u00e4ckstr\u00f6m", "given": "Denise", "initials": "D", "orcid": "0000-0003-4075-4600", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b67dde528cb4fa2b5df5ab9c15f9faa.json"}}, {"family": "Wladis", "given": "Andreas", "initials": "A", "orcid": "0000-0003-4377-0892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e5c5716282a4d63a4ade70eb160f432.json"}}], "type": "journal article", "published": "2022-02-19", "journal": {"title": "Scand J Trauma Resusc Emerg Med", "issn": "1757-7241", "volume": "30", "issue": "1", "pages": "12", "issn-l": "1757-7241"}, "abstract": "Given that Swedish authorities have been widely viewed as having practiced an unusual approach to the COVID-19 pandemic and given that Sweden is notable for a low incidence of trauma, we wanted to learn how the pandemic may have affected the number of trauma admissions in Sweden.\n\nWe conducted a retrospective cohort study based on the Swedish trauma registry (Svenska Traumaregistret). The study period was March 1, 2020 to June 30, 2020. As a basis for comparison, the record for the same time during the previous year, 2019 was used.\n\nDuring the four months of the first wave of COVID-19, 2020 there was a decline of 24.2% in the total number of trauma patients in Sweden. There was no significant change in 30-day mortality rates, 4.7% 2019 and 5.1% 2020, (p = 0.30). The number of injuries per patient was higher during the pandemic 3.8 injuries 2019 and 4.1 injuries 2020 (p = 0.02). The NISS 6, 2019 and 8, 2020 was higher during the pandemic.\n\nAs a consequence of what were seen by many as all too lenient actions taken to deal with COVID-19 in Sweden during spring 2020, there was still a reduction in trauma admissions most likely due to an adherence to the voluntary recommendations, the reduction was not as prominent as what was seen in many countries with harsher restrictions and lockdowns.", "doi": "10.1186/s13049-022-01001-9", "pmid": "35183237", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8857878"}, {"db": "pii", "key": "10.1186/s13049-022-01001-9"}], "notes": [], "created": "2023-01-13T13:43:40.759Z", "modified": "2023-01-13T13:43:40.841Z"}, {"entity": "publication", "iuid": "3f2c42bc11e742e0a6ecca5cad896f2b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f2c42bc11e742e0a6ecca5cad896f2b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f2c42bc11e742e0a6ecca5cad896f2b"}}, "title": "Prevalence and predictive factors of complementary medicine use during the first wave of the COVID-19 pandemic of 2020 in the Netherlands.", "authors": [{"family": "Mulder", "given": "Louise T C", "initials": "LTC"}, {"family": "Busch", "given": "Martine", "initials": "M"}, {"family": "Kristoffersen", "given": "Agnete E", "initials": "AE"}, {"family": "H\u00f6k Nordberg", "given": "Johanna", "initials": "J"}, {"family": "van der Werf", "given": "Esther T", "initials": "ET"}], "type": "journal article", "published": "2022-02-15", "journal": {"title": "BMC Complement Med Ther", "issn": "2662-7671", "volume": "22", "issue": "1", "pages": "43", "issn-l": null}, "abstract": "Major life changing events such as the COVID-19 pandemic may have major impact on one's health and general well-being. This study aimed to determine the prevalence and predictive factors, including gender specific differences, of Complementary Medicine (CM) use (including CM consultations, self-care management and self-help techniques) during the first wave of the COVID-19 pandemic in 2020 in the Netherlands.\n\nCM use was studied among a random representative sample (n = 1004) of the adult Dutch population using an online survey conducted from 22-27 May 2020. The survey included a modified version of I-CAM-Q and additional questions on demographic characteristics, reasons for CM use, perceived effectiveness and side effects.\n\n68.0% of the participants reported to have used CM (CM consultations (13.3%), self-management strategies (59.4%), self-help techniques (30.0%)). Most frequently reported reason of CM use was to improve general well-being (61.6%), prevention and/or treatment of COVID-19 was only reported by 10%. Perceived effectiveness of CM was high and number of experienced side effects low. Being a women, worried to get infected with COVID-19, higher education and living in northern/ middle region of the Netherlands were predictive factors to use CM.\n\nIn the Netherlands, specific groups (e.g. women/ highly educated) use CM, mainly to improve general wellbeing, and seem to benefit of it during the first months of the pandemic. The high perceived effectiveness and low reporting of side effects should encourage medical professionals and policy makers for more openness towards considering CM as being part of an integrative approach to public health in times life changing events occur.", "doi": "10.1186/s12906-022-03528-x", "pmid": "35168630", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12906-022-03528-x"}], "notes": [], "created": "2022-02-17T06:06:01.985Z", "modified": "2022-02-17T06:06:02.017Z"}, {"entity": "publication", "iuid": "1d0e188b725548c192dee5a9bea8fc74", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d0e188b725548c192dee5a9bea8fc74.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d0e188b725548c192dee5a9bea8fc74"}}, "title": "An extended version of Necessary Condition Analysis (NCA) allows more specific conclusions: an example involving well-being and resilience.", "authors": [{"family": "Sorjonen", "given": "Kimmo", "initials": "K"}, {"family": "Melin", "given": "Bo", "initials": "B"}], "type": "journal article", "published": "2022-02-15", "journal": {"title": "BMC Psychiatry", "issn": "1471-244X", "volume": "22", "issue": "1", "pages": "121", "issn-l": null}, "abstract": "After conducting necessary condition analysis (NCA), researchers have concluded that a certain, not too low, level of well-being is necessary but not sufficient for a high level of resilience. However, as acknowledged by the developers of the test, NCA only evaluates if the association between two variables is characterized by some unspecified type of non-randomness and not conditions of necessity.\n\nEarlier reported data on the association between well-being and resilience among Filipino adults (N = 533) in COVID-19 quarantine were re-analyzed with an extended version of NCA.\n\nAnalyses indicated a significant necessity effect of resilience on overall well-being, which is not logically compatible with well-being being necessary but not sufficient for resilience. Analyses with an extended version of NCA suggested that the association between overall well-being and resilience was characterized by equal degrees of necessity and sufficiency.\n\nThe original version of NCA is only capable of evaluating if the association between two variables is characterized by some unspecified type of non-randomness. The extended version of NCA allows researchers to draw more specific conclusions.", "doi": "10.1186/s12888-022-03774-w", "pmid": "35168598", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12888-022-03774-w"}], "notes": [], "created": "2022-02-17T06:06:20.614Z", "modified": "2022-02-17T06:06:20.629Z"}, {"entity": "publication", "iuid": "5f5fd2ae90834b769970e07dfc15b2ba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f5fd2ae90834b769970e07dfc15b2ba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f5fd2ae90834b769970e07dfc15b2ba"}}, "title": "Ventilator-Associated Lower Respiratory Tract Bacterial Infections in COVID-19 Compared With Non-COVID-19 Patients.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P"}, {"family": "Ternhag", "given": "Anders", "initials": "A"}, {"family": "Giske", "given": "Christian G", "initials": "CG"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "\u00d6zenci", "given": "Volkan", "initials": "V"}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Spindler", "given": "Carl", "initials": "C"}, {"family": "Hedlund", "given": "Jonas", "initials": "J"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2022-02-14", "journal": {"title": "Crit Care Med", "issn": "1530-0293", "issn-l": null}, "abstract": "Ventilator-associated lower respiratory tract infections (VA-LRTIs) are associated with prolonged length of stay and increased mortality. We aimed to investigate the occurrence of bacterial VA-LRTI among mechanically ventilated COVID-19 patients and compare these findings to non-COVID-19 cohorts throughout the first and second wave of the pandemic.\n\nRetrospective cohort study.\n\nKarolinska University Hospital, Stockholm, Sweden.\n\nAll patients greater than or equal to 18 years treated with mechanical ventilation between January 1, 2011, and December 31, 2020.\n\nNone.\n\nThe cohort consisted of 20,223 ICU episodes (479 COVID-19), with a VA-LRTI incidence proportion of 30% (129/426) in COVID-19 and 18% (1,081/5,907) in non-COVID-19 among patients ventilated greater than or equal to 48 hours. The median length of ventilator treatment for COVID-19 patients was 10 days (interquartile range, 5-18 d), which was significantly longer than for all other investigated specific diagnoses. The VA-LRTI incidence rate per 1,000 ventilator days at risk was 31 (95% CI, 26-37) for COVID-19 and 34 (95% CI, 32-36) for non-COVID-19. With COVID-19 as reference, adjusted subdistribution hazard ratios for VA-LRTI was 0.29-0.50 (95% CI, < 1) for influenza, bacterial pneumonia, acute respiratory distress syndrome, and severe sepsis, but 1.38 (95% CI, 1.15-1.65) for specific noninfectious diagnoses. Compared with COVID-19 in the first wave of the pandemic, COVID-19 in the second wave had adjusted subdistribution hazard ratio of 1.85 (95% CI, 1.14-2.99). In early VA-LRTI Staphylococcus aureus was more common and Streptococcus pneumoniae, Haemophilus influenzae, and Escherichia coli less common in COVID-19 patients, while Serratia species was more often identified in late VA-LRTI.\n\nCOVID-19 is associated with exceptionally long durations of mechanical ventilation treatment and high VA-LRTI occurrence proportions. The incidence rate of VA-LRTI was compared with the pooled non-COVID-19 cohort, however, not increased in COVID-19. Significant differences in the incidence of VA-LRTI occurred between the first and second wave of the COVID-19 pandemic.", "doi": "10.1097/CCM.0000000000005462", "pmid": "35148524", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "00003246-900000000-94988"}], "notes": [], "created": "2022-02-17T06:15:35.140Z", "modified": "2022-02-17T06:15:35.176Z"}, {"entity": "publication", "iuid": "7a8e4aefcd1740baa1e0c375af71e6fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a8e4aefcd1740baa1e0c375af71e6fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a8e4aefcd1740baa1e0c375af71e6fc"}}, "title": "COVID-19 related distress in the Swedish population: Validation of the Swedish version of the COVID Stress Scales (CSS).", "authors": [{"family": "Carlander", "given": "Anders", "initials": "A", "orcid": "0000-0002-4435-7648", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb81228e2951462ab407f261fa9e6d02.json"}}, {"family": "Lekander", "given": "Mats", "initials": "M"}, {"family": "Asmundson", "given": "Gordon J G", "initials": "GJG"}, {"family": "Taylor", "given": "Steven", "initials": "S"}, {"family": "Olofsson Bagge", "given": "Roger", "initials": "R"}, {"family": "Lindqvist Bagge", "given": "Ann-Sophie", "initials": "AS"}], "type": "journal article", "published": "2022-02-14", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "2", "pages": "e0263888", "issn-l": "1932-6203"}, "abstract": "The COVID Stress Scales (CSS) assess health- and contamination-related distress in the face of a medical outbreak like the ongoing COVID-19 pandemic. Though the CSS is translated into 21 languages, it has not been validated in a Swedish national sample.\n\nOur general objective is to provide a translation, replication, and validation of the CSS and test its convergent- and discriminant validity in relation to anxiety, health anxiety, depression, and stress in the general Swedish population. We also present latent psychometric properties by modelling based on item response theory.\n\nParticipants consisted of 3044 Swedish adults (> 18 years) from a pre-stratified (gender, age, and education) sample from The Swedish Citizen Panel. Mental health status was assessed by validated instruments, including the CSS, PHQ-4, SHAI-14, and PSS-10.\n\nResults indicate that our Swedish translation of CSS has good psychometric properties and consists of 5 correlated factors.\n\nThe CSS is useful either as a unidimensional or multidimensional construct using the CSS scales to measure key facets of pandemic-related stress.\n\nThe findings support the cross-cultural validity of the CSS and its potential utility in understanding many of the emotional challenges posed by the current and future pandemics.", "doi": "10.1371/journal.pone.0263888", "pmid": "35157739", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-37902"}], "notes": [], "created": "2022-02-17T06:11:53.292Z", "modified": "2022-02-17T06:11:53.339Z"}, {"entity": "publication", "iuid": "7fab07b5f64e4a5393a2b95e5f9286dc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7fab07b5f64e4a5393a2b95e5f9286dc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7fab07b5f64e4a5393a2b95e5f9286dc"}}, "title": "Association between pharmaceutical modulation of oestrogen in postmenopausal women in Sweden and death due to COVID-19: a cohort study.", "authors": [{"family": "Sund", "given": "Malin", "initials": "M"}, {"family": "Fonseca-Rodr\u00edguez", "given": "Osvaldo", "initials": "O"}, {"family": "Josefsson", "given": "Andreas", "initials": "A"}, {"family": "Welen", "given": "Karin", "initials": "K"}, {"family": "Fors Connolly", "given": "Anne-Marie", "initials": "AM", "orcid": "0000-0001-9215-4047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff46cc7d9e374929a14350748727ba60.json"}}], "type": "journal article", "published": "2022-02-14", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "2", "pages": "e053032", "issn-l": "2044-6055"}, "abstract": "Determine whether augmentation of oestrogen in postmenopausal women decreases the risk of death following COVID-19.\n\nNationwide registry-based study in Sweden based on registries from the Swedish Public Health Agency (all individuals who tested positive for SARS-CoV-2); Statistics Sweden (socioeconomical variables) and the National Board of Health and Welfare (causes of death).\n\nPostmenopausal women between 50 and 80 years of age with verified COVID-19.\n\nPharmaceutical modulation of oestrogen as defined by (1) women with previously diagnosed breast cancer and receiving endocrine therapy (decreased systemic oestrogen levels); (2) women receiving hormone replacement therapy (increased systemic oestrogen levels) and (3) a control group not fulfilling requirements for group 1 or 2 (postmenopausal oestrogen levels). Adjustments were made for potential confounders such as age, annual disposable income (richest group as the reference category), highest level of education (primary, secondary and tertiary (reference)) and the weighted Charlson Comorbidity Index (wCCI).\n\nDeath following COVID-19.\n\nFrom a nationwide cohort consisting of 49 853 women diagnosed with COVID-19 between 4 February and 14 September 2020 in Sweden, 16 693 were between 50 and 80 years of age. We included 14 685 women in the study with 11 923 (81%) in the control group, 227 (2%) women in group 1 and 2535 (17%) women in group 2. The unadjusted ORs for death following COVID-19 were 2.35 (95% CI 1.51 to 3.65) for group 1 and 0.45 (0.34 to 0.6) for group 2. Only the adjusted OR for death remained significant for group 2 with OR 0.47 (0.34 to 0.63). Absolute risk of death was 4.6% for the control group vs 10.1% and 2.1%, for the decreased and increased oestrogen groups, respectively. The risk of death due to COVID-19 was significantly associated with: age, OR 1.15 (1.14 to 1.17); annual income, poorest 2.79 (1.96 to 3.97), poor 2.43 (91.71 to 3.46) and middle 1.64 (1.11 to 2.41); and education (primary 1.4 (1.07 to 1.81)) and wCCI 1.13 (1.1 to 1.16).\n\nOestrogen supplementation in postmenopausal women is associated with a decreased risk of dying from COVID-19 in this nationwide cohort study. These findings are limited by the retrospective and non-randomised design. Further randomised intervention trials are warranted.", "doi": "10.1136/bmjopen-2021-053032", "pmid": "35165090", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-053032"}], "notes": [], "created": "2022-02-17T06:07:13.014Z", "modified": "2022-02-17T06:07:27.088Z"}, {"entity": "publication", "iuid": "23d4b34eef6e4dc8b4019dc8d6f32450", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23d4b34eef6e4dc8b4019dc8d6f32450.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23d4b34eef6e4dc8b4019dc8d6f32450"}}, "title": "Assessment of maternal and child health care services performance in the context of COVID-19 pandemic in Addis Ababa, Ethiopia: evidence from routine service data.", "authors": [{"family": "Gebreegziabher", "given": "Senedu Bekele", "initials": "SB"}, {"family": "Marrye", "given": "Solomon Sisay", "initials": "SS"}, {"family": "Kumssa", "given": "Tsegaye Hailu", "initials": "TH"}, {"family": "Merga", "given": "Kassa Haile", "initials": "KH"}, {"family": "Feleke", "given": "Alemu Kibret", "initials": "AK"}, {"family": "Dare", "given": "Degu Jerene", "initials": "DJ"}, {"family": "Hallstr\u00f6m", "given": "Inger Kristensson", "initials": "IK"}, {"family": "Yimer", "given": "Solomon Abebe", "initials": "SA"}, {"family": "Shargie", "given": "Mulatu Biru", "initials": "MB"}], "type": "journal article", "published": "2022-02-14", "journal": {"title": "Reprod Health", "issn": "1742-4755", "volume": "19", "issue": "1", "pages": "42", "issn-l": null}, "abstract": "In many settings, health care service provision has been modified to managing COVID-19 cases, and this has been affecting the provision of maternal and child health services. The aim of this study was to assess trends in selected maternal and child health services performance in the context of COVID-19 pandemic.\n\nA cross-sectional data review was conducted in Addis Ababa, Ethiopia from April to May 2021. Routine health management information system database was reviewed from Addis Ababa Health Bureau for the period from July 2019 to March 2021 across all quarters. Proportion and mean with standard deviation were computed. T-test was used to assess statistically significant differences in services mean performance.\n\nPostnatal care visit, new contraceptives accepters, safe abortion care and number of under-5 years old children treated for pneumonia significantly decreased by 9.3% (p-value 0.04), 20.3% (p-value 0.004), 23.7% (p-value 0.01) and 77.2% (p-value < 0.001), respectively during the first 8 months of the COVID-19 pandemic compared to the previous 8 months' average performance. The trends in Antenatal care first visit, new contraceptive accepters, pentavalent-3 vaccination and under-five children treated for pneumonia began to decline in January to March 2020, a quarter when the COVID-19 pandemic began; with accelerated declines in April to June 2020 following national lockdown. The trends for the stated services began to increase during July-September 2020, the last quarter of national lockdown. Contraceptive accepters and pentavalent-1 vaccination continued to decline and showed no recovery until January-March 2021 when this study was completed.\n\nMost of the maternal and child health services performance declined following the onset of COVID-19 pandemic and national lockdown, and most of the services began recovering during July-September 2020, the last quarter of national lockdown. However, new and repeat contraceptive accepters and pentavalent-1 recipients continue to decline and show no recovery during end of the study period. Implementing COVID-19 prevention measures and assuring the community about the safety of service delivery is imperative to ensure continuity of the maternal and child health services. Regular monitoring and evaluation of services performance is required to identify slowly recovering services and respond to potentially volatile changes during the COVID-19 pandemic.", "doi": "10.1186/s12978-022-01353-6", "pmid": "35164776", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12978-022-01353-6"}], "notes": [], "created": "2022-02-17T06:08:00.863Z", "modified": "2022-02-17T06:08:11.512Z"}, {"entity": "publication", "iuid": "dae53a9eb16449ce83d40a8d36a3eb42", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dae53a9eb16449ce83d40a8d36a3eb42.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dae53a9eb16449ce83d40a8d36a3eb42"}}, "title": "Conceptual unclarity about COVID-19 ethnic disparities in Sweden: Implications for public health policy.", "authors": [{"family": "Bredstr\u00f6m", "given": "Anna", "initials": "A", "orcid": "0000-0001-5451-8540", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f5a6ad989aa4b82a0ec03e6090c16e1.json"}}, {"family": "Mulinari", "given": "Shai", "initials": "S", "orcid": "0000-0001-8773-9796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/affaf495414d44bca4566f0a37fcaf14.json"}}], "type": "journal article", "published": "2022-02-13", "journal": {"title": "Health (London)", "issn": "1461-7196", "pages": "13634593221074866", "issn-l": null}, "abstract": "The COVID-19 pandemic has shed light on abundant racial and ethnic health disparities in many countries around the world. In Sweden, statistics on COVID-19 mortality and morbidity from both the first and the second wave of the pandemic show that foreign-born individuals have been disproportionately affected, compared to Swedish-born individuals. However, as demonstrated in this article, key stakeholders including politicians, public authorities, mainstream media, and medical researchers do not draw on the same explanatory framework when conceptualizing the health disparity. Probing the different discourses that were articulated through oral and written accounts during the first wave, the article identifies three different frameworks of how ethnic health disparities in relation to COVID-19 were understood in Sweden: the socioeconomic framework, the culturalist framework and the biological framework. We discuss the importance of our findings for health policy and argue for continued interrogation of epidemiological knowledge production from a critical vantage point in order to successfully combat health inequalities.", "doi": "10.1177/13634593221074866", "pmid": "35152788", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-17T06:12:38.880Z", "modified": "2022-02-17T06:12:53.371Z"}, {"entity": "publication", "iuid": "107ba0ee394b4b7bb09b8756dbe17412", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/107ba0ee394b4b7bb09b8756dbe17412.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/107ba0ee394b4b7bb09b8756dbe17412"}}, "title": "Seroprevalence and T-cell response in 32 children 10 months after COVID-19.", "authors": [{"family": "Moritz", "given": "David", "initials": "D"}, {"family": "Krifors", "given": "Anders", "initials": "A"}, {"family": "Freyhult", "given": "Elisabeth", "initials": "E"}, {"family": "M\u00e5nsson", "given": "Emeli", "initials": "E", "orcid": "0000-0003-2867-1044", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b7d5d97f6954001a6e13398e992a01f.json"}}], "type": "journal article", "published": "2022-02-12", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253"}, "abstract": null, "doi": "10.1111/apa.16287", "pmid": "35150457", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Proteins": null}, "xrefs": [], "notes": [], "created": "2022-02-17T06:13:41.574Z", "modified": "2022-02-17T06:13:57.004Z"}, {"entity": "publication", "iuid": "6416fe9ee2414a359e25352a7fd27f1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6416fe9ee2414a359e25352a7fd27f1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6416fe9ee2414a359e25352a7fd27f1d"}}, "title": "Sequential lateral positioning as a new lung recruitment maneuver: an exploratory study in early mechanically ventilated Covid-19 ARDS patients.", "authors": [{"family": "Rold\u00e1n", "given": "Rollin", "initials": "R"}, {"family": "Rodriguez", "given": "Shalim", "initials": "S"}, {"family": "Barriga", "given": "Fernando", "initials": "F"}, {"family": "Tucci", "given": "Mauro", "initials": "M"}, {"family": "Victor", "given": "Marcus", "initials": "M"}, {"family": "Alcala", "given": "Glasiele", "initials": "G"}, {"family": "Villamonte", "given": "Ren\u00e1n", "initials": "R"}, {"family": "Su\u00e1rez-Sipmann", "given": "Fernando", "initials": "F"}, {"family": "Amato", "given": "Marcelo", "initials": "M"}, {"family": "Brochard", "given": "Laurent", "initials": "L"}, {"family": "Tusman", "given": "Gerardo", "initials": "G"}], "type": "journal article", "published": "2022-02-12", "journal": {"title": "Ann Intensive Care", "issn": "2110-5820", "volume": "12", "issue": "1", "pages": "13", "issn-l": null}, "abstract": "A sequential change in body position from supine-to-both lateral positions under constant ventilatory settings could be used as a postural recruitment maneuver in case of acute respiratory distress syndrome (ARDS), provided that sufficient positive end-expiratory pressure (PEEP) prevents derecruitment. This study aims to evaluate the feasibility and physiological effects of a sequential postural recruitment maneuver in early mechanically ventilated COVID-19 ARDS patients.\n\nA cohort of 15 patients receiving lung-protective mechanical ventilation in volume-controlled with PEEP based on recruitability were prospectively enrolled and evaluated in five sequentially applied positions for 30 min each: Supine-baseline; Lateral-1st side; 2nd Supine; Lateral-2nd side; Supine-final. PEEP level was selected using the recruitment-to-inflation ratio (R/I ratio) based on which patients received PEEP 12 cmH2O for R/I ratio \u2264 0.5 or PEEP 15 cmH2O for R/I ratio > 0.5. At the end of each period, we measured respiratory mechanics, arterial blood gases, lung ultrasound aeration, end-expiratory lung impedance (EELI), and regional distribution of ventilation and perfusion using electric impedance tomography (EIT).\n\nComparing supine baseline and final, respiratory compliance (29 \u00b1 9 vs 32 \u00b1 8 mL/cmH2O; p < 0.01) and PaO2/FIO2 ratio (138 \u00b1 36 vs 164 \u00b1 46 mmHg; p < 0.01) increased, while driving pressure (13 \u00b1 2 vs 11 \u00b1 2 cmH2O; p < 0.01) and lung ultrasound consolidation score decreased [5 (4-5) vs 2 (1-4); p < 0.01]. EELI decreased ventrally (218 \u00b1 205 mL; p < 0.01) and increased dorsally (192 \u00b1 475 mL; p = 0.02), while regional compliance increased in both ventral (11.5 \u00b1 0.7 vs 12.9 \u00b1 0.8 mL/cmH2O; p < 0.01) and dorsal regions (17.1 \u00b1 1.8 vs 18.8 \u00b1 1.8 mL/cmH2O; p < 0.01). Dorsal distribution of perfusion increased (64.8 \u00b1 7.3% vs 66.3 \u00b1 7.2%; p = 0.01).\n\nWithout increasing airway pressure, a sequential postural recruitment maneuver improves global and regional respiratory mechanics and gas exchange along with a redistribution of EELI from ventral to dorsal lung areas and less consolidation. Trial registration ClinicalTrials.gov, NCT04475068. Registered 17 July 2020, https://clinicaltrials.gov/ct2/show/NCT04475068.", "doi": "10.1186/s13613-022-00988-9", "pmid": "35150355", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13613-022-00988-9"}, {"db": "ClinicalTrials.gov", "key": "NCT04475068"}], "notes": [], "created": "2022-02-17T06:14:39.349Z", "modified": "2022-02-17T06:14:51.608Z"}, {"entity": "publication", "iuid": "ac88a0f3969e4dfa9f4b2ad6a11fc37f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac88a0f3969e4dfa9f4b2ad6a11fc37f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac88a0f3969e4dfa9f4b2ad6a11fc37f"}}, "title": "Re: Chen Dong, Sung-Lang Chen, and Wen-Wei Sung's Letter to the Editor re: Karin Wel\u00e9n, Ebba Rosendal, Magnus Gissl\u00e9n, et al. A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome: No Evidence of Benefit, Supported by Epidemiology and In Vitro Data. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2021.12.013.", "authors": [{"family": "Welen", "given": "Karin", "initials": "K"}, {"family": "Rosendal", "given": "Ebba", "initials": "E"}, {"family": "Freyhult", "given": "Eva", "initials": "E"}, {"family": "Fors Connolly", "given": "Anne-Marie", "initials": "AM"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "Josefsson", "given": "Andreas", "initials": "A"}], "type": "letter", "published": "2022-02-12", "journal": {"title": "Eur Urol", "issn": "1873-7560", "issn-l": null}, "abstract": null, "doi": "10.1016/j.eururo.2022.02.001", "pmid": "35168845", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0302-2838(22)01605-0"}], "notes": [], "created": "2022-02-17T06:05:27.796Z", "modified": "2022-02-17T06:05:27.801Z"}, {"entity": "publication", "iuid": "572357eb34bb4861a68ac67d1de20fd4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/572357eb34bb4861a68ac67d1de20fd4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/572357eb34bb4861a68ac67d1de20fd4"}}, "title": "Metabolic Rewiring and Serotonin Depletion in Patients with Post-Acute Sequelae of COVID-19.", "authors": [{"family": "Sadlier", "given": "Corinna", "initials": "C"}, {"family": "Albrich", "given": "Werner C", "initials": "WC"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}, {"family": "Lunjani", "given": "Nonhlanhla", "initials": "N"}, {"family": "Horgan", "given": "Mary", "initials": "M"}, {"family": "O'Toole", "given": "Paul W", "initials": "PW"}, {"family": "O'Mahony", "given": "Liam", "initials": "L"}], "type": "letter", "published": "2022-02-12", "journal": {"title": "Allergy", "issn": "1398-9995", "issn-l": "0105-4538"}, "abstract": null, "doi": "10.1111/all.15253", "pmid": "35150456", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-16T12:05:24.492Z", "modified": "2022-02-17T06:14:20.422Z"}, {"entity": "publication", "iuid": "ff5f3b87ac5f4a3c829af53686ae9225", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff5f3b87ac5f4a3c829af53686ae9225.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff5f3b87ac5f4a3c829af53686ae9225"}}, "title": "Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses.", "authors": [{"family": "Luttens", "given": "Andreas", "initials": "A", "orcid": "0000-0003-2915-7901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39b4f3a4039c4b6aa7e34b57cc923b47.json"}}, {"family": "Gullberg", "given": "Hjalmar", "initials": "H"}, {"family": "Abdurakhmanov", "given": "Eldar", "initials": "E"}, {"family": "Vo", "given": "Duy Duc", "initials": "DD"}, {"family": "Akaberi", "given": "Dario", "initials": "D", "orcid": "0000-0002-9595-9796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e5dfb70a38c41eea193ed13916cdf04.json"}}, {"family": "Talibov", "given": "Vladimir O", "initials": "VO"}, {"family": "Nekhotiaeva", "given": "Natalia", "initials": "N"}, {"family": "Vangeel", "given": "Laura", "initials": "L"}, {"family": "De Jonghe", "given": "Steven", "initials": "S", "orcid": "0000-0002-3872-6558", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b101386f055c47448a6c2c0ea91dfdb7.json"}}, {"family": "Jochmans", "given": "Dirk", "initials": "D"}, {"family": "Krambrich", "given": "Janina", "initials": "J"}, {"family": "Tas", "given": "Ali", "initials": "A"}, {"family": "Lundgren", "given": "Bo", "initials": "B"}, {"family": "Gravenfors", "given": "Ylva", "initials": "Y", "orcid": "0000-0001-6025-4908", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d3fad6d5ee52432db8f07099730198fe.json"}}, {"family": "Craig", "given": "Alexander J", "initials": "AJ"}, {"family": "Atilaw", "given": "Yoseph", "initials": "Y"}, {"family": "Sandstr\u00f6m", "given": "Anja", "initials": "A"}, {"family": "Moodie", "given": "Lindon W K", "initials": "LWK", "orcid": "0000-0002-9500-4535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee771ccfee70464cae2a25da0125ae82.json"}}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "van Hemert", "given": "Martijn J", "initials": "MJ"}, {"family": "Neyts", "given": "Johan", "initials": "J"}, {"family": "Lennerstrand", "given": "Johan", "initials": "J"}, {"family": "Kihlberg", "given": "Jan", "initials": "J", "orcid": "0000-0002-4205-6040", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e47b47a621b6402b935364d11e1a640a.json"}}, {"family": "Sandberg", "given": "Kristian", "initials": "K"}, {"family": "Danielson", "given": "U Helena", "initials": "UH", "orcid": "0000-0003-2728-0340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e14a218e8a44c75816b9843d0df3d0e.json"}}, {"family": "Carlsson", "given": "Jens", "initials": "J", "orcid": "0000-0003-4623-2977", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce715411f7d245f0973ab60fe2cd88c8.json"}}], "type": "journal article", "published": "2022-02-10", "journal": {"title": "J Am Chem Soc", "issn": "1520-5126", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Drugs targeting SARS-CoV-2 could have saved millions of lives during the COVID-19 pandemic, and it is now crucial to develop inhibitors of coronavirus replication in preparation for future outbreaks. We explored two virtual screening strategies to find inhibitors of the SARS-CoV-2 main protease in ultralarge chemical libraries. First, structure-based docking was used to screen a diverse library of 235 million virtual compounds against the active site. One hundred top-ranked compounds were tested in binding and enzymatic assays. Second, a fragment discovered by crystallographic screening was optimized guided by docking of millions of elaborated molecules and experimental testing of 93 compounds. Three inhibitors were identified in the first library screen, and five of the selected fragment elaborations showed inhibitory effects. Crystal structures of target-inhibitor complexes confirmed docking predictions and guided hit-to-lead optimization, resulting in a noncovalent main protease inhibitor with nanomolar affinity, a promising in vitro pharmacokinetic profile, and broad-spectrum antiviral effect in infected cells.", "doi": "10.1021/jacs.1c08402", "pmid": "35142215", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Category: Biochemistry": null, "Type: Journal article": null, "Research Area: Pandemic preparedness": null, "Funder: KAW/SciLifeLab": null, "Research Area: Drug discovery and repurposing of drugs": null}, "xrefs": [{"db": "URL", "key": "https://pubs.acs.org/doi/10.1021/jacs.1c08402.", "description": "https://pubs.acs.org/doi/10.1021/jacs.1c08402."}], "notes": [], "created": "2022-02-11T10:20:00.486Z", "modified": "2022-02-11T10:22:04.258Z"}, {"entity": "publication", "iuid": "e6dcf29c4d9547488fef7e7141f960e0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6dcf29c4d9547488fef7e7141f960e0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6dcf29c4d9547488fef7e7141f960e0"}}, "title": "Placental Tissue Destruction and Insufficiency from COVID-19 Causes Stillbirth and Neonatal Death from Hypoxic-Ischemic Injury: A Study of 68 Cases with SARS-CoV-2 Placentitis from 12 Countries.", "authors": [{"family": "Schwartz", "given": "David A", "initials": "DA"}, {"family": "Avvad-Portari", "given": "Elyzabeth", "initials": "E"}, {"family": "Bab\u00e1l", "given": "Pavel", "initials": "P"}, {"family": "Baldewijns", "given": "Marcella", "initials": "M"}, {"family": "Blomberg", "given": "Marie", "initials": "M"}, {"family": "Bouachba", "given": "Amine", "initials": "A"}, {"family": "Camacho", "given": "Jessica", "initials": "J"}, {"family": "Collardeau-Frachon", "given": "Sophie", "initials": "S"}, {"family": "Colson", "given": "Arthur", "initials": "A"}, {"family": "Dehaene", "given": "Isabelle", "initials": "I"}, {"family": "Ferreres", "given": "Joan Carles", "initials": "JC"}, {"family": "Fitzgerald", "given": "Brendan", "initials": "B"}, {"family": "Garrido-Pontnou", "given": "Marta", "initials": "M"}, {"family": "Gerges", "given": "Hazem", "initials": "H"}, {"family": "Hargitai", "given": "Beata", "initials": "B"}, {"family": "Helguera-Repetto", "given": "A Cecilia", "initials": "AC"}, {"family": "Holmstr\u00f6m", "given": "Sandra", "initials": "S"}, {"family": "Irles", "given": "Claudine Liliane", "initials": "CL"}, {"family": "Leijonhfvud", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Libbrecht", "given": "Sasha", "initials": "S"}, {"family": "Marton", "given": "Tam\u00e1s", "initials": "T"}, {"family": "McEntagart", "given": "Noel", "initials": "N"}, {"family": "Molina", "given": "James T", "initials": "JT"}, {"family": "Morotti", "given": "Raffaella", "initials": "R"}, {"family": "Nadal", "given": "Alfons", "initials": "A"}, {"family": "Navarro", "given": "Alexandra", "initials": "A"}, {"family": "Nelander", "given": "Maria", "initials": "M"}, {"family": "Oviedo", "given": "Angelica", "initials": "A"}, {"family": "Oyamada Otani", "given": "Andre Ricardo", "initials": "AR"}, {"family": "Papadogiannakis", "given": "Nikos", "initials": "N"}, {"family": "Petersen", "given": "Astrid C", "initials": "AC"}, {"family": "Roberts", "given": "Drucilla J", "initials": "DJ"}, {"family": "Saad", "given": "Ali G", "initials": "AG"}, {"family": "Sand", "given": "Anna", "initials": "A"}, {"family": "Schoenmakers", "given": "Sam", "initials": "S"}, {"family": "Sehn", "given": "Jennifer K", "initials": "JK"}, {"family": "Simpson", "given": "Preston R", "initials": "PR"}, {"family": "Thomas", "given": "Kristen", "initials": "K"}, {"family": "Valdespino-V\u00e1zquez", "given": "M Yolotzin", "initials": "MY"}, {"family": "van der Meeren", "given": "Lotte E", "initials": "LE"}, {"family": "Van Dorpe", "given": "Jo", "initials": "J"}, {"family": "Verdijk", "given": "Robert M", "initials": "RM"}, {"family": "Watkins", "given": "Jaclyn C", "initials": "JC"}, {"family": "Zaigham", "given": "Mehreen", "initials": "M"}], "type": "journal article", "published": "2022-02-10", "journal": {"title": "Arch Pathol Lab Med", "issn": "1543-2165", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Perinatal death is an increasingly important problem as the COVID-19 pandemic continues, but the mechanism of death has been unclear.\n\nTo evaluate the role of the placenta in causing stillbirth and neonatal death following maternal infection with COVID-19 and confirmed placental positivity for SARS-CoV-2.\n\nCase-based retrospective clinico-pathological analysis by a multinational group of 44 perinatal specialists from 12 countries of placental and autopsy pathology findings from 64 stillborns and 4 neonatal deaths having placentas testing positive for SARS-CoV-2 following delivery to mothers with COVID-19.\n\nAll 68 placentas had increased fibrin deposition and villous trophoblast necrosis and 66 had chronic histiocytic intervillositis, the three findings constituting SARS-CoV-2 placentitis. Sixty-three placentas had massive perivillous fibrin deposition. Severe destructive placental disease from SARS-CoV-2 placentitis averaged 77.7% tissue involvement. Other findings included multiple intervillous thrombi (37%; 25/68) and chronic villitis (32%; 22/68). The majority (19, 63%) of the 30 autopsies revealed no significant fetal abnormalities except for intrauterine hypoxia and asphyxia. Among all 68 cases, SARS-CoV-2 was detected from a body specimen in 16 of 28 cases tested, most frequently from nasopharyngeal swabs. Four autopsied stillborns had SARS-CoV-2 identified in internal organs.\n\nThe pathology abnormalities composing SARS-CoV-2 placentitis cause widespread and severe placental destruction resulting in placental malperfusion and insufficiency. In these cases, intrauterine and perinatal death likely results directly from placental insufficiency and fetal hypoxic-ischemic injury. There was no evidence that SARS-CoV-2 involvement of the fetus had a role in causing these deaths.", "doi": "10.5858/arpa.2022-0029-SA", "pmid": "35142798", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "477699"}], "notes": [], "created": "2022-02-11T10:15:45.874Z", "modified": "2022-02-17T06:16:40.734Z"}, {"entity": "publication", "iuid": "09663934bf94465288397f7dc679f5d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/09663934bf94465288397f7dc679f5d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/09663934bf94465288397f7dc679f5d0"}}, "title": "Broad anti-SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1/mRNA-1273 vaccination.", "authors": [{"family": "Kaku", "given": "Chengzi I", "initials": "CI", "orcid": "0000-0002-9854-8351", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be56dead52324203a9b37fc32f23626f.json"}}, {"family": "Champney", "given": "Elizabeth R", "initials": "ER"}, {"family": "Normark", "given": "Johan", "initials": "J", "orcid": "0000-0001-5831-4369", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cab4f084027e4e4b8f0e5113a499e5c6.json"}}, {"family": "Garcia", "given": "Marina", "initials": "M", "orcid": "0000-0002-9130-3933", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5b109d7a54e4c05a48e0f21c4432be6.json"}}, {"family": "Johnson", "given": "Carl E", "initials": "CE"}, {"family": "Ahlm", "given": "Clas", "initials": "C", "orcid": "0000-0003-2018-8592", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/833d0293b5d74bbabec63e922cd19d54.json"}}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f2dc27d02294a15a6f691be6aab641f.json"}}, {"family": "Sakharkar", "given": "Mrunal", "initials": "M", "orcid": "0000-0002-2717-5201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2694a69ce874c3f93cf4f9ed8d736dd.json"}}, {"family": "Ackerman", "given": "Margaret E", "initials": "ME", "orcid": "0000-0002-4253-3476", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10fea712c93441dd922bbcb531b46148.json"}}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE", "orcid": "0000-0001-6904-742X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e41c0e1c9c7b499fb3d844d4c572e7bb.json"}}, {"family": "Walker", "given": "Laura M", "initials": "LM", "orcid": "0000-0001-7704-3197", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a40fc6cfefc14436a12cc467c3cacd54.json"}}], "type": "journal article", "published": "2022-02-10", "journal": {"title": "Science", "issn": "1095-9203", "pages": "eabn2688", "issn-l": "0036-8075"}, "abstract": "Heterologous prime-boost immunization strategies have the potential to augment COVID-19 vaccine efficacy. We longitudinally profiled SARS-CoV-2 spike (S)-specific serological and memory B cell (MBC) responses in individuals receiving either homologous (ChAdOx1:ChAdOx1) or heterologous (ChAdOx1:mRNA-1273) prime-boost vaccination. Heterologous mRNA booster immunization induced higher serum neutralizing antibody and MBC responses against SARS-CoV-2 variants of concern (VOCs) compared to homologous ChAdOx1 boosting. Specificity mapping of circulating B cells revealed that mRNA-1273 boost immunofocused ChAdOx1-primed responses onto epitopes expressed on prefusion-stabilized S. Monoclonal antibodies isolated from mRNA-1273 boosted participants displayed overall higher binding affinities and increased breadth of reactivity against VOCs relative to those isolated from ChAdOx1-boosted individuals. Overall, the results provide molecular insight into the enhanced quality of the B cell response induced following heterologous mRNA booster vaccination.", "doi": "10.1126/science.abn2688", "pmid": "35143256", "labels": {"Category: Health": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-11T10:17:32.493Z", "modified": "2022-02-17T06:16:08.848Z"}, {"entity": "publication", "iuid": "bcdfcb32836f42e8b943b15ad2dd61a5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bcdfcb32836f42e8b943b15ad2dd61a5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bcdfcb32836f42e8b943b15ad2dd61a5"}}, "title": "Whole genome analysis and homology modeling of SARS-CoV-2 Indian isolate reveals potent FDA approved drug choice for treating COVID-19.", "authors": [{"family": "Velu", "given": "Periyannan", "initials": "P"}, {"family": "Rathinavel", "given": "Thirumalaisamy", "initials": "T", "orcid": "0000-0003-3137-5895", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25f33e7fd0634e568735a3641d573ef8.json"}}, {"family": "Kumarasamy", "given": "Suresh", "initials": "S", "orcid": "0000-0002-4931-7274", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c46cd8b2ab848aca02e70a5e1f12cd8.json"}}, {"family": "Iqbal", "given": "Muhammad Nasir", "initials": "MN", "orcid": "0000-0002-8875-8400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e141277ae6474ac2a3e1f17d1617834d.json"}}, {"family": "Noor", "given": "Hasnat", "initials": "H"}, {"family": "Ikram", "given": "Ayesha", "initials": "A"}, {"family": "Rajamanickam", "given": "Karthika", "initials": "K"}, {"family": "Shanmugam", "given": "Gnanendra", "initials": "G"}], "type": "journal article", "published": "2022-02-09", "journal": {"title": "J Biomol Struct Dyn", "issn": "1538-0254", "pages": "1-17", "issn-l": null}, "abstract": "Coronaviruses have caused enough devastation in the last two decades. These viruses have some rare features while sharing some common features. Novel coronavirus disease (nCoV-19) caused an outbreak with a fatality rate of 5%. It emerged from China and spread into many countries. The present research focused on genome analysis of Indian nCoV-19 Isolate and its translational product subjected to homology modeling and its subsequent molecular simulations to find out potent FDA approved drug for treating COVID-19. Phylogenetic analysis of SARS-CoV-2 Indian isolate shows close resemblance with 17 countries SARS-CoV-2 isolates. Homology modeling of four non-structural proteins translational product of Indian SARS-CoV-2 genome shows high similarity and allowed regions with the existing PDB deposited SARS-CoV-2 target proteins. Finally, these four generated proteins show more affinity with cobicistat, remdesivir and indinavir out of 14 screened FDA approved drugs in molecular docking which is further proven by molecular dynamics simulation and MMGBSA analysis of target ligand complex with best simulation trajectories. Overall our present research findings is that three proposed drugs namely cobicistat, remdesivir and indinavir showed higher interaction with the model SARS-CoV-2 viral target proteins from the Indian nCoV-19 isolate. These compounds could be used as a starting point for the creation of active antiviral drugs to combat the deadly COVID-19 virus during global pandemic and its subsequent viral infection waves across the globe.Communicated by Ramaswamy H. Sarma.", "doi": "10.1080/07391102.2022.2038272", "pmid": "35139758", "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-11T10:24:41.199Z", "modified": "2022-02-11T10:24:41.351Z"}, {"entity": "publication", "iuid": "d7a6ecface78453e933adb93c529d4ea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d7a6ecface78453e933adb93c529d4ea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d7a6ecface78453e933adb93c529d4ea"}}, "title": "The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury: State-of-the-Art Review.", "authors": [{"family": "Siripanthong", "given": "Bhurint", "initials": "B"}, {"family": "Asatryan", "given": "Babken", "initials": "B"}, {"family": "Hanff", "given": "Thomas C", "initials": "TC"}, {"family": "Chatha", "given": "Salman R", "initials": "SR"}, {"family": "Khanji", "given": "Mohammed Y", "initials": "MY"}, {"family": "Ricci", "given": "Fabrizio", "initials": "F"}, {"family": "Muser", "given": "Daniele", "initials": "D"}, {"family": "Ferrari", "given": "Victor A", "initials": "VA"}, {"family": "Nazarian", "given": "Saman", "initials": "S"}, {"family": "Santangeli", "given": "Pasquale", "initials": "P"}, {"family": "Deo", "given": "Rajat", "initials": "R"}, {"family": "Cooper", "given": "Leslie T", "initials": "LT"}, {"family": "Mohiddin", "given": "Saidi A", "initials": "SA"}, {"family": "Chahal", "given": "C Anwar A", "initials": "CAA"}], "type": "journal article", "published": "2022-02-09", "journal": {"title": "JACC Basic Transl Sci", "issn": "2452-302X", "issn-l": null}, "abstract": "The mechanisms of coronavirus disease 2019 (COVID-19)-related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity.", "doi": "10.1016/j.jacbts.2021.10.011", "pmid": "35165665", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2452-302X(21)00318-1"}, {"db": "pmc", "key": "PMC8828362"}], "notes": [], "created": "2022-02-17T06:06:45.486Z", "modified": "2022-02-17T06:06:45.521Z"}, {"entity": "publication", "iuid": "7616f43c137c4aa59370f1f07a770009", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7616f43c137c4aa59370f1f07a770009.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7616f43c137c4aa59370f1f07a770009"}}, "title": "Little support for a protective effect of ADT against COVID-19.", "authors": [{"family": "Josefsson", "given": "Andreas", "initials": "A", "orcid": "0000-0002-2013-0887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1ba4bf5497b4c6e9334948925e3be76.json"}}], "type": "editorial", "published": "2022-02-09", "journal": {"title": "Scand J Urol", "issn": "2168-1813", "issn-l": null, "volume": null, "issue": null, "pages": "1-2"}, "abstract": null, "doi": "10.1080/21681805.2022.2033313", "pmid": "35137649", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-11T10:24:56.477Z", "modified": "2022-02-11T10:25:30.715Z"}, {"entity": "publication", "iuid": "7673dbe3bac44bc5a6299833d4d3d98d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7673dbe3bac44bc5a6299833d4d3d98d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7673dbe3bac44bc5a6299833d4d3d98d"}}, "title": "Intimate physical contact between people from different households during the COVID-19 pandemic: a mixed-methods study from a large, quasi-representative survey (Natsal-COVID).", "authors": [{"family": "Sonnenberg", "given": "Pam", "initials": "P", "orcid": "0000-0002-1067-1583", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/703eb395b191407eb977ed908453cb30.json"}}, {"family": "Menezes", "given": "Dee", "initials": "D", "orcid": "0000-0002-1628-1228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7babe7d1c2694f6aadde9c1de8ed74be.json"}}, {"family": "Freeman", "given": "Lily", "initials": "L"}, {"family": "Maxwell", "given": "Karen J", "initials": "KJ", "orcid": "0000-0002-2264-6510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43d1a00df778443d880fac4894e93630.json"}}, {"family": "Reid", "given": "David", "initials": "D", "orcid": "0000-0001-6832-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9650baded4724b0fb749dbfea43e1632.json"}}, {"family": "Clifton", "given": "Soazig", "initials": "S", "orcid": "0000-0002-4171-0805", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7cea96a2c56409dab9f474144303c30.json"}}, {"family": "Tanton", "given": "Clare", "initials": "C", "orcid": "0000-0002-4612-1858", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adf2ed41e93f422aa32a1afe93895bed.json"}}, {"family": "Copas", "given": "Andrew", "initials": "A", "orcid": "0000-0001-8968-5963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0aee9dde1bb2497398a63252a713c88a.json"}}, {"family": "Riddell", "given": "Julie", "initials": "J", "orcid": "0000-0002-8084-4566", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9660f5597db42d19462b83c9f8a1be4.json"}}, {"family": "Dema", "given": "Emily", "initials": "E", "orcid": "0000-0002-7254-2023", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3843a1be6fc4e37ac3f8eeff9a2bbb2.json"}}, {"family": "Bos\u00f3 P\u00e9rez", "given": "Raquel", "initials": "R", "orcid": "0000-0001-7342-4566", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3d61e70a5874b4ea43a1d9d73333605.json"}}, {"family": "Gibbs", "given": "Jo", "initials": "J", "orcid": "0000-0001-5696-0260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8e88ce8b71e4ae3b03749616b5a9eab.json"}}, {"family": "Ridge", "given": "Mary-Clare", "initials": "MC", "orcid": "0000-0001-9621-4529", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fda16e5b838e4da895af4b74f233e246.json"}}, {"family": "Macdowall", "given": "Wendy", "initials": "W", "orcid": "0000-0001-5868-8336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3cfc1c64d9b84957a244f64c09b483bf.json"}}, {"family": "Unemo", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1710-2081", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed8c616c8c16456590342443393553cb.json"}}, {"family": "Bonell", "given": "Chris", "initials": "C", "orcid": "0000-0002-6253-6498", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eeec7c46459414a974c9f42cc3b2baa.json"}}, {"family": "Johnson", "given": "Anne M", "initials": "AM", "orcid": "0000-0003-1330-7100", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f878d2115174a69a8de743cc40b6a15.json"}}, {"family": "Mercer", "given": "Catherine H", "initials": "CH", "orcid": "0000-0002-4220-5034", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6332e0448a8b49c7ab019b7c75768df1.json"}}, {"family": "Mitchell", "given": "Kirstin", "initials": "K", "orcid": "0000-0002-4409-6601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2af6a4b606314786806e669e86b92ee0.json"}}, {"family": "Field", "given": "Nigel", "initials": "N", "orcid": "0000-0002-2825-6652", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a84330facf864cfe9a4a51550cea9543.json"}}], "type": "journal article", "published": "2022-02-09", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "2", "pages": "e055284", "issn-l": "2044-6055"}, "abstract": "Physical distancing as a non-pharmaceutical intervention aims to reduce interactions between people to prevent SARS-CoV-2 transmission. Intimate physical contact outside the household (IPCOH) may expand transmission networks by connecting households. We aimed to explore whether intimacy needs impacted adherence to physical distancing following lockdown in Britain in March 2020.\n\nThe Natsal-COVID web-panel survey (July-August 2020) used quota-sampling and weighting to achieve a quasi-representative population sample. We estimate reporting of IPCOH with a romantic/sexual partner in the 4 weeks prior to interview, describe the type of contact, identify demographic and behavioural factors associated with IPCOH and present age-adjusted ORs (aORs). Qualitative interviews (n=18) were conducted to understand the context, reasons and decision making around IPCOH.\n\nOf 6654 participants aged 18-59 years, 9.9% (95% CI 9.1% to 10.6%) reported IPCOH. IPCOH was highest in those aged 18-24 (17.7%), identifying as gay or lesbian (19.5%), and in steady non-cohabiting relationships (56.3%). IPCOH was associated with reporting risk behaviours (eg, condomless sex, higher alcohol consumption). IPCOH was less likely among those reporting bad/very bad health (aOR 0.54; 95% CI 0.32 to 0.93) but more likely among those with COVID-19 symptoms and/or diagnosis (aOR 1.34; 95% CI 1.10 to 1.65). Two-thirds (64.4%) of IPCOH was reported as being within a support bubble. Qualitative interviews found that people reporting IPCOH deliberated over, and made efforts to mitigate, the risks.\n\nGiven 90% of people did not report IPCOH, this contact may not be a large additional contributor to SARS-CoV-2 transmission, although heterogeneity exists within the population. Public health messages need to recognise how single people and partners living apart balance sexual intimacy and relationship needs with adherence to control measures.", "doi": "10.1136/bmjopen-2021-055284", "pmid": "35140158", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-055284"}], "notes": [], "created": "2022-02-11T10:24:02.508Z", "modified": "2022-02-11T10:24:19.538Z"}, {"entity": "publication", "iuid": "6b2601546e12410eb50fc403016bf292", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b2601546e12410eb50fc403016bf292.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b2601546e12410eb50fc403016bf292"}}, "title": "Working conditions in primary healthcare during the COVID-19 pandemic: an interview study with physicians in Sweden.", "authors": [{"family": "Fernemark", "given": "Hanna", "initials": "H", "orcid": "0000-0002-9029-4406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0cd7e6f1012a4ff08bf13b0a17385bfd.json"}}, {"family": "Skagerstr\u00f6m", "given": "Janna", "initials": "J"}, {"family": "Seing", "given": "Ida", "initials": "I"}, {"family": "H\u00e5rdstedt", "given": "Maria", "initials": "M"}, {"family": "Schildmeijer", "given": "Kristina", "initials": "K", "orcid": "0000-0002-0895-674X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05115c15c6834224851474c2635ded5d.json"}}, {"family": "Nilsen", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2022-02-08", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "2", "pages": "e055035", "issn-l": "2044-6055"}, "abstract": "The aim of this study was to explore how the COVID-19 pandemic changed the working conditions of physicians in Swedish primary healthcare.\n\nThis is a descriptive, qualitative study with individual semistructured interviews. Data were analysed using inductive content analysis.\n\nSwedish primary healthcare units in both rural and urban areas.\n\nA total of 11 primary care physicians fulfilled participation.\n\nTwo main categories emerged: 'work organisation and routines' and 'psychosocial work environment', containing three and five subcategories, respectively. The pandemic enforced changes in work organisation and routines. Increased flexibility, including more patient-oriented delivery of care, and novel means of interorganisational and intraorganisational interactions were perceived as positive by physicians. The pandemic also caused several changes in physicians' psychosocial work environment. Increased workload, information overload, as well as ethical considerations and feelings of uncertainty made the work environment stressful for physicians.\n\nThe COVID-19 pandemic affected the working conditions of physicians in Swedish primary healthcare in numerous ways. The pandemic enforced changes in work organisation and routines for physicians in primary healthcare. Further research is needed to investigate how the pandemic will affect primary healthcare in the longer term. Learning from the pandemic is important because this will not be the last crisis that primary care and its healthcare professionals will face.", "doi": "10.1136/bmjopen-2021-055035", "pmid": "35135771", "labels": {"Category: Public Health": null, "Type: Review": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC8829841"}, {"db": "pii", "key": "bmjopen-2021-055035"}], "notes": [], "created": "2022-02-11T10:35:46.204Z", "modified": "2023-01-13T14:47:38.535Z"}, {"entity": "publication", "iuid": "b84fe457b9754ffea8e728b51a1124de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b84fe457b9754ffea8e728b51a1124de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b84fe457b9754ffea8e728b51a1124de"}}, "title": "Reduced dispensing of prescribed antibiotics during the Covid-19 pandemic has not increased severe complications from common infections.", "authors": [{"family": "Norman", "given": "Christer", "initials": "C"}, {"family": "Svensson", "given": "Mikaela", "initials": "M"}, {"family": "Schmidt", "given": "Ingrid", "initials": "I"}, {"family": "Bergfeldt", "given": "Vendela S", "initials": "VS"}, {"family": "Obeid", "given": "Ragda", "initials": "R"}, {"family": "Ternhag", "given": "Anders", "initials": "A"}, {"family": "Struwe", "given": "Johan L", "initials": "JL"}], "type": "journal article", "published": "2022-02-08", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "252", "issn-l": null}, "abstract": "Sweden has seen an accelerated decline in the number of dispensed antibiotic prescriptions from an already low level during the Covid-19 pandemic. This prompted us to explore whether the decrease in antibiotic prescriptions has reached a critically low level and resulted in an increase in treatment of severe complications from common infections. The aim was to study if the accelerated decrease in antibiotic sales has led to an increase in complications in outpatients with common infections.\n\nA population-based nationwide registry study based on the Swedish Prescribed Drug Register and the National Patient Register.\n\nThe total number of dispensed antibiotic prescriptions decreased by 17% during 2020 compared to 2019. The decrease was most pronounced in younger age groups and for antibiotics targeting respiratory tract infections. The number of hospital admissions and visits to open specialist care due to pneumonia or complications related to otitis, tonsillitis, or sinusitis decreased by 4-44%. Prescriptions and numbers of visits or admissions due to urinary tract infections and skin infections remained largely unchanged compared to previous years.\n\nNo increase in complications due to common bacterial infections could be detected despite an unprecedented decline in dispensed antibiotic prescriptions in outpatient care in 2020. The decrease in dispensed antibiotic prescriptions from pharmacies was probably primarily related to a general decrease in the incidence of respiratory infections due to the recommendations and restrictions implemented to mitigate the Covid-19 pandemic in Sweden. This in return led to fewer doctors' visits and consequently to fewer occasions to prescribe antibiotics, be they warranted or not.", "doi": "10.1186/s12889-022-12692-1", "pmid": "35135517", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-022-12692-1"}], "notes": [], "created": "2022-02-11T10:36:04.989Z", "modified": "2022-02-11T10:36:05.002Z"}, {"entity": "publication", "iuid": "b80e10297ec44011b4e0af10c4361471", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b80e10297ec44011b4e0af10c4361471.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b80e10297ec44011b4e0af10c4361471"}}, "title": "NK cell frequencies, function and correlates to vaccine outcome in BNT162b2 mRNA anti-SARS-CoV-2 vaccinated healthy and immunocompromised individuals.", "authors": [{"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Boulouis", "given": "Caroline", "initials": "C"}, {"family": "Filipovic", "given": "Iva", "initials": "I"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Kammann", "given": "Tobias", "initials": "T"}, {"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Hammer", "given": "Quirin", "initials": "Q"}, {"family": "Strunz", "given": "Benedikt", "initials": "B"}, {"family": "P\u00e9rez Potti", "given": "Andr\u00e9", "initials": "A"}, {"family": "Rivera Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Lange", "given": "Joshua", "initials": "J"}, {"family": "Muvva", "given": "Jagadeeswara Rao", "initials": "JR"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Mielke", "given": "Stephan", "initials": "S"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "S\u00f6derdahl", "given": "Gunnar", "initials": "G"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "Sobkowiak", "given": "Michal J", "initials": "MJ"}, {"family": "Gabarrini", "given": "Giorgio", "initials": "G"}, {"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M"}, {"family": "Alici", "given": "Evren", "initials": "E"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG", "orcid": "0000-0003-0908-7387", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48a59f01e46c41038301a586178e8e2a.json"}}], "type": "journal article", "published": "2022-02-08", "journal": {"title": "Mol Med", "issn": "1528-3658", "volume": "28", "issue": "1", "pages": "20", "issn-l": "1076-1551"}, "abstract": "Adaptive immune responses have been studied extensively in the course of mRNA vaccination against COVID-19. Considerably fewer studies have assessed the effects on innate immune cells. Here, we characterized NK cells in healthy individuals and immunocompromised patients in the course of an anti-SARS-CoV-2 BNT162b2 mRNA prospective, open-label clinical vaccine trial. See trial registration description in notes. Results revealed preserved NK cell numbers, frequencies, subsets, phenotypes, and function as assessed through consecutive peripheral blood samplings at 0, 10, 21, and 35 days following vaccination. A positive correlation was observed between the frequency of NKG2C+ NK cells at baseline (Day 0) and anti-SARS-CoV-2 Ab titers following BNT162b2 mRNA vaccination at Day 35. The present results provide basic insights in regards to NK cells in the context of mRNA vaccination, and have relevance for future mRNA-based vaccinations against COVID-19, other viral infections, and cancer.Trial registration: The current study is based on clinical material from the COVAXID open-label, non-randomized prospective clinical trial registered at EudraCT and clinicaltrials.gov (no. 2021-000175-37). Description: https://clinicaltrials.gov/ct2/show/NCT04780659?term=2021-000175-37&draw=2&rank=1 .", "doi": "10.1186/s10020-022-00443-2", "pmid": "35135470", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null, "Research Area: Vaccine": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "10.1186/s10020-022-00443-2"}, {"db": "ClinicalTrials.gov", "key": "NCT04780659"}], "notes": [], "created": "2022-02-11T10:36:36.455Z", "modified": "2022-02-11T10:37:25.339Z"}, {"entity": "publication", "iuid": "63a75994008f423d81539733ef3c83dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63a75994008f423d81539733ef3c83dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63a75994008f423d81539733ef3c83dd"}}, "title": "Levels and Correlates of Objectively Measured Sedentary Behaviour in Young Children: SUNRISE Study Results from 19 Countries.", "authors": [{"family": "Kariippanon", "given": "Katharina E", "initials": "KE"}, {"family": "Chong", "given": "Kar Hau", "initials": "KH"}, {"family": "Janssen", "given": "Xanne", "initials": "X"}, {"family": "Tomaz", "given": "Simone A", "initials": "SA"}, {"family": "Ribeiro", "given": "Evelyn Hc", "initials": "EH"}, {"family": "Munambah", "given": "Nyaradzai", "initials": "N"}, {"family": "Chan", "given": "Cecilia Hs", "initials": "CH"}, {"family": "Chathurangana", "given": "P W Prasad", "initials": "PWP"}, {"family": "Draper", "given": "Catherine E", "initials": "CE"}, {"family": "El Hamdouchi", "given": "Asmaa", "initials": "A"}, {"family": "Florindo", "given": "Alex A", "initials": "AA"}, {"family": "Guan", "given": "Hongyan", "initials": "H"}, {"family": "Ha", "given": "Amy S", "initials": "AS"}, {"family": "Hossain", "given": "Mohammad Sorowar", "initials": "MS"}, {"family": "Kim", "given": "Dong Hoon", "initials": "DH"}, {"family": "Van Kim", "given": "Thanh", "initials": "T"}, {"family": "Koh", "given": "Denise Cl", "initials": "DC"}, {"family": "L\u00f6f", "given": "Marie", "initials": "M"}, {"family": "Pham", "given": "Bang Nguyen", "initials": "BN"}, {"family": "Poh", "given": "Bee Koon", "initials": "BK"}, {"family": "Reilly", "given": "John J", "initials": "JJ"}, {"family": "Staiano", "given": "Amanda E", "initials": "AE"}, {"family": "Suherman", "given": "Adang", "initials": "A"}, {"family": "Tanaka", "given": "Chiaki", "initials": "C"}, {"family": "Tang", "given": "Hong Kim", "initials": "HK"}, {"family": "Tremblay", "given": "Mark S", "initials": "MS"}, {"family": "Webster", "given": "E Kipling", "initials": "EK"}, {"family": "Wickramasinghe", "given": "V Pujitha", "initials": "VP"}, {"family": "Wong", "given": "Jyh Eiin", "initials": "JE"}, {"family": "Okely", "given": "Anthony D", "initials": "AD"}], "type": "journal article", "published": "2022-02-08", "journal": {"title": "Med Sci Sports Exerc", "issn": "1530-0315", "issn-l": null}, "abstract": "There is a paucity of global data on sedentary behaviour during early childhood. The purpose of this study was to examine how device-measured sedentary behaviour in young children differed across geographically, economically, and socio-demographically diverse populations, in an international sample.\n\nThis multinational, cross-sectional study included data from 1071 3-5-year-old children from 19 countries, collected between 2018 and 2020 (pre-COVID). Sedentary behaviour was measured for three consecutive days using activPAL accelerometers. Sedentary time, sedentary fragmentation and seated transport duration were calculated. Linear mixed models were used to examine the differences in sedentary behaviour variables between sex, country-level income groups, urban/rural settings, and population density.\n\nChildren spent 56% (7.4 hours) of their waking time sedentary. The longest average bout duration was 81.1 \u00b1 45.4 min, and an average of 61.1 \u00b1 50.1 min/day was spent in seated transport. Children from upper-middle-income and high-income countries spent a greater proportion of the day sedentary, accrued more sedentary bouts, had shorter breaks between sedentary bouts, and spent significantly more time in seated transport, than children from low-and lower-middle-income countries. Sex and urban/rural residential setting were not associated with any outcomes. Higher population density was associated with several higher sedentary behaviour measures.\n\nThese data advance our understanding of young children's sedentary behaviour patterns globally. Country income levels and population density appear to be stronger drivers of the observed differences, than sex or rural/urban residential setting.", "doi": "10.1249/MSS.0000000000002886", "pmid": "35142711", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "00005768-900000000-95866"}], "notes": [], "created": "2022-02-11T10:18:27.153Z", "modified": "2022-02-11T10:19:36.106Z"}, {"entity": "publication", "iuid": "9932239cb6834b7085d7a0157811c4ab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9932239cb6834b7085d7a0157811c4ab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9932239cb6834b7085d7a0157811c4ab"}}, "title": "Impact of ADAR-induced editing of minor viral RNA populations on replication and transmission of SARS-CoV-2.", "authors": [{"family": "Ringlander", "given": "Johan", "initials": "J", "orcid": "0000-0002-8483-6504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64f85af7dceb436498422e62f1a98c89.json"}}, {"family": "Fingal", "given": "Joshua", "initials": "J", "orcid": "0000-0001-7305-1026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6f14cbba252f4dbc8521a654ee524919.json"}}, {"family": "Kann", "given": "Hanna", "initials": "H", "orcid": "0000-0003-2014-5437", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01fe861a1bdb43e3a1128c4e53c0c757.json"}}, {"family": "Prakash", "given": "Kasthuri", "initials": "K", "orcid": "0000-0002-7454-6802", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3dddc60b620149019a0be56cf5963d2a.json"}}, {"family": "Rydell", "given": "Gustaf", "initials": "G", "orcid": "0000-0001-8093-2251", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83098d13393c48f0bd17864bac898c3e.json"}}, {"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Martner", "given": "Anna", "initials": "A", "orcid": "0000-0002-6598-5221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c11a2e719c534772a129782bfb60d35c.json"}}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Horal", "given": "Peter", "initials": "P"}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K"}, {"family": "Kann", "given": "Michael", "initials": "M", "orcid": "0000-0002-9589-8022", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7f54042fa8e49d6a7580a8059eaf6e8.json"}}], "type": "journal article", "published": "2022-02-08", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "119", "issue": "6", "issn-l": "0027-8424"}, "abstract": "Adenosine deaminases acting on RNA (ADAR) are RNA-editing enzymes that may restrict viral infection. We have utilized deep sequencing to determine adenosine to guanine (A\u2192G) mutations, signifying ADAR activity, in clinical samples retrieved from 93 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients in the early phase of the COVID-19 pandemic. A\u2192G mutations were detected in 0.035% (median) of RNA residues and were predominantly nonsynonymous. These mutations were rarely detected in the major viral population but were abundant in minor viral populations in which A\u2192G was more prevalent than any other mutation (P < 0.001). The A\u2192G substitutions accumulated in the spike protein gene at positions corresponding to amino acids 505 to 510 in the receptor binding motif and at amino acids 650 to 655. The frequency of A\u2192G mutations in minor viral populations was significantly associated with low viral load (P < 0.001). We additionally analyzed A\u2192G mutations in 288,247 SARS-CoV-2 major (consensus) sequences representing the dominant viral population. The A\u2192G mutations observed in minor viral populations in the initial patient cohort were increasingly detected in European consensus sequences between March and June 2020 (P < 0.001) followed by a decline of these mutations in autumn and early winter (P < 0.001). We propose that ADAR-induced deamination of RNA is a significant source of mutated SARS-CoV-2 and hypothesize that the degree of RNA deamination may determine or reflect viral fitness and infectivity.", "doi": "10.1073/pnas.2112663119", "pmid": "35064076", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2112663119"}], "notes": [], "created": "2022-01-26T10:18:08.767Z", "modified": "2022-01-26T10:18:24.353Z"}, {"entity": "publication", "iuid": "503b3407b0e04a9caad1fea91b464a61", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/503b3407b0e04a9caad1fea91b464a61.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/503b3407b0e04a9caad1fea91b464a61"}}, "title": "Ventilation is not Depressed in Hypoxemic Patients with Acute COVID-19 Infection.", "authors": [{"family": "Kairaitis", "given": "Kristina", "initials": "K", "orcid": "0000-0002-8808-3183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3ae5783acd74a84a18d6725d96088ab.json"}}, {"family": "Harbut", "given": "Piotr", "initials": "P"}, {"family": "Hedenstierna", "given": "Goran", "initials": "G"}, {"family": "Prisk", "given": "G Kim", "initials": "GK"}, {"family": "Farrow", "given": "Catherine E", "initials": "CE"}, {"family": "Amis", "given": "Terence", "initials": "T"}, {"family": "Wagner", "given": "Peter D", "initials": "PD"}, {"family": "Malhotra", "given": "Atul", "initials": "A"}], "type": "journal article", "published": "2022-02-07", "journal": {"title": "Am J Respir Crit Care Med", "issn": "1535-4970", "issn-l": "1073-449X"}, "abstract": null, "doi": "10.1164/rccm.202109-2025LE", "pmid": "35130468", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-08T15:11:07.236Z", "modified": "2022-02-08T15:11:07.289Z"}, {"entity": "publication", "iuid": "4efe1b00c2b046248a5c147fc8aa7401", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4efe1b00c2b046248a5c147fc8aa7401.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4efe1b00c2b046248a5c147fc8aa7401"}}, "title": "The presence of serum anti-SARS-CoV-2 IgA appears to protect primary health care workers from COVID-19.", "authors": [{"family": "Hennings", "given": "Viktoria", "initials": "V", "orcid": "0000-0002-7789-8299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0111566cc8d64377a863765d0f8efa19.json"}}, {"family": "Th\u00f6rn", "given": "Karolina", "initials": "K"}, {"family": "Albinsson", "given": "Sofie", "initials": "S", "orcid": "0000-0003-2038-4286", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f8e41ce25d544cba35b78ddad3352d9.json"}}, {"family": "Lingblom", "given": "Christine", "initials": "C", "orcid": "0000-0003-1284-6911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/656c7e73de8c47eb917ef817a44f716e.json"}}, {"family": "Andersson", "given": "Kerstin", "initials": "K"}, {"family": "Andersson", "given": "Christer", "initials": "C"}, {"family": "J\u00e4rbur", "given": "Katarina", "initials": "K"}, {"family": "Pullerits", "given": "Rille", "initials": "R"}, {"family": "Idorn", "given": "Manja", "initials": "M"}, {"family": "Paludan", "given": "Soren R", "initials": "SR"}, {"family": "Eriksson", "given": "Kristina", "initials": "K"}, {"family": "Wenner\u00e5s", "given": "Christine", "initials": "C"}], "type": "journal article", "published": "2022-02-07", "journal": {"title": "Eur J Immunol", "issn": "1521-4141", "issn-l": null}, "abstract": "The patterns of humoral and cellular responses to SARS-CoV-2 were studied in Swedish primary health care workers (n = 156) for 6 months during the Covid-19 pandemic. Serum IgA and IgG to SARS-CoV-2, T cell proliferation and cytokine secretion, demographic and clinical data, PCR-verified infection, and self-reported symptoms were monitored. The multivariate method OPLS-DA was used to identify immune response patterns coupled to protection from Covid-19. Contracting Covid-19 was associated with SARS-CoV-2-specific neutralizing serum IgG, T cell, interferon-\u03b3 and granzyme B responses to SARS-CoV-2, self-reported typical Covid-19 symptoms, male sex, higher BMI and hypertension. Not contracting Covid-19 was associated with female sex, IgA-dominated or no antibody responses to SARS-CoV-2, airborne allergy, and smoking. The IgG-responders had SARS-CoV-2-specific T cell responses including a cytotoxic CD4+ T cell population expressing CD25, CD38, CD69, CD194, CD279, CTLA-4 and granzyme B. IgA-responders with no IgG response to SARS-CoV-2 constituted 10% of the study population. The IgA responses were partially neutralizing and only seen in individuals who did not succumb to Covid-19. To conclude, serum IgG-dominated responses correlated with T cell responses to SARS-CoV-2 and PCR-confirmed Covid-19, whereas IgA-dominated responses correlated with not contracting the infection. This article is protected by copyright. All rights reserved.", "doi": "10.1002/eji.202149655", "pmid": "35128644", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-08T15:12:06.038Z", "modified": "2022-02-08T15:12:36.409Z"}, {"entity": "publication", "iuid": "76290bd128cb4379b2453a6888629443", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76290bd128cb4379b2453a6888629443.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76290bd128cb4379b2453a6888629443"}}, "title": "Status of Planned and Ongoing Paediatric Trials Investigating COVID-19 Vaccines: A Cross-Sectional Study of Paediatric Clinical Trials Planned in Agreed PIPs and/or Registered in Clinical Trial Databases.", "authors": [{"family": "Christiansen", "given": "Helle", "initials": "H", "orcid": "0000-0003-4893-4622", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1e17e022f4d40a9bc2e3f04e1fb1115.json"}}, {"family": "Thirstrup", "given": "Steffen", "initials": "S"}, {"family": "Hallgreen", "given": "Christine Erikstrup", "initials": "CE"}], "type": "journal article", "published": "2022-02-07", "journal": {"title": "Ther Innov Regul Sci", "issn": "2168-4804", "issn-l": null}, "abstract": "The immune system matures throughout childhood; therefore, evidence about the safety and efficacy of vaccines for the prevention of COVID-19 in the paediatric population is important. Efficacy and safety have not been established for COVID-19 vaccines in a large part of the paediatric population at the time of the initial approval for use in adults. This study aims to provide an overview of planned and ongoing paediatric clinical trials investigating the safety and/or efficacy of COVID-19.\n\nWe identified all paediatric clinical trials investigating the safety and/or efficacy of COVID-19 vaccines in clinicaltrials.gov and clinicaltrialregister.eu, as well as all clinical trials planned in agreed PIPs (Paediatric Investigational Plans) as of 11 June 2021. Information about the study design, the paediatric age groups that they included, and the primary and secondary safety and efficacy outcomes were collected, together with expected timelines for the studies.\n\n21 clinical trials were identified through the clinical trial registries and 19 clinical trials were specified in 6 agreed PIPs, 5 of these trials were also in the trial registers. All PIPs stipulated development of the COVID-19 vaccines for the full paediatric population, with a deferral. The earliest expected completion date of a PIPs is March 2024. The majority (14/21) of registered trials are randomised double-blinded studies. All investigated safety, 20 have a surrogate efficacy outcome (immunogenicity), of these 7 also measure clinical efficacy (COVID-19 infections). 18 studies were initiated, of these, all but one is still ongoing and one in adolescents has been finalised.\n\nEven though several trials have been planned in agreed PIPs, the registered paediatric clinical trials identified are most often not part of a PIP.", "doi": "10.1007/s43441-021-00356-y", "pmid": "35129826", "labels": {"Category: Health": null, "Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s43441-021-00356-y"}], "notes": [], "created": "2022-02-08T15:11:35.057Z", "modified": "2022-02-08T15:11:35.125Z"}, {"entity": "publication", "iuid": "54881f5454a14988b68f80c0062998ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54881f5454a14988b68f80c0062998ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54881f5454a14988b68f80c0062998ff"}}, "title": "Corrigendum to \"Presymptomatic viral shedding and infective ability of SARS-CoV-2; a case report\" <[Heliyon Volume 7, Issue 2, February 2021, Article e06328]>.", "authors": [{"family": "Nissen", "given": "Karolina", "initials": "K"}, {"family": "Hagbom", "given": "Marie", "initials": "M"}, {"family": "Krambrich", "given": "Janina", "initials": "J"}, {"family": "Akaberi", "given": "Dario", "initials": "D"}, {"family": "Sharma", "given": "Sumit", "initials": "S"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Svensson", "given": "Lennart", "initials": "L"}, {"family": "Bondeson", "given": "K\u00e5re", "initials": "K"}, {"family": "Salaneck", "given": "Erik", "initials": "E"}], "type": "published erratum", "published": "2022-02-05", "journal": {"title": "Heliyon", "issn": "2405-8440", "pages": "e08906", "issn-l": null}, "abstract": "[This corrects the article DOI: 10.1016/j.heliyon.2021.e06328.].", "doi": "10.1016/j.heliyon.2022.e08906", "pmid": "35155841", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(22)00194-3"}, {"db": "pmc", "key": "PMC8816836"}], "notes": [], "created": "2022-02-17T06:12:14.171Z", "modified": "2022-02-17T06:12:14.177Z"}, {"entity": "publication", "iuid": "40c1407d4e1d4e958520c51db97cdfc0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/40c1407d4e1d4e958520c51db97cdfc0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/40c1407d4e1d4e958520c51db97cdfc0"}}, "title": "Anti-SARS-CoV-2 Action of 5\u03b1-Reductase Inhibitors May be Mediated by Dehydroepiandrosterone.", "authors": [{"family": "Papadopoulos", "given": "Konstantinos I", "initials": "KI", "orcid": "0000-0003-0041-7853", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/57c63fdf7036465686e79794a5107544.json"}}, {"family": "Papadopoulou", "given": "Alexandra", "initials": "A", "orcid": "0000-0002-7488-8271", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9000ff7673bc4d35bde729ce8829ab5d.json"}}, {"family": "Sutheesophon", "given": "Warachaya", "initials": "W", "orcid": "0000-0002-1823-3852", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fab7d634e454e24989da629eafe21dc.json"}}, {"family": "Aw", "given": "Tar-Choon", "initials": "TC", "orcid": "0000-0002-7814-8836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f95d6a8535d41fbb7b5cf40fb091205.json"}}], "type": "letter", "published": "2022-02-04", "journal": {"title": "J Urol", "issn": "1527-3792", "pages": "101097JU0000000000002469", "issn-l": null}, "abstract": null, "doi": "10.1097/JU.0000000000002469", "pmid": "35119308", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2022-02-06T16:45:38.320Z", "modified": "2022-02-08T15:18:26.096Z"}, {"entity": "publication", "iuid": "18b782025bf84c03a2034b37e4eb7d15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18b782025bf84c03a2034b37e4eb7d15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18b782025bf84c03a2034b37e4eb7d15"}}, "title": "RT-PCR cycle threshold value in combination with visual scoring of chest computed tomography at hospital admission predicts outcome in COVID-19.", "authors": [{"family": "Ingberg", "given": "Edvin", "initials": "E"}, {"family": "Ahlstrand", "given": "Erik", "initials": "E"}, {"family": "Cajander", "given": "Per", "initials": "P"}, {"family": "L\u00f6f", "given": "Erika", "initials": "E"}, {"family": "Sundqvist", "given": "Martin", "initials": "M"}, {"family": "Wegener", "given": "Matthias", "initials": "M"}, {"family": "Lid\u00e9n", "given": "Mats", "initials": "M", "orcid": "0000-0002-1346-1450", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2a16a7027194ab9a32ab284641491a4.json"}}, {"family": "Cajander", "given": "Sara", "initials": "S"}], "type": "journal article", "published": "2022-02-03", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "pages": "1-10", "issn-l": "2374-4235"}, "abstract": "COVID-19 has a most variable prognosis. Several risk factors for an unfavourable outcome have been identified including extensive lung involvement on chest CT and high viral load estimated by RT-PCR cycle threshold (Ct) values. We investigated Ct value for outcome prediction, relation between Ct value and extent of lung involvement on chest CT and the combination of Ct value and chest CT lung involvement to predict outcome in COVID-19.\n\nPopulation-based retrospective study on all patients (n = 286) hospitalised for COVID-19 in \u00d6rebro Region, Sweden, between 1 March and 31 August 2020. Nasopharyngeal samples and chest CT at hospital admission were evaluated in relation to outcome of COVID-19.\n\nBoth Ct value and chest CT lung involvement were independently associated with risk for ICU admission or death. Lung involvement was superior as a single parameter, but addition of Ct value increased the prediction performance. Ct value was especially useful to identify patients with high risk for severe disease despite limited lung involvement.\n\nThe addition of RT-PCR Ct value to the assessment of lung involvement on chest CT adds valuable prognostic information in COVID-19. We believe that this information can be used to support clinical decision-making when managing COVID-19 patients.", "doi": "10.1080/23744235.2022.2035428", "pmid": "35114897", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-06T16:47:42.595Z", "modified": "2022-02-06T16:47:42.658Z"}, {"entity": "publication", "iuid": "29ba0134e3e54eb69d2f4b296a8d79b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/29ba0134e3e54eb69d2f4b296a8d79b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/29ba0134e3e54eb69d2f4b296a8d79b3"}}, "title": "ESCMID guidelines on testing for SARS-CoV-2 in asymptomatic individuals to prevent transmission in the healthcare setting.", "authors": [{"family": "Carrara", "given": "Elena", "initials": "E"}, {"family": "Ong", "given": "David S Y", "initials": "DSY"}, {"family": "Hussein", "given": "Khetam", "initials": "K"}, {"family": "Keske", "given": "Siran", "initials": "S"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}, {"family": "Presterl", "given": "Elisabeth", "initials": "E"}, {"family": "Tsioutis", "given": "Constantinos", "initials": "C"}, {"family": "Tschudin-Sutter", "given": "Sarah", "initials": "S"}, {"family": "Tacconelli", "given": "Evelina", "initials": "E"}], "type": "journal article", "published": "2022-02-03", "journal": {"title": "Clin Microbiol Infect", "issn": "1469-0691", "issn-l": null}, "abstract": "This guideline addresses the indications for direct testing of SARS-CoV-2 in asymptomatic individuals in healthcare facilities with the aim to prevent SARS-CoV-2 transmissions in these settings. The benefit of testing asymptomatic individuals to create a safe environment for patients and healthcare workers must be weighed against potential unintended consequences including delaying necessary treatments due to false positive results and lower quality of care due to strict isolation measures.\n\nA total of 9 PICOs on the topic of testing asymptomatic individuals was selected by the panel members. Subsequently, a literature search for existing guidelines and systematic reviews was performed on Pubmed, Epistemonikos, and RecMap using relevant filters available in each database. Data about article/recommendation type, setting, target population, intervention, and quality of the evidence were extracted. Credibility of the systematic reviews were evaluated using the AMSTAR-tool, and level of agreement with available recommendation was evaluated with the AGREE II-score. Because the evidence available from systematic reviews was deemed insufficiently updated to formulate relevant recommendations, an additional search targeting relevant guidance documents from major public health institutions and original studies was performed. Provisional recommendations were discussed via web conferences until agreement was reached and final recommendations was formulated according to the GRADE approach. Questions addressed by the guideline and recommendations: Recommendations were formulated regarding systematic testing in asymptomatic individuals upon admission to a healthcare setting, during hospital stay, prior to elective procedures, and prior to scheduled non-surgical procedures. Moreover, recommendations regarding testing of asymptomatic visitors, personal caregivers and healthcare workers in healthcare facilities were presented. Also, recommendations were given on contact tracing in asymptomatic patients or healthcare workers, and the possibility of a negative screening test to shorten the quarantine period. Furthermore, if applicable, recommendations were specified to transmission rate and vaccination coverage.", "doi": "10.1016/j.cmi.2022.01.007", "pmid": "35124258", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(22)00030-1"}], "notes": [], "created": "2022-02-08T15:16:03.487Z", "modified": "2022-02-08T15:16:03.501Z"}, {"entity": "publication", "iuid": "4a81b2ae9bc84e28a41303f76a7ba873", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4a81b2ae9bc84e28a41303f76a7ba873.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4a81b2ae9bc84e28a41303f76a7ba873"}}, "title": "Clinical and histology features as predictor of severity of mucormycosis in post-COVID-19 patients: An experience from a rural tertiary setting in Central India.", "authors": [{"family": "Jain", "given": "Kavita", "initials": "K", "orcid": "0000-0002-2024-9861", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/765cbc86e8fc41b3818f457b82bcc442.json"}}, {"family": "Surana", "given": "Akshay", "initials": "A"}, {"family": "Choudhary", "given": "Tej Singh", "initials": "TS"}, {"family": "Vaidya", "given": "Sudhakar", "initials": "S"}, {"family": "Nandedkar", "given": "Shirish", "initials": "S"}, {"family": "Purohit", "given": "Manju", "initials": "M", "orcid": "0000-0001-5385-7305", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4b7ea75e9964d40b1d34c569f4197f1.json"}}], "type": "journal article", "published": "2022-02-03", "journal": {"title": "SAGE Open Med", "issn": "2050-3121", "volume": "10", "pages": "20503121221074785", "issn-l": null}, "abstract": "An upsurge in cases of rhinosinusitis with or without associated orbital and/or cerebral involvement by mucormycosis has been observed in post-COVID-19 patients. Our objective is to evaluate the clinical and histopathology features of these patients to determine the severity and develop a scoring on the extent on tissue invasion.\n\nWe prospectively enrolled and analyzed 95 post-COVID-19 patients who presented with the invasive mucormycosis of the head and neck region. Clinical and histology details were noted in predesigned forms. Various histology variables were graded from I to III to propose a scoring system for the severity of the disease.\n\nMucormycosis was common in males with a mean age of 46.8 \u00b1 11 years. Facial pain was the most common presenting complaint and 77% of the patients were diabetic. Most cases (n = 59) showed a moderate degree of neutrophilic infiltrate with \u2a7e50% tissue necrosis and angioinvasion in three or more vessels with a fungal load of 2+/3+. Histology severity grade III was observed in patients who died from cerebral mucormycosis (n = 3) and septicemia (n = 2) and in patients who had undergone orbital exenteration (n = 6).\n\nThe histopathology and severity score classification was directly correlated with the outcome of the patients. Further evaluation and a larger study will help to validate the proposed scoring for its clinical use in all forms and causes of mucormycosis.", "doi": "10.1177/20503121221074785", "pmid": "35140976", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1177_20503121221074785"}, {"db": "pmc", "key": "PMC8819781"}], "notes": [], "created": "2022-02-11T10:23:44.934Z", "modified": "2022-02-11T10:23:45.065Z"}, {"entity": "publication", "iuid": "30b1695564e547bc94c8255556c21995", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/30b1695564e547bc94c8255556c21995.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/30b1695564e547bc94c8255556c21995"}}, "title": "COVID-19 vaccination in the setting of mastocytosis - Pfizer-BioNTech mRNA vaccine is safe and well-tolerated.", "authors": [{"family": "Lazarinis", "given": "Nikolaos", "initials": "N"}, {"family": "Bossios", "given": "Apostolos", "initials": "A"}, {"family": "G\u00fclen", "given": "Theo", "initials": "T"}], "type": "journal article", "published": "2022-02-02", "journal": {"title": "J Allergy Clin Immunol Pract", "issn": "2213-2201", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jaip.2022.01.037", "pmid": "35123098", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2213-2198(22)00117-9"}, {"db": "pmc", "key": "PMC8810433"}], "notes": [], "created": "2022-02-06T16:44:49.496Z", "modified": "2022-02-08T15:17:54.397Z"}, {"entity": "publication", "iuid": "f7f150de5b4244bc8f2c07f33b2b57ab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7f150de5b4244bc8f2c07f33b2b57ab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7f150de5b4244bc8f2c07f33b2b57ab"}}, "title": "Analytical observational study evaluating global pandemic preparedness and the effectiveness of early COVID-19 responses in Ethiopia, Nigeria, Singapore, South Korea, Sweden, Taiwan, UK and USA.", "authors": [{"family": "Nikolaeva", "given": "Alexandra", "initials": "A", "orcid": "0000-0001-9876-8250", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72b6128366414c6abb9a9a53c6fe605b.json"}}, {"family": "Versnel", "given": "Jenny", "initials": "J"}], "type": "journal article", "published": "2022-02-02", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "2", "pages": "e053374", "issn-l": "2044-6055"}, "abstract": "An analysis of early country-specific COVID-19 strategies and the impact of policies, healthcare resources and cultural influences on their effectiveness.\n\nAnalytical observational study.\n\nUSA, UK, Sweden, South Korea, Singapore, Taiwan, Ethiopia and Nigeria.\n\nOxCGRT indices were used to quantify variations in governments' responses, and effectiveness was measured by the number of deaths as a proportion of the population. Hofstede's cultural dimensions, and the availability of healthcare resources, were analysed for their potential impact on effectiveness.\n\nEffective strategies reflect factors such as speed of governmental intervention, cultural norms, population demographics and available resources. While biases, confounders and lack of data at the beginning of the pandemic make inferences challenging, publicly available data suggest that South Korea, Singapore and Taiwan were most successful through rapid identification and isolation of cases, and effective contact tracing systems.\n\nThe rapid spread of the highly transmissible SARS-CoV-2 virus took many countries by surprise and the delayed global response contributed to the severity of the COVID-19 pandemic. The speed at which strategies were implemented is highly correlated to the number of deaths. Factors such as cultural norms and healthcare resources impact effectiveness significantly, implying that implementation of a global 'one size fits all' approach is challenging. Global preparedness should focus on effective surveillance and preparedness strategies to enable timely identification and containment of future threats.", "doi": "10.1136/bmjopen-2021-053374", "pmid": "35110318", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-053374"}, {"db": "pmc", "key": "PMC8811275"}], "notes": [], "created": "2022-02-06T16:49:10.101Z", "modified": "2022-02-06T16:49:10.157Z"}, {"entity": "publication", "iuid": "1e0441ac55c94d91855aaf702ae739a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1e0441ac55c94d91855aaf702ae739a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1e0441ac55c94d91855aaf702ae739a1"}}, "title": "Allergies and COVID-19 vaccines: An ENDA/EAACI Position paper.", "authors": [{"family": "Barbaud", "given": "Annick", "initials": "A"}, {"family": "Garvey", "given": "Lene Heise", "initials": "LH", "orcid": "0000-0002-7777-4501", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77c921b2de6f4d9ea19c1cfea043c502.json"}}, {"family": "Arcolaci", "given": "Alessandra", "initials": "A"}, {"family": "Brockow", "given": "Knut", "initials": "K", "orcid": "0000-0002-2775-3681", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91fc8e9e37ab420fbf2a18c3eb063b71.json"}}, {"family": "Mori", "given": "Francesca", "initials": "F"}, {"family": "Mayorga", "given": "Cristobalina", "initials": "C"}, {"family": "Bonadonna", "given": "Patrizia", "initials": "P", "orcid": "0000-0002-5703-5314", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/220301cdd99d401095b70eadd8cb4b30.json"}}, {"family": "Atanaskovic-Markovic", "given": "Marina", "initials": "M", "orcid": "0000-0003-1354-6072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83efadf622ac4e8f975a4f7edddcda71.json"}}, {"family": "Moral", "given": "Luis", "initials": "L", "orcid": "0000-0002-7066-6073", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e60105059bd74801b78fba9826622c0c.json"}}, {"family": "Zanoni", "given": "Giovanna", "initials": "G"}, {"family": "Pagani", "given": "Mauro", "initials": "M", "orcid": "0000-0002-0591-5416", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c1524ff0274c68a642c8a82c5a63fb.json"}}, {"family": "Soria", "given": "Ang\u00e8le", "initials": "A", "orcid": "0000-0002-8726-6658", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/38633c9e786c45118b3192482cee8436.json"}}, {"family": "Jo\u0161t", "given": "Maja", "initials": "M"}, {"family": "Caubet", "given": "Jean-Christoph", "initials": "JC", "orcid": "0000-0001-5006-5724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8db20fc3c6842688b8f3be3f8742ef6.json"}}, {"family": "Abreu", "given": "Carmo", "initials": "C"}, {"family": "Al-Ahmad", "given": "Mona", "initials": "M"}, {"family": "Alvarez-Perea", "given": "Alberto", "initials": "A", "orcid": "0000-0001-7417-7309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e765e633592843ac887bbf59b533a8be.json"}}, {"family": "Bavbek", "given": "Sevim", "initials": "S", "orcid": "0000-0002-7884-0830", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd4648dd8218433d9891c4a100cd6495.json"}}, {"family": "Benedetta", "given": "Biagioni", "initials": "B"}, {"family": "Beatrice", "given": "Bilo M", "initials": "BM"}, {"family": "Blanca-L\u00f3pez", "given": "Natalia", "initials": "N", "orcid": "0000-0002-1492-9887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb6e84df33bc4b608b0a512b017d2a95.json"}}, {"family": "Bogas Herrera", "given": "G\u00e1dor", "initials": "G"}, {"family": "Buonomo", "given": "Alessandro", "initials": "A"}, {"family": "Calogiuri", "given": "Gianfranco", "initials": "G"}, {"family": "Carli", "given": "Giulia", "initials": "G", "orcid": "0000-0001-6400-9205", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1512d6895f1342d0aef6d2d669e5b638.json"}}, {"family": "Cernadas", "given": "Josefina", "initials": "J"}, {"family": "Cortellini", "given": "Gabriele", "initials": "G"}, {"family": "Celik", "given": "G\u00fclfem", "initials": "G", "orcid": "0000-0001-8654-513X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0bed9b33057341268ed0b5f0c00fc4db.json"}}, {"family": "Demir", "given": "Semra", "initials": "S"}, {"family": "Do\u00f1a", "given": "Inmaculada", "initials": "I", "orcid": "0000-0002-5309-4878", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32509c221e7e473faf9d8170af50cd19.json"}}, {"family": "Dursun Adile", "given": "Berna", "initials": "B"}, {"family": "Eberlein", "given": "Bernadette", "initials": "B", "orcid": "0000-0003-4509-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c7c092fc4c042f19a95fb904663bb7e.json"}}, {"family": "Emilia", "given": "Faria", "initials": "F"}, {"family": "Bryan", "given": "Fernandes", "initials": "F"}, {"family": "Garcez", "given": "Tomaz", "initials": "T"}, {"family": "Garcia-Nunez", "given": "Ignacio", "initials": "I"}, {"family": "Gawlik", "given": "Radoslaw", "initials": "R"}, {"family": "Gelincik", "given": "Asli", "initials": "A", "orcid": "0000-0002-3524-9952", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/266358f8a2974b5aa5fe91c75dcb9fcf.json"}}, {"family": "Gomes", "given": "Eva", "initials": "E"}, {"family": "Gooi", "given": "Jimmy Hc", "initials": "JH"}, {"family": "Grosber", "given": "Martine", "initials": "M"}, {"family": "G\u00fclen", "given": "Theo", "initials": "T"}, {"family": "Hacard", "given": "Florence", "initials": "F"}, {"family": "Cyrille", "given": "Hoarau", "initials": "H"}, {"family": "Janson", "given": "Christer", "initials": "C"}, {"family": "Johnston", "given": "Sebastian L", "initials": "SL"}, {"family": "Joerg", "given": "Lukas", "initials": "L", "orcid": "0000-0003-1512-4279", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e3fbf9104f74debab2cf215b242ad9a.json"}}, {"family": "Kepil \u00d6zdemir", "given": "Se\u00e7il", "initials": "S", "orcid": "0000-0003-2688-9867", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92809dfd8abd4491a916e5eb028c0c63.json"}}, {"family": "Klimek", "given": "Ludger", "initials": "L", "orcid": "0000-0002-2455-0192", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/faa1bbfb4833469db8c698a323958747.json"}}, {"family": "Ko\u0161nik", "given": "Mitja", "initials": "M", "orcid": "0000-0002-4701-7374", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27bf299d920c43559b858bdf014078be.json"}}, {"family": "Kowalski", "given": "Marek L", "initials": "ML"}, {"family": "Kuyucu", "given": "Semanur", "initials": "S"}, {"family": "Kvedariene", "given": "Violeta", "initials": "V"}, {"family": "Julio Laguna", "given": "Jose", "initials": "J"}, {"family": "Carla", "given": "Lombardo", "initials": "L"}, {"family": "Marinho", "given": "Susana", "initials": "S"}, {"family": "Merk", "given": "Hans", "initials": "H"}, {"family": "Meucci", "given": "Elisa", "initials": "E"}, {"family": "Morisset", "given": "Martine", "initials": "M", "orcid": "0000-0002-4028-703X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20f59dfbd72747db87c4a767899e6f82.json"}}, {"family": "Munoz-Cano", "given": "Rosa", "initials": "R", "orcid": "0000-0001-8566-8285", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4775ffb585f64514b502f7340b5d097e.json"}}, {"family": "Murzilli", "given": "Francesco", "initials": "F"}, {"family": "Nakonechna", "given": "Alla", "initials": "A"}, {"family": "Popescu", "given": "Florin-Dan", "initials": "FD"}, {"family": "Porebski", "given": "Grzegorz", "initials": "G", "orcid": "0000-0002-6146-0188", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d1ad79789ab45a5a022e7921f2655cd.json"}}, {"family": "Radice", "given": "Anna", "initials": "A"}, {"family": "Regateiro", "given": "Frederico S", "initials": "FS"}, {"family": "R\u00f6ckmann", "given": "Heike", "initials": "H"}, {"family": "Romano", "given": "Antonino", "initials": "A"}, {"family": "Sargur", "given": "Ravishankar", "initials": "R", "orcid": "0000-0002-8535-630X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b4169bbedcf4f6785f2077772d123ce.json"}}, {"family": "Sastre", "given": "Joaquin", "initials": "J"}, {"family": "Kathrin", "given": "Scherer Hofmeier", "initials": "SH"}, {"family": "Lenka", "given": "Sedl\u00e1\u010dkov\u00e1", "initials": "S"}, {"family": "Marta", "given": "Sobotkova", "initials": "S", "orcid": "0000-0003-3864-8008", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ca2adee8d1f4c94a69666cff8c20729.json"}}, {"family": "Ingrid", "given": "Terreehorst", "initials": "T"}, {"family": "Treudler", "given": "Regina", "initials": "R"}, {"family": "Walusiak-Skorupa", "given": "Jolanta", "initials": "J"}, {"family": "Wedi", "given": "Bettina", "initials": "B", "orcid": "0000-0002-9868-6308", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9715672937a4be5aad8eced12db8722.json"}}, {"family": "W\u00f6hrl", "given": "Stefan", "initials": "S", "orcid": "0000-0002-6324-0007", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89ec6d306f3f4fd98d35536a513277b8.json"}}, {"family": "Zidarn", "given": "Mihael", "initials": "M"}, {"family": "Zuberbier", "given": "Torsten", "initials": "T", "orcid": "0000-0002-1466-8875", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7dc091f64a240fd8fb6443292b812c6.json"}}, {"family": "Agache", "given": "Ioana", "initials": "I", "orcid": "0000-0001-7994-364X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25d9598f74414a38a868c2bcf545e94d.json"}}, {"family": "Torres", "given": "Maria J", "initials": "MJ", "orcid": "0000-0001-5228-471X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6558e75ee5494904a135d8cfe05c1927.json"}}], "type": "journal article", "published": "2022-02-02", "journal": {"title": "Allergy", "issn": "1398-9995", "issn-l": "0105-4538"}, "abstract": "Anaphylaxis, which is rare, has been reported after COVID 19 vaccination, but its management is not standardized.\n\nMembers of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interested in drug allergy participated in an online questionnaire on pre-vaccination screening and management of allergic reactions to COVID-19 vaccines, and literature was analysed.\n\nNo death due to anaphylaxis to COVID-19 vaccines has been confirmed in scientific literature. Potential allergens, polyethylene glycol (PEG), polysorbate and tromethamine, are excipients. The authors propose allergy evaluation of persons with the following histories: 1-anaphylaxis to injectable drug or vaccine containing PEG or derivatives; 2- anaphylaxis to oral/topical PEG containing products; 3-recurrent anaphylaxis of unknown cause; 4-suspected or confirmed allergy to any mRNA vaccine, 5-confirmed allergy to PEG or derivatives. We recommend a prick-to-prick skin test with the left over solution in the suspected vaccine vial to avoid waste. Prick test panel should include PEG 4000 or 3500, PEG 2000 and polysorbate 80. The value of in vitro test is arguable.\n\nThese recommendations, will lead to a better knowledge of the management and mechanisms involved in anaphylaxis to COVID-19 vaccines and enable more people with history of allergy to be vaccinated.", "doi": "10.1111/all.15241", "pmid": "35112371", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-06T16:47:24.640Z", "modified": "2022-02-06T16:47:25.500Z"}, {"entity": "publication", "iuid": "43321e1f33754836912d2d42cb4e6111", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/43321e1f33754836912d2d42cb4e6111.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/43321e1f33754836912d2d42cb4e6111"}}, "title": "Self-reported COVID-19 vaccine hesitancy and uptake among participants from different racial and ethnic groups in the United States and United Kingdom.", "authors": [{"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Merino", "given": "Jordi", "initials": "J", "orcid": "0000-0001-8312-1438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12ab049914a542b39affcfb4196861d2.json"}}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Lo", "given": "Chun-Han", "initials": "CH", "orcid": "0000-0001-8202-4513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a0d9111318f4084b64f47b5b56c8c85.json"}}, {"family": "Kwon", "given": "Sohee", "initials": "S", "orcid": "0000-0002-4201-9522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/850aeda246cd44e88071b97d54b358b5.json"}}, {"family": "Wang", "given": "Kai", "initials": "K"}, {"family": "Graham", "given": "Mark S", "initials": "MS"}, {"family": "Polidori", "given": "Lorenzo", "initials": "L"}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874802ae65824a90ba50eabdeabb8356.json"}}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Anyane-Yeboa", "given": "Adjoa", "initials": "A"}, {"family": "Astley", "given": "Christina M", "initials": "CM", "orcid": "0000-0002-5063-8470", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98ce30ec7a7d45389d75aba2defce392.json"}}, {"family": "Warner", "given": "Erica T", "initials": "ET"}, {"family": "Hu", "given": "Christina Y", "initials": "CY"}, {"family": "Selvachandran", "given": "Somesh", "initials": "S"}, {"family": "Davies", "given": "Richard", "initials": "R", "orcid": "0000-0003-2050-3994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b82cc92615f462d9af0153a6fb94fde.json"}}, {"family": "Nash", "given": "Denis", "initials": "D"}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74cf1f7094744ee289fa5df041e7cb5b.json"}}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-7284-6767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeefbf47fd384d5390109fe1a903bd18.json"}}, {"family": "COPE Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2022-02-01", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "636", "issn-l": "2041-1723"}, "abstract": "Worldwide, racial and ethnic minorities have been disproportionately impacted by COVID-19 with increased risk of infection, its related complications, and death. In the initial phase of population-based vaccination in the United States (U.S.) and United Kingdom (U.K.), vaccine hesitancy may result in differences in uptake. We performed a cohort study among U.S. and U.K. participants who volunteered to take part in the smartphone-based COVID Symptom Study (March 2020-February 2021) and used logistic regression to estimate odds ratios of vaccine hesitancy and uptake. In the U.S. (n = 87,388), compared to white participants, vaccine hesitancy was greater for Black and Hispanic participants and those reporting more than one or other race. In the U.K. (n = 1,254,294), racial and ethnic minority participants showed similar levels of vaccine hesitancy to the U.S. However, associations between participant race and ethnicity and levels of vaccine uptake were observed to be different in the U.S. and the U.K. studies. Among U.S. participants, vaccine uptake was significantly lower among Black participants, which persisted among participants that self-reported being vaccine-willing. In contrast, statistically significant racial and ethnic disparities in vaccine uptake were not observed in the U.K sample. In this study of self-reported vaccine hesitancy and uptake, lower levels of vaccine uptake in Black participants in the U.S. during the initial vaccine rollout may be attributable to both hesitancy and disparities in access.", "doi": "10.1038/s41467-022-28200-3", "pmid": "35105869", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-022-28200-3"}], "notes": [], "created": "2022-02-06T16:51:03.679Z", "modified": "2022-02-06T16:51:03.864Z"}, {"entity": "publication", "iuid": "2f8eb9d568d649e398c46824757736cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2f8eb9d568d649e398c46824757736cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2f8eb9d568d649e398c46824757736cc"}}, "title": "Conditionality of COVID-19 vaccine acceptance in European countries.", "authors": [{"family": "Heyerdahl", "given": "Leonardo W", "initials": "LW"}, {"family": "Vray", "given": "Muriel", "initials": "M"}, {"family": "Lana", "given": "Benedetta", "initials": "B"}, {"family": "Tvardik", "given": "Nastassia", "initials": "N"}, {"family": "Gobat", "given": "Nina", "initials": "N"}, {"family": "Wanat", "given": "Marta", "initials": "M"}, {"family": "Tonkin-Crine", "given": "Sarah", "initials": "S"}, {"family": "Anthierens", "given": "Sibyl", "initials": "S"}, {"family": "Goossens", "given": "Herman", "initials": "H"}, {"family": "Giles-Vernick", "given": "Tamara", "initials": "T"}], "type": "journal article", "published": "2022-02-01", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null}, "abstract": "The COVID-19 vaccine rollout has offered a powerful preventive measure to help control SARS-CoV-2 transmission. Nevertheless, long-standing public hesitation around vaccines heightened concerns that vaccine coverage would not achieve desired public health impacts, particularly in light of more contagious variants. This cross-sectional survey was conducted online just before the European vaccine rollout in December 2020 among 7000 respondents (aged 18-65) in Belgium, France, Germany, Italy, Spain, Sweden, and Ukraine. The survey included open text boxes for fuller explanation of responses. Overall, 56.9% of respondents would accept a COVID-19 vaccine, 19.0% would not, and 24.1% did not know or preferred not to say. By country, between 44% (France) and 66% (Italy) of respondents would accept a COVID-19 vaccine. Respondents expressed conditionality in open responses, voicing concerns about vaccine safety and mistrust of authorities. We highlight lessons learned about the dynamism of vaccine conditionality and persistence of safety concerns.", "doi": "10.1016/j.vaccine.2022.01.054", "pmid": "35125225", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(22)00099-8"}], "notes": [], "created": "2022-02-08T15:15:41.099Z", "modified": "2022-02-08T15:15:41.113Z"}, {"entity": "publication", "iuid": "d4948847193e46a89360c70bc03170dc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4948847193e46a89360c70bc03170dc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4948847193e46a89360c70bc03170dc"}}, "title": "Variations in the financial impact of the COVID-19 pandemic across 5 continents: A cross-sectional, individual level analysis.", "authors": [{"family": "Khetan", "given": "Aditya K", "initials": "AK"}, {"family": "Yusuf", "given": "Salim", "initials": "S"}, {"family": "Lopez-Jaramillo", "given": "Patricio", "initials": "P"}, {"family": "Szuba", "given": "Andrzej", "initials": "A"}, {"family": "Orlandini", "given": "Andres", "initials": "A"}, {"family": "Mat-Nasir", "given": "Nafiza", "initials": "N"}, {"family": "Oguz", "given": "Aytekin", "initials": "A"}, {"family": "Gupta", "given": "Rajeev", "initials": "R"}, {"family": "Avezum", "given": "\u00c1lvaro", "initials": "\u00c1"}, {"family": "Rosnah", "given": "Ismail", "initials": "I"}, {"family": "Poirier", "given": "Paul", "initials": "P"}, {"family": "Teo", "given": "Koon K", "initials": "KK"}, {"family": "Wielgosz", "given": "Andreas", "initials": "A"}, {"family": "Lear", "given": "Scott A", "initials": "SA"}, {"family": "Palileo-Villanueva", "given": "Lia M", "initials": "LM"}, {"family": "Ser\u00f3n", "given": "Pamela", "initials": "P"}, {"family": "Chifamba", "given": "Jephat", "initials": "J"}, {"family": "Rangarajan", "given": "Sumathy", "initials": "S"}, {"family": "Mushtaha", "given": "Maha", "initials": "M"}, {"family": "Mohan", "given": "Deepa", "initials": "D"}, {"family": "Yeates", "given": "Karen", "initials": "K"}, {"family": "McKee", "given": "Martin", "initials": "M"}, {"family": "Mony", "given": "Prem K", "initials": "PK"}, {"family": "Walli-Attaei", "given": "Marjan", "initials": "M"}, {"family": "Khansaheb", "given": "Hamda", "initials": "H"}, {"family": "Rosengren", "given": "Annika", "initials": "A"}, {"family": "Alhabib", "given": "Khalid F", "initials": "KF"}, {"family": "Kruger", "given": "Iolanth\u00e9 M", "initials": "IM"}, {"family": "Paucar", "given": "Mar\u00eda-Jos\u00e9", "initials": "MJ"}, {"family": "Mirrakhimov", "given": "Erkin", "initials": "E"}, {"family": "Assembekov", "given": "Batyrbek", "initials": "B"}, {"family": "Leong", "given": "Darryl P", "initials": "DP"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": "44", "pages": "101284", "issn-l": null}, "abstract": "COVID-19 has caused profound socio-economic changes worldwide. However, internationally comparative data regarding the financial impact on individuals is sparse. Therefore, we conducted a survey of the financial impact of the pandemic on individuals, using an international cohort that has been well-characterized prior to the pandemic.\n\nBetween August 2020 and September 2021, we surveyed 24,506 community-dwelling participants from the Prospective Urban-Rural Epidemiology (PURE) study across high (HIC), upper middle (UMIC)-and lower middle (LMIC)-income countries. We collected information regarding the impact of the pandemic on their self-reported personal finances and sources of income.\n\nOverall, 32.4% of participants had suffered an adverse financial impact, defined as job loss, inability to meet financial obligations or essential needs, or using savings to meet financial obligations. 8.4% of participants had lost a job (temporarily or permanently); 14.6% of participants were unable to meet financial obligations or essential needs at the time of the survey and 16.3% were using their savings to meet financial obligations. Participants with a post-secondary education were least likely to be adversely impacted (19.6%), compared with 33.4% of those with secondary education and 33.5% of those with pre-secondary education. Similarly, those in the highest wealth tertile were least likely to be financially impacted (26.7%), compared with 32.5% in the middle tertile and 30.4% in the bottom tertile participants. Compared with HICs, financial impact was greater in UMIC [odds ratio of 2.09 (1.88-2.33)] and greatest in LMIC [odds ratio of 16.88 (14.69-19.39)]. HIC participants with the lowest educational attainment suffered less financial impact (15.1% of participants affected) than those with the highest education in UMIC (22.0% of participants affected). Similarly, participants with the lowest education in UMIC experienced less financial impact (28.3%) than those with the highest education in LMIC (45.9%). A similar gradient was seen across country income categories when compared by pre-pandemic wealth status.\n\nThe financial impact of the pandemic differs more between HIC, UMIC, and LMIC than between socio-economic categories within a country income level. The most disadvantaged socio-economic subgroups in HIC had a lower financial impact from the pandemic than the most advantaged subgroup in UMIC, with a similar disparity seen between UMIC and LMIC. Continued high levels of infection will exacerbate financial inequity between countries and hinder progress towards the sustainable development goals, emphasising the importance of effective measures to control COVID-19 and, especially, ensuring high vaccine coverage in all countries.\n\nFunding for this study was provided by the Canadian Institutes of Health Research and the International Development Research Centre.", "doi": "10.1016/j.eclinm.2022.101284", "pmid": "35106472", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(22)00014-1"}, {"db": "pmc", "key": "PMC8794545"}], "notes": [], "created": "2022-02-06T16:50:23.395Z", "modified": "2022-02-06T16:50:23.408Z"}, {"entity": "publication", "iuid": "cd6a3a5d47334aa6a79c66e514409e4e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd6a3a5d47334aa6a79c66e514409e4e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd6a3a5d47334aa6a79c66e514409e4e"}}, "title": "The benefits, costs and feasibility of a low incidence COVID-19 strategy.", "authors": [{"family": "Czypionka", "given": "Thomas", "initials": "T"}, {"family": "Iftekhar", "given": "Emil N", "initials": "EN"}, {"family": "Prainsack", "given": "Barbara", "initials": "B"}, {"family": "Priesemann", "given": "Viola", "initials": "V"}, {"family": "Bauer", "given": "Simon", "initials": "S"}, {"family": "Calero Valdez", "given": "Andr\u00e9", "initials": "A"}, {"family": "Cuschieri", "given": "Sarah", "initials": "S"}, {"family": "Glaab", "given": "Enrico", "initials": "E"}, {"family": "Grill", "given": "Eva", "initials": "E"}, {"family": "Krutzinna", "given": "Jenny", "initials": "J"}, {"family": "Lionis", "given": "Christos", "initials": "C"}, {"family": "Machado", "given": "Helena", "initials": "H"}, {"family": "Martins", "given": "Carlos", "initials": "C"}, {"family": "Pavlakis", "given": "George N", "initials": "GN"}, {"family": "Perc", "given": "Matja\u017e", "initials": "M"}, {"family": "Petelos", "given": "Elena", "initials": "E"}, {"family": "Pickersgill", "given": "Martyn", "initials": "M"}, {"family": "Skupin", "given": "Alexander", "initials": "A"}, {"family": "Schernhammer", "given": "Eva", "initials": "E"}, {"family": "Szczurek", "given": "Ewa", "initials": "E"}, {"family": "Tsiodras", "given": "Sotirios", "initials": "S"}, {"family": "Willeit", "given": "Peter", "initials": "P"}, {"family": "Wilmes", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "13", "pages": "100294", "issn-l": null}, "abstract": "In the summer of 2021, European governments removed most NPIs after experiencing prolonged second and third waves of the COVID-19 pandemic. Most countries failed to achieve immunization rates high enough to avoid resurgence of the virus. Public health strategies for autumn and winter 2021 have ranged from countries aiming at low incidence by re-introducing NPIs to accepting high incidence levels. However, such high incidence strategies almost certainly lead to the very consequences that they seek to avoid: restrictions that harm people and economies. At high incidence, the important pandemic containment measure 'test-trace-isolate-support' becomes inefficient. At that point, the spread of SARS-CoV-2 and its numerous harmful consequences can likely only be controlled through restrictions. We argue that all European countries need to pursue a low incidence strategy in a coordinated manner. Such an endeavour can only be successful if it is built on open communication and trust.", "doi": "10.1016/j.lanepe.2021.100294", "pmid": "35005678", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00280-5"}, {"db": "pmc", "key": "PMC8720492"}], "notes": [], "created": "2022-01-13T21:09:51.362Z", "modified": "2022-01-13T21:09:51.378Z"}, {"entity": "publication", "iuid": "a36849b91d9f402f973b726bd0da8b38", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a36849b91d9f402f973b726bd0da8b38.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a36849b91d9f402f973b726bd0da8b38"}}, "title": "Risk of infection, hospitalisation, and death up to 9 months after a second dose of COVID-19 vaccine: a retrospective, total population cohort study in Sweden", "authors": [{"family": "Nordstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Ballin", "given": "Marcel", "initials": "M"}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal-article", "published": "2022-02-00", "journal": {"title": "Lancet", "issn": "0140-6736", "issn-l": null}, "abstract": null, "doi": "10.1016/s0140-6736(22)00089-7", "pmid": null, "labels": {"Category: Health": null, "Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-08T15:10:34.563Z", "modified": "2022-02-08T15:10:34.575Z"}, {"entity": "publication", "iuid": "0de9bcdefa794cf0a6b6b4c519a9c53e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0de9bcdefa794cf0a6b6b4c519a9c53e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0de9bcdefa794cf0a6b6b4c519a9c53e"}}, "title": "Quality of facility-based maternal and newborn care around the time of childbirth during the COVID-19 pandemic: online survey investigating maternal perspectives in 12 countries of the WHO European Region.", "authors": [{"family": "Lazzerini", "given": "Marzia", "initials": "M"}, {"family": "Covi", "given": "Benedetta", "initials": "B"}, {"family": "Mariani", "given": "Ilaria", "initials": "I"}, {"family": "Drglin", "given": "Zalka", "initials": "Z"}, {"family": "Arendt", "given": "Maryse", "initials": "M"}, {"family": "Nedberg", "given": "Ingvild Hersoug", "initials": "IH"}, {"family": "Elden", "given": "Helen", "initials": "H"}, {"family": "Costa", "given": "Raquel", "initials": "R"}, {"family": "Drandi\u0107", "given": "Daniela", "initials": "D"}, {"family": "Radeti\u0107", "given": "Jelena", "initials": "J"}, {"family": "Otelea", "given": "Marina Ruxandra", "initials": "MR"}, {"family": "Miani", "given": "C\u00e9line", "initials": "C"}, {"family": "Brigidi", "given": "Serena", "initials": "S"}, {"family": "Roz\u00e9e", "given": "Virginie", "initials": "V"}, {"family": "Ponikvar", "given": "Barbara Mihevc", "initials": "BM"}, {"family": "Tasch", "given": "Barbara", "initials": "B"}, {"family": "Kongslien", "given": "Sigrun", "initials": "S"}, {"family": "Linden", "given": "Karolina", "initials": "K"}, {"family": "Barata", "given": "Catarina", "initials": "C"}, {"family": "Kurbanovi\u0107", "given": "Magdalena", "initials": "M"}, {"family": "Ru\u017ei\u010di\u0107", "given": "Jovana", "initials": "J"}, {"family": "Batram-Zantvoort", "given": "Stephanie", "initials": "S"}, {"family": "Casta\u00f1eda", "given": "Lara Mart\u00edn", "initials": "LM"}, {"family": "Rochebrochard", "given": "Elise de La", "initials": "E"}, {"family": "Bohinec", "given": "Anja", "initials": "A"}, {"family": "Vik", "given": "Eline Skirnisdottir", "initials": "ES"}, {"family": "Zaigham", "given": "Mehreen", "initials": "M"}, {"family": "Santos", "given": "Teresa", "initials": "T"}, {"family": "Wandschneider", "given": "Lisa", "initials": "L"}, {"family": "Viver", "given": "Ana Canales", "initials": "AC"}, {"family": "\u0106erimagi\u0107", "given": "Amira", "initials": "A"}, {"family": "Sacks", "given": "Emma", "initials": "E"}, {"family": "Valente", "given": "Emanuelle Pessa", "initials": "EP"}, {"family": "IMAgiNE EURO study group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "13", "pages": "100268", "issn-l": null}, "abstract": "Multi-country studies assessing the quality of maternal and newborn care (QMNC) during the COVID-19 pandemic, as defined by WHO Standards, are lacking.\n\nWomen who gave birth in 12 countries of the WHO European Region from March 1, 2020 - March 15, 2021 answered an online questionnaire, including 40 WHO Standard-based Quality Measures.\n\n21,027 mothers were included in the analysis. Among those who experienced labour (N=18,063), 41\u00b78% (26\u00b71%- 63\u00b75%) experienced difficulties in accessing antenatal care, 62% (12\u00b76%-99\u00b70%) were not allowed a companion of choice, 31\u00b71% (16\u00b75%-56\u00b79%) received inadequate breastfeeding support, 34\u00b74% (5\u00b72%-64\u00b78%) reported that health workers were not always using protective personal equipment, and 31\u00b78% (17\u00b78%-53\u00b71%) rated the health workers' number as \"insufficient\". Episiotomy was performed in 20\u00b71% (6\u00b71%-66\u00b70%) of spontaneous vaginal births and fundal pressure applied in 41\u00b72% (11\u00b75% -100%) of instrumental vaginal births. In addition, 23\u00b79% women felt they were not treated with dignity (12\u00b78%-59\u00b78%), 12\u00b75% (7\u00b70%-23\u00b74%) suffered abuse, and 2\u00b74% (0\u00b71%-26\u00b72%) made informal payments. Most findings were significantly worse among women with prelabour caesarean birth (N=2,964). Multivariate analyses confirmed significant differences among countries, with Croatia, Romania, Serbia showing significant lower QMNC Indexes and Luxemburg showing a significantly higher QMNC Index than the total sample. Younger women and those with operative births also reported significantly lower QMNC Indexes.\n\nMothers reports revealed large inequities in QMNC across countries of the WHO European Region. Quality improvement initiatives to reduce these inequities and promote evidence-based, patient-centred respectful care for all mothers and newborns during the COVID-19 pandemic and beyond are urgently needed.\n\nThe study was financially supported by the Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy.\n\nClinicalTrials.gov Identifier: NCT04847336.", "doi": "10.1016/j.lanepe.2021.100268", "pmid": "34977838", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00254-4"}, {"db": "pmc", "key": "PMC8703114"}, {"db": "ClinicalTrials.gov", "key": "NCT04847336"}], "notes": [], "created": "2022-01-04T14:44:07.308Z", "modified": "2022-01-04T14:44:07.321Z"}, {"entity": "publication", "iuid": "c5f19e306adb4417b8cf7ec7c7f08643", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5f19e306adb4417b8cf7ec7c7f08643.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5f19e306adb4417b8cf7ec7c7f08643"}}, "title": "Mortality in hospitalized COVID-19 patients was associated with the COVID-19 admission rate during the first year of the pandemic in Sweden.", "authors": [{"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Wahlstr\u00f6m", "given": "Erik", "initials": "E"}, {"family": "Walther", "given": "Sten", "initials": "S"}, {"family": "Bennet-Bark", "given": "Anna M", "initials": "AM"}, {"family": "Heurgren", "given": "Mona", "initials": "M"}, {"family": "Lind\u00e9n", "given": "Thomas", "initials": "T"}, {"family": "Holm", "given": "Johanna", "initials": "J"}, {"family": "Hanberger", "given": "H\u00e5kan", "initials": "H"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "pages": "145-151", "volume": "54", "issue": "2", "issn-l": "2374-4235"}, "abstract": "Studies from the first pandemic wave found associations between COVID-19 hospital load and mortality. Here, we aimed to study if mortality of hospitalized COVID-19 patients was associated with the COVID-19 admission rate during a full year of the pandemic in Sweden.\n\nObservational review of all patients admitted to hospital with COVID-19 in Sweden between March 2020 and February 2021 (n = 42,017). Primary outcome was 60-day all-cause mortality related to number of COVID-19 hospital admissions per month/100,000 inhabitants. Poisson regression was used to estimate the relative risk for death by month of admission, adjusting for pre-existing factors.\n\nThe overall mortality was 17.4%. Excluding March 2020, mortality was clearly correlated to the number of COVID-19 admissions per month (coefficient of correlation \u03c1=.96; p<.0001). After adjustment for pre-existing factors, the correlation remained significant (\u03c1=.75, p=.02). Patients admitted in December (high admission rate and high mortality) had more comorbidities and longer hospital stays, and patients treated in intensive care units (ICU) had longer pre-ICU hospital stays and worse respiratory status on ICU admission than those admitted in July to September (low admission rate and low mortality).\n\nMortality in hospitalized COVID-19 patients was clearly associated with the COVID-19 admission rate. Admission of healthier patients between pandemic waves and delayed ICU care during wave peaks could contribute to this pattern. The study supports measures to flatten-the-curve to reduce the number of COVID-19 patients admitted to hospital.", "doi": "10.1080/23744235.2021.1983643", "pmid": "34612774", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:27:15.805Z", "modified": "2023-01-13T13:34:39.945Z"}, {"entity": "publication", "iuid": "c37b19480dee4ac5929dad2316314ed8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c37b19480dee4ac5929dad2316314ed8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c37b19480dee4ac5929dad2316314ed8"}}, "title": "Mortality in Norway and Sweden during the COVID-19 pandemic.", "authors": [{"family": "Juul", "given": "Frederik E", "initials": "FE", "orcid": "0000-0003-3317-6988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4523958ae7f845afa749e7925890d292.json"}}, {"family": "Jodal", "given": "Henriette C", "initials": "HC", "orcid": "0000-0001-6957-9469", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6700190f6094980bc6542652f2aa833.json"}}, {"family": "Barua", "given": "Ishita", "initials": "I"}, {"family": "Refsum", "given": "Erle", "initials": "E"}, {"family": "Olsvik", "given": "\u00d8rjan", "initials": "\u00d8"}, {"family": "Helsingen", "given": "Lise M", "initials": "LM"}, {"family": "L\u00f8berg", "given": "Magnus", "initials": "M"}, {"family": "Bretthauer", "given": "Michael", "initials": "M"}, {"family": "Kalager", "given": "Mette", "initials": "M"}, {"family": "Emilsson", "given": "Louise", "initials": "L"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "38-45", "volume": "50", "issue": "1", "issn-l": "1403-4948"}, "abstract": "Background: Norway and Sweden are similar countries in terms of socioeconomics and health care. Norway implemented extensive COVID-19 measures, such as school closures and lockdowns, whereas Sweden did not. Aims: To compare mortality in Norway and Sweden, two similar countries with very different mitigation measures against COVID-19. Methods: Using real-world data from national registries, we compared all-cause and COVID-19-related mortality rates with 95% confidence intervals (CI) per 100,000 person-weeks and mortality rate ratios (MRR) comparing the five preceding years (2015-2019) with the pandemic year (2020) in Norway and Sweden. Results: In Norway, all-cause mortality was stable from 2015 to 2019 (mortality rate 14.6-15.1 per 100,000 person-weeks; mean mortality rate 14.9) and was lower in 2020 than from 2015 to 2019 (mortality rate 14.4; MRR 0.97; 95% CI 0.96-0.98). In Sweden, all-cause mortality was stable from 2015 to 2018 (mortality rate 17.0-17.8; mean mortality rate 17.1) and similar to that in 2020 (mortality rate 17.6), but lower in 2019 (mortality rate 16.2). Compared with the years 2015-2019, all-cause mortality in the pandemic year was 3% higher due to the lower rate in 2019 (MRR 1.03; 95% CI 1.02-1.04). Excess mortality was confined to people aged \u2a7e70 years in Sweden compared with previous years. The COVID-19-associated mortality rates per 100,000 person-weeks during the first wave of the pandemic were 0.3 in Norway and 2.9 in Sweden. Conclusions: All-cause mortality in 2020 decreased in Norway and increased in Sweden compared with previous years. The observed excess deaths in Sweden during the pandemic may, in part, be explained by mortality displacement due to the low all-cause mortality in the previous year.", "doi": "10.1177/14034948211047137", "pmid": "34609261", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8807990"}], "notes": [], "created": "2021-10-10T15:29:25.585Z", "modified": "2023-07-13T11:29:07.186Z"}, {"entity": "publication", "iuid": "952cfb24d67248238d32e5d03d5a3116", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/952cfb24d67248238d32e5d03d5a3116.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/952cfb24d67248238d32e5d03d5a3116"}}, "title": "Mining user reviews of COVID contact-tracing apps: An exploratory analysis of nine European apps.", "authors": [{"family": "Garousi", "given": "Vahid", "initials": "V"}, {"family": "Cutting", "given": "David", "initials": "D"}, {"family": "Felderer", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "J Syst Softw", "issn": "0164-1212", "volume": "184", "pages": "111136", "issn-l": null}, "abstract": "More than 78 countries have developed COVID contact-tracing apps to limit the spread of coronavirus. However, many experts and scientists cast doubt on the effectiveness of those apps. For each app, a large number of reviews have been entered by end-users in app stores.\n\nOur goal is to gain insights into the user reviews of those apps, and to find out the main problems that users have reported. Our focus is to assess the \"software in society\" aspects of the apps, based on user reviews.\n\nWe selected nine European national apps for our analysis and used a commercial app-review analytics tool to extract and mine the user reviews. For all the apps combined, our dataset includes 39,425 user reviews.\n\nResults show that users are generally dissatisfied with the nine apps under study, except the Scottish (\"Protect Scotland\") app. Some of the major issues that users have complained about are high battery drainage and doubts on whether apps are really working.\n\nOur results show that more work is needed by the stakeholders behind the apps (e.g., app developers, decision-makers, public health experts) to improve the public adoption, software quality and public perception of these apps.", "doi": "10.1016/j.jss.2021.111136", "pmid": "34751198", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0164-1212(21)00233-8"}, {"db": "pmc", "key": "PMC8566091"}], "notes": [], "created": "2021-11-26T15:24:59.824Z", "modified": "2021-11-26T15:24:59.858Z"}, {"entity": "publication", "iuid": "112f72343b48421da285c080bad59e9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/112f72343b48421da285c080bad59e9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/112f72343b48421da285c080bad59e9c"}}, "title": "Intensive care-treated COVID-19 patients' perception of their illness and remaining symptoms.", "authors": [{"family": "Wallin", "given": "Ewa", "initials": "E", "orcid": "0000-0003-2492-8666", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9dce246ac6b4c178c7556613294dd2b.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Rubertsson", "given": "Sten", "initials": "S"}, {"family": "Larsson", "given": "Ing-Marie", "initials": "I"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": "66", "issue": "2", "pages": "240-247"}, "abstract": "The remaining symptoms in patients with coronavirus disease 2019 (COVID-19) treated in intensive care unit are limited described. Therefore, we assessed patient's perception of their COVID-19 disease, stay in intensive care, and remaining symptoms three to six months after intensive care.\r\n\r\nProspective cohort study was performed in one intensive care unit of a university hospital in Sweden during the first wave. A questionnaire with open-ended questions and closed-ended questions was used. Data were analyzed using qualitative and quantitative content analysis and descriptive statistics.\r\n\r\nOut of 123 patients treated for COVID-19, 64 answered the questionnaire 3-6 months after discharge from intensive care. Memories from illness and hospital stay revealed in three categories; awareness of the illness, losing anchor to reality and being cared for in a dynamic environment. Information was perceived as spare by 48% and they wanted the information to be more personal. The diary was perceived as personal and was received by 33% patients. The relationship with family was affected among 39% and 13% of the patients indicated that they had not resumed their daily life. A large amount, 84%, indicated that they had remaining symptoms from COVID-19. The dominated symptoms were impaired strength and energy both physically and mentally.\r\n\r\nPatients reported a variety of physical and mental symptoms, and revealed memories from the ICU, and specific awareness of other patients' health. It illustrates the need for screening patients for remaining symptoms after COVID-19 disease and ICU care and may affect resuming patients' daily life.", "doi": "10.1111/aas.13992", "pmid": "34704256", "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pmc", "key": "PMC8653095"}], "notes": [], "created": "2021-11-01T19:42:20.654Z", "modified": "2022-02-08T19:16:01.129Z"}, {"entity": "publication", "iuid": "cfacc9763ebf480ab738d5d9b4caa532", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfacc9763ebf480ab738d5d9b4caa532.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfacc9763ebf480ab738d5d9b4caa532"}}, "title": "How children in Sweden accessed and perceived information during the first phase of the Covid-19 pandemic.", "authors": [{"family": "Rydstr\u00f6m", "given": "Lise-Lott", "initials": "LL", "orcid": "0000-0002-1007-1959", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad5251de283d4f73b0c2ac600a34a19a.json"}}, {"family": "\u00c5ngstr\u00f6m-Br\u00e4nnstr\u00f6m", "given": "Charlotte", "initials": "C"}, {"family": "Blake", "given": "Lucy", "initials": "L"}, {"family": "Brayl", "given": "Lucy", "initials": "L"}, {"family": "Carter", "given": "Bernie", "initials": "B"}, {"family": "Forsner", "given": "Maria", "initials": "M"}, {"family": "Matsson", "given": "Janet", "initials": "J"}, {"family": "Nilsson", "given": "Stefan", "initials": "S"}, {"family": "Jenholt Nolbris", "given": "Margaretha", "initials": "M", "orcid": "0000-0002-6911-1484", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f53d9c5dc5ff46149ef63e16dfa6d7a1.json"}}, {"family": "Kirton", "given": "Jennifer", "initials": "J"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "Protheroe", "given": "Joanne", "initials": "J"}, {"family": "Rullander", "given": "Anna-Clara", "initials": "AC"}, {"family": "Saron", "given": "Holly", "initials": "H"}, {"family": "Lindholm Olinder", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "144-151", "volume": "50", "issue": "1", "issn-l": "1403-4948"}, "abstract": "To describe how children in Sweden accessed and perceived information about SARS-CoV2 and Covid-19 during the first phase of the outbreak.\n\nThis study is a substudy of an international cross-sectional online mixed methods survey examining elements of children's health literacy in relation to Covid-19. The survey included multiple-choice questions, open-ended questions and drawings and collected information from 50 Swedish children (7-12 years). Data were analysed concurrently on a descriptive level using statistics and content analysis. Quantitative and qualitative data, including the drawings, were considered equally important and resulted in six categories, illuminating how children accessed and perceived information about the pandemic.\n\nThe survey showed that children accessed information mainly from school but also from TV. They preferred information from reliable sources. Children reported the information they accessed as easy to understand and it prompted them to ask new questions. They reported they knew a lot about the pandemic, for example, the potential danger to themselves and others and how to act to protect themselves and others. They perceived the pandemic as an intrusion on their lives.\n\nThis study indicates that Swedish children between 7 and 12 years old were well informed about SARS-CoV2 and Covid-19 during the first phase of the pandemic. School was shown to be an important source of information. The children could explain how to act to protect themselves and others from becoming infected by the virus.", "doi": "10.1177/14034948211051884", "pmid": "34736348", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8807992"}], "notes": [], "created": "2021-11-08T09:16:39.380Z", "modified": "2023-01-13T13:51:41.582Z"}, {"entity": "publication", "iuid": "60ee8787609f4c53af2c09abcf3a14a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60ee8787609f4c53af2c09abcf3a14a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60ee8787609f4c53af2c09abcf3a14a0"}}, "title": "Effects of the COVID-19 pandemic on the mental health of seafarers: A comparison using matched samples.", "authors": [{"family": "Pauksztat", "given": "Birgit", "initials": "B"}, {"family": "Andrei", "given": "Daniela M", "initials": "DM"}, {"family": "Grech", "given": "Michelle R", "initials": "MR"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Saf Sci", "issn": "0925-7535", "volume": "146", "pages": "105542", "issn-l": null}, "abstract": "The COVID-19 pandemic and the measures implemented to curb its transmission have altered workplaces and challenged occupational health and safety in unprecedented ways, with high levels of mental distress reported across several industries. In the maritime industry, occupational health and safety risks, including psychosocial risks, were a concern already before the COVID-19 pandemic. However, knowledge about the prevalence of mental health problems and the factors associated with them is still limited. The purpose of this study was to investigate the impact of the COVID-19 pandemic as well as the effects of respondent and work-related characteristics on seafarers' self-reported symptoms of depression and anxiety. Data came from two cross-sectional convenience samples of seafarers on international commercial vessels, surveyed before (Npre-pandemic = 793) and during the pandemic (Npandemic = 504). Matching the two samples on respondent and work-related characteristics using propensity scores, we found that the pandemic contributed to significantly higher levels of depression and anxiety. Further analyses showed that seafarers with longer work periods, those who had been on board longer than expected, and those working on vessels registered with \"Flags of Convenience\" reported significantly higher levels of both depression and anxiety during the pandemic, but not prior to the pandemic. Taken together, these findings suggest that the impact of the COVID-19 pandemic led to a deterioration of working conditions and increased mental health risks for seafarers. Practical implications for safe-guarding occupational health and safety during this and future crises are discussed.", "doi": "10.1016/j.ssci.2021.105542", "pmid": "34744311", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0925-7535(21)00385-4"}, {"db": "pmc", "key": "PMC8556536"}], "notes": [], "created": "2021-11-26T15:36:01.988Z", "modified": "2021-11-26T15:36:02.000Z"}, {"entity": "publication", "iuid": "bbd1f4a00548411baa09980def7774e3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bbd1f4a00548411baa09980def7774e3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bbd1f4a00548411baa09980def7774e3"}}, "title": "Digital communities of practice: one step towards decolonising global health partnerships.", "authors": [{"family": "Sant Fruchtman", "given": "Carmen", "initials": "C", "orcid": "0000-0002-5276-3515", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a71c19d528084816a975a3df84a7e2bc.json"}}, {"family": "Bilal Khalid", "given": "Muhammad", "initials": "M", "orcid": "0000-0003-3986-7093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5037eaca65284f5cad172d462853272d.json"}}, {"family": "Keakabetse", "given": "Tshiamo", "initials": "T", "orcid": "0000-0003-0725-0961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2309f59fae34a388d346452b97f78e5.json"}}, {"family": "Bonito", "given": "Antonio", "initials": "A"}, {"family": "Saulnier", "given": "Dell D", "initials": "DD", "orcid": "0000-0001-7761-0737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d3fc961101845b1ae844339af7495e4.json"}}, {"family": "Mupara", "given": "Lucia Mungapeyi", "initials": "LM", "orcid": "0000-0003-3497-624X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea507bc1ee1248ceb82868ff1d30fa81.json"}}, {"family": "Iqbal", "given": "Shahid", "initials": "S", "orcid": "0000-0002-9211-1212", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b0e092055ca4eb395503bb02161ef31.json"}}, {"family": "de Almeida", "given": "Afonso", "initials": "A"}, {"family": "da Silva", "given": "Hendriketa", "initials": "H"}, {"family": "de Jesus", "given": "Diamantino", "initials": "D"}, {"family": "Prytherch", "given": "Helen", "initials": "H"}, {"family": "Mokalake", "given": "Ellen", "initials": "E"}, {"family": "Cobos Mu\u00f1oz", "given": "Daniel", "initials": "D", "orcid": "0000-0002-5920-1304", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89b7c57ce7304d659ec7a077a0a841dc.json"}}, {"family": "Zafar", "given": "Shamsa", "initials": "S", "orcid": "0000-0003-4397-5505", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/880e602fe5c64b8182e075f1f17caa8c.json"}}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "7", "issue": "2", "issn-l": "2059-7908"}, "abstract": null, "doi": "10.1136/bmjgh-2021-008174", "pmid": "35110274", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-008174"}], "notes": [], "created": "2022-02-06T16:49:54.389Z", "modified": "2022-02-06T16:49:54.650Z"}, {"entity": "publication", "iuid": "a3ed4c5b77514da0a2a847afe8a47040", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3ed4c5b77514da0a2a847afe8a47040.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3ed4c5b77514da0a2a847afe8a47040"}}, "title": "Dataset: COVID-19 epidemic policy and events timeline (Sweden).", "authors": [{"family": "Olofsson", "given": "Tobias", "initials": "T"}, {"family": "Vilhelmsson", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Data Brief", "issn": "2352-3409", "volume": "40", "pages": "107698", "issn-l": null}, "abstract": "The Swedish approach to managing the 2020-2021 COVID-19 pandemic has received significant attention in international scholarly work and press. For this dataset, we have reviewed governmental and media archives to build a detailed timeline that chronicles significant policies, interventions, and events in the Swedish management of COVID-19. The dataset contains summary descriptions of what took place, when it happened, and who the principal actors involved were. Links to primary sources are provided for each entry. Because of the level of detail and saturation, the dataset offers a detailed account of Swedish pandemic governance and will benefit anyone working on Swedish pandemic management or doing comparative work between Sweden and other jurisdictions.", "doi": "10.1016/j.dib.2021.107698", "pmid": "34926743", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2352-3409(21)00973-2"}, {"db": "pmc", "key": "PMC8667349"}, {"db": "URL", "key": "https://doi.org/10.5281/zenodo.5718433", "description": "https://doi.org/10.5281/zenodo.5718433"}], "notes": [], "created": "2022-01-03T15:24:42.157Z", "modified": "2022-01-03T15:25:34.875Z"}, {"entity": "publication", "iuid": "47860632a9a641bc8cfc1e7a85fb5e30", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47860632a9a641bc8cfc1e7a85fb5e30.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47860632a9a641bc8cfc1e7a85fb5e30"}}, "title": "Compliance with recommendations limiting COVID-19 contagion among university students in Sweden: associations with self-reported symptoms, mental health and academic self-efficacy.", "authors": [{"family": "Berman", "given": "Anne H", "initials": "AH", "orcid": "0000-0002-7709-0230", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c6d87ccfe79452d920ffbe797143f38.json"}}, {"family": "Bendtsen", "given": "Marcus", "initials": "M"}, {"family": "Molander", "given": "Olof", "initials": "O"}, {"family": "Lindfors", "given": "Petra", "initials": "P"}, {"family": "Lindner", "given": "Philip", "initials": "P"}, {"family": "Granlund", "given": "Lilian", "initials": "L"}, {"family": "Topooco", "given": "Naira", "initials": "N"}, {"family": "Engstr\u00f6m", "given": "Karin", "initials": "K"}, {"family": "Andersson", "given": "Claes", "initials": "C"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": "50", "issue": "1", "pages": "70-84"}, "abstract": "The COVID-19 containment strategy in Sweden uses public health recommendations relying on personal responsibility for compliance. Universities were one of few public institutions subject to strict closure, meaning that students had to adapt overnight to online teaching. This study investigates the prevalence of self-reported recommendation compliance and associations with self-reported symptoms of contagion, self-experienced effects on mental health and academic self-efficacy among university students in Sweden in May-June 2020.\n\nThis was a cross-sectional 23 question online survey in which data were analysed by multinomial regression, taking a Bayesian analysis approach complemented by null hypothesis testing.\n\nA total of 4495 students consented to respond. Recommendation compliance ranged between 70% and 96%. Women and older students reported higher compliance than did men and younger students. Mild to moderate COVID-19 symptoms were reported by 30%, severe symptoms by fewer than 2%; 15% reported being uncertain and half of the participants reported no symptoms. Mental health effects were reported by over 80%, and changes in academic self-efficacy were reported by over 85%; in both these areas negative effects predominated. Self-reported symptoms and uncertainty about contagion were associated with non-compliance, negative mental health effects, and impaired academic self-efficacy.\n\nStudents generally followed public health recommendations during strict closure of universities, but many reported considerable negative consequences related to mental health and academic self-efficacy. Digital interventions should be developed and evaluated to boost coping skills, build resilience and alleviate student suffering during the pandemic and future similar crises.", "doi": "10.1177/14034948211027824", "pmid": "34213359", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8808007"}], "notes": [], "created": "2021-07-05T15:00:03.045Z", "modified": "2023-06-19T14:25:17.882Z"}, {"entity": "publication", "iuid": "c1f1248fa5f24349b1f8e426ec55841b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1f1248fa5f24349b1f8e426ec55841b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1f1248fa5f24349b1f8e426ec55841b"}}, "title": "Co-circulation of SARS-CoV-2 Alpha and Gamma variants in Italy, February and March 2021.", "authors": [{"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Trentini", "given": "Filippo", "initials": "F"}, {"family": "Guzzetta", "given": "Giorgio", "initials": "G"}, {"family": "Marziano", "given": "Valentina", "initials": "V"}, {"family": "Mammone", "given": "Alessia", "initials": "A"}, {"family": "Sane Schepisi", "given": "Monica", "initials": "M"}, {"family": "Poletti", "given": "Piero", "initials": "P"}, {"family": "Molina Gran\u00e9", "given": "Carla", "initials": "C"}, {"family": "Manica", "given": "Mattia", "initials": "M"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Ajelli", "given": "Marco", "initials": "M"}, {"family": "Rezza", "given": "Giovanni", "initials": "G"}, {"family": "Brusaferro", "given": "Silvio", "initials": "S"}, {"family": "Merler", "given": "Stefano", "initials": "S"}, {"family": "COVID-19 National Microbiology Surveillance Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "27", "issue": "5", "issn-l": null}, "abstract": "BackgroundSeveral SARS-CoV-2 variants of concern (VOC) have emerged through 2020 and 2021. There is need for tools to estimate the relative transmissibility of emerging variants of SARS-CoV-2 with respect to circulating strains.AimWe aimed to assess the prevalence of co-circulating VOC in Italy and estimate their relative transmissibility.MethodsWe conducted two genomic surveillance surveys on 18 February and 18 March 2021 across the whole Italian territory covering 3,243 clinical samples and developed a mathematical model that describes the dynamics of co-circulating strains.ResultsThe Alpha variant was already dominant on 18 February in a majority of regions/autonomous provinces (national prevalence: 54%) and almost completely replaced historical lineages by 18 March (dominant across Italy, national prevalence: 86%). We found a substantial proportion of the Gamma variant on 18 February, almost exclusively in central Italy (prevalence: 19%), which remained similar on 18 March. Nationally, the mean relative transmissibility of Alpha ranged at 1.55-1.57 times the level of historical lineages (95% CrI: 1.45-1.66). The relative transmissibility of Gamma varied according to the assumed degree of cross-protection from infection with other lineages and ranged from 1.12 (95% CrI: 1.03-1.23) with complete immune evasion to 1.39 (95% CrI: 1.26-1.56) for complete cross-protection.ConclusionWe assessed the relative advantage of competing viral strains, using a mathematical model assuming different degrees of cross-protection. We found substantial co-circulation of Alpha and Gamma in Italy. Gamma was not able to outcompete Alpha, probably because of its lower transmissibility.", "doi": "10.2807/1560-7917.ES.2022.27.5.2100429", "pmid": "35115077", "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-06T16:47:07.921Z", "modified": "2022-02-06T16:47:07.934Z"}, {"entity": "publication", "iuid": "657c84fe12664bbcb560de7d0549c6b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/657c84fe12664bbcb560de7d0549c6b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/657c84fe12664bbcb560de7d0549c6b2"}}, "title": "Clinical phenotypes and outcomes of SARS-CoV-2, influenza, RSV and seven other respiratory viruses: a retrospective study using complete hospital data.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P", "orcid": "0000-0003-3153-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd6af5accfc84ff9a81983a5ab6683aa.json"}}, {"family": "Karlsson Valik", "given": "John", "initials": "J"}, {"family": "van der Werff", "given": "Suzanne", "initials": "S"}, {"family": "Tanushi", "given": "Hideyuki", "initials": "H"}, {"family": "Requena Mendez", "given": "Ana", "initials": "A"}, {"family": "Granath", "given": "Fredrik", "initials": "F"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}, {"family": "Dyrdak", "given": "Robert", "initials": "R"}, {"family": "Hertting", "given": "Olof", "initials": "O"}, {"family": "F\u00e4rnert", "given": "Anna", "initials": "A"}, {"family": "Ternhag", "given": "Anders", "initials": "A"}, {"family": "Naucler", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Thorax", "issn": "1468-3296", "volume": "77", "issue": "2", "pages": "154-163", "issn-l": null}, "abstract": "An understanding of differences in clinical phenotypes and outcomes COVID-19 compared with other respiratory viral infections is important to optimise the management of patients and plan healthcare. Herein we sought to investigate such differences in patients positive for SARS-CoV-2 compared with influenza, respiratory syncytial virus (RSV) and other respiratory viruses.\n\nWe performed a retrospective cohort study of hospitalised adults and children (\u226415 years) who tested positive for SARS-CoV-2, influenza virus A/B, RSV, rhinovirus, enterovirus, parainfluenza viruses, metapneumovirus, seasonal coronaviruses, adenovirus or bocavirus in a respiratory sample at admission between 2011 and 2020.\n\nA total of 6321 adult (1721 SARS-CoV-2) and 6379 paediatric (101 SARS-CoV-2) healthcare episodes were included in the study. In adults, SARS-CoV-2 positivity was independently associated with younger age, male sex, overweight/obesity, diabetes and hypertension, tachypnoea as well as better haemodynamic measurements, white cell count, platelet count and creatinine values. Furthermore, SARS-CoV-2 was associated with higher 30-day mortality as compared with influenza (adjusted HR (aHR) 4.43, 95% CI 3.51 to 5.59), RSV (aHR 3.81, 95% CI 2.72 to 5.34) and other respiratory viruses (aHR 3.46, 95% CI 2.61 to 4.60), as well as higher 90-day mortality, ICU admission, ICU mortality and pulmonary embolism in adults. In children, patients with SARS-CoV-2 were older and had lower prevalence of chronic cardiac and respiratory diseases compared with other viruses.\n\nSARS-CoV-2 is associated with more severe outcomes compared with other respiratory viruses, and although associated with specific patient and clinical characteristics at admission, a substantial overlap precludes discrimination based on these characteristics.", "doi": "10.1136/thoraxjnl-2021-216949", "pmid": "34226206", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8260304"}, {"db": "pii", "key": "thoraxjnl-2021-216949"}], "notes": [], "created": "2021-08-06T08:46:41.794Z", "modified": "2023-06-19T14:44:08.102Z"}, {"entity": "publication", "iuid": "c7700ea76af04c2587f6db8b1e4cb614", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7700ea76af04c2587f6db8b1e4cb614.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7700ea76af04c2587f6db8b1e4cb614"}}, "title": "Can field botany be effectively taught as a distance course? Experiences and reflections from the COVID-19 pandemic.", "authors": [{"family": "Auffret", "given": "Alistair G", "initials": "AG"}, {"family": "Ekholm", "given": "Adam", "initials": "A"}, {"family": "H\u00e4m\u00e4l\u00e4inen", "given": "Aino", "initials": "A"}, {"family": "Jonsell", "given": "Mats", "initials": "M"}, {"family": "Lehto", "given": "Carl", "initials": "C"}, {"family": "Nordkvist", "given": "Michelle", "initials": "M"}, {"family": "\u00d6ckinger", "given": "Erik", "initials": "E"}, {"family": "Torstensson", "given": "Peter", "initials": "P"}, {"family": "Viketoft", "given": "Maria", "initials": "M"}, {"family": "Thor", "given": "G\u00f6ran", "initials": "G"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "AoB Plants", "issn": "2041-2851", "volume": "14", "issue": "1", "pages": "plab079", "issn-l": null}, "abstract": "The COVID-19 pandemic that started in 2020 forced a rapid change in university teaching, with large numbers of courses switching to distance learning with very little time for preparation. Courses involving many practical elements and field excursions required particular care if students were to fulfil planned learning outcomes. Here, we present our experiences in teaching field botany in 2020 and 2021. Using a range of methods and tools to introduce students to the subject, promote self-learning and reflection and give rapid and regular feedback, we were able to produce a course that allowed students to achieve the intended learning outcomes and that obtained similarly positive student evaluations to previous years. The course and its outcomes were further improved in 2021. We describe how we structured field botany as a distance course in order that we could give the best possible learning experience for the students. Finally, we reflect on how digital tools can aid teaching such subjects in the future, in a world where public knowledge of natural history is declining.", "doi": "10.1093/aobpla/plab079", "pmid": "35035870", "labels": {"Topics: Register-based research": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "plab079"}, {"db": "pmc", "key": "PMC8757578"}], "notes": [], "created": "2022-01-27T07:40:01.555Z", "modified": "2022-01-27T07:40:01.591Z"}, {"entity": "publication", "iuid": "dc69051024a24f44a2ef332f63c87a44", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dc69051024a24f44a2ef332f63c87a44.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dc69051024a24f44a2ef332f63c87a44"}}, "title": "COVID-19 among young adults in Sweden: self-reported long-term symptoms and associated factors.", "authors": [{"family": "Ekstr\u00f6m", "given": "Sandra", "initials": "S", "orcid": "0000-0002-2060-8190", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d63bc101e23740dcae35eefe950ca767.json"}}, {"family": "Andersson", "given": "Niklas", "initials": "N"}, {"family": "L\u00f6vquist", "given": "Alexandra", "initials": "A"}, {"family": "Lauber", "given": "Andr\u00e9", "initials": "A"}, {"family": "Georgelis", "given": "Antonios", "initials": "A"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E", "orcid": "0000-0002-8248-0663", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58e96082947e4752a23f322e42754097.json"}}, {"family": "Bergstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "85-93", "volume": "50", "issue": "1", "issn-l": "1403-4948"}, "abstract": "The main aim of the study was to describe self-reported symptoms of COVID-19 and examine if long-term symptoms are associated with lifestyle factors or common chronic diseases among Swedish young adults. A secondary aim was to compare the prevalence of smoking and snuff use before and during the COVID-19 pandemic.\n\nThe study population includes 1644 participants aged 23-26 years from the Swedish population-based birth cohort BAMSE. From August to November 2020, the participants answered a web questionnaire on COVID-19 symptoms, lifestyle and health. Information on tobacco use was compared against the previous study follow-up in 2016-2019.\n\nThe prevalence of suspected COVID-19 symptoms was 45.3% (n=742), and 80 of these (10.8%) reported long-term symptoms (\u2a7e4 weeks). There was no significant difference in sociodemographic or lifestyle factors in relation to the duration of suspected COVID-19 symptoms. Rhinitis, migraine and lower self-rated health before the pandemic was more common among participants with long-term symptoms. In addition, there was a tendency for higher prevalences of asthma, chronic bronchitis and depression in this group. The prevalence of smoking decreased from 18.9% before the pandemic to 14.7% during the pandemic, while snuff use increased from 12.7% to 22.4% (P<0.001).\n\nAlmost half of Swedish young adults have had symptoms of suspected COVID-19 from February up to August 2020. Among these, one out of 10 have had long-term symptoms for at least 4 weeks. Long-term symptoms of suspected COVID-19 were associated with several common chronic conditions. Smoking may have decreased during the pandemic, while snuff use may have increased.", "doi": "10.1177/14034948211025425", "pmid": "34148461", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8808012"}], "notes": [], "created": "2021-06-28T18:26:14.483Z", "modified": "2023-01-13T13:27:23.137Z"}, {"entity": "publication", "iuid": "5ece2c02daa34aa399d877bf9a35a88e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5ece2c02daa34aa399d877bf9a35a88e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5ece2c02daa34aa399d877bf9a35a88e"}}, "title": "A systems analysis of the COVID-19 pandemic response in the United Kingdom - Part 1 - The overall context.", "authors": [{"family": "Slater", "given": "David", "initials": "D"}, {"family": "Hollnagel", "given": "Erik", "initials": "E"}, {"family": "MacKinnon", "given": "Ralph", "initials": "R"}, {"family": "Sujan", "given": "Mark", "initials": "M"}, {"family": "Carson-Stevens", "given": "Andrew", "initials": "A"}, {"family": "Ross", "given": "Alistair", "initials": "A"}, {"family": "Bowie", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Saf Sci", "issn": "0925-7535", "volume": "146", "pages": "105525", "issn-l": null}, "abstract": "The most common reaction to suggesting that we could learn valuable lessons from the way the current pandemic has been/ is being handled, is to discourage the attempt; as it is suggested that it can all be done more accurately and authoritatively after the inevitable Public Inquiry (Slater, 2019). On the other hand, a more constructive approach, is to capture and understand the work that was actually done.This would include normal activities, as well as positive adaptations to challenges and failures that may have occurred. Such an approach aimed at improving what worked, rather than blaming people for what went wrong, has the potential to contribute more successfully to controlling the consequences of the current crisis. Such an approach should thus be aimed at detecting and feeding back lessons from emerging and probably unexpected behaviours and helping to design the system to adapt better to counter the effects. The science and discipline of Human Factors (HF) promotes system resilience. This can be defined as an organisation's ability to adjust its functioning before, during or after significant disturbances (such as a pandemic), enabling adaptation and operation under both anticipated and unanticipated circumstances. A \"functional\" approach methodology enables the identification of where the system and its various interdependent functions (an activity or set of activities that are required to give a certain output), could be improved and strengthened; if not immediately, at least for the future. Along these lines, suggestions for adding key resilience functions are additionally identified and outlined. The application and insights gained from this functional approach to the 2015 MERS-Cov pandemic in South Korea has been seen as contributing substantially to the effective response to the current crisis in that country (Min, submitted for publication). In this paper, we present an overarching framework for a series of projects that are planned to carry out focussed systems-based analysis to generate learning from key aspects of the COVID-19 pandemic response in the United Kingdom.", "doi": "10.1016/j.ssci.2021.105525", "pmid": "34658531", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0925-7535(21)00368-4"}, {"db": "pmc", "key": "PMC8501230"}], "notes": [], "created": "2021-10-21T05:01:44.575Z", "modified": "2021-10-21T05:01:44.589Z"}, {"entity": "publication", "iuid": "b145abeb119c458e98cbe2e264a72941", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b145abeb119c458e98cbe2e264a72941.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b145abeb119c458e98cbe2e264a72941"}}, "title": "Pain Burden in Post-COVID-19 Syndrome following Mild COVID-19 Infection.", "authors": [{"family": "Bileviciute-Ljungar", "given": "Indre", "initials": "I"}, {"family": "Norrefalk", "given": "Jan-Rickard", "initials": "JR", "orcid": "0000-0002-7070-3268", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24718b50907344ec9053bfc5d8495f19.json"}}, {"family": "Borg", "given": "Kristian", "initials": "K"}], "type": "journal article", "published": "2022-01-31", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "11", "issue": "3", "pages": "771"}, "abstract": "The global pandemic of SARS-CoV-2 has affected several hundred million people, and many infected people have suffered from a milder initial infection but have never fully recovered. This observational study investigates the pain burden in sufferers of post-COVID-19 syndrome after a milder initial infection. One hundred post-COVID-19 patients filled out questionnaires regarding sociodemographic data, previous comorbidities, present pharmacological treatment, pain intensity and pain localisation. Health-related quality of life, fatigue, emotional status, and insomnia were measured by validated questionnaires. Multiple post-COVID-19 symptoms, including post-exertional malaise, were evaluated by a symptom questionnaire. Among the 100 participants (mean age 44.5 years), 82% were women, 61% had higher education, and 56% were working full or part time. Nine participants reported previous pain or inflammatory conditions. Among the most painful sites were the head/face, chest, lower extremities, and migrating sites. Generalised pain was self-reported by 75 participants and was estimated in 50 participants. Diagnosis of fibromyalgia according to the 2016 criteria was suspected in 40 participants. Subgroup analyses indicated that comorbidities might play a role in the development of pain. In conclusion, a major part of sufferers from post-COVID-19 syndrome develop pain, and in addition to its many disabling symptoms, there is an urgent need for pain management in post-COVID-19 syndrome.", "doi": "10.3390/jcm11030771", "pmid": "35160223", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC8836662"}, {"db": "pii", "key": "jcm11030771"}], "notes": [], "created": "2022-02-17T06:10:30.240Z", "modified": "2023-06-19T15:16:34.767Z"}, {"entity": "publication", "iuid": "453141f6204344c5a19dc358dd5264bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/453141f6204344c5a19dc358dd5264bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/453141f6204344c5a19dc358dd5264bf"}}, "title": "Multi-professional Neurorehabilitation after Covid-19 Infection Should Include Assessment of Visual Function: Visual function after Covid-19 infection.", "authors": [{"family": "Johansson", "given": "Jan", "initials": "J"}, {"family": "Levi", "given": "Richard", "initials": "R"}, {"family": "Jakobsson", "given": "Maria", "initials": "M"}, {"family": "Gunnarsson", "given": "Stina", "initials": "S"}, {"family": "Samuelsson", "given": "Kersti", "initials": "K"}], "type": "journal article", "published": "2022-01-31", "journal": {"title": "Arch Rehabil Res Clin Transl", "issn": "2590-1095", "pages": "100184", "issn-l": null}, "abstract": "To report vision-related symptoms and neuro-visual clinical signs in patients approximately 4 months after discharge from hospitalization after Covid-19 infection. To report on co-existing functional and activity limitations.\n\nThe study is part of an ambi-directional population-based cohort study.\n\nAn outpatient setting in a hospital environment.\n\nPatients from a population-based cohort study including all laboratory-confirmed cases of Covid-19 admitted to hospital during a 3-month period in a health care region in Sweden. Among patients who, based on a standardized telephone interview, were identified as having persisting rehabilitation needs 4 months after discharge (n=185), several (n=57) reported vision-related symptoms. All 57 patients were invited to a neuro-visual examination. Six patients declined, six were unavailable and three did not fulfil the inclusion criteria. Thus 42 patients were included in the analysis.\n\nNot applicable.\n\nVision-related symptoms, neuro-visual function, and co-existing impairments affecting activities of daily life and participation.\n\nThirty-one percent of patients with rehabilitation needs after Covid-19 reported vision-related symptoms. Reading-related issues (73.8%), blurry vision (69.0%), and light sensitivity (66.7%) were the most common symptoms. Patients with reading-related issues showed a higher level of eye strain (p<0.001). Neuro-visual deficits were found in 83.3% of the patients, mainly concerning eye teaming (23.1%-66.7%) and eye movement (28.6%-30.8%) functions. Patients with vision-related symptoms reported fatigue and 18 other co-existing symptoms to a greater extent (p\u22640.0001 to 0.049).\n\nNeuro-visual symptoms and signs should be considered when assessing rehabilitation needs after Covid-19. The association between vision-related issues and co-existing symptoms with an impact on body function and activity/participation underlines the need for multi-professional rehabilitation assessment and intervention.", "doi": "10.1016/j.arrct.2022.100184", "pmid": "35128374", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2590-1095(22)00007-6"}, {"db": "pmc", "key": "PMC8802546"}], "notes": [], "created": "2022-02-08T15:15:20.652Z", "modified": "2022-02-08T15:15:20.658Z"}, {"entity": "publication", "iuid": "b4ec75c22fa64badaf91848a344c0ae3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b4ec75c22fa64badaf91848a344c0ae3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b4ec75c22fa64badaf91848a344c0ae3"}}, "title": "Integrated Sustainable childhood Pneumonia and Infectious disease Reduction in Nigeria (INSPIRING) through whole system strengthening in Jigawa, Nigeria: study protocol for a cluster randomised controlled trial.", "authors": [{"family": "King", "given": "Carina", "initials": "C", "orcid": "0000-0002-6885-6716", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8ac349483b74803a39b937bf149c480.json"}}, {"family": "Burgess", "given": "Rochelle Ann", "initials": "RA"}, {"family": "Bakare", "given": "Ayobami A", "initials": "AA"}, {"family": "Shittu", "given": "Funmilayo", "initials": "F"}, {"family": "Salako", "given": "Julius", "initials": "J"}, {"family": "Bakare", "given": "Damola", "initials": "D"}, {"family": "Uchendu", "given": "Obioma C", "initials": "OC"}, {"family": "Iuliano", "given": "Agnese", "initials": "A"}, {"family": "Isah", "given": "Adamu", "initials": "A"}, {"family": "Adams", "given": "Osebi", "initials": "O"}, {"family": "Haruna", "given": "Ibrahim", "initials": "I"}, {"family": "Magama", "given": "Abdullahi", "initials": "A"}, {"family": "Ahmed", "given": "Tahlil", "initials": "T"}, {"family": "Ahmar", "given": "Samy", "initials": "S"}, {"family": "Cassar", "given": "Christine", "initials": "C"}, {"family": "Valentine", "given": "Paula", "initials": "P"}, {"family": "Olowookere", "given": "Temitayo Folorunso", "initials": "TF"}, {"family": "MacCalla", "given": "Matthew", "initials": "M"}, {"family": "Graham", "given": "Hamish R", "initials": "HR"}, {"family": "McCollum", "given": "Eric D", "initials": "ED"}, {"family": "Falade", "given": "Adegoke G", "initials": "AG"}, {"family": "Colbourn", "given": "Tim", "initials": "T"}, {"family": "INSPIRING Project Consortium", "given": "", "initials": ""}], "type": "clinical trial protocol", "published": "2022-01-31", "journal": {"title": "Trials", "issn": "1745-6215", "volume": "23", "issue": "1", "pages": "95", "issn-l": null}, "abstract": "Child mortality remains unacceptably high, with Northern Nigeria reporting some of the highest rates globally (e.g. 192/1000 live births in Jigawa State). Coverage of key protect and prevent interventions, such as vaccination and clean cooking fuel use, is low. Additionally, knowledge, care-seeking and health system factors are poor. Therefore, a whole systems approach is needed for sustainable reductions in child mortality.\n\nThis is a cluster randomised controlled trial, with integrated process and economic evaluations, conducted from January 2021 to September 2022. The trial will be conducted in Kiyawa Local Government Area, Jigawa State, Nigeria, with an estimated population of 230,000. Clusters are defined as primary government health facility catchment areas (n = 33). The 33 clusters will be randomly allocated (1:1) in a public ceremony, and 32 clusters included in the impact evaluation. The trial will evaluate a locally adapted 'whole systems strengthening' package of three evidence-based methods: community men's and women's groups, Partnership Defined Quality Scorecard and healthcare worker training, mentorship and provision of basic essential equipment and commodities. The primary outcome is mortality of children aged 7 days to 59 months. Mortality will be recorded prospectively using a cohort design, and secondary outcomes measured through baseline and endline cross-sectional surveys. Assuming the following, we will have a minimum detectable effect size of 30%: (a) baseline mortality of 100 per 1000 livebirths, (b) 4480 compounds with 3 eligible children per compound, (c) 80% power, (d) 5% significance, (e) intra-cluster correlation of 0.007 and (f) coefficient of variance of cluster size of 0.74. Analysis will be by intention-to-treat, comparing intervention and control clusters, adjusting for compound and trial clustering.\n\nThis study will provide robust evidence of the effectiveness and cost-effectiveness of community-based participatory learning and action, with integrated health system strengthening and accountability mechanisms, to reduce child mortality. The ethnographic process evaluation will allow for a rich understanding of how the intervention works in this context. However, we encountered a key challenge in calculating the sample size, given the lack of timely and reliable mortality data and the uncertain impacts of the COVID-19 pandemic.\n\nISRCTN 39213655 . Registered on 11 December 2019.", "doi": "10.1186/s13063-021-05859-5", "pmid": "35101109", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13063-021-05859-5"}, {"db": "pmc", "key": "PMC8802253"}], "notes": [], "created": "2022-02-06T16:52:28.794Z", "modified": "2022-02-06T16:52:28.819Z"}, {"entity": "publication", "iuid": "4605d61423c84be6a37ba9454a1991a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4605d61423c84be6a37ba9454a1991a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4605d61423c84be6a37ba9454a1991a9"}}, "title": "Global case fatality rate of coronavirus disease 2019 (COVID-19) by continents and national income: a meta-analysis.", "authors": [{"family": "Ghayda", "given": "Ramy Abou", "initials": "RA"}, {"family": "Lee", "given": "Keum Hwa", "initials": "KH"}, {"family": "Han", "given": "Young Joo", "initials": "YJ"}, {"family": "Ryu", "given": "Seohyun", "initials": "S"}, {"family": "Hong", "given": "Sung Hwi", "initials": "SH"}, {"family": "Yoon", "given": "Sojung", "initials": "S"}, {"family": "Jeong", "given": "Gwang Hun", "initials": "GH"}, {"family": "Yang", "given": "Jae Won", "initials": "JW"}, {"family": "Lee", "given": "Hyo Jeong", "initials": "HJ"}, {"family": "Lee", "given": "Jinhee", "initials": "J"}, {"family": "Lee", "given": "Jun Young", "initials": "JY"}, {"family": "Effenberger", "given": "Maria", "initials": "M"}, {"family": "Eisenhut", "given": "Michael", "initials": "M"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Solmi", "given": "Marco", "initials": "M"}, {"family": "Li", "given": "Han", "initials": "H"}, {"family": "Jacob", "given": "Louis", "initials": "L"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Park", "given": "Myung Bae", "initials": "MB"}, {"family": "Aghayeva", "given": "Sevda", "initials": "S"}, {"family": "Ahmed", "given": "Mohamed Lemine Cheikh Brahim", "initials": "MLCB"}, {"family": "Serouri", "given": "Abdulwahed Al", "initials": "AA"}, {"family": "Al-Shamsi", "given": "Humaid O", "initials": "HO"}, {"family": "Amir-Behghadami", "given": "Mehrdad", "initials": "M"}, {"family": "Baatarkhuu", "given": "Oidov", "initials": "O"}, {"family": "Bashour", "given": "Hyam", "initials": "H"}, {"family": "Bondarenko", "given": "Anastasiia", "initials": "A"}, {"family": "Camacho-Ortiz", "given": "Adrian", "initials": "A"}, {"family": "Castro", "given": "Franz", "initials": "F"}, {"family": "Cox", "given": "Horace", "initials": "H"}, {"family": "Davtyan", "given": "Hayk", "initials": "H"}, {"family": "Douglas", "given": "Kirk", "initials": "K"}, {"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Ebrahim", "given": "Shahul", "initials": "S"}, {"family": "Ferioli", "given": "Martina", "initials": "M"}, {"family": "Harapan", "given": "Harapan", "initials": "H"}, {"family": "Mallah", "given": "Saad I", "initials": "SI"}, {"family": "Ikram", "given": "Aamer", "initials": "A"}, {"family": "Inoue", "given": "Shigeru", "initials": "S"}, {"family": "Jankovic", "given": "Slobodan", "initials": "S"}, {"family": "Jayarajah", "given": "Umesh", "initials": "U", "orcid": "0000-0002-0398-5197", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0bea00924415424fa7972f7aef4788f1.json"}}, {"family": "Jesenak", "given": "Milos", "initials": "M"}, {"family": "Kakodkar", "given": "Pramath", "initials": "P"}, {"family": "Kebede", "given": "Yohannes", "initials": "Y"}, {"family": "Kifle", "given": "Meron", "initials": "M"}, {"family": "Koh", "given": "David", "initials": "D"}, {"family": "Males", "given": "Visnja Kokic", "initials": "VK"}, {"family": "Kotfis", "given": "Katarzyna", "initials": "K"}, {"family": "Lakoh", "given": "Sulaiman", "initials": "S"}, {"family": "Ling", "given": "Lowell", "initials": "L"}, {"family": "Llibre-Guerra", "given": "Jorge", "initials": "J"}, {"family": "Machida", "given": "Masaki", "initials": "M"}, {"family": "Makurumidze", "given": "Richard", "initials": "R"}, {"family": "Mamun", "given": "Mohammed", "initials": "M", "orcid": "0000-0002-1728-8966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6e65a5a97154d159a63cc2ce3f1b7a8.json"}}, {"family": "Masic", "given": "Izet", "initials": "I"}, {"family": "Van Minh", "given": "Hoang", "initials": "H"}, {"family": "Moiseev", "given": "Sergey", "initials": "S"}, {"family": "Nadasdy", "given": "Thomas", "initials": "T"}, {"family": "Nahshon", "given": "Chen", "initials": "C"}, {"family": "\u00d1amendys-Silva", "given": "Silvio A", "initials": "SA"}, {"family": "Yongsi", "given": "Blaise Nguendo", "initials": "BN"}, {"family": "Nielsen", "given": "Henning Bay", "initials": "HB"}, {"family": "Nodjikouambaye", "given": "Zita Aleyo", "initials": "ZA"}, {"family": "Ohnmar", "given": "Ohnmar", "initials": "O"}, {"family": "Oksanen", "given": "Atte", "initials": "A", "orcid": "0000-0003-4143-5580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ad67f37abe44c1aa0e75421648cfb0d.json"}}, {"family": "Owopetu", "given": "Oluwatomi", "initials": "O"}, {"family": "Parperis", "given": "Konstantinos", "initials": "K"}, {"family": "Perez", "given": "Gonzalo Emanuel", "initials": "GE"}, {"family": "Pongpirul", "given": "Krit", "initials": "K"}, {"family": "Rademaker", "given": "Marius", "initials": "M"}, {"family": "Rosa", "given": "Sandro", "initials": "S"}, {"family": "Sah", "given": "Ranjit", "initials": "R"}, {"family": "Sallam", "given": "Dina", "initials": "D"}, {"family": "Schober", "given": "Patrick", "initials": "P"}, {"family": "Singhal", "given": "Tanu", "initials": "T"}, {"family": "Tafaj", "given": "Silva", "initials": "S"}, {"family": "Torres", "given": "Irene", "initials": "I"}, {"family": "Smith Torres-Roman", "given": "J", "initials": "J"}, {"family": "Tsartsalis", "given": "Dimitrios", "initials": "D"}, {"family": "Tsolmon", "given": "Jadamba", "initials": "J"}, {"family": "Tuychiev", "given": "Laziz", "initials": "L"}, {"family": "Vukcevic", "given": "Batric", "initials": "B"}, {"family": "Wanghi", "given": "Guy", "initials": "G"}, {"family": "Wollina", "given": "Uwe", "initials": "U"}, {"family": "Xu", "given": "Ren-He", "initials": "R"}, {"family": "Yang", "given": "Lin", "initials": "L"}, {"family": "Zaidi", "given": "Zoubida", "initials": "Z"}, {"family": "Smith", "given": "Lee", "initials": "L"}, {"family": "Shin", "given": "Jae Il", "initials": "JI", "orcid": "0000-0003-2326-1820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ca450cb43e3478d81ba93be745f0ea0.json"}}], "type": "journal article", "published": "2022-01-31", "journal": {"title": "J Med Virol", "issn": "1096-9071", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The aim of this study is to provide a more accurate representation of COVID-19's CFR by performing meta-analyses by continents and income, and by comparing the result with pooled estimates. We used multiple worldwide data sources on COVID-19 for every country reporting COVID-19 cases. Based on the data, we performed random and fixed meta-analyses for CFR of COVID-19 by continents and income according to each individual calendar date. CFR were estimated based on the different geographical regions and level of income using three models: pooled estimates, fixed- and random-model. In Asia, all three types of CFR initially remained approximately between 2.0% and 3.0%. In the case of pooled estimates and the fixed model results, CFR increased to 4.0%, by then gradually decreasing, while in the case of random-model, CFR remained under 2.0%. Similarly, in Europe, initially the two types of CFR peaked at 9.0% and 10.0%, respectively. The random-model results showed an increase near 5.0%. In high income countries, pooled estimates and fixed-model showed gradually increasing trends with a final pooled estimates and random-model reached about 8.0% and 4.0%, respectively. In middle-income, the pooled estimates and fixed-model have gradually increased reaching up to 4.5%. in low-income countries, CFRs remained similar between 1.5% and 3.0%. Our study emphasizes that COVID-19 CFR is not a fixed or static value. Rather, it is a dynamic estimate that changes with time, population, socioeconomic factors and the mitigatory efforts of individuals countries. This article is protected by copyright. All rights reserved.", "doi": "10.1002/jmv.27610", "pmid": "35099819", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-06T16:54:07.571Z", "modified": "2022-02-06T16:54:40.249Z"}, {"entity": "publication", "iuid": "05cec7cdf3064c9c9162018fddda120d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/05cec7cdf3064c9c9162018fddda120d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/05cec7cdf3064c9c9162018fddda120d"}}, "title": "Evaluation serum levels of Insulin Growth Factor-1 (IGF-1) and its association with clinical parameters in severe COVID-19.", "authors": [{"family": "Feizollahi", "given": "Parisa", "initials": "P"}, {"family": "Matin", "given": "Somaieh", "initials": "S"}, {"family": "Roghani", "given": "Seyed Askar", "initials": "SA"}, {"family": "Mostafaei", "given": "Shayan", "initials": "S"}, {"family": "Safarzadeh", "given": "Elham", "initials": "E"}, {"family": "Taghadosi", "given": "Mahdi", "initials": "M", "orcid": "0000-0002-3516-0130", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f30112bc6d6140479d16934f5223e9a4.json"}}], "type": "journal article", "published": "2022-01-31", "journal": {"title": "Inflammopharmacology", "issn": "1568-5608", "issn-l": null}, "abstract": "Severe coronavirus disease-2019 (COVID-19) is associated with dysregulated immune response and extreme inflammatory injury. Considering the role of insulin growth factor-1 (IGF-1) in immune-mediated and inflammatory reactions, this study was conducted to investigate the IGF-1 contribution to the pathogenesis of severe form of COVID-19.\n\nSixty-two patients with severe COVID-19 and 52 healthy subjects were enrolled in this study. The serum levels of IGF-1 were measured using a solid-phase enzyme-linked chemiluminescent immunoassay on an Immulite 2000 system (Siemens Healthcare Diagnostics.\n\nThe serum levels of IGF-1 had no significant difference in COVID-19 patients compared to the healthy subjects (p = 0.359). There was a positive correlation between IGF-1 and age in the severe COVID-19 patients, while a negative correlation was observed for the serum levels of IGF-1 and age in the control group (r = 0.364, p = 0.036, r = - 0.536, p = 0.001, respectively). Moreover, IGF-1 was remarkably associated with hypertension, neurogenic disease, shock, and nausea in patients with the severe form of COVID-19 (p = 0.031, p = 0.044, p = 0.01, p = 0.03, respectively).\n\nOur results pointed to the complex role of IGF-1 in the severe form of COVID-19, and its association with clinical parameters, and some risk factors in the severe form of COVID-19.", "doi": "10.1007/s10787-021-00908-6", "pmid": "35098386", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10787-021-00908-6"}, {"db": "pmc", "key": "PMC8801278"}], "notes": [], "created": "2022-02-06T16:55:44.236Z", "modified": "2022-02-06T16:55:44.304Z"}, {"entity": "publication", "iuid": "b56709f19e1e42c5b849ae05e968851d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b56709f19e1e42c5b849ae05e968851d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b56709f19e1e42c5b849ae05e968851d"}}, "title": "Bacterial co-infections in community-acquired pneumonia caused by SARS-CoV-2, influenza virus and respiratory syncytial virus.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P"}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Ternhag", "given": "Anders", "initials": "A"}, {"family": "Abdel-Halim", "given": "Lina", "initials": "L"}, {"family": "Hedlund", "given": "Jonas", "initials": "J"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2022-01-31", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "volume": "22", "issue": "1", "pages": "108", "issn-l": null}, "abstract": "A mismatch between a widespread use of broad-spectrum antibiotic agents and a low prevalence of reported bacterial co-infections in patients with SARS-CoV-2 infections has been observed. Herein, we sought to characterize and compare bacterial co-infections at admission in hospitalized patients with SARS-CoV-2, influenza or respiratory syncytial virus (RSV) positive community-acquired pneumonia (CAP).\n\nA retrospective cohort study of bacterial co-infections at admission in SARS-CoV-2, influenza or RSV-positive adult patients with CAP admitted to Karolinska University Hospital in Stockholm, Sweden, from year 2011 to 2020. The prevalence of bacterial co-infections was investigated and compared between the three virus groups. In each virus group, length of stay, ICU-admission and 30-day mortality was compared in patients with and without bacterial co-infection, adjusting for age, sex and co-morbidities. In the SARS-CoV-2 group, risk factors for bacterial co-infection, were assessed using logistic regression models and creation of two scoring systems based on disease severity, age, co-morbidities and inflammatory markers with assessment of concordance statistics.\n\nCompared to influenza and RSV, the bacterial co-infection testing frequency in SARS-CoV-2 was lower for all included test modalities. Four percent [46/1243 (95% CI 3-5)] of all SARS-CoV-2 patients had a bacterial co-infection at admission, whereas the proportion was 27% [209/775 (95% CI 24-30)] and 29% [69/242 (95% CI 23-35)] in influenza and RSV, respectively. S. pneumoniae and S. aureus constituted the most common bacterial findings for all three virus groups. Comparing SARS-CoV-2 positive patients with and without bacterial co-infection at admission, a relevant association could not be demonstrated nor excluded with regards to risk of ICU-admission (aHR 1.53, 95% CI 0.87-2.69) or 30-day mortality (aHR 1.28, 95% CI 0.66-2.46) in adjusted analyses. Bacterial co-infection was associated with increased inflammatory markers, but the diagnostic accuracy was not substantially different in a scoring system based on disease severity, age, co-morbidities and inflammatory parameters [C statistic 0.66 (95% CI 0.59-0.74)], compared to using disease severity, age and co-morbidities only [C statistic 0.63 (95% CI 0.56-0.70)].\n\nThe prevalence of bacterial co-infections was significantly lower in patients with community-acquired SARS-CoV-2 positive pneumonia as compared to influenza and RSV positive pneumonia.", "doi": "10.1186/s12879-022-07089-9", "pmid": "35100984", "labels": {"Category: Health": null, "Type: Journal article": null, "Funder: Vinnova": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12879-022-07089-9"}, {"db": "pmc", "key": "PMC8802536"}], "notes": [], "created": "2022-02-06T16:52:51.200Z", "modified": "2022-02-06T16:53:31.048Z"}, {"entity": "publication", "iuid": "a5fae45113934b8bb907e66a3b263b48", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a5fae45113934b8bb907e66a3b263b48.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a5fae45113934b8bb907e66a3b263b48"}}, "title": "Assessing How Consumers Interpret and Act on Results From At-Home COVID-19 Self-test Kits: A Randomized Clinical Trial.", "authors": [{"family": "Woloshin", "given": "Steven", "initials": "S"}, {"family": "Dewitt", "given": "Barry", "initials": "B"}, {"family": "Krishnamurti", "given": "Tamar", "initials": "T"}, {"family": "Fischhoff", "given": "Baruch", "initials": "B"}], "type": "journal article", "published": "2022-01-31", "journal": {"title": "JAMA Intern Med", "issn": "2168-6114", "issn-l": null}, "abstract": "The US Food and Drug Administration (FDA) authorized SARS-CoV-2 rapid at-home self-test kits for individuals with and without symptoms. How appropriately users interpret and act on the results of at-home COVID-19 self-tests is unknown.\n\nTo assess how users of at-home COVID-19 self-test kits interpret and act on results when given instructions authorized by the FDA, instructions based on decision science principles, or no instructions.\n\nA randomized clinical trial was conducted of 360 adults in the US who were recruited in April 2021 to complete an online survey on their interpretation of at-home COVID-19 self-test results. Participants were given 1 of 3 instruction types and were presented with 1 of 4 risk scenarios. Participants were paid $5 and had a median survey completion time of 8.7 minutes. Data analyses were performed from June to July 2021.\n\nParticipants were randomized to receiving either the FDA-authorized instructions (authorized), the intervention instructions (intervention), or no instructions (control), and to 1 of 4 scenarios: 3 with a high pretest probability of infection (COVID-19 symptoms and/or a close contact with COVID-19) and 1 with low pretest probability (no symptoms and no contact). The intervention instructions were designed using decision science principles.\n\nProportion of participants in the high pretest probability scenarios choosing to quarantine per federal recommendations and perceived probabilities of infection given a negative or positive COVID-19 test result. A Bonferroni correction accounted for multiple comparisons (3 instruction types \u00d7 4 scenarios; \u03b1 = 0.004).\n\nAfter excluding 22 individuals who completed the survey too quickly, the responses of 338 participants (median [IQR] age, 38 [31 to 48] years; 154 (46%) women; 215 (64%) with a college degree or higher) were included in the study analysis. Given a positive test result, 95% (322 of 338; 95% CI, 0.92 to 0.97) of the total participants appropriately chose to quarantine regardless of which instructions they had received. Given a negative test result, participants in the high pretest probability scenarios were more likely to fail to quarantine appropriately with the authorized instructions (33%) than with the intervention (14%; 95% CI for the 19% difference, 6% to 31%; P = .004) or control (24%; 95% CI for the 9% difference, -4% to 23%; P = .02). In the low pretest probability scenario, the proportion choosing unnecessary quarantine was higher with the authorized instructions (31%) than with the intervention (22%; 95% CI for the 9% difference, -14% to 31%) or control (10%; 95% CI for the 21% difference, 0.5% to 41%)-neither comparison was statistically significant (P = .05 and P = .20 respectively).\n\nThe findings of this randomized clinical trial indicate that at-home COVID-19 self-test kit users relying on the authorized instructions may not follow the Centers for Disease Control and Prevention's quarantine recommendations, producing unintended risks and unnecessary disruptions. Redesigned instructions that follow decision science principles may improve compliance.\n\nClinicalTrials.gov Identifier: NCT04758299.", "doi": "10.1001/jamainternmed.2021.8075", "pmid": "35099501", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "2788656"}, {"db": "ClinicalTrials.gov", "key": "NCT04758299"}], "notes": [], "created": "2022-02-06T16:54:52.435Z", "modified": "2022-02-06T16:55:06.381Z"}, {"entity": "publication", "iuid": "93039f55bd154261b34650b56b1ce76f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/93039f55bd154261b34650b56b1ce76f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/93039f55bd154261b34650b56b1ce76f"}}, "title": "An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection.", "authors": [{"family": "Sanchez-Burgos", "given": "Laura", "initials": "L"}, {"family": "G\u00f3mez-L\u00f3pez", "given": "Gonzalo", "initials": "G"}, {"family": "Al-Shahrour", "given": "F\u00e1tima", "initials": "F"}, {"family": "Fernandez-Capetillo", "given": "Oscar", "initials": "O"}], "type": "journal article", "published": "2022-01-31", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "12", "issue": "1", "pages": "1626"}, "abstract": "The ongoing COVID-19 pandemic is one of the biggest health challenges of recent decades. Among the causes of mortality triggered by SARS-CoV-2 infection, the development of an inflammatory \"cytokine storm\" (CS) plays a determinant role. Here, we used transcriptomic data from the bronchoalveolar lavage fluid (BALF) of COVID-19 patients undergoing a CS to obtain gene-signatures associated to this pathology. Using these signatures, we interrogated the Connectivity Map (CMap) dataset that contains the effects of over 5000 small molecules on the transcriptome of human cell lines, and looked for molecules which effects on transcription mimic or oppose those of the CS. As expected, molecules that potentiate immune responses such as PKC activators are predicted to worsen the CS. In addition, we identified the negative regulation of female hormones among pathways potentially aggravating the CS, which helps to understand the gender-related differences in COVID-19 mortality. Regarding drugs potentially counteracting the CS, we identified glucocorticoids as a top hit, which validates our approach as this is the primary treatment for this pathology. Interestingly, our analysis also reveals a potential effect of MEK inhibitors in reverting the COVID-19 CS, which is supported by in vitro data that confirms the anti-inflammatory properties of these compounds.", "doi": "10.1038/s41598-022-05597-x", "pmid": "35102208", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-05597-x"}], "notes": [], "created": "2022-02-04T16:00:23.387Z", "modified": "2022-02-04T16:02:21.636Z"}, {"entity": "publication", "iuid": "fe7406372e8d41658b99738bd1fd23cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fe7406372e8d41658b99738bd1fd23cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fe7406372e8d41658b99738bd1fd23cc"}}, "title": "Seek COVER: using a disease proxy to rapidly develop and validate a personalized risk calculator for COVID-19 outcomes in an international network.", "authors": [{"family": "Williams", "given": "Ross D", "initials": "RD"}, {"family": "Markus", "given": "Aniek F", "initials": "AF"}, {"family": "Yang", "given": "Cynthia", "initials": "C"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "DuVall", "given": "Scott L", "initials": "SL"}, {"family": "Falconer", "given": "Thomas", "initials": "T"}, {"family": "Jonnagaddala", "given": "Jitendra", "initials": "J"}, {"family": "Kim", "given": "Chungsoo", "initials": "C"}, {"family": "Rho", "given": "Yeunsook", "initials": "Y"}, {"family": "Williams", "given": "Andrew E", "initials": "AE"}, {"family": "Machado", "given": "Amanda Alberga", "initials": "AA"}, {"family": "An", "given": "Min Ho", "initials": "MH"}, {"family": "Arag\u00f3n", "given": "Mar\u00eda", "initials": "M"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Burn", "given": "Edward", "initials": "E"}, {"family": "Choi", "given": "Young Hwa", "initials": "YH"}, {"family": "Drakos", "given": "Iannis", "initials": "I"}, {"family": "Abrah\u00e3o", "given": "Maria Tereza Fernandes", "initials": "MTF"}, {"family": "Fern\u00e1ndez-Bertol\u00edn", "given": "Sergio", "initials": "S"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Kaas-Hansen", "given": "Benjamin Skov", "initials": "BS"}, {"family": "Kandukuri", "given": "Prasanna L", "initials": "PL"}, {"family": "Kors", "given": "Jan A", "initials": "JA"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Liaw", "given": "Siaw-Teng", "initials": "ST"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Machnicki", "given": "Gerardo", "initials": "G"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Morales", "given": "Daniel", "initials": "D"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Park", "given": "Rae Woong", "initials": "RW"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A"}, {"family": "Pratt", "given": "Nicole", "initials": "N"}, {"family": "Rao", "given": "Gowtham", "initials": "G"}, {"family": "Reich", "given": "Christian G", "initials": "CG"}, {"family": "Rivera", "given": "Marcela", "initials": "M"}, {"family": "Seinen", "given": "Tom", "initials": "T"}, {"family": "Shoaibi", "given": "Azza", "initials": "A"}, {"family": "Spotnitz", "given": "Matthew E", "initials": "ME"}, {"family": "Steyerberg", "given": "Ewout W", "initials": "EW"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhou", "given": "Lili", "initials": "L"}, {"family": "Ryan", "given": "Patrick B", "initials": "PB"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Reps", "given": "Jenna M", "initials": "JM"}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR"}], "type": "journal article", "published": "2022-01-30", "journal": {"title": "BMC Med Res Methodol", "issn": "1471-2288", "volume": "22", "issue": "1", "pages": "35", "issn-l": null}, "abstract": "We investigated whether we could use influenza data to develop prediction models for COVID-19 to increase the speed at which prediction models can reliably be developed and validated early in a pandemic. We developed COVID-19 Estimated Risk (COVER) scores that quantify a patient's risk of hospital admission with pneumonia (COVER-H), hospitalization with pneumonia requiring intensive services or death (COVER-I), or fatality (COVER-F) in the 30-days following COVID-19 diagnosis using historical data from patients with influenza or flu-like symptoms and tested this in COVID-19 patients.\n\nWe analyzed a federated network of electronic medical records and administrative claims data from 14 data sources and 6 countries containing data collected on or before 4/27/2020. We used a 2-step process to develop 3 scores using historical data from patients with influenza or flu-like symptoms any time prior to 2020. The first step was to create a data-driven model using LASSO regularized logistic regression, the covariates of which were used to develop aggregate covariates for the second step where the COVER scores were developed using a smaller set of features. These 3 COVER scores were then externally validated on patients with 1) influenza or flu-like symptoms and 2) confirmed or suspected COVID-19 diagnosis across 5 databases from South Korea, Spain, and the United States. Outcomes included i) hospitalization with pneumonia, ii) hospitalization with pneumonia requiring intensive services or death, and iii) death in the 30 days after index date.\n\nOverall, 44,507 COVID-19 patients were included for model validation. We identified 7 predictors (history of cancer, chronic obstructive pulmonary disease, diabetes, heart disease, hypertension, hyperlipidemia, kidney disease) which combined with age and sex discriminated which patients would experience any of our three outcomes. The models achieved good performance in influenza and COVID-19 cohorts. For COVID-19 the AUC ranges were, COVER-H: 0.69-0.81, COVER-I: 0.73-0.91, and COVER-F: 0.72-0.90. Calibration varied across the validations with some of the COVID-19 validations being less well calibrated than the influenza validations.\n\nThis research demonstrated the utility of using a proxy disease to develop a prediction model. The 3 COVER models with 9-predictors that were developed using influenza data perform well for COVID-19 patients for predicting hospitalization, intensive services, and fatality. The scores showed good discriminatory performance which transferred well to the COVID-19 population. There was some miscalibration in the COVID-19 validations, which is potentially due to the difference in symptom severity between the two diseases. A possible solution for this is to recalibrate the models in each location before use.", "doi": "10.1186/s12874-022-01505-z", "pmid": "35094685", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8801189"}, {"db": "pii", "key": "10.1186/s12874-022-01505-z"}], "notes": [], "created": "2022-02-06T17:04:47.177Z", "modified": "2023-06-19T15:02:04.233Z"}, {"entity": "publication", "iuid": "5ff0cd52aeff4d118b9046cb52f729a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5ff0cd52aeff4d118b9046cb52f729a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5ff0cd52aeff4d118b9046cb52f729a9"}}, "title": "The experiences of early career geriatricians throughout Europe during the COVID-19 pandemic.", "authors": [{"family": "Mezera", "given": "Vojtech", "initials": "V", "orcid": "0000-0002-8679-5208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53a0de0cbddb4ee8b35b5c6302159732.json"}}, {"family": "Ekdahl", "given": "Anne W", "initials": "AW"}, {"family": "Bertschi", "given": "Dominic", "initials": "D"}, {"family": "Bonnici", "given": "Maria", "initials": "M"}, {"family": "Buzaco", "given": "Rui", "initials": "R"}, {"family": "Rodeles", "given": "Santiago Cotobal", "initials": "SC"}, {"family": "Eruslanova", "given": "Kseniia", "initials": "K"}, {"family": "Matchekhina", "given": "Lubov", "initials": "L"}, {"family": "Bazan", "given": "Laura Monica Perez", "initials": "LMP"}, {"family": "Epelde", "given": "Itxaso Marin", "initials": "IM"}, {"family": "Kotsani", "given": "Marina", "initials": "M"}, {"family": "Femminella", "given": "Grazia Daniela", "initials": "GD"}, {"family": "Koca", "given": "Meltem", "initials": "M"}, {"family": "Dejaeger", "given": "Marian", "initials": "M"}], "type": "journal article", "published": "2022-01-29", "journal": {"title": "Eur Geriatr Med", "issn": "1878-7649", "issn-l": null}, "abstract": "The COVID-19 pandemic has severely affected older adults and brought about unprecedented challenges to geriatricians. We aimed to evaluate the experiences of early career geriatricians (residents or consultants with up to 10 years of experience) throughout Europe using an online survey. We obtained 721 responses. Most of the respondents were females (77.8%) and residents in geriatric medicine (54.6%). The majority (91.4%) were directly involved in the care of patients with COVID-19. The respondents reported moderate levels of anxiety and feelings of being overloaded with work. The anxiety levels were higher in women than in men. Most of the respondents experienced a feeling of a strong restriction on their private lives and a change in their work routine. The residents also reported a moderate disruption in their training and research activities. In conclusion, early career geriatricians experienced a major impact of COVID-19 on their professional and private lives.", "doi": "10.1007/s41999-021-00605-1", "pmid": "35091891", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s41999-021-00605-1"}], "notes": [], "created": "2022-01-31T11:42:19.651Z", "modified": "2022-01-31T11:42:19.721Z"}, {"entity": "publication", "iuid": "98c961ceb77b450cbb159b7679a93ff0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/98c961ceb77b450cbb159b7679a93ff0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/98c961ceb77b450cbb159b7679a93ff0"}}, "title": "The impact of Covid-19 on the initiation of clinical trials in Europe and the United States.", "authors": [{"family": "Lasch", "given": "Florian", "initials": "F"}, {"family": "Psarelli", "given": "Eftychia-Eirini", "initials": "EE"}, {"family": "Herold", "given": "Ralf", "initials": "R"}, {"family": "Mattsson", "given": "Andrea", "initials": "A"}, {"family": "Guizzaro", "given": "Lorenzo", "initials": "L"}, {"family": "P\u00e9tavy", "given": "Frank", "initials": "F"}, {"family": "Schiel", "given": "Anja", "initials": "A"}], "type": "journal article", "published": "2022-01-28", "journal": {"title": "Clin Pharmacol Ther", "issn": "1532-6535", "issn-l": null}, "abstract": "The Covid-19 pandemic has a major impact not only on public health and daily living, but also on clinical trials worldwide. To investigate the potential impact of the Covid-19 pandemic on the initiation of clinical trials, we have descriptively analysed the longitudinal change in phase II and III interventional clinical trials initiated in Europe and in the United States. Based on the public clinical trial register EU Clinical Trials Register and clinicaltrials.gov, we conducted (a) a yearly comparison of the number of initiated trials from 2010 to 2020 and (b) a monthly comparison from January 2020 to February 2021 of the number of initiated trials. The analyses indicate that the Covid-19 pandemic affected both the initiation of clinical trials overall and the initiation of non-Covid-19 trials. An increase in the overall numbers of clinical trials could be observed both in Europe and the US in 2020 as compared to 2019. However, the number of non-Covid-19 trials initiated is reduced as compared to the previous decade, with a slightly larger relative decrease in the US as compared to Europe. Additionally, the monthly trend for the initiation of non-Covid-19 trials differs between regions. In the US, after a sharp decrease in April 2020, trial numbers reached the levels of 2019 from June 2020 onwards. In Europe, the decrease was less pronounced, but trial numbers mainly remained below the 2019 average until February 2021.", "doi": "10.1002/cpt.2534", "pmid": "35090044", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-31T11:43:04.018Z", "modified": "2022-01-31T11:43:04.042Z"}, {"entity": "publication", "iuid": "f26455ac99bd45c1a392a3fbd85b2979", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f26455ac99bd45c1a392a3fbd85b2979.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f26455ac99bd45c1a392a3fbd85b2979"}}, "title": "Social Skills Group Training for Students with Neurodevelopmental Disabilities in Senior High School-A Qualitative Multi-Perspective Study of Social Validity.", "authors": [{"family": "Leifler", "given": "Emma", "initials": "E", "orcid": "0000-0001-5007-0996", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61adfbe1d8e64ceab6c076053cb6ad94.json"}}, {"family": "Coco", "given": "Christina", "initials": "C", "orcid": "0000-0001-7963-8637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29565879a0ef4cb088318d41df64b633.json"}}, {"family": "Fridell", "given": "Anna", "initials": "A"}, {"family": "Borg", "given": "Anna", "initials": "A"}, {"family": "B\u00f6lte", "given": "Sven", "initials": "S"}], "type": "journal article", "published": "2022-01-28", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "3", "issn-l": null}, "abstract": "Including students with neurodevelopmental disabilities (NDDs) in regular classrooms has become a law-enforced common practice in many high- and middle-income countries. Still, without appropriate actions supporting the implementation of inclusive pedagogical practice, students with NDDs remain at increased risk for absenteeism, bullying and underachievement. There is limited knowledge on the feasibility of social skills group training (SSGT) in naturalistic settings. Using a qualitative approach, the objective of this study was to explore the lived experiences of (i) students diagnosed with autism or attention-deficit hyperactivity disorder and those showing subclinical social difficulties receiving either SSGT or active social control activities in a regular senior high school setting, (ii) teachers providing SSGT or the active control activity and (iii) school leaders facilitating the implementation of these actions. Due to the impact of the COVID-19 pandemic, comparison between real life versus digital administration of SSGT was also examined. Within a randomized controlled pilot trial of the school-tailored SSGT SKOLKONTAKT\u00ae, the primary perspectives of 20 students, teachers and school leaders on SSGT or the social control activities were explored. All groups perceived SSGT to enhance school attendance and academic achievement of students, as well as teacher inclusion skills and the social school climate. Findings indicate that SSGT is largely feasible and socially valid, and broader implementation of SSGT in school settings appears meaningful.", "doi": "10.3390/ijerph19031487", "pmid": "35162512", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph19031487"}], "notes": [], "created": "2022-02-17T06:09:18.094Z", "modified": "2022-02-17T06:09:18.193Z"}, {"entity": "publication", "iuid": "c9bcbac993ca42218a2c39ff2598c89c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9bcbac993ca42218a2c39ff2598c89c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9bcbac993ca42218a2c39ff2598c89c"}}, "title": "Inherited IFNAR1 Deficiency in a Child with Both Critical COVID-19 Pneumonia and Multisystem Inflammatory Syndrome.", "authors": [{"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Landegren", "given": "Nils", "initials": "N"}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Materna", "given": "Marie", "initials": "M"}, {"family": "Modaresi", "given": "Mohammadreza", "initials": "M"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Aranda-Guill\u00e9n", "given": "Maribel", "initials": "M"}, {"family": "Sardh", "given": "Fabian", "initials": "F"}, {"family": "Zuo", "given": "Fanglei", "initials": "F"}, {"family": "Zhang", "given": "Peng", "initials": "P"}, {"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Marr", "given": "Nico", "initials": "N"}, {"family": "Khan", "given": "Taushif", "initials": "T"}, {"family": "Ata", "given": "Manar", "initials": "M"}, {"family": "Al-Ali", "given": "Fatima", "initials": "F"}, {"family": "Pescarmona", "given": "Remi", "initials": "R"}, {"family": "Belot", "given": "Alexandre", "initials": "A"}, {"family": "B\u00e9ziat", "given": "Vivien", "initials": "V"}, {"family": "Zhang", "given": "Qian", "initials": "Q"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL"}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q", "orcid": "0000-0003-1990-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94a32366862b470eba3a15521b9be290.json"}}], "type": "journal article", "published": "2022-01-28", "journal": {"title": "J Clin Immunol", "issn": "1573-2592", "issn-l": "0271-9142"}, "abstract": "Inborn errors of immunity (IEI) and autoantibodies to type I interferons (IFNs) underlie critical COVID-19 pneumonia in at least 15% of the patients, while the causes of multisystem inflammatory syndrome in children (MIS-C) remain elusive.\n\nTo detect causal genetic variants in very rare cases with concomitant critical COVID-19 pneumonia and MIS-C.\n\nWhole exome sequencing was performed, and the impact of candidate gene variants was investigated. Plasma levels of cytokines, specific antibodies against the virus, and autoantibodies against type I IFNs were also measured.\n\nWe report a 3-year-old child who died on day 56 of SARS-CoV-2 infection with an unusual clinical presentation, combining both critical COVID-19 pneumonia and MIS-C. We identified a large, homozygous loss-of-function deletion in IFNAR1, underlying autosomal recessive IFNAR1 deficiency.\n\nOur findings confirm that impaired type I IFN immunity can underlie critical COVID-19 pneumonia, while suggesting that it can also unexpectedly underlie concomitant MIS-C. Our report further raises the possibility that inherited or acquired dysregulation of type I IFN immunity might contribute to MIS-C in other patients.", "doi": "10.1007/s10875-022-01215-7", "pmid": "35091979", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10875-022-01215-7"}], "notes": [], "created": "2022-01-31T11:41:50.645Z", "modified": "2022-01-31T11:41:50.669Z"}, {"entity": "publication", "iuid": "2de0e4d64ed54d4380102d6aba32653b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2de0e4d64ed54d4380102d6aba32653b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2de0e4d64ed54d4380102d6aba32653b"}}, "title": "Corrigendum to \"Error rates in SARS-CoV-2 testing examined with Bayes' theorem\" [Heliyon 7 (4), (April 2021) Article e06905].", "authors": [{"family": "Bentley", "given": "Phillip", "initials": "P"}], "type": "published erratum", "published": "2022-01-28", "journal": {"title": "Heliyon", "issn": "2405-8440", "pages": "e08836", "issn-l": null}, "abstract": "[This corrects the article DOI: 10.1016/j.heliyon.2021.e06905.].", "doi": "10.1016/j.heliyon.2022.e08836", "pmid": "35106385", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(22)00124-4"}, {"db": "pmc", "key": "PMC8795781"}], "notes": [], "created": "2022-02-06T16:50:42.414Z", "modified": "2022-02-06T16:50:42.429Z"}, {"entity": "publication", "iuid": "00f475c5a60449c68afa511f7dbbf937", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/00f475c5a60449c68afa511f7dbbf937.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/00f475c5a60449c68afa511f7dbbf937"}}, "title": "Social Work Responses to Domestic Violence During the COVID-19 Pandemic: Experiences and Perspectives of Professionals at Women's Shelters in Sweden.", "authors": [{"family": "Petersson", "given": "Charlotte C", "initials": "CC", "orcid": "0000-0002-2233-9297", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bef9293d9cfa49fb99a23232e1f8905e.json"}}, {"family": "Hansson", "given": "Kristofer", "initials": "K"}], "type": "journal article", "published": "2022-01-27", "journal": {"title": "Clin Soc Work J", "issn": "0091-1674", "issn-l": null, "volume": null, "issue": null, "pages": "1-12"}, "abstract": "This study explores how social work professionals at women's shelters in Sweden experience, understand, and are responding to domestic violence under the impact of the COVID-19 pandemic. A qualitative longitudinal research design was employed, and multiple semi-structured interviews were conducted with 14 professionals at women's shelters over a period of one year. The results are presented in three overall themes; (a) professional challenges due to increased needs, (b) professionals' adjustments to new circumstances, and (c) professionals' attributions regarding client barriers to help seeking. The results show diverse and changing experiences among the professionals as the pandemic progressed. Clients and professionals have shared the same collective trauma associated with the pandemic, which has affected the professionals' understanding of and response to domestic violence. The professionals understand both clients and themselves as being more vulnerable and susceptible to risk under these new circumstances. Social work adjustments focused on maintaining contact, reducing risk and prioritizing safety, which had both positive and negative consequences for both clients and professionals. The study concludes that the professionals coped with the uncertainty they experienced during the pandemic by relying on both their previous knowledge and work experience of domestic violence and their experience of sharing trauma with clients.", "doi": "10.1007/s10615-022-00833-3", "pmid": "35103027", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "833"}, {"db": "pmc", "key": "PMC8792516"}], "notes": [], "created": "2022-02-06T16:51:49.489Z", "modified": "2022-11-22T05:40:09.771Z"}, {"entity": "publication", "iuid": "393d6100ca964841b76331c427e6aa0c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/393d6100ca964841b76331c427e6aa0c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/393d6100ca964841b76331c427e6aa0c"}}, "title": "Risk factors for COVID-19-related death, hospitalization and intensive care: a population-wide study of all inhabitants in Stockholm.", "authors": [{"family": "Hergens", "given": "Maria-Pia", "initials": "MP"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "Haglund", "given": "Per", "initials": "P"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Lampa", "given": "Erik", "initials": "E"}, {"family": "Nederby-\u00d6hd", "given": "Joanna", "initials": "J"}, {"family": "\u00d6stlund", "given": "Maria Rotz\u00e9n", "initials": "MR"}, {"family": "Cars", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2022-01-27", "journal": {"title": "Eur J Epidemiol", "issn": "1573-7284", "issn-l": "0393-2990"}, "abstract": "Since the beginning of the Covid-19 pandemic, the scientific community has explored determinants of Covid 19 disease severity. However, the majority of studies are based on in-hospital patients with high risk of collider- or selection bias. The present investigation details risk factors associated with overall mortality, hospitalization and intensive care unit (ICU) admission in Covid-19 infections, with complete population coverage and high-resolution data on patient characteristics and comorbid conditions This population-based observational study comprises all residents 18 years and older in Stockholm Region-1.8 million inhabitants-using the real-time Covid-19 monitoring framework. The observation period lasted between March 1 to December 31, 2020. Hazard ratios (HR) for risk factors of Covid-19 disease severity were assessed using Cox proportional hazard models. In total, 3322 deaths, 11,508 hospitalizations and 1423 ICU-admissions related to Covid-19 occurred during the study period. Kidney failure, diabetes and obesity increased risk of mortality and so did heart failure and ischemic heart disease. However, atrial fibrillation and hypertension did not. Risk of hospitalization follow a similar pattern, whereas admission to intensive care differs; triage processes where clearly present as certain co-morbid conditions were associated with lower ICU admission. Observed differences in risk of mortality and hospitalization among patients with Covid 19 raise important questions about potentially protective comedication which will be further addressed using the real-time Covid-19 monitoring framework.", "doi": "10.1007/s10654-021-00840-7", "pmid": "35083602", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10654-021-00840-7"}, {"db": "pmc", "key": "PMC8791671"}], "notes": [], "created": "2022-01-31T11:48:07.605Z", "modified": "2022-01-31T11:48:07.617Z"}, {"entity": "publication", "iuid": "983a90975b164a94803529dc4a7b9691", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/983a90975b164a94803529dc4a7b9691.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/983a90975b164a94803529dc4a7b9691"}}, "title": "Humoral immunogenicity and tolerability of heterologous ChAd/BNT compared with homologous BNT/BNT and ChAd/ChAd SARS-CoV-2 vaccination in hemodialysis patients : A multicenter prospective observational study.", "authors": [{"family": "Haase", "given": "Michael", "initials": "M", "orcid": "0000-0001-8212-7416", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3d5795641ee4ff0ab46f79603ba5e73.json"}}, {"family": "Lesny", "given": "Paul", "initials": "P", "orcid": "0000-0003-3001-5257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fd70d53d0644bbca442128b4bbdd676.json"}}, {"family": "Anderson", "given": "Mark", "initials": "M"}, {"family": "Cloherty", "given": "Gavin", "initials": "G"}, {"family": "Stec", "given": "Michael", "initials": "M"}, {"family": "Haase-Fielitz", "given": "Anja", "initials": "A", "orcid": "0000-0001-6881-2249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/281cb6db938041329bca7a38c27e39cd.json"}}, {"family": "Haarhaus", "given": "Mathias", "initials": "M", "orcid": "0000-0001-8274-6356", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b32fbbc042844a8a43fa0ab3dda8557.json"}}, {"family": "Santos-Ara\u00fajo", "given": "Carla", "initials": "C"}, {"family": "Veiga", "given": "Pedro Mota", "initials": "PM"}, {"family": "Macario", "given": "Fernando", "initials": "F"}], "type": "journal article", "published": "2022-01-27", "journal": {"title": "J Nephrol", "issn": "1724-6059", "issn-l": null}, "abstract": "After the reports of severe adverse reactions to the AstraZeneca ChAdOx1-S-nCoV-19 vaccine, patients who had received one dose of ChAdOx1-S-nCoV-19 vaccine were recommended a second dose of Pfizer's BNT162b2 vaccine. In hemodialysis patients, we compared the humoral immunogenicity and tolerability of homologous vaccination with ChAdOx1-nCoV-19/ChAdOx1-nCoV-19 (ChAd/ChAd) and BNT162b2/BNT162b2 (BNT/BNT) with heterologous vaccination of first dose of ChAdOx1-nCoV-19 and a second dose with BNT162b2 (ChAd/BNT).\n\nIn a multicenter prospective observational study, SARS-CoV-2 spike-IgG antibody levels, Nucleocapsid-protein-IgG-antibodies, and vaccine tolerability were assessed 6 weeks after second SARS-CoV-2 vaccination in 137 hemodialysis patients and 24 immunocompetent medical personnel.\n\nIn COVID-19-na\u00efve hemodialysis patients, significantly higher median SARS-CoV-2-spike IgG levels were found after ChAd/BNT (N = 16) compared to BNT/BNT (N = 100) or ChAd/ChAd (N = 10) (1744 [25th-75th percentile 276-2840] BAU/mL versus 361 [25th-75th percentile 120-936] BAU/mL; p = 0.009; 1744 [25th-75th percentile 276-2840] BAU/mL versus 100 [25th-75th percentile 41-346] BAU/mL; p = 0.017, respectively). Vaccinated, COVID-19-na\u00efve medical personnel had median SARS-CoV-2 spike-IgG levels of 650 (25th-75th percentile 217-1402) BAU/mL and vaccinated hemodialysis patients with prior COVID-19 7047 (25th-75th percentile 685-10,794) BAU/mL (N = 11). In multivariable regression analysis, heterologous vaccination (ChAd/BNT) of COVID-19-na\u00efve hemodialysis patients was independently associated with SARS-CoV-2 spike-IgG levels. The first dose of ChAd and the second dose of BNT after the first vaccination with ChAd (heterologous vaccination, ChAd/BNT) were associated with more frequent but manageable side effects compared with homologous BNT.\n\nWithin the limitations of this study, heterologous vaccination with ChAd/BNT appears to induce stronger humoral immunity and more frequent but manageable side effects than homologous vaccination with BNT/BNT or with ChAd/ChAd in COVID-19-na\u00efve hemodialysis patients.", "doi": "10.1007/s40620-022-01247-7", "pmid": "35084719", "labels": {"Category: Health": null, "Category: Other": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40620-022-01247-7"}, {"db": "pmc", "key": "PMC8792133"}], "notes": [], "created": "2022-01-31T11:45:33.489Z", "modified": "2022-01-31T11:45:33.628Z"}, {"entity": "publication", "iuid": "0524427e04e14e1396474c73d00bf50d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0524427e04e14e1396474c73d00bf50d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0524427e04e14e1396474c73d00bf50d"}}, "title": "National identity predicts public health support during a global pandemic.", "authors": [{"family": "Van Bavel", "given": "Jay J", "initials": "JJ", "orcid": "0000-0002-2520-0442", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/344fbd5da7bc4259b3f70839f401c84c.json"}}, {"family": "Cichocka", "given": "Aleksandra", "initials": "A", "orcid": "0000-0003-1703-1586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0cc1202c8fb34d07952c7d99ab43bf87.json"}}, {"family": "Capraro", "given": "Valerio", "initials": "V"}, {"family": "Sj\u00e5stad", "given": "Hallgeir", "initials": "H", "orcid": "0000-0002-8730-1038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9d4b3d4379f4e3bb43607c0ef08f159.json"}}, {"family": "Nezlek", "given": "John B", "initials": "JB", "orcid": "0000-0003-4963-3637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab0b925a3d5b4c3d9f03d141757d41ba.json"}}, {"family": "Pavlovi\u0107", "given": "Tomislav", "initials": "T", "orcid": "0000-0002-4470-3715", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b5a5d7b53914f58ba60821e70539887.json"}}, {"family": "Alfano", "given": "Mark", "initials": "M", "orcid": "0000-0001-5879-8033", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9adf19b051647d19c86bc89ee440988.json"}}, {"family": "Gelfand", "given": "Michele J", "initials": "MJ"}, {"family": "Azevedo", "given": "Flavio", "initials": "F", "orcid": "0000-0001-9000-8513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7864cb0e9bf846d6b69a6a5bf65cbd91.json"}}, {"family": "Birtel", "given": "Mich\u00e8le D", "initials": "MD"}, {"family": "Cislak", "given": "Aleksandra", "initials": "A", "orcid": "0000-0002-9880-6947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37e0b6640a76467890fed6a7975b031c.json"}}, {"family": "Lockwood", "given": "Patricia L", "initials": "PL", "orcid": "0000-0001-7195-9559", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d77d4779b0ff456b906f2001dc3aa36f.json"}}, {"family": "Ross", "given": "Robert Malcolm", "initials": "RM", "orcid": "0000-0001-8711-1675", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49cb2e4d713844729ee7d64213f3cdbe.json"}}, {"family": "Abts", "given": "Koen", "initials": "K", "orcid": "0000-0001-8546-8347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9128fa7c6104fecabd5e4e52b1ce6ee.json"}}, {"family": "Agadullina", "given": "Elena", "initials": "E", "orcid": "0000-0002-1505-1412", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1d55ff13a5b4373abb3aca1376a41b9.json"}}, {"family": "Aruta", "given": "John Jamir Benzon", "initials": "JJB", "orcid": "0000-0003-4155-1063", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc1b14a0e89b4d9cb7f9c977e34a9a67.json"}}, {"family": "Besharati", "given": "Sahba Nomvula", "initials": "SN", "orcid": "0000-0003-2836-7982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8948fcda91f444f89cc8ddcfe4e489d9.json"}}, {"family": "Bor", "given": "Alexander", "initials": "A", "orcid": "0000-0002-2624-9221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/048bdb252beb4b2599b619f41ace6277.json"}}, {"family": "Choma", "given": "Becky L", "initials": "BL"}, {"family": "Crabtree", "given": "Charles David", "initials": "CD", "orcid": "0000-0001-5144-8671", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4437f3c146f4f649e796f32d01d6052.json"}}, {"family": "Cunningham", "given": "William A", "initials": "WA"}, {"family": "De", "given": "Koustav", "initials": "K", "orcid": "0000-0001-9562-0672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d6627eccf1d42baa44ed1ab89430f41.json"}}, {"family": "Ejaz", "given": "Waqas", "initials": "W", "orcid": "0000-0002-2492-4115", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0540fea51e3740068aa543e3e9bfd57e.json"}}, {"family": "Elbaek", "given": "Christian T", "initials": "CT", "orcid": "0000-0002-7039-4565", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a44f489ddccb4a208ec453424a471bfc.json"}}, {"family": "Findor", "given": "Andrej", "initials": "A", "orcid": 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{"family": "Vieira", "given": "Joana B", "initials": "JB"}, {"family": "von Sikorski", "given": "Christian", "initials": "C", "orcid": "0000-0002-3787-8277", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bacd3f29f5ff4a93a75fa018974f0d49.json"}}, {"family": "Walker", "given": "Alexander Cameron", "initials": "AC", "orcid": "0000-0003-1431-6770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e48ea603420489e9ad84494d2266981.json"}}, {"family": "Watermeyer", "given": "Jennifer", "initials": "J", "orcid": "0000-0001-7918-8832", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/361039a0f7cb4ad1ba265ac819f61df3.json"}}, {"family": "Wetter", "given": "Erik", "initials": "E"}, {"family": "Whillans", "given": "Ashley", "initials": "A", "orcid": "0000-0002-1726-6978", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/23afeb4b16404c9fbbb5aec95295e358.json"}}, {"family": "Willardt", "given": "Robin", "initials": "R", "orcid": "0000-0002-2495-3450", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5379e789ed5f4144a062b66ca92e60b7.json"}}, {"family": "Wohl", "given": "Michael J A", "initials": "MJA", "orcid": "0000-0001-6945-5562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/669ce114edff4deca4595eac19f30eda.json"}}, {"family": "W\u00f3jcik", "given": "Adrian Dominik", "initials": "AD", "orcid": "0000-0002-7073-6019", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b96aa00cd81f466599febb11c10a3a99.json"}}, {"family": "Wu", "given": "Kaidi", "initials": "K", "orcid": "0000-0001-6881-7437", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab83e58b6bcb415ea5079ac48c77dd7b.json"}}, {"family": "Yamada", "given": "Yuki", "initials": "Y", "orcid": "0000-0003-1431-568X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12d5285132e14b7bbca2607a084fb449.json"}}, {"family": "Yilmaz", "given": "Onurcan", "initials": "O", "orcid": "0000-0002-6094-7162", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/534f37d570044b1f885ebc4c7e9bab54.json"}}, {"family": "Yogeeswaran", "given": "Kumar", "initials": "K"}, {"family": "Ziemer", "given": "Carolin-Theresa", "initials": "CT", "orcid": "0000-0002-0794-7702", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8177b1e630c54506b665af61a4204f3c.json"}}, {"family": "Zwaan", "given": "Rolf A", "initials": "RA"}, {"family": "Boggio", "given": "Paulo S", "initials": "PS"}], "type": "journal article", "published": "2022-01-26", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "517", "issn-l": "2041-1723"}, "abstract": "Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N = 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r = -0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics.", "doi": "10.1038/s41467-021-27668-9", "pmid": "35082277", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-27668-9"}], "notes": [], "created": "2022-01-31T11:49:07.063Z", "modified": "2022-01-31T11:49:27.807Z"}, {"entity": "publication", "iuid": "c02cba320d9d41c1b0f2f13d26ac7fc9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c02cba320d9d41c1b0f2f13d26ac7fc9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c02cba320d9d41c1b0f2f13d26ac7fc9"}}, "title": "Investigating the current environmental situation in the Middle East and North Africa (MENA) region during the third wave of COVID-19 pandemic: urban vs. rural context.", "authors": [{"family": "Abouzid", "given": "Mohamed", "initials": "M"}, {"family": "El-Sherif", "given": "Dina M", "initials": "DM"}, {"family": "Al Naggar", "given": "Yahya", "initials": "Y"}, {"family": "Alshehri", "given": "Mohammed M", "initials": "MM"}, {"family": "Alothman", "given": "Shaima", "initials": "S"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}, {"family": "Trabelsi", "given": "Rayhana", "initials": "R"}, {"family": "Ibrahim", "given": "Osama Mohamed", "initials": "OM"}, {"family": "Temraz", "given": "Esraa Hamouda", "initials": "EH"}, {"family": "Buimsaedah", "given": "Ahmad", "initials": "A"}, {"family": "Aziz", "given": "Ibrahim Adel", "initials": "IA"}, {"family": "Alwan", "given": "Muhammad", "initials": "M"}, {"family": "Al Hasan", "given": "Nuha Hadi Jasim", "initials": "NHJ"}, {"family": "Ragab", "given": "Heba Nasser", "initials": "HN"}, {"family": "Koraiem", "given": "Abdullah Muhammed", "initials": "AM"}, {"family": "Ahmed", "given": "Mareb H", "initials": "MH"}, {"family": "Temraz", "given": "Heba Hamouda", "initials": "HH"}, {"family": "Madeeh", "given": "Alyaa Khaled", "initials": "AK"}, {"family": "Alshareif", "given": "Mohanned Osama", "initials": "MO"}, {"family": "Elkhafeefi", "given": "Fatimah Saad", "initials": "FS"}, {"family": "Badis", "given": "Imed-Eddine", "initials": "IE"}, {"family": "Abdelslam", "given": "Asmaa E", "initials": "AE"}, {"family": "Ali", "given": "Almajdoub Ali Mohammed", "initials": "AAM"}, {"family": "Kotni", "given": "Nour El Imene", "initials": "NEI"}, {"family": "Amer", "given": "Thuraya", "initials": "T"}], "type": "journal article", "published": "2022-01-26", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "177", "issn-l": null}, "abstract": "Coronavirus 2019 (COVID-19) pandemic led to a massive global socio-economic tragedy that has impacted the ecosystem. This paper aims to contextualize urban and rural environmental situations during the COVID-19 pandemic in the Middle East and North Africa (MENA) Region.\n\nAn online survey was conducted, 6770 participants were included in the final analysis, and 64% were females. The majority of the participants were urban citizens (74%). Over 50% of the urban residents significantly (p < 0.001) reported a reduction in noise, gathering in tourist areas, and gathering in malls and restaurants. Concerning the pollutants, most urban and rural areas have reported an increase in masks thrown in streets (69.49% vs. 73.22%, resp.; p = 0.003). Plastic bags and hospital waste also increased significantly with the same p-value of < 0.001 in urban areas compared with rural ones. The multifactorial logistic model for urban resident predictors achieved acceptable discrimination (AUROC = 0.633) according to age, crowdedness, noise and few pollutants.\n\nThe COVID-19 pandemic had a beneficial impact on the environment and at the same time, various challenges regarding plastic and medical wastes are rising which requires environmental interventions.", "doi": "10.1186/s12889-021-12313-3", "pmid": "35081927", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-12313-3"}, {"db": "pmc", "key": "PMC8790551"}], "notes": [], "created": "2022-01-31T11:49:45.217Z", "modified": "2022-01-31T11:49:45.246Z"}, {"entity": "publication", "iuid": "dd12a80548b54077976f107f7b65cf6d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dd12a80548b54077976f107f7b65cf6d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dd12a80548b54077976f107f7b65cf6d"}}, "title": "Computational Analysis Reveals Monomethylated Triazolopyrimidine as a Novel Inhibitor of SARS-CoV-2 RNA-Dependent RNA Polymerase (RdRp).", "authors": [{"family": "Karthic", "given": "Anandakrishnan", "initials": "A"}, {"family": "Kesarwani", "given": "Veerbhan", "initials": "V", "orcid": "0000-0001-5778-6831", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c0f527583f94625bb9d2106104fb7d2.json"}}, {"family": "Singh", "given": "Rahul Kunwar", "initials": "RK", "orcid": "0000-0003-3630-5706", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02f5d3fe155541d1b88e8c90ba420ab3.json"}}, {"family": "Yadav", "given": "Pavan Kumar", "initials": "PK"}, {"family": "Chaturvedi", "given": "Navaneet", "initials": "N", "orcid": "0000-0002-4265-9255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b6f5bf7d4ff4477b7e35faac4df684c.json"}}, {"family": "Chauhan", "given": "Pallavi", "initials": "P", "orcid": "0000-0002-5160-6673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6f59a01303e4493393dbe2fba6b2e8f7.json"}}, {"family": "Yadav", "given": "Brijesh Singh", "initials": "BS"}, {"family": "Kushwaha", "given": "Sandeep Kumar", "initials": "SK"}], "type": "journal article", "published": "2022-01-26", "journal": {"title": "Molecules", "issn": "1420-3049", "volume": "27", "issue": "3", "issn-l": null}, "abstract": "The human population is still facing appalling conditions due to several outbreaks of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus. The absence of specific drugs, appropriate vaccines for mutants, and knowledge of potential therapeutic agents makes this situation more difficult. Several 1, 2, 4-triazolo [1, 5-a] pyrimidine (TP)-derivative compounds were comprehensively studied for antiviral activities against RNA polymerase of HIV, HCV, and influenza viruses, and showed immense pharmacological interest. Therefore, TP-derivative compounds can be repurposed against the RNA-dependent RNA polymerase (RdRp) protein of SARS-CoV-2. In this study, a meta-analysis was performed to ensure the genomic variability and stability of the SARS-CoV-2 RdRp protein. The molecular docking of natural and synthetic TP compounds to RdRp and molecular dynamic (MD) simulations were performed to analyse the dynamic behaviour of TP compounds at the active site of the RdRp protein. TP compounds were also docked against other non-structural proteins (NSP1, NSP2, NSP3, NSP5, NSP8, NSP13, and NSP15) of SARS-CoV-2. Furthermore, the inhibition potential of TP compounds was compared with Remdesivir and Favipiravir drugs as a positive control. Additionally, TP compounds were analysed for inhibitory activity against SARS-CoV RdRp protein. This study demonstrates that TP analogues (monomethylated triazolopyrimidine and essramycin) represent potential lead molecules for designing an effective inhibitor to control viral replication. Furthermore, in vitro and in vivo studies will strengthen the use of these inhibitors as suitable drug candidates against SARS-CoV-2.", "doi": "10.3390/molecules27030801", "pmid": "35164069", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "molecules27030801"}], "notes": [], "created": "2022-02-17T06:08:36.632Z", "modified": "2022-02-17T06:09:00.719Z"}, {"entity": "publication", "iuid": "cf59a3c7e7c34226b242a79239cb1c2b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cf59a3c7e7c34226b242a79239cb1c2b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cf59a3c7e7c34226b242a79239cb1c2b"}}, "title": "Living conditions, lifestyle habits and health among adults before and after the COVID-19 pandemic outbreak in Sweden - results from a cross-sectional population-based study.", "authors": [{"family": "Molarius", "given": "Anu", "initials": "A"}, {"family": "Persson", "given": "Carina", "initials": "C"}], "type": "journal article", "published": "2022-01-25", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "171", "issn-l": null}, "abstract": "Studies on the public health consequences of COVID-19 pandemic showing data based on robust methods are scarce. The aim of this study was to investigate mental and physical health as well as living conditions and lifestyle habits in the general population before and after the COVID-19 outbreak in Sweden.\n\nThe study is based on 2273 persons 16-84 years who responded to the national public health survey in February-May 2020 in V\u00e4rmland county (overall response rate 45%). The differences between early respondents (before the outbreak, n = 1711) and late respondents (after the outbreak, n = 562) were studied using multivariate logistic regression, adjusting for background characteristics: age, gender, educational level, and country of birth. The same analyses were also completed in the corresponding survey carried out in February-June 2018.\n\nStatistically significant differences between the groups were obtained for economic difficulties and worry about losing one's job, which were more common among late respondents, and for sleeping difficulties, which were more common among early respondents after adjusting for background characteristics. There were no differences in other living conditions nor in lifestyle factors. Prevalence of good self-rated health, high blood pressure, aches in shoulders or neck, anxiety or worry and stress did not differ between the groups. In 2018, the only statistically significant difference between early and late respondents concerned economic difficulties.\n\nVery few differences in living conditions, lifestyle factors and health were observed in the study population before and after the COVID-19 outbreak. The results suggest that, in addition to a possible decrease in sleeping difficulties, the prevalence of being worried about losing one's job increased among the employed after the outbreak.", "doi": "10.1186/s12889-021-12315-1", "pmid": "35078430", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-12315-1"}, {"db": "pmc", "key": "PMC8787439"}], "notes": [], "created": "2022-01-27T06:59:44.489Z", "modified": "2022-01-31T11:50:19.633Z"}, {"entity": "publication", "iuid": "84fdbc5f70264da68f79b41a55046bae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84fdbc5f70264da68f79b41a55046bae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84fdbc5f70264da68f79b41a55046bae"}}, "title": "Effectiveness of tobacco cessation interventions for different groups of tobacco users in Sweden: a study protocol for a national prospective cohort study.", "authors": [{"family": "Rasmussen", "given": "Mette", "initials": "M", "orcid": "0000-0003-2847-1544", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/155367945a2f4bb186320d69eea6a117.json"}}, {"family": "Larsson", "given": "Matz", "initials": "M"}, {"family": "Gilljam", "given": "Hans", "initials": "H"}, {"family": "Adami", "given": "Johanna", "initials": "J"}, {"family": "W\u00e4rjerstam", "given": "Sanne", "initials": "S"}, {"family": "Post", "given": "Ann", "initials": "A"}, {"family": "Bj\u00f6rk-Eriksson", "given": "Thomas", "initials": "T"}, {"family": "Helgason", "given": "Asgeir R", "initials": "AR"}, {"family": "T\u00f8nnesen", "given": "Hanne", "initials": "H"}], "type": "journal article", "published": "2022-01-25", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "1", "pages": "e053090", "issn-l": "2044-6055"}, "abstract": "Tobacco is still one of the single most important risk factors among the lifestyle habits that cause morbidity and mortality in humans. Furthermore, tobacco has a heavy social gradient, as the consequences are even worse among disadvantaged and vulnerable groups. To reduce tobacco-related inequity in health, those most in need should be offered the most effective tobacco cessation intervention. The aim of this study is to facilitate and improve the evaluation of already implemented national tobacco cessation efforts, focusing on 10 disadvantaged and vulnerable groups of tobacco users.\n\nThis is a prospective cohort study. Data will be collected by established tobacco cessation counsellors in Sweden. The study includes adult tobacco or e-cigarette users, including disadvantaged and vulnerable patients, receiving in-person interventions for tobacco or e-cigarette cessation (smoking, snus and/or e-cigarettes). Patient inclusion was initiated in April 2020. For data analyses patients will be sorted into vulnerable groups based on risk factors and compared with tobacco users without the risk factor in question.The primary outcome is continuous successful quitting after 6 months, measured by self-reporting. Secondary outcomes include abstinence at the end of the treatment programme, which could be from minutes over days to weeks, 14-day point prevalence after 6 months, and patient satisfaction with the intervention. Effectiveness of successful quitting will be examined by comparing vulnerable with non-vulnerable patients using a mixed-effect logistic regression model adjusting for potential prognostic factors and known confounders.\n\nThe project will follow the guidelines from the Swedish Data Protection Authority and have been approved by the Swedish Ethical Review Authority before patient inclusion (Dnr: 2019-02221). Only patients providing written informed consent will be included. Both positive and negative results will be published in scientific peer-reviewed journals and presented at national and international conferences. Information will be provided through media available to the public, politicians, healthcare providers and planners as these are all important stakeholders.\n\nNCT04819152.", "doi": "10.1136/bmjopen-2021-053090", "pmid": "35078840", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-053090"}, {"db": "ClinicalTrials.gov", "key": "NCT04819152"}], "notes": [], "created": "2022-01-27T06:59:16.941Z", "modified": "2022-01-31T11:50:05.070Z"}, {"entity": "publication", "iuid": "b6b72a9a8e9f447b858546ce4f87518e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b6b72a9a8e9f447b858546ce4f87518e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b6b72a9a8e9f447b858546ce4f87518e"}}, "title": "Correction for Rando et al., \"Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure\".", "authors": [{"family": "Rando", "given": "Halie M", "initials": "HM", "orcid": "0000-0001-7688-1770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b5a9f4ec1bd48579abca9895dab3ea7.json"}}, {"family": "MacLean", "given": "Adam L", "initials": "AL", "orcid": "0000-0003-0689-7907", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c26b86f5b6704c6bb26549e40cb2a1a6.json"}}, {"family": "Lee", "given": "Alexandra J", "initials": "AJ", "orcid": "0000-0002-0208-3730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/761782ce14b542078b3ee6c0db2bb6ce.json"}}, {"family": "Lordan", "given": "Ronan", "initials": "R", "orcid": "0000-0001-9668-3368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0126a49dfcdf49fcb53041fbdcd91706.json"}}, {"family": "Ray", "given": "Sandipan", "initials": "S", "orcid": "0000-0002-9960-5768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa10e3ee0fd54ba493cbe4cca8fc6eff.json"}}, {"family": "Bansal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-0944-7226", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae5fbe58965d4d2ca9051acb7d654def.json"}}, {"family": "Skelly", "given": "Ashwin N", "initials": "AN", "orcid": "0000-0002-1565-3376", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9818ecec2a65431faf931d73ea71bcb2.json"}}, {"family": "Sell", "given": "Elizabeth", "initials": "E", "orcid": "0000-0002-9658-1107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8da837618164c6e95e39ec75771917c.json"}}, {"family": "Dziak", "given": "John J", "initials": "JJ", "orcid": "0000-0003-0762-5495", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7cab03612a54c61b5f336726df5fd86.json"}}, {"family": "Shinholster", "given": "Lamonica", "initials": "L", "orcid": "0000-0001-6285-005X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/55c5da8c3c764c3fbc5877f15931f19b.json"}}, {"family": "D'Agostino McGowan", "given": "Lucy", "initials": "L", "orcid": "0000-0001-7297-9359", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eaf0882d7094646bd20be91a897cf8f.json"}}, {"family": "Ben Guebila", "given": "Marouen", "initials": "M", "orcid": "0000-0001-5934-966X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e04fc9008f7f4307a76515f913f19adf.json"}}, {"family": "Wellhausen", "given": "Nils", "initials": "N", "orcid": "0000-0001-8955-7582", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/934767f0228241648d70c7b00527deff.json"}}, {"family": "Knyazev", "given": "Sergey", "initials": "S", "orcid": "0000-0003-0385-1831", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5191e5ac40f244369f156171f69b6043.json"}}, {"family": "Boca", "given": "Simina M", "initials": "SM", "orcid": "0000-0002-1400-3398", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3eb0ffeffea24d5cb745b5ca86648e60.json"}}, {"family": "Capone", "given": "Stephen", "initials": "S", "orcid": "0000-0001-7231-1535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e5465fb84654d2d8edc152bc1fabb0a.json"}}, {"family": "Qi", "given": "Yanjun", "initials": "Y", "orcid": "0000-0002-5796-7453", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d48badb4eff4f4f9bf3f15632f0c3a7.json"}}, {"family": "Park", "given": "YoSon", "initials": "Y", "orcid": "0000-0002-0465-4744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d3c095fe591449a8c122645bf540ed5.json"}}, {"family": "Mai", "given": "David", "initials": "D", "orcid": "0000-0002-9238-0164", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c9a0a9f7fd0402b889577876833cb01.json"}}, {"family": "Sun", "given": "Yuchen", "initials": "Y"}, {"family": "Boerckel", "given": "Joel D", "initials": "JD", "orcid": "0000-0003-3126-3025", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c5b796936cf42d7a3ea63f54266f680.json"}}, {"family": "Brueffer", "given": "Christian", "initials": "C", "orcid": "0000-0002-3826-0989", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c4f95c1889f4f098676404aec6125ca.json"}}, {"family": "Byrd", "given": "James Brian", "initials": "JB", "orcid": "0000-0002-0509-3520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bc319c5d0d74676875bd9ff266f5e80.json"}}, {"family": "Kamil", "given": "Jeremy P", "initials": "JP", "orcid": "0000-0001-8422-7656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa225803435a4d7b803176e2ccfbef19.json"}}, {"family": "Wang", "given": "Jinhui", "initials": "J", "orcid": "0000-0002-5796-8130", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5243fdc11744ba89697e8fdf9c2feee.json"}}, {"family": "Velazquez", "given": "Ryan", "initials": "R", "orcid": "0000-0002-3655-3403", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32443d060ec043e59e1683db8be8a2f0.json"}}, {"family": "Szeto", "given": "Gregory L", "initials": "GL", "orcid": "0000-0001-7604-1333", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ca2a47e8bce54293918ec2bec05b0cd0.json"}}, {"family": "Barton", "given": "John P", "initials": "JP", "orcid": "0000-0003-1467-421X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae8b1b4348b5476fa268c2079c6b9c7d.json"}}, {"family": "Goel", "given": "Rishi Raj", "initials": "RR", "orcid": "0000-0003-1715-5191", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ad2f4cb84774051bb9422f314ec0f11.json"}}, {"family": "Mangul", "given": "Serghei", "initials": "S", "orcid": "0000-0003-4770-3443", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dbe15e382e84d38a0fd859377e39d47.json"}}, {"family": "Lubiana", "given": "Tiago", "initials": "T", "orcid": "0000-0003-2473-2313", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/132869d486e241dda1448ef1448ab83c.json"}}, {"family": "COVID-19 Review Consortium", "given": "", "initials": ""}, {"family": "Gitter", "given": "Anthony", "initials": "A", "orcid": "0000-0002-5324-9833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7085c8743e3442859ad6f23198c85456.json"}}, {"family": "Greene", "given": "Casey S", "initials": "CS", "orcid": "0000-0001-8713-9213", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42aaaac8b65642538f28f9cd2045ab8d.json"}}], "type": "journal article", "published": "2022-01-25", "journal": {"title": "mSystems", "issn": "2379-5077", "pages": "e0144721", "issn-l": null}, "abstract": null, "doi": "10.1128/msystems.01447-21", "pmid": "35076276", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2022-01-26T08:23:59.651Z", "modified": "2022-01-26T08:24:00.210Z"}, {"entity": "publication", "iuid": "bafbb26351e0441bafd8aa7de38cd297", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bafbb26351e0441bafd8aa7de38cd297.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bafbb26351e0441bafd8aa7de38cd297"}}, "title": "A patient satisfaction survey and educational package to improve the care of people hospitalised with COVID-19: a quality improvement project, Liverpool, UK.", "authors": [{"family": "Ahmad", "given": "Muhammad Shamsher", "initials": "MS"}, {"family": "Hicks", "given": "Scott Rory", "initials": "SR"}, {"family": "Watson", "given": "Rebecca", "initials": "R"}, {"family": "Ahmed", "given": "Rajia Akter", "initials": "RA"}, {"family": "Jones", "given": "Lewis", "initials": "L"}, {"family": "Vaselli", "given": "Marcella", "initials": "M"}, {"family": "Wu", "given": "Meng-San", "initials": "MS"}, {"family": "Hayat", "given": "Fatima", "initials": "F"}, {"family": "Ratcliffe", "given": "Libuse", "initials": "L"}, {"family": "McKenna", "given": "Mark", "initials": "M"}, {"family": "Hine", "given": "Paul", "initials": "P"}, {"family": "Defres", "given": "Sylviane", "initials": "S"}, {"family": "Wingfield", "given": "Tom", "initials": "T"}], "type": "journal article", "published": "2022-01-25", "journal": {"title": "Wellcome Open Res", "issn": "2398-502X", "volume": "6", "pages": "222", "issn-l": null}, "abstract": "Background: The perspectives and experiences of people hospitalised with COVID-19 have been under-reported during the coronavirus pandemic. We developed and conducted a COVID-19 patient satisfaction survey in a large university-affiliated secondary healthcare centre in Liverpool, UK, during Europe's first coronavirus wave (April-June 2020). The survey found that care was rated highly, including among people of Black Asian and Minority Ethnic (BAME) backgrounds. However, sleep-quality and communication about medications and discharge-planning were identified as areas for improvement. Methods: To improve care for people with COVID-19 admitted to our centre, we designed an educational package for healthcare professionals working on COVID-19 wards. The package, implemented in August 2020, included healthcare worker training sessions on providing holistic care and placement of \"Practice Pointers\" posters. Patient satisfaction was re-evaluated during the second/third COVID-19 waves in Liverpool (September 2020 - February 2021). Results: Across waves, most (95%) respondents reported that they would recommend our hospital to friends and/or family and rated overall care highly. Comparison of the responses of second/third-wave respondents (n=101) with first-wave respondents (n=94) suggested improved patient satisfaction across most care domains but especially those related to having worries and fears addressed and being consulted about medications and their side-effects. Conclusions: People admitted with COVID-19 to our centre in Liverpool, including those from BAME backgrounds, rated the care they received highly. A simple education package improved the feedback on care received by respondents between the first and second/third waves. These UK-first findings are informing regional strategies to improve person-centred care of hospitalised people with COVID-19.", "doi": "10.12688/wellcomeopenres.17163.2", "pmid": "35118199", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8787571.2"}], "notes": [], "created": "2022-02-06T16:46:17.605Z", "modified": "2022-02-08T15:17:21.605Z"}, {"entity": "publication", "iuid": "4b540bc2f54746448d5bdbf914ca7561", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b540bc2f54746448d5bdbf914ca7561.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b540bc2f54746448d5bdbf914ca7561"}}, "title": "The importance of accessory protein variants in the pathogenicity of SARS-CoV-2.", "authors": [{"family": "Hassan", "given": "Sk Sarif", "initials": "SS"}, {"family": "Choudhury", "given": "Pabitra Pal", "initials": "PP"}, {"family": "Dayhoff", "given": "Guy W", "initials": "GW"}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA"}, {"family": "Uhal", "given": "Bruce D", "initials": "BD"}, {"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Pizzol", "given": "Damiano", "initials": "D"}, {"family": "Adadi", "given": "Parise", "initials": "P"}, {"family": "Lal", "given": "Amos", "initials": "A"}, {"family": "Soares", "given": "Antonio", "initials": "A"}, {"family": "Mohamed Abd El-Aziz", "given": "Tarek", "initials": "T"}, {"family": "Brufsky", "given": "Adam M", "initials": "AM"}, {"family": "Azad", "given": "Gajendra Kumar", "initials": "GK"}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Baetas-da-Cruz", "given": "Wagner", "initials": "W"}, {"family": "Takayama", "given": "Kazuo", "initials": "K"}, {"family": "Serrano-Aroca", "given": "\u00c3ngel", "initials": "\u00c3"}, {"family": "Chauhan", "given": "Gaurav", "initials": "G"}, {"family": "Palu", "given": "Giorgio", "initials": "G"}, {"family": "Mishra", "given": "Yogendra Kumar", "initials": "YK"}, {"family": "Barh", "given": "Debmalya", "initials": "D"}, {"family": "Santana Silva", "given": "Raner Jo\u015be", "initials": "RJ"}, {"family": "Andrade", "given": "Bruno Silva", "initials": "BS"}, {"family": "Azevedo", "given": "Vasco", "initials": "V"}, {"family": "G\u00f3es-Neto", "given": "Arist\u00f3teles", "initials": "A"}, {"family": "Bazan", "given": "Nicolas G", "initials": "NG"}, {"family": "Redwan", "given": "Elrashdy M", "initials": "EM"}, {"family": "Tambuwala", "given": "Murtaza", "initials": "M"}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN"}], "type": "journal article", "published": "2022-01-24", "journal": {"title": "Arch Biochem Biophys", "issn": "1096-0384", "volume": "717", "pages": "109124", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 possess putative functions to manipulate host immune mechanisms. These involve interferons, which appear as a consensus function, immune signaling receptor NLRP3 (NLR family pyrin domain-containing 3) inflammasome, and inflammatory cytokines such as interleukin 1\u03b2 (IL-1\u03b2) and are critical in COVID-19 pathology. Outspread variations of each of the six accessory proteins were observed across six continents of all complete SARS-CoV-2 proteomes based on the data reported before November 2020. A decreasing order of percentage of unique variations in the accessory proteins was determined as ORF3a > ORF8 > ORF7a > ORF6 > ORF10 > ORF7b across all continents. The highest and lowest unique variations of ORF3a were observed in South America and Oceania, respectively. These findings suggest that the wide variations in accessory proteins seem to affect the pathogenicity of SARS-CoV-2.", "doi": "10.1016/j.abb.2022.109124", "pmid": "35085577", "labels": {"Category: Health": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0003-9861(22)00009-1"}, {"db": "pmc", "key": "PMC8785432"}], "notes": [], "created": "2022-01-31T11:45:10.498Z", "modified": "2022-01-31T11:45:10.533Z"}, {"entity": "publication", "iuid": "5f5d5f35bd3b4786b8079a511e0db6fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f5d5f35bd3b4786b8079a511e0db6fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f5d5f35bd3b4786b8079a511e0db6fd"}}, "title": "Large gaps in the quality of healthcare experienced by Swedish mothers during the COVID-19 pandemic: A cross-sectional study based on WHO standards.", "authors": [{"family": "Zaigham", "given": "Mehreen", "initials": "M"}, {"family": "Linden", "given": "Karolina", "initials": "K"}, {"family": "Sengpiel", "given": "Verena", "initials": "V"}, {"family": "Mariani", "given": "Ilaria", "initials": "I"}, {"family": "Valente", "given": "Emanuelle Pessa", "initials": "EP"}, {"family": "Covi", "given": "Benedetta", "initials": "B"}, {"family": "Lazzerini", "given": "Marzia", "initials": "M"}, {"family": "Elden", "given": "Helen", "initials": "H"}, {"family": "IMAgiNE EURO Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-01-24", "journal": {"title": "Women Birth", "issn": "1878-1799", "issn-l": null}, "abstract": "Existing healthcare systems have been put under immense pressure during the COVID-19 pandemic. Disruptions in essential maternal and newborn services have come from even high-income countries within the World Health Organization (WHO) European Region.\n\nTo describe the quality of care during pregnancy and childbirth, as reported by the women themselves, during the COVID-19 pandemic in Sweden, using the WHO 'Standards for improving quality of maternal and newborn care in health facilities'.\n\nUsing an anonymous, online questionnaire, women \u226518 years were invited to participate if they had given birth in Sweden from March 1, 2020 to June 30, 2021. The quality of maternal and newborn care was measured using 40 questions across four domains: provision of care, experience of care, availability of human/physical resources, and organisational changes due to COVID-19.\n\nOf the 5003 women included, n = 4528 experienced labour. Of these, 46.7% perceived a poorer quality of maternal and newborn care due to the COVID-19. Fundal pressure was applied in 22.2% of instrumental vaginal births, 36.8% received inadequate breastfeeding support and 6.9% reported some form of abuse. Findings were worse in women undergoing prelabour Caesarean section (CS) (n = 475). Multivariate analysis showed significant associations of the quality of maternal and newborn care to year of birth (P < 0.001), parity (P < 0.001), no pharmacological pain relief (P < 0.001), prelabour CS (P < 0.001), emergency CS (P < 0.001) and overall satisfaction (P < 0.001).\n\nConsiderable gaps over many key quality measures and deviations from women-centred care were noted. Findings were worse in women with prelabour CS. Actions to promote high-quality, evidence-based and respectful care during childbirth for all mothers are urgently needed.", "doi": "10.1016/j.wombi.2022.01.007", "pmid": "35123922", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1871-5192(22)00010-5"}], "notes": [], "created": "2022-02-08T15:16:44.040Z", "modified": "2022-02-08T15:16:44.074Z"}, {"entity": "publication", "iuid": "6ca32244d0bc40a1b1fe81f99ab27022", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ca32244d0bc40a1b1fe81f99ab27022.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ca32244d0bc40a1b1fe81f99ab27022"}}, "title": "Job satisfaction and challenges of working from home during the COVID-19 pandemic: A study in a Swedish academic setting.", "authors": [{"family": "Zandi", "given": "Saeid", "initials": "S"}, {"family": "Ahmadi", "given": "Fereshteh", "initials": "F"}, {"family": "Cetrez", "given": "\u00d6nver Andreas", "initials": "\u00d6A"}, {"family": "Akhavan", "given": "Sharareh", "initials": "S"}], "type": "journal article", "published": "2022-01-24", "journal": {"title": "Work", "issn": "1875-9270", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic changed the academic world in various ways, and most universities are still closed and continue operating via teleworking.\r\n\r\nThis study is intended to investigate how university faculty/staff and students in Sweden have coped with the lockdown and working/studying from home during the pandemic.\r\n\r\nA survey was conducted among 277 women and men working and studying at different universities in Sweden.\r\n\r\nThe results indicate that most (61%) respondents were very or somewhat satisfied with the current work-from-home arrangement. Additionally, they indicate that, overall, almost 30% were working more than usual due to the pandemic and teleworking. The coping methods having the highest impact on overall job satisfaction were: \"thinking about what I can do rather than what I can't do\"; \"being able to access medical resources and medical services if I need to seek help\"; and \"having trust in state or health authorities in my country.\"\r\n\r\nThe study reveals that Sweden can serve as a good example of how university faculty/staff and students can address the occupational challenges caused by a health pandemic and possible subsequent quarantines.", "doi": "10.3233/WOR-210442", "pmid": "35095001", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "WOR210442"}], "notes": [], "created": "2022-02-06T17:03:51.861Z", "modified": "2022-11-22T05:40:30.241Z"}, {"entity": "publication", "iuid": "a72928556fb247c2bef359ecfeea0219", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a72928556fb247c2bef359ecfeea0219.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a72928556fb247c2bef359ecfeea0219"}}, "title": "Effects of the Early Phase of COVID-19 on the Autistic Community in Sweden: A Qualitative Multi-Informant Study Linking to ICF.", "authors": [{"family": "Fridell", "given": "Anna", "initials": "A"}, {"family": "Norrman", "given": "Hjalmar Nobel", "initials": "HN"}, {"family": "Girke", "given": "Linda", "initials": "L"}, {"family": "B\u00f6lte", "given": "Sven", "initials": "S"}], "type": "journal article", "published": "2022-01-24", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "3", "issn-l": null}, "abstract": "While the COVID-19 pandemic is ongoing, early outcome studies indicate severe and pervasive global effects of the pandemic and associated measures to prevent the spread of the virus. General population studies, as well as insight into the outcomes for particular groups, will be necessary in order to mitigate potentially long-term effects as well as to prepare for future epidemics or pandemics. The pandemic conditions have been marked by rapid and abrupt changes and unpredictability which are circumstances that leave the autistic population particularly vulnerable to adverse outcomes following the distinctive features of the diagnosis. Studies are only beginning to delineate the outcomes of the global autism community and the present study adds to these findings by providing a local, multi-perspective, qualitative analysis of the lived experiences of the Swedish autism community. In this study, autistic youth and adults, caregivers of autistic individuals, as well as representatives of Swedish interest organizations were interviewed. Thematic analysis was performed on the population as a whole and patterns of results were formalized according to the International Classification of Function, Disability and Health (ICF-CY). Participants report wide-ranging adverse outcomes of the pandemic relating to mental health and access to support, participation in daily activities and socialization, education, and work as well as parental resources. However, participants also report positive outcomes relating to a reduction in specific social and everyday demands, and normalization of lived experiences. Additionally, interviews outlined some strategies used to cope during pandemic conditions. Implications of these findings are discussed.", "doi": "10.3390/ijerph19031268", "pmid": "35162290", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph19031268"}], "notes": [], "created": "2022-02-17T06:09:37.469Z", "modified": "2022-02-17T06:09:37.480Z"}, {"entity": "publication", "iuid": "232f63dad3c74e8d88722bbe6132904e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/232f63dad3c74e8d88722bbe6132904e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/232f63dad3c74e8d88722bbe6132904e"}}, "title": "A Model Predicting Mortality of Hospitalized Covid-19 Patients Four Days After Admission: Development, Internal and Temporal-External Validation.", "authors": [{"family": "Heber", "given": "Stefan", "initials": "S"}, {"family": "Pereyra", "given": "David", "initials": "D"}, {"family": "Schrottmaier", "given": "Waltraud C", "initials": "WC"}, {"family": "Kammerer", "given": "Kerstin", "initials": "K"}, {"family": "Santol", "given": "Jonas", "initials": "J"}, {"family": "Rumpf", "given": "Benedikt", "initials": "B"}, {"family": "Pawelka", "given": "Erich", "initials": "E"}, {"family": "Hanna", "given": "Markus", "initials": "M"}, {"family": "Scholz", "given": "Alexander", "initials": "A"}, {"family": "Liu", "given": "Markus", "initials": "M"}, {"family": "Hell", "given": "Agnes", "initials": "A"}, {"family": "Heiplik", "given": "Klara", "initials": "K"}, {"family": "Lickefett", "given": "Benno", "initials": "B"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Traugott", "given": "Marianna T", "initials": "MT"}, {"family": "Neub\u00f6ck", "given": "Matthias J", "initials": "MJ"}, {"family": "Sch\u00f6rgenhofer", "given": "Christian", "initials": "C"}, {"family": "Seitz", "given": "Tamara", "initials": "T"}, {"family": "Firbas", "given": "Christa", "initials": "C"}, {"family": "Karolyi", "given": "Mario", "initials": "M"}, {"family": "Weiss", "given": "G\u00fcnter", "initials": "G"}, {"family": "Jilma", "given": "Bernd", "initials": "B"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Bellmann-Weiler", "given": "Rosa", "initials": "R"}, {"family": "Salzer", "given": "Helmut J F", "initials": "HJF"}, {"family": "Szepannek", "given": "Gero", "initials": "G"}, {"family": "Fischer", "given": "Michael J M", "initials": "MJM"}, {"family": "Zoufaly", "given": "Alexander", "initials": "A"}, {"family": "Gleiss", "given": "Andreas", "initials": "A"}, {"family": "Assinger", "given": "Alice", "initials": "A"}], "type": "journal article", "published": "2022-01-24", "journal": {"title": "Front Cell Infect Microbiol", "issn": "2235-2988", "volume": "11", "pages": "795026", "issn-l": null}, "abstract": "To develop and validate a prognostic model for in-hospital mortality after four days based on age, fever at admission and five haematological parameters routinely measured in hospitalized Covid-19 patients during the first four days after admission.\n\nHaematological parameters measured during the first 4 days after admission were subjected to a linear mixed model to obtain patient-specific intercepts and slopes for each parameter. A prediction model was built using logistic regression with variable selection and shrinkage factor estimation supported by bootstrapping. Model development was based on 481 survivors and 97 non-survivors, hospitalized before the occurrence of mutations. Internal validation was done by 10-fold cross-validation. The model was temporally-externally validated in 299 survivors and 42 non-survivors hospitalized when the Alpha variant (B.1.1.7) was prevalent.\n\nThe final model included age, fever on admission as well as the slope or intercept of lactate dehydrogenase, platelet count, C-reactive protein, and creatinine. Tenfold cross validation resulted in a mean area under the receiver operating characteristic curve (AUROC) of 0.92, a mean calibration slope of 1.0023 and a Brier score of 0.076. At temporal-external validation, application of the previously developed model showed an AUROC of 0.88, a calibration slope of 0.95 and a Brier score of 0.073. Regarding the relative importance of the variables, the (apparent) variation in mortality explained by the six variables deduced from the haematological parameters measured during the first four days is higher (explained variation 0.295) than that of age (0.210).\n\nThe presented model requires only variables routinely acquired in hospitals, which allows immediate and wide-spread use as a decision support for earlier discharge of low-risk patients to reduce the burden on the health care system.\n\nAustrian Coronavirus Adaptive Clinical Trial (ACOVACT); ClinicalTrials.gov, identifier NCT04351724.", "doi": "10.3389/fcimb.2021.795026", "pmid": "35141170", "labels": {"Category: Health": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pmc", "key": "PMC8819729"}, {"db": "ClinicalTrials.gov", "key": "NCT04351724"}], "notes": [], "created": "2022-02-11T10:22:45.318Z", "modified": "2022-02-11T10:23:22.712Z"}, {"entity": "publication", "iuid": "9b7b92f7ea4d4787ad56daa4bc4e4930", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b7b92f7ea4d4787ad56daa4bc4e4930.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b7b92f7ea4d4787ad56daa4bc4e4930"}}, "title": "Predictive performance and clinical application of COV50, a urinary proteomic biomarker in early COVID-19 infection: a cohort study", "authors": [{"family": "Staessen", "given": "Jan A", "initials": "JA"}, {"family": "Wendt", "given": "Ralph", "initials": "R"}, {"family": "Yu", "given": "Yu Ling", "initials": "YL"}, {"family": "Thijs", "given": "Lutgarde", "initials": "L"}, {"family": "Siwy", "given": "Justyna", "initials": "J"}, {"family": "Raad", "given": "Julia", "initials": "J"}, {"family": "Metzger", "given": "Jochen", "initials": "J"}, {"family": "Neuhaus", "given": "Barbara", "initials": "B"}, {"family": "Papkalla", "given": "Armin", "initials": "A"}, {"family": "von der Leyen", "given": "Heiko", "initials": "H"}, {"family": "Mebazaa", "given": "Alexandre", "initials": "A"}, {"family": "Dudoignon", "given": "Emmanual", "initials": "E"}, {"family": "Spasovski", "given": "Goce", "initials": "G"}, {"family": "Milenkova", "given": "Mimoza", "initials": "M"}, {"family": "Canevska-Taneska", "given": "Aleksandra", "initials": "A"}, {"family": "Psichogiou", "given": "Mina", "initials": "M"}, {"family": "Rajzer", "given": "Marke W", "initials": "MW"}, {"family": "Fulawka", "given": "Lukasz", "initials": "L"}, {"family": "Dzitkowska-Zabielska", "given": "Magdalena", "initials": "M"}, {"family": "Weiss", "given": "Guenter", "initials": "G"}, {"family": "Feldt", "given": "Torsten", "initials": "T"}, {"family": "Stegemann", "given": "Miriam", "initials": "M"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Zoufaly", "given": "Alexander", "initials": "A"}, {"family": "Schmiedel", "given": "Stefan", "initials": "S"}, {"family": "Seilmaier", "given": "Michael", "initials": "M"}, {"family": "Rumpf", "given": "Benedikt", "initials": "B"}, {"family": "Banasik", "given": "Miroslaw", "initials": "M"}, {"family": "Krajewska", "given": "Magdalena", "initials": "M"}, {"family": "Catanese", "given": "Lorenzo", "initials": "L"}, {"family": "Rupprecht", "given": "Harald", "initials": "H"}, {"family": "Czerwienska", "given": "Beata", "initials": "B"}, {"family": "Peters", "given": "Bjoern", "initials": "B"}, {"family": "Nilsson", "given": "Asa", "initials": "A"}, {"family": "Rothfuss", "given": "Katja", "initials": "K"}, {"family": "Luebbert", "given": "Christoph", "initials": "C"}, {"family": "Mischak", "given": "Harald", "initials": "H"}, {"family": "Beige", "given": "Joachim", "initials": "J"}], "type": "posted-content", "published": "2022-01-23", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.01.20.22269599", "pmid": null, "labels": {"Category: Health": null, "Type: Preprint": null, "Category: Biochemistry": null, "Category: Omicron VoC": null}, "xrefs": [], "notes": [], "created": "2022-01-24T10:43:58.258Z", "modified": "2022-01-26T16:37:04.903Z"}, {"entity": "publication", "iuid": "d9acb2305e904b518161562e376043a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d9acb2305e904b518161562e376043a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d9acb2305e904b518161562e376043a1"}}, "title": "Pilot application of Lecture-Panel-Discussion Model (LPDM) in global collaborative neurosurgical education: a novel training paradigm innovated by the Swedish African Neurosurgery Collaboration.", "authors": [{"family": "Uche", "given": "Enoch Ogbonnaya", "initials": "EO"}, {"family": "Sundblom", "given": "Jimmy", "initials": "J"}, {"family": "Iloabachie", "given": "Izuchukwu", "initials": "I"}, {"family": "Ozoh", "given": "Ignatius I", "initials": "II"}, {"family": "Alalade", "given": "Andrew", "initials": "A"}, {"family": "Revesz", "given": "David", "initials": "D"}, {"family": "Sandvik", "given": "Ulrika", "initials": "U"}, {"family": "Olsson", "given": "Martin", "initials": "M"}, {"family": "Mezue", "given": "Wilfred C", "initials": "WC"}, {"family": "Tisell", "given": "Magnus", "initials": "M"}, {"family": "Ryttlefors", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2022-01-21", "journal": {"title": "Acta Neurochir (Wien)", "issn": "0942-0940", "issn-l": "0001-6268"}, "abstract": "Disruptions in global surgery educational routines by the COVID-19 pandemic have elicited demands for alternative formats for rendering qualitative neurosurgical education. This study presents application of a novel model of online neurosurgical course, the Lecture-Panel-Discussion Model (LPDM).\n\nThis is a cross-sectional survey of participants who attended the Swedish African Neurosurgery Collaboration (SANC)-100A course. Participants evaluated the course through an online self-administered questionnaire using a 5-point Likert scale ranging from very poor-1, poor-2, average (fair)-3, good-4, to excellent-5. SANC-100A comprises a tripod of Lectures, Panel review, and interactive case Discussion. This model (LPDM) was innovated by SANC and applied at the Enugu International Neurosurgery course in February 2021.\n\nThere were 71 attendees, 19 were course faculty, while 52 were participants. Thirty-five attended from Nigeria, 11 from Sweden, 3 from Malawi, 2 from Senegal, and 1 from the UK. Among 44 participants who completed the questionnaire, there were 9 fellows and 35 residents. The overall median course Likert rating was 4.65 \u00b1 0.1. The median overall rating for course events was similar between day 1 (Likert score = 4.45) and day 2 (Likert score = 4.55), U = 55, Z score = 1.10, P = 0.27. The median rating for lectures was 4.50 \u00b1 0.2 and varied from 4.40 on day 1 to 4.55 on day 2. The median rating for panel review was 4.60 \u00b1 0.1 and varied from 4.55 on day 1 to 4.65 on day 2. Interactive case discussions were rated 4.80 on both course days. There was a significant variability in the rating profiles of the course tripod: U = 24.5, P = 0.03. Fifty-one (98%) participants believe LPDM was COVID-19-compliant, while 90% believe the course was beneficial to training and practice.\n\nInitial application of LPDM is rewarded with both high acceptance and high rating among participants.", "doi": "10.1007/s00701-021-05071-z", "pmid": "35059854", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00701-021-05071-z"}], "notes": [], "created": "2022-01-26T10:20:45.277Z", "modified": "2022-01-26T10:20:45.291Z"}, {"entity": "publication", "iuid": "92f14a1b80b249c09fd7efedcc332a40", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/92f14a1b80b249c09fd7efedcc332a40.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/92f14a1b80b249c09fd7efedcc332a40"}}, "title": "Participatory research in times of COVID-19 and beyond: Adjusting your methodological toolkits.", "authors": [{"family": "Sattler", "given": "Claudia", "initials": "C"}, {"family": "Rommel", "given": "Jens", "initials": "J"}, {"family": "Chen", "given": "Cheng", "initials": "C"}, {"family": "Garc\u00eda-Llorente", "given": "Marina", "initials": "M"}, {"family": "Guti\u00e9rrez-Brice\u00f1o", "given": "In\u00e9s", "initials": "I"}, {"family": "Prager", "given": "Katrin", "initials": "K"}, {"family": "Reyes", "given": "Maria F", "initials": "MF"}, {"family": "Schr\u00f6ter", "given": "Barbara", "initials": "B"}, {"family": "Schulze", "given": "Christoph", "initials": "C"}, {"family": "van Bussel", "given": "Lenny G J", "initials": "LGJ"}, {"family": "Loft", "given": "Lasse", "initials": "L"}, {"family": "Matzdorf", "given": "Bettina", "initials": "B"}, {"family": "Kelemen", "given": "Eszter", "initials": "E"}], "type": "journal article", "published": "2022-01-21", "journal": {"title": "One Earth", "issn": "2590-3322", "volume": "5", "issue": "1", "pages": "62-73", "issn-l": null}, "abstract": "Solving grand environmental societal challenges calls for transdisciplinary and participatory methods in social-ecological research. These methods enable co-designing the research, co-producing the results, and co-creating the impacts together with concerned stakeholders. COVID-19 has had serious impacts on the choice of research methods, but reflections on recent experiences of \"moving online\" are still rare. In this perspective, we focus on the challenge of adjusting different participatory methods to online formats used in five transdisciplinary social-ecological research projects. The key added value of our research is the lessons learned from a comparison of the pros and cons of adjusting a broader set of methods to online formats. We conclude that combining the adjusted online approaches with well-established face-to-face formats into more inclusive hybrid approaches can enrich and diversify the pool of available methods for postpandemic research. Furthermore, a more diverse group of participants can be engaged in the research process.", "doi": "10.1016/j.oneear.2021.12.006", "pmid": "35098107", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2590-3322(21)00724-7"}, {"db": "pmc", "key": "PMC8779601"}], "notes": [], "created": "2022-02-06T16:55:58.322Z", "modified": "2022-02-06T16:55:58.360Z"}, {"entity": "publication", "iuid": "8e0d6a9eb1764446be31099616f108c4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e0d6a9eb1764446be31099616f108c4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e0d6a9eb1764446be31099616f108c4"}}, "title": "T cell immune responses following vaccination with mRNA BNT162b2 against SARS-CoV-2 in patients with chronic lymphocytic leukemia: results from a prospective open-label clinical trial.", "authors": [{"family": "Blixt", "given": "Lisa", "initials": "L"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Lundin", "given": "Jeanette", "initials": "J"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Lange", "given": "Joshua", "initials": "J"}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2022-01-20", "journal": {"title": "Haematologica", "issn": "1592-8721", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Not available.", "doi": "10.3324/haematol.2021.280300", "pmid": "35045694", "labels": {"Category: Health": null, "Research Area: Vaccine": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null, "Category: Biochemistry": null, "Funder: VR": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-27T07:06:13.587Z", "modified": "2022-02-08T19:16:56.522Z"}, {"entity": "publication", "iuid": "3d77564dec9844b2be0cb5f748485ca0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3d77564dec9844b2be0cb5f748485ca0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3d77564dec9844b2be0cb5f748485ca0"}}, "title": "SARS-CoV-2 infections in children: Understanding diverse outcomes.", "authors": [{"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}], "type": "journal article", "published": "2022-01-20", "journal": {"title": "Immunity", "issn": "1074-7613", "issn-l": null}, "abstract": "SARS-CoV-2 infections mostly lead to mild or even asymptomatic infections in children, but the reasons for this are not fully understood. More efficient local tissue responses, better thymic function, and cross-reactive immunity have all been proposed to explain this. In rare cases of children and young people, but very rarely in adults, post-infectious hyperinflammatory syndromes can develop and be serious. Here, I will discuss our current understanding of SARS-CoV-2 infections in children and hypothesize that a life history and energy allocation perspective might offer an additional explanation to mild infections, viral dynamics, and the higher incidence of rare multisystem inflammatory syndromes in children and young people.", "doi": "10.1016/j.immuni.2022.01.014", "pmid": "35093190", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1074-7613(22)00043-7"}, {"db": "pmc", "key": "PMC8769938"}], "notes": [], "created": "2022-01-24T09:19:30.621Z", "modified": "2022-02-06T17:06:42.917Z"}, {"entity": "publication", "iuid": "e83da5ea90ee4b06bc174c3608e8d23b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e83da5ea90ee4b06bc174c3608e8d23b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e83da5ea90ee4b06bc174c3608e8d23b"}}, "title": "Novel universal SARS-CoV DNA vaccine inducing neutralizing antibodies to huCoV-19/WH01, Beta, Delta and Omicron variants and T cells to Bat-CoV", "authors": [{"family": "Appelberg", "given": "K Sofia", "initials": "KS"}, {"family": "Ahlen", "given": "Gustaf", "initials": "G"}, {"family": "Nikoyan", "given": "Negin", "initials": "N"}, {"family": "Yan", "given": "Jingy", "initials": "J"}, {"family": "Weber", "given": "Sofie", "initials": "S"}, {"family": "Larsson", "given": "Olivia", "initials": "O"}, {"family": "H\u00f6glund", "given": "Urban", "initials": "U"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Weber", "given": "Friedemann", "initials": "F", "orcid": "0000-0001-9737-337X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cfac6ca689c5467396ede57ba57092da.json"}}, {"family": "Perlhamre", "given": "Emma", "initials": "E"}, {"family": "Apro", "given": "Johanna", "initials": "J"}, {"family": "Gidlund", "given": "Eva Karin", "initials": "EK"}, {"family": "Tuvesson", "given": "Ola", "initials": "O"}, {"family": "Cadossi", "given": "Matteo", "initials": "M"}, {"family": "Salati", "given": "SImona", "initials": "S"}, {"family": "Tegel", "given": "Hanna", "initials": "H"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Frelin", "given": "Lars", "initials": "L", "orcid": "0000-0001-7452-1667", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd26ddedec244820a9a1e19f76cc5cf8.json"}}, {"family": "mirazimi", "given": "ali", "initials": "a"}, {"family": "Sallberg", "given": "Matti", "initials": "M", "orcid": "0000-0002-8858-5132", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ef589af054b4f94a635ce4021d19ed6.json"}}], "type": "posted-content", "published": "2022-01-20", "journal": {"title": "Research Square", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.21203/rs.3.rs-1276351/v1", "pmid": null, "labels": {"Category: Health": null, "Category: Omicron VoC": null, "Type: Preprint": null, "Category: Drug Discovery": null, "Category: Vaccines": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2022-01-24T10:55:49.379Z", "modified": "2022-01-26T16:38:06.958Z"}, {"entity": "publication", "iuid": "f302bc3bc1c24074ab1bb8f78b8b243f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f302bc3bc1c24074ab1bb8f78b8b243f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f302bc3bc1c24074ab1bb8f78b8b243f"}}, "title": "High prevalence of olfactory disorders 18 months after contracting COVID-19", "authors": [{"family": "Tognetti", "given": "Arnaud", "initials": "A"}, {"family": "Thunell", "given": "Evelina", "initials": "E"}, {"family": "Olsson", "given": "Mats J", "initials": "MJ"}, {"family": "Greilert", "given": "Nina", "initials": "N"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Lundstr\u00f6m", "given": "Johan N", "initials": "JN", "orcid": "0000-0002-3529-8981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a92f50aea024a1fbf0cfda979efef11.json"}}], "type": "posted-content", "published": "2022-01-20", "journal": {"title": "MedRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.01.20.22269490", "pmid": null, "labels": {"Category: Health": null, "Type: Preprint": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [], "notes": [], "created": "2022-01-24T10:45:16.438Z", "modified": "2022-02-09T10:21:37.412Z"}, {"entity": "publication", "iuid": "2d906d15a3034d36b0d9c471c35ad573", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d906d15a3034d36b0d9c471c35ad573.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d906d15a3034d36b0d9c471c35ad573"}}, "title": "A Workflow of Integrated Resources to Catalyze Network Pharmacology Driven COVID-19 Research.", "authors": [{"family": "Zahor\u00e1nszky-K\u0151halmi", "given": "Gergely", "initials": "G", "orcid": "0000-0002-2534-8770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70698b6bf86944b29f19bbf9c2d86ee0.json"}}, {"family": "Siramshetty", "given": "Vishal B", "initials": "VB"}, {"family": "Kumar", "given": "Praveen", "initials": "P"}, {"family": "Gurumurthy", "given": "Manideep", "initials": "M"}, {"family": "Grillo", "given": "Busola", "initials": "B"}, {"family": "Mathew", "given": "Biju", "initials": "B"}, {"family": "Metaxatos", "given": "Dimitrios", "initials": "D"}, {"family": "Backus", "given": "Mark", "initials": "M"}, {"family": "Mierzwa", "given": "Tim", "initials": "T"}, {"family": "Simon", "given": "Reid", "initials": "R"}, {"family": "Grishagin", "given": "Ivan", "initials": "I"}, {"family": "Brovold", "given": "Laura", "initials": "L"}, {"family": "Math\u00e9", "given": "Ewy A", "initials": "EA", "orcid": "0000-0003-4491-8107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/526c8532f9b844e1b26ff8f4b131aab2.json"}}, {"family": "Hall", "given": "Matthew D", "initials": "MD", "orcid": "0000-0002-5073-442X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5b2d73bea15483db987059eccaf46ad.json"}}, {"family": "Michael", "given": "Samuel G", "initials": "SG"}, {"family": "Godfrey", "given": "Alexander G", "initials": "AG"}, {"family": "Mestres", "given": "Jordi", "initials": "J", "orcid": "0000-0002-5202-4501", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ca82613f43dc465b847d30b08de7c560.json"}}, {"family": "Jensen", "given": "Lars J", "initials": "LJ", "orcid": "0000-0001-7885-715X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0da9399aac04409eb3b87ac9f00728a8.json"}}, {"family": "Oprea", "given": "Tudor I", "initials": "TI", "orcid": "0000-0002-6195-6976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c480e6e946bd4c43ac430fd0309df71e.json"}}], "type": "journal article", "published": "2022-01-20", "journal": {"title": "J Chem Inf Model", "issn": "1549-960X", "issn-l": null}, "abstract": "In the event of an outbreak due to an emerging pathogen, time is of the essence to contain or to mitigate the spread of the disease. Drug repositioning is one of the strategies that has the potential to deliver therapeutics relatively quickly. The SARS-CoV-2 pandemic has shown that integrating critical data resources to drive drug-repositioning studies, involving host-host, host-pathogen, and drug-target interactions, remains a time-consuming effort that translates to a delay in the development and delivery of a life-saving therapy. Here, we describe a workflow we designed for a semiautomated integration of rapidly emerging data sets that can be generally adopted in a broad network pharmacology research setting. The workflow was used to construct a COVID-19 focused multimodal network that integrates 487 host-pathogen, 63 278 host-host protein, and 1221 drug-target interactions. The resultant Neo4j graph database named \"Neo4COVID19\" is made publicly accessible via a web interface and via API calls based on the Bolt protocol. Details for accessing the database are provided on a landing page (https://neo4covid19.ncats.io/). We believe that our Neo4COVID19 database will be a valuable asset to the research community and will catalyze the discovery of therapeutics to fight COVID-19.", "doi": "10.1021/acs.jcim.1c00431", "pmid": "35057621", "labels": {"Category: Health": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-26T10:21:09.747Z", "modified": "2022-01-26T10:21:09.983Z"}, {"entity": "publication", "iuid": "8fb2b02dc0744b3997713ef4b0ec145e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8fb2b02dc0744b3997713ef4b0ec145e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8fb2b02dc0744b3997713ef4b0ec145e"}}, "title": "A Method for Estimating the Number of Infections From the Reported Number of Deaths.", "authors": [{"family": "Br\u00e4nnstr\u00f6m", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Sj\u00f6din", "given": "Henrik", "initials": "H"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}], "type": "journal article", "published": "2022-01-20", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "648545", "issn-l": "2296-2565"}, "abstract": "At the outset of an epidemic, available case data typically underestimate the total number of infections due to insufficient testing, potentially hampering public responses. Here, we present a method for statistically estimating the true number of cases with confidence intervals from the reported number of deaths and estimates of the infection fatality ratio; assuming that the time from infection to death follows a known distribution. While the method is applicable to any epidemic with a significant mortality rate, we exemplify the method by applying it to COVID-19. Our findings indicate that the number of unreported COVID-19 infections in March 2020 was likely to be at least one order of magnitude higher than the reported cases, with the degree of underestimation among the countries considered being particularly high in the United Kingdom.", "doi": "10.3389/fpubh.2021.648545", "pmid": "35111706", "labels": {"Category: Other": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8802715"}], "notes": [], "created": "2022-02-06T16:48:45.724Z", "modified": "2022-02-06T16:48:45.737Z"}, {"entity": "publication", "iuid": "f1d335e823fa47ffaf043b0138ee7479", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1d335e823fa47ffaf043b0138ee7479.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1d335e823fa47ffaf043b0138ee7479"}}, "title": "Overexpression of the SARS-CoV-2 receptor angiotensin converting enzyme 2 in cardiomyocytes of failing hearts.", "authors": [{"family": "Vukusic", "given": "Kristina", "initials": "K"}, {"family": "Thorsell", "given": "Annika", "initials": "A"}, {"family": "Muslimovic", "given": "Aida", "initials": "A"}, {"family": "Jonsson", "given": "Marianne", "initials": "M"}, {"family": "Dellgren", "given": "G\u00f6ran", "initials": "G"}, {"family": "Lindahl", "given": "Anders", "initials": "A"}, {"family": "Sandstedt", "given": "Joakim", "initials": "J"}, {"family": "Hammarsten", "given": "Ola", "initials": "O"}], "type": "journal article", "published": "2022-01-19", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "965", "issn-l": "2045-2322"}, "abstract": "Hospitalized patients who die from Covid-19 often have pre-existing heart disease. The SARS-CoV-2 virus is dependent on the ACE2 receptor to be able to infect cells. It is possible that the strong link between cardiovascular comorbidities and a poor outcome following a SARS-CoV-2 infection is sometimes due to viral myocarditis. The aim was to examine the expression of ACE2 in normal hearts and hearts from patients with terminal heart failure. The ACE2 expression was measured by global quantitative proteomics and RT-qPCR in left ventricular (LV) tissue from explanted hearts. Immunohistochemistry was used to examine ACE2 expression in cardiomyocytes, fibroblasts and endothelial cells. In total, tissue from 14 organ donors and 11 patients with terminal heart failure were included. ACE2 expression was 2.6 times higher in 4 hearts from patients with terminal heart failure compared with 6 healthy donor hearts. The results were confirmed by immunohistochemistry where more than half of cardiomyocytes or fibroblasts showed expression of ACE2 in hearts from patients with terminal heart failure. In healthy donor hearts ACE2 was not expressed or found in few fibroblasts. A small subpopulation of endothelial cells expressed ACE2 in both groups. Upregulated ACE2 expression in cardiomyocytes may increase the risk of SARS-CoV-2 myocarditis in patients with heart failure.", "doi": "10.1038/s41598-022-04956-y", "pmid": "35046458", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-04956-y"}, {"db": "pmc", "key": "PMC8770525"}], "notes": [], "created": "2022-01-27T07:04:03.703Z", "modified": "2022-01-27T07:04:03.717Z"}, {"entity": "publication", "iuid": "6635e3f8535740968c9fdc520dc224e6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6635e3f8535740968c9fdc520dc224e6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6635e3f8535740968c9fdc520dc224e6"}}, "title": "Loss of Y in leukocytes as a risk factor for critical COVID-19 in men", "authors": [{"family": "Bruhn-Olszewska", "given": "Bo\u017cena", "initials": "B", "orcid": "0000-0003-2141-0247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dedfa26bf2d048b7b8e45b5e057c92a1.json"}}, {"family": "Davies", "given": "Hanna", "initials": "H", "orcid": "0000-0002-6289-3815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e47c749e23324a6dbbe27c4fc980d44d.json"}}, {"family": "Sarkisyan", "given": "Daniil", "initials": "D", "orcid": "0000-0002-2451-4386", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e35e9da7e5074089a9c12af2f8fac728.json"}}, {"family": "Juhas", "given": "Ulana", "initials": "U", "orcid": "0000-0001-8393-5845", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2eb6588951114e6ea94c2044e057baa8.json"}}, {"family": "Rychlicka-Buniowska", "given": "Edyta", "initials": "E", "orcid": "0000-0001-8050-2489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/408d42c146da46dcb096476de68870ce.json"}}, {"family": "W\u00f3jcik", "given": "Magdalena", "initials": "M"}, {"family": "Horbacz", "given": "Monika", "initials": "M", "orcid": "0000-0003-1644-2957", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cd269c5ae484ab5bdf9cc96b4e5803d.json"}}, {"family": "J\u0105kalski", "given": "Marcin", "initials": "M", "orcid": "0000-0002-5481-9148", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65510c2de4984c5ab5c221af3c00258e.json"}}, {"family": "Olszewski", "given": "Pawe\u0142", "initials": "P", "orcid": "0000-0002-2788-5254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7546c2273a0b41318e03b0b6b8386644.json"}}, {"family": "Westholm", "given": "Jakub O", "initials": "JO", "orcid": "0000-0002-6849-6220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8f7f8b02a9748f09626d373504ed84d.json"}}, {"family": "Smialowska", "given": "Agata", "initials": "A"}, {"family": "Wierzba", "given": "Karol", "initials": "K", "orcid": "0000-0003-1257-4047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/acaa0094bb054d10bf5b9037e5e05468.json"}}, {"family": "Naluai", "given": "\u00c5sa Torinsson", "initials": "\u00c5T", "orcid": "0000-0002-0504-6492", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ec904138d45463ea133b3ea7a062e08.json"}}, {"family": "Jern", "given": "Niklas", "initials": "N"}, {"family": "Andersson", "given": "Lars Magnus", "initials": "LM", "orcid": "0000-0002-9203-5969", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9cc0ebc0e6d433fbec6ca555a329ca3.json"}}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD", "orcid": "0000-0002-7075-1059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4c50079915c44d39c996741c6156bfa.json"}}, {"family": "Filipowicz", "given": "Natalia", "initials": "N", "orcid": "0000-0002-9673-2649", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf3f9e58fdfe466e8e4a224c0b451878.json"}}, {"family": "Janson", "given": "Eva Tiensuu", "initials": "ET", "orcid": "0000-0002-1649-4880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce68e15ca80a4813b20e055ea8c408c0.json"}}, {"family": "Rubertsson", "given": "Sten", "initials": "S"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Dumanski", "given": "Jan P", "initials": "JP", "orcid": "0000-0002-1489-1452", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f429f169193e41c78e76c206e9540cd8.json"}}], "type": "posted-content", "published": "2022-01-19", "journal": {"title": "MedRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.01.19.22269521", "pmid": null, "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Type: Preprint": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Funder: VR": null, "Research Area: Call 2": null}, "xrefs": [], "notes": [], "created": "2022-01-24T10:47:41.713Z", "modified": "2022-11-22T05:53:59.725Z"}, {"entity": "publication", "iuid": "1048b06d2e1146f2a460ad4b0a260684", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1048b06d2e1146f2a460ad4b0a260684.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1048b06d2e1146f2a460ad4b0a260684"}}, "title": "Assessment of biosafety implementation in clinical diagnostic laboratories in pakistan related to the COVID-19 pandemic.", "authors": [{"family": "Sarwar", "given": "Samreen", "initials": "S"}, {"family": "Shahzad", "given": "Faheem", "initials": "F"}, {"family": "Vajeeha", "given": "Ayesha", "initials": "A"}, {"family": "Munir", "given": "Rimsha", "initials": "R"}, {"family": "Yaqoob", "given": "Amina", "initials": "A"}, {"family": "Naeem", "given": "Aniqa", "initials": "A"}, {"family": "Sattar", "given": "Mamoona", "initials": "M"}, {"family": "Gull", "given": "Sheereen", "initials": "S"}], "type": "journal article", "published": "2022-01-19", "journal": {"title": "J Biosaf Biosecur", "issn": "2588-9338", "issn-l": null}, "abstract": "Laboratory diagnostic capacity is crucial for an optimal national response to a public health emergency such as the COVID-19 pandemic. Preventing laboratory-acquired infections and the loss of critical human resources, especially during a public health emergency, requires laboratories to have a good biorisk management system in place. In this study, we aimed to evaluate laboratory biosafety and biosecurity in Pakistan during the COVID-19 pandemic. In this cross-sectional study, a self-rated anonymous questionnaire was distributed to laboratory professionals (LPs) working in clinical diagnostic laboratories, including laboratories performing polymerase chain reaction (PCR)-based COVID-19 diagnostic testing in Punjab, Sindh, Khyber Pakhtunkhwa, and Gilgit-Baltistan provinces as well as Islamabad during March 2020 to April 2020. The questionnaire assessed knowledge and perceptions of LPs, resource availability, and commitment by top management in these laboratories. In total, 58.6% of LPs performing COVID-19 testing reported that their laboratory did not conduct a biorisk assessment before starting COVID-19 testing in their facility. Only 31% of LPs were aware that COVID-19 testing could be performed at a biosafety level 2 laboratory, as per the World Health Organization interim biosafety guidelines. A sufficiently high percentage of LPs did not feel confident in their ability to handle COVID-19 samples (32.8%), spills (43.1%), or other accidents (32.8%). These findings demonstrate the need for effective biosafety program implementation, proper training, and establishing competency assessment methods. These findings also suggested that identifying and addressing gaps in existing biorisk management systems through sustainable interventions and preparing LPs for surge capacity is crucial to better address public health emergencies.", "doi": "10.1016/j.jobb.2022.01.001", "pmid": "35072000", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2588-9338(22)00001-2"}, {"db": "pmc", "key": "PMC8768056"}], "notes": [], "created": "2022-01-26T10:16:06.535Z", "modified": "2022-01-26T10:16:06.564Z"}, {"entity": "publication", "iuid": "ac9452c851ea4129b2d9be95df87dfe5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac9452c851ea4129b2d9be95df87dfe5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac9452c851ea4129b2d9be95df87dfe5"}}, "title": "The global pandemic and changes in women's reproductive health: an observational study.", "authors": [{"family": "Haile", "given": "Liya", "initials": "L", "orcid": "0000-0001-9170-4879", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a55e8c5467f64375a0bb34018bcb3253.json"}}, {"family": "van de Roemer", "given": "Niels", "initials": "N"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K", "orcid": "0000-0001-6516-1444", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be16fea6bd1042048b8a4008dc005014.json"}}, {"family": "Perell\u00f3 Cap\u00f3", "given": "Josep", "initials": "J"}, {"family": "Lete Lasa", "given": "I\u00f1aki", "initials": "I", "orcid": "0000-0002-0266-3970", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c04f7883288f46889b29558128ed0ed6.json"}}, {"family": "Vannuccini", "given": "Silvia", "initials": "S", "orcid": "0000-0001-5790-587X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a60b6384996455eaf747bba3f2f5be0.json"}}, {"family": "Koch", "given": "Martin C", "initials": "MC"}, {"family": "Hildebrandt", "given": "Thomas", "initials": "T", "orcid": "0000-0002-7605-4465", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1f934af7558459d8e228980d1423995.json"}}, {"family": "Calaf", "given": "Joaquim", "initials": "J", "orcid": "0000-0002-2407-7884", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3750306e7cd4f69a59a3120e08c051d.json"}}], "type": "journal article", "published": "2022-01-18", "journal": {"title": "Eur J Contracept Reprod Health Care", "issn": "1473-0782", "pages": "1-5", "issn-l": null}, "abstract": "The COVID-19 global pandemic has led to the death of millions around the world and impacted the overall health of many people. In this article we aim to compare reproductive health indicators in the first 6 months of 2020 to the prior year, as well as explore stress and quality of life during this time.\n\nThis retrospective observational study examined the menstrual cycles of 1159 women who were using a fertility tracking device to record their menstrual cycle and BBT data. We utilised a supplemental mobile application to administer a supplemental survey to collect data on stress and quality of life. Descriptive analyses were conducted with t-tests for two-group comparisons.\n\nStudy participants from 15 countries contributed to a total of 13,194 cycles. 23.1% (268/1159) responded to the survey focussed on assessing psychosocial distress. 44.4% (119/268) of the study participants reported that they had noticed a change in their menstrual cycle, temperature curve, or menstruation in the past 12 months. Cycle analysis found the average cycle length and pre-ovulation phase length was longer in the first 6 months of 2019, while the average days of menstruation was slightly longer in 2020.\n\nOur findings indicate that menstrual cycle indicators changed only slightly in the first 6 months of 2020 but were still statistically significant. We were also able to understand that these study participants had some level of awareness of changes to their menstrual health.", "doi": "10.1080/13625187.2021.2024161", "pmid": "35040737", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-27T07:10:09.391Z", "modified": "2022-01-27T07:35:46.040Z"}, {"entity": "publication", "iuid": "87391f11a89f41ccbdefccfb22773983", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87391f11a89f41ccbdefccfb22773983.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87391f11a89f41ccbdefccfb22773983"}}, "title": "Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function.", "authors": [{"family": "Martin", "given": "Darren P", "initials": "DP"}, {"family": "Lytras", "given": "Spyros", "initials": "S"}, {"family": "Lucaci", "given": "Alexander G", "initials": "AG"}, {"family": "Maier", "given": "Wolfgang", "initials": "W"}, {"family": "Gr\u00fcning", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Shank", "given": "Stephen D", "initials": "SD"}, {"family": "Weaver", "given": "Steven", "initials": "S"}, {"family": "MacLean", "given": "Oscar A", "initials": "OA"}, {"family": "Orton", "given": "Richard J", "initials": "RJ"}, {"family": "Lemey", "given": "Philippe", "initials": "P"}, {"family": "Boni", "given": "Maciej F", "initials": "MF"}, {"family": "Tegally", "given": "Houriiyah", "initials": "H"}, {"family": "Harkins", "given": "Gordon", "initials": "G"}, {"family": "Scheepers", "given": "Cathrine", "initials": "C"}, {"family": "Bhiman", "given": "Jinal N", "initials": "JN"}, {"family": "Everatt", "given": "Josie", "initials": "J"}, {"family": "Amoako", "given": "Daniel G", "initials": "DG"}, {"family": "San", "given": "James Emmanuel", "initials": "JE"}, {"family": "Giandhari", "given": "Jennifer", "initials": "J"}, {"family": "Sigal", "given": "Alex", "initials": "A"}, {"family": "NGS-SA", "given": "", "initials": ""}, {"family": "Williamson", "given": "Carolyn", "initials": "C"}, {"family": "Hsiao", "given": "Nei-Yuan", "initials": "NY"}, {"family": "von Gottberg", "given": "Anne", "initials": "A"}, {"family": "De Klerk", "given": "Arne", "initials": "A"}, {"family": "Shafer", "given": "Robert W", "initials": "RW"}, {"family": "Robertson", "given": "David L", "initials": "DL"}, {"family": "Wilkinson", "given": "Robert J", "initials": "RJ"}, {"family": "Sewell", "given": "B Trevor", "initials": "BT"}, {"family": "Lessells", "given": "Richard", "initials": "R"}, {"family": "Nekrutenko", "given": "Anton", "initials": "A"}, {"family": "Greaney", "given": "Allison J", "initials": "AJ"}, {"family": "Starr", "given": "Tyler N", "initials": "TN"}, {"family": "Bloom", "given": "Jesse D", "initials": "JD"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Wilkinson", "given": "Eduan", "initials": "E"}, {"family": "Gupta", "given": "Ravindra K", "initials": "RK"}, {"family": "de Oliveira", "given": "Tulio", "initials": "T"}, {"family": "Kosakovsky Pond", "given": "Sergei L", "initials": "SL"}], "type": "preprint", "published": "2022-01-18", "journal": {"title": "bioRxiv", "issn-l": null}, "abstract": "Among the 30 non-synonymous nucleotide substitutions in the Omicron S-gene are 13 that have only rarely been seen in other SARS-CoV-2 sequences. These mutations cluster within three functionally important regions of the S-gene at sites that will likely impact (i) interactions between subunits of the Spike trimer and the predisposition of subunits to shift from down to up configurations, (ii) interactions of Spike with ACE2 receptors, and (iii) the priming of Spike for membrane fusion. We show here that, based on both the rarity of these 13 mutations in intrapatient sequencing reads and patterns of selection at the codon sites where the mutations occur in SARS-CoV-2 and related sarbecoviruses, prior to the emergence of Omicron the mutations would have been predicted to decrease the fitness of any genomes within which they occurred. We further propose that the mutations in each of the three clusters therefore cooperatively interact to both mitigate their individual fitness costs, and adaptively alter the function of Spike. Given the evident epidemic growth advantages of Omicron over all previously known SARS-CoV-2 lineages, it is crucial to determine both how such complex and highly adaptive mutation constellations were assembled within the Omicron S-gene, and why, despite unprecedented global genomic surveillance efforts, the early stages of this assembly process went completely undetected.", "doi": "10.1101/2022.01.14.476382", "pmid": "35075456", "labels": {"Category: Omicron VoC": null, "Type: Preprint": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8786225"}], "notes": [], "created": "2022-02-23T11:16:48.684Z", "modified": "2022-02-23T11:17:06.235Z"}, {"entity": "publication", "iuid": "9b93133c2f8a45d1927cf1886ac94805", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b93133c2f8a45d1927cf1886ac94805.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b93133c2f8a45d1927cf1886ac94805"}}, "title": "Potential role of neurofilament in COVID-19 and preeclampsia.", "authors": [{"family": "Samara", "given": "Athina", "initials": "A"}, {"family": "Herlenius", "given": "Eric", "initials": "E"}, {"family": "O' Brien", "given": "Patrick", "initials": "P"}, {"family": "Khalil", "given": "Asma", "initials": "A"}], "type": "news", "published": "2022-01-18", "journal": {"title": "Cell Rep Med", "issn": "2666-3791", "volume": "3", "issue": "1", "pages": "100490", "issn-l": "2666-3791"}, "abstract": "Neurofilament light (NFL) is a promising circulating biomarker in preeclampsia and COVID-19, even without evident neurological complications. Several pathways might contribute to the elevated serum NFL levels seen in both pathologies. Future studies will determine whether NFL is a long COVID marker and delineate NFL's role in COVID-19-associated preeclampsia.", "doi": "10.1016/j.xcrm.2021.100490", "pmid": "35103255", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2666-3791(21)00367-0"}, {"db": "pmc", "key": "PMC8764750"}], "notes": [], "created": "2022-02-06T16:51:21.210Z", "modified": "2022-02-06T16:51:21.225Z"}, {"entity": "publication", "iuid": "e409259f8b5c49bca0bd43c1a5e47f07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e409259f8b5c49bca0bd43c1a5e47f07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e409259f8b5c49bca0bd43c1a5e47f07"}}, "title": "Politicians polarize and experts depolarize public support for COVID-19 management policies across countries.", "authors": [{"family": "Flores", "given": "Alexandra", "initials": "A"}, {"family": "Cole", "given": "Jennifer C", "initials": "JC"}, {"family": "Dickert", "given": "Stephan", "initials": "S"}, {"family": "Eom", "given": "Kimin", "initials": "K"}, {"family": "Jiga-Boy", "given": "Gabriela M", "initials": "GM", "orcid": "0000-0003-3163-8798", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dac90441cd3642eabb3ed61932ba22db.json"}}, {"family": "Kogut", "given": "Tehila", "initials": "T", "orcid": "0000-0001-8652-5112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56c2ee61d26b45c799115f41b68d6c77.json"}}, {"family": "Loria", "given": "Riley", "initials": "R"}, {"family": "Mayorga", "given": "Marcus", "initials": "M", "orcid": "0000-0001-5471-0655", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d12c67fe7be433282cdecf395edca4a.json"}}, {"family": "Pedersen", "given": "Eric J", "initials": "EJ"}, {"family": "Pereira", "given": "Beatriz", "initials": "B", "orcid": "0000-0002-1091-0943", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b713e52b7d4744f2bd2de606a92dae2f.json"}}, {"family": "Rubaltelli", "given": "Enrico", "initials": "E", "orcid": "0000-0002-7521-755X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2283c6a303c24124a700b154b2d62b97.json"}}, {"family": "Sherman", "given": "David K", "initials": "DK"}, {"family": "Slovic", "given": "Paul", "initials": "P", "orcid": "0000-0002-7473-6403", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e42d731725348998fcff156270435f5.json"}}, {"family": "V\u00e4stfj\u00e4ll", "given": "Daniel", "initials": "D"}, {"family": "Van Boven", "given": "Leaf", "initials": "L", "orcid": "0000-0003-4187-8779", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd5678aef638457dab8264e41775c3dc.json"}}], "type": "journal article", "published": "2022-01-18", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "119", "issue": "3", "issn-l": "0027-8424"}, "abstract": "Political polarization impeded public support for policies to reduce the spread of COVID-19, much as polarization hinders responses to other contemporary challenges. Unlike previous theory and research that focused on the United States, the present research examined the effects of political elite cues and affective polarization on support for policies to manage the COVID-19 pandemic in seven countries (n = 12,955): Brazil, Israel, Italy, South Korea, Sweden, the United Kingdom, and the United States. Across countries, cues from political elites polarized public attitudes toward COVID-19 policies. Liberal and conservative respondents supported policies proposed by ingroup politicians and parties more than the same policies from outgroup politicians and parties. Respondents disliked, distrusted, and felt cold toward outgroup political elites, whereas they liked, trusted, and felt warm toward both ingroup political elites and nonpartisan experts. This affective polarization was correlated with policy support. These findings imply that policies from bipartisan coalitions and nonpartisan experts would be less polarizing, enjoying broader public support. Indeed, across countries, policies from bipartisan coalitions and experts were more widely supported. A follow-up experiment replicated these findings among US respondents considering international vaccine distribution policies. The polarizing effects of partisan elites and affective polarization emerged across nations that vary in cultures, ideologies, and political systems. Contrary to some propositions, the United States was not exceptionally polarized. Rather, these results suggest that polarizing processes emerged simply from categorizing people into political ingroups and outgroups. Political elites drive polarization globally, but nonpartisan experts can help resolve the conflicts that arise from it.", "doi": "10.1073/pnas.2117543119", "pmid": "35042779", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2117543119"}], "notes": [], "created": "2022-01-27T07:06:55.025Z", "modified": "2022-01-27T07:06:55.297Z"}, {"entity": "publication", "iuid": "be6c92969d4f4a0eb3c57bee4076a14e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be6c92969d4f4a0eb3c57bee4076a14e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be6c92969d4f4a0eb3c57bee4076a14e"}}, "title": "Impact of the COVID-19 pandemic on the incidence and mortality of hospital-onset bloodstream infection: a cohort study.", "authors": [{"family": "Valik", "given": "John Karlsson", "initials": "JK", "orcid": "0000-0002-4521-1886", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eac431272ad4d8eb13c8d56ddef182c.json"}}, {"family": "Hedberg", "given": "Pontus", "initials": "P"}, {"family": "Holmberg", "given": "Fredrik", "initials": "F"}, {"family": "van der Werff", "given": "Suzanne Desir\u00e9e", "initials": "SD"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2022-01-18", "journal": {"title": "BMJ Qual Saf", "issn": "2044-5423", "issn-l": null}, "abstract": "The COVID-19 pandemic burdens hospitals, but consequences for quality of care outcomes such as healthcare-associated infections are largely unknown. This cohort included all adult hospital episodes (n=186 945) at an academic centre between January 2018 and January 2021. Data were collected from the hospitals' electronic health record data repository. Hospital-onset bloodstream infection (HOB) was defined as any positive blood culture obtained \u226548 hours after admission classified based on microbiological and hospital administrative data. Subgroup analyses were performed with exclusion of potential contaminant bacteria. The cohort was divided into three groups: controls (prepandemic period), non-COVID-19 (pandemic period) and COVID-19 (pandemic period) based on either PCR-confirmed SARS-CoV-2 infections from respiratory samples or International Classification of Diseases 10th Revision diagnoses U071 and U72 at discharge. Adjusted incidence rate ratios (aIRR) and risk of death in patients with HOB were compared between the prepandemic and pandemic periods using Poisson and logistic regression. The incidence of HOB was increased for the COVID-19 group compared with the prepandemic period (aIRR 3.34, 95% CI 2.97 to 3.75). In the non-COVID-19 group, the incidence was slightly increased compared with prepandemic levels (aIRR 1.20, 95% CI 1.08 to 1.32), but the difference decreased when excluding potential contaminant bacteria (aIRR 1.15, 95% CI 1.00 to 1.31, p=0.04). The risk of dying increased for both the COVID-19 group (adjusted odds ratio (aOR) 2.44, 95% CI 1.75 to 3.38) and the non-COVID-19 group (aOR 1.63, 95% CI 1.22 to 2.16) compared with the prepandemic controls. These findings were consistent also when excluding potential contaminants. In summary, we observed a higher incidence of HOB during the COVID-19 pandemic, and the mortality risk associated with HOB was greater, compared with the prepandemic period. Results call for specific attention to quality of care during the pandemic.", "doi": "10.1136/bmjqs-2021-014243", "pmid": "35042764", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjqs-2021-014243"}], "notes": [], "created": "2022-01-27T07:07:10.389Z", "modified": "2022-01-27T07:07:10.470Z"}, {"entity": "publication", "iuid": "782143d0f4d244e4864d0676fde7793d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/782143d0f4d244e4864d0676fde7793d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/782143d0f4d244e4864d0676fde7793d"}}, "title": "How has the University Community Been Coping During the COVID-19 Pandemic? An Iranian Survey.", "authors": [{"family": "Ahmadi", "given": "Fereshteh", "initials": "F"}, {"family": "Cetrez", "given": "\u00d6nver A", "initials": "\u00d6A"}, {"family": "Akhavan", "given": "Sharareh", "initials": "S"}, {"family": "Khodayarifard", "given": "Mohammad", "initials": "M"}, {"family": "Zandi", "given": "Saeid", "initials": "S"}], "type": "journal article", "published": "2022-01-18", "journal": {"title": "Front Sociol", "issn": "2297-7775", "issn-l": null, "volume": "6", "issue": null, "pages": "645670"}, "abstract": "Objectives: The present study, one of the first to look at COVID-19 and coping in Iran, aimed at mapping, describing and understanding the coping methods academics employ as protective resources to deal with the psychological challenges and social isolation during the COVID-19 pandemic. We specifically aimed at identifying the meaning-making coping methods used and understanding the influence of culture. The guiding research question has been: Are there differences in meaning-making coping methods by gender, age group, work/student status, and place of residence? Design: The study, which used convenience sampling, was a quantitative inquiry. It employed a modified version of the RCOPE scale among faculty/staff members and students in Iran (n = 196, 75% women). Results: The most frequently used coping method among all subgroups of the study sample was thinking that life is part of a greater whole, followed by praying to Allah/God. The least used coping methods were the negative religious ones. Gender differences were found for being alone and contemplating, stronger for men. Thinking that life is part of a greater whole was found mainly among on-campus students. Praying to Allah/God was most common among the youngest staff and students, as well as among women. Two segments of respondents were discovered-the Theists and Non-theists-where the former used more religious coping methods, were more likely to be women, older staff and students, on-campus students, married, have children, and lived in capital. Conclusions: Our conclusion is that the RCOPE methods, which include religious and spiritual meaning-making methods, are of great importance to the studied Iranian informants. However, they use some secular existential meaning-making coping strategies too. This is explained by the role of religion in the larger orientation system and frame of reference in parallel with a secular worldview. Further, a sharp distinction between religious and secular worldviews was not found, which is explained by the fact that secular norms are hardly internalized in ways of thinking in Iran.", "doi": "10.3389/fsoc.2021.645670", "pmid": "35118154", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "645670"}, {"db": "pmc", "key": "PMC8804233"}], "notes": [], "created": "2022-02-06T16:46:47.401Z", "modified": "2022-11-22T05:40:56.916Z"}, {"entity": "publication", "iuid": "8e579aec7c4344b894b2a8a236a106ba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e579aec7c4344b894b2a8a236a106ba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e579aec7c4344b894b2a8a236a106ba"}}, "title": "Can They Stay or Will They Go? A Cross Sectional Study of Managers' Attitudes towards Their Senior Employees.", "authors": [{"family": "Nilsson", "given": "Kerstin", "initials": "K", "orcid": "0000-0002-3193-205X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81335f480e0d4c7590701b5a164c269e.json"}}, {"family": "Nilsson", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2022-01-18", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "3", "issn-l": null}, "abstract": "A larger amount of older people need to participate in working life due to the global demographic change. It is the employer, through the manager, who enables employees to have access to measures in the workplace that facilitate and enable a sustainable extended working life. The aim of this study was to evaluate work life factors associated with managers believing their employees can work versus wanting to work until age 65 or older. This cross-sectional study included 249 managers in the Swedish municipality sector. Logistic regression analysis was used to investigate associations between different univariate estimates and in data modelling using the SwAge-model. The result stated that 79% of managers believed their employees 'can' work and 58% of managers believed their employees 'want to' work until age 65 or older. Health, physical work environment, skills and competence are associated the strongest to managers believing employees 'can' work until age 65 or older. Insufficient social support at work and lacking possibilities for relocations associated the strongest to managers believing employees would not 'want to' work until age 65 or older. Though, several countries (especially in Europe) have included in their social policy measures that retirement age be increased after 65, proposing ages approaching 70. When these proposals become laws, through obligation, people will have no choice (if they want to or if they can continue working). However, people's attitudes to work may be different (especially after the COVID-19 pandemic), and this analysis of the participating managers' attitudes showed there is a difference between why employees 'can' versus 'want' to work respectively. Therefore, different strategies may be needed to contribute to employees both being able to and willing to participate in working life until an older age. These findings on managers' perspectives, regarding whether they believe employees would be able to versus would want to work and the SwAge-model, will hopefully contribute to an increased understanding of organisational actions and measures in the process of creating a sustainable extended working life and to increase senior employees' employability.", "doi": "10.3390/ijerph19031057", "pmid": "35162080", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19031057"}], "notes": [], "created": "2022-02-17T06:10:01.874Z", "modified": "2022-02-17T06:10:15.286Z"}, {"entity": "publication", "iuid": "90a1865683244d27a10a4f43f5f9bd8d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90a1865683244d27a10a4f43f5f9bd8d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90a1865683244d27a10a4f43f5f9bd8d"}}, "title": "COVID-19 Severity and Cardiovascular Disease: An Inseparable Link.", "authors": [{"family": "Henein", "given": "Michael Y", "initials": "MY", "orcid": "0000-0002-6089-5614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe79bb10eb4348948599443b7b396faf.json"}}, {"family": "Cameli", "given": "Matteo", "initials": "M", "orcid": "0000-0003-3872-8964", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e64899d051a84cd8a0cac5f503e03251.json"}}, {"family": "Pastore", "given": "Maria Concetta", "initials": "MC", "orcid": "0000-0002-7223-141X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/55e79d1bf0294864ae1cdb57aa4a4844.json"}}, {"family": "Mandoli", "given": "Giulia Elena", "initials": "GE", "orcid": "0000-0002-3184-3006", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc927b7843b44bdd87232563c7faff19.json"}}], "type": "editorial", "published": "2022-01-18", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "11", "issue": "3", "issn-l": "2077-0383"}, "abstract": "The COVID-19 pandemic is a global health issue that has so far affected over 250 million people worldwide [...].", "doi": "10.3390/jcm11030479", "pmid": "35159931", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "jcm11030479"}], "notes": [], "created": "2022-02-17T06:11:18.116Z", "modified": "2022-02-17T06:11:32.211Z"}, {"entity": "publication", "iuid": "6cff8b952d0f4794bf399b05db141eb3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6cff8b952d0f4794bf399b05db141eb3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6cff8b952d0f4794bf399b05db141eb3"}}, "title": "Perceived Changes in Sexual Interest and Distress About Discrepant Sexual Interest During the First Phase of COVID-19 Pandemic: A Multi-Country Assessment in Cohabiting Partnered Individuals.", "authors": [{"family": "\u0160tulhofer", "given": "Aleksandar", "initials": "A", "orcid": "0000-0001-5138-3644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1eaa60cb1a874757ab9306915557c39c.json"}}, {"family": "Mehuli\u0107", "given": "Jasmina", "initials": "J"}, {"family": "Briken", "given": "Peer", "initials": "P"}, {"family": "Klapilov\u00e1", "given": "Kate\u0159ina", "initials": "K"}, {"family": "de Graaf", "given": "Hanneke", "initials": "H"}, {"family": "Carvalheira", "given": "Ana Alexandra", "initials": "AA"}, {"family": "L\u00f6fgren-M\u00e5rtenson", "given": "Charlotta", "initials": "C"}, {"family": "Nobre", "given": "Pedro", "initials": "P"}, {"family": "Chollier", "given": "Marie", "initials": "M"}, {"family": "K\u00f6se", "given": "\u00d6zlem", "initials": "\u00d6"}, {"family": "Elmerstig", "given": "Eva", "initials": "E"}, {"family": "Lan\u00e7on", "given": "Christophe", "initials": "C"}, {"family": "Pl\u00e1\u0161ilov\u00e1", "given": "Leona", "initials": "L"}, {"family": "Schr\u00f6der", "given": "Johanna", "initials": "J"}], "type": "journal article", "published": "2022-01-17", "journal": {"title": "Arch Sex Behav", "issn": "1573-2800", "issn-l": "0004-0002"}, "abstract": "Due to COVID-19 pandemic, different restrictive measures in terms of physical distancing and lockdowns have been introduced in most European countries, affecting all facets of social life. Currently, little is known about how partnered individuals perceive changes in their sexual life during this complex emergency. This study explored retrospectively assessed changes in sexual interest for one's partner and levels of distress related to perceived sexual interest discrepancy during the first phase of the pandemic in a large-scale online sample of partnered individuals (n = 4813; Mage = 38.5 years, SD = 10.74) recruited between May and July 2020 in seven European Union countries and Turkey. We also examined the possible role of approach/avoidance motives for sex in reported changes in sexual interest and associated distress. Most participants (53%) reported no change in their sexual interest during the pandemic, followed by those who reported an increase (28.5%). The pattern was similar across the eight countries. Distress about discrepant sexual interest, which was only weakly related to changes in sexual interest, was significantly associated with relationship quality and emotional closeness with a partner, coping with and worrying about the pandemic, and specific motivation for sex. In contrast to avoidant and relationship-focused approach motivation, ego-focused approach motivation was related to stable sexual interest during the pandemic. The current study contributes to the understanding of the link between sexual interest and complex emergencies. Considering that the COVID-19 pandemic continues, the reported experiences and perceptions are prone to change.", "doi": "10.1007/s10508-021-02279-z", "pmid": "35039982", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10508-021-02279-z"}, {"db": "pmc", "key": "PMC8763301"}], "notes": [], "created": "2022-01-27T07:36:01.051Z", "modified": "2022-01-27T07:36:01.110Z"}, {"entity": "publication", "iuid": "65f8bc7f05004142a11717a6c44b2815", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65f8bc7f05004142a11717a6c44b2815.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65f8bc7f05004142a11717a6c44b2815"}}, "title": "Multiomics integration-based molecular characterizations of COVID-19.", "authors": [{"family": "Li", "given": "Chuan-Xing", "initials": "CX", "orcid": "0000-0003-2189-5010", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b85683a869f446be80700b375582d4d3.json"}}, {"family": "Gao", "given": "Jing", "initials": "J", "orcid": "0000-0002-7732-456X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ec4995699874336b6f0eca4f9812fd5.json"}}, {"family": "Zhang", "given": "Zicheng", "initials": "Z"}, {"family": "Chen", "given": "Lu", "initials": "L"}, {"family": "Li", "given": "Xun", "initials": "X"}, {"family": "Zhou", "given": "Meng", "initials": "M"}, {"family": "Wheelock", "given": "\u00c5sa M", "initials": "\u00c5M"}], "type": "journal article", "published": "2022-01-17", "journal": {"title": "Brief Bioinform", "issn": "1477-4054", "volume": "23", "issue": "1", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rapidly became a global health challenge, leading to unprecedented social and economic consequences. The mechanisms behind the pathogenesis of SARS-CoV-2 are both unique and complex. Omics-scale studies are emerging rapidly and offer a tremendous potential to unravel the puzzle of SARS-CoV-2 pathobiology, as well as moving forward with diagnostics, potential drug targets, risk stratification, therapeutic responses, vaccine development and therapeutic innovation. This review summarizes various aspects of understanding multiomics integration-based molecular characterizations of COVID-19, which to date include the integration of transcriptomics, proteomics, genomics, lipidomics, immunomics and metabolomics to explore virus targets and developing suitable therapeutic solutions through systems biology tools. Furthermore, this review also covers an abridgment of omics investigations related to disease pathogenesis and virulence, the role of host genetic variation and a broad array of immune and inflammatory phenotypes contributing to understanding COVID-19 traits. Insights into this review, which combines existing strategies and multiomics integration profiling, may help further advance our knowledge of COVID-19.", "doi": "10.1093/bib/bbab485", "pmid": "34864875", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC8769889"}, {"db": "pii", "key": "6447675"}], "notes": [], "created": "2023-01-13T13:28:31.791Z", "modified": "2023-07-13T11:29:23.254Z"}, {"entity": "publication", "iuid": "92bd885f2293490888030e991224833d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/92bd885f2293490888030e991224833d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/92bd885f2293490888030e991224833d"}}, "title": "Healthcare use in 700 000 children and adolescents for six months after covid-19: before and after register based cohort study.", "authors": [{"family": "Magnusson", "given": "Karin", "initials": "K", "orcid": "0000-0003-4851-5794", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2fe6a28f36f40a998b8c9fc3c5ebe73.json"}}, {"family": "Skyrud", "given": "Katrine Damgaard", "initials": "KD"}, {"family": "Suren", "given": "P\u00e5l", "initials": "P"}, {"family": "Greve-Isdahl", "given": "Margrethe", "initials": "M"}, {"family": "St\u00f8rdal", "given": "Ketil", "initials": "K"}, {"family": "Kristoffersen", "given": "Doris Tove", "initials": "DT"}, {"family": "Telle", "given": "Kjetil", "initials": "K"}], "type": "journal article", "published": "2022-01-17", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "376", "pages": "e066809", "issn-l": null}, "abstract": "To explore whether and for how long use of healthcare services is increased among children and adolescents after covid-19.\n\nBefore and after register based study.\n\nGeneral population of Norway.\n\nNorwegians aged 1-19 years (n=706 885) who were tested for SARS-CoV-2 from 1 August 2020 to 1 February 2021 (n=10 279 positive, n=275 859 negative) or not tested (n=420 747) and were not admitted to hospital, by age groups 1-5, 6-15, and 16-19 years.\n\nMonthly percentages of all cause and cause specific healthcare use in primary care (general practitioner, emergency ward) and specialist care (outpatient, inpatient) from six months before to about six months after the week of being tested for SARS-CoV-2, using a difference-in-differences approach.\n\nA substantial short term relative increase in primary care use was observed for participants during the first month after a positive SARS-CoV-2 test result compared with those who tested negative (age 1-5 years: 339%, 95% confidence interval 308% to 369%; 6-15 years: 471%, 450% to 491%; 16-19 years: 401%, 380% to 422%). Use of primary care for the younger age groups was still increased at two months (1-5 years: 22%, 4% to 40%; 6-15 years: 14%, 2% to 26%) and three months (1-5 years: 26%, 7% to 46%, 6-15 years: 15%, 3% to 28%), but not for the oldest group (16-19 years: 11%, -2% to 24% and 6%, -7% to 19%, respectively). Children aged 1-5 years who tested positive also showed a minor long term (\u22646 months) relative increase in primary care use (13%, -0% to 26%) that was not observed for the older age groups, compared with same aged children who tested negative. Results were similar yet the age differences less pronounced compared with untested controls. For all age groups, the increase in primary care visits was due to respiratory and general or unspecified conditions. No increased use of specialist care was observed.\n\nCovid-19 among children and adolescents was found to have limited impact on healthcare services in Norway. Preschool aged children might take longer to recover (3-6 months) than primary or secondary school students (1-3 months), usually because of respiratory conditions.", "doi": "10.1136/bmj-2021-066809", "pmid": "35039315", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8762452"}], "notes": [], "created": "2022-01-27T07:38:14.686Z", "modified": "2022-01-27T07:38:14.743Z"}, {"entity": "publication", "iuid": "7dd32d0115a74a9aa9d819dcd6f91cf8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7dd32d0115a74a9aa9d819dcd6f91cf8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7dd32d0115a74a9aa9d819dcd6f91cf8"}}, "title": "Severe multisystem inflammatory syndrome (MIS-C/A) after confirmed SARS-CoV-2 infection: a report of four adult cases", "authors": [{"family": "Sansone", "given": "M", "initials": "M"}, {"family": "Studahl", "given": "M", "initials": "M"}, {"family": "Berg", "given": "S", "initials": "S"}, {"family": "Gissl\u00e9n", "given": "M", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}, {"family": "Sundell", "given": "N", "initials": "N"}], "type": "journal-article", "published": "2022-01-16", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4235", "issn-l": null, "volume": null, "issue": null, "pages": "1-6"}, "abstract": "Multisystem inflammatory syndrome (MIS) triggered by a recent SARS-Cov-2 infection has been recognised worldwide. Although predominantly affecting children (MIS-C), similar presentations have been reported among adults (MIS-A).\n\nA retrospective case series describing four critically ill patients with MIS-C/A diagnosed between January and April 2021 at Sahlgrenska University Hospital, Gothenburg, Sweden. Clinical presentation, laboratory and radiological findings, treatment and outcome are reported.\n\nCases occurred in previously healthy patients with a history of laboratory-confirmed mild SARS-CoV-2 infection four to seven weeks earlier. The median age was 24 years (range 19-43) and 3/4 were male. All fulfilled suggested MIS-C/A criteria according to the US Centre for Disease Control and all required care at an intensive care unit. Treatment was initiated with intravenous immunoglobulin, interleukin-1-receptor antagonists, and pulse steroids in 3/4 cases which resulted in rapid clinical improvement. No severe complications were noticed in any case during a three-month follow-up period.\n\nMIS-C/A should be considered, irrespective of age, in patients with fever, hyperinflammation and multiple organ system involvements emerging weeks after COVID-19. Previously suggested treatment regimens for MIS-C seem to be applicable also for MIS-A.", "doi": "10.1080/23744235.2021.2025422", "pmid": "35034549", "labels": {"Category: Health": null, "Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [], "notes": [], "created": "2022-01-27T07:41:24.997Z", "modified": "2022-02-06T17:32:32.457Z"}, {"entity": "publication", "iuid": "966230056df94b2e846d8626a6add138", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/966230056df94b2e846d8626a6add138.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/966230056df94b2e846d8626a6add138"}}, "title": "Long-term exposure to ambient air pollution and incidence of depression: A population-based cohort study in China.", "authors": [{"family": "Wei", "given": "Fang", "initials": "F"}, {"family": "Yu", "given": "Zhebin", "initials": "Z"}, {"family": "Zhang", "given": "Xinhan", "initials": "X"}, {"family": "Wu", "given": "Mengyin", "initials": "M"}, {"family": "Wang", "given": "Jianbing", "initials": "J"}, {"family": "Shui", "given": "Liming", "initials": "L"}, {"family": "Lin", "given": "Hongbo", "initials": "H"}, {"family": "Jin", "given": "Mingjuan", "initials": "M"}, {"family": "Tang", "given": "Mengling", "initials": "M"}, {"family": "Chen", "given": "Kun", "initials": "K"}], "type": "journal article", "published": "2022-01-15", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "volume": "804", "pages": "149986", "issn-l": "0048-9697"}, "abstract": "Long-term exposure to ambient air pollution was linked to depression incidence, although the results were limited and inconsistent.\n\nTo investigate the effects of long-term air pollution exposure on depression risk prospectively in China.\n\nThe present study used data from Yinzhou Cohort on adults without depression at baseline, and followed up until April 2020. Two-year moving average concentrations of particulate matter with a diameter \u2264 2.5 \u03bcm (PM2.5), \u226410 \u03bcm (PM10) and nitrogen dioxide (NO2) were measured using land-use regression (LUR) models for each participant. Depression cases were ascertained using the Health Information System (HIS) of the local health administration by linking the unique identifiers. We conducted Cox regression models with time-varying exposures to estimate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of depression with each pollutant, after adjusting for a sequence of individual covariates as demographic characteristics, lifestyles, and comorbidity. Besides, physical activity, baseline potential depressive symptoms, cancer status, COVID-19 pandemic, different outcome definitions and air pollution exposure windows were considered in sensitivity analyses.\n\nAmong the 30,712 adults with a mean age of 62.22 \u00b1 11.25, 1024 incident depression cases were identified over totaling 98,619 person-years of observation. Interquartile range increments of the air pollutants were associated with increased risks of depression, and the corresponding HRs were 1.59 (95%CI: 1.46, 1.72) for PM2.5, 1.49 (95%CI: 1.35, 1.64) for PM10 and 1.58 (95%CI: 1.42, 1.77) for NO2. Subgroup analyses suggested that participants without taking any protective measures towards air pollution were more susceptible. The results remained robust in all sensitivity analyses.\n\nLong-term exposure to ambient air pollution was identified as a risk factor for depression onset. Strategies to reduce air pollution are necessary to decrease the disease burden of depression.", "doi": "10.1016/j.scitotenv.2021.149986", "pmid": "34798713", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(21)05061-0"}], "notes": [], "created": "2021-11-26T14:04:59.512Z", "modified": "2021-11-26T14:04:59.526Z"}, {"entity": "publication", "iuid": "5eddcc6107ba40b295898a133c0168eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5eddcc6107ba40b295898a133c0168eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5eddcc6107ba40b295898a133c0168eb"}}, "title": "Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2.", "authors": [{"family": "Bahnan", "given": "Wael", "initials": "W"}, {"family": "Wrighton", "given": "Sebastian", "initials": "S"}, {"family": "Sundwall", "given": "Martin", "initials": "M"}, {"family": "Bl\u00e4ckberg", "given": "Anna", "initials": "A"}, {"family": "Larsson", "given": "Olivia", "initials": "O"}, {"family": "H\u00f6glund", "given": "Urban", "initials": "U"}, {"family": "Khakzad", "given": "Hamed", "initials": "H"}, {"family": "Godzwon", "given": "Magdalena", "initials": "M"}, {"family": "Walle", "given": "Maria", "initials": "M"}, {"family": "Elder", "given": "Elisabeth", "initials": "E"}, {"family": "Strand", "given": "Anna S\u00f6derlund", "initials": "AS"}, {"family": "Happonen", "given": "Lotta", "initials": "L"}, {"family": "Andr\u00e9", "given": "Oscar", "initials": "O"}, {"family": "Ahnlide", "given": "Johannes Kumra", "initials": "JK"}, {"family": "Hellmark", "given": "Thomas", "initials": "T"}, {"family": "Wendel-Hansen", "given": "Vidar", "initials": "V"}, {"family": "Wallin", "given": "Robert Pa", "initials": "RP"}, {"family": "Malmst\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Malmstr\u00f6m", "given": "Lars", "initials": "L"}, {"family": "Ohlin", "given": "Mats", "initials": "M"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}, {"family": "Nordenfelt", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "12", "issue": null, "pages": "808932"}, "abstract": "Spike-specific antibodies are central to effective COVID19 immunity. Research efforts have focused on antibodies that neutralize the ACE2-Spike interaction but not on non-neutralizing antibodies. Antibody-dependent phagocytosis is an immune mechanism enhanced by opsonization, where typically, more bound antibodies trigger a stronger phagocyte response. Here, we show that Spike-specific antibodies, dependent on concentration, can either enhance or reduce Spike-bead phagocytosis by monocytes independently of the antibody neutralization potential. Surprisingly, we find that both convalescent patient plasma and patient-derived monoclonal antibodies lead to maximum opsonization already at low levels of bound antibodies and is reduced as antibody binding to Spike protein increases. Moreover, we show that this Spike-dependent modulation of opsonization correlate with the outcome in an experimental SARS-CoV-2 infection model. These results suggest that the levels of anti-Spike antibodies could influence monocyte-mediated immune functions and propose that non-neutralizing antibodies could confer protection to SARS-CoV-2 infection by mediating phagocytosis.", "doi": "10.3389/fimmu.2021.808932", "pmid": "35095897", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Category: Vaccines": null, "Research Area: Vaccine": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC8796240"}], "notes": [], "created": "2022-01-18T15:28:04.664Z", "modified": "2022-02-08T19:18:01.159Z"}, {"entity": "publication", "iuid": "0d6ac289da3a4cb4bb7423c49a0cf64a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d6ac289da3a4cb4bb7423c49a0cf64a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d6ac289da3a4cb4bb7423c49a0cf64a"}}, "title": "SARS-CoV-2 phase I transmission and mutability linked to the interplay of climatic variables: a global observation on the pandemic spread.", "authors": [{"family": "Sabarathinam", "given": "Chidambaram", "initials": "C"}, {"family": "Mohan Viswanathan", "given": "Prasanna", "initials": "P"}, {"family": "Senapathi", "given": "Venkatramanan", "initials": "V"}, {"family": "Karuppannan", "given": "Shankar", "initials": "S"}, {"family": "Samayamanthula", "given": "Dhanu Radha", "initials": "DR"}, {"family": "Gopalakrishnan", "given": "Gnanachandrasamy", "initials": "G"}, {"family": "Alagappan", "given": "Ramanathan", "initials": "R"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Environ Sci Pollut Res Int", "issn": "1614-7499", "issn-l": null}, "abstract": "The study aims to determine the impact of global meteorological parameters on SARS-COV-2, including population density and initiation of lockdown in twelve different countries. The daily trend of these parameters and COVID-19 variables from February 15th to April 25th, 2020, were considered. Asian countries show an increasing trend between infection rate and population density. A direct relationship between the time-lapse of the first infected case and the period of suspension of movement controls the transmissivity of COVID-19 in Asian countries. The increase in temperature has led to an increase in COVID-19 spread, while the decrease in humidity is consistent with the trend in daily deaths during the peak of the pandemic in European countries. Countries with 65\u00b0F temperature and 5 mm rainfall have a negative impact on COVID-19 spread. Lower oxygen availability in the atmosphere, fine droplets of submicron size together with infectious aerosols, and low wind speed have contributed to the increase in total cases and mortality in Germany and France. The onset of the D614G mutation and subsequent changes to D614 before March, later G614 in mid-March, and S943P, A831V, D839/Y/N/E in April were observed in Asian and European countries. The results of the correlation and factor analysis show that the COVID-19 cases and the climatic factors are significantly correlated with each other. The optimum meteorological conditions for the prevalence of G614 were identified. It was observed that the complex interaction of global meteorological factors and changes in the mutational form of CoV-2 phase I influenced the daily mortality rate along with other comorbid factors. The results of this study could help the public and policymakers to create awareness of the COVID-19 pandemic.", "doi": "10.1007/s11356-021-17481-8", "pmid": "35028838", "labels": {"Category: Genomics & transcriptomics": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11356-021-17481-8"}, {"db": "pmc", "key": "PMC8758228"}], "notes": [], "created": "2022-01-27T08:03:53.271Z", "modified": "2022-01-27T08:03:53.308Z"}, {"entity": "publication", "iuid": "26568a5562674a6aa0dba0ae047d4f41", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26568a5562674a6aa0dba0ae047d4f41.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26568a5562674a6aa0dba0ae047d4f41"}}, "title": "SARS-CoV-2 outbreaks in hospitals and long-term care facilities in Germany: a national observational study.", "authors": [{"family": "Suwono", "given": "Beneditta", "initials": "B"}, {"family": "Steffen", "given": "Annika", "initials": "A"}, {"family": "Schweickert", "given": "Birgitta", "initials": "B"}, {"family": "Sch\u00f6nfeld", "given": "Viktoria", "initials": "V"}, {"family": "Brandl", "given": "Michael", "initials": "M"}, {"family": "Sandfort", "given": "Mirco", "initials": "M"}, {"family": "Willrich", "given": "Niklas", "initials": "N"}, {"family": "Eckmanns", "given": "Tim", "initials": "T"}, {"family": "Haller", "given": "Sebastian", "initials": "S"}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "pages": "100303", "issn-l": null}, "abstract": "Outbreaks of coronavirus disease (COVID-19) in hospitals and long-term care facilities (LTCFs) pose serious public health threats. We analysed how frequency and size of SARS-CoV-2 outbreaks in hospitals and LTCFs have altered since the beginning of the pandemic, in particular since the start of the vaccination campaign.\n\nWe used mandatory notification data on SARS-CoV-2 cases in Germany and stratified by outbreak cases in hospitals and LTCFs. German vaccination coverage data were analysed. We studied the association of the occurrence of SARS-CoV-2 outbreaks and outbreak cases with SARS-CoV-2 cases in Germany throughout the four pandemic waves. We built also counterfactual scenarios with the first pandemic wave as the baseline.\n\nBy 21 September 2021, there were 4,147,387 SARS-CoV-2 notified cases since March 2020. About 20% of these cases were reported as being related to an outbreak, with 1% of the cases in hospitals and 4% in LTCFs. The median number of outbreak cases in the different phases was smaller (\u22645) in hospitals than in LTCFs (>10). In the first and second pandemic waves, we observed strong associations in both facility types between SARS-CoV-2 outbreak cases and total number of notified SARS-CoV-2 cases. However, during the third pandemic wave we observed a decline in outbreak cases in both facility types and only a weak association between outbreak cases and all cases.\n\nThe vaccination campaign and non-pharmaceutical interventions have been able to protect vulnerable risk groups in hospitals and LTCFs.\n\nNo specific funding.", "doi": "10.1016/j.lanepe.2021.100303", "pmid": "35043103", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00289-1"}, {"db": "pmc", "key": "PMC8759004"}], "notes": [], "created": "2022-01-27T07:06:39.744Z", "modified": "2022-01-27T07:06:39.757Z"}, {"entity": "publication", "iuid": "d5b05f520ab34ed8b3f72d7f97878f26", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5b05f520ab34ed8b3f72d7f97878f26.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5b05f520ab34ed8b3f72d7f97878f26"}}, "title": "Perceptions of changes in practice patterns and patient care among heart failure nurses during the COVID-19 pandemic.", "authors": [{"family": "Prasun", "given": "Marilyn A", "initials": "MA"}, {"family": "Blakeman", "given": "John R", "initials": "JR"}, {"family": "Vuckovic", "given": "Karen", "initials": "K"}, {"family": "Kim", "given": "MyoungJin", "initials": "M"}, {"family": "Albert", "given": "Nancy", "initials": "N"}, {"family": "Stamp", "given": "Kelly D", "initials": "KD"}, {"family": "Jaarsma", "given": "Tiny", "initials": "T"}, {"family": "Riegel", "given": "Barbara", "initials": "B"}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Heart Lung", "issn": "1527-3288", "volume": "52", "pages": "152-158", "issn-l": null}, "abstract": "The Coronavirus (COVID-19) had a profound impact on the delivery of care in both hospital and outpatient settings across the United States. Patients with heart failure (HF) and healthcare providers had to abruptly adapt.\n\nTo describe how the COVID-19 pandemic affected practice patterns of HF nurses.\n\nPracticing HF nurses completed a cross-sectional, anonymous, web-based survey of perceptions of HF practice. Analyses involved descriptive and comparative statistics.\n\nOf 171 nurses who completed surveys, outpatient HF visits decreased and 63.2% added telehealth visits. Despite spending about 29 min educating patients during visits, 27.5% of nurses perceived that the pandemic decreased patients' abilities to provide optimal self-care. Nurses reported decreased ability to collect objective data (62.4%; n = 78), although subjective assessment stayed the same (41.6%; n = 52).\n\nNurses' practice patterns provided insight into patient care changes made during COVID-19. Most core components of HF management were retained, but methods of delivery during the pandemic differed.", "doi": "10.1016/j.hrtlng.2022.01.004", "pmid": "35091263", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0147-9563(22)00005-X"}], "notes": [], "created": "2022-01-31T11:42:44.061Z", "modified": "2022-01-31T11:42:44.095Z"}, {"entity": "publication", "iuid": "35b02b7fb97748b09597e7d962742b69", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/35b02b7fb97748b09597e7d962742b69.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/35b02b7fb97748b09597e7d962742b69"}}, "title": "Patients' and clinicians' perspectives on the primary care consultations for acute respiratory infections during the first wave of the COVID-19 pandemic: an eight-country qualitative study in Europe.", "authors": [{"family": "Wanat", "given": "Marta", "initials": "M"}, {"family": "Hoste", "given": "Melanie Eugenie", "initials": "ME"}, {"family": "Gobat", "given": "Nina Helene", "initials": "NH"}, {"family": "Anastasaki", "given": "Marilena", "initials": "M"}, {"family": "B\u00f6hmer", "given": "Femke", "initials": "F"}, {"family": "Chlabicz", "given": "Slawomir", "initials": "S"}, {"family": "Colliers", "given": "Annelies", "initials": "A"}, {"family": "Farrell", "given": "Karen", "initials": "K"}, {"family": "Hollerbach", "given": "Sophie", "initials": "S"}, {"family": "Karkana", "given": "Maria-Nefeli", "initials": "MN"}, {"family": "Kinsman", "given": "John", "initials": "J"}, {"family": "Lionis", "given": "Christos", "initials": "C"}, {"family": "Marcinowicz", "given": "Ludmila", "initials": "L"}, {"family": "Reinhardt", "given": "Katrin", "initials": "K"}, {"family": "Skoglund", "given": "Ingmarie", "initials": "I"}, {"family": "Sundvall", "given": "P\u00e4r-Daniel", "initials": "PD"}, {"family": "Vellinga", "given": "Akke", "initials": "A"}, {"family": "Goossens", "given": "Herman", "initials": "H"}, {"family": "Butler", "given": "Christopher", "initials": "C"}, {"family": "van der Velden", "given": "Alike", "initials": "A"}, {"family": "Anthierens", "given": "Sibyl", "initials": "S"}, {"family": "Tonkin-Crine", "given": "Sarah", "initials": "S"}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "BJGP Open", "issn": "2398-3795", "issn-l": null}, "abstract": "The impact of the COVID-19 pandemic on patients' and clinicians' perceptions of healthcare-seeking behaviour and delivery of care is unclear. The pandemic accelerated the use of remote care and understanding its benefits and drawbacks may inform its implementation during this and future healthcare emergencies.\n\nTo explore patients' and primary care professionals' (PCPs) experiences of primary care delivery in the first wave of the pandemic.\n\nQualitative study using semi-structured interviews in primary care in eight European countries RESULTS: We conducted 146 interviews with 80 PCPs and 66 patients consulting for respiratory tract infection (RTI) symptoms, in eight European countries (England, Ireland, Belgium, the Netherlands, Greece, Poland, Sweden and Germany). Data was collected between April and July 2020 and analysed using thematic analysis. We found that patients accepted telemedicine when PCPs spent time to understand and address their concerns, but a minority preferred in-person consultations. PCPs felt that remote consultations created emotional distance between themselves and patients, and they reported having to manage diverse COVID-19-related medical and social concerns.\n\nRemote consultations for RTI symptoms may be acceptable long-term if both groups are happy to use this format but it is important that PCPs take time to address patients' concerns and provide safety-netting advice.", "doi": "10.3399/BJGPO.2021.0172", "pmid": "35031559", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "BJGPO.2021.0172"}], "notes": [], "created": "2022-01-27T08:02:44.413Z", "modified": "2022-01-27T08:02:44.450Z"}, {"entity": "publication", "iuid": "953bc095647240c7b0f72fe33901310d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/953bc095647240c7b0f72fe33901310d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/953bc095647240c7b0f72fe33901310d"}}, "title": "Mini review ATF4 and GRP78 as novel molecular targets in ER-Stress modulation for critical COVID-19 patients.", "authors": [{"family": "Shahriari-Felordi", "given": "Mahtab", "initials": "M"}, {"family": "Alikhani", "given": "Hani Keshavarz", "initials": "HK"}, {"family": "Hashemian", "given": "Seyed-Mohammad Reza", "initials": "SR"}, {"family": "Hassan", "given": "Moustapha", "initials": "M"}, {"family": "Vosough", "given": "Massoud", "initials": "M", "orcid": "0000-0001-5924-4366", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bf15c1fec524a79b8801694434587e3.json"}}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Mol Biol Rep", "issn": "1573-4978", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in more than 4.4 million deaths worldwide as of August 24, 2021. Viral infections such as SARS-CoV2 are associated with endoplasmic reticulum (ER) stress and also increased the level of reactive oxygen species. Activating transcription factor 4 (ATF4) is preferentially translated under integrated stress conditions and controls the genes involved in protein homeostasis, amino acid transport and metabolism, and also protection from oxidative stress. The GRP78, regulated either directly or indirectly by ATF4, is an essential chaperone in the ER and overexpressed and appears on the surface of almost all cells during stress and function as a SARS-CoV2 receptor. In this mini-review article, we briefly discuss the effects of SARS-CoV2 infection on the ER stress, and then the stress modulator functions of ATF4 and GRP78 as novel therapeutic targets were highlighted. Finally, the effects of GRP78 inhibitory components as potential factors for targeted therapies for COVID-19 critical cases were discussed.", "doi": "10.1007/s11033-021-07071-9", "pmid": "35028855", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11033-021-07071-9"}, {"db": "pmc", "key": "PMC8758217"}], "notes": [], "created": "2022-01-27T08:03:24.300Z", "modified": "2022-01-27T08:03:24.405Z"}, {"entity": "publication", "iuid": "804c55f24f01497f88d27d292dd8fda9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/804c55f24f01497f88d27d292dd8fda9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/804c55f24f01497f88d27d292dd8fda9"}}, "title": "Innovative vaccine approaches-a Keystone Symposia report.", "authors": [{"family": "Cable", "given": "Jennifer", "initials": "J"}, {"family": "Rappuoli", "given": "Rino", "initials": "R"}, {"family": "Klemm", "given": "Elizabeth J", "initials": "EJ"}, {"family": "Kang", "given": "Gagandeep", "initials": "G"}, {"family": "Mutreja", "given": "Ankur", "initials": "A"}, {"family": "Wright", "given": "Gavin J", "initials": "GJ"}, {"family": "Pizza", "given": "Mariagrazia", "initials": "M"}, {"family": "Castro", "given": "Sowmya Ajay", "initials": "SA"}, {"family": "Hoffmann", "given": "Joseph P", "initials": "JP"}, {"family": "Alter", "given": "Galit", "initials": "G"}, {"family": "Carfi", "given": "Andrea", "initials": "A"}, {"family": "Pollard", "given": "Andrew J", "initials": "AJ"}, {"family": "Krammer", "given": "Florian", "initials": "F"}, {"family": "Gupta", "given": "Ravindra K", "initials": "RK"}, {"family": "Wagner", "given": "Caroline E", "initials": "CE"}, {"family": "Machado", "given": "Viviane", "initials": "V"}, {"family": "Modjarrad", "given": "Kayvon", "initials": "K"}, {"family": "Corey", "given": "Lawrence", "initials": "L"}, {"family": "B Gilbert", "given": "Peter", "initials": "P"}, {"family": "Dougan", "given": "Gordon", "initials": "G"}, {"family": "Lurie", "given": "Nicole", "initials": "N"}, {"family": "Bjorkman", "given": "Pamela J", "initials": "PJ"}, {"family": "Chiu", "given": "Christopher", "initials": "C"}, {"family": "Nemes", "given": "Elisa", "initials": "E"}, {"family": "Gordon", "given": "Stephen B", "initials": "SB"}, {"family": "Steer", "given": "Andrew C", "initials": "AC"}, {"family": "Rudel", "given": "Thomas", "initials": "T"}, {"family": "Blish", "given": "Catherine A", "initials": "CA"}, {"family": "Sandberg", "given": "John Tyler", "initials": "JT"}, {"family": "Brennan", "given": "Kiva", "initials": "K"}, {"family": "Klugman", "given": "Keith P", "initials": "KP"}, {"family": "Stuart", "given": "Lynda M", "initials": "LM"}, {"family": "Madhi", "given": "Shabir A", "initials": "SA"}, {"family": "Karp", "given": "Christopher L", "initials": "CL"}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Ann N Y Acad Sci", "issn": "1749-6632", "issn-l": null}, "abstract": "The rapid development of COVID-19 vaccines was the result of decades of research to establish flexible vaccine platforms and understand pathogens with pandemic potential, as well as several novel changes to the vaccine discovery and development processes that partnered industry and governments. And while vaccines offer the potential to drastically improve global health, low-and-middle-income countries around the world often experience reduced access to vaccines and reduced vaccine efficacy. Addressing these issues will require novel vaccine approaches and platforms, deeper insight how vaccines mediate protection, and innovative trial designs and models. On June 28-30, 2021, experts in vaccine research, development, manufacturing, and deployment met virtually for the Keystone eSymposium \"Innovative Vaccine Approaches\" to discuss advances in vaccine research and development.", "doi": "10.1111/nyas.14739", "pmid": "35029310", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2022-01-27T08:03:06.543Z", "modified": "2022-01-27T08:03:06.584Z"}, {"entity": "publication", "iuid": "cd22576c59ec4b4a92e86277221098a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd22576c59ec4b4a92e86277221098a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd22576c59ec4b4a92e86277221098a9"}}, "title": "Exploring the Role of Innate Lymphocytes in the Immune System of Bats and Virus-Host Interactions.", "authors": [{"family": "Sia", "given": "Wan Rong", "initials": "WR"}, {"family": "Zheng", "given": "Yichao", "initials": "Y"}, {"family": "Han", "given": "Fei", "initials": "F"}, {"family": "Chen", "given": "Shiwei", "initials": "S"}, {"family": "Ma", "given": "Shaohua", "initials": "S"}, {"family": "Wang", "given": "Lin-Fa", "initials": "LF", "orcid": "0000-0003-2752-0535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f70fbadea6be4dc69282db33d7bfa8a5.json"}}, {"family": "Leeansyah", "given": "Edwin", "initials": "E", "orcid": "0000-0003-0505-4967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/440347079ebb4d979467290e00173eeb.json"}}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "1", "issn-l": "1999-4915"}, "abstract": "Bats are reservoirs of a large number of viruses of global public health significance, including the ancestral virus for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the causative agent of coronavirus disease 2019 (COVID-19). Although bats are natural carriers of multiple pathogenic viruses, they rarely display signs of disease. Recent insights suggest that bats have a more balanced host defense and tolerance system to viral infections that may be linked to the evolutionary adaptation to powered flight. Therefore, a deeper understanding of bat immune system may provide intervention strategies to prevent zoonotic disease transmission and to identify new therapeutic targets. Similar to other eutherian mammals, bats have both innate and adaptive immune systems that have evolved to detect and respond to invading pathogens. Bridging these two systems are innate lymphocytes, which are highly abundant within circulation and barrier tissues. These cells share the characteristics of both innate and adaptive immune cells and are poised to mount rapid effector responses. They are ideally suited as the first line of defense against early stages of viral infections. Here, we will focus on the current knowledge of innate lymphocytes in bats, their function, and their potential role in host-pathogen interactions. Moreover, given that studies into bat immune systems are often hindered by a lack of bat-specific research tools, we will discuss strategies that may aid future research in bat immunity, including the potential use of organoid models to delineate the interplay between innate lymphocytes, bat viruses, and host tolerance.", "doi": "10.3390/v14010150", "pmid": "35062356", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "v14010150"}], "notes": [], "created": "2022-01-26T10:20:02.038Z", "modified": "2022-01-26T10:20:02.135Z"}, {"entity": "publication", "iuid": "5648e9ee898a42f18e107473e4e2c5cd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5648e9ee898a42f18e107473e4e2c5cd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5648e9ee898a42f18e107473e4e2c5cd"}}, "title": "Cyberchondria, Fear of COVID-19, and Risk Perception Mediate the Association between Problematic Social Media Use and Intention to Get a COVID-19 Vaccine.", "authors": [{"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK", "orcid": "0000-0003-0530-8138", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d442447b551649d8a5372c6bf0075c91.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Chen", "given": "Hsin-Pao", "initials": "HP"}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Timpka", "given": "Toomas", "initials": "T", "orcid": "0000-0001-6049-5402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebcb4fac20f845a4bd9eaa4bf1660ebb.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "1", "issn-l": null}, "abstract": "Vaccination is the most effective way to control the COVID-19 pandemic, but vaccination hesitancy threatens this effort worldwide. Consequently, there is a need to understand what influences individuals' intention to get a COVID-19 vaccine. Restriction of information gathering on societal developments to social media may influence attitudes towards COVID-19 vaccination through exposure to disinformation and imbalanced arguments. The present study examined the association between problematic social media use and intention to get the COVID-19 vaccine, taking into account the mediating roles of cyberchondria, fear of COVID-19, and COVID-19 risk perception. In a cross-sectional survey study, a total of 10,843 residents of Qazvin City, Iran completed measures on problematic social media use, fear of COVID-19, cyberchondria, COVID-19 risk perception, and intention to get a COVID-19 vaccine. The data were analyzed using structural equation modeling (SEM). The results showed that there was no direct association between problematic social media use and intention to get a COVID-19 vaccine. Nonetheless, cyberchondria, fear of COVID-19, and COVID-19 risk perception (each or serially) mediated associations between problematic social media use and intention to get a COVID-19 vaccine. These results add to the understanding of the role of problematic social media use in COVID-19 vaccine hesitancy, i.e., it is not the quantity of social media use per se that matters. This knowledge of the mediating roles of cyberchondria, fear of COVID-19, and COVID-19 risk perception can be used by public health experts and policymakers when planning educational interventions and other initiatives in COVID-19 vaccination programs.", "doi": "10.3390/vaccines10010122", "pmid": "35062783", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "vaccines10010122"}], "notes": [], "created": "2022-01-26T10:18:52.219Z", "modified": "2022-01-26T10:18:52.299Z"}, {"entity": "publication", "iuid": "359626a625b640da95854297479aa467", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/359626a625b640da95854297479aa467.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/359626a625b640da95854297479aa467"}}, "title": "Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19.", "authors": [{"family": "Huffman", "given": "Jennifer E", "initials": "JE", "orcid": "0000-0002-9672-2491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad45db8dbb6a4829ab92daae4d5d027f.json"}}, {"family": "Butler-Laporte", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-5388-0396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/529dc69151d3463e8480b975d70fa759.json"}}, {"family": "Khan", "given": "Atlas", "initials": "A", "orcid": "0000-0002-6651-2725", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1224033b68be41e285c2aba79a4e9b41.json"}}, {"family": "Pairo-Castineira", "given": "Erola", "initials": "E"}, {"family": "Drivas", "given": "Theodore G", "initials": "TG"}, {"family": "Peloso", "given": "Gina M", "initials": "GM", "orcid": "0000-0002-5355-8636", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0baa678d09b4574b98d26876010c8e4.json"}}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T", "orcid": "0000-0001-9510-5646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd273e50091d44c3b3e8d1473ce89b0a.json"}}, {"family": "COVID-19 Host Genetics Initiative", "given": "", "initials": ""}, {"family": "Ganna", "given": "Andrea", "initials": "A"}, {"family": "Verma", "given": "Anurag", "initials": "A"}, {"family": "Baillie", "given": "J Kenneth", "initials": "JK", "orcid": "0000-0001-5258-793X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35a72da3ac10479d87eba693bbe66b4d.json"}}, {"family": "Kiryluk", "given": "Krzysztof", "initials": "K"}, {"family": "Richards", "given": "J Brent", "initials": "JB", "orcid": "0000-0002-3746-9086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8994152547ee4765b1653b834c52a21a.json"}}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ee1510080704cf6a2a6972deb94123f.json"}}], "type": "journal article", "published": "2022-01-13", "journal": {"title": "Nat Genet", "issn": "1546-1718", "issn-l": null}, "abstract": "The OAS1/2/3 cluster has been identified as a risk locus for severe COVID-19 among individuals of European ancestry, with a protective haplotype of approximately 75 kilobases (kb) derived from Neanderthals in the chromosomal region 12q24.13. This haplotype contains a splice variant of OAS1, which occurs in people of African ancestry independently of gene flow from Neanderthals. Using trans-ancestry fine-mapping approaches in 20,779 hospitalized cases, we demonstrate that this splice variant is likely to be the SNP responsible for the association at this locus, thus strongly implicating OAS1 as an effector gene influencing COVID-19 severity.", "doi": "10.1038/s41588-021-00996-8", "pmid": "35027740", "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41588-021-00996-8"}, {"db": "URL", "key": "https://doi.org/10.5281/zenodo.5708333", "description": "https://doi.org/10.5281/zenodo.5708333"}, {"db": "URL", "key": "https://www.covid19hg.org/results/r6/", "description": "https://www.covid19hg.org/results/r6/"}, {"db": "URL", "key": "https://cadd.gs.washington.edu/score", "description": "https://cadd.gs.washington.edu/score"}, {"db": "URL", "key": "https://www.internationalgenome.org/data", "description": "https://www.internationalgenome.org/data"}], "notes": [], "created": "2022-01-16T12:57:33.433Z", "modified": "2022-01-16T13:00:04.033Z"}, {"entity": "publication", "iuid": "0800ea3269874a8fae8604415ed16e3e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0800ea3269874a8fae8604415ed16e3e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0800ea3269874a8fae8604415ed16e3e"}}, "title": "Integrated epi-econ assessment of vaccination.", "authors": [{"family": "Boppart", "given": "Timo", "initials": "T"}, {"family": "Harmenberg", "given": "Karl", "initials": "K"}, {"family": "Krusell", "given": "Per", "initials": "P"}, {"family": "Olsson", "given": "Jonna", "initials": "J"}], "type": "journal article", "published": "2022-01-13", "journal": {"title": "J Econ Dyn Control", "issn": "0165-1889", "pages": "104308", "issn-l": null}, "abstract": "Using an integrated epi-econ model, we compute the value of vaccines for Covid-19, both under a planner's solution and in competitive equilibrium. The specific model, developed in Boppart, Harmenberg, Hassler, Krusell, and Olsson (2021), factors in not just value-of-life aspects along with standard economic variables but also the value of leisure activities that rely on a social component. We find that the societal value of vaccination is large; we estimate that, translated into monetary terms, the value of vaccinating one young individual in the competitive equilibrium is $17,800. Externalities are large: less than half the societal value is internalized by individuals (assuming that they act purely in their self-interest). Finally, behavioral responses are important, with a substantial share of the value of vaccines being attributed to people enjoying more socially-oriented leisure when more people are vaccinated.", "doi": "10.1016/j.jedc.2022.104308", "pmid": "35039700", "labels": {"Category: Health": null, "Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0165-1889(22)00013-6"}, {"db": "pmc", "key": "PMC8755642"}], "notes": [], "created": "2022-01-27T07:36:18.097Z", "modified": "2022-01-27T07:37:59.857Z"}, {"entity": "publication", "iuid": "445906135b7d45e1bf7d39fe5cf4dffd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/445906135b7d45e1bf7d39fe5cf4dffd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/445906135b7d45e1bf7d39fe5cf4dffd"}}, "title": "Daily uplifts during the COVID-19 pandemic: what is considered helpful in everyday life?", "authors": [{"family": "Eklund", "given": "Rakel", "initials": "R"}, {"family": "Bondjers", "given": "Kristina", "initials": "K"}, {"family": "Hensler", "given": "Ida", "initials": "I"}, {"family": "Bragesj\u00f6", "given": "Maria", "initials": "M"}, {"family": "Johannesson", "given": "Kerstin Bergh", "initials": "KB"}, {"family": "Arnberg", "given": "Filip K", "initials": "FK"}, {"family": "Sveen", "given": "Josefin", "initials": "J"}], "type": "journal article", "published": "2022-01-13", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "85", "issn-l": null}, "abstract": "Knowledge of what is uplifting and helpful during pandemics could inform the design of sustainable pandemic recommendations in the future. We have explored individuals' views on helpful and uplifting aspects of everyday life during the coronavirus disease 2019 (COVID-19) pandemic.\n\nParticipants answered a brief, daily survey via text messages during 14 consecutive days in July-August, 2020. The survey included the question: \"During the past 24 hours, is there anything that has made you feel good or helped you in your life?\" We used content analysis to compile responses from 693 participants, who provided 4,490 free-text answers, which resulted in 24 categories subsumed under 7 themes.\n\nPositive aspects during the COVID-19 pandemic primarily related to social interactions, in real life or digitally, with family, friends and others. Other important aspects concerning work, colleagues and maintaining everyday life routines. One theme concerning vacations, going on excursions and being in nature. Leisure and recreation activities, such as hobbies and physical exercise, also emerged as important, as did health-related factors. Bodily sensations, thoughts, feelings and activities that benefited well-being were mentioned frequently. Lastly, people commented on the government strategies for containing COVID-19, and whether to comply with restrictions.\n\nTo summarize, daily uplifts and helpful aspects of everyday life centered around social relationships. To comply with recommendations on physical distancing, people found creative ways to maintain social connections both digitally and face-to-face. Social interaction, maintenance of everyday life routines, hobbies and physical activity appeared to be important for well-being.", "doi": "10.1186/s12889-022-12506-4", "pmid": "35027034", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-022-12506-4"}, {"db": "pmc", "key": "PMC8757393"}], "notes": [], "created": "2022-01-27T08:14:03.975Z", "modified": "2022-01-27T08:14:03.987Z"}, {"entity": "publication", "iuid": "9043e44a6cf04e9a8a14a5d652b177b5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9043e44a6cf04e9a8a14a5d652b177b5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9043e44a6cf04e9a8a14a5d652b177b5"}}, "title": "ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFN\u03b3-driven immunopathology.", "authors": [{"family": "Gawish", "given": "Riem", "initials": "R", "orcid": "0000-0003-4267-2131", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f738be3889746db9270e409da92b2b5.json"}}, {"family": "Starkl", "given": "Philipp", "initials": "P", "orcid": "0000-0001-7521-129X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8877b7b32fe4b20b9ef859ccaff5938.json"}}, {"family": "Pimenov", "given": "Lisabeth", "initials": "L"}, {"family": "Hladik", "given": "Anastasiya", "initials": "A"}, {"family": "Lakovits", "given": "Karin", "initials": "K"}, {"family": "Oberndorfer", "given": "Felicitas", "initials": "F"}, {"family": "Cronin", "given": "Shane Jf", "initials": "SJ"}, {"family": "Ohradanova-Repic", "given": "Anna", "initials": "A", "orcid": "0000-0002-8005-8522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05059e6a105642238652352cc49b5a8b.json"}}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G"}, {"family": "Agerer", "given": "Benedikt", "initials": "B"}, {"family": "Endler", "given": "Lukas", "initials": "L"}, {"family": "Capraz", "given": "T\u00fcmay", "initials": "T"}, {"family": "Perthold", "given": "Jan W", "initials": "JW"}, {"family": "Cikes", "given": "Domagoj", "initials": "D"}, {"family": "Koglgruber", "given": "Rubina", "initials": "R"}, {"family": "Hagelkruys", "given": "Astrid", "initials": "A"}, {"family": "Montserrat", "given": "Nuria", "initials": "N"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Boon", "given": "Louis", "initials": "L"}, {"family": "Stockinger", "given": "Hannes", "initials": "H", "orcid": "0000-0001-6404-4430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/134cb6399ed043879f4f834914429698.json"}}, {"family": "Bergthaler", "given": "Andreas", "initials": "A"}, {"family": "Oostenbrink", "given": "Chris", "initials": "C", "orcid": "0000-0002-4232-2556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37566a0341cf4fd38366e43218cffd23.json"}}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}, {"family": "Knapp", "given": "Sylvia", "initials": "S", "orcid": "0000-0001-9016-5244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81c1b98b50754c84b62f7867c9dc453f.json"}}], "type": "journal article", "published": "2022-01-13", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "11", "issn-l": null}, "abstract": "Despite tremendous progress in the understanding of COVID-19, mechanistic insight into immunological, disease-driving factors remains limited. We generated maVie16, a mouse-adapted SARS-CoV-2, by serial passaging of a human isolate. In silico modeling revealed how only three Spike mutations of maVie16 enhanced interaction with murine ACE2. maVie16 induced profound pathology in BALB/c and C57BL/6 mice, and the resulting mouse COVID-19 (mCOVID-19) replicated critical aspects of human disease, including early lymphopenia, pulmonary immune cell infiltration, pneumonia, and specific adaptive immunity. Inhibition of the proinflammatory cytokines IFN\u03b3 and TNF substantially reduced immunopathology. Importantly, genetic ACE2-deficiency completely prevented mCOVID-19 development. Finally, inhalation therapy with recombinant ACE2 fully protected mice from mCOVID-19, revealing a novel and efficient treatment. Thus, we here present maVie16 as a new tool to model COVID-19 for the discovery of new therapies and show that disease severity is determined by cytokine-driven immunopathology and critically dependent on ACE2 in vivo.", "doi": "10.7554/eLife.74623", "pmid": "35023830", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8776253"}, {"db": "pii", "key": "74623"}], "notes": [], "created": "2022-01-27T08:14:33.232Z", "modified": "2023-06-19T14:37:10.312Z"}, {"entity": "publication", "iuid": "d4dabb16e6ba4d8981a4d7c5fd8d170b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4dabb16e6ba4d8981a4d7c5fd8d170b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4dabb16e6ba4d8981a4d7c5fd8d170b"}}, "title": "SARS-CoV-2 induces a durable and antigen specific humoral immunity after asymptomatic to mild COVID-19 infection", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f28f2f6ac9648629c2d2de92fe7bb59.json"}}, {"family": "Jernbom Falk", "given": "August", "initials": "A", "orcid": "0000-0002-7773-1851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40d944d7fa964f4292f10012356a2730.json"}}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/305bca9e5c6c423898c272bf06ce2f2a.json"}}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Gabrielsson", "given": "Lena", "initials": "L"}, {"family": "Salomonsson", "given": "Ann Christin", "initials": "AC"}, {"family": "Isaksson", "given": "Eva", "initials": "E", "orcid": "0000-0003-0289-8750", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30fe14f786534ff49600d0ef859d30ca.json"}}, {"family": "Rudberg", "given": "Ann Sofie", "initials": "AS"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C", "orcid": "0000-0003-0880-5375", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7394cf1c96945888fc8765568f5407c.json"}}, {"family": "Andersson", "given": "Eni", "initials": "E", "orcid": "0000-0002-5115-0637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8200b399e954f3482aec53a62df3b54.json"}}, {"family": "Olofsson", "given": "Jennie", "initials": "J"}, {"family": "Skoglund", "given": "Lovisa", "initials": "L"}, {"family": "Yousef", "given": "Jamil", "initials": "J", "orcid": "0000-0001-5915-1258", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/324e111715fc4029badd136232057025.json"}}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f2dc27d02294a15a6f691be6aab641f.json"}}, {"family": "Olausson", "given": "Mikaela", "initials": "M"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Tegel", "given": "Hanna", "initials": "H"}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "journal-article", "published": "2022-01-12", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "17", "issue": "1", "pages": "e0262169"}, "abstract": null, "doi": "10.1371/journal.pone.0262169", "pmid": "35020778", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Research Area: Drug discovery and repurposing of drugs": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-01-05T09:43:17.149Z", "modified": "2022-02-14T14:46:43.789Z"}, {"entity": "publication", "iuid": "86bede1137574ee892bfd81d8edfb49c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86bede1137574ee892bfd81d8edfb49c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86bede1137574ee892bfd81d8edfb49c"}}, "title": "Rapid cytokine release assays for analysis of SARS-CoV-2-specific T cells in whole blood.", "authors": [{"family": "T\u00f6rnell", "given": "Andreas", "initials": "A", "orcid": "0000-0003-0769-2815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0e49354b88f4f7c8792dfb4216561c8.json"}}, {"family": "Grauers Wiktorin", "given": "Hanna", "initials": "H"}, {"family": "Ringlander", "given": "Johan", "initials": "J", "orcid": "0000-0002-8483-6504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64f85af7dceb436498422e62f1a98c89.json"}}, {"family": "Arabpour", "given": "Mohammad", "initials": "M"}, {"family": "Nilsson", "given": "Malin R", "initials": "MR"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Kiffin", "given": "Roberta", "initials": "R"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K"}, {"family": "Martner", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899", "volume": null, "issue": null, "pages": null}, "abstract": "Waning of IgG antibodies against SARS-CoV-2 complicates diagnosis of past infection. Durability of T cell memory against SARS-CoV-2 remains unclear, and most current T cell protocols are unsuited for large-scale automation.\r\n\r\nWhole blood samples from 31 patients with verified past COVID-19 and 46 controls, out of which 40 received SARS-CoV-2 vaccine were stimulated with peptides spanning the nucleocapsid (NC) or spike 1 (S1) regions of SARS-CoV-2 and analyzed for interferon-\u03b3 (IFN-\u03b3) in supernatant plasma. Diagnostic accuracy of these assays was evaluated against serum anti-NC and anti-receptor-binding domain S1 IgG.\r\n\r\nInduction of IFN-\u03b3 in whole blood by NC or S1 peptides diagnosed past COVID-19 with high accuracy (AUC=0.93, AUC=0.95, respectively). In accordance with previous studies, NC-IgG levels rapidly waned with only 5/17 patients (29%) remaining seropositive >180 days after infection. By contrast, NC-peptide-induced T cell memory responses remained in 13/17 (76%) subjects >180 days after infection (P=0.012 vs. NC-IgG, McNemar test). After two vaccine doses, 18/18 donors exhibited S1-specific T cell memory.\r\n\r\nCytokine release assays for the monitoring of T cell memory in whole blood may be useful for evaluation of complications following unverified past COVID-19 and for long-term assessment of vaccine-induced T cell immunity.", "doi": "10.1093/infdis/jiac005", "pmid": "35022764", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "6504009"}], "notes": [], "created": "2022-01-13T20:54:06.771Z", "modified": "2022-01-27T08:16:10.671Z"}, {"entity": "publication", "iuid": "1ebcd2295d00429aad5aa2b70d0e4584", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ebcd2295d00429aad5aa2b70d0e4584.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ebcd2295d00429aad5aa2b70d0e4584"}}, "title": "Melflufen or pomalidomide plus dexamethasone for patients with multiple myeloma refractory to lenalidomide (OCEAN): a randomised, head-to-head, open-label, phase 3 study.", "authors": [{"family": "Schjesvold", "given": "Fredrik H", "initials": "FH"}, {"family": "Dimopoulos", "given": "Meletios-Athanasios", "initials": "MA"}, {"family": "Delimpasi", "given": "Sosana", "initials": "S"}, {"family": "Robak", "given": "Pawel", "initials": "P"}, {"family": "Coriu", "given": "Daniel", "initials": "D"}, {"family": "Legiec", "given": "Wojciech", "initials": "W"}, {"family": "Pour", "given": "Lud\u011bk", "initials": "L"}, {"family": "\u0160pi\u010dka", "given": "Ivan", "initials": "I"}, {"family": "Masszi", "given": "Tamas", "initials": "T"}, {"family": "Doronin", "given": "Vadim", "initials": "V"}, {"family": "Minarik", "given": "Jiri", "initials": "J"}, {"family": "Salogub", "given": "Galina", "initials": "G"}, {"family": "Alekseeva", "given": "Yulia", "initials": "Y"}, {"family": "Lazzaro", "given": "Antonio", "initials": "A"}, {"family": "Maisnar", "given": "Vladimir", "initials": "V"}, {"family": "Mikala", "given": "G\u00e1bor", "initials": "G"}, {"family": "Rosi\u00f1ol", "given": "Laura", "initials": "L"}, {"family": "Liberati", "given": "Anna Marina", "initials": "AM"}, {"family": "Symeonidis", "given": "Argiris", "initials": "A"}, {"family": "Moody", "given": "Victoria", "initials": "V"}, {"family": "Thuresson", "given": "Marcus", "initials": "M"}, {"family": "Byrne", "given": "Catriona", "initials": "C"}, {"family": "Harmenberg", "given": "Johan", "initials": "J"}, {"family": "Bakker", "given": "Nicolaas A", "initials": "NA"}, {"family": "H\u00e1jek", "given": "Roman", "initials": "R"}, {"family": "Mateos", "given": "Maria-Victoria", "initials": "MV"}, {"family": "Richardson", "given": "Paul G", "initials": "PG"}, {"family": "Sonneveld", "given": "Pieter", "initials": "P"}, {"family": "OCEAN (OP-103) Investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "Lancet Haematol", "issn": "2352-3026", "issn-l": null}, "abstract": "Melphalan flufenamide (melflufen), an alkylating peptide-drug conjugate, plus dexamethasone showed clinical activity and manageable safety in the phase 2 HORIZON study. We aimed to determine whether melflufen plus dexamethasone would provide a progression-free survival benefit compared with pomalidomide plus dexamethasone in patients with previously treated multiple myeloma.\n\nIn this randomised, open-label, head-to-head, phase 3 study (OCEAN), adult patients (aged \u226518 years) were recruited from 108 university hospitals, specialist hospitals, and community-based centres in 21 countries across Europe, North America, and Asia. Eligible patients had an ECOG performance status of 0-2; must have had relapsed or refractory multiple myeloma, refractory to lenalidomide (within 18 months of randomisation) and to the last line of therapy; and have received two to four previous lines of therapy (including lenalidomide and a proteasome inhibitor). Patients were randomly assigned (1:1), stratified by age, number of previous lines of therapy, and International Staging System score, to either 28-day cycles of melflufen and dexamethasone (melflufen group) or pomalidomide and dexamethasone (pomalidomide group). All patients received dexamethasone 40 mg orally on days 1, 8, 15, and 22 of each cycle. In the melflufen group, patients received melflufen 40 mg intravenously over 30 min on day 1 of each cycle and in the pomalidomide group, patients received pomalidomide 4 mg orally daily on days 1 to 21 of each cycle. The primary endpoint was progression-free survival assessed by an independent review committee in the intention-to-treat (ITT) population. Safety was assessed in patients who received at least one dose of study medication. This study is registered with ClinicalTrials.gov, NCT03151811, and is ongoing.\n\nBetween June 12, 2017, and Sept 3, 2020, 246 patients were randomly assigned to the melflufen group (median age 68 years [IQR 60-72]; 107 [43%] were female) and 249 to the pomalidomide group (median age 68 years [IQR 61-72]; 109 [44%] were female). 474 patients received at least one dose of study drug (melflufen group n=228; pomalidomide group n=246; safety population). Data cutoff was Feb 3, 2021. Median progression-free survival was 6\u00b78 months (95% CI 5\u00b70-8\u00b75; 165 [67%] of 246 patients had an event) in the melflufen group and 4\u00b79 months (4\u00b72-5\u00b77; 190 [76%] of 249 patients had an event) in the pomalidomide group (hazard ratio [HR] 0\u00b779, [95% CI 0\u00b764-0\u00b798]; p=0\u00b7032), at a median follow-up of 15\u00b75 months (IQR 9\u00b74-22\u00b78) in the melflufen group and 16\u00b73 months (10\u00b71-23\u00b72) in the pomalidomide group. Median overall survival was 19\u00b78 months (95% CI 15\u00b71-25\u00b76) at a median follow-up of 19\u00b78 months (IQR 12\u00b70-25\u00b70) in the melflufen group and 25\u00b70 months (95% CI 18\u00b71-31\u00b79) in the pomalidomide group at a median follow-up of 18\u00b76 months (IQR 11\u00b78-23\u00b77; HR 1\u00b710 [95% CI 0\u00b785-1\u00b744]; p=0\u00b747). The most common grade 3 or 4 treatment-emergent adverse events were thrombocytopenia (143 [63%] of 228 in the melflufen group vs 26 [11%] of 246 in the pomalidomide group), neutropenia (123 [54%] vs 102 [41%]), and anaemia (97 [43%] vs 44 [18%]). Serious treatment-emergent adverse events occurred in 95 (42%) patients in the melflufen group and 113 (46%) in the pomalidomide group, the most common of which were pneumonia (13 [6%] vs 21 [9%]), COVID-19 pneumonia (11 [5%] vs nine [4%]), and thrombocytopenia (nine [4%] vs three [1%]). 27 [12%] patients in the melflufen group and 32 [13%] in the pomalidomide group had fatal treatment-emergent adverse events. Fatal treatment-emergent adverse events were considered possibly treatment related in two patients in the melflufen group (one with acute myeloid leukaemia, one with pancytopenia and acute cardiac failure) and four patients in the pomalidomide group (two patients with pneumonia, one with myelodysplastic syndromes, one with COVID-19 pneumonia).\n\nMelflufen plus dexamethasone showed superior progression-free survival than pomalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma.\n\nOncopeptides AB.", "doi": "10.1016/S2352-3026(21)00381-1", "pmid": "35032434", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2352-3026(21)00381-1"}, {"db": "ClinicalTrials.gov", "key": "NCT03151811"}], "notes": [], "created": "2022-01-27T08:01:51.013Z", "modified": "2022-01-27T08:02:32.941Z"}, {"entity": "publication", "iuid": "39bc0b2add3e4b35a4e165267c32aebd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/39bc0b2add3e4b35a4e165267c32aebd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/39bc0b2add3e4b35a4e165267c32aebd"}}, "title": "Hospital Admissions for Respiratory Tract Infections in Children Aged 0-5 Years for 2017/2023.", "authors": [{"family": "Methi", "given": "Fredrik", "initials": "F"}, {"family": "St\u00f8rdal", "given": "Ketil", "initials": "K"}, {"family": "Telle", "given": "Kjetil", "initials": "K"}, {"family": "Larsen", "given": "Vilde Bergstad", "initials": "VB"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "Front Pediatr", "issn": "2296-2360", "volume": "9", "pages": "822985", "issn-l": "2296-2360"}, "abstract": "Aim: To compare hospital admissions across common respiratory tract infections (RTI) in 2017-21, and project possible hospital admissions for the RTIs among children aged 0-12 months and 1-5 years in 2022 and 2023. Methods: In 644 885 children aged 0-12 months and 1-5 years, we plotted the observed monthly number of RTI admissions [upper- and lower RTI, influenza, respiratory syncytial virus (RSV), and COVID-19] from January 1st, 2017 until October 31st, 2021. We also plotted the number of RTI admissions with a need for respiratory support. We used the observed data to project four different scenarios of RTI admissions for the rest of 2021 until 2023, with different impacts on hospital wards: (1) \"Business as usual,\" (2) \"Continuous lockdown,\" (3) \"Children's immunity debt,\" and (4) \"Maternal and child immunity debt.\" Results: By October 31st, 2021, the number of simultaneous RTI admissions had exceeded the numbers usually observed at the typical season peak in January, i.e., ~900. Based on our observed data and assuming that children and their mothers (who transfer antibodies to the very youngest) have not been exposed to RTI over the last one and a half years, our scenarios suggest that hospitals should be prepared to handle two to three times as many RTI admissions, and two to three times as many RTI admissions requiring respiratory support among 0-5-year-olds as normal, from November 2021 to April 2022. Conclusion: Scenarios with immunity debt suggest that pediatric hospital wards and policy makers should plan for extended capacity.", "doi": "10.3389/fped.2021.822985", "pmid": "35096720", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8790534"}], "notes": [], "created": "2022-02-06T16:56:19.763Z", "modified": "2022-02-06T16:56:19.769Z"}, {"entity": "publication", "iuid": "4c9b95143255486b93902708459647f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4c9b95143255486b93902708459647f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4c9b95143255486b93902708459647f0"}}, "title": "Health care utilization following \"digi-physical\" assessment compared to physical assessment for infectious symptoms in primary care.", "authors": [{"family": "Entezarjou", "given": "Artin", "initials": "A"}, {"family": "Sj\u00f6beck", "given": "Maria", "initials": "M"}, {"family": "Midl\u00f6v", "given": "Patrik", "initials": "P"}, {"family": "Nymberg", "given": "Veronica Milos", "initials": "VM"}, {"family": "Vigren", "given": "Lina", "initials": "L"}, {"family": "Labaf", "given": "Ashkan", "initials": "A"}, {"family": "Jakobsson", "given": "Ulf", "initials": "U"}, {"family": "Calling", "given": "Susanna", "initials": "S"}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "BMC Prim Care", "issn": "2731-4553", "volume": "23", "pages": "4", "issn-l": null}, "abstract": "The use of chat-based digital visits (eVisits) to assess infectious symptoms in primary care is rapidly increasing. The \"digi-physical\" model of care uses eVisits as the first line of assessment while assuming a certain proportion of patients will inevitably need to be further assessed through urgent physical examination within 48 h. It is unclear to what extent this approach can mitigate physical visits compared to assessing patients directly using office visits.\n\nThis pre-COVID-19-pandemic observational study followed up \"digi-physical\" eVisit patients (n = 1188) compared to office visit patients (n = 599) with respiratory or urinary symptoms. Index visits occurred between March 30th 2016 and March 29th 2019. The primary outcome was subsequent physical visits to physicians within two weeks using registry data from Sk\u00e5ne county, Sweden (Region Sk\u00e5nes V\u00e5rddatabas, RSVD).\n\nNo significant differences in subsequent physical visits within two weeks (excluding the first 48 h) were noted following \"digi-physical\" care compared to office visits (179 (18.0%) vs. 102 (17.6%), P = .854). As part of the \"digital-physical\" concept, a significantly larger proportion of eVisit patients had a physical visit within 48 h compared to corresponding office visit patients (191 (16.1%) vs. 19 (3.2%), P < .001), with 150 (78.5%) of these eVisit patients recommended some form of follow-up by the eVisit physician.\n\nMost eVisit patients (68.9%) with respiratory and urinary symptoms have no subsequent physical visits. Beyond an unavoidable portion of patients requiring urgent physical examination within 48 h, \"digi-physical\" management of respiratory and urinary symptoms results in comparable subsequent health care utilization compared to office visits. eVisit providers may need to optimize use of resources to minimize the proportion of patients being assessed both digitally and physically within 48 h as part of the \"digi-physical\" concept.\n\nClinicaltrials.gov identifier: NCT03474887.\n\nThe online version contains supplementary material available at 10.1186/s12875-021-01618-2.", "doi": "10.1186/s12875-021-01618-2", "pmid": "35036998", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "1618"}, {"db": "pmc", "key": "PMC8753946"}, {"db": "ClinicalTrials.gov", "key": "NCT03474887"}], "notes": [], "created": "2022-01-27T07:38:39.967Z", "modified": "2022-01-27T07:38:40.002Z"}, {"entity": "publication", "iuid": "ec5b43c5579b48b993c1bde3ea0b43f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec5b43c5579b48b993c1bde3ea0b43f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec5b43c5579b48b993c1bde3ea0b43f1"}}, "title": "Europe must come together to confront omicron.", "authors": [{"family": "Health professionals and researchers from across Europe", "given": "", "initials": ""}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "376", "pages": "o90", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.o90", "pmid": "35027352", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2022-01-27T08:04:55.333Z", "modified": "2022-01-27T08:05:01.654Z"}, {"entity": "publication", "iuid": "ece53f8821f84bd69158ea993ccbb0ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ece53f8821f84bd69158ea993ccbb0ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ece53f8821f84bd69158ea993ccbb0ff"}}, "title": "Childhood cancer survivorship care during the COVID-19 pandemic: an international report of practice implications and provider concerns.", "authors": [{"family": "van den Oever", "given": "Selina R", "initials": "SR"}, {"family": "Pluijm", "given": "Saskia M F", "initials": "SMF"}, {"family": "Skinner", "given": "Rod", "initials": "R"}, {"family": "Glaser", "given": "Adam", "initials": "A"}, {"family": "Mulder", "given": "Ren\u00e9e L", "initials": "RL"}, {"family": "Armenian", "given": "Saro", "initials": "S"}, {"family": "Bardi", "given": "Edit", "initials": "E"}, {"family": "Berger", "given": "Claire", "initials": "C"}, {"family": "Ehrhardt", "given": "Matthew J", "initials": "MJ"}, {"family": "Gilleland Marchak", "given": "Jordan", "initials": "J"}, {"family": "Haeusler", "given": "Gabrielle M", "initials": "GM"}, {"family": "Hartogh", "given": "Jaap den", "initials": "JD"}, {"family": "Hjorth", "given": "Lars", "initials": "L"}, {"family": "Kepak", "given": "Tomas", "initials": "T"}, {"family": "Kriviene", "given": "Izolda", "initials": "I"}, {"family": "Langer", "given": "Thorsten", "initials": "T"}, {"family": "Maeda", "given": "Miho", "initials": "M"}, {"family": "M\u00e1rquez-Vega", "given": "Catalina", "initials": "C"}, {"family": "Michel", "given": "Gisela", "initials": "G"}, {"family": "Muraca", "given": "Monica", "initials": "M"}, {"family": "Najib", "given": "Mohamed", "initials": "M"}, {"family": "Nathan", "given": "Paul C", "initials": "PC"}, {"family": "Panasiuk", "given": "Anna", "initials": "A"}, {"family": "Prasad", "given": "Maya", "initials": "M"}, {"family": "Roganovic", "given": "Jelena", "initials": "J"}, {"family": "Uyttebroeck", "given": "Anne", "initials": "A"}, {"family": "Winther", "given": "Jeanette F", "initials": "JF"}, {"family": "Zadravec Zaletel", "given": "Lorna", "initials": "L"}, {"family": "van Dalen", "given": "Elvira C", "initials": "EC"}, {"family": "van der Pal", "given": "Helena J H", "initials": "HJH"}, {"family": "Hudson", "given": "Melissa M", "initials": "MM"}, {"family": "Kremer", "given": "Leontien C M", "initials": "LCM"}, {"family": "IGHG COVID-19 working group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "J Cancer Surviv", "issn": "1932-2267", "issn-l": null}, "abstract": "Long-term follow-up (LTFU) care is essential to optimise health outcomes in childhood cancer survivors (CCS). We aimed to assess the impact of the COVID-19 pandemic on LTFU services and providers.\n\nA COVID-19 working group within the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) distributed a questionnaire to LTFU service providers in 37 countries across Europe, Asia, North America, Central/South America, and Australia. The questionnaire assessed how care delivery methods changed during the pandemic and respondents' level of worry about the pandemic's impact on LTFU care delivery, their finances, their health, and that of their family and friends.\n\nAmong 226 institutions, providers from 178 (79%) responded. Shortly after the initial outbreak, 42% of LTFU clinics closed. Restrictions during the pandemic resulted in fewer in-person consultations and an increased use of telemedicine, telephone, and email consultations. The use of a risk assessment to prioritise the method of LTFU consultation for individual CCS increased from 12 to 47%. While respondents anticipated in-person consultations to remain the primary method for LTFU service delivery, they expected significantly increased use of telemedicine and telephone consultations after the pandemic. On average, respondents reported highest levels of worry about psychosocial well-being of survivors.\n\nThe pandemic necessitated changes in LTFU service delivery, including greater use of virtual LTFU care and risk-stratification to identify CCS that need in-person evaluations.\n\nIncreased utilisation of virtual LTFU care and risk stratification is likely to persist post-pandemic.", "doi": "10.1007/s11764-021-01120-9", "pmid": "35020136", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11764-021-01120-9"}], "notes": [], "created": "2022-01-13T20:59:59.684Z", "modified": "2022-01-13T20:59:59.713Z"}, {"entity": "publication", "iuid": "0adb863d25c64639a287d0914a64f96c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0adb863d25c64639a287d0914a64f96c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0adb863d25c64639a287d0914a64f96c"}}, "title": "BMI in early adulthood is associated with severe COVID-19 later in life - a prospective cohort study of 1.5 million Swedish men.", "authors": [{"family": "Robertson", "given": "Josefina", "initials": "J", "orcid": "0000-0002-2167-6822", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b16ed75f7eb4950beacd818fe23d5e5.json"}}, {"family": "Adiels", "given": "Martin", "initials": "M"}, {"family": "Lissner", "given": "Lauren", "initials": "L"}, {"family": "Mehlig", "given": "Kirsten", "initials": "K"}, {"family": "Af Geijerstam", "given": "Agnes", "initials": "A"}, {"family": "Lindgren", "given": "Martin", "initials": "M"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Ekblom Bak", "given": "Elin", "initials": "E"}, {"family": "Rosengren", "given": "Annika", "initials": "A"}, {"family": "\u00c5berg", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "Obesity (Silver Spring)", "issn": "1930-739X", "issn-l": null}, "abstract": "Overweight and obesity have been identified as risk factors for severe COVID-19, however, prospective cohort studies investigating the association between overweight early in life and severity of COVID-19 are lacking.\n\nWe included 1,551,670 Swedish men, born 1950-1987, with body mass index (BMI) registered at age 18. They were followed until January 9, 2021. COVID-19 cases and comorbidities were identified through the National Patient, Intensive Care, and Cause of Death registries. Outcomes were: 1) hospitalization, 2) intensive care unit admission, and 3) death.\n\nWe found 4,315 cases (mean age 56.4 years, SD 8.8) hospitalized due to COVID-19, of which 729 were admitted to an intensive care unit, and altogether 224 deaths. The risk for hospital admission increased with higher values of BMI (kg/m2 ), despite adjustment for comorbidities, from odds ratio (OR) 1.19 (95% CI 1.08-1.31) at BMI 22.5-25 to 1.68 (1.39-2.02) at BMI \u226530 compared to BMI 18.5-20. ORs for intensive care unit admission were 1.44 (1.13-1.84) at BMI 22.5-25 and 2.61 (1.73-3.93) at BMI \u226530.\n\nHigher BMI in early adulthood was associated with severe COVID-19 many years later with a risk increase starting already at BMI \u226522.5. This underlines the necessity of preventive actions against overweight in youth to offer protection against coming viral pandemics.", "doi": "10.1002/oby.23378", "pmid": "35023305", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-01-13T20:53:28.070Z", "modified": "2022-01-27T08:15:25.788Z"}, {"entity": "publication", "iuid": "b9613c0c5cab4be28151d60193f28d1c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9613c0c5cab4be28151d60193f28d1c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9613c0c5cab4be28151d60193f28d1c"}}, "title": "A first remotely-delivered guided brief intervention to reduce intrusive memories of psychological trauma for healthcare staff working during the ongoing COVID-19 pandemic: Study protocol for a randomised controlled trial.", "authors": [{"family": "Singh", "given": "Laura", "initials": "L"}, {"family": "Kanstrup", "given": "Marie", "initials": "M"}, {"family": "Gamble", "given": "Beau", "initials": "B"}, {"family": "Geranmayeh", "given": "Anahita", "initials": "A"}, {"family": "G\u00f6ransson", "given": "Katarina E", "initials": "KE"}, {"family": "Rudman", "given": "Ann", "initials": "A"}, {"family": "Dahl", "given": "Oili", "initials": "O"}, {"family": "Lindstr\u00f6m", "given": "Veronica", "initials": "V"}, {"family": "H\u00f6rberg", "given": "Anna", "initials": "A"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}, {"family": "Moulds", "given": "Michelle L", "initials": "ML"}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "Contemp Clin Trials Commun", "issn": "2451-8654", "pages": "100884", "issn-l": null}, "abstract": "Addressing the mental health needs of healthcare staff exposed to psychologically traumatic events at work during the COVID-19 pandemic is a pressing global priority. We need to swiftly develop interventions to target the psychological consequences (e.g., persistent intrusive memories of trauma). Interventions for healthcare staff must be brief, flexible, fitted around the reality and demands of working life under the pandemic, and repeatable during ongoing/further trauma exposure. Intervention delivery during the pandemic should be remote to mitigate risk of infection; e.g., here using a blend of digitalized self-administered materials (e.g., video instructions) and guided (remote) support from a researcher. This parallel groups, two-arm, randomised controlled trial (RCT) with healthcare staff working during the COVID-19 pandemic is the first evaluation of whether a digitalized form of a brief cognitive task intervention, which is remotely-delivered (guided), reduces intrusive memories. Healthcare staff (target N = 130 completers) who experience intrusive memories of work-related traumatic event(s) during the COVID-19 pandemic (\u22652 in the week before inclusion) will be randomly allocated (1:1) to receive either the cognitive task intervention or an active (attention placebo) control, and followed up at 1-week, 1-month, 3-months, and 6-months post-intervention. The primary outcome will be the number of intrusive memories reported during Week 5; secondary and other outcomes include the number of intrusive memories reported during Week 1, and other intrusive symptoms. Findings will inform further development and dissemination of a brief cognitive task intervention to target intrusive memories.", "doi": "10.1016/j.conctc.2022.100884", "pmid": "35036626", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2451-8654(22)00001-1"}, {"db": "pmc", "key": "PMC8752164"}], "notes": [], "created": "2022-01-27T07:39:12.779Z", "modified": "2022-01-27T07:39:12.815Z"}, {"entity": "publication", "iuid": "15ab40122fc94d8b978a421f3b54face", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15ab40122fc94d8b978a421f3b54face.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15ab40122fc94d8b978a421f3b54face"}}, "title": "The local and global mental health effects of the Covid-19 pandemic.", "authors": [{"family": "Akay", "given": "Alpaslan", "initials": "A"}], "type": "journal article", "published": "2022-01-11", "journal": {"title": "Econ Hum Biol", "issn": "1873-6130", "volume": "45", "pages": "101095", "issn-l": null}, "abstract": "This paper investigates the mental health effects of the local and global level Covid-19 pandemic among the UK population. To identify the effect, we use a high-quality dataset and an original strategy where we match the previous day's confirmed pandemic cases to a four-month panel of individual mental health information observed during the interview next day. The approach suggested in this paper aims to identify the average mental health effect on the overall population for the first and second waves of the pandemic. Using a linear fixed-effects model specification, we report robust findings that the average mental health in the UK is substantially reduced by the local and global pandemic. The total reduction in the average mental health of the UK population during our sampling period (April - June, 2020) is about 1.5% for the local and 2.4% for the global cases, which sum up to a 3.9% reduction. Extrapolating the total reduction in average mental health during the first wave of the pandemic (February - September, 2020) sums up to 2.8% while the effect is as large as 9.6% for the first and second waves together, which covers roughly a year since the start. An extensive robustness check suggests that the findings are stable with respect to alternative pandemic datasets, measures, estimators, functional forms, and time functions. The characteristics of the most vulnerable individuals (e.g., elderly, chronic illness, and job security concerns) and their household conditions (e.g., living alone and no private space) are explored. The paper discusses on the implications of the results.", "doi": "10.1016/j.ehb.2021.101095", "pmid": "35092869", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1570-677X(21)00120-9"}, {"db": "pmc", "key": "PMC8750697"}], "notes": [], "created": "2022-01-31T11:40:41.594Z", "modified": "2022-02-06T17:07:27.067Z"}, {"entity": "publication", "iuid": "257c8ebf09e843069de1b8dda587e433", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/257c8ebf09e843069de1b8dda587e433.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/257c8ebf09e843069de1b8dda587e433"}}, "title": "Swallowing function in COVID-19 patients after invasive mechanical ventilation.", "authors": [{"family": "Lindh", "given": "Margareta Gonzalez", "initials": "MG"}, {"family": "Mattsson", "given": "Gustav", "initials": "G"}, {"family": "Koyi", "given": "Hirsh", "initials": "H"}, {"family": "Johansson", "given": "Monica Blom", "initials": "MB"}, {"family": "Razmi", "given": "Robin", "initials": "R"}, {"family": "Palm", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2022-01-11", "journal": {"title": "Arch Rehabil Res Clin Transl", "issn": "2590-1095", "pages": "100177", "issn-l": null}, "abstract": "To explore swallowing function and risk factors associated with delayed recovery of swallowing in COVID-19 patients post invasive mechanical ventilation using the Functional Oral Intake Scale (FOIS).\n\nLongitudinal cohort study.\n\n3 secondary-level hospitals.\n\nInvasively ventilated patients (n=28), hospitalized with severe COVID-19 who were referred to the Speech and Language Pathology (SLP) departments post mechanical ventilation between March 5 and July 5 2020 for an evaluation of swallowing function before commencing oral diet.\n\nSLP assessment, advice and therapy for dysphagia.\n\nOral intake levels at baseline and hospital discharge according to the Functional Oral Intake Scale (FOIS). Patients were stratified according to FOIS (1-5=dysphagia, 6-7= functional oral intake). Data regarding comorbidities, frailty, intubation and tracheostomy, proning and SLP evaluation were collected.\n\nDysphagia was found in 71% of the patients at baseline (in total 79% male, age 61 \u00b112 years, BMI 30 \u00b18 kg/m2). Median FOIS score at baseline was 2 (IQR 1) vs 5 (IQR 2.5) at hospital discharge. Patients with dysphagia were older (64 \u00b18.5 vs 53 \u00b116 years; p= 0.019), had a higher incidence of hypertension (70% vs 12%; p=0.006) were ventilated invasively longer (16 \u00b17 vs 10 \u00b12 days; p=0.017) or with tracheostomy (9 \u00b19 vs 1 \u00b12 days; p=0.03) longer. A negative association was found between swallowing dysfunction at bedside and days hospitalized (r=-0.471, p=0.01), and number of days at the Intensive Care Unit (ICU) (r=-0.48, p=0.01).\n\nDysphagia is prevalent in COVID-19 patients post invasive mechanical ventilation and is associated with number of days in hospital and number of days in the ICU. Swallowing function and tolerance of oral diet improved at discharge (p<0.001).", "doi": "10.1016/j.arrct.2021.100177", "pmid": "35036903", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2590-1095(21)00093-8"}, {"db": "pmc", "key": "PMC8748224"}], "notes": [], "created": "2022-01-27T07:38:50.922Z", "modified": "2022-01-27T07:38:50.958Z"}, {"entity": "publication", "iuid": "15da31ac86004e92b1ec0cb6dae07880", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15da31ac86004e92b1ec0cb6dae07880.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15da31ac86004e92b1ec0cb6dae07880"}}, "title": "Preclinical evaluation of [11C]GW457427 as a tracer for neutrophil elastase.", "authors": [{"family": "Estrada", "given": "Sergio", "initials": "S"}, {"family": "Elgland", "given": "Mathias", "initials": "M"}, {"family": "Selvaraju", "given": "Ram Kumar", "initials": "RK"}, {"family": "Mani", "given": "Kevin", "initials": "K"}, {"family": "Tegler", "given": "Gustaf", "initials": "G"}, {"family": "Wanhainen", "given": "Anders", "initials": "A"}, {"family": "W\u00e5gs\u00e4ter", "given": "Dick", "initials": "D"}, {"family": "Bergstr\u00f6m", "given": "Mats", "initials": "M"}, {"family": "Jimenez-Royo", "given": "Pilar", "initials": "P"}, {"family": "Jahan", "given": "Mahabuba", "initials": "M"}, {"family": "Nordeman", "given": "Patrik", "initials": "P"}, {"family": "Antoni", "given": "Gunnar", "initials": "G"}], "type": "journal article", "published": "2022-01-11", "journal": {"title": "Nucl Med Biol", "issn": "1872-9614", "volume": "106-107", "pages": "62-71", "issn-l": null}, "abstract": "Neutrophils are part of the innate immune system and function as a first line of defense against invading microorganisms. Overactivity of the immune system may result in a devastating immuno-inflammation with extensive damage to tissue leading to organ damage and/or failure. The literature suggests several human diseases in which neutrophil elastase (NE) is postulated to be important in the pathophysiology including inflammatory bowel disease (IBD), chronic obstructive pulmonary disorder (COPD), abdominal aortic aneurysms (AAA), breast and lung cancer, and recently also in Sars-cov-2 virus infection (Covid-19). In particular, the lungs are affected by the destructive power of the protease neutrophil elastase (NE). In this paper, we report the pre-clinical development of a selective and specific positron emission tomography (PET) tracer, [11C]GW457427, as an in vivo biomarker for the study of NE, now available for human studies.\n\n[11C]GW457427 was produced by methylation of GW447631 using [11C]methyl triflate and GMP validated production and quality control methods were developed. Chemical purity was high with no traces of the precursor GW611437 or other uv-absorbing compounds. A method for the determination of intact [11C]GW457427 in plasma was developed and the binding characteristics were evaluated in vitro and in vivo. An animal model for lung inflammation was used to investigate the specificity and sensitivity of the [11C]GW457427 tracer for neutrophil elastase (NE) in pulmonary inflammation, verified by blockade using two structurally different elastase inhibitors.\n\n[11C]GW457427 was obtained in approximately 45% radiochemical yield and with a radiochemical purity higher than 98%. Molar activity was in the range 130-360 GBq/\u03bcmol. Binding to NE was shown to be highly specific both in vitro and in vivo and a significantly higher uptake of tracer was found in a lipopolysaccharide mouse model of pulmonary inflammation compared with control animals. The uptake in lung tissue measured as standardized uptake value (SUV) strongly correlated with tissue NE content as measured by ELISA. In vitro studies also showed specific tracer binding in aortic tissue of patients with abdominal aorta aneurysm (AAA). The rate of metabolism in rats was appropriate considering the critical balance between available tracer for binding and requirement for blood clearance with about 40% and 20% intact [11C]GW457427 in plasma at 5 and 40 min, respectively. Radioactivity was cleared from blood and organs in control animals with mainly hepatobiliary excretion with distribution in the intestines and the urinary bladder; but without retention of the tracer in healthy organs of interests such as the lung, liver, kidneys or in the cardiovascular system. A dosimetry study in rat indicated that the whole-body effective dose was 2.2 \u03bcSv/MBq with bone marrow as the limiting organ. It is estimated that up to five PET-CT investigations could be performed in humans without exceeding a total dose of 10 mSv.\n\n[11C]GW457427 is a promising in vivo PET-biomarker for NE with high specific binding demonstrated both in vitro and in vivo. A GMP validated production method including quality control has been developed and a microdosing toxicity study performed with no adverse signs. [11C]GW457427 is currently being evaluated in a First-In-Man PET study.", "doi": "10.1016/j.nucmedbio.2022.01.001", "pmid": "35066391", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0969-8051(22)00001-4"}], "notes": [], "created": "2022-01-26T10:17:17.214Z", "modified": "2022-01-26T10:17:17.250Z"}, {"entity": "publication", "iuid": "ed70688f95074af8a1fea26b7f1e2959", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed70688f95074af8a1fea26b7f1e2959.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed70688f95074af8a1fea26b7f1e2959"}}, "title": "Nordic responses to covid-19 from a health promotion perspective.", "authors": [{"family": "Thualagant", "given": "Nicole", "initials": "N", "orcid": "0000-0002-5197-8979", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d68eb2cd38d64995bb48f0354726c6fd.json"}}, {"family": "Simonsen", "given": "Nina", "initials": "N", "orcid": "0000-0003-1376-7588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/862fdf76669f44b7b1ddea945c3a5953.json"}}, {"family": "Sarvim\u00e4ki", "given": "Anneli", "initials": "A"}, {"family": "Stenbock-Hult", "given": "Bettina", "initials": "B"}, {"family": "Olafsdottir", "given": "Helga S", "initials": "HS"}, {"family": "Fosse", "given": "Elisabeth", "initials": "E"}, {"family": "Torp", "given": "Steffen", "initials": "S"}, {"family": "Ringsberg", "given": "Karin C", "initials": "KC"}, {"family": "Forrinder", "given": "Ulla", "initials": "U"}, {"family": "Tillgren", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2022-01-11", "journal": {"issn": "1460-2245", "title": "Health Promot Int", "issn-l": null}, "abstract": "On 30 January 2020, the disease covid-19 was declared by the World Health Organization to be an international threat to human health and on 11 March 2020, the outbreak was declared a pandemic. The aim of this study was to analyse policy strategies developed by the five Nordic countries during the first 3 months of the pandemic from a health promotion perspective in order to identify Nordic responses to the crisis. Although the Nordic countries have a long tradition of co-operation as well as similar social welfare policies and legislation, each country developed their own strategies towards the crisis. The strategies identified were analysed from a health promotion perspective emanating from five principles: intersectorality, sustainability, equity, empowerment and a lifecourse perspective. Denmark, Finland and Norway had lockdowns to varying degrees, whereas Sweden and Iceland had no lockdowns. Iceland implemented a test and tracking strategy from the very beginning. All countries based their recommendations and restrictions on appeals to solidarity and trust in institutions and fellow citizens. The analysis showed that the strategies in all countries could be related to health promotion principles with some differences between the countries especially regarding equity and sustainability. The Nordic governments took responsibility for protecting their citizens by developing policy strategies based on restrictions and recommendations congruent with the principles of health promotion. The findings also identified issues that will pose challenges for future pandemic strategies.", "doi": "10.1093/heapro/daab211", "pmid": "35022714", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6503709"}], "notes": [], "created": "2022-01-13T20:54:40.485Z", "modified": "2022-01-27T08:16:28.127Z"}, {"entity": "publication", "iuid": "8dff9cc6d4b04c53ac781df81a4b0ac9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8dff9cc6d4b04c53ac781df81a4b0ac9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8dff9cc6d4b04c53ac781df81a4b0ac9"}}, "title": "Lessons from COVID-19 for managing transboundary climate risks and building resilience.", "authors": [{"family": "Ringsmuth", "given": "Andrew K", "initials": "AK"}, {"family": "Otto", "given": "Ilona M", "initials": "IM"}, {"family": "van den Hurk", "given": "Bart", "initials": "B"}, {"family": "Lahn", "given": "Glada", "initials": "G"}, {"family": "Reyer", "given": "Christopher P O", "initials": "CPO"}, {"family": "Carter", "given": "Timothy R", "initials": "TR"}, {"family": "Magnuszewski", "given": "Piotr", "initials": "P"}, {"family": "Monasterolo", "given": "Irene", "initials": "I"}, {"family": "Aerts", "given": "Jeroen C J H", "initials": "JCJH"}, {"family": "Benzie", "given": "Magnus", "initials": "M"}, {"family": "Campiglio", "given": "Emanuele", "initials": "E"}, {"family": "Fronzek", "given": "Stefan", "initials": "S"}, {"family": "Gaupp", "given": "Franziska", "initials": "F"}, {"family": "Jarzabek", "given": "Lukasz", "initials": "L"}, {"family": "Klein", "given": "Richard J T", "initials": "RJT"}, {"family": "Knaepen", "given": "Hanne", "initials": "H"}, {"family": "Mechler", "given": "Reinhard", "initials": "R"}, {"family": "Mysiak", "given": "Jaroslav", "initials": "J"}, {"family": "Sillmann", "given": "Jana", "initials": "J"}, {"family": "Stuparu", "given": "Dana", "initials": "D"}, {"family": "West", "given": "Chris", "initials": "C"}], "type": "journal article", "published": "2022-01-11", "journal": {"title": "Clim Risk Manag", "issn": "2212-0963", "pages": "100395", "issn-l": null}, "abstract": "COVID-19 has revealed how challenging it is to manage global, systemic and compounding crises. Like COVID-19, climate change impacts, and maladaptive responses to them, have potential to disrupt societies at multiple scales via networks of trade, finance, mobility and communication, and to impact hardest on the most vulnerable. However, these complex systems can also facilitate resilience if managed effectively. This review aims to distil lessons related to the transboundary management of systemic risks from the COVID-19 experience, to inform climate change policy and resilience building. Evidence from diverse fields is synthesised to illustrate the nature of systemic risks and our evolving understanding of resilience. We describe research methods that aim to capture systemic complexity to inform better management practices and increase resilience to crises. Finally, we recommend specific, practical actions for improving transboundary climate risk management and resilience building. These include mapping the direct, cross-border and cross-sectoral impacts of potential climate extremes, adopting adaptive risk management strategies that embrace heterogenous decision-making and uncertainty, and taking a broader approach to resilience which elevates human wellbeing, including societal and ecological resilience.", "doi": "10.1016/j.crm.2022.100395", "pmid": "35036298", "labels": {"Topics: Register-based research": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2212-0963(22)00002-X"}, {"db": "pmc", "key": "PMC8750828"}], "notes": [], "created": "2022-01-27T07:39:29.268Z", "modified": "2022-01-27T07:39:29.304Z"}, {"entity": "publication", "iuid": "2fb6bea55079411390651ca203fab727", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2fb6bea55079411390651ca203fab727.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2fb6bea55079411390651ca203fab727"}}, "title": "Fighting the COVID pandemic: national policy choices in non-pharmaceutical interventions.", "authors": [{"family": "Alfano", "given": "Vincenzo", "initials": "V"}, {"family": "Ercolano", "given": "Salvatore", "initials": "S"}, {"family": "Pinto", "given": "Mauro", "initials": "M"}], "type": "journal article", "published": "2022-01-11", "journal": {"title": "J Policy Model", "issn": "0161-8938", "issn-l": null}, "abstract": "The COVID-19 pandemic pushed countries to adopt various non-pharmaceutical interventions (NPIs). Due to the features of the pandemic, which spread over time and space, governments could decide whether or not to follow policy choices made by leaders of countries affected by the virus before them. In this study, we aim to empirically model the adoption of NPIs during the first wave of COVID-19 in the 14 European countries with more than 10 million inhabitants, in order to detect whether a policy diffusion mechanism occurred. By means of a multivariate approach based on Principal Component Analysis and Cluster Analysis, we manage to derive three clusters representing different behaviour models to which the different European countries belong in the different periods of the first wave: pre-pandemic, summer relaxation and deep-lockdown scenarios. These results bring a two-fold contribution: on the one hand, they may help us to understand differences and similarities among European countries during the first wave of the COVID-19 outbreak and guide future quantitative or qualitative studies; on the other, our findings suggest that with minor exceptions (such as Sweden and Poland), different countries adopted very similar policy strategies, which are likely to be due more to the unfolding of the pandemic than to specific governmental strategies.", "doi": "10.1016/j.jpolmod.2021.11.003", "pmid": "35034999", "labels": {"Topics: Register-based research": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0161-8938(22)00001-1"}, {"db": "pmc", "key": "PMC8750834"}], "notes": [], "created": "2022-01-27T07:40:32.473Z", "modified": "2022-01-27T07:40:32.509Z"}, {"entity": "publication", "iuid": "8c5a03884ef049498703cc650b5f7eab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c5a03884ef049498703cc650b5f7eab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c5a03884ef049498703cc650b5f7eab"}}, "title": "COVID vaccine-induced pustular psoriasis in patients with previous plaque type psoriasis.", "authors": [{"family": "Piccolo", "given": "Vincenzo", "initials": "V", "orcid": "0000-0001-7798-4368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1ddb3ce197e446dbc8156e8e3222d5e.json"}}, {"family": "Russo", "given": "Teresa", "initials": "T"}, {"family": "Mazzatenta", "given": "Carlo", "initials": "C"}, {"family": "Bassi", "given": "Andrea", "initials": "A", "orcid": "0000-0002-9157-5189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2628d4790c0041b19e8bf037d259ed99.json"}}, {"family": "Argenziano", "given": "Giuseppe", "initials": "G"}, {"family": "Cutrone", "given": "Mario", "initials": "M"}, {"family": "Danielsson Darlington", "given": "Markus", "initials": "M"}, {"family": "Grimalt", "given": "Ramon", "initials": "R"}], "type": "letter", "published": "2022-01-11", "journal": {"title": "J Eur Acad Dermatol Venereol", "issn": "1468-3083", "issn-l": null}, "abstract": null, "doi": "10.1111/jdv.17918", "pmid": "35015916", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-13T21:04:00.367Z", "modified": "2022-01-13T21:04:00.457Z"}, {"entity": "publication", "iuid": "e291a0aa78b34963944fabe6c12277b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e291a0aa78b34963944fabe6c12277b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e291a0aa78b34963944fabe6c12277b1"}}, "title": "A Global Map of COVID-19 Vaccine Acceptance Rates per Country: An Updated Concise Narrative Review.", "authors": [{"family": "Sallam", "given": "Malik", "initials": "M", "orcid": "0000-0002-0165-9670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb490d3ed32f4b76b8a39bd0320bd748.json"}}, {"family": "Al-Sanafi", "given": "Mariam", "initials": "M", "orcid": "0000-0002-1366-3693", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dd8ddbcd9bc49c486fecaa5be0bc2bf.json"}}, {"family": "Sallam", "given": "Mohammed", "initials": "M", "orcid": "0000-0003-3273-524X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d118dbd1d1b4619b46af0480b8670f2.json"}}], "type": "journal article", "published": "2022-01-11", "journal": {"title": "J Multidiscip Healthc", "issn": "1178-2390", "volume": "15", "pages": "21-45", "issn-l": null}, "abstract": "The delay or refusal of vaccination, which defines vaccine hesitancy, is a major challenge to successful control of COVID-19 epidemic. The huge number of publications addressing COVID-19 vaccine hesitancy necessitates periodic review to provide a concise summary of COVID-19 vaccine acceptance rates worldwide. In the current narrative review, data on COVID-19 vaccine acceptance rates were retrieved from surveys in 114 countries/territories. In East and Southern Africa (n = 9), the highest COVID-19 vaccine acceptance rate was reported in Ethiopia (92%), while the lowest rate was reported in Zimbabwe (50%). In West/Central Africa (n = 13), the highest rate was reported in Niger (93%), while the lowest rate was reported in Cameroon (15%). In Asia and the Pacific (n = 16), the highest rates were reported in Nepal and Vietnam (97%), while the lowest rate was reported in Hong Kong (42%). In Eastern Europe/Central Asia (n = 7), the highest rates were reported in Montenegro (69%) and Kazakhstan (64%), while the lowest rate was reported in Russia (30%). In Latin America and the Caribbean (n = 20), the highest rate was reported in Mexico (88%), while the lowest rate was reported in Haiti (43%). In the Middle East/North Africa (MENA, n = 22), the highest rate was reported in Tunisia (92%), while the lowest rate was reported in Iraq (13%). In Western/Central Europe and North America (n = 27), the highest rates were reported in Canada (91%) and Norway (89%), while the lowest rates were reported in Cyprus and Portugal (35%). COVID-19 vaccine acceptance rates \u226560% were seen in 72/114 countries/territories, compared to 42 countries/territories with rates between 13% and 59%. The phenomenon of COVID-19 vaccine hesitancy appeared more pronounced in the MENA, Europe and Central Asia, and Western/Central Africa. More studies are recommended in Africa, Eastern Europe and Central Asia to address intentions of the general public to get COVID-19 vaccination.", "doi": "10.2147/JMDH.S347669", "pmid": "35046661", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "347669"}, {"db": "pmc", "key": "PMC8760993"}], "notes": [], "created": "2022-01-27T07:03:42.486Z", "modified": "2022-01-27T07:03:42.581Z"}, {"entity": "publication", "iuid": "e03da05d0d4141368fbdd11d9def96c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e03da05d0d4141368fbdd11d9def96c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e03da05d0d4141368fbdd11d9def96c9"}}, "title": "Trials and Treatments for Vascular Brain Health: Risk Factor Modification and Cognitive Outcomes.", "authors": [{"family": "Kivipelto", "given": "Miia", "initials": "M", "orcid": "0000-0003-0992-3875", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4fcc583c88c24eb58c1a17bae81d4668.json"}}, {"family": "Palmer", "given": "Katie", "initials": "K", "orcid": "0000-0001-8783-016X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d6ec60063a647308b02d7fd8f72a1b7.json"}}, {"family": "Hoang", "given": "Tina D", "initials": "TD"}, {"family": "Yaffe", "given": "Kristine", "initials": "K", "orcid": "0000-0003-0919-3825", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/827527252aca469880c3424682107e4d.json"}}], "type": "journal article", "published": "2022-01-10", "journal": {"title": "Stroke", "issn": "1524-4628", "pages": "STROKEAHA121032614", "issn-l": null}, "abstract": "There is robust evidence linking vascular health to brain health, cognition, and dementia. In this article, we present evidence from trials of vascular risk factor treatment on cognitive outcomes. We summarize findings from randomized controlled trials of antihypertensives, lipid-lowering medications, diabetes treatments (including antidiabetic drugs versus placebo, and intensive versus standard glycemic control), and multidomain interventions (that target several domains simultaneously such as control of vascular and metabolic factors, nutrition, physical activity, and cognitive stimulation etc). We report that evidence on the efficacy of vascular risk reduction interventions is promising, but not yet conclusive, and several methodological limitations hamper interpretation. Evidence mainly comes from high-income countries and, as cognition and dementia have not been the primary outcomes of many trials, evaluation of cognitive changes have often been limited. As the cognitive aging process occurs over decades, it is unclear whether treatment during the late-life window is optimal for dementia prevention, yet older individuals have been the target of most trials thus far. Further, many trials have not been powered to explore interactions with modifiers such as age, race, and apolipoprotein E, even though sub-analyses from some trials indicate that the success of interventions differs depending on patient characteristics. Due to the complex multifactorial etiology of dementia, and variations in risk factors between individuals, multidomain interventions targeting several risk factors and mechanisms are likely to be needed and the long-term sustainability of preventive interventions will require personalized approaches that could be facilitated by digital health tools. This is especially relevant during the coronavirus disease 2019 (COVID-19) pandemic, where intervention strategies will need to be adapted to the new normal, when face-to-face engagement with participants is limited and public health measures may create changes in lifestyle that affect individuals' vascular risk profiles and subsequent risk of cognitive decline.", "doi": "10.1161/STROKEAHA.121.032614", "pmid": "35000424", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-13T21:12:39.205Z", "modified": "2022-01-13T21:12:53.206Z"}, {"entity": "publication", "iuid": "b05d09cb683c41b095a9898e26e93670", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b05d09cb683c41b095a9898e26e93670.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b05d09cb683c41b095a9898e26e93670"}}, "title": "Repurposing of Medicines in the EU: Launch of a Pilot Framework.", "authors": [{"family": "Asker-Hagelberg", "given": "Charlotte", "initials": "C"}, {"family": "Boran", "given": "Tomas", "initials": "T"}, {"family": "Bouygues", "given": "Christelle", "initials": "C"}, {"family": "Eskola", "given": "Sini Marika", "initials": "SM"}, {"family": "Helmle", "given": "Laszlo", "initials": "L"}, {"family": "Hern\u00e1ndez", "given": "C\u00e9sar", "initials": "C"}, {"family": "Hou\u00fdez", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Lee", "given": "Helen", "initials": "H"}, {"family": "Lingri", "given": "Dimitra D", "initials": "DD"}, {"family": "Louette", "given": "Laurent", "initials": "L"}, {"family": "Meheus", "given": "Lydie", "initials": "L"}, {"family": "Penninckx", "given": "Wim", "initials": "W"}, {"family": "Stepniewska", "given": "Beata", "initials": "B"}], "type": "journal article", "published": "2022-01-10", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "8", "pages": "817663", "issn-l": null}, "abstract": "Repurposing of authorised medicines has been under discussion for a long time. Drug repurposing is the process of identifying a new use for an existing medicine in an indication outside the scope of the original approved indication. Indeed, the COVID-19 health crisis has brought the concept to the frontline by proving the usefulness of this practise in favour of patients for an early access to treatment. Under the umbrella of the Pharmaceutical Committee and as a result of the discussions at the European Commission Expert Group on Safe and Timely Access to Medicines for Patients (STAMP) a virtual Repurposing Observatory Group (RepOG) was set up in 2019 to define and test the practical aspects of a pilot project thought to provide support to \"not-for-profit\" stakeholders generating or gathering data for a new therapeutic use for an authorised medicine. The group's initial plan was impacted by the outbreak of the SARS-CoV-2 pandemic and the launch of the pilot needed to be postponed. This article describes the progress and the activities conducted by the group during this past and yet extraordinary 2020-2021 to keep the project alive and explores on the background of this topic together with the obvious opportunities this health crisis has brought up in terms of repurposing of medicines.", "doi": "10.3389/fmed.2021.817663", "pmid": "35083258", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8784735"}], "notes": [], "created": "2022-01-31T11:48:41.243Z", "modified": "2022-01-31T11:48:41.256Z"}, {"entity": "publication", "iuid": "47d3fbe67a97499d8273b9ea33b939d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47d3fbe67a97499d8273b9ea33b939d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47d3fbe67a97499d8273b9ea33b939d7"}}, "title": "Heroes, victims, and villains in news media narratives about COVID-19. Analysing moralising discourse in Swedish newspaper reporting during the spring of 2020.", "authors": [{"family": "Skog", "given": "Frida", "initials": "F"}, {"family": "Lundstr\u00f6m", "given": "Ragnar", "initials": "R"}], "type": "journal article", "published": "2022-01-10", "journal": {"title": "Soc Sci Med", "issn": "1873-5347", "issn-l": null, "volume": "294", "issue": null, "pages": "114718"}, "abstract": "This paper explores news media discourse about COVID-19 during the spring of 2020 in Sweden, aiming to provide an understanding of how moralising discourse is employed in narratives about public health risks and responses. We investigate print news media content about the corona virus and COVID-19 during the early stages of the outbreak, guided analytically by framework focusing on the relationship between moral panics and moral regulation. We direct attention, first, to how both moral majorities and villains, i.e., 'folk devils', and heroes are constructed in the news. Secondly, we look at how visions for interventions are produced discursively in relation to such constructions. Our findings suggest that moralising discourse largely target risk behaviours and health care claims of middle-class groups. We also find that news media discourse about the pandemic in Sweden is marked by attacks on government interventions that are distinctly different from observations in other contexts. In conclusion, we discuss these observations in relation the political and discursive context, and the potential impact of moralising discourse on the legitimacy of public health interventions and the welfare state. Finally, we also discuss how our findings can inform theoretical discussions about political populism, moralising discourse and public health.", "doi": "10.1016/j.socscimed.2022.114718", "pmid": "35085897", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0277-9536(22)00021-1"}, {"db": "pmc", "key": "PMC8743484"}], "notes": [], "created": "2022-01-31T11:43:59.900Z", "modified": "2022-11-22T05:41:23.500Z"}, {"entity": "publication", "iuid": "2c389a8a7c8646bba44c12940f051816", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c389a8a7c8646bba44c12940f051816.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c389a8a7c8646bba44c12940f051816"}}, "title": "Effective Learning in Virtual Conferences: The Application of Five Principles of Learning.", "authors": [{"family": "Hofst\u00e4dter-Thalmann", "given": "Eva", "initials": "E"}, {"family": "Rotgans", "given": "Jerome I", "initials": "JI", "orcid": "0000-0003-4043-8261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28e7b128b0af4b228210644314f3cca2.json"}}, {"family": "Aybar Perez", "given": "Noelia", "initials": "N"}, {"family": "Nordquist", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2022-01-10", "journal": {"title": "J Eur CME", "issn": "2161-4083", "issn-l": null, "volume": "11", "issue": "1", "pages": "2019435"}, "abstract": "In this article, we examine the adaptation of learning among scientists and healthcare professionals in conferences and symposia from face-to-face to fully virtual meetings accelerated in the last years. Advantages and limitations for both settings have been described in different research studies but the effectiveness of learning can be reflected similarly by applying five fundamental principles of learning, which are based on empirical research in cognitive psychology. From a practical context, we compared the individual learning outcomes from two satellite symposia conducted face-to-face in 2019 and virtually in 2021 at the European Congress of Urology, EAU. Although both conference formats were almost identical, the five principles of learning were applied in both symposia. There were also some differences due to adaptation to online conferences, and our findings suggest that the virtual conference was perceived as significantly more effective than the face-to-face conference on all five criteria, and digital learning is a valid alternative to face-to-face conferences. What still needs to be better understood and analysed is the informal learning that is taking place during conferences, but suggesting an active design of any digital event by combining \"technical literacy\u00b7 with \"learning literacy\" will enable us to better analyse and study the impact of learning using the five learning principles in the design of other events in the future.", "doi": "10.1080/21614083.2021.2019435", "pmid": "35036048", "labels": {"Topics: Register-based research": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "2019435"}, {"db": "pmc", "key": "PMC8757606"}], "notes": [], "created": "2022-01-27T07:39:42.217Z", "modified": "2022-11-22T05:42:08.960Z"}, {"entity": "publication", "iuid": "4e9e8ed8fd3045c4b466ade89269d35e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4e9e8ed8fd3045c4b466ade89269d35e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4e9e8ed8fd3045c4b466ade89269d35e"}}, "title": "Characteristics and outcomes of COVID-19 patients with and without asthma from the United States, South Korea, and Europe.", "authors": [{"family": "Morales", "given": "Daniel", "initials": "D"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Lai", "given": "Lana", "initials": "L"}, {"family": "Sena", "given": "Anthony", "initials": "A"}, {"family": "Duvall", "given": "Scott", "initials": "S"}, {"family": "Suchard", "given": "Marc", "initials": "M"}, {"family": "Verhamme", "given": "Katia", "initials": "K", "orcid": "0000-0001-8162-4904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46ea3f9b89684f919ded6cda30a7170f.json"}}, {"family": "Rjinbeek", "given": "Peter", "initials": "P"}, {"family": "Posada", "given": "Joe", "initials": "J"}, {"family": "Ahmed", "given": "Waheed", "initials": "W"}, {"family": "Alshammary", "given": "Thamer", "initials": "T"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Blacketer", "given": "Clair", "initials": "C"}, {"family": "Burn", "given": "Ed", "initials": "E"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "You", "given": "Seng", "initials": "S"}, {"family": "Dawoud", "given": "Dalia", "initials": "D"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Gong", "given": "Menchung", "initials": "M"}, {"family": "Jonnagaddala", "given": "Jitendra", "initials": "J"}, {"family": "Lynch", "given": "Kristine", "initials": "K"}, {"family": "Matheny", "given": "Michael", "initials": "M"}, {"family": "Minty", "given": "Evan", "initials": "E"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Uribe", "given": "Albert", "initials": "A"}, {"family": "Recalde", "given": "Martina", "initials": "M"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Scheumie", "given": "Martijn", "initials": "M"}, {"family": "Shah", "given": "Karishma", "initials": "K"}, {"family": "Shah", "given": "Nigam", "initials": "N"}, {"family": "Schilling", "given": "Lisa", "initials": "L"}, {"family": "Vizcaya", "given": "David", "initials": "D"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Durate-Salles", "given": "Talita", "initials": "T"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}], "type": "journal article", "published": "2022-01-10", "journal": {"title": "J Asthma", "issn": "1532-4303", "pages": "1-14", "issn-l": null}, "abstract": "Objective: Large international comparisons describing the clinical characteristics of patients with COVID-19 are limited. The aim of the study was to perform a large-scale descriptive characterization of COVID-19 patients with asthma.Methods: We included nine databases contributing data from January-June 2020 from the US, South Korea (KR), Spain, UK and the Netherlands. We defined two cohorts of COVID-19 patients ('diagnosed' and 'hospitalized') based on COVID-19 disease codes. We followed patients from COVID-19 index date to 30 days or death. We performed descriptive analysis and reported the frequency of characteristics and outcomes in people with asthma defined by codes and prescriptions.Results: The diagnosed and hospitalized cohorts contained 666,933 and 159,552 COVID-19 patients respectively. Exacerbation in people with asthma was recorded in 1.6%-8.6% of patients at presentation. Asthma prevalence ranged from 6.2% (95%CI 5.7-6.8) to 18.5% (95%CI 18.2-18.8) in the diagnosed cohort and 5.2% (95%CI 4.0-6.8) to 20.5% (95%CI 18.6-22.6) in the hospitalized cohort. Asthma patients with COVID-19 had high prevalence of comorbidity including hypertension, heart disease, diabetes and obesity. Mortality ranged from 2.1% (95%CI 1.8-2.4) to 16.9% (95%CI 13.8-20.5) and similar or lower compared to COVID-19 patients without asthma. Acute respiratory distress syndrome occurred in 15%-30% of hospitalized COVID-19 asthma patients.Conclusion: The prevalence of asthma among COVID-19 patients varies internationally. Asthma patients with COVID-19 have high comorbidity. The prevalence of asthma exacerbation at presentation was low. Whilst mortality was similar among COVID-19 patients with and without asthma, this could be confounded by differences in clinical characteristics. Further research could help identify high-risk asthma patients.", "doi": "10.1080/02770903.2021.2025392", "pmid": "35012410", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-13T21:06:24.354Z", "modified": "2022-01-13T21:06:34.436Z"}, {"entity": "publication", "iuid": "1d45408f77254505981cbcae69859833", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d45408f77254505981cbcae69859833.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d45408f77254505981cbcae69859833"}}, "title": "COVID-19 pandemic impact on cytopathology practice in the post-lockdown period: An international, multicenter study.", "authors": [{"family": "Vigliar", "given": "Elena", "initials": "E"}, {"family": "Pisapia", "given": "Pasquale", "initials": "P", "orcid": "0000-0002-6429-0620", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/852012229c1845389cd2edf7be3bc629.json"}}, {"family": "Dello Iacovo", "given": "Filippo", "initials": "F"}, {"family": "Alcaraz-Mateos", "given": "Eduardo", "initials": "E"}, {"family": "Al\u00ec", "given": "Greta", "initials": "G"}, {"family": "Ali", "given": "Syed Z", "initials": "SZ"}, {"family": "Baloch", "given": "Zubair W", "initials": "ZW"}, {"family": "Bellevicine", "given": "Claudio", "initials": "C", "orcid": "0000-0002-7479-6457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d949e1ed72c2460a8063ee8be1bc5943.json"}}, {"family": "Bongiovanni", "given": "Massimo", "initials": "M", "orcid": "0000-0001-9846-6682", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84e33246c3844d6cb5682085e59a8401.json"}}, {"family": "Botsun", "given": "Pavlina", "initials": "P"}, {"family": "Bruzzese", "given": "Dario", "initials": "D"}, {"family": "Bubendorf", "given": "Lukas", "initials": "L", "orcid": "0000-0001-5970-1803", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00e786919dfd4d7a9ad0c5fcb93e1f10.json"}}, {"family": "B\u00fcttner", "given": "Reinhard", "initials": "R"}, {"family": "Canberk", "given": "Sule", "initials": "S", "orcid": "0000-0002-3736-1323", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26dc73d74c604ce3bab1ca1f7c55561b.json"}}, {"family": "Capitanio", "given": "Arrigo", "initials": "A"}, {"family": "Casadio", "given": "Chiara", "initials": "C"}, {"family": "Cazacu", "given": "Eugeniu", "initials": "E"}, {"family": "Cochand-Priollet", "given": "Beatrix", "initials": "B"}, {"family": "D'Amuri", "given": "Alessandro", "initials": "A"}, {"family": "Davis", "given": "Katelynn", "initials": "K"}, {"family": "Eloy", "given": "Catarina", "initials": "C", "orcid": "0000-0001-7642-1280", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf436dea894e4c7fa1c499b83d218f39.json"}}, {"family": "Engels", "given": "Marianne", "initials": "M"}, {"family": "Fadda", "given": "Guido", "initials": "G"}, {"family": "Fontanini", "given": "Gabriella", "initials": "G"}, {"family": "Fulciniti", "given": "Franco", "initials": "F"}, {"family": "Hofman", "given": "Paul", "initials": "P", "orcid": "0000-0003-0431-9353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80753da68c474a46a5fd85c76e468fdb.json"}}, {"family": "Iaccarino", "given": "Antonino", "initials": "A"}, {"family": "Ieni", "given": "Antonio", "initials": "A"}, {"family": "Jiang", "given": "Xiaoyin Sara", "initials": "XS", "orcid": "0000-0002-3069-3130", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5826f5fd5af4a84ac308e9368fbcad9.json"}}, {"family": "Kakudo", "given": "Kennichi", "initials": "K", "orcid": "0000-0002-0347-7264", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2cbc47cb73124e98ac7d540b562f0b97.json"}}, {"family": "Kern", "given": "Izidor", "initials": "I"}, {"family": "Kholova", "given": "Ivana", "initials": "I"}, {"family": "Linton McDermott", "given": "Kathryn M", "initials": "KM"}, {"family": "Liu", "given": "Chinhua", "initials": "C"}, {"family": "Lobo", "given": "Anandi", "initials": "A"}, {"family": "Lozano", "given": "Maria D", "initials": "MD", "orcid": "0000-0002-6796-9380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54800a1ac917410c9cfa7ab5f3b22bc2.json"}}, {"family": "Malapelle", "given": "Umberto", "initials": "U"}, {"family": "Maleki", "given": "Zahra", "initials": "Z", "orcid": "0000-0003-3273-4802", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31b3a0890ae1476abfa8eb1bfd8df3ee.json"}}, {"family": "Michelow", "given": "Pamela", "initials": "P"}, {"family": "Mikula", "given": "Michael W", "initials": "MW"}, {"family": "Musayev", "given": "Jamal", "initials": "J"}, {"family": "\u00d6zg\u00fcn", "given": "Gonca", "initials": "G"}, {"family": "Oznur", "given": "Meltem", "initials": "M"}, {"family": "Peir\u00f3 Marqu\u00e9s", "given": "Francisca Maria", "initials": "FM"}, {"family": "Poller", "given": "David", "initials": "D"}, {"family": "Pyzlak", "given": "Michal", "initials": "M"}, {"family": "Robinson", "given": "Betsy", "initials": "B"}, {"family": "Rossi", "given": "Esther Diana", "initials": "ED", "orcid": "0000-0003-3819-4229", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/353c4e390a6646f0a52cd11d0ec6aeb7.json"}}, {"family": "Roy-Chowdhuri", "given": "Sinchita", "initials": "S", "orcid": "0000-0002-9447-7701", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ca8b8486db4f45eebd213b3d4770fa0f.json"}}, {"family": "Saieg", "given": "Mauro", "initials": "M", "orcid": "0000-0002-9438-226X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/921ab9772dbb44e69e06da15d306ca48.json"}}, {"family": "Savic Prince", "given": "Spasenija", "initials": "S"}, {"family": "Schmitt", "given": "Fernando C", "initials": "FC"}, {"family": "Segu\u00ed Iv\u00e1\u00f1ez", "given": "Francisco Javier", "initials": "FJ"}, {"family": "\u0160toos-Vei\u0107", "given": "Tajana", "initials": "T"}, {"family": "Sulaieva", "given": "Oksana", "initials": "O"}, {"family": "Sweeney", "given": "Brenda J", "initials": "BJ"}, {"family": "Tuccari", "given": "Giovanni", "initials": "G"}, {"family": "van Velthuysen", "given": "Marie-Louise", "initials": "ML"}, {"family": "VanderLaan", "given": "Paul A", "initials": "PA", "orcid": "0000-0002-7234-5652", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d17424496a6b41efbc5d6fba770344a8.json"}}, {"family": "Vielh", "given": "Philippe", "initials": "P"}, {"family": "Viola", "given": "Patrizia", "initials": "P"}, {"family": "Voorham", "given": "Quirinus J M", "initials": "QJM"}, {"family": "Weynand", "given": "Birgit", "initials": "B"}, {"family": "Zeppa", "given": "Pio", "initials": "P", "orcid": "0000-0001-7358-5925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9687953aaff245c8aa33b11d17655cbf.json"}}, {"family": "Faquin", "given": "William C", "initials": "WC", "orcid": "0000-0002-9043-7171", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf42ad6f77864413a0a1d273f6a6c977.json"}}, {"family": "Pitman", "given": "Martha Bishop", "initials": "MB"}, {"family": "Troncone", "given": "Giancarlo", "initials": "G", "orcid": "0000-0003-1630-5805", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a12ba1f7a12141b6b95e6e715b12e9db.json"}}], "type": "journal article", "published": "2022-01-10", "journal": {"title": "Cancer Cytopathol", "issn": "1934-6638", "issn-l": null}, "abstract": "In a previous worldwide survey, the authors showed a drastic reduction in the number of cytological specimens processed during the coronavirus disease 2019 \"lockdown\" period along with an increase in malignancy rates. To assess the continued impact of the pandemic on cytological practices around the world, they undertook a second follow-up worldwide survey collecting data from the post-lockdown period (2020).\n\nParticipants were asked to provide data regarding their cytopathology activity during the first 12 weeks of their respective national post-lockdown period (2020), which ranged from April 4 to October 31. Differences between the post-lockdown period and the corresponding 2019 period were evaluated, and the authors specifically focused on rates of malignant diagnoses.\n\nA total of 29 respondents from 17 countries worldwide joined the survey. Overall, a lower number of cytological specimens (n = 236,352) were processed in comparison with the same period in 2019 (n = 321,466) for a relative reduction of 26.5%. The overall malignancy rate showed a statistically significant increase (12,442 [5.26%] vs 12,882 [4.01%]; P < .001) during the same time period. Similar results were obtained if both malignancy and suspicious for malignancy rates were considered together (15,759 [6.58%] vs 16,011 [4.98%]; P < .001).\n\nThe data showed a persistent reduction in the cytological specimen volume during the post-lockdown period (2020). However, the relative increase in the cytological workload in the late part of the post-lockdown is a promising finding of a slow return to normality.", "doi": "10.1002/cncy.22547", "pmid": "35006650", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-13T21:09:27.944Z", "modified": "2022-01-13T21:09:28.530Z"}, {"entity": "publication", "iuid": "0e7c6e43fa9549238ec093d52cb77749", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e7c6e43fa9549238ec093d52cb77749.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e7c6e43fa9549238ec093d52cb77749"}}, "title": "A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo.", "authors": [{"family": "Hanke", "given": "Leo", "initials": "L", "orcid": "0000-0001-5514-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a35f10de4f2e4aee98278f6ab845613d.json"}}, {"family": "Das", "given": "Hrishikesh", "initials": "H", "orcid": "0000-0001-7495-7065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/496d4befba454f3f85e23ddd413ada9c.json"}}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Perez Vidakovics", "given": "Laura", "initials": "L", "orcid": "0000-0003-4283-812X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b85cf54481e94b8c95f2bf8db1038395.json"}}, {"family": "Urgard", "given": "Egon", "initials": "E"}, {"family": "Moliner-Morro", "given": "Ainhoa", "initials": "A"}, {"family": "Kim", "given": "Changil", "initials": "C", "orcid": "0000-0003-4977-4384", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d36347170c34ca386deee72faccc534.json"}}, {"family": "Karl", "given": "Vivien", "initials": "V"}, {"family": "Pankow", "given": "Alec", "initials": "A"}, {"family": "Smith", "given": "Natalie L", "initials": "NL"}, {"family": "Porebski", "given": "Bartlomiej", "initials": "B"}, {"family": "Fernandez-Capetillo", "given": "Oscar", "initials": "O"}, {"family": "Sezgin", "given": "Erdinc", "initials": "E", "orcid": "0000-0002-4915-388X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30c3688527ac4caf8d07426703ace615.json"}}, {"family": "Pedersen", "given": "Gabriel K", "initials": "GK"}, {"family": "Coquet", "given": "Jonathan M", "initials": "JM", "orcid": "0000-0002-5967-4857", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ca3e4664dc444a3a992531ad3dd9201.json"}}, {"family": "H\u00e4llberg", "given": "B Martin", "initials": "BM", "orcid": "0000-0002-6781-0345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea241fd233ca40a6be4ffa1472d2aa06.json"}}, {"family": "Murrell", "given": "Ben", "initials": "B", "orcid": "0000-0002-0393-4445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60dac9ecf84d4eb3b90fb4ee1298bc52.json"}}, {"family": "McInerney", "given": "Gerald M", "initials": "GM", "orcid": "0000-0003-2257-7241", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7770437d845444a8a07865bf5b62fab0.json"}}], "type": "journal article", "published": "2022-01-10", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "13", "issue": "1", "pages": "155"}, "abstract": "Antibodies binding to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike have therapeutic promise, but emerging variants show the potential for virus escape. This emphasizes the need for therapeutic molecules with distinct and novel neutralization mechanisms. Here we describe the isolation of a nanobody that interacts simultaneously with two RBDs from different spike trimers of SARS-CoV-2, rapidly inducing the formation of spike trimer-dimers leading to the loss of their ability to attach to the host cell receptor, ACE2. We show that this nanobody potently neutralizes SARS-CoV-2, including the beta and delta variants, and cross-neutralizes SARS-CoV. Furthermore, we demonstrate the therapeutic potential of the nanobody against SARS-CoV-2 and the beta variant in a human ACE2 transgenic mouse model. This naturally elicited bispecific monomeric nanobody establishes an uncommon strategy for potent inactivation of viral antigens and represents a promising antiviral against emerging SARS-CoV-2 variants.", "doi": "10.1038/s41467-021-27610-z", "pmid": "35013189", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Funder: H2020": null, "Research Area: Drug discovery and repurposing of drugs": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC8748511"}, {"db": "URL", "key": "https://www.ebi.ac.uk/emdb/EMD-12465", "description": "https://www.ebi.ac.uk/emdb/EMD-12465"}, {"db": "URL", "key": "https://www.ebi.ac.uk/emdb/EMD-12461", "description": "https://www.ebi.ac.uk/emdb/EMD-12461"}], "notes": [], "created": "2022-01-11T06:56:36.794Z", "modified": "2022-02-17T08:51:26.108Z"}, {"entity": "publication", "iuid": "4f962a14f58b4d73ae2463bc11156c41", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4f962a14f58b4d73ae2463bc11156c41.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4f962a14f58b4d73ae2463bc11156c41"}}, "title": "Premature mortality attributable to COVID-19: potential years of life lost in 17 countries around the world, January-August 2020.", "authors": [{"family": "Ugarte", "given": "Maider Pagola", "initials": "MP"}, {"family": "Achilleos", "given": "Souzana", "initials": "S", "orcid": "0000-0002-1688-9225", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce5b51f054484805abea56ebad2bffc6.json"}}, {"family": "Quattrocchi", "given": "Annalisa", "initials": "A"}, {"family": "Gabel", "given": "John", "initials": "J"}, {"family": "Kolokotroni", "given": "Ourania", "initials": "O"}, {"family": "Constantinou", "given": "Constantina", "initials": "C"}, {"family": "Nicolaou", "given": "Nicoletta", "initials": "N"}, {"family": "Rodriguez-Llanes", "given": "Jose Manuel", "initials": "JM"}, {"family": "Huang", "given": "Qian", "initials": "Q"}, {"family": "Verstiuk", "given": "Olesia", "initials": "O"}, {"family": "Pidmurniak", "given": "Nataliia", "initials": "N"}, {"family": "Tao", "given": "Jennifer Wenjing", "initials": "JW"}, {"family": "Burstr\u00f6m", "given": "Bo", "initials": "B"}, {"family": "Klepac", "given": "Petra", "initials": "P"}, {"family": "Erzen", "given": "Ivan", "initials": "I"}, {"family": "Chong", "given": "Mario", "initials": "M"}, {"family": "Barron", "given": "Manuel", "initials": "M"}, {"family": "Hagen", "given": "Terje P", "initials": "TP"}, {"family": "Kalmatayeva", "given": "Zhanna", "initials": "Z"}, {"family": "Davletov", "given": "Kairat", "initials": "K"}, {"family": "Zucker", "given": "Inbar", "initials": "I"}, {"family": "Kaufman", "given": "Zalman", "initials": "Z"}, {"family": "Kereselidze", "given": "Maia", "initials": "M"}, {"family": "Kandelaki", "given": "Levan", "initials": "L"}, {"family": "Le Meur", "given": "Nolwenn", "initials": "N"}, {"family": "Goldsmith", "given": "Lucy", "initials": "L"}, {"family": "Critchley", "given": "Julia A", "initials": "JA"}, {"family": "Pinilla", "given": "Maria Angelica", "initials": "MA"}, {"family": "Jaramillo", "given": "Gloria Isabel", "initials": "GI"}, {"family": "Teixeira", "given": "Domingos", "initials": "D"}, {"family": "Gom\u00e9z", "given": "Lara Ferrero", "initials": "LF"}, {"family": "Lobato", "given": "Jackeline", "initials": "J"}, {"family": "Ara\u00fajo", "given": "Carolina", "initials": "C"}, {"family": "Cuthbertson", "given": "Joseph", "initials": "J"}, {"family": "Bennett", "given": "Catherine M", "initials": "CM"}, {"family": "Polemitis", "given": "Antonis", "initials": "A"}, {"family": "Charalambous", "given": "Andreas", "initials": "A"}, {"family": "Demetriou", "given": "Christiana A", "initials": "CA"}, {"family": "C-MOR consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2022-01-09", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "54", "issn-l": null}, "abstract": "Understanding the impact of the burden of COVID-19 is key to successfully navigating the COVID-19 pandemic. As part of a larger investigation on COVID-19 mortality impact, this study aims to estimate the Potential Years of Life Lost (PYLL) in 17 countries and territories across the world (Australia, Brazil, Cape Verde, Colombia, Cyprus, France, Georgia, Israel, Kazakhstan, Peru, Norway, England & Wales, Scotland, Slovenia, Sweden, Ukraine, and the United States [USA]).\n\nAge- and sex-specific COVID-19 death numbers from primary national sources were collected by an international research consortium. The study period was established based on the availability of data from the inception of the pandemic to the end of August 2020. The PYLL for each country were computed using 80 years as the maximum life expectancy.\n\nAs of August 2020, 442,677 (range: 18-185,083) deaths attributed to COVID-19 were recorded in 17 countries which translated to 4,210,654 (range: 112-1,554,225) PYLL. The average PYLL per death was 8.7 years, with substantial variation ranging from 2.7 years in Australia to 19.3 PYLL in Ukraine. North and South American countries as well as England & Wales, Scotland and Sweden experienced the highest PYLL per 100,000 population; whereas Australia, Slovenia and Georgia experienced the lowest. Overall, males experienced higher PYLL rate and higher PYLL per death than females. In most countries, most of the PYLL were observed for people aged over 60 or 65 years, irrespective of sex. Yet, Brazil, Cape Verde, Colombia, Israel, Peru, Scotland, Ukraine, and the USA concentrated most PYLL in younger age groups.\n\nOur results highlight the role of PYLL as a tool to understand the impact of COVID-19 on demographic groups within and across countries, guiding preventive measures to protect these groups under the ongoing pandemic. Continuous monitoring of PYLL is therefore needed to better understand the burden of COVID-19 in terms of premature mortality.", "doi": "10.1186/s12889-021-12377-1", "pmid": "35000578", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-12377-1"}], "notes": [], "created": "2022-01-13T21:12:19.822Z", "modified": "2022-01-13T21:12:19.852Z"}, {"entity": "publication", "iuid": "5a5acc90669347b880b44b80f950c5b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5a5acc90669347b880b44b80f950c5b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5a5acc90669347b880b44b80f950c5b3"}}, "title": "Occupation and COVID-19 diagnosis, hospitalisation and ICU admission among foreign-born and Swedish-born employees: a register-based study.", "authors": [{"family": "Nwaru", "given": "Chioma Adanma", "initials": "CA", "orcid": "0000-0002-1772-2347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/901880ae4f9143cc96fedf11aa673bc7.json"}}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Franz\u00e9n", "given": "Stefan", "initials": "S"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}], "type": "journal article", "published": "2022-01-07", "journal": {"title": "J Epidemiol Community Health", "issn": "1470-2738", "issn-l": null}, "abstract": "Research on occupation and risk of COVID-19 among foreign-born workers is lacking. We investigated whether working in essential occupations was associated with COVID-19 diagnosis, hospitalisation and intensive care unit (ICU) admission and whether foreign-born workers in similar occupations as Swedish-born individuals had a higher risk of the studied outcomes.\n\nOccupational data (2018-2019) of 326 052 employees (20-65 years) who were resident in Sweden as of 1 January 2020 were linked to COVID-19 data registered from 1 January 2020 to 28 February 2021. We analysed the risk of COVID-19 outcomes in different occupational groups and in four immigrant/occupation intersectional groups using Cox proportional hazards regression with adjustments for sociodemographic and socioeconomic characteristics and pre-existing comorbidities.\n\nWe identified 29797, 1069 and 152 cases of COVID-19 diagnosis, hospitalisations and ICU admissions, respectively, in our cohort. Workers in essential occupations had an elevated risk of COVID-19 diagnosis, hospitalisation, and ICU admissions. Healthcare workers had a higher risk of all the outcomes compared with other essential workers. Relative to Swedish-born workers in non-essential occupations, foreign-born workers in essential occupations had 1.85 (95% CI 1.78 to 1.93), 3.80 (95% CI 3.17 to 4.55) and 3.79 (95% CI 2.33 to 6.14) times higher risk of COVID-19 diagnosis, hospitalisation and ICU admission, respectively. The corresponding risks among Swedish-born workers in essential occupations were 1.44 (95% CI 1.40 to 1.49), 1.30 (95% CI 1.08 to 1.56) and 1.46 (95% CI 0.90 to 2.38).\n\nOccupation was associated with COVID-19 outcomes and contributed to the burden of COVID-19 among foreign-born individuals in this study.", "doi": "10.1136/jech-2021-218278", "pmid": "34996808", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "jech-2021-218278"}], "notes": [], "created": "2022-01-10T15:29:08.356Z", "modified": "2022-01-10T15:29:08.430Z"}, {"entity": "publication", "iuid": "52e1e554737e44d5996fffab9096eb18", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/52e1e554737e44d5996fffab9096eb18.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/52e1e554737e44d5996fffab9096eb18"}}, "title": "Immunity to SARS-CoV-2 up to 15 months after infection.", "authors": [{"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Piralla", "given": "Antonio", "initials": "A"}, {"family": "Zuo", "given": "Fanglei", "initials": "F"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Cassaniti", "given": "Irene", "initials": "I"}, {"family": "Wan", "given": "Hui", "initials": "H"}, {"family": "Kumagai-Braesh", "given": "Makiko", "initials": "M"}, {"family": "Andr\u00e9ll", "given": "Juni", "initials": "J"}, {"family": "Percivalle", "given": "Elena", "initials": "E"}, {"family": "Sammartino", "given": "Jos\u00e8 Camilla", "initials": "JC"}, {"family": "Wang", "given": "Yating", "initials": "Y"}, {"family": "Vlachiotis", "given": "Stelios", "initials": "S"}, {"family": "Attevall", "given": "Janine", "initials": "J"}, {"family": "Bergami", "given": "Federica", "initials": "F"}, {"family": "Ferrari", "given": "Alessandro", "initials": "A"}, {"family": "Colaneri", "given": "Marta", "initials": "M"}, {"family": "Vecchia", "given": "Marco", "initials": "M"}, {"family": "Sambo", "given": "Margherita", "initials": "M"}, {"family": "Zuccaro", "given": "Valentina", "initials": "V"}, {"family": "Asperges", "given": "Erika", "initials": "E"}, {"family": "Bruno", "given": "Raffaele", "initials": "R"}, {"family": "Oggionni", "given": "Tiberio", "initials": "T"}, {"family": "Meloni", "given": "Federica", "initials": "F"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Bertoglio", "given": "Federico", "initials": "F"}, {"family": "Schubert", "given": "Maren", "initials": "M"}, {"family": "Calzolai", "given": "Luigi", "initials": "L"}, {"family": "Varani", "given": "Luca", "initials": "L"}, {"family": "Hust", "given": "Michael", "initials": "M"}, {"family": "Xue", "given": "Yintong", "initials": "Y"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}], "type": "journal article", "published": "2022-01-07", "journal": {"title": "iScience", "issn": "2589-0042", "pages": "103743", "issn-l": "2589-0042"}, "abstract": "Information concerning the longevity of immunity to SARS-CoV-2 following natural infection may have considerable implications for durability of immunity induced by vaccines. Here, we monitored the SARS-CoV-2 specific immune response in COVID-19 patients followed up to 15 months after symptoms onset. Following a peak at day 15-28 post-infection, the IgG antibody response and plasma neutralizing titers gradually decreased over time but stabilized after 6 months. Compared to G614, plasma neutralizing titers were more than 8-fold lower against variants Beta, Gamma and Delta. SARS-CoV-2-specific memory B and T cells persisted in the majority of patients up to 15 months although a significant decrease in specific T cells, but not B cells, was observed between 6 and 15 months. The antiviral specific immunity especially memory B cells in COVID-19 convalescent patients is long-lasting, but some variants of concern may at least partially escape the neutralizing activity of plasma antibodies.", "doi": "10.1016/j.isci.2022.103743", "pmid": "35018336", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(22)00013-X"}, {"db": "pmc", "key": "PMC8736281"}], "notes": [], "created": "2022-01-13T20:59:32.521Z", "modified": "2022-01-13T20:59:32.535Z"}, {"entity": "publication", "iuid": "2fa81706e5ad425182dc27b9e57922ac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2fa81706e5ad425182dc27b9e57922ac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2fa81706e5ad425182dc27b9e57922ac"}}, "title": "COVID-19 related outcomes among individuals with neurodegenerative diseases: a cohort analysis in the UK biobank.", "authors": [{"family": "Hu", "given": "Yihan", "initials": "Y"}, {"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Hou", "given": "Can", "initials": "C"}, {"family": "Chen", "given": "Wenwen", "initials": "W"}, {"family": "Zhang", "given": "Hanyue", "initials": "H"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Sun", "given": "Yajing", "initials": "Y"}, {"family": "Qu", "given": "Yuanyuan", "initials": "Y"}, {"family": "Feychting", "given": "Maria", "initials": "M"}, {"family": "Valdimarsdottir", "given": "Unnur", "initials": "U"}, {"family": "Song", "given": "Huan", "initials": "H", "orcid": "0000-0003-3845-8079", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2e35902226b407487330fc6c7368759.json"}}, {"family": "Fang", "given": "Fang", "initials": "F"}], "type": "journal article", "published": "2022-01-07", "journal": {"title": "BMC Neurol", "issn": "1471-2377", "volume": "22", "issue": "1", "pages": "15", "issn-l": null}, "abstract": "An increased susceptibility to COVID-19 has been suggested for individuals with neurodegenerative diseases, but data are scarce from longitudinal studies.\n\nIn this community-based cohort study, we included 96,275 participants of the UK Biobank who had available SARS-CoV-2 test results in Public Health England. Of these, 2617 had a clinical diagnosis of neurodegenerative diseases in the UK Biobank inpatient hospital data before the outbreak of COVID-19 (defined as January 31st, 2020), while the remaining participants constituted the reference group. We then followed both groups from January 31st, 2020 to June 14th, 2021 for ascertainment of COVID-19 outcomes, including any COVID-19, inpatient care for COVID-19, and COVID-19 related death. Logistic regression was applied to estimate the association between neurogenerative disease and risks of COVID-19 outcomes, adjusted for multiple confounders and somatic comorbidities.\n\nWe observed an elevated risk of COVID-19 outcomes among individuals with a neurodegenerative disease compared with the reference group, corresponding to a fully adjusted odds ratio of 2.47 (95%CI 2.25-2.71) for any COVID-19, 2.18 (95%CI 1.94-2.45) for inpatient COVID-19, and 3.67 (95%CI 3.11-4.34) for COVID-19 related death. Among individuals with a positive test result for SARS-CoV-2, individuals with neurodegenerative diseases had also a higher risk of COVID-19 related death than others (fully adjusted odds ratio 2.08; 95%CI 1.71-2.53).\n\nAmong UK Biobank participants who received at least one test for SARS-CoV-2, a pre-existing diagnosis of neurodegenerative disease was associated with a subsequently increased risk of COVID-19, especially COVID-19 related death.", "doi": "10.1186/s12883-021-02536-7", "pmid": "34996388", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8739517"}, {"db": "pii", "key": "10.1186/s12883-021-02536-7"}], "notes": [], "created": "2022-01-10T15:30:44.904Z", "modified": "2023-06-19T14:48:12.016Z"}, {"entity": "publication", "iuid": "57157113a28045798857617d872a36db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/57157113a28045798857617d872a36db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/57157113a28045798857617d872a36db"}}, "title": "COVID-19 collateral damage-psychological burden and behavioural changes among older adults during the first outbreak in Stockholm, Sweden: a cross-sectional study.", "authors": [{"family": "Beridze", "given": "Giorgi", "initials": "G", "orcid": "0000-0002-2615-226X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0a1b88868e743d180580c5545dc3b3f.json"}}, {"family": "Triolo", "given": "Federico", "initials": "F"}, {"family": "Grande", "given": "Giulia", "initials": "G"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A", "orcid": "0000-0001-9064-9222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/166407b0da5346b3aef841949b0212da.json"}}], "type": "journal article", "published": "2022-01-07", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "1", "pages": "e058422", "issn-l": "2044-6055"}, "abstract": "To explore the indirect negative effects of COVID-19 restrictions (collateral damage) on the lives and health of older adults living in central Stockholm, and to characterise the sociodemographic profile of those with the highest susceptibility to this damage.\n\nCross-sectional study.\n\nDistrict of Kungsholmen in Stockholm, Sweden.\n\nOlder adults aged 68 years and above (n=1231) who participated in the ad hoc COVID-19-related phone questionnaire administered by trained staff between May and June 2020 and who had previously attended the regular follow-up assessment of the Swedish National study on Aging and Care in Kungsholmen (SNAC-K) during 2016-2019.\n\nThree dimensions of collateral damage: psychological burden (feelings of worry, stress and loneliness), reductions in social and physical activities, and reductions in medical and social care use since the beginning of the pandemic. Logistic regression models were used to test the association between age, sex, education and living arrangement, and the risk of collateral damage.\n\nVast majority of participants adhered to the national public health recommendations, with over three-quarters practising self-isolation (n=928). Half of the sample reported psychological burden, 55.3% reported reductions in social or physical activity, and 11.3% reported decreased medical or social care use. Over three quarters of participants (77.8%) were affected by at least one of the three collateral damage dimensions. Female sex was the strongest sociodemographic predictor of both individual and co-occurring dimensions of collateral damage.\n\nCOVID-19 and its restrictions during the first half of 2020 had a negative effect on the health and lives of a majority of the elderly living in central Stockholm. Women were at a higher risk of these negative consequences. We emphasise the need for predefined, evidence-based interventions to support those who are most susceptible to these consequences, both during the pandemic and once the outbreak is overcome.", "doi": "10.1136/bmjopen-2021-058422", "pmid": "34996805", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-058422"}], "notes": [], "created": "2022-01-10T15:29:48.426Z", "modified": "2022-01-10T15:29:48.506Z"}, {"entity": "publication", "iuid": "11d995e1fa8945db86dd93e86bc0fe4a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/11d995e1fa8945db86dd93e86bc0fe4a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/11d995e1fa8945db86dd93e86bc0fe4a"}}, "title": "What Do Physicians Think About the Use of Telemedicine to Recruit and Assess Participants in mHealth-Related Clinical Studies as a Consequence of the COVID-19 Pandemic?", "authors": [{"family": "Pereira", "given": "Ana Margarida", "initials": "AM", "orcid": "0000-0002-5468-0932", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8bb795e913654a9d80a82086f074f65c.json"}}, {"family": "Almeida", "given": "Rute", "initials": "R"}, {"family": "Amaral", "given": "Rita", "initials": "R"}, {"family": "Alves-Correia", "given": "Magna", "initials": "M"}, {"family": "Mendes", "given": "Sandra", "initials": "S"}, {"family": "Fonseca", "given": "Jo\u00e3o Almeida", "initials": "JA"}, {"family": "J\u00e1come", "given": "Cristina", "initials": "C"}], "type": "journal article", "published": "2022-01-06", "journal": {"title": "Telemed J E Health", "issn": "1556-3669", "issn-l": null}, "abstract": "Objectives:To evaluate physician's opinion and availability to participate in mHealth-related clinical studies with patient recruitment and assessment via telemedicine and to identify characteristics associated with the willingness to participate. Methods:Cross-sectional, observational study, based on an anonymous web survey conducted in May-Jun of 2020 to 237 physicians, from Portugal and Spain that collaborated with an asthma mHealth project (INSPIRERS). Results:Response rate was 51% (n = 120). Most (74%, n = 89) physicians were available to participate in such studies, but 62% anticipated lower recruiting capacity and 40% increased difficulty in obtaining quality data. Physicians aged \u226440 years, from secondary care (vs. general practitioners) and that used apps in personal life or clinical practice were more likely to be available. Conclusions:Three-quarters of the physicians were available to participate in mHealth-related clinical studies with patient recruitment and assessment through telemedicine. Age group, medical specialty, and app use were associated with the willingness to participate.", "doi": "10.1089/tmj.2021.0462", "pmid": "34990295", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-01-10T15:33:44.220Z", "modified": "2022-01-10T15:33:44.300Z"}, {"entity": "publication", "iuid": "901e928acfc04a9bab8320ab02f54b3e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/901e928acfc04a9bab8320ab02f54b3e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/901e928acfc04a9bab8320ab02f54b3e"}}, "title": "The Views and Needs of People With Parkinson Disease Regarding Wearable Devices for Disease Monitoring: Mixed Methods Exploration.", "authors": [{"family": "Kenny", "given": "Lorna", "initials": "L", "orcid": "0000-0002-5351-3091", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c99b991bb46f40c48d2bd92e392a431d.json"}}, {"family": "Moore", "given": "Kevin", "initials": "K", "orcid": "0000-0003-0712-2222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26393cb529d64dd4b4c4250b2af2cfce.json"}}, {"family": "O' Riordan", "given": "Cl\u00edona", "initials": "C", "orcid": "0000-0002-0509-3141", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eac991a073e040dcad6217fd9a272cc4.json"}}, {"family": "Fox", "given": "Siobhan", "initials": "S", "orcid": "0000-0002-6854-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a51699627a4f48efa9149b4e3642da49.json"}}, {"family": "Barton", "given": "John", "initials": "J", "orcid": "0000-0002-0671-5678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8c553326196499e8e842ea2cc53932f.json"}}, {"family": "Tedesco", "given": "Salvatore", "initials": "S", "orcid": "0000-0002-7752-2240", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0356fa19135145ad82e2a0738f0391b7.json"}}, {"family": "Sica", "given": "Marco", "initials": "M", "orcid": "0000-0003-4188-4482", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b03fc2e7f34843229b1ca469c08959b5.json"}}, {"family": "Crowe", "given": "Colum", "initials": "C", "orcid": "0000-0002-7479-9922", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb5c7f1c8b754c9b8ecde7025b1e9bc7.json"}}, {"family": "Alam\u00e4ki", "given": "Antti", "initials": "A", "orcid": "0000-0001-6293-6232", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b7b4de949974b03ac1a20387ec77ec8.json"}}, {"family": "Condell", "given": "Joan", "initials": "J", "orcid": "0000-0002-3517-2182", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56fb9f68e28547a6a93e5786726f41d7.json"}}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A", "orcid": "0000-0003-3534-456X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26229455bc3d42f6aea6b541c4d74b48.json"}}, {"family": "Timmons", "given": "Suzanne", "initials": "S", "orcid": "0000-0001-7790-9552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9bb14fd40cfb49799dd29451e885d14b.json"}}], "type": "journal article", "published": "2022-01-06", "journal": {"title": "JMIR Form Res", "issn": "2561-326X", "volume": "6", "issue": "1", "pages": "e27418", "issn-l": null}, "abstract": "Wearable devices can diagnose, monitor, and manage neurological disorders such as Parkinson disease. With a growing number of wearable devices, it is no longer a case of whether a wearable device can measure Parkinson disease motor symptoms, but rather which features suit the user. Concurrent with continued device development, it is important to generate insights on the nuanced needs of the user in the modern era of wearable device capabilities.\n\nThis study aims to understand the views and needs of people with Parkinson disease regarding wearable devices for disease monitoring and management.\n\nThis study used a mixed method parallel design, wherein survey and focus groups were concurrently conducted with people living with Parkinson disease in Munster, Ireland. Surveys and focus group schedules were developed with input from people with Parkinson disease. The survey included questions about technology use, wearable device knowledge, and Likert items about potential device features and capabilities. The focus group participants were purposively sampled for variation in age (all were aged >50 years) and sex. The discussions concerned user priorities, perceived benefits of wearable devices, and preferred features. Simple descriptive statistics represented the survey data. The focus groups analyzed common themes using a qualitative thematic approach. The survey and focus group analyses occurred separately, and results were evaluated using a narrative approach.\n\nOverall, 32 surveys were completed by individuals with Parkinson disease. Four semistructured focus groups were held with 24 people with Parkinson disease. Overall, the participants were positive about wearable devices and their perceived benefits in the management of symptoms, especially those of motor dexterity. Wearable devices should demonstrate clinical usefulness and be user-friendly and comfortable. Participants tended to see wearable devices mainly in providing data for health care professionals rather than providing feedback for themselves, although this was also important. Barriers to use included poor hand function, average technology confidence, and potential costs. It was felt that wearable device design that considered the user would ensure better compliance and adoption.\n\nWearable devices that allow remote monitoring and assessment could improve health care access for patients living remotely or are unable to travel. COVID-19 has increased the use of remotely delivered health care; therefore, future integration of technology with health care will be crucial. Wearable device designers should be aware of the variability in Parkinson disease symptoms and the unique needs of users. Special consideration should be given to Parkinson disease-related health barriers and the users' confidence with technology. In this context, a user-centered design approach that includes people with Parkinson disease in the design of technology will likely be rewarded with improved user engagement and the adoption of and compliance with wearable devices, potentially leading to more accurate disease management, including self-management.", "doi": "10.2196/27418", "pmid": "34989693", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "v6i1e27418"}], "notes": [], "created": "2022-01-10T15:33:59.352Z", "modified": "2022-01-10T15:33:59.759Z"}, {"entity": "publication", "iuid": "9600647319b848768a61f3a666f9c5b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9600647319b848768a61f3a666f9c5b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9600647319b848768a61f3a666f9c5b4"}}, "title": "Quality of training in cervical cancer radical surgery: a survey from the European Network of Young Gynaecologic Oncologists (ENYGO).", "authors": [{"family": "Bizzarri", "given": "Nicol\u00f2", "initials": "N", "orcid": "0000-0002-1727-904X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e74a49b3221461d87f46384492b5b7f.json"}}, {"family": "Pletnev", "given": "Andrei", "initials": "A"}, {"family": "Razumova", "given": "Zoia", "initials": "Z", "orcid": "0000-0001-6598-0896", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f9dd79d57f44a0ab455974d84356528.json"}}, {"family": "Zalewski", "given": "Kamil", "initials": "K"}, {"family": "Theofanakis", "given": "Charalampos", "initials": "C"}, {"family": "Selcuk", "given": "Ilker", "initials": "I"}, {"family": "Nikolova", "given": "Tanja", "initials": "T"}, {"family": "Lanner", "given": "Maximilian", "initials": "M"}, {"family": "G\u00f3mez-Hidalgo", "given": "Natalia R", "initials": "NR", "orcid": "0000-0003-3217-0453", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f3834258eca4d02b3825b5921e452b1.json"}}, {"family": "Kacperczyk-Bartnik", "given": "Joanna", "initials": "J", "orcid": "0000-0003-2539-3894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/471ce2b6e21949a4bcaa0b1aee57d217.json"}}, {"family": "Querleu", "given": "Denis", "initials": "D", "orcid": "0000-0002-3984-4812", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3971070784b9412995250d8c87ebcc27.json"}}, {"family": "Cibula", "given": "David", "initials": "D"}, {"family": "Verheijen", "given": "Ren\u00e9 H M", "initials": "RHM"}, {"family": "Fagotti", "given": "Anna", "initials": "A", "orcid": "0000-0001-5579-335X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd97a1bb600c43b4a47b2080ea6a4438.json"}}], "type": "journal article", "published": "2022-01-06", "journal": {"title": "Int J Gynecol Cancer", "issn": "1525-1438", "issn-l": null}, "abstract": "The European Society of Gynaecological Oncology (ESGO) and partners are committed to improving the training for gynecologic oncology fellows. The aim of this survey was to assess the type and level of training in cervical cancer surgery and to investigate whether the Laparoscopic Approach to Cervical Cancer (LACC) trial results impacted training in radical surgery for gynecologic oncology fellows.\n\nIn June 2020, a 47-question electronic survey was shared with European Network of Young Gynaecologic Oncologists (ENYGO) members. Specialist fellows in obstetrics and gynecology, and gynecologic oncology, from high- and low-volume centers, who started training between January 1, 2017 and January 1, 2020 or started before January 1, 2017 but finished their training at least 6 months after the LACC trial publication (October 2018), were included.\n\n81 of 125 (64.8%) respondents were included. The median time from the start of the fellowship to completion of the survey was 28 months (range 6-48). 56 (69.1%) respondents were still fellows-in-training. 6 of 56 (10.7%) and 14 of 25 (56.0%) respondents who were still in training and completed the fellowship, respectively, performed \u226510 radical hysterectomies during their training. Fellows trained in an ESGO accredited center had a higher chance to perform sentinel lymph node biopsy (60.4% vs 30.3%; p=0.027). There was no difference in the mean number of radical hysterectomies performed by fellows during fellowship before and after the LACC trial publication (8\u00b112.0 vs 7\u00b18.4, respectively; p=0.46). A significant reduction in number of minimally invasive radical hysterectomies was noted when comparing the period before and after the LACC trial (38.5% vs 13.8%, respectively; p<0.001).\n\nExposure to radical surgery for cervical cancer among gynecologic oncology fellows is low. Centralization of cervical cancer cases to high-volume centers may provide an increase in fellows' exposure to radical procedures. The LACC trial publication was associated with a decrease in minimally invasive radical hysterectomies performed by fellows.", "doi": "10.1136/ijgc-2021-002812", "pmid": "34992130", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijgc-2021-002812"}], "notes": [], "created": "2022-01-10T15:31:46.177Z", "modified": "2022-01-10T15:31:46.351Z"}, {"entity": "publication", "iuid": "13d86c561e5a47a79c5193613849a726", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13d86c561e5a47a79c5193613849a726.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13d86c561e5a47a79c5193613849a726"}}, "title": "Psychometric properties of the Fear of COVID-19 Scale: A response to de Medeiros et al. \"Psychometric properties of the Brazilian version of the Fear of COVID-19 Scale (FCV-19S)\".", "authors": [{"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "editorial", "published": "2022-01-06", "journal": {"title": "Curr Psychol", "issn": "1046-1310", "pages": "1-2", "issn-l": null}, "abstract": null, "doi": "10.1007/s12144-021-02686-4", "pmid": "35018078", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "2686"}, {"db": "pmc", "key": "PMC8734124"}], "notes": [], "created": "2022-01-13T21:00:30.676Z", "modified": "2022-01-13T21:00:30.690Z"}, {"entity": "publication", "iuid": "5099542421be45c89ca7a6a5f7f92733", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5099542421be45c89ca7a6a5f7f92733.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5099542421be45c89ca7a6a5f7f92733"}}, "title": "Is There a Link between COVID-19 and Periodontal Disease? A Narrative Review.", "authors": [{"family": "Grigoriadis", "given": "Andreas", "initials": "A", "orcid": "0000-0002-5542-2230", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2031eae513c4a7fa7e10c3bffa33683.json"}}, {"family": "R\u00e4is\u00e4nen", "given": "Ismo T", "initials": "IT"}, {"family": "P\u00e4rn\u00e4nen", "given": "Pirjo", "initials": "P"}, {"family": "Tervahartiala", "given": "Taina", "initials": "T"}, {"family": "Sorsa", "given": "Timo", "initials": "T"}, {"family": "Sakellari", "given": "Dimitra", "initials": "D"}], "type": "journal article", "published": "2022-01-06", "journal": {"title": "Eur J Dent", "issn": "1305-7456", "issn-l": null}, "abstract": "The coronavirus disease-2019 (COVID-19) pandemic greatly affected human well-being, social behavior, global economy, and healthcare systems. Everyday clinical practice in dentistry has been adjusted to the increased hazards of aerosol production by routine dental procedures. The objective of this study was to assess the existing literature to determine possible mechanisms of a relationship between COVID-19 and periodontitis, as well as describe findings from relevant epidemiological studies.Scarce data exist in the literature that directly addresses the relationship between the two diseases. However, several data describe the role of the oral cavity and periodontal tissues as portals of entry of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), and the contribution of cytokines known to be produced in periodontal disease to severe forms of COVID-19. It is also suggested from the current literature that periodontal disease, shown to be associated with systemic diseases such as diabetes mellitus, cardiovascular and respiratory diseases, shares common risk factors with-especially-severe forms of COVID-19.Further clinical studies are required to establish the relationship between these diseases. Oral hygiene performance and intact periodontal tissues can assist in mitigating the pandemic, and it is suggested that dental practitioners can contribute to identifying at-risk patients.", "doi": "10.1055/s-0041-1740223", "pmid": "34991165", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2022-01-10T15:32:00.493Z", "modified": "2022-01-10T15:33:01.416Z"}, {"entity": "publication", "iuid": "96f60f2aefe946beb5a0066138f3fcea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/96f60f2aefe946beb5a0066138f3fcea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/96f60f2aefe946beb5a0066138f3fcea"}}, "title": "Towards an optimal monoclonal antibody with higher binding affinity to the receptor-binding domain of SARS-CoV-2 spike proteins from different variants", "authors": [{"family": "Neamtu", "given": "Andrei", "initials": "A"}, {"family": "Mocci", "given": "Francesca", "initials": "F", "orcid": "0000-0003-1394-9146", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c727688989c44760a562f662759e9159.json"}}, {"family": "Laaksonen", "given": "Aatto", "initials": "A", "orcid": "0000-0001-9783-4535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3643d2a0d8094741960ef22c433ef52e.json"}}, {"family": "Barroso da Silva", "given": "Fernando L", "initials": "FL", "orcid": "0000-0003-2526-2085", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af9b9974afba4701b8c4875200458c79.json"}}], "type": "posted-content", "published": "2022-01-05", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.01.04.474958", "pmid": null, "labels": {"Category: Omicron VoC": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2022-01-21T16:20:52.980Z", "modified": "2022-01-21T16:22:00.578Z"}, {"entity": "publication", "iuid": "0c1b1ad99f3b44578c6c0520a8c6816e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c1b1ad99f3b44578c6c0520a8c6816e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c1b1ad99f3b44578c6c0520a8c6816e"}}, "title": "The ratio of cardiac troponin T to troponin I may indicate non-necrotic troponin release among COVID-19 patients.", "authors": [{"family": "Hammarsten", "given": "Ola", "initials": "O"}, {"family": "Ljungqvist", "given": "Pontus", "initials": "P"}, {"family": "Redfors", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Wernbom", "given": "Mathias", "initials": "M"}, {"family": "Widing", "given": "Hannes", "initials": "H"}, {"family": "Lindahl", "given": "Bertil", "initials": "B"}, {"family": "Salahuddin", "given": "Sabin", "initials": "S"}, {"family": "Sammantar", "given": "Ruwayda", "initials": "R"}, {"family": "Jha", "given": "Sandeep", "initials": "S"}, {"family": "Ravn-Fischer", "given": "Annica", "initials": "A"}, {"family": "Brink", "given": "Magnus", "initials": "M"}, {"family": "Gisslen", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2022-01-05", "journal": {"title": "Clin Chim Acta", "issn": "1873-3492", "issn-l": "0009-8981", "volume": "527", "issue": null, "pages": "33-37"}, "abstract": "Although cardiac troponin T (cTnT) and troponin I(cTnI) are expressed to similar amount in cardiac tissue, cTnI often reach ten-times higher peak levels compared to cTnT in patients with myocardial necrosis such as in acute myocardial infarction (MI). In contrast, similar levels of cTnT and cTnI are observed in other situations such as stable atrial fibrillation and after strenuous exercise.\n\nExamine cTnT and cTnI levels in relation to COVID-19 disease and MI.\n\nClinical and laboratory data from the local hospital from an observational cohort study of 27 patients admitted with COVID-19 and 15 patients with myocardial infarction (MI) that were analyzed with paired cTnT and cTnI measurement during hospital care.\n\nLevels of cTnI were lower than cTnT in COVID-19 patients (TnI/TnT ratio 0.3, IQR: 0.1-0.6). In contrast, levels of cTnI were 11 times higher compared to cTnT in 15 patients with MI (TnI/TnT ratio 11, IQR: 7-14). The peak cTnI/cTnT ratio among the patients with MI following successful percutaneous intervention were 14 (TnI/TnT ratio 14, IQR: 12-23). The 5 COVID-19 patient samples collected under possible necrotic events had a cTnI/cTnT ratio of 5,5 (IQR: 1,9-8,3).\n\nIn patients with COVID-19, cTnT is often elevated to higher levels than cTnI in sharp contrast to patients with MI, indicating that the release of cardiac troponin has a different cause in COVID-19 patients.", "doi": "10.1016/j.cca.2021.12.030", "pmid": "34998858", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S0009-8981(21)00459-9"}, {"db": "pmc", "key": "PMC8744390"}], "notes": [], "created": "2022-01-10T11:51:34.183Z", "modified": "2022-02-06T17:33:39.186Z"}, {"entity": "publication", "iuid": "816288de60f1430e94cf34b9fe9c777c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/816288de60f1430e94cf34b9fe9c777c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/816288de60f1430e94cf34b9fe9c777c"}}, "title": "Psychometric evaluation of fear of COVID-19 Scale (FCV-19S) among Chinese primary and middle schoolteachers, and their students.", "authors": [{"family": "Chen", "given": "I-Hua", "initials": "IH"}, {"family": "Chen", "given": "Chao-Ying", "initials": "CY"}, {"family": "Zhao", "given": "Ke-Yun", "initials": "KY"}, {"family": "Gamble", "given": "Jeffrey H", "initials": "JH"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2022-01-05", "journal": {"title": "Curr Psychol", "issn": "1046-1310", "pages": "1-17", "issn-l": null}, "abstract": "Utilizing a large-scale cross-sectional survey, the present study tested the advanced psychometric properties of Fear of COVID-19 Scale (FCV-19S) in specific populations (i.e., primary and middle schoolteachers, and their students). The present study also examined the association between perceived fear of COVID-19 and psychological distress among home-room teachers (i.e., teachers who teach all their students in one classroom all day) and their students. The results among participants (11,134 teachers and 4,335 students) indicated good internal reliability of FCV-19S and excellent factorial validity with a two-factor structure utilizing these specific populations. Furthermore, the multilevel analysis showed that home-room teachers' psychological distress, but not fear of COVID-19, was positively associated with their students. In sum, the FCV-19S is a useful tool to assess the fear of COVID-19 on potentially vulnerable populations (i.e., primary/middle schoolteachers and their students). Future studies are encouraged to use the present study's findings to investigate possible underlying mechanisms for developing effective coping strategies and interventions.\n\nThe online version contains supplementary material available at 10.1007/s12144-021-02471-3.", "doi": "10.1007/s12144-021-02471-3", "pmid": "35002189", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2471"}, {"db": "pmc", "key": "PMC8727075"}], "notes": [], "created": "2022-01-13T21:11:56.448Z", "modified": "2022-01-13T21:11:56.494Z"}, {"entity": "publication", "iuid": "8f35ecffb0674516a54335b722d34bc9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f35ecffb0674516a54335b722d34bc9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f35ecffb0674516a54335b722d34bc9"}}, "title": "Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16.", "authors": [{"family": "Kozielski", "given": "Frank", "initials": "F"}, {"family": "Sele", "given": "C\u00e9leste", "initials": "C"}, {"family": "Talibov", "given": "Vladimir O", "initials": "VO"}, {"family": "Lou", "given": "Jiaqi", "initials": "J"}, {"family": "Dong", "given": "Danni", "initials": "D"}, {"family": "Wang", "given": "Qian", "initials": "Q"}, {"family": "Shi", "given": "Xinyue", "initials": "X"}, {"family": "Nyblom", "given": "Maria", "initials": "M"}, {"family": "Rogstam", "given": "Annika", "initials": "A"}, {"family": "Krojer", "given": "Tobias", "initials": "T"}, {"family": "Fisher", "given": "Zo\u00eb", "initials": "Z", "orcid": "0000-0001-8287-0269", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84513a785fda44798344a51a5c960ff7.json"}}, {"family": "Knecht", "given": "Wolfgang", "initials": "W", "orcid": "0000-0001-9530-7598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/034349dc8d0a404c9ecb0fa6cb63b44d.json"}}], "type": "journal article", "published": "2022-01-05", "journal": {"title": "RSC Chem Biol", "issn": "2633-0679", "volume": "3", "issue": "1", "pages": "44-55", "issn-l": null}, "abstract": "Since the emergence of SARS-CoV-2 in 2019, Covid-19 has developed into a serious threat to our health, social and economic systems. Although vaccines have been developed in a tour-de-force and are now increasingly available, repurposing of existing drugs has been less successful. There is a clear need to develop new drugs against SARS-CoV-2 that can also be used against future coronavirus infections. Non-structural protein 10 (nsp10) is a conserved stimulator of two enzymes crucial for viral replication, nsp14 and nsp16, exhibiting exoribonuclease and methyltransferase activities. Interfering with RNA proofreading or RNA cap formation represents intervention strategies to inhibit replication. We applied fragment-based screening using nano differential scanning fluorometry and X-ray crystallography to identify ligands targeting SARS-CoV-2 nsp10. We identified four fragments located in two distinct sites: one can be modelled to where it would be located in the nsp14-nsp10 complex interface and the other in the nsp16-nsp10 complex interface. Microscale thermophoresis (MST) experiments were used to quantify fragment affinities for nsp10. Additionally, we showed by MST that the interaction by nsp14 and 10 is weak and thereby that complex formation could be disrupted by small molecules. The fragments will serve as starting points for the development of more potent analogues using fragment growing techniques and structure-based drug design.", "doi": "10.1039/d1cb00135c", "pmid": "35128408", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "d1cb00135c"}, {"db": "pmc", "key": "PMC8729259"}, {"db": "URL", "key": "https://www.rcsb.org/structure/7ORR", "description": "https://www.rcsb.org/structure/7ORR"}, {"db": "URL", "key": "https://www.rcsb.org/structure/7ORU", "description": "https://www.rcsb.org/structure/7ORU"}, {"db": "URL", "key": "https://www.rcsb.org/structure/7ORW", "description": "https://www.rcsb.org/structure/7ORW"}, {"db": "URL", "key": "https://www.rcsb.org/structure/7ORV", "description": "https://www.rcsb.org/structure/7ORV"}, {"db": "URL", "key": "https://zenodo.org/record/5234009#.Ygzu4d_TVBw", "description": "https://zenodo.org/record/5234009#.Ygzu4d_TVBw"}], "notes": [], "created": "2022-02-08T15:12:57.601Z", "modified": "2022-02-16T14:45:03.822Z"}, {"entity": "publication", "iuid": "f5e4a19529c9460db484bb7110e5b52b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f5e4a19529c9460db484bb7110e5b52b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f5e4a19529c9460db484bb7110e5b52b"}}, "title": "Heterologous immunization with inactivated vaccine followed by mRNA booster elicits strong humoral and cellular immune responses against the SARS-CoV-2 Omicron variant", "authors": [{"family": "Zuo", "given": "Fanglei", "initials": "F"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Piralla", "given": "Antonio", "initials": "A"}, {"family": "Bertoglio", "given": "Federico", "initials": "F"}, {"family": "de Campos-Mata", "given": "Leire", "initials": "L"}, {"family": "Wan", "given": "Hui", "initials": "H"}, {"family": "Schubert", "given": "Maren", "initials": "M"}, {"family": "Wang", "given": "Yating", "initials": "Y"}, {"family": "Sun", "given": "Rui", "initials": "R"}, {"family": "Cassaniti", "given": "Irene", "initials": "I"}, {"family": "Vlachiotis", "given": "Stelios", "initials": "S"}, {"family": "Kumagai-Braesch", "given": "Makiko", "initials": "M"}, {"family": "Andr\u00e9ll", "given": "Juni", "initials": "J"}, {"family": "Zhang", "given": "Zhaoxia", "initials": "Z"}, {"family": "Xue", "given": "Yintong", "initials": "Y"}, {"family": "Wenzel", "given": "Esther Veronika", "initials": "EV"}, {"family": "Calzolai", "given": "Luigi", "initials": "L"}, {"family": "Varani", "given": "Luca", "initials": "L"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Chavoshzadeh", "given": "Zahra", "initials": "Z"}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Hust", "given": "Michael", "initials": "M", "orcid": "0000-0003-3418-6045", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0587ca1111f84a61aaf8917a123d49c1.json"}}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}], "type": "posted-content", "published": "2022-01-05", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.01.04.22268755", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Health": null, "Category: Omicron VoC": null}, "xrefs": [], "notes": [], "created": "2022-01-12T20:54:35.413Z", "modified": "2022-01-21T15:44:21.528Z"}, {"entity": "publication", "iuid": "c10a0714bf2a447fac79cff2efabad6c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c10a0714bf2a447fac79cff2efabad6c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c10a0714bf2a447fac79cff2efabad6c"}}, "title": "Suicidal Ideation during the COVID-19 Pandemic among A Large-Scale Iranian Sample: The Roles of Generalized Trust, Insomnia, and Fear of COVID-19.", "authors": [{"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Ehsani", "given": "Narges", "initials": "N"}, {"family": "Ohayon", "given": "Maurice M", "initials": "MM"}, {"family": "Chen", "given": "Shun-Hua", "initials": "SH", "orcid": "0000-0002-6158-5829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22cb281a4d004f29ad4c944f1f6c344c.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2022-01-04", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "volume": "10", "issue": "1", "issn-l": null}, "abstract": "The novel 2019 coronavirus disease (COVID-19) is still not under control globally. The pandemic has caused mental health issues among many different cohorts and suicidal ideation in relation to COVID-19 has been reported in a number of recent studies. Therefore, the present study proposed a model to explain the associations between generalized trust, fear of COVID-19, insomnia, and suicidal ideation during the COVID-19 pandemic among a large-scale Iranian sample. Utilizing cluster sampling with multistage stratification, residents from Qazvin province in Iran were invited to participate in the present study. Adults aged over 18 years (n = 10,843; 6751 [62.3%] females) completed 'paper-and-pencil' questionnaires with the assistance of a trained research assistant. Structural equation modeling (SEM) was applied to understand the associations between generalized trust, fear of COVID-19, insomnia, and suicidal ideation. Slightly over one-fifth of the participants (n = 2252; 20.8%) reported suicidal ideation. Moreover, the SEM results indicated that generalized trust was indirectly associated with suicidal ideation via fear of COVID-19 and insomnia. Furthermore, generalized trust was not directly associated with suicidal ideation. The proposed model was invariant across gender groups, age groups, and participants residing in different areas (i.e., urban vs. rural). Generalized trust might reduce individuals' suicidal ideation during the COVID-19 pandemic period via reduced levels of fear of COVID-19 and insomnia. Healthcare providers and policymakers may want to assist individuals in developing their generalized trust, reducing fear of COVID-19, and improving insomnia problems to avoid possible suicidal behaviors.", "doi": "10.3390/healthcare10010093", "pmid": "35052258", "labels": {"Category: Public Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "healthcare10010093"}], "notes": [], "created": "2022-01-26T10:24:50.075Z", "modified": "2022-01-26T10:24:50.163Z"}, {"entity": "publication", "iuid": "85f1e00155fd49f48d305e0694acae51", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/85f1e00155fd49f48d305e0694acae51.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/85f1e00155fd49f48d305e0694acae51"}}, "title": "Structural basis of Omicron neutralization by affinity-matured public antibodies", "authors": [{"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Pushparaj", "given": "Pradeepa", "initials": "P"}, {"family": "Das", "given": "Hrishikesh", "initials": "H"}, {"family": "Kim", "given": "Changil", "initials": "C"}, {"family": "Kim", "given": "Sungyong", "initials": "S"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Dyrdak", "given": "Robert", "initials": "R", "orcid": "0000-0001-8456-4898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98ad76a0e144478cb3ceabd05c9928b0.json"}}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "H\u00e4llberg", "given": "B Martin", "initials": "BM", "orcid": "0000-0002-6781-0345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea241fd233ca40a6be4ffa1472d2aa06.json"}}], "type": "posted-content", "published": "2022-01-04", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.01.03.474825", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Health": null, "Category: Omicron VoC": null}, "xrefs": [], "notes": [], "created": "2022-01-12T20:56:05.166Z", "modified": "2023-06-19T14:45:01.436Z"}, {"entity": "publication", "iuid": "1731370beba149bda4ea02b21c210e81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1731370beba149bda4ea02b21c210e81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1731370beba149bda4ea02b21c210e81"}}, "title": "Informal caregiver support needs and burden: a survey in Lithuania.", "authors": [{"family": "Biliunaite", "given": "Ieva", "initials": "I", "orcid": "0000-0002-9111-0891", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51a4248a3ff9484bbc49137b51d2f71a.json"}}, {"family": "Kazlauskas", "given": "Evaldas", "initials": "E", "orcid": "0000-0002-6654-6220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/325ffed05ee04a7fb3aefc3dd9e168e1.json"}}, {"family": "Sanderman", "given": "Robbert", "initials": "R"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}], "type": "journal article", "published": "2022-01-04", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "1", "pages": "e054607", "issn-l": "2044-6055"}, "abstract": "A demand for informal care exists worldwide. Lithuania presents an interesting case example where the need for the informal care is increasing, but relatively little research has been conducted documenting caregivers' experiences and needs.\n\nThe main objective of this study was to investigate Lithuanian informal caregiver characteristics, support needs and burden. In addition, the impact of the COVID-19 on the caregiver's and care receiver's well-being was investigated.\n\nThe study was conducted online between May and September 2020. Informal caregivers and individuals with informal caregiving experiences were invited to participate in the survey. The survey questionnaire comprised 38 multiple-choice items including participant demographic characteristics, availability of the support, support needs, well-being and the impact of the COVID-19 pandemic. In addition, caregiver burden was assessed with the 24-item Caregiver Burden Inventory (CBI).\n\nA total of 226 individuals completed the survey. Most of the participants were women (87.6%). Almost half of the participants (48.7%) were not receiving any support, and a total of 73.9% expressed a need to receive more professional support. Participants were found to experience high burden on the CBI (M=50.21, SD=15.63). Women were found to be significantly more burdened than men (p=0.011). Even though many participants experienced psychological problems (55.8%), only 2.2% were receiving any psychological support. Finally, majority of the participants did not experience any changes in their own (63.7%) or the well-being of their care receiver (68.1%) due to the COVID-19 pandemic.\n\nMost of the participants were identified as intensive caregivers experiencing a high burden. A majority did not experience changes in their well-being due to COVID-19. We propose several recommendations for increasing accessibility and availability of support for informal caregivers in Lithuania based on the study findings.", "doi": "10.1136/bmjopen-2021-054607", "pmid": "34983768", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-054607"}], "notes": [], "created": "2022-01-10T15:42:11.114Z", "modified": "2022-01-10T15:42:27.894Z"}, {"entity": "publication", "iuid": "73e04d2e08b24dcb8c8839169bb1d85b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/73e04d2e08b24dcb8c8839169bb1d85b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/73e04d2e08b24dcb8c8839169bb1d85b"}}, "title": "Evidence of Air and Surface Contamination with SARS-CoV-2 in a Major Hospital in Portugal.", "authors": [{"family": "Silva", "given": "Priscilla Gomes da", "initials": "PGD"}, {"family": "Gon\u00e7alves", "given": "Jos\u00e9", "initials": "J", "orcid": "0000-0003-2191-527X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7bc13d9c6bec4167aca395c18335bae8.json"}}, {"family": "Lopes", "given": "Ariana Isabel Brito", "initials": "AIB"}, {"family": "Esteves", "given": "Nury Alves", "initials": "NA"}, {"family": "Bamba", "given": "Gustavo Emanuel Enes", "initials": "GEE"}, {"family": "Nascimento", "given": "Maria S\u00e3o Jos\u00e9", "initials": "MSJ", "orcid": "0000-0002-6157-4978", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54388d9b1cc447168086583c0ef4f9a5.json"}}, {"family": "Branco", "given": "Pedro T B S", "initials": "PTBS", "orcid": "0000-0002-4163-0936", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b0c4d92fbc947a2b280ab17a64e9247.json"}}, {"family": "Soares", "given": "Ruben R G", "initials": "RRG", "orcid": "0000-0001-5958-5232", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2fc2815bc25c4fb78df63294947ee184.json"}}, {"family": "Sousa", "given": "Sofia I V", "initials": "SIV", "orcid": "0000-0002-4139-673X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f368cca1ed2144718a95ef3632ba7b3a.json"}}, {"family": "Mesquita", "given": "Jo\u00e3o R", "initials": "JR", "orcid": "0000-0001-8769-8103", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/233b221fd5d7472fab41c89a19beadd5.json"}}], "type": "journal article", "published": "2022-01-04", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "1", "issn-l": null}, "abstract": "As the third wave of the COVID-19 pandemic hit Portugal, it forced the country to reintroduce lockdown measures due to hospitals reaching their full capacities. Under these circumstances, environmental contamination by SARS-CoV-2 in different areas of one of Portugal's major Hospitals was assessed between 21 January and 11 February 2021. Air samples (n = 44) were collected from eleven different areas of the Hospital (four COVID-19 and seven non-COVID-19 areas) using Coriolis\u00ae \u03bc and Coriolis\u00ae Compact cyclone air sampling devices. Surface sampling was also performed (n = 17) on four areas (one COVID-19 and three non-COVID-19 areas). RNA extraction followed by a one-step RT-qPCR adapted for quantitative purposes were performed. Of the 44 air samples, two were positive for SARS-CoV-2 RNA (6575 copies/m3 and 6662.5 copies/m3, respectively). Of the 17 surface samples, three were positive for SARS-CoV-2 RNA (200.6 copies/cm2, 179.2 copies/cm2, and 201.7 copies/cm2, respectively). SARS-CoV-2 environmental contamination was found both in air and on surfaces in both COVID-19 and non-COVID-19 areas. Moreover, our results suggest that longer collection sessions are needed to detect point contaminations. This reinforces the need to remain cautious at all times, not only when in close contact with infected individuals. Hand hygiene and other standard transmission-prevention guidelines should be continuously followed to avoid nosocomial COVID-19.", "doi": "10.3390/ijerph19010525", "pmid": "35010785", "labels": {"Category: Other": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph19010525"}], "notes": [], "created": "2022-01-13T21:07:50.384Z", "modified": "2022-01-13T21:07:59.578Z"}, {"entity": "publication", "iuid": "6229e6d010c64da2802a196b60b10ea9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6229e6d010c64da2802a196b60b10ea9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6229e6d010c64da2802a196b60b10ea9"}}, "title": "Scaling the Children Immunization App (CIMA) to Support Child Refugees and Parents in the Time of the COVID-19 Pandemic: A Social Capital Approach to Scale a Smartphone Application in Zaatari Camp, Jordan.", "authors": [{"family": "Khader", "given": "Yousef S", "initials": "YS"}, {"family": "Maalouf", "given": "Wadih", "initials": "W"}, {"family": "Khdair", "given": "Mohammad Abu", "initials": "MA"}, {"family": "Al-Nsour", "given": "Mohannad", "initials": "M"}, {"family": "Aga", "given": "Eresso", "initials": "E"}, {"family": "Khalifa", "given": "Adam", "initials": "A"}, {"family": "Kassasbeh", "given": "Mohamad", "initials": "M"}, {"family": "El-Halabi", "given": "Soha", "initials": "S"}, {"family": "Alfven", "given": "Tobias", "initials": "T"}, {"family": "El-Khatib", "given": "Ziad", "initials": "Z", "orcid": "0000-0003-0756-7280", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31747e0476314de9bf53d8c8f3d1d147.json"}}], "type": "journal article", "published": "2022-01-03", "journal": {"title": "J Epidemiol Glob Health", "issn": "2210-6014", "issn-l": null}, "abstract": "Children vaccination is a key intervention for their survival, especially among refugees. Yet, children vaccination registration is done manually in refugees camps and there is no possibility to send reminders to parents to come back on time. We aimed to boost the parental registration of children's vaccination records on a Children Immunization app (CIMA) while also availing the parents with useful parenting skills under COVID-19-related stress.\n\nWe incorporated United Nations Office on Drugs and Crime (UNODC) Parenting Skills under COVID-19 information material, through CIMA in Arabic and English languages. We recruited 1100 children in February-March 2021, through a community health promotion dissemination approach. A team of two nurses from the local population and two volunteers (one trained nurse and one trained social worker), from the camp, was formed. They promoted the CIMA app at two clinics and through households visits in Zaatari refugee camp. Qualitative data on impressions and observations of the interactions with the Zaatari camp community were also collected.\n\nA total of 1100 children, up to 15 months of age, eligible for vaccination were enrolled in CIMA, whereby the staff explained the content of the app in terms of vaccination schedule, health promotion materials for vaccination and parenting skills to their caregivers. During the household visits, the volunteers identified a total of 70 children that have incomplete history of vaccination records (n = 42/70 girls, 60%). Also, opportunities and challenges for scaling the app were documented.\n\nThe scaling of CIMA as an innovative means of dissemination of risk and health information in challenging context such as refugee camps was feasible. In the context of vaccination needs for children, in refugee settings, such a need is more eminent, particularly in the context of COVID-19.", "doi": "10.1007/s44197-021-00029-x", "pmid": "34978708", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s44197-021-00029-x"}, {"db": "pmc", "key": "PMC8721635"}], "notes": [], "created": "2022-01-04T14:43:02.544Z", "modified": "2022-01-10T15:43:57.754Z"}, {"entity": "publication", "iuid": "790d80d81559486d90955b9d06bec5fb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/790d80d81559486d90955b9d06bec5fb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/790d80d81559486d90955b9d06bec5fb"}}, "title": "COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease - 3rd CIAO AOP Design Workshop.", "authors": [{"family": "Clerbaux", "given": "Laure-Alix", "initials": "LA"}, {"family": "Amig\u00f3", "given": "N\u00faria", "initials": "N"}, {"family": "Amorim", "given": "Maria Jo\u00e3o", "initials": "MJ"}, {"family": "Bal-Price", "given": "Anna", "initials": "A"}, {"family": "Batista Leite", "given": "Sofia", "initials": "S"}, {"family": "Beronius", "given": "Anna", "initials": "A"}, {"family": "Bezemer", "given": "Gillina F G", "initials": "GFG"}, {"family": "Bostroem", "given": "Ann-Charlotte", "initials": "AC"}, {"family": "Carusi", "given": "Annamaria", "initials": "A"}, {"family": "Coecke", "given": "Sandra", "initials": "S"}, {"family": "Concha", "given": "Rachel", "initials": "R"}, {"family": "Daskalopoulos", "given": "Evangelos P", "initials": "EP"}, {"family": "Debernardi", "given": "Francesca", "initials": "F"}, {"family": "Edrosa", "given": "Eizleayne", "initials": "E"}, {"family": "Edwards", "given": "Steve W", "initials": "SW"}, {"family": "Filipovska", "given": "Julija", "initials": "J"}, {"family": "Garcia-Reyero", "given": "Nat\u00e0lia", "initials": "N"}, {"family": "Gavins", "given": "Felicity N E", "initials": "FNE"}, {"family": "Halappanavar", "given": "Sabina", "initials": "S"}, {"family": "Hargreaves", "given": "Alan J", "initials": "AJ"}, {"family": "Hogberg", "given": "Helena T", "initials": "HT"}, {"family": "Huynh", "given": "Myl\u00e8ne T", "initials": "MT"}, {"family": "Jacobson", "given": "Daniel", "initials": "D"}, {"family": "Josephs-Spaulding", "given": "Jonathan", "initials": "J"}, {"family": "Kim", "given": "Young Jun", "initials": "YJ"}, {"family": "Kong", "given": "Hyun Joon", "initials": "HJ"}, {"family": "Krebs", "given": "Catharine E", "initials": "CE"}, {"family": "Lam", "given": "Ann", "initials": "A"}, {"family": "Landesmann", "given": "Brigitte", "initials": "B"}, {"family": "Layton", "given": "Adrienne", "initials": "A"}, {"family": "Lee", "given": "Yong Oh", "initials": "YO"}, {"family": "Macmillan", "given": "Donna S", "initials": "DS"}, {"family": "Mantovani", "given": "Alberto", "initials": "A"}, {"family": "Margiotta-Casaluci", "given": "Luigi", "initials": "L"}, {"family": "Martens", "given": "Marvin", "initials": "M"}, {"family": "Masereeuw", "given": "Rosalinde", "initials": "R"}, {"family": "Mayasich", "given": "Sally A", "initials": "SA"}, {"family": "Mei", "given": "Liang Merlin", "initials": "LM"}, {"family": "Mortensen", "given": "Holly", "initials": "H"}, {"family": "Munoz Pineiro", "given": "Amalia", "initials": "A"}, {"family": "Nymark", "given": "Penny", "initials": "P"}, {"family": "Ohayon", "given": "Elan", "initials": "E"}, {"family": "Ojasi", "given": "Joshi", "initials": "J"}, {"family": "Paini", "given": "Alicia", "initials": "A"}, {"family": "Parissis", "given": "Nikolaos", "initials": "N"}, {"family": "Parvatam", "given": "Surat", "initials": "S"}, {"family": "Pistollato", "given": "Francesca", "initials": "F"}, {"family": "Sachana", "given": "Magdalini", "initials": "M"}, {"family": "S\u00f8rli", "given": "Jorid Birkelund", "initials": "JB"}, {"family": "Sullivan", "given": "Kristie M", "initials": "KM"}, {"family": "Sund", "given": "Jukka", "initials": "J"}, {"family": "Tanabe", "given": "Shihori", "initials": "S"}, {"family": "Tsaioun", "given": "Katya", "initials": "K"}, {"family": "Vinken", "given": "Mathieu", "initials": "M"}, {"family": "Viviani", "given": "Laura", "initials": "L"}, {"family": "Waspe", "given": "Jennifer", "initials": "J"}, {"family": "Willett", "given": "Catherine", "initials": "C"}, {"family": "Wittwehr", "given": "Clemens", "initials": "C"}], "type": "editorial", "published": "2022-01-03", "journal": {"title": "ALTEX", "issn": "1868-596X", "issn-l": null}, "abstract": "On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO workshop. The CIAO project \"Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework\" aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological key events (KE) toward an adverse outcome, such as respiratory distress, anosmia or multiorgan failure. Assembling the individual AOPs into a network highlights shared KEs as central biological nodes involved in multiple outcomes observed in COVID-19 patients. During the workshop, the KEs and AOPs established so far by the CIAO members were presented and positioned on a timeline of the disease course. Modulating factors influencing the progression and severity of the disease were also addressed, as well as factors beyond purely biological phenomena. CIAO relies on an interdisciplinary crowdsourcing effort, therefore, approaches to expand the CIAO network by widening the crowd and reaching stakeholders were also discussed. To conclude the workshop, it was decided that the AOPs/KEs will be further consolidated, integrating viral variants and long COVID when relevant, while an outreach campaign will be launched to broaden the CIAO scientific crowd.", "doi": "10.14573/altex.2112161", "pmid": "35032963", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2022-01-27T08:01:19.129Z", "modified": "2022-01-27T08:01:19.141Z"}, {"entity": "publication", "iuid": "e8c30921f2d5452399e9ee79e9b6029c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e8c30921f2d5452399e9ee79e9b6029c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e8c30921f2d5452399e9ee79e9b6029c"}}, "title": "Inclusion of Essential Universal Health Coverage Services in Essential Packages of Health Services: A Review of 45 Low- and Lower- Middle Income Countries.", "authors": [{"family": "Shekh Mohamed", "given": "Idil", "initials": "I", "orcid": "0000-0001-8793-601X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/530ee0a9cc58442aafd51798fc54a8fe.json"}}, {"family": "Hepburn", "given": "Jasmine Sprague", "initials": "JS", "orcid": "0000-0002-0917-3181", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b48672dcc13b4596a58890e94992ffdf.json"}}, {"family": "Ekman", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0001-7630-7904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1f4d8ed39cc483a802c179c1f37c53d.json"}}, {"family": "Sundewall", "given": "Jesper", "initials": "J", "orcid": "0000-0001-5357-5754", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c5701bdabae44638729d729958821db.json"}}], "type": "journal article", "published": "2022-01-01", "journal": {"title": "Health Syst Reform", "issn": "2328-8620", "volume": "8", "issue": "1", "pages": "e2006587", "issn-l": null}, "abstract": "Expanding service coverage and achieving universal health coverage (UHC) is a priority for many low- and middle-income countries. Though UHC is a long-term goal, its importance and relevance have only increased since the start of the COVID-19 pandemic. The first step on the road to UHC is to define and develop essential packages of health services (EPHSs), a list of clinical and public health services that a government has deemed a priority and is to provide. However, the nature of these lists of services in low- and lower-middle-income countries is largely unknown. This study examines the contents of 45 countries' EPHSs to determine the inclusion of essential UHC (EUHC) services as defined by the Disease Control Priorities, which comprises 21 specific essential packages of interventions. EPHSs were collected from publicly available sources and their contents were analyzed in two stages, firstly, to determine the level of specificity and detail of the content of EPHSs and, secondly, to determine which essential UHC services were included. Findings show that there are large variations in the level of specificity among EPHSs and that though EUHC services are included to a large extent, variations exist regarding which services are included between countries. The results provide an overview of how countries are designing EPHSs as a policy tool and are progressing toward providing a full range of EUHC services. Additionally, the study introduces new tools and methods for UHC policy analysts and researchers to study the contents of EPHSs in future investigations.", "doi": "10.1080/23288604.2021.2006587", "pmid": "35060830", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2022-01-26T10:20:24.847Z", "modified": "2022-01-26T10:20:24.998Z"}, {"entity": "publication", "iuid": "255e08a4b562434cb10d5c4b99e40fbe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/255e08a4b562434cb10d5c4b99e40fbe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/255e08a4b562434cb10d5c4b99e40fbe"}}, "title": "COVID-19 Pulmonary Pathology: The Experience of European Pulmonary Pathologists throughout the First Two Waves of the Pandemic.", "authors": [{"family": "Fortarezza", "given": "Francesco", "initials": "F"}, {"family": "Pezzuto", "given": "Federica", "initials": "F", "orcid": "0000-0002-8023-3108", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f2021982e9bc4f2aa6c75fc8ea679bc5.json"}}, {"family": "Hofman", "given": "Paul", "initials": "P", "orcid": "0000-0003-0431-9353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80753da68c474a46a5fd85c76e468fdb.json"}}, {"family": "Kern", "given": "Izidor", "initials": "I"}, {"family": "Panizo", "given": "Angel", "initials": "A", "orcid": "0000-0001-8405-7378", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3510815aee214ab7bc89ac6ea9af60b6.json"}}, {"family": "von der Th\u00fcsen", "given": "Jan", "initials": "J", "orcid": "0000-0001-9699-4860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/703d4cdc0b10482391d986defbfe0b9a.json"}}, {"family": "Timofeev", "given": "Sergei", "initials": "S", "orcid": "0000-0002-7098-9024", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dbf89525c1b40ae968ebacad2cf26b8.json"}}, {"family": "Gorkiewicz", "given": "Gregor", "initials": "G", "orcid": "0000-0003-1149-4782", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7745a0222ee340a4897d7bd58f6d4e7f.json"}}, {"family": "Berezowska", "given": "Sabina", "initials": "S", "orcid": "0000-0001-5442-9791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61f52024cff94937b61c28841e8f9912.json"}}, {"family": "de Level", "given": "Laurence", "initials": "L", "orcid": "0000-0003-3994-516X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c0844df584e45b88b88f785e3e272cf.json"}}, {"family": "Ortiz-Villal\u00f3n", "given": "Cristian", "initials": "C"}, {"family": "Lunardi", "given": "Francesca", "initials": "F", "orcid": "0000-0001-5792-4683", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/702db0cd99754d57994f3a5f0e2beb4a.json"}}, {"family": "Calabrese", "given": "Fiorella", "initials": "F"}], "type": "journal article", "published": "2022-01-01", "journal": {"title": "Diagnostics (Basel)", "issn": "2075-4418", "volume": "12", "issue": "1", "issn-l": null}, "abstract": "Autoptic studies of patients who died from COVID-19 constitute an important step forward in improving our knowledge in the pathophysiology of SARS-CoV-2 infection. Systematic analyses of lung tissue, the organ primarily targeted by the disease, were mostly performed during the first wave of the pandemic. Analyses of pathological lesions at different times offer a good opportunity to better understand the disease and how its evolution has been influenced mostly by new SARS-CoV-2 variants or the different therapeutic approaches. In this short report we summarize responses collected from a questionnaire survey that investigated important pathological data during the first two pandemic waves (spring-summer 2020; autumn-winter 2020-2021). The survey was submitted to expert lung pathologists from nine European countries involved in autoptic procedures in both pandemic waves. The frequency of each lung lesion was quite heterogeneous among the participants. However, a higher frequency of pulmonary superinfections, both bacterial and especially fungal, was observed in the second wave compared to the first. Obtaining a deeper knowledge of the pathological lesions at the basis of this complex and severe disease, which change over time, is crucial for correct patient management and treatment. Autoptic examination is a useful tool to achieve this goal.", "doi": "10.3390/diagnostics12010095", "pmid": "35054262", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "diagnostics12010095"}], "notes": [], "created": "2022-01-26T10:21:31.500Z", "modified": "2022-01-26T10:21:31.796Z"}, {"entity": "publication", "iuid": "b7ee308346fa414fb9d99656c2200991", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b7ee308346fa414fb9d99656c2200991.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b7ee308346fa414fb9d99656c2200991"}}, "title": "Soluble TNF receptors predict acute kidney injury and mortality in critically ill COVID-19 patients: A prospective observational study", "authors": [{"family": "Sancho Ferrando", "given": "Elena", "initials": "E"}, {"family": "Hanslin", "given": "Katja", "initials": "K"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Larsson", "given": "Anders", "initials": "A", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2be858ab604743b72383dfdcd14689.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}], "type": "journal-article", "published": "2022-01-00", "journal": {"title": "Cytokine", "issn": "1043-4666", "issn-l": null, "volume": "149", "issue": null, "pages": "155727"}, "abstract": null, "doi": "10.1016/j.cyto.2021.155727", "pmid": "34628127", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:53:51.144Z", "modified": "2022-02-15T08:24:46.792Z"}, {"entity": "publication", "iuid": "036acb2ce314488696558f11b81b706b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/036acb2ce314488696558f11b81b706b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/036acb2ce314488696558f11b81b706b"}}, "title": "Salivary IgG to SARS-CoV-2 indicates seroconversion and correlates to serum neutralization in mRNA-vaccinated immunocompromised individuals", "authors": [{"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "Pin", "given": "Elisa", "initials": "E", "orcid": "0000-0002-2158-2674", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5568b1a9e3c456c8ee4a95eaa55b103.json"}}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "S\u00f6derdahl", "given": "Gunnar", "initials": "G"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "Mielke", "given": "Stephan", "initials": "S", "orcid": "0000-0002-8325-9215", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6f17a7cc4774614a3ad5ea9c910d75a.json"}}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Bergman", "given": "Peter", "initials": "P", "orcid": "0000-0003-3306-3713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15b7290255814a7b9a1a97c3cdb2fc26.json"}}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Valentini", "given": "Davide", "initials": "D"}, {"family": "Blennow", "given": "Ola", "initials": "O", "orcid": "0000-0002-7167-7882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2318c3973e66443aa14fceca0908d127.json"}}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Gabarrini", "given": "Giorgio", "initials": "G", "orcid": "0000-0001-6936-4919", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a032980c1f294d1890979602c1a0326c.json"}}, {"family": "Al-Manei", "given": "Khaled", "initials": "K", "orcid": "0000-0003-0787-5849", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b311d335e194bba9d46406e1b73181a.json"}}, {"family": "Alkharaan", "given": "Hassan", "initials": "H"}, {"family": "Sobkowiak", "given": "Micha\u0142 Jacek", "initials": "MJ", "orcid": "0000-0003-2932-1994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f50e79d47d6845a7aeaf6deb5fe545e7.json"}}, {"family": "Yousef", "given": "Jamil", "initials": "J"}, {"family": "Mravinacova", "given": "Sara", "initials": "S"}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Xu", "given": "Xinling", "initials": "X"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K", "orcid": "0000-0001-7679-9494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02d4d3d9ccc547f7ab18ba69493f6a34.json"}}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C", "orcid": "0000-0003-0880-5375", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7394cf1c96945888fc8765568f5407c.json"}}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}, {"family": "Ljunggren", "given": "Hans Gustaf", "initials": "HG"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Aleman", "given": "Soo", "initials": "S", "orcid": "0000-0003-0461-4870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b0edb2db8d840989936f67047ce91de.json"}}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M"}], "type": "journal-article", "published": "2022-01-00", "journal": {"title": "Med (N Y)", "issn": "2666-6340", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Immunocompromised individuals are highly susceptible to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Whether vaccine-induced immunity in these individuals involves oral cavity, a primary site of infection, is presently unknown.\r\n\r\nImmunocompromised patients (n=404) and healthy controls (n=82) participated in a prospective clinical trial (NCT04780659) encompassing two doses of the mRNA BNT162b2 vaccine. Primary immunodeficiency (PID), secondary immunodeficiencies caused by human immunodeficiency virus (HIV) infection, allogeneic hematopoietic stem cell transplantation (HSCT)/chimeric antigen receptor T cell therapy (CAR-T), solid organ transplantation (SOT), and chronic lymphocytic leukemia (CLL) patients were included. Salivary and serum immunoglobulin G (IgG) reactivities to SARS-CoV-2 spike were measured by multiplex bead-based assays and Elecsys\u00ae Anti-SARS-CoV-2 S assay.\r\n\r\nIgG responses to SARS-CoV-2 spike antigens in saliva in HIV and HSCT/CAR-T groups were comparable to healthy controls after vaccination. The PID, SOT, and CLL patients had weaker responses, influenced mainly by disease parameters or immunosuppressants. Salivary responses correlated remarkably well with specific IgG titers and the neutralizing capacity in serum. Receiver operating characteristic curve analysis for the predictive power of salivary IgG yielded AUC=0.95, PPV=90.7% for entire cohort after vaccination.\r\n\r\nSaliva conveys vaccine responses induced by mRNA BNT162b2. The predictive power of salivary Spike-IgG makes it highly suitable for screening vulnerable groups for revaccination.\r\n\r\nKnut and Alice Wallenberg Foundation, Erling Perssons family foundation, Region Stockholm, Swedish Research Council, Karolinska Institutet, Swedish Blood Cancer Foundation, PID patient organization of Sweden, Nordstjernan AB, Center for Medical Innovation (CIMED), Swedish Medical Research Council, Stockholm County Council (ALF).", "doi": "10.1016/j.medj.2022.01.001", "pmid": "35075450", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null, "Research Area: Vaccine": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S2666-6340(22)00036-8"}, {"db": "pmc", "key": "PMC8770252"}], "notes": [], "created": "2022-01-26T08:15:37.719Z", "modified": "2022-02-08T19:21:59.070Z"}, {"entity": "publication", "iuid": "d14fe499bb034711ad8edfcb089c9e8f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d14fe499bb034711ad8edfcb089c9e8f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d14fe499bb034711ad8edfcb089c9e8f"}}, "title": "Robust humoral and cellular immune responses and low risk for reinfection at least 8 months following asymptomatic to mild COVID-19.", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f28f2f6ac9648629c2d2de92fe7bb59.json"}}, {"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/305bca9e5c6c423898c272bf06ce2f2a.json"}}, {"family": "Jernbom Falk", "given": "August", "initials": "A", "orcid": "0000-0002-7773-1851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40d944d7fa964f4292f10012356a2730.json"}}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N", "orcid": "0000-0003-1492-9745", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb052bdf68e4475acf519080b8ac386.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c735ef404391493980e4e51d70459ce0.json"}}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Laur\u00e9n", "given": "Ida", "initials": "I"}, {"family": "Gabrielsson", "given": "Lena", "initials": "L"}, {"family": "Salomonsson", "given": "Ann-Christin", "initials": "AC"}, {"family": "Aguilera", "given": "Katherina", "initials": "K"}, {"family": "Kihlgren", "given": "Martha", "initials": "M"}, {"family": "M\u00e5nsson", "given": "Maja", "initials": "M"}, {"family": "Rosell", "given": "Axel", "initials": "A", "orcid": "0000-0001-6280-0562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4da18c480a2d4c80ad6c7d1f97bbf917.json"}}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C", "orcid": "0000-0003-0880-5375", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7394cf1c96945888fc8765568f5407c.json"}}, {"family": "Andersson", "given": "Eni", "initials": "E"}, {"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc2c612e12284831866002f6759932d5.json"}}, {"family": "Skoglund", "given": "Lovisa", "initials": "L"}, {"family": "Yousef", "given": "Jamil", "initials": "J", "orcid": "0000-0001-5915-1258", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/324e111715fc4029badd136232057025.json"}}, {"family": "Pin", "given": "Elisa", "initials": "E", "orcid": "0000-0002-2158-2674", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5568b1a9e3c456c8ee4a95eaa55b103.json"}}, {"family": "Lord", "given": "Martin", "initials": "M", "orcid": "0000-0002-3238-3187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ddcd91137ed4f8c88b2beb2db340081.json"}}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M", "orcid": "0000-0002-7858-8233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb515ec509a94036b64bd69339bc2401.json"}}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Tegel", "given": "Hanna", "initials": "H"}, {"family": "D\u00f6nnes", "given": "Pierre", "initials": "P", "orcid": "0000-0002-4613-2952", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6924b18d27749ad99d20c69442ea52b.json"}}, {"family": "Phillipson", "given": "Mia", "initials": "M", "orcid": "0000-0002-2387-0266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/614a4a6f69204c6287a81a79a1a7a8f1.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Mangsbo", "given": "Sara", "initials": "S", "orcid": "0000-0002-1355-2678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cf494629d8a4f9584ada4be16dff66b.json"}}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1345-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a53a433db6f04a458e3d420f0c9995c5.json"}}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": "291", "issue": "1", "pages": "72-80"}, "abstract": "Emerging data support detectable immune responses for months after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination, but it is not yet established to what degree and for how long protection against reinfection lasts.\n\nWe investigated SARS-CoV-2-specific humoral and cellular immune responses more than 8 months post-asymptomatic, mild and severe infection in a cohort of 1884 healthcare workers (HCW) and 51 hospitalized COVID-19 patients. Possible protection against SARS-CoV-2 reinfection was analyzed by a weekly 3-month polymerase chain reaction (PCR) screening of 252 HCW that had seroconverted 7 months prior to start of screening and 48 HCW that had remained seronegative at multiple time points.\n\nAll COVID-19 patients and 96% (355/370) of HCW who were anti-spike IgG positive at inclusion remained anti-spike IgG positive at the 8-month follow-up. Circulating SARS-CoV-2-specific memory T cell responses were detected in 88% (45/51) of COVID-19 patients and in 63% (233/370) of seropositive HCW. The cumulative incidence of PCR-confirmed SARS-CoV-2 infection was 1% (3/252) among anti-spike IgG positive HCW (0.13 cases per 100 weeks at risk) compared to 23% (11/48) among anti-spike IgG negative HCW (2.78 cases per 100 weeks at risk), resulting in a protective effect of 95.2% (95% CI 81.9%-99.1%).\n\nThe vast majority of anti-spike IgG positive individuals remain anti-spike IgG positive for at least 8 months regardless of initial COVID-19 disease severity. The presence of anti-spike IgG antibodies is associated with a substantially reduced risk of reinfection up to 9 months following asymptomatic to mild COVID-19.", "doi": "10.1111/joim.13387", "pmid": "34459525", "labels": {"Research Area: Viral sequence evolution": null, "Research Area: Drug discovery and repurposing of drugs": null, "Category: Biochemistry": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Biobanks for COVID-19 research": null, "Research Area: Host cell systems biology and targets": null}, "xrefs": [{"db": "pmc", "key": "PMC8661920"}], "notes": [], "created": "2021-09-01T07:50:22.235Z", "modified": "2022-02-06T17:12:35.708Z"}, {"entity": "publication", "iuid": "b7c57303c3964ef7ab66ba926324329d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b7c57303c3964ef7ab66ba926324329d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b7c57303c3964ef7ab66ba926324329d"}}, "title": "Rehabilitation needs following COVID-19: Five-month post-discharge clinical follow-up of individuals with concerning self-reported symptoms.", "authors": [{"family": "Wahlgren", "given": "Carl", "initials": "C"}, {"family": "Divanoglou", "given": "Anestis", "initials": "A"}, {"family": "Larsson", "given": "Melanie", "initials": "M"}, {"family": "Nilsson", "given": "Emma", "initials": "E"}, {"family": "\u00d6stholm Balkhed", "given": "\u00c5se", "initials": "\u00c5"}, {"family": "Niward", "given": "Katarina", "initials": "K"}, {"family": "Birberg Thornberg", "given": "Ulrika", "initials": "U"}, {"family": "Lilliecreutz Gudmundsson", "given": "Eva", "initials": "E"}, {"family": "Levi", "given": "Richard", "initials": "R"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": "43", "pages": "101219", "issn-l": null}, "abstract": "This report describes and objectivizes reported problems among a cohort of previously hospitalized COVID-19 patients by clinical examination and determination of the required level of rehabilitation sevices.\n\nThis report forms part of the Link\u00f6ping COVID-19 Study (LinCoS) that included 745 individuals from one of 21 Swedish healthcare regions, Region \u00d6sterg\u00f6tland (R\u00d6), admitted to hospital for COVID-19 during March 1st-May 31st, 2020. In this descriptive ambidirectional cohort study, all 185 individuals who had reported concerning persisting symptoms were invited to a multi-professional clinical assessment of somatic, functional, affective, neuropsychological status and rehabilitation needs. Rehabilitation needs were assessed using three sub-scales of the Rehabilitation Complexity Scale-Extended.\n\nAmong the 158 (85\u00b74%) cases consenting and included in the analysis, we found a broad array of symptoms and signs attributable to COVID-19 involving respiratory, visual, auditory, motor, sensory and cognitive functions that could be confirmed clinically at five months post-discharge. This translated into 16% [95% CI 13-20] of survivors (70/433) of the total regional cohort of hospitalised patients requiring further rehabilitative interventions at follow-up. Weakness in extremities was reported in 28\u00b75% [21\u00b76, 36\u00b72] (45/158). On examination, clinically overt muscle weakness could be corroborated in 15 individuals (10\u00b75%) [6\u00b71, 16\u00b74]. 48% [40, 56] (76/158) reported cognitive symptoms, while the physician noted overt cognitive impairments in only 3% [1\u00b71, 7\u00b75]. In neuropsychological testing, 37% [28-46] (45/122) performed 1.5 SD below the norm, indicating neurocognitive deficits. Fifty-five individuals (34\u00b78%) [27\u00b74, 42\u00b78] reported new or aggravated pain. In three fourths of them, it exerted a 'moderate' or worse detrimental effect on their ability to work.\n\nOur study underscores the importance of providing extensive examination of cases with persisting problems after COVID-19, especially since symptoms such as fatigue and breathlessness are highly nonspecific, but may represent significant underlying functional impairments. Robust neurocognitive testing should be performed, as cognitive problems may easily be overlooked during routine medical consultation. In the Swedish context, most rehabilitative interventions could be provided in a primary care setting. A substantial minority of patients should be triaged to specialized rehabilitation services.", "doi": "10.1016/j.eclinm.2021.101219", "pmid": "34901798", "labels": {"Category: Rehabilitation": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(21)00500-9"}, {"db": "pmc", "key": "PMC8645256"}], "notes": [], "created": "2021-12-18T17:59:27.619Z", "modified": "2021-12-18T17:59:27.633Z"}, {"entity": "publication", "iuid": "67fddc2eeb544fe988649656d7cfb401", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/67fddc2eeb544fe988649656d7cfb401.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/67fddc2eeb544fe988649656d7cfb401"}}, "title": "Reduced risk of hospitalisation among reported COVID-19 cases infected with the SARS-CoV-2 Omicron BA.1 variant compared with the Delta variant, Norway, December 2021 to January 2022.", "authors": [{"family": "Veneti", "given": "Lamprini", "initials": "L"}, {"family": "B\u00f8\u00e5s", "given": "H\u00e5kon", "initials": "H"}, {"family": "Br\u00e5then Kristoffersen", "given": "Anja", "initials": "A"}, {"family": "St\u00e5lcrantz", "given": "Jeanette", "initials": "J"}, {"family": "Bragstad", "given": "Karoline", "initials": "K"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "Storm", "given": "Margrethe Larsdatter", "initials": "ML"}, {"family": "Aasand", "given": "Nina", "initials": "N"}, {"family": "R\u00f8", "given": "Gunnar", "initials": "G"}, {"family": "Starrfelt", "given": "Jostein", "initials": "J"}, {"family": "Sepp\u00e4l\u00e4", "given": "Elina", "initials": "E"}, {"family": "Kv\u00e5le", "given": "Reidar", "initials": "R"}, {"family": "Vold", "given": "Line", "initials": "L"}, {"family": "Nyg\u00e5rd", "given": "Karin", "initials": "K"}, {"family": "Buanes", "given": "Eirik Alnes", "initials": "EA"}, {"family": "Whittaker", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "27", "issue": "4", "issn-l": null}, "abstract": "We included 39,524 COVID-19 Omicron and 51,481 Delta cases reported in Norway from December 2021 to January 2022. We estimated a 73% reduced risk of hospitalisation (adjusted hazard ratio: 0.27; 95% confidence interval: 0.20-0.36) for Omicron compared with Delta. Compared with unvaccinated groups, Omicron cases who had completed primary two-dose vaccination 7-179 days before diagnosis had a lower reduced risk than Delta (66% vs 93%). People vaccinated with three doses had a similar risk reduction (86% vs 88%).", "doi": "10.2807/1560-7917.ES.2022.27.4.2200077", "pmid": "35086614", "labels": {"Category: Health": null, "Category: Omicron VoC": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-31T11:43:40.150Z", "modified": "2022-01-31T11:43:40.164Z"}, {"entity": "publication", "iuid": "b3e8607d21ca42449bcaf014acc8d025", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b3e8607d21ca42449bcaf014acc8d025.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b3e8607d21ca42449bcaf014acc8d025"}}, "title": "Persistent endotheliopathy in the pathogenesis of long COVID syndrome: Comment from von Meijenfeldt et al.", "authors": [{"family": "von Meijenfeldt", "given": "Fien A", "initials": "FA", "orcid": "0000-0003-0274-2414", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76b5cb67f6e243459441f06d41f0816c.json"}}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Adelmeijer", "given": "Jelle", "initials": "J"}, {"family": "Thalin", "given": "Charlotte", "initials": "C"}, {"family": "Lisman", "given": "Ton", "initials": "T", "orcid": "0000-0002-3503-7140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7431e810d13c443ca5dacbf5d368e60b.json"}}], "type": "letter", "published": "2022-01-00", "journal": {"title": "J Thromb Haemost", "issn": "1538-7836", "volume": "20", "issue": "1", "pages": "267-269", "issn-l": null}, "abstract": "To the Editor: With great interest we read the recent brief report by dr. Fogarty and colleagues providing evidence for persistent endothelial cell activation in convalescent COVID-19 patients [1]. The authors showed that plasma levels of von Willebrand factor (VWF), factor VIII, and soluble thrombomodulin were elevated at a median of 68 days after initial COVID-19 symptom resolution or discharge from the hospital. Interestingly, not all these patients experienced severe disease. Levels of endothelial injury markers were associated with long-term symptoms, including dyspnoea, fatigue and concentration impairment, often referred to as long COVID.", "doi": "10.1111/jth.15580", "pmid": "34731533", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8646477"}], "notes": [], "created": "2021-11-08T09:15:44.315Z", "modified": "2022-02-06T17:17:13.773Z"}, {"entity": "publication", "iuid": "46f10e72a5c1456791b0fcee1e08b0ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46f10e72a5c1456791b0fcee1e08b0ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46f10e72a5c1456791b0fcee1e08b0ca"}}, "title": "Modelling the direct virus exposure risk associated with respiratory events.", "authors": [{"family": "Wang", "given": "Jietuo", "initials": "J", "orcid": "0000-0002-0422-8024", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/365ae54f06934c93aff3fd56f6bb03c2.json"}}, {"family": "Dalla Barba", "given": "Federico", "initials": "F"}, {"family": "Roccon", "given": "Alessio", "initials": "A"}, {"family": "Sardina", "given": "Gaetano", "initials": "G"}, {"family": "Soldati", "given": "Alfredo", "initials": "A"}, {"family": "Picano", "given": "Francesco", "initials": "F", "orcid": "0000-0002-3943-8187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b1cf61e22c3421498d87d8df32ef247.json"}}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "J R Soc Interface", "issn": "1742-5662", "volume": "19", "issue": "186", "pages": "20210819", "issn-l": null}, "abstract": "The outbreak of the COVID-19 pandemic highlighted the importance of accurately modelling the pathogen transmission via droplets and aerosols emitted while speaking, coughing and sneezing. In this work, we present an effective model for assessing the direct contagion risk associated with these pathogen-laden droplets. In particular, using the most recent studies on multi-phase flow physics, we develop an effective yet simple framework capable of predicting the infection risk associated with different respiratory activities in different ambient conditions. We start by describing the mathematical framework and benchmarking the model predictions against well-assessed literature results. Then, we provide a systematic assessment of the effects of physical distancing and face coverings on the direct infection risk. The present results indicate that the risk of infection is vastly impacted by the ambient conditions and the type of respiratory activity, suggesting the non-existence of a universal safe distance. Meanwhile, wearing face masks provides excellent protection, effectively limiting the transmission of pathogens even at short physical distances, i.e. 1 m.", "doi": "10.1098/rsif.2021.0819", "pmid": "35016556", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Funder: VR": null}, "xrefs": [{"db": "URL", "key": "http://dx.doi.org/10.6084/m9.figshare.16826374", "description": "http://dx.doi.org/10.6084/m9.figshare.16826374"}], "notes": [], "created": "2022-01-13T21:01:11.242Z", "modified": "2022-01-13T21:03:34.222Z"}, {"entity": "publication", "iuid": "dee615b15b7b408c8ccef80f93daeed6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dee615b15b7b408c8ccef80f93daeed6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dee615b15b7b408c8ccef80f93daeed6"}}, "title": "Initial impacts of the COVID-19 pandemic on sexual and reproductive health service use and unmet need in Britain: findings from a quasi-representative survey (Natsal-COVID).", "authors": [{"family": "Dema", "given": "Emily", "initials": "E"}, {"family": "Gibbs", "given": "Jo", "initials": "J"}, {"family": "Clifton", "given": "Soazig", "initials": "S"}, {"family": "Copas", "given": "Andrew J", "initials": "AJ"}, {"family": "Tanton", "given": "Clare", "initials": "C"}, {"family": "Riddell", "given": "Julie", "initials": "J"}, {"family": "P\u00e9rez", "given": "Raquel Bos\u00f3", "initials": "RB"}, {"family": "Reid", "given": "David", "initials": "D"}, {"family": "Bonell", "given": "Chris", "initials": "C"}, {"family": "Unemo", "given": "Magnus", "initials": "M"}, {"family": "Mercer", "given": "Catherine H", "initials": "CH"}, {"family": "Mitchell", "given": "Kirstin R", "initials": "KR"}, {"family": "Sonnenberg", "given": "Pam", "initials": "P"}, {"family": "Field", "given": "Nigel", "initials": "N"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "Lancet Public Health", "issn": "2468-2667", "volume": "7", "issue": "1", "pages": "e36-e47", "issn-l": null}, "abstract": "The COVID-19 pandemic has affected sexual and reproductive health (SRH) service use and unmet need, but the impact is unknown. We aimed to determine the proportion of participants reporting sexual risk behaviours, SRH service use and unmet need, and to assess remote sexually transmitted infection (STI) testing service use after the first national lockdown in Britain.\n\nWe used data from the National Surveys of Sexual Attitudes and Lifestyles (Natsal)-COVID cross-sectional, quasi-representative web survey (Natsal-COVID Wave 1). Adults aged 18-59 years who resided in England, Scotland, or Wales completed the survey between July 29 and Aug 10, 2020, which included questions about the approximate 4-month period after announcement of the initial lockdown in Britain (March 23, 2020). Quota-based sampling and weighting were used to achieve a quasi-representative population sample. Participants aged 45-59 years were excluded from services analysis due to low rates of SRH service use. Among individuals aged 18-44 years, we estimated reported SRH service use and inability to access, and calculated age-adjusted odds ratios (aORs) among sexually experienced individuals (those reporting any sexual partner in their lifetime) and sexually active individuals (those reporting any sexual partner in the past year). Unweighted denominators and weighted estimates are presented hereafter.\n\n6654 individuals had complete interviews and were included in the analysis. Among 3758 participants aged 18-44 years, 82\u00b70% reported being sexually experienced, and 73\u00b77% reported being sexually active. 20\u00b78% of sexually experienced participants aged 18-44 years reported using SRH services in the 4-month period. Overall, 9\u00b77% of 3108 participants (9\u00b75% of men; 9\u00b79% of women) reported being unable to use a service they needed, although of the participants who reported trying but not being able to use a SRH service at least once, 76\u00b74% of participants also reported an instance of successful use. 5\u00b79% of 1221 sexually active men and 3\u00b76% of 1560 sexually active women reported use of STI-related services and 14\u00b78% of 1728 sexually experienced women reported use of contraceptive services, with SRH service use highest among individuals aged 18-24 years. Sexually active participants reporting condomless sex with new partners since lockdown were much more likely to report using STI-related services than those who did not report condomless sex (aOR 23\u00b78 [95% CI 11\u00b76-48\u00b79]) for men, 10\u00b75 [3\u00b79-28\u00b72] for women) and, among men, were also more likely to have an unsuccessful attempt at STI-service use (aOR 13\u00b73 [5\u00b73-32\u00b79]). Among 106 individuals who reported using STI testing services, 64\u00b74% accessed services remotely (telephone, video, or online). Among 2581 women aged 25-59 years, 2\u00b74% reported cervical screening compared with an estimated 6% in a comparable 4-month period before the pandemic.\n\nMany people accessed SRH care during the initial lockdown; however, young people and those reporting sexual risk behaviours reported difficulties in accessing services and thus such services might need to address a backlog of need.\n\nWellcome Trust, The Economic and Social Research Council, The National Institute for Health Research, Medical Research Council/Chief Scientist Office and Public Health Sciences Unit, and UCL Coronavirus Response Fund.", "doi": "10.1016/S2468-2667(21)00253-X", "pmid": "34995541", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2468-2667(21)00253-X"}], "notes": [], "created": "2022-01-10T15:31:13.250Z", "modified": "2022-01-10T15:31:13.264Z"}, {"entity": "publication", "iuid": "99ed1321db26492d99260e63ebb3cb29", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/99ed1321db26492d99260e63ebb3cb29.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/99ed1321db26492d99260e63ebb3cb29"}}, "title": "Global Behaviors, Perceptions, and the Emergence of Social Norms at the Onset of the COVID-19 Pandemic.", "authors": [{"family": "Hensel", "given": "Lukas", "initials": "L"}, {"family": "Witte", "given": "Marc", "initials": "M"}, {"family": "Caria", "given": "A Stefano", "initials": "AS"}, {"family": "Fetzer", "given": "Thiemo", "initials": "T"}, {"family": "Fiorin", "given": "Stefano", "initials": "S"}, {"family": "G\u00f6tz", "given": "Friedrich M", "initials": "FM"}, {"family": "Gomez", "given": "Margarita", "initials": "M"}, {"family": "Haushofer", "given": "Johannes", "initials": "J"}, {"family": "Ivchenko", "given": "Andriy", "initials": "A"}, {"family": "Kraft-Todd", "given": "Gordon", "initials": "G"}, {"family": "Reutskaja", "given": "Elena", "initials": "E"}, {"family": "Roth", "given": "Christopher", "initials": "C"}, {"family": "Yoeli", "given": "Erez", "initials": "E"}, {"family": "Jachimowicz", "given": "Jon M", "initials": "JM"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "J Econ Behav Organ", "issn": "0167-2681", "issn-l": null, "volume": "193u", "issue": null, "pages": "473-496"}, "abstract": "We conducted a large-scale survey covering 58 countries and over 100,000 respondents between late March and early April 2020 to study beliefs and attitudes towards citizens' and governments' responses at the onset of the COVID-19 pandemic. Most respondents reported holding normative beliefs in support of COVID-19 containment measures, as well as high rates of adherence to these measures. They also believed that their government and their country's citizens were not doing enough and underestimated the degree to which others in their country supported strong behavioral and policy responses to the pandemic. Normative beliefs were strongly associated with adherence, as well as beliefs about others' and the government's response. Lockdowns were associated with greater optimism about others' and the government's response, and improvements in measures of perceived mental well-being; these effects tended to be larger for those with stronger normative beliefs. Our findings highlight how social norms can arise quickly and effectively to support cooperation at a global scale.", "doi": "10.1016/j.jebo.2021.11.015", "pmid": "34955573", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0167-2681(21)00487-X"}, {"db": "pmc", "key": "PMC8684329"}], "notes": [], "created": "2022-01-04T15:24:43.619Z", "modified": "2022-11-22T05:42:28.273Z"}, {"entity": "publication", "iuid": "7468bf355bed49c5a260c0c5f2d0b6eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7468bf355bed49c5a260c0c5f2d0b6eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7468bf355bed49c5a260c0c5f2d0b6eb"}}, "title": "Correction: Effects of the COVID-19 pandemic on patients with inflammatory joint diseases in Sweden: from infection severity to impact on care provision.", "authors": [], "type": "journal article", "published": "2022-01-00", "journal": {"title": "RMD Open", "issn": "2056-5933", "volume": "8", "issue": "1", "issn-l": null}, "abstract": null, "doi": "10.1136/rmdopen-2021-001987corr1", "pmid": "35042729", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "rmdopen-2021-001987corr1"}, {"db": "pmc", "key": "PMC8783965"}], "notes": [], "created": "2022-01-27T07:07:25.027Z", "modified": "2022-01-27T07:07:25.042Z"}, {"entity": "publication", "iuid": "7a040f43e3654844a378be43affb954b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a040f43e3654844a378be43affb954b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a040f43e3654844a378be43affb954b"}}, "title": "Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.", "authors": [{"family": "Fallerini", "given": "Chiara", "initials": "C"}, {"family": "Picchiotti", "given": "Nicola", "initials": "N"}, {"family": "Baldassarri", "given": "Margherita", "initials": "M"}, {"family": "Zguro", "given": "Kristina", "initials": "K"}, {"family": "Daga", "given": "Sergio", "initials": "S"}, {"family": "Fava", "given": "Francesca", "initials": "F"}, {"family": "Benetti", "given": "Elisa", "initials": "E"}, {"family": "Amitrano", "given": "Sara", "initials": "S"}, {"family": "Bruttini", "given": "Mirella", "initials": "M"}, {"family": "Palmieri", "given": "Maria", "initials": "M"}, {"family": "Croci", "given": "Susanna", "initials": "S"}, {"family": "Lista", "given": "Mirjam", "initials": "M"}, {"family": "Beligni", "given": "Giada", "initials": "G"}, {"family": "Valentino", "given": "Floriana", "initials": "F"}, {"family": "Meloni", "given": "Ilaria", "initials": "I"}, {"family": "Tanfoni", "given": "Marco", "initials": "M"}, {"family": "Minnai", "given": "Francesca", "initials": "F"}, {"family": "Colombo", "given": "Francesca", "initials": "F"}, {"family": "Cabri", "given": "Enrico", "initials": "E"}, {"family": "Fratelli", "given": "Maddalena", "initials": "M"}, {"family": "Gabbi", "given": "Chiara", "initials": "C"}, {"family": "Mantovani", "given": "Stefania", "initials": "S"}, {"family": "Frullanti", "given": "Elisa", "initials": "E"}, {"family": "Gori", "given": "Marco", "initials": "M"}, {"family": "Crawley", "given": "Francis P", "initials": "FP"}, {"family": "Butler-Laporte", "given": "Guillaume", "initials": "G"}, {"family": "Richards", "given": "Brent", "initials": "B"}, {"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Ludwig", "given": "Kerstin U", "initials": "KU"}, {"family": "Schulte", "given": "Eva C", "initials": "EC"}, {"family": "Pairo-Castineira", "given": "Erola", "initials": "E"}, {"family": "Baillie", "given": "John Kenneth", "initials": "JK"}, {"family": "Schmidt", "given": "Axel", "initials": "A"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "WES/WGS Working Group Within the HGI", "given": "", "initials": ""}, {"family": "GenOMICC Consortium", "given": "", "initials": ""}, {"family": "GEN-COVID Multicenter Study", "given": "", "initials": ""}, {"family": "Mari", "given": "Francesca", "initials": "F"}, {"family": "Renieri", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-0846-9220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6388ba45f89d4c3b94c4c6c88f97cadb.json"}}, {"family": "Furini", "given": "Simone", "initials": "S"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "Hum Genet", "issn": "0340-6717", "issn-l": null, "volume": "141", "issue": "1", "pages": "147-173"}, "abstract": "The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management.", "doi": "10.1007/s00439-021-02397-7", "pmid": "34889978", "labels": {"Type: Journal article": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pmc", "key": "PMC8661833"}, {"db": "pii", "key": "10.1007/s00439-021-02397-7"}], "notes": [], "created": "2021-12-12T06:48:31.290Z", "modified": "2023-07-13T11:31:18.816Z"}, {"entity": "publication", "iuid": "bd9e593ee2964a518247d66165ff1c1e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bd9e593ee2964a518247d66165ff1c1e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bd9e593ee2964a518247d66165ff1c1e"}}, "title": "Associations of pre-pandemic levels of physical function and physical activity with COVID-19-like symptoms during the outbreak.", "authors": [{"family": "Saadeh", "given": "Marguerita", "initials": "M", "orcid": "0000-0002-2689-5784", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/324dbc9ae7ec4e5daab17e7fab6a183c.json"}}, {"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A"}, {"family": "Vetrano", "given": "Davide Liborio", "initials": "DL"}, {"family": "von Rosen", "given": "Philip", "initials": "P"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Welmer", "given": "Anna-Karin", "initials": "AK"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "Aging Clin Exp Res", "issn": "1720-8319", "volume": "34", "issue": "1", "pages": "235-247", "issn-l": "1594-0667"}, "abstract": "One's physical function and physical activity levels can predispose or protect from the development of respiratory infections. We aimed to explore the associations between pre-pandemic levels of physical function and physical activity and the development of COVID-19-like symptoms in Swedish older adults.\n\nWe analyzed data from 904 individuals aged \u2265 68 years from the population-based Swedish National study on Aging and Care in Kungsholmen. COVID-19-like symptoms were assessed by phone interview (March-June 2020) and included fever, cough, sore throat and/or a cold, headache, pain in muscles, legs and joints, loss of taste and/or odor, breathing difficulties, chest pain, gastrointestinal symptoms, and eye inflammation. Muscle strength, mobility, and physical activity were examined in 2016-2018 by objective testing. Data were analyzed using logistic regression models in the total sample and stratifying by age.\n\nDuring the first outbreak of the pandemic, 325 (36%) individuals from our sample developed COVID-19-like symptoms. Those with slower performance in the chair stand test had an odds ratio (OR) of 1.5 (95% confidence interval [CI] 1.1-2.1) for presenting with COVID-19-like symptoms compared to better performers, after adjusting for potential confounders. The association was even higher among people aged \u2265 80 years (OR 2.6; 95% CI 1.5-4.7). No significant associations were found between walking speed or engagement in moderate-to-vigorous physical activity and the likelihood to develop COVID-19-like symptoms.\n\nPoor muscle strength, a possible indicator of frailty, may predispose older adults to higher odds of developing COVID-19-like symptoms, especially among the oldest-old.", "doi": "10.1007/s40520-021-02006-7", "pmid": "34716912", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8556821"}, {"db": "pii", "key": "10.1007/s40520-021-02006-7"}], "notes": [], "created": "2021-11-01T19:52:53.543Z", "modified": "2023-06-19T15:29:59.121Z"}, {"entity": "publication", "iuid": "4d20e161965b43b89cd46cf341eab89c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4d20e161965b43b89cd46cf341eab89c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4d20e161965b43b89cd46cf341eab89c"}}, "title": "Association between first language and SARS-CoV-2 infection rates, hospitalization, intensive care admissions and death in Finland: a population-based observational cohort study.", "authors": [{"family": "Holmberg", "given": "Ville", "initials": "V"}, {"family": "Salmi", "given": "Heli", "initials": "H"}, {"family": "Kattainen", "given": "Salla", "initials": "S"}, {"family": "Ollgren", "given": "Jukka", "initials": "J"}, {"family": "Kantele", "given": "Anu", "initials": "A"}, {"family": "Pynn\u00f6nen", "given": "Juulia", "initials": "J"}, {"family": "J\u00e4rvinen", "given": "Asko", "initials": "A"}, {"family": "Forsblom", "given": "Erik", "initials": "E"}, {"family": "Sil\u00e9n", "given": "Suvi", "initials": "S"}, {"family": "Kivivuori", "given": "Sanna-Maria", "initials": "SM"}, {"family": "Meretoja", "given": "Atte", "initials": "A"}, {"family": "H\u00e4stbacka", "given": "Johanna", "initials": "J"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "Clin Microbiol Infect", "issn": "1469-0691", "volume": "28", "issue": "1", "pages": "107-113", "issn-l": null}, "abstract": "Motivated by reports of increased risk of coronavirus disease 2019 (COVID-19) in ethnic minorities of high-income countries, we explored whether patients with a foreign first language are at an increased risk of COVID-19 infections, more serious presentations, or worse outcomes.\n\nIn a retrospective observational population-based quality registry study covering a population of 1.7 million, we studied the incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), admissions to specialist healthcare and the intensive care unit (ICU), and all-cause case fatality in different language groups between 27th February and 3rd August 2020 in Southern Finland. A first language other than Finnish, Swedish or S\u00e1mi served as a surrogate marker for a foreign ethnic background.\n\nIn total, 124 240 individuals were tested, and among the 118 300 (95%) whose first language could be determined, 4005 (3.4%) were COVID-19-positive, 623 (0.5%) were admitted to specialized hospitals, and 147 (0.1%) were admitted to the ICU; 254 (0.2%) died. Those with a foreign first language had lower testing rates (348, 95%CI 340-355 versus 758, 95%CI 753-762 per 10 000, p < 0.0001), higher incidence (36, 95%CI 33-38 versus 22, 95%CI 21-23 per 10 000, p < 0.0001), and higher positivity rates (103, 95%CI 96-109 versus 29, 95%CI 28-30 per 1000, p < 0.0001). There was no significant difference in ICU admissions, disease severity at ICU admission, or ICU outcomes. Case fatality by 90 days was 7.7% in domestic cases and 1.2% in those with a foreign first language, explained by demographics (age- and sex-adjusted HR 0.49, 95%CI 0.21-1.15).\n\nThe population with a foreign first language was at an increased risk for testing positive for SARS-CoV-2, but when hospitalized they had outcomes similar to those in the native, domestic language population. This suggests that special attention should be paid to the prevention and control of infectious diseases among language minorities.", "doi": "10.1016/j.cmi.2021.08.022", "pmid": "34949510", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(21)00484-5"}, {"db": "pmc", "key": "PMC8482016"}], "notes": [], "created": "2022-01-04T15:29:14.195Z", "modified": "2022-01-04T15:29:14.219Z"}, {"entity": "publication", "iuid": "a2842bb0d7a54c41838a25b1708d64d2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2842bb0d7a54c41838a25b1708d64d2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2842bb0d7a54c41838a25b1708d64d2"}}, "title": "Characterizing Post-COVID Syndrome in Outpatient and Inpatient Setting in Sweden Using Diagnosis Codes - A Nationwide Observational Cohort and Matched Cohort Study", "authors": [{"family": "Ollila", "given": "Hanna M", "initials": "HM"}, {"family": "Fonseca", "given": "Osvaldo", "initials": "O"}, {"family": "Caspersen", "given": "Ida Henriette", "initials": "IH"}, {"family": "Kalucza", "given": "Sebastian", "initials": "S"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Trogstad", "given": "Lill", "initials": "L"}, {"family": "Magnus", "given": "Per", "initials": "P"}, {"family": "Hulvej Rod", "given": "Naja", "initials": "N"}, {"family": "Ganna", "given": "Andrea", "initials": "A"}, {"family": "Eriksson", "given": "Marie", "initials": "M"}, {"family": "Fors Connolly", "given": "Anne Marie", "initials": "AM"}], "type": "journal-article", "published": "2022-00-00", "journal": {"title": "SSRN Journal", "issn": "1556-5068", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.2139/ssrn.4276607", "pmid": null, "labels": {"Research Area: Vaccine": null, "Type: Preprint": null, "Category: Health": null, "Topics: Register-based research": null, "Category: Post-COVID": null}, "xrefs": [], "notes": [], "created": "2022-11-29T08:49:10.019Z", "modified": "2022-11-29T09:29:28.220Z"}, {"entity": "publication", "iuid": "5d991aa79d974f8fad60017f9324ba52", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d991aa79d974f8fad60017f9324ba52.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d991aa79d974f8fad60017f9324ba52"}}, "title": "Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges.", "authors": [{"family": "Masterson", "given": "C H", "initials": "CH"}, {"family": "Ceccato", "given": "A", "initials": "A"}, {"family": "Artigas", "given": "A", "initials": "A"}, {"family": "Dos Santos", "given": "C", "initials": "C"}, {"family": "Rocco", "given": "P R", "initials": "PR"}, {"family": "Rolandsson Enes", "given": "S", "initials": "S"}, {"family": "Weiss", "given": "D J", "initials": "DJ"}, {"family": "McAuley", "given": "D", "initials": "D"}, {"family": "Matthay", "given": "M A", "initials": "MA"}, {"family": "English", "given": "K", "initials": "K"}, {"family": "Curley", "given": "G F", "initials": "GF"}, {"family": "Laffey", "given": "J G", "initials": "JG", "orcid": "0000-0002-1246-9573", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9ea7776786048ec82a309a61925d42d.json"}}], "type": "journal article", "published": "2021-12-31", "journal": {"title": "Intensive Care Med Exp", "issn": "2197-425X", "volume": "9", "issue": "1", "pages": "61", "issn-l": null}, "abstract": "Severe viral pneumonia is a significant cause of morbidity and mortality globally, whether due to outbreaks of endemic viruses, periodic viral epidemics, or the rarer but devastating global viral pandemics. While limited anti-viral therapies exist, there is a paucity of direct therapies to directly attenuate viral pneumonia-induced lung injury, and management therefore remains largely supportive. Mesenchymal stromal/stem cells (MSCs) are receiving considerable attention as a cytotherapeutic for viral pneumonia. Several properties of MSCs position them as a promising therapeutic strategy for viral pneumonia-induced lung injury as demonstrated in pre-clinical studies in relevant models. More recently, early phase clinical studies have demonstrated a reassuring safety profile of these cells. These investigations have taken on an added importance and urgency during the COVID-19 pandemic, with multiple trials in progress across the globe. In parallel with clinical translation, strategies are being investigated to enhance the therapeutic potential of these cells in vivo, with different MSC tissue sources, specific cellular products including cell-free options, and strategies to 'licence' or 'pre-activate' these cells, all being explored. This review will assess the therapeutic potential of MSC-based therapies for severe viral pneumonia. It will describe the aetiology and epidemiology of severe viral pneumonia, describe current therapeutic approaches, and examine the data suggesting therapeutic potential of MSCs for severe viral pneumonia in pre-clinical and clinical studies. The challenges and opportunities for MSC-based therapies will then be considered.", "doi": "10.1186/s40635-021-00424-5", "pmid": "34970706", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s40635-021-00424-5"}], "notes": [], "created": "2022-01-04T14:58:20.132Z", "modified": "2022-01-04T14:58:20.209Z"}, {"entity": "publication", "iuid": "2f28263688924fa99d560148ba0d0bec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2f28263688924fa99d560148ba0d0bec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2f28263688924fa99d560148ba0d0bec"}}, "title": "Identifying Risk of Adverse Outcomes in COVID-19 Patients via Artificial Intelligence-Powered Analysis of 12-Lead Intake Electrocardiogram.", "authors": [{"family": "Sridhar", "given": "Arun R", "initials": "AR"}, {"family": "Chen", "given": "Zih-Hua", "initials": "ZH"}, {"family": "Mayfield", "given": "Jacob J", "initials": "JJ"}, {"family": "Fohner", "given": "Alison E", "initials": "AE"}, {"family": "Arvanitis", "given": "Panagiotis", "initials": "P"}, {"family": "Atkinson", "given": "Sarah", "initials": "S"}, {"family": "Braunschweig", "given": "Frieder", "initials": "F"}, {"family": "Chatterjee", "given": "Neal A", "initials": "NA"}, {"family": "Zamponi", "given": "Alessio Falasca", "initials": "AF"}, {"family": "Johnson", "given": "Gregory", "initials": "G"}, {"family": "Joshi", "given": "Sanika A", "initials": "SA"}, {"family": "Lassen", "given": "Mats C H", "initials": "MCH"}, {"family": "Poole", "given": "Jeanne E", "initials": "JE"}, {"family": "Rumer", "given": "Christopher", "initials": "C"}, {"family": "Skaarup", "given": "Kristoffer G", "initials": "KG"}, {"family": "Biering-S\u00f8rensen", "given": "Tor", "initials": "T"}, {"family": "Blomstrom-Lundqvist", "given": "Carina", "initials": "C"}, {"family": "Linde", "given": "Cecilia M", "initials": "CM"}, {"family": "Maleckar", "given": "Mary M", "initials": "MM"}, {"family": "Boyle", "given": "Patrick M", "initials": "PM"}], "type": "journal article", "published": "2021-12-31", "journal": {"title": "Cardiovasc Digit Health J", "issn": "2666-6936", "issn-l": null}, "abstract": "Adverse events in COVID-19 are difficult to predict. Risk stratification is encumbered by the need to protect healthcare workers. We hypothesize that AI can help identify subtle signs of myocardial involvement in the 12-lead electrocardiogram (ECG), which could help predict complications.\n\nUse intake ECGs from COVID-19 patients to train AI models to predict risk of mortality or major adverse cardiovascular events (MACE).\n\nWe studied intake ECGs from 1448 COVID-19 patients (60.5% male, 63.4\u00b116.9 years). Records were labeled by mortality (death vs. discharge) or MACE (no events vs. arrhythmic, heart failure [HF], or thromboembolic [TE] events), then used to train AI models; these were compared to conventional regression models developed using demographic and comorbidity data.\n\n245 (17.7%) patients died (67.3% male, 74.5\u00b114.4 years); 352 (24.4%) experienced at least one MACE (119 arrhythmic; 107 HF; 130 TE). AI models predicted mortality and MACE with area under the curve (AUC) values of 0.60\u00b10.05 and 0.55\u00b10.07, respectively; these were comparable to AUC values for conventional models (0.73\u00b10.07 and 0.65\u00b10.10). There were no prominent temporal trends in mortality rate or MACE incidence in our cohort; holdout testing with data from after a cutoff date (June 9, 2020) did not degrade model performance.\n\nUsing intake ECGs alone, our AI models had limited ability to predict hospitalized COVID-19 patients' risk of mortality or MACE. Our models' accuracy was comparable to that of conventional models built using more in-depth information, but translation to clinical use would require higher sensitivity and positive predictive value. In the future, we hope that mixed-input AI models utilizing both ECG and clinical data may be developed to enhance predictive accuracy.", "doi": "10.1016/j.cvdhj.2021.12.003", "pmid": "35005676", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2666-6936(21)00146-8"}, {"db": "pmc", "key": "PMC8719367"}], "notes": [], "created": "2022-01-13T21:10:16.886Z", "modified": "2022-01-13T21:10:16.926Z"}, {"entity": "publication", "iuid": "0d6ab44032aa4e2780a6e8133916cf4e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d6ab44032aa4e2780a6e8133916cf4e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d6ab44032aa4e2780a6e8133916cf4e"}}, "title": "Baseline knowledge and attitudes on COVID-19 among hotels' staff: A cross-sectional study in Kigali, Rwanda.", "authors": [{"family": "Hagabimana", "given": "Aphrodis", "initials": "A", "orcid": "0000-0003-3658-4020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a791da28dc4401180cf45fe59ed2b8b.json"}}, {"family": "Omolo", "given": "Jared", "initials": "J"}, {"family": "El-Khatib", "given": "Ziad", "initials": "Z"}, {"family": "Rwagasore", "given": "Edson", "initials": "E"}, {"family": "Benemariya", "given": "Noella", "initials": "N"}, {"family": "Nsekuye", "given": "Olivier", "initials": "O"}, {"family": "Kabeja", "given": "Adeline", "initials": "A"}, {"family": "Balisanga", "given": "Helene", "initials": "H"}, {"family": "Umutoni", "given": "Angela", "initials": "A"}, {"family": "Musafili", "given": "Aimable", "initials": "A"}, {"family": "Ndagijimana", "given": "Albert", "initials": "A"}], "type": "journal article", "published": "2021-12-31", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "12", "pages": "e0261744", "issn-l": "1932-6203"}, "abstract": "The World Health Organization declared coronavirus disease 2019 (COVID-19) as a global pandemic on the 11th of March, 2020. Hotels and other public establishments have been associated with higher transmission rates. Sensitisation of staff and strengthening of Infection Prevention and Control (IPC) practices in such settings are important interventions. This study assessed the baseline knowledge and attitudes on COVID-19 among hotels' representatives in Kigali, Rwanda.\n\nA cross-sectional study was conducted among hotels' staff in Kigali in July 2020. A structured questionnaire was self-administered to 104 participants. Baseline knowledge and attitudes were assessed using a number of pre-test questions and mean scores were used to dichotomise the participants' responses as satisfactory or unsatisfactory.\n\nAll of the 104 hotels' staff completed the self-administered questionnaires. Sixty-seven percent (n = 70) were male and 58% (n = 60) were aged between 30 and 44 years. The satisfactory rate of correct answers was 63%\u00b12.4 (n = 66) on knowledge and 68%\u00b11.7 (n = 71) on attitudes evaluation. Participants with University education were more likely to have satisfactory knowledge (AOR: 2.6, 95% C.I: 1.07-6.58) than those with secondary education or less. The staff working in the front-office (AOR: 0.05; 95% CI 0.01-0.54) and housekeeping (AOR: 0.09; 95% C.I: 0.01-0.87) were less likely to have satisfactory attitudes than those working in the administration.\n\nHotels' staff based in the capital of Rwanda have shown satisfactory knowledge and attitudes regarding appropriate IPC practices for preventing the COVID-19 transmission. Educational interventions are needed to improve their knowledge and attitudes for better prevention in this setting.", "doi": "10.1371/journal.pone.0261744", "pmid": "34972131", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-30529"}], "notes": [], "created": "2022-01-04T14:57:44.192Z", "modified": "2022-01-04T14:57:44.255Z"}, {"entity": "publication", "iuid": "2249183c14434629ab13489a5ec18ac4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2249183c14434629ab13489a5ec18ac4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2249183c14434629ab13489a5ec18ac4"}}, "title": "A cohort study of the effect of SARS-CoV-2 point of care rapid RT-PCR at the Emergency Department on targeted admission", "authors": [{"family": "Mortazavi", "given": "Susanne E", "initials": "SE"}, {"family": "Inghammar", "given": "Malin", "initials": "M"}, {"family": "Christiansen", "given": "Claus", "initials": "C"}, {"family": "Pesola", "given": "Anne Katrine", "initials": "AK"}, {"family": "Stenkilsson", "given": "Mikael", "initials": "M"}, {"family": "Paulsson", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1104-2727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0e37d2d03f64fe78a0e84f53922d29f.json"}}], "type": "posted-content", "published": "2021-12-31", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.12.29.21268501", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:42:04.720Z", "modified": "2022-01-04T15:42:04.767Z"}, {"entity": "publication", "iuid": "e4ca08d68b2545e686009a01d2c3b963", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e4ca08d68b2545e686009a01d2c3b963.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e4ca08d68b2545e686009a01d2c3b963"}}, "title": "Toothbrush as a sampling methodology for detection of SARS- CoV-2.", "authors": [{"family": "Gupta", "given": "Shipra", "initials": "S", "orcid": "0000-0003-2097-2459", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa6dd4cea3824827b3ead550b8267b2a.json"}}, {"family": "Mohindra", "given": "Ritin", "initials": "R"}, {"family": "Jain", "given": "Akanksha", "initials": "A"}, {"family": "Singla", "given": "Mohita", "initials": "M"}, {"family": "Sorsa", "given": "Timo", "initials": "T"}, {"family": "R\u00e4is\u00e4nen", "given": "Ismo", "initials": "I", "orcid": "0000-0001-5821-5299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5688183e182e4194888dc98301077bab.json"}}, {"family": "Malhotra", "given": "Meenakshi", "initials": "M"}, {"family": "Soni", "given": "Roop Kishor", "initials": "RK"}, {"family": "Kumar", "given": "Amit", "initials": "A"}, {"family": "Kanta", "given": "Poonam", "initials": "P"}, {"family": "Gauba", "given": "Krishan", "initials": "K"}, {"family": "Singh", "given": "Mini P", "initials": "MP"}, {"family": "Ghosh", "given": "Arnab", "initials": "A"}, {"family": "Suri", "given": "Vikas", "initials": "V"}], "type": "letter", "published": "2021-12-30", "journal": {"title": "Oral Dis", "issn": "1601-0825", "issn-l": null}, "abstract": null, "doi": "10.1111/odi.14122", "pmid": "34967494", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T14:59:04.321Z", "modified": "2022-01-04T14:59:04.366Z"}, {"entity": "publication", "iuid": "c68e747b1b914f13a00ff1399358cd10", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c68e747b1b914f13a00ff1399358cd10.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c68e747b1b914f13a00ff1399358cd10"}}, "title": "Experiences of Stress - A Focus Group Interview Study Among Swedish Adolescents During the COVID-19 Pandemic.", "authors": [{"family": "H\u00f6rbo", "given": "Moa", "initials": "M"}, {"family": "Johansson", "given": "Camilla", "initials": "C"}, {"family": "Garnow", "given": "Tide", "initials": "T"}, {"family": "Garmy", "given": "Pernilla", "initials": "P", "orcid": "0000-0003-1643-0171", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc4733a9e87a42fea6e7a7323feb61b3.json"}}, {"family": "Einberg", "given": "Eva-Lena", "initials": "EL", "orcid": "0000-0002-5586-3810", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d67e636861d492fb682ec1601422cd0.json"}}], "type": "journal article", "published": "2021-12-30", "journal": {"title": "J Sch Nurs", "issn": "1546-8364", "pages": "10598405211071002", "issn-l": null}, "abstract": "Adolescence can be a stressful period in life. The period contains challenges associated with the transition from childhood to adulthood (body changes, changes in interpersonal relationships, and identity changes). The aim was to investigate experiences of stress among adolescents in addition to stress related to the COVID-19 pandemic. Focus group interviews (n = 8) were conducted with girls (n = 22) and boys (n = 19) aged 13-15 in southern Sweden. The transcribed interviews were analyzed with qualitative content analysis. Analysis of the collected material resulted in two categories with four sub-categories each of which highlights adolescents' experiences of stress. The results show that adolescents' have a variety of experiences of stress, i.e., what they mean are the sources of stress and how stress is manifested. The adolescents experienced how stress was manifested both physically and emotionally. This affected both their sleep and performance. The adolescents reflected on both positive and negative manifestations of stress.", "doi": "10.1177/10598405211071002", "pmid": "34967254", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T14:59:47.820Z", "modified": "2022-01-04T14:59:47.935Z"}, {"entity": "publication", "iuid": "cd00b8efc485401f883f70b7c92aeb11", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd00b8efc485401f883f70b7c92aeb11.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd00b8efc485401f883f70b7c92aeb11"}}, "title": "The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males.", "authors": [{"family": "Croci", "given": "Susanna", "initials": "S"}, {"family": "Venneri", "given": "Mary Anna", "initials": "MA"}, {"family": "Mantovani", "given": "Stefania", "initials": "S"}, {"family": "Fallerini", "given": "Chiara", "initials": "C"}, {"family": "Benetti", "given": "Elisa", "initials": "E"}, {"family": "Picchiotti", "given": "Nicola", "initials": "N"}, {"family": "Campolo", "given": "Federica", "initials": "F"}, {"family": "Imperatore", "given": "Francesco", "initials": "F"}, {"family": "Palmieri", "given": "Maria", "initials": "M"}, {"family": "Daga", "given": "Sergio", "initials": "S"}, {"family": "Gabbi", "given": "Chiara", "initials": "C"}, {"family": "Montagnani", "given": "Francesca", "initials": "F"}, {"family": "Beligni", "given": "Giada", "initials": "G"}, {"family": "Farias", "given": "Ticiana D J", "initials": "TDJ"}, {"family": "Carriero", "given": "Miriam Lucia", "initials": "ML"}, {"family": "Di Sarno", "given": "Laura", "initials": "L"}, {"family": "Alaverdian", "given": "Diana", "initials": "D"}, {"family": "Aslaksen", "given": "Sigrid", "initials": "S"}, {"family": "Cubellis", "given": "Maria Vittoria", "initials": "MV"}, {"family": "Spiga", "given": "Ottavia", "initials": "O", "orcid": "0000-0002-0263-7107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc173dee23db417c8875e9c9c8f9125b.json"}}, {"family": "Baldassarri", "given": "Margherita", "initials": "M"}, {"family": "Fava", "given": "Francesca", "initials": "F"}, {"family": "Norman", "given": "Paul J", "initials": "PJ"}, {"family": "Frullanti", "given": "Elisa", "initials": "E"}, {"family": "Isidori", "given": "Andrea M", "initials": "AM", "orcid": "0000-0002-9037-5417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d1bed69cf714996b0a64db788a882f5.json"}}, {"family": "Amoroso", "given": "Antonio", "initials": "A"}, {"family": "Mari", "given": "Francesca", "initials": "F"}, {"family": "Furini", "given": "Simone", "initials": "S"}, {"family": "Mondelli", "given": "Mario U", "initials": "MU"}, {"family": "Chiariello", "given": "Mario", "initials": "M"}, {"family": "Renieri", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-0846-9220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6388ba45f89d4c3b94c4c6c88f97cadb.json"}}, {"family": "Meloni", "given": "Ilaria", "initials": "I"}], "type": "journal article", "published": "2021-12-29", "journal": {"title": "Autophagy", "issn": "1554-8635", "pages": "1-11", "issn-l": null}, "abstract": "The polymorphism L412F in TLR3 has been associated with several infectious diseases. However, the mechanism underlying this association is still unexplored. Here, we show that the L412F polymorphism in TLR3 is a marker of severity in COVID-19. This association increases in the sub-cohort of males. Impaired macroautophagy/autophagy and reduced TNF/TNF\u03b1 production was demonstrated in HEK293 cells transfected with TLR3L412F-encoding plasmid and stimulated with specific agonist poly(I:C). A statistically significant reduced survival at 28 days was shown in L412F COVID-19 patients treated with the autophagy-inhibitor hydroxychloroquine (p = 0.038). An increased frequency of autoimmune disorders such as co-morbidity was found in L412F COVID-19 males with specific class II HLA haplotypes prone to autoantigen presentation. Our analyses indicate that L412F polymorphism makes males at risk of severe COVID-19 and provides a rationale for reinterpreting clinical trials considering autophagy pathways.Abbreviations: AP: autophagosome; AUC: area under the curve; BafA1: bafilomycin A1; COVID-19: coronavirus disease-2019; HCQ: hydroxychloroquine; RAP: rapamycin; ROC: receiver operating characteristic; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2; TLR: toll like receptor; TNF/TNF-\u03b1: tumor necrosis factor.", "doi": "10.1080/15548627.2021.1995152", "pmid": "34964709", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:01:02.575Z", "modified": "2022-01-04T15:01:02.690Z"}, {"entity": "publication", "iuid": "d84e2dd02797453f8032f1c41fa1d769", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d84e2dd02797453f8032f1c41fa1d769.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d84e2dd02797453f8032f1c41fa1d769"}}, "title": "Fear of COVID-19, compliance with recommendations against virus transmission, and attitudes towards vaccination in Sweden.", "authors": [{"family": "H\u00e5kansson", "given": "A", "initials": "A"}, {"family": "Claesdotter", "given": "E", "initials": "E"}], "type": "journal article", "published": "2021-12-29", "journal": {"title": "Heliyon", "issn": "2405-8440", "pages": "e08699", "issn-l": null}, "abstract": "Following the immense impact of the COVID-19 pandemic on health and everyday lives world-wide, people's fear of COVID-19 has been studied in a number of settings using the Fear of COVID scale. In Sweden, virus-preventing strategies have differed from comparable countries, with low use of formal lock-down procedures. It is crucial to study correlates of non-compliance with COVID-19 recommendations, and unwillingness to become vaccinated. This study aims to study whether fear of COVID is associated with mental distress and attitudes towards the pandemic, and to study correlates of non-compliance with key anti-COVID recommendations and with reluctancy to vaccination. This anonymous online survey study in web panel participants (N=1,501) aimed to study a range of behavioral changes during COVID-19. Recommendations and vaccinations reluctancy were analyzed in logistic regressions against socio-demographic data, COVID-19 status, and mental health history. Internal consistency of the Fear of COVID scale was calculated. The Fear of COVID scale had a satisfactory internal consistency (Cronbach-alpha 0.84), and was significantly associated with compliance with all COVID-19 recommendations and with mental health. Non-compliance with recommendations was associated with low fear of disease and younger age, among other variables. Being against vaccination was associated, among other variables, with low fear of disease and with low education. In conclusion, the Fear of COVID scale appears to be associated with key attitudes towards the COVID-19 disease. Anti-virus strategies may need to promote compliance with recommendations in subgroups who feel low fear of disease or who believe not to be in a risk group for severe disease.", "doi": "10.1016/j.heliyon.2021.e08699", "pmid": "34981036", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)02802-4"}, {"db": "pmc", "key": "PMC8716143"}], "notes": [], "created": "2022-01-10T15:42:41.325Z", "modified": "2022-01-10T15:42:41.337Z"}, {"entity": "publication", "iuid": "694fdd8ecb754578a81e168adc034800", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/694fdd8ecb754578a81e168adc034800.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/694fdd8ecb754578a81e168adc034800"}}, "title": "Effect of Previous SARS-CoV-2 Infection on Antibody Response to a Single Immunization with the Pfizer BNT162b mRNA Vaccine Among Healthcare Workers in Foggia, Italy.", "authors": [{"family": "Homan", "given": "Tobias", "initials": "T"}, {"family": "Fortunato", "given": "Francesca", "initials": "F"}, {"family": "Corso", "given": "Gaetano", "initials": "G"}, {"family": "Lopalco", "given": "Pier Luigi", "initials": "PL"}, {"family": "Prato", "given": "Rosa", "initials": "R"}, {"family": "Martinelli", "given": "Domenico", "initials": "D", "orcid": "0000-0001-8028-3167", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84b47c38792d47a39a6ca9ff9d38f502.json"}}], "type": "journal article", "published": "2021-12-29", "journal": {"title": "Infect Dis Ther", "issn": "2193-8229", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Data have suggested that SARS-CoV-2 infection causes an antibody response at least as strong as one BNT162b2 vaccine dose. Nevertheless, some aspects require further investigation to better understand the immunogenicity of one vaccine dose among infected individuals. Thus, we evaluated how previous SARS-CoV-2 infection may influence the humoral immunity after a single Pfizer BNT162b mRNA vaccine dose in a sample of healthcare workers (HCWs).\n\nAs part of the routine surveillance activity conducted among HCWs of the Policlinico Riuniti Foggia Hospital (Apulia region, Italy), we conducted a retrospective serosurvey in the period January-March 2021. We compared specific antibody titres (anti-spike IgGs measured by enzyme-linked immunoassay, ELISA) after SARS-CoV-2 infection and after the first dose of the BNT162b2 vaccine, analysing the impact of sex, age, time since infection, and presence of symptoms on the humoral response.\n\nWe included in the study 58 HCWs (mean age 44.1 years, 48.2% male) with anti-spike IgG titres available before and after the first BNT162b2 vaccine dose. Among these, we observed higher titres in previously infected cases (N = 21) than in COVID-19-na\u00efve subjects (N = 37) (medians 1510 vs. 0.68; p < 0.001). A statistically significant difference in anti-spike IgG titres was also observed among previously infected HCWs before vaccine dose in comparison with post-dose infection-na\u00efve HCWs (medians 18.37 vs. 0.68, p < 0.001). Among infected individuals, no differences by sex, age, or time since infection were reported (p > 0.05). Post-dose titres of symptomatic and asymptomatic infected HCWs slightly differed (medians = 1900 vs. 1090; p = 0.048).\n\nOur data support the viable hypothesis of a single-dose vaccine regimen in individuals with a history of COVID-19, but no conclusion on duration of protection in this group can be drawn from our study.", "doi": "10.1007/s40121-021-00582-9", "pmid": "34964938", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40121-021-00582-9"}, {"db": "pmc", "key": "PMC8715151"}], "notes": [], "created": "2022-01-04T15:00:03.072Z", "modified": "2022-01-04T15:00:42.340Z"}, {"entity": "publication", "iuid": "8b6f545f64ee4f3b9bf47069406c68a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b6f545f64ee4f3b9bf47069406c68a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b6f545f64ee4f3b9bf47069406c68a2"}}, "title": "Biosensor-Enabled Deconvolution of the Avidity-Induced Affinity Enhancement for the SARS-CoV-2 Spike Protein and ACE2 Interaction.", "authors": [{"family": "Gutgsell", "given": "Aspen Rene", "initials": "AR"}, {"family": "Gunnarsson", "given": "Anders", "initials": "A"}, {"family": "Forss\u00e9n", "given": "Patrik", "initials": "P"}, {"family": "Gordon", "given": "Euan", "initials": "E"}, {"family": "Fornstedt", "given": "Torgny", "initials": "T", "orcid": "0000-0002-7123-2066", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53811bd2e7764434b2482324fc9cade9.json"}}, {"family": "Geschwindner", "given": "Stefan", "initials": "S", "orcid": "0000-0002-2154-8345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36d7770aaccf4324a28dc5166afb5eeb.json"}}], "type": "journal article", "published": "2021-12-29", "journal": {"title": "Anal Chem", "issn": "1520-6882", "issn-l": null}, "abstract": "Avidity is an effective and frequent phenomenon employed by nature to achieve extremely high-affinity interactions. As more drug discovery efforts aim to disrupt protein-protein interactions, it is becoming increasingly common to encounter systems that utilize avidity effects and to study these systems using surface-based technologies, such as surface plasmon resonance (SPR) or biolayer interferometry. However, heterogeneity introduced from multivalent binding interactions complicates the analysis of the resulting sensorgram. A frequently applied practice is to fit the data based on a 1:1 binding model, and if the fit does not describe the data adequately, then the experimental setup is changed to favor a 1:1 binding interaction. This reductionistic approach is informative but not always biologically relevant. Therefore, we aimed to develop an SPR-based assay that would reduce the heterogeneity to enable the determination of the kinetic rate constants for multivalent binding interactions using the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and the human receptor angiotensin-converting enzyme 2 (ACE2) as a model system. We employed a combinatorial approach to generate a sensor surface that could distinguish between monovalent and multivalent interactions. Using advanced data analysis algorithms to analyze the resulting sensorgrams, we found that controlling the surface heterogeneity enabled the deconvolution of the avidity-induced affinity enhancement for the SARS-CoV-2 spike protein and ACE2 interaction.", "doi": "10.1021/acs.analchem.1c04372", "pmid": "34964599", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:01:21.322Z", "modified": "2022-01-04T15:10:01.638Z"}, {"entity": "publication", "iuid": "ff01ddd3a9c243118b711c0d1af77ad4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff01ddd3a9c243118b711c0d1af77ad4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff01ddd3a9c243118b711c0d1af77ad4"}}, "title": "A hot topic at the environment-health nexus: Investigating the impact of climate change on infectious diseases.", "authors": [{"family": "Grobusch", "given": "Lena C", "initials": "LC"}, {"family": "Grobusch", "given": "Martin P", "initials": "MP"}], "type": "journal article", "published": "2021-12-29", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712"}, "abstract": "COVID-19 pandemic aside, climate change is the ultimate challenge of our time. However, to date, there has been insufficient political thrust to make that much-needed climate action a reality.\n\nInfectious diseases represent only one facet of the threats arising from climate change. Direct impacts from climate change include the more frequent occurrence and increased magnitude of extreme weather events, as well as changing temperatures and precipitation patterns. For climate-sensitive infectious diseases, these changes implicate a shift in geographic and temporal distribution, seasonality, and transmission intensity.\n\nSusceptibility to deleterious effects of climate change is a net result not only of the interplay of environmental factors but also governed by human, societal, and economic factors, with social inequalities being a major determinant of vulnerability. The global South is already disproportionately affected by the climate crisis. The financial capacity to pursue adaptation options is also limited and unevenly distributed.\n\nClimate change-induced mortality and morbidity from both infectious and non-infectious diseases, amongst other adverse scenarios, is expected to rise globally in the future. The coming decade will be crucial for using all opportunities left to develop and implement adequate mitigation- and adaptation strategies.", "doi": "10.1016/j.ijid.2021.12.350", "pmid": "34973415", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)01250-9"}], "notes": [], "created": "2022-01-04T14:45:52.481Z", "modified": "2022-01-04T14:45:52.494Z"}, {"entity": "publication", "iuid": "2eed46b16b7d48628da3742f43526c30", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2eed46b16b7d48628da3742f43526c30.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2eed46b16b7d48628da3742f43526c30"}}, "title": "Disturbances in sleep, circadian rhythms and daytime functioning in relation to coronavirus infection and Long-COVID - A multinational ICOSS study.", "authors": [{"family": "Merikanto", "given": "Ilona", "initials": "I", "orcid": "0000-0002-1222-6678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50ed32f3146e4c0aa13e934d46eeb4af.json"}}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y"}, {"family": "Chung", "given": "Frances", "initials": "F"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L", "orcid": "0000-0003-3613-6631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e700e607f114414dba66aa366e3158b6.json"}}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK", "orcid": "0000-0002-5745-5474", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bbe4815f36d48959f5e81a5cf650088.json"}}, {"family": "Korman", "given": "Maria", "initials": "M"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "2nd ICOSS members", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-28", "journal": {"title": "J Sleep Res", "issn": "1365-2869", "pages": "e13542", "issn-l": "0962-1105"}, "abstract": "This protocol paper describes the second survey produced by the International Covid Sleep Study (ICOSS) group with the aim to examine the associations between SARS-CoV-2 infection and sleep, sleepiness, and circadian problems as potential predisposing factors for more severe COVID-19 disease profile and for development of Long-COVID in the general population. The survey consists of 47 questions on sleep, daytime sleepiness, circadian rhythm, health, mental wellbeing, life habits, and socioeconomic situation before and during the pandemic, and conditional questions to those reporting having had coronavirus infection, being vaccinated, or suffering from particular sleep symptoms or sleep disorders. Surveys will be administered online between May and November 2021 in Austria, Brazil, Bulgaria, Canada, China, Croatia, Finland, France, Germany, Israel, Italy, Japan, Norway, Portugal, Sweden and USA. Data collected by the survey will give valuable information on the open questions regarding COVID-19 disease risk factors, symptomatology and evolution of Long-COVID, and on other long-term consequences related to the pandemic.", "doi": "10.1111/jsr.13542", "pmid": "34964184", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:10:20.693Z", "modified": "2022-01-04T15:10:20.746Z"}, {"entity": "publication", "iuid": "ff0ff881a2e04993b01ac47c9fa43740", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff0ff881a2e04993b01ac47c9fa43740.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff0ff881a2e04993b01ac47c9fa43740"}}, "title": "Impact of COVID-19 Lockdown in Eating Disorders: A Multicentre Collaborative International Study.", "authors": [{"family": "Baenas", "given": "Isabel", "initials": "I"}, {"family": "Etxandi", "given": "Mikel", "initials": "M"}, {"family": "Mungu\u00eda", "given": "Lucero", "initials": "L", "orcid": "0000-0002-9751-810X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c45fa0084904a0daa70185f2c205f93.json"}}, {"family": "Granero", "given": "Roser", "initials": "R", "orcid": "0000-0001-6308-3198", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fcdba2a95cdb4c6ca52341bb3eaa8cd6.json"}}, {"family": "Mestre-Bach", "given": "Gemma", "initials": "G", "orcid": "0000-0001-5345-0484", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4bfd9cd50f94f16ae65c3efcb320ef9.json"}}, {"family": "S\u00e1nchez", "given": "Isabel", "initials": "I"}, {"family": "Ortega", "given": "Emilio", "initials": "E", "orcid": "0000-0002-2217-8905", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/967b2d8a952d4a64a3431d6377c9d623.json"}}, {"family": "Andreu", "given": "Alba", "initials": "A", "orcid": "0000-0001-9854-1531", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1ad984c75d446bba8e0b0711f92d492.json"}}, {"family": "Moize", "given": "Violeta L", "initials": "VL"}, {"family": "Fern\u00e1ndez-Real", "given": "Jose-Manuel", "initials": "JM"}, {"family": "Tinahones", "given": "Francisco J", "initials": "FJ"}, {"family": "Di\u00e9guez", "given": "Carlos", "initials": "C"}, {"family": "Fr\u00fchbeck", "given": "Gema", "initials": "G", "orcid": "0000-0002-8305-7154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5f1175d35d1415eb468c233efea3a7d.json"}}, {"family": "Le Grange", "given": "Daniel", "initials": "D", "orcid": "0000-0001-7293-9496", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f4e9d3d0bb3e4d6bbcadb48755345a0b.json"}}, {"family": "Tchanturia", "given": "Kate", "initials": "K", "orcid": "0000-0001-8988-3265", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27ec6341a4ed4a0eb1b9d0b2b4ba26b4.json"}}, {"family": "Karwautz", "given": "Andreas", "initials": "A", "orcid": "0000-0001-9053-998X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6fa0398cf9494fb8a627efe84d8ea526.json"}}, {"family": "Zeiler", "given": "Michael", "initials": "M", "orcid": "0000-0002-7087-6134", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64a514e9d496437a9ca03b3487761c78.json"}}, {"family": "Imgart", "given": "Hartmut", "initials": "H"}, {"family": "Zanko", "given": "Annika", "initials": "A"}, {"family": "Favaro", "given": "Angela", "initials": "A"}, {"family": "Claes", "given": "Laurence", "initials": "L", "orcid": "0000-0002-2287-3158", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05668afa36ac44e0a41baefe3fe15627.json"}}, {"family": "Shekriladze", "given": "Ia", "initials": "I", "orcid": "0000-0002-2787-0503", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6cbb53e06b24d05b7a06e27abe4025c.json"}}, {"family": "Serrano-Troncoso", "given": "Eduardo", "initials": "E"}, {"family": "Cecilia-Costa", "given": "Raquel", "initials": "R"}, {"family": "Rangil", "given": "Teresa", "initials": "T"}, {"family": "Loran-Meler", "given": "Maria Eulalia", "initials": "ME"}, {"family": "Soriano-Pacheco", "given": "Jos\u00e9", "initials": "J"}, {"family": "Carceller-Sindreu", "given": "Mar", "initials": "M"}, {"family": "Navarrete", "given": "Rosa", "initials": "R"}, {"family": "Lozano", "given": "Meritxell", "initials": "M"}, {"family": "Linares", "given": "Raquel", "initials": "R"}, {"family": "Gudiol", "given": "Carlota", "initials": "C"}, {"family": "Carratala", "given": "Jordi", "initials": "J", "orcid": "0000-0003-3209-2563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/457c5afc94f04abf8213883af22e6881.json"}}, {"family": "Plana", "given": "Maria T", "initials": "MT"}, {"family": "Graell", "given": "Montserrat", "initials": "M"}, {"family": "Gonz\u00e1lez-Parra", "given": "David", "initials": "D"}, {"family": "G\u00f3mez-Del Barrio", "given": "Jos\u00e9 A", "initials": "JA", "orcid": "0000-0002-0843-2575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6859029c9c794890b4c413182e6ebd6d.json"}}, {"family": "Sep\u00falveda", "given": "Ana R", "initials": "AR", "orcid": "0000-0002-6041-2889", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17286862c654184bd6d2c372ed2dd34.json"}}, {"family": "S\u00e1nchez-Gonz\u00e1lez", "given": "J\u00e9ssica", "initials": "J"}, {"family": "Machado", "given": "Paulo P P", "initials": "PPP", "orcid": "0000-0003-4277-9203", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78c76a513fda475389e9733feed37285.json"}}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A", "orcid": "0000-0002-5800-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec14ecdcc0654d8ea864f64ce195752b.json"}}, {"family": "T\u00fary", "given": "Ferenc", "initials": "F", "orcid": "0000-0002-7283-5088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6552d5b04a814f7ca33d605d11bb6066.json"}}, {"family": "P\u00e1szthy", "given": "Bea", "initials": "B"}, {"family": "Stein", "given": "Daniel", "initials": "D"}, {"family": "Papezov\u00e1", "given": "Hana", "initials": "H"}, {"family": "Gricova", "given": "Jana", "initials": "J"}, {"family": "Bax", "given": "Brigita", "initials": "B"}, {"family": "Borisenkov", "given": "Mikhail F", "initials": "MF", "orcid": "0000-0002-4310-2010", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9cefa16d6c14d8fbbef76031166b08b.json"}}, {"family": "Popov", "given": "Sergey V", "initials": "SV", "orcid": "0000-0003-1763-8898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/740f23b384674f6681e744c38593bc32.json"}}, {"family": "Gubin", "given": "Denis G", "initials": "DG"}, {"family": "Petrov", "given": "Ivan M", "initials": "IM", "orcid": "0000-0003-0823-3434", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54707d4b6a1c43dd8ced55e544ecbdc8.json"}}, {"family": "Isakova", "given": "Dilara", "initials": "D"}, {"family": "Mustafina", "given": "Svetlana V", "initials": "SV", "orcid": "0000-0003-4716-876X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3822f19c5c474c4784a6cf63b18bfe8f.json"}}, {"family": "Kim", "given": "Youl-Ri", "initials": "YR"}, {"family": "Nakazato", "given": "Michiko", "initials": "M", "orcid": "0000-0002-4025-7594", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1b76b8cf7c947cd96fb042248ab8d71.json"}}, {"family": "Godart", "given": "Nathalie", "initials": "N"}, {"family": "van Voren", "given": "Robert", "initials": "R"}, {"family": "Ilnytska", "given": "Tetiana", "initials": "T", "orcid": "0000-0003-1734-1568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dfd94d8f0d0b43e5abf6732f7b8b7362.json"}}, {"family": "Chen", "given": "Jue", "initials": "J"}, {"family": "Rowlands", "given": "Katie", "initials": "K"}, {"family": "Voderholzer", "given": "Ulrich", "initials": "U", "orcid": "0000-0003-0261-3145", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07d8956c0b9942559bf43303a1df32d5.json"}}, {"family": "Monteleone", "given": "Alessio M", "initials": "AM"}, {"family": "Treasure", "given": "Janet", "initials": "J"}, {"family": "Jim\u00e9nez-Murcia", "given": "Susana", "initials": "S", "orcid": "0000-0002-3596-8033", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ac03a841eb041898475d397a496f40d.json"}}, {"family": "Fern\u00e1ndez-Aranda", "given": "Fernando", "initials": "F", "orcid": "0000-0002-2968-9898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc6962e9696f4bb68aac669a99db8ad6.json"}}], "type": "journal article", "published": "2021-12-27", "journal": {"title": "Nutrients", "issn": "2072-6643", "volume": "14", "issue": "1", "issn-l": null}, "abstract": "The COVID-19 lockdown has had a significant impact on mental health. Patients with eating disorders (ED) have been particularly vulnerable.\n\n(1) To explore changes in eating-related symptoms and general psychopathology during lockdown in patients with an ED from various European and Asian countries; and (2) to assess differences related to diagnostic ED subtypes, age, and geography.\n\nThe sample comprised 829 participants, diagnosed with an ED according to DSM-5 criteria from specialized ED units in Europe and Asia. Participants were assessed using the COVID-19 Isolation Scale (CIES).\n\nPatients with binge eating disorder (BED) experienced the highest impact on weight and ED symptoms in comparison with other ED subtypes during lockdown, whereas individuals with other specified feeding and eating disorders (OFSED) had greater deterioration in general psychological functioning than subjects with other ED subtypes. Finally, Asian and younger individuals appeared to be more resilient.\n\nThe psychopathological changes in ED patients during the COVID-19 lockdown varied by cultural context and individual variation in age and ED diagnosis. Clinical services may need to target preventive measures and adapt therapeutic approaches for the most vulnerable patients.", "doi": "10.3390/nu14010100", "pmid": "35010974", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "nu14010100"}], "notes": [], "created": "2022-01-13T21:06:58.879Z", "modified": "2022-01-13T21:06:59.811Z"}, {"entity": "publication", "iuid": "d488e23ab7044f878bd2c3574727a9a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d488e23ab7044f878bd2c3574727a9a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d488e23ab7044f878bd2c3574727a9a2"}}, "title": "Disease severity related to VOC dominance in unvaccinated SARS-CoV-2 positive adults without risk factors in Sweden", "authors": [{"family": "Wahlstr\u00f6m", "given": "Erik", "initials": "E", "orcid": "0000-0002-0800-8520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f623177f84a4f4ba85571b106e4cec5.json"}}, {"family": "Bruce", "given": "Daniel", "initials": "D"}, {"family": "Bennet Bark", "given": "Anna M", "initials": "AM"}, {"family": "Walther", "given": "Sten", "initials": "S"}, {"family": "Hanberger", "given": "H\u00e5kan", "initials": "H", "orcid": "0000-0002-4199-0229", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ccccceb630874fc5ab7507a313b59039.json"}}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-8801-3169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37509c3832244b019b91a1fe2cbe183e.json"}}], "type": "posted-content", "published": "2021-12-27", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.12.23.21268040", "pmid": null, "labels": {"Type: Preprint": null, "Category: Vaccines": null, "Category: Health": null, "Funder: VR": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:42:57.654Z", "modified": "2022-01-04T15:43:35.405Z"}, {"entity": "publication", "iuid": "0814a4ea41f54f73a151983bdea6511c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0814a4ea41f54f73a151983bdea6511c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0814a4ea41f54f73a151983bdea6511c"}}, "title": "Clinical grade ACE2 effectively inhibits SARS-CoV-2 Omicron infections", "authors": [{"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Stephanie", "given": "Devignot", "initials": "D"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Kellner", "given": "Max J", "initials": "MJ"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Mereiter", "given": "Stefan", "initials": "S"}, {"family": "Knapp", "given": "Sylvia", "initials": "S"}, {"family": "Montserrat", "given": "Nuria", "initials": "N"}, {"family": "Braunsfeld", "given": "Benedict", "initials": "B"}, {"family": "Kozieradzki", "given": "Ivona", "initials": "I"}, {"family": "Ali", "given": "Omar Hasan", "initials": "OH"}, {"family": "Hagelkruys", "given": "Astrid", "initials": "A"}, {"family": "Stadlmann", "given": "Johannes", "initials": "J"}, {"family": "Oostenbrink", "given": "Chris", "initials": "C"}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}], "type": "posted-content", "published": "2021-12-27", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.12.25.474113", "pmid": null, "labels": {"Category: Health": null, "Type: Preprint": null, "Category: Biochemistry": null, "Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null, "Category: Omicron VoC": null}, "xrefs": [], "notes": [], "created": "2022-01-17T10:10:34.079Z", "modified": "2022-01-21T16:21:24.414Z"}, {"entity": "publication", "iuid": "82393755f88348d28f9b87e3f8855197", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82393755f88348d28f9b87e3f8855197.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82393755f88348d28f9b87e3f8855197"}}, "title": "Brand-Specific Enhanced Safety Surveillance Study of GSK's Quadrivalent Seasonal Influenza Vaccine, Conducted During the COVID-19 Pandemic, in Belgium, Germany and Spain, for the 2020/21 Season.", "authors": [{"family": "Dos Santos", "given": "Ga\u00ebl", "initials": "G", "orcid": "0000-0001-8623-3478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e24881d9d6a54aebbc46d19ecd6db87b.json"}}, {"family": "Wang", "given": "Hao", "initials": "H", "orcid": "0000-0001-8293-6969", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1b2f6e2c99943c4ad8699c47c7ffdad.json"}}, {"family": "Jindal", "given": "Pooja", "initials": "P", "orcid": "0000-0001-6528-8875", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ac2ddaacf10499aa5215402e247e31d.json"}}, {"family": "Rybo", "given": "Maria", "initials": "M", "orcid": "0000-0002-6678-0455", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822d718fbc3c49778221473c87ed2c16.json"}}, {"family": "Roul", "given": "H\u00e9l\u00e8ne", "initials": "H", "orcid": "0000-0001-9912-6540", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73b2d969cf3b411ea76655257410a811.json"}}, {"family": "Pallem", "given": "Sridevi", "initials": "S", "orcid": "0000-0002-8435-7132", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f3e1c7911a142f18c155f04959746bc.json"}}, {"family": "Eckermann", "given": "Tamara", "initials": "T"}, {"family": "Godderis", "given": "Lode", "initials": "L", "orcid": "0000-0003-4764-8835", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/639b8bdac78742e9aeebe5b33c6dfedb.json"}}, {"family": "Mart\u00ednez G\u00f3mez", "given": "Xavier", "initials": "X", "orcid": "0000-0003-4583-9734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/17a4aee6258946b388292ad1a0d9255a.json"}}, {"family": "Godard", "given": "Eric", "initials": "E"}, {"family": "Soler", "given": "Muriel", "initials": "M", "orcid": "0000-0002-8169-0730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/63db46695baa4e3c8652cdf990f65d9b.json"}}, {"family": "Yousefi", "given": "Mitra", "initials": "M", "orcid": "0000-0003-3076-5701", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31e3ce5af02d4535aaaf6f440b77e8e7.json"}}, {"family": "Salamanca de la Cueva", "given": "Ignacio", "initials": "I", "orcid": "0000-0003-0561-9913", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ecdb4aaf428b40c78ab014c41fa8e320.json"}}, {"family": "Nwoji", "given": "Ugo", "initials": "U", "orcid": "0000-0002-2946-703X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e630d6f34a914319ba2dd25204adb0fc.json"}}], "type": "journal article", "published": "2021-12-27", "journal": {"title": "Infect Dis Ther", "issn": "2193-8229", "issn-l": null}, "abstract": "Seasonal influenza poses a major public health burden worldwide. Influenza vaccines, updated yearly to match circulating strains based on World Health Organization (WHO) recommendations, are the cornerstone of prevention and require regular monitoring. The COVID-19 pandemic is expected to cause logistical, site access and medical staff constraints and could affect the safety profile of influenza vaccines.\n\nFollowing European Medicines Agency guidance, an enhanced safety surveillance (ESS) study assessed the frequency and severity of predefined and other adverse events (AEs) occurring within 7 days of receiving GSK's inactivated quadrivalent seasonal influenza vaccine (IIV4), in Belgium, Germany and Spain in 2020/21, using adverse drug reaction (ADR) cards.\n\nDuring the 2020/21 influenza season, 1054 participants vaccinated with GSK's IIV4 were enrolled (all adults in Belgium and Germany, 30% adults/70% children in Spain); 96 eligible children received a second dose. Overall, 1042 participants completed the study. After doses 1 and 2, 98.9% and 100% of participants, respectively, returned their completed ADR card. After doses 1 and 2, 37.8% (398/1054) and 13.5% (13/96) of participants, respectively, reported at least one AE. The most frequently reported categories of AEs were \"general disorders and administration site conditions\" (e.g. injection site pain) and \"nervous system disorders\" (e.g. headache). There were no deaths or serious AEs deemed related to GSK's IIV4.\n\nThis ESS study assessed AEs in near real time. The COVID-19 pandemic did not alter the safety profile of GSK's IIV4. No safety signals were detected during the study, which confirms the excellent safety profile of GSK's IIV4.", "doi": "10.1007/s40121-021-00571-y", "pmid": "34961900", "labels": {"Category: Post-COVID": null, "Category: Vaccines": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40121-021-00571-y"}, {"db": "pmc", "key": "PMC8711683"}], "notes": [], "created": "2022-01-04T15:10:47.472Z", "modified": "2022-01-04T15:10:47.851Z"}, {"entity": "publication", "iuid": "339ebb8c228e4553bec7ec6e3ad6f6c8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/339ebb8c228e4553bec7ec6e3ad6f6c8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/339ebb8c228e4553bec7ec6e3ad6f6c8"}}, "title": "A large scale meta-analytic atlas of mental health problems prevalence during the COVID-19 early pandemic.", "authors": [{"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Li", "given": "Han", "initials": "H"}, {"family": "Tsitsas", "given": "George", "initials": "G"}, {"family": "Lee", "given": "Keum Hwa", "initials": "KH"}, {"family": "Choi", "given": "Jiwoo", "initials": "J"}, {"family": "Kim", "given": "Jiwon", "initials": "J"}, {"family": "Choi", "given": "Young Jo", "initials": "YJ"}, {"family": "Tsamakis", "given": "Konstantinos", "initials": "K"}, {"family": "Estrad\u00e9", "given": "Andr\u00e9s", "initials": "A"}, {"family": "Agorastos", "given": "Agorastos", "initials": "A"}, {"family": "Vancampfort", "given": "Davy", "initials": "D"}, {"family": "Tsiptsios", "given": "Dimitrios", "initials": "D"}, {"family": "Thompson", "given": "Trevor", "initials": "T"}, {"family": "Mosina", "given": "Anna", "initials": "A"}, {"family": "Vakadaris", "given": "Georgios", "initials": "G"}, {"family": "Fusar-Poli", "given": "Paolo", "initials": "P"}, {"family": "Carvalho", "given": "Andre F", "initials": "AF"}, {"family": "Correll", "given": "Christoph U", "initials": "CU"}, {"family": "Han", "given": "Young Joo", "initials": "YJ"}, {"family": "Park", "given": "Seoyeon", "initials": "S"}, {"family": "Il Shin", "given": "Jae", "initials": "J"}, {"family": "Solmi", "given": "Marco", "initials": "M"}], "type": "journal article", "published": "2021-12-27", "journal": {"title": "J Med Virol", "issn": "1096-9071", "issn-l": null}, "abstract": "The COVID-19 pandemic and related restrictions can impact mental health. In order to quantify the mental health burden of COVID-19 pandemic, we conducted a systematic review and meta-analysis, searching World Health Organization COVID-19/PsycInfo/PubMed databases (09/29/2020), including observational studies reporting on mental health outcomes in any population affected by COVID-19. Primary outcomes were the prevalence of anxiety, depression, stress, sleep problems, post-traumatic symptoms. Sensitivity analyses were conducted on severe mental health problems, in high-quality studies, and in representative samples. Subgroup analyses were conducted stratified by age, sex, country income level, and COVID-19 infection status. One-hundred-seventy-three studies from February-July 2020 were included (n=502,261, median sample=948, age=34.4 years, females=63%). Ninety-one percent were cross-sectional studies, and 18.5%/57.2% were of high/moderate quality. Highest prevalence emerged for post-traumatic symptoms in COVID-19 infected people (94%), followed by behavioural problems in those with prior mental disorders (77%), fear in healthcare workers (71%), anxiety in caregivers/family members of people with COVID-19 (42%), general health/social contact/passive coping style in the general population (38%), depression in those with prior somatic disorders (37%), and fear in other-than-healthcare workers (29%). Females and people with COVID-19 infection had higher rates of almost all outcomes; college students/young adults of anxiety, depression, sleep problems, suicidal ideation; adults of fear and post-traumatic symptoms. Anxiety, depression, and post-traumatic symptoms were more prevalent in low-/middle-income countries, sleep problems in high-income countries. The COVID-19 pandemic adversely impacts mental health in unique manners across population subgroups. Our results inform tailored preventive strategies and interventions to mitigate current, future, and transgenerational adverse mental health of the COVID-19 pandemic. This article is protected by copyright. All rights reserved.", "doi": "10.1002/jmv.27549", "pmid": "34958144", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:24:01.051Z", "modified": "2022-01-04T15:24:28.475Z"}, {"entity": "publication", "iuid": "12990ec8a3de4a1cb085b315d2fe3209", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/12990ec8a3de4a1cb085b315d2fe3209.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/12990ec8a3de4a1cb085b315d2fe3209"}}, "title": "Validating Insomnia Severity Index (ISI) in a Bangladeshi Population: Using Classical Test Theory and Rasch Analysis.", "authors": [{"family": "Mamun", "given": "Mohammed A", "initials": "MA", "orcid": "0000-0002-1728-8966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6e65a5a97154d159a63cc2ce3f1b7a8.json"}}, {"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Gozal", "given": "David", "initials": "D", "orcid": "0000-0001-8195-6036", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50940954296643fabb4d15a69d4e4bb4.json"}}, {"family": "Manzar", "given": "Md Dilshad", "initials": "MD", "orcid": "0000-0002-5571-3310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/003777905ef4485fa4fd18c9f0cc16ec.json"}}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Huang", "given": "Ru-Yi", "initials": "RY", "orcid": "0000-0001-6867-7171", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3169b8bbbc4f4409961cbd2cf47b2c6b.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-12-25", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "1", "issn-l": null}, "abstract": "The COVID-19 outbreak is associated with sleep problems and mental health issues among individuals. Therefore, there is a need to assess sleep efficiency during this tough period. Unfortunately, the commonly used instrument on insomnia severity-the Insomnia Severity Index (ISI)-has never been translated and validated among Bangladeshis. Additionally, the ISI has never been validated during a major protracted disaster (such as the COVID-19 outbreak) when individuals encounter mental health problems. The present study aimed to translate the ISI into Bangla language (ISI-Bangla) and validate its psychometric properties. First, the linguistic validity of the ISI-Bangla was established. Then, 9790 Bangladeshis (mean age = 26.7 years; SD = 8.5; 5489 [56.1%] males) completed the Bangla versions of the following questionnaires: ISI, Fear of COVID-19 Scale (FCV-19S), and Patient Health Questionnaire-9 (PHQ-9). All the participants also answered an item on suicidal ideation. Classical test theory and Rasch analyses were conducted to evaluate the psychometric properties of the ISI-Bangla. Both classical test theory and Rasch analyses support a one-factor structure for the ISI-Bangla. Moreover, no substantial differential item functioning was observed across different subgroups (gender, depression status (determined using PHQ-9), and suicidal ideation). Additionally, concurrent validity of the ISI-Bangla was supported by significant and moderate correlations with FCV-19S and PHQ-9; known-group validity was established by the significant difference of the ISI-Bangla scores between participants who experienced suicidal ideation and those without. The present psychometric validation conducted during the COVID-19 outbreak suggests that the ISI-Bangla is a promising and operationally adequate instrument to assess insomnia in Bangladeshis.", "doi": "10.3390/ijerph19010225", "pmid": "35010485", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph19010225"}], "notes": [], "created": "2022-01-13T21:08:26.021Z", "modified": "2022-01-13T21:08:26.201Z"}, {"entity": "publication", "iuid": "d3698936851f43e5bff38669fd8afc2e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3698936851f43e5bff38669fd8afc2e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3698936851f43e5bff38669fd8afc2e"}}, "title": "Surgical helmets can be converted into efficient disinfectable powered air-purifying respirators.", "authors": [{"family": "Temmesfeld", "given": "Max", "initials": "M"}, {"family": "Gorzkowska-Sobas", "given": "Agnieszka Anna", "initials": "AA"}, {"family": "Hedlund", "given": "Kenny", "initials": "K"}, {"family": "\u00d8yen", "given": "Martin \u00d8hlund", "initials": "M\u00d8"}, {"family": "Kanten", "given": "Lars", "initials": "L"}, {"family": "Grant", "given": "Peter", "initials": "P"}, {"family": "Jakobsen", "given": "Rune B", "initials": "RB"}], "type": "journal article", "published": "2021-12-25", "journal": {"title": "Am J Infect Control", "issn": "1527-3296", "issn-l": null}, "abstract": "Filtering facepiece respirators often fail to provide sufficient protection due to a poor fit. Powered air-purifying respirators (PAPRs) are not designed for healthcare personnel, and are challenging to disinfect. Surgical helmets (SH) are available in many US hospitals but do not provide respiratory protection. Several modifications to SH have been suggested, but none are sufficiently compliant with safety and efficiency standards. The purpose of this investigation was the development of a filter adaptor, which converts SHs into efficient, safe and disinfectable PAPRs.\n\nFour critical features were investigated close to regulatory requirements: total inward leakage (TIL) of particles, CO2 concentrations, intra-helmet differential pressure, and automated disinfection.\n\nThe average TIL in the two independent tests were 0.005% and 0.01%. CO2 concentrations were lower than in the original SH. The modification generates a positive differential pressure. The filter's performance was not compromised after 50 cycles in a sterilization machine.\n\nThe modified SH provides several hundred times better protection than FFP-3 masks.\n\nSurgical helmets can be modified into safe, efficient, and disinfectable PAPRs, suitable for HCP and the OR in particular. They can play a role in the preparedness for upcoming events requiring efficient respiratory protection.", "doi": "10.1016/j.ajic.2021.12.002", "pmid": "34958857", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0196-6553(21)00841-5"}], "notes": [], "created": "2022-01-04T15:23:41.932Z", "modified": "2022-01-04T15:23:41.946Z"}, {"entity": "publication", "iuid": "492db880c06643539af84fc60d1a3e89", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/492db880c06643539af84fc60d1a3e89.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/492db880c06643539af84fc60d1a3e89"}}, "title": "Influenza A H1N1\u2013mediated pre-existing immunity to SARS-CoV-2 predicts COVID-19 outbreak dynamics", "authors": [{"family": "Almaz\u00e1n", "given": "Nerea Mart\u00edn", "initials": "NM"}, {"family": "Rahbar", "given": "Afsar", "initials": "A"}, {"family": "Carlsson", "given": "Marcus", "initials": "M"}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Kolstad", "given": "Linda", "initials": "L"}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B"}, {"family": "Pantalone", "given": "Mattia Russel", "initials": "MR"}, {"family": "Fuchs", "given": "Ilona Lewensohn", "initials": "IL"}, {"family": "Naucl\u00e9r", "given": "Anna", "initials": "A"}, {"family": "Ohlin", "given": "Mats", "initials": "M"}, {"family": "Sacharczuk", "given": "Mariusz", "initials": "M"}, {"family": "Religa", "given": "Piotr", "initials": "P"}, {"family": "Am\u00e9r", "given": "Stefan", "initials": "S"}, {"family": "Moln\u00e1r", "given": "Christian", "initials": "C"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Susrud", "given": "Andres", "initials": "A"}, {"family": "S\u00f6rensen", "given": "Birger", "initials": "B"}, {"family": "S\u00f6derberg-Naucl\u00e9r", "given": "Cecilia", "initials": "C"}], "type": "posted-content", "published": "2021-12-25", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.12.23.21268321", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null, "Category: Genomics & transcriptomics": null, "Funder: KAW/SciLifeLab": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Drug discovery and repurposing of drugs": null, "Category: Omicron VoC": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:44:30.390Z", "modified": "2022-02-14T14:40:41.897Z"}, {"entity": "publication", "iuid": "28e70e03c04d4f56aa48b44cb2361a06", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/28e70e03c04d4f56aa48b44cb2361a06.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/28e70e03c04d4f56aa48b44cb2361a06"}}, "title": "Acute Stress in Health Workers during Two Consecutive Epidemic Waves of COVID-19.", "authors": [{"family": "J\u00e1uregui Renaud", "given": "Kathrine", "initials": "K", "orcid": "0000-0002-2165-1422", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15f62be9e24a4fac9cdbcdeaafcdf713.json"}}, {"family": "Cooper-Bribiesca", "given": "Davis", "initials": "D", "orcid": "0000-0002-4273-1181", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a29e74edc3fd4cad8860996e46014d6f.json"}}, {"family": "Mart\u00ednez-Pichardo", "given": "Elizabet", "initials": "E"}, {"family": "Miguel Puga", "given": "Jos\u00e9 A", "initials": "JA"}, {"family": "Rasc\u00f3n-Mart\u00ednez", "given": "Dulce M", "initials": "DM", "orcid": "0000-0002-3074-679X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ecd8f18e63eb4506b0ac6bfbcf01c4da.json"}}, {"family": "S\u00e1nchez Hurtado", "given": "Luis A", "initials": "LA"}, {"family": "Colin Mart\u00ednez", "given": "Tania", "initials": "T"}, {"family": "Espinosa-Poblano", "given": "Eliseo", "initials": "E"}, {"family": "Anda-Garay", "given": "Juan Carlos", "initials": "JC"}, {"family": "Gonz\u00e1lez Diaz", "given": "Jorge I", "initials": "JI"}, {"family": "Carde\u00f1a", "given": "Etzel", "initials": "E"}, {"family": "Avelar Garnica", "given": "Francisco", "initials": "F"}], "type": "journal article", "published": "2021-12-25", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "1", "issn-l": null}, "abstract": "The COVID-19 pandemic has provoked generalized uncertainty around the world, with health workers experiencing anxiety, depression, burnout, insomnia, and stress. Although the effects of the pandemic on mental health may change as it evolves, the majority of reports have been web-based, cross-sectional studies. We performed a study assessing acute stress in frontline health workers during two consecutive epidemic waves. After screening for trait anxiety/depression and dissociative experiences, we evaluated changes in acute stress, considering resilience, state anxiety, burnout, depersonalization/derealization symptoms, and quality of sleep as cofactors. During the first epidemic wave (April 2020), health workers reported acute stress related to COVID-19, which was related to state anxiety. After the first epidemic wave, acute stress decreased, with no increase during the second epidemic wave (December 2020), and further decreased when vaccination started. During the follow-up (April 2020 to February 2021), the acute stress score was related to bad quality of sleep. However, acute stress, state anxiety, and burnout were all related to trait anxiety/depression, while the resilience score was invariant through time. Overall, the results emphasize the relevance of mental health screening before, during, and after an epidemic wave of infections, in order to enable coping during successive sanitary crises.", "doi": "10.3390/ijerph19010206", "pmid": "35010465", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph19010206"}], "notes": [], "created": "2022-01-13T21:08:44.552Z", "modified": "2022-01-13T21:08:44.686Z"}, {"entity": "publication", "iuid": "c7a4115a060d4271ae3121c23213beaf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7a4115a060d4271ae3121c23213beaf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7a4115a060d4271ae3121c23213beaf"}}, "title": "The incidence of melanoma during the COVID-19 pandemic in a Swedish health care region without lockdown.", "authors": [{"family": "Pissa", "given": "Maria", "initials": "M"}, {"family": "Gulin", "given": "Sandra Jerkovic", "initials": "SJ"}], "type": "journal article", "published": "2021-12-24", "journal": {"title": "JAAD Int", "issn": "2666-3287", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jdin.2021.12.004", "pmid": "34977816", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-3287(21)00104-8"}, {"db": "pmc", "key": "PMC8702400"}], "notes": [], "created": "2022-01-04T14:44:22.298Z", "modified": "2022-01-04T14:44:22.336Z"}, {"entity": "publication", "iuid": "6f7c3e78cc6a451989d470d385d4948e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f7c3e78cc6a451989d470d385d4948e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f7c3e78cc6a451989d470d385d4948e"}}, "title": "SARS-CoV-2 Post Vaccinated Adverse Effects and Efficacy in the Egyptian Population.", "authors": [{"family": "Elgendy", "given": "Marwa O", "initials": "MO", "orcid": "0000-0002-5466-0552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/092137ee2845486aa4c0a926a2d4c0a2.json"}}, {"family": "El-Gendy", "given": "Ahmed O", "initials": "AO", "orcid": "0000-0002-0980-5185", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37a05711bd4f4a67bd6af36f6df989e6.json"}}, {"family": "Alzarea", "given": "Abdulaziz Ibrahim", "initials": "AI", "orcid": "0000-0003-0604-6299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb86c921515b4f69b3ee4a9c496ee44e.json"}}, {"family": "Mahmoud", "given": "Sarah", "initials": "S"}, {"family": "Alqahtani", "given": "Saad S", "initials": "SS"}, {"family": "Fahmy", "given": "Alzhraa M", "initials": "AM"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}, {"family": "Sayed", "given": "Ahmed M", "initials": "AM", "orcid": "0000-0002-1442-183X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/013ee0ba73bb4d7f87fd285c65e49725.json"}}, {"family": "Alatawi", "given": "Ahmed D", "initials": "AD"}, {"family": "Abdelrahim", "given": "Mohamed E A", "initials": "MEA", "orcid": "0000-0003-0227-8404", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/feb86f846aee415dac74ef2f455ecb42.json"}}, {"family": "Alanazi", "given": "Abdullah S", "initials": "AS", "orcid": "0000-0002-8120-4018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22f197492bd64d478a6c5ac6072708c6.json"}}], "type": "journal article", "published": "2021-12-24", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "1", "issn-l": null}, "abstract": "Vaccines are the solution to overcome SARS-CoV-2. This study aimed to determine the post-Sinopharm vaccine safety-profile and immunity through antibody titers. Data were collected using a structured questionnaire from Egyptian participants who received two doses of Sinopharm vaccine. Data were divided into three parts, the first and second parts were to detect participants' post-first and second dose symptoms and practices, and the third for the results of IgG anti spike protein antibodies test and laboratory tests. Pain, redness, swelling at the injection site, headache, fatigue, and lethargy were the most common post-vaccine symptoms for both first and second doses. Most of the participants felt mild or no symptoms after vaccination. The symptoms started mostly during the first day post-vaccination and lasted for no more than two days. Forty-nine percent of the participants resulted in positive antibodies tests on day 18 post-vaccination. The average antibody level for vaccinated participants with past SARS-CoV-2 infection was much higher than that for non-past infected participants. These vaccines' administration methods need to be reevaluated by changing the dose, dose interval, adding a third dose, or mixing it with other vaccines with different techniques to improve their protection rates. Further studies are required to validate this finding.", "doi": "10.3390/vaccines10010018", "pmid": "35062679", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "vaccines10010018"}], "notes": [], "created": "2022-01-26T10:19:21.276Z", "modified": "2022-01-26T10:19:42.647Z"}, {"entity": "publication", "iuid": "a7d9bdf7e3a041e482c3586e9755e774", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7d9bdf7e3a041e482c3586e9755e774.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7d9bdf7e3a041e482c3586e9755e774"}}, "title": "Personal Social Networks of Community-Dwelling Oldest Old During the Covid-19 Pandemic-A Qualitative Study.", "authors": [{"family": "Kulmala", "given": "Jenni", "initials": "J"}, {"family": "Tiilikainen", "given": "Elisa", "initials": "E"}, {"family": "Lisko", "given": "Inna", "initials": "I"}, {"family": "Ngandu", "given": "Tiia", "initials": "T"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Solomon", "given": "Alina", "initials": "A"}], "type": "journal article", "published": "2021-12-24", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "770965", "issn-l": "2296-2565"}, "abstract": "The COVID-19 pandemic and its related restrictions have affected the everyday life of older people. Advanced age is a significant predisposing factor for a more severe COVID-19 infection, increasing the risk for hospitalization and mortality. Even though restrictions have been, thus, well-grounded, they may also have had detrimental effects on the social well-being of older people. Personal networks and social activity are known protective factors against the premature decline in health and functioning, and it is widely acknowledged that social isolation increases feelings of loneliness, poor quality of life, and even the risk for diseases and disabilities among older adults. This qualitative study investigated changes in personal networks among community-dwelling oldest-old individuals (persons aged 80 and over) during the first and second waves of the COVID-19 pandemic in Finland. The data is part of the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE85+) study, which is an ongoing large longitudinal population-based study in Finland. In this qualitative sub-study, we analyzed fifteen in-depth telephone interviews using directed content analyses and identified five types of changes in personal social networks during the pandemic. In type 1, all social contacts were significantly reduced due to official recommendations and fear of the virus. Type 2 included modified ways of being socially active i.e., by deploying new technology, and in type 3, social contacts increased during the lockdown. In type 4, personal social networks were changed unexpectedly or dramatically due to a death of a spouse, for example. In type 5, we observed stable social networks, which had not been affected by the pandemic. At an individual level, one person could have had different types of changes during the pandemic. These results highlight the heterogeneity of the oldest olds' personal social networks and changes related to them during the exceptional times of the COVID-19 pandemic. Social activity and personal networks play an important role in the well-being of the oldest old, but individual situations, needs, and preferences toward personal social networks should be taken into account when planning social activities, policies, and interventions.", "doi": "10.3389/fpubh.2021.770965", "pmid": "35004583", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8739883"}], "notes": [], "created": "2022-01-13T21:10:36.758Z", "modified": "2022-01-13T21:10:36.774Z"}, {"entity": "publication", "iuid": "67e12edf73e84fa38eb02d787339cf33", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/67e12edf73e84fa38eb02d787339cf33.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/67e12edf73e84fa38eb02d787339cf33"}}, "title": "COVID-19 and stillbirth: direct vs indirect effect of the pandemic.", "authors": [{"family": "Khalil", "given": "A", "initials": "A", "orcid": "0000-0003-2802-7670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e4558e368114cfb83c4594f523b38c0.json"}}, {"family": "Blakeway", "given": "H", "initials": "H"}, {"family": "Samara", "given": "A", "initials": "A"}, {"family": "O'Brien", "given": "P", "initials": "P"}], "type": "journal article", "published": "2021-12-24", "journal": {"title": "Ultrasound Obstet Gynecol", "issn": "1469-0705", "issn-l": null}, "abstract": null, "doi": "10.1002/uog.24846", "pmid": "34951732", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:26:30.102Z", "modified": "2022-01-04T15:26:30.156Z"}, {"entity": "publication", "iuid": "0f880ab1d5454514afb4045f0c9a7704", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0f880ab1d5454514afb4045f0c9a7704.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0f880ab1d5454514afb4045f0c9a7704"}}, "title": "Response to Letter to the Editor: Comment on \"Body mass index and Mini Nutritional Assessment-Short Form as predictors of in-geriatric hospital mortality in older adults with COVID-19\" (by Caf\u00e9 Balc\u0131, MD, Hacettepe University Faculty of Medicine Department of Internal Medicine Division of Geriatric Medicine).", "authors": [{"family": "Kananen", "given": "Laura", "initials": "L"}, {"family": "Religa", "given": "Dorota", "initials": "D"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}, {"family": "H\u00e4gg", "given": "Sara", "initials": "S"}, {"family": "Julh\u00e4v\u00e4", "given": "Juulia", "initials": "J"}, {"family": "Cederholm", "given": "Tommy", "initials": "T"}], "type": "letter", "published": "2021-12-23", "journal": {"title": "Clin Nutr", "issn": "1532-1983", "issn-l": null}, "abstract": null, "doi": "10.1016/j.clnu.2021.12.027", "pmid": "35027222", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0261-5614(21)00584-7"}, {"db": "pmc", "key": "PMC8695347"}], "notes": [], "created": "2022-01-27T08:13:47.281Z", "modified": "2022-01-27T08:13:47.286Z"}, {"entity": "publication", "iuid": "5fa87903c2a649fb95e9eba28af4b30b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5fa87903c2a649fb95e9eba28af4b30b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5fa87903c2a649fb95e9eba28af4b30b"}}, "title": "Distance Learning Effects Among Italian Children and Parents During COVID-19 Related School Lockdown.", "authors": [{"family": "Crisci", "given": "Giulia", "initials": "G"}, {"family": "Mammarella", "given": "Irene C", "initials": "IC"}, {"family": "Moscardino", "given": "Ughetta M M", "initials": "UMM"}, {"family": "Roch", "given": "Maja", "initials": "M"}, {"family": "Thorell", "given": "Lisa B", "initials": "LB"}], "type": "journal article", "published": "2021-12-23", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "782353", "issn-l": "1664-0640"}, "abstract": "Background: During the COVID-19 pandemic, both children and their parents experienced consequences related to distance learning (DL). However, positive and negative effects have varied greatly among families, and the specific factors explaining these differences in experiences are still underexplored. In this study, we examined children's executive functions (EF) and parents' psychological well-being in relation to negative and positive effects of DL on both children and their parents. Method: Participants were 637 Italian parents (92% mothers) with a child (48% male) aged between 6 and 19 years involved in DL due to school closures during the first wave of the COVID-19 pandemic. Data were collected using an online survey. We performed three fixed-order hierarchical multiple regression analyses with child age and sex, children's EF deficits, and parents' psychological well-being as independent variables, and DL-related negative effects (on the child and on the parent) and DL-related positive effects as dependent variables. Results: The results of the regression analyses showed that for negative effects of DL, younger age and greater EF deficits explained most part of the variance. Specifically, regarding negative effects on children, the most important factor was EF deficits, whereas regarding negative effects on parents, child age was the most important factor. For positive effects of DL, all variables explained only a small part of the variance. Child age was the most important factor, but EF deficits and parents' psychological well-being also had a significant impact. Conclusions: The effects of DL during school closures vary widely across families. Our findings indicate that intervention efforts need to consider background variables, child factors, as well as parent factors when supporting families with homeschooling in times of pandemic.", "doi": "10.3389/fpsyt.2021.782353", "pmid": "35002803", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8732950"}], "notes": [], "created": "2022-01-13T21:11:22.012Z", "modified": "2022-01-13T21:11:22.026Z"}, {"entity": "publication", "iuid": "f7fc256aa7c44d34ad6da0ab245d9b4e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7fc256aa7c44d34ad6da0ab245d9b4e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7fc256aa7c44d34ad6da0ab245d9b4e"}}, "title": "Androgen deprivation therapy, comorbidity, cancer stage and mortality from COVID-19 in men with prostate cancer.", "authors": [{"family": "Gedeborg", "given": "Rolf", "initials": "R", "orcid": "0000-0002-8850-7863", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/234ef51ed7854efb8bbadc3ce35bf7d9.json"}}, {"family": "Lindhagen", "given": "Lars", "initials": "L"}, {"family": "Loeb", "given": "Stacy", "initials": "S"}, {"family": "Styrke", "given": "Johan", "initials": "J"}, {"family": "Garmo", "given": "Hans", "initials": "H"}, {"family": "Stattin", "given": "P\u00e4r", "initials": "P"}], "type": "journal article", "published": "2021-12-23", "journal": {"title": "Scand J Urol", "issn": "2168-1813", "pages": "1-8", "issn-l": null}, "abstract": "Androgens facilitate entrance of the severe acute respiratory syndrome coronavirus 2 into respiratory epithelial cells, and male sex is associated with a higher risk of death from corona virus disease (COVID-19). Androgen deprivation therapy (ADT) could possibly improve COVID-19 outcomes.\n\nIn a case-control study nested in the Prostate Cancer data Base Sweden (PCBaSe) RAPID 2019, we evaluated the association between ADT and COVID-19 as registered cause of death in men with prostate cancer. Each case was matched to 50 controls by region. We used conditional logistic regression to adjust for confounders and also evaluated potential impact of residual confounding.\n\nWe identified 474 men who died from COVID-19 in March-December 2020. In crude analyses, ADT exposure was associated with an increased risk of COVID-19 death (odds ratio [OR] 5.05, 95% CI: 4.18-6.10); however, the OR was substantially attenuated after adjustment for age, comorbidity, prostate cancer characteristics at diagnosis, recent healthcare use, and indicators of advanced cancer (adjusted OR 1.25, 95% CI: 0.95-1.65). If adjustment has accounted for at least 85% of confounding, then the true effect could be no more than a 5% reduction of the odds for COVID-19 death.\n\nThe increased mortality from COVID-19 in men with prostate cancer treated with ADT was mainly related to high age, comorbidity, and more advanced prostate cancer. There was no evidence to support the hypothesis that ADT is associated with improved COVID-19 outcomes.", "doi": "10.1080/21681805.2021.2019304", "pmid": "34939533", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-03T15:35:02.365Z", "modified": "2022-01-03T15:35:42.285Z"}, {"entity": "publication", "iuid": "5a96c0779f7449aea420f70eef901728", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5a96c0779f7449aea420f70eef901728.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5a96c0779f7449aea420f70eef901728"}}, "title": "What now for Sweden and covid-19?", "authors": [{"family": "Paterlini", "given": "Marta", "initials": "M"}], "type": "journal article", "published": "2021-12-22", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "375", "pages": "n3081", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.n3081", "pmid": "34937690", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2022-01-03T15:33:31.328Z", "modified": "2022-01-03T15:33:31.344Z"}, {"entity": "publication", "iuid": "093ffa468c994870b232e6c8f9da47f6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/093ffa468c994870b232e6c8f9da47f6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/093ffa468c994870b232e6c8f9da47f6"}}, "title": "The Exposome and Immune Health in Times of the COVID-19 Pandemic.", "authors": [{"family": "Morales", "given": "Javier S", "initials": "JS"}, {"family": "Valenzuela", "given": "Pedro L", "initials": "PL", "orcid": "0000-0003-1730-3369", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0526f21ccb3c442085a7e77fd5ff49e9.json"}}, {"family": "Castillo-Garc\u00eda", "given": "Adri\u00e1n", "initials": "A"}, {"family": "Butrague\u00f1o", "given": "Javier", "initials": "J"}, {"family": "Jim\u00e9nez-Pav\u00f3n", "given": "David", "initials": "D", "orcid": "0000-0002-8977-4744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0b7642d758d4e2aa4f69df83a0c2c73.json"}}, {"family": "Carrera-Bastos", "given": "Pedro", "initials": "P"}, {"family": "Lucia", "given": "Alejandro", "initials": "A"}], "type": "journal article", "published": "2021-12-22", "journal": {"title": "Nutrients", "issn": "2072-6643", "volume": "14", "issue": "1", "issn-l": null}, "abstract": "Growing evidence supports the importance of lifestyle and environmental exposures-collectively referred to as the 'exposome'-for ensuring immune health. In this narrative review, we summarize and discuss the effects of the different exposome components (physical activity, body weight management, diet, sun exposure, stress, sleep and circadian rhythms, pollution, smoking, and gut microbiome) on immune function and inflammation, particularly in the context of the current coronavirus disease 2019 (COVID-19) pandemic. We highlight the potential role of 'exposome improvements' in the prevention-or amelioration, once established-of this disease as well as their effect on the response to vaccination. In light of the existing evidence, the promotion of a healthy exposome should be a cornerstone in the prevention and management of the COVID-19 pandemic and other eventual pandemics.", "doi": "10.3390/nu14010024", "pmid": "35010900", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "nu14010024"}], "notes": [], "created": "2022-01-13T21:07:19.748Z", "modified": "2022-01-13T21:07:21.095Z"}, {"entity": "publication", "iuid": "dd739d1768c84ea29a5623e9375eb5ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dd739d1768c84ea29a5623e9375eb5ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dd739d1768c84ea29a5623e9375eb5ca"}}, "title": "SARS-CoV-2 reactive and neutralizing antibodies discovered by single-cell sequencing of plasma cells and mammalian display.", "authors": [{"family": "Ehling", "given": "Roy A", "initials": "RA"}, {"family": "Weber", "given": "C\u00e9dric R", "initials": "CR"}, {"family": "Mason", "given": "Derek M", "initials": "DM"}, {"family": "Friedensohn", "given": "Simon", "initials": "S"}, {"family": "Wagner", "given": "Bastian", "initials": "B"}, {"family": "Bieberich", "given": "Florian", "initials": "F"}, {"family": "Kapetanovic", "given": "Edo", "initials": "E"}, {"family": "Vazquez-Lombardi", "given": "Rodrigo", "initials": "R"}, {"family": "Di Roberto", "given": "Rapha\u00ebl B", "initials": "RB"}, {"family": "Hong", "given": "Kai-Lin", "initials": "KL"}, {"family": "Wagner", "given": "Camille", "initials": "C"}, {"family": "Pataia", "given": "Michele", "initials": "M"}, {"family": "Overath", "given": "Max D", "initials": "MD"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Yermanos", "given": "Alexander", "initials": "A"}, {"family": "Cuny", "given": "Andreas P", "initials": "AP"}, {"family": "Savic", "given": "Miodrag", "initials": "M"}, {"family": "Rudolf", "given": "Fabian", "initials": "F"}, {"family": "Reddy", "given": "Sai T", "initials": "ST"}], "type": "journal article", "published": "2021-12-22", "journal": {"title": "Cell Rep", "issn": "2211-1247", "pages": "110242", "issn-l": null}, "abstract": "Characterization of COVID-19 antibodies has largely focused on memory B cells; however, it is the antibody-secreting plasma cells that are directly responsible for the production of serum antibodies, which play a critical role in resolving SARS-CoV-2 infection. Little is known about the specificity of plasma cells, largely because plasma cells lack surface antibody expression, thereby complicating their screening. Here, we describe a technology pipeline that integrates single-cell antibody repertoire sequencing and mammalian display to interrogate the specificity of plasma cells from 16 convalescent patients. Single-cell sequencing allows us to profile antibody repertoire features and identify expanded clonal lineages. Mammalian display screening is used to reveal that 43 antibodies (of 132 candidates) derived from expanded plasma cell lineages are specific to SARS-CoV-2 antigens, including antibodies with high affinity to the SARS-CoV-2 receptor-binding domain (RBD) that exhibit potent neutralization and broad binding to the RBD of SARS-CoV-2 variants (of concern/interest).", "doi": "10.1016/j.celrep.2021.110242", "pmid": "34998467", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2211-1247(21)01751-4"}, {"db": "URL", "key": "https://github.com/LSSI-ETH", "description": "https://github.com/LSSI-ETH"}, {"db": "URL", "key": "https://dx.doi.org/10.17632/rvd7999gk4.1", "description": "Fully annotated extracted antibody sequences and single cell results"}, {"db": "BioProject", "key": "http://www.ncbi.nlm.nih.gov/bioproject/782883", "description": "http://www.ncbi.nlm.nih.gov/bioproject/782883"}, {"db": "URL", "key": "http://www.ncbi.nlm.nih.gov/bioproject/782992", "description": "http://www.ncbi.nlm.nih.gov/bioproject/782992"}], "notes": [], "created": "2022-01-10T11:52:01.582Z", "modified": "2022-01-10T11:54:42.355Z"}, {"entity": "publication", "iuid": "d06ea09961354e1eb33ebe12c661c146", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d06ea09961354e1eb33ebe12c661c146.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d06ea09961354e1eb33ebe12c661c146"}}, "title": "Characteristics and outcomes of patients with COVID-19 with and without prevalent hypertension: a multinational cohort study.", "authors": [{"family": "Reyes", "given": "Carlen", "initials": "C", "orcid": "0000-0001-8486-3265", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64ac81f77bd340b0a29d97ee85d1f5c8.json"}}, {"family": "Pistillo", "given": "Andrea", "initials": "A"}, {"family": "Fern\u00e1ndez-Bertol\u00edn", "given": "Sergio", "initials": "S"}, {"family": "Recalde", "given": "Martina", "initials": "M"}, {"family": "Roel", "given": "Elena", "initials": "E"}, {"family": "Puente", "given": "Diana", "initials": "D"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Blacketer", "given": "Clair", "initials": "C"}, {"family": "Lai", "given": "Lana", "initials": "L"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Ahmed", "given": "Waheed-Ui-Rahman", "initials": "WU"}, {"family": "Alser", "given": "Osaid", "initials": "O", "orcid": "0000-0001-6743-803X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c919eb8e21f74327b80f25eae0313eb6.json"}}, {"family": "Alghoul", "given": "Heba", "initials": "H", "orcid": "0000-0001-8234-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e3deb1abdf54088a29dee7675a18697.json"}}, {"family": "Areia", "given": "Carlos", "initials": "C", "orcid": "0000-0002-4668-7069", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7232f54be5df43f0b984d0117d88a054.json"}}, {"family": "Dawoud", "given": "Dalia", "initials": "D"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A", "orcid": "0000-0003-1202-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47f086bb6ccd49a2a5f11a32c06277c8.json"}}, {"family": "Valveny", "given": "Neus", "initials": "N"}, {"family": "de Maeztu", "given": "Gabriel", "initials": "G"}, {"family": "Sorl\u00ed Red\u00f3", "given": "Luisa", "initials": "L"}, {"family": "Martinez Roldan", "given": "Jordi", "initials": "J"}, {"family": "Lopez Montesinos", "given": "Inmaculada", "initials": "I"}, {"family": "Schilling", "given": "Lisa M", "initials": "LM"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Shah", "given": "Nigam", "initials": "N"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "DuVall", "given": "Scott L", "initials": "SL"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR", "orcid": "0000-0003-0621-1979", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d03ea51cfd6344d5a6469fef31e9f941.json"}}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Kostka", "given": "Kristin", "initials": "K", "orcid": "0000-0003-2595-8736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9675cf1b775341f6a3521c7dde950262.json"}}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T", "orcid": "0000-0002-8274-0357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11fd8deb257445e7a93a0a3098b246df.json"}}], "type": "journal article", "published": "2021-12-22", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "12", "pages": "e057632", "issn-l": "2044-6055"}, "abstract": "To characterise patients with and without prevalent hypertension and COVID-19 and to assess adverse outcomes in both inpatients and outpatients.\n\nThis is a retrospective cohort study using 15 healthcare databases (primary and secondary electronic healthcare records, insurance and national claims data) from the USA, Europe and South Korea, standardised to the Observational Medical Outcomes Partnership common data model. Data were gathered from 1 March to 31 October 2020.\n\nTwo non-mutually exclusive cohorts were defined: (1) individuals diagnosed with COVID-19 (diagnosed cohort) and (2) individuals hospitalised with COVID-19 (hospitalised cohort), and stratified by hypertension status. Follow-up was from COVID-19 diagnosis/hospitalisation to death, end of the study period or 30 days.\n\nDemographics, comorbidities and 30-day outcomes (hospitalisation and death for the 'diagnosed' cohort and adverse events and death for the 'hospitalised' cohort) were reported.\n\nWe identified 2 851 035 diagnosed and 563 708 hospitalised patients with COVID-19. Hypertension was more prevalent in the latter (ranging across databases from 17.4% (95% CI 17.2 to 17.6) to 61.4% (95% CI 61.0 to 61.8) and from 25.6% (95% CI 24.6 to 26.6) to 85.9% (95% CI 85.2 to 86.6)). Patients in both cohorts with hypertension were predominantly >50 years old and female. Patients with hypertension were frequently diagnosed with obesity, heart disease, dyslipidaemia and diabetes. Compared with patients without hypertension, patients with hypertension in the COVID-19 diagnosed cohort had more hospitalisations (ranging from 1.3% (95% CI 0.4 to 2.2) to 41.1% (95% CI 39.5 to 42.7) vs from 1.4% (95% CI 0.9 to 1.9) to 15.9% (95% CI 14.9 to 16.9)) and increased mortality (ranging from 0.3% (95% CI 0.1 to 0.5) to 18.5% (95% CI 15.7 to 21.3) vs from 0.2% (95% CI 0.2 to 0.2) to 11.8% (95% CI 10.8 to 12.8)). Patients in the COVID-19 hospitalised cohort with hypertension were more likely to have acute respiratory distress syndrome (ranging from 0.1% (95% CI 0.0 to 0.2) to 65.6% (95% CI 62.5 to 68.7) vs from 0.1% (95% CI 0.0 to 0.2) to 54.7% (95% CI 50.5 to 58.9)), arrhythmia (ranging from 0.5% (95% CI 0.3 to 0.7) to 45.8% (95% CI 42.6 to 49.0) vs from 0.4% (95% CI 0.3 to 0.5) to 36.8% (95% CI 32.7 to 40.9)) and increased mortality (ranging from 1.8% (95% CI 0.4 to 3.2) to 25.1% (95% CI 23.0 to 27.2) vs from 0.7% (95% CI 0.5 to 0.9) to 10.9% (95% CI 10.4 to 11.4)) than patients without hypertension.\n\nCOVID-19 patients with hypertension were more likely to suffer severe outcomes, hospitalisations and deaths compared with those without hypertension.", "doi": "10.1136/bmjopen-2021-057632", "pmid": "34937726", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-057632"}, {"db": "pmc", "key": "PMC8704062"}], "notes": [], "created": "2022-01-03T15:34:18.912Z", "modified": "2022-01-03T15:34:32.723Z"}, {"entity": "publication", "iuid": "87c62cac7b124fa7a08738b66eae598f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87c62cac7b124fa7a08738b66eae598f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87c62cac7b124fa7a08738b66eae598f"}}, "title": "Plasma Leptin Is Increased in Intensive Care Patients with COVID-19-An Investigation Performed in the PronMed-Cohort.", "authors": [{"family": "Larsson", "given": "Anders", "initials": "A", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2be858ab604743b72383dfdcd14689.json"}}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Eriksson", "given": "Mats", "initials": "M", "orcid": "0000-0002-3178-4210", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c90375295094966a51f9d17c275abb6.json"}}], "type": "journal article", "published": "2021-12-21", "journal": {"title": "Biomedicines", "issn": "2227-9059", "issn-l": null, "volume": "10", "issue": "1", "pages": null}, "abstract": "COVID-19 has shaken the world and intensive care units (ICU) have been challenged by numerous patients suffering from a previously unknown disease. Leptin is a polypeptide pleiotropic hormone, mainly expressed by adipocytes. It acts as a proinflammatory cytokine and is associated with several conditions, known to increase the risk of severe COVID-19. Very little is known about leptin in severe viral disorders. Plasma leptin was analyzed in 222 out of 229 patients with severe COVID-19 on admission to an ICU at Uppsala University Hospital, a tertiary care hospital in Sweden, and compared to plasma leptin in 25 healthy blood donors. COVID-19 was confirmed by positive PCR. Leptin levels were significantly higher in patients with COVID-19 (18.3 ng \u00d7 mL-1; IQR = 30.4), than in healthy controls (7.8 ng \u00d7 mL-1; IQR = 6.4). Women had significantly higher leptin values (22.9 ng \u00d7 mL-1; IQR = 29.8) than men (17.5 ng \u00d7 mL-1; IQR = 29.9). Mortality at 30 days was 23% but was not associated with increased leptin levels. Neither median duration of COVID-19 before admission to ICU (10 days; IQR = 4) or median length of ICU stay (8 days; IQR = 11) correlated with the plasma leptin levels. Leptin levels in COVID-19 were higher in females than in males. Both treatment (e.g., use of corticosteroids) and prophylaxis (vaccines) have been improved since the start of the COVID-19 pandemic, which may contribute to some difficulties in deciphering relations between COVID-19 and leptin.", "doi": "10.3390/biomedicines10010004", "pmid": "35052684", "labels": {"Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Biochemistry": null, "Funder: VR": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "biomedicines10010004"}], "notes": [], "created": "2022-01-26T10:22:24.166Z", "modified": "2022-02-08T19:22:23.653Z"}, {"entity": "publication", "iuid": "ef350c9ac7a04e84bc75cd86b285cc1e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef350c9ac7a04e84bc75cd86b285cc1e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef350c9ac7a04e84bc75cd86b285cc1e"}}, "title": "Considerations for COVID-19 management in reception centers for refugees, asylum seekers and migrants, Spain 2020.", "authors": [{"family": "Hoefer", "given": "Andreas", "initials": "A"}, {"family": "Pampaka", "given": "Despina", "initials": "D"}, {"family": "Castrillejo", "given": "Daniel", "initials": "D"}, {"family": "Luenga-Cabrera", "given": "Jos\u00e9", "initials": "J"}, {"family": "Paisi", "given": "Martha", "initials": "M"}, {"family": "Herrera-Le\u00f3n", "given": "Silvia", "initials": "S"}, {"family": "L\u00f3pez-Perea", "given": "Noem\u00ed", "initials": "N"}, {"family": "Del Diego-Salas", "given": "Jorge", "initials": "J"}], "type": "journal article", "published": "2021-12-21", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": null, "issue": null, "pages": null}, "abstract": "Shortly after the declaration of the COVID-19 pandemic, governments around the world were urged to leave no population behind. Following a COVID-19 risk evaluation in a refugee and asylum seekers reception center, in September 2020, we considered the priorities of managing COVID-19 in these settings. We encourage actions on four fronts to reduce the COVID-19 associated burden amongst these vulnerable populations based on our interviews, observations and recommendations: (i) decongestion, (ii) facilitated testing, (iii) screening for symptoms and (iv) targeted public health and risk communication.", "doi": "10.1016/j.ijid.2021.12.341", "pmid": "34952212", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)01240-6"}, {"db": "pmc", "key": "PMC8690219"}], "notes": [], "created": "2022-01-04T15:26:01.536Z", "modified": "2022-11-22T05:43:02.433Z"}, {"entity": "publication", "iuid": "1366fc55cc6947d495356d3d29942458", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1366fc55cc6947d495356d3d29942458.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1366fc55cc6947d495356d3d29942458"}}, "title": "Chaplain Leadership During COVID-19: An International Expert Panel.", "authors": [{"family": "Szilagyi", "given": "Csaba", "initials": "C", "orcid": "0000-0002-0413-3025", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d833cb5acf3f432395c8b03de5554f81.json"}}, {"family": "Vandenhoeck", "given": "Anne", "initials": "A", "orcid": "0000-0003-0479-6408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d02323e639d4c38acbe70795fe2f6db.json"}}, {"family": "Best", "given": "Megan C", "initials": "MC"}, {"family": "Desjardins", "given": "Cate Michelle", "initials": "CM", "orcid": "0000-0002-7928-3239", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c98b6cd4026249cdaffd63d17cf0d302.json"}}, {"family": "Drummond", "given": "David A", "initials": "DA"}, {"family": "Fitchett", "given": "George", "initials": "G"}, {"family": "Harrison", "given": "Simon", "initials": "S"}, {"family": "Haythorn", "given": "Trace", "initials": "T", "orcid": "0000-0001-7681-6522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/018d1123ea7c4a5e9b4886eb4a1052ab.json"}}, {"family": "Holmes", "given": "Cheryl", "initials": "C"}, {"family": "Muthert", "given": "Hanneke", "initials": "H", "orcid": "0000-0002-1975-6102", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2442aa919afa40669626e7f91ae961d8.json"}}, {"family": "Nuzum", "given": "Daniel", "initials": "D", "orcid": "0000-0002-9907-5680", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ef033373aa741dfab63209ec5238ff9.json"}}, {"family": "Verhoef", "given": "Joost H A", "initials": "JHA"}, {"family": "Willander", "given": "Erika", "initials": "E"}], "type": "journal article", "published": "2021-12-21", "journal": {"title": "J Pastoral Care Counsel", "issn": "2167-776X", "pages": "15423050211067724", "issn-l": null}, "abstract": "Chaplain leadership may have played a pivotal role in shaping chaplains' roles in health care amidst the COVID-19 pandemic. We convened an international expert panel to identify expert perception on key chaplain leadership factors. Six leadership themes of professional confidence, engaging and trust-building with executives, decision-making, innovation and creativity, building integrative and trusting connections with colleagues, and promoting cultural competencies emerged as central to determining chaplains' integration, perceived value, and contributions during the pandemic.", "doi": "10.1177/15423050211067724", "pmid": "34931932", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-03T15:30:43.220Z", "modified": "2022-01-03T15:30:43.448Z"}, {"entity": "publication", "iuid": "9bec6670580f4b5ebfa595be1ce83f4a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9bec6670580f4b5ebfa595be1ce83f4a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9bec6670580f4b5ebfa595be1ce83f4a"}}, "title": "The COVID-19 pandemic as experienced by adults with congenital heart disease from Belgium, Norway, and South Korea: impact on life domains, patient-reported outcomes, and experiences with care.", "authors": [{"family": "Moons", "given": "Philip", "initials": "P", "orcid": "0000-0002-8609-4516", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c7081af91424589a389e04745224849.json"}}, {"family": "Goossens", "given": "Eva", "initials": "E", "orcid": "0000-0003-3421-5256", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3869f53db0f542ac9c1ddf2a2527d2dc.json"}}, {"family": "Luyckx", "given": "Koen", "initials": "K", "orcid": "0000-0001-8862-5598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/794e7a8d0d2f4ead85fffcb95e054be4.json"}}, {"family": "Kovacs", "given": "Adrienne H", "initials": "AH", "orcid": "0000-0002-2687-0384", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/efc671a612194680a5db5e0bf04cf1d9.json"}}, {"family": "Andresen", "given": "Brith", "initials": "B", "orcid": "0000-0003-4359-9757", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/127245033cae4fc59d8eaeb693b52064.json"}}, {"family": "Moon", "given": "Ju Ryoung", "initials": "JR", "orcid": "0000-0002-4285-0295", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f415f05186a4935bc3ddc3de52059f9.json"}}, {"family": "Van De Bruaene", "given": "Alexander", "initials": "A", "orcid": "0000-0002-0469-8640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/603e48f2c9284953a674b3bae0392d1d.json"}}, {"family": "Rassart", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8535-1499", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d560e6e869849f6a9a8b23cb6765795.json"}}, {"family": "Van Bulck", "given": "Liesbet", "initials": "L", "orcid": "0000-0001-8975-4455", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bfadcaac546b4a818af2651cef4d0973.json"}}, {"family": "APPROACH-IS II consortium and ISACHD\n", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-20", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "issn-l": null}, "abstract": "The coronavirus disease-2019 (COVID-19) pandemic poses significant challenges to many groups within societies, and especially for people with chronic health conditions. It is, however, unknown whether and how the pandemic has thus far affected the physical and mental health of patient populations. Therefore, we investigated how the pandemic affected the lives of adults with congenital heart disease (CHD), compared pre- and peri-pandemic patient-reported outcome measures (PROMs) and a patient-reported experience measure (PREM), and investigated whether having had COVID-19 impacted pre-/peri-pandemic differences of the PROMs and PREM.\n\nAs part of the ongoing APPROACH-IS II project, we longitudinally surveyed 716 adults with CHD from Belgium, Norway, and South Korea. Pre-pandemic measures were administered from August 2019 to February 2020 and the peri-pandemic surveys were completed September 2020-April 2021. The majority of patients indicated that their social lives (80%), mental health (58%), and professional lives/education (51%) were negatively impacted by the pandemic. Patients felt worried (65%), were afraid (55%), reported the pandemic felt 'close' to them (53%), and were stressed (52%). However, differences between pre- and peri-pandemic scores on the PROMs and PREM were negligibly small (Cohen's d < 0.20). Across measures, 5.8-15.8% of patients demonstrated changes (improved or worsened scores) that exceeded the minimal clinically important difference. There were no difference-in-differences for PROMs and PREM between patients who did vs. did not have COVID-19.\n\nAlthough the COVID-19 pandemic has been disruptive in many ways, pre- to peri-pandemic changes in PROMs and PREM of adults with CHD were negligibly small.", "doi": "10.1093/eurjcn/zvab120", "pmid": "34927192", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6470369"}], "notes": [], "created": "2022-01-03T15:26:00.354Z", "modified": "2022-01-03T15:26:00.655Z"}, {"entity": "publication", "iuid": "741cface6f554bdfb3637d2cb1c2f4c7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/741cface6f554bdfb3637d2cb1c2f4c7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/741cface6f554bdfb3637d2cb1c2f4c7"}}, "title": "Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor.", "authors": [{"family": "Capraz", "given": "T\u00fcmay", "initials": "T", "orcid": "0000-0002-2547-067X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/16b4b4685c774fa394868d772e33e1a0.json"}}, {"family": "Kienzl", "given": "Nikolaus F", "initials": "NF", "orcid": "0000-0001-8057-3930", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00ccebd4f3c34f38b227a2ad414f9dfb.json"}}, {"family": "Laurent", "given": "Elisabeth", "initials": "E", "orcid": "0000-0002-5234-5524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a18c078a3654424b48790ac3409a684.json"}}, {"family": "Perthold", "given": "Jan W", "initials": "JW", "orcid": "0000-0002-8575-0278", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a40db3855af4c39ae1958e99072117a.json"}}, {"family": "F\u00f6derl-H\u00f6benreich", "given": "Esther", "initials": "E", "orcid": "0000-0003-2066-1036", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a769b59ed6e74abca396b6bb69461548.json"}}, {"family": "Gr\u00fcnwald-Gruber", "given": "Clemens", "initials": "C", "orcid": "0000-0002-6097-8348", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/065d1d48a41b4bd6ae83d28277037bea.json"}}, {"family": "Maresch", "given": "Daniel", "initials": "D"}, {"family": "Monteil", "given": "Vanessa", "initials": "V", "orcid": "0000-0002-2652-5695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8ba8a0b1af6423b9cba0fc4bb3177cd.json"}}, {"family": "Niederh\u00f6fer", "given": "Janine", "initials": "J"}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G", "orcid": "0000-0001-7035-7038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70afca1611904e419eca43bde2d681be.json"}}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Zatloukal", "given": "Kurt", "initials": "K", "orcid": "0000-0001-5299-7218", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6a34a836db947d0a327f197a5f938fb.json"}}, {"family": "Mach", "given": "Lukas", "initials": "L", "orcid": "0000-0001-9013-5408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e58ab479be1e4abd9f95f0c5737f280b.json"}}, {"family": "Penninger", "given": "Josef M", "initials": "JM", "orcid": "0000-0002-8194-3777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e56aaa008524272bf252df804e06991.json"}}, {"family": "Oostenbrink", "given": "Chris", "initials": "C", "orcid": "0000-0002-4232-2556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37566a0341cf4fd38366e43218cffd23.json"}}, {"family": "Stadlmann", "given": "Johannes", "initials": "J", "orcid": "0000-0001-5693-6690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab12a13b3ddd442588c1c9bda683d9ee.json"}}], "type": "journal article", "published": "2021-12-20", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "10", "issn-l": null}, "abstract": "Infection and viral entry of SARS-CoV-2 crucially depends on the binding of its Spike protein to angiotensin converting enzyme 2 (ACE2) presented on host cells. Glycosylation of both proteins is critical for this interaction. Recombinant soluble human ACE2 can neutralize SARS-CoV-2 and is currently undergoing clinical tests for the treatment of COVID-19. We used 3D structural models and molecular dynamics simulations to define the ACE2 N-glycans that critically influence Spike-ACE2 complex formation. Engineering of ACE2 N-glycosylation by site-directed mutagenesis or glycosidase treatment resulted in enhanced binding affinities and improved virus neutralization without notable deleterious effects on the structural stability and catalytic activity of the protein. Importantly, simultaneous removal of all accessible N-glycans from recombinant soluble human ACE2 yields a superior SARS-CoV-2 decoy receptor with promise as effective treatment for COVID-19 patients.", "doi": "10.7554/eLife.73641", "pmid": "34927585", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8730730"}, {"db": "pii", "key": "73641"}], "notes": [], "created": "2022-01-03T15:26:30.313Z", "modified": "2023-06-19T14:37:25.873Z"}, {"entity": "publication", "iuid": "b5b248ae72da40448398da21a0a9cf85", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5b248ae72da40448398da21a0a9cf85.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5b248ae72da40448398da21a0a9cf85"}}, "title": "Immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in older residents of a long-term care facility: relation with age, frailty and prior infection status.", "authors": [{"family": "Seiffert", "given": "Piotr", "initials": "P", "orcid": "0000-0001-7987-5640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3350920951f422eac0c2667c7aae4c9.json"}}, {"family": "Konka", "given": "Adam", "initials": "A"}, {"family": "Kasperczyk", "given": "Janusz", "initials": "J", "orcid": "0000-0002-6945-1200", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f0d95aa2fe1446bafb2ed67696b4146.json"}}, {"family": "Kawa", "given": "Jacek", "initials": "J", "orcid": "0000-0002-2804-7885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4126c74290704df495c610f0b5646d97.json"}}, {"family": "Lejawa", "given": "Mateusz", "initials": "M", "orcid": "0000-0002-1228-7534", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e36f837cd6054b2592d7b7d5dbd57a03.json"}}, {"family": "Ma\u015blanka-Seiffert", "given": "Barbara", "initials": "B", "orcid": "0000-0002-5524-0760", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2529abd1474e49d295c477ffeb767c36.json"}}, {"family": "Zembala-John", "given": "Joanna", "initials": "J", "orcid": "0000-0001-5787-3820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91acb29e031941d6b33a968d7e57cb3e.json"}}, {"family": "Bugdol", "given": "Monika", "initials": "M", "orcid": "0000-0002-6917-0441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/38995f1aae584d2182028ef11a89da3a.json"}}, {"family": "Romanik", "given": "Ma\u0142gorzata", "initials": "M", "orcid": "0000-0003-0377-9833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a748240d8bd48b5a126909ab565022d.json"}}, {"family": "Bu\u0142dak", "given": "Rafa\u0142", "initials": "R", "orcid": "0000-0002-0405-0596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44aad3c48a484fd1bf10681a361b795d.json"}}, {"family": "Marcisz", "given": "Czes\u0142aw", "initials": "C", "orcid": "0000-0001-9313-1007", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed63975fc6ca41e89b876d4df2408df3.json"}}, {"family": "Derejczyk", "given": "Jaros\u0142aw", "initials": "J"}, {"family": "Religa", "given": "Dorota", "initials": "D", "orcid": "0000-0003-4583-4570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e2c968ecffa4c638126d6d8d4a0dbd9.json"}}], "type": "journal article", "published": "2021-12-19", "journal": {"title": "Biogerontology", "issn": "1573-6768", "issn-l": null}, "abstract": "Clinical and biological assessment of the COVID-19 vaccine efficacy in the frail population is of crucial importance. The study focuses on measuring the levels of anti-SARS-CoV-2 IgG antibodies before and after BNT162b2 mRNA COVID-19 vaccination among long-term care facility (LTCF) elderly residents. We conducted a prospective, single-center, observational study among LTCF residents. The study protocol was based on three blood sample acquisitions: first taken at baseline-5 days before the first dose of the vaccine, second-20 days after the first dose, and third-12 days after the second shot of the vaccine. The comparison was made for two cohorts: patients with and without prior COVID-19 infection. The data was collected from January to March 2021. A total number of 78 LTCF residents (55 women and 23 men) aged 62-104, 85.72 \u00b1 7.59 years (mean \u00b1 SD), were enrolled in the study. All study participants were investigated for the presence of SARS-CoV-2 anti-spike (S) protein IgG, using a chemiluminescent immunoassay. Frailty was assessed with the Clinical Frailty Scale. Among elderly COVID-19 survivors in LTCF, a single dose of vaccine significantly increased anti-SARS-CoV-2 IgG antibody levels. IgG concentration after a single and double dose was comparable, which may suggest that elderly COVID-19 survivors do not require a second dose of vaccine. For residents without a previous history of COVID-19, two doses are needed to achieve an effective serological response. The level of anti-SARS-CoV-2 IgG antibodies after vaccination with BNT162b2 mRNA COVID-19 did not correlate with the frailty and age of the studied individuals.", "doi": "10.1007/s10522-021-09944-9", "pmid": "34923608", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10522-021-09944-9"}], "notes": [], "created": "2021-12-20T08:32:52.960Z", "modified": "2021-12-20T08:32:53.315Z"}, {"entity": "publication", "iuid": "625ae786f98c4461aea160f935df1fb6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/625ae786f98c4461aea160f935df1fb6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/625ae786f98c4461aea160f935df1fb6"}}, "title": "The impact of COVID-19 on oncology professionals-one year on: lessons learned from the ESMO Resilience Task Force survey series.", "authors": [{"family": "Lim", "given": "K H J", "initials": "KHJ"}, {"family": "Murali", "given": "K", "initials": "K"}, {"family": "Thorne", "given": "E", "initials": "E"}, {"family": "Punie", "given": "K", "initials": "K"}, {"family": "Kamposioras", "given": "K", "initials": "K"}, {"family": "Oing", "given": "C", "initials": "C"}, {"family": "O'Connor", "given": "M", "initials": "M"}, {"family": "\u00c9lez", "given": "E", "initials": "E"}, {"family": "Amaral", "given": "T", "initials": "T"}, {"family": "Garrido", "given": "P", "initials": "P"}, {"family": "Lambertini", "given": "M", "initials": "M"}, {"family": "Devnani", "given": "B", "initials": "B"}, {"family": "Westphalen", "given": "C B", "initials": "CB"}, {"family": "Morgan", "given": "G", "initials": "G"}, {"family": "Haanen", "given": "J B A G", "initials": "JBAG"}, {"family": "Hardy", "given": "C", "initials": "C"}, {"family": "Banerjee", "given": "S", "initials": "S"}], "type": "journal article", "published": "2021-12-17", "journal": {"title": "ESMO Open", "issn": "2059-7029", "volume": "7", "issue": "1", "pages": "100374", "issn-l": null}, "abstract": "COVID-19 has had a significant impact on the well-being and job performance of oncology professionals globally. The European Society for Medical Oncology (ESMO) Resilience Task Force collaboration set out to investigate and monitor well-being since COVID-19 in relation to work, lifestyle and support factors in oncology professionals 1 year on since the start of the pandemic.\n\nAn online, anonymous survey was conducted in February/March 2021 (Survey III). Key outcome variables included risk of poor well-being or distress (expanded Well-Being Index), feeling burnout (single item from expanded Well-Being Index), and job performance since COVID-19. Longitudinal analysis of responses to the series of three surveys since COVID-19 was carried out, and responses to job demands and resources questions were interrogated. SPSS V.26.0/V.27.0 and GraphPad Prism V9.0 were used for statistical analyses.\n\nResponses from 1269 participants from 104 countries were analysed in Survey III: 55% (n = 699/1269) female, 54% (n = 686/1269) >40 years, and 69% (n = 852/1230) of white ethnicity. There continues to be an increased risk of poor well-being or distress (n = 464/1169, 40%) and feeling burnout (n = 660/1169, 57%) compared with Survey I (25% and 38% respectively, P < 0.0001), despite improved job performance. Compared with the initial period of the pandemic, more participants report feeling overwhelmed with workload (45% versus 29%, P < 0.0001). There remain concerns about the negative impact of the pandemic on career development/training (43%), job security (37%). and international fellowship opportunities (76%). Alarmingly, 25% (n = 266/1086) are considering changing their future career with 38% (n = 100/266) contemplating leaving the profession.\n\nOncology professionals continue to face increased job demands. There is now significant concern regarding potential attrition in the oncology workforce. National and international stakeholders must act immediately and work closely with oncology professionals to draw up future-proof recovery plans.", "doi": "10.1016/j.esmoop.2021.100374", "pmid": "35007996", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2059-7029(21)00336-7"}, {"db": "pmc", "key": "PMC8677468"}], "notes": [], "created": "2022-01-13T21:09:07.089Z", "modified": "2022-01-13T21:09:07.104Z"}, {"entity": "publication", "iuid": "fe20006bef944898a5ba6fb7a08430f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fe20006bef944898a5ba6fb7a08430f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fe20006bef944898a5ba6fb7a08430f8"}}, "title": "Predicting regional COVID-19 hospital admissions in Sweden using mobility data.", "authors": [{"family": "Gerlee", "given": "Philip", "initials": "P", "orcid": "0000-0001-8503-0177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ba426c1ab741e781d2b9cd09a0b830.json"}}, {"family": "Karlsson", "given": "Julia", "initials": "J"}, {"family": "Fritzell", "given": "Ingrid", "initials": "I"}, {"family": "Brezicka", "given": "Thomas", "initials": "T"}, {"family": "Spreco", "given": "Armin", "initials": "A"}, {"family": "Timpka", "given": "Toomas", "initials": "T"}, {"family": "J\u00f6ud", "given": "Anna", "initials": "A", "orcid": "0000-0001-7192-4911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e038a5ce2f5a47bd89e7c221651a3d24.json"}}, {"family": "Lundh", "given": "Torbj\u00f6rn", "initials": "T"}], "type": "journal article", "published": "2021-12-17", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "24171", "issn-l": "2045-2322"}, "abstract": "The transmission of COVID-19 is dependent on social mixing, the basic rate of which varies with sociodemographic, cultural, and geographic factors. Alterations in social mixing and subsequent changes in transmission dynamics eventually affect hospital admissions. We employ these observations to model and predict regional hospital admissions in Sweden during the COVID-19 pandemic. We use an SEIR-model for each region in Sweden in which the social mixing is assumed to depend on mobility data from public transport utilisation and locations for mobile phone usage. The results show that the model could capture the timing of the first and beginning of the second wave of the pandemic 3 weeks in advance without any additional assumptions about seasonality. Further, we show that for two major regions of Sweden, models with public transport data outperform models using mobile phone usage. We conclude that a model based on routinely collected mobility data makes it possible to predict future hospital admissions for COVID-19 3 weeks in advance.", "doi": "10.1038/s41598-021-03499-y", "pmid": "34921175", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8683437"}, {"db": "pii", "key": "10.1038/s41598-021-03499-y"}], "notes": [], "created": "2021-12-20T08:33:34.441Z", "modified": "2023-06-19T14:58:56.449Z"}, {"entity": "publication", "iuid": "c1d3881f25114bf690e10d021c077a59", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1d3881f25114bf690e10d021c077a59.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1d3881f25114bf690e10d021c077a59"}}, "title": "Potential SARS-CoV-2 infectiousness among asymptomatic healthcare workers.", "authors": [{"family": "Pimenoff", "given": "Ville N", "initials": "VN", "orcid": "0000-0002-0813-7031", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6df74f265514d7b8fa216d9bad0ead6.json"}}, {"family": "Elfstr\u00f6m", "given": "Miriam", "initials": "M"}, {"family": "Conneryd Lundgren", "given": "Kalle", "initials": "K"}, {"family": "Klevebro", "given": "Susanna", "initials": "S", "orcid": "0000-0002-1261-6502", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e192d615f8648c0ae28b5ccaf1d6803.json"}}, {"family": "Melen", "given": "Erik", "initials": "E"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}], "type": "journal article", "published": "2021-12-17", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "12", "pages": "e0260453", "issn-l": "1932-6203"}, "abstract": "A majority of SARS-CoV-2 infections are transmitted from a minority of infected subjects, some of which may be symptomatic or pre-symptomatic. We aimed to quantify potential infectiousness among asymptomatic healthcare workers (HCWs) in relation to prior or later symptomatic disease. We previously (at the onset of the SARS-CoV-2 epidemic) performed a cohort study of SARS-CoV-2 infections among 27,000 healthcare workers (HCWs) at work in the capital region of Sweden. We performed both SARS-CoV-2 RT-PCR and serology. Furthermore, the cohort was comprehensively followed for sick leave, both before and after sampling. In the present report, we used the cohort database to quantify potential infectiousness among HCWs at work. Those who had sick leave either before or after sampling were classified as post-symptomatic or pre-symptomatic, whereas the virus-positive subjects with no sick leave were considered asymptomatic. About 0.2% (19/9449) of HCW at work were potentially infectious and pre-symptomatic (later had disease) and 0.17% (16/9449) were potentially infectious and asymptomatic (never had sick leave either before nor after sampling). Thus, 33% and 28% of all the 57 potentially infectious subjects were pre-symptomatic or asymptomatic, respectively. When a questionnaire was administered to HCWs with past infection, only 10,5% of HCWs had had no indication at all of having had SARS-CoV-2 infection (\"truly asymptomatic\"). Our findings provide a unique quantification of the different groups of asymptomatic, potentially infectious HCWs.", "doi": "10.1371/journal.pone.0260453", "pmid": "34919570", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-25144"}, {"db": "URL", "key": "https://doi.org/10.1371/journal.pone.0260453.s001", "description": "https://doi.org/10.1371/journal.pone.0260453.s001"}], "notes": [], "created": "2021-12-18T17:37:11.654Z", "modified": "2021-12-18T17:40:54.884Z"}, {"entity": "publication", "iuid": "92fce9aeea0f4e6d8dde3d2c05f4f4f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/92fce9aeea0f4e6d8dde3d2c05f4f4f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/92fce9aeea0f4e6d8dde3d2c05f4f4f2"}}, "title": "Nuclear receptors: from molecular mechanisms to therapeutics.", "authors": [{"family": "Frigo", "given": "Daniel E", "initials": "DE", "orcid": "0000-0002-0713-471X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9838d42de57e4631b568c08cb22415cb.json"}}, {"family": "Bondesson", "given": "Maria", "initials": "M"}, {"family": "Williams", "given": "Cecilia", "initials": "C"}], "type": "editorial", "published": "2021-12-17", "journal": {"title": "Essays Biochem", "issn": "1744-1358", "volume": "65", "issue": "6", "pages": "847-856", "issn-l": null}, "abstract": "Nuclear receptors are classically defined as ligand-activated transcription factors that regulate key functions in reproduction, development, and physiology. Humans have 48 nuclear receptors, which when dysregulated are often linked to diseases. Because most nuclear receptors can be selectively activated or inactivated by small molecules, they are prominent therapeutic targets. The basic understanding of this family of transcription factors was accelerated in the 1980s upon the cloning of the first hormone receptors. During the next 20 years, a deep understanding of hormone signaling was achieved that has translated to numerous clinical applications, such as the development of standard-of-care endocrine therapies for hormonally driven breast and prostate cancers. A 2004 issue of this journal reviewed progress on elucidating the structures of nuclear receptors and their mechanisms of action. In the current issue, we focus on the broad application of new knowledge in this field for therapy across diverse disease states including cancer, cardiovascular disease, various inflammatory diseases, the aging brain, and COVID-19.", "doi": "10.1042/EBC20210020", "pmid": "34825698", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "230306"}, {"db": "pmc", "key": "PMC8628184"}], "notes": [], "created": "2021-12-18T18:18:28.799Z", "modified": "2021-12-18T18:18:28.866Z"}, {"entity": "publication", "iuid": "5c11ae1352184b6f8745bef1b04f1249", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c11ae1352184b6f8745bef1b04f1249.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c11ae1352184b6f8745bef1b04f1249"}}, "title": "Fluvastatin mitigates SARS-CoV-2 infection in human lung cells.", "authors": [{"family": "Zapatero-Belinch\u00f3n", "given": "Francisco J", "initials": "FJ"}, {"family": "Moeller", "given": "Rebecca", "initials": "R"}, {"family": "Lasswitz", "given": "Lisa", "initials": "L"}, {"family": "van Ham", "given": "Marco", "initials": "M"}, {"family": "Becker", "given": "Miriam", "initials": "M"}, {"family": "Brogden", "given": "Graham", "initials": "G"}, {"family": "Rosendal", "given": "Ebba", "initials": "E"}, {"family": "Bi", "given": "Wenjie", "initials": "W"}, {"family": "Carriqu\u00ed-Madro\u00f1al", "given": "Bel\u00e9n", "initials": "B"}, {"family": "Islam", "given": "Koushikul", "initials": "K"}, {"family": "Lenman", "given": "Annasara", "initials": "A"}, {"family": "Gunesch", "given": "Antonia P", "initials": "AP"}, {"family": "Kirui", "given": "Jared", "initials": "J"}, {"family": "Pietschmann", "given": "Thomas", "initials": "T"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "J\u00e4nsch", "given": "Lothar", "initials": "L"}, {"family": "Gerold", "given": "Gisa", "initials": "G"}], "type": "journal article", "published": "2021-12-17", "journal": {"title": "iScience", "issn": "2589-0042", "issn-l": "2589-0042", "volume": "24", "issue": "12", "pages": "103469"}, "abstract": "Clinical data of patients suffering from COVID-19 indicates that statin therapy, used to treat hypercholesterolemia, is associated with a better disease outcome. Whether statins directly affect virus replication or influence the clinical outcome through modulation of immune responses is unknown. We therefore investigated the effect of statins on SARS-CoV-2 infection in human lung cells and found that only fluvastatin inhibited low and high pathogenic coronaviruses in vitro and ex vivo in a dose-dependent manner. Quantitative proteomics revealed that fluvastatin and other tested statins modulated the cholesterol synthesis pathway without altering innate antiviral immune responses in infected lung epithelial cells. However, fluvastatin treatment specifically downregulated proteins that modulate protein translation and viral replication. Collectively, these results support the notion that statin therapy poses no additional risk to individuals exposed to SARS-CoV-2 and that fluvastatin has a moderate beneficial effect on SARS-CoV-2 infection of human lung cells.", "doi": "10.1016/j.isci.2021.103469", "pmid": "34812415", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(21)01440-1"}, {"db": "pmc", "key": "PMC8599137"}], "notes": [], "created": "2021-11-26T13:23:20.647Z", "modified": "2022-02-08T19:22:50.309Z"}, {"entity": "publication", "iuid": "4eceb96b17c1499e9310bdcc0f425bc2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4eceb96b17c1499e9310bdcc0f425bc2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4eceb96b17c1499e9310bdcc0f425bc2"}}, "title": "Differential Effect of SARS-CoV-2 Spike Glycoprotein 1 on Human Bronchial and Alveolar Lung Mucosa Models: Implications for Pathogenicity.", "authors": [{"family": "Rahman", "given": "Mizanur", "initials": "M"}, {"family": "Irmler", "given": "Martin", "initials": "M"}, {"family": "Keshavan", "given": "Sandeep", "initials": "S", "orcid": "0000-0002-2403-4083", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ada27ca05f7448838ea73da4e78220a6.json"}}, {"family": "Introna", "given": "Micol", "initials": "M", "orcid": "0000-0002-5564-1994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f3b999bbb7a4a19969f3ee84273091a.json"}}, {"family": "Beckers", "given": "Johannes", "initials": "J", "orcid": "0000-0002-1038-7160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9add2aa14db44646a7be17d450c14da0.json"}}, {"family": "Palmberg", "given": "Lena", "initials": "L"}, {"family": "Johanson", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8759-9567", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb124bc8baaf4bf8a811a2ffa0abdf0d.json"}}, {"family": "Ganguly", "given": "Koustav", "initials": "K", "orcid": "0000-0001-8531-8154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58b2e0d7853a4b32920e54042e95061d.json"}}, {"family": "Upadhyay", "given": "Swapna", "initials": "S"}], "type": "journal article", "published": "2021-12-17", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "13", "issue": "12", "pages": null}, "abstract": "The SARS-CoV-2 spike protein mediates attachment of the virus to the host cell receptor and fusion between the virus and the cell membrane. The S1 subunit of the spike glycoprotein (S1 protein) contains the angiotensin converting enzyme 2 (ACE2) receptor binding domain. The SARS-CoV-2 variants of concern contain mutations in the S1 subunit. The spike protein is the primary target of neutralizing antibodies generated following infection, and constitutes the viral component of mRNA-based COVID-19 vaccines.\r\n\r\nTherefore, in this work we assessed the effect of exposure (24 h) to 10 nM SARS-CoV-2 recombinant S1 protein on physiologically relevant human bronchial (bro) and alveolar (alv) lung mucosa models cultured at air-liquid interface (ALI) (n = 6 per exposure condition). Corresponding sham exposed samples served as a control. The bro-ALI model was developed using primary bronchial epithelial cells and the alv-ALI model using representative type II pneumocytes (NCI-H441).\r\n\r\nExposure to S1 protein induced the surface expression of ACE2, toll like receptor (TLR) 2, and TLR4 in both bro-ALI and alv-ALI models. Transcript expression analysis identified 117 (bro-ALI) and 97 (alv-ALI) differentially regulated genes (p \u2264 0.01). Pathway analysis revealed enrichment of canonical pathways such as interferon (IFN) signaling, influenza, coronavirus, and anti-viral response in the bro-ALI. Secreted levels of interleukin (IL) 4 and IL12 were significantly (p < 0.05) increased, whereas IL6 decreased in the bro-ALI. In the case of alv-ALI, enriched terms involving p53, APRIL (a proliferation-inducing ligand) tight junction, integrin kinase, and IL1 signaling were identified. These terms are associated with lung fibrosis. Further, significantly (p < 0.05) increased levels of secreted pro-inflammatory cytokines IFN\u03b3, IL1\ua7b5, IL2, IL4, IL6, IL8, IL10, IL13, and tumor necrosis factor alpha were detected in alv-ALI, whereas IL12 was decreased. Altered levels of these cytokines are also associated with lung fibrotic response.\r\n\r\nIn conclusion, we observed a typical anti-viral response in the bronchial model and a pro-fibrotic response in the alveolar model. The bro-ALI and alv-ALI models may serve as an easy and robust platform for assessing the pathogenicity of SARS-CoV-2 variants of concern at different lung regions.", "doi": "10.3390/v13122537", "pmid": "34960806", "labels": {"Category: Biochemistry": null, "Category: Vaccines": null, "Type: Journal article": null, "Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "v13122537"}, {"db": "pmc", "key": "PMC8708014"}, {"db": "URL", "key": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE185657", "description": "Gene Expression Omnibus database at NCBI (GSE185657)."}, {"db": "URL", "key": "https://www.mdpi.com/article/10.3390/v13122537/s1,", "description": "Supplementary material"}], "notes": [], "created": "2022-01-04T15:11:12.348Z", "modified": "2022-01-04T15:17:02.253Z"}, {"entity": "publication", "iuid": "7a685b9a808d41ba8d4943943ba9679f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a685b9a808d41ba8d4943943ba9679f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a685b9a808d41ba8d4943943ba9679f"}}, "title": "COVID-19 and Hygiene Hypothesis: increment of the Inflammatory Bowel Diseases in next generation?", "authors": [{"family": "Shahrbaf", "given": "Mohammad Amin", "initials": "MA"}, {"family": "Hassan", "given": "Moustapha", "initials": "M"}, {"family": "Vosough", "given": "Massoud", "initials": "M"}], "type": "editorial", "published": "2021-12-17", "journal": {"title": "Expert Rev Gastroenterol Hepatol", "issn": "1747-4132", "issn-l": null}, "abstract": null, "doi": "10.1080/17474124.2022.2020647", "pmid": "34919489", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-12-18T17:41:19.125Z", "modified": "2021-12-18T17:41:19.137Z"}, {"entity": "publication", "iuid": "dbfbeda66edb44c19af79e0644236fff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dbfbeda66edb44c19af79e0644236fff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dbfbeda66edb44c19af79e0644236fff"}}, "title": "Age-Stratified Risk of Cerebral Venous Sinus Thrombosis After SARS-CoV-2 Vaccination.", "authors": [{"family": "Krzywicka", "given": "Katarzyna", "initials": "K", "orcid": "0000-0002-9478-0401", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fca2d6da76f7470d8b22079b153956d4.json"}}, {"family": "van de Munckhof", "given": "Anita", "initials": "A"}, {"family": "S\u00e1nchez van Kammen", "given": "Mayte", "initials": "M", "orcid": "0000-0001-5614-9689", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae4f548088eb4c099837e35267755c0b.json"}}, {"family": "Heldner", "given": "Mirjam R", "initials": "MR", "orcid": "0000-0002-3594-2159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8280f8c6ea3a486abae8acc6aa491985.json"}}, {"family": "Jood", "given": "Katarina", "initials": "K"}, {"family": "Lindgren", "given": "Erik", "initials": "E", "orcid": "0000-0002-7628-5044", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e973b3c74ff4e5cba42da605a13bc61.json"}}, {"family": "Tatlisumak", "given": "Turgut", "initials": "T"}, {"family": "Putaala", "given": "Jukka", "initials": "J", "orcid": "0000-0002-6630-6104", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1930f3c097044b3a00d888744dab332.json"}}, {"family": "Kremer Hovinga", "given": "Johanna A", "initials": "JA", "orcid": "0000-0002-1300-7135", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f84022d8c60647929b2d7c45fa2e3849.json"}}, {"family": "Middeldorp", "given": "Saskia", "initials": "S"}, {"family": "Levi", "given": "Marcel M", "initials": "MM"}, {"family": "Cordonnier", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-5697-6892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba080d69348640eb90fba290f58fee11.json"}}, {"family": "Arnold", "given": "Marcel", "initials": "M"}, {"family": "Zwinderman", "given": "Aeilko H", "initials": "AH"}, {"family": "Ferro", "given": "Jos\u00e9 M", "initials": "JM"}, {"family": "Coutinho", "given": "Jonathan M", "initials": "JM", "orcid": "0000-0002-8284-982X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98cadafdcc044688bab25a3d7f9562b9.json"}}, {"family": "Aguiar de Sousa", "given": "Diana", "initials": "D"}], "type": "journal article", "published": "2021-12-17", "journal": {"title": "Neurology", "issn": "1526-632X", "issn-l": "0028-3878"}, "abstract": "Cerebral Venous Sinus Thrombosis (CVST) as a part of the thrombosis and thrombocytopenia syndrome is a rare adverse drug reaction of SARS-CoV-2 vaccination. Estimated background rate of CVST with thrombocytopenia is 0.1 per million per month. We assessed the age-stratified risk of CVST with and without thrombocytopenia after SARS-CoV-2 vaccination.\n\nWe estimated the absolute risk of CVST with and without thrombocytopenia within 28 days of first dose of four SARS-CoV-2 vaccinations, using data from the European Medicines Agency's EudraVigilance database (until 13 June 2021). As a denominator, we used data on vaccine delivery from 31 European countries. For 22.8 million adults from 25 countries, we estimated the absolute risk of CVST after the first dose of ChAdOx1 nCov-19 per age category.\n\nThe absolute risk of CVST within 28 days of first dose vaccination was 7.5 (95%CI 6.9-8.3), 0.7 (95%CI 0.2-2.4), 0.6 (95%CI 0.5-0.7) and 0.6 (95%CI 0.3-1.1) per million of first doses of ChAdOx1 nCov-19, Ad26.COV2.S, BNT162b2 and mRNA-1273, respectively. The absolute risk of CVST with thrombocytopenia within 28 days of first dose vaccination was 4.4 (95%CI 3.9-4.9), 0.7 (95%CI 0.2-2.4), 0.0 (95%CI 0.0-0.1) and 0.0 (95%CI 0.0-0.2) per million of first doses of ChAdOx1 nCov-19, Ad26.COV2.S, BNT162b2 and mRNA-1273, respectively. In recipients of ChAdOx1 nCov-19, the absolute risk of CVST, both with and without thrombocytopenia, was the highest in the 18-24 years age group (7.3 per million, 95%CI 2.8-18.8 and 3.7 per million, 95%CI 1.0-13.3, respectively). The risk of CVST with thrombocytopenia in ChAdOx1 nCov-19 recipients was the lowest in the age group\u226570 years (0.2, 95%CI 0.0-1.3). Age <60 compared to \u226560 was a predictor for CVST with thrombocytopenia (incidence rate ratio 5.79; 95%CI 2.98-11.24, p<0.001).\n\nThe risk of CVST with thrombocytopenia within 28 days of first dose vaccination with ChAdOx1 nCov-19 was higher in younger age groups. The risk of CVST with thrombocytopenia was slightly increased in patients receiving Ad26.COV2.S, compared with the estimated background risk. The risk of CVST with thrombocytopenia was not increased in recipients of SARS-CoV-2 mRNA vaccines.", "doi": "10.1212/WNL.0000000000013148", "pmid": "34921101", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "WNL.0000000000013148"}], "notes": [], "created": "2021-12-20T08:34:08.337Z", "modified": "2021-12-20T08:34:28.616Z"}, {"entity": "publication", "iuid": "a8981553df5d4274aaf529cd2b45a7f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8981553df5d4274aaf529cd2b45a7f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8981553df5d4274aaf529cd2b45a7f4"}}, "title": "", "authors": [{"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Fortea", "given": "Lydia", "initials": "L"}, {"family": "Pomarol-Clotet", "given": "Edith", "initials": "E"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Fullana", "given": "Miquel \u00c0ngel", "initials": "M\u00c0"}, {"family": "Solanes", "given": "Aleix", "initials": "A"}], "type": "case reports", "published": "2021-12-17", "journal": {"title": "Rev Psiquiatr Salud Ment", "issn": "1989-4600", "issn-l": null}, "abstract": null, "doi": "10.1016/j.rpsm.2021.12.004", "pmid": "34934465", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1888-9891(21)00134-8"}, {"db": "pmc", "key": "PMC8679503"}], "notes": [], "created": "2022-01-03T15:32:31.237Z", "modified": "2022-01-03T15:32:31.274Z"}, {"entity": "publication", "iuid": "05e8d837a24143c3978edafe2c1bf029", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/05e8d837a24143c3978edafe2c1bf029.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/05e8d837a24143c3978edafe2c1bf029"}}, "title": "Privacy Personas for IoT-Based Health Research: A Privacy Calculus Approach.", "authors": [{"family": "Maus", "given": "Benjamin", "initials": "B"}, {"family": "Olsson", "given": "Carl Magnus", "initials": "CM"}, {"family": "Salvi", "given": "Dario", "initials": "D"}], "type": "journal article", "published": "2021-12-16", "journal": {"title": "Front Digit Health", "issn": "2673-253X", "volume": "3", "pages": "675754", "issn-l": null}, "abstract": "The reliance on data donation from citizens as a driver for research, known as citizen science, has accelerated during the Sars-Cov-2 pandemic. An important enabler of this is Internet of Things (IoT) devices, such as mobile phones and wearable devices, that allow continuous data collection and convenient sharing. However, potentially sensitive health data raises privacy and security concerns for citizens, which research institutions and industries must consider. In e-commerce or social network studies of citizen science, a privacy calculus related to user perceptions is commonly developed, capturing the information disclosure intent of the participants. In this study, we develop a privacy calculus model adapted for IoT-based health research using citizen science for user engagement and data collection. Based on an online survey with 85 participants, we make use of the privacy calculus to analyse the respondents' perceptions. The emerging privacy personas are clustered and compared with previous research, resulting in three distinct personas which can be used by designers and technologists who are responsible for developing suitable forms of data collection. These are the 1) Citizen Science Optimist, the 2) Selective Data Donor, and the 3) Health Data Controller. Together with our privacy calculus for citizen science based digital health research, the three privacy personas are the main contributions of this study.", "doi": "10.3389/fdgth.2021.675754", "pmid": "34977856", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8716597"}], "notes": [], "created": "2022-01-04T14:43:51.211Z", "modified": "2022-01-04T14:43:51.251Z"}, {"entity": "publication", "iuid": "e070d5249b4e439f89b74961ed0f16fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e070d5249b4e439f89b74961ed0f16fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e070d5249b4e439f89b74961ed0f16fa"}}, "title": "Mechanistic Studies of an Automated Lipid Nanoparticle Reveal Critical Pharmaceutical Properties Associated with Enhanced mRNA Functional Delivery In Vitro and In Vivo.", "authors": [{"family": "Cui", "given": "Lili", "initials": "L", "orcid": "0000-0002-0668-2837", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a298a8143c1042e3a9bf00b0bc6dadd8.json"}}, {"family": "Hunter", "given": "Morag R", "initials": "MR"}, {"family": "Sonzini", "given": "Silvia", "initials": "S"}, {"family": "Pereira", "given": "Sara", "initials": "S"}, {"family": "Romanelli", "given": "Steven M", "initials": "SM"}, {"family": "Liu", "given": "Kai", "initials": "K"}, {"family": "Li", "given": "Weimin", "initials": "W"}, {"family": "Liang", "given": "Lihuan", "initials": "L"}, {"family": "Yang", "given": "Bin", "initials": "B"}, {"family": "Mahmoudi", "given": "Najet", "initials": "N"}, {"family": "Desai", "given": "Arpan S", "initials": "AS"}], "type": "journal article", "published": "2021-12-16", "journal": {"title": "Small", "issn": "1613-6829", "pages": "e2105832", "issn-l": null}, "abstract": "Recently, lipid nanoparticles (LNPs) have attracted attention due to their emergent use for COVID-19 mRNA vaccines. The success of LNPs can be attributed to ionizable lipids, which enable functional intracellular delivery. Previously, the authors established an automated high-throughput platform to screen ionizable lipids and identified that the LNPs generated using this automated technique show comparable or increased mRNA functional delivery in vitro as compared to LNPs prepared using traditional microfluidics techniques. In this study, the authors choose one benchmark lipid, DLin-MC3-DMA (MC3), and investigate whether the automated formulation technique can enhance mRNA functional delivery in vivo. Interestingly, a 4.5-fold improvement in mRNA functional delivery in vivo by automated LNPs as compared to LNPs formulated by conventional microfluidics techniques, is observed. Mechanistic studies reveal that particles with large size accommodate more mRNA per LNP, possess more hydrophobic surface, are more hemolytic, bind a larger protein corona, and tend to accumulate more in macropinocytosomes, which may quantitatively benefit mRNA cytosolic delivery. These data suggest that mRNA loading per particle is a critical factor that accounts for the enhanced mRNA functional delivery of automated LNPs. These mechanistic findings provide valuable insight underlying the enhanced mRNA functional delivery to accelerate future mRNA LNP product development.", "doi": "10.1002/smll.202105832", "pmid": "34914866", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:35:48.170Z", "modified": "2022-01-04T15:36:24.454Z"}, {"entity": "publication", "iuid": "54d97da6ea8f443aa5ddb6a2e05821cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54d97da6ea8f443aa5ddb6a2e05821cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54d97da6ea8f443aa5ddb6a2e05821cc"}}, "title": "An Integrated Deep Learning and Belief Rule Base Intelligent System to Predict Survival of COVID-19 Patient under Uncertainty.", "authors": [{"family": "Ahmed", "given": "Tawsin Uddin", "initials": "TU"}, {"family": "Jamil", "given": "Mohammad Newaj", "initials": "MN"}, {"family": "Hossain", "given": "Mohammad Shahadat", "initials": "MS"}, {"family": "Islam", "given": "Raihan Ul", "initials": "RU", "orcid": "0000-0002-3090-7645", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/597e3542e3fb49d881e100f33115eaf3.json"}}, {"family": "Andersson", "given": "Karl", "initials": "K"}], "type": "journal article", "published": "2021-12-16", "journal": {"title": "Cognit Comput", "issn": "1866-9956", "pages": "1-17", "issn-l": null}, "abstract": "The novel Coronavirus-induced disease COVID-19 is the biggest threat to human health at the present time, and due to the transmission ability of this virus via its conveyor, it is spreading rapidly in almost every corner of the globe. The unification of medical and IT experts is required to bring this outbreak under control. In this research, an integration of both data and knowledge-driven approaches in a single framework is proposed to assess the survival probability of a COVID-19 patient. Several neural networks pre-trained models: Xception, InceptionResNetV2, and VGG Net, are trained on X-ray images of COVID-19 patients to distinguish between critical and non-critical patients. This prediction result, along with eight other significant risk factors associated with COVID-19 patients, is analyzed with a knowledge-driven belief rule-based expert system which forms a probability of survival for that particular patient. The reliability of the proposed integrated system has been tested by using real patient data and compared with expert opinion, where the performance of the system is found promising.", "doi": "10.1007/s12559-021-09978-8", "pmid": "34931129", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "9978"}, {"db": "pmc", "key": "PMC8674031"}], "notes": [], "created": "2022-01-03T15:30:04.377Z", "modified": "2022-01-03T15:30:20.090Z"}, {"entity": "publication", "iuid": "09bb87f27350469aae706ca7d2cc2b45", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/09bb87f27350469aae706ca7d2cc2b45.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/09bb87f27350469aae706ca7d2cc2b45"}}, "title": "[Insights from creating a covid-19 biobank in Sweden].", "authors": [{"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Cornillet", "given": "Martin", "initials": "M"}, {"family": "Rooijackers", "given": "Olav", "initials": "O"}, {"family": "I Eriksson", "given": "Lars", "initials": "L"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas", "initials": "N"}], "type": "journal article", "published": "2021-12-15", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "volume": "118", "issn-l": "0023-7205"}, "abstract": "Biobanks function as important repositories for biological samples collected in health care. As such, they play an important role in enabling important medical research over time. In response to the covid-19 outbreak in Stockholm, Sweden, a group of specialists in intensive care, infectious diseases, and clinical microbiology, as well as scientists with experience in immunology and viral diseases, rapidly gathered. The group discussed how to cope with the prevailing situation, both from a clinical and a research-oriented perspective. Among strategies decided was an attempt to rapidly organize a biological sample collection organized in a biobank for immediate but also long-term research purposes. Given the pandemic conditions with a new virus, the biobank project and associated immediate immunological research tasks turned out to be challenging. In the following months, many lessons were learned from the systematic collection of clinical samples and associated immunological research. Many insights were gained of value for future pandemic preparedness.", "doi": null, "pmid": "34910294", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "21163"}], "notes": [], "created": "2021-12-18T17:49:56.486Z", "modified": "2023-01-13T13:31:26.174Z"}, {"entity": "publication", "iuid": "2a414026535b44c6829650be10fddf84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2a414026535b44c6829650be10fddf84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2a414026535b44c6829650be10fddf84"}}, "title": "Promoting a Syndemic Approach for Cardiometabolic Disease Management During COVID-19: The CAPISCO International Expert Panel.", "authors": [{"family": "Al Mahmeed", "given": "Wael", "initials": "W"}, {"family": "Al-Rasadi", "given": "Khalid", "initials": "K"}, {"family": "Banerjee", "given": "Yajnavalka", "initials": "Y"}, {"family": "Ceriello", "given": "Antonio", "initials": "A"}, {"family": "Cosentino", "given": "Francesco", "initials": "F"}, {"family": "Galia", "given": "Massimo", "initials": "M"}, {"family": "Goh", "given": "Su-Yen", "initials": "SY"}, {"family": "Kempler", "given": "Peter", "initials": "P"}, {"family": "Lessan", "given": "Nader", "initials": "N"}, {"family": "Papanas", "given": "Nikolaos", "initials": "N"}, {"family": "Rizvi", "given": "Ali A", "initials": "AA"}, {"family": "Santos", "given": "Raul D", "initials": "RD"}, {"family": "Stoian", "given": "Anca P", "initials": "AP"}, {"family": "Toth", "given": "Peter P", "initials": "PP"}, {"family": "Rizzo", "given": "Manfredi", "initials": "M"}, {"family": "CArdiometabolic Panel of International experts on Syndemic COvid-19 (CAPISCO)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-15", "journal": {"title": "Front Cardiovasc Med", "issn": "2297-055X", "volume": "8", "pages": "787761", "issn-l": null}, "abstract": "Efforts in the fight against COVID-19 are achieving success in many parts of the world, although progress remains slow in other regions. We believe that a syndemic approach needs to be adopted to address this pandemic given the strong apparent interplay between COVID-19, its related complications, and the socio-structural environment. We have assembled an international, multidisciplinary group of researchers and clinical practitioners to promote a novel syndemic approach to COVID-19: the CArdiometabolic Panel of International experts on Syndemic COvid-19 (CAPISCO). This geographically diverse group aims to facilitate collaborative-networking and scientific exchanges between researchers and clinicians facing a multitude of challenges on different continents during the pandemic. In the present article we present our \"manifesto\", with the intent to provide evidence-based guidance to the global medical and scientific community for better management of patients both during and after the current pandemic.", "doi": "10.3389/fcvm.2021.787761", "pmid": "34977193", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8715947"}], "notes": [], "created": "2022-01-04T14:44:36.587Z", "modified": "2022-01-04T14:44:36.601Z"}, {"entity": "publication", "iuid": "bfe0bc74fda7427ea3ac315a88fe927d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bfe0bc74fda7427ea3ac315a88fe927d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bfe0bc74fda7427ea3ac315a88fe927d"}}, "title": "Experiences of Online COVID-19 Information Acquisition among Persons with Type 2 Diabetes and Varying eHealth Literacy.", "authors": [{"family": "Sj\u00f6str\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Hajdarevic", "given": "Senada", "initials": "S", "orcid": "0000-0003-0661-8269", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9575f7283b80416997f0b3ef20e487b2.json"}}, {"family": "H\u00f6rnsten", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "\u00d6berg", "given": "Ulrika", "initials": "U", "orcid": "0000-0002-2803-8006", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49f675b644a844159d0154b032fec924.json"}}, {"family": "Isaksson", "given": "Ulf", "initials": "U", "orcid": "0000-0001-5191-4599", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac5e6ad1dacd498980527d25095c895f.json"}}], "type": "journal article", "published": "2021-12-15", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "24", "issn-l": null}, "abstract": "During the COVID-19 pandemic, the Internet has been a major source of information for people to keep updated with news and guidelines. However, concerns have been raised about the 'infodemic', which includes the overabundance of online information and the spread of misleading information. Adequate eHealth literacy skills among world citizens have therefore been emphasized as vital during the pandemic. Persons with type 2 diabetes have been at increased risk of severe outcomes of COVID-19 disease. This study aimed to explore online COVID-19 information acquisition experiences among persons with type 2 diabetes and varying eHealth literacy. Fifty-eight participants filled out the eHealth Literacy Scale (eHEALS), along with a qualitative questionnaire with free-text questions. Additionally, 10 participants were interviewed. Thematic analysis was applied to identify patterns in participants' experiences. Two domains were identified: perceived challenges with online information about COVID-19, and coping strategies to manage challenges. The perceived challenges were: being exposed to information overload, dealing with conflicting information, and being strongly emotionally affected. The related coping strategies were: protecting oneself, trusting authorities, taking command, and using common sense. These strategies often involved triangulation of the information obtained, including participants consulting their common sense, various sources, or family and friends. This paper highlights the crucial role of authorities in delivering online information, that according to health literacy principles, is easy to access, understand, and use. Furthermore, our results reinforce the importance of diabetes nurses, as well as healthcare professionals in general, in encouraging patients to share their Internet findings, promote information from reliable sources, and deliver tailored information that suits individual needs. Because our results underline the importance of social support in eHealth literacy and the assessment of online health information, the inclusion of family and friends needs to be increasingly considered in diabetes care. Due to the small homogenous sample, the results of this study cannot be generalized. However, the reader can assess the transferability to other situations and settings based on our contextual descriptions.", "doi": "10.3390/ijerph182413240", "pmid": "34948852", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182413240"}, {"db": "pmc", "key": "PMC8701656"}], "notes": [], "created": "2022-01-04T15:29:32.581Z", "modified": "2022-01-04T15:29:32.750Z"}, {"entity": "publication", "iuid": "ba0357094cd74fde9ff8bf38087793f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ba0357094cd74fde9ff8bf38087793f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ba0357094cd74fde9ff8bf38087793f7"}}, "title": "Dapagliflozin in patients with COVID-19: mind the kidneys - Authors' reply.", "authors": [{"family": "Kosiborod", "given": "Mikhail N", "initials": "MN"}, {"family": "Esterline", "given": "Russell", "initials": "R"}, {"family": "Oscarsson", "given": "Jan", "initials": "J"}, {"family": "Gasparyan", "given": "Samvel B", "initials": "SB"}, {"family": "Furtado", "given": "Remo H M", "initials": "RHM"}, {"family": "Verma", "given": "Subodh", "initials": "S"}, {"family": "Berwanger", "given": "Otavio", "initials": "O"}], "type": "letter", "published": "2021-12-15", "journal": {"title": "Lancet Diabetes Endocrinol", "issn": "2213-8595", "issn-l": null}, "abstract": null, "doi": "10.1016/S2213-8587(21)00326-0", "pmid": "34921753", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-8587(21)00326-0"}], "notes": [], "created": "2021-12-20T08:33:08.636Z", "modified": "2021-12-20T08:33:08.651Z"}, {"entity": "publication", "iuid": "c58762d3b71e4eaba096566c42f6a804", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c58762d3b71e4eaba096566c42f6a804.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c58762d3b71e4eaba096566c42f6a804"}}, "title": "Acute COVID-19 severity and 16-month mental morbidity trajectories in patient populations of six nations", "authors": [{"family": "Magn\u00fasd\u00f3ttir", "given": "Ingibj\u00f6rg", "initials": "I", "orcid": "0000-0002-1983-6049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/774d5ab207a74688accb27001d15e4aa.json"}}, {"family": "Lovik", "given": "Anik\u00f3", "initials": "A"}, {"family": "Unnarsd\u00f3ttir", "given": "Anna B\u00e1ra", "initials": "AB", "orcid": "0000-0002-6421-445X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2da21ebd675c4e329c47bf64bbc1578a.json"}}, {"family": "McCartney", "given": "Daniel", "initials": "D"}, {"family": "Ask", "given": "Helga", "initials": "H"}, {"family": "K\u00f5iv", "given": "Kadri", "initials": "K"}, {"family": "Nordahl Christoffersen", "given": "Lea Arregui", "initials": "LA"}, {"family": "Johnson", "given": "Sverre Urnes", "initials": "SU"}, {"family": "McIntosh", "given": "Andrew", "initials": "A", "orcid": "0000-0002-0198-4588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc50c9e995964aa5be11a155b7f95c64.json"}}, {"family": "K\u00e4hler", "given": "Anna K", "initials": "AK"}, {"family": "Campbell", "given": "Archie", "initials": "A"}, {"family": "Hauksd\u00f3ttir", "given": "Arna", "initials": "A"}, {"family": "Fawns-Ritchie", "given": "Chloe", "initials": "C"}, {"family": "Erikstrup", "given": "Christian", "initials": "C", "orcid": "0000-0001-6551-6647", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f01382b51d3e46d8b8c9d74dbed3ce81.json"}}, {"family": "Helenius", "given": "Dorte", "initials": "D"}, {"family": "Altschul", "given": "Drew", "initials": "D"}, {"family": "Thordardottir", "given": "Edda Bjork", "initials": "EB"}, {"family": "Ey\u00fe\u00f3rsson", "given": "El\u00edas", "initials": "E"}, {"family": "Frans", "given": "Emma M", "initials": "EM"}, {"family": "T\u00f3masson", "given": "Gunnar", "initials": "G"}, {"family": "J\u00f3nsd\u00f3ttir", "given": "Harpa Lind", "initials": "HL"}, {"family": "R\u00fanarsd\u00f3ttir", "given": "Harpa", "initials": "H"}, {"family": "Hjalgrim", "given": "Henrik", "initials": "H"}, {"family": "Har\u00f0ard\u00f3ttir", "given": "Hr\u00f6nn", "initials": "H"}, {"family": "Gonz\u00e1lez-Hij\u00f3n", "given": "Juan", "initials": "J"}, {"family": "Banasik", "given": "Karina", "initials": "K"}, {"family": "Dinh", "given": "Khoa Manh", "initials": "KM"}, {"family": "Lu", "given": "Li", "initials": "L"}, {"family": "Milani", "given": "Lili", "initials": "L"}, {"family": "Trogstad", "given": "Lill", "initials": "L"}, {"family": "Didriksen", "given": "Maria", "initials": "M"}, {"family": "Ebrahimi", "given": "Omid V", "initials": "OV"}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF"}, {"family": "Magnus", "given": "Per Minor", "initials": "PM"}, {"family": "Shen", "given": "Qing", "initials": "Q"}, {"family": "Nesv\u00e5g", "given": "Ragnar", "initials": "R"}, {"family": "M\u00e4gi", "given": "Reedik", "initials": "R"}, {"family": "P\u00e1lsson", "given": "Run\u00f3lfur", "initials": "R", "orcid": "0000-0001-6763-1702", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df1c1ec369a54d3ba12048edb675ab6a.json"}}, {"family": "Ostrowski", "given": "Sisse Rye", "initials": "SR"}, {"family": "Werge", "given": "Thomas", "initials": "T"}, {"family": "Hoffart", "given": "Asle", "initials": "A"}, {"family": "Porteous", "given": "David J", "initials": "DJ"}, {"family": "Fang", "given": "Fang", "initials": "F", "orcid": "0000-0002-3310-6456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b0852465cd14239a25329b976172792.json"}}, {"family": "Jakobsd\u00f3ttir", "given": "J\u00f3hanna", "initials": "J"}, {"family": "Lehto", "given": "Kelli", "initials": "K"}, {"family": "Andreassen", "given": "Ole A", "initials": "OA", "orcid": "0000-0002-4461-3568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f105232b5e5a443abbc17ac88f9b4ad6.json"}}, {"family": "Pedersen", "given": "Ole B V", "initials": "OBV"}, {"family": "Aspelund", "given": "Thor", "initials": "T", "orcid": "0000-0002-7998-5433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f3b5030190743e4b0ec0be05afb8fa8.json"}}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur Anna", "initials": "UA", "orcid": "0000-0001-5382-946X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87d1dbec7c6f4942b1db2b999eeb9ece.json"}}], "type": "posted-content", "published": "2021-12-15", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.12.13.21267368", "pmid": null, "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2023-02-13T18:39:49.120Z", "modified": "2023-02-13T18:39:49.262Z"}, {"entity": "publication", "iuid": "603e4932d45040fe8bf99638dd6c7b31", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/603e4932d45040fe8bf99638dd6c7b31.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/603e4932d45040fe8bf99638dd6c7b31"}}, "title": "The impact of the COVID-19 school closure on adolescents\u2019 use of mental healthcare services in Sweden", "authors": [{"family": "Svaleryd", "given": "Helena", "initials": "H", "orcid": "0000-0003-3072-5224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79dfce3f625e418490cac3f369f3e9e8.json"}}, {"family": "Bj\u00f6rkegren", "given": "Evelina", "initials": "E"}, {"family": "Vlachos", "given": "Jonas", "initials": "J", "orcid": "0000-0002-7717-9155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b8b751862ab4c34b580e5ace974b36c.json"}}], "type": "posted-content", "published": "2021-12-14", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.12.12.21267684", "pmid": null, "labels": {"Category: Other": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:45:44.699Z", "modified": "2022-11-22T05:43:32.647Z"}, {"entity": "publication", "iuid": "b027237f614b41f59ccd65d0b432edea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b027237f614b41f59ccd65d0b432edea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b027237f614b41f59ccd65d0b432edea"}}, "title": "Harnessing Twitter data to survey public attention and attitudes towards COVID-19 vaccines in the UK.", "authors": [{"family": "Fazel", "given": "Seena", "initials": "S"}, {"family": "Zhang", "given": "Le", "initials": "L"}, {"family": "Javid", "given": "Babak", "initials": "B"}, {"family": "Brikell", "given": "Isabell", "initials": "I"}, {"family": "Chang", "given": "Zheng", "initials": "Z"}], "type": "journal article", "published": "2021-12-14", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "23402", "issn-l": "2045-2322"}, "abstract": "Attitudes to COVID-19 vaccination vary considerably within and between countries. Although the contribution of socio-demographic factors to these attitudes has been studied, the role of social media and how it interacts with news about vaccine development and efficacy is uncertain. We examined around 2 million tweets from 522,893 persons in the UK from November 2020 to January 2021 to evaluate links between Twitter content about vaccines and major scientific news announcements about vaccines. The proportion of tweets with negative vaccine content varied, with reductions of 20-24% on the same day as major news announcement. However, the proportion of negative tweets reverted back to an average of around 40% within a few days. Engagement rates were higher for negative tweets. Public health messaging could consider the dynamics of Twitter-related traffic and the potential contribution of more targeted social media campaigns to address vaccine hesitancy.", "doi": "10.1038/s41598-021-02710-4", "pmid": "34907201", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-02710-4"}], "notes": [], "created": "2021-12-18T17:53:48.734Z", "modified": "2021-12-18T17:53:48.747Z"}, {"entity": "publication", "iuid": "0e9ffe8c65604633a45f7f253a9ee75f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e9ffe8c65604633a45f7f253a9ee75f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e9ffe8c65604633a45f7f253a9ee75f"}}, "title": "Estimating the SARS-CoV-2 infected population fraction and the infection-to-fatality ratio: a data-driven case study based on Swedish time series data.", "authors": [{"family": "Wacker", "given": "Andreas", "initials": "A"}, {"family": "J\u00f6ud", "given": "Anna", "initials": "A", "orcid": "0000-0001-7192-4911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e038a5ce2f5a47bd89e7c221651a3d24.json"}}, {"family": "Bernhardsson", "given": "Bo", "initials": "B"}, {"family": "Gerlee", "given": "Philip", "initials": "P", "orcid": "0000-0001-8503-0177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ba426c1ab741e781d2b9cd09a0b830.json"}}, {"family": "Gustafsson", "given": "Fredrik", "initials": "F"}, {"family": "Soltesz", "given": "Kristian", "initials": "K"}], "type": "journal article", "published": "2021-12-14", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "23963", "issn-l": "2045-2322"}, "abstract": "We demonstrate that finite impulse response (FIR) models can be applied to analyze the time evolution of an epidemic with its impact on deaths and healthcare strain. Using time series data for COVID-19-related cases, ICU admissions and deaths from Sweden, the FIR model gives a consistent epidemiological trajectory for a simple delta filter function. This results in a consistent scaling between the time series if appropriate time delays are applied and allows the reconstruction of cases for times before July 2020, when RT-PCR testing was not widely available. Combined with randomized RT-PCR study results, we utilize this approach to estimate the total number of infections in Sweden, and the corresponding infection-to-fatality ratio (IFR), infection-to-case ratio (ICR), and infection-to-ICU admission ratio (IIAR). Our values for IFR, ICR and IIAR are essentially constant over large parts of 2020 in contrast with claims of healthcare adaptation or mutated virus variants importantly affecting these ratios. We observe a diminished IFR in late summer 2020 as well as a strong decline during 2021, following the launch of a nation-wide vaccination program. The total number of infections during 2020 is estimated to 1.3 million, indicating that Sweden was far from herd immunity.", "doi": "10.1038/s41598-021-03269-w", "pmid": "34907208", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8671402"}, {"db": "pii", "key": "10.1038/s41598-021-03269-w"}], "notes": [], "created": "2021-12-18T17:52:24.620Z", "modified": "2023-06-19T15:31:02.834Z"}, {"entity": "publication", "iuid": "fcca4b56268f4b11ba3093964206d768", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fcca4b56268f4b11ba3093964206d768.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fcca4b56268f4b11ba3093964206d768"}}, "title": "ECG pathology and its association with death in critically ill COVID-19 patients, a cohort study.", "authors": [{"family": "Ros\u00e9n", "given": "Jacob", "initials": "J", "orcid": "0000-0001-9518-5834", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ce3d5b2cb914d72bbd476b7e1127c8d.json"}}, {"family": "Noreland", "given": "Maria", "initials": "M"}, {"family": "Stattin", "given": "Karl", "initials": "K"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Malinovschi", "given": "Andrei", "initials": "A"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Uppsala Intensive Care COVID-19 Research Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-14", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "12", "pages": "e0261315"}, "abstract": "We investigated the prevalence of ECG abnormalities and their association with mortality, organ dysfunction and cardiac biomarkers in a cohort of COVID-19 patients admitted to the intensive care unit (ICU).\r\n\r\nThis cohort study included patients with COVID-19 admitted to the ICU of a tertiary hospital in Sweden. ECG, clinical data and laboratory findings during ICU stay were extracted from medical records and ECGs obtained near ICU admission were reviewed by two independent physicians.\r\n\r\nEighty patients had an acceptable ECG near ICU-admission. In the entire cohort 30-day mortality was 28%. Compared to patients with normal ECG, among whom 30-day mortality was 16%, patients with ECG fulfilling criteria for prior myocardial infarction had higher mortality, 63%, odds ratio (OR) 9.61 (95% confidence interval (CI) 2.02-55.6) adjusted for Simplified Acute Physiology Score 3 and patients with ST-T abnormalities had 50% mortality and OR 6.05 (95% CI 1.82-21.3) in univariable analysis. Both prior myocardial infarction pattern and ST-T pathology were associated with need for vasoactive treatment and higher peak plasma levels of troponin-I, NT-pro-BNP (N-terminal pro-Brain Natriuretic Peptide), and lactate during ICU stay compared to patients with normal ECG.\r\n\r\nECG with prior myocardial infarction pattern or acute ST-T pathology at ICU admission is associated with death, need for vasoactive treatment and higher levels of biomarkers of cardiac damage and strain in severely ill COVID-19 patients, and should alert clinicians to a poor prognosis.", "doi": "10.1371/journal.pone.0261315", "pmid": "34905575", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Public Health": null, "Funder: VR": null, "Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-28860"}, {"db": "pmc", "key": "PMC8670711"}, {"db": "URL", "key": "https://doi.org/10.1371/journal.pone.0261315.s001", "description": "https://doi.org/10.1371/journal.pone.0261315.s001"}, {"db": "URL", "key": "https://doi.org/10.17044/scilifelab.14229410.v1", "description": "https://doi.org/10.17044/scilifelab.14229410.v1"}], "notes": [], "created": "2021-12-18T17:54:37.568Z", "modified": "2021-12-18T17:57:22.337Z"}, {"entity": "publication", "iuid": "144f781f894f4fa89b8d27a5bb748f5c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/144f781f894f4fa89b8d27a5bb748f5c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/144f781f894f4fa89b8d27a5bb748f5c"}}, "title": "Does Confinement Affect Treatment Dropout Rates in Patients With Gambling Disorder? A Nine-Month Observational Study.", "authors": [{"family": "Baenas", "given": "Isabel", "initials": "I"}, {"family": "Etxandi", "given": "Mikel", "initials": "M"}, {"family": "Codina", "given": "Ester", "initials": "E"}, {"family": "Granero", "given": "Roser", "initials": "R"}, {"family": "Fern\u00e1ndez-Aranda", "given": "Fernando", "initials": "F"}, {"family": "G\u00f3mez-Pe\u00f1a", "given": "M\u00f3nica", "initials": "M"}, {"family": "Moragas", "given": "Laura", "initials": "L"}, {"family": "Rivas", "given": "Sandra", "initials": "S"}, {"family": "Potenza", "given": "Marc N", "initials": "MN"}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "Del Pino-Guti\u00e9rrez", "given": "Amparo", "initials": "A"}, {"family": "Mora-Maltas", "given": "Bernat", "initials": "B"}, {"family": "Valenciano-Mendoza", "given": "Eduardo", "initials": "E"}, {"family": "Mench\u00f3n", "given": "Jos\u00e9 M", "initials": "JM"}, {"family": "Jim\u00e9nez-Murcia", "given": "Susana", "initials": "S"}], "type": "journal article", "published": "2021-12-14", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "761802", "issn-l": "1664-1078"}, "abstract": "Background and Aims: COVID-19 pandemic and confinement have represented a challenge for patients with gambling disorder (GD). Regarding treatment outcome, dropout may have been influenced by these adverse circumstances. The aims of this study were: (a) to analyze treatment dropout rates in patients with GD throughout two periods: during and after the lockdown and (b) to assess clinical features that could represent vulnerability factors for treatment dropout. Methods: The sample consisted of n=86 adults, mostly men (n=79, 91.9%) and with a mean age of 45years old (SD=16.85). Patients were diagnosed with GD according to DSM-5 criteria and were undergoing therapy at a Behavioral Addiction Unit when confinement started. Clinical data were collected through a semi-structured interview and protocolized psychometric assessment. A brief telephone survey related to COVID-19 concerns was also administered at the beginning of the lockdown. Dropout data were evaluated at two moments throughout a nine-month observational period (T1: during the lockdown, and T2: after the lockdown). Results: The risk of dropout during the complete observational period was R=32/86=0.372 (37.2%), the Incidence Density Rate (IDR) ratio T2/T1 being equal to 0.052/0.033=1.60 (p=0.252). Shorter treatment duration (p=0.007), lower anxiety (p=0.025), depressive symptoms (p=0.045) and lower use of adaptive coping strategies (p=0.046) characterized patients who abandoned treatment during the lockdown. Briefer duration of treatment (p=0.001) and higher employment concerns (p=0.044) were highlighted in the individuals who dropped out after the lockdown. Treatment duration was a predictor of dropout in both periods (p=0.005 and p<0.001, respectively). Conclusion: The present results suggest an impact of the COVID-19 pandemic on treatment dropout among patients with GD during and after the lockdown, being treatment duration a predictor of dropout. Assessing vulnerability features in GD may help clinicians identify high-risk individuals and enhance prevention and treatment approaches in future similar situations.", "doi": "10.3389/fpsyg.2021.761802", "pmid": "34970193", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8712884"}], "notes": [], "created": "2022-01-04T14:58:37.916Z", "modified": "2022-01-04T14:58:37.933Z"}, {"entity": "publication", "iuid": "7ac9e51b73514b76bbabcc91dab96516", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7ac9e51b73514b76bbabcc91dab96516.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7ac9e51b73514b76bbabcc91dab96516"}}, "title": "Comprehensive Contact Tracing, Testing and Sequencing Show Limited Transmission of SARS-CoV-2 between Children in Schools in Norway, August 2020 to May 2021.", "authors": [{"family": "Winje", "given": "Brita Askeland", "initials": "BA", "orcid": "0000-0003-2858-7248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff6f41b97fb5447cb80574cb6e671a80.json"}}, {"family": "Ofitserova", "given": "Trine Skogset", "initials": "TS"}, {"family": "Brynildsrud", "given": "Ola Br\u00f8nstad", "initials": "OB"}, {"family": "Greve-Isdahl", "given": "Margrethe", "initials": "M"}, {"family": "Bragstad", "given": "Karoline", "initials": "K"}, {"family": "Rykkvin", "given": "Rikard", "initials": "R"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "Lund", "given": "Hilde Marie", "initials": "HM"}, {"family": "Nyg\u00e5rd", "given": "Karin", "initials": "K"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}, {"family": "Brandal", "given": "Lin Thorstensen", "initials": "LT"}], "type": "journal article", "published": "2021-12-14", "journal": {"title": "Microorganisms", "issn": "2076-2607", "volume": "9", "issue": "12", "issn-l": "2076-2607"}, "abstract": "The role of children in the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in schools has been a topic of controversy. In this study among school contacts of SARS-CoV-2 positive children in 43 contact-investigations, we investigated SARS-CoV-2 transmission in Norway, August 2020-May 2021. All participants were tested twice within seven to ten days, using SARS-CoV-2 PCR on home-sampled saliva. Positive samples were whole genome sequenced. Among the 559 child contacts, eight tested positive (1.4%, 95% CI 0.62-2.80), with no significant difference between primary (1.0%, 95% CI 0.27-2.53) and secondary schools (2.6%, 95% CI 0.70-6.39), p = 0.229, nor by viral strain, non-Alpha (1.4%, 95% CI 0.50-2.94) and Alpha variant (B.1.1.7) (1.7%, 95% CI 0.21-5.99), p = 0.665. One adult contact (1/100) tested positive. In 34 index cases, we detected 13 different SARS-CoV-2 Pango lineage variants, with B.1.1.7 being most frequent. In the eight contact-investigations with SARS-CoV-2 positive contacts, four had the same sequence identity as the index, one had no relation, and three were inconclusive. With mitigation measures in place, the spread of SARS-CoV-2 from children in schools is limited. By excluding contact-investigations with adult cases known at the time of enrolment, our data provide a valid estimate on the role of children in the transmission of SARS-CoV-2 in schools.", "doi": "10.3390/microorganisms9122587", "pmid": "34946187", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "microorganisms9122587"}, {"db": "pmc", "key": "PMC8705768"}], "notes": [], "created": "2022-01-04T15:31:42.547Z", "modified": "2022-01-04T15:31:42.605Z"}, {"entity": "publication", "iuid": "8f1e7fb4b8374e2eb1cda889dcc4a2b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f1e7fb4b8374e2eb1cda889dcc4a2b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f1e7fb4b8374e2eb1cda889dcc4a2b2"}}, "title": "Broad anti-SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1/mRNA-1273 prime-boost vaccination", "authors": [{"family": "Kaku", "given": "Chengzi I", "initials": "CI", "orcid": "0000-0002-9854-8351", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be56dead52324203a9b37fc32f23626f.json"}}, {"family": "Champney", "given": "Elizabeth R", "initials": "ER"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Johnson", "given": "Carl E", "initials": "CE"}, {"family": "Ahlm", "given": "Clas", "initials": "C", "orcid": "0000-0003-2018-8592", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/833d0293b5d74bbabec63e922cd19d54.json"}}, {"family": "Sakharkar", "given": "Mrunal", "initials": "M", "orcid": "0000-0002-2717-5201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2694a69ce874c3f93cf4f9ed8d736dd.json"}}, {"family": "Ackerman", "given": "Margaret E", "initials": "ME", "orcid": "0000-0002-4253-3476", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10fea712c93441dd922bbcb531b46148.json"}}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE", "orcid": "0000-0001-6904-742X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e41c0e1c9c7b499fb3d844d4c572e7bb.json"}}, {"family": "Walker", "given": "Laura M", "initials": "LM", "orcid": "0000-0001-7704-3197", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a40fc6cfefc14436a12cc467c3cacd54.json"}}], "type": "posted-content", "published": "2021-12-14", "journal": {"title": "MedRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.12.13.21267598", "pmid": null, "labels": {"Type: Preprint": null, "Category: Vaccines": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Research Area: Vaccine": null, "Funder: VR": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:46:15.910Z", "modified": "2022-02-14T14:55:09.518Z"}, {"entity": "publication", "iuid": "9633f53476a44e038f64329f6684a8ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9633f53476a44e038f64329f6684a8ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9633f53476a44e038f64329f6684a8ee"}}, "title": "Biomarkers Predict In-Hospital Major Adverse Cardiac Events in COVID-19 Patients: A Multicenter International Study.", "authors": [{"family": "Henein", "given": "Michael Y", "initials": "MY", "orcid": "0000-0002-6089-5614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe79bb10eb4348948599443b7b396faf.json"}}, {"family": "Mandoli", "given": "Giulia Elena", "initials": "GE", "orcid": "0000-0002-3184-3006", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc927b7843b44bdd87232563c7faff19.json"}}, {"family": "Pastore", "given": "Maria Concetta", "initials": "MC", "orcid": "0000-0002-7223-141X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/55e79d1bf0294864ae1cdb57aa4a4844.json"}}, {"family": "Ghionzoli", "given": "Nicol\u00f2", "initials": "N"}, {"family": "Hasson", "given": "Fouhad", "initials": "F"}, {"family": "Nisar", "given": "Muhammad K", "initials": "MK", "orcid": "0000-0002-5132-3972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/57bb7f7ab7c04904a4c0032679c32880.json"}}, {"family": "Islam", "given": "Mohammed", "initials": "M"}, {"family": "Bandera", "given": "Francesco", "initials": "F"}, {"family": "Marrocco-Trischitta", "given": "Massimiliano M", "initials": "MM"}, {"family": "Baroni", "given": "Irene", "initials": "I"}, {"family": "Malagoli", "given": "Alessandro", "initials": "A", "orcid": "0000-0001-9119-4311", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3808163253445a0923454d2df22ad30.json"}}, {"family": "Rossi", "given": "Luca", "initials": "L"}, {"family": "Biagi", "given": "Andrea", "initials": "A"}, {"family": "Citro", "given": "Rodolfo", "initials": "R"}, {"family": "Ciccarelli", "given": "Michele", "initials": "M", "orcid": "0000-0003-2379-1960", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d76634bdc8024f53ba78a6e72ab3d041.json"}}, {"family": "Silverio", "given": "Angelo", "initials": "A", "orcid": "0000-0001-9749-8092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/610b8ded802247ceb13def87bcc5a1d7.json"}}, {"family": "Biagioni", "given": "Giulia", "initials": "G"}, {"family": "Moutiris", "given": "Joseph A", "initials": "JA"}, {"family": "Vancheri", "given": "Federico", "initials": "F", "orcid": "0000-0002-5268-063X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c112118f1d94c1a95466127919064e4.json"}}, {"family": "Mazzola", "given": "Giovanni", "initials": "G"}, {"family": "Geraci", "given": "Giulio", "initials": "G"}, {"family": "Thomas", "given": "Liza", "initials": "L"}, {"family": "Altman", "given": "Mikhail", "initials": "M"}, {"family": "Pernow", "given": "John", "initials": "J"}, {"family": "Ahmed", "given": "Mona", "initials": "M", "orcid": "0000-0002-9579-1380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4164b11cface4f849c5e08bf41c8c5d9.json"}}, {"family": "Santoro", "given": "Ciro", "initials": "C", "orcid": "0000-0002-6329-1680", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2e9af60986147238aff6cd0dd5e9600.json"}}, {"family": "Esposito", "given": "Roberta", "initials": "R"}, {"family": "Casas", "given": "Guillem", "initials": "G", "orcid": "0000-0001-7122-320X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f0ed65a87cc40a28c45996b0510981a.json"}}, {"family": "Fern\u00e1ndez-Galera", "given": "Rub\u00e9n", "initials": "R"}, {"family": "Gonzalez", "given": "Maribel", "initials": "M"}, {"family": "Rodriguez Palomares", "given": "Jose", "initials": "J"}, {"family": "Byty\u00e7i", "given": "Ibadete", "initials": "I", "orcid": "0000-0002-8996-4257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba2f218876104573a8e529b1c2b6f671.json"}}, {"family": "Dini", "given": "Frank Lloyd", "initials": "FL", "orcid": "0000-0003-1458-4820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/548dbd176bf0475b8c70c8942610312b.json"}}, {"family": "Cameli", "given": "Paolo", "initials": "P", "orcid": "0000-0001-8639-2882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30defb513b86480dbeb48f1b75c95327.json"}}, {"family": "Franchi", "given": "Federico", "initials": "F"}, {"family": "Bajraktari", "given": "Gani", "initials": "G", "orcid": "0000-0003-0410-968X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a2b0b473f4e471fb3443c28bf9002b9.json"}}, {"family": "Badano", "given": "Luigi Paolo", "initials": "LP"}, {"family": "Cameli", "given": "Matteo", "initials": "M", "orcid": "0000-0003-3872-8964", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e64899d051a84cd8a0cac5f503e03251.json"}}], "type": "journal article", "published": "2021-12-14", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "10", "issue": "24", "issn-l": "2077-0383"}, "abstract": "The COVID-19 pandemic carries a high burden of morbidity and mortality worldwide. We aimed to identify possible predictors of in-hospital major cardiovascular (CV) events in COVID-19.\n\nWe retrospectively included patients hospitalized for COVID-19 from 10 centers. Clinical, biochemical, electrocardiographic, and imaging data at admission and medications were collected. Primary endpoint was a composite of in-hospital CV death, acute heart failure (AHF), acute myocarditis, arrhythmias, acute coronary syndromes (ACS), cardiocirculatory arrest, and pulmonary embolism (PE).\n\nOf the 748 patients included, 141(19%) reached the set endpoint: 49 (7%) CV death, 15 (2%) acute myocarditis, 32 (4%) sustained-supraventricular or ventricular arrhythmias, 14 (2%) cardiocirculatory arrest, 8 (1%) ACS, 41 (5%) AHF, and 39 (5%) PE. Patients with CV events had higher age, body temperature, creatinine, high-sensitivity troponin, white blood cells, and platelet counts at admission and were more likely to have systemic hypertension, renal failure (creatinine \u2265 1.25 mg/dL), chronic obstructive pulmonary disease, atrial fibrillation, and cardiomyopathy. On univariate and multivariate analysis, troponin and renal failure were associated with the composite endpoint. Kaplan-Meier analysis showed a clear divergence of in-hospital composite event-free survival stratified according to median troponin value and the presence of renal failure (Log rank p < 0.001).\n\nOur findings, derived from a multicenter data collection study, suggest the routine use of biomarkers, such as cardiac troponin and serum creatinine, for in-hospital prediction of CV events in patients with COVID-19.", "doi": "10.3390/jcm10245863", "pmid": "34945166", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "jcm10245863"}, {"db": "pmc", "key": "PMC8703972"}], "notes": [], "created": "2022-01-04T15:32:03.472Z", "modified": "2022-01-04T15:32:03.918Z"}, {"entity": "publication", "iuid": "19cbe373455c4122b9b149c0f0f6afa6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19cbe373455c4122b9b149c0f0f6afa6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19cbe373455c4122b9b149c0f0f6afa6"}}, "title": "Sleep and daytime problems during the COVID-19 pandemic and effects of coronavirus infection, confinement and financial suffering: a multinational survey using a harmonised questionnaire.", "authors": [{"family": "Partinen", "given": "Markku", "initials": "M", "orcid": "0000-0002-8182-9368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7920bcc4716848f7bd1cb89c8bdd0d5a.json"}}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "Espie", "given": "Colin", "initials": "C"}, {"family": "Chung", "given": "Frances", "initials": "F", "orcid": "0000-0001-9576-3606", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed55f48b6d8e400b8fd2c591a738260a.json"}}, {"family": "Penzel", "given": "Thomas", "initials": "T", "orcid": "0000-0002-4304-0112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0dc4e472c71460ab792f74bc8163a9a.json"}}, {"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Bolstad", "given": "Courtney J", "initials": "CJ"}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J"}, {"family": "Chan", "given": "Rachel Ngan Yin", "initials": "RNY"}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L"}, {"family": "Han", "given": "Fang", "initials": "F"}, {"family": "Inoue", "given": "Yuichi", "initials": "Y"}, {"family": "Matsui", "given": "Kentaro", "initials": "K"}, {"family": "Leger", "given": "Damien", "initials": "D"}, {"family": "Cunha", "given": "Ana Suely", "initials": "AS"}, {"family": "Merikanto", "given": "Ilona", "initials": "I"}, {"family": "Mota-Rolim", "given": "Sergio", "initials": "S"}, {"family": "Nadorff", "given": "Michael", "initials": "M"}, {"family": "Plazzi", "given": "Giuseppe", "initials": "G"}, {"family": "Schneider", "given": "Jules", "initials": "J"}, {"family": "Sieminski", "given": "Mariusz", "initials": "M"}, {"family": "Wing", "given": "Yun-Kwok", "initials": "Y"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B", "orcid": "0000-0001-7051-745X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b72d97a35fa4590b5d05f0fd3524f2e.json"}}], "type": "journal article", "published": "2021-12-13", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "12", "pages": "e050672"}, "abstract": "Sleep is important for human health and well-being. No previous study has assessed whether the COVID-19 pandemic impacts sleep and daytime function across the globe.\r\n\r\nThis large-scale international survey used a harmonised questionnaire. Fourteen countries participated during the period of May-August 2020. Sleep and daytime problems (poor sleep quality, sleep onset and maintenance problems, nightmares, hypnotic use, fatigue and excessive sleepiness) occurring 'before' and 'during' the pandemic were investigated. In total, 25 484 people participated and 22 151 (86.9%) responded to the key parameters and were included. Effects of COVID-19, confinement and financial suffering were considered. In the fully adjusted logistic regression models, results (weighted and stratified by country) were adjusted for gender, age, marital status, educational level, ethnicity, presence of sleep problems before COVID-19 and severity of the COVID-19 pandemic in each country at the time of the survey.\r\n\r\nThe responders were mostly women (64%) with a mean age 41.8 (SD 15.9) years (median 39, range 18-95). Altogether, 3.0% reported having had COVID-19; 42.2% reported having been in confinement; and 55.9% had suffered financially. All sleep and daytime problems worsened during the pandemic by about 10% or more. Also, some participants reported improvements in sleep and daytime function. For example, sleep quality worsened in about 20% of subjects and improved in about 5%. COVID-19 was particularly associated with poor sleep quality, early morning awakening and daytime sleepiness. Confinement was associated with poor sleep quality, problems falling asleep and decreased use of hypnotics. Financial suffering was associated with all sleep and daytime problems, including nightmares and fatigue, even in the fully adjusted logistic regression models.\r\n\r\nSleep problems, fatigue and excessive sleepiness increased significantly worldwide during the first phase of the COVID-19 pandemic. Problems were associated with confinement and especially with financial suffering.", "doi": "10.1136/bmjopen-2021-050672", "pmid": "34903540", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-050672"}, {"db": "pmc", "key": "PMC8671846"}], "notes": [], "created": "2021-12-18T17:58:46.977Z", "modified": "2022-11-22T05:44:08.358Z"}, {"entity": "publication", "iuid": "6276d42a70524ee0bbfd239bccd5247a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6276d42a70524ee0bbfd239bccd5247a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6276d42a70524ee0bbfd239bccd5247a"}}, "title": "Pre-pandemic psychological and behavioral predictors of responses to the COVID-19 pandemic in nine countries.", "authors": [{"family": "Lansford", "given": "Jennifer E", "initials": "JE", "orcid": "0000-0003-1956-4917", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/099f957450e743acab538878cc487a27.json"}}, {"family": "Skinner", "given": "Ann T", "initials": "AT"}, {"family": "Godwin", "given": "Jennifer", "initials": "J"}, {"family": "Chang", "given": "Lei", "initials": "L"}, {"family": "Deater-Deckard", "given": "Kirby", "initials": "K"}, {"family": "Di Giunta", "given": "Laura", "initials": "L"}, {"family": "Dodge", "given": "Kenneth A", "initials": "KA"}, {"family": "Gurdal", "given": "Sevtap", "initials": "S"}, {"family": "Liu", "given": "Qin", "initials": "Q"}, {"family": "Long", "given": "Qian", "initials": "Q"}, {"family": "Oburu", "given": "Paul", "initials": "P"}, {"family": "Pastorelli", "given": "Concetta", "initials": "C"}, {"family": "Sorbring", "given": "Emma", "initials": "E"}, {"family": "Steinberg", "given": "Laurence", "initials": "L"}, {"family": "Tapanya", "given": "Sombat", "initials": "S"}, {"family": "Uribe Tirado", "given": "Liliana Maria", "initials": "LM"}, {"family": "Yotanyamaneewong", "given": "Saengduean", "initials": "S"}, {"family": "Alampay", "given": "Liane Pe\u00f1a", "initials": "LP"}, {"family": "Al-Hassan", "given": "Suha M", "initials": "SM"}, {"family": "Bacchini", "given": "Dario", "initials": "D"}, {"family": "Bornstein", "given": "Marc H", "initials": "MH"}], "type": "journal article", "published": "2021-12-13", "journal": {"title": "Dev Psychopathol", "issn": "1469-2198", "pages": "1-16", "issn-l": null}, "abstract": "Prior to the COVID-19 pandemic, adolescents (N = 1,330; Mages = 15 and 16; 50% female), mothers, and fathers from nine countries (China, Colombia, Italy, Jordan, Kenya, Philippines, Sweden, Thailand, United States) reported on adolescents' internalizing and externalizing problems, adolescents completed a lab-based task to assess tendency for risk-taking, and adolescents reported on their well-being. During the pandemic, participants (Mage = 20) reported on changes in their internalizing, externalizing, and substance use compared to before the pandemic. Across countries, adolescents' internalizing problems pre-pandemic predicted increased internalizing during the pandemic, and poorer well-being pre-pandemic predicted increased externalizing and substance use during the pandemic. Other relations varied across countries, and some were moderated by confidence in the government's handling of the pandemic, gender, and parents' education.", "doi": "10.1017/S0954579421001139", "pmid": "34895387", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0954579421001139"}], "notes": [], "created": "2021-12-18T18:03:30.717Z", "modified": "2021-12-18T18:03:30.766Z"}, {"entity": "publication", "iuid": "0e063f882a674f9f8044b640a8967486", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e063f882a674f9f8044b640a8967486.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e063f882a674f9f8044b640a8967486"}}, "title": "Omicron SARS-CoV-2 variant: Unique features and their impact on pre-existing antibodies.", "authors": [{"family": "Kannan", "given": "Saathvik R", "initials": "SR"}, {"family": "Spratt", "given": "Austin N", "initials": "AN"}, {"family": "Sharma", "given": "Kalicharan", "initials": "K"}, {"family": "Chand", "given": "Hitendra S", "initials": "HS"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}, {"family": "Singh", "given": "Kamal", "initials": "K"}], "type": "journal article", "published": "2021-12-13", "journal": {"title": "J Autoimmun", "issn": "1095-9157", "issn-l": null, "volume": "126", "issue": null, "pages": "102779"}, "abstract": "Severe Acute Respiratory Coronavirus (SARS-CoV-2) has been emerging in the form of different variants since its first emergence in early December 2019. A new Variant of Concern (VOC) named the Omicron variant (B.1.1.529) was reported recently. This variant has a large number of mutations in the S protein. To date, there exists a limited information on the Omicron variant. Here we present the analyses of mutation distribution, the evolutionary relationship of Omicron with previous variants, and probable structural impact of mutations on antibody binding. Our analyses show the presence of 46 high prevalence mutations specific to Omicron. Twenty-three of these are localized within the spike (S) protein and the rest localized to the other 3 structural proteins of the virus, the envelope (E), membrane (M), and nucleocapsid (N). Phylogenetic analysis showed that the Omicron is closely related to the Gamma (P.1) variant. The structural analyses showed that several mutations are localized to the region of the S protein that is the major target of antibodies, suggesting that the mutations in the Omicron variant may affect the binding affinities of antibodies to the S protein.", "doi": "10.1016/j.jaut.2021.102779", "pmid": "34915422", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Category: Omicron VoC": null}, "xrefs": [{"db": "pii", "key": "S0896-8411(21)00187-6"}], "notes": [], "created": "2021-12-18T17:45:00.563Z", "modified": "2022-01-12T20:58:21.050Z"}, {"entity": "publication", "iuid": "0aa5c8f8220e471593a756d4bc1b6241", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0aa5c8f8220e471593a756d4bc1b6241.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0aa5c8f8220e471593a756d4bc1b6241"}}, "title": "Emergence, evolution, and vaccine production approaches of SARS-CoV-2 virus: benefits of getting vaccinated and common questions.", "authors": [{"family": "Hassanin", "given": "Abdallah A", "initials": "AA"}, {"family": "Haidar Abbas Raza", "given": "Sayed", "initials": "S"}, {"family": "Ahmed Ujjan", "given": "Javed", "initials": "J"}, {"family": "Aysh ALrashidi", "given": "Ayshah", "initials": "A"}, {"family": "Sitohy", "given": "Basel M", "initials": "BM"}, {"family": "Al-Surhanee", "given": "Ameena A", "initials": "AA"}, {"family": "Saad", "given": "Ahmed M", "initials": "AM"}, {"family": "Mohamed Al-Hazani", "given": "Tahani", "initials": "T"}, {"family": "Osman Atallah", "given": "Osama", "initials": "O"}, {"family": "Al Syaad", "given": "Khalid M", "initials": "KM"}, {"family": "Ezzat Ahmed", "given": "Ahmed", "initials": "A"}, {"family": "Swelum", "given": "Ayman A", "initials": "AA"}, {"family": "El-Saadony", "given": "Mohamed T", "initials": "MT"}, {"family": "Sitohy", "given": "Mahmoud Z", "initials": "MZ"}], "type": "journal article", "published": "2021-12-13", "journal": {"title": "Saudi J Biol Sci", "issn": "1319-562X", "issn-l": null}, "abstract": "The emergence of coronavirus disease 2019 (COVID-19) pandemic in Wuhan city, China at the end of 2019 made it urgent to identify the origin of the causal pathogen and its molecular evolution, to appropriately design an effective vaccine. This study analyzes the evolutionary background of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or SARS-2) in accordance with its close relative SARS-CoV (SARS-1), which was emerged in 2002. A comparative genomic and proteomic study was conducted on SARS-2, SARS-1, and Middle East respiratory syndrome coronavirus (MERS), which was emerged in 2012. In silico analysis inferred the genetic variability among the tested viruses. The SARS-1 genome harbored 11 genes encoding 12 proteins, while SARS-2 genome contained only 10 genes encoding for 10 proteins. MERS genome contained 11 genes encoding 11 proteins. The analysis also revealed a slight variation in the whole genome size of SARS-2 comparing to its siblings resulting from sequential insertions and deletions (indels) throughout the viral genome particularly ORF1AB, spike, ORF10 and ORF8. The effective indels were observed in the gene encoding the spike protein that is responsible for viral attachment to the angiotensin-converting enzyme 2 (ACE2) cell receptor and initiating infection. These indels are responsible for the newly emerging COVID-19 variants \u03b1CoV, \u03b2CoV, \u03b3CoV and \u03b4CoV. Nowadays, few effective COVID-19 vaccines developed based on spike (S) glycoprotein were approved and become available worldwide. Currently available vaccines can relatively prevent the spread of COVID-19 and suppress the disease. The traditional (killed or attenuated virus vaccine and antibody-based vaccine) and innovated vaccine production technologies (RNA- and DNA-based vaccines and viral vectors) are summarized in this review. We finally highlight the most common questions related to COVID-19 disease and the benefits of getting vaccinated.", "doi": "10.1016/j.sjbs.2021.12.020", "pmid": "34924802", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1319-562X(21)01053-6"}, {"db": "pmc", "key": "PMC8667566"}], "notes": [], "created": "2022-01-03T15:21:37.660Z", "modified": "2022-01-03T15:21:51.284Z"}, {"entity": "publication", "iuid": "92a3a47c712744c8956a96910197caf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/92a3a47c712744c8956a96910197caf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/92a3a47c712744c8956a96910197caf3"}}, "title": "Clinical presentation and disease course in patients with flu-like illness: does microbiological aetiology matter?", "authors": [{"family": "Verheij", "given": "Theo", "initials": "T"}, {"family": "Cianci", "given": "Daniela", "initials": "D"}, {"family": "van der Velden", "given": "Alike", "initials": "A"}, {"family": "Butler", "given": "Christopher C", "initials": "CC"}, {"family": "Bongard", "given": "Emily", "initials": "E"}, {"family": "Coenen", "given": "Samuel", "initials": "S"}, {"family": "Colliers", "given": "Annelies", "initials": "A"}, {"family": "Francis", "given": "Nick", "initials": "N"}, {"family": "Little", "given": "Paul", "initials": "P"}, {"family": "Godycki-Cwirko", "given": "Maciek", "initials": "M"}, {"family": "Llor", "given": "Carl", "initials": "C"}, {"family": "Chlabicz", "given": "Slawomir", "initials": "S"}, {"family": "Lionis", "given": "Christos", "initials": "C"}, {"family": "Sundvall", "given": "P\u00e4r-Daniel", "initials": "PD"}, {"family": "Bjerrum", "given": "Lars", "initials": "L"}, {"family": "De Sutter", "given": "An", "initials": "A"}, {"family": "Aabenhus", "given": "Rune", "initials": "R"}, {"family": "Jonassen Harbin", "given": "Nicolay", "initials": "N"}, {"family": "Lindbaek", "given": "Morten", "initials": "M"}, {"family": "Glinz", "given": "Dominik", "initials": "D"}, {"family": "Bucher", "given": "Heiner", "initials": "H"}, {"family": "Kovacs", "given": "Bernadett", "initials": "B"}, {"family": "Seifert", "given": "Bohumil", "initials": "B"}, {"family": "Touboul Lundgren", "given": "Pia", "initials": "P"}, {"family": "de Paor", "given": "Muireann", "initials": "M"}, {"family": "Radzeviciene JUrgute", "given": "Ruta", "initials": "R"}, {"family": "Matheeussen", "given": "Veerle", "initials": "V"}, {"family": "Goossens", "given": "Herman", "initials": "H"}, {"family": "Ieven", "given": "Margareta", "initials": "M"}], "type": "journal article", "published": "2021-12-13", "journal": {"title": "Br J Gen Pract", "issn": "1478-5242", "issn-l": null}, "abstract": "There is little evidence about the relation between aetiology, illness severity and clinical course of respiratory tract infections (RTI) in primary care. Understanding these associations would aid to develop effective management strategies for these infections.\n\nTo investigate whether the clinical presentation and illness course differ between RTI in whom a viral pathogen was detected and those in whom a potential bacterial pathogen was found.\n\nPost hoc analysis of data from a pragmatic randomised trial on the effects of oseltamivir in patients with influenza-like illness (ILI) in primary care (n=3266) in 15 European countries.\n\nPatient characteristics, signs and symptoms were registered at baseline. Naso-pharyngeal (adults) or nasal and pharyngeal (children) swabs were taken for PCR analysis. Patients were followed up until 28 days after inclusion. Regression models and Kaplan-Meier curves were used to analyse the relation between aetiology, clinical presentation at baseline and course of disease including complications.\n\nExcept for a less prominent congested nose (OR 0.55, CI 0.35 - 0.86) and acute cough (OR 0.52, CI 0.27 - 0.65) in ILI patients in whom a possible bacterial pathogen was isolated, there were no clear clinical differences in presentations between those with a possible bacterial aetiology than in those with a viral one. Also the course of disease and complications were not related to aetiology.\n\nGiven the currently available microbiological tests and antimicrobial treatments, and outside pandemics like COVID-19, microbiological testing in primary care patients with ILI seems to have limited value.", "doi": "10.3399/BJGP.2021.0344", "pmid": "34990385", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "BJGP.2021.0344"}], "notes": [], "created": "2022-01-10T15:32:25.010Z", "modified": "2022-01-10T15:33:16.872Z"}, {"entity": "publication", "iuid": "8a4515a6f1e84870b7936c53b3260746", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a4515a6f1e84870b7936c53b3260746.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a4515a6f1e84870b7936c53b3260746"}}, "title": "COVID-19 pandemic and the great impulse to telemedicine: the basis of the WONCA Europe Statement on Telemedicine at the WHO Europe 70th Regional Meeting September 2020.", "authors": [{"family": "Petrazzuoli", "given": "Ferdinando", "initials": "F", "orcid": "0000-0003-1058-492X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50bb7fdd235f46629be48fdff0a5fd6c.json"}}, {"family": "Kurpas", "given": "Donata", "initials": "D"}, {"family": "Vinker", "given": "Shlomo", "initials": "S"}, {"family": "Sarkisova", "given": "Valentina", "initials": "V"}, {"family": "Eleftheriou", "given": "Androulla", "initials": "A"}, {"family": "\u017bakowicz", "given": "Anna", "initials": "A", "orcid": "0000-0001-9658-8918", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/047c309284f143e8a5fd0e1103a53a1b.json"}}, {"family": "Aarendonk", "given": "Diederik", "initials": "D", "orcid": "0000-0002-8973-5446", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f2df4a7937fa4833a73389b2a420a730.json"}}, {"family": "Ungan", "given": "Mehmet", "initials": "M", "orcid": "0000-0002-6078-2177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5017979702474b50820ef5d65bb10433.json"}}], "type": "journal article", "published": "2021-12-13", "journal": {"title": "Prim Health Care Res Dev", "issn": "1477-1128", "volume": "22", "pages": "e80", "issn-l": null}, "abstract": "Telemedicine is the use of telecommunication and information technologies to support the delivery of healthcare at a distance, guaranteeing patients healthcare by facilitating access where barriers exist; the COVID-19 pandemic has attracted worldwide interest in this field.The purpose of this paper is to highlight the main pros and cons of telemedicine, which serve as the basis of the WONCA Europe Statement at the WHO Europe 70th Regional Meeting on 14 September 2020.Pros of telemedicine include virtual healthcare at home, where patients receive support in certain conditions without leaving their houses. During a pandemic, it can be adopted to limit physical human interaction. Unfortunately, it can negatively affect the quality of the doctor-patient relationship, the quality of the physical examination, and the quality of care. Telemedicine requires effective infrastructure and robust investments to be feasible and effective.", "doi": "10.1017/S1463423621000633", "pmid": "34895388", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1463423621000633"}], "notes": [], "created": "2021-12-18T18:03:07.295Z", "modified": "2021-12-18T18:03:07.462Z"}, {"entity": "publication", "iuid": "15e8d389e07a4f74905c650a0fbe6b30", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15e8d389e07a4f74905c650a0fbe6b30.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15e8d389e07a4f74905c650a0fbe6b30"}}, "title": "Mental health indicators in Sweden over a 12-month period during the COVID-19 pandemic", "authors": [{"family": "Lovik", "given": "Anik\u00f3", "initials": "A", "orcid": "0000-0002-6397-5011", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e50d5a79a1234cd79b22ec2eebf6f410.json"}}, {"family": "Gonz\u00e1lez-Hij\u00f3n", "given": "Juan", "initials": "J", "orcid": "0000-0002-3354-6697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/035df95b22194d599ab916c363018cb0.json"}}, {"family": "K\u00e4hler", "given": "Anna K", "initials": "AK", "orcid": "0000-0003-4047-4588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6d52ec01645417eb73e2bfe6c3106bd.json"}}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA", "orcid": "0000-0001-5382-946X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87d1dbec7c6f4942b1db2b999eeb9ece.json"}}, {"family": "Frans", "given": "Emma M", "initials": "EM", "orcid": "0000-0002-9791-687X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/157f412416124221ab8387bfaee3b75b.json"}}, {"family": "Magnusson", "given": "Patrik K E", "initials": "PKE"}, {"family": "Pedersen", "given": "Nancy L", "initials": "NL", "orcid": "0000-0001-8057-3543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d52d7b52d5d44febc084912148555d2.json"}}, {"family": "Hall", "given": "Per", "initials": "P", "orcid": "0000-0002-5640-9126", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36cad09fa55242b38353f6cc9081e65d.json"}}, {"family": "Czene", "given": "Kamila", "initials": "K", "orcid": "0000-0002-3233-5695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43c2cbe995a64134bc53e1c57800d798.json"}}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF", "orcid": "0000-0002-6619-873X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f9632d685f348cea7a69ebfe51ad0ab.json"}}, {"family": "Fang", "given": "Fang", "initials": "F", "orcid": "0000-0002-3310-6456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b0852465cd14239a25329b976172792.json"}}], "type": "posted-content", "published": "2021-12-11", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.12.10.21267338", "pmid": null, "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Preprint": null, "Funder: NordForsk": null}, "xrefs": [], "notes": [], "created": "2023-02-13T18:39:39.428Z", "modified": "2023-10-04T08:18:19.334Z"}, {"entity": "publication", "iuid": "6b238744a79b413380ea8cb666d8ea3e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b238744a79b413380ea8cb666d8ea3e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b238744a79b413380ea8cb666d8ea3e"}}, "title": "Immunogenicity after six months of BNT162b2 vaccination in frail or disabled nursing home residents: the COVID\u2010A Study", "authors": [{"family": "R\u00edos", "given": "Sergio Salmer\u00f3n", "initials": "SS"}, {"family": "Zamora", "given": "Elisa Bel\u00e9n Cort\u00e9s", "initials": "EBC"}, {"family": "C\u00e9spedes", "given": "Almudena Avenda\u00f1o", "initials": "AA"}, {"family": "Rizos", "given": "Luis Romero", "initials": "LR"}, {"family": "S\u00e1nchez\u2010Jurado", "given": "Pedro Manuel", "initials": "PM"}, {"family": "S\u00e1nchez\u2010Nievas", "given": "Gin\u00e9s", "initials": "G"}, {"family": "Romero", "given": "Marta Mas", "initials": "MM"}, {"family": "Tabernero Sahuquillo", "given": "Mar\u00eda Teresa", "initials": "MT"}, {"family": "Se\u00f1alada", "given": "Jos\u00e9 Joaqu\u00edn Blas", "initials": "JJB"}, {"family": "Romero", "given": "Antonio Murillo", "initials": "AM"}, {"family": "Nogueras", "given": "Inmaculada Garc\u00eda", "initials": "IG"}, {"family": "Dios Estrella Cazalla", "given": "Juan", "initials": "J"}, {"family": "Andr\u00e9s\u2010Pretel", "given": "Fernando", "initials": "F"}, {"family": "Lauschke", "given": "Volker Martin", "initials": "VM"}, {"family": "Stebbing", "given": "Justin", "initials": "J"}, {"family": "Abizanda", "given": "Pedro", "initials": "P", "orcid": "0000-0002-4707-2963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed9e8a3fed5842cd9ad7d5653b85c4a1.json"}}], "type": "journal-article", "published": "2021-12-11", "journal": {"title": "J Am Geriatr Soc", "issn": "0002-8614", "issn-l": null}, "abstract": null, "doi": "10.1111/jgs.17620", "pmid": null, "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:45:43.140Z", "modified": "2021-12-12T06:45:43.166Z"}, {"entity": "publication", "iuid": "ce55eff25b8f4e148e130386faafb114", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ce55eff25b8f4e148e130386faafb114.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ce55eff25b8f4e148e130386faafb114"}}, "title": "The profile of the COvid-19 VACcination register SAFEty study in Sweden (CoVacSafe-SE).", "authors": [{"family": "Ljung", "given": "Rickard", "initials": "R"}, {"family": "Sundstr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Gr\u00fcnewald", "given": "Maria", "initials": "M"}, {"family": "Backman", "given": "Charlotte", "initials": "C"}, {"family": "Feltelius", "given": "Nils", "initials": "N"}, {"family": "Gedeborg", "given": "Rolf", "initials": "R"}, {"family": "Zethelius", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2021-12-10", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "volume": "126", "issn-l": "0300-9734"}, "abstract": "The coronavirus disease 2019 (COVID-19) vaccines have been rapidly implemented in national vaccination programs world-wide after accelerated approval processes. The large population exposure achieved in very short time requires systematic monitoring of safety. The Swedish Medical Products Agency has launched a project platform for epidemiological surveillance to detect and characterise suspected adverse effects of COVID-19 vaccines in Sweden.\n\nThe platform includes all individuals 12 years or older in Sweden in 2021 and will be updated annually. Data, including vaccine and COVID-19 disease data, socioeconomic and demographic data, comorbidity, prescribed medicines and healthcare utilisation outcomes, are obtained from several national registers in collaboration with other Swedish Government agencies. Data from 2015 to 2019 are used as a historical comparison cohort unexposed to both the COVID-19 pandemic and to the COVID-19 vaccines.\n\nThe primary study cohort includes 8,305,978 adults 18 years and older permanently residing in Sweden on 31 December 2020. The historical control cohort includes 8,679,641 subjects. By 31 July 2021, around 50% of those 18 years and older and two-thirds of those 50 years and older were vaccinated with at least one dose, 90% of those 70 years or older had two doses.\n\nThe nationwide register-based study cohort created by the Swedish Medical Products Agency with regular updates of individual level linkage of COVID-19 vaccination exposure data to other health data registers will facilitate both safety signal detection and evaluation and other pharmacoepidemiological studies.", "doi": "10.48101/ujms.v126.8136", "pmid": "34984096", "labels": {"Category: Vaccines": null, "Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC8693580"}, {"db": "pii", "key": "8136"}], "notes": [], "created": "2022-01-10T15:34:26.263Z", "modified": "2023-01-13T13:39:24.450Z"}, {"entity": "publication", "iuid": "e629e0b88f764cb6a5e5e0616bead01b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e629e0b88f764cb6a5e5e0616bead01b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e629e0b88f764cb6a5e5e0616bead01b"}}, "title": "Safeguarding people living in vulnerable conditions in the COVID-19 era through universal health coverage and social protection.", "authors": [{"family": "Barron", "given": "Gabriela Cuevas", "initials": "GC"}, {"family": "Laryea-Adjei", "given": "George", "initials": "G"}, {"family": "Vike-Freiberga", "given": "Vaira", "initials": "V"}, {"family": "Abubakar", "given": "Ibrahim", "initials": "I"}, {"family": "Dakkak", "given": "Henia", "initials": "H"}, {"family": "Devakumar", "given": "Delanjathan", "initials": "D"}, {"family": "Johnsson", "given": "Anders", "initials": "A"}, {"family": "Karabey", "given": "Selma", "initials": "S"}, {"family": "Labont\u00e9", "given": "Ronald", "initials": "R"}, {"family": "Legido-Quigley", "given": "Helena", "initials": "H"}, {"family": "Lloyd-Sherlock", "given": "Peter", "initials": "P"}, {"family": "Olufadewa", "given": "Isaac Iyinoluwa", "initials": "II"}, {"family": "Ray", "given": "Harold Calvin", "initials": "HC"}, {"family": "Redlener", "given": "Irwin", "initials": "I"}, {"family": "Redlener", "given": "Karen", "initials": "K"}, {"family": "Serageldin", "given": "Ismail", "initials": "I"}, {"family": "Lima", "given": "Nisia Trindade", "initials": "NT"}, {"family": "Viana", "given": "Virgilio", "initials": "V"}, {"family": "Zappone", "given": "Katherine", "initials": "K"}, {"family": "Huynh", "given": "Uyen Kim", "initials": "UK"}, {"family": "Schlosberg", "given": "Nicole", "initials": "N"}, {"family": "Sun", "given": "Hanlu", "initials": "H"}, {"family": "Karadag", "given": "Ozge", "initials": "O"}, {"family": "Lancet Commission on COVID-19: Task Force on Humanitarian Relief, Social Protection and Vulnerable Groups", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-10", "journal": {"title": "Lancet Public Health", "issn": "2468-2667", "issn-l": null}, "abstract": "The COVID-19 pandemic is unprecedented. The pandemic not only induced a public health crisis, but has led to severe economic, social, and educational crises. Across economies and societies, the distributional consequences of the pandemic have been uneven. Among groups living in vulnerable conditions, the pandemic substantially magnified the inequality gaps, with possible negative implications for these individuals' long-term physical, socioeconomic, and mental wellbeing. This Viewpoint proposes priority, programmatic, and policy recommendations that governments, resource partners, and relevant stakeholders should consider in formulating medium-term to long-term strategies for preventing the spread of COVID-19, addressing the virus's impacts, and decreasing health inequalities. The world is at a never more crucial moment, requiring collaboration and cooperation from all sectors to mitigate the inequality gaps and improve people's health and wellbeing with universal health coverage and social protection, in addition to implementation of the health in all policies approach.", "doi": "10.1016/S2468-2667(21)00235-8", "pmid": "34906331", "labels": {"Type: Review": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2468-2667(21)00235-8"}, {"db": "pmc", "key": "PMC8665842"}], "notes": [], "created": "2021-12-18T17:54:05.429Z", "modified": "2021-12-18T17:54:05.441Z"}, {"entity": "publication", "iuid": "57212c7f13c042b986a0532a73c0e0c1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/57212c7f13c042b986a0532a73c0e0c1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/57212c7f13c042b986a0532a73c0e0c1"}}, "title": "Infectious complications and vaccines", "authors": [{"family": "Ljungman", "given": "Per", "initials": "P"}], "type": "journal-article", "published": "2021-12-10", "journal": {"issn": "1520-4391", "volume": "2021", "issue": "1", "pages": "587-591", "issn-l": null}, "abstract": null, "doi": "10.1182/hematology.2021000294", "pmid": null, "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:51:52.783Z", "modified": "2021-12-12T06:51:52.898Z"}, {"entity": "publication", "iuid": "0a34a24ce00441bc96f56bc382e194e3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a34a24ce00441bc96f56bc382e194e3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a34a24ce00441bc96f56bc382e194e3"}}, "title": "The Depression: Online Therapy Study (D:OTS)-A Pilot Study of an Internet-Based Psychodynamic Treatment for Adolescents with Low Mood in the UK, in the Context of the COVID-19 Pandemic.", "authors": [{"family": "Midgley", "given": "Nick", "initials": "N"}, {"family": "Guerrero-Tates", "given": "Brenda", "initials": "B", "orcid": "0000-0001-6329-7444", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b32ab4ed632f47f9863ccc50421e02c1.json"}}, {"family": "Mortimer", "given": "Rose", "initials": "R"}, {"family": "Edbrooke-Childs", "given": "Julian", "initials": "J"}, {"family": "Mechler", "given": "Jakob", "initials": "J", "orcid": "0000-0002-1296-3432", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69054a3745b04d12b759a754b88148c7.json"}}, {"family": "Lindqvist", "given": "Karin", "initials": "K"}, {"family": "Hajkowski", "given": "Susan", "initials": "S"}, {"family": "Leibovich", "given": "Liat", "initials": "L"}, {"family": "Martin", "given": "Peter", "initials": "P", "orcid": "0000-0003-4638-0638", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f85a19380ba34972a839e5453514ae65.json"}}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Vlaescu", "given": "George", "initials": "G"}, {"family": "Lilliengren", "given": "Peter", "initials": "P"}, {"family": "Kitson", "given": "Annabel", "initials": "A"}, {"family": "Butler-Wheelhouse", "given": "Pamela", "initials": "P"}, {"family": "Philips", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2021-12-09", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "24", "issn-l": null}, "abstract": "Introduction: Face-to-face therapy is unavailable to many young people with mental health difficulties in the UK. Internet-based treatments are a low-cost, flexible, and accessible option that may be acceptable to young people. This pilot study examined the feasibility, acceptability and effectiveness of an English-language adaptation of internet-based psychodynamic treatment (iPDT) for depressed adolescents, undertaken during the COVID-19 pandemic in the UK. Methods: A single-group, uncontrolled design was used. A total of 23 adolescents, 16-18 years old and experiencing depression, were recruited to this study. Assessments were made at baseline and end of treatment, with additional weekly assessments of depression and anxiety symptoms. Results: Findings showed that it was feasible to recruit to this study during the pandemic, and to deliver the iPDT model with a good level of treatment acceptability. A statistically significant reduction in depressive symptoms and emotion dysregulation was found, with large effect size, by the end of treatment. Whilst anxiety symptoms decreased, this did not reach statistical significance. Conclusions: The findings suggest that this English-language adaptation of iPDT, with some further revisions, is feasible to deliver and acceptable for adolescents with depression. Preliminary data indicate that iPDT appears to be effective in reducing depressive symptoms in adolescents.", "doi": "10.3390/ijerph182412993", "pmid": "34948601", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182412993"}, {"db": "pmc", "key": "PMC8702018"}], "notes": [], "created": "2022-01-04T15:31:18.484Z", "modified": "2022-01-04T15:31:26.495Z"}, {"entity": "publication", "iuid": "75c2e73874374773acdbf004d6dba2a8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/75c2e73874374773acdbf004d6dba2a8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/75c2e73874374773acdbf004d6dba2a8"}}, "title": "Surveillance of COVID-19 vaccine effectiveness \u2013 a real-time case-control study in southern Sweden", "authors": [{"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J", "orcid": "0000-0003-1883-2000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e88fdca336ae41c891f0a46e2481b67f.json"}}, {"family": "Bonander", "given": "Carl", "initials": "C", "orcid": "0000-0002-1189-9950", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/386ac82b1a4843828b503ec807c08206.json"}}, {"family": "Moghaddassi", "given": "Mahnaz", "initials": "M", "orcid": "0000-0002-0844-4736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a219bde5ba8a4f3f8655ada08d749885.json"}}, {"family": "Rasmussen", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1588-5473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c760e8d21ae441ba236f86e6185d392.json"}}, {"family": "Malmqvist", "given": "Ulf", "initials": "U"}, {"family": "Kahn", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-5566-6350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42eda71f3775400599febc10a4e7359c.json"}}, {"family": "Inghammar", "given": "Malin", "initials": "M", "orcid": "0000-0003-2995-1312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4ab710428614cccb2a537ecab31d0a0.json"}}], "type": "posted-content", "published": "2021-12-09", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.12.09.21267515", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:47:57.738Z", "modified": "2022-01-04T15:47:57.811Z"}, {"entity": "publication", "iuid": "2c51df9483e84e5582c25da75f2caf02", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c51df9483e84e5582c25da75f2caf02.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c51df9483e84e5582c25da75f2caf02"}}, "title": "Indirect effects of COVID-19 on the environment: How deep and how long?", "authors": [{"family": "Vadiati", "given": "Meysam", "initials": "M"}, {"family": "Beynaghi", "given": "Ali", "initials": "A"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Bandala", "given": "Erick R", "initials": "ER"}, {"family": "Mozafari", "given": "Masoud", "initials": "M"}], "type": "journal article", "published": "2021-12-09", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "pages": "152255", "issn-l": "0048-9697"}, "abstract": "Although the World Health Organization (WHO) announcement released in early March 2020 stated there is no proven evidence that the COVID-19 virus can survive in drinking water or sewage, there has been some recent evidence that coronaviruses can survive in low-temperature environments and in groundwater for more than a week. Some studies have also found SARS-CoV-2 genetic materials in raw municipal wastewater, which highlights a potential avenue for viral spread. A lack of information about the presence and spread of COVID-19 in the environment may lead to decisions based on local concerns and prevent the integration of the prevalence of SARS-CoV-2 into the global water cycle. Several studies have optimistically assumed that coronavirus has not yet affected water ecosystems, but this assumption may increase the possibility of subsequent global water issues. More studies are needed to provide a comprehensive picture of COVID-19 occurrence and outbreak in aquatic environments and more specifically in water resources. As scientific efforts to report reliable news, conduct rapid and precise research on COVID-19, and advocate for scientists worldwide to overcome this crisis increase, more information is required to assess the extent of the effects of the COVID-19 pandemic on the environment. The goals of this study are to estimate the extent of the environmental effects of the pandemic, as well as identify related knowledge gaps and avenues for future research.", "doi": "10.1016/j.scitotenv.2021.152255", "pmid": "34896489", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(21)07331-9"}, {"db": "pmc", "key": "PMC8660132"}], "notes": [], "created": "2021-12-18T18:02:36.372Z", "modified": "2021-12-18T18:02:36.384Z"}, {"entity": "publication", "iuid": "9f7d2dc2f2ba4d5f814c6b9181f721b6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f7d2dc2f2ba4d5f814c6b9181f721b6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f7d2dc2f2ba4d5f814c6b9181f721b6"}}, "title": "Increasing risk of breakthrough COVID-19 in outbreaks with high attack rates in European long-term care facilities, July to October 2021", "authors": [{"family": "Suetens", "given": "Carl", "initials": "C"}, {"family": "Kinross", "given": "Pete", "initials": "P"}, {"family": "Gallego Berciano", "given": "Pilar", "initials": "P"}, {"family": "Arroyo Nebreda", "given": "Virginia", "initials": "V"}, {"family": "Hassan", "given": "Eline", "initials": "E"}, {"family": "Calba", "given": "Cl\u00e9mentine", "initials": "C"}, {"family": "Fernandes", "given": "Eugenia", "initials": "E"}, {"family": "Peralta-Santos", "given": "Andre", "initials": "A"}, {"family": "Casaca", "given": "Pedro", "initials": "P"}, {"family": "Shodu", "given": "Nathalie", "initials": "N"}, {"family": "Dequeker", "given": "Sara", "initials": "S"}, {"family": "Kontopidou", "given": "Flora", "initials": "F"}, {"family": "Pappa", "given": "Lamprini", "initials": "L"}, {"family": "Kacelnik", "given": "Oliver", "initials": "O"}, {"family": "B\u00f8rseth", "given": "Anita Wang", "initials": "AW"}, {"family": "O\u2019Connor", "given": "Lois", "initials": "L"}, {"family": "Garvey", "given": "Patricia", "initials": "P"}, {"family": "Liausedien\u0117", "given": "Rasa", "initials": "R"}, {"family": "Valintelien\u0117", "given": "Rolanda", "initials": "R"}, {"family": "Ernst", "given": "Corinna", "initials": "C"}, {"family": "Mossong", "given": "Jo\u00ebl", "initials": "J"}, {"family": "\u0160tefkovi\u010dov\u00e1", "given": "M\u00e1ria", "initials": "M"}, {"family": "Prostin\u00e1kov\u00e1", "given": "Zuzana", "initials": "Z"}, {"family": "Danielsen", "given": "Ann Caroline", "initials": "AC"}, {"family": "Mougkou", "given": "Aikaterini", "initials": "A"}, {"family": "Lamb", "given": "Favelle", "initials": "F"}, {"family": "Cenciarelli", "given": "Orlando", "initials": "O"}, {"family": "Monnet", "given": "Dominique L", "initials": "DL"}, {"family": "Plachouras", "given": "Diamantis", "initials": "D"}], "type": "journal-article", "published": "2021-12-09", "journal": {"issn": "1560-7917", "volume": "26", "issue": "49", "title": "Euro Surveill", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.es.2021.26.49.2101070", "pmid": null, "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:55:12.065Z", "modified": "2021-12-12T06:55:12.078Z"}, {"entity": "publication", "iuid": "50574c4460054f4bac0c05e7f605b4f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50574c4460054f4bac0c05e7f605b4f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50574c4460054f4bac0c05e7f605b4f7"}}, "title": "Autoantibodies and infection with SARS-CoV2 infection: The spectrum from association to clinical implicationreport of the 15th Dresden symposium on autoantibodies.", "authors": [{"family": "Damoiseaux", "given": "Jan", "initials": "J"}, {"family": "Dotan", "given": "Arad", "initials": "A"}, {"family": "Fritzler", "given": "Marvin J", "initials": "MJ"}, {"family": "Bogdanos", "given": "Dimitrios P", "initials": "DP"}, {"family": "Meroni", "given": "Pier Luigi", "initials": "PL"}, {"family": "Roggenbuck", "given": "Dirk", "initials": "D"}, {"family": "Goldman", "given": "Michel", "initials": "M"}, {"family": "Landegren", "given": "Nils", "initials": "N"}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Shoenfeld", "given": "Yehuda", "initials": "Y"}, {"family": "Conrad", "given": "Karsten", "initials": "K"}], "type": "journal article", "published": "2021-12-09", "journal": {"title": "Autoimmun Rev", "issn": "1873-0183", "pages": "103012", "issn-l": null}, "abstract": "The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Symposium on Autoantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting.", "doi": "10.1016/j.autrev.2021.103012", "pmid": "34896650", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1568-9972(21)00294-9"}, {"db": "pmc", "key": "PMC8656211"}], "notes": [], "created": "2021-12-18T18:01:27.322Z", "modified": "2021-12-18T18:01:36.807Z"}, {"entity": "publication", "iuid": "ea1e1a34cf7d4dabbd5a5918e7571cbd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ea1e1a34cf7d4dabbd5a5918e7571cbd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ea1e1a34cf7d4dabbd5a5918e7571cbd"}}, "title": "Convalescent plasma treatment in severely immunosuppressed patients hospitalized with COVID-19: an observational study of 28 cases.", "authors": [{"family": "Ljungquist", "given": "Oskar", "initials": "O"}, {"family": "Lundgren", "given": "Maria", "initials": "M"}, {"family": "Iliachenko", "given": "Elena", "initials": "E"}, {"family": "M\u00e5nsson", "given": "Fredrik", "initials": "F"}, {"family": "B\u00f6ttiger", "given": "Blenda", "initials": "B"}, {"family": "Landin-Olsson", "given": "Mona", "initials": "M"}, {"family": "Wik\u00e9n", "given": "Christian", "initials": "C"}, {"family": "Rosendal", "given": "Ebba", "initials": "E"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "Wigren", "given": "Bystr\u00f6m J", "initials": "BJ"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Kjeldsen-Kragh", "given": "Jens", "initials": "J"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1588-5473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c760e8d21ae441ba236f86e6185d392.json"}}, {"family": "Kahn", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-5566-6350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42eda71f3775400599febc10a4e7359c.json"}}, {"family": "Holm", "given": "Karin", "initials": "K", "orcid": "0000-0002-8289-5949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7f590df41084ab28d7a1ac80b1b90e7.json"}}], "type": "journal article", "published": "2021-12-08", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "pages": "1-9", "issn-l": "2374-4235"}, "abstract": "Immunosuppressed patients are particularly vulnerable to severe infection from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), risking prolonged viremia and symptom duration. In this study we describe clinical and virological treatment outcomes in a heterogeneous group of patients with severe immunosuppression due to various causes suffering from COVID-19 infection, who were all treated with convalescent plasma (CCP) along with standard treatment.\n\nWe performed an observational, retrospective case series between May 2020 to March 2021 at three sites in Sk\u00e5ne, Sweden, with a population of nearly 1.4 million people. All patients hospitalized for COVID-19 who received CCP with the indication severe immunosuppression as defined by the treating physician were included in the study (n = 28).\n\nIn total, 28 severely immunocompromised patients, half of which previously had been treated with rituximab, who had received in-hospital convalescent plasma treatment of COVID-19 were identified. One week after CCP treatment, 13 of 28 (46%) patients had improved clinically defined as a decrease of at least one point at the WHO-scale. Three patients had increased score points of whom two had died. For 12 patients, the WHO-scale was unchanged.\n\nAs one of only few studies on CCP treatment of COVID-19 in hospitalized patients with severe immunosuppression, this study adds descriptive data. The study design prohibits conclusions on safety and efficacy, and the results should be interpreted with caution. Prospective, randomized trials are needed to investigate this further.", "doi": "10.1080/23744235.2021.2013528", "pmid": "34878955", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-12T07:15:43.946Z", "modified": "2021-12-12T07:15:44.023Z"}, {"entity": "publication", "iuid": "cc31f7e80cd84d1eb9ef8e03aa706616", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc31f7e80cd84d1eb9ef8e03aa706616.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc31f7e80cd84d1eb9ef8e03aa706616"}}, "title": "What a Pandemic Has Taught Us About the Potential for Innovation in Rural Health: Commencing an Ethnography in Canada, the United States, Sweden, and Australia.", "authors": [{"family": "Petrie", "given": "Samuel", "initials": "S"}, {"family": "Carson", "given": "Dean", "initials": "D"}, {"family": "Peters", "given": "Paul", "initials": "P"}, {"family": "Hurtig", "given": "Anna-Karin", "initials": "AK"}, {"family": "LeBlanc", "given": "Michele", "initials": "M"}, {"family": "Simpson", "given": "Holly", "initials": "H"}, {"family": "Barnabe", "given": "Jaymie", "initials": "J"}, {"family": "Young", "given": "Mikayla", "initials": "M"}, {"family": "Ostafichuk", "given": "Mara", "initials": "M"}, {"family": "Hodge", "given": "Heidi", "initials": "H"}, {"family": "Gladman", "given": "Justin", "initials": "J"}, {"family": "Smale", "given": "Matilda", "initials": "M"}, {"family": "Gonzalez Garcia", "given": "Manueal", "initials": "M"}], "type": "journal article", "published": "2021-12-07", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "768624", "issn-l": "2296-2565"}, "abstract": "The COVID-19 pandemic coincided with a multi-national federally funded research project examining the potential for health and care services in small rural areas to identify and implement innovations in service delivery. The project has a strong focus on electronic health (eHealth) but covers other areas of innovation as well. The project has been designed as an ethnography to prelude a realist evaluation, asking the question under what conditions can local health and care services take responsibility for designing and implementing new service models that meet local needs? The project had already engaged with several health care practitioners and research students based in Canada, Sweden, Australia, and the United States. Our attention is particularly on rural communities with fewer than 5,000 residents and which are relatively isolated from larger service centres. Between March and September 2020, the project team undertook ethnographic and auto-ethnographic research in their own communities to investigate what the service model responses to the pandemic were, and the extent to which local service managers were able to customize their responses to suit the needs of their communities. An initial program theory drawn from the extant literature suggested that \"successful\" response to the pandemic would depend on a level of local autonomy, \"absorptive capacity,*\" strong service-community connections, an \"anti-fragile\u2020\" approach to implementing change, and a realistic recognition of the historical barriers to implementing eHealth and other innovations in these types of rural communities. The field research in 2020 has refined the theory by focusing even more attention on absorptive capacity and community connections, and by suggesting that some level of ignorance of the barriers to innovation may be beneficial. The research also emphasized the role and power of external actors to the community which had not been well-explored in the literature. This paper will summarize both what the field research revealed about the capacity to respond well to the COVID-19 challenge and highlight the gaps in innovative strategies at a managerial level required for rapid response to system stress. *Absorptive Capacity is defined as the ability of an organization (community, clinic, hospital) to adapt to change. Organizations with flexible capacity can incorporate change in a productive fashion, while those with rigid capacity take longer to adapt, and may do so inappropriately. \u2020Antifragility is defined as an entities' ability to gain stability through stress. Biological examples include building muscle through consistent use, and bones becoming stronger through subtle stress. Antifragility has been used as a guiding principle in programme implementation in the past.", "doi": "10.3389/fpubh.2021.768624", "pmid": "34950628", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8688687"}], "notes": [], "created": "2022-01-04T15:27:50.199Z", "modified": "2022-01-04T15:27:50.212Z"}, {"entity": "publication", "iuid": "052ca3e645354ab7a97015a64dd0b35e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/052ca3e645354ab7a97015a64dd0b35e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/052ca3e645354ab7a97015a64dd0b35e"}}, "title": "Training the trainers: Finding new educational opportunities in the virtual world.", "authors": [{"family": "Baessler", "given": "Franziska", "initials": "F", "orcid": "0000-0001-7280-9675", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8397969848e4bbf90e3b54df39bdb1b.json"}}, {"family": "Sartorius", "given": "Norman", "initials": "N", "orcid": "0000-0001-8708-6289", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04897447954f4336ae2d7f094bbc4571.json"}}, {"family": "Javed", "given": "Afzal", "initials": "A", "orcid": "0000-0003-2518-0688", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c17ce249596343c78ae97f5a7c68c916.json"}}, {"family": "Tasman", "given": "Allan", "initials": "A"}, {"family": "Coskun", "given": "Bulent", "initials": "B", "orcid": "0000-0002-6381-8120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba8f859894574029adfc05e94b15f5f5.json"}}, {"family": "Frydecka", "given": "Dorota", "initials": "D", "orcid": "0000-0001-8582-9958", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd965f723ffb48b283e8e318b6baba75.json"}}, {"family": "Kazakova", "given": "Olga", "initials": "O", "orcid": "0000-0003-3261-3429", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8434c5d25ce64f048f4b8b56b2ec3a9d.json"}}, {"family": "Sampogna", "given": "Gaia", "initials": "G", "orcid": "0000-0002-9547-2793", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8aa29f1af234c24b093c46f4cad7a22.json"}}, {"family": "Zhabenko", "given": "Olena", "initials": "O", "orcid": "0000-0001-7986-2970", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e133dad8f94e43b8be67aebe6af4ba3e.json"}}, {"family": "Koelkebeck", "given": "Katja", "initials": "K", "orcid": "0000-0002-0469-3997", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/63a95a4ddeca4835afd611a064d3dacf.json"}}, {"family": "Hepdurgun", "given": "Cenan", "initials": "C", "orcid": "0000-0002-2809-0277", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8bdd4d5544674a94a6418472283e5648.json"}}, {"family": "Zafar", "given": "Ali", "initials": "A", "orcid": "0000-0002-1305-7407", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3834361e7e34408890e0889c9dc6668e.json"}}, {"family": "Fiorillo", "given": "Andrea", "initials": "A", "orcid": "0000-0002-6926-0762", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89a321877c9049918b8fec9cd5b09c84.json"}}], "type": "journal article", "published": "2021-12-07", "journal": {"title": "Asia Pac Psychiatry", "issn": "1758-5872", "pages": "e12499", "issn-l": null}, "abstract": "The COVID-19 pandemic has disrupted scientific gatherings and conferences, opening up opportunities for virtual learning platforms. Realizing the potential of online academic exchanges, the World Psychiatric Association (WPA) also developed virtual avenues and information systems for capacity building of mental health professionals across the world. Among its first such initiatives, the WPA organized a virtual Train the Trainers workshop, where 123 psychiatrists, psychiatric trainees, and educators from 45 countries participated. The innovative and interactive workshop allowed participants to get to know each other, exchange educational and professional experiences, and ask questions or receive advice from experts. Keynote speakers, including WPA President Prof. Afzal Javed and Prof. Norman Sartorius, stressed upon the importance of finding innovative solutions in psychiatry training and the need to improve teaching and training in the field of psychiatry, especially in the provision of leadership and communication skills. Online training methods can provide easy access to academics and students while reducing the organizational and logistical costs. They have the potential to improve educational equality and allow the voice of the underprivileged scientists to be heard across the globe. The devastating impact on access to mental health services during COVID-19 underscores the urgent need for online training, particularly in countries where the ratio of psychiatrists to patients is inadequate and doctors concentrate more on treatment than on research and education. Virtual educational interventions could prove incredibly useful in the future just as they are being successfully utilized in local and regional contexts during the pandemic.", "doi": "10.1111/appy.12499", "pmid": "34873842", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-12-12T07:10:44.650Z", "modified": "2021-12-12T07:10:45.043Z"}, {"entity": "publication", "iuid": "8e1f894a5f5249e5961aebb3314dfbfd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e1f894a5f5249e5961aebb3314dfbfd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e1f894a5f5249e5961aebb3314dfbfd"}}, "title": "Resilience in care organisations: challenges in maintaining support for vulnerable people in Europe during the Covid-19 pandemic.", "authors": [{"family": "Orru", "given": "Kati", "initials": "K"}, {"family": "Nero", "given": "Kristi", "initials": "K"}, {"family": "Naevestad", "given": "Tor-Olav", "initials": "TO"}, {"family": "Schieffelers", "given": "Abriel", "initials": "A"}, {"family": "Olson", "given": "Alexandra", "initials": "A"}, {"family": "Airola", "given": "Merja", "initials": "M"}, {"family": "Kazemekaityte", "given": "Austeja", "initials": "A"}, {"family": "Lovasz", "given": "Gabriella", "initials": "G"}, {"family": "Scurci", "given": "Giuseppe", "initials": "G"}, {"family": "Ludvigsen", "given": "Johanna", "initials": "J"}, {"family": "de Los Rios P\u00e9rez", "given": "Daniel A", "initials": "DA"}], "type": "journal article", "published": "2021-12-07", "journal": {"title": "Disasters", "issn": "1467-7717", "issn-l": null}, "abstract": "The Covid-19 pandemic has challenged the resilience of care organisations (and those dependent on them), especially when services are stopped or restricted. This study focuses on the experiences of care organisations that offer services to individuals in highly precarious situations in 10 European countries. It is based on 32 qualitative interviews and three workshops with managers and staff. The four key types of organisations reviewed largely had the same adaptation patterns in all countries. The most drastic changes were experienced by day centres, which had to suspend or digitise services, whereas night shelters and soup kitchens had to reorganise broadly their work; residential facilities were minimally affected. Given the drastic surge in demand for services, reliance on an overburdened (volunteer) workforce, and a lack of crisis plans, the care organisations with long-term trust networks with clients and intra-organisational cooperation adapted easier. The outcomes were worse for new clients, migrants, psychologically vulnerable people, and those with limited communicative abilities.", "doi": "10.1111/disa.12526", "pmid": "34874082", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-12-12T07:11:20.679Z", "modified": "2021-12-12T07:11:36.858Z"}, {"entity": "publication", "iuid": "a9889a45330745ef9afbcd594c736357", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a9889a45330745ef9afbcd594c736357.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a9889a45330745ef9afbcd594c736357"}}, "title": "Plasma Proteome Fingerprints Reveal Distinctiveness and Clinical Outcome of SARS-CoV-2 Infection.", "authors": [{"family": "Bauer", "given": "Wolfgang", "initials": "W", "orcid": "0000-0002-1063-3237", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae14a94fec6e47a58fb0571d872eb474.json"}}, {"family": "Weber", "given": "Marcus", "initials": "M"}, {"family": "Diehl-Wiesenecker", "given": "Eva", "initials": "E"}, {"family": "Galtung", "given": "Noa", "initials": "N", "orcid": "0000-0002-4379-9516", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/afc2ffad4bff4f3bbddc701f06254b53.json"}}, {"family": "Prpic", "given": "Monika", "initials": "M"}, {"family": "Somasundaram", "given": "Rajan", "initials": "R"}, {"family": "Tauber", "given": "Rudolf", "initials": "R"}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67a59fa5de37434c8b7151039c192a37.json"}}, {"family": "Micke", "given": "Patrick", "initials": "P", "orcid": "0000-0003-1210-5961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24f9f5e6c72d414b869d2adeed4b9951.json"}}, {"family": "Kappert", "given": "Kai", "initials": "K", "orcid": "0000-0001-6976-0428", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/803023090ed64c3eb77f84a84d561c67.json"}}], "type": "journal article", "published": "2021-12-07", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "13", "issue": "12", "pages": "2456"}, "abstract": "We evaluated how plasma proteomic signatures in patients with suspected COVID-19 can unravel the pathophysiology, and determine kinetics and clinical outcome of the infection.\r\n\r\nPlasma samples from patients presenting to the emergency department (ED) with symptoms of COVID-19 were stratified into: (1) patients with suspected COVID-19 that was not confirmed (n = 44); (2) non-hospitalized patients with confirmed COVID-19 (n = 44); (3) hospitalized patients with confirmed COVID-19 (n = 53) with variable outcome; and (4) patients presenting to the ED with minor diseases unrelated to SARS-CoV-2 infection (n = 20). Besides standard of care diagnostics, 177 circulating proteins related to inflammation and cardiovascular disease were analyzed using proximity extension assay (PEA, Olink) technology.\r\n\r\nComparative proteome analysis revealed 14 distinct proteins as highly associated with SARS-CoV-2 infection and 12 proteins with subsequent hospitalization (p < 0.001). ADM, IL-6, MCP-3, TRAIL-R2, and PD-L1 were each predictive for death (AUROC curve 0.80-0.87). The consistent increase of these markers, from hospital admission to intensive care and fatality, supported the concept that these proteins are of major clinical relevance.\r\n\r\nWe identified distinct plasma proteins linked to the presence and course of COVID-19. These plasma proteomic findings may translate to a protein fingerprint, helping to assist clinical management decisions.", "doi": "10.3390/v13122456", "pmid": "34960725", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Drug discovery and repurposing of drugs": null}, "xrefs": [{"db": "pii", "key": "v13122456"}, {"db": "pmc", "key": "PMC8706135"}], "notes": [], "created": "2021-12-18T18:26:19.356Z", "modified": "2022-01-04T15:50:46.848Z"}, {"entity": "publication", "iuid": "2fe18e9c5e8a46e291d0c66359a4a8f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2fe18e9c5e8a46e291d0c66359a4a8f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2fe18e9c5e8a46e291d0c66359a4a8f8"}}, "title": "Imiquimod Boosts Interferon Response, and Decreases ACE2 and Pro-Inflammatory Response of Human Bronchial Epithelium in Asthma.", "authors": [{"family": "Nieto-Fontarigo", "given": "Juan Jos\u00e9", "initials": "JJ"}, {"family": "Tillgren", "given": "Sofia", "initials": "S"}, {"family": "Cerps", "given": "Samuel", "initials": "S"}, {"family": "Sverrild", "given": "Asger", "initials": "A"}, {"family": "Hvidtfeldt", "given": "Morten", "initials": "M"}, {"family": "Ramu", "given": "Sangeetha", "initials": "S"}, {"family": "Menzel", "given": "Mandy", "initials": "M"}, {"family": "Sander", "given": "Adam Frederik", "initials": "AF"}, {"family": "Porsbjerg", "given": "Celeste", "initials": "C"}, {"family": "Uller", "given": "Lena", "initials": "L"}], "type": "journal article", "published": "2021-12-07", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "12", "pages": "743890", "issn-l": "1664-3224"}, "abstract": "Both anti-viral and anti-inflammatory bronchial effects are warranted to treat viral infections in asthma. We sought to investigate if imiquimod, a TLR7 agonist, exhibits such dual actions in ex vivo cultured human bronchial epithelial cells (HBECs), targets for SARS-CoV-2 infectivity.\n\nTo investigate bronchial epithelial effects of imiquimod of potential importance for anti-viral treatment in asthmatic patients.\n\nEffects of imiquimod alone were examined in HBECs from healthy (N=4) and asthmatic (N=18) donors. Mimicking SARS-CoV-2 infection, HBECs were stimulated with poly(I:C), a dsRNA analogue, or SARS-CoV-2 spike-protein 1 (SP1; receptor binding) with and without imiquimod treatment. Expression of SARS-CoV-2 receptor (ACE2), pro-inflammatory and anti-viral cytokines were analyzed by RT-qPCR, multiplex ELISA, western blot, and Nanostring and proteomic analyses.\n\nImiquimod reduced ACE2 expression at baseline and after poly(I:C) stimulation. Imiquimod also reduced poly(I:C)-induced pro-inflammatory cytokines including IL-1\u03b2, IL-6, IL-8, and IL-33. Furthermore, imiquimod increased IFN-\u03b2 expression, an effect potentiated in presence of poly(I:C) or SP1. Multiplex mRNA analysis verified enrichment in type-I IFN signaling concomitant with suppression of cytokine signaling pathways induced by imiquimod in presence of poly(I:C). Exploratory proteomic analyses revealed potentially protective effects of imiquimod on infections.\n\nImiquimod triggers viral resistance mechanisms in HBECs by decreasing ACE2 and increasing IFN-\u03b2 expression. Additionally, imiquimod improves viral infection tolerance by reducing viral stimulus-induced epithelial cytokines involved in severe COVID-19 infection. Our imiquimod data highlight feasibility of producing pluripotent drugs potentially suited for anti-viral treatment in asthmatic subjects.", "doi": "10.3389/fimmu.2021.743890", "pmid": "34950134", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8688760"}], "notes": [], "created": "2022-01-04T15:28:07.292Z", "modified": "2022-01-04T15:28:07.306Z"}, {"entity": "publication", "iuid": "635c7b339a06434fa64ae02072cf14ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/635c7b339a06434fa64ae02072cf14ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/635c7b339a06434fa64ae02072cf14ef"}}, "title": "An observational study of intermediate or high dose thromboprophylaxis for critically ill COVID-19 patients.", "authors": [{"family": "Jonmarker", "given": "Sandra", "initials": "S", "orcid": "0000-0001-5836-8594", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d28ab27b84f40e2b3d57c91595ece92.json"}}, {"family": "Litorell", "given": "Jacob", "initials": "J"}, {"family": "Dahlberg", "given": "Martin", "initials": "M"}, {"family": "Stackelberg", "given": "Otto", "initials": "O"}, {"family": "Everhov", "given": "\u00c5sa H", "initials": "\u00c5H"}, {"family": "S\u00f6derberg", "given": "M\u00e5rten", "initials": "M"}, {"family": "Rubenson-Wahlin", "given": "Rebecka", "initials": "R"}, {"family": "G\u00fcnther", "given": "Mattias", "initials": "M", "orcid": "0000-0003-2372-6114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9150a7883334344ba7c4abfbe273fef.json"}}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}, {"family": "Hollenberg", "given": "Jacob", "initials": "J"}, {"family": "Joelsson-Alm", "given": "Eva", "initials": "E", "orcid": "0000-0002-9041-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07a091265e654b21bc27fa14b93e4ec0.json"}}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-12-07", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172"}, "abstract": "Critically ill COVID-19 patients have a high reported incidence of thromboembolic complications and the optimal dose of thromboprophylaxis is not yet determined. The aim of this study was to investigate if 90-day mortality differed between patients treated with intermediate or high dose thromboprophylaxis.\n\nIn this retrospective study, all critically ill COVID-19 patients admitted to intensive care from March 6 until July 15, 2020, were eligible. Patients were categorized into groups according to daily dose of thromboprophylaxis. Dosing was based on local standardized recommendations, not on degree of critical illness or risk of thrombosis. Cox proportional hazards regression was used to estimate hazard ratios of death within 90 days from ICU admission. Multivariable models were adjusted for sex, age, body-mass index, Simplified Acute Physiology Score III, invasive respiratory support, glucocorticoids, and dosing strategy of thromboprophylaxis.\n\nA total of 165 patients were included; 92 intermediate and 73 high dose thromboprophylaxis. Baseline characteristics did not differ between groups. The 90-day mortality was 19.6% in patients with intermediate dose and 19.2% in patients with high dose thromboprophylaxis. Multivariable hazard ratio of death within 90 days was 0.74 (95% CI, 0.36-1.53) for the high dose group compared to intermediate dose group. Multivariable hazard ratio for thromboembolic events and bleedings within 28 days were 0.93 (95% CI 0.37-2.29) and 0.84 (95% CI 0.28-2.54) for high versus intermediate dose, respectively.\n\nA difference in 90-day mortality between intermediate and high dose thromboprophylaxis could neither be confirmed nor rejected due to a small sample size.", "doi": "10.1111/aas.14013", "pmid": "34875111", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-12T07:14:59.689Z", "modified": "2021-12-12T07:14:59.804Z"}, {"entity": "publication", "iuid": "ceb2eb041f8846e2909fc611030c9123", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ceb2eb041f8846e2909fc611030c9123.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ceb2eb041f8846e2909fc611030c9123"}}, "title": "1H, 13C and 15N resonance assignment of the SARS-CoV-2 full-length nsp1 protein and its mutants reveals its unique secondary structure features in solution.", "authors": [{"family": "Agback", "given": "Tatiana", "initials": "T"}, {"family": "Dominguez", "given": "Francisco", "initials": "F"}, {"family": "Frolov", "given": "Ilya", "initials": "I"}, {"family": "Frolova", "given": "Elena I", "initials": "EI"}, {"family": "Agback", "given": "Peter", "initials": "P", "orcid": "0000-0003-2226-0746", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/660f06a0871c4d87a362f2a7dbf1dc98.json"}}], "type": "journal article", "published": "2021-12-07", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "12", "pages": "e0251834", "issn-l": "1932-6203"}, "abstract": "Structural characterization of the SARS-CoV-2 full length nsp1 protein will be an essential tool for developing new target-directed antiviral drugs against SARS-CoV-2 and for further understanding of intra- and intermolecular interactions of this protein. As a first step in the NMR studies of the protein, we report the 1H, 13C and 15N resonance backbone assignment as well as the C\u03b2 of the apo form of the full-lengthSARS-CoV-2 nsp1 including the folded domain together with the flaking N- and C- terminal intrinsically disordered fragments. The 19.8 kD protein was characterized by high-resolution NMR. Validation of assignment have been done by using two different mutants, H81P and K129E/D48E as well as by amino acid specific experiments. According to the obtained assignment, the secondary structure of the folded domain in solution was almost identical to its previously published X-ray structure as well as another published secondary structure obtained by NMR, but some discrepancies have been detected. In the solution SARS-CoV-2 nsp1 exhibited disordered, flexible N- and C-termini with different dynamic characteristics. The short peptide in the beginning of the disordered C-terminal domain adopted two different conformations distinguishable on the NMR time scale. We propose that the disordered and folded nsp1 domains are not fully independent units but are rather involved in intramolecular interactions. Studies of the structure and dynamics of the SARS-CoV-2 mutant in solution are on-going and will provide important insights into the molecular mechanisms underlying these interactions.", "doi": "10.1371/journal.pone.0251834", "pmid": "34874953", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-14234"}, {"db": "URL", "key": "https://bmrb.io/data_library/summary/index.php?bmrbId=50915", "description": "https://bmrb.io/data_library/summary/index.php?bmrbId=50915"}], "notes": [], "created": "2021-12-12T07:11:59.861Z", "modified": "2021-12-12T07:14:03.149Z"}, {"entity": "publication", "iuid": "2ebebec3c32942c3bf6b1fd15d1623fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ebebec3c32942c3bf6b1fd15d1623fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ebebec3c32942c3bf6b1fd15d1623fa"}}, "title": "Impact of the COVID-19 pandemic on food production and animal health.", "authors": [{"family": "Rahimi", "given": "Parastoo", "initials": "P"}, {"family": "Islam", "given": "Md Saiful", "initials": "MS"}, {"family": "Duarte", "given": "Phelipe Magalh\u00e3es", "initials": "PM"}, {"family": "Tazerji", "given": "Sina Salajegheh", "initials": "SS"}, {"family": "Sobur", "given": "Md Abdus", "initials": "MA"}, {"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME"}, {"family": "Ashour", "given": "Hossam M", "initials": "HM"}, {"family": "Rahman", "given": "Md Tanvir", "initials": "MT"}], "type": "journal article", "published": "2021-12-06", "journal": {"title": "Trends Food Sci Technol", "issn": "0924-2244", "issn-l": null}, "abstract": "The new coronavirus, named the severe acute respiratory coronavirus syndrome 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 2019 (COVID-19). COVID-19 originated in China and spread to other countries and continents causing a variety of respiratory and non-respiratory symptoms that led to death in severe cases.\n\nIn this review, we discuss and analyze the impact of the COVID-19 pandemic on animal production systems and food products including meat, dairy, eggs, and processed food, in addition to assessing the pandemic's impact on animal health care systems, animal health care quality, animal welfare, food chain sustainability, and the global economy. We also provide effective recommendations to animal producers, veterinary healthcare professionals, workers in animal products industries, and governments to alleviate the effects of the pandemic on livestock farming and production systems.\n\nPort restrictions, border restrictions, curfews, and social distancing limitations led to reduced quality, productivity, and competitiveness of key productive sectors. The restrictions have hit the livestock sector hard by disrupting the animal feed supply chain, reducing animal farming services, limiting animal health services including delays in diagnosis and treatment of diseases, limiting access to markets and consumers, and reducing labor-force participation. The inhumane culling of animals jeopardized animal welfare. Egg smashing, milk dumping, and other animal product disruptions negatively impacted food production, consumption, and access to food originating from animals. In summary, COVID-triggered lockdowns and limitations on local and international trade have taken their toll on food production, animal production, and animal health and welfare. COVID-19 reverberations could exacerbate food insecurity, hunger, and global poverty. The effects could be massive on the most vulnerable populations and the poorest nations.", "doi": "10.1016/j.tifs.2021.12.003", "pmid": "34898853", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0924-2244(21)00660-9"}, {"db": "pmc", "key": "PMC8647343"}], "notes": [], "created": "2021-12-18T18:00:15.493Z", "modified": "2021-12-18T18:00:15.507Z"}, {"entity": "publication", "iuid": "6033244c29174016b12902edef9cdb24", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6033244c29174016b12902edef9cdb24.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6033244c29174016b12902edef9cdb24"}}, "title": "Convalescence plasma treatment of COVID-19: results from a prematurely terminated randomized controlled open-label study in Southern Sweden.", "authors": [{"family": "Holm", "given": "Karin", "initials": "K", "orcid": "0000-0002-8289-5949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7f590df41084ab28d7a1ac80b1b90e7.json"}}, {"family": "Lundgren", "given": "Maria N", "initials": "MN"}, {"family": "Kjeldsen-Kragh", "given": "Jens", "initials": "J"}, {"family": "Ljungquist", "given": "Oskar", "initials": "O"}, {"family": "B\u00f6ttiger", "given": "Blenda", "initials": "B"}, {"family": "Wik\u00e9n", "given": "Christian", "initials": "C"}, {"family": "\u00d6berg", "given": "Jonas", "initials": "J"}, {"family": "Fernstr\u00f6m", "given": "Nils", "initials": "N"}, {"family": "Rosendal", "given": "Ebba", "initials": "E"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "Wigren Bystr\u00f6m", "given": "Julia", "initials": "J"}, {"family": "Forsell", "given": "Mattias", "initials": "M"}, {"family": "Landin-Olsson", "given": "Mona", "initials": "M"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-12-04", "journal": {"title": "BMC Res Notes", "issn": "1756-0500", "volume": "14", "issue": "1", "pages": "440", "issn-l": null}, "abstract": "Convalescent plasma has been tried as therapy for various viral infections. Early observational studies of convalescent plasma treatment for hospitalized COVID-19 patients were promising, but randomized controlled studies were lacking at the time. The objective of this study was to investigate if convalescent plasma is beneficial to hospitalized patients with COVID-19.\n\nHospitalized patients with confirmed COVID-19 and an oxygen saturation below 94% were randomized 1:1 to receive convalescent plasma in addition to standard of care or standard of care only. The primary outcome was number of days of oxygen treatment to keep saturation above 93% within 28 days from inclusion. The study was prematurely terminated when thirty-one of 100 intended patients had been included. The median time of oxygen treatment among survivors was 11 days (IQR 6-15) for the convalescent plasma group and 7 days (IQR 5-9) for the standard of care group (p = 0.4, median difference -4). Two patients in the convalescent plasma group and three patients in the standard of care group died (p = 0.64, OR 0.49, 95% CI 0.08-2.79). Thus no significant differences were observed between the groups. Trial registration ClinicalTrials NCT04600440, retrospectively registered Oct 23, 2020.", "doi": "10.1186/s13104-021-05847-7", "pmid": "34863304", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13104-021-05847-7"}, {"db": "ClinicalTrials.gov", "key": "NCT04600440"}], "notes": [], "created": "2021-12-12T07:18:34.485Z", "modified": "2021-12-12T07:18:34.529Z"}, {"entity": "publication", "iuid": "e1e268c1633f431a94c89397bef8d775", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e1e268c1633f431a94c89397bef8d775.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e1e268c1633f431a94c89397bef8d775"}}, "title": "Longevity of anti-spike and anti-nucleocapsid antibodies after COVID-19 in solid organ transplant recipients compared to immunocompetent controls.", "authors": [{"family": "S\u00f8fteland", "given": "John Mackay", "initials": "JM", "orcid": "0000-0001-7993-5906", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ab059cbe643422e9da67347e1123200.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Liljeqvist", "given": "Jan-\u00c5ke", "initials": "J\u00c5"}, {"family": "Friman", "given": "Vanda", "initials": "V"}, {"family": "de Coursey", "given": "Emily", "initials": "E"}, {"family": "Karason", "given": "Kristjan", "initials": "K"}, {"family": "Ekelund", "given": "Jan", "initials": "J"}, {"family": "Felldin", "given": "Marie", "initials": "M"}, {"family": "Magnusson", "given": "Jesper", "initials": "J", "orcid": "0000-0002-5630-0155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d2adc110fad45618c8dc73505a3358b.json"}}, {"family": "Baid-Agrawal", "given": "Seema", "initials": "S"}, {"family": "Wallquist", "given": "Carin", "initials": "C"}, {"family": "Schult", "given": "Andreas", "initials": "A"}, {"family": "Jacobsson", "given": "Hanna", "initials": "H"}, {"family": "Bergdahl", "given": "Anders", "initials": "A"}, {"family": "Bemark", "given": "Mats", "initials": "M", "orcid": "0000-0001-7416-9819", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ae923943b6c4b4bb74ca1e14b426351.json"}}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Holm Gunnarsson", "given": "Inger", "initials": "I"}, {"family": "Stenstr\u00f6m", "given": "Jan", "initials": "J"}, {"family": "Leach", "given": "Susannah", "initials": "S", "orcid": "0000-0002-9614-2753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18d00be831d241dca238b3253d1b45f6.json"}}], "type": "journal article", "published": "2021-12-03", "journal": {"title": "Am J Transplant", "issn": "1600-6143", "issn-l": null}, "abstract": "Solid organ transplant recipients (SOTRs) are on lifelong immunosuppression, which may interfere with adaptive immunity to COVID-19. The data on dynamics and duration of antibody response in SOTRs are limited. This longitudinal study examined the longevity of both anti-spike (S)- and anti-nucleocapsid (N)-specific IgG-antibodies after COVID-19 in SOTRs compared to matched immunocompetent persons. SOTRs (n=65) were matched with controls (n=65) for COVID-19 disease severity, age, and sex in order of priority. Serum-IgG-antibodies against N- and S-antigens of SARS-CoV-2 were analyzed. At 1 and 9 months after COVID-19, anti-S-IgG detectability decreased from 91% to 82% in SOTRs versus 100% to 95% in controls, whereas the anti-N-IgG decreased from 63% to 29% in SOTRs versus 89% to 46% in controls. A matched paired analysis showed SOTRs having significantly lower levels of anti-N-IgG at all time points (1-month P=0.007, 3-months P<0.001, 6-months P=0.019 and 9-months P=0.021) but not anti-S-IgG at any time points. A mixed-model analysis confirmed these findings except for anti-S-IgG at one month (p=0.005) and identified severity score as the most important predictor of antibody response. SOTRs mount comparable S-specific, but not N-specific, antibody responses to SARS-CoV-2 infection compared to immunocompetent controls.", "doi": "10.1111/ajt.16909", "pmid": "34860447", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-13T06:15:42.289Z", "modified": "2021-12-13T06:16:04.675Z"}, {"entity": "publication", "iuid": "4d61723b79c4473b863d8be10bd85269", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4d61723b79c4473b863d8be10bd85269.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4d61723b79c4473b863d8be10bd85269"}}, "title": "Waning infant pertussis during COVID-19 pandemic.", "authors": [{"family": "Falkenstein-Hagander", "given": "Kathy", "initials": "K", "orcid": "0000-0001-8070-8591", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6bc0ee6ad2a241be887a0261ffcec215.json"}}, {"family": "Appelqvist", "given": "Emma", "initials": "E"}, {"family": "Cavefors", "given": "Ann-Sofie Frisk", "initials": "AF"}, {"family": "K\u00e4llberg", "given": "Henrik", "initials": "H"}, {"family": "Nilsson", "given": "Lennart Jan", "initials": "LJ"}, {"family": "Silfverdal", "given": "Sven-Arne", "initials": "SA", "orcid": "0000-0002-3606-3797", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82e58fba252946a091a386588684f781.json"}}, {"family": "Storsaeter", "given": "Jann", "initials": "J"}, {"family": "Aronsson", "given": "Bernice", "initials": "B"}], "type": "journal article", "published": "2021-12-02", "journal": {"title": "Arch Dis Child", "issn": "1468-2044", "issn-l": null}, "abstract": "Measures to reduce the spread of COVID-19 have been associated with reduction in other respiratory infections. Results of a national Swedish cohort study of infant pertussis during April 2020-September 2021 were compared with those during January 2014-March 2020. The number of pertussis cases decreased significantly during the COVID-19 pandemic, from an average of 21 infant cases per quarter of a year before the pandemic to an average of 1 case per quarter during the pandemic. Swedish strategies to mitigate the spread of COVID-19 seem to have had an impact on pertussis incidence in infants.", "doi": "10.1136/archdischild-2021-323055", "pmid": "34857511", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "archdischild-2021-323055"}], "notes": [], "created": "2021-12-18T18:07:33.933Z", "modified": "2021-12-18T18:07:34.039Z"}, {"entity": "publication", "iuid": "ced65694d052422c83e7f1562e1398ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ced65694d052422c83e7f1562e1398ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ced65694d052422c83e7f1562e1398ca"}}, "title": "Soluble Urokinase Plasminogen Activator Receptor (suPAR) Independently Predicts Severity and Length of Hospitalisation in Patients With COVID-19.", "authors": [{"family": "Enocsson", "given": "Helena", "initials": "H"}, {"family": "Idoff", "given": "Cornelia", "initials": "C"}, {"family": "Gustafsson", "given": "Annette", "initials": "A"}, {"family": "Govender", "given": "Melissa", "initials": "M"}, {"family": "Hopkins", "given": "Francis", "initials": "F"}, {"family": "Larsson", "given": "Marie", "initials": "M"}, {"family": "Nilsdotter-Augustinsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Sj\u00f6wall", "given": "Johanna", "initials": "J"}], "type": "journal article", "published": "2021-12-02", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "8", "pages": "791716", "issn-l": null}, "abstract": "Background: Efficient healthcare based on prognostic variables in hospitalised patients with COVID-19 could reduce the risk of complications and death. Recently, soluble urokinase Plasminogen Activator Receptor (suPAR) was shown to predict respiratory failure, kidney injury, and clinical outcome in patients with SARS-CoV-2 infection. The aim of this study was to investigate the value of suPAR as a prognostic tool, in comparison with other variables, regarding disease severity and length of hospital stay in patients with COVID-19. Patients and Methods: Individuals hospitalised with COVID-19 (40 males, 20 females; median age 57.5 years) with a median symptom duration of 10 days and matched, healthy controls (n = 30) were included. Admission levels of suPAR were measured in serum by enzyme-linked immunosorbent assay. Blood cell counts, C-reactive protein (CRP) levels, lactate dehydrogenase (LDH), plasma creatinine and estimated glomerular filtration rates were analysed and oxygen demand, level of care and length of hospitalisation recorded. Results: Patients had significantly higher suPAR levels compared to controls (P < 0.001). Levels were higher in severely/critically (median 6.6 ng/mL) compared with moderately ill patients (median 5.0 ng/mL; P = 0.002). In addition, suPAR levels correlated with length of hospitalisation (rho = 0.35; P = 0.006). Besides suPAR, LDH, CRP, neutrophil count, neutrophil-to-monocyte and neutrophil-to-lymphocyte ratio, body mass index and chronic renal failure were discriminators of COVID-19 severity and/or predictors of length of hospitalisation. Conclusion: Admission levels of suPAR were higher in patients who developed severe/critical COVID-19 and associated with length of hospital stay. In addition, we showed that suPAR functioned as an independent predictor of COVID-19 disease severity.", "doi": "10.3389/fmed.2021.791716", "pmid": "34926532", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8674575"}], "notes": [], "created": "2022-01-03T15:22:31.284Z", "modified": "2022-01-03T15:22:59.724Z"}, {"entity": "publication", "iuid": "d248640d9017480f810e715041594cc3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d248640d9017480f810e715041594cc3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d248640d9017480f810e715041594cc3"}}, "title": "Randomised clinical trials in critical care: past, present and future.", "authors": [{"family": "Granholm", "given": "Anders", "initials": "A", "orcid": "0000-0001-5799-7655", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d058ecb91d4c482abbee511b044ddf75.json"}}, {"family": "Alhazzani", "given": "Waleed", "initials": "W"}, {"family": "Derde", "given": "Lennie P G", "initials": "LPG"}, {"family": "Angus", "given": "Derek C", "initials": "DC"}, {"family": "Zampieri", "given": "Fernando G", "initials": "FG"}, {"family": "Hammond", "given": "Naomi E", "initials": "NE"}, {"family": "Sweeney", "given": "Rob Mac", "initials": "RM"}, {"family": "Myatra", "given": "Sheila N", "initials": "SN"}, {"family": "Azoulay", "given": "Elie", "initials": "E"}, {"family": "Rowan", "given": "Kathryn", "initials": "K"}, {"family": "Young", "given": "Paul J", "initials": "PJ"}, {"family": "Perner", "given": "Anders", "initials": "A"}, {"family": "M\u00f8ller", "given": "Morten Hylander", "initials": "MH"}], "type": "journal article", "published": "2021-12-02", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "issn-l": "0342-4642"}, "abstract": "Randomised clinical trials (RCTs) are the gold standard for providing unbiased evidence of intervention effects. Here, we provide an overview of the history of RCTs and discuss the major challenges and limitations of current critical care RCTs, including overly optimistic effect sizes; unnuanced conclusions based on dichotomization of results; limited focus on patient-centred outcomes other than mortality; lack of flexibility and ability to adapt, increasing the risk of inconclusive results and limiting knowledge gains before trial completion; and inefficiency due to lack of re-use of trial infrastructure. We discuss recent developments in critical care RCTs and novel methods that may provide solutions to some of these challenges, including a research programme approach (consecutive, complementary studies of multiple types rather than individual, independent studies), and novel design and analysis methods. These include standardization of trial protocols; alternative outcome choices and use of core outcome sets; increased acceptance of uncertainty, probabilistic interpretations and use of Bayesian statistics; novel approaches to assessing heterogeneity of treatment effects; adaptation and platform trials; and increased integration between clinical trials and clinical practice. We outline the advantages and discuss the potential methodological and practical disadvantages with these approaches. With this review, we aim to inform clinicians and researchers about conventional and novel RCTs, including the rationale for choosing one or the other methodological approach based on a thorough discussion of pros and cons. Importantly, the most central feature remains the randomisation, which provides unparalleled restriction of confounding compared to non-randomised designs by reducing confounding to chance.", "doi": "10.1007/s00134-021-06587-9", "pmid": "34853905", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-021-06587-9"}, {"db": "pmc", "key": "PMC8636283"}], "notes": [], "created": "2021-12-18T18:08:36.279Z", "modified": "2021-12-18T18:08:36.311Z"}, {"entity": "publication", "iuid": "4b5d4b1020ba4be3b34456be993e921a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b5d4b1020ba4be3b34456be993e921a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b5d4b1020ba4be3b34456be993e921a"}}, "title": "Lifestyle and mental health 1 year into COVID-19.", "authors": [{"family": "Barbieri", "given": "Paolo Nicola", "initials": "PN"}, {"family": "Giuntella", "given": "Osea", "initials": "O"}, {"family": "Saccardo", "given": "Silvia", "initials": "S"}, {"family": "Sadoff", "given": "Sally", "initials": "S"}], "type": "journal article", "published": "2021-12-02", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "23349", "issn-l": "2045-2322"}, "abstract": "In previous work, Giuntella et al. (Proc Natl Acad Sci 118:e2016632118, 2021), we documented large disruptions to physical activity, sleep, time use and mental health among young adults at the onset of the COVID-19 pandemic in Spring 2020. This study explores the trends 1 year into COVID-19, as vaccines began to roll out, COVID-19 deaths declined, and social distancing measures eased in the United States. We combine biometric and survey data from multiple cohorts of college students spanning Spring 2019 through Spring 2021 (N = 1179). Our results show persistent impacts of the pandemic on physical activity and mental health. One year into the pandemic, daily steps averaged about 6300 per day compared to about 9800 per day prior to the pandemic, a 35% decline. Almost half of participants were at risk of clinical depression compared to a little over one-third prior to the pandemic, a 36% increase. The impacts on screen time, social interactions and sleep duration at the onset of COVID-19 largely dissipated over the course of the pandemic, though screen time remained significantly higher than pre-pandemic levels. In contrast to the sharp changes in lifestyle and mental health documented as the pandemic emerged in March 2020, we do not find evidence of behavioral changes or improvements in mental well-being over the course of Spring 2021 as the pandemic eased.", "doi": "10.1038/s41598-021-02702-4", "pmid": "34857806", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-02702-4"}, {"db": "pmc", "key": "PMC8640003"}], "notes": [], "created": "2021-12-18T18:07:18.938Z", "modified": "2021-12-18T18:07:18.950Z"}, {"entity": "publication", "iuid": "6bda32f2b9534efea4411fa34bd79b94", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6bda32f2b9534efea4411fa34bd79b94.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6bda32f2b9534efea4411fa34bd79b94"}}, "title": "Secondary effects of the COVID-19 pandemic on surgical management of hepatopancreatobiliary malignancies in the Nordic capitals.", "authors": [{"family": "Holmberg", "given": "Marcus", "initials": "M", "orcid": "0000-0002-7217-4240", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76b4c749d77a400d83c23c415c1162de.json"}}, {"family": "Koppatz", "given": "Hanna", "initials": "H"}, {"family": "Jansson", "given": "Anders", "initials": "A"}, {"family": "Hillings\u00f8", "given": "Jens Georg", "initials": "JG", "orcid": "0000-0002-2381-7836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb166927097b40fe82cacd2d2f4793bf.json"}}, {"family": "Noergaard Larsen", "given": "Peter", "initials": "P"}, {"family": "Lassen", "given": "Kristoffer", "initials": "K", "orcid": "0000-0003-0039-6554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/401fe4d0146a494db0e6cf59b7be9d54.json"}}, {"family": "Sallinen", "given": "Ville", "initials": "V", "orcid": "0000-0001-5394-4169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/85f283d1d6554ad5a8475ceb27e195bc.json"}}, {"family": "Yaqub", "given": "Sheraz", "initials": "S", "orcid": "0000-0002-5696-2319", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4327b96c3bc4b9fbe30dd894b62c559.json"}}, {"family": "Sparrelid", "given": "Ernesto", "initials": "E"}], "type": "journal article", "published": "2021-12-01", "journal": {"title": "Br J Surg", "issn": "1365-2168", "issn-l": null}, "abstract": null, "doi": "10.1093/bjs/znab405", "pmid": "34850850", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6447105"}], "notes": [], "created": "2021-12-18T18:09:38.851Z", "modified": "2021-12-18T18:09:39.053Z"}, {"entity": "publication", "iuid": "cfb3f01277ce402fbb487d4eb3edf6f5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfb3f01277ce402fbb487d4eb3edf6f5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfb3f01277ce402fbb487d4eb3edf6f5"}}, "title": "Rituximab Infusion Timing, Cumulative Dose, and Hospitalization for COVID-19 in Persons With Multiple Sclerosis in Sweden.", "authors": [{"family": "McKay", "given": "Kyla A", "initials": "KA"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Englund", "given": "Simon", "initials": "S"}, {"family": "He", "given": "Anna", "initials": "A"}, {"family": "Langer-Gould", "given": "Annette", "initials": "A"}, {"family": "Hillert", "given": "Jan", "initials": "J"}, {"family": "Frisell", "given": "Thomas", "initials": "T"}], "type": "clinical trial", "published": "2021-12-01", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "volume": "4", "issue": "12", "pages": "e2136697", "issn-l": null}, "abstract": null, "doi": "10.1001/jamanetworkopen.2021.36697", "pmid": "34851401", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "2786701"}, {"db": "pmc", "key": "PMC8637249"}], "notes": [], "created": "2021-12-18T18:09:05.760Z", "modified": "2021-12-18T18:09:05.773Z"}, {"entity": "publication", "iuid": "249f16ed4f2846019d1404d1d2f0c6f5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/249f16ed4f2846019d1404d1d2f0c6f5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/249f16ed4f2846019d1404d1d2f0c6f5"}}, "title": "Occupational exposure and risk of transmission of SARS-CoV2 among European anaesthetists.", "authors": [{"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Longrois", "given": "Dan", "initials": "D"}, {"family": "Bruder", "given": "Nicolas", "initials": "N"}], "type": "journal article", "published": "2021-12-01", "journal": {"title": "Eur J Anaesthesiol", "issn": "1365-2346", "volume": "38", "issue": "12", "pages": "1272-1273", "issn-l": null}, "abstract": null, "doi": "10.1097/EJA.0000000000001607", "pmid": "34735396", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "00003643-202112000-00008"}], "notes": [], "created": "2021-11-26T15:40:44.860Z", "modified": "2021-11-26T15:40:44.874Z"}, {"entity": "publication", "iuid": "1022991309d94307b1cdce7fed18bade", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1022991309d94307b1cdce7fed18bade.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1022991309d94307b1cdce7fed18bade"}}, "title": "Impact of the COVID-19 Pandemic on the General Mental Health in Sweden: No Observed Changes in the Dispensed Amount of Common Psychotropic Medications in the Region of Scania.", "authors": [{"family": "Wolfschlag", "given": "Mirjam", "initials": "M"}, {"family": "Grudet", "given": "C\u00e9cile", "initials": "C"}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-12-01", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "731297", "issn-l": "1664-0640"}, "abstract": "Some first investigations have focused on the consequences of the COVID-19 pandemic for the general mental health after its outbreak in 2020. According to multiple self-reporting surveys, symptoms of stress, anxiety, and depression have risen worldwide. Even some studies based on health care records start to be published, providing more objective and statistically reliable results. Additionally, concerns have been raised, to what extend the access to mental health care has been compromised by the COVID-19 outbreak. The aim of this study was to detect changes in prescription trends of common psychotropic medications in the Swedish region of Scania. The monthly dispensed amounts of selected pharmaceuticals were compared from January 2018 until January 2021, regarding the prescription trends before and after the outbreak of COVID-19. Using an interrupted time series analysis for each medication, no general trend changes were observed. On the one hand, a possible deterioration of the general mental health could not be confirmed by these results. On the other hand, the access to mental health care did not seem to be impaired by the pandemic. When interpreting findings related to the COVID-19 pandemic, regional differences and country-specific approaches for coping with the pandemic should be considered. The Swedish population, for instance, never experienced a full \"lock-down\" and within Sweden the time point of the outbreak waves differed regionally. In general, the effects of the COVID-19 outbreak on mental health are still unclear and need to be investigated further in an international comparison.", "doi": "10.3389/fpsyt.2021.731297", "pmid": "34925084", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8671297"}], "notes": [], "created": "2022-01-03T15:22:11.541Z", "modified": "2022-01-03T15:22:11.553Z"}, {"entity": "publication", "iuid": "975ae46bee0a4573a8a3cb07c24dbab1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/975ae46bee0a4573a8a3cb07c24dbab1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/975ae46bee0a4573a8a3cb07c24dbab1"}}, "title": "Immunogenicity and tolerability of COVID-19 vaccination in peritoneal dialysis patients-A prospective observational cohort study.", "authors": [{"family": "Haase", "given": "Michael", "initials": "M", "orcid": "0000-0001-8212-7416", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3d5795641ee4ff0ab46f79603ba5e73.json"}}, {"family": "Lesny", "given": "Paul", "initials": "P"}, {"family": "Haase-Fielitz", "given": "Anja", "initials": "A"}, {"family": "Anderson", "given": "Mark", "initials": "M"}, {"family": "Cloherty", "given": "Gavin", "initials": "G"}, {"family": "Stec", "given": "Michael", "initials": "M"}, {"family": "Lucas", "given": "Carlos", "initials": "C"}, {"family": "Santos-Araujo", "given": "Carla", "initials": "C"}, {"family": "Haarhaus", "given": "Mathias", "initials": "M"}, {"family": "Macario", "given": "Fernando", "initials": "F"}], "type": "journal article", "published": "2021-12-01", "journal": {"title": "Semin Dial", "issn": "1525-139X", "issn-l": null}, "abstract": "In peritoneal dialysis (PD) patients, information on the immunogenicity and tolerability of SARS-CoV-2 vaccination is still scarce. We compared the immunogenicity and tolerability of SARS-CoV-2 vaccination of PD patients with that of medical personnel.\n\nIn a prospective observational cohort study, PD patients and immunocompetent medical personnel were evaluated for SARS-CoV-2 spike-IgG- and Nucleocapsid-IgG-antibody-levels before, 2 weeks after the first, and 6 weeks after the second SARS-CoV-2 vaccination and vaccine tolerability after the first and second vaccination.\n\nIn COVID-19-na\u00efve PD patients (N = 19), lower SARS-CoV-2-spike-IgG-levels were found compared with COVID-19-na\u00efve medical personnel (N = 24) 6 weeks after second vaccination (median 1438 AU/ml [25th-75th percentile 775-5261] versus 4577 [1529-9871]; p = 0.045). This finding resulted in a lower rate of strong vaccine response (spike-IgG \u2265 1000 AU/ml) of COVID-19-na\u00efve PD patients compared with medical personnel (58% versus 92%; p = 0.013), but not for seroconversion rate (spike-IgG \u2265 50 AU/ml: 100% vs. 100%; p > 0.99). After first vaccination, COVID-na\u00efve PD patients presented with significantly fewer side effects than medical personnel (number of any side effect: 1 [1-2] vs. 4 [1-7]; p = 0.015). A similar pattern with slightly decreased frequencies of side effects was observed for tolerability of second SARS-CoV-2 vaccination in PD patients and medical personnel (number of any side effects: 1 [1-1] vs. 2 [1-5]; p = 0.006).\n\nSARS-CoV-2 vaccination in COVID-19-na\u00efve PD patients appeared to induce a very high rate of seroconversion but a substantially lower rate of patients with a strong response compared with medical personnel. Vaccination appeared to be safe in the PD patients studied.", "doi": "10.1111/sdi.13043", "pmid": "34854131", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T18:08:07.445Z", "modified": "2021-12-18T18:08:07.524Z"}, {"entity": "publication", "iuid": "a1d55643d2544ade95def5ade92d4e63", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a1d55643d2544ade95def5ade92d4e63.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a1d55643d2544ade95def5ade92d4e63"}}, "title": "First comparison of conventional activated sludge versus root-zone treatment for SARS-CoV-2 RNA removal from wastewaters: Statistical and temporal significance.", "authors": [{"family": "Kumar", "given": "Manish", "initials": "M"}, {"family": "Kuroda", "given": "Keisuke", "initials": "K"}, {"family": "Joshi", "given": "Madhvi", "initials": "M"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Barcelo", "given": "Damia", "initials": "D"}], "type": "journal article", "published": "2021-12-01", "journal": {"title": "Chem Eng J", "issn": "1385-8947", "volume": "425", "pages": "130635", "issn-l": null}, "abstract": "In the initial pandemic phase, effluents from wastewater treatment facilities were reported mostly free from Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) RNA, and thus conventional wastewater treatments were generally considered effective. However, there is a lack of first-hand data on i) comparative efficacy of various treatment processes for SARS-CoV-2 RNA removal; and ii) temporal variations in the removal efficacy of a given treatment process in the backdrop of active COVID-19 cases. This work provides a comparative account of the removal efficacy of conventional activated sludge (CAS) and root zone treatments (RZT) based on weekly wastewater surveillance data, consisting of forty-four samples, during a two-month period. The average genome concentration was higher in the inlets of CAS-based wastewater treatment plant (WWTP) in the Sargasan ward (1.25 \u00d7 103 copies/ L), than that of RZT-based WWTP (7.07 \u00d7 102 copies/ L) in an academic institution campus of Gandhinagar, Gujarat, India. ORF 1ab and S genes appeared to be more sensitive to treatment i.e., significantly reduced (p < 0.05) than N genes (p > 0.05). CAS treatment exhibited better RNA removal efficacy (p = 0.014) than RZT (p = 0.032). Multivariate analyses suggested that the effective genome concentration should be calculated based on the presence/absence of multiple genes. The present study stresses that treated effluents are not always free from SARS-CoV-2 RNA, and the removal efficacy of a given WWTP is prone to exhibit temporal variability owing to variations in active COVID-19 cases in the vicinity and genetic material accumulation over the time. Disinfection seems less effective than the adsorption and coagulation processes for SARS-CoV-2 removal. Results stress the need for further research on mechanistic insight on SARS-CoV-2 removal through various treatment processes taking solid-liquid partitioning into account.", "doi": "10.1016/j.cej.2021.130635", "pmid": "34149304", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S1385-8947(21)02221-X"}, {"db": "pmc", "key": "PMC8200644"}], "notes": [], "created": "2021-06-28T18:24:38.522Z", "modified": "2021-06-28T18:25:01.598Z"}, {"entity": "publication", "iuid": "43d35f6703f84ec795db14f09a692c1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/43d35f6703f84ec795db14f09a692c1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/43d35f6703f84ec795db14f09a692c1d"}}, "title": "Emergence of new SARS-CoV-2 Variant of Concern Omicron (B.1.1.529) - highlights Africa's research capabilities, but exposes major knowledge gaps, inequities of vaccine distribution, inadequacies in global COVID-19 response and control efforts.", "authors": [{"family": "Petersen", "given": "Eskild", "initials": "E"}, {"family": "Ntoumi", "given": "Francine", "initials": "F"}, {"family": "Hui", "given": "David S", "initials": "DS"}, {"family": "Abubakar", "given": "Aisha", "initials": "A"}, {"family": "Kramer", "given": "Laura D", "initials": "LD"}, {"family": "Obiero", "given": "Christina", "initials": "C"}, {"family": "Tambyah", "given": "Paul Anantharajah", "initials": "PA"}, {"family": "Blumberg", "given": "Lucille", "initials": "L"}, {"family": "Yapi", "given": "Richard", "initials": "R"}, {"family": "Al-Abri", "given": "Seif", "initials": "S"}, {"family": "Pinto", "given": "Tatiana de Castro Abreu", "initials": "TCA"}, {"family": "Yeboah-Manu", "given": "Dorothy", "initials": "D"}, {"family": "Haider", "given": "Najmul", "initials": "N"}, {"family": "Asogun", "given": "Danny", "initials": "D"}, {"family": "Velavan", "given": "Thirumalaisamy P", "initials": "TP"}, {"family": "Kapata", "given": "Nathan", "initials": "N"}, {"family": "Bates", "given": "Matthew", "initials": "M"}, {"family": "Ansumana", "given": "Rashid", "initials": "R"}, {"family": "Montaldo", "given": "Chiara", "initials": "C"}, {"family": "Mucheleng'anga", "given": "Luchenga", "initials": "L"}, {"family": "Tembo", "given": "John", "initials": "J"}, {"family": "Mwaba", "given": "Peter", "initials": "P"}, {"family": "Himwaze", "given": "Cordelia M", "initials": "CM"}, {"family": "Hamid", "given": "Muzamil Mahdi Abdel", "initials": "MMA"}, {"family": "Mfinanga", "given": "Sayoki", "initials": "S"}, {"family": "Mboera", "given": "Leonard", "initials": "L"}, {"family": "Raj", "given": "Tajudeen", "initials": "T"}, {"family": "Aklillu", "given": "Eleni", "initials": "E"}, {"family": "Veas", "given": "Francisco", "initials": "F"}, {"family": "Edwards", "given": "Sarah", "initials": "S"}, {"family": "Kaleebu", "given": "Pontiano", "initials": "P"}, {"family": "McHugh", "given": "Timothy D", "initials": "TD"}, {"family": "Chakaya", "given": "Jeremiah", "initials": "J"}, {"family": "Nyirenda", "given": "Thomas", "initials": "T"}, {"family": "Bockarie", "given": "Moses", "initials": "M"}, {"family": "Nyasulu", "given": "Peter S", "initials": "PS"}, {"family": "Wejse", "given": "Christian", "initials": "C"}, {"family": "Muyembe-Tamfum", "given": "Jean-Jacques", "initials": "JJ"}, {"family": "Azhar", "given": "Esam I", "initials": "EI"}, {"family": "Maeurer", "given": "Markus", "initials": "M"}, {"family": "Nachega", "given": "Jean B", "initials": "JB"}, {"family": "Kock", "given": "Richard", "initials": "R"}, {"family": "Ippolito", "given": "Giuseppe", "initials": "G"}, {"family": "Zumla", "given": "Alimuddin", "initials": "A"}], "type": "editorial", "published": "2021-12-01", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712"}, "abstract": null, "doi": "10.1016/j.ijid.2021.11.040", "pmid": "34863925", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)00888-2"}], "notes": [], "created": "2021-12-12T07:17:49.046Z", "modified": "2021-12-12T07:17:49.060Z"}, {"entity": "publication", "iuid": "d8a5430224524a14a61f7f510d8ee762", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d8a5430224524a14a61f7f510d8ee762.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d8a5430224524a14a61f7f510d8ee762"}}, "title": "Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality", "authors": [{"family": "Nakanishi", "given": "Tomoko", "initials": "T", "orcid": "0000-0001-9510-5646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd273e50091d44c3b3e8d1473ce89b0a.json"}}, {"family": "Pigazzini", "given": "Sara", "initials": "S", "orcid": "0000-0002-0641-9393", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b0633eaa95524db89712be8570a96731.json"}}, {"family": "Degenhardt", "given": "Frauke", "initials": "F", "orcid": "0000-0001-7516-3179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab8dc6a0eb504f41a89c140d68b87b6a.json"}}, {"family": "Cordioli", "given": "Mattia", "initials": "M", "orcid": "0000-0002-4872-0520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/973dc15953ef42ddb7844615904f887d.json"}}, {"family": "Butler-Laporte", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-5388-0396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/529dc69151d3463e8480b975d70fa759.json"}}, {"family": "Maya-Miles", "given": "Douglas", "initials": "D", "orcid": "0000-0002-0669-6526", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1ef23ddbaa8475192c07bd33bcbf435.json"}}, {"family": "Bujanda", "given": "Luis", "initials": "L", "orcid": "0000-0002-4353-9968", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de96cde07e1d49d2a2001537b317111a.json"}}, {"family": "Bouysran", "given": "Youssef", "initials": "Y"}, {"family": "Niemi", "given": "Mari E K", "initials": "MEK", "orcid": "0000-0003-0696-6175", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87d6c30c910c4c989095e2f026194490.json"}}, {"family": "Palom", "given": "Adriana", "initials": "A", "orcid": "0000-0002-0130-1302", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a89c9483db484981ad3f218056b35c9a.json"}}, {"family": "Ellinghaus", "given": "David", "initials": "D", "orcid": "0000-0002-4332-6110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a6cdcc3819e45a08ab598ae7afbfb94.json"}}, {"family": "Khan", "given": "Atlas", "initials": "A"}, {"family": "Mart\u00ednez-Bueno", "given": "Manuel", "initials": "M"}, {"family": "Rolker", "given": "Selina", "initials": "S"}, {"family": "Amitrano", "given": "Sara", "initials": "S"}, {"family": "Roade Tato", "given": "Luisa", "initials": "L"}, {"family": "Fava", "given": "Francesca", "initials": "F"}, {"family": "Spinner", "given": "Christoph D", "initials": "CD", "orcid": "0000-0002-3875-5367", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c506eb763b34155bbc6187f4ccb5f62.json"}}, {"family": "Prati", "given": "Daniele", "initials": "D", "orcid": "0000-0002-2281-7498", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/050d5b4534914e2cb3c9ec64bc5fedaa.json"}}, {"family": "Bernardo", "given": "David", "initials": "D", "orcid": "0000-0002-2843-6696", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5cdb7b8db1f4cb18eda0884c430704f.json"}}, {"family": "Garcia", "given": "Federico", "initials": "F"}, {"family": "Darcis", "given": "Gilles", "initials": "G"}, {"family": "Fern\u00e1ndez-Cadenas", "given": "Israel", "initials": "I"}, {"family": "Holter", "given": "Jan Cato", "initials": "JC", "orcid": "0000-0003-1618-5022", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7b6512c252a422badaaa120ee2aa700.json"}}, {"family": "Banales", "given": "Jesus M", "initials": "JM"}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Kiryluk", "given": "Krzysztof", "initials": "K", "orcid": "0000-0002-5047-6715", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d1362394dec4a7e934fd6c79ad94df3.json"}}, {"family": "Duga", "given": "Stefano", "initials": "S", "orcid": "0000-0003-3457-1410", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f14e5b5dec36415fa1627265d55f8754.json"}}, {"family": "Asselta", "given": "Rosanna", "initials": "R"}, {"family": "Pereira", "given": "Alexandre C", "initials": "AC", "orcid": "0000-0002-7782-5540", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bb55d803b824076b67a01d2790d2986.json"}}, {"family": "Romero-G\u00f3mez", "given": "Manuel", "initials": "M", "orcid": "0000-0001-8494-8947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64e5a4afafa14d5eaeb7957c0061622a.json"}}, {"family": "Nafr\u00eda-Jim\u00e9nez", "given": "Beatriz", "initials": "B", "orcid": "0000-0002-4698-5680", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/782c0cfe62d94457a45fa94098bf3aab.json"}}, {"family": "Hov", "given": "Johannes R", "initials": "JR", "orcid": "0000-0002-5900-8096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83964c456ae5424f8138304aa9dbc26b.json"}}, {"family": "Migeotte", "given": "Isabelle", "initials": "I"}, {"family": "Renieri", "given": "Alessandra", "initials": "A"}, {"family": "Planas", "given": "Anna M", "initials": "AM", "orcid": "0000-0002-6147-1880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ecaec25d7eeb43bca29edd1ed56cecc7.json"}}, {"family": "Ludwig", "given": "Kerstin U", "initials": "KU", "orcid": "0000-0002-8541-2519", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02922a1f71c64a8e9dc6aa1c29a20270.json"}}, {"family": "Buti", "given": "Maria", "initials": "M", "orcid": "0000-0002-0732-3078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4207dfbc876c49a58e210b056d3b0191.json"}}, {"family": "Rahmouni", "given": "Souad", "initials": "S", "orcid": "0000-0003-0956-0242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4dac12a55b94325b711fd13394a4285.json"}}, {"family": "Alarc\u00f3n-Riquelme", "given": "Marta E", "initials": "ME", "orcid": "0000-0002-7632-4154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f74dd701d8442c992fe172be2d2c5bf.json"}}, {"family": "Schulte", "given": "Eva C", "initials": "EC", "orcid": "0000-0003-3105-5672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b02ec0962cdc4e15853c4a3aeba4992d.json"}}, {"family": "Franke", "given": "Andre", "initials": "A"}, {"family": "Karlsen", "given": "Tom H", "initials": "TH"}, {"family": "Valenti", "given": "Luca", "initials": "L", "orcid": "0000-0001-8909-0345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/964a9d9544f64f2080930bcaec06d1cf.json"}}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ee1510080704cf6a2a6972deb94123f.json"}}, {"family": "Richards", "given": "J Brent", "initials": "JB", "orcid": "0000-0002-3746-9086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8994152547ee4765b1653b834c52a21a.json"}}, {"family": "Ganna", "given": "Andrea", "initials": "A"}], "type": "journal-article", "published": "2021-12-01", "journal": {"title": "J Clin Invest", "issn": "1558-8238", "issn-l": null, "volume": "131", "issue": "23", "pages": null}, "abstract": "Abstract\r\nBackground There is considerable variability in COVID-19 outcomes amongst younger adults\u2014and some of this variation may be due to genetic predisposition. We characterized the clinical implications of the major genetic risk factor for COVID-19 severity, and its age-dependent effect, using individual-level data in a large international multi-centre consortium.\r\n\r\nMethod The major common COVID-19 genetic risk factor is a chromosome 3 locus, tagged by the marker rs10490770. We combined individual level data for 13,424 COVID-19 positive patients (N=6,689 hospitalized) from 17 cohorts in nine countries to assess the association of this genetic marker with mortality, COVID-19-related complications and laboratory values. We next examined if the magnitude of these associations varied by age and were independent from known clinical COVID-19 risk factors.\r\n\r\nFindings We found that rs10490770 risk allele carriers experienced an increased risk of all-cause mortality (hazard ratio [HR] 1\u00b74, 95% confidence interval [CI] 1\u00b72\u20131\u00b76) and COVID-19 related mortality (HR 1\u00b75, 95%CI 1\u00b73\u20131\u00b78). Risk allele carriers had increased odds of several COVID-19 complications: severe respiratory failure (odds ratio [OR] 2\u00b70, 95%CI 1\u00b76-2\u00b76), venous thromboembolism (OR 1\u00b77, 95%CI 1\u00b72-2\u00b74), and hepatic injury (OR 1\u00b76, 95%CI 1\u00b72-2\u00b70). Risk allele carriers \u2264 60 years had higher odds of death or severe respiratory failure (OR 2\u00b76, 95%CI 1\u00b78-3\u00b79) compared to those > 60 years OR 1\u00b75 (95%CI 1\u00b73-1\u00b79, interaction p-value=0\u00b704). Amongst individuals \u2264 60 years who died or experienced severe respiratory COVID-19 outcome, we found that 31\u00b78% (95%CI 27\u00b76-36\u00b72) were risk variant carriers, compared to 13\u00b79% (95%CI 12\u00b76-15\u00b72%) of those not experiencing these outcomes. Prediction of death or severe respiratory failure among those \u2264 60 years improved when including the risk allele (AUC 0\u00b782 vs 0\u00b784, p=0\u00b7016) and the prediction ability of rs10490770 risk allele was similar to, or better than, most established clinical risk factors.\r\n\r\nInterpretation The major common COVID-19 risk locus on chromosome 3 is associated with increased risks of morbidity and mortality\u2014and these are more pronounced amongst individuals \u2264 60 years. The effect on COVID-19 severity was similar to, or larger than most established risk factors, suggesting potential implications for clinical risk management.", "doi": "10.1172/jci152386", "pmid": "34597274", "labels": {"Category: Genomics & transcriptomics": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: VR": null, "Type: Journal article": null}, "xrefs": [{"db": "URL", "key": "https://www.medrxiv.org/node/316122.external-links.html", "description": "Procedures for accessing data can be found here (data cannot be publicly shared)"}], "notes": [], "created": "2021-03-15T17:30:18.883Z", "modified": "2022-02-14T16:22:27.472Z"}, {"entity": "publication", "iuid": "900640627af44768b241c6508c8be114", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/900640627af44768b241c6508c8be114.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/900640627af44768b241c6508c8be114"}}, "title": "ACE2 Peptide Fragment Interaction with Different S1 Protein Sites.", "authors": [{"family": "Kuznetsov", "given": "Aleksei", "initials": "A"}, {"family": "Arukuusk", "given": "Piret", "initials": "P"}, {"family": "H\u00e4rk", "given": "Heleri", "initials": "H"}, {"family": "Juronen", "given": "Erkki", "initials": "E"}, {"family": "Ustav", "given": "Mart", "initials": "M"}, {"family": "Langel", "given": "\u00dclo", "initials": "\u00dc"}, {"family": "J\u00e4rv", "given": "Jaak", "initials": "J", "orcid": "0000-0003-1042-2701", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/420b8713e79744df8f4f8c4b83c120d1.json"}}], "type": "journal article", "published": "2021-12-01", "journal": {"title": "Int J Pept Res Ther", "issn": "1573-3149", "volume": "28", "issue": "1", "pages": "7", "issn-l": null}, "abstract": "We study the effect of the peptide QAKTFLDKFNHEAEDLFYQ on the kinetics of the SARS-CoV-2 spike protein S1 binding to angiotensin-converting enzyme 2 (ACE2), with the aim to characterize the interaction mechanism of the SARS-CoV2 virus with its host cell. This peptide corresponds to the sequence 24-42 of the ACE2 \u03b11 domain, which marks the binding site for the S1 protein. The kinetics of S1-ACE2 complex formation was measured in the presence of various concentrations of the peptide using bio-layer interferometry. Formation of the S1-ACE2 complex was inhibited by the peptide in cases where it was preincubated with S1 protein before the binding experiment. The kinetic analysis of S1-ACE2 complex dissociation revealed that preincubation stabilized this complex, and this effect was dependent on the peptide concentration as well as the preincubation time. The results point to the formation of the ternary complex of S1 with ACE2 and the peptide. This is possible in the presence of another binding site for the S1 protein beside the receptor-binding domain for ACE2, which binds the peptide QAKTFLDKFNHEAEDLFYQ. Therefore, we conducted computational mapping of the S1 protein surface, revealing two additional binding sites located at some distance from the main receptor-binding domain on S1. We suggest the possibility to predict and test the short protein derived peptides for development of novel strategies in inhibiting virus infections.\n\nThe online version contains supplementary material available at 10.1007/s10989-021-10324-7.", "doi": "10.1007/s10989-021-10324-7", "pmid": "34867130", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10324"}, {"db": "pmc", "key": "PMC8634746"}], "notes": [], "created": "2021-12-12T07:06:25.059Z", "modified": "2021-12-12T07:06:25.142Z"}, {"entity": "publication", "iuid": "1837bfc6926f48cfa24e4dedbed1098a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1837bfc6926f48cfa24e4dedbed1098a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1837bfc6926f48cfa24e4dedbed1098a"}}, "title": "To be or not to be vaccinated against COVID-19 - The adolescents' perspective - A mixed-methods study in Sweden.", "authors": [{"family": "Nilsson", "given": "S", "initials": "S"}, {"family": "Mattson", "given": "J", "initials": "J"}, {"family": "Berghammer", "given": "M", "initials": "M"}, {"family": "Brorsson", "given": "A-L", "initials": "AL"}, {"family": "Forsner", "given": "M", "initials": "M"}, {"family": "Jenholt Nolbris", "given": "M", "initials": "M"}, {"family": "Kull", "given": "I", "initials": "I"}, {"family": "Lindholm Olinder", "given": "A", "initials": "A"}, {"family": "Ragnarsson", "given": "S", "initials": "S"}, {"family": "Rullander", "given": "A-C", "initials": "AC"}, {"family": "Rydstr\u00f6m", "given": "L-L", "initials": "LL"}, {"family": "Andr\u00e9ia Garcia de Avila", "given": "M", "initials": "M"}, {"family": "Olaya-Contreras", "given": "P", "initials": "P"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Vaccine X", "issn": "2590-1362", "issn-l": null, "volume": "9", "issue": null, "pages": "100117"}, "abstract": "Vaccination of the population seems to be an important strategy in halting the COVID-19 pandemic in both local and global society. The aim of this study was to explore Swedish adolescents' willingness to be vaccinated against COVID-19 and its association with sociodemographic and other possible factors. A survey was distributed in Sweden between 7 July and 8 November 2020. The main qualitative question concerned adolescents' thoughts on vaccination against COVID-19 and evaluated whether the adolescents would like to be vaccinated when a COVID-19 vaccine is made available. In total, 702 adolescents aged between 15 and 19 responded to the questionnaire. A convergent parallel mixed-methods design was used. The results showed that nearly one in three adolescents had not decided if they wanted to get a COVID-19 vaccine, i.e. 30.5%: n = 214. Of the participants 54.3% (n = 381) were willing to be vaccinated. Girls had higher levels of anxiety about the vaccine compared to boys. In addition, high levels of anxiety impacted on the participants' willingness to be vaccinated. One reason for being undecided about the vaccine was that participants felt they did not know enough about it. Practising social distancing increased willingness to be vaccinated, as reflected in the qualitative results which showed participants wanted to be vaccinated to protect others. The results impart important knowledge to healthcare professionals and contribute to their communication with adolescents about vaccine hesitancy.", "doi": "10.1016/j.jvacx.2021.100117", "pmid": "34693273", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S2590-1362(21)00034-6"}, {"db": "pmc", "key": "PMC8524812"}], "notes": [], "created": "2021-10-26T18:23:43.089Z", "modified": "2021-11-29T06:17:03.926Z"}, {"entity": "publication", "iuid": "a50334cf1c724ceaa95e3cc107ba0693", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a50334cf1c724ceaa95e3cc107ba0693.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a50334cf1c724ceaa95e3cc107ba0693"}}, "title": "The Unyvero Hospital-Acquired pneumonia panel for diagnosis of secondary bacterial pneumonia in COVID-19 patients.", "authors": [{"family": "Tellapragada", "given": "Chaitanya", "initials": "C"}, {"family": "Giske", "given": "Christian G", "initials": "CG"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Eur J Clin Microbiol Infect Dis", "issn": "1435-4373", "volume": "40", "issue": "12", "pages": "2479-2485", "issn-l": null}, "abstract": "The study was undertaken to evaluate the performance of Unyvero Hospitalized Pneumonia (HPN) panel application, a multiplex PCR-based method for the detection of bacterial pathogens from lower respiratory tract (LRT) samples, obtained from COVID-19 patients with suspected secondary hospital-acquired pneumonia. Residual LRT samples obtained from critically ill COVID-19 patients with predetermined microbiological culture results were tested using the Unyvero HPN Application. Performance evaluation of the HPN Application was carried out using the standard-of-care (SoC) microbiological culture findings as the reference method. Eighty-three LRT samples were used in the evaluation. The HPN Application had a full concordance with SoC findings in 59/83 (71%) samples. The new method detected additional bacterial species in 21 (25%) and failed at detecting a bacterial species present in lower respiratory culture in 3 (3.6%) samples. Overall the sensitivity, specificity, positive, and negative predictive values of the HPN Application were 95.1% (95%CI 96.5-98.3%), 98.3% (95% CI 97.5-98.9%), 71.6% (95% CI 61.0-80.3%), and 99.8% (95% CI 99.3-99.9%), respectively. In conclusion, the HPN Application demonstrated higher diagnostic yield in comparison with the culture and generated results within 5 h.", "doi": "10.1007/s10096-021-04194-6", "pmid": "33661410", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10096-021-04194-6"}, {"db": "pmc", "key": "PMC7930892"}], "notes": [], "created": "2021-03-06T10:23:44.394Z", "modified": "2021-11-18T12:18:22.450Z"}, {"entity": "publication", "iuid": "706709cf6e124a22a1aa0c37efde7172", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/706709cf6e124a22a1aa0c37efde7172.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/706709cf6e124a22a1aa0c37efde7172"}}, "title": "Swedish middle school students' psychosocial well-being during the COVID-19 pandemic: A longitudinal study.", "authors": [{"family": "Vira", "given": "Emily G", "initials": "EG"}, {"family": "Skoog", "given": "Ther\u00e9se", "initials": "T"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "SSM Popul Health", "issn": "2352-8273", "volume": "16", "pages": "100942", "issn-l": null}, "abstract": "Child well-being concerns amidst the COVID-19 pandemic have been reported from countries with strict lockdowns and school closures. Sweden's middle school students attended school as normal during the pandemic, but it is still unknown how their well-being has changed during the pandemic. This study aimed to assess differences in Swedish students' psychosocial well-being from before to during the pandemic. Longitudinal data (N = 849) were collected via self-report surveys across two time-points separated by approximately one year. The second data collection took place 8-9 months after the start of the pandemic in Sweden. We measured psychological adjustment, relationships to significant others and school adjustment. Findings revealed significant mean-level decreases in students' school adjustment during the pandemic. There were no meaningful mean-level decreases in students' relationships to significant others. Students' psychological adjustment showed significant but mostly negligible mean-level decreases, and no differences in emotional problems during the pandemic. The findings are explained based on students' developmental stage and the handling of the pandemic in the Swedish school context. Based on this first longitudinal study on students' wellbeing during the COVID-19 pandemic, we conclude that Swedish middle school students who continued formal schooling show mainly positive adaptations, and thus appear to be resilient during the COVID-19 pandemic.", "doi": "10.1016/j.ssmph.2021.100942", "pmid": "34664029", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2352-8273(21)00217-2"}, {"db": "pmc", "key": "PMC8516135"}], "notes": [], "created": "2021-10-21T04:57:18.209Z", "modified": "2021-10-21T04:57:18.231Z"}, {"entity": "publication", "iuid": "078e400f924141a7b6ac8c40f1daf541", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/078e400f924141a7b6ac8c40f1daf541.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/078e400f924141a7b6ac8c40f1daf541"}}, "title": "Revival of ecological studies during the COVID-19 pandemic.", "authors": [{"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}, {"family": "Modig", "given": "Karin", "initials": "K"}, {"family": "Kahn", "given": "Fredrik", "initials": "F"}, {"family": "Ahlbom", "given": "Anders", "initials": "A", "orcid": "0000-0003-1093-1901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f33a2deb34d945878518ba196b3f6728.json"}}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Eur J Epidemiol", "issn": "1573-7284", "volume": "36", "issue": "12", "pages": "1225-1229", "issn-l": "0393-2990"}, "abstract": null, "doi": "10.1007/s10654-021-00830-9", "pmid": "34951671", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10654-021-00830-9"}, {"db": "pmc", "key": "PMC8703212"}], "notes": [], "created": "2022-01-04T15:26:57.207Z", "modified": "2022-01-04T15:27:31.950Z"}, {"entity": "publication", "iuid": "904eec4259f24c22aa26316b21f08c15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/904eec4259f24c22aa26316b21f08c15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/904eec4259f24c22aa26316b21f08c15"}}, "title": "Respiratory infection risk-based ventilation design method.", "authors": [{"family": "Kurnitski", "given": "Jarek", "initials": "J"}, {"family": "Kiil", "given": "Martin", "initials": "M"}, {"family": "Wargocki", "given": "Pawel", "initials": "P"}, {"family": "Boerstra", "given": "Atze", "initials": "A"}, {"family": "Sepp\u00e4nen", "given": "Olli", "initials": "O"}, {"family": "Olesen", "given": "Bjarne", "initials": "B"}, {"family": "Morawska", "given": "Lidia", "initials": "L"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Build Environ", "issn": "0360-1323", "volume": "206", "pages": "108387", "issn-l": null}, "abstract": "A new design method is proposed to calculate outdoor air ventilation rates to control respiratory infection risk in indoor spaces. We propose to use this method in future ventilation standards to complement existing ventilation criteria based on the perceived air quality and pollutant removal. The proposed method makes it possible to calculate the required ventilation rate at a given probability of infection and quanta emission rate. Present work used quanta emission rates for SARS-CoV-2 and consequently the method can be applied for other respiratory viruses with available quanta data. The method was applied to case studies representing typical rooms in public buildings. To reduce the probability of infection, the total airflow rate per infectious person revealed to be the most important parameter to reduce the infection risk. Category I ventilation rate prescribed in the EN 16798-1 standard satisfied many but not all type of spaces examined. The required ventilation rates started from about 80 L/s per room. Large variations between the results for the selected case studies made it impossible to provide a simple rule for estimating the required ventilation rates. Consequently, we conclude that to design rooms with a low infection risk the newly developed ventilation design method must be used.", "doi": "10.1016/j.buildenv.2021.108387", "pmid": "34602721", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0360-1323(21)00784-8"}, {"db": "pmc", "key": "PMC8462055"}], "notes": [], "created": "2021-10-11T18:01:41.194Z", "modified": "2021-10-11T18:01:41.235Z"}, {"entity": "publication", "iuid": "ad6319278115441b8d67e949c2c8929f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ad6319278115441b8d67e949c2c8929f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ad6319278115441b8d67e949c2c8929f"}}, "title": "Patterns and predictors of sick leave after Covid-19 and long Covid in a national Swedish cohort", "authors": [{"family": "Westerlind", "given": "Emma", "initials": "E"}, {"family": "Palstam", "given": "Annie", "initials": "A"}, {"family": "Sunnerhagen", "given": "Katharina S", "initials": "KS"}, {"family": "Persson", "given": "Hanna C", "initials": "HC"}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "1023"}, "abstract": "The impact of Covid-19 and its long-term consequences is not yet fully understood. Sick leave can be seen as an indicator of health in a working age population, and the present study aimed to investigate sick-leave patterns after Covid-19, and potential factors predicting longer sick leave in hospitalised and non-hospitalised people with Covid-19.\r\n\r\nThe present study is a comprehensive national registry-based study in Sweden with a 4-month follow-up. All people who started to receive sickness benefits for Covid-19 during March 1 to August 31, 2020, were included. Predictors of sick leave \u22651 month and long Covid (\u226512 weeks) were analysed with logistic regression in the total population and in separate models depending on inpatient care due to Covid-19.\r\n\r\nA total of 11,955 people started sick leave for Covid-19 within the inclusion period. The median sick leave was 35 days, 13.3% were on sick leave for long Covid, and 9.0% remained on sick leave for the whole follow-up period. There were 2960 people who received inpatient care due to Covid-19, which was the strongest predictor of longer sick leave. Sick leave the year prior to Covid-19 and older age also predicted longer sick leave. No clear pattern of socioeconomic factors was noted.\r\n\r\nA substantial number of people are on sick leave due to Covid-19. Sick leave may be protracted, and sick leave for long Covid is quite common. The severity of Covid-19 (needing inpatient care), prior sick leave, and age all seem to predict the likelihood of longer sick leave. However, no socioeconomic factor could clearly predict longer sick leave, indicating the complexity of this condition. The group needing long sick leave after Covid-19 seems to be heterogeneous, indicating a knowledge gap.", "doi": "10.1186/s12889-021-11013-2", "pmid": "34059034", "labels": {"Category: Rehabilitation": null, "Category: Post-COVID": null, "Type: Journal article": null, "Funder: Forte": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11013-2"}], "notes": [], "created": "2021-06-02T13:13:29.154Z", "modified": "2021-11-19T10:41:14.086Z"}, {"entity": "publication", "iuid": "f3ea01c51f5943808fabda31a757f721", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f3ea01c51f5943808fabda31a757f721.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f3ea01c51f5943808fabda31a757f721"}}, "title": "Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study.", "authors": [{"family": "Sattui", "given": "Sebastian E", "initials": "SE"}, {"family": "Conway", "given": "Richard", "initials": "R"}, {"family": "Putman", "given": "Michael S", "initials": "MS"}, {"family": "Seet", "given": "Andrea M", "initials": "AM"}, {"family": "Gianfrancesco", "given": "Milena A", "initials": "MA"}, {"family": "Beins", "given": "Kaley", "initials": "K"}, {"family": "Hill", "given": "Catherine", "initials": "C"}, {"family": "Liew", "given": "David", "initials": "D"}, {"family": "Mackie", "given": "Sarah L", "initials": "SL"}, {"family": "Mehta", "given": "Puja", "initials": "P"}, {"family": "Neill", "given": "Lorna", "initials": "L"}, {"family": "Gomez", "given": "Gimena", "initials": "G"}, {"family": "Salinas", "given": "Maria Isabel Haye", "initials": "MIH"}, {"family": "Maldonado", "given": "Federico Nicolas", "initials": "FN"}, {"family": "Mariz", "given": "Henrique Ataide", "initials": "HA"}, {"family": "de Sousa Studart", "given": "Samia Araujo", "initials": "SA"}, {"family": "Araujo", "given": "Nafice Costa", "initials": "NC"}, {"family": "Knight", "given": "Ann", "initials": "A"}, {"family": "Rozza", "given": "Davide", "initials": "D"}, {"family": "Quartuccio", "given": "Luca", "initials": "L"}, {"family": "Samson", "given": "Maxime", "initials": "M"}, {"family": "Bally", "given": "St\u00e9phane", "initials": "S"}, {"family": "Maria", "given": "Alexandre Tj", "initials": "AT"}, {"family": "Chazerain", "given": "Pascal", "initials": "P"}, {"family": "Hasseli", "given": "Rebecca", "initials": "R"}, {"family": "M\u00fcller-Ladner", "given": "Ulf", "initials": "U"}, {"family": "Hoyer", "given": "Bimba F", "initials": "BF"}, {"family": "Voll", "given": "Reinhard", "initials": "R"}, {"family": "Torres", "given": "Rita Pinheiro", "initials": "RP"}, {"family": "Luis", "given": "Mariana", "initials": "M"}, {"family": "Ribeirio", "given": "Sandra Lucia Euzebio", "initials": "SLE"}, {"family": "Al-Emadi", "given": "Samar", "initials": "S"}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA"}, {"family": "Hsu", "given": "Tiffany Y-T", "initials": "TY"}, {"family": "D'Silva", "given": "Kristin M", "initials": "KM"}, {"family": "Patel", "given": "Naomi J", "initials": "NJ"}, {"family": "Wise", "given": "Leanna", "initials": "L"}, {"family": "Gilbert", "given": "Emily", "initials": "E"}, {"family": "Almada", "given": "Maria Valenzuela", "initials": "MV"}, {"family": "Duarte-Garc\u00eda", "given": "Al\u00ed", "initials": "A"}, {"family": "Ugarte-Gil", "given": "Manuel", "initials": "M"}, {"family": "Jacobsohn", "given": "Lindsay", "initials": "L"}, {"family": "Izadi", "given": "Zara", "initials": "Z"}, {"family": "Strangfeld", "given": "Anja", "initials": "A"}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL"}, {"family": "Gossec", "given": "Laure", "initials": "L"}, {"family": "Carmona", "given": "Loreto", "initials": "L"}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S"}, {"family": "Kearsley-Fleet", "given": "Lianne", "initials": "L"}, {"family": "Schaefer", "given": "Martin", "initials": "M"}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS"}, {"family": "Sufka", "given": "Paul", "initials": "P"}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Grainger", "given": "Rebecca", "initials": "R"}, {"family": "Machado", "given": "Pedro M", "initials": "PM"}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Yazdany", "given": "Jinoos", "initials": "J"}, {"family": "Robinson", "given": "Philip C", "initials": "PC"}, {"family": "Global Rheumatology Alliance", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Lancet Rheumatol", "issn": "2665-9913", "volume": "3", "issue": "12", "pages": "e855-e864", "issn-l": null}, "abstract": "Patients with primary systemic vasculitis or polymyalgia rheumatica might be at a high risk for poor COVID-19 outcomes due to the treatments used, the potential organ damage cause by primary systemic vasculitis, and the demographic factors associated with these conditions. We therefore aimed to investigate factors associated with COVID-19 outcomes in patients with primary systemic vasculitis or polymyalgia rheumatica.\n\nIn this retrospective cohort study, adult patients (aged \u226518 years) diagnosed with COVID-19 between March 12, 2020, and April 12, 2021, who had a history of primary systemic vasculitis (antineutrophil cytoplasmic antibody [ANCA]-associated vasculitis, giant cell arteritis, Beh\u00e7et's syndrome, or other vasculitis) or polymyalgia rheumatica, and were reported to the COVID-19 Global Rheumatology Alliance registry were included. To assess COVID-19 outcomes in patients, we used an ordinal COVID-19 severity scale, defined as: (1) no hospitalisation; (2) hospitalisation without supplemental oxygen; (3) hospitalisation with any supplemental oxygen or ventilation; or (4) death. Multivariable ordinal logistic regression analyses were used to estimate odds ratios (ORs), adjusting for age, sex, time period, number of comorbidities, smoking status, obesity, glucocorticoid use, disease activity, region, and medication category. Analyses were also stratified by type of rheumatic disease.\n\nOf 1202 eligible patients identified in the registry, 733 (61\u00b70%) were women and 469 (39\u00b70%) were men, and their mean age was 63\u00b78 years (SD 17\u00b71). A total of 374 (31\u00b71%) patients had polymyalgia rheumatica, 353 (29\u00b74%) had ANCA-associated vasculitis, 183 (15\u00b72%) had giant cell arteritis, 112 (9\u00b73%) had Beh\u00e7et's syndrome, and 180 (15\u00b70%) had other vasculitis. Of 1020 (84\u00b79%) patients with outcome data, 512 (50\u00b72%) were not hospitalised, 114 (11\u00b72%) were hospitalised and did not receive supplemental oxygen, 239 (23\u00b74%) were hospitalised and received ventilation or supplemental oxygen, and 155 (15\u00b72%) died. A higher odds of poor COVID-19 outcomes were observed in patients who were older (per each additional decade of life OR 1\u00b744 [95% CI 1\u00b731-1\u00b757]), were male compared with female (1\u00b738 [1\u00b705-1\u00b780]), had more comorbidities (per each additional comorbidity 1\u00b739 [1\u00b723-1\u00b758]), were taking 10 mg/day or more of prednisolone compared with none (2\u00b714 [1\u00b750-3\u00b704]), or had moderate, or high or severe disease activity compared with those who had disease remission or low disease activity (2\u00b712 [1\u00b749-3\u00b702]). Risk factors varied among different disease subtypes.\n\nAmong patients with primary systemic vasculitis and polymyalgia rheumatica, severe COVID-19 outcomes were associated with variable and largely unmodifiable risk factors, such as age, sex, and number of comorbidities, as well as treatments, including high-dose glucocorticoids. Our results could be used to inform mitigation strategies for patients with these diseases.\n\nAmerican College of Rheumatology and the European Alliance of Associations for Rheumatology.", "doi": "10.1016/S2665-9913(21)00316-7", "pmid": "34778843", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2665-9913(21)00316-7"}, {"db": "pmc", "key": "PMC8570701"}], "notes": [], "created": "2021-11-26T14:13:12.026Z", "modified": "2021-11-26T14:13:12.041Z"}, {"entity": "publication", "iuid": "74a2d3a88e74486eb9d5899b4fbb201d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/74a2d3a88e74486eb9d5899b4fbb201d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/74a2d3a88e74486eb9d5899b4fbb201d"}}, "title": "Nudging healthcare professionals to improve treatment of COVID-19: a narrative review", "authors": [{"family": "Vilhelmsson", "given": "Andreas", "initials": "A", "orcid": "0000-0002-6635-8182", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48e38ddf17384577a77c07639249ecc8.json"}}, {"family": "Sant'Anna", "given": "Anita", "initials": "A"}, {"family": "Wolf", "given": "Axel", "initials": "A"}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "BMJ Open Qual", "issn": "2399-6641", "volume": "10", "issue": "4", "pages": "e001522", "issn-l": null}, "abstract": null, "doi": "10.1136/bmjoq-2021-001522", "pmid": null, "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:54:04.021Z", "modified": "2021-12-12T06:54:04.271Z"}, {"entity": "publication", "iuid": "5d2e70aff6164745ab02cd7192646084", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d2e70aff6164745ab02cd7192646084.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d2e70aff6164745ab02cd7192646084"}}, "title": "Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms.", "authors": [{"family": "Zhong", "given": "Wen", "initials": "W"}, {"family": "Altay", "given": "Ozlem", "initials": "O"}, {"family": "Arif", "given": "Muhammad", "initials": "M"}, {"family": "Edfors", "given": "Fredrik", "initials": "F"}, {"family": "Doganay", "given": "Levent", "initials": "L"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A"}, {"family": "Uhlen", "given": "Mathias", "initials": "M"}, {"family": "Fagerberg", "given": "Linn", "initials": "L", "orcid": "0000-0003-0198-7137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/735a371341c246a88f09c1efea5a5f57.json"}}], "type": "clinical trial, phase ii", "published": "2021-12-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "volume": "74", "pages": "103723", "issn-l": null}, "abstract": "COVID-19 has caused millions of deaths globally, yet the cellular mechanisms underlying the various effects of the disease remain poorly understood. Recently, a new analytical platform for comprehensive analysis of plasma protein profiles using proximity extension assays combined with next generation sequencing has been developed, which allows for multiple proteins to be analyzed simultaneously without sacrifice on accuracy or sensitivity.\n\nWe analyzed the plasma protein profiles of COVID-19 patients (n = 50) with mild and moderate symptoms by comparing the protein levels in newly diagnosed patients with the protein levels in the same individuals after 14 days.\n\nThe study has identified more than 200 proteins that are significantly elevated during infection and many of these are related to cytokine response and other immune-related functions. In addition, several other proteins are shown to be elevated, including SCARB2, a host cell receptor protein involved in virus entry. A comparison with the plasma protein response in patients with severe symptoms shows a highly similar pattern, but with some interesting differences.\n\nThe study presented here demonstrates the usefulness of \"next generation plasma protein profiling\" to identify molecular signatures of importance for disease progression and to allow monitoring of disease during recovery from the infection. The results will facilitate further studies to understand the molecular mechanism of the immune-related response of the SARS-CoV-2 virus.\n\nThis work was financially supported by Knut and Alice Wallenberg Foundation.", "doi": "10.1016/j.ebiom.2021.103723", "pmid": "34844191", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8626206"}, {"db": "pii", "key": "S2352-3964(21)00517-X"}], "notes": [], "created": "2021-12-18T18:11:33.370Z", "modified": "2023-06-19T15:39:44.480Z"}, {"entity": "publication", "iuid": "635551968c97474e8cc1a35c1be3193d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/635551968c97474e8cc1a35c1be3193d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/635551968c97474e8cc1a35c1be3193d"}}, "title": "National health governance, science and the media: drivers of COVID-19 responses in Germany, Sweden and the UK in 2020.", "authors": [{"family": "Hanson", "given": "Claudia", "initials": "C", "orcid": "0000-0001-8066-7873", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c06a2e703c840788ccdf3b2c4c972bc.json"}}, {"family": "Luedtke", "given": "Susanne", "initials": "S"}, {"family": "Spicer", "given": "Neil", "initials": "N"}, {"family": "Stilhoff S\u00f6rensen", "given": "Jens", "initials": "J"}, {"family": "Mayhew", "given": "Susannah", "initials": "S"}, {"family": "Mounier-Jack", "given": "Sandra", "initials": "S"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "12", "issn-l": "2059-7908"}, "abstract": "The COVID-19 pandemic is an unprecedented global crisis in which governments had to act in a situation of rapid change and substantial uncertainty. The governments of Germany, Sweden and the UK have taken different paths allowing learning for future pandemic preparedness. To help inform discussions on preparedness, inspired by resilience frameworks, this paper reviews governance structures, and the role of science and the media in the COVID-19 response of Germany, Sweden and the UK in 2020. We mapped legitimacy, interdependence, knowledge generation and the capacity to deal with uncertainty.Our analysis revealed stark differences which were linked to pre-existing governing structures, the traditional role of academia, experience of crisis management and the communication of uncertainty-all of which impacted on how much people trusted their government. Germany leveraged diversity and inclusiveness, a 'patchwork quilt', for which it was heavily criticised during the second wave. The Swedish approach avoided plurality and largely excluded academia, while in the UK's academia played an important role in knowledge generation and in forcing the government to review its strategies. However, the vivant debate left the public with confusing and rapidly changing public health messages. Uncertainty and the lack of evidence on how best to manage the COVID-19 pandemic-the main feature during the first wave-was only communicated explicitly in Germany. All country governments lost trust of their populations during the epidemic due to a mix of communication and transparency failures, and increased questioning of government legitimacy and technical capacity by the public.", "doi": "10.1136/bmjgh-2021-006691", "pmid": "34872972", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8764706"}, {"db": "pii", "key": "bmjgh-2021-006691"}], "notes": [], "created": "2021-12-12T07:10:21.949Z", "modified": "2023-01-13T13:28:12.610Z"}, {"entity": "publication", "iuid": "a957c1c71ff2471b879730385ff59136", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a957c1c71ff2471b879730385ff59136.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a957c1c71ff2471b879730385ff59136"}}, "title": "More than 50 long-term effects of COVID-19: a systematic review and meta-analysis", "authors": [{"family": "Lopez-Leon", "given": "Sandra", "initials": "S", "orcid": "0000-0001-7504-3441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/311cfec51fe9447283ee5c3a4ca0a3cd.json"}}, {"family": "Wegman-Ostrosky", "given": "Talia", "initials": "T", "orcid": "0000-0002-3207-6697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ebacfc4db6e4a04aab46b7172d828f2.json"}}, {"family": "Perelman", "given": "Carol", "initials": "C", "orcid": "0000-0002-0111-1154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb4874d2c45c4d698c57f5e3705d306d.json"}}, {"family": "Sepulveda", "given": "Rosalinda", "initials": "R", "orcid": "0000-0003-1146-9552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e217c9ab8c24eeca127ffb1dd89b843.json"}}, {"family": "Rebolledo", "given": "Paulina A", "initials": "PA", "orcid": "0000-0002-9808-063X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bbee43f79e147b39028119e0b573c72.json"}}, {"family": "Cuapio", "given": "Angelica", "initials": "A", "orcid": "0000-0002-9451-1914", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f4915fdfa7d460f9b705b56b0fc1c4a.json"}}, {"family": "Villapol", "given": "Sonia", "initials": "S", "orcid": "0000-0002-6174-4113", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04eb73dcc16546b0b153a41bcba039af.json"}}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": null}, "abstract": null, "doi": "10.1038/s41598-021-95565-8", "pmid": null, "labels": {"Type: Preprint": null, "Type: Review": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-17T19:33:26.821Z", "modified": "2022-07-06T04:52:15.537Z"}, {"entity": "publication", "iuid": "508d0a8b8a5a4f6684354585ced2f945", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/508d0a8b8a5a4f6684354585ced2f945.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/508d0a8b8a5a4f6684354585ced2f945"}}, "title": "Measuring changes in alcohol use in Finland and Norway during the COVID-19 pandemic: Comparison between data sources.", "authors": [{"family": "M\u00e4kel\u00e4", "given": "Pia", "initials": "P", "orcid": "0000-0002-3343-2139", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c978b04d84144cb694a974c01022890b.json"}}, {"family": "Rossow", "given": "Ingeborg", "initials": "I", "orcid": "0000-0001-8652-9367", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab426c14c36143d0bd2da8eb86f74e97.json"}}, {"family": "Moan", "given": "Inger Synn\u00f8ve", "initials": "IS", "orcid": "0000-0002-9021-8665", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fd744b5fb9f46e6868ab5b624ce81e4.json"}}, {"family": "Bye", "given": "Elin K", "initials": "EK", "orcid": "0000-0001-7559-8885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98e8956f35d94c1c8142605e7cdb51f7.json"}}, {"family": "Kilian", "given": "Carolin", "initials": "C", "orcid": "0000-0001-5913-6488", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed0409bb90b346cd9001bebb46bdcf87.json"}}, {"family": "Raitasalo", "given": "Kirsimarja", "initials": "K", "orcid": "0000-0001-7909-8562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28001f1928d44b98af9bd7d509477ae3.json"}}, {"family": "Allebeck", "given": "Peter", "initials": "P", "orcid": "0000-0002-2778-6467", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de9f0e1c3e4d402b93e61ad1c5a771fb.json"}}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Int J Methods Psychiatr Res", "issn": "1557-0657", "issn-l": null, "volume": "30", "issue": "4", "pages": "e1892"}, "abstract": "To examine (1) how a rapid data collection using a convenience sample fares in estimating change in alcohol consumption when compared to more conventional data sources, and (2) how alcohol consumption changed in Finland and Norway during the first months of the COVID-19 pandemic.\n\nThree different types of data sources were used for the 2nd quarter of 2020 and 2019: sales statistics combined with data on unrecorded consumption; the rapid European Alcohol Use and COVID-19 (ESAC) survey (Finland: n = 3800, Norway: n = 17,092); and conventional population surveys (Finland: n = 2345, Norway: n1 = 1328, n2 = 2189, n3 = 25,708). Survey measures of change were retrospective self-reports.\n\nThe statistics indicate that alcohol consumption decreased in Finland by 9%, while little change was observed in Norway. In all surveys, reporting a decrease in alcohol use was more common than reporting an increase (ratios 2-2.6 in Finland, 1.3-2 in Norway). Compared to conventional surveys, in the ESAC survey fewer respondents reported no change and past-year alcohol consumption was higher.\n\nThe rapid survey using convenience sampling gave similar results on change in drinking as conventional surveys but higher past-year drinking, suggesting self-selection effects. Aspects of the pandemic driving alcohol consumption down were equally strong or stronger than those driving it up.", "doi": "10.1002/mpr.1892", "pmid": "34449127", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8633923"}], "notes": [], "created": "2021-09-01T07:29:54.053Z", "modified": "2023-06-19T07:32:29.877Z"}, {"entity": "publication", "iuid": "e3b9bb4510224866b575e818109cc8b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3b9bb4510224866b575e818109cc8b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3b9bb4510224866b575e818109cc8b0"}}, "title": "Mapping the human genetic architecture of COVID-19.", "authors": [{"family": "COVID-19 Host Genetics Initiative", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Nature", "issn": "1476-4687", "issn-l": "0028-0836", "volume": "600", "issue": "7889", "pages": "472-477"}, "abstract": "The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3-7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.", "doi": "10.1038/s41586-021-03767-x", "pmid": "34237774", "labels": {"Funder: VR": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Research Area: Vaccine": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41586-021-03767-x"}, {"db": "pmc", "key": "PMC8674144"}], "notes": [], "created": "2021-08-06T10:53:44.989Z", "modified": "2022-02-06T17:38:20.820Z"}, {"entity": "publication", "iuid": "b8e256df3ccd48239acb1ee143624cfb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8e256df3ccd48239acb1ee143624cfb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8e256df3ccd48239acb1ee143624cfb"}}, "title": "Managers of micro-sized enterprises and Covid-19: impact on business operations, work-life balance and well-being.", "authors": [{"family": "Vinberg", "given": "Stig", "initials": "S", "orcid": "0000-0002-5935-5688", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c63c4ca58d242d18741dba0b0af5afb.json"}}, {"family": "Danielsson", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Int J Circumpolar Health", "issn": "2242-3982", "volume": "80", "issue": "1", "pages": "1959700", "issn-l": null}, "abstract": "The aim of this study is to identify how managers of micro-sized enterprises experience the impact of the Covid-19 pandemic on their business operations, work-life balance and well-being. Further, the study aims to make comparisons between managers of micro-sized businesses and managers of small-sized businesses. This mixed-method study is based on qualitative interviews with ten managers of micro-sized enterprises and a questionnaire answered by 95 managers of micro-sized and small-sized enterprises in regions in the north of Sweden. Managers of micro-sized enterprises reported significantly worse scores for mental well-being, job satisfaction and life satisfaction in comparison with managers of small-sized enterprises. Three themes emerged from the qualitative analysis: Changed leadership role, Impact on private life and Impact on well-being. In the interviews, the managers of micro-sized enterprises reported that the pandemic had increased their workload and forced them to mobilise strategies for enterprise survival. This study indicates that managers of micro-sized enterprises had changed their leadership role and increased their workload and number of work tasks, including supporting the employees, developing strategies for business survival and applying for governmental support. However, the managers demonstrated creativity in finding new solutions for their enterprises.", "doi": "10.1080/22423982.2021.1959700", "pmid": "34378496", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-08-12T17:06:29.217Z", "modified": "2021-08-12T17:08:20.118Z"}, {"entity": "publication", "iuid": "ea0c1b175467424bbc1e77816c8aa57d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ea0c1b175467424bbc1e77816c8aa57d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ea0c1b175467424bbc1e77816c8aa57d"}}, "title": "Insecurity, lack of support, and frustration: A sociological analysis of how three groups of students reflect on their distance education during the pandemic in Sweden.", "authors": [{"family": "Lidegran", "given": "Ida", "initials": "I", "orcid": "0000-0003-3193-5565", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d260c6beaac7465ea0a6c426ee30008f.json"}}, {"family": "Hultqvist", "given": "Elisabeth", "initials": "E"}, {"family": "Bertilsson", "given": "Emil", "initials": "E"}, {"family": "B\u00f6rjesson", "given": "Mikael", "initials": "M"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Eur J Educ", "issn": "1465-3435", "issn-l": null, "volume": "56", "issue": "4", "pages": "550-563"}, "abstract": "This article investigates the situation of Swedish upper secondary school students who have been subject to distance education during the COVID-19 pandemic crisis. We understand the transition from onsite education to distance education as a recontextualization of pedagogical practice, our framing follows loosely concepts from Bernstein. Given that the field of upper secondary education is highly socially structured it is relevant to enquire into the social dimensions of distance education. For this purpose, we have analysed answers to an open-ended question in a survey answered by 3,726 students, and related them to a cluster analysis distinguishing three main clusters of students: urban upper-middle-class, immigrant working-class, and rural working-class. The urban upper-middle-class students experienced problems decoding new requirements and were troubled by blurred boundaries between school and home. This group invests the most in schooling, and therefore expresses comparatively more anxiety for reaching anticipated achievements. Immigrant working-class students were comparatively more discontented by a lack of school support and request clearer instructions. In this new educational situation, characterized by a weak framing, they have difficulties decoding the requirements. The rural working-class students appear comparatively more disconnected from the school situation. Unlike urban upper-middle-class students, for whom the school invades the home and private sphere, the rural working-class students seldom experienced that the school intruded their home; accordingly, their studies collapsed into sleep-in-mornings and a holiday feeling.", "doi": "10.1111/ejed.12477", "pmid": "34898738", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "EJED12477"}, {"db": "pmc", "key": "PMC8646562"}], "notes": [], "created": "2021-12-18T18:00:37.973Z", "modified": "2022-11-22T05:44:45.823Z"}, {"entity": "publication", "iuid": "086c3c198dec478c9ddc11bc755e5ff8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/086c3c198dec478c9ddc11bc755e5ff8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/086c3c198dec478c9ddc11bc755e5ff8"}}, "title": "Initial assessment of the COVID-19 vaccination's impact on case numbers, hospitalisations and deaths in people aged 80 years and older, 15 EU/EEA countries, December 2020 to May 2021.", "authors": [{"family": "Nicolay", "given": "Nathalie", "initials": "N"}, {"family": "Innocenti", "given": "Francesco", "initials": "F"}, {"family": "Beaut\u00e9", "given": "Julien", "initials": "J"}, {"family": "U\u010dakar", "given": "Veronika", "initials": "V"}, {"family": "Grgi\u010d Vitek", "given": "Marta", "initials": "M"}, {"family": "Poukka", "given": "Eero", "initials": "E"}, {"family": "Hannila-Handelberg", "given": "Tuula", "initials": "T"}, {"family": "Gauci", "given": "Charmaine", "initials": "C"}, {"family": "Melillo", "given": "Tanya", "initials": "T"}, {"family": "Georgakopoulou", "given": "Theano", "initials": "T"}, {"family": "Jarkovsky", "given": "Jiri", "initials": "J"}, {"family": "Slezak", "given": "Pavel", "initials": "P"}, {"family": "Delgado-Sanz", "given": "Concepci\u00f3n", "initials": "C"}, {"family": "Olmedo-Lucer\u00f3n", "given": "Carmen", "initials": "C"}, {"family": "Suija", "given": "Heleene", "initials": "H"}, {"family": "Liausediene", "given": "Rasa", "initials": "R"}, {"family": "O'Lorcain", "given": "Piaras", "initials": "P"}, {"family": "Murphy", "given": "Niamh", "initials": "N"}, {"family": "Peralta-Santos", "given": "Andr\u00e9", "initials": "A"}, {"family": "Casaca", "given": "Pedro", "initials": "P"}, {"family": "Gregoriou", "given": "Ioanna", "initials": "I"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Spiteri", "given": "Gianfranco", "initials": "G"}, {"family": "Ravasi", "given": "Giovanni", "initials": "G"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "48", "issn-l": null}, "abstract": "Prioritisation of elderly people in COVID-19 vaccination campaigns aimed at reducing severe outcomes in this group. Using EU/EEA surveillance and vaccination uptake, we estimated the risk ratio of case, hospitalisation and death notifications in people 80 years and older compared with 25-59-year-olds. Highest impact was observed for full vaccination uptake 80% or higher with reductions in notification rates of cases up to 65% (IRR: 0.35; 95% CI: 0.13-0.99), hospitalisations up to 78% (IRR: 0.22; 95% CI: 0.13-0.37) and deaths up to 84% (IRR: 0.16; 95% CI: 0.13-0.20).", "doi": "10.2807/1560-7917.ES.2021.26.48.2101030", "pmid": "34857068", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8641072"}], "notes": [], "created": "2021-12-18T18:07:47.120Z", "modified": "2021-12-18T18:07:47.135Z"}, {"entity": "publication", "iuid": "9288b382d01b42629711ac1c5ae10c9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9288b382d01b42629711ac1c5ae10c9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9288b382d01b42629711ac1c5ae10c9c"}}, "title": "Human papillomavirus vaccination in the European Union/European Economic Area and globally: a moral dilemma.", "authors": [{"family": "Colzani", "given": "Edoardo", "initials": "E"}, {"family": "Johansen", "given": "Kari", "initials": "K"}, {"family": "Johnson", "given": "Helen", "initials": "H"}, {"family": "Pastore Celentano", "given": "Lucia", "initials": "L"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "50", "issn-l": null}, "abstract": "While many European Union/European Economic Area (EU/EEA) countries recently expanded human papillomavirus (HPV) vaccination to boys, HPV vaccine supply is currently limited for girls in low- and middle-income countries (LMIC) that are severely affected by HPV.Globally, about 50% of countries have introduced HPV vaccination. Some LMIC with high burden of cervical cancer have not yet introduced HPV vaccination, or are reaching suboptimal vaccination coverage. While WHO issued a call for cervical cancer elimination in 2018, a global shortage of HPV vaccines is currently predicted to last at least until 2024.We reviewed national policies of EU/EEA countries and recommendations of the World Health Organization (WHO) Strategic Advisory Group of Experts on immunisation to discuss current challenges and dose-sparing options. Several EU/EEA countries have extended HPV vaccination to boys and the European Cancer Organisation has issued a resolution for elimination of all HPV-associated cancers in both sexes. The European Centre for Disease Prevention and Control concluded in its 2020 guidance that cost-effectiveness of extending routine vaccination to boys depends on several context-specific factors. The extension of HPV vaccination to boys in EU/EEA countries may affect global availability of vaccines. Temporary dose-sparing options could be considered during the COVID-19 post-pandemic period.", "doi": "10.2807/1560-7917.ES.2021.26.50.2001659", "pmid": "34915976", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T17:44:17.021Z", "modified": "2021-12-18T17:44:17.034Z"}, {"entity": "publication", "iuid": "5d377c22678c463fb0fcddfaf34db158", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d377c22678c463fb0fcddfaf34db158.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d377c22678c463fb0fcddfaf34db158"}}, "title": "Epidemiological characterisation of the first 785 SARS-CoV-2 Omicron variant cases in Denmark, December 2021.", "authors": [{"family": "Espenhain", "given": "Laura", "initials": "L"}, {"family": "Funk", "given": "Tjede", "initials": "T"}, {"family": "Overvad", "given": "Maria", "initials": "M"}, {"family": "Edslev", "given": "Sofie Marie", "initials": "SM"}, {"family": "Fonager", "given": "Jannik", "initials": "J"}, {"family": "Ingham", "given": "Anna C\u00e4cilia", "initials": "AC"}, {"family": "Rasmussen", "given": "Morten", "initials": "M"}, {"family": "Madsen", "given": "Sarah Leth", "initials": "SL"}, {"family": "Espersen", "given": "Caroline Hjorth", "initials": "CH"}, {"family": "Sieber", "given": "Raphael N", "initials": "RN"}, {"family": "Stegger", "given": "Marc", "initials": "M"}, {"family": "Gunalan", "given": "Vithiagaran", "initials": "V"}, {"family": "Wilkowski", "given": "Bartlomiej", "initials": "B"}, {"family": "Larsen", "given": "Nicolai Balle", "initials": "NB"}, {"family": "Legarth", "given": "Rebecca", "initials": "R"}, {"family": "Cohen", "given": "Arieh Sierra", "initials": "AS"}, {"family": "Nielsen", "given": "Finn", "initials": "F"}, {"family": "Lam", "given": "Janni Uyen Hoa", "initials": "JUH"}, {"family": "Lavik", "given": "Kjetil Erdogan", "initials": "KE"}, {"family": "Karakis", "given": "Marianne", "initials": "M"}, {"family": "Spiess", "given": "Katja", "initials": "K"}, {"family": "Marving", "given": "Ellinor", "initials": "E"}, {"family": "Nielsen", "given": "Christian", "initials": "C"}, {"family": "Wiid Svarrer", "given": "Christina", "initials": "C"}, {"family": "Bybjerg-Grauholm", "given": "Jonas", "initials": "J"}, {"family": "Olsen", "given": "Stefan Schytte", "initials": "SS"}, {"family": "Jensen", "given": "Anders", "initials": "A"}, {"family": "Krause", "given": "Tyra Grove", "initials": "TG"}, {"family": "M\u00fcller", "given": "Luise", "initials": "L"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "50", "issn-l": null}, "abstract": "By 9 December 2021, 785 SARS-CoV-2 Omicron variant cases have been identified in Denmark. Most cases were fully (76%) or booster-vaccinated (7.1%); 34 (4.3%) had a previous SARS-CoV-2 infection. The majority of cases with available information reported symptoms (509/666; 76%) and most were infected in Denmark (588/644; 91%). One in five cases cannot be linked to previous cases, indicating widespread community transmission. Nine cases have been hospitalised, one required intensive care and no deaths have been registered.", "doi": "10.2807/1560-7917.ES.2021.26.50.2101146", "pmid": "34915977", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T17:42:47.527Z", "modified": "2021-12-18T17:42:47.539Z"}, {"entity": "publication", "iuid": "ce16ae5550dd4daf93f8efb4d2fe95dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ce16ae5550dd4daf93f8efb4d2fe95dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ce16ae5550dd4daf93f8efb4d2fe95dd"}}, "title": "Digital media content and co-viewing amongst Swedish 4- to 6-year-olds during COVID-19 pandemic.", "authors": [{"family": "Sundqvist", "given": "Annette", "initials": "A", "orcid": "0000-0001-9611-6523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1ee75c32ea3490d9c8f4f8d60c1005a.json"}}, {"family": "Heimann", "given": "Mikael", "initials": "M", "orcid": "0000-0001-5025-9975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58e5802e62bb41f28642119aab148b35.json"}}], "type": "letter", "published": "2021-12-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": "110", "issue": "12", "pages": "3329-3330"}, "abstract": "COVID-19 restrictions have increased the use of digital media and studies have suggested that children's screen time has increased by 10 hours a week since the pandemic.1 However, screen time is a very basic measure and it is also important to consider the content and context of digital media. Digital media may have negative effects on behaviour, language and memory,2,3 but this may be moderated by the positive effects of joint media engagement between children and their parents.", "doi": "10.1111/apa.16090", "pmid": "34469600", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC8653155"}], "notes": [], "created": "2021-09-06T15:53:34.789Z", "modified": "2023-06-19T14:54:35.006Z"}, {"entity": "publication", "iuid": "c42cd7518bcc45228097ec02379a869e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c42cd7518bcc45228097ec02379a869e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c42cd7518bcc45228097ec02379a869e"}}, "title": "Differences in risk for SARS-CoV-2 infection among healthcare workers", "authors": [{"family": "Elfstr\u00f6m", "given": "K Miriam", "initials": "KM"}, {"family": "Blomqvist", "given": "Jonas", "initials": "J"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Pimenoff", "given": "Ville N", "initials": "VN", "orcid": "0000-0002-0813-7031", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6df74f265514d7b8fa216d9bad0ead6.json"}}, {"family": "Arroyo M\u00fchr", "given": "Laila Sara", "initials": "LS"}, {"family": "Lundgren", "given": "Kalle Conneryd", "initials": "KC"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "Prev Med Rep", "issn": "2211-3355", "issn-l": null, "volume": "24", "issue": null, "pages": "101518"}, "abstract": "Healthcare workers (HCWs) are a risk group for SARS-CoV-2 infection, but which healthcare work that conveys risk and to what extent such risk can be prevented is not clear. Starting on April 24th, 2020, all employees at work (n = 15,300) at the Karolinska University Hospital, Stockholm, Sweden were invited and 92% consented to participate in a SARS-CoV-2 cohort study. Complete SARS-CoV-2 serology was available for n = 12,928 employees and seroprevalences were analyzed by age, sex, profession, patient contact, and hospital department. Relative risks were estimated to examine the association between type of hospital department as a proxy for different working environment exposure and risk for seropositivity, adjusting for age, sex, sampling week, and profession. Wards that were primarily responsible for COVID-19 patients were at increased risk (adjusted OR 1.95 (95% CI 1.65-2.32) with the notable exception of the infectious diseases and intensive care units (adjusted OR 0.86 (95% CI 0.66-1.13)), that were not at increased risk despite being highly exposed. Several units with similar types of work varied greatly in seroprevalences. Among the professions examined, nurse assistants had the highest risk (adjusted OR 1.62 (95% CI 1.38-1.90)). Although healthcare workers, in particular nurse assistants, who attend to COVID-19 patients are a risk group for SARS-CoV-2 infection, several units caring for COVID-19 patients had no excess risk. Large variations in seroprevalences among similar units suggest that healthcare work-related risk of SARS-CoV-2 infection may be preventable.", "doi": "10.1016/j.pmedr.2021.101518", "pmid": "34458081", "labels": {"Funder: KAW/SciLifeLab": null, "Category: Health": null, "Research Area: High-throughput and high-content serology": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2211-3355(21)00208-4"}, {"db": "pmc", "key": "PMC8379088"}], "notes": [], "created": "2021-04-10T07:52:23.920Z", "modified": "2022-02-06T17:35:15.389Z"}, {"entity": "publication", "iuid": "da5951f63d5744ed9f8e6bb8a6b7df0c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/da5951f63d5744ed9f8e6bb8a6b7df0c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/da5951f63d5744ed9f8e6bb8a6b7df0c"}}, "title": "Depression, anxiety and suicidal behaviour among college students: Comparisons pre-COVID-19 and during the pandemic.", "authors": [{"family": "McLafferty", "given": "Margaret", "initials": "M"}, {"family": "Brown", "given": "Natasha", "initials": "N"}, {"family": "McHugh", "given": "Rachel", "initials": "R"}, {"family": "Ward", "given": "Caoimhe", "initials": "C"}, {"family": "Stevenson", "given": "Ailis", "initials": "A"}, {"family": "McBride", "given": "Louise", "initials": "L"}, {"family": "Brady", "given": "John", "initials": "J"}, {"family": "Bjourson", "given": "Anthony J", "initials": "AJ"}, {"family": "O'Neill", "given": "Siobhan M", "initials": "SM"}, {"family": "Walsh", "given": "Colum P", "initials": "CP"}, {"family": "Murray", "given": "Elaine K", "initials": "EK"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Psychiatry Res Commun", "issn": "2772-5987", "volume": "1", "issue": "2", "pages": "100012", "issn-l": null}, "abstract": "Many students struggle with psychological problems during their college years. These problems may be even more apparent during the COVID-19 pandemic with the accompanying restrictions and transition to an online learning environment, but few longitudinal studies have been conducted to date. The aim of this study was to compare symptoms of depression, anxiety and suicidality prior to and during the pandemic, and identify stressors.\n\nThis study was conducted among students attending Ulster University, Northern Ireland (NI) and LYIT, Republic of Ireland (ROI), as part of the World Mental Health International College Student Initiative (WMH-ICS). Data was collected from first year students in September 2019. The completed response rate was 25.22% (NI) and 41.9% (ROI) in relation to the number of first-year students registered. A follow up study was conducted in Autumn 2020, with 884 students fully completing the online survey in both years, equating to just under half of those who completed initially.\n\nHigh levels of mental health problems were found in year 1, especially in the ROI. Levels of depression increased significantly in year 2, particularly among students in NI, however, levels of anxiety decreased. No significant variations were found for suicidal behaviour. Several stressors were revealed, including increased social isolation, and worrying about loved ones.\n\nThe findings may not be generalised to other student populations.\n\nThis study reveals variation in symptoms of depression and anxiety since the onset of the pandemic. In particular, the large increase in students with depression is of concern.", "doi": "10.1016/j.psycom.2021.100012", "pmid": "34977911", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2772-5987(21)00012-X"}, {"db": "pmc", "key": "PMC8574925"}], "notes": [], "created": "2022-01-04T14:43:28.782Z", "modified": "2022-01-04T14:43:28.821Z"}, {"entity": "publication", "iuid": "7b60e6c3be494a6c9e59e8b83866fa06", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b60e6c3be494a6c9e59e8b83866fa06.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b60e6c3be494a6c9e59e8b83866fa06"}}, "title": "Clinical outcomes in cancer patients with COVID-19 in Sweden.", "authors": [{"family": "Bondeson", "given": "Lisa", "initials": "L"}, {"family": "Thulin", "given": "Anna", "initials": "A"}, {"family": "Ny", "given": "Lars", "initials": "L", "orcid": "0000-0003-3864-5958", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/861e0a04f51e453ca92d6cca8624e187.json"}}, {"family": "Levin", "given": "Max", "initials": "M"}, {"family": "Svensson", "given": "Johanna", "initials": "J"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Zhao", "given": "Zhiyuan", "initials": "Z", "orcid": "0000-0002-6962-1791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/540e3389bb044d9991e81a68320dd224.json"}}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Acta Oncol", "issn": "1651-226X", "pages": "1572-1579", "volume": "60", "issue": "12", "issn-l": null}, "abstract": "The results of studies on the relationship between cancer and COVID-19 have been conflicting and therefore further studies are needed. We aimed to examine the incidence of COVID-19 among patients at one of the largest oncology departments in Sweden, and to evaluate and identify risk factors for poor outcomes, hospital care and death, associated with COVID-19 among cancer patients.\n\nThis retrospective study included cancer patients at a single center who tested positive for SARS-CoV-2 by PCR either in hospital, primary health care center or commercial laboratory between 1 March and 14 August 2020. Clinical and demographic data were collected from the medical records. Logistic regression analysis was used to identify variables that associated the primary outcomes of need for hospital care and death within 30 days of positive test.\n\nOf 10,774 patients from the Department of Oncology at Sahlgrenska University Hospital, 135 tested positive for SARS-CoV-2 (1.3%). Twenty-eight patients were excluded from further the data collection since they did not meet the inclusion criteria. Altogether, 107 cancer patients were included and the case fatality rate (CFR) was 12% (13) within 30 days of confirmed SARS-CoV-2 infection by PCR. Increasing years of age (OR 1.10; CI 95% 1.03-1.18), palliative treatment intent (OR 15.7; CI 95% 1.8-135.8), and transition to end-of-life care (OR 52.0; CI 95% 3.7-735.6) were associated with increased odds of death within 30 days. Male sex was associated with needing hospital care (OR 3.7; CI 95% 1.50-9.1).\n\nAs in the general population, male sex was found to be at greater risk of needing hospital care for COVID-19, with terminal cancer disease, and older age increasing the odds of fatality. Compared to the general population, slightly more cancer patients had COVID-19. The CFR was within the lower range of others reported in cancer patients.", "doi": "10.1080/0284186X.2021.1973679", "pmid": "34530692", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-09-20T16:54:02.162Z", "modified": "2023-01-13T13:30:58.420Z"}, {"entity": "publication", "iuid": "cad95e26023141d3a2014a198a44eea6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cad95e26023141d3a2014a198a44eea6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cad95e26023141d3a2014a198a44eea6"}}, "title": "Characteristics and definitive outcomes of COVID-19 patients admitted to a secondary hospital intensive care unit in Sweden.", "authors": [{"family": "Sj\u00f6str\u00f6m", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-5671-2563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7135a88659334a8eba1250f0caa3941c.json"}}, {"family": "M\u00e5nsson", "given": "Emeli", "initials": "E"}, {"family": "Viklund Kamienny", "given": "Josefin", "initials": "J"}, {"family": "\u00d6stberg", "given": "Erland", "initials": "E"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Health Sci Rep", "issn": "2398-8835", "volume": "4", "issue": "4", "pages": "e446", "issn-l": null}, "abstract": "Most published reports of COVID-19 Intensive Care Unit (ICU) patients are from large tertiary hospitals and often present short-term or incomplete outcome data. There are reports indicating that ICUs with fewer beds are associated with higher mortality. This study aimed to investigate the definitive outcome and patient characteristics of the complete first wave of COVID-19 patients admitted to ICU in a secondary hospital.\n\nIn this prospective observational study, all patients with respiratory failure and a positive SARS-CoV-2 test admitted to V\u00e4ster\u00e5s Hospital ICU between 24 March and July 22, 2020 were included. The primary outcome was defined as 90-day mortality. Secondary outcomes included ICU length of stay, hospital length of stay, number of days with invasive ventilation, need for vasopressors/inotropes, and use of renal replacement therapy.\n\nFifty-three patients were included. Median age (range) was 59 (33-76) and 74% were men. Obesity and hypertension were the most common comorbidities and 45% of the patients were born outside Europe. Ninety-day mortality was 30%. Median ICU length of stay (interquartile range) was 14 (5-24) days and the duration of invasive mechanical ventilation 16 (12-26) days. No patients received dialysis at 90-day follow-up.\n\nIn this cohort of COVID-19 patients treated in a secondary hospital ICU, mortality rates were low compared to early studies from China, Italy, and the United States, but similar to other government-funded hospitals in Scandinavia. A preparatory reorganization enabled an increase in ICU capacity, hence avoiding an overwhelmed intensive care organization.", "doi": "10.1002/hsr2.446", "pmid": "34938894", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "HSR2446"}, {"db": "pmc", "key": "PMC8670731"}], "notes": [], "created": "2022-01-03T15:34:46.050Z", "modified": "2022-01-03T15:34:46.133Z"}, {"entity": "publication", "iuid": "34c0583ae1ea4e0c83bb5bac2f979093", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/34c0583ae1ea4e0c83bb5bac2f979093.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/34c0583ae1ea4e0c83bb5bac2f979093"}}, "title": "COVID-19 trends and severity among symptomatic children aged 0-17 years in 10 European Union countries, 3 August 2020 to 3 October 2021.", "authors": [{"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Dave", "given": "Nishi", "initials": "N"}, {"family": "Pharris", "given": "Anastasia", "initials": "A"}, {"family": "Spiteri", "given": "Gianfranco", "initials": "G"}, {"family": "Deogan", "given": "Charlotte", "initials": "C"}, {"family": "Suk", "given": "Jonathan E", "initials": "JE"}, {"family": "Study group members", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "50", "issn-l": null}, "abstract": "We estimated risks of severe outcomes in 820,404 symptomatic paediatric COVID-19 cases reported by 10 European Union countries between August 2020 and October 2021. Case and hospitalisation rates rose as transmission increased but severe outcomes were rare: 9,611 (1.2%) were hospitalised, 640 (0.08%) required intensive care and 84 (0.01%) died. Despite increased individual risk (adjusted odds ratio hospitalisation: 7.3; 95% confidence interval: 3.3-16.2; intensive care: 8.7; 6.2-12.3) in cases with comorbidities, most (83.7%) hospitalised children had no comorbidity.", "doi": "10.2807/1560-7917.ES.2021.26.50.2101098", "pmid": "34915968", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T17:44:33.895Z", "modified": "2021-12-18T17:44:33.907Z"}, {"entity": "publication", "iuid": "09c78ca7f2f44a6f8173de8e305a5ff5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/09c78ca7f2f44a6f8173de8e305a5ff5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/09c78ca7f2f44a6f8173de8e305a5ff5"}}, "title": "COVID-19 is Associated with an Acquired Factor XIII Deficiency.", "authors": [{"family": "von Meijenfeldt", "given": "Fien A", "initials": "FA"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Adelmeijer", "given": "Jelle", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Thalin", "given": "Charlotte", "initials": "C"}, {"family": "Lisman", "given": "Ton", "initials": "T"}], "type": "letter", "published": "2021-12-00", "journal": {"title": "Thromb Haemost", "issn": "2567-689X", "issn-l": "0340-6245", "volume": "121", "issue": "12", "pages": "1668-1669"}, "abstract": "No Abstract.", "doi": "10.1055/a-1450-8414", "pmid": "33742434", "labels": {"Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-22T10:28:03.488Z", "modified": "2022-02-06T17:15:14.074Z"}, {"entity": "publication", "iuid": "ac5fb4e2b68f4c5b8ee3a19341e6f046", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac5fb4e2b68f4c5b8ee3a19341e6f046.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac5fb4e2b68f4c5b8ee3a19341e6f046"}}, "title": "Asthma Diagnosis without Aerosol-Generating Procedures (Spirometry): Evidence for and Beyond the COVID-19 Pandemic", "authors": [{"family": "Kankaanranta", "given": "Hannu", "initials": "H"}, {"family": "Lehtim\u00e4ki", "given": "Lauri", "initials": "L"}, {"family": "Tuomisto", "given": "Leena E", "initials": "LE"}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "The Journal of Allergy and Clinical Immunology: In Practice", "issn": "2213-2198", "volume": "9", "issue": "12", "pages": "4252-4253", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jaip.2021.09.036", "pmid": null, "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:45:57.547Z", "modified": "2021-12-12T06:45:57.570Z"}, {"entity": "publication", "iuid": "460adc71009e4637b23139398f8c251a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/460adc71009e4637b23139398f8c251a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/460adc71009e4637b23139398f8c251a"}}, "title": "Appendicitis as a possible safety signal for the COVID-19 vaccines.", "authors": [{"family": "Mitchell", "given": "Joseph", "initials": "J"}, {"family": "Yue", "given": "Qun-Ying", "initials": "QY"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Vaccine X", "issn": "2590-1362", "volume": "9", "pages": "100122", "issn-l": null}, "abstract": "This study reviewed cases of appendicitis following administration of COVID-19 vaccines reported to VigiBase, the WHO database of individual case safety reports (ICSRs). Three hundred fifty-eight cases were identified, and disproportionate reporting was noted, with 329 calculated expected cases. Upon review, 24 ICSRs were excluded, so 334 unique ICSRs underwent clinical review from 19 countries. Forty-eight percent of ICSRs reported imaging and 69% noted surgical intervention. The cases were clinically coherent, with an apparent increase in reporting in the four days post-vaccination and a possible dose-response relationship. Appendicitis has been suggested as an adverse event of special interest post-vaccination against COVID-19 after a numerical increase in the vaccine arm of a clinical trial. The case series may be affected by differences in global patterns of reporting, and it is not possible to prove nor disprove causality from this case series. Global longitudinal studies are required to clarify any possible relationship.", "doi": "10.1016/j.jvacx.2021.100122", "pmid": "34746743", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2590-1362(21)00039-5"}, {"db": "pmc", "key": "PMC8565092"}], "notes": [], "created": "2021-11-26T15:34:13.902Z", "modified": "2021-11-26T15:34:26.952Z"}, {"entity": "publication", "iuid": "f7fbe5dff8494271a1aacb6195cf6751", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7fbe5dff8494271a1aacb6195cf6751.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7fbe5dff8494271a1aacb6195cf6751"}}, "title": "Angiotensin-Converting Enzyme 2 (SARS-CoV-2 receptor) expression in human skeletal muscle.", "authors": [{"family": "Perez-Valera", "given": "Mario", "initials": "M", "orcid": "0000-0002-8332-729X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35803b8f85964ce29760fbfad3aa06ac.json"}}, {"family": "Martinez-Canton", "given": "Miriam", "initials": "M", "orcid": "0000-0002-2925-3429", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77d454baf0894523ba5bc199eab7f95a.json"}}, {"family": "Gallego-Selles", "given": "Angel", "initials": "A", "orcid": "0000-0002-8068-9586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70d49ae713f2483fa618b92fbf1588d1.json"}}, {"family": "Galv\u00e1n-Alvarez", "given": "Victor", "initials": "V", "orcid": "0000-0002-1272-3471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f1c4f6e96b34be0a806da80c295efec.json"}}, {"family": "Gelabert-Rebato", "given": "Miriam", "initials": "M", "orcid": "0000-0002-8963-5568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0a3ce72669b4327b37c5a50bfc4e063.json"}}, {"family": "Morales-Alamo", "given": "David", "initials": "D", "orcid": "0000-0001-8463-397X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b9030289cfc412eb3ad0520a4f415fb.json"}}, {"family": "Santana", "given": "Alfredo", "initials": "A"}, {"family": "Martin-Rodriguez", "given": "Saul", "initials": "S", "orcid": "0000-0003-2423-5309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b26c4d0d7634deaa6a8869f40782e01.json"}}, {"family": "Ponce-Gonzalez", "given": "Jesus Gustavo", "initials": "JG", "orcid": "0000-0002-5982-7761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a276f5133dcc4bebb7bfae3939dd8f1b.json"}}, {"family": "Larsen", "given": "Steen", "initials": "S", "orcid": "0000-0002-5170-4337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c7e2c4f43b74b5ea6a52ec74ebb67ac.json"}}, {"family": "Losa-Reyna", "given": "Jose", "initials": "J", "orcid": "0000-0001-9545-5654", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/811b803c1ee749868f4b8ef94c82ded2.json"}}, {"family": "Perez-Suarez", "given": "Ismael", "initials": "I", "orcid": "0000-0002-7969-0061", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1ee30dc71c947028d55aecb45de60f3.json"}}, {"family": "Dorado", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-6616-6810", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db7e83e02066409988f34726d87735c5.json"}}, {"family": "Curtelin", "given": "David", "initials": "D", "orcid": "0000-0001-6462-382X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b9aecb9e275413a93fb0fc49b9198e6.json"}}, {"family": "Gonzalez-Henriquez", "given": "Juan Jose", "initials": "JJ", "orcid": "0000-0002-0622-5580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f66fd2bee3cd4391b23f6cba17aa7af3.json"}}, {"family": "Boushel", "given": "Robert", "initials": "R"}, {"family": "Hallen", "given": "Jostein", "initials": "J", "orcid": "0000-0002-6646-0734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8ad3bb0c71742dd95d6c584dc484254.json"}}, {"family": "de Pablos Velasco", "given": "Pedro", "initials": "P", "orcid": "0000-0002-9190-2581", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/951391585db9407bb6e42de7edb31c54.json"}}, {"family": "Freixinet-Gilart", "given": "Jorge", "initials": "J"}, {"family": "Holmberg", "given": "Hans-Christer", "initials": "HC", "orcid": "0000-0002-3814-6246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6325cd0a9474be49df847f6677f96bb.json"}}, {"family": "Helge", "given": "Jorn W", "initials": "JW", "orcid": "0000-0001-9724-5423", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0080b3aa65ce4d879c8c9c10e68b8d80.json"}}, {"family": "Martin-Rincon", "given": "Marcos", "initials": "M", "orcid": "0000-0002-3685-2331", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a26c0e8c2de4c07af458b07036369b4.json"}}, {"family": "Calbet", "given": "Jose A L", "initials": "JAL", "orcid": "0000-0002-9215-6234", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef57535cde26435ab75c47827f26bc48.json"}}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Scand J Med Sci Sports", "issn": "1600-0838", "issn-l": null, "volume": "31", "issue": "12", "pages": "2249-2258"}, "abstract": "The study aimed to determine the levels of skeletal muscle angiotensin-converting enzyme 2 (ACE2, the SARS-CoV-2 receptor) protein expression in men and women and assess whether ACE2 expression in skeletal muscle is associated with cardiorespiratory fitness and adiposity. The level of ACE2 in vastus lateralis muscle biopsies collected in previous studies from 170 men (age: 19-65 years, weight: 56-137 kg, BMI: 23-44) and 69 women (age: 18-55 years, weight: 41-126 kg, BMI: 22-39) was analyzed in duplicate by western blot. VO2 max was determined by ergospirometry and body composition by DXA. ACE2 protein expression was 1.8-fold higher in women than men (p = 0.001, n = 239). This sex difference disappeared after accounting for the percentage of body fat (fat %), VO2 max per kg of legs lean mass (VO2 max-LLM) and age (p = 0.47). Multiple regression analysis showed that the fat % (\u03b2 = 0.47) is the main predictor of the variability in ACE2 protein expression in skeletal muscle, explaining 5.2% of the variance. VO2 max-LLM had also predictive value (\u03b2 = 0.09). There was a significant fat % by VO2 max-LLM interaction, such that for subjects with low fat %, VO2 max-LLM was positively associated with ACE2 expression while as fat % increased the slope of the positive association between VO2 max-LLM and ACE2 was reduced. In conclusion, women express higher amounts of ACE2 in their skeletal muscles than men. This sexual dimorphism is mainly explained by sex differences in fat % and cardiorespiratory fitness. The percentage of body fat is the main predictor of the variability in ACE2 protein expression in human skeletal muscle.", "doi": "10.1111/sms.14061", "pmid": "34551157", "labels": {"Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8662278"}], "notes": [], "created": "2021-10-27T05:14:42.763Z", "modified": "2023-06-19T14:55:14.813Z"}, {"entity": "publication", "iuid": "efe78cba12754f37bbd373087552168b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/efe78cba12754f37bbd373087552168b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/efe78cba12754f37bbd373087552168b"}}, "title": "Alcohol consumption during the COVID-19 pandemic in Europe: a large-scale cross-sectional study in 21 countries.", "authors": [{"family": "Kilian", "given": "Carolin", "initials": "C", "orcid": "0000-0001-5913-6488", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed0409bb90b346cd9001bebb46bdcf87.json"}}, {"family": "Rehm", "given": "J\u00fcrgen", "initials": "J", "orcid": "0000-0001-5665-0385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83f5b8ddf5844eb6a1118d8ec4c4dca2.json"}}, {"family": "Allebeck", "given": "Peter", "initials": "P", "orcid": "0000-0002-2778-6467", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de9f0e1c3e4d402b93e61ad1c5a771fb.json"}}, {"family": "Braddick", "given": "Fleur", "initials": "F", "orcid": "0000-0001-6755-4567", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e9df2867269470ab43dd6802b5abb49.json"}}, {"family": "Gual", "given": "Antoni", "initials": "A", "orcid": "0000-0002-7130-981X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a9b53e2b8644056920e73b5b1d014d9.json"}}, {"family": "Bart\u00e1k", "given": "Miroslav", "initials": "M", "orcid": "0000-0002-7265-6514", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77e98268e4ef42f6a5a036b75d6a1c56.json"}}, {"family": "Bloomfield", "given": "Kim", "initials": "K", "orcid": "0000-0002-9740-126X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/17159b4979b74d4b81543e53c1e339ef.json"}}, {"family": "Gil", "given": "Artyom", "initials": "A", "orcid": "0000-0002-0548-5380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a39dedff1af2460a9053e78804085087.json"}}, {"family": "Neufeld", "given": "Maria", "initials": "M", "orcid": "0000-0001-6364-3765", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/641c0a90ba5c41ab904f9d1b8212b387.json"}}, {"family": "O'Donnell", "given": "Amy", "initials": "A", "orcid": "0000-0003-4071-9434", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ae93b46570e4fe092eb0dde1bf3edae.json"}}, {"family": "Petru\u017eelka", "given": "Benjamin", "initials": "B", "orcid": "0000-0003-0318-3589", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/135b991aff2a486cb76a4f362d85b5e6.json"}}, {"family": "Rogalewicz", "given": "Vladimir", "initials": "V", "orcid": "0000-0001-5432-4148", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/904dc3953e4e42d4ac5f317f7b3c5b36.json"}}, {"family": "Schulte", "given": "Bernd", "initials": "B", "orcid": "0000-0003-1139-030X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79c126298bdf42518d5d0384a7e1ec42.json"}}, {"family": "Manthey", "given": "Jakob", "initials": "J", "orcid": "0000-0003-1231-3760", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5e779db5bf14c38aad0f3a964b7d9bd.json"}}, {"family": "European Study Group on Alcohol Use and COVID-19", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Addiction", "issn": "1360-0443", "issn-l": null, "volume": "116", "issue": "12", "pages": "3369-3380"}, "abstract": "To investigate changes in alcohol consumption during the first months of the COVID-19 pandemic in Europe as well as its associations with income and experiences of distress related to the pandemic.\n\nCross-sectional on-line survey conducted between 24 April and 22 July 2020.\n\nTwenty-one European countries.\n\nA total of 31 964 adults reporting past-year drinking.\n\nChanges in alcohol consumption were measured by asking respondents about changes over the previous month in their drinking frequency, the quantity they consumed and incidence of heavy episodic drinking events. Individual indicators were combined into an aggregated consumption-change score and scaled to a possible range of -1 to +1. Using this score as the outcome, multi-level linear regressions tested changes in overall drinking, taking into account sampling weights and baseline alcohol consumption [Alcohol Use Disorder Identification Test (AUDIT-C)] and country of residence serving as random intercept. Similar models were conducted for each single consumption-change indicator.\n\nThe aggregated consumption-change score indicated an average decrease in alcohol consumption of -0.14 [95% confidence interval (CI) = -0.18, -0.10]. Statistically significant decreases in consumption were found in all countries, except Ireland (-0.08, 95% CI = -0.17, 0.01) and the United Kingdom (+0.10, 95% CI = 0.03, 0.17). Decreases in drinking were mainly driven by a reduced frequency of heavy episodic drinking events (-0.17, 95% CI = -0.20, -0.14). Declines in consumption were less marked among those with low- or average incomes and those experiencing distress.\n\nOn average, alcohol consumption appears to have declined during the first months of the COVID-19 pandemic in Europe. Both reduced availability of alcohol and increased distress may have affected consumption, although the former seems to have had a greater impact in terms of immediate effects.", "doi": "10.1111/add.15530", "pmid": "34109685", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-11T05:05:21.772Z", "modified": "2023-06-19T07:32:42.997Z"}, {"entity": "publication", "iuid": "196bb322291948ddb3242acd3929326f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/196bb322291948ddb3242acd3929326f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/196bb322291948ddb3242acd3929326f"}}, "title": "Acquired olfactory loss alters functional connectivity and morphology", "authors": [{"family": "Iravani", "given": "Behzad", "initials": "B"}, {"family": "Peter", "given": "Moa G", "initials": "MG"}, {"family": "Arshamian", "given": "Artin", "initials": "A"}, {"family": "Olsson", "given": "Mats J", "initials": "MJ"}, {"family": "Hummel", "given": "Thomas", "initials": "T"}, {"family": "Kitzler", "given": "Hagen H", "initials": "HH"}, {"family": "Lundstr\u00f6m", "given": "Johan N", "initials": "JN"}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": null}, "abstract": null, "doi": "10.1038/s41598-021-95968-7", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-15T15:48:22.155Z", "modified": "2022-07-06T06:58:18.400Z"}, {"entity": "publication", "iuid": "15f52e9d5ead4387aae6b6cd95392dae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15f52e9d5ead4387aae6b6cd95392dae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15f52e9d5ead4387aae6b6cd95392dae"}}, "title": "A population-based dataset concerning predictors of willingness to get a COVID-19 vaccine in Iran.", "authors": [{"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}, {"family": "Yahaghi", "given": "Rafat", "initials": "R"}, {"family": "Ahmadizade", "given": "Safie", "initials": "S"}, {"family": "Fotuhi", "given": "Razie", "initials": "R"}, {"family": "Taherkhani", "given": "Elham", "initials": "E"}, {"family": "Ranjbaran", "given": "Mehdi", "initials": "M"}, {"family": "Buchali", "given": "Zeinab", "initials": "Z"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Data Brief", "issn": "2352-3409", "issn-l": null, "volume": "39", "issue": null, "pages": "107459"}, "abstract": "The global issue of preventing the spread of COVID-19 is challenging. One of the most efficient ways to control the pandemic is to have a full coverage of COVID-19 vaccination. Therefore, this paper collected survey data to understand the intention and willingness of COVID-19 vaccination uptake in Qazvin, Iran. With the use of a paper-and-pencil method and multistage stratified cluster sampling, research personnel approached and interviewed a representative sample of adults in Qazvin (n = 10843) between February 19 and April 9, 2021. The survey asked questions regarding sociodemographic information, fear of COVID-19, perceived COVID-19 infectability, perceived behavioral control over COVID-19 vaccination, subjective norm of COVID-19 vaccination, attitude towards COVID-19 vaccination, and intention to get COVID-19 vaccinated. The data collected from this survey were analyzed using descriptive statistics, which were carried out using the IBM SPSS version 17.0.", "doi": "10.1016/j.dib.2021.107459", "pmid": "34660863", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC8500683"}, {"db": "pii", "key": "S2352-3409(21)00741-1"}], "notes": [], "created": "2021-10-21T05:00:29.137Z", "modified": "2023-06-19T15:21:28.910Z"}, {"entity": "publication", "iuid": "5209cda5a4434416b9a275a6087f708e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5209cda5a4434416b9a275a6087f708e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5209cda5a4434416b9a275a6087f708e"}}, "title": "A global observational analysis to understand changes in air quality during exceptionally low anthropogenic emission conditions", "authors": [{"family": "Sokhi", "given": "Ranjeet S", "initials": "RS"}, {"family": "Singh", "given": "Vikas", "initials": "V"}, {"family": "Querol", "given": "Xavier", "initials": "X"}, {"family": "Finardi", "given": "Sandro", "initials": "S"}, {"family": "Targino", "given": "Admir Cr\u00e9so", "initials": "AC"}, {"family": "Andrade", "given": "Maria de Fatima", "initials": "MdF"}, {"family": "Pavlovic", "given": "Radenko", "initials": "R"}, {"family": "Garland", "given": "Rebecca M", "initials": "RM"}, {"family": "Massagu\u00e9", "given": "Jordi", "initials": "J"}, {"family": "Kong", "given": "Shaofei", "initials": "S"}, {"family": "Baklanov", "given": "Alexander", "initials": "A"}, {"family": "Ren", "given": "Lu", "initials": "L"}, {"family": "Tarasova", "given": "Oksana", "initials": "O"}, {"family": "Carmichael", "given": "Greg", "initials": "G"}, {"family": "Peuch", "given": "Vincent Henri", "initials": "VH"}, {"family": "Anand", "given": "Vrinda", "initials": "V"}, {"family": "Arbilla", "given": "Graciela", "initials": "G"}, {"family": "Badali", "given": "Kaitlin", "initials": "K"}, {"family": "Beig", "given": "Gufran", "initials": "G"}, {"family": "Belalcazar", "given": "Luis Carlos", "initials": "LC"}, {"family": "Bolignano", "given": "Andrea", "initials": "A"}, {"family": "Brimblecombe", "given": "Peter", "initials": "P"}, {"family": "Camacho", "given": "Patricia", "initials": "P"}, {"family": "Casallas", "given": "Alejandro", "initials": "A"}, {"family": "Charland", "given": "Jean Pierre", "initials": "JP"}, {"family": "Choi", "given": "Jason", "initials": "J"}, {"family": "Chourdakis", "given": "Eleftherios", "initials": "E"}, {"family": "Coll", "given": "Isabelle", "initials": "I"}, {"family": "Collins", "given": "Marty", "initials": "M"}, {"family": "Cyrys", "given": "Josef", "initials": "J"}, {"family": "da Silva", "given": "Cleyton Martins", "initials": "CM"}, {"family": "Di Giosa", "given": "Alessandro Domenico", "initials": "AD"}, {"family": "Di Leo", "given": "Anna", "initials": "A"}, {"family": "Ferro", "given": "Camilo", "initials": "C"}, {"family": "Gavidia-Calderon", "given": "Mario", "initials": "M"}, {"family": "Gayen", "given": "Amiya", "initials": "A"}, {"family": "Ginzburg", "given": "Alexander", "initials": "A"}, {"family": "Godefroy", "given": "Fabrice", "initials": "F"}, {"family": "Gonzalez", "given": "Yuri Alexandra", "initials": "YA"}, {"family": "Guevara-Luna", "given": "Marco", "initials": "M"}, {"family": "Haque", "given": "Sk Mafizul", "initials": "SM"}, {"family": "Havenga", "given": "Henno", "initials": "H"}, {"family": "Herod", "given": "Dennis", "initials": "D"}, {"family": "H\u00f5rrak", "given": "Urmas", "initials": "U"}, {"family": "Hussein", "given": "Tareq", "initials": "T"}, {"family": "Ibarra", "given": "Sergio", "initials": "S"}, {"family": "Jaimes", "given": "Monica", "initials": "M"}, {"family": "Kaasik", "given": "Marko", "initials": "M"}, {"family": "Khaiwal", "given": "Ravindra", "initials": "R"}, {"family": "Kim", "given": "Jhoon", "initials": "J"}, {"family": "Kousa", "given": "Anu", "initials": "A"}, {"family": "Kukkonen", "given": "Jaakko", "initials": "J"}, {"family": "Kulmala", "given": "Markku", "initials": "M"}, {"family": "Kuula", "given": "Joel", "initials": "J"}, {"family": "La Violette", "given": "Nathalie", "initials": "N"}, {"family": "Lanzani", "given": "Guido", "initials": "G"}, {"family": "Liu", "given": "Xi", "initials": "X"}, {"family": "MacDougall", "given": "Stephanie", "initials": "S"}, {"family": "Manseau", "given": "Patrick M", "initials": "PM"}, {"family": "Marchegiani", "given": "Giada", "initials": "G"}, {"family": "McDonald", "given": "Brian", "initials": "B"}, {"family": "Mishra", "given": "Swasti Vardhan", "initials": "SV"}, {"family": "Molina", "given": "Luisa T", "initials": "LT"}, {"family": "Mooibroek", "given": "Dennis", "initials": "D"}, {"family": "Mor", "given": "Suman", "initials": "S"}, {"family": "Moussiopoulos", "given": "Nicolas", "initials": "N"}, {"family": "Murena", "given": "Fabio", "initials": "F"}, {"family": "Niemi", "given": "Jarkko V", "initials": "JV"}, {"family": "Noe", "given": "Steffen", "initials": "S"}, {"family": "Nogueira", "given": "Thiago", "initials": "T"}, {"family": "Norman", "given": "Michael", "initials": "M"}, {"family": "P\u00e9rez-Cama\u00f1o", "given": "Juan Luis", "initials": "JL"}, {"family": "Pet\u00e4j\u00e4", "given": "Tuukka", "initials": "T"}, {"family": "Piketh", "given": "Stuart", "initials": "S"}, {"family": "Rathod", "given": "Aditi", "initials": "A"}, {"family": "Reid", "given": "Ken", "initials": "K"}, {"family": "Retama", "given": "Armando", "initials": "A"}, {"family": "Rivera", "given": "Olivia", "initials": "O"}, {"family": "Rojas", "given": "N\u00e9stor Y", "initials": "NY"}, {"family": "Rojas-Quincho", "given": "Jhojan P", "initials": "JP"}, {"family": "San Jos\u00e9", "given": "Roberto", "initials": "R"}, {"family": "S\u00e1nchez", "given": "Od\u00f3n", "initials": "O"}, {"family": "Seguel", "given": "Rodrigo J", "initials": "RJ"}, {"family": "Sillanp\u00e4\u00e4", "given": "Salla", "initials": "S"}, {"family": "Su", "given": "Yushan", "initials": "Y"}, {"family": "Tapper", "given": "Nigel", "initials": "N"}, {"family": "Terrazas", "given": "Antonio", "initials": "A"}, {"family": "Timonen", "given": "Hilkka", "initials": "H"}, {"family": "Toscano", "given": "Domenico", "initials": "D"}, {"family": "Tsegas", "given": "George", "initials": "G"}, {"family": "Velders", "given": "Guus J M", "initials": "GJM"}, {"family": "Vlachokostas", "given": "Christos", "initials": "C"}, {"family": "von Schneidemesser", "given": "Erika", "initials": "E"}, {"family": "VPM", "given": "Rajasree", "initials": "R"}, {"family": "Yadav", "given": "Ravi", "initials": "R"}, {"family": "Zalakeviciute", "given": "Rasa", "initials": "R"}, {"family": "Zavala", "given": "Miguel", "initials": "M"}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "Environ Int", "issn": "0160-4120", "volume": "157", "pages": "106818", "issn-l": null}, "abstract": null, "doi": "10.1016/j.envint.2021.106818", "pmid": null, "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-27T09:40:05.202Z", "modified": "2021-08-27T09:40:05.218Z"}, {"entity": "publication", "iuid": "2d92617b4d3e42e2beca4d29d9785cba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d92617b4d3e42e2beca4d29d9785cba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d92617b4d3e42e2beca4d29d9785cba"}}, "title": "A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome: No Evidence of Benefit, Supported by Epidemiology and In Vitro Data", "authors": [{"family": "Wel\u00e9n", "given": "Karin", "initials": "K"}, {"family": "Rosendal", "given": "Ebba", "initials": "E"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Lenman", "given": "Annasara", "initials": "A"}, {"family": "Freyhult", "given": "Eva", "initials": "E"}, {"family": "Fonseca-Rodr\u00edguez", "given": "Osvaldo", "initials": "O"}, {"family": "Bremell", "given": "Daniel", "initials": "D"}, {"family": "Stranne", "given": "Johan", "initials": "J"}, {"family": "Balkhed", "given": "\u00c5se \u00d6stholm", "initials": "\u00c5\u00d6"}, {"family": "Niward", "given": "Katarina", "initials": "K"}, {"family": "Repo", "given": "Johanna", "initials": "J"}, {"family": "Robinsson", "given": "David", "initials": "D"}, {"family": "Henningsson", "given": "Anna J", "initials": "AJ"}, {"family": "Styrke", "given": "Johan", "initials": "J"}, {"family": "Angelin", "given": "Martin", "initials": "M"}, {"family": "Lindquist", "given": "Elisabeth", "initials": "E"}, {"family": "Allard", "given": "Annika", "initials": "A"}, {"family": "Becker", "given": "Miriam", "initials": "M"}, {"family": "Rudolfsson", "given": "Stina", "initials": "S"}, {"family": "Buckland", "given": "Robert", "initials": "R"}, {"family": "Carlsson", "given": "Camilla Thellenberg", "initials": "CT"}, {"family": "Bjartell", "given": "Anders", "initials": "A"}, {"family": "Nilsson", "given": "Anna C", "initials": "AC"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Connolly", "given": "Anne Marie Fors", "initials": "AMF"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "Josefsson", "given": "Andreas", "initials": "A"}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "European Urology", "issn": "0302-2838", "issn-l": null}, "abstract": null, "doi": "10.1016/j.eururo.2021.12.013", "pmid": "34980495", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T14:42:26.854Z", "modified": "2022-01-10T15:43:27.765Z"}, {"entity": "publication", "iuid": "d14b85b93cb844bcbed101295548421f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d14b85b93cb844bcbed101295548421f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d14b85b93cb844bcbed101295548421f"}}, "title": "Unsuccessful and Successful Clinical Trials in Acute Respiratory Distress Syndrome: Addressing Physiology-Based Gaps.", "authors": [{"family": "Villar", "given": "Jes\u00fas", "initials": "J"}, {"family": "Ferrando", "given": "Carlos", "initials": "C"}, {"family": "Tusman", "given": "Gerardo", "initials": "G"}, {"family": "Berra", "given": "Lorenzo", "initials": "L"}, {"family": "Rodr\u00edguez-Su\u00e1rez", "given": "Pedro", "initials": "P"}, {"family": "Su\u00e1rez-Sipmann", "given": "Fernando", "initials": "F"}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "Front Physiol", "issn": "1664-042X", "volume": "12", "pages": "774025", "issn-l": null}, "abstract": "The acute respiratory distress syndrome (ARDS) is a severe form of acute hypoxemic respiratory failure caused by an insult to the alveolar-capillary membrane, resulting in a marked reduction of aerated alveoli, increased vascular permeability and subsequent interstitial and alveolar pulmonary edema, reduced lung compliance, increase of physiological dead space, and hypoxemia. Most ARDS patients improve their systemic oxygenation, as assessed by the ratio between arterial partial pressure of oxygen and inspired oxygen fraction, with conventional intensive care and the application of moderate-to-high levels of positive end-expiratory pressure. However, in some patients hypoxemia persisted because the lungs are markedly injured, remaining unresponsive to increasing the inspiratory fraction of oxygen and positive end-expiratory pressure. For decades, mechanical ventilation was the only standard support technique to provide acceptable oxygenation and carbon dioxide removal. Mechanical ventilation provides time for the specific therapy to reverse the disease-causing lung injury and for the recovery of the respiratory function. The adverse effects of mechanical ventilation are direct consequences of the changes in pulmonary airway pressures and intrathoracic volume changes induced by the repetitive mechanical cycles in a diseased lung. In this article, we review 14 major successful and unsuccessful randomized controlled trials conducted in patients with ARDS on a series of techniques to improve oxygenation and ventilation published since 2010. Those trials tested the effects of adjunctive therapies (neuromuscular blocking agents, prone positioning), methods for selecting the optimum positive end-expiratory pressure (after recruitment maneuvers, or guided by esophageal pressure), high-frequency oscillatory ventilation, extracorporeal oxygenation, and pharmacologic immune modulators of the pulmonary and systemic inflammatory responses in patients affected by ARDS. We will briefly comment physiology-based gaps of negative trials and highlight the possible needs to address in future clinical trials in ARDS.", "doi": "10.3389/fphys.2021.774025", "pmid": "34916959", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8669801"}], "notes": [], "created": "2021-12-18T17:42:17.076Z", "modified": "2021-12-18T17:42:17.088Z"}, {"entity": "publication", "iuid": "acb0b2a3a77b41a6b28110c03160a6b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/acb0b2a3a77b41a6b28110c03160a6b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/acb0b2a3a77b41a6b28110c03160a6b4"}}, "title": "The effects of different travel modes and travel destinations on COVID-19 transmission in global cities.", "authors": [{"family": "Zhu", "given": "Rui", "initials": "R"}, {"family": "Anselin", "given": "Luc", "initials": "L"}, {"family": "Batty", "given": "Michael", "initials": "M"}, {"family": "Kwan", "given": "Mei-Po", "initials": "MP"}, {"family": "Chen", "given": "Min", "initials": "M"}, {"family": "Luo", "given": "Wei", "initials": "W"}, {"family": "Cheng", "given": "Tao", "initials": "T"}, {"family": "Lim", "given": "Che Kang", "initials": "CK"}, {"family": "Santi", "given": "Paolo", "initials": "P"}, {"family": "Cheng", "given": "Cheng", "initials": "C"}, {"family": "Gu", "given": "Qiushi", "initials": "Q"}, {"family": "Wong", "given": "Man Sing", "initials": "MS"}, {"family": "Zhang", "given": "Kai", "initials": "K"}, {"family": "L\u00fc", "given": "Guonian", "initials": "G"}, {"family": "Ratti", "given": "Carlo", "initials": "C"}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "Sci Bull (Beijing)", "issn": "2095-9273", "issn-l": null}, "abstract": null, "doi": "10.1016/j.scib.2021.11.023", "pmid": "34868708", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2095-9273(21)00731-3"}, {"db": "pmc", "key": "PMC8631046"}], "notes": [], "created": "2021-12-12T07:08:23.462Z", "modified": "2021-12-12T07:09:00.122Z"}, {"entity": "publication", "iuid": "df7653ff47fd45239730fb0c6777cc43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/df7653ff47fd45239730fb0c6777cc43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/df7653ff47fd45239730fb0c6777cc43"}}, "title": "Epidemiology and factors associated with COVID-19 outbreak-related deaths in patients admitted to medical centers of Mazandaran University of Medical Sciences.", "authors": [{"family": "Khankeh", "given": "Hamidreza", "initials": "H"}, {"family": "Farrokhi", "given": "Mehrdad", "initials": "M"}, {"family": "Ghadicolaei", "given": "Hassan Talebi", "initials": "HT"}, {"family": "Mazhin", "given": "Sadegh Ahmadi", "initials": "SA"}, {"family": "Roudini", "given": "Juliet", "initials": "J"}, {"family": "Mohsenzadeh", "given": "Yazdan", "initials": "Y"}, {"family": "Hadinejad", "given": "Zoya", "initials": "Z"}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "J Educ Health Promot", "issn": "2277-9531", "volume": "10", "pages": "426", "issn-l": null}, "abstract": "The first case of COVID-19 was reported in Iran on February 19, 2020, in Qom. Since Mazandaran is one of the high-risk provinces with many patients and deaths, this study was conducted to investigate the epidemiological characteristics of COVID-19-related deaths in Mazandaran.\n\nIn this descriptive study, demographic information and clinical findings in patients who died following COVID-19 in the medical centers of Mazandaran University of Medical Sciences from February 8, 2020, to October 10, 2020, were extracted. Data were analyzed by using SPSS 21. Logistic regression was used to compare the data. P < 0.05 was considered as the significance level.\n\nOut of a total of 34,039 patients admitted during the 8 months, 2907 patients died. Of these, 1529 (52%) were male, and the rest were female. In terms of age, 10 cases in the age group of fewer than 15 years, 229 cases in the age group of 15-44 years, 864 patients in the age group of 45-64 years, and 1793 people in the age group of 65 years and over died. 2206 people (more than 75%) by personal visit referred to medical centers. The mortality rate was more than 8 cases per 100 hospitalized patients. Men were 16% more likely to die from COVID-19 than women.\n\nOlder adults over 65 have the highest incidence and death rate due to this disease. The incidence rate was higher in women, and the death rate was higher in men, which differs from the national pattern.", "doi": "10.4103/jehp.jehp_192_21", "pmid": "35071632", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "JEHP-10-426"}, {"db": "pmc", "key": "PMC8719545"}], "notes": [], "created": "2022-01-26T10:16:48.419Z", "modified": "2022-01-26T10:16:48.452Z"}, {"entity": "publication", "iuid": "d4d0b48d3aee47a6b6f277156b63cfc3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4d0b48d3aee47a6b6f277156b63cfc3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4d0b48d3aee47a6b6f277156b63cfc3"}}, "title": "Effects of immunosuppressive drugs on COVID-19 severity in patients with autoimmune hepatitis.", "authors": [{"family": "Efe", "given": "Cumali", "initials": "C", "orcid": "0000-0001-6593-5702", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cd621ab96e04e678b0188c48d54b90a.json"}}, {"family": "Lammert", "given": "Craig", "initials": "C", "orcid": "0000-0003-3809-640X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3c2fe9871074a22a95a55375edc3b62.json"}}, {"family": "Ta\u015f\u00e7\u0131lar", "given": "Koray", "initials": "K"}, {"family": "Dhanasekaran", "given": "Renumathy", "initials": "R", "orcid": "0000-0001-8819-7511", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/144c4ddb38ed4c99adca4b6ae626a533.json"}}, {"family": "Ebik", "given": "Berat", "initials": "B"}, {"family": "Higuera-de la Tijera", "given": "Fatima", "initials": "F"}, {"family": "Cal\u0131\u015fkan", "given": "Ali R", "initials": "AR"}, {"family": "Peralta", "given": "Mirta", "initials": "M"}, {"family": "Gerussi", "given": "Alessio", "initials": "A"}, {"family": "Massoumi", "given": "Hatef", "initials": "H"}, {"family": "Catana", "given": "Andreea M", "initials": "AM"}, {"family": "Purnak", "given": "Tugrul", "initials": "T"}, {"family": "Rigamonti", "given": "Cristina", "initials": "C"}, {"family": "Aldana", "given": "Andres J G", "initials": "AJG"}, {"family": "Khakoo", "given": "Nidah", "initials": "N"}, {"family": "Nazal", "given": "Leyla", "initials": "L"}, {"family": "Frager", "given": "Shalom", "initials": "S"}, {"family": "Demir", "given": "Nurhan", "initials": "N"}, {"family": "Irak", "given": "Kader", "initials": "K"}, {"family": "Meleko\u011flu-Ellik", "given": "Zeynep", "initials": "Z"}, {"family": "Kacmaz", "given": "H\u00fcseyin", "initials": "H"}, {"family": "Balaban", "given": "Yasemin", "initials": "Y"}, {"family": "Atay", "given": "Kadri", "initials": "K"}, {"family": "Eren", "given": "Fatih", "initials": "F"}, {"family": "Alvares-da-Silva", "given": "Mario R", "initials": "MR"}, {"family": "Cristoferi", "given": "Laura", "initials": "L"}, {"family": "Urzua", "given": "\u00c1lvaro", "initials": "\u00c1"}, {"family": "E\u015fkazan", "given": "Tu\u011f\u00e7e", "initials": "T"}, {"family": "Magro", "given": "Bianca", "initials": "B"}, {"family": "Snijders", "given": "Romee", "initials": "R"}, {"family": "Barut\u00e7u", "given": "Sezgin", "initials": "S"}, {"family": "Lytvyak", "given": "Ellina", "initials": "E"}, {"family": "Zazueta", "given": "Godolfino M", "initials": "GM"}, {"family": "Demirezer-Bolat", "given": "Aylin", "initials": "A"}, {"family": "Ayd\u0131n", "given": "Mesut", "initials": "M"}, {"family": "Heurgue-Berlot", "given": "Alexandra", "initials": "A"}, {"family": "De Martin", "given": "Eleonora", "initials": "E"}, {"family": "Ekin", "given": "Naz\u0131m", "initials": "N"}, {"family": "Y\u0131ld\u0131r\u0131m", "given": "S\u00fcmeyra", "initials": "S"}, {"family": "Yavuz", "given": "Ahmet", "initials": "A"}, {"family": "B\u0131y\u0131k", "given": "Murat", "initials": "M"}, {"family": "Narro", "given": "Graciela C", "initials": "GC"}, {"family": "K\u0131y\u0131c\u0131", "given": "Murat", "initials": "M"}, {"family": "Aky\u0131ld\u0131z", "given": "Murat", "initials": "M"}, {"family": "Kahramano\u011flu-Aksoy", "given": "Evrim", "initials": "E"}, {"family": "Vincent", "given": "Maria", "initials": "M"}, {"family": "Carr", "given": "Rotonya M", "initials": "RM"}, {"family": "G\u00fcn\u015far", "given": "Fulya", "initials": "F"}, {"family": "Reyes", "given": "Eira C", "initials": "EC"}, {"family": "Harputluo\u011flu", "given": "Murat", "initials": "M"}, {"family": "Aloman", "given": "Costica", "initials": "C"}, {"family": "Gatselis", "given": "Nikolaos K", "initials": "NK"}, {"family": "\u00dcst\u00fcnda\u011f", "given": "Y\u00fccel", "initials": "Y"}, {"family": "Brahm", "given": "Javier", "initials": "J"}, {"family": "Vargas", "given": "Nataly C E", "initials": "NCE"}, {"family": "G\u00fczelbulut", "given": "Fatih", "initials": "F", "orcid": "0000-0003-4889-208X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b376f922688245a6a37c9d9db086c5c0.json"}}, {"family": "Garcia", "given": "Sandro R", "initials": "SR"}, {"family": "Aguirre", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-6291-2545", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e597179292724adeafa651fb99c26573.json"}}, {"family": "Anders", "given": "Margarita", "initials": "M"}, {"family": "Ratusnu", "given": "Natalia", "initials": "N"}, {"family": "Hatemi", "given": "Ibrahim", "initials": "I"}, {"family": "Mendizabal", "given": "Manuel", "initials": "M"}, {"family": "Floreani", "given": "Annarosa", "initials": "A"}, {"family": "Fagiuoli", "given": "Stefano", "initials": "S"}, {"family": "Silva", "given": "Marcelo", "initials": "M"}, {"family": "Idilman", "given": "Ramazan", "initials": "R"}, {"family": "Satapathy", "given": "Sanjaya K", "initials": "SK", "orcid": "0000-0003-0153-2829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46079042944846e2a2ab5791ffd3ac85.json"}}, {"family": "Silveira", "given": "Marina", "initials": "M"}, {"family": "Drenth", "given": "Joost P H", "initials": "JPH", "orcid": "0000-0001-8027-3073", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7b6dc5554ee4911b90e100f311d69ca.json"}}, {"family": "Dalekos", "given": "George N", "initials": "GN"}, {"family": "N Assis", "given": "David", "initials": "D"}, {"family": "Bj\u00f6rnsson", "given": "Einar", "initials": "E", "orcid": "0000-0002-8392-0632", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d61afcd69274877ab6be778e0b191f6.json"}}, {"family": "Boyer", "given": "James L", "initials": "JL"}, {"family": "Yoshida", "given": "Eric M", "initials": "EM"}, {"family": "Invernizzi", "given": "Pietro", "initials": "P", "orcid": "0000-0003-3262-1998", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2e4ae30eec648eea09a264143952d7e.json"}}, {"family": "Levy", "given": "Cynthia", "initials": "C", "orcid": "0000-0001-5498-6037", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15588be194364b57b71d2f15526456c7.json"}}, {"family": "Montano-Loza", "given": "Aldo J", "initials": "AJ", "orcid": "0000-0002-2511-7980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a64b4bf7fe0848c6bde4f61b031d8900.json"}}, {"family": "Schiano", "given": "Thomas D", "initials": "TD"}, {"family": "Ridruejo", "given": "Ezequiel", "initials": "E"}, {"family": "Wahlin", "given": "Staffan", "initials": "S"}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "Liver Int", "issn": "1478-3231", "issn-l": null}, "abstract": "We investigated associations between baseline use of immunosuppressive drugs and severity of Coronavirus Disease 2019 (COVID-19) in autoimmune hepatitis (AIH).\n\nData of AIH patients with laboratory confirmed COVID-19 were retrospectively collected from 15 countries. The outcomes of AIH patients who were on immunosuppression at the time of COVID-19 were compared to patients who were not on AIH medication. The clinical courses of COVID-19 were classified as (i)-no hospitalization, (ii)-hospitalization without oxygen supplementation, (iii)-hospitalization with oxygen supplementation by nasal cannula or mask, (iv)-intensive care unit (ICU) admission with non-invasive mechanical ventilation, (v)-ICU admission with invasive mechanical ventilation or (vi)-death and analysed using ordinal logistic regression.\n\nWe included 254 AIH patients (79.5%, female) with a median age of 50 (range, 17-85) years. At the onset of COVID-19, 234 patients (92.1%) were on treatment with glucocorticoids (n = 156), thiopurines (n = 151), mycophenolate mofetil (n = 22) or tacrolimus (n = 16), alone or in combinations. Overall, 94 (37%) patients were hospitalized and 18 (7.1%) patients died. Use of systemic glucocorticoids (adjusted odds ratio [aOR] 4.73, 95% CI 1.12-25.89) and thiopurines (aOR 4.78, 95% CI 1.33-23.50) for AIH was associated with worse COVID-19 severity, after adjusting for age-sex, comorbidities and presence of cirrhosis. Baseline treatment with mycophenolate mofetil (aOR 3.56, 95% CI 0.76-20.56) and tacrolimus (aOR 4.09, 95% CI 0.69-27.00) were also associated with more severe COVID-19 courses in a smaller subset of treated patients.\n\nBaseline treatment with systemic glucocorticoids or thiopurines prior to the onset of COVID-19 was significantly associated with COVID-19 severity in patients with AIH.", "doi": "10.1111/liv.15121", "pmid": "34846800", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T18:10:28.983Z", "modified": "2021-12-18T18:10:29.323Z"}, {"entity": "publication", "iuid": "1ff9c3f0e55f4ec5bac4e50071aa7305", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ff9c3f0e55f4ec5bac4e50071aa7305.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ff9c3f0e55f4ec5bac4e50071aa7305"}}, "title": "Cohort study of the characteristics and outcomes in patients with COVID-19 and in-hospital cardiac arrest.", "authors": [{"family": "Holm", "given": "Astrid", "initials": "A", "orcid": "0000-0003-4226-7494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7dede94c48304ae09e2db9691584ab36.json"}}, {"family": "Jerkeman", "given": "Matilda", "initials": "M"}, {"family": "Sultanian", "given": "Pedram", "initials": "P", "orcid": "0000-0002-6941-6659", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/903a11645aaa4218bd36f1e51187783c.json"}}, {"family": "Lundgren", "given": "Peter", "initials": "P"}, {"family": "Ravn-Fischer", "given": "Annica", "initials": "A"}, {"family": "Israelsson", "given": "Johan", "initials": "J"}, {"family": "Giesecke", "given": "Jasna", "initials": "J"}, {"family": "Herlitz", "given": "Johan", "initials": "J"}, {"family": "Rawshani", "given": "Araz", "initials": "A", "orcid": "0000-0003-2066-3533", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ffcc83bb40a4a22aec7dffe6c890da0.json"}}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "11", "pages": "e054943", "issn-l": "2044-6055"}, "abstract": "We studied characteristics, survival, causes of cardiac arrest, conditions preceding cardiac arrest, predictors of survival and trends in the prevalence of COVID-19 among in-hospital cardiac arrest (IHCA) cases.\n\nRegistry-based observational study.\n\nWe studied all cases (\u226518 years of age) of IHCA receiving cardiopulmonary resuscitation in the Swedish Registry for Cardiopulmonary Resuscitation during 15 March 2020 to 31 December 2020. A total of 1613 patients were included and divided into the following groups: ongoing infection (COVID-19+; n=182), no infection (COVID-19-; n=1062) and unknown/not assessed (n=369).\n\nWe studied monthly trends in proportions of COVID-19 associated IHCAs, causes of IHCA in relation to COVID-19 status, clinical conditions preceding the cardiac arrest and predictors of survival.\n\nThe rate of COVID-19+ patients suffering an IHCA increased to 23% during the first pandemic wave (April), then abated to 3% in July, and then increased to 19% during the second wave (December). Among COVID-19+ cases, 43% had respiratory insufficiency or infection as the underlying cause of the cardiac arrest, compared with 18% among COVID-19- cases. The most common clinical sign preceding cardiac arrest was hypoxia (57%) among COVID-19+ cases. OR for 30-day survival for COVID-19+ cases was 0.50 (95% CI 0.33 to 0.76), compared with COVID-19- cases.\n\nDuring pandemic peaks, up to one-fourth of all IHCAs are complicated by COVID-19, and these patients have halved chance of survival, with women displaying the worst outcomes.", "doi": "10.1136/bmjopen-2021-054943", "pmid": "34848525", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-054943"}, {"db": "pmc", "key": "PMC8635887"}], "notes": [], "created": "2021-12-18T18:09:55.672Z", "modified": "2021-12-18T18:09:55.806Z"}, {"entity": "publication", "iuid": "3e5fbd3eafad422c9ff64235ae8e42eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3e5fbd3eafad422c9ff64235ae8e42eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3e5fbd3eafad422c9ff64235ae8e42eb"}}, "title": "Avoiding bias in self-controlled case series studies of coronavirus disease 2019.", "authors": [{"family": "Fonseca-Rodr\u00edguez", "given": "Osvaldo", "initials": "O"}, {"family": "Fors Connolly", "given": "Anne-Marie", "initials": "AM", "orcid": "0000-0001-9215-4047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff46cc7d9e374929a14350748727ba60.json"}}, {"family": "Katsoularis", "given": "Ioannis", "initials": "I"}, {"family": "Lindmark", "given": "Krister", "initials": "K"}, {"family": "Farrington", "given": "Paddy", "initials": "P", "orcid": "0000-0002-7148-2612", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/586b1e765406444d85c192ba61708ce0.json"}}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "Stat Med", "issn": "1097-0258", "issn-l": null, "volume": "40", "issue": "27", "pages": "6197-6208"}, "abstract": "Many studies, including self-controlled case series (SCCS) studies, are being undertaken to quantify the risks of complications following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). One such SCCS study, based on all COVID-19 cases arising in Sweden over an 8-month period, has shown that SARS-CoV-2 infection increases the risks of AMI and ischemic stroke. Some features of SARS-CoV-2 infection and COVID-19, present in this study and likely in others, complicate the analysis and may introduce bias. In the present paper we describe these features, and explore the biases they may generate. Motivated by data-based simulations, we propose methods to reduce or remove these biases.", "doi": "10.1002/sim.9179", "pmid": "34470078", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8661887"}], "notes": [], "created": "2021-09-06T06:17:45.140Z", "modified": "2023-06-19T14:47:13.405Z"}, {"entity": "publication", "iuid": "bd9c86c4cf594ec6a0e7a3155401ba54", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bd9c86c4cf594ec6a0e7a3155401ba54.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bd9c86c4cf594ec6a0e7a3155401ba54"}}, "title": "Application of Stem Cell-Derived Extracellular Vesicles as an Innovative Theranostics in Microbial Diseases.", "authors": [{"family": "Keshavarz Alikhani", "given": "Hani", "initials": "H"}, {"family": "Shokoohian", "given": "Bahare", "initials": "B"}, {"family": "Rezasoltani", "given": "Sama", "initials": "S"}, {"family": "Hossein-Khannazer", "given": "Nikoo", "initials": "N"}, {"family": "Yadegar", "given": "Abbas", "initials": "A"}, {"family": "Hassan", "given": "Moustapha", "initials": "M"}, {"family": "Vosough", "given": "Massoud", "initials": "M"}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "Front Microbiol", "issn": "1664-302X", "volume": "12", "pages": "785856", "issn-l": null}, "abstract": "Extracellular vesicles (EVs), as nano-/micro-scale vehicles, are membranous particles containing various cargoes including peptides, proteins, different types of RNAs and other nucleic acids, and lipids. These vesicles are produced by all cell types, in which stem cells are a potent source for them. Stem cell-derived EVs could be promising platforms for treatment of infectious diseases and early diagnosis. Infectious diseases are responsible for more than 11 million deaths annually. Highly transmissible nature of some microbes, such as newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), drives researcher's interest to set up different strategies to develop novel therapeutic strategies. Recently, EVs-based diagnostic and therapeutic approaches have been launched and gaining momentum very fast. The efficiency of stem cell-derived EVs on treatment of clinical complications of different viruses and bacteria, such as SARS-CoV-2, hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), Staphylococcus aureus, Escherichia coli has been demonstrated. On the other hand, microbial pathogens are able to incorporate their components into their EVs. The microbe-derived EVs have different physiological and pathological impacts on the other organisms. In this review, we briefly discussed biogenesis and the fate of EVs. Then, EV-based therapy was described and recent developments in understanding the potential application of stem cell-derived EVs on pathogenic microorganisms were recapitulated. Furthermore, the mechanisms by which EVs were exploited to fight against infectious diseases were highlighted. Finally, the deriver challenges in translation of stem cell-derived EVs into the clinical arena were explored.", "doi": "10.3389/fmicb.2021.785856", "pmid": "34917064", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8669997"}], "notes": [], "created": "2021-12-18T17:41:45.760Z", "modified": "2021-12-18T17:42:00.602Z"}, {"entity": "publication", "iuid": "61cb9195191e453f9f426b4888551047", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61cb9195191e453f9f426b4888551047.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61cb9195191e453f9f426b4888551047"}}, "title": "Using Ecological Momentary Assessment to Study the Development of COVID-19 Worries in Sweden: Longitudinal Study.", "authors": [{"family": "Schulz", "given": "Peter Johannes", "initials": "PJ", "orcid": "0000-0003-4281-489X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e186ea7760d84db695253b781d054226.json"}}, {"family": "Andersson", "given": "Elin M", "initials": "EM", "orcid": "0000-0002-9847-4196", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/febdb7c142b048deb0b5ffd9f998f289.json"}}, {"family": "Bizzotto", "given": "Nicole", "initials": "N", "orcid": "0000-0002-4730-1367", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ccad820d0f746ef92ca47b5e24a17fb.json"}}, {"family": "Norberg", "given": "Margareta", "initials": "M", "orcid": "0000-0003-2475-7131", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d9734ccbd5e46c5be2b3922d9af4b81.json"}}], "type": "journal article", "published": "2021-11-29", "journal": {"title": "J Med Internet Res", "issn": "1438-8871", "volume": "23", "issue": "11", "pages": "e26743", "issn-l": null}, "abstract": "The foray of COVID-19 around the globe has certainly instigated worries in many people, and lockdown measures may well have triggered more specific worries. Sweden, more than other countries, relied on voluntary measures to fight the pandemic. This provides a particularly interesting context to assess people's reactions to the threat of the pandemic.\n\nThe general aim of this study was to better understand the worried reactions to the virus and the associated lockdown measures. As there have been very few longitudinal studies in this area published to date, development of feelings of worry over time was analyzed over a longer range than in previous research. Affective variables, worry in particular, were included because most of the research in this field has focused on cognitive variables. To employ new methodology, ecological momentary assessment was used for data collection and a multilevel modeling approach was adopted for data analysis.\n\nResults were based on an unbalanced panel sample of 260 Swedish participants filling in 3226 interview questionnaires by smartphone over a 7-week period in 2020 during the rapid rise of cases in the early phase of the pandemic. Causal factors considered in this study included the perceived severity of an infection, susceptibility of a person to the threat posed by the virus, perceived efficacy of safeguarding measures, and assessment of government action against the spread of COVID-19. The effect of these factors on worries was traced in two analytical steps: the effects at the beginning of the study and the effect on the trend during the study.\n\nThe level of general worry related to COVID-19 was modest (mean 6.67, SD 2.54 on an 11-point Likert scale); the increase during the study period was small, but the interindividual variation of both the worry level and its increase over time was large. Findings confirmed that the hypothesized causal factors (severity of infection, susceptibility to the threat of the virus, efficacy of safeguarding, and assessment of government preventive action) did indeed affect the level of worry.\n\nThe results confirmed earlier research in a very special case and demonstrated the usefulness of a different study design, which takes a longitudinal perspective, and a new type of data analysis borrowed from multilevel study design.", "doi": "10.2196/26743", "pmid": "34847065", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "v23i11e26743"}], "notes": [], "created": "2021-12-18T18:10:14.526Z", "modified": "2021-12-18T18:10:14.690Z"}, {"entity": "publication", "iuid": "383c0fe192104c33b63bb8e5ec51a54a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/383c0fe192104c33b63bb8e5ec51a54a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/383c0fe192104c33b63bb8e5ec51a54a"}}, "title": "The Glomerular Endothelium Restricts Albumin Filtration.", "authors": [{"family": "Ballermann", "given": "Barbara J", "initials": "BJ"}, {"family": "Nystr\u00f6m", "given": "Jenny", "initials": "J"}, {"family": "Haraldsson", "given": "B\u00f6rje", "initials": "B"}], "type": "journal article", "published": "2021-11-29", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "8", "pages": "766689", "issn-l": null}, "abstract": "Inflammatory activation and/or dysfunction of the glomerular endothelium triggers proteinuria in many systemic and localized vascular disorders. Among them are the thrombotic microangiopathies, many forms of glomerulonephritis, and acute inflammatory episodes like sepsis and COVID-19 illness. Another example is the chronic endothelial dysfunction that develops in cardiovascular disease and in metabolic disorders like diabetes. While the glomerular endothelium is a porous sieve that filters prodigious amounts of water and small solutes, it also bars the bulk of albumin and large plasma proteins from passing into the glomerular filtrate. This endothelial barrier function is ascribed predominantly to the endothelial glycocalyx with its endothelial surface layer, that together form a relatively thick, mucinous coat composed of glycosaminoglycans, proteoglycans, glycolipids, sialomucins and other glycoproteins, as well as secreted and circulating proteins. The glycocalyx/endothelial surface layer not only covers the glomerular endothelium; it extends into the endothelial fenestrae. Some glycocalyx components span or are attached to the apical endothelial cell plasma membrane and form the formal glycocalyx. Other components, including small proteoglycans and circulating proteins like albumin and orosomucoid, form the endothelial surface layer and are bound to the glycocalyx due to weak intermolecular interactions. Indeed, bound plasma albumin is a major constituent of the endothelial surface layer and contributes to its barrier function. A role for glomerular endothelial cells in the barrier of the glomerular capillary wall to protein filtration has been demonstrated by many elegant studies. However, it can only be fully understood in the context of other components, including the glomerular basement membrane, the podocytes and reabsorption of proteins by tubule epithelial cells. Discovery of the precise mechanisms that lead to glycocalyx/endothelial surface layer disruption within glomerular capillaries will hopefully lead to pharmacological interventions that specifically target this important structure.", "doi": "10.3389/fmed.2021.766689", "pmid": "34912827", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8667033"}], "notes": [], "created": "2021-12-18T17:48:23.056Z", "modified": "2022-01-04T15:36:39.995Z"}, {"entity": "publication", "iuid": "c3ab6905010440e1a70238b3d4ff0777", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3ab6905010440e1a70238b3d4ff0777.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3ab6905010440e1a70238b3d4ff0777"}}, "title": "Safety and efficacy of the mRNA BNT162b2 vaccine against SARS-CoV-2 in five groups of immunocompromised patients and healthy controls in a prospective open-label clinical trial.", "authors": [{"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Mielke", "given": "Stephan", "initials": "S"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "S\u00f6derdahl", "given": "Gunnar", "initials": "G"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Vesterbacka", "given": "Jan", "initials": "J"}, {"family": "Lindgren", "given": "Gustaf", "initials": "G"}, {"family": "Blixt", "given": "Lisa", "initials": "L"}, {"family": "Friman", "given": "Gustav", "initials": "G"}, {"family": "Wahren-Borgstr\u00f6m", "given": "Emilie", "initials": "E"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Gomez", "given": "Angelica Cuapio", "initials": "AC"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Valentini", "given": "Davide", "initials": "D"}, {"family": "Norlin", "given": "Anna-Carin", "initials": "A"}, {"family": "Thalme", "given": "Anders", "initials": "A"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "Chen", "given": "Margaret S\u00e4llberg", "initials": "MS"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "COVAXID-collaborator group (shown separately)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-29", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": "74", "issue": null, "pages": "103705"}, "abstract": "Patients with immunocompromised disorders have mainly been excluded from clinical trials of vaccination against COVID-19. Thus, the aim of this prospective clinical trial was to investigate safety and efficacy of BNT162b2 mRNA vaccination in five selected groups of immunocompromised patients and healthy controls.\r\n\r\n539 study subjects (449 patients and 90 controls) were included. The patients had either primary (n=90), or secondary immunodeficiency disorders due to human immunodeficiency virus infection (n=90), allogeneic hematopoietic stem cell transplantation/CAR T cell therapy (n=90), solid organ transplantation (SOT) (n=89), or chronic lymphocytic leukemia (CLL) (n=90). The primary endpoint was seroconversion rate two weeks after the second dose. The secondary endpoints were safety and documented SARS-CoV-2 infection.\r\n\r\nAdverse events were generally mild, but one case of fatal suspected unexpected serious adverse reaction occurred. 72.2% of the immunocompromised patients seroconverted compared to 100% of the controls (p=0.004). Lowest seroconversion rates were found in the SOT (43.4%) and CLL (63.3%) patient groups with observed negative impact of treatment with mycophenolate mofetil and ibrutinib, respectively.\r\n\r\nThe results showed that the mRNA BNT162b2 vaccine was safe in immunocompromised patients. Rate of seroconversion was substantially lower than in healthy controls, with a wide range of rates and antibody titres among predefined patient groups and subgroups. This clinical trial highlights the need for additional vaccine doses in certain immunocompromised patient groups to improve immunity.\r\n\r\nKnut and Alice Wallenberg Foundation, the Swedish Research Council, Nordstjernan AB, Region Stockholm, Karolinska Institutet, and organizations for PID/CLL-patients in Sweden.", "doi": "10.1016/j.ebiom.2021.103705", "pmid": "34861491", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Research Area: Vaccine": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S2352-3964(21)00499-0"}, {"db": "pmc", "key": "PMC8629680"}], "notes": [], "created": "2021-12-13T06:18:22.479Z", "modified": "2022-02-08T19:23:35.378Z"}, {"entity": "publication", "iuid": "9772ddb501a945128727b5f4d0cad4da", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9772ddb501a945128727b5f4d0cad4da.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9772ddb501a945128727b5f4d0cad4da"}}, "title": "Evaluation of an Access-Risk-Knowledge (ARK) Platform for Governance of Risk and Change in Complex Socio-Technical Systems", "authors": [{"family": "McDonald", "given": "Nick", "initials": "N"}, {"family": "McKenna", "given": "Lucy", "initials": "L", "orcid": "0000-0002-6035-7656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b86ff32ca1bf48159697fb2fe2f9551b.json"}}, {"family": "Vining", "given": "Rebecca", "initials": "R", "orcid": "0000-0002-2715-8129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6439c14ee8414e53af9294862d552196.json"}}, {"family": "Doyle", "given": "Brian", "initials": "B", "orcid": "0000-0002-9106-9526", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5dadad0ba26f4f6080691dee6f5a74dd.json"}}, {"family": "Liang", "given": "Junli", "initials": "J"}, {"family": "Ward", "given": "Marie E", "initials": "ME", "orcid": "0000-0002-6638-8461", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c905fcea73cc450cbe0e74287b0eb109.json"}}, {"family": "Ulfvengren", "given": "Pernilla", "initials": "P", "orcid": "0000-0002-9709-540X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc00902f545941139d3a4cce8187eae1.json"}}, {"family": "Geary", "given": "Una", "initials": "U"}, {"family": "Guilfoyle", "given": "John", "initials": "J"}, {"family": "Shuhaiber", "given": "Arwa", "initials": "A"}, {"family": "Hernandez", "given": "Julio", "initials": "J", "orcid": "0000-0003-1347-9631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0184091779e41ecbc5d33105d23034c.json"}}, {"family": "Fogarty", "given": "Mary", "initials": "M"}, {"family": "Healy", "given": "Una", "initials": "U"}, {"family": "Tallon", "given": "Christopher", "initials": "C"}, {"family": "Brennan", "given": "Rob", "initials": "R", "orcid": "0000-0001-8236-362X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94edffbb874e4802bba1ef5efb442c4b.json"}}], "type": "journal-article", "published": "2021-11-29", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "23", "pages": "12572", "issn-l": null}, "abstract": null, "doi": "10.3390/ijerph182312572", "pmid": null, "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:56:14.716Z", "modified": "2021-12-12T06:56:14.981Z"}, {"entity": "publication", "iuid": "e7a3924e7b744217b6a3a136c7aadeec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e7a3924e7b744217b6a3a136c7aadeec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e7a3924e7b744217b6a3a136c7aadeec"}}, "title": "Coronavirus disease 2019 in patients with Behcet's disease: a report of 59 cases in Iran.", "authors": [{"family": "Shahram", "given": "Farhad", "initials": "F", "orcid": "0000-0003-1830-6203", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54cc2725d5914d2eb2b8de5bce99c147.json"}}, {"family": "Esalatmanesh", "given": "Kamal", "initials": "K", "orcid": "0000-0001-9675-5237", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b00277eb98524eadbd9d4524e3958a38.json"}}, {"family": "Khabbazi", "given": "Alireza", "initials": "A", "orcid": "0000-0002-9482-6967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c640608a4c7450e9684bcb7b81b6d90.json"}}, {"family": "Rezaieyazdi", "given": "Zahra", "initials": "Z", "orcid": "0000-0001-8731-7999", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cedb94d93a434d37825e67d516b9cd33.json"}}, {"family": "Mirfeizi", "given": "Zahra", "initials": "Z"}, {"family": "Sadeghi", "given": "Alireza", "initials": "A", "orcid": "0000-0002-7406-4790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5682d53ed18245b6a00334b4aaa8c710.json"}}, {"family": "Soroosh", "given": "Mohsen", "initials": "M"}, {"family": "Kavosi", "given": "Hoda", "initials": "H", "orcid": "0000-0003-4762-6943", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b435e9ba4d1c4a999585594ab71664f9.json"}}, {"family": "Alikhani", "given": "Majid", "initials": "M"}, {"family": "Mostafaei", "given": "Shayan", "initials": "S", "orcid": "0000-0002-1966-1306", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24bfddb5f547448e88fa79f34c78ee23.json"}}], "type": "journal article", "published": "2021-11-29", "journal": {"title": "Clin Rheumatol", "issn": "1434-9949", "issn-l": null}, "abstract": "To present the clinical characteristics, disease course, management, and outcomes of COVID-19 infection in patients with Behcet's disease (BD).\n\nIn this retrospective cohort study, we retrieved BD patients with definite diagnosis of COVID-19 infection. Demographic data, comorbidities, features related both to BD and COVID-19 infection, treatments, and outcomes were collected. Comparisons between patients with or without hospitalization were performed. All statistical analyzes were performed using SPSS version 25. We considered p < 0.05 statistically significant.\n\nWe identified 61 episodes of COVID-19 infection in 59 BD patients. The prevalence was 0.69%. The median age was 45 years (IQR = 20), and the median disease duration was 162 months (IQR = 195). BD features were similar except for higher rate of arterial involvement and positive pathergy test in infected patients. Thirty-five episodes (62.5%) happened in non-active patients; 39% had a comorbid disease. COVID manifestations were the same as the general population. Flu-like symptoms were the most common (85%), followed by fever (66%), ageusia/anosmia (56%), headache (51%), and pulmonary involvement (48%). There was no change in BD symptoms in 74%. Fifteen patients (25.4%) were hospitalized, and one patient (1.7%) died. Receiving glucocorticoids (p < 0.03) and cytotoxic drugs (p < 0.02) were associated with an increased rate of hospitalization.\n\nThe incidence of COVID-19 infection in BD patients was not higher than general population in Iran. They showed milder form of disease with lower morbidity and mortality rate. Most were on immunosuppressive drugs, or had a comorbidity apart from BD. No significant effect on BD course was shown. Key Points \u2022 The incidence of COVID-19 infection in patients with Behcet's disease is not higher. \u2022 They showed milder form of infection with lower morbidity and mortality rate. \u2022 No significant effect on Behcet's disease course was shown with COVID19 infection. \u2022 BD patients can be managed according to the guidelines used for general population.", "doi": "10.1007/s10067-021-06004-y", "pmid": "34842999", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10067-021-06004-y"}, {"db": "pmc", "key": "PMC8628030"}], "notes": [], "created": "2021-12-18T18:12:18.769Z", "modified": "2021-12-18T18:12:29.094Z"}, {"entity": "publication", "iuid": "22607e4c502043ae9c2d0bb4e98a8a8f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/22607e4c502043ae9c2d0bb4e98a8a8f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/22607e4c502043ae9c2d0bb4e98a8a8f"}}, "title": "COVID-19 Fear Among Pakistanis: Psychometric Evaluation of the Fear of COVID-19 Scale Using Item Response Theory and Confirmatory Factor Analysis.", "authors": [{"family": "Ullah", "given": "Irfan", "initials": "I", "orcid": "0000-0003-1100-101X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8d5a7e15ae6487cbdda0de3b2a531c3.json"}}, {"family": "Tahir", "given": "Muhammad Junaid", "initials": "MJ", "orcid": "0000-0002-0335-6681", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3192523e30b47e4ba6579ed8ab36661.json"}}, {"family": "Ali", "given": "Sajjad", "initials": "S", "orcid": "0000-0002-8024-5942", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26d9173903254605b87536aacb209621.json"}}, {"family": "Waseem", "given": "Rabia", "initials": "R"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA", "orcid": "0000-0002-1728-8966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6e65a5a97154d159a63cc2ce3f1b7a8.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-11-29", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "pages": "1-16", "issn-l": null}, "abstract": "The Fear of COVID-19 Scale (FCV-19S) assesses the fear of the novel coronavirus disease 2019 (COVID-19) and has been translated and validated into over 20 languages. The present study conducted confirmatory factor analysis (CFA) and item response theory (IRT) analyses on the FCV-19S among a sample of 937 Pakistani adults (mean [SD] age of 25.83 [11.80] years; 537 [57.3%] females). The CFA and IRT confirmed the unidimensionality of the FCV-19S. The Likert-type scale used in the FCV-19S was supported by the proper threshold orderings. Additionally, no DIF contrast had an absolute value larger than 0.5 regarding the participants' characteristics of gender, age, living status, and education in the IRT findings. The FCV-19S was found to be valid and reliable with strong psychometric properties among the Pakistani adult population.", "doi": "10.1007/s11469-021-00656-2", "pmid": "34867122", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "656"}, {"db": "pmc", "key": "PMC8628831"}], "notes": [], "created": "2021-12-13T06:07:01.885Z", "modified": "2021-12-13T06:07:20.741Z"}, {"entity": "publication", "iuid": "61ae5f5a56ba41f4909e80b7caa89fce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61ae5f5a56ba41f4909e80b7caa89fce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61ae5f5a56ba41f4909e80b7caa89fce"}}, "title": "A Survey of Psychiatric Healthcare Workers' Perception of Working Environment and Possibility to Recover Before and After the First Wave of COVID-19 in Sweden.", "authors": [{"family": "Alexiou", "given": "Eirini", "initials": "E"}, {"family": "Steingrimsson", "given": "Steinn", "initials": "S"}, {"family": "Akerstrom", "given": "Magnus", "initials": "M"}, {"family": "Jonsdottir", "given": "Ingibj\u00f6rg H", "initials": "IH"}, {"family": "Ahlstrom", "given": "Linda", "initials": "L"}, {"family": "Finizia", "given": "Caterina", "initials": "C"}, {"family": "Wijk", "given": "Helle", "initials": "H"}, {"family": "Degl'Innocenti", "given": "Alessio", "initials": "A"}], "type": "journal article", "published": "2021-11-29", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "770955", "issn-l": "1664-0640"}, "abstract": "Objective: This study aimed to investigate the impact of the first wave of the COVID-19 pandemic on perceived working environment, including the possibility to recover, among psychiatric healthcare workers (PHCWs) in comparison with pre-pandemic measures. Method: A link to an anonymous, web-based COVID-19 related survey was sent via email to all PHCWs at a university hospital in Sweden (n = 1,618) in September 2020. The response rate was 38% (566 of 1,507 eligible participants). Working environment survey responses collected in 2019 were used as pre-pandemic comparators. Statistical analyses were performed to assess overall impact over time on work demands, support, motivation, and recovery, stratified by professional role, and considering variables such as access to personal protective equipment. Results: The percentage of individuals responding negatively to statements about working environment increased significantly for most items after the first wave. Similarly, the increase of five of the investigated factors indicated a more negative perception of recovery during the pandemic. Registered nurses reported a greater negative impact of the pandemic on perceived working conditions and ability to recover than other professional groups. PHCWs working with patients with COVID-19 (35%) who reported being worried about becoming infected (12%) or infecting others (17%), or lacking adequate personal protective equipment (22%) were more negatively impacted regarding work environment-related items than those who did not. Conclusions: PHCWs' working environment and possibility for recovery were impacted by the first wave of the COVID-19 pandemic, nurses being most affected. Although psychiatric services do not directly care for patients with severe COVID-19 infection, the results from this study suggests that mental health services should also prepare for future pandemics.", "doi": "10.3389/fpsyt.2021.770955", "pmid": "34912253", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8666504"}], "notes": [], "created": "2021-12-18T17:48:55.226Z", "modified": "2022-01-04T15:36:57.557Z"}, {"entity": "publication", "iuid": "70c06bfda3fd453ea00196690a20d869", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70c06bfda3fd453ea00196690a20d869.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70c06bfda3fd453ea00196690a20d869"}}, "title": "The Meaning of Critical Illness for People Suffering From COVID-19: When a Frightening Unreality Becomes Reality.", "authors": [{"family": "Engstr\u00f6m", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0001-6244-6401", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f93844031da44a79bc89f3d73da4477f.json"}}, {"family": "Juuso", "given": "P\u00e4ivi", "initials": "P"}, {"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Nordin", "given": "Anna", "initials": "A"}, {"family": "Str\u00f6mb\u00e4ck", "given": "Ulrica", "initials": "U"}], "type": "journal article", "published": "2021-11-27", "journal": {"title": "Qual Health Res", "issn": "1049-7323", "pages": "10497323211050048", "issn-l": null}, "abstract": "The aim of this study was to elucidate the meaning of critical illness for people with COVID-19. This study used a qualitative design. Thirteen people who were critically ill with COVID-19 during 2020 and admitted to a COVID-19 intensive care unit in northern Sweden participated in the study. Data collection was conducted as individual interviews with a narrative approach, and data were analyzed with phenomenological hermeneutic interpretation. The participants did not think they would get critically ill with this unexpected illness. They experienced terrible nightmares where their relatives had been killed, and they missed their relatives both in their dreams and in reality, as they had not been allowed to be with them due to the virus. Gratefulness was described for surviving. Participants described thoughts of not being able to imagine going through this again. They felt fear and loneliness, as a terrifying unreality had become a reality.", "doi": "10.1177/10497323211050048", "pmid": "34839759", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T18:12:43.579Z", "modified": "2021-12-18T18:12:43.660Z"}, {"entity": "publication", "iuid": "41d9d59911dd4b5cbb0b4bf1de8af240", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41d9d59911dd4b5cbb0b4bf1de8af240.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41d9d59911dd4b5cbb0b4bf1de8af240"}}, "title": "Patients diagnosed with COVID-19 and treated with anakinra: a real-world study in the USA.", "authors": [{"family": "Rich", "given": "Carly", "initials": "C", "orcid": "0000-0003-4717-5855", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07ef31d5e3c64104813c74bdebd028c9.json"}}, {"family": "Eriksson", "given": "Daniel", "initials": "D"}, {"family": "Dolfi", "given": "Fabrizio", "initials": "F"}, {"family": "Jablonska", "given": "Katarzyna", "initials": "K"}, {"family": "Dabbous", "given": "Firas", "initials": "F"}, {"family": "Nazir", "given": "Jameel", "initials": "J"}], "type": "journal article", "published": "2021-11-27", "journal": {"title": "Clin Exp Immunol", "issn": "1365-2249", "issn-l": null}, "abstract": "Anakinra, a recombinant, non-glycosylated human interleukin (IL)-1 receptor antagonist, has been used in real-world clinical practice to manage hyperinflammation in COVID-19. This retrospective, observational study analyses USA hospital inpatient data of patients diagnosed with moderate/severe COVID-19 and treated with anakinra between 1 April and 31 August 2020. Of the 119 patients included in the analysis, 63.9% were male, 48.6% were of black ethnicity and the mean (standard deviation [SD]) age was 64.7 (12.5) years. Mean (SD) time from hospital admission to anakinra initiation was 7.3 (6.1) days. Following anakinra initiation, 73.1% of patients received antibiotics, 55.5% received antithrombotics, and 91.0% received corticosteroids. Overall, 64.7% of patients required intensive care unit (ICU) admittance, and 28.6% received mechanical ventilation following admission. Patients who did not require ICU admittance or who were discharged alive experienced a significantly shorter time between hospital admission and receiving anakinra treatment compared with those admitted to the ICU (5 vs 8 days; p = 0.002) or those who died in hospital (6 vs 9 days; p = 0.01). Patients with myocardial infarction or renal conditions were six times (p < 0.01) and three times (p = 0.01), respectively, more likely to die in hospital than be discharged alive. A longer time from hospital admission until anakinra treatment was associated with significantly higher mortality (p = 0.01). Findings from this real-world study suggest that a shorter time from hospital admission to anakinra treatment is associated with significantly lower ICU admissions and mortality among patients with moderate/severe COVID-19.", "doi": "10.1093/cei/uxab024", "pmid": "35020840", "labels": {"Category: Drug Discovery": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6445008"}], "notes": [], "created": "2022-01-13T20:56:01.552Z", "modified": "2022-01-13T20:56:01.634Z"}, {"entity": "publication", "iuid": "877c283b6bc944c2b65464cc5278954a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/877c283b6bc944c2b65464cc5278954a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/877c283b6bc944c2b65464cc5278954a"}}, "title": "COVID-19 and myocardial infarction - Authors' reply.", "authors": [{"family": "Katsoularis", "given": "Ioannis", "initials": "I"}, {"family": "Fonseca-Rodr\u00edguez", "given": "Osvaldo", "initials": "O"}, {"family": "Farrington", "given": "Paddy", "initials": "P"}, {"family": "Lindmark", "given": "Krister", "initials": "K"}, {"family": "Connolly", "given": "Anne-Marie Fors", "initials": "AF"}], "type": "letter", "published": "2021-11-27", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "398", "issue": "10315", "pages": "1964", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(21)02320-5", "pmid": "34838176", "labels": {"Type: Other": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8616566"}, {"db": "pii", "key": "S0140-6736(21)02320-5"}], "notes": [], "created": "2021-12-18T18:12:54.982Z", "modified": "2023-06-19T14:47:25.471Z"}, {"entity": "publication", "iuid": "978bd8de884f43a484e720b400afd240", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/978bd8de884f43a484e720b400afd240.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/978bd8de884f43a484e720b400afd240"}}, "title": "A multitask transfer learning framework for the prediction of virus-human protein-protein interactions.", "authors": [{"family": "Dong", "given": "Thi Ngan", "initials": "TN", "orcid": "0000-0002-3240-9068", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac25fc1b1e684ea8bfb683a927e62de0.json"}}, {"family": "Brogden", "given": "Graham", "initials": "G"}, {"family": "Gerold", "given": "Gisa", "initials": "G"}, {"family": "Khosla", "given": "Megha", "initials": "M"}], "type": "journal article", "published": "2021-11-27", "journal": {"title": "BMC Bioinformatics", "issn": "1471-2105", "volume": "22", "issue": "1", "pages": "572", "issn-l": null}, "abstract": "Viral infections are causing significant morbidity and mortality worldwide. Understanding the interaction patterns between a particular virus and human proteins plays a crucial role in unveiling the underlying mechanism of viral infection and pathogenesis. This could further help in prevention and treatment of virus-related diseases. However, the task of predicting protein-protein interactions between a new virus and human cells is extremely challenging due to scarce data on virus-human interactions and fast mutation rates of most viruses.\n\nWe developed a multitask transfer learning approach that exploits the information of around 24 million protein sequences and the interaction patterns from the human interactome to counter the problem of small training datasets. Instead of using hand-crafted protein features, we utilize statistically rich protein representations learned by a deep language modeling approach from a massive source of protein sequences. Additionally, we employ an additional objective which aims to maximize the probability of observing human protein-protein interactions. This additional task objective acts as a regularizer and also allows to incorporate domain knowledge to inform the virus-human protein-protein interaction prediction model.\n\nOur approach achieved competitive results on 13 benchmark datasets and the case study for the SARS-COV-2 virus receptor. Experimental results show that our proposed model works effectively for both virus-human and bacteria-human protein-protein interaction prediction tasks. We share our code for reproducibility and future research at https://git.l3s.uni-hannover.de/dong/multitask-transfer .", "doi": "10.1186/s12859-021-04484-y", "pmid": "34837942", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12859-021-04484-y"}, {"db": "pmc", "key": "PMC8626732"}], "notes": [], "created": "2021-12-18T18:13:13.723Z", "modified": "2021-12-18T18:13:13.776Z"}, {"entity": "publication", "iuid": "461999d72d1b4338a4999a7334412c17", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/461999d72d1b4338a4999a7334412c17.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/461999d72d1b4338a4999a7334412c17"}}, "title": "Post-Translational Modification of HMGB1 Disulfide Bonds in Stimulating and Inhibiting Inflammation.", "authors": [{"family": "Andersson", "given": "Ulf", "initials": "U", "orcid": "0000-0003-0316-3860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee9bbcb5111f446e99ff8b68c4027f5c.json"}}, {"family": "Tracey", "given": "Kevin J", "initials": "KJ"}, {"family": "Yang", "given": "Huan", "initials": "H"}], "type": "journal article", "published": "2021-11-26", "journal": {"title": "Cells", "issn": "2073-4409", "volume": "10", "issue": "12", "issn-l": null}, "abstract": "High mobility group box 1 protein (HMGB1), a highly conserved nuclear DNA-binding protein, is a \"damage-associated molecular pattern\" molecule (DAMP) implicated in both stimulating and inhibiting innate immunity. As reviewed here, HMGB1 is an oxidation-reduction sensitive DAMP bearing three cysteines, and the post-translational modification of these residues establishes its proinflammatory and anti-inflammatory activities by binding to different extracellular cell surface receptors. The redox-sensitive signaling mechanisms of HMGB1 also occupy an important niche in innate immunity because HMGB1 may carry other DAMPs and pathogen-associated molecular pattern molecules (PAMPs). HMGB1 with DAMP/PAMP cofactors bind to the receptor for advanced glycation end products (RAGE) which internalizes the HMGB1 complexes by endocytosis for incorporation in lysosomal compartments. Intra-lysosomal HMGB1 disrupts lysosomal membranes thereby releasing the HMGB1-transported molecules to stimulate cytosolic sensors that mediate inflammation. This HMGB1-DAMP/PAMP cofactor pathway slowed the development of HMGB1-binding antagonists for diagnostic or therapeutic use. However, recent discoveries that HMGB1 released from neurons mediates inflammation via the TLR4 receptor system, and that cancer cells express fully oxidized HMGB1 as an immunosuppressive mechanism, offer new paths to targeting HMGB1 for inflammation, pain, and cancer.", "doi": "10.3390/cells10123323", "pmid": "34943830", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "cells10123323"}, {"db": "pmc", "key": "PMC8699546"}], "notes": [], "created": "2022-01-03T15:35:56.729Z", "modified": "2022-01-03T15:35:56.782Z"}, {"entity": "publication", "iuid": "abc9c029bee04f64b31151f71dd181fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abc9c029bee04f64b31151f71dd181fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abc9c029bee04f64b31151f71dd181fa"}}, "title": "COVID-19-specific metabolic imprint yields insights into multiorgan system perturbations.", "authors": [{"family": "Cornillet", "given": "Martin", "initials": "M"}, {"family": "Strunz", "given": "Benedikt", "initials": "B"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Ponzetta", "given": "Andrea", "initials": "A"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Muvva", "given": "Jagadeeswara Rao", "initials": "JR"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Chambers", "given": "Benedict J", "initials": "BJ"}, {"family": "Dzidic", "given": "Majda", "initials": "M"}, {"family": "Filipovic", "given": "Iva", "initials": "I"}, {"family": "Gorin", "given": "Jean-Baptiste", "initials": "JB"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Hertwig", "given": "Laura", "initials": "L"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Kokkinou", "given": "Efthymia", "initials": "E"}, {"family": "Kvedaraite", "given": "Egle", "initials": "E"}, {"family": "Lourda", "given": "Magda", "initials": "M"}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J"}, {"family": "Maucourant", "given": "Christopher", "initials": "C"}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A"}, {"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Perez-Potti", "given": "Andr\u00e9", "initials": "A"}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Sandberg", "given": "John Tyler", "initials": "JT"}, {"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "Svensson", "given": "Mattias", "initials": "M"}, {"family": "Varnaite", "given": "Renata", "initials": "R"}, {"family": "Karolinska KI/K COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4691d38f3268433696d7c65ea235a12b.json"}}], "type": "journal article", "published": "2021-11-26", "journal": {"title": "Eur J Immunol", "issn": "1521-4141", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Corona disease 2019 (COVID-19) affects multiple organ systems. Recent studies have indicated perturbations in the circulating metabolome linked to COVID-19 severity. However, several questions pertain with respect to the metabolome in COVID-19. We performed an in-depth assessment of 1129 unique metabolites in 27 hospitalized COVID-19 patients and integrated results with large-scale proteomic and immunology data to capture multiorgan system perturbations. More than half of the detected metabolic alterations in COVID-19 were driven by patient-specific confounding factors ranging from comorbidities to xenobiotic substances. Systematically adjusting for this, a COVID-19-specific metabolic imprint was defined which, over time, underwent a switch in response to severe acute respiratory syndrome coronavirus-2 seroconversion. Integration of the COVID-19 metabolome with clinical, cellular, molecular, and immunological severity scales further revealed a network of metabolic trajectories aligned with multiple pathways for immune activation, and organ damage including neurological inflammation and damage. Altogether, this resource refines our understanding of the multiorgan system perturbations in severe COVID-19 patients.", "doi": "10.1002/eji.202149626", "pmid": "34837225", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null}, "xrefs": [{"db": "URL", "key": "http://www.covid19cellatlas.com", "description": "http://www.covid19cellatlas.com"}], "notes": [], "created": "2021-11-29T06:50:01.953Z", "modified": "2022-02-14T14:51:25.826Z"}, {"entity": "publication", "iuid": "d57da8e8898541a99e1eb3eeec229a67", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d57da8e8898541a99e1eb3eeec229a67.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d57da8e8898541a99e1eb3eeec229a67"}}, "title": "Working conditions in the long-term care sector: A comparative study of migrant and native workers in Austria and Sweden.", "authors": [{"family": "Simmons", "given": "Cassandra", "initials": "C", "orcid": "0000-0002-3053-4244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d023b23170f4381b3b56e2d0299760c.json"}}, {"family": "Rodrigues", "given": "Ricardo", "initials": "R", "orcid": "0000-0001-8438-4184", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93f762464a28446cadf03fe7c1f3a744.json"}}, {"family": "Szebehely", "given": "Marta", "initials": "M", "orcid": "0000-0001-6956-7329", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f91b8962e79467695591ce7db084b3d.json"}}], "type": "journal article", "published": "2021-11-25", "journal": {"title": "Health Soc Care Community", "issn": "1365-2524", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Increased demand for long-term care (LTC) services alongside precarious working conditions has resulted in labour shortages in the LTC sector, which has led to an increasing share of workers of migrant origin filling these jobs. Previous research on migrant care workers has also highlighted the seeming gap in working conditions relative to native workers. However, lack of disaggregated data on migrant and native care workers, alongside single-case studies, may have concealed potential disadvantages faced by certain groups and insufficiently accounted for differences in migration regimes and organisation of LTC sectors. To address these gaps, we carried out a comparative study on various working conditions of migrant and native LTC workers in Austria and Sweden. Using the international Nordcare survey on care sector working conditions, carried out in Austria in 2017 (n = 792) and in Sweden in 2015 (n = 708), we employed t-tests and multivariate logistic regressions to compare the working conditions of migrant and native carers in home and residential care in each country. We found that worse working conditions in Sweden compared to Austria may be explained by differences in training requirements of the LTC workforce and the relatively large for-profit private sector. Country of origin also plays a paramount role in the differences in working conditions experienced by migrants compared to native care workers, with non-European migrants being more likely to face a number of precarious working conditions. Our findings highlight the need to continue addressing precarious working conditions across the sector, particularly during the COVID-19 pandemic where poor working conditions have been linked to increased COVID-related deaths in nursing homes. Our findings also emphasise the importance of policies that consider the various challenges experienced by different migrant groups in the LTC sector, who may particularly be at risk of presenteeism during the COVID-19 pandemic.", "doi": "10.1111/hsc.13657", "pmid": "34825423", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T18:18:50.075Z", "modified": "2022-11-22T05:45:43.886Z"}, {"entity": "publication", "iuid": "7a72853feee044088b4630148605d8f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a72853feee044088b4630148605d8f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a72853feee044088b4630148605d8f8"}}, "title": "Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome.", "authors": [{"family": "Masood", "given": "Kiran Iqbal", "initials": "KI"}, {"family": "Yameen", "given": "Maliha", "initials": "M"}, {"family": "Ashraf", "given": "Javeria", "initials": "J"}, {"family": "Shahid", "given": "Saba", "initials": "S"}, {"family": "Mahmood", "given": "Syed Faisal", "initials": "SF"}, {"family": "Nasir", "given": "Asghar", "initials": "A"}, {"family": "Nasir", "given": "Nosheen", "initials": "N"}, {"family": "Jamil", "given": "Bushra", "initials": "B"}, {"family": "Ghanchi", "given": "Najia Karim", "initials": "NK"}, {"family": "Khanum", "given": "Iffat", "initials": "I"}, {"family": "Razzak", "given": "Safina Abdul", "initials": "SA"}, {"family": "Kanji", "given": "Akbar", "initials": "A"}, {"family": "Hussain", "given": "Rabia", "initials": "R"}, {"family": "E Rottenberg", "given": "Martin", "initials": "M"}, {"family": "Hasan", "given": "Zahra", "initials": "Z"}], "type": "journal article", "published": "2021-11-25", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "22958", "issn-l": "2045-2322"}, "abstract": "Understanding key host protective mechanisms against SARS-CoV-2 infection can help improve treatment modalities for COVID-19. We used a blood transcriptome approach to study biomarkers associated with differing severity of COVID-19, comparing severe and mild Symptomatic disease with Asymptomatic COVID-19 and uninfected Controls. There was suppression of antigen presentation but upregulation of inflammatory and viral mRNA translation associated pathways in Symptomatic as compared with Asymptomatic cases. In severe COVID-19, CD177 a neutrophil marker, was upregulated while interferon stimulated genes (ISGs) were downregulated. Asymptomatic COVID-19 cases displayed upregulation of ISGs and humoral response genes with downregulation of ICAM3 and TLR8. Compared across the COVID-19 disease spectrum, we found type I interferon (IFN) responses to be significantly upregulated (IFNAR2, IRF2BP1, IRF4, MAVS, SAMHD1, TRIM1), or downregulated (SOCS3, IRF2BP2, IRF2BPL) in Asymptomatic as compared with mild and severe COVID-19, with the dysregulation of an increasing number of ISGs associated with progressive disease. These data suggest that initial early responses against SARS-CoV-2 may be effectively controlled by ISGs. Therefore, we hypothesize that treatment with type I interferons in the early stage of COVID-19 may limit disease progression by limiting SARS-CoV-2 in the host.", "doi": "10.1038/s41598-021-02489-4", "pmid": "34824360", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-02489-4"}, {"db": "pmc", "key": "PMC8617268"}], "notes": [], "created": "2021-12-18T18:19:04.143Z", "modified": "2021-12-18T18:19:04.157Z"}, {"entity": "publication", "iuid": "2d5318adb0dd496d8f88c3835268cc12", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d5318adb0dd496d8f88c3835268cc12.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d5318adb0dd496d8f88c3835268cc12"}}, "title": "Thrombosis and Bleeding After Implementation of an Intermediate-Dose Prophylactic Anticoagulation Protocol in ICU Patients With COVID-19: A Multicenter Screening Study.", "authors": [{"family": "Al-Abani", "given": "Kais", "initials": "K", "orcid": "0000-0002-1789-1538", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a63c8ea9d2b4263817a82795ff41e55.json"}}, {"family": "Kilhamn", "given": "Naima", "initials": "N", "orcid": "0000-0002-7797-9558", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4eef69c580c944989ee65bdf7a0cdb06.json"}}, {"family": "Maret", "given": "Eva", "initials": "E"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J", "orcid": "0000-0001-8739-7896", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c2fb174ab842c8809900877de8c008.json"}}], "type": "journal article", "published": "2021-11-25", "journal": {"title": "J Intensive Care Med", "issn": "1525-1489", "pages": "8850666211051960", "issn-l": null}, "abstract": "Thrombosis and bleeding after implementation of an intermediate-dose prophylactic anticoagulation protocol in intensive care unit (ICU) patients with coronavirus disease 2019 (COVID-19): a multicenter screening study Background: Venous thromboembolism (VTE) is common among critically ill patients with COVID-19. Information regarding VTE prevalence and bleeding complications after implementation of intermediate-dose prophylactic anticoagulation in such patients is, however, limited. Methods: We performed a prospective, observational study in 6 ICUs in 2 university-affiliated teaching hospitals in Sweden. After implementation of an intermediate-dose prophylactic anticoagulation protocol, we performed ultrasound screening for proximal lower-extremity deep vein thrombosis (DVT) and collected routine computed tomography pulmonary angiography exam results. Results: A total of 100 COVID-19 patients were included from June 21, 2020, through February 18, 2021. During a median follow-up of 120 (IQR, 89-134) days, we found VTE in 37 patients with the majority (78.4%) being diagnosed after ICU arrival. Overall, 20 patients had proximal lower-extremity DVT with 95% being detected on ultrasound screening; 22 patients had pulmonary vascular thrombosis; and 4 patients had venous thrombosis at other sites. A total of 6 patients had both proximal lower-extremity DVT and pulmonary vascular thrombosis. On univariate logistic regression analysis of 14 baseline characteristics, only pre-existing heart failure was associated with VTE (OR 4.67, 95% CI 1.13-19.34). Major and non-major bleeding occurred in 10 and 18 patients, respectively. Conclusions: In our cohort of ICU patients with COVID-19, we observed a high prevalence of VTE and bleeding complications after implementation of intermediate-dose anticoagulation. In approximately half of patients, VTE was identified on screening ultrasound.", "doi": "10.1177/08850666211051960", "pmid": "34821162", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T13:05:15.915Z", "modified": "2021-12-18T18:20:59.763Z"}, {"entity": "publication", "iuid": "e782f8c5f6f74285a6d78de609f94e64", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e782f8c5f6f74285a6d78de609f94e64.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e782f8c5f6f74285a6d78de609f94e64"}}, "title": "Associations between compliance with covid-19 public health recommendations and perceived contagion in others: a self-report study in Swedish university students.", "authors": [{"family": "Andersson", "given": "Claes", "initials": "C", "orcid": "0000-0001-9819-2474", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2dce70574f549a6badd1af98fad130a.json"}}, {"family": "Bendtsen", "given": "Marcus", "initials": "M"}, {"family": "Molander", "given": "Olof", "initials": "O"}, {"family": "Granlund", "given": "Lilian", "initials": "L"}, {"family": "Topooco", "given": "Naira", "initials": "N"}, {"family": "Engstr\u00f6m", "given": "Karin", "initials": "K"}, {"family": "Lindfors", "given": "Petra", "initials": "P"}, {"family": "Berman", "given": "Anne H", "initials": "AH"}], "type": "journal article", "published": "2021-11-25", "journal": {"title": "BMC Res Notes", "issn": "1756-0500", "volume": "14", "issue": "1", "pages": "429", "issn-l": null}, "abstract": "During the COVID pandemic, government authorities worldwide have tried to limit the spread of the virus. Sweden's distinctive feature was the use of voluntary public health recommendations. Few studies have evaluated the effectiveness of this strategy. Based on data collected in the spring of 2020, this study explored associations between compliance with recommendations and observed symptoms of contagion in others, using self-report data from university students.\n\nCompliance with recommendations ranged between 69.7 and 95.7 percent. Observations of moderate symptoms of contagion in \"Someone else I have had contact with\" and \"Another person\" were markedly associated with reported self-quarantine, which is the most restrictive recommendation, complied with by 81.2% of participants. Uncertainty regarding the incidence and severity of contagion in cohabitants was markedly associated with the recommendation to avoid public transportation, a recommendation being followed by 69.7%. It is concluded that students largely followed the voluntary recommendations implemented in Sweden, suggesting that coercive measures were not necessary. Compliance with recommendations were associated with the symptoms students saw in others, and with the perceived risk of contagion in the student's immediate vicinity. It is recommended that voluntary recommendations should stress personal relevance, and that close relatives are at risk.", "doi": "10.1186/s13104-021-05848-6", "pmid": "34823585", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8613723"}, {"db": "pii", "key": "10.1186/s13104-021-05848-6"}], "notes": [], "created": "2021-11-26T13:04:20.837Z", "modified": "2023-06-19T14:24:54.892Z"}, {"entity": "publication", "iuid": "d50564289b6b497dbcea278b78f1c958", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d50564289b6b497dbcea278b78f1c958.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d50564289b6b497dbcea278b78f1c958"}}, "title": "The Paradox of Political Accountability and Deficits in the Preconditions for Service Delivery in Elderly Care: A Qualitative Study of Swedish Politicians", "authors": [{"family": "Porter", "given": "Susann", "initials": "S"}, {"family": "Muhonen", "given": "Tuija", "initials": "T"}], "type": "journal-article", "published": "2021-11-24", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "23", "pages": "12350", "issn-l": null}, "abstract": null, "doi": "10.3390/ijerph182312350", "pmid": null, "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:56:32.225Z", "modified": "2021-12-12T06:56:32.244Z"}, {"entity": "publication", "iuid": "032f79d2b198402daefeca79ebaacd96", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/032f79d2b198402daefeca79ebaacd96.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/032f79d2b198402daefeca79ebaacd96"}}, "title": "Impact of the Covid-19 pandemic on primary care utilization: evidence from Sweden using national register data.", "authors": [{"family": "Ekman", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0001-7630-7904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1f4d8ed39cc483a802c179c1f37c53d.json"}}, {"family": "Arvidsson", "given": "Eva", "initials": "E"}, {"family": "Thulesius", "given": "Hans", "initials": "H"}, {"family": "Wilkens", "given": "Jens", "initials": "J"}, {"family": "Cronberg", "given": "Olof", "initials": "O"}], "type": "journal article", "published": "2021-11-24", "journal": {"title": "BMC Res Notes", "issn": "1756-0500", "volume": "14", "issue": "1", "pages": "424", "issn-l": null}, "abstract": "To analyze changes in primary care utilization as a result of the Covid-19 pandemic. Swedish national register data from 2019 to 2020 on utilization of services were used to compare overall utilization levels and across types of contacts and patient groups. A specific objective was to assess the extent to which remote types of patient consultations were able to compensate for any observed fall in on-site visits. Data were stratified by sex and age to investigate any demographic pattern.\n\nFindings show significant reductions in overall utilization of services as the pandemic occurred in the first quarter of 2020. On-site visits fell during the first wave of the pandemic and rebounded thereafter. Patients over 65 years of age appear to have reduced utilization to a larger extent compared with younger groups. Simultaneously, remote contacts increased from around 12% before the pandemic to 17% of the total number of consultations. However, the net effect of changes in service utilization suggests an overall reduction of around 12 percent in the number of primary care consultations as a result of the pandemic. No differences between men and women were observed. Further research will continue to monitor changes in primary care utilization as the pandemic continues.", "doi": "10.1186/s13104-021-05839-7", "pmid": "34819161", "labels": {"Type: Journal article": null, "Topics: Register-based research": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13104-021-05839-7"}, {"db": "pmc", "key": "PMC8611625"}], "notes": [], "created": "2021-11-26T13:05:55.405Z", "modified": "2021-12-18T18:21:41.694Z"}, {"entity": "publication", "iuid": "f11c8ef92e004250bd551f84fd6c7803", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f11c8ef92e004250bd551f84fd6c7803.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f11c8ef92e004250bd551f84fd6c7803"}}, "title": "The impact of COVID-19 on cancer care and oncology clinical research: an experts' perspective.", "authors": [{"family": "Sessa", "given": "C", "initials": "C"}, {"family": "Cortes", "given": "J", "initials": "J"}, {"family": "Conte", "given": "P", "initials": "P"}, {"family": "Cardoso", "given": "F", "initials": "F"}, {"family": "Choueiri", "given": "T", "initials": "T"}, {"family": "Dummer", "given": "R", "initials": "R"}, {"family": "Lorusso", "given": "P", "initials": "P"}, {"family": "Ottmann", "given": "O", "initials": "O"}, {"family": "Ryll", "given": "B", "initials": "B"}, {"family": "Mok", "given": "T", "initials": "T"}, {"family": "Tempero", "given": "M", "initials": "M"}, {"family": "Comis", "given": "S", "initials": "S"}, {"family": "Oliva", "given": "C", "initials": "C"}, {"family": "Peters", "given": "S", "initials": "S"}, {"family": "Tabernero", "given": "J", "initials": "J"}], "type": "journal article", "published": "2021-11-23", "journal": {"title": "ESMO Open", "issn": "2059-7029", "volume": "7", "issue": "1", "pages": "100339", "issn-l": null}, "abstract": "The coronavirus disease-19 (COVID-19) pandemic promises to have lasting impacts on cancer clinical trials that could lead to faster patient access to new treatments. In this article, an international panel of oncology experts discusses the lasting impacts of the pandemic on oncology clinical trials and proposes solutions for clinical trial stakeholders, with the support of recent data on worldwide clinical trials collected by IQVIA. These lasting impacts and proposed solutions encompass three topic areas. Firstly, acceleration and implementation of new operational approaches to oncology trials with patient-centric, fully decentralized virtual approaches that include remote assessments via telemedicine and remote devices. Geographical differences in the uptake of remote technology, including telemedicine, are discussed in the article, focusing on the impact of the local adoption of new operational approaches. Secondly, innovative clinical trials. The pandemic has highlighted the need for new trial designs that accelerate research and limit risks and burden for patients while driving optimization of clinical trial objectives and endpoints, while testing is being minimized. Areas of considerations for clinical trial stakeholders are discussed in detail. In addition, the COVID-19 pandemic has exposed the underrepresentation of minority groups in clinical trials; the approach for oncology clinical trials to improve generalizability of efficacy and outcomes data is discussed. Thirdly, a new problem-focused collaborative framework between oncology trial stakeholders, including decision makers, to leverage and further accelerate the innovative approaches in clinical research developed during the COVID-19 pandemic. This could shorten timelines for patient access to new treatments by addressing the cultural and technological barriers to adopting new operational approaches and innovative clinical trials. The role of the different stakeholders is described, with the aim of making COVID-19 a catalyst for positive change in oncology clinical research and eventually in cancer care.", "doi": "10.1016/j.esmoop.2021.100339", "pmid": "34953404", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2059-7029(21)00301-X"}, {"db": "pmc", "key": "PMC8608656"}], "notes": [], "created": "2022-01-04T15:25:35.957Z", "modified": "2022-01-04T15:25:35.963Z"}, {"entity": "publication", "iuid": "e67e39136bfb4bfbb52f5866da426b32", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e67e39136bfb4bfbb52f5866da426b32.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e67e39136bfb4bfbb52f5866da426b32"}}, "title": "Self-scored impairments in functioning and disability in post-COVID syndrome following mild COVID-19 infection.", "authors": [{"family": "Norrefalk", "given": "Jan-Rickard", "initials": "JR", "orcid": "0000-0002-7070-3268", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24718b50907344ec9053bfc5d8495f19.json"}}, {"family": "Borg", "given": "Kristian", "initials": "K"}, {"family": "Bileviciute-Ljungar", "given": "Indre", "initials": "I"}], "type": "journal article", "published": "2021-11-23", "journal": {"title": "J Rehabil Med", "issn": "1651-2081", "issn-l": null, "volume": "53", "issue": "11 (November)", "pages": "jrm00239"}, "abstract": "To investigate functioning, activity and disability in people with post-COVID syndrome.\n\nCross-sectional.\n\nParticipants were recruited online via Facebook and a stakeholders' organization for post-COVID syndrome in Sweden.\n\nSociodemographic data and International Classification of Functioning, Disability and Health (ICF)-based questionnaire were collected via an online platform and analysed.\n\nA total of 100 participants were included (mean age 44.5 years, 82% women, 61% with higher education, and 56% working full- or part-time). For the ICF component Body Functions, the most impaired functions were: fatigability and energy drive (98-99%); higher cognitive functions (74-94%); sleep functions (98%); muscle functions (93%); respiratory functions (92%); heart functions (82%); emotional functions (80%); sexual functions (77%); pain problems (56-90%); and thermoregulatory functions (68%). For the component Activity, the most frequent limitations were: handling stressful situations (98%); remunerative employment (95%); recreation and leisure (94%); climbing the stairs (94%); doing housework (84%); and informal socializing (64%). The most frequent degrees of impairment/limitations were light and moderate, except for severe-complete for fatigue, higher cognitive functions, multitasking, handling stressful situations; and recreation and leisure activities.\n\nPost-COVID syndrome following a mild COVID-19 infection can result in impaired body functions and activities. These results support the importance of a multidisciplinary rehabilitation approach for these patients.", "doi": "10.2340/jrm.v53.188", "pmid": "34643243", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC8638742"}], "notes": [], "created": "2021-10-21T05:08:19.835Z", "modified": "2023-06-19T15:16:57.208Z"}, {"entity": "publication", "iuid": "2864668bd1e647ecbd7fe29293402ec6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2864668bd1e647ecbd7fe29293402ec6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2864668bd1e647ecbd7fe29293402ec6"}}, "title": "Risk of severe COVID-19 and mortality in patients with established chronic liver disease: a nationwide matched cohort study.", "authors": [{"family": "Simon", "given": "Tracey G", "initials": "TG"}, {"family": "Hagstr\u00f6m", "given": "Hannes", "initials": "H"}, {"family": "Sharma", "given": "Rajani", "initials": "R"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Roelstraete", "given": "Bjorn", "initials": "B"}, {"family": "Larsson", "given": "Emma", "initials": "E"}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "journal article", "published": "2021-11-23", "journal": {"title": "BMC Gastroenterol", "issn": "1471-230X", "volume": "21", "issue": "1", "pages": "439", "issn-l": null}, "abstract": "Some, but not all, prior studies have suggested that patients with chronic liver disease are at increased risk of contracting COVID-19 and developing more severe disease. However, nationwide data are lacking from well-phenotyped cohorts with liver histology and comparisons to matched general population controls.\n\nWe conducted a nationwide cohort study of all Swedish adults with chronic liver disease (CLD) confirmed by liver biopsy between 1966 and 2017 (n = 42,320), who were alive on February 1, 2020. CLD cases were matched to \u2264 5 population comparators by age, sex, calendar year and county (n = 182,147). Using Cox regression, we estimated multivariable-adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for COVID-19 hospitalization and severe COVID-19 (intensive care admission or death due to COVID-19).\n\nBetween February 1 and July 31, 2020, 161 (0.38%) CLD patients and 435 (0.24%) general population controls were hospitalized with COVID-19 (aHR = 1.36, 95% CI = 1.11-1.66), while 65 (0.15%) CLD patients and 191 (0.10%) controls developed severe COVID-19 (aHR = 1.08, 95% CI = 0.79-1.48). Results were similar in patients with CLD due to alcohol use, nonalcoholic fatty liver disease, viral hepatitis, autoimmune hepatitis, and other etiologies. Among patients with cirrhosis (n = 2549), the aHRs for COVID-19 hospitalization and for severe COVID-19 were 1.08 (95% CI 0.48-2.40) and 1.23 (95% CI = 0.37-4.04), respectively, compared to controls. Moreover, among all patients diagnosed with COVID-19, the presence of underlying CLD was not associated with increased mortality (aHR = 0.85, 95% CI = 0.61-1.19).\n\nIn this nationwide cohort, patients with CLD had a higher risk of hospitalization for COVID-19 compared to the general population, but they did not have an increased risk of developing severe COVID-19.", "doi": "10.1186/s12876-021-02017-8", "pmid": "34814851", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12876-021-02017-8"}, {"db": "pmc", "key": "PMC8609512"}], "notes": [], "created": "2021-11-26T13:18:35.808Z", "modified": "2021-12-10T19:35:57.119Z"}, {"entity": "publication", "iuid": "35aa3cd093fd45d89865f8821d247ed6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/35aa3cd093fd45d89865f8821d247ed6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/35aa3cd093fd45d89865f8821d247ed6"}}, "title": "Changes in young adults' mental well-being before and during the early stage of the COVID-19 pandemic: disparities between ethnic groups in Germany.", "authors": [{"family": "Plenty", "given": "Stephanie", "initials": "S", "orcid": "0000-0001-7994-4829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4ecdc074a5e4829a9938e329048169c.json"}}, {"family": "Bracegirdle", "given": "Chloe", "initials": "C"}, {"family": "Dollmann", "given": "J\u00f6rg", "initials": "J"}, {"family": "Spiegler", "given": "Olivia", "initials": "O"}], "type": "journal article", "published": "2021-11-23", "journal": {"title": "Child Adolesc Psychiatry Ment Health", "issn": "1753-2000", "volume": "15", "issue": "1", "pages": "69", "issn-l": null}, "abstract": "The COVID-19 pandemic resulted in substantial disruptions to the daily lives of young people. Yet knowledge is lacking about changes in mental well-being among young adults, whether those from ethnic minorities were more adversely impacted by the pandemic than the ethnic majority, and the extent to which pandemic-related stressors contributed to any declines in mental well-being.\n\nWe draw on nationally representative German CILS4COVID data, collected early in the pandemic (N = 3517, Mage = 25). Respondents provided information on mental well-being (psychosomatic complaints, anxiety, depression, life satisfaction) and exposure to pandemic-related stressors (financial worries, health worries, discrimination, contact with COVID-19). Responses on mental well-being were matched to responses from two pre-pandemic waves. Individual fixed effects regressions examined ethnic group differences in changes in mental well-being prior to, and at the early stage of, the pandemic. Path analysis tested the role of pandemic-related stressors in declines in mental well-being.\n\nOverall, young adults' mental well-being had improved at the pandemic assessment compared to pre-pandemic assessments, and few ethnic group differences in changes were found. However, greater pandemic-related stressors were associated with worsened mental well-being at the pandemic assessment. Among Asian minorities, indirect effects were found on anxiety via health worries, and on depression via health worries and discrimination. For Turkish, Middle Eastern and African minorities, indirect effects on anxiety and depression were found via health worries.\n\nWe did not find widespread declines in mental well-being among young adults at the early stage of the pandemic, and changes in mental well-being prior to and at the early stage of the pandemic were mostly similar across ethnic German and minority groups. Nevertheless, pandemic-related stressors posed risks for young adults' mental well-being, particularly increased discrimination and health worries among Asian minorities, and health worries among Turkish, Middle Eastern and African minorities.", "doi": "10.1186/s13034-021-00418-x", "pmid": "34814926", "labels": {"Type: Journal article": null, "Topics: Register-based research": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13034-021-00418-x"}, {"db": "pmc", "key": "PMC8609988"}], "notes": [], "created": "2021-11-26T13:17:39.305Z", "modified": "2021-12-18T18:23:44.625Z"}, {"entity": "publication", "iuid": "d1fc8ca94c4b47b8ad6d10438d522bb7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1fc8ca94c4b47b8ad6d10438d522bb7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1fc8ca94c4b47b8ad6d10438d522bb7"}}, "title": "COVID-19 Vaccine Hesitancy in the United States: A Systematic Review", "authors": [{"family": "Yasmin", "given": "Farah", "initials": "F"}, {"family": "Najeeb", "given": "Hala", "initials": "H"}, {"family": "Moeed", "given": "Abdul", "initials": "A"}, {"family": "Naeem", "given": "Unaiza", "initials": "U"}, {"family": "Asghar", "given": "Muhammad Sohaib", "initials": "MS"}, {"family": "Chughtai", "given": "Najeeb Ullah", "initials": "NU"}, {"family": "Yousaf", "given": "Zohaib", "initials": "Z"}, {"family": "Seboka", "given": "Binyam Tariku", "initials": "BT"}, {"family": "Ullah", "given": "Irfan", "initials": "I"}, {"family": "Lin", "given": "Chung Ying", "initials": "CY"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal-article", "published": "2021-11-23", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2021.770985", "pmid": null, "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:52:36.907Z", "modified": "2021-12-12T06:53:00.510Z"}, {"entity": "publication", "iuid": "c4e922a935614f2084722b199ef6635c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c4e922a935614f2084722b199ef6635c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c4e922a935614f2084722b199ef6635c"}}, "title": "A Genetic Trap in Yeast for Inhibitors of SARS-CoV-2 Main Protease.", "authors": [{"family": "Alalam", "given": "Hanna", "initials": "H"}, {"family": "Sigurdard\u00f3ttir", "given": "Sunniva", "initials": "S"}, {"family": "Bourgard", "given": "Catarina", "initials": "C"}, {"family": "Tiukova", "given": "Ievgeniia", "initials": "I", "orcid": "0000-0002-0408-3515", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b86de4d9336b48daa3cd8cd3d2420573.json"}}, {"family": "King", "given": "Ross D", "initials": "RD"}, {"family": "Gr\u00f8tli", "given": "Morten", "initials": "M", "orcid": "0000-0003-3621-4222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0039e14b21d5401a833de03544270f70.json"}}, {"family": "Sunnerhagen", "given": "Per", "initials": "P", "orcid": "0000-0002-0967-8729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89127120ae8b43bea9681b7eadf1872b.json"}}], "type": "journal article", "published": "2021-11-23", "journal": {"title": "mSystems", "issn": "2379-5077", "pages": "e0108721", "issn-l": null}, "abstract": "The ongoing COVID-19 pandemic urges searches for antiviral agents that can block infection or ameliorate its symptoms. Using dissimilar search strategies for new antivirals will improve our overall chances of finding effective treatments. Here, we have established an experimental platform for screening of small molecule inhibitors of the SARS-CoV-2 main protease in Saccharomyces cerevisiae cells, genetically engineered to enhance cellular uptake of small molecules in the environment. The system consists of a fusion of the Escherichia coli toxin MazF and its antitoxin MazE, with insertion of a protease cleavage site in the linker peptide connecting the MazE and MazF moieties. Expression of the viral protease confers cleavage of the MazEF fusion, releasing the MazF toxin from its antitoxin, resulting in growth inhibition. In the presence of a small molecule inhibiting the protease, cleavage is blocked and the MazF toxin remains inhibited, promoting growth. The system thus allows positive selection for inhibitors. The engineered yeast strain is tagged with a fluorescent marker protein, allowing precise monitoring of its growth in the presence or absence of inhibitor. We detect an established main protease inhibitor by a robust growth increase, discernible down to 1 \u03bcM. The system is suitable for robotized large-scale screens. It allows in vivo evaluation of drug candidates and is rapidly adaptable for new variants of the protease with deviant site specificities. IMPORTANCE The COVID-19 pandemic may continue for several years before vaccination campaigns can put an end to it globally. Thus, the need for discovery of new antiviral drug candidates will remain. We have engineered a system in yeast cells for the detection of small molecule inhibitors of one attractive drug target of SARS-CoV-2, its main protease, which is required for viral replication. The ability to detect inhibitors in live cells brings the advantage that only compounds capable of entering the cell and remain stable there will score in the system. Moreover, because of its design in yeast cells, the system is rapidly adaptable for tuning the detection level and eventual modification of the protease cleavage site in the case of future mutant variants of the SARS-CoV-2 main protease or even for other proteases.", "doi": "10.1128/mSystems.01087-21", "pmid": "34812651", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Funder: VR": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC8609969"}], "notes": [], "created": "2021-11-26T13:20:05.776Z", "modified": "2021-12-10T17:56:45.258Z"}, {"entity": "publication", "iuid": "8b4f25b4edb743179b967a65d0b202dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b4f25b4edb743179b967a65d0b202dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b4f25b4edb743179b967a65d0b202dd"}}, "title": "Population-based study of multisystem inflammatory syndrome associated with COVID-19 found that 36% of children had persistent symptoms.", "authors": [{"family": "Kahn", "given": "Robin", "initials": "R", "orcid": "0000-0002-3167-1179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ac84bfddfbf425bad7a1484aa57414c.json"}}, {"family": "Berg", "given": "Stefan", "initials": "S"}, {"family": "Berntson", "given": "Lillemor", "initials": "L", "orcid": "0000-0003-3962-0453", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56b35f89d1b749b6bb447932384fe4d2.json"}}, {"family": "Berthold", "given": "Elisabet", "initials": "E"}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}, {"family": "B\u00e4ckstr\u00f6m", "given": "Fredrik", "initials": "F"}, {"family": "Compagno", "given": "Michele", "initials": "M"}, {"family": "Fasth", "given": "Anders", "initials": "A", "orcid": "0000-0002-0033-740X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f29cd19b2c7544bb83ce6879ffba2dc6.json"}}, {"family": "Lingman Framme", "given": "Jenny", "initials": "J"}, {"family": "Horne", "given": "AnnaCarin", "initials": "A"}, {"family": "H\u00e4tting", "given": "Josefin", "initials": "J"}, {"family": "Kr\u00f3l", "given": "Petra", "initials": "P"}, {"family": "Kukka", "given": "Antti J", "initials": "AJ"}, {"family": "Mossberg", "given": "Maria", "initials": "M"}, {"family": "M\u00e5nsson", "given": "Bengt", "initials": "B"}, {"family": "Nordenh\u00e4ll", "given": "Charlotta", "initials": "C"}, {"family": "Idring Nordstr\u00f6m", "given": "Selma", "initials": "S"}, {"family": "Khammari Nystr\u00f6m", "given": "Fatine", "initials": "F"}, {"family": "Palmblad", "given": "Karin", "initials": "K"}, {"family": "Rasti", "given": "Reza", "initials": "R"}, {"family": "Rudolph", "given": "Andr\u00e9", "initials": "A"}, {"family": "Rydenman", "given": "Karin", "initials": "K"}, {"family": "Sundberg", "given": "Erik", "initials": "E"}, {"family": "S\u00e4ve-S\u00f6derbergh", "given": "Eva", "initials": "E"}, {"family": "Altman", "given": "Maria", "initials": "M", "orcid": "0000-0001-8316-0154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9efee5220a52450fa208d78ef82a0e20.json"}}], "type": "journal article", "published": "2021-11-22", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253"}, "abstract": "Our aim was to describe the outcomes of multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19.\n\nThis national, population-based, longitudinal, multicentre study used Swedish data that were prospectively collected between 1 December 2020 and 31 May 2021. All patients met the World Health Organization criteria for MIS-C. The outcomes 2 and 8 weeks after diagnosis are presented, and follow-up protocols are suggested.\n\nWe identified 152 cases, and 133 (87%) participated. When followed up 2 weeks after MIS-C was diagnosed, 43% of the 119 patients had abnormal results, including complete blood cell counts, platelet counts, albumin levels, electrocardiograms and echocardiograms. After 8 weeks, 36% of 89 had an abnormal patient history, but clinical findings were uncommon. Echocardiogram results were abnormal in 5% of 67, and the most common complaint was fatigue. Older children and those who received intensive care were more likely to report symptoms and have abnormal cardiac results.\n\nMore than a third (36%) of the patients had persistent symptoms 8 weeks after MIS-C, and 5% had abnormal echocardiograms. Older age and higher levels of initial care appeared to be risk factors. Structured follow-up visits are important after MIS-C.", "doi": "10.1111/apa.16191", "pmid": "34806789", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T13:55:47.806Z", "modified": "2021-12-10T18:07:00.711Z"}, {"entity": "publication", "iuid": "c06d810ebd4b428ea3e8bf99e4f1872c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c06d810ebd4b428ea3e8bf99e4f1872c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c06d810ebd4b428ea3e8bf99e4f1872c"}}, "title": "Influenza outcomes in patients with inflammatory joint diseases and DMARDs: how do they compare to those of COVID-19?", "authors": [{"family": "Bower", "given": "Hannah", "initials": "H", "orcid": "0000-0002-2046-3833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac82ea2714c34d58a762b3cc168cbd4a.json"}}, {"family": "Frisell", "given": "Thomas", "initials": "T", "orcid": "0000-0002-5735-9626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e9d6be8c47b4d6eb80bd3d57a63172e.json"}}, {"family": "Di Giuseppe", "given": "Daniela", "initials": "D"}, {"family": "Delcoigne", "given": "B\u00e9n\u00e9dicte", "initials": "B"}, {"family": "Askling", "given": "Johan", "initials": "J", "orcid": "0000-0003-0433-0616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26359d7da52744208ca84bc65a5401cb.json"}}], "type": "journal article", "published": "2021-11-22", "journal": {"title": "Ann Rheum Dis", "issn": "1468-2060", "issn-l": null}, "abstract": "To estimate absolute and relative risks for seasonal influenza outcomes in patients with inflammatory joint diseases (IJDs) and disease-modifying antirheumatic drugs (DMARDs). To contextualise recent findings on corresponding COVID-19 risks.\n\nUsing Swedish nationwide registers for this cohort study, we followed 116 989 patients with IJD and matched population comparators across four influenza seasons (2015-2019). We quantified absolute risks of hospitalisation and death due to influenza, and compared IJD to comparators via Cox regression. We identified 71 556 patients with IJD on active treatment with conventional synthetic DMARDs and biological disease-modifying antirheumatic drugs (bDMARDs)/targeted synthetic disease-modifying antirheumatic drug (tsDMARDs) at the start of each influenza season, estimated risks for the same outcomes and compared these risks across DMARDs via Cox regression.\n\nPer season, average risks for hospitalisation listing influenza were 0.25% in IJD and 0.1% in the general population, corresponding to a crude HR of 2.38 (95% CI 2.21 to 2.56) that decreased to 1.44 (95% CI 1.33 to 1.56) following adjustments for comorbidities. For death listing influenza, the corresponding numbers were 0.015% and 0.006% (HR=2.63, 95% CI 1.93 to 3.58, and HR=1.46, 95% CI 1.07 to 2.01). Absolute risks for influenza outcomes were half (hospitalisation) and one-tenth (death) of those for COVID-19, but relative estimates comparing IJD to the general population were similar.\n\nIn absolute terms, COVID-19 in IJD outnumbers that of average seasonal influenza, but IJD entails a 50%-100% increase in risk for hospitalisation and death for both types of infections, which is largely dependent on associated comorbidities. Overall, bDMARDs/tsDMARDs do not seem to confer additional risk for hospitalisation or death related to seasonal influenza.", "doi": "10.1136/annrheumdis-2021-221461", "pmid": "34810197", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "annrheumdis-2021-221461"}, {"db": "pmc", "key": "PMC8610614"}], "notes": [], "created": "2021-11-26T13:53:59.516Z", "modified": "2021-12-10T18:04:20.305Z"}, {"entity": "publication", "iuid": "22fb1f7377424f5692811dbdffbf56d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/22fb1f7377424f5692811dbdffbf56d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/22fb1f7377424f5692811dbdffbf56d4"}}, "title": "Functional Antibodies Against SARS-CoV-2 Receptor Binding Domain Variants with Mutations N501Y or E484K in Human Milk from COVID-19-Vaccinated, -Recovered, and -Unvaccinated Women.", "authors": [{"family": "Demers-Mathieu", "given": "Veronique", "initials": "V", "orcid": "0000-0002-7937-6355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db7be05c02af4ba8a72768cd239f1f5e.json"}}, {"family": "Hakansson", "given": "Anders P", "initials": "AP"}, {"family": "Hall", "given": "Stephanie", "initials": "S"}, {"family": "Lavangnananda", "given": "Sirima", "initials": "S"}, {"family": "Fels", "given": "Shawn", "initials": "S"}, {"family": "Medo", "given": "Elena", "initials": "E"}], "type": "journal article", "published": "2021-11-22", "journal": {"title": "Breastfeed Med", "issn": "1556-8342", "issn-l": null}, "abstract": "New variants are evolving in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and receptor binding domain (RBD) mutations have been associated with a higher capacity to evade neutralizing antibodies (NAbs). We aimed at determining the impact of COVID-19 vaccine and infection on human milk antibody titers and activity against the RBD mutations from SARS-CoV-2 variants of concern. Background: Milk samples were collected from 19 COVID-19 vaccinated women, 10 women who had a positive COVID-19 PCR test, and 13 unvaccinated women. The titers and NAbs of secretory IgA (SIgA)/IgA, secretory IgM (IgM)/IgM, and IgG against SARS-CoV-2 RBD with mutations N501Y or E484K were measured by using ELISA and a surrogate virus neutralization assay. Materials and Methods: The titers of human milk IgG against N501Y were higher in the COVID-19 vaccine group than in the no-vaccine group but comparable with the COVID-19 PCR group. Other antibody titers did not differ between the three groups. The titers of SIgA/IgA were higher than those of SIgM/IgM and IgG in all three groups. The titers of SIgM/IgM and the inhibition of NAbs were higher against the mutation E484K than N501Y. Milk NAb did not differ between the three groups, but the inhibition of NAb against binding of the two mutant RBD proteins to their receptor was higher in the COVID-19 vaccine and PCR groups than in milk from prepandemic women. Results: COVID-19 vaccination and exposure of mothers to SARS-CoV-2 influenced the titers and NAbs in breast milk against the variants of concern.Conclusions:", "doi": "10.1089/bfm.2021.0232", "pmid": "34809492", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-11-26T13:54:16.969Z", "modified": "2021-12-10T18:05:02.477Z"}, {"entity": "publication", "iuid": "32657b84d5e64b6791e48042b4c0dbbb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/32657b84d5e64b6791e48042b4c0dbbb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/32657b84d5e64b6791e48042b4c0dbbb"}}, "title": "Drivers and social implications of Artificial Intelligence adoption in healthcare during the COVID-19 pandemic.", "authors": [{"family": "Frank", "given": "Darius-Aurel", "initials": "DA", "orcid": "0000-0002-1577-7352", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0a5cb4ef9514e01a08632ec84866fbf.json"}}, {"family": "Elb\u00e6k", "given": "Christian T", "initials": "CT", "orcid": "0000-0002-7039-4565", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a44f489ddccb4a208ec453424a471bfc.json"}}, {"family": "B\u00f8rsting", "given": "Caroline Kj\u00e6r", "initials": "CK"}, {"family": "Mitkidis", "given": "Panagiotis", "initials": "P"}, {"family": "Otterbring", "given": "Tobias", "initials": "T"}, {"family": "Borau", "given": "Sylvie", "initials": "S"}], "type": "journal article", "published": "2021-11-22", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "11", "pages": "e0259928", "issn-l": "1932-6203"}, "abstract": "The COVID-19 pandemic continues to impact people worldwide-steadily depleting scarce resources in healthcare. Medical Artificial Intelligence (AI) promises a much-needed relief but only if the technology gets adopted at scale. The present research investigates people's intention to adopt medical AI as well as the drivers of this adoption in a representative study of two European countries (Denmark and France, N = 1068) during the initial phase of the COVID-19 pandemic. Results reveal AI aversion; only 1 of 10 individuals choose medical AI over human physicians in a hypothetical triage-phase of COVID-19 pre-hospital entrance. Key predictors of medical AI adoption are people's trust in medical AI and, to a lesser extent, the trait of open-mindedness. More importantly, our results reveal that mistrust and perceived uniqueness neglect from human physicians, as well as a lack of social belonging significantly increase people's medical AI adoption. These results suggest that for medical AI to be widely adopted, people may need to express less confidence in human physicians and to even feel disconnected from humanity. We discuss the social implications of these findings and propose that successful medical AI adoption policy should focus on trust building measures-without eroding trust in human physicians.", "doi": "10.1371/journal.pone.0259928", "pmid": "34807907", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-20575"}, {"db": "pmc", "key": "PMC8608336"}], "notes": [], "created": "2021-11-26T13:55:05.093Z", "modified": "2021-12-10T18:06:08.493Z"}, {"entity": "publication", "iuid": "7b2ef4c42a3d47fc89c04b015438c234", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b2ef4c42a3d47fc89c04b015438c234.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b2ef4c42a3d47fc89c04b015438c234"}}, "title": "Accessible data curation and analytics for international-scale citizen science datasets.", "authors": [{"family": "Murray", "given": "Benjamin", "initials": "B", "orcid": "0000-0002-2413-923X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebec738df0224bf4874fd6c08fd23fae.json"}}, {"family": "Kerfoot", "given": "Eric", "initials": "E"}, {"family": "Chen", "given": "Liyuan", "initials": "L"}, {"family": "Deng", "given": "Jie", "initials": "J"}, {"family": "Graham", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-4170-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f5f4e19812a46ed9e873732ec25e28d.json"}}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Molteni", "given": "Erika", "initials": "E", "orcid": "0000-0001-7773-8140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9aed1fbe444b48d4bfacb12050953c8e.json"}}, {"family": "Canas", "given": "Liane S", "initials": "LS", "orcid": "0000-0002-2553-1284", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c8d4abc0be246a1b77bf183be19efb6.json"}}, {"family": "Antonelli", "given": "Michela", "initials": "M"}, {"family": "Klaser", "given": "Kerstin", "initials": "K"}, {"family": "Visconti", "given": "Alessia", "initials": "A", "orcid": "0000-0003-4144-2019", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ce0429ccf674827aedbb8d05a53145c.json"}}, {"family": "Hammers", "given": "Alexander", "initials": "A", "orcid": "0000-0001-9530-4848", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aade93dbff2d4187a039a8e50027ed9c.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-7284-6767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeefbf47fd384d5390109fe1a903bd18.json"}}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Davies", "given": "Richard", "initials": "R", "orcid": "0000-0003-2050-3994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b82cc92615f462d9af0153a6fb94fde.json"}}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Modat", "given": "Marc", "initials": "M"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}], "type": "journal article", "published": "2021-11-22", "journal": {"title": "Sci Data", "issn": "2052-4463", "issn-l": null, "volume": "8", "issue": "1", "pages": "297"}, "abstract": "The Covid Symptom Study, a smartphone-based surveillance study on COVID-19 symptoms in the population, is an exemplar of big data citizen science. As of May 23rd, 2021, over 5 million participants have collectively logged over 360 million self-assessment reports since its introduction in March 2020. The success of the Covid Symptom Study creates significant technical challenges around effective data curation. The primary issue is scale. The size of the dataset means that it can no longer be readily processed using standard Python-based data analytics software such as Pandas on commodity hardware. Alternative technologies exist but carry a higher technical complexity and are less accessible to many researchers. We present ExeTera, a Python-based open source software package designed to provide Pandas-like data analytics on datasets that approach terabyte scales. We present its design and capabilities, and show how it is a critical component of a data curation pipeline that enables reproducible research across an international research group for the Covid Symptom Study.", "doi": "10.1038/s41597-021-01071-x", "pmid": "34811392", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41597-021-01071-x"}, {"db": "pmc", "key": "PMC8608807"}, {"db": "URL", "key": "https://github.com/KCL-BMEIS/ExeTera", "description": "https://github.com/KCL-BMEIS/ExeTera"}, {"db": "URL", "key": "https://github.com/KCL-BMEIS/ExeTera/wiki", "description": "https://github.com/KCL-BMEIS/ExeTera/wiki"}], "notes": [], "created": "2021-11-26T13:50:02.786Z", "modified": "2021-12-10T18:03:32.696Z"}, {"entity": "publication", "iuid": "15305e51a3c54f05ae698e9df0084837", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15305e51a3c54f05ae698e9df0084837.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15305e51a3c54f05ae698e9df0084837"}}, "title": "Defining the impact of SARS-COV-2 on delivery of CAR T-cell therapy in Europe: a retrospective survey from the CTIWP of the EBMT.", "authors": [{"family": "Ghorashian", "given": "Sara", "initials": "S", "orcid": "0000-0002-1555-2946", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fec721406a44d8983774c214511454d.json"}}, {"family": "Malard", "given": "Florent", "initials": "F"}, {"family": "Y\u00fcksel", "given": "Meltem Kurt", "initials": "MK"}, {"family": "Mauff", "given": "Katya", "initials": "K"}, {"family": "Hoogenboom", "given": "Jorinde D", "initials": "JD"}, {"family": "Urbano-Ispizua", "given": "Alvaro", "initials": "A"}, {"family": "Kuball", "given": "J\u00fcrgen", "initials": "J", "orcid": "0000-0002-3914-7806", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93b68b37f90949f681e03905510def84.json"}}, {"family": "de la Camara", "given": "Rafael", "initials": "R", "orcid": "0000-0002-8189-5779", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/868bc0284ac640a1bf215e7d7cc86da3.json"}}, {"family": "Ljungman", "given": "Per", "initials": "P", "orcid": "0000-0002-8281-3245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4546eb504184683ab712eee858ea9cb.json"}}, {"family": "Ruggeri", "given": "Annalisa", "initials": "A"}, {"family": "Chabannon", "given": "Christian", "initials": "C", "orcid": "0000-0002-3755-4889", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6383ab718ee423da23a515b971751bc.json"}}], "type": "letter", "published": "2021-11-20", "journal": {"title": "Bone Marrow Transplant", "issn": "1476-5365", "issn-l": "0268-3369"}, "abstract": null, "doi": "10.1038/s41409-021-01483-8", "pmid": "34802048", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41409-021-01483-8"}, {"db": "pmc", "key": "PMC8605455"}], "notes": [], "created": "2021-11-26T13:56:54.008Z", "modified": "2021-12-10T17:55:26.855Z"}, {"entity": "publication", "iuid": "21d56c12669e4c4fa3c217c0af208c34", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/21d56c12669e4c4fa3c217c0af208c34.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/21d56c12669e4c4fa3c217c0af208c34"}}, "title": "Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials.", "authors": [{"family": "Axfors", "given": "Cathrine", "initials": "C"}, {"family": "Janiaud", "given": "Perrine", "initials": "P"}, {"family": "Schmitt", "given": "Andreas M", "initials": "AM"}, {"family": "Van't Hooft", "given": "Janneke", "initials": "J"}, {"family": 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"initials": "Y"}, {"family": "Webb", "given": "Steve A", "initials": "SA"}, {"family": "Wiese", "given": "Lothar", "initials": "L"}, {"family": "Wik\u00e9n", "given": "Christian", "initials": "C"}, {"family": "Wood", "given": "Erica M", "initials": "EM"}, {"family": "Yusubalieva", "given": "Gaukhar M", "initials": "GM"}, {"family": "Zacharowski", "given": "Kai", "initials": "K"}, {"family": "Zarychanski", "given": "Ryan", "initials": "R"}, {"family": "Khanna", "given": "Nina", "initials": "N"}, {"family": "Moher", "given": "David", "initials": "D"}, {"family": "Goodman", "given": "Steven N", "initials": "SN"}, {"family": "Ioannidis", "given": "John P A", "initials": "JPA"}, {"family": "Hemkens", "given": "Lars G", "initials": "LG"}], "type": "journal article", "published": "2021-11-20", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "volume": "21", "issue": "1", "pages": "1170", "issn-l": null}, "abstract": "Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment and all-cause mortality in patients with COVID-19, using data from all available randomized clinical trials, including unpublished and ongoing trials (Open Science Framework, https://doi.org/10.17605/OSF.IO/GEHFX ).\n\nIn this collaborative systematic review and meta-analysis, clinical trial registries (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform), the Cochrane COVID-19 register, the LOVE database, and PubMed were searched until April 8, 2021. Investigators of trials registered by March 1, 2021, without published results were contacted via email. Eligible were ongoing, discontinued and completed randomized clinical trials that compared convalescent plasma with placebo or no treatment in COVID-19 patients, regardless of setting or treatment schedule. Aggregated mortality data were extracted from publications or provided by investigators of unpublished trials and combined using the Hartung-Knapp-Sidik-Jonkman random effects model. We investigated the contribution of unpublished trials to the overall evidence.\n\nA total of 16,477 patients were included in 33 trials (20 unpublished with 3190 patients, 13 published with 13,287 patients). 32 trials enrolled only hospitalized patients (including 3 with only intensive care unit patients). Risk of bias was low for 29/33 trials. Of 8495 patients who received convalescent plasma, 1997 died (23%), and of 7982 control patients, 1952 died (24%). The combined risk ratio for all-cause mortality was 0.97 (95% confidence interval: 0.92; 1.02) with between-study heterogeneity not beyond chance (I2 = 0%). The RECOVERY trial had 69.8% and the unpublished evidence 25.3% of the weight in the meta-analysis.\n\nConvalescent plasma treatment of patients with COVID-19 did not reduce all-cause mortality. These results provide strong evidence that convalescent plasma treatment for patients with COVID-19 should not be used outside of randomized trials. Evidence synthesis from collaborations among trial investigators can inform both evidence generation and evidence application in patient care.", "doi": "10.1186/s12879-021-06829-7", "pmid": "34800996", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12879-021-06829-7"}, {"db": "pmc", "key": "PMC8605464"}, {"db": "URL", "key": "Open Science Framework https://osf.io/gehfx/", "description": "https://osf.io/gehfx/"}], "notes": [], "created": "2021-11-26T13:57:19.972Z", "modified": "2021-11-26T13:58:22.778Z"}, {"entity": "publication", "iuid": "ba87bfd694b0454f8117a4874c4dd903", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ba87bfd694b0454f8117a4874c4dd903.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ba87bfd694b0454f8117a4874c4dd903"}}, "title": "Parturient with Covid-19 and need for intensive care: an observational study in the Nordic countries.", "authors": [{"family": "Karlsson", "given": "Ove", "initials": "O"}, {"family": "Hein", "given": "Anette", "initials": "A"}, {"family": "Eriksson", "given": "Susanne Ledin", "initials": "SL"}, {"family": "Pettersson", "given": "Karin", "initials": "K"}], "type": "letter", "published": "2021-11-19", "journal": {"title": "Am J Obstet Gynecol MFM", "issn": "2589-9333", "pages": "100532", "issn-l": null}, "abstract": null, "doi": "10.1016/j.ajogmf.2021.100532", "pmid": "34808399", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2589-9333(21)00228-7"}, {"db": "pmc", "key": "PMC8603919"}], "notes": [], "created": "2021-11-26T13:54:43.704Z", "modified": "2021-12-10T18:05:37.974Z"}, {"entity": "publication", "iuid": "2204d45084694f919be24fa50620fda0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2204d45084694f919be24fa50620fda0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2204d45084694f919be24fa50620fda0"}}, "title": "Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities.", "authors": [{"family": "Kruse", "given": "Thomas", "initials": "T"}, {"family": "Benz", "given": "Caroline", "initials": "C", "orcid": "0000-0002-5166-3598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13332514bfe7460db4a0f134718aa211.json"}}, {"family": "Garvanska", "given": "Dimitriya H", "initials": "DH"}, {"family": "Lindqvist", "given": "Richard", "initials": "R"}, {"family": "Mihalic", "given": "Filip", "initials": "F"}, {"family": "Coscia", "given": "Fabian", "initials": "F"}, {"family": "Inturi", "given": "Raviteja", "initials": "R", "orcid": "0000-0003-1344-3962", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6636c43ae584420fbe80f82393225824.json"}}, {"family": "Sayadi", "given": "Ahmed", "initials": "A"}, {"family": "Simonetti", "given": "Leandro", "initials": "L", "orcid": "0000-0003-1283-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9ef81e96c104878a6ccea620fc95400.json"}}, {"family": "Nilsson", "given": "Emma", "initials": "E"}, {"family": "Ali", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-8858-6776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0515e4fd072741b0a01456320bbf73de.json"}}, {"family": "Kliche", "given": "Johanna", "initials": "J"}, {"family": "Moliner Morro", "given": "Ainhoa", "initials": "A"}, {"family": "Mund", "given": "Andreas", "initials": "A", "orcid": "0000-0002-7843-5341", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e533a4bd6914e68be49773ccf0db693.json"}}, {"family": "Andersson", "given": "Eva", "initials": "E"}, {"family": "McInerney", "given": "Gerald", "initials": "G", "orcid": "0000-0003-2257-7241", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7770437d845444a8a07865bf5b62fab0.json"}}, {"family": "Mann", "given": "Matthias", "initials": "M"}, {"family": "Jemth", "given": "Per", "initials": "P", "orcid": "0000-0003-1516-7228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c5fe566cf5f44df9c98bb2b1d7078ba.json"}}, {"family": "Davey", "given": "Norman E", "initials": "NE"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK", "orcid": "0000-0001-6553-0940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9024ab251cf44bffbf3229ec909343af.json"}}, {"family": "Nilsson", "given": "Jakob", "initials": "J", "orcid": "0000-0003-4100-1125", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f2ecaef653e54c63b20d88574c03b8b2.json"}}, {"family": "Ivarsson", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-7081-3846", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b3cf0504a1b476f906c4b3e22b05d5a.json"}}], "type": "journal article", "published": "2021-11-19", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "6761"}, "abstract": "Viral proteins make extensive use of short peptide interaction motifs to hijack cellular host factors. However, most current large-scale methods do not identify this important class of protein-protein interactions. Uncovering peptide mediated interactions provides both a molecular understanding of viral interactions with their host and the foundation for developing novel antiviral reagents. Here we describe a viral peptide discovery approach covering 23 coronavirus strains that provides high resolution information on direct virus-host interactions. We identify 269 peptide-based interactions for 18 coronaviruses including a specific interaction between the human G3BP1/2 proteins and an \u03a6xFG peptide motif in the SARS-CoV-2 nucleocapsid (N) protein. This interaction supports viral replication and through its \u03a6xFG motif N rewires the G3BP1/2 interactome to disrupt stress granules. A peptide-based inhibitor disrupting the G3BP1/2-N interaction dampened SARS-CoV-2 infection showing that our results can be directly translated into novel specific antiviral reagents.", "doi": "10.1038/s41467-021-26498-z", "pmid": "34799561", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null, "Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC8605023"}, {"db": "pii", "key": "10.1038/s41467-021-26498-z"}], "notes": [], "created": "2021-11-26T14:03:59.548Z", "modified": "2023-06-19T15:06:00.564Z"}, {"entity": "publication", "iuid": "57ffc67fec3d47b49ba7cb301f827abc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/57ffc67fec3d47b49ba7cb301f827abc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/57ffc67fec3d47b49ba7cb301f827abc"}}, "title": "High sleep fragmentation parallels poor subjective sleep quality during the third wave of the Covid-19 pandemic: An actigraphic study.", "authors": [{"family": "Conte", "given": "Francesca", "initials": "F", "orcid": "0000-0002-5429-5831", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25298eaae41b49a58d9103796937f69e.json"}}, {"family": "De Rosa", "given": "Oreste", "initials": "O"}, {"family": "Rescott", "given": "Marissa Lynn", "initials": "ML"}, {"family": "Arabia", "given": "Teresa Pia", "initials": "TP"}, {"family": "D'Onofrio", "given": "Paolo", "initials": "P"}, {"family": "Lustro", "given": "Alessio", "initials": "A"}, {"family": "Malloggi", "given": "Serena", "initials": "S", "orcid": "0000-0003-1813-8916", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb2487e0d35c41f8b75fba2f7a6441d2.json"}}, {"family": "Molinaro", "given": "Danila", "initials": "D"}, {"family": "Spagnoli", "given": "Paola", "initials": "P"}, {"family": "Giganti", "given": "Fiorenza", "initials": "F", "orcid": "0000-0002-9362-5258", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/99e3ab3bd59b425ab8b21b806500774e.json"}}, {"family": "Barbato", "given": "Giuseppe", "initials": "G", "orcid": "0000-0001-6523-5327", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47264cf640f74008afde9622672a452d.json"}}, {"family": "Ficca", "given": "Gianluca", "initials": "G", "orcid": "0000-0001-9519-4351", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c00e9acb5674411ac84ab79c36b8b22.json"}}], "type": "journal article", "published": "2021-11-19", "journal": {"title": "J Sleep Res", "issn": "1365-2869", "pages": "e13519", "issn-l": "0962-1105"}, "abstract": "Studies on sleep during the Covid-19 pandemic have mostly been conducted during the first wave of contagion (spring 2020). To follow up on two Italian studies addressing subjective sleep features during the second wave (autumn 2020), here we assess sleep during the third wave (spring 2021) in a sample of healthy adults from Campania (Southern Italy). Actigraphic data (on 2 nights) and the Pittsburgh Sleep Quality Index were collected from 82 participants (40 F, mean age: 32.5 \u00b1 11.5 years) from 11 March to 18 April 2021, when Campania was classified as a \"red zone\", i.e. it was subjected to strict restrictions, only slightly looser than those characterizing the first national lockdown (spring 2020). Although objective sleep duration and architecture appeared in the normal range, the presence of disrupted sleep was indexed by a relevant degree of sleep fragmentation (number of awakenings \u2265 1 min: 12.7 \u00b1 6.12; number of awakenings \u2265 5 min: 3.04 \u00b1 1.52), paralleled by poor subjective sleep quality (Pittsburgh Sleep Quality Index global score: 5.77 \u00b1 2.58). These data suggest that the relevant subjective sleep impairments reported during the first wave could have relied on subtle sleep disruptions that were undetected by the few objective sleep studies from the same period. Taken together with sleep data on previous phases of the pandemic, our findings show that the detrimental effects on sleep determined by the initial pandemic outbreak have not abated across the subsequent waves of contagion, and highlight the need for interventions addressing sleep health in global emergencies.", "doi": "10.1111/jsr.13519", "pmid": "34797004", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T14:05:35.775Z", "modified": "2021-11-26T14:05:35.965Z"}, {"entity": "publication", "iuid": "42a5b1f5ed414ca89ebfa2f8135b2fdf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/42a5b1f5ed414ca89ebfa2f8135b2fdf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/42a5b1f5ed414ca89ebfa2f8135b2fdf"}}, "title": "Fear of COVID-19 and Trust in the Healthcare System Mediates the Association between Individual's Risk Perception and Preventive COVID-19 Behaviours among Iranians.", "authors": [{"family": "Alijanzadeh", "given": "Mehran", "initials": "M"}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK", "orcid": "0000-0003-0530-8138", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d442447b551649d8a5372c6bf0075c91.json"}}, {"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Mahmoudi", "given": "Narges", "initials": "N"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Liu", "given": "Hsien-Kuan", "initials": "HK", "orcid": "0000-0003-0176-1381", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee8322e92e0e4d9cb5739b6fa1ac9d7f.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-11-19", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "22", "issn-l": null}, "abstract": "Problems caused by the novel coronavirus disease-2019 (COVID-19) and its mutations have brought challenges in pandemic control for all countries worldwide. The present study examines the mediating roles of fear of COVID-19 and trust in the healthcare system in the association between individual's risk perception and performing preventive COVID-19 behaviours among Iranians. A cross-sectional study design was used to collect data from 3652 residents of Qazvin province in Iran from 3 February to 15 April 2021 using a multistage stratified cluster sampling method. Participants responded to an online questionnaire concerning their fear of COVID-19, risk perception, trust in the healthcare system, and preventive COVID-19 behaviours. Small to medium positive interrelationships were observed between the variables of the study. Fear of COVID-19, trust in the healthcare system or both (fear of COVID-19 and trust in the healthcare system) mediated the association between an individual's risk perception and performing preventive COVID-19 behaviours. The study demonstrated there are at least four ways through which an individual's risk perception can influence preventive COVID-19 behaviours. Therefore, clinicians, health communicators, and researchers may capitalize on these findings to enhance preventive COVID-19 behaviours to help mitigate the spread of COVID-19 infection.", "doi": "10.3390/ijerph182212146", "pmid": "34831900", "labels": {"Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182212146"}, {"db": "pmc", "key": "PMC8621944"}], "notes": [], "created": "2021-12-18T18:16:01.936Z", "modified": "2021-12-18T18:16:02.033Z"}, {"entity": "publication", "iuid": "f645e0019835455a984c862319a6db39", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f645e0019835455a984c862319a6db39.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f645e0019835455a984c862319a6db39"}}, "title": "Clinical and hospitalisation predictors of COVID-19 in the first month of the pandemic, Portugal.", "authors": [{"family": "Perez Duque", "given": "Mariana", "initials": "M", "orcid": "0000-0001-9999-8402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6f20ad39f5c74255b07b64d6dc93f17c.json"}}, {"family": "Saad", "given": "Neil J", "initials": "NJ"}, {"family": "Lucaccioni", "given": "H\u00e9lo\u00efse", "initials": "H"}, {"family": "Costa", "given": "Cristina", "initials": "C"}, {"family": "McMahon", "given": "Geroid", "initials": "G"}, {"family": "Machado", "given": "Firmino", "initials": "F"}, {"family": "Balasegaram", "given": "Sooria", "initials": "S"}, {"family": "S\u00e1 Machado", "given": "Rita", "initials": "R"}], "type": "journal article", "published": "2021-11-19", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "11", "pages": "e0260249", "issn-l": "1932-6203"}, "abstract": "COVID-19 mainly presents as a respiratory disease with flu-like symptoms, however, recent findings suggest that non-respiratory symptoms can occur early in the infection and cluster together in different groups in different regions. We collected surveillance data among COVID-19 suspected cases tested in mainland Portugal during the first wave of the pandemic, March-April 2020. A multivariable logistic-regression analysis was performed to ascertain the effects of age, sex, prior medical condition and symptoms on the likelihood of testing positive and hospitalisation. Of 25,926 COVID-19 suspected cases included in this study, 5,298 (20%) tested positive. Symptoms were grouped into ten clusters, of which two main ones: one with cough and fever and another with the remainder. There was a higher odds of a positive test with increasing age, myalgia and headache. The odds of being hospitalised increased with age, presence of fever, dyspnoea, or having a prior medical condition although these results varied by region. Presence of cough and other respiratory symptoms did not predict COVID-19 compared to non-COVID respiratory disease patients in any region. Dyspnoea was a strong determinant of hospitalisation, as well as fever and the presence of a prior medical condition, whereas these results varied by region.", "doi": "10.1371/journal.pone.0260249", "pmid": "34797879", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-13990"}, {"db": "pmc", "key": "PMC8604361"}], "notes": [], "created": "2021-11-26T14:05:16.418Z", "modified": "2021-11-26T14:05:16.473Z"}, {"entity": "publication", "iuid": "75fa1f2465c24fa18ebf10faee384bc8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/75fa1f2465c24fa18ebf10faee384bc8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/75fa1f2465c24fa18ebf10faee384bc8"}}, "title": "COVID-19 Testing in Sweden During 2020-Split Responsibilities and Multi-Level Challenges.", "authors": [{"family": "Fredriksson", "given": "Mio", "initials": "M"}, {"family": "Hallberg", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-11-19", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "754861", "issn-l": "2296-2565"}, "abstract": "Sweden's use of soft response measures early in the COVID-19 pandemic received a good deal of international attention. Within Sweden, one of the most debated aspects of the pandemic response has been COVID-19 testing and the time it took to increase testing capacity. In this article, the development of and the debate surrounding COVID-19 testing in Sweden during 2020 is described in detail, with a particular focus on the coordination between national and regional actors in the decentralised healthcare system. A qualitative case study was carried out based on qualitative document analysis with a chronological presentation. To understand COVID-19 testing in Sweden, two aspects of its public administration model emerged as particularly important: (i) the large and independent government agencies and (ii) self-governing regions and municipalities. In addition, the responsibility principle in Swedish crisis management was crucial. Overall, the results show that mass testing was a new area for coordination and involved a number of national and regional actors with partly different views on their respective roles, responsibilities and interpretations of the laws and regulations. The description shows the ambiguities in the purpose of testing and the shortcomings in communication and cooperation during the first half of 2020, but after that an increasing consistency among the crucial actors. During the first half of 2020, testing capacity in Sweden was limited and reserved to protect the most vulnerable in society. Because mass testing for viruses is not normally carried out by the 21 self-governing regions responsible for healthcare and communicable disease prevention, and the Public Health Agency of Sweden stated that there was no medical reason to test members of the public falling ill with COVID-like symptoms, the responsibility for mass testing fell through the cracks during the first few months of the pandemic. This article thus illustrates problems associated with multi-level governance in healthcare during a crisis and illustrates the discrepancy between the health service's focus on the individual and the public health-oriented work carried out within communicable disease control.", "doi": "10.3389/fpubh.2021.754861", "pmid": "34869171", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC8639858"}], "notes": [], "created": "2021-12-12T07:09:35.537Z", "modified": "2023-07-13T11:28:19.389Z"}, {"entity": "publication", "iuid": "0c76fbcbdeaf4122ba8d9d2e761978e6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c76fbcbdeaf4122ba8d9d2e761978e6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c76fbcbdeaf4122ba8d9d2e761978e6"}}, "title": "'Who will do it if I don't?' Nurse anaesthetists' experiences of working in the intensive care unit during the COVID-19 pandemic.", "authors": [{"family": "Hallgren", "given": "Jenny", "initials": "J"}, {"family": "Larsson", "given": "Margaretha", "initials": "M"}, {"family": "Kjell\u00e9n", "given": "Malin", "initials": "M"}, {"family": "Lagerroth", "given": "David", "initials": "D"}, {"family": "B\u00e4ckstr\u00f6m", "given": "Caroline", "initials": "C"}], "type": "journal article", "published": "2021-11-19", "journal": {"title": "Aust Crit Care", "issn": "1036-7314", "issn-l": null}, "abstract": "During the COVID-19 pandemic, the workload on the intensive care unit (ICU) increased nationally in Sweden as well as globally. Certified registered nurse anaesthetists (CRNAs) in Sweden were transferred at short notice to work with seriously ill patients with COVID-19 in the ICU, which is not part of the CRNAs' specialist area. However, limited research has shed light on healthcare professionals' experiences of the pandemic.\n\nThis study illuminates CRNAs' experiences of working in the ICU during the COVID-19 pandemic.\n\nThis study used a qualitative method with an inductive approach to interview nurse anaesthetists who worked in the ICU during the COVID-19 pandemic.\n\nThe participants experienced ambivalent feelings towards their work in the ICU. They also lacked information, which created feelings of uncertainty and resulted in expectations that did not correspond to the reality. They described that owing to an inadequate introduction, they could only provide \"sufficient\" care, which in many cases caused ethical stress. Not being able to get to know their new colleagues well enough to create effective cooperation created frustration. Even though the participants experienced the work in the ICU as demanding and challenging, overall, they enjoyed their time in the ICU and were treated well by their colleagues.\n\nAlthough CRNAs cannot replace intensive care nurses, they are a useful resource in the ICU in the care of patients with COVID-19. Healthcare workers who are allocated from their ordinary units to the ICU need adequate information and support from their work managers to be able to provide the best possible care and to stay healthy themselves.", "doi": "10.1016/j.aucc.2021.11.003", "pmid": "34955333", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1036-7314(21)00171-5"}, {"db": "pmc", "key": "PMC8602969"}], "notes": [], "created": "2022-01-04T15:25:03.308Z", "modified": "2022-01-04T15:25:03.321Z"}, {"entity": "publication", "iuid": "eb87609ca02340e78b47e4023949bbcd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb87609ca02340e78b47e4023949bbcd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb87609ca02340e78b47e4023949bbcd"}}, "title": "The extent of neuroradiological findings in COVID-19 shows correlation with blood biomarkers, Glasgow coma scale score and days in intensive care.", "authors": [{"family": "F\u00e4llmar", "given": "David", "initials": "D"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ"}, {"family": "Jackmann", "given": "Sven", "initials": "S"}, {"family": "Pavel", "given": "Radu", "initials": "R"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Westman", "given": "Gabriel", "initials": "G"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Virhammar", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2021-11-18", "journal": {"title": "J Neuroradiol", "issn": "0150-9861", "issn-l": null}, "abstract": "A wide range of neuroradiological findings has been reported in patients with coronavirus disease 2019 (COVID-19), ranging from subcortical white matter changes to infarcts, haemorrhages and focal contrast media enhancement. These have been descriptively but inconsistently reported and correlations with clinical findings and biomarkers have been difficult to extract from the literature. The purpose of this study was to quantify the extents of neuroradiological findings in a cohort of patients with COVID-19 and neurological symptoms, and to investigate correlations with clinical findings, duration of intensive care and biomarkers in blood.\n\nPatients with positive SARS-CoV-2 and at least one new-onset neurological symptom were included from April until July 2020. Nineteen patients were examined regarding clinical symptoms, biomarkers in blood and MRI of the brain. In order to quantify the MRI findings, a semi-quantitative neuroradiological severity scale was constructed a priori, and applied to the MR images by two specialists in neuroradiology.\n\nThe score from the severity scale correlated significantly with blood biomarkers of CNS injury (glial fibrillary acidic protein, total-tau, ubiquitin carboxyl-terminal hydrolase L1) and inflammation (C-reactive protein), Glasgow Coma Scale score, and the number of days spent in intensive care. The underlying radiological assessments had inter-rater agreements of 90.5%/86% (for assessments with 2/3 alternatives). Total intraclass correlation was 0.80. Previously reported neuroradiological findings in COVID-19 have been diverse and heterogenous. In this study, the extent of findings in MRI examination of the brain, quantified using a structured report, shows correlation with relevant biomarkers.", "doi": "10.1016/j.neurad.2021.11.003", "pmid": "34800562", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0150-9861(21)00167-X"}, {"db": "pmc", "key": "PMC8599173"}], "notes": [], "created": "2021-11-26T14:02:06.243Z", "modified": "2021-12-10T17:54:55.138Z"}, {"entity": "publication", "iuid": "61d8c768c9ee42fb8ec88ce2408194e9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61d8c768c9ee42fb8ec88ce2408194e9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61d8c768c9ee42fb8ec88ce2408194e9"}}, "title": "Red blood cell blood group A antigen level affects the ability of heparin and PfEMP1 antibodies to disrupt Plasmodium falciparum rosettes.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P", "orcid": "0000-0003-3153-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd6af5accfc84ff9a81983a5ab6683aa.json"}}, {"family": "Sirel", "given": "Madle", "initials": "M"}, {"family": "Moll", "given": "Kirsten", "initials": "K"}, {"family": "Kiwuwa", "given": "Mpungu Steven", "initials": "MS"}, {"family": "H\u00f6glund", "given": "Petter", "initials": "P"}, {"family": "Ribacke", "given": "Ulf", "initials": "U"}, {"family": "Wahlgren", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2021-11-18", "journal": {"title": "Malar J", "issn": "1475-2875", "volume": "20", "issue": "1", "pages": "441", "issn-l": null}, "abstract": "The histo-blood group ABO system has been associated with adverse outcomes in COVID-19, thromboembolic diseases and Plasmodium falciparum malaria. An integral part of the severe malaria pathogenesis is rosetting, the adherence of parasite infected red blood cells (RBCs) to uninfected RBCs. Rosetting is influenced by the host's ABO blood group (Bg) and rosettes formed in BgA have previously been shown to be more resilient to disruption by heparin and shield the parasite derived surface antigens from antibodies. However, data on rosetting in weak BgA subgroups is scarce and based on investigations of relatively few donors.\n\nAn improved high-throughput flow cytometric assay was employed to investigate rosetting characteristics in an extensive panel of RBC donor samples of all four major ABO Bgs, as well as low BgA expressing samples.\n\nAll non-O Bgs shield the parasite surface antigens from strain-specific antibodies towards P. falciparum erythrocyte membrane protein 1 (PfEMP1). A positive correlation between A-antigen levels on RBCs and rosette tightness was observed, protecting the rosettes from heparin- and antibody-mediated disruption.\n\nThese results provide new insights into how the ABO Bg system affects the disease outcome and cautions against interpreting the results from the heterogeneous BgA phenotype as a single group in epidemiological and experimental studies.", "doi": "10.1186/s12936-021-03975-w", "pmid": "34794445", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12936-021-03975-w"}, {"db": "pmc", "key": "PMC8600353"}], "notes": [], "created": "2021-11-26T14:10:07.743Z", "modified": "2021-11-26T14:10:07.797Z"}, {"entity": "publication", "iuid": "701bbb9615b6499f804cebf6ab23736f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/701bbb9615b6499f804cebf6ab23736f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/701bbb9615b6499f804cebf6ab23736f"}}, "title": "Are sex disparities in COVID-19 a predictable outcome of failing men's health provision?", "authors": [{"family": "Tharakan", "given": "Tharu", "initials": "T"}, {"family": "Khoo", "given": "Christopher C", "initials": "CC", "orcid": "0000-0002-1706-2457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4577a71a676e449caa7c8f224b4da83f.json"}}, {"family": "Giwercman", "given": "Aleksander", "initials": "A"}, {"family": "Jayasena", "given": "Channa N", "initials": "CN", "orcid": "0000-0002-2578-8223", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b94255faecdd403a951cd4d854c1fb7d.json"}}, {"family": "Sofikitis", "given": "Nikolaos", "initials": "N", "orcid": "0000-0003-1528-4029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/878fcbbf78bf4f98bc7622484e44415d.json"}}, {"family": "Salonia", "given": "Andrea", "initials": "A", "orcid": "0000-0002-0595-7165", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/940b454070ba44e8ad349d3c8f6c06c3.json"}}, {"family": "Minhas", "given": "Suks", "initials": "S"}], "type": "journal article", "published": "2021-11-18", "journal": {"title": "Nat Rev Urol", "issn": "1759-4820", "issn-l": null}, "abstract": "The COVID-19 pandemic, caused by the SARS-CoV-2 coronavirus, has taken a catastrophic toll on society, health-care systems and the economy. Notably, COVID-19 has been shown to be associated with a higher mortality rate in men than in women. This disparity is likely to be a consequence of a failure to invest in men's health, as it has also been established that men have a lower life expectancy and poorer outcomes from non-communicable diseases than women. A variety of biological, social and economic factors have contributed to the sex disparities in mortality from COVID-19. A streamlined men's health programme - with the urologist as the gatekeeper of men's health - is needed to help prevent future tragedies of this nature.", "doi": "10.1038/s41585-021-00535-4", "pmid": "34795426", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41585-021-00535-4"}, {"db": "pmc", "key": "PMC8600906"}], "notes": [], "created": "2021-11-26T14:08:51.860Z", "modified": "2021-11-26T14:08:52.023Z"}, {"entity": "publication", "iuid": "d60de72901f74a45895fc2c45e98c87b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d60de72901f74a45895fc2c45e98c87b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d60de72901f74a45895fc2c45e98c87b"}}, "title": "Analyzing the Stressors for Frontline Soldiers Fighting Against Coronavirus Disease 2019 Pandemic.", "authors": [{"family": "Shaukat", "given": "Muhammad Zeeshan", "initials": "MZ"}, {"family": "Scholz", "given": "Miklas", "initials": "M"}, {"family": "Qazi", "given": "Tehmina Fiaz", "initials": "TF"}, {"family": "Niazi", "given": "Abdul Aziz Khan", "initials": "AAK"}, {"family": "Basit", "given": "Abdul", "initials": "A"}, {"family": "Mahmood", "given": "Asif", "initials": "A"}], "type": "journal article", "published": "2021-11-18", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "751882", "issn-l": "1664-1078"}, "abstract": "This study aimed to analyze stressors to which medical staff is vulnerable due to the coronavirus disease 2019 (COVID-19) pandemic. It also imposes a hierarchy on complex relations among stressors for excavating underlying structure and builds a model of interrelationships contrasting reality. The design of this study comprises a literature survey, data collection from primary sources, and analysis. Stressors have been explored from within current published/unpublished literature and validated by experts through approval vote. Data were collected from the focus group (panel of experts), and interpretive structural modeling (ISM) was used as the research methodology. Findings of ISM are avowed through \"cross-impact matrix multiplication applied to classification\" (MICMAC) analysis. As a result of the literature survey, a list of stressors was generated, and a total of 19 stressors qualified as representative of the phenomenon. The results of ISM show that two stressors (i.e., \"unavailability of proper personal protective equipment (PPE)\" and \"lack of proper communication\") emerged as the most critical stressors since they occupy the bottom of the model, whereas, four stressors (i.e., \"anxious about isolation/quarantine,\" \"subject to violent crimes,\" \"feeling frustrated and powerless,\" and \"exhausting shifts/hours without clear end\") are relatively less critical since they occupy the top of the model. The rest of the stressors occupy the middle of the model and therefore, have moderate-severe effects on frontline soldiers. The results of MICMAC show that the stressor \"subject to violent crimes\" is classified in the dependent cluster and the remaining fall in the linkage cluster but no stressor falls in independent and autonomous. Overall results indicate that all stressors are relevant to the phenomenon under this study, but they are currently not settled. This study is invaluable for policymakers, frontline soldiers, researchers, the international community, and society since it provides a lot of new information that is helpful in refining strategies and combating influential stressors.", "doi": "10.3389/fpsyg.2021.751882", "pmid": "34867641", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8636429"}], "notes": [], "created": "2021-12-12T07:07:18.693Z", "modified": "2021-12-12T07:07:36.228Z"}, {"entity": "publication", "iuid": "18e86ad4da7e436aacdfe11da55bc5f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18e86ad4da7e436aacdfe11da55bc5f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18e86ad4da7e436aacdfe11da55bc5f1"}}, "title": "Obstructive sleep apnea is an independent risk factor for severe COVID-19: a population-based study.", "authors": [{"family": "R\u00f6gnvaldsson", "given": "Kristj\u00e1n Godsk", "initials": "KG"}, {"family": "Ey\u00fe\u00f3rsson", "given": "El\u00edas S\u00e6bj\u00f6rn", "initials": "ES"}, {"family": "Emilsson", "given": "\u00d6ssur Ingi", "initials": "\u00d6I"}, {"family": "Eysteinsd\u00f3ttir", "given": "Bj\u00f6rg", "initials": "B"}, {"family": "P\u00e1lsson", "given": "Run\u00f3lfur", "initials": "R"}, {"family": "Gottfre\u00f0sson", "given": "Magn\u00fas", "initials": "M"}, {"family": "Gu\u00f0mundsson", "given": "Gunnar", "initials": "G"}, {"family": "Steingr\u00edmsson", "given": "Vilhj\u00e1lmur", "initials": "V"}], "type": "journal article", "published": "2021-11-17", "journal": {"title": "Sleep", "issn": "1550-9109", "issn-l": null}, "abstract": "Obstructive sleep apnea (OSA) has been proposed as a risk factor for severe COVID-19. Confounding is an important consideration as OSA is associated with several known risk factors for severe COVID-19. Our aim was to assess the association of OSA with hospitalization due to COVID-19 using a population-based cohort with detailed information on OSA and comorbidities.\n\nIncluded were all community-dwelling Icelandic citizens 18 years of age and older diagnosed with SARS-CoV-2 infection in 2020. Data on demographics, comorbidities, and outcomes of COVID-19 was obtained from centralized national registries. Diagnosis of OSA was retrieved from the centralized Sleep Department Registry at Landspitali-The National University Hospital. Severe COVID-19 was defined as the composite outcome of hospitalization and death. The associations between OSA and the outcome were expressed as odds ratios (OR) with 95% confidence intervals (95% CI), calculated using logistic regression models and inverse probability weighting.\n\nA total of 4,756 individuals diagnosed with SARS-CoV-2 infection in Iceland were included in the study (1.3% of the Icelandic population), of whom 185 had a diagnosis of OSA. In total, 238 were hospitalized or died, 38 of whom had OSA. Adjusted for age, sex, and BMI, OSA was associated with poor outcome (OR 2.2, 95% CI 1.4 -3.5). This association was slightly attenuated (OR 2.0, 95% CI 2.0, 1.2-3.2) when adjusted for demographic characteristics and various comorbidities.\n\nOSA was associated with twofold increase in risk of severe COVID-19, and the association was not explained by obesity or other comorbidities.", "doi": "10.1093/sleep/zsab272", "pmid": "34791469", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6430441"}], "notes": [], "created": "2021-11-26T14:10:27.773Z", "modified": "2021-11-26T14:10:27.786Z"}, {"entity": "publication", "iuid": "2db2e9c0e8964a27b948c7c2d484f5bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2db2e9c0e8964a27b948c7c2d484f5bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2db2e9c0e8964a27b948c7c2d484f5bf"}}, "title": "Impact of the Double Mutants on Spike Protein of SARS-CoV-2 B.1.617 Lineage on the Human ACE2 Receptor Binding: A Structural Insight.", "authors": [{"family": "Khan", "given": "Mohd Imran", "initials": "MI"}, {"family": "Baig", "given": "Mohammad Hassan", "initials": "MH", "orcid": "0000-0001-8227-4838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1fe7992c2c94f768b7b8d781c99c618.json"}}, {"family": "Mondal", "given": "Tanmoy", "initials": "T"}, {"family": "Alorabi", "given": "Mohammed", "initials": "M", "orcid": "0000-0002-4326-6066", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab180e94a4ae4dcf99c5f8ae79697e44.json"}}, {"family": "Sharma", "given": "Tanuj", "initials": "T"}, {"family": "Dong", "given": "Jae-June", "initials": "JJ", "orcid": "0000-0002-2420-2155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0de75e6c65df43d9a886bf95063d625a.json"}}, {"family": "Cho", "given": "Jae Yong", "initials": "JY"}], "type": "journal article", "published": "2021-11-17", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "11", "issn-l": "1999-4915"}, "abstract": "The recent emergence of novel SARS-CoV-2 variants has threatened the efforts to contain the COVID-19 pandemic. The emergence of these \"variants of concern\" has increased immune escape and has supplanted the ancestral strains. The novel variants harbored by the B.1.617 lineage (kappa and delta) carry mutations within the receptor-binding domain of spike (S) protein (L452R + E484Q and L452R + T478K), the region binding to the host receptor. The double mutations carried by these novel variants are primarily responsible for an upsurge number of COVID-19 cases in India. In this study, we thoroughly investigated the impact of these double mutations on the binding capability to the human host receptor. We performed several structural analyses and found that the studied double mutations increase the binding affinity of the spike protein to the human host receptor (ACE2). Furthermore, our study showed that these double mutants might be a dominant contributor enhancing the receptor-binding affinity of SARS-CoV-2 and consequently making it more stable. We also investigated the impact of these mutations on the binding affinity of two monoclonal antibodies (Abs) (2-15 and LY-CoV555) and found that the presence of the double mutations also hinders its binding with the studied Abs. The principal component analysis, free energy landscape, intermolecular interaction, and other investigations provided a deeper structural insight to better understand the molecular mechanism responsible for increased viral transmissibility of these variants.", "doi": "10.3390/v13112295", "pmid": "34835101", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "v13112295"}, {"db": "pmc", "key": "PMC8625741"}], "notes": [], "created": "2021-12-18T18:14:46.920Z", "modified": "2021-12-18T18:14:47.044Z"}, {"entity": "publication", "iuid": "6f4adb0b60cf45539307221b47720cde", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f4adb0b60cf45539307221b47720cde.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f4adb0b60cf45539307221b47720cde"}}, "title": "Impact of COVID-19 on global burn care.", "authors": [{"family": "Laura", "given": "Pompermaier", "initials": "P"}, {"family": "Jos\u00e9", "given": "Adorno", "initials": "A"}, {"family": "Nikki", "given": "Allorto", "initials": "A"}, {"family": "Khaled", "given": "Altarrah", "initials": "A"}, {"family": "Barret", "given": "Juan P", "initials": "JP"}, {"family": "Jeffery", "given": "Carter", "initials": "C"}, {"family": "Shobha", "given": "Chamania", "initials": "C"}, {"family": "Jack", "given": "Chong Si", "initials": "CS"}, {"family": "Scott", "given": "Corlew", "initials": "C"}, {"family": "Nadia", "given": "Depetris", "initials": "D"}, {"family": "Moustafa", "given": "Elmasry", "initials": "E"}, {"family": "Liao", "given": "Junlin", "initials": "J"}, {"family": "Josef", "given": "Haik", "initials": "H"}, {"family": "Briana", "given": "Horwath", "initials": "H"}, {"family": "Sunil", "given": "Keswani", "initials": "K"}, {"family": "Tetsuro", "given": "Kiyozumi", "initials": "K"}, {"family": "Jorge", "given": "Leon-Villapalos", "initials": "LV"}, {"family": "Gaoxing", "given": "Luo", "initials": "L"}, {"family": "Hajime", "given": "Matsumura", "initials": "M"}, {"family": "Ariel", "given": "Miranda-Altamirano", "initials": "MA"}, {"family": "Naiem", "given": "Moiemen", "initials": "M"}, {"family": "Kiran", "given": "Nakarmi", "initials": "N"}, {"family": "Nawar", "given": "Ahmed", "initials": "A"}, {"family": "Faustin", "given": "Ntirenganya", "initials": "N"}, {"family": "Anthony", "given": "Olekwu", "initials": "O"}, {"family": "Tom", "given": "Potokar", "initials": "P"}, {"family": "Liang", "given": "Qiao", "initials": "Q"}, {"family": "Man", "given": "Rai Shankar", "initials": "RS"}, {"family": "Ingrid", "given": "Steinvall", "initials": "S"}, {"family": "Ahmed", "given": "Tanveer", "initials": "T"}, {"family": "Molina", "given": "Vana Luiz Philipe", "initials": "VLP"}, {"family": "Shelley", "given": "Wall", "initials": "W"}, {"family": "Mark", "given": "Fisher", "initials": "F"}], "type": "journal article", "published": "2021-11-17", "journal": {"title": "Burns", "issn": "1879-1409", "issn-l": null}, "abstract": "Worldwide, different strategies have been chosen to face the COVID-19-patient surge, often affecting access to health care for other patients. This observational study aimed to investigate whether the standard of burn care changed globally during the pandemic, and whether country\u00b4s income, geographical location, COVID-19-transmission pattern, and levels of specialization of the burn units affected reallocation of resources and access to burn care.\n\nThe Burn Care Survey is a questionnaire developed to collect information on the capacity to provide burn care by burn units around the world, before and during the pandemic. The survey was distributed between September and October 2020. McNemar`s test analyzed differences between services provided before and during the pandemic, \u03c72 or Fisher's exact test differences between groups. Multivariable logistic regression analyzed the independent effect of different factors on keeping the burn units open during the pandemic.\n\nThe survey was completed by 234 burn units in 43 countries. During the pandemic, presence of burn surgeons did not change (p = 0.06), while that of anesthetists and dedicated nursing staff was reduced (<0.01), and so did the capacity to manage patients in all age groups (p = 0.04). Use of telemedicine was implemented (p < 0.01), collaboration between burn centers was not. Burn units in LMICs and LICs were more likely to be closed, after adjustment for other factors.\n\nDuring the pandemic, most burn units were open, although availability of standard resources diminished worldwide. The use of telemedicine increased, suggesting the implementation of new strategies to manage burns. Low income was independently associated with reduced access to burn care.", "doi": "10.1016/j.burns.2021.11.010", "pmid": "34903416", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0305-4179(21)00312-0"}, {"db": "pmc", "key": "PMC8664090"}], "notes": [], "created": "2021-12-18T17:59:08.739Z", "modified": "2021-12-18T17:59:08.775Z"}, {"entity": "publication", "iuid": "9bd7f6ad9b65462e99a211e5e7ebbfbb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9bd7f6ad9b65462e99a211e5e7ebbfbb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9bd7f6ad9b65462e99a211e5e7ebbfbb"}}, "title": "Duration of SARS-CoV-2 viremia and its correlation to mortality and inflammatory parameters in patients hospitalized for COVID-19: a cohort study.", "authors": [{"family": "Hagman", "given": "Karl", "initials": "K"}, {"family": "Hedenstierna", "given": "Magnus", "initials": "M"}, {"family": "Rudling", "given": "Johan", "initials": "J"}, {"family": "Gille-Johnson", "given": "Patrik", "initials": "P"}, {"family": "Hammas", "given": "Berit", "initials": "B"}, {"family": "Grabbe", "given": "Malin", "initials": "M"}, {"family": "Jakobsson", "given": "Jan", "initials": "J"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Ursing", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2021-11-17", "journal": {"title": "Diagn Microbiol Infect Dis", "issn": "1879-0070", "volume": "102", "issue": "3", "pages": "115595", "issn-l": null}, "abstract": "SARS-CoV-2 viremia at admission is associated with high risk for mortality. However, longitudinal data on viremia duration are limited. Viremic patients hospitalized for COVID-19 were included in a cohort. Time to serum viral clearance and the effect of viremia duration on the odds of mortality were calculated. One hundred and twenty-one viremic patients were included. Median age was 62 (IQR 52-71) years and 68% were males. The total in-hospital mortality of the cohort was 33%. Median time from admission to serum viral clearance was 7 (95% CI 6-8) days. Duration of viremia showed a relative risk ratio of 1.40 (95% CI 1.02-1.92) for the odds of mortality in an adjusted multinomial logistic regression. Serum viral clearance coincided with defervescence and decreasing C-reactive protein. Median time to serum viral clearance was 7 days after admission. The odds of mortality increased with 40% for each additional day of viremia.", "doi": "10.1016/j.diagmicrobio.2021.115595", "pmid": "34896666", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0732-8893(21)00286-8"}, {"db": "pmc", "key": "PMC8595972"}], "notes": [], "created": "2021-12-18T18:00:53.948Z", "modified": "2021-12-18T18:00:53.984Z"}, {"entity": "publication", "iuid": "e4bfeb90baee400ea2e8bdf13019a27d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e4bfeb90baee400ea2e8bdf13019a27d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e4bfeb90baee400ea2e8bdf13019a27d"}}, "title": "Critical care nurses' experiences of working during the first phase of the COVID-19 pandemic - Applying the Person-centred Practice Framework.", "authors": [{"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Nordin", "given": "Anna", "initials": "A"}, {"family": "Engstr\u00f6m", "given": "\u00c5sa", "initials": "\u00c5"}], "type": "journal article", "published": "2021-11-17", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "pages": "103179", "issn-l": null}, "abstract": "The aim of the study was to deductively study person-centred care, based on critical care nurses' experiences during the first phase of the CoViD-19 pandemic.\n\nThe study used a qualitative design.\n\nData collection was conducted as individual interviews and was analysed with qualitative content analysis with a deductive approach.\n\nSix critical care nurses working in a special CoViD-19 intensive care unit during the first phase of the pandemic participated.\n\nThe findings are presented within the four domains of person-centred practice: the prerequisites, the care environment, person-centred processes and person-centred outcomes. While the ambition and knowledge about how to work in accordance with person-centred practice were high, there were several obstacles to perform it.\n\nWe need to prepare ahead of time so that nurses have optimal organisational prerequisites to be able to work in accordance with person-centred practice, also during pandemics and other crisis, which means to be able to give nursing care in accordance with the ill person's needs and resources.", "doi": "10.1016/j.iccn.2021.103179", "pmid": "34895797", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(21)00168-3"}, {"db": "pmc", "key": "PMC8595352"}], "notes": [], "created": "2021-12-18T18:02:17.054Z", "modified": "2021-12-18T18:02:17.065Z"}, {"entity": "publication", "iuid": "3a3a2ac661554126906792aff64d19e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a3a2ac661554126906792aff64d19e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a3a2ac661554126906792aff64d19e2"}}, "title": "Flow as a Key Predictor of Subjective Well-Being Among Chinese University Students: A Chain Mediating Model.", "authors": [{"family": "Wu", "given": "Jun", "initials": "J"}, {"family": "Xie", "given": "Mei", "initials": "M"}, {"family": "Lai", "given": "Yao", "initials": "Y"}, {"family": "Mao", "given": "Yanhui", "initials": "Y"}, {"family": "Harmat", "given": "Laszlo", "initials": "L"}], "type": "journal article", "published": "2021-11-16", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "743906", "issn-l": "1664-1078"}, "abstract": "The present study investigated a conceptual model by testing flow experience and subjective well-being of university students during Coronavirus Diseas-19 (COVID-19) via considering their underlying mechanisms of academic self-efficacy and self-esteem. A total of 1,109 Chinese university students completed a questionnaire containing scales of subjective well-being, flow, academic self-efficacy, and self-esteem. Results yielded from the structural equation modeling analysis indicated a significant and positive association between flow experience and subjective well-being, and such an association was sequentially mediated by academic self-efficacy and self-esteem. Findings also provided empirical evidence for the proposed model highlighting the significant role of flow experience at the higher educational context in predicting subjective well-being of Chinese university students, and how such a relation can be supported by suggested mediating roles academic self-efficacy and self-esteem played.", "doi": "10.3389/fpsyg.2021.743906", "pmid": "34867624", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8636857"}], "notes": [], "created": "2021-12-12T07:06:54.204Z", "modified": "2021-12-12T07:06:54.218Z"}, {"entity": "publication", "iuid": "886aeb7ea151492486db7977a020afe9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/886aeb7ea151492486db7977a020afe9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/886aeb7ea151492486db7977a020afe9"}}, "title": "COVID-19 and risk of subsequent life-threatening secondary infections: a matched cohort study in UK Biobank.", "authors": [{"family": "Hou", "given": "Can", "initials": "C"}, {"family": "Hu", "given": "Yihan", "initials": "Y"}, {"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Chen", "given": "Wenwen", "initials": "W"}, {"family": "Zeng", "given": "Yu", "initials": "Y"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Sun", "given": "Yajing", "initials": "Y"}, {"family": "Qu", "given": "Yuanyuan", "initials": "Y"}, {"family": "Gottfre\u00f0sson", "given": "Magn\u00fas", "initials": "M"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "journal article", "published": "2021-11-16", "journal": {"title": "BMC Med", "issn": "1741-7015", "volume": "19", "issue": "1", "pages": "301", "issn-l": null}, "abstract": "With the increasing number of people infected with and recovered from coronavirus disease 2019 (COVID-19), the extent of major health consequences of COVID-19 is unclear, including risks of severe secondary infections.\n\nBased on 445,845 UK Biobank participants registered in England, we conducted a matched cohort study where 5151 individuals with a positive test result or hospitalized with a diagnosis of COVID-19 were included in the exposed group. We then randomly selected up to 10 matched individuals without COVID-19 diagnosis for each exposed individual (n = 51,402). The life-threatening secondary infections were defined as diagnoses of severe secondary infections with high mortality rates (i.e., sepsis, endocarditis, and central nervous system infections) from the UK Biobank inpatient hospital data, or deaths from these infections from mortality data. The follow-up period was limited to 3 months after the initial COVID-19 diagnosis. Using a similar study design, we additionally constructed a matched cohort where exposed individuals were diagnosed with seasonal influenza from either inpatient hospital or primary care data between 2010 and 2019 (6169 exposed and 61,555 unexposed individuals). After controlling for multiple confounders, Cox models were used to estimate hazard ratios (HRs) of life-threatening secondary infections after COVID-19 or seasonal influenza.\n\nIn the matched cohort for COVID-19, 50.22% of participants were male, and the median age at the index date was 66 years. During a median follow-up of 12.71 weeks, the incidence rate of life-threatening secondary infections was 2.23 (123/55.15) and 0.25 (151/600.55) per 1000 person-weeks for all patients with COVID-19 and their matched individuals, respectively, which corresponded to a fully adjusted HR of 8.19 (95% confidence interval [CI] 6.33-10.59). The corresponding HR of life-threatening secondary infections among all patients with seasonal influenza diagnosis was 4.50, 95% CI 3.34-6.08 (p for difference < 0.01). Also, elevated HRs were observed among hospitalized individuals for life-threatening secondary infections following hospital discharge, both in the COVID-19 (HR = 6.28 [95% CI 4.05-9.75]) and seasonal influenza (6.01 [95% CI 3.53-10.26], p for difference = 0.902) cohorts.\n\nCOVID-19 patients have increased subsequent risks of life-threatening secondary infections, to an equal extent or beyond risk elevations observed for patients with seasonal influenza.", "doi": "10.1186/s12916-021-02177-0", "pmid": "34781951", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12916-021-02177-0"}, {"db": "pmc", "key": "PMC8592806"}], "notes": [], "created": "2021-11-26T14:12:01.306Z", "modified": "2021-11-26T14:12:01.341Z"}, {"entity": "publication", "iuid": "ba2274ccc726426ea87ac013ad38e11c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ba2274ccc726426ea87ac013ad38e11c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ba2274ccc726426ea87ac013ad38e11c"}}, "title": "Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models.", "authors": [{"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Mandolesi", "given": "Marco", "initials": "M"}, {"family": "Urgard", "given": "Egon", "initials": "E"}, {"family": "Kim", "given": "Changil", "initials": "C"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Perez Vidakovics", "given": "Laura", "initials": "L"}, {"family": "Pankow", "given": "Alec", "initials": "A"}, {"family": "Smith", "given": "Natalie L", "initials": "NL"}, {"family": "Castro Dopico", "given": "Xaquin", "initials": "X"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}, {"family": "Coquet", "given": "Jonathan M", "initials": "JM"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Murrell", "given": "Ben", "initials": "B"}], "type": "journal article", "published": "2021-11-16", "journal": {"title": "Cell Rep Med", "issn": "2666-3791", "issn-l": "2666-3791", "volume": "2", "issue": "11", "pages": "100450"}, "abstract": "Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) with resistance to neutralizing antibodies are threatening to undermine vaccine efficacy. Vaccination and infection have led to widespread humoral immunity against the pandemic founder (Wu-Hu-1). Against this background, it is critical to assess the outcomes of subsequent immunization with variant antigens. It is not yet clear whether heterotypic boosts would be compromised by original antigenic sin, where pre-existing responses to a prior variant dampen responses to a new one, or whether the memory B cell repertoire would bridge the gap between Wu-Hu-1 and VOCs. We show, in macaques immunized with Wu-Hu-1 spike, that a single dose of adjuvanted beta variant receptor binding domain (RBD) protein broadens neutralizing antibody responses to heterologous VOCs. Passive transfer of plasma sampled after Wu-Hu-1 spike immunization only partially protects K18-hACE2 mice from lethal challenge with a beta variant isolate, whereas plasma sampled following heterotypic RBD boost protects completely against disease.", "doi": "10.1016/j.xcrm.2021.100450", "pmid": "34723224", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Funder: VR": null, "Category: Genomics & transcriptomics": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "S2666-3791(21)00318-9"}, {"db": "pmc", "key": "PMC8536561"}, {"db": "URL", "key": "https://github.com/MurrellGroup/VOCfreq", "description": "Code used for analyses"}], "notes": [], "created": "2021-11-02T15:33:54.198Z", "modified": "2021-11-18T13:48:31.567Z"}, {"entity": "publication", "iuid": "3828890895b942c8bd11d40e982ecb75", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3828890895b942c8bd11d40e982ecb75.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3828890895b942c8bd11d40e982ecb75"}}, "title": "Predicting Work-Life Conflict: Types and Levels of Enacted and Preferred Work-Nonwork Boundary (In)Congruence and Perceived Boundary Control.", "authors": [{"family": "Mellner", "given": "Christin", "initials": "C"}, {"family": "Peters", "given": "Pascale", "initials": "P"}, {"family": "Dragt", "given": "Maria Johanna", "initials": "MJ"}, {"family": "Toivanen", "given": "Susanna", "initials": "S"}], "type": "journal article", "published": "2021-11-15", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "772537", "issn-l": "1664-1078"}, "abstract": "In 2020, everyday life changed dramatically for employees worldwide as a result of the outbreak of the Covid-19 pandemic, where an estimated 558 million employees started working from home. The pandemic, therefore, marks a fundamental shift of individuals' work-nonwork boundaries, which can impact work-life conflict. In particular, the interplay between individuals' enacted boundaries (degree to which they separate/segment or blend/integrate work-nonwork), preferred boundaries (degree of preferred segmentation or integration of work-nonwork), and perceived control over work-nonwork boundaries, may relate to work-life conflict. This study, the first to the best of our knowledge, examines whether different types and levels of work-nonwork boundary (in)congruence matter for work-life conflict, and whether perceived boundary control moderates these relationships. Boundary (in)congruence represents the degree of (mis)fit between enacted and preferred segmentation or integration. Several types of (in)congruence are distinguished: \"segmentation congruence\" (enacting and preferring segmentation); \"integration congruence\" (enacting and preferring integration); \"intrusion\" (enacting integration but preferring segmentation) and \"distance\" (enacting segmentation but preferring integration). Data from 1,229 managers working in public and private organizations in Sweden was analyzed using polynomial regression analysis with response surface modeling and moderation analysis in SPSS Process. Findings showed that \"integration congruence\" was related with higher work-life conflict than \"segmentation congruence.\" Moreover, a U-shaped relationship between incongruence and work-life conflict was found: the more incongruence, the more work-life conflict. Specifically, \"intrusion\" was related to higher work-life conflict than \"distance.\" Finally, boundary control mitigated the effect of incongruence (especially \"intrusion\") on work-life conflict. From our findings, we may conclude that work-life conflict is impacted differently depending on the type and level of boundary (in)congruence. Particularly enacted and/or preferred integration may be problematic when it comes to work-life conflict, rather than just (in)congruence per se. Moreover, boundary control can be viewed as a key factor in combating work-life conflict, especially among individuals who enact integration, but prefer segmentation. Taken together, our study contributes new and substantial knowledge by showing the importance for research and HRM-policies that take into account different types and levels of boundary (in)congruence, as these are associated with different levels of work-life conflict, which, in turn, are moderated by boundary control.", "doi": "10.3389/fpsyg.2021.772537", "pmid": "34867680", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8636054"}], "notes": [], "created": "2021-12-12T07:08:00.780Z", "modified": "2021-12-12T07:08:00.794Z"}, {"entity": "publication", "iuid": "634ab65b283f4ad5ad0e20b5d53623ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/634ab65b283f4ad5ad0e20b5d53623ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/634ab65b283f4ad5ad0e20b5d53623ef"}}, "title": "Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know?", "authors": [{"family": "Bisaccia", "given": "Giandomenico", "initials": "G", "orcid": "0000-0003-4606-3093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9ff7c6f9a724caea1cae5493f4951af.json"}}, {"family": "Ricci", "given": "Fabrizio", "initials": "F", "orcid": "0000-0002-1401-6623", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1dab56ecc21e43909dcc6881ffef5892.json"}}, {"family": "Recce", "given": "Vittoria", "initials": "V"}, {"family": "Serio", "given": "Antonio", "initials": "A"}, {"family": "Iannetti", "given": "Giovanni", "initials": "G"}, {"family": "Chahal", "given": "Anwar A", "initials": "AA", "orcid": "0000-0001-7825-8827", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/792261f66ef641ab8f135eb75586ff38.json"}}, {"family": "St\u00e5hlberg", "given": "Marcus", "initials": "M"}, {"family": "Khanji", "given": "Mohammed Yunus", "initials": "MY"}, {"family": "Fedorowski", "given": "Artur", "initials": "A", "orcid": "0000-0002-5352-6327", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2ef9375bfba4311868834aec838c8a3.json"}}, {"family": "Gallina", "given": "Sabina", "initials": "S"}], "type": "journal article", "published": "2021-11-15", "journal": {"title": "J Cardiovasc Dev Dis", "issn": "2308-3425", "volume": "8", "issue": "11", "issn-l": null}, "abstract": "Post-acute sequelae of SARS-CoV-2 (PASC), or long COVID syndrome, is emerging as a major health issue in patients with previous SARS-CoV-2 infection. Symptoms commonly experienced by patients include fatigue, palpitations, chest pain, dyspnea, reduced exercise tolerance, and \"brain fog\". Additionally, symptoms of orthostatic intolerance and syncope suggest the involvement of the autonomic nervous system. Signs of cardiovascular autonomic dysfunction appear to be common in PASC and are similar to those observed in postural orthostatic tachycardia syndrome and inappropriate sinus tachycardia. In this review, we report on the epidemiology of PASC, discuss current evidence and possible mechanisms underpinning the dysregulation of the autonomic nervous system, and suggest nonpharmacological and pharmacological interventions to treat and relieve symptoms of PASC-associated dysautonomia.", "doi": "10.3390/jcdd8110156", "pmid": "34821709", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jcdd8110156"}, {"db": "pmc", "key": "PMC8621226"}], "notes": [], "created": "2021-11-26T13:04:49.442Z", "modified": "2021-12-18T18:20:39.207Z"}, {"entity": "publication", "iuid": "85651f060d974f45a6b00cb2151928c8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/85651f060d974f45a6b00cb2151928c8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/85651f060d974f45a6b00cb2151928c8"}}, "title": "COVID-19 water, sanitation, and hygiene response: Review of measures and initiatives adopted by governments, regulators, utilities, and other stakeholders in 84 countries.", "authors": [{"family": "Gin\u00e9-Garriga", "given": "Ricard", "initials": "R"}, {"family": "Delepiere", "given": "Antoine", "initials": "A"}, {"family": "Ward", "given": "Robin", "initials": "R"}, {"family": "Alvarez-Sala", "given": "Jorge", "initials": "J"}, {"family": "Alvarez-Murillo", "given": "Isabel", "initials": "I"}, {"family": "Mariezcurrena", "given": "Virginia", "initials": "V"}, {"family": "Sandberg", "given": "Henning G\u00f6ransson", "initials": "HG"}, {"family": "Saikia", "given": "Panchali", "initials": "P"}, {"family": "Avello", "given": "Pilar", "initials": "P"}, {"family": "Thakar", "given": "Kanika", "initials": "K"}, {"family": "Ibrahim", "given": "Esmaeil", "initials": "E"}, {"family": "Nouvellon", "given": "Alban", "initials": "A"}, {"family": "El Hattab", "given": "Omar", "initials": "O"}, {"family": "Hutton", "given": "Guy", "initials": "G"}, {"family": "Jim\u00e9nez", "given": "Alejandro", "initials": "A"}], "type": "journal article", "published": "2021-11-15", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "issn-l": "0048-9697", "volume": "795", "issue": null, "pages": "148789"}, "abstract": "The COVID-19 pandemic has shone a light on handwashing as an inexpensive, widely applicable response measure. In consequence, most governments have taken action to promote access to water and sanitation services for all. This paper documents an overview of initiatives and interventions that countries have implemented during the first months of the COVID-19 response. Initiatives have been identified across 84 countries worldwide, and categorized into those that aimed at securing water, sanitation, and hygiene (WASH) for all, and those that sought to provide technical and financial support to service providers. The pandemic has not hit countries in the same way. Accordingly, results show disparities in the response between and within regions, with the level of activity found in the countries varying largely in terms of ambition and scope. Hygiene promotion and infection prevention and control (IPC) has been widely adopted - at least one response measure found in 94% of mapped countries -, although not always matched in ambition with the assured availability of soap, water, and handwashing facilities. Support to vulnerable households to promote basic access to WASH services at scale was weak (38% of countries) or implemented locally (25%), and requiring additional focus, particularly in rural areas and small towns. In addition, parallel support needs to be extended to service providers or to households themselves in the form of cash transfers, in order to ensure the financial viability and the continuity of services. All lessons learned distilled from the pandemic should help strengthen the enabling environment for more resilient services in future emergencies. Areas for focus could include developing specific pandemic response strategies and plans; strengthening coordination; and establishing emergency financial support mechanisms for water operators, for example. Overall, findings presented herein contribute to enhance current and future pandemics prevention, mitigation, and recovery.", "doi": "10.1016/j.scitotenv.2021.148789", "pmid": "34243010", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(21)03861-4"}, {"db": "pmc", "key": "PMC8254381"}], "notes": [], "created": "2021-08-06T07:57:24.602Z", "modified": "2021-09-20T16:23:07.056Z"}, {"entity": "publication", "iuid": "3e7419528ada4d74b76965da0815779b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3e7419528ada4d74b76965da0815779b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3e7419528ada4d74b76965da0815779b"}}, "title": "COVID-19 vaccination in autoimmune disease (COVAD) survey protocol.", "authors": [{"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Aggarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-0986-8354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2e6226ae5e7427fbf52e180dd14e28f.json"}}, {"family": "Kardes", "given": "Sinan", "initials": "S", "orcid": "0000-0002-6311-8634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2900c3ca00da476a8914574384a3c9c2.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "O'Callaghan", "given": "Albert Selva", "initials": "AS", "orcid": "0000-0003-2823-9761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef3e202c049b44a2a5e045bac90a393a.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Cagnotto", "given": "Giovanni", "initials": "G", "orcid": "0000-0002-1682-8158", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91574e9defd848a78539eabd351940c1.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Aggarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-2089-027X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31cc5ee9caf34d889e61e31520b4399b.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "COVAD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-15", "journal": {"title": "Rheumatol Int", "issn": "1437-160X", "issn-l": null}, "abstract": "The coronavirus disease-2019 (COVID-19) pandemic continues to be a cause of unprecedented global morbidity and mortality. Whilst COVID-19 vaccination has emerged as the only tangible solution to reducing poor clinical outcomes, vaccine hesitancy continues to be an obstacle to achieving high levels of vaccine uptake. This represents particular risk to patients with autoimmune diseases, a group already at increased risk of hospitalization and poor clinical outcomes related to COVID-19 infection. Whilst there is a paucity of long-term safety and efficacy data of COVID-19 vaccination in patients with autoimmune diseases, the current evidence strongly suggests that the benefits of vaccination outweigh the risks of adverse effects and disease flares. Herein, we report the protocol of the COVID-19 Vaccination in Autoimmune Diseases (COVAD) study, an ongoing international collaborative study involving 29 countries and over 110 investigators.", "doi": "10.1007/s00296-021-05046-4", "pmid": "34779868", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00296-021-05046-4"}, {"db": "pmc", "key": "PMC8591970"}], "notes": [], "created": "2021-11-26T14:12:43.355Z", "modified": "2021-11-26T14:12:44.102Z"}, {"entity": "publication", "iuid": "58c44fae885640b0a222a91d48740176", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/58c44fae885640b0a222a91d48740176.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/58c44fae885640b0a222a91d48740176"}}, "title": "Utilization of health care services before and after media attention about fatal side effects of the AstraZeneca vaccine: a nation-wide register-based event study.", "authors": [{"family": "Larsen", "given": "Vilde Bergstad", "initials": "VB"}, {"family": "Gr\u00f8sland", "given": "Mari", "initials": "M"}, {"family": "Telle", "given": "Kjetil", "initials": "K"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2021-11-13", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "issn-l": null, "volume": "21", "issue": "1", "pages": "1229"}, "abstract": "Survey studies have found that vaccinated persons tend to report more side effects after being given information about side effects rather than benefits. However, the impact of high media attention about vaccine-related side effects on the utilization of health care is unknown. We aimed to assess whether utilization of health care services for newly vaccinated health care workers changed after media attention about fatal side effects of the AstraZeneca vaccine on March 11th, 2021, and whether changes differed by age, sex, or occupation.\r\n\r\nWe utilized individual-level data on health care use, vaccination, employment, and demographics available in the Norwegian emergency preparedness register Beredt C19. In all 99,899 health care workers in Norway who were vaccinated with AstraZeneca between February 11th and March 11th, we used an event-study design with a matched comparison group to compare the change in primary and inpatient specialist care use from 14 days before to 14 days after the information shock on March 11th, 2021.\r\n\r\nPrimary health care use increased with 8.2 daily consultations per 1000 health care workers (95% CI 7.51 to 8.89) the week following March 11th for those vaccinated with AstraZeneca (n = 99,899), compared with no increase for the unvaccinated comparison group (n = 186,885). Utilization of inpatient care also increased with 0.8 daily hospitalizations per 1000 health care workers (95% CI 0.37 to 1.23) in week two after March 11th. The sharpest increase in daily primary health care use in the first week after March 11th was found for women aged 18-44 (10.6 consultations per 1000, 95% CI 9.52 to 11.68) and for cleaners working in the health care sector (9.8 consultations per 1000, 95% CI 3.41 to 16.19).\r\n\r\nHealth care use was higher after the media reports of a few cases of fatal or severe side effects of the AstraZeneca vaccine. Our results suggest that the reports did not only lead vaccinated individuals to contact primary health care more, but also that physicians referred and treated more cases to specialist care after the new information.", "doi": "10.1186/s12913-021-07233-2", "pmid": "34774045", "labels": {"Type: Journal article": null, "Topics: Register-based research": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-021-07233-2"}, {"db": "pmc", "key": "PMC8590367"}], "notes": [], "created": "2021-11-26T15:07:46.550Z", "modified": "2021-11-29T06:06:38.104Z"}, {"entity": "publication", "iuid": "550af56a537a48ef9b110f14802614cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/550af56a537a48ef9b110f14802614cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/550af56a537a48ef9b110f14802614cb"}}, "title": "Just how common is TTS after a second dose of the ChAdOx1 nCov-19 vaccine? - Authors' reply.", "authors": [{"family": "Bhuyan", "given": "Prakash", "initials": "P"}, {"family": "Medin", "given": "Jennie", "initials": "J"}, {"family": "da Silva", "given": "Hugo Gomes", "initials": "HG"}, {"family": "Yadavalli", "given": "Madhavi", "initials": "M"}, {"family": "Nord", "given": "Magnus", "initials": "M"}], "type": "letter", "published": "2021-11-13", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "398", "issue": "10313", "pages": "1801-1802", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(21)02317-5", "pmid": "34774142", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)02317-5"}], "notes": [], "created": "2021-11-26T14:29:42.406Z", "modified": "2021-11-26T14:29:42.420Z"}, {"entity": "publication", "iuid": "194df91105ef49e1ad019cfe7228e489", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/194df91105ef49e1ad019cfe7228e489.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/194df91105ef49e1ad019cfe7228e489"}}, "title": "General stress among young adults with asthma during the COVID-19 pandemic.", "authors": [{"family": "Ekstr\u00f6m", "given": "Sandra", "initials": "S"}, {"family": "Mogensen", "given": "Ida", "initials": "I"}, {"family": "Georgelis", "given": "Antonios", "initials": "A"}, {"family": "Westman", "given": "Marit", "initials": "M"}, {"family": "Almqvist", "given": "Catarina", "initials": "C"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Bergstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "BAMSE COVID-19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-13", "journal": {"title": "J Allergy Clin Immunol Pract", "issn": "2213-2201", "issn-l": null}, "abstract": "The COVID-19 pandemic has profoundly affected the lives of the global population.\n\nTo explore anxiety and stress in relation to COVID-19 among young adults, and the potential influence of asthma and allergic rhinitis.\n\nThis cross-sectional study included 1,644 participants from the population-based birth cohort BAMSE, participating in a follow-up at 24 years of age and a COVID-19 follow-up conducted in August-November 2020 (mean age 25.3 years). Anxiety and concern related to COVID-19 were analyzed as general anxiety, concern of own health and health of family members, and contact with online healthcare providers due to concern about COVID-19. Stress was measured with the perceived stress scale (PSS-10).\n\nAround half of the participants reported increased anxiety due to COVID-19 and this was more common among females (57.0%, compared to 42.6% in males, p<0.001). Young adults with asthma reported more concern about their own health (adjusted odds ratio (adj OR): 1.50, 95% confidence interval (CI): 1.12-2.02) and perceived stress (adjusted regression coefficient (adj \u03b2): 1.49 CI: 0.52-2.45) compared to peers without asthma, and this was more pronounced among females and those with uncontrolled asthma. Symptoms of allergic rhinitis were not associated with increased concern or anxiety in relation to COVID-19.\n\nYoung adults with asthma experience more COVID-19 related health concerns, compared to those without asthma; especially females and participants with uncontrolled asthma This needs to be considered in the care of young people with asthma.", "doi": "10.1016/j.jaip.2021.10.069", "pmid": "34785389", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2213-2198(21)01260-5"}, {"db": "pmc", "key": "PMC8590620"}], "notes": [], "created": "2021-11-26T14:11:36.607Z", "modified": "2021-11-26T14:11:36.621Z"}, {"entity": "publication", "iuid": "0dcc8509723f41338670ce7ef4e5bb71", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0dcc8509723f41338670ce7ef4e5bb71.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0dcc8509723f41338670ce7ef4e5bb71"}}, "title": "Gaming Activity and Possible Changes in Gaming Behavior Among Young People During the COVID-19 Pandemic: Cross-sectional Online Survey Study.", "authors": [{"family": "Claesdotter-Knutsson", "given": "Emma", "initials": "E"}, {"family": "Andr\u00e9", "given": "Frida", "initials": "F"}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-11-13", "journal": {"title": "JMIR Serious Games", "issn": "2291-9279", "issn-l": null}, "abstract": "Young people's daily lives and social interactions changed remarkably during the COVID-19 pandemic as schools and cinemas closed, leisure activities were cancelled, and gatherings were regulated. Questions have been raised by the media, schools, policymakers and research communities about the effect on young people's online behaviors.\n\nThe aim of this cross-sectional study was to study self-reported changes in gaming, focusing on a younger section of the population during the COVID-19 pandemic in Sweden. We also wanted to look at potential risk factors behind problematic gaming during the pandemic, including gaming patterns, gambling behavior, psychological distress, certain sociodemographic characteristics, health factors, and school situation.\n\nThis was an anonymous online survey study of web panel participants in Sweden (N=1,501) to study changes in gaming behaviors during the COVID-19 pandemic. Self-reported increases in gaming were analyzed in logistic regressions against sociodemographic and health factors.\n\nWithin the whole study population that reported changes in gaming activity we found significant differences in age, employment status, disposable income, whether they ever played on loot boxes, time spent at home, school attendance, psychological distress, gambling and gaming problems, and significant differences in changes in alcohol consumption and changes in exercise habits. When examining the age group 16-24 years old that reported changes in gaming activity, we found significant differences within the group in disposable income, time at home and school attendance. When examining the age group 25-39 years old that reported changes in gaming activity, we found significant differences within the group in employment status, disposable income, time spent at home, whether the respondents are studying, school attendance level, psychological distress, gaming problems, as well as significant differences in changes in alcohol consumption and changes in exercise habits. Psychological distress (all age groups analyzed together; age group 25-39 years old), drinking less alcohol (all age groups analyzed together), spending more time at home (all age groups analyzed together), gaming problems and exercising less (age group 25-39 years old) were positively correlated to a self-reported increase in gaming activity. Being employed (age group 25-39 years old) and being over 40 years of age (all age groups analyzed together) were negatively correlated to increased gaming. We found no significant correlations in the age group 16-24 years old.\n\nThose who reported increased gaming during the COVID-19 pandemic were more likely to be 16-39 years old. In the age group 25-39 years old the increase was associated with psychological distress, reporting less exercise and being unemployed. COVID-19 may present a risk factor of increased online gaming in a small but vulnerable group. More research and preferably longitudinal studies are needed in the field of gaming and effects of the COVID-19 pandemic.", "doi": "10.2196/33059", "pmid": "34817386", "labels": {"Type: Journal article": null, "Category: Other": null, "Topics: Register-based research": null}, "xrefs": [], "notes": [], "created": "2021-11-26T13:06:15.801Z", "modified": "2021-12-18T18:22:51.084Z"}, {"entity": "publication", "iuid": "be53c97c1d794cc586bdddce6d92d246", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be53c97c1d794cc586bdddce6d92d246.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be53c97c1d794cc586bdddce6d92d246"}}, "title": "Beneficial Effects of Anticoagulants on the Clinical Outcomes of COVID-19 Patients.", "authors": [{"family": "Jamil", "given": "Zubia", "initials": "Z"}, {"family": "Khan", "given": "Azmat Ali", "initials": "AA", "orcid": "0000-0001-5955-3783", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fbf30007a9a4702b4fb2171acf8b7a4.json"}}, {"family": "Khalid", "given": "Samreen", "initials": "S"}, {"family": "Asghar", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-9017-2206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0e95806bb4a4dca8363a6d9618c678d.json"}}, {"family": "Muhammad", "given": "Khalid", "initials": "K", "orcid": "0000-0001-6488-1722", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a33153a6137841cbaec30e195174ddff.json"}}, {"family": "Waheed", "given": "Yasir", "initials": "Y", "orcid": "0000-0002-5789-4215", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9dc6b28db595446b8d4fd02142a077e0.json"}}], "type": "journal article", "published": "2021-11-13", "journal": {"title": "Antibiotics (Basel)", "issn": "2079-6382", "volume": "10", "issue": "11", "issn-l": null}, "abstract": "(1) Background: Severe coronavirus disease can be complicated by a hypercoagulable state in conjunction with sepsis, increasing the risk of venous thromboembolism. This study aimed to observe the effect of anticoagulants on 30-day high-dependency unit (HDU) outcomes of moderate to severe coronavirus disease 2019 (COVID-19) patients of a tertiary care hospital at Rawalpindi, Pakistan. (2) Methods: A retrospective propensity-based case-control study was carried out to examine COVID-19 patients admitted to the HDU. Patient groups who did and did not receive anticoagulants were labeled as \"anticoagulant\" and \"non-anticoagulant\", respectively. Case-control matching (1:1) was performed via propensity scores (calculated by a regression model). Kaplan-Meier and logrank analyses were used to study survival probability. Single predictors of outcomes were determined by Cox regression analysis. (3) Results: The anticoagulant group had elevated D-dimers, advanced age, more comorbidities and a higher frequency of severe disease compared to the non-anticoagulant group (p < 0.05). Therefore, 47 cases and 47 matched controls were selected based on their propensity scores. The primary endpoint was outcome (survived vs. died). The 30-day in-HDU mortality was 25.5% for cases and 61.7% for controls (p = 0.0004). The median time from admission to death was 16 days for the case group and 7 days for the control group (p < 0.0001). The 30-day mortality was 19.1% for the enoxaparin group and 16.4% for the heparin group (p > 0.05). Enoxaparin (therapeutic and prophylactic doses) and heparin (prophylactic dose) were found to be independent factors affecting the outcomes of these patients (p < 0.001). (4) Conclusions: Anticoagulants play a beneficial role in reducing mortality among COVID-19 patients. Both anticoagulant formulations, enoxaparin (therapeutic and prophylactic doses) and heparin (prophylactic dose), were associated with improving survival among these patients.", "doi": "10.3390/antibiotics10111394", "pmid": "34827332", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "antibiotics10111394"}, {"db": "pmc", "key": "PMC8615249"}], "notes": [], "created": "2021-12-18T18:17:40.214Z", "modified": "2021-12-18T18:17:40.354Z"}, {"entity": "publication", "iuid": "aa0ac8acb86d4d32907c7a91390df8c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aa0ac8acb86d4d32907c7a91390df8c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aa0ac8acb86d4d32907c7a91390df8c0"}}, "title": "Partial oral antibiotic treatment for bacterial brain abscess: an open-label randomized non-inferiority trial (ORAL).", "authors": [{"family": "Bodilsen", "given": "Jacob", "initials": "J", "orcid": "0000-0002-7398-814X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d14a292f44b4962bb6d543d059debc8.json"}}, {"family": "Brouwer", "given": "Matthijs C", "initials": "MC"}, {"family": "van de Beek", "given": "Diederik", "initials": "D"}, {"family": "Tattevin", "given": "Pierre", "initials": "P"}, {"family": "Tong", "given": "Steven", "initials": "S"}, {"family": "Naucler", "given": "Pontus", "initials": "P"}, {"family": "Nielsen", "given": "Henrik", "initials": "H"}], "type": "equivalence trial", "published": "2021-11-12", "journal": {"title": "Trials", "issn": "1745-6215", "volume": "22", "issue": "1", "pages": "796", "issn-l": null}, "abstract": "The advised standard treatment for bacterial brain abscess following surgery is 6 to 8 weeks of intravenous (IV) antibiotic treatment, but an early switch to oral antibiotic treatment has been suggested to be equally effective.\n\nThis investigator-initiated, international, multi-center, parallel group, open-label, randomized (1:1 allocation) controlled trial will examine if oral treatment after 2 weeks of IV antibiotic therapy is non-inferior to standard 6-8 weeks of IV antibiotics for bacterial brain abscess in adults (\u2265 18 years of age). The study will be conducted at hospitals across Denmark, the Netherlands, France, Australia, and Sweden. Exclusion criteria are severe immunocompromise or impaired gastro-intestinal absorption, pregnancy, device-related brain abscesses, and brain abscess caused by nocardia, tuberculosis, or Pseudomonas spp. The primary objective is a composite endpoint at 6 months after randomization consisting of all-cause mortality, intraventricular rupture of brain abscess, unplanned re-aspiration or excision of brain abscess, relapse, or recurrence. The primary endpoint will be adjudicated by an independent blinded endpoint committee. Secondary outcomes include extended Glasgow Outcome Scale scores and all-cause mortality at end of treatment as well as 3, 6, and 12 months since randomization, completion of assigned treatment, IV catheter associated complications, durations of admission and antibiotic treatment, severe adverse events, quality of life scores, and cognitive evaluations. The planned sample size is 450 patients for a one-sided alpha of 0.025 and a power of 90% to exclude a difference in favor of standard treatment of more than 10%. Date of initiation of first study center was November 3, 2020, with active recruitment for 3 years and follow-up for 1 year of all patients.\n\nThe results of this study may guide future recommendations for treatment of bacterial brain abscess. If early transition to oral antibiotics proves non-inferior to standard IV treatment, this will provide considerable health and costs benefits.\n\nClinicalTrials.gov NCT04140903, first registered 28.10.2019. EudraCT number: 2019-002845-39, first registered 03.07.2019.", "doi": "10.1186/s13063-021-05783-8", "pmid": "34772441", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13063-021-05783-8"}, {"db": "pmc", "key": "PMC8588941"}, {"db": "ClinicalTrials.gov", "key": "NCT04140903"}], "notes": [], "created": "2021-11-26T15:08:14.926Z", "modified": "2021-11-26T15:08:14.985Z"}, {"entity": "publication", "iuid": "00e2bf08d8c844b4a437f7a44ec4e7d2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/00e2bf08d8c844b4a437f7a44ec4e7d2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/00e2bf08d8c844b4a437f7a44ec4e7d2"}}, "title": "The association between first and second wave COVID-19 mortality in Italy.", "authors": [{"family": "Vinceti", "given": "Marco", "initials": "M", "orcid": "0000-0002-0551-2473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a25953d69dcd4b9bb597385be88340bc.json"}}, {"family": "Filippini", "given": "Tommaso", "initials": "T", "orcid": "0000-0003-2100-0344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/caaa012b164e4fe3962d2cce410cd008.json"}}, {"family": "Rothman", "given": "Kenneth J", "initials": "KJ", "orcid": "0000-0003-2398-1705", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60d1be3be5cd4d40a4bd796f7b5faed1.json"}}, {"family": "Di Federico", "given": "Silvia", "initials": "S"}, {"family": "Orsini", "given": "Nicola", "initials": "N", "orcid": "0000-0002-2210-5634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6161818f1f74a26883d3b1e37e72f2e.json"}}], "type": "journal article", "published": "2021-11-11", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "21", "issue": "1", "pages": "2069", "issn-l": null}, "abstract": "The relation between the magnitude of successive waves of the COVID-19 outbreak within the same communities could be useful in predicting the scope of new outbreaks.\n\nWe investigated the extent to which COVID-19 mortality in Italy during the second wave was related to first wave mortality within the same provinces. We compared data on province-specific COVID-19 2020 mortality in two time periods, corresponding to the first wave (February 24-June 30, 2020) and to the second wave (September 1-December 31, 2020), using cubic spline regression.\n\nFor provinces with the lowest crude mortality rate in the first wave (February-June), i.e. < 22 cases/100,000/month, mortality in the second wave (September-December) was positively associated with mortality during the first wave. In provinces with mortality greater than 22/100,000/month during the first wave, higher mortality in the first wave was associated with a lower second wave mortality. Results were similar when the analysis was censored at October 2020, before the implementation of region-specific measures against the outbreak. Neither vaccination nor variant spread had any role during the study period.\n\nThese findings indicate that provinces with the most severe initial COVID-19 outbreaks, as assessed through mortality data, faced milder second waves.", "doi": "10.1186/s12889-021-12126-4", "pmid": "34763690", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-12126-4"}, {"db": "pmc", "key": "PMC8582237"}], "notes": [], "created": "2021-11-26T15:15:22.465Z", "modified": "2021-11-26T15:15:22.635Z"}, {"entity": "publication", "iuid": "30a7a3647f8048f39edc4c8f51995693", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/30a7a3647f8048f39edc4c8f51995693.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/30a7a3647f8048f39edc4c8f51995693"}}, "title": "Does COVID-19 cause pre-eclampsia?", "authors": [{"family": "Khalil", "given": "A", "initials": "A", "orcid": "0000-0003-2802-7670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e4558e368114cfb83c4594f523b38c0.json"}}, {"family": "Samara", "given": "A", "initials": "A"}, {"family": "Chowdhury", "given": "T", "initials": "T"}, {"family": "O'Brien", "given": "P", "initials": "P"}], "type": "journal article", "published": "2021-11-11", "journal": {"title": "Ultrasound Obstet Gynecol", "issn": "1469-0705", "issn-l": null}, "abstract": null, "doi": "10.1002/uog.24809", "pmid": "34766403", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-11-26T15:14:32.705Z", "modified": "2021-11-26T15:14:32.763Z"}, {"entity": "publication", "iuid": "cf772b0823c44d21af699e5a1a2d38f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cf772b0823c44d21af699e5a1a2d38f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cf772b0823c44d21af699e5a1a2d38f2"}}, "title": "Conducting In-Depth Interviews via Mobile Phone with Persons with Common Mental Disorders and Multimorbidity: The Challenges and Advantages as Experienced by Participants and Researchers.", "authors": [{"family": "Azad", "given": "Azad\u00e9", "initials": "A"}, {"family": "Sernbo", "given": "Elisabet", "initials": "E"}, {"family": "Sv\u00e4rd", "given": "Veronica", "initials": "V", "orcid": "0000-0002-3868-0254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7ca2d10512349b99cee9e0f1c5dc274.json"}}, {"family": "Holmlund", "given": "Lisa", "initials": "L", "orcid": "0000-0001-8321-0174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53f74a6dae5e489782ca1566f3edea16.json"}}, {"family": "Bj\u00f6rk Br\u00e4mberg", "given": "Elisabeth", "initials": "E", "orcid": "0000-0002-0204-5144", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ecc3851dd7b44208efeea67732361a3.json"}}], "type": "journal article", "published": "2021-11-11", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "22", "issn-l": null}, "abstract": "Qualitative interviews are generally conducted in person. As the coronavirus pandemic (COVID-19) prevents in-person interviews, methodological studies which investigate the use of the telephone for persons with different illness experiences are needed. The aim was to explore experiences of the use of telephone during semi-structured research interviews, from the perspective of participants and researchers. Data were collected from mobile phone interviews with 32 individuals who had common mental disorders or multimorbidity which were analyzed thematically, as well as field notes reflecting researchers' experiences. The findings reveal several advantages of conducting interviews using mobile phones: flexibility, balanced anonymity and power relations, as well as a positive effect on self-disclosure and emotional display (leading to less emotional work and social responsibility). Challenges included the loss of human encounter, intense listening, and worries about technology, as well as sounds or disturbances in the environment. However, the positive aspects of not seeing each other were regarded as more important. In addition, we present some strategies before, during, and after conducting telephone interviews. Telephone interviews can be a valuable first option for data collection, allowing more individuals to be given a fair opportunity to share their experiences.", "doi": "10.3390/ijerph182211828", "pmid": "34831582", "labels": {"Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182211828"}, {"db": "pmc", "key": "PMC8619936"}], "notes": [], "created": "2021-12-18T18:16:12.225Z", "modified": "2021-12-18T18:16:12.357Z"}, {"entity": "publication", "iuid": "f49303d656f140cfa8c868576cd1316b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f49303d656f140cfa8c868576cd1316b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f49303d656f140cfa8c868576cd1316b"}}, "title": "Potential impact of the COVID-19 pandemic on the national and regional incidence, epidemiology and diagnostic testing of chlamydia and gonorrhoea in Sweden, 2020.", "authors": [{"family": "Saarentausta", "given": "Katariina", "initials": "K"}, {"family": "Ivarsson", "given": "Lovisa", "initials": "L"}, {"family": "Jacobsson", "given": "Susanne", "initials": "S"}, {"family": "Herrmann", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Sundqvist", "given": "Martin", "initials": "M"}, {"family": "Unemo", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-11-10", "journal": {"title": "APMIS", "issn": "1600-0463", "issn-l": null}, "abstract": "The COVID-19 pandemic has challenged the societies and health care systems globally, and resulted in many social and physical distancing restrictions to limit the spread of SARS-CoV-2. These restrictions have also likely affected the frequency of intimate contacts and the spread of sexually transmitted infections (STIs). Compared to most other countries, Sweden especially in Spring-Autumn 2020 pursued mainly milder voluntary, that is, not mandatory enforced by laws, recommended restrictions and the impacts of these on society and spread of STIs remain largely unknown. We describe the potential impact of the COVID-19 pandemic on the national and regional incidence, epidemiology and diagnostic testing of chlamydia and gonorrhoea in Sweden in 2020. Compared to 2019, we found a significant decrease in incidence of chlamydia (-4.5%) and gonorrhoea (-17.5%), and in diagnostic testing (-10.5% for chlamydia, -9.4% for gonorrhoea) in 2020. However, the decrease in chlamydia incidence, which has mainly been decreasing in the last 10 years, was not significant when compared with the average incidence in 2017-2019. The largest decrease in national incidence of both infections was observed among young and heterosexual patients, however, some Swedish regions showed an increased incidence, particularly of chlamydia. Increased \"internet-based self-sampling\" testing approach partly compensated for a decreased attendance at STI clinics. Studies, including sexual behaviour, prevention, reasons for attending STI health care, STIs in different anatomical sites and management of STIs, are required to elucidate the impact of COVID-19-associated social and physical distancing restrictions on sexual activity and the incidence and epidemiology of chlamydia and gonorrhoea in Sweden.", "doi": "10.1111/apm.13191", "pmid": "34758169", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T15:22:34.410Z", "modified": "2021-11-26T15:22:34.431Z"}, {"entity": "publication", "iuid": "53dd7dfa906448b1aea795e4962f0f89", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53dd7dfa906448b1aea795e4962f0f89.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53dd7dfa906448b1aea795e4962f0f89"}}, "title": "Impacts of mild and severe COVID-19 on sick leave.", "authors": [{"family": "Skyrud", "given": "Katrine", "initials": "K", "orcid": "0000-0001-7504-9253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa7b45c41c544ba098093febd55117c8.json"}}, {"family": "Telle", "given": "Kjetil", "initials": "K"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2021-11-10", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "issn-l": "0300-5771", "volume": "50", "issue": "5", "pages": "1745-1747"}, "abstract": null, "doi": "10.1093/ije/dyab182", "pmid": "34458903", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6359516"}, {"db": "pmc", "key": "PMC8499817"}], "notes": [], "created": "2021-09-01T07:47:46.351Z", "modified": "2021-11-18T13:50:25.240Z"}, {"entity": "publication", "iuid": "b272ffc2e1ba4ad9b0ea7696c08ed7bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b272ffc2e1ba4ad9b0ea7696c08ed7bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b272ffc2e1ba4ad9b0ea7696c08ed7bf"}}, "title": "From chaos to control - experiences of healthcare workers during the early phase of the COVID-19 pandemic: a focus group study.", "authors": [{"family": "R\u00fccker", "given": "Fredrik", "initials": "F"}, {"family": "H\u00e5rdstedt", "given": "Maria", "initials": "M"}, {"family": "R\u00fccker", "given": "Sekai Chenai Mathabire", "initials": "SCM"}, {"family": "Aspelin", "given": "Emma", "initials": "E"}, {"family": "Smirnoff", "given": "Alexander", "initials": "A"}, {"family": "Lindblom", "given": "Anders", "initials": "A"}, {"family": "Gustavsson", "given": "Catharina", "initials": "C", "orcid": "0000-0002-8709-4446", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ccad80107b2d47289e4a795a8dfb4a26.json"}}], "type": "journal article", "published": "2021-11-10", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "volume": "21", "issue": "1", "pages": "1219", "issn-l": null}, "abstract": "The Coronavirus disease 2019 (COVID-19) pandemic has caused overwhelming challenges to healthcare systems worldwide. Healthcare workers (HCWs) have faced particular challenges: being exposed to the coronavirus SARS-CoV-2 and caring for patients having a new and potentially life-threatening disease. The aim of this study was to explore how HCWs in the Swedish healthcare system perceived their work situation during the first phase of the COVID-19 pandemic in 2020.\n\nFocus group discussions and interviews with HCWs were performed from June to October 2020 in one Swedish healthcare region. A purposeful sampling approach was used to select a variety of professions (physicians, nurses, nurse aides and cleaners) and workplaces (hospital inpatient wards, emergency department, nursing home and home care service). Qualitative content analysis was used for data analysis.\n\nIn total, 51 HCWs participated in eight focus group discussions and one HCW participated in an individual interview. The content analysis identified two main categories: 'Concerns about the risk of infection and transmission of infection to others', and 'Transition from chaos to managing in a new and challenging work situation'. The findings revealed how HCWs perceived working conditions, including experiences of fear for personal health, confusion and uncertainty regarding personal protective equipment and infection prevention and control (PPE/IPC), and fear of infecting others. Both fearful and appreciating attitudes were achieved from the surrounding community. Helpful strategies for transition from chaos to control were lifted i.e. present and supportive leadership, and finding comfort and strength in the working team. Both helplessness and meaningfulness were described when caring for COVID-19 patients.\n\nThis study provides unique insights into HCWs experiences of an extremely challenging work situation during the first phase of the COVID-19 pandemic, including feelings of stress and insecurity in a chaotic and hazardous working environment. But there is also mitigation of these challenges and even positive experiences including feelings of safety and meaningfulness. To enhance safety among HCWs in healthcare crises such as the COVID-19 pandemic, the findings highlight the importance of avoiding confusion about PPE/IPC, having a supportive healthcare leadership and ensuring accurate information provision about virus transmission to the public.", "doi": "10.1186/s12913-021-07248-9", "pmid": "34758837", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-021-07248-9"}, {"db": "pmc", "key": "PMC8579171"}], "notes": [], "created": "2021-11-26T15:22:04.914Z", "modified": "2021-11-26T15:22:04.968Z"}, {"entity": "publication", "iuid": "c1a3fc23659846ab983c7656417045fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1a3fc23659846ab983c7656417045fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1a3fc23659846ab983c7656417045fc"}}, "title": "Fear of COVID-19 lead to procrastination among Turkish university students: The mediating role of intolerance of uncertainty.", "authors": [{"family": "Do\u011fan\u00fclk\u00fc", "given": "Hac\u0131 Arif", "initials": "HA"}, {"family": "Korkmaz", "given": "Ozan", "initials": "O"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-11-10", "journal": {"title": "BMC Psychol", "issn": "2050-7283", "volume": "9", "issue": "1", "pages": "178", "issn-l": null}, "abstract": "The COVID-19 outbreak has not only increased mortality but has also negatively affected mental health among populations across the world. Furthermore, individuals are experiencing uncertainty about their current and future situation because of the pandemic. Therefore, the present study investigated the mediating role of intolerance of uncertainty in the relationship between fear of COVID-19 and procrastination among a sample of Turkish university students.\n\nBetween October and November 2020, 450 university students (291 females and 159 males aged 17 to 24 years) from three state universities in Turkey completed an online survey. Correlation analysis and structural equation modeling methods were employed to examine a model for understanding the general procrastination during COVID-19 pandemic.\n\nThe results of the correlation analysis indicated that the fear of COVID-19 was positively correlated with both intolerance of uncertainty (r = .26, p < .001) and procrastination (r = .23, p < .001). The mediation analysis also showed that intolerance of uncertainty had a significant mediating role in the relationship between fear of COVID-19 and procrastination (\u03b2 = .11, p < .001).\n\nReducing the fear of COVID-19 and intolerance of uncertainty is likely to contribute to reducing individuals' procrastination behaviors during the pandemic.", "doi": "10.1186/s40359-021-00681-9", "pmid": "34758865", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s40359-021-00681-9"}, {"db": "pmc", "key": "PMC8579725"}], "notes": [], "created": "2021-11-26T15:21:49.770Z", "modified": "2021-11-26T15:21:49.804Z"}, {"entity": "publication", "iuid": "82f55ec89a3747aaa9cc0ee95306a936", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82f55ec89a3747aaa9cc0ee95306a936.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82f55ec89a3747aaa9cc0ee95306a936"}}, "title": "Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trial.", "authors": [{"family": "Granholm", "given": "Anders", "initials": "A", "orcid": "0000-0001-5799-7655", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d058ecb91d4c482abbee511b044ddf75.json"}}, {"family": "Munch", "given": "Marie Warrer", "initials": "MW"}, {"family": "Myatra", "given": "Sheila Nainan", "initials": "SN"}, {"family": "Vijayaraghavan", "given": "Bharath Kumar Tirupakuzhi", "initials": "BKT"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Wahlin", "given": "Rebecka Rubenson", "initials": "RR"}, {"family": "Jakob", "given": "Stephan M", "initials": "SM"}, {"family": "Cioccari", "given": "Luca", "initials": "L"}, {"family": "Kj\u00e6r", "given": "Maj-Brit N\u00f8rregaard", "initials": "MN"}, {"family": "Vesterlund", "given": "Gitte Kingo", "initials": "GK"}, {"family": "Meyhoff", "given": "Tine Sylvest", "initials": "TS"}, {"family": "Helleberg", "given": "Marie", "initials": "M"}, {"family": "M\u00f8ller", "given": "Morten Hylander", "initials": "MH"}, {"family": "Benfield", "given": "Thomas", "initials": "T"}, {"family": "Venkatesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Hammond", "given": "Naomi E", "initials": "NE"}, {"family": "Micallef", "given": "Sharon", "initials": "S"}, {"family": "Bassi", "given": "Abhinav", "initials": "A"}, {"family": "John", "given": "Oommen", "initials": "O"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Kristiansen", "given": "Klaus Tjelle", "initials": "KT"}, {"family": "Ulrik", "given": "Charlotte Suppli", "initials": "CS"}, {"family": "J\u00f8rgensen", "given": "Vibeke Lind", "initials": "VL"}, {"family": "Smitt", "given": "Margit", "initials": "M"}, {"family": "Bestle", "given": "Morten H", "initials": "MH"}, {"family": "Andreasen", "given": "Anne Sofie", "initials": "AS"}, {"family": "Poulsen", "given": "Lone Musaeus", "initials": "LM"}, {"family": "Rasmussen", "given": "Bodil Steen", "initials": "BS"}, {"family": "Br\u00f8chner", "given": "Anne Craveiro", "initials": "AC"}, {"family": "Str\u00f8m", "given": "Thomas", "initials": "T"}, {"family": "M\u00f8ller", "given": "Anders", "initials": "A"}, {"family": "Khan", "given": "Mohd Saif", "initials": "MS"}, {"family": "Padmanaban", "given": "Ajay", "initials": "A"}, {"family": "Divatia", "given": "Jigeeshu Vasishtha", "initials": "JV"}, {"family": "Saseedharan", "given": "Sanjith", "initials": "S"}, {"family": "Borawake", "given": "Kapil", "initials": "K"}, {"family": "Kapadia", "given": "Farhad", "initials": "F"}, {"family": "Dixit", "given": "Subhal", "initials": "S"}, {"family": "Chawla", "given": "Rajesh", "initials": "R"}, {"family": "Shukla", "given": "Urvi", "initials": "U"}, {"family": "Amin", "given": "Pravin", "initials": "P"}, {"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Wamberg", "given": "Christian Aage", "initials": "CA"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Lange", "given": "Theis", "initials": "T"}, {"family": "Perner", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-11-10", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "issn-l": "0342-4642"}, "abstract": "We compared dexamethasone 12 versus 6 mg daily for up to 10 days in patients with coronavirus disease 2019 (COVID-19) and severe hypoxaemia in the international, randomised, blinded COVID STEROID 2 trial. In the primary, conventional analyses, the predefined statistical significance thresholds were not reached. We conducted a pre-planned Bayesian analysis to facilitate probabilistic interpretation.\n\nWe analysed outcome data within 90 days in the intention-to-treat population (data available in 967 to 982 patients) using Bayesian models with various sensitivity analyses. Results are presented as median posterior probabilities with 95% credible intervals (CrIs) and probabilities of different effect sizes with 12 mg dexamethasone.\n\nThe adjusted mean difference on days alive without life support at day 28 (primary outcome) was 1.3 days (95% CrI -0.3 to 2.9; 94.2% probability of benefit). Adjusted relative risks and probabilities of benefit on serious adverse reactions was 0.85 (0.63 to 1.16; 84.1%) and on mortality 0.87 (0.73 to 1.03; 94.8%) at day 28 and 0.88 (0.75 to 1.02; 95.1%) at day 90. Probabilities of benefit on days alive without life support and days alive out of hospital at day 90 were 85 and 95.7%, respectively. Results were largely consistent across sensitivity analyses, with relatively low probabilities of clinically important harm with 12 mg on all outcomes in all analyses.\n\nWe found high probabilities of benefit and low probabilities of clinically important harm with dexamethasone 12 mg versus 6 mg daily in patients with COVID-19 and severe hypoxaemia on all outcomes up to 90 days.", "doi": "10.1007/s00134-021-06573-1", "pmid": "34757439", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-021-06573-1"}, {"db": "pmc", "key": "PMC8579417"}, {"db": "ClinicalTrials.gov", "key": "NCT04509973"}, {"db": "CTRI", "key": "CTRI/2020/10/028731"}], "notes": [], "created": "2021-11-26T15:22:50.796Z", "modified": "2021-11-26T15:22:50.839Z"}, {"entity": "publication", "iuid": "44db6ce5a85b416fb6d9dbeff3b0ba79", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44db6ce5a85b416fb6d9dbeff3b0ba79.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44db6ce5a85b416fb6d9dbeff3b0ba79"}}, "title": "Crosstalk between the renin-angiotensin, complement and kallikrein-kinin systems in inflammation.", "authors": [{"family": "Bekassy", "given": "Zivile", "initials": "Z", "orcid": "0000-0002-5942-281X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/66f1635f53944e9b9bea08d62caa4f17.json"}}, {"family": "Lopatko Fagerstr\u00f6m", "given": "Ingrid", "initials": "I"}, {"family": "Bader", "given": "Michael", "initials": "M"}, {"family": "Karpman", "given": "Diana", "initials": "D", "orcid": "0000-0001-7220-7658", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a7a12da87fb48359206955185eb7b4e.json"}}], "type": "journal article", "published": "2021-11-10", "journal": {"title": "Nat Rev Immunol", "issn": "1474-1741", "issn-l": "1474-1733"}, "abstract": "During severe inflammatory and infectious diseases, various mediators modulate the equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review describes the interactive roles of the renin-angiotensin system, the complement system, and the closely linked kallikrein-kinin and contact systems in cell biological functions such as vascular tone and leakage, inflammation, chemotaxis, thrombosis and cell proliferation. Specific attention is given to the role of these systems in systemic inflammation in the vasculature and tissues during hereditary angioedema, cardiovascular and renal glomerular disease, vasculitides and COVID-19. Moreover, we discuss the therapeutic implications of these complex interactions, given that modulation of one system may affect the other systems, with beneficial or deleterious consequences.", "doi": "10.1038/s41577-021-00634-8", "pmid": "34759348", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41577-021-00634-8"}, {"db": "pmc", "key": "PMC8579187"}], "notes": [], "created": "2021-11-26T15:21:35.598Z", "modified": "2021-11-26T15:21:35.698Z"}, {"entity": "publication", "iuid": "64996e79702540a8a8c5a5ec12612391", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/64996e79702540a8a8c5a5ec12612391.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/64996e79702540a8a8c5a5ec12612391"}}, "title": "Prevalence of Gastrointestinal Symptoms in Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Results of the Prospective Controlled Multinational GI-COVID-19 Study.", "authors": [{"family": "Marasco", "given": "Giovanni", "initials": "G"}, {"family": "Cremon", "given": "Cesare", "initials": "C"}, {"family": "Barbaro", "given": "Maria Raffaella", "initials": "MR"}, {"family": "Salvi", "given": "Daniele", "initials": "D"}, {"family": "Cacciari", "given": "Giulia", "initials": "G"}, {"family": "Kagramanova", "given": "Anna", "initials": "A"}, {"family": "Bordin", "given": "Dmitry", "initials": "D"}, {"family": "Drug", "given": "Vasile", "initials": "V"}, {"family": "Miftode", "given": "Edgidia", "initials": "E"}, {"family": "Fusaroli", "given": "Pietro", "initials": "P"}, {"family": "Mohamed", "given": "Salem Youssef", "initials": "SY"}, {"family": "Ricci", "given": "Chiara", "initials": "C"}, {"family": "Bellini", "given": "Massimo", "initials": "M"}, {"family": "Rahman", "given": "M Masudur", "initials": "MM"}, {"family": "Melcarne", "given": "Luigi", "initials": "L"}, {"family": "Santos", "given": "Javier", "initials": "J"}, {"family": "Lobo", "given": "Beatriz", "initials": "B"}, {"family": "Bor", "given": "Serhat", "initials": "S"}, {"family": "Yapali", "given": "Suna", "initials": "S"}, {"family": "Akyol", "given": "Deniz", "initials": "D"}, {"family": "Sapmaz", "given": "Ferdane Pirincci", "initials": "FP"}, {"family": "Urun", "given": "Yonca Yilmaz", "initials": "YY"}, {"family": "Eskazan", "given": "Tugce", "initials": "T"}, {"family": "Celebi", "given": "Altay", "initials": "A"}, {"family": "Kacmaz", "given": "Huseyin", "initials": "H"}, {"family": "Ebik", "given": "Berat", "initials": "B"}, {"family": "Binicier", "given": "Hatice Cilem", "initials": "HC"}, {"family": "Bugdayci", "given": "Mehmet Sait", "initials": "MS"}, {"family": "Ya\u011fc\u0131", "given": "Munkhtsetseg Banzragch", "initials": "MB"}, {"family": "Pullukcu", "given": "Husnu", "initials": "H"}, {"family": "Kaya", "given": "Berrin Yal\u0131nbas", "initials": "BY"}, {"family": "Tureyen", "given": "Ali", "initials": "A"}, {"family": "Hatemi", "given": "\u0130brahim", "initials": "\u0130"}, {"family": "Koc", "given": "Elif Sitre", "initials": "ES"}, {"family": "Sirin", "given": "Goktug", "initials": "G"}, {"family": "Cal\u0131skan", "given": "Ali Riza", "initials": "AR"}, {"family": "Bengi", "given": "Goksel", "initials": "G"}, {"family": "Al\u0131s", "given": "Esra Ergun", "initials": "EE"}, {"family": "Lukic", "given": "Snezana", "initials": "S"}, {"family": "Trajkovska", "given": "Meri", "initials": "M"}, {"family": "Hod", "given": "Keren", "initials": "K"}, {"family": "Dumitrascu", "given": "Dan", "initials": "D"}, {"family": "Pietrangelo", "given": "Antonello", "initials": "A"}, {"family": "Corradini", "given": "Elena", "initials": "E"}, {"family": "Simren", "given": "Magnus", "initials": "M"}, {"family": "Sjolund", "given": "Jessica", "initials": "J"}, {"family": "Tornkvist", "given": "Navkiran", "initials": "N"}, {"family": "Ghoshal", "given": "Uday C", "initials": "UC"}, {"family": "Kolokolnikova", "given": "Olga", "initials": "O"}, {"family": "Colecchia", "given": "Antonio", "initials": "A"}, {"family": "Serra", "given": "Jordi", "initials": "J"}, {"family": "Maconi", "given": "Giovanni", "initials": "G"}, {"family": "De Giorgio", "given": "Roberto", "initials": "R"}, {"family": "Danese", "given": "Silvio", "initials": "S"}, {"family": "Portincasa", "given": "Pietro", "initials": "P"}, {"family": "Di Stefano", "given": "Michele", "initials": "M"}, {"family": "Maggio", "given": "Marcello", "initials": "M"}, {"family": "Philippou", "given": "Elena", "initials": "E"}, {"family": "Lee", "given": "Yeong Yeh", "initials": "YY"}, {"family": "Venturi", "given": "Alessandro", "initials": "A"}, {"family": "Borghi", "given": "Claudio", "initials": "C"}, {"family": "Zoli", "given": "Marco", "initials": "M"}, {"family": "Gionchetti", "given": "Paolo", "initials": "P"}, {"family": "Viale", "given": "Pierluigi", "initials": "P"}, {"family": "Stanghellini", "given": "Vincenzo", "initials": "V"}, {"family": "Barbara", "given": "Giovanni", "initials": "G"}, {"family": "and the GI-COVID19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-09", "journal": {"title": "Am J Gastroenterol", "issn": "1572-0241", "issn-l": null}, "abstract": "Gastrointestinal (GI) symptoms in coronavirus-19 disease (COVID-19) have been reported with great variability and without standardization. In hospitalized patients, we aimed to evaluate the prevalence of GI symptoms, factors associated with their occurrence, and variation at 1 month.\n\nThe GI-COVID-19 is a prospective, multicenter, controlled study. Patients with and without COVID-19 diagnosis were recruited at hospital admission and asked for GI symptoms at admission and after 1 month, using the validated Gastrointestinal Symptom Rating Scale questionnaire.\n\nThe study included 2036 hospitalized patients. A total of 871 patients (575 COVID+ and 296 COVID-) were included for the primary analysis. GI symptoms occurred more frequently in patients with COVID-19 (59.7%; 343/575 patients) than in the control group (43.2%; 128/296 patients) (P < 0.001). Patients with COVID-19 complained of higher presence or intensity of nausea, diarrhea, loose stools, and urgency as compared with controls. At a 1-month follow-up, a reduction in the presence or intensity of GI symptoms was found in COVID-19 patients with GI symptoms at hospital admission. Nausea remained increased over controls. Factors significantly associated with nausea persistence in COVID-19 were female sex, high body mass index, the presence of dyspnea, and increased C-reactive protein levels.\n\nThe prevalence of GI symptoms in hospitalized patients with COVID-19 is higher than previously reported. Systemic and respiratory symptoms are often associated with GI complaints. Nausea may persist after the resolution of COVID-19 infection.", "doi": "10.14309/ajg.0000000000001541", "pmid": "34751672", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00000434-990000000-00142"}, {"db": "ClinicalTrials.gov", "key": "NCT04691895"}], "notes": [], "created": "2021-11-26T15:24:24.070Z", "modified": "2021-11-26T15:24:24.106Z"}, {"entity": "publication", "iuid": "2b4e6205c4f342c4805d41dd1d723a40", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b4e6205c4f342c4805d41dd1d723a40.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b4e6205c4f342c4805d41dd1d723a40"}}, "title": "Length of hospital stay and risk of intensive care admission and in-hospital death among COVID-19 patients in Norway: a register-based cohort study comparing patients fully vaccinated with an mRNA vaccine to unvaccinated patients", "authors": [{"family": "Whittaker", "given": "Robert", "initials": "R"}, {"family": "Br\u00e5then Kristofferson", "given": "Anja", "initials": "A"}, {"family": "Valcarcel Salamanca", "given": "Beatriz", "initials": "B"}, {"family": "Sepp\u00e4l\u00e4", "given": "Elina", "initials": "E"}, {"family": "Golestani", "given": "Karan", "initials": "K"}, {"family": "Kv\u00e5le", "given": "Reidar", "initials": "R"}, {"family": "Watle", "given": "Sara Viksmoen", "initials": "SV"}, {"family": "Buanes", "given": "Eirik Alnes", "initials": "EA"}], "type": "posted-content", "published": "2021-11-09", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.11.05.21265958", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:44:50.667Z", "modified": "2022-01-04T15:44:50.668Z"}, {"entity": "publication", "iuid": "93e4da7e9f8943779eb12a1d7d20110e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/93e4da7e9f8943779eb12a1d7d20110e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/93e4da7e9f8943779eb12a1d7d20110e"}}, "title": "COVID-19: What have we learned? What are the public health challenges?", "authors": [{"family": "Zeegers Paget", "given": "Dineke", "initials": "D"}, {"family": "Allebeck", "given": "Peter", "initials": "P", "orcid": "0000-0002-2778-6467", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de9f0e1c3e4d402b93e61ad1c5a771fb.json"}}, {"family": "Nagyova", "given": "Iveta", "initials": "I"}], "type": "journal-article", "published": "2021-11-09", "journal": {"title": "Eur J Public Health", "issn": "1101-1262", "volume": "31", "issue": "Supplement_4", "pages": "iv1-iv2", "issn-l": null}, "abstract": null, "doi": "10.1093/eurpub/ckab150", "pmid": "34751364", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8576293"}, {"db": "pii", "key": "6423460"}], "notes": [], "created": "2021-11-26T15:24:39.334Z", "modified": "2023-06-19T07:31:51.619Z"}, {"entity": "publication", "iuid": "acb1627ba8ce46d6923061af7507618b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/acb1627ba8ce46d6923061af7507618b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/acb1627ba8ce46d6923061af7507618b"}}, "title": "Advancing African Medicines Agency through Global Health Diplomacy for an Equitable Pan-African Universal Health Coverage: A Scoping Review.", "authors": [{"family": "Chattu", "given": "Vijay Kumar", "initials": "VK", "orcid": "0000-0001-9840-8335", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cebeeb53463e436e9ce1ffc57ec4a9b4.json"}}, {"family": "Dave", "given": "Vishal B", "initials": "VB", "orcid": "0000-0001-8099-1569", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0606a7312b9843c6ac11ba4e7440adc9.json"}}, {"family": "Reddy", "given": "K Srikanth", "initials": "KS"}, {"family": "Singh", "given": "Bawa", "initials": "B"}, {"family": "Sahiledengle", "given": "Biniyam", "initials": "B", "orcid": "0000-0002-1114-4849", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c434b82648f4f4c96d13e82c4a61ae1.json"}}, {"family": "Heyi", "given": "Demisu Zenbaba", "initials": "DZ"}, {"family": "Nattey", "given": "Cornelius", "initials": "C"}, {"family": "Atlaw", "given": "Daniel", "initials": "D", "orcid": "0000-0002-2968-4958", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f44d2cf7abb4db4affc9bad0e273cc7.json"}}, {"family": "Jackson", "given": "Kioko", "initials": "K"}, {"family": "El-Khatib", "given": "Ziad", "initials": "Z", "orcid": "0000-0003-0756-7280", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31747e0476314de9bf53d8c8f3d1d147.json"}}, {"family": "Eltom", "given": "Akram Ali", "initials": "AA"}], "type": "journal article", "published": "2021-11-09", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "22", "pages": null}, "abstract": "The African continent is home to 15% of the world's population and suffers from a disease burden of more than 25% globally. In this COVID-19 era, the high burden and mortality are further worsened due to inequities, inequalities such as inadequate health systems, scarce financial and human resources, as well as unavailability of inexpensive medicines of good quality, safety, and efficacy. The Universal Health Coverage ensures that people have access to high-quality essential health services, secure, reliable, and affordable essential medicines and vaccines, as well as financial security. This paper aimed at addressing the critical need for a continental African Medicines Agency (AMA) in addressing the inequities and the role of global health diplomacy in building consensus to support the ratification of the Treaty of AMA. A literature review was done in Scopus, Web of Science, MEDLINE/PubMed, and Google Scholar search engine to identify the critical literature in the context of study objectives. All the articles published after 2015 till 2021 in the context of AMA were included. African Health Strategy 2016-2030 highlighted the importance of an African regulatory mechanism for medicines and medical products. Through global health diplomacy (GHD), the African Union and its partners can negotiate and cooperate in providing infrastructural, administrative, and regulatory support for establishing the AMA. The paper emphasizes the South-South cooperation and highlights the contributions of India and China in the supply of medicines and vaccines to Africa. A strong AMA created through GHD can be a vital instrument in utilizing Trade-Related Aspects of Intellectual Property Rights (TRIPS) flexibilities extension and an ideal partner for European and other regional regulatory authorities seeking to stem the tide of counterfeit, sub-standard, or fake products.", "doi": "10.3390/ijerph182211758", "pmid": "34831511", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph182211758"}, {"db": "pmc", "key": "PMC8621302"}], "notes": [], "created": "2021-12-18T18:16:31.169Z", "modified": "2021-12-18T18:16:59.133Z"}, {"entity": "publication", "iuid": "210b5b5071e9404daef80cc8c61a3440", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/210b5b5071e9404daef80cc8c61a3440.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/210b5b5071e9404daef80cc8c61a3440"}}, "title": "Rapid and sensitive detection of SARS-CoV-2 infection using quantitative peptide enrichment LC-MS analysis.", "authors": [{"family": "Hober", "given": "Andreas", "initials": "A", "orcid": "0000-0001-8947-2562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20274f9e591044c1936d134df8a1950d.json"}}, {"family": "Tran-Minh", "given": "Khue Hua", "initials": "KH"}, {"family": "Foley", "given": "Dominic", "initials": "D"}, {"family": "McDonald", "given": "Thomas", "initials": "T"}, {"family": "Vissers", "given": "Johannes Pc", "initials": "JP"}, {"family": "Pattison", "given": "Rebecca", "initials": "R"}, {"family": "Ferries", "given": "Samantha", "initials": "S"}, {"family": "Hermansson", "given": "Sigurd", "initials": "S"}, {"family": "Betner", "given": "Ingvar", "initials": "I"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M"}, {"family": "Razavi", "given": "Morteza", "initials": "M"}, {"family": "Yip", "given": "Richard", "initials": "R"}, {"family": "Pope", "given": "Matthew E", "initials": "ME"}, {"family": "Pearson", "given": "Terry W", "initials": "TW"}, {"family": "Andersson", "given": "Leigh N", "initials": "LN"}, {"family": "Bartlett", "given": "Amy", "initials": "A"}, {"family": "Calton", "given": "Lisa", "initials": "L"}, {"family": "Alm", "given": "Jessica J", "initials": "JJ"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Edfors", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-0017-7987", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1908b42d06b74ee99706fb235d4bda90.json"}}], "type": "journal article", "published": "2021-11-08", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "10", "issn-l": null}, "abstract": "Reliable, robust, large-scale molecular testing for SARS-CoV-2 is essential for monitoring the ongoing Covid-19 pandemic. We have developed a scalable analytical approach to detect viral proteins based on peptide immunoaffinity enrichment combined with liquid chromatography - mass spectrometry (LC-MS). This is a multiplexed strategy, based on targeted proteomics analysis and read-out by LC-MS, capable of precisely quantifying and confirming the presence of SARS-CoV-2 in PBS swab media from combined throat/nasopharynx/saliva samples.<br />The results reveal that the levels of SARS-CoV-2 measured by LC-MS correlate well with their corresponding RT-PCR readout (r=0.79). The analytical workflow shows similar turnaround times as regular RT-PCR instrumentation with a quantitative readout of viral proteins corresponding to cycle thresholds (Ct) equivalents ranging from 21 to 34. Using RT-PCR as a reference, we demonstrate that the LC-MS-based method has 100% negative percent agreement (estimated specificity) and 95% positive percent agreement (estimated sensitivity) when analyzing clinical samples collected from asymptomatic individuals with a Ct within the limit of detection of the mass spectrometer (Ct \u226430). These results suggest that a scalable analytical method based on LC-MS has a place in future pandemic preparedness centers to complement current virus detection technologies.", "doi": "10.7554/eLife.70843", "pmid": "34747696", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "70843"}, {"db": "URL", "key": "http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD026366", "description": "PXD026366"}, {"db": "URL", "key": "https://panoramaweb.org/sars-cov-2_siscapa.url", "description": "https://panoramaweb.org/sars-cov-2_siscapa.url"}], "notes": [], "created": "2021-11-26T15:26:16.157Z", "modified": "2021-11-26T15:29:02.059Z"}, {"entity": "publication", "iuid": "07d46c6a5c20498da11b302b3193ee2c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07d46c6a5c20498da11b302b3193ee2c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07d46c6a5c20498da11b302b3193ee2c"}}, "title": "Poor outcome of patients with COVID-19 after CAR T-cell therapy for B-cell malignancies: results of a multicenter study on behalf of the European Society for Blood and Marrow Transplantation (EBMT) Infectious Diseases Working Party and the European Hematology Association (EHA) Lymphoma Group.", "authors": [{"family": "Spanjaart", "given": "Anne Mea", "initials": "AM"}, {"family": "Ljungman", "given": "Per", "initials": "P", "orcid": "0000-0002-8281-3245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4546eb504184683ab712eee858ea9cb.json"}}, {"family": "de La Camara", "given": "Rafael", "initials": "R", "orcid": "0000-0002-8189-5779", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/868bc0284ac640a1bf215e7d7cc86da3.json"}}, {"family": "Tridello", "given": "Gloria", "initials": "G"}, {"family": "Ortiz-Maldonado", "given": "Valent\u00edn", "initials": "V"}, {"family": "Urbano-Ispizua", "given": "Alvaro", "initials": "A"}, {"family": "Barba", "given": "Pere", "initials": "P", "orcid": "0000-0003-1038-5197", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e74c0f29540e4f59aa53f83fec63148f.json"}}, {"family": "Kwon", "given": "Mi", "initials": "M", "orcid": "0000-0002-3855-7774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04365251372d4a07bc1f72e2aaa487d1.json"}}, {"family": "Caballero", "given": "Dolores", "initials": "D"}, {"family": "Sesques", "given": "Pierre", "initials": "P"}, {"family": "Bachy", "given": "Emmanuel", "initials": "E"}, {"family": "Di Blasi", "given": "Roberta", "initials": "R"}, {"family": "Thieblemont", "given": "Catherine", "initials": "C"}, {"family": "Calkoen", "given": "Friso", "initials": "F", "orcid": "0000-0001-9059-0929", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3922445905394bcc810e480b12115a2c.json"}}, {"family": "Mutsaers", "given": "Pim", "initials": "P", "orcid": "0000-0002-3924-8578", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/abf9518b9408436ea710a959f84412af.json"}}, {"family": "Maertens", "given": "Johan", "initials": "J", "orcid": "0000-0003-4257-5980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4701b45871ba4030a2c57c01edcbf6e0.json"}}, {"family": "Giannoni", "given": "Livia", "initials": "L"}, {"family": "Nicholson", "given": "Emma", "initials": "E"}, {"family": "Collin", "given": "Matthew", "initials": "M", "orcid": "0000-0001-6585-9586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28e509d4da164f1d95963e649a3a6d78.json"}}, {"family": "Vaz", "given": "Carlos Pinho", "initials": "CP"}, {"family": "Metafuni", "given": "Elisabetta", "initials": "E"}, {"family": "Martinez-Lopez", "given": "Joaquin", "initials": "J"}, {"family": "Dignan", "given": "Fiona L", "initials": "FL"}, {"family": "Ribera", "given": "Josep-Maria", "initials": "JM"}, {"family": "Nagler", "given": "Arnon", "initials": "A"}, {"family": "Folber", "given": "Frantisek", "initials": "F"}, {"family": "Sanderson", "given": "Robin", "initials": "R"}, {"family": "Bloor", "given": "Adrian", "initials": "A", "orcid": "0000-0003-4550-220X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48157ff9b02f48b1878d9fea89853d4c.json"}}, {"family": "Ciceri", "given": "Fabio", "initials": "F"}, {"family": "Knelange", "given": "Nina", "initials": "N"}, {"family": "Ayuk", "given": "Francis", "initials": "F"}, {"family": "Kroger", "given": "Nicolaus", "initials": "N"}, {"family": "Kersten", "given": "Marie Jos\u00e9", "initials": "MJ"}, {"family": "Mielke", "given": "Stephan", "initials": "S", "orcid": "0000-0003-0167-6021", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b98a5979f3d4471bbbed5f392c31d1ce.json"}}], "type": "journal article", "published": "2021-11-08", "journal": {"title": "Leukemia", "issn": "1476-5551", "issn-l": null}, "abstract": null, "doi": "10.1038/s41375-021-01466-0", "pmid": "34750508", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41375-021-01466-0"}, {"db": "pmc", "key": "PMC8573311"}], "notes": [], "created": "2021-11-26T15:25:32.981Z", "modified": "2021-11-26T15:25:33.293Z"}, {"entity": "publication", "iuid": "2414e9421be64e729b4ecf0ff54aa539", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2414e9421be64e729b4ecf0ff54aa539.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2414e9421be64e729b4ecf0ff54aa539"}}, "title": "How an outbreak became a pandemic: a chronological analysis of crucial junctures and international obligations in the early months of the COVID-19 pandemic.", "authors": [{"family": "Singh", "given": "Sudhvir", "initials": "S"}, {"family": "McNab", "given": "Christine", "initials": "C"}, {"family": "Olson", "given": "Rose McKeon", "initials": "RM"}, {"family": "Bristol", "given": "Nellie", "initials": "N"}, {"family": "Nolan", "given": "Cody", "initials": "C"}, {"family": "Bergstr\u00f8m", "given": "Elin", "initials": "E"}, {"family": "Bartos", "given": "Michael", "initials": "M"}, {"family": "Mabuchi", "given": "Shunsuke", "initials": "S"}, {"family": "Panjabi", "given": "Raj", "initials": "R"}, {"family": "Karan", "given": "Abraar", "initials": "A"}, {"family": "Abdalla", "given": "Salma M", "initials": "SM"}, {"family": "Bonk", "given": "Mathias", "initials": "M"}, {"family": "Jamieson", "given": "Margaret", "initials": "M"}, {"family": "Werner", "given": "George K", "initials": "GK"}, {"family": "Nordstr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Legido-Quigley", "given": "Helena", "initials": "H"}, {"family": "Phelan", "given": "Alexandra", "initials": "A"}], "type": "journal article", "published": "2021-11-08", "journal": {"title": "Lancet", "issn": "1474-547X", "issn-l": "0140-6736"}, "abstract": "Understanding the spread of SARS-CoV-2, how and when evidence emerged, and the timing of local, national, regional, and global responses is essential to establish how an outbreak became a pandemic and to prepare for future health threats. With that aim, the Independent Panel for Pandemic Preparedness and Response has developed a chronology of events, actions, and recommendations, from December, 2019, when the first cases of COVID-19 were identified in China, to the end of March, 2020, by which time the outbreak had spread extensively worldwide and had been characterised as a pandemic. Datapoints are based on two literature reviews, WHO documents and correspondence, submissions to the Panel, and an expert verification process. The retrospective analysis of the chronology shows a dedicated initial response by WHO and some national governments, but also aspects of the response that could have been quicker, including outbreak notifications under the International Health Regulations (IHR), presumption and confirmation of human-to-human transmission of SARS-CoV-2, declaration of a Public Health Emergency of International Concern, and, most importantly, the public health response of many national governments. The chronology also shows that some countries, largely those with previous experience with similar outbreaks, reacted quickly, even ahead of WHO alerts, and were more successful in initially containing the virus. Mapping actions against IHR obligations, the chronology shows where efficiency and accountability could be improved at local, national, and international levels to more quickly alert and contain health threats in the future. In particular, these improvements include necessary reforms to international law and governance for pandemic preparedness and response, including the IHR and a potential framework convention on pandemic preparedness and response.", "doi": "10.1016/S0140-6736(21)01897-3", "pmid": "34762857", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)01897-3"}, {"db": "pmc", "key": "PMC8575464"}], "notes": [], "created": "2021-11-26T15:16:22.583Z", "modified": "2021-11-26T15:16:48.040Z"}, {"entity": "publication", "iuid": "26a045fa28384ae5abc4f75b80218a65", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26a045fa28384ae5abc4f75b80218a65.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26a045fa28384ae5abc4f75b80218a65"}}, "title": "COVID-19 and CAR-T cells: current challenges and future directions-a report from the EPICOVIDEHA survey by EHA-IDWP.", "authors": [{"family": "Busca", "given": "Alessandro", "initials": "A"}, {"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J", "orcid": "0000-0002-6766-8297", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dea501020d2042ad83d1b024987792f4.json"}}, {"family": "Corradini", "given": "Paolo", "initials": "P", "orcid": "0000-0002-9186-1353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d0e56ba864949b68f35a952b7d18036.json"}}, {"family": "Marchesi", "given": "Francesco", "initials": "F"}, {"family": "Cabirta", "given": "Alba", "initials": "A", "orcid": "0000-0001-7198-8894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ca8361c64eb4563a0f090faaf569e8a.json"}}, {"family": "Di Blasi", "given": "Roberta", "initials": "R", "orcid": "0000-0001-9001-573X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b0e256f42ad4d25aef901a2c2df7eab.json"}}, {"family": "Dulery", "given": "Remy", "initials": "R", "orcid": "0000-0002-5024-1713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e911a2d994434edbb736f77b7ccfcd72.json"}}, {"family": "Lamure", "given": "Sylvain", "initials": "S", "orcid": "0000-0001-5980-305X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0dc734a9a9e4016b2a1699809823fe2.json"}}, {"family": "Farina", "given": "Francesca", "initials": "F"}, {"family": "Weinbergerov\u00e1", "given": "Barbora", "initials": "B", "orcid": "0000-0001-6460-2471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7ef50b8f8dc457ab2badd8481b3fa86.json"}}, {"family": "Batini\u0107", "given": "Josip", "initials": "J"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Lopez-Garcia", "given": "Alberto", "initials": "A", "orcid": "0000-0002-5354-5261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c785356a67e4cbb9835fe9ce04a6153.json"}}, {"family": "Drgona", "given": "Lubos", "initials": "L", "orcid": "0000-0002-5089-3201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/746b17dbdf2a4b178e6a11454778c725.json"}}, {"family": "Espigado", "given": "Ildefonso", "initials": "I", "orcid": "0000-0002-4043-6613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40c943f7cd0e40998a4a1ae519a39e48.json"}}, {"family": "Falces-Romero", "given": "Iker", "initials": "I"}, {"family": "Garcia-Sanz", "given": "Ramon", "initials": "R", "orcid": "0000-0003-4120-2787", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8823f2241b74c59bac5fd3915041b1a.json"}}, {"family": "Garcia-Vidal", "given": "Carolina", "initials": "C", "orcid": "0000-0002-8915-0683", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d07f1141779e4aef88a4b126526d241e.json"}}, {"family": "Guidetti", "given": "Anna", "initials": "A"}, {"family": "Khanna", "given": "Nina", "initials": "N"}, {"family": "Kulesekararaj", "given": "Austin", "initials": "A", "orcid": "0000-0003-3180-3570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd4719161efc4d939fe6f4832430a1bc.json"}}, {"family": "Maertens", "given": "Johan", "initials": "J", "orcid": "0000-0003-4257-5980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4701b45871ba4030a2c57c01edcbf6e0.json"}}, {"family": "Hoenigl", "given": "Martin", "initials": "M", "orcid": "0000-0002-1653-2824", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f06a81d02454972bb9b64fea7c14dd4.json"}}, {"family": "Klimko", "given": "Nikolai", "initials": "N", "orcid": "0000-0001-6095-7531", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/da32e1ffe46c49f5a891df4e452b5ce7.json"}}, {"family": "Koehler", "given": "Philipp", "initials": "P"}, {"family": "Pagliuca", "given": "Antonio", "initials": "A"}, {"family": "Passamonti", "given": "Francesco", "initials": "F"}, {"family": "Cornely", "given": "Oliver", "initials": "O", "orcid": "0000-0001-9599-3137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3c62d8346924e69b6c99e4007c3831c.json"}}, {"family": "Pagano", "given": "Livio", "initials": "L", "orcid": "0000-0001-8287-928X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbf92a9779614910aeafcc6c21d880e2.json"}}], "type": "journal article", "published": "2021-11-08", "journal": {"title": "Blood Adv", "issn": "2473-9537", "issn-l": null}, "abstract": "Patients receiving chimeric antigen receptor T cells (CAR-T cells) therapy may be particularly susceptible to coronavirus disease 2019 (COVID-19) because of several factors including the immunosuppression associated to the underlying disease and delayed cytopenias. Regrettably, data on outcomes of CAR-T recipients with COVID-19 are extremely scarce. The aim of this study was to investigate the characteristics and outcomes of COVID-19 in patients treated with CAR-T therapy. The European Hematology Association - Scientific Working Group Infection in Hematology endorsed a survey to collect and analyze data from patients developing COVID-19 after CAR-T therapy. Overall, 459 patients treated with CAR-T cells were reported from 18 European centers. The prevalence of COVID-19 cases was 4.8%. Median time from CAR-T therapy and COVID-19 diagnosis was 169 days. Severe infection occurred in 66.7% of patients and 43.3% of the subjects required admission to ICU. The COVID-19 mortality was 33%. In multivariable analysis, the disease status at the time of COVID-19 trended marginally towards adverse outcome (P=0.075). In conclusion, we documented a high fatality rate for CAR-T patients with COVID-19, supporting the need to design successful interventions to mitigate the risk of infection in this vulnerable group of patients.", "doi": "10.1182/bloodadvances.2021005616", "pmid": "34749396", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "477883"}, {"db": "pmc", "key": "PMC8575532"}], "notes": [], "created": "2021-11-26T15:25:48.657Z", "modified": "2021-11-26T15:25:48.910Z"}, {"entity": "publication", "iuid": "c43d6c2225434e9f9fa38e7116ea1531", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c43d6c2225434e9f9fa38e7116ea1531.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c43d6c2225434e9f9fa38e7116ea1531"}}, "title": "Avian influenza, a new threat to public health in Europe?", "authors": [{"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Baldinelli", "given": "Francesca", "initials": "F"}, {"family": "Fusaro", "given": "Alice", "initials": "A"}, {"family": "Terregino", "given": "Calogero", "initials": "C"}], "type": "journal article", "published": "2021-11-08", "journal": {"title": "Clin Microbiol Infect", "issn": "1469-0691", "issn-l": null}, "abstract": "In our comment we outline the unprecedented situation on avian influenza virus in Europe and globally. We discuss the rapid emergence, diversification, global spread and impact of circulating avian influenza viruses of clade 2.3.4.4b in the light of increasing number of human cases globally and transmission events to other mammal species in Europe. Low levels of circulation of seasonal influenza due to the ongoing SARS-CoV-2 pandemic might hamper the early identification of human avian influenza cases due to lack of awareness or testing. This comment aims to raise awareness among clinicians, microbiologists and animal, public as well as occupational health experts about the ongoing threat of avian influenza viruses to human health also in Europe.", "doi": "10.1016/j.cmi.2021.11.005", "pmid": "34763057", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(21)00632-7"}], "notes": [], "created": "2021-11-26T15:15:47.163Z", "modified": "2021-11-26T15:15:57.578Z"}, {"entity": "publication", "iuid": "83ac762900b94d5e82d42f3f5d2a59e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/83ac762900b94d5e82d42f3f5d2a59e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/83ac762900b94d5e82d42f3f5d2a59e7"}}, "title": "Risk of hospitalization and risk of death for health care workers with COVID-19 in nine European countries, January 2020-January 2021.", "authors": [{"family": "Ferland", "given": "Lisa", "initials": "L"}, {"family": "Carvalho", "given": "Carlos", "initials": "C"}, {"family": "Dias", "given": "Joana Gomes", "initials": "JG"}, {"family": "Lamb", "given": "Favelle", "initials": "F"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Suetens", "given": "Carl", "initials": "C"}, {"family": "Beaut\u00e9", "given": "Julien", "initials": "J"}, {"family": "Kinross", "given": "Pete", "initials": "P"}, {"family": "Plachouras", "given": "Diamantis", "initials": "D"}, {"family": "Hannila-Handelberg", "given": "Tuula", "initials": "T"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "van Gageldonk-Lafeber", "given": "Rianne", "initials": "R"}, {"family": "Teirlinck", "given": "Anne C", "initials": "AC"}, {"family": "Mossong", "given": "Jo\u00ebl", "initials": "J"}, {"family": "Vergison", "given": "Anne", "initials": "A"}, {"family": "Melillo", "given": "Jackie", "initials": "J"}, {"family": "Melillo", "given": "Tanya", "initials": "T"}, {"family": "Mook", "given": "Piers", "initials": "P"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "Coutinho Rehse", "given": "Ana Paula", "initials": "AP"}, {"family": "Monnet", "given": "Dominique L", "initials": "DL"}], "type": "journal article", "published": "2021-11-06", "journal": {"title": "J Hosp Infect", "issn": "1532-2939", "issn-l": null}, "abstract": "We present and compare COVID-19 attack rates for infection, hospitalization, admission to intensive care unit (ICU), and death, in health care workers (HCW) and non-HCWs in nine European countries from 31 January 2020 to 13 January 2021. Adjusted attack rate ratios in HCWs (compared to non-HCWs) were 3.0 [95% confidence interval: 2.2-4.0] for infection, 1.8 [1.2-2.7] for hospitalization, 1.9 [1.1-3.2] for ICU admission and 0.9 [0.4-2.0] for death. Among hospitalized cases, case-fatality ratio was 1.8% in HCWs and 8.2% in non-HCWs. Differences might be due to better/earlier access to treatment, differential under-ascertainment, and to the healthy worker effect.", "doi": "10.1016/j.jhin.2021.10.015", "pmid": "34752802", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0195-6701(21)00379-0"}], "notes": [], "created": "2021-11-26T15:24:11.932Z", "modified": "2021-11-26T15:24:11.966Z"}, {"entity": "publication", "iuid": "1be19e040a094cac92dc986abf48c657", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1be19e040a094cac92dc986abf48c657.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1be19e040a094cac92dc986abf48c657"}}, "title": "Partner responsiveness moderates the relation between COVID-19-related stressors and changes in mood during the pandemic.", "authors": [{"family": "Soares", "given": "Lorrayne Stephane", "initials": "LS"}, {"family": "Rodrigues", "given": "Aliny Cristina", "initials": "AC"}, {"family": "de Paula", "given": "Jonas Jardim", "initials": "JJ"}, {"family": "Thorell", "given": "Lisa B", "initials": "LB"}, {"family": "de Miranda", "given": "Debora Marques", "initials": "DM"}], "type": "case reports", "published": "2021-11-06", "journal": {"title": "Curr Psychol", "issn": "1046-1310", "issn-l": null, "volume": null, "issue": null, "pages": "1-8"}, "abstract": "The COVID-19 pandemic has created an unusually stressful situation for many people around the world. Due to the restrictions, many have been isolated in their homes, and having a responsive partner may have become even more important. The present study aimed to investigate (1) whether there were any differences in social and work-related stressors and changes in negative mood during the COVID-19 pandemic as a function of marital status, and (2) whether perceived partner responsiveness can attenuate the associations between COVID-19-related stressors and changes in negative mood. The participants were 2,400 Brazilian adults recruited via the Internet, using a virtual sampling strategy. They were assigned to three distinct groups based on their relationship status. The results showed that a relatively large proportion of the sample reported increased levels of negative mood, and that married/cohabitating couples reported low levels of negative change in mood compared to single participants. We also found that partner responsiveness attenuated the association between stress and mental health, but only for people who were dating. Our study contributes new insights by showing that effects on mental health during the COVID-19 pandemic are dependent on relationship type and perceived partner responsiveness.", "doi": "10.1007/s12144-021-02429-5", "pmid": "34776716", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2429"}, {"db": "pmc", "key": "PMC8571670"}], "notes": [], "created": "2021-11-26T14:28:31.819Z", "modified": "2021-11-26T14:29:20.306Z"}, {"entity": "publication", "iuid": "280c373efc0a471f938e926d69a253f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/280c373efc0a471f938e926d69a253f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/280c373efc0a471f938e926d69a253f8"}}, "title": "Heart failure in type 2 diabetes: current perspectives on screening, diagnosis and management.", "authors": [{"family": "Ceriello", "given": "Antonio", "initials": "A", "orcid": "0000-0001-8122-3203", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1409105396004023a189c4ea96e0f410.json"}}, {"family": "Catrinoiu", "given": "Doina", "initials": "D"}, {"family": "Chandramouli", "given": "Chanchal", "initials": "C"}, {"family": "Cosentino", "given": "Francesco", "initials": "F"}, {"family": "Dombrowsky", "given": "Annique Cornelia", "initials": "AC"}, {"family": "Itzhak", "given": "Baruch", "initials": "B"}, {"family": "Lalic", "given": "Nebojsa Mali\u0107", "initials": "NM"}, {"family": "Prattichizzo", "given": "Francesco", "initials": "F"}, {"family": "Schnell", "given": "Oliver", "initials": "O"}, {"family": "Seferovi\u0107", "given": "Petar M", "initials": "PM"}, {"family": "Valensi", "given": "Paul", "initials": "P"}, {"family": "Standl", "given": "Eberhard", "initials": "E"}, {"family": "D&CVD EASD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-06", "journal": {"title": "Cardiovasc Diabetol", "issn": "1475-2840", "volume": "20", "issue": "1", "pages": "218", "issn-l": null}, "abstract": "Type 2 diabetes is one of the most relevant risk factors for heart failure, the prevalence of which is increasing worldwide. The aim of the review is to highlight the current perspectives of the pathophysiology of heart failure as it pertains to type 2 diabetes. This review summarizes the proposed mechanistic bases, explaining the myocardial damage induced by diabetes-related stressors and other risk factors, i.e., cardiomyopathy in type 2 diabetes. We highlight the complex pathology of individuals with type 2 diabetes, including the relationship with chronic kidney disease, metabolic alterations, and heart failure. We also discuss the current criteria used for heart failure diagnosis and the gold standard screening tools for individuals with type 2 diabetes. Currently approved pharmacological therapies with primary use in type 2 diabetes and heart failure, and the treatment-guiding role of NT-proBNP are also presented. Finally, the influence of the presence of type 2 diabetes as well as heart failure on COVID-19 severity is briefly discussed.", "doi": "10.1186/s12933-021-01408-1", "pmid": "34740359", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12933-021-01408-1"}], "notes": [], "created": "2021-11-08T09:21:26.835Z", "modified": "2021-11-08T09:21:26.892Z"}, {"entity": "publication", "iuid": "a7133775d8e644d393d407b3da392cab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7133775d8e644d393d407b3da392cab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7133775d8e644d393d407b3da392cab"}}, "title": "Objective Assessment of Covid-19 Severity Affecting the Vocal and Respiratory System Using a Wearable, Autonomous Sound Collar.", "authors": [{"family": "Ishac", "given": "D", "initials": "D"}, {"family": "Matta", "given": "S", "initials": "S"}, {"family": "Bin", "given": "S", "initials": "S"}, {"family": "Aziz", "given": "H", "initials": "H"}, {"family": "Karam", "given": "E", "initials": "E"}, {"family": "Abche", "given": "A", "initials": "A"}, {"family": "Nassar", "given": "G", "initials": "G", "orcid": "0000-0002-8413-3307", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37be6a1d90b243f5ab4ca936d4537a2d.json"}}], "type": "journal article", "published": "2021-11-05", "journal": {"title": "Cell Mol Bioeng", "issn": "1865-5025", "pages": "1-20", "issn-l": null}, "abstract": "Since the outbreak began in January 2020, Covid-19 has affected more than 161 million people worldwide and resulted in about 3.3 million deaths. Despite efforts to detect human infection with the virus as early as possible, the confirmatory test still requires the analysis of sputum or blood with estimated results available within approximately 30 minutes; this may potentially be followed by clinical referral if the patient shows signs of aggravated pneumonia. This work aims to implement a soft collar as a sound device dedicated to the objective evaluation of the pathophysiological state resulting from dysphonia of laryngeal origin or respiratory failure of inflammatory origin, in particular caused by Covid-19.\n\nIn this study, we exploit the vibrations of waves generated by the vocal and respiratory system of 30 people. A biocompatible acoustic sensor embedded in a soft collar around the neck collects these waves. The collar is also equipped with thermal sensors and a cross-data analysis module in both the temporal and frequency domains (STFT). The optimal coupling conditions and the electrical and dimensional characteristics of the sensors were defined based on a mathematical approach using a matrix formalism.\n\nThe characteristics of the signals in the time domain combined with the quantities obtained from the STFT offer multidimensional information and a decision support tool for determining a pathophysiological state representative of the symptoms explored. The device, tested on 30 people, was able to differentiate patients with mild symptoms from those who had developed acute signs of respiratory failure on a severity scale of 1 to 10.\n\nWith the health constraints imposed by the effects of Covid-19, the heavy organization to be implemented resulting from the flow of diagnostics, tests and clinical management, it was urgent to develop innovative and safe biomedical technologies. This passive listening technique will contribute to the non-invasive assessment and dynamic observation of lesions. Moreover, it merits further examination to provide support for medical operators to improve clinical management.\n\nThe online version contains supplementary material available at 10.1007/s12195-021-00712-w.", "doi": "10.1007/s12195-021-00712-w", "pmid": "34777597", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "712"}, {"db": "pmc", "key": "PMC8570400"}], "notes": [], "created": "2021-11-26T14:27:31.945Z", "modified": "2021-11-26T14:27:32.026Z"}, {"entity": "publication", "iuid": "2e52c172c947474e89a0f1ab9da80a78", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e52c172c947474e89a0f1ab9da80a78.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e52c172c947474e89a0f1ab9da80a78"}}, "title": "Internet addiction and sleep quality among medical students during the COVID-19 pandemic: A multinational cross-sectional survey.", "authors": [{"family": "Tahir", "given": "Muhammad Junaid", "initials": "MJ"}, {"family": "Malik", "given": "Najma Iqbal", "initials": "NI", "orcid": "0000-0002-3521-1014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c17242b513143b18e3bb8108f009ca4.json"}}, {"family": "Ullah", "given": "Irfan", "initials": "I", "orcid": "0000-0003-1100-101X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8d5a7e15ae6487cbdda0de3b2a531c3.json"}}, {"family": "Khan", "given": "Hamza Rafique", "initials": "HR"}, {"family": "Perveen", "given": "Shahida", "initials": "S"}, {"family": "Ramalho", "given": "Rodrigo", "initials": "R"}, {"family": "Siddiqi", "given": "Ahsun Rizwan", "initials": "AR", "orcid": "0000-0003-4699-6221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a86efce9fcb4b8d8e3563d416b5fe83.json"}}, {"family": "Waheed", "given": "Summaiya", "initials": "S", "orcid": "0000-0003-1199-3039", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c767edcc9e1940ccb289fa8063ba7c98.json"}}, {"family": "Shalaby", "given": "Mahmoud Mohamed Mohamed", "initials": "MMM", "orcid": "0000-0001-7237-4616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51ae61a95e0243438b5603032c6bc49b.json"}}, {"family": "De Berardis", "given": "Domenico", "initials": "D"}, {"family": "Jain", "given": "Samiksha", "initials": "S"}, {"family": "Vetrivendan", "given": "Gautham Lakshmipriya", "initials": "GL"}, {"family": "Chatterjee", "given": "Harshita", "initials": "H"}, {"family": "Gopar Franco", "given": "William Xochitun", "initials": "WX"}, {"family": "Shafiq", "given": "Muhammad Ahsan", "initials": "MA", "orcid": "0000-0002-2255-4544", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb7c68b72c2a424c8dacee6414d5fb07.json"}}, {"family": "Fatima", "given": "Naira Taiba", "initials": "NT"}, {"family": "Abeysekera", "given": "Maria", "initials": "M", "orcid": "0000-0002-3222-5402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47aee02b846743a4aa205920b66b045a.json"}}, {"family": "Sayyeda", "given": "Qudsia", "initials": "Q"}, {"family": "Shamat", "given": "Shamat Fathi", "initials": "SF"}, {"family": "Aiman", "given": "Wajeeha", "initials": "W", "orcid": "0000-0001-8306-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef22926250924ef3af43732b663197e6.json"}}, {"family": "Akhtar", "given": "Qirat", "initials": "Q"}, {"family": "Devi", "given": "Arooj", "initials": "A"}, {"family": "Aftab", "given": "Anam", "initials": "A"}, {"family": "Shoib", "given": "Sheikh", "initials": "S"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-11-05", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "11", "pages": "e0259594", "issn-l": "1932-6203"}, "abstract": "The emergence of the COVID-19 pandemic has affected the lives of many people, including medical students. The present study explored internet addiction and changes in sleep patterns among medical students during the pandemic and assessed the relationship between them.\n\nA cross-sectional study was carried out in seven countries, the Dominican Republic, Egypt, Guyana, India, Mexico, Pakistan, and Sudan, using a convenience sampling technique, an online survey comprising demographic details, information regarding COVID-19, the Pittsburgh Sleep Quality Index (PSQI), and the Internet Addiction Test (IAT).\n\nIn total, 2749 participants completed the questionnaire. Of the total, 67.6% scored above 30 in the IAT, suggesting the presence of an Internet addiction, and 73.5% scored equal and above 5 in the PSQI, suggesting poor sleep quality. Internet addiction was found to be significant predictors of poor sleep quality, causing 13.2% of the variance in poor sleep quality. Participants who reported COVID-19 related symptoms had disturbed sleep and higher internet addiction levels when compared with those who did not. Participants who reported a diagnosis of COVID-19 reported poor sleep quality. Those living with a COVID-19 diagnosed patient reported higher internet addiction and worse sleep quality compared with those who did not have any COVID-19 patients in their surroundings.\n\nThe results of this study suggest that internet addiction and poor sleep quality are two issues that require addressing amongst medical students. Medical training institutions should do their best to minimize their negative impact, particularly during the current COVID-19 pandemic.", "doi": "10.1371/journal.pone.0259594", "pmid": "34739502", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-19421"}, {"db": "pmc", "key": "PMC8570473"}], "notes": [], "created": "2021-11-08T09:20:03.775Z", "modified": "2021-11-26T15:37:15.553Z"}, {"entity": "publication", "iuid": "8f20f3230f124a80863085063aa508b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f20f3230f124a80863085063aa508b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f20f3230f124a80863085063aa508b4"}}, "title": "Gastrointestinal Manifestations and Possible Mechanisms of COVID-19 in Different Periods.", "authors": [{"family": "Zhang", "given": "Mengmeng", "initials": "M"}, {"family": "Chen", "given": "Luni", "initials": "L"}, {"family": "Qian", "given": "Jiaming", "initials": "J", "orcid": "0000-0001-6611-9475", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/97782f236bdb4f5db68af8f464f1634c.json"}}], "type": "journal article", "published": "2021-11-05", "journal": {"title": "J Dig Dis", "issn": "1751-2980", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19), as a new infectious disease, has spread worldwide. COVID-19 mainly impacts respiratory system, but digestive manifestations have been frequently described in COVID-19 cases as well, even as the initial symptoms. And there have been several reports about the different gastrointestinal (GI) manifestations in mild and severe patients or in remission stages. So it is reasonable to consult that GI symptoms have distinct characteristics in different periods of COVID-19. Therefore, this review article will try to summarize the gastrointestinal manifestations and possible mechanisms of COVID-19 in different periods, and explain the significance of gastrointestinal manifestations in systemic inflammatory injury. This article is protected by copyright. All rights reserved.", "doi": "10.1111/1751-2980.13065", "pmid": "34738727", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-11-08T09:19:20.920Z", "modified": "2021-11-26T15:39:49.918Z"}, {"entity": "publication", "iuid": "32ee20e91fb54cbd8899a8b1077d4d67", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/32ee20e91fb54cbd8899a8b1077d4d67.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/32ee20e91fb54cbd8899a8b1077d4d67"}}, "title": "Physical Function, Cognitive Function, and Daily Activities in Patients Hospitalized Due to COVID-19: A Descriptive Cross-Sectional Study in Sweden.", "authors": [{"family": "Larsson", "given": "Alexandra C", "initials": "AC", "orcid": "0000-0001-9100-4071", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8532302825d744c7b29ccefeb16e11e2.json"}}, {"family": "Palstam", "given": "Annie", "initials": "A"}, {"family": "Persson", "given": "Hanna C", "initials": "HC", "orcid": "0000-0001-8633-3292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc8035c749ab4521b549ea820f6b4389.json"}}], "type": "journal article", "published": "2021-11-04", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "21", "issn-l": null}, "abstract": "An estimated 14-20% of people infected with COVID-19 require medical care. The aim of the present study was to evaluate physical function, cognitive function, and daily activities in patients hospitalized due to COVID-19, and to investigate differences depending on age and admission to the intensive care unit (ICU). This prospective descriptive cross-sectional study included a consecutive sample of 211 patients (mean age 65.1 years, 67.3% men) hospitalized due to COVID-19 in Sweden. Data regarding physical function and daily activities were collected in hospital from July 2020 to February 2021. The average length of hospital stay was 33.8 days, and 48.8% of the patients were admitted to the ICU. Physical function (grip- and lower body strength) was reduced in both groups, and significantly more in the older group, \u226565 years old, compared to the younger. Furthermore, the older group also had significantly less ability to perform activities in daily life, and had significantly reduced cognitive function as compared to the younger age group. In patients treated in the ICU, physical impairments as well as the activity level were significantly more pronounced compared to patients not treated in the ICU. Patients hospitalized due to COVID-19 are physically impaired, have mild cognitive impairments, and have difficulties performing daily activities. The findings in this study indicate the need for out-patient follow-up and rehabilitation for patients hospitalized due to COVID-19, especially in older patients and patients treated in the ICU.", "doi": "10.3390/ijerph182111600", "pmid": "34770113", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182111600"}, {"db": "pmc", "key": "PMC8582899"}], "notes": [], "created": "2021-11-26T15:08:28.992Z", "modified": "2021-11-26T15:08:29.085Z"}, {"entity": "publication", "iuid": "c527b9a6aa9c4e09857d147f3a39a164", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c527b9a6aa9c4e09857d147f3a39a164.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c527b9a6aa9c4e09857d147f3a39a164"}}, "title": "Digital Entry-Level Education in Physiotherapy: a Commentary to Inform Post-COVID-19 Future Directions.", "authors": [{"family": "Rossettini", "given": "Giacomo", "initials": "G", "orcid": "0000-0002-1623-7681", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a762502a2851423abc3f64ebc500eb2f.json"}}, {"family": "Turolla", "given": "Andrea", "initials": "A", "orcid": "0000-0002-1609-8060", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02bc8df4293942a6bb90e78787e347e7.json"}}, {"family": "Gudjonsdottir", "given": "Bjorg", "initials": "B", "orcid": "0000-0003-4566-9333", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/082e09793ae7433796603a7352364699.json"}}, {"family": "Kapreli", "given": "Eleni", "initials": "E", "orcid": "0000-0001-6752-427X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44e98c8f41f042b2834bc757fbefa1ee.json"}}, {"family": "Salchinger", "given": "Beate", "initials": "B", "orcid": "0000-0003-2132-5384", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bad611449f04d4382fec7dfc8f1785e.json"}}, {"family": "Verheyden", "given": "Geert", "initials": "G", "orcid": "0000-0003-3095-8175", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19a2c35a537e4483923467fa8ecef9ab.json"}}, {"family": "Palese", "given": "Alvisa", "initials": "A", "orcid": "0000-0002-3508-844X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea400153bf344f98a5e06367b0442e17.json"}}, {"family": "Dell'Isola", "given": "Andrea", "initials": "A", "orcid": "0000-0002-0319-458X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d8ea417b7c447f8bc4da9f47f9feb39.json"}}, {"family": "de Caro", "given": "John Xerri", "initials": "JX", "orcid": "0000-0003-1198-1660", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aaa4c4a9eeb24a01af410608a82465da.json"}}], "type": "editorial", "published": "2021-11-04", "journal": {"title": "Med Sci Educ", "issn": "2156-8650", "pages": "1-13", "issn-l": null}, "abstract": "Currently, the coronavirus disease 2019 (COVID-19) severely influences physiotherapy education which is based mostly on face-to-face teaching. Thus, educators have been compelled to adapt their pedagogical approaches moving to digital education. In this commentary, we debate on digital education highlighting its effectiveness, the users' perspectives, and its weakness in the context of physiotherapy teaching aimed at informing post-COVID-19 future directions in this educational field. Existing evidence on digital education produced before COVID-19 supports its implementation into entry-level physiotherapy education. However, some challenges (e.g. social inequality and evaluation of students) threaten its applicability in post-COVID-19 era, calling educators to take appropriate actions.", "doi": "10.1007/s40670-021-01439-z", "pmid": "34754600", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "1439"}, {"db": "pmc", "key": "PMC8567978"}], "notes": [], "created": "2021-11-26T15:23:41.362Z", "modified": "2021-11-26T15:23:50.633Z"}, {"entity": "publication", "iuid": "862d1ff1e9f6423da651586d40730006", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/862d1ff1e9f6423da651586d40730006.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/862d1ff1e9f6423da651586d40730006"}}, "title": "Whole-Blood DNA Methylation Analysis Reveals Respiratory Environmental Traits Involved in COVID-19 Severity Following SARS-CoV-2 Infection", "authors": [{"family": "Barturen", "given": "Guillermo", "initials": "G", "orcid": "0000-0003-2103-1028", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a338918e305480497c4e51b5874dd52.json"}}, {"family": "Carnero-Montoro", "given": "Elena", "initials": "E"}, {"family": "Mart\u00ednez-Bueno", "given": "Manuel", "initials": "M"}, {"family": "Rojo-Rello", "given": "Silvia", "initials": "S"}, {"family": "Sobrino", "given": "Beatriz", "initials": "B"}, {"family": "Alc\u00e1ntara-Dom\u00ednguez", "given": "Clara", "initials": "C"}, {"family": "Bernardo", "given": "David", "initials": "D"}, {"family": "Alarc\u00f3n-Riquelme", "given": "Marta E", "initials": "ME"}], "type": "posted-content", "published": "2021-11-03", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.11.03.21260184", "pmid": null, "labels": {"Category: Health": null, "Type: Preprint": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-11-08T09:24:08.423Z", "modified": "2021-11-08T09:24:08.467Z"}, {"entity": "publication", "iuid": "0adda81270ec4cc89f61c155e06af98d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0adda81270ec4cc89f61c155e06af98d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0adda81270ec4cc89f61c155e06af98d"}}, "title": "Telephone-based behavioral activation with mental imagery for depression: A pilot randomized clinical trial in isolated older adults during the Covid-19 pandemic.", "authors": [{"family": "Pellas", "given": "Johnny", "initials": "J", "orcid": "0000-0002-0707-0832", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b194cea3f31a427b99b5dadcc7ab378d.json"}}, {"family": "Renner", "given": "Fritz", "initials": "F"}, {"family": "Ji", "given": "Julie L", "initials": "JL"}, {"family": "Damberg", "given": "Mattias", "initials": "M"}], "type": "journal article", "published": "2021-11-03", "journal": {"title": "Int J Geriatr Psychiatry", "issn": "1099-1166", "issn-l": null}, "abstract": "To shield vulnerable persons, particularly the elderly, during the Covid-19 pandemic governments around the world have advised to use social distancing and self-isolation. Social isolation might put older adults at an increased risk for mental health problems such as depression. There is a need for brief, easy-accessible psychological treatments for depressive symptoms that can be delivered remotely. The aim of this study was to investigate the feasibility, acceptability, and preliminary efficacy of telephone-delivered Behavioral Activation with Mental Imagery (BA-MI) for the treatment of depressive symptoms in individuals 65 years and older living in isolation during the Covid-19 pandemic.\n\nIn this open-label pilot randomized clinical trial, N = 41 individuals aged 65 years or older with clinically significant symptoms of depression were randomly assigned to either a BA-MI treatment condition, or an Attention-Assessment control condition delivered over the telephone over a 4-week period.\n\nDepressive symptoms decreased more in the treatment condition compared to the control condition. At post-treatment, 2 out of 16 participants in the treatment condition met diagnostic criteria for depression compared to 9 out of 13 in the control condition. Most participants in the treatment condition were satisfied with the treatment and few adverse effects were observed.\n\nThis pilot study suggests that behavioral activation with mental imagery delivered over the telephone is feasible, acceptable, and potentially efficacious for the treatment of depressive symptoms in older individuals living in isolation. Replication in larger samples is needed.", "doi": "10.1002/gps.5646", "pmid": "34729823", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T15:41:40.865Z", "modified": "2021-11-26T15:41:40.938Z"}, {"entity": "publication", "iuid": "41c5838635aa470197d9531080584fbb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41c5838635aa470197d9531080584fbb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41c5838635aa470197d9531080584fbb"}}, "title": "Changes in Self-Reported Web-Based Gambling Activity During the COVID-19 Pandemic: Cross-sectional Study.", "authors": [{"family": "Claesdotter-Knutsson", "given": "Emma", "initials": "E", "orcid": "0000-0002-6832-2482", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8738736985b40b3bdf49061f734f62f.json"}}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A", "orcid": "0000-0002-5800-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec14ecdcc0654d8ea864f64ce195752b.json"}}], "type": "journal article", "published": "2021-11-03", "journal": {"title": "JMIR Serious Games", "issn": "2291-9279", "volume": "9", "issue": "4", "pages": "e30747", "issn-l": null}, "abstract": "The COVID\u201119 pandemic has affected not only somatic health with over 3.7 million deaths worldwide, but also has had a huge impact on psychological health, creating what amounts to a mental health crisis. The negative effect of the pandemic on traditional addictions is well described and concerning, and the same has been seen for gambling.\n\nThis study explores self-reported web-based gambling behavior during the COVID\u201119 pandemic in Sweden. We investigated overall changes, but also changes in specific web-based gambling types, and whether they are associated with certain risk factors or lifestyle changes.\n\nOur study is based on an anonymous web-based survey of web panel participants in Sweden (N=1501) designed to study a range of behavioral changes during the COVID\u201119 pandemic. Increases in gambling were analyzed using logistic regression models against sociodemographic data and psychological distress.\n\nThe majority of the respondents who gambled reported no changes in their gambling habits during the COVID\u201119 pandemic. We found significant associations with the problem gambling severity index (PGSI), the Kessler score (indicating psychological distress), employment status, changes in alcohol habits, and self-exclusion when looking at overall changes in gambling activity in the pandemic. In the subgroup that reported an increase in gambling activity, we found an association with both the PGSI and Kessler scores. The PGSI score was also an independent predictor for all specific web-based gambling (horses, sports, poker, and casino) whereas the Kessler score only had a significant impact on changes in casino gambling. In addition, male gender was an independent predictor for gambling on sports and casino gambling.\n\nThe majority of respondents who gambled reported no changes in their gambling activity during the COVID\u201119 pandemic. The group that reported an increase in overall gambling activity during the COVID-19 pandemic represent a group with gambling problems and psychological distress. The group that reported increased sports and casino gambling were often male, and this group seemed to experience more psychological distress.", "doi": "10.2196/30747", "pmid": "34730540", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "v9i4e30747"}, {"db": "pmc", "key": "PMC8568044"}], "notes": [], "created": "2021-11-08T09:15:10.855Z", "modified": "2021-11-26T15:41:19.258Z"}, {"entity": "publication", "iuid": "5bcd844252e14ddfae807c3083021b97", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5bcd844252e14ddfae807c3083021b97.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5bcd844252e14ddfae807c3083021b97"}}, "title": "Changes in Mental Health and Views on Communication and Activities of Public Institutions among Swedes during the COVID-19 Pandemic-A Cross-Sectional Repeated Measures Design.", "authors": [{"family": "Kerstis", "given": "Birgitta", "initials": "B", "orcid": "0000-0003-0242-0343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b50ad01a7fdd43b589b7ec07cf98f220.json"}}, {"family": "Giannotta", "given": "Fabrizia", "initials": "F"}, {"family": "W\u00e5gert", "given": "Petra von Heideken", "initials": "PVH", "orcid": "0000-0001-6292-7010", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4d6dfb26a37419385eb8e257f89d950.json"}}, {"family": "Hellstr\u00f6m", "given": "Charlotta", "initials": "C", "orcid": "0000-0003-1675-4408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a211ac4b50f24a3ca7be0deb42bc3362.json"}}, {"family": "Lindberg", "given": "Daniel", "initials": "D", "orcid": "0000-0002-8541-1727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f40c1556e4545a3a69893d276425af9.json"}}, {"family": "Stier", "given": "Jonas", "initials": "J"}, {"family": "Elv\u00e9n", "given": "Maria", "initials": "M", "orcid": "0000-0001-5356-916X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d90589956db4920b99e166ed4c6dfb2.json"}}], "type": "journal article", "published": "2021-11-03", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "volume": "9", "issue": "11", "issn-l": null}, "abstract": "Although many studies have been conducted on the effects of COVID-19 on individual lives, only a few focus on the changes in mental health and views of public institutions during the pandemic. This study aimed to investigate how mental health, i.e., life satisfaction, worries, and psychological distress, and views on public institutions' communication and activities have changed among Swedes during the COVID-19 pandemic, and whether this was moderated by age and sex. In April-May 2020 (survey 1) and in January-February 2021 (survey 2), 2554 adults and 1904 newly recruited adults, respectively, anonymously completed online surveys. We found that life satisfaction and psychological distress did not change from survey 1 to survey 2. However, the level of worries increased, and the positive views of the public institutions decreased. Moreover, worries and psychological distress increased more in young adults than older adults. Finally, the change in the views of the public institutions was not related to the change in worries. Our results highlight the COVID-19 long-term impacts on individual mental health and call for the need for future research concerning the consequences for the population, especially among young adults. The results also indicate that the views on activities of public authorities decreased over time, especially among men. Given that loss of this trust can have vastly negative effects, for instance, on the vaccine campaign, it is important to monitor this trend, to increase awareness among Swedish authorities. The results also stress for institutions to provide adequate support both during the COVID-19 pandemic and in a future crisis.", "doi": "10.3390/healthcare9111498", "pmid": "34828544", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "healthcare9111498"}, {"db": "pmc", "key": "PMC8625226"}], "notes": [], "created": "2021-12-18T18:17:09.585Z", "modified": "2021-12-18T18:17:15.382Z"}, {"entity": "publication", "iuid": "d6f9488ca04245678ffcb70d7f6bd3e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d6f9488ca04245678ffcb70d7f6bd3e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d6f9488ca04245678ffcb70d7f6bd3e7"}}, "title": "Rolling Circle Amplification in Integrated Microsystems: An Uncut Gem toward Massively Multiplexed Pathogen Diagnostics and Genotyping.", "authors": [{"family": "Soares", "given": "Ruben R G", "initials": "RRG", "orcid": "0000-0001-5958-5232", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2fc2815bc25c4fb78df63294947ee184.json"}}, {"family": "Madaboosi", "given": "Narayanan", "initials": "N"}, {"family": "Nilsson", "given": "Mats", "initials": "M", "orcid": "0000-0001-9985-0387", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/797aac5da3e9472a98af20d637d89784.json"}}], "type": "journal article", "published": "2021-11-02", "journal": {"title": "Acc Chem Res", "issn": "1520-4898", "issn-l": null, "volume": "54", "issue": "21", "pages": "3979-3990"}, "abstract": "The development of robust methods allowing the precise detection of specific nucleic acid sequences is of major societal relevance, paving the way for significant advances in biotechnology and biomedical engineering. These range from a better understanding of human disease at a molecular level, allowing the discovery and development of novel biopharmaceuticals and vaccines, to the improvement of biotechnological processes providing improved food quality and safety, efficient green fuels, and smart textiles. Among these applications, the significance of pathogen diagnostics as the main focus of this Account has become particularly clear during the recent SARS-CoV-2 pandemic. In this context, while RT-PCR is the gold standard method for unambiguous detection of genetic material from pathogens, other isothermal amplification alternatives circumventing rapid heating-cooling cycles up to \u223c95 \u00b0C are appealing to facilitate the translation of the assay into point-of-care (PoC) analytical platforms. Furthermore, the possibility of routinely multiplexing the detection of tens to hundreds of target sequences with single base pair specificity, currently not met by state-of-the-art methods available in clinical laboratories, would be instrumental along the path to tackle emergent viral variants and antimicrobial resistance genes. Here, we advocate that padlock probes (PLPs), first reported by Nilsson et al. in 1994, coupled with rolling circle amplification (RCA), termed here as PLP-RCA, is an underexploited technology in current arena of isothermal nucleic acid amplification tests (NAATs) providing an unprecedented degree of multiplexing, specificity, versatility, and amenability to integration in miniaturized PoC platforms. Furthermore, the intrinsically digital amplification of PLP-RCA retains spatial information and opens new avenues in the exploration of pathogenesis with spatial multiomics analysis of infected cells and tissue.The Account starts by introducing PLP-RCA in a nutshell focusing individually on the three main assay steps, namely, (1) PLP design and ligation mechanism, (2) RCA after probe ligation, and (3) detection of the RCA products. Each subject is touched upon succinctly but with sufficient detail for the reader to appreciate some assay intricacies and degree of versatility depending on the analytical challenge at hand. After familiarizing the reader with the method, we discuss specific examples of research in our group and others using PLP-RCA for viral, bacterial, and fungal diagnostics in a variety of clinical contexts, including the genotyping of antibiotic resistance genes and viral subtyping. Then, we dissect key developments in the miniaturization and integration of PLP-RCA to minimize user input, maximize analysis throughput, and expedite the time to results, ultimately aiming at PoC applications. These developments include molecular enrichment for maximum sensitivity, spatial arrays to maximize analytical throughput, automation of liquid handling to streamline the analytical workflow in miniaturized devices, and seamless integration of signal transduction to translate RCA product titers (and ideally spatial information) into a readable output. Finally, we position PLP-RCA in the current landscape of NAATs and furnish a systematic Strengths, Weaknesses, Opportunities and Threats analysis to shine light upon unpolished edges to uncover the gem with potential for ubiquitous, precise, and unbiased pathogen diagnostics.", "doi": "10.1021/acs.accounts.1c00438", "pmid": "34637281", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC8567418"}], "notes": [], "created": "2021-10-21T05:29:45.915Z", "modified": "2021-12-07T10:01:21.291Z"}, {"entity": "publication", "iuid": "7c8fb306e45e4631a707195122800f01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7c8fb306e45e4631a707195122800f01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7c8fb306e45e4631a707195122800f01"}}, "title": "Management of personal protective equipment during the COVID-19 pandemic in England and the state of New York: A comparative case study.", "authors": [{"family": "Barber", "given": "Amy", "initials": "A"}, {"family": "Vinzent", "given": "Anna\u00eblle", "initials": "A"}, {"family": "Williams", "given": "Imani", "initials": "I"}], "type": "journal article", "published": "2021-11-02", "journal": {"title": "J Emerg Manag", "issn": "1543-5865", "issn-l": null, "volume": "18", "issue": "7", "pages": "71-89"}, "abstract": "The COVID-19 crisis placed extraordinary demands on the supply of personal protective equipment (PPE) at the beginning of 2020. These were coupled with shocks to the supply chain resulting from the disease. Many typically well-resourced health systems faced subsequent shortages of equipment and had to implement new strategies to manage their stocks. Stockpiles of protective equipment were held in both the United States and United Kingdom intended to prevent shortages.\r\n\r\nCross-comparative case study approach by applying Pettigrew and Whipp's framework for change management.\r\n\r\nThe health systems of England and New York state from January 2020 to the end of April 2020.\r\n\r\nBoth cases reacted slowly to their outbreaks and faced problems with supplying enough PPE to their health systems. Their stockpiles were not enough to prevent shortages, with many distribution problems resulting from inadequate governance mechanisms. No sustainable responses to supply disruptions were implemented during the study period in either case. Health systems planned interventions along each part of the supply chain from production and importing, to usage guidelines.\r\n\r\nGlobal supply chains are vulnerable to disruptions caused by international crises, and existing mitigation strategies have not been wholly successful. The existence of stockpiles is insufficient to preventing shortages of necessary equipment in clinical settings. Both the governance and quality of stockpiles, as well as distribution channels are important for preventing shortages. At the time of writing, it is not possible to judge the strength of strategies adopted in these cases.", "doi": "10.5055/jem.0531", "pmid": "34723349", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "jem.0531"}], "notes": [], "created": "2021-11-02T15:44:29.443Z", "modified": "2021-11-02T15:45:06.409Z"}, {"entity": "publication", "iuid": "a7e380d43e2a49ae9d45952a3a365992", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7e380d43e2a49ae9d45952a3a365992.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7e380d43e2a49ae9d45952a3a365992"}}, "title": "Longitudinal Follow Up of Immune Responses to SARS-CoV-2 in Health Care Workers in Sweden With Several Different Commercial IgG-Assays, Measurement of Neutralizing Antibodies and CD4+ T-Cell Responses.", "authors": [{"family": "Marklund", "given": "Emelie", "initials": "E"}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Lundgren", "given": "Anna", "initials": "A"}, {"family": "Liljeqvist", "given": "Jan-\u00c5ke", "initials": "J\u00c5"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Bemark", "given": "Mats", "initials": "M"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-11-02", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "12", "issue": null, "pages": "750448"}, "abstract": "The risk of SARS-CoV-2 infection among health care workers (HCWs) is a concern, but studies that conclusively determine whether HCWs are over-represented remain limited. Furthermore, methods used to confirm past infection vary and the immunological response after mild COVID-19 is still not well defined.\n\n314 HCWs were recruited from a Swedish Infectious Diseases clinic caring for COVID-19 patients. IgG antibodies were measured using two commercial assays (Abbot Architect nucleocapsid (N)-assay and YHLO iFlash-1800 N and spike (S)-assays) at five time-points, from March 2020 to January 2021, covering two pandemic waves. Seroprevalence was assessed in matched blood donors at three time-points. More extensive analyses were performed in 190 HCWs in September/October 2020, including two additional IgG-assays (DiaSorin LiaisonXL S1/S2 and Abbot Architect receptor-binding domain (RBD)-assays), neutralizing antibodies (NAbs), and CD4+ T-cell reactivity using an in-house developed in vitro whole-blood assay based on flow cytometric detection of activated cells after stimulation with Spike S1-subunit or Spike, Membrane and Nucleocapsid (SMN) overlapping peptide pools.\n\nSeroprevalence was higher among HCWs compared to sex and age-matched blood donors at all time-points. Seropositivity increased from 6.4% to 16.3% among HCWs between May 2020 and January 2021, compared to 3.6% to 11.9% among blood donors. We found significant correlations and high levels of agreement between NAbs and all four commercial IgG-assays. At 200-300 days post PCR-verified infection, there was a wide variation in sensitivity between the commercial IgG-assays, ranging from <30% in the N-assay to >90% in the RBD-assay. There was only moderate agreement between NAbs and CD4+ T-cell reactivity to S1 or SMN. Pre-existing CD4+ T-cell reactivity was present in similar proportions among HCW who subsequently became infected and those that did not.\n\nHCWs in COVID-19 patient care in Sweden have been infected with SARS-CoV-2 at a higher rate compared to blood donors. We demonstrate substantial variation between different IgG-assays and propose that multiple serological targets should be used to verify past infection. Our data suggest that CD4+ T-cell reactivity is not a suitable measure of past infection and does not reliably indicate protection from infection in naive individuals.", "doi": "10.3389/fimmu.2021.750448", "pmid": "34795668", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Research Area: Vaccine": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null, "Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pmc", "key": "PMC8593002"}], "notes": [], "created": "2021-12-13T08:52:58.680Z", "modified": "2022-02-14T15:04:31.373Z"}, {"entity": "publication", "iuid": "d407dcf3c4104c5cac5305cf00d65c47", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d407dcf3c4104c5cac5305cf00d65c47.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d407dcf3c4104c5cac5305cf00d65c47"}}, "title": "Identification and Development of Therapeutics for COVID-19.", "authors": [{"family": "Rando", "given": "Halie M", "initials": "HM", "orcid": "0000-0001-7688-1770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b5a9f4ec1bd48579abca9895dab3ea7.json"}}, {"family": "Wellhausen", "given": "Nils", "initials": "N", "orcid": "0000-0001-8955-7582", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/934767f0228241648d70c7b00527deff.json"}}, {"family": "Ghosh", "given": "Soumita", "initials": "S", "orcid": "0000-0002-2783-2750", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5304077580743148d3d23ee7c77be93.json"}}, {"family": "Lee", "given": "Alexandra J", "initials": "AJ", "orcid": "0000-0002-0208-3730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/761782ce14b542078b3ee6c0db2bb6ce.json"}}, {"family": "Dattoli", "given": "Anna Ada", "initials": "AA", "orcid": "0000-0003-1462-831X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fc8cf6436ef47e99880470f63f5f86a.json"}}, {"family": "Hu", "given": "Fengling", "initials": "F", "orcid": "0000-0003-1081-5038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a309350c038479199dc70af0e80a8e6.json"}}, {"family": "Byrd", "given": "James Brian", "initials": "JB", "orcid": "0000-0002-0509-3520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bc319c5d0d74676875bd9ff266f5e80.json"}}, {"family": "Rafizadeh", "given": "Diane N", "initials": "DN", "orcid": "0000-0002-2838-067X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69c8d2c22f44431ea262b7266d6be0de.json"}}, {"family": "Lordan", "given": "Ronan", "initials": "R", "orcid": "0000-0001-9668-3368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0126a49dfcdf49fcb53041fbdcd91706.json"}}, {"family": "Qi", "given": "Yanjun", "initials": "Y", "orcid": "0000-0002-5796-7453", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d48badb4eff4f4f9bf3f15632f0c3a7.json"}}, {"family": "Sun", "given": "Yuchen", "initials": "Y"}, {"family": "Brueffer", "given": "Christian", "initials": "C", "orcid": "0000-0002-3826-0989", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c4f95c1889f4f098676404aec6125ca.json"}}, {"family": "Field", "given": "Jeffrey M", "initials": "JM", "orcid": "0000-0001-7161-7284", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/851e90805f1a44b2b92711899eedb386.json"}}, {"family": "Ben Guebila", "given": "Marouen", "initials": "M", "orcid": "0000-0001-5934-966X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e04fc9008f7f4307a76515f913f19adf.json"}}, {"family": "Jadavji", "given": "Nafisa M", "initials": "NM", "orcid": "0000-0002-3557-7307", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/202cad28eb7f4f67a152ecc180ad9ffb.json"}}, {"family": "Skelly", "given": "Ashwin N", "initials": "AN", "orcid": "0000-0002-1565-3376", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9818ecec2a65431faf931d73ea71bcb2.json"}}, {"family": "Ramsundar", "given": "Bharath", "initials": "B", "orcid": "0000-0001-8450-4262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/461ff07ac9794d8cb1bc205d94bb193f.json"}}, {"family": "Wang", "given": "Jinhui", "initials": "J", "orcid": "0000-0002-5796-8130", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5243fdc11744ba89697e8fdf9c2feee.json"}}, {"family": "Goel", "given": "Rishi Raj", "initials": "RR", "orcid": "0000-0003-1715-5191", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ad2f4cb84774051bb9422f314ec0f11.json"}}, {"family": "Park", "given": "YoSon", "initials": "Y", "orcid": "0000-0002-0465-4744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d3c095fe591449a8c122645bf540ed5.json"}}, {"family": "COVID-19 Review Consortium  Vikas Bansal,  John P. Barton,  Simina M. Boca,  Joel D. Boerckel,  Christian Brueffer,  James Brian Byrd,  Stephen Capone,  Shikta Das,  Anna Ada Dattoli,  John J. Dziak,  Jeffrey M. Field,  Soumita Ghosh,  Anthony Gitter,  Rishi Raj Goel,  Casey S. Greene,  Marouen Ben Guebila,  Daniel S. Himmelstein,  Fengling Hu,  Nafisa M. Jadavji,  Jeremy P. Kamil,  Sergey Knyazev,  Likhitha Kolla,  Alexandra J. Lee,  Ronan Lordan,  Tiago Lubiana,  Temitayo Lukan,  Adam L. MacLean,  David Mai,  Serghei Mangul,  David Manheim,  Lucy D\u2019Agostino McGowan,  Amruta Naik,  YoSon Park,  Dimitri Perrin,  Yanjun Qi,  Diane N. Rafizadeh,  Bharath Ramsundar,  Halie M. Rando,  Sandipan Ray,  Michael P. Robson,  Vincent Rubinetti,  Elizabeth Sell,  Lamonica Shinholster,  Ashwin N. Skelly,  Yuchen Sun,  Yusha Sun,  Gregory L. Szeto,  Ryan Velazquez,  Jinhui Wang,  Nils Wellhausen", "given": "", "initials": ""}, {"family": "Boca", "given": "Simina M", "initials": "SM", "orcid": "0000-0002-1400-3398", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3eb0ffeffea24d5cb745b5ca86648e60.json"}}, {"family": "Gitter", "given": "Anthony", "initials": "A", "orcid": "0000-0002-5324-9833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7085c8743e3442859ad6f23198c85456.json"}}, {"family": "Greene", "given": "Casey S", "initials": "CS", "orcid": "0000-0001-8713-9213", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42aaaac8b65642538f28f9cd2045ab8d.json"}}], "type": "journal article", "published": "2021-11-02", "journal": {"title": "mSystems", "issn": "2379-5077", "pages": "e0023321", "issn-l": null}, "abstract": "After emerging in China in late 2019, the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread worldwide, and as of mid-2021, it remains a significant threat globally. Only a few coronaviruses are known to infect humans, and only two cause infections similar in severity to SARS-CoV-2: Severe acute respiratory syndrome-related coronavirus, a species closely related to SARS-CoV-2 that emerged in 2002, and Middle East respiratory syndrome-related coronavirus, which emerged in 2012. Unlike the current pandemic, previous epidemics were controlled rapidly through public health measures, but the body of research investigating severe acute respiratory syndrome and Middle East respiratory syndrome has proven valuable for identifying approaches to treating and preventing novel coronavirus disease 2019 (COVID-19). Building on this research, the medical and scientific communities have responded rapidly to the COVID-19 crisis and identified many candidate therapeutics. The approaches used to identify candidates fall into four main categories: adaptation of clinical approaches to diseases with related pathologies, adaptation based on virological properties, adaptation based on host response, and data-driven identification (ID) of candidates based on physical properties or on pharmacological compendia. To date, a small number of therapeutics have already been authorized by regulatory agencies such as the Food and Drug Administration (FDA), while most remain under investigation. The scale of the COVID-19 crisis offers a rare opportunity to collect data on the effects of candidate therapeutics. This information provides insight not only into the management of coronavirus diseases but also into the relative success of different approaches to identifying candidate therapeutics against an emerging disease. IMPORTANCE The COVID-19 pandemic is a rapidly evolving crisis. With the worldwide scientific community shifting focus onto the SARS-CoV-2 virus and COVID-19, a large number of possible pharmaceutical approaches for treatment and prevention have been proposed. What was known about each of these potential interventions evolved rapidly throughout 2020 and 2021. This fast-paced area of research provides important insight into how the ongoing pandemic can be managed and also demonstrates the power of interdisciplinary collaboration to rapidly understand a virus and match its characteristics with existing or novel pharmaceuticals. As illustrated by the continued threat of viral epidemics during the current millennium, a rapid and strategic response to emerging viral threats can save lives. In this review, we explore how different modes of identifying candidate therapeutics have borne out during COVID-19.", "doi": "10.1128/mSystems.00233-21", "pmid": "34726496", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8562484"}], "notes": [], "created": "2021-11-08T09:05:54.814Z", "modified": "2021-11-08T09:05:55.435Z"}, {"entity": "publication", "iuid": "6c2429fdd2724204a56226054af6dd87", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c2429fdd2724204a56226054af6dd87.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c2429fdd2724204a56226054af6dd87"}}, "title": "Youths' and Parents' Experiences and Perceived Effects of Internet-Based Cognitive Behavioral Therapy for Anxiety Disorders in Primary Care: Mixed Methods Study.", "authors": [{"family": "Lilja", "given": "Josefine Lotten", "initials": "JL", "orcid": "0000-0003-3623-5760", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3afa9b5d0b6448a5ba4a74576c5c96ed.json"}}, {"family": "Rupcic Ljustina", "given": "Mirna", "initials": "M", "orcid": "0000-0002-7904-326X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53b6cdc53961456693332fa4df4e77b5.json"}}, {"family": "Nissling", "given": "Linnea", "initials": "L", "orcid": "0000-0001-6479-2973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/efa4203dddeb46abacba7575fd13e6a1.json"}}, {"family": "Larsson", "given": "Anna Caroline", "initials": "AC", "orcid": "0000-0001-7530-3039", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ddc347021dd42018899efe7a3790588.json"}}, {"family": "Weineland", "given": "Sandra", "initials": "S", "orcid": "0000-0003-2428-4004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87597556008d43bf8cdbf52bcc98774b.json"}}], "type": "journal article", "published": "2021-11-01", "journal": {"title": "JMIR Pediatr Parent", "issn": "2561-6722", "volume": "4", "issue": "4", "pages": "e26842", "issn-l": null}, "abstract": "Anxiety is common among youths in primary care. Face-to-face treatment has been the first choice for clinicians, but during the COVID-19 pandemic, digital psychological interventions have substantially increased. Few studies have examined young people's interest in internet treatment or the attitudes they and their parents have toward it.\n\nThis study aims to investigate adolescents' and parents' attitudes toward and experiences of internet-based cognitive behavioral anxiety treatment in primary care and its presumptive effects.\n\nThe study used mixed methods, analyzing qualitative data thematically and quantitative data with nonparametric analysis. Participants were 14 adolescents and 14 parents recruited in adolescent primary health care clinics. The adolescents and their parents filled out mental health questionnaires before and after treatment, and were interviewed during ongoing treatment.\n\nThe quantitative data indicated that the internet-delivered cognitive behavioral therapy program used in this study was successful in reducing symptoms (\u03c722=8.333; P=.02) and that adolescents' motivation is essential to the treatment outcome (r=0.58; P=.03). The qualitative results show that youths highly value their independence and freedom to organize treatment work on their own terms. The parents expressed uncertainty about their role and how to support their child in treatment. It was important for parents to respect the youths' need for autonomy while also engaging with them in the treatment work.\n\nInternet treatment in primary care is accepted by both youths and their parents, who need clarification about the difference between their role and the therapist's role. Patient motivation should be considered before treatment, and therapists need to continue to develop the virtual alliance. Finally, primary care should be clearer in informing adolescents and their parents about the possibility of internet treatment.", "doi": "10.2196/26842", "pmid": "34723830", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "v4i4e26842"}], "notes": [], "created": "2021-11-02T15:45:37.788Z", "modified": "2021-11-02T15:45:53.028Z"}, {"entity": "publication", "iuid": "e441957c608a4603accba1b7e3c65524", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e441957c608a4603accba1b7e3c65524.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e441957c608a4603accba1b7e3c65524"}}, "title": "Transient increased immunoglobulin levels in a hyper-IgM syndrome patient with COVID-19 infection.", "authors": [{"family": "Safarirad", "given": "Molood", "initials": "M"}, {"family": "Ganji", "given": "Ali Abbaszadeh", "initials": "AA"}, {"family": "Nazari", "given": "Farzad", "initials": "F"}, {"family": "Yazdani", "given": "Reza", "initials": "R"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Motlagh", "given": "Ahmad Vosughi", "initials": "AV"}], "type": "case reports", "published": "2021-11-01", "journal": {"title": "Allergol Immunopathol (Madr)", "issn": "1578-1267", "volume": "49", "issue": "6", "pages": "63-66", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people around the world. This zoonotic-enveloped virus is primarily transmitted through inhalation. Infected people are commonly asymptomatic or manifest mild symptoms, including fever, cough, diarrhea, and fatigue. However, it may lead to severe patterns associated with multiple organ failure in individuals with an impaired immune system.\n\nHere we report a 7-year-old girl with hyper-immunoglobulin M (IgM) (HIgM) phenotype, admitted to the hospital emergency department with fever, cough, and pneumonia symptoms because of the COVID-19 infection. Coronavirus infection was confirmed by a positive real-time polymerase chain reaction test. Surprisingly, serum levels of both IgG and IgA of the patient were transiently normalized during the COVID-19 infection when tested prior to the monthly injection of intravenous immunoglobulin. After she recovered from the COVID infection, her immunoglobulin levels returned to the primary stage and she demonstrated HIgM phenotype.\n\nSince this transient increase in the levels of immunoglobulins was solely observed during the COVID-19 infection, and no other infectious episodes were diagnosed in the patient, clarifying the exact cause would help to understand in a better manner the implications and specification of humoral immunity in patients with primary antibody deficiencies.", "doi": "10.15586/aei.v49i6.92", "pmid": "34761659", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T15:17:15.274Z", "modified": "2021-11-26T15:17:15.308Z"}, {"entity": "publication", "iuid": "6a88d04a68fa4a1b84cde55ec30756bc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a88d04a68fa4a1b84cde55ec30756bc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a88d04a68fa4a1b84cde55ec30756bc"}}, "title": "The Role of Perceived Organizational Support in Mental Health of Healthcare Workers During the COVID-19 Pandemic: A Cross-Sectional Study.", "authors": [{"family": "Chatzittofis", "given": "Andreas", "initials": "A"}, {"family": "Constantinidou", "given": "Anastasia", "initials": "A"}, {"family": "Artemiadis", "given": "Artemios", "initials": "A"}, {"family": "Michailidou", "given": "Kyriaki", "initials": "K"}, {"family": "Karanikola", "given": "Maria N K", "initials": "MNK"}], "type": "journal article", "published": "2021-11-01", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "707293", "issn-l": "1664-0640"}, "abstract": "Background: Data support the link between the coronavirus disease 2019 (COVID-19) pandemic and mental distress in healthcare workers (HCWs). Although previous studies have documented the association between organizational policies and employees' psychological and mental status, there is still scant evidence regarding the effect of perceived organizational support (POS) on mental distress in HCWs during the pandemic. Aims: The present study aimed to assess the association between POS and mental distress in HCWs during the COVID-19 pandemic. The role of POS in stress, depressive and trauma symptoms in HCWs was investigated. Methods: This was an online cross-sectional study in 424 HCWs. Data were collected during the first wave of the pandemic, and included demographics, a 7-item questionnaire assessing POS, the \"Patient Health Questionnaire\" assessing depressive symptoms, the \"Impact of Events Scale Revised,\" measuring post-traumatic stress disorder (PTSD) symptoms and the \"Perceived Stress Scale\" assessing perceived stress. Results: The mean POS score was 3.33 [standard deviation:1.85; range 0-7]. Younger (p < 0.001), less experienced (p < 0.001), female (p = 0.002), and non-physician HCWs (p = 0.031) were more likely to report lower self-perceived organizational support than older, male, more experienced physicians. Self-perceived organizational support was significantly and negatively associated with and self-assessed intensity of stress, depressive and traumatic symptoms, after adjusting for putative confounders (p < 0.001). Discussion: Self-perceived organizational support was significantly associated with HCWs' self-assessed mental status during the pandemic. Organizational support and mental distress should be addressed simultaneously in HCWs during the COVID-19 pandemic to increase resilience among them.", "doi": "10.3389/fpsyt.2021.707293", "pmid": "34790134", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8591071"}], "notes": [], "created": "2021-11-26T14:10:56.848Z", "modified": "2021-11-26T14:10:56.860Z"}, {"entity": "publication", "iuid": "d5e8b547d4e5441691d8aed2a6a281ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5e8b547d4e5441691d8aed2a6a281ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5e8b547d4e5441691d8aed2a6a281ae"}}, "title": "COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study.", "authors": [{"family": "Chatzikonstantinou", "given": "Thomas", "initials": "T", "orcid": "0000-0003-4105-1253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/23021761f08c4fefa1086c5c865f5b10.json"}}, {"family": "Kapetanakis", "given": "Anargyros", "initials": "A"}, {"family": "Scarf\u00f2", "given": "Lydia", "initials": "L"}, {"family": "Karakatsoulis", "given": "Georgios", "initials": "G"}, {"family": "Allsup", "given": "David", "initials": "D", "orcid": "0000-0001-6159-6109", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2a3916e351f436e8408a950d209d2e7.json"}}, {"family": "Cabrero", "given": "Alejandro Alonso", "initials": "AA"}, {"family": "Andres", "given": "Martin", "initials": "M", "orcid": "0000-0001-9891-2988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa6138aa170b4ff3a8dd2f86a6470f25.json"}}, {"family": "Antic", "given": "Darko", "initials": "D"}, {"family": "Baile", "given": "M\u00f3nica", "initials": "M"}, {"family": "Baliakas", "given": "Panagiotis", "initials": "P"}, {"family": "Bron", "given": "Dominique", "initials": "D"}, {"family": "Capasso", "given": "Antonella", "initials": "A"}, {"family": "Chatzileontiadou", "given": "Sofia", "initials": "S"}, {"family": "Cordoba", "given": "Raul", "initials": "R"}, {"family": "Correa", "given": "Juan-Gonzalo", "initials": "JG"}, {"family": "Cu\u00e9llar-Garc\u00eda", "given": "Carolina", "initials": "C"}, {"family": "De Paoli", "given": "Lorenzo", "initials": "L"}, {"family": "De Paolis", "given": "Maria Rosaria", "initials": "MR"}, {"family": "Del Poeta", "given": "Giovanni", "initials": "G"}, {"family": "Demosthenous", "given": "Christos", "initials": "C"}, {"family": "Dimou", "given": "Maria", "initials": "M", "orcid": "0000-0001-8197-9895", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7193d5fe6b549c4a2b9786e7572d63f.json"}}, {"family": "Donaldson", "given": "David", "initials": "D"}, {"family": "Doubek", "given": "Michael", "initials": "M", "orcid": "0000-0002-1269-6282", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5407e6865c7045f1bc6e595eb7047eaa.json"}}, {"family": "Efstathopoulou", "given": "Maria", "initials": "M"}, {"family": "Eichhorst", "given": "Barbara", "initials": "B"}, {"family": "El-Ashwah", "given": "Shaimaa", "initials": "S"}, {"family": "Enrico", "given": "Alicia", "initials": "A", "orcid": "0000-0002-1983-6145", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/074670e0454c43a3b9435c0312fc6a35.json"}}, {"family": "Espinet", "given": "Blanca", "initials": "B", "orcid": "0000-0002-4294-8145", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0f362ec00c9449c95b6e68c76c8db2c.json"}}, {"family": "Farina", "given": "Lucia", "initials": "L"}, {"family": "Ferrari", "given": "Angela", "initials": "A"}, {"family": "Foglietta", "given": "Myriam", "initials": "M"}, {"family": "Frederiksen", "given": "Henrik", "initials": "H", "orcid": "0000-0001-8905-0220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dd8e0ff7ffe4154a4bf63e0e2d2ebe5.json"}}, {"family": "F\u00fcrstenau", "given": "Moritz", "initials": "M", "orcid": "0000-0002-6593-0140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e940c65de1ea4811982480c9e043e3ed.json"}}, {"family": "Garc\u00eda-Marco", "given": "Jos\u00e9 A", "initials": "JA", "orcid": "0000-0002-8993-5982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae24000421684dd4b672a42c0175db23.json"}}, {"family": "Garc\u00eda-Serra", "given": "Roc\u00edo", "initials": "R", "orcid": "0000-0003-4857-1016", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64be4a6881bd4ee2bb3cdfe4f98aed63.json"}}, {"family": "Gentile", "given": "Massimo", "initials": "M"}, {"family": "Gimeno", "given": "Eva", "initials": "E"}, {"family": "Glenth\u00f8j", "given": "Andreas", "initials": "A"}, {"family": "Gomes da Silva", "given": "Maria", "initials": "M"}, {"family": "Gutwein", "given": "Odit", "initials": "O"}, {"family": "Hakobyan", "given": "Yervand K", "initials": "YK", "orcid": "0000-0002-9074-7831", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b93ae93cedf140bd818d21a7787a5b18.json"}}, {"family": "Herishanu", "given": "Yair", "initials": "Y"}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jos\u00e9 \u00c1ngel", "initials": "J\u00c1", "orcid": "0000-0003-4550-757X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d071af0c0a14dc695bcda29033b49ce.json"}}, {"family": "Herold", "given": "Tobias", "initials": "T", "orcid": "0000-0002-9615-9432", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce3888ebd0dc407983804c9f7cf2a1d5.json"}}, {"family": "Innocenti", "given": "Idanna", "initials": "I"}, {"family": "Itchaki", "given": "Gilad", "initials": "G"}, {"family": "Jaksic", "given": "Ozren", "initials": "O"}, {"family": "Janssens", "given": "Ann", "initials": "A"}, {"family": "Kalashnikova", "given": "\u041elga B", "initials": "\u041eB", "orcid": "0000-0002-1856-1055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c829e1da08b14c72ad0aa0eafd5b485d.json"}}, {"family": "Kalici\u0144ska", "given": "El\u017cbieta", "initials": "E"}, {"family": "Karlsson", "given": "Linda Katharina", "initials": "LK", "orcid": "0000-0003-3317-7550", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7755dec3898c4e33a5729825a8d2dacd.json"}}, {"family": "Kater", "given": "Arnon P", "initials": "AP"}, {"family": "Kersting", "given": "Sabina", "initials": "S"}, {"family": "Labrador", "given": "Jorge", "initials": "J", "orcid": "0000-0002-3696-0287", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9eab3a75d0294b74a6f9aa9eeb0b32f4.json"}}, {"family": "Lad", "given": "Deepesh", "initials": "D", "orcid": "0000-0003-3754-7774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7beb53ecbdd449e8bee3890151070af0.json"}}, {"family": "Laurenti", "given": "Luca", "initials": "L"}, {"family": "Levin", "given": "Mark-David", "initials": "MD", "orcid": "0000-0003-2139-3547", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf8f1dcff71143b7932a884334bc1eff.json"}}, {"family": "Lista", "given": "Enrico", "initials": "E"}, {"family": "Lopez-Garcia", "given": "Alberto", "initials": "A", "orcid": "0000-0002-5354-5261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c785356a67e4cbb9835fe9ce04a6153.json"}}, {"family": "Malerba", "given": "Lara", "initials": "L"}, {"family": "Marasca", "given": "Roberto", "initials": "R", "orcid": "0000-0002-6431-6878", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d0c310570274da69fb28946c66020e7.json"}}, {"family": "Marchetti", "given": "Monia", "initials": "M", "orcid": "0000-0001-7615-0572", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2fd4079badec41a7a7215d9b8fc37fb4.json"}}, {"family": "Marquet", "given": "Juan", "initials": "J"}, {"family": "Mattsson", "given": "Mattias", "initials": "M"}, {"family": "Mauro", "given": "Francesca R", "initials": "FR"}, {"family": "Milosevic", "given": "Ivana", "initials": "I"}, {"family": "Mir\u00e1s", "given": "Fatima", "initials": "F"}, {"family": "Morawska", "given": "Marta", "initials": "M"}, {"family": "Motta", "given": "Marina", "initials": "M"}, {"family": "Munir", "given": "Talha", "initials": "T"}, {"family": "Murru", "given": "Roberta", "initials": "R"}, {"family": "Niemann", "given": "Carsten U", "initials": "CU", "orcid": "0000-0001-9880-5242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b594ef0644e54a568dbe3de6847c4369.json"}}, {"family": "Rodrigues", "given": "Raquel Nunes", "initials": "RN"}, {"family": "Olivieri", "given": "Jacopo", "initials": "J"}, {"family": "Orsucci", "given": "Lorella", "initials": "L"}, {"family": "Papaioannou", "given": "Maria", "initials": "M"}, {"family": "Pavlovsky", "given": "Miguel Arturo", "initials": "MA"}, {"family": "Piskunova", "given": "Inga", "initials": "I"}, {"family": "Popov", "given": "Viola Maria", "initials": "VM", "orcid": "0000-0002-1200-379X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d0058f0e37c4164adfdc4cff9f162cc.json"}}, {"family": "Quaglia", "given": "Francesca Maria", "initials": "FM", "orcid": "0000-0003-4347-3775", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81838e15a03441b88702c3449ef0c4d1.json"}}, {"family": "Quaresmini", "given": "Giulia", "initials": "G", "orcid": "0000-0002-0993-9693", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fb23db20963401a96c3ac6e030259ae.json"}}, {"family": "Qvist", "given": "Kristian", "initials": "K"}, {"family": "Reda", "given": "Gianluigi", "initials": "G", "orcid": "0000-0003-4687-7089", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ecd84c2c9bf44fd8c7635c1420621a4.json"}}, {"family": "Rigolin", "given": "Gian Matteo", "initials": "GM", "orcid": "0000-0002-8370-5190", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e7020e591b04b72ac7ee221f8b262ba.json"}}, {"family": "Ruchlemer", "given": "Rosa", "initials": "R"}, {"family": "Saghumyan", "given": "Gevorg", "initials": "G"}, {"family": "Shrestha", "given": "Amit", "initials": "A"}, {"family": "\u0160imkovi\u010d", "given": "Martin", "initials": "M"}, {"family": "\u0160pa\u010dek", "given": "Martin", "initials": "M"}, {"family": "Sportoletti", "given": "Paolo", "initials": "P"}, {"family": "Stanca", "given": "Oana", "initials": "O"}, {"family": "Stavroyianni", "given": "Niki", "initials": "N"}, {"family": "Tadmor", "given": "Tamar", "initials": "T", "orcid": "0000-0002-3435-8612", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c968d69d0b545aaa6c99104419ac961.json"}}, {"family": "Te Raa", "given": "Doreen", "initials": "D"}, {"family": "Tonino", "given": "Sanne H", "initials": "SH"}, {"family": "Trentin", "given": "Livio", "initials": "L", "orcid": "0000-0003-1222-6149", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/affdda253d72414db28ee8e2d7682835.json"}}, {"family": "Van Der Spek", "given": "Ellen", "initials": "E"}, {"family": "van Gelder", "given": "Michel", "initials": "M"}, {"family": "van Kampen", "given": "Roel", "initials": "R"}, {"family": "Varettoni", "given": "Marzia", "initials": "M"}, {"family": "Visentin", "given": "Andrea", "initials": "A"}, {"family": "Vitale", "given": "Candida", "initials": "C", "orcid": "0000-0002-2592-8724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/654bf15e55d64f3cb3e3c43657f57c64.json"}}, {"family": "Wasik-Szczepanek", "given": "Ewa", "initials": "E"}, {"family": "Wr\u00f3bel", "given": "Tomasz", "initials": "T"}, {"family": "San Segundo", "given": "Lucrecia Y\u00e1\u00f1ez", "initials": "LY"}, {"family": "Yassin", "given": "Mohamed", "initials": "M"}, {"family": "Coscia", "given": "Marta", "initials": "M"}, {"family": "Rambaldi", "given": "Alessandro", "initials": "A"}, {"family": "Montserrat", "given": "Emili", "initials": "E"}, {"family": "Fo\u00e0", "given": "Robin", "initials": "R", "orcid": "0000-0002-5021-3026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/058a918147d247a2b0e64bca35a84ef1.json"}}, {"family": "Cuneo", "given": "Antonio", "initials": "A"}, {"family": "Stamatopoulos", "given": "Kostas", "initials": "K", "orcid": "0000-0001-8529-640X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a516e0bd6e842e5ac5c023013d6862a.json"}}, {"family": "Ghia", "given": "Paolo", "initials": "P", "orcid": "0000-0003-3750-7342", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e306a735d4d402886e386e15bfc117a.json"}}], "type": "journal article", "published": "2021-11-01", "journal": {"title": "Leukemia", "issn": "1476-5551", "issn-l": null}, "abstract": "Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41-0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02-1.04; HR = 1.79, 95% CI:1.04-3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.", "doi": "10.1038/s41375-021-01450-8", "pmid": "34725454", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41375-021-01450-8"}, {"db": "pmc", "key": "PMC8559135"}], "notes": [], "created": "2021-11-08T09:05:36.612Z", "modified": "2021-11-08T09:05:37.508Z"}, {"entity": "publication", "iuid": "b08deb7e4eb84c94955fbab22705a606", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b08deb7e4eb84c94955fbab22705a606.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b08deb7e4eb84c94955fbab22705a606"}}, "title": "Antibody response to COVID-19 mRNA vaccine (Comirnaty) in myeloma patients treated with high-dose melphalan and/or immunotherapy.", "authors": [{"family": "Lockmer", "given": "Sandra", "initials": "S"}, {"family": "Uttervall", "given": "Katarina", "initials": "K"}, {"family": "Kashif", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-7545-8548", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5441406f8f5343afa5e2cf8862fafc34.json"}}, {"family": "Sv\u00e4rd", "given": "Carina", "initials": "C"}, {"family": "Malmsten", "given": "Katarina", "initials": "K"}, {"family": "Fletcher-Torres", "given": "Evellyn", "initials": "E"}, {"family": "Alici", "given": "Evren", "initials": "E"}, {"family": "Lund", "given": "Johan", "initials": "J"}, {"family": "Nahi", "given": "Hareth", "initials": "H"}], "type": "letter", "published": "2021-11-01", "journal": {"title": "Am J Hematol", "issn": "0361-8609", "issn-l": null, "volume": "96", "issue": "11", "pages": "E443-E446"}, "abstract": null, "doi": "10.1002/ajh.26348", "pmid": "34524709", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-09-20T06:20:49.999Z", "modified": "2021-11-29T06:14:03.414Z"}, {"entity": "publication", "iuid": "ee59d1bd5bd64046968130fc3e8c53d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee59d1bd5bd64046968130fc3e8c53d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee59d1bd5bd64046968130fc3e8c53d4"}}, "title": "A trans-national examination of the impact of the COVID-19 pandemic on abortion requests through a telemedicine service", "authors": [{"family": "van Ooijen", "given": "Li\u00ebn Trudi", "initials": "LT"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}, {"family": "Gomperts", "given": "Rebecca", "initials": "R"}, {"family": "Waltz", "given": "Mitzi", "initials": "M", "orcid": "0000-0002-9089-2545", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/afe1d32b56984165980321020e20b071.json"}}], "type": "journal-article", "published": "2021-11-01", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-1991", "pages": "bmjsrh-2021-201159", "issn-l": null}, "abstract": null, "doi": "10.1136/bmjsrh-2021-201159", "pmid": null, "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-11-02T15:46:57.720Z", "modified": "2021-11-02T15:46:57.782Z"}, {"entity": "publication", "iuid": "f77db87c3a68476492f41c818af91eb0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f77db87c3a68476492f41c818af91eb0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f77db87c3a68476492f41c818af91eb0"}}, "title": "Virological and immunological features of SARS-COV-2 infected children with distinct symptomatology.", "authors": [{"family": "Cotugno", "given": "Nicola", "initials": "N"}, {"family": "Ruggiero", "given": "Alessandra", "initials": "A"}, {"family": "Pascucci", "given": "Giuseppe Rubens", "initials": "GR"}, {"family": "Bonfante", "given": "Francesco", "initials": "F"}, {"family": "Petrara", "given": "Maria Raffaella", "initials": "MR"}, {"family": "Pighi", "given": "Chiara", "initials": "C"}, {"family": "Cifaldi", "given": "Loredana", "initials": "L"}, {"family": "Zangari", "given": "Paola", "initials": "P"}, {"family": "Bernardi", "given": "Stefania", "initials": "S"}, {"family": "Cursi", "given": "Laura", "initials": "L"}, {"family": "Santilli", "given": "Veronica", "initials": "V"}, {"family": "Manno", "given": "Emma Concetta", "initials": "EC"}, {"family": "Amodio", "given": "Donato", "initials": "D"}, {"family": "Linardos", "given": "Giulia", "initials": "G"}, {"family": "Piccioni", "given": "Livia", "initials": "L"}, {"family": "Barbieri", "given": "Maria Antonietta", "initials": "MA"}, {"family": "Perrotta", "given": "Daniela", "initials": "D"}, {"family": "Campana", "given": "Andrea", "initials": "A"}, {"family": "Don\u00e0", "given": "Daniele", "initials": "D"}, {"family": "Giaquinto", "given": "Carlo", "initials": "C"}, {"family": "CACTUS Study Team", "given": "", "initials": ""}, {"family": "Concato", "given": "Carlo", "initials": "C"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "Rossi", "given": "Paolo", "initials": "P"}, {"family": "De Rossi", "given": "Anita", "initials": "A"}, {"family": "Palma", "given": "Paolo", "initials": "P", "orcid": "0000-0002-3066-4719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36e1a02e86a142c2b2d131154fb46f1c.json"}}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Pediatr Allergy Immunol", "issn": "1399-3038", "issn-l": null, "volume": "32", "issue": "8", "pages": "1833-1842"}, "abstract": "Although SARS-CoV-2 immunizations have started in most countries, children are not currently included in the vaccination programs; thus, it remains crucial to define their anti-SARS-CoV-2 immune response in order to minimize the risk for other epidemic waves. This study sought to provide a description of the virology ad anti-SARS-CoV-2 immunity in children with distinct symptomatology.\n\nBetween March and July 2020, we recruited 15 SARS-CoV-2 asymptomatic (AS) and 51 symptomatic (SY) children, stratified according to WHO clinical classification. We measured SARS-CoV-2 viral load using ddPCR and qPCR in longitudinally collected nasopharyngeal swab samples. To define anti-SARS-CoV-2 antibodies, we measured neutralization activity and total IgG load (DiaSorin). We also evaluated antigen-specific B and CD8+T cells, using a labeled S1+S2 protein and ICAM expression, respectively. Plasma protein profiling was performed with Olink.\n\nVirological profiling showed that AS patients had lower viral load at diagnosis (p = .004) and faster virus clearance (p = .0002) compared with SY patients. Anti-SARS-CoV-2 humoral and cellular response did not appear to be associated with the presence of symptoms. AS and SY patients showed similar titers of SARS-CoV-2 IgG, levels of neutralizing activity, and frequency of Ag-specific B and CD8+ T cells, whereas pro-inflammatory plasma protein profile was found to be associated with symptomatology.\n\nWe demonstrated the development of anti-SARS-CoV-2 humoral and cellular response with any regard to symptomatology, suggesting the ability of both SY and AS patients to contribute toward herd immunity. The virological profiling of AS patients suggested that they have lower virus load associated with faster virus clearance.", "doi": "10.1111/pai.13585", "pmid": "34174102", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8420243"}], "notes": [], "created": "2021-06-28T17:53:46.908Z", "modified": "2023-06-19T15:17:49.739Z"}, {"entity": "publication", "iuid": "2bbb4b1d4816465e817881ddb995850c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2bbb4b1d4816465e817881ddb995850c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2bbb4b1d4816465e817881ddb995850c"}}, "title": "The impact of public health interventions in the Nordic countries during the first year of SARS-CoV-2 transmission and evolution.", "authors": [{"family": "Duchene", "given": "Sebastian", "initials": "S"}, {"family": "Featherstone", "given": "Leo", "initials": "L"}, {"family": "Freiesleben de Blasio", "given": "Birgitte", "initials": "B"}, {"family": "Holmes", "given": "Edward C", "initials": "EC"}, {"family": "Bohlin", "given": "Jon", "initials": "J"}, {"family": "Pettersson", "given": "John H-O", "initials": "JH"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "44", "issn-l": null}, "abstract": "BackgroundMany countries have attempted to mitigate and control COVID-19 through non-pharmaceutical interventions, particularly with the aim of reducing population movement and contact. However, it remains unclear how the different control strategies impacted the local phylodynamics of the causative SARS-CoV-2 virus.AimWe aimed to assess the duration of chains of virus transmission within individual countries and the extent to which countries exported viruses to their geographical neighbours.MethodsWe analysed complete SARS-CoV-2 genomes to infer the relative frequencies of virus importation and exportation, as well as virus transmission dynamics, in countries of northern Europe. We examined virus evolution and phylodynamics in Denmark, Finland, Iceland, Norway and Sweden during the first year of the COVID-19 pandemic.ResultsThe Nordic countries differed markedly in the invasiveness of control strategies, which we found reflected in transmission chain dynamics. For example, Sweden, which compared with the other Nordic countries relied more on recommendation-based rather than legislation-based mitigation interventions, had transmission chains that were more numerous and tended to have more cases. This trend increased over the first 8 months of 2020. Together with Denmark, Sweden was a net exporter of SARS-CoV-2. Norway and Finland implemented legislation-based interventions; their transmission chain dynamics were in stark contrast to their neighbouring country Sweden.ConclusionSweden constituted an epidemiological and evolutionary refugium that enabled the virus to maintain active transmission and spread to other geographical locations. Our analysis reveals the utility of genomic surveillance where monitoring of active transmission chains is a key metric.", "doi": "10.2807/1560-7917.ES.2021.26.44.2001996", "pmid": "34738512", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8569925"}], "notes": [], "created": "2021-11-08T09:17:03.828Z", "modified": "2021-11-26T15:40:09.852Z"}, {"entity": "publication", "iuid": "fe9e07f2554c481b8ee7ea06b75e911f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fe9e07f2554c481b8ee7ea06b75e911f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fe9e07f2554c481b8ee7ea06b75e911f"}}, "title": "Risk of SARS-CoV-2 exposure among hospital healthcare workers in relation to patient contact and type of care.", "authors": [{"family": "Klevebro", "given": "Susanna", "initials": "S", "orcid": "0000-0002-1261-6502", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e192d615f8648c0ae28b5ccaf1d6803.json"}}, {"family": "Bahram", "given": "Fuad", "initials": "F"}, {"family": "Elfstr\u00f6m", "given": "K Miriam", "initials": "KM"}, {"family": "Hellberg", "given": "Ulrika", "initials": "U"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Merid", "given": "Simon Kebede", "initials": "SK"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Tornvall", "given": "Per", "initials": "P"}, {"family": "Wang", "given": "Gang", "initials": "G"}, {"family": "Conneryd Lundgren", "given": "Kalle", "initials": "K"}, {"family": "Ponzer", "given": "Sari", "initials": "S"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E", "orcid": "0000-0002-8248-0663", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58e96082947e4752a23f322e42754097.json"}}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": "49", "issue": "7", "pages": "707-712"}, "abstract": "We aimed to assess prevalence of IgG antibodies to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and factors associated with seropositivity in a large cohort of healthcare workers (HCWs).\n\nFrom 11 May until 11 June 2020, 3981 HCWs at a large Swedish emergency care hospital provided serum samples and questionnaire data. Presence of IgG antibodies to SARS-CoV-2 was measured as an indicator of SARS-CoV-2 exposure.\n\nThe total seroprevalence was 18% and increased during the study period. Among the seropositive HCWs, 11% had been entirely asymptomatic. Participants who worked with COVID-19 patients had higher odds for seropositivity: adjusted odds ratio 1.96 (95% confidence intervals 1.59-2.42). HCWs from three of the departments managing COVID-19 patients had significantly higher seroprevalences, whereas the prevalence among HCWs from the intensive care unit (also managing COVID-19 patients) was significantly lower.\n\nHCWs in contact with SARS-CoV-2 infected patients had a variable, but on average higher, likelihood for SARS-CoV-2 infections.", "doi": "10.1177/14034948211022434", "pmid": "34148454", "labels": {"Funder: KAW/SciLifeLab": null, "Research Area: High-throughput and high-content serology": null, "Funder: VR": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8521364"}], "notes": [], "created": "2021-01-29T17:26:04.393Z", "modified": "2023-06-19T15:25:12.116Z"}, {"entity": "publication", "iuid": "24f0afc328f44bff9346ba4f3046ff91", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24f0afc328f44bff9346ba4f3046ff91.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24f0afc328f44bff9346ba4f3046ff91"}}, "title": "Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021.", "authors": [{"family": "Benschop", "given": "Kimberley Sm", "initials": "KS"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Anton", "given": "Andres", "initials": "A"}, {"family": "Andr\u00e9s", "given": "Cristina", "initials": "C"}, {"family": "Aranzamendi", "given": "Maitane", "initials": "M"}, {"family": "Armannsd\u00f3ttir", "given": "Brynja", "initials": "B"}, {"family": "Bailly", "given": "Jean-Luc", "initials": "JL"}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Baldvinsd\u00f3ttir", "given": "Gu\u00f0r\u00fan Erna", "initials": "GE"}, {"family": "Beard", "given": "Stuart", "initials": "S"}, {"family": "Berginc", "given": "Natasa", "initials": "N"}, {"family": "B\u00f6ttcher", "given": "Sindy", "initials": "S"}, {"family": "Blomqvist", "given": "Soile", "initials": "S"}, {"family": "Bubba", "given": "Laura", "initials": "L"}, {"family": "Calvo", "given": "Cristina", "initials": "C"}, {"family": "Cabrerizo", "given": "Maria", "initials": "M"}, {"family": "Cavallero", "given": "Annalisa", "initials": "A"}, {"family": "Celma", "given": "Cristina", "initials": "C"}, {"family": "Ceriotti", "given": "Ferruccio", "initials": "F"}, {"family": "Costa", "given": "In\u00eas", "initials": "I"}, {"family": "Cottrell", "given": "Simon", "initials": "S"}, {"family": "Del Cuerpo", "given": "Margarita", "initials": "M"}, {"family": "Dean", "given": "Jonathan", "initials": "J"}, {"family": "Dembinski", "given": "Jennifer L", "initials": "JL"}, {"family": "Diedrich", "given": "Sabine", "initials": "S"}, {"family": "Diez-Domingo", "given": "Javier", "initials": "J"}, {"family": "Dorenberg", "given": "DagnyHaug", "initials": "D"}, {"family": "Duizer", "given": "Erwin", "initials": "E"}, {"family": "Dyrdak", "given": "Robert", "initials": "R"}, {"family": "Fanti", "given": "Diana", "initials": "D"}, {"family": "Farkas", "given": "Agnes", "initials": "A"}, {"family": "Feeney", "given": "Susan", "initials": "S"}, {"family": "Flipse", "given": "Jacky", "initials": "J"}, {"family": "De Gascun", "given": "Cillian", "initials": "C"}, {"family": "Galli", "given": "Cristina", "initials": "C"}, {"family": "Georgieva", "given": "Irina", "initials": "I"}, {"family": "Gifford", "given": "Laura", "initials": "L"}, {"family": "Guiomar", "given": "Raquel", "initials": "R"}, {"family": "H\u00f6nemann", "given": "Mario", "initials": "M"}, {"family": "Ikonen", "given": "Niina", "initials": "N"}, {"family": "Jeanno\u00ebl", "given": "Marion", "initials": "M"}, {"family": "Josset", "given": "Laurence", "initials": "L"}, {"family": "Keeren", "given": "Kathrin", "initials": "K"}, {"family": "L\u00f3pez-Labrador", "given": "F Xavier", "initials": "FX"}, {"family": "Maier", "given": "Melanie", "initials": "M"}, {"family": "McKenna", "given": "James", "initials": "J"}, {"family": "Meijer", "given": "Adam", "initials": "A"}, {"family": "Mengual-Chuli\u00e1", "given": "Beatriz", "initials": "B"}, {"family": "Midgley", "given": "Sofie E", "initials": "SE"}, {"family": "Mirand", "given": "Audrey", "initials": "A"}, {"family": "Montes", "given": "Milagrosa", "initials": "M"}, {"family": "Moore", "given": "Catherine", "initials": "C"}, {"family": "Morley", "given": "Ursula", "initials": "U"}, {"family": "Murk", "given": "Jean-Luc", "initials": "JL"}, {"family": "Nikolaeva-Glomb", "given": "Lubomira", "initials": "L"}, {"family": "Numanovic", "given": "Sanela", "initials": "S"}, {"family": "Oggioni", "given": "Massimo", "initials": "M"}, {"family": "Palminha", "given": "Paula", "initials": "P"}, {"family": "Pariani", "given": "Elena", "initials": "E"}, {"family": "Pellegrinelli", "given": "Laura", "initials": "L"}, {"family": "Piralla", "given": "Antonio", "initials": "A"}, {"family": "Pietsch", "given": "Corinna", "initials": "C"}, {"family": "Pi\u00f1eiro", "given": "Luis", "initials": "L"}, {"family": "Rabella", "given": "N\u00faria", "initials": "N"}, {"family": "Rainetova", "given": "Petra", "initials": "P"}, {"family": "Uceda Renteria", "given": "Sara Colonia", "initials": "SC"}, {"family": "Romero", "given": "Mar\u00eda P", "initials": "MP"}, {"family": "Reynders", "given": "Marijke", "initials": "M"}, {"family": "Roorda", "given": "Lieuwe", "initials": "L"}, {"family": "Savolainen-Kopra", "given": "Carita", "initials": "C"}, {"family": "Schuffenecker", "given": "Isabelle", "initials": "I"}, {"family": "Soynova", "given": "Aysa", "initials": "A"}, {"family": "Swanink", "given": "Caroline Ma", "initials": "CM"}, {"family": "Ursic", "given": "Tina", "initials": "T"}, {"family": "Verweij", "given": "Jaco J", "initials": "JJ"}, {"family": "Vila", "given": "Jorgina", "initials": "J"}, {"family": "Vuorinen", "given": "Tytti", "initials": "T"}, {"family": "Simmonds", "given": "Peter", "initials": "P"}, {"family": "Fischer", "given": "Thea K", "initials": "TK"}, {"family": "Harvala", "given": "Heli", "initials": "H"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "45", "issn-l": null}, "abstract": "We report a rapid increase in enterovirus D68 (EV-D68) infections, with 139 cases reported from eight European countries between 31 July and 14 October 2021. This upsurge is in line with the seasonality of EV-D68 and was presumably stimulated by the widespread reopening after COVID-19 lockdown. Most cases were identified in September, but more are to be expected in the coming months. Reinforcement of clinical awareness, diagnostic capacities and surveillance of EV-D68 is urgently needed in Europe.", "doi": "10.2807/1560-7917.ES.2021.26.45.2100998", "pmid": "34763750", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8646978"}], "notes": [], "created": "2021-11-26T15:15:11.761Z", "modified": "2023-06-19T14:43:53.882Z"}, {"entity": "publication", "iuid": "e686547fbd854c61b8cef013d5938d3b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e686547fbd854c61b8cef013d5938d3b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e686547fbd854c61b8cef013d5938d3b"}}, "title": "Predictors of severe COVID-19 in a registry-based Swedish cohort of patients with COPD", "authors": [{"family": "Stridsman", "given": "Caroline", "initials": "C", "orcid": "0000-0001-6622-3838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e2fc66fb68748eba5a7f8eb93c5ff3f.json"}}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW", "orcid": "0000-0002-4387-4096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bb5d1f761ef48c4837ed4f984717f0e.json"}}, {"family": "Konradsen", "given": "Jon R", "initials": "JR", "orcid": "0000-0001-7745-8624", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12c585ede9a64cb593a6dc5dbd5f02ed.json"}}, {"family": "Axelsson Fisk", "given": "Sten", "initials": "S"}, {"family": "Pedroletti", "given": "Christophe", "initials": "C"}, {"family": "Sj\u00f6\u00f6", "given": "Yvonne", "initials": "Y"}, {"family": "Syk", "given": "J\u00f6rgen", "initials": "J"}, {"family": "Sterner", "given": "Therese", "initials": "T"}, {"family": "Lindberg", "given": "Anne", "initials": "A", "orcid": "0000-0002-3292-7471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc3222a49f994e7cb8812c32e24c3a73.json"}}, {"family": "Tuns\u00e4ter", "given": "Alf", "initials": "A"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ekberg-Jansson", "given": "Ann", "initials": "A"}, {"family": "Karlsson Sundbaum", "given": "Johanna", "initials": "J"}], "type": "journal-article", "published": "2021-11-00", "journal": {"title": "Eur Respir J", "issn": "0903-1936", "issn-l": null, "volume": "58", "issue": "5", "pages": "2101920"}, "abstract": null, "doi": "10.1183/13993003.01920-2021", "pmid": "34413151", "labels": {"Type: Journal article": null, "Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [], "notes": [], "created": "2021-08-20T12:36:17.060Z", "modified": "2021-12-06T14:30:39.904Z"}, {"entity": "publication", "iuid": "3acc45d672b949c2bdc96cff5a2f37e9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3acc45d672b949c2bdc96cff5a2f37e9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3acc45d672b949c2bdc96cff5a2f37e9"}}, "title": "Plasma endostatin correlates with hypoxia and mortality in COVID-19-associated acute respiratory failure.", "authors": [{"family": "Asif", "given": "Sana", "initials": "S", "orcid": "0000-0001-7924-0936", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/336d0f6c0519467b848a7c05790665d8.json"}}, {"family": "Ruge", "given": "Thoralph", "initials": "T", "orcid": "0000-0002-1170-5183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d6fd0aae4374003924cfcc1acd004a9.json"}}, {"family": "Larsson", "given": "Anders", "initials": "A", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2be858ab604743b72383dfdcd14689.json"}}, {"family": "Anderberg", "given": "Sara B\u00fclow", "initials": "SB"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Fritiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}], "type": "clinical trial", "published": "2021-11-00", "journal": {"title": "Biomark Med", "issn": "1752-0371", "volume": "15", "issue": "16", "pages": "1509-1517", "issn-l": null}, "abstract": "Background: The contribution of endothelial injury in the pathogenesis of COVID-19-associated acute respiratory distress syndrome (ARDS) and resulting respiratory failure remains unclear. Plasma endostatin, an endogenous inhibitor of angiogenesis and endothelial dysfunction is upregulated during hypoxia, inflammation and progress of pulmonary disease. Aim: To investigate if plasma endostatin is associated to hypoxia, inflammation and 30-day mortality in patients with severe COVID-19 infection. Method: Samples for blood analysis and plasma endostatin quantification were collected from adult patients with ongoing COVID-19 (n = 109) on admission to intensive care unit (day 1). Demographic characteristics and 30-day mortality data were extracted from medical records. The ability of endostatin to predict mortality was analyzed using receiving operating characteristics and Kaplan-Meier analysis with a cutoff at 46.2 ng/ml was used to analyze the association to survival. Results: Plasma endostatin levels correlated with; PaO2/FiO2 (r = -0.3, p < 0.001), arterial oxygen tension (r = -0.2, p = 0.01), lactate (r = 0.2, p = 0.04), C-reactive protein (r = 0.2, p = 0.04), ferritin (r = 0.2, p = 0.09), D-dimer (r = 0.2, p = 0.08) and IL-6 (r = 0.4, p < 0.001). Nonsurvivors at 30 days had higher plasma endostatin levels than survivors (72 \u00b1 26 vs 56 \u00b1 16 ng/ml, p = 0.01). Receiving operating characteristic curve (area under the curve 0.7) showed that plasma endostatin >46.2 ng/ml predicts mortality with a sensitivity of 92% and specificity of 71%. In patients with plasma endostatin >46.2 ng/ml probability of survival was lower (p = 0.02) in comparison to those with endostatin <46.2 ng/ml. Conclusion: Our results suggest that plasma endostatin is an early biomarker for disease severity in COVID-19.", "doi": "10.2217/bmm-2021-0111", "pmid": "34668393", "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC8547279"}], "notes": [], "created": "2021-10-21T04:38:51.737Z", "modified": "2021-12-12T18:10:59.396Z"}, {"entity": "publication", "iuid": "fdfafb1234274fd1ad40058ec2ffc6d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fdfafb1234274fd1ad40058ec2ffc6d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fdfafb1234274fd1ad40058ec2ffc6d0"}}, "title": "Meta-analysis of the clinical performance of commercial SARS-CoV-2 nucleic acid and antibody tests up to 22 August 2020.", "authors": [{"family": "Van Walle", "given": "Ivo", "initials": "I"}, {"family": "Leitmeyer", "given": "Katrin", "initials": "K"}, {"family": "Broberg", "given": "Eeva K", "initials": "EK"}, {"family": "European COVID-19 microbiological laboratories group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "45", "issn-l": null}, "abstract": "BackgroundReliable testing for SARS-CoV-2 is key for the management of the COVID-19 pandemic.AimWe estimate diagnostic accuracy for nucleic acid and antibody tests 5 months into the COVID-19 pandemic, and compare with manufacturer-reported accuracy.MethodsWe reviewed the clinical performance of SARS-CoV-2 nucleic acid and antibody tests based on 93,757 test results from 151 published studies and 20,205 new test results from 12 countries in the European Union and European Economic Area (EU/EEA).ResultsPooling the results and considering only results with 95% confidence interval width \u2264 5%, we found four nucleic acid tests, including one point-of-care test and three antibody tests, with a clinical sensitivity \u2265 95% for at least one target population (hospitalised, mild or asymptomatic, or unknown). Nine nucleic acid tests and 25 antibody tests, 12 of them point-of-care tests, had a clinical specificity of \u2265 98%. Three antibody tests achieved both thresholds. Evidence for nucleic acid point-of-care tests remains scarce at present, and sensitivity varied substantially. Study heterogeneity was low for eight of 14 sensitivity and 68 of 84 specificity results with confidence interval width \u2264 5%, and lower for nucleic acid tests than antibody tests. Manufacturer-reported clinical performance was significantly higher than independently assessed in 11 of 32 and four of 34 cases, respectively, for sensitivity and specificity, indicating a need for improvement in this area.ConclusionContinuous monitoring of clinical performance within more clearly defined target populations is needed.", "doi": "10.2807/1560-7917.ES.2021.26.45.2001675", "pmid": "34763752", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T15:14:55.635Z", "modified": "2021-11-26T15:14:55.648Z"}, {"entity": "publication", "iuid": "16b928a1028b4122b7001d154096d8d3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16b928a1028b4122b7001d154096d8d3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16b928a1028b4122b7001d154096d8d3"}}, "title": "Mental health and well-being during COVID-19 lockdown: A survey case report of high-level male and female players of an Italian Serie A football club.", "authors": [{"family": "Ivarsson", "given": "Andreas", "initials": "A", "orcid": "0000-0002-8987-5975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e77e48568e184548a5da063cb6b339be.json"}}, {"family": "McCall", "given": "Alan", "initials": "A", "orcid": "0000-0003-3780-8153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/128f2983992a4f9b95332e3a130c9aaa.json"}}, {"family": "Mutch", "given": "Stephen", "initials": "S"}, {"family": "Giuliani", "given": "Alessia", "initials": "A"}, {"family": "Bassetto", "given": "Rita", "initials": "R"}, {"family": "Fanchini", "given": "Maurizio", "initials": "M"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Sci Med Footb", "issn": "2473-4446", "volume": "5", "issue": "sup1", "pages": "70-75", "issn-l": null}, "abstract": "To describe high-level footballers' levels and changes in mental health and well-being throughout a 8-week period of lockdown and restricted training during the COVID-19 pandemic.\n\nOne-hundred and one players belonging to four teams (women's and men's, first and U19 teams) of the same Italian Serie A club participated in the study. Data were collected through an online questionnaire, and administered at 2, 3, 5, 7 and 9 weeks after the start of the lockdown . Well-being, positive and negative affects measurements were examined.\n\nAcross the five measures, 36% of players reported clinical levels in depressive symptoms (scores \u226450) on at least one occasion. Thirteen percent of the players reported clinical levels on > 50% of the occasions. There was a decrease in depressive symptoms and negative affects over the period. No change was found in positive affects.\n\nHigh number of players reportedclinical levels of depressive symptoms compared to what was found previously in high-level athletes. The number decrease during the 8-week period. A similar trend was found for negative affects.Despite a higher prevalence in depressive symptoms earlier during lockdown, this improved as players progressed towards fewer restrictions.", "doi": "10.1080/24733938.2021.1962540", "pmid": "35077318", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-26T08:23:20.767Z", "modified": "2022-01-26T08:23:20.850Z"}, {"entity": "publication", "iuid": "b0c2ec5ca4eb4f45a757c95cf83e92ad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b0c2ec5ca4eb4f45a757c95cf83e92ad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b0c2ec5ca4eb4f45a757c95cf83e92ad"}}, "title": "Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia: The COVID STEROID randomised, placebo-controlled trial.", "authors": [{"family": "Munch", "given": "Marie Warrer", "initials": "MW", "orcid": "0000-0003-1127-9599", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd56f64f991042da935f6f3836e087b0.json"}}, {"family": "Meyhoff", "given": "Tine Sylvest", "initials": "TS", "orcid": "0000-0002-1840-1596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/766fe5fd044944faabf6a96e8d6a72f0.json"}}, {"family": "Helleberg", "given": "Marie", "initials": "M"}, {"family": "Kjaer", "given": "Maj-Brit N\u00f8rregaard", "initials": "MN", "orcid": "0000-0002-6536-0504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df8fa07399b448a5b689089e505dab58.json"}}, {"family": "Granholm", "given": "Anders", "initials": "A"}, {"family": "Hjorts\u00f8", "given": "Carl Johan Steensen", "initials": "CJS", "orcid": "0000-0003-0413-9715", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/669b4f267a51406e9f074db4ba66629f.json"}}, {"family": "Jensen", "given": "Thomas Steen", "initials": "TS"}, {"family": "M\u00f8ller", "given": "Morten Hylander", "initials": "MH", "orcid": "0000-0002-6378-9673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1cf88aaa5c9436a8e70ddfe39cfe4e8.json"}}, {"family": "Hjortrup", "given": "Peter Buhl", "initials": "PB"}, {"family": "Wetterslev", "given": "Mik", "initials": "M", "orcid": "0000-0002-8798-1133", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9848ee20a294a7da581dec0d23383c7.json"}}, {"family": "Vesterlund", "given": "Gitte Kingo", "initials": "GK", "orcid": "0000-0001-5221-3938", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6eb5ff4bc5054887bfac267b8c8af411.json"}}, {"family": "Russell", "given": "Lene", "initials": "L"}, {"family": "J\u00f8rgensen", "given": "Vibeke Lind", "initials": "VL"}, {"family": "Kristiansen", "given": "Klaus Tjelle", "initials": "KT"}, {"family": "Benfield", "given": "Thomas", "initials": "T"}, {"family": "Ulrik", "given": "Charlotte Suppli", "initials": "CS"}, {"family": "Andreasen", "given": "Anne Sofie", "initials": "AS"}, {"family": "Bestle", "given": "Morten Heiberg", "initials": "MH"}, {"family": "Poulsen", "given": "Lone Musaeus", "initials": "LM"}, {"family": "Hildebrandt", "given": "Thomas", "initials": "T"}, {"family": "Knudsen", "given": "Lene Surland", "initials": "LS"}, {"family": "M\u00f8ller", "given": "Anders", "initials": "A"}, {"family": "S\u00f8lling", "given": "Christoffer Grant", "initials": "CG"}, {"family": "Br\u00f8chner", "given": "Anne Craveiro", "initials": "AC"}, {"family": "Rasmussen", "given": "Bodil Steen", "initials": "BS", "orcid": "0000-0003-2190-145X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa66146077394afea60f71d4be6daf06.json"}}, {"family": "Nielsen", "given": "Henrik", "initials": "H"}, {"family": "Christensen", "given": "Steffen", "initials": "S"}, {"family": "Str\u00f8m", "given": "Thomas", "initials": "T"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Wahlin", "given": "Rebecka Rubenson", "initials": "RR"}, {"family": "Jakob", "given": "Stephan M", "initials": "SM"}, {"family": "Cioccari", "given": "Luca", "initials": "L"}, {"family": "Venkatesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Hammond", "given": "Naomi", "initials": "N"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Myatra", "given": "Sheila Nainan", "initials": "SN"}, {"family": "Jensen", "given": "Marie Qvist", "initials": "MQ"}, {"family": "Leistner", "given": "Jens Wolfgang", "initials": "JW"}, {"family": "Mikkelsen", "given": "Vibe Sommer", "initials": "VS", "orcid": "0000-0001-9518-0566", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e265103e395f42dba402abee098091bd.json"}}, {"family": "Svenningsen", "given": "Jens S", "initials": "JS"}, {"family": "Laursen", "given": "Signe Bj\u00f8rn", "initials": "SB"}, {"family": "Hatley", "given": "Emma Victoria", "initials": "EV"}, {"family": "Kristensen", "given": "Camilla Meno", "initials": "CM"}, {"family": "Al-Alak", "given": "Ali", "initials": "A"}, {"family": "Clapp", "given": "Esben", "initials": "E"}, {"family": "Jonassen", "given": "Trine Bak", "initials": "TB"}, {"family": "Bjerregaard", "given": "Caroline L\u00f8kke", "initials": "CL"}, {"family": "\u00d8sterby", "given": "Niels Christian Haubjerg", "initials": "NCH"}, {"family": "Jespersen", "given": "Mette Mindedahl", "initials": "MM"}, {"family": "Abou-Kassem", "given": "Dalia", "initials": "D"}, {"family": "Lassen", "given": "Mathilde Languille", "initials": "ML"}, {"family": "Zaabalawi", "given": "Reem", "initials": "R"}, {"family": "Daoud", "given": "Mohammed Mahmoud", "initials": "MM"}, {"family": "Abdi", "given": "Suhayb", "initials": "S"}, {"family": "Meier", "given": "Nick", "initials": "N"}, {"family": "la Cour", "given": "Kirstine", "initials": "K"}, {"family": "Derby", "given": "Cecilie Bauer", "initials": "CB"}, {"family": "Damlund", "given": "Birka Ravnholt", "initials": "BR"}, {"family": "Laigaard", "given": "Jens", "initials": "J"}, {"family": "Andersen", "given": "Lene Lund", "initials": "LL"}, {"family": "Mikkelsen", "given": "Johan", "initials": "J"}, {"family": "Jensen", "given": "Jeppe Lundholm Stadarfeld", "initials": "JLS", "orcid": "0000-0001-9247-8623", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/072014c0fcb84d5992707959e11dad7f.json"}}, {"family": "Rasmussen", "given": "Anders H\u00f8rby", "initials": "AH"}, {"family": "Arnerl\u00f6v", "given": "Emil", "initials": "E"}, {"family": "Lykke", "given": "Mathilde", "initials": "M"}, {"family": "Holst-Hansen", "given": "Mikkel Zacharias Bystrup", "initials": "MZB"}, {"family": "T\u00f8stesen", "given": "Boris Wied", "initials": "BW"}, {"family": "Schwab", "given": "Janne", "initials": "J"}, {"family": "Madsen", "given": "Emilie Kabel", "initials": "EK"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Lange", "given": "Theis", "initials": "T"}, {"family": "Perner", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": "65", "issue": "10", "pages": "1421-1430"}, "abstract": "In the early phase of the pandemic, some guidelines recommended the use of corticosteroids for critically ill patients with COVID-19, whereas others recommended against the use despite lack of firm evidence of either benefit or harm. In the COVID STEROID trial, we aimed to assess the effects of low-dose hydrocortisone on patient-centred outcomes in adults with COVID-19 and severe hypoxia.\n\nIn this multicentre, parallel-group, placebo-controlled, blinded, centrally randomised, stratified clinical trial, we randomly assigned adults with confirmed COVID-19 and severe hypoxia (use of mechanical ventilation or supplementary oxygen with a flow of at least 10 L/min) to either hydrocortisone (200 mg/d) vs a matching placebo for 7 days or until hospital discharge. The primary outcome was the number of days alive without life support at day 28 after randomisation.\n\nThe trial was terminated early when 30 out of 1000 participants had been enrolled because of external evidence indicating benefit from corticosteroids in severe COVID-19. At day 28, the median number of days alive without life support in the hydrocortisone vs placebo group were 7 vs 10 (adjusted mean difference: -1.1 days, 95% CI -9.5 to 7.3, P = .79); mortality was 6/16 vs 2/14; and the number of serious adverse reactions 1/16 vs 0/14.\n\nIn this trial of adults with COVID-19 and severe hypoxia, we were unable to provide precise estimates of the benefits and harms of hydrocortisone as compared with placebo as only 3% of the planned sample size were enrolled.\n\nClinicalTrials.gov: NCT04348305. European Union Drug Regulation Authorities Clinical Trials (EudraCT) Database: 2020-001395-15.", "doi": "10.1111/aas.13941", "pmid": "34138478", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8441888"}, {"db": "ClinicalTrials.gov", "key": "NCT04348305", "description": "European Union Drug Regulation Authorities Clinical Trials (EudraCT) Database: 2020-001395-15"}], "notes": [], "created": "2021-06-28T18:40:57.689Z", "modified": "2021-11-18T16:16:11.068Z"}, {"entity": "publication", "iuid": "dda5b431d9a64e4b8ed2ae8c5297c020", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dda5b431d9a64e4b8ed2ae8c5297c020.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dda5b431d9a64e4b8ed2ae8c5297c020"}}, "title": "Labor market effects of COVID-19 in Sweden and its neighbors: Evidence from administrative data.", "authors": [{"family": "Juranek", "given": "Steffen", "initials": "S"}, {"family": "Paetzold", "given": "J\u00f6rg", "initials": "J"}, {"family": "Winner", "given": "Hannes", "initials": "H"}, {"family": "Zoutman", "given": "Floris", "initials": "F"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Kyklos (Oxford)", "issn": "0023-5962", "issn-l": null, "volume": "74", "issue": "4", "pages": "512-526"}, "abstract": "This paper studies the labor market effects of non-pharmaceutical interventions (NPIs) to combat the COVID-19 pandemic. We focus on the Nordic countries which showed one of the highest variations in NPIs despite having similar community spread of COVID-19 at the onset of the pandemic: While Denmark, Finland and Norway imposed strict measures ('lockdowns'), Sweden decided for much lighter restrictions. Empirically, we use novel administrative data on weekly new unemployment and furlough spells from all 56 regions of the Nordic countries to compare the labor market outcomes of Sweden with the ones of its neighbors. Our evidence suggests that the labor markets of all countries were severely hit by the pandemic, although Sweden performed slightly better than its neighbors. Specifically, we find the worsening of the Swedish labor market to occur around 2 to 3 weeks later than in the other Nordic countries, and that its cumulative sum of new unemployment and furlough spells remained significantly lower (about 20-25%) during the time period of our study (up to week 21 of 2020).", "doi": "10.1111/kykl.12282", "pmid": "34908590", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "KYKL12282"}, {"db": "pmc", "key": "PMC8661996"}], "notes": [], "created": "2021-12-18T17:51:49.333Z", "modified": "2022-02-17T12:30:17.871Z"}, {"entity": "publication", "iuid": "0bd2b077da9d4a3091509a0596a30967", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0bd2b077da9d4a3091509a0596a30967.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0bd2b077da9d4a3091509a0596a30967"}}, "title": "How did micro-mobility change in response to COVID-19 pandemic? A case study based on spatial-temporal-semantic analytics", "authors": [{"family": "Li", "given": "Aoyong", "initials": "A", "orcid": "0000-0001-8032-5881", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a4e9267faa04311aafbfebc430a6852.json"}}, {"family": "Zhao", "given": "Pengxiang", "initials": "P"}, {"family": "Haitao", "given": "He", "initials": "H", "orcid": "0000-0002-6371-1358", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fcca1873da74684bda05ab77e5ee9a2.json"}}, {"family": "Mansourian", "given": "Ali", "initials": "A"}, {"family": "Axhausen", "given": "Kay W", "initials": "KW"}], "type": "journal-article", "published": "2021-11-00", "journal": {"title": "Computers, Environment and Urban Systems", "issn": "0198-9715", "volume": "90", "pages": "101703", "issn-l": null}, "abstract": null, "doi": "10.1016/j.compenvurbsys.2021.101703", "pmid": null, "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:52:03.764Z", "modified": "2021-10-11T17:52:03.891Z"}, {"entity": "publication", "iuid": "e050dfe1bcaa4bc998955d2a21416596", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e050dfe1bcaa4bc998955d2a21416596.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e050dfe1bcaa4bc998955d2a21416596"}}, "title": "Health and financial costs of adverse childhood experiences in 28 European countries: a systematic review and meta-analysis.", "authors": [{"family": "Hughes", "given": "Karen", "initials": "K"}, {"family": "Ford", "given": "Kat", "initials": "K"}, {"family": "Bellis", "given": "Mark A", "initials": "MA"}, {"family": "Glendinning", "given": "Freya", "initials": "F"}, {"family": "Harrison", "given": "Emma", "initials": "E"}, {"family": "Passmore", "given": "Jonathon", "initials": "J"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Lancet Public Health", "issn": "2468-2667", "volume": "6", "issue": "11", "pages": "e848-e857", "issn-l": null}, "abstract": "Adverse childhood experiences (ACEs) are associated with increased health risks across the life course. We aimed to estimate the annual health and financial burden of ACEs for 28 European countries.\n\nIn this systematic review and meta-analysis, we searched MEDLINE, CINAHL, PsycINFO, Applied Social Sciences Index and Abstracts, Criminal Justice Databases, and Education Resources Information Center for quantitative studies (published Jan 1, 1990, to Sept 8, 2020) that reported prevalence of ACEs and risks of health outcomes associated with ACEs. Pooled relative risks were calculated for associations between ACEs and harmful alcohol use, smoking, illicit drug use, high body-mass index, depression, anxiety, interpersonal violence, cancer, type 2 diabetes, cardiovascular disease, stroke, and respiratory disease. Country-level ACE prevalence was calculated using available data. Country-level population attributable fractions (PAFs) due to ACEs were generated and applied to 2019 estimates of disability-adjusted life-years. Financial costs (US$ in 2019) were estimated using an adapted human capital approach.\n\nIn most countries, interpersonal violence had the largest PAFs due to ACEs (range 14\u00b77-53\u00b75%), followed by harmful alcohol use (15\u00b77-45\u00b70%), illicit drug use (15\u00b72-44\u00b79%), and anxiety (13\u00b79%-44\u00b78%). Harmful alcohol use, smoking, and cancer had the highest ACE-attributable costs in many countries. Total ACE-attributable costs ranged from $0\u00b71 billion (Montenegro) to $129\u00b74 billion (Germany) and were equivalent to between 1\u00b71% (Sweden and Turkey) and 6\u00b70% (Ukraine) of nations' gross domestic products.\n\nAvailability of ACE data varies widely between countries and country-level estimates cannot be directly compared. However, findings suggest ACEs are associated with major health and financial costs across European countries. The cost of not investing to prevent ACEs must be recognised, particularly as countries look to recover from the COVID-19 pandemic, which interrupted services and education, and potentially increased risk factors for ACEs.\n\nWHO Regional Office for Europe.", "doi": "10.1016/S2468-2667(21)00232-2", "pmid": "34756168", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2468-2667(21)00232-2"}, {"db": "pmc", "key": "PMC8573710"}], "notes": [], "created": "2021-11-26T15:23:07.766Z", "modified": "2021-11-26T15:23:07.780Z"}, {"entity": "publication", "iuid": "a6de81647b9d48ff81db31a531c34ff8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6de81647b9d48ff81db31a531c34ff8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6de81647b9d48ff81db31a531c34ff8"}}, "title": "Evolutionary analysis of the Delta and Delta Plus variants of the SARS-CoV-2 viruses.", "authors": [{"family": "Kannan", "given": "Saathvik R", "initials": "SR"}, {"family": "Spratt", "given": "Austin N", "initials": "AN"}, {"family": "Cohen", "given": "Alisha R", "initials": "AR"}, {"family": "Naqvi", "given": "S Hasan", "initials": "SH"}, {"family": "Chand", "given": "Hitendra S", "initials": "HS"}, {"family": "Quinn", "given": "Thomas P", "initials": "TP"}, {"family": "Lorson", "given": "Christian L", "initials": "CL"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}, {"family": "Singh", "given": "Kamal", "initials": "K"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "J Autoimmun", "issn": "1095-9157", "volume": "124", "pages": "102715", "issn-l": null}, "abstract": "Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been rapidly evolving in the form of new variants. At least eleven known variants have been reported. The objective of this study was to delineate the differences in the mutational profile of Delta and Delta Plus variants. High-quality sequences (n = 1756) of Delta (B.1.617.2) and Delta Plus (AY.1 or B.1.617.2.1) variants were used to determine the prevalence of mutations (\u226520 %) in the entire SARS-CoV-2 genome, their co-existence, and change in prevalence over a period of time. Structural analysis was conducted to get insights into the impact of mutations on antibody binding. A Sankey diagram was generated using phylogenetic analysis coupled with sequence-acquisition dates to infer the migration of the Delta Plus variant and its presence in the United States. The Delta Plus variant had a significant number of high-prevalence mutations (\u226520 %) than in the Delta variant. Signature mutations in Spike (G142D, A222V, and T95I) existed at a more significant percentage in the Delta Plus variant than the Delta variant. Three mutations in Spike (K417N, V70F, and W258L) were exclusively present in the Delta Plus variant. A new mutation was identified in ORF1a (A1146T), which was only present in the Delta Plus variant with ~58 % prevalence. Furthermore, five key mutations (T95I, A222V, G142D, R158G, and K417N) were significantly more prevalent in the Delta Plus than in the Delta variant. Structural analyses revealed that mutations alter the sidechain conformation to weaken the interactions with antibodies. Delta Plus, which first emerged in India, reached the United States through England and Japan, followed by its spread to more than 20 the United States. Based on the results presented here, it is clear that the Delta and Delta Plus variants have unique mutation profiles, and the Delta Plus variant is not just a simple addition of K417N to the Delta variant. Highly correlated mutations may have emerged to keep the structural integrity of the virus.", "doi": "10.1016/j.jaut.2021.102715", "pmid": "34399188", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8354793"}, {"db": "pii", "key": "S0896-8411(21)00123-2"}], "notes": [], "created": "2021-08-17T06:35:35.248Z", "modified": "2023-01-13T14:45:01.860Z"}, {"entity": "publication", "iuid": "45243b8fa33a46138df138172a5df835", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/45243b8fa33a46138df138172a5df835.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/45243b8fa33a46138df138172a5df835"}}, "title": "Estimated number of deaths directly averted in people 60 years and older as a result of COVID-19 vaccination in the WHO European Region, December 2020 to November 2021.", "authors": [{"family": "Mesl\u00e9", "given": "Margaux Mi", "initials": "MM"}, {"family": "Brown", "given": "Jeremy", "initials": "J"}, {"family": "Mook", "given": "Piers", "initials": "P"}, {"family": "Hagan", "given": "Jos\u00e9", "initials": "J"}, {"family": "Pastore", "given": "Roberta", "initials": "R"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Spiteri", "given": "Gianfranco", "initials": "G"}, {"family": "Ravasi", "given": "Giovanni", "initials": "G"}, {"family": "Nicolay", "given": "Nathalie", "initials": "N"}, {"family": "Andrews", "given": "Nick", "initials": "N"}, {"family": "Dykhanovska", "given": "Tetiana", "initials": "T"}, {"family": "Mossong", "given": "Jo\u00ebl", "initials": "J"}, {"family": "Sadkowska-Todys", "given": "Ma\u0142gorzata", "initials": "M"}, {"family": "Nikiforova", "given": "Raina", "initials": "R"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}, {"family": "Mazagatos", "given": "Clara", "initials": "C"}, {"family": "Kyncl", "given": "Jan", "initials": "J"}, {"family": "McMenamin", "given": "Jim", "initials": "J"}, {"family": "Melillo", "given": "Tanya", "initials": "T"}, {"family": "Kaoustou", "given": "Stella", "initials": "S"}, {"family": "L\u00e9vy-Bruhl", "given": "Daniel", "initials": "D"}, {"family": "Haarhuis", "given": "Freek", "initials": "F"}, {"family": "Rich", "given": "Rivka", "initials": "R"}, {"family": "Kall", "given": "Meaghan", "initials": "M"}, {"family": "Nitzan", "given": "Dorit", "initials": "D"}, {"family": "Smallwood", "given": "Catherine", "initials": "C"}, {"family": "Pebody", "given": "Richard G", "initials": "RG"}], "type": "journal article", "published": "2021-11-00", "journal": {"issn": "1560-7917", "volume": "26", "issue": "47", "title": "Euro Surveill", "issn-l": null}, "abstract": "Since December 2019, over 1.5 million SARS-CoV-2-related fatalities have been recorded in the World Health Organization European Region - 90.2% in people \u2265 60 years. We calculated lives saved in this age group by COVID-19 vaccination in 33 countries from December 2020 to November 2021, using weekly reported deaths and vaccination coverage. We estimated that vaccination averted 469,186 deaths (51% of 911,302 expected deaths; sensitivity range: 129,851-733,744; 23-62%). Impact by country ranged 6-93%, largest when implementation was early.", "doi": "10.2807/1560-7917.ES.2021.26.47.2101021", "pmid": "34823641", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8619871"}], "notes": [], "created": "2021-11-26T13:03:12.068Z", "modified": "2021-12-18T18:20:10.012Z"}, {"entity": "publication", "iuid": "729c6621d33d4b269c6ce37008c4ae81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/729c6621d33d4b269c6ce37008c4ae81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/729c6621d33d4b269c6ce37008c4ae81"}}, "title": "Epidemiological comparison of the first and second waves of the COVID-19 pandemic in Nigeria, February 2020-April 2021.", "authors": [{"family": "Akande", "given": "Oluwatosin Wuraola", "initials": "OW", "orcid": "0000-0001-6906-895X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7ce51eb7a0b4a04b6af2802c88e2290.json"}}, {"family": "Elimian", "given": "Kelly Osezele", "initials": "KO", "orcid": "0000-0003-2729-1613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/695dddf720414c3585d35b30184f0178.json"}}, {"family": "Igumbor", "given": "Ehimario", "initials": "E", "orcid": "0000-0002-6313-6031", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff090388bcf945529573cefac01ec72d.json"}}, {"family": "Dunkwu", "given": "Lauryn", "initials": "L"}, {"family": "Kaduru", "given": "Chijioke", "initials": "C"}, {"family": "Olopha", "given": "Olubunmi Omowunmi", "initials": "OO"}, {"family": "Ohanu", "given": "Dabri Olohije", "initials": "DO"}, {"family": "Nwozor", "given": "Lilian", "initials": "L"}, {"family": "Agogo", "given": "Emmanuel", "initials": "E"}, {"family": "Aruna", "given": "Olusola", "initials": "O"}, {"family": "Balogun", "given": "Muhammad Shakir", "initials": "MS"}, {"family": "Aderinola", "given": "Olaolu", "initials": "O"}, {"family": "Ahumibe", "given": "Anthony", "initials": "A"}, {"family": "Arinze", "given": "Chinedu", "initials": "C"}, {"family": "Badaru", "given": "Sikiru Olanrewaju", "initials": "SO"}, {"family": "Nwachukwu", "given": "William", "initials": "W"}, {"family": "Dada", "given": "Augustine Olajide", "initials": "AO"}, {"family": "Erameh", "given": "Cyril", "initials": "C"}, {"family": "Hamza", "given": "Khadeejah", "initials": "K"}, {"family": "Mohammed", "given": "Tarik Benjamin", "initials": "TB"}, {"family": "Ndodo", "given": "Nnaemeka", "initials": "N"}, {"family": "Obiekea", "given": "Celestina", "initials": "C"}, {"family": "Ofoegbunam", "given": "Chinenye", "initials": "C"}, {"family": "Ogunbode", "given": "Oladipo", "initials": "O"}, {"family": "Ohonsi", "given": "Cornelius", "initials": "C"}, {"family": "Tobin", "given": "Ekaete Alice", "initials": "EA", "orcid": "0000-0001-5059-807X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b9b83f10c75414db97e06c515b1ef8d.json"}}, {"family": "Yashe", "given": "Rimamdeyati", "initials": "R"}, {"family": "Adekaiyaoja", "given": "Afolabi", "initials": "A"}, {"family": "Asuzu", "given": "Michael C", "initials": "MC"}, {"family": "Audu", "given": "Rosemary Ajuma", "initials": "RA"}, {"family": "Bello", "given": "Muhammad Bashir", "initials": "MB"}, {"family": "Bello", "given": "Shaibu Oricha", "initials": "SO"}, {"family": "Deeni", "given": "Yusuf Yahaya", "initials": "YY"}, {"family": "Disu", "given": "Yahya", "initials": "Y"}, {"family": "Joseph", "given": "Gbenga", "initials": "G"}, {"family": "Ezeokafor", "given": "Chidiebere", "initials": "C"}, {"family": "Habib", "given": "Zaiyad Garba", "initials": "ZG"}, {"family": "Ibeh", "given": "Christian", "initials": "C"}, {"family": "Ike", "given": "Ifeanyi Franklin", "initials": "IF"}, {"family": "Iwara", "given": "Emem", "initials": "E"}, {"family": "Luka-Lawal", "given": "Rejoice Kudirat", "initials": "RK"}, {"family": "Namara", "given": "Geoffrey", "initials": "G"}, {"family": "Okwor", "given": "Tochi", "initials": "T"}, {"family": "Olajide", "given": "Lois", "initials": "L"}, {"family": "Ilesanmi", "given": "Oluwafunke Olufemi", "initials": "OO"}, {"family": "Omonigho", "given": "Solomon", "initials": "S"}, {"family": "Oyiri", "given": "Ferdinand", "initials": "F"}, {"family": "Takpa", "given": "Koubagnine", "initials": "K"}, {"family": "Ugbogulu", "given": "Nkem Usha", "initials": "NU"}, {"family": "Ibekwe", "given": "Priscilla", "initials": "P"}, {"family": "Oladejo", "given": "John", "initials": "J"}, {"family": "Ilori", "given": "Elsie", "initials": "E"}, {"family": "Ochu", "given": "Chinwe Lucia", "initials": "CL", "orcid": "0000-0002-0630-7332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f390fa99a654ff899f5e9df6fbaf88e.json"}}, {"family": "Ihekweazu", "given": "Chikwe", "initials": "C"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "11", "issn-l": "2059-7908"}, "abstract": "With reports of surges in COVID-19 case numbers across over 50 countries, country-level epidemiological analysis is required to inform context-appropriate response strategies for containment and mitigation of the outbreak. We aimed to compare the epidemiological features of the first and second waves of COVID-19 in Nigeria.\n\nWe conducted a retrospective analysis of the Surveillance Outbreak Response Management and Analysis System data of the first and second epidemiological waves, which were between 27 February and 24 October 2020, and 25 October 2020 to 3 April 2021, respectively. Descriptive statistical measures including frequencies and percentages, test positivity rate (TPR), cumulative incidence (CI) and case fatality rates (CFRs) were compared. A p value of <0.05 was considered statistically significant. All statistical analyses were carried out in STATA V.13.\n\nThere were 802 143 tests recorded during the study period (362 550 and 439 593 in the first and second waves, respectively). Of these, 66 121 (18.2%) and 91 644 (20.8%) tested positive in the first and second waves, respectively. There was a 21.3% increase in the number of tests conducted in the second wave with TPR increasing by 14.3%. CI during the first and second waves were 30.3/100 000 and 42.0/100 000 respectively. During the second wave, confirmed COVID-19 cases increased among females and people 30 years old or younger and decreased among urban residents and individuals with travel history within 14 days of sample collection (p value <0.001). Most confirmed cases were asymptomatic at diagnosis during both waves: 74.9% in the first wave; 79.7% in the second wave. CFR decreased during the second wave (0.7%) compared with the first wave (1.8%).\n\nNigeria experienced a larger but less severe second wave of COVID-19. Continued implementation of public health and social measures is needed to mitigate the resurgence of another wave.", "doi": "10.1136/bmjgh-2021-007076", "pmid": "34794956", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-007076"}, {"db": "pmc", "key": "PMC8602923"}], "notes": [], "created": "2021-11-26T14:09:34.010Z", "modified": "2021-11-26T14:09:34.139Z"}, {"entity": "publication", "iuid": "31f4a05cc65c4d73a38ca74b9fc9f02f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/31f4a05cc65c4d73a38ca74b9fc9f02f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/31f4a05cc65c4d73a38ca74b9fc9f02f"}}, "title": "Decrease in community antibiotic consumption during the COVID-19 pandemic, EU/EEA, 2020.", "authors": [{"family": "H\u00f6gberg", "given": "Liselotte Diaz", "initials": "LD"}, {"family": "Vlahovi\u0107-Pal\u010devski", "given": "Vera", "initials": "V"}, {"family": "Pereira", "given": "C\u00e1tia", "initials": "C"}, {"family": "Weist", "given": "Klaus", "initials": "K"}, {"family": "Monnet", "given": "Dominique L", "initials": "DL"}, {"family": "ESAC-Net study group", "given": "", "initials": ""}, {"family": "ESAC-Net study group participants", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "46", "issn-l": null}, "abstract": "We present a European Union/European Economic Area-wide overview of the changes in consumption of antibacterials for systemic use (ATC J01) in the community between 2019 and 2020 as reported to the European Surveillance of Antimicrobial Consumption Network. Overall antibiotic consumption decreased by 18.3% between 2019 and 2020, the largest annual decrease in the network's two-decade history. We observed a strong association between the level of community antibiotic consumption in 2019 and the size of the decrease between 2019 and 2020.", "doi": "10.2807/1560-7917.ES.2021.26.46.2101020", "pmid": "34794534", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T14:09:52.886Z", "modified": "2021-11-26T14:09:52.901Z"}, {"entity": "publication", "iuid": "a46b973999d8441ca28db616716d9418", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a46b973999d8441ca28db616716d9418.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a46b973999d8441ca28db616716d9418"}}, "title": "Beyond building back better: imagining a future for human and planetary health.", "authors": [{"family": "de Le\u00f3n", "given": "Emilia Arag\u00f3n", "initials": "EA"}, {"family": "Shriwise", "given": "Amanda", "initials": "A"}, {"family": "Tomson", "given": "G\u00d6ran", "initials": "G"}, {"family": "Morton", "given": "Stephen", "initials": "S"}, {"family": "Lemos", "given": "Diogo Sim\u00e3o", "initials": "DS"}, {"family": "Menne", "given": "Bettina", "initials": "B"}, {"family": "Dooris", "given": "Mark", "initials": "M"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Lancet Planet Health", "issn": "2542-5196", "volume": "5", "issue": "11", "pages": "e827-e839", "issn-l": null}, "abstract": "COVID-19 is disrupting and transforming the world. We argue that transformations catalysed by this pandemic should be used to improve human and planetary health and wellbeing. This paradigm shift requires decision makers and policy makers to go beyond building back better, by nesting the economic domain of sustainable development within social and environmental domains. Drawing on the engage, assess, align, accelerate, and account (E4As) approach to implementing the 2030 Agenda for Sustainable Development, we explore the implications of this kind of radical transformative change, focusing particularly on the role of the health sector. We conclude that a recovery and transition from the COVID-19 pandemic that delivers the future humanity wants and needs requires more than a technical understanding of the transformation at hand. It also requires commitment and courage from leaders and policy makers to challenge dominant constructs and to work towards a truly thriving, equitable, and sustainable future to create a world where economic development is not an end goal itself, but a means to secure the health and wellbeing of people and the planet.", "doi": "10.1016/S2542-5196(21)00262-X", "pmid": "34774123", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2542-5196(21)00262-X"}, {"db": "pmc", "key": "PMC8600369"}], "notes": [], "created": "2021-11-26T14:29:59.933Z", "modified": "2021-11-26T14:50:38.618Z"}, {"entity": "publication", "iuid": "5c9dac66360b4cf9963f4ccc473e1a37", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c9dac66360b4cf9963f4ccc473e1a37.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c9dac66360b4cf9963f4ccc473e1a37"}}, "title": "Allergen Immunotherapy management during vaccinations: An international survey.", "authors": [{"family": "Masieri", "given": "Simonetta", "initials": "S"}, {"family": "Bachert", "given": "Claus", "initials": "C"}, {"family": "Ojeda", "given": "Pedro", "initials": "P"}, {"family": "Kim", "given": "Chang-Keun", "initials": "CK"}, {"family": "Carlo", "given": "Cavaliere", "initials": "C"}, {"family": "Giorgio", "given": "Ciprandi", "initials": "C"}, {"family": "Study Group on AIT & Vaccinations", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "World Allergy Organ J", "issn": "1939-4551", "volume": "14", "issue": "11", "pages": "100601", "issn-l": "1939-4551"}, "abstract": "Vaccination against viral and bacterial pathogens represents a challenging issue in allergic subjects, mainly concerning patients undergoing allergen immunotherapy (AIT). For this reason, an international survey has been performed involving a panel of experts who responded to a series of questions, also concerning the COVID-19 impact on allergen immunotherapy and vaccinations. The results showed that co-administration of vaccines and AIT requires caution, mainly during the pandemic era. Moreover, the choice of AIT product should be oriented considering also the safety profile.", "doi": "10.1016/j.waojou.2021.100601", "pmid": "34777679", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1939-4551(21)00095-8"}, {"db": "pmc", "key": "PMC8575483"}], "notes": [], "created": "2021-11-26T14:25:04.676Z", "modified": "2021-11-26T14:25:04.693Z"}, {"entity": "publication", "iuid": "398f1033a4704b8c8d3fee900804eaba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/398f1033a4704b8c8d3fee900804eaba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/398f1033a4704b8c8d3fee900804eaba"}}, "title": "Flexibility during the COVID-19 Pandemic Response: Healthcare Facility Assessment Tools for Resilient Evaluation.", "authors": [{"family": "Brambilla", "given": "Andrea", "initials": "A", "orcid": "0000-0001-7891-0336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24f99c1c49954fd9a1806ce9641c1dce.json"}}, {"family": "Sun", "given": "Tian-Zhi", "initials": "TZ"}, {"family": "Elshazly", "given": "Waleed", "initials": "W"}, {"family": "Ghazy", "given": "Ahmed", "initials": "A"}, {"family": "Barach", "given": "Paul", "initials": "P"}, {"family": "Lindahl", "given": "G\u00f6ran", "initials": "G"}, {"family": "Capolongo", "given": "Stefano", "initials": "S"}], "type": "journal article", "published": "2021-10-31", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "21", "issn-l": null}, "abstract": "Healthcare facilities are facing huge challenges due to the outbreak of COVID-19. Around the world, national healthcare contingency plans have struggled to cope with the population health impact of COVID-19, with healthcare facilities and critical care systems buckling under the extraordinary pressures. COVID-19 has starkly highlighted the lack of reliable operational tools for assessing the level sof flexibility of a hospital building to support strategic and agile decision making. The aim of this study was to modify, improve and test an existing assessment tool for evaluating hospital facilities flexibility and resilience. We followed a five-step process for collecting data by (i) doing a literature review about flexibility principles and strategies, (ii) reviewing healthcare design guidelines, (iii) examining international healthcare facilities case studies, (iv) conducting a critical review and optimization of the existing tool, and (v) assessing the usability of the evaluation tool. The new version of the OFAT framework (Optimized Flexibility Assessment Tool) is composed of nine evaluation parameters and subdivided into measurable variables with scores ranging from 0 to 10. The pilot testing of case studies enabled the assessment and verification the OFAT validity and reliability in support of decision makers in addressing flexibility of hospital design and/or operations. Healthcare buildings need to be designed and built based on principles of flexibility to accommodate current healthcare operations, adapting to time-sensitive physical transformations and responding to contemporary and future public health emergencies.", "doi": "10.3390/ijerph182111478", "pmid": "34769993", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijerph182111478"}, {"db": "pmc", "key": "PMC8583089"}], "notes": [], "created": "2021-11-26T15:08:47.801Z", "modified": "2021-11-26T15:08:47.858Z"}, {"entity": "publication", "iuid": "9aa3eb392c194c629eb50d77a4876866", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9aa3eb392c194c629eb50d77a4876866.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9aa3eb392c194c629eb50d77a4876866"}}, "title": "Cardiovascular events and safety outcomes associated with remdesivir using a World Health Organization international pharmacovigilance database.", "authors": [{"family": "Jung", "given": "Se Yong", "initials": "SY", "orcid": "0000-0003-1337-563X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e77bcc25ff234e30b8b5b67aab7dc06f.json"}}, {"family": "Kim", "given": "Min Seo", "initials": "MS"}, {"family": "Li", "given": "Han", "initials": "H"}, {"family": "Lee", "given": "Keum Hwa", "initials": "KH", "orcid": "0000-0002-1511-9587", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f05874950d04389af6deb3a0067b914.json"}}, {"family": "Koyanagi", "given": "Ai", "initials": "A", "orcid": "0000-0002-9565-5004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ed135d1694d4ec9858491cfbcba065d.json"}}, {"family": "Solmi", "given": "Marco", "initials": "M"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A", "orcid": "0000-0002-2945-2946", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9e0f16d2f4a444c82a37156bcf3f1b4.json"}}, {"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Tizaoui", "given": "Kalthoum", "initials": "K"}, {"family": "Cargnin", "given": "Sarah", "initials": "S"}, {"family": "Terrazzino", "given": "Salvatore", "initials": "S", "orcid": "0000-0002-4909-1121", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/643fa55ffcdb43fb90bad571f8c0e121.json"}}, {"family": "Hong", "given": "Sung Hwi", "initials": "SH"}, {"family": "Abou Ghayda", "given": "Ramy", "initials": "R"}, {"family": "Kim", "given": "Nam Kyun", "initials": "NK"}, {"family": "Chung", "given": "Seo Kyoung", "initials": "SK"}, {"family": "Jacob", "given": "Louis", "initials": "L", "orcid": "0000-0003-1071-1239", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f59bc7c0941a462aa7426d8e2a995b30.json"}}, {"family": "Salem", "given": "Joe-Elie", "initials": "JE", "orcid": "0000-0002-0331-3307", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48ca28bff1864378845333f93c6926f8.json"}}, {"family": "Yon", "given": "Dong Keon", "initials": "DK", "orcid": "0000-0003-1628-9948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/747eb5856d2e444fbc1e5aaef8d3aa40.json"}}, {"family": "Lee", "given": "Seung Won", "initials": "SW", "orcid": "0000-0001-5632-5208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b38b67e00dbf4d80a72a30152b99c0a3.json"}}, {"family": "Kostev", "given": "Karel", "initials": "K"}, {"family": "Kim", "given": "Ah Young", "initials": "AY"}, {"family": "Jung", "given": "Jo Won", "initials": "JW"}, {"family": "Choi", "given": "Jae Young", "initials": "JY"}, {"family": "Shin", "given": "Jin Soo", "initials": "JS"}, {"family": "Park", "given": "Soon-Jung", "initials": "SJ"}, {"family": "Choi", "given": "Seong Woo", "initials": "SW"}, {"family": "Ban", "given": "Kiwon", "initials": "K"}, {"family": "Moon", "given": "Sung-Hwan", "initials": "SH"}, {"family": "Go", "given": "Yun Young", "initials": "YY"}, {"family": "Shin", "given": "Jae Il", "initials": "JI", "orcid": "0000-0003-2326-1820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ca450cb43e3478d81ba93be745f0ea0.json"}}, {"family": "Smith", "given": "Lee", "initials": "L"}], "type": "journal article", "published": "2021-10-31", "journal": {"title": "Clin Transl Sci", "issn": "1752-8062", "issn-l": "1752-8054"}, "abstract": "On October 2020, the US Food and Drug Administration (FDA) approved remdesivir as the first drug for the treatment of coronavirus disease 2019 (COVID-19), increasing remdesivir prescriptions worldwide. However, potential cardiovascular (CV) toxicities associated with remdesivir remain unknown. We aimed to characterize the CV adverse drug reactions (ADRs) associated with remdesivir using VigiBase, an individual case safety report database of the World Health Organization (WHO). Disproportionality analyses of CV-ADRs associated with remdesivir were performed using reported odds ratios and information components. We conducted in vitro experiments using cardiomyocytes derived from human pluripotent stem cell cardiomyocytes (hPSC-CMs) to confirm cardiotoxicity of remdesivir. To distinguish drug-induced CV-ADRs from COVID-19 effects, we restricted analyses to patients with COVID-19 and found that, after adjusting for multiple confounders, cardiac arrest (adjusted odds ratio [aOR]: 1.88, 95% confidence interval [CI]: 1.08-3.29), bradycardia (aOR: 2.09, 95% CI: 1.24-3.53), and hypotension (aOR: 1.67, 95% CI: 1.03-2.73) were associated with remdesivir. In vitro data demonstrated that remdesivir reduced the cell viability of hPSC-CMs in time- and dose-dependent manners. Physicians should be aware of potential CV consequences following remdesivir use and implement adequate CV monitoring to maintain a tolerable safety margin.", "doi": "10.1111/cts.13168", "pmid": "34719115", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:54:53.842Z", "modified": "2021-11-01T19:54:54.146Z"}, {"entity": "publication", "iuid": "f011d680507b424ca14ca9eda9d3eb7b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f011d680507b424ca14ca9eda9d3eb7b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f011d680507b424ca14ca9eda9d3eb7b"}}, "title": "Stockpiling and food worries: Changing habits and choices in the midst of COVID-19 pandemic.", "authors": [{"family": "Amuakwa-Mensah", "given": "Franklin", "initials": "F"}, {"family": "Amuakwa-Mensah", "given": "Salome", "initials": "S"}, {"family": "Klege", "given": "Rebecca Afua", "initials": "RA"}, {"family": "Adom", "given": "Philip Kofi", "initials": "PK"}], "type": "journal article", "published": "2021-10-30", "journal": {"title": "Socioecon Plann Sci", "issn": "0038-0121", "pages": "101181", "issn-l": null}, "abstract": "Albeit, governments have instituted strong containment measures in the wake of the COVID-19 pandemic, concerns of continuous local spread and economic impact of the virus are impacting global food chains and food security. This paper investigates the effect of concern about the i) local spread and ii) economic impact of COVID-19, on the change in the amount of food and necessities bought in twelve Sub-Sahara African countries. In addition, we examine if these effects are channeled through food worries. The study uses a unique survey dataset by GeoPoll collected in April 2020 (first round) and May 2020 (second round) and employs a multinomial logit and generalized structural equation models. We find significant effect of concern about COVID-19 on change in the package size of food and necessities bought, which is heterogeneous across gender group and rural-urban divide. Our results reveal that concerns of COVID-19 might be promoting stockpiling behavior among females and those with no food worries (due to having sufficient money or resources). This if not properly managed could in the medium to long-term affect the food supply chain, food waste and exacerbate food worries problem especially for already food deprived homes. We discuss the policy implications.", "doi": "10.1016/j.seps.2021.101181", "pmid": "34744190", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0038-0121(21)00173-7"}, {"db": "pmc", "key": "PMC8562977"}], "notes": [], "created": "2021-11-26T15:36:31.982Z", "modified": "2021-11-26T15:36:32.016Z"}, {"entity": "publication", "iuid": "f6aa34deb2484c9cab3553f51015f89d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6aa34deb2484c9cab3553f51015f89d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6aa34deb2484c9cab3553f51015f89d"}}, "title": "Quality of Life, Needs and Fears of Mothers of Children with Disabilities in Saudi Arabia during the COVID-19 Lockdown.", "authors": [{"family": "Al Awaji", "given": "Nisreen", "initials": "N"}, {"family": "Aldhahi", "given": "Monira", "initials": "M", "orcid": "0000-0002-5255-4860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a3b7b4eb7d6440da62df1e4d091329b.json"}}, {"family": "Akil", "given": "Shahnaz", "initials": "S", "orcid": "0000-0002-3256-4543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c031d893b12b4c4ca8cbb330a89384d0.json"}}, {"family": "Awad", "given": "Salwa", "initials": "S"}, {"family": "Mortada", "given": "Eman", "initials": "E"}], "type": "journal article", "published": "2021-10-30", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "21", "pages": null}, "abstract": "Substantial changes in life dynamics resulting from the outbreak of the coronavirus disease 2019 (COVID-19) could have an impact on the quality of life (QoL) of mothers of children with and without disabilities. This study compared the quality of life (QoL) of mothers of children with disabilities (MCD) to the QoL of mothers of children without disabilities (CON) in Saudi Arabia during COVID-19 lockdown. It explored mothers' concerns and the type of support they need during the quarantine. A comparative cross-sectional study was conducted during the lockdown. An online questionnaire was distributed to mothers raising children with and without disabilities in Saudi Arabia. A total of 340 mothers participated in the study by completing the survey: 93 MCD and 247 CON. The QoL of MCD and CON was assessed using the WHOQOL-BREF questionnaire. Furthermore, detailed information was provided by the mothers regarding their needs and concerns during the lockdown. The results of the study revealed that the overall QoL was significantly higher in the CON group, compared to the MCD group, during the COVID-19 lockdown. The social well-being and environmental well-being reported by MCD were significantly lower on the total scale of the WHOQOL-BREF than those reported by the CON group. The comparison between the two groups revealed significant differences in the support required by mothers during the COVID-19 pandemic: a higher percentage of MCD needed emotional and psychological support, especially from family members. The major concerns reported by MCD were the deterioration of their children's medical conditions and the lack of medical supplies during the lockdown.", "doi": "10.3390/ijerph182111442", "pmid": "34769958", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182111442"}, {"db": "pmc", "key": "PMC8583177"}], "notes": [], "created": "2021-11-26T15:09:15.845Z", "modified": "2022-02-17T12:28:28.363Z"}, {"entity": "publication", "iuid": "6c6a0d8aa3044e1d85c5d613e6374d85", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c6a0d8aa3044e1d85c5d613e6374d85.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c6a0d8aa3044e1d85c5d613e6374d85"}}, "title": "On the brink of disruption: Applying Resilience Engineering to anticipate system performance under crisis.", "authors": [{"family": "Arcuri", "given": "Rodrigo", "initials": "R"}, {"family": "Bellas", "given": "Hugo Cesar", "initials": "HC"}, {"family": "Ferreira", "given": "Denise de Souza", "initials": "DS"}, {"family": "Bulh\u00f5es", "given": "B\u00e1rbara", "initials": "B"}, {"family": "Vidal", "given": "Mario Cesar Rodr\u00edguez", "initials": "MCR"}, {"family": "Carvalho", "given": "Paulo Victor Rodrigues de", "initials": "PVR"}, {"family": "Jatob\u00e1", "given": "Alessandro", "initials": "A"}, {"family": "Hollnagel", "given": "Erik", "initials": "E"}], "type": "journal article", "published": "2021-10-30", "journal": {"title": "Appl Ergon", "issn": "1872-9126", "volume": "99", "pages": "103632", "issn-l": null}, "abstract": "As COVID-19 spread across Brazil, it quickly reached remote regions including Amazon's ultra-peripheral locations where patient transportation through rivers is added to the list of obstacles to overcome. This article analyses the pandemic's effects in the access of riverine communities to the prehospital emergency healthcare system in the Brazilian Upper Amazon River region. To do so, we present two studies that by using a Resilience Engineering approach aimed to predict the functioning of the Brazilian Mobile Emergency Medical Service (SAMU) for riverside and coastal areas during the COVID-19 pandemic, based on the normal system functioning. Study I, carried out before the pandemic, applied ethnographic methods for data collection and the Functional Resonance Analysis Method - FRAM for data analysis in order to develop a model of the mobile emergency care in the region during typical conditions of operation. Study II then estimated how changes in variability dynamics would alter system functioning during the pandemic, arriving at three trends that could lead the service to collapse. Finally, the accuracy of predictions is discussed after the pandemic first peaked in the region. Findings reveal that relatively small changes in variability dynamics can deliver strong implications to operating care and safety of expeditions aboard water ambulances. Also, important elements that add to the resilient capabilities of the system are extra-organizational, and thus during the pandemic safety became jeopardized as informal support networks grew fragile. Using FRAM for modelling regular operation enabled prospective scenario analysis that accurately predicted disruptions in providing emergency care to riverine population.", "doi": "10.1016/j.apergo.2021.103632", "pmid": "34740073", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0003-6870(21)00279-9"}, {"db": "pmc", "key": "PMC8557093"}], "notes": [], "created": "2021-11-08T09:20:43.862Z", "modified": "2021-11-08T09:20:43.899Z"}, {"entity": "publication", "iuid": "ac08bcfa36fc43cdab597875f30bf61d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac08bcfa36fc43cdab597875f30bf61d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac08bcfa36fc43cdab597875f30bf61d"}}, "title": "Circulating levels of calprotectin, a signature of neutrophil activation in prediction of severe respiratory failure in COVID-19 patients: a multicenter, prospective study (CalCov study).", "authors": [{"family": "Garc\u00eda de Guadiana-Romualdo", "given": "Luis", "initials": "L", "orcid": "0000-0003-3028-3198", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2733220d3ab54ff5adb9fe765ee033a8.json"}}, {"family": "Rodr\u00edguez Rojas", "given": "Carlos", "initials": "C"}, {"family": "Morell-Garc\u00eda", "given": "Daniel", "initials": "D"}, {"family": "Andaluz-Ojeda", "given": "David", "initials": "D"}, {"family": "Rodr\u00edguez Mulero", "given": "Mar\u00eda Dolores", "initials": "MD"}, {"family": "Rodr\u00edguez-Borja", "given": "Enrique", "initials": "E"}, {"family": "Ballesteros-Vizoso", "given": "Antonieta", "initials": "A"}, {"family": "Calvo", "given": "Mar\u00eda Dolores", "initials": "MD"}, {"family": "Albert-Botella", "given": "Lourdes", "initials": "L"}, {"family": "Pozo Gir\u00e1ldez", "given": "Adela", "initials": "A"}, {"family": "Llompart-Alabern", "given": "Isabel", "initials": "I"}, {"family": "Bolado Jim\u00e9nez", "given": "Cristina", "initials": "C"}, {"family": "Hern\u00e1ndez Olivo", "given": "Marta", "initials": "M"}, {"family": "Fern\u00e1ndez Presa", "given": "Luc\u00eda", "initials": "L"}, {"family": "Ortega-P\u00e9rez", "given": "Juan", "initials": "J"}, {"family": "Fora Romero", "given": "Mar\u00eda Jos\u00e9", "initials": "MJ"}, {"family": "Campos-Rodr\u00edguez", "given": "Valerio", "initials": "V"}, {"family": "Ballester F\u00e9rriz", "given": "Andrea", "initials": "A"}, {"family": "Guiu-Mart\u00ed", "given": "Alexandra M", "initials": "AM"}, {"family": "Pinilla Arribas", "given": "Leyre", "initials": "L"}, {"family": "Galindo Mart\u00ednez", "given": "Mar\u00eda", "initials": "M"}, {"family": "Puerto-Lara", "given": "Edwin R", "initials": "ER"}, {"family": "L\u00f3pez Tarazaga", "given": "Ana Belen", "initials": "AB"}, {"family": "Ros Braquehais", "given": "Mar\u00eda Salom\u00e9", "initials": "MS"}, {"family": "Nogales Mart\u00edn", "given": "Leonor", "initials": "L"}, {"family": "Juez Santamar\u00eda", "given": "Celia", "initials": "C"}, {"family": "Trapiello Fern\u00e1ndez", "given": "Wysalli", "initials": "W"}, {"family": "Espinilla Fern\u00e1ndez", "given": "Virginia", "initials": "V"}, {"family": "Havelka", "given": "Aleksandra", "initials": "A"}, {"family": "Albaladejo-Ot\u00f3n", "given": "Mar\u00eda Dolores", "initials": "MD"}], "type": "journal article", "published": "2021-10-30", "journal": {"title": "Inflamm Res", "issn": "1420-908X", "issn-l": null}, "abstract": "Severe COVID-19 is characterized by a dysregulated immune response in which neutrophils play a critical role. Calprotectin reflects neutrophil activation and is involved in the self-amplifying thrombo-inflammatory storm in severe COVID-19. We aimed to evaluate the role of calprotectin in early prediction of severity in COVID-19 patients.\n\nThis was a multicenter prospective observational study enrolling consecutive adult COVID-19 patients. On arrival to emergency department, blood samples were collected for laboratory tests, including serum calprotectin. The primary outcome was severe respiratory failure requiring invasive mechanical ventilation and the secondary outcome was need for Intensive Care Unit (ICU) admission.\n\nStudy population included 395 patients, 57 (14.4%) required invasive mechanical ventilation and 100 (25.3%) were admitted to ICU. Median serum calprotectin levels were significantly higher in intubated (3.73 mg/L vs. 2.63 mg/L; p < 0.001) and ICU patients (3.48 mg/L vs. 2.60 mg/L; p = 0.001). Calprotectin showed a significant accuracy to predict the need for invasive mechanical ventilation (ROC AUC 0.723) and ICU admission (ROC AUC 0.650). In multivariate analysis, serum calprotectin was an independent predictor of invasive mechanical ventilation (OR 1.161) and ICU admission (OR 1.068).\n\nSerum calprotectin can be used as an early predictor of severity in COVID-19 patients.", "doi": "10.1007/s00011-021-01516-4", "pmid": "34718856", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00011-021-01516-4"}], "notes": [], "created": "2021-11-01T19:54:06.861Z", "modified": "2021-11-01T19:54:21.246Z"}, {"entity": "publication", "iuid": "df253a1d3287495c9060e507e78366d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/df253a1d3287495c9060e507e78366d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/df253a1d3287495c9060e507e78366d9"}}, "title": "The mediational role of trust in the healthcare system in the association between generalized trust and willingness to get COVID-19 vaccination in Iran.", "authors": [{"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Yahaghai", "given": "Rafat", "initials": "R"}, {"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-10-29", "journal": {"title": "Hum Vaccin Immunother", "issn": "2164-554X", "pages": "1-8", "issn-l": null}, "abstract": "For some individuals, there appears to be some level of unwillingness in getting a COVID-19 vaccine which may be due to trust issues. The present study used a mediation model to investigate how trust is associated with an individual's willingness to get COVID-19 vaccination among Iranians. A total of 10,843 Iranian adults were recruited in Qazvin province using a multistage stratified cluster sampling method. The survey was completed between February 19 and April 9, 2021. The findings showed that generalized trust was positively associated with trust in the healthcare system, trust in the healthcare system was positively associated with willingness to get COVID-19 vaccination, and generalized trust was positively associated with willingness to get COVID-19 vaccination. Also, trust in the healthcare system mediated the association between generalized trust and willingness to get COVID-19 vaccination. There were some significant demographic differences in COVID-19 vaccination willingness. The findings suggest that generalized trust plays a significant role in directly or indirectly influencing individuals' willingness to get COVID-19 vaccine. Therefore, government bodies and health officials may utilize these findings to appeal in a more transparent and professional manner in encouraging individuals to get a COVID-19 vaccine. However, for those with lower trust levels (in general and in the healthcare system), the focus may be to re-build and/or regain the individuals' trust through carefully planned transparent communication, information dissemination, and ethical education to help increase the uptake of COVID-19 vaccination.", "doi": "10.1080/21645515.2021.1993689", "pmid": "34715009", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:52:03.368Z", "modified": "2021-11-01T19:52:19.468Z"}, {"entity": "publication", "iuid": "629a71d80887407eb7e5a456db40bb93", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/629a71d80887407eb7e5a456db40bb93.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/629a71d80887407eb7e5a456db40bb93"}}, "title": "Patient delay prior to care-seeking in acute myocardial infarction during the outbreak of the coronavirus SARS-CoV2 pandemic.", "authors": [{"family": "Lidin", "given": "Matthias", "initials": "M"}, {"family": "Lyng\u00e5", "given": "Patrik", "initials": "P"}, {"family": "Kinch-Westerdahl", "given": "Annika", "initials": "A"}, {"family": "Nymark", "given": "Carolin", "initials": "C", "orcid": "0000-0003-0891-6358", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26ae7dfc5d824e6ba7fda3c21ac670ef.json"}}], "type": "journal article", "published": "2021-10-29", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "issn-l": null}, "abstract": "To examine patient delay in seeking medical care when afflicted by an acute myocardial infarction during March-June 2020.\n\nThis was a cross-sectional study in a region in Sweden during the first wave of the COVID-19 pandemic examining patients selected from the national registry (SWEDEHEART). Eligible patients were those with acute myocardial infarction, and a total of 602 patients were invited. A self-administered psychometric evaluated questionnaire, 'Patients' appraisal, emotions, and action tendencies preceding care-seeking in acute myocardial infarction' (AMI), was sent to the patients, and questions regarding COVID-19 were added. A total of 326 patients answered the questionnaire. Of these, 19% hesitated to seek medical care because of the pandemic, which was related to a fear that the healthcare services were already overcrowded with patients with COVID-19, followed by a fear of becoming infected with COVID-19 in hospital. Characteristics of this cohort were significantly higher prevalences of women, immigrants, smokers, and patients with type 2 diabetes.\n\nDuring the outbreak and first wave of the COVID-19 pandemic, women and immigrants delayed seeking medical care for AMI because of fears about overcrowded hospitals and about becoming infected themselves. Therefore, during the COVID-19 pandemic, it is especially important to convey information about how and when to seek medical care. A collaboration involving the healthcare professionals, patient organizations, and the media would be desirable.", "doi": "10.1093/eurjcn/zvab087", "pmid": "34718511", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6414289"}], "notes": [], "created": "2021-11-01T19:53:39.156Z", "modified": "2021-11-01T19:53:39.196Z"}, {"entity": "publication", "iuid": "f7807f3a744240b5aa8bc1c5aad426d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7807f3a744240b5aa8bc1c5aad426d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7807f3a744240b5aa8bc1c5aad426d4"}}, "title": "Effect of Resilience on Health-Related Quality of Life during the COVID-19 Pandemic: A Cross-Sectional Study.", "authors": [{"family": "Aldhahi", "given": "Monira I", "initials": "MI", "orcid": "0000-0002-5255-4860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a3b7b4eb7d6440da62df1e4d091329b.json"}}, {"family": "Akil", "given": "Shahnaz", "initials": "S", "orcid": "0000-0002-3256-4543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c031d893b12b4c4ca8cbb330a89384d0.json"}}, {"family": "Zaidi", "given": "Uzma", "initials": "U"}, {"family": "Mortada", "given": "Eman", "initials": "E"}, {"family": "Awad", "given": "Salwa", "initials": "S"}, {"family": "Al Awaji", "given": "Nisreen", "initials": "N", "orcid": "0000-0002-1853-0398", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ea5b5f49bdb409fada8f8aab77ae39b.json"}}], "type": "journal article", "published": "2021-10-29", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "21", "pages": null}, "abstract": "The unprecedented outbreak of coronavirus disease 2019 (COVID-19) has caused a huge global health and economic crisis. The aim of the study was to examine the extent to which the resilience of a person is associated with the quality of life (QoL) of adults amongst Saudi Arabia. A cross-sectional study was conducted among a sample of adults in Saudi Arabia. A total of 385 adults voluntarily participated in and completed the survey. The quality of life was measured using the \"World Health Organization QoL\". The \"Connor-Davidson Resilience Scale\" instrument was also used to assess resilience during the COVID-19 pandemic. Amongst the 385 participants, 179 (46%) showed a good QoL, and 205 (54%) reported a relatively poor QoL. The resilience was found to be significantly associated with QoL. The study further revealed that gender-based differences were dominant in the QoL; the men respondents reported a significantly higher QoL in all the domains in comparison to the women respondents. The gender, income, and psychological health and interaction effect of resilience and age explained 40% of the variance in the total score of QoL. In reference to the predictors of the physical health domain of QoL, resilience, gender, and psychological health were significantly associated with the physical health domain of the QoL (R2 = 0.26, p = 0.001). It was also noted that gender was not associated with the social relationships and environmental domains of QoL (p > 0.05). Findings showed a statistically significant association between the score of QoL and resilience, age, gender, income, and psychological health. These findings highlight the significant contribution of gender-based differences, psychological health, and resilience on the domains of QoL.", "doi": "10.3390/ijerph182111394", "pmid": "34769907", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182111394"}, {"db": "pmc", "key": "PMC8582796"}], "notes": [], "created": "2021-11-26T15:09:47.678Z", "modified": "2022-02-17T12:26:29.079Z"}, {"entity": "publication", "iuid": "6b1c03b1fc744ce7bd7498966d975600", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b1c03b1fc744ce7bd7498966d975600.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b1c03b1fc744ce7bd7498966d975600"}}, "title": "Detection of SARS-CoV-2 by rapid antigen tests on saliva in hospitalized patients with COVID-19.", "authors": [{"family": "De Marinis", "given": "Yang", "initials": "Y", "orcid": "0000-0002-8081-2142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c85c6f6e14a44415a2bea1cfe224e50c.json"}}, {"family": "Pesola", "given": "Anne-Katrine", "initials": "AK"}, {"family": "S\u00f6derlund Strand", "given": "Anna", "initials": "A"}, {"family": "Norman", "given": "Astrid", "initials": "A"}, {"family": "Pernow", "given": "Gustav", "initials": "G"}, {"family": "Ald\u00e9n", "given": "Markus", "initials": "M"}, {"family": "Yang", "given": "Runtao", "initials": "R"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1588-5473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c760e8d21ae441ba236f86e6185d392.json"}}], "type": "journal article", "published": "2021-10-29", "journal": {"title": "Infect Ecol Epidemiol", "issn": "2000-8686", "volume": "11", "issue": "1", "pages": "1993535", "issn-l": "2000-8686"}, "abstract": "The COVID-19 pandemic presents great challenges on transmission prevention, and rapid diagnosis is essential to reduce the disease spread. Various diagnostic methods are available to identify an ongoing infection by nasopharyngeal (NPH) swab sampling. However, the procedure requires handling by health care professionals, and therefore limits the application in household and community settings.\n\nIn this study, we aimed to determine if the detection of SARS-CoV-2 can be performed alternatively on saliva specimens by rapid antigen test.\n\nSaliva and NPH specimens were collected from 44 patients with confirmed COVID-19. To assess the diagnostic accuracy of point-of-care SARS-CoV-2 rapid antigen test on saliva specimens, we compared the performance of four test products.\n\nRT-qPCR was performed and NPH and saliva sampling had similar Ct values, which associated with disease duration. All four antigen tests showed similar trend in detecting SARS-CoV-2 in saliva, but with variation in the ability to detect positive cases. The rapid antigen test with the best performance could detect up to 67% of the positive cases with Ct values lower than 25, and disease duration shorter than 10 days.\n\nOur study therefore supports saliva testing as an alternative diagnostic procedure to NPH testing, and that rapid antigen test on saliva provides a potential complement to PCR test to meet increasing screening demand.", "doi": "10.1080/20008686.2021.1993535", "pmid": "34745449", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "1993535"}, {"db": "pmc", "key": "PMC8567870"}], "notes": [], "created": "2021-11-10T11:40:29.186Z", "modified": "2021-11-26T15:35:05.776Z"}, {"entity": "publication", "iuid": "62ff8b720a574f95a3e5c8707da35fd6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/62ff8b720a574f95a3e5c8707da35fd6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/62ff8b720a574f95a3e5c8707da35fd6"}}, "title": "The Barriers, Challenges, and Strategies of COVID-19 (SARS-CoV-2) Vaccine Acceptance: A Concurrent Mixed-Method Study in Tehran City, Iran.", "authors": [{"family": "Khankeh", "given": "Hamid Reza", "initials": "HR"}, {"family": "Farrokhi", "given": "Mehrdad", "initials": "M"}, {"family": "Khanjani", "given": "Mohammad Saeed", "initials": "MS"}, {"family": "Momtaz", "given": "Yadollah Abolfathi", "initials": "YA", "orcid": "0000-0003-1939-1470", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d0e1d04e09d74c19b349fac72d8e6cd7.json"}}, {"family": "Forouzan", "given": "Ameneh Setareh", "initials": "AS", "orcid": "0000-0001-9668-1389", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80e56b61b3a0447ebd9865c0f1a734a7.json"}}, {"family": "Norouzi", "given": "Mehdi", "initials": "M"}, {"family": "Ahmadi", "given": "Shokoufeh", "initials": "S"}, {"family": "Harouni", "given": "Gholamreza Ghaedamini", "initials": "GG", "orcid": "0000-0003-1197-5068", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09e64a733cff438ea73ced998027307d.json"}}, {"family": "Roudini", "given": "Juliet", "initials": "J"}, {"family": "Ghanaatpisheh", "given": "Elham", "initials": "E"}, {"family": "Hamedanchi", "given": "Arya", "initials": "A", "orcid": "0000-0001-5879-5561", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69adb9f4402744879df4d532e6d609a8.json"}}, {"family": "Pourebrahimi", "given": "Mohammad", "initials": "M"}, {"family": "Alipour", "given": "Fardin", "initials": "F"}, {"family": "Ranjbar", "given": "Maryam", "initials": "M"}, {"family": "Naghikhani", "given": "Mehrdad", "initials": "M"}, {"family": "Saatchi", "given": "Mohammad", "initials": "M"}], "type": "journal article", "published": "2021-10-28", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "9", "issue": "11", "issn-l": null}, "abstract": "Acceptance and willingness to receive the vaccine are among the main factors in the success or failure of a health system in implementing the vaccination program. The present study was conducted in Tehran, the political and economic capital of Iran, to determine the acceptance of the COVID-19 vaccine and identify its associated factors, and explain the most important barriers and acceptance strategies for vaccination. This research was a concurrent quantitative and qualitative mixed-method study. In the quantitative part, 1200 individuals aged more than 18 years were selected from the households in 22 districts of Tehran City, with a multistage stratified cluster sampling method. Two questionnaires were used to evaluate the acceptance of the COVID-19 vaccine and vaccine acceptance determinants. The qualitative content analysis method addressed the influencing factors, as well as challenges and strategies related to the acceptance of the COVID-19 vaccine in four groups of Tehran inhabitants: the elderly, people with underlying diseases, healthcare workers, and the general population. The related data were simultaneously collected by applying in-depth semi-structural interviews and a data analysis process. Furthermore, we used the Graneheim and Lundman method for data analysis. We analyzed the data of 1200 people with a mean (SD) age of 46.4 (11.1) years, and approximately 58% of them were men. The vaccine acceptance was 83.6% (95% CI: 81.3-85.9). Among those who welcomed vaccination, 58% preferred the imported vaccines, 25% the Iranian ones, and 17% both. There was a significant association between the variables of age (adjusted odds ratio [AOR] = 1.72, 95% CI: 1.01-2.93), being single (AOR = 0.54, 95% CI: 0.41-0.91), moderate pharmacotherapy adherence (AOR = 0.58, 95% CI: 0.4-0.85), and the willingness to receive COVID-19 vaccine. Qualitative study after interviewing 45 people from four study groups showed an insufficient social trust in healthcare system officials, pharmaceutical and vaccine production companies; distrust in the effectiveness of the vaccines, concerns about the vaccine adverse effects, being tracked by microchips after vaccination, traditional anti-vaccination movements, the feeling the inessentiality of vaccination, and uncertainty about the fair distribution of the vaccine. These concerns were the main challenges addressed by the study groups. A good proportion of Tehran residents reported their willingness to receive the COVID-19 vaccine. Additionally, they expressed their critical concerns, such as insufficient trust in the healthcare system, vaccine safeties, and adverse effects that were the significant barriers to vaccine acceptance. It seems that conflicts raised by the shortage of vaccines and their import due to the sanctions have led to intense desire and demand in the general population, and especially the elderly, for vaccination. Besides, vaccination phobia in some individuals requires further investigations.", "doi": "10.3390/vaccines9111248", "pmid": "34835179", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "vaccines9111248"}, {"db": "pmc", "key": "PMC8620861"}], "notes": [], "created": "2021-12-18T18:14:17.824Z", "modified": "2021-12-18T18:14:30.396Z"}, {"entity": "publication", "iuid": "16b970005ba045cfb91c5d275a6062f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16b970005ba045cfb91c5d275a6062f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16b970005ba045cfb91c5d275a6062f1"}}, "title": "Rapid inactivation of SARS-CoV-2 with LED irradiation of visible spectrum wavelengths.", "authors": [{"family": "De Santis", "given": "Riccardo", "initials": "R"}, {"family": "Luca", "given": "Vincenzo", "initials": "V"}, {"family": "N\u00e4slund", "given": "Jonas", "initials": "J"}, {"family": "Ehmann", "given": "Rosina K", "initials": "RK"}, {"family": "De Angelis", "given": "Marta", "initials": "M"}, {"family": "Lundmark", "given": "Eva", "initials": "E"}, {"family": "Nencioni", "given": "Lucia", "initials": "L"}, {"family": "Faggioni", "given": "Giovanni", "initials": "G"}, {"family": "Fillo", "given": "Silvia", "initials": "S"}, {"family": "Amatore", "given": "Donatella", "initials": "D"}, {"family": "Regalbuto", "given": "Elisa", "initials": "E"}, {"family": "Molinari", "given": "Filippo", "initials": "F"}, {"family": "Petralito", "given": "Giancarlo", "initials": "G"}, {"family": "W\u00f6lfel", "given": "Roman", "initials": "R"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Rezza", "given": "Gianni", "initials": "G"}, {"family": "Palamara", "given": "Anna Teresa", "initials": "AT"}, {"family": "Antwerpen", "given": "Markus", "initials": "M"}, {"family": "Forsman", "given": "Mats", "initials": "M"}, {"family": "Lista", "given": "Florigio", "initials": "F"}], "type": "journal article", "published": "2021-10-28", "journal": {"title": "J Photochem Photobiol", "issn": "2666-4690", "pages": "100082", "issn-l": null}, "abstract": "Difficulty in controlling SARS-CoV-2 transmission made the ability to inactivate viruses in aerosols and fomites to be an important and attractive risk reduction measure. Evidence that light frequencies have the ability to inhibit microorganisms has already been reported by many studies which, however, focused on ultraviolet (UV) wavelengths, which are known to induce potential injury in humans. In the present study, the effect on suspensions of SARS-CoV-2 of a Light Emitting Diode (LED) device capable of radiating frequencies in the non-hazardous visible light spectrum (VIS) was investigated. In order to evaluate the efficiency of viral inactivation, plaque assay and western blot of viral proteins were performed. The observed results showed a significant reduction in infectious particles that had been exposed to the LED irradiation of visible light. Furthermore, the analysis of the intracellular expression of viral proteins confirmed the inactivating effect of this irradiation technology. This in vitro study revealed for the first time the inactivation of SAR-CoV-2 through LED irradiation with multiple wavelengths of the visible spectrum. However additional and more in-depth studies can aim to demonstrate the data obtained during these experiments in different matrices, in mutable environmental conditions and on other respiratory viruses such as the influenza virus, the type of LED technology can decisively contribute on reducing virus transmission through the continuous sanitation of common environments without risks for humans and animals.", "doi": "10.1016/j.jpap.2021.100082", "pmid": "34729540", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2666-4690(21)00067-1"}, {"db": "pmc", "key": "PMC8552801"}], "notes": [], "created": "2021-11-08T09:06:28.550Z", "modified": "2021-11-08T09:06:28.588Z"}, {"entity": "publication", "iuid": "66a83c2299dc46f2b4ae52efcb0ca12a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66a83c2299dc46f2b4ae52efcb0ca12a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66a83c2299dc46f2b4ae52efcb0ca12a"}}, "title": "Health, Lifestyle, and Psycho-Social Determinants of Poor Sleep Quality During the Early Phase of the COVID-19 Pandemic: A Focus on UK Older Adults Deemed Clinically Extremely Vulnerable.", "authors": [{"family": "Udeh-Momoh", "given": "Chinedu T", "initials": "CT"}, {"family": "Watermeyer", "given": "Tamlyn", "initials": "T"}, {"family": "Sindi", "given": "Shireen", "initials": "S"}, {"family": "Giannakopoulou", "given": "Parthenia", "initials": "P"}, {"family": "Robb", "given": "Catherine E", "initials": "CE"}, {"family": "Ahmadi-Abhari", "given": "Sara", "initials": "S"}, {"family": "Zheng", "given": "Bang", "initials": "B"}, {"family": "Waheed", "given": "Amina", "initials": "A"}, {"family": "McKeand", "given": "James", "initials": "J"}, {"family": "Salman", "given": "David", "initials": "D"}, {"family": "Beaney", "given": "Thomas", "initials": "T"}, {"family": "de Jager Loots", "given": "Celeste A", "initials": "CA"}, {"family": "Price", "given": "Geraint", "initials": "G"}, {"family": "Atchison", "given": "Christina", "initials": "C"}, {"family": "Car", "given": "Josip", "initials": "J"}, {"family": "Majeed", "given": "Azeem", "initials": "A"}, {"family": "McGregor", "given": "Alison H", "initials": "AH"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Ward", "given": "Helen", "initials": "H"}, {"family": "Middleton", "given": "Lefkos T", "initials": "LT"}], "type": "journal article", "published": "2021-10-28", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "753964", "issn-l": "2296-2565"}, "abstract": "Background: Several studies have assessed the impact of COVID-19-related lockdowns on sleep quality across global populations. However, no study to date has specifically assessed at-risk populations, particularly those at highest risk of complications from coronavirus infection deemed \"clinically-extremely-vulnerable-(COVID-19CEV)\" (as defined by Public Health England). Methods: In this cross-sectional study, we surveyed 5,558 adults aged \u226550 years (of whom 523 met criteria for COVID-19CEV) during the first pandemic wave that resulted in a nationwide-lockdown (April-June 2020) with assessments of sleep quality (an adapted sleep scale that captured multiple sleep indices before and during the lockdown), health/medical, lifestyle, psychosocial and socio-demographic factors. We examined associations between these variables and sleep quality; and explored interactions of COVID-19CEV status with significant predictors of poor sleep, to identify potential moderating factors. Results: Thirty-seven percent of participants reported poor sleep quality which was associated with younger age, female sex and multimorbidity. Significant associations with poor sleep included health/medical factors: COVID-19CEV status, higher BMI, arthritis, pulmonary disease, and mental health disorders; and the following lifestyle and psychosocial factors: living alone, higher alcohol consumption, an unhealthy diet and higher depressive and anxiety symptoms. Moderators of the negative relationship between COVID-19CEV status and good sleep quality were marital status, loneliness, anxiety and diet. Within this subgroup, less anxious and less lonely males, as well as females with healthier diets, reported better sleep. Conclusions: Sleep quality in older adults was compromised during the sudden unprecedented nation-wide lockdown due to distinct modifiable factors. An important contribution of our study is the assessment of a \"clinically-extremely-vulnerable\" population and the sex differences identified within this group. Male and female older adults deemed COVID-19CEV may benefit from targeted mental health and dietary interventions, respectively. This work extends the available evidence on the notable impact of lack of social interactions during the COVID-19 pandemic on sleep, and provides recommendations toward areas for future work, including research into vulnerability factors impacting sleep disruption and COVID-19-related complications. Study results may inform tailored interventions targeted at modifiable risk factors to promote optimal sleep; additionally, providing empirical data to support health policy development in this area.", "doi": "10.3389/fpubh.2021.753964", "pmid": "34869170", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8637825"}], "notes": [], "created": "2021-12-12T07:09:20.670Z", "modified": "2021-12-12T07:09:20.684Z"}, {"entity": "publication", "iuid": "3217be6cf6ad4eaeaffbf01370c6b69d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3217be6cf6ad4eaeaffbf01370c6b69d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3217be6cf6ad4eaeaffbf01370c6b69d"}}, "title": "Comparative safety of mRNA COVID-19 vaccines to influenza vaccines: A pharmacovigilance analysis using WHO international database.", "authors": [{"family": "Kim", "given": "Min Seo", "initials": "MS", "orcid": "0000-0003-2115-7835", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3078a38bd45044b3ac5b32d0eb09fbda.json"}}, {"family": "Jung", "given": "Se Yong", "initials": "SY", "orcid": "0000-0003-1337-563X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e77bcc25ff234e30b8b5b67aab7dc06f.json"}}, {"family": "Ahn", "given": "Jong Gyun", "initials": "JG"}, {"family": "Park", "given": "Se Jin", "initials": "SJ"}, {"family": "Shoenfeld", "given": "Yehuda", "initials": "Y"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Tizaoui", "given": "Kalthoum", "initials": "K", "orcid": "0000-0001-8524-6058", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/acc834b554f14509911d1a594332a808.json"}}, {"family": "Hong", "given": "Sung Hwi", "initials": "SH"}, {"family": "Jacob", "given": "Louis", "initials": "L", "orcid": "0000-0003-1071-1239", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f59bc7c0941a462aa7426d8e2a995b30.json"}}, {"family": "Salem", "given": "Joe-Elie", "initials": "JE"}, {"family": "Yon", "given": "Dong Keon", "initials": "DK", "orcid": "0000-0003-1628-9948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/747eb5856d2e444fbc1e5aaef8d3aa40.json"}}, {"family": "Lee", "given": "Seung Won", "initials": "SW", "orcid": "0000-0001-5632-5208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b38b67e00dbf4d80a72a30152b99c0a3.json"}}, {"family": "Ogino", "given": "Shuji", "initials": "S", "orcid": "0000-0002-3909-2323", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/310326a713e7419ba514ded7472e97b6.json"}}, {"family": "Kim", "given": "Hanna", "initials": "H"}, {"family": "Kim", "given": "Jerome H", "initials": "JH"}, {"family": "Excler", "given": "Jean-Louis", "initials": "JL"}, {"family": "Marks", "given": "Florian", "initials": "F"}, {"family": "Clemens", "given": "John D", "initials": "JD"}, {"family": "Eisenhut", "given": "Michael", "initials": "M"}, {"family": "Barnett", "given": "Yvonne", "initials": "Y"}, {"family": "Butler", "given": "Laurie", "initials": "L"}, {"family": "Ilie", "given": "Cristian Petre", "initials": "CP"}, {"family": "Shin", "given": "Eui-Cheol", "initials": "EC", "orcid": "0000-0002-6308-9503", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbc368fed9a340a1adcd420100422844.json"}}, {"family": "Il Shin", "given": "Jae", "initials": "J", "orcid": "0000-0003-2326-1820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ca450cb43e3478d81ba93be745f0ea0.json"}}, {"family": "Smith", "given": "Lee", "initials": "L"}], "type": "journal article", "published": "2021-10-28", "journal": {"title": "J Med Virol", "issn": "1096-9071", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Two messenger RNA (mRNA) vaccines developed by Pfizer-BioNTech and Moderna are being rolled out. Despite the high volume of emerging evidence regarding adverse events (AEs) associated with the COVID-19 mRNA vaccines, previous studies have thus far been largely based on the comparison between vaccinated and unvaccinated control, possibly highlighting the AE risks with COVID-19 mRNA vaccination. Comparing the safety profile of mRNA vaccinated individuals with otherwise vaccinated individuals would enable a more relevant assessment for the safety of mRNA vaccination. We designed a comparative safety study between 18 755 and 27 895 individuals who reported to VigiBase for adverse events following immunization (AEFI) with mRNA COVID-19 and influenza vaccines, respectively, from January 1, 2020, to January 17, 2021. We employed disproportionality analysis to rapidly detect relevant safety signals and compared comparative risks of a diverse span of AEFIs for the vaccines. The safety profile of novel mRNA vaccines was divergent from that of influenza vaccines. The overall pattern suggested that systematic reactions like chill, myalgia, fatigue were more noticeable with the mRNA COVID-19 vaccine, while injection site reactogenicity events were more prevalent with the influenza vaccine. Compared to the influenza vaccine, mRNA COVID-19 vaccines demonstrated a significantly higher risk for a few manageable cardiovascular complications, such as hypertensive crisis (adjusted reporting odds ratio [ROR], 12.72; 95% confidence interval [CI], 2.47-65.54), and supraventricular tachycardia (adjusted ROR, 7.94; 95% CI, 2.62-24.00), but lower risk of neurological complications such as syncope, neuralgia, loss of consciousness, Guillain-Barre syndrome, gait disturbance, visual impairment, and dyskinesia. This study has not identified significant safety concerns regarding mRNA vaccination in real-world settings. The overall safety profile patterned a lower risk of serious AEFI following mRNA vaccines compared to influenza vaccines.", "doi": "10.1002/jmv.27424", "pmid": "34709664", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:48:34.182Z", "modified": "2021-11-29T06:07:21.030Z"}, {"entity": "publication", "iuid": "9ca3a6ec6e8b40ed879bd7983425ed90", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ca3a6ec6e8b40ed879bd7983425ed90.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ca3a6ec6e8b40ed879bd7983425ed90"}}, "title": "Comments on the Discussion Forum: Oromucosal immunomodulation as clinical spectrum mitigating factor in SARS-CoV-2 infection.", "authors": [{"family": "Smith", "given": "Michael L", "initials": "ML", "orcid": "0000-0003-4103-8614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4c9b76424464a188d2880c45a0f4303.json"}}, {"family": "Sharma", "given": "Sujata", "initials": "S"}, {"family": "Singh", "given": "Tej P", "initials": "TP"}], "type": "journal article", "published": "2021-10-28", "journal": {"title": "Scand J Immunol", "issn": "1365-3083", "pages": "e13111", "issn-l": null}, "abstract": "We read the excellent presentation by Rodriguez-Argente and coauthors and wish to add some thoughts to the discussion1 . The lactoperoxidase (LPO) system is actually the first line of mammalian, immunological defense against airborne bacterial and viral infections, including influenza and the respiratory syncytial virus (RSV)2,3 . This is not well known and some textbooks of immunology don't even mention this system.", "doi": "10.1111/sji.13111", "pmid": "34709678", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:49:35.555Z", "modified": "2021-11-01T19:49:35.593Z"}, {"entity": "publication", "iuid": "392bb2b4eb104c54bcf476998fd646df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/392bb2b4eb104c54bcf476998fd646df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/392bb2b4eb104c54bcf476998fd646df"}}, "title": "COVID-19 in lung transplant recipients: an overview of the Swedish national experience.", "authors": [{"family": "Magnusson", "given": "Jesper M", "initials": "JM"}, {"family": "Larsson", "given": "Hillevi", "initials": "H"}, {"family": "Alsaleh", "given": "Ahmed", "initials": "A"}, {"family": "Ekelund", "given": "Jan", "initials": "J"}, {"family": "Karason", "given": "Kristjan", "initials": "K"}, {"family": "Schult", "given": "Andreas", "initials": "A"}, {"family": "Friman", "given": "Vanda", "initials": "V"}, {"family": "Felldin", "given": "Marie", "initials": "M"}, {"family": "S\u00f8fteland", "given": "John Mackay", "initials": "JM"}, {"family": "Dellgren", "given": "G\u00f6ran", "initials": "G"}, {"family": "Oltean", "given": "Mihai", "initials": "M"}], "type": "journal article", "published": "2021-10-28", "journal": {"title": "Transpl Int", "issn": "1432-2277", "issn-l": null}, "abstract": "Although it is known that solid organ transplant recipients fare worse after COVID-19 infection, data on the impact of COVID-19 on clinical outcomes and allograft function in lung transplant (LTx) recipients are limited and based mainly on reports with short follow-up.\n\nIn this nationwide study, all LTx recipients with COVID-19 diagnosed from February 1st, 2020 to April 30th, 2021, were included. The patients were followed until August 1st 2021, or death. We analysed demographics, clinical features, therapeutic management, and outcomes, including lung function.\n\nForty-seven patients were identified: median age was 59 (10-78) years, 53.1% were male, and median follow-up was 194 (23-509) days. COVID-19 was asymptomatic or mild at presentation in 48.9%. Nine patients (19.1%) were vaccinated pre-COVID infection. Two patients (4.3%) died within 28 days of testing positive, and the overall survival rate was 85.1%. The patients with asymptomatic or mild symptoms had a higher median % expected forced expiratory volume during the first second than the patients with worse symptoms (p=0.004).\n\nLTx recipients develop the entire spectrum of COVID-19, and in addition to previously acknowledged risk factors, lower pre-COVID lung function was associated with more severe disease presentation.", "doi": "10.1111/tri.14148", "pmid": "34709680", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:50:31.415Z", "modified": "2021-11-01T19:50:31.428Z"}, {"entity": "publication", "iuid": "00b63ab548dd4754b5f8e8d7edad2fdd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/00b63ab548dd4754b5f8e8d7edad2fdd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/00b63ab548dd4754b5f8e8d7edad2fdd"}}, "title": "COVID-19 Vaccinations: Summary Guidance for Cancer Patients in 28 Languages: Breaking Barriers to Cancer Patient Information.", "authors": [{"family": "Davide", "given": "Mauri", "initials": "M"}, {"family": "Kamposioras", "given": "Konstantinos", "initials": "K"}, {"family": "Lampriani", "given": "Tsali", "initials": "T"}, {"family": "Mario", "given": "Dambrosio", "initials": "D"}, {"family": "Berardino", "given": "De Bari", "initials": "B"}, {"family": "Nadia", "given": "Hindi", "initials": "H"}, {"family": "Carl", "given": "Salembier", "initials": "S"}, {"family": "Joanna", "given": "Nixon", "initials": "N"}, {"family": "Dimitrios", "given": "Tzachanis", "initials": "T"}, {"family": "Flippo", "given": "Alongi", "initials": "A"}, {"family": "Hassan", "given": "Hameed", "initials": "H"}, {"family": "Antonios", "given": "Valachis", "initials": "V"}, {"family": "Konstantinos", "given": "Papadimitriou", "initials": "P"}, {"family": "Stefanie", "given": "Corradini", "initials": "C"}, {"family": "Lazar", "given": "Popovic", "initials": "P"}, {"family": "Jindrich", "given": "Kopecky", "initials": "K"}, {"family": "Andres", "given": "Rodriguez", "initials": "R"}, {"family": "Katarina", "given": "Antunac", "initials": "A"}, {"family": "Junlin", "given": "Yi", "initials": "Y"}, {"family": "Lovey", "given": "Jozsef", "initials": "J"}, {"family": "Primoz", "given": "Strojan", "initials": "S"}, {"family": "Haytham", "given": "Saraireh", "initials": "S"}, {"family": "Ranveig", "given": "R\u00f8tterud", "initials": "R"}, {"family": "Marzanna", "given": "Chojnacka", "initials": "C"}, {"family": "Olalla", "given": "Santa Cruz", "initials": "SC"}, {"family": "Natalia", "given": "Chilingirova", "initials": "C"}, {"family": "Ramon A", "given": "De Mello", "initials": "M"}, {"family": "Giovanna", "given": "Araujo Amaral", "initials": "AA"}, {"family": "Farsid", "given": "Arbabi", "initials": "A"}, {"family": "Radu", "given": "Vidra", "initials": "V"}, {"family": "Erjeta", "given": "Rapushi", "initials": "R"}, {"family": "D", "given": "Takeuchi", "initials": "T"}, {"family": "Chirstos", "given": "Christopoulos", "initials": "C"}, {"family": "Irina", "given": "Ivanova", "initials": "I"}, {"family": "Igor", "given": "Djan", "initials": "D"}, {"family": "Branka", "given": "Petricevic", "initials": "P"}, {"family": "Francesco", "given": "Cellini", "initials": "C"}, {"family": "Iglika", "given": "Mihaylova", "initials": "M"}, {"family": "Natalija", "given": "Dedic Plavetic", "initials": "DP"}, {"family": "Cvetka", "given": "Gra\u0161i\u010d Kuhar", "initials": "GK"}, {"family": "Elena", "given": "Takeuchi", "initials": "T"}, {"family": "Pantelis", "given": "Kountourakis", "initials": "K"}, {"family": "Panagiotis", "given": "Ntellas", "initials": "N"}, {"family": "Ioanna", "given": "Gazouli", "initials": "G"}, {"family": "Stefania", "given": "Gkoura", "initials": "G"}, {"family": "Salih", "given": "Yuce", "initials": "Y"}, {"family": "Er", "given": "\u00d6zlem", "initials": "\u00d6"}, {"family": "Yasmina", "given": "Chait", "initials": "C"}, {"family": "Kumaran", "given": "Gireesh", "initials": "G"}, {"family": "Orges", "given": "Spahiu", "initials": "S"}, {"family": "Aasim", "given": "Yusuf", "initials": "Y"}, {"family": "Gono", "given": "Paulina", "initials": "P"}, {"family": "Apostolidis", "given": "Kathi", "initials": "K"}, {"family": "Tolia", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-10-28", "journal": {"title": "Rev Recent Clin Trials", "issn": "1876-1038", "issn-l": null}, "abstract": "Covid-19 vaccination has started in the majority of the countries at the global level. Cancer patients are at high risk for infection, serious illness, and death from COVID-19 and need vaccination guidance and support. Guidance availability in the English language only is a major limit for recommendations' delivery and their application in the world's population and generates information inequalities across the different populations.\n\nMost of the available COVID-19 vaccination guidance for cancer patients was screened and scrutinized by the European Cancer Patients Coalition (ECPC) and an international oncology panel of 52 physicians from 33 countries.\n\nA summary guidance was developed and provided in 28 languages in order to reach more than 70 percent of the global population.\n\nLanguage barrier and e-guidance availability in the native language are the most important barriers when communicating with patients. E-guidance availability in various native languages should be considered a major priority by international medical and health organizations that are communicating with patients at the global level.<\/P>.", "doi": "10.2174/1574887116666211028145848", "pmid": "34967300", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "RRCT-EPUB-118603"}], "notes": [], "created": "2022-01-04T14:59:21.002Z", "modified": "2022-01-04T14:59:31.343Z"}, {"entity": "publication", "iuid": "7d83002c4ecd4eef919999fe1fdaca8a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d83002c4ecd4eef919999fe1fdaca8a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d83002c4ecd4eef919999fe1fdaca8a"}}, "title": "The impact of the COVID-19 pandemic on autoimmune diagnostics in Europe: A lesson to be learned.", "authors": [{"family": "Nagy", "given": "Eszter", "initials": "E"}, {"family": "Infantino", "given": "Maria", "initials": "M"}, {"family": "Bizzaro", "given": "Nicola", "initials": "N"}, {"family": "Andreeva", "given": "Hristina", "initials": "H"}, {"family": "Bontkes", "given": "Hetty J", "initials": "HJ"}, {"family": "Bossuyt", "given": "Xavier", "initials": "X"}, {"family": "Fabien", "given": "Nicole", "initials": "N"}, {"family": "Fischer", "given": "Katarzyna", "initials": "K"}, {"family": "Heijnen", "given": "Ingmar A F M", "initials": "IAFM"}, {"family": "Herold", "given": "Manfred", "initials": "M"}, {"family": "Kozmar", "given": "Ana", "initials": "A"}, {"family": "Kuhi", "given": "Liisa", "initials": "L"}, {"family": "L\u00f3pez-Hoyos", "given": "Marcos", "initials": "M"}, {"family": "Pullerits", "given": "Rille", "initials": "R"}, {"family": "Sousa", "given": "Maria Jos\u00e9 Rego", "initials": "MJR"}, {"family": "Tsirogianni", "given": "Alexandra", "initials": "A"}, {"family": "Damoiseaux", "given": "Jan", "initials": "J"}, {"family": "European Autoimmunity Standardisation Initiative", "given": "", "initials": ""}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "Autoimmun Rev", "issn": "1873-0183", "pages": "102985", "issn-l": null}, "abstract": "The first wave of COVID-19 pandemic has disrupted almost all areas of the health care services to some extent throughout the world. Although the negative impact of COVID-19 on patients with autoimmune diseases has also been recognized, available data in this regard are limited. In the current study of the European Autoimmunity Standardisation Initiative (EASI) we aimed to provide reliable data on the extent of the impact of COVID-19 pandemic on test requests for different autoantibodies in European countries.\n\nData on test numbers and on the number of positive results were collected in 97 clinical laboratories from 15 European countries on a monthly basis for the year before (2019) and the year during (2020) the COVID-19 pandemic.\n\nA reduction in the number of autoantibody tests was observed in all European countries in the year 2020 compared to 2019. The reduction affected all autoantibody tests with an overall decrease of 13%, ranging from 1.4% (Switzerland) to 25.5% (Greece). In all countries, the decrease was most pronounced during the first wave of the pandemic (March-May 2020) with an overall decrease in those three months of 45.2%. The most affected autoantibodies were those commonly requested by general practitioners (anti-tTG IgA (-71%), RF IgM (-66%) and ACPA (-61%)). In the second wave of the pandemic (October-December 2020) the decrease was less pronounced (6.8%). With respect to the rate of positive results, subtle differences were observed for distinct autoantibodies during the pandemic, but the total rate of positive results was similar in both years.\n\nOur study demonstrated a strong decrease in autoantibody requests during the first wave of the COVID-19 pandemic in 15 European countries. The second wave was characterized by a less pronounced impact, with some participating countries hardly affected, while some other countries experienced a second decline. The decrease was clearly associated with the level of lock-down and with the required adjustments in the health care systems in different countries, supporting the importance of an effective strategy for the coordination of autoimmune testing in challenging situations as the COVID-19 pandemic.", "doi": "10.1016/j.autrev.2021.102985", "pmid": "34718167", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1568-9972(21)00265-2"}], "notes": [], "created": "2021-11-01T19:53:22.570Z", "modified": "2021-11-01T19:53:22.584Z"}, {"entity": "publication", "iuid": "9f874862068d4cd791f845d47d2425ce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f874862068d4cd791f845d47d2425ce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f874862068d4cd791f845d47d2425ce"}}, "title": "The COVID-19 pandemic and ANCA-associated vasculitis - reports from the EUVAS meeting and EUVAS education forum.", "authors": [{"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Geetha", "given": "Duvuru", "initials": "D"}, {"family": "Smith", "given": "Rona M", "initials": "RM"}, {"family": "Egan", "given": "Allyson C", "initials": "AC"}, {"family": "Bajema", "given": "Ingeborg M", "initials": "IM"}, {"family": "Sch\u00f6nermarck", "given": "Ulf", "initials": "U"}, {"family": "Mahr", "given": "Alfred", "initials": "A"}, {"family": "Anders", "given": "Hans-Joachim", "initials": "HJ"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Cid", "given": "Maria C", "initials": "MC"}, {"family": "Jayne", "given": "David R W", "initials": "DRW"}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "Autoimmun Rev", "issn": "1873-0183", "pages": "102986", "issn-l": null}, "abstract": "The Coronavirus Disease 2019 (COVID-19) pandemic influenced the management of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. A paucity of data exists on outcome of patients with vasculitis following COVID-19, but mortality is higher than in the general population and comparable to patients undergoing haemodialysis or kidney transplant recipients (reported mortality rates of 20-25%). Delays in diagnosis have been reported, which are associated with sequelae such as dialysis-dependency. Management of ANCA-associated vasculitis has not changed with the aim to suppress disease activity and reduce burden of disease. The use of rituximab, an important and widely used agent, is associated with a more severe hospital course of COVID-19 and absence of antibodies following severe acute respiratory syndrome (SARS)-CoV-2 infections, which prone patients to re-infection. Reports on vaccine antibody response are scarce at the moment, but preliminary findings point towards an impaired immune response, especially when patients receive rituximab as part of their treatment. Seropositivity was reported in less than 20% of patients when rituximab was administered within the prior six months, and the antibody response correlated with CD19+ B-cell repopulation. A delay in maintenance doses, if disease activity allows, has been suggested using a CD19+ B-cell guided strategy. Other immunosuppressive measures, which are used in ANCA-associated vasculitis, also impair humoral and cellular vaccine responses. Regular measurements of vaccine response or a healthcare-policy time-based strategy are indicated to provide additional doses (\"booster\") of COVID-19 vaccines. This review summarizes a recent educational forum and a recent virtual meeting of the European Vasculitis Society (EUVAS) focusing on COVID-19.", "doi": "10.1016/j.autrev.2021.102986", "pmid": "34718165", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1568-9972(21)00266-4"}], "notes": [], "created": "2021-11-01T19:53:00.767Z", "modified": "2021-11-01T19:53:00.781Z"}, {"entity": "publication", "iuid": "56a3ee64de654942a1344e5dd2026dd1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56a3ee64de654942a1344e5dd2026dd1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56a3ee64de654942a1344e5dd2026dd1"}}, "title": "Susceptibility of Dog, Hamster, and Mouse Cells to the Replication-Competent Adenovirus 11p E1/E3 Green Fluorescence Protein Vector Has Implications for the Selection of Animal Vaccine Models.", "authors": [{"family": "Gokumakulapalle", "given": "Madhuri", "initials": "M"}, {"family": "Wang", "given": "Li", "initials": "L"}, {"family": "Mei", "given": "Ya-Fang", "initials": "YF"}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "Front Microbiol", "issn": "1664-302X", "volume": "12", "pages": "698999", "issn-l": null}, "abstract": "Human adenovirus (Ad)-vectored vaccines require viruses that can internalize into host cells and express the vaccine antigen. Evaluation of the expressed antigen in animal cells is a critical step in preclinical trials of viral vaccines. Due to the species specificity of Ads, it is difficult to find a suitable animal model. Thus, in this study, we compared the efficacy of Ad 11 prototype (Ad11p)-mediated green fluorescence protein (GFP) expression in cell lines of dog (MDCK), hamster (CHO), and mouse (McCoy and C127). Although these cell lines did not express the known primary cellular receptors for Ad11p virus infection (i.e., CD46), Ad11pE1GFP could infect and express GFP with various efficacies. For instance, it manifested relatively higher GFP expression in MDCK than in CHO, McCoy, and C127. However, infection leading to efficient viral release was not observed in any of the studied cell lines. The apparent differences were attributed to particularities of mouse and hamster cell lines, which might have led to the repression of viral DNA synthesis and to the low level of GFP expression mediated by Ad11pe3GFP. Moreover, our results revealed that undetectable hexon protein hampered the assembly of virus particles in CHO and MDCK cells. Ad11p differed from Ad5 in the ability for viral DNA synthesis when infecting CHO cells. Although a defective Ad has been successfully developed for SARS-CoV-2 vaccines in clinical applications, it has been difficult to generate one that can be used as an oral SARS-CoV-2 vaccine. Fortunately, our replication-competent Ad 11p vector might solve this problem. Regarding the use of Ad-vector candidates for vaccine purposes, this study demonstrates the selection of animal cell lines and determination of suitable virus doses in in vitro experiments.", "doi": "10.3389/fmicb.2021.698999", "pmid": "34777270", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8578929"}], "notes": [], "created": "2021-11-26T14:27:58.792Z", "modified": "2021-11-26T14:27:58.830Z"}, {"entity": "publication", "iuid": "dc2be6dc17694aa697b4280a36f1bda0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dc2be6dc17694aa697b4280a36f1bda0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dc2be6dc17694aa697b4280a36f1bda0"}}, "title": "Structural Modeling on the Determinants of Effectiveness of SOPs Containing COVID-19 in Mass Gatherings.", "authors": [{"family": "Basit", "given": "Abdul", "initials": "A"}, {"family": "Scholz", "given": "Miklas", "initials": "M"}, {"family": "Niazi", "given": "Abdul Aziz Khan", "initials": "AAK"}, {"family": "Qazi", "given": "Tehmina Fiaz", "initials": "TF"}, {"family": "Shaukat", "given": "Muhammad Zeeshan", "initials": "MZ"}, {"family": "Rao", "given": "Zia-Ur-Rehman", "initials": "ZU"}, {"family": "Mahmood", "given": "Asif", "initials": "A"}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "755221", "issn-l": "1664-1078"}, "abstract": "The study is aimed to analyze the determinants of the effectiveness of SOPs in mass gatherings for containing COVID-19. The overall design of the study involves a literature review, data collection by field survey, structural modeling, and analysis. The study is built on the experts' opinion of a focus group (representing people who recently participated in and are responsible for mass gatherings). The study uses the discussion of the literature review to identify the determinants, interpretive structural modeling (ISM) for developing and analyzing a structural model, and Matrice d'Impacts Croises Multiplication Appliqu\u00e9e a un Classement (MICMAC) for corroboration of results of the ISM/classification of determinants. From the literature review, a list of determinants is generated and verified by a panel of experts. The results of the ISM revealed that the determinants \"legal environment of the country,\" \"practicability of SOPs,\" \"perceived benefit of adapting SOPs,\" and \"possibilities of avoiding gathering\" occupied the top of the model, therefore, they are less critical determinants, whereas \"nature of gathering\" occupied the bottom of the model, and is thus the most critical determinant. The remaining determinants form the middle of the model, and are therefore moderately severe. The results of MICMAC show that the determinant \"perceived benefit of adapting SOPs\" is dependent, \"nature of gathering\" is independent, and all others are linked. The results of MICMAC implicitly substantiate the findings of the ISM. The overall results of the study show that \"nature of gathering\" is the key determinant. This research does not require a priori theory since it is a theory-building study that uses an inductive approach. It is based on real data and it is useful for local authorities, organizers, participants (attendees/visitors) of mass gatherings, health officials/regulators, researchers, and the community at large. This study has fundamental importance for planning and preparing for such events while ensuring the minimum risk of COVID-19 transmission.", "doi": "10.3389/fpsyg.2021.755221", "pmid": "34777157", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC8578903"}], "notes": [], "created": "2021-11-26T14:28:19.315Z", "modified": "2021-11-26T14:28:19.329Z"}, {"entity": "publication", "iuid": "e5bae109b5e84a9687da1506ae5c14c8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e5bae109b5e84a9687da1506ae5c14c8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e5bae109b5e84a9687da1506ae5c14c8"}}, "title": "SARS-CoV-2 and pregnancy outcomes under universal and non-universal testing in Sweden: register-based nationwide cohort study.", "authors": [{"family": "Stephansson", "given": "Olof", "initials": "O"}, {"family": "Pasternak", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Ahlberg", "given": "Mia", "initials": "M"}, {"family": "Hervius Askling", "given": "Helena", "initials": "H"}, {"family": "Aronsson", "given": "Bernice", "initials": "B"}, {"family": "Appelqvist", "given": "Emma", "initials": "E"}, {"family": "Jonsson", "given": "Jerker", "initials": "J"}, {"family": "Sengpiel", "given": "Verena", "initials": "V"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Norman", "given": "Mikael", "initials": "M"}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}, {"family": "Neovius", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "BJOG", "issn": "1471-0528", "issn-l": null}, "abstract": "To assess associations of SARS-CoV-2-infection and pregnancy outcomes considering testing policy and test-positivity-to-delivery-interval.\n\nNationwide cohort study.\n\nSweden.\n\nFrom the Pregnancy-Register we identified 88,593 singleton births, March 11, 2020-January 31, 2021, linked to data on SARS-CoV-2-positivity from the Public Health Agency, and information on neonatal care admission from the Neonatal Quality-Register. Adjusted odds ratios (aORs) were estimated stratified by testing-policy and test-positivity-to-delivery-interval.\n\n5-minute Apgar score, neonatal care admission, stillbirth and preterm birth.\n\nDuring pregnancy, SARS-CoV-2 test-positivity was 5.4% (794/14,665) under universal and 1.9% (1402/73,928) under non-universal testing. There were generally lower risks associated with SARS-CoV-2 under universal than non-universal testing. In women testing positive >10 days from delivery, generally no significant differences in risk were observed under either testing policy. Neonatal care admission was more common (15.3% vs. 8.0%; aOR 2.24, 1.62-3.11) in women testing positive \u226410 days before delivery under universal testing. There was no significant association with 5-minute Apgar score <7 (1.0% vs. 1.7%; aOR 0.64, 0.24-1.72) or stillbirth (0.3% vs. 0.4%; aOR 0.72, 0.10-5.20). Compared with term births (2.1%), test-positivity was higher in medically indicated preterm (5.7%; aOR 2.70, 1.60-4.58) but not significantly increased in spontaneous preterm birth (2.3%; aOR 1.12, 0.62-2.02).\n\nTesting policy and timing of test positivity impact associations between SARS-CoV-2 positivity and pregnancy outcomes. Under non-universal testing, women with complications near delivery are more likely to be tested than women without complications, thereby inflating any association with adverse pregnancy outcomes compared to findings under universal testing.", "doi": "10.1111/1471-0528.16990", "pmid": "34706148", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:45:48.410Z", "modified": "2021-11-01T19:45:54.393Z"}, {"entity": "publication", "iuid": "5924041381054e26b5f234589e3c0477", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5924041381054e26b5f234589e3c0477.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5924041381054e26b5f234589e3c0477"}}, "title": "NMR-Based Analysis of Nanobodies to SARS-CoV-2 Nsp9 Reveals a Possible Antiviral Strategy Against COVID-19.", "authors": [{"family": "Esposito", "given": "Gennaro", "initials": "G"}, {"family": "Hunashal", "given": "Yamanappa", "initials": "Y"}, {"family": "Percipalle", "given": "Mathias", "initials": "M"}, {"family": "Venit", "given": "Tomas", "initials": "T"}, {"family": "Dieng", "given": "Mame Massar", "initials": "MM"}, {"family": "Fogolari", "given": "Federico", "initials": "F"}, {"family": "Hassanzadeh", "given": "Gholamreza", "initials": "G"}, {"family": "Piano", "given": "Fabio", "initials": "F"}, {"family": "Gunsalus", "given": "Kristin C", "initials": "KC"}, {"family": "Idaghdour", "given": "Youssef", "initials": "Y"}, {"family": "Percipalle", "given": "Piergiorgio", "initials": "P"}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "Adv Biol (Weinh)", "issn": "2701-0198", "pages": "e2101113", "issn-l": null}, "abstract": "Following the entry into the host cell, SARS-CoV-2 replication is mediated by the replication transcription complex (RTC) assembled through a number of nonstructural proteins (Nsps). A monomeric form of Nsp9 is particularly important for RTC assembly and function. In the present study, 136 unique nanobodies targeting Nsp9 are generated. Several nanobodies belonging to different B-cell lineages are expressed, purified, and characterized. Results from immunoassays applied to purified Nsp9 and neat saliva from coronavirus disease (COVID-19) patients show that these nanobodies effectively and specifically recognize both recombinant and endogenous Nsp9. Nuclear magnetic resonance analyses supported by molecular dynamics reveal a composite Nsp9 oligomerization pattern and demonstrate that both nanobodies stabilize the tetrameric form of wild-type Nsp9 also identifying the epitopes on the tetrameric assembly. These results can have important implications in the potential use of these nanobodies to combat viral replication.", "doi": "10.1002/adbi.202101113", "pmid": "34705339", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:39:08.657Z", "modified": "2021-11-01T19:44:19.968Z"}, {"entity": "publication", "iuid": "49a2fc525b8946b7a7913b62b72d1849", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49a2fc525b8946b7a7913b62b72d1849.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49a2fc525b8946b7a7913b62b72d1849"}}, "title": "Infection of Brain Pericytes Underlying Neuropathology of COVID-19 Patients.", "authors": [{"family": "Bocci", "given": "Matteo", "initials": "M", "orcid": "0000-0002-8774-0006", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c3ba1259efde4518bcdb59555b8a536e.json"}}, {"family": "Oudenaarden", "given": "Clara", "initials": "C", "orcid": "0000-0002-5466-0755", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75886cf472ee4475b742994021bb64c8.json"}}, {"family": "S\u00e0enz-Sard\u00e0", "given": "Xavier", "initials": "X"}, {"family": "Simr\u00e9n", "given": "Joel", "initials": "J", "orcid": "0000-0001-5081-6604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00690c8e16a545aea824cdf580837500.json"}}, {"family": "Ed\u00e9n", "given": "Arvid", "initials": "A"}, {"family": "Sj\u00f6lund", "given": "Jonas", "initials": "J", "orcid": "0000-0002-6992-3415", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5bf3daabd44d45efa72697934ad730b7.json"}}, {"family": "M\u00f6ller", "given": "Christina", "initials": "C"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Englund", "given": "Elisabet", "initials": "E", "orcid": "0000-0002-2708-2443", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b5ac92c5d404356b843be1973ea4922.json"}}, {"family": "Pietras", "given": "Kristian", "initials": "K", "orcid": "0000-0001-6738-4705", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5d4c2cbb9ca49a7a9664c83e383c695.json"}}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "issn-l": null, "volume": "22", "issue": "21", "pages": "11622"}, "abstract": "A wide range of neurological manifestations have been associated with the development of COVID-19 following SARS-CoV-2 infection. However, the etiology of the neurological symptomatology is still largely unexplored. Here, we used state-of-the-art multiplexed immunostaining of human brains (n = 6 COVID-19, median age = 69.5 years; n = 7 control, median age = 68 years) and demonstrated that expression of the SARS-CoV-2 receptor ACE2 is restricted to a subset of neurovascular pericytes. Strikingly, neurological symptoms were exclusive to, and ubiquitous in, patients that exhibited moderate to high ACE2 expression in perivascular cells. Viral dsRNA was identified in the vascular wall and paralleled by perivascular inflammation, as signified by T cell and macrophage infiltration. Furthermore, fibrinogen leakage indicated compromised integrity of the blood-brain barrier. Notably, cerebrospinal fluid from additional 16 individuals (n = 8 COVID-19, median age = 67 years; n = 8 control, median age = 69.5 years) exhibited significantly lower levels of the pericyte marker PDGFR\u03b2 in SARS-CoV-2-infected cases, indicative of disrupted pericyte homeostasis. We conclude that pericyte infection by SARS-CoV-2 underlies virus entry into the privileged central nervous system space, as well as neurological symptomatology due to perivascular inflammation and a locally compromised blood-brain barrier.", "doi": "10.3390/ijms222111622", "pmid": "34769052", "labels": {"Type: Journal article": null, "Category: Health": null, "Funder: H2020": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC8583965"}, {"db": "pii", "key": "ijms222111622"}], "notes": [], "created": "2021-11-26T15:11:17.222Z", "modified": "2023-06-19T14:45:33.615Z"}, {"entity": "publication", "iuid": "4deb3e9fe22f428bb2a86ea93ae98cc8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4deb3e9fe22f428bb2a86ea93ae98cc8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4deb3e9fe22f428bb2a86ea93ae98cc8"}}, "title": "Experience of the COVID-19 pandemic as lived by patients with hip and knee osteoarthritis: an Italian qualitative study.", "authors": [{"family": "Battista", "given": "Simone", "initials": "S", "orcid": "0000-0002-7471-1951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/787958b5579949919d584b1ef60e6eb2.json"}}, {"family": "Dell'Isola", "given": "Andrea", "initials": "A", "orcid": "0000-0002-0319-458X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d8ea417b7c447f8bc4da9f47f9feb39.json"}}, {"family": "Manoni", "given": "Mattia", "initials": "M"}, {"family": "Englund", "given": "Martin", "initials": "M"}, {"family": "Palese", "given": "Alvisa", "initials": "A", "orcid": "0000-0002-3508-844X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea400153bf344f98a5e06367b0442e17.json"}}, {"family": "Testa", "given": "Marco", "initials": "M"}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "10", "pages": "e053194", "issn-l": "2044-6055"}, "abstract": "To examine the experience of the COVID-19 pandemic as lived by people with hip and knee osteoarthritis (OA), in Italy.\n\nA qualitative study based on semi-structured interviews.\n\nUrban and suburban areas in northern Italy.\n\nA total of 11 people with OA were enrolled through a purposeful sampling and completed the study.\n\nThe experience of Italian people with OA during the COVID-19 pandemic.\n\nFour themes were brought to the forefront from the analysis of the interviews. (1) Being Stressed for the Limited Social Interactions and for the Family Members at High Risk of Infection, as the interviewees were frustrated because they could not see their loved ones or felt a sense of apprehension for their relatives. (2) Recurring Strategies to Cope with the Pandemic such as an active acceptance towards the situation. (3) Being Limited in the Possibility of Undergoing OA Complementary Treatments and Other Routine Medical Visits. (4) Being Unaware of the Importance of Physical Activity as First-Line Interventions which was an attitude already present before the pandemic.\n\nThe COVID-19 pandemic and related restrictions impacted the quality of life and the care of individuals with hip and knee OA. The social sphere seemed to be the most hindered. However, the interviewees developed a good level of acceptance to deal with the pandemic. When it came to their care, they faced a delay of routine medical visits not related to OA and of other complementary treatments (eg, physical therapies) to manage OA. Finally, a controversial result that emerged from these interviews was that first-line interventions for OA (ie, therapeutic exercise) was not sought by the interviewees, regardless of the restrictions dictated by the pandemic. Policy-making strategies are thus necessary to support the awareness of the importance of such interventions.", "doi": "10.1136/bmjopen-2021-053194", "pmid": "34706962", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-053194"}, {"db": "pmc", "key": "PMC8551748"}], "notes": [], "created": "2021-11-01T19:47:22.538Z", "modified": "2021-11-01T19:47:22.639Z"}, {"entity": "publication", "iuid": "e510117a965e4b958a1a37c706e5f11e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e510117a965e4b958a1a37c706e5f11e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e510117a965e4b958a1a37c706e5f11e"}}, "title": "Brain MRI and neuropsychological findings at long-term follow-up after COVID-19 hospitalisation: an observational cohort study.", "authors": [{"family": "Hellgren", "given": "Lovisa", "initials": "L", "orcid": "0000-0003-4099-9456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45a3650707574e258665a54751ae26ba.json"}}, {"family": "Birberg Thornberg", "given": "Ulrika", "initials": "U"}, {"family": "Samuelsson", "given": "Kersti", "initials": "K"}, {"family": "Levi", "given": "Richard", "initials": "R"}, {"family": "Divanoglou", "given": "Anestis", "initials": "A"}, {"family": "Blystad", "given": "Ida", "initials": "I"}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "10", "pages": "e055164", "issn-l": "2044-6055"}, "abstract": "To report findings on brain MRI and neurocognitive function, as well as persisting fatigue at long-term follow-up after COVID-19 hospitalisation in patients identified as high risk for affection of the central nervous system.\n\nAmbidirectional observational cohort study.\n\nAll 734 patients from a regional population in Sweden with a laboratory-confirmed COVID-19 diagnosis admitted to hospital during the period 1 March to 31 May 2020.\n\nA subgroup (n=185) with persisting symptoms still interfering with daily life at a telephone follow-up 4 months after discharge were invited for a medical and neuropsychological evaluation. Thirty-five of those who were assessed with a neurocognitive test battery at the clinical visit, and presented a clinical picture concerning for COVID-19-related brain pathology, were further investigated by brain MRI.\n\nFindings on brain MRI, neurocognitive test results and reported fatigue.\n\nTwenty-five patients (71%) had abnormalities on MRI; multiple white matter lesions were the most common finding. Sixteen patients (46%) demonstrated impaired neurocognitive function, of which 10 (29%) had severe impairment. Twenty-six patients (74%) reported clinically significant fatigue. Patients with abnormalities on MRI had a lower Visuospatial Index (p=0.031) compared with the group with normal MRI findings.\n\nIn this group of patients selected to undergo MRI after a clinical evaluation, a majority of patients had abnormal MRI and/or neurocognitive test results. Abnormal findings were not restricted to patients with severe disease.", "doi": "10.1136/bmjopen-2021-055164", "pmid": "34706965", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-055164"}, {"db": "pmc", "key": "PMC8551746"}], "notes": [], "created": "2021-11-01T19:47:38.514Z", "modified": "2021-11-01T19:47:38.573Z"}, {"entity": "publication", "iuid": "8ea921e8ebb1479ca21c1bc2cb4a4aba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ea921e8ebb1479ca21c1bc2cb4a4aba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ea921e8ebb1479ca21c1bc2cb4a4aba"}}, "title": "The impact of a COVID-19 lockdown on work productivity under good and poor compliance.", "authors": [{"family": "Ohrnberger", "given": "Julius", "initials": "J"}, {"family": "Segal", "given": "Alexa Blair", "initials": "AB"}, {"family": "Forchini", "given": "Giovanni", "initials": "G"}, {"family": "Miraldo", "given": "Marisa", "initials": "M"}, {"family": "Skarp", "given": "Janetta", "initials": "J"}, {"family": "Nedjati-Gilani", "given": "Gemma", "initials": "G"}, {"family": "Laydon", "given": "Daniel J", "initials": "DJ"}, {"family": "Ghani", "given": "Azra", "initials": "A"}, {"family": "Ferguson", "given": "Neil M", "initials": "NM"}, {"family": "Hauck", "given": "Katharina", "initials": "K"}], "type": "journal article", "published": "2021-10-26", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": "31", "issue": "5", "pages": "1009-1015"}, "abstract": "In response to the COVID-19 pandemic, governments across the globe have imposed strict social distancing measures. Public compliance to such measures is essential for their success, yet the economic consequences of compliance are unknown. This is the first study to analyze the effects of good compliance compared with poor compliance to a COVID-19 suppression strategy (i.e. lockdown) on work productivity.\r\n\r\nWe estimate the differences in work productivity comparing a scenario of good compliance with one of poor compliance to the UK government COVID-19 suppression strategy. We use projections of the impact of the UK suppression strategy on mortality and morbidity from an individual-based epidemiological model combined with an economic model representative of the labour force in Wales and England.\r\n\r\nWe find that productivity effects of good compliance significantly exceed those of poor compliance and increase with the duration of the lockdown. After 3 months of the lockdown, work productivity in good compliance is \u00a3398.58 million higher compared with that of poor compliance; 75% of the differences is explained by productivity effects due to morbidity and non-health reasons and 25% attributed to avoided losses due to pre-mature mortality.\r\n\r\nGood compliance to social distancing measures exceeds positive economic effects, in addition to health benefits. This is an important finding for current economic and health policy. It highlights the importance to set clear guidelines for the public, to build trust and support for the rules and if necessary, to enforce good compliance to social distancing measures.", "doi": "10.1093/eurpub/ckab138", "pmid": "34358291", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6343457"}, {"db": "pmc", "key": "PMC8385936"}], "notes": [], "created": "2021-08-11T14:38:19.897Z", "modified": "2021-11-18T13:28:17.534Z"}, {"entity": "publication", "iuid": "386040da818e4b41895292a89e9a70d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/386040da818e4b41895292a89e9a70d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/386040da818e4b41895292a89e9a70d9"}}, "title": "Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure", "authors": [{"family": "Rando", "given": "Halie M", "initials": "HM", "orcid": "0000-0001-7688-1770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b5a9f4ec1bd48579abca9895dab3ea7.json"}}, {"family": "MacLean", "given": "Adam L", "initials": "AL"}, {"family": "Lee", "given": "Alexandra J", "initials": "AJ"}, {"family": "Lordan", "given": "Ronan", "initials": "R", "orcid": "0000-0001-9668-3368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0126a49dfcdf49fcb53041fbdcd91706.json"}}, {"family": "Ray", "given": "Sandipan", "initials": "S"}, {"family": "Bansal", "given": "Vikas", "initials": "V"}, {"family": "Skelly", "given": "Ashwin N", "initials": "AN"}, {"family": "Sell", "given": "Elizabeth", "initials": "E"}, {"family": "Dziak", "given": "John J", "initials": "JJ"}, {"family": "Shinholster", "given": "Lamonica", "initials": "L"}, {"family": "D\u2019Agostino McGowan", "given": "Lucy", "initials": "L"}, {"family": "Ben Guebila", "given": "Marouen", "initials": "M"}, {"family": "Wellhausen", "given": "Nils", "initials": "N"}, {"family": "Knyazev", "given": "Sergey", "initials": "S"}, {"family": "Boca", "given": "Simina M", "initials": "SM"}, {"family": "Capone", "given": "Stephen", "initials": "S"}, {"family": "Qi", "given": "Yanjun", "initials": "Y"}, {"family": "Park", "given": "YoSon", "initials": "Y"}, {"family": "Mai", "given": "David", "initials": "D"}, {"family": "Sun", "given": "Yuchen", "initials": "Y"}, {"family": "Boerckel", "given": "Joel D", "initials": "JD"}, {"family": "Brueffer", "given": "Christian", "initials": "C"}, {"family": "Byrd", "given": "James Brian", "initials": "JB"}, {"family": "Kamil", "given": "Jeremy P", "initials": "JP", "orcid": "0000-0001-8422-7656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa225803435a4d7b803176e2ccfbef19.json"}}, {"family": "Wang", "given": "Jinhui", "initials": "J"}, {"family": "Velazquez", "given": "Ryan", "initials": "R"}, {"family": "Szeto", "given": "Gregory L", "initials": "GL"}, {"family": "Barton", "given": "John P", "initials": "JP"}, {"family": "Goel", "given": "Rishi Raj", "initials": "RR"}, {"family": "Mangul", "given": "Serghei", "initials": "S"}, {"family": "Lubiana", "given": "Tiago", "initials": "T"}, {"family": "Gitter", "given": "Anthony", "initials": "A"}, {"family": "Greene", "given": "Casey S", "initials": "CS", "orcid": "0000-0001-8713-9213", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42aaaac8b65642538f28f9cd2045ab8d.json"}}, {"family": "None", "given": "", "initials": ""}], "type": "journal-article", "published": "2021-10-26", "journal": {"title": "mSystems", "issn": "2379-5077", "issn-l": null, "volume": "6", "issue": "5", "pages": null}, "abstract": null, "doi": "10.1128/msystems.00095-21", "pmid": null, "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:37:06.978Z", "modified": "2021-11-18T14:28:27.267Z"}, {"entity": "publication", "iuid": "70243d223f1848d1967e89a92973652a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70243d223f1848d1967e89a92973652a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70243d223f1848d1967e89a92973652a"}}, "title": "Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms.", "authors": [{"family": "Zhu", "given": "Rongjia", "initials": "R", "orcid": "0000-0003-3165-2813", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6f44e080388045cfb694fe567aa26b16.json"}}, {"family": "Yan", "given": "Tingdong", "initials": "T"}, {"family": "Feng", "given": "Yingmei", "initials": "Y", "orcid": "0000-0001-5248-0155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975beb8e77c84ab1b4de7b8faaf1c24b.json"}}, {"family": "Liu", "given": "Yan", "initials": "Y"}, {"family": "Cao", "given": "Hongcui", "initials": "H", "orcid": "0000-0002-6604-6867", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2296fd365154488bba2c052485f370d0.json"}}, {"family": "Peng", "given": "Gongxin", "initials": "G"}, {"family": "Yang", "given": "Yanlei", "initials": "Y"}, {"family": "Xu", "given": "Zhen", "initials": "Z"}, {"family": "Liu", "given": "Jingqi", "initials": "J"}, {"family": "Hou", "given": "Wei", "initials": "W"}, {"family": "Wang", "given": "Xiaoyue", "initials": "X"}, {"family": "Li", "given": "Zhe", "initials": "Z"}, {"family": "Deng", "given": "Luchan", "initials": "L"}, {"family": "Wang", "given": "Shihua", "initials": "S"}, {"family": "Li", "given": "Jing", "initials": "J"}, {"family": "Han", "given": "Qin", "initials": "Q"}, {"family": "Li", "given": "Hongling", "initials": "H"}, {"family": "Shan", "given": "Guangliang", "initials": "G"}, {"family": "Cao", "given": "Yinghao", "initials": "Y"}, {"family": "An", "given": "Xingyan", "initials": "X"}, {"family": "Yan", "given": "Jianshe", "initials": "J"}, {"family": "Zhang", "given": "Zhonghui", "initials": "Z"}, {"family": "Li", "given": "Huafei", "initials": "H"}, {"family": "Qu", "given": "Xuebin", "initials": "X"}, {"family": "Zhu", "given": "Jiaqi", "initials": "J"}, {"family": "Zhou", "given": "Shumin", "initials": "S"}, {"family": "Wang", "given": "Jiao", "initials": "J"}, {"family": "Zhang", "given": "Fengchun", "initials": "F"}, {"family": "Gao", "given": "Jinming", "initials": "J"}, {"family": "Jin", "given": "Ronghua", "initials": "R", "orcid": "0000-0002-6035-2425", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af992bd4085247d68012ae3996daa0bd.json"}}, {"family": "Xu", "given": "Dayong", "initials": "D"}, {"family": "Ma", "given": "Yan-Qing", "initials": "YQ", "orcid": "0000-0002-0573-7701", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b1665bdbfe34e6ca10bbd4dfd63470f.json"}}, {"family": "Huang", "given": "Tao", "initials": "T"}, {"family": "Peng", "given": "Shuang", "initials": "S"}, {"family": "Zheng", "given": "Zhi", "initials": "Z"}, {"family": "Stambler", "given": "Ilia", "initials": "I"}, {"family": "Gilson", "given": "Eric", "initials": "E"}, {"family": "Lim", "given": "Lee Wei", "initials": "LW"}, {"family": "Moskalev", "given": "Alexey", "initials": "A", "orcid": "0000-0002-3248-1633", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18eb8535023143ee9ec9f80ca3dc7185.json"}}, {"family": "Cano", "given": "Antonio", "initials": "A"}, {"family": "Chakrabarti", "given": "Sasanka", "initials": "S"}, {"family": "Ulfhake", "given": "Brun", "initials": "B"}, {"family": "Su", "given": "Huanxing", "initials": "H"}, {"family": "Xu", "given": "Haoying", "initials": "H"}, {"family": "Xu", "given": "Sihuan", "initials": "S"}, {"family": "Wei", "given": "Feng", "initials": "F"}, {"family": "Brown-Borg", "given": "Holly M", "initials": "HM"}, {"family": "Min", "given": "Kyung-Jin", "initials": "KJ"}, {"family": "Ellison-Hughes", "given": "Georgina", "initials": "G"}, {"family": "Caruso", "given": "Calogero", "initials": "C"}, {"family": "Jin", "given": "Kunlin", "initials": "K"}, {"family": "Zhao", "given": "Robert Chunhua", "initials": "RC", "orcid": "0000-0002-4609-8424", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d1fca3775f643f9992e48a753ca1a37.json"}}], "type": "journal article", "published": "2021-10-26", "journal": {"title": "Cell Res", "issn": "1748-7838", "issn-l": null}, "abstract": "The infusion of coronavirus disease 2019 (COVID-19) patients with mesenchymal stem cells (MSCs) potentially improves clinical symptoms, but the underlying mechanism remains unclear. We conducted a randomized, single-blind, placebo-controlled (29 patients/group) phase II clinical trial to validate previous findings and explore the potential mechanisms. Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay (P = 0.0198) and less time required for symptoms remission (P = 0.0194) than those who received placebo. Based on chest images, both severe and critical patients treated with MSCs showed improvement by day 7 (P = 0.0099) and day 21 (P = 0.0084). MSC-treated patients had fewer adverse events. MSC infusion reduced the levels of C-reactive protein, proinflammatory cytokines, and neutrophil extracellular traps (NETs) and promoted the maintenance of SARS-CoV-2-specific antibodies. To explore how MSCs modulate the immune system, we employed single-cell RNA sequencing analysis on peripheral blood. Our analysis identified a novel subpopulation of VNN2+ hematopoietic stem/progenitor-like (HSPC-like) cells expressing CSF3R and PTPRE that were mobilized following MSC infusion. Genes encoding chemotaxis factors - CX3CR1 and L-selectin - were upregulated in various immune cells. MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro. In addition, an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling. Together, our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis.", "doi": "10.1038/s41422-021-00573-y", "pmid": "34702946", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41422-021-00573-y"}, {"db": "pmc", "key": "PMC8546390"}], "notes": [], "created": "2021-11-01T19:40:40.141Z", "modified": "2021-11-01T19:40:40.407Z"}, {"entity": "publication", "iuid": "c91b5940918046b7b7baf2c3432e336b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c91b5940918046b7b7baf2c3432e336b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c91b5940918046b7b7baf2c3432e336b"}}, "title": "Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort", "authors": [{"family": "Carapito", "given": "Raphael", "initials": "R"}, {"family": "Li", "given": "Richard", "initials": "R"}, {"family": "Helms", "given": "Julie", "initials": "J"}, {"family": "Carapito", "given": "Christine", "initials": "C"}, {"family": "Gujja", "given": "Sharvari", "initials": "S"}, {"family": "Rolli", "given": "V\u00e9ronique", "initials": "V"}, {"family": "Guimaraes", "given": "Raony", "initials": "R"}, {"family": "Malagon-Lopez", "given": "Jose", "initials": "J"}, {"family": "Spinnhirny", "given": "Perrine", "initials": "P"}, {"family": "Lederle", "given": "Alexandre", "initials": "A"}, {"family": "Mohseninia", "given": "Razieh", "initials": "R"}, {"family": "Hirschler", "given": "Aur\u00e9lie", "initials": "A"}, {"family": "Muller", "given": "Leslie", "initials": "L"}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Gervais", "given": "Adrian", "initials": "A"}, {"family": "Zhang", "given": "Qian", "initials": "Q"}, {"family": "Danion", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Ruch", "given": "Yvon", "initials": "Y"}, {"family": "Schenck", "given": "Maleka", "initials": "M"}, {"family": "Collange", "given": "Olivier", "initials": "O"}, {"family": "Chamaraux-Tran", "given": "Thi\u00ean Nga", "initials": "TN"}, {"family": "Molitor", "given": "Anne", "initials": "A"}, {"family": "Pichot", "given": "Ang\u00e9lique", "initials": "A"}, {"family": "Bernard", "given": "Alice", "initials": "A"}, {"family": "Tahar", "given": "Ouria", "initials": "O"}, {"family": "Bibi-Triki", "given": "Sabrina", "initials": "S"}, {"family": "Wu", "given": "Haiguo", "initials": "H"}, {"family": "Paul", "given": "Nicod\u00e8me", "initials": "N"}, {"family": "Mayeur", "given": "Sylvain", "initials": "S"}, {"family": "Larnicol", "given": "Annabel", "initials": "A"}, {"family": "Laumond", "given": "G\u00e9raldine", "initials": "G"}, {"family": "Frappier", "given": "Julia", "initials": "J"}, {"family": "Schmidt", "given": "Sylvie", "initials": "S"}, {"family": "Hanauer", "given": "Antoine", "initials": "A"}, {"family": "Macquin", "given": "C\u00e9cile", "initials": "C"}, {"family": "Stemmelen", "given": "Tristan", "initials": "T"}, {"family": "Simons", "given": "Michael", "initials": "M"}, {"family": "Mariette", "given": "Xavier", "initials": "X"}, {"family": "Hermine", "given": "Olivier", "initials": "O"}, {"family": "Fafi-Kremer", "given": "Samira", "initials": "S"}, {"family": "Goichot", "given": "Bernard", "initials": "B"}, {"family": "Drenou", "given": "Bernard", "initials": "B"}, {"family": "Kuteifan", "given": "Khaldoun", "initials": "K"}, {"family": "Pottecher", "given": "Julien", "initials": "J"}, {"family": "Mertes", "given": "Paul Michel", "initials": "PM"}, {"family": "Kailasan", "given": "Shweta", "initials": "S"}, {"family": "Aman", "given": "M Javad", "initials": "MJ"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Thomas", "given": "Anne", "initials": "A"}, {"family": "Viari", "given": "Alain", "initials": "A"}, {"family": "Sanlaville", "given": "Damien", "initials": "D"}, {"family": "Schneider", "given": "Francis", "initials": "F"}, {"family": "Sibilia", "given": "Jean", "initials": "J"}, {"family": "Tharaux", "given": "Pierre Louis", "initials": "PL"}, {"family": "Casanova", "given": "Jean Laurent", "initials": "JL"}, {"family": "Hansmann", "given": "Yves", "initials": "Y"}, {"family": "Lidar", "given": "Daniel", "initials": "D"}, {"family": "Radosavljevic", "given": "Mirjana", "initials": "M"}, {"family": "Gulcher", "given": "Jeffrey R", "initials": "JR"}, {"family": "Meziani", "given": "Ferhat", "initials": "F"}, {"family": "Moog", "given": "Christiane", "initials": "C"}, {"family": "Chittenden", "given": "Thomas W", "initials": "TW"}, {"family": "Bahram", "given": "Seiamak", "initials": "S"}], "type": "journal-article", "published": "2021-10-26", "journal": {"title": "Sci. Transl. Med.", "issn": "1946-6234", "pages": "eabj7521", "issn-l": null}, "abstract": "[Figure: see text].", "doi": "10.1126/scitranslmed.abj7521", "pmid": "34698500", "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "GEO", "key": "GSE172114", "description": "RNA-seq datasets"}, {"db": "URL", "key": "http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD025265", "description": "Proteomics data are available in the ProteomeXchange Consortium database (identifier PXD025265)"}, {"db": "URL", "key": "https://zenodo.org/record/5557611#.YZZcmC8w3OQ", "description": "Codes used for analysis"}], "notes": [], "created": "2021-10-26T18:35:08.060Z", "modified": "2021-11-18T16:24:43.998Z"}, {"entity": "publication", "iuid": "fa8cdbf2d54240edb509d2e0799d6ae8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa8cdbf2d54240edb509d2e0799d6ae8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa8cdbf2d54240edb509d2e0799d6ae8"}}, "title": "GRAd-COV2, a gorilla adenovirus-based candidate vaccine against COVID-19, is safe and immunogenic in younger and older adults", "authors": [{"family": "Lanini", "given": "Simone", "initials": "S"}, {"family": "Capone", "given": "Stefania", "initials": "S"}, {"family": "Antinori", "given": "Andrea", "initials": "A"}, {"family": "Milleri", "given": "Stefano", "initials": "S"}, {"family": "Nicastri", "given": "Emanuele", "initials": "E"}, {"family": "Camerini", "given": "Roberto", "initials": "R"}, {"family": "Agrati", "given": "Chiara", "initials": "C"}, {"family": "Castilletti", "given": "Concetta", "initials": "C"}, {"family": "Mori", "given": "Federica", "initials": "F"}, {"family": "Sacchi", "given": "Alessandra", "initials": "A"}, {"family": "Matusali", "given": "Giulia", "initials": "G"}, {"family": "Gagliardini", "given": "Roberta", "initials": "R"}, {"family": "Ammendola", "given": "Virginia", "initials": "V"}, {"family": "Cimini", "given": "Eleonora", "initials": "E"}, {"family": "Grazioli", "given": "Fabiana", "initials": "F"}, {"family": "Scorzolini", "given": "Laura", "initials": "L"}, {"family": "Napolitano", "given": "Federico", "initials": "F"}, {"family": "Plazzi", "given": "Maria M", "initials": "MM"}, {"family": "Soriani", "given": "Marco", "initials": "M"}, {"family": "De Luca", "given": "Aldo", "initials": "A"}, {"family": "Battella", "given": "Simone", "initials": "S"}, {"family": "Sommella", "given": "Andrea", "initials": "A"}, {"family": "Contino", "given": "Alessandra M", "initials": "AM"}, {"family": "Barra", "given": "Federica", "initials": "F"}, {"family": "Gentile", "given": "Michela", "initials": "M"}, {"family": "Raggioli", "given": "Angelo", "initials": "A"}, {"family": "Shi", "given": "Yufang", "initials": "Y"}, {"family": "Girardi", "given": "Enrico", "initials": "E"}, {"family": "Maeurer", "given": "Markus", "initials": "M"}, {"family": "Capobianchi", "given": "Maria R", "initials": "MR"}, {"family": "Vaia", "given": "Francesco", "initials": "F"}, {"family": "Piacentini", "given": "Mauro", "initials": "M"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}, {"family": "Vitelli", "given": "Alessandra", "initials": "A"}, {"family": "Colloca", "given": "Stefano", "initials": "S"}, {"family": "Folgori", "given": "Antonella", "initials": "A"}, {"family": "Ippolito", "given": "Giuseppe", "initials": "G"}, {"family": "Ottou", "given": "Sandrine", "initials": "S"}, {"family": "Vita", "given": "Serena", "initials": "S"}, {"family": "Vergori", "given": "Alessandra", "initials": "A"}, {"family": "D\u2019Abramo", "given": "Alessandra", "initials": "A"}, {"family": "Petrecchia", "given": "Antonella", "initials": "A"}, {"family": "Montaldo", "given": "Chiara", "initials": "C"}, {"family": "Scalise", "given": "Emilio", "initials": "E"}, {"family": "Grassi", "given": "Germana", "initials": "G"}, {"family": "Casetti", "given": "Rita", "initials": "R"}, {"family": "Bordoni", "given": "Veronica", "initials": "V"}, {"family": "Notari", "given": "Stefania", "initials": "S"}, {"family": "Colavita", "given": "Francesca", "initials": "F"}, {"family": "Meschi", "given": "Silvia", "initials": "S"}, {"family": "Lapa", "given": "Daniele", "initials": "D"}, {"family": "Bordi", "given": "Licia", "initials": "L"}, {"family": "Murachelli", "given": "Silvia", "initials": "S"}, {"family": "Tambasco", "given": "Teresa", "initials": "T"}, {"family": "Grillo", "given": "Alessandra", "initials": "A"}, {"family": "Masone", "given": "Erminia", "initials": "E"}, {"family": "Marchioni", "given": "Elisa", "initials": "E"}, {"family": "Bardhi", "given": "Dorian", "initials": "D"}, {"family": "Porzio", "given": "Ottavia", "initials": "O"}, {"family": "Cocca", "given": "Francesca", "initials": "F"}, {"family": "Murachelli", "given": "Silvia", "initials": "S"}, {"family": "Turrini", "given": "Irene", "initials": "I"}, {"family": "Malescio", "given": "Feliciana", "initials": "F"}, {"family": "Ziviani", "given": "Luigi", "initials": "L"}, {"family": "Lawlor", "given": "Rita", "initials": "R"}, {"family": "Poli", "given": "Federica", "initials": "F"}, {"family": "Martire", "given": "Federica", "initials": "F"}, {"family": "Zamboni", "given": "Daniela", "initials": "D"}, {"family": "Mazzaferri", "given": "Flavia", "initials": "F"}], "type": "journal-article", "published": "2021-10-26", "journal": {"title": "Sci. Transl. Med.", "issn": "1946-6234", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1126/scitranslmed.abj1996", "pmid": "34698501", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:36:34.474Z", "modified": "2021-11-29T06:07:56.622Z"}, {"entity": "publication", "iuid": "c918a56ef26044f7af5082f1360adfd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c918a56ef26044f7af5082f1360adfd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c918a56ef26044f7af5082f1360adfd0"}}, "title": "A more frequent disease monitorering but no increased disease activity in patients with inflammatory bowel disease during the first year of the SARS-CoV-2 pandemic. A retrospective study.", "authors": [{"family": "Lindhagen", "given": "Sara", "initials": "S"}, {"family": "Karling", "given": "Pontus", "initials": "P", "orcid": "0000-0002-5607-0118", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e40faefd22e41449b1a7d717efead99.json"}}], "type": "journal article", "published": "2021-10-26", "journal": {"title": "Scand J Gastroenterol", "issn": "1502-7708", "pages": "1-6", "issn-l": null}, "abstract": "The SARS-CoV-2 pandemic abruptly switched the healthcare service for patients with inflammatory bowel disease (IBD) towards a telemedicine dominated approach. The aim of this study was to investigate the impact of this switch on monitoring of patients and on disease activity.\n\nThe pre-pandemic year included 868 patients and the first year of the pandemic included 891 patients. Medical records were retrospectively checked for contacts, changes in medical treatment, performed fecal calprotectin (FC) tests and colonoscopies.\n\nThe scheduled follow-up visits to a doctor for patients with IBD shifted from mostly face-to-face pre-pandemic (from 389 to 118 appointments) to mostly telephone-based during the pandemic (from 13 to 423 appointments). There was a 21.3% increase in mean overall scheduled health contacts (p < .001) and a 20.0% increase for the mean number of FC tests (p < .001) in the year of the pandemic compared to the pre-pandemic year. The proportion of patients who had a surveillance colonoscopy was significant lower in the year of the pandemic compared to the pre-pandemic year (12.7% vs 20.1%; p = .002). There were no difference in the proportion of patients with a median FC > 200 mg/kg (18.2% vs 17.1%; p = .767) and in the proportion of patients who changed their medical treatment (24.7% vs 23.9%; p = .713) in the first year of the pandemic compared to the prepandemic year.\n\nThe shift towards a telemedicine oriented IBD healthcare service in the first year of the pandemic significantly increased the scheduled contacts, as well as the frequency of FC testing. However, there was a significant decrease in performed surveillance colonoscopies. Between the two periods observed, the patients showed no difference in medical treatment or in disease activity.", "doi": "10.1080/00365521.2021.1993328", "pmid": "34699290", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-27T05:07:31.917Z", "modified": "2021-10-27T05:07:46.378Z"}, {"entity": "publication", "iuid": "0b8c088789ae4f52b144b57d5b341d3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b8c088789ae4f52b144b57d5b341d3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b8c088789ae4f52b144b57d5b341d3d"}}, "title": "Telemedicine as an alternative way to access abortion in Italy and characteristics of requests during the COVID-19 pandemic", "authors": [{"family": "Brandell", "given": "Karin", "initials": "K", "orcid": "0000-0003-0548-3374", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8948d3105df4faaa867b27a1fb3d4ed.json"}}, {"family": "Vanbenschoten", "given": "Hannah", "initials": "H"}, {"family": "Parachini", "given": "Mirella", "initials": "M"}, {"family": "Gomperts", "given": "Rebecca", "initials": "R"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}], "type": "journal-article", "published": "2021-10-25", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-1991", "pages": "bmjsrh-2021-201281", "issn-l": null}, "abstract": null, "doi": "10.1136/bmjsrh-2021-201281", "pmid": null, "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:32:18.606Z", "modified": "2021-10-26T18:32:18.674Z"}, {"entity": "publication", "iuid": "66ddd8c7d6ab449e9cfff0cbc669e25b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66ddd8c7d6ab449e9cfff0cbc669e25b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66ddd8c7d6ab449e9cfff0cbc669e25b"}}, "title": "Synchronization in epidemic growth and the impossibility of selective containment.", "authors": [{"family": "Budich", "given": "Jan C", "initials": "JC"}, {"family": "Bergholtz", "given": "Emil J", "initials": "EJ"}], "type": "journal article", "published": "2021-10-25", "journal": {"title": "Math Med Biol", "issn": "1477-8602", "issn-l": null}, "abstract": "Containment, aiming to prevent the epidemic stage of community-spreading altogether, and mitigation, aiming to merely 'flatten the curve' of a wide-ranged outbreak, constitute two qualitatively different approaches to combating an epidemic through non-pharmaceutical interventions. Here, we study a simple model of epidemic dynamics separating the population into two groups, namely a low-risk group and a high-risk group, for which different strategies are pursued. Due to synchronization effects, we find that maintaining a slower epidemic growth behaviour for the high-risk group is unstable against any finite coupling between the two groups. More precisely, the density of infected individuals in the two groups qualitatively evolves very similarly, apart from a small time delay and an overall scaling factor quantifying the coupling between the groups. Hence, selective containment of the epidemic in a targeted (high-risk) group is practically impossible whenever the surrounding society implements a mitigated community-spreading. We relate our general findings to the ongoing COVID-19 pandemic.", "doi": "10.1093/imammb/dqab013", "pmid": "34695187", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6409757"}], "notes": [], "created": "2021-10-26T18:28:24.487Z", "modified": "2021-10-26T18:28:24.523Z"}, {"entity": "publication", "iuid": "0f3f009975074859a7e934f2272ba059", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0f3f009975074859a7e934f2272ba059.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0f3f009975074859a7e934f2272ba059"}}, "title": "Deviant Swedes in the Global Covid-19 Media Environment", "authors": [{"family": "Irwin", "given": "Rachel E", "initials": "RE"}], "type": "journal-article", "published": "2021-10-25", "journal": {"title": "Medical Anthropology", "issn": "0145-9740", "pages": "1-15", "issn-l": null}, "abstract": null, "doi": "10.1080/01459740.2021.1988594", "pmid": null, "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:32:03.030Z", "modified": "2021-10-26T18:32:03.067Z"}, {"entity": "publication", "iuid": "2664b49079004ce3ab5f1bbf0f59e1df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2664b49079004ce3ab5f1bbf0f59e1df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2664b49079004ce3ab5f1bbf0f59e1df"}}, "title": "Consequences of the Covid-19 virus on individuals receiving homecare services in Norway. A qualitative study of nursing students' reflective notes.", "authors": [{"family": "Eide", "given": "Leslie S P", "initials": "LSP"}, {"family": "Giske", "given": "Tove", "initials": "T"}, {"family": "Kuven", "given": "Britt Moene", "initials": "BM"}, {"family": "Johansson", "given": "Linda", "initials": "L"}], "type": "journal article", "published": "2021-10-25", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "issn-l": null, "volume": "20", "issue": "1", "pages": "208"}, "abstract": "Reflective notes in nursing education can facilitate students' understanding of how individuals in need of home healthcare services experience unfamiliar situations, such as a pandemic. The aim of this study is to describe the consequences of the COVID-19 virus for individuals receiving homecare services through the eyes of nursing students.\r\n\r\nThis is a qualitative descriptive study using content analysis to examine reflection notes from 17 nursing students in their last year of academic studies while undertaking home healthcare service training.\r\n\r\nOur study shows students' reflections on the consequences of the COVID-19 virus on individuals needing home healthcare services and their families. The analysis reveals three categories that described the effect of the virus according to students' reflections: i) how social life became restricted and only includes the closest family members and home healthcare staff (declining social circle), ii) how family members take on more responsibility to care for the individual and the pronounced impact of this on the day-to-day lives of the individual's next of kin (expanding responsibility of care), and iii) actions and reactions related to preventing the spread of the virus (dealing with the invisible threat).\r\n\r\nStudents' reflection notes show that COVID-19 had major consequences, not only on the individuals receiving home healthcare services, but also on their relatives and on home healthcare staff.", "doi": "10.1186/s12912-021-00732-x", "pmid": "34689756", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12912-021-00732-x"}], "notes": [], "created": "2021-10-26T18:20:20.104Z", "modified": "2022-02-17T12:19:36.937Z"}, {"entity": "publication", "iuid": "c47d5d1ccea24687a1359fc194361747", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c47d5d1ccea24687a1359fc194361747.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c47d5d1ccea24687a1359fc194361747"}}, "title": "Factors related to preventive COVID-19 behaviors using health belief model among general population: a cross-sectional study in Iran.", "authors": [{"family": "Karimy", "given": "Mahmood", "initials": "M"}, {"family": "Bastami", "given": "Fatemeh", "initials": "F"}, {"family": "Sharifat", "given": "Robab", "initials": "R"}, {"family": "Heydarabadi", "given": "Akbar Babaei", "initials": "AB"}, {"family": "Hatamzadeh", "given": "Naser", "initials": "N"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Cheraghian", "given": "Bahman", "initials": "B"}, {"family": "Zamani-Alavijeh", "given": "Fereshteh", "initials": "F"}, {"family": "Jasemzadeh", "given": "Mehrnoosh", "initials": "M"}, {"family": "Araban", "given": "Marzieh", "initials": "M", "orcid": "0000-0001-9920-0261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/267b131c24034c33b0ddff1b97f316a5.json"}}], "type": "journal article", "published": "2021-10-24", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "21", "issue": "1", "pages": "1934", "issn-l": null}, "abstract": "Coronavirus disease (COVID-19) pandemic has become one of the biggest challenges to global health and economy. The present study aimed to explore the factors related to preventive health behaviors during the COVID-19 pandemic in Khuzestan Province, South of Iran, using the Health Belief Model (HBM).\n\nThe present cross-sectional study was conducted in the period between July 2020 and September 2020. A total of 1090 people from Khuzestan province participated in the study. The data collection method included a multistage cluster sampling method with a random selection of provincial of health centers. The questionnaire collected socio-demographic information and HBM constructs (e.g., perceived susceptibility, perceived severity, perceived benefits and barriers, cues to action, and COVID-19 preventive behaviors). Data were analyzed using ANOVA, t-test, hierarchical multiple linear regression, and SPSS version 22.\n\nThe mean age of the participants was 35.53 \u00b1 11.53, more than half of them were female (61.6%) and married (65.3). The results showed that 27% of the variance in the COVID-19 preventive behaviors was explained by HBM constructs. The regression analysis indicated that female gender (\u03b2 = 0.11), perceived benefits (\u03b2 = 0.10), perceived barriers (\u03b2 = - 0.18), external cues to action (\u03b2 = 0.25), and internal cues to action (\u03b2 = 0.12) were significantly associated with COVID-19 preventive behaviors (p < 0.05).\n\nDesigning an educational intervention on the basis of HBM might be considered as a framework for the correction of beliefs and adherence to COVID-19 behavior. Health information campaigns need to (1) emphasize the benefits of preventive behaviors including avoiding the likelihood of getting a chronic disease and complications of the disease, (2) highlight the tips and advice to overcome the barriers (3) provide cues to action by means of showing various reminders in social media (4) focusing on adoption of COVID-19-related preventive behaviors, especially among men.", "doi": "10.1186/s12889-021-11983-3", "pmid": "34689728", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11983-3"}], "notes": [], "created": "2021-10-26T18:19:52.461Z", "modified": "2021-10-26T18:20:04.121Z"}, {"entity": "publication", "iuid": "753088ac0907438a849b4b5a119ed2cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/753088ac0907438a849b4b5a119ed2cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/753088ac0907438a849b4b5a119ed2cb"}}, "title": "X-Linked TLR7 Deficiency Underlies Critical COVID-19 Pneumonia in a Male Patient with Ataxia-Telangiectasia.", "authors": [{"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Vosughimotlagh", "given": "Ahmad", "initials": "A"}, {"family": "Asano", "given": "Takaki", "initials": "T"}, {"family": "Landegren", "given": "Nils", "initials": "N"}, {"family": "Boisson", "given": "Bertrand", "initials": "B"}, {"family": "Delavari", "given": "Samaneh", "initials": "S"}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Aranda-Guill\u00e9n", "given": "Maribel", "initials": "M"}, {"family": "Wang", "given": "Yating", "initials": "Y"}, {"family": "Zuo", "given": "Fanglei", "initials": "F"}, {"family": "Sardh", "given": "Fabian", "initials": "F"}, {"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Zhang", "given": "Qian", "initials": "Q"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q", "orcid": "0000-0003-1990-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94a32366862b470eba3a15521b9be290.json"}}], "type": "journal article", "published": "2021-10-23", "journal": {"title": "J Clin Immunol", "issn": "1573-2592", "issn-l": "0271-9142"}, "abstract": "Coronavirus disease 2019 (COVID-19) exhibits a wide spectrum of clinical manifestations, ranging from asymptomatic to critical conditions. Understanding the mechanism underlying life-threatening COVID-19 is instrumental for disease prevention and treatment in individuals with a high risk.\n\nWe aimed to identify the genetic cause for critical COVID-19 pneumonia in a patient with a preexisting inborn error of immunity (IEI).\n\nSerum levels of specific antibodies against the virus and autoantibodies against type I interferons (IFNs) were measured. Whole exome sequencing was performed, and the impacts of candidate gene variants were investigated. We also evaluated 247 ataxia-telangiectasia (A-T) patients in the Iranian IEI registry.\n\nWe report a 7-year-old Iranian boy with a preexisting hyper IgM syndrome who developed critical COVID-19 pneumonia. IgM only specific COVID-19 immune response was detected but no autoantibodies against type I IFN were observed. A homozygous deleterious mutation in the ATM gene was identified, which together with his antibody deficiency, radiosensitivity, and neurological signs, established a diagnosis of A-T. Among the 247 A-T patients evaluated, 36 had SARS-CoV-2 infection, but all had mild symptoms or were asymptomatic except the index patient. A hemizygous deleterious mutation in the TLR7 gene was subsequently identified in the patient.\n\nWe report a unique IEI patient with combined ATM and TLR7 deficiencies. The two genetic defects underlie A-T and critical COVID-19 in this patient, respectively.", "doi": "10.1007/s10875-021-01151-y", "pmid": "34686943", "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10875-021-01151-y"}, {"db": "pmc", "key": "PMC8536475"}], "notes": [], "created": "2021-10-26T18:18:29.681Z", "modified": "2021-11-18T15:08:59.029Z"}, {"entity": "publication", "iuid": "13be130c39184985887399e1f4a8c94e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13be130c39184985887399e1f4a8c94e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13be130c39184985887399e1f4a8c94e"}}, "title": "Potential therapeutic effect of oxygen-ozone in controlling of COVID-19 disease.", "authors": [{"family": "Yousefi", "given": "Bahman", "initials": "B"}, {"family": "Banihashemian", "given": "Seyedeh Zahra", "initials": "SZ"}, {"family": "Feyzabadi", "given": "Zahra Khatibiyan", "initials": "ZK"}, {"family": "Hasanpour", "given": "Sahar", "initials": "S"}, {"family": "Kokhaei", "given": "Parviz", "initials": "P"}, {"family": "Abdolshahi", "given": "Anna", "initials": "A"}, {"family": "Emadi", "given": "Alireza", "initials": "A"}, {"family": "Eslami", "given": "Majid", "initials": "M"}], "type": "journal article", "published": "2021-10-23", "journal": {"title": "Med Gas Res", "issn": "2045-9912", "volume": "12", "issue": "2", "pages": "33-40", "issn-l": null}, "abstract": "Atmospheric ozone is produced when nitrogen oxides react with volatile organic compounds. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome contains a unique N-terminal fragment in the Spike protein, which allows it to bind to air pollutants in the environment. 'Our approach in this review is to study ozone and its effect on the SARS-CoV-2 virus and patients with coronavirus disease 2019 (COVID-19). Article data were collected from PubMed, Scopus, and Google Scholar databases. Ozone therapy has antiviral properties, improves blood flow, facilitates the transfer of oxygen in hypoxemic tissues, and reduces blood coagulation phenomena in COVID-19 patients. Ozone has immunomodulatory effects by modulating cytokines (reduction of interleukin-1, interleukin-6, tumor necrosis factor-\u03b1, and interleukin-10), induction of interferon-\u03b3, anti-inflammatory properties by modulating NOD-, LRR- and pyrin domain-containing protein 3, inhibition of cytokine storm (blocking nuclear factor-\u03baB and stimulating nuclear factor erythroid 2-related factor 2 pathway), stimulates cellular/humoral immunity/phagocytic function and blocks angiotensin-converting enzyme 2. In direct oxygen-ozone injection, oxygen reacts with several biological molecules such as thiol groups in albumin to form ozonoids. Intravenous injection of ozonated saline significantly increases the length of time a person can remain hypoxic. The rectal ozone protocol is rectal ozone insufflation, resulting in clinical improvement in oxygen saturation and biochemical improvement (fibrinogen, D-dimer, urea, ferritin, LDH, interleukin-6, and C-reactive protein). In general, many studies have shown the positive effect of ozone therapy as a complementary therapy in the recovery of COVID-19 patients. All the findings indicate that systemic ozone therapy is nontoxic and has no side effects in these patients.", "doi": "10.4103/2045-9912.325989", "pmid": "34677149", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "MedGasRes_2022_12_2_33_325989"}], "notes": [], "created": "2021-10-26T18:13:10.520Z", "modified": "2021-10-26T18:13:10.562Z"}, {"entity": "publication", "iuid": "309ad45ec547436298caa7a3df2df00d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/309ad45ec547436298caa7a3df2df00d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/309ad45ec547436298caa7a3df2df00d"}}, "title": "Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19.", "authors": [{"family": "Schulthei\u00df", "given": "Christoph", "initials": "C"}, {"family": "Paschold", "given": "Lisa", "initials": "L"}, {"family": "Willscher", "given": "Edith", "initials": "E"}, {"family": "Simnica", "given": "Donjete", "initials": "D"}, {"family": "W\u00f6stemeier", "given": "Anna", "initials": "A"}, {"family": "Muscate", "given": "Franziska", "initials": "F"}, {"family": "Wass", "given": "Maxi", "initials": "M"}, {"family": "Eisenmann", "given": "Stephan", "initials": "S"}, {"family": "Dutzmann", "given": "Jochen", "initials": "J"}, {"family": "Key\u00dfer", "given": "Gernot", "initials": "G"}, {"family": "Gagliani", "given": "Nicola", "initials": "N"}, {"family": "Binder", "given": "Mascha", "initials": "M"}], "type": "journal article", "published": "2021-10-23", "journal": {"title": "iScience", "issn": "2589-0042", "pages": "103325", "issn-l": "2589-0042"}, "abstract": "In parasite and viral infections, aberrant B cell responses can suppress germinal center reactions thereby blunting long-lived memory and may provoke immunopathology including autoimmunity. Using COVID-19 as model, we set out to identify serological, cellular and transcriptomic imprints of pathological responses linked to autoreactive B cells at single-cell resolution. We show that excessive plasmablast expansions are prognostically adverse, correlate with auto-antibody production, but do not hinder the formation of neutralizing antibodies. While plasmablasts followed IL-4 and BAFF driven developmental trajectories, were polyclonal and not enriched in autoreactive B cells, we identified two memory populations (CD80+/ISG15+ and CD11c+/SOX5+/T-bet+/-) with immunogenetic and transcriptional signs of autoreactivity that may be the cellular source of auto-antibodies in COVID-19 and that may persist beyond recovery. Immunomodulatory interventions discouraging such adverse responses may be useful in selected patients to shift the balance from autoreactivity towards long-term memory.", "doi": "10.1016/j.isci.2021.103325", "pmid": "34723157", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(21)01294-3"}, {"db": "pmc", "key": "PMC8536484"}], "notes": [], "created": "2021-11-02T15:32:21.332Z", "modified": "2021-11-02T15:32:55.847Z"}, {"entity": "publication", "iuid": "38187affa925475985a1875afa76de7b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38187affa925475985a1875afa76de7b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38187affa925475985a1875afa76de7b"}}, "title": "Family Function and Child Adjustment Difficulties in the COVID-19 Pandemic: An International Study.", "authors": [{"family": "Foley", "given": "Sarah", "initials": "S"}, {"family": "Badinlou", "given": "Farzaneh", "initials": "F"}, {"family": "Brocki", "given": "Karin C", "initials": "KC"}, {"family": "Frick", "given": "Matilda A", "initials": "MA"}, {"family": "Ronchi", "given": "Luca", "initials": "L", "orcid": "0000-0001-7723-9376", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1e89c62c76f443288c1df82f370cdf4.json"}}, {"family": "Hughes", "given": "Claire", "initials": "C"}], "type": "journal article", "published": "2021-10-23", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "21", "issn-l": null}, "abstract": "To estimate specific proximal and distal effects of COVID-19-related restrictions on families on children's adjustment problems, we conducted a six-site international study. In total, 2516 parents from Australia, China, Italy, Sweden, the United Kingdom, and the United States of America living with a young child (M = 5.77, ageSD = 1.10, range = 3 to 8 years, 47.9% female) completed an online survey between April and July 2020. The survey included the Strengths and Difficulties Questionnaire and family risk factors (parent distress, parent-child conflict, couple conflict, and household chaos) as well as a scale to index COVID-19-related family disruption. Our analyses also included public data on the stringency of national restrictions. Across the six sites, parental responses indicated elevated levels of hyperactivity, conduct, and emotion problems in children from families characterized by heightened levels of parent distress, parent-child conflict, and household chaos. In contrast, increased peer problems were more strongly related to COVID-19-related social disruption and stringency measures. Mediation models demonstrated that associations between COVID-19 social disruption and child difficulties could be explained by parental distress. Taken together, these results suggest that although the experience of the pandemic differed across countries, associations between COVID-19-related family experiences and child adjustment difficulties were similar in their nature and magnitude across six different contexts. Programs to support family resilience could help buffer the impact of the pandemic for two generations.", "doi": "10.3390/ijerph182111136", "pmid": "34769654", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph182111136"}, {"db": "pmc", "key": "PMC8582895"}], "notes": [], "created": "2021-11-26T15:10:11.167Z", "modified": "2021-11-26T15:10:11.226Z"}, {"entity": "publication", "iuid": "38d1fc5ab22a4d00aedc4f1700140bdf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38d1fc5ab22a4d00aedc4f1700140bdf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38d1fc5ab22a4d00aedc4f1700140bdf"}}, "title": "Use of Quantitative Dried Blood Spots to Evaluate the Post-Vaccination Level of Neutralizing Antibodies against SARS-CoV-2.", "authors": [{"family": "Marchand", "given": "Alexandre", "initials": "A", "orcid": "0000-0002-2670-6939", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19b0f52f01ef473d91392b151603c1c3.json"}}, {"family": "Roulland", "given": "Ingrid", "initials": "I"}, {"family": "Semence", "given": "Florian", "initials": "F", "orcid": "0000-0002-2313-9246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2fef84471334fb8b8688905d5426487.json"}}, {"family": "Beck", "given": "Olof", "initials": "O"}, {"family": "Ericsson", "given": "Magnus", "initials": "M", "orcid": "0000-0002-4123-3084", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72e1b083138945508edb8121d47826e3.json"}}], "type": "journal article", "published": "2021-10-22", "journal": {"title": "Life (Basel)", "issn": "2075-1729", "volume": "11", "issue": "11", "pages": "1125", "issn-l": null}, "abstract": "To combat the COVID-19 pandemic, vaccines against SARS-CoV-2 are now given to protect populations worldwide. The level of neutralizing antibodies following the vaccination will evolve with time and vary between individuals. Immunoassays quantifying immunoglobulins against the viral spike (S) protein in serum/plasma have been developed, but the need for venous blood samples could limit the frequency and scale of control in populations. The use of a quantitative dried blood spot (DBS) that can be self-collected would simplify this monitoring. The objective of this study was to determine whether a quantitative DBS device (Capitainer qDBS 10 \u00b5L) could be used in combination with an Elecsys anti-SARS-CoV-2 S immunoassay from Roche to follow the development and persistence of anti-S antibodies. This objective was carried out through two clinical studies. The first study investigated 14 volunteers who received two doses of the Comirnaty (Pfizer) vaccine. The levels of anti-S antibodies and the progression over time post-vaccination were studied for three months. The level of produced antibodies varied between subjects, but a similar trend was observed. The anti-S antibodies were highly stimulated by the second dose (\u00d7100) and peaked two weeks later. The antibody levels subsequently decreased and three months later were down to 65%. DBS proved to be sufficiently sensitive for use in evaluating the immune status against SARS-CoV-2 over a prolonged time. The second cohort was composed of 200 random patients from a clinical chemistry department in Stockholm. In this cohort, we had no information on previous COVID-19 infections or vaccination. Nevertheless, 87% of the subjects had anti-S immunoglobulins over 0.8 U/mL, and the bias between plasma and DBS proved to be variable, as was also seen in the first vaccination study.", "doi": "10.3390/life11111125", "pmid": "34833001", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8620034"}, {"db": "pii", "key": "life11111125"}], "notes": [], "created": "2021-12-18T18:15:01.656Z", "modified": "2023-06-19T14:20:04.060Z"}, {"entity": "publication", "iuid": "82b7b8a2c81044dd954af8d86a918c8d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82b7b8a2c81044dd954af8d86a918c8d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82b7b8a2c81044dd954af8d86a918c8d"}}, "title": "SARS-CoV-2 specific B- and T-cell immunity in a population-based study of young Swedish adults.", "authors": [{"family": "Bj\u00f6rkander", "given": "Sophia", "initials": "S"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Zuo", "given": "Fanglei", "initials": "F"}, {"family": "Ekstr\u00f6m", "given": "Sandra", "initials": "S"}, {"family": "Wang", "given": "Yating", "initials": "Y"}, {"family": "Wan", "given": "Hui", "initials": "H"}, {"family": "Sherina", "given": "Natalia", "initials": "N"}, {"family": "Schoutens", "given": "Lisanne", "initials": "L"}, {"family": "Andr\u00e9ll", "given": "Juni", "initials": "J"}, {"family": "Andersson", "given": "Niklas", "initials": "N"}, {"family": "Georgelis", "given": "Antonios", "initials": "A"}, {"family": "Bergstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}, {"family": "BAMSE COVID-19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-10-22", "journal": {"title": "J Allergy Clin Immunol", "issn": "1097-6825", "issn-l": "0091-6749"}, "abstract": "Young adults are now considered major spreaders of COVID-19 disease. Although most young individuals suffer from mild to moderate disease, there are concerns of long-term adverse health effects. The impact of COVID-19 disease and to which extent population-level immunity against SARS-CoV-2 exist in young adults remain unclear.\n\nTo conduct a population-based study on humoral and cellular immunity to SARS-CoV-2 and explore COVID-19 disease characteristics in young adults.\n\nWe invited participants from the Swedish BAMSE birth cohort (age 24-27 years) to take part in a COVID-19 follow-up. From 980 participants (October 2020-June 2021), we here present data on SARS-CoV-2 RBD-specific IgM, IgA and IgG titres measured by ELISA and on symptoms and epidemiological factors associated with seropositivity. Further, SARS-CoV-2-specific memory B- and T-cell responses were detected for a subpopulation (n=108) by ELISpot and Fluorospot.\n\n28.4% of subjects were seropositive of which 18.4% were IgM single positive. One in seven seropositive subjects were asymptomatic. Seropositivity associated with use of public transport, but not with sex, asthma, rhinitis, IgE-sensitization, smoking or BMI. In a subset of representative samples, 20.7% and 35.0% had detectable SARS-CoV-2 specific B- and T-cell responses, respectively. B- and T-cell memory responses were clearly associated with seropositivity, but T-cell responses were also detected in 17.2% of seronegative subjects.\n\nAssessment of IgM and T-cell responses may improve population-based estimations of SARS-CoV-2 infection. The pronounced surge of both symptomatic and asymptomatic infections among young adults should imply a continuation of the large-scale vaccination campaign.", "doi": "10.1016/j.jaci.2021.10.014", "pmid": "34695490", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Funder: VR": null, "Funder: H2020": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pii", "key": "S0091-6749(21)01626-2"}], "notes": [], "created": "2021-10-26T18:21:08.827Z", "modified": "2021-10-26T18:23:13.339Z"}, {"entity": "publication", "iuid": "c5eee811036f4f19b853bdb01f8ecbbc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5eee811036f4f19b853bdb01f8ecbbc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5eee811036f4f19b853bdb01f8ecbbc"}}, "title": "Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue.", "authors": [{"family": "Niessl", "given": "Julia", "initials": "J", "orcid": "0000-0001-8852-1924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70aba42c7f0b400eba1a226ee193d9fd.json"}}, {"family": "Sekine", "given": "Takuya", "initials": "T", "orcid": "0000-0001-7649-0593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a234e0d77c145aa8d23b89fde1c5883.json"}}, {"family": "Lange", "given": "Joshua", "initials": "J", "orcid": "0000-0001-6452-0695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1cca3794b2844599b618aa215421d61b.json"}}, {"family": "Konya", "given": "Viktoria", "initials": "V"}, {"family": "Forkel", "given": "Marianne", "initials": "M"}, {"family": "Maric", "given": "Jovana", "initials": "J"}, {"family": "Rao", "given": "Anna", "initials": "A"}, {"family": "Mazzurana", "given": "Luca", "initials": "L"}, {"family": "Kokkinou", "given": "Efthymia", "initials": "E"}, {"family": "Weigel", "given": "Whitney", "initials": "W"}, {"family": "Llewellyn-Lacey", "given": "Sian", "initials": "S", "orcid": "0000-0002-4703-0413", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d3831e832f6b490d9b24d89170e66eaa.json"}}, {"family": "Hodcroft", "given": "Emma B", "initials": "EB", "orcid": "0000-0002-0078-2212", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/563993c9fb68466c8867ca7600733548.json"}}, {"family": "Karlsson", "given": "Annika C", "initials": "AC", "orcid": "0000-0002-2028-8393", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9abf28110888427497db1e4abf6ff71d.json"}}, {"family": "Fehrm", "given": "Johan", "initials": "J", "orcid": "0000-0002-4304-3700", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/948413806ff24d02b4f0016c8e1af6bf.json"}}, {"family": "Sundman", "given": "Joar", "initials": "J", "orcid": "0000-0003-4475-603X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5092a6807ecd460d83fd07790267fac6.json"}}, {"family": "Price", "given": "David A", "initials": "DA", "orcid": "0000-0001-9416-2737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/734b7fd55fca47f8b00d1281331ef39a.json"}}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J", "orcid": "0000-0002-1119-0976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41c258d321084e909f0c9a6ff8693533.json"}}, {"family": "Friberg", "given": "Danielle", "initials": "D", "orcid": "0000-0001-8327-1292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7003e0514ab84574b19ac36dff3f8825.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}], "type": "journal article", "published": "2021-10-22", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "issn-l": "2470-9468", "volume": "6", "issue": "64", "pages": "eabk0894"}, "abstract": "Cross-reactive CD4+ T cells that recognize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more commonly detected in the peripheral blood of unexposed individuals compared with SARS-CoV-2\u2013reactive CD8+ T cells. However, large numbers of memory CD8+ T cells reside in tissues, feasibly harboring localized SARS-CoV-2\u2013specific immune responses. To test this idea, we performed a comprehensive functional and phenotypic analysis of virus-specific T cells in tonsils, a major lymphoid tissue site in the upper respiratory tract, and matched peripheral blood samples obtained from children and adults before the emergence of COVID-19 (coronavirus disease 2019). We found that SARS-CoV-2\u2013specific memory CD4+ T cells could be found at similar frequencies in the tonsils and peripheral blood in unexposed individuals, whereas functional SARS-CoV-2\u2013specific memory CD8+ T cells were almost only detectable in the tonsils. Tonsillar SARS-CoV-2\u2013specific memory CD8+ T cells displayed a follicular homing and tissue-resident memory phenotype, similar to tonsillar Epstein-Barr virus\u2013specific memory CD8+ T cells, but were functionally less potent than other virus-specific memory CD8+ T cell responses. The presence of preexisting tissue-resident memory CD8+ T cells in unexposed individuals could potentially enable rapid sentinel immune responses against SARS-CoV-2.", "doi": "10.1126/sciimmunol.abk0894", "pmid": "34519539", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: VR": null}, "xrefs": [], "notes": [], "created": "2021-09-20T06:25:17.561Z", "modified": "2023-06-19T14:47:48.944Z"}, {"entity": "publication", "iuid": "691b17ed7dd44d05923a3ddeca351561", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/691b17ed7dd44d05923a3ddeca351561.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/691b17ed7dd44d05923a3ddeca351561"}}, "title": "Epidemic versus economic performances of the COVID-19 lockdown in Japan: A Mobility Data Analysis.", "authors": [{"family": "Zhang", "given": "Haoran", "initials": "H"}, {"family": "Li", "given": "Peiran", "initials": "P"}, {"family": "Zhang", "given": "Zhiwen", "initials": "Z"}, {"family": "Li", "given": "Wenjing", "initials": "W"}, {"family": "Chen", "given": "Jinyu", "initials": "J"}, {"family": "Song", "given": "Xuan", "initials": "X"}, {"family": "Shibasaki", "given": "Ryosuke", "initials": "R"}, {"family": "Yan", "given": "Jinyue", "initials": "J"}], "type": "journal article", "published": "2021-10-22", "journal": {"title": "Cities", "issn": "0264-2751", "issn-l": null, "volume": null, "issue": null, "pages": "103502"}, "abstract": "Lockdown measures have been a \"panacea\" for pandemic control but also a violent \"poison\" for economies. Lockdown policies strongly restrict human mobility but mobility reduce does harm to economics. Governments meet a thorny problem in balancing the pros and cons of lockdown policies, but lack comprehensive and quantified guides. Based on millions of financial transaction records, and billions of mobility data, we tracked spatio-temporal business networks and human daily mobility, then proposed a high-resolution two-sided framework to assess the epidemiological performance and economic damage of different lockdown policies. We found that the pandemic duration under the strictest lockdown is less about two months than that under the lightest lockdown, which makes the strictest lockdown characterize both epidemiologically and economically efficient. Moreover, based on the two-sided model, we explored the spatial lockdown strategy. We argue that cutting off intercity commuting is significant in both epidemiological and economical aspects, and finally helped governments figure out the Pareto optimal solution set of lockdown strategy.", "doi": "10.1016/j.cities.2021.103502", "pmid": "34703071", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0264-2751(21)00401-7"}, {"db": "pmc", "key": "PMC8531026"}], "notes": [], "created": "2021-11-01T19:41:11.603Z", "modified": "2021-11-01T19:41:41.272Z"}, {"entity": "publication", "iuid": "dacbc120d6864970a1e0bad1a9fb510e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dacbc120d6864970a1e0bad1a9fb510e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dacbc120d6864970a1e0bad1a9fb510e"}}, "title": "Clozapine treatment and risk of severe COVID-19 infection.", "authors": [{"family": "Ohlis", "given": "Anna", "initials": "A", "orcid": "0000-0001-9046-5773", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59faf1045fa242d28c4044315d0181d2.json"}}, {"family": "S\u00f6rberg Wallin", "given": "Alma", "initials": "A", "orcid": "0000-0002-8804-095X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bdaa3ba8e9c149a6b4c05d924f31d0e5.json"}}, {"family": "Sarafis", "given": "Anna", "initials": "A"}, {"family": "Sj\u00f6qvist", "given": "Hugo", "initials": "H"}, {"family": "MacCabe", "given": "James H", "initials": "JH", "orcid": "0000-0002-6754-1018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10525437e48b4917bcea4011f1db2d66.json"}}, {"family": "Ahlen", "given": "Johan", "initials": "J", "orcid": "0000-0003-1415-2200", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0bb3ddc3a2e0432585cf06c038554088.json"}}, {"family": "Dalman", "given": "Christina", "initials": "C"}], "type": "journal article", "published": "2021-10-22", "journal": {"title": "Acta Psychiatr Scand", "issn": "1600-0447", "issn-l": null}, "abstract": "To investigate whether patients with clozapine treatment are at an increased risk of a more severe COVID-19 infection as compared with patients on other antipsychotic drugs.\n\nIn this register-based cohort study, all residents (age 18 or older) in the Stockholm Region with a psychotic disorder diagnosis and antipsychotic treatment were included (N = 8 233) and followed from March 1, 2020 to January 14, 2021. The exposure was defined as clozapine treatment and the outcome measures (indicating a more severe COVID-19 infection) were: inpatient care, care within intensive care unit or death due to COVID-19 infection. Differences in outcome rates between exposed (n = 966) and unexposed (other antipsychotics; n = 7 267) were examined using Cox proportional hazards models and expressed as hazard ratios (HR) with 95% confidence intervals (CI).\n\nNo statistically significant differences in outcome rates were found between the two groups of patients after adjusting for age, sex, and residence in retirement homes. The adjusted HR for the exposed compared to the unexposed was 0.96 (95% CI: 0.54, 1.70) for inpatient care; 1.69 (0.48, 5.93) for care in intensive care unit (ICU); and 0.86 (0.26, 2.80) for death. Regarding inpatient care, additional adjusting for country of birth, living in socioeconomically vulnerable areas, number of care visits during the previous year, and comorbid medical illnesses did not alter the results.\n\nOur results may add support to the present guidelines, recommending sustained clozapine treatment during the current COVID-19 pandemic with careful monitoring and readiness to alter drug doses as needed.", "doi": "10.1111/acps.13379", "pmid": "34676888", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:12:37.225Z", "modified": "2021-10-26T18:12:50.320Z"}, {"entity": "publication", "iuid": "c298ed13cf994b5d98401e37cd050838", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c298ed13cf994b5d98401e37cd050838.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c298ed13cf994b5d98401e37cd050838"}}, "title": "Recurrent sick leave after COVID-19: investigating the first wave of the pandemic in a comprehensive Swedish registry-based study.", "authors": [{"family": "Palstam", "given": "Annie", "initials": "A"}, {"family": "Westerlind", "given": "Emma", "initials": "E"}, {"family": "Sunnerhagen", "given": "Katharina S", "initials": "KS"}, {"family": "Persson", "given": "Hanna C", "initials": "HC"}], "type": "journal article", "published": "2021-10-21", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "1914"}, "abstract": "Sick-leave due to COVID-19 vary in length and might lead to re-current episodes. The aim was to investigate recurrent sick leave due to COVID-19 during the first wave.\r\n\r\nThis is a registry-based cohort study. The study comprises all people with sickness benefit due to COVID-19 in Sweden in March 1-August 31, 2020. Data from the Swedish Social Insurance Agency, the Swedish National Board of Health and Welfare, and Statistics Sweden were merged.\r\n\r\nWithin the follow-up period of 4 months, 11,955 people were subject to sickness benefit due to COVID-19, whereof 242 people (2.0%) took recurrent sick leave due to COVID-19, and of those 136 (56.2%) remained on sick leave at the end of follow-up. People with recurrent sick leave were older, more often women, and more likely to have been on sick leave prior to the COVID-19 pandemic.\r\n\r\nA group of people presented with recurrent sick leave due to COVID-19. For half of them, the second sick leave lasted throughout the follow-up. People with recurrent sick leave differ in several aspects from those with shorter sick leave. To capture long-term sick-leave patterns due to COVID-19, a longer period of follow-up is needed.", "doi": "10.1186/s12889-021-11918-y", "pmid": "34674673", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11918-y"}], "notes": [], "created": "2021-10-26T18:11:12.252Z", "modified": "2022-02-17T12:20:09.405Z"}, {"entity": "publication", "iuid": "258c795b973e4ab0a2adf939ddf7850b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/258c795b973e4ab0a2adf939ddf7850b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/258c795b973e4ab0a2adf939ddf7850b"}}, "title": "Implementation Science for Managers and Healthcare Organizations Responding to Emergencies", "authors": [{"family": "\u00d8vretveit", "given": "John", "initials": "J", "orcid": "0000-0001-9668-0175", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82d14033e7314a27a9ac093d99058bc8.json"}}, {"family": "Ohrling", "given": "Mikael", "initials": "M"}], "type": "journal-article", "published": "2021-10-21", "journal": {"title": "Glob Implement Res Appl", "issn": "2662-9275", "issn-l": null}, "abstract": null, "doi": "10.1007/s43477-021-00025-0", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:34:02.123Z", "modified": "2021-10-26T18:34:02.202Z"}, {"entity": "publication", "iuid": "6e938e1c59d2428bb1f45af94644ba6c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e938e1c59d2428bb1f45af94644ba6c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e938e1c59d2428bb1f45af94644ba6c"}}, "title": "Immunogenicity and safety of AZD1222 (ChAdOx1 nCoV-19) against SARS-CoV-2 in Japan: A double-blind, randomized controlled phase 1/2 trial.", "authors": [{"family": "Asano", "given": "Michiko", "initials": "M"}, {"family": "Okada", "given": "Hiroshi", "initials": "H"}, {"family": "Itoh", "given": "Yohji", "initials": "Y"}, {"family": "Hirata", "given": "Hajime", "initials": "H"}, {"family": "Ishikawa", "given": "Kensuke", "initials": "K"}, {"family": "Yoshida", "given": "Erika", "initials": "E"}, {"family": "Matsui", "given": "Akiko", "initials": "A"}, {"family": "Kelly", "given": "Elizabeth J", "initials": "EJ"}, {"family": "Shoemaker", "given": "Kathryn", "initials": "K"}, {"family": "Olsson", "given": "Urban", "initials": "U"}, {"family": "Vekemans", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2021-10-21", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712"}, "abstract": "Immunogenicity and safety of the AZD1222 (ChAdOx1 nCoV-19) vaccine was evaluated in Japanese adults in an ongoing phase 1/2, randomized, double-blind, parallel-group, placebo-controlled, multicenter trial (NCT04568031).\n\nAdults (N=256; age \u226518 years) seronegative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were stratified by age into 18-55- (n=128), 56-69- (n=86), and \u226570-year-old cohorts (n=42), then randomized 3:1 to receive AZD1222 or placebo (2 intramuscular injections 4 weeks apart). Immunogenicity and safety were coprimary endpoints. Data collected up to Day 57 are reported.\n\nPositive seroresponses to SARS-CoV-2 spike and receptor-binding domain antigens were seen in all 174 participants who received 2 doses of AZD1222. Neutralizing antibody seroresponses were seen in 67.5%, 60.3%, and 50.0% of participants receiving AZD1222 aged 18-55, 56-69, and \u226570 years, respectively. Solicited adverse events (AEs) were typically mild/moderate in severity and included injection site pain and tenderness, malaise, fatigue, muscle pains, and headache. Common unsolicited AEs included injection site pain and tenderness, fatigue, and elevated body temperature. No vaccine-related serious AEs or deaths were reported.\n\nAZD1222 elicited a strong humoral immune response against SARS-CoV-2 and was well tolerated in Japanese participants, including elderly participants.", "doi": "10.1016/j.ijid.2021.10.030", "pmid": "34688944", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)00818-3"}, {"db": "ClinicalTrials.gov", "key": "NCT04568031"}], "notes": [], "created": "2021-10-26T18:19:19.803Z", "modified": "2021-10-26T18:19:19.816Z"}, {"entity": "publication", "iuid": "09e3fbede2484edabd3786ae8bd64fd5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/09e3fbede2484edabd3786ae8bd64fd5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/09e3fbede2484edabd3786ae8bd64fd5"}}, "title": "Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia: The COVID STEROID 2 Randomized Trial.", "authors": [{"family": "COVID STEROID 2 Trial Group", "given": "", "initials": ""}, {"family": "Munch", "given": "Marie W", "initials": "MW"}, {"family": "Myatra", "given": "Sheila N", "initials": "SN"}, {"family": "Vijayaraghavan", "given": "Bharath Kumar Tirupakuzhi", "initials": "BKT"}, {"family": "Saseedharan", "given": "Sanjith", "initials": "S"}, {"family": "Benfield", "given": "Thomas", "initials": "T"}, {"family": "Wahlin", "given": "Rebecka R", "initials": "RR"}, {"family": "Rasmussen", "given": "Bodil S", "initials": "BS"}, {"family": "Andreasen", "given": "Anne Sofie", "initials": "AS"}, {"family": "Poulsen", "given": "Lone M", "initials": "LM"}, {"family": "Cioccari", "given": "Luca", "initials": "L"}, {"family": "Khan", "given": "Mohd S", "initials": "MS"}, {"family": "Kapadia", "given": "Farhad", "initials": "F"}, {"family": "Divatia", "given": "Jigeeshu V", "initials": "JV"}, {"family": "Br\u00f8chner", "given": "Anne C", "initials": "AC"}, {"family": "Bestle", "given": "Morten H", "initials": "MH"}, {"family": "Helleberg", "given": "Marie", "initials": "M"}, {"family": "Michelsen", "given": "Jens", "initials": "J"}, {"family": "Padmanaban", "given": "Ajay", "initials": "A"}, {"family": "Bose", "given": "Neeta", "initials": "N"}, {"family": "M\u00f8ller", "given": "Anders", "initials": "A"}, {"family": "Borawake", "given": "Kapil", "initials": "K"}, {"family": "Kristiansen", "given": "Klaus T", "initials": "KT"}, {"family": "Shukla", "given": "Urvi", "initials": "U"}, {"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Dixit", "given": "Subhal", "initials": "S"}, {"family": "Ulrik", "given": "Charlotte S", "initials": "CS"}, {"family": "Amin", "given": "Pravin R", "initials": "PR"}, {"family": "Chawla", "given": "Rajesh", "initials": "R"}, {"family": "Wamberg", "given": "Christian A", "initials": "CA"}, {"family": "Shah", "given": "Mehul S", "initials": "MS"}, {"family": "Darfelt", "given": "Iben S", "initials": "IS"}, {"family": "J\u00f8rgensen", "given": "Vibeke L", "initials": "VL"}, {"family": "Smitt", "given": "Margit", "initials": "M"}, {"family": "Granholm", "given": "Anders", "initials": "A"}, {"family": "Kj\u00e6r", "given": "Maj-Brit N", "initials": "MN"}, {"family": "M\u00f8ller", "given": "Morten H", "initials": "MH"}, {"family": "Meyhoff", "given": "Tine S", "initials": "TS"}, {"family": "Vesterlund", "given": "Gitte K", "initials": "GK"}, {"family": "Hammond", "given": "Naomi E", "initials": "NE"}, {"family": "Micallef", "given": "Sharon", "initials": "S"}, {"family": "Bassi", "given": "Abhinav", "initials": "A"}, {"family": "John", "given": "Oommen", "initials": "O"}, {"family": "Jha", "given": "Anubhuti", "initials": "A"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Jakob", "given": "Stephan M", "initials": "SM"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Lange", "given": "Theis", "initials": "T"}, {"family": "Kadam", "given": "Vaijayanti", "initials": "V"}, {"family": "Marcussen", "given": "Klaus V", "initials": "KV"}, {"family": "Hollenberg", "given": "Jacob", "initials": "J"}, {"family": "Hedman", "given": "Anders", "initials": "A"}, {"family": "Nielsen", "given": "Henrik", "initials": "H"}, {"family": "Schj\u00f8rring", "given": "Olav L", "initials": "OL"}, {"family": "Jensen", "given": "Marie Q", "initials": "MQ"}, {"family": "Leistner", "given": "Jens W", "initials": "JW"}, {"family": "Jonassen", "given": "Trine B", "initials": "TB"}, {"family": "Kristensen", "given": "Camilla M", "initials": "CM"}, {"family": "Clapp", "given": "Esben C", "initials": "EC"}, {"family": "Hjorts\u00f8", "given": "Carl J S", "initials": "CJS"}, {"family": "Jensen", "given": "Thomas S", "initials": "TS"}, {"family": "Halstad", "given": "Liv S", "initials": "LS"}, {"family": "Bak", "given": "Emilie R B", "initials": "ERB"}, {"family": "Zaabalawi", "given": "Reem", "initials": "R"}, {"family": "Metcalf-Clausen", "given": "Matias", "initials": "M"}, {"family": "Abdi", "given": "Suhayb", "initials": "S"}, {"family": "Hatley", "given": "Emma V", "initials": "EV"}, {"family": "Aksnes", "given": "Tobias S", "initials": "TS"}, {"family": "Gleipner-Andersen", "given": "Emil", "initials": "E"}, {"family": "Alarc\u00f3n", "given": "Arif F", "initials": "AF"}, {"family": "Yamin", "given": "Gabriel", "initials": "G"}, {"family": "Heymowski", "given": "Adam", "initials": "A"}, {"family": "Berggren", "given": "Anton", "initials": "A"}, {"family": "La Cour", "given": "Kirstine", "initials": "K"}, {"family": "Weihe", "given": "Sarah", "initials": "S"}, {"family": "Pind", "given": "Alison H", "initials": "AH"}, {"family": "Engstr\u00f8m", "given": "Janus", "initials": "J"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Venkatesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Perner", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-10-21", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484"}, "abstract": "A daily dose with 6 mg of dexamethasone is recommended for up to 10 days in patients with severe and critical COVID-19, but a higher dose may benefit those with more severe disease.\n\nTo assess the effects of 12 mg/d vs 6 mg/d of dexamethasone in patients with COVID-19 and severe hypoxemia.\n\nA multicenter, randomized clinical trial was conducted between August 2020 and May 2021 at 26 hospitals in Europe and India and included 1000 adults with confirmed COVID-19 requiring at least 10 L/min of oxygen or mechanical ventilation. End of 90-day follow-up was on August 19, 2021.\n\nPatients were randomized 1:1 to 12 mg/d of intravenous dexamethasone (n = 503) or 6 mg/d of intravenous dexamethasone (n = 497) for up to 10 days.\n\nThe primary outcome was the number of days alive without life support (invasive mechanical ventilation, circulatory support, or kidney replacement therapy) at 28 days and was adjusted for stratification variables. Of the 8 prespecified secondary outcomes, 5 are included in this analysis (the number of days alive without life support at 90 days, the number of days alive out of the hospital at 90 days, mortality at 28 days and at 90 days, and \u22651 serious adverse reactions at 28 days).\n\nOf the 1000 randomized patients, 982 were included (median age, 65 [IQR, 55-73] years; 305 [31%] women) and primary outcome data were available for 971 (491 in the 12 mg of dexamethasone group and 480 in the 6 mg of dexamethasone group). The median number of days alive without life support was 22.0 days (IQR, 6.0-28.0 days) in the 12 mg of dexamethasone group and 20.5 days (IQR, 4.0-28.0 days) in the 6 mg of dexamethasone group (adjusted mean difference, 1.3 days [95% CI, 0-2.6 days]; P = .07). Mortality at 28 days was 27.1% in the 12 mg of dexamethasone group vs 32.3% in the 6 mg of dexamethasone group (adjusted relative risk, 0.86 [99% CI, 0.68-1.08]). Mortality at 90 days was 32.0% in the 12 mg of dexamethasone group vs 37.7% in the 6 mg of dexamethasone group (adjusted relative risk, 0.87 [99% CI, 0.70-1.07]). Serious adverse reactions, including septic shock and invasive fungal infections, occurred in 11.3% in the 12 mg of dexamethasone group vs 13.4% in the 6 mg of dexamethasone group (adjusted relative risk, 0.83 [99% CI, 0.54-1.29]).\n\nAmong patients with COVID-19 and severe hypoxemia, 12 mg/d of dexamethasone compared with 6 mg/d of dexamethasone did not result in statistically significantly more days alive without life support at 28 days. However, the trial may have been underpowered to identify a significant difference.\n\nClinicalTrials.gov Identifier: NCT04509973 and ctri.nic.in Identifier: CTRI/2020/10/028731.", "doi": "10.1001/jama.2021.18295", "pmid": "34673895", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "2785529"}, {"db": "ClinicalTrials.gov", "key": "NCT04509973"}], "notes": [], "created": "2021-10-26T18:09:59.402Z", "modified": "2021-10-26T18:10:15.618Z"}, {"entity": "publication", "iuid": "b708ee46f2fc46ba9e5b696c9ee88580", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b708ee46f2fc46ba9e5b696c9ee88580.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b708ee46f2fc46ba9e5b696c9ee88580"}}, "title": "Distress Levels of Parents of Children with Neurodevelopmental Disorders during the COVID-19 Pandemic: A Comparison between Italy and Australia.", "authors": [{"family": "Burnett", "given": "Dayle", "initials": "D", "orcid": "0000-0003-0943-7973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33de85e857374d3b813fa2a886b489f7.json"}}, {"family": "Masi", "given": "Anne", "initials": "A"}, {"family": "Mendoza Diaz", "given": "Antonio", "initials": "A"}, {"family": "Rizzo", "given": "Renata", "initials": "R"}, {"family": "Lin", "given": "Ping-I", "initials": "PI", "orcid": "0000-0002-9739-7184", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/359146aaef914f14873beee4b6b43bcf.json"}}, {"family": "Eapen", "given": "Valsamma", "initials": "V", "orcid": "0000-0001-6296-8306", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e5564f68ee14bc4ba80b06b06997f90.json"}}], "type": "journal article", "published": "2021-10-21", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "21", "issn-l": null}, "abstract": "Parents of children with a neurodevelopmental disorder (NDD) report higher levels of distress compared to those of typically developing children. Distress levels may be heightened by the restrictions associated with the COVID-19 pandemic. However, it is unclear whether distress levels of parents varied by the diagnosis of neurodevelopmental disorder in children during the COVID-19 pandemic. This study aims to investigate whether parental distress was influenced by the type of NDD. Participants were from Australia (N = 196) and Italy (N = 200); the parents of children aged 3-18 were invited to complete an online self-reported survey which included the 6-item Kessler Psychological Distress Scale (K6) to determine parental distress. The results show that intellectual or learning disorder (ILD) is a major contributor to parental distress compared to other NDDs in both Australia and Italy. Moreover, the worsening of symptomatic changes in children with NDDs was significantly associated with parental distress. The differences between the two countries in terms of the pandemic impact, however, were not statistically significant. The results suggest that intervention strategies need to be tailored for individual clinical information and factor in the society's stringency level of anti-contagion policies to improve parental wellbeing.", "doi": "10.3390/ijerph182111066", "pmid": "34769585", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182111066"}, {"db": "pmc", "key": "PMC8583226"}, {"db": "figshare", "key": "10.6084/m9. figshare.16528998"}], "notes": [], "created": "2021-11-26T15:10:38.936Z", "modified": "2021-11-26T15:10:48.513Z"}, {"entity": "publication", "iuid": "04f67edcbc33433ab52163c3ab8b2591", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/04f67edcbc33433ab52163c3ab8b2591.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/04f67edcbc33433ab52163c3ab8b2591"}}, "title": "Advances and Utility of the Human Plasma Proteome", "authors": [{"family": "Deutsch", "given": "Eric W", "initials": "EW", "orcid": "0000-0001-8732-0928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a79e829ef590450696ffa9be36818a15.json"}}, {"family": "Omenn", "given": "Gilbert S", "initials": "GS", "orcid": "0000-0002-8976-6074", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be6adfe65b8345da8799a7d6af35c38d.json"}}, {"family": "Sun", "given": "Zhi", "initials": "Z", "orcid": "0000-0003-3324-6851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bc55a74b03b412b86616badb068af08.json"}}, {"family": "Maes", "given": "Michal", "initials": "M", "orcid": "0000-0002-7406-3982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cff13791bbc0457a89657357e2f6febf.json"}}, {"family": "Pernemalm", "given": "Maria", "initials": "M", "orcid": "0000-0003-4624-031X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6801d3242ee544a59d77ccd7256a4a30.json"}}, {"family": "Palaniappan", "given": "Krishnan K", "initials": "KK", "orcid": "0000-0003-0203-9016", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0de4251e52634dfda3157543df4187c5.json"}}, {"family": "Letunica", "given": "Natasha", "initials": "N", "orcid": "0000-0003-3604-1536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40ecd7338e3245c3a25614938b63ecf1.json"}}, {"family": "Vandenbrouck", "given": "Yves", "initials": "Y", "orcid": "0000-0002-1292-373X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12d928faa9d642eda7c27008bf2a85a6.json"}}, {"family": "Brun", "given": "Virginie", "initials": "V", "orcid": "0000-0002-9098-8707", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff2f9882dc0c447fa7dfdfd812aeac75.json"}}, {"family": "Tao", "given": "Sheng ce", "initials": "Sc", "orcid": "0000-0002-9210-1823", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e5c94e5298840c38b9aabcdd91599ac.json"}}, {"family": "Yu", "given": "Xiaobo", "initials": "X"}, {"family": "Geyer", "given": "Philipp E", "initials": "PE", "orcid": "0000-0001-7980-4826", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cec492eb8b214af1b35c081249a43ef2.json"}}, {"family": "Ignjatovic", "given": "Vera", "initials": "V", "orcid": "0000-0002-5548-5813", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b94d0fd7f56d491785df601cb8851722.json"}}, {"family": "Moritz", "given": "Robert L", "initials": "RL", "orcid": "0000-0002-3216-9447", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2aa533b8b0cb46689bf9862952bbc417.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67a59fa5de37434c8b7151039c192a37.json"}}], "type": "journal-article", "published": "2021-10-21", "journal": {"title": "J. Proteome Res.", "issn": "1535-3893", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The study of proteins circulating in blood offers tremendous opportunities to diagnose, stratify, or possibly prevent diseases. With recent technological advances and the urgent need to understand the effects of COVID-19, the proteomic analysis of blood-derived serum and plasma has become even more important for studying human biology and pathophysiology. Here we provide views and perspectives about technological developments and possible clinical applications that use mass-spectrometry(MS)- or affinity-based methods. We discuss examples where plasma proteomics contributed valuable insights into SARS-CoV-2 infections, aging, and hemostasis and the opportunities offered by combining proteomics with genetic data. As a contribution to the Human Proteome Organization (HUPO) Human Plasma Proteome Project (HPPP), we present the Human Plasma PeptideAtlas build 2021-07 that comprises 4395 canonical and 1482 additional nonredundant human proteins detected in 240 MS-based experiments. In addition, we report the new Human Extracellular Vesicle PeptideAtlas 2021-06, which comprises five studies and 2757 canonical proteins detected in extracellular vesicles circulating in blood, of which 74% (2047) are in common with the plasma PeptideAtlas. Our overview summarizes the recent advances, impactful applications, and ongoing challenges for translating plasma proteomics into utility for precision medicine.", "doi": "10.1021/acs.jproteome.1c00657", "pmid": "34672606", "labels": {"Category: Biochemistry": null, "Type: Review": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.1021/acs.jproteome.1c00657.s002", "description": "Union of proteins in both the plasma and blood extracellular vesicle PeptideAtlas builds, along with the crudely estimated log10 abundances and functional annotations"}], "notes": [], "created": "2021-10-26T14:47:22.298Z", "modified": "2021-11-19T10:45:18.691Z"}, {"entity": "publication", "iuid": "0868bd77cf724196bd1351491fb6f27e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0868bd77cf724196bd1351491fb6f27e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0868bd77cf724196bd1351491fb6f27e"}}, "title": "Acute and post-acute neurological manifestations of COVID-19: present findings, critical appraisal, and future directions.", "authors": [{"family": "Beghi", "given": "Ettore", "initials": "E", "orcid": "0000-0003-2542-0469", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08608536dadb4c84af6f3ea9c0a9f7e4.json"}}, {"family": "Giussani", "given": "Giorgia", "initials": "G"}, {"family": "Westenberg", "given": "Erica", "initials": "E"}, {"family": "Allegri", "given": "Ricardo", "initials": "R"}, {"family": "Garcia-Azorin", "given": "David", "initials": "D"}, {"family": "Guekht", "given": "Alla", "initials": "A"}, {"family": "Frontera", "given": "Jennifer", "initials": "J"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Mangialasche", "given": "Francesca", "initials": "F"}, {"family": "Mukaetova-Ladinska", "given": "Elizabeta B", "initials": "EB"}, {"family": "Prasad", "given": "Kameshwar", "initials": "K"}, {"family": "Chowdhary", "given": "Neerja", "initials": "N"}, {"family": "Winkler", "given": "Andrea Sylvia", "initials": "AS"}], "type": "journal article", "published": "2021-10-21", "journal": {"title": "J Neurol", "issn": "1432-1459", "issn-l": null}, "abstract": "Acute and post-acute neurological symptoms, signs and diagnoses have been documented in an increasing number of patients infected by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which causes Coronavirus Disease 2019 (COVID-19). In this review, we aimed to summarize the current literature addressing neurological events following SARS-CoV-2 infection, discuss limitations in the existing literature and suggest future directions that would strengthen our understanding of the neurological sequelae of COVID-19. The presence of neurological manifestations (symptoms, signs or diagnoses) both at the onset or during SARS-CoV-2 infection is associated with a more severe disease, as demonstrated by a longer hospital stay, higher in-hospital death rate or the continued presence of sequelae at discharge. Although biological mechanisms have been postulated for these findings, evidence-based data are still lacking to clearly define the incidence, range of characteristics and outcomes of these manifestations, particularly in non-hospitalized patients. In addition, data from low- and middle-income countries are scarce, leading to uncertainties in the measure of neurological findings of COVID-19, with reference to geography, ethnicity, socio-cultural settings, and health care arrangements. As a consequence, at present a specific phenotype that would specify a post-COVID (or long-COVID) neurological syndrome has not yet been identified.", "doi": "10.1007/s00415-021-10848-4", "pmid": "34674005", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00415-021-10848-4"}], "notes": [], "created": "2021-10-26T18:10:35.291Z", "modified": "2021-10-26T18:10:47.822Z"}, {"entity": "publication", "iuid": "ede3ddee591a4d2492385a9f0b07bf27", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ede3ddee591a4d2492385a9f0b07bf27.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ede3ddee591a4d2492385a9f0b07bf27"}}, "title": "Twinning during the pandemic: Evidence of selection in utero.", "authors": [{"family": "Catalano", "given": "Ralph", "initials": "R", "orcid": "0000-0001-7240-415X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ccf81f67c4f46dc92acca88a7344cc9.json"}}, {"family": "Bruckner", "given": "Tim", "initials": "T"}, {"family": "Casey", "given": "Joan A", "initials": "JA"}, {"family": "Gemmill", "given": "Alison", "initials": "A", "orcid": "0000-0001-5879-9730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dca36e3db9724dce8360c5f7b362151d.json"}}, {"family": "Margerison", "given": "Claire", "initials": "C", "orcid": "0000-0003-0692-2252", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06be6014da274b2886af1733870d98b0.json"}}, {"family": "Hartig", "given": "Terry", "initials": "T"}], "type": "journal article", "published": "2021-10-20", "journal": {"title": "Evol Med Public Health", "issn": "2050-6201", "volume": "9", "issue": "1", "pages": "374-382", "issn-l": null}, "abstract": "The suspicion that a population stressor as profound as the COVID-19 pandemic would increase preterm birth among cohorts in gestation at its outset has not been supported by data collected in 2020. An evolutionary perspective on this circumstance suggests that natural selection in utero, induced by the onset of the pandemic, caused pregnancies that would otherwise have produced a preterm birth to end early in gestation as spontaneous abortions. We test this possibility using the odds of a live-born twin among male births in Norway as an indicator of the depth of selection in birth cohorts.\n\nWe apply Box-Jenkins methods to 50 pre-pandemic months to estimate counterfactuals for the nine birth cohorts in gestation in March 2020 when the first deaths attributable to SARS-CoV-2 infection occurred in Norway. We use Alwan and Roberts outlier detection methods to discover any sequence of outlying values in the odds of a live-born twin among male births in exposed birth cohorts.\n\nWe find a downward level shift of 27% in the monthly odds of a twin among male births beginning in May and persisting through the remainder of 2020.\n\nConsistent with evolutionary theory and selection in utero, birth cohorts exposed in utero to the onset of the COVID-19 pandemic yielded fewer male twins than expected.\n\nOur finding of fewer than expected male twin births during the onset of the COVID-19 pandemic provides more evidence that evolution continues to affect the characteristics and health of contemporary populations.", "doi": "10.1093/emph/eoab033", "pmid": "34858596", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "eoab033"}, {"db": "pmc", "key": "PMC8634460"}], "notes": [], "created": "2021-12-18T18:06:55.901Z", "modified": "2021-12-18T18:07:03.516Z"}, {"entity": "publication", "iuid": "c10ab7f808754f1a8e2812b74e8a7985", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c10ab7f808754f1a8e2812b74e8a7985.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c10ab7f808754f1a8e2812b74e8a7985"}}, "title": "Trends of Anger and Physical Aggression in Russian Women During COVID-19 Lockdown.", "authors": [{"family": "Klimovich-Mickael", "given": "Alexandra", "initials": "A"}, {"family": "Kubick", "given": "Norwin", "initials": "N"}, {"family": "Milanesi", "given": "Elena", "initials": "E"}, {"family": "Dobre", "given": "Maria", "initials": "M"}, {"family": "\u0141azarczyk", "given": "Marzena", "initials": "M"}, {"family": "Wijas", "given": "Baraba", "initials": "B"}, {"family": "Sacharczuk", "given": "Mariusz", "initials": "M"}, {"family": "Mickael", "given": "Michel-Edwar", "initials": "ME"}], "type": "journal article", "published": "2021-10-20", "journal": {"title": "Front Glob Womens Health", "issn": "2673-5059", "volume": "2", "pages": "698151", "issn-l": null}, "abstract": "The effect of social lockdown during the COVID-19 outbreak on female aggressiveness is not well known. The strict measures of lockdown have resulted in millions of people, worldwide, confined to their homes during the pandemic. However, the consequence of lockdown strategies on females' psychological status including aggressiveness has not yet been investigated. We conducted a cross-sectional study on 31 Russian females' homemakers who are participants in an online fitness platform to investigate the immediate anxiety, depression, and aggression experienced under strict lockdown measures. The participants were surveyed using the hospital anxiety depression scale (HADS) and the Buss-Perry Aggression Questionnaire. We used descriptive and statistical methods to investigate the prevalence of these emotions among two age groups (20-35 and 36-65 years). We found that moderate anxiety prevalence was 77.4% in the entire group while mild depression was 54.8%. Interestingly, the whole sample showed a high level of angriness (p = 0.0002) and physical aggression (p = 0.019). These two emotions seem to be more prevalent than other negative emotions such as hostility, verbal aggression. This relationship was not dependent on age. Overall, there is a significant worsening in female aggression that could lead to higher chances of female victimization and being subjected to partner violence. Future policies designing lockdown strategies should consider this effect on active female homemakers. Due to the small size of our cohort, our results are only indicative of data trends. Larger studies are still needed to confirm the current findings.", "doi": "10.3389/fgwh.2021.698151", "pmid": "34816235", "labels": {"Type: Journal article": null, "Topics: Register-based research": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8593940"}], "notes": [], "created": "2021-11-26T13:17:10.899Z", "modified": "2021-12-18T18:23:22.161Z"}, {"entity": "publication", "iuid": "475cebda2a5f43bc9184f6963321058d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/475cebda2a5f43bc9184f6963321058d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/475cebda2a5f43bc9184f6963321058d"}}, "title": "Socio-economic and psychological impact of COVID-19 pandemic in a Spanish cohort BIOVAL-D-COVID-19 study protocol.", "authors": [{"family": "Miranda-Mendizabal", "given": "Andrea", "initials": "A"}, {"family": "Recoder", "given": "Silvia", "initials": "S"}, {"family": "Sebastian", "given": "Ester Calbo", "initials": "EC"}, {"family": "Casajuana Closas", "given": "Marc", "initials": "M"}, {"family": "Leiva Ure\u00f1a", "given": "David", "initials": "D"}, {"family": "Manolov", "given": "Rumen", "initials": "R"}, {"family": "Matilla Santander", "given": "Nuria", "initials": "N"}, {"family": "Forero", "given": "Carlos G", "initials": "CG"}, {"family": "Castellv\u00ed", "given": "Pere", "initials": "P"}], "type": "journal article", "published": "2021-10-20", "journal": {"title": "Gac Sanit", "issn": "1578-1283", "issn-l": null}, "abstract": "SARS-CoV-2 outbreak has a negative psychological impact among general population. Data comparing mental health status before and during the outbreak is needed. The BIOVAL-D-COVID-19 study assess the socio-economic and psychological impact of the COVID-19 pandemic and lockdown in a representative sample of non-institutionalized Spanish adult population, and estimate the incidence of mental health disorders, including suicidal behaviours, and possible related factors.\n\nObservational longitudinal study including two online surveys: baseline survey (T0) performed during 2019 and follow-up survey (T1) conducted 12-month later. The latter included nine sections: socio-demographic, health status, mental health, employment conditions and status, material deprivation, use of healthcare services, intimate partner violence and resilience. Four of the nine sections are administered in T0 and T1 assessments. Longitudinal data analyses will estimate adjusted incidence rates of mental health disorders using Poisson regression models. Risk and protective factors will be analysed through multiple logistic regression models.", "doi": "10.1016/j.gaceta.2021.10.003", "pmid": "34836679", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0213-9111(21)00180-1"}, {"db": "pmc", "key": "PMC8526442"}], "notes": [], "created": "2021-12-18T18:13:46.340Z", "modified": "2021-12-18T18:14:03.345Z"}, {"entity": "publication", "iuid": "5ac427dcbd894ef981cceb9d3f478952", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5ac427dcbd894ef981cceb9d3f478952.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5ac427dcbd894ef981cceb9d3f478952"}}, "title": "Gender gap in journal submissions and peer review during the first wave of the COVID-19 pandemic. A study on 2329 Elsevier journals.", "authors": [{"family": "Squazzoni", "given": "Flaminio", "initials": "F", "orcid": "0000-0002-6503-6077", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b124ceca40884addab841186835c2e43.json"}}, {"family": "Bravo", "given": "Giangiacomo", "initials": "G", "orcid": "0000-0003-2837-0137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e2bd815dac24aabb080893c4d7d1051.json"}}, {"family": "Grimaldo", "given": "Francisco", "initials": "F", "orcid": "0000-0002-1357-7170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6be3f24db5f44f26ae1ed1fb16c5b760.json"}}, {"family": "Garc\u00eda-Costa", "given": "Daniel", "initials": "D"}, {"family": "Farjam", "given": "Mike", "initials": "M"}, {"family": "Mehmani", "given": "Bahar", "initials": "B", "orcid": "0000-0003-4038-4531", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bbbcfa3265dc4cd6a804e4515137ee1f.json"}}], "type": "journal article", "published": "2021-10-20", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0257919", "issn-l": "1932-6203"}, "abstract": "During the early months of the COVID-19 pandemic, there was an unusually high submission rate of scholarly articles. Given that most academics were forced to work from home, the competing demands for familial duties may have penalized the scientific productivity of women. To test this hypothesis, we looked at submitted manuscripts and peer review activities for all Elsevier journals between February and May 2018-2020, including data on over 5 million authors and referees. Results showed that during the first wave of the pandemic, women submitted proportionally fewer manuscripts than men. This deficit was especially pronounced among more junior cohorts of women academics. The rate of the peer-review invitation acceptance showed a less pronounced gender pattern with women taking on a greater service responsibility for journals, except for health & medicine, the field where the impact of COVID-19 research has been more prominent. Our findings suggest that the first wave of the pandemic has created potentially cumulative advantages for men.", "doi": "10.1371/journal.pone.0257919", "pmid": "34669713", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-15330"}], "notes": [], "created": "2021-10-21T04:37:34.903Z", "modified": "2021-10-21T04:37:35.057Z"}, {"entity": "publication", "iuid": "1992a95857644f16a0b3f26aeb5ed5af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1992a95857644f16a0b3f26aeb5ed5af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1992a95857644f16a0b3f26aeb5ed5af"}}, "title": "COVID-19: A comprehensive review of current guidelines and personal perspectives from neurointerventionists.", "authors": [{"family": "Lee", "given": "Seon-Kyu", "initials": "SK"}, {"family": "S\u00f6derman", "given": "Michael", "initials": "M"}, {"family": "Altschul", "given": "David J", "initials": "DJ", "orcid": "0000-0002-5130-1378", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8b7025f25174eec917fe4491b64765d.json"}}], "type": "journal article", "published": "2021-10-20", "journal": {"title": "Interv Neuroradiol", "issn": "2385-2011", "pages": "15910199211037807", "issn-l": null}, "abstract": null, "doi": "10.1177/15910199211037807", "pmid": "34669531", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-10-21T04:38:02.457Z", "modified": "2021-10-21T04:38:17.971Z"}, {"entity": "publication", "iuid": "cc6244441ef447f6834249322c7adfc4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc6244441ef447f6834249322c7adfc4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc6244441ef447f6834249322c7adfc4"}}, "title": "The role of ventilatory support for long-term outcomes after critical infection with COVID-19: A prospective cohort study.", "authors": [{"family": "Hanna", "given": "Gabriel", "initials": "G"}, {"family": "Bankler", "given": "Sara", "initials": "S"}, {"family": "Schandl", "given": "Anna", "initials": "A"}, {"family": "Ro\u00ebl", "given": "Mari", "initials": "M"}, {"family": "Hedman", "given": "Anders", "initials": "A"}, {"family": "Franko", "given": "Mikael Andersson", "initials": "MA"}, {"family": "Lyng\u00e5", "given": "Patrik", "initials": "P"}, {"family": "Geborek", "given": "Anne", "initials": "A"}, {"family": "Joelsson-Alm", "given": "Eva", "initials": "E", "orcid": "0000-0002-9041-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07a091265e654b21bc27fa14b93e4ec0.json"}}, {"family": "S\u00f6derberg", "given": "M\u00e5rten", "initials": "M"}, {"family": "Darlington", "given": "Pernilla", "initials": "P"}], "type": "journal article", "published": "2021-10-19", "journal": {"title": "Clin Respir J", "issn": "1752-699X", "issn-l": null}, "abstract": "The full range of long-term health consequences in ICU survivors with COVID-19 is unclear. This study aims to investigate the role of ventilatory support for long-term pulmonary impairment in critically ill patients and further to identify risk factors for prolonged radiological recovery.\n\nA prospective observational study from a single general hospital, including all with COVID-19 admitted to ICU between March and August 2020, investigating the association between ventilatory support and the extent of residual parenchymal changes on chest CT scan and measurement of lung volumes at follow-up comparing high-flow nasal oxygen (HFNO) or non-invasive ventilation (NIV) with invasive ventilation. A semi-quantitative score (CT involvement score) based on lobar involvement and a total score for all five lobes was used to estimate residual parenchymal changes. The association was calculated with logistic regression and adjusted for age, sex, smoking and severity of illness.\n\nAmong the 187 eligible, 86 had a chest CT scan and 76 a pulmonary function test at the follow-up with a median time of six months after ICU discharge. Residual lung changes were seen in 74%. The extent of pulmonary changes was similar regardless of ventilatory support, but patients with invasive ventilation had a lower total lung capacity 84% vs 92% of predicted (p<0.001).\n\nThe majority of ICU-treated patients with COVID-19 had residual lung changes at six months follow-up regardless of ventilator support or not, but the total lung capacity was lower in those treated with invasive ventilation.", "doi": "10.1111/crj.13453", "pmid": "34665518", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-21T04:53:21.266Z", "modified": "2021-10-21T04:53:21.356Z"}, {"entity": "publication", "iuid": "8d53640d5b78486ba15544de1fdba5cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d53640d5b78486ba15544de1fdba5cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d53640d5b78486ba15544de1fdba5cf"}}, "title": "Social Distancing Policies in the Coronavirus Battle: A Comparison of Denmark and Sweden.", "authors": [{"family": "Seing", "given": "Ida", "initials": "I"}, {"family": "Th\u00f3rn\u00fd Stef\u00e1nsd\u00f3ttir", "given": "Nina", "initials": "N", "orcid": "0000-0002-7748-5347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c7da04bf6284cab9a62b9d6faf64b06.json"}}, {"family": "Wassar Kirk", "given": "Jeanette", "initials": "J", "orcid": "0000-0002-2680-0917", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f32255961c141298acfba1fbaac9824.json"}}, {"family": "Andersen", "given": "Ove", "initials": "O"}, {"family": "Tj\u00f8rnh\u00f8j-Thomsen", "given": "Tine", "initials": "T"}, {"family": "Kallemose", "given": "Thomas", "initials": "T"}, {"family": "Vedung", "given": "Evert", "initials": "E"}, {"family": "Vrangb\u00e6k", "given": "Karsten", "initials": "K"}, {"family": "Nilsen", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2021-10-19", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "20", "pages": null}, "abstract": "Social distancing measures have been a key component in government strategies to mitigate COVID-19 globally. Based on official documents, this study aimed to identify, compare and analyse public social distancing policy measures adopted in Denmark and Sweden regarding the coronavirus from 1 March 2020 until 1 October 2020. A key difference was the greater emphasis on laws and executive orders (sticks) in Denmark, which allowed the country to adopt many stricter policy measures than Sweden, which relied mostly on general guidelines and recommendations (sermons). The main policy adopters in Denmark were the government and the Danish Parliament, whereas the Public Health Agency issued most policies in Sweden, reflecting a difference in political governance and administrative structure in the two countries. During the study period, Sweden had noticeably higher rates of COVID-19 deaths and hospitalizations per 100,000 population than Denmark, yet it is difficult to determine the impact or relative effectiveness of sermons and sticks, particularly with regard to broader and longer-term health, economic and societal effects.", "doi": "10.3390/ijerph182010990", "pmid": "34682734", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182010990"}], "notes": [], "created": "2021-10-26T18:16:33.651Z", "modified": "2022-02-17T12:04:44.526Z"}, {"entity": "publication", "iuid": "ba97b2dc080946b7997eb15dcd2e098f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ba97b2dc080946b7997eb15dcd2e098f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ba97b2dc080946b7997eb15dcd2e098f"}}, "title": "Lack of Trust, Insufficient knowledge and Risk denial; an in-depth Understanding of Health workers Barriers to uptake of the Covid-19 vaccine at Iganga Hospital Eastern Uganda, and Mengo Hospital Kampala Uganda", "authors": [{"family": "Muhamadi", "given": "Lubega", "initials": "L"}, {"family": "Edith", "given": "Namulema", "initials": "N"}, {"family": "James", "given": "Waako", "initials": "W"}, {"family": "Tumwesigye", "given": "Nazarius Mbona", "initials": "NM"}, {"family": "Museene", "given": "Safinah Kisu", "initials": "SK"}, {"family": "Mukakaarisa", "given": "Hellen", "initials": "H"}, {"family": "Peterson", "given": "Stefan Swartling", "initials": "SS"}, {"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM"}], "type": "posted-content", "published": "2021-10-19", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.10.13.21264920", "pmid": null, "labels": {"Category: Public Health": null, "Type: Preprint": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:41:01.093Z", "modified": "2021-11-29T06:08:28.303Z"}, {"entity": "publication", "iuid": "4efc878827a54611ba59ad34ee90434b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4efc878827a54611ba59ad34ee90434b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4efc878827a54611ba59ad34ee90434b"}}, "title": "Impact of SARS-CoV-2 infection on vaccine-induced immune responses over time", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Ng", "given": "Henry", "initials": "H"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "posted-content", "published": "2021-10-19", "journal": {"title": "MedRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.10.16.21264948", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Health": null, "Research Area: High-throughput and high-content serology": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-11-18T16:32:34.201Z", "modified": "2023-06-19T14:28:13.106Z"}, {"entity": "publication", "iuid": "14d8fb377fab4b9ba81680ee27e65d48", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/14d8fb377fab4b9ba81680ee27e65d48.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/14d8fb377fab4b9ba81680ee27e65d48"}}, "title": "Humoral and cellular response to SARS-CoV-2 BNT162b2 mRNA vaccine in hemodialysis patients.", "authors": [{"family": "Melin", "given": "Jan", "initials": "J", "orcid": "0000-0003-3405-3154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e749d7c3ad7e40cfbb1f3bfda19ec05b.json"}}, {"family": "Svensson", "given": "Maria K", "initials": "MK"}, {"family": "Albinsson", "given": "Bo", "initials": "B"}, {"family": "Winqvist", "given": "Ola", "initials": "O"}, {"family": "Pauksens", "given": "Karlis", "initials": "K"}], "type": "journal article", "published": "2021-10-19", "journal": {"title": "BMC Immunol", "issn": "1471-2172", "issn-l": null, "volume": "22", "issue": "1", "pages": "70"}, "abstract": "Hemodialysis (HD) patients have an increased risk of acquiring infections due to many health care contacts and may, in addition, have a suboptimal response to vaccination and a high mortality from Covid-19 infection.\n\nIn 50 HD patients (mean age 69.4 years, 62% men) administration of SARS-CoV-2BNT162b2 mRNA vaccine began in Dec 2020 and the immune response was evaluated 7-15 weeks after the last dose. Levels of Covid-19 (SARS-CoV-2) IgG antibody against the nucleocapsid antigen (anti-N) and the Spike antigen (anti-S) and T-cell reactivity testing against the Spike protein using ELISPOT technology were evaluated.\n\nOut of 50 patients, anti-S IgG antibodies indicating a vaccine effect or previous Covid-19 infection, were detected in 37 (74%), 5 (10%) had a borderline response and 8 (16%) were negative after two doses of vaccine. T-cell responses were detected in 29 (58%). Of the 37 patients with anti-S antibodies, 25 (68%) had a measurable T-cell response. 2 (40%) out of 5 patients with borderline anti-S and 2 (25%) without anti-S had a concomitant T-cell response. Twenty-seven (54%) had both an antibody and T-cell response. IgG antibodies to anti-N indicating a previous Covid-19 disease were detected in 7 (14%) patients.\n\nMost HD patients develop a B- and/or T-cell response after vaccination against Covid-19 but approx. 20% had a limited immunological response. T-cell reactivity against Covid-19 was only present in a few of the anti-S antibody negative patients.", "doi": "10.1186/s12865-021-00458-0", "pmid": "34666683", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC8524400"}, {"db": "pii", "key": "10.1186/s12865-021-00458-0"}], "notes": [], "created": "2021-10-21T04:48:27.665Z", "modified": "2023-06-19T15:31:31.358Z"}, {"entity": "publication", "iuid": "f33dd0f2b2b84264b595cd9fd28bff7c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f33dd0f2b2b84264b595cd9fd28bff7c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f33dd0f2b2b84264b595cd9fd28bff7c"}}, "title": "Drug repurposing improves disease targeting 11-fold and can be augmented by network module targeting, applied to COVID-19.", "authors": [{"family": "Rivero-Garc\u00eda", "given": "In\u00e9s", "initials": "I"}, {"family": "Castresana-Aguirre", "given": "Miguel", "initials": "M"}, {"family": "Guglielmo", "given": "Luca", "initials": "L"}, {"family": "Guala", "given": "Dimitri", "initials": "D"}, {"family": "Sonnhammer", "given": "Erik L L", "initials": "ELL"}], "type": "journal article", "published": "2021-10-19", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "20687", "issn-l": "2045-2322"}, "abstract": "This analysis presents a systematic evaluation of the extent of therapeutic opportunities that can be obtained from drug repurposing by connecting drug targets with disease genes. When using FDA-approved indications as a reference level we found that drug repurposing can offer an average of an 11-fold increase in disease coverage, with the maximum number of diseases covered per drug being increased from 134 to 167 after extending the drug targets with their high confidence first neighbors. Additionally, by network analysis to connect drugs to disease modules we found that drugs on average target 4 disease modules, yet the similarity between disease modules targeted by the same drug is generally low and the maximum number of disease modules targeted per drug increases from 158 to 229 when drug targets are neighbor-extended. Moreover, our results highlight that drug repurposing is more dependent on target proteins being shared between diseases than on polypharmacological properties of drugs. We apply our drug repurposing and network module analysis to COVID-19 and show that Fostamatinib is the drug with the highest module coverage.", "doi": "10.1038/s41598-021-99721-y", "pmid": "34667255", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-99721-y"}, {"db": "URL", "key": "https://bitbucket.org/sonnhammergroup/unadrug", "description": "Code, raw data, analysis results, and figures are all available in bitbucket"}], "notes": [], "created": "2021-10-21T04:41:29.287Z", "modified": "2021-11-08T09:51:37.313Z"}, {"entity": "publication", "iuid": "c2942d61f471452ba1028a411f33f4a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2942d61f471452ba1028a411f33f4a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2942d61f471452ba1028a411f33f4a9"}}, "title": "Cardiorespiratory fitness and lifestyle on severe COVID-19 risk in 279,455 adults: a case control study.", "authors": [{"family": "Ekblom-Bak", "given": "Elin", "initials": "E", "orcid": "0000-0002-3901-7833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08a43b5b45864543a2583be45a2f1d10.json"}}, {"family": "V\u00e4is\u00e4nen", "given": "Daniel", "initials": "D"}, {"family": "Ekblom", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Blom", "given": "Victoria", "initials": "V"}, {"family": "Kallings", "given": "Lena V", "initials": "LV"}, {"family": "Hemmingsson", "given": "Erik", "initials": "E"}, {"family": "Andersson", "given": "Gunnar", "initials": "G"}, {"family": "Wallin", "given": "Peter", "initials": "P"}, {"family": "Salier Eriksson", "given": "Jane", "initials": "J"}, {"family": "Holmlund", "given": "Tobias", "initials": "T"}, {"family": "Lindwall", "given": "Magnus", "initials": "M"}, {"family": "Stenling", "given": "Andreas", "initials": "A"}, {"family": "L\u00f6nn", "given": "Amanda", "initials": "A"}], "type": "journal article", "published": "2021-10-19", "journal": {"title": "Int J Behav Nutr Phys Act", "issn": "1479-5868", "volume": "18", "issue": "1", "pages": "135", "issn-l": null}, "abstract": "The impact of cardiorespiratory fitness (CRF) and other lifestyle-related factors on severe COVID-19 risk is understudied. The present study aims to investigate lifestyle-related and socioeconomic factors as possible predictors of COVID-19, with special focus on CRF, and to further study whether these factors may attenuate obesity- and hypertension-related risks, as well as mediate associations between socioeconomic factors and severe COVID-19 risk.\n\nOut of initially 407,131 participants who participated in nationwide occupational health service screening between 1992 and 2020, n = 857 cases (70% men, mean age 49.9 years) of severe COVID-19 were identified. CRF was estimated using a sub-maximum cycle test, and other lifestyle variables were self-reported. Analyses were performed including both unmatched, n = 278,598, and sex-and age-matched, n = 3426, controls. Severe COVID-19 included hospitalization, intensive care or death due to COVID-19.\n\nPatients with more severe COVID-19 had significantly lower CRF, higher BMI, a greater presence of comorbidities and were more often daily smokers. In matched analyses, there was a graded decrease in odds for severe COVID-19 with each ml in CRF (OR = 0.98, 95% CI 0.970 to 0.998), and a two-fold increase in odds between the lowest and highest (< 32 vs. \u2265 46 ml\u00b7min-1\u00b7kg-1) CRF group. Higher BMI (per unit increase, OR = 1.09, 1.06 to 1.12), larger waist circumference (per cm, OR = 1.04, 1.02 to 1.06), daily smoking (OR = 0.60, 0.41 to 0.89) and high overall stress (OR = 1.36, 1.001 to 1.84) also remained significantly associated with severe COVID-19 risk. Obesity- and blood pressure-related risks were attenuated by adjustment for CRF and lifestyle variables. Mediation through CRF, BMI and smoking accounted for 9% to 54% of the associations between low education, low income and blue collar/low skilled occupations and severe COVID-19 risk. The results were consistent using either matched or unmatched controls.\n\nBoth lifestyle-related and socioeconomic factors were associated with risk of severe COVID-19. However, higher CRF attenuated the risk associated with obesity and high blood pressure, and mediated the risk associated with various socioeconomic factors. This emphasises the importance of interventions to maintain or increase CRF in the general population to strengthen the resilience to severe COVID-19, especially in high-risk individuals.", "doi": "10.1186/s12966-021-01198-5", "pmid": "34666788", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12966-021-01198-5"}], "notes": [], "created": "2021-10-21T04:47:47.784Z", "modified": "2021-10-21T04:47:47.858Z"}, {"entity": "publication", "iuid": "78490315e34845a5b5594d5e796d14d6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/78490315e34845a5b5594d5e796d14d6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/78490315e34845a5b5594d5e796d14d6"}}, "title": "COVID-19 mortality across occupations and secondary risks for elderly individuals in the household: A population register-based study.", "authors": [{"family": "Billingsley", "given": "Sunnee", "initials": "S"}, {"family": "Brand\u00e9n", "given": "Maria", "initials": "M"}, {"family": "Aradhya", "given": "Siddartha", "initials": "S"}, {"family": "Drefahl", "given": "Sven", "initials": "S"}, {"family": "Andersson", "given": "Gunnar", "initials": "G"}, {"family": "Mussino", "given": "Eleonora", "initials": "E"}], "type": "journal article", "published": "2021-10-19", "journal": {"title": "Scand J Work Environ Health", "issn": "1795-990X", "issn-l": null}, "abstract": "Objectives This is the first population-level study to examine inequalities in COVID-19 mortality according to working-age individuals' occupations and the indirect occupational effects on COVID-19 mortality of older individuals who live with them. Methods We used early-release data for the entire population of Sweden of all recorded COVID-19 deaths from 12 March 2020 to 23 February 2021, which we linked to administrative registers and occupational measures. Cox proportional hazard models assessed relative risks of COVID-19 mortality for the working-aged population registered in an occupation in December 2018 and the older population who lived with them. Results Among working aged-adults, taxi/bus drivers had the highest relative risk of COVID-19 mortality: over four times that of skilled workers in IT, economics, or administration when adjusted only for basic demographic characteristics. After adjusting for socioeconomic factors (education, income and country of birth), there are no occupational groups with clearly elevated (statistically significant) COVID-19 mortality. Neither a measure of exposure within occupations nor the share that generally can work from home were related to working-aged adults' risk of COVID-19 mortality. Instead of occupational factors, traditional socioeconomic risk factors best explained variation in COVID-19 mortality. Elderly individuals, however, faced higher COVID-19 mortality risk both when living with a delivery or postal worker or worker(s) in occupations that generally work from home less, even when their socioeconomic factors are taken into account. Conclusions Inequalities in COVID-19 mortality of working-aged adults were mostly based on traditional risk factors and not on occupational divisions or characteristics in Sweden. However, older individuals living with those who likely cannot work from home or work in delivery or postal services were a vulnerable group.", "doi": "10.5271/sjweh.3992", "pmid": "34665872", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "3992"}], "notes": [], "created": "2021-10-21T04:50:35.692Z", "modified": "2021-10-21T04:50:35.707Z"}, {"entity": "publication", "iuid": "d8ef63726b3b45bcb96b054a6655d41e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d8ef63726b3b45bcb96b054a6655d41e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d8ef63726b3b45bcb96b054a6655d41e"}}, "title": "Role and utility of COVID-19 laboratory testing in low-income and middle-income countries: protocol for rapid evidence synthesis.", "authors": [{"family": "Ouma", "given": "Ojiambo Kevin", "initials": "OK"}, {"family": "Ephraim", "given": "Kisangala", "initials": "K"}, {"family": "Loyce", "given": "Nakalembe", "initials": "N"}, {"family": "Namisango", "given": "Eve", "initials": "E"}, {"family": "Nalugoda", "given": "Fred", "initials": "F"}, {"family": "Ndagire", "given": "Regina", "initials": "R"}, {"family": "Wangi", "given": "Rachel Nante", "initials": "RN", "orcid": "0000-0002-6589-2535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1b0dbf50f5f4bbaafb75643f527f0ca.json"}}, {"family": "Kawala", "given": "Brenda Allen", "initials": "BA"}, {"family": "Katairo", "given": "Thomas", "initials": "T", "orcid": "0000-0002-2002-8911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6711071ed8b0441d94f931c7ae884683.json"}}, {"family": "Okullo", "given": "Allen Eva", "initials": "AE"}, {"family": "Apunyo", "given": "Robert", "initials": "R"}, {"family": "Semakula", "given": "Daniel", "initials": "D", "orcid": "0000-0002-0806-213X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ed9d8d3a7aa44ad8443b2310f58fbd7.json"}}, {"family": "Luwambo", "given": "Ash", "initials": "A"}, {"family": "Kinengyere", "given": "Alison Annet", "initials": "AA"}, {"family": "Sewankambo", "given": "Nelson", "initials": "N"}, {"family": "Balinda", "given": "Sheila N", "initials": "SN"}, {"family": "Ocan", "given": "Moses", "initials": "M", "orcid": "0000-0002-8852-820X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de5a2ad5cc524e91851f35ea9ff821b3.json"}}, {"family": "Obuku", "given": "Ekwaro A", "initials": "EA"}], "type": "journal article", "published": "2021-10-18", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "10", "pages": "e050296", "issn-l": "2044-6055"}, "abstract": "Accurate and affordable laboratory testing is key to timely diagnosis and appropriate management of patients with COVID-19. New laboratory test protocols are released into the market under emergency use authorisation with limited evidence on diagnostic test accuracy. As such, robust evidence on the diagnostic accuracy and the costs of available tests is urgently needed to inform policy and practice especially in resource-limited settings. We aim to determine the diagnostic test accuracy, cost-effectiveness and utility of laboratory test strategies for COVID-19 in low-income and middle-income countries.\n\nThis will be a multistaged, protocol-driven systematic review conducted in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for diagnostic test accuracy studies. We will search for relevant literature in at least six public health databases, including PubMed, Google Scholar, MEDLINE, Scopus, Web of Science and the WHO Global Index Medicus. In addition, we will search Cochrane Library, COVID-END and grey literature databases to identify additional relevant articles before double-screening and abstraction of data. We will conduct a structured narrative and quantitative synthesis of the results guided by the Fryback and Thornbury framework for assessing a diagnostic test. The primary outcome is COVID-19 diagnostic test accuracy. Using the GRADE approach specific to diagnostic accuracy tests, we will appraise the overall quality of evidence and report the results following the original PRISMA statement. The protocol is registered with the International Prospective Register of Systematic Reviews (PROSPERO; https://www.crd.york.ac.uk/prospero/).\n\nEthical review was done by the School of Biomedical Sciences Research Ethics Committee and the Uganda National Council for Science and Technology. The published article will be accessible to policy and decision makers. The findings of this review will guide clinical practice and policy decisions and highlight areas for future research.PROSPERO registration number CRD42020209528.", "doi": "10.1136/bmjopen-2021-050296", "pmid": "34663660", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-050296"}], "notes": [], "created": "2021-10-21T04:58:00.330Z", "modified": "2021-10-21T04:58:09.820Z"}, {"entity": "publication", "iuid": "be07526407fe48d398cc79e1536de2d3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be07526407fe48d398cc79e1536de2d3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be07526407fe48d398cc79e1536de2d3"}}, "title": "Migrant workers occupational health research: an OMEGA-NET working group position paper.", "authors": [{"family": "Aktas", "given": "Emine", "initials": "E", "orcid": "0000-0003-2635-7588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e067735686ea462ead1cbe50348d7c04.json"}}, {"family": "Bergbom", "given": "Barbara", "initials": "B", "orcid": "0000-0002-5245-6419", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18083a7cae13485b94ec1cb2a36ea810.json"}}, {"family": "Godderis", "given": "Lode", "initials": "L", "orcid": "0000-0003-4764-8835", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/639b8bdac78742e9aeebe5b33c6dfedb.json"}}, {"family": "Kreshpaj", "given": "Bertina", "initials": "B", "orcid": "0000-0002-2991-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d89b188538b64d6ca022b92c85cd0cf1.json"}}, {"family": "Marinov", "given": "Mario", "initials": "M"}, {"family": "Mates", "given": "Dana", "initials": "D"}, {"family": "McElvenny", "given": "Damien M", "initials": "DM", "orcid": "0000-0003-0953-8336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ffabe7c996ff4f47af509448b20dff49.json"}}, {"family": "Mehlum", "given": "Ingrid Sivesind", "initials": "IS", "orcid": "0000-0003-0830-284X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2366026a9d564a11b0bac13f7a8d3115.json"}}, {"family": "Milenkova", "given": "Valentina", "initials": "V"}, {"family": "Nena", "given": "Evangelia", "initials": "E", "orcid": "0000-0003-0381-4715", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d0b80af9262c45bbaff8afbefc515733.json"}}, {"family": "Glass", "given": "Deborah C", "initials": "DC", "orcid": "0000-0002-7559-008X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1185128471f4cc090044359d8df3b5d.json"}}], "type": "journal article", "published": "2021-10-18", "journal": {"title": "Int Arch Occup Environ Health", "issn": "1432-1246", "issn-l": null}, "abstract": "The aims of the study were: (1) to clarify the definitions of \"migrant\" used in occupational health research; (2) to summarize migrant workers' industry sectors, occupations and employment conditions; (3) to identify the occupational health and safety services available to migrant workers; (4) to summarize work-related health problems found among migrant workers; (5) to identify the methodological challenges to research into occupational health of migrant workers; and (6) to recommend improvements in migrant occupational health research.\n\nThis position paper was prepared by researchers from several European countries and Australia, working within the EU COST Action OMEGA-NET. The paper drew on two recent systematic reviews on the occupational health of international migrant workers and other literature, and also identified uncertainties and gaps in the research literature. Migrants may, for example, be temporary or permanent, moving for specific jobs migrants or other reasons. Their ethnicity and language capabilities will affect their work opportunities.\n\nThe occupational health literature seldom adequately identifies the heterogeneity or characteristics of the migrant group being studied. Migrants tend to work in more physically and mentally demanding environments with higher exposures than native workers. Migrants tend to have an increased risk of physical and mental ill health, but less access to health care services. This has been demonstrated recently by high rates of COVID-19 and less access to health care. There have been a number of cross-sectional studies of migrant health but few long-term cohort studies were identified. Other study designs, such as registry-based studies, surveys and qualitative studies may complement cross-sectional studies. Mixed-methodology studies would be valuable in research on migrants' occupational health. Language and lack of trust are barriers to migrant research participation.\n\nTargeted research, especially longitudinal, identifying how these economically important but often-vulnerable workers can be best assisted is needed. Researchers should identify the characteristics of the migrant workers that they are studying including visa/migration circumstances (temporary, permanent, undocumented), racial and ethnic characteristics, existing skills and language abilities.", "doi": "10.1007/s00420-021-01803-x", "pmid": "34661721", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00420-021-01803-x"}], "notes": [], "created": "2021-10-21T04:59:08.484Z", "modified": "2021-10-21T04:59:08.786Z"}, {"entity": "publication", "iuid": "d1e27ffd876749519ad5c92de8ceb231", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1e27ffd876749519ad5c92de8ceb231.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1e27ffd876749519ad5c92de8ceb231"}}, "title": "How the COVID-19 pandemic affects transgender health care - A cross-sectional online survey in 63 upper-middle-income and high-income countries.", "authors": [{"family": "Koehler", "given": "Andreas", "initials": "A", "orcid": "0000-0003-0415-3007", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6f71cad12f54442b7c37a3ca124148b.json"}}, {"family": "Motmans", "given": "Joz", "initials": "J", "orcid": "0000-0001-7643-4153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e84b4ee717654f5d9e0c102cb396a249.json"}}, {"family": "Muli\u00f3 Alvarez", "given": "Leo", "initials": "L"}, {"family": "Azul", "given": "David", "initials": "D", "orcid": "0000-0002-9181-8582", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/843fa6d772084e38a549235a1c80cc75.json"}}, {"family": "Badalyan", "given": "Karen", "initials": "K"}, {"family": "Basar", "given": "Koray", "initials": "K"}, {"family": "Dhejne", "given": "Cecilia", "initials": "C"}, {"family": "Dui\u0161in", "given": "Dragana", "initials": "D"}, {"family": "Grabski", "given": "Bartosz", "initials": "B", "orcid": "0000-0002-6268-2647", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c02c6d9cc5ff44729bb5e1bbc1be6151.json"}}, {"family": "Dufrasne", "given": "Aurore", "initials": "A"}, {"family": "Jokic-Begic", "given": "Natasa", "initials": "N", "orcid": "0000-0003-2597-535X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9bb577af0fc44464a6937b22d3c71524.json"}}, {"family": "Prunas", "given": "Antonio", "initials": "A"}, {"family": "Richards", "given": "Christina", "initials": "C"}, {"family": "Sabir", "given": "Kirill", "initials": "K"}, {"family": "Veale", "given": "Jaimie", "initials": "J"}, {"family": "Nieder", "given": "Timo Ole", "initials": "TO", "orcid": "0000-0003-3052-5169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a8f6f000cf144a293658031d5ff9ba4.json"}}], "type": "journal article", "published": "2021-10-18", "journal": {"title": "Int J Transgend Health", "issn": "2689-5277", "issn-l": null, "volume": "24", "issue": "3", "pages": "346-359"}, "abstract": "Due to the COVID-19 pandemic, access to medical care is restricted for nearly all non-acute conditions. Due to their status as a vulnerable social group and the inherent need for transition-related treatments, transgender people are assumed to be affected particularly severely by the restrictions caused by the COVID-19 pandemic.\r\n\r\nAs an ad hoc collaboration between researchers, clinicians and 23 community organizations, we developed a web-based survey in German that was translated into 26 languages. Participants were recruited via community sources, social media channels, and snowball sampling since May 2020. The present sample is based on the data collected until August 9, 2020. We assessed demographical data, health problems, risk factors, COVID-19 data (e.g., contact history), and the influence of the COVID-19 pandemic on access to transgender health care services. To identify factors associated with the experience of restrictions, we conducted multiple logistic regression analysis.\r\n\r\n5267 transgender people from 63 upper-middle-income and high-income countries participated in the study. Over 50% of the participants had risk factors for a severe course of a COVID-19 infection and were at a high risk of avoiding COVID-19 treatment due to the fear of mistreatment or discrimination. Access to transgender health care services was restricted for 50% of the participants. Male sex assigned at birth and a lower monthly income were significant predictors for the experience of restrictions to health care. 35.0% reported at least one mental health condition and 3.2% have attempted suicide since the beginning of the COVID-19 pandemic.\r\n\r\nTransgender people suffer under the severity of the pandemic due to the intersections between their status as a vulnerable social group, their high number of medical risk factors, and their need for ongoing medical treatment. The COVID-19 pandemic can potentiate these vulnerabilities, add new challenges for transgender people, and, therefore, can lead to devastating consequences, like severe physical or mental health issues, self-harming behavior, and suicidality.", "doi": "10.1080/26895269.2021.1986191", "pmid": "37519919", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10373616"}, {"db": "pii", "key": "1986191"}], "notes": [], "created": "2023-10-04T12:12:44.096Z", "modified": "2023-10-04T13:33:45.009Z"}, {"entity": "publication", "iuid": "0d9c8a32320f4f6981c3a502a9fee2db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d9c8a32320f4f6981c3a502a9fee2db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d9c8a32320f4f6981c3a502a9fee2db"}}, "title": "Effectiveness of heterologous ChAdOx1 nCoV-19 and mRNA prime-boost vaccination against symptomatic Covid-19 infection in Sweden: A nationwide cohort study.", "authors": [{"family": "Nordstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Ballin", "given": "Marcel", "initials": "M"}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-10-18", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "issn-l": null, "volume": null, "issue": null, "pages": "100249"}, "abstract": "The effectiveness of heterologous prime-boost Coronavirus disease 2019 (Covid-19) vaccination is currently unknown.\r\n\r\nFrom individuals vaccinated with two doses against Covid-19 in Sweden until July 5, 2021 (N=3,445,061), we formed a study cohort including 94,569 individuals that had received heterologous ChAdOx1 nCoV-19 / BNT162b2 prime-boost vaccination, 16,402 individuals that received heterologous ChAdOx1 nCoV-19 / mRNA-1273 prime-boost vaccination, and 430,100 individuals that received homologous ChAdOx1 nCoV-19 / ChAdOx1 nCoV-19 prime-boost vaccination. In addition, 180,716 individuals were selected who were unvaccinated at the date of vaccination in the corresponding case. Unvaccinated individuals were censored at first dose of any vaccine. Baseline was the date of the second dose of any vaccine, with the same date in the corresponding unvaccinated individual. The outcome included incident symptomatic Covid-19 infection occurring >14 days after baseline.\r\n\r\nDuring a mean follow-up time of 76 (range 1-183) days, symptomatic Covid-19 infection was confirmed in 187 individuals with heterologous vaccine schedules (incidence rate: 2.0/100,000 person-days) and in 306 individuals from the unvaccinated control group (incidence rate: 7.1/100,000 person-days). The adjusted vaccine effectiveness was 67% (95% CI, 59-73, P<0.001) for heterologous ChAdOx1 nCoV-19 / BNT162b2 prime-boost vaccination, and 79% (95% CI, 62-88, P<0.001) for heterologous ChAdOx1 nCoV-19 / mRNA-1273 prime-boost vaccination. When combined and analysed together, the two heterologous vaccine schedules had an effectiveness of 68% (95% CI, 61-74, P<0.001) which was significantly greater (Pinteraction<0.001) than the 50% effectiveness for homologous ChAdOx1 nCoV-19 / ChAdOx1 nCoV-19 (95% CI, 41-58, P<0.001).\r\n\r\nThe findings of this study suggest that the use of heterologous ChAdOx1 nCoV-19 and mRNA prime-boost vaccination is an effective alternative to increase population immunity against Covid-19, including against the Delta variant which dominated the confirmed cases during the study period. These findings could have important implications for vaccination strategies and logistics, and consequently in the battle against the Covid-19 pandemic.", "doi": "10.1016/j.lanepe.2021.100249", "pmid": "34693387", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00235-0"}, {"db": "pmc", "key": "PMC8520818"}], "notes": [], "created": "2021-10-26T18:25:41.189Z", "modified": "2021-12-07T15:23:48.364Z"}, {"entity": "publication", "iuid": "2f8b9fb8a6854364a925caae0ef582ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2f8b9fb8a6854364a925caae0ef582ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2f8b9fb8a6854364a925caae0ef582ee"}}, "title": "Pregnancy and risk of COVID-19: a Norwegian registry-linkage study.", "authors": [{"family": "Magnus", "given": "Maria C", "initials": "MC", "orcid": "0000-0002-0568-3774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3530918cfd534021a45a80628c89c580.json"}}, {"family": "Oakley", "given": "Laura", "initials": "L"}, {"family": "Gjessing", "given": "H\u00e5kon K", "initials": "HK"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}, {"family": "Engjom", "given": "Hilde M", "initials": "HM"}, {"family": "Macsali", "given": "Ferenc", "initials": "F"}, {"family": "Juliusson", "given": "Petur B", "initials": "PB"}, {"family": "Andersen", "given": "Anne-Marie Nybo", "initials": "AN"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}], "type": "journal article", "published": "2021-10-17", "journal": {"title": "BJOG", "issn": "1471-0528", "issn-l": null}, "abstract": "To compare the risk of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and contact with specialist health-care services for coronavirus disease 2019 (COVID-19) between pregnant and non-pregnant women.\n\nAll women ages 15 to 45 living in Norway on March 1st , 2020 (N=1,033,699).\n\nWe linked information from the national birth, patient, communicable diseases, and education databases using unique national identifiers.\n\nWe estimated hazard ratios (HR) among pregnant compared to non-pregnant women of having a positive test for SARS-CoV-2, a diagnosis of COVID-19 in specialist healthcare, or hospitalization with COVID-19 using Cox regression. Multivariable analyses adjusted for age, marital status, education, income, country of birth and underlying medical conditions.\n\nPregnant women were not more likely to be tested for or to a have a positive SARS-CoV-2 test (adjusted HR, 0.99; 95% confidence interval [CI]: 0.92-1.07). Pregnant women had higher risk of hospitalization with COVID-19 (HR, 4.70; 95% CI: 3.51- 6.30), and any type of specialist care for COVID-19 (HR, 3.46; 95% CI: 2.89-4.14). Pregnant women born outside Scandinavia were less likely to be tested, and at higher risk of a positive test (HR, 2.37; 95% CI: 2.51-8.87). Compared to pregnant Scandinavian born women, pregnant women with minority background had a higher risk of hospitalization with COVID-19 (HR, 4.72; 95% CI: 2.51-8.87).\n\nPregnant women were not more likely to be infected with SARS-CoV-2. Still, pregnant women with COVID-19, especially those born outside of Scandinavia, were more likely to be hospitalized.", "doi": "10.1111/1471-0528.16969", "pmid": "34657368", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-21T05:02:48.784Z", "modified": "2021-10-21T05:02:48.838Z"}, {"entity": "publication", "iuid": "d68837621db0417dbb9ba64eeaebde42", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d68837621db0417dbb9ba64eeaebde42.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d68837621db0417dbb9ba64eeaebde42"}}, "title": "Cross-cultural prevalence of sleep quality and psychological distress in healthcare workers during COVID-19 pandemic.", "authors": [{"family": "Khan", "given": "Hamza Rafique", "initials": "HR", "orcid": "0000-0002-5914-1444", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd107a2d49c84125bd829a8e32a63af8.json"}}, {"family": "Ashraf", "given": "Farzana", "initials": "F", "orcid": "0000-0003-0110-2618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b5ea851706e4435a5a749b8f25b0147.json"}}, {"family": "Ullah", "given": "Irfan", "initials": "I", "orcid": "0000-0003-1100-101X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8d5a7e15ae6487cbdda0de3b2a531c3.json"}}, {"family": "Tahir", "given": "Muhammad Junaid", "initials": "MJ", "orcid": "0000-0002-0335-6681", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3192523e30b47e4ba6579ed8ab36661.json"}}, {"family": "Dominari", "given": "Asimina", "initials": "A", "orcid": "0000-0002-4023-9767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a082d5a6c7f64a0a982b53edcb22d2d1.json"}}, {"family": "Shoib", "given": "Sheikh", "initials": "S"}, {"family": "Naeem", "given": "Hamna", "initials": "H", "orcid": "0000-0002-3271-9250", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1dba9d91b94e487f84eec592237b73eb.json"}}, {"family": "Reddy", "given": "Gowry", "initials": "G", "orcid": "0000-0003-0774-5809", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5651795d3353483092a191cf52d094b3.json"}}, {"family": "Mukherjee", "given": "Pramit", "initials": "P", "orcid": "0000-0002-8717-2395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a287ee82a04449d8d82230ad0c94fa0.json"}}, {"family": "Akram", "given": "Ifrah", "initials": "I", "orcid": "0000-0002-2737-3224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/983eaa0b255b454b946dda58b4786c04.json"}}, {"family": "Kamada", "given": "Sudha", "initials": "S", "orcid": "0000-0001-8332-8973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/095f77b1995148b5819f6a1c0e14acbb.json"}}, {"family": "Memon", "given": "Roshni Riaz", "initials": "RR", "orcid": "0000-0003-2410-2055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79c76ba9210341538cbcf2a5e0ef30b1.json"}}, {"family": "Khan", "given": "M Muzzamil Yasin", "initials": "MMY"}, {"family": "Raut", "given": "Sumit", "initials": "S", "orcid": "0000-0001-6090-8027", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9d431cfd57548979e61ff7287da4551.json"}}, {"family": "Shalaby", "given": "Mahmoud Mohamed Mohamed", "initials": "MMM", "orcid": "0000-0001-7237-4616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51ae61a95e0243438b5603032c6bc49b.json"}}, {"family": "Anwar", "given": "Rana Usman", "initials": "RU", "orcid": "0000-0002-7874-3870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2be3d1deeb044679da6f7738f399087.json"}}, {"family": "Farooq", "given": "Maheen", "initials": "M", "orcid": "0000-0001-5084-8614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64e7d11516d400a91a9ee939f984b49.json"}}, {"family": "Soparia", "given": "Krupa Ketankumar", "initials": "KK", "orcid": "0000-0002-0711-5826", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae4d64ac01bc4241a25a27dd4c9dc77e.json"}}, {"family": "Ramalho", "given": "Rodrigo", "initials": "R", "orcid": "0000-0002-2372-6854", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b990d3c278047a9b3878d47316ea4ed.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-10-17", "journal": {"title": "Brain Behav", "issn": "2162-3279", "pages": "e2383", "issn-l": null}, "abstract": "Poor quality sleep and emotional disturbances are expected in times of crisis. COVID-19 has severely impacted healthcare worldwide and with that comes the concern about its effects on healthcare workers. The purpose of the present study was to assess sleep quality and psychological distress in healthcare workers during the COVID-19 pandemic.\n\nThe present work is a multi-centric cross-sectional study targeting healthcare workers from India, Pakistan, and Nepal. It used an online version of the Pittsburg Sleep Quality Index and the General Health Questionnaire, and data were analyzed using SPSS V.24.\n\nA total of 1790 participants completed the questionnaire. Of the 1790 participants, 57% reported poor sleep quality, and 10% reported a high level of psychological distress. A cross-cultural comparison found some differences between the different groups of participants. The details of the differences were further explored in the article.\n\nThe present study highlights that a significant proportion of healthcare workers are affected by poor sleep quality and psychological distress during the COVID-19 pandemic. It also emphasizes the imperative to provide them with psychosocial support to avoid potential short- and long-term psychological consequences of these troubling times.", "doi": "10.1002/brb3.2383", "pmid": "34661987", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-10-21T04:58:34.375Z", "modified": "2021-10-21T04:58:34.863Z"}, {"entity": "publication", "iuid": "ea26f82200d843c39406150be734c4b7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ea26f82200d843c39406150be734c4b7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ea26f82200d843c39406150be734c4b7"}}, "title": "Robotic-Based Well-Being Monitoring and Coaching System for the Elderly in Their Daily Activities", "authors": [{"family": "Calatrava-Nicol\u00e1s", "given": "Francisco M", "initials": "FM", "orcid": "0000-0001-6647-4215", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37ad41c6253a489c809900830c616348.json"}}, {"family": "Guti\u00e9rrez-Maestro", "given": "Eduardo", "initials": "E"}, {"family": "Bautista-Salinas", "given": "Daniel", "initials": "D", "orcid": "0000-0001-5318-952X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef0d6dafcd324c9eb0cad123179d7639.json"}}, {"family": "Ortiz", "given": "Francisco J", "initials": "FJ", "orcid": "0000-0002-2294-688X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10dde443cdb44d008b36eb5d1073d549.json"}}, {"family": "Gonz\u00e1lez", "given": "Joaqu\u00edn Roca", "initials": "JR"}, {"family": "Vera-Repullo", "given": "Jos\u00e9 Alfonso", "initials": "JA"}, {"family": "Jim\u00e9nez-Buend\u00eda", "given": "Manuel", "initials": "M", "orcid": "0000-0002-6092-1974", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67e238cdac5440b7936dba299312872c.json"}}, {"family": "M\u00e9ndez", "given": "Inmaculada", "initials": "I", "orcid": "0000-0001-8458-5314", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e971819fe8a447828199a0f987619383.json"}}, {"family": "Ruiz-Esteban", "given": "Cecilia", "initials": "C", "orcid": "0000-0002-5836-331X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae5cc8fc2ffe4cf384eab19408c21624.json"}}, {"family": "Mozos", "given": "Oscar Mart\u00ednez", "initials": "OM"}], "type": "journal-article", "published": "2021-10-16", "journal": {"title": "Sensors (Basel)", "issn": "1424-8220", "issn-l": null, "volume": "21", "issue": "20", "pages": "6865"}, "abstract": null, "doi": "10.3390/s21206865", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:29:19.094Z", "modified": "2022-02-17T11:44:28.465Z"}, {"entity": "publication", "iuid": "b96c3e80cf1140bc8be296eb4d99e995", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b96c3e80cf1140bc8be296eb4d99e995.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b96c3e80cf1140bc8be296eb4d99e995"}}, "title": "Correspondence regarding \"Delay to elective colorectal cancer surgery and implications for survival: a systematic review and meta-analysis\".", "authors": [{"family": "Onerup", "given": "Aron", "initials": "A"}, {"family": "Rydbeck", "given": "Daniel", "initials": "D"}, {"family": "Bock", "given": "David", "initials": "D"}, {"family": "Haglind", "given": "Eva", "initials": "E"}, {"family": "Angenete", "given": "Eva", "initials": "E", "orcid": "0000-0001-9966-4904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/473b9940a9f34e379796200d3769cbf6.json"}}], "type": "letter", "published": "2021-10-16", "journal": {"title": "Colorectal Dis", "issn": "1463-1318", "issn-l": null}, "abstract": "We read with interest the article by Whittaker et al [1]. We believe that the research question is of importance both in light of delayed treatment during the COVID-19 pandemic and in light of recent results where preoperative lifestyle changes only seem to be effective when performed for at least six weeks [2, 3]. However, we have some questions regarding the methodology and conclusions from the study.", "doi": "10.1111/codi.15957", "pmid": "34655446", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-21T05:04:00.437Z", "modified": "2021-10-21T05:04:00.515Z"}, {"entity": "publication", "iuid": "c02bff9bce9740ffb1887af7a9a305ec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c02bff9bce9740ffb1887af7a9a305ec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c02bff9bce9740ffb1887af7a9a305ec"}}, "title": "Bacterial contamination of the smartphones of healthcare workers in a German tertiary-care hospital before and during the COVID-19 pandemic.", "authors": [{"family": "Tannh\u00e4user", "given": "Romy", "initials": "R"}, {"family": "Nickel", "given": "Olaf", "initials": "O"}, {"family": "Lindner", "given": "Margareta", "initials": "M"}, {"family": "Bethge", "given": "Angela", "initials": "A"}, {"family": "Wolf", "given": "Johannes", "initials": "J"}, {"family": "Borte", "given": "Stephan", "initials": "S"}, {"family": "L\u00fcbbert", "given": "Christoph", "initials": "C"}], "type": "journal article", "published": "2021-10-16", "journal": {"title": "Am J Infect Control", "issn": "1527-3296", "issn-l": null}, "abstract": "Assuming that hygiene measures have improved significantly due to COVID-19, we aimed to investigate bacterial colonization on smartphones (SPs) owned by healthcare workers (HCWs) before and during the pandemic.\n\nEmploying a before-and-after study design, randomly selected HCWs were included. Devices underwent sampling under real-life conditions, without prior manipulation. Swabs were collected in 2012 (pre-pandemic) and 2021 to determine microbial colonization. Isolates were identified by MALDI-TOF mass spectrometry and underwent microbiological susceptibility testing.\n\nThe final analysis included 295 HCWs (67% female, mean age 34 years) from 26 wards. Bacterial contamination was present on 293 of 295 SP screens (99.3%). The proportion of clinically relevant bacterial pathogens (e.g. Staphylococcus aureus, enterococci, Enterobacterales, non-fermenting bacteria) ranged from 21.2% in 2012 to 39.8% in 2021. Resistance profiles revealed a proportion of multidrug-resistant bacteria such as MRSA and VRE of less than 2%. The comparison of before-and-after sampling showed a significant increase in smartphone use during work from 2012 to 2021 with a simultaneous increase in cleaning intensity, probably as a result of the COVID-19 pandemic.\n\nBacterial contamination of SPs within the hospital is of concern and can serve as a source of cross-contamination. Hence, SPs must be carefully disinfected after handling in healthcare. Behavioral changes related to the COVID-19 pandemic could have a significant impact if implemented sustainably in everyday clinical practice.", "doi": "10.1016/j.ajic.2021.09.025", "pmid": "34666129", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0196-6553(21)00669-6"}], "notes": [], "created": "2021-10-21T04:50:10.433Z", "modified": "2021-10-21T04:50:10.470Z"}, {"entity": "publication", "iuid": "fda0d68c9682442b9ea60df82cad31e6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fda0d68c9682442b9ea60df82cad31e6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fda0d68c9682442b9ea60df82cad31e6"}}, "title": "Self-reported impact of the COVID-19 pandemic, affective responding, and subjective well-being: A Swedish survey.", "authors": [{"family": "Gr\u00f6ndal", "given": "Maria", "initials": "M", "orcid": "0000-0002-1108-249X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/710a6d6cf4de46eb9ae1b2e4837dc67c.json"}}, {"family": "Ask", "given": "Karl", "initials": "K", "orcid": "0000-0001-5093-5902", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec311e51b22d445f98839bf046ab4637.json"}}, {"family": "Luke", "given": "Timothy J", "initials": "TJ", "orcid": "0000-0002-5513-6605", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d790d0984ed42b6afa6f8649e74e836.json"}}, {"family": "Winblad", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2021-10-15", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0258778", "issn-l": "1932-6203"}, "abstract": "A rapid stream of research confirms that the COVID-19 pandemic is a global threat to mental health and psychological well-being. It is therefore important to identify both hazardous and protective individual factors during the pandemic. The current research explored the relationships between self-reported affective responding, perceived personal consequences of the COVID-19 pandemic, and subjective well-being. An online survey (N = 471) conducted in Sweden between June and September, 2020, showed that higher levels of irritability, impulsivity, and the tendency to experience and express anger were generally associated with more severe personal consequences of the pandemic, particularly in areas related to family life, work/study, and finances. While more severe impacts of the pandemic in these areas of life were directly associated with lower subjective well-being, emotion regulation through cognitive reappraisal appeared to moderate the extent to which consequences of the pandemic in other areas of life (i.e., social, free-time and physical activities) translated into decreased well-being. This suggests that cognitive reappraisal may serve to protect against some of the debilitating effects of the COVID-19 pandemic on mental health. Overall, the results indicate that the perceived consequences of the pandemic are multifaceted and that future research should examine these consequences using a multidimensional approach.", "doi": "10.1371/journal.pone.0258778", "pmid": "34653222", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-05122"}], "notes": [], "created": "2021-10-21T05:04:57.088Z", "modified": "2021-10-21T05:04:57.216Z"}, {"entity": "publication", "iuid": "16f513d95162469b87c66881775a8960", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16f513d95162469b87c66881775a8960.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16f513d95162469b87c66881775a8960"}}, "title": "Results of the COVID-19 mental health international for the general population (COMET-G) study.", "authors": [{"family": "Fountoulakis", "given": "Konstantinos N", "initials": "KN"}, {"family": "Karakatsoulis", "given": "Grigorios", "initials": "G"}, {"family": "Abraham", "given": "Seri", "initials": "S"}, {"family": "Adorjan", "given": "Kristina", "initials": "K"}, {"family": "Ahmed", "given": "Helal Uddin", "initials": "HU"}, {"family": "Alarc\u00f3n", "given": "Renato D", "initials": "RD"}, {"family": "Arai", "given": "Kiyomi", "initials": "K"}, {"family": "Auwal", "given": "Sani Salihu", "initials": "SS"}, {"family": "Berk", "given": "Michael", "initials": "M"}, {"family": "Bjedov", "given": "Sarah", "initials": "S"}, {"family": "Bobes", "given": "Julio", "initials": "J"}, {"family": "Bobes-Bascaran", "given": "Teresa", "initials": "T"}, {"family": "Bourgin-Duchesnay", "given": "Julie", "initials": "J"}, {"family": "Bredicean", "given": "Cristina Ana", "initials": "CA"}, {"family": "Bukelskis", "given": "Laurynas", "initials": "L"}, {"family": "Burkadze", "given": "Akaki", "initials": "A"}, {"family": "Abud", "given": "Indira Indiana Cabrera", "initials": "IIC"}, {"family": "Castilla-Puentes", "given": "Ruby", "initials": "R"}, {"family": "Cetkovich", "given": "Marcelo", "initials": "M"}, {"family": "Colon-Rivera", "given": "Hector", "initials": "H"}, {"family": "Corral", "given": "Ricardo", "initials": "R"}, {"family": "Cortez-Vergara", "given": "Carla", "initials": "C"}, {"family": "Crepin", "given": "Piirika", "initials": "P"}, {"family": "De Berardis", "given": "Domenico", "initials": "D"}, {"family": "Zamora Delgado", "given": "Sergio", "initials": "S"}, {"family": "De Lucena", "given": "David", "initials": "D"}, {"family": "De Sousa", "given": "Avinash", "initials": "A"}, {"family": "Stefano", "given": "Ramona Di", "initials": "RD"}, {"family": "Dodd", "given": "Seetal", "initials": "S"}, {"family": "Elek", "given": "Livia Priyanka", "initials": "LP"}, {"family": "Elissa", "given": "Anna", "initials": "A"}, {"family": "Erdelyi-Hamza", "given": "Berta", "initials": "B"}, {"family": "Erzin", "given": "Gamze", "initials": "G"}, {"family": "Etchevers", "given": "Martin J", "initials": "MJ"}, {"family": "Falkai", "given": "Peter", "initials": "P"}, {"family": "Farcas", "given": "Adriana", "initials": "A"}, {"family": "Fedotov", "given": "Ilya", "initials": "I"}, {"family": "Filatova", "given": "Viktoriia", "initials": "V"}, {"family": "Fountoulakis", "given": "Nikolaos K", "initials": "NK"}, {"family": "Frankova", "given": "Iryna", "initials": "I"}, {"family": "Franza", "given": "Francesco", "initials": "F"}, {"family": "Frias", "given": "Pedro", "initials": "P"}, {"family": "Galako", "given": "Tatiana", "initials": "T"}, {"family": "Garay", "given": "Cristian J", "initials": "CJ"}, {"family": "Garcia-\u00c1lvarez", "given": "Leticia", "initials": "L"}, {"family": "Garc\u00eda-Portilla", "given": "Maria Paz", "initials": "MP"}, {"family": "Gonda", "given": "Xenia", "initials": "X"}, {"family": "Gondek", "given": "Tomasz M", "initials": "TM"}, {"family": "Gonz\u00e1lez", "given": "Daniela Morera", "initials": "DM"}, {"family": "Gould", "given": "Hilary", "initials": "H"}, {"family": "Grandinetti", "given": "Paolo", "initials": "P"}, {"family": "Grau", "given": "Arturo", "initials": "A"}, {"family": "Groudeva", "given": "Violeta", "initials": "V"}, {"family": "Hagin", "given": "Michal", "initials": "M"}, {"family": "Harada", "given": "Takayuki", "initials": "T"}, {"family": "Hasan", "given": "Tasdik M", "initials": "TM"}, {"family": "Hashim", "given": "Nurul Azreen", "initials": "NA"}, {"family": "Hilbig", "given": "Jan", "initials": "J"}, {"family": "Hossain", "given": "Sahadat", "initials": "S"}, {"family": "Iakimova", "given": "Rossitza", "initials": "R"}, {"family": "Ibrahim", "given": "Mona", "initials": "M"}, {"family": "Iftene", "given": "Felicia", "initials": "F"}, {"family": "Ignatenko", "given": "Yulia", "initials": "Y"}, {"family": "Irarrazaval", "given": "Matias", "initials": "M"}, {"family": "Ismail", "given": "Zaliha", "initials": "Z"}, {"family": "Ismayilova", "given": "Jamila", "initials": "J"}, {"family": "Jakobs", "given": "Asaf", "initials": "A"}, {"family": "Jakovljevi\u0107", "given": "Miro", "initials": "M"}, {"family": "Jak\u0161i\u0107", "given": "Nenad", "initials": "N"}, {"family": "Javed", "given": "Afzal", "initials": "A"}, {"family": "Kafali", "given": "Helin Yilmaz", "initials": "HY"}, {"family": "Karia", "given": "Sagar", "initials": "S"}, {"family": "Kazakova", "given": "Olga", "initials": "O"}, {"family": "Khalifa", "given": "Doaa", "initials": "D"}, {"family": "Khaustova", "given": "Olena", "initials": "O"}, {"family": "Koh", "given": "Steve", "initials": "S"}, {"family": "Kopishinskaia", "given": "Svetlana", "initials": "S"}, {"family": "Kosenko", "given": "Korneliia", "initials": "K"}, {"family": "Koupidis", "given": "Sotirios A", "initials": "SA"}, {"family": "Kovacs", "given": "Illes", "initials": "I"}, {"family": "Kulig", "given": "Barbara", "initials": "B"}, {"family": "Lalljee", "given": "Alisha", "initials": "A"}, {"family": "Liewig", "given": "Justine", "initials": "J"}, {"family": "Majid", "given": "Abdul", "initials": "A"}, {"family": "Malashonkova", "given": "Evgeniia", "initials": "E"}, {"family": "Malik", "given": "Khamelia", "initials": "K"}, {"family": "Malik", "given": "Najma Iqbal", "initials": "NI"}, {"family": "Mammadzada", "given": "Gulay", "initials": "G"}, {"family": "Mandalia", "given": "Bilvesh", "initials": "B"}, {"family": "Marazziti", "given": "Donatella", "initials": "D"}, {"family": "Mar\u010dinko", "given": "Darko", "initials": "D"}, {"family": "Martinez", "given": "Stephanie", "initials": "S"}, {"family": "Matiekus", "given": "Eimantas", "initials": "E"}, {"family": "Mejia", "given": "Gabriela", "initials": "G"}, {"family": "Memon", "given": "Roha Saeed", "initials": "RS"}, {"family": "Mart\u00ednez", "given": "Xarah Elenne Meza", "initials": "XEM"}, {"family": "Mickevi\u010di\u016bt\u0117", "given": "Dalia", "initials": "D"}, {"family": "Milev", "given": "Roumen", "initials": "R"}, {"family": "Mohammed", "given": "Muftau", "initials": "M"}, {"family": "Molina-L\u00f3pez", "given": "Alejandro", "initials": "A"}, {"family": "Morozov", "given": "Petr", "initials": "P"}, {"family": "Muhammad", "given": "Nuru Suleiman", "initials": "NS"}, {"family": "Musta\u010d", "given": "Filip", "initials": "F"}, {"family": "Naor", "given": "Mika S", "initials": "MS"}, {"family": "Nassieb", "given": "Amira", "initials": "A"}, {"family": "Navickas", "given": "Alvydas", "initials": "A"}, {"family": "Okasha", "given": "Tarek", "initials": "T"}, {"family": "Pandova", "given": "Milena", "initials": "M"}, {"family": "Panfil", "given": "Anca-Livia", "initials": "AL"}, {"family": "Panteleeva", "given": "Liliya", "initials": "L"}, {"family": "Papava", "given": "Ion", "initials": "I"}, {"family": "Patsali", "given": "Mikaella E", "initials": "ME"}, {"family": "Pavlichenko", "given": "Alexey", "initials": "A"}, {"family": "Pejuskovic", "given": "Bojana", "initials": "B"}, {"family": "Pinto Da Costa", "given": "Mariana", "initials": "M"}, {"family": "Popkov", "given": "Mikhail", "initials": "M"}, {"family": "Popovic", "given": "Dina", "initials": "D"}, {"family": "Raduan", "given": "Nor Jannah Nasution", "initials": "NJN"}, {"family": "Ram\u00edrez", "given": "Francisca Vargas", "initials": "FV"}, {"family": "Rancans", "given": "Elmars", "initials": "E"}, {"family": "Razali", "given": "Salmi", "initials": "S"}, {"family": "Rebok", "given": "Federico", "initials": "F"}, {"family": "Rewekant", "given": "Anna", "initials": "A"}, {"family": "Flores", "given": "Elena Ninoska Reyes", "initials": "ENR"}, {"family": "Rivera-Encinas", "given": "Mar\u00eda Teresa", "initials": "MT"}, {"family": "Saiz", "given": "Pilar", "initials": "P"}, {"family": "de Carmona", "given": "Manuel S\u00e1nchez", "initials": "MS"}, {"family": "Mart\u00ednez", "given": "David Saucedo", "initials": "DS"}, {"family": "Saw", "given": "Jo Anne", "initials": "JA"}, {"family": "Saygili", "given": "G\u00f6rkem", "initials": "G"}, {"family": "Schneidereit", "given": "Patricia", "initials": "P"}, {"family": "Shah", "given": "Bhumika", "initials": "B"}, {"family": "Shirasaka", "given": "Tomohiro", "initials": "T"}, {"family": "Silagadze", "given": "Ketevan", "initials": "K"}, {"family": "Sitanggang", "given": "Satti", "initials": "S"}, {"family": "Skugarevsky", "given": "Oleg", "initials": "O"}, {"family": "Spikina", "given": "Anna", "initials": "A"}, {"family": "Mahalingappa", "given": "Sridevi Sira", "initials": "SS"}, {"family": "Stoyanova", "given": "Maria", "initials": "M"}, {"family": "Szczegielniak", "given": "Anna", "initials": "A"}, {"family": "Tamasan", "given": "Simona Claudia", "initials": "SC"}, {"family": "Tavormina", "given": "Giuseppe", "initials": "G"}, {"family": "Tavormina", "given": "Maurilio Giuseppe Maria", "initials": "MGM"}, {"family": "Theodorakis", "given": "Pavlos N", "initials": "PN"}, {"family": "Tohen", "given": "Mauricio", "initials": "M"}, {"family": "Tsapakis", "given": "Eva Maria", "initials": "EM"}, {"family": "Tukhvatullina", "given": "Dina", "initials": "D"}, {"family": "Ullah", "given": "Irfan", "initials": "I"}, {"family": "Vaidya", "given": "Ratnaraj", "initials": "R"}, {"family": "Vega-Dienstmaier", "given": "Johann M", "initials": "JM"}, {"family": "Vrublevska", "given": "Jelena", "initials": "J"}, {"family": "Vukovic", "given": "Olivera", "initials": "O"}, {"family": "Vysotska", "given": "Olga", "initials": "O"}, {"family": "Widiasih", "given": "Natalia", "initials": "N"}, {"family": "Yashikhina", "given": "Anna", "initials": "A"}, {"family": "Prezerakos", "given": "Panagiotis E", "initials": "PE"}, {"family": "Smirnova", "given": "Daria", "initials": "D"}], "type": "journal article", "published": "2021-10-15", "journal": {"title": "Eur Neuropsychopharmacol", "issn": "1873-7862", "volume": "54", "pages": "21-40", "issn-l": null}, "abstract": "There are few published empirical data on the effects of COVID-19 on mental health, and until now, there is no large international study.\n\nDuring the COVID-19 pandemic, an online questionnaire gathered data from 55,589 participants from 40 countries (64.85% females aged 35.80 \u00b1 13.61; 34.05% males aged 34.90\u00b113.29 and 1.10% other aged 31.64\u00b113.15). Distress and probable depression were identified with the use of a previously developed cut-off and algorithm respectively.\n\nDescriptive statistics were calculated. Chi-square tests, multiple forward stepwise linear regression analyses and Factorial Analysis of Variance (ANOVA) tested relations among variables.\n\nProbable depression was detected in 17.80% and distress in 16.71%. A significant percentage reported a deterioration in mental state, family dynamics and everyday lifestyle. Persons with a history of mental disorders had higher rates of current depression (31.82% vs. 13.07%). At least half of participants were accepting (at least to a moderate degree) a non-bizarre conspiracy. The highest Relative Risk (RR) to develop depression was associated with history of Bipolar disorder and self-harm/attempts (RR = 5.88). Suicidality was not increased in persons without a history of any mental disorder. Based on these results a model was developed.\n\nThe final model revealed multiple vulnerabilities and an interplay leading from simple anxiety to probable depression and suicidality through distress. This could be of practical utility since many of these factors are modifiable. Future research and interventions should specifically focus on them.", "doi": "10.1016/j.euroneuro.2021.10.004", "pmid": "34758422", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0924-977X(21)00775-6"}, {"db": "pmc", "key": "PMC8609892"}], "notes": [], "created": "2021-11-26T15:22:18.414Z", "modified": "2021-11-26T15:22:18.427Z"}, {"entity": "publication", "iuid": "a8685649f67047399e5093949f457284", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8685649f67047399e5093949f457284.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8685649f67047399e5093949f457284"}}, "title": "Psychometric Testing of the Modified Dental Anxiety Scale among Iranian Adolescents during COVID-19 Pandemic", "authors": [{"family": "Lin", "given": "Chung Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": 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"https://publications-covid19.scilifelab.se/researcher/301b59d7b5074ace866319c0210d60ac.json"}}, {"family": "Tascini", "given": "Carlo", "initials": "C", "orcid": "0000-0001-9625-6024", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea9384b56c654e5ebec3000ee2c4e285.json"}}, {"family": "Miranda-Castillo", "given": "Carolina", "initials": "C", "orcid": "0000-0001-8763-9576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8152e4ccbe9146ab96382e954909b55d.json"}}, {"family": "Khanna", "given": "Nina", "initials": "N", "orcid": "0000-0002-2642-419X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4ea8c9224c44ead9bcf5360e0412cd4.json"}}, {"family": "M\u00e9ndez", "given": "Gustavo-Adolfo", "initials": "GA", "orcid": "0000-0003-0514-7004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed5e3f5f20fd4a40b5780d14663ac211.json"}}, {"family": "Petzer", "given": "Verena", "initials": "V", "orcid": "0000-0002-9205-1440", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b52c652fbe2245d1a3df0ca220d8ad98.json"}}, {"family": "Nov\u00e1k", "given": "Jan", "initials": "J"}, {"family": "Besson", "given": "Caroline", "initials": "C", "orcid": "0000-0003-4364-7173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adc322a60efe4963a3ff76aa00c885d6.json"}}, {"family": "Dul\u00e9ry", "given": "R\u00e9my", "initials": "R", "orcid": "0000-0002-5024-1713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e911a2d994434edbb736f77b7ccfcd72.json"}}, {"family": "Lamure", "given": "Sylvain", "initials": "S", "orcid": "0000-0001-5980-305X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0dc734a9a9e4016b2a1699809823fe2.json"}}, {"family": "Nucci", "given": "Marcio", "initials": "M", "orcid": "0000-0003-4867-0014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/abfb43328b9e49f5bb8a68af1dea23a9.json"}}, {"family": "Zambrotta", "given": "Giovanni", "initials": "G", "orcid": "0000-0002-8612-2994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa7e3e475561489d8a588f32256d8789.json"}}, {"family": "\u017d\u00e1k", "given": "Pavel", "initials": "P", "orcid": "0000-0003-4465-5343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/575505da6a594afd909f7d23ee161067.json"}}, {"family": "Seval", "given": "Guldane Cengiz", "initials": "GC", "orcid": "0000-0001-9433-2054", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e3b8c93389cf44fbabefe0d826d98f90.json"}}, {"family": "Bonuomo", "given": "Valentina", "initials": "V", "orcid": "0000-0001-6491-8337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/71cfcc19d793475898e9a4e94d9ba5ba.json"}}, {"family": "Mayer", "given": "Ji\u0159\u00ed", "initials": "J", "orcid": "0000-0003-0567-9887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af07e6256c3c4aa086315372fdbbc25c.json"}}, {"family": "L\u00f3pez-Garc\u00eda", "given": "Alberto", "initials": "A", "orcid": "0000-0002-5354-5261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c785356a67e4cbb9835fe9ce04a6153.json"}}, {"family": "Sacchi", "given": "Maria Vittoria", "initials": "MV", "orcid": "0000-0001-8133-3357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62e9765439304851b3d996f5a4ce6603.json"}}, {"family": "Booth", "given": "Stephen", "initials": "S", "orcid": "0000-0003-2687-0234", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d01b042ad524b7f8f5e6ac4486c2121.json"}}, {"family": "Ciceri", "given": "Fabio", "initials": "F", "orcid": "0000-0003-0873-0123", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/409a23f2dc8143a18aba6f8b91e597c7.json"}}, {"family": "Oberti", "given": "Margherita", "initials": "M"}, {"family": "Salvini", "given": "Marco", "initials": "M"}, {"family": "Izuzquiza", "given": "Macarena", "initials": "M"}, {"family": "Nunes-Rodrigues", "given": "Raquel", "initials": "R", "orcid": "0000-0002-8347-4281", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59fe3851cbd1404395c359435a99edbf.json"}}, {"family": "Ammatuna", "given": "Emanuele", "initials": "E", "orcid": "0000-0001-8247-4901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5904d1457399478aaaba50bcc584d502.json"}}, {"family": "Obr", "given": "Ale\u0161", "initials": "A", "orcid": "0000-0002-6758-3074", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35684b424cde4350a32f7ea16e0c9093.json"}}, {"family": "Herbrecht", "given": "Raoul", "initials": "R", "orcid": "0000-0002-9381-4876", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d015f48d57ac4543b0d5a5965582f46e.json"}}, {"family": "N\u00fa\u00f1ez-Mart\u00edn-Buitrago", "given": "Luc\u00eda", "initials": "L"}, {"family": "Mancini", "given": "Valentina", "initials": "V"}, {"family": "Shwaylia", "given": "Hawraa", "initials": "H", "orcid": "0000-0002-4098-6092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd1fea4026e941a98fa7c6f7a084bdb6.json"}}, {"family": "Scium\u00e8", "given": "Mariarita", "initials": "M", "orcid": "0000-0001-7958-4966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f9857d37d7041a3ae43ee186a3d0629.json"}}, {"family": "Essame", "given": "Jenna", "initials": "J", "orcid": "0000-0003-0926-5577", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e742441946aa4011877daa743e29be52.json"}}, {"family": "Nygaard", "given": "Marietta", "initials": "M"}, {"family": "Batini\u0107", "given": "Josip", "initials": "J", "orcid": "0000-0001-5595-9911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d11d10189d71468e9e606ab7b428327c.json"}}, {"family": "Gonzaga", "given": "Yung", "initials": "Y", "orcid": "0000-0003-1416-2118", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ff6be47e1ad4b729cdc6d4648073464.json"}}, {"family": "Regalado-Artamendi", "given": "Isabel", "initials": "I", "orcid": "0000-0002-9673-9015", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4527d7987ea449ff9a3d6e3135c54018.json"}}, {"family": "Karlsson", "given": "Linda Katharina", "initials": "LK", "orcid": "0000-0003-3317-7550", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7755dec3898c4e33a5729825a8d2dacd.json"}}, {"family": "Shapetska", "given": "Maryia", "initials": "M", "orcid": "0000-0002-1223-9161", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87e2b1bfa19d48d5892330aa3114c9ba.json"}}, {"family": "Hanakova", "given": "Michaela", "initials": "M"}, {"family": "El-Ashwah", "given": "Shaimaa", "initials": "S", "orcid": "0000-0003-2210-1534", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46dc0125ae354da09dddd0ffd083d199.json"}}, {"family": "Borb\u00e9nyi", "given": "Zita", "initials": "Z"}, {"family": "\u00c7olak", "given": "G\u00f6k\u00e7e Melis", "initials": "GM", "orcid": "0000-0002-7662-7454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42d2006ada9e473db89249bc882d6083.json"}}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Dragonetti", "given": "Giulia", "initials": "G", "orcid": "0000-0003-1775-6333", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81694822ac4d4074bfabe757d03f5f9e.json"}}, {"family": "Maraglino", "given": "Alessio Maria Edoardo", "initials": "AME"}, {"family": "Rinaldi", "given": "Amelia", "initials": "A", "orcid": "0000-0002-8211-5076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/689f30c83b4e4da7a48d853abd22d6e5.json"}}, {"family": "De Ram\u00f3n-S\u00e1nchez", "given": "Cristina", "initials": "C", "orcid": "0000-0002-8167-6410", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d42267ab742491d95080c6592197d6a.json"}}, {"family": "Cornely", "given": "Oliver A", "initials": "OA", "orcid": "0000-0001-9599-3137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3c62d8346924e69b6c99e4007c3831c.json"}}, {"family": "EPICOVIDEHA working group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-10-14", "journal": {"title": "J Hematol Oncol", "issn": "1756-8722", "volume": "14", "issue": "1", "pages": "168", "issn-l": null}, "abstract": "Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics of HM patients developing COVID-19 and analyzed predictors of mortality.\n\nThe survey was supported by the Scientific Working Group Infection in Hematology of the European Hematology Association (EHA). Eligible for the analysis were adult patients with HM and laboratory-confirmed COVID-19 observed between March and December 2020.\n\nThe study sample includes 3801 cases, represented by lymphoproliferative (mainly non-Hodgkin lymphoma n = 1084, myeloma n = 684 and chronic lymphoid leukemia n = 474) and myeloproliferative malignancies (mainly acute myeloid leukemia n = 497 and myelodysplastic syndromes n = 279). Severe/critical COVID-19 was observed in 63.8% of patients (n = 2425). Overall, 2778 (73.1%) of the patients were hospitalized, 689 (18.1%) of whom were admitted to intensive care units (ICUs). Overall, 1185 patients (31.2%) died. The primary cause of death was COVID-19 in 688 patients (58.1%), HM in 173 patients (14.6%), and a combination of both COVID-19 and progressing HM in 155 patients (13.1%). Highest mortality was observed in acute myeloid leukemia (199/497, 40%) and myelodysplastic syndromes (118/279, 42.3%). The mortality rate significantly decreased between the first COVID-19 wave (March-May 2020) and the second wave (October-December 2020) (581/1427, 40.7% vs. 439/1773, 24.8%, p value < 0.0001). In the multivariable analysis, age, active malignancy, chronic cardiac disease, liver disease, renal impairment, smoking history, and ICU stay correlated with mortality. Acute myeloid leukemia was a higher mortality risk than lymphoproliferative diseases.\n\nThis survey confirms that COVID-19 patients with HM are at high risk of lethal complications. However, improved COVID-19 prevention has reduced mortality despite an increase in the number of reported cases.", "doi": "10.1186/s13045-021-01177-0", "pmid": "34649563", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13045-021-01177-0"}], "notes": [], "created": "2021-10-21T05:05:31.090Z", "modified": "2021-10-21T05:05:33.687Z"}, {"entity": "publication", "iuid": "63244c74094741c59119d7f7977b6905", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63244c74094741c59119d7f7977b6905.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63244c74094741c59119d7f7977b6905"}}, "title": "A Spatial Analysis of COVID-19 in African Countries: Evaluating the Effects of Socio-Economic Vulnerabilities and Neighbouring.", "authors": [{"family": "Manda", "given": "Samuel O M", "initials": "SOM", "orcid": "0000-0002-9672-3312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b073c7d0b3d40e5acc15d6be304fd24.json"}}, {"family": "Darikwa", "given": "Timotheus", "initials": "T", "orcid": "0000-0002-6555-3154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e75f35ad6d94666a549b45c65f038ca.json"}}, {"family": "Nkwenika", "given": "Tshifhiwa", "initials": "T"}, {"family": "Bergquist", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2021-10-14", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "20", "issn-l": null}, "abstract": "The ongoing highly contagious coronavirus disease 2019 (COVID-19) pandemic, which started in Wuhan, China, in December 2019, has now become a global public health problem. Using publicly available data from the COVID-19 data repository of Our World in Data, we aimed to investigate the influences of spatial socio-economic vulnerabilities and neighbourliness on the COVID-19 burden in African countries. We analyzed the first wave (January-September 2020) and second wave (October 2020 to May 2021) of the COVID-19 pandemic using spatial statistics regression models. As of 31 May 2021, there was a total of 4,748,948 confirmed COVID-19 cases, with an average, median, and range per country of 101,041, 26,963, and 2191 to 1,665,617, respectively. We found that COVID-19 prevalence in an Africa country was highly dependent on those of neighbouring Africa countries as well as its economic wealth, transparency, and proportion of the population aged 65 or older (p-value < 0.05). Our finding regarding the high COVID-19 burden in countries with better transparency and higher economic wealth is surprising and counterintuitive. We believe this is a reflection on the differences in COVID-19 testing capacity, which is mostly higher in more developed countries, or data modification by less transparent governments. Country-wide integrated COVID suppression strategies such as limiting human mobility from more urbanized to less urbanized countries, as well as an understanding of a county's social-economic characteristics, could prepare a country to promptly and effectively respond to future outbreaks of highly contagious viral infections such as COVID-19.", "doi": "10.3390/ijerph182010783", "pmid": "34682528", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph182010783"}], "notes": [], "created": "2021-10-26T18:15:49.424Z", "modified": "2021-10-26T18:15:49.522Z"}, {"entity": "publication", "iuid": "872d89e3d1164efeb1fb997c306b26c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/872d89e3d1164efeb1fb997c306b26c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/872d89e3d1164efeb1fb997c306b26c0"}}, "title": "A Longitudinal Study of Gambling Behaviors During the COVID-19 Pandemic in Sweden.", "authors": [{"family": "M\u00e5nsson", "given": "Viktor", "initials": "V"}, {"family": "Wall", "given": "H\u00e5kan", "initials": "H"}, {"family": "Berman", "given": "Anne H", "initials": "AH"}, {"family": "Jayaram-Lindstr\u00f6m", "given": "Nitya", "initials": "N"}, {"family": "Rosendahl", "given": "Ingvar", "initials": "I"}], "type": "journal article", "published": "2021-10-14", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "708037", "issn-l": "1664-1078"}, "abstract": "This study aimed to investigate changes in gambling behaviors during the first and second waves of the COVID-19 pandemic in Sweden. Participants who had gambled within the past year were recruited from social media and the Swedish National Helpline (n = 325, mean age 39.8 years, 64.8% males, 31.3% with problem gambling) and completed an online survey measuring gambling behaviors, consequences of the pandemic in general and worries related to the pandemic. A sub-sample (n = 139) completed a follow-up survey, during the second wave. The results showed no significant associations between COVID-19 consequences (financial or increased isolation) and increased monthly gambling behavior. No major migrations were observed between game types. However, gambling on a high-risk game (OR = 7.44, p < 0.001) and worrying about mental health due to the pandemic (OR = 2.85, p < 0.001) were significantly associated with past year gambling problems and increased monthly gambling problems from the first to the second wave. More longitudinal research is needed in vulnerable populations, to fully understand the long-term consequences of the pandemic.", "doi": "10.3389/fpsyg.2021.708037", "pmid": "34721154", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8552012"}], "notes": [], "created": "2021-11-02T15:31:07.371Z", "modified": "2023-06-19T14:25:06.196Z"}, {"entity": "publication", "iuid": "59a5b39a1bad4ee2b05041ad5334f949", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/59a5b39a1bad4ee2b05041ad5334f949.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/59a5b39a1bad4ee2b05041ad5334f949"}}, "title": "The effects of a physical and cognitive training intervention vs. physical training alone on older adults' physical activity: A randomized controlled trial with extended follow-up during COVID-19.", "authors": [{"family": "Savikangas", "given": "Tiina", "initials": "T", "orcid": "0000-0002-8367-4304", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00e78fc921a64887bbb3accdba9da9fc.json"}}, {"family": "T\u00f6rm\u00e4kangas", "given": "Timo", "initials": "T"}, {"family": "Tirkkonen", "given": "Anna", "initials": "A"}, {"family": "Alen", "given": "Markku", "initials": "M"}, {"family": "Fielding", "given": "Roger A", "initials": "RA"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Rantalainen", "given": "Timo", "initials": "T"}, {"family": "Stigsdotter Neely", "given": "Anna", "initials": "A"}, {"family": "Sipil\u00e4", "given": "Sarianna", "initials": "S"}], "type": "journal article", "published": "2021-10-13", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0258559", "issn-l": "1932-6203"}, "abstract": "Executive functions underlie self-regulation and are thus important for physical activity and adaptation to new situations. The aim was to investigate, if yearlong physical and cognitive training (PTCT) had greater effects on physical activity among older adults than physical training (PT) alone, and if executive functions predicted physical activity at baseline, after six (6m) and twelve months (12m) of the interventions, one-year post-intervention follow-up and an extended follow-up during COVID-19 lockdown.\n\nData from a single-blinded, parallel-group randomized controlled trial (PASSWORD-study, ISRCTN52388040) were utilized. Participants were 70-85 years old community-dwelling men and women from Jyv\u00e4skyl\u00e4, Finland. PT (n = 159) included supervised resistance, walking and balance training, home-exercises and self-administered moderate activity. PTCT (n = 155) included PT and cognitive training targeting executive functions on a computer program. Physical activity was assessed with a one-item, seven-scale question. Executive functions were assessed with color-word Stroop, Trail Making Test (TMT) B-A and Letter Fluency. Changes in physical activity were modeled with multinomial logistic models and the impact of executive functions on physical activity with latent change score models.\n\nNo significant group-by-time interaction was observed for physical activity (p>0.1). The subjects were likely to select an activity category higher than baseline throughout the study (pooled data: B = 0.720-1.614, p<0.001-0.046). Higher baseline Stroop predicted higher physical activity through all subsequent time-points (pooled data: B = 0.011-0.013, p = 0.015-0.030). Higher baseline TMT B-A predicted higher physical activity at 6m (pooled data: B = 0.007, p = 0.006) and during COVID-19 (B = 0.005, p = 0.030). In the PT group, higher baseline Letter Fluency predicted higher physical activity at 12m (B = -0.028, p = 0.030) and follow-up (B = -0.042, p = 0.002).\n\nCognitive training did not have additive effects over physical training alone on physical activity, but multicomponent training and higher executive function at baseline may support adaptation to and maintenance of a physically active lifestyle among older adults.", "doi": "10.1371/journal.pone.0258559", "pmid": "34644357", "labels": {"Category: Proteins": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-19624"}, {"db": "pmc", "key": "PMC8513828"}], "notes": [], "created": "2021-10-21T05:07:40.043Z", "modified": "2021-10-21T05:07:40.098Z"}, {"entity": "publication", "iuid": "d70904b2b74441ef99cf0b79c91e8245", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d70904b2b74441ef99cf0b79c91e8245.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d70904b2b74441ef99cf0b79c91e8245"}}, "title": "SARS\u2013CoV\u20132 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro", "authors": [{"family": "Jiang", "given": "Hui", "initials": "H"}, {"family": "Mei", "given": "Ya Fang", "initials": "YF"}], "type": "journal-article", "published": "2021-10-13", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "10", "pages": "2056", "issn-l": "1999-4915"}, "abstract": null, "doi": "10.3390/v13102056", "pmid": null, "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:30:44.079Z", "modified": "2021-10-26T18:30:56.036Z"}, {"entity": "publication", "iuid": "1fd3d388b8404b7f82e9e5d7bffc160b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1fd3d388b8404b7f82e9e5d7bffc160b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1fd3d388b8404b7f82e9e5d7bffc160b"}}, "title": "Impact of obesity on intensive care outcomes in patients with COVID-19 in Sweden-A cohort study.", "authors": [{"family": "Sj\u00f6gren", "given": "Lovisa", "initials": "L", "orcid": "0000-0002-3425-0900", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e6cd7d544c04167bfb5cd8e7c7dc09f.json"}}, {"family": "Stenberg", "given": "Erik", "initials": "E", "orcid": "0000-0001-9189-0093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d991f094120449a7afaea3d92ade6db9.json"}}, {"family": "Thuccani", "given": "Meena", "initials": "M", "orcid": "0000-0003-2505-5596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/051393fe34b1472a83912bcf7b68713f.json"}}, {"family": "Martikainen", "given": "Jari", "initials": "J"}, {"family": "Rylander", "given": "Christian", "initials": "C", "orcid": "0000-0002-4534-7150", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/547f0c635e8144068a5dde0809547036.json"}}, {"family": "Wallenius", "given": "Ville", "initials": "V"}, {"family": "Olbers", "given": "Torsten", "initials": "T"}, {"family": "Kindblom", "given": "Jenny M", "initials": "JM", "orcid": "0000-0001-8437-0639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b24d2c900a84492a6e2974e5cf43751.json"}}], "type": "journal article", "published": "2021-10-13", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0257891", "issn-l": "1932-6203"}, "abstract": "Previous studies have shown that a high body mass index (BMI) is a risk factor for severe COVID-19. The aim of the present study was to assess whether a high BMI affects the risk of death or prolonged length of stay (LOS) in patients with COVID-19 during intensive care in Sweden.\n\nIn this observational, register-based study, we included patients with COVID-19 from the Swedish Intensive Care Registry admitted to intensive care units (ICUs) in Sweden. Outcomes assessed were death during intensive care and ICU LOS \u226514 days. We used logistic regression models to evaluate the association (odds ratio [OR] and 95% confidence interval [CI]) between BMI and the outcomes. Valid weight and height information could be retrieved in 1,649 patients (1,227 (74.4%) males) with COVID-19. We found a significant association between BMI and the risk of the composite outcome death or LOS \u226514 days in survivors (OR per standard deviation [SD] increase 1.30, 95%CI 1.16-1.44, adjusted for sex, age and comorbidities), and this association remained after further adjustment for severity of illness (simplified acute physiology score; SAPS3) at ICU admission (OR 1.30 per SD, 95%CI 1.17-1.45). Individuals with a BMI \u2265 35 kg/m2 had a doubled risk of the composite outcome. A high BMI was also associated with death during intensive care and a prolonged LOS in survivors assessed as separate outcomes. The main limitations were the restriction to the first wave of the pandemic, and the lack of information on socioeconomic status as well as smoking.\n\nIn this large cohort of Swedish ICU patients with COVID-19, a high BMI was associated with increasing risk of death and prolonged length of stay in the ICU. Based on our findings, we suggest that individuals with obesity should be more closely monitored when hospitalized for COVID-19.", "doi": "10.1371/journal.pone.0257891", "pmid": "34644316", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-22724"}, {"db": "pmc", "key": "PMC8513867"}], "notes": [], "created": "2021-10-21T05:08:00.061Z", "modified": "2021-10-21T05:08:00.267Z"}, {"entity": "publication", "iuid": "3a3e58bd90064b3889ef266c9471110b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a3e58bd90064b3889ef266c9471110b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a3e58bd90064b3889ef266c9471110b"}}, "title": "e-Learning and Web-Based Tools for Psychosocial Interventions Addressing Neuropsychiatric Symptoms of Dementia During the COVID-19 Pandemic in Tokyo, Japan: Quasi-Experimental Study.", "authors": [{"family": "Nakanishi", "given": "Miharu", "initials": "M", "orcid": "0000-0001-6200-9279", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/636f9920978f486c9148c073564a4b23.json"}}, {"family": "Yamasaki", "given": "Syudo", "initials": "S", "orcid": "0000-0002-9016-6404", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/703e839a200b4ef6b08be4c522562931.json"}}, {"family": "Endo", "given": "Kaori", "initials": "K", "orcid": "0000-0003-0854-5120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5173896a62eb481c8038090c4d1eb7a4.json"}}, {"family": "Niimura", "given": "Junko", "initials": "J", "orcid": "0000-0003-4404-055X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9765c54292f43ada4e4cb6448f9bed6.json"}}, {"family": "Ziylan", "given": "Canan", "initials": "C", "orcid": "0000-0002-7158-9508", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2af0a33c64c40a3ad69a89ac7c939fb.json"}}, {"family": "Bakker", "given": "Ton J E M", "initials": "TJEM", "orcid": "0000-0002-3773-5436", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6367f3e0f65340f5b699bcb1de688d1c.json"}}, {"family": "Granvik", "given": "Eva", "initials": "E", "orcid": "0000-0002-8862-8104", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b843c73baad49ac8c840c276621e567.json"}}, {"family": "N\u00e4gga", "given": "Katarina", "initials": "K", "orcid": "0000-0003-0194-8402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd0282d0489a4ee59dfe4f2fb4028093.json"}}, {"family": "Nishida", "given": "Atsushi", "initials": "A", "orcid": "0000-0001-6451-7699", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06cc5741754740a29041e4377f9207c3.json"}}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "JMIR Med Educ", "issn": "2369-3762", "volume": "7", "issue": "4", "pages": "e30652", "issn-l": null}, "abstract": "Concern has been raised that the COVID-19 pandemic and consequent social distancing measures may increase neuropsychiatric symptoms in people with dementia. Thus, we developed and delivered an e-learning training course to professional caregivers on using a web-based tool for psychosocial interventions for people with dementia.\n\nThe aim of our study was to evaluate the feasibility and efficacy of an e-learning course in combination with a web-based tool in addressing neuropsychiatric symptoms of dementia.\n\nA quasi-experimental design was used in Tokyo, Japan. The e-learning course was delivered three times to professional caregivers between July and December 2020. Caregivers who completed the course assessed the level of neuropsychiatric symptoms in people with dementia using the total score from the Neuropsychiatric Inventory (NPI) via a web-based tool. The primary outcome measures were the number of caregivers who implemented follow-up NPI evaluations by March 2021 and the change in NPI scores from baseline to their most recent follow-up evaluations. As a control group, information was also obtained from professional caregivers who completed a face-to-face training course using the same web-based tool between July 2019 and March 2020.\n\nA total of 268 caregivers completed the e-learning course in 2020. Of the 268 caregivers, 56 (20.9%) underwent follow-up evaluations with 63 persons with dementia. The average NPI score was significantly reduced from baseline (mean 20.4, SD 16.2) to the most recent follow-up evaluations (mean 14.3, SD 13.4). The effect size was assumed to be medium (Cohen drm [repeated measures]=0.40). The control group consisted of 252 caregivers who completed a face-to-face training course. Of the 252 caregivers, 114 (45.2%) underwent follow-up evaluations. Compared to the control group, caregivers who completed the e-learning course were significantly less likely to implement follow-up evaluations (\u03c721=52.0, P<.001). The change in NPI scores did not differ according to the type of training course (baseline-adjusted difference=-0.61, P=.69).\n\nThe replacement of face-to-face training with e-learning may have provided professionals with an opportunity to participate in the dementia behavior analysis and support enhancement (DEMBASE) program who may not have participated in the program otherwise. Although the program showed equal efficacy in terms of the two training courses, the feasibility was suboptimal with lower implementation levels for those receiving e-learning training. Thus, further strategies should be developed to improve feasibility by providing motivational triggers for implementation and technical support for care professionals. Using online communities in the program should also be investigated.", "doi": "10.2196/30652", "pmid": "34543224", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "v7i4e30652"}], "notes": [], "created": "2021-10-27T05:10:03.327Z", "modified": "2021-10-27T05:10:03.664Z"}, {"entity": "publication", "iuid": "80870541003147a987d11a033caf0d0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/80870541003147a987d11a033caf0d0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/80870541003147a987d11a033caf0d0e"}}, "title": "Susceptibility to COVID-19 after High Exposure to Perfluoroalkyl Substances from Contaminated Drinking Water: An Ecological Study from Ronneby, Sweden.", "authors": [{"family": "Nielsen", "given": "Christel", "initials": "C", "orcid": "0000-0003-3940-7847", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/383974c5a9e04eae926013a19be0fcdc.json"}}, {"family": "J\u00f6ud", "given": "Anna", "initials": "A", "orcid": "0000-0001-7192-4911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e038a5ce2f5a47bd89e7c221651a3d24.json"}}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "20", "pages": "10702", "issn-l": null}, "abstract": "There is concern that immunotoxic environmental contaminants, particularly perfluoroalkyl substances (PFAS), may play a role in the clinical course of COVID-19 and epidemiologic studies are needed to answer if high-exposed populations are especially vulnerable in light of the ongoing pandemic. The objective was, therefore, to determine if exposure to highly PFAS-contaminated drinking water was associated with an increased incidence of COVID-19 in Ronneby, Sweden, during the first year of the pandemic. We conducted an ecological study determining the sex- and age-standardized incidence ratio (SIR) in the adult population relative to a neighboring reference town with similar demographic characteristics but with only background levels of exposure. In Sweden, COVID-19 is subject to mandatory reporting, and we retrieved aggregated data on all verified cases until 3 March 2021 from the Public Health Agency of Sweden. The SIR in Ronneby was estimated at 1.19 (95% CI: 1.12; 1.27). The results suggest a potential link between high PFAS exposure and susceptibility to COVID-19 that warrants further research to clarify causality.", "doi": "10.3390/ijerph182010702", "pmid": "34682448", "labels": {"Category: Health": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8535293"}, {"db": "pii", "key": "ijerph182010702"}], "notes": [], "created": "2021-10-26T18:16:13.491Z", "modified": "2023-06-19T14:58:56.423Z"}, {"entity": "publication", "iuid": "67ed46cf180649afb240d1aa9ebef4e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/67ed46cf180649afb240d1aa9ebef4e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/67ed46cf180649afb240d1aa9ebef4e1"}}, "title": "Public justification and expert disagreement over non-pharmaceutical interventions for the COVID-19 pandemic.", "authors": [{"family": "Dahlquist", "given": "Marcus", "initials": "M"}, {"family": "Kugelberg", "given": "Henrik D", "initials": "HD", "orcid": "0000-0001-5119-646X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7330f66aa494bd1af8c79f6c9040620.json"}}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "J Med Ethics", "issn": "1473-4257", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "A wide range of non-pharmaceutical interventions (NPIs) have been introduced to stop or slow down the COVID-19 pandemic. Examples include school closures, environmental cleaning and disinfection, mask mandates, restrictions on freedom of assembly and lockdowns. These NPIs depend on coercion for their effectiveness, either directly or indirectly. A widely held view is that coercive policies need to be publicly justified-justified to each citizen-to be legitimate. Standardly, this is thought to entail that there is a scientific consensus on the factual propositions that are used to support the policies. In this paper, we argue that such a consensus has been lacking on the factual propositions justifying most NPIs. Consequently, they would on the standard view be illegitimate. This is regrettable since there are good reasons for granting the state the legitimate authority to enact NPIs under conditions of uncertainty. The upshot of our argument is that it is impossible to have both the standard interpretation of the permissibility of empirical claims in public justification and an effective pandemic response. We provide an alternative view that allows the state sufficient room for action while precluding the possibility of it acting without empirical support.", "doi": "10.1136/medethics-2021-107671", "pmid": "34642238", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "medethics-2021-107671"}], "notes": [], "created": "2021-10-21T05:08:50.893Z", "modified": "2022-02-17T11:29:15.608Z"}, {"entity": "publication", "iuid": "cbcfcaa21cfc4797bf135d15cff0e99a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cbcfcaa21cfc4797bf135d15cff0e99a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cbcfcaa21cfc4797bf135d15cff0e99a"}}, "title": "Prospective epidemiological, molecular, and genetic characterization of a novel coronavirus disease in the Val Venosta/Vinschgau: the CHRIS COVID-19 study protocol.", "authors": [{"family": "Pattaro", "given": "Cristian", "initials": "C", "orcid": "0000-0002-4119-0109", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf5065dd0f28451cbbe933b4a7de5985.json"}}, {"family": "Barbieri", "given": "Giulia", "initials": "G"}, {"family": "Foco", "given": "Luisa", "initials": "L", "orcid": "0000-0002-6694-3322", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/302e8d33f5154cfa9e61bae73c23eb36.json"}}, {"family": "Weichenberger", "given": "Christian X", "initials": "CX", "orcid": "0000-0002-2176-0274", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f73be54674f47cdb15cb55f83210783.json"}}, {"family": "Biasiotto", "given": "Roberta", "initials": "R"}, {"family": "De Grandi", "given": "Alessandro", "initials": "A"}, {"family": "Fuchsberger", "given": "Christian", "initials": "C"}, {"family": "Egger", "given": "Clemens", "initials": "C"}, {"family": "Amon", "given": "Vera S C", "initials": "VSC"}, {"family": "Hicks", "given": "Andrew A", "initials": "AA"}, {"family": "Mian", "given": "Michael", "initials": "M"}, {"family": "Mahlknecht", "given": "Angelika", "initials": "A"}, {"family": "Lombardo", "given": "Stefano", "initials": "S"}, {"family": "Meier", "given": "Horand", "initials": "H"}, {"family": "Weiss", "given": "Helmuth", "initials": "H"}, {"family": "Rainer", "given": "Robert", "initials": "R"}, {"family": "Dejaco", "given": "Christian", "initials": "C"}, {"family": "Weiss", "given": "G\u00fcnter", "initials": "G"}, {"family": "Lavezzo", "given": "Enrico", "initials": "E", "orcid": "0000-0002-3902-8356", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fdd6f6eb77a4a589afafc12955ca8d6.json"}}, {"family": "Crisanti", "given": "Andrea", "initials": "A"}, {"family": "Pizzato", "given": "Massimo", "initials": "M"}, {"family": "Domingues", "given": "Francisco S", "initials": "FS"}, {"family": "Mascalzoni", "given": "Deborah", "initials": "D"}, {"family": "G\u00f6gele", "given": "Martin", "initials": "M"}, {"family": "Melotti", "given": "Roberto", "initials": "R", "orcid": "0000-0003-4115-317X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9aadc5f020e74449a6ad0f6b87c55ec1.json"}}, {"family": "Pramstaller", "given": "Peter P", "initials": "PP"}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "Pathog Glob Health", "issn": "2047-7732", "pages": "1-9", "issn-l": null}, "abstract": "The COVID-19 pandemic has been threatening the healthcare and socioeconomic systems of entire nations. While population-based surveys to assess the distribution of SARS-CoV-2 infection have become a priority, pre-existing longitudinal studies are ideally suited to assess the determinants of COVID-19 onset and severity.The Cooperative Health Research In South Tyrol (CHRIS) study completed the baseline recruitment of 13,393 adults from the Venosta/Vinschgau rural district in 2018, collecting extensive phenotypic and biomarker data, metabolomic data, densely imputed genotype and whole-exome sequencing data.Based on CHRIS, we designed a prospective study, called CHRIS COVID-19, aimed at: 1) estimating the incidence of SARS-CoV-2 infections; 2) screening for and investigating the determinants of incident infection among CHRIS participants and their household members; 3) monitoring the immune response of infected participants prospectively.An online screening questionnaire was sent to all CHRIS participants and their household members. A random sample of 1450 participants representative of the district population was invited to assess active (nasopharyngeal swab) or past (serum antibody test) infections. We prospectively invited for complete SARS-CoV-2 testing all questionnaire completers gauged as possible cases of past infection and their household members. In positive tested individuals, antibody response is monitored quarterly for one year. Untested and negative participants receive the screening questionnaire every four weeks until gauged as possible incident cases or till the study end.Originated from a collaboration between researchers and community stakeholders, the CHRIS COVID-19 study aims at generating knowledge about the epidemiological, molecular, and genetic characterization of COVID-19 and its long-term sequelae.", "doi": "10.1080/20477724.2021.1978225", "pmid": "34637685", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8515786"}], "notes": [], "created": "2021-10-21T05:29:17.156Z", "modified": "2021-10-21T05:29:17.348Z"}, {"entity": "publication", "iuid": "ecfd334996f743f4b1001cd1f885ea98", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ecfd334996f743f4b1001cd1f885ea98.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ecfd334996f743f4b1001cd1f885ea98"}}, "title": "Organising labour market integration support for refugees in Austria and Sweden during the Covid-19 pandemic.", "authors": [{"family": "Be\u0161i\u0107", "given": "Almina", "initials": "A", "orcid": "0000-0003-4587-3609", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83a02c2a27944f7f8f3bf383b1dc1957.json"}}, {"family": "Diedrich", "given": "Andreas", "initials": "A"}, {"family": "Aigner", "given": "Petra", "initials": "P"}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "Comp Migr Stud", "issn": "2214-594X", "volume": "9", "issue": "1", "pages": "48", "issn-l": null}, "abstract": "This paper addresses the question of how the Covid-19 pandemic has affected the labour market integration support (LMIS) organised for refugees in Austria and Sweden, and the potential consequences of the changes unfolding. LMIS for refugees is a complex phenomenon involving actors at different interwoven levels-the macro-national level, the meso-organisational level and the micro-individual level. However, the complexities and consequences of such processes for the labour market integration of refugees have so far received limited attention. The current Covid-19 pandemic actualises the need to gain a better understanding of how integration support is organised across the different levels and how the pandemic itself impacts such support. Thus, the article seeks to understand how the pandemic affects the LMIS organised for refugees in Austria and Sweden, two countries with a large refugee population and diverging responses to the pandemic. Based on 29 semi-structured interviews and three focus group workshops, the results highlight in particular three developments: (a) a further entrenching of broader, macro-national level developments related to integration support already underway prior to the pandemic; (b) further mainstreaming of activities; and (c) increased volatility of work. Overall, the pandemic has brought to the fore the interrelation of different levels in the organising of LMIS for refugees and has contributed to a stabilisation of already ongoing activities.", "doi": "10.1186/s40878-021-00264-y", "pmid": "34660206", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "264"}, {"db": "pmc", "key": "PMC8507501"}], "notes": [], "created": "2021-10-21T05:01:14.127Z", "modified": "2021-10-21T05:01:14.195Z"}, {"entity": "publication", "iuid": "c54f0b8881fc4d8986c0453d0633d8d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c54f0b8881fc4d8986c0453d0633d8d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c54f0b8881fc4d8986c0453d0633d8d7"}}, "title": "High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells.", "authors": [{"family": "Sasamoto", "given": "Yuzuru", "initials": "Y"}, {"family": "Lee", "given": "Catherine A A", "initials": "CAA"}, {"family": "Yoshihara", "given": "Masahito", "initials": "M"}, {"family": "Martin", "given": "Gabrielle", "initials": "G"}, {"family": "Ksander", "given": "Bruce R", "initials": "BR"}, {"family": "Frank", "given": "Markus H", "initials": "MH"}, {"family": "Frank", "given": "Natasha Y", "initials": "NY"}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "Ocul Surf", "issn": "1937-5913", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jtos.2021.10.002", "pmid": "34653711", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1542-0124(21)00119-1"}], "notes": [], "created": "2021-10-21T05:04:34.147Z", "modified": "2021-10-21T05:04:34.184Z"}, {"entity": "publication", "iuid": "f78ed0896ec04ae2b27fe862816fab97", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f78ed0896ec04ae2b27fe862816fab97.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f78ed0896ec04ae2b27fe862816fab97"}}, "title": "Dynamic Interactions of Fully Glycosylated SARS-CoV-2 Spike Protein with Various Antibodies.", "authors": [{"family": "Cao", "given": "Yiwei", "initials": "Y", "orcid": "0000-0002-4516-8689", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15efd17a7c1342a3aa46bab1e2b9e241.json"}}, {"family": "Choi", "given": "Yeol Kyo", "initials": "YK", "orcid": "0000-0002-4218-7139", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2885ea927174b0aabe0ab76d5fba484.json"}}, {"family": "Frank", "given": "Martin", "initials": "M", "orcid": "0000-0002-1006-6746", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee6b5d165615455da3cf49fad65598e9.json"}}, {"family": "Woo", "given": "Hyeonuk", "initials": "H", "orcid": "0000-0002-6495-4087", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2dfd6c1c6f34de2b6b768ce70a67ebb.json"}}, {"family": "Park", "given": "Sang-Jun", "initials": "SJ", "orcid": "0000-0002-7307-3724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dede807702c34573bfe7de0b40c48de9.json"}}, {"family": "Yeom", "given": "Min Sun", "initials": "MS", "orcid": "0000-0001-9977-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7ae6fb73cfb47199fd5e4a468aa5554.json"}}, {"family": "Seok", "given": "Chaok", "initials": "C", "orcid": "0000-0002-1419-9888", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a93933221aa54cda9547eb7f063c154c.json"}}, {"family": "Im", "given": "Wonpil", "initials": "W", "orcid": "0000-0001-5642-6041", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c6b1fc87fa647459c5a112e9fa6b8ce.json"}}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "J Chem Theory Comput", "issn": "1549-9626", "issn-l": null, "volume": "17", "issue": "10", "pages": "6559-6569"}, "abstract": "The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents a public health crisis, and the vaccines that can induce highly potent neutralizing antibodies are essential for ending the pandemic. The spike (S) protein on the viral envelope mediates human angiotensin-converting enzyme 2 binding and thus is the target of a variety of neutralizing antibodies. In this work, we built various S trimer-antibody complex structures on the basis of the fully glycosylated S protein models described in our previous work and performed all-atom molecular dynamics simulations to gain insight into the structural dynamics and interactions between S protein and antibodies. Investigation of the residues critical for S-antibody binding allows us to predict the potential influence of mutations in SARS-CoV-2 variants. Comparison of the glycan conformations between S-only and S-antibody systems reveals the roles of glycans in S-antibody binding. In addition, we explored the antibody binding modes and the influences of antibody on the motion of S protein receptor binding domains. Overall, our analyses provide a better understanding of S-antibody interactions, and the simulation-based S-antibody interaction maps could be used to predict the influences of S mutation on S-antibody interactions, which will be useful for the development of vaccine and antibody-based therapy.", "doi": "10.1021/acs.jctc.1c00552", "pmid": "34529436", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null, "Category: Health": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC8457324"}], "notes": [], "created": "2021-09-20T16:50:33.864Z", "modified": "2023-06-19T14:35:10.854Z"}, {"entity": "publication", "iuid": "81d66a14c5ca493c826d3c9f0a089ec6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/81d66a14c5ca493c826d3c9f0a089ec6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/81d66a14c5ca493c826d3c9f0a089ec6"}}, "title": "Changes in Physical Activity Are Associated with Corresponding Changes in Psychological Well-Being: A Pandemic Case Study.", "authors": [{"family": "Dahlen", "given": "Micael", "initials": "M", "orcid": "0000-0001-6183-6520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5135c7c73d7f4eb89e26ec713dbfa2b8.json"}}, {"family": "Thorbj\u00f8rnsen", "given": "Helge", "initials": "H", "orcid": "0000-0002-2037-3336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46491c54156e4bdc85d376feda0fe55c.json"}}, {"family": "Sj\u00e5stad", "given": "Hallgeir", "initials": "H", "orcid": "0000-0002-8730-1038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9d4b3d4379f4e3bb43607c0ef08f159.json"}}, {"family": "von Heideken W\u00e5gert", "given": "Petra", "initials": "P", "orcid": "0000-0001-6292-7010", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4d6dfb26a37419385eb8e257f89d950.json"}}, {"family": "Hellstr\u00f6m", "given": "Charlotta", "initials": "C", "orcid": "0000-0003-1675-4408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a211ac4b50f24a3ca7be0deb42bc3362.json"}}, {"family": "Kerstis", "given": "Birgitta", "initials": "B", "orcid": "0000-0003-0242-0343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b50ad01a7fdd43b589b7ec07cf98f220.json"}}, {"family": "Lindberg", "given": "Daniel", "initials": "D", "orcid": "0000-0002-8541-1727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f40c1556e4545a3a69893d276425af9.json"}}, {"family": "Stier", "given": "Jonas", "initials": "J", "orcid": "0000-0001-7832-2155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7bd46d9d05214eef8e677e69a8878291.json"}}, {"family": "Elv\u00e9n", "given": "Maria", "initials": "M", "orcid": "0000-0001-5356-916X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d90589956db4920b99e166ed4c6dfb2.json"}}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "20", "pages": null}, "abstract": "Societal crises and personal challenges are often followed by substantial changes in physical activity. Is there a link between such changes and psychological well-being? Seeking to answer this question, we conducted a correlational study on a representative sample in Sweden during the first year of the COVID-19 pandemic (N = 1035). About 49% of the sample had decreased their physical activity compared to their self-reported activity level prior to the pandemic, whereas 32% had increased it. The results showed a positive and robust association between changes in daily activity level and corresponding changes in psychological well-being. Specifically, individuals who had reduced their physical activity over the last year reported lower life satisfaction than before, and individuals who had increased their physical activity reported higher life satisfaction than before. The amount of complete physical inactivity (sitting) showed a similar pattern as the exercise data, meaning that individuals who reported increasing inactivity per day also reported a greater decline in life satisfaction. Additional analyses showed that the association between daily activity level and life satisfaction was somewhat stronger for men than for women, but there was no difference when comparing individual versus organized activities. The current study was based on a cross-sectional design, measuring self-reported change over time. Recent work from other research teams have used longitudinal data and experience-sampling in different settings, finding similar results. We conclude that there is good reason to recommend physical exercise as a coping strategy in difficult times.", "doi": "10.3390/ijerph182010680", "pmid": "34682427", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "ijerph182010680"}], "notes": [], "created": "2021-10-26T18:14:07.931Z", "modified": "2022-02-17T10:50:21.789Z"}, {"entity": "publication", "iuid": "fcbefce66e1c493f8ecbc002ec69bd19", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fcbefce66e1c493f8ecbc002ec69bd19.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fcbefce66e1c493f8ecbc002ec69bd19"}}, "title": "What has the COVID-19 pandemic taught us about conducting patient and public involvement remotely? Insights from a series of digital meeting observations.", "authors": [{"family": "Lampa", "given": "Elin", "initials": "E", "orcid": "0000-0002-5467-5850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ca616474534489e933171c9819c3869.json"}}, {"family": "Sonnentheil", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "T\u00f6k\u00e9s", "given": "Ant\u00f3nia", "initials": "A"}, {"family": "Warner", "given": "Georgina", "initials": "G"}], "type": "letter", "published": "2021-10-11", "journal": {"title": "Res Involv Engagem", "issn": "2056-7529", "issn-l": null, "volume": "7", "issue": "1", "pages": "73"}, "abstract": "During the COVID-19 pandemic many work tasks are being done remotely through digital meetings, including PPI in research. Yet, some PPI activities have been paused or cancelled altogether during the pandemic. In this commentary, we share our insights from observing digital meetings with researchers and public contributors, representing vulnerable groups. Additionally, we discuss how remote PPI activities can be understood and improved.\r\n\r\nAs part of a PPI evaluation project, live observations were conducted by two trained observers, using a semi-structured observation protocol developed to objectively assess aspects of group dynamics in PPI research meetings with public contributors with experience of seeking refuge and parents facing economic hardship. This project's data collection is ongoing and the insights in this commentary is based on the observers' discussion. We discuss these insights through the lens of the Media Richness Theory, stating that the choice of media we communicate through should be guided by what kind of information we want to communicate to each other. The more complex the information is, the richer the media tool needs to be. For example, information in a text message is more easily misinterpreted than information given in person. This is because meeting in person gives us more information, for example through body language and tone of voice. Based on our experiences from observing digital research meetings, we give suggestions on how to improve digital meetings with public contributors. A few key points are: actively choosing which media to use; being prepared to guide contributors to the chosen media in a way that is suitable for them; and the increased importance of the person chairing the meeting to actively include all participants.\r\n\r\nWe reach the conclusion that digital meetings with public contributors is possible, but that researchers need to make a commitment and actively work to solve practical issues. Finally, the format and structure of digital meetings should be co-created together with public contributors.", "doi": "10.1186/s40900-021-00315-9", "pmid": "34635179", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s40900-021-00315-9"}, {"db": "pmc", "key": "PMC8503706"}], "notes": [], "created": "2021-10-21T05:40:42.818Z", "modified": "2022-02-17T10:29:45.446Z"}, {"entity": "publication", "iuid": "f20b9edbcf6644cf8ffc8e845358ae08", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f20b9edbcf6644cf8ffc8e845358ae08.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f20b9edbcf6644cf8ffc8e845358ae08"}}, "title": "Time-dependent evolution of IgG antibody levels after first and second dose of mRNA-based SARS-CoV-2 vaccination in hemodialysis patients: a multicenter study.", "authors": [{"family": "Santos-Ara\u00fajo", "given": "Carla", "initials": "C"}, {"family": "Veiga", "given": "Pedro Mota", "initials": "PM"}, {"family": "Santos", "given": "M\u00e1rio Jo\u00e3o", "initials": "MJ"}, {"family": "Santos", "given": "Lidia", "initials": "L"}, {"family": "Rom\u00e3ozinho", "given": "Catarina", "initials": "C"}, {"family": "Silva", "given": "M\u00f3nica", "initials": "M"}, {"family": "Lucas", "given": "Carlos", "initials": "C"}, {"family": "Duarte", "given": "Mary Luz", "initials": "ML"}, {"family": "Haarhaus", "given": "Mathias", "initials": "M"}, {"family": "Haase", "given": "Michael", "initials": "M"}, {"family": "Mac\u00e1rio", "given": "Fernando", "initials": "F"}], "type": "journal article", "published": "2021-10-11", "journal": {"title": "Nephrol Dial Transplant", "issn": "1460-2385", "issn-l": "0931-0509"}, "abstract": "Vaccination programs are essential for the containment of the COVID-19 pandemic, which has affected hemodialysis populations especially hard. Early reports suggest a reduced immunologic response to SARS-Cov-2 vaccines in dialysis patients, in spite of a high degree of seroconversion. We aimed to identify risk factors for a reduced efficacy of an mRNA vaccine in a cohort of hemodialysis patients.\n\nIn a multicenter study, including 294 Portuguese hemodialysis patients who had received 2 doses of BNT162b2 with a three week interval, IgG-class antibodies against the SARS-CoV-2 spike protein were determined 3 weeks after the first dose (M1) and 6 weeks after the second dose (M2). The threshold for seroconversion was 10UR/mL. Demographic and clinical data was retrieved from a quality registry. Adverse events were registered using a questionnaire.\n\nAt M2, seroconversion was 93.1% with a median antibody level of 197.5U/mL (1.2-3237.0) and a median increase of 180.0U/mL (-82.9-2244.6) from M1. Age (beta -8.9; 95%CI: -12.88 to -4.91; P < 0.0001), ferritin > 600ng/mL (beta 183.93; 95%CI: 74.75 to 293.10; P = 0.001) and physical activity (beta 265.79; 95%CI: 30.7 to 500.88; P = 0.03) were independent predictors of SARS-Cov-2 antibody levels after two vaccine doses. Plasma albumin > 3.5g/dL independently predicted the increase of antibody levels between both doses (OR 14.72; 95%CI: 1.38 to 157.45; P = 0.03). Only mild adverse reactions were observed in 10.9% of patients.\n\nThe SARS-Cov-2 vaccine BNT162b2 is safe and effective in hemodialysis patients. Besides age, iron status and nutrition are possible modifiable modulators of the immunologic response to SARS-Cov-2 mRNA vaccines. This data suggests the need for an early identification of populations at higher risk for diminished antibody production and the potential advantage of the implementation of oriented strategies to maximize the immune response to vaccination in these patients.", "doi": "10.1093/ndt/gfab293", "pmid": "34634116", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "6388402"}], "notes": [], "created": "2021-10-21T05:41:56.358Z", "modified": "2021-10-21T05:42:07.316Z"}, {"entity": "publication", "iuid": "278a382c799044f9b790db547410274d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/278a382c799044f9b790db547410274d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/278a382c799044f9b790db547410274d"}}, "title": "Longitudinal experiences and impact of the COVID-19 pandemic among people with past or current eating disorders in Sweden.", "authors": [{"family": "Birgeg\u00e5rd", "given": "Andreas", "initials": "A", "orcid": "0000-0003-1220-9680", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ffef11fa1954f97b80d3d3a6817e71a.json"}}, {"family": "Abbaspour", "given": "Afrouz", "initials": "A"}, {"family": "Borg", "given": "Stina", "initials": "S"}, {"family": "Clinton", "given": "David", "initials": "D"}, {"family": "Mantilla", "given": "Emma Fors\u00e9n", "initials": "EF"}, {"family": "Savva", "given": "Androula", "initials": "A"}, {"family": "Termorshuizen", "given": "Jet D", "initials": "JD"}, {"family": "Bulik", "given": "Cynthia M", "initials": "CM"}], "type": "journal article", "published": "2021-10-11", "journal": {"title": "Eat Disord", "issn": "1532-530X", "pages": "1-16", "issn-l": null}, "abstract": "The study aimed to document the impact of the COVID-19 pandemic on the health and well-being of individuals with past and current eating disorders (ED) in Sweden. We re-contacted participants with a known lifetime history of ED from two previous Swedish studies. Participants completed an online survey about health and functioning at baseline early in the pandemic (Wave 1 ca May/June 2020; N= 982) and six months later (Wave 2 Dec/Jan 2020/21; N= 646). Three important patterns emerged: 1) higher current ED symptoms were associated with greater anxiety, worry, and pandemic-related ED symptom increase; 2) patterns were fairly stable across time, although a concerning percentage (23%) who were symptom-free at Wave 1 reported the re-emergence of symptoms at Wave 2; and 3) only a minority of participants (<50%) with a current ED were in treatment, and of those in treatment, many reported fewer treatment sessions and decreased quality of care. The COVID-19 pandemic appears to pose serious health challenges for individuals with an ED, whether currently symptomatic or in remission. We encourage health service providers and patient advocates to be alert to the needs of individuals with ED and to take active measures to ensure access to appropriate evidence-based care both during and following the pandemic.", "doi": "10.1080/10640266.2021.1985286", "pmid": "34634228", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-21T05:41:17.737Z", "modified": "2021-10-21T05:41:17.812Z"}, {"entity": "publication", "iuid": "0bfed88b3c994d329226611fc1d5840d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0bfed88b3c994d329226611fc1d5840d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0bfed88b3c994d329226611fc1d5840d"}}, "title": "Increased risk of hospitalisation and intensive care admission associated with reported cases of SARS-CoV-2 variants B.1.1.7 and B.1.351 in Norway, December 2020 -May 2021.", "authors": [{"family": "Veneti", "given": "Lamprini", "initials": "L", "orcid": "0000-0002-9117-5310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/692998f77204424dba01972130b83448.json"}}, {"family": "Sepp\u00e4l\u00e4", "given": "Elina", "initials": "E"}, {"family": "Larsdatter Storm", "given": "Margrethe", "initials": "M"}, {"family": "Valcarcel Salamanca", "given": "Beatriz", "initials": "B"}, {"family": "Alnes Buanes", "given": "Eirik", "initials": "E"}, {"family": "Aasand", "given": "Nina", "initials": "N"}, {"family": "Naseer", "given": "Umaer", "initials": "U"}, {"family": "Bragstad", "given": "Karoline", "initials": "K"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "B\u00f8\u00e5s", "given": "H\u00e5kon", "initials": "H"}, {"family": "Kv\u00e5le", "given": "Reidar", "initials": "R"}, {"family": "Golestani", "given": "Karan", "initials": "K"}, {"family": "Feruglio", "given": "Siri", "initials": "S"}, {"family": "Vold", "given": "Line", "initials": "L"}, {"family": "Nyg\u00e5rd", "given": "Karin", "initials": "K"}, {"family": "Whittaker", "given": "Robert", "initials": "R", "orcid": "0000-0003-2810-7734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be98797b0c2a4de68e6e9599e4d1fb0e.json"}}], "type": "journal article", "published": "2021-10-11", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0258513", "issn-l": "1932-6203"}, "abstract": "Since their emergence, SARS-CoV-2 variants of concern (VOC) B.1.1.7 and B.1.351 have spread worldwide. We estimated the risk of hospitalisation and admission to an intensive care unit (ICU) for infections with B.1.1.7 and B.1.351 in Norway, compared to infections with non-VOC.\n\nUsing linked individual-level data from national registries, we conducted a cohort study on laboratory-confirmed cases of SARS-CoV-2 in Norway diagnosed between 28 December 2020 and 2 May 2021. Variants were identified based on whole genome sequencing, partial sequencing by Sanger sequencing or PCR screening for selected targets. The outcome was hospitalisation or ICU admission. We calculated adjusted risk ratios (aRR) with 95% confidence intervals (CIs) using multivariable binomial regression to examine the association between SARS-CoV-2 variants B.1.1.7 and B.1.351 with i) hospital admission and ii) ICU admission compared to non-VOC.\n\nWe included 23,169 cases of B.1.1.7, 548 B.1.351 and 4,584 non-VOC. Overall, 1,017 cases were hospitalised (3.6%) and 206 admitted to ICU (0.7%). B.1.1.7 was associated with a 1.9-fold increased risk of hospitalisation (aRR 95%CI 1.6-2.3) and a 1.8-fold increased risk of ICU admission (aRR 95%CI 1.2-2.8) compared to non-VOC. Among hospitalised cases, no difference was found in the risk of ICU admission between B.1.1.7 and non-VOC. B.1.351 was associated with a 2.4-fold increased risk of hospitalisation (aRR 95%CI 1.7-3.3) and a 2.7-fold increased risk of ICU admission (aRR 95%CI 1.2-6.5) compared to non-VOC.\n\nOur findings add to the growing evidence of a higher risk of severe disease among persons infected with B.1.1.7 or B.1.351. This highlights the importance of prevention and control measures to reduce transmission of these VOC in society, particularly ongoing vaccination programmes, and preparedness plans for hospital surge capacity.", "doi": "10.1371/journal.pone.0258513", "pmid": "34634066", "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-21292"}, {"db": "pmc", "key": "PMC8504717"}], "notes": [], "created": "2021-10-21T05:42:38.657Z", "modified": "2021-10-21T05:42:38.755Z"}, {"entity": "publication", "iuid": "ad0ade1d4f684a8e8ba203c034450fec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ad0ade1d4f684a8e8ba203c034450fec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ad0ade1d4f684a8e8ba203c034450fec"}}, "title": "Covid-19: Sweden, Norway, and Finland suspend use of Moderna vaccine in young people \"as a precaution\".", "authors": [{"family": "Paterlini", "given": "Marta", "initials": "M"}], "type": "journal article", "published": "2021-10-11", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "375", "pages": "n2477", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.n2477", "pmid": "34635488", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-10-21T05:31:27.906Z", "modified": "2021-10-21T05:31:27.921Z"}, {"entity": "publication", "iuid": "7e5e4f36da9748f9a7017365af6f787b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e5e4f36da9748f9a7017365af6f787b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e5e4f36da9748f9a7017365af6f787b"}}, "title": "Association Between Risk of COVID-19 Infection in Nonimmune Individuals and COVID-19 Immunity in Their Family Members.", "authors": [{"family": "Nordstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Ballin", "given": "Marcel", "initials": "M"}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-10-11", "journal": {"title": "JAMA Intern Med", "issn": "2168-6114", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The association between COVID-19 immunity within families and the risk of infection in nonimmune family members is unknown.\r\n\r\nTo investigate the association between risk of COVID-19 in nonimmune individuals and the number of their family members with known immunity acquired from a previous COVID-19 infection or full vaccination (2 vaccine doses).\r\n\r\nIn this cohort study of data from nationwide registries in Sweden, all individuals who acquired immunity from either previous COVID-19 infection or full vaccination until May 26, 2021, were considered for inclusion. Each person with immunity was matched 1:1 to an individual without immunity from an identified cohort of individuals with families comprising 2 to 5 members.\r\n\r\nNumber of immune family members in each family on April 14, 2021 (index date), who acquired immunity from a previous COVID-19 infection or full vaccination (2 doses of the mRNA-1273, BNT162b2 mRNA, or ChAdOx1 nCoV-19 vaccine).\r\n\r\nIncident COVID-19 infection in nonimmune family members from April 15 to May 26, 2021.\r\n\r\nA total of 1 789 728 individuals from 814 806 families were included in the analysis. Each family comprised 2 to 5 family members, with a mean (SD) age at baseline of 51.3 (19.5) years. During a mean (range) follow-up time of 26.3 (1-40) days, 88 797 of 1 549 989 (5.7%) nonimmune family members (mean [SD] age, 51.6 [17.7] years; 790 276 men [51.0%]) were diagnosed with COVID-19. There was an inverse dose-response association between the number of immune members in each family and the risk of incident COVID-19 infection in nonimmune family members. Nonimmune families with 1 immune family member had a 45% to 61% lower risk of contracting COVID-19 (hazard ratio [HR], 0.39-0.55; 95% CI, 0.37-0.61, P < .001). The risk reduction increased to 75% to 86% in families with 2 immune family members (HR, 0.14-0.25; 95% CI, 0.11-0.27; P < .001), 91% to 94% with 3 immune family members (HR, 0.06-0.09; 95% CI, 0.04-0.10; P < .001), and 97% with 4 immune family members (HR, 0.03; 95% CI, 0.02-0.05; P < .001). The results were similar for the outcome of COVID-19 infection that was severe enough to warrant a hospital stay.\r\n\r\nIn this cohort study, family members without immunity had a 45% to 97% lower risk of contracting COVID-19 as the number of immune family members increased. Vaccination is a key strategy for decreasing the transmission of the virus within families.", "doi": "10.1001/jamainternmed.2021.5814", "pmid": "34633407", "labels": {"Type: Journal article": null, "Category: Proteins": null}, "xrefs": [{"db": "pii", "key": "2785141"}], "notes": [], "created": "2021-10-21T05:44:00.849Z", "modified": "2021-10-21T05:45:09.824Z"}, {"entity": "publication", "iuid": "203b5fbee3e144d39ec6f59bfc384379", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/203b5fbee3e144d39ec6f59bfc384379.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/203b5fbee3e144d39ec6f59bfc384379"}}, "title": "Conquering the cytokine storm in COVID\u201019\u2010induced ARDS using placenta\u2010derived decidua stromal cells", "authors": [{"family": "Sadeghi", "given": "Behnam", "initials": "B", "orcid": "0000-0002-8721-0400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eadac43380f04ff58c964c3510e92151.json"}}, {"family": "Roshandel", "given": "Elham", "initials": "E"}, {"family": "Pirsalehi", "given": "Ali", "initials": "A"}, {"family": "Kazemi", "given": "Sepide", "initials": "S"}, {"family": "Sankanian", "given": "Ghazaleh", "initials": "G"}, {"family": "Majidi", "given": "Mohammad", "initials": "M"}, {"family": "Salimi", "given": "Maryam", "initials": "M"}, {"family": "Aghdami", "given": "Nasser", "initials": "N"}, {"family": "Sadrosadat", "given": "Hoda", "initials": "H"}, {"family": "Samadi Kochaksaraei", "given": "Sarvenaz", "initials": "S"}, {"family": "Alaeddini", "given": "Farshid", "initials": "F"}, {"family": "Ringden", "given": "Olle", "initials": "O"}, {"family": "Hajifathali", "given": "Abbas", "initials": "A"}], "type": "journal-article", "published": "2021-10-10", "journal": {"title": "J Cell Mol Med", "issn": "1582-1838", "issn-l": null}, "abstract": null, "doi": "10.1111/jcmm.16986", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:47:38.250Z", "modified": "2021-10-11T17:47:38.334Z"}, {"entity": "publication", "iuid": "64dc4d035e764b2593cd8aa0b4b542a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/64dc4d035e764b2593cd8aa0b4b542a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/64dc4d035e764b2593cd8aa0b4b542a4"}}, "title": "Transition to telehealth : Engaging medical students in telemedicine healthcare delivery.", "authors": [{"family": "Cheng", "given": "Chelsea", "initials": "C"}, {"family": "Humphreys", "given": "Hilary", "initials": "H", "orcid": "0000-0002-9646-2183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/743d1ac7fae6414881cdbbfd68ee700d.json"}}, {"family": "Kane", "given": "Bridget", "initials": "B", "orcid": "0000-0003-3211-6529", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4805745c1bc64db79cb7de66a19c24b9.json"}}], "type": "journal article", "published": "2021-10-09", "journal": {"title": "Ir J Med Sci", "issn": "1863-4362", "issn-l": null}, "abstract": "In recent years, telemedicine has been increasingly incorporated into medical practice, a process which has now been accelerated by the COVID-19 pandemic. As telemedicine continues to progress, it is necessary for medical institutions to incorporate telemedicine into their curricula, and to provide students with the necessary skills and experience to effectively carry out telemedicine consultations. The purposes of this study are to review the involvement of medical students with telemedicine and to determine both the benefits and the challenges experienced. A literature review on the MEDLINE; CINAHL Plus; APA PsychInfo; Library, Information Science and Technology Abstracts; and Health Business Elite databases was performed on September 7, 2020, yielding 561 results. 33 manuscripts were analysed, with the main benefits and challenges experienced by medical students summarized. In addition to increasing their understanding of the importance of telemedicine and the acquisition of telemedicine-specific skills, students may use telemedicine to act as a valuable workforce during the COVID-19 pandemic. Challenges that students face, such as discomfort with carrying out telemedicine consults and building rapport with patients, may be addressed through the incorporation of telemedicine teaching into the medical curricula through experiential learning. However, other more systemic challenges, such as technical difficulties and cost, need to be examined for the full benefits of telemedicine to be realized. Telemedicine is here to stay and has proven its worth during the COVID-19 pandemic, with medical students embracing its potential in assisting in medical clinics, simulation of clinical placements, and online classrooms.", "doi": "10.1007/s11845-021-02720-1", "pmid": "34626350", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11845-021-02720-1"}], "notes": [], "created": "2021-10-10T15:03:29.736Z", "modified": "2021-10-10T15:03:29.813Z"}, {"entity": "publication", "iuid": "9cf39ddf9f0c40979dc182c2bdcea414", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9cf39ddf9f0c40979dc182c2bdcea414.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9cf39ddf9f0c40979dc182c2bdcea414"}}, "title": "Severe COVID-19 among patients with asthma and COPD: a report from the Swedish National Airway Register.", "authors": [{"family": "Karlsson Sundbaum", "given": "Johanna", "initials": "J", "orcid": "0000-0001-5313-7981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8b5dfbfb761446aa474013fcccdd085.json"}}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW"}, {"family": "Konradsen", "given": "Jon R", "initials": "JR"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ekberg-Jansson", "given": "Ann", "initials": "A"}, {"family": "Stridsman", "given": "Caroline", "initials": "C", "orcid": "0000-0001-6622-3838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e2fc66fb68748eba5a7f8eb93c5ff3f.json"}}], "type": "journal article", "published": "2021-10-09", "journal": {"title": "Ther Adv Respir Dis", "issn": "1753-4666", "volume": "15", "pages": "17534666211049738", "issn-l": null}, "abstract": "Patients with obstructive lung diseases may be at risk of hospitalization and/or death due to COVID-19.\n\nTo estimate the frequency of severe COVID-19, and COVID-19-related mortality in a well-defined large population of patients with asthma and chronic inflammatory lung disease (COPD). Further to assess the frequency of asthma and COPD as registered comorbidities at discharge from hospital, and in death certificates.\n\nAt the start of the pandemic, the Swedish National Airway Register (SNAR) included 271,404 patients with a physician diagnosis of asthma and/or COPD. In September 2020, after the first COVID-19 wave in Sweden, the database was linked with the National Patient Register (NPR), the Swedish Intensive Care Register and the Swedish Cause of Death Register, which all provide data about COVID-19 based on International Classification of Diseases (ICD-10) codes. Severe COVID-19 was defined as hospitalization and/or intensive care or death due to COVID-19.\n\nAmong patients in SNAR, 0.5% with asthma, and 1.2% with COPD were identified with severe COVID-19. Among patients < 18 years with asthma, only 0.02% were severely infected. Of hospitalized adults, 14% with asthma and 29% with COPD died. Further, of patients in SNAR, 56% with asthma and 81% with COPD were also registered in the NPR, while on death certificates the agreement was lower (asthma 24% and COPD 71%).\n\nThe frequency of severe COVID-19 in asthma and COPD was relative low. Mortality for those hospitalized was double as high in COPD compared to asthma. Comorbid asthma and COPD were not always identified among patients with severe COVID-19.", "doi": "10.1177/17534666211049738", "pmid": "34623194", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:05:40.326Z", "modified": "2021-10-10T15:05:40.385Z"}, {"entity": "publication", "iuid": "79bc8a5e27924a4b85c44881e983c8fb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79bc8a5e27924a4b85c44881e983c8fb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79bc8a5e27924a4b85c44881e983c8fb"}}, "title": "Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: a systematic review and meta-analysis.", "authors": [{"family": "Vlieg-Boerstra", "given": "Berber", "initials": "B"}, {"family": "de Jong", "given": "Nicolette", "initials": "N"}, {"family": "Meyer", "given": "Rosan", "initials": "R"}, {"family": "Agostoni", "given": "Carlo", "initials": "C"}, {"family": "De Cosmi", "given": "Valentina", "initials": "V"}, {"family": "Grimshaw", "given": "Kate", "initials": "K"}, {"family": "Milani", "given": "Gregorio Paolo", "initials": "GP", "orcid": "0000-0003-3829-4254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ca1648b8a3104d04a1c1e76f1ab8515a.json"}}, {"family": "Muraro", "given": "Antonella", "initials": "A"}, {"family": "Oude Elberink", "given": "Hanneke", "initials": "H"}, {"family": "Pali-Sch\u00f6ll", "given": "Isabella", "initials": "I"}, {"family": "Roduit", "given": "Caroline", "initials": "C", "orcid": "0000-0002-5988-0570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e16166b1fbb40b7889c82489fbdb715.json"}}, {"family": "Sasaki", "given": "Mari", "initials": "M"}, {"family": "Skypala", "given": "Isabel", "initials": "I", "orcid": "0000-0003-3629-4293", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4c207bd30ab42c1867b02a860c67f77.json"}}, {"family": "Solokowska", "given": "Milena", "initials": "M"}, {"family": "van Splunter", "given": "Marloes", "initials": "M"}, {"family": "Untersmayr", "given": "Eva", "initials": "E", "orcid": "0000-0002-1963-499X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8992d441a29644549f96af3a610c41ed.json"}}, {"family": "Venter", "given": "Carina", "initials": "C", "orcid": "0000-0002-7473-5355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ad020ad75c949809aea99fc0b4a3e9b.json"}}, {"family": "O'Mahony", "given": "Liam", "initials": "L"}, {"family": "Nwaru", "given": "Bright I", "initials": "BI", "orcid": "0000-0002-2876-6089", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2cf3592613946dda1712a7e78dd4c73.json"}}], "type": "journal article", "published": "2021-10-09", "journal": {"title": "Allergy", "issn": "1398-9995", "issn-l": "0105-4538"}, "abstract": "It remains uncertain as to whether nutrient supplementation for the general population considered healthy could be useful in the prevention of RTIs, such as COVID-19. In this systematic review and meta-analysis the evidence was evaluated for primary prevention of any viral respiratory tract infection (RTI) such as SARS-CoV-2, through supplementation of nutrients with a recognized role in immune function: multiple micronutrients, vitamin A, folic acid, vitamin B12, C, D, E, beta-carotene, zinc, iron and long chain polyunsaturated fatty acids. The search produced 15,163 records of which 93 papers (based on 115 studies) met the inclusion criteria, resulting in 199,055 subjects (191,636 children and 7,419 adults) from 37 countries. Sixty-three studies were included in the meta-analyses, which was performed for children and adults separately. By stratifying the meta-analysis by world regions, only studies performed in Asia showed a significant, but heterogeneous protective effect of zinc supplementation on RTIs (RR 0.86, 95%CI 0.7-0.96, I2=79.1%, p=0.000). Vitamin D supplementation in adults significantly decreased the incidence of RTI (RR 0.89, 95%CI 0.79-0.99, p=0.272), particularly in North America (RR 0.82 95%CI 0.68-0.97), but not in Europe or Oceania. Supplementation of nutrients in the general population has either no, or at most a very limited effect on prevention of RTIs. Zinc supplementation appears protective for children in Asia, while vitamin D may protect adults in the USA and Canada. In 10/115 (8.7%) studies post-hoc analyses based on stratification for nutritional status was performed. In only one study zinc supplementation was found to be more effective in children with low zinc serum as compared to children with normal zinc serum levels.", "doi": "10.1111/all.15136", "pmid": "34626488", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:03:11.116Z", "modified": "2021-10-10T15:03:11.258Z"}, {"entity": "publication", "iuid": "017cd45892f94e0fa1011237ba243d3c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/017cd45892f94e0fa1011237ba243d3c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/017cd45892f94e0fa1011237ba243d3c"}}, "title": "Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.", "authors": [{"family": "Pablos", "given": "Isabel", "initials": "I"}, {"family": "Machado", "given": "Yoan", "initials": "Y"}, {"family": "de Jesus", "given": "Hugo C Ramos", "initials": "HCR"}, {"family": "Mohamud", "given": "Yasir", "initials": "Y"}, {"family": "Kappelhoff", "given": "Reinhild", "initials": "R"}, {"family": "Lindskog", "given": "Cecilia", "initials": "C"}, {"family": "Vlok", "given": "Marli", "initials": "M"}, {"family": "Bell", "given": "Peter A", "initials": "PA"}, {"family": "Butler", "given": "Georgina S", "initials": "GS"}, {"family": "Grin", "given": "Peter M", "initials": "PM"}, {"family": "Cao", "given": "Quynh T", "initials": "QT"}, {"family": "Nguyen", "given": "Jenny P", "initials": "JP"}, {"family": "Solis", "given": "Nestor", "initials": "N"}, {"family": "Abbina", "given": "Srinivas", "initials": "S"}, {"family": "Rut", "given": "Wioletta", "initials": "W"}, {"family": "Vederas", "given": "John C", "initials": "JC"}, {"family": "Szekely", "given": "Laszlo", "initials": "L"}, {"family": "Szakos", "given": "Attila", "initials": "A"}, {"family": "Drag", "given": "Marcin", "initials": "M"}, {"family": "Kizhakkedathu", "given": "Jayachandran N", "initials": "JN"}, {"family": "Mossman", "given": "Karen", "initials": "K"}, {"family": "Hirota", "given": "Jeremy A", "initials": "JA"}, {"family": "Jan", "given": "Eric", "initials": "E"}, {"family": "Luo", "given": "Honglin", "initials": "H"}, {"family": "Banerjee", "given": "Arinjay", "initials": "A"}, {"family": "Overall", "given": "Christopher M", "initials": "CM"}], "type": "journal article", "published": "2021-10-09", "journal": {"title": "Cell Rep", "issn": "2211-1247", "pages": "109892", "issn-l": null}, "abstract": "The main viral protease (3CLpro) is indispensable for SARS-CoV-2 replication. We delineate the human protein substrate landscape of 3CLpro by TAILS substrate-targeted N-terminomics. We identify more than 100 substrates in human lung and kidney cells supported by analyses of SARS-CoV-2-infected cells. Enzyme kinetics and molecular docking simulations of 3CLpro engaging substrates reveal how noncanonical cleavage sites, which diverge from SARS-CoV, guide substrate specificity. Cleaving the interactors of essential effector proteins, effectively stranding them from their binding partners, amplifies the consequences of proteolysis. We show that 3CLpro targets the Hippo pathway, including inactivation of MAP4K5, and key effectors of transcription, mRNA processing, and translation. We demonstrate that Spike glycoprotein directly binds galectin-8, with galectin-8 cleavage disengaging CALCOCO2/NDP52 to decouple antiviral-autophagy. Indeed, in post-mortem COVID-19 lung samples, NDP52 rarely colocalizes with galectin-8, unlike in healthy lungs. The 3CLpro substrate degradome establishes a foundational substrate atlas to accelerate exploration of SARS-CoV-2 pathology and drug design.", "doi": "10.1016/j.celrep.2021.109892", "pmid": "34672947", "labels": {"Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2211-1247(21)01362-0"}], "notes": [], "created": "2021-10-26T18:09:25.642Z", "modified": "2021-10-26T18:09:25.660Z"}, {"entity": "publication", "iuid": "8d509d3e380942b3b6dbddd4253d9966", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d509d3e380942b3b6dbddd4253d9966.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d509d3e380942b3b6dbddd4253d9966"}}, "title": "COVID-19 in patients with autoimmune diseases: characteristics and outcomes in a multinational network of cohorts across three countries.", "authors": [{"family": "Tan", "given": "Eng Hooi", "initials": "EH"}, {"family": "Sena", "given": "Anthony G", "initials": "AG", "orcid": "0000-0001-8630-5347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9202e069d9c24646b006b6abb640b541.json"}}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A", "orcid": "0000-0003-1202-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47f086bb6ccd49a2a5f11a32c06277c8.json"}}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Ahmed", "given": "Waheed-Ul-Rahman", "initials": "WU"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Duvall", "given": "Scott L", "initials": "SL"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "Bertolin", "given": "Sergio Fernandez", "initials": "SF"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Natarajan", "given": "Karthik", "initials": "K"}, {"family": "Falconer", "given": "Thomas", "initials": "T"}, {"family": "Spotnitz", "given": "Matthew", "initials": "M"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Blacketer", "given": "Clair", "initials": "C"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Lane", "given": "Jennifer C E", "initials": "JCE"}, {"family": "Dawoud", "given": "Dalia M", "initials": "DM"}, {"family": "Shah", "given": "Karishma", "initials": "K"}, {"family": "Yang", "given": "Yue", "initials": "Y"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Recalde", "given": "Martina", "initials": "M"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "Jonnagaddala", "given": "Jitendra", "initials": "J", "orcid": "0000-0002-9912-2344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8403290b9ec43fe93b558de97d84559.json"}}, {"family": "Subbian", "given": "Vignesh", "initials": "V"}, {"family": "Vizcaya", "given": "David", "initials": "D"}, {"family": "Lai", "given": "Lana Y H", "initials": "LYH"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Shah", "given": "Nigam H", "initials": "NH"}, {"family": "Gong", "given": "Mengchun", "initials": "M"}, {"family": "Vivekanantham", "given": "Arani", "initials": "A"}, {"family": "Abend", "given": "Aaron", "initials": "A"}, {"family": "Minty", "given": "Evan P", "initials": "EP"}, {"family": "Suchard", "given": "Marc", "initials": "M"}, {"family": "Rijnbeek", "given": "Peter", "initials": "P"}, {"family": "Ryan", "given": "Patrick B", "initials": "PB"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}], "type": "journal article", "published": "2021-10-09", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "volume": "60", "issue": "SI", "pages": "SI37-SI50", "issn-l": null}, "abstract": "Patients with autoimmune diseases were advised to shield to avoid coronavirus disease 2019 (COVID-19), but information on their prognosis is lacking. We characterized 30-day outcomes and mortality after hospitalization with COVID-19 among patients with prevalent autoimmune diseases, and compared outcomes after hospital admissions among similar patients with seasonal influenza.\n\nA multinational network cohort study was conducted using electronic health records data from Columbia University Irving Medical Center [USA, Optum (USA), Department of Veterans Affairs (USA), Information System for Research in Primary Care-Hospitalization Linked Data (Spain) and claims data from IQVIA Open Claims (USA) and Health Insurance and Review Assessment (South Korea). All patients with prevalent autoimmune diseases, diagnosed and/or hospitalized between January and June 2020 with COVID-19, and similar patients hospitalized with influenza in 2017-18 were included. Outcomes were death and complications within 30 days of hospitalization.\n\nWe studied 133 589 patients diagnosed and 48 418 hospitalized with COVID-19 with prevalent autoimmune diseases. Most patients were female, aged \u226550 years with previous comorbidities. The prevalence of hypertension (45.5-93.2%), chronic kidney disease (14.0-52.7%) and heart disease (29.0-83.8%) was higher in hospitalized vs diagnosed patients with COVID-19. Compared with 70 660 hospitalized with influenza, those admitted with COVID-19 had more respiratory complications including pneumonia and acute respiratory distress syndrome, and higher 30-day mortality (2.2-4.3% vs 6.32-24.6%).\n\nCompared with influenza, COVID-19 is a more severe disease, leading to more complications and higher mortality.", "doi": "10.1093/rheumatology/keab250", "pmid": "33725121", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6174122"}, {"db": "pmc", "key": "PMC7989171"}], "notes": [], "created": "2021-03-17T07:42:16.376Z", "modified": "2021-11-18T13:19:42.279Z"}, {"entity": "publication", "iuid": "a45f65dfd0c5498abfbfcc9164c2cb6c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a45f65dfd0c5498abfbfcc9164c2cb6c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a45f65dfd0c5498abfbfcc9164c2cb6c"}}, "title": "Rapid evaluation of Coronavirus Illness Severity (RECOILS) in intensive care: Development and validation of a prognostic tool for in-hospital mortality.", "authors": [{"family": "Ple\u010dko", "given": "Drago", "initials": "D", "orcid": "0000-0002-5433-196X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9f5f12451ca40b0a93e4f2491dd3a92.json"}}, {"family": "Bennett", "given": "Nicolas", "initials": "N"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J", "orcid": "0000-0001-8739-7896", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c2fb174ab842c8809900877de8c008.json"}}, {"family": "Dam", "given": "Tariq A", "initials": "TA"}, {"family": "Entjes", "given": "Robert", "initials": "R"}, {"family": "Rettig", "given": "Thijs C D", "initials": "TCD"}, {"family": "Dongelmans", "given": "Dave A", "initials": "DA"}, {"family": "Boelens", "given": "Age D", "initials": "AD"}, {"family": "Rigter", "given": "Sander", "initials": "S"}, {"family": "Hendriks", "given": "Stefaan H A", "initials": "SHA"}, {"family": "de Jong", "given": "Remko", "initials": "R"}, {"family": "Kamps", "given": "Marlijn J A", "initials": "MJA"}, {"family": "Peters", "given": "Marco", "initials": "M"}, {"family": "Karakus", "given": "Attila", "initials": "A"}, {"family": "Gommers", "given": "Diederik", "initials": "D"}, {"family": "Ramnarain", "given": "Dharmanand", "initials": "D"}, {"family": "Wils", "given": "Evert-Jan", "initials": "EJ"}, {"family": "Achterberg", "given": "Sefanja", "initials": "S"}, {"family": "Nowitzky", "given": "Ralph", "initials": "R"}, {"family": "van den Tempel", "given": "Walter", "initials": "W"}, {"family": "de Jager", "given": "Cornelis P C", "initials": "CPC"}, {"family": "Nooteboom", "given": "Fleur G C A", "initials": "FGCA"}, {"family": "Oostdijk", "given": "Evelien", "initials": "E"}, {"family": "Koetsier", "given": "Peter", "initials": "P"}, {"family": "Cornet", "given": "Alexander D", "initials": "AD"}, {"family": "Reidinga", "given": "Auke C", "initials": "AC"}, {"family": "de Ruijter", "given": "Wouter", "initials": "W"}, {"family": "Bosman", "given": "Rob J", "initials": "RJ"}, {"family": "Frenzel", "given": "Tim", "initials": "T"}, {"family": "Urlings-Strop", "given": "Louise C", "initials": "LC"}, {"family": "de Jong", "given": "Paul", "initials": "P"}, {"family": "Smit", "given": "Ellen G M", "initials": "EGM"}, {"family": "Cremer", "given": "Olaf L", "initials": "OL"}, {"family": "Mehagnoul-Schipper", "given": "D Jannet", "initials": "DJ"}, {"family": "Faber", "given": "Harald J", "initials": "HJ"}, {"family": "Lens", "given": "Judith", "initials": "J"}, {"family": "Brunnekreef", "given": "Gert B", "initials": "GB"}, {"family": "Festen-Spanjer", "given": "Barbara", "initials": "B"}, {"family": "Dormans", "given": "Tom", "initials": "T"}, {"family": "de Bruin", "given": "Daan P", "initials": "DP"}, {"family": "Lalisang", "given": "Robbert C A", "initials": "RCA"}, {"family": "Vonk", "given": "Sebastiaan J J", "initials": "SJJ"}, {"family": "Haan", "given": "Martin E", "initials": "ME"}, {"family": "Fleuren", "given": "Lucas M", "initials": "LM"}, {"family": "Thoral", "given": "Patrick J", "initials": "PJ"}, {"family": "Elbers", "given": "Paul W G", "initials": "PWG"}, {"family": "Bellomo", "given": "Rinaldo", "initials": "R"}], "type": "journal article", "published": "2021-10-08", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172"}, "abstract": "The prediction of in-hospital mortality for ICU patients with COVID-19 is fundamental to treatment and resource allocation. The main purpose was to develop an easily implemented score for such prediction.\n\nThis was an observational, multicenter, development and validation study on a national critical care dataset of COVID-19 patients. A systematic literature review was performed to determine variables possibly important for COVID-19 mortality prediction. Using a logistic multivariable model with a LASSO penalty, we developed the Rapid Evaluation of Coronavirus Illness Severity (RECOILS) score and compared its performance against published scores.\n\nOur development (validation) cohort consisted of 1480 (937) adult patients from 14 (11) Dutch ICUs admitted between March 2020 and April 2021. Median age was 65 (65) years, 31% (26%) died in hospital, 74% (72%) were males, average length of ICU stay was 7.83 (10.25) days and average length of hospital stay was 15.90 (19.92) days. Age, platelets, PaO2/FiO2 ratio, pH, blood urea nitrogen, temperature, PaCO2, Glasgow Coma Scale (GCS) score measured within +/- 24 hours of ICU admission were used to develop the score. The AUROC of RECOILS score was 0.75 (CI 0.71-0.78) which was higher than that of any previously reported predictive scores (0.68 (CI 0.64-0.71), 0.61 (CI 0.58-0.66), 0.67 (CI 0.63-0.70), 0.70 (CI 0.67-0.74) for ISARIC 4C Mortality Score, SOFA, SAPS-III, and age, respectively).\n\nUsing a large dataset from multiple Dutch ICUs, we developed a predictive score for mortality of COVID-19 patients admitted to ICU, which outperformed other predictive scores reported so far.", "doi": "10.1111/aas.13991", "pmid": "34622441", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:07:16.357Z", "modified": "2021-10-10T15:07:16.414Z"}, {"entity": "publication", "iuid": "77afdca8913f4abc8f52e71eb7efce65", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/77afdca8913f4abc8f52e71eb7efce65.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/77afdca8913f4abc8f52e71eb7efce65"}}, "title": "Impacts of mild COVID-19 on elevated use of primary and specialist health care services: A nationwide register study from Norway.", "authors": [{"family": "Skyrud", "given": "Katrine Damgaard", "initials": "KD", "orcid": "0000-0001-7504-9253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa7b45c41c544ba098093febd55117c8.json"}}, {"family": "Hern\u00e6s", "given": "Kjersti Helene", "initials": "KH"}, {"family": "Telle", "given": "Kjetil Elias", "initials": "KE"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2021-10-08", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0257926", "issn-l": "1932-6203"}, "abstract": "To explore the temporal impact of mild COVID-19 on need for primary and specialist health care services.\n\nIn all adults (\u226520 years) tested for SARS-CoV-2 in Norway March 1st 2020 to February 1st 2021 (N = 1 401 922), we contrasted the monthly all-cause health care use before and up to 6 months after the test (% relative difference), for patients with a positive test for SARS-CoV-2 (non-hospitalization, i.e. mild COVID-19) and patients with a negative test (no COVID-19).\n\nWe found a substantial short-term elevation in primary care use in all age groups, with men generally having a higher relative increase (men 20-44 years: 522%, 95%CI = 509-535, 45-69 years: 439%, 95%CI = 426-452, \u226570 years: 199%, 95%CI = 180-218) than women (20-44 years: 342, 95%CI = 334-350, 45-69 years = 375, 95%CI = 365-385, \u226570 years: 156%, 95%CI = 141-171) at 1 month following positive test. At 2 months, this sex difference was less pronounced, with a (20-44 years: 21%, 95%CI = 13-29, 45-69 years = 38%, 95%CI = 30-46, \u226570 years: 15%, 95%CI = 3-28) increase in primary care use for men, and a (20-44 years: 30%, 95%CI = 24-36, 45-69 years = 57%, 95%CI = 50-64, \u226570 years: 14%, 95%CI = 4-24) increase for women. At 3 months after test, only women aged 45-70 years still had an increased primary care use (14%, 95%CI = 7-20). The increase was due to respiratory- and general/unspecified conditions. We observed no long-term (4-6 months) elevation in primary care use, and no elevation in specialist care use.\n\nMild COVID-19 gives an elevated need for primary care that vanishes 2-3 months after positive test. Middle-aged women had the most prolonged increased primary care use.", "doi": "10.1371/journal.pone.0257926", "pmid": "34624023", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-20514"}], "notes": [], "created": "2021-10-10T15:04:07.839Z", "modified": "2021-10-10T15:04:07.870Z"}, {"entity": "publication", "iuid": "e63147ae2ad5461fab8c3c22dd457a15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e63147ae2ad5461fab8c3c22dd457a15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e63147ae2ad5461fab8c3c22dd457a15"}}, "title": "Depression and anxiety disorders during the COVID-19 pandemic: knowns and unknowns.", "authors": [{"family": "Taquet", "given": "Maxime", "initials": "M"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}, {"family": "Harrison", "given": "Paul J", "initials": "PJ"}], "type": "journal article", "published": "2021-10-08", "journal": {"title": "Lancet", "issn": "1474-547X", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(21)02221-2", "pmid": "34634251", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)02221-2"}], "notes": [], "created": "2021-10-21T05:40:59.740Z", "modified": "2021-10-21T05:40:59.753Z"}, {"entity": "publication", "iuid": "f1d72e38164244329f331bc86c438bb8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1d72e38164244329f331bc86c438bb8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1d72e38164244329f331bc86c438bb8"}}, "title": "Risk and protective factors, stressors, and symptoms of adjustment disorder during the COVID-19 pandemic - First results of the ESTSS COVID-19 pan-European ADJUST study.", "authors": [{"family": "Lotzin", "given": "Annett", "initials": "A", "orcid": "0000-0002-2834-8047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/414bdffc7c514b68ad7b342cd97121fa.json"}}, {"family": "Krause", "given": "Linda", "initials": "L"}, {"family": "Acquarini", "given": "Elena", "initials": "E"}, {"family": "Ajdukovic", "given": "Dean", "initials": "D"}, {"family": "Ardino", "given": "Vittoria", "initials": "V"}, {"family": "Arnberg", "given": "Filip", "initials": "F", "orcid": "0000-0002-1317-2093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b82329ec9cc545ee98bf639481323581.json"}}, {"family": "B\u00f6ttche", "given": "Maria", "initials": "M"}, {"family": "Bragesj\u00f6", "given": "Maria", "initials": "M", "orcid": "0000-0003-2246-3842", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/abec108719f641bf9fe4d0b13d62e327.json"}}, {"family": "Dragan", "given": "Ma\u0142gorzata", "initials": "M", "orcid": "0000-0001-8221-2012", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6abe40fed044419da5ab35e198fbacf8.json"}}, {"family": "Figueiredo-Braga", "given": "Margarida", "initials": "M"}, {"family": "Gelezelyte", "given": "Odeta", "initials": "O"}, {"family": "Grajewski", "given": "Piotr", "initials": "P"}, {"family": "Anastassiou-Hadjicharalambous", "given": "Xenia", "initials": "X"}, {"family": "Javakhishvili", "given": "Jana Darejan", "initials": "JD"}, {"family": "Kazlauskas", "given": "Evaldas", "initials": "E", "orcid": "0000-0002-6654-6220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/325ffed05ee04a7fb3aefc3dd9e168e1.json"}}, {"family": "Lenferink", "given": "Lonneke", "initials": "L", "orcid": "0000-0003-1329-6413", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d757067e8b284b5eac977e0dfd923967.json"}}, {"family": "Lioupi", "given": "Chrysanthi", "initials": "C"}, {"family": "Lueger-Schuster", "given": "Brigitte", "initials": "B", "orcid": "0000-0003-0784-8437", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e96be3831b3e43ed9980bdf9f8853899.json"}}, {"family": "Tsiskarishvili", "given": "Lela", "initials": "L"}, {"family": "Mooren", "given": "Trudy", "initials": "T"}, {"family": "Sales", "given": "Luisa", "initials": "L"}, {"family": "Stevanovic", "given": "Aleksandra", "initials": "A"}, {"family": "Zrnic", "given": "Irina", "initials": "I"}, {"family": "Sch\u00e4fer", "given": "Ingo", "initials": "I", "orcid": "0000-0002-9711-3559", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a082abe10d34bbbb8d3461dbf058cfd.json"}}], "type": "journal article", "published": "2021-10-07", "journal": {"title": "Eur J Psychotraumatol", "issn": "2000-8066", "volume": "12", "issue": "1", "pages": "1964197", "issn-l": null}, "abstract": "The COVID-19 pandemic exposes individuals to multiple stressors, such as quarantine, physical distancing, job loss, risk of infection, and loss of loved ones. Such a complex array of stressors potentially lead to symptoms of adjustment disorder.\n\nThis cross-sectional exploratory study examined relationships between risk and protective factors, stressors, and symptoms of adjustment disorder during the first year of the COVID-19 pandemic.\n\nData from the first wave of the European Society of Traumatic Stress Studies (ESTSS) longitudinal ADJUST Study were used. N = 15,563 participants aged 18 years and above were recruited in eleven countries (Austria, Croatia, Georgia, Germany, Greece, Italy, Lithuania, the Netherlands, Poland, Portugal, and Sweden) from June to November 2020. Associations between risk and protective factors (e.g. gender, diagnosis of a mental health disorder), stressors (e.g. fear of infection, restricted face-to-face contact), and symptoms of adjustment disorder (ADNM-8) were examined using multivariate linear regression.\n\nThe prevalence of self-reported probable adjustment disorder was 18.2%. Risk factors associated with higher levels of symptoms of adjustment disorder were female gender, older age, being at risk for severe COVID-19 illness, poorer general health status, current or previous trauma exposure, a current or previous mental health disorder, and longer exposure to COVID-19 news. Protective factors related to lower levels of symptoms of adjustment disorder were higher income, being retired, and having more face-to-face contact with loved ones or friends. Pandemic-related stressors associated with higher levels of symptoms of adjustment disorder included fear of infection, governmental crisis management, restricted social contact, work-related problems, restricted activity, and difficult housing conditions.\n\nWe identified stressors, risk, and protective factors that may help identify individuals at higher risk for adjustment disorder.", "doi": "10.1080/20008198.2021.1964197", "pmid": "34992755", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "1964197"}, {"db": "pmc", "key": "PMC8725769"}], "notes": [], "created": "2022-01-10T15:31:26.902Z", "modified": "2022-01-10T15:31:28.538Z"}, {"entity": "publication", "iuid": "5327d5834c684edc9a2a761b3d58d128", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5327d5834c684edc9a2a761b3d58d128.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5327d5834c684edc9a2a761b3d58d128"}}, "title": "Reduced ability to produce reflex-evoked neurogenic inflammation, a sign of decreased defense against COVID-19 infection?", "authors": [{"family": "Malm", "given": "Lars", "initials": "L", "orcid": "0000-0002-3408-4455", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee058659e4c64f6db787c4b9f19eec6c.json"}}], "type": "journal article", "published": "2021-10-07", "journal": {"title": "Skin Res Technol", "issn": "1600-0846", "issn-l": null}, "abstract": "A histamine skin prick test (SPT) generally evokes a wheal and a flare. The present study was initiated by an observation that histamine did not evoke a flare around a wheal in the skin of an 86-year-old man. Could that be of relevance to the findings that old men are prone to a more severe COVD-19 infection with a higher mortality than young ones?\n\nHistamine SPT was performed on the forearm of six old men, all above the age of 80. The skin reactions were photographed from above and from the side. The photographs taken from above were treated in a computer with LYYN, a program that increases color differences. With the help of ImageJ (NIH), the size relation between flare and wheal was calculated. On the photographs, taken as side views, areas, heights, and diameters of wheals were measured. Controls consisted of three groups of younger people.\n\nAmong the old men, no or only a small flare was seen. All the controls had prominent flares. Histamine SPT evoked small wheals in the group of old men as compared to young men.\n\nReduced neurogenic inflammation evoked by histamine from mast cells in blood and tissue may reduce the defense against COVID-19 infection.", "doi": "10.1111/srt.13089", "pmid": "34618975", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:24:02.582Z", "modified": "2021-10-10T15:24:12.373Z"}, {"entity": "publication", "iuid": "f6c40f5a5c124c73adee6ac3acba4ad1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6c40f5a5c124c73adee6ac3acba4ad1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6c40f5a5c124c73adee6ac3acba4ad1"}}, "title": "Quantifying the impacts of human mobility restriction on the spread of coronavirus disease 2019: an empirical analysis from 344 cities of China.", "authors": [{"family": "Tan", "given": "Jing", "initials": "J"}, {"family": "Zhao", "given": "Shao-Yang", "initials": "SY"}, {"family": "Xiong", "given": "Yi-Quan", "initials": "YQ"}, {"family": "Liu", "given": "Chun-Rong", "initials": "CR"}, {"family": "Huang", "given": "Shi-Yao", "initials": "SY"}, {"family": "Lu", "given": "Xin", "initials": "X"}, {"family": "Thabane", "given": "Lehana", "initials": "L"}, {"family": "Xie", "given": "Feng", "initials": "F"}, {"family": "Sun", "given": "Xin", "initials": "X"}, {"family": "Li", "given": "Wei-Min", "initials": "WM"}], "type": "journal article", "published": "2021-10-07", "journal": {"title": "Chin Med J (Engl)", "issn": "2542-5641", "volume": "134", "issue": "20", "pages": "2438-2446", "issn-l": null}, "abstract": "Since the outbreak of coronavirus disease 2019 (COVID-19), human mobility restriction measures have raised controversies, partly because of the inconsistent findings. An empirical study is promptly needed to reliably assess the causal effects of the mobility restriction. The purpose of this study was to quantify the causal effects of human mobility restriction on the spread of COVID-19.\n\nOur study applied the difference-in-difference (DID) model to assess the declines of population mobility at the city level, and used the log-log regression model to examine the effects of population mobility declines on the disease spread measured by cumulative or new cases of COVID-19 over time after adjusting for confounders.\n\nThe DID model showed that a continual expansion of the relative declines over time in 2020. After 4 weeks, population mobility declined by -54.81% (interquartile range, -65.50% to -43.56%). The accrued population mobility declines were associated with the significant reduction of cumulative COVID-19 cases throughout 6 weeks (ie, 1% decline of population mobility was associated with 0.72% [95% CI: 0.50%-0.93%] reduction of cumulative cases for 1 week, 1.42% 2 weeks, 1.69% 3 weeks, 1.72% 4 weeks, 1.64% 5 weeks, and 1.52% 6 weeks). The impact on the weekly new cases seemed greater in the first 4 weeks but faded thereafter. The effects on cumulative cases differed by cities of different population sizes, with greater effects seen in larger cities.\n\nPersistent population mobility restrictions are well deserved. Implementation of mobility restrictions in major cities with large population sizes may be even more important.", "doi": "10.1097/CM9.0000000000001763", "pmid": "34620748", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8654447"}, {"db": "pii", "key": "00029330-202110200-00009"}], "notes": [], "created": "2021-10-10T15:09:25.592Z", "modified": "2023-06-19T15:32:35.419Z"}, {"entity": "publication", "iuid": "588404bd37a041b58b8b940a9211a7a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/588404bd37a041b58b8b940a9211a7a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/588404bd37a041b58b8b940a9211a7a2"}}, "title": "Monetary incentives increase COVID-19 vaccinations.", "authors": [{"family": "Campos-Mercade", "given": "Pol", "initials": "P", "orcid": "0000-0002-7396-6514", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f4066be7689442009ba93911c0ec8771.json"}}, {"family": "Meier", "given": "Armando N", "initials": "AN", "orcid": "0000-0001-7977-8875", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3742dc32640c487eaee5493c1ae3432c.json"}}, {"family": "Schneider", "given": "Florian H", "initials": "FH", "orcid": "0000-0002-8406-2756", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76b238f01e6749bab5aefb7308ba056d.json"}}, {"family": "Meier", "given": "Stephan", "initials": "S", "orcid": "0000-0001-6726-9731", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d19cff065b54dea9974baeff383b788.json"}}, {"family": "Pope", "given": "Devin", "initials": "D", "orcid": "0000-0002-6567-9654", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2c1fb2cb5704cd08f6a919b071e4c4e.json"}}, {"family": "Wengstr\u00f6m", "given": "Erik", "initials": "E", "orcid": "0000-0002-1414-9055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e53ebfb55494b95911dcac8ad5e2a8b.json"}}], "type": "journal article", "published": "2021-10-07", "journal": {"title": "Science", "issn": "1095-9203", "pages": "eabm0475", "issn-l": "0036-8075"}, "abstract": "[Figure: see text].", "doi": "10.1126/science.abm0475", "pmid": "34618594", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:24:52.231Z", "modified": "2021-10-10T15:24:52.385Z"}, {"entity": "publication", "iuid": "38c7f28743fe4af18264ee231be1f617", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38c7f28743fe4af18264ee231be1f617.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38c7f28743fe4af18264ee231be1f617"}}, "title": "Cardiovascular Magnetic Resonance for Patients With COVID-19.", "authors": [{"family": "Petersen", "given": "Steffen E", "initials": "SE"}, {"family": "Friedrich", "given": "Matthias G", "initials": "MG"}, {"family": "Leiner", "given": "Tim", "initials": "T"}, {"family": "Elias", "given": "Matthew D", "initials": "MD"}, {"family": "Ferreira", "given": "Vanessa M", "initials": "VM"}, {"family": "Fenski", "given": "Maximilian", "initials": "M"}, {"family": "Flamm", "given": "Scott D", "initials": "SD"}, {"family": "Fogel", "given": "Mark", "initials": "M"}, {"family": "Garg", "given": "Ria", "initials": "R"}, {"family": "Halushka", "given": "Marc K", "initials": "MK"}, {"family": "Hays", "given": "Allison G", "initials": "AG"}, {"family": "Kawel-Boehm", "given": "Nadine", "initials": "N"}, {"family": "Kramer", "given": "Christopher M", "initials": "CM"}, {"family": "Nagel", "given": "Eike", "initials": "E"}, {"family": "Ntusi", "given": "Ntobeko A B", "initials": "NAB"}, {"family": "Ostenfeld", "given": "Ellen", "initials": "E"}, {"family": "Pennell", "given": "Dudley J", "initials": "DJ"}, {"family": "Raisi-Estabragh", "given": "Zahra", "initials": "Z"}, {"family": "Reeder", "given": "Scott B", "initials": "SB"}, {"family": "Rochitte", "given": "Carlos E", "initials": "CE"}, {"family": "Starekova", "given": "Jitka", "initials": "J"}, {"family": "Such\u00e1", "given": "Dominika", "initials": "D"}, {"family": "Tao", "given": "Qian", "initials": "Q"}, {"family": "Schulz-Menger", "given": "Jeanette", "initials": "J"}, {"family": "Bluemke", "given": "David A", "initials": "DA"}], "type": "journal article", "published": "2021-10-07", "journal": {"title": "JACC Cardiovasc Imaging", "issn": "1876-7591", "issn-l": null}, "abstract": "COVID-19 is associated with myocardial injury caused by ischemia, inflammation, or myocarditis. Cardiovascular magnetic resonance (CMR) is the noninvasive reference standard for cardiac function, structure, and tissue composition. CMR is a potentially valuable diagnostic tool in patients with COVID-19 presenting with myocardial injury and evidence of cardiac dysfunction. Although COVID-19-related myocarditis is likely infrequent, COVID-19-related cardiovascular histopathology findings have been reported in up to 48% of patients, raising the concern for long-term myocardial injury. Studies to date report CMR abnormalities in 26% to 60% of hospitalized patients who have recovered from COVID-19, including functional impairment, myocardial tissue abnormalities, late gadolinium enhancement, or pericardial abnormalities. In athletes post-COVID-19, CMR has detected myocarditis-like abnormalities. In children, multisystem inflammatory syndrome may occur 2 to 6 weeks after infection; associated myocarditis and coronary artery aneurysms are evaluable by CMR. At this time, our understanding of COVID-19-related cardiovascular involvement is incomplete, and multiple studies are planned to evaluate patients with COVID-19 using CMR. In this review, we summarize existing studies of CMR for patients with COVID-19 and present ongoing research. We also provide recommendations for clinical use of CMR for patients with acute symptoms or who are recovering from COVID-19.", "doi": "10.1016/j.jcmg.2021.08.021", "pmid": "34656482", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1936-878X(21)00688-4"}], "notes": [], "created": "2021-10-21T05:03:00.026Z", "modified": "2021-10-21T05:03:00.039Z"}, {"entity": "publication", "iuid": "41da54b6251142b5a37a2d2c195e3744", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41da54b6251142b5a37a2d2c195e3744.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41da54b6251142b5a37a2d2c195e3744"}}, "title": "COVID-19 and the ageing workforce: global perspectives on needs and solutions across 15 countries.", "authors": [{"family": "Pit", "given": "Sabrina", "initials": "S", "orcid": "0000-0003-2410-0703", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10d28d10de7246d892a63c541aeb4be0.json"}}, {"family": "Fisk", "given": "Malcolm", "initials": "M"}, {"family": "Freihaut", "given": "Winona", "initials": "W"}, {"family": "Akintunde", "given": "Fashola", "initials": "F"}, {"family": "Aloko", "given": "Bamidele", "initials": "B"}, {"family": "Berge", "given": "Britta", "initials": "B"}, {"family": "Burmeister", "given": "Anne", "initials": "A"}, {"family": "Ciac\u00e2ru", "given": "Adriana", "initials": "A"}, {"family": "Deller", "given": "J\u00fcrgen", "initials": "J"}, {"family": "Dulmage", "given": "Rae", "initials": "R"}, {"family": "Han", "given": "Tae Hwa", "initials": "TH"}, {"family": "Hao", "given": "Qiang", "initials": "Q"}, {"family": "Honeyman", "given": "Peter", "initials": "P"}, {"family": "Huber", "given": "Peter C", "initials": "PC"}, {"family": "Linner", "given": "Thomas", "initials": "T"}, {"family": "Lundberg", "given": "Stefan", "initials": "S"}, {"family": "Nwamara", "given": "Mofoluwaso", "initials": "M"}, {"family": "Punpuing", "given": "Kamolpun", "initials": "K"}, {"family": "Schramm", "given": "Jennifer", "initials": "J"}, {"family": "Yamada", "given": "Hajime", "initials": "H"}, {"family": "Yap", "given": "Jason C H", "initials": "JCH"}], "type": "letter", "published": "2021-10-07", "journal": {"title": "Int J Equity Health", "issn": "1475-9276", "volume": "20", "issue": "1", "pages": "221", "issn-l": null}, "abstract": "COVID-19 has a direct impact on the employment of older people. This adds to the challenge of ageism. The World Health Organization has started a worldwide campaign to combat ageism and has called for more research and evidence-based strategies that have the potential to be scaled up. This study specifically aims to identify solutions to combat the adverse effects of COVID-19 on the global ageing workforce.\n\nWe present 15 case studies from different countries and report on what those countries are doing or not doing to address the impact of COVID-19 on ageing workers.\n\nWe provide examples of how COVID-19 influences older people's ability to work and stay healthy, and offer case studies of what governments, organizations or individuals can do to help ensure older people can obtain, maintain and, potentially, expand their current work. Case studies come from Australia, Austria, Canada, China, Germany, Israel, Japan, Nigeria, Romania, Singapore, Sweden, South Korea, Thailand, United Kingdom (UK), and the United States (US). Across the countries, the impact of COVID-19 on older workers is shown as widening inequalities. A particular challenge has arisen because of a large proportion of older people, often with limited education and working in the informal sector within rural areas, e.g. in Nigeria, Thailand and China. Remedies to the particular disadvantage experienced by older workers in the context of COVID are presented. These range from funding support to encouraging business continuity, innovative product and service developments, community action, new business models and localized, national and international actions. The case studies can be seen as frequently fitting within strategies that have been proven to work in reducing ageism within the workplace. They include policy and laws that have increased benefits to workers during lockdowns (most countries); educational activities such as coaching seniorpreneurship (e,g, Australia); intergenerational contact interventions such as younger Thai people who moved back to rural areas and sharing their digital knowledge with older people and where older people reciprocate by teaching the younger people farming knowledge.\n\nGlobal sharing of this knowledge among international, national and local governments and organizations, businesses, policy makers and health and human resources experts will further understanding of the issues that are faced by older workers. This will facilitate the replication or scalability of solutions as called for in the WHO call to combat ageism in 2021. We suggest that policy makers, business owners, researchers and international organisations build on the case studies by investing in evidence-based strategies to create inclusive workplaces. Such action will thus help to challenge ageism, reduce inequity, improve business continuity and add to the quality of life of older workers.", "doi": "10.1186/s12939-021-01552-w", "pmid": "34620164", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12939-021-01552-w"}], "notes": [], "created": "2021-10-10T15:11:05.307Z", "modified": "2021-10-10T15:11:19.877Z"}, {"entity": "publication", "iuid": "d6b5dfe0a80a42fda6b2fec7020b8aa9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d6b5dfe0a80a42fda6b2fec7020b8aa9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d6b5dfe0a80a42fda6b2fec7020b8aa9"}}, "title": "Antigen receptor stimulation drives selection against pathogenic mtDNA variants that dysregulate lymphocyte responses", "authors": [{"family": "Zhang", "given": "Jingdian", "initials": "J", "orcid": "0000-0002-5685-8386", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/139b5809061346d39e002c77816fde6a.json"}}, {"family": "Koolmeister", "given": "Camilla", "initials": "C", "orcid": "0000-0002-4052-3442", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4297e6da55f4b3c8fd076fa713feb10.json"}}, {"family": "Han", "given": "Jinming", "initials": "J", "orcid": "0000-0002-6084-3275", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb80d9babf4c44ba9a253e9d4fdd0ce2.json"}}, {"family": "Filograna", "given": "Roberta", "initials": "R", "orcid": "0000-0002-6581-9426", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7a885a6fd994c0fb9be5380566db317.json"}}, {"family": "Hanke", "given": "Leo", "initials": "L", "orcid": "0000-0001-5514-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a35f10de4f2e4aee98278f6ab845613d.json"}}, {"family": "\u00c0dori", "given": "Monika", "initials": "M"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ", "orcid": "0000-0002-0227-5636", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a612a313d5874131ba64d9811a5d4a08.json"}}, {"family": "Teifel", "given": "Sina", "initials": "S"}, {"family": "Liu", "given": "Yong", "initials": "Y"}, {"family": "Harris", "given": "Robert A", "initials": "RA", "orcid": "0000-0003-4990-509X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/281bc302a3134c2288944689057586b0.json"}}, {"family": "Murrell", "given": "Ben", "initials": "B", "orcid": "0000-0002-0393-4445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60dac9ecf84d4eb3b90fb4ee1298bc52.json"}}, {"family": "Mcinerney", "given": "Gerald", "initials": "G", "orcid": "0000-0003-2257-7241", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7770437d845444a8a07865bf5b62fab0.json"}}, {"family": "Aoun", "given": "Mike", "initials": "M", "orcid": "0000-0002-7814-3787", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11060fd375054a4fa3038f0a46ad5c94.json"}}, {"family": "B\u00e4ckdahl", "given": "Liselotte", "initials": "L"}, {"family": "Holmdahl", "given": "Rikard", "initials": "R", "orcid": "0000-0002-4969-2576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/583b21b385a747a5a75695c08847b61b.json"}}, {"family": "Pekalski", "given": "Marcin", "initials": "M", "orcid": "0000-0001-7623-4370", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d12f48c2a2d4c6ea50af0f51e90c83b.json"}}, {"family": "Wedell", "given": "Anna", "initials": "A", "orcid": "0000-0002-2612-6301", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a2177a737cb4fd8b49af5af451a7a3f.json"}}, {"family": "Engvall", "given": "Martin", "initials": "M", "orcid": "0000-0002-8339-3545", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4eb7b09c59d48579d33248024846c16.json"}}, {"family": "Wredenberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-2500-6121", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58d21281196345539d7c55bc4e778c24.json"}}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB", "orcid": "0000-0001-7255-9047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/891aa9ca3f604b7396a14d65a33c2187.json"}}, {"family": "Dopico", "given": "Xaquin Castro", "initials": "XC", "orcid": "0000-0002-9005-6774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/354c91b234fd4a039f85c13e7e4209c1.json"}}, {"family": "Rorbach", "given": "Joanna", "initials": "J", "orcid": "0000-0002-2891-2840", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ddfd02a56dc4c43ac6e01c113c19874.json"}}], "type": "posted-content", "published": "2021-10-07", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.10.05.21264464", "pmid": null, "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null, "Funder: H2020": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:42:30.709Z", "modified": "2021-10-26T18:42:31.160Z"}, {"entity": "publication", "iuid": "e441333fa3164d2f8f0112b4397e2684", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e441333fa3164d2f8f0112b4397e2684.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e441333fa3164d2f8f0112b4397e2684"}}, "title": "Androgen deprivation therapy and excess mortality in men with prostate cancer during the initial phase of the COVID-19 pandemic.", "authors": [{"family": "Gedeborg", "given": "Rolf", "initials": "R", "orcid": "0000-0002-8850-7863", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/234ef51ed7854efb8bbadc3ce35bf7d9.json"}}, {"family": "Styrke", "given": "Johan", "initials": "J"}, {"family": "Loeb", "given": "Stacy", "initials": "S"}, {"family": "Garmo", "given": "Hans", "initials": "H"}, {"family": "Stattin", "given": "P\u00e4r", "initials": "P", "orcid": "0000-0002-8306-0687", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/504d868e215c41ab8a75cb2e6cd289b8.json"}}], "type": "journal article", "published": "2021-10-07", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0255966", "issn-l": "1932-6203"}, "abstract": "Men have a higher risk of death from COVID-19 than women and androgens facilitate entrance of the SARS-CoV-2 virus into respiratory epithelial cells. Thus, androgen deprivation therapy may reduce infection rates and improve outcomes for COVID-19. In the spring of 2020, Sweden was highly affected by COVID-19. The aim was to estimate the impact of androgen deprivation therapy on mortality from COVID-19 in men with prevalent prostate cancer by comparing all-cause mortality in the spring of 2020 to that in previous years.\n\nUsing the Prostate Cancer data Base Sweden all men with prostate cancer on March 1 each year in 2015-2020 were followed until June 30 the same year. Exposure to androgen deprivation therapy was ascertained from filled prescriptions for bicalutamide monotherapy, gonadotropin-releasing hormone agonists (GnRH), or bilateral orchidectomy.\n\nA total of 9,822 men died in March-June in the years 2015-2020, of whom 5,034 men were on androgen deprivation therapy. There was an excess mortality in 2020 vs previous years in all men. The crude relative mortality rate ratio for 2020 vs 2015-2019 was 0.93 (95% confidence interval (CI) 0.83 to 1.04) in men on GnRH, and 0.90 (95% CI 0.78 to 1.05) in men on bicalutamide monotherapy. After multivariable adjustment these ratios were attenuated to 1.00 (95% CI 0.89 to 1.12) and 0.97 (95% CI 0.84 to 1.12), respectively. When restricting the analysis to the regions with the highest incidence of COVID-19 or to the time period between 2 April to 10 June when mortality in 2020 was increased >30% compared to previous years, the results were similar to the main analysis.\n\nIn this large national population-based cohort of men with prevalent prostate cancer, there was no clear evidence in support for an effect of androgen deprivation therapy on COVID-19 mortality.", "doi": "10.1371/journal.pone.0255966", "pmid": "34618806", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-04843"}], "notes": [], "created": "2021-10-10T15:24:32.122Z", "modified": "2021-10-10T15:24:32.184Z"}, {"entity": "publication", "iuid": "6366e1e82162434eb530528760477605", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6366e1e82162434eb530528760477605.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6366e1e82162434eb530528760477605"}}, "title": "A cell-free high throughput assay for assessment of SARS-CoV-2 neutralizing antibodies.", "authors": [{"family": "Mravinacova", "given": "Sara", "initials": "S"}, {"family": "J\u00f6nsson", "given": "Malin", "initials": "M"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Yousef", "given": "Jamil", "initials": "J"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Tegel", "given": "Hanna", "initials": "H"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Hober", "given": "Sophia", "initials": "S"}], "type": "journal article", "published": "2021-10-07", "journal": {"title": "N Biotechnol", "issn": "1876-4347", "issn-l": null, "volume": "66", "issue": null, "pages": "46-52"}, "abstract": "Highly accurate serological tests are key to assessing the prevalence of SARS-CoV-2 antibodies and the level of immunity in the population. This is important to predict the current and future status of the pandemic. With the recent emergence of new and more infectious SARS-CoV-2 variants, assays allowing for high throughput analysis of antibodies able to neutralize SARS-CoV-2 become even more important. Here, we report the development and validation of a robust, high throughput method, which enables the assessment of antibodies inhibiting the binding between the SARS-CoV-2 spike protein and angiotensin converting enzyme 2 (ACE2). The assay uses recombinantly produced spike-f and ACE2 and is performed in a bead array format, which allows analysis of up to 384 samples in parallel per instrument over seven hours, demanding only one hour of manual handling. The method is compared to a microneutralization assay utilising live SARS-CoV-2 and is shown to deliver highly correlating data. Further, a comparison with a serological method that measures all antibodies recognizing the spike protein shows that this type of assessment provides important insights into the neutralizing efficiency of the antibodies, especially for individuals with low antibody levels. This method can be an important and valuable tool for large-scale assessment of antibody-based neutralization, including neutralization of new spike variants that might emerge.", "doi": "10.1016/j.nbt.2021.10.002", "pmid": "34628049", "labels": {"Research Area: High-throughput and high-content serology": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Research Area: Host cell systems biology and targets": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: H2020": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1871-6784(21)00091-1"}, {"db": "pmc", "key": "PMC8495044"}], "notes": [], "created": "2021-10-11T17:45:54.123Z", "modified": "2021-11-18T16:29:35.546Z"}, {"entity": "publication", "iuid": "4a866576db52433b8a76b49766800900", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4a866576db52433b8a76b49766800900.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4a866576db52433b8a76b49766800900"}}, "title": "Social Jetlag Changes During the COVID-19 Pandemic as a Predictor of Insomnia - A Multi-National Survey Study.", "authors": [{"family": "Brand\u00e3o", "given": "Luiz Eduardo Mateus", "initials": "LEM", "orcid": "0000-0002-8672-7870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5d4c5e8bc704f2cb500e28e657ea315.json"}}, {"family": "Martikainen", "given": "Teemu", "initials": "T", "orcid": "0000-0003-2399-5138", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f163f4fee7514093a8fa354b45a137c8.json"}}, {"family": "Merikanto", "given": "Ilona", "initials": "I", "orcid": "0000-0002-1222-6678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50ed32f3146e4c0aa13e934d46eeb4af.json"}}, {"family": "Holzinger", "given": "Brigitte", "initials": "B", "orcid": "0000-0001-5385-4091", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/179fc564b66746d2a981082e5411d762.json"}}, {"family": "Morin", "given": "Charles M", "initials": "CM", "orcid": "0000-0002-8649-8895", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd42cb2cf7194992b7c06fac723e6ceb.json"}}, {"family": "Espie", "given": "Colin A", "initials": "CA", "orcid": "0000-0002-1294-8734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60482d2788b1405fb87b71442f703529.json"}}, {"family": "Bolstad", "given": "Courtney J", "initials": "CJ", "orcid": "0000-0003-2297-2778", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f47da3539dc4c0c95abe747ddd2fb55.json"}}, {"family": "Leger", "given": "Damien", "initials": "D", "orcid": "0000-0003-1168-480X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2cf778dd1ed9418bb0c182347f1a0355.json"}}, {"family": "Chung", "given": "Frances", "initials": "F", "orcid": "0000-0001-9576-3606", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed55f48b6d8e400b8fd2c591a738260a.json"}}, {"family": "Plazzi", "given": "Giuseppe", "initials": "G", "orcid": "0000-0002-1051-0472", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1a913222e004ad088535b1a251c8b7a.json"}}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y", "orcid": "0000-0003-0683-6506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/630f66dea3ce4ff2afe3c46f7827355b.json"}}, {"family": "Matsui", "given": "Kentaro", "initials": "K", "orcid": "0000-0003-4538-5381", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9e5535bdd6f48d79c36d3170c28f67c.json"}}, {"family": "De Gennaro", "given": "Luigi", "initials": "L", "orcid": "0000-0003-3613-6631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e700e607f114414dba66aa366e3158b6.json"}}, {"family": "Sieminski", "given": "Mariusz", "initials": "M", "orcid": "0000-0001-8219-2912", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f92e908212f4d859cb42261a43c47c2.json"}}, {"family": "Nadorff", "given": "Michael R", "initials": "MR"}, {"family": "Chan", "given": "Ngan Yin", "initials": "NY", "orcid": "0000-0002-3009-3565", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0c796d43e5947b6890322603ad7a318.json"}}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK", "orcid": "0000-0002-5745-5474", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bbe4815f36d48959f5e81a5cf650088.json"}}, {"family": "Mota-Rolim", "given": "S\u00e9rgio Arthuro", "initials": "SA", "orcid": "0000-0003-0196-5421", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/345ba991c90a4c8689f51366dfbeba54.json"}}, {"family": "Inoue", "given": "Yuichi", "initials": "Y", "orcid": "0000-0001-7414-9017", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cd6cb8358f04e8c9c11e1ecd0f03a58.json"}}, {"family": "Partinen", "given": "Markku", "initials": "M", "orcid": "0000-0002-8182-9368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7920bcc4716848f7bd1cb89c8bdd0d5a.json"}}, {"family": "Benedict", "given": "Christian", "initials": "C", "orcid": "0000-0002-8911-4068", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a61aee14ada46ce968c40c652ac72df.json"}}, {"family": "Bjorvatn", "given": "Bjorn", "initials": "B", "orcid": "0000-0001-7051-745X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b72d97a35fa4590b5d05f0fd3524f2e.json"}}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-9052-8372", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36e153ded210463a84153370c34fa843.json"}}], "type": "journal article", "published": "2021-10-06", "journal": {"title": "Nat Sci Sleep", "issn": "1179-1608", "volume": "13", "pages": "1711-1722", "issn-l": null}, "abstract": "Lifestyle and work habits have been drastically altered by restrictions due to the COVID-19 pandemic. Whether the associated changes in sleep timing modulate the risk of suffering from symptoms of insomnia, the most prevalent sleep disorder, is however incompletely understood. Here, we evaluate the association between the early pandemic-associated change in 1) the magnitude of social jetlag (SJL) - ie, the difference between sleep timing on working vs free days - and 2) symptoms of insomnia.\n\nA total of 14,968 anonymous participants (mean age: 40 years; 64% females) responded to a standardized internet-based survey distributed across 14 countries. Using logistic multivariate regression, we examined the association between the degree of social jetlag and symptoms of insomnia, controlling for important confounders like social restriction extension, country specific COVID-19 severity and psychological distress, for example.\n\nIn response to the pandemic, participants reported later sleep timing, especially during workdays. Most participants (46%) exhibited a reduction in their SJL, whereas 20% increased it; and 34% reported no change in SJL. Notably, we found that both increased and decreased SJL, as a result of the COVID-19 pandemic, were associated with later sleep midpoint (indicating a later chronotype) as well as more recurrent and moderate-to-severe symptoms of insomnia (about 23-54% higher odds ratio than subjects with unchanged SJL). Primarily those with reduced SJL shifted their bedtimes to a later timepoint, compared with those without changes in SJL.\n\nOur findings offer important insights into how self-reported changes to the stability of sleep/wake timing, as reflected by changes in SJL, can be a critical marker of the risk of experiencing insomnia-related symptoms - even when individuals manage to reduce their social jetlag. These findings emphasize the clinical importance of analyzing sleep-wake regularity.", "doi": "10.2147/NSS.S327365", "pmid": "34675720", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "327365"}, {"db": "pmc", "key": "PMC8502537"}], "notes": [], "created": "2021-10-26T18:11:31.595Z", "modified": "2021-10-26T18:11:32.221Z"}, {"entity": "publication", "iuid": "a124c47fcd2d40ed9743d00c5abf6747", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a124c47fcd2d40ed9743d00c5abf6747.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a124c47fcd2d40ed9743d00c5abf6747"}}, "title": "Self-Transcendence as a Buffer Against COVID-19 Suffering: The Development and Validation of the Self-Transcendence Measure-B.", "authors": [{"family": "Wong", "given": "Paul T P", "initials": "PTP"}, {"family": "Arslan", "given": "G\u00f6kmen", "initials": "G"}, {"family": "Bowers", "given": "Victoria L", "initials": "VL"}, {"family": "Peacock", "given": "Edward J", "initials": "EJ"}, {"family": "Kjell", "given": "Oscar Nils Erik", "initials": "ONE"}, {"family": "Ivtzan", "given": "Itai", "initials": "I"}, {"family": "Lomas", "given": "Tim", "initials": "T"}], "type": "journal article", "published": "2021-10-06", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "12", "issue": null, "pages": "648549"}, "abstract": "The age of COVID-19 calls for a different approach toward global well-being and flourishing through the transcendence suffering as advocated by existential positive psychology. In the present study, we primarily explained what self-transcendence is and why it represents the most promising path for human beings to flourish through the transformation of suffering in a difficult and uncertain world. After reviewing the literature on self-transcendence experiences, we concluded that the model of self-transcendence presented by Frankl is able to integrate both of the characteristics associated with self-transcendence. Afterward, we discussed how the self-transcendence paradigm proposed by Wong, an extension of the model by Frankl, may help awaken our innate capacity for connections with the true self, with others, and with God or something larger than oneself. We presented self-transcendence as a less-traveled but more promising route to achieve personal growth and mental health in troubled times. Finally, we presented the history of the development and psychometrics of the Self-Transcendence Measure-Brief (STM-B) and reported the empirical evidence that self-transcendence served as a buffer against COVID-19 suffering. The presented data in the current study suggested that the best way to overcome pandemic suffering and mental health crises is to cultivate self-transcendence.", "doi": "10.3389/fpsyg.2021.648549", "pmid": "34690853", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8527188"}], "notes": [], "created": "2021-10-26T18:20:37.527Z", "modified": "2022-02-17T10:26:17.592Z"}, {"entity": "publication", "iuid": "320201f5551b4ad4b0fe9d47ac3d3376", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/320201f5551b4ad4b0fe9d47ac3d3376.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/320201f5551b4ad4b0fe9d47ac3d3376"}}, "title": "Experiences of Renal Replacement Therapy Delivery in Swedish Intensive Care Units during the COVID-19 Pandemic.", "authors": [{"family": "Hertzberg", "given": "Daniel", "initials": "D"}, {"family": "Renberg", "given": "M\u00e5rten", "initials": "M"}, {"family": "Nyman", "given": "Jesper", "initials": "J"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "Rimes Stigare", "given": "Claire", "initials": "C"}], "type": "journal article", "published": "2021-10-06", "journal": {"title": "Blood Purif", "issn": "1421-9735", "pages": "1-6", "issn-l": null}, "abstract": "The COVID-19 pandemic led to a rapidly increased demand for intensive care unit (ICU) and renal replacement therapy (RRT) worldwide. RRT delivery was threatened by a lack of specially trained staff and equipment. We investigated how the first wave of COVID-19 affected RRT delivery in Swedish ICUs.\n\nAn Internet-based questionnaire was sent to ICU lead physicians which included quantitative and qualitative questions regarding RRT demand, equipment availability, and use of continuous renal replacement therapy (CRRT), intermittent haemodialysis (IHD), and peritoneal dialysis (PD) during spring 2020.\n\nTwenty-five ICUs responded and these treated 64% of COVID-19 ICU patients in Sweden. ICU capacity increased by 292% (IQR 171-347%). Median peak capacity was reached during the 18th week of the year. RRT use increased overall by 133% and in Stockholm by 188%. 36% of units sequestered CRRT machines. IHD was used in 68% and PD in 12% of ICUs. RRT fluid and filter shortages were experienced by 45% and 33% of wards, respectively; consequently, prescription alterations were made by 24% of ICUs. Calcium solution shortages were reported in 12% of units that led to citrate protocol changes. Staffing shortages resulted in RRT sometimes being delivered by non-RRT-trained staff, safety incidents relating to this occurred, although no patient harm was reported.\n\nDuring the first wave of the COVID-19 pandemic, RRT demand increased extensively causing staff and equipment shortages, altered CRRT protocols, and increased use of IHD and PD. The impact on patient outcomes should be assessed to effectively plan for further surge capacity RRT demand.", "doi": "10.1159/000519261", "pmid": "34614497", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "000519261"}], "notes": [], "created": "2021-10-10T15:25:47.568Z", "modified": "2021-10-10T15:25:47.591Z"}, {"entity": "publication", "iuid": "2325938297904701a52685931800a279", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2325938297904701a52685931800a279.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2325938297904701a52685931800a279"}}, "title": "Distance learning in higher education during COVID-19: The role of basic psychological needs and intrinsic motivation for persistence and procrastination-a multi-country study.", "authors": [{"family": "Pelikan", "given": "Elisabeth R", "initials": "ER", "orcid": "0000-0003-2317-9237", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7015e04c057e420ab0b089a179feaed0.json"}}, {"family": "Korlat", "given": "Selma", "initials": "S", "orcid": "0000-0001-5719-5222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb333a31bbcf430c8bc4e88aad915429.json"}}, {"family": "Reiter", "given": "Julia", "initials": "J", "orcid": "0000-0002-7451-9441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d718a2b09a844ecac9d63f048732d91.json"}}, {"family": "Holzer", "given": "Julia", "initials": "J", "orcid": "0000-0002-0029-3291", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb443253e26f454589e051a5ab7cc115.json"}}, {"family": "Mayerhofer", "given": "Martin", "initials": "M", "orcid": "0000-0002-2978-4385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0477f9f8f9904dc6b257c5f6d31386fb.json"}}, {"family": "Schober", "given": "Barbara", "initials": "B"}, {"family": "Spiel", "given": "Christiane", "initials": "C"}, {"family": "Hamzallari", "given": "Oriola", "initials": "O", "orcid": "0000-0002-1154-7779", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7cfac7d82c94ba8833a7aa3fea2c1f0.json"}}, {"family": "Uka", "given": "Ana", "initials": "A", "orcid": "0000-0002-9039-8504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/813556c4adc8489cab0cfd710d42b0b3.json"}}, {"family": "Chen", "given": "Jiarui", "initials": "J"}, {"family": "V\u00e4lim\u00e4ki", "given": "Maritta", "initials": "M"}, {"family": "Puhari\u0107", "given": "Zrinka", "initials": "Z"}, {"family": "Anusionwu", "given": "Kelechi Evans", "initials": "KE", "orcid": "0000-0002-2946-076X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c0f0fc7278c448fb35962ececa3a0ed.json"}}, {"family": "Okocha", "given": "Angela Nkem", "initials": "AN", "orcid": "0000-0002-8668-6183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4fc8fcd5e4754cfeb7f671155089bc97.json"}}, {"family": "Zabrodskaja", "given": "Anastassia", "initials": "A"}, {"family": "Salmela-Aro", "given": "Katariina", "initials": "K"}, {"family": "K\u00e4ser", "given": "Udo", "initials": "U"}, {"family": "Schultze-Krumbholz", "given": "Anja", "initials": "A"}, {"family": "Wachs", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-2787-6646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b86f9438ea894681afe3ed3b75b93c91.json"}}, {"family": "Fri\u00f0riksson", "given": "Finnur", "initials": "F"}, {"family": "Gunn\u00fe\u00f3rsd\u00f3ttir", "given": "Herm\u00edna", "initials": "H"}, {"family": "H\u00f6ller", "given": "Yvonne", "initials": "Y"}, {"family": "Aoyama", "given": "Ikuko", "initials": "I"}, {"family": "Ieshima", "given": "Akihiko", "initials": "A", "orcid": "0000-0001-6423-375X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5df4f3f0e605406fbe93edba3abfaa49.json"}}, {"family": "Toda", "given": "Yuichi", "initials": "Y"}, {"family": "Konjufca", "given": "Jon", "initials": "J"}, {"family": "Llullaku", "given": "Njomza", "initials": "N"}, {"family": "Gedutien\u0117", "given": "Reda", "initials": "R"}, {"family": "Borg Axisa", "given": "Glorianne", "initials": "G"}, {"family": "Avirovic Bundalevska", "given": "Irena", "initials": "I", "orcid": "0000-0002-1609-000X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7b03d30dc8a437789778827cbdc9bc2.json"}}, {"family": "Keskinova", "given": "Angelka", "initials": "A", "orcid": "0000-0002-3698-0501", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a67f06d40fd042bd8d7ecbfdff33933f.json"}}, {"family": "Radulovic", "given": "Makedonka", "initials": "M", "orcid": "0000-0002-3753-1521", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9da2b609843042ada1ed1f22296e1d08.json"}}, {"family": "Lewandowska-Walter", "given": "Aleksandra", "initials": "A"}, {"family": "Micha\u0142ek-Kwiecie\u0144", "given": "Justyna", "initials": "J"}, {"family": "Plichta", "given": "Piotr", "initials": "P"}, {"family": "Py\u017calski", "given": "Jacek", "initials": "J", "orcid": "0000-0001-5817-276X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8072f973e24740f88e300907e166d361.json"}}, {"family": "Walter", "given": "Natalia", "initials": "N", "orcid": "0000-0002-2347-9312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a00af7a0664848bbbf2d9356924d8aca.json"}}, {"family": "Cautisanu", "given": "Cristina", "initials": "C", "orcid": "0000-0002-4457-1185", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/308dce29591748d087647da56445b1ca.json"}}, {"family": "Voda", "given": "Ana Iolanda", "initials": "AI"}, {"family": "Gao", "given": "Shang", "initials": "S", "orcid": "0000-0002-3722-6797", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/045bf868b2e14614985d01eab4a1a021.json"}}, {"family": "Islam", "given": "Sirajul", "initials": "S", "orcid": "0000-0002-7907-6037", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e05dfe6ec254efe8e7f98a35ab5728d.json"}}, {"family": "Wistrand", "given": "Kai", "initials": "K", "orcid": "0000-0002-1394-3783", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e776d6c1c4b4cdaa5452120b388678c.json"}}, {"family": "Wright", "given": "Michelle F", "initials": "MF"}, {"family": "L\u00fcftenegger", "given": "Marko", "initials": "M", "orcid": "0000-0001-8112-976X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f123b600b20342719f0c25cce9974e60.json"}}], "type": "journal article", "published": "2021-10-06", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0257346", "issn-l": "1932-6203"}, "abstract": "Due to the COVID-19 pandemic, higher educational institutions worldwide switched to emergency distance learning in early 2020. The less structured environment of distance learning forced students to regulate their learning and motivation more independently. According to self-determination theory (SDT), satisfaction of the three basic psychological needs for autonomy, competence and social relatedness affects intrinsic motivation, which in turn relates to more active or passive learning behavior. As the social context plays a major role for basic need satisfaction, distance learning may impair basic need satisfaction and thus intrinsic motivation and learning behavior. The aim of this study was to investigate the relationship between basic need satisfaction and procrastination and persistence in the context of emergency distance learning during the COVID-19 pandemic in a cross-sectional study. We also investigated the mediating role of intrinsic motivation in this relationship. Furthermore, to test the universal importance of SDT for intrinsic motivation and learning behavior under these circumstances in different countries, we collected data in Europe, Asia and North America. A total of N = 15,462 participants from Albania, Austria, China, Croatia, Estonia, Finland, Germany, Iceland, Japan, Kosovo, Lithuania, Poland, Malta, North Macedonia, Romania, Sweden, and the US answered questions regarding perceived competence, autonomy, social relatedness, intrinsic motivation, procrastination, persistence, and sociodemographic background. Our results support SDT's claim of universality regarding the relation between basic psychological need fulfilment, intrinsic motivation, procrastination, and persistence. However, whereas perceived competence had the highest direct effect on procrastination and persistence, social relatedness was mainly influential via intrinsic motivation.", "doi": "10.1371/journal.pone.0257346", "pmid": "34613978", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-10408"}, {"db": "pmc", "key": "PMC8494346"}], "notes": [], "created": "2021-10-10T15:26:30.528Z", "modified": "2021-10-10T15:26:40.706Z"}, {"entity": "publication", "iuid": "68ef25c5e76d44af802d7349a8e8157c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68ef25c5e76d44af802d7349a8e8157c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68ef25c5e76d44af802d7349a8e8157c"}}, "title": "COVID-19 vaccination in patients with heart failure: a position paper of the Heart Failure Association of the European Society of Cardiology.", "authors": [{"family": "Rosano", "given": "Giuseppe", "initials": "G"}, {"family": "Jankowska", "given": "Ewa A", "initials": "EA"}, {"family": "Ray", "given": "Robin", "initials": "R"}, {"family": "Metra", "given": "Marco", "initials": "M"}, {"family": "Abdelhamid", "given": "Magdy", "initials": "M"}, {"family": "Adamopoulos", "given": "Stamatis", "initials": "S"}, {"family": "Anker", "given": "Stefan D", "initials": "SD"}, {"family": "Bayes-Genis", "given": "Antoni", "initials": "A"}, {"family": "Belenkov", "given": "Yuri", "initials": "Y"}, {"family": "Gal", "given": "Tuvia B", "initials": "TB"}, {"family": "B\u00f6hm", "given": "Michael", "initials": "M"}, {"family": "Chioncel", "given": "Ovidiu", "initials": "O"}, {"family": "Cohen-Solal", "given": "Alain", "initials": "A"}, {"family": "Farmakis", "given": "Dimitrios", "initials": "D"}, {"family": "Filippatos", "given": "Gerasimos", "initials": "G"}, {"family": "Gonz\u00e1lez", "given": "Arantxa", "initials": "A"}, {"family": "Gustafsson", "given": "Finn", "initials": "F"}, {"family": "Hill", "given": "Loreena", "initials": "L"}, {"family": "Jaarsma", "given": "Tiny", "initials": "T"}, {"family": "Jouhra", "given": "Fadi", "initials": "F"}, {"family": "Lainscak", "given": "Mitja", "initials": "M"}, {"family": "Lambrinou", "given": "Ekaterini", "initials": "E"}, {"family": "Lopatin", "given": "Yury", "initials": "Y"}, {"family": "Lund", "given": "Lars H", "initials": "LH"}, {"family": "Milicic", "given": "Davor", "initials": "D"}, {"family": "Moura", "given": "Brenda", "initials": "B"}, {"family": "Mullens", "given": "Wilfried", "initials": "W"}, {"family": "Piepoli", "given": "Massimo F", "initials": "MF"}, {"family": "Ponikowski", "given": "Piotr", "initials": "P"}, {"family": "Rakisheva", "given": "Amina", "initials": "A"}, {"family": "Ristic", "given": "Arsen", "initials": "A"}, {"family": "Savarese", "given": "Gianluigi", "initials": "G"}, {"family": "Seferovic", "given": "Petar", "initials": "P"}, {"family": "Senni", "given": "Michele", "initials": "M"}, {"family": "Thum", "given": "Thomas", "initials": "T"}, {"family": "Tocchetti", "given": "Carlo G", "initials": "CG"}, {"family": "Van Linthout", "given": "Sophie", "initials": "S"}, {"family": "Volterrani", "given": "Maurizio", "initials": "M"}, {"family": "Coats", "given": "Andrew J S", "initials": "AJS"}], "type": "journal article", "published": "2021-10-06", "journal": {"title": "Eur J Heart Fail", "issn": "1879-0844", "issn-l": "1388-9842"}, "abstract": "Patients with heart failure (HF) who contract SARS-CoV-2 infection are at a higher risk of cardiovascular and non-cardiovascular morbidity and mortality. Regardless of therapeutic attempts in COVID-19, vaccination remains the most promising global approach at present for controlling this disease. There are several concerns and misconceptions regarding the clinical indications, optimal mode of delivery, safety and efficacy of COVID-19 vaccines for patients with HF. This document provides guidance to all healthcare professionals regarding the implementation of a COVID-19 vaccination scheme in patients with HF. COVID-19 vaccination is indicated in all patients with HF, including those who are immunocompromised (e.g. after heart transplantation receiving immunosuppressive therapy) and with frailty syndrome. It is preferable to vaccinate against COVID-19 patients with HF in an optimal clinical state, which would include clinical stability, adequate hydration and nutrition, optimized treatment of HF and other comorbidities (including iron deficiency), but corrective measures should not be allowed to delay vaccination. Patients with HF who have been vaccinated against COVID-19 need to continue precautionary measures, including the use of facemasks, hand hygiene and social distancing. Knowledge on strategies preventing SARS-CoV-2 infection (including the COVID-19 vaccination) should be included in the comprehensive educational programmes delivered to patients with HF. This article is protected by copyright. All rights reserved.", "doi": "10.1002/ejhf.2356", "pmid": "34612556", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:28:10.061Z", "modified": "2021-10-10T15:28:10.071Z"}, {"entity": "publication", "iuid": "56c9f4f3d9104458b6a4725592079790", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56c9f4f3d9104458b6a4725592079790.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56c9f4f3d9104458b6a4725592079790"}}, "title": "Metabolic Perturbation Associated With COVID-19 Disease Severity and SARS-CoV-2 Replication.", "authors": [{"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Nordqvist", "given": "Hampus", "initials": "H"}, {"family": "Ambikan", "given": "Anoop T", "initials": "AT", "orcid": "0000-0002-5221-9085", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b14201e4cc547bd8b47d8c27bd0189d.json"}}, {"family": "Gupta", "given": "Soham", "initials": "S", "orcid": "0000-0003-1136-3010", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e94ad93c8263474ab2a9f46a82e763ad.json"}}, {"family": "Sperk", "given": "Maike", "initials": "M"}, {"family": "Svensson-Akusj\u00e4rvi", "given": "Sara", "initials": "S", "orcid": "0000-0002-1086-5409", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20ca29a0c3544bacbf5c44e60263f0a3.json"}}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "Benfeitas", "given": "Rui", "initials": "R", "orcid": "0000-0001-7972-0083", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88e286a997e8409193c9c8713d324f81.json"}}, {"family": "Saccon", "given": "Elisa", "initials": "E", "orcid": "0000-0003-3283-4432", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28cbb3510cbc4bf5b4db2bee1689467f.json"}}, {"family": "Ponnan", "given": "Sivasankaran Munusamy", "initials": "SM"}, {"family": "Rodriguez", "given": "Jimmy Esneider", "initials": "JE", "orcid": "0000-0002-6735-3332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/687f0a9fa4a94f1cb2d7c7bcf504a48d.json"}}, {"family": "Nikouyan", "given": "Negin", "initials": "N"}, {"family": "Odeh", "given": "Amani", "initials": "A"}, {"family": "Ahl\u00e9n", "given": "Gustaf", "initials": "G"}, {"family": "Asghar", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-9017-2206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0e95806bb4a4dca8363a6d9618c678d.json"}}, {"family": "S\u00e4llberg", "given": "Matti", "initials": "M"}, {"family": "Vesterbacka", "given": "Jan", "initials": "J"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "V\u00e9gv\u00e1ri", "given": "\u00c1kos", "initials": "\u00c1", "orcid": "0000-0002-1287-0906", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d68085d6c3b541afbca67e17b2c42cd7.json"}}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Treutiger", "given": "Carl Johan", "initials": "CJ"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "journal article", "published": "2021-10-05", "journal": {"title": "Mol Cell Proteomics", "issn": "1535-9484", "issn-l": null, "volume": "20", "issue": null, "pages": "100159"}, "abstract": "Viruses hijack host metabolic pathways for their replicative advantage. In this study, using patient-derived multiomics data and in vitro infection assays, we aimed to understand the role of key metabolic pathways that can regulate severe acute respiratory syndrome coronavirus-2 reproduction and their association with disease severity. We used multiomics platforms (targeted and untargeted proteomics and untargeted metabolomics) on patient samples and cell-line models along with immune phenotyping of metabolite transporters in patient blood cells to understand viral-induced metabolic modulations. We also modulated key metabolic pathways that were identified using multiomics data to regulate the viral reproduction in vitro. Coronavirus disease 2019 disease severity was characterized by increased plasma glucose and mannose levels. Immune phenotyping identified altered expression patterns of carbohydrate transporter, glucose transporter 1, in CD8+ T cells, intermediate and nonclassical monocytes, and amino acid transporter, xCT, in classical, intermediate, and nonclassical monocytes. In in vitro lung epithelial cell (Calu-3) infection model, we found that glycolysis and glutaminolysis are essential for virus replication, and blocking these metabolic pathways caused significant reduction in virus production. Taken together, we therefore hypothesized that severe acute respiratory syndrome coronavirus-2 utilizes and rewires pathways governing central carbon metabolism leading to the efflux of toxic metabolites and associated with disease severity. Thus, the host metabolic perturbation could be an attractive strategy to limit the viral replication and disease severity.", "doi": "10.1016/j.mcpro.2021.100159", "pmid": "34619366", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S1535-9476(21)00131-6"}, {"db": "pmc", "key": "PMC8490130"}], "notes": [], "created": "2021-03-08T14:54:26.783Z", "modified": "2022-02-16T07:35:24.059Z"}, {"entity": "publication", "iuid": "3af6dbea939b4957afb69291a136ea31", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3af6dbea939b4957afb69291a136ea31.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3af6dbea939b4957afb69291a136ea31"}}, "title": "High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19.", "authors": [{"family": "Lourda", "given": "Magda", "initials": "M", "orcid": "0000-0003-3155-1123", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09048dd72d384232932b004149b543e4.json"}}, {"family": "Dzidic", "given": "Majda", "initials": "M"}, {"family": "Hertwig", "given": "Laura", "initials": "L", "orcid": "0000-0002-1170-0948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbc76f6fbe8b4fcebfa928374618b304.json"}}, {"family": "Bergsten", "given": "Helena", "initials": "H"}, {"family": "Palma Medina", "given": "Laura M", "initials": "LM"}, {"family": "Sinha", "given": "Indranil", "initials": "I", "orcid": "0000-0002-2513-5927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/261f9a5460a64c1fb21331b6619b068d.json"}}, {"family": "Kvedaraite", "given": "Egle", "initials": "E"}, {"family": "Chen", "given": "Puran", "initials": "P", "orcid": "0000-0002-2890-0022", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d90f1cd607240b6bad38c32855b58d2.json"}}, {"family": "Muvva", "given": "Jagadeeswara R", "initials": "JR"}, {"family": "Gorin", "given": "Jean-Baptiste", "initials": "JB"}, {"family": "Cornillet", "given": "Martin", "initials": "M", "orcid": "0000-0001-7981-0927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20d0c2fd2be843668806a91d2d83104b.json"}}, {"family": "Emg\u00e5rd", "given": "Johanna", "initials": "J"}, {"family": "Moll", "given": "Kirsten", "initials": "K"}, {"family": "Garc\u00eda", "given": "Marina", "initials": "M", "orcid": "0000-0002-9130-3933", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5b109d7a54e4c05a48e0f21c4432be6.json"}}, {"family": "Maleki", "given": "Kimia T", "initials": "KT", "orcid": "0000-0001-5382-5477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c0313be527f49c0b41a37115a68408d.json"}}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Flodstr\u00f6m-Tullberg", "given": "Malin", "initials": "M"}, {"family": "Brighenti", "given": "Susanna", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J"}, {"family": "Malmberg", "given": "Karl-Johan", "initials": "KJ"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK", "orcid": "0000-0002-6275-0750", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61225c074353413bb0b19c43b555732a.json"}}, {"family": "Henter", "given": "Jan-Inge", "initials": "JI", "orcid": "0000-0002-0629-2126", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a88b3feb9554be1804f4836f2dc36de.json"}}, {"family": "Folkesson", "given": "Elin", "initials": "E"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S", "orcid": "0000-0002-2446-4323", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/363ff940d9c64575a11bd45372927b2c.json"}}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Aleman", "given": "Soo", "initials": "S", "orcid": "0000-0003-0461-4870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b0edb2db8d840989936f67047ce91de.json"}}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-8801-3169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37509c3832244b019b91a1fe2cbe183e.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG", "orcid": "0000-0003-0908-7387", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48a59f01e46c41038301a586178e8e2a.json"}}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4691d38f3268433696d7c65ea235a12b.json"}}, {"family": "Svensson", "given": "Mattias", "initials": "M", "orcid": "0000-0003-1695-7934", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7ae76a597164d02b4fcfadfe53c48a3.json"}}, {"family": "Ponzetta", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3224-802X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8d6bca49dc24e558ca8f0b3637d7702.json"}}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A", "orcid": "0000-0001-9372-1795", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb1e61066d6451c920200f83e99cb9e.json"}}, {"family": "Chambers", "given": "Benedict J", "initials": "BJ", "orcid": "0000-0003-0437-8441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6089d99ec42d475f8f57c8d8cc1ff1de.json"}}, {"family": "Karolinska KI/K COVID-19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-10-05", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "issn-l": "0027-8424", "volume": "118", "issue": "40", "pages": null}, "abstract": "Since the outset of the COVID-19 pandemic, increasing evidence suggests that the innate immune responses play an important role in the disease development. A dysregulated inflammatory state has been proposed as a key driver of clinical complications in COVID-19, with a potential detrimental role of granulocytes. However, a comprehensive phenotypic description of circulating granulocytes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients is lacking. In this study, we used high-dimensional flow cytometry for granulocyte immunophenotyping in peripheral blood collected from COVID-19 patients during acute and convalescent phases. Severe COVID-19 was associated with increased levels of both mature and immature neutrophils, and decreased counts of eosinophils and basophils. Distinct immunotypes were evident in COVID-19 patients, with altered expression of several receptors involved in activation, adhesion, and migration of granulocytes (e.g., CD62L, CD11a/b, CD69, CD63, CXCR4). Paired sampling revealed recovery and phenotypic restoration of the granulocytic signature in the convalescent phase. The identified granulocyte immunotypes correlated with distinct sets of soluble inflammatory markers, supporting pathophysiologic relevance. Furthermore, clinical features, including multiorgan dysfunction and respiratory function, could be predicted using combined laboratory measurements and immunophenotyping. This study provides a comprehensive granulocyte characterization in COVID-19 and reveals specific immunotypes with potential predictive value for key clinical features associated with COVID-19.", "doi": "10.1073/pnas.2109123118", "pmid": "34548411", "labels": {"Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2109123118"}], "notes": [], "created": "2021-02-02T11:37:31.818Z", "modified": "2021-09-23T05:17:12.682Z"}, {"entity": "publication", "iuid": "f4a45618e0384dfab5459663691b324b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f4a45618e0384dfab5459663691b324b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f4a45618e0384dfab5459663691b324b"}}, "title": "Establishing a COVID-19 pandemic severity assessment surveillance system in Ireland.", "authors": [{"family": "Domegan", "given": "Lisa", "initials": "L", "orcid": "0000-0002-7483-6703", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b12d1831028479eb6303b6c8d348ccb.json"}}, {"family": "Garvey", "given": "Patricia", "initials": "P"}, {"family": "McEnery", "given": "Maeve", "initials": "M"}, {"family": "Fiegenbaum", "given": "Rachel", "initials": "R"}, {"family": "Brabazon", "given": "Elaine", "initials": "E"}, {"family": "Quintyne", "given": "Keith Ian", "initials": "KI"}, {"family": "O'Connor", "given": "Lois", "initials": "L"}, {"family": "Cuddihy", "given": "John", "initials": "J"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}], "type": "journal article", "published": "2021-10-05", "journal": {"title": "Influenza Other Respir Viruses", "issn": "1750-2659", "issn-l": null}, "abstract": "We developed a COVID-19 pandemic severity assessment (PSA) monitoring system in Ireland, in order to inform and improve public health preparedness, response and recovery. The system based on the World Health Organization (WHO) Pandemic Influenza Severity Assessment (PISA) project included a panel of surveillance parameters for the following indicators: transmissibility, impact and disease severity. Age-specific thresholds were established for each parameter and data visualised using heat maps. The findings from the first pandemic wave in Ireland have shown that the WHO PISA system can be adapted for COVID-19, providing a standardised tool for early warning and monitoring pandemic severity.", "doi": "10.1111/irv.12890", "pmid": "34609049", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:29:42.777Z", "modified": "2021-10-10T15:29:42.827Z"}, {"entity": "publication", "iuid": "539c23ed279c4d11a59b88fe8519bbc5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/539c23ed279c4d11a59b88fe8519bbc5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/539c23ed279c4d11a59b88fe8519bbc5"}}, "title": "Associations of Disease-Modifying Therapies With COVID-19 Severity in Multiple Sclerosis.", "authors": [{"family": "Simpson-Yap", "given": "Steve", "initials": "S", "orcid": "0000-0001-6521-3056", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/845cbea3a2f64b9f880a43d6cc8cdb09.json"}}, {"family": "De Brouwer", "given": "Edward", "initials": "E"}, {"family": "Kalincik", "given": "Tomas", "initials": "T", "orcid": "0000-0003-3778-1376", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d57266f045d648a8b749b6496f4b2fc5.json"}}, {"family": "Rijke", "given": "Nick", "initials": "N"}, {"family": "Hillert", "given": "Jan A", "initials": "JA"}, {"family": "Walton", "given": "Clare", "initials": "C"}, {"family": "Edan", "given": "Gilles", "initials": "G"}, {"family": "Moreau", "given": "Yves", "initials": "Y"}, {"family": "Spelman", "given": "Tim", "initials": "T"}, {"family": "Geys", "given": "Lotte", "initials": "L"}, {"family": "Parciak", "given": "Tina", "initials": "T", "orcid": "0000-0002-1989-3641", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19f442e54aa847db9aeb8df80b28bc2f.json"}}, {"family": "Gautrais", "given": "Clement", "initials": "C"}, {"family": "Lazovski", "given": "Nikola", "initials": "N"}, {"family": "Pirmani", "given": "Ashkan", "initials": "A", "orcid": "0000-0003-4549-1002", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d72bbbd407ef4f5387e6653e68e127fc.json"}}, {"family": "Ardeshirdavanai", "given": "Amin", "initials": "A", "orcid": "0000-0002-7226-7324", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f886fb5d880b48828dd8f72c57deb510.json"}}, {"family": "Forsberg", "given": "Lars", "initials": "L", "orcid": "0000-0002-3536-1813", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b57c570dfe5e489c98831771524f0267.json"}}, {"family": "Glaser", "given": "Anna", "initials": "A"}, {"family": "McBurney", "given": "Robert", "initials": "R", "orcid": "0000-0003-1747-1004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2f7c9449433431198c390f39cf1d930.json"}}, {"family": "Schmidt", "given": "Hollie", "initials": "H"}, {"family": "Bergmann", "given": "Arnfin B", "initials": "AB"}, {"family": "Braune", "given": "Stefan", "initials": "S"}, {"family": "Stahmann", "given": "Alexander", "initials": "A", "orcid": "0000-0001-5308-105X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/da733ad3878f45738e211c7317b3edda.json"}}, {"family": "Middleton", "given": "Rodden", "initials": "R", "orcid": "0000-0002-2130-4420", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7adf9663f3ea4db7b2bfc70b724ad309.json"}}, {"family": "Salter", "given": "Amber", "initials": "A", "orcid": "0000-0002-1088-110X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e108ab0c847c4d5b8e66af7cfb6619ec.json"}}, {"family": "Fox", "given": "Robert J", "initials": "RJ", "orcid": "0000-0002-4263-3717", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c20b76857014771847ad29d94572445.json"}}, {"family": "van der Walt", "given": "Anneke", "initials": "A", "orcid": "0000-0002-4278-7003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4636e8ba06d94593929e1c30619cc500.json"}}, {"family": "Butzkueven", "given": "Helmut", "initials": "H"}, {"family": "Alroughani", "given": "Raed", "initials": "R"}, {"family": "Ozakbas", "given": "Serkan", "initials": "S"}, {"family": "Rojas", "given": "Juan I", "initials": "JI"}, {"family": "van der Mei", "given": "Ingrid", "initials": "I"}, {"family": "Nag", "given": "Nupur", "initials": "N", "orcid": "0000-0002-0271-0781", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e143288e60634d7aae97a2db6c73350a.json"}}, {"family": "Ivanov", "given": "Rumen", "initials": "R"}, {"family": "Sciascia do Olival", "given": "Guilherme", "initials": "G", "orcid": "0000-0002-2717-7522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67a109d6755d46528b376eab394b3f44.json"}}, {"family": "Dias", "given": "Alice Estavo", "initials": "AE"}, {"family": "Magyari", "given": "Melinda", "initials": "M", "orcid": "0000-0002-0972-5222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4138641b9754548a434173a3f677e4a.json"}}, {"family": "Brum", "given": "Doralina", "initials": "D"}, {"family": "Mendes", "given": "Maria Fernanda", "initials": "MF"}, {"family": "Alonso", "given": "Ricardo N", "initials": "RN"}, {"family": "Nicholas", "given": "Richard S", "initials": "RS"}, {"family": "Bauer", "given": "Johana", "initials": "J"}, {"family": "Chertcoff", "given": "An\u00edbal Sebasti\u00e1n", "initials": "AS"}, {"family": "Zabalza", "given": "Anna", "initials": "A", "orcid": "0000-0003-3860-5251", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f24a8041d09442178e1f1f007f20c3e5.json"}}, {"family": "Arrambide", "given": "Georgina", "initials": "G", "orcid": "0000-0002-2657-5510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45c169a840fe487e8ed7b286e6c3708f.json"}}, {"family": "Fidao", "given": "Alex", "initials": "A"}, {"family": "Comi", "given": "Giancarlo", "initials": "G"}, {"family": "Peeters", "given": "Liesbet", "initials": "L"}], "type": "journal article", "published": "2021-10-05", "journal": {"title": "Neurology", "issn": "1526-632X", "issn-l": "0028-3878"}, "abstract": "People with multiple sclerosis (MS) are a vulnerable group for severe COVID- 19, particularly those taking immunosuppressive disease-modifying therapies (DMTs). We examined the characteristics of COVID-19 severity in an international sample of people with MS.\n\nData from 12 data-sources in 28 countries were aggregated (sources could include patients from 1-12 countries). Demographic (age, sex), clinical (MS-phenotype, disability), and DMT (untreated, alemtuzumab, cladribine, dimethyl-fumarate, glatiramer acetate, interferon, natalizumab, ocrelizumab, rituximab, siponimod, other DMTs) covariates were queried, alongside COVID-19 severity outcomes, hospitalisation, ICU admission, requiring artificial ventilation, and death. Characteristics of outcomes were assessed in patients with suspected/confirmed COVID-19 using multilevel mixed-effects logistic regression, adjusted for age, sex, MS-phenotype, and EDSS.\n\n657(28.1%) with suspected and 1,683(61.9%) with confirmed COVID-19 were analysed. Among suspected+confirmed and confirmed-only COVID-19, 20.9% and 26.9% were hospitalised, 5.4% and 7.2% were admitted to ICU, 4.1% and 5.4% required artificial ventilation, and 3.2% and 3.9% died. Older age, progressive MS-phenotype, and higher disability were associated with worse COVID-19 outcomes. Compared to dimethyl-fumarate, ocrelizumab and rituximab were associated with hospitalisation (aOR=1.56,95%CI=1.01- 2.41; aOR=2.43,95%CI=1.48-4.02) and ICU admission (aOR=2.30,95%CI=0.98-5.39;aOR=3.93,95%CI=1.56-9.89), though only rituximab was associated with higher risk of artificial ventilation (aOR=4.00,95%CI=1.54-10.39). Compared to pooled other DMTs, ocrelizumab and rituximab were associated with hospitalisation (aOR=1.75,95%CI=1.29- 2.38; aOR=2.76,95%CI=1.87-4.07) and ICU admission (aOR=2.55,95%CI=1.49-4.36;aOR=4.32,95%CI=2.27-8.23) but only rituximab with artificial ventilation (aOR=6.15,95%CI=3.09-12.27). Compared to natalizumab, ocrelizumab and rituximab wereassociated with hospitalisation (aOR=1.86,95%CI=1.13-3.07; aOR=2.88,95%CI=1.68-4.92) and ICU admission (aOR=2.13,95%CI=0.85-5.35; aOR=3.23,95%CI=1.17-8.91), but only rituximab with ventilation (aOR=5.52,95%CI=1.71-17.84). Importantly, associations persisted on restriction to confirmed COVID-19 cases. No associations were observed between DMTs and death. Stratification by age, MS-phenotype, and EDSS found no indications that DMT associations with COVID-19 severity reflected differential DMT allocation by underlying COVID-19 severity.\n\nUsing the largest cohort of people with MS and COVID-19 available, we demonstrated consistent associations of rituximab with increased risk of hospitalisation, ICU admission, and requiring artificial ventilation, and ocrelizumab with hospitalisation and ICU admission. Despite the study's cross-sectional design, the internal and external consistency of these results with prior studies suggests rituximab/ocrelizumab use may be a risk factor for more severe COVID-19.", "doi": "10.1212/WNL.0000000000012753", "pmid": "34610987", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "WNL.0000000000012753"}], "notes": [], "created": "2021-10-10T15:28:34.500Z", "modified": "2021-10-10T15:28:34.892Z"}, {"entity": "publication", "iuid": "0d721ff011d1404d8b5d41856ba512d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d721ff011d1404d8b5d41856ba512d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d721ff011d1404d8b5d41856ba512d4"}}, "title": "Adverse events of special interest for COVID-19 vaccines - background incidences vary by sex, age and time period and are affected by the pandemic", "authors": [{"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW"}, {"family": "Hammar", "given": "Niklas", "initials": "N"}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Kirui", "given": "Brian K", "initials": "BK"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "posted-content", "published": "2021-10-05", "journal": {"title": "MedRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.10.04.21263507", "pmid": null, "labels": {"Category: Health": null, "Research Area: Vaccine": null, "Funder: KAW/SciLifeLab": null, "Type: Preprint": null, "Topics: Register-based research": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-10-21T05:51:25.592Z", "modified": "2022-02-06T17:44:13.656Z"}, {"entity": "publication", "iuid": "ee65ea75cad04e3e90c520ef967bb5f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee65ea75cad04e3e90c520ef967bb5f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee65ea75cad04e3e90c520ef967bb5f8"}}, "title": "Assessing relative COVID-19 mortality during the second wave: a prospective Swiss population-based study.", "authors": [{"family": "Siegfried", "given": "Sandra", "initials": "S", "orcid": "0000-0002-7312-1001", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5e6f621879e43d589a82fae0ae5d7d6.json"}}, {"family": "Bopp", "given": "Matthias", "initials": "M"}, {"family": "G\u00fcnthard", "given": "Huldrych", "initials": "H"}, {"family": "Keiser", "given": "Olivia", "initials": "O"}, {"family": "Weibull", "given": "Caroline E", "initials": "CE"}, {"family": "Crowther", "given": "Michael", "initials": "M"}, {"family": "Hothorn", "given": "Torsten", "initials": "T", "orcid": "0000-0001-8301-0471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a9fe39a0c764477ab308928f6e8228b.json"}}], "type": "journal article", "published": "2021-10-04", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "10", "pages": "e051164", "issn-l": "2044-6055"}, "abstract": "During the first COVID-19 wave in Switzerland, relative mortality was at least eight times higher compared with the uninfected general population. We aimed to assess sex-specific and age-specific relative mortality associated with a SARS-CoV-2 diagnosis during the second wave.\n\nProspective population-based study.\n\nIndividuals testing positive for SARS-CoV-2 after the start of the second wave on 1 October 2020 were followed up until death or administrative censoring on 31 December 2020.\n\n5 179 740 inhabitants of Switzerland in fall 2018 aged 35-95 years (without COVID-19) and 257 288 persons tested positive for SARS-CoV-2 by PCR or antigen testing during the second wave.\n\nThe planned outcome measure was time to death from any cause, measured from the date of a SARS-CoV-2 diagnosis or 1 October in the general population. Information on confirmed SARS-CoV-2 diagnoses and deaths was matched by calendar time with the all-cause mortality of the general Swiss population of 2018. Proportional hazards models were used to estimate sex-specific and age-specific mortality rates and probabilities of death within 60 days.\n\nThe risk of death for individuals tested positive for SARS-CoV-2 in the second wave in Switzerland increased at least sixfold compared with the general population. HRs, reflecting the risk attributable to a SARS-CoV-2 infection, were higher for men (1.40, 95% CI 1.29 to 1.52) and increased for each additional year of age (1.01, 95% CI 1.01 to 1.02). COVID-19 mortality was reduced by at least 20% compared with the first wave in spring 2020.\n\nGeneral mortality patterns, increased for men and older persons, were similar in spring and in fall. Absolute and relative COVID-19 mortality was smaller in fall.\n\nThe protocol for this study was registered on 3 December 2020 at https://osf.io/gbd6r.", "doi": "10.1136/bmjopen-2021-051164", "pmid": "34607868", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-051164"}, {"db": "pmc", "key": "PMC8491006"}], "notes": [], "created": "2021-10-10T15:30:25.734Z", "modified": "2021-10-10T15:32:26.473Z"}, {"entity": "publication", "iuid": "04ce8b77317e40369326ca286363bd5b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/04ce8b77317e40369326ca286363bd5b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/04ce8b77317e40369326ca286363bd5b"}}, "title": "ATG and Post-transplant Cyclophosphamide predisposes to inferior outcome when using cryopreserved stem cell grafts.", "authors": [{"family": "Novitzky-Basso", "given": "Igor", "initials": "I", "orcid": "0000-0003-3748-3117", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6f8f01041fa4649b5f3b11d44bae033.json"}}, {"family": "Remberger", "given": "Mats", "initials": "M", "orcid": "0000-0003-0520-4312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/133deb67baba4c55ac292259d1a4500e.json"}}, {"family": "Chen", "given": "Carol", "initials": "C"}, {"family": "Pasi\u0107", "given": "Ivan", "initials": "I", "orcid": "0000-0001-7595-0113", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6f675a4dd4842c496475438e9ce40f5.json"}}, {"family": "Lam", "given": "Wilson", "initials": "W"}, {"family": "Law", "given": "Arjun", "initials": "A"}, {"family": "Gerbitz", "given": "Armin", "initials": "A"}, {"family": "Viswabandya", "given": "Auro", "initials": "A"}, {"family": "Lipton", "given": "Jeffrey H", "initials": "JH", "orcid": "0000-0001-7391-7168", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6366fdc4b85a4d4e99676639ac8aa491.json"}}, {"family": "Kim", "given": "Dennis D", "initials": "DD"}, {"family": "Kumar", "given": "Rajat", "initials": "R"}, {"family": "Mattsson", "given": "Jonas", "initials": "J"}, {"family": "Michelis", "given": "Fotios V", "initials": "FV", "orcid": "0000-0003-2956-0848", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/85171f94f0cb4bb598fa1d6dba89aa6c.json"}}], "type": "journal article", "published": "2021-10-04", "journal": {"title": "Eur J Haematol", "issn": "1600-0609", "issn-l": null}, "abstract": "During 2020, the concurrent novel COVID-19 pandemic lead to widespread cryopreservation of allogeneic HCT grafts based on NMDP and EBMT recommendations, in order to secure grafts before the start of conditioning chemotherapy. We sought to examine the impact of this change in practice on patient outcomes. We analyzed the outcomes of 483 patients who received HSCT between August 2017 and August 2020, at Princess Margaret Cancer Centre, Canada, in the retrospective study, comparing the outcomes between those who received cryopreserved or fresh peripheral blood stem cell grafts. Overall compared to those who received fresh grafts (n=348), patients who received cryopreserved grafts (n=135) had reduced survival and GRFS, reduced incidence of chronic GvHD, delay in neutrophil engraftment and higher graft failure, with no significant difference in relapse incidence or acute GvHD. However, recipients of cryopreserved matched related donor HSCT showed significantly worse OS, NRM, GRFS compared to fresh grafts. Multivariable analysis of the entire cohort showed significant impact of cryopreservation on OS, relapse, cGvHD, graft failure and GRFS. We conclude that cryopreservation was associated with inferior outcomes post-HSCT, possibly due to the combination of ATG and post-transplant cyclophosphamide impacting differential tolerance to cryopreservation on components of the stem cell graft; further studies are warranted to elucidate mechanisms for this observation.", "doi": "10.1111/ejh.13714", "pmid": "34606661", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:55:56.022Z", "modified": "2021-10-11T17:55:56.247Z"}, {"entity": "publication", "iuid": "fa05a20338ca42da8ff871da200388c4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa05a20338ca42da8ff871da200388c4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa05a20338ca42da8ff871da200388c4"}}, "title": "Pooled testing for SARS-CoV-2, options for efficiency at scale.", "authors": [{"family": "Reilly", "given": "Marie", "initials": "M"}, {"family": "Chohan", "given": "Bhavna", "initials": "B"}], "type": "journal article", "published": "2021-10-01", "journal": {"title": "Bull World Health Organ", "issn": "1564-0604", "volume": "99", "issue": "10", "pages": "708-714", "issn-l": null}, "abstract": "Widescale testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is recognized as a key element of surveillance and outbreak control in the coronavirus disease 2019 (COVID-19) pandemic. The practical challenges, however, have often led to testing only symptomatic individuals and their close contacts. As many countries plan for a cautious relaxation of social restrictions, more effective approaches for widescale testing are increasingly important. Early in the COVID-19 pandemic, laboratories in several countries demonstrated the feasibility of detecting SARS-CoV-2 infection by pooled testing, which combines the specimens from several individuals. Since no further testing is needed for individuals in a negative pool, there is potential for greater efficiency of testing. Despite validations of the accuracy of the results and the efficiency in testing specific groups, the benefits of pooling are less acknowledged as a population surveillance strategy that can detect new disease outbreaks without posing restrictions on entire societies. Pooling specimens from natural clusters, such as school classes, sports teams, workplace colleagues and other social networks, would enable timely and cost-effective widescale testing for SARS-CoV-2. The initial result would be readily translatable into action in terms of quarantine and isolation policies. Clusters of uninfected individuals would be quickly identified and immediate local lockdown of positive clusters would be the appropriate and sufficient action while retesting those individuals. By adapting to the social networks of a population, pooled testing offers a cost-efficient surveillance system that is synchronized with quarantine policies that are rational, risk-based and equitable.", "doi": "10.2471/BLT.20.283093", "pmid": "34621088", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Other": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "BLT.20.283093"}, {"db": "pmc", "key": "PMC8477423"}], "notes": [], "created": "2021-10-10T15:09:06.074Z", "modified": "2021-10-10T15:09:06.098Z"}, {"entity": "publication", "iuid": "c702b47064944448a7ec4b0082312820", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c702b47064944448a7ec4b0082312820.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c702b47064944448a7ec4b0082312820"}}, "title": "Physical Activity and Perceived Health in People With Parkinson Disease During the First Wave of Covid-19 Pandemic: A Cross-sectional Study From Sweden.", "authors": [{"family": "Leavy", "given": "Breiffni", "initials": "B"}, {"family": "Hagstr\u00f6mer", "given": "Maria", "initials": "M"}, {"family": "Conradsson", "given": "David Moulaee", "initials": "DM"}, {"family": "Franz\u00e9n", "given": "Erika", "initials": "E"}], "type": "journal article", "published": "2021-10-01", "journal": {"title": "J Neurol Phys Ther", "issn": "1557-0584", "issn-l": null, "volume": "45", "issue": "4", "pages": "266-272"}, "abstract": "People with Parkinson disease (PD) are known to be at risk of physical inactivity and may therefore be especially vulnerable to negative health outcomes during the COVID-19 pandemic due to social distancing recommendations.\r\n\r\nTo investigate sensor-derived physical activity and perceived health of people with PD during the first wave of the COVID-19 pandemic, as well as the factors associated with these outcomes.\r\n\r\nPhysical activity was measured over 7 days using the Actigraph GT3x accelerometer. Data were collected regarding perceived health status and physical activity habits, as well as rehabilitation attendance during the pandemic. Multiple linear and logistic regression analyses were used to identify factors associated with physical activity and perceived changes in health.\r\n\r\nOf 89 participants, a majority (67%) reported a pandemic-related reduction in exercise habits. Women more commonly reported a reduction in scheduled exercise and cancelled rehabilitation than men. Study participants took on average 5876 \u00b1 3180 steps per day. In the multivariate analysis, female gender, being 70 years of age and older, and greater reported mobility problems were associated with being less physically active. A pandemic-induced deterioration in health was reported by 42% and women were 5 times more likely than men to do so (odds ratio: 5.12, 95% confidence interval, 1.87-15.03; P = 0.002).\r\n\r\nDespite a pandemic-related reduction in reported exercise habits and rehabilitation, the participants in this Swedish sample were relatively physically active. However, women were less active at moderate-vigorous levels and were at greater risk of deterioration in perceived health during this time.Video Abstract available for more insight from the authors (see the Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A359).", "doi": "10.1097/NPT.0000000000000372", "pmid": "34369451", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "01253086-900000000-99717"}, {"db": "ClinicalTrials.gov", "key": "NCT03213873"}], "notes": [], "created": "2021-08-11T14:34:18.812Z", "modified": "2022-02-17T10:23:22.720Z"}, {"entity": "publication", "iuid": "88edfc6421854b69bb11ce43ab061062", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/88edfc6421854b69bb11ce43ab061062.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/88edfc6421854b69bb11ce43ab061062"}}, "title": "Low-quality employment trajectories and risk of common mental disorders, substance use disorders and suicide attempt: a longitudinal study of the Swedish workforce.", "authors": [{"family": "Jonsson", "given": "Johanna", "initials": "J"}, {"family": "Muntaner", "given": "Carles", "initials": "C"}, {"family": "Bodin", "given": "Theo", "initials": "T"}, {"family": "Alderling", "given": "Magnus", "initials": "M"}, {"family": "Rebeka", "given": "Rebeka", "initials": "R"}, {"family": "Burstr\u00f6m", "given": "Bo", "initials": "B"}, {"family": "Davis", "given": "Letitia", "initials": "L"}, {"family": "Gunn", "given": "Virginia", "initials": "V"}, {"family": "Hemmingsson", "given": "Tomas", "initials": "T"}, {"family": "Juli\u00e0", "given": "Mireia", "initials": "M"}, {"family": "Kjellberg", "given": "Katarina", "initials": "K"}, {"family": "Kreshpaj", "given": "Bertina", "initials": "B"}, {"family": "Orellana", "given": "Cecilia", "initials": "C"}, {"family": "Padrosa", "given": "Eva", "initials": "E"}, {"family": "Wegman", "given": "David H", "initials": "DH"}, {"family": "Matilla-Santander", "given": "Nuria", "initials": "N"}], "type": "journal article", "published": "2021-10-01", "journal": {"title": "Scand J Work Environ Health", "issn": "1795-990X", "volume": "47", "issue": "7", "pages": "509-520", "issn-l": null}, "abstract": "High-quality longitudinal evidence exploring the mental health risk associated with low-quality employment trajectories is scarce. We therefore aimed to investigate the risk of being diagnosed with common mental disorders, substance use disorders, or suicide attempt according to low-quality employment trajectories.\n\nA longitudinal register-study based on the working population of Sweden (N=2 743 764). Employment trajectories (2005-2009) characterized by employment quality and pattern (constancy, fluctuation, mobility) were created. Hazard ratios (HR) were estimated using Cox proportional hazards regression models for first incidence (2010-2017) diagnosis of common mental disorders, substance use disorders and suicide attempt as dependent on employment trajectories.\n\nWe identified 21 employment trajectories, 10 of which were low quality (21%). With the exception of constant solo self-employment, there was an increased risk of common mental disorders (HR 1.07-1.62) and substance use disorders (HR 1.05-2.19) for all low-quality trajectories. Constant solo self-employment increased the risk for substance use disorders among women, while it reduced the risk of both disorders for men. Half of the low-quality trajectories were associated with a risk increase of suicide attempt (HR 1.08-1.76).\n\nLow-quality employment trajectories represent risk factors for mental disorders and suicide attempt in Sweden, and there might be differential effects according to sex - especially in terms of self-employment. Policies ensuring and maintaining high-quality employment characteristics over time are imperative. Similar prospective studies are needed, also in other contexts, which cover the effects of the Covid-19 pandemic as well as the mechanisms linking employment trajectories with mental health.", "doi": "10.5271/sjweh.3978", "pmid": "34397098", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "3978"}], "notes": [], "created": "2021-08-17T06:41:56.740Z", "modified": "2021-11-18T13:35:17.405Z"}, {"entity": "publication", "iuid": "4f98608ce2d04e9c870261c3e8afcbb2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4f98608ce2d04e9c870261c3e8afcbb2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4f98608ce2d04e9c870261c3e8afcbb2"}}, "title": "Association Between Tumor Necrosis Factor Inhibitors and the Risk of Hospitalization or Death Among Patients With Immune-Mediated Inflammatory Disease and COVID-19.", "authors": [{"family": "Izadi", "given": "Zara", "initials": "Z"}, {"family": "Brenner", "given": "Erica J", "initials": "EJ"}, {"family": "Mahil", "given": "Satveer K", "initials": "SK"}, {"family": "Dand", "given": "Nick", "initials": "N"}, {"family": "Yiu", "given": "Zenas Z N", "initials": "ZZN"}, {"family": "Yates", "given": "Mark", "initials": "M"}, {"family": "Ungaro", "given": "Ryan C", "initials": "RC"}, {"family": "Zhang", "given": "Xian", "initials": "X"}, {"family": "Agrawal", "given": "Manasi", "initials": "M"}, {"family": "Colombel", "given": "Jean-Frederic", "initials": "JF"}, {"family": "Gianfrancesco", "given": "Milena A", "initials": "MA"}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL"}, {"family": "Strangfeld", "given": "Anja", "initials": "A"}, {"family": "Carmona", "given": "Loreto", "initials": "L"}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S"}, {"family": "Klingberg", "given": "Eva", "initials": "E"}, {"family": "Cuomo", "given": "Giovanna", "initials": "G"}, {"family": "Caprioli", "given": "Marta", "initials": "M"}, {"family": "Cruz-Machado", "given": "Ana Rita", "initials": "AR"}, {"family": "Mazeda Pereira", "given": "Ana Carolina", "initials": "AC"}, {"family": "Hasseli", "given": "Rebecca", "initials": "R"}, {"family": "Pfeil", "given": "Alexander", "initials": "A"}, {"family": "Lorenz", "given": "Hanns-Martin", "initials": "HM"}, {"family": "Hoyer", "given": "Bimba Franziska", "initials": "BF"}, {"family": "Trupin", "given": "Laura", "initials": "L"}, {"family": "Rush", "given": "Stephanie", "initials": "S"}, {"family": "Katz", "given": "Patricia", "initials": "P"}, {"family": "Schmajuk", "given": "Gabriela", "initials": "G"}, {"family": "Jacobsohn", "given": "Lindsay", "initials": "L"}, {"family": "Seet", "given": "Andrea M", "initials": "AM"}, {"family": "Al Emadi", "given": "Samar", "initials": "S"}, {"family": "Wise", "given": "Leanna", "initials": "L"}, {"family": "Gilbert", "given": "Emily L", "initials": "EL"}, {"family": "Duarte-Garc\u00eda", "given": "Al\u00ed", "initials": "A"}, {"family": "Valenzuela-Almada", "given": "Maria O", "initials": "MO"}, {"family": "Isnardi", "given": "Carolina A", "initials": "CA"}, {"family": "Quintana", "given": "Rosana", "initials": "R"}, {"family": "Soriano", "given": "Enrique R", "initials": "ER"}, {"family": "Hsu", "given": "Tiffany Y-T", "initials": "TY"}, {"family": "D'Silva", "given": "Kristin M", "initials": "KM"}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA"}, {"family": "Patel", "given": "Naomi J", "initials": "NJ"}, {"family": "Xavier", "given": "Ricardo Machado", "initials": "RM"}, {"family": "Marques", "given": "Claudia Diniz Lopes", "initials": "CDL"}, {"family": "Kakehasi", "given": "Adriana Maria", "initials": "AM"}, {"family": "Flipo", "given": "Ren\u00e9-Marc", "initials": "RM"}, {"family": "Claudepierre", "given": "Pascal", "initials": "P"}, {"family": "Cantagrel", "given": "Alain", "initials": "A"}, {"family": "Goupille", "given": "Philippe", "initials": "P"}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Costello", "given": "Wendy", "initials": "W"}, {"family": "Grainger", "given": "Rebecca", "initials": "R"}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS"}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Sufka", "given": "Paul", "initials": "P"}, {"family": "Robinson", "given": "Philip C", "initials": "PC"}, {"family": "Machado", "given": "Pedro M", "initials": "PM"}, {"family": "Griffiths", "given": "Christopher E M", "initials": "CEM"}, {"family": "Barker", "given": "Jonathan N", "initials": "JN"}, {"family": "Smith", "given": "Catherine H", "initials": "CH"}, {"family": "Yazdany", "given": "Jinoos", "initials": "J"}, {"family": "Kappelman", "given": "Michael D", "initials": "MD"}, {"family": "Psoriasis Patient Registry for Outcomes, Therapy and Epidemiology of COVID-19 Infection (PsoProtect); the Secure Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease (SECURE-IBD); and the COVID-19 Global Rheumatology Allianc", "given": "", "initials": ""}, {"family": "Psoriasis Patient Registry for Outcomes, Therapy and Epidemiology of COVID-19 Infection (PsoProtect); the Secure Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease (SECURE-IBD); and the COVID-19 Global Rheumatology Alliance (GRA)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-10-01", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "volume": "4", "issue": "10", "pages": "e2129639", "issn-l": null}, "abstract": "Although tumor necrosis factor (TNF) inhibitors are widely prescribed globally because of their ability to ameliorate shared immune pathways across immune-mediated inflammatory diseases (IMIDs), the impact of COVID-19 among individuals with IMIDs who are receiving TNF inhibitors remains insufficiently understood.\n\nTo examine the association between the receipt of TNF inhibitor monotherapy and the risk of COVID-19-associated hospitalization or death compared with other commonly prescribed immunomodulatory treatment regimens among adult patients with IMIDs.\n\nThis cohort study was a pooled analysis of data from 3 international COVID-19 registries comprising individuals with rheumatic diseases, inflammatory bowel disease, and psoriasis from March 12, 2020, to February 1, 2021. Clinicians directly reported COVID-19 outcomes as well as demographic and clinical characteristics of individuals with IMIDs and confirmed or suspected COVID-19 using online data entry portals. Adults (age \u226518 years) with a diagnosis of inflammatory arthritis, inflammatory bowel disease, or psoriasis were included.\n\nTreatment exposure categories included TNF inhibitor monotherapy (reference treatment), TNF inhibitors in combination with methotrexate therapy, TNF inhibitors in combination with azathioprine/6-mercaptopurine therapy, methotrexate monotherapy, azathioprine/6-mercaptopurine monotherapy, and Janus kinase (Jak) inhibitor monotherapy.\n\nThe main outcome was COVID-19-associated hospitalization or death. Registry-level analyses and a pooled analysis of data across the 3 registries were conducted using multilevel multivariable logistic regression models, adjusting for demographic and clinical characteristics and accounting for country, calendar month, and registry-level correlations.\n\nA total of 6077 patients from 74 countries were included in the analyses; of those, 3215 individuals (52.9%) were from Europe, 3563 individuals (58.6%) were female, and the mean (SD) age was 48.8 (16.5) years. The most common IMID diagnoses were rheumatoid arthritis (2146 patients [35.3%]) and Crohn disease (1537 patients [25.3%]). A total of 1297 patients (21.3%) were hospitalized, and 189 patients (3.1%) died. In the pooled analysis, compared with patients who received TNF inhibitor monotherapy, higher odds of hospitalization or death were observed among those who received a TNF inhibitor in combination with azathioprine/6-mercaptopurine therapy (odds ratio [OR], 1.74; 95% CI, 1.17-2.58; P = .006), azathioprine/6-mercaptopurine monotherapy (OR, 1.84; 95% CI, 1.30-2.61; P = .001), methotrexate monotherapy (OR, 2.00; 95% CI, 1.57-2.56; P < .001), and Jak inhibitor monotherapy (OR, 1.82; 95% CI, 1.21-2.73; P = .004) but not among those who received a TNF inhibitor in combination with methotrexate therapy (OR, 1.18; 95% CI, 0.85-1.63; P = .33). Similar findings were obtained in analyses that accounted for potential reporting bias and sensitivity analyses that excluded patients with a COVID-19 diagnosis based on symptoms alone.\n\nIn this cohort study, TNF inhibitor monotherapy was associated with a lower risk of adverse COVID-19 outcomes compared with other commonly prescribed immunomodulatory treatment regimens among individuals with IMIDs.", "doi": "10.1001/jamanetworkopen.2021.29639", "pmid": "34661663", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2785080"}], "notes": [], "created": "2021-10-21T05:00:02.951Z", "modified": "2021-10-21T05:00:02.965Z"}, {"entity": "publication", "iuid": "7fc8b99cd85b4160bbeae8e8055a3a47", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7fc8b99cd85b4160bbeae8e8055a3a47.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7fc8b99cd85b4160bbeae8e8055a3a47"}}, "title": "The use of Faecal Microbiota Transplantation (FMT) in Europe: A Europe-wide survey.", "authors": [{"family": "Baunwall", "given": "Simon Mark Dahl", "initials": "SMD"}, {"family": "Terveer", "given": "Elisabeth M", "initials": "EM"}, {"family": "Dahlerup", "given": "Jens Frederik", "initials": "JF"}, {"family": "Erikstrup", "given": "Christian", "initials": "C"}, {"family": "Arkkila", "given": "Perttu", "initials": "P"}, {"family": "Vehreschild", "given": "Maria Jgt", "initials": "MJ"}, {"family": "Ianiro", "given": "Gianluca", "initials": "G"}, {"family": "Gasbarrini", "given": "Antonio", "initials": "A"}, {"family": "Sokol", "given": "Harry", "initials": "H"}, {"family": "Kump", "given": "Patrizia K", "initials": "PK"}, {"family": "Satokari", "given": "Reetta", "initials": "R"}, {"family": "De Looze", "given": "Danny", "initials": "D"}, {"family": "Vermeire", "given": "S\u00e9verine", "initials": "S"}, {"family": "Nakov", "given": "Radislav", "initials": "R"}, {"family": "Brezina", "given": "Jan", "initials": "J"}, {"family": "Helms", "given": "Morten", "initials": "M"}, {"family": "Kjeldsen", "given": "Jens", "initials": "J"}, {"family": "Rode", "given": "Anne A", "initials": "AA"}, {"family": "Kousgaard", "given": "Sabrina Just", "initials": "SJ"}, {"family": "Alric", "given": "Laurent", "initials": "L"}, {"family": "Trang-Poisson", "given": "Caroline", "initials": "C"}, {"family": "Scanzi", "given": "Julien", "initials": "J"}, {"family": "Link", "given": "Alexander", "initials": "A"}, {"family": "Stallmach", "given": "Andreas", "initials": "A"}, {"family": "Kupcinskas", "given": "Juozas", "initials": "J"}, {"family": "Johnsen", "given": "Peter Holger", "initials": "PH"}, {"family": "Garborg", "given": "Kjetil", "initials": "K"}, {"family": "Rodr\u00edguez", "given": "Eugenia S\u00e1nchez", "initials": "ES"}, {"family": "Serrander", "given": "Lena", "initials": "L"}, {"family": "Brummer", "given": "Robert J", "initials": "RJ"}, {"family": "Galp\u00e9rine", "given": "Katerina Tatiana", "initials": "KT"}, {"family": "Goldenberg", "given": "Simon D", "initials": "SD"}, {"family": "Mullish", "given": "Benjamin H", "initials": "BH"}, {"family": "Williams", "given": "Horace Rt", "initials": "HR"}, {"family": "Iqbal", "given": "Tariq H", "initials": "TH"}, {"family": "Ponsioen", "given": "Cyriel", "initials": "C"}, {"family": "Kuijper", "given": "Ed J", "initials": "EJ"}, {"family": "Cammarota", "given": "Giovanni", "initials": "G"}, {"family": "Keller", "given": "Josbert J", "initials": "JJ"}, {"family": "Hvas", "given": "Christian Lodberg", "initials": "CL"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "9", "pages": "100181", "issn-l": null}, "abstract": "Faecal microbiota transplantation (FMT) is an emerging treatment modality, but its current clinical use and organisation are unknown. We aimed to describe the clinical use, conduct, and potential for FMT in Europe.\n\nWe invited all hospital-based FMT centres within the European Council member states to answer a web-based questionnaire covering their clinical activities, organisation, and regulation of FMT in 2019. Responders were identified from trials registered at clinicaltrials.gov and from the United European Gastroenterology (UEG) working group for stool banking and FMT.\n\nIn 2019, 31 FMT centres from 17 countries reported a total of 1,874 (median 25, quartile 10-64) FMT procedures; 1,077 (57%) with Clostridioides difficile infection (CDI) as indication, 791 (42%) with experimental indications, and 6 (0\u20223%) unaccounted for. Adjusted to population size, 0\u2022257 per 100,000 population received FMT for CDI and 0\u2022189 per 100,000 population for experimental indications. With estimated 12,400 (6,100-28,500) annual cases of multiple, recurrent CDI and indication for FMT in Europe, the current European FMT activity covers approximately 10% of the patients with indication. The participating centres demonstrated high safety standards and adherence to international consensus guidelines. Formal or informal regulation from health authorities was present at 21 (68%) centres.\n\nFMT is a widespread routine treatment for multiple, recurrent CDI and an experimental treatment. Embedded within hospital settings, FMT centres operate with high standards across Europe to provide safe FMT. A significant gap in FMT coverage suggests the need to raise clinical awareness and increase the FMT activity in Europe by at least 10-fold to meet the true, indicated need.\n\nNordForsk under the Nordic Council and Innovation Fund Denmark (j.no. 8056-00006B).", "doi": "10.1016/j.lanepe.2021.100181", "pmid": "34693388", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00158-7"}, {"db": "pmc", "key": "PMC8513118"}], "notes": [], "created": "2021-10-26T18:27:35.950Z", "modified": "2021-10-26T18:27:57.245Z"}, {"entity": "publication", "iuid": "5d42e9f095cf48b98731eed07b48a1a8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d42e9f095cf48b98731eed07b48a1a8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d42e9f095cf48b98731eed07b48a1a8"}}, "title": "Spotlight influenza: The 2019/20 influenza season and the impact of COVID-19 on influenza surveillance in the WHO European Region.", "authors": [{"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Sneiderman", "given": "Miriam", "initials": "M"}, {"family": "Martinuka", "given": "Oksana", "initials": "O"}, {"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Fielding", "given": "James", "initials": "J"}, {"family": "Olsen", "given": "Sonja J", "initials": "SJ"}, {"family": "Penttinen", "given": "Pasi", "initials": "P"}, {"family": "Pastore", "given": "Lucia", "initials": "L"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "European Influenza Surveillance Network", "given": "", "initials": ""}, {"family": "Members of the European Influenza Surveillance Network", "given": "", "initials": ""}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "40", "issn-l": null}, "abstract": "BackgroundAnnual seasonal influenza activity in the northern hemisphere causes a high burden of disease during the winter months, peaking in the first weeks of the year.AimWe describe the 2019/20 influenza season and the impact of the COVID-19 pandemic on sentinel surveillance in the World Health Organization (WHO) European Region.MethodsWe analysed weekly epidemiological and virological influenza data from sentinel primary care and hospital sources reported by countries, territories and areas (hereafter countries) in the European Region.ResultsWe observed co-circulation of influenza B/Victoria-lineage, A(H1)pdm09 and A(H3) viruses during the 2019/20 season, with different dominance patterns observed across the Region. A higher proportion of patients with influenza A virus infection than type B were observed. The influenza activity started in week 47/2019, and influenza positivity rate was \u2265 50% for 2 weeks (05-06/2020) rather than 5-8 weeks in the previous five seasons. In many countries a rapid reduction in sentinel reports and the highest influenza activity was observed in weeks 09-13/2020. Reporting was reduced from week 14/2020 across the Region coincident with the onset of widespread circulation of SARS-CoV-2.ConclusionsOverall, influenza type A viruses dominated; however, there were varying patterns across the Region, with dominance of B/Victoria-lineage viruses in a few countries. The COVID-19 pandemic contributed to an earlier end of the influenza season and reduced influenza virus circulation probably owing to restricted healthcare access and public health measures.", "doi": "10.2807/1560-7917.ES.2021.26.40.2100077", "pmid": "34622760", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:06:43.120Z", "modified": "2021-10-10T15:06:43.131Z"}, {"entity": "publication", "iuid": "52cf49fa75ee488785e083c10c6c9168", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/52cf49fa75ee488785e083c10c6c9168.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/52cf49fa75ee488785e083c10c6c9168"}}, "title": "Soluble angiotensin-converting enzyme 2 is transiently elevated in COVID-19 and correlates with specific inflammatory and endothelial markers.", "authors": [{"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A", "orcid": "0000-0003-1671-0827", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44c5053ce647424f8fd0c263dd655572.json"}}, {"family": "Ziegler", "given": "Louise", "initials": "L"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Rudberg", "given": "Ann-Sofie", "initials": "AS"}, {"family": "von Meijenfeldt", "given": "Fien", "initials": "F"}, {"family": "Lisman", "given": "Ton", "initials": "T"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Sand\u00e9n", "given": "Per", "initials": "P"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "J Med Virol", "issn": "1096-9071", "issn-l": null, "volume": "93", "issue": "10", "pages": "5908-5916"}, "abstract": "The main entry receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is angiotensin-converting enzyme 2 (ACE2). SARS-CoV-2 interactions with ACE2 may increase ectodomain shedding but consequences for the renin-angiotensin system and pathology in Coronavirus disease 2019 (COVID-19) remain unclear. We measured soluble ACE2 (sACE2) and sACE levels by enzyme-linked immunosorbent assay in 114 hospital-treated COVID-19 patients compared with 10 healthy controls; follow-up samples after four months were analyzed for 58 patients. Associations between sACE2 respectively sACE and risk factors for severe COVID-19, outcome, and inflammatory markers were investigated. Levels of sACE2 were higher in COVID-19 patients than in healthy controls, median 5.0 (interquartile range 2.8-11.8) ng/ml versus 1.4 (1.1-1.6) ng/ml, p < .0001. sACE2 was higher in men than women but was not affected by other risk factors for severe COVID-19. sACE2 decreased to 2.3 (1.6-3.9) ng/ml at follow-up, p < .0001, but remained higher than in healthy controls, p = .012. sACE was marginally lower during COVID-19 compared with at follow-up, 57 (45-70) ng/ml versus 72 (52-87) ng/ml, p = .008. Levels of sACE2 and sACE did not differ depending on survival or disease severity. sACE2 during COVID-19 correlated with von Willebrand factor, factor VIII and D-dimer, while sACE correlated with interleukin 6, tumor necrosis factor \u03b1, and plasminogen activator inhibitor 1. Conclusions: sACE2 was transiently elevated in COVID-19, likely due to increased shedding from infected cells. sACE2 and sACE during COVID-19 differed in correlations with markers of inflammation and endothelial dysfunction, suggesting release from different cell types and/or vascular beds.", "doi": "10.1002/jmv.27144", "pmid": "34138483", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC8426677"}], "notes": [], "created": "2021-06-28T18:38:59.230Z", "modified": "2021-12-12T18:08:59.955Z"}, {"entity": "publication", "iuid": "01ea523b4e384149a00f4668eae77d0b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01ea523b4e384149a00f4668eae77d0b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01ea523b4e384149a00f4668eae77d0b"}}, "title": "Serum Neurofilament Light is elevated in COVID-19 Positive Adults in the ICU and is associated with Co-Morbid Cardiovascular Disease, Neurological Complications, and Acuity of Illness.", "authors": [{"family": "Hay", "given": "Meredith", "initials": "M"}, {"family": "Ryan", "given": "Lee", "initials": "L"}, {"family": "Huentelman", "given": "Matthew", "initials": "M"}, {"family": "Konhilas", "given": "John", "initials": "J"}, {"family": "Hoyer-Kimura", "given": "Christina", "initials": "C"}, {"family": "Beach", "given": "Thomas G", "initials": "TG"}, {"family": "Serrano", "given": "Geidy E", "initials": "GE"}, {"family": "Reiman", "given": "Eric M", "initials": "EM"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Parthasarathy", "given": "Sairam", "initials": "S"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Cardiol Cardiovasc Med", "issn": "2572-9292", "volume": "5", "issue": "5", "pages": "551-565", "issn-l": null}, "abstract": "In critically ill COVID-19 patients, the risk of long-term neurological consequences is just beginning to be appreciated. While recent studies have identified that there is an increase in structural injury to the nervous system in critically ill COVID-19 patients, there is little known about the relationship of COVID-19 neurological damage to the systemic inflammatory diseases also observed in COVID-19 patients. The purpose of this pilot observational study was to examine the relationships between serum neurofilament light protein (NfL, a measure of neuronal injury) and co-morbid cardiovascular disease (CVD) and neurological complications in COVID-19 positive patients admitted to the intensive care unit (ICU). In this observational study of one-hundred patients who were admitted to the ICU in Tucson, Arizona between April and August 2020, 89 were positive for COVID-19 (COVID-pos) and 11 was COVID-negative (COVID-neg). A healthy control group (n=8) was examined for comparison. The primary outcomes and measures were subject demographics, serum NfL, presence and extent of CVD, diabetes, sequential organ failure assessment score (SOFA), presence of neurological complications, and blood chemistry panel data. COVID-pos patients in the ICU had significantly higher mean levels of Nfl (229.6 \u00b1 163 pg/ml) compared to COVID-neg ICU patients (19.3 \u00b1 5.6 pg/ml), Welch's t-test, p =.01 and healthy controls (12.3 \u00b1 3.1 pg/ml), Welch's t-test p =.005. Levels of Nfl in COVID-pos ICU patients were significantly higher in patients with concomitant CVD and diabetes (n=35, log Nfl 1.6\u00b1.09), and correlated with higher SOFA scores (r=.5, p =.001). These findings suggest that in severe COVID-19 disease, the central neuronal and axonal damage in these patients may be driven, in part, by the level of systemic cardiovascular disease and peripheral inflammation. Understanding the contributions of systemic inflammatory disease to central neurological degeneration in these COVID-19 survivors will be important to the design of interventional therapies to prevent long-term neurological and cognitive dysfunction.", "doi": "10.26502/fccm.92920221", "pmid": "34708189", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "mid", "key": "NIHMS1747952"}, {"db": "pmc", "key": "PMC8547787"}], "notes": [], "created": "2021-11-01T19:47:57.104Z", "modified": "2023-06-19T15:21:50.201Z"}, {"entity": "publication", "iuid": "9946b87cc5bd4651ae99d7288a850d43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9946b87cc5bd4651ae99d7288a850d43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9946b87cc5bd4651ae99d7288a850d43"}}, "title": "Sensing Inflammation Biomarkers with Electrolyte-Gated Organic Electronic Transistors.", "authors": [{"family": "Burtscher", "given": "Bernhard", "initials": "B", "orcid": "0000-0002-6394-2965", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/775b6ad4fdd94a49be50ac83e6fe8a95.json"}}, {"family": "Manco Urbina", "given": "Pamela Allison", "initials": "PA", "orcid": "0000-0002-3687-9374", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28ab31b512ad40de91c56fd73276984b.json"}}, {"family": "Diacci", "given": "Chiara", "initials": "C", "orcid": "0000-0002-2724-5601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa70b059609b44d8bf593f50cd699e52.json"}}, {"family": "Borghi", "given": "Simone", "initials": "S"}, {"family": "Pinti", "given": "Marcello", "initials": "M", "orcid": "0000-0001-9118-1262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10ebafa0cfa8439a8ffac27e8bdd120c.json"}}, {"family": "Cossarizza", "given": "Andrea", "initials": "A", "orcid": "0000-0002-5381-1558", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/916b3aa37d1744669bc10dd62e1cf8e7.json"}}, {"family": "Salvarani", "given": "Carlo", "initials": "C"}, {"family": "Berggren", "given": "Magnus", "initials": "M", "orcid": "0000-0001-5154-0291", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5fe2982d17543c480280343ade44a80.json"}}, {"family": "Biscarini", "given": "Fabio", "initials": "F", "orcid": "0000-0001-6648-5803", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e151476689844559964e691404f10b86.json"}}, {"family": "Simon", "given": "Daniel T", "initials": "DT", "orcid": "0000-0002-2799-3490", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21fd8689ce8c4a2fa58fb71b5118ae8b.json"}}, {"family": "Bortolotti", "given": "Carlo A", "initials": "CA", "orcid": "0000-0002-5701-5727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d460780d1154424e898f79de064fc43d.json"}}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Adv Healthc Mater", "issn": "2192-2659", "issn-l": null, "volume": "10", "issue": "20", "pages": "e2100955"}, "abstract": "An overview of cytokine biosensing is provided, with a focus on the opportunities provided by organic electronic platforms for monitoring these inflammation biomarkers which manifest at ultralow concentration levels in physiopathological conditions. Specifically, two of the field's state-of-the-art technologies-organic electrochemical transistors (OECTs) and electrolyte gated organic field effect transistors (EGOFETs)-and their use in sensing cytokines and other proteins associated with inflammation are a particular focus. The overview will include an introduction to current clinical and \"gold standard\" quantification techniques and their limitations in terms of cost, time, and required infrastructure. A critical review of recent progress with OECT- and EGOFET-based protein biosensors is presented, alongside a discussion onthe future of these technologies in the years and decades ahead. This is especially timely as the world grapples with limited healthcare diagnostics during the Coronavirus disease (COVID-19)pandemic where one of the worst-case scenarios for patients is the \"cytokine storm.\" Clearly, low-cost point-of-care technologies provided by OECTs and EGOFETs can ease the global burden on healthcare systems and support professionals by providing unprecedented wealth of data that can help to monitor disease progression in real time.", "doi": "10.1002/adhm.202100955", "pmid": "34423579", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-08-27T09:41:17.223Z", "modified": "2021-11-18T13:40:51.005Z"}, {"entity": "publication", "iuid": "fe3461dafb2240a49bb2996b40ff380c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fe3461dafb2240a49bb2996b40ff380c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fe3461dafb2240a49bb2996b40ff380c"}}, "title": "Parent-adolescent relationship quality as a moderator of links between COVID-19 disruption and reported changes in mothers' and young adults' adjustment in five countries.", "authors": [{"family": "Skinner", "given": "Ann T", "initials": "AT", "orcid": "0000-0001-8083-9487", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9bffc80b3a4b46789e77b9c9ea4203e6.json"}}, {"family": "Godwin", "given": "Jennifer", "initials": "J", "orcid": "0000-0001-5258-1351", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/abcc5b41ac7f4a7ebfebc17357ea4572.json"}}, {"family": "Alampay", "given": "Liane Pe\u00f1a", "initials": "LP", "orcid": "0000-0002-5760-6711", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39138bdb521f47d48ca20c6fd5097285.json"}}, {"family": "Lansford", "given": "Jennifer E", "initials": "JE", "orcid": "0000-0003-1956-4917", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/099f957450e743acab538878cc487a27.json"}}, {"family": "Bacchini", "given": "Dario", "initials": "D", "orcid": "0000-0001-6140-9377", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/087d86a987214e3e8b685b9dd31e4ccd.json"}}, {"family": "Bornstein", "given": "Marc H", "initials": "MH"}, {"family": "Deater-Deckard", "given": "Kirby", "initials": "K", "orcid": "0000-0003-4151-2152", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/211fa4b8046243e8b96ed9460dccd222.json"}}, {"family": "Di Giunta", "given": "Laura", "initials": "L"}, {"family": "Dodge", "given": "Kenneth A", "initials": "KA", "orcid": "0000-0001-5932-215X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68152786a6394d79b8261287f8020279.json"}}, {"family": "Gurdal", "given": "Sevtap", "initials": "S", "orcid": "0000-0001-7881-5670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3aa5a20191b040fc8d432e7deea46c90.json"}}, {"family": "Pastorelli", "given": "Concetta", "initials": "C", "orcid": "0000-0003-2837-7312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e126c726417442bafb6eb57680a7032.json"}}, {"family": "Sorbring", "given": "Emma", "initials": "E"}, {"family": "Steinberg", "given": "Laurence", "initials": "L"}, {"family": "Tapanya", "given": "Sombat", "initials": "S", "orcid": "0000-0002-2461-6593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eed362b8f81241e1a43f524c3f2b0c3d.json"}}, {"family": "Yotanyamaneewong", "given": "Saengduean", "initials": "S"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Dev Psychol", "issn": "1939-0599", "volume": "57", "issue": "10", "pages": "1648-1666", "issn-l": null}, "abstract": "The COVID-19 pandemic has presented families around the world with extraordinary challenges related to physical and mental health, economic security, social support, and education. The current study capitalizes on a longitudinal, cross-national study of parenting, adolescent development, and young adult competence to document the association between personal disruption during the pandemic and reported changes in internalizing and externalizing behavior in young adults and their mothers since the pandemic began. It further investigates whether family functioning during adolescence 3 years earlier moderates this association. Data from 484 families in five countries (Italy, the Philippines, Sweden, Thailand, and the United States) reveal that higher levels of reported disruption during the pandemic are related to reported increases in internalizing and externalizing behaviors after the onset of the COVID-19 pandemic for young adults (Mage = 20) and their mothers in all five countries, with the exception of one association in Thailand. Associations between disruption during the pandemic and young adults' and their mothers' reported increases in internalizing and externalizing behaviors were attenuated by higher levels of youth disclosure, more supportive parenting, and lower levels of destructive adolescent-parent conflict prior to the pandemic. This work has implications for fostering parent-child relationships characterized by warmth, acceptance, trust, open communication, and constructive conflict resolution at all times given their protective effects for family resilience during times of crisis. (PsycInfo Database Record (c) 2021 APA, all rights reserved).", "doi": "10.1037/dev0001236", "pmid": "34807687", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2022-06056-008"}], "notes": [], "created": "2021-11-26T13:55:20.287Z", "modified": "2021-11-26T13:55:20.643Z"}, {"entity": "publication", "iuid": "ec27250dd69044d38fecd673f5baf25d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec27250dd69044d38fecd673f5baf25d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec27250dd69044d38fecd673f5baf25d"}}, "title": "Organisational Response Strategies to COVID-19 in the Sharing Economy.", "authors": [{"family": "Mont", "given": "Oksana", "initials": "O"}, {"family": "Curtis", "given": "Steven Kane", "initials": "SK"}, {"family": "Voytenko Palgan", "given": "Yuliya", "initials": "Y"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Sustain Prod Consum", "issn": "2352-5509", "volume": "28", "pages": "52-70", "issn-l": null}, "abstract": "The COVID-19 pandemic has impacted production and consumption patterns across the world and forced many organisations to respond. However, there is a lack of understanding as to how sharing platforms have been affected by the pandemic, how they responded to the crisis, and what kinds of long-term implications the pandemic may have on the sharing economy. This study combined systematic literature review and qualitative web analysis of 30 mobility, space, and goods sharing platforms of different business models and geographies. An empirically-driven framework of organisational responses to COVID-19 was developed that comprises eight overarching response strategies targeting the organisation, users, and society. It is a novel framework that structures organisational responses to a high-impact, low-probability crisis. This study also discusses the long-term implications of the COVID-19 pandemic on the sharing economy, and explores how this may impact future responses among sharing platforms in the society that seeks sustainability. The learnings of this study have real-world significance. Sharing platforms can learn from each other about how to continue to respond in the face of the ongoing pandemic, and consider actions for future preparedness to potential forthcoming crises. With this we hope to encourage perseverance, long-term viability, sustainability, and resilience in organisations that may offer more sustainable ways of consumption and production.", "doi": "10.1016/j.spc.2021.03.025", "pmid": "34786447", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2352-5509(21)00098-1"}, {"db": "pmc", "key": "PMC8581630"}], "notes": [], "created": "2021-11-26T14:11:21.267Z", "modified": "2021-11-26T14:11:21.302Z"}, {"entity": "publication", "iuid": "4af14da35f39433b9b62419f6e6082e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4af14da35f39433b9b62419f6e6082e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4af14da35f39433b9b62419f6e6082e2"}}, "title": "Occupational risk of COVID-19 in the first versus second epidemic wave in Norway, 2020.", "authors": [{"family": "Magnusson", "given": "Karin", "initials": "K"}, {"family": "Nyg\u00e5rd", "given": "Karin", "initials": "K"}, {"family": "Methi", "given": "Fredrik", "initials": "F"}, {"family": "Vold", "given": "Line", "initials": "L"}, {"family": "Telle", "given": "Kjetil", "initials": "K"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "40", "issn-l": null}, "abstract": "BackgroundThe occupational risk of COVID-19 may be different in the first versus second epidemic wave.AimTo study whether employees in occupations that typically entail close contact with others were at higher risk of SARS-CoV-2 infection and COVID-19-related hospitalisation during the first and second epidemic wave before and after 18 July 2020, in Norway.MethodsWe included individuals in occupations working with patients, children, students, or customers using Standard Classification of Occupations (ISCO-08) codes. We compared residents (3,559,694 on 1 January 2020) in such occupations aged 20-70 years (mean: 44.1; standard deviation: 14.3 years; 51% men) to age-matched individuals in other professions using logistic regression adjusted for age, sex, birth country and marital status.ResultsNurses, physicians, dentists and physiotherapists had 2-3.5 times the odds of COVID-19 during the first wave when compared with others of working age. In the second wave, bartenders, waiters, food counter attendants, transport conductors, travel stewards, childcare workers, preschool and primary school teachers had ca 1.25-2 times the odds of infection. Bus, tram and taxi drivers had an increased odds of infection in both waves (odds ratio: 1.2-2.1). Occupation was of limited relevance for the odds of severe infection, here studied as hospitalisation with the disease.ConclusionOur findings from the entire Norwegian population may be of relevance to national and regional authorities in handling the epidemic. Also, we provide a knowledge foundation for more targeted future studies of lockdowns and disease control measures.", "doi": "10.2807/1560-7917.ES.2021.26.40.2001875", "pmid": "34622761", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:06:17.118Z", "modified": "2021-10-10T15:06:17.128Z"}, {"entity": "publication", "iuid": "9741f4d2903843baa47aa592053d5733", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9741f4d2903843baa47aa592053d5733.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9741f4d2903843baa47aa592053d5733"}}, "title": "Neurochemical biomarkers to study CNS effects of COVID-19: A narrative review and synthesis.", "authors": [{"family": "Ed\u00e9n", "given": "Arvid", "initials": "A", "orcid": "0000-0003-2817-9981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54411b4f4cbe422697c5eb3080c23e2c.json"}}, {"family": "Simr\u00e9n", "given": "Joel", "initials": "J", "orcid": "0000-0001-5081-6604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00690c8e16a545aea824cdf580837500.json"}}, {"family": "Price", "given": "Richard W", "initials": "RW"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e314740b02c344d2b336a9410e28041e.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "J Neurochem", "issn": "0022-3042", "issn-l": null, "volume": "159", "issue": "1", "pages": "61-77"}, "abstract": "Neurological symptoms are frequently reported in patients suffering from COVID-19. Common CNS-related symptoms include anosmia, caused by viral interaction with either neurons or supporting cells in nasal olfactory tissues. Diffuse encephalopathy is the most common sign of CNS dysfunction, which likely results from the CNS consequences of the systemic inflammatory syndrome associated with severe COVID-19. Additionally, microvascular injuries and thromboembolic events likely contribute to the neurologic impact of acute COVID-19. These observations are supported by evidence of CNS immune activation in cerebrospinal fluid (CSF) and in autopsy tissue, along with the detection of microvascular injuries in both pathological and neuroimaging studies. The frequent occurrence of thromboembolic events in patients with COVID-19 has generated different hypotheses, among which viral interaction with perivascular cells is particularly attractive, yet unproven. A distinguishing feature of CSF findings in SARS-CoV-2 infection is that clinical signs characteristic of neurotropic viral infections (CSF pleocytosis and blood-brain barrier injury) are mild or absent. Moreover, virus detection in CSF is rare and often of uncertain significance. In this review, we provide an overview of the neurological impact that occurs in the acute phase of COVID-19, and the role of CSF biomarkers in the clinical management and research to better treat and understand the disease. In addition to aiding as diagnostic and prognostic tools during acute infection, the use of comprehensive and well-characterized CSF and blood biomarkers will be vital in understanding the potential impact on the CNS in the rapidly increasing number of individuals recovering from COVID-19.", "doi": "10.1111/jnc.15459", "pmid": "34170549", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8420435"}], "notes": [], "created": "2021-06-28T18:12:28.285Z", "modified": "2023-06-19T14:46:17.609Z"}, {"entity": "publication", "iuid": "50547a0d81b74ad4b26b3bcc59ab4b29", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50547a0d81b74ad4b26b3bcc59ab4b29.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50547a0d81b74ad4b26b3bcc59ab4b29"}}, "title": "Increase in invasive disease caused by Haemophilus influenzae b, the Netherlands, 2020 to 2021.", "authors": [{"family": "Steens", "given": "Anneke", "initials": "A"}, {"family": "Stanoeva", "given": "Kamelia R", "initials": "KR"}, {"family": "Knol", "given": "Mirjam J", "initials": "MJ"}, {"family": "Mariman", "given": "Rob", "initials": "R"}, {"family": "de Melker", "given": "Hester E", "initials": "HE"}, {"family": "van Sorge", "given": "Nina M", "initials": "NM"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "42", "issn-l": null}, "abstract": "The incidence of most respiratory-transmitted diseases decreased during the COVID-19 pandemic as a result of containment measures. In contrast, in the Netherlands we noted an increase in invasive disease caused by Haemophilus influenzae b (Hib) (from < 0.3/100,000 before 2019 to 0.39 and 0.33/100,000 in 2020 and 2021) in vaccinated and unvaccinated age groups. We did not find a change in vaccine effectiveness against Hib invasive disease (effectiveness > 90%). We discuss factors that may have contributed to this rise.", "doi": "10.2807/1560-7917.ES.2021.26.42.2100956", "pmid": "34676819", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:12:02.433Z", "modified": "2021-10-26T18:12:02.449Z"}, {"entity": "publication", "iuid": "264e8f754e3946e2989b2a9c23cbe27b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/264e8f754e3946e2989b2a9c23cbe27b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/264e8f754e3946e2989b2a9c23cbe27b"}}, "title": "HMG-CoA reductase inhibitors and COVID-19 mortality in Stockholm, Sweden: A registry-based cohort study.", "authors": [{"family": "Bergqvist", "given": "Rita", "initials": "R"}, {"family": "Ahlqvist", "given": "Viktor H", "initials": "VH", "orcid": "0000-0003-1383-3194", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90ca532443fd48bf801018fc17345726.json"}}, {"family": "Lundberg", "given": "Michael", "initials": "M"}, {"family": "Hergens", "given": "Maria-Pia", "initials": "MP", "orcid": "0000-0001-5397-3541", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11f60a8ed4e849fab81602d86dce5819.json"}}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2c4588f000c470abf08f2e40852b6d1.json"}}, {"family": "Bell", "given": "Max", "initials": "M", "orcid": "0000-0001-7464-0324", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/530f7609a1f143b69691db5c41b14412.json"}}, {"family": "Magnusson", "given": "Cecilia", "initials": "C"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "PLoS Med", "issn": "1549-1676", "volume": "18", "issue": "10", "pages": "e1003820", "issn-l": "1549-1277"}, "abstract": "The relationship between statin treatment and Coronavirus Disease 2019 (COVID-19) mortality has been discussed due to the pleiotropic effects of statins on coagulation and immune mechanisms. However, available observational studies are hampered by study design flaws, resulting in substantial heterogeneity and ambiguities. Here, we aim to determine the relationship between statin treatment and COVID-19 mortality.\n\nThis cohort study included all Stockholm residents aged 45 or older (N = 963,876), followed up from 1 March 2020 until 11 November 2020. The exposure was statin treatment initiated before the COVID-19-pandemic, defined as recorded statin dispensation in the Swedish Prescribed Drug Register between 1 March 2019 and 29 February 2020. COVID-19-specific mortality was ascertained from the Swedish Cause of Death Registry. Hazard ratios (HRs) were calculated using multivariable Cox regression models. We further performed a target trial emulation restricted to initiators of statins. In the cohort (51.6% female), 169,642 individuals (17.6%) were statin users. Statin users were older (71.0 versus 58.0 years), more likely to be male (53.3% versus 46.7%), more often diagnosed with comorbidities (for example, ischemic heart disease 23.3% versus 1.6%), more frequently on anticoagulant and antihypertensive treatments, less likely to have a university-level education (34.5% versus 45.4%), and more likely to have a low disposable income (20.6% versus 25.2%), but less likely to reside in crowded housing (6.1% versus 10.3%). A total of 2,545 individuals died from COVID-19 during follow-up, including 765 (0.5%) of the statin users and 1,780 (0.2%) of the nonusers. Statin treatment was associated with a lowered COVID-19 mortality (adjusted HR, 0.88; 95% CI, 0.79 to 0.97, P = 0.01), and this association did not vary appreciably across age groups, sexes, or COVID-19 risk groups. The confounder adjusted HR for statin treatment initiators was 0.78 (95% CI, 0.59 to 1.05, P = 0.10) in the emulated target trial. Limitations of this study include the observational design, reliance on dispensation data, and the inability to study specific drug regimens.\n\nStatin treatment had a modest negative association with COVID-19 mortality. While this finding needs confirmation from randomized clinical trials, it supports the continued use of statin treatment for medical prevention according to current recommendations also during the COVID-19 pandemic.", "doi": "10.1371/journal.pmed.1003820", "pmid": "34648516", "labels": {"Category: Health": null, "Type: Journal article": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC8516243"}, {"db": "pii", "key": "PMEDICINE-D-21-02232"}], "notes": [], "created": "2021-10-21T05:06:28.806Z", "modified": "2023-01-13T14:42:42.766Z"}, {"entity": "publication", "iuid": "070a956c8f97485fbf74e03ed65eb838", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/070a956c8f97485fbf74e03ed65eb838.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/070a956c8f97485fbf74e03ed65eb838"}}, "title": "Factors for severe outcomes following SARS-CoV-2 infection in people with cystic fibrosis in Europe.", "authors": [{"family": "Jung", "given": "Andreas", "initials": "A", "orcid": "0000-0002-3505-6691", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00c3b50ae199470f9bbc3b6bab2a599d.json"}}, {"family": "Orenti", "given": "Annalisa", "initials": "A", "orcid": "0000-0002-0932-2757", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/962bc29291b04906a8412549987b427c.json"}}, {"family": "Dunlevy", "given": "Fiona", "initials": "F"}, {"family": "Aleksejeva", "given": "Elina", "initials": "E"}, {"family": "Bakkeheim", "given": "Egil", "initials": "E"}, {"family": "Bobrovnichy", "given": "Vladimir", "initials": "V"}, {"family": "Carr", "given": "Siobh\u00e1n B", "initials": "SB", "orcid": "0000-0003-0580-2478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37c62afad5b0418795bcc11860e944d5.json"}}, {"family": "Colombo", "given": "Carla", "initials": "C"}, {"family": "Corvol", "given": "Harriet", "initials": "H", "orcid": "0000-0002-7026-7523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3dc3bf5305094e88997c92b54ffda9b8.json"}}, {"family": "Cosgriff", "given": "Rebecca", "initials": "R"}, {"family": "Daneau", "given": "G\u00e9raldine", "initials": "G", "orcid": "0000-0002-2570-0893", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/352fa7a9aff1450691a070874ce7939a.json"}}, {"family": "Dogru", "given": "Deniz", "initials": "D", "orcid": "0000-0001-9931-9473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf97852882d74bd98670c8b89f743baa.json"}}, {"family": "Drevinek", "given": "Pavel", "initials": "P"}, {"family": "Vukic", "given": "Andrea Dugac", "initials": "AD"}, {"family": "Fajac", "given": "Isabelle", "initials": "I"}, {"family": "Fox", "given": "Alice", "initials": "A"}, {"family": "Fustik", "given": "Stojka", "initials": "S"}, {"family": "Gulmans", "given": "Vincent", "initials": "V"}, {"family": "Harutyunyan", "given": "Satenik", "initials": "S"}, {"family": "Hatziagorou", "given": "Elpis", "initials": "E"}, {"family": "Kasmi", "given": "Irena", "initials": "I"}, {"family": "Kayserov\u00e1", "given": "Hana", "initials": "H"}, {"family": "Kondratyeva", "given": "Elena", "initials": "E"}, {"family": "Krivec", "given": "Uro\u0161", "initials": "U", "orcid": "0000-0001-9031-5708", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c56e1173942d414f9bee9e0b7006273e.json"}}, {"family": "Makukh", "given": "Halyna", "initials": "H"}, {"family": "Malakauskas", "given": "Kestutis", "initials": "K"}, {"family": "McKone", "given": "Edward F", "initials": "EF"}, {"family": "Mei-Zahav", "given": "Meir", "initials": "M"}, {"family": "de Monestrol", "given": "Isabelle", "initials": "I"}, {"family": "Olesen", "given": "Hanne Vebert", "initials": "HV"}, {"family": "Padoan", "given": "Rita", "initials": "R"}, {"family": "Parulava", "given": "Tsitsino", "initials": "T", "orcid": "0000-0003-2467-7940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ef1c5c5029f47588fb30cbf14f2c597.json"}}, {"family": "Pastor-Vivero", "given": "Maria Dolores", "initials": "MD", "orcid": "0000-0001-8917-4709", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9014de29de4dab95548371cdc7e217.json"}}, {"family": "Pereira", "given": "Lu\u00edsa", "initials": "L"}, {"family": "Petrova", "given": "Guergana", "initials": "G"}, {"family": "Pfleger", "given": "Andreas", "initials": "A"}, {"family": "Pop", "given": "Liviu", "initials": "L"}, {"family": "van Rens", "given": "Jacqui G", "initials": "JG"}, {"family": "Rodic", "given": "Milan", "initials": "M"}, {"family": "Schlesser", "given": "Marc", "initials": "M"}, {"family": "Storms", "given": "Val\u00e9rie", "initials": "V", "orcid": "0000-0001-9344-0248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8126464b476e4745b3b2120dac24b72f.json"}}, {"family": "Turcu", "given": "Oxana", "initials": "O"}, {"family": "Woz Niacki", "given": "Lukasz", "initials": "L"}, {"family": "Yiallouros", "given": "Panayiotis", "initials": "P"}, {"family": "Zolin", "given": "Anna", "initials": "A"}, {"family": "Downey", "given": "Damian G", "initials": "DG"}, {"family": "Naehrlich", "given": "Lutz", "initials": "L"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "ERJ Open Res", "issn": "2312-0541", "volume": "7", "issue": "4", "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in people with cystic fibrosis (pwCF) can lead to severe outcomes.\n\nIn this observational study, the European Cystic Fibrosis Society Patient Registry collected data on pwCF and SARS-CoV-2 infection to estimate incidence, describe clinical presentation and investigate factors associated with severe outcomes using multivariable analysis.\n\nUp to December 31, 2020, 26 countries reported information on 828 pwCF and SARS-CoV-2 infection. Incidence was 17.2 per 1000 pwCF (95% CI: 16.0-18.4). Median age was 24 years, 48.4% were male and 9.4% had lung transplants. SARS-CoV-2 incidence was higher in lung-transplanted (28.6; 95% CI: 22.7-35.5) versus non-lung-transplanted pwCF (16.6; 95% CI: 15.4-17.8) (p\u22640.001).SARS-CoV-2 infection caused symptomatic illness in 75.7%. Factors associated with symptomatic SARS-CoV-2 infection were age >40 years, at least one F508del mutation and pancreatic insufficiency.Overall, 23.7% of pwCF were admitted to hospital, 2.5% of those to intensive care, and regretfully 11 (1.4%) died. Hospitalisation, oxygen therapy, intensive care, respiratory support and death were 2- to 6-fold more frequent in lung-transplanted versus non-lung-transplanted pwCF.Factors associated with hospitalisation and oxygen therapy were lung transplantation, cystic fibrosis-related diabetes (CFRD), moderate or severe lung disease and azithromycin use (often considered a surrogate marker for Pseudomonas aeruginosa infection and poorer lung function).\n\nSARS-CoV-2 infection yielded high morbidity and hospitalisation in pwCF. PwCF with forced expiratory volume in 1 s <70% predicted, CFRD and those with lung transplants are at particular risk of more severe outcomes.", "doi": "10.1183/23120541.00411-2021", "pmid": "34984210", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00411-2021"}, {"db": "pmc", "key": "PMC8557394"}], "notes": [], "created": "2022-01-10T15:34:09.247Z", "modified": "2022-01-10T15:34:09.603Z"}, {"entity": "publication", "iuid": "23e85d99f304475997ae98f01d623822", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23e85d99f304475997ae98f01d623822.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23e85d99f304475997ae98f01d623822"}}, "title": "Envisioning a resilient future for biodiversity conservation in the wake of the COVID-19 pandemic.", "authors": [{"family": "Thurstan", "given": "Ruth H", "initials": "RH", "orcid": "0000-0002-8045-1631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fcb1b48a6fa348d1b0a06f61557d25c2.json"}}, {"family": "Hockings", "given": "Kimberley J", "initials": "KJ", "orcid": "0000-0002-6187-644X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6488f4e007a4830a82eb835a00e807d.json"}}, {"family": "Hedlund", "given": "Johanna S U", "initials": "JSU", "orcid": "0000-0001-5826-9588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8ef2989b3e746898de804b994d7dce5.json"}}, {"family": "Bersacola", "given": "Elena", "initials": "E", "orcid": "0000-0003-3814-8687", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2043264a8a3433e8b7bca33dee4382d.json"}}, {"family": "Collins", "given": "Claire", "initials": "C", "orcid": "0000-0001-8651-7219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d94fde481994e4f8d0214e4b3a08f76.json"}}, {"family": "Early", "given": "Regan", "initials": "R", "orcid": "0000-0003-4108-5904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6de473963b89421bb2904cc6345af2b7.json"}}, {"family": "Ermiasi", "given": "Yunsiska", "initials": "Y"}, {"family": "Fleischer-Dogley", "given": "Frauke", "initials": "F"}, {"family": "Gilkes", "given": "Gabriella", "initials": "G"}, {"family": "Harrison", "given": "Mark E", "initials": "ME", "orcid": "0000-0002-0729-8407", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc453216906d43b4b6139edf47a8ce95.json"}}, {"family": "Imron", "given": "Muhammad Ali", "initials": "MA", "orcid": "0000-0003-2371-7795", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e3434f5422842ffbb00a3cc22eb6f46.json"}}, {"family": "Kaiser-Bunbury", "given": "Christopher N", "initials": "CN", "orcid": "0000-0001-7254-3491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02a818e22a9440dea2df7ffd2a0732c6.json"}}, {"family": "Refly Katoppo", "given": "Daniel", "initials": "D"}, {"family": "Marriott", "given": "Cheryl", "initials": "C"}, {"family": "Muzungaile", "given": "Marie-May", "initials": "M"}, {"family": "Nuno", "given": "Ana", "initials": "A", "orcid": "0000-0003-4680-2378", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f710f96931dc49cda3b9949632fc6a7a.json"}}, {"family": "Regalla de Barros", "given": "Aissa", "initials": "A"}, {"family": "van Veen", "given": "Frank", "initials": "F", "orcid": "0000-0003-0708-5492", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/372d44cb6cf541228033a0d8ae879bf7.json"}}, {"family": "Wijesundara", "given": "Isuru", "initials": "I", "orcid": "0000-0001-8200-458X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52efefa366fc403fb63908c962e9e373.json"}}, {"family": "Dogley", "given": "Didier", "initials": "D"}, {"family": "Bunbury", "given": "Nancy", "initials": "N", "orcid": "0000-0002-5836-5497", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7427d5c15b5c44ef807df90170dca752.json"}}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "People Nat (Hoboken)", "issn": "2575-8314", "issn-l": null, "volume": "3", "issue": "5", "pages": "990-1013"}, "abstract": "As the COVID-19 pandemic continues to affect societies across the world, the ongoing economic and social disruptions are likely to present fundamental challenges for current and future biodiversity conservation.We review the literature for outcomes of past major societal, political, economic and zoonotic perturbations on biodiversity conservation, and demonstrate the complex implications of perturbation events upon conservation efforts. Building on the review findings, we use six in-depth case studies and the emerging literature to identify positive and negative outcomes of the COVID-19 pandemic, known and anticipated, for biodiversity conservation efforts around the world.A number of similarities exist between the current pandemic and past perturbations, with experiences highlighting that the pandemic-induced declines in conservation revenue and capacity, livelihood and trade disruptions are likely to have long-lasting and negative implications for biodiversity and conservation efforts.Yet, the COVID-19 pandemic also brought about a global pause in human movement that is unique in recent history, and may yet foster long-lasting behavioural and societal changes, presenting opportunities to strengthen and advance conservation efforts in the wake of the pandemic. Enhanced collaborations and partnerships at the local level, cross-sectoral engagement, local investment and leadership will all enhance the resilience of conservation efforts in the face of future perturbations. Other actions aimed at enhancing resilience will require fundamental institutional change and extensive government and public engagement and support if they are to be realised.The pandemic has highlighted the inherent vulnerabilities in the social and economic models upon which many conservation efforts are based. In so doing, it presents an opportunity to reconsider the status quo for conservation, and promotes behaviours and actions that are resilient to future perturbation. A free Plain Language Summary can be found within the Supporting Information of this article.", "doi": "10.1002/pan3.10262", "pmid": "34909607", "labels": {"Type: Review": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PAN310262"}, {"db": "pmc", "key": "PMC8661774"}], "notes": [], "created": "2021-12-18T17:50:19.313Z", "modified": "2022-02-17T10:13:54.308Z"}, {"entity": "publication", "iuid": "f4b78ade978c41bf8c14690408b3b554", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f4b78ade978c41bf8c14690408b3b554.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f4b78ade978c41bf8c14690408b3b554"}}, "title": "Diabetes, hypertension, body mass index, smoking and COVID-19-related mortality: a systematic review and meta-analysis of observational studies", "authors": [{"family": "Mahamat-Saleh", "given": "Yahya", "initials": "Y", "orcid": "0000-0002-5892-8886", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9ac3af0c6f044d1b10c29683467d030.json"}}, {"family": "Fiolet", "given": "Thibault", "initials": "T"}, {"family": "Rebeaud", "given": "Mathieu Edouard", "initials": "ME"}, {"family": "Mulot", "given": "Matthieu", "initials": "M"}, {"family": "Guihur", "given": "Anthony", "initials": "A", "orcid": "0000-0001-5353-1428", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9949ce6f1c3744e1b127ab415b2a7470.json"}}, {"family": "El Fatouhi", "given": "Douae", "initials": "D"}, {"family": "Laouali", "given": "Nasser", "initials": "N"}, {"family": "Peiffer-Smadja", "given": "Nathan", "initials": "N"}, {"family": "Aune", "given": "Dagfinn", "initials": "D", "orcid": "0000-0002-4533-1722", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3d9e8a2005a4e6fa5fe266389bf80c0.json"}}, {"family": "Severi", "given": "Gianluca", "initials": "G"}], "type": "journal-article", "published": "2021-10-00", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "10", "pages": "e052777"}, "abstract": null, "doi": "10.1136/bmjopen-2021-052777", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:33:43.138Z", "modified": "2022-02-17T09:57:52.122Z"}, {"entity": "publication", "iuid": "84bae0b622bf41e7ab85af7ea3fd45a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84bae0b622bf41e7ab85af7ea3fd45a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84bae0b622bf41e7ab85af7ea3fd45a4"}}, "title": "Cross-sectional examination of 24-hour movement behaviours among 3- and 4-year-old children in urban and rural settings in low-income, middle-income and high-income countries: the SUNRISE study protocol", "authors": [{"family": "Okely", "given": "Tony", "initials": "T"}, {"family": "Reilly", "given": "John J", "initials": "JJ"}, {"family": "Tremblay", "given": "Mark S", "initials": "MS"}, {"family": "Kariippanon", "given": "Katharina E", "initials": "KE", "orcid": "0000-0003-4269-682X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cdb4f12289b34e8593ad5727870ef08c.json"}}, {"family": "Draper", "given": "Catherine E", "initials": "CE"}, {"family": "El Hamdouchi", "given": "Asmaa", "initials": "A"}, {"family": "Florindo", "given": "Alex A", "initials": "AA"}, {"family": "Green", "given": "Janette P", "initials": "JP"}, {"family": "Guan", "given": "Hongyan", "initials": "H"}, {"family": "Katzmarzyk", "given": "Peter T", "initials": "PT"}, {"family": "Lubree", "given": "Himangi", "initials": "H"}, {"family": "Pham", "given": "Bang Nguyen", "initials": "BN"}, {"family": "Suesse", "given": "Thomas", "initials": "T"}, {"family": "Willumsen", "given": "Juana", "initials": "J"}, {"family": "Basheer", "given": "Mohamed", "initials": "M"}, {"family": "Calleia", "given": "Rebecca", "initials": "R"}, {"family": "Chong", "given": "Kar Hau", "initials": "KH"}, {"family": "Cross", "given": "Penny L", "initials": "PL"}, {"family": "Nacher", "given": "Maria", "initials": "M"}, {"family": "Smeets", "given": "Laura", "initials": "L"}, {"family": "Taylor", "given": "Ellie", "initials": "E"}, {"family": "Abdeta", "given": "Chalchisa", "initials": "C"}, {"family": "Aguilar-Farias", "given": "Nicolas", "initials": "N"}, {"family": "Baig", "given": "Aqsa", "initials": "A"}, {"family": "Bayasgalan", "given": "Jambaldori", "initials": "J"}, {"family": "Chan", "given": "Cecilia H S", "initials": "CHS"}, {"family": "Chathurangana", "given": "P W Prasad", "initials": "PWP"}, {"family": "Chia", "given": "Michael", "initials": "M"}, {"family": "Ghofranipour", "given": "Fazlollah", "initials": "F"}, {"family": "Ha", "given": "Amy S", "initials": "AS"}, {"family": "Hossain", "given": "Mohammad Sorowar", "initials": "MS"}, {"family": "Janssen", "given": "Xanne", "initials": "X"}, {"family": "J\u00e1uregui", "given": "Alejandra", "initials": "A"}, {"family": "Katewongsa", "given": "Piyawat", "initials": "P"}, {"family": "Kim", "given": "Dong Hoon", "initials": "DH"}, {"family": "Kim", "given": "Thanh Van", "initials": "TV"}, {"family": "Koh", "given": "Denise", "initials": "D"}, {"family": "Kontsevaya", "given": "Anna", "initials": "A", "orcid": "0000-0003-2062-1536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c23c67bbbc043aea62ee98370a94ba8.json"}}, {"family": "Leyna", "given": "Germana H", "initials": "GH"}, {"family": "L\u00f6f", "given": "M", "initials": "M"}, {"family": "Munambah", "given": "Nyaradzai", "initials": "N"}, {"family": "Mwase-Vuma", "given": "Tawonga", "initials": "T"}, {"family": "Nusurupia", "given": "Jackline", "initials": "J"}, {"family": "Oluwayomi", "given": "Aoko", "initials": "A"}, {"family": "del Pozo-Cruz", "given": "Borja", "initials": "B"}, {"family": "del Pozo-Cruz", "given": "Jesus", "initials": "J"}, {"family": "Roos", "given": "Eva", "initials": "E"}, {"family": "Shirazi", "given": "Asima", "initials": "A"}, {"family": "Singh", "given": "Pragya", "initials": "P"}, {"family": "Staiano", "given": "Amanda", "initials": "A"}, {"family": "Suherman", "given": "Adang", "initials": "A"}, {"family": "Tanaka", "given": "Chiaki", "initials": "C"}, {"family": "Tang", "given": "Hong Kim", "initials": "HK"}, {"family": "Teo", "given": "Wei Peng", "initials": "WP"}, {"family": "Tiongco", "given": "Marites M", "initials": "MM"}, {"family": "Tladi", "given": "Dawn", "initials": "D"}, {"family": "Turab", "given": "Ali", "initials": "A"}, {"family": "Veldman", "given": "Sanne L C", "initials": "SLC"}, {"family": "Webster", "given": "E Kipling", "initials": "EK"}, {"family": "Wickramasinghe", "given": "Pujitha", "initials": "P"}, {"family": "Widyastari", "given": "Dyah Anantalia", "initials": "DA"}], "type": "journal-article", "published": "2021-10-00", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "10", "pages": "e049267"}, "abstract": null, "doi": "10.1136/bmjopen-2021-049267", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:33:09.365Z", "modified": "2022-02-17T09:46:28.556Z"}, {"entity": "publication", "iuid": "7e8ac1a37684451792822dcb03dc7c4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e8ac1a37684451792822dcb03dc7c4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e8ac1a37684451792822dcb03dc7c4c"}}, "title": "Characteristics and Outcomes of Over 300,000 Patients with COVID-19 and History of Cancer in the United States and Spain.", "authors": [{"family": "Roel", "given": "Elena", "initials": "E", "orcid": "0000-0002-1964-3546", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad1d9cc65d3242339540f938eeceafe1.json"}}, {"family": "Pistillo", "given": "Andrea", "initials": "A", "orcid": "0000-0002-4467-0220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/055156368b8845a0bfdc522a53cc1b0d.json"}}, {"family": "Recalde", "given": "Martina", "initials": "M", "orcid": "0000-0003-2256-618X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a41e082476aa464484b65418923ad81e.json"}}, {"family": "Sena", "given": "Anthony G", "initials": "AG", "orcid": "0000-0001-8630-5347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9202e069d9c24646b006b6abb640b541.json"}}, {"family": "Fern\u00e1ndez-Bertol\u00edn", "given": "Sergio", "initials": "S"}, {"family": "Arag\u00f3n", "given": "Maria", "initials": "M"}, {"family": "Puente", "given": "Diana", "initials": "D"}, {"family": "Ahmed", "given": "Waheed-Ul-Rahman", "initials": "WU", "orcid": "0000-0003-0880-0355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27d074e0c92342d299e693d12173356c.json"}}, {"family": "Alghoul", "given": "Heba", "initials": "H", "orcid": "0000-0001-8234-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e3deb1abdf54088a29dee7675a18697.json"}}, {"family": "Alser", "given": "Osaid", "initials": "O", "orcid": "0000-0001-6743-803X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c919eb8e21f74327b80f25eae0313eb6.json"}}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM", "orcid": "0000-0002-5630-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5162aab03bc04dafa809108461f18667.json"}}, {"family": "Areia", "given": "Carlos", "initials": "C", "orcid": "0000-0002-4668-7069", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7232f54be5df43f0b984d0117d88a054.json"}}, {"family": "Blacketer", "given": "Clair", "initials": "C", "orcid": "0000-0003-2570-2124", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a325a8031ace41ed905c1c64b22fc653.json"}}, {"family": "Carter", "given": "William", "initials": "W"}, {"family": "Casajust", "given": "Paula", "initials": "P", "orcid": "0000-0003-2733-5436", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8a3feb959bd461c8c4ad81fcd9dee8b.json"}}, {"family": "Culhane", "given": "Aedin C", "initials": "AC", "orcid": "0000-0002-1395-9734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11a2209eca25401e9870f7b75f66df67.json"}}, {"family": "Dawoud", "given": "Dalia", "initials": "D", "orcid": "0000-0002-2105-1937", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e25c9903cd364cd5a14a32554f63c9da.json"}}, {"family": "DeFalco", "given": "Frank", "initials": "F"}, {"family": "DuVall", "given": "Scott L", "initials": "SL", "orcid": "0000-0002-4898-3865", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd524264c46548cf861123d43d57151a.json"}}, {"family": "Falconer", "given": "Thomas", "initials": "T"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Gong", "given": "Mengchun", "initials": "M"}, {"family": "Hester", "given": "Laura", "initials": "L", "orcid": "0000-0002-4593-1293", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a77277f84d5e433b849001f3287ee330.json"}}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Tan", "given": "Eng Hooi", "initials": "EH", "orcid": "0000-0003-4470-2736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72566a67becb42cab02d274915d24737.json"}}, {"family": "Jeon", "given": "Hokyun", "initials": "H"}, {"family": "Jonnagaddala", "given": "Jitendra", "initials": "J", "orcid": "0000-0002-9912-2344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8403290b9ec43fe93b558de97d84559.json"}}, {"family": "Lai", "given": "Lana Y H", "initials": "LYH", "orcid": "0000-0002-0485-0956", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc15faacca7f4857b5c7babef24ffaf4.json"}}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Natarajan", "given": "Karthik", "initials": "K"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Ostropolets", "given": "Anna", "initials": "A", "orcid": "0000-0002-0847-6682", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f642e577d2445a3a7ce873b42d0c479.json"}}, {"family": "Posada", "given": "Jos\u00e9 D", "initials": "JD"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A", "orcid": "0000-0003-1202-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47f086bb6ccd49a2a5f11a32c06277c8.json"}}, {"family": "Reich", "given": "Christian G", "initials": "CG"}, {"family": "Rivera", "given": "Donna R", "initials": "DR", "orcid": "0000-0002-4565-4556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40627463ecc34b9896787a9a71e3dbad.json"}}, {"family": "Schilling", "given": "Lisa M", "initials": "LM", "orcid": "0000-0002-6878-189X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7888233862b04fce978bb44ece6ccb19.json"}}, {"family": "Soerjomataram", "given": "Isabelle", "initials": "I"}, {"family": "Shah", "given": "Karishma", "initials": "K", "orcid": "0000-0002-6219-1653", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d792a1c7704b4093a3835642181f0865.json"}}, {"family": "Shah", "given": "Nigam H", "initials": "NH", "orcid": "0000-0001-9385-7158", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4aca07eb2cd948c3b736c30cb3f3b6e6.json"}}, {"family": "Shen", "given": "Yang", "initials": "Y"}, {"family": "Spotniz", "given": "Matthew", "initials": "M"}, {"family": "Subbian", "given": "Vignesh", "initials": "V"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Trama", "given": "Annalisa", "initials": "A", "orcid": "0000-0001-8220-9833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b54a2d0430e4ab783fcc82d8c9f8786.json"}}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhang", "given": "Ying", "initials": "Y"}, {"family": "Ryan", "given": "Patrick B", "initials": "PB"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Kostka", "given": "Kristin", "initials": "K", "orcid": "0000-0003-2595-8736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9675cf1b775341f6a3521c7dde950262.json"}}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T", "orcid": "0000-0002-8274-0357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11fd8deb257445e7a93a0a3098b246df.json"}}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Cancer Epidemiol Biomarkers Prev", "issn": "1538-7755", "volume": "30", "issue": "10", "pages": "1884-1894", "issn-l": null}, "abstract": "We described the demographics, cancer subtypes, comorbidities, and outcomes of patients with a history of cancer and coronavirus disease 2019 (COVID-19). Second, we compared patients hospitalized with COVID-19 to patients diagnosed with COVID-19 and patients hospitalized with influenza.\n\nWe conducted a cohort study using eight routinely collected health care databases from Spain and the United States, standardized to the Observational Medical Outcome Partnership common data model. Three cohorts of patients with a history of cancer were included: (i) diagnosed with COVID-19, (ii) hospitalized with COVID-19, and (iii) hospitalized with influenza in 2017 to 2018. Patients were followed from index date to 30 days or death. We reported demographics, cancer subtypes, comorbidities, and 30-day outcomes.\n\nWe included 366,050 and 119,597 patients diagnosed and hospitalized with COVID-19, respectively. Prostate and breast cancers were the most frequent cancers (range: 5%-18% and 1%-14% in the diagnosed cohort, respectively). Hematologic malignancies were also frequent, with non-Hodgkin's lymphoma being among the five most common cancer subtypes in the diagnosed cohort. Overall, patients were aged above 65 years and had multiple comorbidities. Occurrence of death ranged from 2% to 14% and from 6% to 26% in the diagnosed and hospitalized COVID-19 cohorts, respectively. Patients hospitalized with influenza (n = 67,743) had a similar distribution of cancer subtypes, sex, age, and comorbidities but lower occurrence of adverse events.\n\nPatients with a history of cancer and COVID-19 had multiple comorbidities and a high occurrence of COVID-19-related events. Hematologic malignancies were frequent.\n\nThis study provides epidemiologic characteristics that can inform clinical care and etiologic studies.", "doi": "10.1158/1055-9965.EPI-21-0266", "pmid": "34272262", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8974356"}, {"db": "pii", "key": "1055-9965.EPI-21-0266"}], "notes": [], "created": "2023-01-13T09:52:18.710Z", "modified": "2023-06-19T15:34:44.126Z"}, {"entity": "publication", "iuid": "a8edb57968704d61b7823bc613afbe4e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8edb57968704d61b7823bc613afbe4e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8edb57968704d61b7823bc613afbe4e"}}, "title": "COVID19 Disease Map, a computational knowledge repository of virus-host interaction mechanisms.", "authors": [{"family": "Ostaszewski", "given": "Marek", "initials": "M", "orcid": "0000-0003-1473-370X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad3ed3c26f8a4e49aa8edb0bba8ecb19.json"}}, {"family": "Niarakis", "given": "Anna", "initials": "A", "orcid": "0000-0002-9687-7426", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b96190acb1dd484a83a74afc41fd3c8c.json"}}, {"family": "Mazein", "given": "Alexander", "initials": "A", "orcid": "0000-0001-7137-4171", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2efd5e320ebf44e3a1b8847088b7eae7.json"}}, {"family": "Kuperstein", "given": "Inna", "initials": "I", "orcid": "0000-0001-8086-8915", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43f6315d46434416b8183e06a91084f3.json"}}, {"family": "Phair", "given": "Robert", "initials": "R", "orcid": "0000-0001-7979-2386", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44c205f1ef1a496b8dbdce7fd42c15c0.json"}}, {"family": "Orta-Resendiz", "given": "Aurelio", "initials": "A", "orcid": "0000-0002-6632-883X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53d9ab13209746ada1c3ca163c6c4807.json"}}, {"family": "Singh", "given": "Vidisha", "initials": "V", "orcid": "0000-0002-3250-6669", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/289debcdb0ee477a8c5ea140bb982742.json"}}, {"family": "Aghamiri", "given": "Sara Sadat", "initials": "SS", "orcid": "0000-0003-4440-7059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a27c186dd609468cbe5fdaf53453c8ae.json"}}, {"family": "Acencio", "given": "Marcio Luis", "initials": "ML", "orcid": "0000-0002-8278-240X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7a8ea6189a64d088e7303ec2362fc53.json"}}, {"family": "Glaab", "given": "Enrico", "initials": "E", "orcid": "0000-0003-3977-7469", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ac2ddf4b2f24e89bc6181099aeaf422.json"}}, {"family": "Ruepp", "given": "Andreas", "initials": "A", "orcid": "0000-0003-1705-3515", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc9fc4ee13f04a3ead276fa82d4b6de3.json"}}, {"family": "Fobo", "given": "Gisela", "initials": "G"}, {"family": "Montrone", "given": "Corinna", "initials": "C"}, {"family": "Brauner", "given": "Barbara", "initials": "B"}, {"family": "Frishman", "given": "Goar", "initials": "G"}, {"family": "Monraz G\u00f3mez", "given": "Luis Crist\u00f3bal", "initials": "LC"}, {"family": "Somers", "given": "Julia", "initials": "J", "orcid": "0000-0001-9489-2246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b48974bc51204f63875b9efd092bc1bd.json"}}, {"family": "Hoch", "given": "Matti", "initials": "M", "orcid": "0000-0002-2486-0246", "researcher": {"href": 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"https://publications-covid19.scilifelab.se/researcher/568efa35a020457b90f3f313d004dd58.json"}}, {"family": "Ponce de Leon", "given": "Miguel", "initials": "M", "orcid": "0000-0002-7496-844X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9fe25b6b14ae4521a63c615fa6142075.json"}}, {"family": "Funahashi", "given": "Akira", "initials": "A", "orcid": "0000-0003-0605-239X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d17761419d74a31b088c3bd101c1df3.json"}}, {"family": "Hiki", "given": "Yusuke", "initials": "Y", "orcid": "0000-0001-6955-3867", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8977c92272dd4699873a2bc2ab5d8c86.json"}}, {"family": "Hiroi", "given": "Noriko", "initials": "N", "orcid": "0000-0002-0214-373X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4aff05ff5feb424f8884803732142a91.json"}}, {"family": "Yamada", "given": "Takahiro G", "initials": "TG", "orcid": "0000-0002-1665-1778", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bacf1beecd94f8b99cf8f4279660a56.json"}}, {"family": "Dr\u00e4ger", "given": "Andreas", "initials": "A", "orcid": "0000-0002-1240-5553", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/846ba169210444f2816b6b9ab616169e.json"}}, {"family": "Renz", "given": "Alina", "initials": "A", "orcid": "0000-0003-3851-9978", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6fec830968244a7bbceacd4a6de8e56c.json"}}, {"family": "Naveez", "given": "Muhammad", "initials": "M", "orcid": "0000-0003-2437-2055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dfe41d31a2ca4cdfb4ffdc9336313a03.json"}}, {"family": "Bocskei", "given": "Zsolt", "initials": "Z", "orcid": "0000-0002-6105-2504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39081a56066543189b92ebf3f8d461fa.json"}}, 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"https://publications-covid19.scilifelab.se/researcher/2b82bd1326364f20b99c31bc4c87c928.json"}}, {"family": "Pico", "given": "Alexander R", "initials": "AR", "orcid": "0000-0001-5706-2163", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f0c2f9e7ae342b091262f25e50074b6.json"}}, {"family": "Evelo", "given": "Chris T", "initials": "CT", "orcid": "0000-0002-5301-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2dd7e54b2c56497a834ee9e803ee76d5.json"}}, {"family": "Gillespie", "given": "Marc E", "initials": "ME", "orcid": "0000-0002-5766-1702", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9ccfe4704504a99873bd800e86e59be.json"}}, {"family": "Stein", "given": "Lincoln D", "initials": "LD", "orcid": "0000-0002-1983-4588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e7d7a39c24c40f99f00639a9fdab10c.json"}}, {"family": "Hermjakob", "given": "Henning", "initials": "H", "orcid": "0000-0001-8479-0262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89303e87266b44fbaf33a811713257cd.json"}}, {"family": "D'Eustachio", "given": "Peter", "initials": "P", "orcid": "0000-0002-5494-626X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53d33c1e054540b8b8730e913dbb282b.json"}}, {"family": "Saez-Rodriguez", "given": "Julio", "initials": "J", "orcid": "0000-0002-8552-8976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/95931a9232ee4e82b01252e9ab31e8cd.json"}}, {"family": "Dopazo", "given": "Joaquin", "initials": "J", "orcid": "0000-0003-3318-120X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7701cf5d39f4d6cb455cd27ace48bb0.json"}}, {"family": "Valencia", "given": "Alfonso", "initials": "A", "orcid": "0000-0002-8937-6789", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9877cbb9a124eb0b99b5e1d8cde4752.json"}}, {"family": "Kitano", "given": "Hiroaki", "initials": "H", "orcid": "0000-0002-3589-1953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e945269c001427b9cce60f288d8c3bc.json"}}, {"family": "Barillot", "given": "Emmanuel", "initials": "E", "orcid": "0000-0003-2724-2002", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/601bf39565aa494dbf347a8f6af6d9c9.json"}}, {"family": "Auffray", "given": "Charles", "initials": "C", "orcid": "0000-0003-2226-7411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/653a07414125471a991ac5733bc1cfea.json"}}, {"family": "Balling", "given": "Rudi", "initials": "R", "orcid": "0000-0003-2902-5650", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e72fef5ff024aa0bc2cd5bf02add22f.json"}}, {"family": "Schneider", "given": "Reinhard", "initials": "R", "orcid": "0000-0002-8278-1618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/16d96bb94cd34671aa3f30868e37d6c7.json"}}, {"family": "COVID-19 Disease Map Community", "given": "", "initials": ""}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Mol Syst Biol", "issn": "1744-4292", "volume": "17", "issue": "10", "pages": "e10387", "issn-l": "1744-4292"}, "abstract": "We need to effectively combine the knowledge from surging literature with complex datasets to propose mechanistic models of SARS-CoV-2 infection, improving data interpretation and predicting key targets of intervention. Here, we describe a large-scale community effort to build an open access, interoperable and computable repository of COVID-19 molecular mechanisms. The COVID-19 Disease Map (C19DMap) is a graphical, interactive representation of disease-relevant molecular mechanisms linking many knowledge sources. Notably, it is a computational resource for graph-based analyses and disease modelling. To this end, we established a framework of tools, platforms and guidelines necessary for a multifaceted community of biocurators, domain experts, bioinformaticians and computational biologists. The diagrams of the C19DMap, curated from the literature, are integrated with relevant interaction and text mining databases. We demonstrate the application of network analysis and modelling approaches by concrete examples to highlight new testable hypotheses. This framework helps to find signatures of SARS-CoV-2 predisposition, treatment response or prioritisation of drug candidates. Such an approach may help deal with new waves of COVID-19 or similar pandemics in the long-term perspective.", "doi": "10.15252/msb.202110387", "pmid": "34664389", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-21T04:54:54.498Z", "modified": "2021-10-21T04:54:57.857Z"}, {"entity": "publication", "iuid": "a2ac4ed89b574e36a58271d2411b0d88", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2ac4ed89b574e36a58271d2411b0d88.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2ac4ed89b574e36a58271d2411b0d88"}}, "title": "COVID-19 and handwashing: Implications for water use in Sub-Saharan Africa.", "authors": [{"family": "Amuakwa-Mensah", "given": "Franklin", "initials": "F"}, {"family": "Klege", "given": "Rebecca Afua", "initials": "RA"}, {"family": "Adom", "given": "Philip Kofi", "initials": "PK"}, {"family": "K\u00f6hlin", "given": "Gunnar", "initials": "G"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Water Resour Econ", "issn": "2212-4284", "volume": "36", "pages": "100189", "issn-l": null}, "abstract": "Because the main modes of transmission of the COVID-19 virus are respiration and contact, WHO recommends frequent washing of hands with soap under running water for at least 20 s. This article investigates how the level of concern about COVID-19 affects the likelihood of washing hands frequently in sub-Saharan Africa. We discuss the implication of the findings for water-scarce environment. The study makes use of a unique survey dataset from 12 sub-Saharan African countries collected in April 2020 (first round) and May 2020 (second round) and employs an extended ordered probit model with endogenous covariate. The results show that the level of concern about the spread of the virus increases the likelihood of washing hands with soap under running water for a minimum of 20 s at least five times a day. The increase in the probability of handwashing due to concern about COVID-19, ranges from 3% for Benin to 6.3% for South Africa. The results also show heterogeneous effects across gender- and age-groups, locality and various water sources. However, in Africa, the sustainability of the handwashing protocol could be threatened by the severe water scarcity that exists in the region. To sustain frequent handwashing, sub-Saharan Africa needs an effective strategy for water management and supply.", "doi": "10.1016/j.wre.2021.100189", "pmid": "34745865", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2212-4284(21)00013-X"}, {"db": "pmc", "key": "PMC8563594"}], "notes": [], "created": "2021-11-26T15:34:51.447Z", "modified": "2021-11-26T15:34:51.482Z"}, {"entity": "publication", "iuid": "eb5532c9c30840e7ae31b631e10eb2ac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb5532c9c30840e7ae31b631e10eb2ac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb5532c9c30840e7ae31b631e10eb2ac"}}, "title": "Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19.", "authors": [{"family": "Aamodt", "given": "Anne Hege", "initials": "AH", "orcid": "0000-0002-2824-2760", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b21211bae394fef867be93f162d8ef8.json"}}, {"family": "H\u00f8gest\u00f8l", "given": "Einar August", "initials": "EA", "orcid": "0000-0001-8446-2111", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be2ccda7a98243e78919d6e58629b5cf.json"}}, {"family": "Popperud", "given": "Trine Haug", "initials": "TH"}, {"family": "Holter", "given": "Jan Cato", "initials": "JC", "orcid": "0000-0003-1618-5022", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7b6512c252a422badaaa120ee2aa700.json"}}, {"family": "Dyrhol-Riise", "given": "Anne Ma", "initials": "AM", "orcid": "0000-0003-4009-4032", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/051b91855a064394a525b898992aa834.json"}}, {"family": "Tonby", "given": "Kristian", "initials": "K", "orcid": "0000-0002-8465-1315", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dee8c27f3f184a52aaf4b1a82c0efe0e.json"}}, {"family": "Stiksrud", "given": "Birgitte", "initials": "B", "orcid": "0000-0001-9679-8181", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd511102a315446cb0fcef7e1a5b4f7b.json"}}, {"family": "Quist-Paulsen", "given": "Else", "initials": "E", "orcid": "0000-0002-1633-5660", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93114d4a49524fb4af2479a8ec268365.json"}}, {"family": "Berge", "given": "Tone", "initials": "T", "orcid": "0000-0002-5297-2034", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bae2754b3324238a3d36933f0b2d001.json"}}, {"family": "Barratt-Due", "given": "Andreas", "initials": "A", "orcid": "0000-0001-5408-7162", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f6cdc11b90949d2b825b76eee88333b.json"}}, {"family": "Aukrust", "given": "P\u00e5l", "initials": "P", "orcid": "0000-0002-6509-6221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e946d8e631c46f6b9613c7f73755e6d.json"}}, {"family": "Heggelund", "given": "Lars", "initials": "L", "orcid": "0000-0002-1669-1032", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9befa124c647487d803e8dba68495821.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/351fab09f6e24b9f9e6695da83947cb6.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e314740b02c344d2b336a9410e28041e.json"}}, {"family": "Harbo", "given": "Hanne Flinstad", "initials": "HF", "orcid": "0000-0002-6047-0122", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90fa41f3df4b40df903efcacad11b947.json"}}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "J Neurol", "issn": "1432-1459", "volume": "268", "issue": "10", "pages": "3574-3583", "issn-l": null}, "abstract": "To test the hypotheses that blood biomarkers for nervous system injury, serum concentrations of neurofilament light chain protein (NfL) and glial fibrillary acidic protein (GFAp) can serve as biomarkers for disease severity in COVID-19 patients.\n\nForty-seven inpatients with confirmed COVID-19 had blood samples drawn on admission for assessing serum biomarkers of CNS injury by Single molecule array (Simoa), NfL and GFAp. Concentrations of NfL and GFAp were analyzed in relation to symptoms, clinical signs, inflammatory biomarkers and clinical outcomes. We used multivariate linear models to test for differences in biomarker concentrations in the subgroups, accounting for confounding effects.\n\nIn total, 21% (n = 10) of the patients were admitted to an intensive care unit, and the overall mortality rate was 13% (n = 6). Non-survivors had higher serum concentrations of NfL (p < 0.001) upon admission than patients who were discharged alive both in adjusted analyses (p = 2.6 \u00d7 10-7) and unadjusted analyses (p = 0.001). The concentrations of NfL in non-survivors increased over repeated measurements; whereas, the concentrations in survivors were stable. The GFAp concentration was also significantly higher in non-survivors than survivors (p = 0.02).\n\nIncreased concentrations of NfL and GFAp in COVID-19 patients on admission may indicate increased mortality risk. Measurement of blood biomarkers for nervous system injury can be useful to detect and monitor CNS injury in COVID-19.", "doi": "10.1007/s00415-021-10517-6", "pmid": "33743046", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7980743"}, {"db": "pii", "key": "10.1007/s00415-021-10517-6"}], "notes": [], "created": "2021-03-22T10:17:46.101Z", "modified": "2023-06-19T14:57:19.636Z"}, {"entity": "publication", "iuid": "c66d19afa22c45fd98d6bf059cb208d8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c66d19afa22c45fd98d6bf059cb208d8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c66d19afa22c45fd98d6bf059cb208d8"}}, "title": "Biomarkers for central nervous system injury in cerebrospinal fluid are elevated in COVID-19 and associated with neurological symptoms and disease severity.", "authors": [{"family": "Virhammar", "given": "Johan", "initials": "J", "orcid": "0000-0001-9901-2949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9db4ac69a3e8495ea8e71ae60042fa5c.json"}}, {"family": "N\u00e4\u00e4s", "given": "Anja", "initials": "A"}, {"family": "F\u00e4llmar", "given": "David", "initials": "D"}, {"family": "Cunningham", "given": "Janet L", "initials": "JL"}, {"family": "Klang", "given": "Andrea", "initials": "A"}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ"}, {"family": "Jackmann", "given": "Sven", "initials": "S"}, {"family": "Westman", "given": "Gabriel", "initials": "G"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Rostami", "given": "Elham", "initials": "E"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Eur J Neurol", "issn": "1468-1331", "issn-l": null, "volume": "28", "issue": "10", "pages": "3324-3331"}, "abstract": "Neurological symptoms have been frequently reported in hospitalized patients with coronavirus disease 2019 (COVID-19), and biomarkers of central nervous system (CNS) injury are reported to be increased in plasma but not extensively studied in cerebrospinal fluid (CSF). This study examined CSF for biomarkers of CNS injury and other pathology in relation to neurological symptoms and disease severity in patients with neurological manifestations of COVID-19.\n\nNineteen patients with neurological symptoms and mild to critical COVID-19 were prospectively included. Extensive analysis of CSF, including measurement of biomarkers of CNS injury (neurofilament light chain [NfL] protein, glial fibrillary acidic protein [GFAp], and total tau), was performed and compared to neurological features and disease severity.\n\nNeurological symptoms included altered mental status (42%), headache (42%), and central (21%) and peripheral weakness (32%). Two patients demonstrated minor pleocytosis, and four patients had increased immunoglobulin G levels in CSF. Neuronal autoantibody testing using commercial tests was negative in all patients. Increased CSF levels of NfL protein, total tau, and GFAp were seen in 63%, 37%, and 16% of patients, respectively. Increased NfL protein correlated with disease severity, time in intensive care, and level of consciousness. NfL protein in CSF was higher in patients with central neurological symptoms.\n\nAlthough limited by the small sample size, our data suggest that levels of NfL protein, GFAp, and total tau in CSF are commonly elevated in patients with COVID-19 with neurological symptoms. This is in contrast to the standard CSF workup where pathological findings are scarce. NfL protein, in particular, is associated with central neurological symptoms and disease severity.", "doi": "10.1111/ene.14703", "pmid": "33369818", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8518988"}], "notes": [], "created": "2021-01-07T13:15:08.321Z", "modified": "2021-12-12T18:06:16.091Z"}, {"entity": "publication", "iuid": "2b1f786eed0c4282b1e2f6ae144bf76d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b1f786eed0c4282b1e2f6ae144bf76d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b1f786eed0c4282b1e2f6ae144bf76d"}}, "title": "A longitudinal study on symptom duration and 60-day clinical course in non-hospitalised COVID-19 cases in Berlin, Germany, March to May, 2020.", "authors": [{"family": "Saad", "given": "Neil J", "initials": "NJ"}, {"family": "Moek", "given": "Felix", "initials": "F"}, {"family": "Steitz", "given": "Fabienne", "initials": "F"}, {"family": "Murajda", "given": "Lukas", "initials": "L"}, {"family": "B\u00e4rnighausen", "given": "Till", "initials": "T"}, {"family": "Zoller", "given": "Thomas", "initials": "T"}, {"family": "P\u00f6rtner", "given": "Kirsten", "initials": "K"}, {"family": "Muller", "given": "Nadine", "initials": "N"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "43", "issn-l": null}, "abstract": "BackgroundDetailed information on symptom duration and temporal course of patients with mild COVID-19 was scarce at the beginning of the COVID-19 pandemic.AimWe aimed to determine the longitudinal course of clinical symptoms in non-hospitalised COVID-19 patients in Berlin, Germany.MethodsBetween March and May 2020, 102 confirmed COVID-19 cases in home isolation notified in Berlin, Germany, were sampled using total population sampling. Data on 25 symptoms were collected during telephone consultations (a maximum of four consultations) with each patient. We collected information on prevalence and duration of symptoms for each day of the first 2 weeks after symptom onset and for day 30 and 60 after symptom onset.ResultsMedian age was 35 years (range 18-74), 57% (58/102) were female, and 37% (38/102) reported having comorbidities. During the first 2 weeks, most common symptoms were malaise (94%, 92/98), headache (71%, 70/98), and rhinitis (69%, 68/98). Malaise was present for a median of 11 days (IQR 7-14 days) with 35% (34/98) of cases still reporting malaise on day 14. Headache and muscle pain mostly occurred during the first week, whereas dysosmia and dysgeusia mostly occurred during the second week. Symptoms persisted in 41% (39/95) and 20% (18/88) of patients on day 30 and 60, respectively.ConclusionOur study shows that a significant proportion of non-hospitalised COVID-19 cases endured symptoms for at least 2 months. Further research is needed to assess the frequency of long-term adverse health effects in non-hospitalised COVID-19 patients.", "doi": "10.2807/1560-7917.ES.2021.26.43.2001757", "pmid": "34713798", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:51:46.148Z", "modified": "2021-11-01T19:51:46.163Z"}, {"entity": "publication", "iuid": "3ed4dababe18432292a120455da77843", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ed4dababe18432292a120455da77843.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ed4dababe18432292a120455da77843"}}, "title": "The Upper Respiratory Tract of Felids Is Highly Susceptible to SARS-CoV-2 Infection.", "authors": [{"family": "Kr\u00fcger", "given": "Nadine", "initials": "N", "orcid": "0000-0002-4413-8699", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/397f978cad79487e89676dc30b50f227.json"}}, {"family": "Rocha", "given": "Cheila", "initials": "C", "orcid": "0000-0002-0148-9405", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c49cd1df09cb49399d87e33722f400e8.json"}}, {"family": "Runft", "given": "Sandra", "initials": "S"}, {"family": "Kr\u00fcger", "given": "Johannes", "initials": "J"}, {"family": "F\u00e4rber", "given": "Iris", "initials": "I", "orcid": "0000-0002-3390-5880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61e578b4819a415d9db7daef5d2a8c55.json"}}, {"family": "Armando", "given": "Federico", "initials": "F"}, {"family": "Leitzen", "given": "Eva", "initials": "E", "orcid": "0000-0002-3818-9246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44e86d0862104a4aae31c94715ca130b.json"}}, {"family": "Brogden", "given": "Graham", "initials": "G", "orcid": "0000-0002-2306-7932", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3015adaef844c0bad26d535324e19d9.json"}}, {"family": "Gerold", "given": "Gisa", "initials": "G", "orcid": "0000-0002-1326-5038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39af3df98cf14f96baa155798617841b.json"}}, {"family": "P\u00f6hlmann", "given": "Stefan", "initials": "S", "orcid": "0000-0001-6086-9136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03c63bbe69c949748dc5ecd3ec438492.json"}}, {"family": "Hoffmann", "given": "Markus", "initials": "M", "orcid": "0000-0003-4603-7696", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b40ee42e4354ca99c33a2633bbbaed4.json"}}, {"family": "Baumg\u00e4rtner", "given": "Wolfgang", "initials": "W"}], "type": "journal article", "published": "2021-09-30", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "22", "issue": "19", "issn-l": null}, "abstract": "Natural or experimental infection of domestic cats and virus transmission from humans to captive predatory cats suggest that felids are highly susceptible to SARS-CoV-2 infection. However, it is unclear which cells and compartments of the respiratory tract are infected. To address this question, primary cell cultures derived from the nose, trachea, and lungs of cat and lion were inoculated with SARS-CoV-2. Strong viral replication was observed for nasal mucosa explants and tracheal air-liquid interface cultures, whereas replication in lung slices was less efficient. Infection was mainly restricted to epithelial cells and did not cause major pathological changes. Detection of high ACE2 levels in the nose and trachea but not lung further suggests that susceptibility of feline tissues to SARS-CoV-2 correlates with ACE2 expression. Collectively, this study demonstrates that SARS-CoV-2 can efficiently replicate in the feline upper respiratory tract ex vivo and thus highlights the risk of SARS-CoV-2 spillover from humans to felids.", "doi": "10.3390/ijms221910636", "pmid": "34638978", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijms221910636"}, {"db": "pmc", "key": "PMC8508926"}], "notes": [], "created": "2021-10-21T05:28:18.673Z", "modified": "2021-10-21T05:28:50.620Z"}, {"entity": "publication", "iuid": "d6dbde36b7d041d087bdd5e48bddf97a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d6dbde36b7d041d087bdd5e48bddf97a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d6dbde36b7d041d087bdd5e48bddf97a"}}, "title": "Global Prevalence of Adaptive and Prolonged Infections\u2019 Mutations in the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein", "authors": [{"family": "Lennerstrand", "given": "Johan", "initials": "J"}, {"family": "Palanisamy", "given": "Navaneethan", "initials": "N", "orcid": "0000-0003-0369-2316", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e92f0f2edcb4c8eaa66f55c59490717.json"}}], "type": "journal-article", "published": "2021-09-30", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "10", "pages": "1974", "issn-l": "1999-4915"}, "abstract": null, "doi": "10.3390/v13101974", "pmid": null, "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:30:11.056Z", "modified": "2021-10-26T18:30:11.115Z"}, {"entity": "publication", "iuid": "e6ae64a793f84661ac387675c53ac24e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6ae64a793f84661ac387675c53ac24e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6ae64a793f84661ac387675c53ac24e"}}, "title": "An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responses.", "authors": [{"family": "Mangsbo", "given": "Sara M", "initials": "SM", "orcid": "0000-0002-1355-2678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cf494629d8a4f9584ada4be16dff66b.json"}}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Laur\u00e9n", "given": "Ida", "initials": "I"}, {"family": "Lindsay", "given": "Robin", "initials": "R", "orcid": "0000-0001-7867-8653", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf1f32f9550141fb8c4ebbb0cbe09e51.json"}}, {"family": "Jernbom Falk", "given": "August", "initials": "A", "orcid": "0000-0002-7773-1851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40d944d7fa964f4292f10012356a2730.json"}}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Lord", "given": "Martin", "initials": "M", "orcid": "0000-0002-3238-3187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ddcd91137ed4f8c88b2beb2db340081.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "D\u00f6nnes", "given": "Pierre", "initials": "P"}, {"family": "Christoffersson", "given": "Gustaf", "initials": "G"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "evaluation study", "published": "2021-09-30", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "9", "pages": "e0258041"}, "abstract": "Numerous assays evaluating serological and cellular responses have been developed to characterize immune responses against SARS-CoV-2. Serological assays are both cost- and time-effective compared to cellular assays, but cellular immune responses may provide a diagnostic value to determine previous SARS-CoV-2 infection in seronegative individuals. However, potential cross-reactive T cell responses stemming from prior encounters with human coronaviruses (HCoVs) may affect assay specificity. In this study, we evaluated the specificity and sensitivity of a SARS-CoV-2 IFN-\u03b3 Release Assay (IGRA) based on the FluoroSpot method employing commercially available SARS-CoV-2-specific peptide pools, as well as an in-house designed SARS-CoV-2 peptide pool restricted to 5 amino acid stretches or less aligning with endemic HCoVs. Blood samples were obtained from healthcare workers (HCW) 5-6 months post SARS-CoV-2 spike (S) IgG and nucleocapsid (N) IgG dual seroconversion (n = 187) and HCW who had been S IgG and N IgG dual seronegative at repeated occasions, including the current sampling time point (n = 102). In addition, samples were obtained 4 to 5 months post infection from 55 polymerase chain reaction (PCR)-confirmed COVID-19 patients. Assay specificity and sensitivity were calculated with serology as a reference standard for HCW. The in-house generated peptide pool displayed a specificity of 96.1%, while the commercially available peptide pools displayed specificities of 80.4% and 85.3%, respectively. Sensitivity was higher in a cohort of previously hospitalized COVID-19 patients (96.4% and 84.0% for the commercially available peptide pools and 92.7% for the in-house generated peptide pool) compared to the HCW cohort (92.0% and 66.8% for the commercially available peptide pools and 76.0% for the in-house generated peptide pool). Based on these findings, the individual diagnostic value of T cell immune responses against SARS-CoV-2 currently appears to be limited but remain an important research tool ahead.", "doi": "10.1371/journal.pone.0258041", "pmid": "34591918", "labels": {"Category: Imaging": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-19070"}, {"db": "pmc", "key": "PMC8483319"}], "notes": [], "created": "2021-11-18T15:12:02.239Z", "modified": "2021-11-19T10:47:39.135Z"}, {"entity": "publication", "iuid": "6f7064f617d945d68996fc33dbc10b00", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f7064f617d945d68996fc33dbc10b00.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f7064f617d945d68996fc33dbc10b00"}}, "title": "SARS-CoV-2 integral membrane proteins shape the serological responses of COVID-19 patients.", "authors": [{"family": "Martin", "given": "Sophie", "initials": "S"}, {"family": "Heslan", "given": "Christopher", "initials": "C"}, {"family": "J\u00e9gou", "given": "Gw\u00e9na\u00eble", "initials": "G"}, {"family": "Eriksson", "given": "Leif A", "initials": "LA"}, {"family": "Le Gallo", "given": "Matthieu", "initials": "M"}, {"family": "Thibault", "given": "Vincent", "initials": "V"}, {"family": "Chevet", "given": "Eric", "initials": "E"}, {"family": "Godey", "given": "Florence", "initials": "F"}, {"family": "Avril", "given": "Tony", "initials": "T"}], "type": "journal article", "published": "2021-09-29", "journal": {"title": "iScience", "issn": "2589-0042", "pages": "103185", "issn-l": "2589-0042"}, "abstract": "SARS-CoV-2 pandemic has elicited a unique mobilization of the scientific community to develop efficient tools to understand and combat infection. Like other coronavirae, SARS-CoV-2 hijacks host cell secretory machinery to produce viral proteins that compose the nascent virions; including Spike (S), Envelope (E) and Membrane (M) proteins, the most exposed transmembrane proteins to the host immune system. As antibody response is part of the anti-viral immune arsenal, we investigate the immunogenic potential of S, E and M using a human cell-based system to mimic membrane insertion and N-glycosylation. Both S and M elicit specific Ig production in SARS-CoV-2 patients. Patients with moderate and severe diseases exhibit elevated Ig responses. Finally, reduced Ig binding was observed with Spike G614 compared to D614 variant. Altogether, our assay points towards an unexpected immune response against M and represents a powerful tool to test humoral responses against actively evolving SARS-CoV-2 variants and vaccine effectiveness.", "doi": "10.1016/j.isci.2021.103185", "pmid": "34604721", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(21)01153-6"}, {"db": "pmc", "key": "PMC8479324"}, {"db": "URL", "key": "https://data.mendeley.com/datasets/69tvkst9ct/1", "description": "clinical and raw data related to serological assay"}], "notes": [], "created": "2021-10-11T17:56:55.960Z", "modified": "2021-10-15T07:54:32.174Z"}, {"entity": "publication", "iuid": "b2e64a7af9894313b4e54453e26ffae7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b2e64a7af9894313b4e54453e26ffae7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b2e64a7af9894313b4e54453e26ffae7"}}, "title": "High level of protection against COVID-19 after two doses of BNT162b2 vaccine in the working age population \u2013 first results from a cohort study in Southern Sweden", "authors": [{"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J", "orcid": "0000-0003-1883-2000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e88fdca336ae41c891f0a46e2481b67f.json"}}, {"family": "Inghammar", "given": "Malin", "initials": "M", "orcid": "0000-0003-2995-1312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4ab710428614cccb2a537ecab31d0a0.json"}}, {"family": "Moghaddassi", "given": "Mahnaz", "initials": "M", "orcid": "0000-0002-0844-4736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a219bde5ba8a4f3f8655ada08d749885.json"}}, {"family": "Rasmussen", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1588-5473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c760e8d21ae441ba236f86e6185d392.json"}}, {"family": "Malmqvist", "given": "Ulf", "initials": "U"}, {"family": "Kahn", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-5566-6350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42eda71f3775400599febc10a4e7359c.json"}}], "type": "journal-article", "published": "2021-09-29", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4235", "issn-l": null, "volume": null, "issue": null, "pages": "1-6"}, "abstract": "Vaccine effectiveness against COVID-19 needs to be assessed in diverse real-world population settings.\n\nA cohort study of 805,741 residents in Sk\u00e5ne county, Southern Sweden, aged 18-64 years, of whom 26,587 received at least one dose of the BNT162b2 vaccine. Incidence rates of COVID-19 were estimated in sex- and age-adjusted analysis and stratified in two-week periods with substantial community spread of the disease.\n\nThe estimated vaccine effectiveness in preventing infection \u22657 days after second dose was 86% (95% CI 72-94%) but only 42% (95% CI 14-63%) \u226514 days after a single dose. No difference in vaccine effectiveness was observed between females and males. Having a prior positive test was associated with 91% (95% CI 85-94%) effectiveness against new infection among the unvaccinated.\n\nA satisfactory effectiveness of BNT162b2 after the second dose was suggested, but with possibly substantially lower effect before the second dose.", "doi": "10.1080/23744235.2021.1982144", "pmid": "34586934", "labels": {"Category: Biochemistry": null, "Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null, "Funder: VR": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC8500302"}], "notes": [], "created": "2021-10-11T18:09:45.592Z", "modified": "2021-11-29T06:13:18.964Z"}, {"entity": "publication", "iuid": "80e9261113314fb7856ca4ae73f8dc27", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/80e9261113314fb7856ca4ae73f8dc27.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/80e9261113314fb7856ca4ae73f8dc27"}}, "title": "Solidarity and polarisation regarding COVID-19 and related risks - A thematic analysis of comments from an international survey.", "authors": [{"family": "Stjernsw\u00e4rd", "given": "Sigrid", "initials": "S"}, {"family": "Glasdam", "given": "Stinne", "initials": "S"}], "type": "journal article", "published": "2021-09-28", "journal": {"title": "Soc Sci Humanit Open", "issn": "2590-2911", "volume": "4", "issue": "1", "pages": "100211", "issn-l": null}, "abstract": "COVID-19 represents a risk to people's life and societies in their current shapes and functions, with institutionalised responses redefining everyday life. Crises in society can induce fear and tensions that can unite and divide people, inducing acts of solidarity and polarisation. The study explored articulations of solidarity and polarisation in relation to the COVID-19 pandemic and related risks. A Foucault-inspired thematic analysis was pursued on qualitative data from an international survey about COVID-19 and social media. The analysis resulted in four themes illustrating articulations of solidarity and polarisation related to the COVID-19 pandemic. The analysis showed solidarity and polarisation as each other's premise and contradiction. Socialisation into a 'new normal' was characterised by the balance between solidarity and polarisation as well as aspirations to enhance future solidarity. The study illustrated that social media functioned as social technology for control and manipulation towards social normalisation. However, it was also used to voice attempts to rectify (or overthrow) the dominant medico-political discourse and norms with own preferences, opinions and a functioning daily life. In short, the articulations and social media uses could be interpreted as expressions of power and counter-power.", "doi": "10.1016/j.ssaho.2021.100211", "pmid": "34604736", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2590-2911(21)00107-8"}, {"db": "pmc", "key": "PMC8479510"}], "notes": [], "created": "2021-10-11T17:56:21.609Z", "modified": "2021-10-11T17:56:21.646Z"}, {"entity": "publication", "iuid": "321676cd0e76407a9091ffc38c3adc4e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/321676cd0e76407a9091ffc38c3adc4e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/321676cd0e76407a9091ffc38c3adc4e"}}, "title": "Risk for SARS-CoV-2 infection in healthcare workers outside hospitals: A real-life immuno-virological study during the first wave of the COVID-19 epidemic.", "authors": [{"family": "Fr\u00f6berg", "given": "Maria", "initials": "M"}, {"family": "Hassan", "given": "Sadaf Sakina", "initials": "SS"}, {"family": "Pimenoff", "given": "Ville N", "initials": "VN"}, {"family": "Akterin", "given": "Susanne", "initials": "S"}, {"family": "Conneryd Lundgren", "given": "Kalle", "initials": "K"}, {"family": "Elfstr\u00f6m", "given": "K Miriam", "initials": "KM"}, {"family": "Dillner", "given": "Joakim", "initials": "J", "orcid": "0000-0001-8588-6506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bbb8b0ca5dc648e0b80c1de224b26c69.json"}}], "type": "journal article", "published": "2021-09-28", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "9", "pages": "e0257854", "issn-l": "1932-6203"}, "abstract": "Most COVID-19 related infections and deaths may occur in healthcare outside hospitals. Here we explored SARS-CoV-2 infections among healthcare workers (HCWs) in this setting.\n\nAll healthcare providers in Stockholm, Sweden were asked to recruit HCWs at work for a study of past or present SARS-CoV-2 infections among HCWs. Study participants This study reports the results from 839 HCWs, mostly employees of primary care centers, sampled in June 2020.\n\nSARS-CoV-2 seropositivity was found among 12% (100/839) of HCWs, ranging from 0% to 29% between care units. Seropositivity decreased by age and was highest among HCWs <40 years of age. Within this age group there was 19% (23/120) seropositivity among women and 11% (15/138) among men (p<0.02). Current infection, as measured using PCR, was found in only 1% and the typical testing pattern of pre-symptomatic potential \"superspreaders\" found in only 2/839 subjects.\n\nPrevious SARS-CoV-2 infections were common among younger HCWs in this setting. Pre-symptomatic infection was uncommon, in line with the strong variability in SARS-CoV-2 exposure between units. Prioritizing infection prevention and control including sufficient and adequate personal protective equipment, and vaccination for all HCWs are important to prevent nosocomial infections and infections as occupational injuries during an ongoing pandemic.", "doi": "10.1371/journal.pone.0257854", "pmid": "34582483", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-17200"}, {"db": "pmc", "key": "PMC8478233"}], "notes": [], "created": "2021-10-11T18:07:24.488Z", "modified": "2021-10-11T18:07:24.511Z"}, {"entity": "publication", "iuid": "b63a0c526c9045eb9f4dddb326b2f5f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b63a0c526c9045eb9f4dddb326b2f5f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b63a0c526c9045eb9f4dddb326b2f5f2"}}, "title": "Post-Traumatic Stress Disorder in Chinese Teachers during COVID-19 Pandemic: Roles of Fear of COVID-19, Nomophobia, and Psychological Distress.", "authors": [{"family": "Kukreti", "given": "Shikha", "initials": "S", "orcid": "0000-0002-8370-3988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d0daa4b90a164aaa8acfc4f1cebb7fd3.json"}}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK", "orcid": "0000-0003-0530-8138", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d442447b551649d8a5372c6bf0075c91.json"}}, {"family": "Strong", "given": "Carol", "initials": "C"}, {"family": "Chen", "given": "I-Hua", "initials": "I"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Ko", "given": "Nai-Ying", "initials": "N"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Chen", "given": "Yu-Pin", "initials": "Y"}, {"family": "Kuo", "given": "Yi-Jie", "initials": "Y"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-09-28", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "issn-l": null, "volume": "9", "issue": "10", "pages": null}, "abstract": "There are limited data concerning the prevalence of post-traumatic stress disorder (PTSD) among teachers. Therefore, the present study estimated the prevalence of PTSD among mainland Chinese teachers during the COVID-19 pandemic and to construct a model with mediation and moderation effects to explain the PTSD. Data collection was conducted in schools in the Jiangxi province between October and November 2020 among k-12 schoolteachers. An online survey, including five different psychometric scales, was used to collect data. All participants were assessed for PTSD using the Chinese version of the PTSD Checklist for DSM-5 (PCL-5). Hayes' PROCESS Model 8 was used to examine the potential factors explaining a higher PTSD scores. A total of 2603 teachers from k-12 schools participated. With the cutoff score at 31, the prevalence of PTSD was 12.3% but decreased to 1.0% when the cutoff score was at 49. Nomophobia moderated the effects of Fear of COVID-19 Scale on PTSD. The findings suggest that fear of COVID-19 among teachers leads to PTSD via psychological distress, highlighting the moderating effect of nomophobia in this association. Based on the study's findings, psychological interventions and educational training are needed to reduce fear among teachers at higher risk of developing PTSD.", "doi": "10.3390/healthcare9101288", "pmid": "34682968", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "healthcare9101288"}], "notes": [], "created": "2021-10-26T18:17:05.359Z", "modified": "2022-02-17T09:44:49.441Z"}, {"entity": "publication", "iuid": "18ed2ce5f25849da929c9e365ae4ec05", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18ed2ce5f25849da929c9e365ae4ec05.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18ed2ce5f25849da929c9e365ae4ec05"}}, "title": "A Retrospective Cross-Sectional Study Assessing Self-Reported Adverse Events following Immunization (AEFI) of the COVID-19 Vaccine in Bangladesh", "authors": [{"family": "Sultana", "given": "Arifa", "initials": "A", "orcid": "0000-0002-5855-8731", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b70e8f78af140dcb43d8c1ecf01232f.json"}}, {"family": "Shahriar", "given": "Saimon", "initials": "S", "orcid": "0000-0003-1460-3104", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f11efd633e6460a89dc1737e21c2fec.json"}}, {"family": "Tahsin", "given": "Md Rafat", "initials": "MR"}, {"family": "Mim", "given": "Sabiha Rahman", "initials": "SR"}, {"family": "Fatema", "given": "Kazi Rubiya", "initials": "KR", "orcid": "0000-0002-8368-0798", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f98d252b78e643d48f24a19d85c94d65.json"}}, {"family": "Saha", "given": "Ananya", "initials": "A"}, {"family": "Yesmin", "given": "Fahmida", "initials": "F"}, {"family": "Bahar", "given": "Nasiba Binte", "initials": "NB", "orcid": "0000-0002-5981-3220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3407484c9fc419eaccb9eff656148cc.json"}}, {"family": "Samodder", "given": "Mithun", "initials": "M", "orcid": "0000-0001-6057-7838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09d49d33289245208488f07cd60cc1c4.json"}}, {"family": "Mamun", "given": "Md Ariful Haque", "initials": "MAH", "orcid": "0000-0002-9123-5272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9c66bede129447b95970d7679c0dbce.json"}}, {"family": "Aknur Rahman", "given": "Md", "initials": "M"}, {"family": "Ferdousy", "given": "Sonia", "initials": "S"}, {"family": "Akter", "given": "Tahmina", "initials": "T"}, {"family": "Aktar", "given": "Fahima", "initials": "F"}, {"family": "Kuddus", "given": "Md Ruhul", "initials": "MR", "orcid": "0000-0002-7038-3399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6d42cef0bfa4239be0b59e947691ad2.json"}}, {"family": "Rahman", "given": "Md Mustafizur", "initials": "MM", "orcid": "0000-0001-8585-263X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/854727a42e374690931b6200ef95ac32.json"}}, {"family": "Sarker", "given": "Md Moklesur Rahman", "initials": "MMR", "orcid": "0000-0001-9795-0608", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86b27674f7f34e5993d6d26b752860c2.json"}}, {"family": "B\u00fcy\u00fcker", "given": "Sultan Mehtap", "initials": "SM"}, {"family": "Chowdhury", "given": "Jakir Ahmed", "initials": "JA"}, {"family": "Chowdhury", "given": "Abu Asad", "initials": "AA"}, {"family": "Kabir", "given": "Shaila", "initials": "S"}, {"family": "Hossain", "given": "Md Akter", "initials": "MA"}, {"family": "Amran", "given": "Md Shah", "initials": "MS"}], "type": "journal-article", "published": "2021-09-28", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "9", "issue": "10", "pages": "1090", "issn-l": null}, "abstract": null, "doi": "10.3390/vaccines9101090", "pmid": null, "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:29:44.988Z", "modified": "2021-10-26T18:29:45.283Z"}, {"entity": "publication", "iuid": "752e3e4deaa8429fa08ad1282d83045c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/752e3e4deaa8429fa08ad1282d83045c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/752e3e4deaa8429fa08ad1282d83045c"}}, "title": "The untold story of the COVID-19 pandemic: perceptions and views towards social stigma and bullying in the shadow of COVID-19 illness in Jordan.", "authors": [{"family": "Akour", "given": "Amal", "initials": "A", "orcid": "0000-0002-2789-8514", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7afcf3838a0e4150af12424aabdc69ed.json"}}, {"family": "AlMuhaissen", "given": "Suha A", "initials": "SA"}, {"family": "Nusair", "given": "Mohammad B", "initials": "MB"}, {"family": "Al-Tammemi", "given": "Ala'a B", "initials": "AB"}, {"family": "Mahmoud", "given": "Nouf N", "initials": "NN"}, {"family": "Jalouqa", "given": "Sarah", "initials": "S"}, {"family": "Alrawashdeh", "given": "Maissa N", "initials": "MN"}], "type": "journal article", "published": "2021-09-27", "journal": {"title": "SN Soc Sci", "issn": "2662-9283", "volume": "1", "issue": "9", "pages": "240", "issn-l": null}, "abstract": "Stigmatization towards COVID-19 patients can lead to negative outcomes like social exclusion and bullying, and it may hinder the willingness of people to undergo testing. This study aimed to measure and explore the perception of stigmatization and bullying towards COVID-19 patients in Jordan. This was a web-based cross-sectional survey. Participants were recruited from social media platforms employing a snowball convenience sampling. The perception of bullying, beliefs regarding social consequences of infection, views on measures towards violators of patients' privacy, and how to reduce the stigma were assessed by self-reported measures. 397 participants returned completed questionnaires. The majority of respondents believed that COVID-19 patients in Jordan are getting bullied (n = 255, 64.3%) and over 80% believed that people enjoy sharing identities, or news about COVID-19 patients. Although most respondents had adequate knowledge regarding transmission/prevention of COVID-19, they believed that all or some of the COVID-19 patients practiced something wrong to get infected (n = 358, 90.2%). Moreover, 86.9% of respondents reported that people in Jordan were crossing their lines with bullying behaviors towards COVID-19 patients. However, these negative views would not discourage most respondents to get tested and follow the government's instructions if they or any of their acquaintances were suspected to be infected. Our study sheds the light on a high degree of stigma and bullying of COVID-19 patients during the early stage of the pandemic in Jordan. Hence, there is a need to develop and implement effective anti-stigma/anti-bullying campaigns that refute the misperception, raise public knowledge about COVID-19, and spread encouraging messages.", "doi": "10.1007/s43545-021-00252-0", "pmid": "34693341", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "252"}, {"db": "pmc", "key": "PMC8475478"}], "notes": [], "created": "2021-10-26T18:24:07.111Z", "modified": "2021-10-26T18:24:19.356Z"}, {"entity": "publication", "iuid": "7dadb54b658943c599dfcd20763423e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7dadb54b658943c599dfcd20763423e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7dadb54b658943c599dfcd20763423e7"}}, "title": "Effects of the COVID-19 Health Crisis on Sports Practice, Life Quality, and Emotional Status in Spanish High-Performance Athletes.", "authors": [{"family": "Conde", "given": "Elena", "initials": "E"}, {"family": "Mart\u00ednez-Aranda", "given": "Luis Manuel", "initials": "LM"}, {"family": "Sanz", "given": "Gema", "initials": "G"}, {"family": "L\u00f3pez de Subijana", "given": "Cristina", "initials": "C"}, {"family": "S\u00e1nchez-Pato", "given": "Antonio", "initials": "A"}, {"family": "D\u00edaz-Aroca", "given": "\u00c1lvaro", "initials": "\u00c1"}, {"family": "Leiva-Arcas", "given": "Alejandro", "initials": "A"}, {"family": "Garc\u00eda-Roca", "given": "Juan Alfonso", "initials": "JA"}, {"family": "Ramis", "given": "Yago", "initials": "Y"}, {"family": "Torregrossa", "given": "Miquel", "initials": "M"}], "type": "journal article", "published": "2021-09-27", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "12", "issue": null, "pages": "736499"}, "abstract": "Spain is one of the many countries highly affected by the COVID-19 crisis, establishing very restrictive measures with a complete lockdown for more than 3 months. This situation forced the complete closure of sport practice and national or international competitions, leading to a negative impact on physical and psychological health of high-performance athletes. Therefore, the objectives of this study were (a) to determine the effects of the COVID-19 health crisis on Spanish high-performance athletes in terms of sports practice, life quality, and emotional state and (b) to identify the profile with the greatest difficulties during and after the lockdown. A sample of 130 high-performance athletes aged between 18 and 34 years (67 women and 63 men) participated in this study (83.1% achieved a medal in National-International elite competitions; 86.9% were considered student-athletes). Measures included socio-demographic data through a 5-dimension ad hoc survey: physical activity and exercise using an adapted version from the International Physical Activity Questionnaire (IPAQ); health status and limitations using an adapted version of SF-12 Health Questionnaire; Perceived stress (Short-PSS); and Mood States (29-item POMS). All participants have shown a significant decrease pre-post-lockdown in both health and performance perception, especially in women, individual athletes, medalists, and student-athletes. Strong limitations of training, attention, and motivation as well as a moderate negative emotional state during lockdown were reported, in women, individual athletes, medalists, and student-athletes. Even with an improved emotional state and energy level in the post-lockdown period, moderate-to-high stress scores were reported by women and medalists. Our findings highlight the importance of paying attention to the physical and psychological health of elite athletes on three profiles: team athletes (due to social distance), student-athletes (dual-career issues), and women athletes (prevalence of implicit gender inequalities in sport).", "doi": "10.3389/fpsyg.2021.736499", "pmid": "34646217", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8503513"}], "notes": [], "created": "2021-10-21T05:06:54.003Z", "modified": "2022-02-17T09:41:26.123Z"}, {"entity": "publication", "iuid": "d097b7933e1548aa946c8a6664f08eef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d097b7933e1548aa946c8a6664f08eef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d097b7933e1548aa946c8a6664f08eef"}}, "title": "Current international trends in the treatment of multiple sclerosis in children-Impact of the COVID-19 pandemic.", "authors": [{"family": "Sandesj\u00f6", "given": "Fredrik", "initials": "F"}, {"family": "Wassmer", "given": "Evangeline", "initials": "E"}, {"family": "Deiva", "given": "Kumaran", "initials": "K"}, {"family": "Amato", "given": "Maria Pia", "initials": "MP"}, {"family": "Chitnis", "given": "Tanuja", "initials": "T"}, {"family": "Hemingway", "given": "Cheryl", "initials": "C"}, {"family": "Krupp", "given": "Lauren", "initials": "L"}, {"family": "Pohl", "given": "Daniela", "initials": "D"}, {"family": "Rostasy", "given": "Kevin", "initials": "K"}, {"family": "Waubant", "given": "Emanuelle", "initials": "E"}, {"family": "Banwell", "given": "Brenda", "initials": "B"}, {"family": "Wickstr\u00f6m", "given": "Ronny", "initials": "R"}], "type": "journal article", "published": "2021-09-27", "journal": {"title": "Mult Scler Relat Disord", "issn": "2211-0356", "volume": "56", "pages": "103277", "issn-l": null}, "abstract": "Only recently has the first disease-modifying therapy been approved for children with multiple sclerosis (MS) and practice patterns including substantial off-label use have evolved. Understanding attitudes towards treatment of paediatric MS and whether this has changed due to the ongoing COVID-19 pandemic is vital to guide future therapeutic trials and for developing guidelines that reflect practice.\n\nWe performed an online survey within the International Paediatric Multiple Sclerosis Study Group between July and September 2020. The survey was sent to 130 members from 25 countries and consisted of five sections: demographic data, treatment, disease modifying therapies and COVID-19, outcome and three patient cases.\n\nThe survey was completed by 66 members (51%), both paediatric neurologists and adult neurologists. Fingolimod and \u03b2-interferons were the most frequently used disease-modifying therapies, especially among paediatric neurologists. Almost a third (31%) of respondents had altered their prescribing practice due to COVID-19, in particular at the beginning of the pandemic.\n\nThe survey results indicate a tendency of moving from the traditional escalation therapy starting with injectables towards an early start with newer, highly effective disease modifying therapies. The COVID-19 pandemic only slightly affected prescribing patterns and treatment choices in paediatric MS.", "doi": "10.1016/j.msard.2021.103277", "pmid": "34624643", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2211-0348(21)00544-7"}], "notes": [], "created": "2021-10-10T15:03:50.886Z", "modified": "2021-10-10T15:03:50.911Z"}, {"entity": "publication", "iuid": "65abebe3c4d04d1f875bdfda78b65758", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65abebe3c4d04d1f875bdfda78b65758.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65abebe3c4d04d1f875bdfda78b65758"}}, "title": "Increased Risks of Death and Hospitalization in Influenza/Pneumonia and Sepsis for Individuals Affected by Psychotic Disorders, Bipolar Disorders, and Single Manic Episodes: A Retrospective Cross-Sectional Study.", "authors": [{"family": "Nilsson", "given": "Niklas Harry", "initials": "NH"}, {"family": "Bendix", "given": "Marie", "initials": "M"}, {"family": "\u00d6hlund", "given": "Louise", "initials": "L"}, {"family": "Widerstr\u00f6m", "given": "Micael", "initials": "M", "orcid": "0000-0002-1483-4255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ad36fa63a334e3b91499527bb6d5659.json"}}, {"family": "Werneke", "given": "Ursula", "initials": "U", "orcid": "0000-0002-5023-3254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eed3b002ddb4cbba141cbfdc8d3f032.json"}}, {"family": "Maripuu", "given": "Martin", "initials": "M", "orcid": "0000-0001-7868-8894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f85873e152d421eba74e23054d0ff1e.json"}}], "type": "journal article", "published": "2021-09-26", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "10", "issue": "19", "pages": null}, "abstract": "Individuals with severe mental disorders (SMDs) such as psychotic disorders, bipolar disorders, and single manic episodes have increased mortality associated with COVID-19 infection. We set up a population-based study to examine whether individuals with SMD also had a higher risk of hospitalization and death from other infectious conditions. Anonymized and summarized data from multiple Swedish patient registers covering the entire Swedish population were supplied by the Swedish National Board of Health and Welfare. The frequencies of hospitalizations and deaths associated with influenza/pneumonia and sepsis in individuals with SMD were compared with the rest of the population during 2018-2019. Possible contributing comorbidities were also examined, of which diabetes, cardiovascular disease, chronic lung disease, and hypertension were chosen. A total of 7,780,727 individuals were included in the study; 97,034 (1.2%) cases with SMD and 7,683,693 (98.8%) controls. Individuals with SMD had increased risk of death associated with influenza/pneumonia (OR = 2.06, 95% CI [1.87-2.27]) and sepsis (OR = 1.61, 95% CI [1.38-1.89]). They also had an increased risk of hospitalization associated with influenza/pneumonia (OR = 2.12, 95% CI [2.03-2.20]) and sepsis (OR = 1.89, 95% CI [1.75-2.03]). Our results identify a need for further evaluation of whether these individuals should be included in prioritized risk groups for vaccination against infectious diseases other than COVID-19.", "doi": "10.3390/jcm10194411", "pmid": "34640430", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "jcm10194411"}, {"db": "pmc", "key": "PMC8509221"}], "notes": [], "created": "2021-10-21T05:09:08.038Z", "modified": "2022-02-17T09:42:49.284Z"}, {"entity": "publication", "iuid": "2d573fe40a9649649525c7d6641a5a59", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d573fe40a9649649525c7d6641a5a59.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d573fe40a9649649525c7d6641a5a59"}}, "title": "Covid-19 in patients with chronic lymphocytic leukemia: clinical outcome and B- and T-cell immunity during 13 months in consecutive patients.", "authors": [{"family": "Blixt", "given": "Lisa", "initials": "L"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "Johansson", "given": "Hemming", "initials": "H"}, {"family": "Kjellander", "given": "Christian", "initials": "C"}, {"family": "Mravinacova", "given": "Sara", "initials": "S", "orcid": "0000-0003-1848-910X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fc9538cb055479494e5595ed901546a.json"}}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Palma", "given": "Marzia", "initials": "M", "orcid": "0000-0003-4287-3179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a4c445a486340619a33ab910011d64a.json"}}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE", "orcid": "0000-0003-1907-3392", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26a3bf24bd044fbda8ffa0c89974bdfe.json"}}, {"family": "Stromberg", "given": "Olga", "initials": "O"}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M", "orcid": "0000-0002-3793-4064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4bc179656eb442f9ac9dc72c8c6841d.json"}}, {"family": "Zain", "given": "Rula", "initials": "R", "orcid": "0000-0001-8327-846X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5a5815a733a4677b9f38403738a8741.json"}}, {"family": "Hansson", "given": "Lotta", "initials": "L", "orcid": "0000-0001-6614-5737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96cb28e556c643b99c77ce78754738af.json"}}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A", "orcid": "0000-0001-6489-4865", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d91b9eda8764ffea7f7926029c806d2.json"}}], "type": "journal article", "published": "2021-09-25", "journal": {"title": "Leukemia", "issn": "1476-5551", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "We studied clinical and immunological outcome of Covid-19 in consecutive CLL patients from a well-defined area during month 1-13 of the pandemic. Sixty patients (median age 71 y, range 43-97) were identified. Median CIRS was eight (4-20). Patients had indolent CLL (n = 38), had completed (n = 12) or ongoing therapy (n = 10). Forty-six patients (77%) were hospitalized due to severe Covid-19 and 11 were admitted to ICU. Severe Covid-19 was equally distributed across subgroups irrespective of age, gender, BMI, CLL status except CIRS (p < 0.05). Fourteen patients (23%) died; age \u226575 y was the only significant risk factor (p < 0.05, multivariate analysis with limited power). Comparing month 1-6 vs 7-13 of the pandemic, deaths were numerically reduced from 32% to 18%, ICU admission from 37% to 15% whereas hospitalizations remained frequent (86% vs 71%). Seroconversion occurred in 33/40 patients (82%) and anti-SARS-CoV-2 antibodies were detectable at six and 12 months in 17/22 and 8/11 patients, respectively. Most (13/17) had neutralizing antibodies and 19/28 had antibodies in saliva. SARS-CoV-2-specific T-cells (ELISpot) were detected in 14/17 patients. Covid-19 continued to result in high admission even among consecutive and young early- stage CLL patients. A robust and durable B and/or T cell immunity was observed in most convalescents.", "doi": "10.1038/s41375-021-01424-w", "pmid": "34564699", "labels": {"Research Area: High-throughput and high-content serology": null, "Funder: VR": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41375-021-01424-w"}, {"db": "pmc", "key": "PMC8475381"}], "notes": [], "created": "2021-11-18T15:53:16.064Z", "modified": "2021-12-12T18:10:28.317Z"}, {"entity": "publication", "iuid": "8828134f28fd4f4ca34b1436ec27ca9d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8828134f28fd4f4ca34b1436ec27ca9d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8828134f28fd4f4ca34b1436ec27ca9d"}}, "title": "Meaning-Making Coping Methods among Bereaved Parents: A Pilot Survey Study in Sweden.", "authors": [{"family": "Ahmadi", "given": "Fereshteh", "initials": "F", "orcid": "0000-0002-8823-6434", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f4f676633f24637b135c494dcb33cc9.json"}}, {"family": "Zandi", "given": "Saeid", "initials": "S", "orcid": "0000-0003-1272-7170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a941295613dc468e8282c9f8f157a4b6.json"}}], "type": "journal article", "published": "2021-09-24", "journal": {"title": "Behav Sci (Basel)", "issn": "2076-328X", "issn-l": null, "volume": "11", "issue": "10", "pages": null}, "abstract": "The death of a child may result in traumatizing forms of grief, and meaning-making coping with loss seems to be important in prevention of intense psychosocial problems among bereaved parents. The aim of this quantitative pilot study was to discover the divergent meaning-making coping methods used by bereaved parents in Sweden. In doing so, 162 respondents were selected using a convenience sampling method, and they responded to the modified version of RCOPE. The study revealed that the strategies talking to others about their feelings, pondering the meaning of life alone, and being in nature for greater emotional affiliation, i.e., what we call secular existential coping methods, have been the most used meaning-making coping methods among Swedish mourning parents. While explaining the results, we considered the respondents' cultural background and speculated about the potential influence of cultural teachings and elements in the selection of ways of coping with bereavement. Further, we compared the results obtained with those of the two other Swedish studies conducted among people coping with cancer and COVID-19 to further discuss the impact of culture on coping with illness, loss, grief, and crisis. The study supports the idea that culture plays an essential role in the choice of coping methods.", "doi": "10.3390/bs11100131", "pmid": "34677224", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bs11100131"}], "notes": [], "created": "2021-10-26T18:13:36.323Z", "modified": "2022-02-17T09:43:16.000Z"}, {"entity": "publication", "iuid": "b72a917223fa44d19c89cc86317f9892", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b72a917223fa44d19c89cc86317f9892.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b72a917223fa44d19c89cc86317f9892"}}, "title": "Identification of Unique Peptides for SARS-CoV-2 Diagnostics and Vaccine Development by an In Silico Proteomics Approach", "authors": [{"family": "Kesarwani", "given": "Veerbhan", "initials": "V"}, {"family": "Gupta", "given": "Rupal", "initials": "R"}, {"family": "Vetukuri", "given": "Ramesh Raju", "initials": "RR"}, {"family": "Kushwaha", "given": "Sandeep Kumar", "initials": "SK"}, {"family": "Gandhi", "given": "Sonu", "initials": "S"}], "type": "journal-article", "published": "2021-09-24", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "12", "issue": null, "pages": null}, "abstract": null, "doi": "10.3389/fimmu.2021.725240", "pmid": "34630400", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:50:30.496Z", "modified": "2021-11-29T06:11:19.925Z"}, {"entity": "publication", "iuid": "4ec7caedc3b24a29bc302f9d20e3bb70", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ec7caedc3b24a29bc302f9d20e3bb70.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ec7caedc3b24a29bc302f9d20e3bb70"}}, "title": "Power and sample size calculation for the win odds test: application to an ordinal endpoint in COVID-19 trials.", "authors": [{"family": "Gasparyan", "given": "Samvel B", "initials": "SB", "orcid": "0000-0002-4797-2208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fe0aea6b8d940a4aa97beac64753452.json"}}, {"family": "Kowalewski", "given": "Elaine K", "initials": "EK", "orcid": "0000-0002-7915-877X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0c063ae9205470c9803add8044303bc.json"}}, {"family": "Folkvaljon", "given": "Folke", "initials": "F"}, {"family": "Bengtsson", "given": "Olof", "initials": "O"}, {"family": "Buenconsejo", "given": "Joan", "initials": "J", "orcid": "0000-0003-4514-2208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90cef2fa64d0486681f64332929d92cf.json"}}, {"family": "Adler", "given": "John", "initials": "J"}, {"family": "Koch", "given": "Gary G", "initials": "GG"}], "type": "journal article", "published": "2021-09-23", "journal": {"title": "J Biopharm Stat", "issn": "1520-5711", "pages": "1-23", "issn-l": null}, "abstract": "The win odds is a distribution-free method of comparing locations of distributions of two independent random variables. Introduced as a method for analyzing hierarchical composite endpoints, it is well suited to be used in the analysis of ordinal scale endpoints in COVID-19 clinical trials. For a single outcome, we provide power and sample size calculation formulas for the win odds test. We also provide an implementation of the win odds analysis method for a single ordinal outcome in a commonly used statistical software to make the win odds analysis fully reproducible.", "doi": "10.1080/10543406.2021.1968893", "pmid": "34551682", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-27T05:15:02.850Z", "modified": "2021-10-27T05:15:03.000Z"}, {"entity": "publication", "iuid": "7dc1fbdac9ae42de922320b7cfc08524", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7dc1fbdac9ae42de922320b7cfc08524.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7dc1fbdac9ae42de922320b7cfc08524"}}, "title": "Comparing Fear of COVID-19 and Preventive COVID-19 Infection Behaviors Between Iranian and Taiwanese Older People: Early Reaction May Be a Key", "authors": [{"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Liu", "given": "Chieh hsiu", "initials": "Ch"}, {"family": "Hou", "given": "Wen Li", "initials": "WL"}, {"family": "Chen", "given": "Yu Pin", "initials": "YP"}, {"family": "Li", "given": "Yueh Ping", "initials": "YP"}, {"family": "Kuo", "given": "Yi Jie", "initials": "YJ"}, {"family": "Lin", "given": "Chung Ying", "initials": "CY"}, {"family": "Scarf", "given": "Damian", "initials": "D"}], "type": "journal-article", "published": "2021-09-23", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2021.740333", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:49:06.339Z", "modified": "2021-10-11T17:49:06.356Z"}, {"entity": "publication", "iuid": "1b450365873f4738bbced961b479b7cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b450365873f4738bbced961b479b7cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b450365873f4738bbced961b479b7cc"}}, "title": "SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism.", "authors": [{"family": "Jing", "given": "Yukai", "initials": "Y"}, {"family": "Luo", "given": "Li", "initials": "L"}, {"family": "Chen", "given": "Ying", "initials": "Y"}, {"family": "Westerberg", "given": "Lisa S", "initials": "LS"}, {"family": "Zhou", "given": "Peng", "initials": "P", "orcid": "0000-0001-9863-4201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8bf90702b7734b368503bc0926b23738.json"}}, {"family": "Xu", "given": "Zhiping", "initials": "Z"}, {"family": "Herrada", "given": "Andr\u00e9s A", "initials": "AA"}, {"family": "Park", "given": "Chan-Sik", "initials": "CS"}, {"family": "Kubo", "given": "Masato", "initials": "M"}, {"family": "Mei", "given": "Heng", "initials": "H"}, {"family": "Hu", "given": "Yu", "initials": "Y", "orcid": "0000-0002-2815-4568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0af90511a1494949bec5b0e595720c28.json"}}, {"family": "Lee", "given": "Pamela Pui-Wah", "initials": "PP"}, {"family": "Zheng", "given": "Bing", "initials": "B"}, {"family": "Sui", "given": "Zhiwei", "initials": "Z"}, {"family": "Xiao", "given": "Wei", "initials": "W"}, {"family": "Gong", "given": "Quan", "initials": "Q"}, {"family": "Lu", "given": "Zhongxin", "initials": "Z"}, {"family": "Liu", "given": "Chaohong", "initials": "C"}], "type": "journal article", "published": "2021-09-22", "journal": {"title": "Signal Transduct Target Ther", "issn": "2059-3635", "volume": "6", "issue": "1", "pages": "345", "issn-l": null}, "abstract": "The SARS-CoV-2 infection causes severe immune disruption. However, it is unclear if disrupted immune regulation still exists and pertains in recovered COVID-19 patients. In our study, we have characterized the immune phenotype of B cells from 15 recovered COVID-19 patients, and found that healthy controls and recovered patients had similar B-cell populations before and after BCR stimulation, but the frequencies of PBC in patients were significantly increased when compared to healthy controls before stimulation. However, the percentage of unswitched memory B cells was decreased in recovered patients but not changed in healthy controls upon BCR stimulation. Interestingly, we found that CD19 expression was significantly reduced in almost all the B-cell subsets in recovered patients. Moreover, the BCR signaling and early B-cell response were disrupted upon BCR stimulation. Mechanistically, we found that the reduced CD19 expression was caused by the dysregulation of cell metabolism. In conclusion, we found that SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism, which may provide a new intervention target to cure COVID-19.", "doi": "10.1038/s41392-021-00749-3", "pmid": "34552055", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41392-021-00749-3"}, {"db": "pmc", "key": "PMC8456405"}], "notes": [], "created": "2021-10-27T05:16:20.906Z", "modified": "2021-10-27T05:16:21.016Z"}, {"entity": "publication", "iuid": "dce6ed2b4e614c32b631d3857edb6053", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dce6ed2b4e614c32b631d3857edb6053.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dce6ed2b4e614c32b631d3857edb6053"}}, "title": "Making wise choices about low-value health care in the COVID-19 pandemic.", "authors": [{"family": "Clarke", "given": "Mike", "initials": "M"}, {"family": "Born", "given": "Karen", "initials": "K"}, {"family": "Johansson", "given": "Minna", "initials": "M"}, {"family": "J\u00f8rgensen", "given": "Karsten Juhl", "initials": "KJ"}, {"family": "Levinson", "given": "Wendy", "initials": "W"}, {"family": "Madrid", "given": "Eva", "initials": "E"}, {"family": "Meng", "given": "Dina Muscat", "initials": "DM"}, {"family": "Franco", "given": "Juan Victor Ariel", "initials": "JVA"}], "type": "editorial", "published": "2021-09-22", "journal": {"title": "Cochrane Database Syst Rev", "issn": "1469-493X", "volume": "9", "pages": "ED000153", "issn-l": null}, "abstract": null, "doi": "10.1002/14651858.ED000153", "pmid": "34549804", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-10-27T05:13:29.740Z", "modified": "2021-10-27T05:14:17.038Z"}, {"entity": "publication", "iuid": "69390533297940e28f31380bf9b161d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69390533297940e28f31380bf9b161d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69390533297940e28f31380bf9b161d9"}}, "title": "Do conspiracy theory and mistrust undermine people's intention to receive the COVID-19 vaccine in Austria?", "authors": [{"family": "Knobel", "given": "Phil", "initials": "P", "orcid": "0000-0003-2297-1193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bdf58f509c3e4e3b946fdd515d3cc9a8.json"}}, {"family": "Zhao", "given": "Xiang", "initials": "X", "orcid": "0000-0003-1054-9462", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad1f806684e54bc5986a15525c0a7c2d.json"}}, {"family": "White", "given": "Katherine M", "initials": "KM", "orcid": "0000-0002-0345-4724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e0eb1e8900e42c5ab75076f6b169218.json"}}], "type": "journal article", "published": "2021-09-22", "journal": {"title": "J Community Psychol", "issn": "1520-6629", "issn-l": null}, "abstract": "Conspiracy theories flourish during the coronavirus disease 2019 (COVID-19) pandemic especially regarding vaccinations. As the vaccination reluctancy in Austria is high, it is important to understand the antecedents of vaccination intention at the preapproval stage of the vaccination process. An online survey was conducted in August 2020 in Austria with 217 primarily younger, female, educated participants. A two-step cluster analysis resulted in a sceptics cluster with a clear antivaccination tendency along with a right-wing political position, lower trust in general vaccines and lower education levels and the reference cluster. A considerable percentage of participants reported their reluctancy to have a COVID-19 vaccine. Although vaccination intention can be explained by attitude and subjective norm, this decision-making process is undermined by underlying factors such as conspiracy ideation and political position. Policy makers and health interventionists should take political background into consideration in efforts to increase vaccine compliance.", "doi": "10.1002/jcop.22714", "pmid": "34551127", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-27T05:15:41.457Z", "modified": "2021-10-27T05:15:41.597Z"}, {"entity": "publication", "iuid": "b830017933024b4faf78792c42b2bb8a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b830017933024b4faf78792c42b2bb8a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b830017933024b4faf78792c42b2bb8a"}}, "title": "The Impact of COVID-19 on Sleep in Autistic Adults: Longitudinal Comparisons pre and During Lockdown.", "authors": [{"family": "Halstead", "given": "Elizabeth J", "initials": "EJ"}, {"family": "Sullivan", "given": "Emma C", "initials": "EC"}, {"family": "Dimitriou", "given": "Dagmara", "initials": "D"}], "type": "journal article", "published": "2021-09-21", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "708339", "issn-l": "1664-0640"}, "abstract": "Background: The longer-term impact of the pandemic on autistic adults' sleep are yet to be revealed, with studies concentrating on sleep in autistic children or mental health outcomes and coping strategies of autistic adults. Given the prevalence of sleep problems experienced by autistic adults and the changes in routine that have occurred as a result of COVID-19 societal restrictions, this study assessed the impact of the COVID-19 pandemic on sleep problems via a longitudinal subjective assessment method. Methods: Sleep data were gathered at three time points from 95 autistic adults, namely prior to the pandemic, at the start of COVID-19 and several months into COVID-19 to obtain a rich longitudinal dataset ascertaining how/if sleep patterns have changed in autistic adults over these several months. Results: In comparison to pre-lockdown, several sleep components were shown to improve during the lockdown. These improvements included reduced sleep latency (time taken to fall asleep), longer sleep duration, improved sleep efficiency, improved sleep quality, as well as improved daytime functioning. Pre-sleep cognitive arousal scores were found to decrease compared to pre-lockdown, meaning cognitive arousal improved. Approximately 65% of participants reported that they felt their sleep had been impacted since COVID-19 since Time 1, with the most common reasons reported as waking up exhausted (36.92%), not being able to get to sleep (33.85%), waking up in the night (29.23%), having a disrupted sleep pattern (27.69%), and nightmares (18.46%). Conclusions: Improvements in sleep may be related to societal changes (e.g., working from home) during the pandemic. Some of these changes are arguably beneficial for autistic adults in creating a more autism-inclusive society, for example telehealth opportunities for care. Further exploration of the associations between mental health and sleep are warranted.", "doi": "10.3389/fpsyt.2021.708339", "pmid": "34621194", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8490657"}], "notes": [], "created": "2021-10-10T15:08:30.601Z", "modified": "2021-10-10T15:08:30.611Z"}, {"entity": "publication", "iuid": "ef4b77c12ed44ed1a35fa7936352285c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef4b77c12ed44ed1a35fa7936352285c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef4b77c12ed44ed1a35fa7936352285c"}}, "title": "Priority Setting and Equity in COVID-19 Pandemic Plans: A Comparative Analysis of eighteen African Countries.", "authors": [{"family": "Kapiriri", "given": "Lydia", "initials": "L", "orcid": "0000-0002-1237-6369", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec392c3ae33d40f096e713eaa6a2be11.json"}}, {"family": "Kiwanuka", "given": "Suzanne", "initials": "S"}, {"family": "Biemba", "given": "Godfrey", "initials": "G"}, {"family": "Velez", "given": "Claudia", "initials": "C"}, {"family": "Razavi", "given": "S Donya", "initials": "SD"}, {"family": "Abelson", "given": "Julia", "initials": "J"}, {"family": "Essue", "given": "Beverly", "initials": "B"}, {"family": "Danis", "given": "Marion", "initials": "M"}, {"family": "Goold", "given": "Susan", "initials": "S"}, {"family": "Noorulhuda", "given": "Mariam", "initials": "M"}, {"family": "Nouvet", "given": "Elysee", "initials": "E"}, {"family": "Sandman", "given": "Lars", "initials": "L"}, {"family": "Williams", "given": "Ieystn", "initials": "I"}], "type": "journal article", "published": "2021-09-21", "journal": {"title": "Health Policy Plan", "issn": "1460-2237", "issn-l": null}, "abstract": "Priority setting represents an even bigger challenge during public health emergencies than routine times. This is because such emergencies compete with routine programs for the available health resources, strain health systems, and shift health care attention and resources towards containing the spread of the epidemic and treating those that fall seriously ill. This paper is part of a larger global study the aim of which is to evaluate the degree to which National COVID-19 preparedness and response plans incorporated priority setting concepts. IT and provides important insights into what and how priority decisions were made in a context of a pandemic. Specifically, with a focus on a sample of 18 African countries' pandemic plans, the paper aims to: (i) Explore the degree to which the documented priority setting processes adhere to established quality indicators of effective priority setting and (ii) To examine if there is a relationship between the number of quality indicators present in the pandemic plans and the country's economic context, health system and prior experiences with disease outbreaks. All the reviewed plans contained some aspects of expected priority setting processes but none of the national plans addressed all quality parameters. Most of the parameters were mentioned by less than 10 of the 18 country plans reviewed, and several plans identified one or two aspects of fair priority setting processes. Very few plans identified equity as a criterion for priority setting. Since the parameters are relevant to the quality of priority setting that is implemented during public health emergencies, and that most of the countries have pre-existing pandemic plans; it would be advisable that for the future (if not already happening) countries consider priority setting as a critical part of their routine health emergency and disease outbreak plans. Such an approach would ensure that priority setting is integral to pandemic planning, response, and recovery.", "doi": "10.1093/heapol/czab113", "pmid": "34545395", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6373138"}, {"db": "pmc", "key": "PMC8500007"}], "notes": [], "created": "2021-10-27T05:11:43.795Z", "modified": "2021-10-27T05:11:43.870Z"}, {"entity": "publication", "iuid": "610e095b5ab7410aaf936ca232bbc206", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/610e095b5ab7410aaf936ca232bbc206.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/610e095b5ab7410aaf936ca232bbc206"}}, "title": "Match-Fixing Causing Harm to Athletes on a COVID-19-Influenced Gambling Market: A Call for Research During the Pandemic and Beyond.", "authors": [{"family": "H\u00e5kansson", "given": "A", "initials": "A"}, {"family": "J\u00f6nsson", "given": "C", "initials": "C"}, {"family": "Kentt\u00e4", "given": "G", "initials": "G"}], "type": "journal article", "published": "2021-09-21", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "712300", "issn-l": "1664-1078"}, "abstract": "Match-fixing, although not a new problem, has received growing attention during the COVID-19 pandemic, which has been reported in the media to have increased the risk of match-fixing events. Gambling is a well-documented addictive behavior, and gambling-related fraud, match-fixing, is a challenge to the world of sports. Most research on match-fixing has a judicial or institutional perspective, and few studies focus on its individual consequences. Nevertheless, athletes may be at particular risk of mental health consequences from the exposure to or involvement in match-fixing. The COVID-19 crisis puts a spotlight on match-fixing, as the world of competitive sports shut down or changed substantially due to pandemic-related restrictions. We call for research addressing individual mental health and psycho-social correlates of match-fixing, and their integration into research addressing problem gambling, related to the pandemic and beyond.", "doi": "10.3389/fpsyg.2021.712300", "pmid": "34621216", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8490709"}], "notes": [], "created": "2021-10-10T15:08:15.461Z", "modified": "2021-10-10T15:08:15.471Z"}, {"entity": "publication", "iuid": "dfbabb7d946f4e988f6f3f48695c7edb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dfbabb7d946f4e988f6f3f48695c7edb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dfbabb7d946f4e988f6f3f48695c7edb"}}, "title": "Using informative features in machine learning based method for COVID-19 drug repurposing.", "authors": [{"family": "Aghdam", "given": "Rosa", "initials": "R", "orcid": "0000-0001-9045-9592", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/947e042b69f44191bb9aa48ca17314bb.json"}}, {"family": "Habibi", "given": "Mahnaz", "initials": "M"}, {"family": "Taheri", "given": "Golnaz", "initials": "G"}], "type": "journal article", "published": "2021-09-20", "journal": {"title": "J Cheminform", "issn": "1758-2946", "volume": "13", "issue": "1", "pages": "70", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) is caused by a novel virus named Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). This virus induced a large number of deaths and millions of confirmed cases worldwide, creating a serious danger to public health. However, there are no specific therapies or drugs available for COVID-19 treatment. While new drug discovery is a long process, repurposing available drugs for COVID-19 can help recognize treatments with known clinical profiles. Computational drug repurposing methods can reduce the cost, time, and risk of drug toxicity. In this work, we build a graph as a COVID-19 related biological network. This network is related to virus targets or their associated biological processes. We select essential proteins in the constructed biological network that lead to a major disruption in the network. Our method from these essential proteins chooses 93 proteins related to COVID-19 pathology. Then, we propose multiple informative features based on drug-target and protein-protein interaction information. Through these informative features, we find five appropriate clusters of drugs that contain some candidates as potential COVID-19 treatments. To evaluate our results, we provide statistical and clinical evidence for our candidate drugs. From our proposed candidate drugs, 80% of them were studied in other studies and clinical trials.", "doi": "10.1186/s13321-021-00553-9", "pmid": "34544500", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13321-021-00553-9"}, {"db": "pmc", "key": "PMC8451172"}], "notes": [], "created": "2021-10-10T15:37:29.486Z", "modified": "2021-11-19T10:49:54.346Z"}, {"entity": "publication", "iuid": "a245e60b78414c3b85feb1892b29e055", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a245e60b78414c3b85feb1892b29e055.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a245e60b78414c3b85feb1892b29e055"}}, "title": "The Association Between Financial Hardship and Mental Health Difficulties Among Adult Wage Earners During the COVID-19 Pandemic in Bangladesh: Findings From a Cross-Sectional Analysis.", "authors": [{"family": "Sultana", "given": "Mst Sadia", "initials": "MS"}, {"family": "Khan", "given": "Abid Hasan", "initials": "AH"}, {"family": "Hossain", "given": "Sahadat", "initials": "S"}, {"family": "Islam", "given": "Tauhidul", "initials": "T"}, {"family": "Hasan", "given": "M Tasdik", "initials": "MT"}, {"family": "Ahmed", "given": "Helal Uddin", "initials": "HU"}, {"family": "Li", "given": "Zezhi", "initials": "Z"}, {"family": "Khan", "given": "Jahangir A M", "initials": "JAM"}], "type": "journal article", "published": "2021-09-20", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "635884", "issn-l": "1664-0640"}, "abstract": "Background: The ongoing COVID-19 pandemic has created several challenges including financial burdens that may result in mental health conditions. This study was undertaken to gauge mental health difficulties during the COVID-19 pandemic and gain an insight into wage earners' mental health. Method: This cross-sectional study was conducted through an online survey. A t total of 707 individual Bangladeshi wage earners were enrolled between 20 and 30 May 2020. The questionnaire had sections on sociodemographic information, COVID-19 related questions, PHQ-9 and GAD-7 scales. STATA version 14.1 program was used to carry out all the analyses. Results: The study revealed that 58.6 and 55.9% of the respondents had moderate to severe anxiety and depressive symptoms, respectively. The total monthly income was <30,000 BDT (353.73USD) and displayed increased odds of suffering from depressive symptoms (OR = 4.12; 95% CI: 2.68-6.34) and anxiety (OR = 3.31; 95% CI: 2.17-5.03). Participants who did not receive salary income, had no income source during the pandemic, had financial problems, and inadequate food supply and were more likely to suffer from anxiety and depressive symptoms (p \u2264 0.01). Perceiving the upcoming financial crisis as a stressor was a potential risk factor for anxiety (OR = 1.91; 95% CI:1.32-2.77) and depressive symptoms (OR = 1.50; 95% CI:1.04-2.16). Limitations: The online survey method used in this study limits the generalizability of the findings and self-reported answers might include selection and social desirability bias as a community-based survey was not possible during the pandemic. Conclusion: Wage earners in a low resource setting like Bangladesh require mental health attention and financial consideration to deal with mental health difficulties.", "doi": "10.3389/fpsyt.2021.635884", "pmid": "34616314", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8488168"}], "notes": [], "created": "2021-10-10T15:25:30.166Z", "modified": "2021-10-10T15:25:30.177Z"}, {"entity": "publication", "iuid": "7b93bc8d2d3443a98a676c5352936599", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b93bc8d2d3443a98a676c5352936599.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b93bc8d2d3443a98a676c5352936599"}}, "title": "Sickness Presenteeism Among the Swedish Self-Employed During the Covid-19 Pandemic.", "authors": [{"family": "Vinberg", "given": "Stig", "initials": "S"}, {"family": "Landstad", "given": "Bodil J", "initials": "BJ"}, {"family": "Tjulin", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Nordenmark", "given": "Mikael", "initials": "M"}], "type": "journal article", "published": "2021-09-20", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "723036", "issn-l": "1664-1078"}, "abstract": "The present study analyzed the impact of business operations, work and family circumstances, and well-being on the risk of sickness presenteeism for Swedish self-employed workers during the Covid-19 pandemic. It is of great importance to investigate the impact of the pandemic on the self-employed and their enterprises because they are seen as key drivers of economic growth and constitute an expanding group in many countries. Data were obtained from 845 self-employed workers by a web-based survey including questions about background information, work and family circumstances, well-being, sickness presenteeism, and questions about the pandemic. Results were that around 40% of the self-employed introduced new products, processes, and marketing methods, and just over 50% attempted to get new customers during the pandemic. Nearly half of the self-employed people reported that they lost contracts, and 22% judged the risk of bankruptcy to be quite or highly likely. Regression analyses showed that the more the self-employed reported impact on business indicators, increased work hours, a higher level of work-family conflict, and a lower level of mental well-being, the higher the risk of sickness presenteeism. The most common reasons given by the participants for sickness presenteeism during the pandemic were \"nobody else can carry out my responsibilities,\" \"I can't afford to take sick leave\" and \"I enjoy my work.\" Conclusions are that a critical event such as the pandemic probably adds to an already high workload for the self-employed. Impact on business operations such as developing new products/services and marketing, risk of bankruptcy and increased work hours seems to be important factors for explaining sickness presenteeism among the self-employed. Theoretical contributions from the study suggest that critical events such as the Covid-19 pandemic should be considered as an important environmental factor when studying sickness presenteeism among self-employed.", "doi": "10.3389/fpsyg.2021.723036", "pmid": "34621220", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8490737"}], "notes": [], "created": "2021-10-10T15:07:50.898Z", "modified": "2021-10-10T15:07:50.911Z"}, {"entity": "publication", "iuid": "1c094d4be4214666a0f2dbbfc37eb5cd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1c094d4be4214666a0f2dbbfc37eb5cd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1c094d4be4214666a0f2dbbfc37eb5cd"}}, "title": "Risk-Assessment of Hospitalized Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infected Patients Using Laboratory Data and Immune Cell Morphological Assessment.", "authors": [{"family": "Kubik", "given": "Thane", "initials": "T"}, {"family": "Hou", "given": "Mary", "initials": "M"}, {"family": "Traverse", "given": "Tammie", "initials": "T"}, {"family": "Lareau", "given": "Mireille", "initials": "M"}, {"family": "Jenei", "given": "Veronika", "initials": "V"}, {"family": "Oberding", "given": "Lisa", "initials": "L"}, {"family": "Pillai", "given": "Dylan R", "initials": "DR"}, {"family": "Gillrie", "given": "Mark", "initials": "M"}, {"family": "Suryanarayan", "given": "Deepa", "initials": "D"}, {"family": "Sidhu", "given": "Davinder Singh", "initials": "DS"}, {"family": "Vergara-Lluri", "given": "Maria", "initials": "M"}, {"family": "Nakashima", "given": "Megan O", "initials": "MO"}, {"family": "Mahe", "given": "Etienne", "initials": "E"}], "type": "journal article", "published": "2021-09-20", "journal": {"title": "Arch Pathol Lab Med", "issn": "1543-2165", "issn-l": null}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious agent, with the propensity to cause severe illness. While vaccine uptake has been increasing in recent months, many regions remain at risk of significant coronavirus disease 19 (COVID-19) related healthcare burden. Health systems will continue to benefit from the availability of a variety of clinical and laboratory model when other triaging models are equivocal.\n\nTo validate previously reported clinical laboratory abnormalities seen in COVID-19 patients and identify what laboratory parameters might be outcome-predictive.\n\nWe undertook an observational study of hospital-admitted COVID-19 patients (n=113), looking at a broad selection of clinical, laboratory, peripheral blood smear, and outcome data over discrete discovery and validation periods from March 2020 to November 2020.\n\nWe confirmed the findings of previous studies noting derangement of a variety of laboratory parameters in COVID-19 patients, including peripheral blood morphological changes. We also devised a simple-to-use decision tree by which patients could be risk stratified on the basis of Red Blood Cell count, creatinine, urea, and atypical plasmacytoid lymphocyte (\"covidocyte\") count. This outcome classifier performed comparably to the World Health Organization clinical classifier and the neutrophil-lymphocyte ratio.\n\nOur data add to the increasing number of studies cataloguing laboratory changes in COVID-19, and support the clinical utility of incorporating blood morphological assessment in the workup of hospitalized COVID-19 patients.", "doi": "10.5858/arpa.2021-0368-SA", "pmid": "34543379", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "470568"}], "notes": [], "created": "2021-10-10T15:35:57.917Z", "modified": "2021-10-10T15:35:57.929Z"}, {"entity": "publication", "iuid": "a95016e0838f4ca0ba303faaf486166e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a95016e0838f4ca0ba303faaf486166e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a95016e0838f4ca0ba303faaf486166e"}}, "title": "Factors affecting Pakistani young adults' intentions to uptake COVID-19 vaccination: An extension of the theory of planned behavior.", "authors": [{"family": "Ullah", "given": "Irfan", "initials": "I", "orcid": "0000-0003-1100-101X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8d5a7e15ae6487cbdda0de3b2a531c3.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Malik", "given": "Najma Iqbal", "initials": "NI", "orcid": "0000-0002-3521-1014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c17242b513143b18e3bb8108f009ca4.json"}}, {"family": "Wu", "given": "Tzu-Yi", "initials": "TY"}, {"family": "Araban", "given": "Marzieh", "initials": "M", "orcid": "0000-0001-9920-0261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/267b131c24034c33b0ddff1b97f316a5.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-09-20", "journal": {"title": "Brain Behav", "issn": "2162-3279", "pages": "e2370", "issn-l": null}, "abstract": "Aside from personal beliefs, young adults' intention to uptake the COVID-19 vaccine can be influenced by their fear of COVID-19 and perceived infectability of COVID-19. The present study incorporated fear of COVID-19 and perceived infectability with the theory of planned behavior (TPB) to form an expanded TPB to analyze factors affecting Pakistani young adults' intentions to uptake the COVID-vaccine in Pakistan.\n\nA cross-sectional study was conducted and recruited participants from Pakistani social media users. The proposed extended TPB model was examined by using structural equation modeling.\n\nA total of 1034 individuals replied to the survey. The three factors of the original theory of planned behavior and the fear of COVID-19 were positively related to their intention to uptake COVID-19 vaccination (r = 0.25-0.66). Moreover, the perceived infectability positively influenced the three theories of planned behavioral factors and the fear of COVID-19 (r = 0.27-0.60), also affecting the participants' intentions to uptake COVID-19 vaccination.\n\nPerceived infectability was positively related to the participants' intentions to uptake COVID-19 vaccination, and perceived behavioral control was the strongest mediator. More evidence-based information concerning treatments and COVID-19 vaccination are needed to encourage individuals to uptake the vaccine.", "doi": "10.1002/brb3.2370", "pmid": "34543522", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:36:16.800Z", "modified": "2021-11-18T14:28:01.679Z"}, {"entity": "publication", "iuid": "26f7a8f9b07448189123efea423b99df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26f7a8f9b07448189123efea423b99df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26f7a8f9b07448189123efea423b99df"}}, "title": "Civil-Military Collaboration to Facilitate Rapid Deployment of a Mobile Laboratory in Early Response to COVID-19: A High-Readiness Exercise.", "authors": [{"family": "Bacchus", "given": "Philip", "initials": "P"}, {"family": "Nissen", "given": "Karolina", "initials": "K"}, {"family": "Berg", "given": "Johanna", "initials": "J"}, {"family": "Br\u00e5ve", "given": "Andreas", "initials": "A"}, {"family": "Gyll", "given": "Jenny", "initials": "J"}, {"family": "Larsson", "given": "Christer", "initials": "C"}, {"family": "Muradrasoli", "given": "Shaman", "initials": "S"}, {"family": "Tellstr\u00f6m", "given": "Andreas", "initials": "A"}, {"family": "Salaneck", "given": "Erik", "initials": "E"}], "type": "journal article", "published": "2021-09-20", "journal": {"title": "Health Secur", "issn": "2326-5108", "volume": "19", "issue": "5", "pages": "488-497", "issn-l": null}, "abstract": "Rapid and adaptable diagnostic capabilities are of great importance in the face of emerging infectious diseases. In an outbreak, timely establishment of diagnostic routines is crucial to identifying cases and preventing the spread of the disease, especially when faced with high-consequence pathogens. In this article, we describe a multiagency exercise including the rapid deployment and diagnostic adaptation of the Swedish Armed Forces mobile laboratory (biological field analysis laboratory) in the context of COVID-19. This deployment was initiated as a high-readiness exercise at the end of January 2020, when the global development of the outbreak was still uncertain. Through collaboration with the Public Health Agency of Sweden and a civilian hospital, a real-time reverse transcriptase polymerase chain reaction method specific to SARS-CoV-2 was made available and adapted to the mobile laboratory, and the team established and evaluated a functional and efficient diagnostic asset along with a logistical support chain. We also organized and evaluated mobile testing teams, and the method was later used in large-scale, national, cross-sectional COVID-19 surveys in several regions of Sweden. In this article, we focus on the challenges of overbridging the civil-military interface in this context and identifying lessons learned and added values to the response during the early pandemic. We propose that the experiences from this exercise and governmental agency collaboration are valuable in preparation for future outbreaks.", "doi": "10.1089/hs.2021.0011", "pmid": "34542343", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:35:34.328Z", "modified": "2021-11-18T14:21:28.133Z"}, {"entity": "publication", "iuid": "5d7ab7aa2e3f45998eec2af19db5271f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d7ab7aa2e3f45998eec2af19db5271f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d7ab7aa2e3f45998eec2af19db5271f"}}, "title": "Declining mortality of cerebral venous sinus thrombosis with thrombocytopenia after SARS-CoV-2 vaccination.", "authors": [{"family": "van de Munckhof", "given": "Anita", "initials": "A"}, {"family": "Krzywicka", "given": "Katarzyna", "initials": "K"}, {"family": "Aguiar de Sousa", "given": "Diana", "initials": "D", "orcid": "0000-0002-6702-7924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cc3515119a247859fe1fea025f703ef.json"}}, {"family": "S\u00e1nchez van Kammen", "given": "Mayte", "initials": "M"}, {"family": "Heldner", "given": "Mirjam R", "initials": "MR", "orcid": "0000-0002-3594-2159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8280f8c6ea3a486abae8acc6aa491985.json"}}, {"family": "Jood", "given": "Katarina", "initials": "K"}, {"family": "Lindgren", "given": "Erik", "initials": "E", "orcid": "0000-0002-7628-5044", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e973b3c74ff4e5cba42da605a13bc61.json"}}, {"family": "Tatlisumak", "given": "Turgut", "initials": "T"}, {"family": "Putaala", "given": "Jukka", "initials": "J"}, {"family": "Kremer Hovinga", "given": "Johanna A", "initials": "JA"}, {"family": "Middeldorp", "given": "Saskia", "initials": "S"}, {"family": "Levi", "given": "Marcel", "initials": "M"}, {"family": "Arnold", "given": "Marcel", "initials": "M"}, {"family": "Ferro", "given": "Jos\u00e9 M", "initials": "JM"}, {"family": "Coutinho", "given": "Jonathan M", "initials": "JM", "orcid": "0000-0002-8284-982X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98cadafdcc044688bab25a3d7f9562b9.json"}}], "type": "journal article", "published": "2021-09-18", "journal": {"title": "Eur J Neurol", "issn": "1468-1331", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "High mortality rates have been reported in patients with cerebral venous sinus thrombosis (CVST) due to vaccine-induced immune thrombotic thrombocytopenia (VITT) after vaccination with adenoviral vector SARS-CoV-2 vaccines. The aim of this study was to evaluate whether mortality of patients with CVST-VITT has decreased over time.\r\n\r\nWe used the EudraVigilance database of the European Medicines Agency to identify cases of CVST with concomitant thrombocytopenia occurring within 28 days of SARS-CoV-2 vaccination. Vaccines were grouped based on vaccine type (adenoviral or mRNA). Cases with CVST onset until 28 March were compared to cases after 28 March 2021, which was the day when the first scientific paper on VITT was published.\r\n\r\nWe identified 270 cases of CVST with thrombocytopenia, of which 266 (99%) occurred after adenoviral vector SARS-CoV-2 vaccination (ChAdOx1 nCoV-19 n=243, Ad26.COV2.S n=23). Reported mortality among adenoviral cases with onset up to 28 March 2021 was 47/99 (47%, 95%CI 37-58%) compared to 36/167 (22%, 95%CI 16-29%) in cases with onset after 28 March (p=<0.001). None of the 4 cases of CVST with thrombocytopenia occurring after mRNA vaccination died.\r\n\r\nReported mortality of CVST with thrombocytopenia after vaccination with adenoviral vector-based SARS-CoV-2 vaccines has significantly decreased over time, which may indicate a beneficial effect of earlier recognition and/or improved treatment on outcome after VITT.", "doi": "10.1111/ene.15113", "pmid": "34536256", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-09-20T16:56:40.912Z", "modified": "2021-12-07T15:26:05.448Z"}, {"entity": "publication", "iuid": "89ad16f8a9aa42e793d7f2ed72e2371c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/89ad16f8a9aa42e793d7f2ed72e2371c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/89ad16f8a9aa42e793d7f2ed72e2371c"}}, "title": "Monthlong Intubated Patient with Life-Threatening COVID-19 and Cerebral Microbleeds Suffers Only Mild Cognitive Sequelae at 8-Month Follow-up: A Case Report.", "authors": [{"family": "Backman", "given": "Linda", "initials": "L"}, {"family": "M\u00f6ller", "given": "Marika C", "initials": "MC"}, {"family": "Thelin", "given": "Eric P", "initials": "EP"}, {"family": "Dahlgren", "given": "Daniel", "initials": "D"}, {"family": "Deboussard", "given": "Catharina", "initials": "C"}, {"family": "\u00d6stlund", "given": "Gunilla", "initials": "G"}, {"family": "Lindau", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-09-17", "journal": {"title": "Arch Clin Neuropsychol", "issn": "1873-5843", "issn-l": null}, "abstract": "To elaborate on possible cognitive sequelae related to COVID-19, associated cerebrovascular injuries as well as the general consequences from intensive care. COVID-19 is known to have several, serious CNS-related consequences, but neuropsychological studies of severe COVID-19 are still rare.\n\nM., a 45-year-old man, who survived a severe COVID-19 disease course including Acute Respiratory Distress Syndrome (ARDS), cerebral microbleeds, and 35 days of mechanical ventilation, is described. We elaborate on M's recovery and rehabilitation process from onset to the 8-month follow-up. The cognitive functions were evaluated with a comprehensive screening battery at 4 weeks after extubation and at the 8-month follow-up.\n\nFollowing extubation, M. was delirious, reported visual hallucinations, and had severe sleeping difficulties. At about 3 months after COVID-19 onset, M. showed mild to moderate deficits on tests measuring processing speed, working memory, and attention. At assessments at 8 months, M. performed better, with results above average on tests measuring learning, memory, word fluency, and visuospatial functions. Minor deficits were still found regarding logical reasoning, attention, executive functioning, and processing speed. There were no lingering psychiatric symptoms. While M. had returned to a part-time job, he was not able to resume previous work-tasks.\n\nThis case-study demonstrates possible cognitive deficits after severe COVID-19 and emphasizes the need of a neuropsychological follow-up, with tests sensitive to minor deficits. The main findings of this report provide some support that the long-term prognosis for cognition in severe COVID-19 may be hopeful.", "doi": "10.1093/arclin/acab075", "pmid": "34530432", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6371352"}], "notes": [], "created": "2021-09-20T16:53:26.335Z", "modified": "2021-09-20T16:53:37.245Z"}, {"entity": "publication", "iuid": "8e5828a256014e558fdb864e18dd43d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e5828a256014e558fdb864e18dd43d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e5828a256014e558fdb864e18dd43d4"}}, "title": "Heart failure in COVID-19: the multicentre, multinational PCHF-COVICAV registry.", "authors": [{"family": "Sokolski", "given": "Mateusz", "initials": "M", "orcid": "0000-0001-9925-3566", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19276192c9dd4c47b35f4877b039b729.json"}}, {"family": "Trenson", "given": "Sander", "initials": "S", "orcid": "0000-0002-3902-0047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de369e2bc9d24a359ff118e2c1c7c79c.json"}}, {"family": "Sokolska", "given": "Justyna M", "initials": "JM", "orcid": "0000-0002-4759-5879", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8169d90790945999f1701f0f1e6ae26.json"}}, {"family": "D'Amario", "given": "Domenico", "initials": "D"}, {"family": "Meyer", "given": "Philippe", "initials": "P"}, {"family": "Poku", "given": "Nana K", "initials": "NK"}, {"family": "Biering-S\u00f8rensen", "given": "Tor", "initials": "T"}, {"family": "H\u00f8jbjerg Lassen", "given": "Mats C", "initials": "MC"}, {"family": "Skaarup", "given": "Kristoffer G", "initials": "KG"}, {"family": "Barge-Caballero", "given": "Eduardo", "initials": "E"}, {"family": "Pouleur", "given": "Anne-Catherine", "initials": "AC"}, {"family": "Stolfo", "given": "Davide", "initials": "D"}, {"family": "Sinagra", "given": "Gianfranco", "initials": "G"}, {"family": "Ablasser", "given": "Klemens", "initials": "K"}, {"family": "Muster", "given": "Viktoria", "initials": "V"}, {"family": "Rainer", "given": "Peter P", "initials": "PP"}, {"family": "Wallner", "given": "Markus", "initials": "M"}, {"family": "Chiodini", "given": "Alessandra", "initials": "A"}, {"family": "Heiniger", "given": "Pascal S", "initials": "PS"}, {"family": "Mikulicic", "given": "Fran", "initials": "F"}, {"family": "Schwaiger", "given": "Judith", "initials": "J"}, {"family": "Winnik", "given": "Stephan", "initials": "S"}, {"family": "Cakmak", "given": "Huseyin A", "initials": "HA"}, {"family": "Gaudenzi", "given": "Margherita", "initials": "M"}, {"family": "Mapelli", "given": "Massimo", "initials": "M"}, {"family": "Mattavelli", "given": "Irene", "initials": "I"}, {"family": "Paul", "given": "Matthias", "initials": "M"}, {"family": "Cabac-Pogorevici", "given": "Irina", "initials": "I"}, {"family": "Bouleti", "given": "Claire", "initials": "C"}, {"family": "Lilliu", "given": "Marzia", "initials": "M"}, {"family": "Minoia", "given": "Chiara", "initials": "C"}, {"family": "Dauw", "given": "Jeroen", "initials": "J"}, {"family": "Costa", "given": "J\u00e9r\u00f4me", "initials": "J"}, {"family": "Celik", "given": "Ahmet", "initials": "A"}, {"family": "Mewton", "given": "Nathan", "initials": "N"}, {"family": "Montenegro", "given": "Carlos E L", "initials": "CEL"}, {"family": "Matsue", "given": "Yuya", "initials": "Y"}, {"family": "Loncar", "given": "Goran", "initials": "G"}, {"family": "Marchel", "given": "Michal", "initials": "M"}, {"family": "Bechlioulis", "given": "Aris", "initials": "A"}, {"family": "Michalis", "given": "Lampros", "initials": "L"}, {"family": "D\u00f6rr", "given": "Marcus", "initials": "M"}, {"family": "Prihadi", "given": "Edgard", "initials": "E"}, {"family": "Schoenrath", "given": "Felix", "initials": "F"}, {"family": "Messroghli", "given": "Daniel R", "initials": "DR"}, {"family": "Mullens", "given": "Wilfried", "initials": "W"}, {"family": "Lund", "given": "Lars H", "initials": "LH"}, {"family": "Rosano", "given": "Giuseppe M C", "initials": "GMC", "orcid": "0000-0002-6868-4248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9db1f3658c8746599ddc172e6604c5b4.json"}}, {"family": "Ponikowski", "given": "Piotr", "initials": "P", "orcid": "0000-0002-3391-7064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9e5fe099039493dbc18fbfd549d4077.json"}}, {"family": "Ruschitzka", "given": "Frank", "initials": "F", "orcid": "0000-0001-5972-0596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/681536426df648299efac9c2e568ad13.json"}}, {"family": "Flammer", "given": "Andreas J", "initials": "AJ", "orcid": "0000-0002-1373-0630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/efbe793c83aa487ba4d0d6b021276670.json"}}], "type": "journal article", "published": "2021-09-17", "journal": {"title": "ESC Heart Fail", "issn": "2055-5822", "issn-l": null}, "abstract": "We assessed the outcome of hospitalized coronavirus disease 2019 (COVID-19) patients with heart failure (HF) compared with patients with other cardiovascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia). We further wanted to determine the incidence of HF events and its consequences in these patient populations.\n\nInternational retrospective Postgraduate Course in Heart Failure registry for patients hospitalized with COVID-19 and CArdioVascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia) was performed in 28 centres from 15 countries (PCHF-COVICAV). The primary endpoint was in-hospital mortality. Of 1974 patients hospitalized with COVID-19, 1282 had cardiovascular disease and/or risk factors (median age: 72 [interquartile range: 62-81] years, 58% male), with HF being present in 256 [20%] patients. Overall in-hospital mortality was 25% (n = 323/1282 deaths). In-hospital mortality was higher in patients with a history of HF (36%, n = 92) compared with non-HF patients (23%, n = 231, odds ratio [OR] 1.93 [95% confidence interval: 1.44-2.59], P < 0.001). After adjusting, HF remained associated with in-hospital mortality (OR 1.45 [95% confidence interval: 1.01-2.06], P = 0.041). Importantly, 186 of 1282 [15%] patients had an acute HF event during hospitalization (76 [40%] with de novo HF), which was associated with higher in-hospital mortality (89 [48%] vs. 220 [23%]) than in patients without HF event (OR 3.10 [2.24-4.29], P < 0.001).\n\nHospitalized COVID-19 patients with HF are at increased risk for in-hospital death. In-hospital worsening of HF or acute HF de novo are common and associated with a further increase in in-hospital mortality.", "doi": "10.1002/ehf2.13549", "pmid": "34533287", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-09-20T16:55:47.088Z", "modified": "2021-09-20T16:56:00.074Z"}, {"entity": "publication", "iuid": "dd02639389794c4c97fa776727dbcdb9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dd02639389794c4c97fa776727dbcdb9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dd02639389794c4c97fa776727dbcdb9"}}, "title": "Neurological manifestations of COVID-19: A comprehensive literature review and discussion of mechanisms.", "authors": [{"family": "Johansson", "given": "Anton", "initials": "A"}, {"family": "Mohamed", "given": "Mohamed S", "initials": "MS"}, {"family": "Moulin", "given": "Thiago C", "initials": "TC"}, {"family": "Schi\u00f6th", "given": "Helgi B", "initials": "HB"}], "type": "journal article", "published": "2021-09-15", "journal": {"title": "J Neuroimmunol", "issn": "1872-8421", "volume": "358", "pages": "577658", "issn-l": null}, "abstract": "Several neurological symptoms and complications have been described in association with COVID-19, such as anosmia, ageusia, encephalitis and Guillain-Barr\u00e9 syndrome. Here, we review the literature describing SARS-CoV-2-induced neurological manifestations and provide a comprehensive discussion of proposed mechanisms underlying the neurological pathophysiology. First, we analyse the neuroinvasiveness potential of the coronavirus family based on previous SARS-CoV-1 studies. Then, we describe the current evidence on COVID-19-induced nervous tissue damage, including processes behind brain vasculopathy and cytokine storm. We also discuss in detail anosmia and Guillain-Barr\u00e9 syndrome. Finally, we provide a summarised timeline of the main findings in the field. Future perspectives are presented, and suggestions of further investigations to clarify how SARS-COV-2 can affect the CNS.", "doi": "10.1016/j.jneuroim.2021.577658", "pmid": "34304141", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8272134"}, {"db": "pii", "key": "S0165-5728(21)00185-5"}], "notes": [], "created": "2021-08-05T07:03:24.380Z", "modified": "2023-01-13T13:24:48.655Z"}, {"entity": "publication", "iuid": "cdb5c73e050b4848a26ea799d4720749", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cdb5c73e050b4848a26ea799d4720749.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cdb5c73e050b4848a26ea799d4720749"}}, "title": "Internet addiction and psychological distress among Chinese schoolchildren before and during the COVID-19 outbreak: A latent class analysis.", "authors": [{"family": "Chen", "given": "I-Hua", "initials": "I"}, {"family": "Chen", "given": "Chao-Ying", "initials": "C"}, {"family": "Liu", "given": "Chieh-Hsiu", "initials": "C"}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Chen", "given": "Yu-Pin", "initials": "Y"}, {"family": "Kuo", "given": "Yi-Jie", "initials": "Y"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Wang", "given": "Shu-Mei", "initials": "S"}], "type": "journal article", "published": "2021-09-15", "journal": {"title": "J Behav Addict", "issn": "2063-5303", "issn-l": null, "volume": "10", "issue": "3", "pages": "731-746"}, "abstract": "The present longitudinal study examined the changes in problematic internet use (problematic smartphone use, problematic social media use, and problematic gaming) and changes in COVID-19-related psychological distress (fear of COVID-19 and worry concerning COVID-19) across three time-points (before the COVID-19 outbreak, during the initial stages of the COVID-19 outbreak, and during the COVID-19 outbreak recovery period).\r\n\r\nA total of 504 Chinese schoolchildren completed measures concerning problematic internet use and psychological distress across three time-points. Latent class analysis (LCA) was used to classify participants into three groups of problematic internet use comprising Group 1 (lowest level), Group 2 (moderate level), and Group 3 (highest level).\r\n\r\nStatistical analyses showed that as problematic use of internet-related activities declined among Group 3 participants across the three time points, participants in Group 1 and Group 2 had increased problematic use of internet-related activities. Although there was no between-group difference in relation to worrying concerning COVID-19 infection, Groups 2 and 3 had significantly higher levels of fear of COVID-19 than Group 1 during the COVID-19 recovery period. Regression analysis showed that change in problematic internet use predicted fear of COVID-19 during the recovery period.\r\n\r\nThe varied levels of problematic internet use among schoolchildren reflect different changing trends of additive behaviors during COVID-19 outbreak and recovery periods.", "doi": "10.1556/2006.2021.00052", "pmid": "34529588", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-09-20T16:52:00.538Z", "modified": "2021-11-18T14:20:35.797Z"}, {"entity": "publication", "iuid": "a404c0efa6384c3b9e7bcc42befc5f5a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a404c0efa6384c3b9e7bcc42befc5f5a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a404c0efa6384c3b9e7bcc42befc5f5a"}}, "title": "A Public Health Research Agenda for Managing Infodemics: Methods and Results of the First WHO Infodemiology Conference.", "authors": [{"family": "Calleja", "given": "Neville", "initials": "N", "orcid": "0000-0003-1800-2103", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b1ec37c898746abb5adc2a199f1ecf7.json"}}, {"family": "AbdAllah", "given": "AbdelHalim", "initials": "A", "orcid": "0000-0002-3441-9219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d660b25c91547e58020fb1aaad3f931.json"}}, {"family": "Abad", "given": "Neetu", "initials": "N", "orcid": "0000-0001-6999-4494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70cf4e5207a6403493e3490748c873ac.json"}}, {"family": "Ahmed", "given": "Naglaa", "initials": "N", "orcid": "0000-0003-3255-3948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e330ae7279149a9a88919e762a7d266.json"}}, {"family": "Albarracin", "given": "Dolores", "initials": "D", "orcid": "0000-0002-9575-1637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54e3e6521de74104ae67ec4abbe5b9da.json"}}, {"family": "Altieri", "given": "Elena", "initials": "E", "orcid": "0000-0001-6603-3399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a71adae43bdb435d9a282a876d7e33a7.json"}}, {"family": "Anoko", "given": "Julienne N", "initials": "JN", "orcid": "0000-0002-5436-311X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a355367e6c34aac9627c54c755c0005.json"}}, {"family": "Arcos", "given": "Ruben", "initials": "R", "orcid": "0000-0002-9665-5874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5f8621e19e94647b28a1ba01330da9d.json"}}, {"family": "Azlan", "given": "Arina Anis", "initials": "AA", "orcid": "0000-0001-5484-1188", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2510a9cda05d4bcf93be48fd0ed13525.json"}}, {"family": "Bayer", "given": "Judit", "initials": "J", "orcid": "0000-0003-0558-807X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7637e48fa0440a8b7e44d080339d552.json"}}, {"family": "Bechmann", "given": "Anja", "initials": "A", "orcid": "0000-0002-5588-5155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d144b5ff2fa74ce9ba8a5b01ecfd0f9f.json"}}, {"family": "Bezbaruah", "given": "Supriya", "initials": "S", "orcid": "0000-0002-4064-1297", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5601786cb9ce4e6fa0d71a5c493621ed.json"}}, {"family": "Briand", "given": "Sylvie C", "initials": "SC", "orcid": "0000-0001-6929-5335", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51ec51b7d86249469922ee9bf2b25c63.json"}}, {"family": "Brooks", "given": "Ian", "initials": "I", "orcid": "0000-0002-3793-3635", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bb0c9e7af664aff9ae71eb5d11a1872.json"}}, 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"Trewinnard", "given": "Tom", "initials": "T", "orcid": "0000-0001-7457-1322", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/360ee67acf5d4c31a8a2873c959bdac5.json"}}, {"family": "Turner", "given": "Shannon", "initials": "S", "orcid": "0000-0001-7425-3607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1df1ce4911eb47c9b4e0dbb4d7b8d058.json"}}, {"family": "Tworek", "given": "Heidi", "initials": "H", "orcid": "0000-0001-8825-7895", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b2de2bd58fc4c61b1b452d99c58d437.json"}}, {"family": "Uakkas", "given": "Saad", "initials": "S", "orcid": "0000-0001-6850-9901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9fbb96caef9a4c06831fa53fe57551bb.json"}}, {"family": "Vraga", "given": "Emily", "initials": "E", "orcid": "0000-0002-3016-3869", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb4c3fa0e0724326bdce31886a98011f.json"}}, {"family": "Wardle", "given": "Claire", "initials": "C", "orcid": "0000-0003-4597-8574", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72fd5fef1e8d4936ad46dbfba4004150.json"}}, {"family": "Wasserman", "given": "Herman", "initials": "H", "orcid": "0000-0002-2553-1989", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e43d8563aabc4fdb9dd23f5061226687.json"}}, {"family": "Wilhelm", "given": "Elisabeth", "initials": "E", "orcid": "0000-0002-4641-516X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd5af5af0a8348259121ef1a07fd5d61.json"}}, {"family": "W\u00fcrz", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3371-2736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4f15dda255248aea3ad25bbd7e6f035.json"}}, {"family": "Yau", "given": "Brian", "initials": "B", "orcid": "0000-0003-4255-9243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2178627e893c4a6a877dbbd168aa441b.json"}}, {"family": "Zhou", "given": "Lei", "initials": "L", "orcid": "0000-0002-6640-0774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98aff1a8ad36481c88971dcdc2cefcb8.json"}}, {"family": "Purnat", "given": "Tina D", "initials": "TD", "orcid": "0000-0002-0257-6631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a36f3dacd5946868c9e0ed41002c266.json"}}], "type": "journal article", "published": "2021-09-15", "journal": {"title": "JMIR Infodemiology", "issn": "2564-1891", "volume": "1", "issue": "1", "pages": "e30979", "issn-l": null}, "abstract": "An infodemic is an overflow of information of varying quality that surges across digital and physical environments during an acute public health event. It leads to confusion, risk-taking, and behaviors that can harm health and lead to erosion of trust in health authorities and public health responses. Owing to the global scale and high stakes of the health emergency, responding to the infodemic related to the pandemic is particularly urgent. Building on diverse research disciplines and expanding the discipline of infodemiology, more evidence-based interventions are needed to design infodemic management interventions and tools and implement them by health emergency responders.\n\nThe World Health Organization organized the first global infodemiology conference, entirely online, during June and July 2020, with a follow-up process from August to October 2020, to review current multidisciplinary evidence, interventions, and practices that can be applied to the COVID-19 infodemic response. This resulted in the creation of a public health research agenda for managing infodemics.\n\nAs part of the conference, a structured expert judgment synthesis method was used to formulate a public health research agenda. A total of 110 participants represented diverse scientific disciplines from over 35 countries and global public health implementing partners. The conference used a laddered discussion sprint methodology by rotating participant teams, and a managed follow-up process was used to assemble a research agenda based on the discussion and structured expert feedback. This resulted in a five-workstream frame of the research agenda for infodemic management and 166 suggested research questions. The participants then ranked the questions for feasibility and expected public health impact. The expert consensus was summarized in a public health research agenda that included a list of priority research questions.\n\nThe public health research agenda for infodemic management has five workstreams: (1) measuring and continuously monitoring the impact of infodemics during health emergencies; (2) detecting signals and understanding the spread and risk of infodemics; (3) responding and deploying interventions that mitigate and protect against infodemics and their harmful effects; (4) evaluating infodemic interventions and strengthening the resilience of individuals and communities to infodemics; and (5) promoting the development, adaptation, and application of interventions and toolkits for infodemic management. Each workstream identifies research questions and highlights 49 high priority research questions.\n\nPublic health authorities need to develop, validate, implement, and adapt tools and interventions for managing infodemics in acute public health events in ways that are appropriate for their countries and contexts. Infodemiology provides a scientific foundation to make this possible. This research agenda proposes a structured framework for targeted investment for the scientific community, policy makers, implementing organizations, and other stakeholders to consider.", "doi": "10.2196/30979", "pmid": "34604708", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "v1i1e30979"}, {"db": "pmc", "key": "PMC8448461"}], "notes": [], "created": "2021-10-11T18:01:06.780Z", "modified": "2021-10-11T18:01:08.959Z"}, {"entity": "publication", "iuid": "423363b4198b4e769954473f1692fc8f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/423363b4198b4e769954473f1692fc8f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/423363b4198b4e769954473f1692fc8f"}}, "title": "Systemic Human Neutrophil Lipocalin Associates with Severe Acute Kidney Injury in SARS-CoV-2 Pneumonia.", "authors": [{"family": "B\u00fclow Anderberg", "given": "Sara", "initials": "S"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Eriksson", "given": "Ann-Katrin", "initials": "A"}, {"family": "Venge", "given": "Per", "initials": "P"}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}], "type": "journal article", "published": "2021-09-14", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "10", "issue": "18", "pages": null}, "abstract": "Neutrophils have been suggested mediators of organ dysfunction in COVID-19. The current study investigated if systemic neutrophil activity, estimated by human neutrophil lipocalin (HNL) concentration in peripheral blood, is associated with acute kidney injury (AKI) development. A total of 103 adult patients admitted to intensive care, with PCR-confirmed SARS-CoV-2 infection, were prospectively included (Clinical Trials ID: NCT04316884). HNL was analyzed in plasma (P-HNL Dimer) and in whole blood (B-HNL). The latter after ex vivo activation with N-formyl-methionine-leucine-phenylalanine. All patients developed respiratory dysfunction and 62 (60%) were treated with invasive ventilation. Sixty-seven patients (65%) developed AKI, 18 (17%) progressed to AKI stage 3, and 14 (14%) were treated with continuous renal replacement therapy (CRRT). P-HNL Dimer was higher in patients with invasive ventilation, vasopressors, AKI, AKI stage 3, dialysis, and 30-day mortality (p < 0.001-0.046). B-HNL performed similarly with the exception of mild AKI and mortality (p < 0.001-0.004). The cohort was dichotomized by ROC estimated cutoff concentrations of 13.2 \u00b5g/L and 190 \u00b5g/L for P-HNL Dimer and B-HNL respectively. Increased cumulative risks for AKI, AKI stage 3, and death were observed if above the P-HNL cutoff and for AKI stage 3 if above the B-HNL cutoff. The relative risk of developing AKI stage 3 was nine and 39 times greater if above the cutoffs in plasma and whole blood, respectively, for CRRT eight times greater for both. In conclusion, systemically elevated neutrophil lipocalin, interpreted as increased neutrophil activity, was shown to be associated with an increased risk of severe AKI, renal replacement therapy, and mortality in COVID-19 patients with respiratory failure.", "doi": "10.3390/jcm10184144", "pmid": "34575252", "labels": {"Funder: VR": null, "Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "jcm10184144"}, {"db": "pmc", "key": "PMC8464787"}], "notes": [], "created": "2021-10-11T18:05:16.167Z", "modified": "2022-02-08T19:26:20.749Z"}, {"entity": "publication", "iuid": "8ba2f975b4274347abb1c16e6fdb96ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ba2f975b4274347abb1c16e6fdb96ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ba2f975b4274347abb1c16e6fdb96ef"}}, "title": "COVID-19 in Pregnancy and Early Childhood (COPE): study protocol for a prospective, multicentre biobank, survey and database cohort study.", "authors": [{"family": "Carlsson", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-1414-7279", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2453802e12b43008382f79aebd51ddf.json"}}, {"family": "Bergman", "given": "Lina", "initials": "L", "orcid": "0000-0001-5202-9428", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/edca37463d7c49c79fcdd7793717e1a1.json"}}, {"family": "Zaigham", "given": "Mehreen", "initials": "M", "orcid": "0000-0003-0129-1578", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/168018c2beee4b99868263d77bb67277.json"}}, {"family": "Linden", "given": "Karolina", "initials": "K", "orcid": "0000-0002-2792-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a16575cbdf5a4e0ebab52acaf2404273.json"}}, {"family": "Andersson", "given": "Ola", "initials": "O", "orcid": "0000-0002-3972-0457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77b8a87b252041f094508255b8a43df5.json"}}, {"family": "Veje", "given": "Malin", "initials": "M", "orcid": "0000-0001-5487-0616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de2e59c2ebcf41759a06fda11b6572bd.json"}}, {"family": "Sandstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Wikstr\u00f6m", "given": "Anna-Karin", "initials": "AK"}, {"family": "\u00d6stling", "given": "Hanna", "initials": "H"}, {"family": "Fadl", "given": "Helena", "initials": "H", "orcid": "0000-0002-2691-7525", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18fc6fdc8fee43348cd4283b0ad6334a.json"}}, {"family": "Domell\u00f6f", "given": "Magnus", "initials": "M", "orcid": "0000-0002-0726-7029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8aa25e36cc840e59e8308b8cca886c6.json"}}, {"family": "Blomberg", "given": "Marie", "initials": "M", "orcid": "0000-0003-4679-550X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa8f5a1024fe4cd1b8439ebef8d600c1.json"}}, {"family": "Brismar Wendel", "given": "Sophia", "initials": "S", "orcid": "0000-0002-9401-8062", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bfdd5280d71344dab0a68a2f4a4a2a99.json"}}, {"family": "\u00c5den", "given": "Ulrika", "initials": "U"}, {"family": "Sengpiel", "given": "Verena", "initials": "V", "orcid": "0000-0002-3608-7430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d43b587b94df49f88177d0c804ba7688.json"}}, {"family": "COPE study group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-09-14", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "9", "pages": "e049376", "issn-l": "2044-6055"}, "abstract": "There is limited knowledge on how the SARS-CoV-2 affects pregnancy outcomes. Studies investigating the impact of COVID-19 in early pregnancy are scarce and information on long-term follow-up is lacking.The purpose of this project is to study the impact of COVID-19 on pregnancy outcomes and long-term maternal and child health by: (1) establishing a database and biobank from pregnant women with COVID-19 and presumably non-infected women and their infants and (2) examining how women and their partners experience pregnancy, childbirth and early parenthood in the COVID-19 pandemic.\n\nThis is a national, multicentre, prospective cohort study involving 27 Swedish maternity units accounting for over 86 000 deliveries/year. Pregnant women are included when they: (1) test positive for SARS-CoV-2 (COVID-19 group) or (2) are non-infected and seek healthcare at one of their routine antenatal visits (screening group). Blood, as well as other biological samples, are collected at different time points during and after pregnancy. Child health up to 4 years of age and parent experience of pregnancy, delivery, early parenthood, healthcare and society in general will be examined using web-based questionnaires based on validated instruments. Short- and long-term health outcomes will be collected from Swedish health registers and the parents' experiences will be studied by performing qualitative interviews.\n\nConfidentiality aspects such as data encryption and storage comply with the General Data Protection Regulation and with ethical committee requirements. This study has been granted national ethical approval by the Swedish Ethical Review Authority (dnr 2020-02189 and amendments 2020-02848, 2020-05016, 2020-06696 and 2021-00870) and national biobank approval by the Biobank V\u00e4st (dnr B2000526:970). Results from the project will be published in peer-reviewed journals.\n\nNCT04433364.", "doi": "10.1136/bmjopen-2021-049376", "pmid": "34521667", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-049376"}, {"db": "pmc", "key": "PMC8441224"}, {"db": "ClinicalTrials.gov", "key": "NCT04433364"}], "notes": [], "created": "2021-09-20T06:23:16.618Z", "modified": "2021-11-19T10:46:33.086Z"}, {"entity": "publication", "iuid": "2893acfc94114a48bcf216469cf5f57e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2893acfc94114a48bcf216469cf5f57e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2893acfc94114a48bcf216469cf5f57e"}}, "title": "The SARS-CoV-2 spike protein is vulnerable to moderate electric fields.", "authors": [{"family": "Arbeitman", "given": "Claudia R", "initials": "CR", "orcid": "0000-0002-8302-6825", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e7be9f3366648e89aabf1604b071cfe.json"}}, {"family": "Rojas", "given": "Pablo", "initials": "P", "orcid": "0000-0003-3692-9228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee970dfd751549f2ab345dc82dfe7ced.json"}}, {"family": "Ojeda-May", "given": "Pedro", "initials": "P"}, {"family": "Garcia", "given": "Martin E", "initials": "ME", "orcid": "0000-0003-2418-1902", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/001e21f8f9c64da19ba99f3e5d3baaed.json"}}], "type": "journal article", "published": "2021-09-13", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "5407", "issn-l": "2041-1723"}, "abstract": "Most of the ongoing projects aimed at the development of specific therapies and vaccines against COVID-19 use the SARS-CoV-2 spike (S) protein as the main target. The binding of the spike protein with the ACE2 receptor (ACE2) of the host cell constitutes the first and key step for virus entry. During this process, the receptor binding domain (RBD) of the S protein plays an essential role, since it contains the receptor binding motif (RBM), responsible for the docking to the receptor. So far, mostly biochemical methods are being tested in order to prevent binding of the virus to ACE2. Here we show, with the help of atomistic simulations, that external electric fields of easily achievable and moderate strengths can dramatically destabilise the S protein, inducing long-lasting structural damage. One striking field-induced conformational change occurs at the level of the recognition loop L3 of the RBD where two parallel beta sheets, believed to be responsible for a high affinity to ACE2, undergo a change into an unstructured coil, which exhibits almost no binding possibilities to the ACE2 receptor. We also show that these severe structural changes upon electric-field application also occur in the mutant RBDs corresponding to the variants of concern (VOC) B.1.1.7 (UK), B.1.351 (South Africa) and P.1 (Brazil). Remarkably, while the structural flexibility of S allows the virus to improve its probability of entering the cell, it is also the origin of the surprising vulnerability of S upon application of electric fields of strengths at least two orders of magnitude smaller than those required for damaging most proteins. Our findings suggest the existence of a clean physical method to weaken the SARS-CoV-2 virus without further biochemical processing. Moreover, the effect could be used for infection prevention purposes and also to develop technologies for in-vitro structural manipulation of S. Since the method is largely unspecific, it can be suitable for application to other mutations in S, to other proteins of SARS-CoV-2 and in general to membrane proteins of other virus types.", "doi": "10.1038/s41467-021-25478-7", "pmid": "34518528", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-25478-7"}], "notes": [], "created": "2021-09-20T06:28:51.640Z", "modified": "2021-09-20T06:29:03.724Z"}, {"entity": "publication", "iuid": "1e64f19ee90a4d2ea6e4270ab56bdc03", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1e64f19ee90a4d2ea6e4270ab56bdc03.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1e64f19ee90a4d2ea6e4270ab56bdc03"}}, "title": "Psychometric Properties of the Fear of COVID-19 Scale: a Response to Mercado-Lara et al. \"Validity and Reliability of the Spanish Version of Fear of COVID-19 Scale in Colombian Physicians\".", "authors": [{"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "editorial", "published": "2021-09-13", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "pages": "1-3", "issn-l": null}, "abstract": "A paper reporting the psychometric properties of the Spanish Fear of COVID-19 Scale (FCV-19S) among Colombian physicians was recently published in the International Journal of Mental Health and Addiction. Although we welcome the translation and validation of our seven-item scale, this commentary outlines some major concerns we have with the study especially the removal of two items in developing a five-item FCV-19S. Based on these concerns, we strongly recommend that healthcare providers and researchers should use the five-item FCV-19S with caution.", "doi": "10.1007/s11469-021-00635-7", "pmid": "34539280", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "635"}, {"db": "pmc", "key": "PMC8436576"}], "notes": [], "created": "2021-10-10T15:34:42.465Z", "modified": "2021-10-10T15:34:42.495Z"}, {"entity": "publication", "iuid": "d23a819098cf4ae290dac7d35a599b0d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d23a819098cf4ae290dac7d35a599b0d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d23a819098cf4ae290dac7d35a599b0d"}}, "title": "Drawing lessons from the COVID-19 pandemic: Seven obstacles to learning from public inquiries in the wake of the crisis.", "authors": [{"family": "Eriksson", "given": "Kerstin", "initials": "K", "orcid": "0000-0002-0494-0089", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5167d81d812b4c479914399d0906560e.json"}}, {"family": "Staupe-Delgado", "given": "Reidar", "initials": "R", "orcid": "0000-0002-4244-9725", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8585167cd5824e429f1974ebbb254856.json"}}, {"family": "Holst", "given": "J\u00f8rgen", "initials": "J", "orcid": "0000-0001-7850-4493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4cef8db2e53049dcb56e3b94a40ae28d.json"}}], "type": "journal article", "published": "2021-09-13", "journal": {"title": "Risk Hazards Crisis Public Policy", "issn": "1944-4079", "issn-l": null}, "abstract": "On March 11, 2020, the World Health Organization declared the emerging COVID-19 threat a pandemic following the global spread of the virus. A year later, a number of governments are being handed the concluding reports of national public inquiries tasked with investigating responses, mishaps, and identifying lessons for the future. The present article aims to identify a set of learning obstacles that may hinder effective lessons drawing from the COVID-19 pandemic responses. The seven obstacles discussed in this article are: (1) retaining lessons and implementing them effectively, (2) effectively drawing lessons from other countries, (3) the potential for reforms to introduce unanticipated vulnerabilities elsewhere in the system, (4) political pressure, (5) drawing the conclusions from observations, (6) experts versus decision makers, and (7) reforms may not be related to the actual crisis. Exploring these obstacles will be central to future discussions concerning which kinds of responses will set precedent for future pandemics and global health crises.", "doi": "10.1002/rhc3.12240", "pmid": "34909110", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "RHC312240"}, {"db": "pmc", "key": "PMC8662287"}], "notes": [], "created": "2021-12-18T17:50:37.507Z", "modified": "2021-12-18T17:50:52.983Z"}, {"entity": "publication", "iuid": "58eb98e7c803402b8707615116755540", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/58eb98e7c803402b8707615116755540.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/58eb98e7c803402b8707615116755540"}}, "title": "Correction to: The Unyvero Hospital-Acquired pneumonia panel for diagnosis of secondary bacterial pneumonia in COVID-19 patients.", "authors": [{"family": "Tellapragada", "given": "Chaitanya", "initials": "C"}, {"family": "Giske", "given": "Christian G", "initials": "CG"}], "type": "published erratum", "published": "2021-09-13", "journal": {"title": "Eur J Clin Microbiol Infect Dis", "issn": "1435-4373", "issn-l": null}, "abstract": null, "doi": "10.1007/s10096-021-04331-1", "pmid": "34515876", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10096-021-04331-1"}, {"db": "pmc", "key": "PMC8435560"}], "notes": [], "created": "2021-09-20T06:29:31.711Z", "modified": "2021-09-20T06:30:31.524Z"}, {"entity": "publication", "iuid": "46682de72d7b45ba9a99097ebadafc6a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46682de72d7b45ba9a99097ebadafc6a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46682de72d7b45ba9a99097ebadafc6a"}}, "title": "COVID-19 infection among bartenders and waiters before and after pub lockdown.", "authors": [{"family": "Methi", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-7091-0806", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb34bc6f3c664b55b2240d9de0114cd4.json"}}, {"family": "Telle", "given": "Kjetil", "initials": "K"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2021-09-11", "journal": {"title": "Occup Environ Med", "issn": "1470-7926", "issn-l": null}, "abstract": "To assess how different bans on serving alcohol in Norwegian bars and restaurants were related to the detection of SARS-CoV-2 in bartenders and waiters and in persons in any occupation.\n\nIn 25 392 bartenders and waiters and 1 496 328 persons with other occupations (mean (SD) age 42.0 (12.9) years and 51.8% men), we examined the weekly rates of workers tested and detected with SARS-CoV-2, 1-10 weeks before and 1-5 weeks after implementation of different degrees of bans on serving alcohol in pubs and restaurants, across 102 Norwegian municipalities with: (1) full blanket ban, (2) partial ban with hourly restrictions (eg, from 22:00 hours) or (3) no ban, adjusted for age, sex, testing behaviour and population size.\n\nBy 4 weeks after the implementation of ban, COVID-19 infection among bartenders and waiters had been reduced by 60% (from 2.8 (95% CI 2.0 to 3.6) to 1.1 (95% CI 0.5 to 1.6) per 1000) in municipalities introducing full ban, and by almost 50% (from 2.5 (95% CI 1.5 to 3.5) to 1.3 (95% CI 0.4 to 2.2) per 1000) in municipalities introducing partial ban. A similar reduction within 4 weeks was also observed for workers in all occupations, both in municipalities with full (from 1.3 (95% CI 1.3 to 1.4) to 0.9 (95% CI 0.9 to 1.0)) and partial bans (from 1.2 (95% CI 1.1 to 1.3) to 0.5 (95% CI 0.5 to 0.6)).\n\nPartial bans on serving alcohol in bars and restaurants may be similarly associated with declines in confirmed COVID-19 infection as full bans.", "doi": "10.1136/oemed-2021-107502", "pmid": "34510004", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "oemed-2021-107502"}], "notes": [], "created": "2021-09-13T06:32:35.717Z", "modified": "2021-11-18T14:19:01.530Z"}, {"entity": "publication", "iuid": "1cb49e2c4e4246f1b9d225c6f4207247", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1cb49e2c4e4246f1b9d225c6f4207247.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1cb49e2c4e4246f1b9d225c6f4207247"}}, "title": "Unmet need of essential treatments for critical illness in Malawi.", "authors": [{"family": "Kayambankadzanja", "given": "Raphael Kazidule", "initials": "RK", "orcid": "0000-0003-2242-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48591b6c1f8c46b6ad8750de157c98a3.json"}}, {"family": "Schell", "given": "Carl Otto", "initials": "CO", "orcid": "0000-0002-7904-1336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a40b337b45b471d97a102c355c9d874.json"}}, {"family": "Mbingwani", "given": "Isaac", "initials": "I"}, {"family": "Mndolo", "given": "Samson Kwazizira", "initials": "SK"}, {"family": "Castegren", "given": "Markus", "initials": "M"}, {"family": "Baker", "given": "Tim", "initials": "T"}], "type": "journal article", "published": "2021-09-10", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "9", "pages": "e0256361"}, "abstract": "Critical illness is common throughout the world and has been the focus of a dramatic increase in attention during the COVID-19 pandemic. Severely deranged vital signs such as hypoxia, hypotension and low conscious level can identify critical illness. These vital signs are simple to check and treatments that aim to correct derangements are established, basic and low-cost. The aim of the study was to estimate the unmet need of such essential treatments for severely deranged vital signs in all adults admitted to hospitals in Malawi.\r\n\r\nWe conducted a point prevalence cross-sectional study of adult hospitalized patients in Malawi. All in-patients aged \u226518 on single days Queen Elizabeth Central Hospital (QECH) and Chiradzulu District Hospital (CDH) were screened. Patients with hypoxia (oxygen saturation <90%), hypotension (systolic blood pressure <90mmHg) and reduced conscious level (Glasgow Coma Scale <9) were included in the study. The a-priori defined essential treatments were oxygen therapy for hypoxia, intravenous fluid for hypotension and an action to protect the airway for reduced consciousness (placing the patient in the lateral position, insertion of an oro-pharyngeal airway or endo-tracheal tube or manual airway protection).\r\n\r\nOf the 1135 hospital in-patients screened, 45 (4.0%) had hypoxia, 103 (9.1%) had hypotension, and 17 (1.5%) had a reduced conscious level. Of those with hypoxia, 40 were not receiving oxygen (88.9%). Of those with hypotension, 94 were not receiving intravenous fluids (91.3%). Of those with a reduced conscious level, nine were not receiving an action to protect the airway (53.0%).\r\n\r\nThere was a large unmet need of essential treatments for critical illness in two hospitals in Malawi.", "doi": "10.1371/journal.pone.0256361", "pmid": "34506504", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-08206"}], "notes": [], "created": "2021-09-13T06:26:05.344Z", "modified": "2021-11-18T14:18:20.046Z"}, {"entity": "publication", "iuid": "d39b885aacba463da071d6ea31343e2a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d39b885aacba463da071d6ea31343e2a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d39b885aacba463da071d6ea31343e2a"}}, "title": "Outcomes associated with different vaccines in individuals with bipolar disorder and impact on the current COVID-19 pandemic- a systematic review.", "authors": [{"family": "Reininghaus", "given": "Eva Z", "initials": "EZ"}, {"family": "Manchia", "given": "Mirko", "initials": "M"}, {"family": "Dalkner", "given": "Nina", "initials": "N"}, {"family": "Bonkat", "given": "Nina", "initials": "N"}, {"family": "Squassina", "given": "Alessio", "initials": "A"}, {"family": "Hodl", "given": "Isabel", "initials": "I"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Reif", "given": "Andreas", "initials": "A"}, {"family": "Hajek", "given": "Tomas", "initials": "T"}, {"family": "Land\u00e9n", "given": "Mikael", "initials": "M"}, {"family": "Correll", "given": "Christoph U", "initials": "CU"}, {"family": "Scott", "given": "Jan", "initials": "J"}, {"family": "Etain", "given": "Bruno", "initials": "B"}, {"family": "Rietschel", "given": "Marcella", "initials": "M"}, {"family": "Bergink", "given": "Veerle", "initials": "V"}, {"family": "Martinez-Cengotitabengoa", "given": "Monica", "initials": "M"}, {"family": "Kessing", "given": "Lars Vedel", "initials": "LV"}, {"family": "Fagiolini", "given": "Andrea", "initials": "A"}, {"family": "Bauer", "given": "Michael", "initials": "M"}, {"family": "Goodwin", "given": "Guy", "initials": "G"}, {"family": "Gonzalez-Pinto", "given": "Ana", "initials": "A"}, {"family": "Kupka", "given": "Ralph W", "initials": "RW"}, {"family": "Schulze", "given": "Thomas G", "initials": "TG"}, {"family": "Lagerberg", "given": "Trine V", "initials": "TV"}, {"family": "Yildiz", "given": "Ay\u015feg\u00fcl", "initials": "A"}, {"family": "Henry", "given": "Chantal", "initials": "C"}, {"family": "Morken", "given": "Gunnar", "initials": "G"}, {"family": "Ritter", "given": "Phillip", "initials": "P"}, {"family": "Nieslen", "given": "Ren\u00e9 Ernst", "initials": "RE"}, {"family": "Licht", "given": "Rasmus W", "initials": "RW"}, {"family": "Bechdolf", "given": "Andreas", "initials": "A"}, {"family": "Andreassen", "given": "Ole A", "initials": "OA"}, {"family": "Fellendorf", "given": "Frederike Tabea", "initials": "FT"}], "type": "journal article", "published": "2021-09-10", "journal": {"title": "Eur Neuropsychopharmacol", "issn": "1873-7862", "issn-l": null}, "abstract": "Bipolar disorder (BD) might be associated with higher infection rates of coronavirus disease (COVID-19) which in turn could result in worsening the clinical course and outcome. This may be due to a high prevalence of somatic comorbidities and an increased risk of delays in and poorer treatment of somatic disease in patients with severe mental illness in general. Vaccination is the most important public health intervention to tackle the ongoing pandemic. We undertook a systematic review regarding the data on vaccinations in individuals with BD. Proportion of prevalence rates, efficacy and specific side effects of vaccinations and in individuals with BD were searched. Results show that only five studies have investigated vaccinations in individuals with BD, which substantially limits the interpretation of overall findings. Studies on antibody production after vaccinations in BD are very limited and results are inconsistent. Also, the evidence-based science on side effects of vaccinations in individuals with BD so far is poor.", "doi": "10.1016/j.euroneuro.2021.09.001", "pmid": "34607722", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0924-977X(21)00743-4"}, {"db": "pmc", "key": "PMC8429356"}], "notes": [], "created": "2021-10-11T17:55:05.232Z", "modified": "2021-10-11T17:55:05.250Z"}, {"entity": "publication", "iuid": "6cdab3b8bf64424e8314f89437a1daf2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6cdab3b8bf64424e8314f89437a1daf2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6cdab3b8bf64424e8314f89437a1daf2"}}, "title": "Histone H3 Cleavage in Severe COVID-19 ICU Patients.", "authors": [{"family": "Huckriede", "given": "Joram", "initials": "J"}, {"family": "de Vries", "given": "Femke", "initials": "F"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Wichapong", "given": "Kanin", "initials": "K"}, {"family": "Reutelingsperger", "given": "Chris", "initials": "C"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Garcia de Frutos", "given": "Pablo", "initials": "P"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Nicolaes", "given": "Gerry A F", "initials": "GAF"}], "type": "journal article", "published": "2021-09-10", "journal": {"title": "Front Cell Infect Microbiol", "issn": "2235-2988", "volume": "11", "pages": "694186", "issn-l": null}, "abstract": "The severity of coronavirus disease 19 (COVID-19) is associated with neutrophil extracellular trap (NET) formation. During NET formation, cytotoxic extracellular histones are released, the presence of which is linked to the initiation and progression of several acute inflammatory diseases. Here we study the presence and evolution of extracellular histone H3 and several other neutrophil-related molecules and damage-associated molecular patterns (DAMPs) in the plasma of 117 COVID-19-positive ICU patients. We demonstrate that at ICU admission the levels of histone H3, MPO, and DNA-MPO complex were all significantly increased in COVID-19-positive patients compared to control samples. Furthermore, in a subset of 54 patients, the levels of each marker remained increased after 4+ days compared to admission. Histone H3 was found in 28% of the patients on admission to the ICU and in 50% of the patients during their stay at the ICU. Notably, in 47% of histone-positive patients, we observed proteolysis of histone in their plasma. The overall presence of histone H3 during ICU stay was associated with thromboembolic events and secondary infection, and non-cleaved histone H3 was associated with the need for vasoactive treatment, invasive ventilation, and the development of acute kidney injury. Our data support the validity of treatments that aim to reduce NET formation and additionally underscore that more targeted therapies focused on the neutralization of histones should be considered as treatment options for severe COVID-19 patients.", "doi": "10.3389/fcimb.2021.694186", "pmid": "34568088", "labels": {"Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8461091"}], "notes": [], "created": "2021-10-11T18:03:16.463Z", "modified": "2021-10-11T18:03:16.478Z"}, {"entity": "publication", "iuid": "a92858c94ac44fe49013e243adcdf3fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a92858c94ac44fe49013e243adcdf3fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a92858c94ac44fe49013e243adcdf3fd"}}, "title": "A potential increase in adolescent nonsuicidal self-injury during covid-19: A comparison of data from three different time points during 2011 - 2021.", "authors": [{"family": "Zetterqvist", "given": "Maria", "initials": "M"}, {"family": "Jonsson", "given": "Linda S", "initials": "LS"}, {"family": "Landberg", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Svedin", "given": "Carl G\u00f6ran", "initials": "CG"}], "type": "journal article", "published": "2021-09-10", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "volume": "305", "pages": "114208", "issn-l": null}, "abstract": "Life-time prevalence of nonsuicidal self-injury (NSSI) has consistently been found to be around 17% in community samples of adolescents. Concerns of threats to mental health in adolescents during covid-19 have been raised. Life-time prevalence of NSSI in high school students in Sweden was compared using the same item to assess NSSI at three different time points. Results showed very similar prevalence of NSSI in 2011 and 2014 (17.2 % vs. 17.7 %), and an increase to 27.6 % during the pandemic of 2020-2021. Our findings imply a need to highlight the potential psychosocial consequences of covid-19 for young people.", "doi": "10.1016/j.psychres.2021.114208", "pmid": "34543849", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(21)00504-7"}, {"db": "pmc", "key": "PMC8448460"}], "notes": [], "created": "2021-10-10T15:37:09.274Z", "modified": "2021-10-10T15:37:09.284Z"}, {"entity": "publication", "iuid": "db528e826ef244f692dd82d08ecb0d8c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db528e826ef244f692dd82d08ecb0d8c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db528e826ef244f692dd82d08ecb0d8c"}}, "title": "Older adults' experiences of maintaining social participation: Creating opportunities and striving to adapt to changing situations.", "authors": [{"family": "L\u00f6fgren", "given": "Maria", "initials": "M", "orcid": "0000-0002-2403-4761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7013c636d1cb4a6f8e7e9e9ff51123f1.json"}}, {"family": "Larsson", "given": "Ellinor", "initials": "E", "orcid": "0000-0001-8513-0338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ced25f9687c3468ea8bbad6c8d0d23bd.json"}}, {"family": "Isaksson", "given": "Gunilla", "initials": "G", "orcid": "0000-0001-9143-9235", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a9d964a11714d6d86d6c163b645209e.json"}}, {"family": "Nyman", "given": "Anneli", "initials": "A", "orcid": "0000-0003-0467-4857", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48287349613a4cbb92e6023e9c18c335.json"}}], "type": "journal article", "published": "2021-09-09", "journal": {"title": "Scand J Occup Ther", "issn": "1651-2014", "pages": "1-11", "issn-l": null}, "abstract": "Social participation concerns the possibility of engaging in activities in interaction with others or society at large and contributes to the health and well-being of older adults. In contrast, a lack of social participation is associated with loneliness. It is, therefore, important to understand what strategies older adults use to maintain social participation.\n\nTo explore and describe older adults' experiences of maintaining social participation.\n\nNine older adults, aged 69-92 years, participated in interviews that were analysed through qualitative content analysis.\n\nThe overall findings reflect how older adults create opportunities for social participation by developing strategies and striving to adapt to changing situations, emphasizing how maintaining social participation is an active process. Preserving social participation requires motivation and an effort to take initiative to cultivate social relations, maintain community bonds, engage in social events and activities and stay connected with society.\n\nThese results may extend our understanding of strategies that older adults use, as well as the challenges they face when striving to adapt to new circumstances. This study may have implications for the practice of how to support older adults' social participation.", "doi": "10.1080/11038128.2021.1974550", "pmid": "34499845", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-09-13T06:07:30.008Z", "modified": "2021-09-13T06:07:30.131Z"}, {"entity": "publication", "iuid": "61b81c8d424d47928971c9d88be29179", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61b81c8d424d47928971c9d88be29179.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61b81c8d424d47928971c9d88be29179"}}, "title": "Heterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination", "authors": [{"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Vikstr\u00f6m", "given": "Linnea", "initials": "L"}, {"family": "Gwon", "given": "Yong Dae", "initials": "YD"}, {"family": "Persson", "given": "Ida Lisa", "initials": "IL"}, {"family": "Edin", "given": "Alicia", "initials": "A"}, {"family": "Bj\u00f6rsell", "given": "Tove", "initials": "T"}, {"family": "Dernstedt", "given": "Andy", "initials": "A"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Tevell", "given": "Staffan", "initials": "S"}, {"family": "Evander", "given": "Magnus", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Forsell", "given": "Mattias", "initials": "M", "orcid": "0000-0001-6904-742X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e41c0e1c9c7b499fb3d844d4c572e7bb.json"}}], "type": "journal-article", "published": "2021-09-09", "journal": {"title": "N Engl J Med", "issn": "1533-4406", "issn-l": null, "volume": "385", "issue": "11", "pages": "1049-1051"}, "abstract": null, "doi": "10.1056/nejmc2110716", "pmid": "34260850", "labels": {"Research Area: Vaccine": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Drug Discovery": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC8314734"}], "notes": [], "created": "2021-08-16T14:53:53.615Z", "modified": "2022-02-14T16:26:28.301Z"}, {"entity": "publication", "iuid": "6b6cc99a371b49e892efedf3224ad53d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b6cc99a371b49e892efedf3224ad53d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b6cc99a371b49e892efedf3224ad53d"}}, "title": "Patients with autoimmune polyendocrine syndrome type 1 have an increased susceptibility to severe herpesvirus infections.", "authors": [{"family": "Iivo", "given": "Hetem\u00e4ki", "initials": "H"}, {"family": "Saila", "given": "Laakso", "initials": "L"}, {"family": "Hannamari", "given": "V\u00e4limaa", "initials": "V"}, {"family": "Kleino", "given": "Iivari", "initials": "I"}, {"family": "Kek\u00e4l\u00e4inen", "given": "Eliisa", "initials": "E"}, {"family": "Outi", "given": "M\u00e4kitie", "initials": "M"}, {"family": "Petteri", "given": "Arstila T", "initials": "AT"}], "type": "journal article", "published": "2021-09-08", "journal": {"title": "Clin Immunol", "issn": "1521-7035", "pages": "108851", "issn-l": "1521-6616"}, "abstract": "Almost all patients with autoimmune polyendocrine syndrome type 1 (APS-1) have neutralizing antibodies against type 1 interferons (IFN), important mediators of antiviral defense. Recently, neutralizing anti-IFN antibodies were shown to be a risk factor of severe COVID-19. Here we show in a cohort of 44 patients with APS-1 that higher titers of neutralizing anti-IFN\u03b14 antibodies are associated with a higher and earlier incidence of VZV reactivation (herpes zoster). The patients also present with uncommonly severe clinical sequelae of herpetic infections. APS-1 patients had decreased humoral immune responses to varicella zoster virus, but cellular responses were comparable to healthy controls. These results suggest that blocking the type I interferon pathway in patients with APS-1 patients leads to a clinically significant immune deficiency, and susceptibility to herpesviruses should be taken into account when treating patients with APS-1.", "doi": "10.1016/j.clim.2021.108851", "pmid": "34508889", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1521-6616(21)00188-1"}], "notes": [], "created": "2021-09-13T06:29:34.119Z", "modified": "2021-09-13T06:29:34.132Z"}, {"entity": "publication", "iuid": "7417890877ab4f709614ce6eae82f5ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7417890877ab4f709614ce6eae82f5ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7417890877ab4f709614ce6eae82f5ef"}}, "title": "Autoimmunity roots of the thrombotic events after COVID-19 vaccination.", "authors": [{"family": "Elrashdy", "given": "Fatma", "initials": "F"}, {"family": "Tambuwala", "given": "Murtaza M", "initials": "MM"}, {"family": "Hassan", "given": "Sk Sarif", "initials": "SS"}, {"family": "Adadi", "given": "Parise", "initials": "P"}, {"family": "Seyran", "given": "Murat", "initials": "M"}, {"family": "El-Aziz", "given": "Tarek Mohamed Abd", "initials": "TMA"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Lal", "given": "Amos", "initials": "A"}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA"}, {"family": "Kandimalla", "given": "Ramesh", "initials": "R"}, {"family": "Bazan", "given": "Nicolas G", "initials": "NG"}, {"family": "Azad", "given": "Gajendra Kumar", "initials": "GK"}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Choudhury", "given": "Pabitra Pal", "initials": "PP"}, {"family": "Serrano-Aroca", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "Takayama", "given": "Kazuo", "initials": "K"}, {"family": "Chauhan", "given": "Gaurav", "initials": "G"}, {"family": "Pizzol", "given": "Damiano", "initials": "D"}, {"family": "Barh", "given": "Debmalya", "initials": "D"}, {"family": "Panda", "given": "Pritam Kumar", "initials": "PK"}, {"family": "Mishra", "given": "Yogendra K", "initials": "YK"}, {"family": "Pal\u00f9", "given": "Giorgio", "initials": "G"}, {"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Redwan", "given": "Elrashdy M", "initials": "EM"}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN"}], "type": "journal article", "published": "2021-09-08", "journal": {"title": "Autoimmun Rev", "issn": "1873-0183", "pages": "102941", "issn-l": null}, "abstract": "Although vaccination represents the most promising way to stop or contain the coronavirus disease 2019 (COVID-19) pandemic and safety and effectiveness of available vaccines were proven, a small number of individuals who received anti-SARS-CoV-2 vaccines developed a prothrombotic syndrome. Vaccine-induced immune thrombotic thrombocytopenia (VITT) can be triggered by the adenoviral vector-based vaccine, whereas lipid nanoparticle-mRNA-based vaccines can induce rare cases of deep vein thrombosis (DVT). Although the main pathogenic mechanisms behind this rare phenomenon have not yet been identified, both host and vaccine factors might be involved, with pathology at least in part being related to the vaccine-triggered autoimmune reaction. In this review, we are considering some aspects related to pathogenesis, major risk factors, as well as peculiarities of diagnosis and treatment of this rare condition.", "doi": "10.1016/j.autrev.2021.102941", "pmid": "34508917", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1568-9972(21)00216-0"}], "notes": [], "created": "2021-09-13T06:30:25.627Z", "modified": "2021-09-13T06:30:25.638Z"}, {"entity": "publication", "iuid": "93fcb469798a40c48b23d8aeebf129d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/93fcb469798a40c48b23d8aeebf129d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/93fcb469798a40c48b23d8aeebf129d5"}}, "title": "Repeated Covid-19 Infection Exists: A Case Series From Pakistan.", "authors": [{"family": "Haq", "given": "Zia Ul", "initials": "ZU"}, {"family": "Fazid", "given": "Sheraz", "initials": "S"}, {"family": "Yousafzai", "given": "Yasar Mehmood", "initials": "YM"}, {"family": "Noor", "given": "Mohammad", "initials": "M"}, {"family": "Ibrahimzai", "given": "Arsalan Khan", "initials": "AK"}, {"family": "Iqbal", "given": "Arif", "initials": "A"}, {"family": "Ullah", "given": "Naeem", "initials": "N"}, {"family": "Sherin", "given": "Akhtar", "initials": "A"}], "type": "journal article", "published": "2021-09-07", "journal": {"title": "J Ayub Med Coll Abbottabad", "issn": "1819-2718", "volume": "33", "issue": "3", "pages": "519-522", "issn-l": null}, "abstract": "Protection against SARS-CoV-2 in infected individuals of COVID-19 is lacking. We report a case series of repeated infections of SARS-CoV-2.\n\nA total of 12 patients were identified with repeated infections for SARS-CoV-2 from 25 April 2020 to 16 March 2021 from Pakistan. Repeated infection was defined as diagnosis of the SARS-CoV-2 with real-time reverse transcriptase-polymerase chain reaction (RT-PCR) tests in the first and second phase of infection after complete recovery from the first phase of infection with a negative RT-PCR.\n\nOf the 12 participants, 75% (n=9) were male and mean age of the participants were 40.1\u00b19.7 years. Mean duration between the first and second phase of infection was 184\u00b168.9 days. Patients presenting with mild infection in the first phase largely developed moderate to severe infection in the second phase. None of them were vaccinated.\n\nThe pandemic of COVID-19 is on the rise and repeated infection from SARS-CoV-2 is occurring.", "doi": null, "pmid": "34487669", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "9558/3124"}], "notes": [], "created": "2021-09-09T05:34:50.367Z", "modified": "2021-09-09T05:34:50.391Z"}, {"entity": "publication", "iuid": "94460c8969544292a92f17229253e3f5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/94460c8969544292a92f17229253e3f5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/94460c8969544292a92f17229253e3f5"}}, "title": "Author Response: CSF Biomarkers in Patients With COVID-19 and Neurologic Symptoms: A Case Series.", "authors": [{"family": "Ed\u00e9n", "given": "Arvid", "initials": "A"}], "type": "journal article", "published": "2021-09-07", "journal": {"title": "Neurology", "issn": "1526-632X", "volume": "97", "issue": "10", "pages": "510", "issn-l": "0028-3878"}, "abstract": null, "doi": "10.1212/WNL.0000000000012530", "pmid": "34489344", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "97/10/510"}], "notes": [], "created": "2021-09-09T05:35:27.340Z", "modified": "2023-06-19T14:45:47.724Z"}, {"entity": "publication", "iuid": "467597e93a374a49a004b6609177e767", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/467597e93a374a49a004b6609177e767.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/467597e93a374a49a004b6609177e767"}}, "title": "Update of the European Society for Vascular Surgery (ESVS) 2020 Clinical Practice Guidelines on the Management of Acute Limb Ischaemia in Light of the COVID-19 Pandemic, Based on a Scoping Review of the Literature.", "authors": [{"family": "Jongkind", "given": "Vincent", "initials": "V"}, {"family": "Earnshaw", "given": "Jonothan J", "initials": "JJ"}, {"family": "Bastos Gon\u00e7alves", "given": "Frederico", "initials": "F"}, {"family": "Cochennec", "given": "Frederic", "initials": "F"}, {"family": "Debus", "given": "E Sebastian", "initials": "ES"}, {"family": "Hinchliffe", "given": "Robert", "initials": "R"}, {"family": "Menyhei", "given": "Gabor", "initials": "G"}, {"family": "Svetlikov", "given": "Alexei V", "initials": "AV"}, {"family": "Tshomba", "given": "Yamume", "initials": "Y"}, {"family": "Van Den Berg", "given": "Jos C", "initials": "JC"}, {"family": "Bj\u00f6rck", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2021-09-06", "journal": {"title": "Eur J Vasc Endovasc Surg", "issn": "1532-2165", "issn-l": "1078-5884"}, "abstract": "To perform a scoping review of how patients with COVID-19 are affected by acute limb ischaemia (ALI) and evaluate the recommendations of the 2020 ESVS ALI Guidelines for these patients.\n\nResearch questions were defined, and a systematic literature search was performed following the PRISMA guidelines. Abstracts and unpublished literature were not included. The definition of ALI in this review is in accordance with the ESVS guidelines.\n\nMost identified papers were case reports or case series, although population based data and data from randomised controlled trials were also identified. In total, 114 unique and relevant papers were retrieved. Data were conflicting concerning whether the incidence of ALI increased, or remained unchanged, during the pandemic. Case reports and series reported ALI in patients who were younger and healthier than usual, with a greater proportion affecting the upper limb. Whether or not this is coincidental remains uncertain. The proportion of men/women affected seems unchanged. Most reported cases were in hospitalised patients with severe COVID-19. Patients with ALI as their first manifestation of COVID-19 were reported. Patients with ALI have a worse outcome if they have a simultaneous COVID-19 infection. High levels of D-dimer may predict the occurrence of arterial thromboembolic events in patients with COVID-19. Heparin resistance was observed. Anticoagulation should be given to hospitalised COVID-19 patients in prophylactic dosage. Most of the treatment recommendations from the ESVS Guidelines remained relevant, but the following were modified regarding patients with COVID-19 and ALI: 1) CTA imaging before revascularisation should include the entire aorta and iliac arteries; 2) there should be a high index of suspicion, early testing for COVID-19 infection and protective measures are advised; and 3) there should be preferential use of local or locoregional anaesthesia during revascularisation.\n\nAlthough the epidemiology of ALI has changed during the pandemic, the recommendations of the ESVS ALI Guidelines remain valid. The above mentioned minor modifications should be considered in patients with COVID-19 and ALI.", "doi": "10.1016/j.ejvs.2021.08.028", "pmid": "34686452", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1078-5884(21)00688-2"}, {"db": "pmc", "key": "PMC8418912"}], "notes": [], "created": "2021-10-26T18:17:23.347Z", "modified": "2021-10-26T18:17:23.360Z"}, {"entity": "publication", "iuid": "b4c697717ef34758b986290c183cf508", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b4c697717ef34758b986290c183cf508.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b4c697717ef34758b986290c183cf508"}}, "title": "The Impact of the COVID-19 Pandemic and Societal Infection Control Measures on Children and Adolescents' Mental Health: A Scoping Review.", "authors": [{"family": "Marchi", "given": "Jamile", "initials": "J"}, {"family": "Johansson", "given": "Nina", "initials": "N"}, {"family": "Sarkadi", "given": "Anna", "initials": "A"}, {"family": "Warner", "given": "Georgina", "initials": "G"}], "type": "journal article", "published": "2021-09-06", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "711791", "issn-l": "1664-0640"}, "abstract": "Background: The COVID-19 pandemic is primarily a crisis that affects people's physical health. However, it is well-known from previous epidemics and pandemics that there are other indirect negative impacts on mental health, among others. The purpose of this scoping review was to explore and summarise primary empirical research evidence on how the COVID-19 pandemic and societal infection control measures have impacted children and adolescents' mental health. Methods: A literature search was conducted in five scientific databases: PubMed, APA PsycINFO, Web of Science, CINHAL, and Social Science Premium Collection. The search string was designed using the Population (0-18 years), Exposure (COVID-19), Outcomes (mental health) framework. Mental health was defined broadly, covering mental well-being to mental disorders and psychiatric conditions. Results: Fifty-nine studies were included in the scoping review. Of these, 44 were cross-sectional and 15 were longitudinal studies. Most studies reported negative impact of the COVID-19 pandemic on child and adolescent mental health outcomes, yet the evidence was mixed. This was also the case for studies investigating societal control measures. Strong resilience, positive emotion regulation, physical activity, parental self-efficacy, family functioning and emotional regulation, and social support were reported as protective factors. On the contrary, emotional reactivity and experiential avoidance, exposure to excessive information, COVID-19 school concerns, presence of COVID-19 cases in the community, parental mental health problems, and high internet, social media and video game use were all identified as potentially harmful factors. Conclusions: Due to the methodological heterogeneity of the studies and geographical variation, it is challenging to draw definitive conclusions about the real impact of the COVID-19 pandemic on the mental health of children and adolescents. However, the existing body of research gives some insight to how parents, clinicians and policy makers can take action to mitigate the effects of COVID-19 and control measures. Interventions to promote physical activity and reduce screen time among children and adolescents are recommended, as well as parenting support programs.", "doi": "10.3389/fpsyt.2021.711791", "pmid": "34552516", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8451953"}], "notes": [], "created": "2021-10-27T05:16:37.510Z", "modified": "2021-10-27T05:17:05.092Z"}, {"entity": "publication", "iuid": "1c19c7f89b64441aa4a486609ca8c13f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1c19c7f89b64441aa4a486609ca8c13f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1c19c7f89b64441aa4a486609ca8c13f"}}, "title": "Storying COVID-19: fear, digitalisation, and the transformational potential of storytelling.", "authors": [{"family": "Essebo", "given": "Maja", "initials": "M", "orcid": "0000-0002-7173-2108", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b062eec25a734c4a87676eae288b5926.json"}}], "type": "journal article", "published": "2021-09-06", "journal": {"title": "Sustain Sci", "issn": "1862-4057", "pages": "1-10", "issn-l": null}, "abstract": "Stories are being increasingly recognised for their potential as creators, not only depicters, of change. As such, they are receiving greater interest within sustainability science, not least in the approaches specifically focused on transformative processes of co-creation. But while highly powerful, stories are confined by both inherent and external frameworks that, if not acknowledged, limit their transformative potential. This paper addresses two such critical issues-fear and digitalisation-and discusses the ways in which they influence how and with what effects stories can be told. It uses the COVID-19 pandemic as illustration of storytelling processes and outlines some of the ways in which we can, and cannot, draw parallels between pandemic and climate change storytelling.", "doi": "10.1007/s11625-021-01031-9", "pmid": "34512803", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "1031"}, {"db": "pmc", "key": "PMC8420142"}], "notes": [], "created": "2021-09-20T06:33:49.077Z", "modified": "2021-09-20T06:33:49.136Z"}, {"entity": "publication", "iuid": "2dea08cfe69143f3ab0f641cdcccf415", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2dea08cfe69143f3ab0f641cdcccf415.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2dea08cfe69143f3ab0f641cdcccf415"}}, "title": "Older Persons and the Right to Health in the Nordics during COVID-19.", "authors": [{"family": "\u00d3 Cathaoir", "given": "Katharina", "initials": "K", "orcid": "0000-0002-1535-9134", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0f0c704b3d146a8963031546ad087e9.json"}}, {"family": "Aasen", "given": "Henriette Sinding", "initials": "HS", "orcid": "0000-0002-4122-0902", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df3b82f21dc845749a0c800953237ce9.json"}}, {"family": "Gunnarsd\u00f3ttir", "given": "Hrefna D", "initials": "HD", "orcid": "0000-0001-7276-1587", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3cd2a452745b40c0bb99785a50af9ce1.json"}}, {"family": "Kimmel", "given": "Kaisa-Maria", "initials": "KM", "orcid": "0000-0003-4088-4616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/66cbcab717a94e6aa181fee91897f9cb.json"}}, {"family": "Lohiniva-Kerkel\u00e4", "given": "Mirva", "initials": "M"}, {"family": "Rognlien", "given": "Ida Gundersby", "initials": "IG", "orcid": "0000-0001-8065-6138", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ef852cd476e470ca1805358be2b8a70.json"}}, {"family": "Westerh\u00e4ll", "given": "Lotta Vahlne", "initials": "LV", "orcid": "0000-0002-5031-6236", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8fbf37e787e471988ffb05e9cf48b2f.json"}}], "type": "journal article", "published": "2021-09-06", "journal": {"title": "Eur J Health Law", "issn": "1571-8093", "issn-l": null, "volume": null, "issue": null, "pages": "1-28"}, "abstract": "We reflect on the extent to which Nordic countries have safeguarded the right to health of older persons during the pandemic in 2020. All Nordic states have ratified the International Covenant on Economic, Social and Cultural Rights and thereby committed to recognising the right to health. We use the AAAQ framework developed by the Committee on Economic, Social and Cultural Rights to draw attention to aspects of the respective states' responses. The COVID-19 pandemic has had significant impacts on the health of older persons, from the direct effects of the virus, such as illness and death, to indirect impacts, like isolation and loneliness. We find that Nordic states have at times failed to prioritise the full realisation of the core obligations of the right to health for older persons, namely, non-discrimination and provision of essential healthcare. Resource constraints cannot justify discrimination or failure to respect autonomy, integrity and human dignity.", "doi": "10.1163/15718093-bja10052", "pmid": "34610576", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:28:54.132Z", "modified": "2023-06-19T14:59:44.378Z"}, {"entity": "publication", "iuid": "cd377664d20c4cce90850186a7870427", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd377664d20c4cce90850186a7870427.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd377664d20c4cce90850186a7870427"}}, "title": "Diet quality and risk and severity of COVID-19: a prospective cohort study.", "authors": [{"family": "Merino", "given": "Jordi", "initials": "J", "orcid": "0000-0001-8312-1438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12ab049914a542b39affcfb4196861d2.json"}}, {"family": "Joshi", "given": "Amit D", "initials": "AD", "orcid": "0000-0001-7581-6934", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd29dfe6b8c742c894ca26d217080079.json"}}, {"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Leeming", "given": "Emily R", "initials": "ER", "orcid": "0000-0002-0531-4901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59a9e4a4912f451c861668efdd226c44.json"}}, {"family": "Mazidi", "given": "Mohsen", "initials": "M"}, {"family": "Drew", "given": "David A", "initials": "DA", "orcid": "0000-0002-8813-0816", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd3a2cffdc104f18b8684cf4f27d68b2.json"}}, {"family": "Gibson", "given": "Rachel", "initials": "R"}, {"family": "Graham", "given": "Mark S", "initials": "MS"}, {"family": "Lo", "given": "Chun-Han", "initials": "CH", "orcid": "0000-0001-8202-4513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a0d9111318f4084b64f47b5b56c8c85.json"}}, {"family": "Capdevila", "given": "Joan", "initials": "J"}, {"family": "Murray", "given": "Benjamin", "initials": "B"}, {"family": "Hu", "given": "Christina", "initials": "C"}, {"family": "Selvachandran", "given": "Somesh", "initials": "S"}, {"family": "Hammers", "given": "Alexander", "initials": "A"}, {"family": "Bhupathiraju", "given": "Shilpa N", "initials": "SN"}, {"family": "Sharma", "given": "Shreela V", "initials": "SV"}, {"family": "Sudre", "given": "Carole", "initials": "C"}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Chavarro", "given": "Jorge E", "initials": "JE"}, {"family": "Kwon", "given": "Sohee", "initials": "S"}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874802ae65824a90ba50eabdeabb8356.json"}}, {"family": "Willett", "given": "Walter C", "initials": "WC"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Spector", "given": "Timothy D", "initials": "TD"}, {"family": "Berry", "given": "Sarah", "initials": "S"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}], "type": "journal article", "published": "2021-09-06", "journal": {"title": "Gut", "issn": "1468-3288", "issn-l": null}, "abstract": "Poor metabolic health and unhealthy lifestyle factors have been associated with risk and severity of COVID-19, but data for diet are lacking. We aimed to investigate the association of diet quality with risk and severity of COVID-19 and its interaction with socioeconomic deprivation.\n\nWe used data from 592 571 participants of the smartphone-based COVID-19 Symptom Study. Diet information was collected for the prepandemic period using a short food frequency questionnaire, and diet quality was assessed using a healthful Plant-Based Diet Score, which emphasises healthy plant foods such as fruits or vegetables. Multivariable Cox models were fitted to calculate HRs and 95% CIs for COVID-19 risk and severity defined using a validated symptom-based algorithm or hospitalisation with oxygen support, respectively.\n\nOver 3 886 274 person-months of follow-up, 31 815 COVID-19 cases were documented. Compared with individuals in the lowest quartile of the diet score, high diet quality was associated with lower risk of COVID-19 (HR 0.91; 95% CI 0.88 to 0.94) and severe COVID-19 (HR 0.59; 95% CI 0.47 to 0.74). The joint association of low diet quality and increased deprivation on COVID-19 risk was higher than the sum of the risk associated with each factor alone (Pinteraction=0.005). The corresponding absolute excess rate per 10 000 person/months for lowest vs highest quartile of diet score was 22.5 (95% CI 18.8 to 26.3) among persons living in areas with low deprivation and 40.8 (95% CI 31.7 to 49.8) among persons living in areas with high deprivation.\n\nA diet characterised by healthy plant-based foods was associated with lower risk and severity of COVID-19. This association may be particularly evident among individuals living in areas with higher socioeconomic deprivation.", "doi": "10.1136/gutjnl-2021-325353", "pmid": "34489306", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "gutjnl-2021-325353"}], "notes": [], "created": "2021-09-09T05:35:10.324Z", "modified": "2021-09-09T05:35:10.430Z"}, {"entity": "publication", "iuid": "2f9299a3575e47c8a8e24ac9d6b3861a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2f9299a3575e47c8a8e24ac9d6b3861a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2f9299a3575e47c8a8e24ac9d6b3861a"}}, "title": "Innovative software systems for managing the impact of the COVID-19 pandemic.", "authors": [{"family": "Gill", "given": "Sukhpal Singh", "initials": "SS", "orcid": "0000-0002-3913-0369", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a5ab1ac135540acbd401a52536dd989.json"}}, {"family": "Vinuesa", "given": "Ricardo", "initials": "R", "orcid": "0000-0001-6570-5499", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/145cde54ca084cc6875f33fd7219cfc0.json"}}, {"family": "Balasubramanian", "given": "Venki", "initials": "V", "orcid": "0000-0001-6686-4424", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/876332738b834ed68f85594fe8516d8e.json"}}, {"family": "Ghosh", "given": "Soumya K", "initials": "SK", "orcid": "0000-0001-8359-581X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64a1a896d36a496ba60198a898d55a5d.json"}}], "type": "editorial", "published": "2021-09-05", "journal": {"title": "Softw Pract Exp", "issn": "0038-0644", "issn-l": null}, "abstract": null, "doi": "10.1002/spe.3023", "pmid": "34908601", "labels": {"Type: Other": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "SPE3023"}, {"db": "pmc", "key": "PMC8662097"}], "notes": [], "created": "2021-12-18T17:51:25.701Z", "modified": "2021-12-18T17:51:25.862Z"}, {"entity": "publication", "iuid": "351098c9c8274fe6ae586872001b4b7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/351098c9c8274fe6ae586872001b4b7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/351098c9c8274fe6ae586872001b4b7a"}}, "title": "DNA methylome-based validation of induced sputum as an effective protocol to study lung immunity: construction of a classifier of pulmonary cell types.", "authors": [{"family": "Das", "given": "Jyotirmoy", "initials": "J", "orcid": "0000-0002-5649-4658", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/883ec5a66e47458fa303f9df2572f669.json"}}, {"family": "Idh", "given": "Nina", "initials": "N"}, {"family": "Sikkeland", "given": "Liv Ingunn Bjoner", "initials": "LIB"}, {"family": "Paues", "given": "Jakob", "initials": "J"}, {"family": "Lerm", "given": "Maria", "initials": "M", "orcid": "0000-0002-5092-9892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a326e1fb7efa4c4f8f59e7572f6b83bc.json"}}], "type": "journal article", "published": "2021-09-05", "journal": {"title": "Epigenetics", "issn": "1559-2308", "pages": "1-12", "issn-l": null}, "abstract": "Flow cytometry is a classical approach used to define cell types in peripheral blood. While DNA methylation signatures have been extensively employed in recent years as an alternative to flow cytometry to define cell populations in peripheral blood, this approach has not been tested in lung-derived samples. Here, we compared bronchoalveolar lavage with a more cost-effective and less invasive technique based on sputum induction and developed a DNA methylome-based algorithm that can be used to deconvolute the cell types in such samples. We analysed the DNA methylome profiles of alveolar macrophages and lymphocytes cells isolated from the pulmonary compartment. The cells were isolated using two different methods, sputum induction and bronchoalveolar lavage. A strong positive correlation between the DNA methylome profiles of cells obtained with the two isolation methods was found. We observed the best correlation of the DNA methylomes when both isolation methods captured cells from the lower parts of the lungs. We also identified unique patterns of CpG methylation in DNA obtained from the two cell populations, which can be used as a signature to discriminate between the alveolar macrophages and lymphocytes by means of open-source algorithms. We validated our findings with external data and obtained results consistent with the previous findings. Our analysis opens up a new possibility to identify different cell populations from lung samples and promotes sputum induction as a tool to study immune cell populations from the lung.", "doi": "10.1080/15592294.2021.1969499", "pmid": "34482796", "labels": {"Funder: Hj\u00e4rt-Lungfonden": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://github.com/JD2112/AlveolarCellTypeDeconvolution", "description": "R scripts to analyze the Alveolar macrophages (HLA-DR+/CD3-) and lymphocytes (CD3+) specific cell types from DNA methylation analysis"}], "notes": [], "created": "2021-11-18T13:11:18.641Z", "modified": "2021-11-18T13:16:03.696Z"}, {"entity": "publication", "iuid": "e63ca637474a43d4b0632bdaa2cc9a0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e63ca637474a43d4b0632bdaa2cc9a0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e63ca637474a43d4b0632bdaa2cc9a0e"}}, "title": "The Impact of the COVID-19 Pandemic on Students' Mental Health and Sleep in Saudi Arabia.", "authors": [{"family": "Alyoubi", "given": "Azizah", "initials": "A"}, {"family": "Halstead", "given": "Elizabeth J", "initials": "EJ", "orcid": "0000-0002-5633-1859", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/139cecf838f041729fc9fa6e6a5bf725.json"}}, {"family": "Zambelli", "given": "Zoe", "initials": "Z"}, {"family": "Dimitriou", "given": "Dagmara", "initials": "D", "orcid": "0000-0002-6856-0595", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5de719ff390b404e8a7328a590ee500d.json"}}], "type": "journal article", "published": "2021-09-04", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "17", "pages": null}, "abstract": "Mental health problems are prevalent among university students in Saudi Arabia. This study aimed to investigate the impact of the COVID-19 pandemic on university students' mental health and sleep in Saudi Arabia.\r\n\r\nA total of 582 undergraduate students from Saudi Arabia aged between 18 and 45 years old (M = 20.91, SD = 3.17) completed a cross-sectional online questionnaire measuring depression, anxiety, stress, resilience, and insomnia during the COVID-19 pandemic (2020). Analysis included an independent samples t-test, one-way ANOVA, and Hierarchical regression analysis.\r\n\r\nUndergraduate students reported high levels of depression, anxiety, and perceived stress and low levels of resilience (p < 0.001) during the pandemic. In addition, students reported experiencing insomnia. A hierarchical regression analysis indicated that lower resilience, high levels of insomnia, having a pre-existing mental health condition, and learning difficulties (such as dyslexia, dyspraxia, or dyscalculia) were significantly associated with high levels of depression and stress. In addition, lower resilience, a high level of insomnia, and pre-existing mental health conditions were significantly associated with high levels of anxiety. Finally, a lower level of psychological resilience and a high level of insomnia were significantly associated with increased levels of depression, anxiety and stress within university students.\r\n\r\nThis study has provided evidence that a lower level of psychological resilience and insomnia were associated with mental health problems among undergraduate students in Saudi Arabia, thus enhancing psychological resilience and interventions to support sleep and mental health are vital to support student well-being outcomes throughout the pandemic.", "doi": "10.3390/ijerph18179344", "pmid": "34501935", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph18179344"}], "notes": [], "created": "2021-09-13T06:25:17.108Z", "modified": "2021-11-18T14:11:36.793Z"}, {"entity": "publication", "iuid": "371aa054a56c4cccace10eb7bfd8e9f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/371aa054a56c4cccace10eb7bfd8e9f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/371aa054a56c4cccace10eb7bfd8e9f2"}}, "title": "The Rapid Implementation of a Psychological Support Model for Frontline Healthcare Workers During the COVID-19 Pandemic: A Case Study and Process Evaluation.", "authors": [{"family": "Appelbom", "given": "Sophia", "initials": "S"}, {"family": "Bujacz", "given": "Aleksandra", "initials": "A"}, {"family": "Finnes", "given": "Anna", "initials": "A"}, {"family": "Ahlbeck", "given": "Karsten", "initials": "K"}, {"family": "Bromberg", "given": "Filip", "initials": "F"}, {"family": "Holmberg", "given": "Johan", "initials": "J"}, {"family": "Larsson", "given": "Liv", "initials": "L"}, {"family": "Olgren", "given": "Birgitta", "initials": "B"}, {"family": "Wanecek", "given": "Michael", "initials": "M"}, {"family": "Wetterborg", "given": "Dan", "initials": "D"}, {"family": "Wicksell", "given": "Rikard", "initials": "R"}], "type": "journal article", "published": "2021-09-03", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "713251", "issn-l": "1664-0640"}, "abstract": "The COVID-19 pandemic highlighted the need for psychological support initiatives directed toward frontline healthcare workers, which can be rapidly and sustainably implemented during an infectious disease outbreak. The current case study presents a comprehensive model of psychological support that was implemented at an intensive care unit (ICU) during the first wave of the COVID-19 pandemic. The psychological support model aimed at promoting a resilient stress reaction among frontline staff by protecting physical, social, and psychological resources. The initiatives, targeting different groups of workers, included education and training, peer support, psychologist-supervised and unsupervised group sessions, on-boarding for transferred staff, manager support, and individual sessions for workers experiencing strong stress reactions. The results of the process evaluation of this rapid implementation suggest that peer support initiatives as well as daily group sessions were the most appreciated forms of psychological support. Psychologists involved in organizing and providing the support highlighted several aspects of a successful implementation of the support model: offering support during work hours (preferably after shift), positive attitude of line managers that framed support initiatives as a team effort, and involvement of experienced psychologists able to quickly adjust the content of the support according to the current needs. The study also identified two main problems of the current implementation: the lack of efficient planning due to the use of volunteer work and the need for more structural resources on the organizational level to ensure long-term sustainability of the support model and its implementation among all groups of healthcare staff. The current case study highlights the importance of establishing permanent structural resources and routines for psychological support integrated in clinical practice by healthcare organizations to improve both rapid and sustainable response to future crises.", "doi": "10.3389/fpsyt.2021.713251", "pmid": "34539465", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8446385"}], "notes": [], "created": "2021-09-23T05:19:09.231Z", "modified": "2021-10-10T15:35:07.711Z"}, {"entity": "publication", "iuid": "6ad5487667444cb69faecd064e442597", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ad5487667444cb69faecd064e442597.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ad5487667444cb69faecd064e442597"}}, "title": "Fear During COVID-19 pandemic: Fear of COVID-19 Scale Measurement Properties.", "authors": [{"family": "Ullah", "given": "Irfan", "initials": "I", "orcid": "0000-0003-1100-101X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8d5a7e15ae6487cbdda0de3b2a531c3.json"}}, {"family": "Jaguga", "given": "Florence", "initials": "F", "orcid": "0000-0002-8381-6309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1abd85e0b8ec4d64afe50bf337816121.json"}}, {"family": "Ransing", "given": "Ramdas", "initials": "R"}, {"family": "Pereira-Sanchez", "given": "Victor", "initials": "V", "orcid": "0000-0002-2576-1549", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/244ab7530cd544b69173751dd9ca1cc6.json"}}, {"family": "Orsolini", "given": "Laura", "initials": "L", "orcid": "0000-0002-6882-3770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5aa4ac3eb4e44e208810fed3a72275be.json"}}, {"family": "Ori", "given": "Dorottya", "initials": "D", "orcid": "0000-0003-0878-165X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae84a3d4e3f047349ef01305a75cac8a.json"}}, {"family": "de Filippis", "given": "Renato", "initials": "R", "orcid": "0000-0001-6928-1224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d34493cdd004ea7926df58f411980bf.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}, {"family": "Adiukwu", "given": "Frances", "initials": "F", "orcid": "0000-0001-5543-1746", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41005a01477f44f995d839aacb60c8c9.json"}}, {"family": "Kilic", "given": "Ozge", "initials": "O", "orcid": "0000-0001-9764-343X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bef5a352062d42b8a18f30db5cd739c9.json"}}, {"family": "Hayatudeen", "given": "Nafisatu", "initials": "N"}, {"family": "Shoib", "given": "Sheikh", "initials": "S", "orcid": "0000-0002-3739-706X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8836f5d9f2a94346b1895a991b2ea5cc.json"}}, {"family": "Ojeahere", "given": "Margaret Isioma", "initials": "MI", "orcid": "0000-0002-0593-2400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/746f8d758e1d4384bca4c0a68d07eed4.json"}}, {"family": "Nagendrappa", "given": "Sachin", "initials": "S", "orcid": "0000-0002-8682-2982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d10848bc08245fc8668221fd48d5806.json"}}, {"family": "Handuleh", "given": "Jibril I M", "initials": "JIM", "orcid": "0000-0003-2662-1078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/266f47402be1449b8875f528d9f27e62.json"}}, {"family": "Dashi", "given": "Elona", "initials": "E", "orcid": "0000-0002-9280-2734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df7ff12c423f471287b289ccdba40fdb.json"}}, {"family": "Musami", "given": "Umar Baba", "initials": "UB", "orcid": "0000-0003-3540-4120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dcb21581a7ae43db9a449a79230a1d5b.json"}}, {"family": "Vahdani", "given": "Bita", "initials": "B", "orcid": "0000-0002-5727-8359", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a744c856d694c7c8c1a49396989a856.json"}}, {"family": "Ashrafi", "given": "Agaah", "initials": "A", "orcid": "0000-0003-1145-8001", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00434a52d4234c02871215b9c2c34feb.json"}}, {"family": "Jatchavala", "given": "Chonnakarn", "initials": "C", "orcid": "0000-0001-9765-2184", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2450b1839b534304859eeab927f8f138.json"}}, {"family": "Abbass", "given": "Zargham", "initials": "Z", "orcid": "0000-0002-5288-1079", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb121e28aa4b4c0ea21ba294f60773c4.json"}}, {"family": "El Halabi", "given": "Sarah", "initials": "S"}, {"family": "Ogunnubi", "given": "Oluseun Peter", "initials": "OP", "orcid": "0000-0001-9997-3379", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/17ebbf90d8fd48f9bc69a85d022929ea.json"}}, {"family": "Pinto da Costa", "given": "Mariana", "initials": "M"}, {"family": "Ramalho", "given": "Rodrigo", "initials": "R", "orcid": "0000-0002-2372-6854", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b990d3c278047a9b3878d47316ea4ed.json"}}], "type": "journal article", "published": "2021-09-03", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "issn-l": null, "volume": null, "issue": null, "pages": "1-10"}, "abstract": null, "doi": "10.1007/s11469-021-00528-9", "pmid": "34512215", "labels": {"Category: Public Health": null, "Type: Other": null}, "xrefs": [{"db": "pii", "key": "528"}, {"db": "pmc", "key": "PMC8415186"}], "notes": [], "created": "2021-09-20T06:35:03.095Z", "modified": "2021-11-18T14:11:04.137Z"}, {"entity": "publication", "iuid": "7144f9cd2f3f4eb782a60af0a795a9b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7144f9cd2f3f4eb782a60af0a795a9b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7144f9cd2f3f4eb782a60af0a795a9b2"}}, "title": "Autoimmune hepatitis triggered by COVID-19: A report of two cases.", "authors": [{"family": "Kaba\u00e7am", "given": "G\u00f6khan", "initials": "G"}, {"family": "Wahlin", "given": "Staffan", "initials": "S"}, {"family": "Efe", "given": "Cumali", "initials": "C", "orcid": "0000-0001-6593-5702", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cd621ab96e04e678b0188c48d54b90a.json"}}], "type": "letter", "published": "2021-09-03", "journal": {"title": "Liver Int", "issn": "1478-3231", "issn-l": null}, "abstract": null, "doi": "10.1111/liv.15044", "pmid": "34478591", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-09-06T05:53:14.195Z", "modified": "2021-09-06T05:53:14.253Z"}, {"entity": "publication", "iuid": "e4b92774ea2c47e1b13c32effc754650", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e4b92774ea2c47e1b13c32effc754650.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e4b92774ea2c47e1b13c32effc754650"}}, "title": "Assessing the capacity of symptom scores to predict COVID-19 positivity in Nigeria: a national derivation and validation cohort study.", "authors": [{"family": "Elimian", "given": "Kelly Osezele", "initials": "KO", "orcid": "0000-0003-2729-1613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/695dddf720414c3585d35b30184f0178.json"}}, {"family": "Aderinola", "given": "Olaolu", "initials": "O"}, {"family": "Gibson", "given": "Jack", "initials": "J"}, {"family": "Myles", "given": "Puja", "initials": "P"}, {"family": "Ochu", "given": "Chinwe Lucia", "initials": "CL", "orcid": "0000-0002-0630-7332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f390fa99a654ff899f5e9df6fbaf88e.json"}}, {"family": "King", "given": "Carina", "initials": "C"}, {"family": "Okwor", "given": "Tochi", "initials": "T"}, {"family": "Gaudenzi", "given": "Giulia", "initials": "G", "orcid": "0000-0003-4923-6965", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ee3937112f5484ab9acb5c54e4fabb4.json"}}, {"family": "Olayinka", "given": "Adebola", "initials": "A"}, {"family": "Zaiyad", "given": "Habib Garba", "initials": "HG"}, {"family": "Ohonsi", "given": "Cornelius", "initials": "C"}, {"family": "Ebhodaghe", "given": "Blessing", "initials": "B"}, {"family": "Dan-Nwafor", "given": "Chioma", "initials": "C"}, {"family": "Nwachukwu", "given": "William", "initials": "W"}, {"family": "Abdus-Salam", "given": "Ismail Adeshina", "initials": "IA"}, {"family": "Akande", "given": "Oluwatosin Wuraola", "initials": "OW", "orcid": "0000-0001-6906-895X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7ce51eb7a0b4a04b6af2802c88e2290.json"}}, {"family": "Falodun", "given": "Olanrewaju", "initials": "O"}, {"family": "Arinze", "given": "Chinedu", "initials": "C"}, {"family": "Ezeokafor", "given": "Chidiebere", "initials": "C"}, {"family": "Jafiya", "given": "Abubakar", "initials": "A"}, {"family": "Ojimba", "given": "Anastacia", "initials": "A"}, {"family": "Aremu", "given": "John Tunde", "initials": "JT"}, {"family": "Joseph", "given": "Emmanuel", "initials": "E"}, {"family": "Bowale", "given": "Abimbola", "initials": "A"}, {"family": "Mutiu", "given": "Bamidele", "initials": "B"}, {"family": "Saka", "given": "Babatunde", "initials": "B"}, {"family": "Jinadu", "given": "Arisekola", "initials": "A"}, {"family": "Hamza", "given": "Khadeejah", "initials": "K"}, {"family": "Ibeh", "given": "Christian", "initials": "C"}, {"family": "Bello", "given": "Shaibu", "initials": "S"}, {"family": "Asuzu", "given": "Michael", "initials": "M"}, {"family": "Mba", "given": "Nwando", "initials": "N"}, {"family": "Oladejo", "given": "John", "initials": "J"}, {"family": "Ilori", "given": "Elsie", "initials": "E"}, {"family": "Alfv\u00e9n", "given": "Tobias", "initials": "T"}, {"family": "Igumbor", "given": "Ehimario", "initials": "E"}, {"family": "Ihekweazu", "given": "Chikwe", "initials": "C"}], "type": "journal article", "published": "2021-09-03", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "9", "pages": "e049699"}, "abstract": "This study aimed to develop and validate a symptom prediction tool for COVID-19 test positivity in Nigeria.\r\n\r\nPredictive modelling study.\r\n\r\nAll Nigeria States and the Federal Capital Territory.\r\n\r\nA cohort of 43 221 individuals within the national COVID-19 surveillance dataset from 27 February to 27 August 2020. Complete dataset was randomly split into two equal halves: derivation and validation datasets. Using the derivation dataset (n=21 477), backward multivariable logistic regression approach was used to identify symptoms positively associated with COVID-19 positivity (by real-time PCR) in children (\u226417 years), adults (18-64 years) and elderly (\u226565 years) patients separately.\r\n\r\nWeighted statistical and clinical scores based on beta regression coefficients and clinicians' judgements, respectively. Using the validation dataset (n=21 744), area under the receiver operating characteristic curve (AUROC) values were used to assess the predictive capacity of individual symptoms, unweighted score and the two weighted scores.\r\n\r\nOverall, 27.6% of children (4415/15 988), 34.6% of adults (9154/26 441) and 40.0% of elderly (317/792) that had been tested were positive for COVID-19. Best individual symptom predictor of COVID-19 positivity was loss of smell in children (AUROC 0.56, 95% CI 0.55 to 0.56), either fever or cough in adults (AUROC 0.57, 95% CI 0.56 to 0.58) and difficulty in breathing in the elderly (AUROC 0.53, 95% CI 0.48 to 0.58) patients. In children, adults and the elderly patients, all scoring approaches showed similar predictive performance.\r\n\r\nThe predictive capacity of various symptom scores for COVID-19 positivity was poor overall. However, the findings could serve as an advocacy tool for more investments in resources for capacity strengthening of molecular testing for COVID-19 in Nigeria.", "doi": "10.1136/bmjopen-2021-049699", "pmid": "34479936", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-049699"}], "notes": [], "created": "2021-09-06T05:52:44.836Z", "modified": "2021-11-18T14:05:33.826Z"}, {"entity": "publication", "iuid": "462683b358b4463eb5acc3d9c705555b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/462683b358b4463eb5acc3d9c705555b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/462683b358b4463eb5acc3d9c705555b"}}, "title": "Separable Microneedle Patch to Protect and Deliver DNA Nanovaccines Against COVID-19.", "authors": [{"family": "Yin", "given": "Yue", "initials": "Y"}, {"family": "Su", "given": "Wen", "initials": "W"}, {"family": "Zhang", "given": "Jie", "initials": "J"}, {"family": "Huang", "given": "Wenping", "initials": "W"}, {"family": "Li", "given": "Xiaoyang", "initials": "X"}, {"family": "Ma", "given": "Haixia", "initials": "H"}, {"family": "Tan", "given": "Mixiao", "initials": "M"}, {"family": "Song", "given": "Haohao", "initials": "H"}, {"family": "Cao", "given": "Guoliang", "initials": "G"}, {"family": "Yu", "given": "Shengji", "initials": "S"}, {"family": "Yu", "given": "Di", "initials": "D"}, {"family": "Jeong", "given": "Ji Hoon", "initials": "JH", "orcid": "0000-0002-4836-3551", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ee9be966af4ebb9451f2a155ce453d.json"}}, {"family": "Zhao", "given": "Xiao", "initials": "X"}, {"family": "Li", "given": "Hui", "initials": "H"}, {"family": "Nie", "given": "Guangjun", "initials": "G", "orcid": "0000-0001-5040-9793", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bcb72746a3f4aa29992a27de22194b8.json"}}, {"family": "Wang", "given": "Hai", "initials": "H", "orcid": "0000-0002-1292-998X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db9fc13e307a43f48ca4bf63121051b1.json"}}], "type": "journal article", "published": "2021-09-02", "journal": {"title": "ACS Nano", "issn": "1936-086X", "issn-l": null}, "abstract": "The successful control of coronavirus disease 2019 (COVID-19) pandemic is not only relying on the development of vaccines, but also depending on the storage, transportation, and administration of vaccines. Ideally, nucleic acid vaccine should be directly delivered to proper immune cells or tissue (such as lymph nodes). However, current developed vaccines are normally treated through intramuscular injection, where immune cells do not normally reside. Meanwhile, current nucleic acid vaccines must be stored in a frozen state that may hinder their application in developing countries. Here, we report a separable microneedle (SMN) patch to deliver polymer encapsulated spike (or nucleocapsid) protein encoding DNA vaccines and immune adjuvant for efficient immunization. Compared with intramuscular injection, SMN patch can deliver nanovaccines into intradermal for inducing potent and durable adaptive immunity. IFN-\u03b3+CD4/8+ and IL-2+CD4/8+ T cells or virus specific IgG are significantly increased after vaccination. Moreover, in vivo results show the SMN patches can be stored at room temperature for at least 30 days without decreases in immune responses. These features of nanovaccines-laden SMN patch are important for developing advanced COVID-19 vaccines with global accessibility.", "doi": "10.1021/acsnano.1c03252", "pmid": "34472328", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-09-06T06:09:51.779Z", "modified": "2021-11-19T10:51:08.506Z"}, {"entity": "publication", "iuid": "78a51e65b378445a8fab820383056a5d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/78a51e65b378445a8fab820383056a5d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/78a51e65b378445a8fab820383056a5d"}}, "title": "Physiological respiratory parameters in pre-hospital patients with suspected COVID-19: A prospective cohort study.", "authors": [{"family": "M\u00e4lberg", "given": "Johan", "initials": "J", "orcid": "0000-0003-4289-8202", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f90af5371ce94f988a9f99a74306ab55.json"}}, {"family": "Hadziosmanovic", "given": "Nermin", "initials": "N"}, {"family": "Smekal", "given": "David", "initials": "D"}], "type": "journal article", "published": "2021-09-02", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "9", "pages": "e0257018", "issn-l": "1932-6203"}, "abstract": "The COVID-19 pandemic has presented emergency medical services (EMS) worldwide with the difficult task of identifying patients with COVID-19 and predicting the severity of their illness. The aim of this study was to investigate whether physiological respiratory parameters in pre-hospital patients with COVID-19 differed from those without COVID-19 and if they could be used to aid EMS personnel in the prediction of illness severity.\n\nPatients with suspected COVID-19 were included by EMS personnel in Uppsala, Sweden. A portable respiratory monitor based on pneumotachography was used to sample the included patient's physiological respiratory parameters. A questionnaire with information about present symptoms and background data was completed. COVID-19 diagnoses and hospital admissions were gathered from the electronic medical record system. The physiological respiratory parameters of patients with and without COVID-19 were then analyzed using descriptive statistical analysis and logistic regression.\n\nBetween May 2020 and January 2021, 95 patients were included, and their physiological respiratory parameters analyzed. Of these patients, 53 had COVID-19. Using adjusted logistic regression, the odds of having COVID-19 increased with respiratory rate (95% CI 1.000-1.118), tidal volume (95% CI 0.996-0.999) and negative inspiratory pressure (95% CI 1.017-1.152). Patients admitted to hospital had higher respiratory rates (p<0.001) and lower tidal volume (p = 0.010) compared to the patients who were not admitted. Using adjusted logistic regression, the odds of hospital admission increased with respiratory rate (95% CI 1.081-1.324), rapid shallow breathing index (95% CI 1.006-1.040) and dead space percentage of tidal volume (95% CI 1.027-1.159).\n\nPatients taking smaller, faster breaths with less pressure had higher odds of having COVID-19 in this study. Smaller, faster breaths and higher dead space percentage also increased the odds of hospital admission. Physiological respiratory parameters could be a useful tool in detecting COVID-19 and predicting hospital admissions, although more research is needed.", "doi": "10.1371/journal.pone.0257018", "pmid": "34473782", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-15446"}, {"db": "pmc", "key": "PMC8412304"}], "notes": [], "created": "2021-09-06T06:07:22.950Z", "modified": "2021-09-06T06:08:45.240Z"}, {"entity": "publication", "iuid": "bf9c58a68f07472384d6c71dcc2dc436", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf9c58a68f07472384d6c71dcc2dc436.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf9c58a68f07472384d6c71dcc2dc436"}}, "title": "Impact of the COVID-19 pandemic on the surveillance, prevention and control of antimicrobial resistance: a global survey.", "authors": [{"family": "Tomczyk", "given": "Sara", "initials": "S", "orcid": "0000-0001-6975-2663", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/547fdb65afe640fbb3f09de07366555b.json"}}, {"family": "Taylor", "given": "Angelina", "initials": "A"}, {"family": "Brown", "given": "Allison", "initials": "A"}, {"family": "de Kraker", "given": "Marlieke E A", "initials": "MEA", "orcid": "0000-0003-0903-8614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0791cb6f63f445a087fbb50ddf70a105.json"}}, {"family": "El-Saed", "given": "Aiman", "initials": "A"}, {"family": "Alshamrani", "given": "Majid", "initials": "M"}, {"family": "Hendriksen", "given": "Rene S", "initials": "RS"}, {"family": "Jacob", "given": "Megan", "initials": "M"}, {"family": "L\u00f6fmark", "given": "Sonja", "initials": "S"}, {"family": "Perovic", "given": "Olga", "initials": "O", "orcid": "0000-0001-5580-4629", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3353252a919e40069dd4b0235c672499.json"}}, {"family": "Shetty", "given": "Nandini", "initials": "N"}, {"family": "Sievert", "given": "Dawn", "initials": "D"}, {"family": "Smith", "given": "Rachel", "initials": "R"}, {"family": "Stelling", "given": "John", "initials": "J"}, {"family": "Thakur", "given": "Siddhartha", "initials": "S"}, {"family": "Vietor", "given": "Ann Christin", "initials": "AC"}, {"family": "Eckmanns", "given": "Tim", "initials": "T"}], "type": "journal article", "published": "2021-09-02", "journal": {"title": "J Antimicrob Chemother", "issn": "1460-2091", "issn-l": null}, "abstract": "The COVID-19 pandemic has had a substantial impact on health systems. The WHO Antimicrobial Resistance (AMR) Surveillance and Quality Assessment Collaborating Centres Network conducted a survey to assess the effects of COVID-19 on AMR surveillance, prevention and control.\n\nFrom October to December 2020, WHO Global Antimicrobial Resistance and Use Surveillance System (GLASS) national focal points completed a questionnaire, including Likert scales and open-ended questions. Data were descriptively analysed, income/regional differences were assessed and free-text questions were thematically analysed.\n\nSeventy-three countries across income levels participated. During the COVID-19 pandemic, 67% reported limited ability to work with AMR partnerships; decreases in funding were frequently reported by low- and middle-income countries (LMICs; P < 0.01). Reduced availability of nursing, medical and public health staff for AMR was reported by 71%, 69% and 64%, respectively, whereas 67% reported stable cleaning staff availability. The majority (58%) reported reduced reagents/consumables, particularly LMICs (P < 0.01). Decreased numbers of cultures, elective procedures, chronically ill admissions and outpatients and increased ICU admissions reported could bias AMR data. Reported overall infection prevention and control (IPC) improvement could decrease AMR rates, whereas increases in selected inappropriate IPC practices and antimicrobial prescribing could increase rates. Most did not yet have complete data on changing AMR rates due to COVID-19.\n\nThis was the first survey to explore the global impact of COVID-19 on AMR among GLASS countries. Responses highlight important actions to help ensure that AMR remains a global health priority, including engaging with GLASS to facilitate reliable AMR surveillance data, seizing the opportunity to develop more sustainable IPC programmes, promoting integrated antibiotic stewardship guidance, leveraging increased laboratory capabilities and other system-strengthening efforts.", "doi": "10.1093/jac/dkab300", "pmid": "34473285", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6362680"}], "notes": [], "created": "2021-09-06T06:09:23.666Z", "modified": "2021-09-06T06:09:23.763Z"}, {"entity": "publication", "iuid": "f83279fbc63c4980b12915cb5d036bc9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f83279fbc63c4980b12915cb5d036bc9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f83279fbc63c4980b12915cb5d036bc9"}}, "title": "Challenges in Preventive Practices and Risk Communication towards COVID-19: A Cross-Sectional Study in Bangladesh.", "authors": [{"family": "Rahman", "given": "Farah Naz", "initials": "FN", "orcid": "0000-0002-2265-2742", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35a313c259ed4fe3831ae74c581ee93e.json"}}, {"family": "Bhuiyan", "given": "Md Al Amin", "initials": "MAA", "orcid": "0000-0001-7385-0864", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af9df494efd648649fac724cf777d7d0.json"}}, {"family": "Hossen", "given": "Kabir", "initials": "K"}, {"family": "Khan", "given": "Hafiz T A", "initials": "HTA", "orcid": "0000-0002-1817-3730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b05ad34abbf241f0aa9d7cc4cf0010ac.json"}}, {"family": "Rahman", "given": "Akm Fazlur", "initials": "AF"}, {"family": "Dalal", "given": "Koustuv", "initials": "K", "orcid": "0000-0001-7393-796X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab5e44a17b7545988cb46cdf5b1f3e4e.json"}}], "type": "journal article", "published": "2021-09-02", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "17", "pages": null}, "abstract": "Bangladesh recently experienced a COVID-19 second wave, resulting in the highest number of new cases and deaths in a single day. This study aims to identify the challenges for COVID-19 preventive practices and risk communications and associated factors among Bangladeshi adults. A cross-sectional survey was conducted between December 2020 and January 2021 involving 1382 Bangladeshi adults (aged \u2265 18-years) in randomly selected urban and rural areas from all eight divisions in Bangladesh. Descriptive data analysis was conducted to highlight the challenges for preventive practices and risk communications for COVID-19. Multiple logistic regression analysis was used to determine the sociodemographic groups vulnerable to these challenges. Lack of availability of protective equipment (44.4%), crowded living situations/workspaces (36.8%), inadequate information on the proper use of protective measures (21.9%), inadequate handwashing and sanitation facilities (17.6%), and negative influences on family/friends (17.4%) were identified as barriers to COVID-19 preventive practices. It was also found that males (OR = 1.3, 95% CI = 1.01, 1.7), rural residents (OR = 1.5, 95% CI = 1.2, 2), respondents with a low level of education: no schooling vs. \u2265higher secondary (OR = 3.5, 95% CI = 2.3, 5.2), primary vs. \u2265higher secondary (OR = 2.5, 95% CI = 1.7, 3.8), respondents engaged in agricultural (OR = 1.7, 95% CI = 1.2, 2.4), laboring (OR = 3.2, 95% CI = 2, 5), and domestic works (OR = 1.6, 95% CI = 1.07, 2.5), and people with disabilities (OR = 1.7, 95% CI = 1.1, 2.6) were all likely to have difficulty in practicing effective COVID-19 protective behaviors. Respondents' education and occupation were significant predictors of inadequate understanding of COVID-19 risk communications and was identified as a problem among 17.4% of the respondents. A substantial percentage of Bangladeshi adults have difficulty practising COVID-19 protective behaviours and have poor comprehension of risk communications, particularly in rural areas and among those with low education. This research can aid policymakers in developing tailored COVID-19 risk communications and mitigation strategies to help prevent future waves of the pandemic.", "doi": "10.3390/ijerph18179259", "pmid": "34501847", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph18179259"}], "notes": [], "created": "2021-09-13T06:24:36.671Z", "modified": "2021-11-18T14:03:05.334Z"}, {"entity": "publication", "iuid": "fc8723392b684de496dd9cd342b7d8d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc8723392b684de496dd9cd342b7d8d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc8723392b684de496dd9cd342b7d8d0"}}, "title": "Association of cardiometabolic risk factors with hospitalisation or death due to COVID-19: population-based cohort study in Sweden (SCAPIS).", "authors": [{"family": "Tornhammar", "given": "Per", "initials": "P"}, {"family": "Jernberg", "given": "Tomas", "initials": "T"}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G"}, {"family": "Blomberg", "given": "Anders", "initials": "A"}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G"}, {"family": "Engvall", "given": "Jan", "initials": "J"}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f34c0d3602439abe6096293c7c732d.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Janson", "given": "Christer", "initials": "C", "orcid": "0000-0001-5093-6980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba296cda8ef74430ad5457e71b7dae94.json"}}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Sk\u00f6ld", "given": "C Magnus", "initials": "CM"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "S\u00f6derberg", "given": "Stefan", "initials": "S", "orcid": "0000-0001-9225-1306", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9507251cd84369a92d7f552d65f79e.json"}}, {"family": "Zaigham", "given": "Suneela", "initials": "S"}, {"family": "\u00d6stgren", "given": "Carl Johan", "initials": "CJ"}, {"family": "Andersson", "given": "Daniel Peter", "initials": "DP", "orcid": "0000-0003-4655-4837", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e35f15e626c045c191bd14a522a85c0e.json"}}, {"family": "Ueda", "given": "Peter", "initials": "P", "orcid": "0000-0002-3275-8743", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b5966168cb44c01b62e46aed9c8a02c.json"}}], "type": "journal article", "published": "2021-09-02", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "9", "pages": "e051359"}, "abstract": "To assess the association of cardiometabolic risk factors with hospitalisation or death due to COVID-19 in the general population.\r\n\r\nSwedish population-based cohort including 29 955 participants.\r\n\r\nCardiometabolic risk factors assessed between 2014 and 2018.\r\n\r\nHospitalisation or death due to COVID-19, as registered in nationwide registers from 31 January 2020 through 12 September 2020. Associations of cardiometabolic risk factors with the outcome were assessed using logistic regression adjusted for age, sex, birthplace and education.\r\n\r\nMean (SD) age was 61.2 (4.5) and 51.5% were women. 69 participants experienced hospitalisation or death due to COVID-19. Examples of statistically significant associations between baseline factors and subsequent hospitalisation or death due to COVID-19 included overweight (adjusted OR (aOR) vs normal weight 2.73 (95% CI 1.25 to 5.94)), obesity (aOR vs normal weight 4.09 (95% CI 1.82 to 9.18)), pre-diabetes (aOR vs normoglycaemia 2.56 (95% CI 1.44 to 4.55)), diabetes (aOR vs normoglycaemia 3.96 (95% CI 2.13 to 7.36)), sedentary time (aOR per hour/day increase 1.10 (95% CI 1.02 to 1.17)), grade 2 hypertension (aOR vs normotension 2.44 (95% CI 1.10 to 5.44)) and high density lipoprotein cholesterol (aOR per mmol/L increase 0.33 (95% CI 0.17 to 0.65)). Statistically significant associations were not observed for grade 1 hypertension (aOR vs normotension 1.03 (95% CI 0.55 to 1.96)), current smoking (aOR 0.56 (95% CI 0.24 to 1.30)), total cholesterol (aOR per mmol/L increase 0.90 (95% CI 0.71 to 1.13)), low density lipoprotein cholesterol (aOR per mmol/L increase 0.90 (95% CI 0.69 to 1.15)) and coronary artery calcium score (aOR per 10 units increase 1.00 (95% CI 0.99 to 1.01)).\r\n\r\nIn a large population-based sample from the general population, several cardiometabolic risk factors were associated with hospitalisation or death due to COVID-19.", "doi": "10.1136/bmjopen-2021-051359", "pmid": "34475186", "labels": {"Funder: Hj\u00e4rt-Lungfonden": null, "Funder: Vinnova": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-051359"}, {"db": "pmc", "key": "PMC8413466"}], "notes": [], "created": "2021-09-06T06:01:30.773Z", "modified": "2022-02-08T19:27:17.375Z"}, {"entity": "publication", "iuid": "8b8a1eaec13f4f0ea95e51be6748dd97", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b8a1eaec13f4f0ea95e51be6748dd97.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b8a1eaec13f4f0ea95e51be6748dd97"}}, "title": "Iodide supplementation of the anti-viral duox-lactoperoxidase activity may prevent some SARS-CoV-2 infections.", "authors": [{"family": "Smith", "given": "Michael L", "initials": "ML", "orcid": "0000-0003-4103-8614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4c9b76424464a188d2880c45a0f4303.json"}}, {"family": "Sharma", "given": "Sujata", "initials": "S"}, {"family": "Singh", "given": "Tej P", "initials": "TP", "orcid": "0000-0002-2886-7963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4aa57530849449bb3fd877de0182529.json"}}], "type": "letter", "published": "2021-09-01", "journal": {"title": "Eur J Clin Nutr", "issn": "1476-5640", "issn-l": null}, "abstract": null, "doi": "10.1038/s41430-021-00995-2", "pmid": "34471253", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41430-021-00995-2"}, {"db": "pmc", "key": "PMC8408568"}], "notes": [], "created": "2021-09-06T06:15:56.793Z", "modified": "2021-09-06T06:15:56.866Z"}, {"entity": "publication", "iuid": "1122b9f54daf4494987a99f1daf28185", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1122b9f54daf4494987a99f1daf28185.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1122b9f54daf4494987a99f1daf28185"}}, "title": "Distinct Metabolic Profile Associated with a Fatal Outcome in COVID-19 Patients during the Early Epidemic in Italy.", "authors": [{"family": "Saccon", "given": "Elisa", "initials": "E"}, {"family": "Bandera", "given": "Alessandra", "initials": "A", "orcid": "0000-0001-9440-4601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5fc84c1fbbf42d1bba7d98ae000b3b0.json"}}, {"family": "Scium\u00e8", "given": "Mariarita", "initials": "M"}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "Lashari", "given": "Abid A", "initials": "AA"}, {"family": "Aliberti", "given": "Stefano", "initials": "S"}, {"family": "Sachs", "given": "Michael C", "initials": "MC"}, {"family": "Billi", "given": "Filippo", "initials": "F"}, {"family": "Blasi", "given": "Francesco", "initials": "F"}, {"family": "Gabriel", "given": "Erin E", "initials": "EE"}, {"family": "Costantino", "given": "Giorgio", "initials": "G"}, {"family": "De Roberto", "given": "Pasquale", "initials": "P"}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Gori", "given": "Andrea", "initials": "A"}, {"family": "Peyvandi", "given": "Flora", "initials": "F"}, {"family": "Scudeller", "given": "Luigia", "initials": "L", "orcid": "0000-0001-7240-9567", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09948bf33c1e40a294d256f8b905f117.json"}}, {"family": "Canetta", "given": "Ciro", "initials": "C"}, {"family": "Lorson", "given": "Christian L", "initials": "CL"}, {"family": "Valenti", "given": "Luca", "initials": "L"}, {"family": "Singh", "given": "Kamal", "initials": "K"}, {"family": "Baldini", "given": "Luca", "initials": "L"}, {"family": "Fracchiolla", "given": "Nicola Stefano", "initials": "NS"}, {"family": "COVID-19 Network Working Group,", "given": "", "initials": ""}, {"family": "Neogi", "given": "Ujjwal", "initials": "U", "orcid": "0000-0002-0844-3338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5c27a627463945d992d74005f8a60d88.json"}}], "type": "journal article", "published": "2021-09-01", "journal": {"title": "Microbiol Spectr", "issn": "2165-0497", "pages": "e0054921", "issn-l": null}, "abstract": "In one year of the coronavirus disease 2019 (COVID-19) pandemic, many studies have described the different metabolic changes occurring in COVID-19 patients, linking these alterations to the disease severity. However, a complete metabolic signature of the most severe cases, especially those with a fatal outcome, is still missing. Our study retrospectively analyzes the metabolome profiles of 75 COVID-19 patients with moderate and severe symptoms admitted to Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Lombardy Region, Italy) following SARS-CoV-2 infection between March and April 2020. Italy was the first Western country to experience COVID-19, and the Lombardy Region was the epicenter of the Italian COVID-19 pandemic. This cohort shows a higher mortality rate compared to others; therefore, it represents a unique opportunity to investigate the underlying metabolic profiles of the first COVID-19 patients in Italy and to identify the potential biomarkers related to the disease prognosis and fatal outcome. IMPORTANCE Understanding the metabolic alterations occurring during an infection is a key element for identifying potential indicators of the disease prognosis, which are fundamental for developing efficient diagnostic tools and offering the best therapeutic treatment to the patient. Here, exploiting high-throughput metabolomics data, we identified the first metabolic profile associated with a fatal outcome, not correlated with preexisting clinical conditions or the oxygen demand at the moment of diagnosis. Overall, our results contribute to a better understanding of COVID-19-related metabolic disruption and may represent a useful starting point for the identification of independent prognostic factors to be employed in therapeutic practice.", "doi": "10.1128/Spectrum.00549-21", "pmid": "34468185", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: VR": null}, "xrefs": [], "notes": [], "created": "2021-09-06T06:20:28.618Z", "modified": "2021-10-10T15:12:11.738Z"}, {"entity": "publication", "iuid": "e3844727d8014bef83b79b9022d2dbd8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3844727d8014bef83b79b9022d2dbd8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3844727d8014bef83b79b9022d2dbd8"}}, "title": "Active matrix metalloproteinase-8 (aMMP-8) point-of-care test (POCT) in the COVID-19 pandemic.", "authors": [{"family": "Sorsa", "given": "Timo", "initials": "T"}, {"family": "Sahni", "given": "Vaibhav", "initials": "V"}, {"family": "Buduneli", "given": "Nurcan", "initials": "N"}, {"family": "Gupta", "given": "Shipra", "initials": "S"}, {"family": "R\u00e4is\u00e4nen", "given": "Ismo T", "initials": "IT", "orcid": "0000-0001-5821-5299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5688183e182e4194888dc98301077bab.json"}}, {"family": "Golub", "given": "Lorne M", "initials": "LM"}, {"family": "Lee", "given": "Hsi-Ming", "initials": "HM"}, {"family": "P\u00e4til\u00e4", "given": "Tommi", "initials": "T"}, {"family": "Bostanci", "given": "Nagihan", "initials": "N"}, {"family": "Meurman", "given": "Jukka", "initials": "J", "orcid": "0000-0001-6702-6836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ebb40fd79c04c618b3ae2908a70d317.json"}}, {"family": "P\u00e4rn\u00e4nen", "given": "Pirjo", "initials": "P"}, {"family": "Nwhator", "given": "Solomon O", "initials": "SO"}, {"family": "Singla", "given": "Mohita", "initials": "M"}, {"family": "Gauba", "given": "Krishan", "initials": "K"}], "type": "journal article", "published": "2021-09-01", "journal": {"title": "Expert Rev Proteomics", "issn": "1744-8387", "issn-l": null}, "abstract": "Active matrix metalloproteinase (aMMP)-8 utilized in point-of-care testing (POCT) is regarded as a potential biomarker for periodontal and peri-implant diseases. Various host and microbial factors eventually influence the expression, degranulation, levels and activation of aMMP-8. The type of oral fluids (saliva, mouthrinse, gingival crevicular and peri-implant sulcular fluids [GCF/PISF], respectively) affect the analysis.\n\nWith this background, we aimed to review here the recent studies on practical, inexpensive, noninvasive and quantitative mouthrinse and GCF/PISF chair-side POCT lateral flow aMMP-8 immunoassays (PerioSafe and ImplantSafe/ORALyzer) and how they help to detect, predict, monitor the course, treatment and prevention of periodontitis and peri-implantitis. The correlations of aMMP-8 POCT to other independent and catalytic activity assays of MMP-8 are also addressed.\n\nThe mouthrinse aMMP-8 POCT can also detect prediabetes/diabetes and tissue destructive oral side-effects due to the head and neck cancers' radiotherapy. Chlorhexidine and doxycycline can inhibit collagenolytic human neutrophil and GCF aMMP-8. Furthermore, by a set of case-series we demonstrate the potential of mouthrinse aMMP-8 POCT to real-time/online detect periodontitis as a potential risk disease for coronavirus disease 2019 (COVID-19). The clinical interdisciplinary utilization of aMMP-8 POCT requires additional oral, medical and interdisciplinary studies.", "doi": "10.1080/14789450.2021.1976151", "pmid": "34468272", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-09-06T06:20:03.652Z", "modified": "2021-09-06T06:20:03.727Z"}, {"entity": "publication", "iuid": "d462e8f607604abbbff7f19df78740fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d462e8f607604abbbff7f19df78740fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d462e8f607604abbbff7f19df78740fc"}}, "title": "Vaccine effectiveness against infection with the Delta (B.1.617.2) variant, Norway, April to August 2021.", "authors": [{"family": "Sepp\u00e4l\u00e4", "given": "Elina", "initials": "E"}, {"family": "Veneti", "given": "Lamprini", "initials": "L"}, {"family": "Starrfelt", "given": "Jostein", "initials": "J"}, {"family": "Danielsen", "given": "Anders Skyrud", "initials": "AS"}, {"family": "Bragstad", "given": "Karoline", "initials": "K"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "Taxt", "given": "Arne Michael", "initials": "AM"}, {"family": "Watle", "given": "Sara Viksmoen", "initials": "SV"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "35", "pages": null}, "abstract": "Some variants of SARS-CoV-2 are associated with increased transmissibility, increased disease severity or decreased vaccine effectiveness (VE). In this population-based cohort study (n = 4,204,859), the Delta variant was identified in 5,430 (0.13%) individuals, of whom 84 were admitted to hospital. VE against laboratory confirmed infection with the Delta variant was 22.4% among partly vaccinated (95% confidence interval (CI): 17.0-27.4) and 64.6% (95% CI: 60.6-68.2) among fully vaccinated individuals, compared with 54.5% (95% CI: 50.4-58.3) and 84.4% (95%CI: 81.8-86.5) against the Alpha variant.", "doi": "10.2807/1560-7917.ES.2021.26.35.2100793", "pmid": "34477054", "labels": {"Category: Genomics & transcriptomics": null, "Category: Drug Discovery": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-09-06T05:53:34.921Z", "modified": "2021-11-29T06:15:04.418Z"}, {"entity": "publication", "iuid": "45a576151c394ef38702a583f1654699", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/45a576151c394ef38702a583f1654699.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/45a576151c394ef38702a583f1654699"}}, "title": "Unequal Labour Market Impacts of COVID-19 in Sweden \u2014 But Not Between Women and Men", "authors": [{"family": "Campa", "given": "Pamela", "initials": "P"}, {"family": "Roine", "given": "Jesper", "initials": "J"}, {"family": "Str\u00f6mberg", "given": "Svante", "initials": "S"}], "type": "journal-article", "published": "2021-09-00", "journal": {"title": "Intereconomics", "issn": "0020-5346", "issn-l": null, "volume": "56", "issue": "5", "pages": "264-269"}, "abstract": null, "doi": "10.1007/s10272-021-0996-3", "pmid": null, "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:52:36.938Z", "modified": "2022-11-23T08:52:04.923Z"}, {"entity": "publication", "iuid": "a0b638ade2174bf6ad9cea1ba3806e93", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a0b638ade2174bf6ad9cea1ba3806e93.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a0b638ade2174bf6ad9cea1ba3806e93"}}, "title": "Trust in the government increases financial well-being and general well-being during COVID-19.", "authors": [{"family": "Barrafrem", "given": "Kinga", "initials": "K"}, {"family": "Tingh\u00f6g", "given": "Gustav", "initials": "G"}, {"family": "V\u00e4stfj\u00e4ll", "given": "Daniel", "initials": "D"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "J Behav Exp Finance", "issn": "2214-6350", "issn-l": null, "volume": "31", "issue": null, "pages": "100514"}, "abstract": "We investigate the antecedents of subjective financial well-being and general well-being during the ongoing COVID-19 pandemic. In an online survey conducted in the midst of COVID-19 pandemic with over 1000 Swedish participants we found that distrust in the government to cope with financial (but not healthcare) challenges of the pandemic was negatively related to the feeling of financial security. In a structural equation model, we also show that trust in government to deal with financial challenges of COVID-19 pandemic has a significant impact on general well-being through the mediating channel of financial well-being. In addition, trust in government to deal with healthcare challenges of COVID-19 pandemic has a significant direct impact on individuals' general well-being. Our findings have important implications for public policy as they highlight the importance of citizens' trust in well-functioning governmental institutions to help cope with not only healthcare, but also financial challenges of an ongoing pandemic.", "doi": "10.1016/j.jbef.2021.100514", "pmid": "34545323", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2214-6350(21)00058-7"}, {"db": "pmc", "key": "PMC8444950"}], "notes": [], "created": "2021-10-27T05:11:02.378Z", "modified": "2021-11-18T14:01:18.560Z"}, {"entity": "publication", "iuid": "bf72161a487f403ab690c95bc4b98b16", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf72161a487f403ab690c95bc4b98b16.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf72161a487f403ab690c95bc4b98b16"}}, "title": "Thirty-Day Outcomes of Children and Adolescents With COVID-19: An International Experience.", "authors": [{"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "Vizcaya", "given": "David", "initials": "D"}, {"family": "Pistillo", "given": "Andrea", "initials": "A"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Lai", "given": "Lana Yin Hui", "initials": "LYH"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A"}, {"family": "Ahmed", "given": "Waheed-Ul-Rahman", "initials": "WU"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Burn", "given": "Edward", "initials": "E"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Blacketer", "given": "Clair", "initials": "C"}, {"family": "DuVall", "given": "Scott", "initials": "S"}, {"family": "Falconer", "given": "Thomas", "initials": "T"}, {"family": "Fernandez-Bertolin", "given": "Sergio", "initials": "S"}, {"family": "Fortin", "given": "Stephen", "initials": "S"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Gong", "given": "Mengchun", "initials": "M"}, {"family": "Tan", "given": "Eng Hooi", "initials": "EH"}, {"family": "Huser", "given": "Vojtech", "initials": "V"}, {"family": "Iveli", "given": "Pablo", "initials": "P"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Recalde", "given": "Martina", "initials": "M"}, {"family": "Roel", "given": "Elena", "initials": "E"}, {"family": "Schilling", "given": "Lisa M", "initials": "LM"}, {"family": "Shah", "given": "Nigam H", "initials": "NH"}, {"family": "Shah", "given": "Karishma", "initials": "K"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhang", "given": "Ying", "initials": "Y"}, {"family": "Williams", "given": "Andrew E", "initials": "AE"}, {"family": "Reich", "given": "Christian G", "initials": "CG"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Rijnbeek", "given": "Peter", "initials": "P"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}], "type": "comparative study", "published": "2021-09-00", "journal": {"title": "Pediatrics", "issn": "1098-4275", "volume": "148", "issue": "3", "pages": "e2020042929", "issn-l": null}, "abstract": "To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children and adolescents diagnosed or hospitalized with coronavirus disease 2019 (COVID-19) and to compare them in secondary analyses with patients diagnosed with previous seasonal influenza in 2017-2018.\n\nInternational network cohort using real-world data from European primary care records (France, Germany, and Spain), South Korean claims and US claims, and hospital databases. We included children and adolescents diagnosed and/or hospitalized with COVID-19 at age <18 between January and June 2020. We described baseline demographics, comorbidities, symptoms, 30-day in-hospital treatments, and outcomes including hospitalization, pneumonia, acute respiratory distress syndrome, multisystem inflammatory syndrome in children, and death.\n\nA total of 242 158 children and adolescents diagnosed and 9769 hospitalized with COVID-19 and 2 084 180 diagnosed with influenza were studied. Comorbidities including neurodevelopmental disorders, heart disease, and cancer were more common among those hospitalized with versus diagnosed with COVID-19. Dyspnea, bronchiolitis, anosmia, and gastrointestinal symptoms were more common in COVID-19 than influenza. In-hospital prevalent treatments for COVID-19 included repurposed medications (<10%) and adjunctive therapies: systemic corticosteroids (6.8%-7.6%), famotidine (9.0%-28.1%), and antithrombotics such as aspirin (2.0%-21.4%), heparin (2.2%-18.1%), and enoxaparin (2.8%-14.8%). Hospitalization was observed in 0.3% to 1.3% of the cohort diagnosed with COVID-19, with undetectable (n < 5 per database) 30-day fatality. Thirty-day outcomes including pneumonia and hypoxemia were more frequent in COVID-19 than influenza.\n\nDespite negligible fatality, complications including hospitalization, hypoxemia, and pneumonia were more frequent in children and adolescents with COVID-19 than with influenza. Dyspnea, anosmia, and gastrointestinal symptoms could help differentiate diagnoses. A wide range of medications was used for the inpatient management of pediatric COVID-19.", "doi": "10.1542/peds.2020-042929", "pmid": "34049958", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "peds.2020-042929"}], "notes": [], "created": "2021-06-04T11:38:07.570Z", "modified": "2023-06-19T15:35:04.313Z"}, {"entity": "publication", "iuid": "5f6e4c6729a14595bd3010f6bcb6218f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f6e4c6729a14595bd3010f6bcb6218f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f6e4c6729a14595bd3010f6bcb6218f"}}, "title": "The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages", "authors": [{"family": "Martin", "given": "Darren P", "initials": "DP"}, {"family": "Weaver", "given": "Steven", "initials": "S", "orcid": "0000-0002-6931-7191", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b28e228830204c0787e6e291c5504314.json"}}, {"family": "Tegally", "given": "Houriiyah", "initials": "H"}, {"family": "San", "given": "James Emmanuel", "initials": "JE", "orcid": "0000-0002-5736-664X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5229990d46874a5185d136b09fce716a.json"}}, {"family": "Shank", "given": "Stephen D", "initials": "SD"}, {"family": "Wilkinson", "given": "Eduan", "initials": "E"}, {"family": "Lucaci", "given": "Alexander G", "initials": "AG"}, {"family": "Giandhari", "given": "Jennifer", "initials": "J"}, {"family": "Naidoo", "given": "Sureshnee", "initials": "S"}, {"family": "Pillay", "given": "Yeshnee", "initials": "Y"}, {"family": "Singh", "given": "Lavanya", "initials": "L", "orcid": "0000-0002-1726-4454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bbfb5df3bc34277aa004bfcf9a3775b.json"}}, {"family": "Lessells", "given": "Richard J", "initials": "RJ"}, {"family": "Gupta", "given": "Ravindra K", "initials": "RK"}, {"family": "Wertheim", "given": "Joel O", "initials": "JO"}, {"family": "Nekturenko", "given": "Anton", "initials": "A"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Harkins", "given": "Gordon W", "initials": "GW"}, {"family": "Lemey", "given": "Philippe", "initials": "P"}, {"family": "MacLean", "given": "Oscar A", "initials": "OA"}, {"family": "Robertson", "given": "David L", "initials": "DL"}, {"family": "de Oliveira", "given": "Tulio", "initials": "T", "orcid": "0000-0002-3027-5254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3dadcb78141a496ba76769d69667bf79.json"}}, {"family": "Kosakovsky Pond", "given": "Sergei L", "initials": "SL"}], "type": "journal-article", "published": "2021-09-00", "journal": {"title": "Cell", "issn": "0092-8674", "issn-l": null}, "abstract": "The independent emergence late in 2020 of the B.1.1.7, B.1.351, and P.1 lineages of SARS-CoV-2 prompted renewed concerns about the evolutionary capacity of this virus to overcome public health interventions and rising population immunity. Here, by examining patterns of synonymous and non-synonymous mutations that have accumulated in SARS-CoV-2 genomes since the pandemic began, we find that the emergence of these three \"501Y lineages\" coincided with a major global shift in the selective forces acting on various SARS-CoV-2 genes. Following their emergence, the adaptive evolution of 501Y lineage viruses has involved repeated selectively favored convergent mutations at 35 genome sites, mutations we refer to as the 501Y meta-signature. The ongoing convergence of viruses in many other lineages on this meta-signature suggests that it includes multiple mutation combinations capable of promoting the persistence of diverse SARS-CoV-2 lineages in the face of mounting host immune recognition.", "doi": "10.1016/j.cell.2021.09.003", "pmid": "34537136", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0092-8674(21)01050-3"}, {"db": "pmc", "key": "PMC8421097"}, {"db": "URL", "key": "https://doi.org/10.5281/zenodo.5149112", "description": "Initial release of SARS-CoV2 variation data"}, {"db": "URL", "key": "https://observablehq.com/@spond/n501y-clades@3752", "description": "Visualizing selection analysis results for evolution of the B.1.351 clade"}, {"db": "URL", "key": "https://observablehq.com/@spond/sc2-selection-trends", "description": "Frequency trends and selection detection of subsets of sites in SARS-CoV-2 genes"}, {"db": "URL", "key": "https://observablehq.com/@spond/sc2-temporal-selection-trends", "description": "Temporal evolution of selective pressures on SARS-CoV-2 genes"}, {"db": "URL", "key": "https://github.com/spond/SARS-CoV-2-clade-analysis", "description": "Collection of result files and underlying sequence alignments processed by the RASCL SARS-CoV-2 clade analysis pipeline"}], "notes": [], "created": "2021-09-20T16:58:24.660Z", "modified": "2021-10-15T07:50:25.330Z"}, {"entity": "publication", "iuid": "a95b2d52208f4df0b81429ca74ff612c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a95b2d52208f4df0b81429ca74ff612c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a95b2d52208f4df0b81429ca74ff612c"}}, "title": "Socioeconomic patterns and COVID-19 outcomes before, during and after the lockdown in Italy (2020).", "authors": [{"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Rosano", "given": "Aldo", "initials": "A"}, {"family": "Vescio", "given": "Maria Fenicia", "initials": "MF"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Regidor", "given": "Enrique", "initials": "E"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Health Place", "issn": "1873-2054", "issn-l": null, "volume": "71", "issue": null, "pages": "102642"}, "abstract": "The objective was to investigate the association between deprivation and COVID-19 outcomes in Italy during pre-lockdown, lockdown and post-lockdown periods using a retrospective cohort study with 38,534,169 citizens and 222,875 COVID-19 cases. Multilevel negative binomial regression models, adjusting for age, sex, population-density and region of residence were conducted to evaluate the association between area-level deprivation and COVID-19 incidence, case-hospitalisation rate and case-fatality. During lockdown and post-lockdown, but not during pre-lockdown, higher incidence of cases was observed in the most deprived municipalities compared with the least deprived ones. No differences in case-hospitalisation and case-fatality according to deprivation were observed in any period under study.", "doi": "10.1016/j.healthplace.2021.102642", "pmid": "34339938", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1353-8292(21)00138-6"}, {"db": "pmc", "key": "PMC8318679"}], "notes": [], "created": "2021-08-04T10:11:02.697Z", "modified": "2021-11-18T12:43:33.213Z"}, {"entity": "publication", "iuid": "cad7e895541f4af7a873cdfaf3742488", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cad7e895541f4af7a873cdfaf3742488.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cad7e895541f4af7a873cdfaf3742488"}}, "title": "Severe features during outbreak but low mortality observed immediately before and after a March-May 2020 COVID-19 outbreak in Stockholm, Sweden.", "authors": [{"family": "Pimenoff", "given": "Ville N", "initials": "VN"}, {"family": "Bj\u00f6rnstedt", "given": "Mikael", "initials": "M"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": "110", "issue": null, "pages": "433-435"}, "abstract": "The aim of this study was to estimate how well the excess mortality reflected the burden of coronavirus disease 2019 (COVID-19)-related deaths during the March-May 2020 COVID-19 outbreak in Stockholm, Sweden, and whether the excess mortality during the outbreak might have resulted in a compensatory reduced mortality after the outbreak.\n\nUsing previous 10-year or 5-year average mortality rates as a baseline, the excess mortality estimates before, during, and after the COVID-19 outbreak in March-May 2020 in Stockholm were compared.\n\nWeekly death estimates revealed that the immediate pre-outbreak and post-outbreak all-cause mortality did not exceed to excess mortality regardless of whether previous 10-year or 5-year average mortality was used. Forty-three days after the start of the outbreak, 74.4% of the total excess mortality was reportedly explained by known COVID-19-related deaths, and the present study reports an update, showing that 15 weeks after the start of the outbreak, the reported COVID-19-related deaths explained >99% of the total excess mortality.\n\nAn exceptional outbreak feature of rapid excess mortality was observed. However, no excess but similarly low mortality was observed immediately prior to the outbreak and post-outbreak, thus emphasizing the severity of the first wave of the COVID-19 outbreak in Stockholm.", "doi": "10.1016/j.ijid.2021.08.005", "pmid": "34375761", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)00637-8"}, {"db": "pmc", "key": "PMC8349439"}], "notes": [], "created": "2021-08-11T14:26:46.302Z", "modified": "2021-11-18T13:29:36.379Z"}, {"entity": "publication", "iuid": "b03b9a4143de4683b96849ba0bfa5111", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b03b9a4143de4683b96849ba0bfa5111.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b03b9a4143de4683b96849ba0bfa5111"}}, "title": "Risk of severe COVID-19 infection in International Space Station astronauts despite routine pre-mission measures.", "authors": [{"family": "Javad Mortazavi", "given": "Seyed Mohammad", "initials": "SM"}, {"family": "Mortazavi", "given": "Seyed Alireza", "initials": "SA"}, {"family": "Sihver", "given": "Lembit", "initials": "L"}], "type": "letter", "published": "2021-09-00", "journal": {"title": "J Allergy Clin Immunol Pract", "issn": "2213-2201", "volume": "9", "issue": "9", "pages": "3527", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jaip.2021.05.043", "pmid": "34507714", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-2198(21)00700-5"}], "notes": [], "created": "2021-09-13T06:26:57.018Z", "modified": "2021-09-13T06:26:57.029Z"}, {"entity": "publication", "iuid": "4695e8c834724f698d86079fff003688", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4695e8c834724f698d86079fff003688.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4695e8c834724f698d86079fff003688"}}, "title": "Rapid policy development for essential RMNCAH services in sub-Saharan Africa: what happened during the COVID-19 pandemic and what needs to happen going forward?", "authors": [{"family": "Waiswa", "given": "Peter", "initials": "P"}, {"family": "Wanduru", "given": "Phillip", "initials": "P", "orcid": "0000-0001-5934-2505", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/964f6d1176b747c7a00ea484da84d763.json"}}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "9", "issn-l": "2059-7908"}, "abstract": null, "doi": "10.1136/bmjgh-2021-006938", "pmid": "34526322", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-006938"}], "notes": [], "created": "2021-09-20T16:25:22.680Z", "modified": "2021-09-20T16:26:08.136Z"}, {"entity": "publication", "iuid": "5f788fe67f124e149aa2acc87db98309", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f788fe67f124e149aa2acc87db98309.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f788fe67f124e149aa2acc87db98309"}}, "title": "Prolonged Effects of the COVID-19 Pandemic on Sleep Medicine Services-Longitudinal Data from the Swedish Sleep Apnea Registry.", "authors": [{"family": "Grote", "given": "Ludger", "initials": "L"}, {"family": "Theorell-Hagl\u00f6w", "given": "Jenny", "initials": "J"}, {"family": "Ulander", "given": "Martin", "initials": "M"}, {"family": "Hedner", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Sleep Med Clin", "issn": "1556-4088", "volume": "16", "issue": "3", "pages": "409-416", "issn-l": null}, "abstract": "The worldwide COVID-19 pandemic has affected the operation of health care systems. The direct impact of obstructive sleep apnea (OSA) on COVID-19 infection outcome remains to be elucidated. However, the coincidence of common risk factors for OSA and severe COVID-19 suggests that patients with OSA receiving positive airway pressure therapy may have an advantage relative to those untreated when confronted with a COVID-19 infection. The ongoing COVID-19 pandemic has led to a substantial reduction of sleep medicine services, and the long-term consequences may be considerable. New strategies for the management of sleep disorders are needed to overcome the current underdiagnosis and delay of treatment.", "doi": "10.1016/j.jsmc.2021.05.008", "pmid": "34325820", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1556-407X(21)00037-0"}, {"db": "pmc", "key": "PMC8258548"}], "notes": [], "created": "2021-08-04T17:06:04.153Z", "modified": "2021-08-04T17:06:05.747Z"}, {"entity": "publication", "iuid": "24858b2248dd4d2fb059a4a6d3bbd9b7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24858b2248dd4d2fb059a4a6d3bbd9b7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24858b2248dd4d2fb059a4a6d3bbd9b7"}}, "title": "Persistent symptoms in Swedish children after hospitalisation due to COVID-19.", "authors": [{"family": "Sterky", "given": "Ellinor", "initials": "E", "orcid": "0000-0003-3375-133X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8391aeb720cb4ebba5786f3a36ea4412.json"}}, {"family": "Olsson-\u00c5kefeldt", "given": "Selma", "initials": "S", "orcid": "0000-0002-9429-4163", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cdc01b4c2be3486d93d3d7126f6bb78f.json"}}, {"family": "Hertting", "given": "Olof", "initials": "O", "orcid": "0000-0002-0813-7998", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2be33c918eb644a48c6e33d730b2482b.json"}}, {"family": "Herlenius", "given": "Eric", "initials": "E", "orcid": "0000-0002-6859-0620", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8435b38e1704191a54140c72dae0b42.json"}}, {"family": "Alfven", "given": "Tobias", "initials": "T", "orcid": "0000-0002-2328-3512", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3851560b984401780a380ab1262cd8b.json"}}, {"family": "Ryd Rinder", "given": "Malin", "initials": "M", "orcid": "0000-0002-2947-4117", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b87e79413e84d8bb0a71a16fa3975fc.json"}}, {"family": "Rhedin", "given": "Samuel", "initials": "S", "orcid": "0000-0001-5798-2875", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1ee9f85f72942ed94646ba9d15cede0.json"}}, {"family": "Hildenwall", "given": "Helena", "initials": "H", "orcid": "0000-0001-7570-9792", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b715a8b59a84c6fb25e72d6a43753e5.json"}}], "type": "letter", "published": "2021-09-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": "110", "issue": "9", "pages": "2578-2580"}, "abstract": "COVID-19 is generally mild in children1 and post-acute inflammatory conditions that are temporally associated with the virus are rare, but potentially severe. However, some children and adults experience persistent symptoms after COVID-19. 2 Long COVID has not been precisely defined, but one study reported symptoms approximately 60 days after the primary diagnosis.3 Although adult long COVID is increasingly being studied, the magnitude of persistent symptoms in children remains unclear.", "doi": "10.1111/apa.15999", "pmid": "34157167", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-28T17:56:03.366Z", "modified": "2021-08-16T14:23:57.296Z"}, {"entity": "publication", "iuid": "0349bf593ecb49c6bf12f56d3df2dc6f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0349bf593ecb49c6bf12f56d3df2dc6f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0349bf593ecb49c6bf12f56d3df2dc6f"}}, "title": "Online consultations in mental healthcare during the COVID-19 outbreak: An international survey study on professionals' motivations and perceived barriers.", "authors": [{"family": "De Witte", "given": "Nele A J", "initials": "NAJ"}, {"family": "Carlbring", "given": "Per", "initials": "P"}, {"family": "Etzelmueller", "given": "Anne", "initials": "A"}, {"family": "Nordgreen", "given": "Tine", "initials": "T"}, {"family": "Karekla", "given": "Maria", "initials": "M"}, {"family": "Haddouk", "given": "Lise", "initials": "L"}, {"family": "Belmont", "given": "Ang\u00e9lique", "initials": "A"}, {"family": "\u00d8verland", "given": "Svein", "initials": "S"}, {"family": "Abi-Habib", "given": "Rudy", "initials": "R"}, {"family": "Bernaerts", "given": "Sylvie", "initials": "S"}, {"family": "Brugnera", "given": "Agostino", "initials": "A"}, {"family": "Compare", "given": "Angelo", "initials": "A"}, {"family": "Duque", "given": "Aranzazu", "initials": "A"}, {"family": "Ebert", "given": "David Daniel", "initials": "DD"}, {"family": "Eimontas", "given": "Jonas", "initials": "J"}, {"family": "Kassianos", "given": "Angelos P", "initials": "AP"}, {"family": "Salgado", "given": "Jo\u00e3o", "initials": "J"}, {"family": "Schwerdtfeger", "given": "Andreas", "initials": "A"}, {"family": "Tohme", "given": "Pia", "initials": "P"}, {"family": "Van Assche", "given": "Eva", "initials": "E"}, {"family": "Van Daele", "given": "Tom", "initials": "T"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Internet Interv", "issn": "2214-7829", "issn-l": "2214-7829", "volume": "25", "issue": null, "pages": "100405"}, "abstract": "While the general uptake of e-mental health interventions remained low over the past years, physical distancing and lockdown measures relating to the COVID-19 pandemic created a need and demand for online consultations in only a matter of weeks.\r\n\r\nThis study investigates the uptake of online consultations provided by mental health professionals during lockdown measures in the first wave of the COVID-19 pandemic in the participating countries, with a specific focus on professionals' motivations and perceived barriers regarding online consultations.\r\n\r\nAn online survey on the use of online consultations was set up in March 2020. The Unified Theory of Acceptance and Use of Technology (UTAUT) guided the deductive qualitative analysis of the results.\r\n\r\nIn total, 2082 mental health professionals from Austria, Belgium, Cyprus, France, Germany, Italy, Lebanon, Lithuania, the Netherlands, Norway, Portugal, Spain, and Sweden were included. The results showed a high uptake of online consultations during the COVID-19 pandemic but limited previous training on this topic undergone by mental health professionals. Most professionals reported positive experiences with online consultations, but concerns about the performance of online consultations in a mental health context (e.g., in terms of relational aspects) and practical considerations (e.g., relating to privacy and security of software) appear to be major barriers that hinder implementation.\r\n\r\nThis study provides an overview of the mental health professionals' actual needs and concerns regarding the use of online consultations in order to highlight areas of possible intervention and allow the implementation of necessary governmental, educational, and instrumental support so that online consultations can become a feasible and stable option in mental healthcare.", "doi": "10.1016/j.invent.2021.100405", "pmid": "34401365", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2214-7829(21)00045-2"}, {"db": "pmc", "key": "PMC8350604"}], "notes": [], "created": "2021-08-18T07:32:00.562Z", "modified": "2021-11-18T13:57:18.398Z"}, {"entity": "publication", "iuid": "d3e60a40b96a49e48c21639c683b0aea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3e60a40b96a49e48c21639c683b0aea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3e60a40b96a49e48c21639c683b0aea"}}, "title": "Nordic responses to Covid-19: Governance and policy measures in the early phases of the pandemic", "authors": [{"family": "Saunes", "given": "Ingrid Sperre", "initials": "IS"}, {"family": "Vrangb\u00e6k", "given": "Karsten", "initials": "K"}, {"family": "Byrkjeflot", "given": "Haldor", "initials": "H"}, {"family": "Jervelund", "given": "Signe Smith", "initials": "SS"}, {"family": "Birk", "given": "Hans Okkels", "initials": "HO"}, {"family": "Tynkkynen", "given": "Liina Kaisa", "initials": "LK"}, {"family": "Keskim\u00e4ki", "given": "Ilmo", "initials": "I"}, {"family": "Sigurgeirsd\u00f3ttir", "given": "Sigurbj\u00f6rg", "initials": "S"}, {"family": "Janl\u00f6v", "given": "Nils", "initials": "N"}, {"family": "Ramsberg", "given": "Joakim", "initials": "J"}, {"family": "Hern\u00e1ndez-Quevedo", "given": "Cristina", "initials": "C"}, {"family": "Merkur", "given": "Sherry", "initials": "S"}, {"family": "Sagan", "given": "Anna", "initials": "A"}, {"family": "Karanikolos", "given": "Marina", "initials": "M"}], "type": "journal-article", "published": "2021-09-00", "journal": {"title": "Health Policy", "issn": "0168-8510", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/j.healthpol.2021.08.011", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:53:23.797Z", "modified": "2021-11-18T13:56:16.670Z"}, {"entity": "publication", "iuid": "3ffba70f864142d6b721bc583d93b2f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ffba70f864142d6b721bc583d93b2f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ffba70f864142d6b721bc583d93b2f9"}}, "title": "Lung transplant after 6 months on ECMO support for SARS-CoV-2-induced ARDS complicated by severe antibody-mediated rejection.", "authors": [{"family": "Lindstedt", "given": "Sandra", "initials": "S", "orcid": "0000-0003-4484-6473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0739b93800374fa789184d52aa753ffa.json"}}, {"family": "Grins", "given": "Edgar", "initials": "E"}, {"family": "Larsson", "given": "Hillevi", "initials": "H"}, {"family": "Nilsson", "given": "Johan", "initials": "J"}, {"family": "Akbarshahi", "given": "Hamid", "initials": "H"}, {"family": "Silva", "given": "Iran", "initials": "I"}, {"family": "Hyllen", "given": "Snejana", "initials": "S"}, {"family": "Wagner", "given": "Darcy", "initials": "D", "orcid": "0000-0003-3794-1309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a62680154e2e4ae2b7cec2c44af06c9a.json"}}, {"family": "Sj\u00f6gren", "given": "Johan", "initials": "J"}, {"family": "Hansson", "given": "Lennart", "initials": "L"}, {"family": "Ederoth", "given": "Per", "initials": "P"}, {"family": "Gustafsson", "given": "Ronny", "initials": "R"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "BMJ Open Respir Res", "issn": "2052-4439", "volume": "8", "issue": "1", "issn-l": null}, "abstract": "There have been a few reports of successful lung transplantation (LTx) in patients with SARS-CoV-2-induced acute respiratory distress syndrome (ARDS); however, all reports were with rather short follow-up. Here we present a 62-year-old man without prior lung diseases. Following SARS-CoV-2-induced ARDS and 6 months of extracorporeal membrane oxygenation, he underwent LTx. 3 months post-transplantation he developed acute hypoxia requiring emergency intubation. Chest imaging showed acute rejection, and de novo DQ8-DSA was discovered. He was treated with a high dose of corticosteroids and plasmapheresis and was extubated 4 days later, yet the de novo DQ8-DSA remained. After sessions of plasmapheresis and rituximab, the levels of de novo DQ8-DSA remained unchanged. Nine months post-transplantation the patient died of respiratory failure. We herein discuss the decision to transplant, the transplantation itself and the postoperative course with severe antibody-mediated rejection. In addition, we evaluated the histological changes of the explanted lungs and compared these with end-stage idiopathic pulmonary fibrosis tissue, where both similarities and differences are seen. With the current case experience, one might consider close monitoring regarding DSA, and gives further support that LTx should only be considered for very carefully selected patients.", "doi": "10.1136/bmjresp-2021-001036", "pmid": "34544734", "labels": {"Category: Health": null}, "xrefs": [{"db": "pii", "key": "8/1/e001036"}, {"db": "pmc", "key": "PMC8453592"}], "notes": [], "created": "2021-10-10T15:39:44.215Z", "modified": "2021-10-10T15:39:44.257Z"}, {"entity": "publication", "iuid": "9e954c97139b41d2b1149ef29da764ba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9e954c97139b41d2b1149ef29da764ba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9e954c97139b41d2b1149ef29da764ba"}}, "title": "Loop-Mediated Isothermal Amplification Detection of SARS-CoV-2 and Myriad Other Applications.", "authors": [{"family": "Moore", "given": "Keith J M", "initials": "KJM"}, {"family": "Cahill", "given": "Jeremy", "initials": "J"}, {"family": "Aidelberg", "given": "Guy", "initials": "G"}, {"family": "Aronoff", "given": "Rachel", "initials": "R"}, {"family": "Bekta\u015f", "given": "Ali", "initials": "A"}, {"family": "Bezdan", "given": "Daniela", "initials": "D"}, {"family": "Butler", "given": "Daniel J", "initials": "DJ"}, {"family": "Chittur", "given": "Sridar V", "initials": "SV"}, {"family": "Codyre", "given": "Martin", "initials": "M"}, {"family": "Federici", "given": "Fernan", "initials": "F"}, {"family": "Tanner", "given": "Nathan A", "initials": "NA"}, {"family": "Tighe", "given": "Scott W", "initials": "SW"}, {"family": "True", "given": "Randy", "initials": "R"}, {"family": "Ware", "given": "Sarah B", "initials": "SB"}, {"family": "Wyllie", "given": "Anne L", "initials": "AL"}, {"family": "Afshin", "given": "Evan E", "initials": "EE"}, {"family": "Bendesky", "given": "Andres", "initials": "A"}, {"family": "Chang", "given": "Connie B", "initials": "CB"}, {"family": "Dela Rosa", "given": "Richard", "initials": "R"}, {"family": "Elhaik", "given": "Eran", "initials": "E"}, {"family": "Erickson", "given": "David", "initials": "D"}, {"family": "Goldsborough", "given": "Andrew S", "initials": "AS"}, {"family": "Grills", "given": "George", "initials": "G"}, {"family": "Hadasch", "given": "Kathrin", "initials": "K"}, {"family": "Hayden", "given": "Andrew", "initials": "A"}, {"family": "Her", "given": "Seong-Young", "initials": "SY"}, {"family": "Karl", "given": "Julie A", "initials": "JA"}, {"family": "Kim", "given": "Chang Hee", "initials": "CH"}, {"family": "Kriegel", "given": "Alison J", "initials": "AJ"}, {"family": "Kunstman", "given": "Thomas", "initials": "T"}, {"family": "Landau", "given": "Zeph", "initials": "Z"}, {"family": "Land", "given": "Kevin", "initials": "K"}, {"family": "Langhorst", "given": "Bradley W", "initials": "BW"}, {"family": "Lindner", "given": "Ariel B", "initials": "AB"}, {"family": "Mayer", "given": "Benjamin E", "initials": "BE"}, {"family": "McLaughlin", "given": "Lee A", "initials": "LA"}, {"family": "McLaughlin", "given": "Matthew T", "initials": "MT"}, {"family": "Molloy", "given": "Jenny", "initials": "J"}, {"family": "Mozsary", "given": "Christopher", "initials": "C"}, {"family": "Nadler", "given": "Jerry L", "initials": "JL"}, {"family": "D'Silva", "given": "Melinee", "initials": "M"}, {"family": "Ng", "given": "David", "initials": "D"}, {"family": "O'Connor", "given": "David H", "initials": "DH"}, {"family": "Ongerth", "given": "Jerry E", "initials": "JE"}, {"family": "Osuolale", "given": "Olayinka", "initials": "O"}, {"family": "Pinharanda", "given": "Ana", "initials": "A"}, {"family": "Plenker", "given": "Dennis", "initials": "D"}, {"family": "Ranjan", "given": "Ravi", "initials": "R"}, {"family": "Rosbash", "given": "Michael", "initials": "M"}, {"family": "Rotem", "given": "Assaf", "initials": "A"}, {"family": "Segarra", "given": "Jacob", "initials": "J"}, {"family": "Sch\u00fcrer", "given": "Stephan", "initials": "S"}, {"family": "Sherrill-Mix", "given": "Scott", "initials": "S"}, {"family": "Solo-Gabriele", "given": "Helena", "initials": "H"}, {"family": "To", "given": "Shaina", "initials": "S"}, {"family": "Vogt", "given": "Merly C", "initials": "MC"}, {"family": "Yu", "given": "Albert D", "initials": "AD"}, {"family": "Mason", "given": "Christopher E", "initials": "CE"}, {"family": "gLAMP Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "J Biomol Tech", "issn": "1943-4731", "volume": "32", "issue": "3", "pages": "228-275", "issn-l": null}, "abstract": "As the second year of the COVID-19 pandemic begins, it remains clear that a massive increase in the ability to test for SARS-CoV-2 infections in a myriad of settings is critical to controlling the pandemic and to preparing for future outbreaks. The current gold standard for molecular diagnostics is the polymerase chain reaction (PCR), but the extraordinary and unmet demand for testing in a variety of environments means that both complementary and supplementary testing solutions are still needed. This review highlights the role that loop-mediated isothermal amplification (LAMP) has had in filling this global testing need, providing a faster and easier means of testing, and what it can do for future applications, pathogens, and the preparation for future outbreaks. This review describes the current state of the art for research of LAMP-based SARS-CoV-2 testing, as well as its implications for other pathogens and testing. The authors represent the global LAMP (gLAMP) Consortium, an international research collective, which has regularly met to share their experiences on LAMP deployment and best practices; sections are devoted to all aspects of LAMP testing, including preanalytic sample processing, target amplification, and amplicon detection, then the hardware and software required for deployment are discussed, and finally, a summary of the current regulatory landscape is provided. Included as well are a series of first-person accounts of LAMP method development and deployment. The final discussion section provides the reader with a distillation of the most validated testing methods and their paths to implementation. This review also aims to provide practical information and insight for a range of audiences: for a research audience, to help accelerate research through sharing of best practices; for an implementation audience, to help get testing up and running quickly; and for a public health, clinical, and policy audience, to help convey the breadth of the effect that LAMP methods have to offer.", "doi": "10.7171/jbt.21-3203-017", "pmid": "35136384", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8802757"}], "notes": [], "created": "2022-02-11T10:32:09.826Z", "modified": "2022-02-11T10:32:17.965Z"}, {"entity": "publication", "iuid": "85dcee06080e4aea9c86f5392da1999d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/85dcee06080e4aea9c86f5392da1999d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/85dcee06080e4aea9c86f5392da1999d"}}, "title": "Hepatitis C elimination in Sweden: Progress, challenges and opportunities for growth in the time of COVID-19.", "authors": [{"family": "Blach", "given": "Sarah", "initials": "S", "orcid": "0000-0002-9252-7576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25f4327805304f1fb1e3a1c656968937.json"}}, {"family": "Blom\u00e9", "given": "Marianne", "initials": "M"}, {"family": "Duberg", "given": "Ann-Sofi", "initials": "AS"}, {"family": "Jerkeman", "given": "Anna", "initials": "A"}, {"family": "K\u00e5berg", "given": "Martin", "initials": "M", "orcid": "0000-0001-6643-3245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/514db56665594916b97164f5084f7496.json"}}, {"family": "Klasa", "given": "Per-Erik", "initials": "PE"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Razavi-Shearer", "given": "Devin", "initials": "D", "orcid": "0000-0003-4135-1053", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d60126b540b49eb937bbb31d8ac45cb.json"}}, {"family": "Razavi", "given": "Homie", "initials": "H"}, {"family": "Aleman", "given": "Soo", "initials": "S", "orcid": "0000-0003-0461-4870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b0edb2db8d840989936f67047ce91de.json"}}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Liver Int", "issn": "1478-3231", "volume": "41", "issue": "9", "pages": "2024-2031", "issn-l": null}, "abstract": "In 2014, the burden of hepatitis C virus (HCV) in Sweden was evaluated, to establish a baseline and inform public health interventions. Considering the changing landscape of HCV treatment, prevention, and care, and in light of the COVID-19 pandemic, this analysis seeks to evaluate Sweden's progress towards the World Health Organization (WHO) elimination targets and identify remaining barriers.\n\nThe data used for modelling HCV transmission and disease burden in Sweden were obtained through literature review, unpublished sources and expert input. A dynamic Markov model was employed to forecast population sizes and incidence of HCV through 2030. Two scenarios ('2019 Base' and 'WHO Targets') were developed to evaluate Sweden's progress towards HCV elimination.\n\nAt the beginning of 2019, there were 29 700 (95% uncertainty interval: 19 300-33 700) viremic infections in Sweden. Under the base scenario, Sweden would achieve and exceed the WHO targets for diagnosis, treatment and liver-related death. However, new infections would decrease by less than 10%, relative to 2015. Achieving all WHO targets by 2030 would require (i) expanding harm reduction programmes to reach more than 90% of people who inject drugs (PWID) and (ii) treating 90% of HCV + PWID engaged in harm reduction programmes and \u22657% of PWID not involved in harm reduction programmes, annually by 2025.\n\nIt is of utmost importance that Sweden, and all countries, find sustainability in HCV programmes by broadening the setting and base of providers to provide stability and continuity of care during turbulent times.", "doi": "10.1111/liv.14978", "pmid": "34051065", "labels": {"Category: Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8242794"}], "notes": [], "created": "2023-01-13T14:46:38.274Z", "modified": "2023-01-13T14:46:48.471Z"}, {"entity": "publication", "iuid": "56cc843c98694345a065e7e0b108c56c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56cc843c98694345a065e7e0b108c56c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56cc843c98694345a065e7e0b108c56c"}}, "title": "Experiences and motives of retirement-aged workers during the first wave of COVID-19 in Slovenia: \"This was the first time in 40 years that I really saw spring\".", "authors": [{"family": "Bratun", "given": "Ur\u0161a", "initials": "U"}, {"family": "Asaba", "given": "Eric", "initials": "E"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "J Aging Stud", "issn": "1879-193X", "volume": "58", "pages": "100954", "issn-l": null}, "abstract": "Choosing to continue working after retirement eligibility can attract both negative and positive sentiments from the general public. Studies examining the motivations of older workers have so far been conducted in times of relative social and economic stability. However, little is known about what it means for older workers to work during a lockdown or pandemic situation. The present longitudinal study aimed to explore experiences of retirement-aged workers in Slovenia in relation to their motives for prolonged work activity amid the COVID-19 pandemic, using the theory of gerotranscendence as a theoretical framework. Nine workers were interviewed before and after the start of the pandemic. The qualitative analysis was based on 18 interviews and observations, juxtaposing two analytical methods in order to illustrate common themes across the data as well as tensions in specific situations within a narrative context. Four main themes are presented: Unchanged plans, Motive developments, Psychological preparation for retirement and Views of society. In addition, a narrative analysis is presented with a focus on self-transcending elements in some of the participants' narratives. The findings suggest that during a pandemic, older workers' individual experiences might be constructed more positively compared to other groups, especially if they develop agentic identity and pursue meaningful activities. We discuss an innovative approach to gerotranscendence, complementing this theory with concepts from occupational science to develop a clearer distinction from the now dated disengagement theory and examine the life trajectories of older workers in novel situations such as a pandemic.", "doi": "10.1016/j.jaging.2021.100954", "pmid": "34425986", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0890-4065(21)00044-X"}], "notes": [], "created": "2021-08-27T09:39:07.384Z", "modified": "2021-11-18T13:54:38.271Z"}, {"entity": "publication", "iuid": "deba1acb96974c1b9756c04ed740d482", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/deba1acb96974c1b9756c04ed740d482.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/deba1acb96974c1b9756c04ed740d482"}}, "title": "Essential Emergency and Critical Care: a consensus among global clinical experts.", "authors": [{"family": "Schell", "given": "Carl Otto", "initials": "CO", "orcid": "0000-0002-7904-1336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a40b337b45b471d97a102c355c9d874.json"}}, {"family": "Khalid", "given": "Karima", "initials": "K"}, {"family": "Wharton-Smith", "given": "Alexandra", "initials": "A", "orcid": "0000-0001-5335-2059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40347c37da324b1ab41667d9ecd71fd5.json"}}, {"family": "Oliwa", "given": "Jacquie", "initials": "J"}, {"family": "Sawe", "given": "Hendry R", "initials": "HR", "orcid": "0000-0002-0395-5385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b51230cf1724ae98dc3b0e3f438dcb1.json"}}, {"family": "Roy", "given": "Nobhojit", "initials": "N", "orcid": "0000-0003-2022-7416", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cfd30f7c54f481986b006f34ad4a541.json"}}, {"family": "Sanga", "given": "Alex", "initials": "A"}, {"family": "Marshall", "given": "John C", "initials": "JC", "orcid": "0000-0002-7902-6291", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4584172f0eb464caff9299d93cc2b71.json"}}, {"family": "Rylance", "given": "Jamie", "initials": "J"}, {"family": "Hanson", "given": "Claudia", "initials": "C", "orcid": "0000-0001-8066-7873", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c06a2e703c840788ccdf3b2c4c972bc.json"}}, {"family": "Kayambankadzanja", "given": "Raphael K", "initials": "RK"}, {"family": "Wallis", "given": "Lee A", "initials": "LA", "orcid": "0000-0003-2711-3139", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8564386ba3be49d3a3d8282952cfabf0.json"}}, {"family": "Jirwe", "given": "Maria", "initials": "M", "orcid": "0000-0003-4570-4047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b89bcaacee5b47c4bb55ecc43a5e07f0.json"}}, {"family": "Baker", "given": "Tim", "initials": "T", "orcid": "0000-0001-8727-7018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1454fc20049b4d47865268adf16d104a.json"}}, {"family": "EECC Collaborators", "given": "", "initials": ""}, {"family": "EECC Collaborators*", "given": "", "initials": ""}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "9", "issn-l": "2059-7908"}, "abstract": "Globally, critical illness results in millions of deaths every year. Although many of these deaths are potentially preventable, the basic, life-saving care of critically ill patients are often overlooked in health systems. Essential Emergency and Critical Care (EECC) has been devised as the care that should be provided to all critically ill patients in all hospitals in the world. EECC includes the effective care of low cost and low complexity for the identification and treatment of critically ill patients across all medical specialties. This study aimed to specify the content of EECC and additionally, given the surge of critical illness in the ongoing pandemic, the essential diagnosis-specific care for critically ill patients with COVID-19.\n\nIn a Delphi process, consensus (>90% agreement) was sought from a diverse panel of global clinical experts. The panel iteratively rated proposed treatments and actions based on previous guidelines and the WHO/ICRC's Basic Emergency Care. The output from the Delphi was adapted iteratively with specialist reviewers into a coherent and feasible package of clinical processes plus a list of hospital readiness requirements.\n\nThe 269 experts in the Delphi panel had clinical experience in different acute medical specialties from 59 countries and from all resource settings. The agreed EECC package contains 40 clinical processes and 67 requirements, plus additions specific for COVID-19.\n\nThe study has specified the content of care that should be provided to all critically ill patients. Implementing EECC could be an effective strategy for policy makers to reduce preventable deaths worldwide.", "doi": "10.1136/bmjgh-2021-006585", "pmid": "34548380", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-006585"}, {"db": "pmc", "key": "PMC8458367"}], "notes": [], "created": "2021-10-27T05:12:13.486Z", "modified": "2021-10-27T05:12:13.770Z"}, {"entity": "publication", "iuid": "81e107e78c0f4c01abbe63f378d1c489", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/81e107e78c0f4c01abbe63f378d1c489.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/81e107e78c0f4c01abbe63f378d1c489"}}, "title": "Early experience of COVID-19 vaccination in adults with systemic rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey.", "authors": [{"family": "Sattui", "given": "Sebastian Eduardo", "initials": "SE", "orcid": "0000-0002-3945-6828", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58eb263e05ae4014897c534b20631833.json"}}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Kennedy", "given": "Kevin", "initials": "K", "orcid": "0000-0001-8230-091X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e92ad85b0e843e3b11d71e87aa1edaf.json"}}, {"family": "Sirotich", "given": "Emily", "initials": "E", "orcid": "0000-0002-7087-8543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c5dfbc359844544aa3684d916185fac.json"}}, {"family": "Putman", "given": "Michael", "initials": "M"}, {"family": "Moni", "given": "Tarin T", "initials": "TT"}, {"family": "Akpabio", "given": "Akpabio", "initials": "A", "orcid": "0000-0002-4920-6494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a237df6d34e4f7da430d8d71bc73d45.json"}}, {"family": "Alp\u00edzar-Rodr\u00edguez", "given": "Deshir\u00e9", "initials": "D", "orcid": "0000-0002-6930-0517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44724489165b403d8cb39923240c7136.json"}}, {"family": "Berenbaum", "given": "Francis", "initials": "F", "orcid": "0000-0001-8252-7815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c14dfcd19e6a40e78373f28030d22b12.json"}}, {"family": "Bulina", "given": "Inita", "initials": "I"}, {"family": "Conway", "given": "Richard", "initials": "R", "orcid": "0000-0003-2538-3362", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77fe264e6d0d4c87b734f3fa02e42c15.json"}}, {"family": "Singh", "given": "Aman Dev", "initials": "AD"}, {"family": "Duff", "given": "Eimear", "initials": "E"}, {"family": "Durrant", "given": "Karen L", "initials": "KL"}, {"family": "Gheita", "given": "Tamer A", "initials": "TA"}, {"family": "Hill", "given": "Catherine L", "initials": "CL"}, {"family": "Howard", "given": "Richard A", "initials": "RA"}, {"family": "Hoyer", "given": "Bimba F", "initials": "BF"}, {"family": "Hsieh", "given": "Evelyn", "initials": "E"}, {"family": "El Kibbi", "given": "Lina", "initials": "L"}, {"family": "Kilian", "given": "Adam", "initials": "A"}, {"family": "Kim", "given": "Alfred Hyoungju", "initials": "AH", "orcid": "0000-0003-4074-0516", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5e89146ab5d45f8b436df9ff7e279e8.json"}}, {"family": "Liew", "given": "David F L", "initials": "DFL"}, {"family": "Lo", "given": "Chieh", "initials": "C"}, {"family": "Miller", "given": "Bruce", "initials": "B"}, {"family": "Mingolla", "given": "Serena", "initials": "S"}, {"family": "Nudel", "given": "Michal", "initials": "M"}, {"family": "Palmerlee", "given": "Candace A", "initials": "CA"}, {"family": "Singh", "given": "Jasvinder A", "initials": "JA", "orcid": "0000-0003-3485-0006", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e70577b3133946d097e7e21e739b8aec.json"}}, {"family": "Singh", "given": "Namrata", "initials": "N"}, {"family": "Ugarte-Gil", "given": "Manuel Francisco", "initials": "MF", "orcid": "0000-0003-1728-1999", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b49a52ac208747ed9b85f286119da620.json"}}, {"family": "Wallace", "given": "John", "initials": "J"}, {"family": "Young", "given": "Kristen J", "initials": "KJ"}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Costello", "given": "Wendy", "initials": "W"}, {"family": "Grainger", "given": "Rebecca", "initials": "R"}, {"family": "Machado", "given": "Pedro M", "initials": "PM", "orcid": "0000-0002-8411-7972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef40d1eea57946e4a37d2e92a02a47cd.json"}}, {"family": "Robinson", "given": "Philip C", "initials": "PC", "orcid": "0000-0002-3156-3418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/950b622d31724172817ccde09902d215.json"}}, {"family": "Sufka", "given": "Paul", "initials": "P"}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Yazdany", "given": "Jinoos", "initials": "J"}, {"family": "Harrison", "given": "Carly", "initials": "C"}, {"family": "Larch\u00e9", "given": "Maggie", "initials": "M"}, {"family": "Levine", "given": "Mitchell", "initials": "M"}, {"family": "Foster", "given": "Gary", "initials": "G"}, {"family": "Thabane", "given": "Lehana", "initials": "L"}, {"family": "Rider", "given": "Lisa G", "initials": "LG"}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS", "orcid": "0000-0003-0786-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d99dc166f48d4af7b8e46dc999c7444b.json"}}, {"family": "Simard", "given": "Julia F", "initials": "JF", "orcid": "0000-0001-5735-9856", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ac28a1c6150426997d458b40c43f512.json"}}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA", "orcid": "0000-0002-5556-4618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/192552e5e3d2435799e57111ea84502d.json"}}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "RMD Open", "issn": "2056-5933", "volume": "7", "issue": "3", "issn-l": null}, "abstract": "We describe the early experiences of adults with systemic rheumatic disease who received the COVID-19 vaccine.\n\nFrom 2 April to 30 April 2021, we conducted an online, international survey of adults with systemic rheumatic disease who received COVID-19 vaccination. We collected patient-reported data on clinician communication, beliefs and intent about discontinuing disease-modifying antirheumatic drugs (DMARDs) around the time of vaccination, and patient-reported adverse events after vaccination.\n\nWe analysed 2860 adults with systemic rheumatic diseases who received COVID-19 vaccination (mean age 55.3 years, 86.7% female, 86.3% white). Types of COVID-19 vaccines were Pfizer-BioNTech (53.2%), Oxford/AstraZeneca (22.6%), Moderna (21.3%), Janssen/Johnson & Johnson (1.7%) and others (1.2%). The most common rheumatic disease was rheumatoid arthritis (42.3%), and 81.2% of respondents were on a DMARD. The majority (81.9%) reported communicating with clinicians about vaccination. Most (66.9%) were willing to temporarily discontinue DMARDs to improve vaccine efficacy, although many (44.3%) were concerned about rheumatic disease flares. After vaccination, the most reported patient-reported adverse events were fatigue/somnolence (33.4%), headache (27.7%), muscle/joint pains (22.8%) and fever/chills (19.9%). Rheumatic disease flares that required medication changes occurred in 4.6%.\n\nAmong adults with systemic rheumatic disease who received COVID-19 vaccination, patient-reported adverse events were typical of those reported in the general population. Most patients were willing to temporarily discontinue DMARDs to improve vaccine efficacy. The relatively low frequency of rheumatic disease flare requiring medications was reassuring.", "doi": "10.1136/rmdopen-2021-001814", "pmid": "34493645", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "rmdopen-2021-001814"}], "notes": [], "created": "2021-09-09T05:41:15.198Z", "modified": "2021-09-09T05:42:15.542Z"}, {"entity": "publication", "iuid": "df2cb94bee5e4e78bdb2368bb1ad1e87", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/df2cb94bee5e4e78bdb2368bb1ad1e87.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/df2cb94bee5e4e78bdb2368bb1ad1e87"}}, "title": "Dismantling internet-based cognitive behavioral therapy for tinnitus. The contribution of applied relaxation: A randomized controlled trial.", "authors": [{"family": "Beukes", "given": "Eldr\u00e9 W", "initials": "EW"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Fagelson", "given": "Marc A", "initials": "MA"}, {"family": "Manchaiah", "given": "Vinaya", "initials": "V"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Internet Interv", "issn": "2214-7829", "volume": "25", "issue": null, "pages": "100402", "issn-l": "2214-7829"}, "abstract": "Internet-based cognitive behavioral therapy (ICBT) for tinnitus is an evidence-based intervention. The components of ICBT for tinnitus have, however, not been dismantled and thus the effectiveness of the different therapeutic components is unknown. It is, furthermore, not known if heterogeneous tinnitus subgroups respond differently to ICBT.\n\nThis dismantling study aimed to explore the contribution of applied relaxation within ICBT for reducing tinnitus distress and comorbidities associated with tinnitus. A secondary aim was to assess whether outcomes varied for three tinnitus subgroups, namely those with significant tinnitus severity, those with low tinnitus severity, and those with significant depression.\n\nA parallel randomized controlled trial design ( n = 126) was used to compare audiologist-guided applied relaxation with the full ICBT intervention. Recruitment was online and via the intervention platform. Assessments were completed at four-time points including a 2-month follow-up period. The primary outcome was tinnitus severity as measured by the Tinnitus Functional Index. Secondary outcomes were included for anxiety, depression, insomnia, negative tinnitus cognitions, health-related quality of life, hearing disability, and hyperacusis. Treatment engagement variables including the number of logins, number of modules opened, and the number of messages sent. Both an intention-to-treat analysis and completer's only analysis were undertaken.\n\nEngagement was low which compromised results as the full intervention was undertaken by few participants. Both the ICBT and applied relaxation resulted in large reduction of tinnitus severity (within-group effect sizes d = 0.87 and 0.68, respectively for completers only analysis), which were maintained, or further improved at follow-up. These reductions in tinnitus distress were greater for the ICBT group, with a small effect size differences (between-group d = 0.15 in favor of ICBT for completers only analysis). Tinnitus distress decreased the most at post-intervention for those with significant depression at baseline. Both ICBT and applied relaxation contributed to significant reductions on most secondary outcome measures, with no group differences, except for a greater reduction of hyperacusis in the ICBT group.\n\nDue to poor compliance partly attributed to the COVID-19 pandemic results were compromised. Further studies employing strategies to improve compliance and engagement are required. The intervention's effectiveness increased with initial level of tinnitus distress; those with the highest scores at intake experienced the most substantial changes on the outcome measures. This may suggest tailoring of interventions according to tinnitus severity. Larger samples are needed to confirm this.", "doi": "10.1016/j.invent.2021.100402", "pmid": "34040997", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2214-7829(21)00042-7"}, {"db": "pmc", "key": "PMC8141772"}, {"db": "URL", "key": "https://doi.org/10.6084/m9.figshare.13679179", "description": "Dataset, demographic questionnaire and metadata"}], "notes": [], "created": "2021-05-29T15:31:18.566Z", "modified": "2021-11-19T10:52:32.033Z"}, {"entity": "publication", "iuid": "7952fb75226c454491af5321fd3fa6a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7952fb75226c454491af5321fd3fa6a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7952fb75226c454491af5321fd3fa6a6"}}, "title": "Development of humoral and cellular immunological memory against SARS-CoV-2 despite B cell depleting treatment in multiple sclerosis", "authors": [{"family": "Asplund H\u00f6gelin", "given": "Klara", "initials": "K"}, {"family": "Ruffin", "given": "Nicolas", "initials": "N", "orcid": "0000-0002-3698-5505", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15efeb249ce44bb0ab2bc6017d2548d0.json"}}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Gafvelin", "given": "Guro", "initials": "G"}, {"family": "Gr\u00f6nlund", "given": "Hans", "initials": "H"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Khademi", "given": "Mohsen", "initials": "M"}, {"family": "Olsson", "given": "Tomas", "initials": "T"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Al Nimer", "given": "Faiez", "initials": "F"}], "type": "journal-article", "published": "2021-09-00", "journal": {"title": "iScience", "issn": "2589-0042", "issn-l": "2589-0042", "volume": "24", "issue": "9", "pages": "103078"}, "abstract": "B cell depleting therapies (BCDTs) are widely used as immunomodulating agents for autoimmune diseases such as multiple sclerosis. Their possible impact on development of immunity to severe acute respiratory syndrome virus-2 (SARS-CoV-2) has raised concerns with the coronavirus disease 2019 (COVID-19) pandemic. We here evaluated the frequency of COVID-19-like symptoms and determined immunological responses in participants of an observational trial comprising several multiple sclerosis disease modulatory drugs (COMBAT-MS; NCT03193866) and in eleven patients after vaccination, with a focus on BCDT. Almost all seropositive and 17.9% of seronegative patients on BCDT, enriched for a history of COVID-19-like symptoms, developed anti-SARS-CoV-2 T cell memory, and T cells displayed functional similarity to controls producing IFN-\u03b3 and TNF. Following vaccination, vaccine-specific humoral memory was impaired, while all patients developed a specific T cell response. These results indicate that BCDTs do not abrogate SARS-CoV-2 cellular memory and provide a possible explanation as to why the majority of patients on BCDTs recover from COVID-19.", "doi": "10.1016/j.isci.2021.103078", "pmid": "34490414", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Vaccine": null, "Research Area: High-throughput and high-content serology": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(21)01046-4"}, {"db": "pmc", "key": "PMC8410640"}], "notes": [], "created": "2021-09-09T05:36:02.573Z", "modified": "2021-12-13T08:58:20.658Z"}, {"entity": "publication", "iuid": "cedc0f4e7276462dbce1cf4d8fdf6cf0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cedc0f4e7276462dbce1cf4d8fdf6cf0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cedc0f4e7276462dbce1cf4d8fdf6cf0"}}, "title": "Conducting a multi-country online alcohol survey in the time of the COVID-19 pandemic: Opportunities and challenges.", "authors": [{"family": "Kilian", "given": "Carolin", "initials": "C", "orcid": "0000-0001-5913-6488", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed0409bb90b346cd9001bebb46bdcf87.json"}}, {"family": "Rehm", "given": "J\u00fcrgen", "initials": "J", "orcid": "0000-0001-5665-0385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83f5b8ddf5844eb6a1118d8ec4c4dca2.json"}}, {"family": "Allebeck", "given": "Peter", "initials": "P", "orcid": "0000-0002-2778-6467", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de9f0e1c3e4d402b93e61ad1c5a771fb.json"}}, {"family": "Bart\u00e1k", "given": "Miroslav", "initials": "M", "orcid": "0000-0002-7265-6514", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77e98268e4ef42f6a5a036b75d6a1c56.json"}}, {"family": "Braddick", "given": "Fleur", "initials": "F", "orcid": "0000-0001-6755-4567", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e9df2867269470ab43dd6802b5abb49.json"}}, {"family": "Gual", "given": "Antoni", "initials": "A", "orcid": "0000-0002-7130-981X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a9b53e2b8644056920e73b5b1d014d9.json"}}, {"family": "Matrai", "given": "Silvia", "initials": "S", "orcid": "0000-0002-0308-7354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/333166e20d4e4bf99ce09910268ab080.json"}}, {"family": "Petru\u017eelka", "given": "Benjamin", "initials": "B", "orcid": "0000-0003-0318-3589", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/135b991aff2a486cb76a4f362d85b5e6.json"}}, {"family": "Rogalewicz", "given": "Vladimir", "initials": "V", "orcid": "0000-0001-5432-4148", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/904dc3953e4e42d4ac5f317f7b3c5b36.json"}}, {"family": "Rossow", "given": "Ingeborg", "initials": "I", "orcid": "0000-0001-8652-9367", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab426c14c36143d0bd2da8eb86f74e97.json"}}, {"family": "Schulte", "given": "Bernd", "initials": "B", "orcid": "0000-0003-1139-030X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79c126298bdf42518d5d0384a7e1ec42.json"}}, {"family": "\u0160telem\u0117kas", "given": "Mindaugas", "initials": "M", "orcid": "0000-0002-2040-6900", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56ebd7e17fe04fd788add93ee5c3324d.json"}}, {"family": "Manthey", "given": "Jakob", "initials": "J", "orcid": "0000-0003-1231-3760", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5e779db5bf14c38aad0f3a964b7d9bd.json"}}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Int J Methods Psychiatr Res", "issn": "1557-0657", "issn-l": null, "volume": "30", "issue": "3", "pages": "e1875"}, "abstract": "This contribution provides insights into the methodology of a pan-European population-based online survey, performed without external funding during the COVID-19 pandemic. We present the impact of different dissemination strategies to collect data from a non-probabilistic convenience sample and outline post-stratification weighting schemes, to provide guidance for future multi-country survey studies.\n\nDescription and comparison of dissemination strategies for five exemplary countries (Czechia, Germany, Lithuania, Norway, Spain) participating in the Alcohol Use and COVID-19 Survey. Comparison of the sample distribution with the country's actual population distribution according to sociodemographics, and development of weighting schemes.\n\nThe dissemination of online surveys through national newspapers, paid social media adverts and dissemination with the support of national health ministries turned out to be the most effective strategies. Monitoring the responses and adapting dissemination strategies to reach under-represented groups, and the application of sample weights were helpful to achieve an analytic sample matching the respective general population profiles.\n\nReaching a large pan-European convenience sample, including most European countries, in a short time was feasible, with the support of a broad scientific network.", "doi": "10.1002/mpr.1875", "pmid": "33951258", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8209885"}, {"db": "figshare", "key": "10.6084/m9.figshare.13580693.v1"}], "notes": [], "created": "2021-05-06T05:52:12.283Z", "modified": "2023-06-19T07:33:03.794Z"}, {"entity": "publication", "iuid": "23272de6f88949138a758530f7ceb860", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23272de6f88949138a758530f7ceb860.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23272de6f88949138a758530f7ceb860"}}, "title": "Comparable endemic coronavirus nucleoprotein-specific antibodies in mild and severe Covid-19 patients.", "authors": [{"family": "Leach", "given": "Susannah", "initials": "S", "orcid": "0000-0002-9614-2753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18d00be831d241dca238b3253d1b45f6.json"}}, {"family": "Harandi", "given": "Ali M", "initials": "AM"}, {"family": "Bergstr\u00f6m", "given": "Tomas", "initials": "T"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "van der Hoek", "given": "Lia", "initials": "L"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "J Med Virol", "issn": "1096-9071", "issn-l": null, "volume": "93", "issue": "9", "pages": "5614-5617"}, "abstract": "The severity of disease of Covid-19 is highly variable, ranging from asymptomatic to critical respiratory disease and death. Potential cross-reactive immune responses between SARS-CoV-2 and endemic coronavirus (eCoV) may hypothetically contribute to this variability. We herein studied if eCoV nucleoprotein (N)-specific antibodies in the sera of patients with mild or severe Covid-19 are associated with Covid-19 severity. There were comparable levels of eCoV N-specific antibodies early and during the first month of infection in Covid-19 patients with mild and severe symptoms, and healthy SARS-CoV-2-negative subjects. These results warrant further studies to investigate the potential role of eCoV-specific antibodies in immunity to SARS-CoV-2 infection.", "doi": "10.1002/jmv.27038", "pmid": "33913546", "labels": {"Funder: Vinnova": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC8242474"}], "notes": [], "created": "2021-04-30T04:12:21.490Z", "modified": "2021-12-12T18:08:26.325Z"}, {"entity": "publication", "iuid": "d683d834f14e47f488d2376e7e0114ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d683d834f14e47f488d2376e7e0114ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d683d834f14e47f488d2376e7e0114ca"}}, "title": "COVID-19 and Its Triangle Effects on Human's Well-Being: a Qualitative Research Method Used to Collect Appropriate Data.", "authors": [{"family": "Fatahi", "given": "Nabi", "initials": "N"}, {"family": "Kakamad", "given": "Karwan", "initials": "K"}, {"family": "Babakr", "given": "Zana", "initials": "Z"}, {"family": "Tafran", "given": "Khaled", "initials": "K"}, {"family": "\u00d8kland", "given": "\u00d8yvind", "initials": "\u00d8"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Acta Inform Med", "issn": "0353-8109", "issn-l": null, "volume": "29", "issue": "3", "pages": "197-204"}, "abstract": "The health-related challenges caused by the virus and the implications of the policies implemented to fight against it further cause psychological and socio-economic consequences that could threaten the well-being of the people.\r\n\r\nThis study has been carried out to identify people's psychosoical reactions toward COVID-19.\r\n\r\nSemi-structured interviews as a qualitative research method were used to collect data from 20 people across three countries, and content analysis was applied to interpret the data.\r\n\r\nOverall, the results indicated that COVID-19 has had negative consequences on psychological well-being of the general population. COVID-19 has forced people to maintain social distance and has led to family conflicts in some families. Moreover, COVID-19 has caused loss of jobs and mental health problems.\r\n\r\nCOVID-19 has affected people's daily life and a significant influence on individuals and society. This research demonstrates some of the ramifications in terms of psychological well-being of the general population. One of the most important findings is the importance of social life and meeting people in person, not just online. The current pandemic is influencing people's psychological well-being in a variety of ways.", "doi": "10.5455/aim.2021.29.197-204", "pmid": "34759460", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "AIM-29-197"}, {"db": "pmc", "key": "PMC8563050"}], "notes": [], "created": "2021-11-26T15:17:35.417Z", "modified": "2022-11-23T08:52:38.642Z"}, {"entity": "publication", "iuid": "cd4149ce45ee4f1f899ff2e3efacc239", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd4149ce45ee4f1f899ff2e3efacc239.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd4149ce45ee4f1f899ff2e3efacc239"}}, "title": "Antiphospholipid antibodies and neurological manifestations in acute COVID-19: A single-centre cross-sectional study.", "authors": [{"family": "Benjamin", "given": "Laura A", "initials": "LA", "orcid": "0000-0002-9685-1664", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15ffcba9a1b94d2d9d33c533c03a23d5.json"}}, {"family": "Paterson", "given": "Ross W", "initials": "RW"}, {"family": "Moll", "given": "Rachel", "initials": "R"}, {"family": "Pericleous", "given": "Charis", "initials": "C"}, {"family": "Brown", "given": "Rachel", "initials": "R"}, {"family": "Mehta", "given": "Puja R", "initials": "PR"}, {"family": "Athauda", "given": "Dilan", "initials": "D"}, {"family": "Ziff", "given": "Oliver J", "initials": "OJ"}, {"family": "Heaney", "given": "Judith", "initials": "J"}, {"family": "Checkley", "given": "Anna M", "initials": "AM"}, {"family": "Houlihan", "given": "Catherine F", "initials": "CF"}, {"family": "Chou", "given": "Michael", "initials": "M"}, {"family": "Heslegrave", "given": "Amanda J", "initials": "AJ"}, {"family": "Chandratheva", "given": "Arvind", "initials": "A"}, {"family": "Michael", "given": "Benedict D", "initials": "BD"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Vivekanandam", "given": "Vinojini", "initials": "V"}, {"family": "Foulkes", "given": "Alexander", "initials": "A"}, {"family": "Mummery", "given": "Catherine J", "initials": "CJ"}, {"family": "Lunn", "given": "Michael P", "initials": "MP"}, {"family": "Keddie", "given": "Stephen", "initials": "S"}, {"family": "Spyer", "given": "Moira J", "initials": "MJ"}, {"family": "Mckinnon", "given": "Tom", "initials": "T"}, {"family": "Hart", "given": "Melanie", "initials": "M", "orcid": "0000-0002-7396-1916", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c6e01af5c6d4e5e8fed4f1404d1ad5c.json"}}, {"family": "Carletti", "given": "Francesco", "initials": "F"}, {"family": "J\u00e4ger", "given": "Hans Rolf", "initials": "HR"}, {"family": "Manji", "given": "Hadi", "initials": "H"}, {"family": "Zandi", "given": "Michael S", "initials": "MS"}, {"family": "Werring", "given": "David J", "initials": "DJ"}, {"family": "Nastouli", "given": "Eleni", "initials": "E"}, {"family": "Simister", "given": "Robert", "initials": "R"}, {"family": "Solomon", "given": "Tom", "initials": "T"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Schott", "given": "Jonathan M", "initials": "JM"}, {"family": "Cohen", "given": "Hannah", "initials": "H"}, {"family": "Efthymiou", "given": "Maria", "initials": "M"}, {"family": "UCLH Queen Square COVID-19 Biomarker Study group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "issn-l": null, "volume": "39", "issue": null, "pages": "101070"}, "abstract": "A high prevalence of antiphospholipid antibodies has been reported in case series of patients with neurological manifestations and COVID-19; however, the pathogenicity of antiphospholipid antibodies in COVID-19 neurology remains unclear.\n\nThis single-centre cross-sectional study included 106 adult patients: 30 hospitalised COVID-neurological cases, 47 non-neurological COVID-hospitalised controls, and 29 COVID-non-hospitalised controls, recruited between March and July 2020. We evaluated nine antiphospholipid antibodies: anticardiolipin antibodies [aCL] IgA, IgM, IgG; anti-beta-2 glycoprotein-1 [a\u03b22GPI] IgA, IgM, IgG; anti-phosphatidylserine/prothrombin [aPS/PT] IgM, IgG; and anti-domain I \u03b22GPI (aD1\u03b22GPI) IgG.\n\nThere was a high prevalence of antiphospholipid antibodies in the COVID-neurological (73.3%) and non-neurological COVID-hospitalised controls (76.6%) in contrast to the COVID-non-hospitalised controls (48.2%). aPS/PT IgG titres were significantly higher in the COVID-neurological group compared to both control groups (p < 0.001). Moderate-high titre of aPS/PT IgG was found in 2 out of 3 (67%) patients with acute disseminated encephalomyelitis [ADEM]. aPS/PT IgG titres negatively correlated with oxygen requirement (FiO2 R=-0.15 p = 0.040) and was associated with venous thromboembolism (p = 0.043). In contrast, aCL IgA (p < 0.001) and IgG (p < 0.001) was associated with non-neurological COVID-hospitalised controls compared to the other groups and correlated positively with d-dimer and creatinine but negatively with FiO2.\n\nOur findings show that aPS/PT IgG is associated with COVID-19-associated ADEM. In contrast, aCL IgA and IgG are seen much more frequently in non-neurological hospitalised patients with COVID-19. Characterisation of antiphospholipid antibody persistence and potential longitudinal clinical impact are required to guide appropriate management.\n\nThis work is supported by UCL Queen Square Biomedical Research Centre (BRC) and Moorfields BRC grants (#560441 and #557595). LB is supported by a Wellcome Trust Fellowship (222102/Z/20/Z). RWP is supported by an Alzheimer's Association Clinician Scientist Fellowship (AACSF-20-685780) and the UK Dementia Research Institute. KB is supported by the Swedish Research Council (#2017-00915) and the Swedish state under the agreement between the Swedish government and the County Councils, the ALF-agreement (#ALFGBG-715986). HZ is a Wallenberg Scholar supported by grants from the Swedish Research Council (#2018-02532), the European Research Council (#681712), Swedish State Support for Clinical Research (#ALFGBG-720931), the Alzheimer Drug Discovery Foundation (ADDF), USA (#201809-2016862), and theUK Dementia Research Institute at UCL. BDM is supported by grants from the MRC/UKRI (MR/V007181/1), MRC (MR/T028750/1) and Wellcome (ISSF201902/3). MSZ, MH and RS are supported by the UCL/UCLH NIHR Biomedical Research Centre and MSZ is supported by Queen Square National Brain Appeal.", "doi": "10.1016/j.eclinm.2021.101070", "pmid": "34401683", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC8358233"}, {"db": "pii", "key": "S2589-5370(21)00350-3"}], "notes": [], "created": "2021-08-18T07:31:21.399Z", "modified": "2023-06-19T14:53:11.303Z"}, {"entity": "publication", "iuid": "dea56f4dcd0c4470b38876ee38e5d449", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dea56f4dcd0c4470b38876ee38e5d449.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dea56f4dcd0c4470b38876ee38e5d449"}}, "title": "Prognostic Significance of Chest Imaging by LUS and CT in COVID-19 Inpatients: The ECOVID Multicenter Study.", "authors": [{"family": "Tana", "given": "Claudio", "initials": "C"}, {"family": "Ricci", "given": "Fabrizio", "initials": "F"}, {"family": "Coppola", "given": "Maria Gabriella", "initials": "MG"}, {"family": "Mantini", "given": "Cesare", "initials": "C"}, {"family": "Lauretani", "given": "Fulvio", "initials": "F"}, {"family": "Campanozzi", "given": "Daniele", "initials": "D"}, {"family": "Renda", "given": "Giulia", "initials": "G"}, {"family": "Gallina", "given": "Sabina", "initials": "S"}, {"family": "Lugar\u00e1", "given": "Marina", "initials": "M"}, {"family": "Cipollone", "given": "Francesco", "initials": "F"}, {"family": "Giamberardino", "given": "Maria Adele", "initials": "MA"}, {"family": "Mucci", "given": "Luciano", "initials": "L"}], "type": "journal article", "published": "2021-08-31", "journal": {"title": "Respiration", "issn": "1423-0356", "pages": "1-10", "issn-l": null}, "abstract": "Point-of-care lung ultrasound (LUS) score is a semiquantitative score of lung damage severity. High-resolution computed tomography (HRCT) is the gold standard method to evaluate the severity of lung involvement from the novel coronavirus disease (COVID-19). Few studies have investigated the clinical significance of LUS and HRCT scores in patients with COVID-19. Therefore, the aim of this study was to evaluate the prognostic yield of LUS and of HRCT in COVID-19 patients.\n\nWe carried out a multicenter, retrospective study aimed at evaluating the prognostic yield of LUS and HRCT by exploring the survival curve of COVID-19 inpatients. LUS and chest CT scores were calculated retrospectively by 2 radiologists with >10 years of experience in chest imaging, and the decisions were reached in consensus. LUS score was calculated on the basis of the presence or not of pleural line abnormalities, B-lines, and lung consolidations. The total score (range 0-36) was obtained from the sum of the highest scores obtained in each region. CT score was calculated for each of the 5 lobes considering the anatomical extension according to the percentage parenchymal involvement. The resulting overall global semiquantitative CT score was the sum of each single lobar score and ranged from 0 (no involvement) to 25 (maximum involvement).\n\nOne hundred fifty-three COVID-19 inpatients (mean age 65 \u00b1 15 years; 65% M), including 23 (15%) in-hospital deaths for any cause over a mean follow-up of 14 days were included. Mean LUS and CT scores were 19 \u00b1 12 and 10 \u00b1 7, respectively. A strong positive linear correlation between LUS and CT scores (Pearson correlation r = 0.754; R2 = 0.568; p < 0.001) was observed. By ROC curve analysis, the optimal cut-point for mortality prediction was 20 for LUS score and 4.5 for chest CT score. According to Kaplan-Meier survival analysis, in-hospital mortality significantly increased among COVID-19 patients presenting with an LUS score \u226520 (log-rank 0.003; HR 9.87, 95% CI: 2.22-43.83) or a chest CT score \u22654.5 (HR 4.34, 95% CI: 0.97-19.41). At multivariate Cox regression analysis, LUS score was the sole independent predictor of in-hospital mortality yielding an adjusted HR of 7.42 (95% CI: 1.59-34.5).\n\nLUS score is useful to stratify the risk in COVID-19 patients, predicting those that are at high risk of mortality.", "doi": "10.1159/000518516", "pmid": "34515247", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "000518516"}], "notes": [], "created": "2021-09-20T06:32:43.318Z", "modified": "2021-09-20T06:32:43.341Z"}, {"entity": "publication", "iuid": "7ca4e632c1764964a21e57705c6ff32a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7ca4e632c1764964a21e57705c6ff32a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7ca4e632c1764964a21e57705c6ff32a"}}, "title": "Negative effects of iodine-based contrast agent on renal function in patients with moderate reduced renal function hospitalized for COVID-19.", "authors": [{"family": "Kistner", "given": "Anna", "initials": "A", "orcid": "0000-0002-7942-3211", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/833e8a08aed54e66bf271a795f93507f.json"}}, {"family": "Tamm", "given": "Chen", "initials": "C"}, {"family": "Svensson", "given": "Ann Mari", "initials": "AM"}, {"family": "Beckman", "given": "Mats O", "initials": "MO"}, {"family": "Strand", "given": "Fredrik", "initials": "F"}, {"family": "Sk\u00f6ld", "given": "Magnus", "initials": "M"}, {"family": "Nyr\u00e9n", "given": "Sven", "initials": "S"}], "type": "journal article", "published": "2021-08-31", "journal": {"title": "BMC Nephrol", "issn": "1471-2369", "volume": "22", "issue": "1", "pages": "297", "issn-l": null}, "abstract": "Kidney disease and renal failure are associated with hospital deaths in patients with COVID - 19. We aimed to test if contrast enhancement affects short-term renal function in hospitalized COVID - 19 patients.\n\nPlasma creatinine (P-creatinine) was measured on the day of computed tomography (CT) and 24 h, 48 h, and 4-10 days after CT. Contrast-enhanced (n = 142) and unenhanced (n = 24) groups were subdivided, based on estimated glomerular filtration rates (eGFR), > 60 and \u2264 60 ml/min/1.73 m2. Contrast-induced acute renal failure (CI-AKI) was defined as \u226527 \u03bcmol/L increase or a > 50% rise in P-creatinine from CT or initiation of renal replacement therapy during follow-up. Patients with renal replacement therapy were studied separately. We evaluated factors associated with a > 50% rise in P-creatinine at 48 h and at 4-10 days after contrast-enhanced CT.\n\nMedian P-creatinine at 24-48 h and days 4-10 post-CT in patients with eGFR> 60 and eGFR\u226530-60 in contrast-enhanced and unenhanced groups did not differ from basal values. CI-AKI was observed at 48 h and at 4-10 days post contrast administration in 24 and 36% (n = 5/14) of patients with eGFR\u226530-60. Corresponding figures in the eGFR> 60 contrast-enhanced CT group were 5 and 5% respectively, (p < 0.037 and p < 0.001, Pearson \u03c72 test). In the former group, four of the five patients died within 30 days. Odds ratio analysis showed that an eGFR\u226530-60 and 30-day mortality were associated with CK-AKI both at 48 h and 4-10 days after contrast-enhanced CT.\n\nPatients with COVID - 19 and eGFR\u226530-60 had a high frequency of CK-AKI at 48 h and at 4-10 days after contrast administration, which was associated with increased 30-day mortality. For patients with eGFR\u226530-60, we recommend strict indications are practiced for contrast-enhanced CT. Contrast-enhanced CT had a modest effect in patients with eGFR> 60.", "doi": "10.1186/s12882-021-02469-w", "pmid": "34465289", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12882-021-02469-w"}, {"db": "pmc", "key": "PMC8407403"}], "notes": [], "created": "2021-09-06T06:21:51.895Z", "modified": "2021-09-06T06:21:51.945Z"}, {"entity": "publication", "iuid": "1a003c7f725c4e19aeee8cb678f456ed", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1a003c7f725c4e19aeee8cb678f456ed.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1a003c7f725c4e19aeee8cb678f456ed"}}, "title": "Intermarriage and COVID-19 mortality among immigrants. A population-based cohort study from Sweden.", "authors": [{"family": "Aradhya", "given": "Siddartha", "initials": "S", "orcid": "0000-0003-3748-6270", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07f9e1a0528249a7ba6d39e2c0f3a7fe.json"}}, {"family": "Brand\u00e9n", "given": "Maria", "initials": "M"}, {"family": "Drefahl", "given": "Sven", "initials": "S"}, {"family": "Obu\u0107ina", "given": "Ognjen", "initials": "O"}, {"family": "Andersson", "given": "Gunnar", "initials": "G"}, {"family": "Rostila", "given": "Mikael", "initials": "M"}, {"family": "Mussino", "given": "Eleonora", "initials": "E"}, {"family": "Ju\u00e1rez", "given": "Sol P\u00eda", "initials": "SP", "orcid": "0000-0001-9086-7588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7cb8065d45a4969857ebbc65d01a619.json"}}], "type": "journal article", "published": "2021-08-31", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "9", "pages": "e048952"}, "abstract": "To evaluate the role of language proficiency and institutional awareness in explaining excess COVID-19 mortality among immigrants.\n\nCohort study with follow-up between 12 March 2020 and 23 February 2021.\n\nSwedish register-based study on all residents in Sweden.\n\n3 963 356 Swedish residents in co-residential unions who were 30 years of age or older and alive on 12 March 2020 and living in Sweden in December 2019.\n\nCox regression models were conducted to assess the association between different constellations of immigrant-native couples (proxy for language proficiency and institutional awareness) and COVID-19 mortality and all other causes of deaths (2019 and 2020). Models were adjusted for relevant confounders.\n\nCompared with Swedish-Swedish couples (1.18 deaths per thousand person-years), both immigrants partnered with another immigrant and a native showed excess mortality for COVID-19 (HR 1.43; 95% CI 1.29 to 1.58 and HR 1.24; 95% CI 1.10 to 1.40, respectively), which translates to 1.37 and 1.28 deaths per thousand person-years. Moreover, similar results are found for natives partnered with an immigrant (HR 1.15; 95% CI 1.02 to 1.29), which translates to 1.29 deaths per thousand person-years. Further analysis shows that immigrants from both high-income and low-income and middle-income countries (LMIC) experience excess mortality also when partnered with a Swede. However, having a Swedish-born partner is only partially protective against COVID-19 mortality among immigrants from LMIC origins.\n\nLanguage barriers and/or poor institutional awareness are not major drivers for the excess mortality from COVID-19 among immigrants. Rather, our study provides suggestive evidence that excess mortality among immigrants is explained by differential exposure to the virus.", "doi": "10.1136/bmjopen-2021-048952", "pmid": "34465581", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8413476"}, {"db": "pii", "key": "bmjopen-2021-048952"}], "notes": [], "created": "2021-09-06T06:21:38.437Z", "modified": "2023-01-13T14:42:16.876Z"}, {"entity": "publication", "iuid": "edaa9c0fdc684b87a74e9042bf94b470", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/edaa9c0fdc684b87a74e9042bf94b470.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/edaa9c0fdc684b87a74e9042bf94b470"}}, "title": "Editorial: The Different Faces of Sickness.", "authors": [{"family": "Rademacher", "given": "Lena", "initials": "L"}, {"family": "Lasselin", "given": "Julie", "initials": "J"}, {"family": "Karshikoff", "given": "Bianka", "initials": "B"}, {"family": "Hundt", "given": "Jennifer E", "initials": "JE"}, {"family": "Engler", "given": "Harald", "initials": "H"}, {"family": "Lange", "given": "Tanja", "initials": "T"}], "type": "editorial", "published": "2021-08-31", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "735337", "issn-l": "1664-0640"}, "abstract": null, "doi": "10.3389/fpsyt.2021.735337", "pmid": "34531771", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8438174"}], "notes": [], "created": "2021-09-20T16:55:00.580Z", "modified": "2021-09-20T16:55:00.590Z"}, {"entity": "publication", "iuid": "02137f9a606f465db43e1cd4d73138d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02137f9a606f465db43e1cd4d73138d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02137f9a606f465db43e1cd4d73138d0"}}, "title": "Online teaching in physiotherapy education during COVID-19 pandemic in Italy: a retrospective case-control study on students' satisfaction and performance.", "authors": [{"family": "Rossettini", "given": "Giacomo", "initials": "G"}, {"family": "Geri", "given": "Tommaso", "initials": "T"}, {"family": "Turolla", "given": "Andrea", "initials": "A"}, {"family": "Viceconti", "given": "Antonello", "initials": "A"}, {"family": "Scum\u00e0", "given": "Cristina", "initials": "C"}, {"family": "Mirandola", "given": "Mattia", "initials": "M"}, {"family": "Dell'Isola", "given": "Andrea", "initials": "A"}, {"family": "Gianola", "given": "Silvia", "initials": "S"}, {"family": "Maselli", "given": "Filippo", "initials": "F"}, {"family": "Palese", "given": "Alvisa", "initials": "A"}], "type": "journal article", "published": "2021-08-30", "journal": {"title": "BMC Med Educ", "issn": "1472-6920", "volume": "21", "issue": "1", "pages": "456", "issn-l": null}, "abstract": "During COVID-19 pandemic, physiotherapy lecturers faced the challenge of rapidly shifting from face-to-face to online education. This retrospective case-control study aims to compare students' satisfaction and performances shown in an online course to a control group of students who underwent the same course delivered face-to-face in the previous five years.\n\nBetween March and April 2020, a class (n = 46) of entry-level physiotherapy students (University of Verona - Italy), trained by an experienced physiotherapist, had 24-hours online lessons. Students exposed to the same course in the previous five academic years (n = 112), delivered with face-to-face conventional lessons, served as a historical control. The course was organized in 3 sequential phases: (1) PowerPoint presentations were uploaded to the University online platform, (2) asynchronous video recorded lectures were provided on the same platform, and (3) between online lectures, the lecturer and students could communicate through an email chat to promote understanding, dispel any doubts and collect requests for supplementary material (e.g., scientific articles, videos, webinars, podcasts). Outcomes were: (1) satisfaction as routinely measured by University with a national instrument and populated in a database; (2) performance as measured with an oral examination.\n\nWe compared satisfaction with the course, expressed on a 5-point Likert scale, resulting in no differences between online and face-to-face teaching (Kruskal-Wallis 2 = 0.24, df = 1, p = 0.62). We weighted up students' results by comparing their mean performances with the mean performances of the same course delivered face-to-face in the previous five years, founding a statistical significance in favour of online teaching (Wilcoxon rank sum test W = 1665, p < 0.001).\n\nOnline teaching in entry-level Physiotherapy seems to be a feasible option to face COVID-19 pandemic, as satisfies students as well as face-to-face courses and leading to a similar performance. Entry-level Bachelors in Physiotherapy may consider moving to eLearning to facilitate access to higher education. Universities will have to train lecturers to help them develop appropriate pedagogical skills, and supply suitable support in terms of economic, organizational, and technological issues, aimed at guaranteeing a high level of education to their students.\n\nRetrospectively registered.", "doi": "10.1186/s12909-021-02896-1", "pmid": "34455979", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12909-021-02896-1"}], "notes": [], "created": "2021-09-01T07:44:05.171Z", "modified": "2021-09-01T07:44:05.184Z"}, {"entity": "publication", "iuid": "4bd928993ccb4b7b90cfbd024fc2beb7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4bd928993ccb4b7b90cfbd024fc2beb7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4bd928993ccb4b7b90cfbd024fc2beb7"}}, "title": "Knowledge, Attitude, Practice, and Fear of COVID-19: an Online-Based Cross-cultural Study.", "authors": [{"family": "Ali", "given": "Mohammad", "initials": "M", "orcid": "0000-0002-4685-5050", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7a7159c74bd4fe0b70772c0e38aca95.json"}}, {"family": "Uddin", "given": "Zakir", "initials": "Z", "orcid": "0000-0002-3018-0327", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4943eb54590d4da59a8e90294515693f.json"}}, {"family": "Banik", "given": "Palash Chandra", "initials": "PC", "orcid": "0000-0003-2395-9049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bc92afccb2642cdab232cc1ad2713b1.json"}}, {"family": "Hegazy", "given": "Fatma A", "initials": "FA", "orcid": "0000-0001-7457-083X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0821210ae124134ba4e59520be0ef83.json"}}, {"family": "Zaman", "given": "Shamita", "initials": "S"}, {"family": "Ambia", "given": "Abu Saleh Mohammed", "initials": "ASM"}, {"family": "Siddique", "given": "Md Kaoser Bin", "initials": "MKB", "orcid": "0000-0002-0336-2694", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1514c69edd242c8adf9a56020e10e53.json"}}, {"family": "Islam", "given": "Rezoana", "initials": "R"}, {"family": "Khanam", "given": "Fatema", "initials": "F"}, {"family": "Bahalul", "given": "Sayed Mohammad", "initials": "SM"}, {"family": "Sharker", "given": "Md Ahiduzzaman", "initials": "MA"}, {"family": "Hossain", "given": "FMAkram", "initials": "F"}, {"family": "Ahsan", "given": "Gias U", "initials": "GU", "orcid": "0000-0003-0737-5940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41c88cf1b358432a89fa4817902223f6.json"}}], "type": "journal article", "published": "2021-08-30", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "pages": "1-16", "issn-l": null}, "abstract": "The study aimed to measure Knowledge, Attitude, and Practice (KAP) and fear level towards COVID-19 and explore its cross-cultural variances in knowledge by sociodemographic factors among the general population of 8 different countries over 5 continents. It was a cross-sectional online survey. This survey was conducted in April 2020 among 1296 participants using the \"Google Form\" platform. Considering the social distancing formula and pandemic situation, we collect data using popular social media networks. Univariate and bivariate analyses were used to explore the collected data on KAP, fear, and sociodemographic factors. Overall knowledge score was 9.7 \u00b1 1.7 (out of 12), and gender differences (female vs male: 9.8 \u00b1 1.6 vs 9.5 \u00b1 1.9) were significant (p = 0.008) in the bivariate analysis. Knowledge score variances were found significant in some regions by gender, marital status, and education qualification. The highest and lowest mean knowledge scores were recorded in the Middle East (10.0 \u00b1 1.7) and Europe (9.3 \u00b1 2.0). Despite having a high fear score (22.5 \u00b1 5.6 out of 35), 78.35% of respondents were positively and 81.7% in a good practice level. Fear score rankings: Middle East (1st; 23.8 \u00b1 5.5), Europe (2nd; 23.2 \u00b1 5.8), Africa (3rd; 22.7 \u00b1 5.0), South Asia (4th; 22.1 \u00b1 5.7), Oceania (5th; 21.9 \u00b1 5.8), and North America (6th; 21.7 \u00b1 5.5). Fear and knowledge were not correlated. KAP and fear variation exist among geographical regions. Gender, marital status, and education qualification are factors in knowledge variances for some regions. KAP and fear measures can help health education programs consider some sociodemographic factors and regions during an outbreak of highly contagious disease and uplift a positive attitude and good practice.\n\nThe online version contains supplementary material available at 10.1007/s11469-021-00638-4.", "doi": "10.1007/s11469-021-00638-4", "pmid": "34483782", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "638"}, {"db": "pmc", "key": "PMC8404540"}], "notes": [], "created": "2021-09-08T06:25:42.911Z", "modified": "2021-11-18T13:50:53.704Z"}, {"entity": "publication", "iuid": "e25282f83df94d9aaffc0240d8b3982f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e25282f83df94d9aaffc0240d8b3982f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e25282f83df94d9aaffc0240d8b3982f"}}, "title": "Influenza Vaccination after Myocardial Infarction: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial.", "authors": [{"family": "Fr\u00f8bert", "given": "Ole", "initials": "O"}, {"family": "G\u00f6tberg", "given": "Matthias", "initials": "M"}, {"family": "Erlinge", "given": "David", "initials": "D"}, {"family": "Akhtar", "given": "Zubair", "initials": "Z"}, {"family": "Christiansen", "given": "Evald H", "initials": "EH"}, {"family": "MacIntyre", "given": "Chandini R", "initials": "CR"}, {"family": "Oldroyd", "given": "Keith G", "initials": "KG"}, {"family": "Motovska", "given": "Zuzana", "initials": "Z"}, {"family": "Erglis", "given": "Andrejs", "initials": "A"}, {"family": "Moer", "given": "Rasmus", "initials": "R"}, {"family": "Hlinomaz", "given": "Ota", "initials": "O"}, {"family": "Jakobsen", "given": "Lars", "initials": "L"}, {"family": "Engstr\u00f8m", "given": "Thomas", "initials": "T"}, {"family": "Jensen", "given": "Lisette O", "initials": "LO"}, {"family": "Fallesen", "given": "Christian O", "initials": "CO"}, {"family": "Jensen", "given": "Svend E", "initials": "SE"}, {"family": "Anger\u00e5s", "given": "Oskar", "initials": "O"}, {"family": "Calais", "given": "Fredrik", "initials": "F"}, {"family": "K\u00e5regren", "given": "Amra", "initials": "A"}, {"family": "Lauermann", "given": "J\u00f6rg", "initials": "J"}, {"family": "Mokhtari", "given": "Arash", "initials": "A"}, {"family": "Nilsson", "given": "Johan", "initials": "J"}, {"family": "Persson", "given": "Jonas", "initials": "J"}, {"family": "Stalby", "given": "Per", "initials": "P"}, {"family": "Islam", "given": "Abu K M M", "initials": "AKMM"}, {"family": "Rahman", "given": "Afzalur", "initials": "A"}, {"family": "Malik", "given": "Fazila", "initials": "F"}, {"family": "Choudhury", "given": "Sohel", "initials": "S"}, {"family": "Collier", "given": "Timothy", "initials": "T"}, {"family": "Pocock", "given": "Stuart J", "initials": "SJ"}, {"family": "Pernow", "given": "John", "initials": "J"}], "type": "journal article", "published": "2021-08-30", "journal": {"title": "Circulation", "issn": "1524-4539", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Background: Observational and small randomized studies suggest that influenza vaccine may reduce future cardiovascular events in patients with cardiovascular disease. Methods: We conducted an investigator-initiated, randomized, double-blind trial to compare inactivated influenza vaccine with saline placebo administered shortly after myocardial infarction (MI) (99.7% of patients) or high-risk stable coronary heart disease (0.3%). The primary endpoint was the composite of all-cause death, MI, or stent thrombosis at 12 months. A hierarchical testing strategy was used for the key secondary endpoints: all-cause death, cardiovascular death, MI, and stent thrombosis. Results: Due to the Covid-19 pandemic, the data safety and monitoring board decided to halt the trial before attaining the prespecified sample size. Between October 1, 2016, and March 1, 2020, 2571 participants were randomized at 30 centers across eight countries; 1290 assigned to influenza vaccine and 1281 to placebo. Over the 12-month follow-up, the primary outcome occurred in 67 participants (5.3%) assigned influenza vaccine and 91 participants (7.2%) assigned placebo (hazard ratio, 0.72; 95% confidence interval, 0.52 to 0.99; P=0.040). Rates of all-cause death were 2.9% and 4.9% (hazard ratio, 0.59; 0.39 to 0.89; P=0.010), of cardiovascular death 2.7% and 4.5%, (hazard ratio, 0.59; 0.39 to 0.90; P=0.014), and of MI 2.0% and 2.4% (hazard ratio, 0.86; 0.50 to 1.46, P=0.57) in the influenza vaccine and placebo groups, respectively. Conclusions: Influenza vaccination early after an MI or in high-risk coronary heart disease resulted in a lower risk of a composite of all-cause death, MI, or stent thrombosis, as well as a lower risk of all-cause death and cardiovascular death at 12 months compared with placebo. Clinical Trial Registration: URL: http://www.clinicaltrials.gov Unique identifier: NCT02831608.", "doi": "10.1161/CIRCULATIONAHA.121.057042", "pmid": "34459211", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT02831608"}], "notes": [], "created": "2021-09-06T15:50:59.276Z", "modified": "2021-09-06T15:51:55.770Z"}, {"entity": "publication", "iuid": "b8ae0a7929a94a8591dce0de9bd1a1bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8ae0a7929a94a8591dce0de9bd1a1bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8ae0a7929a94a8591dce0de9bd1a1bd"}}, "title": "Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopes.", "authors": [{"family": "Gattinger", "given": "Pia", "initials": "P"}, {"family": "Niespodziana", "given": "Katarzyna", "initials": "K"}, {"family": "Stiasny", "given": "Karin", "initials": "K"}, {"family": "Sahanic", "given": "Sabina", "initials": "S"}, {"family": "Tulaeva", "given": "Inna", "initials": "I"}, {"family": "Borochova", "given": "Kristina", "initials": "K"}, {"family": "Dorofeeva", "given": "Yulia", "initials": "Y"}, {"family": "Schlederer", "given": "Thomas", "initials": "T"}, {"family": "Sonnweber", "given": "Thomas", "initials": "T"}, {"family": "Hofer", "given": "Gerhard", "initials": "G"}, {"family": "Kiss", "given": "Renata", "initials": "R"}, {"family": "Kratzer", "given": "Bernhard", "initials": "B"}, {"family": "Trapin", "given": "Doris", "initials": "D"}, {"family": "Tauber", "given": "Peter A", "initials": "PA"}, {"family": "Rottal", "given": "Arno", "initials": "A"}, {"family": "K\u00f6rm\u00f6czi", "given": "Ulrike", "initials": "U"}, {"family": "Feichter", "given": "Melanie", "initials": "M"}, {"family": "Weber", "given": "Milena", "initials": "M"}, {"family": "Focke-Tejkl", "given": "Margarete", "initials": "M"}, {"family": "L\u00f6ffler-Ragg", "given": "Judith", "initials": "J"}, {"family": "M\u00fchl", "given": "Bernhard", "initials": "B"}, {"family": "Kropfm\u00fcller", "given": "Anna", "initials": "A"}, {"family": "Keller", "given": "Walter", "initials": "W"}, {"family": "Stolz", "given": "Frank", "initials": "F"}, {"family": "Henning", "given": "Rainer", "initials": "R"}, {"family": "Tancevski", "given": "Ivan", "initials": "I"}, {"family": "Puchhammer-St\u00f6ckl", "given": "Elisabeth", "initials": "E"}, {"family": "Pickl", "given": "Winfried F", "initials": "WF"}, {"family": "Valenta", "given": "Rudolf", "initials": "R"}], "type": "journal article", "published": "2021-08-28", "journal": {"title": "Allergy", "issn": "1398-9995", "issn-l": "0105-4538", "volume": null, "issue": null, "pages": null}, "abstract": "The determinants of successful humoral immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of critical importance for the design of effective vaccines and the evaluation of the degree of protective immunity conferred by exposure to the virus. As novel variants emerge, understanding their likelihood of suppression by population antibody repertoires has become increasingly important.\r\n\r\nIn this study we analysed the SARS-CoV-2 polyclonal antibody response in a large population of clinically well-characterized patients after mild and severe COVID-19 using a panel of microarrayed structurally folded and unfolded SARS-CoV-2 proteins, as well as sequential peptides, spanning the surface spike protein (S) and the receptor-binding domain (RBD) of the virus.\r\n\r\nS- and RBD-specific antibody responses were dominated by immunoglobulin G (IgG), mainly IgG1 , and directed against structurally folded S and RBD and three distinct peptide epitopes in S2. The virus-neutralization activity of patients\u00b4 sera was highly correlated with IgG antibodies specific for conformational but not sequential RBD epitopes and their ability to prevent RBD binding to its human receptor angiotensin-converting enzyme 2 (ACE2). Twenty percent of patients selectively lacked RBD-specific IgG. Only immunisation with folded, but not with unfolded RBD, induced antibodies against conformational epitopes with high virus-neutralizing activity. Conformational RBD epitopes required for protection do not seem to be altered in the currently emerging virus variants.\r\n\r\nThese results are fundamental for estimating the protective activity of antibody responses after natural infection or vaccination and for the design of vaccines, which can induce high levels of SARS-CoV-2-neutralizing antibodies conferring sterilizing immunity.", "doi": "10.1111/all.15066", "pmid": "34453317", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-09-01T07:34:03.895Z", "modified": "2021-09-01T07:35:00.011Z"}, {"entity": "publication", "iuid": "4720c066c4634d349e89e6e2482949e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4720c066c4634d349e89e6e2482949e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4720c066c4634d349e89e6e2482949e8"}}, "title": "Landscape of T-cell repertoires with public COVID-19-associated T-cell receptors in pre-pandemic risk cohorts.", "authors": [{"family": "Simnica", "given": "Donjete", "initials": "D", "orcid": "0000-0003-2286-1381", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ba6674f733f45a19f092396b7134252.json"}}, {"family": "Schulthei\u00df", "given": "Christoph", "initials": "C", "orcid": "0000-0001-9789-5776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88027bf0a4314e958d8bcf7016d8ddfc.json"}}, {"family": "Mohme", "given": "Malte", "initials": "M"}, {"family": "Paschold", "given": "Lisa", "initials": "L"}, {"family": "Willscher", "given": "Edith", "initials": "E"}, {"family": "Fitzek", "given": "Antonia", "initials": "A"}, {"family": "P\u00fcschel", "given": "Klaus", "initials": "K"}, {"family": "Matschke", "given": "Jakob", "initials": "J"}, {"family": "Ciesek", "given": "Sandra", "initials": "S"}, {"family": "Sedding", "given": "Daniel G", "initials": "DG"}, {"family": "Zhao", "given": "Yu", "initials": "Y", "orcid": "0000-0003-2632-7530", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c46abe67678044d88ed9313bb26819fe.json"}}, {"family": "Gagliani", "given": "Nicola", "initials": "N"}, {"family": "Maringer", "given": "Yacine", "initials": "Y"}, {"family": "Walz", "given": "Juliane S", "initials": "JS"}, {"family": "Heide", "given": "Janna", "initials": "J"}, {"family": "Schulze-Zur-Wiesch", "given": "Julian", "initials": "J"}, {"family": "Binder", "given": "Mascha", "initials": "M"}], "type": "journal article", "published": "2021-08-28", "journal": {"title": "Clin Transl Immunol", "issn": "2050-0068", "volume": "10", "issue": "9", "pages": "e1340", "issn-l": null}, "abstract": "T cells have an essential role in the antiviral defence. Public T-cell receptor (TCR) clonotypes are expanded in a substantial proportion of COVID-19 patients. We set out to exploit their potential use as read-out for COVID-19 T-cell immune responses.\n\nWe searched for COVID-19-associated T-cell clones with public TCRs, as defined by identical complementarity-determining region 3 (CDR3) beta chain amino acid sequence that can be reproducibly detected in the blood of COVID-19 patients. Of the different clonotype identification algorithms used in this study, deep sequencing of brain tissue of five patients with fatal COVID-19 delivered 68 TCR clonotypes with superior representation across 140 immune repertoires of unrelated COVID-19 patients.\n\nMining of immune repertoires from subjects not previously exposed to the virus showed that these clonotypes can be found in almost 20% of pre-pandemic immune repertoires of healthy subjects, with lower representation in repertoires from risk groups like individuals above the age of 60 years or patients with cancer.\n\nTogether, our data show that at least a proportion of the SARS-CoV-2 T-cell response is mediated by public TCRs that are present in repertoires of unexposed individuals. The lower representation of these clones in repertoires of risk groups or failure to expand such clones may contribute to more unfavorable clinical COVID-19 courses.", "doi": "10.1002/cti2.1340", "pmid": "34484739", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "CTI21340"}, {"db": "pmc", "key": "PMC8401425"}, {"db": "URL", "key": "https://gateway.ireceptor.org", "description": "AIRR-seq data (iReceptor Study ID IR-Binder-000001)"}, {"db": "URL", "key": "https://www.ebi.ac.uk/ena/browser/view/PRJEB38339?show=reads", "description": "Sequence data in ENA (Project: PRJEB38339)"}], "notes": [], "created": "2021-09-08T06:33:45.029Z", "modified": "2021-09-09T07:17:55.696Z"}, {"entity": "publication", "iuid": "527e3f4b97ac4d2b9894a63183be6e57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/527e3f4b97ac4d2b9894a63183be6e57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/527e3f4b97ac4d2b9894a63183be6e57"}}, "title": "\"We Thought We Were Prepared, but We Were Not\": Experiences from the Management of the Psychosocial Support Response during the COVID-19 Pandemic in Sweden. A Mixed-Methods Study.", "authors": [{"family": "Hugelius", "given": "Karin", "initials": "K", "orcid": "0000-0003-0534-4593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f7d4e9ff0f645598a2473e42806066a.json"}}, {"family": "Johansson", "given": "Sara", "initials": "S"}, {"family": "Sj\u00f6lin", "given": "Helena", "initials": "H"}], "type": "journal article", "published": "2021-08-28", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "17", "pages": null}, "abstract": "This study aimed to describe experiences of managing mental health and psychosocial activities during the first six months of the COVID-19 pandemic in Sweden. A national survey was answered by a non-probability sample of 340 involved in the psychosocial response. The psychosocial response operations met several challenges, mainly related to the diverse actors involved, lack of competence, and lack of preparations. Less than 20% of the participants had received specific training in the provision of psychosocial support during major incidents. The interventions used varied, and no large-scale interventions were used. The psychosocial response organizations were overwhelmed by the needs of health care staff and failed to meet the needs of patients and family members. An efficient and durable psychosocial response in a long-term crisis requires to be structured, planned and well-integrated into the overall pandemic response. All personnel involved need adequate and specific competence in evidence-based individual and large-scale interventions to provide psychosocial support in significant incidents. By increasing general awareness of mental wellbeing and psychosocial support amongst health professionals and their first-line managers, a more resilient health care system, both in everyday life and during major incidents and disasters, could be facilitated.", "doi": "10.3390/ijerph18179079", "pmid": "34501668", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph18179079"}], "notes": [], "created": "2021-09-13T06:08:21.348Z", "modified": "2021-11-18T13:49:38.010Z"}, {"entity": "publication", "iuid": "e707bb01f3554d2fa9ef5b495830bdad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e707bb01f3554d2fa9ef5b495830bdad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e707bb01f3554d2fa9ef5b495830bdad"}}, "title": "The clinical association between Periodontitis and COVID-19.", "authors": [{"family": "Gupta", "given": "Shipra", "initials": "S", "orcid": "0000-0003-2097-2459", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa6dd4cea3824827b3ead550b8267b2a.json"}}, {"family": "Mohindra", "given": "Ritin", "initials": "R"}, {"family": "Singla", "given": "Mohita", "initials": "M"}, {"family": "Khera", "given": "Sagar", "initials": "S"}, {"family": "Sahni", "given": "Vaibhav", "initials": "V"}, {"family": "Kanta", "given": "Poonam", "initials": "P"}, {"family": "Soni", "given": "Roop Kishor", "initials": "RK"}, {"family": "Kumar", "given": "Amit", "initials": "A"}, {"family": "Gauba", "given": "Krishan", "initials": "K"}, {"family": "Goyal", "given": "Kapil", "initials": "K"}, {"family": "Singh", "given": "Mini P", "initials": "MP"}, {"family": "Ghosh", "given": "Arnab", "initials": "A"}, {"family": "Kajal", "given": "Kamal", "initials": "K"}, {"family": "Mahajan", "given": "Varun", "initials": "V"}, {"family": "Bhalla", "given": "Ashish", "initials": "A"}, {"family": "Sorsa", "given": "Timo", "initials": "T"}, {"family": "R\u00e4is\u00e4nen", "given": "Ismo", "initials": "I"}], "type": "journal article", "published": "2021-08-27", "journal": {"title": "Clin Oral Investig", "issn": "1436-3771", "issn-l": null}, "abstract": "The study aimed to clinically assess the association between periodontitis and COVID-19-related outcomes.\n\nData pertaining to patient demographics, medical history, blood parameters, periodontal clinical examination and aMMP-8 point-of-care diagnostics (both site-level and patient-level) was recorded for eighty-two COVID-19-positive patients. COVID-19-related outcomes such as COVID-19 pneumonia, death/survival, types of hospital admission and need of assisted ventilation were also assessed.\n\nMales were predominantly afflicted with COVID-19, with advanced age exhibiting a greater association with the presence of periodontitis. Higher severity of periodontitis led to 7.45 odds of requiring assisted ventilation, 36.52 odds of hospital admission, 14.58 odds of being deceased and 4.42 odds of COVID-19-related pneumonia. The aMMP-8 mouthrinse kit was slightly more sensitive but less specific than aMMP-8 site-specific tests.\n\nBased on the findings of the present study, periodontitis seems to be related to poorer COVID-19-related outcomes. However, within the constraints of this work, a direct causality may not be established. Periodontitis, by means of skewing the systemic condition for a number of comorbidities, may eventually influence COVID-19 outcomes in an indirect manner.\n\nThe study is the first to clinically, and by means of a validated point-of-care diagnostic methodology, assess the association between periodontal health and COVID-19-related outcomes. Assessment of the periodontal status of individuals can aid in the identification of risk groups during the pandemic along with reinforcing the need to maintain oral hygiene and seeking periodontal care.", "doi": "10.1007/s00784-021-04111-3", "pmid": "34448073", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00784-021-04111-3"}, {"db": "pmc", "key": "PMC8390180"}], "notes": [], "created": "2021-09-01T07:29:31.641Z", "modified": "2021-09-01T07:29:31.688Z"}, {"entity": "publication", "iuid": "064027b6251c4ed792919419795510de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/064027b6251c4ed792919419795510de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/064027b6251c4ed792919419795510de"}}, "title": "SARS-CoV-2 Antibody Isotypes in Systemic Lupus Erythematosus Patients Prior to Vaccination: Associations With Disease Activity, Antinuclear Antibodies, and Immunomodulatory Drugs During the First Year of the Pandemic.", "authors": [{"family": "Sj\u00f6wall", "given": "Johanna", "initials": "J"}, {"family": "Azharuddin", "given": "Mohammad", "initials": "M"}, {"family": "Frodlund", "given": "Martina", "initials": "M"}, {"family": "Zhang", "given": "Yuming", "initials": "Y"}, {"family": "Sandner", "given": "Laura", "initials": "L"}, {"family": "Dahle", "given": "Charlotte", "initials": "C"}, {"family": "Hinkula", "given": "Jorma", "initials": "J"}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C"}], "type": "journal article", "published": "2021-08-27", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "12", "pages": "724047", "issn-l": "1664-3224"}, "abstract": "Impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic on individuals with arthritis has been highlighted whereas data on other rheumatic diseases, e.g., systemic lupus erythematosus (SLE), are scarce. Similarly to SLE, severe SARS-CoV-2 infection includes risks for thromboembolism, an unbalanced type I interferon response, and complement activation. Herein, SARS-CoV-2 antibodies in longitudinal samples collected prior to vaccination were analyzed and compared with SLE progression and antinuclear antibody (ANA) levels.\n\nOne hundred patients (83 women) with established SLE and a regular visit to the rheumatologist (March 2020 to January 2021) were included. All subjects donated blood and had done likewise prior to the pandemic. SARS-CoV-2 antibody isotypes (IgG, IgA, IgM) to the cell receptor-binding S1-spike outer envelope protein were detected by ELISA, and their neutralizing capacity was investigated. IgG-ANA were measured by multiplex technology.\n\nDuring the pandemic, 4% had PCR-confirmed infection but 36% showed SARS-CoV-2 antibodies of \u22651 isotype; IgA was the most common (30%), followed by IgM (9%) and IgG (8%). The antibodies had low neutralizing capacity and were detected also in prepandemic samples. Plasma albumin (p = 0.04) and anti-dsDNA (p = 0.003) levels were lower in patients with SARS-CoV-2 antibodies. Blood group, BMI, smoking habits, complement proteins, daily glucocorticoid dose, use of hydroxychloroquine, or self-reported coronavirus disease 2019 (COVID-19) symptoms (except fever, >38.5\u00b0C) did not associate with SARS-CoV-2 antibodies.\n\nOur data from early 2021 indicate that a large proportion of Swedish SLE patients had serological signs of exposure to SARS-CoV-2 but apparently with a minor impact on the SLE course. Use of steroids and hydroxychloroquine showed no distinct effects, and self-reported COVID-19-related symptoms correlated poorly with all antibody isotypes.", "doi": "10.3389/fimmu.2021.724047", "pmid": "34512651", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8430325"}], "notes": [], "created": "2021-09-20T06:34:23.895Z", "modified": "2023-06-19T15:35:17.591Z"}, {"entity": "publication", "iuid": "99548417cab34ceeb2290d9011bc64f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/99548417cab34ceeb2290d9011bc64f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/99548417cab34ceeb2290d9011bc64f4"}}, "title": "Post-traumatic stress disorder (PTSD) in parents of children with type 1 diabetes during Covid-19 pandemic.", "authors": [{"family": "Carducci", "given": "C", "initials": "C"}, {"family": "Rapini", "given": "N", "initials": "N"}, {"family": "Deodati", "given": "A", "initials": "A"}, {"family": "Pampanini", "given": "V", "initials": "V"}, {"family": "Cianfarani", "given": "S", "initials": "S"}, {"family": "Schiaffini", "given": "R", "initials": "R", "orcid": "0000-0002-9527-2353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5246b36ef614d9fb2ceb112e0cd80ba.json"}}], "type": "journal article", "published": "2021-08-26", "journal": {"title": "Ital J Pediatr", "issn": "1824-7288", "issn-l": null, "volume": "47", "issue": "1", "pages": "176"}, "abstract": "The Post-traumatic Stress Disorder (PTSD) is a group of persistent psychological and physiological symptoms due to a traumatic, severe, event. Only few studies focused on the effects of Covid-19 on psychosocial outcomes in children with Type 1 Diabetes (T1D) and their parents.\r\n\r\nThe aim of this study was to evaluate the presence PTSD in parents of children with T1D during COVID-19 pandemic lockdown.\r\n\r\nIn the period between March and May 2020 we submitted the \"Impact of Event Scale - Revised\" (IES-R) questionnaire to the parents of 34 children with Type 1 Diabetes, asking them to express their emotions about the ongoing Covid-19 pandemic.\r\n\r\nA total of thirty mothers (mean age 43.0 \u00b1 4.2 years) and 25 fathers (mean age 45.6 \u00b1 5.9 years) participated in the survey and completed the questionnaires. 29.1% of parents had a score that allows to define a clinically relevant level of PTSD; ten mothers and 6 fathers had a PTSD clinically relevant score, corresponding, respectively, to 28.4 and 24% of total mothers and fathers. Finally, mothers and fathers, both express PTSD symptoms mainly in the form of intrusion and hyperarousal.\r\n\r\nThe present study confirms a high prevalence symptoms related to PTSD in mothers and fathers of children with Type 1 Diabetes. We believe that psychosocial outcomes of the COVID-19 pandemic should be taken into account in the planning of the next future assistance for children with T1D.", "doi": "10.1186/s13052-021-01126-0", "pmid": "34446073", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13052-021-01126-0"}, {"db": "pmc", "key": "PMC8390018"}], "notes": [], "created": "2021-09-01T07:28:55.218Z", "modified": "2021-11-18T13:41:46.716Z"}, {"entity": "publication", "iuid": "47162541ac884a13b88bd4f57d46d617", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47162541ac884a13b88bd4f57d46d617.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47162541ac884a13b88bd4f57d46d617"}}, "title": "Evening-types show highest increase of sleep and mental health problems during the COVID-19 pandemic - Multinational study on 19,267 adults.", "authors": [{"family": "Merikanto", "given": "Ilona", "initials": "I", "orcid": "0000-0002-1222-6678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50ed32f3146e4c0aa13e934d46eeb4af.json"}}, {"family": "Kortesoja", "given": "Laura", "initials": "L"}, {"family": "Benedict", "given": "Christian", "initials": "C", "orcid": "0000-0002-8911-4068", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a61aee14ada46ce968c40c652ac72df.json"}}, {"family": "Chung", "given": "Frances", "initials": "F"}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J"}, {"family": "Espie", "given": "Colin A", "initials": "CA"}, {"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y", "orcid": "0000-0003-0683-6506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/630f66dea3ce4ff2afe3c46f7827355b.json"}}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L", "orcid": "0000-0003-3613-6631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e700e607f114414dba66aa366e3158b6.json"}}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK"}, {"family": "Chan", "given": "Ngan Yin", "initials": "NY"}, {"family": "Inoue", "given": "Yuichi", "initials": "Y"}, {"family": "Matsui", "given": "Kentaro", "initials": "K"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Plazzi", "given": "Giuseppe", "initials": "G"}, {"family": "Mota-Rolim", "given": "S\u00e9rgio Arthuro", "initials": "SA"}, {"family": "Leger", "given": "Damien", "initials": "D"}, {"family": "Penzel", "given": "Thomas", "initials": "T", "orcid": "0000-0002-4304-0112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0dc4e472c71460ab792f74bc8163a9a.json"}}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}], "type": "journal article", "published": "2021-08-25", "journal": {"issn": "1550-9109", "title": "Sleep", "issn-l": null}, "abstract": "Individual circadian type is a ubiquitous trait defining sleep, with eveningness often associated with poorer sleep and mental health than morningness. However, it is unknown whether COVID-19 pandemic has differentially affected sleep and mental health depending on the circadian type. Here, the differences in sleep and mental health between circadian types are examined globally before and during the COVID-19 pandemic.\n\nThe sample collected between May and August 2020 across 12 countries/regions consisted of 19,267 adults with information on their circadian type. Statistical analyses were performed by using Complex Sample procedures, stratified by country and weighted by the number of inhabitants in the country/area of interest and by the relative number of responders in that country/area.\n\nEvening-types had poorer mental health, well-being, and quality of life or health than other circadian types during the pandemic. Sleep-wake schedules were delayed especially on working days, and evening-types reported an increase in sleep duration. Sleep problems increased in all circadian types, but especially among evening-types, moderated by financial suffering and confinement. Intermediate-types were less vulnerable to sleep changes, although morningness protected from most sleep problems. These findings were confirmed after adjusting for age, sex, duration of the confinement or socio-economic status during the pandemic.\n\nThese findings indicate an alarming increase in sleep and mental health problems, especially among evening-types as compared to other circadian types during the pandemic.", "doi": "10.1093/sleep/zsab216", "pmid": "34432058", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6357297"}], "notes": [], "created": "2021-08-27T09:36:22.035Z", "modified": "2021-09-01T07:19:56.356Z"}, {"entity": "publication", "iuid": "70f55448c66a4a86b18adc2a11d6b260", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70f55448c66a4a86b18adc2a11d6b260.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70f55448c66a4a86b18adc2a11d6b260"}}, "title": "Testing indicators to monitor the COVID-19 pandemic.", "authors": [{"family": "Beaut\u00e9", "given": "Julien", "initials": "J"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "Spiteri", "given": "Gianfranco", "initials": "G"}], "type": "journal article", "published": "2021-08-24", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "issn-l": null}, "abstract": null, "doi": "10.1016/S1473-3099(21)00461-8", "pmid": "34450053", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(21)00461-8"}, {"db": "pmc", "key": "PMC8384351"}], "notes": [], "created": "2021-09-01T07:31:54.529Z", "modified": "2021-09-01T07:32:45.430Z"}, {"entity": "publication", "iuid": "7720ddb00d1f45708a974b7bb249483f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7720ddb00d1f45708a974b7bb249483f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7720ddb00d1f45708a974b7bb249483f"}}, "title": "Skin Exposures, Hand Eczema and Facial Skin Disease in Healthcare Workers During the COVID-19 Pandemic: A Cross-sectional Study.", "authors": [{"family": "Hamnerius", "given": "Nils", "initials": "N"}, {"family": "Pont\u00e9n", "given": "Ann", "initials": "A"}, {"family": "Bergendorff", "given": "Ola", "initials": "O"}, {"family": "Bruze", "given": "Magnus", "initials": "M"}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}, {"family": "Svedman", "given": "Cecilia", "initials": "C"}], "type": "journal article", "published": "2021-08-24", "journal": {"title": "Acta Derm Venereol", "issn": "1651-2057", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic has led to enhanced hygiene procedures and use of personal protective equipment, but also to increased attention to occupational skin disease in healthcare workers. The occurrence of hand and facial skin disease in > 5,000 Swedish healthcare workers was investigated in a questionnaire survey. Levels of skin exposure related to hygiene procedures and personal protective equipment were recorded. Caring for patients with COVID-19 entailed higher levels of wet work and face mask exposures, and was associated with higher 1-year prevalence of both hand eczema (36%) and facial skin disease (32%) compared with not being directly engaged in COVID-19 care (28% and 22%, respectively). Acne and eczema were the most common facial skin diseases; for both, a dose-dependent association with face mask use was found. Dose-dependent associations could be shown between hand eczema and exposure to soap and gloves, but not to alcohol-based hand disinfectants.", "doi": "10.2340/00015555-3904", "pmid": "34427318", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-27T09:37:42.140Z", "modified": "2021-09-01T07:23:18.951Z"}, {"entity": "publication", "iuid": "b1018af9509f47b19a78984fd97f69b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1018af9509f47b19a78984fd97f69b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1018af9509f47b19a78984fd97f69b2"}}, "title": "Editorial: Coronavirus Disease (COVID-19): The Impact and Role of Mass Media During the Pandemic.", "authors": [{"family": "Arriaga", "given": "Patr\u00edcia", "initials": "P"}, {"family": "Esteves", "given": "Francisco", "initials": "F"}, {"family": "Pavlova", "given": "Marina A", "initials": "MA"}, {"family": "Pi\u00e7arra", "given": "Nuno", "initials": "N"}], "type": "editorial", "published": "2021-08-23", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "729238", "issn-l": "1664-1078"}, "abstract": null, "doi": "10.3389/fpsyg.2021.729238", "pmid": "34497569", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8419265"}], "notes": [], "created": "2021-09-13T06:07:06.587Z", "modified": "2021-09-13T06:07:06.599Z"}, {"entity": "publication", "iuid": "63efea786d524e588aa3cca55dc76b1a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63efea786d524e588aa3cca55dc76b1a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63efea786d524e588aa3cca55dc76b1a"}}, "title": "Suicide by gender and 10-year age groups during the COVID-19 pandemic vs previous five years in Japan: An analysis of national vital statistics.", "authors": [{"family": "Eguchi", "given": "Akifumi", "initials": "A"}, {"family": "Nomura", "given": "Shuhei", "initials": "S"}, {"family": "Gilmour", "given": "Stuart", "initials": "S"}, {"family": "Harada", "given": "Nahoko", "initials": "N"}, {"family": "Sakamoto", "given": "Haruka", "initials": "H"}, {"family": "Ueda", "given": "Peter", "initials": "P"}, {"family": "Yoneoka", "given": "Daisuke", "initials": "D"}, {"family": "Tanoue", "given": "Yuta", "initials": "Y"}, {"family": "Kawashima", "given": "Takayuki", "initials": "T"}, {"family": "Hayashi", "given": "Takehiko I", "initials": "TI"}, {"family": "Arima", "given": "Yuzo", "initials": "Y"}, {"family": "Suzuki", "given": "Motoi", "initials": "M"}, {"family": "Hashizume", "given": "Masahiro", "initials": "M"}], "type": "journal article", "published": "2021-08-21", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "issn-l": null, "volume": "305", "issue": null, "pages": "114173"}, "abstract": "Using daily vital statistics data from the Japanese Ministry of Health, Labour and Welfare, we provide the first weekly and age-group-specific estimates of the additional suicide burden during the COVID-19 pandemic in Japan by gender, from January through November 2020. Our results indicate that compared with the previous five years, suicide cases in 2020 in Japan have increased from late July to November for women in all age groups and for men in the 20-29 and 80+ years age group. Targeted interventions based on age and gender might be more effective in reducing suicide during the COVID-19 pandemic in Japan.", "doi": "10.1016/j.psychres.2021.114173", "pmid": "34469804", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(21)00469-8"}], "notes": [], "created": "2021-09-06T06:18:57.351Z", "modified": "2022-11-23T08:53:26.049Z"}, {"entity": "publication", "iuid": "faf9cbc5033b47729c3640abd68177d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/faf9cbc5033b47729c3640abd68177d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/faf9cbc5033b47729c3640abd68177d9"}}, "title": "Internet-based stress recovery intervention FOREST for healthcare staff amid COVID-19 pandemic: study protocol for a randomized controlled trial.", "authors": [{"family": "Jovarauskaite", "given": "Lina", "initials": "L", "orcid": "0000-0002-8043-3003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d280b0d3947b4fb692053a571e4c593f.json"}}, {"family": "Dumarkaite", "given": "Austeja", "initials": "A"}, {"family": "Truskauskaite-Kuneviciene", "given": "Inga", "initials": "I"}, {"family": "Jovaisiene", "given": "Ieva", "initials": "I"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Kazlauskas", "given": "Evaldas", "initials": "E"}], "type": "clinical trial protocol", "published": "2021-08-21", "journal": {"title": "Trials", "issn": "1745-6215", "issn-l": null, "volume": "22", "issue": "1", "pages": "559"}, "abstract": "The demand for care during the COVID-19 pandemic has affected the mental health of healthcare workers (HCWs), thus increasing the need for psychosocial support services. Internet-based interventions have previously been found to reduce occupational stress. The study aims to test the effects of an Internet-based stress recovery intervention-FOREST-among HCWs.\r\n\r\nA randomized controlled trial (RCT) parallel group design with three measurement points will be conducted to assess the efficacy of an Internet-based stress recovery intervention FOREST for nurses. The FOREST intervention is a 6-week Internet-based CBT and mindfulness-based program which comprises of six modules: (1) Introduction, (2) Detachment (relaxation and sleep), (3) Distancing, (4) Mastery (challenge), (5) Control, and (6) Keeping the change alive. We will compare the intervention against a waiting list group at pre-test, post-test, and follow-up. Stress recovery, PTSD, complex PTSD, moral injury, the level of stress, depression, anxiety, and psychological well-being will be measured.\r\n\r\nThe study will contribute to the development of mental healthcare programs for the HCWs. Based on the outcomes of the study, the FOREST intervention can be further developed or offered to healthcare staff as a tool to cope with occupational stress.\r\n\r\nClinicalTrials.gov NCT04817995 . Registered on 30 March 2021.", "doi": "10.1186/s13063-021-05512-1", "pmid": "34419114", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13063-021-05512-1"}, {"db": "pmc", "key": "PMC8380103"}, {"db": "ClinicalTrials.gov", "key": "NCT04817995"}], "notes": [], "created": "2021-08-27T09:43:36.718Z", "modified": "2021-11-18T13:40:03.339Z"}, {"entity": "publication", "iuid": "21a5b0f2d8f14c15adaef521bb5ffb75", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/21a5b0f2d8f14c15adaef521bb5ffb75.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/21a5b0f2d8f14c15adaef521bb5ffb75"}}, "title": "A Global Survey of Emergency Department Responses to the COVID-19 Pandemic.", "authors": [{"family": "Mahajan", "given": "Prashant", "initials": "P"}, {"family": "Shu-Ling", "given": "Chong", "initials": "C"}, {"family": "Gutierrez", "given": "Camilo", "initials": "C"}, {"family": "White", "given": "Emily", "initials": "E"}, {"family": "Cher", "given": "Benjamin A Y", "initials": "BAY"}, {"family": "Freiheit", "given": "Elizabeth", "initials": "E"}, {"family": "Belle", "given": "Apoorva", "initials": "A"}, {"family": "EMERGE NETWORK", "given": "", "initials": ""}, {"family": "Kaartinen", "given": "Johanna", "initials": "J"}, {"family": "Kumar", "given": "Vijaya Arun", "initials": "VA"}, {"family": "Middleton", "given": "Paul M", "initials": "PM"}, {"family": "Ng", "given": "Chip Jin", "initials": "CJ"}, {"family": "Osei-Kwame", "given": "Daniel", "initials": "D"}, {"family": "Roth", "given": "Dominik", "initials": "D"}, {"family": "Sinja", "given": "Tej Prakash", "initials": "TP"}, {"family": "Galwankar", "given": "Sagar", "initials": "S"}, {"family": "Nypaver", "given": "Michele", "initials": "M"}, {"family": "Kuppermann", "given": "Nathan", "initials": "N"}, {"family": "EKelund", "given": "Ulf", "initials": "U"}], "type": "journal article", "published": "2021-08-21", "journal": {"title": "West J Emerg Med", "issn": "1936-9018", "volume": "22", "issue": "5", "pages": "1037-1044", "issn-l": null}, "abstract": "Emergency departments (ED) globally are addressing the coronavirus disease 2019 (COVID-19) pandemic with varying degrees of success. We leveraged the 17-country, Emergency Medicine Education & Research by Global Experts (EMERGE) network and non-EMERGE ED contacts to understand ED emergency preparedness and practices globally when combating the COVID-19 pandemic.\n\nWe electronically surveyed EMERGE and non-EMERGE EDs from April 3-June 1, 2020 on ED capacity, pandemic preparedness plans, triage methods, staffing, supplies, and communication practices. The survey was available in English, Mandarin Chinese, and Spanish to optimize participation. We analyzed survey responses using descriptive statistics.\n\n74/129 (57%) EDs from 28 countries in all six World Health Organization global regions responded. Most EDs were in Asia (49%), followed by North America (28%), and Europe (14%). Nearly all EDs (97%) developed and implemented protocols for screening, testing, and treating patients with suspected COVID-19 infections. Sixty percent responded that provider staffing/back-up plans were ineffective. Many sites (47/74, 64%) reported staff missing work due to possible illness with the highest provider proportion of COVID-19 exposures and infections among nurses.\n\nDespite having disaster plans in place, ED pandemic preparedness and response continue to be a challenge. Global emergency research networks are vital for generating and disseminating large-scale event data, which is particularly important during a pandemic.", "doi": "10.5811/westjem.2021.3.50358", "pmid": "34546878", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "westjem.2021.3.50358"}, {"db": "pmc", "key": "PMC8463065"}], "notes": [], "created": "2021-10-27T05:11:48.877Z", "modified": "2021-10-27T05:11:48.912Z"}, {"entity": "publication", "iuid": "6a507045616541839ab2f403d1f0b1f5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a507045616541839ab2f403d1f0b1f5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a507045616541839ab2f403d1f0b1f5"}}, "title": "Unexpected details regarding nosocomial transmission revealed by whole-genome sequencing of severe acute respiratory coronavirus virus 2 (SARS-CoV-2).", "authors": [{"family": "Myhrman", "given": "Sofia", "initials": "S", "orcid": "0000-0002-2954-1260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff2d7f2219e24cc39a96bb4e113b8e54.json"}}, {"family": "Olausson", "given": "Josefin", "initials": "J"}, {"family": "Ringlander", "given": "Johan", "initials": "J"}, {"family": "Gustavsson", "given": "Lin\u00e9a", "initials": "L"}, {"family": "Jakobsson", "given": "Hedvig E", "initials": "HE"}, {"family": "Sansone", "given": "Martina", "initials": "M"}, {"family": "Westin", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2021-08-20", "journal": {"title": "Infect Control Hosp Epidemiol", "issn": "1559-6834", "pages": "1-5", "issn-l": "0899-823X"}, "abstract": "Effective infection prevention and control (IPC) measures are key for protecting patients from nosocomial infections and require knowledge of transmission mechanisms in different settings. We performed a detailed outbreak analysis of the transmission and outcome of coronavirus disease 2019 (COVID-19) in a geriatric ward by combining whole-genome sequencing (WGS) with epidemiological data.\n\nRetrospective cohort study.\n\nTertiary-care hospital.\n\nPatients and healthcare workers (HCWs) from the ward with a nasopharyngeal sample (NPS) positive for severe acute respiratory coronavirus virus 2 (SARS-CoV-2) RNA during the outbreak period.\n\nPatient data regarding clinical characteristics, exposure and outcome were collected retrospectively from medical records. Stored NPSs from 32 patients and 15 HCWs were selected for WGS and phylogenetic analysis.\n\nThe median patient age was 84 years and 17 (53%) of 32 were male. Also, 14 patients (44%) died within 30 days of sampling. Viral loads were significantly higher among the deceased. WGS was successful in 28 (88%) of 32 patient samples and 14 (93%) of 15 HCW samples. Moreover, 3 separate viral clades were identified: 1 clade and 2 subclades among both patient and HCW samples. Integrated epidemiological and genetic analyses revealed 6 probable transmission events between patients and supported hospital-acquired COVID-19 among 25 of 32 patients.\n\nWGS provided an insight into the outbreak dynamics and true extent of nosocomial COVID-19. The extensive transmission between patients and HCWs indicated that current IPC measures were insufficient. We recommend increased use of WGS in outbreak investigations to identify otherwise unknown transmission links and to evaluate IPC measures.", "doi": "10.1017/ice.2021.374", "pmid": "34496989", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0899823X21003743"}], "notes": [], "created": "2021-09-13T06:06:19.296Z", "modified": "2021-09-13T06:06:19.338Z"}, {"entity": "publication", "iuid": "5c63ba50a60041fd80e0adc526bb1f27", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c63ba50a60041fd80e0adc526bb1f27.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c63ba50a60041fd80e0adc526bb1f27"}}, "title": "Axillary lymphadenopathy at the time of COVID-19 vaccination: ten recommendations from the European Society of Breast Imaging (EUSOBI).", "authors": [{"family": "Schiaffino", "given": "Simone", "initials": "S"}, {"family": "Pinker", "given": "Katja", "initials": "K"}, {"family": "Magni", "given": "Veronica", "initials": "V"}, {"family": "Cozzi", "given": "Andrea", "initials": "A"}, {"family": "Athanasiou", "given": "Alexandra", "initials": "A"}, {"family": "Baltzer", "given": "Pascal A T", "initials": "PAT"}, {"family": "Camps Herrero", "given": "Julia", "initials": "J"}, {"family": "Clauser", "given": "Paola", "initials": "P"}, {"family": "Fallenberg", "given": "Eva M", "initials": "EM"}, {"family": "Forrai", "given": "G\u00e1bor", "initials": "G"}, {"family": "Fuchsj\u00e4ger", "given": "Michael H", "initials": "MH"}, {"family": "Helbich", "given": "Thomas H", "initials": "TH"}, {"family": "Kilburn-Toppin", "given": "Fleur", "initials": "F"}, {"family": "Kuhl", "given": "Christiane K", "initials": "CK"}, {"family": "Lesaru", "given": "Mihai", "initials": "M"}, {"family": "Mann", "given": "Ritse M", "initials": "RM"}, {"family": "Panizza", "given": "Pietro", "initials": "P"}, {"family": "Pediconi", "given": "Federica", "initials": "F"}, {"family": "Pijnappel", "given": "Ruud M", "initials": "RM"}, {"family": "Sella", "given": "Tamar", "initials": "T"}, {"family": "Thomassin-Naggara", "given": "Isabelle", "initials": "I"}, {"family": "Zackrisson", "given": "Sophia", "initials": "S"}, {"family": "Gilbert", "given": "Fiona J", "initials": "FJ"}, {"family": "Sardanelli", "given": "Francesco", "initials": "F", "orcid": "0000-0001-6545-9427", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6ef97ff0f9b4b9b8b0c4396276bebe3.json"}}], "type": "journal article", "published": "2021-08-20", "journal": {"title": "Insights Imaging", "issn": "1869-4101", "volume": "12", "issue": "1", "pages": "119", "issn-l": null}, "abstract": "Unilateral axillary lymphadenopathy is a frequent mild side effect of COVID-19 vaccination. European Society of Breast Imaging (EUSOBI) proposes ten recommendations to standardise its management and reduce unnecessary additional imaging and invasive procedures: (1) in patients with previous history of breast cancer, vaccination should be performed in the contralateral arm or in the thigh; (2) collect vaccination data for all patients referred to breast imaging services, including patients undergoing breast cancer staging and follow-up imaging examinations; (3) perform breast imaging examinations preferentially before vaccination or at least 12 weeks after the last vaccine dose; (4) in patients with newly diagnosed breast cancer, apply standard imaging protocols regardless of vaccination status; (5) in any case of symptomatic or imaging-detected axillary lymphadenopathy before vaccination or at least 12 weeks after, examine with appropriate imaging the contralateral axilla and both breasts to exclude malignancy; (6) in case of axillary lymphadenopathy contralateral to the vaccination side, perform standard work-up; (7) in patients without breast cancer history and no suspicious breast imaging findings, lymphadenopathy only ipsilateral to the vaccination side within 12 weeks after vaccination can be considered benign or probably-benign, depending on clinical context; (8) in patients without breast cancer history, post-vaccination lymphadenopathy coupled with suspicious breast finding requires standard work-up, including biopsy when appropriate; (9) in patients with breast cancer history, interpret and manage post-vaccination lymphadenopathy considering the timeframe from vaccination and overall nodal metastatic risk; (10) complex or unclear cases should be managed by the multidisciplinary team.", "doi": "10.1186/s13244-021-01062-x", "pmid": "34417642", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13244-021-01062-x"}, {"db": "pmc", "key": "PMC8378785"}], "notes": [], "created": 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"https://publications-covid19.scilifelab.se/researcher/22f57b7602714f59bfbcc96a936d77a8.json"}}, {"family": "Bonfanti", "given": "Paolo", "initials": "P", "orcid": "0000-0001-7289-8823", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52b16f4f4f5c4031a8435f6f17e791c7.json"}}, {"family": "Biondi", "given": "Andrea", "initials": "A"}, {"family": "Tubiana", "given": "Sarah", "initials": "S", "orcid": "0000-0002-6526-6403", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c1b73b9bbe34e7b8f2b4acb82f9f438.json"}}, {"family": "Burdet", "given": "Charles", "initials": "C"}, {"family": "Nussbaum", "given": "Robert", "initials": "R", "orcid": "0000-0003-3445-8880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aabd2609b3e040328310c013efa546b2.json"}}, {"family": "Kahn-Kirby", "given": "Amanda", "initials": "A", "orcid": "0000-0002-8878-0413", "researcher": {"href": 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"researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ee6f7f1803e47de83ccf6f89964bce0.json"}}, {"family": "Puel", "given": "Anne", "initials": "A", "orcid": "0000-0003-2603-0323", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2bdac14a1d14b8496ffd12dac6df3e5.json"}}, {"family": "Boisson-Dupuis", "given": "St\u00e9phanie", "initials": "S", "orcid": "0000-0002-7115-116X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92c785f151bb490aa85764eb62c0508e.json"}}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "B\u00e9ziat", "given": "Vivien", "initials": "V", "orcid": "0000-0002-4020-824X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ec4013e8c1f41d3b3590231e846cfc6.json"}}, {"family": "Lifton", "given": "Richard P", "initials": "RP"}, {"family": "Bastard", "given": "Paul", "initials": "P", "orcid": "0000-0002-5926-8437", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e3388c840d04a25824530a9bf999f01.json"}}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD", "orcid": "0000-0002-8335-0262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3f0c0bf3c294622a95b062a5db4386d.json"}}, {"family": "Abel", "given": "Laurent", "initials": "L", "orcid": "0000-0001-7016-6493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fd6c4593c8c492a8dad8e49cb7a832a.json"}}, {"family": "Su", "given": "Helen C", "initials": "HC", "orcid": "0000-0002-5582-9110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad550813f03540d9a8240a3d96ad0829.json"}}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E", "orcid": "0000-0002-7358-9157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c50d261245743539a5813daffcaab72.json"}}, {"family": "Amara", "given": "Ali", "initials": "A"}, {"family": "Soumelis", "given": "Vassili", "initials": "V", "orcid": "0000-0003-1849-9834", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f213b2e1c984894b695760448e0f35b.json"}}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5369fe152ac94b5a81d4f913d85940a7.json"}}, {"family": "Zhang", "given": "Qian", "initials": "Q", "orcid": "0000-0002-9040-3289", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/341c0cb0fa7d41448e55344c82d68358.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL", "orcid": "0000-0002-7782-4169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1aca66ab7c39465faf2de03fa8a6722f.json"}}], "type": "journal article", "published": "2021-08-19", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "volume": "6", "issue": "62", "pages": "eabl4348", "issn-l": "2470-9468"}, "abstract": "Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare, biochemically deleterious X-linked TLR7 variants in 16 unrelated male individuals aged 7 to 71 years (mean: 36.7 years) from a cohort of 1,202 male patients aged 0.5 to 99 years (mean: 52.9 years) with unexplained critical COVID-19 pneumonia. None of the 331 asymptomatically or mildly infected male individuals aged 1.3 to 102 years (mean: 38.7 years) tested carry such TLR7 variants (p = 3.5 \u00d7 10-5). The phenotypes of five hemizygous relatives of index cases infected with SARS-CoV-2 include asymptomatic or mild infection (n=2, 5 and 38 years), or moderate (n=1, 5 years), severe (n=1, 27 years), or critical (n=1, 29 years) pneumonia. Two boys (aged 7 and 12 years) from a cohort of 262 male patients with severe COVID-19 pneumonia (mean: 51.0 years) are hemizygous for a deleterious TLR7 variant. The cumulative allele frequency for deleterious TLR7 variants in the male general population is < 6.5x10-4 We also show that blood B cell lines and myeloid cell subsets from the patients do not respond to TLR7 stimulation, a phenotype rescued by wild-type TLR7 The patients' blood plasmacytoid dendritic cells (pDCs) produce low levels of type I IFNs in response to SARS-CoV-2. Overall, X-linked recessive TLR7 deficiency is a highly penetrant genetic etiology of critical COVID-19 pneumonia, in about 1.8% of male patients below the age of 60 years. Human TLR7 and pDCs are essential for protective type I IFN immunity against SARS-CoV-2 in the respiratory tract.", "doi": "10.1126/sciimmunol.abl4348", "pmid": "34413140", "labels": {"Category: Proteins": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "mid", "key": "NIHMS1744435"}, {"db": "pmc", "key": "PMC8532080"}, {"db": "pii", "key": "6/62/eabl4348"}], "notes": [], "created": "2021-08-20T12:26:45.378Z", "modified": "2023-06-19T15:35:54.456Z"}, {"entity": "publication", "iuid": "7e0426156b054faf9b603d4ccb53cf7f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e0426156b054faf9b603d4ccb53cf7f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e0426156b054faf9b603d4ccb53cf7f"}}, "title": "Children's Expressions of Worry During the COVID-19 Pandemic in Sweden.", "authors": [{"family": "Sarkadi", "given": "Anna", "initials": "A"}, {"family": "Sahlin Torp", "given": "Lisa", "initials": "L"}, {"family": "P\u00e9rez-Aronsson", "given": "Anna", "initials": "A"}, {"family": "Warner", "given": "Georgina", "initials": "G", "orcid": "0000-0002-7850-9136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a44058151a6c4ff4be148921ad1e9e57.json"}}], "type": "journal article", "published": "2021-08-19", "journal": {"title": "J Pediatr Psychol", "issn": "1465-735X", "volume": "46", "issue": "8", "pages": "939-949", "issn-l": null}, "abstract": "Sweden is an international exception in its public health response to the COVID-19 pandemic, with a higher number of deaths, albeit not pediatric, compared with other Nordic countries. The objective of this study was to investigate what worries children and adolescents living in Sweden expressed in relation to the pandemic.\n\nUsing an anonymous web-survey, 1,047 children (4-12 years; N = 717) and adolescents (13-18 years; N = 330) responded to five background and four open-ended questions, one of which was: Is there anything that you are worried about when it comes to 'Corona'? The responses were coded using manifest content analysis. Interrater reliability was .95, assessed on the code level.\n\nWorry was common (77%); mostly (60%) related to disease or death of elderly relatives, parents, the child him/herself or general worry for the elderly/risk groups. Existential worry (15%) comprised worries about the future, including economy and worries about the world perishing or the contagion becoming uncontrollable. A developmental trajectory was evident in the nature of responses. Adolescents' worries about the future included missing out on their youth and employment. They also worried about society (6%), for example, the future of democracy and the world economy. There was no indication of socioeconomic status or geographic area (urban vs. rural) affecting the presence of worrisome thoughts.\n\nWorry about \"Corona\" was common. Universal preventative mental health intervention is warranted and could be conducted in the school setting. Intervention could be tailored by age, covering discussion on financial aspects with adolescents.", "doi": "10.1093/jpepsy/jsab060", "pmid": "34383921", "labels": {"Category: Public Health": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8376257"}, {"db": "pii", "key": "6349212"}], "notes": [], "created": "2023-01-13T13:42:08.183Z", "modified": "2023-01-13T13:42:08.229Z"}, {"entity": "publication", "iuid": "4a0182dcbd774f28879aa1e57743de3a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4a0182dcbd774f28879aa1e57743de3a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4a0182dcbd774f28879aa1e57743de3a"}}, "title": "Changes in Adolescents' Psychosocial Functioning and Well-Being as a Consequence of Long-Term COVID-19 Restrictions.", "authors": [{"family": "Kerekes", "given": "N\u00f3ra", "initials": "N", "orcid": "0000-0002-8854-0399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/175ef55a6f3b45909a0a76b55cc0e4b3.json"}}, {"family": "Bador", "given": "Kourosh", "initials": "K"}, {"family": "Sfendla", "given": "Anis", "initials": "A", "orcid": "0000-0001-7139-7058", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6f24957ee1054495b1e970210d5e1fb1.json"}}, {"family": "Belaatar", "given": "Mohjat", "initials": "M"}, {"family": "Mzadi", "given": "Abdennour El", "initials": "AE", "orcid": "0000-0002-0309-3586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d613682c3d36435c9bf4d0ec63d1c3fd.json"}}, {"family": "Jovic", "given": "Vladimir", "initials": "V"}, {"family": "Damjanovic", "given": "Rade", "initials": "R"}, {"family": "Erlandsson", "given": "Maria", "initials": "M"}, {"family": "Nguyen", "given": "Hang Thi Minh", "initials": "HTM"}, {"family": "Nguyen", "given": "Nguyet Thi Anh", "initials": "NTA"}, {"family": "Ulberg", "given": "Scott F", "initials": "SF"}, {"family": "Kuch-Cecconi", "given": "Rachael H", "initials": "RH"}, {"family": "Szombathyne Meszaros", "given": "Zsuzsa", "initials": "Z"}, {"family": "Stevanovic", "given": "Dejan", "initials": "D", "orcid": "0000-0001-8236-5246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fd2d9e3b1114cf5bd2a89e5ab0dc766.json"}}, {"family": "Senhaji", "given": "Meftaha", "initials": "M"}, {"family": "Hedman Ahlstr\u00f6m", "given": "Britt", "initials": "B"}, {"family": "Zouini", "given": "Btissame", "initials": "B", "orcid": "0000-0002-9692-2397", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8935bc90d78143139467d7cfe522f70a.json"}}], "type": "journal article", "published": "2021-08-19", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "16", "pages": null}, "abstract": "This work studied self-reports from adolescents on how the COVID-19 pandemic has changed their behaviors, relationships, mood, and victimization. Data collection was conducted between September 2020 and February 2021 in five countries (Sweden, the USA, Serbia, Morocco, and Vietnam). In total, 5114 high school students (aged 15 to 19 years, 61.8% females) responded to our electronic survey. A substantial proportion of students reported decreased time being outside (41.7%), meeting friends in real life (59.4%), and school performance (30.7%), while reporting increased time to do things they did not have time for before (49.3%) and using social media to stay connected (44.9%). One third of the adolescents increased exercise and felt that they have more control over their life. Only a small proportion of adolescents reported substance use, norm-breaking behaviors, or victimization. The overall COVID-19 impact on adolescent life was gender-specific: we found a stronger negative impact on female students. The results indicated that the majority of adolescents could adapt to the dramatic changes in their environment. However, healthcare institutions, municipalities, schools, and social services could benefit from the findings of this study in their work to meet the needs of those young people who signaled worsened psychosocial functioning, increased stress, and victimization.", "doi": "10.3390/ijerph18168755", "pmid": "34444502", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph18168755"}, {"db": "pmc", "key": "PMC8392883"}], "notes": [], "created": "2021-09-01T07:27:23.293Z", "modified": "2021-11-18T13:38:07.614Z"}, {"entity": "publication", "iuid": "1f6e2f184718454591ec16406ead3ed1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1f6e2f184718454591ec16406ead3ed1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1f6e2f184718454591ec16406ead3ed1"}}, "title": "Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.", "authors": [{"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Gervais", "given": "Adrian", "initials": "A"}, {"family": "Le Voyer", "given": "Tom", "initials": "T"}, {"family": "Rosain", "given": "J\u00e9r\u00e9mie", "initials": "J"}, {"family": "Philippot", "given": "Quentin", "initials": "Q"}, {"family": "Manry", "given": "J\u00e9r\u00e9my", "initials": "J"}, {"family": "Michailidis", "given": "Eleftherios", "initials": "E"}, {"family": "Hoffmann", "given": "Hans-Heinrich", "initials": "HH"}, {"family": "Eto", "given": "Shohei", "initials": "S"}, {"family": "Garcia-Prat", "given": "Marina", "initials": "M"}, {"family": "Bizien", "given": "Lucy", "initials": "L"}, {"family": "Parra-Mart\u00ednez", "given": "Alba", "initials": "A"}, {"family": "Yang", "given": "Rui", "initials": "R"}, {"family": "Haljasm\u00e4gi", "given": "Liis", "initials": "L"}, {"family": "Migaud", "given": "M\u00e9lanie", "initials": "M"}, {"family": "S\u00e4rekannu", "given": "Karita", "initials": "K"}, {"family": "Maslovskaja", "given": "Julia", "initials": "J"}, {"family": "de Prost", "given": "Nicolas", "initials": "N"}, {"family": "Tandjaoui-Lambiotte", "given": "Yacine", "initials": "Y"}, {"family": "Luyt", "given": "Charles-Edouard", "initials": "CE"}, {"family": "Amador-Borrero", "given": "Blanca", "initials": "B"}, {"family": "Gaudet", "given": "Alexandre", "initials": "A"}, {"family": "Poissy", "given": "Julien", "initials": "J"}, {"family": "Morel", "given": "Pascal", "initials": "P"}, {"family": "Richard", "given": "Pascale", "initials": "P"}, {"family": "Cognasse", "given": "Fabrice", "initials": "F"}, {"family": "Troya", "given": "Jesus", "initials": "J"}, {"family": "Trouillet-Assant", "given": "Sophie", "initials": "S"}, {"family": "Belot", "given": "Alexandre", "initials": "A"}, {"family": "Saker", "given": "Kahina", "initials": "K"}, {"family": "Gar\u00e7on", "given": "Pierre", "initials": "P"}, {"family": "Rivi\u00e8re", "given": "Jacques G", "initials": "JG"}, {"family": "Lagier", "given": "Jean-Christophe", "initials": "JC"}, {"family": "Gentile", "given": "St\u00e9phanie", "initials": "S"}, {"family": "Rosen", "given": "Lindsey B", "initials": "LB"}, {"family": "Shaw", "given": "Elana", "initials": "E"}, {"family": "Morio", "given": "Tomohiro", "initials": "T"}, {"family": "Tanaka", "given": "Junko", "initials": "J"}, {"family": "Dalmau", "given": "David", "initials": "D"}, {"family": "Tharaux", "given": "Pierre-Louis", "initials": "PL"}, {"family": "Sene", "given": "Damien", "initials": "D"}, {"family": "Stepanian", "given": "Alain", "initials": "A"}, {"family": "Megarbane", "given": "Bruno", "initials": "B"}, {"family": "Triantafyllia", "given": "Vasiliki", "initials": "V"}, {"family": "Fekkar", "given": "Arnaud", "initials": "A"}, {"family": "Heath", "given": "James R", "initials": "JR"}, {"family": "Franco", "given": "Jos\u00e9 Luis", "initials": "JL"}, {"family": "Anaya", 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{"family": "Arrestier", "given": "Romain", "initials": "R"}, {"family": "Boudhabhay", "given": "Idris", "initials": "I"}, {"family": "Baris-Feldman", "given": "Hagit", "initials": "H"}, {"family": "Hagin", "given": "David", "initials": "D"}, {"family": "Wauters", "given": "Joost", "initials": "J"}, {"family": "Meyts", "given": "Isabelle", "initials": "I"}, {"family": "Dyer", "given": "Adam H", "initials": "AH"}, {"family": "Kennelly", "given": "Sean P", "initials": "SP"}, {"family": "Bourke", "given": "Nollaig M", "initials": "NM"}, {"family": "Halwani", "given": "Rabih", "initials": "R"}, {"family": "Sharif-Askari", "given": "Narjes Saheb", "initials": "NS"}, {"family": "Dorgham", "given": "Karim", "initials": "K"}, {"family": "Sallette", "given": "J\u00e9rome", "initials": "J"}, {"family": "Sedkaoui", "given": "Souad Mehlal", "initials": "SM"}, {"family": "AlKhater", "given": "Suzan", "initials": "S"}, {"family": "Rigo-Bonnin", "given": "Ra\u00fal", "initials": "R"}, {"family": "Morandeira", "given": "Francisco", "initials": "F"}, {"family": "Roussel", "given": "Lucie", "initials": "L"}, {"family": "Vinh", "given": "Donald C", "initials": "DC"}, {"family": "Ostrowski", "given": "Sisse Rye", "initials": "SR"}, {"family": "Condino-Neto", "given": "Antonio", "initials": "A"}, {"family": "Prando", "given": "Carolina", "initials": "C"}, {"family": "Bonradenko", "given": "Anastasiia", "initials": "A"}, {"family": "Spaan", "given": "Andr\u00e1s N", "initials": "AN"}, {"family": "Gilardin", "given": "Laurent", "initials": "L"}, {"family": "Fellay", "given": "Jacques", "initials": "J"}, {"family": "Lyonnet", "given": "Stanislas", "initials": "S"}, {"family": "Bilguvar", "given": "Kaya", "initials": "K"}, {"family": "Lifton", "given": "Richard P", "initials": "RP"}, {"family": "Mane", "given": "Shrikant", "initials": "S"}, {"family": "HGID Lab", "given": "", "initials": ""}, {"family": "COVID Clinicians", "given": "", "initials": ""}, {"family": "COVID-STORM 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{"family": "3C-Dijon Study", "given": "", "initials": ""}, {"family": "Cerba Health-Care", "given": "", "initials": ""}, {"family": "Etablissement du Sang study group", "given": "", "initials": ""}, {"family": "Anderson", "given": "Mark S", "initials": "MS"}, {"family": "Boisson", "given": "Bertrand", "initials": "B"}, {"family": "B\u00e9ziat", "given": "Vivien", "initials": "V"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Vandreakos", "given": "Evangelos", "initials": "E"}, {"family": "Hermine", "given": "Olivier", "initials": "O"}, {"family": "Pujol", "given": "Aurora", "initials": "A"}, {"family": "Peterson", "given": "P\u00e4rt", "initials": "P"}, {"family": "Mogensen", "given": "Trine H", "initials": "TH"}, {"family": "Rowen", "given": "Lee", "initials": "L"}, {"family": "Mond", "given": "James", "initials": "J"}, {"family": "Debette", "given": "St\u00e9phanie", "initials": "S"}, {"family": "de Lamballerie", "given": "Xavier", "initials": "X"}, {"family": "Duval", "given": "Xavier", "initials": "X"}, {"family": "Mentr\u00e9", "given": "France", "initials": "F"}, {"family": "Zins", "given": "Marie", "initials": "M"}, {"family": "Soler-Palacin", "given": "Pere", "initials": "P"}, {"family": "Colobran", "given": "Roger", "initials": "R"}, {"family": "Gorochov", "given": "Guy", "initials": "G"}, {"family": "Solanich", "given": "Xavier", "initials": "X"}, {"family": "Susen", "given": "Sophie", "initials": "S"}, {"family": "Martinez-Picado", "given": "Javier", "initials": "J"}, {"family": "Raoult", "given": "Didier", "initials": "D"}, {"family": "Vasse", "given": "Marc", "initials": "M"}, {"family": "Gregersen", "given": "Peter K", "initials": "PK"}, {"family": "Piemonti", "given": "Lorenzo", "initials": "L"}, {"family": "Rodr\u00edguez-Gallego", "given": "Carlos", "initials": "C"}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD"}, {"family": "Su", "given": "Helen C", "initials": "HC"}, {"family": "Kisand", "given": "Kai", "initials": "K"}, {"family": "Okada", "given": "Satoshi", "initials": "S"}, {"family": "Puel", "given": "Anne", "initials": "A"}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E"}, {"family": "Rice", "given": "Charles M", "initials": "CM"}, {"family": "Tiberghien", "given": "Pierre", "initials": "P"}, {"family": "Zhang", "given": "Qian", "initials": "Q"}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A"}, {"family": "Abel", "given": "Laurent", "initials": "L"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL"}], "type": "journal article", "published": "2021-08-19", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "issn-l": "2470-9468", "volume": "6", "issue": "62", "pages": "eabl4340"}, "abstract": "Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-\u03b1 and/or -\u03c9 are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-\u03b1 and/or -\u03c9 (100 pg/mL, in 1/10 dilutions of plasma) in 13.6% of 3,595 patients with critical COVID-19, including 21% of 374 patients > 80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1,124 deceased patients (aged 20 days-99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-\u03b2. We also show, in a sample of 34,159 uninfected subjects from the general population, that auto-Abs neutralizing high concentrations of IFN-\u03b1 and/or -\u03c9 are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of subjects carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-\u03b2 do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over-80s, and total fatal COVID-19 cases.", "doi": "10.1126/sciimmunol.abl4340", "pmid": "34413139", "labels": {"Category: Proteins": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "mid", "key": "NIHMS1744468"}, {"db": "pmc", "key": "PMC8521484"}, {"db": "pii", "key": "6/62/eabl4340"}], "notes": [], "created": "2021-08-20T06:48:41.370Z", "modified": "2023-06-19T15:35:29.233Z"}, {"entity": "publication", "iuid": "7a67796ea81f41569b69fcc5d74102d3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a67796ea81f41569b69fcc5d74102d3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a67796ea81f41569b69fcc5d74102d3"}}, "title": "Two cases of severe COVID-19 in gestational week 27 and 28 respectively, after which both pregnancies proceeded to term.", "authors": [{"family": "\u00d6stling", "given": "H", "initials": "H"}, {"family": "Ugarph-Edfeldt", "given": "M", "initials": "M"}, {"family": "Hild\u00e9n", "given": "K", "initials": "K"}], "type": "case reports", "published": "2021-08-18", "journal": {"title": "Int J Obstet Anesth", "issn": "1532-3374", "volume": "48", "pages": "103212", "issn-l": null}, "abstract": "COVID-19 in pregnancy increases the risk of caesarean section. We present two cases of late gestation pregnant women with severe COVID-19. Both were successfully treated with mechanical ventilation without termination of pregnancy and, following recovery from COVID-19, had vaginal deliveries at term. These two cases demonstrate the possibility of treating pregnant women with severe COVID-19 with mechanical ventilation in the late second and early third trimesters without them having a pre-term delivery. With a multidisciplinary approach, such management could avoid the maternal risks of surgery during a severe infection and, at the same time, enable term birth with a lower risk of neonatal complications.", "doi": "10.1016/j.ijoa.2021.103212", "pmid": "34500190", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0959-289X(21)00270-3"}, {"db": "pmc", "key": "PMC8372455"}], "notes": [], "created": "2021-09-13T06:07:55.917Z", "modified": "2021-09-13T06:07:55.944Z"}, {"entity": "publication", "iuid": "30a815cc31754725934d9486c0e487ac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/30a815cc31754725934d9486c0e487ac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/30a815cc31754725934d9486c0e487ac"}}, "title": "Fear of COVID-19 and religious coping mediate the associations between religiosity and distress among older adults.", "authors": [{"family": "Asgari Ghoncheh", "given": "Karim", "initials": "K", "orcid": "0000-0003-0127-9480", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac0b0c26ed9246f4b4f4f75c80fce4da.json"}}, {"family": "Liu", "given": "Chieh-Hsiu", "initials": "CH"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Saffari", "given": "Mohsen", "initials": "M"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-08-18", "journal": {"title": "Health Promot Perspect", "issn": "2228-6497", "volume": "11", "issue": "3", "pages": "316-322", "issn-l": null}, "abstract": "Background: A mediation model was proposed to explain how religiosity, religious coping, and fear of coronavirus disease 2019 (COVID-19) explained anxiety and depression among older adults. Methods: With the use of a cross-sectional design, the Integrated Health System was used to randomly invite 1000 older adults residing in Qazvin to participate in an online survey. Within the period of November 2020 to January 2021, 696 older Iranian adults (mean age=69.56years; 57.9% women) agreed to participate in the study and reported demographic information as well as measures of religiosity, fear of COVID-19, religious coping, anxiety, and depression. Results: Religiosity had direct effects on depression (B [SE]=-0.087 [0.037]; P=0.023) but not anxiety (B [SE]=-0.063 [0.036]; P=0.072). Moreover, both fear of COVID-19 and religious coping significantly mediated the association between religiosity and anxiety (B [SE]=-0.360[0.035]; p=0.002) and that between religiosity and depression (B [SE]=-0.365 [0.034];P=0.002). Conclusion: During the tough time of COVID-19 pandemic, religiosity and religious coping were protectors for older adults in developing good mental. Therefore, future research is needed to examine education programs that are effective for older adults to obtain correct knowledge concerning COVID-19, including the protective COVID-19 infection behaviors. Therefore, older adults may reduce their fear via their enhanced correct knowledge concerning COVID-19.", "doi": "10.34172/hpp.2021.40", "pmid": "34660226", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8501474"}], "notes": [], "created": "2021-10-21T05:00:52.748Z", "modified": "2021-10-21T05:00:52.832Z"}, {"entity": "publication", "iuid": "7d7f3577978a4f85a174146b372fc4a5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d7f3577978a4f85a174146b372fc4a5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d7f3577978a4f85a174146b372fc4a5"}}, "title": "Southeast Asia is an emerging hotspot for COVID-19.", "authors": [{"family": "Chookajorn", "given": "Thanat", "initials": "T", "orcid": "0000-0003-2876-6203", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d23832ce2a8a4f1aaa4420c4beb68da3.json"}}, {"family": "Kochakarn", "given": "Theerarat", "initials": "T", "orcid": "0000-0002-3524-8079", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89f005dd677d4a118a343d260dd8a3ef.json"}}, {"family": "Wilasang", "given": "Chaiwat", "initials": "C"}, {"family": "Kotanan", "given": "Namfon", "initials": "N"}, {"family": "Modchang", "given": "Charin", "initials": "C"}], "type": "letter", "published": "2021-08-16", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956"}, "abstract": null, "doi": "10.1038/s41591-021-01471-x", "pmid": "34400842", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-021-01471-x"}], "notes": [], "created": "2021-08-18T07:32:32.235Z", "modified": "2021-08-18T07:32:32.304Z"}, {"entity": "publication", "iuid": "1148627e160a4b4c83b7700fd26ae64d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1148627e160a4b4c83b7700fd26ae64d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1148627e160a4b4c83b7700fd26ae64d"}}, "title": "No difference in biomarkers of ischemic heart injury and heart failure in patients with COVID-19 who received treatment with chloroquine phosphate and those who did not.", "authors": [{"family": "Beck-Friis", "given": "Josefine", "initials": "J", "orcid": "0000-0003-2400-4092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3f3764c8d95410abc83f9c3cca2eaeb.json"}}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Omerovic", "given": "Elmir", "initials": "E"}, {"family": "Zeijlon", "given": "Rickard", "initials": "R", "orcid": "0000-0001-6422-604X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ad7b579fe034ce0b8baf9c7b9209c4f.json"}}, {"family": "Gisslen", "given": "Magnus", "initials": "M"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}], "type": "journal article", "published": "2021-08-16", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "8", "pages": "e0256035"}, "abstract": "Chloroquine was promoted as a COVID-19 therapeutic early in the pandemic. Most countries have since discontinued the use of chloroquine due to lack of evidence of any benefit and the risk of severe adverse events. The primary aim of this study was to examine if administering chloroquine during COVID-19 imposed an increased risk of ischemic heart injury or heart failure.\n\nMedical records, laboratory findings, and electrocardiograms of patients with COVID-19 who were treated with 500 mg chloroquine phosphate daily and controls not treated with chloroquine were reviewed retrospectively. Controls were matched in age and severity of disease.\n\nWe included 20 patients receiving chloroquine (500 mg twice daily) for an average of five days, and 40 controls. The groups were comparable regarding demographics and biochemical analyses including C-reactive protein, thrombocytes, and creatinine. There were no statistically significant differences in cardiac biomarkers or in electrocardiograms. Median troponin T was 10,8 ng/L in the study group and 17.9 ng/L in the control group, whereas median NT-proBNP was 399 ng/L in patients receiving chloroquine and 349 ng/L in the controls.\n\nWe found no increased risk of ischemic heart injury or heart failure as a result of administering chloroquine. However, the use of chloroquine to treat COVID-19 outside of clinical trials is not recommended, considering the lack of evidence of its effectiveness, as well as the elevated risk of fatal arrythmias.", "doi": "10.1371/journal.pone.0256035", "pmid": "34398893", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8366976"}, {"db": "pii", "key": "PONE-D-21-05531"}], "notes": [], "created": "2021-08-17T06:33:30.817Z", "modified": "2023-06-19T14:22:31.683Z"}, {"entity": "publication", "iuid": "f4d2a4bb9cc542238ce4a63f1852e405", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f4d2a4bb9cc542238ce4a63f1852e405.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f4d2a4bb9cc542238ce4a63f1852e405"}}, "title": "The New Generation hDHODH Inhibitor MEDS433 Hinders the In Vitro Replication of SARS-CoV-2 and Other Human Coronaviruses.", "authors": [{"family": "Calistri", "given": "Arianna", "initials": "A", "orcid": "0000-0002-6881-7936", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbe9daeedf2e470da0d6dc15c0ad0b42.json"}}, {"family": "Luganini", "given": "Anna", "initials": "A", "orcid": "0000-0003-4256-5774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d50b50e8ca94f6cae15ba017327c531.json"}}, {"family": "Mognetti", "given": "Barbara", "initials": "B", "orcid": "0000-0003-2888-8999", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d3c5265b63e4d5b876a49be6ff1fdcb.json"}}, {"family": "Elder", "given": "Elizabeth", "initials": "E"}, {"family": "Sibille", "given": "Giulia", "initials": "G", "orcid": "0000-0002-2869-357X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c182e329cc844e8a77cc79d9aa3066b.json"}}, {"family": "Conciatori", "given": "Valeria", "initials": "V"}, {"family": "Del Vecchio", "given": "Claudia", "initials": "C"}, {"family": "Sainas", "given": "Stefano", "initials": "S", "orcid": "0000-0001-5010-8536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76b9175a3f6948ce805df8750a31af27.json"}}, {"family": "Boschi", "given": "Donatella", "initials": "D", "orcid": "0000-0003-4929-4460", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/553f31793fda4fffb7b98c6ffe323957.json"}}, {"family": "Montserrat", "given": "Nuria", "initials": "N"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Lolli", "given": "Marco Lucio", "initials": "ML"}, {"family": "Gribaudo", "given": "Giorgio", "initials": "G", "orcid": "0000-0002-1583-9146", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b1ea434d6b04d26a764cde7dd4ff21b.json"}}, {"family": "Parolin", "given": "Cristina", "initials": "C"}], "type": "journal article", "published": "2021-08-14", "journal": {"title": "Microorganisms", "issn": "2076-2607", "issn-l": "2076-2607", "volume": "9", "issue": "8", "pages": "1731"}, "abstract": "Although coronaviruses (CoVs) have long been predicted to cause zoonotic diseases and pandemics with high probability, the lack of effective anti-pan-CoVs drugs rapidly usable against the emerging SARS-CoV-2 actually prevented a promptly therapeutic intervention for COVID-19. Development of host-targeting antivirals could be an alternative strategy for the control of emerging CoVs infections, as they could be quickly repositioned from one pandemic event to another. To contribute to these pandemic preparedness efforts, here we report on the broad-spectrum CoVs antiviral activity of MEDS433, a new inhibitor of the human dihydroorotate dehydrogenase (hDHODH), a key cellular enzyme of the de novo pyrimidine biosynthesis pathway. MEDS433 inhibited the in vitro replication of hCoV-OC43 and hCoV-229E, as well as of SARS-CoV-2, at low nanomolar range. Notably, the anti-SARS-CoV-2 activity of MEDS433 against SARS-CoV-2 was also observed in kidney organoids generated from human embryonic stem cells. Then, the antiviral activity of MEDS433 was reversed by the addition of exogenous uridine or the product of hDHODH, the orotate, thus confirming hDHODH as the specific target of MEDS433 in hCoVs-infected cells. Taken together, these findings suggest MEDS433 as a potential candidate to develop novel drugs for COVID-19, as well as broad-spectrum antiviral agents exploitable for future CoVs threats.", "doi": "10.3390/microorganisms9081731", "pmid": "34442810", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8398173"}, {"db": "pii", "key": "microorganisms9081731"}], "notes": [], "created": "2021-09-01T07:26:00.780Z", "modified": "2023-06-19T14:33:43.533Z"}, {"entity": "publication", "iuid": "1b3ba7feed27435d99d45ec43fa13eb4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b3ba7feed27435d99d45ec43fa13eb4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b3ba7feed27435d99d45ec43fa13eb4"}}, "title": "Risk of acute myocardial infarction and ischaemic stroke following COVID-19 in Sweden: a self-controlled case series and matched cohort study.", "authors": [{"family": "Katsoularis", "given": "Ioannis", "initials": "I"}, {"family": "Fonseca-Rodr\u00edguez", "given": "Osvaldo", "initials": "O"}, {"family": "Farrington", "given": "Paddy", "initials": "P"}, {"family": "Lindmark", "given": "Krister", "initials": "K"}, {"family": "Fors Connolly", "given": "Anne-Marie", "initials": "AM"}], "type": "journal article", "published": "2021-08-14", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "398", "issue": "10300", "pages": "599-607", "issn-l": "0140-6736"}, "abstract": "COVID-19 is a complex disease targeting many organs. Previous studies highlight COVID-19 as a probable risk factor for acute cardiovascular complications. We aimed to quantify the risk of acute myocardial infarction and ischaemic stroke associated with COVID-19 by analysing all COVID-19 cases in Sweden.\n\nThis self-controlled case series (SCCS) and matched cohort study was done in Sweden. The personal identification numbers of all patients with COVID-19 in Sweden from Feb 1 to Sept 14, 2020, were identified and cross-linked with national inpatient, outpatient, cancer, and cause of death registers. The controls were matched on age, sex, and county of residence in Sweden. International Classification of Diseases codes for acute myocardial infarction or ischaemic stroke were identified in causes of hospital admission for all patients with COVID-19 in the SCCS and all patients with COVID-19 and the matched control individuals in the matched cohort study. The SCCS method was used to calculate the incidence rate ratio (IRR) for first acute myocardial infarction or ischaemic stroke following COVID-19 compared with a control period. The matched cohort study was used to determine the increased risk that COVID-19 confers compared with the background population of increased acute myocardial infarction or ischaemic stroke in the first 2 weeks following COVID-19.\n\n86 742 patients with COVID-19 were included in the SCCS study, and 348 481 matched control individuals were also included in the matched cohort study. When day of exposure was excluded from the risk period in the SCCS, the IRR for acute myocardial infarction was 2\u00b789 (95% CI 1\u00b751-5\u00b755) for the first week, 2\u00b753 (1\u00b729-4\u00b794) for the second week, and 1\u00b760 (0\u00b784-3\u00b704) in weeks 3 and 4 following COVID-19. When day of exposure was included in the risk period, IRR was 8\u00b744 (5\u00b745-13\u00b708) for the first week, 2\u00b756 (1\u00b731-5\u00b701) for the second week, and 1\u00b762 (0\u00b785-3\u00b709) for weeks 3 and 4 following COVID-19. The corresponding IRRs for ischaemic stroke when day of exposure was excluded from the risk period were 2\u00b797 (1\u00b771-5\u00b715) in the first week, 2\u00b780 (1\u00b760-4\u00b788) in the second week, and 2\u00b710 (1\u00b733-3\u00b732) in weeks 3 and 4 following COVID-19; when day of exposure was included in the risk period, the IRRs were 6\u00b718 (4\u00b706-9\u00b742) for the first week, 2\u00b785 (1\u00b764-4\u00b797) for the second week, and 2\u00b714 (1\u00b736-3\u00b738) for weeks 3 and 4 following COVID-19. In the matched cohort analysis excluding day 0, the odds ratio (OR) for acute myocardial infarction was 3\u00b741 (1\u00b758-7\u00b736) and for stroke was 3\u00b763 (1\u00b769-7\u00b780) in the 2 weeks following COVID-19. When day 0 was included in the matched cohort study, the OR for acute myocardial infarction was 6\u00b761 (3\u00b756-12\u00b720) and for ischaemic stroke was 6\u00b774 (3\u00b771-12\u00b720) in the 2 weeks following COVID-19.\n\nOur findings suggest that COVID-19 is a risk factor for acute myocardial infarction and ischaemic stroke. This indicates that acute myocardial infarction and ischaemic stroke represent a part of the clinical picture of COVID-19, and highlights the need for vaccination against COVID-19.\n\nCentral ALF-funding and Base Unit ALF-Funding, Region V\u00e4sterbotten, Sweden; Strategic funding during 2020 from the Department of Clinical Microbiology, Ume\u00e5 University, Sweden; Stroke Research in Northern Sweden; The Laboratory for Molecular Infection Medicine Sweden.", "doi": "10.1016/S0140-6736(21)00896-5", "pmid": "34332652", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8321431"}, {"db": "pii", "key": "S0140-6736(21)00896-5"}], "notes": [], "created": "2021-08-04T17:01:26.792Z", "modified": "2023-07-13T11:26:15.336Z"}, {"entity": "publication", "iuid": "76ce0eac73b046a3b39f4ca61d43e623", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76ce0eac73b046a3b39f4ca61d43e623.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76ce0eac73b046a3b39f4ca61d43e623"}}, "title": "The impact of first and second wave of COVID-19 on knee and hip surgeries in Sweden.", "authors": [{"family": "Dell'Isola", "given": "Andrea", "initials": "A", "orcid": "0000-0002-0319-458X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d8ea417b7c447f8bc4da9f47f9feb39.json"}}, {"family": "Kiadaliri", "given": "Ali", "initials": "A"}, {"family": "Turkiewicz", "given": "Aleksandra", "initials": "A"}, {"family": "Hughes", "given": "Velocity", "initials": "V"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}, {"family": "Runhaar", "given": "Jos", "initials": "J"}, {"family": "Bierma-Zeinstra", "given": "Sita", "initials": "S"}, {"family": "Englund", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2021-08-13", "journal": {"title": "J Exp Orthop", "issn": "2197-1153", "volume": "8", "issue": "1", "pages": "60", "issn-l": null}, "abstract": "To investigate the impact of COVID-19 in Sweden on rates of knee and hip surgeries.\n\nWe used healthcare data for the population of the southernmost region in Sweden (1.4 million inhabitants). We did an interrupted time-series analysis to estimate changes in rates and trends of joint replacements (JR), arthroscopies, and fracture surgeries for knee or hip in April-December 2020 compared to pre-COVID-19 levels adjusting for seasonal variations.\n\nWe found a drop of 54% (95% CI 42%; 68%) and 42% (95% CI 32%; 52%), respectively, in the rate of JRs and arthroscopies in April 2020 when compared to the counterfactual scenario. This was followed by an increase that brought the rates of JRs and arthroscopies back to their predicted levels also during the beginning of the second wave (November-December 2020). Acute fracture surgeries were largely unaffected, i.e. did not show any decrease as observed for the other surgeries.\n\nIn southern Sweden, we observed a marked decrease in elective knee and hip surgeries following the first wave of Covid-19. The rates remained close to normal during the beginning of the second wave suggesting that important elective surgeries for patients with end-stage osteoarthritis can still be offered despite an ongoing pandemic provided adequate routines and hospital resources.", "doi": "10.1186/s40634-021-00382-7", "pmid": "34389919", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s40634-021-00382-7"}], "notes": [], "created": "2021-08-16T09:31:35.898Z", "modified": "2021-08-16T09:31:35.951Z"}, {"entity": "publication", "iuid": "1093e74c258e4557b0c0b7cf5b9a8ebf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1093e74c258e4557b0c0b7cf5b9a8ebf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1093e74c258e4557b0c0b7cf5b9a8ebf"}}, "title": "Patterns of prescription dispensation and over-the-counter medication sales in Sweden during the COVID-19 pandemic.", "authors": [{"family": "Karlsson", "given": "P\u00e4r", "initials": "P"}, {"family": "Nakitanda", "given": "Aya Olivia", "initials": "AO"}, {"family": "L\u00f6fling", "given": "Lukas", "initials": "L", "orcid": "0000-0002-2731-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/791065e777f04244b251fb5a167cf33f.json"}}, {"family": "Cesta", "given": "Carolyn E", "initials": "CE", "orcid": "0000-0001-5759-9366", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd628fbbf6614769a1d8ad40b78b8093.json"}}], "type": "journal article", "published": "2021-08-13", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "8", "pages": "e0253944", "issn-l": "1932-6203"}, "abstract": "On February 26th 2020, a high alert was issued in Sweden in response to the diagnosis of the first few coronavirus disease 2019 (COVID-19) cases in the country. Subsequently, a decreased supply of essential goods, including medical products, was anticipated. We aimed to explore the weekly patterns of prescription dispensing and over-the-counter (OTC) medication sales in Sweden in 2020 compared with previous years, to assess the influence of the government restrictions on medication sales, and to assess whether there is evidence of medication stockpiling in the population.\n\nAggregated data on the weekly volume of defined daily doses (DDDs) of prescription medication dispensed and OTC sales from 2015 to 2020 were examined. From 2015-2019 data, the predicted weekly volume of DDDs for 2020 was estimated and compared to the observed volume for each ATC anatomical main group and therapeutic subgroup.\n\nFrom mid-February to mid-March 2020, there were increases in the weekly volumes of dispensed medication, peaking in the second week of March with a 46% increase in the observed versus predicted number of DDDs dispensed (16,440 vs 11,260 DDDs per 1000 inhabitants). A similar pattern was found in all age groups, in both sexes, and across metropolitan and non-metropolitan regions. In the same week in March, there was a 96% increase in the volume of OTC sold (2,504 vs 1,277 DDDs per 1000 inhabitants), specifically in ATC therapeutic subgroups including vitamins, antipyretics, painkillers, and nasal, throat, cough and cold preparations.\n\nBeginning in mid-February 2020, there were significant changes in the volume of prescription medication dispensed and OTC drugs sold. The weekly volume of DDDs quickly decreased following recommendations from public authorities. Overall, our findings suggest stockpiling behavior over a surge in new users of medication.", "doi": "10.1371/journal.pone.0253944", "pmid": "34388166", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-06619"}], "notes": [], "created": "2021-08-16T09:23:40.853Z", "modified": "2021-08-16T09:23:40.907Z"}, {"entity": "publication", "iuid": "762adfb81a5b46adadce0d32a76d9bfd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/762adfb81a5b46adadce0d32a76d9bfd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/762adfb81a5b46adadce0d32a76d9bfd"}}, "title": "Genetic-based adaptive momentum estimation for predicting mortality risk factors for COVID-19 patients using deep learning.", "authors": [{"family": "Elghamrawy", "given": "Sally M", "initials": "SM", "orcid": "0000-0002-5430-390X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed6eb2f2b245401b8ad977256a3e918d.json"}}, {"family": "Hassanien", "given": "Aboul Ella", "initials": "AE", "orcid": "0000-0002-9989-6681", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28d8d8edeb454ee78721318261a3f18c.json"}}, {"family": "Vasilakos", "given": "Athanasios V", "initials": "AV", "orcid": "0000-0003-1902-9877", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3315b301bfc45188d847998d929de44.json"}}], "type": "journal article", "published": "2021-08-13", "journal": {"title": "Int J Imaging Syst Technol", "issn": "0899-9457", "issn-l": null}, "abstract": "The mortality risk factors for coronavirus disease (COVID-19) must be early predicted, especially for severe cases, to provide intensive care before they develop to critically ill immediately. This paper aims to develop an optimized convolution neural network (CNN) for predicting mortality risk factors for COVID-19 patients. The proposed model supports two types of input data clinical variables and the computed tomography (CT) scans. The features are extracted from the optimized CNN phase and then applied to the classification phase. The CNN model's hyperparameters were optimized using a proposed genetic-based adaptive momentum estimation (GB-ADAM) algorithm. The GB-ADAM algorithm employs the genetic algorithm (GA) to optimize Adam optimizer's configuration parameters, consequently improving the classification accuracy. The model is validated using three recent cohorts from New York, Mexico, and Wuhan, consisting of 3055, 7497,504 patients, respectively. The results indicated that the most significant mortality risk factors are: CD T Lymphocyte (Count), D-dimer greater than 1 Ug/ml, high values of lactate dehydrogenase (LDH), C-reactive protein (CRP), hypertension, and diabetes. Early identification of these factors would help the clinicians in providing immediate care. The results also show that the most frequent COVID-19 signs in CT scans included ground-glass opacity (GGO), followed by crazy-paving pattern, consolidations, and the number of lobes. Moreover, the experimental results show encouraging performance for the proposed model compared with different predicting models. 8 +", "doi": "10.1002/ima.22644", "pmid": "34518740", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "IMA22644"}, {"db": "pmc", "key": "PMC8426801"}], "notes": [], "created": "2021-09-20T06:28:02.045Z", "modified": "2021-09-20T06:28:17.272Z"}, {"entity": "publication", "iuid": "c3f75996c34f458d839411152ca3bb3f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3f75996c34f458d839411152ca3bb3f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3f75996c34f458d839411152ca3bb3f"}}, "title": "COVID-19 vaccine uptake among older people in relation to sociodemographic factors \u2013cohort results from southern Sweden", "authors": [{"family": "Inghammar", "given": "Malin", "initials": "M", "orcid": "0000-0003-2995-1312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4ab710428614cccb2a537ecab31d0a0.json"}}, {"family": "Moghaddassi", "given": "Mahnaz", "initials": "M", "orcid": "0000-0002-0844-4736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a219bde5ba8a4f3f8655ada08d749885.json"}}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}, {"family": "Malmqvist", "given": "Ulf", "initials": "U"}, {"family": "Kahn", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-5566-6350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42eda71f3775400599febc10a4e7359c.json"}}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J", "orcid": "0000-0003-1883-2000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e88fdca336ae41c891f0a46e2481b67f.json"}}], "type": "posted-content", "published": "2021-08-13", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.08.12.21261981", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-08-16T11:25:49.928Z", "modified": "2021-11-29T06:15:40.860Z"}, {"entity": "publication", "iuid": "097f0660da62413b87a2a1e5b5db78de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/097f0660da62413b87a2a1e5b5db78de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/097f0660da62413b87a2a1e5b5db78de"}}, "title": "Applications of Artificial Intelligence, Machine Learning, Big Data and the Internet of Things to the COVID-19 Pandemic: A Scientometric Review Using Text Mining.", "authors": [{"family": "Rodr\u00edguez-Rodr\u00edguez", "given": "Ignacio", "initials": "I", "orcid": "0000-0002-0118-3406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7dade1cd1ba4f55b4851886236a8f2f.json"}}, {"family": "Rodr\u00edguez", "given": "Jos\u00e9-V\u00edctor", "initials": "JV", "orcid": "0000-0002-3298-6439", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1fa087057b0d4db88f835464f5236c24.json"}}, {"family": "Shirvanizadeh", "given": "Niloofar", "initials": "N"}, {"family": "Ortiz", "given": "Andr\u00e9s", "initials": "A", "orcid": "0000-0003-2690-1926", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49783f8986ae4250b181ee1a68c3df35.json"}}, {"family": "Pardo-Quiles", "given": "Domingo-Javier", "initials": "DJ", "orcid": "0000-0003-3240-2568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/334b10db57e745928464250074151e78.json"}}], "type": "journal article", "published": "2021-08-13", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "16", "issn-l": null}, "abstract": "The COVID-19 pandemic has wreaked havoc in every country in the world, with serious health-related, economic, and social consequences. Since its outbreak in March 2020, many researchers from different fields have joined forces to provide a wide range of solutions, and the support for this work from artificial intelligence (AI) and other emerging concepts linked to intelligent data analysis has been decisive. The enormous amount of research and the high number of publications during this period makes it difficult to obtain an overall view of the different applications of AI to the management of COVID-19 and an understanding of how research in this field has been evolving. Therefore, in this paper, we carry out a scientometric analysis of this area supported by text mining, including a review of 18,955 publications related to AI and COVID-19 from the Scopus database from March 2020 to June 2021 inclusive. For this purpose, we used VOSviewer software, which was developed by researchers at Leiden University in the Netherlands. This allowed us to examine the exponential growth in research on this issue and its distribution by country, and to highlight the clear hegemony of the United States (USA) and China in this respect. We used an automatic process to extract topics of research interest and observed that the most important current lines of research focused on patient-based solutions. We also identified the most relevant journals in terms of the COVID-19 pandemic, demonstrated the growing value of open-access publication, and highlighted the most influential authors by means of an analysis of citations and co-citations. This study provides an overview of the current status of research on the application of AI to the pandemic.", "doi": "10.3390/ijerph18168578", "pmid": "34444327", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijerph18168578"}, {"db": "pmc", "key": "PMC8393243"}], "notes": [], "created": "2021-09-01T07:26:54.980Z", "modified": "2021-09-01T07:26:55.090Z"}, {"entity": "publication", "iuid": "c92743112e0b41f9b2e3e36932da3580", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c92743112e0b41f9b2e3e36932da3580.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c92743112e0b41f9b2e3e36932da3580"}}, "title": "Neutralization of VOCs including Delta one year post COVID-19 or vaccine", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Ng", "given": "Henry", "initials": "H"}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Lindbo", "given": "Sarah", "initials": "S"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "posted-content", "published": "2021-08-12", "journal": {"title": "MedRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.08.12.21261951", "pmid": null, "labels": {"Type: Preprint": null, "Research Area: Host cell systems biology and targets": null, "Research Area: Drug discovery and repurposing of drugs": null, "Category: Biochemistry": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Research Area: High-throughput and high-content serology": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-08-16T11:27:28.128Z", "modified": "2023-06-19T14:28:25.881Z"}, {"entity": "publication", "iuid": "39de810995674ece9f905bd11df5bd41", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/39de810995674ece9f905bd11df5bd41.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/39de810995674ece9f905bd11df5bd41"}}, "title": "Low mortality rates among critically-ill adults with COVID-19 at three non-academic intensive care units in south Sweden.", "authors": [{"family": "Taxbro", "given": "Knut", "initials": "K", "orcid": "0000-0001-8711-9044", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53d41b4a81184f4da24af4065e0371e1.json"}}, {"family": "Granath", "given": "Andreas", "initials": "A"}, {"family": "Sunnergren", "given": "Ola", "initials": "O"}, {"family": "Seifert", "given": "Stefanie", "initials": "S"}, {"family": "Jakubczyk", "given": "Milena N", "initials": "MN"}, {"family": "Persson", "given": "Magnus", "initials": "M"}, {"family": "Hammarskj\u00f6ld", "given": "Anneli", "initials": "A"}, {"family": "Alkemark", "given": "Catarina", "initials": "C"}, {"family": "Hammarskj\u00f6ld", "given": "Fredrik", "initials": "F"}, {"family": "RJL COVID-19 research group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-08-12", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172"}, "abstract": "The COVID-19 pandemic has put an exceptional strain on intensive care units worldwide. During the first year, the survival of patients with acute hypoxaemic respiratory failure appears to have improved. We aimed to describe the mortality rates, management characteristics, and two pandemic waves during the first year at three non-academic rural intensive care units in Sweden.\n\nWe retrospectively analysed all cases of COVID-19 admitted to intensive care units in Region J\u00f6nk\u00f6ping County during one year. The primary endpoint was 30-day mortality.\n\nBetween 14th March 2020 and 13th March 2021, two-hundred and sixty-four patients were admitted to undergo intensive care with confirmed SARS-CoV-2 infection. The 30-day mortality rate after the initial intensive care admission was 12.9%, and this rate remained unchanged during both pandemic waves. However, we found several distinct differences between the two pandemic waves, including an increase in the use of high-flow nasal oxygen but a decrease in invasive mechanical ventilation use, biochemical markers of inflammation, continuous renal replacement therapy, and length of stay in the intensive care unit.\n\nOur study showed that critically ill patients with COVID-19 in Sweden have a low 30-day mortality rate which compares well with results published from academic centres and national cohorts throughout Scandinavia. During the second pandemic wave, the proportion of patients receiving invasive mechanical ventilation and continuous renal replacement therapy was lower than that in the first wave. This could be the result of increased knowledge and improved therapeutic options.", "doi": "10.1111/aas.13972", "pmid": "34386972", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-16T09:24:31.418Z", "modified": "2021-08-16T09:24:31.457Z"}, {"entity": "publication", "iuid": "a6742f8afc5b48b3897d5ef91387d725", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6742f8afc5b48b3897d5ef91387d725.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6742f8afc5b48b3897d5ef91387d725"}}, "title": "Air pollution and COVID-19: clearing the air and charting a post-pandemic course: a joint workshop report of ERS, ISEE, HEI and WHO", "authors": [{"family": "Andersen", "given": "Zorana J", "initials": "ZJ"}, {"family": "Hoffmann", "given": "Barbara", "initials": "B"}, {"family": "Morawska", "given": "Lidia", "initials": "L"}, {"family": "Adams", "given": "Martin", "initials": "M"}, {"family": "Furman", "given": "Eeva", "initials": "E"}, {"family": "Yorgancioglu", "given": "Arzu", "initials": "A"}, {"family": "Greenbaum", "given": "Dan", "initials": "D"}, {"family": "Neira", "given": "Maria", "initials": "M"}, {"family": "Brunekreef", "given": "Bert", "initials": "B"}, {"family": "Forastiere", "given": "Francesco", "initials": "F"}, {"family": "Rice", "given": "Mary B", "initials": "MB", "orcid": "0000-0003-2538-391X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b3b44173ee84de8bde4fe34352e40c3.json"}}, {"family": "Wakenhut", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Coleen", "given": "Erika", "initials": "E"}, {"family": "Boogaard", "given": "Hanna", "initials": "H"}, {"family": "Gehring", "given": "Ulrike", "initials": "U"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E", "orcid": "0000-0002-8248-0663", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58e96082947e4752a23f322e42754097.json"}}, {"family": "Ward", "given": "Brian", "initials": "B"}, {"family": "De Matteis", "given": "Sara", "initials": "S"}], "type": "journal-article", "published": "2021-08-12", "journal": {"title": "Eur Respir J", "issn": "0903-1936", "pages": "2101063", "issn-l": null}, "abstract": null, "doi": "10.1183/13993003.01063-2021", "pmid": null, "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-13T12:02:19.682Z", "modified": "2021-08-13T12:02:19.748Z"}, {"entity": "publication", "iuid": "8459545312984087acc8365e1a3b8290", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8459545312984087acc8365e1a3b8290.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8459545312984087acc8365e1a3b8290"}}, "title": "Post-Covid-19 Tachycardia Syndrome: A distinct phenotype of Post-acute Covid-19 Syndrome.", "authors": [{"family": "St\u00e5hlberg", "given": "Marcus", "initials": "M"}, {"family": "Reistam", "given": "Ulrika", "initials": "U"}, {"family": "Fedorowski", "given": "Artur", "initials": "A"}, {"family": "Villacorta", "given": "Humberto", "initials": "H"}, {"family": "Horiuchi", "given": "Yu", "initials": "Y"}, {"family": "Bax", "given": "Jeroen", "initials": "J"}, {"family": "Pitt", "given": "Bertram", "initials": "B"}, {"family": "Matskeplishvili", "given": "Simon", "initials": "S"}, {"family": "L\u00fcscher", "given": "Thomas F", "initials": "TF"}, {"family": "Weichert", "given": "Immo", "initials": "I"}, {"family": "Thani", "given": "Khalid Bin", "initials": "KB"}, {"family": "Maisel", "given": "Alan", "initials": "A"}], "type": "journal article", "published": "2021-08-11", "journal": {"title": "Am J Med", "issn": "1555-7162", "issn-l": null}, "abstract": "In this paper we highlight the presence of tachycardia in Post-acute Covid-19 Syndrome by introducing a new label for this phenomenon: Post-covid-19 tachycardia syndrome and argue that this constitutes a phenotype or sub-syndrome in PACS. We also discuss epidemiology, putative mechanisms, treatment options and future research directions in this novel clinical syndrome.", "doi": "10.1016/j.amjmed.2021.07.004", "pmid": "34390682", "labels": {"Type: Review": null, "Category: Post-COVID": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0002-9343(21)00472-1"}], "notes": [], "created": "2021-08-16T09:19:42.823Z", "modified": "2021-08-16T09:19:42.827Z"}, {"entity": "publication", "iuid": "662c8a91e61245ef9e66193caf062884", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/662c8a91e61245ef9e66193caf062884.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/662c8a91e61245ef9e66193caf062884"}}, "title": "Ovulatory upregulation of angiotensin-converting enzyme 2, a receptor for SARS-CoV-2, in dominant follicles of the human ovary.", "authors": [{"family": "Choi", "given": "Yohan", "initials": "Y"}, {"family": "Jeon", "given": "Hayce", "initials": "H"}, {"family": "Br\u00e4nnstr\u00f6m", "given": "Mats", "initials": "M"}, {"family": "Akin", "given": "James W", "initials": "JW"}, {"family": "Curry", "given": "Thomas E", "initials": "TE"}, {"family": "Jo", "given": "Misung", "initials": "M"}], "type": "journal article", "published": "2021-08-11", "journal": {"title": "Fertil Steril", "issn": "1556-5653", "issn-l": null}, "abstract": "To determine the temporal expression of angiotensin-converting enzyme 2 (ACE2), a receptor for SARS-CoV-2, in dominant follicles throughout the periovulatory period in women and the regulatory mechanisms underlying ACE2 expression in human granulosa/lutein cells (hGLC).\n\nExperimental prospective clinical study and laboratory-based investigation.\n\nUniversity Medical Center and private in vitro fertilization center.\n\nThirty premenopausal women undergoing surgery for tubal ligation and 16 premenopausal women undergoing in vitro fertilization.\n\nAdministration of human chorionic gonadotropin (hCG) and harvesting of preovulatory/ovulatory follicles by timed laparoscopy, and collection of granulosa/lutein cells and cumulus cells at the time of oocyte retrieval.\n\nExpression and localization of ACE2 in granulosa cells and dominant follicles collected throughout the periovulatory period of the menstrual cycle and in hGLC using quantitative polymerase chain reaction, immunoblotting, and immunohistochemistry.\n\nACE2 expression (mRNA and protein) is up-regulated in human ovulatory follicles after administration of hCG. ACE2 expression was higher in cumulus cells than in granulosa cells. hCG increased the expression of ACE2 in primary hGLC cultures; the increase was inhibited by RU486 (an antagonist for progesterone receptor and glucocorticoid receptor) and CORT125281 (a selective glucocorticoid receptor antagonist), but not by AG1478 (an EGF receptor tyrosine kinase inhibitor) or by dexamethasone.\n\nThe hormone-regulated expression of ACE2 in granulosa cells suggests a potential role of ACE2 in the ovulatory process. These data also imply the possible impact of COVID-19 on a vital cyclic event of ovarian function and thus on women's overall reproductive health. However, SAR-CoV-2 infection in ovarian cells in vivo or in vitro has yet to be determined.", "doi": "10.1016/j.fertnstert.2021.08.009", "pmid": "34538460", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0015-0282(21)01932-4"}, {"db": "pmc", "key": "PMC8354803"}], "notes": [], "created": "2021-10-10T15:33:54.875Z", "modified": "2021-10-10T15:33:54.901Z"}, {"entity": "publication", "iuid": "e429c397680849fa8fb8e42ec170e9a7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e429c397680849fa8fb8e42ec170e9a7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e429c397680849fa8fb8e42ec170e9a7"}}, "title": "Healthcare professionals' experiences during the initial stage of the COVID-19 pandemic in the intensive care unit: A qualitative study.", "authors": [{"family": "Mortensen", "given": "Camilla Bekker", "initials": "CB"}, {"family": "Zachodnik", "given": "Josephine", "initials": "J"}, {"family": "Caspersen", "given": "Sidsel Fjordbak", "initials": "SF"}, {"family": "Geisler", "given": "Anja", "initials": "A"}], "type": "journal article", "published": "2021-08-11", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "pages": "103130", "issn-l": null}, "abstract": "The COVID-19 pandemic called for rapidly considerable changes in the healthcare system. Healthcare professionals from different departments within the hospital settings were enrolled in the emergency preparedness. This study, therefore, aimed to explore the healthcare professionals' experiences attending the ICU-preparedness and caring for patients with COVID-19 during the initial stage of the pandemic.\n\nA descriptive explorative qualitative study was conducted by interviewing healthcare professionals during spring 2020, exploring their experiences as part of the ICU-preparedness team and caring for patients with COVID-19 in the ICU. Healthcare professionals from different departments were recruited by purposive sampling. The interviews were transcribed verbatim and analysed using content analysis.\n\nSixteen nurses and four physicians from a university hospital in Denmark participated. The analysis revealed three main themes and eight sub-themes. The main themes were (1) Professionalism in work-life (adaption, the patient's welfare, insecurity, and security), (2) Community Spirit (responsibility and contribution), and (3) Institutional organisation (the role of management, loss of freedom, and information).\n\nDespite work specialities and professions, the participants reported a uniformity of similar experiences of uncertainties, but also a sense of community arose during the first phase of COVID-19.\n\nTo ensure resilience and mental health, and well-being for the healthcare professionals, comprehensive support should be provided. Guidelines for interventions and training are necessary to promote preparedness and reduce psychological stress.", "doi": "10.1016/j.iccn.2021.103130", "pmid": "34538544", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(21)00119-1"}, {"db": "pmc", "key": "PMC8354791"}], "notes": [], "created": "2021-10-10T15:34:21.827Z", "modified": "2021-10-10T15:34:21.840Z"}, {"entity": "publication", "iuid": "3bda20886f3740a59941eacb08330d9a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3bda20886f3740a59941eacb08330d9a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3bda20886f3740a59941eacb08330d9a"}}, "title": "Fathering Practices in Sweden During the COVID-19: Experiences of Syrian Refugee Fathers.", "authors": [{"family": "Wiss\u00f6", "given": "Ther\u00e9se", "initials": "T"}, {"family": "B\u00e4ck-Wiklund", "given": "Margareta", "initials": "M"}], "type": "journal article", "published": "2021-08-11", "journal": {"title": "Front Sociol", "issn": "2297-7775", "issn-l": null, "volume": "6", "issue": null, "pages": "721881"}, "abstract": "This article explores fathering practices among Syrian refugee families in Sweden. Syrian refugees provide an example of people who migrated because of a single major event: the war in Syria. The article examines the impact of the COVID-19 pandemic on fathering practices. The Swedish COVID-19 strategy differed from those adopted in many other countries. Lockdowns were minimal and were not stringently enforced, based on the assumption that individuals would trust the authorities and would take personal responsibility for complying with their guidelines and recommendations. Previous research suggests that migrants and other vulnerable groups were not always well informed about the public policies introduced prior to and during the pandemic. The article draws on empirical data from a wider research project on the family lives of Syrian migrants in Sweden. The authors present their findings from an analysis of eleven ethnographically informed semi-structured interviews, carried out before and during the pandemic, with married fathers who had been living in Sweden for several years. In this article, they focus on three cases representing fathers with varied educational backgrounds and employment histories. These families had in common what are considered by Swedish standards to be overcrowded living conditions; they were forced to accept close family proximity, both physically and emotionally, as they no longer had the supportive networks they were used to in Syria. The three fathers were found to rely more heavily on information provided by the people with whom they were in contact in Sweden than on policies and recommendations from the authorities. These findings confirmed that the previous experiences among refugees of shifting policies regarding migration and integration had lowered their trust in government. They had learnt that they needed to rely on mutual dependency not only between spouses, but also between parents and children.", "doi": "10.3389/fsoc.2021.721881", "pmid": "34458362", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "721881"}, {"db": "pmc", "key": "PMC8385311"}], "notes": [], "created": "2021-09-01T07:47:01.167Z", "modified": "2022-11-23T08:53:49.788Z"}, {"entity": "publication", "iuid": "63111781bc1e427aa45a890921711381", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63111781bc1e427aa45a890921711381.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63111781bc1e427aa45a890921711381"}}, "title": "Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling.", "authors": [{"family": "Mishra", "given": "Swapnil", "initials": "S", "orcid": "0000-0002-8759-5902", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9090a94ef6b43e59561319e56b1fcc8.json"}}, {"family": "Scott", "given": "James A", "initials": "JA"}, {"family": "Laydon", "given": "Daniel J", "initials": "DJ", "orcid": "0000-0003-4270-3321", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/941e87bd83ed4474869d63d345cf8ff4.json"}}, {"family": "Flaxman", "given": "Seth", "initials": "S"}, {"family": "Gandy", "given": "Axel", "initials": "A"}, {"family": "Mellan", "given": "Thomas A", "initials": "TA"}, {"family": "Unwin", "given": "H Juliette T", "initials": "HJT", "orcid": "0000-0002-9120-4003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29efd6265a564f1890678af46df4ab5e.json"}}, {"family": "Vollmer", "given": "Michaela", "initials": "M"}, {"family": "Coupland", "given": "Helen", "initials": "H"}, {"family": "Ratmann", "given": "Oliver", "initials": "O"}, {"family": "Monod", "given": "Melodie", "initials": "M"}, {"family": "Zhu", "given": "Harrison H", "initials": "HH"}, {"family": "Cori", "given": "Anne", "initials": "A"}, {"family": "Gaythorpe", "given": "Katy A M", "initials": "KAM", "orcid": "0000-0003-3734-9081", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/faae9aff1d7c4b948de39fce64a55bc3.json"}}, {"family": "Whittles", "given": "Lilith K", "initials": "LK", "orcid": "0000-0002-8913-0391", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4635744009424fb5b72184abad9929ff.json"}}, {"family": "Whittaker", "given": "Charles", "initials": "C"}, {"family": "Donnelly", "given": "Christl A", "initials": "CA", "orcid": "0000-0002-0195-2463", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5e672e1b59c4d9c8d6c5ba3e5280dd9.json"}}, {"family": "Ferguson", "given": "Neil M", "initials": "NM", "orcid": "0000-0002-1154-8093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34d57563a33a4be7be974488684afbb7.json"}}, {"family": "Bhatt", "given": "Samir", "initials": "S"}], "type": "comparative study", "published": "2021-08-11", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "16342", "issn-l": "2045-2322"}, "abstract": "The UK and Sweden have among the worst per-capita COVID-19 mortality in Europe. Sweden stands out for its greater reliance on voluntary, rather than mandatory, control measures. We explore how the timing and effectiveness of control measures in the UK, Sweden and Denmark shaped COVID-19 mortality in each country, using a counterfactual assessment: what would the impact have been, had each country adopted the others' policies? Using a Bayesian semi-mechanistic model without prior assumptions on the mechanism or effectiveness of interventions, we estimate the time-varying reproduction number for the UK, Sweden and Denmark from daily mortality data. We use two approaches to evaluate counterfactuals which transpose the transmission profile from one country onto another, in each country's first wave from 13th March (when stringent interventions began) until 1st July 2020. UK mortality would have approximately doubled had Swedish policy been adopted, while Swedish mortality would have more than halved had Sweden adopted UK or Danish strategies. Danish policies were most effective, although differences between the UK and Denmark were significant for one counterfactual approach only. Our analysis shows that small changes in the timing or effectiveness of interventions have disproportionately large effects on total mortality within a rapidly growing epidemic.", "doi": "10.1038/s41598-021-95699-9", "pmid": "34381102", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8358009"}, {"db": "pii", "key": "10.1038/s41598-021-95699-9"}], "notes": [], "created": "2023-01-13T13:42:29.507Z", "modified": "2023-01-13T13:42:29.715Z"}, {"entity": "publication", "iuid": "b476270647504837acd317ffe5bf0994", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b476270647504837acd317ffe5bf0994.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b476270647504837acd317ffe5bf0994"}}, "title": "Soft law and individual responsibility: a review of the Swedish policy response to COVID-19.", "authors": [{"family": "Winblad", "given": "Ulrika", "initials": "U", "orcid": "0000-0002-3921-5522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af163cdcd01e4e348be01c344085ef2e.json"}}, {"family": "Swenning", "given": "Anna-Karin", "initials": "A"}, {"family": "Spangler", "given": "Douglas", "initials": "D"}], "type": "journal article", "published": "2021-08-10", "journal": {"title": "Health Econ Policy Law", "issn": "1744-134X", "issn-l": null, "volume": null, "issue": null, "pages": "1-14"}, "abstract": "Sweden's coronavirus disease 2019 (COVID-19) response, initially based largely on voluntary measures, has evoked strong reactions nationally and internationally. In this study, we describe Sweden's national policy response with regard to the general public, the community and the health care system, with a focus on how the response changed from March 2020 to June 2021. A number of factors contributed to Sweden's choice of policy response, including its existing legal framework, independent expert agencies and its decentralized, multi-level health care governance system. Challenges to the health- and elder care system during the pandemic, such as the need to increase intensive care- and testing capacity, and to ensure the safety of the elderly were addressed largely at the regional and local levels, with national authorities assuming a primarily coordinative role. Although the overall response based on voluntary compliance has persisted, the national government started to take a more prominent role in public messaging, and in enacting legally binding restrictions during subsequent waves of the pandemic. This study illustrates that not only policy responses, but also the fundamental structure of the health- and elder care system and its governance should be considered when evaluating the impact of the COVID-19 pandemic.", "doi": "10.1017/S1744133121000256", "pmid": "34372959", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1744133121000256"}, {"db": "pmc", "key": "PMC8387683"}], "notes": [], "created": "2021-08-11T14:30:17.809Z", "modified": "2021-11-18T13:32:02.858Z"}, {"entity": "publication", "iuid": "ad4e8a3cf6f241cb964898f14cfba40b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ad4e8a3cf6f241cb964898f14cfba40b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ad4e8a3cf6f241cb964898f14cfba40b"}}, "title": "Remdesivir in the COVID-19 Pandemic: An Analysis of Spontaneous Reports in VigiBase During 2020.", "authors": [{"family": "Rocca", "given": "Elena", "initials": "E"}, {"family": "Gauffin", "given": "Oskar", "initials": "O"}, {"family": "Savage", "given": "Ruth", "initials": "R"}, {"family": "Vidlin", "given": "Sara Hedfors", "initials": "SH"}, {"family": "Grundmark", "given": "Birgitta", "initials": "B", "orcid": "0000-0002-2799-9374", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af41b5a50729439f9ee9454393af8cdc.json"}}], "type": "journal article", "published": "2021-08-10", "journal": {"title": "Drug Saf", "issn": "1179-1942", "issn-l": "0114-5916"}, "abstract": "The safety profile of remdesivir, conditionally approved for COVID-19, was limited at its 2020 introduction. Adverse drug reactions (ADRs) for medicines are collected in VigiBase, the WHO Global Database of Individual Case Safety Reports (ICSRs).\n\nThis study aimed to provide a descriptive analysis of COVID-19 ICSR data focusing on remdesivir, including a disproportionality analysis (DA) of ADRs.\n\nA dedicated algorithm enabled retrieval of all COVID-19 treatment-specific ICSRs. A severity algorithm based on co-reported medicines and symptoms enabled selection of tocilizumab with its well established safety profile as comparator for remdesivir. Descriptive statistics were used for general ICSR demographics for all COVID-19-specific medicines, remdesivir and tocilizumab individually and furthermore to present treatment patterns of medicines co-reported with remdesivir. A COVID-19 indication-focused DA was deployed to minimize confounding from underlying polysymptomatic disease.\n\n14,574 COVID-19-related ICSRs were entered into VigiBase during 2020. Remdesivir was the most common medicine reported. Of 4944 remdesivir ICSRs, where tocilizumab was not co-reported, 93% described remdesivir as the sole suspect medicine. Sixty percent of ICSRs concerned males, median age was 63 years and the majority originated from the Americas (72%). In 1089 (21%) of remdesivir ICSRs, data indicated severe/critical disease. Co-reported medicines peaked during the first 3 days of remdesivir treatment. The DA for the established tocilizumab and the new remdesivir were mainly in line with the safety profiles for both medicines but suggested new safety concerns. The most reported ADRs for remdesivir represented liver dysfunction, kidney injury, death and bradycardia.\n\nGlobal COVID-19-related ADR reporting proved useful in providing information on ADRs as well as on treatment patterns in this patient group. Indication-focused disproportionality analysis, together with the use of a comparator with a known safety profile, proved effective in identifying known safety information and suggested new safety concerns for remdesivir.", "doi": "10.1007/s40264-021-01091-x", "pmid": "34374967", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40264-021-01091-x"}], "notes": [], "created": "2021-08-11T14:28:49.961Z", "modified": "2021-08-11T14:29:37.634Z"}, {"entity": "publication", "iuid": "594d9547784441abb908eeaf85ed0e79", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/594d9547784441abb908eeaf85ed0e79.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/594d9547784441abb908eeaf85ed0e79"}}, "title": "Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites.", "authors": [{"family": "Hoffmann", "given": "David", "initials": "D"}, {"family": "Mereiter", "given": "Stefan", "initials": "S"}, {"family": "Jin Oh", "given": "Yoo", "initials": "Y"}, {"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Elder", "given": "Elizabeth", "initials": "E"}, {"family": "Zhu", "given": "Rong", "initials": "R"}, {"family": "Canena", "given": "Daniel", "initials": "D"}, {"family": "Hain", "given": "Lisa", "initials": "L"}, {"family": "Laurent", "given": "Elisabeth", "initials": "E"}, {"family": "Gr\u00fcnwald-Gruber", "given": "Clemens", "initials": "C"}, {"family": "Klausberger", "given": "Miriam", "initials": "M"}, {"family": "Jonsson", "given": "Gustav", "initials": "G"}, {"family": "Kellner", "given": "Max J", "initials": "MJ"}, {"family": "Novatchkova", "given": "Maria", "initials": "M"}, {"family": "Ticevic", "given": "Melita", "initials": "M"}, {"family": "Chabloz", "given": "Antoine", "initials": "A"}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G"}, {"family": "Hagelkruys", "given": "Astrid", "initials": "A"}, {"family": "Altmann", "given": "Friedrich", "initials": "F"}, {"family": "Mach", "given": "Lukas", "initials": "L"}, {"family": "Stadlmann", "given": "Johannes", "initials": "J"}, {"family": "Oostenbrink", "given": "Chris", "initials": "C"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Hinterdorfer", "given": "Peter", "initials": "P"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}], "type": "journal article", "published": "2021-08-10", "journal": {"title": "EMBO J", "issn": "1460-2075", "pages": "e108375", "issn-l": null}, "abstract": "New SARS-CoV-2 variants are continuously emerging with critical implications for therapies or vaccinations. The 22 N-glycan sites of Spike remain highly conserved among SARS-CoV-2 variants, opening an avenue for robust therapeutic intervention. Here we used a comprehensive library of mammalian carbohydrate-binding proteins (lectins) to probe critical sugar residues on the full-length trimeric Spike and the receptor binding domain (RBD) of SARS-CoV-2. Two lectins, Clec4g and CD209c, were identified to strongly bind to Spike. Clec4g and CD209c binding to Spike was dissected and visualized in real time and at single molecule resolution using atomic force microscopy. 3D modelling showed that both lectins can bind to a glycan within the RBD-ACE2 interface and thus interferes with Spike binding to cell surfaces. Importantly, Clec4g and CD209c significantly reduced SARS-CoV-2 infections. These data report the first extensive map and 3D structural modelling of lectin-Spike interactions and uncovers candidate receptors involved in Spike binding and SARS-CoV-2 infections. The capacity of CLEC4G and mCD209c lectins to block SARS-CoV-2 viral entry holds promise for pan-variant therapeutic interventions.", "doi": "10.15252/embj.2021108375", "pmid": "34375000", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://covid.molssi.org//models/#spike-protein-in-complex-with-human-ace2-spike-spike-binding%29.", "description": "Structural models for used in virtual screening"}], "notes": [], "created": "2021-08-11T14:27:59.675Z", "modified": "2021-09-09T07:13:12.326Z"}, {"entity": "publication", "iuid": "862ac2f181b7434fb4559dff0c1b0e99", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/862ac2f181b7434fb4559dff0c1b0e99.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/862ac2f181b7434fb4559dff0c1b0e99"}}, "title": "The reproductive number of the Delta variant of SARS-CoV-2 is far higher compared to the ancestral SARS-CoV-2 virus.", "authors": [{"family": "Liu", "given": "Ying", "initials": "Y"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}], "type": "journal article", "published": "2021-08-09", "journal": {"title": "J Travel Med", "issn": "1708-8305", "issn-l": null}, "abstract": "The Delta variant is now replacing all other SARS-CoV-2 variants. We found a mean R0 of 5.08 which is much higher than the R0 of the ancestral strain of 2.79. Rapidly ramping up vaccine coverage rates while enhancing public health and social measures is now even more urgent and important.", "doi": "10.1093/jtm/taab124", "pmid": "34369565", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6346388"}], "notes": [], "created": "2021-08-11T14:33:55.820Z", "modified": "2021-08-11T14:33:55.832Z"}, {"entity": "publication", "iuid": "7bd8c3c52c7a410d990755358d816fdb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7bd8c3c52c7a410d990755358d816fdb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7bd8c3c52c7a410d990755358d816fdb"}}, "title": "Initial impact of SARS-Cov-2 vaccination on healthcare workers in Italy- Update on the 28th of March 2021.", "authors": [{"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Spuri", "given": "Matteo", "initials": "M"}, {"family": "D'Ancona", "given": "Fortunato", "initials": "F"}, {"family": "Filia", "given": "Antonietta", "initials": "A"}, {"family": "Rota", "given": "Maria Cristina", "initials": "MC"}, {"family": "Petrone", "given": "Daniele", "initials": "D"}, {"family": "Vescio", "given": "Maria Fenicia", "initials": "MF"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}], "type": "journal article", "published": "2021-08-09", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null, "volume": "39", "issue": "34", "pages": "4788-4792"}, "abstract": "In Italy, the COVID-19 vaccination campaign started in December 2020 with the vaccination of healthcare workers (HCW). To analyse the real-life impact that vaccination is having on this population group, we measured the association between week of diagnosis and HCW status using log-binomial regression. By the week 22-28 March, we observed a 74% reduction (PPR 0.26; 95% CI 0.22-0.29) in the proportion of cases reported as HCW and 81% reduction in the proportion of symptomatic cases reported as HCW, compared with the week with the lowest proportion of cases among HCWs prior to the vaccination campaign (31 August-7 September). The reduction, both in relative and absolute terms, of COVID-19 cases in HCWs that started around 30 days after the start of the vaccination campaign suggest that COVID-19 vaccines are being effective in preventing infection in this group.", "doi": "10.1016/j.vaccine.2021.07.003", "pmid": "34253419", "labels": {"Category: Public Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(21)00862-8"}, {"db": "pmc", "key": "PMC8260579"}], "notes": [], "created": "2021-08-06T07:34:29.106Z", "modified": "2021-12-07T15:29:24.754Z"}, {"entity": "publication", "iuid": "d8212176c72a4096a4852c29880b2ade", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d8212176c72a4096a4852c29880b2ade.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d8212176c72a4096a4852c29880b2ade"}}, "title": "Sample-to-answer COVID-19 nucleic acid testing using a low-cost centrifugal microfluidic platform with bead-based signal enhancement and smartphone read-out.", "authors": [{"family": "Soares", "given": "Ruben R G", "initials": "RRG", "orcid": "0000-0001-5958-5232", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2fc2815bc25c4fb78df63294947ee184.json"}}, {"family": "Akhtar", "given": "Ahmad S", "initials": "AS", "orcid": "0000-0002-4560-4735", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc3276d3eaca462fb80c2033d7bc0104.json"}}, {"family": "Pinto", "given": "In\u00eas F", "initials": "IF", "orcid": "0000-0002-9714-4742", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f94e94cf2e14c3cb4ce6f8d7235ea8b.json"}}, {"family": "Lapins", "given": "Noa", "initials": "N"}, {"family": "Barrett", "given": "Donal", "initials": "D"}, {"family": "Sandh", "given": "Gustaf", "initials": "G"}, {"family": "Yin", "given": "Xiushan", "initials": "X"}, {"family": "Pelechano", "given": "Vicent", "initials": "V", "orcid": "0000-0002-9415-788X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce53b4c829e547399014c2d8042dde35.json"}}, {"family": "Russom", "given": "Aman", "initials": "A", "orcid": "0000-0002-0242-358X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a36512bc999441bfa671e316fa9e89b4.json"}}], "type": "journal article", "published": "2021-08-07", "journal": {"title": "Lab Chip", "issn": "1473-0189", "issn-l": null, "volume": "21", "issue": "15", "pages": "2932-2944"}, "abstract": "With its origin estimated around December 2019 in Wuhan, China, the ongoing SARS-CoV-2 pandemic is a major global health challenge. The demand for scalable, rapid and sensitive viral diagnostics is thus particularly pressing at present to help contain the rapid spread of infection and prevent overwhelming the capacity of health systems. While high-income countries have managed to rapidly expand diagnostic capacities, such is not the case in resource-limited settings of low- to medium-income countries. Aiming at developing cost-effective viral load detection systems for point-of-care COVID-19 diagnostics in resource-limited and resource-rich settings alike, we report the development of an integrated modular centrifugal microfluidic platform to perform loop-mediated isothermal amplification (LAMP) of viral RNA directly from heat-inactivated nasopharyngeal swab samples. The discs were pre-packed with dried n-benzyl-n-methylethanolamine modified agarose beads used to selectively remove primer dimers, inactivate the reaction post-amplification and allowing enhanced fluorescence detection via a smartphone camera. Sample-to-answer analysis within 1 hour from sample collection and a detection limit of approximately 100 RNA copies in 10 \u03bcL reaction volume were achieved. The platform was validated with a panel of 162 nasopharyngeal swab samples collected from patients with COVID-19 symptoms, providing a sensitivity of 96.6% (82.2-99.9%, 95% CI) for samples with Ct values below 26 and a specificity of 100% (90-100%, 95% CI), thus being fit-for-purpose to diagnose patients with a high risk of viral transmission. These results show significant promise towards bringing routine point-of-care COVID-19 diagnostics to resource-limited settings.", "doi": "10.1039/d1lc00266j", "pmid": "34114589", "labels": {"Research Area: Diagnostics for virus": null, "Funder: KAW/SciLifeLab": null, "Funder: H2020": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-06T14:40:58.154Z", "modified": "2021-08-23T12:18:50.531Z"}, {"entity": "publication", "iuid": "03634cc797f44a70b47acd4b13e62fd1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/03634cc797f44a70b47acd4b13e62fd1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/03634cc797f44a70b47acd4b13e62fd1"}}, "title": "Correction to: Perceptions and effects of COVID-19 related information in Denmark and Sweden - a web-based survey about COVID-19 and social media.", "authors": [{"family": "Stjernsw\u00e4rd", "given": "Sigrid", "initials": "S", "orcid": "0000-0002-7152-9206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cda8ee3ae8564252aa6ffe2ab219ada8.json"}}, {"family": "Ivert", "given": "Anna-Karin", "initials": "AK", "orcid": "0000-0001-7749-9549", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fec7c74c7fa4df4849474c8c3a9e8a7.json"}}, {"family": "Glasdam", "given": "Stinne", "initials": "S", "orcid": "0000-0002-0893-3054", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c56787745d04e05ad85e53ce8df6061.json"}}], "type": "published erratum", "published": "2021-08-07", "journal": {"title": "Z Gesundh Wiss", "issn": "2198-1833", "pages": "1", "issn-l": null}, "abstract": "[This corrects the article DOI: 10.1007/s10389-021-01539-5.].", "doi": "10.1007/s10389-021-01642-7", "pmid": "34395176", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "1642"}, {"db": "pmc", "key": "PMC8346338"}], "notes": [], "created": "2021-08-17T06:43:31.753Z", "modified": "2021-08-17T06:43:31.856Z"}, {"entity": "publication", "iuid": "b444c703d7a148c4883271a70fd7e27f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b444c703d7a148c4883271a70fd7e27f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b444c703d7a148c4883271a70fd7e27f"}}, "title": "Voters' view of leaders during the Covid-19 crisis: Quantitative analysis of keyword descriptions provides strength and direction of evaluations.", "authors": [{"family": "Fred\u00e9n", "given": "Annika", "initials": "A", "orcid": "0000-0003-0820-8626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c0b021ac0de4dfdbc719292533683d6.json"}}, {"family": "Sikstr\u00f6m", "given": "Sverker", "initials": "S"}], "type": "journal article", "published": "2021-08-06", "journal": {"title": "Soc Sci Q", "issn": "0038-4941", "issn-l": null}, "abstract": "Previous research suggests that governments usually gain support during crises such as the Covid-19. However, these findings are based on rating scales that only allow us to measure the strength of this support. This article proposes a new measure of how voters evaluate Prime Ministers (PM) by asking for descriptive keywords that are analyzed by natural language processing.\n\nBy collecting a representative sample of citizens' own key words describing their PM in 15 countries in Europe during the outbreak of Covid-19, and analyzing these by latent semantic analysis and a multiple OLS regression, we could quantify the strength and direction of voters' view.\n\nThe strength analysis supported previous studies that describing the PM with positive words was strongly associated with vote intention. Furthermore, a change in the direction of the attitudes from \"good\" to \"honest\" was found. A new finding was that the pandemic was associated with an increase in polarization.\n\nThe keyword evaluation analysis provides opportunities of evaluating both strength and direction of voters' view of their PM, where we show new results related to increased polarization and shift in the direction of attitudes.", "doi": "10.1111/ssqu.13036", "pmid": "34548706", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "SSQU13036"}, {"db": "pmc", "key": "PMC8447460"}], "notes": [], "created": "2021-10-27T05:13:02.985Z", "modified": "2021-10-27T05:13:03.055Z"}, {"entity": "publication", "iuid": "76fa32053cc14e888d63db4413367003", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76fa32053cc14e888d63db4413367003.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76fa32053cc14e888d63db4413367003"}}, "title": "Secondary bacterial infections and antimicrobial resistance in COVID-19: comparative evaluation of pre-pandemic and pandemic-era, a retrospective single center study.", "authors": [{"family": "Karata\u015f", "given": "Mustafa", "initials": "M", "orcid": "0000-0002-2464-0593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe5e7d7c255f4b6394d7d0712c8af986.json"}}, {"family": "Ya\u015far-Duman", "given": "Melike", "initials": "M", "orcid": "0000-0001-8913-2314", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eee2e7153be4128987516582c5f82a5.json"}}, {"family": "T\u00fcnger", "given": "Alper", "initials": "A", "orcid": "0000-0002-1644-8833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2370d67703347be8fb05a1fc5c3fabe.json"}}, {"family": "\u00c7illi", "given": "Feriha", "initials": "F", "orcid": "0000-0003-3993-3396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0de7edbbcdda42f5a81352fb68d95bfe.json"}}, {"family": "Aydemir", "given": "\u015e\u00f6hret", "initials": "\u015e", "orcid": "0000-0001-8354-9100", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf04dbb9c5404c268f1a5b2497bbe24d.json"}}, {"family": "\u00d6zenci", "given": "Volkan", "initials": "V", "orcid": "0000-0002-8069-4027", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04a5e899bc05457496095b831df1391a.json"}}], "type": "journal article", "published": "2021-08-05", "journal": {"title": "Ann Clin Microbiol Antimicrob", "issn": "1476-0711", "volume": "20", "issue": "1", "pages": "51", "issn-l": null}, "abstract": "In this study, we aimed to evaluate the epidemiology and antimicrobial resistance (AMR) patterns of bacterial pathogens in COVID-19 patients and to compare the results with control groups from the pre-pandemic and pandemic era.\n\nMicrobiological database records of all the COVID-19 diagnosed patients in the Ege University Hospital between March 15, 2020, and June 15, 2020, evaluated retrospectively. Patients who acquired secondary bacterial infections (SBIs) and bacterial co-infections were analyzed. Etiology and AMR data of the bacterial infections were collected. Results were also compared to control groups from pre-pandemic and pandemic era data.\n\nIn total, 4859 positive culture results from 3532 patients were analyzed. Fifty-two (3.59%) patients had 78 SBIs and 38 (2.62%) patients had 45 bacterial co-infections among 1447 COVID-19 patients. 22/85 (25.88%) patients died who had bacterial infections. The respiratory culture-positive sample rate was 39.02% among all culture-positive samples in the COVID-19 group. There was a significant decrease in extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales (8.94%) compared to samples from the pre-pandemic (20.76%) and pandemic era (20.74%) (p = 0.001 for both comparisons). Interestingly, Acinetobacter baumannii was the main pathogen in the respiratory infections of COVID-19 patients (9.76%) and the rate was significantly higher than pre-pandemic (3.49%, p < 0.002) and pandemic era control groups (3.11%, p < 0.001).\n\nDue to the low frequency of SBIs reported during the ongoing pandemic, a more careful and targeted antimicrobial prescription should be taken. While patients with COVID-19 had lower levels of ESBL-producing Enterobacterales, the frequency of multidrug-resistant (MDR) A. baumannii is higher.", "doi": "10.1186/s12941-021-00454-7", "pmid": "34353332", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12941-021-00454-7"}, {"db": "pmc", "key": "PMC8340813"}], "notes": [], "created": "2021-08-11T14:42:06.234Z", "modified": "2021-08-11T14:42:06.390Z"}, {"entity": "publication", "iuid": "bf9ea7246bbc4f0bacd9505b617d039e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf9ea7246bbc4f0bacd9505b617d039e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf9ea7246bbc4f0bacd9505b617d039e"}}, "title": "Immunity to SARS-CoV-2 induced by infection or vaccination.", "authors": [{"family": "Castro Dopico", "given": "Xaquin", "initials": "X", "orcid": "0000-0002-9005-6774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/354c91b234fd4a039f85c13e7e4209c1.json"}}, {"family": "Ols", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-9784-7176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35eb7b8de6434661a729bab979f26c7d.json"}}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K", "orcid": "0000-0001-7679-9494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02d4d3d9ccc547f7ab18ba69493f6a34.json"}}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB", "orcid": "0000-0001-7255-9047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/891aa9ca3f604b7396a14d65a33c2187.json"}}], "type": "journal article", "published": "2021-08-05", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null}, "abstract": "Adaptive immune responses play critical roles in viral clearance and protection against re-infection, and SARS-CoV-2 is no exception. What is exceptional, is the rapid characterization of the immune response to the virus performed by researchers during the first 20 months of the pandemic. This has given us a more detailed understanding about SARS-CoV-2 than we have about many viruses that have been with us for a long time. Furthermore, effective COVID-19 vaccines were developed in record time, and their rollout worldwide is already making a significant difference, although major challenges remain in terms of equal access. The pandemic has engaged scientists and the public alike, and terms such as seroprevalence, neutralizing antibodies, antibody escape and vaccine certificates have become familiar to a broad community. Here, we review key findings concerning B cell and antibody (Ab) responses to SARS-CoV-2, focusing on non-severe cases and anti-spike (S) Ab responses in particular, the latter being central to protective immunity induced by infection or vaccination. The emergence of viral variants that have acquired mutations in S acutely highlights the need for continued characterization of both emerging variants and Ab responses against these during the evolving pathogen-immune system arms race.", "doi": "10.1111/joim.13372", "pmid": "34352148", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-08-06T08:55:00.572Z", "modified": "2021-08-06T08:55:00.672Z"}, {"entity": "publication", "iuid": "8918d87280614988a89a6fe124e69d32", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8918d87280614988a89a6fe124e69d32.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8918d87280614988a89a6fe124e69d32"}}, "title": "Higher rate of SARS-CoV-2 IgG seropositivity in hospital-based healthcare workers compared to elderly care staff in a Swedish low-prevalence region: a cross-sectional study.", "authors": [{"family": "Ocias", "given": "Lukas Frans", "initials": "LF"}, {"family": "Skogstam", "given": "Anna", "initials": "A"}, {"family": "Kjerstadius", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Lundin", "given": "Fredrik", "initials": "F"}, {"family": "Tevell", "given": "Staffan", "initials": "S", "orcid": "0000-0002-9213-9274", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12b1a3e80af94b3e8bbb3abbe247ecd0.json"}}], "type": "journal article", "published": "2021-08-05", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": "53", "issue": "12", "pages": "920-929"}, "abstract": "Previous seroprevalence studies have demonstrated higher anti-SARS-CoV-2 IgG seroprevalence in healthcare workers (HCWs) than in the background population during the first phase of the 2020 COVID-19 pandemic. These studies, however, focussed mainly on hospital employees.\r\n\r\nTo perform a cross-sectional study comparing the seroprevalence of hospital-based HCWs with those employed in elderly care (home care and nursing homes).\r\n\r\nEmployees (n = 4955) in the county of V\u00e4rmland, Sweden, were recruited between weeks 27 and 42 and tested for IgG antibodies against SARS-CoV-2. Serological results were combined with self-reported questionnaire data.\r\n\r\nIgG seroprevalence was 5.7% in the total group of HCWs, and was higher among those employed in hospital-based healthcare than among those working in elderly care (8.4% vs. 3.7%, p < .001). Being employed as an assistant nurse, working in a COVID-19 unit, and being exposed via co-workers or private acquaintances were all associated with IgG seropositivity.\r\n\r\nThe difference in seroprevalence between HCWs in the two settings suggests that not only the profession but also factors in the workplace environment may be of importance. As all studied exposures were associated with IgG seropositivity, and asymptomatic infection was detected in 7.5% of participants, preventing outbreaks among HCWs is challenging. Adequate use of personal protective equipment when working with patients regardless of COVID-19 status, source control in situations with co-workers in which distancing is not possible, and routines enabling symptomatic staff to isolate pending PCR results are required to prevent healthcare-associated outbreaks of COVID-19.", "doi": "10.1080/23744235.2021.1959949", "pmid": "34350813", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-06T08:55:23.783Z", "modified": "2021-11-18T13:25:45.879Z"}, {"entity": "publication", "iuid": "48eba88ae335446a9743f6fd56902d34", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/48eba88ae335446a9743f6fd56902d34.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/48eba88ae335446a9743f6fd56902d34"}}, "title": "Role of potential COVID-19 immune system associated genes and the potential pathways linkage with type-2 diabetes.", "authors": [{"family": "Helmi", "given": "Nawal", "initials": "N"}, {"family": "Alammari", "given": "Dalia", "initials": "D"}, {"family": "Mobashir", "given": "Mohammad", "initials": "M"}], "type": "journal article", "published": "2021-08-04", "journal": {"title": "Comb Chem High Throughput Screen", "issn": "1875-5402", "issn-l": null}, "abstract": "Coronavirus is an enveloped positive-sense RNA virus and is characterized by club-like spikes projecting from its surface which is commonly associated with acute respiratory infections in humans but its ability to infect multiple host species and multiple diseases brings it to a complex pathogen group. The frequent interactions of wild animals with humans it is more prevalent a common source of such infections and SARS-CoV and MERS-CoV are the zoonotic pathogens among the leading cause of severe respiratory diseases in humans.\n\nThe major purpose of this study was to study the gene expression profiling for those human samples which are infected with coronavirus or uninfected and compare the differential expression patterns and its functional impact.\n\nFor this purpose, the previously studied samples have been collected from public database and the study had been performed and it includes gene expression analysis, pathway analysis, and the network-level understanding. The analysis presents the data for the differentially expressed genes, enriched pathways and the networks for the potential genes and gene sets. In terms of gene expression and the linkage of COVID-19 with type-2 diabetes.\n\nWe observe that there are a large number of genes which show altered gene expression pattern than the normal for coronavirus infection while in terms of pathways it appears that there are few sets of functions which are affected due to altered gene expression and they infer to infection, inflammation, and the immune system.\n\nBased on our study, we conclude that the potential genes which are affected due to infection are NFKBIA, MYC, FOXO3, BIRC3, ICAM1, IL8, CXCL1/2/5, GADD45A, RELB, SGK1, AREG, BBC3, DDIT3/4, EGR1, MTHFD2, and SESN2 and the functional changes are mainly associated with these pathways TNF, cytokine, NF-kB, TLR, TCR, BCR, Foxo, and TGF signaling pathways are among them and there are additional pathways such as hippo signaling, apoptosis, estrogen signaling, regulating pluropotency of stem cells, ErbB, Wnt, p53, cAMP, MAPK, PI3K-AKT, oxidative phosphorylation, protein processing in endoplasmic reticulum, prolactin signaling, adipocytokine, neurotrophine signaling, and longevity regulating pathways. SMARCD3, PARL, GLIPR1, STAT2, PMAIP1, GP1BA, and TOX genes and PI3K-Akt, focal adhesion, Foxo, phagosome, adrenergic, osteoclast differentiation, platelet activation, insulin, cytokine-cytokine interaction, apoptosis, ECM, JAK-STAT, and oxytocine signaling appear as the linkage between COVID-19 and Type-2 diabetes.", "doi": "10.2174/1386207324666210804124416", "pmid": "34348612", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "CCHTS-EPUB-117038"}], "notes": [], "created": "2021-08-06T09:42:09.565Z", "modified": "2021-08-06T09:42:27.505Z"}, {"entity": "publication", "iuid": "5f9fb8c55117495fae2f3a7f43e2ea34", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f9fb8c55117495fae2f3a7f43e2ea34.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f9fb8c55117495fae2f3a7f43e2ea34"}}, "title": "Risk Perception and Protective Behavior in the Context of COVID-19: a Qualitative Exploration.", "authors": [{"family": "Siddiqui", "given": "Salma", "initials": "S"}, {"family": "Qamar", "given": "Azher Hameed", "initials": "AH", "orcid": "0000-0002-6137-6533", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27dff98f20e04eb3896dfab7e775c56f.json"}}], "type": "journal article", "published": "2021-08-04", "journal": {"title": "Asian Bioeth Rev", "issn": "1793-9453", "pages": "1-20", "issn-l": null}, "abstract": "As a result of the devastating health effects of the COVID-19 outbreak, the lockdown has been considered a safety measure in many countries. In Pakistan, the first case of COVID-19 was reported in February 2020. The purpose of this qualitative study was to investigate people's risk perception and protective behavior during the lockdown. Twenty-two (22) participants from eight big cities across Pakistan were interviewed. A six-step reflective thematic analysis was used for data analysis. The study focused on risk perception and protective behaviors. Our main analytical goal was to understand how risk perception shapes human behavior in the context of lockdown, pandemic-related information flow, and corresponding meaning-making. The study revealed that people influenced by information and advice campaigns form a perception of risk that has shaped their protective behavior. They used familiar means of coping with distress, including the search for strength through religious belief practices and following the precautions recommended by health professionals through the media.", "doi": "10.1007/s41649-021-00181-3", "pmid": "34367345", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "181"}, {"db": "pmc", "key": "PMC8335444"}], "notes": [], "created": "2021-08-11T14:34:57.786Z", "modified": "2021-08-11T14:36:16.611Z"}, {"entity": "publication", "iuid": "8050b697856f485ab35747b02497d14a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8050b697856f485ab35747b02497d14a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8050b697856f485ab35747b02497d14a"}}, "title": "Insomnia, anxiety, and depression during the COVID-19 pandemic: an international collaborative study.", "authors": [{"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Chung", "given": "Frances", "initials": "F"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "Penzel", "given": "Thomas", "initials": "T"}, {"family": "Ivers", "given": "Hans", "initials": "H"}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK"}, {"family": "Chan", "given": "Ngan Yin", "initials": "NY"}, {"family": "Merikanto", "given": "Ilona", "initials": "I"}, {"family": "Mota-Rolim", "given": "Sergio", "initials": "S"}, {"family": "Mac\u00eado", "given": "Tain\u00e1", "initials": "T"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L"}, {"family": "L\u00e9ger", "given": "Damien", "initials": "D"}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y"}, {"family": "Plazzi", "given": "Giuseppe", "initials": "G"}, {"family": "Nadorff", "given": "Michael R", "initials": "MR"}, {"family": "Bolstad", "given": "Courtney J", "initials": "CJ"}, {"family": "Sieminski", "given": "Mariusz", "initials": "M"}, {"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J"}, {"family": "Inoue", "given": "Yuchi", "initials": "Y"}, {"family": "Han", "given": "Fang", "initials": "F"}, {"family": "Espie", "given": "Colin A", "initials": "CA"}], "type": "journal article", "published": "2021-08-04", "journal": {"title": "Sleep Med", "issn": "1878-5506", "volume": "87", "pages": "38-45", "issn-l": null}, "abstract": "The COVID-19 pandemic has produced unprecedented changes in social, work, and leisure activities, which all have had major impact on sleep and psychological well-being. This study documented the prevalence of clinical cases of insomnia, anxiety, and depression and selected risk factors (COVID-19, confinement, financial burden, social isolation) during the first wave of the pandemic in 13 countries throughout the world.\n\nInternational, multi-center, harmonized survey of 22 330 adults (mean age = 41.9 years old, range 18-95; 65.6% women) from the general population in 13 countries and four continents. Participants were invited to complete a standardized web-based survey about sleep and psychological symptoms during the first wave of the COVID-19 pandemic from May to August 2020.\n\nClinical insomnia symptoms were reported by 36.7% (95% CI, 36.0-37.4) of respondents and 17.4% (95% CI, 16.9-17.9) met criteria for a probable insomnia disorder. There were 25.6% (95% CI, 25.0-26.2) with probable anxiety and 23.1% (95% CI, 22.5-23.6) with probable depression. Rates of insomnia symptoms (>40%) and insomnia disorder (>25%) were significantly higher in women, younger age groups, and in residents of Brazil, Canada, Norway, Poland, USA, and United Kingdom compared to residents from Asian countries (China and Japan, 8% for disorder and 22%-25% for symptoms) (all Ps < 0.01). Proportions of insomnia cases were significantly higher among participants who completed the survey earlier in the first wave of the pandemic relative to those who completed it later. Risks of insomnia were higher among participants who reported having had COVID-19, who reported greater financial burden, were in confinement for a period of four to five weeks, and living alone or with more than five people in same household. These associations remained significant after controlling for age, sex, and psychological symptoms.\n\nInsomnia, anxiety, and depression were very prevalent during the first wave of the COVID-19 pandemic. Public health prevention programs are needed to prevent chronicity and reduce long-term adverse outcomes associated with chronic insomnia and mental health problems.", "doi": "10.1016/j.sleep.2021.07.035", "pmid": "34508986", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1389-9457(21)00419-6"}], "notes": [], "created": "2021-09-13T06:31:15.919Z", "modified": "2021-09-13T06:31:15.942Z"}, {"entity": "publication", "iuid": "1180428124864f828411a81b51033272", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1180428124864f828411a81b51033272.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1180428124864f828411a81b51033272"}}, "title": "Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease.", "authors": [{"family": "Ricke-Hoch", "given": "Melanie", "initials": "M", "orcid": "0000-0001-5479-2275", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cd10380b93048dbae752276651ca2d3.json"}}, {"family": "Stelling", "given": "Elisabeth", "initials": "E"}, {"family": "Lasswitz", "given": "Lisa", "initials": "L"}, {"family": "Gunesch", "given": "Antonia P", "initials": "AP"}, {"family": "Kasten", "given": "Martina", "initials": "M"}, {"family": "Zapatero-Belinch\u00f3n", "given": "Francisco J", "initials": "FJ"}, {"family": "Brogden", "given": "Graham", "initials": "G"}, {"family": "Gerold", "given": "Gisa", "initials": "G", "orcid": "0000-0002-1326-5038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39af3df98cf14f96baa155798617841b.json"}}, {"family": "Pietschmann", "given": "Thomas", "initials": "T"}, {"family": "Montiel", "given": "Virginie", "initials": "V"}, {"family": "Balligand", "given": "Jean-Luc", "initials": "JL"}, {"family": "Facciotti", "given": "Federica", "initials": "F"}, {"family": "Hirsch", "given": "Emilio", "initials": "E"}, {"family": "Gausepohl", "given": "Thomas", "initials": "T", "orcid": "0000-0003-1669-5911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd75a34037c14a1da4a85449ece2d242.json"}}, {"family": "Elbahesh", "given": "Husni", "initials": "H", "orcid": "0000-0003-1243-0967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822945b93dea44058ffd0881204ff742.json"}}, {"family": "Rimmelzwaan", "given": "Guus F", "initials": "GF"}, {"family": "H\u00f6fer", "given": "Anne", "initials": "A"}, {"family": "K\u00fchnel", "given": "Mark P", "initials": "MP"}, {"family": "Jonigk", "given": "Danny", "initials": "D"}, {"family": "Eigendorf", "given": "Julian", "initials": "J"}, {"family": "Tegtbur", "given": "Uwe", "initials": "U"}, {"family": "Mink", "given": "Lena", "initials": "L"}, {"family": "Scherr", "given": "Michaela", "initials": "M"}, {"family": "Illig", "given": "Thomas", "initials": "T"}, {"family": "Schambach", "given": "Axel", "initials": "A"}, {"family": "Pfeffer", "given": "Tobias J", "initials": "TJ"}, {"family": "Hilfiker", "given": "Andres", "initials": "A"}, {"family": "Haverich", "given": "Axel", "initials": "A"}, {"family": "Hilfiker-Kleiner", "given": "Denise", "initials": "D"}], "type": "journal article", "published": "2021-08-04", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "8", "pages": "e0255335", "issn-l": "1932-6203"}, "abstract": "The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds that risk-factors for severe COVID-19 disease courses, i.e. male sex, older age and sedentary life style are associated with higher prostaglandin E2 (PGE2) serum levels in blood samples from unaffected subjects. In COVID-19 patients, PGE2 blood levels are markedly elevated and correlate positively with disease severity. SARS-CoV-2 induces PGE2 generation and secretion in infected lung epithelial cells by upregulating cyclo-oxygenase (COX)-2 and reducing the PG-degrading enzyme 15-hydroxyprostaglandin-dehydrogenase. Also living human precision cut lung slices (PCLS) infected with SARS-CoV-2 display upregulated COX-2. Regular exercise in aged individuals lowers PGE2 serum levels, which leads to increased Paired-Box-Protein-Pax-5 (PAX5) expression, a master regulator of B-cell survival, proliferation and differentiation also towards long lived memory B-cells, in human pre-B-cell lines. Moreover, PGE2 levels in serum of COVID-19 patients lowers the expression of PAX5 in human pre-B-cell lines. The PGE2 inhibitor Taxifolin reduces SARS-CoV-2-induced PGE2 production. In conclusion, SARS-CoV-2, male sex, old age, and sedentary life style increase PGE2 levels, which may reduce the early anti-viral defense as well as the development of immunity promoting severe disease courses and multiple infections. Regular exercise and Taxifolin treatment may reduce these risks and prevent severe disease courses.", "doi": "10.1371/journal.pone.0255335", "pmid": "34347801", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-08028"}], "notes": [], "created": "2021-08-06T09:44:33.183Z", "modified": "2021-08-06T09:45:32.764Z"}, {"entity": "publication", "iuid": "b172f9cf78d446e6ac4011711b51c1cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b172f9cf78d446e6ac4011711b51c1cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b172f9cf78d446e6ac4011711b51c1cb"}}, "title": "A quantitative analysis of extension and distribution of lung injury in COVID-19: a prospective study based on chest computed tomography.", "authors": [{"family": "Pellegrini", "given": "Mariangela", "initials": "M"}, {"family": "Larina", "given": "Aleksandra", "initials": "A"}, {"family": "Mourtos", "given": "Evangelos", "initials": "E"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Segelsj\u00f6", "given": "Monica", "initials": "M"}, {"family": "Hansen", "given": "Tomas", "initials": "T"}, {"family": "Perchiazzi", "given": "Gaetano", "initials": "G", "orcid": "0000-0001-6834-6399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ef9ffc76bfe47c5afff104e9aaef020.json"}}], "type": "journal article", "published": "2021-08-04", "journal": {"title": "Crit Care", "issn": "1466-609X", "issn-l": "1364-8535", "volume": "25", "issue": "1", "pages": "276"}, "abstract": "Typical features differentiate COVID-19-associated lung injury from acute respiratory distress syndrome. The clinical role of chest computed tomography (CT) in describing the progression of COVID-19-associated lung injury remains to be clarified. We investigated in COVID-19 patients the regional distribution of lung injury and the influence of clinical and laboratory features on its progression.\n\nThis was a prospective study. For each CT, twenty images, evenly spaced along the cranio-caudal axis, were selected. For regional analysis, each CT image was divided into three concentric subpleural regions of interest and four quadrants. Hyper-, normally, hypo- and non-inflated lung compartments were defined. Nonparametric tests were used for hypothesis testing (\u03b1 = 0.05). Spearman correlation test was used to detect correlations between lung compartments and clinical features.\n\nTwenty-three out of 111 recruited patients were eligible for further analysis. Five hundred-sixty CT images were analyzed. Lung injury, composed by hypo- and non-inflated areas, was significantly more represented in subpleural than in core lung regions. A secondary, centripetal spread of lung injury was associated with exposure to mechanical ventilation (p < 0.04), longer spontaneous breathing (more than 14 days, p < 0.05) and non-protective tidal volume (p < 0.04). Positive fluid balance (p < 0.01), high plasma D-dimers (p < 0.01) and ferritin (p < 0.04) were associated with increased lung injury.\n\nIn a cohort of COVID-19 patients with severe respiratory failure, a predominant subpleural distribution of lung injury is observed. Prolonged spontaneous breathing and high tidal volumes, both causes of patient self-induced lung injury, are associated to an extensive involvement of more central regions. Positive fluid balance, inflammation and thrombosis are associated with lung injury. Trial registration Study registered a priori the 20th of March, 2020. Clinical Trials ID NCT04316884.", "doi": "10.1186/s13054-021-03685-4", "pmid": "34348797", "labels": {"Funder: VR": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC8334337"}, {"db": "pii", "key": "10.1186/s13054-021-03685-4"}, {"db": "ClinicalTrials.gov", "key": "NCT04316884"}], "notes": [], "created": "2021-08-06T09:37:31.364Z", "modified": "2023-06-19T15:20:10.287Z"}, {"entity": "publication", "iuid": "f663618c9d864a089fdda6d5102066c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f663618c9d864a089fdda6d5102066c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f663618c9d864a089fdda6d5102066c9"}}, "title": "Update on: high but slightly declining COVID-19 vaccine acceptance and reasons for vaccine acceptance, Finland April to December 2020.", "authors": [{"family": "Hammer", "given": "Charlotte C", "initials": "CC", "orcid": "0000-0002-8288-0288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d188cd00689408ba9d6e336ed590f00.json"}}, {"family": "Cristea", "given": "Veronica", "initials": "V"}, {"family": "Dub", "given": "Timothee", "initials": "T", "orcid": "0000-0002-1819-518X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/034bb5fac60841c180b6a12101d5f4f0.json"}}, {"family": "Sivel\u00e4", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2021-08-03", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "issn-l": null, "volume": "149", "issue": null, "pages": "e187"}, "abstract": "We update our previous insights into COVID-19 vaccine acceptance and hesitancy in Finland. Vaccine acceptance increased from 64% (November/December 2020) to 74% (April 2021). However, there was a group of participants that were preferring to wait to get vaccinated ranging from 6% of over-64-years-olds to 29% of under-30-years-olds. The previously identified enablers convenience (below-50-years-olds), worry about severe disease and protection for oneself (above-50-years-olds) were no longer significantly associated with increased vaccine acceptance. Understanding barriers and enablers behind vaccine acceptance is decisive in ensuring a successful implementation of COVID-19 vaccination programs, which will be key to ending the pandemic.", "doi": "10.1017/S0950268821001680", "pmid": "34340722", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0950268821001680"}, {"db": "pmc", "key": "PMC8367874"}], "notes": [], "created": "2021-08-04T10:09:49.065Z", "modified": "2021-11-18T13:12:31.967Z"}, {"entity": "publication", "iuid": "44faeeb61bf343ae8acc034596145407", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44faeeb61bf343ae8acc034596145407.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44faeeb61bf343ae8acc034596145407"}}, "title": "Publisher Correction: Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice.", "authors": [{"family": "De Gasparo", "given": "Raoul", "initials": "R"}, {"family": "Pedotti", "given": "Mattia", "initials": "M"}, {"family": "Simonelli", "given": "Luca", "initials": "L"}, {"family": "Nickl", "given": "Petr", "initials": "P", "orcid": "0000-0002-4289-0502", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd09e87cae524e40922a94720a978674.json"}}, {"family": "Muecksch", "given": "Frauke", "initials": "F", "orcid": "0000-0002-0132-5101", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94b175929ad14fec921e737bb3dceda7.json"}}, {"family": "Cassaniti", "given": "Irene", "initials": "I"}, {"family": "Percivalle", "given": "Elena", "initials": "E"}, {"family": "Lorenzi", "given": "Julio C C", "initials": "JCC"}, {"family": "Mazzola", "given": "Federica", "initials": "F"}, {"family": "Magr\u00ec", "given": "Davide", "initials": "D", "orcid": "0000-0003-3790-5332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15cedaba7cb3438fad6c71e2a015921e.json"}}, {"family": "Michalcikova", "given": "Tereza", "initials": "T"}, {"family": "Haviernik", "given": "Jan", "initials": "J"}, {"family": "Honig", "given": "Vaclav", "initials": "V", "orcid": "0000-0003-0469-4604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65499eafa5a24320b87d2534f4dcf99a.json"}}, {"family": "Mrazkova", "given": "Blanka", "initials": "B"}, {"family": "Polakova", "given": "Natalie", "initials": "N"}, {"family": "Fortova", "given": "Andrea", "initials": "A"}, {"family": "Tureckova", "given": "Jolana", "initials": "J"}, {"family": "Iatsiuk", "given": "Veronika", "initials": "V"}, {"family": "Di Girolamo", "given": "Salvatore", "initials": "S"}, {"family": "Palus", "given": "Martin", "initials": "M"}, {"family": "Zudova", "given": "Dagmar", "initials": "D"}, {"family": "Bednar", "given": "Petr", "initials": "P"}, {"family": "Bukova", "given": "Ivana", "initials": "I"}, {"family": "Bianchini", "given": "Filippo", "initials": "F"}, {"family": "Mehn", "given": "Dora", "initials": "D"}, {"family": "Nencka", "given": "Radim", "initials": "R"}, {"family": "Strakova", "given": "Petra", "initials": "P"}, {"family": "Pavlis", "given": "Oto", "initials": "O"}, {"family": "Rozman", "given": "Jan", "initials": "J", "orcid": "0000-0002-8035-8904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69dca82b58b8449c8af3e096813d6003.json"}}, {"family": "Gioria", "given": "Sabrina", "initials": "S"}, {"family": "Sammartino", "given": "Jos\u00e8 Camilla", "initials": "JC"}, {"family": "Giardina", "given": "Federica", "initials": "F"}, {"family": "Gaiarsa", "given": "Stefano", "initials": "S"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q", "orcid": "0000-0003-1990-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94a32366862b470eba3a15521b9be290.json"}}, {"family": "Barnes", "given": "Christopher O", "initials": "CO"}, {"family": "Bjorkman", "given": "Pamela J", "initials": "PJ", "orcid": "0000-0002-2277-3990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65549e18865046ac99cfee9f969c2759.json"}}, {"family": "Calzolai", "given": "Luigi", "initials": "L", "orcid": "0000-0002-8474-7974", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e3a67661994a48e28a8279fb27346285.json"}}, {"family": "Piralla", "given": "Antonio", "initials": "A", "orcid": "0000-0002-6062-2579", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af56fb1bc11f43d9861faa71c5b50043.json"}}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Nussenzweig", "given": "Michel C", "initials": "MC"}, {"family": "Bieniasz", "given": "Paul D", "initials": "PD", "orcid": "0000-0002-2368-3719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72f7075120214d4091202cd80ffbe506.json"}}, {"family": "Hatziioannou", "given": "Theodora", "initials": "T"}, {"family": "Prochazka", "given": "Jan", "initials": "J"}, {"family": "Sedlacek", "given": "Radislav", "initials": "R", "orcid": "0000-0002-3352-392X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a1594084f604610a995def1f7a6bdb2.json"}}, {"family": "Robbiani", "given": "Davide F", "initials": "DF", "orcid": "0000-0001-7379-3484", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/941e237779f74a568228c6fe1ee8800c.json"}}, {"family": "Ruzek", "given": "Daniel", "initials": "D", "orcid": "0000-0003-4655-2380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f49c5724719433ea99ebf38a4ff4a58.json"}}, {"family": "Varani", "given": "Luca", "initials": "L", "orcid": "0000-0002-0963-0987", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6c4a4cecfc04659b3b8df2b49430ba6.json"}}], "type": "published erratum", "published": "2021-08-03", "journal": {"title": "Nature", "issn": "1476-4687", "issn-l": "0028-0836"}, "abstract": null, "doi": "10.1038/s41586-021-03719-5", "pmid": "34345019", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41586-021-03719-5"}], "notes": [], "created": "2021-08-06T09:46:27.837Z", "modified": "2021-08-06T09:46:31.466Z"}, {"entity": "publication", "iuid": "49c5fcdae47f44838b85c4eafba0ec1c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49c5fcdae47f44838b85c4eafba0ec1c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49c5fcdae47f44838b85c4eafba0ec1c"}}, "title": "Prevalence and determinants of serum antibodies to SARS-CoV-2 in the general population of the Gardena valley.", "authors": [{"family": "Melotti", "given": "Roberto", "initials": "R", "orcid": "0000-0003-4115-317X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9aadc5f020e74449a6ad0f6b87c55ec1.json"}}, {"family": "Scaggiante", "given": "Federica", "initials": "F"}, {"family": "Falciani", "given": "Michela", "initials": "M"}, {"family": "Weichenberger", "given": "Christian X", "initials": "CX"}, {"family": "Foco", "given": "Luisa", "initials": "L"}, {"family": "Lombardo", "given": "Stefano", "initials": "S"}, {"family": "De Grandi", "given": "Alessandro", "initials": "A"}, {"family": "von Laer", "given": "Dorothee", "initials": "D"}, {"family": "Mahlknecht", "given": "Angelika", "initials": "A"}, {"family": "Pramstaller", "given": "Peter P", "initials": "PP"}, {"family": "Pagani", "given": "Elisabetta", "initials": "E", "orcid": "0000-0002-4008-6756", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1161d621cf434cb8a7a245e40f2fc90f.json"}}, {"family": "Meier", "given": "Horand", "initials": "H"}, {"family": "Gaertner", "given": "Timon", "initials": "T"}, {"family": "Troi", "given": "Christina", "initials": "C"}, {"family": "Mascalzoni", "given": "Deborah", "initials": "D"}, {"family": "Pattaro", "given": "Cristian", "initials": "C"}, {"family": "Mian", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2021-08-03", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": "149", "pages": "e194", "issn-l": null}, "abstract": "Estimating the spread of SARS-CoV-2 infection in communities is critical. We surveyed 2244 stratified random sample community members of the Gardena valley, a winter touristic area, amidst the first expansion phase of the COVID-19 pandemic in Europe. We measured agreement between Diasorin and Abbott serum bioassay outputs and the Abbott optimal discriminant threshold of serum neutralisation titres with recursive receiver operating characteristic curve. We analytically adjusted serum antibody tests for unbiased seroprevalence estimate and analysed the determinants of infection with non-response weighted multiple logistic regression. SARS-CoV-2 seroprevalence was 26.9% (95% CI 25.2-28.6) by June 2020. The bioassays had a modest agreement with each other. At a lower threshold than the manufacturer's recommended level, the Abbott assay reflected greater discrimination of serum neutralisation capacity. Seropositivity was associated with place and economic activity, not with sex or age. Symptoms like fever and weakness were age-dependent. SARS-CoV-2 mitigation strategies should account for context in high prevalence areas.", "doi": "10.1017/S0950268821001886", "pmid": "34645534", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0950268821001886"}, {"db": "pmc", "key": "PMC8387688"}], "notes": [], "created": "2021-10-21T05:07:20.223Z", "modified": "2021-10-21T05:07:20.314Z"}, {"entity": "publication", "iuid": "5b8ec62501cf41da8f6c8fdc9837a030", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5b8ec62501cf41da8f6c8fdc9837a030.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5b8ec62501cf41da8f6c8fdc9837a030"}}, "title": "Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients.", "authors": [{"family": "Huckriede", "given": "Joram", "initials": "J"}, {"family": "Anderberg", "given": "Sara B\u00fclow", "initials": "SB"}, {"family": "Morales", "given": "Albert", "initials": "A"}, {"family": "de Vries", "given": "Femke", "initials": "F"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Bergqvist", "given": "Anders", "initials": "A"}, {"family": "Ortiz-P\u00e9rez", "given": "Jos\u00e9 T", "initials": "JT"}, {"family": "Sels", "given": "Jan Willem", "initials": "JW"}, {"family": "Wichapong", "given": "Kanin", "initials": "K"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "van de Poll", "given": "Marcel", "initials": "M"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Luther", "given": "Tomas", "initials": "T"}, {"family": "Reutelingsperger", "given": "Chris", "initials": "C"}, {"family": "de Frutos", "given": "Pablo Garcia", "initials": "PG"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Nicolaes", "given": "Gerry A F", "initials": "GAF"}], "type": "journal article", "published": "2021-08-03", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "15701"}, "abstract": "Coronavirus disease 19 (COVID-19) presents with disease severities of varying degree. In its most severe form, infection may lead to respiratory failure and multi-organ dysfunction. Here we study the levels and evolution of the damage associated molecular patterns (DAMPS) cell free DNA (cfDNA), extracellular histone H3 (H3) and neutrophil elastase (NE), and the immune modulators GAS6 and AXL in relation to clinical parameters, ICU scoring systems and mortality in patients (n = 100) with severe COVID-19. cfDNA, H3, NE, GAS6 and AXL were increased in COVID-19 patients compared to controls. These measures associated with occurrence of clinical events and intensive care unit acquired weakness (ICUAW). cfDNA and GAS6 decreased in time in patients surviving to 30 days post ICU admission. A decrease of 27.2 ng/mL cfDNA during ICU stay associated with patient survival, whereas levels of GAS6 decreasing more than 4.0 ng/mL associated with survival. The presence of H3 in plasma was a common feature of COVID-19 patients, detected in 38% of the patients at ICU admission. NETosis markers cfDNA, H3 and NE correlated well with parameters of tissue damage and neutrophil counts. Furthermore, cfDNA correlated with lowest p/f ratio and a lowering in cfDNA was observed in patients with ventilator-free days.", "doi": "10.1038/s41598-021-95209-x", "pmid": "34344929", "labels": {"Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-95209-x"}], "notes": [], "created": "2021-01-04T09:26:11.519Z", "modified": "2021-08-06T09:49:20.947Z"}, {"entity": "publication", "iuid": "91448b51a4264a738436edb06b9f2b23", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/91448b51a4264a738436edb06b9f2b23.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/91448b51a4264a738436edb06b9f2b23"}}, "title": "Persisting Salivary IgG Against SARS-CoV-2 at 9 Months After Mild COVID-19: A Complementary Approach to Population Surveys.", "authors": [{"family": "Alkharaan", "given": "Hassan", "initials": "H"}, {"family": "Bayati", "given": "Shaghayegh", "initials": "S"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Olsson", "given": "Annika", "initials": "A"}, {"family": "Lindahl", "given": "Karin", "initials": "K"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "Tsilingaridis", "given": "Georgios", "initials": "G"}, {"family": "De Palma", "given": "Patricia", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M", "orcid": "0000-0002-3793-4064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4bc179656eb442f9ac9dc72c8c6841d.json"}}], "type": "journal article", "published": "2021-08-02", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899", "volume": "224", "issue": "3", "pages": "407-414"}, "abstract": "Declining humoral immunity in coronavirus disease 2019 (COVID-19) patients and possible reinfection have raised concern. Mucosal immunity, particularly salivary antibodies, may be short lived although long-term studies are lacking.\r\n\r\nUsing a multiplex bead-based array platform, we investigated antibodies specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins in 256 saliva samples from convalescent patients 1-9 months after symptomatic COVID-19 (n = 74, cohort 1), undiagnosed individuals with self-reported questionnaires (n = 147, cohort 2), and individuals sampled prepandemic (n = 35, cohort 3).\r\n\r\nSalivary IgG antibody responses in cohort 1 (mainly mild COVID-19) were detectable up to 9 months postrecovery, with high correlations between spike and nucleocapsid specificity. At 9 months, IgG remained in blood and saliva in most patients. Salivary IgA was rarely detected at this time point. In cohort 2, salivary IgG and IgA responses were significantly associated with recent history of COVID-19-like symptoms. Salivary IgG tolerated temperature and detergent pretreatments.\r\n\r\nUnlike SARS-CoV-2 salivary IgA that appeared short lived, specific saliva IgG appeared stable even after mild COVID-19, as for blood serology. This noninvasive saliva-based SARS-CoV-2 antibody test with home self-collection may be a complementary alternative to conventional blood serology.", "doi": "10.1093/infdis/jiab256", "pmid": "33978762", "labels": {"Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: High-throughput and high-content serology": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "6274637"}, {"db": "pmc", "key": "PMC8244549"}], "notes": [], "created": "2021-05-17T18:21:49.460Z", "modified": "2021-11-18T15:58:51.138Z"}, {"entity": "publication", "iuid": "dfb5199537e741fdbd4383c7cea19f7c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dfb5199537e741fdbd4383c7cea19f7c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dfb5199537e741fdbd4383c7cea19f7c"}}, "title": "Correlates of intended COVID-19 vaccine acceptance across time and countries: results from a series of cross-sectional surveys.", "authors": [{"family": "Kerr", "given": "John R", "initials": "JR", "orcid": "0000-0002-6606-5507", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7189181d83744a68a99673f7d3a1c28c.json"}}, {"family": "Schneider", "given": "Claudia R", "initials": "CR", "orcid": "0000-0002-6612-5186", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6bbf77e665d4610b7bfe907bc934e9f.json"}}, {"family": "Recchia", "given": "Gabriel", "initials": "G", "orcid": "0000-0002-0210-8635", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e373f0f611e14509b26b643e736506ce.json"}}, {"family": "Dryhurst", "given": "Sarah", "initials": "S", "orcid": "0000-0002-7772-8492", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27179dd2c377475eb5aff23c270ebae4.json"}}, {"family": "Sahlin", "given": "Ullrika", "initials": "U", "orcid": "0000-0002-2932-6253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5af5b2eef6ab49dc8e91d3b41a973242.json"}}, {"family": "Dufouil", "given": "Carole", "initials": "C", "orcid": "0000-0003-2442-4476", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd796b2a505c4549a60d215286f851e0.json"}}, {"family": "Arwidson", "given": "Pierre", "initials": "P"}, {"family": "Freeman", "given": "Alexandra Lj", "initials": "AL", "orcid": "0000-0002-4115-161X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/746c0638712541e78b89fca05787da4e.json"}}, {"family": "van der Linden", "given": "Sander", "initials": "S", "orcid": "0000-0002-0269-1744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e54f2d24c11437d8b032ffab9b6909e.json"}}], "type": "journal article", "published": "2021-08-02", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "8", "pages": "e048025"}, "abstract": "Describe demographical, social and psychological correlates of willingness to receive a COVID-19 vaccine.\r\n\r\nSeries of online surveys undertaken between March and October 2020.\r\n\r\nA total of 25 separate national samples (matched to country population by age and sex) in 12 different countries were recruited through online panel providers (n=25 334).\r\n\r\nReported willingness to receive a COVID-19 vaccination.\r\n\r\nReported willingness to receive a vaccine varied widely across samples, ranging from 63% to 88%. Multivariate logistic regression analyses reveal sex (female OR=0.59, 95% CI 0.55 to 0.64), trust in medical and scientific experts (OR=1.28, 95% CI 1.22 to 1.34) and worry about the COVID-19 virus (OR=1.47, 95% CI 1.41 to 1.53) as the strongest correlates of stated vaccine acceptance considering pooled data and the most consistent correlates across countries. In a subset of UK samples, we show that these effects are robust after controlling for attitudes towards vaccination in general.\r\n\r\nOur results indicate that the burden of trust largely rests on the shoulders of the scientific and medical community, with implications for how future COVID-19 vaccination information should be communicated to maximise uptake.", "doi": "10.1136/bmjopen-2020-048025", "pmid": "34341047", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-048025"}, {"db": "URL", "key": "https://osf.io/p3fau/", "description": "Vaccine data"}, {"db": "URL", "key": "https://osf.io/wdjqx/", "description": "First case and first death per country"}], "notes": [], "created": "2021-08-04T10:09:21.889Z", "modified": "2021-11-19T11:24:29.832Z"}, {"entity": "publication", "iuid": "223875a4ae8849d1acaa4e0e4e94cafb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/223875a4ae8849d1acaa4e0e4e94cafb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/223875a4ae8849d1acaa4e0e4e94cafb"}}, "title": "Clinical characteristics and factors associated with COVID-19-related death and morbidity among hospitalized patients with cancer: a Swedish cohort study.", "authors": [{"family": "Ullgren", "given": "Helena", "initials": "H", "orcid": "0000-0001-5747-853X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8778c04e9c5a45a480e31c662d6b3459.json"}}, {"family": "Camuto", "given": "Angela", "initials": "A"}, {"family": "Rosas", "given": "Sumy", "initials": "S"}, {"family": "Pahnke", "given": "Simon", "initials": "S", "orcid": "0000-0002-3541-2027", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f7056035dab4a0080d35b40977463a8.json"}}, {"family": "Ginman", "given": "Beatrice", "initials": "B"}, {"family": "Enblad", "given": "Gunilla", "initials": "G", "orcid": "0000-0002-0594-724X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06a5b2ff78ac42c79e867240bbc11038.json"}}, {"family": "Glimelius", "given": "Ingrid", "initials": "I"}, {"family": "Fransson", "given": "Per", "initials": "P"}, {"family": "Friesland", "given": "Signe", "initials": "S"}, {"family": "Liu", "given": "Lisa", "initials": "L"}], "type": "journal article", "published": "2021-08-02", "journal": {"title": "Acta Oncol", "issn": "1651-226X", "pages": "1-7", "issn-l": null}, "abstract": "Cancer patients are considered to have a higher risk of dying and developing severe Coronavirus Disease 2019 (COVID-19). To date, there are few studies including co-morbidities and sociodemographic factors when investigating the outcome of COVID-19 in a cohort of cancer patients. In this study, we analyzed cancer patients that have been hospitalized due to COVID-19 during the first wave of the pandemic in Sweden to investigate the impact of COVID-19 on mortality and morbidity.\n\nWe retrospectively collected data on all patients with cancer that were hospitalized due to COVID-19-related symptoms at Uppsala University Hospital and Karolinska University Hospital between 1 March and 31 August 2020. The primary endpoint was COVID-19-related death and the secondary endpoint was to describe COVID-19 severity, defined as symptom severity (grades 0-4) and length of stay (LOS) at the university hospitals.\n\nIn total, 193 patients were included among which 31% died due to COVID-19 and 8% died of other causes. In a multivariable analysis, older age >70 (OR 3.6; 95% CI [1.8-7.3], p < 0.001) and male gender (OR 2.8 [1.4-5.8], p = 0.005) were factors associated with higher likelihood of COVID-19-related death. Several comorbidities \u22652 (OR 5.4 [2.0-14.3], p = 0.001) was independently associated with COVID-19 severity. Treatment with chemotherapy within 90 days prior to COVID-19 diagnosis were not associated with COVID-19-related death or severity.\n\nFactors associated with higher likelihood of COVID-19-related death were older age and male gender. More severe COVID-19 symptoms were seen in patients with multiple comorbidities. We did not see any associations between COVID-19-related death or severity and recent treatment including chemotherapy. In summary, this supports a thorough assessment regarding potential risks with COVID-19 infection in patients with cancer, with a combination of individual risk factors in addition to cancer treatments.", "doi": "10.1080/0284186X.2021.1958005", "pmid": "34334081", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-08-04T10:13:59.528Z", "modified": "2021-08-04T17:02:06.248Z"}, {"entity": "publication", "iuid": "0e0e178f9c3c43bea277a58e46ce4e94", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e0e178f9c3c43bea277a58e46ce4e94.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e0e178f9c3c43bea277a58e46ce4e94"}}, "title": "A phenomics approach for antiviral drug discovery.", "authors": [{"family": "Rietdijk", "given": "Jonne", "initials": "J"}, {"family": "Tampere", "given": "Marianna", "initials": "M"}, {"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Georgiev", "given": "Polina", "initials": "P"}, {"family": "Lapins", "given": "Maris", "initials": "M"}, {"family": "Warpman-Berglund", "given": "Ulrika", "initials": "U"}, {"family": "Spjuth", "given": "Ola", "initials": "O"}, {"family": "Puumalainen", "given": "Marjo-Riitta", "initials": "MR"}, {"family": "Carreras-Puigvert", "given": "Jordi", "initials": "J", "orcid": "0000-0002-7671-3707", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1fc481c38384cf78f24a490ec562e9a.json"}}], "type": "journal article", "published": "2021-08-02", "journal": {"title": "BMC Biol", "issn": "1741-7007", "issn-l": null, "volume": "19", "issue": "1", "pages": "156"}, "abstract": "The emergence and continued global spread of the current COVID-19 pandemic has highlighted the need for methods to identify novel or repurposed therapeutic drugs in a fast and effective way. Despite the availability of methods for the discovery of antiviral drugs, the majority tend to focus on the effects of such drugs on a given virus, its constituent proteins, or enzymatic activity, often neglecting the consequences on host cells. This may lead to partial assessment of the efficacy of the tested anti-viral compounds, as potential toxicity impacting the overall physiology of host cells may mask the effects of both viral infection and drug candidates. Here we present a method able to assess the general health of host cells based on morphological profiling, for untargeted phenotypic drug screening against viral infections.\n\nWe combine Cell Painting with antibody-based detection of viral infection in a single assay. We designed an image analysis pipeline for segmentation and classification of virus-infected and non-infected cells, followed by extraction of morphological properties. We show that this methodology can successfully capture virus-induced phenotypic signatures of MRC-5 human lung fibroblasts infected with human coronavirus 229E (CoV-229E). Moreover, we demonstrate that our method can be used in phenotypic drug screening using a panel of nine host- and virus-targeting antivirals. Treatment with effective antiviral compounds reversed the morphological profile of the host cells towards a non-infected state.\n\nThe phenomics approach presented here, which makes use of a modified Cell Painting protocol by incorporating an anti-virus antibody stain, can be used for the unbiased morphological profiling of virus infection on host cells. The method can identify antiviral reference compounds, as well as novel antivirals, demonstrating its suitability to be implemented as a strategy for antiviral drug repurposing and drug discovery.", "doi": "10.1186/s12915-021-01086-1", "pmid": "34334126", "labels": {"Funder: KAW/SciLifeLab": null, "Research Area: Drug discovery and repurposing of drugs": null, "Funder: VR": null, "Funder: H2020": null, "Category: Biochemistry": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8325993"}, {"db": "pii", "key": "10.1186/s12915-021-01086-1"}], "notes": [], "created": "2021-01-15T14:22:24.952Z", "modified": "2023-06-19T14:38:06.897Z"}, {"entity": "publication", "iuid": "eab92d11331949bda69a729bffc89d35", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eab92d11331949bda69a729bffc89d35.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eab92d11331949bda69a729bffc89d35"}}, "title": "Whether, when and how to extend unemployment benefits: Theory and application to COVID-19.", "authors": [{"family": "Mitman", "given": "Kurt", "initials": "K"}, {"family": "Rabinovich", "given": "Stanislav", "initials": "S"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "J Public Econ", "issn": "0047-2727", "issn-l": null, "volume": "200", "issue": null, "pages": "104447"}, "abstract": "We investigate the optimal response of unemployment insurance to economic shocks, both with and without commitment. The optimal policy with commitment follows a modified Baily-Chetty formula that accounts for job search responses to future UI benefit changes. As a result, the optimal policy with commitment tends to front-load UI, unlike the optimal discretionary policy. In response to shocks intended to mimic those that induced the COVID-19 recession, we find that a large and transitory increase in UI is optimal; and that a policy rule contingent on the change in unemployment, rather than its level, is a good approximation to the optimal policy.", "doi": "10.1016/j.jpubeco.2021.104447", "pmid": "34934254", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0047-2727(21)00083-9"}, {"db": "pmc", "key": "PMC8677353"}], "notes": [], "created": "2022-01-03T15:31:55.461Z", "modified": "2022-11-23T08:54:16.211Z"}, {"entity": "publication", "iuid": "3691196ee38a4d3986720e18d83fe719", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3691196ee38a4d3986720e18d83fe719.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3691196ee38a4d3986720e18d83fe719"}}, "title": "Towards a European strategy to address the COVID-19 pandemic", "authors": [{"family": "Priesemann", "given": "Viola", "initials": "V"}, {"family": "Balling", "given": "Rudi", "initials": "R"}, {"family": "Bauer", "given": "Simon", "initials": "S"}, {"family": "Beutels", "given": "Philippe", "initials": "P"}, {"family": "Valdez", "given": "Andr\u00e9 Calero", "initials": "AC"}, {"family": "Cuschieri", "given": "Sarah", "initials": "S"}, {"family": "Czypionka", "given": "Thomas", "initials": "T"}, {"family": "Dumpis", "given": "Uga", "initials": "U"}, {"family": "Glaab", "given": "Enrico", "initials": "E"}, {"family": "Grill", "given": "Eva", "initials": "E"}, {"family": "Hotulainen", "given": "Pirta", "initials": "P"}, {"family": "Iftekhar", "given": "Emil N", "initials": "EN"}, {"family": "Krutzinna", "given": "Jenny", "initials": "J"}, {"family": "Lionis", "given": "Christos", "initials": "C"}, {"family": "Machado", "given": "Helena", "initials": "H"}, {"family": "Martins", "given": "Carlos", "initials": "C"}, {"family": "McKee", "given": "Martin", "initials": "M"}, {"family": "Pavlakis", "given": "George N", "initials": "GN"}, {"family": "Perc", "given": "Matja\u017e", "initials": "M"}, {"family": "Petelos", "given": "Elena", "initials": "E"}, {"family": "Pickersgill", "given": "Martyn", "initials": "M"}, {"family": "Prainsack", "given": "Barbara", "initials": "B"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}, {"family": "Schernhammer", "given": "Eva", "initials": "E"}, {"family": "Szczurek", "given": "Ewa", "initials": "E"}, {"family": "Tsiodras", "given": "Sotirios", "initials": "S"}, {"family": "Van Gucht", "given": "Steven", "initials": "S"}, {"family": "Willeit", "given": "Peter", "initials": "P"}], "type": "journal-article", "published": "2021-08-00", "journal": {"title": "Lancet", "issn": "0140-6736", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/s0140-6736(21)01808-0", "pmid": null, "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-08-13T12:00:52.537Z", "modified": "2021-08-13T12:01:45.972Z"}, {"entity": "publication", "iuid": "cc82cb507a2a48c2a09b29e2c13b6cce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc82cb507a2a48c2a09b29e2c13b6cce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc82cb507a2a48c2a09b29e2c13b6cce"}}, "title": "The COVID-19 pandemic first wave in Sweden: A national registry study of the effects on pediatric anesthesia and surgery.", "authors": [{"family": "Melander", "given": "Sixten", "initials": "S"}, {"family": "Almstr\u00f6m", "given": "Jimmy", "initials": "J"}, {"family": "Enlund", "given": "Gunnar", "initials": "G", "orcid": "0000-0001-9438-3644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf636f1ef6744d0cbc4008ac4eb2e216.json"}}, {"family": "Frykholm", "given": "Peter", "initials": "P", "orcid": "0000-0001-6402-136X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/674a3d5efa544036a4b46bb6608ea28d.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Paediatr Anaesth", "issn": "1460-9592", "volume": "31", "issue": "8", "pages": "846-853", "issn-l": null}, "abstract": "The COVID-19 pandemic is pushing healthcare systems to their limits. Dramatic reductions in the adult elective surgery are ubiquitous, but corresponding changes in pediatric services are not well described. The Swedish Perioperative Registry contains data on all anesthetic procedures in Sweden, and therefore, provides a unique opportunity to analyze the effect of the pandemic on the pediatric anesthesia capacity on a national level. We hypothesized that there would be a significant reduction in pediatric elective procedures. The aim was to determine the effects on pediatric surgical and anesthetic services during the first wave of the COVID-19 pandemic in Sweden.\n\nFor this retrospective registry cohort study, we extracted all procedures performed on patients <18 years of age in 2020 and 2019. Weeks 12 to 26 of 2020 were defined as the first wave, and data were analyzed according to level of care, type of surgery, procedure code, and emergency or elective surgery.\n\nWe found 7015 fewer procedures during the first wave epoch. Elective cases were reduced by 53.7% while emergency surgery was not significantly affected. During the peak of the first wave in April, there was a 72.8% reduction in elective cases; ENT/maxillofacial surgery showed the greatest reduction (86.7%). The surgical and anesthesia capacity recovered to near-normal levels by the end of June 2020.\n\nWe conclude that the impact of COVID-19 on pediatric surgical procedures in Sweden during the first wave of the pandemic was dramatic, but elective services were restored a few months after the peak.", "doi": "10.1111/pan.14203", "pmid": "33971054", "labels": {"Type: Journal article": null, "Category: Health": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC8242453"}], "notes": [], "created": "2021-05-17T19:02:06.933Z", "modified": "2023-01-13T13:41:44.243Z"}, {"entity": "publication", "iuid": "dbeff85cff3047e0849558961640bf69", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dbeff85cff3047e0849558961640bf69.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dbeff85cff3047e0849558961640bf69"}}, "title": "Significant variations across European centres in implementing recommended guidelines for the paediatric gastroenterology endoscopy suite during the COVID-19 pandemic.", "authors": [{"family": "Athiana", "given": "Ilektra", "initials": "I"}, {"family": "L\u00e9geret", "given": "Corinne", "initials": "C"}, {"family": "Bontems", "given": "Patrick", "initials": "P"}, {"family": "Dall'Oglio", "given": "Luigi", "initials": "L"}, {"family": "De Angelis", "given": "Paola", "initials": "P"}, {"family": "Dias", "given": "Jorge Amil", "initials": "JA"}, {"family": "Hauser", "given": "Bruno", "initials": "B"}, {"family": "Homan", "given": "Matja\u017e", "initials": "M"}, {"family": "Narula", "given": "Priya", "initials": "P"}, {"family": "Norsa", "given": "Lorenzo", "initials": "L"}, {"family": "Oliva", "given": "Salvatore", "initials": "S"}, {"family": "Papadopoulou", "given": "Alexandra", "initials": "A"}, {"family": "Romano", "given": "Claudio", "initials": "C"}, {"family": "Thomson", "given": "Mike", "initials": "M"}, {"family": "Vila-Miravet", "given": "Victor", "initials": "V"}, {"family": "Furlano", "given": "Raoul I", "initials": "RI"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "JPGN Rep", "issn": "2691-171X", "volume": "2", "issue": "3", "pages": "e061", "issn-l": null}, "abstract": "The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) published recommendations regarding protection for the paediatric endoscopist during the coronavirus 2019 (COVID-19) pandemic.The aim of this survey was to investigate whether European paediatric gastroenterology centres applied the recommendations and how this extraordinary situation was handled by the different centres.\n\nTwelve paediatric European gastroenterology centres participated. Nine centres (75%) screened their patients for possible COVID-19 infection before the procedure, the same amount of hospitals changed their practice based on the ESPGHAN recommendations. Six-seven percentage of the centres reduced the staff in the endoscopy suite, 83% of the units used FFP2/3 masks and protective goggles during the procedure and 75% wore waterproof gowns.\n\nUniform guidelines could not be applied by all European hospitals at a certain time point of the viral spread, as different regions of Europe were not only affected differently by COVID-19, but also had different access to personal protective equipment.", "doi": "10.1097/PG9.0000000000000061", "pmid": "34192294", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8162040"}], "notes": [], "created": "2021-07-05T14:27:51.312Z", "modified": "2021-07-05T14:27:51.336Z"}, {"entity": "publication", "iuid": "8caa88f775e948a4bf6725d86b5850f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8caa88f775e948a4bf6725d86b5850f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8caa88f775e948a4bf6725d86b5850f2"}}, "title": "SARS-CoV-2 infections amongst personnel providing home care services for older persons in Stockholm, Sweden.", "authors": [{"family": "Hassan", "given": "S S", "initials": "SS"}, {"family": "Seigerud", "given": "\u00c5", "initials": "\u00c5"}, {"family": "Abdirahman", "given": "R", "initials": "R"}, {"family": "Arroyo M\u00fchr", "given": "L S", "initials": "LS"}, {"family": "Nordqvist Kleppe", "given": "S", "initials": "S"}, {"family": "Pin", "given": "E", "initials": "E"}, {"family": "M\u00e5nberg", "given": "A", "initials": "A"}, {"family": "Hober", "given": "S", "initials": "S"}, {"family": "Nilsson", "given": "P", "initials": "P"}, {"family": "Engstrand", "given": "L", "initials": "L"}, {"family": "Miriam Elfstr\u00f6m", "given": "K", "initials": "K"}, {"family": "Blomqvist", "given": "J", "initials": "J"}, {"family": "Conneryd Lundgren", "given": "K", "initials": "K"}, {"family": "Dillner", "given": "J", "initials": "J", "orcid": "0000-0001-8588-6506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bbb8b0ca5dc648e0b80c1de224b26c69.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": "290", "issue": "2", "pages": "430-436"}, "abstract": "In Sweden, home care services is a major external contact for older persons.\n\nFive home care service companies in Stockholm, Sweden, enrolled 405 employees to a study including serum IgG to SARS-CoV-2 and SARS-CoV-2 virus in throat swabs.\n\n20.1% (81/403) of employees were seropositive, about twice as many as in a simultaneously enrolled reference population (healthcare workers entirely without patient contact, n = 3671; 9.7% seropositivity). 13/379 employees (3.4%) had a current infection (PCR positivity). Amongst these, 5 were also seropositive and 3 were positive with low amounts of virus. High amounts of virus and no antibodies (a characteristic for presymptomatic COVID-19) were present in 5 employees (1.3%).\n\nPersonnel providing home services for older persons appear to be a risk group for SARS-CoV-2. Likely presymptomatic employees can be readily identified by screening. Increased protection of employees and of the older persons they serve is warranted.", "doi": "10.1111/joim.13274", "pmid": "33843090", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Serology": null}, "xrefs": [{"db": "pmc", "key": "PMC8250663"}], "notes": [], "created": "2021-04-13T10:17:03.259Z", "modified": "2021-11-18T16:00:16.404Z"}, {"entity": "publication", "iuid": "7d609c06c1ab41a1bb9dbd6937403c84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d609c06c1ab41a1bb9dbd6937403c84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d609c06c1ab41a1bb9dbd6937403c84"}}, "title": "Risk factors for the delayed viral clearance in COVID-19 patients.", "authors": [{"family": "Chen", "given": "Xiaoping", "initials": "X"}, {"family": "Hu Mt", "given": "Wenjia", "initials": "W"}, {"family": "Yang", "given": "Miao", "initials": "M"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Zhang", "given": "Yongxi", "initials": "Y"}, {"family": "Deng", "given": "Liping", "initials": "L"}, {"family": "Li", "given": "Jinlin", "initials": "J"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Lindahl", "given": "Johanna F", "initials": "JF"}, {"family": "Xiong", "given": "Yong", "initials": "Y", "orcid": "0000-0003-0678-4064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37777ebb9bda45caa57a6c39ebd17ded.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "J Clin Hypertens (Greenwich)", "issn": "1751-7176", "issn-l": "1524-6175", "volume": "23", "issue": "8", "pages": "1483-1489"}, "abstract": "Comorbidities are important for the disease outcome of COVID-19, however, which underlying diseases that contribute the most to aggravate the conditions of COVID-19 patients are still unclear. Viral clearance is the most important laboratory test for defining the recovery of COVID-19 infections. To better understand which underlying diseases that are risk factors for delaying the viral clearance, we retrospectively analyzed 161 COVID-19 clinical cases in the Zhongnan Hospital of Wuhan University, Wuhan, China between January 5 and March 13, 2020. The demographic, clinical and laboratory data, as well as patient treatment records were collected. Univariable and multivariable analysis were performed to explore the association between delayed viral clearance and other factors by using logistic regression. Survival analyses by Kaplan-Meier and Cox regression modeling were employed to identify factors negatively influencing the viral clearance negatively. We found that hypertension and intravenous immunoglobulin adversely affected the time of viral RNA shedding. Hypertension was the most important risk factor to delay the SARS-CoV-2 virus clearance, however, the use of Angiotensin-Converting Enzyme Inhibitors(ACEI)/Angiotensin Receptor Blockers(ARB) did not shorten the time for virus clearance in these hypertensive patients' virus clearance. We conclude that patients having hypertension and intravenous immunoglobulin may delay the viral clearance in COVID-19 patients.", "doi": "10.1111/jch.14308", "pmid": "34171164", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8420571"}], "notes": [], "created": "2021-06-28T18:00:36.406Z", "modified": "2023-06-19T15:32:23.071Z"}, {"entity": "publication", "iuid": "d5aeef1eb51f47d7b04cd19fa4379b3c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5aeef1eb51f47d7b04cd19fa4379b3c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5aeef1eb51f47d7b04cd19fa4379b3c"}}, "title": "Rapid Exclusion of COVID Infection With the Artificial Intelligence Electrocardiogram.", "authors": [{"family": "Attia", "given": "Zachi I", "initials": "ZI"}, {"family": "Kapa", "given": "Suraj", "initials": "S"}, {"family": "Dugan", "given": "Jennifer", "initials": "J"}, {"family": "Pereira", "given": "Naveen", "initials": "N"}, {"family": "Noseworthy", "given": "Peter A", "initials": "PA"}, {"family": "Jimenez", "given": "Francisco Lopez", "initials": "FL"}, {"family": "Cruz", "given": "Jessica", "initials": "J"}, {"family": "Carter", "given": "Rickey E", "initials": "RE"}, {"family": "DeSimone", "given": "Daniel C", "initials": "DC"}, {"family": "Signorino", "given": "John", "initials": "J"}, {"family": "Halamka", "given": "John", "initials": "J"}, {"family": "Chennaiah Gari", "given": "Nikhita R", "initials": "NR"}, {"family": "Madathala", "given": "Raja Sekhar", "initials": "RS"}, {"family": "Platonov", "given": "Pyotr G", "initials": "PG"}, {"family": "Gul", "given": "Fahad", "initials": "F"}, {"family": "Janssens", "given": "Stefan P", "initials": "SP"}, {"family": "Narayan", "given": "Sanjiv", "initials": "S"}, {"family": "Upadhyay", "given": "Gaurav A", "initials": "GA"}, {"family": "Alenghat", "given": "Francis J", "initials": "FJ"}, {"family": "Lahiri", "given": "Marc K", "initials": "MK"}, {"family": "Dujardin", "given": "Karl", "initials": "K"}, {"family": "Hermel", "given": "Melody", "initials": "M"}, {"family": "Dominic", "given": "Paari", "initials": "P"}, {"family": "Turk-Adawi", "given": "Karam", "initials": "K"}, {"family": "Asaad", "given": "Nidal", "initials": "N"}, {"family": "Svensson", "given": "Anneli", "initials": "A"}, {"family": "Fernandez-Aviles", "given": "Francisco", "initials": "F"}, {"family": "Esakof", "given": "Darryl D", "initials": "DD"}, {"family": "Bartunek", "given": "Jozef", "initials": "J"}, {"family": "Noheria", "given": "Amit", "initials": "A"}, {"family": "Sridhar", "given": "Arun R", "initials": "AR"}, {"family": "Lanza", "given": "Gaetano A", "initials": "GA"}, {"family": "Cohoon", "given": "Kevin", "initials": "K"}, {"family": "Padmanabhan", "given": "Deepak", "initials": "D"}, {"family": "Pardo Gutierrez", "given": "Jose Alberto", "initials": "JA"}, {"family": "Sinagra", "given": "Gianfranco", "initials": "G"}, {"family": "Merlo", "given": "Marco", "initials": "M"}, {"family": "Zagari", "given": "Domenico", "initials": "D"}, {"family": "Rodriguez Escenaro", "given": "Brenda D", "initials": "BD"}, {"family": "Pahlajani", "given": "Dev B", "initials": "DB"}, {"family": "Loncar", "given": "Goran", "initials": "G"}, {"family": "Vukomanovic", "given": "Vladan", "initials": "V"}, {"family": "Jensen", "given": "Henrik K", "initials": "HK"}, {"family": "Farkouh", "given": "Michael E", "initials": "ME"}, {"family": "Luescher", "given": "Thomas F", "initials": "TF"}, {"family": "Su Ping", "given": "Carolyn Lam", "initials": "CL"}, {"family": "Peters", "given": "Nicholas S", "initials": "NS"}, {"family": "Friedman", "given": "Paul A", "initials": "PA"}, {"family": "Discover Consortium (Digital and Noninvasive Screening for COVID-19 with AI ECG Repository)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Mayo Clin Proc", "issn": "1942-5546", "volume": "96", "issue": "8", "pages": "2081-2094", "issn-l": "0025-6196"}, "abstract": "To rapidly exclude severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection using artificial intelligence applied to the electrocardiogram (ECG).\n\nA global, volunteer consortium from 4 continents identified patients with ECGs obtained around the time of polymerase chain reaction-confirmed COVID-19 diagnosis and age- and sex-matched controls from the same sites. Clinical characteristics, polymerase chain reaction results, and raw electrocardiographic data were collected. A convolutional neural network was trained using 26,153 ECGs (33.2% COVID positive), validated with 3826 ECGs (33.3% positive), and tested on 7870 ECGs not included in other sets (32.7% positive). Performance under different prevalence values was tested by adding control ECGs from a single high-volume site.\n\nThe area under the curve for detection of acute COVID-19 infection in the test group was 0.767 (95% CI, 0.756 to 0.778; sensitivity, 98%; specificity, 10%; positive predictive value, 37%; negative predictive value, 91%). To more accurately reflect a real-world population, 50,905 normal controls were added to adjust the COVID prevalence to approximately 5% (2657/58,555), resulting in an area under the curve of 0.780 (95% CI, 0.771 to 0.790) with a specificity of 12.1% and a negative predictive value of 99.2%.\n\nInfection with SARS-CoV-2 results in electrocardiographic changes that permit the artificial intelligence-enhanced ECG to be used as a rapid screening test with a high negative predictive value (99.2%). This may permit the development of electrocardiography-based tools to rapidly screen individuals for pandemic control.", "doi": "10.1016/j.mayocp.2021.05.027", "pmid": "34353468", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0025-6196(21)00469-9"}, {"db": "pmc", "key": "PMC8327278"}], "notes": [], "created": "2021-08-11T14:41:45.678Z", "modified": "2021-08-11T14:41:45.689Z"}, {"entity": "publication", "iuid": "b1a31e2f8897420b92fc5124af260100", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1a31e2f8897420b92fc5124af260100.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1a31e2f8897420b92fc5124af260100"}}, "title": "Psychological distress among health professional students during the COVID-19 outbreak", "authors": [{"family": "Li", "given": "Yuchen", "initials": "Y"}, {"family": "Wang", "given": "Yue", "initials": "Y"}, {"family": "Jiang", "given": "Jingwen", "initials": "J"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA", "orcid": "0000-0001-5382-946X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87d1dbec7c6f4942b1db2b999eeb9ece.json"}}, {"family": "Fall", "given": "Katja", "initials": "K", "orcid": "0000-0002-3649-2639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa0adf9b952e4e998c4a2deb07be5907.json"}}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Song", "given": "Huan", "initials": "H"}, {"family": "Lu", "given": "Donghao", "initials": "D"}, {"family": "Zhang", "given": "Wei", "initials": "W", "orcid": "0000-0003-3113-9577", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3cc118af29054fc59971e82c3a711740.json"}}], "type": "journal-article", "published": "2021-08-00", "journal": {"title": "Psychol Med", "issn": "0033-2917", "issn-l": null, "volume": "51", "issue": "11", "pages": "1952-1954"}, "abstract": "Due to the drastic surge of COVID-19 patients, many countries are considering or already graduating health professional students early to aid professional resources. We aimed to assess outbreak-related psychological distress and symptoms of acute stress reaction (ASR) in health professional students and to characterize individuals with potential need for interventions.\n\nWe conducted a prospective cohort study of 1442 health professional students at Sichuan University, China. At baseline (October 2019), participants were assessed for childhood adversity, stressful life events, internet addiction, and family functioning. Using multivariable logistic regression, we examined associations of the above exposures with subsequent psychological distress and ASR in response to the outbreak.\n\nThree hundred and eighty-four (26.63%) participants demonstrated clinically significant psychological distress, while 160 (11.10%) met the criterion for a probable ASR. Individuals who scored high on both childhood adversity and stressful life event experiences during the past year were at increased risks of both distress (ORs 2.00-2.66) and probable ASR (ORs 2.23-3.10), respectively. Moreover, internet addiction was associated with elevated risks of distress (OR 2.05, 95% CI 1.60-2.64) and probable ASR (OR 2.15, 95% CI 1.50-3.10). By contrast, good family functioning was associated with decreased risks of distress (OR 0.43, 95% CI 0.33-0.55) and probable ASR (OR 0.48, 95% CI 0.33-0.69). All associations were independent of baseline psychological distress.\n\nOur findings suggest that COVID-19 related psychological distress and high symptoms burden of ASR are common among health professional students. Extended family and professional support should be considered for vulnerable individuals during these unprecedented times.", "doi": "10.1017/s0033291720001555", "pmid": "32389148", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0033291720001555"}, {"db": "pmc", "key": "PMC7225209"}], "notes": [], "created": "2020-11-25T07:53:07.503Z", "modified": "2021-12-06T13:10:39.089Z"}, {"entity": "publication", "iuid": "e6e339fe0d2a4d418964a3c67e2f51f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6e339fe0d2a4d418964a3c67e2f51f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6e339fe0d2a4d418964a3c67e2f51f8"}}, "title": "Plasma ACE2 species are differentially altered in COVID-19 patients.", "authors": [{"family": "Garc\u00eda-Ayll\u00f3n", "given": "Mar\u00eda-Salud", "initials": "MS"}, {"family": "Moreno-P\u00e9rez", "given": "Oscar", "initials": "O"}, {"family": "Garc\u00eda-Arriaza", "given": "Juan", "initials": "J"}, {"family": "Ramos-Rinc\u00f3n", "given": "Jos\u00e9-Manuel", "initials": "JM"}, {"family": "Cort\u00e9s-G\u00f3mez", "given": "Mar\u00eda-\u00c1ngeles", "initials": "M\u00c1"}, {"family": "Brinkmalm", "given": "Gunnar", "initials": "G"}, {"family": "Andr\u00e9s", "given": "Mariano", "initials": "M"}, {"family": "Le\u00f3n-Ram\u00edrez", "given": "Jos\u00e9-Manuel", "initials": "JM"}, {"family": "Boix", "given": "Vicente", "initials": "V"}, {"family": "Gil", "given": "Joan", "initials": "J"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Esteban", "given": "Mariano", "initials": "M"}, {"family": "Merino", "given": "Esperanza", "initials": "E"}, {"family": "S\u00e1ez-Valero", "given": "Javier", "initials": "J", "orcid": "0000-0001-7480-320X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/848e18c69576492a91a7aa35cee7f632.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "FASEB J", "issn": "1530-6860", "volume": "35", "issue": "8", "pages": "e21745", "issn-l": null}, "abstract": "Studies are needed to identify useful biomarkers to assess the severity and prognosis of COVID-19 disease, caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) virus. Here, we examine the levels of various plasma species of the SARS-CoV-2 host receptor, the angiotensin-converting enzyme 2 (ACE2), in patients at different phases of the infection. Human plasma ACE2 species were characterized by immunoprecipitation and western blotting employing antibodies against the ectodomain and the C-terminal domain, using a recombinant human ACE2 protein as control. In addition, changes in the cleaved and full-length ACE2 species were also examined in serum samples derived from humanized K18-hACE2 mice challenged with a lethal dose of SARS-CoV-2. ACE2 immunoreactivity was present in human plasma as several molecular mass species that probably comprise truncated (70 and 75 kDa) and full-length forms (95, 100, 130, and 170 kDa). COVID-19 patients in the acute phase of infection (n = 46) had significantly decreased levels of ACE2 full-length species, while a truncated 70-kDa form was marginally higher compared with non-disease controls (n = 26). Levels of ACE2 full-length species were in the normal range in patients after a recovery period with an interval of 58-70 days (n = 29), while the 70-kDa species decreased. Levels of the truncated ACE2 species served to discriminate between individuals infected by SARS-CoV-2 and those infected with influenza A virus (n = 17). In conclusion, specific plasma ACE2 species are altered in patients with COVID-19 and these changes normalize during the recovery phase. Alterations in ACE2 species following SARS-CoV-2 infection warrant further investigation regarding their potential usefulness as biomarkers for the disease process and to asses efficacy during vaccination.", "doi": "10.1096/fj.202100051R", "pmid": "34191346", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-07-05T14:25:00.186Z", "modified": "2021-07-05T14:25:00.235Z"}, {"entity": "publication", "iuid": "c9a99007569a4d118c6ea72f0552fe9f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9a99007569a4d118c6ea72f0552fe9f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9a99007569a4d118c6ea72f0552fe9f"}}, "title": "Neurochemical signs of astrocytic and neuronal injury in acute COVID-19 normalizes during long-term follow-up.", "authors": [{"family": "Kanberg", "given": "Nelly", "initials": "N", "orcid": "0000-0002-1064-995X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84d593bfda8f42688e9d4fe713158679.json"}}, {"family": "Simr\u00e9n", "given": "Joel", "initials": "J", "orcid": "0000-0001-5081-6604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00690c8e16a545aea824cdf580837500.json"}}, {"family": "Ed\u00e9n", "given": "Arvid", "initials": "A"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ"}, {"family": "Sundvall", "given": "P\u00e4r-Daniel", "initials": "PD"}, {"family": "Nellg\u00e5rd", "given": "Bengt", "initials": "B"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": "70", "issue": null, "pages": "103512"}, "abstract": "Neurologic manifestations are well-recognized features of coronavirus disease 2019 (COVID-19). However, the longitudinal association of biomarkers reflecting CNS impact and neurological symptoms is not known. We sought to determine whether plasma biomarkers of CNS injury were associated with neurologic sequelae after COVID-19.\n\nPatients with confirmed acute COVID-19 were studied prospectively. Neurological symptoms were recorded during the acute phase of the disease and at six months follow-up, and blood samples were collected longitudinally. Healthy age-matched individuals were included as controls. We analysed plasma concentrations of neurofilament light-chain (NfL), glial fibrillary acidic protein (GFAp), and growth differentiation factor 15 (GDF-15).\n\nOne hundred patients with mild (n = 24), moderate (n = 28), and severe (n = 48) COVID-19 were followed for a median (IQR) of 225 (187-262) days. In the acute phase, patients with severe COVID-19 had higher concentrations of NfL than all other groups (all p < 0\u00b7001), and higher GFAp than controls (p < 0\u00b7001). GFAp was also significantly increased in moderate disease (p < 0\u00b705) compared with controls. NfL (r = 0\u00b753, p < 0\u00b7001) and GFAp (r = 0\u00b739, p < 0\u00b7001) correlated with GDF-15 during the acute phase. After six months, NfL and GFAp concentrations had normalized, with no persisting group differences. Despite this, 50 patients reported persistent neurological symptoms, most commonly fatigue (n = 40), \"brain-fog\" (n = 29), and changes in cognition (n = 25). We found no correlation between persistent neurological symptoms and CNS injury biomarkers in the acute phase.\n\nThe normalization of CNS injury biomarkers in all individuals, regardless of previous disease severity or persisting neurological symptoms, indicates that post COVID-19 neurological sequelae are not accompanied by ongoing CNS injury.\n\nThe Swedish State Support for Clinical Research, SciLifeLab Sweden, and the Knut and Alice Wallenberg Foundation have provided funding for this project.", "doi": "10.1016/j.ebiom.2021.103512", "pmid": "34333238", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pmc", "key": "PMC8320425"}, {"db": "pii", "key": "S2352-3964(21)00305-4"}], "notes": [], "created": "2021-08-04T10:16:45.714Z", "modified": "2023-06-19T14:46:01.082Z"}, {"entity": "publication", "iuid": "6ee34e8dbbdc4f9ea7f914fddabc947a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ee34e8dbbdc4f9ea7f914fddabc947a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ee34e8dbbdc4f9ea7f914fddabc947a"}}, "title": "Natural killer cells and unconventional T cells in COVID-19", "authors": [{"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Ponzetta", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3224-802X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8d6bca49dc24e558ca8f0b3637d7702.json"}}], "type": "journal-article", "published": "2021-08-00", "journal": {"title": "Current Opinion in Virology", "issn": "1879-6257", "issn-l": null, "volume": "49", "issue": null, "pages": "176-182"}, "abstract": null, "doi": "10.1016/j.coviro.2021.06.005", "pmid": "34217135", "labels": {"Type: Review": null, "Funder: VR": null, "Funder: H2020": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [], "notes": [], "created": "2021-06-21T05:55:32.100Z", "modified": "2021-12-12T18:08:46.036Z"}, {"entity": "publication", "iuid": "8425f513719f4c8c92b50fc93ef47bc4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8425f513719f4c8c92b50fc93ef47bc4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8425f513719f4c8c92b50fc93ef47bc4"}}, "title": "Measuring oxygen access: lessons from health facility assessments in Lagos, Nigeria.", "authors": [{"family": "Graham", "given": "Hamish R", "initials": "HR", "orcid": "0000-0003-2461-0463", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d2d23d0b7dc40f3979a4342d3898649.json"}}, {"family": "Olojede", "given": "Omotayo E", "initials": "OE"}, {"family": "Bakare", "given": "Ayobami A", "initials": "AA"}, {"family": "Iuliano", "given": "Agnese", "initials": "A"}, {"family": "Olatunde", "given": "Oyaniyi", "initials": "O"}, {"family": "Isah", "given": "Adamu", "initials": "A"}, {"family": "Osebi", "given": "Adams", "initials": "A"}, {"family": "Ahmed", "given": "Tahlil", "initials": "T"}, {"family": "Uchendu", "given": "Obioma C", "initials": "OC"}, {"family": "Burgess", "given": "Rochelle", "initials": "R", "orcid": "0000-0001-9749-7065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f890d7dbdea04ac09c689b6c612baa26.json"}}, {"family": "McCollum", "given": "Eric", "initials": "E"}, {"family": "Colbourn", "given": "Tim", "initials": "T", "orcid": "0000-0002-6917-6552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2cccce75e4b4602ab197604cb444a0a.json"}}, {"family": "King", "given": "Carina", "initials": "C", "orcid": "0000-0002-6885-6716", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8ac349483b74803a39b937bf149c480.json"}}, {"family": "Falade", "given": "Adegoke G", "initials": "AG"}, {"family": "INSPIRING Project Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "8", "issn-l": "2059-7908"}, "abstract": "The COVID-19 pandemic has highlighted global oxygen system deficiencies and revealed gaps in how we understand and measure 'oxygen access'. We present a case study on oxygen access from 58 health facilities in Lagos state, Nigeria. We found large differences in oxygen access between facilities (primary vs secondary, government vs private) and describe three key domains to consider when measuring oxygen access: availability, cost, use. Of 58 facilities surveyed, 8 (14%) of facilities had a functional pulse oximeter. Oximeters (N=27) were typically located in outpatient clinics (12/27, 44%), paediatric ward (6/27, 22%) or operating theatre (4/27, 15%). 34/58 (59%) facilities had a functional source of oxygen available on the day of inspection, of which 31 (91%) facilities had it available in a single ward area, typically the operating theatre or maternity ward. Oxygen services were free to patients at primary health centres, when available, but expensive in hospitals and private facilities, with the median cost for 2 days oxygen 13 000 (US$36) and 27 500 (US$77) Naira, respectively. We obtained limited data on the cost of oxygen services to facilities. Pulse oximetry use was low in secondary care facilities (32%, 21/65 patients had SpO2 documented) and negligible in private facilities (2%, 3/177) and primary health centres (<1%, 2/608). We were unable to determine the proportion of hypoxaemic patients who received oxygen therapy with available data. However, triangulation of existing data suggested that no facilities were equipped to meet minimum oxygen demands. We highlight the importance of a multifaceted approach to measuring oxygen access that assesses access at the point-of-care and ideally at the patient-level. We propose standard metrics to report oxygen access and describe how these can be integrated into routine health information systems and existing health facility assessment tools.", "doi": "10.1136/bmjgh-2021-006069", "pmid": "34344666", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-006069"}], "notes": [], "created": "2021-08-06T09:49:48.615Z", "modified": "2021-08-06T09:51:35.891Z"}, {"entity": "publication", "iuid": "1d66b977d13240398ce77404977f48d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d66b977d13240398ce77404977f48d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d66b977d13240398ce77404977f48d7"}}, "title": "Low admission protein C levels are a risk factor for disease worsening and mortality in hospitalized patients with COVID-19", "authors": [{"family": "Stanne", "given": "Tara M", "initials": "TM"}, {"family": "Pedersen", "given": "Annie", "initials": "A"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Jern", "given": "Christina", "initials": "C"}], "type": "journal-article", "published": "2021-08-00", "journal": {"title": "Thromb Res", "issn": "0049-3848", "volume": "204", "issue": null, "pages": "13-15", "issn-l": null}, "abstract": null, "doi": "10.1016/j.thromres.2021.05.016", "pmid": "34102452", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [], "notes": [], "created": "2021-06-09T19:02:28.905Z", "modified": "2021-06-10T10:15:42.634Z"}, {"entity": "publication", "iuid": "92f2c01548f4465b9ea64f67b973df7d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/92f2c01548f4465b9ea64f67b973df7d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/92f2c01548f4465b9ea64f67b973df7d"}}, "title": "Impact of the Alpha VOC on disease severity in SARS-CoV-2-positive adults in Sweden", "authors": [{"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-8801-3169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37509c3832244b019b91a1fe2cbe183e.json"}}, {"family": "Bruce", "given": "Daniel", "initials": "D"}, {"family": "Wahlstr\u00f6m", "given": "Erik", "initials": "E", "orcid": "0000-0002-0800-8520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f623177f84a4f4ba85571b106e4cec5.json"}}, {"family": "Walther", "given": "Sten", "initials": "S", "orcid": "0000-0002-3862-2556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f835267776274befa3013a432790de71.json"}}, {"family": "Carnahan", "given": "Moa Rehn, AnnaSara", "initials": "MRA", "orcid": "0000-0002-3940-4323", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ce1cef1f776424a977f2e21f38ff05e.json"}}, {"family": "Andersson", "given": "Emmi", "initials": "E"}, {"family": "Bark", "given": "Anna M Bennet", "initials": "AMB", "orcid": "0000-0003-2704-2625", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa79f4ac2db849368192a91c01cd370a.json"}}, {"family": "Hanberger", "given": "H\u00e5kan", "initials": "H", "orcid": "0000-0002-4199-0229", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ccccceb630874fc5ab7507a313b59039.json"}}], "type": "journal-article", "published": "2021-08-00", "journal": {"title": "J Infect", "issn": "0163-4453", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jinf.2021.08.043", "pmid": "34474056", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "S0163-4453(21)00448-5"}, {"db": "pmc", "key": "PMC8405243"}], "notes": [], "created": "2021-09-06T06:05:00.631Z", "modified": "2021-11-19T11:22:16.947Z"}, {"entity": "publication", "iuid": "fbc72c1d65a94e25b57a9ba3da49b44c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fbc72c1d65a94e25b57a9ba3da49b44c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fbc72c1d65a94e25b57a9ba3da49b44c"}}, "title": "Fostering healthy aging: The interdependency of infections, immunity and frailty.", "authors": [{"family": "Vetrano", "given": "Davide L", "initials": "DL", "orcid": "0000-0002-3099-4830", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0124721bb214413a34c965b6accc64b.json"}}, {"family": "Triolo", "given": "Federico", "initials": "F"}, {"family": "Maggi", "given": "Stefania", "initials": "S"}, {"family": "Malley", "given": "Richard", "initials": "R"}, {"family": "Jackson", "given": "Thomas A", "initials": "TA"}, {"family": "Poscia", "given": "Andrea", "initials": "A", "orcid": "0000-0002-7616-3389", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0a468effc7749f193226a16c27c7b18.json"}}, {"family": "Bernabei", "given": "Roberto", "initials": "R"}, {"family": "Ferrucci", "given": "Luigi", "initials": "L"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Ageing Res Rev", "issn": "1872-9649", "volume": "69", "issue": null, "pages": "101351", "issn-l": "1568-1637"}, "abstract": "Untangling the interdependency of infections, immunity and frailty may help to clarify their roles in the maintenance of health in aging individuals, and the recent COVID-19 pandemic has further highlighted such priority. In this scoping review we aimed to systematically collect the evidence on 1) the impact of common infections such as influenza, pneumonia and varicella zoster on frailty development, and 2) the role played by frailty in the response to immunization of older adults. Findings are discussed under a unifying framework to identify knowledge gaps and outline their clinical and public health implications to foster a healthier aging. Twenty-nine studies (113,863 participants) selected to answer the first question provided a moderately strong evidence of an association between infections and physical as well as cognitive decline - two essential dimensions of frailty. Thirteen studies (34,520 participants) investigating the second aim, showed that frailty was associated with an impaired immune response in older ages, likely due to immunosenescence. However, the paucity of studies, the absence of tools to predict vaccine efficacy, and the lack of studies investigating the efficacy of newer vaccines in presence of frailty, strongly limit the formulation of more personalized immunization strategies for older adults. The current evidence suggests that infections and frailty repeatedly cross each other pathophysiological paths and accelerate the aging process in a vicious circle. Such evidence opens to several considerations. First, the prevention of both conditions pass through a life course approach, which includes several individual and societal aspects. Second, the maintenance of a well-functioning immune system may be accomplished by preventing frailty, and vice versa. Third, increasing the adherence to immunization may delay the onset of frailty and maintain the immune system homeostasis, beyond preventing infections.", "doi": "10.1016/j.arr.2021.101351", "pmid": "33971332", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC9588151"}, {"db": "pii", "key": "S1568-1637(21)00098-2"}], "notes": [], "created": "2021-05-17T19:01:01.504Z", "modified": "2023-06-19T15:29:33.054Z"}, {"entity": "publication", "iuid": "e2899a4f5e3b42c58bf8868d706a73db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2899a4f5e3b42c58bf8868d706a73db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2899a4f5e3b42c58bf8868d706a73db"}}, "title": "Evidence-based public policy making for medicines across countries: findings and implications for the future.", "authors": [{"family": "Godman", "given": "Brian", "initials": "B", "orcid": "0000-0001-6539-6972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e76103610619453b84eab8de36f169cc.json"}}, {"family": "Fadare", "given": "Joseph", "initials": "J", "orcid": "0000-0002-5641-1402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0cd3e8ea7e09469ab822edbaa7f57830.json"}}, {"family": "Kwon", "given": "Hye-Young", "initials": "HY", "orcid": "0000-0001-9772-1354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/935f3f4bd268497aa8bfb936216ab36e.json"}}, {"family": "Dias", "given": "Carolina Zampirolli", "initials": "CZ", "orcid": "0000-0003-2181-4268", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d27ffebfe3ca4a61a66559b3e9927fc9.json"}}, {"family": "Kurdi", "given": "Amanj", "initials": "A", "orcid": "0000-0001-5036-1988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be9bf17786754363929dc0faaae8c323.json"}}, {"family": "Dias God\u00f3i", "given": "Isabella Piassi", "initials": "IP", "orcid": "0000-0002-0568-6625", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6ade8b9c4e94a64add5b0d5b6911a27.json"}}, {"family": "Kibuule", "given": "Dan", "initials": "D", "orcid": "0000-0002-6908-2177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4344137451d04535a5875183b9abc24e.json"}}, {"family": "Hoxha", "given": "Iris", "initials": "I"}, {"family": "Opanga", "given": "Sylvia", "initials": "S"}, {"family": "Saleem", "given": "Zikria", "initials": "Z", "orcid": "0000-0003-3202-6347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/029d4b30cc724148a1225090d3f063ee.json"}}, {"family": "Bochenek", "given": "Tomasz", "initials": "T", "orcid": "0000-0001-9915-7267", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce6242842ee44d19808be95b7a3196d3.json"}}, {"family": "Markovi\u0107-Pekovi\u0107", "given": "Vanda", "initials": "V", "orcid": "0000-0001-8963-5720", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb251c8af64542caa7bb5728b7348ef7.json"}}, {"family": "Mardare", "given": "Ileana", "initials": "I", "orcid": "0000-0002-4725-9808", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d95ddb606d24f5099c75a2e9f8db778.json"}}, {"family": "Kalungia", "given": "Aubrey C", "initials": "AC", "orcid": "0000-0003-2554-1236", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d9dffebafbd4ac2ba111bdb7b32876d.json"}}, {"family": "Campbell", "given": "Stephen", "initials": "S", "orcid": "0000-0002-2328-4136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ca866e1934246d1a368303f3cd026b5.json"}}, {"family": "Allocati", "given": "Eleonora", "initials": "E"}, {"family": "Pisana", "given": "Alice", "initials": "A"}, {"family": "Martin", "given": "Antony P", "initials": "AP", "orcid": "0000-0003-4383-6038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6a0ea83af464d6fa0ec04b3e333fcab.json"}}, {"family": "Meyer", "given": "Johanna C", "initials": "JC", "orcid": "0000-0003-0462-5713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b517b46322e64403aee5b49f60da3ac4.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "J Comp Eff Res", "issn": "2042-6313", "volume": "10", "issue": "12", "pages": "1019-1052", "issn-l": null}, "abstract": "Aim: Global expenditure on medicines is rising up to 6% per year driven by increasing prevalence of non-communicable diseases (NCDs) and new premium priced medicines for cancer, orphan diseases and other complex areas. This is difficult to sustain without reforms. Methods: Extensive narrative review of published papers and contextualizing the findings to provide future guidance. Results: New models are being introduced to improve the managed entry of new medicines including managed entry agreements, fair pricing approaches and monitoring prescribing against agreed guidance. Multiple measures have also successfully been introduced to improve the prescribing of established medicines. This includes encouraging greater prescribing of generics and biosimilars versus originators and patented medicines in a class to conserve resources without compromising care. In addition, reducing inappropriate antibiotic utilization. Typically, multiple measures are the most effective. Conclusion: Multiple measures will be needed to attain and retain universal healthcare.", "doi": "10.2217/cer-2020-0273", "pmid": "34241546", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:59:09.733Z", "modified": "2021-08-06T07:59:09.998Z"}, {"entity": "publication", "iuid": "8af2b1eadc0942f19199db9b059a446b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8af2b1eadc0942f19199db9b059a446b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8af2b1eadc0942f19199db9b059a446b"}}, "title": "Emotions during the Covid-19 pandemic: Fear, anxiety, and anger as mediators between threats and policy support and political actions.", "authors": [{"family": "Renstr\u00f6m", "given": "Emma A", "initials": "EA", "orcid": "0000-0001-6593-2464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c969b46ee25b4276916587537076440c.json"}}, {"family": "B\u00e4ck", "given": "Hanna", "initials": "H"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "J Appl Soc Psychol", "issn": "0021-9029", "issn-l": null, "volume": "51", "issue": "8", "pages": "861-877"}, "abstract": "The Covid-19 pandemic has significantly changed the lives of most people. It has been described as the most severe global health disaster of modern times by the United Nations. No doubt such a major crisis influences what citizens think of different policies, and how they become politically active, not to mention, the forceful emotional experiences that the Covid-19 pandemic brings. This study evaluates how emotions affect support for policies related to restricting the spread of the virus and economic assistance, and how emotions affect intentions to engage politically. In an experiment (N = 1,072), we manipulated emotional reactions to threat by highlighting different aspects of the pandemic. Our findings show that different experimental treatments elicit different emotions, and that fear, anxiety, and anger are all related to policy support and political action intentions, but in different ways. Fear and anger predict support for restrictive policies to limit the spread of the virus, while anxiety predicts support for economic policies. Anger and anxiety, but not fear, increase intentions to engage politically. Hence, we find support for a mechanism where different aspects of the Covid-19 crisis evoke different emotional reactions, which in turn affects policy support and political actions differently.", "doi": "10.1111/jasp.12806", "pmid": "34511637", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "JASP12806"}, {"db": "pmc", "key": "PMC8420191"}], "notes": [], "created": "2021-09-20T06:35:30.177Z", "modified": "2022-11-23T08:54:37.258Z"}, {"entity": "publication", "iuid": "4e9563984492429597bcad2167bf9b30", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4e9563984492429597bcad2167bf9b30.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4e9563984492429597bcad2167bf9b30"}}, "title": "Does the Covid-19 pandemic affect ankle fracture incidence? Moderate decrease in Sweden.", "authors": [{"family": "Rydberg", "given": "Emilia M\u00f6ller", "initials": "EM"}, {"family": "M\u00f6ller", "given": "Michael", "initials": "M"}, {"family": "Ekelund", "given": "Jan", "initials": "J"}, {"family": "Wolf", "given": "Olof", "initials": "O"}, {"family": "Wennergren", "given": "David", "initials": "D"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Acta Orthop", "issn": "1745-3682", "volume": "92", "issue": "4", "pages": "381-384", "issn-l": null}, "abstract": "Background and purpose - While many other countries implemented strict regulations and restrictions for their citizens during the 1st wave of the Covid-19 pandemic, Sweden maintained a more restrained approach. The Swedish Public Health Agency emphasized individual responsibility and pushed for behavioral changes. With strict lockdown a 77% decrease in ankle fracture incidence has been reported. We investigated whether there was a change in the incidence of ankle fractures seen at 7 selected hospitals during the Covid-19 pandemic 2020.Patients and methods - Data on all ankle fractures treated at 7 selected departments during March 15 through June 15, 2020, and for the same period in the preceding 3 years (2017-2019), was retrieved from the Swedish Fracture Register. The number of fractures during the whole period and subsequent 30-day periods were compared between 2020 and 2017-2019, including subgroup analyses of age and sex.Results - The monthly rate of ankle fractures was reduced by 14% in 2020 (139 fractures) compared with 2017-2019 (161 fractures). Women had a 16% decrease and patients aged > 70 years had a 29% decrease. During the 1st 30-day period, a 26% decrease in fractures was seen.Interpretation - During the 1st wave of the Covid-19 pandemic, a moderate decline in the number of ankle fractures was seen. Women and patients aged > 70 years displayed the greatest reduction. The greatest reduction in incidence of fractures was seen during the 1st 30-day period. This indicates greater adherence to government recommendations regarding social distancing in these subgroups and during the 1st month of the pandemic. Changes in ankle fracture incidence may be a measure of lockdown extent.", "doi": "10.1080/17453674.2021.1907517", "pmid": "33821759", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8381968"}], "notes": [], "created": "2021-04-07T10:08:29.763Z", "modified": "2023-01-13T14:44:23.002Z"}, {"entity": "publication", "iuid": "9bdd9b267bc0427a8658fda308767fce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9bdd9b267bc0427a8658fda308767fce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9bdd9b267bc0427a8658fda308767fce"}}, "title": "Diagnostics and management of tuberculosis and COVID-19 in a patient with pneumothorax (clinical case).", "authors": [{"family": "Starshinova", "given": "A", "initials": "A"}, {"family": "Guglielmetti", "given": "L", "initials": "L"}, {"family": "Rzhepishevska", "given": "O", "initials": "O"}, {"family": "Ekaterincheva", "given": "O", "initials": "O"}, {"family": "Zinchenko", "given": "Yu", "initials": "Y"}, {"family": "Kudlay", "given": "D", "initials": "D"}], "type": "case reports", "published": "2021-08-00", "journal": {"title": "J Clin Tuberc Other Mycobact Dis", "issn": "2405-5794", "volume": "24", "pages": "100259", "issn-l": null}, "abstract": "The spread of COVID-19 in countries with high and medium incidence of tuberculosis has led to an increased risk of COVID-19 and tuberculosis co-infection, introducing new diagnostic and therapeutic challenges for the clinician. Hereby we describe a first case where tuberculosis and COVID-19 were diagnosed concomitantly in a Russian patient with pneumothorax. We discuss the challenges associated with the diagnosis and treatment of tuberculosis during the COVID-19 pandemic.", "doi": "10.1016/j.jctube.2021.100259", "pmid": "34235277", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2405-5794(21)00048-6"}, {"db": "pmc", "key": "PMC8245665"}], "notes": [], "created": "2021-08-06T08:23:23.405Z", "modified": "2021-08-06T08:24:22.465Z"}, {"entity": "publication", "iuid": "c47cff1970a64cb7bf6108777ab2b756", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c47cff1970a64cb7bf6108777ab2b756.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c47cff1970a64cb7bf6108777ab2b756"}}, "title": "Determinants for hospitalisations, intensive care unit admission and death among 20,293 reported COVID-19 cases in Portugal, March to April 2020.", "authors": [{"family": "Ricoca Peixoto", "given": "Vasco", "initials": "V"}, {"family": "Vieira", "given": "Andr\u00e9", "initials": "A"}, {"family": "Aguiar", "given": "Pedro", "initials": "P"}, {"family": "Sousa", "given": "Paulo", "initials": "P"}, {"family": "Carvalho", "given": "Carlos", "initials": "C"}, {"family": "Thomas", "given": "Daniel", "initials": "D"}, {"family": "Abrantes", "given": "Alexandre", "initials": "A"}, {"family": "Nunes", "given": "Carla", "initials": "C"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "33", "pages": null}, "abstract": "BackgroundDeterminants of hospitalisation, intensive care unit (ICU) admission and death are still unclear for COVID-19. Few studies have adjusted for confounding for different clinical outcomes including all reported cases within a country.AimWe used routine surveillance data from Portugal to identify risk factors for severe COVID-19 outcomes, and to support risk stratification, public health interventions, and planning of healthcare resources.MethodsWe conducted a retrospective cohort study including 20,293 laboratory-confirmed cases of COVID-19 reported between 1 March and 28 April 2020 through the national epidemiological surveillance system. We calculated absolute risk, relative risk (RR) and adjusted relative risk (aRR) to identify demographic and clinical factors associated with hospitalisation, ICU admission and death using Poisson regressions.ResultsIncreasing age (\u2265 60 years) was the major determinant for all outcomes. Age \u2265 90 years was the strongest determinant of hospital admission (aRR: 6.1), and 70-79 years for ICU (aRR: 10.4). Comorbidities of cardiovascular, immunodeficiency, kidney and lung disease (aRR: 4.3, 2.8, 2.4, 2.0, respectively) had stronger associations with ICU admission, while for death they were kidney, cardiovascular and chronic neurological disease (aRR: 2.9, 2.6, 2.0).ConclusionsOlder age was the strongest risk factor for all severe outcomes. These findings from the early stages of the COVID-19 pandemic support risk-stratified public health measures that should prioritise protecting older people. Epidemiological scenarios and clinical guidelines should consider this, even though under-ascertainment should also be considered.", "doi": "10.2807/1560-7917.ES.2021.26.33.2001059", "pmid": "34414882", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-27T09:44:40.422Z", "modified": "2021-11-18T12:57:57.607Z"}, {"entity": "publication", "iuid": "8912dbd2cef94ff1910c5711bf0b7f83", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8912dbd2cef94ff1910c5711bf0b7f83.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8912dbd2cef94ff1910c5711bf0b7f83"}}, "title": "Comorbidity status of deceased COVID-19 in-patients in Italy.", "authors": [{"family": "Vetrano", "given": "Davide Liborio", "initials": "DL", "orcid": "0000-0002-3099-4830", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0124721bb214413a34c965b6accc64b.json"}}, {"family": "Tazzeo", "given": "Clare", "initials": "C"}, {"family": "Palmieri", "given": "Luigi", "initials": "L"}, {"family": "Marengoni", "given": "Alessandra", "initials": "A"}, {"family": "Zucchelli", "given": "Alberto", "initials": "A"}, {"family": "Lo Noce", "given": "Cinzia", "initials": "C"}, {"family": "Onder", "given": "Graziano", "initials": "G"}, {"family": "Italian National Institute of Health Covid-Mortality Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Aging Clin Exp Res", "issn": "1720-8319", "issn-l": "1594-0667", "volume": "33", "issue": "8", "pages": "2361-2365"}, "abstract": "Most COVID-19-related deaths have occurred in older persons with comorbidities. Specific patterns of comorbidities related to COVID-19 deaths have not been investigated.\n\nA random sample of 6085 individuals in Italy who died in-hospital with confirmed COVID-19 between February and December 2020 were included. Observed to expected (O/E) ratios of disease pairs were computed and logistic regression models were used to determine the association between disease pairs with O/E values \u2265 1.5.\n\nSix pairs of diseases exhibited O/E values \u2265 1.5 and statistically significant higher odds of co-occurrence in the crude and adjusted analyses: (1) ischemic heart disease and atrial fibrillation, (2) atrial fibrillation and heart failure, (3) atrial fibrillation and stroke, (4) heart failure and COPD, (5) stroke and dementia, and (6) type 2 diabetes and obesity.\n\nIn those deceased in-hospital due to COVID-19 in Italy, disease combinations defined by multiple cardio-respiratory, metabolic, and neuropsychiatric diseases occur more frequently than expected. This finding indicates a need to investigate the possible role of these clinical profiles in the chain of events that lead to death in individuals who have contracted SARS-CoV-2.", "doi": "10.1007/s40520-021-01914-y", "pmid": "34169447", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8224257"}, {"db": "pii", "key": "10.1007/s40520-021-01914-y"}], "notes": [], "created": "2021-06-28T18:14:36.919Z", "modified": "2023-06-19T15:29:44.970Z"}, {"entity": "publication", "iuid": "db66a5d743f54eb4b1dd5e5a1d97a38a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db66a5d743f54eb4b1dd5e5a1d97a38a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db66a5d743f54eb4b1dd5e5a1d97a38a"}}, "title": "Antibody responses after a single dose of ChAdOx1 nCoV-19 vaccine in healthcare workers previously infected with SARS-CoV-2.", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f28f2f6ac9648629c2d2de92fe7bb59.json"}}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/305bca9e5c6c423898c272bf06ce2f2a.json"}}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Salomonsson", "given": "Ann-Christin", "initials": "AC"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1345-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a53a433db6f04a458e3d420f0c9995c5.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": "70", "issue": null, "pages": "103523"}, "abstract": "Recent reports demonstrate robust serological responses to a single dose of messenger RNA (mRNA) vaccines in individuals previously infected with SARS-CoV-2. Data on immune responses following a single-dose adenovirus-vectored vaccine expressing the SARS-CoV-2 spike protein (ChAdOx1 nCoV-19) in individuals with previous SARS-CoV-2 infection are however limited, and current guidelines recommend a two-dose regimen regardless of preexisting immunity.\n\nWe compared RBD-specific IgG and RBD-ACE2 blocking antibodies against SARS-CoV-2 wild type and variants of concern following two doses of the mRNA vaccine BNT162b2 in SARS-CoV-2 na\u00efve healthcare workers (n=65) and a single dose of the adenovector vaccine ChAdOx1 nCoV-19 in 82 healthcare workers more than (n=45) and less than (n=37) 11 months post mild SARS-CoV-2 infection at time of vaccination.\n\nThe post-vaccine levels of RBD-specific IgG and neutralizing antibodies against the SARS-CoV-2 wild type and variants of concern including Delta lineage 1.617.2 were similar or higher in participants receiving a single dose of ChAdOx1 nCoV-19 vaccine post SARS-CoV-2 infection (both more than and less than 11 months post infection) compared to SARS-CoV-2 na\u00efve participants who received two doses of BNT162b2 vaccine.\n\nOur data support that a single dose ChAdOx1 nCoV-19 vaccine that is administered up to at least 11 months post SARS-CoV-2 infection serves as an effective immune booster. This provides a possible rationale for a single-dose vaccine regimen.\n\nA full list of funding bodies that contributed to this study can be found in the Acknowledgements section.", "doi": "10.1016/j.ebiom.2021.103523", "pmid": "34391088", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Drug discovery and repurposing of drugs": null, "Research Area: Host cell systems biology and targets": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8357428"}, {"db": "pii", "key": "S2352-3964(21)00316-9"}], "notes": [], "created": "2021-05-17T19:14:38.806Z", "modified": "2023-06-19T14:33:13.824Z"}, {"entity": "publication", "iuid": "88644ac51d8c41fcbf8cf8396c907d1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/88644ac51d8c41fcbf8cf8396c907d1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/88644ac51d8c41fcbf8cf8396c907d1d"}}, "title": "A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic.", "authors": [{"family": "Wang", "given": "Ke", "initials": "K", "orcid": "0000-0002-5776-0815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92a94307dd704b3086b3bc04ccd5dbfc.json"}}, {"family": "Goldenberg", "given": "Amit", "initials": "A"}, {"family": "Dorison", "given": "Charles A", "initials": "CA", "orcid": "0000-0002-7072-2530", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/333f1c9b074c4d38894624278ae79751.json"}}, {"family": "Miller", "given": "Jeremy K", "initials": "JK", "orcid": "0000-0003-4409-7660", "researcher": {"href": 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"https://publications-covid19.scilifelab.se/researcher/d67c255cec3a47b79ddaaf09b6c59cee.json"}}, {"family": "Ebersole", "given": "Charles R", "initials": "CR"}, {"family": "Chartier", "given": "Christopher R", "initials": "CR", "orcid": "0000-0002-4568-4827", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d62a113c9b8447585c9146ebe085e33.json"}}, {"family": "Mallik", "given": "Peter R", "initials": "PR"}, {"family": "Urry", "given": "Heather L", "initials": "HL", "orcid": "0000-0003-4915-1785", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1ef8e659f174f8fa429656c23a05452.json"}}, {"family": "Buchanan", "given": "Erin M", "initials": "EM", "orcid": "0000-0002-9689-4189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5878425d18e4c0cb1fa64b5a63df968.json"}}, {"family": "Coles", "given": "Nicholas A", "initials": "NA", "orcid": "0000-0001-8583-5610", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a0194b331e640dc8548c14eb7e3b2fd.json"}}, {"family": "Primbs", "given": "Maximilian A", "initials": "MA", "orcid": "0000-0002-3398-5569", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96936f42ec994e358255f23d7f969a97.json"}}, {"family": "Basnight-Brown", "given": "Dana M", "initials": "DM", "orcid": "0000-0002-7200-6976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ac1d426131d40eeb088a3ad71fbeb4e.json"}}, {"family": "IJzerman", "given": "Hans", "initials": "H", "orcid": "0000-0002-0990-2276", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0bb878701ae942e19cbb54fa33787a5a.json"}}, {"family": "Forscher", "given": "Patrick S", "initials": "PS", "orcid": "0000-0002-7763-3565", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d5f78c637ff45e6899240ac263367c3.json"}}, {"family": "Moshontz", "given": "Hannah", "initials": "H", "orcid": "0000-0003-4345-3715", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92ab3cbbe34b43abb40476227a7ee357.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Nat Hum Behav", "issn": "2397-3374", "volume": "5", "issue": "8", "pages": "1089-1110", "issn-l": "2397-3374"}, "abstract": "The COVID-19 pandemic has increased negative emotions and decreased positive emotions globally. Left unchecked, these emotional changes might have a wide array of adverse impacts. To reduce negative emotions and increase positive emotions, we tested the effectiveness of reappraisal, an emotion-regulation strategy that modifies how one thinks about a situation. Participants from 87 countries and regions (n = 21,644) were randomly assigned to one of two brief reappraisal interventions (reconstrual or repurposing) or one of two control conditions (active or passive). Results revealed that both reappraisal interventions (vesus both control conditions) consistently reduced negative emotions and increased positive emotions across different measures. Reconstrual and repurposing interventions had similar effects. Importantly, planned exploratory analyses indicated that reappraisal interventions did not reduce intentions to practice preventive health behaviours. The findings demonstrate the viability of creating scalable, low-cost interventions for use around the world. PROTOCOL REGISTRATION: The stage 1 protocol for this Registered Report was accepted in principle on 12 May 2020. The protocol, as accepted by the journal, can be found at https://doi.org/10.6084/m9.figshare.c.4878591.v1.", "doi": "10.1038/s41562-021-01173-x", "pmid": "34341554", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41562-021-01173-x"}, {"db": "URL", "key": "https://osf.io/jeu73/.", "description": "Raw data, processed data and code"}], "notes": [], "created": "2021-08-04T10:08:50.740Z", "modified": "2021-11-18T13:04:43.407Z"}, {"entity": "publication", "iuid": "2636d27430424f9ba9bbc3dcae9d5353", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2636d27430424f9ba9bbc3dcae9d5353.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2636d27430424f9ba9bbc3dcae9d5353"}}, "title": "A health systems resilience research agenda: moving from concept to practice.", "authors": [{"family": "Saulnier", "given": "Dell D", "initials": "DD", "orcid": "0000-0001-7761-0737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d3fc961101845b1ae844339af7495e4.json"}}, {"family": "Blanchet", "given": "Karl", "initials": "K", "orcid": "0000-0003-0498-8020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aad004843f3f44c8b011feedf86831e1.json"}}, {"family": "Canila", "given": "Carmelita", "initials": "C"}, {"family": "Cobos Mu\u00f1oz", "given": "Daniel", "initials": "D"}, {"family": "Dal Zennaro", "given": "Livia", "initials": "L"}, {"family": "de Savigny", "given": "Don", "initials": "D"}, {"family": "Durski", "given": "Kara N", "initials": "KN", "orcid": "0000-0003-1456-626X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c3c8647d0fb46f3bc270457481eccdb.json"}}, {"family": "Garcia", "given": "Fernando", "initials": "F"}, {"family": "Grimm", "given": "Pauline Yongeun", "initials": "PY"}, {"family": "Kwamie", "given": "Aku", "initials": "A"}, {"family": "Maceira", "given": "Daniel", "initials": "D"}, {"family": "Marten", "given": "Robert", "initials": "R", "orcid": "0000-0002-2416-2309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5304e89b214846d0a6f2097df8eb1439.json"}}, {"family": "Peytremann-Bridevaux", "given": "Isabelle", "initials": "I"}, {"family": "Poroes", "given": "Camille", "initials": "C"}, {"family": "Ridde", "given": "Valery", "initials": "V", "orcid": "0000-0001-9299-8266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e62a45cb15a4d66966e72c363547b2d.json"}}, {"family": "Seematter", "given": "Laurence", "initials": "L"}, {"family": "Stern", "given": "Barbara", "initials": "B"}, {"family": "Suarez", "given": "Patricia", "initials": "P"}, {"family": "Teddy", "given": "Gina", "initials": "G"}, {"family": "Wernli", "given": "Didier", "initials": "D", "orcid": "0000-0002-1751-1961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d61d17a45a24592aa9bf5ebea861503.json"}}, {"family": "Wyss", "given": "Kaspar", "initials": "K"}, {"family": "Tediosi", "given": "Fabrizio", "initials": "F", "orcid": "0000-0001-8671-9400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9884188f9c04312b05212ade939818d.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "8", "issn-l": "2059-7908"}, "abstract": "Health system resilience, known as the ability for health systems to absorb, adapt or transform to maintain essential functions when stressed or shocked, has quickly gained popularity following shocks like COVID-19. The concept is relatively new in health policy and systems research and the existing research remains mostly theoretical. Research to date has viewed resilience as an outcome that can be measured through performance outcomes, as an ability of complex adaptive systems that is derived from dynamic behaviour and interactions, or as both. However, there is little congruence on the theory and the existing frameworks have not been widely used, which as diluted the research applications for health system resilience. A global group of health system researchers were convened in March 2021 to discuss and identify priorities for health system resilience research and implementation based on lessons from COVID-19 and other health emergencies. Five research priority areas were identified: (1) measuring and managing systems dynamic performance, (2) the linkages between societal resilience and health system resilience, (3) the effect of governance on the capacity for resilience, (4) creating legitimacy and (5) the influence of the private sector on health system resilience. A key to filling these research gaps will be longitudinal and comparative case studies that use cocreation and coproduction approaches that go beyond researchers to include policy-makers, practitioners and the public.", "doi": "10.1136/bmjgh-2021-006779", "pmid": "34353820", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-006779"}], "notes": [], "created": "2021-08-11T14:41:14.804Z", "modified": "2021-08-11T14:41:14.962Z"}, {"entity": "publication", "iuid": "21a1ff9833a248a497680dccbef0cb6b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/21a1ff9833a248a497680dccbef0cb6b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/21a1ff9833a248a497680dccbef0cb6b"}}, "title": "Investigating tinnitus subgroups based on hearing-related difficulties.", "authors": [{"family": "Beukes", "given": "Eldr\u00e9 W", "initials": "EW", "orcid": "0000-0002-9434-9160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b5ab9ec02014cd9bd58a095f8175dd2.json"}}, {"family": "Baguley", "given": "David M", "initials": "DM"}, {"family": "Manchaiah", "given": "Vinaya", "initials": "V"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Allen", "given": "Peter M", "initials": "PM"}, {"family": "Kaldo", "given": "Viktor", "initials": "V"}, {"family": "Jacquemin", "given": "Laure", "initials": "L"}, {"family": "Lourenco", "given": "Matheus P C G", "initials": "MPCG"}, {"family": "Onozuka", "given": "Joy", "initials": "J"}, {"family": "Stockdale", "given": "David", "initials": "D"}, {"family": "Maidment", "given": "David W", "initials": "DW"}], "type": "journal article", "published": "2021-07-31", "journal": {"title": "Int J Clin Pract", "issn": "1742-1241", "pages": "e14684", "issn-l": null}, "abstract": "Meaningfully grouping individuals with tinnitus who share the common characteristics (i.e., subgrouping, phenotyping) may help tailor interventions to certain tinnitus subgroups and hence reduce outcome variability. The purpose of this study was to test if the presence of tinnitus subgroups are discernible based on hearing-related comorbidities, and to identify predictors of tinnitus severity for each subgroup identified.\n\nAn exploratory cross-sectional study was used. The study was nested within an online survey distributed worldwide to investigate tinnitus experiences during the COVID-19 pandemic. The main outcome measure was the tinnitus Handicap Inventory- Screening Version RESULTS: From the 3400 respondents, 2,980 were eligible adults with tinnitus with an average age of 58 years (SD= 14.7) with 50% (n= 1,457) being female. A three-cluster solution identified distinct subgroups, namely, those with tinnitus but no hearing loss (n = 1,306; 44%), those presenting with tinnitus and hyperacusis and/or misophonia (n = 795; 27%), and those with tinnitus and hearing loss (n = 879; 29%). Those with tinnitus and hyperacusis reported the highest tinnitus severity (M= 20.3; SD= 10.5) and those with tinnitus and no hearing loss had the lowest tinnitus severity (M= 15.7; SD= 10.4). Younger age and the presence of mental health problems predicted greater tinnitus severity for all groups (\u03b2\u2264 -.1, p\u2264 .016).\n\nFurther exploration of these potential subtypes are needed in both further research and clinical practice by initially triaging tinnitus patients prior to their clinical appointments based on the presence of hearing-related comorbidities. Unique management pathways and interventions could be tailored for each tinnitus subgroup.", "doi": "10.1111/ijcp.14684", "pmid": "34331723", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-04T17:02:52.619Z", "modified": "2021-08-04T17:02:52.661Z"}, {"entity": "publication", "iuid": "1dcc9c1c68f9403da3ab22f2eb3e8cb3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1dcc9c1c68f9403da3ab22f2eb3e8cb3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1dcc9c1c68f9403da3ab22f2eb3e8cb3"}}, "title": "High expression of neutrophil and monocyte CD64 with simultaneous lack of upregulation of adhesion receptors CD11b, CD162, CD15, CD65 on neutrophils in severe COVID-19.", "authors": [{"family": "Karawajczyk", "given": "Malgorzata", "initials": "M", "orcid": "0000-0001-8192-0076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e42747d6ce4241f9aaa79c597475dc62.json"}}, {"family": "Douhan H\u00e5kansson", "given": "Lena", "initials": "L"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Pauksens", "given": "Karlis", "initials": "K"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Larsson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-07-31", "journal": {"title": "Ther Adv Infect Dis", "issn": "2049-9361", "issn-l": null, "volume": "8", "issue": null, "pages": "20499361211034065"}, "abstract": "The pronounced neutrophilia observed in patients with coronavirus disease 2019 (COVID-19) infections suggests a role for these leukocytes in the pathology of the disease. Monocyte and neutrophil expression of CD64 and CD11b have been reported as early biomarkers to detect infections. The aim of this study was to study the expression of receptors for IgG (CD64) and adhesion molecules (CD11b, CD15s, CD65, CD162, CD66b) on neutrophils and monocytes in patients with severe COVID-19 after admission to an intensive care unit (ICU).\n\nThe expression of receptors was analyzed using flow cytometry. EDTA blood from 23 patients with confirmed COVID-19 infection was sampled within 48 h of admission to the ICU. Leukocytes were labeled with antibodies to CD11b, CD15s, CD65s, CD162, CD64, and CD66b. Expression of receptors was reported as mean fluorescence intensity (MFI) or the percentage of cells expressing receptors.\n\nResults are presented as comparison of COVID-19 patients with the healthy group and the receptor expression as MFI. Neutrophil receptors CD64 (2.5 versus 0.5) and CD66b (44.5 versus 34) were increased and CD15 decreased (21.6 versus 28.3) when CD65 (6.6 versus 4.4), CD162 (21.3 versus 21.1) and CD11b (10.5 versus 12) were in the same range. Monocytes receptors CD64 (30.5 versus 16.6), CD11b (18.7 versus 9.8), and CD162 (38.6 versus 36.5) were increased and CD15 decreased (10.3 versus 17.9); CD65 were in the same range (2.3 versus 1.96).\n\nMonocytes and neutrophils are activated during severe COVID-19 infection as shown by strong upregulation of CD64. High monocyte and neutrophil CD64 can be an indicator of a severe form of COVID19. The adhesion molecules (CD11b, CD162, CD65, and CD15) are not upregulated on otherwise activated neutrophils, which might lead to relative impairment of tissue migration. Low adhesion profile of neutrophils suggests immune dysfunction of neutrophils. Monocytes maintain upregulation of some adhesion molecules (CD11b, CD162) suggesting the persistence of an increased ability to migrate into tissues, even during a severe stage of COVID-19. Future research should focus on CD64 and CD11b kinetics in the context of prognosis.", "doi": "10.1177/20499361211034065", "pmid": "34377464", "labels": {"Funder: VR": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pmc", "key": "PMC8326822"}, {"db": "pii", "key": "10.1177_20499361211034065"}], "notes": [], "created": "2021-08-12T17:04:26.909Z", "modified": "2023-06-19T14:59:17.671Z"}, {"entity": "publication", "iuid": "c588fa750a8444f6858a06bdaafe89cd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c588fa750a8444f6858a06bdaafe89cd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c588fa750a8444f6858a06bdaafe89cd"}}, "title": "Anti-Viral and Immunomodulatory Properties of Propolis: Chemical Diversity, Pharmacological Properties, Preclinical and Clinical Applications, and In Silico Potential against SARS-CoV-2.", "authors": [{"family": "Yosri", "given": "Nermeen", "initials": "N", "orcid": "0000-0002-5043-9690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4179b7f496234c44bfb86f42d793209f.json"}}, {"family": "Abd El-Wahed", "given": "Aida A", "initials": "AA", "orcid": "0000-0002-2200-3507", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c6fbed70bba4ea79707d30822d774bd.json"}}, {"family": "Ghonaim", "given": "Reem", "initials": "R"}, {"family": "Khattab", "given": "Omar M", "initials": "OM"}, {"family": "Sabry", "given": "Aya", "initials": "A"}, {"family": "Ibrahim", "given": "Mahmoud A A", "initials": "MAA", "orcid": "0000-0003-4819-2040", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/552195f5616e456b82fd45359b56f9c7.json"}}, {"family": "Moustafa", "given": "Mahmoud F", "initials": "MF"}, {"family": "Guo", "given": "Zhiming", "initials": "Z", "orcid": "0000-0001-6416-7457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3be657eca2a84ef48613cd71b9a43222.json"}}, {"family": "Zou", "given": "Xiaobo", "initials": "X"}, {"family": "Algethami", "given": "Ahmed F M", "initials": "AFM"}, {"family": "Masry", "given": "Saad H D", "initials": "SHD"}, {"family": "AlAjmi", "given": "Mohamed F", "initials": "MF"}, {"family": "Afifi", "given": "Hanan S", "initials": "HS"}, {"family": "Khalifa", "given": "Shaden A M", "initials": "SAM"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}], "type": "journal article", "published": "2021-07-31", "journal": {"title": "Foods", "issn": "2304-8158", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "Propolis, a resin produced by honeybees, has long been used as a dietary supplement and folk remedy, and more recent preclinical investigations have demonstrated a large spectrum of potential therapeutic bioactivities, including antioxidant, antibacterial, anti-inflammatory, neuroprotective, immunomodulatory, anticancer, and antiviral properties. As an antiviral agent, propolis and various constituents have shown promising preclinical efficacy against adenoviruses, influenza viruses, respiratory tract viruses, herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), human immunodeficiency virus (HIV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Over 300 chemical components have been identified in propolis, including terpenes, flavonoids, and phenolic acids, with the specific constituent profile varying widely according to geographic origin and regional flora. Propolis and its constituents have demonstrated potential efficacy against SARS-CoV-2 by modulating multiple pathogenic and antiviral pathways. Molecular docking studies have demonstrated high binding affinities of propolis derivatives to multiple SARS-CoV-2 proteins, including 3C-like protease (3CLpro), papain-like protease (PLpro), RNA-dependent RNA polymerase (RdRp), the receptor-binding domain (RBD) of the spike protein (S-protein), and helicase (NSP13), as well as to the viral target angiotensin-converting enzyme 2 (ACE2). Among these compounds, retusapurpurin A has shown high affinity to 3CLpro (\u0394G = -9.4 kcal/mol), RdRp (-7.5), RBD (-7.2), NSP13 (-9.4), and ACE2 (-10.4) and potent inhibition of viral entry by forming hydrogen bonds with amino acid residues within viral and human target proteins. In addition, propolis-derived baccharin demonstrated even higher binding affinity towards PLpro (-8.2 kcal/mol). Measures of drug-likeness parameters, including metabolism, distribution, absorption, excretion, and toxicity (ADMET) characteristics, also support the potential of propolis as an effective agent to combat COVID-19.", "doi": "10.3390/foods10081776", "pmid": "34441553", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "foods10081776"}, {"db": "pmc", "key": "PMC8391193"}], "notes": [], "created": "2021-09-01T07:15:52.044Z", "modified": "2021-09-01T07:15:52.145Z"}, {"entity": "publication", "iuid": "199aec09cf01468a9111c3c31b8302eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/199aec09cf01468a9111c3c31b8302eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/199aec09cf01468a9111c3c31b8302eb"}}, "title": "Swedish Covid-19 Investigation for Future Insights - A Population Epidemiology Approach Using Register Linkage (SCIFI-PEARL).", "authors": [{"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Franz\u00e9n", "given": "Stefan", "initials": "S"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Vanfleteren", "given": "Lowie", "initials": "L", "orcid": "0000-0002-4387-4096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bb5d1f761ef48c4837ed4f984717f0e.json"}}, {"family": "Hammar", "given": "Niklas", "initials": "N"}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2c4588f000c470abf08f2e40852b6d1.json"}}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Bj\u00f6rck", "given": "Staffan", "initials": "S"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}], "type": "journal article", "published": "2021-07-30", "journal": {"title": "CLEP", "issn": "1179-1349", "issn-l": null, "volume": "13", "issue": null, "pages": "649-659"}, "abstract": "In response to the Covid-19 pandemic, we designed and initiated a nationwide linked multi-register, regularly updated, observational study for timely response to urgent scientific questions.\r\n\r\nTo describe the SCIFI-PEARL (Swedish Covid-19 Investigation for Future Insights - a Population Epidemiology Approach using Register Linkage) linked database encompassing essentially all known diagnosed Swedish Covid-19 patients plus a large general population comparison cohort and outline its utility in the current and future phases of the pandemic.\r\n\r\nIndividuals with Covid-19 from the entire country are identified on a regularly updated basis, from different sources: all individuals from SmiNet, the national database of notifiable diseases, with positive SARS-CoV-2 polymerase chain reaction (PCR) test results; patients identified in the healthcare system by condition (ICD-10) or procedure codes in the National Patient Register or Cause-of-Death Register; patients identified through several disease-specific national quality registers (NQRs); and in two regions additionally patients identified in primary care. A comparison population was obtained by stratified random sampling from Swedish national population registers. Data from all these registers plus the National Prescribed Drug Register, the Cancer Register, national sociodemographic registers, some additional NQRs, the National Vaccination Register, and further data sources, are then linked to all study subjects (Covid-19 cases and population cohort). New cases in the study population and all data for all subjects are updated every few months, as required.\r\n\r\nThe SCIFI-PEARL study cohort captures Swedish residents with Covid-19 on an ongoing basis, includes a representative general population comparison cohort, and links to a broad range of national and regional healthcare data for a comprehensive longitudinal view of the Covid-19 pandemic. By combining high-quality national registers with short time delay and continuous repeated linkage and updating, the project brings timely and internationally relevant data for epidemiological research on SARS-CoV-2. Our efforts provide an example and important learnings for similar efforts internationally in the future.", "doi": "10.2147/CLEP.S312742", "pmid": "34354377", "labels": {"Research Area: Vaccine": null, "Category: Public Health": null, "Type: Journal article": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "312742"}, {"db": "pmc", "key": "PMC8331198"}], "notes": [], "created": "2021-08-12T12:22:04.801Z", "modified": "2021-12-06T12:29:00.905Z"}, {"entity": "publication", "iuid": "89bcd628edf945e68aed0254ce19aa95", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/89bcd628edf945e68aed0254ce19aa95.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/89bcd628edf945e68aed0254ce19aa95"}}, "title": "Impact of the COVID-19 pandemic on nuclear medicine departments in Europe.", "authors": [{"family": "Moreira", "given": "Ana Paula", "initials": "AP", "orcid": "0000-0001-6873-6039", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5f3afab19af4ba3a538c1a387b69642.json"}}, {"family": "Jamar", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Ozcan", "given": "Zehra", "initials": "Z"}, {"family": "Piciu", "given": "Doina", "initials": "D"}, {"family": "Als", "given": "Claudine", "initials": "C"}, {"family": "Franceschi", "given": "Maja", "initials": "M"}, {"family": "Tr\u00e4g\u00e5rdh", "given": "Elin", "initials": "E"}, {"family": "Zagar", "given": "Ivana", "initials": "I"}, {"family": "Sowa-Staszczak", "given": "Anna", "initials": "A"}, {"family": "Cachin", "given": "Florent", "initials": "F"}, {"family": "Bennink", "given": "Roel", "initials": "R"}, {"family": "Forrer", "given": "Flavio", "initials": "F"}, {"family": "Adamsen", "given": "Tom Christian", "initials": "TC"}, {"family": "Fotopolous", "given": "Andreas", "initials": "A"}, {"family": "Kalnina", "given": "Marika", "initials": "M"}, {"family": "Jensen", "given": "Lars Thorbj\u00f8rn", "initials": "LT"}, {"family": "Mussalo", "given": "Hanna", "initials": "H"}, {"family": "Simanek", "given": "Milan", "initials": "M"}, {"family": "Garcia-Ca\u00f1amaque", "given": "Lina", "initials": "L"}, {"family": "Nazarenko", "given": "Sergei", "initials": "S"}, {"family": "Mihailovic", "given": "Jasna", "initials": "J"}, {"family": "Bar-Sever", "given": "Zvi", "initials": "Z"}, {"family": "O'Connell", "given": "Martin", "initials": "M"}, {"family": "Miladinova", "given": "Daniela", "initials": "D"}, {"family": "Graham", "given": "Richard", "initials": "R"}, {"family": "Giubbini", "given": "Raffaele", "initials": "R"}, {"family": "Kalisk\u00e1", "given": "Lucia", "initials": "L"}, {"family": "Rozi\u0107", "given": "Damir", "initials": "D"}, {"family": "Krause", "given": "Bernd J", "initials": "BJ"}, {"family": "Gallowitsch", "given": "Hans-J\u00fcrgen", "initials": "HJ"}, {"family": "Gy\u00f6rke", "given": "Tam\u00e1s", "initials": "T"}, {"family": "Sediene", "given": "Severina", "initials": "S"}, {"family": "Rumyantsev", "given": "Pavel", "initials": "P"}, {"family": "Wadsak", "given": "Wolfgang", "initials": "W"}, {"family": "Kunikowska", "given": "Jolanta", "initials": "J"}], "type": "editorial", "published": "2021-07-30", "journal": {"title": "Eur J Nucl Med Mol Imaging", "issn": "1619-7089", "issn-l": null}, "abstract": null, "doi": "10.1007/s00259-021-05484-z", "pmid": "34328532", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00259-021-05484-z"}, {"db": "pmc", "key": "PMC8322112"}], "notes": [], "created": "2021-08-04T17:03:29.051Z", "modified": "2021-08-04T17:03:29.091Z"}, {"entity": "publication", "iuid": "95872c856b0a43b89e3f3a8ebeb8a3f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95872c856b0a43b89e3f3a8ebeb8a3f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95872c856b0a43b89e3f3a8ebeb8a3f4"}}, "title": "Antimicrobial stewardship in the ICU in COVID times: the known unknowns.", "authors": [{"family": "Schouten", "given": "Jeroen", "initials": "J"}, {"family": "De Waele", "given": "Jan", "initials": "J"}, {"family": "Lanckohr", "given": "Christian", "initials": "C"}, {"family": "Koulenti", "given": "Despoina", "initials": "D"}, {"family": "Haddad", "given": "Nisrine", "initials": "N"}, {"family": "Rizk", "given": "Nesrine", "initials": "N"}, {"family": "Sj\u00f6vall", "given": "Fredrik", "initials": "F"}, {"family": "Kanj", "given": "Souha S", "initials": "SS"}], "type": "journal article", "published": "2021-07-30", "journal": {"title": "Int J Antimicrob Agents", "issn": "1872-7913", "issn-l": null, "volume": null, "issue": null, "pages": "106409"}, "abstract": "Since the start of the COVID-19 pandemic, there has been concern about the concomitant rise of antimicrobial resistance (AMR). While bacterial co-infections seem rare in COVID-19 patients admitted to hospital wards and ICUs, an increase in empirical antibiotic use has been described. In the ICU setting, where antibiotics are already abundantly -and often inappropriately- prescribed, the need for an ICU specific Antimicrobial Stewardship Program (ASP) is widely advocated. Apart from essentially warning against the use of antibacterial drugs for the treatment of a viral infection, other aspects of ICU antimicrobial stewardship need to be considered in view of the clinical course and characteristics of COVID-19. First, the distinction between infectious and non-infectious (inflammatory) causes of respiratory deterioration during ICU stay is difficult and the much-debated relevance of fungal and viral co-infections adds to the complexity of empirical antimicrobial prescribin. Biomarkers such as PCT for the decision to start antibacterial therapy for ICU nosocomial infections seem to be more promising in COVID-19 than in non-COVID-19 patients. In COVID-19 patients CMV reactivation is an important factor to consider when assessing patients infected with SARS-CoV-2 as it may have a role in modulating patient immune response. The diagnosis of COVID-19 associated Invasive Aspergillosis (CAPA) is challenging because of the lack of sensitivity and specificity of the available tests. Further, altered PK/PD properties need to be taken into account when prescribing antimicrobial therapy. Future research should now further explore the \"known unknowns\", ideally with robust prospective study designs.", "doi": "10.1016/j.ijantimicag.2021.106409", "pmid": "34339777", "labels": {"Type: Review": null, "Category: Public Health": null, "Category: Rehabilitation": null}, "xrefs": [{"db": "pii", "key": "S0924-8579(21)00181-3"}], "notes": [], "created": "2021-08-04T10:11:22.551Z", "modified": "2021-11-18T12:48:00.214Z"}, {"entity": "publication", "iuid": "448436ec26c24e71bc517a9bce6d8e45", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/448436ec26c24e71bc517a9bce6d8e45.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/448436ec26c24e71bc517a9bce6d8e45"}}, "title": "A look into the future of the COVID-19 pandemic in Europe: an expert consultation.", "authors": [{"family": "Iftekhar", "given": "Emil Nafis", "initials": "EN"}, {"family": "Priesemann", "given": "Viola", "initials": "V"}, {"family": "Balling", "given": "Rudi", "initials": "R"}, {"family": "Bauer", "given": "Simon", "initials": "S"}, {"family": "Beutels", "given": "Philippe", "initials": "P"}, {"family": "Calero Valdez", "given": "Andr\u00e9", "initials": "A"}, {"family": "Cuschieri", "given": "Sarah", "initials": "S"}, {"family": "Czypionka", "given": "Thomas", "initials": "T"}, {"family": "Dumpis", "given": "Uga", "initials": "U"}, {"family": "Glaab", "given": "Enrico", "initials": "E"}, {"family": "Grill", "given": "Eva", "initials": "E"}, {"family": "Hanson", "given": "Claudia", "initials": "C"}, {"family": "Hotulainen", "given": "Pirta", "initials": "P"}, {"family": "Klimek", "given": "Peter", "initials": "P"}, {"family": "Kretzschmar", "given": "Mirjam", "initials": "M"}, {"family": "Kr\u00fcger", "given": "Tyll", "initials": "T"}, {"family": "Krutzinna", "given": "Jenny", "initials": "J"}, {"family": "Low", "given": "Nicola", "initials": "N"}, {"family": "Machado", "given": "Helena", "initials": "H"}, {"family": "Martins", "given": "Carlos", "initials": "C"}, {"family": "McKee", "given": "Martin", "initials": "M"}, {"family": "Mohr", "given": "Sebastian Bernd", "initials": "SB"}, {"family": "Nassehi", "given": "Armin", "initials": "A"}, {"family": "Perc", "given": "Matja\u017e", "initials": "M"}, {"family": "Petelos", "given": "Elena", "initials": "E"}, {"family": "Pickersgill", "given": "Martyn", "initials": "M"}, {"family": "Prainsack", "given": "Barbara", "initials": "B"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}, {"family": "Schernhammer", "given": "Eva", "initials": "E"}, {"family": "Staines", "given": "Anthony", "initials": "A"}, {"family": "Szczurek", "given": "Ewa", "initials": "E"}, {"family": "Tsiodras", "given": "Sotirios", "initials": "S"}, {"family": "Van Gucht", "given": "Steven", "initials": "S"}, {"family": "Willeit", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2021-07-30", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "pages": "100185", "issn-l": null}, "abstract": "How will the coronavirus disease 2019 (COVID-19) pandemic develop in the coming months and years? Based on an expert survey, we examine key aspects that are likely to influence the COVID-19 pandemic in Europe. The challenges and developments will strongly depend on the progress of national and global vaccination programs, the emergence and spread of variants of concern (VOCs), and public responses to non-pharmaceutical interventions (NPIs). In the short term, many people remain unvaccinated, VOCs continue to emerge and spread, and mobility and population mixing are expected to increase. Therefore, lifting restrictions too much and too early risk another damaging wave. This challenge remains despite the reduced opportunities for transmission given vaccination progress and reduced indoor mixing in summer 2021. In autumn 2021, increased indoor activity might accelerate the spread again, whilst a necessary reintroduction of NPIs might be too slow. The incidence may strongly rise again, possibly filling intensive care units, if vaccination levels are not high enough. A moderate, adaptive level of NPIs will thus remain necessary. These epidemiological aspects combined with economic, social, and health-related consequences provide a more holistic perspective on the future of the COVID-19 pandemic.", "doi": "10.1016/j.lanepe.2021.100185", "pmid": "34345876", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00162-9"}, {"db": "pmc", "key": "PMC8321710"}], "notes": [], "created": "2021-08-06T09:46:00.472Z", "modified": "2021-08-06T09:46:00.483Z"}, {"entity": "publication", "iuid": "7864977a8d4f41e0adbbdf3e5152c4cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7864977a8d4f41e0adbbdf3e5152c4cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7864977a8d4f41e0adbbdf3e5152c4cf"}}, "title": "Understanding and Responding to the Impact of COVID-19 on Paediatric Gastroenterology Training & Practice of Young ESPGHAN Members.", "authors": [{"family": "Ni\u0163\u0103", "given": "Andreia F", "initials": "AF"}, {"family": "Tsita", "given": "Despina", "initials": "D"}, {"family": "Grima", "given": "Anne-Marie", "initials": "AM"}, {"family": "Cameron", "given": "Fiona", "initials": "F"}, {"family": "Rock", "given": "Nathalie M", "initials": "NM"}, {"family": "Tapsas", "given": "Dimitrios", "initials": "D"}], "type": "journal article", "published": "2021-07-29", "journal": {"title": "J Pediatr Gastroenterol Nutr", "issn": "1536-4801", "issn-l": null}, "abstract": "Limited data exist about the impact of the COVID-19 pandemic on the training and clinical practice of young doctors. The aim of this study was to evaluate the impact on paediatric gastroenterologists in training posts during the first wave of European COVID pandemic.\n\nAll Young ESPGHAN (YE) members received a multiple-choice questionnaire concerning the impact (if any) on their clinical practice, mental health, quality of care provided and fellowship/training experience. The survey was conducted between May 22nd, 2020 and June 10th, 2020.\n\nOf the 144 responders (40% of YE members), 85% (n = 123) reported an impact of COVID-19. 96% reported an impact on their clinical practice, including more virtual patient consultation (n = 91), underutilization of ambulatory care (n = 113) and reduced or lack of planned admissions (n = 75). Endoscopy restrictions to semi-urgent or emergency cases were reported in 82 and lack of medical equipment/drugs (n = 47) were also reported.Reported adverse mental health issues included poor concentration, increased stress levels, an impact on family life in 62% and a reduced quality of care in 45%; this was more often reported in doctors from Southern Europe (54%) than in those from other geographical areas.77% reported an impact on the content of their fellowship, including lack of participation in national/international meetings, withdrawn research time and limited mentoring.\n\nThe impact of the Covid-19 pandemic has been shown to affect the clinical practice, training and mental health of YE members. Adaptations of training programmes and targeted strategies to improve the clinical practice of young practitioners are needed and proposed in this manuscript.", "doi": "10.1097/MPG.0000000000003239", "pmid": "34269327", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00005176-900000000-95598"}], "notes": [], "created": "2021-08-06T07:16:08.125Z", "modified": "2021-08-06T07:16:08.151Z"}, {"entity": "publication", "iuid": "873495dc287a4506b7d1aad39e7087eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/873495dc287a4506b7d1aad39e7087eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/873495dc287a4506b7d1aad39e7087eb"}}, "title": "Topological network based drug repurposing for coronavirus 2019.", "authors": [{"family": "Habibi", "given": "Mahnaz", "initials": "M", "orcid": "0000-0002-8969-2706", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d44ce728e5d5412e8720941daae54a51.json"}}, {"family": "Taheri", "given": "Golnaz", "initials": "G"}], "type": "journal article", "published": "2021-07-29", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "7", "pages": "e0255270", "issn-l": "1932-6203"}, "abstract": "The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has become the current health concern and threat to the entire world. Thus, the world needs the fast recognition of appropriate drugs to restrict the spread of this disease. The global effort started to identify the best drug compounds to treat COVID-19, but going through a series of clinical trials and our lack of information about the details of the virus's performance has slowed down the time to reach this goal. In this work, we try to select the subset of human proteins as candidate sets that can bind to approved drugs. Our method is based on the information on human-virus protein interaction and their effect on the biological processes of the host cells. We also define some informative topological and statistical features for proteins in the protein-protein interaction network. We evaluate our selected sets with two groups of drugs. The first group contains the experimental unapproved treatments for COVID-19, and we show that from 17 drugs in this group, 15 drugs are approved by our selected sets. The second group contains the external clinical trials for COVID-19, and we show that 85% of drugs in this group, target at least one protein of our selected sets. We also study COVID-19 associated protein sets and identify proteins that are essential to disease pathology. For this analysis, we use DAVID tools to show and compare disease-associated genes that are contributed between the COVID-19 comorbidities. Our results for shared genes show significant enrichment for cardiovascular-related, hypertension, diabetes type 2, kidney-related and lung-related diseases. In the last part of this work, we recommend 56 potential effective drugs for further research and investigation for COVID-19 treatment. Materials and implementations are available at: https://github.com/MahnazHabibi/Drug-repurposing.", "doi": "10.1371/journal.pone.0255270", "pmid": "34324563", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-13445"}, {"db": "pmc", "key": "PMC8320924"}], "notes": [], "created": "2021-08-04T17:08:35.085Z", "modified": "2021-08-04T17:08:51.831Z"}, {"entity": "publication", "iuid": "d31bb5c7c6454cc9b62516cf7715a905", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d31bb5c7c6454cc9b62516cf7715a905.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d31bb5c7c6454cc9b62516cf7715a905"}}, "title": "JAK Inhibitors \u2014 More Than Just Glucocorticoids", "authors": [{"family": "Stebbing", "given": "Justin", "initials": "J", "orcid": "0000-0002-1117-6947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/556a75be47ab4c48922a55999648d4e3.json"}}, {"family": "Lauschke", "given": "Volker M", "initials": "VM"}], "type": "journal-article", "published": "2021-07-29", "journal": {"title": "N Engl J Med", "issn": "1533-4406", "volume": "385", "issue": "5", "pages": "463-465", "issn-l": null}, "abstract": null, "doi": "10.1056/nejme2108667", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2021-08-24T12:51:20.585Z", "modified": "2021-08-24T12:51:20.621Z"}, {"entity": "publication", "iuid": "771c423765b6417f97e55e79bf243e7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/771c423765b6417f97e55e79bf243e7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/771c423765b6417f97e55e79bf243e7e"}}, "title": "Impact of SARS-CoV-2 on training and mental well-being of surgical gynecological oncology trainees.", "authors": [{"family": "Gaba", "given": "Faiza", "initials": "F", "orcid": "0000-0003-4081-6883", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b6c7f32259c64092ba285fa71706aab6.json"}}, {"family": "Blyuss", "given": "Oleg", "initials": "O"}, {"family": "Rodriguez", "given": "Isabel", "initials": "I"}, {"family": "Dilley", "given": "James", "initials": "J"}, {"family": "Wan", "given": "Yee-Loi Louise", "initials": "YL"}, {"family": "Saiz", "given": "Allison", "initials": "A"}, {"family": "Razumova", "given": "Zoia", "initials": "Z", "orcid": "0000-0001-6598-0896", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f9dd79d57f44a0ab455974d84356528.json"}}, {"family": "Zalewski", "given": "Kamil", "initials": "K"}, {"family": "Nikolova", "given": "Tanja", "initials": "T"}, {"family": "Selcuk", "given": "Ilker", "initials": "I"}, {"family": "Bizzarri", "given": "Nicol\u00f2", "initials": "N", "orcid": "0000-0002-1727-904X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e74a49b3221461d87f46384492b5b7f.json"}}, {"family": "Theofanakis", "given": "Charalampos", "initials": "C"}, {"family": "Lanner", "given": "Maximilian", "initials": "M"}, {"family": "Pletnev", "given": "Andrei", "initials": "A"}, {"family": "Gurumurthy", "given": "Mahalakshmi", "initials": "M"}, {"family": "Manchanda", "given": "Ranjit", "initials": "R", "orcid": "0000-0003-3381-5057", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91c3585da7d84dc2b7a0788dbfdc78e2.json"}}], "type": "journal article", "published": "2021-07-29", "journal": {"title": "Int J Gynecol Cancer", "issn": "1525-1438", "issn-l": null}, "abstract": "The SARS-CoV-2 global pandemic has caused a crisis disrupting health systems worldwide. While efforts are being made to determine the extent of the disruption, the impact on gynecological oncology trainees/training has not been explored. We conducted an international survey of the impact of SARS-CoV-2 on clinical practice, medical education, and mental well-being of surgical gynecological oncology trainees.\n\nIn our cross-sectional study, a customized web-based survey was circulated to surgical gynecological oncology trainees from national/international organizations from May to November 2020. Validated questionnaires assessed mental well-being. The Wilcoxon rank-sum test and Fisher's exact test were used to analyse differences in means and proportions. Multiple linear regression was used to evaluate the effect of variables on psychological/mental well-being outcomes. Outcomes included clinical practice, medical education, anxiety and depression, distress, and mental well-being.\n\nA total of 127 trainees from 34 countries responded. Of these, 52% (66/127) were from countries with national training programs (UK/USA/Netherlands/Canada/Australia) and 48% (61/127) from countries with no national training programs. Altogether, 28% (35/125) had suspected/confirmed COVID-19, 28% (35/125) experienced a fall in household income, 20% (18/90) were self-isolated from households, 45% (57/126) had to re-use personal protective equipment, and 22% (28/126) purchased their own. In total, 32.3% (41/127) of trainees (16.6% (11/66) from countries with a national training program vs 49.1% (30/61) from countries with no national training program, p=0.02) perceived they would require additional time to complete their training fellowship. The additional training time anticipated did not differ between trainees from countries with or without national training programs (p=0.11) or trainees at the beginning or end of their fellowship (p=0.12). Surgical exposure was reduced for 50% of trainees. Departmental teaching continued throughout the pandemic for 69% (87/126) of trainees, although at reduced frequency for 16.1% (14/87), and virtually for 88.5% (77/87). Trainees reporting adequate pastoral support (defined as allocation of a dedicated mentor/access to occupational health support services) had better mental well-being with lower levels of anxiety/depression (p=0.02) and distress (p<0.001). Trainees from countries with a national training program experienced higher levels of distress (p=0.01). Mean (SD) pre-pandemic mental well-being scores were significantly higher than post-pandemic scores (8.3 (1.6) vs 7 (1.8); p<0.01).\n\nSARS-CoV-2 has negatively impacted the surgical training, household income, and psychological/mental well-being of surgical gynecological oncology trainees. The overall clinical impact was worse for trainees in countries with no national training program than for those in countries with a national training program, although national training program trainees reported greater distress. COVID-19 sickness increased anxiety/depression. The recovery phase must focus on improving mental well-being and addressing lost training opportunities.", "doi": "10.1136/ijgc-2021-002803", "pmid": "34326158", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijgc-2021-002803"}], "notes": [], "created": "2021-08-04T17:05:43.480Z", "modified": "2021-08-04T17:05:43.612Z"}, {"entity": "publication", "iuid": "fa473254c88e438882b511fa003724f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa473254c88e438882b511fa003724f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa473254c88e438882b511fa003724f0"}}, "title": "Comparing the First and Second Wave of COVID-19 in Kidney Transplant Recipients: An East-European Perspective.", "authors": [{"family": "Elec", "given": "Florin Ioan", "initials": "FI"}, {"family": "Bolboac\u0103", "given": "Sorana D", "initials": "SD"}, {"family": "Muntean", "given": "Adriana", "initials": "A"}, {"family": "Elec", "given": "Alina Daciana", "initials": "AD"}, {"family": "Cismaru", "given": "Cristina", "initials": "C"}, {"family": "Lup\u015fe", "given": "Mihaela", "initials": "M"}, {"family": "Oltean", "given": "Mihai", "initials": "M"}], "type": "journal article", "published": "2021-07-29", "journal": {"title": "Eur Surg Res", "issn": "1421-9921", "pages": "1-8", "issn-l": null}, "abstract": "The present study examined whether patient characteristics, management, and outcome of kidney transplant recipients (KTx) with COVID-19 changed in the second versus the first pandemic wave.\n\nWe reviewed all available data (demographics, medical history, comorbidities, therapeutic interventions, and outcome) on our KTx with COVID-19 during the first wave (March-September 2020, n = 33) and the second wave (October 2020-February 2021, n = 149) of the COVID-19 pandemic.\n\nOne hundred eighty-two out of our 1,503 KTx in active follow-up got COVID-19 during 12-month period, corresponding to a prevalence of 12.1%. No difference was found in age, gender distribution, comorbidities, body mass index, or baseline immunosuppression between the 2 COVID-19 waves. Bilateral COVID pneumonia was more frequent during the first wave. More KTx were managed as outpatients during the second wave (15 vs. 39%, p < 0.01). Calcineurin inhibitors were more sparingly reduced during the second wave, whereas antimetabolites were similarly reduced (91 vs. 86, p = ns). Admission to intensive care units was comparable between the first (27%) and second waves (23%). During the first wave, 8 out of 9 patients (89%) requiring intensive care died, whereas the mortality of the ICU patients in the second wave was 68% (23 deaths) (p = 0.2). The overall mortality was 24% during the first wave and 16% during the second wave (p = 0.21), while in-hospital mortality was identical between the CO-VID-19 waves (27%). Increasing age and poor allograft function were significant predictors of mortality.\n\nMost patient characteristics and outcome were comparable between the first 2 COVID-19 waves. More KTx were managed as outpatients without an overall negative impact on outcome.", "doi": "10.1159/000517559", "pmid": "34325432", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "000517559"}], "notes": [], "created": "2021-08-04T17:06:31.650Z", "modified": "2021-08-04T17:06:31.673Z"}, {"entity": "publication", "iuid": "b509475ceaa74df8b64815bc18f6d147", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b509475ceaa74df8b64815bc18f6d147.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b509475ceaa74df8b64815bc18f6d147"}}, "title": "Body mass index and Mini Nutritional Assessment-Short Form as predictors of in-geriatric hospital mortality in older adults with COVID-19.", "authors": [{"family": "Kananen", "given": "L", "initials": "L"}, {"family": "Eriksdotter", "given": "M", "initials": "M"}, {"family": "Bostr\u00f6m", "given": "A M", "initials": "AM"}, {"family": "Kivipelto", "given": "M", "initials": "M"}, {"family": "Annetorp", "given": "M", "initials": "M"}, {"family": "Metzner", "given": "C", "initials": "C"}, {"family": "B\u00e4ck Jerlardtz", "given": "V", "initials": "V"}, {"family": "Engstr\u00f6m", "given": "M", "initials": "M"}, {"family": "Johnson", "given": "P", "initials": "P"}, {"family": "Lundberg", "given": "L G", "initials": "LG"}, {"family": "\u00c5kesson", "given": "E", "initials": "E"}, {"family": "S\u00fchl \u00d6berg", "given": "C", "initials": "C"}, {"family": "H\u00e4gg", "given": "S", "initials": "S"}, {"family": "Religa", "given": "D", "initials": "D"}, {"family": "Jylh\u00e4v\u00e4", "given": "J", "initials": "J"}, {"family": "Cederholm", "given": "T", "initials": "T"}], "type": "journal article", "published": "2021-07-29", "journal": {"title": "Clin Nutr", "issn": "1532-1983", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Overweight and obesity have been consistently reported to carry an increased risk for poorer outcomes in coronavirus disease 2019 (COVID-19) in adults. Existing reports mainly focus on in-hospital and intensive care unit mortality in patient cohorts usually not representative of the population with the highest mortality, i.e. the very old and frail patients. Accordingly, little is known about the risk patterns related to body mass and nutrition in very old patients. Our aim was to assess the relationship between body mass index (BMI), nutritional status and in-geriatric hospital mortality among geriatric patients treated for COVID-19. As a reference, the analyses were performed also in patients treated for other diagnoses than COVID-19.\r\n\r\nWe analyzed up to 10,031 geriatric patients with a median age of 83 years of which 1409 (14%) were hospitalized for COVID-19 and 8622 (86%) for other diagnoses in seven geriatric hospitals in the Stockholm region, Sweden during March 2020-January 2021. Data were available in electronic hospital records. The associations between 1) BMI and 2) nutritional status, assessed using the Mini-Nutritional Assessment - Short Form (MNA-SF) scale, and short-term in-geriatric hospital mortality were analyzed using logistic regression.\r\n\r\nAfter adjusting for age, sex, comorbidity, polypharmacy, frailty and the wave of the pandemic (first vs. second), underweight defined as BMI<18.5 increased the risk of in-hospital mortality in COVID-19 patients (odds ratio [OR] = 2.30; confidence interval [CI] = 1.17-4.31). Overweight and obesity were not associated with in-hospital mortality. Malnutrition; i.e. MNA-SF 0-7 points, increased the risk of in-hospital mortality in patients treated for COVID-19 (OR = 2.03; CI = 1.16-3.68) and other causes (OR = 6.01; CI = 2.73-15.91).\r\n\r\nOur results indicate that obesity is not a risk factor for very old patients with COVID-19, but emphasize the role of underweight and malnutrition for in-hospital mortality in geriatric patients with COVID-19.", "doi": "10.1016/j.clnu.2021.07.025", "pmid": "34389208", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S0261-5614(21)00360-5"}], "notes": [], "created": "2021-08-16T09:26:21.338Z", "modified": "2021-08-25T14:35:56.646Z"}, {"entity": "publication", "iuid": "2bb6cb4f6e9b41fd8ef541d2b6f39a10", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2bb6cb4f6e9b41fd8ef541d2b6f39a10.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2bb6cb4f6e9b41fd8ef541d2b6f39a10"}}, "title": "Artificial Intelligence for Hospital Health Care: Application Cases and Answers to Challenges in European Hospitals.", "authors": [{"family": "Klumpp", "given": "Matthias", "initials": "M", "orcid": "0000-0002-7543-2751", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15df94e4fcab4a0db6c1d14583233d27.json"}}, {"family": "Hintze", "given": "Marcus", "initials": "M"}, {"family": "Immonen", "given": "Milla", "initials": "M"}, {"family": "R\u00f3denas-Rigla", "given": "Francisco", "initials": "F", "orcid": "0000-0003-3264-4735", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0038ea81bcec424e9af333117f5e677d.json"}}, {"family": "Pilati", "given": "Francesco", "initials": "F"}, {"family": "Aparicio-Mart\u00ednez", "given": "Fernando", "initials": "F"}, {"family": "\u00c7elebi", "given": "Dilay", "initials": "D", "orcid": "0000-0002-7103-3868", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/367982752bd54431aa5bdec8f6492ffe.json"}}, {"family": "Liebig", "given": "Thomas", "initials": "T", "orcid": "0000-0002-9841-1101", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14a857c22bbd49cea833f737f7635f42.json"}}, {"family": "Jirstrand", "given": "Mats", "initials": "M"}, {"family": "Urbann", "given": "Oliver", "initials": "O"}, {"family": "Hedman", "given": "Marja", "initials": "M", "orcid": "0000-0003-1318-8287", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5bf03be491024743b39ff1f0a8ba1fbe.json"}}, {"family": "Lipponen", "given": "Jukka A", "initials": "JA"}, {"family": "Bicciato", "given": "Silvio", "initials": "S", "orcid": "0000-0002-1944-7078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/284edb100a1f46bb83a0a404bbf7ba5b.json"}}, {"family": "Radan", "given": "Anda-Petronela", "initials": "AP", "orcid": "0000-0003-0113-2761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f75f9ec5a49f45189aca88d7f525d10a.json"}}, {"family": "Valdivieso", "given": "Bernardo", "initials": "B"}, {"family": "Thronicke", "given": "Wolfgang", "initials": "W"}, {"family": "Gunopulos", "given": "Dimitrios", "initials": "D"}, {"family": "Delgado-Gonzalo", "given": "Ricard", "initials": "R"}], "type": "journal article", "published": "2021-07-29", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "volume": "9", "issue": "8", "issn-l": null}, "abstract": "The development and implementation of artificial intelligence (AI) applications in health care contexts is a concurrent research and management question. Especially for hospitals, the expectations regarding improved efficiency and effectiveness by the introduction of novel AI applications are huge. However, experiences with real-life AI use cases are still scarce. As a first step towards structuring and comparing such experiences, this paper is presenting a comparative approach from nine European hospitals and eleven different use cases with possible application areas and benefits of hospital AI technologies. This is structured as a current review and opinion article from a diverse range of researchers and health care professionals. This contributes to important improvement options also for pandemic crises challenges, e.g., the current COVID-19 situation. The expected advantages as well as challenges regarding data protection, privacy, or human acceptance are reported. Altogether, the diversity of application cases is a core characteristic of AI applications in hospitals, and this requires a specific approach for successful implementation in the health care sector. This can include specialized solutions for hospitals regarding human-computer interaction, data management, and communication in AI implementation projects.", "doi": "10.3390/healthcare9080961", "pmid": "34442098", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "healthcare9080961"}, {"db": "pmc", "key": "PMC8393951"}], "notes": [], "created": "2021-09-01T07:15:14.462Z", "modified": "2021-09-01T07:15:14.633Z"}, {"entity": "publication", "iuid": "2ab52f4459a74cbd88570d67b152abcd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ab52f4459a74cbd88570d67b152abcd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ab52f4459a74cbd88570d67b152abcd"}}, "title": "Why women choose at-home abortion via teleconsultation in France: drivers of telemedicine abortion during and beyond the COVID-19 pandemic.", "authors": [{"family": "Atay", "given": "Hazal", "initials": "H", "orcid": "0000-0002-1634-6060", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/135c2f41c76e45a991573192b054aa03.json"}}, {"family": "Perivier", "given": "Helene", "initials": "H"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}, {"family": "Guilleminot", "given": "Jean", "initials": "J"}, {"family": "Hassoun", "given": "Danielle", "initials": "D"}, {"family": "Hottois", "given": "Judith", "initials": "J"}, {"family": "Gomperts", "given": "Rebecca", "initials": "R"}, {"family": "Levrier", "given": "Emmanuelle", "initials": "E"}], "type": "journal article", "published": "2021-07-28", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-2009", "issn-l": "2515-1991"}, "abstract": "In an attempt to understand the demand and main drivers of telemedicine abortion, we analysed the requests that Women on Web (WoW), an online telemedicine abortion service operating worldwide, received from France throughout 2020.\n\nWe conducted a parallel, convergent, mixed-methods study among 809 consultations received from France at WoW between 1 January and 31 December 2020. We performed a cross-sectional study of data obtained from the WoW consultation survey and a manifest content analysis of anonymised email correspondence of 140 women consulting with the WoW helpdesk from France.\n\nWe found that women encounter macro-level, individual-level and provider-level constraints while trying to access abortion in France. The preferences and needs over secrecy (n=356, 46.2%), privacy (n=295, 38.3%) and comfort (n=269, 34.9%) are among the most frequent reasons for women from France to choose telemedicine abortion through WoW. The COVID-19 pandemic seems to be an important driver for resorting to telemedicine (n=236, 30.6%). The lockdowns had a significant impact on the number of consultations received at WoW from France, increasing from 60 in March to 128 in April during the first lockdown and from 54 in October to 80 in November during the second lockdown.\n\nThe demand for at-home medical abortion via teleconsultation increased in France during the lockdowns. However, drivers of telemedicine abortion are multidimensional and go beyond the conditions unique to the pandemic.", "doi": "10.1136/bmjsrh-2021-201176", "pmid": "34321255", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjsrh-2021-201176"}], "notes": [], "created": "2021-08-04T17:09:36.988Z", "modified": "2021-08-04T17:09:37.026Z"}, {"entity": "publication", "iuid": "4de11e08768e477eb00fa08e3d787692", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4de11e08768e477eb00fa08e3d787692.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4de11e08768e477eb00fa08e3d787692"}}, "title": "SARS-CoV-2 Spike Protein Extrapolation for COVID Diagnosis and Vaccine Development.", "authors": [{"family": "Malik", "given": "Yashpal S", "initials": "YS"}, {"family": "Kumar", "given": "Prashant", "initials": "P"}, {"family": "Ansari", "given": "Mohd Ikram", "initials": "MI"}, {"family": "Hemida", "given": "Maged G", "initials": "MG"}, {"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME"}, {"family": "Abdel-Moneim", "given": "Ahmed S", "initials": "AS"}, {"family": "Ganesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Salajegheh", "given": "Sina", "initials": "S"}, {"family": "Natesan", "given": "Senthilkumar", "initials": "S"}, {"family": "Sircar", "given": "Shubhankar", "initials": "S"}, {"family": "Safdar", "given": "Muhammad", "initials": "M"}, {"family": "Vinodhkumar", "given": "O R", "initials": "OR"}, {"family": "Duarte", "given": "Phelipe M", "initials": "PM"}, {"family": "Patel", "given": "Shailesh K", "initials": "SK"}, {"family": "Klein", "given": "J\u00f6rn", "initials": "J"}, {"family": "Rahimi", "given": "Parastoo", "initials": "P"}, {"family": "Dhama", "given": "Kuldeep", "initials": "K"}], "type": "journal article", "published": "2021-07-28", "journal": {"title": "Front. Mol. Biosci.", "issn": "2296-889X", "volume": "8", "pages": "607886", "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to coronavirus disease 2019 (COVID-19) pandemic affecting nearly 71.2 million humans in more than 191 countries, with more than 1.6 million mortalities as of 12 December, 2020. The spike glycoprotein (S-protein), anchored onto the virus envelope, is the trimer of S-protein comprised of S1 and S2 domains which interacts with host cell receptors and facilitates virus-cell membrane fusion. The S1 domain comprises of a receptor binding domain (RBD) possessing an N-terminal domain and two subdomains (SD1 and SD2). Certain regions of S-protein of SARS-CoV-2 such as S2 domain and fragment of the RBD remain conserved despite the high selection pressure. These conserved regions of the S-protein are extrapolated as the potential target for developing molecular diagnostic techniques. Further, the S-protein acts as an antigenic target for different serological assay platforms for the diagnosis of COVID-19. Virus-specific IgM and IgG antibodies can be used to detect viral proteins in ELISA and lateral flow immunoassays. The S-protein of SARS-CoV-2 has very high sequence similarity to SARS-CoV-1, and the monoclonal antibodies (mAbs) against SARS-CoV-1 cross-react with S-protein of SARS-CoV-2 and neutralize its activity. Furthermore, in vitro studies have demonstrated that polyclonal antibodies targeted against the RBD of S-protein of SARS-CoV-1 can neutralize SARS-CoV-2 thus inhibiting its infectivity in permissive cell lines. Research on coronaviral S-proteins paves the way for the development of vaccines that may prevent SARS-CoV-2 infection and alleviate the current global coronavirus pandemic. However, specific neutralizing mAbs against SARS-CoV-2 are in clinical development. Therefore, neutralizing antibodies targeting SARS-CoV-2 S-protein are promising specific antiviral therapeutics for pre-and post-exposure prophylaxis and treatment of SARS-CoV-2 infection. We hereby review the approaches taken by researchers across the world to use spike gene and S-glycoprotein for the development of effective diagnostics, vaccines and therapeutics against SARA-CoV-2 infection the COVID-19 pandemic.", "doi": "10.3389/fmolb.2021.607886", "pmid": "34395515", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8355592"}], "notes": [], "created": "2021-08-17T06:42:35.226Z", "modified": "2021-08-17T06:42:35.238Z"}, {"entity": "publication", "iuid": "5b83a052d34a4d6c8974f2c1df4b38e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5b83a052d34a4d6c8974f2c1df4b38e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5b83a052d34a4d6c8974f2c1df4b38e8"}}, "title": "High-flow nasal oxygen (HFNO) for patients with Covid-19 outside intensive care units.", "authors": [{"family": "Issa", "given": "Issa", "initials": "I"}, {"family": "S\u00f6derberg", "given": "M\u00e5rten", "initials": "M"}], "type": "journal article", "published": "2021-07-28", "journal": {"title": "Respir Med", "issn": "1532-3064", "volume": "187", "pages": "106554", "issn-l": "0954-6111"}, "abstract": "High-flow nasal oxygen (HFNO) has traditionally only been used in intensive care units (ICU) especially in acute respiratory distress syndrome (ARDS).\n\nWe studied the use of HFNO at S\u00f6dersjukhuset, Stockholm, in patients with moderate to severe ARDS related to Covid-19 as well as its benefits both for patients and to offload the ICU. The patients were observed with frequent controls to assess the need of ICU in case of deterioration.\n\nWe studied 41 patients with HFNO treatment either as primarily treatment (Step-Up) or after stabilizing in the ICU (Step-Down). The average duration for treatment with HFNO was 5.6 days. Of these patients 55% were discharged home or to geriatric rehabilitation and 10% avoided ICU completely. The usage of HFNO saved in total 229 days in the ICU. Mortality was higher among elderly patients, and patients with comorbidities (mainly hypertension and obesity).\n\nHFNO treatment is feasible and efficient for patients with Covid-19, saving resources in the ICU and offering additional advantages as waken proning and fewer complications compared to traditional ICU care. It requires however frequent controls as deterioration is recurrent.", "doi": "10.1016/j.rmed.2021.106554", "pmid": "34340173", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0954-6111(21)00260-2"}], "notes": [], "created": "2021-08-04T10:10:08.771Z", "modified": "2021-08-04T10:10:08.782Z"}, {"entity": "publication", "iuid": "90f29222ad714723bbd9ced04cad354e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90f29222ad714723bbd9ced04cad354e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90f29222ad714723bbd9ced04cad354e"}}, "title": "Risk perception, treatment adherence, and personality during COVID-19 pandemic: An international study on cancer patients.", "authors": [{"family": "Cheli", "given": "Simone", "initials": "S", "orcid": "0000-0002-0432-3769", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d454912b2b7463e9f09b0c32954570f.json"}}, {"family": "Lam", "given": "Wendy W T", "initials": "WWT", "orcid": "0000-0003-2383-0149", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72b193d3e93e4db0b1b69bcf36e8199e.json"}}, {"family": "Estap\u00e9", "given": "Tania", "initials": "T", "orcid": "0000-0001-9792-2586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28a910dd36ee4e51947763acf49bd12b.json"}}, {"family": "Winterling", "given": "Jeanette", "initials": "J", "orcid": "0000-0003-4165-9015", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/334f6c0ee8d047b88231d04d2b148e45.json"}}, {"family": "Bahcivan", "given": "Ozan", "initials": "O"}, {"family": "Andritsch", "given": "Elisabeth", "initials": "E"}, {"family": "Weis", "given": "Joachim", "initials": "J", "orcid": "0000-0002-8646-6607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/38e0112be6eb448f821b51aab7e439d3.json"}}, {"family": "Centeno", "given": "Isabel", "initials": "I"}, {"family": "Serpentini", "given": "Samantha", "initials": "S", "orcid": "0000-0002-0517-3416", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/731e1839e02544c38db8553cab833149.json"}}, {"family": "Farkas", "given": "Clemens", "initials": "C"}, {"family": "Wengstr\u00f6m", "given": "Yvonne", "initials": "Y"}, {"family": "Fioretto", "given": "Luisa", "initials": "L"}, {"family": "Baider", "given": "Lea", "initials": "L"}, {"family": "Lam", "given": "Cherry C L", "initials": "CCL"}, {"family": "Goldzweig", "given": "Gil", "initials": "G", "orcid": "0000-0003-2295-1627", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5adb0c7e08ff46938308ba55a450ddee.json"}}], "type": "journal article", "published": "2021-07-27", "journal": {"title": "Psychooncology", "issn": "1099-1611", "issn-l": null}, "abstract": "To explore the role of personality traits in moderating the relation between COVID-19 risk perception and treatment adherence, and between risk perception and psychosocial distress in patients diagnosed with cancer.\n\nAn online survey (n = 1281) was conducted worldwide in seven countries (Austria, Germany, Hong Kong, Italy, Spain, Sweden, and Turkey). Inclusion criteria were to be 18 years of age or older, have received a cancer diagnosis, and be in treatment or follow-up. A few moderated regression models were performed with both personality traits and Hierarchical Taxonomy of Psychopathology super-spectra as moderators.\n\nDetachment, negative affectivity, psychoticism and all the super-spectra significantly moderated the relation between coronavirus risk perception and psychosocial distress, after the adjusting effect of confidence in safeguards. Only negative affectivity moderated the association between coronavirus risk perception and treatment adherence.\n\nPersonality traits may foster the understanding of how a patient might adjust to cancer treatment and, more generically, to highly stressful events such as the COVID-19 pandemic. Further research is needed to confirm the results in different cancer stages and types.", "doi": "10.1002/pon.5775", "pmid": "34314560", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-05T06:49:17.670Z", "modified": "2021-08-05T06:49:56.380Z"}, {"entity": "publication", "iuid": "874dc3a385944b54abd448b449c42852", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/874dc3a385944b54abd448b449c42852.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/874dc3a385944b54abd448b449c42852"}}, "title": "Insomnia episodes, new-onset pharmacological treatments and other sleep disturbances during the COVID-19 pandemic: a nationwide cross-sectional study in Brazilian health care professionals.", "authors": [{"family": "Drager", "given": "Luciano F", "initials": "LF"}, {"family": "Pachito", "given": "Daniela V", "initials": "DV"}, {"family": "Moreno", "given": "Claudia R C", "initials": "CRC"}, {"family": "Tavares", "given": "Almir R", "initials": "AR"}, {"family": "Conway", "given": "Silvia G", "initials": "SG"}, {"family": "Assis", "given": "M\u00e1rcia", "initials": "M"}, {"family": "Sguillar", "given": "Danilo A", "initials": "DA"}, {"family": "Moreira", "given": "Gustavo A", "initials": "GA"}, {"family": "Bacelar", "given": "Andrea", "initials": "A"}, {"family": "Genta", "given": "Pedro R", "initials": "PR"}], "type": "journal article", "published": "2021-07-27", "journal": {"title": "J Clin Sleep Med", "issn": "1550-9397", "issn-l": null}, "abstract": "To evaluate the impact of COVID-19 pandemic on insomnia and other sleep disturbances in health care professionals.\n\nA survey was distributed using social media and organizational emails to Brazilian active health care professionals during the COVID-19 outbreak. We explored potential associated factors including age, gender, occupation, workplace, work hours, income, previous infection with COVID-19, recent/current contact with COVID-19 patients, regional number of incident deaths, anxiety, and burnout. We evaluated new-onset/ previous insomnia worsening episodes (primary outcome), new pharmacological treatments, sleep quality, duration, nightmares and snoring (secondary outcomes).\n\nA total of 4,384 health professionals from all regions of the country were included in the analysis (44\u00b112 years, 76% females, 53.8% physicians). Overall, 55.7% were assisting patients with COVID-19, and 9.2% had a previous COVID-19 infection. The primary outcome occurred in 32.9% of respondents in parallel to 13% new pharmacological treatments for insomnia. The sleep quality worsened for 61.4%, while 43.5% and 22.8% reported \u22651-hour sleep duration reduction and worsening or new-onset nightmares, respectively. Multivariate analyses showed that age (OR:1.008; 95% CI 1.001-1.015), females (OR:1.590; 95% CI 1.335-1.900), weight change (decrease: OR:1.772; 95% CI 1.453-2.161; increase: OR:1.468; 95% CI 1.249-1.728), prevalent anxiety (OR:3.414; 95% CI 2.954-3.948), new-onset burnout (OR:1.761; 95% CI 1.489-2.083), family income reduction >30% (OR:1.288; 95% CI 1.069-1.553) and assisting patients with COVID-19 (OR:1.275; 95% CI 1.081-1.506) were independently associated with new-onset or worsening of previous insomnia episodes.\n\nWe observed a huge burden of insomnia episodes and other sleep disturbances in health care professionals during the COVID-19 pandemic.", "doi": "10.5664/jcsm.9570", "pmid": "34314346", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-05T06:50:22.198Z", "modified": "2021-11-18T12:41:20.850Z"}, {"entity": "publication", "iuid": "6c0622945cb14014a699e3ce3788c348", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c0622945cb14014a699e3ce3788c348.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c0622945cb14014a699e3ce3788c348"}}, "title": "Impact of tiered restrictions on human activities and the epidemiology of the second wave of COVID-19 in Italy.", "authors": [{"family": "Manica", "given": "Mattia", "initials": "M", "orcid": "0000-0003-3709-1199", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f1dee2cd796464983ca73416f1ba644.json"}}, {"family": "Guzzetta", "given": "Giorgio", "initials": "G"}, {"family": "Riccardo", "given": "Flavia", "initials": "F", "orcid": "0000-0002-1582-6329", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db383a5731dd4bb1aa8ff4c1cac91455.json"}}, {"family": "Valenti", "given": "Antonio", "initials": "A"}, {"family": "Poletti", "given": "Piero", "initials": "P", "orcid": "0000-0001-5453-5199", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e47d12a6b4954f45b9cf7c10f53aea19.json"}}, {"family": "Marziano", "given": "Valentina", "initials": "V", "orcid": "0000-0003-2842-7906", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9548ac3b58a249708f9ad8a835f42794.json"}}, {"family": "Trentini", "given": "Filippo", "initials": "F", "orcid": "0000-0001-6915-7282", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1ef47385a014489af492240312faded.json"}}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A", "orcid": "0000-0002-0480-8723", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96fca74501fd40f59359426781336b42.json"}}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Vescio", "given": "Maria Fenicia", "initials": "MF", "orcid": "0000-0002-3285-919X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fb4525bc8684390b022335a044b9db8.json"}}, {"family": "Spuri", "given": "Matteo", "initials": "M"}, {"family": "Petrone", "given": "Daniele", "initials": "D"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Iavicoli", "given": "Sergio", "initials": "S"}, {"family": "Ajelli", "given": "Marco", "initials": "M", "orcid": "0000-0003-1753-4749", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e1711c9d1c04770b118631d74173efd.json"}}, {"family": "Brusaferro", "given": "Silvio", "initials": "S"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P", "orcid": "0000-0002-0805-2927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/95cf0a950b334a61a4420f778420d114.json"}}, {"family": "Merler", "given": "Stefano", "initials": "S", "orcid": "0000-0002-5117-0611", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/380ed711c37a41e49c4b4f53ab0636af.json"}}], "type": "journal article", "published": "2021-07-27", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "4570", "issn-l": "2041-1723"}, "abstract": "To counter the second COVID-19 wave in autumn 2020, the Italian government introduced a system of physical distancing measures organized in progressively restrictive tiers (coded as yellow, orange, and red) imposed on a regional basis according to real-time epidemiological risk assessments. We leverage the data from the Italian COVID-19 integrated surveillance system and publicly available mobility data to evaluate the impact of the three-tiered regional restriction system on human activities, SARS-CoV-2 transmissibility and hospitalization burden in Italy. The individuals' attendance to locations outside the residential settings was progressively reduced with tiers, but less than during the national lockdown against the first COVID-19 wave in the spring. The reproduction number R(t) decreased below the epidemic threshold in 85 out of 107 provinces after the introduction of the tier system, reaching average values of about 0.95-1.02 in the yellow tier, 0.80-0.93 in the orange tier and 0.74-0.83 in the red tier. We estimate that the reduced transmissibility resulted in averting about 36% of the hospitalizations between November 6 and November 25, 2020. These results are instrumental to inform public health efforts aimed at preventing future resurgence of cases.", "doi": "10.1038/s41467-021-24832-z", "pmid": "34315899", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-24832-z"}, {"db": "pmc", "key": "PMC8316570"}, {"db": "URL", "key": "https://doi.org/10.6084/m9.figshare.14153351.v1", "description": "Mobility and epidemiological data"}], "notes": [], "created": "2021-08-05T06:48:17.298Z", "modified": "2021-11-18T12:40:09.354Z"}, {"entity": "publication", "iuid": "e6060ed659914e25af19d827947cbde6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6060ed659914e25af19d827947cbde6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6060ed659914e25af19d827947cbde6"}}, "title": "Emergence of an early SARS-CoV-2 epidemic in the United States.", "authors": [{"family": "Zeller", "given": "Mark", "initials": "M"}, {"family": "Gangavarapu", "given": "Karthik", "initials": "K"}, {"family": "Anderson", "given": "Catelyn", "initials": "C"}, {"family": "Smither", "given": "Allison R", "initials": "AR"}, {"family": "Vanchiere", "given": "John A", "initials": "JA"}, {"family": "Rose", "given": "Rebecca", "initials": "R"}, {"family": "Snyder", "given": "Daniel J", "initials": "DJ"}, {"family": "Dudas", "given": "Gytis", "initials": "G"}, {"family": "Watts", "given": "Alexander", "initials": "A"}, {"family": "Matteson", "given": "Nathaniel L", "initials": "NL"}, {"family": "Robles-Sikisaka", "given": "Refugio", "initials": "R"}, {"family": "Marshall", "given": "Maximilian", "initials": "M"}, {"family": "Feehan", "given": "Amy K", "initials": "AK"}, {"family": "Sabino-Santos", "given": "Gilberto", "initials": "G"}, {"family": "Bell-Kareem", "given": "Antoinette R", "initials": "AR"}, {"family": "Hughes", "given": "Laura D", "initials": "LD"}, {"family": "Alkuzweny", "given": "Manar", "initials": "M"}, {"family": "Snarski", "given": "Patricia", "initials": "P"}, {"family": "Garcia-Diaz", "given": "Julia", "initials": "J"}, {"family": "Scott", "given": "Rona S", "initials": "RS"}, {"family": "Melnik", "given": "Lilia I", "initials": "LI"}, {"family": "Klitting", "given": "Rapha\u00eblle", "initials": "R"}, {"family": "McGraw", "given": "Michelle", "initials": "M"}, {"family": "Belda-Ferre", "given": "Pedro", "initials": "P"}, {"family": "DeHoff", "given": "Peter", "initials": "P"}, {"family": "Sathe", "given": "Shashank", "initials": "S"}, {"family": "Marotz", "given": "Clarisse", "initials": "C"}, {"family": "Grubaugh", "given": "Nathan D", "initials": "ND"}, {"family": "Nolan", "given": "David J", "initials": "DJ"}, {"family": "Drouin", "given": "Arnaud C", "initials": "AC"}, {"family": "Genemaras", "given": "Kaylynn J", "initials": "KJ"}, {"family": "Chao", "given": "Karissa", "initials": "K"}, {"family": "Topol", "given": "Sarah", "initials": "S"}, {"family": "Spencer", "given": "Emily", "initials": "E"}, {"family": "Nicholson", "given": "Laura", "initials": "L"}, {"family": "Aigner", "given": "Stefan", "initials": "S"}, {"family": "Yeo", "given": "Gene W", "initials": "GW"}, {"family": "Farnaes", "given": "Lauge", "initials": "L"}, {"family": "Hobbs", "given": "Charlotte A", "initials": "CA"}, {"family": "Laurent", "given": "Louise C", "initials": "LC"}, {"family": "Knight", "given": "Rob", "initials": "R"}, {"family": "Hodcroft", "given": "Emma B", "initials": "EB"}, {"family": "Khan", "given": "Kamran", "initials": "K"}, {"family": "Fusco", "given": "Dahlene N", "initials": "DN"}, {"family": "Cooper", "given": "Vaughn S", "initials": "VS"}, {"family": "Lemey", "given": "Phillipe", "initials": "P"}, {"family": "Gardner", "given": "Lauren", "initials": "L"}, {"family": "Lamers", "given": "Susanna L", "initials": "SL"}, {"family": "Kamil", "given": "Jeremy P", "initials": "JP"}, {"family": "Garry", "given": "Robert F", "initials": "RF"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Andersen", "given": "Kristian G", "initials": "KG"}], "type": "journal article", "published": "2021-07-27", "journal": {"title": "Cell", "issn": "1097-4172", "issn-l": "0092-8674"}, "abstract": "The emergence of the COVID-19 epidemic in the United States (U.S.) went largely undetected due to inadequate testing. New Orleans experienced one of the earliest and fastest accelerating outbreaks, coinciding with Mardi Gras. To gain insight into the emergence of SARS-CoV-2 in the U.S. and how large-scale events accelerate transmission, we sequenced SARS-CoV-2 genomes during the first wave of the COVID-19 epidemic in Louisiana. We show that SARS-CoV-2 in Louisiana had limited diversity compared to other U.S. states and that one introduction of SARS-CoV-2 led to almost all of the early transmission in Louisiana. By analyzing mobility and genomic data, we show that SARS-CoV-2 was already present in New Orleans before Mardi Gras, and the festival dramatically accelerated transmission. Our study provides an understanding of how superspreading during large-scale events played a key role during the early outbreak in the U.S. and can greatly accelerate epidemics.", "doi": "10.1016/j.cell.2021.07.030", "pmid": "34508652", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "S0092-8674(21)00889-8"}], "notes": [], "created": "2021-09-13T06:27:48.982Z", "modified": "2021-09-13T06:28:12.476Z"}, {"entity": "publication", "iuid": "744226cc5c5144879e5767e369df749d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/744226cc5c5144879e5767e369df749d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/744226cc5c5144879e5767e369df749d"}}, "title": "Publisher Correction: A SARS-CoV-2 (COVID-19) biological network to find targets for drug repurposing.", "authors": [{"family": "Habibi", "given": "Mahnaz", "initials": "M"}, {"family": "Taheri", "given": "Golnaz", "initials": "G"}, {"family": "Aghdam", "given": "Rosa", "initials": "R"}], "type": "published erratum", "published": "2021-07-26", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "15550", "issn-l": "2045-2322"}, "abstract": null, "doi": "10.1038/s41598-021-94440-w", "pmid": "34312434", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-94440-w"}, {"db": "pmc", "key": "PMC8312203"}], "notes": [], "created": "2021-08-05T06:51:19.646Z", "modified": "2021-08-05T06:51:32.486Z"}, {"entity": "publication", "iuid": "26ad1c470c1947dd88ed132b5289fe00", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26ad1c470c1947dd88ed132b5289fe00.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26ad1c470c1947dd88ed132b5289fe00"}}, "title": "Gambling-Like Day Trading During the COVID-19 Pandemic \u2013 Need for Research on a Pandemic-Related Risk of Indebtedness and Mental Health Impact", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "Fern\u00e1ndez-Aranda", "given": "Fernando", "initials": "F"}, {"family": "Jim\u00e9nez-Murcia", "given": "Susana", "initials": "S"}], "type": "journal-article", "published": "2021-07-26", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "issn-l": "1664-0640"}, "abstract": null, "doi": "10.3389/fpsyt.2021.715946", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-12T17:08:51.507Z", "modified": "2021-08-12T17:08:51.518Z"}, {"entity": "publication", "iuid": "be66ed79c9a94526a346fadd6606bbda", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be66ed79c9a94526a346fadd6606bbda.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be66ed79c9a94526a346fadd6606bbda"}}, "title": "Echocardiographic characterisation in critical Covid19 - an observational study", "authors": [{"family": "Isackson", "given": "Henrik", "initials": "H"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Flachskampf", "given": "Frank A", "initials": "FA"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}], "type": "posted-content", "published": "2021-07-26", "journal": {"title": "MedRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.07.23.21261025", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [], "notes": [], "created": "2021-08-03T11:38:30.872Z", "modified": "2022-02-09T10:24:26.569Z"}, {"entity": "publication", "iuid": "52a5191b1d05485fbf2afe5aa5526c84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/52a5191b1d05485fbf2afe5aa5526c84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/52a5191b1d05485fbf2afe5aa5526c84"}}, "title": "Detection and viral RNA shedding of SARS-CoV-2 in respiratory specimens relative to symptom onset among COVID-19 patients in Bavaria, Germany - Addendum.", "authors": [{"family": "Woudenberg", "given": "Tom", "initials": "T"}, {"family": "Eberle", "given": "Ute", "initials": "U"}, {"family": "Marosevic", "given": "Durdica", "initials": "D"}, {"family": "Liebl", "given": "Bernhard", "initials": "B"}, {"family": "Ackermann", "given": "Nikolaus", "initials": "N"}, {"family": "Katz", "given": "Katharina", "initials": "K"}, {"family": "Sing", "given": "Andreas", "initials": "A"}, {"family": "Bavarian SARS-CoV-2-Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-07-26", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": "149", "pages": "e167", "issn-l": null}, "abstract": null, "doi": "10.1017/S095026882100159X", "pmid": "34308806", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8314188"}, {"db": "pii", "key": "S095026882100159X"}], "notes": [], "created": "2021-08-05T06:52:32.877Z", "modified": "2023-06-19T15:23:43.663Z"}, {"entity": "publication", "iuid": "510a4bcdc52d4274b4982a084c7413ed", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/510a4bcdc52d4274b4982a084c7413ed.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/510a4bcdc52d4274b4982a084c7413ed"}}, "title": "Depressive symptoms and perception of risk during the first wave of the COVID-19 pandemic: A web-based cross-country comparative survey.", "authors": [{"family": "Terraneo", "given": "Marco", "initials": "M", "orcid": "0000-0003-1072-2923", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8940f795351451582749a735ac7d10e.json"}}, {"family": "Lombi", "given": "Linda", "initials": "L"}, {"family": "Bradby", "given": "Hannah", "initials": "H", "orcid": "0000-0002-0664-1170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6650bd723f06404cb9f068d9bda13541.json"}}], "type": "journal article", "published": "2021-07-26", "journal": {"title": "Sociol Health Illn", "issn": "1467-9566", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Evidence is accumulating of the negative impact of the COVID-19 pandemic and related public health measures on mental health. In this emergent field, there has been little research into the role of risk perception on depressive symptoms and the contribution of health-care resources to model risk perception and mental health. The aim of this paper is to describe the relationship between individual-level perception of risk and depression, controlling for a set of confounders and for country-level heterogeneity. A cross-sectional and observational online survey was conducted using a non-probability snowball sampling technique. We use data on 11,340 respondents, living in six European countries (Italy, Sweden, United Kingdom, France, Poland, Czech Republic) who completed survey questionnaires during the first months of the pandemic. We used a fixed-effect approach, which included individual and macro-level variables. The findings suggest that a high proportion of people suffering from depression and heightened risk perception is positively associated with reporting depressive symptoms, even if this relationship varies significantly between countries. Moreover, the association is moderated by contextual factors including health-care expenditure as a percentage of Gross Domestic Product, hospital beds for acute care, and number of medical specialists per head of population. Investment in health care offers a concrete means of protecting the mental health of a population living under pandemic restrictions.", "doi": "10.1111/1467-9566.13350", "pmid": "34309032", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-05T06:52:12.792Z", "modified": "2021-11-18T12:06:01.508Z"}, {"entity": "publication", "iuid": "9f1ffdda0e594d7d91e8fb212c9f63a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f1ffdda0e594d7d91e8fb212c9f63a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f1ffdda0e594d7d91e8fb212c9f63a0"}}, "title": "Conditions and strategies to meet the challenges imposed by the COVID-19-related visiting restrictions in the intensive care unit: A Scandinavian cross-sectional study.", "authors": [{"family": "Jensen", "given": "Hanne Irene", "initials": "HI"}, {"family": "\u00c5kerman", "given": "Eva", "initials": "E"}, {"family": "Lind", "given": "Ranveig", "initials": "R"}, {"family": "Alfheim", "given": "Hanne Birgit", "initials": "HB"}, {"family": "Frivold", "given": "Gro", "initials": "G"}, {"family": "Fridh", "given": "Isabell", "initials": "I"}, {"family": "\u00c5g\u00e5rd", "given": "Anne Sophie", "initials": "AS"}], "type": "journal article", "published": "2021-07-26", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "issn-l": null, "volume": null, "issue": null, "pages": "103116"}, "abstract": "To examine conditions and strategies to meet the challenges imposed by the coronavirus disease 2019 (COVID-19)-related visiting restrictions in Scandinavian intensive care units.\r\n\r\nA cross-sectional survey.\r\n\r\nAdult intensive care units in Denmark, Norway and Sweden.\r\n\r\nLikert scale responses and free-text comments within six areas: capacity and staffing, visiting policies and access to the unit, information and conferences with relatives, written information, children as relatives and follow-up initiatives.\r\n\r\nThe overall response rate was 53% (74/140 participating units). All intensive care units had planned for capacity extensions; the majority ranging between 11 and 30 extra beds. From March-June 2020, units had a mean maximum of 9.4 COVID-19 patients simultaneously. Allowing restricted visiting was more common in Denmark (52%) and Norway (61%) than in Sweden where visiting was mostly denied except for dying patients (68%), due to a particular increased number of COVID-19 patients. The restrictions forced nurses to compromise on their usual standards of family care. Numerous models for maintaining contact between relatives and patients were described.\r\n\r\nVisitation restrictions compromised the quality of family care and entailed dilemmas for healthcare professionals but also spurred initiatives to developing new ways of providing family care.", "doi": "10.1016/j.iccn.2021.103116", "pmid": "34391628", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(21)00105-1"}], "notes": [], "created": "2021-08-16T09:32:10.498Z", "modified": "2021-11-18T11:59:47.254Z"}, {"entity": "publication", "iuid": "1ccaf39e6fd54c4282412ead18d1c405", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ccaf39e6fd54c4282412ead18d1c405.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ccaf39e6fd54c4282412ead18d1c405"}}, "title": "Recurrent and persistent infection with SARS-CoV-2 - epidemiological data and case reports from Western Sweden, 2020.", "authors": [{"family": "Ringlander", "given": "Johan", "initials": "J", "orcid": "0000-0002-8483-6504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64f85af7dceb436498422e62f1a98c89.json"}}, {"family": "Olausson", "given": "Josefin", "initials": "J"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "H\u00e4rnqvist", "given": "Tor", "initials": "T"}, {"family": "Jakobsson", "given": "Hedvig E", "initials": "HE"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-07-24", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": null, "issue": null, "pages": "1-8"}, "abstract": "Reinfections with SARS-CoV-2 have been reported and most cases were classified as mild. Reports of persistent infection with SARS-CoV-2 are rare.\r\n\r\nTo investigate the frequency of recurrent and persistent infection with SARS-CoV-2.\r\n\r\nPossible cases of reinfection and persistent infection were retrospectively identified in a database of 59,998 patients. Deep sequencing of SARS-CoV-2 genomes was performed.\r\n\r\nWe report the first case of COVID-19 reinfection in Sweden and three cases of infection with persistence over several months. The rate of sequencing-verified reinfection was 0.02% (one patient out of 6014 patients testing positive during the period).\r\n\r\nThe reinfected patient had mild symptoms during the second episode, which might reflect partial immunity. The frequency of reinfection during the first wave of the pandemic in western Sweden was very low. Our results indicate that elderly with a putative reinfection more likely have persistent COVID-19.", "doi": "10.1080/23744235.2021.1957143", "pmid": "34308755", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "URL", "key": "https://www.tandfonline.com/doi/figure/10.1080/23744235.2021.1957143?scroll=top&needAccess=true", "description": "Nucleotide differences between the first infection and second infection strains from one patient with reinfection"}], "notes": [], "created": "2021-08-05T06:52:53.774Z", "modified": "2021-11-18T11:56:46.277Z"}, {"entity": "publication", "iuid": "d585588f3a9c4c0aac93cdf21af3264f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d585588f3a9c4c0aac93cdf21af3264f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d585588f3a9c4c0aac93cdf21af3264f"}}, "title": "Profiling lockdown adherence and poor coping responses towards the COVID-19 crisis in an international cross-sectional survey", "authors": [{"family": "Van Belle", "given": "Sylvia", "initials": "S", "orcid": "0000-0002-6247-5832", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bffd346b0f96471e9b815246904378e8.json"}}, {"family": "Dahl\u00e9n", "given": "Amelia", "initials": "A"}, {"family": "Schi\u00f6th", "given": "Helgi B", "initials": "HB", "orcid": "0000-0001-7112-0921", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ec43532c42c4ee5b79a470fede7d088.json"}}, {"family": "Brooks", "given": "Samantha J", "initials": "SJ", "orcid": "0000-0002-9146-6257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef6c03915d334cd3bbefbe6508397561.json"}}], "type": "posted-content", "published": "2021-07-24", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.07.21.21260910", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-08-03T11:41:30.941Z", "modified": "2021-11-19T11:26:33.994Z"}, {"entity": "publication", "iuid": "e97f8e5f6fd241c2bdd9c2ae9b51e552", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e97f8e5f6fd241c2bdd9c2ae9b51e552.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e97f8e5f6fd241c2bdd9c2ae9b51e552"}}, "title": "Pandemic backsliding: Violations of democratic standards during Covid-19.", "authors": [{"family": "Edgell", "given": "Amanda B", "initials": "AB"}, {"family": "Lachapelle", "given": "Jean", "initials": "J"}, {"family": "L\u00fchrmann", "given": "Anna", "initials": "A"}, {"family": "Maerz", "given": "Seraphine F", "initials": "SF"}], "type": "journal article", "published": "2021-07-24", "journal": {"title": "Soc Sci Med", "issn": "1873-5347", "issn-l": null, "volume": "285", "issue": null, "pages": "114244"}, "abstract": "The widespread adoption of emergency powers during Covid-19 raises important questions about what constitutes a (un)democratic response to crises. While the institutions and practices of democracy during normal times are well established, democratic standards during emergencies have yet to be conceptualized in the literature. This makes it difficult to systematically answer questions like - How do states' responses to Covid-19 violate democratic standards? Do such violations make states' responses more effective? Drawing on international treaties, norms, and academic scholarship, we propose a novel conceptualization of democratic standards for emergency measures. We then identify which government responses to Covid-19 qualify as a violation of democratic standards within the framework of illiberal and authoritarian practices, introducing a dataset covering 144 countries from March 2020 onward. In this article, we provide an overview of the extent to which states violated democratic standards in their response to Covid-19 during 2020. We find no relationship between violations of democratic standards and reported Covid-19 mortality. Illiberal and authoritarian practices in response to the Covid-19 pandemic do not correlate with better public health outcomes. Rather, such crisis-driven violations should be carefully observed as they could signal autocratization.", "doi": "10.1016/j.socscimed.2021.114244", "pmid": "34399291", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0277-9536(21)00576-1"}], "notes": [], "created": "2021-08-17T06:41:22.807Z", "modified": "2022-11-23T08:54:57.436Z"}, {"entity": "publication", "iuid": "9b812d6e85c049a1a63606067812fe0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b812d6e85c049a1a63606067812fe0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b812d6e85c049a1a63606067812fe0e"}}, "title": "Federated Semi-Supervised Multi-Task Learning to Detect COVID-19 and Lungs Segmentation Marking Using Chest Radiography Images and Raspberry Pi Devices: An Internet of Medical Things Application.", "authors": [{"family": "Alam", "given": "Mahbub Ul", "initials": "MU", "orcid": "0000-0002-1101-3793", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d29bbd8d865401b8d0ef481eb80d6e2.json"}}, {"family": "Rahmani", "given": "Rahim", "initials": "R", "orcid": "0000-0001-5924-5457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bf1ae3967524119a9b97042d8ef16b3.json"}}], "type": "journal article", "published": "2021-07-24", "journal": {"title": "Sensors (Basel)", "issn": "1424-8220", "volume": "21", "issue": "15", "issn-l": null}, "abstract": "Internet of Medical Things (IoMT) provides an excellent opportunity to investigate better automatic medical decision support tools with the effective integration of various medical equipment and associated data. This study explores two such medical decision-making tasks, namely COVID-19 detection and lung area segmentation detection, using chest radiography images. We also explore different cutting-edge machine learning techniques, such as federated learning, semi-supervised learning, transfer learning, and multi-task learning to explore the issue. To analyze the applicability of computationally less capable edge devices in the IoMT system, we report the results using Raspberry Pi devices as accuracy, precision, recall, Fscore for COVID-19 detection, and average dice score for lung segmentation detection tasks. We also publish the results obtained through server-centric simulation for comparison. The results show that Raspberry Pi-centric devices provide better performance in lung segmentation detection, and server-centric experiments provide better results in COVID-19 detection. We also discuss the IoMT application-centric settings, utilizing medical data and decision support systems, and posit that such a system could benefit all the stakeholders in the IoMT domain.", "doi": "10.3390/s21155025", "pmid": "34372262", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "s21155025"}], "notes": [], "created": "2021-08-11T14:33:34.731Z", "modified": "2021-08-11T14:33:34.806Z"}, {"entity": "publication", "iuid": "44ae53d507a24f2ba8d79d4ca1bf93da", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44ae53d507a24f2ba8d79d4ca1bf93da.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44ae53d507a24f2ba8d79d4ca1bf93da"}}, "title": "Depression, anxiety and stress among Swedish university students during the second and third waves of COVID-19: A cohort study.", "authors": [{"family": "Johansson", "given": "Fred", "initials": "F", "orcid": "0000-0001-9717-0935", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e23a51cd8dc4d1da5032559b08fddd9.json"}}, {"family": "C\u00f4t\u00e9", "given": "Pierre", "initials": "P"}, {"family": "Hogg-Johnson", "given": "Sheilah", "initials": "S"}, {"family": "Skillgate", "given": "Eva", "initials": "E"}], "type": "journal article", "published": "2021-07-24", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": null, "issue": null, "pages": "14034948211031402"}, "abstract": "This study aims to describe the mean trajectories of depression, anxiety and stress symptoms among Swedish university students before and during the second and third waves of the COVID-19 pandemic.\r\n\r\nWe recruited 1835 participants in September 2020, of whom 81% provided follow-ups in December 2020-January 2021 and 77% provided follow-ups in March-April 2021. The short-form Depression, Anxiety and Stress Scale was used to measure mental health symptoms. Generalized estimating equations were used to estimate the mean differences in symptom levels over the three time periods.\r\n\r\nCompared with September, mean depression was 0.91 points of 21 higher (95% confidence interval (CI) 0.70-1.13) in December 2020-January 2021 and 0.66 points higher (95% CI 0.43-.88) in March-April 2021. Anxiety levels were 0.20 points higher (95% CI 0.05-0.34) in December 2020-January 2021 and 0.17 points higher (95% CI 0.02-0.33) in March-April 2021. Stress levels were 0.21 points higher (95% CI 0.00-0.41) in December 2020-January 2021 and 0.16 points lower (95% CI -0.38 to 0.05) in March-April 2021.\r\n\r\nOur results indicate relatively stable levels of mental health among Swedish university students during the second and third waves of COVID-19 compared with before the second wave. Mean depression symptom scores increased slightly, but the importance of this small increase is uncertain.", "doi": "10.1177/14034948211031402", "pmid": "34304621", "labels": {"Category: Public Health": null, "Type: Journal article": null, "Funder: Forte": null}, "xrefs": [], "notes": [], "created": "2021-08-05T07:01:57.155Z", "modified": "2021-11-18T11:46:25.237Z"}, {"entity": "publication", "iuid": "d1af80ca7b0e42858a06cf240412367a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1af80ca7b0e42858a06cf240412367a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1af80ca7b0e42858a06cf240412367a"}}, "title": "[High correlation between the different measures suggests that mortality is relatively correctly reported in Sweden].", "authors": [{"family": "Kalischer Wellander", "given": "Benjamin", "initials": "B"}, {"family": "L\u00f6tvall", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2021-07-23", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "volume": "118", "issn-l": "0023-7205"}, "abstract": "Infection fatality ratio (IFR) in covid-19 is highly debated in international and Swedish press. In Sweden, three different estimates have been used to estimate mortality, based on statistics either from the Swedish National Board of Health and Welfare, and the Public Health Agency of Sweden, whereas excess mortality calculated by EuroMOMO. Mortality is based on death certificates, which can be accurate or erroneous, but previous analyses have suggested that over- and underdiagnosis usually even out. EuroMOMO on the other hand reports all-cause mortality compared to an estimated baseline. In view of high correlation between the different measures, we suggest that mortality is relatively correctly reported in Sweden. We discuss IFR internationally and in Sweden, and suggest that IFR in the Western world is approximately 0.5-1%. However, these numbers will change over time depending on immunity induced by vaccination efforts, but also the potential spread of new virus variants.", "doi": null, "pmid": "34296754", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "21120"}], "notes": [], "created": "2021-08-05T07:09:48.985Z", "modified": "2021-08-05T07:09:49.008Z"}, {"entity": "publication", "iuid": "a3c910a0c23c46f9bd74172c2e64a432", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3c910a0c23c46f9bd74172c2e64a432.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3c910a0c23c46f9bd74172c2e64a432"}}, "title": "The geography of COVID-19 in Sweden.", "authors": [{"family": "Florida", "given": "Richard", "initials": "R"}, {"family": "Mellander", "given": "Charlotta", "initials": "C", "orcid": "0000-0002-4560-1905", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f4c34f7743b40df8673efcf78c039fc.json"}}], "type": "journal article", "published": "2021-07-23", "journal": {"title": "Ann Reg Sci", "issn": "0570-1864", "pages": "1-26", "issn-l": null}, "abstract": "This paper examines the geographic factors that are associated with the spread of COVID-19 during the first wave in Sweden. We focus particularly on the role of place-based factors versus factors associated with the spread or diffusion of COVID-19 across places. Sweden is a useful case study to examine the interplay of these factors because it did not impose mandatory lockdowns and because there were essentially no regional differences in the pandemic policies or strategies during the first wave of COVID-19. We examine the role of place-based factors like density, age structures and different socioeconomic factors on the geographic variation of COVID-19 cases and on deaths, across both municipalities and neighborhoods. Our findings show that factors associated with diffusion matter more than place-based factors in the geographic incidence of COVID-19 in Sweden. The most significant factor of all is proximity to places with higher levels of infections. COVID-19 is also higher in places that were hit earliest in the outbreak. Of place-based factors, the geographic variation in COVID-19 is most significantly related to the presence of high-risk nursing homes, and only modestly associated with factors like density, population size, income and other socioeconomic characteristics of places.", "doi": "10.1007/s00168-021-01071-0", "pmid": "34316091", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "1071"}, {"db": "pmc", "key": "PMC8299438"}], "notes": [], "created": "2021-08-05T06:47:37.298Z", "modified": "2021-08-05T06:47:37.351Z"}, {"entity": "publication", "iuid": "a5388cc81d2f4c0288d874cf43668310", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a5388cc81d2f4c0288d874cf43668310.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a5388cc81d2f4c0288d874cf43668310"}}, "title": "Housing, sanitation and living conditions affecting SARS-CoV-2 prevention interventions in 54 African countries.", "authors": [{"family": "Brewer", "given": "Timothy F", "initials": "TF", "orcid": "0000-0002-5615-1639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6e0f3db6e834dc3b13f7bb5920f588c.json"}}, {"family": "Zhang", "given": "Mary", "initials": "M", "orcid": "0000-0003-2534-3811", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a481992f82c74686845a5043cad02382.json"}}, {"family": "Gordon", "given": "David", "initials": "D"}, {"family": "Chung", "given": "Roger Yat-Nork", "initials": "RY"}, {"family": "Dejene", "given": "Negussie", "initials": "N"}, {"family": "Fonta", "given": "Cynthia L", "initials": "CL"}, {"family": "Grieve", "given": "Tigist", "initials": "T"}, {"family": "Haller\u00f6d", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Harris", "given": "Richard", "initials": "R"}, {"family": "Lanau", "given": "Alba", "initials": "A", "orcid": "0000-0001-6226-8545", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/da7a6d18caf847e3b424c6dbfd87640b.json"}}, {"family": "Leibbrandt", "given": "Murray", "initials": "M"}, {"family": "Mekonen", "given": "Yehualashet", "initials": "Y"}, {"family": "Muguni", "given": "Bongai", "initials": "B"}, {"family": "Najera", "given": "Hector", "initials": "H"}, {"family": "Nandy", "given": "Shailen", "initials": "S"}, {"family": "Heymann", "given": "S Jody", "initials": "SJ"}], "type": "journal article", "published": "2021-07-23", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": "149", "pages": "e183", "issn-l": null}, "abstract": "The feasibility of non-pharmacological public health interventions (NPIs) such as physical distancing or isolation at home to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in low-resource countries is unknown. Household survey data from 54 African countries were used to investigate the feasibility of SARS-CoV-2 NPIs in low-resource settings. Across the 54 countries, approximately 718 million people lived in households with \u2a7e6 individuals at home (median percentage of at-risk households 56% (95% confidence interval (CI), 51% to 60%)). Approximately 283 million people lived in households where \u2a7e3 people slept in a single room (median percentage of at-risk households 15% (95% CI, 13% to 19%)). An estimated 890 million Africans lack on-site water (71% (95% CI, 62% to 80%)), while 700 million people lacked in-home soap/washing facilities (56% (95% CI, 42% to 73%)). The median percentage of people without a refrigerator in the home was 79% (95% CI, 67% to 88%), while 45% (95% CI, 39% to 52%) shared toilet facilities with other households. Individuals in low-resource settings have substantial obstacles to implementing NPIs for mitigating SARS-CoV-2 transmission. These populations urgently need to be prioritised for coronavirus disease 2019 vaccination to prevent disease and to contain the global pandemic.", "doi": "10.1017/S0950268821001734", "pmid": "35852445", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0950268821001734"}, {"db": "pmc", "key": "PMC8367861"}], "notes": [], "created": "2022-08-12T08:50:35.543Z", "modified": "2022-08-12T08:51:09.009Z"}, {"entity": "publication", "iuid": "1bab0821eb174292b14bebc89e264da4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1bab0821eb174292b14bebc89e264da4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1bab0821eb174292b14bebc89e264da4"}}, "title": "Hofbauer cells and coronavirus disease 2019 (COVID-19) in pregnancy: Molecular pathology analysis of villous macrophages, endothelial cells, and placental findings from 22 placentas infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with and without fetal transmission.", "authors": [{"family": "Schwartz", "given": "David A", "initials": "DA"}, {"family": "Baldewijns", "given": "Marcella", "initials": "M"}, {"family": "Benachi", "given": "Alexandra", "initials": "A"}, {"family": "Bugatti", "given": "Mattia", "initials": "M"}, {"family": "Bulfamante", "given": "Gaetano", "initials": "G"}, {"family": "Cheng", "given": "Ke", "initials": "K"}, {"family": "Collins", "given": "Rebecca R J", "initials": "RRJ"}, {"family": "Debelenko", "given": "Larisa", "initials": "L"}, {"family": "De Luca", "given": "Dani\u00e8le", "initials": "D"}, {"family": "Facchetti", "given": "Fabio", "initials": "F"}, {"family": "Fitzgerald", "given": "Brendan", "initials": "B"}, {"family": "Levitan", "given": "Daniel", "initials": "D"}, {"family": "Linn", "given": "Rebecca L", "initials": "RL"}, {"family": "Marcelis", "given": "Lukas", "initials": "L"}, {"family": "Morotti", "given": "Denise", "initials": "D"}, {"family": "Morotti", "given": "Raffaella", "initials": "R"}, {"family": "Patan\u00e8", "given": "Luisa", "initials": "L"}, {"family": "Prevot", "given": "Sophie", "initials": "S"}, {"family": "Pulinx", "given": "Bianca", "initials": "B"}, {"family": "Saad", "given": "Ali G", "initials": "AG"}, {"family": "Schoenmakers", "given": "Sam", "initials": "S"}, {"family": "Strybol", "given": "David", "initials": "D"}, {"family": "Thomas", "given": "Kristen", "initials": "K"}, {"family": "Tosi", "given": "Delfina", "initials": "D"}, {"family": "Toto", "given": "Valentina", "initials": "V"}, {"family": "van der Meeren", "given": "Lotte E", "initials": "LE"}, {"family": "Verdijk", "given": "Robert M", "initials": "RM"}, {"family": "Vivanti", "given": "Alexandre J", "initials": "AJ"}, {"family": "Zaigham", "given": "Mehreen", "initials": "M"}], "type": "journal article", "published": "2021-07-23", "journal": {"title": "Arch Pathol Lab Med", "issn": "1543-2165", "issn-l": null}, "abstract": "- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can undergo maternal-fetal transmission, heightening interest in the placental pathology findings from this infection. Transplacental SARS-CoV-2 transmission is typically accompanied by chronic histiocytic intervillositis together with necrosis and positivity of syncytiotrophoblast for SARSCoV-2. Hofbauer cells are placental macrophages that have been involved in viral diseases including HIV and Zika virus, but their involvement in SARS-CoV-2 in unknown.\n\n- To determine whether SARS-CoV-2 can extend beyond the syncytiotrophoblast to enter Hofbauer cells, endothelium and other villous stromal cells in infected placentas of liveborn and stillborn infants.\n\n- Case-based retrospective analysis by 29 perinatal and molecular pathology specialists of placental findings from a preselected cohort of 22 SARS-CoV-2-infected placentas delivered to pregnant women testing positive for SARS-CoV-2 from 7 countries. Molecular pathology methods were used to investigate viral involvement of Hofbauer cells, villous capillary endothelium, syncytiotrophoblast and other fetal-derived cells.\n\n- Chronic histiocytic intervillositis and trophoblast necrosis was present in all 22 placentas (100%). SARS-CoV-2 was identified in Hofbauer cells from 4/22 placentas (18%). Villous capillary endothelial staining was positive in 2/22 cases (9%), both of which also had viral positivity in Hofbauer cells. Syncytiotrophoblast staining occurred in 21/22 placentas (95%). Hofbauer cell hyperplasia was present in 3/22 placentas (14%). In the 7 cases having documented transplacental infection of the fetus, 2 occurred in placentas with Hofbauer cell staining positive for SARS-CoV-2.\n\n- SARS-CoV-2 can extend beyond the trophoblast into the villous stroma, involving Hofbauer cells and capillary endothelial cells, in a small number of infected placentas. Most cases of SARS-CoV-2 transplacental fetal infection occur without Hofbauer cell involvement.", "doi": "10.5858/arpa.2021-0296-SA", "pmid": "34297794", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "468285"}], "notes": [], "created": "2021-08-05T07:09:11.883Z", "modified": "2021-08-05T07:09:11.909Z"}, {"entity": "publication", "iuid": "c38cd02818614d4db2930bfdc6e6e978", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c38cd02818614d4db2930bfdc6e6e978.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c38cd02818614d4db2930bfdc6e6e978"}}, "title": "COVID-19 in patients with CLL: improved survival outcomes and update on management strategies.", "authors": [{"family": "Roeker", "given": "Lindsey Elizabeth", "initials": "LE", "orcid": "0000-0002-3806-059X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d78144759e5240fda88869040bbb3405.json"}}, {"family": "Eyre", "given": "Toby Andrew", "initials": "TA", "orcid": "0000-0002-6631-9749", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d824fbb04d640d1b07bd88c1a09051c.json"}}, {"family": "Thompson", "given": "Meghan C", "initials": "MC"}, {"family": "Lamanna", "given": "Nicole", "initials": "N"}, {"family": "Coltoff", "given": "Alexander", "initials": "A"}, {"family": "Davids", "given": "Matthew S", "initials": "MS"}, {"family": "Baker", "given": "Peter", "initials": "P"}, {"family": "Leslie", "given": "Lori A", "initials": "LA"}, {"family": "Rogers", "given": "Kerry A", "initials": "KA", "orcid": "0000-0001-5748-7874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7dca0a2b81624be29144cc75eee2fe3f.json"}}, {"family": "Allan", "given": "John N", "initials": "JN", "orcid": "0000-0002-2088-0899", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f6a405964541f09452612c83538d89.json"}}, {"family": "Cordoba", "given": "Raul", "initials": "R", "orcid": "0000-0002-7654-8836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14e78d427a5a42c4aa2f063439846f7b.json"}}, {"family": "Lopez-Garcia", "given": "Alberto", "initials": "A", "orcid": "0000-0002-5354-5261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c785356a67e4cbb9835fe9ce04a6153.json"}}, {"family": "Antic", "given": "Darko", "initials": "D"}, {"family": "Pagel", "given": "John M", "initials": "JM"}, {"family": "Martinez-Calle", "given": "Nicol\u00e1s", "initials": "N", "orcid": "0000-0002-5184-9464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65797f47ca614ab88d8a11ec1ccf7207.json"}}, {"family": "Garcia-Marco", "given": "Jose Antonio", "initials": "JA", "orcid": "0000-0002-8993-5982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae24000421684dd4b672a42c0175db23.json"}}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jos\u00e9-\u00c1ngel", "initials": "J\u00c1", "orcid": "0000-0003-4550-757X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d071af0c0a14dc695bcda29033b49ce.json"}}, {"family": "Miras", "given": "Fatima", "initials": "F", "orcid": "0000-0001-5096-3145", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d86c6b42a4aa432195768fca2c6aa250.json"}}, {"family": "Coombs", "given": "Catherine C", "initials": "CC"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Seddon", "given": "Amanda N", "initials": "AN"}, {"family": "L\u00f3pez-Jim\u00e9nez", "given": "Javier", "initials": "J", "orcid": "0000-0002-2969-3002", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49c7283585d74f94898db807e53654db.json"}}, {"family": "Wilson", "given": "Matthew R", "initials": "MR", "orcid": "0000-0001-5423-3270", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc62369e0fb6429f94baf3619752c379.json"}}, {"family": "El-Sharkawi", "given": "Dima", "initials": "D", "orcid": "0000-0002-2752-5814", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fedd8b1cbb8c4e7a8a4a1840484d1289.json"}}, {"family": "Wojenski", "given": "Daniel", "initials": "D"}, {"family": "Ma", "given": "Shuo", "initials": "S"}, {"family": "Munir", "given": "Talha", "initials": "T"}, {"family": "Valenciano", "given": "Susana", "initials": "S"}, {"family": "Seymour", "given": "Erlene", "initials": "E"}, {"family": "Barr", "given": "Paul M", "initials": "PM", "orcid": "0000-0002-9733-401X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0ab119d82bf451db7cf78e7869c7ceb.json"}}, {"family": "Pu", "given": "Jeffrey J", "initials": "JJ", "orcid": "0000-0001-7498-3159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46d92e703b1e4634893c554254312a3f.json"}}, {"family": "Patten", "given": "Piers Em", "initials": "PE", "orcid": "0000-0003-3320-3034", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/245eaf4074b640499338cdf50ba61346.json"}}, {"family": "Perini", "given": "Guilherme Fleury", "initials": "GF"}, {"family": "Huntington", "given": "Scott F", "initials": "SF", "orcid": "0000-0001-7071-6475", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f9ee32a2ca0408697f8d8c1dfb185d8.json"}}, {"family": "Parry", "given": "Helen", "initials": "H", "orcid": "0000-0002-9707-8167", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5e7db11dc49496cac185fa8f9c99927.json"}}, {"family": "Sundaram", "given": "Suchitra", "initials": "S"}, {"family": "Skarbnik", "given": "Alan P", "initials": "AP"}, {"family": "Kamdar", "given": "Manali", "initials": "M"}, {"family": "Jacobs", "given": "Ryan W", "initials": "RW"}, {"family": "Walter", "given": "Harriet Sarah", "initials": "HS", "orcid": "0000-0003-2618-711X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76bd37449eda49b28de194fe74e9f289.json"}}, {"family": "Walewska", "given": "Renata", "initials": "R"}, {"family": "Broom", "given": "Angus", "initials": "A"}, {"family": "Lebowitz", "given": "Sonia", "initials": "S"}, {"family": "Isaac", "given": "Krista", "initials": "K", "orcid": "0000-0002-0234-139X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f2b9b13aac204070b5d7f7c3f69c123a.json"}}, {"family": "Portell", "given": "Craig A", "initials": "CA"}, {"family": "Ahn", "given": "Inhye E", "initials": "IE"}, {"family": "Ujjani", "given": "Chaitra", "initials": "C"}, {"family": "Shadman", "given": "Mazyar", "initials": "M", "orcid": "0000-0002-3365-6562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7856504963b74fbd85d7a62929233ed4.json"}}, {"family": "Sk\u00e5nland", "given": "Sigrid S", "initials": "SS"}, {"family": "Chong", "given": "Elise A", "initials": "EA"}, {"family": "Mato", "given": "Anthony R", "initials": "AR"}], "type": "journal article", "published": "2021-07-23", "journal": {"title": "Blood", "issn": "1528-0020", "issn-l": null}, "abstract": null, "doi": "10.1182/blood.2021011841", "pmid": "34297826", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "476453"}, {"db": "pmc", "key": "PMC8313815"}], "notes": [], "created": "2021-08-05T07:08:33.175Z", "modified": "2021-08-05T07:10:37.957Z"}, {"entity": "publication", "iuid": "3eb160a2384b417f8944066124b7e76b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3eb160a2384b417f8944066124b7e76b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3eb160a2384b417f8944066124b7e76b"}}, "title": "Anxiety, Compassion and Pride. How Emotions Elicited by the Government's Handling of Covid-19 Influences Health-Promoting Behavior.", "authors": [{"family": "Renstr\u00f6m", "given": "Emma A", "initials": "EA", "orcid": "0000-0001-6593-2464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c969b46ee25b4276916587537076440c.json"}}, {"family": "B\u00e4ck", "given": "Hanna", "initials": "H", "orcid": "0000-0002-0296-9419", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8afb5218cb145e99b138ef5b8d29f76.json"}}], "type": "journal article", "published": "2021-07-23", "journal": {"title": "Psychol Belg", "issn": "2054-670X", "volume": "61", "issue": "1", "pages": "224-237", "issn-l": null}, "abstract": "This article explores how emotions connected to the Government's handling of the Covid-19 outbreak in Sweden relates to behaviors to stop the spread of the virus, and which emotions functions as mediators in this relationship. The Swedish approach to handling the outbreak greatly differed from how many other Western European countries handled the situation and thus makes an important case to study. In a large representative survey (N = 2449), we found that satisfaction with how the Government handled the situation was related to more positive and less negative emotions. Anxiety, compassion and pride mediated the effect of satisfaction on compliance with the national recommendations such that anxiety and compassion increased compliance, while pride decreased it. Importantly though, satisfaction increased compassion and pride, but only compassion led to more compliant behaviors. In fact, satisfaction was indirectly related to less compliant behaviors via anxiety and pride. Shame mediated the effect on the tendency to wear face masks, a behavior that was explicitly not endorsed by the Swedish Public Health Agency. We speculate if the face mask, which was intensely debated, became a politicized symbol of dissatisfaction with the Swedish approach. In sum, it seems that individuals who were dissatisfied with how the government handled the Covid-19 outbreak were in fact engaging more in health-promotional behaviors to stop the spread of the virus.", "doi": "10.5334/pb.1053", "pmid": "34394949", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8300590"}], "notes": [], "created": "2021-08-17T06:43:53.775Z", "modified": "2021-08-17T06:43:53.850Z"}, {"entity": "publication", "iuid": "3023575e9ca747a4b7cb37e51b78464c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3023575e9ca747a4b7cb37e51b78464c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3023575e9ca747a4b7cb37e51b78464c"}}, "title": "Post-SARS-CoV-2-vaccination cerebral venous sinus thrombosis: an analysis of cases notified to the European Medicines Agency.", "authors": [{"family": "Krzywicka", "given": "Katarzyna", "initials": "K"}, {"family": "Heldner", "given": "Mirjam R", "initials": "MR", "orcid": "0000-0002-3594-2159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8280f8c6ea3a486abae8acc6aa491985.json"}}, {"family": "S\u00e1nchez van Kammen", "given": "Mayte", "initials": "M"}, {"family": "van Haaps", "given": "Thijs", "initials": "T"}, {"family": "Hiltunen", "given": "Sini", "initials": "S"}, {"family": "Silvis", "given": "Suzanne M", "initials": "SM"}, {"family": "Levi", "given": "Marcel", "initials": "M", "orcid": "0000-0002-2212-5299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d684119a7b2a42309d674f7094b81adc.json"}}, {"family": "Kremer Hovinga", "given": "Johanna A", "initials": "JA"}, {"family": "Jood", "given": "Katarina", "initials": "K"}, {"family": "Lindgren", "given": "Erik", "initials": "E"}, {"family": "Tatlisumak", "given": "Turgut", "initials": "T", "orcid": "0000-0002-2430-8988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03cddf3042b8470eaa083b6fa1e9e4bb.json"}}, {"family": "Putaala", "given": "Jukka", "initials": "J"}, {"family": "Aguiar de Sousa", "given": "Diana", "initials": "D", "orcid": "0000-0002-6702-7924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cc3515119a247859fe1fea025f703ef.json"}}, {"family": "Middeldorp", "given": "Saskia", "initials": "S", "orcid": "0000-0002-1006-6420", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03eef1eda4d0467084c5b8459e705cae.json"}}, {"family": "Arnold", "given": "Marcel", "initials": "M", "orcid": "0000-0002-4274-4644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10447e916b9b49f294e79a590139b9e3.json"}}, {"family": "Coutinho", "given": "Jonathan M", "initials": "JM", "orcid": "0000-0002-8284-982X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98cadafdcc044688bab25a3d7f9562b9.json"}}, {"family": "Ferro", "given": "Jos\u00e9 M", "initials": "JM", "orcid": "0000-0002-2343-9097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c8285bcf71c4ed1aa7b57a13c5cb70a.json"}}], "type": "journal article", "published": "2021-07-22", "journal": {"title": "Eur J Neurol", "issn": "1468-1331", "issn-l": null}, "abstract": "Cerebral venous sinus thrombosis (CVST) has been described after vaccination against SARS-CoV-2. The clinical characteristics of 213 post-vaccination CVST cases notified to the European Medicines Agency are reported.\n\nData on adverse drug reactions after SARS-CoV-2 vaccination notified until 8 April 2021 under the Medical Dictionary for Regulatory Activities Term 'Central nervous system vascular disorders' were obtained from the EudraVigilance database. Post-vaccination CVST was compared with 100 European patients with CVST from before the COVID-19 pandemic derived from the International CVST Consortium.\n\nIn all, 213 CVST cases were identified: 187 after AstraZeneca/Oxford (ChAdOx1 nCov-19) vaccination and 26 after a messenger RNA (mRNA) vaccination (25 with Pfizer/BioNTech, BNT162b2, and one with Moderna, mRNA-1273). Thrombocytopenia was reported in 107/187 CVST cases (57%, 95% confidence interval [CI] 50%-64%) in the ChAdOx1 nCov-19 group, in none in the mRNA vaccine group (0%, 95% CI 0%-13%) and in 7/100 (7%, 95% CI 3%-14%) in the pre-COVID-19 group. In the ChAdOx1 nCov-19 group, 39 (21%) reported COVID-19 polymerase chain reaction tests were performed within 30 days of CVST symptom onset, and all were negative. Of the 117 patients with a reported outcome in the ChAdOx1 nCov-19 group, 44 (38%, 95% CI 29%-47%) had died, compared to 2/10 (20%, 95% CI 6%-51%) in the mRNA vaccine group and 3/100 (3%, 95% CI 1%-8%) in the pre-COVID-19 group. Mortality amongst patients with thrombocytopenia in the ChAdOx1 nCov-19 group was 49% (95% CI 39%-60%).\n\nCerebral venous sinus thrombosis occurring after ChAdOx1 nCov-19 vaccination has a clinical profile distinct from CVST unrelated to vaccination. Only CVST after ChAdOx1 nCov-19 vaccination was associated with thrombocytopenia.", "doi": "10.1111/ene.15029", "pmid": "34293217", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-08-05T11:08:35.032Z", "modified": "2021-08-05T11:09:14.447Z"}, {"entity": "publication", "iuid": "c43b6b0e6a3b47f38b572fff9c87d349", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c43b6b0e6a3b47f38b572fff9c87d349.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c43b6b0e6a3b47f38b572fff9c87d349"}}, "title": "Physical activity and the risk of SARS-CoV-2 infection, severe COVID-19 illness and COVID-19 related mortality in South Korea: a nationwide cohort study.", "authors": [{"family": "Lee", "given": "Seung Won", "initials": "SW", "orcid": "0000-0001-5632-5208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b38b67e00dbf4d80a72a30152b99c0a3.json"}}, {"family": "Lee", "given": "Jinhee", "initials": "J"}, {"family": "Moon", "given": "Sung Yong", "initials": "SY"}, {"family": "Jin", "given": "Hyun Young", "initials": "HY"}, {"family": "Yang", "given": "Jee Myung", "initials": "JM"}, {"family": "Ogino", "given": "Shuji", "initials": "S"}, {"family": "Song", "given": "Mingyang", "initials": "M"}, {"family": "Hong", "given": "Sung Hwi", "initials": "SH"}, {"family": "Abou Ghayda", "given": "Ramy", "initials": "R"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Jacob", "given": "Louis", "initials": "L"}, {"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Smith", "given": "Lee", "initials": "L"}, {"family": "Giovannucci", "given": "Edward", "initials": "E"}, {"family": "Lee", "given": "I-Min", "initials": "IM", "orcid": "0000-0002-1083-6907", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d9a901889fd4ddabefdbab40fbaf1ae.json"}}, {"family": "Lee", "given": "Dong Hoon", "initials": "DH"}, {"family": "Lee", "given": "Keum Hwa", "initials": "KH"}, {"family": "Shin", "given": "Youn Ho", "initials": "YH"}, {"family": "Kim", "given": "So Young", "initials": "SY"}, {"family": "Kim", "given": "Min Seo", "initials": "MS", "orcid": "0000-0003-2115-7835", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3078a38bd45044b3ac5b32d0eb09fbda.json"}}, {"family": "Won", "given": "Hong-Hee", "initials": "HH"}, {"family": "Ekelund", "given": "Ulf", "initials": "U"}, {"family": "Shin", "given": "Jae Il", "initials": "JI"}, {"family": "Yon", "given": "Dong Keon", "initials": "DK", "orcid": "0000-0003-1628-9948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/747eb5856d2e444fbc1e5aaef8d3aa40.json"}}], "type": "journal article", "published": "2021-07-22", "journal": {"title": "Br J Sports Med", "issn": "1473-0480", "issn-l": null}, "abstract": "To determine the potential associations between physical activity and risk of SARS-CoV-2 infection, severe illness from COVID-19 and COVID-19 related death using a nationwide cohort from South Korea.\n\nData regarding 212 768 Korean adults (age \u226520 years), who tested for SARS-CoV-2, from 1 January 2020 to 30 May 2020, were obtained from the National Health Insurance Service of South Korea and further linked with the national general health examination from 1 January 2018 to 31 December 2019 to assess physical activity levels. SARS-CoV-2 positivity, severe COVID-19 illness and COVID-19 related death were the main outcomes. The observation period was between 1 January 2020 and 31 July 2020.\n\nOut of 76 395 participants who completed the general health examination and were tested for SARS-CoV-2, 2295 (3.0%) were positive for SARS-CoV-2, 446 (0.58%) had severe illness from COVID-19 and 45 (0.059%) died from COVID-19. Adults who engaged in both aerobic and muscle strengthening activities according to the 2018 physical activity guidelines had a lower risk of SARS-CoV-2 infection (2.6% vs 3.1%; adjusted relative risk (aRR), 0.85; 95% CI 0.72 to 0.96), severe COVID-19 illness (0.35% vs 0.66%; aRR 0.42; 95% CI 0.19 to 0.91) and COVID-19 related death (0.02% vs 0.08%; aRR 0.24; 95% CI 0.05 to 0.99) than those who engaged in insufficient aerobic and muscle strengthening activities. Furthermore, the recommended range of metabolic equivalent task (MET; 500-1000 MET min/week) was associated with the maximum beneficial effect size for reduced risk of SARS-CoV-2 infection (aRR 0.78; 95% CI 0.66 to 0.92), severe COVID-19 illness (aRR 0.62; 95% CI 0.43 to 0.90) and COVID-19 related death (aRR 0.17; 95% CI 0.07 to 0.98). Similar patterns of association were observed in different sensitivity analyses.\n\nAdults who engaged in the recommended levels of physical activity were associated with a decreased likelihood of SARS-CoV-2 infection, severe COVID-19 illness and COVID-19 related death. Our findings suggest that engaging in physical activity has substantial public health value and demonstrates potential benefits to combat COVID-19.", "doi": "10.1136/bjsports-2021-104203", "pmid": "34301715", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bjsports-2021-104203"}, {"db": "pmc", "key": "PMC8300550"}], "notes": [], "created": "2021-08-05T07:06:44.215Z", "modified": "2021-08-05T07:06:45.565Z"}, {"entity": "publication", "iuid": "1a006b8339e64c42b03e1e4d6206b370", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1a006b8339e64c42b03e1e4d6206b370.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1a006b8339e64c42b03e1e4d6206b370"}}, "title": "Marine Sulfated Polysaccharides as Promising Antiviral Agents: A Comprehensive Report and Modeling Study Focusing on SARS CoV-2.", "authors": [{"family": "Salih", "given": "Abdalla E M", "initials": "AEM"}, {"family": "Thissera", "given": "Bathini", "initials": "B", "orcid": "0000-0002-0998-4187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b46765518df488e9f7433b162103dde.json"}}, {"family": "Yaseen", "given": "Mohammed", "initials": "M", "orcid": "0000-0002-2460-1893", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b57b297419fe47188812beeaffc62cf0.json"}}, {"family": "Hassane", "given": "Ahmed S I", "initials": "ASI"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}, {"family": "Sayed", "given": "Ahmed M", "initials": "AM", "orcid": "0000-0002-1442-183X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/013ee0ba73bb4d7f87fd285c65e49725.json"}}, {"family": "Rateb", "given": "Mostafa E", "initials": "ME", "orcid": "0000-0003-4043-2687", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59c7eb5f74ca45f695bffb7960cbedcc.json"}}], "type": "journal article", "published": "2021-07-22", "journal": {"title": "Mar Drugs", "issn": "1660-3397", "volume": "19", "issue": "8", "pages": "406", "issn-l": null}, "abstract": "SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) is a novel coronavirus strain that emerged at the end of 2019, causing millions of deaths so far. Despite enormous efforts being made through various drug discovery campaigns, there is still a desperate need for treatments with high efficacy and selectivity. Recently, marine sulfated polysaccharides (MSPs) have earned significant attention and are widely examined against many viral infections. This article attempted to produce a comprehensive report about MSPs from different marine sources alongside their antiviral effects against various viral species covering the last 25 years of research articles. Additionally, these reported MSPs were subjected to molecular docking and dynamic simulation experiments to ascertain potential interactions with both the receptor-binding domain (RBD) of SARS CoV-2's spike protein (S-protein) and human angiotensin-converting enzyme-2 (ACE2). The possible binding sites on both S-protein's RBD and ACE2 were determined based on how they bind to heparin, which has been reported to exhibit significant antiviral activity against SARS CoV-2 through binding to RBD, preventing the virus from affecting ACE2. Moreover, our modeling results illustrate that heparin can also bind to and block ACE2, acting as a competitor and protective agent against SARS CoV-2 infection. Nine of the investigated MSPs candidates exhibited promising results, taking into consideration the newly emerged SARS CoV-2 variants, of which five were not previously reported to exert antiviral activity against SARS CoV-2, including sulfated galactofucan (1), sulfated polymannuroguluronate (SPMG) (2), sulfated mannan (3), sulfated heterorhamnan (8), and chondroitin sulfate E (CS-E) (9). These results shed light on the importance of sulfated polysaccharides as potential SARS-CoV-2 inhibitors.", "doi": "10.3390/md19080406", "pmid": "34436245", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "md19080406"}, {"db": "pmc", "key": "PMC8401819"}], "notes": [], "created": "2021-08-27T09:35:33.179Z", "modified": "2021-09-01T07:17:08.967Z"}, {"entity": "publication", "iuid": "5f137f6991f648d0876bfdbe5a44aab0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f137f6991f648d0876bfdbe5a44aab0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f137f6991f648d0876bfdbe5a44aab0"}}, "title": "Ultrametric diffusion equation on energy landscape to model disease spread in hierarchic socially clustered population.", "authors": [{"family": "Khrennikov", "given": "Andrei", "initials": "A"}], "type": "journal article", "published": "2021-07-21", "journal": {"title": "Physica A", "issn": "0378-4371", "pages": "126284", "issn-l": null}, "abstract": "We present a new mathematical model of disease spread reflecting some specialties of the covid-19 epidemic by elevating the role of hierarchic social clustering of population. The model can be used to explain slower approaching herd immunity, e.g., in Sweden, than it was predicted by a variety of other mathematical models and was expected by epidemiologists; see graphs Fig. 1,2. The hierarchic structure of social clusters is mathematically modeled with ultrametric spaces having treelike geometry. To simplify mathematics, we consider trees with the constant number of branches leaving each vertex. Such trees are endowed with an algebraic structure, these are p > 1 -adic number fields. We apply theory of the p -adic diffusion equation to describe a virus spread in hierarchically clustered population. This equation has applications to statistical physics and microbiology for modeling pdynamics on energy landscapes. To move from one social cluster (valley) to another, a virus (its carrier) should cross a social barrier between them. The magnitude of a barrier depends on the number of social hierarchy's levels composing this barrier. We consider linearly increasing barriers. A virus spreads rather easily inside a social cluster (say working collective), but jumps to other clusters are constrained by social barriers. This behavior matches with the covid-19 epidemic, with its cluster spreading structure. Our model differs crucially from the standard mathematical models of spread of disease, such as the SIR-model; in particular, by notion of the probability to be infected (at time in a social cluster t ). We present socio-medical specialties of the covid-19 epidemic supporting our model.C", "doi": "10.1016/j.physa.2021.126284", "pmid": "34312573", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0378-4371(21)00557-4"}, {"db": "pmc", "key": "PMC8294751"}], "notes": [], "created": "2021-08-05T06:50:47.154Z", "modified": "2021-08-05T06:50:47.181Z"}, {"entity": "publication", "iuid": "ee384aaba0c94162879c0d22e3f0f263", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee384aaba0c94162879c0d22e3f0f263.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee384aaba0c94162879c0d22e3f0f263"}}, "title": "Impact of the COVID-19 pandemic on the management of chronic noninfectious respiratory diseases.", "authors": [{"family": "Tiotiu", "given": "Angelica", "initials": "A", "orcid": "0000-0002-8038-9559", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ee2c77aeb734a9dbb4746210468f2d5.json"}}, {"family": "Chong Neto", "given": "Herberto", "initials": "H"}, {"family": "Bikov", "given": "Andras", "initials": "A"}, {"family": "Kowal", "given": "Krzysztof", "initials": "K"}, {"family": "Steiropoulos", "given": "Paschalis", "initials": "P"}, {"family": "Labor", "given": "Marina", "initials": "M", "orcid": "0000-0001-5216-8129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9a750b29a224b7bb07d535004dfdf15.json"}}, {"family": "Cherrez-Ojeda", "given": "Ivan", "initials": "I", "orcid": "0000-0002-1610-239X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ee022e7bd4d4b80baa3c24aa98c0b92.json"}}, {"family": "Badellino", "given": "Hector", "initials": "H"}, {"family": "Emelyanov", "given": "Alexander", "initials": "A"}, {"family": "Garcia", "given": "Rocio", "initials": "R"}, {"family": "Guidos", "given": "Guillermo", "initials": "G", "orcid": "0000-0003-1675-3894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9446a00028a248e49be76f868ee7c701.json"}}], "type": "journal article", "published": "2021-07-21", "journal": {"title": "Expert Rev Respir Med", "issn": "1747-6356", "pages": "1-14", "issn-l": null}, "abstract": "Introduction: The COVID-19 pandemic has challenged health care across the world, not just by the severity of the disease and the high mortality rate but also by the consequences on the management of the patients with chronic diseases.Areas covered: This review summarizes the most up-to-date published data regarding the impact of COVID-19 on the management and outcomes of patients with chronic noninfectious respiratory illnesses including obstructive sleep apnea, asthma, chronic obstructive pulmonary disease, bronchiectasis, interstitial and pulmonary vascular diseases, and lung cancer.Expert opinion: Most of chronic respiratory diseases (except asthma and cystic fibrosis) are associated with more severe COVID-19 and poor outcomes but the mechanisms involved are not yet identified. The therapeutic management of the patients with chronic respiratory diseases and COVID-19 is similar to the other patients but the post-recovery course could be worse in this population and followed by the development of pulmonary fibrosis, bronchiectasis, and pulmonary hypertension. The pandemic highly impacted our usual medical activities by limiting the access to several diagnosis procedures, the necessity to develop new methods for the monitoring of the disease and adapt the therapeutic strategies. The long-term consequences of all these changes are still unknown.", "doi": "10.1080/17476348.2021.1951707", "pmid": "34253132", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:35:18.427Z", "modified": "2021-08-06T07:35:30.520Z"}, {"entity": "publication", "iuid": "dde1dda8dae541878726006521406dfd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dde1dda8dae541878726006521406dfd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dde1dda8dae541878726006521406dfd"}}, "title": "Dapagliflozin in patients with cardiometabolic risk factors hospitalised with COVID-19 (DARE-19): a randomised, double-blind, placebo-controlled, phase 3 trial.", "authors": [{"family": "Kosiborod", "given": "Mikhail N", "initials": "MN"}, {"family": "Esterline", "given": "Russell", "initials": "R"}, {"family": "Furtado", "given": "Remo H M", "initials": "RHM"}, {"family": "Oscarsson", "given": "Jan", "initials": "J"}, {"family": "Gasparyan", "given": "Samvel B", "initials": "SB"}, {"family": "Koch", "given": "Gary G", "initials": "GG"}, {"family": "Martinez", "given": "Felipe", "initials": "F"}, {"family": "Mukhtar", "given": "Omar", "initials": "O"}, {"family": "Verma", "given": "Subodh", "initials": "S"}, {"family": "Chopra", "given": "Vijay", "initials": "V"}, {"family": "Buenconsejo", "given": "Joan", "initials": "J"}, {"family": "Langkilde", "given": "Anna Maria", "initials": "AM"}, {"family": "Ambery", "given": "Philip", "initials": "P"}, {"family": "Tang", "given": "Fengming", "initials": "F"}, {"family": "Gosch", "given": "Kensey", "initials": "K"}, {"family": "Windsor", "given": "Sheryl L", "initials": "SL"}, {"family": "Akin", "given": "Emily E", "initials": "EE"}, {"family": "Soares", "given": "Ronaldo V P", "initials": "RVP"}, {"family": "Moia", "given": "Diogo D F", "initials": "DDF"}, {"family": "Aboudara", "given": "Matthew", "initials": "M"}, {"family": "Hoffmann Filho", "given": "Conrado Roberto", "initials": "CR"}, {"family": "Feitosa", "given": "Audes D M", "initials": "ADM"}, {"family": "Fonseca", "given": "Alberto", "initials": "A"}, {"family": "Garla", "given": "Vishnu", "initials": "V"}, {"family": "Gordon", "given": "Robert A", "initials": "RA"}, {"family": "Javaheri", "given": "Ali", "initials": "A"}, {"family": "Jaeger", "given": "Cristiano P", "initials": "CP"}, {"family": "Leaes", "given": "Paulo E", "initials": "PE"}, {"family": "Nassif", "given": "Michael", "initials": "M"}, {"family": "Pursley", "given": "Michael", "initials": "M"}, {"family": "Silveira", "given": "Fabio Serra", "initials": "FS"}, {"family": "Barroso", "given": "Weimar Kunz Sebba", "initials": "WKS"}, {"family": "Lazcano Soto", "given": "Jos\u00e9 Roberto", "initials": "JR"}, {"family": "Nigro Maia", "given": "Lilia", "initials": "L"}, {"family": "Berwanger", "given": "Otavio", "initials": "O"}], "type": "journal article", "published": "2021-07-21", "journal": {"title": "Lancet Diabetes Endocrinol", "issn": "2213-8595", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "COVID-19 can lead to multiorgan failure. Dapagliflozin, a SGLT2 inhibitor, has significant protective benefits for the heart and kidney. We aimed to see whether this agent might provide organ protection in patients with COVID-19 by affecting processes dysregulated during acute illness.\r\n\r\nDARE-19 was a randomised, double-blind, placebo-controlled trial of patients hospitalised with COVID-19 and with at least one cardiometabolic risk factor (ie, hypertension, type 2 diabetes, atherosclerotic cardiovascular disease, heart failure, and chronic kidney disease). Patients critically ill at screening were excluded. Patients were randomly assigned 1:1 to dapagliflozin (10 mg daily orally) or matched placebo for 30 days. Dual primary outcomes were assessed in the intention-to-treat population: the outcome of prevention (time to new or worsened organ dysfunction or death), and the hierarchial composite outcome of recovery (change in clinical status by day 30). Safety outcomes, in patients who received at least one study medication dose, included serious adverse events, adverse events leading to discontinuation, and adverse events of interest. This study is registered with ClinicalTrials.gov, NCT04350593.\r\n\r\nBetween April 22, 2020 and Jan 1, 2021, 1250 patients were randomly assigned with 625 in each group. The primary composite outcome of prevention showed organ dysfunction or death occurred in 70 patients (11\u00b72%) in the dapagliflozin group, and 86 (13\u00b78%) in the placebo group (hazard ratio [HR] 0\u00b780, 95% CI 0\u00b758-1\u00b710; p=0\u00b717). For the primary outcome of recovery, 547 patients (87\u00b75%) in the dapagliflozin group and 532 (85\u00b71%) in the placebo group showed clinical status improvement, although this was not statistically significant (win ratio 1\u00b709, 95% CI 0\u00b797-1\u00b722; p=0\u00b714). There were 41 deaths (6\u00b76%) in the dapagliflozin group, and 54 (8\u00b76%) in the placebo group (HR 0\u00b777, 95% CI 0\u00b752-1\u00b716). Serious adverse events were reported in 65 (10\u00b76%) of 613 patients treated with dapagliflozin and in 82 (13\u00b73%) of 616 patients given the placebo.\r\n\r\nIn patients with cardiometabolic risk factors who were hospitalised with COVID-19, treatment with dapagliflozin did not result in a statistically significant risk reduction in organ dysfunction or death, or improvement in clinical recovery, but was well tolerated.\r\n\r\nAstraZeneca.", "doi": "10.1016/S2213-8587(21)00180-7", "pmid": "34302745", "labels": {"Category: Biochemistry": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2213-8587(21)00180-7"}, {"db": "pmc", "key": "PMC8294807"}, {"db": "ClinicalTrials.gov", "key": "NCT04350593"}], "notes": [], "created": "2021-08-05T07:04:41.191Z", "modified": "2021-08-05T07:06:23.441Z"}, {"entity": "publication", "iuid": "f679a141107f4d0989dcf6a28593d307", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f679a141107f4d0989dcf6a28593d307.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f679a141107f4d0989dcf6a28593d307"}}, "title": "The role of psychological flexibility, perceived injustice and body image in Vulvodynia: A longitudinal study.", "authors": [{"family": "Chisari", "given": "Claudia", "initials": "C", "orcid": "0000-0002-1118-7443", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7db18ed16a6b4626a61233e39134480f.json"}}, {"family": "Budhraja", "given": "Mahira", "initials": "M", "orcid": "0000-0001-6211-1580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8157535613a1480ea74dba80561d0247.json"}}, {"family": "Monajemi", "given": "Mani B", "initials": "MB", "orcid": "0000-0002-9052-817X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bc7992e02a641258745fd8f24a7d922.json"}}, {"family": "Lewis", "given": "Fiona", "initials": "F", "orcid": "0000-0003-4267-1518", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/229a764990744509b093aafb03e20143.json"}}, {"family": "Moss-Morris", "given": "Rona", "initials": "R", "orcid": "0000-0002-2927-3446", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d47c00d0c4244b2858091fbf7bd0160.json"}}, {"family": "Scott", "given": "Whitney", "initials": "W", "orcid": "0000-0002-2529-9083", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e786db5451e41b99b48253784db8af8.json"}}, {"family": "McCracken", "given": "Lance M", "initials": "LM", "orcid": "0000-0002-9734-0153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e7520672ca04462b00b191b756a1b7a.json"}}], "type": "journal article", "published": "2021-07-20", "journal": {"title": "Eur J Pain", "issn": "1532-2149", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Women with Vulvodynia experience pain, related impacts on sex and daily functioning, and depression. While psychosocial factors are associated with outcomes in Vulvodynia, longitudinal data are limited, especially in mixed/spontaneous Vulvodynia. Broad psychological models such as psychological flexibility (PF) and content-specific factors, such as body-exposure anxiety (BEA) and avoidance during sexual activities and perceived injustice, have not been adequately investigated in Vulvodynia. The aim of this study was to explore whether these factors assessed at baseline predict pain severity, pain interference, sexual functioning and satisfaction and depression 3 months later.\r\n\r\nA longitudinal study of 349 women with Vulvodynia was conducted. Participants completed online self-report measures of pain-related and sexual outcomes, depression, BEA, perceived injustice and facets of PF (present moment awareness, pain acceptance, committed action) at baseline and after 3 months, overlapping with the Coronavirus disease 2019 (COVID-19) pandemic.\r\n\r\nSeventy percent of women responded at both assessments (n = 244). There were significant decreases in pain severity, pain interference, present moment awareness, committed action and a significant increase in depression at 3 months. All the baseline psychosocial factors significantly correlated with at least one outcome at 3 months. When adjusting for baseline outcome and demographics, committed action significantly positively predicted depression at 3 months and pain acceptance significantly positively predicted pain interference at 3 months.\r\n\r\nAmong women with Vulvodynia, pain acceptance and committed action are prospectively associated with pain interference and depression. The reliability and generalizability of these results needs to be established given the overlap with the COVID-19 pandemic. Future studies should investigate whether targeting these factors enhances outcomes in Vulvodynia.\r\n\r\nThis longitudinal study explored the role of PF, perceived injustice and body image during sexual activities in predicting pain severity, pain interference, sexual functioning, sexual satisfaction and depression in women with Vulvodynia. The study findings reveal that two facets of PF (committed action and pain acceptance) predicted pain interference and depression over time. It may be important to incorporate these processes in treatments developed for Vulvodynia.", "doi": "10.1002/ejp.1841", "pmid": "34288269", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-05T11:10:05.526Z", "modified": "2021-11-18T11:42:07.844Z"}, {"entity": "publication", "iuid": "3c1f7865c030414ba948b78279881d3b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3c1f7865c030414ba948b78279881d3b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3c1f7865c030414ba948b78279881d3b"}}, "title": "Self-reported neurocognitive symptoms during COVID-19 lockdown and its associated factors in a sample of psychiatric patients. Results from the BRIS-MHC study.", "authors": [{"family": "Montejo", "given": "Laura", "initials": "L"}, {"family": "Sol\u00e9", "given": "Brisa", "initials": "B"}, {"family": "Verdolini", "given": "Norma", "initials": "N"}, {"family": "Mart\u00ednez-Ar\u00e1n", "given": "Anabel", "initials": "A"}, {"family": "Bonn\u00edn", "given": "Caterina Del Mar", "initials": "CDM"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Mart\u00edn-Villalba", "given": "In\u00e9s", "initials": "I"}, {"family": "Williams", "given": "Evelin", "initials": "E"}, {"family": "Garc\u00eda-Rizo", "given": "Clemente", "initials": "C"}, {"family": "Mezquida", "given": "Gisela", "initials": "G"}, {"family": "Bernardo", "given": "Miguel", "initials": "M"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Torrent", "given": "Carla", "initials": "C"}, {"family": "Amoretti", "given": "Silvia", "initials": "S"}, {"family": "BRIS-MHC research group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-07-20", "journal": {"title": "Eur Neuropsychopharmacol", "issn": "1873-7862", "volume": "53", "pages": "7-18", "issn-l": null}, "abstract": "Lockdown caused by COVID-19 pandemic has a negative impact on mental health. The aim was to assess self-reported neurocognitive symptoms during the lockdown and identify associated vulnerable and protective factors in a sample of psychiatric patients in a Spanish population. These results are part of the Barcelona ResIlience Survey for Mental Health COVID-19 (BRIS-MHC) project. Neurocognitive symptoms were assessed through an online survey considering the five items that represented self-reported neurocognitive complaints. We split the sample into two groups based on the severity of the self-reported neurocognitive complaints: intact cognitive function/mild cognitive impairment (CI-) and moderate/severe cognitive impairment (CI+). Univariate analyses were used to compare both groups in terms of sociodemographic and clinical variables. Multiple logistic regression models were carried out to identify clinical variables and coping strategies associated with neurocognitive symptoms. 198 patients with different psychiatric diagnoses were included in this study. One hundred seventeen patients were classified in the CI- group and 81 in the CI+ group. Depressive symptoms and negative psychotic-like symptoms were vulnerable factors for neurocognitive impairment. Coping strategies of performing physical activity, carrying out relaxing activities and maintaining a routine were protective factors against cognitive impairment. Lockdown situation negatively impact on neurocognitive function. Psychopathological symptoms and coping strategies were associated with neurocognitive symptoms during lockdown in subjects with psychiatric illness. The early treatment of psychopathological symptoms in psychiatric patients and promoting coping strategies during lockdown should be considered an intervention strategy against cognitive impairment.", "doi": "10.1016/j.euroneuro.2021.07.006", "pmid": "34348213", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0924-977X(21)00275-3"}], "notes": [], "created": "2021-08-06T09:43:53.370Z", "modified": "2021-08-06T09:43:53.393Z"}, {"entity": "publication", "iuid": "a7b20101f22d4155888dae5620248fa0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7b20101f22d4155888dae5620248fa0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7b20101f22d4155888dae5620248fa0"}}, "title": "Excess all-cause mortality and COVID-19-related mortality: a temporal analysis in 22 countries, from January until August 2020.", "authors": [{"family": "Achilleos", "given": "Souzana", "initials": "S", "orcid": "0000-0002-1688-9225", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce5b51f054484805abea56ebad2bffc6.json"}}, {"family": "Quattrocchi", "given": "Annalisa", "initials": "A", "orcid": "0000-0002-5764-6721", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9a78ec6310743ec9b60a592a0ac61bd.json"}}, {"family": "Gabel", "given": "John", "initials": "J"}, {"family": "Heraclides", "given": "Alexandros", "initials": "A", "orcid": "0000-0002-1304-3275", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c763a75d0dc4841adfc2f0ea63abb3b.json"}}, {"family": "Kolokotroni", "given": "Ourania", "initials": "O", "orcid": "0000-0002-7653-002X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f695065afcc4c2a9dc89ac04506279b.json"}}, {"family": "Constantinou", "given": "Constantina", "initials": "C"}, {"family": "Pagola Ugarte", "given": "Maider", "initials": "M"}, {"family": "Nicolaou", "given": "Nicoletta", "initials": "N"}, {"family": "Rodriguez-Llanes", "given": "Jose Manuel", "initials": "JM"}, {"family": "Bennett", "given": "Catherine Marie", "initials": "CM"}, {"family": "Bogatyreva", "given": "Ekaterina", "initials": "E"}, {"family": "Schernhammer", "given": "Eva", "initials": "E", "orcid": "0000-0002-4337-9415", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ada7385c4ac4d168d76e00d8383133b.json"}}, {"family": "Zimmermann", "given": "Claudia", "initials": "C"}, {"family": "Costa", "given": "Antonio Jose Leal", "initials": "AJL"}, {"family": "Lobato", "given": "Jackeline Christiane Pinto", "initials": "JCP"}, {"family": "Fernandes", "given": "Ngibo Mubeta", "initials": "NM"}, {"family": "Semedo-Aguiar", "given": "Ana Paula", "initials": "AP"}, {"family": "Jaramillo Ramirez", "given": "Gloria Isabel", "initials": "GI"}, {"family": "Martin Garzon", "given": "Oscar Dario", "initials": "OD"}, {"family": "Mortensen", "given": "Laust Hvas", "initials": "LH"}, {"family": "Critchley", "given": "Julia A", "initials": "JA"}, {"family": "Goldsmith", "given": "Lucy P", "initials": "LP"}, {"family": "Denissov", "given": "Gleb", "initials": "G"}, {"family": "R\u00fc\u00fctel", "given": "Kristi", "initials": "K"}, {"family": "Le Meur", "given": "Nolwenn", "initials": "N", "orcid": "0000-0001-8451-4014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7ccd56127144ac4b7044dfaf98ca8e6.json"}}, {"family": "Kandelaki", "given": "Levan", "initials": "L"}, {"family": "Tsiklauri", "given": "Shorena", "initials": "S"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}, {"family": "Oza", "given": "Ajay", "initials": "A"}, {"family": "Kaufman", "given": "Zalman", "initials": "Z"}, {"family": "Zucker", "given": "Inbar", "initials": "I"}, {"family": "Ambrosio", "given": "Giuseppe", "initials": "G"}, {"family": "Stracci", "given": "Fabrizio", "initials": "F"}, {"family": "Hagen", "given": "Terje P", "initials": "TP"}, {"family": "Erzen", "given": "Ivan", "initials": "I"}, {"family": "Klepac", "given": "Petra", "initials": "P"}, {"family": "Arcos Gonz\u00e1lez", "given": "Pedro", "initials": "P"}, {"family": "Fern\u00e1ndez Camporro", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "Burstr\u00f6m", "given": "Bo", "initials": "B"}, {"family": "Pidmurniak", "given": "Nataliia", "initials": "N"}, {"family": "Verstiuk", "given": "Olesia", "initials": "O"}, {"family": "Huang", "given": "Qian", "initials": "Q"}, {"family": "Mehta", "given": "Neil Kishor", "initials": "NK"}, {"family": "Polemitis", "given": "Antonis", "initials": "A"}, {"family": "Charalambous", "given": "Andreas", "initials": "A"}, {"family": "Demetriou", "given": "Christiana A", "initials": "CA", "orcid": "0000-0003-4002-2880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00673897042047668d72abac855f4cc8.json"}}], "type": "journal article", "published": "2021-07-20", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "issn-l": "0300-5771"}, "abstract": "This study aimed to investigate overall and sex-specific excess all-cause mortality since the inception of the COVID-19 pandemic until August 2020 among 22 countries.\n\nCountries reported weekly or monthly all-cause mortality from January 2015 until the end of June or August 2020. Weekly or monthly COVID-19 deaths were reported for 2020. Excess mortality for 2020 was calculated by comparing weekly or monthly 2020 mortality (observed deaths) against a baseline mortality obtained from 2015-2019 data for the same week or month using two methods: (i) difference in observed mortality rates between 2020 and the 2015-2019 average and (ii) difference between observed and expected 2020 deaths.\n\nBrazil, France, Italy, Spain, Sweden, the UK (England, Wales, Northern Ireland and Scotland) and the USA demonstrated excess all-cause mortality, whereas Australia, Denmark and Georgia experienced a decrease in all-cause mortality. Israel, Ukraine and Ireland demonstrated sex-specific changes in all-cause mortality.\n\nAll-cause mortality up to August 2020 was higher than in previous years in some, but not all, participating countries. Geographical location and seasonality of each country, as well as the prompt application of high-stringency control measures, may explain the observed variability in mortality changes.", "doi": "10.1093/ije/dyab123", "pmid": "34282450", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6324094"}], "notes": [], "created": "2021-08-05T11:10:50.663Z", "modified": "2021-08-05T11:10:50.818Z"}, {"entity": "publication", "iuid": "5180e25d70e04467a74f2ece3c74865d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5180e25d70e04467a74f2ece3c74865d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5180e25d70e04467a74f2ece3c74865d"}}, "title": "Collective insights of public-private partnership impacts and sustainability: A qualitative analysis.", "authors": [{"family": "Strasser", "given": "Sheryl", "initials": "S", "orcid": "0000-0002-6813-7180", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8f19d212059447f80d8a0c0c6c2c341.json"}}, {"family": "Stauber", "given": "Christine", "initials": "C"}, {"family": "Shrivastava", "given": "Ritu", "initials": "R"}, {"family": "Riley", "given": "Patricia", "initials": "P", "orcid": "0000-0002-2901-5834", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5853c1026896400997d09c70f192819b.json"}}, {"family": "O'Quin", "given": "Karen", "initials": "K"}], "type": "journal article", "published": "2021-07-20", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "7", "pages": "e0254495"}, "abstract": "The global Coronavirus or COVID-19 pandemic exposed the weakness of healthcare systems including laboratory systems and is a call to action for unprecedented collaboration and partnerships to deal with the global crisis. The United States (U.S.) President's Emergency Plan for AIDS Relief (PEPFAR) establishes the global HIV/AIDS treatment agenda in alignment with the UNAIDS 90-90-90 treatment targets to achieve epidemic control related to enhanced testing, treatment, and viral suppression. A strategic PEPFAR priority area recognizes that large-scale collective efforts and sharing of resources bear greater potential impact for lasting change than any single organization or entity can achieve alone. An important vehicle utilized within the global public health context is the public-private partnership (PPP) model whereby multiple international organizations forge unified project charters to collectively reach mutually agreed goals. While touted as an ideal mechanism to synthesize resources and maximize gain in numerous applications, little is known from a seasoned stakeholder perspective regarding PPP implementation and sustainability issues. The purpose of this research is to holistically examine perceptions of PPP model sustainability related to inputs and impacts among a collective network of stakeholders experienced with PEPFAR workforce development, laboratory-system strengthening project implementation. Interviews were conducted with frontline stakeholders from public and private sector organizations based in the US and select PEPFAR-supported priority countries. Analysis revealed three dominant themes: PPP impacts, keys of successful collaboration, and logistical challenges and opportunities to enhance sustainability of PPP outcomes in the future.", "doi": "10.1371/journal.pone.0254495", "pmid": "34283847", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-32179"}, {"db": "pmc", "key": "PMC8291689"}], "notes": [], "created": "2021-08-05T11:10:28.875Z", "modified": "2021-11-18T09:37:43.715Z"}, {"entity": "publication", "iuid": "4dbd1bbcf14f4041ade0b1493564840e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4dbd1bbcf14f4041ade0b1493564840e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4dbd1bbcf14f4041ade0b1493564840e"}}, "title": "Assessment of Ventilation and Perfusion in Patients with COVID-19 Discloses Unique Information of Pulmonary Function to a Clinician: Case Reports of V/P SPECT.", "authors": [{"family": "Bajc", "given": "Marika", "initials": "M"}, {"family": "Hedeer", "given": "Fredrik", "initials": "F"}, {"family": "Lindqvist", "given": "Ari", "initials": "A", "orcid": "0000-0002-0062-0117", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1ce81ade04c476facbbdd9ddea80939.json"}}, {"family": "Tr\u00e4g\u00e5rdh", "given": "Elin", "initials": "E"}], "type": "case reports", "published": "2021-07-20", "journal": {"title": "Clin Med Insights Circ Respir Pulm Med", "issn": "1179-5484", "issn-l": null, "volume": "15", "issue": null, "pages": "11795484211030159"}, "abstract": "V/P SPECT from 4 consecutive patients with COVID-19 suggests that ventilation and perfusion images may be applied to diagnose or exclude pulmonary embolism, verify nonsegmental diversion of perfusion from the ventilated areas (dead space ventilation) that may represent inflammation of the pulmonary vasculature, detect the reversed mismatch of poor ventilation and better preserved perfusion (shunt perfusion) in bilateral pulmonary inflammation and indicate redistribution of lung perfusion (antigravitational hyperperfusion) due to cardiac congestion. V/P mismatch and reversed mismatch may be extensive enough to diminish dramatically preserved matching ventilation/perfusion and to induce severe hypoxemia in COVID-19.", "doi": "10.1177/11795484211030159", "pmid": "34349582", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8295940"}, {"db": "pii", "key": "10.1177_11795484211030159"}], "notes": [], "created": "2021-08-06T09:24:03.461Z", "modified": "2023-06-19T15:03:14.197Z"}, {"entity": "publication", "iuid": "648b7d9ffa0c4927b2654baea33b717e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/648b7d9ffa0c4927b2654baea33b717e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/648b7d9ffa0c4927b2654baea33b717e"}}, "title": "Using a household-structured branching process to analyse contact tracing in the SARS-CoV-2 pandemic.", "authors": [{"family": "Fyles", "given": "Martyn", "initials": "M"}, {"family": "Fearon", "given": "Elizabeth", "initials": "E"}, {"family": "Overton", "given": "Christopher", "initials": "C"}, {"family": "University of Manchester COVID-19 Modelling Group", "given": "", "initials": ""}, {"family": "Wingfield", "given": "Tom", "initials": "T"}, {"family": "Medley", "given": "Graham F", "initials": "GF"}, {"family": "Hall", "given": "Ian", "initials": "I"}, {"family": "Pellis", "given": "Lorenzo", "initials": "L"}, {"family": "House", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2021-07-19", "journal": {"title": "Philos Trans R Soc Lond B Biol Sci", "issn": "1471-2970", "issn-l": null, "volume": "376", "issue": "1829", "pages": "20200267"}, "abstract": "We explore strategies of contact tracing, case isolation and quarantine of exposed contacts to control the SARS-CoV-2 epidemic using a branching process model with household structure. This structure reflects higher transmission risks among household members than among non-household members. We explore strategic implementation choices that make use of household structure, and investigate strategies including two-step tracing, backwards tracing, smartphone tracing and tracing upon symptom report rather than test results. The primary model outcome is the effect of contact tracing, in combination with different levels of physical distancing, on the growth rate of the epidemic. Furthermore, we investigate epidemic extinction times to indicate the time period over which interventions must be sustained. We consider effects of non-uptake of isolation/quarantine, non-adherence, and declining recall of contacts over time. Our results find that, compared to self-isolation of cases without contact tracing, a contact tracing strategy designed to take advantage of household structure allows for some relaxation of physical distancing measures but cannot completely control the epidemic absent of other measures. Even assuming no imported cases and sustainment of moderate physical distancing, testing and tracing efforts, the time to bring the epidemic to extinction could be in the order of months to years. This article is part of the theme issue 'Modelling that shaped the early COVID-19 pandemic response in the UK'.", "doi": "10.1098/rstb.2020.0267", "pmid": "34053253", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "URL", "key": "https://github.com/martyn1fyles/HouseholdContactTracing", "description": "Data and code"}], "notes": [], "created": "2021-06-04T11:32:17.300Z", "modified": "2021-11-18T09:36:35.538Z"}, {"entity": "publication", "iuid": "290c919c0c1b4505aaa40d3d71d3c62f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/290c919c0c1b4505aaa40d3d71d3c62f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/290c919c0c1b4505aaa40d3d71d3c62f"}}, "title": "The collaborative outcomes study on health and functioning during infection times in adults (COH-FIT-Adults): Design and methods of an international online survey targeting physical and mental health effects of the COVID-19 pandemic.", "authors": [{"family": "Solmi", "given": "Marco", "initials": "M"}, {"family": "Estrad\u00e9", "given": "Andr\u00e9s", "initials": "A"}, {"family": "Thompson", "given": "Trevor", "initials": "T"}, {"family": "Agorastos", "given": "Agorastos", "initials": "A"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Cortese", "given": "Samuele", "initials": "S"}, {"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Leisch", "given": "Friedrich", "initials": "F"}, {"family": "Vancampfort", "given": "Davy", "initials": "D"}, {"family": "Thygesen", "given": "Lau Caspar", "initials": "LC"}, {"family": "Aschauer", "given": "Harald", "initials": "H"}, {"family": "Schloegelhofer", "given": "Monika", "initials": "M"}, {"family": "Akimova", "given": "Elena", "initials": "E"}, {"family": "Schneeberger", "given": "Andres", "initials": "A"}, {"family": "Huber", "given": "Christian G", "initials": "CG"}, {"family": "Hasler", "given": "Gregor", "initials": "G"}, {"family": "Conus", "given": "Philippe", "initials": "P"}, {"family": "Cu\u00e9nod", "given": "Kim Q Do", "initials": "KQD"}, {"family": "von K\u00e4nel", "given": "Roland", "initials": "R"}, {"family": "Arrondo", "given": "Gonzalo", "initials": "G"}, {"family": "Fusar-Poli", "given": "Paolo", "initials": "P"}, {"family": "Gorwood", "given": "Philip", "initials": "P"}, {"family": "Llorca", "given": "Pierre-Michel", "initials": "PM"}, {"family": "Krebs", "given": "Marie-Odile", "initials": "MO"}, {"family": "Scanferla", "given": "Elisabetta", "initials": "E"}, {"family": "Kishimoto", "given": "Taishiro", "initials": "T"}, {"family": "Rabbani", "given": "Golam", "initials": "G"}, {"family": "Skonieczna-\u017bydecka", "given": "Karolina", "initials": "K"}, {"family": "Brambilla", "given": "Paolo", "initials": "P"}, {"family": "Favaro", "given": "Angela", "initials": "A"}, {"family": "Takamiya", "given": "Akihiro", "initials": "A"}, {"family": "Zoccante", "given": "Leonardo", "initials": "L"}, {"family": "Colizzi", "given": "Marco", "initials": "M"}, {"family": "Bourgin", "given": "Julie", "initials": "J"}, {"family": "Kami\u0144ski", "given": "Karol", "initials": "K"}, {"family": "Moghadasin", "given": "Maryam", "initials": "M"}, {"family": "Seedat", "given": "Soraya", "initials": "S"}, {"family": "Matthews", "given": "Evan", "initials": "E"}, {"family": "Wells", "given": "John", "initials": "J"}, {"family": "Vassilopoulou", "given": "Emilia", "initials": "E"}, {"family": "Gadelha", "given": "Ary", "initials": "A"}, {"family": "Su", "given": "Kuan-Pin", "initials": "KP"}, {"family": "Kwon", "given": "Jun Soo", "initials": "JS"}, {"family": "Kim", "given": "Minah", "initials": "M"}, {"family": "Lee", "given": "Tae Young", "initials": "TY"}, {"family": "Papsuev", "given": "Oleg", "initials": "O"}, {"family": "Mankov\u00e1", "given": "Denisa", "initials": "D"}, {"family": "Boscutti", "given": "Andrea", "initials": "A"}, {"family": "Gerunda", "given": "Cristiano", "initials": "C"}, {"family": "Saccon", "given": "Diego", "initials": "D"}, {"family": "Righi", "given": "Elena", "initials": "E"}, {"family": "Monaco", "given": "Francesco", "initials": "F"}, {"family": "Croatto", "given": "Giovanni", "initials": "G"}, {"family": "Cereda", "given": "Guido", "initials": "G"}, {"family": "Demurtas", "given": "Jacopo", "initials": "J"}, {"family": "Brondino", "given": "Natascia", "initials": "N"}, {"family": "Veronese", "given": "Nicola", "initials": "N"}, {"family": "Enrico", "given": "Paolo", "initials": "P"}, {"family": "Politi", "given": "Pierluigi", "initials": "P"}, {"family": "Ciappolino", "given": "Valentina", "initials": "V"}, {"family": "Pfennig", "given": "Andrea", "initials": "A"}, {"family": "Bechdolf", "given": "Andreas", "initials": "A"}, {"family": "Meyer-Lindenberg", "given": "Andreas", "initials": "A"}, {"family": "Kahl", "given": "Kai G", "initials": "KG"}, {"family": "Domschke", "given": "Katharina", "initials": "K"}, {"family": "Bauer", "given": "Michael", "initials": "M"}, {"family": "Koutsouleris", "given": "Nikolaos", "initials": "N"}, {"family": "Winter", "given": "Sibylle", "initials": "S"}, {"family": "Borgwardt", "given": "Stefan", "initials": "S"}, {"family": "Bitter", "given": "Istvan", "initials": "I"}, {"family": "Balazs", "given": "Judit", "initials": "J"}, {"family": "Czobor", "given": "Pal", "initials": "P"}, {"family": "Unoka", "given": "Zsolt", "initials": "Z"}, {"family": "Mavridis", "given": "Dimitris", "initials": "D"}, {"family": "Tsamakis", "given": "Konstantinos", "initials": "K"}, {"family": "Bozikas", "given": "Vasilios P", "initials": "VP"}, {"family": "Tunvirachaisakul", "given": "Chavit", "initials": "C"}, {"family": "Maes", "given": "Michael", "initials": "M"}, {"family": "Rungnirundorn", "given": "Teerayuth", "initials": "T"}, {"family": "Supasitthumrong", "given": "Thitiporn", "initials": "T"}, {"family": "Haque", "given": "Ariful", "initials": "A"}, {"family": "Brunoni", "given": "Andre R", "initials": "AR"}, {"family": "Costardi", "given": "Carlos Gustavo", "initials": "CG"}, {"family": "Schuch", "given": "Felipe Barreto", "initials": "FB"}, {"family": "Polanczyk", "given": "Guilherme", "initials": "G"}, {"family": "Luiz", "given": "Jhoanne Merlyn", "initials": "JM"}, {"family": "Fonseca", "given": "Lais", "initials": "L"}, {"family": "Aparicio", "given": "Luana V", "initials": "LV"}, {"family": "Valvassori", "given": "Samira S", "initials": "SS"}, {"family": "Nordentoft", "given": "Merete", "initials": "M"}, {"family": "Vendsborg", "given": "Per", "initials": "P"}, {"family": "Hoffmann", "given": "Sofie Have", "initials": "SH"}, {"family": "Sehli", "given": "Jihed", "initials": "J"}, {"family": "Sartorius", "given": "Norman", "initials": "N"}, {"family": "Heuss", "given": "Sabina", "initials": "S"}, {"family": "Guinart", "given": "Daniel", "initials": "D"}, {"family": "Hamilton", "given": "Jane", "initials": "J"}, {"family": "Kane", "given": "John", "initials": "J"}, {"family": "Rubio", "given": "Jose", "initials": "J"}, {"family": "Sand", "given": "Michael", "initials": "M"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Solanes", "given": "Aleix", "initials": "A"}, {"family": "Andreu-Bernabeu", "given": "Alvaro", "initials": "A"}, {"family": "C\u00e1ceres", "given": "Antonia San Jos\u00e9", "initials": "ASJ"}, {"family": "Arango", "given": "Celso", "initials": "C"}, {"family": "D\u00edaz-Caneja", "given": "Covadonga M", "initials": "CM"}, {"family": "Hidalgo-Mazzei", "given": "Diego", "initials": "D"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Gonzalez-Pe\u00f1as", "given": "Javier", "initials": "J"}, {"family": "Fortea", "given": "Lydia", "initials": "L"}, {"family": "Parellada", "given": "Mara", "initials": "M"}, {"family": "Fullana", "given": "Miquel A", "initials": "MA"}, {"family": "Verdolini", "given": "Norma", "initials": "N"}, {"family": "F\u00e1rkov\u00e1", "given": "Eva", "initials": "E"}, {"family": "Jank\u016f", "given": "Karolina", "initials": "K"}, {"family": "Millan", "given": "Mark", "initials": "M"}, {"family": "Honciuc", "given": "Mihaela", "initials": "M"}, {"family": "Moniuszko-Malinowska", "given": "Anna", "initials": "A"}, {"family": "\u0141oniewski", "given": "Igor", "initials": "I"}, {"family": "Samochowiec", "given": "Jerzy", "initials": "J"}, {"family": "Kiszkiel", "given": "\u0141ukasz", "initials": "\u0141"}, {"family": "Marlicz", "given": "Maria", "initials": "M"}, {"family": "Sowa", "given": "Pawe\u0142", "initials": "P"}, {"family": "Marlicz", "given": "Wojciech", "initials": "W"}, {"family": "Spies", "given": "Georgina", "initials": "G"}, {"family": "Stubbs", "given": "Brendon", "initials": "B"}, {"family": "Firth", "given": "Joseph", "initials": "J"}, {"family": "Sullivan", "given": "Sarah", "initials": "S"}, {"family": "Darcin", "given": "Asli Enez", "initials": "AE"}, {"family": "Aksu", "given": "Hatice", "initials": "H"}, {"family": "Dilbaz", "given": "Nesrin", "initials": "N"}, {"family": "Noyan", "given": "Onur", "initials": "O"}, {"family": "Kitazawa", "given": "Momoko", "initials": "M"}, {"family": "Kurokawa", "given": "Shunya", "initials": "S"}, {"family": "Tazawa", "given": "Yuki", "initials": "Y"}, {"family": "Anselmi", "given": "Alejandro", "initials": "A"}, {"family": "Cracco", "given": "Cecilia", "initials": "C"}, {"family": "Machado", "given": "Ana In\u00e9s", "initials": "AI"}, {"family": "Estrade", "given": "Natalia", "initials": "N"}, {"family": "De Leo", "given": "Diego", "initials": "D"}, {"family": "Curtis", "given": "Jackie", "initials": "J"}, {"family": "Berk", "given": "Michael", "initials": "M"}, {"family": "Ward", "given": "Philip", "initials": "P"}, {"family": "Teasdale", "given": "Scott", "initials": "S"}, {"family": "Rosenbaum", "given": "Simon", "initials": "S"}, {"family": "Marx", "given": "Wolfgang", "initials": "W"}, {"family": "Horodnic", "given": "Adrian Vasile", "initials": "AV"}, {"family": "Oprea", "given": "Liviu", "initials": "L"}, {"family": "Alexinschi", "given": "Ovidiu", "initials": "O"}, {"family": "Ifteni", "given": "Petru", "initials": "P"}, {"family": "Turliuc", "given": "Serban", "initials": "S"}, {"family": "Ciuhodaru", "given": "Tudor", "initials": "T"}, {"family": "Bolos", "given": "Alexandra", "initials": "A"}, {"family": "Matei", "given": "Valentin", "initials": "V"}, {"family": "Nieman", "given": "Dorien H", "initials": "DH"}, {"family": "Sommer", "given": "Iris", "initials": "I"}, {"family": "van Os", "given": "Jim", "initials": "J"}, {"family": "van Amelsvoort", "given": "Therese", "initials": "T"}, {"family": "Sun", "given": "Ching-Fang", "initials": "CF"}, {"family": "Guu", "given": "Ta-Wei", "initials": "TW"}, {"family": "Jiao", "given": "Can", "initials": "C"}, {"family": "Zhang", "given": "Jieting", "initials": "J"}, {"family": "Fan", "given": "Jialin", "initials": "J"}, {"family": "Zou", "given": "Liye", "initials": "L"}, {"family": "Yu", "given": "Xin", "initials": "X"}, {"family": "Chi", "given": "Xinli", "initials": "X"}, {"family": "de Timary", "given": "Philippe", "initials": "P"}, {"family": "van Winke", "given": "Ruud", "initials": "R"}, {"family": "Ng", "given": "Bernardo", "initials": "B"}, {"family": "Pena", "given": "Edilberto", "initials": "E"}, {"family": "Arellano", "given": "Ramon", "initials": "R"}, {"family": "Roman", "given": "Raquel", "initials": "R"}, {"family": "Sanchez", "given": "Thelma", "initials": "T"}, {"family": "Movina", "given": "Larisa", "initials": "L"}, {"family": "Morgado", "given": "Pedro", "initials": "P"}, {"family": "Brissos", "given": "Sofia", "initials": "S"}, {"family": "Aizberg", "given": "Oleg", "initials": "O"}, {"family": "Mosina", "given": "Anna", "initials": "A"}, {"family": "Krinitski", "given": "Damir", "initials": "D"}, {"family": "Mugisha", "given": "James", "initials": "J"}, {"family": "Sadeghi-Bahmani", "given": "Dena", "initials": "D"}, {"family": "Sadeghi", "given": "Masoud", "initials": "M"}, {"family": "Hadi", "given": "Samira", "initials": "S"}, {"family": "Brand", "given": "Serge", "initials": "S"}, {"family": "Errazuriz", "given": "Antonia", "initials": "A"}, {"family": "Crossley", "given": "Nicolas", "initials": "N"}, {"family": "Ristic", "given": "Dragana Ignjatovic", "initials": "DI"}, {"family": "L\u00f3pez-Jaramillo", "given": "Carlos", "initials": "C"}, {"family": "Efthymiou", "given": "Dimitris", "initials": "D"}, {"family": "Kuttichira", "given": "Praveenlal", "initials": "P"}, {"family": "Kallivayalil", "given": "Roy Abraham", "initials": "RA"}, {"family": "Javed", "given": "Afzal", "initials": "A"}, {"family": "Afridi", "given": "Muhammad Iqbal", "initials": "MI"}, {"family": "James", "given": "Bawo", "initials": "B"}, {"family": "Seb-Akahomen", "given": "Omonefe Joy", "initials": "OJ"}, {"family": "Fiedorowicz", "given": "Jess", "initials": "J"}, {"family": "Carvalho", "given": "Andre F", "initials": "AF"}, {"family": "Daskalakis", "given": "Jeff", "initials": "J"}, {"family": "Yatham", "given": "Lakshmi N", "initials": "LN"}, {"family": "Yang", "given": "Lin", "initials": "L"}, {"family": "Okasha", "given": "Tarek", "initials": "T"}, {"family": "Dahdouh", "given": "A\u00efcha", "initials": "A"}, {"family": "Gerdle", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Tiihonen", "given": "Jari", "initials": "J"}, {"family": "Shin", "given": "Jae Il", "initials": "JI"}, {"family": "Lee", "given": "Jinhee", "initials": "J"}, {"family": "Mhalla", "given": "Ahmed", "initials": "A"}, {"family": "Gaha", "given": "Lotfi", "initials": "L"}, {"family": "Brahim", "given": "Takoua", "initials": "T"}, {"family": "Altynbekov", "given": "Kuanysh", "initials": "K"}, {"family": "Negay", "given": "Nikolay", "initials": "N"}, {"family": "Nurmagambetova", "given": "Saltanat", "initials": "S"}, {"family": "Jamei", "given": "Yasser Abu", "initials": "YA"}, {"family": "Weiser", "given": "Mark", "initials": "M"}, {"family": "Correll", "given": "Christoph U", "initials": "CU"}], "type": "journal article", "published": "2021-07-19", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "volume": "299", "pages": "393-407", "issn-l": null}, "abstract": ". High-quality comprehensive data on short-/long-term physical/mental health effects of the COVID-19 pandemic are needed.\n\n. The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) is an international, multi-language (n=30) project involving >230 investigators from 49 countries/territories/regions, endorsed by national/international professional associations. COH-FIT is a multi-wave, on-line anonymous, cross-sectional survey [wave 1: 04/2020 until the end of the pandemic, 12 months waves 2/3 starting 6/24 months threreafter] for adults, adolescents (14-17), and children (6-13), utilizing non-probability/snowball and representative sampling. COH-FIT aims to identify non-modifiable/modifiable risk factors/treatment targets to inform prevention/intervention programs to improve social/health outcomes in the general population/vulnerable subgrous during/after COVID-19. In adults, co-primary outcomes are change from pre-COVID-19 to intra-COVID-19 in well-being (WHO-5) and a composite psychopathology P-Score. Key secondary outcomes are a P-extended score, global mental and physical health. Secondary outcomes include health-service utilization/functioning, treatment adherence, functioning, symptoms/behaviors/emotions, substance use, violence, among others.\n\n. Starting 04/26/2020, up to 14/07/2021 >151,000 people from 155 countries/territories/regions and six continents have participated. Representative samples of \u22651,000 adults have been collected in 15 countries. Overall, 43.0% had prior physical disorders, 16.3% had prior mental disorders, 26.5% were health care workers, 8.2% were aged \u226565 years, 19.3% were exposed to someone infected with COVID-19, 76.1% had been in quarantine, and 2.1% had been COVID 19-positive.\n\n. Cross-sectional survey, preponderance of non-representative participants.\n\n. Results from COH-FIT will comprehensively quantify the impact of COVID-19, seeking to identify high-risk groups in need for acute and long-term intervention, and inform evidence-based health policies/strategies during this/future pandemics.", "doi": "10.1016/j.jad.2021.07.048", "pmid": "34949568", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0165-0327(21)00727-8"}, {"db": "pmc", "key": "PMC8288233"}], "notes": [], "created": "2022-01-04T15:28:29.970Z", "modified": "2022-01-04T15:28:38.000Z"}, {"entity": "publication", "iuid": "63c8ec3fd14f4ad59f7b63fdef28e761", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63c8ec3fd14f4ad59f7b63fdef28e761.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63c8ec3fd14f4ad59f7b63fdef28e761"}}, "title": "Systematic evaluation of SARS-CoV-2 antigens enables a highly specific and sensitive multiplex serological COVID-19 assay.", "authors": [{"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc2c612e12284831866002f6759932d5.json"}}, {"family": "Andersson", "given": "Eni", "initials": "E", "orcid": "0000-0002-5115-0637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8200b399e954f3482aec53a62df3b54.json"}}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/282479e5be7c453691d5be4847018b01.json"}}, {"family": "Jernbom Falk", "given": "August", "initials": "A", "orcid": "0000-0002-7773-1851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40d944d7fa964f4292f10012356a2730.json"}}, {"family": "Bayati", "given": "Shaghayegh", "initials": "S"}, {"family": "Mravinacova", "given": "Sara", "initials": "S"}, {"family": "Sj\u00f6berg", "given": "Ronald", "initials": "R", "orcid": "0000-0003-1363-5796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88fa4197c91348bdb1933006a947a9d1.json"}}, {"family": "Yousef", "given": "Jamil", "initials": "J", "orcid": "0000-0001-5915-1258", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/324e111715fc4029badd136232057025.json"}}, {"family": "Skoglund", "given": "Lovisa", "initials": "L"}, {"family": "Kanje", "given": "Sara", "initials": "S"}, {"family": "Berling", "given": "Anna", "initials": "A"}, {"family": "Svensson", "given": "Anne-Sophie", "initials": "AS"}, {"family": "Jensen", "given": "Gabriella", "initials": "G"}, {"family": "Enstedt", "given": "Henric", "initials": "H"}, {"family": "Afshari", "given": "Delaram", "initials": "D"}, {"family": "Xu", "given": "Lan Lan", "initials": "LL"}, {"family": "Zwahlen", "given": "Martin", "initials": "M"}, {"family": "von Feilitzen", "given": "Kalle", "initials": "K"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Lendel", "given": "Christofer", "initials": "C"}, {"family": "Roth", "given": "Robert G", "initials": "RG"}, {"family": "Skoog", "given": "Ingmar", "initials": "I"}, {"family": "Svenungsson", "given": "Elisabet", "initials": "E"}, {"family": "Olsson", "given": "Tomas", "initials": "T"}, {"family": "Fogdell-Hahn", "given": "Anna", "initials": "A"}, {"family": "Lindroth", "given": "Ylva", "initials": "Y"}, {"family": "Lundgren", "given": "Maria", "initials": "M"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Lagerqvist", "given": "Nina", "initials": "N"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Da Silva Rodrigues", "given": "Rui", "initials": "R"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Arroyo M\u00fchr", "given": "Laila Sara", "initials": "LS"}, {"family": "Eklund", "given": "Carina", "initials": "C"}, {"family": "Lagheden", "given": "Camilla", "initials": "C"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Sivertsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f28f2f6ac9648629c2d2de92fe7bb59.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1345-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a53a433db6f04a458e3d420f0c9995c5.json"}}, {"family": "Tegel", "given": "Hanna", "initials": "H", "orcid": "0000-0002-7067-9173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d3fde7ee5de4dab899746becfae364d.json"}}, {"family": "Pin", "given": "Elisa", "initials": "E", "orcid": "0000-0002-2158-2674", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5568b1a9e3c456c8ee4a95eaa55b103.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c735ef404391493980e4e51d70459ce0.json"}}, {"family": "Hedhammar", "given": "My", "initials": "M", "orcid": "0000-0003-0140-419X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/762482db3e014ccc94527d9e71816c80.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}], "type": "journal article", "published": "2021-07-19", "journal": {"title": "Clin Transl Immunol", "issn": "2050-0068", "issn-l": null, "volume": "10", "issue": "7", "pages": "e1312"}, "abstract": "The COVID-19 pandemic poses an immense need for accurate, sensitive and high-throughput clinical tests, and serological assays are needed for both overarching epidemiological studies and evaluating vaccines. Here, we present the development and validation of a high-throughput multiplex bead-based serological assay.\n\nMore than 100 representations of SARS-CoV-2 proteins were included for initial evaluation, including antigens produced in bacterial and mammalian hosts as well as synthetic peptides. The five best-performing antigens, three representing the spike glycoprotein and two representing the nucleocapsid protein, were further evaluated for detection of IgG antibodies in samples from 331 COVID-19 patients and convalescents, and in 2090 negative controls sampled before 2020.\n\nThree antigens were finally selected, represented by a soluble trimeric form and the S1-domain of the spike glycoprotein as well as by the C-terminal domain of the nucleocapsid. The sensitivity for these three antigens individually was found to be 99.7%, 99.1% and 99.7%, and the specificity was found to be 98.1%, 98.7% and 95.7%. The best assay performance was although achieved when utilising two antigens in combination, enabling a sensitivity of up to 99.7% combined with a specificity of 100%. Requiring any two of the three antigens resulted in a sensitivity of 99.7% and a specificity of 99.4%.\n\nThese observations demonstrate that a serological test based on a combination of several SARS-CoV-2 antigens enables a highly specific and sensitive multiplex serological COVID-19 assay.", "doi": "10.1002/cti2.1312", "pmid": "34295471", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Biobanks for COVID-19 research": null, "Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC8288725"}, {"db": "pii", "key": "CTI21312"}], "notes": [], "created": "2021-08-05T07:13:34.602Z", "modified": "2023-06-19T14:23:26.622Z"}, {"entity": "publication", "iuid": "dda9ad76bb694baa8956651c2effe465", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dda9ad76bb694baa8956651c2effe465.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dda9ad76bb694baa8956651c2effe465"}}, "title": "Subjective mental health and need for care among psychiatric outpatients during the COVID-19 pandemic: Results from an outreach initiative in Sweden.", "authors": [{"family": "Flygare", "given": "Oskar", "initials": "O"}, {"family": "Ivanov", "given": "Volen Z", "initials": "VZ"}, {"family": "S\u00e4ll", "given": "Roland", "initials": "R"}, {"family": "Malaise", "given": "Henrik", "initials": "H"}, {"family": "Ivanova", "given": "Ekaterina", "initials": "E"}, {"family": "R\u00fcck", "given": "Christian", "initials": "C"}, {"family": "Jayaram-Lindstr\u00f6m", "given": "Nitya", "initials": "N"}, {"family": "Martinsson", "given": "Lina", "initials": "L"}], "type": "letter", "published": "2021-07-19", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "volume": "304", "pages": "114124", "issn-l": null}, "abstract": null, "doi": "10.1016/j.psychres.2021.114124", "pmid": "34303944", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(21)00420-0"}, {"db": "pmc", "key": "PMC8288212"}], "notes": [], "created": "2021-08-05T07:03:46.909Z", "modified": "2021-08-05T07:03:46.923Z"}, {"entity": "publication", "iuid": "d7e3f2a78e54439bba3157456d2ec4bc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d7e3f2a78e54439bba3157456d2ec4bc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d7e3f2a78e54439bba3157456d2ec4bc"}}, "title": "Real-time monitoring of COVID-19 dynamics using automated trend fitting and anomaly detection.", "authors": [{"family": "Jombart", "given": "Thibaut", "initials": "T"}, {"family": "Ghozzi", "given": "St\u00e9phane", "initials": "S"}, {"family": "Schumacher", "given": "Dirk", "initials": "D"}, {"family": "Taylor", "given": "Timothy J", "initials": "TJ"}, {"family": "Leclerc", "given": "Quentin J", "initials": "QJ"}, {"family": "Jit", "given": "Mark", "initials": "M"}, {"family": "Flasche", "given": "Stefan", "initials": "S"}, {"family": "Greaves", "given": "Felix", "initials": "F"}, {"family": "Ward", "given": "Tom", "initials": "T"}, {"family": "Eggo", "given": "Rosalind M", "initials": "RM"}, {"family": "Nightingale", "given": "Emily", "initials": "E"}, {"family": "Meakin", "given": "Sophie", "initials": "S"}, {"family": "Brady", "given": "Oliver J", "initials": "OJ"}, {"family": "Centre for Mathematical Modelling of Infectious Diseases COVID-19 Working Group", "given": "", "initials": ""}, {"family": "Medley", "given": "Graham F", "initials": "GF"}, {"family": "H\u00f6hle", "given": "Michael", "initials": "M"}, {"family": "Edmunds", "given": "W John", "initials": "WJ"}], "type": "journal article", "published": "2021-07-19", "journal": {"title": "Philos Trans R Soc Lond B Biol Sci", "issn": "1471-2970", "volume": "376", "issue": "1829", "pages": "20200266", "issn-l": null}, "abstract": "As several countries gradually release social distancing measures, rapid detection of new localized COVID-19 hotspots and subsequent intervention will be key to avoiding large-scale resurgence of transmission. We introduce ASMODEE (automatic selection of models and outlier detection for epidemics), a new tool for detecting sudden changes in COVID-19 incidence. Our approach relies on automatically selecting the best (fitting or predicting) model from a range of user-defined time series models, excluding the most recent data points, to characterize the main trend in an incidence. We then derive prediction intervals and classify data points outside this interval as outliers, which provides an objective criterion for identifying departures from previous trends. We also provide a method for selecting the optimal breakpoints, used to define how many recent data points are to be excluded from the trend fitting procedure. The analysis of simulated COVID-19 outbreaks suggests ASMODEE compares favourably with a state-of-art outbreak-detection algorithm while being simpler and more flexible. As such, our method could be of wider use for infectious disease surveillance. We illustrate ASMODEE using publicly available data of National Health Service (NHS) Pathways reporting potential COVID-19 cases in England at a fine spatial scale, showing that the method would have enabled the early detection of the flare-ups in Leicester and Blackburn with Darwen, two to three weeks before their respective lockdown. ASMODEE is implemented in the free R package trendbreaker. This article is part of the theme issue 'Modelling that shaped the early COVID-19 pandemic response in the UK'.", "doi": "10.1098/rstb.2020.0266", "pmid": "34053271", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-06-04T11:31:18.924Z", "modified": "2021-06-04T11:31:18.946Z"}, {"entity": "publication", "iuid": "121c037fbfa3422092e67e3883f756e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/121c037fbfa3422092e67e3883f756e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/121c037fbfa3422092e67e3883f756e2"}}, "title": "COVID-19 in liver transplant candidates: pretransplant and post-transplant outcomes - an ELITA/ELTR multicentre cohort study.", "authors": [{"family": "Belli", "given": "Luca Saverio", "initials": "LS", "orcid": "0000-0001-8714-2439", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1f6c6e519814fc6b8bf380a6589f41e.json"}}, {"family": "Duvoux", "given": "Christophe", "initials": "C"}, {"family": "Cortesi", "given": "Paolo Angelo", "initials": "PA", "orcid": "0000-0001-5241-4473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24fb5550c396431ba1690caeb044c89c.json"}}, {"family": "Facchetti", "given": "Rita", "initials": "R"}, {"family": "Iacob", "given": "Speranta", "initials": "S"}, {"family": "Perricone", "given": "Giovanni", "initials": "G", "orcid": "0000-0003-3890-5393", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a3f2d16c96f4f9bb38a55d4e9e18921.json"}}, {"family": "Radenne", "given": "Sylvie", "initials": "S"}, {"family": "Conti", "given": "Sara", "initials": "S"}, {"family": "Patrono", "given": "Damiano", "initials": "D"}, {"family": "Berlakovich", "given": "Gabriela", "initials": "G"}, {"family": "Hann", "given": "Angus", "initials": "A"}, {"family": "Pasulo", "given": "Luisa", "initials": "L"}, {"family": "Castells", "given": "Lluis", "initials": "L"}, {"family": "Faitot", "given": "Francois", "initials": "F"}, {"family": "Detry", "given": "Olivier", "initials": "O"}, {"family": "Invernizzi", "given": "Federica", "initials": "F"}, {"family": "Magini", "given": "Giulia", "initials": "G"}, {"family": "De Simone", "given": "Paolo", "initials": "P"}, {"family": "Kounis", "given": "Ilias", "initials": "I", "orcid": "0000-0003-3876-2097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00c977ccd8c541e29f5e2466104bda51.json"}}, {"family": "Morelli", "given": "Maria Cristina", "initials": "MC"}, {"family": "D\u00edaz Fontenla", "given": "Fernando", "initials": "F", "orcid": "0000-0002-4700-0281", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9252ae5865e4e6087766dee75e72d43.json"}}, {"family": "Ericzon", "given": "Bo-G\u00f6ran", "initials": "BG"}, {"family": "Loinaz", "given": "Carmelo", "initials": "C"}, {"family": "Johnston", "given": "Chris", "initials": "C"}, {"family": "Gheorghe", "given": "Liliana", "initials": "L"}, {"family": "Lesurtel", "given": "Mickael", "initials": "M"}, {"family": "Romagnoli", "given": "Renato", "initials": "R", "orcid": "0000-0001-8340-8885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd3f53ab108b4c2e93da4a127460010d.json"}}, {"family": "Kollmann", "given": "Dagmar", "initials": "D"}, {"family": "Perera", "given": "M Thamara Pr", "initials": "MTP"}, {"family": "Fagiuoli", "given": "Stefano", "initials": "S"}, {"family": "Mirza", "given": "Darius", "initials": "D"}, {"family": "Coilly", "given": "Audrey", "initials": "A"}, {"family": "Toso", "given": "Christian", "initials": "C"}, {"family": "Zieniewicz", "given": "Krzysztof", "initials": "K"}, {"family": "Elkrief", "given": "Laure", "initials": "L"}, {"family": "Karam", "given": "Vincent", "initials": "V"}, {"family": "Adam", "given": "Rene", "initials": "R"}, {"family": "den Hoed", "given": "Caroline", "initials": "C"}, {"family": "Merli", "given": "Marco", "initials": "M"}, {"family": "Puoti", "given": "Massimo", "initials": "M"}, {"family": "De Carlis", "given": "Luciano", "initials": "L"}, {"family": "Oniscu", "given": "Gabriel C", "initials": "GC"}, {"family": "Piano", "given": "Salvatore", "initials": "S"}, {"family": "Angeli", "given": "Paolo", "initials": "P", "orcid": "0000-0002-1913-0716", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a88accb32a24526a946dcfa6394f23c.json"}}, {"family": "Fondevila", "given": "Constantino", "initials": "C"}, {"family": "Polak", "given": "Wojciech G", "initials": "WG"}, {"family": "for all the centres contributing to the ELITA-ELTR COVID-19 Registry", "given": "", "initials": ""}], "type": "journal article", "published": "2021-07-19", "journal": {"title": "Gut", "issn": "1468-3288", "issn-l": null}, "abstract": "Explore the impact of COVID-19 on patients on the waiting list for liver transplantation (LT) and on their post-LT course.\n\nData from consecutive adult LT candidates with COVID-19 were collected across Europe in a dedicated registry and were analysed.\n\nFrom 21 February to 20 November 2020, 136 adult cases with laboratory-confirmed SARS-CoV-2 infection from 33 centres in 11 European countries were collected, with 113 having COVID-19. Thirty-seven (37/113, 32.7%) patients died after a median of 18 (10-30) days, with respiratory failure being the major cause (33/37, 89.2%). The 60-day mortality risk did not significantly change between first (35.3%, 95% CI 23.9% to 50.0%) and second (26.0%, 95% CI 16.2% to 40.2%) waves. Multivariable Cox regression analysis showed Laboratory Model for End-stage Liver Disease (Lab-MELD) score of \u226515 (Model for End-stage Liver Disease (MELD) score 15-19, HR 5.46, 95% CI 1.81 to 16.50; MELD score\u226520, HR 5.24, 95% CI 1.77 to 15.55) and dyspnoea on presentation (HR 3.89, 95% CI 2.02 to 7.51) being the two negative independent factors for mortality. Twenty-six patients underwent an LT after a median time of 78.5 (IQR 44-102) days, and 25 (96%) were alive after a median follow-up of 118 days (IQR 31-170).\n\nIncreased mortality in LT candidates with COVID-19 (32.7%), reaching 45% in those with decompensated cirrhosis (DC) and Lab-MELD score of \u226515, was observed, with no significant difference between first and second waves of the pandemic. Respiratory failure was the major cause of death. The dismal prognosis of patients with DC supports the adoption of strict preventative measures and the urgent testing of vaccination efficacy in this population. Prior SARS-CoV-2 symptomatic infection did not affect early post-transplant survival (96%).", "doi": "10.1136/gutjnl-2021-324879", "pmid": "34281984", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "gutjnl-2021-324879"}, {"db": "pmc", "key": "PMC8300535"}], "notes": [], "created": "2021-08-05T11:11:29.008Z", "modified": "2021-08-05T11:11:41.499Z"}, {"entity": "publication", "iuid": "d3d37c8fc405417291432990e06c4214", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3d37c8fc405417291432990e06c4214.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3d37c8fc405417291432990e06c4214"}}, "title": "The effectiveness of psychological interventions for loneliness: A systematic review and meta-analysis.", "authors": [{"family": "Hickin", "given": "Nisha", "initials": "N"}, {"family": "K\u00e4ll", "given": "Anton", "initials": "A"}, {"family": "Shafran", "given": "Roz", "initials": "R"}, {"family": "Sutcliffe", "given": "Sebastian", "initials": "S"}, {"family": "Manzotti", "given": "Grazia", "initials": "G"}, {"family": "Langan", "given": "Dean", "initials": "D"}], "type": "journal article", "published": "2021-07-18", "journal": {"title": "Clin Psychol Rev", "issn": "1873-7811", "volume": "88", "pages": "102066", "issn-l": null}, "abstract": "Chronic loneliness is associated with a range of mental health difficulties. Previous theory and research indicate that psychological interventions show promise for reducing loneliness, however, there have been no systematic reviews or meta-analyses to ascertain the efficacy of these interventions across the lifespan. The aim of this study was to synthesise, meta-analyse and explore the heterogeneity in RCTs of psychological interventions for loneliness in order to establish their efficacy. Five databases (Ovid Embase, Ovid Medline, PsycINFO, Web of Science and CINAHL) were systematically searched in order to identify relevant studies. Included studies were required to be peer-reviewed RCTs examining psychological interventions for loneliness. Two independent coders examined the abstracts of the 3973 studies and 103 full texts, finding 31 studies that met inclusion criteria, 28 of which contained sufficient statistical information to be included in the meta-analysis. The quality of included studies was assessed using the Cochrane Risk of Bias Tool. The 31 studies (N = 3959) that were included in the systematic review were conducted with participants from a diverse range of cultures, age groups and populations. The interventions were of mixed quality and were mostly face to face, group-based and delivered weekly. The most common type of intervention was Cognitive Behavioural Therapy (CBT). 28 studies (N = 3039) were included in a meta-analysis which found that psychological interventions significantly reduced loneliness compared to control groups, yielding a small to medium effect size (g = 0.43). Subgroup analysis and meta-regressions were conducted in order to explore heterogeneity and found that type of psychological intervention was approaching significance as a moderator of the effectiveness of psychological interventions for loneliness. In conclusion, psychological interventions for loneliness across the lifespan are effective. This finding should inform policy makers, researchers and clinicians going forward, especially in the context of increased loneliness due to the COVID-19 pandemic. There was considerable heterogeneity in the effectiveness of the interventions, suggesting that future research should also explore what works for whom and consider personalising psychological treatment.", "doi": "10.1016/j.cpr.2021.102066", "pmid": "34339939", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0272-7358(21)00109-4"}], "notes": [], "created": "2021-08-04T10:10:30.940Z", "modified": "2021-08-04T10:10:30.963Z"}, {"entity": "publication", "iuid": "1ddcdc9140bb4536be76b2b64bf7cf2c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ddcdc9140bb4536be76b2b64bf7cf2c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ddcdc9140bb4536be76b2b64bf7cf2c"}}, "title": "Thrombocytopenia with acute ischemic stroke and bleeding in a patient newly vaccinated with an adenoviral vector-based COVID-19 vaccine: COMMENT: COMMENT from Gruel et al.: RESPONSE from Kahn et al.", "authors": [{"family": "Kahn", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-5566-6350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42eda71f3775400599febc10a4e7359c.json"}}, {"family": "Shannon", "given": "Oongh", "initials": "O", "orcid": "0000-0001-8291-8189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7fad6031e2f4a84a8ede77911d3c542.json"}}, {"family": "Bj\u00f6rck", "given": "Lars", "initials": "L"}], "type": "letter", "published": "2021-07-17", "journal": {"title": "J Thromb Haemost", "issn": "1538-7836", "issn-l": null}, "abstract": "We acknowledge the commentary of Gruel et al. on our recent letter [1] and are pleased that the authors agree that IdeS may be a potential treatment option for the rare but potentially severe IgG-mediated platelet activation observed in complications to vaccination with ChAdOx1 nCoV-19. It is apparent that our respective but distinct expertise with regard to IdeS has led us to develop this hypothesis in parallel. As we clearly cited in our original letter these authors have previously contributed important evidence that IdeS may be beneficial in treating IgG-mediated platelet dysfunction in a mouse model of heparin induced thrombocytopenia [2]. The intention with our letter was to provide more background to IdeS and insight into the unique properties of IdeS that make it suitable for treating many manifestations of IgG-mediated human disease.", "doi": "10.1111/jth.15467", "pmid": "34273222", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:14:15.858Z", "modified": "2021-08-06T07:14:15.903Z"}, {"entity": "publication", "iuid": "8f61ddc00ca64be98849030ad2120659", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f61ddc00ca64be98849030ad2120659.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f61ddc00ca64be98849030ad2120659"}}, "title": "Psychosocial experiences of frontline nurses working in hospital-based settings during the COVID-19 pandemic - A qualitative systematic review.", "authors": [{"family": "Xu", "given": "Hongxuan", "initials": "H"}, {"family": "Stjernsw\u00e4rd", "given": "Sigrid", "initials": "S"}, {"family": "Glasdam", "given": "Stinne", "initials": "S"}], "type": "journal article", "published": "2021-07-17", "journal": {"title": "Int J Nurs Stud Adv", "issn": "2666-142X", "pages": "100037", "issn-l": null}, "abstract": "Frontline nurses have been directly exposed to the SARS-CoV-2 virus and come in close contact with patients during the COVID-19 pandemic. Nurses endorse tasks related to disease control and face multiple psychosocial challenges in their frontline work, potentially affecting their mental well-being and ability to satisfyingly perform their tasks.\n\nTo explore the psychosocial experiences of frontline nurses working in hospital-based settings during the COVID-19 pandemic.\n\nThe qualitative systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. Registered in PROSPERO (CRD42021259111).\n\nLiterature searches were performed through PubMed, CINAHL, and the WHO COVID-19 database. Inclusion criteria were: All types of nurses having direct contact with or taking care of patients; Primary, secondary, and tertiary health-care services admitting and treating COVID-19 patients; Experiences, perceptions, feelings, views in psychosocial aspects from the identified population group; Qualitative studies; Mixed methods studies; Language in English; Published date 2019-2021. Exclusion criteria were: Commentaries; Reviews; Discussion papers; Quantitative studies; Language other than English; Published in 2018 or earlier; Studies without an ethical approval and ethical statement.\n\nThe studies were screened and selected based on the inclusion and exclusion criteria. Quality appraisal was conducted according to the Critical Appraisal Skills Program qualitative study checklist. Data was extracted from included studies and a thematic synthesis was made.\n\nA total of 28 studies were included in the review. The experiences of 1141 nurses from 12 countries were synthesised. Four themes were constructed: 'Nurses' emotional, mental and physical reactions to COVID-19', 'A mix of environmental and personal stressors', 'Internally and externally supported coping strategies', and 'A call for future help and support'.\n\nNurses working frontline during the COVID-19 pandemic have experienced psychological, social, and emotional distress in coping with work demands, social relationships, and their personal life. The results pointed to a need for increased psychological and social support for frontline nurses to cope with stress and maintain mental well-being, which may subsequently affect nursing care outcomes.", "doi": "10.1016/j.ijnsa.2021.100037", "pmid": "34308373", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2666-142X(21)00019-9"}, {"db": "pmc", "key": "PMC8285218"}], "notes": [], "created": "2021-08-05T06:53:13.301Z", "modified": "2021-08-05T06:53:13.329Z"}, {"entity": "publication", "iuid": "1c9b866f37de4b0eb739038e2bd2420e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1c9b866f37de4b0eb739038e2bd2420e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1c9b866f37de4b0eb739038e2bd2420e"}}, "title": "COVID-19: counting migrants in.", "authors": [{"family": "Hargreaves", "given": "Sally", "initials": "S"}, {"family": "Hayward", "given": "Sally E", "initials": "SE"}, {"family": "Noori", "given": "Teymur", "initials": "T"}, {"family": "McKee", "given": "Martin", "initials": "M"}, {"family": "Kumar", "given": "Bernadette", "initials": "B"}], "type": "letter", "published": "2021-07-17", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "398", "issue": "10296", "pages": "211-212", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(21)01339-8", "pmid": "34274061", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)01339-8"}, {"db": "pmc", "key": "PMC8285119"}], "notes": [], "created": "2021-08-06T07:13:37.646Z", "modified": "2021-08-06T07:13:37.649Z"}, {"entity": "publication", "iuid": "ff1ecc2c6bd54e4a808421774175fd27", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff1ecc2c6bd54e4a808421774175fd27.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff1ecc2c6bd54e4a808421774175fd27"}}, "title": "The mechanism behind flaring/triggering of autoimmunity disorders associated with COVID-19.", "authors": [{"family": "Redwan", "given": "Elrashdy M", "initials": "EM"}, {"family": "Alghamdi", "given": "Mohammed F", "initials": "MF"}, {"family": "El-Aziz", "given": "Tarek Mohamed Abd", "initials": "TMA"}, {"family": "Adadi", "given": "Parise", "initials": "P"}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA"}, {"family": "Attrish", "given": "Diksha", "initials": "D"}, {"family": "Azad", "given": "Gajendra Kumar", "initials": "GK"}, {"family": "Baetas-da-Cruz", "given": "Wagner", "initials": "W"}, {"family": "Barh", "given": "Debmalya", "initials": "D"}, {"family": "Bazan", "given": "Nicolas G", "initials": "NG"}, {"family": "Brufsky", "given": "Adam M", "initials": "AM"}, {"family": "Chauhan", "given": "Gaurav", "initials": "G"}, {"family": "Hassan", "given": "S K Sarif", "initials": "SKS"}, {"family": "Kandimalla", "given": "Ramesh", "initials": "R"}, {"family": "Lal", "given": "Amos", "initials": "A"}, {"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Mishra", "given": "Yogendra Kumar", "initials": "YK"}, {"family": "Choudhury", "given": "Pabitra Pal", "initials": "PP"}, {"family": "Pal\u00f9", "given": "Giorgio", "initials": "G"}, {"family": "Panda", "given": "Pritam K", "initials": "PK"}, {"family": "Pizzol", "given": "Damiano", "initials": "D"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Serrano-Aroca", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Seyran", "given": "Murat", "initials": "M"}, {"family": "Takayama", "given": "Kazuo", "initials": "K"}, {"family": "Tambuwala", "given": "Murtaza M", "initials": "MM"}, {"family": "Uhal", "given": "Bruce D", "initials": "BD"}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN"}], "type": "letter", "published": "2021-07-16", "journal": {"title": "Autoimmun Rev", "issn": "1873-0183", "volume": "20", "issue": "10", "pages": "102909", "issn-l": null}, "abstract": null, "doi": "10.1016/j.autrev.2021.102909", "pmid": "34274539", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1568-9972(21)00184-1"}, {"db": "pmc", "key": "PMC8282442"}], "notes": [], "created": "2021-08-05T11:15:20.688Z", "modified": "2021-08-05T11:15:33.836Z"}, {"entity": "publication", "iuid": "9628f3c7ffc54d9a9f25a4b79e80675e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9628f3c7ffc54d9a9f25a4b79e80675e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9628f3c7ffc54d9a9f25a4b79e80675e"}}, "title": "Impacts of the COVID-19 epidemic on the department of stomatology in a tertiary hospital: A case study in the General Hospital of the Central Theater Command, Wuhan, China.", "authors": [{"family": "Dong", "given": "Qingshan", "initials": "Q"}, {"family": "Kuria", "given": "Angelica", "initials": "A"}, {"family": "Weng", "given": "Yanming", "initials": "Y"}, {"family": "Liu", "given": "Yu", "initials": "Y"}, {"family": "Cao", "given": "Yang", "initials": "Y", "orcid": "0000-0002-3552-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7594ca0fdf2d4f238ca04a788a405cdb.json"}}], "type": "journal article", "published": "2021-07-16", "journal": {"title": "Community Dent Oral Epidemiol", "issn": "1600-0528", "issn-l": null}, "abstract": "The impact of the worldwide COVID-19 pandemic on the dental community is evident. Dental education programmes and academic activities have suffered from the ramifications of the pandemic. This study aimed to depict the impacts of the COVID-19 epidemic on the clinical services and academic activities in the department of stomatology of a tertiary hospital in Wuhan, China.\n\nWe obtained historical data of the Department of Stomatology from the Health Information System of the General Hospital of Central Theater Command, Wuhan, China between January 2018 and June 2020. Mean, standard deviation and median with interquartile range were used to summarize the variables. Line plots were used to illustrate the temporal trend. The Kruskal-Wallis equality-of-populations rank test was used to compare the difference between groups.\n\nA significant decrease was noted in the monthly average number of patients seeking outpatient services for the year 2020, which were decreased by two-thirds from 2018 to 2020. The number of emergency cases also decreased significantly by 57.6% in 2020. The monthly number of teaching hours decreased from 3.8 \u00b1 1.5 in 2018 and 4.7 \u00b1 1.4 in 2019 to 1.7 \u00b1 1.9 in 2020. The number of interns also decreased by more than 77.0% in 2020.\n\nThe impacts of COVID-19 in the stomatology clinic were significant with notable decreases in clinical services and education offered to the stomatology students. There is a need to find solutions to keep as many dental professionals as needed remaining on the frontline of oral health care.", "doi": "10.1111/cdoe.12680", "pmid": "34270106", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:15:46.033Z", "modified": "2021-08-06T07:15:46.092Z"}, {"entity": "publication", "iuid": "7a85e9c9d7584294bc016757ec2c0457", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a85e9c9d7584294bc016757ec2c0457.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a85e9c9d7584294bc016757ec2c0457"}}, "title": "COVID-19: the turning point for gender equality.", "authors": [{"family": "Fisseha", "given": "Senait", "initials": "S"}, {"family": "Sen", "given": "Gita", "initials": "G"}, {"family": "Ghebreyesus", "given": "Tedros Adhanom", "initials": "TA"}, {"family": "Byanyima", "given": "Winnie", "initials": "W"}, {"family": "Diniz", "given": "Debora", "initials": "D"}, {"family": "Fore", "given": "Henrietta H", "initials": "HH"}, {"family": "Kanem", "given": "Natalia", "initials": "N"}, {"family": "Karlsson", "given": "Ulrika", "initials": "U"}, {"family": "Khosla", "given": "Rajat", "initials": "R"}, {"family": "Laski", "given": "Laura", "initials": "L"}, {"family": "Mired", "given": "Dina", "initials": "D"}, {"family": "Mlambo-Ngcuka", "given": "Phumzile", "initials": "P"}, {"family": "Mofokeng", "given": "Tlaleng", "initials": "T"}, {"family": "Gupta", "given": "Geeta Rao", "initials": "GR"}, {"family": "Steiner", "given": "Achim", "initials": "A"}, {"family": "Remme", "given": "Michelle", "initials": "M"}, {"family": "Allotey", "given": "Pascale", "initials": "P"}], "type": "journal article", "published": "2021-07-16", "journal": {"title": "Lancet", "issn": "1474-547X", "issn-l": "0140-6736", "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/S0140-6736(21)01651-2", "pmid": "34280381", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)01651-2"}], "notes": [], "created": "2021-08-05T11:12:05.803Z", "modified": "2022-11-23T08:55:18.950Z"}, {"entity": "publication", "iuid": "4cd20fd2bdb64f5e87475df7bb09b952", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4cd20fd2bdb64f5e87475df7bb09b952.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4cd20fd2bdb64f5e87475df7bb09b952"}}, "title": "COVID-19 vaccine acceptance and hesitancy in low- and middle-income countries.", "authors": [{"family": "Sol\u00eds Arce", "given": "Julio S", "initials": "JS", "orcid": "0000-0002-0759-4142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a550afd02b5045898e009f00555d5de1.json"}}, {"family": "Warren", "given": "Shana S", "initials": "SS", "orcid": "0000-0002-2096-1402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9fc163cf8da54bbc85ee05b5fdc233f5.json"}}, {"family": "Meriggi", "given": "Niccol\u00f2 F", "initials": "NF", "orcid": "0000-0002-6757-1284", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04af70c72e0142439785ce0468521588.json"}}, {"family": "Scacco", "given": "Alexandra", "initials": "A", "orcid": "0000-0002-7282-2762", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74d1a467dea7477dabe24a2e178e0efb.json"}}, {"family": "McMurry", "given": "Nina", "initials": "N", "orcid": "0000-0003-3974-3170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2165ef7ad1d476faf3c6ef8b99019c3.json"}}, {"family": "Voors", "given": "Maarten", "initials": "M"}, {"family": "Syunyaev", "given": "Georgiy", "initials": "G"}, {"family": "Malik", "given": "Amyn Abdul", "initials": "AA", "orcid": "0000-0003-4875-9916", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be5d083c5e424b3cb0a828fc7f0e7e9a.json"}}, {"family": "Aboutajdine", "given": "Samya", "initials": "S"}, {"family": "Adeojo", "given": "Opeyemi", "initials": "O"}, {"family": "Anigo", "given": "Deborah", "initials": "D"}, {"family": "Armand", "given": "Alex", "initials": "A", "orcid": "0000-0003-1326-7348", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4e3e32500464ea2b4579d9755efb01d.json"}}, {"family": "Asad", "given": "Saher", "initials": "S"}, {"family": "Atyera", "given": "Martin", "initials": "M"}, {"family": "Augsburg", "given": "Britta", "initials": "B"}, {"family": "Awasthi", "given": "Manisha", "initials": "M"}, {"family": "Ayesiga", "given": "Gloria Eden", "initials": "GE"}, {"family": "Bancalari", "given": "Antonella", "initials": "A"}, {"family": "Bj\u00f6rkman Nyqvist", "given": "Martina", "initials": "M"}, {"family": "Borisova", "given": "Ekaterina", "initials": "E"}, {"family": "Bosancianu", "given": "Constantin Manuel", "initials": "CM", "orcid": "0000-0001-7950-9798", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/97f42ea2eb8a4b019c851b2a3928b10e.json"}}, {"family": "Cabra Garc\u00eda", "given": "Magarita Rosa", "initials": "MR"}, {"family": "Cheema", "given": "Ali", "initials": "A"}, {"family": "Collins", "given": "Elliott", "initials": "E"}, {"family": "Cuccaro", "given": "Filippo", "initials": "F"}, {"family": "Farooqi", "given": "Ahsan Zia", "initials": "AZ"}, {"family": "Fatima", "given": "Tatheer", "initials": "T"}, {"family": "Fracchia", "given": "Mattia", "initials": "M"}, {"family": "Galindo Soria", "given": "Mery Len", "initials": "ML"}, {"family": "Guariso", "given": "Andrea", "initials": "A", "orcid": "0000-0003-2128-7322", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0d94919ffa548bc8b77f2b454af38b9.json"}}, {"family": "Hasanain", "given": "Ali", "initials": "A"}, {"family": "Jaramillo", "given": "Sof\u00eda", "initials": "S"}, {"family": "Kallon", "given": "Sellu", "initials": "S"}, {"family": "Kamwesigye", "given": "Anthony", "initials": "A"}, {"family": "Kharel", "given": "Arjun", "initials": "A"}, {"family": "Kreps", "given": "Sarah", "initials": "S"}, {"family": "Levine", "given": "Madison", "initials": "M"}, {"family": "Littman", "given": "Rebecca", "initials": "R"}, {"family": "Malik", "given": "Mohammad", "initials": "M"}, {"family": "Manirabaruta", "given": "Gisele", "initials": "G"}, {"family": "Mfura", "given": "Jean L\u00e9odomir Habarimana", "initials": "JLH"}, {"family": "Momoh", "given": "Fatoma", "initials": "F"}, {"family": "Mucauque", "given": "Alberto", "initials": "A"}, {"family": "Mussa", "given": "Imamo", "initials": "I"}, {"family": "Nsabimana", "given": "Jean Aime", "initials": "JA"}, {"family": "Obara", "given": "Isaac", "initials": "I"}, {"family": "Ot\u00e1lora", "given": "Mar\u00eda Juliana", "initials": "MJ"}, {"family": "Ou\u00e9draogo", "given": "B\u00e9chir Wendemi", "initials": "BW"}, {"family": "Pare", "given": "Touba Bakary", "initials": "TB"}, {"family": "Platas", "given": "Melina R", "initials": "MR"}, {"family": "Polanco", "given": "Laura", "initials": "L"}, {"family": "Qureshi", "given": "Javaeria Ashraf", "initials": "JA"}, {"family": "Raheem", "given": "Mariam", "initials": "M"}, {"family": "Ramakrishna", "given": "Vasudha", "initials": "V"}, {"family": "Rendr\u00e1", "given": "Ismail", "initials": "I"}, {"family": "Shah", "given": "Taimur", "initials": "T"}, {"family": "Shaked", "given": "Sarene Eyla", "initials": "SE"}, {"family": "Shapiro", "given": "Jacob N", "initials": "JN", "orcid": "0000-0002-7484-229X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac5199c2900d43528cd55e05477568f7.json"}}, {"family": "Svensson", "given": "Jakob", "initials": "J"}, {"family": "Tariq", "given": "Ahsan", "initials": "A"}, {"family": "Tchibozo", "given": "Achille Mignondo", "initials": "AM"}, {"family": "Tiwana", "given": "Hamid Ali", "initials": "HA"}, {"family": "Trivedi", "given": "Bhartendu", "initials": "B"}, {"family": "Vernot", "given": "Corey", "initials": "C"}, {"family": "Vicente", "given": "Pedro C", "initials": "PC"}, {"family": "Weissinger", "given": "Laurin B", "initials": "LB"}, {"family": "Zafar", "given": "Basit", "initials": "B"}, {"family": "Zhang", "given": "Baobao", "initials": "B", "orcid": "0000-0001-7217-5035", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/929146a8be5e42f3bfffcfafc832897f.json"}}, {"family": "Karlan", "given": "Dean", "initials": "D"}, {"family": "Callen", "given": "Michael", "initials": "M"}, {"family": "Teachout", "given": "Matthieu", "initials": "M"}, {"family": "Humphreys", "given": "Macartan", "initials": "M", "orcid": "0000-0001-7029-2326", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb6b3ca6ea5c4a1cbfdf7d267a54681f.json"}}, {"family": "Mobarak", "given": "Ahmed Mushfiq", "initials": "AM", "orcid": "0000-0002-1916-3438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e85f61d8aa4409b9ffda626a51992c3.json"}}, {"family": "Omer", "given": "Saad B", "initials": "SB", "orcid": "0000-0002-5383-3474", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e884245e39b4a56945252223e3ca7d1.json"}}], "type": "journal article", "published": "2021-07-16", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956", "volume": null, "issue": null, "pages": null}, "abstract": "Widespread acceptance of COVID-19 vaccines is crucial for achieving sufficient immunization coverage to end the global pandemic, yet few studies have investigated COVID-19 vaccination attitudes in lower-income countries, where large-scale vaccination is just beginning. We analyze COVID-19 vaccine acceptance across 15 survey samples covering 10 low- and middle-income countries (LMICs) in Asia, Africa and South America, Russia (an upper-middle-income country) and the United States, including a total of 44,260 individuals. We find considerably higher willingness to take a COVID-19 vaccine in our LMIC samples (mean 80.3%; median 78%; range 30.1 percentage points) compared with the United States (mean 64.6%) and Russia (mean 30.4%). Vaccine acceptance in LMICs is primarily explained by an interest in personal protection against COVID-19, while concern about side effects is the most common reason for hesitancy. Health workers are the most trusted sources of guidance about COVID-19 vaccines. Evidence from this sample of LMICs suggests that prioritizing vaccine distribution to the Global South should yield high returns in advancing global immunization coverage. Vaccination campaigns should focus on translating the high levels of stated acceptance into actual uptake. Messages highlighting vaccine efficacy and safety, delivered by healthcare workers, could be effective for addressing any remaining hesitancy in the analyzed LMICs.", "doi": "10.1038/s41591-021-01454-y", "pmid": "34272499", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-021-01454-y"}, {"db": "URL", "key": "https://github.com/wzb-ipi/covid_vaccines_nmed", "description": "Individual participant data (de-identified), analytic code and replication file"}], "notes": [], "created": "2021-08-06T07:15:21.576Z", "modified": "2021-11-18T09:32:07.573Z"}, {"entity": "publication", "iuid": "6a7b600ff4f5428ab46a9fbca3f25d5f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a7b600ff4f5428ab46a9fbca3f25d5f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a7b600ff4f5428ab46a9fbca3f25d5f"}}, "title": "Swedish Primary Care Physicians' Intentions to Use Telemedicine: A Survey Using a New Questionnaire - Physician Attitudes and Intentions to Use Telemedicine (PAIT).", "authors": [{"family": "Pikkemaat", "given": "Miriam", "initials": "M", "orcid": "0000-0002-9808-207X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb63140be25f4d13a430425313f1b209.json"}}, {"family": "Thulesius", "given": "Hans", "initials": "H", "orcid": "0000-0002-3785-5630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f7d45ab8dd94b89873fb2e44a0a8770.json"}}, {"family": "Milos Nymberg", "given": "Veronica", "initials": "V", "orcid": "0000-0002-3836-3048", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b591c9689b44c7c884187d0827e84a4.json"}}], "type": "journal article", "published": "2021-07-15", "journal": {"title": "Int J Gen Med", "issn": "1178-7074", "volume": "14", "pages": "3445-3455", "issn-l": null}, "abstract": "Research on intentions to use telemedicine in primary care is sparse. This survey study explored primary care physicians' intentions to use telemedicine by using a newly developed questionnaire: Physician Attitudes and Intentions to use Telemedicine.\n\nAn anonymous web-survey with questions focusing on theory-based predictors of behavioral intentions such as Attitudes, Subjective norms and Perceived behavioral control was designed, validated, and sent to all primary care physicians at 160 primary health care centers in southern Sweden from May to August 2019. The questionnaire had 29 subject items (including 49 multiple-choice sub-items). Main outcome measures were intentions to use three domains of telemedicine and correlation between theory-based predictors and behavioral intentions for using telemedicine.\n\nThe survey was validated by an expert group, amended, and then tested and retested. A majority of the 198 physicians who returned the web-surveys reported that they did not use e-mails (68%), nor video consultations (78%), chat (81%), or text messages (86%) in their everyday patient work. Yet, most physicians described a positive intention to use telemedicine in patient care for all three studied domains with Attitudes and Perceived behavioral control being significant predictors (p<0.01) for Intentions to use digital contacts (R2 = 0.54), chronic disease monitoring with digital tools (R2 = 0.47) and artificial intelligence (R2 = 0.54). A structural validation of a preliminary instrument - Physician Attitudes and Intention to use Telemedicine (PAIT) - containing 28 sub-items was done by exploratory factor analysis with acceptable explanatory, reliability and sampling adequacy measures. Five factors emerged with Eigenvalues between 1.6 and 11.1 explaining 72% of the variance. Total Cronbach's alpha was 0.91 and Kaiser-Meyer-Olkirk 0.79.\n\nBefore the covid-19 pandemic, Swedish primary care physicians reported a low use yet high behavioral intention to use telemedicine in a study where we developed the preliminary instrument Physician Attitudes and Intention to use Telemedicine. Perceived behavioral control had the largest predictive value of behavioral intention to use telemedicine. Thus, interventions aiming to increase the use of digital tools in primary care should possibly focus on empowering physicians' self-efficacy towards using them.", "doi": "10.2147/IJGM.S319497", "pmid": "34295177", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "319497"}, {"db": "pmc", "key": "PMC8290350"}], "notes": [], "created": "2021-08-05T11:07:17.298Z", "modified": "2021-08-05T11:07:17.397Z"}, {"entity": "publication", "iuid": "699431106f864e8b87a9e02f13caa5dc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/699431106f864e8b87a9e02f13caa5dc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/699431106f864e8b87a9e02f13caa5dc"}}, "title": "Potential natural polymer-based nanofibres for the development of facemasks in countering viral outbreaks.", "authors": [{"family": "Shanmugam", "given": "Vigneshwaran", "initials": "V"}, {"family": "Babu", "given": "Karthik", "initials": "K"}, {"family": "Garrison", "given": "Thomas F", "initials": "TF"}, {"family": "Capezza", "given": "Antonio J", "initials": "AJ"}, {"family": "Olsson", "given": "Richard T", "initials": "RT"}, {"family": "Ramakrishna", "given": "Seeram", "initials": "S"}, {"family": "Hedenqvist", "given": "Mikael S", "initials": "MS"}, {"family": "Singha", "given": "Shuvra", "initials": "S"}, {"family": "Bartoli", "given": "Mattia", "initials": "M"}, {"family": "Giorcelli", "given": "Mauro", "initials": "M"}, {"family": "Sas", "given": "Gabriel", "initials": "G"}, {"family": "F\u00f6rsth", "given": "Michael", "initials": "M"}, {"family": "Das", "given": "Oisik", "initials": "O", "orcid": "0000-0002-5474-1512", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8b8e5009c55423ba971d148bbe6e7f3.json"}}, {"family": "Rest\u00e1s", "given": "\u00c1goston", "initials": "\u00c1"}, {"family": "Berto", "given": "Filippo", "initials": "F"}], "type": "journal article", "published": "2021-07-15", "journal": {"title": "J Appl Polym Sci", "issn": "0021-8995", "volume": "138", "issue": "27", "pages": "50658", "issn-l": null}, "abstract": "The global coronavirus disease 2019 (COVID-19) pandemic has rapidly increased the demand for facemasks as a measure to reduce the rapid spread of the pathogen. Throughout the pandemic, some countries such as Italy had a monthly demand of ca. 90 million facemasks. Domestic mask manufacturers are capable of manufacturing 8 million masks each week, although the demand was 40 million per week during March 2020. This dramatic increase has contributed to a spike in the generation of facemask waste. Facemasks are often manufactured with synthetic materials that are non-biodegradable, and their increased usage and improper disposal are raising environmental concerns. Consequently, there is a strong interest for developing biodegradable facemasks made with for example, renewable nanofibres. A range of natural polymer-based nanofibres has been studied for their potential to be used in air filter applications. This review article examines potential natural polymer-based nanofibres along with their filtration and antimicrobial capabilities for developing biodegradable facemask that will promote a cleaner production.", "doi": "10.1002/app.50658", "pmid": "34149062", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "APP50658"}, {"db": "pmc", "key": "PMC8206777"}], "notes": [], "created": "2021-06-28T18:25:24.367Z", "modified": "2021-06-28T18:25:41.850Z"}, {"entity": "publication", "iuid": "0b057b65dd734658b81f1de2a041377d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b057b65dd734658b81f1de2a041377d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b057b65dd734658b81f1de2a041377d"}}, "title": "Characteristics and outcomes of 627 044 COVID-19 patients living with and without obesity in the United States, Spain, and the United Kingdom.", "authors": [{"family": "Recalde", "given": "Martina", "initials": "M"}, {"family": "Roel", "given": "Elena", "initials": "E", "orcid": "0000-0002-1964-3546", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad1d9cc65d3242339540f938eeceafe1.json"}}, {"family": "Pistillo", "given": "Andrea", "initials": "A", "orcid": "0000-0002-4467-0220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/055156368b8845a0bfdc522a53cc1b0d.json"}}, {"family": "Sena", "given": "Anthony G", "initials": "AG", "orcid": "0000-0001-8630-5347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9202e069d9c24646b006b6abb640b541.json"}}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A", "orcid": "0000-0003-1202-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47f086bb6ccd49a2a5f11a32c06277c8.json"}}, {"family": "Ahmed", "given": "Waheed-Ul-Rahman", "initials": "W"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM", "orcid": "0000-0002-5630-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5162aab03bc04dafa809108461f18667.json"}}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Areia", "given": "Carlos", "initials": "C", "orcid": "0000-0002-4668-7069", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7232f54be5df43f0b984d0117d88a054.json"}}, {"family": "Burn", "given": "Edward", "initials": "E"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "Dawoud", "given": "Dalia", "initials": "D"}, {"family": "DuVall", "given": "Scott L", "initials": "SL"}, {"family": "Falconer", "given": "Thomas", "initials": "T"}, {"family": "Fern\u00e1ndez-Bertol\u00edn", "given": "Sergio", "initials": "S"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Gong", "given": "Mengchun", "initials": "M"}, {"family": "Lai", "given": "Lana Yin Hui", "initials": "LYH"}, {"family": "Lane", "given": "Jennifer C E", "initials": "JCE"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Mehta", "given": "Paras P", "initials": "PP"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Natarjan", "given": "Karthik", "initials": "K"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Reich", "given": "Christian G", "initials": "CG"}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR"}, {"family": "Schilling", "given": "Lisa M", "initials": "LM"}, {"family": "Shah", "given": "Karishma", "initials": "K"}, {"family": "Shah", "given": "Nigam H", "initials": "NH"}, {"family": "Subbian", "given": "Vignesh", "initials": "V"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhu", "given": "Hong", "initials": "H"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}], "type": "journal article", "published": "2021-07-15", "journal": {"title": "Int J Obes (Lond)", "issn": "1476-5497", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "A detailed characterization of patients with COVID-19 living with obesity has not yet been undertaken. We aimed to describe and compare the demographics, medical conditions, and outcomes of COVID-19 patients living with obesity (PLWO) to those of patients living without obesity.\r\n\r\nWe conducted a cohort study based on outpatient/inpatient care and claims data from January to June 2020 from Spain, the UK, and the US. We used six databases standardized to the OMOP common data model. We defined two non-mutually exclusive cohorts of patients diagnosed and/or hospitalized with COVID-19; patients were followed from index date to 30 days or death. We report the frequency of demographics, prior medical conditions, and 30-days outcomes (hospitalization, events, and death) by obesity status.\r\n\r\nWe included 627 044 (Spain: 122 058, UK: 2336, and US: 502 650) diagnosed and 160 013 (Spain: 18 197, US: 141 816) hospitalized patients with COVID-19. The prevalence of obesity was higher among patients hospitalized (39.9%, 95%CI: 39.8-40.0) than among those diagnosed with COVID-19 (33.1%; 95%CI: 33.0-33.2). In both cohorts, PLWO were more often female. Hospitalized PLWO were younger than patients without obesity. Overall, COVID-19 PLWO were more likely to have prior medical conditions, present with cardiovascular and respiratory events during hospitalization, or require intensive services compared to COVID-19 patients without obesity.\r\n\r\nWe show that PLWO differ from patients without obesity in a wide range of medical conditions and present with more severe forms of COVID-19, with higher hospitalization rates and intensive services requirements. These findings can help guiding preventive strategies of COVID-19 infection and complications and generating hypotheses for causal inference studies.", "doi": "10.1038/s41366-021-00893-4", "pmid": "34267326", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41366-021-00893-4"}, {"db": "pmc", "key": "PMC8281807"}, {"db": "URL", "key": "https://github.com/ohdsi-studies/Covid19CharacterizationCharybdis", "description": "Analytic code"}], "notes": [], "created": "2021-08-06T07:17:27.168Z", "modified": "2021-11-18T09:18:58.826Z"}, {"entity": "publication", "iuid": "4ddc361323c5468eab930e96219f795c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ddc361323c5468eab930e96219f795c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ddc361323c5468eab930e96219f795c"}}, "title": "The Impact of Stress on Health in Childhood and Adolescence in the Era of the COVID-19 Pandemic.", "authors": [{"family": "Cianfarani", "given": "Stefano", "initials": "S"}, {"family": "Pampanini", "given": "Valentina", "initials": "V"}], "type": "journal article", "published": "2021-07-14", "journal": {"title": "Horm Res Paediatr", "issn": "1663-2826", "pages": "1-5", "issn-l": "1663-2818"}, "abstract": "The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is posing many challenges to global health. Efforts from the whole scientific community have shed light on the pathogenetic mechanisms and the clinical features of SARS-CoV-2 infection as well as on potential therapeutic strategies.\n\nThe consequences of stress related to social isolation and anxiety generated by the pandemic on mental and physical health are collateral effects that are yet poorly investigated.", "doi": "10.1159/000517460", "pmid": "34261075", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "000517460"}], "notes": [], "created": "2021-08-06T07:19:08.206Z", "modified": "2021-08-06T07:19:45.627Z"}, {"entity": "publication", "iuid": "e94c3a552cb04f328a59e337030ffa31", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e94c3a552cb04f328a59e337030ffa31.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e94c3a552cb04f328a59e337030ffa31"}}, "title": "Host-Pathogen Adhesion as the Basis of Innovative Diagnostics for Emerging Pathogens.", "authors": [{"family": "van Belkum", "given": "Alex", "initials": "A", "orcid": "0000-0001-8545-5108", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d38c5ad8612e40d89df78b7e4fbd1ce3.json"}}, {"family": "Almeida", "given": "Carina", "initials": "C"}, {"family": "Bardiaux", "given": "Benjamin", "initials": "B", "orcid": "0000-0003-4014-9195", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef17bbca06e94bb4afdda56f85ac801c.json"}}, {"family": "Barrass", "given": "Sarah V", "initials": "SV"}, {"family": "Butcher", "given": "Sarah J", "initials": "SJ"}, {"family": "\u00c7aykara", "given": "Tu\u011f\u00e7e", "initials": "T"}, {"family": "Chowdhury", "given": "Sounak", "initials": "S"}, {"family": "Datar", "given": "Rucha", "initials": "R"}, {"family": "Eastwood", "given": "Ian", "initials": "I"}, {"family": "Goldman", "given": "Adrian", "initials": "A"}, {"family": "Goyal", "given": "Manisha", "initials": "M"}, {"family": "Happonen", "given": "Lotta", "initials": "L"}, {"family": "Izadi-Pruneyre", "given": "Nadia", "initials": "N"}, {"family": "Jacobsen", "given": "Theis", "initials": "T"}, {"family": "Johnson", "given": "Pirjo H", "initials": "PH"}, {"family": "Kempf", "given": "Volkhard A J", "initials": "VAJ"}, {"family": "Kiessling", "given": "Andreas", "initials": "A"}, {"family": "Bueno", "given": "Juan Leva", "initials": "JL"}, {"family": "Malik", "given": "Anchal", "initials": "A"}, {"family": "Malmstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0002-2889-7169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e42dacb3a60b456dbbfb3e0a0c51a606.json"}}, {"family": "Meuskens", "given": "Ina", "initials": "I"}, {"family": "Milner", "given": "Paul A", "initials": "PA"}, {"family": "Nilges", "given": "Michael", "initials": "M"}, {"family": "Pamme", "given": "Nicole", "initials": "N", "orcid": "0000-0002-9391-9387", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1000b4c42944339b4f3eedf7a7deb8b.json"}}, {"family": "Peyman", "given": "Sally A", "initials": "SA", "orcid": "0000-0002-1600-5100", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f53dab03308c44ca98d7af152064b37e.json"}}, {"family": "Rodrigues", "given": "Ligia R", "initials": "LR", "orcid": "0000-0001-9265-0630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dcb8d38170cd4c3a80047faf3771246c.json"}}, {"family": "Rodriguez-Mateos", "given": "Pablo", "initials": "P"}, {"family": "Sande", "given": "Maria G", "initials": "MG"}, {"family": "Silva", "given": "Carla Joana", "initials": "CJ"}, {"family": "Stasiak", "given": "Aleksandra Cecylia", "initials": "AC", "orcid": "0000-0001-6914-5740", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d91d81aaa6b4328b45f43a294276ae0.json"}}, {"family": "Stehle", "given": "Thilo", "initials": "T"}, {"family": "Thibau", "given": "Arno", "initials": "A"}, {"family": "Vaca", "given": "Diana J", "initials": "DJ"}, {"family": "Linke", "given": "Dirk", "initials": "D"}], "type": "journal article", "published": "2021-07-14", "journal": {"title": "Diagnostics (Basel)", "issn": "2075-4418", "volume": "11", "issue": "7", "issn-l": null}, "abstract": "Infectious diseases are an existential health threat, potentiated by emerging and re-emerging viruses and increasing bacterial antibiotic resistance. Targeted treatment of infectious diseases requires precision diagnostics, especially in cases where broad-range therapeutics such as antibiotics fail. There is thus an increasing need for new approaches to develop sensitive and specific in vitro diagnostic (IVD) tests. Basic science and translational research are needed to identify key microbial molecules as diagnostic targets, to identify relevant host counterparts, and to use this knowledge in developing or improving IVD. In this regard, an overlooked feature is the capacity of pathogens to adhere specifically to host cells and tissues. The molecular entities relevant for pathogen-surface interaction are the so-called adhesins. Adhesins vary from protein compounds to (poly-)saccharides or lipid structures that interact with eukaryotic host cell matrix molecules and receptors. Such interactions co-define the specificity and sensitivity of a diagnostic test. Currently, adhesin-receptor binding is typically used in the pre-analytical phase of IVD tests, focusing on pathogen enrichment. Further exploration of adhesin-ligand interaction, supported by present high-throughput \"omics\" technologies, might stimulate a new generation of broadly applicable pathogen detection and characterization tools. This review describes recent results of novel structure-defining technologies allowing for detailed molecular analysis of adhesins, their receptors and complexes. Since the host ligands evolve slowly, the corresponding adhesin interaction is under selective pressure to maintain a constant receptor binding domain. IVD should exploit such conserved binding sites and, in particular, use the human ligand to enrich the pathogen. We provide an inventory of methods based on adhesion factors and pathogen attachment mechanisms, which can also be of relevance to currently emerging pathogens, including SARS-CoV-2, the causative agent of COVID-19.", "doi": "10.3390/diagnostics11071259", "pmid": "34359341", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "diagnostics11071259"}, {"db": "pmc", "key": "PMC8305138"}], "notes": [], "created": "2021-08-11T14:37:57.779Z", "modified": "2021-08-11T14:37:57.951Z"}, {"entity": "publication", "iuid": "78b963daa11f420b89353538b366bd7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/78b963daa11f420b89353538b366bd7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/78b963daa11f420b89353538b366bd7e"}}, "title": "Fear and anxiety in the face of COVID-19: Negative dispositions towards risk and uncertainty as vulnerability factors.", "authors": [{"family": "Millroth", "given": "Philip", "initials": "P"}, {"family": "Frey", "given": "Renato", "initials": "R"}], "type": "journal article", "published": "2021-07-14", "journal": {"title": "J Anxiety Disord", "issn": "1873-7897", "issn-l": null, "volume": "83", "issue": null, "pages": "102454"}, "abstract": "In the face of the COVID-19 pandemic it is important to identify factors that make people particularly vulnerable of developing mental-health issues in order to provide case-specific treatments. In this article, we examine the roles of two psychological constructs - originally put forth in the behavioral decision sciences - in predicting interindividual differences in fear responses: general risk aversion (GRA) and intolerance of uncertainty (IU). We first provide a review of these constructs and illustrate why they may play important roles in shaping anxiety-related disorders. Thereafter we present an empirical study that collected survey data from 550 U.S. residents, comprising self-assessments of dispositions towards risk and uncertainty, anxiety- and depression levels, as well as demographic variables - to thus test the extent to which these psychological constructs are predictive of strong fear responses related to COVID-19 (i.e., mortal fear, racing heart). The results from Bayesian multi-model inference analyses showed that GRA and IU were more powerful predictors of fear responses than demographic variables. Moreover, the predictive power of these constructs was independent of general anxiety- and depression levels. Subsequent mediation analyses showed that the effects of GRA and IU were both direct and indirect via anxiety. We conclude by discussing possible treatment options, but also highlight that future research needs to further examine causal pathways and conceptual overlaps.", "doi": "10.1016/j.janxdis.2021.102454", "pmid": "34298237", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0887-6185(21)00101-8"}, {"db": "URL", "key": "https://osf.io/xb4ce/", "description": "Survey data"}], "notes": [], "created": "2021-08-05T07:07:49.825Z", "modified": "2021-11-18T09:14:45.531Z"}, {"entity": "publication", "iuid": "121e72cbf43f4f2fa38c2a5fb1a12997", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/121e72cbf43f4f2fa38c2a5fb1a12997.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/121e72cbf43f4f2fa38c2a5fb1a12997"}}, "title": "An international study on psychological coping during COVID-19: Towards a meaning-centered coping style.", "authors": [{"family": "Eisenbeck", "given": "Nikolett", "initials": "N"}, {"family": "Carreno", "given": "David F", "initials": "DF"}, {"family": "Wong", "given": "Paul T P", "initials": "PTP"}, {"family": "Hicks", "given": "Joshua A", "initials": "JA"}, {"family": "Mar\u00eda", "given": "Ru\u00edz-Ruano Garc\u00eda", "initials": "RG"}, {"family": "Puga", "given": "Jorge L", "initials": "JL"}, {"family": "Greville", "given": "James", "initials": "J"}, {"family": "Testoni", "given": "Ines", "initials": "I"}, {"family": "Biancalani", "given": "Gianmarco", "initials": "G"}, {"family": "L\u00f3pez", "given": "Ana Carla Cepeda", "initials": "ACC"}, {"family": "Villareal", "given": "Sof\u00eda", "initials": "S"}, {"family": "Enea", "given": "Violeta", "initials": "V"}, {"family": "Schulz-Quach", "given": "Christian", "initials": "C"}, {"family": "Jansen", "given": "Jonas", "initials": "J"}, {"family": "Sanchez-Ruiz", "given": "Maria-Jose", "initials": "M"}, {"family": "Y\u0131ld\u0131r\u0131m", "given": "Murat", "initials": "M"}, {"family": "Arslan", "given": "G\u00f6kmen", "initials": "G"}, {"family": "Cruz", "given": "Jos\u00e9 Fernando A", "initials": "JFA"}, {"family": "Sofia", "given": "Rui Manuel", "initials": "RM"}, {"family": "Ferreira", "given": "Maria Jos\u00e9", "initials": "MJ"}, {"family": "Ashraf", "given": "Farzana", "initials": "F"}, {"family": "W\u0105sowicz", "given": "Gra\u017cyna", "initials": "G"}, {"family": "Shalaby", "given": "Shahinaz M", "initials": "SM"}, {"family": "Amer", "given": "Reham A", "initials": "RA"}, {"family": "Yousfi", "given": "Hadda", "initials": "H"}, {"family": "Chukwuorji", "given": "JohnBosco Chika", "initials": "JC"}, {"family": "Guerra", "given": "Valeschka M", "initials": "VM"}, {"family": "Singh", "given": "Sandeep", "initials": "S"}, {"family": "Heintzelman", "given": "Samantha", "initials": "S"}, {"family": "Hutapea", "given": "Bonar", "initials": "B"}, {"family": "B\u00e9jaoui", "given": "Bouchara", "initials": "B"}, {"family": "Dash", "given": "Arobindu", "initials": "A"}, {"family": "Schlosser", "given": "Karoly Kornel", "initials": "KK"}, {"family": "Anniko", "given": "Malin K", "initials": "MK"}, {"family": "Rossa", "given": "Martin", "initials": "M"}, {"family": "Wongcharee", "given": "Hattaphan", "initials": "H"}, {"family": "Avsec", "given": "Andreja", "initials": "A"}, {"family": "Kocjan", "given": "Gaja Zager", "initials": "GZ"}, {"family": "Kav\u010di\u010d", "given": "Tina", "initials": "T"}, {"family": "Leontiev", "given": "Dmitry A", "initials": "DA"}, {"family": "Taranenko", "given": "Olga", "initials": "O"}, {"family": "Rasskazova", "given": "Elena", "initials": "E"}, {"family": "Maher", "given": "Elizabeth", "initials": "E"}, {"family": "Garc\u00eda-Montes", "given": "Jos\u00e9 Manuel", "initials": "JM"}], "type": "journal article", "published": "2021-07-14", "journal": {"title": "Int J Clin Health Psychol", "issn": "2174-0852", "issn-l": null, "volume": "22", "issue": "1", "pages": "100256"}, "abstract": "This study examined the role of different psychological coping mechanisms in mental and physical health during the initial phases of the COVID-19 crisis with an emphasis on meaning-centered coping.\r\n\r\nA total of 11,227 people from 30 countries across all continents participated in the study and completed measures of psychological distress (depression, stress, and anxiety), loneliness, well-being, and physical health, together with measures of problem-focused and emotion-focused coping, and a measure called the Meaning-centered Coping Scale (MCCS) that was developed in the present study. Validation analyses of the MCCS were performed in all countries, and data were assessed by multilevel modeling (MLM).\r\n\r\nThe MCCS showed a robust one-factor structure in 30 countries with good test-retest, concurrent and divergent validity results. MLM analyses showed mixed results regarding emotion and problem-focused coping strategies. However, the MCCS was the strongest positive predictor of physical and mental health among all coping strategies, independently of demographic characteristics and country-level variables.\r\n\r\nThe findings suggest that the MCCS is a valid measure to assess meaning-centered coping. The results also call for policies promoting effective coping to mitigate collective suffering during the pandemic.", "doi": "10.1016/j.ijchp.2021.100256", "pmid": "34429729", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1697-2600(21)00037-5"}, {"db": "pmc", "key": "PMC8355913"}], "notes": [], "created": "2021-08-27T09:36:53.616Z", "modified": "2021-11-18T09:03:19.676Z"}, {"entity": "publication", "iuid": "3dee1961748f40819892bf7be86fbd4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3dee1961748f40819892bf7be86fbd4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3dee1961748f40819892bf7be86fbd4d"}}, "title": "A pre/post analysis of the impact of the COVID-19 pandemic on the psychosocial work environment and recovery among healthcare workers in a large university hospital in Sweden.", "authors": [{"family": "Jonsdottir", "given": "Ingibj\u00f6rg H", "initials": "IH"}, {"family": "Degl'Innocenti", "given": "Alessio", "initials": "A"}, {"family": "Ahlstrom", "given": "Linda", "initials": "L"}, {"family": "Finizia", "given": "Caterina", "initials": "C"}, {"family": "Wijk", "given": "Helle", "initials": "H"}, {"family": "\u00c5kerstr\u00f6m", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-07-14", "journal": {"title": "J Public Health Res", "issn": "2279-9028", "issn-l": null}, "abstract": "The impact of the COVID-19 pandemic on workload, mental health, and well-being of healthcare workers, and particularly those on the front-line, has received considerable attention.\n\nWe surveyed hospital employees about their working environment during the pandemic and identified departments which were negatively affected in comparison to the pre-pandemic situation, as well as factors contributing to this. Setting and participants We surveyed all hospital employees at Sahlgrenska University Hospital, Sweden in September 2020 and compared results across departments and to the results of a large employee survey from October 2019.\n\nThe overall impact of the pandemic on perceived working conditions and possibility for recovery differed among departments. During the pandemic, healthcare workers working with COVID-19 patients reported poorer working environments than other employees. Factors significantly related to perception of work environment and recovery during the pandemic included worries of being infected, departmental transfer, and having insufficient access to personal protective equipment. Men reported better working conditions than women in all, but one item and higher age was related to better perceived working environment.\n\nOur results indicate that the pandemic differentially affects hospital departments and underscores the multifactorial nature of this topic. Contributing factors to poor perceived working environment could be addressed at times of high workload, such as during the pandemic, including providing appropriate support to managers, ensuring possibility for recovery during working hours, and acknowledging worries about infection. Young healthcare workers and staff who are relocated due to the pandemic warrant special attention.", "doi": "10.4081/jphr.2021.2329", "pmid": "34278769", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-05T11:12:31.477Z", "modified": "2021-08-05T11:12:31.489Z"}, {"entity": "publication", "iuid": "440e484854514d65875c54e966788b05", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/440e484854514d65875c54e966788b05.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/440e484854514d65875c54e966788b05"}}, "title": "Variant Analysis of SARS-CoV-2 Genomes from Belgian Military Personnel Engaged in Overseas Missions and Operations.", "authors": [{"family": "Pirnay", "given": "Jean-Paul", "initials": "JP", "orcid": "0000-0002-6863-5219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/57c49628604342ffae1231718cf6529e.json"}}, {"family": "Selhorst", "given": "Philippe", "initials": "P", "orcid": "0000-0002-4488-5790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a15ee083f17430aa249b4751f0b2002.json"}}, {"family": "Hong", "given": "Samuel L", "initials": "SL", "orcid": "0000-0001-6354-4943", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90a9fb0495604bb891f4fc786eca0a98.json"}}, {"family": "Cochez", "given": "Christel", "initials": "C"}, {"family": "Potter", "given": "Barney", "initials": "B"}, {"family": "Maes", "given": "Piet", "initials": "P"}, {"family": "Petrillo", "given": "Mauro", "initials": "M", "orcid": "0000-0002-6782-4704", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8183c35e5c7b40d1a7ea56a85521451b.json"}}, {"family": "Dudas", "given": "Gytis", "initials": "G", "orcid": "0000-0002-0227-4158", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/941f89c075f744219ea42f21be699871.json"}}, {"family": "Claes", "given": "Vincent", "initials": "V", "orcid": "0000-0001-6398-4009", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd75ac5e4f564a4f9feb651f1ecf4150.json"}}, {"family": "Van der Beken", "given": "Yolien", "initials": "Y"}, {"family": "Verbeken", "given": "Gilbert", "initials": "G"}, {"family": "Degueldre", "given": "Julie", "initials": "J"}, {"family": "Dellicour", "given": "Simon", "initials": "S", "orcid": "0000-0001-9558-1052", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35378313b42d4026a1deace84240c300.json"}}, {"family": "Cuypers", "given": "Lize", "initials": "L", "orcid": "0000-0002-9433-8752", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5fde6d7af1e406a83cc6284e285b473.json"}}, {"family": "T'Sas", "given": "France", "initials": "F"}, {"family": "Van den Eede", "given": "Guy", "initials": "G"}, {"family": "Verhasselt", "given": "Bruno", "initials": "B"}, {"family": "Weuts", "given": "Wouter", "initials": "W"}, {"family": "Smets", "given": "Cedric", "initials": "C"}, {"family": "Mertens", "given": "Jan", "initials": "J"}, {"family": "Geeraerts", "given": "Philippe", "initials": "P"}, {"family": "Ari\u00ebn", "given": "Kevin K", "initials": "KK"}, {"family": "Andr\u00e9", "given": "Emmanuel", "initials": "E"}, {"family": "Neirinckx", "given": "Pierre", "initials": "P"}, {"family": "Soentjens", "given": "Patrick", "initials": "P"}, {"family": "Baele", "given": "Guy", "initials": "G", "orcid": "0000-0002-1915-7732", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ed706bd4a744d8da6a2561880e98eba.json"}}], "type": "journal article", "published": "2021-07-13", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "7", "issn-l": "1999-4915"}, "abstract": "More than a year after the first identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as the causative agent of the 2019 coronavirus disease (COVID-19) in China, the emergence and spread of genomic variants of this virus through travel raise concerns regarding the introduction of lineages in previously unaffected regions, requiring adequate containment strategies. Concomitantly, such introductions fuel worries about a possible increase in transmissibility and disease severity, as well as a possible decrease in vaccine efficacy. Military personnel are frequently deployed on missions around the world. As part of a COVID-19 risk mitigation strategy, Belgian Armed Forces that engaged in missions and operations abroad were screened (7683 RT-qPCR tests), pre- and post-mission, for the presence of SARS-CoV-2, including the identification of viral lineages. Nine distinct viral genotypes were identified in soldiers returning from operations in Niger, the Democratic Republic of the Congo, Afghanistan, and Mali. The SARS-CoV-2 variants belonged to major clades 19B, 20A, and 20B (Nextstrain nomenclature), and included \"variant of interest\" B.1.525, \"variant under monitoring\" A.27, as well as lineages B.1.214, B.1, B.1.1.254, and A (pangolin nomenclature), some of which are internationally monitored due to the specific mutations they harbor. Through contact tracing and phylogenetic analysis, we show that isolation and testing policies implemented by the Belgian military command appear to have been successful in containing the influx and transmission of these distinct SARS-CoV-2 variants into military and civilian populations.", "doi": "10.3390/v13071359", "pmid": "34372565", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "v13071359"}], "notes": [], "created": "2021-08-11T14:32:26.858Z", "modified": "2021-08-11T14:33:04.232Z"}, {"entity": "publication", "iuid": "158d2c73662a4e4c9e3676dee6adb5e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/158d2c73662a4e4c9e3676dee6adb5e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/158d2c73662a4e4c9e3676dee6adb5e2"}}, "title": "Oxygen and Mortality in COVID-19 Pneumonia: A Comparative Analysis of Supplemental Oxygen Policies and Health Outcomes Across 26 Countries.", "authors": [{"family": "Mansab", "given": "Fatma", "initials": "F"}, {"family": "Donnelly", "given": "Harry", "initials": "H"}, {"family": "Kussner", "given": "Albrecht", "initials": "A"}, {"family": "Neil", "given": "James", "initials": "J"}, {"family": "Bhatti", "given": "Sohail", "initials": "S"}, {"family": "Goyal", "given": "Daniel K", "initials": "DK"}], "type": "journal article", "published": "2021-07-13", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "580585", "issn-l": "2296-2565"}, "abstract": "Introduction: Hypoxia is the main cause of morbidity and mortality in COVID-19. During the COVID-19 pandemic, some countries have reduced access to supplemental oxygen, whereas other nations have maintained and even improved access to supplemental oxygen. We examined whether variation in the nationally determined oxygen guidelines had any association with national mortality rates in COVID-19. Methods: Three independent investigators searched for, identified, and extracted the nationally recommended target oxygen levels for the commencement of oxygen in COVID-19 pneumonia from the 29 worst affected countries. Mortality estimates were calculated from three independent sources. We then applied both parametric (Pearson's R) and non-parametric (Kendall's Tau B) tests of bivariate association to determine the relationship between case fatality rate (CFR) and target SpO2, and also between potential confounders and CFR. Results: Of the 26 nations included, 15 had employed conservative oxygen strategies to manage COVID-19 pneumonia. Of them, Belgium, France, USA, Canada, China, Germany, Mexico, Spain, Sweden, and the UK guidelines advised commencing oxygen when oxygen saturations (SpO2) fell to 91% or less. A statistically significant correlation was found between SpO2 and CFR both parametrically (R = -0.53, P < 0.01) and non-parametrically (-0.474, P < 0.01). Conclusion: Our study highlights the disparity in oxygen provision for COVID-19 patients between the nations analysed. In those nations that pursued a conservative oxygen strategy, there was an association with higher national mortality rates. We discuss the potential reasons for such an association.", "doi": "10.3389/fpubh.2021.580585", "pmid": "34327182", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8313806"}], "notes": [], "created": "2021-08-04T17:04:55.055Z", "modified": "2021-08-04T17:05:02.692Z"}, {"entity": "publication", "iuid": "61e2ebaad09a477094041f730fbe213c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61e2ebaad09a477094041f730fbe213c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61e2ebaad09a477094041f730fbe213c"}}, "title": "Indications that Stockholm has reached herd immunity, given limited restrictions, against several variants of SARS-CoV-2", "authors": [{"family": "Carlsson", "given": "Marcus", "initials": "M", "orcid": "0000-0002-3761-9072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9492f80f98584a4c949a0114fb44ef71.json"}}, {"family": "S\u00f6derberg-Naucl\u00e9r", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-8955-3610", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f10026ba9a64bfea2fc49de969cdde9.json"}}], "type": "posted-content", "published": "2021-07-13", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.07.07.21260167", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-08-03T11:47:39.010Z", "modified": "2021-08-03T11:48:02.261Z"}, {"entity": "publication", "iuid": "8b75445e0d084e4690eb0ff93f85c84b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b75445e0d084e4690eb0ff93f85c84b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b75445e0d084e4690eb0ff93f85c84b"}}, "title": "COVID-19 Vaccines and Thrombosis-Roadblock or Dead-End Street?", "authors": [{"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Barh", "given": "Debmalya", "initials": "D", "orcid": "0000-0002-2557-7768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1de09014a90148069b6627b93ac71ea8.json"}}, {"family": "Uhal", "given": "Bruce D", "initials": "BD", "orcid": "0000-0002-5201-432X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d8004448df445bb86d5c733aa143e9b.json"}}, {"family": "Takayama", "given": "Kazuo", "initials": "K", "orcid": "0000-0002-1132-2457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de9286e534764113a02e6e51be237f86.json"}}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA", "orcid": "0000-0002-9519-6338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b9ca27af4d347c9b4097d3fd0ecf0bf.json"}}, {"family": "Abd El-Aziz", "given": "Tarek Mohamed", "initials": "TM", "orcid": "0000-0002-3441-9673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bd8ea28f1e24943b73f6d9e5d411aa3.json"}}, {"family": "Lal", "given": "Amos", "initials": "A", "orcid": "0000-0002-0021-2033", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf77b6a9233341f996b3ef515f41aa0f.json"}}, {"family": "Redwan", "given": "Elrashdy M", "initials": "EM", "orcid": "0000-0001-8246-0075", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf6f9cfd2f99436ea2eaecf2d83b07e9.json"}}, {"family": "Adadi", "given": "Parise", "initials": "P", "orcid": "0000-0003-4724-9463", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d2c862c9c1c4a1c8471708ae9628ef7.json"}}, {"family": "Chauhan", "given": "Gaurav", "initials": "G", "orcid": "0000-0002-5400-5638", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd1323f836244e91a37c69bb627cf0cd.json"}}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Azad", "given": "Gajendra Kumar", "initials": "GK", "orcid": "0000-0001-5478-526X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94c4f27a019d4cf2a9e459e6a914fa9c.json"}}, {"family": "Rezaei", "given": "Nima", "initials": "N", "orcid": "0000-0002-3836-1827", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/38c4c1dfbc464a1c8a08ab690568c6bd.json"}}, {"family": "Serrano-Aroca", "given": "\u00c1ngel", "initials": "\u00c1", "orcid": "0000-0002-9953-3848", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c8f520da33b429a8bc7eb19ff14f58d.json"}}, {"family": "Bazan", "given": "Nicolas G", "initials": "NG"}, {"family": "Hassan", "given": "Sk Sarif", "initials": "SS", "orcid": "0000-0003-4331-722X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c16068e54c442e580b4ba62905aa848.json"}}, {"family": "Panda", "given": "Pritam Kumar", "initials": "PK", "orcid": "0000-0003-4879-2302", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bbd0a928e33842a894bcb569549712c7.json"}}, {"family": "Pal Choudhury", "given": "Pabitra", "initials": "P"}, {"family": "Pizzol", "given": "Damiano", "initials": "D", "orcid": "0000-0003-4122-0774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b2b7ce8dc27462088eb836279b2d194.json"}}, {"family": "Kandimalla", "given": "Ramesh", "initials": "R", "orcid": "0000-0002-3313-4393", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5afbbf2e86e04041996b924b05b188f1.json"}}, {"family": "Baetas-da-Cruz", "given": "Wagner", "initials": "W"}, {"family": "Mishra", "given": "Yogendra Kumar", "initials": "YK", "orcid": "0000-0002-8786-9379", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4216dffbb5d04509b18c9f17fafee087.json"}}, {"family": "Palu", "given": "Giorgio", "initials": "G"}, {"family": "Brufsky", "given": "Adam M", "initials": "AM", "orcid": "0000-0001-8080-7960", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/869234cfbe6c42d5b0da85d4e9ee7464.json"}}, {"family": "Tambuwala", "given": "Murtaza M", "initials": "MM", "orcid": "0000-0001-8499-9891", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8ed708303c14ff8b1b3e9d1e60a4dfe.json"}}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN", "orcid": "0000-0002-4037-5857", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69478f3c84b7411fa4bb1c0043ce542b.json"}}], "type": "journal article", "published": "2021-07-13", "journal": {"title": "Biomolecules", "issn": "2218-273X", "volume": "11", "issue": "7", "issn-l": null}, "abstract": "Two adenovirus-based vaccines, ChAdOx1 nCoV-19 and Ad26.COV2.S, and two mRNA-based vaccines, BNT162b2 and mRNA.1273, have been approved by the European Medicines Agency (EMA), and are invaluable in preventing and reducing the incidence of coronavirus disease-2019 (COVID-19). Recent reports have pointed to thrombosis with associated thrombocytopenia as an adverse effect occurring at a low frequency in some individuals after vaccination. The causes of such events may be related to SARS-CoV-2 spike protein interactions with different C-type lectin receptors, heparan sulfate proteoglycans (HSPGs) and the CD147 receptor, or to different soluble splice variants of the spike protein, adenovirus vector interactions with the CD46 receptor or platelet factor 4 antibodies. Similar findings have been reported for several viral diseases after vaccine administration. In addition, immunological mechanisms elicited by viral vectors related to cellular delivery could play a relevant role in individuals with certain genetic backgrounds. Although rare, the potential COVID-19 vaccine-induced immune thrombotic thrombocytopenia (VITT) requires immediate validation, especially in risk groups, such as the elderly, chronic smokers, and individuals with pre-existing incidences of thrombocytopenia; and if necessary, a reformulation of existing vaccines.", "doi": "10.3390/biom11071020", "pmid": "34356644", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "biom11071020"}, {"db": "pmc", "key": "PMC8301964"}], "notes": [], "created": "2021-08-11T14:40:37.371Z", "modified": "2021-08-11T14:40:37.721Z"}, {"entity": "publication", "iuid": "36cf32d8e1f14ab3a9de2cef2a759e5f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/36cf32d8e1f14ab3a9de2cef2a759e5f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/36cf32d8e1f14ab3a9de2cef2a759e5f"}}, "title": "Blue Biotechnology: Computational Screening of Sarcophyton Cembranoid Diterpenes for SARS-CoV-2 Main Protease Inhibition.", "authors": [{"family": "Ibrahim", "given": "Mahmoud A A", "initials": "MAA", "orcid": "0000-0003-4819-2040", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/552195f5616e456b82fd45359b56f9c7.json"}}, {"family": "Abdelrahman", "given": "Alaa H M", "initials": "AHM", "orcid": "0000-0003-3527-0126", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89f2d2ac6ab343728c329fb71b4fa732.json"}}, {"family": "Atia", "given": "Mohamed A M", "initials": "MAM", "orcid": "0000-0003-2462-1269", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e973a0f11ca0459fa876c875fe3989cb.json"}}, {"family": "Mohamed", "given": "Tarik A", "initials": "TA", "orcid": "0000-0003-1639-3518", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69bfe5a2f846439dbea3d4d597546ec4.json"}}, {"family": "Moustafa", "given": "Mahmoud F", "initials": "MF"}, {"family": "Hakami", "given": "Abdulrahim R", "initials": "AR", "orcid": "0000-0003-2101-8800", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78ae225ce54745b489204cf1f3dd57c4.json"}}, {"family": "Khalifa", "given": "Shaden A M", "initials": "SAM"}, {"family": "Alhumaydhi", "given": "Fahad A", "initials": "FA", "orcid": "0000-0002-0151-8309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/575d134a229546749190bad9e2018ea1.json"}}, {"family": "Alrumaihi", "given": "Faris", "initials": "F", "orcid": "0000-0002-0850-5500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b60452d537bd43e1a01af011e03c5ea5.json"}}, {"family": "Abidi", "given": "Syed Hani", "initials": "SH", "orcid": "0000-0001-9497-0902", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/401fcf2d494a4afaafec85336c009b6b.json"}}, {"family": "Allemailem", "given": "Khaled S", "initials": "KS", "orcid": "0000-0002-6486-9835", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d53444ec5a8f4b15b4d1e455a9578733.json"}}, {"family": "Efferth", "given": "Thomas", "initials": "T"}, {"family": "Soliman", "given": "Mahmoud E", "initials": "ME"}, {"family": "Par\u00e9", "given": "Paul W", "initials": "PW", "orcid": "0000-0003-1644-723X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ac0f276b143475db0df390f50c8658b.json"}}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR", "orcid": "0000-0002-2519-6690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d35dc868deec44a69caa5ed9a65c15ce.json"}}, {"family": "Hegazy", "given": "Mohamed-Elamir F", "initials": "MF", "orcid": "0000-0002-0343-4969", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/efe074c3fdcc4601ba363cbdb84595bf.json"}}], "type": "journal article", "published": "2021-07-13", "journal": {"title": "Mar Drugs", "issn": "1660-3397", "volume": "19", "issue": "7", "issn-l": null}, "abstract": "The coronavirus pandemic has affected more than 150 million people, while over 3.25 million people have died from the coronavirus disease 2019 (COVID-19). As there are no established therapies for COVID-19 treatment, drugs that inhibit viral replication are a promising target; specifically, the main protease (Mpro) that process CoV-encoded polyproteins serves as an Achilles heel for assembly of replication-transcription machinery as well as down-stream viral replication. In the search for potential antiviral drugs that target Mpro, a series of cembranoid diterpenes from the biologically active soft-coral genus Sarcophyton have been examined as SARS-CoV-2 Mpro inhibitors. Over 360 metabolites from the genus were screened using molecular docking calculations. Promising diterpenes were further characterized by molecular dynamics (MD) simulations based on molecular mechanics-generalized Born surface area (MM-GBSA) binding energy calculations. According to in silico calculations, five cembranoid diterpenes manifested adequate binding affinities as Mpro inhibitors with \u0394Gbinding < -33.0 kcal/mol. Binding energy and structural analyses of the most potent Sarcophyton inhibitor, bislatumlide A (340), was compared to darunavir, an HIV protease inhibitor that has been recently subjected to clinical-trial as an anti-COVID-19 drug. In silico analysis indicates that 340 has a higher binding affinity against Mpro than darunavir with \u0394Gbinding values of -43.8 and -34.8 kcal/mol, respectively throughout 100 ns MD simulations. Drug-likeness calculations revealed robust bioavailability and protein-protein interactions were identified for 340; biochemical signaling genes included ACE, MAPK14 and ESR1 as identified based on a STRING database. Pathway enrichment analysis combined with reactome mining revealed that 340 has the capability to re-modulate the p38 MAPK pathway hijacked by SARS-CoV-2 and antagonize injurious effects. These findings justify further in vivo and in vitro testing of 340 as an antiviral agent against SARS-CoV-2.", "doi": "10.3390/md19070391", "pmid": "34356816", "labels": {"Category: Biochemistry": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "md19070391"}, {"db": "pmc", "key": "PMC8308023"}], "notes": [], "created": "2021-08-11T14:39:16.626Z", "modified": "2021-08-11T14:39:16.895Z"}, {"entity": "publication", "iuid": "bb24d0e5e1c24a38992eb445246d9f76", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb24d0e5e1c24a38992eb445246d9f76.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb24d0e5e1c24a38992eb445246d9f76"}}, "title": "Epidemiological characteristics and initial spatiotemporal visualisation of COVID-19 in a major city in the Middle East.", "authors": [{"family": "MohammadEbrahimi", "given": "Shahab", "initials": "S", "orcid": "0000-0002-1494-1544", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bdc10ef3b2e54ae18547877efaf5c000.json"}}, {"family": "Mohammadi", "given": "Alireza", "initials": "A", "orcid": "0000-0002-3327-0942", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f5101616a2d41468b9a706f743f49b3.json"}}, {"family": "Bergquist", "given": "Robert", "initials": "R", "orcid": "0000-0002-0190-1084", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78ef78e2b8334cb99d848a429434cfb5.json"}}, {"family": "Dolatkhah", "given": "Fatemeh", "initials": "F", "orcid": "0000-0002-8342-6618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77db8d4308024e9e86b854718b579739.json"}}, {"family": "Olia", "given": "Mahsa", "initials": "M", "orcid": "0000-0002-5013-7000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e84399127f9b4ba48b884b3ca9e9e4dd.json"}}, {"family": "Tavakolian", "given": "Ayoub", "initials": "A", "orcid": "0000-0002-4884-8524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69886ea0ac0547e0b85f16b91b3d3f41.json"}}, {"family": "Pishgar", "given": "Elahe", "initials": "E", "orcid": "0000-0001-7217-2598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac8cf4f85ea34ad297a6343ef7bc4044.json"}}, {"family": "Kiani", "given": "Behzad", "initials": "B", "orcid": "0000-0002-8816-328X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c30601593bd54510866e077ade6765d0.json"}}], "type": "journal article", "published": "2021-07-12", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "1373"}, "abstract": "The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) emerged initially in China in December 2019 causing the COVID-19 disease, which quickly spread worldwide. Iran was one of the first countries outside China to be affected in a major way and is now under the spell of a fourth wave. This study aims to investigate the epidemiological characteristics of COVID-19 cases in north-eastern Iran through mapping the spatiotemporal trend of the disease.\r\n\r\nThe study comprises data of 4000 patients diagnosed by laboratory assays or clinical investigation from the beginning of the disease on Feb 14, 2020, until May 11, 2020. Epidemiological features and spatiotemporal trends of the disease in the study area were explored by classical statistical approaches and Geographic Information Systems.\r\n\r\nMost common symptoms were dyspnoea (69.4%), cough (59.4%), fever (54.4%) and weakness (19.5%). Approximately 82% of those who did not survive suffered from dyspnoea. The highest Case Fatality Rate (CFR) was related to those with cardiovascular disease (27.9%) and/or diabetes (18.1%). Old age (\u226560 years) was associated with an almost five-fold increased CFR. Odds Ratio (OR) showed malignancy (3.8), nervous diseases (2.2), and respiratory diseases (2.2) to be significantly associated with increased CFR with developments, such as hospitalization at the ICU (2.9) and LOS (1.1) also having high correlations. Furthermore, spatial analyses revealed a geographical pattern in terms of both incidence and mortality rates, with COVID-19 first being observed in suburban areas from where the disease swiftly spread into downtown reaching a peak between 25 February to 06 March (4 incidences per km2). Mortality peaked 3 weeks later after which the infection gradually decreased. Out of patients investigated by the spatiotemporal approach (n = 727), 205 (28.2%) did not survive and 66.8% of them were men.\r\n\r\nOlder adults and people with severe co-morbidities were at higher risk for developing serious complications due to COVID-19. Applying spatiotemporal methods to identify the transmission trends and high-risk areas can rapidly be documented, thereby assisting policymakers in designing and implementing tailored interventions to control and prevent not only COVID-19 but also other rapidly spreading epidemics/pandemics.", "doi": "10.1186/s12889-021-11326-2", "pmid": "34247616", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11326-2"}, {"db": "pmc", "key": "PMC8272989"}], "notes": [], "created": "2021-08-06T07:49:43.922Z", "modified": "2021-11-18T08:58:58.477Z"}, {"entity": "publication", "iuid": "38586f75de7947afa759f06f240e3a9b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38586f75de7947afa759f06f240e3a9b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38586f75de7947afa759f06f240e3a9b"}}, "title": "Comparison of online learning designs during the COVID-19 pandemic within bioinformatics courses in higher education.", "authors": [{"family": "Abrahamsson", "given": "Sanna", "initials": "S"}, {"family": "D\u00e1vila L\u00f3pez", "given": "Marcela", "initials": "M"}], "type": "journal article", "published": "2021-07-12", "journal": {"title": "Bioinformatics", "issn": "1367-4811", "volume": "37", "issue": "Suppl_1", "pages": "i9-i15", "issn-l": null}, "abstract": "Due to the worldwide COVID-19 pandemic, new strategies had to be adopted to move from classroom-based education to online education, in a very short time. The lack of time to set up these strategies, hindered a proper design of online instructions and delivery of knowledge. Bioinformatics-related training and other onsite practical education, tend to rely on extensive practice, where students and instructors have a face-to-face interaction to improve the learning outcome. For these courses to maintain their high quality when adapted as online courses, different designs need to be tested and the students' perceptions need to be heard.\n\nThis study focuses on short bioinformatics-related courses for graduate students at the University of Gothenburg, Sweden, which were originally developed for onsite training. Once adapted as online courses, several modifications in their design were tested to obtain the best fitting learning strategy for the students. To improve the online learning experience, we propose a combination of: (i) short synchronized sessions, (ii) extended time for own and group practical work, (iii) recorded live lectures and (iv) increased opportunities for feedback in several formats.\n\nSupplementary data are available at Bioinformatics online.", "doi": "10.1093/bioinformatics/btab304", "pmid": "34252967", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "6319705"}], "notes": [], "created": "2021-08-06T07:36:14.851Z", "modified": "2021-08-06T07:48:18.065Z"}, {"entity": "publication", "iuid": "d2b62737826f4a37af9872b0e5c8caf6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d2b62737826f4a37af9872b0e5c8caf6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d2b62737826f4a37af9872b0e5c8caf6"}}, "title": "Study of SARS-CoV-2 transmission in urban environment by questionnaire and modeling for sustainable risk control.", "authors": [{"family": "Yu", "given": "Han", "initials": "H"}, {"family": "Ye", "given": "Xuying", "initials": "X"}, {"family": "Zhang", "given": "Minying", "initials": "M"}, {"family": "Zhang", "given": "Fenghao", "initials": "F"}, {"family": "Li", "given": "Yao", "initials": "Y"}, {"family": "Pan", "given": "Suxun", "initials": "S"}, {"family": "Li", "given": "Yuanling", "initials": "Y"}, {"family": "Yu", "given": "Hongbing", "initials": "H"}, {"family": "Lu", "given": "Chengzhi", "initials": "C"}], "type": "journal article", "published": "2021-07-10", "journal": {"title": "J Hazard Mater", "issn": "1873-3336", "issn-l": null, "volume": "420", "issue": null, "pages": "126621"}, "abstract": "Caused by SARS-CoV-2, COVID-19 has become a severe threaten to society and human health, its epidemic control emerges as long-term issue. A sustainable epidemic and environmental transmission risk control (SEERC) in urban area is urgently needed. This work aims to conduct a new investigation on the transmission risk of SARS-COV-2 as virus/hazardous material through various environmental medias, routes and regions in the entirely urban area for guiding the SEERC. Specifically, 5 routes in 28 regions (totally 140 scenarios) are considered. For a new perspective, the risk evaluation is conducted by the quantification of frontline medicals staffs' valuable experience in this work. 207 specialists responsible for the treatment of over 9000 infected patients are involved. The result showed that degree of risk was in the order of breath>contact-to-object>contact-to-human>intake>unknown. The modeling suggested source control as the prior measure for epidemic control. The combination of source control & mask wearing showed high efficiency in SEERC. The homeworking policy needed to cooperate with activity limitation to perform its efficiency. Subsequently, a new plan for SEERC was discussed. This work delivered significant information to researchers and decision makers for the further development of sustainable control for SARS-COV-2 spreading and COVID-19 epidemic.", "doi": "10.1016/j.jhazmat.2021.126621", "pmid": "34274804", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0304-3894(21)01586-7"}, {"db": "pmc", "key": "PMC8270745"}], "notes": [], "created": "2021-08-05T11:14:26.544Z", "modified": "2021-11-18T08:56:25.353Z"}, {"entity": "publication", "iuid": "f3652b085fec4a67a2878ce58ccfbbe6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f3652b085fec4a67a2878ce58ccfbbe6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f3652b085fec4a67a2878ce58ccfbbe6"}}, "title": "The one-sided explanations of a multifactorial coronavirus disease.", "authors": [{"family": "Ros\u00e9n", "given": "M\u00e5ns", "initials": "M", "orcid": "0000-0001-5295-0014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d544032f8b1c4fa1991916eda98aa5b9.json"}}, {"family": "Stenbeck", "given": "David", "initials": "D"}, {"family": "Stenbeck", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-07-09", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "14034948211026540", "issn-l": "1403-4948"}, "abstract": "Short-term interventions to suppress COVID-19 completely dominate the public, political and even the professional discussion on what explains observed differences in mortality and morbidity across countries. This leads to an exaggerated view of what such measures can accomplish. Factors such as housing and social conditions as well as travel patterns are equally important but neglected aspects of the COVID-19 development. A multifactorial disease needs a multivariate analytical approach.", "doi": "10.1177/14034948211026540", "pmid": "34240648", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:59:17.642Z", "modified": "2021-08-06T07:59:17.682Z"}, {"entity": "publication", "iuid": "19f38ab941cf4bbfb971c9e6fab34798", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19f38ab941cf4bbfb971c9e6fab34798.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19f38ab941cf4bbfb971c9e6fab34798"}}, "title": "The good, the bad and the ugly of children\u00b4s screen time during the COVID-19 pandemic.", "authors": [{"family": "Korhonen", "given": "Laura", "initials": "L", "orcid": "0000-0002-1837-5930", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a549aa5146734b40bd08f5f48a0ab366.json"}}], "type": "editorial", "published": "2021-07-09", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253"}, "abstract": null, "doi": "10.1111/apa.16012", "pmid": "34245034", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:52:35.947Z", "modified": "2021-08-06T07:56:46.829Z"}, {"entity": "publication", "iuid": "b97b058da45f40cd9d8bf05fd0f5bda9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b97b058da45f40cd9d8bf05fd0f5bda9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b97b058da45f40cd9d8bf05fd0f5bda9"}}, "title": "Self-Exclusion from Gambling-A Measure of COVID-19 Impact on Gambling in a Highly Online-Based Gambling Market?", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A", "orcid": "0000-0002-5800-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec14ecdcc0654d8ea864f64ce195752b.json"}}, {"family": "Widinghoff", "given": "Carolina", "initials": "C"}, {"family": "Berge", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2021-07-09", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "14", "pages": null}, "abstract": "The COVID-19 pandemic, and related changes of the gambling market, have been suspected to affect the risk of problem gambling. Despite media attention and political concern with this risk, study findings hitherto have been mixed. Voluntary self-exclusion from gambling was introduced on a national level in Sweden as a harm reduction tool in 2019, and this self-exclusion service in Sweden is a rare example of such an official, nationwide, multi-operator system. The present study aimed to evaluate whether short-term self-exclusion patterns were affected by different phases of COVID-19-related impacts on gambling markets in 2020. During the lock-down of sports in the spring months of 2020, three-month self-exclusion was unaffected, and one-month self-exclusion appeared to increase, though not more than in a recent period prior to COVID-19. Despite large differences in sports betting practices between women and men, self-exclusion patterns during COVID-19 were not apparently gender-specific. Altogether, self-exclusion from gambling, to date, does not appear to be affected by COVID-19-related changes in society, in contrast with beliefs about such changes producing greater help-seeking behavior in gamblers. Limitations are discussed, including the fact that in a recently introduced system, seasonality aspects and the autocorrelated nature of the data made substantial statistical measures unfeasible.", "doi": "10.3390/ijerph18147367", "pmid": "34299817", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph18147367"}, {"db": "pmc", "key": "PMC8305751"}], "notes": [], "created": "2021-08-05T07:07:30.294Z", "modified": "2021-11-18T08:54:37.444Z"}, {"entity": "publication", "iuid": "0bc0e45ee27f43388eea0bea6188ba6e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0bc0e45ee27f43388eea0bea6188ba6e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0bc0e45ee27f43388eea0bea6188ba6e"}}, "title": "Schools closed due to COVID-19 pandemic can be reopened early and safely.", "authors": [{"family": "Milerad", "given": "Josef", "initials": "J", "orcid": "0000-0003-1775-4602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/57d6b75491ed49a18ada88ae9d46e0a6.json"}}], "type": "editorial", "published": "2021-07-09", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253"}, "abstract": null, "doi": "10.1111/apa.16010", "pmid": "34245052", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:51:14.722Z", "modified": "2021-08-06T07:56:22.741Z"}, {"entity": "publication", "iuid": "3182957ca98c4962886b0eda0c9205a3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3182957ca98c4962886b0eda0c9205a3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3182957ca98c4962886b0eda0c9205a3"}}, "title": "Gender-specific estimates of sleep problems during the COVID-19 pandemic: Systematic review and meta-analysis.", "authors": [{"family": "Alimoradi", "given": "Zainab", "initials": "Z"}, {"family": "Gozal", "given": "David", "initials": "D"}, {"family": "Tsang", "given": "Hector W H", "initials": "HWH"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A", "orcid": "0000-0002-0433-0619", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07e3a9fa06004152bb4f194f4d2d1d8c.json"}}, {"family": "Ohayon", "given": "Maurice M", "initials": "MM"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-07-09", "journal": {"title": "J Sleep Res", "issn": "1365-2869", "issn-l": "0962-1105", "volume": null, "issue": null, "pages": "e13432"}, "abstract": "The outbreak of the novel coronavirus disease 2019 (COVID-19) changed lifestyles worldwide and subsequently induced individuals' sleep problems. Sleep problems have been demonstrated by scattered evidence among the current literature on COVID-19; however, little is known regarding the synthesised prevalence of sleep problems (i.e. insomnia symptoms and poor sleep quality) for males and females separately. The present systematic review and meta-analysis aimed to answer the important question regarding prevalence of sleep problems during the COVID-19 outbreak period between genders. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline and Newcastle-Ottawa Scale checklist, relevant studies with satisfactory methodological quality searched for in five academic databases (Scopus, PubMed Central, ProQuest, Web of Science , and EMBASE) were included and analysed. The protocol of the project was registered in the International Prospective Register of Systematic Reviews (PROSPERO; identification code CRD42020181644). A total of 54 papers (N = 67,722) in the female subgroup and 45 papers (N = 45,718) in the male subgroup were pooled in the meta-analysis. The corrected pooled estimated prevalence of sleep problems was 24% (95% confidence interval [CI] 19%-29%) for female participants and 27% (95% CI 24%-30%) for male participants. Although in both gender subgroups, patients with COVID-19, health professionals and general population showed the highest prevalence of sleep problems, it did not reach statistical significance. Based on multivariable meta-regression, both gender groups had higher prevalence of sleep problems during the lockdown period. Therefore, healthcare providers should pay attention to the sleep problems and take appropriate preventive action.", "doi": "10.1111/jsr.13432", "pmid": "34245055", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:50:54.687Z", "modified": "2021-11-18T08:51:42.937Z"}, {"entity": "publication", "iuid": "823bb9f54aa14eff88ccb2d6880fa2d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/823bb9f54aa14eff88ccb2d6880fa2d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/823bb9f54aa14eff88ccb2d6880fa2d7"}}, "title": "Development and validation of a tool to appraise guidelines on SARS-CoV-2 infection control strategies in healthcare workers.", "authors": [{"family": "Subramaniam", "given": "Ashwin", "initials": "A"}, {"family": "Ponnapa Reddy", "given": "Mallikarjuna", "initials": "M"}, {"family": "Kadam", "given": "Umesh", "initials": "U"}, {"family": "Zubarev", "given": "Alexander", "initials": "A"}, {"family": "Lim", "given": "Zheng", "initials": "Z"}, {"family": "Anstey", "given": "Chris", "initials": "C"}, {"family": "Bihari", "given": "Shailesh", "initials": "S"}, {"family": "Haji", "given": "Jumana", "initials": "J"}, {"family": "Luo", "given": "Jinghang", "initials": "J"}, {"family": "Mitra", "given": "Saikat", "initials": "S"}, {"family": "Ramanathan", "given": "Kollengode", "initials": "K"}, {"family": "Rajamani", "given": "Arvind", "initials": "A"}, {"family": "Rubulotta", "given": "Francesca", "initials": "F"}, {"family": "Svensk", "given": "Erik", "initials": "E"}, {"family": "Shekar", "given": "Kiran", "initials": "K"}], "type": "journal article", "published": "2021-07-09", "journal": {"title": "Aust Crit Care", "issn": "1036-7314", "issn-l": null}, "abstract": "Clinical guidelines on infection control strategies in healthcare workers (HCWs) play an important role in protecting them during the severe acute respiratory syndrome coronavirus 2 pandemic. Poorly constructed guidelines that are incomprehensive and/or ambiguous may compromise HCWs' safety.\n\nThe objective of this study was to develop and validate a tool to appraise guidelines on infection control strategies in HCWs based on the guidelines published early in the coronavirus disease 2019 pandemic.\n\nA three-stage, web-based, Delphi consensus-building process among a panel of diverse HCWs and healthcare managers was performed. The tool was validated by appraising 40 international, specialty-specific, and procedure-specific guidelines along with national guidelines from countries with a wide range of gross national income.\n\nOverall consensus (\u226575%) was reached at the end of three rounds for all six domains included in the tool. The Delphi panel recommended an ideal infection control guideline should encompass six domains: general characteristics (domain 1), engineering recommendations (domain 2), personal protective equipment (PPE) use (domain 3), and administrative aspects (domain 4-6) of infection control. The appraisal tool performed well across the six domains, and the inter-rater agreement was excellent for the 40 guidelines. All included guidelines performed relatively better in domains 1-3 than in domains 4-6, and this was more evident in guidelines originating from lower income countries.\n\nThe guideline appraisal tool was robust and easy to use. Engineering recommendations aspects of infection control, administrative measures that promote optimal PPE use, and HCW wellbeing were generally lacking in assessed guidelines. This tool may enable health systems to adopt high-quality HCW infection control guidelines during the severe acute respiratory syndrome coronavirus 2 pandemic and may also provide a framework for future guideline development.", "doi": "10.1016/j.aucc.2021.06.015", "pmid": "34404579", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1036-7314(21)00109-0"}], "notes": [], "created": "2021-08-20T12:22:10.265Z", "modified": "2021-08-20T12:22:34.716Z"}, {"entity": "publication", "iuid": "75228cad4a604941871dc8aa3b32d156", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/75228cad4a604941871dc8aa3b32d156.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/75228cad4a604941871dc8aa3b32d156"}}, "title": "Correction to 'Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy'.", "authors": [{"family": "Wacker", "given": "Anna", "initials": "A"}, {"family": "Weigand", "given": "Julia E", "initials": "JE", "orcid": "0000-0003-4247-1348", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5229ec08ce9242c19049804ff8a77085.json"}}, {"family": "Akabayov", "given": "Sabine R", "initials": "SR"}, {"family": "Altincekic", "given": "Nadide", "initials": "N"}, {"family": "Bains", "given": "Jasleen Kaur", "initials": "JK"}, {"family": "Banijamali", "given": "Elnaz", "initials": "E"}, {"family": "Binas", "given": "Oliver", "initials": "O"}, {"family": "Castillo-Martinez", "given": "Jesus", "initials": "J"}, {"family": "Cetiner", "given": "Erhan", "initials": "E"}, {"family": "Ceylan", "given": "Bet\u00fcl", "initials": "B"}, {"family": "Chiu", "given": "Liang-Yuan", "initials": "LY"}, {"family": "Davila-Calderon", "given": "Jesse", "initials": "J"}, {"family": "Dhamotharan", "given": "Karthikeyan", "initials": "K"}, {"family": "Duchardt-Ferner", "given": "Elke", "initials": "E"}, {"family": "Ferner", "given": "Jan", "initials": "J"}, {"family": "Frydman", "given": "Lucio", "initials": "L"}, {"family": "F\u00fcrtig", "given": "Boris", "initials": "B", "orcid": "0000-0001-6443-7656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5e0849167334290a5bd6691644783bf.json"}}, {"family": "Gallego", "given": "Jos\u00e9", "initials": "J", "orcid": "0000-0002-0627-6927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b188371610a46858542181b11863966.json"}}, {"family": "Gr\u00fcn", "given": "J Tassilo", "initials": "JT"}, {"family": "Hacker", "given": "Carolin", "initials": "C"}, {"family": "Haddad", "given": "Christina", "initials": "C"}, {"family": "H\u00e4hnke", "given": "Martin", "initials": "M"}, {"family": "Hengesbach", "given": "Martin", "initials": "M", "orcid": "0000-0001-9414-1602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa75083441294b4f8fe68b1a42fee601.json"}}, {"family": "Hiller", "given": "Fabian", "initials": "F"}, {"family": "Hohmann", "given": "Katharina F", "initials": "KF"}, {"family": "Hymon", "given": "Daniel", "initials": "D"}, {"family": "de Jesus", "given": "Vanessa", "initials": "V"}, {"family": "Jonker", "given": "Henry", "initials": "H"}, {"family": "Keller", "given": "Heiko", "initials": "H"}, {"family": "Knezic", "given": "Bozana", "initials": "B"}, {"family": "Landgraf", "given": "Tom", "initials": "T"}, {"family": "L\u00f6hr", "given": "Frank", "initials": "F"}, {"family": "Luo", "given": "Le", "initials": "L"}, {"family": "Mertinkus", "given": "Klara R", "initials": "KR"}, {"family": "Muhs", "given": "Christina", "initials": "C"}, {"family": "Novakovic", "given": "Mihajlo", "initials": "M"}, {"family": "Oxenfarth", "given": "Andreas", "initials": "A"}, {"family": "Palomino-Sch\u00e4tzlein", "given": "Martina", "initials": "M"}, {"family": "Petzold", "given": "Katja", "initials": "K"}, {"family": "Peter", "given": "Stephen A", "initials": "SA"}, {"family": "Pyper", "given": "Dennis J", "initials": "DJ"}, {"family": "Qureshi", "given": "Nusrat S", "initials": "NS"}, {"family": "Riad", "given": "Magdalena", "initials": "M"}, {"family": "Richter", "given": "Christian", "initials": "C"}, {"family": "Saxena", "given": "Krishna", "initials": "K"}, {"family": "Schamber", "given": "Tatjana", "initials": "T"}, {"family": "Scherf", "given": "Tali", "initials": "T"}, {"family": "Schlagnitweit", "given": "Judith", "initials": "J"}, {"family": "Schlundt", "given": "Andreas", "initials": "A", "orcid": "0000-0003-2254-7560", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/662b48aa496e4109aab02871f6b1d43d.json"}}, {"family": "Schnieders", "given": "Robbin", "initials": "R"}, {"family": "Schwalbe", "given": "Harald", "initials": "H", "orcid": "0000-0001-5693-7909", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32641f04b8504ac493d46947e87e4f59.json"}}, {"family": "Simba-Lahuasi", "given": "Alvaro", "initials": "A"}, {"family": "Sreeramulu", "given": "Sridhar", "initials": "S"}, {"family": "Stirnal", "given": "Elke", "initials": "E"}, {"family": "Sudakov", "given": "Alexey", "initials": "A"}, {"family": "Tants", "given": "Jan-Niklas", "initials": "JN"}, {"family": "Tolbert", "given": "Blanton S", "initials": "BS"}, {"family": "V\u00f6gele", "given": "Jennifer", "initials": "J"}, {"family": "Wei\u00df", "given": "Lena", "initials": "L"}, {"family": "Wirmer-Bartoschek", "given": "Julia", "initials": "J"}, {"family": "Wirtz Martin", "given": "Maria A", "initials": "MA"}, {"family": "W\u00f6hnert", "given": "Jens", "initials": "J", "orcid": "0000-0001-7193-401X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/611eebfc08f54e20b4dc9b881da010b8.json"}}, {"family": "Zetzsche", "given": "Heidi", "initials": "H"}], "type": "published erratum", "published": "2021-07-09", "journal": {"title": "Nucleic Acids Res", "issn": "1362-4962", "volume": "49", "issue": "12", "pages": "7204-7205", "issn-l": "0305-1048"}, "abstract": null, "doi": "10.1093/nar/gkab568", "pmid": "34161581", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8266613"}, {"db": "pii", "key": "6308495"}], "notes": [], "created": "2021-06-28T18:17:42.332Z", "modified": "2023-06-19T15:30:50.411Z"}, {"entity": "publication", "iuid": "d079fcc4919b45aba6636d41ad1bfaa8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d079fcc4919b45aba6636d41ad1bfaa8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d079fcc4919b45aba6636d41ad1bfaa8"}}, "title": "Baricitinib reduces 30-day mortality in older adults with moderate-to-severe COVID-19 pneumonia.", "authors": [{"family": "Abizanda", "given": "Pedro", "initials": "P"}, {"family": "Calbo Mayo", "given": "Juan Mar\u00eda", "initials": "JM"}, {"family": "Mas Romero", "given": "Marta", "initials": "M"}, {"family": "Cort\u00e9s Zamora", "given": "Elisa Bel\u00e9n", "initials": "EB"}, {"family": "Tabernero Sahuquillo", "given": "Mar\u00eda Teresa", "initials": "MT"}, {"family": "Romero Rizos", "given": "Luis", "initials": "L"}, {"family": "S\u00e1nchez-Jurado", "given": "Pedro Manuel", "initials": "PM"}, {"family": "S\u00e1nchez-Nievas", "given": "Gin\u00e9s", "initials": "G"}, {"family": "Campayo Escolano", "given": "Carlos", "initials": "C"}, {"family": "Ochoa Serrano", "given": "Alba", "initials": "A"}, {"family": "S\u00e1nchez-Flor Alfaro", "given": "Victoria", "initials": "V"}, {"family": "L\u00f3pez Bru", "given": "Rita", "initials": "R"}, {"family": "G\u00f3mez Ballesteros", "given": "Cristina", "initials": "C"}, {"family": "Caldevilla Bernardo", "given": "David", "initials": "D"}, {"family": "Callejas Gonz\u00e1lez", "given": "Francisco Javier", "initials": "FJ"}, {"family": "Andr\u00e9s-Pretel", "given": "Fernando", "initials": "F"}, {"family": "Lauschke", "given": "Volker Martin", "initials": "VM"}, {"family": "Stebbing", "given": "Justin", "initials": "J"}], "type": "journal article", "published": "2021-07-08", "journal": {"title": "J Am Geriatr Soc", "issn": "0002-8614", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Older adults are at the highest risk of severe disease and death due to COVID-19. Randomized data have shown that baricitinib improves outcomes in these patients, but focused stratified analyses of geriatric cohorts are lacking. Our objective was to analyze the efficacy of baricitinib in older adults with COVID-19 moderate-to-severe pneumonia.\r\n\r\nThis is a propensity score [PS]-matched retrospective cohort study. Patients from the COVID-AGE and Alba-Score cohorts, hospitalized for moderate-to-severe COVID-19 pneumonia, were categorized in two age brackets of age <70 years old (86 with baricitinib and 86 PS-matched controls) or \u226570 years old (78 on baricitinib and 78 PS-matched controls). Thirty-day mortality rates were analyzed with Kaplan-Meier and Cox proportional hazard models.\r\n\r\nMean age was 79.1 for those \u226570 years and 58.9 for those <70. Exactly 29.6% were female. Treatment with baricitinib resulted in a significant reduction in death from any cause by 48% in patients aged 70 or older, an 18.5% reduction in 30-day absolute mortality risk (n/N: 16/78 [20.5%] baricitinib, 30/78 [38.5%] in PS-matched controls, p < 0.001) and a lower 30-day adjusted fatality rate (HR 0.21; 95% CI 0.09-0.47; p < 0.001). Beneficial effects on mortality were also observed in the age group <70 (8.1% reduction in 30-day absolute mortality risk; HR 0.14; 95% CI 0.03-0.64; p = 0.011).\r\n\r\nBaricitinib is associated with an absolute mortality risk reduction of 18.5% in adults older than 70 years hospitalized with COVID-19 pneumonia.", "doi": "10.1111/jgs.17357", "pmid": "34235720", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-06T08:21:28.943Z", "modified": "2021-08-23T14:38:39.781Z"}, {"entity": "publication", "iuid": "f36f197d53a64a43902196bf0722814e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f36f197d53a64a43902196bf0722814e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f36f197d53a64a43902196bf0722814e"}}, "title": "Swedish nationwide time series analysis of influenza and suicide deaths from 1910 to 1978.", "authors": [{"family": "R\u00fcck", "given": "Christian", "initials": "C", "orcid": "0000-0002-8742-0168", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1183965f649f4bf08e86186f5ec30519.json"}}, {"family": "Mataix-Cols", "given": "David", "initials": "D"}, {"family": "Malki", "given": "Kinda", "initials": "K"}, {"family": "Adler", "given": "Mats", "initials": "M"}, {"family": "Flygare", "given": "Oskar", "initials": "O", "orcid": "0000-0002-2017-3940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b7ed40871394a0d993b094b809a1e70.json"}}, {"family": "Runeson", "given": "Bo", "initials": "B"}, {"family": "Sidorchuk", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-07-07", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "7", "pages": "e049302"}, "abstract": "There is concern that the COVID-19 pandemic will be associated with an increase in suicides, but evidence supporting a link between pandemics and suicide is limited. Using data from the three influenza pandemics of the 20th century, we aimed to investigate whether an association exists between influenza deaths and suicide deaths.\r\n\r\nTime series analysis.\r\n\r\nSweden.\r\n\r\nDeaths from influenza and suicides extracted from the Statistical Yearbook of Sweden for 1910-1978, covering three pandemics (the Spanish influenza, the Asian influenza and the Hong Kong influenza).\r\n\r\nAnnual suicide rates in Sweden among the whole population, men and women. Non-linear autoregressive distributed lag models was implemented to explore if there is a short-term and/or long-term relationship of increases and decreases in influenza death rates with suicide rates during 1910-1978.\r\n\r\nBetween 1910 and 1978, there was no evidence of either short-term or long-term significant associations between influenza death rates and changes in suicides (\u03b2 coefficients of 0.00002, p=0.931 and \u03b2=0.00103, p=0.764 for short-term relationship of increases and decreases in influenza death rates, respectively, with suicide rates, and \u03b2=-0.0002, p=0.998 and \u03b2=0.00211, p=0.962 for long-term relationship of increases and decreases in influenza death rates, respectively, with suicide rates). The same pattern emerged in separate analyses for men and women.\r\n\r\nWe found no evidence of short-term or long-term association between influenza death rates and suicide death rates across three 20th century pandemics.", "doi": "10.1136/bmjopen-2021-049302", "pmid": "34233997", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-049302"}, {"db": "pmc", "key": "PMC8266430"}, {"db": "URL", "key": "https://bmjopen.bmj.com/content/bmjopen/suppl/2021/07/07/bmjopen-2021-049302.DC1/bmjopen-2021-049302supp001_data_supplement.pdf", "description": "Numbers of deaths by influenza and suicide and total population for 1910-1978"}], "notes": [], "created": "2021-08-06T08:30:29.374Z", "modified": "2021-11-18T08:47:06.477Z"}, {"entity": "publication", "iuid": "cd0c0576dfbd45aba076d15ccad48f58", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd0c0576dfbd45aba076d15ccad48f58.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd0c0576dfbd45aba076d15ccad48f58"}}, "title": "Demographic and clinical characteristics of severe Covid-19 infections: a cross-sectional study from Mashhad University of Medical Sciences, Iran.", "authors": [{"family": "Goshayeshi", "given": "Ladan", "initials": "L"}, {"family": "Akbari Rad", "given": "Mina", "initials": "M"}, {"family": "Bergquist", "given": "Robert", "initials": "R"}, {"family": "Allahyari", "given": "Abolghasem", "initials": "A"}, {"family": "Hashemzadeh", "given": "Kamila", "initials": "K"}, {"family": "MUMS Covid-19 Research Team", "given": "", "initials": ""}, {"family": "Hoseini", "given": "Benyamin", "initials": "B", "orcid": "0000-0002-0355-6181", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a56dc3b14f8430fa3f011ef206976f4.json"}}], "type": "journal article", "published": "2021-07-07", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "issn-l": null, "volume": "21", "issue": "1", "pages": "656"}, "abstract": "Coronavirus Disease 2019 (Covid-19) is expanding worldwide. The characteristics of this infection in patients varies from country to country. To move forward, clinical data on infected patients are needed. Here, we report a comparison between fatalities and recovery of patients with severe Covid-19, based on demographic and clinical characteristics.\r\n\r\nBetween 5 March and 12 May 2020 in Mashhad, Iran, 1278 of 4000 suspected Covid-19 patients were confirmed positive by real-time reverse-transcriptase-polymerase-chain-reaction assay of upper respiratory specimens. We compared the demographic, exposure history and clinical symptoms of 925 survivors and 353 fatal cases with confirmed disease.\r\n\r\nMean (SD) age for all confirmed patients was 56.9 (18.7) years, 67.1 (15.9) years in fatal cases and 53.0 (18.3) years in survivors. Multivariate logistic regression analysis showed that the outcome of patients was associated with age (odds ratio = 1.049, P = 0.0001, 95% CI = 1.040-1.057). Despite a high burden of Covid-19 infections in the 30-39 and 40-49 year age groups, most of these (89.6 and 87.2%, respectively) recovered. The median (IQR) duration of hospitalization was 9.0 (6.0-14.0) days. The most prevalent co-morbidities were cardiovascular disorders (21%) and diabetes (16.3%). Dyspnoea (72.7%), cough (68.1%) and fever (63.8%) were the most frequent clinical symptoms. Healthcare workers, of whom two (3%) died, comprised 5.2% of infected cases. Combination antiviral and antibiotic therapy was used in 43.0% of cases.\r\n\r\nThe characteristics of severe Covid-19 varied substantially between fatal cases and survivors, with diabetes and cardiovascular disorders the most prevalent co-morbidities. In contrast to other studies, there were a higher number of fatalities in younger patients in our setting.", "doi": "10.1186/s12879-021-06363-6", "pmid": "34233638", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12879-021-06363-6"}, {"db": "pmc", "key": "PMC8261035"}], "notes": [], "created": "2021-08-06T08:33:39.532Z", "modified": "2021-11-18T08:22:21.313Z"}, {"entity": "publication", "iuid": "5f14b7f1e44e4454be7287fb1a635e96", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f14b7f1e44e4454be7287fb1a635e96.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f14b7f1e44e4454be7287fb1a635e96"}}, "title": "An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism.", "authors": [{"family": "Razzaq", "given": "Misbah", "initials": "M"}, {"family": "Iglesias", "given": "Maria Jesus", "initials": "MJ"}, {"family": "Ibrahim-Kosta", "given": "Manal", "initials": "M"}, {"family": "Goumidi", "given": "Louisa", "initials": "L"}, {"family": "Soukarieh", "given": "Omar", "initials": "O"}, {"family": "Proust", "given": "Carole", "initials": "C"}, {"family": "Roux", "given": "Maguelonne", "initials": "M"}, {"family": "Suchon", "given": "Pierre", "initials": "P"}, {"family": "Boland", "given": "Anne", "initials": "A"}, {"family": "Daiain", "given": "Delphine", "initials": "D"}, {"family": "Olaso", "given": "Robert", "initials": "R"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Thalin", "given": "Charlotte", "initials": "C"}, {"family": "Butler", "given": "Lynn", "initials": "L"}, {"family": "Deleuze", "given": "Jean-Fran\u00e7ois", "initials": "J"}, {"family": "Odeberg", "given": "Jacob", "initials": "J"}, {"family": "Morange", "given": "Pierre-Emmanuel", "initials": "P"}, {"family": "Tr\u00e9gou\u00ebt", "given": "David-Alexandre", "initials": "D"}], "type": "journal article", "published": "2021-07-07", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "14015"}, "abstract": "Venous thromboembolism is the third common cardiovascular disease and is composed of two entities, deep vein thrombosis (DVT) and its potential fatal form, pulmonary embolism (PE). While PE is observed in ~ 40% of patients with documented DVT, there is limited biomarkers that can help identifying patients at high PE risk. To fill this need, we implemented a two hidden-layers artificial neural networks (ANN) on 376 antibodies and 19 biological traits measured in the plasma of 1388 DVT patients, with or without PE, of the MARTHA study. We used the LIME algorithm to obtain a linear approximate of the resulting ANN prediction model. As MARTHA patients were typed for genotyping DNA arrays, a genome wide association study (GWAS) was conducted on the LIME estimate. Detected single nucleotide polymorphisms (SNPs) were tested for association with PE risk in MARTHA. Main findings were replicated in the EOVT study composed of 143 PE patients and 196 DVT only patients. The derived ANN model for PE achieved an accuracy of 0.89 and 0.79 in our training and testing sets, respectively. A GWAS on the LIME approximate identified a strong statistical association peak (rs1424597: p = 5.3 \u00d7 10-7) at the PLXNA4 locus. Homozygote carriers for the rs1424597-A allele were then more frequently observed in PE than in DVT patients from the MARTHA (2% vs. 0.4%, p = 0.005) and the EOVT (3% vs. 0%, p = 0.013) studies. In a sample of 112 COVID-19 patients known to have endotheliopathy leading to acute lung injury and an increased risk of PE, decreased PLXNA4 levels were associated (p = 0.025) with worsened respiratory function. Using an original integrated proteomics and genetics strategy, we identified PLXNA4 as a new susceptibility gene for PE whose exact role now needs to be further elucidated.", "doi": "10.1038/s41598-021-93390-7", "pmid": "34234248", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-93390-7"}, {"db": "pmc", "key": "PMC8263618"}, {"db": "URL", "key": "https://zenodo.org/record/4280776#.YCEVVeoo-vc.", "description": "https://zenodo.org/record/4280776#.YCEVVeoo-vc."}], "notes": [], "created": "2021-08-06T08:25:57.051Z", "modified": "2022-02-14T17:54:22.941Z"}, {"entity": "publication", "iuid": "c6e34c3c36b54441ad20f3ed4f9ffd0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c6e34c3c36b54441ad20f3ed4f9ffd0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c6e34c3c36b54441ad20f3ed4f9ffd0e"}}, "title": "Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis.", "authors": [{"family": "Goubet", "given": "Anne-Ga\u00eblle", "initials": "AG", "orcid": "0000-0003-3431-3067", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/003b572826744aa4a622638867e8473b.json"}}, {"family": "Dubuisson", "given": "Agathe", "initials": "A", "orcid": "0000-0002-7526-0769", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb31612735e14dcda96cda1a050505af.json"}}, {"family": "Geraud", "given": "Arthur", "initials": "A"}, {"family": "Danlos", "given": "Fran\u00e7ois-Xavier", "initials": "FX"}, {"family": "Terrisse", "given": "Safae", "initials": "S"}, {"family": "Silva", "given": "Carolina Alves Costa", "initials": "CAC"}, {"family": "Drubay", "given": "Damien", "initials": "D"}, {"family": "Touri", "given": "Lea", "initials": "L"}, {"family": "Picard", "given": "Marion", "initials": "M"}, {"family": "Mazzenga", "given": "Marine", "initials": "M"}, {"family": "Silvin", "given": "Aymeric", "initials": "A"}, {"family": "Dunsmore", "given": "Garett", "initials": "G"}, {"family": "Haddad", "given": "Yacine", "initials": "Y"}, {"family": "Pizzato", "given": "Eugenie", "initials": "E"}, {"family": "Ly", "given": "Pierre", "initials": "P"}, {"family": "Flament", "given": "Caroline", "initials": "C"}, {"family": "Melenotte", "given": "Cl\u00e9a", "initials": "C"}, {"family": "Solary", "given": "Eric", "initials": "E", "orcid": "0000-0002-8629-1341", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5c0dc972ff945478e729c6ec852a31d.json"}}, {"family": "Fontenay", "given": "Michaela", "initials": "M"}, {"family": "Garcia", "given": "Gabriel", "initials": "G"}, {"family": "Balleyguier", "given": "Corinne", "initials": "C"}, {"family": "Lassau", "given": "Nathalie", "initials": "N"}, {"family": "Maeurer", "given": "Markus", "initials": "M"}, {"family": "Grajeda-Iglesias", "given": "Claudia", "initials": "C"}, {"family": "Nirmalathasan", "given": "Nitharsshini", "initials": "N"}, {"family": "Aprahamian", "given": "Fanny", "initials": "F"}, {"family": "Durand", "given": "Sylv\u00e8re", "initials": "S"}, {"family": "Kepp", "given": "Oliver", "initials": "O", "orcid": "0000-0002-6081-9558", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9c6472b9f7440289a5d69e4c3ce4242.json"}}, {"family": "Ferrere", "given": "Gladys", "initials": "G"}, {"family": "Thelemaque", "given": "Cassandra", "initials": "C"}, {"family": "Lahmar", "given": "Imran", "initials": "I"}, {"family": "Fahrner", "given": "Jean-Eudes", "initials": "JE", "orcid": "0000-0001-6581-8418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/377e7032a04e48889630c1b3b1752bc7.json"}}, {"family": "Meziani", "given": "Lydia", "initials": "L"}, {"family": "Ahmed-Belkacem", "given": "Abdelhakim", "initials": "A", "orcid": "0000-0001-6489-5091", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6210518b0774ba49795f0f323b95dcf.json"}}, {"family": "Sa\u00efdani", "given": "Nadia", "initials": "N"}, {"family": "La Scola", "given": "Bernard", "initials": "B"}, {"family": "Raoult", "given": "Didier", "initials": "D"}, {"family": "Gentile", "given": "St\u00e9phanie", "initials": "S"}, {"family": "Cortaredona", "given": "S\u00e9bastien", "initials": "S"}, {"family": "Ippolito", "given": "Giuseppe", "initials": "G", "orcid": "0000-0002-1076-2979", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e11491db391a466aa783fbebfb315b4e.json"}}, {"family": "Lelouvier", "given": "Benjamin", "initials": "B"}, {"family": "Roulet", "given": "Alain", "initials": "A"}, {"family": "Andre", "given": "Fabrice", "initials": "F"}, {"family": "Barlesi", "given": "Fabrice", "initials": "F"}, {"family": "Soria", "given": "Jean-Charles", "initials": "JC"}, {"family": "Pradon", "given": "Caroline", "initials": "C"}, {"family": "Gallois", "given": "Emmanuelle", "initials": "E"}, {"family": "Pommeret", "given": "Fanny", "initials": "F"}, {"family": "Colomba", "given": "Emeline", "initials": "E"}, {"family": "Ginhoux", "given": "Florent", "initials": "F", "orcid": "0000-0002-2857-7755", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/71216e36b29a430b9740ad40de938a22.json"}}, {"family": "Kazandjian", "given": "Suzanne", "initials": "S"}, {"family": "Elkrief", "given": "Arielle", "initials": "A"}, {"family": "Routy", "given": "Bertrand", "initials": "B"}, {"family": "Miyara", "given": "Makoto", "initials": "M"}, {"family": "Gorochov", "given": "Guy", "initials": "G"}, {"family": "Deutsch", "given": "Eric", "initials": "E", "orcid": "0000-0002-8223-3697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09cfd1799b094229bb96399296b44812.json"}}, {"family": "Albiges", "given": "Laurence", "initials": "L"}, {"family": "Stoclin", "given": "Annabelle", "initials": "A"}, {"family": "Gachot", "given": "Bertrand", "initials": "B"}, {"family": "Florin", "given": "Anne", "initials": "A"}, {"family": "Merad", "given": "Mansouria", "initials": "M"}, {"family": "Scotte", "given": "Florian", "initials": "F"}, {"family": "Assaad", "given": "Souad", "initials": "S"}, {"family": "Kroemer", "given": "Guido", "initials": "G", "orcid": "0000-0002-9334-4405", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d17de2122d0429eaa48a733bf2ad28e.json"}}, {"family": "Blay", "given": "Jean-Yves", "initials": "JY", "orcid": "0000-0001-7190-120X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0021df4cfc98475db66480f47f20f6ed.json"}}, {"family": "Marabelle", "given": "Aur\u00e9lien", "initials": "A", "orcid": "0000-0002-5816-3019", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dfe92c547ebd4c5a9915777c1b1580b5.json"}}, {"family": "Griscelli", "given": "Frank", "initials": "F"}, {"family": "Zitvogel", "given": "Laurence", "initials": "L", "orcid": "0000-0003-1596-0998", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b10947c1a2b4884b3f502625a28c5e0.json"}}, {"family": "Derosa", "given": "Lisa", "initials": "L"}], "type": "journal article", "published": "2021-07-06", "journal": {"title": "Cell Death Differ", "issn": "1476-5403", "issn-l": null}, "abstract": "Patients with cancer are at higher risk of severe coronavirus infectious disease 2019 (COVID-19), but the mechanisms underlying virus-host interactions during cancer therapies remain elusive. When comparing nasopharyngeal swabs from cancer and noncancer patients for RT-qPCR cycle thresholds measuring acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in 1063 patients (58% with cancer), we found that malignant disease favors the magnitude and duration of viral RNA shedding concomitant with prolonged serum elevations of type 1 IFN that anticorrelated with anti-RBD IgG antibodies. Cancer patients with a prolonged SARS-CoV-2 RNA detection exhibited the typical immunopathology of severe COVID-19 at the early phase of infection including circulation of immature neutrophils, depletion of nonconventional monocytes, and a general lymphopenia that, however, was accompanied by a rise in plasmablasts, activated follicular T-helper cells, and non-naive Granzyme B+FasL+, EomeshighTCF-1high, PD-1+CD8+ Tc1 cells. Virus-induced lymphopenia worsened cancer-associated lymphocyte loss, and low lymphocyte counts correlated with chronic SARS-CoV-2 RNA shedding, COVID-19 severity, and a higher risk of cancer-related death in the first and second surge of the pandemic. Lymphocyte loss correlated with significant changes in metabolites from the polyamine and biliary salt pathways as well as increased blood DNA from Enterobacteriaceae and Micrococcaceae gut family members in long-term viral carriers. We surmise that cancer therapies may exacerbate the paradoxical association between lymphopenia and COVID-19-related immunopathology, and that the prevention of COVID-19-induced lymphocyte loss may reduce cancer-associated death.", "doi": "10.1038/s41418-021-00817-9", "pmid": "34230615", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41418-021-00817-9"}, {"db": "pmc", "key": "PMC8259103"}], "notes": [], "created": "2021-08-06T08:35:17.454Z", "modified": "2021-08-06T08:35:17.732Z"}, {"entity": "publication", "iuid": "335924efcd6347e3b429b4cd0e13559e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/335924efcd6347e3b429b4cd0e13559e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/335924efcd6347e3b429b4cd0e13559e"}}, "title": "Mendelian randomization analysis provides causality of smoking on the expression of ACE2, a putative SARS-CoV-2 receptor.", "authors": [{"family": "Liu", "given": "Hui", "initials": "H", "orcid": "0000-0002-5531-3640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/834c6d4bd0fe438890f5b0cae725692e.json"}}, {"family": "Xin", "given": "Junyi", "initials": "J", "orcid": "0000-0001-6677-3936", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05e1800a0c744052a2302ae98907dc4b.json"}}, {"family": "Cai", "given": "Sheng", "initials": "S"}, {"family": "Jiang", "given": "Xia", "initials": "X", "orcid": "0000-0001-5878-8986", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d87c42578c2b4d34bdcd126c84bdef52.json"}}], "type": "journal article", "published": "2021-07-06", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "10", "issn-l": null}, "abstract": "To understand a causal role of modifiable lifestyle factors in angiotensin-converting enzyme 2 (ACE2) expression (a putative severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] receptor) across 44 human tissues/organs, and in coronavirus disease 2019 (COVID-19) susceptibility and severity, we conducted a phenome-wide two-sample Mendelian randomization (MR) study.\n\nMore than 500 genetic variants were used as instrumental variables to predict smoking and alcohol consumption. Inverse-variance weighted approach was adopted as the primary method to estimate a causal association, while MR-Egger regression, weighted median, and MR pleiotropy residual sum and outlier (MR-PRESSO) were performed to identify potential horizontal pleiotropy.\n\nWe found that genetically predicted smoking intensity significantly increased ACE2 expression in thyroid (\u03b2=1.468, p=1.8\u00d710-8), and increased ACE2 expression in adipose, brain, colon, and liver with nominal significance. Additionally, genetically predicted smoking initiation significantly increased the risk of COVID-19 onset (odds ratio=1.14, p=8.7\u00d710-5). No statistically significant result was observed for alcohol consumption.\n\nOur work demonstrates an important role of smoking, measured by both status and intensity, in the susceptibility to COVID-19.\n\nXJ is supported by research grants from the Swedish Research Council (VR-2018-02247) and Swedish Research Council for Health, Working Life and Welfare (FORTE-2020-00884).", "doi": "10.7554/eLife.64188", "pmid": "34227468", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "64188"}, {"db": "pmc", "key": "PMC8282334"}], "notes": [], "created": "2021-08-06T08:40:08.264Z", "modified": "2021-08-06T08:40:19.359Z"}, {"entity": "publication", "iuid": "4ee333715e0a46dd95a2041abd266fbd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ee333715e0a46dd95a2041abd266fbd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ee333715e0a46dd95a2041abd266fbd"}}, "title": "Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis.", "authors": [{"family": "WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group", "given": "", "initials": ""}, {"family": "Shankar-Hari", "given": "Manu", "initials": "M"}, {"family": "Vale", "given": "Claire L", "initials": "CL"}, {"family": "Godolphin", "given": "Peter J", "initials": "PJ"}, {"family": "Fisher", "given": "David", "initials": "D"}, {"family": "Higgins", "given": "Julian P T", "initials": "JPT"}, {"family": "Spiga", "given": "Francesca", "initials": "F"}, {"family": "Savovic", "given": "Jelena", "initials": "J"}, {"family": "Tierney", "given": "Jayne", "initials": "J"}, {"family": "Baron", "given": "Gabriel", "initials": "G"}, {"family": "Benbenishty", "given": "Julie S", "initials": "JS"}, {"family": "Berry", "given": "Lindsay R", "initials": "LR"}, {"family": "Broman", "given": "Niklas", "initials": "N"}, {"family": "Cavalcanti", "given": "Alexandre Biasi", "initials": "AB"}, {"family": "Colman", "given": "Roos", "initials": "R"}, {"family": "De Buyser", "given": "Stefanie L", "initials": "SL"}, {"family": "Derde", "given": "Lennie P G", "initials": "LPG"}, {"family": "Domingo", "given": "Pere", "initials": "P"}, {"family": "Omar", "given": "Sharifah Faridah", "initials": "SF"}, {"family": "Fernandez-Cruz", "given": "Ana", "initials": "A"}, {"family": "Feuth", "given": "Thijs", "initials": "T"}, {"family": "Garcia", "given": "Felipe", "initials": "F"}, {"family": "Garcia-Vicuna", "given": "Rosario", "initials": "R"}, {"family": "Gonzalez-Alvaro", "given": "Isidoro", "initials": "I"}, {"family": "Gordon", "given": "Anthony C", "initials": "AC"}, {"family": "Haynes", "given": "Richard", "initials": "R"}, {"family": "Hermine", "given": "Olivier", "initials": "O"}, {"family": "Horby", "given": "Peter W", "initials": "PW"}, {"family": "Horick", "given": "Nora K", "initials": "NK"}, {"family": "Kumar", "given": "Kuldeep", "initials": "K"}, {"family": "Lambrecht", "given": "Bart N", "initials": "BN"}, {"family": "Landray", "given": "Martin J", "initials": "MJ"}, {"family": "Leal", "given": "Lorna", "initials": "L"}, {"family": "Lederer", "given": "David J", "initials": "DJ"}, {"family": "Lorenzi", "given": "Elizabeth", "initials": "E"}, {"family": "Mariette", "given": "Xavier", "initials": "X"}, {"family": "Merchante", "given": "Nicolas", "initials": "N"}, {"family": "Misnan", "given": "Nor Arisah", "initials": "NA"}, {"family": "Mohan", "given": "Shalini V", "initials": "SV"}, {"family": "Nivens", "given": "Michael C", "initials": "MC"}, {"family": "Oksi", "given": "Jarmo", "initials": "J"}, {"family": "Perez-Molina", "given": "Jose A", "initials": "JA"}, {"family": "Pizov", "given": "Reuven", "initials": "R"}, {"family": "Porcher", "given": "Raphael", "initials": "R"}, {"family": "Postma", "given": "Simone", "initials": "S"}, {"family": "Rajasuriar", "given": "Reena", "initials": "R"}, {"family": "Ramanan", "given": "Athimalaipet V", "initials": "AV"}, {"family": "Ravaud", "given": "Philippe", "initials": "P"}, {"family": "Reid", "given": "Pankti D", "initials": "PD"}, {"family": "Rutgers", "given": "Abraham", "initials": "A"}, {"family": "Sancho-Lopez", "given": "Aranzazu", "initials": "A"}, {"family": "Seto", "given": "Todd B", "initials": "TB"}, {"family": "Sivapalasingam", "given": "Sumathi", "initials": "S"}, {"family": "Soin", "given": "Arvinder Singh", "initials": "AS"}, {"family": "Staplin", "given": "Natalie", "initials": "N"}, {"family": "Stone", "given": "John H", "initials": "JH"}, {"family": "Strohbehn", "given": "Garth W", "initials": "GW"}, {"family": "Sunden-Cullberg", "given": "Jonas", "initials": "J"}, {"family": "Torre-Cisneros", "given": "Julian", "initials": "J"}, {"family": "Tsai", "given": "Larry W", "initials": "LW"}, {"family": "van Hoogstraten", "given": "Hubert", "initials": "H"}, {"family": "van Meerten", "given": "Tom", "initials": "T"}, {"family": "Veiga", "given": "Viviane Cordeiro", "initials": "VC"}, {"family": "Westerweel", "given": "Peter E", "initials": "PE"}, {"family": "Murthy", "given": "Srinivas", "initials": "S"}, {"family": "Diaz", "given": "Janet V", "initials": "JV"}, {"family": "Marshall", "given": "John C", "initials": "JC"}, {"family": "Sterne", "given": "Jonathan A C", "initials": "JAC"}], "type": "journal article", "published": "2021-07-06", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484"}, "abstract": "Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized for COVID-19 have variously reported benefit, no effect, and harm.\n\nTo estimate the association between administration of IL-6 antagonists compared with usual care or placebo and 28-day all-cause mortality and other outcomes.\n\nTrials were identified through systematic searches of electronic databases between October 2020 and January 2021. Searches were not restricted by trial status or language. Additional trials were identified through contact with experts.\n\nEligible trials randomly assigned patients hospitalized for COVID-19 to a group in whom IL-6 antagonists were administered and to a group in whom neither IL-6 antagonists nor any other immunomodulators except corticosteroids were administered. Among 72 potentially eligible trials, 27 (37.5%) met study selection criteria.\n\nIn this prospective meta-analysis, risk of bias was assessed using the Cochrane Risk of Bias Assessment Tool. Inconsistency among trial results was assessed using the I2 statistic. The primary analysis was an inverse variance-weighted fixed-effects meta-analysis of odds ratios (ORs) for 28-day all-cause mortality.\n\nThe primary outcome measure was all-cause mortality at 28 days after randomization. There were 9 secondary outcomes including progression to invasive mechanical ventilation or death and risk of secondary infection by 28 days.\n\nA total of 10 930 patients (median age, 61 years [range of medians, 52-68 years]; 3560 [33%] were women) participating in 27 trials were included. By 28 days, there were 1407 deaths among 6449 patients randomized to IL-6 antagonists and 1158 deaths among 4481 patients randomized to usual care or placebo (summary OR, 0.86 [95% CI, 0.79-0.95]; P = .003 based on a fixed-effects meta-analysis). This corresponds to an absolute mortality risk of 22% for IL-6 antagonists compared with an assumed mortality risk of 25% for usual care or placebo. The corresponding summary ORs were 0.83 (95% CI, 0.74-0.92; P < .001) for tocilizumab and 1.08 (95% CI, 0.86-1.36; P = .52) for sarilumab. The summary ORs for the association with mortality compared with usual care or placebo in those receiving corticosteroids were 0.77 (95% CI, 0.68-0.87) for tocilizumab and 0.92 (95% CI, 0.61-1.38) for sarilumab. The ORs for the association with progression to invasive mechanical ventilation or death, compared with usual care or placebo, were 0.77 (95% CI, 0.70-0.85) for all IL-6 antagonists, 0.74 (95% CI, 0.66-0.82) for tocilizumab, and 1.00 (95% CI, 0.74-1.34) for sarilumab. Secondary infections by 28 days occurred in 21.9% of patients treated with IL-6 antagonists vs 17.6% of patients treated with usual care or placebo (OR accounting for trial sample sizes, 0.99; 95% CI, 0.85-1.16).\n\nIn this prospective meta-analysis of clinical trials of patients hospitalized for COVID-19, administration of IL-6 antagonists, compared with usual care or placebo, was associated with lower 28-day all-cause mortality.\n\nPROSPERO Identifier: CRD42021230155.", "doi": "10.1001/jama.2021.11330", "pmid": "34228774", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "2781880"}, {"db": "pmc", "key": "PMC8261689"}], "notes": [], "created": "2021-08-06T08:36:54.854Z", "modified": "2021-08-06T08:37:13.476Z"}, {"entity": "publication", "iuid": "a6dcc2a2bf4a4852b94c061b5e660397", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6dcc2a2bf4a4852b94c061b5e660397.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6dcc2a2bf4a4852b94c061b5e660397"}}, "title": "SARS-CoV-2-specific humoral and cellular immunity persists through 9 months irrespective of COVID-19 severity at hospitalisation.", "authors": [{"family": "Sandberg", "given": "John Tyler", "initials": "JT", "orcid": "0000-0001-6747-6933", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dfe4b6f5f2f24420bd78d7ae9b71e2d4.json"}}, {"family": "Varnait\u0117", "given": "Renata", "initials": "R", "orcid": "0000-0001-9391-9291", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05a03781d1c84aad85895298c193c575.json"}}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f2dc27d02294a15a6f691be6aab641f.json"}}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Muvva", "given": "Jagadeeswara R", "initials": "JR"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Garc\u00eda", "given": "Marina", "initials": "M", "orcid": "0000-0002-9130-3933", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5b109d7a54e4c05a48e0f21c4432be6.json"}}, {"family": "Dzidic", "given": "Majda", "initials": "M"}, {"family": "Folkesson", "given": "Elin", "initials": "E"}, {"family": "Skagerberg", "given": "Magdalena", "initials": "M"}, {"family": "Ahl\u00e9n", "given": "Gustaf", "initials": "G"}, {"family": "Frelin", "given": "Lars", "initials": "L"}, {"family": "S\u00e4llberg", "given": "Matti", "initials": "M"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Blom", "given": "Kim", "initials": "K", "orcid": "0000-0002-5286-3735", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/636cd4b9609b43d9b6ddbb10a7e2553a.json"}}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Karolinska COVID\u201019 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-07-05", "journal": {"title": "Clin Transl Immunol", "issn": "2050-0068", "issn-l": null, "volume": "10", "issue": "7", "pages": "e1306"}, "abstract": "Humoral and cellular immunity to SARS-CoV-2 following COVID-19 will likely contribute to protection from reinfection or severe disease. It is therefore important to characterise the initiation and persistence of adaptive immunity to SARS-CoV-2 amidst the ongoing pandemic.\n\nHere, we conducted a longitudinal study on hospitalised moderate and severe COVID-19 patients from the acute phase of disease into convalescence at 5 and 9 months post-symptom onset. Utilising flow cytometry, serological assays as well as B cell and T cell FluoroSpot assays, we assessed the magnitude and specificity of humoral and cellular immune responses during and after human SARS-CoV-2 infection.\n\nDuring acute COVID-19, we observed an increase in germinal centre activity, a substantial expansion of antibody-secreting cells and the generation of SARS-CoV-2-neutralising antibodies. Despite gradually decreasing antibody levels, we show persistent, neutralising antibody titres as well as robust specific memory B cell responses and polyfunctional T cell responses at 5 and 9 months after symptom onset in both moderate and severe COVID-19 patients.\n\nOur findings describe the initiation and, importantly, persistence of cellular and humoral SARS-CoV-2-specific immunological memory in hospitalised COVID-19 patients long after recovery, likely contributing towards protection against reinfection.", "doi": "10.1002/cti2.1306", "pmid": "34257967", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC8256672"}, {"db": "pii", "key": "CTI21306"}], "notes": [], "created": "2021-08-06T07:28:49.240Z", "modified": "2023-06-19T14:32:39.642Z"}, {"entity": "publication", "iuid": "a8a1f08519534f2b9ad1e1c26c3c0bd6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8a1f08519534f2b9ad1e1c26c3c0bd6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8a1f08519534f2b9ad1e1c26c3c0bd6"}}, "title": "Randomised, controlled, open label, multicentre clinical trial to explore safety and efficacy of hyperbaric oxygen for preventing ICU admission, morbidity and mortality in adult patients with COVID-19.", "authors": [{"family": "Kjellberg", "given": "Anders", "initials": "A", "orcid": "0000-0002-4819-1024", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81941232265d46679c08c40c068e91c4.json"}}, {"family": "Douglas", "given": "Johan", "initials": "J"}, {"family": "Pawlik", "given": "Michael T", "initials": "MT"}, {"family": "Kraus", "given": "Michael", "initials": "M"}, {"family": "Oscarsson", "given": "Nicklas", "initials": "N", "orcid": "0000-0002-0460-1829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1cbe3fa1d184960b75b8c4d9f3815a5.json"}}, {"family": "Zheng", "given": "Xiaowei", "initials": "X", "orcid": "0000-0002-2648-1119", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11b4ff5b9cea4b20afef48998931a75d.json"}}, {"family": "Bergman", "given": "Peter", "initials": "P", "orcid": "0000-0003-3306-3713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15b7290255814a7b9a1a97c3cdb2fc26.json"}}, {"family": "Fr\u00e5nberg", "given": "Oskar", "initials": "O", "orcid": "0000-0001-7051-3256", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7cdc60d7c4cb4bd7973fb282761e6191.json"}}, {"family": "Kowalski", "given": "Jan H", "initials": "JH"}, {"family": "Nyren", "given": "Sven Paul", "initials": "SP"}, {"family": "Silvanius", "given": "M\u00e5rten", "initials": "M", "orcid": "0000-0002-4629-6324", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45f5315fd0084d31a810787a8768cfc2.json"}}, {"family": "Skold", "given": "Magnus", "initials": "M"}, {"family": "Catrina", "given": "Sergiu-Bogdan", "initials": "SB", "orcid": "0000-0002-6914-3902", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/855bdd67b10940528effc10f51b92e17.json"}}, {"family": "Rodriguez-Wallberg", "given": "Kenny A", "initials": "KA", "orcid": "0000-0003-4378-6181", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d45aa8a66f64858b4f9be050046e8a2.json"}}, {"family": "Lindholm", "given": "Peter", "initials": "P", "orcid": "0000-0002-0840-9244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e98ca6dca1542a3acbd5a0516f0254d.json"}}], "type": "journal article", "published": "2021-07-05", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "7", "pages": "e046738", "issn-l": "2044-6055"}, "abstract": "COVID-19 may cause severe pneumonitis and trigger a massive inflammatory response that requires ventilatory support. The intensive care unit (ICU)-mortality has been reported to be as high as 62%. Dexamethasone is the only of all anti-inflammatory drugs that have been tested to date that has shown a positive effect on mortality. We aim to explore if treatment with hyperbaric oxygen (HBO) is safe and effective for patients with severe COVID-19. Our hypothesis is that HBO can prevent ICU admission, morbidity and mortality by attenuating the inflammatory response. The primary objective is to evaluate if HBO reduces the number of ICU admissions compared with best practice treatment for COVID-19, main secondary objectives are to evaluate if HBO reduces the load on ICU resources, morbidity and mortality and to evaluate if HBO mitigates the inflammatory reaction in COVID-19.\n\nA randomised, controlled, phase II, open label, multicentre trial. 200 subjects with severe COVID-19 and at least two risk factors for mortality will be included. Baseline clinical data and blood samples will be collected before randomisation and repeated daily for 7 days, at days 14 and 30. Subjects will be randomised with a computer-based system to HBO, maximum five times during the first 7 days plus best practice treatment or only best practice treatment. The primary endpoint, ICU admission, is defined by criteria for selection for ICU. We will evaluate if HBO mitigates the inflammatory reaction in COVID-19 using molecular analyses. All parameters are recorded in an electronic case report form. An independent Data Safety Monitoring Board will review the safety parameters.\n\nThe trial is approved by The National Institutional Review Board in Sweden (2020-01705) and the Swedish Medical Product Agency (5.1-2020-36673). Positive, negative and any inconclusive results will be published in peer-reviewed scientific journals with open access.\n\nNCT04327505. EudraCT number: 2020-001349-37.", "doi": "10.1136/bmjopen-2020-046738", "pmid": "34226219", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-046738"}, {"db": "pmc", "key": "PMC8260306"}, {"db": "ClinicalTrials.gov", "key": "NCT04327505"}, {"db": "EudraCT", "key": "2020-001349-37"}], "notes": [], "created": "2021-08-06T08:44:46.219Z", "modified": "2021-08-06T08:44:46.421Z"}, {"entity": "publication", "iuid": "bb3af7105efd4b57a5877b70928dfa57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb3af7105efd4b57a5877b70928dfa57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb3af7105efd4b57a5877b70928dfa57"}}, "title": "Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1.", "authors": [{"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Orlova", "given": "Elizaveta", "initials": "E"}, {"family": "Sozaeva", "given": "Leila", "initials": "L"}, {"family": "L\u00e9vy", "given": "Romain", "initials": "R"}, {"family": "James", "given": "Alyssa", "initials": "A"}, {"family": "Schmitt", "given": "Monica M", "initials": "MM"}, {"family": "Ochoa", "given": "Sebastian", "initials": "S"}, {"family": "Kareva", "given": "Maria", "initials": "M"}, {"family": "Rodina", "given": "Yulia", "initials": "Y"}, {"family": "Gervais", "given": "Adrian", "initials": "A"}, {"family": "Le Voyer", "given": "Tom", "initials": "T"}, {"family": "Rosain", "given": "J\u00e9r\u00e9mie", "initials": "J"}, {"family": "Philippot", "given": "Quentin", "initials": "Q"}, {"family": "Neehus", "given": "Anna-Lena", "initials": "AL"}, {"family": "Shaw", "given": "Elana", "initials": "E"}, {"family": "Migaud", "given": "M\u00e9lanie", "initials": "M"}, {"family": "Bizien", "given": "Lucy", "initials": "L"}, {"family": "Ekwall", "given": "Olov", "initials": "O"}, {"family": "Berg", "given": "Stefan", "initials": "S"}, {"family": "Beccuti", "given": "Guglielmo", "initials": "G"}, {"family": "Ghizzoni", "given": "Lucia", "initials": "L"}, {"family": "Thiriez", "given": "G\u00e9rard", "initials": "G"}, {"family": "Pavot", "given": "Arthur", "initials": "A"}, {"family": "Goujard", "given": "C\u00e9cile", "initials": "C"}, {"family": "Fr\u00e9mond", "given": "Marie-Louise", "initials": "ML"}, {"family": "Carter", "given": "Edwin", "initials": "E"}, {"family": "Rothenbuhler", "given": "Anya", "initials": "A"}, {"family": "Linglart", "given": "Agn\u00e8s", "initials": "A"}, {"family": "Mignot", "given": "Brigite", "initials": "B"}, {"family": "Comte", "given": "Aur\u00e9lie", "initials": "A"}, {"family": "Cheikh", "given": "Nathalie", "initials": "N"}, {"family": "Hermine", "given": "Olivier", "initials": "O"}, {"family": "Breivik", "given": "Lars", "initials": "L"}, {"family": "Husebye", "given": "Eystein S", "initials": "ES"}, {"family": "Humbert", "given": "S\u00e9bastien", "initials": "S"}, {"family": "Rohrlich", "given": "Pierre", "initials": "P"}, {"family": "Coaquette", "given": "Alain", "initials": "A"}, {"family": "Vuoto", "given": "Fanny", "initials": "F"}, {"family": "Faure", "given": "Karine", "initials": "K"}, {"family": "Mahlaoui", "given": "Nizar", "initials": "N"}, {"family": "Kotnik", "given": "Primo\u017e", "initials": "P"}, {"family": "Battelino", "given": "Tadej", "initials": "T"}, {"family": "Trebu\u0161ak Podkraj\u0161ek", "given": "Katarina", "initials": "K"}, {"family": "Kisand", "given": "Kai", "initials": "K"}, {"family": "Ferr\u00e9", "given": "Elise M N", "initials": "EMN"}, {"family": "DiMaggio", "given": "Thomas", "initials": "T"}, {"family": "Rosen", "given": "Lindsey B", "initials": "LB"}, {"family": "Burbelo", "given": "Peter D", "initials": "PD"}, {"family": "McIntyre", "given": "Martin", "initials": "M"}, {"family": "Kann", "given": "Nelli Y", "initials": "NY"}, {"family": "Shcherbina", "given": "Anna", "initials": "A"}, {"family": "Pavlova", "given": "Maria", "initials": "M"}, {"family": "Kolodkina", "given": "Anna", "initials": "A"}, {"family": "Holland", "given": "Steven M", "initials": "SM"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Crow", "given": "Yanick J", "initials": "YJ"}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD"}, {"family": "Su", "given": "Helen C", "initials": "HC"}, {"family": "Abel", "given": "Laurent", "initials": "L"}, {"family": "Anderson", "given": "Mark S", "initials": "MS"}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E"}, {"family": "Neven", "given": "B\u00e9n\u00e9dicte", "initials": "B"}, {"family": "Puel", "given": "Anne", "initials": "A"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL"}, {"family": "Lionakis", "given": "Michail S", "initials": "MS"}], "type": "journal article", "published": "2021-07-05", "journal": {"title": "J Exp Med", "issn": "1540-9538", "volume": "218", "issue": "7", "issn-l": null}, "abstract": "Patients with biallelic loss-of-function variants of AIRE suffer from autoimmune polyendocrine syndrome type-1 (APS-1) and produce a broad range of autoantibodies (auto-Abs), including circulating auto-Abs neutralizing most type I interferons (IFNs). These auto-Abs were recently reported to account for at least 10% of cases of life-threatening COVID-19 pneumonia in the general population. We report 22 APS-1 patients from 21 kindreds in seven countries, aged between 8 and 48 yr and infected with SARS-CoV-2 since February 2020. The 21 patients tested had auto-Abs neutralizing IFN-\u03b1 subtypes and/or IFN-\u03c9; one had anti-IFN-\u03b2 and another anti-IFN-\u03b5, but none had anti-IFN-\u03ba. Strikingly, 19 patients (86%) were hospitalized for COVID-19 pneumonia, including 15 (68%) admitted to an intensive care unit, 11 (50%) who required mechanical ventilation, and four (18%) who died. Ambulatory disease in three patients (14%) was possibly accounted for by prior or early specific interventions. Preexisting auto-Abs neutralizing type I IFNs in APS-1 patients confer a very high risk of life-threatening COVID-19 pneumonia at any age.", "doi": "10.1084/jem.20210554", "pmid": "33890986", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Proteins": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "212019"}], "notes": [], "created": "2021-04-29T15:37:10.750Z", "modified": "2021-04-29T15:37:10.760Z"}, {"entity": "publication", "iuid": "3dcd82f3a4c5470d8cca7f78ab45bf73", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3dcd82f3a4c5470d8cca7f78ab45bf73.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3dcd82f3a4c5470d8cca7f78ab45bf73"}}, "title": "Fitness, strength and severity of COVID-19: a prospective register study of 1 559 187 Swedish conscripts.", "authors": [{"family": "Af Geijerstam", "given": "Agnes", "initials": "A", "orcid": "0000-0002-0897-6548", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ab4ce35a27d446da006cd3aece117c2.json"}}, {"family": "Mehlig", "given": "Kirsten", "initials": "K"}, {"family": "B\u00f6rjesson", "given": "Mats", "initials": "M"}, {"family": "Robertson", "given": "Josefina", "initials": "J"}, {"family": "Nyberg", "given": "Jenny", "initials": "J", "orcid": "0000-0002-4336-3886", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b78a1fdee10c49c8b1adc25be46e4e81.json"}}, {"family": "Adiels", "given": "Martin", "initials": "M"}, {"family": "Rosengren", "given": "Annika", "initials": "A"}, {"family": "\u00c5berg", "given": "Maria", "initials": "M"}, {"family": "Lissner", "given": "Lauren", "initials": "L"}], "type": "journal article", "published": "2021-07-05", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "7", "pages": "e051316"}, "abstract": "To investigate the possible connection between cardiorespiratory fitness (CRF) and muscle strength in early adulthood and severity of COVID-19 later in life.\r\n\r\nProspective registry-based cohort study.\r\n\r\n1 559 187 Swedish men, undergoing military conscription between 1968 and 2005 at a mean age of 18.3 (SD 0.73) years.\r\n\r\nHospitalisation, intensive care or death due to COVID-19 from March to September 2020, in relation to CRF and muscle strength.\r\n\r\nHigh CRF in late adolescence and early adulthood had a protective association with severe COVID-19 later in life with OR (95% CI) 0.76 (0.67 to 0.85) for hospitalisation (n=2 006), 0.61 (0.48 to 0.78) for intensive care (n=445) and 0.56 (0.37 to 0.85) for mortality (n=149), compared with the lowest category of CRF. The association remains unchanged when controlled for body mass index (BMI), blood pressure, chronic diseases and parental education level at baseline, and incident cardiovascular disease before 2020. Moreover, lower muscle strength in late adolescence showed a linear association with a higher risk of all three outcomes when controlled for BMI and height.\r\n\r\nPhysical fitness at a young age is associated with severity of COVID-19 many years later. This underscores the necessity to increase the general physical fitness of the population to offer protection against future viral pandemics.", "doi": "10.1136/bmjopen-2021-051316", "pmid": "34226237", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-051316"}, {"db": "pmc", "key": "PMC8260308"}], "notes": [], "created": "2021-08-06T08:42:38.882Z", "modified": "2021-11-18T08:21:04.348Z"}, {"entity": "publication", "iuid": "db38442d89774784b668ca7f58909833", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db38442d89774784b668ca7f58909833.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db38442d89774784b668ca7f58909833"}}, "title": "Site-Specific Steric Control of SARS-CoV-2 Spike Glycosylation.", "authors": [{"family": "Allen", "given": "Joel D", "initials": "JD", "orcid": "0000-0003-2547-968X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81deac3f18124364945b49be654210ed.json"}}, {"family": "Chawla", "given": "Himanshi", "initials": "H", "orcid": "0000-0001-9828-6593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/882a202ebc104941984b1a642ed2dbe1.json"}}, {"family": "Samsudin", "given": "Firdaus", "initials": "F"}, {"family": "Zuzic", "given": "Lorena", "initials": "L", "orcid": "0000-0002-7834-612X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18d2dac8ab53482ebd2d5d5ba0b5d658.json"}}, {"family": "Shivgan", "given": "Aishwary Tukaram", "initials": "AT", "orcid": "0000-0002-2032-8738", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aaab454de9af4638b44f42b80121e2cc.json"}}, {"family": "Watanabe", "given": "Yasunori", "initials": "Y", "orcid": "0000-0002-7952-1268", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bcf2603906ff489dae169ea389b7a26a.json"}}, {"family": "He", "given": "Wan-Ting", "initials": "WT"}, {"family": "Callaghan", "given": "Sean", "initials": "S"}, {"family": "Song", "given": "Ge", "initials": "G"}, {"family": "Yong", "given": "Peter", "initials": "P", "orcid": "0000-0002-4899-3270", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ec57ed902be4604a6009335eeac6e92.json"}}, {"family": "Brouwer", "given": "Philip J M", "initials": "PJM"}, {"family": "Song", "given": "Yutong", "initials": "Y", "orcid": "0000-0002-2206-9549", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56c58af22e0d432cb6cfca65fc4feafb.json"}}, {"family": "Cai", "given": "Yongfei", "initials": "Y"}, {"family": "Duyvesteyn", "given": "Helen M E", "initials": "HME"}, {"family": "Malinauskas", "given": "Tomas", "initials": "T", "orcid": "0000-0002-4847-5529", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a331fc8e9eb434aadcc98f434a1e867.json"}}, {"family": "Kint", "given": "Joeri", "initials": "J"}, {"family": "Pino", "given": "Paco", "initials": "P"}, {"family": "Wurm", "given": "Maria J", "initials": "MJ"}, {"family": "Frank", "given": "Martin", "initials": "M", "orcid": "0000-0002-1006-6746", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee6b5d165615455da3cf49fad65598e9.json"}}, {"family": "Chen", "given": "Bing", "initials": "B"}, {"family": "Stuart", "given": "David I", "initials": "DI", "orcid": "0000-0002-3426-4210", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c24b849d3d54c2c9c7b0b68faed3d5a.json"}}, {"family": "Sanders", "given": "Rogier W", "initials": "RW"}, {"family": "Andrabi", "given": "Raiees", "initials": "R"}, {"family": "Burton", "given": "Dennis R", "initials": "DR"}, {"family": "Li", "given": "Sai", "initials": "S", "orcid": "0000-0002-9353-0355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56db840c41a54d52876c2ac1c8e5ec35.json"}}, {"family": "Bond", "given": "Peter J", "initials": "PJ", "orcid": "0000-0003-2900-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5bac218641b4642a498eafe60eafcf5.json"}}, {"family": "Crispin", "given": "Max", "initials": "M", "orcid": "0000-0002-1072-2694", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4341966010144757aa3af354e579c713.json"}}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "Biochemistry", "issn": "1520-4995", "issn-l": null}, "abstract": "A central tenet in the design of vaccines is the display of native-like antigens in the elicitation of protective immunity. The abundance of N-linked glycans across the SARS-CoV-2 spike protein is a potential source of heterogeneity among the many different vaccine candidates under investigation. Here, we investigate the glycosylation of recombinant SARS-CoV-2 spike proteins from five different laboratories and compare them against S protein from infectious virus, cultured in Vero cells. We find patterns that are conserved across all samples, and this can be associated with site-specific stalling of glycan maturation that acts as a highly sensitive reporter of protein structure. Molecular dynamics simulations of a fully glycosylated spike support a model of steric restrictions that shape enzymatic processing of the glycans. These results suggest that recombinant spike-based SARS-CoV-2 immunogen glycosylation reproducibly recapitulates signatures of viral glycosylation.", "doi": "10.1021/acs.biochem.1c00279", "pmid": "34213308", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-07-05T14:59:39.053Z", "modified": "2021-07-05T14:59:39.310Z"}, {"entity": "publication", "iuid": "4272a6d8972e4112944a7ff85e4a5385", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4272a6d8972e4112944a7ff85e4a5385.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4272a6d8972e4112944a7ff85e4a5385"}}, "title": "Perceived changes in capability during the COVID-19 pandemic: A Swedish cross-sectional study from June 2020.", "authors": [{"family": "Meili", "given": "Kaspar Walter", "initials": "KW"}, {"family": "Jonsson", "given": "H\u00e5kan", "initials": "H"}, {"family": "Lindholm", "given": "Lars", "initials": "L"}, {"family": "M\u00e5nsdotter", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": null, "issue": null, "pages": "14034948211023633"}, "abstract": "Measures against COVID-19 potentially impact quality of life in different ways. The capability approach by Amartya Sen with a broad and consistent framework for measuring quality of life is suited to capture the various consequences. We aimed to examine (a) whether individuals experienced change in 10 capability dimensions during the first half of 2020, (b) which dimensions were affected most, and (c) whether changes were unequally distributed in terms of gender, education, income, geography, housing, living situation and place of birth.\r\n\r\nWe assessed self-reported capability change in Sweden in 10 capability dimensions in a cross-sectional online survey among 500 participants on a five-item Likert scale. We analysed the distribution of answers by comparing the balance of positive and negative perceived changes and used mixed effects logistic regression to examine associations with background characteristics of the participants.\r\n\r\nReported perceived negative changes outweighed positive changes, and a higher proportion stated negative perceived changes if they also stated having low capability in the same dimension. In the capabilities of financial situation, political resources and health, the proportions of perceived negative change were highest. Odds for perceived negative change compared to no or positive change were higher for higher incomes, living in medium-sized municipalities, being born outside Europe, living in the south of Sweden, and renting instead of owning housing.\r\n\r\nSelf-reported negative capability change, and associated inequalities related to socioeconomic position, place of birth and regional residence should be of concern for policymakers.", "doi": "10.1177/14034948211023633", "pmid": "34213363", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "URL", "key": "https://snd.gu.se/sv/catalogue/study/2020-206/1/1#dataset", "description": "Dataset: capability change covid-19"}], "notes": [], "created": "2021-07-05T15:00:45.933Z", "modified": "2021-07-14T11:52:21.660Z"}, {"entity": "publication", "iuid": "d5f7250bfeb6416cb1876c988606d4d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5f7250bfeb6416cb1876c988606d4d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5f7250bfeb6416cb1876c988606d4d4"}}, "title": "Mobility restrictions were associated with reductions in COVID-19 incidence early in the pandemic: evidence from a real-time evaluation in 34 countries.", "authors": [{"family": "Oh", "given": "Juhwan", "initials": "J"}, {"family": "Lee", "given": "Hwa-Young", "initials": "HY"}, {"family": "Khuong", "given": "Quynh Long", "initials": "QL"}, {"family": "Markuns", "given": "Jeffrey F", "initials": "JF"}, {"family": "Bullen", "given": "Chris", "initials": "C"}, {"family": "Barrios", "given": "Osvaldo Enrique Artaza", "initials": "OEA"}, {"family": "Hwang", "given": "Seung-Sik", "initials": "SS"}, {"family": "Suh", "given": "Young Sahng", "initials": "YS"}, {"family": "McCool", "given": "Judith", "initials": "J"}, {"family": "Kachur", "given": "S Patrick", "initials": "SP"}, {"family": "Chan", "given": "Chang-Chuan", "initials": "CC"}, {"family": "Kwon", "given": "Soonman", "initials": "S"}, {"family": "Kondo", "given": "Naoki", "initials": "N"}, {"family": "Hoang", "given": "Van Minh", "initials": "VM"}, {"family": "Moon", "given": "J Robin", "initials": "JR"}, {"family": "Rostila", "given": "Mikael", "initials": "M"}, {"family": "Norheim", "given": "Ole F", "initials": "OF"}, {"family": "You", "given": "Myoungsoon", "initials": "M"}, {"family": "Withers", "given": "Mellissa", "initials": "M"}, {"family": "Li", "given": "Mu", "initials": "M"}, {"family": "Lee", "given": "Eun-Jeung", "initials": "EJ"}, {"family": "Benski", "given": "Caroline", "initials": "C"}, {"family": "Park", "given": "Sookyung", "initials": "S"}, {"family": "Nam", "given": "Eun-Woo", "initials": "EW"}, {"family": "Gottschalk", "given": "Katie", "initials": "K"}, {"family": "Kavanagh", "given": "Matthew M", "initials": "MM"}, {"family": "Tran", "given": "Thi Giang Huong", "initials": "TGH"}, {"family": "Lee", "given": "Jong-Koo", "initials": "JK"}, {"family": "Subramanian", "given": "S V", "initials": "SV"}, {"family": "McKee", "given": "Martin", "initials": "M"}, {"family": "Gostin", "given": "Lawrence O", "initials": "LO"}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "13717", "issn-l": "2045-2322"}, "abstract": "Most countries have implemented restrictions on mobility to prevent the spread of Coronavirus disease-19 (COVID-19), entailing considerable societal costs but, at least initially, based on limited evidence of effectiveness. We asked whether mobility restrictions were associated with changes in the occurrence of COVID-19 in 34 OECD countries plus Singapore and Taiwan. Our data sources were the Google Global Mobility Data Source, which reports different types of mobility, and COVID-19 cases retrieved from the dataset curated by Our World in Data. Beginning at each country's 100th case, and incorporating a 14-day lag to account for the delay between exposure and illness, we examined the association between changes in mobility (with January 3 to February 6, 2020 as baseline) and the ratio of the number of newly confirmed cases on a given day to the total number of cases over the past 14 days from the index day (the potentially infective 'pool' in that population), per million population, using LOESS regression and logit regression. In two-thirds of examined countries, reductions of up to 40% in commuting mobility (to workplaces, transit stations, retailers, and recreation) were associated with decreased cases, especially early in the pandemic. Once both mobility and incidence had been brought down, further restrictions provided little additional benefit. These findings point to the importance of acting early and decisively in a pandemic.", "doi": "10.1038/s41598-021-92766-z", "pmid": "34215764", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-92766-z"}], "notes": [], "created": "2021-07-05T15:01:41.748Z", "modified": "2021-07-05T15:01:41.761Z"}, {"entity": "publication", "iuid": "5b593319005f4e1aa7583b3cadcdced8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5b593319005f4e1aa7583b3cadcdced8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5b593319005f4e1aa7583b3cadcdced8"}}, "title": "Increased rate of hospitalisation for COVID-19 among rituximab-treated multiple sclerosis patients: A study of the Swedish multiple sclerosis registry.", "authors": [{"family": "Spelman", "given": "Tim", "initials": "T", "orcid": "0000-0001-9204-3216", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab24deed7243491387cb220c2a0c8606.json"}}, {"family": "Forsberg", "given": "Lars", "initials": "L"}, {"family": "McKay", "given": "Kyla", "initials": "K"}, {"family": "Glaser", "given": "Anna", "initials": "A"}, {"family": "Hillert", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "Mult Scler", "issn": "1477-0970", "pages": "13524585211026272", "issn-l": null}, "abstract": "The primary objective of this study was to analyse the association between multiple sclerosis (MS) disease-modifying therapy (DMT) exposure and hospitalisation in patients infected with COVID-19.\n\nAssociations between MS DMT exposure and COVID-19 hospitalisation were analysed using univariable and multi-variable-clustered propensity score weighted logistic regression, where the models were clustered on the individual patients to control for patients contributing multiple COVID-19 episodes.\n\nAs of 18 January 2021, a total of 476 reported COVID-19 cases had been recorded in MS patients in the Swedish MS registry. Of these, 292 (61.3%) had confirmed COVID-19. The mean value (standard deviation (SD)) age at infection was 44.0 years (11.6). Of the 292 confirmed infections, 68 (23.2%) required hospitalisation. A total of 49 of the 164 confirmed COVID-19 patients on rituximab at baseline (29.9%) required hospitalisation, compared to a rate of 12.7% for all other DMTs combined. Rituximab in confirmed COVID-19 patients was associated with 2.95 times the odds of hospitalisation relative to any other DMT combined (odds ratio = 2.95; 95% confidence interval (CI) = 1.48-5.87).\n\nRituximab treatment, known to increase the risk of severe infections in general, also confers such a risk for MS patients with COVID-19, in comparison with other MS DMTs.", "doi": "10.1177/13524585211026272", "pmid": "34212816", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-07-05T14:58:20.082Z", "modified": "2021-07-05T14:58:20.119Z"}, {"entity": "publication", "iuid": "be233521a08a4dd8a582810f62e9423d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be233521a08a4dd8a582810f62e9423d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be233521a08a4dd8a582810f62e9423d"}}, "title": "High Amounts of SARS-CoV-2 Precede Sickness Among Asymptomatic Health Care Workers.", "authors": [{"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Elfstr\u00f6m", "given": "K Miriam", "initials": "KM"}, {"family": "Blomqvist", "given": "Jonas", "initials": "J"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M"}, {"family": "Eklund", "given": "Carina", "initials": "C"}, {"family": "Boulund", "given": "Fredrik", "initials": "F"}, {"family": "Lagheden", "given": "Camilla", "initials": "C"}, {"family": "Hamsten", "given": "Marica", "initials": "M"}, {"family": "Nordqvist-Kleppe", "given": "Sara", "initials": "S"}, {"family": "Seifert", "given": "Maike", "initials": "M"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Olofsson", "given": "Jennie", "initials": "J"}, {"family": "Andersson", "given": "Eni", "initials": "E"}, {"family": "Falk", "given": "August Jernbom", "initials": "AJ"}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S"}, {"family": "Hultin", "given": "Emilie", "initials": "E"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Pimenoff", "given": "Ville N", "initials": "VN"}, {"family": "Hassan", "given": "Sadaf", "initials": "S"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Mattsson", "given": "Johan", "initials": "J"}, {"family": "Arroyo M\u00fchr", "given": "Laila Sara", "initials": "LS"}, {"family": "Lundgren", "given": "Kalle Conneryd", "initials": "KC"}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899", "volume": "224", "issue": "1", "pages": "14-20"}, "abstract": "Whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positivity among asymptomatic subjects reflects past or future disease may be difficult to ascertain.\n\nWe tested 9449 employees at Karolinska University Hospital, Stockholm, Sweden for SARS-CoV-2 RNA and antibodies, linked the results to sick leave records, and determined associations with past or future sick leave using multinomial logistic regression.\n\nSubjects with high amounts of SARS-CoV-2 virus, indicated by polymerase chain reaction (PCR) cycle threshold (Ct) value, had the highest risk for sick leave in the 2 weeks after testing (odds ratio [OR], 11.97; 95% confidence interval [CI], 6.29-22.80) whereas subjects with low amounts of virus had the highest risk for sick leave in the 3 weeks before testing (OR, 6.31; 95% CI, 4.38-9.08). Only 2.5% of employees were SARS-CoV-2 positive while 10.5% were positive by serology and 1.2% were positive in both tests. Serology-positive subjects were not at excess risk for future sick leave (OR, 1.06; 95% CI, .71-1.57).\n\nHigh amounts of SARS-CoV-2 virus, as determined using PCR Ct values, was associated with development of sickness in the next few weeks. Results support the concept that PCR Ct may be informative when testing for SARS-CoV-2. Clinical Trials Registration. NCT04411576.", "doi": "10.1093/infdis/jiab099", "pmid": "33580261", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Research Area: High-throughput and high-content serology": null}, "xrefs": [{"db": "pmc", "key": "PMC7928785"}, {"db": "pii", "key": "6134453"}, {"db": "ClinicalTrials.gov", "key": "NCT04411576"}], "notes": [], "created": "2021-02-15T12:44:13.720Z", "modified": "2023-06-19T14:23:42.228Z"}, {"entity": "publication", "iuid": "b819f37c7eef4cc6b647ccab35dd3af4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b819f37c7eef4cc6b647ccab35dd3af4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b819f37c7eef4cc6b647ccab35dd3af4"}}, "title": "Frequency of Thrombocytopenia and Platelet Factor 4/Heparin Antibodies in Patients With Cerebral Venous Sinus Thrombosis Prior to the COVID-19 Pandemic.", "authors": [{"family": "S\u00e1nchez van Kammen", "given": "Mayte", "initials": "M"}, {"family": "Heldner", "given": "Mirjam R", "initials": "MR"}, {"family": "Brodard", "given": "Justine", "initials": "J"}, {"family": "Scutelnic", "given": "Adrian", "initials": "A"}, {"family": "Silvis", "given": "Suzanne", "initials": "S"}, {"family": "Schroeder", "given": "Verena", "initials": "V"}, {"family": "Kremer Hovinga", "given": "Johanna A", "initials": "JA"}, {"family": "Middeldorp", "given": "Saskia", "initials": "S"}, {"family": "Levi", "given": "Marcel", "initials": "M"}, {"family": "Hiltunen", "given": "Sini", "initials": "S"}, {"family": "Lindgren", "given": "Erik", "initials": "E"}, {"family": "Mansour", "given": "Maryam", "initials": "M"}, {"family": "Arauz", "given": "Antonio", "initials": "A"}, {"family": "Barboza", "given": "Miguel A", "initials": "MA"}, {"family": "Zuurbier", "given": "Susanna M", "initials": "SM"}, {"family": "Aguiar de Sousa", "given": "Diana", "initials": "D"}, {"family": "Ferro", "given": "Jose M", "initials": "JM"}, {"family": "Fischer", "given": "Urs", "initials": "U"}, {"family": "Field", "given": "Thalia S", "initials": "TS"}, {"family": "Jood", "given": "Katarina", "initials": "K"}, {"family": "Tatlisumak", "given": "Turgut", "initials": "T"}, {"family": "Putaala", "given": "Jukka", "initials": "J"}, {"family": "Arnold", "given": "Marcel", "initials": "M"}, {"family": "Coutinho", "given": "Jonathan M", "initials": "JM"}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484"}, "abstract": "Cases of cerebral venous sinus thrombosis in combination with thrombocytopenia have recently been reported within 4 to 28 days of vaccination with the ChAdOx1 nCov-19 (AstraZeneca/Oxford) and Ad.26.COV2.S (Janssen/Johnson & Johnson) COVID-19 vaccines. An immune-mediated response associated with platelet factor 4/heparin antibodies has been proposed as the underlying pathomechanism.\n\nTo determine the frequencies of admission thrombocytopenia, heparin-induced thrombocytopenia, and presence of platelet factor 4/heparin antibodies in patients diagnosed with cerebral venous sinus thrombosis prior to the COVID-19 pandemic.\n\nThis was a descriptive analysis of a retrospective sample of consecutive patients diagnosed with cerebral venous sinus thrombosis between January 1987 and March 2018 from 7 hospitals participating in the International Cerebral Venous Sinus Thrombosis Consortium from Finland, the Netherlands, Switzerland, Sweden, Mexico, Iran, and Costa Rica. Of 952 patients, 865 with available baseline platelet count were included. In a subset of 93 patients, frozen plasma samples collected during a previous study between September 2009 and February 2016 were analyzed for the presence of platelet factor 4/heparin antibodies.\n\nDiagnosis of cerebral venous sinus thrombosis.\n\nFrequencies of admission thrombocytopenia (platelet count <150 \u00d7103/\u03bcL), heparin-induced thrombocytopenia (as diagnosed by the treating physician), and platelet factor 4/heparin IgG antibodies (optical density >0.4, in a subset of patients with previously collected plasma samples).\n\nOf 865 patients (median age, 40 years [interquartile range, 29-53 years], 70% women), 73 (8.4%; 95% CI, 6.8%-10.5%) had thrombocytopenia, which was mild (100-149 \u00d7103/\u03bcL) in 52 (6.0%), moderate (50-99 \u00d7103/\u03bcL) in 17 (2.0%), and severe (<50 \u00d7103/\u03bcL) in 4 (0.5%). Heparin-induced thrombocytopenia with platelet factor 4/heparin antibodies was diagnosed in a single patient (0.1%; 95% CI, <0.1%-0.7%). Of the convenience sample of 93 patients with cerebral venous sinus thrombosis included in the laboratory analysis, 8 (9%) had thrombocytopenia, and none (95% CI, 0%-4%) had platelet factor 4/heparin antibodies.\n\nIn patients with cerebral venous sinus thrombosis prior to the COVID-19 pandemic, baseline thrombocytopenia was uncommon, and heparin-induced thrombocytopenia and platelet factor 4/heparin antibodies were rare. These findings may inform investigations of the possible association between the ChAdOx1 nCoV-19 and Ad26.COV2.S COVID-19 vaccines and cerebral venous sinus thrombosis with thrombocytopenia.", "doi": "10.1001/jama.2021.9889", "pmid": "34213527", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "2781791"}], "notes": [], "created": "2021-07-05T15:01:14.308Z", "modified": "2021-07-05T15:01:14.319Z"}, {"entity": "publication", "iuid": "510aa8ca7cef4ebdbb950f0fb539bc28", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/510aa8ca7cef4ebdbb950f0fb539bc28.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/510aa8ca7cef4ebdbb950f0fb539bc28"}}, "title": "Factors preventing SARS-CoV-2 transmission during unintentional exposure in a GP practice: a cohort study of patient contacts; Germany, 2020.", "authors": [{"family": "Boender", "given": "T Sonia", "initials": "TS", "orcid": "0000-0002-4418-3713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0d75319e2f6428c8319ffeca3f52128.json"}}, {"family": "Bender", "given": "Jennifer K", "initials": "JK", "orcid": "0000-0001-5167-3836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87d9bb9464334375911956504495bf54.json"}}, {"family": "Kr\u00fcger", "given": "Angelika", "initials": "A"}, {"family": "Michaelis", "given": "Kai", "initials": "K"}, {"family": "Buchholz", "given": "Udo", "initials": "U", "orcid": "0000-0001-6597-3995", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b447ca62aad648d5bc0fcd5246bf0ba7.json"}}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "pages": "1-17", "issn-l": null}, "abstract": null, "doi": "10.1017/S0950268821001503", "pmid": "34210375", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0950268821001503"}], "notes": [], "created": "2021-07-05T14:58:02.461Z", "modified": "2021-07-05T14:58:02.553Z"}, {"entity": "publication", "iuid": "0b39ec84783a4dff9c46a86c6c3e6882", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b39ec84783a4dff9c46a86c6c3e6882.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b39ec84783a4dff9c46a86c6c3e6882"}}, "title": "COVID-19 and the Digitalisation of Cardiovascular Training and Education-A Review of Guiding Themes for Equitable and Effective Post-graduate Telelearning.", "authors": [{"family": "Chong", "given": "Jun Hua", "initials": "JH"}, {"family": "Chahal", "given": "C Anwar A", "initials": "CAA"}, {"family": "Gupta", "given": "Ajay", "initials": "A"}, {"family": "Ricci", "given": "Fabrizio", "initials": "F"}, {"family": "Westwood", "given": "Mark", "initials": "M"}, {"family": "Pugliese", "given": "Francesca", "initials": "F"}, {"family": "Petersen", "given": "Steffen E", "initials": "SE"}, {"family": "Khanji", "given": "Mohammed Y", "initials": "MY"}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "Front Cardiovasc Med", "issn": "2297-055X", "volume": "8", "pages": "666119", "issn-l": null}, "abstract": "The coronavirus disease-2019 (COVID-19) pandemic has had an unprecedented impact leading to novel adaptations in post-graduate medical education for cardiovascular and general internal medicine. Whilst the results of initial community COVID-19 vaccination are awaited, continuation of multimodality teaching and training that incorporates telelearning will have enduring benefit to post-graduate education and will place educational establishments in good stead to nimbly respond in future pandemic-related public health emergencies. With the rise in innovative virtual learning solutions, medical educators will have to leverage technology to develop electronic educational materials and virtual courses that facilitate adult learning. Technology-enabled virtual learning is thus a timely progression of hybrid classroom initiatives that are already adopted to varying degrees, with a need for faculty to serve as subject matter experts, to host and moderate online discussions, and to provide feedback and overall mentorship. As an extension from existing efforts, simulation-based teaching (SBT) and learning and the use of mixed reality technology should also form a greater core in the cardiovascular medicine curriculum. We highlight five foundational themes for building a successful e-learning model in cardiovascular and general post-graduate medical training: (1) digital solutions and associated infrastructure; (2) equity in access; (3) participant engagement; (4) diversity and inclusion; and (5) patient confidentiality and governance framework. With digitalisation impacting our everyday lives and now how we teach and train in medicine, these five guiding principles provide a cognitive scaffold for careful consideration of the required ecosystem in which cardiovascular and general post-graduate medical education can effectively operate. With due consideration of various e-learning options and associated infrastructure needs; and adoption of strategies for participant engagement under sound and just governance, virtual training in medicine can be effective, inclusive and equitable through the COVID-19 era and beyond.", "doi": "10.3389/fcvm.2021.666119", "pmid": "34277728", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8283504"}], "notes": [], "created": "2021-08-05T11:13:06.304Z", "modified": "2021-08-05T11:13:06.327Z"}, {"entity": "publication", "iuid": "43b7e6f8efe34106853a4b413cf18a47", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/43b7e6f8efe34106853a4b413cf18a47.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/43b7e6f8efe34106853a4b413cf18a47"}}, "title": "Symptoms, symptom relief and support in COVID-19 patients dying in hospitals during the first pandemic wave.", "authors": [{"family": "Martinsson", "given": "Lisa", "initials": "L", "orcid": "0000-0003-4126-2675", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4341a69741544f5a98afc9620b7a698.json"}}, {"family": "Bergstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Hedman", "given": "Christel", "initials": "C"}, {"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "Lundstr\u00f6m", "given": "Staffan", "initials": "S"}], "type": "journal article", "published": "2021-07-01", "journal": {"title": "BMC Palliat Care", "issn": "1472-684X", "volume": "20", "issue": "1", "pages": "102", "issn-l": null}, "abstract": "At the time of the first wave of the COVID-19 pandemic in Sweden, little was known about how effective our regular end-of-life care strategies would be for patients dying from COVID-19 in hospitals. The aim of the study was to describe and evaluate end-of-life care for patients dying from COVID-19 in hospitals in Sweden up until up until 12 November 2020.\n\nData were collected from the Swedish Register of Palliative Care. Hospital deaths during 2020 for patients with COVID-19 were included and compared to a reference cohort of hospital patients who died during 2019. Logistic regression was used to compare the groups and to control for impact of sex, age and a diagnosis of dementia.\n\nThe COVID-19 group (1476 individuals) had a lower proportion of women and was older compared to the reference cohort (13,158 individuals), 81.8 versus 80.6 years (p < .001). Breathlessness was more commonly reported in the COVID-19 group compared to the reference cohort (72% vs 43%, p < .001). Furthermore, anxiety and delirium were more commonly and respiratory secretions, nausea and pain were less commonly reported during the last week in life in the COVID-19 group (p < .001 for all five symptoms). When present, complete relief of anxiety (p = .021), pain (p = .025) and respiratory secretions (p = .037) was more often achieved in the COVID-19 group. In the COVID-19 group, 57% had someone present at the time of death compared to 77% in the reference cohort (p < .001).\n\nThe standard medical strategies for symptom relief and end-of-life care in hospitals seemed to be acceptable. Symptoms in COVID-19 deaths in hospitals were relieved as much as or even to a higher degree than in hospitals in 2019. Importantly, though, as a result of closing the hospitals to relatives and visitors, patients dying from COVID-19 more frequently died alone, and healthcare providers were not able to substitute for absent relatives.", "doi": "10.1186/s12904-021-00785-4", "pmid": "34210312", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12904-021-00785-4"}], "notes": [], "created": "2021-07-05T14:57:39.411Z", "modified": "2021-07-05T14:57:39.464Z"}, {"entity": "publication", "iuid": "fbe1e98a162b4123b1d6a874566cf6d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fbe1e98a162b4123b1d6a874566cf6d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fbe1e98a162b4123b1d6a874566cf6d0"}}, "title": "Guidance for Health Care Leaders During the Recovery Stage of the COVID-19 Pandemic: A Consensus Statement.", "authors": [{"family": "Geerts", "given": "Jaason M", "initials": "JM"}, {"family": "Kinnair", "given": "Donna", "initials": "D"}, {"family": "Taheri", "given": "Paul", "initials": "P"}, {"family": "Abraham", "given": "Ajit", "initials": "A"}, {"family": "Ahn", "given": "Joonmo", "initials": "J"}, {"family": "Atun", "given": "Rifat", "initials": "R"}, {"family": "Barberia", "given": "Lorena", "initials": "L"}, {"family": "Best", "given": "Nigel J", "initials": "NJ"}, {"family": "Dandona", "given": "Rakhi", "initials": "R"}, {"family": "Dhahri", "given": "Adeel Abbas", "initials": "AA"}, {"family": "Emilsson", "given": "Louise", "initials": "L"}, {"family": "Free", "given": "Julian R", "initials": "JR"}, {"family": "Gardam", "given": "Michael", "initials": "M"}, {"family": "Geerts", "given": "William H", "initials": "WH"}, {"family": "Ihekweazu", "given": "Chikwe", "initials": "C"}, {"family": "Johnson", "given": "Shanthi", "initials": "S"}, {"family": "Kooijman", "given": "Allison", "initials": "A"}, {"family": "Lafontaine", "given": "Alika T", "initials": "AT"}, {"family": "Leshem", "given": "Eyal", "initials": "E"}, {"family": "Lidstone-Jones", "given": "Caroline", "initials": "C"}, {"family": "Loh", "given": "Erwin", "initials": "E"}, {"family": "Lyons", "given": "Oscar", "initials": "O"}, {"family": "Neel", "given": "Khalid Ali Fouda", "initials": "KAF"}, {"family": "Nyasulu", "given": "Peter S", "initials": "PS"}, {"family": "Razum", "given": "Oliver", "initials": "O"}, {"family": "Sabourin", "given": "H\u00e9l\u00e8ne", "initials": "H"}, {"family": "Schleifer Taylor", "given": "Jackie", "initials": "J"}, {"family": "Sharifi", "given": "Hamid", "initials": "H"}, {"family": "Stergiopoulos", "given": "Vicky", "initials": "V"}, {"family": "Sutton", "given": "Brett", "initials": "B"}, {"family": "Wu", "given": "Zunyou", "initials": "Z"}, {"family": "Bilodeau", "given": "Marc", "initials": "M"}], "type": "journal article", "published": "2021-07-01", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "volume": "4", "issue": "7", "pages": "e2120295", "issn-l": null}, "abstract": "The COVID-19 pandemic is the greatest global test of health leadership of our generation. There is an urgent need to provide guidance for leaders at all levels during the unprecedented preresolution recovery stage.\n\nTo create an evidence- and expertise-informed framework of leadership imperatives to serve as a resource to guide health and public health leaders during the postemergency stage of the pandemic.\n\nA literature search in PubMed, MEDLINE, and Embase revealed 10 910 articles published between 2000 and 2021 that included the terms leadership and variations of emergency, crisis, disaster, pandemic, COVID-19, or public health. Using the Standards for Quality Improvement Reporting Excellence reporting guideline for consensus statement development, this assessment adopted a 6-round modified Delphi approach involving 32 expert coauthors from 17 countries who participated in creating and validating a framework outlining essential leadership imperatives.\n\nThe 10 imperatives in the framework are: (1) acknowledge staff and celebrate successes; (2) provide support for staff well-being; (3) develop a clear understanding of the current local and global context, along with informed projections; (4) prepare for future emergencies (personnel, resources, protocols, contingency plans, coalitions, and training); (5) reassess priorities explicitly and regularly and provide purpose, meaning, and direction; (6) maximize team, organizational, and system performance and discuss enhancements; (7) manage the backlog of paused services and consider improvements while avoiding burnout and moral distress; (8) sustain learning, innovations, and collaborations, and imagine future possibilities; (9) provide regular communication and engender trust; and (10) in consultation with public health and fellow leaders, provide safety information and recommendations to government, other organizations, staff, and the community to improve equitable and integrated care and emergency preparedness systemwide.\n\nLeaders who most effectively implement these imperatives are ideally positioned to address urgent needs and inequalities in health systems and to cocreate with their organizations a future that best serves stakeholders and communities.", "doi": "10.1001/jamanetworkopen.2021.20295", "pmid": "34236416", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "2781729"}], "notes": [], "created": "2021-08-06T08:00:11.009Z", "modified": "2021-08-06T08:00:11.022Z"}, {"entity": "publication", "iuid": "e636443b37594ed2b682f780ac8e4390", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e636443b37594ed2b682f780ac8e4390.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e636443b37594ed2b682f780ac8e4390"}}, "title": "Fearing fear itself: Crowdsourced longitudinal data on Covid-19-related fear in Sweden.", "authors": [{"family": "Tishelman", "given": "Carol", "initials": "C", "orcid": "0000-0003-4161-0342", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1fbfdb57e5124e72bcffcce93b21fa05.json"}}, {"family": "Hultin-Rosenberg", "given": "Jonas", "initials": "J"}, {"family": "Hadders", "given": "Anna", "initials": "A"}, {"family": "Eriksson", "given": "Lars E", "initials": "LE", "orcid": "0000-0001-5121-5325", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09bec95869bc450aa97e0aa11485807e.json"}}], "type": "journal article", "published": "2021-07-01", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "7", "pages": "e0253371"}, "abstract": "The Covid-19 pandemic has had unprecedented effects on individual lives and livelihoods as well as on social, health, economic and political systems and structures across the world. This article derives from a unique collaboration between researchers and museums using rapid response crowdsourcing to document contemporary life among the general public during the pandemic crisis in Sweden.\r\n\r\nWe use qualitative analysis to explore the narrative crowdsourced submissions of the same 88 individuals at two timepoints, during the 1st and 2nd pandemic waves, about what they most fear in relation to the Covid-19 pandemic, and how their descriptions changed over time. In this self-selected group, we found that aspects they most feared generally concerned responses to the pandemic on a societal level, rather than to the Covid-19 disease itself or other health-related issues. The most salient fears included a broad array of societal issues, including general societal collapse and fears about effects on social and political interactions among people with resulting impact on political order. Notably strong support for the Swedish pandemic response was expressed, despite both national and international criticism.\r\n\r\nThis analysis fills a notable gap in research literature that lacks subjective and detailed investigation of experiences of the general public, despite recognition of the widespread effects of Covid-19 and its' management strategies. Findings address controversy about the role of experts in formulating and communicating strategy, as well as implications of human responses to existential threats. Based on this analysis, we call for broader focus on societal issues related to this existential threat and the responses to it.", "doi": "10.1371/journal.pone.0253371", "pmid": "34197498", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-13032"}], "notes": [], "created": "2021-07-05T14:32:27.688Z", "modified": "2022-11-23T08:55:43.933Z"}, {"entity": "publication", "iuid": "ff2eafd2d1ff48e0a45e97bf05326aa4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff2eafd2d1ff48e0a45e97bf05326aa4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff2eafd2d1ff48e0a45e97bf05326aa4"}}, "title": "Antimicrobial Resistance & Migrants in Sweden: Poor Living Conditions Enforced by Migration Control Policies as a Risk Factor for Optimal Public Health Management.", "authors": [{"family": "Elisabeth", "given": "Mangrio", "initials": "M"}, {"family": "Maneesh", "given": "Paul-Satyaseela", "initials": "PS"}, {"family": "Katarina", "given": "Sj\u00f6gren Forss", "initials": "SF"}, {"family": "Slobodan", "given": "Zdravkovic", "initials": "Z"}, {"family": "Michael", "given": "Strange", "initials": "S"}], "type": "journal article", "published": "2021-07-01", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "642983", "issn-l": "2296-2565"}, "abstract": "Infectious diseases exacerbated by Antimicrobial Resistance (AMR) are of increasing concern in Sweden, with multi-drug resistant strains associated with new resistance mechanisms that are emerging and spreading worldwide. Existing research has identified that sub-optimal living conditions and poor access to healthcare are significant factors in the spread and incubation of AMR strains. The article considers this linkage and the effort to control the spread of AMR in relation to migrants, highlighting deficiencies in public policy where such individuals are often increasingly exposed to those conditions that exacerbate AMR. In many of the richest countries, those conditions are not accidental, but often direct goals of policies designed with the goal of deterring migrants from staying within host countries. Without engaging with the politics around migration control, the article points to urgent need for more holistic assessment of all public policies that may, however unintentionally, undermine AMR control through worsening living conditions for vulnerable groups. The consequences of prioritizing policies meant to deliberately worsen the living conditions of migrants over avoiding those conditions that accelerate AMR spread, are today made ever apparent where new AMR strains have the potential to dwarf the societal effects of the current Covid-19 pandemic.", "doi": "10.3389/fpubh.2021.642983", "pmid": "34277534", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8281056"}], "notes": [], "created": "2021-08-05T11:13:39.031Z", "modified": "2021-08-05T11:14:00.826Z"}, {"entity": "publication", "iuid": "5392c61b27ca4aa7a750555622e66d75", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5392c61b27ca4aa7a750555622e66d75.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5392c61b27ca4aa7a750555622e66d75"}}, "title": "A Biased Analysis of the Swedish Management of Covid-19.", "authors": [{"family": "Nilson", "given": "Finn", "initials": "F"}], "type": "journal article", "published": "2021-07-01", "journal": {"title": "Health Policy Technol", "issn": "2211-8837", "pages": "100542", "issn-l": null}, "abstract": null, "doi": "10.1016/j.hlpt.2021.100542", "pmid": "34226863", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2211-8837(21)00065-4"}, {"db": "pmc", "key": "PMC8245297"}], "notes": [], "created": "2021-08-06T08:40:52.431Z", "modified": "2021-08-06T08:40:52.442Z"}, {"entity": "publication", "iuid": "1513bb866e3e43a8874229b2b52a121b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1513bb866e3e43a8874229b2b52a121b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1513bb866e3e43a8874229b2b52a121b"}}, "title": "Waterborne outbreak in a rural area in Greece during the COVID-19 pandemic: contribution of community pharmacies.", "authors": [{"family": "Mellou", "given": "Kassiani", "initials": "K"}, {"family": "Sideroglou", "given": "Theologia", "initials": "T"}, {"family": "Kefaloudi", "given": "Chrysovalanti", "initials": "C"}, {"family": "Tryfinopoulou", "given": "Kyriaki", "initials": "K"}, {"family": "Chrysostomou", "given": "Anthi", "initials": "A"}, {"family": "Mandilara", "given": "Georgia", "initials": "G"}, {"family": "Pavlaki", "given": "Maria", "initials": "M"}, {"family": "Maltezou", "given": "Helena C", "initials": "HC"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Rural Remote Health", "issn": "1445-6354", "volume": "21", "issue": "3", "pages": "6630", "issn-l": null}, "abstract": "On 15 June 2020, the National Public Health Organization was informed about the identification of two cases of Escherichia coli &Omicron;157 infection in a small town in the Peloponnese Region in Greece and we suspected an outbreak.\n\nWe asked the local pharmacist to assist us to verify the outbreak by providing the daily number of over-the-counter anti-diarrheal drugs sold from 20 May 2020 onwards. The pharmacist asked customers with gastroenteritis to submit stool samples at the local hospital. Samples were tested for 22 pathogens. We conducted a 1 : 1 case-control study. Cases and controls were retrieved from the pharmacy client list. Chlorination records of the water supply system were retrieved, and water samples were tested for microbiological indicators and viruses.\n\nThe increased number of sales of anti-diarrheal drugs verified the outbreak. Overall, 58 cases and 57 controls were recruited for the study. Tap water consumption (odds ratio (OR)=10.9, 95% confidence interval (CI)=3.1-38.0, p<0.001) and consumption of ice cubes made from tap water (OR=39.3, 95%CI=10.3-150.9, p<0.001) were independently associated with gastroenteritis occurrence. Eleven stool samples were tested; one was positive for shigatoxin-producing E. coli, one for enteropathogenic E. coli, four for E. coli O157 and one for Salmonella spp. Four samples tested negative. Five water samples collected on 18 June tested negative. The residual chlorine on 5 and 14 June ranged from 0.12 mg/L to 0.14 mg/L.\n\nThis was the first investigation of a waterborne outbreak in Greece performed with the collaboration of a local pharmacy. The COVID-19 pandemic favored the use of alternative resources and channels of communication with the local population, which can also be used in the future, especially in remote areas of the country.", "doi": "10.22605/RRH6630", "pmid": "34320325", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6630"}], "notes": [], "created": "2021-08-05T06:46:48.191Z", "modified": "2021-08-05T06:47:13.916Z"}, {"entity": "publication", "iuid": "9fdc18bf13a640e587387b79dde9daad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9fdc18bf13a640e587387b79dde9daad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9fdc18bf13a640e587387b79dde9daad"}}, "title": "Vaccine effectiveness against symptomatic SARS-CoV-2 infection in adults aged 65 years and older in primary care: I-MOVE-COVID-19 project, Europe, December 2020 to May 2021.", "authors": [{"family": "Kissling", "given": "Esther", "initials": "E"}, {"family": "Hooiveld", "given": "Mariette", "initials": "M"}, {"family": "Sandonis Mart\u00edn", "given": "Virginia", "initials": "V"}, {"family": "Mart\u00ednez-Baz", "given": "Iv\u00e1n", "initials": "I"}, {"family": "William", "given": "Naoma", "initials": "N"}, {"family": "Vilcu", "given": "Ana-Maria", "initials": "AM"}, {"family": "Mazagatos", "given": "Clara", "initials": "C"}, {"family": "Domegan", "given": "Lisa", "initials": "L"}, {"family": "de Lusignan", "given": "Simon", "initials": "S"}, {"family": "Meijer", "given": "Adam", "initials": "A"}, {"family": "Machado", "given": "Ausenda", "initials": "A"}, {"family": "Brytting", "given": "Mia", "initials": "M"}, {"family": "Casado", "given": "Itziar", "initials": "I"}, {"family": "Murray", "given": "Josephine-L K", "initials": "JK"}, {"family": "Belhillil", "given": "Sylvie", "initials": "S"}, {"family": "Larrauri", "given": "Amparo", "initials": "A"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}, {"family": "Tsang", "given": "Ruby", "initials": "R"}, {"family": "de Lange", "given": "Marit", "initials": "M"}, {"family": "Rodrigues", "given": "Ana Paula", "initials": "AP"}, {"family": "Riess", "given": "Maximilian", "initials": "M"}, {"family": "Castilla", "given": "Jes\u00fas", "initials": "J"}, {"family": "Hamilton", "given": "Mark", "initials": "M"}, {"family": "Falchi", "given": "Alessandra", "initials": "A"}, {"family": "Pozo", "given": "Francisco", "initials": "F"}, {"family": "Dunford", "given": "Linda", "initials": "L"}, {"family": "Cogdale", "given": "Jade", "initials": "J"}, {"family": "Jansen", "given": "Tessa", "initials": "T"}, {"family": "Guiomar", "given": "Raquel", "initials": "R"}, {"family": "Enkirch", "given": "Theresa", "initials": "T"}, {"family": "Burgui", "given": "Cristina", "initials": "C"}, {"family": "Sigerson", "given": "Debbie", "initials": "D"}, {"family": "Blanchon", "given": "Thierry", "initials": "T"}, {"family": "Mart\u00ednez Ochoa", "given": "Eva Mar\u00eda", "initials": "EM"}, {"family": "Connell", "given": "Jeff", "initials": "J"}, {"family": "Ellis", "given": "Joanna", "initials": "J"}, {"family": "van Gageldonk-Lafeber", "given": "Rianne", "initials": "R"}, {"family": "Kislaya", "given": "Irina", "initials": "I"}, {"family": "Rose", "given": "Angela Mc", "initials": "AM"}, {"family": "Valenciano", "given": "Marta", "initials": "M"}, {"family": "I-MOVE-COVID-19 primary care study team", "given": "", "initials": ""}, {"family": "I-MOVE-COVID-19 primary care study team (in addition to authors above)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "29", "issn-l": null}, "abstract": "We measured COVID-19 vaccine effectiveness (VE) against symptomatic SARS-CoV-2 infection at primary care/outpatient level among adults \u2265 65 years old using a multicentre test-negative design in eight European countries. We included 592 SARS-CoV-2 cases and 4,372 test-negative controls in the main analysis. The VE was 62% (95% CI: 45-74) for one dose only and 89% (95% CI: 79-94) for complete vaccination. COVID-19 vaccines provide good protection against COVID-19 presentation at primary care/outpatient level, particularly among fully vaccinated individuals.", "doi": "10.2807/1560-7917.ES.2021.26.29.2100670", "pmid": "34296676", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8299744"}], "notes": [], "created": "2021-08-05T07:11:21.985Z", "modified": "2021-08-05T07:11:21.998Z"}, {"entity": "publication", "iuid": "cbf18a605ecd4c1da82f040646d0ddc0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cbf18a605ecd4c1da82f040646d0ddc0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cbf18a605ecd4c1da82f040646d0ddc0"}}, "title": "The risk for a new COVID-19 wave and how it depends on R 0, the current immunity level and current restrictions.", "authors": [{"family": "Britton", "given": "Tom", "initials": "T", "orcid": "0000-0002-9228-7357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3953e83bbffb428ab0a02f335979acb2.json"}}, {"family": "Trapman", "given": "Pieter", "initials": "P", "orcid": "0000-0003-0569-1659", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a2df9c9216143cd8219de8687414709.json"}}, {"family": "Ball", "given": "Frank", "initials": "F"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "R Soc Open Sci", "issn": "2054-5703", "issn-l": null, "volume": "8", "issue": "7", "pages": "210386"}, "abstract": "The COVID-19 pandemic has hit different regions differently. The current disease-induced immunity level \u00ee in a region approximately equals the cumulative fraction infected, which primarily depends on two factors: (i) the initial potential for COVID-19 in the region (R 0), and (ii) the preventive measures put in place. Using a mathematical model including heterogeneities owing to age, social activity and susceptibility, and allowing for time-varying preventive measures, the risk for a new epidemic wave and its doubling time are investigated. Focus lies on quantifying the minimal overall effect of preventive measures p Min needed to prevent a future outbreak. It is shown that \u00ee plays a more influential roll than when immunity is obtained from vaccination. Secondly, by comparing regions with different R 0 and \u00ee it is shown that regions with lower R 0 and low \u00ee may need higher preventive measures (p Min) compared with regions having higher R 0 but also higher \u00ee, even when such immunity levels are far from herd immunity. Our results are illustrated on different regions but these comparisons contain lots of uncertainty due to simplistic model assumptions and insufficient data fitting, and should accordingly be interpreted with caution.", "doi": "10.1098/rsos.210386", "pmid": "34350017", "labels": {"Funder: VR": null, "Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8316802"}, {"db": "pii", "key": "rsos210386"}, {"db": "figshare", "key": "10.6084/m9.figshare.c.5526951"}], "notes": [], "created": "2021-08-06T08:58:06.739Z", "modified": "2023-06-19T15:26:02.530Z"}, {"entity": "publication", "iuid": "a2ad894923084e0981b07ac6b16d99fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2ad894923084e0981b07ac6b16d99fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2ad894923084e0981b07ac6b16d99fc"}}, "title": "The Swedish public health response to COVID-19.", "authors": [{"family": "Tegnell", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "APMIS", "issn": "1600-0463", "volume": "129", "issue": "7", "pages": "320-323", "issn-l": null}, "abstract": "The Swedish COVID-19 response has received excessive attention, despite not having distinctively different goals or features than other countries. The overall response has included almost all sectors of society and cannot be described here. Instead, this paper provides a general, brief description of the response from a public health perspective, but hopefully it gives a somewhat more nuanced picture of the efforts to combat COVID-19 in Sweden.", "doi": "10.1111/apm.13112", "pmid": "33622025", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-25T12:27:51.068Z", "modified": "2023-01-13T13:48:34.318Z"}, {"entity": "publication", "iuid": "eb63c9661b144436af10c6bf0224e8e3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb63c9661b144436af10c6bf0224e8e3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb63c9661b144436af10c6bf0224e8e3"}}, "title": "Sustained prothrombotic changes in convalescent patients with COVID-19.", "authors": [{"family": "von Meijenfeldt", "given": "Fien A", "initials": "FA"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Lisman", "given": "Ton", "initials": "T"}], "type": "letter", "published": "2021-07-00", "journal": {"title": "Lancet Haematol", "issn": "2352-3026", "issn-l": null, "volume": "8", "issue": "7", "pages": "e475"}, "abstract": null, "doi": "10.1016/S2352-3026(21)00146-0", "pmid": "34171275", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2352-3026(21)00146-0"}], "notes": [], "created": "2021-06-28T17:59:24.200Z", "modified": "2021-06-28T17:59:50.081Z"}, {"entity": "publication", "iuid": "7f1ddb4d277a4da6a35521c3b9c47ae6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f1ddb4d277a4da6a35521c3b9c47ae6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f1ddb4d277a4da6a35521c3b9c47ae6"}}, "title": "Spatial clustering and contextual factors associated with hospitalisation and deaths due to COVID-19 in Sweden: a geospatial nationwide ecological study.", "authors": [{"family": "Fonseca-Rodr\u00edguez", "given": "Osvaldo", "initials": "O", "orcid": "0000-0002-0253-5928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52ff35d4b27c4150984ca0428976d442.json"}}, {"family": "Gustafsson", "given": "Per E", "initials": "PE"}, {"family": "San Sebasti\u00e1n", "given": "Miguel", "initials": "M"}, {"family": "Connolly", "given": "Anne-Marie Fors", "initials": "AF", "orcid": "0000-0001-9215-4047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff46cc7d9e374929a14350748727ba60.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "7", "issn-l": "2059-7908"}, "abstract": "In Sweden, thousands of hospitalisations and deaths due to COVID-19 were reported since the pandemic started. Considering the uneven spatial distribution of those severe outcomes at the municipality level, the objective of this study was, first, to identify high-risk areas for COVID-19 hospitalisations and deaths, and second, to determine the associated contextual factors with the uneven spatial distribution of both study outcomes in Sweden.\n\nThe existences of spatial autocorrelation of the standardised incidence (hospitalisations) ratio and standardised mortality ratio were investigated using Global Moran's I test. Furthermore, we applied the retrospective Poisson spatial scan statistics to identify high-risk spatial clusters. The association between the contextual demographic and socioeconomic factors and the number of hospitalisations and deaths was estimated using a quasi-Poisson generalised additive regression model.\n\nTen high-risk spatial clusters of hospitalisations and six high-risk clusters of mortality were identified in Sweden from February 2020 to October 2020. The hospitalisations and deaths were associated with three contextual variables in a multivariate model: population density (inhabitants/km2) and the proportion of immigrants (%) showed a positive association with both outcomes, while the proportion of the population aged 65+ years (%) showed a negative association.\n\nOur study identified high-risk spatial clusters for hospitalisations and deaths due to COVID-19 and the association of population density, the proportion of immigrants and the proportion of people aged 65+ years with those severe outcomes. Results indicate where public health measures must be reinforced to improve sustained and future disease control and optimise the distribution of resources.", "doi": "10.1136/bmjgh-2021-006247", "pmid": "34321234", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-006247"}, {"db": "pmc", "key": "PMC8322019"}], "notes": [], "created": "2021-08-04T17:11:28.069Z", "modified": "2021-08-04T17:11:28.132Z"}, {"entity": "publication", "iuid": "b7fbc9a0406640b780703af116bba012", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b7fbc9a0406640b780703af116bba012.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b7fbc9a0406640b780703af116bba012"}}, "title": "Spanish telemedicine data on 8 children support concept of \u2018long covid\u2019 in children", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "journal-article", "published": "2021-07-00", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "issn-l": null, "volume": "110", "issue": "7", "pages": "2284-2284"}, "abstract": "I would like to thank Drs L\u00f3pez, Grasa, Calvo and L\u00f3pez-Hortelano for their informative letter (1) where they comment on my recent paper about five children with suggested long covid (2), but also draw our attention to their Spanish-language paper on Telemedicine follow-ups for COVID-19 (3). Of note their letter in Acta Paediatrica (1) confirms that long covid often occurs in pre-adolescent and adolescent children.", "doi": "10.1111/apa.15869", "pmid": "33834529", "labels": {"Type: Other": null, "Category: Post-COVID": null}, "xrefs": [], "notes": [], "created": "2021-04-12T16:13:11.496Z", "modified": "2021-07-09T12:48:42.931Z"}, {"entity": "publication", "iuid": "d7f367ada0b544c4bc6ce0f725c010fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d7f367ada0b544c4bc6ce0f725c010fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d7f367ada0b544c4bc6ce0f725c010fc"}}, "title": "Simultaneous detection of SARS-CoV-2 and pandemic (H1N1) 2009 virus with real-time isothermal platform.", "authors": [{"family": "Yu", "given": "Lin", "initials": "L"}, {"family": "Wang", "given": "Jingyao", "initials": "J"}, {"family": "Li", "given": "Xuelong", "initials": "X"}, {"family": "Mao", "given": "Lingling", "initials": "L"}, {"family": "Sui", "given": "Yi", "initials": "Y"}, {"family": "Chen", "given": "Weihua", "initials": "W"}, {"family": "Pelechano", "given": "Vicent", "initials": "V"}, {"family": "Guo", "given": "Xing", "initials": "X"}, {"family": "Yin", "given": "Xiushan", "initials": "X"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "issn-l": null, "volume": "7", "issue": "7", "pages": "e07584"}, "abstract": "The recent ongoing outbreak of novel coronavirus SARS-CoV-2 (known as COVID-19) is a severe threat to human health worldwide. By press time, more than 3.3 million people have died from COVID-19, with many countries experiencing peaks in infections and hospitalizations. The main symptoms of infection with SARS-CoV-2 include fever, chills, coughing, shortness of breath or difficulty breathing, fatigue, muscle or body aches and pains. While the symptoms of the pandemic (H1N1) 2009 virus have many similarities to the signs and transmission routes of the novel coronavirus, e.g., fever, cough, sore throat, body aches, headache, chills and fatigue. And a few cases of serious illness, rapid progress, can appear viral pneumonia, combined with respiratory failure, multiple organ function damage, serious people can die. Therefore, there is an urgent need to develop a rapid and accurate field diagnostic method to effectively identify the two viruses and treat these early infections on time, thus helping to control the spread of the disease. Among molecular detection methods, RT-LAMP (real-time reverse transcription-loop-mediated isothermal amplification) has some advantages in pathogen detection due to its rapid, accurate and effective detection characteristics. Here, we combined the primers of the two viruses with the fluorescent probes on the RT-LAMP detection platform to detect the two viruses simultaneously. Firstly, RT-LAMP method was used respectively to detect the two viruses at different concentrations to determine the effectiveness and sensitivity of probe primers to the RNA samples. And then, the two virus samples were detected simultaneously in the same reaction tube to validate if testing for the two viruses together had an impact on the results compared to detecting alone. We verified the detection efficiency of three highly active BST variants during RT-LAMP assay. We expect that this assay can effectively and accurately distinguish COVID-19 from the pandemic (H1N1) 2009, so that these two diseases with similar symptoms can be appropriately differentiated and treated.", "doi": "10.1016/j.heliyon.2021.e07584", "pmid": "34307953", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)01687-X"}, {"db": "pmc", "key": "PMC8280398"}], "notes": [], "created": "2021-08-05T06:56:22.572Z", "modified": "2021-08-05T07:01:34.728Z"}, {"entity": "publication", "iuid": "912d74dcafbe4e84bf11743a4fb0450e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/912d74dcafbe4e84bf11743a4fb0450e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/912d74dcafbe4e84bf11743a4fb0450e"}}, "title": "Severe COVID-19 in an APS1 patient with interferon autoantibodies treated with plasmapheresis", "authors": [{"family": "Lemarquis", "given": "Andri", "initials": "A", "orcid": "0000-0001-5165-0247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e10a68ac18214c00b65b4588c115c154.json"}}, {"family": "Campbell", "given": "Tessa", "initials": "T"}, {"family": "Aranda-Guill\u00e9n", "given": "Maribel", "initials": "M"}, {"family": "Hennings", "given": "Viktoria", "initials": "V"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Wenner\u00e5s", "given": "Christine", "initials": "C"}, {"family": "Eriksson", "given": "Kristina", "initials": "K"}, {"family": "Landegren", "given": "Nils", "initials": "N"}, {"family": "Bryceson", "given": "Yenan", "initials": "Y"}, {"family": "Berg", "given": "Stefan", "initials": "S"}, {"family": "Ekwall", "given": "Olov", "initials": "O"}], "type": "journal-article", "published": "2021-07-00", "journal": {"title": "J Allergy Clin Immunol", "issn": "0091-6749", "issn-l": null, "volume": "148", "issue": "1", "pages": "96-98"}, "abstract": null, "doi": "10.1016/j.jaci.2021.03.034", "pmid": "33892926", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0091-6749(21)00556-X"}, {"db": "pmc", "key": "PMC8051851"}], "notes": [], "created": "2021-04-26T17:31:01.538Z", "modified": "2021-11-18T16:08:38.815Z"}, {"entity": "publication", "iuid": "7f22600d9ed0435997c36604a4027b70", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f22600d9ed0435997c36604a4027b70.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f22600d9ed0435997c36604a4027b70"}}, "title": "Resetting the agenda for antibiotic resistance through a health systems perspective.", "authors": [{"family": "Cars", "given": "Otto", "initials": "O"}, {"family": "Chandy", "given": "Sujith J", "initials": "SJ"}, {"family": "Mpundu", "given": "Mirfin", "initials": "M"}, {"family": "Peralta", "given": "Arturo Quizhpe", "initials": "AQ"}, {"family": "Zorzet", "given": "Anna", "initials": "A"}, {"family": "So", "given": "Anthony D", "initials": "AD"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Lancet Glob Health", "issn": "2214-109X", "volume": "9", "issue": "7", "pages": "e1022-e1027", "issn-l": null}, "abstract": "Although the individual and societal consequences of antibiotic resistance spiral upwards, coordinated action has not kept pace on a global scale. The COVID-19 pandemic has highlighted the need for resilient health systems and has resulted in an unprecedented rate of collaboration in scientific, medical, social, and political dimensions. The pandemic has also created a renewed awareness of the importance of infectious diseases and is a substantial entry point for reigniting the momentum towards containing the silent pandemic of antibiotic resistance. In this Viewpoint, we discuss the limitations in the current narrative on antibiotic resistance and how it could be improved, including concerted efforts to close essential data gaps. We discuss the need for capacity building and coordination at the national and global levels to strengthen the understanding of the importance of sustainable access to effective antibiotics for all health systems that could generate tangible links to current processes for global health and development.", "doi": "10.1016/S2214-109X(21)00163-7", "pmid": "34143980", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2214-109X(21)00163-7"}], "notes": [], "created": "2021-06-28T18:29:27.689Z", "modified": "2021-06-28T18:29:27.705Z"}, {"entity": "publication", "iuid": "edac061672b844fc99698b5d8cd78b4f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/edac061672b844fc99698b5d8cd78b4f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/edac061672b844fc99698b5d8cd78b4f"}}, "title": "Rapid diagnostic testing for SARS-CoV-2: Validation and comparison of three point-of-care antibody tests.", "authors": [{"family": "Strand", "given": "Rasmus", "initials": "R", "orcid": "0000-0002-6875-6790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32fd1184e1274c21a16cb67f4a5000de.json"}}, {"family": "Thelaus", "given": "Louise", "initials": "L"}, {"family": "Fernstr\u00f6m", "given": "Nils", "initials": "N"}, {"family": "Sunnerhagen", "given": "Torgny", "initials": "T"}, {"family": "Lindroth", "given": "Ylva", "initials": "Y"}, {"family": "Linder", "given": "Adam", "initials": "A"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "J Med Virol", "issn": "1096-9071", "volume": "93", "issue": "7", "pages": "4592-4596", "issn-l": null}, "abstract": "With the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a need for diagnostic tests has surfaced. Point-of-care (POC) antibody tests can detect immunoglobulin (Ig) G and M against SARS-CoV-2 in serum, plasma, or whole blood and give results within 15 min. Validation of the performance of such tests is needed if they are to be used in clinical practice. In this study, we evaluated three POC antibody tests. Convalescent serum samples from 47 reverse transcription-polymerase chain reaction (RT-PCR) verified patients with coronavirus disease 2019 (COVID-19) collected at least 28 days post RT-PCR diagnosis as well as 50 negative pre-COVID-19 controls were tested. The three tests (denoted the J-, N-, and Z-tests) displayed the sensitivities of 87%, 96%, and 85%, respectively, for the detection of IgG. All tests had the same specificity for IgG (98%). The tests did not differ significantly for the detection of IgG. The sensitivities for IgM were lower (15%, 67%, and 70%) and the specificities were 90%, 98%, and 90%, respectively. The positive and negative predictive values were similar among the tests. Our results indicate that these POC antibody tests might be accurate enough to use in routine clinical practice.", "doi": "10.1002/jmv.26913", "pmid": "33666238", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Proteins": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8014463"}], "notes": [], "created": "2021-03-06T10:09:55.362Z", "modified": "2021-11-18T12:47:58.452Z"}, {"entity": "publication", "iuid": "f1262619e94340d4ab08c02d5fd8f36d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1262619e94340d4ab08c02d5fd8f36d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1262619e94340d4ab08c02d5fd8f36d"}}, "title": "Privacy lost: Appropriating surveillance technology in China\u2019s fight against COVID-19", "authors": [{"family": "Liu", "given": "Jun", "initials": "J"}, {"family": "Zhao", "given": "Hui", "initials": "H"}], "type": "journal-article", "published": "2021-07-00", "journal": {"title": "Business Horizons", "issn": "0007-6813", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/j.bushor.2021.07.004", "pmid": null, "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:52:59.576Z", "modified": "2022-11-23T08:58:55.620Z"}, {"entity": "publication", "iuid": "18aa9fe62d094bfabc8c44c5c3a5e5de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18aa9fe62d094bfabc8c44c5c3a5e5de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18aa9fe62d094bfabc8c44c5c3a5e5de"}}, "title": "Monitoring lung injury with particle flow rate in LPS- and COVID-19-induced ARDS.", "authors": [{"family": "Stenlo", "given": "Martin", "initials": "M", "orcid": "0000-0001-8328-259X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/194fa048a20b4e149737bd062773b293.json"}}, {"family": "Silva", "given": "Iran A N", "initials": "IAN"}, {"family": "Hyll\u00e9n", "given": "Snejana", "initials": "S"}, {"family": "B\u00f6l\u00fckbas", "given": "Deniz A", "initials": "DA"}, {"family": "Niroomand", "given": "Anna", "initials": "A", "orcid": "0000-0002-6402-9414", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ce75bcb9bac481f93e200ea079812b4.json"}}, {"family": "Grins", "given": "Edgars", "initials": "E"}, {"family": "Ederoth", "given": "Per", "initials": "P"}, {"family": "Hallgren", "given": "Oskar", "initials": "O"}, {"family": "Pierre", "given": "Leif", "initials": "L"}, {"family": "Wagner", "given": "Darcy E", "initials": "DE", "orcid": "0000-0003-3794-1309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a62680154e2e4ae2b7cec2c44af06c9a.json"}}, {"family": "Lindstedt", "given": "Sandra", "initials": "S", "orcid": "0000-0003-4484-6473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0739b93800374fa789184d52aa753ffa.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Physiol Rep", "issn": "2051-817X", "volume": "9", "issue": "13", "pages": "e14802", "issn-l": null}, "abstract": "In severe acute respiratory distress syndrome (ARDS), extracorporeal membrane oxygenation (ECMO) is a life-prolonging treatment, especially among COVID-19 patients. Evaluation of lung injury progression is challenging with current techniques. Diagnostic imaging or invasive diagnostics are risky given the difficulties of intra-hospital transportation, contraindication of biopsies, and the potential for the spread of infections, such as in COVID-19 patients. We have recently shown that particle flow rate (PFR) from exhaled breath could be a noninvasive, early detection method for ARDS during mechanical ventilation. We hypothesized that PFR could also measure the progress of lung injury during ECMO treatment. Lipopolysaccharide (LPS) was thus used to induce ARDS in pigs under mechanical ventilation. Eight were connected to ECMO, whereas seven animals were not. In addition, six animals received sham treatment with saline. Four human patients with ECMO and ARDS were also monitored. In the pigs, as lung injury ensued, the PFR dramatically increased and a particular spike followed the establishment of ECMO in the LPS-treated animals. PFR remained elevated in all animals with no signs of lung recovery. In the human patients, in the two that recovered, PFR decreased. In the two whose lung function deteriorated while on ECMO, there was increased PFR with no sign of recovery in lung function. The present results indicate that real-time monitoring of PFR may be a new, complementary approach in the clinic for measurement of the extent of lung injury and recovery over time in ECMO patients with ARDS.", "doi": "10.14814/phy2.14802", "pmid": "34250766", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8273428"}], "notes": [], "created": "2021-08-06T07:49:20.116Z", "modified": "2021-08-06T07:49:20.217Z"}, {"entity": "publication", "iuid": "f111b8fca3e6412b8110ce03ded40ceb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f111b8fca3e6412b8110ce03ded40ceb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f111b8fca3e6412b8110ce03ded40ceb"}}, "title": "Lessons from COVID.", "authors": [{"family": "Kitson", "given": "Alison", "initials": "A", "orcid": "0000-0003-3053-8381", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7dd7640c23354063aab9385f22eaf4af.json"}}, {"family": "Huisman-de Waal", "given": "Getty", "initials": "G"}, {"family": "Muntlin", "given": "Asa", "initials": "A"}], "type": "editorial", "published": "2021-07-00", "journal": {"title": "J Adv Nurs", "issn": "1365-2648", "volume": "77", "issue": "7", "pages": "e7-e9", "issn-l": null}, "abstract": null, "doi": "10.1111/jan.14844", "pmid": "33780039", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-03-30T12:25:58.304Z", "modified": "2023-01-13T13:35:08.253Z"}, {"entity": "publication", "iuid": "774079bedc1a47c5a03107c4ae2b68e4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/774079bedc1a47c5a03107c4ae2b68e4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/774079bedc1a47c5a03107c4ae2b68e4"}}, "title": "Intrauterine vertical SARS-CoV-2 infection: a case confirming transplacental transmission followed by divergence of the viral genome.", "authors": [{"family": "Zaigham", "given": "M", "initials": "M", "orcid": "0000-0003-0129-1578", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/168018c2beee4b99868263d77bb67277.json"}}, {"family": "Holmberg", "given": "A", "initials": "A"}, {"family": "Karlberg", "given": "M L", "initials": "ML"}, {"family": "Lindsj\u00f6", "given": "O K", "initials": "OK"}, {"family": "Jokubkiene", "given": "L", "initials": "L"}, {"family": "Sandblom", "given": "J", "initials": "J"}, {"family": "Strand", "given": "A S", "initials": "AS"}, {"family": "Andersson", "given": "O", "initials": "O"}, {"family": "Hansson", "given": "S R", "initials": "SR"}, {"family": "Nord", "given": "D G", "initials": "DG"}, {"family": "Tannenberg", "given": "P", "initials": "P"}], "type": "case reports", "published": "2021-07-00", "journal": {"title": "BJOG", "issn": "1471-0528", "volume": "128", "issue": "8", "pages": "1388-1394", "issn-l": null}, "abstract": "A 27-year-old woman (gravida 2, para 1) was transported to the regional university hospital in gestational week (GW) 34 + 4 due to a three-day history of fever, abdominal pain and reduced foetal movements. She had developed a dry cough one day prior to the admission (Figure S1). The woman, was slightly overweight (BMI 27 kg/m 2 ) but otherwise healthy. She had normal antenatal check-ups and an obstetric ultrasound at GW 32 + 2 showed a normal foetal weight deviation of +8%1 .", "doi": "10.1111/1471-0528.16682", "pmid": "33638908", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8013698"}], "notes": [], "created": "2021-03-01T10:26:44.679Z", "modified": "2021-11-18T11:58:29.481Z"}, {"entity": "publication", "iuid": "04206c294cbe4fceb756221db3d0b598", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/04206c294cbe4fceb756221db3d0b598.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/04206c294cbe4fceb756221db3d0b598"}}, "title": "Impact of pathogen reduction methods on immunological properties of the COVID-19 convalescent plasma.", "authors": [{"family": "Kostin", "given": "Alexander I", "initials": "AI", "orcid": "0000-0001-7542-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a28d5c0e69df478a84d89c91d83f0068.json"}}, {"family": "Lundgren", "given": "Maria N", "initials": "MN", "orcid": "0000-0001-8081-962X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8000a3de30e4a42a2397c3561adb685.json"}}, {"family": "Bulanov", "given": "Andrey Y", "initials": "AY", "orcid": "0000-0001-6999-8145", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/739b725cb6ed4bc4a39ab94fef9c0b1a.json"}}, {"family": "Ladygina", "given": "Elena A", "initials": "EA", "orcid": "0000-0001-7343-0667", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d3950fb8d5a47528353602e7f3bc81b.json"}}, {"family": "Chirkova", "given": "Karina S", "initials": "KS", "orcid": "0000-0003-2583-9956", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a8097f7620b42d8a7f0499f13e3e079.json"}}, {"family": "Gintsburg", "given": "Alexander L", "initials": "AL", "orcid": "0000-0003-1769-5059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2431d07e4df14514832bd495b68881fb.json"}}, {"family": "Logunov", "given": "Denis Y", "initials": "DY", "orcid": "0000-0003-4035-6581", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/66576c7bb29446cba136c9d019e0dfeb.json"}}, {"family": "Dolzhikova", "given": "Inna V", "initials": "IV", "orcid": "0000-0003-2548-6142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d48dc829d0346c1bf6220c25091ee47.json"}}, {"family": "Shcheblyakov", "given": "Dmitry V", "initials": "DV", "orcid": "0000-0002-1289-3411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9966082c61f4ed29f5e6e5d9416d109.json"}}, {"family": "Borovkova", "given": "Natalia V", "initials": "NV", "orcid": "0000-0002-8897-7523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eaca90ac5bf5475abf8f994e18b79402.json"}}, {"family": "Godkov", "given": "Mikhail A", "initials": "MA", "orcid": "0000-0001-9612-6705", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83b007f636504bc7a4743146e6e897cf.json"}}, {"family": "Bazhenov", "given": "Alexey I", "initials": "AI", "orcid": "0000-0002-1926-145X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a35e87f647f4945982b3077b72e038c.json"}}, {"family": "Shustov", "given": "Valeriy V", "initials": "VV", "orcid": "0000-0002-9624-5883", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74087b1795364165b659eaa9c13071a2.json"}}, {"family": "Bogdanova", "given": "Alina S", "initials": "AS", "orcid": "0000-0002-6608-8493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04f6332b01c24d709ebffc160911f661.json"}}, {"family": "Kamalova", "given": "Alina R", "initials": "AR", "orcid": "0000-0001-8022-8491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1664eb55ddfd44f78a90ecfa31e61603.json"}}, {"family": "Ganchin", "given": "Vladimir V", "initials": "VV", "orcid": "0000-0001-9138-6479", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8282794964834c2f818f8622f18931f5.json"}}, {"family": "Dombrovskiy", "given": "Eugene A", "initials": "EA", "orcid": "0000-0002-3154-3564", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/416da0dc54b642158bfa85aff8763979.json"}}, {"family": "Volkov", "given": "Stanislav E", "initials": "SE", "orcid": "0000-0001-5289-2256", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b60e88f4ce9740b0ad315065b9fce6c5.json"}}, {"family": "Drozdova", "given": "Nataliya E", "initials": "NE", "orcid": "0000-0001-9374-6554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bac7ac296eb942a884f56fe03d385c01.json"}}, {"family": "Petrikov", "given": "Sergey S", "initials": "SS", "orcid": "0000-0003-3292-8789", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d28e63ecffcc469ca8f1bc5ec08d392b.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Vox Sang", "issn": "1423-0410", "volume": "116", "issue": "6", "pages": "665-672", "issn-l": null}, "abstract": "COVID-19 convalescent plasma is an experimental treatment against SARS-CoV-2. The aim of this study is to assess the impact of different pathogen reduction methods on the levels and virus neutralizing activity of the specific antibodies against SARS-CoV2 in convalescent plasma.\n\nA total of 140 plasma doses collected by plasmapheresis from COVID-19 convalescent donors were subjected to pathogen reduction by three methods: methylene blue (M)/visible light, riboflavin (R)/UVB and amotosalen (A)/UVA. To conduct a paired comparison, individual plasma doses were divided into 2 samples that were subjected to one of these methods. The titres of SARS-CoV2 neutralizing antibodies (NtAbs) and levels of specific immunoglobulins to RBD, S- and N-proteins of SARS-CoV-2 were measured before and after pathogen reduction.\n\nThe methods reduced NtAbs titres differently: among units with the initial titre 80 or above, 81% of units remained unchanged and 19% decreased by one step after methylene blue; 60% were unchanged and 40% decreased by one step after amotosalen; after riboflavin 43% were unchanged and 50% (7%, respectively) had a one-step (two-step, respectively) decrease. Paired two-sample comparisons (M vs. A, M vs. R and A vs. R) revealed that the largest statistically significant decrease in quantity and activity of the specific antibodies resulted from the riboflavin treatment.\n\nPathogen reduction with methylene blue or with amotosalen provides the greater likelihood of preserving the immunological properties of the COVID-19 convalescent plasma compared to riboflavin.", "doi": "10.1111/vox.13056", "pmid": "33734455", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8250394"}], "notes": [], "created": "2021-03-22T10:49:56.136Z", "modified": "2021-11-18T13:46:53.300Z"}, {"entity": "publication", "iuid": "5961f60ecefc450babce1e2642161dc1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5961f60ecefc450babce1e2642161dc1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5961f60ecefc450babce1e2642161dc1"}}, "title": "Higher vs lower doses of dexamethasone in patients with COVID\u201019 and severe hypoxia (COVID STEROID 2) trial: Protocol and statistical analysis plan", "authors": [{"family": "Munch", "given": "MW", "initials": "M", "orcid": "0000-0003-1127-9599", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd56f64f991042da935f6f3836e087b0.json"}}, {"family": "Granholm", "given": "Anders", "initials": "A"}, {"family": "Myatra", "given": "SN", "initials": "S"}, {"family": "Vijayaraghavan", "given": "BKT", "initials": "B"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Wahlin", "given": "RR", "initials": "R"}, {"family": "Jakob", "given": "Stephan M", "initials": "SM"}, {"family": "Cioccari", "given": "Luca", "initials": "L"}, {"family": "Kj\u00e6r", "given": "MN", "initials": "M", "orcid": "0000-0002-6536-0504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df8fa07399b448a5b689089e505dab58.json"}}, {"family": "Vesterlund", "given": "GK", "initials": "G", "orcid": "0000-0001-5221-3938", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6eb5ff4bc5054887bfac267b8c8af411.json"}}, {"family": "Meyhoff", "given": "TS", "initials": "T", "orcid": "0000-0002-1840-1596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/766fe5fd044944faabf6a96e8d6a72f0.json"}}, {"family": "Helleberg", "given": "Marie", "initials": "M"}, {"family": "M\u00f8ller", "given": "MH", "initials": "M", "orcid": "0000-0002-6378-9673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1cf88aaa5c9436a8e70ddfe39cfe4e8.json"}}, {"family": "Benfield", "given": "Thomas", "initials": "T"}, {"family": "Venkatesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Hammond", "given": "Naomi", "initials": "N"}, {"family": "Micallef", "given": "Sharon", "initials": "S"}, {"family": "Bassi", "given": "Abhinav", "initials": "A"}, {"family": "John", "given": "Oommen", "initials": "O"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Kristiansen", "given": "KT", "initials": "K"}, {"family": "Ulrik", "given": "CS", "initials": "C"}, {"family": "J\u00f8rgensen", "given": "VL", "initials": "V"}, {"family": "Smitt", "given": "Margit", "initials": "M"}, {"family": "Bestle", "given": "Morten H", "initials": "MH"}, {"family": "Andreasen", "given": "AS", "initials": "A"}, {"family": "Poulsen", "given": "LM", "initials": "L"}, {"family": "Rasmussen", "given": "BS", "initials": "B", "orcid": "0000-0003-2190-145X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa66146077394afea60f71d4be6daf06.json"}}, {"family": "Br\u00f8chner", "given": "AC", "initials": "A"}, {"family": "Str\u00f8m", "given": "Thomas", "initials": "T"}, {"family": "M\u00f8ller", "given": "Anders", "initials": "A"}, {"family": "Khan", "given": "MS", "initials": "M"}, {"family": "Padmanaban", "given": "Ajay", "initials": "A"}, {"family": "Divatia", "given": "JV", "initials": "J"}, {"family": "Saseedharan", "given": "Sanjith", "initials": "S"}, {"family": "Borawake", "given": "Kapil", "initials": "K"}, {"family": "Kapadia", "given": "Farhad", "initials": "F"}, {"family": "Dixit", "given": "Subhal", "initials": "S"}, {"family": "Chawla", "given": "Rajesh", "initials": "R"}, {"family": "Shukla", "given": "Urvi", "initials": "U"}, {"family": "Amin", "given": "Pravin", "initials": "P"}, {"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Lange", "given": "Theis", "initials": "T"}, {"family": "Perner", "given": "Anders", "initials": "A", "orcid": "0000-0002-4668-0123", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5d5120bc69c433f9df2b929d6be905a.json"}}], "type": "journal-article", "published": "2021-07-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "0001-5172", "volume": "65", "issue": "6", "pages": "834-845", "issn-l": null}, "abstract": null, "doi": "10.1111/aas.13795", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-15T07:49:08.383Z", "modified": "2021-06-18T12:04:56.569Z"}, {"entity": "publication", "iuid": "f2856ad6b78843f286c681e2ad60aa62", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f2856ad6b78843f286c681e2ad60aa62.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f2856ad6b78843f286c681e2ad60aa62"}}, "title": "Gambling and self-reported changes in gambling during COVID-19 in web survey respondents in Denmark.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": "7", "issue": "7", "pages": "e07506", "issn-l": null}, "abstract": "Problem gambling is among the public health hazards which may increase due to the COVID-19 pandemic and its consequences on society. Results from a few countries have hitherto been diverse with respect to gambling during the pandemic. The present study aimed to study gambling behaviors during COVID-19 in Denmark, with the same methodology as previously used in Sweden, and also to provide a comparison to previously published Swedish data. A web survey was answered by 2,012 individuals, from December 2, to December 10, 2020. Four percent reported increased gambling habits, and three percent reported decreased gambling, during COVID-19. Self-reported increase in gambling was associated with spending more time at home, mental distress, and higher gambling severity. Prevalence of self-reported, increased gaming during COVID-19 was significantly lower in Denmark than in Sweden. Although the overall changes in gambling patterns during COVID-19 may be limited, people who increase their gambling during the pandemic may be at particular risk. Stakeholders should pay attention to individuals who report altered gambling habits during the pandemic.", "doi": "10.1016/j.heliyon.2021.e07506", "pmid": "34337174", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)01609-1"}, {"db": "pmc", "key": "PMC8318852"}], "notes": [], "created": "2021-08-04T10:11:54.307Z", "modified": "2021-08-04T10:12:15.975Z"}, {"entity": "publication", "iuid": "97ef8fbfc7b64b0b847e5d76a17538e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/97ef8fbfc7b64b0b847e5d76a17538e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/97ef8fbfc7b64b0b847e5d76a17538e1"}}, "title": "Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry.", "authors": [{"family": "Strangfeld", "given": "Anja", "initials": "A", "orcid": "0000-0002-6233-022X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/644005e83dff44b7bdca5d2b818e17d5.json"}}, {"family": "Sch\u00e4fer", "given": "Martin", "initials": "M"}, {"family": "Gianfrancesco", "given": "Milena A", "initials": "MA"}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S"}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Ljung", "given": "Lotta", "initials": "L", "orcid": "0000-0001-8999-0925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/709689ef8ef54a80a79c7db9ad2d9de8.json"}}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Richez", "given": "Christophe", "initials": "C", "orcid": "0000-0002-3029-8739", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eade13f96ed49bd8a656c07a8f6ced8.json"}}, {"family": "Santos", "given": "Maria J", "initials": "MJ", "orcid": "0000-0002-7946-1365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d031d58f434247fd83359ee0c7602db5.json"}}, {"family": "Schmajuk", "given": "Gabriela", "initials": "G"}, {"family": "Scir\u00e8", "given": "Carlo A", "initials": "CA", "orcid": "0000-0001-7451-0271", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76ebc6c1acb94b2780a38dc4e8aea708.json"}}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA"}, {"family": "Sufka", "given": "Paul", "initials": "P"}, {"family": "Thomas", "given": "Thierry", "initials": "T"}, {"family": "Trupin", "given": "Laura", "initials": "L"}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Al-Adely", "given": "Sarah", "initials": "S"}, {"family": "Bachiller-Corral", "given": "Javier", "initials": "J", "orcid": "0000-0001-8954-209X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a1aaa97213840fe8ab9108b4574e9a5.json"}}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Cacoub", "given": "Patrice", "initials": "P"}, {"family": "Carmona", "given": "Loreto", "initials": "L", "orcid": "0000-0002-4401-2551", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/798721bfd6a14e2f95267a56c5750ebe.json"}}, {"family": "Costello", "given": "Ruth", "initials": "R", "orcid": "0000-0003-2709-6666", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c0fe69f61b54ab89f9a3de852f872a8.json"}}, {"family": "Costello", "given": "Wendy", "initials": "W"}, {"family": "Gossec", "given": "Laure", "initials": "L", "orcid": "0000-0002-4528-310X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be93914dbc9b4abb936cbcaf202de05f.json"}}, {"family": "Grainger", "given": "Rebecca", "initials": "R"}, {"family": "Hachulla", "given": "Eric", "initials": "E", "orcid": "0000-0001-7432-847X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20bee300407547bc8d669593ff7b2764.json"}}, {"family": "Hasseli", "given": "Rebecca", "initials": "R", "orcid": "0000-0002-2982-8253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aac4e1f1ceab4e72bb816a40c2f80c44.json"}}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS", "orcid": "0000-0003-0786-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d99dc166f48d4af7b8e46dc999c7444b.json"}}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL", "orcid": "0000-0001-8242-9262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9ad49b088eb467ba6d1ca1559b88047.json"}}, {"family": "Izadi", "given": "Zara", "initials": "Z"}, {"family": "Jacobsohn", "given": "Lindsay", "initials": "L"}, {"family": "Katz", "given": "Patricia", "initials": "P"}, {"family": "Kearsley-Fleet", "given": "Lianne", "initials": "L", "orcid": "0000-0003-0377-1575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9cc64aac266462baf67998b3d49c6f7.json"}}, {"family": "Robinson", "given": "Philip C", "initials": "PC", "orcid": "0000-0002-3156-3418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/950b622d31724172817ccde09902d215.json"}}, {"family": "Yazdany", "given": "Jinoos", "initials": "J"}, {"family": "Machado", "given": "Pedro M", "initials": "PM", "orcid": "0000-0002-8411-7972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef40d1eea57946e4a37d2e92a02a47cd.json"}}, {"family": "COVID-19 Global Rheumatology Alliance", "given": "", "initials": ""}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Ann Rheum Dis", "issn": "1468-2060", "volume": "80", "issue": "7", "pages": "930-942", "issn-l": null}, "abstract": "To determine factors associated with COVID-19-related death in people with rheumatic diseases.\n\nPhysician-reported registry of adults with rheumatic disease and confirmed or presumptive COVID-19 (from 24 March to 1 July 2020). The primary outcome was COVID-19-related death. Age, sex, smoking status, comorbidities, rheumatic disease diagnosis, disease activity and medications were included as covariates in multivariable logistic regression models. Analyses were further stratified according to rheumatic disease category.\n\nOf 3729 patients (mean age 57 years, 68% female), 390 (10.5%) died. Independent factors associated with COVID-19-related death were age (66-75 years: OR 3.00, 95% CI 2.13 to 4.22; >75 years: 6.18, 4.47 to 8.53; both vs \u226465 years), male sex (1.46, 1.11 to 1.91), hypertension combined with cardiovascular disease (1.89, 1.31 to 2.73), chronic lung disease (1.68, 1.26 to 2.25) and prednisolone-equivalent dosage >10 mg/day (1.69, 1.18 to 2.41; vs no glucocorticoid intake). Moderate/high disease activity (vs remission/low disease activity) was associated with higher odds of death (1.87, 1.27 to 2.77). Rituximab (4.04, 2.32 to 7.03), sulfasalazine (3.60, 1.66 to 7.78), immunosuppressants (azathioprine, cyclophosphamide, ciclosporin, mycophenolate or tacrolimus: 2.22, 1.43 to 3.46) and not receiving any disease-modifying anti-rheumatic drug (DMARD) (2.11, 1.48 to 3.01) were associated with higher odds of death, compared with methotrexate monotherapy. Other synthetic/biological DMARDs were not associated with COVID-19-related death.\n\nAmong people with rheumatic disease, COVID-19-related death was associated with known general factors (older age, male sex and specific comorbidities) and disease-specific factors (disease activity and specific medications). The association with moderate/high disease activity highlights the importance of adequate disease control with DMARDs, preferably without increasing glucocorticoid dosages. Caution may be required with rituximab, sulfasalazine and some immunosuppressants.", "doi": "10.1136/annrheumdis-2020-219498", "pmid": "33504483", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7843211"}, {"db": "pii", "key": "annrheumdis-2020-219498"}], "notes": [], "created": "2021-01-29T15:13:40.304Z", "modified": "2023-06-19T14:10:28.427Z"}, {"entity": "publication", "iuid": "facda1393fe04db9932c289dd0bcd4f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/facda1393fe04db9932c289dd0bcd4f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/facda1393fe04db9932c289dd0bcd4f0"}}, "title": "Editor's Choice - The Impact of Covid-19 on Vascular Procedures in Sweden 2020.", "authors": [{"family": "Bj\u00f6rses", "given": "Katarina", "initials": "K"}, {"family": "Blomgren", "given": "Lena", "initials": "L"}, {"family": "Holsti", "given": "Mari", "initials": "M"}, {"family": "Jonsson", "given": "Magnus", "initials": "M"}, {"family": "Smidfelt", "given": "Kristian", "initials": "K"}, {"family": "Mani", "given": "Kevin", "initials": "K"}], "type": "letter", "published": "2021-07-00", "journal": {"title": "Eur J Vasc Endovasc Surg", "issn": "1532-2165", "issn-l": "1078-5884", "volume": "62", "issue": "1", "pages": "136-137"}, "abstract": null, "doi": "10.1016/j.ejvs.2021.04.027", "pmid": "34053841", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8098046"}, {"db": "pii", "key": "S1078-5884(21)00372-5"}], "notes": [], "created": "2021-06-04T11:30:05.360Z", "modified": "2023-01-13T14:48:38.476Z"}, {"entity": "publication", "iuid": "3f5db6dd1efd4733beb5d4486525868a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f5db6dd1efd4733beb5d4486525868a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f5db6dd1efd4733beb5d4486525868a"}}, "title": "Critical illness polyneuropathy, myopathy and neuronal biomarkers in COVID-19 patients: A prospective study.", "authors": [{"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "F\u00e4llmar", "given": "David", "initials": "D"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Ashton", "given": "Nicholas", "initials": "N"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Punga", "given": "Anna Rostedt", "initials": "AR"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Clin Neurophysiol", "issn": "1872-8952", "issn-l": null, "volume": "132", "issue": "7", "pages": "1733-1740"}, "abstract": "The aim was to characterize the electrophysiological features and plasma biomarkers of critical illness polyneuropathy (CIN) and myopathy (CIM) in coronavirus disease 2019 (COVID-19) patients with intensive care unit acquired weakness (ICUAW).\n\nAn observational ICU cohort study including adult patients admitted to the ICU at Uppsala University Hospital, Uppsala, Sweden, from March 13th to June 8th 2020. We compared the clinical, electrophysiological and plasma biomarker data between COVID-19 patients who developed CIN/CIM and those who did not. Electrophysiological characteristics were also compared between COVID-19 and non-COVID-19 ICU patients.\n\n111 COVID-19 patients were included, 11 of whom developed CIN/CIM. Patients with CIN/CIM had more severe illness; longer ICU stay, more thromboembolic events and were more frequently treated with invasive ventilation for longer than 2 weeks. In particular CIN was more frequent among COVID-19 patients with ICUAW (50%) compared with a non-COVID-19 cohort (0%, p = 0.008). Neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAp) levels were higher in the CIN/CIM group compared with those that did not develop CIN/CIM (both p = 0.001) and correlated with nerve amplitudes.\n\nCIN/CIM was more prevalent among COVID-19 ICU patients with severe illness.\n\nCOVID-19 patients who later developed CIN/CIM had significantly higher NfL and GFAp in the early phase of ICU care, suggesting their potential as predictive biomarkers for CIN/CIM.", "doi": "10.1016/j.clinph.2021.03.016", "pmid": "33875374", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "S1388-2457(21)00489-2"}, {"db": "pmc", "key": "PMC8012169"}], "notes": [], "created": "2021-04-20T17:48:37.525Z", "modified": "2021-12-12T18:08:09.693Z"}, {"entity": "publication", "iuid": "c87c3f16e8944d079f1a4fa0db3fd07d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c87c3f16e8944d079f1a4fa0db3fd07d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c87c3f16e8944d079f1a4fa0db3fd07d"}}, "title": "Central pulmonary embolism in patients with Covid-19.", "authors": [{"family": "Nordberg", "given": "Martin", "initials": "M"}, {"family": "Bankler", "given": "Sara", "initials": "S"}, {"family": "Everhov", "given": "\u00c5sa H", "initials": "\u00c5H"}, {"family": "Saraste", "given": "Deborah", "initials": "D", "orcid": "0000-0002-2931-2652", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27593429159d4605b8d3835a4c479c9d.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "volume": "53", "issue": "7", "pages": "513-520", "issn-l": "2374-4235"}, "abstract": "The purpose was to evaluate central pulmonary embolism (PE) in patients with Covid-19. The association with severe radiological pulmonary changes, prophylactic anticoagulation and ICU care was assessed.\n\nFrom 1 March until 31 May 2020, all in-hospital patients with a positive PCR for SARS-CoV-2-RNA and PE diagnosed with computed tomography pulmonary angiography were identified through diagnostic codes in medical charts. PE was characterised as central/peripheral and unilateral/bilateral. Covid-19 related lung changes were evaluated scoring the proportion of affected lung (max-score score 25) for all five lobes in both lungs. ICU and non-ICU patients were included and anticoagulant regimens were assessed.\n\nOf 1162 patients with Covid-19, 41 were diagnosed with PE (cumulative incidence 3.5%), and of these 63.4% (=overall 2.2%) had central PE. PE on admission was present in 46.3%. No differences were seen in the distribution of central vs. peripheral PE in relation to prophylactic anticoagulation (p=.317). Of ICU patients 82.4% were diagnosed with central PE compared to 50.0% among non-ICU patients (p=.05). No association was observed between the presence of central PE and the extent of radiological Covid-19 changes (p=.451). Mild (0-12 p) and severe (13-25 p) pulmonary changes were seen in 63.4% and 36.6% of patients respectively.\n\nOverall, and especially in ICU-patients, a high proportion of central PE was seen and many were diagnosed at admission. No association between central PE and prophylactic anticoagulation, or the extent of pulmonary Covid-19 changes was observed.", "doi": "10.1080/23744235.2021.1896030", "pmid": "33682582", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-09T15:36:23.979Z", "modified": "2021-11-18T12:49:39.668Z"}, {"entity": "publication", "iuid": "7a1bbe984f604d3f94c80907b7a3fcd1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a1bbe984f604d3f94c80907b7a3fcd1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a1bbe984f604d3f94c80907b7a3fcd1"}}, "title": "COVIDomic: A multi-modal cloud-based platform for identification of risk factors associated with COVID-19 severity.", "authors": [{"family": "Naumov", "given": "Vladimir", "initials": "V", "orcid": "0000-0003-3863-4925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3908575922db49b385f95202accd91ab.json"}}, {"family": "Putin", "given": "Evgeny", "initials": "E", "orcid": "0000-0002-3012-9708", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75cf694692d94af78fa6d20713e4be85.json"}}, {"family": "Pushkov", "given": "Stefan", "initials": "S", "orcid": "0000-0002-1768-394X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fbbf0cd7a6a43818a2b308693edf670.json"}}, {"family": "Kozlova", "given": "Ekaterina", "initials": "E", "orcid": "0000-0003-2737-3694", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c21fab8ed9d743a0b2c898e11480003e.json"}}, {"family": "Romantsov", "given": "Konstantin", "initials": "K", "orcid": "0000-0003-0731-8575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76be3a4ea6964c7d81744a82113acde0.json"}}, {"family": "Kalashnikov", "given": "Alexander", "initials": "A"}, {"family": "Galkin", "given": "Fedor", "initials": "F", "orcid": "0000-0002-5709-9529", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/66f24623a3c14040b179ba9b0fd994ee.json"}}, {"family": "Tihonova", "given": "Nina", "initials": "N"}, {"family": "Shneyderman", "given": "Anastasia", "initials": "A"}, {"family": "Galkin", "given": "Egor", "initials": "E", "orcid": "0000-0001-9636-5706", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd7329726357486b93f9c01eb249c917.json"}}, {"family": "Zinkevich", "given": "Arsenii", "initials": "A"}, {"family": "Cope", "given": "Stephanie M", "initials": "SM"}, {"family": "Sethuraman", "given": "Ramanathan", "initials": "R"}, {"family": "Oprea", "given": "Tudor I", "initials": "TI", "orcid": "0000-0002-6195-6976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c480e6e946bd4c43ac430fd0309df71e.json"}}, {"family": "Pearson", "given": "Alexander T", "initials": "AT", "orcid": "0000-0003-2801-7456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/649fa71af7a0428fbd8f8d10111089c6.json"}}, {"family": "Tay", "given": "Savas", "initials": "S", "orcid": "0000-0002-1912-6020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d47c1f069594367b8f9169d673d1dba.json"}}, {"family": "Agrawal", "given": "Nishant", "initials": "N"}, {"family": "Dubovenko", "given": "Alexey", "initials": "A", "orcid": "0000-0002-8424-5106", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f6b0af89130473aaf4b162f743ac5a8.json"}}, {"family": "Vanhaelen", "given": "Quentin", "initials": "Q", "orcid": "0000-0002-4611-2046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e78a63ea937e424a9bc7a57023bdac7f.json"}}, {"family": "Ozerov", "given": "Ivan", "initials": "I"}, {"family": "Aliper", "given": "Alex", "initials": "A", "orcid": "0000-0002-4363-0710", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4057aed986b9489b995e45a29d47eece.json"}}, {"family": "Izumchenko", "given": "Evgeny", "initials": "E"}, {"family": "Zhavoronkov", "given": "Alex", "initials": "A", "orcid": "0000-0001-7067-8966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb35e56edd4345f3be5cc72840aaa355.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "PLoS Comput Biol", "issn": "1553-7358", "issn-l": null, "volume": "17", "issue": "7", "pages": "e1009183"}, "abstract": "Coronavirus disease 2019 (COVID-19) is an acute infection of the respiratory tract that emerged in December 2019 in Wuhan, China. It was quickly established that both the symptoms and the disease severity may vary from one case to another and several strains of SARS-CoV-2 have been identified. To gain a better understanding of the wide variety of SARS-CoV-2 strains and their associated symptoms, thousands of SARS-CoV-2 genomes have been sequenced in dozens of countries. In this article, we introduce COVIDomic, a multi-omics online platform designed to facilitate the analysis and interpretation of the large amount of health data collected from patients with COVID-19. The COVIDomic platform provides a comprehensive set of bioinformatic tools for the multi-modal metatranscriptomic data analysis of COVID-19 patients to determine the origin of the coronavirus strain and the expected severity of the disease. An integrative analytical workflow, which includes microbial pathogens community analysis, COVID-19 genetic epidemiology and patient stratification, allows to analyze the presence of the most common microbial organisms, their antibiotic resistance, the severity of the infection and the set of the most probable geographical locations from which the studied strain could have originated. The online platform integrates a user friendly interface which allows easy visualization of the results. We envision this tool will not only have immediate implications for management of the ongoing COVID-19 pandemic, but will also improve our readiness to respond to other infectious outbreaks.", "doi": "10.1371/journal.pcbi.1009183", "pmid": "34260589", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8312936"}, {"db": "pii", "key": "PCOMPBIOL-D-21-00029"}], "notes": [], "created": "2021-08-06T07:21:00.826Z", "modified": "2023-06-19T07:30:59.263Z"}, {"entity": "publication", "iuid": "b4b16c88742546d48699006bd1d5fc0b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b4b16c88742546d48699006bd1d5fc0b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b4b16c88742546d48699006bd1d5fc0b"}}, "title": "COVID-19: Symptoms in Dying Residents of Nursing Homes and in Those Admitted to Hospitals.", "authors": [{"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "Martinsson", "given": "Lisa", "initials": "L"}, {"family": "Bergstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Staffan", "initials": "S"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "J Palliat Med", "issn": "1557-7740", "volume": "24", "issue": "7", "pages": "1067-1071", "issn-l": null}, "abstract": "To compare symptom prevalence and relief in residents who died in nursing homes with residents who were acutely referred to hospitals. Objective: Data on symptoms during the last week of life from the Swedish Register of Palliative Care (SRPC). Design: Nursing homes (Setting and Subjects:n = 1903 deaths) and hospitals in Sweden (n = 202 nursing home residents who were admitted to hospital before death). Data were retrieved on August 24, 2020. Residents who died in hospitals had more breakthrough symptoms of breathlessness (60% vs. 31%, Results:p < 0.0001) and delirium (41% vs. 25%, p < 0.0001) than those who died in nursing homes. When symptoms were present, complete symptom relief was seen less often in hospitals compared with nursing homes (breathlessness, 28% vs. 47%, p < 0.001; delirium, 10% vs. 35%, p < 0.0001; respiratory secretions, 30% vs. 55%, p < 0.0001). Despite access to oxygen and pharmacologic/nonpharmacologic therapies in hospitals, symptom relief in dying nursing home residents acutely admitted to hospitals was lower compared with those who died in nursing homes, possibly because of differences in patient characteristics.Conclusion:", "doi": "10.1089/jpm.2020.0688", "pmid": "33667124", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-06T10:08:49.786Z", "modified": "2021-11-18T12:46:26.602Z"}, {"entity": "publication", "iuid": "861353a5c9474b8e9a227a18527a8b24", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/861353a5c9474b8e9a227a18527a8b24.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/861353a5c9474b8e9a227a18527a8b24"}}, "title": "An outbreak caused by the SARS-CoV-2 Delta variant (B.1.617.2) in a secondary care hospital in Finland, May 2021.", "authors": [{"family": "Hetem\u00e4ki", "given": "Iivo", "initials": "I"}, {"family": "K\u00e4\u00e4ri\u00e4inen", "given": "Sohvi", "initials": "S"}, {"family": "Alho", "given": "Pirjo", "initials": "P"}, {"family": "Mikkola", "given": "Janne", "initials": "J"}, {"family": "Savolainen-Kopra", "given": "Carita", "initials": "C"}, {"family": "Ikonen", "given": "Niina", "initials": "N"}, {"family": "Nohynek", "given": "Hanna", "initials": "H"}, {"family": "Lyytik\u00e4inen", "given": "Outi", "initials": "O"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "30", "issn-l": null}, "abstract": "An outbreak caused by the SARS-CoV-2 Delta variant (B.1.617.2) spread from one inpatient in a secondary care hospital to three primary care facilities, resulting in 58 infections including 18 deaths in patients and 45 infections in healthcare workers (HCW). Only one of the deceased cases was fully vaccinated. Transmission occurred despite the use of personal protective equipment by the HCW, as advised in national guidelines, and a high two-dose COVID-19 vaccination coverage among permanent staff members in the COVID-19 cohort ward.", "doi": "10.2807/1560-7917.ES.2021.26.30.2100636", "pmid": "34328076", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-04T17:04:15.593Z", "modified": "2021-08-04T17:04:15.606Z"}, {"entity": "publication", "iuid": "075dd5d3c80e4e08889468b3e65d1264", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/075dd5d3c80e4e08889468b3e65d1264.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/075dd5d3c80e4e08889468b3e65d1264"}}, "title": "Acute pulmonary hypertension and short-term outcomes in severe Covid-19 patients needing intensive care.", "authors": [{"family": "Norderfeldt", "given": "Joakim", "initials": "J"}, {"family": "Liliequist", "given": "Andreas", "initials": "A"}, {"family": "Frostell", "given": "Claes", "initials": "C", "orcid": "0000-0002-7199-1310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874beab519f143db8659a7936aa46142.json"}}, {"family": "Adding", "given": "Christofer", "initials": "C"}, {"family": "Agvald", "given": "Per", "initials": "P"}, {"family": "Eriksson", "given": "Maria", "initials": "M"}, {"family": "L\u00f6nnqvist", "given": "Per-Arne", "initials": "PA", "orcid": "0000-0002-8586-1429", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c49ad645c3064040b0b4f225529e9237.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": "65", "issue": "6", "pages": "761-769"}, "abstract": "Critically ill Covid-19 pneumonia patients are likely to develop the sequence of acute pulmonary hypertension, right ventricular (RV) strain, and eventually RV failure due to known pathophysiology (endothelial inflammation plus thrombo-embolism) that promotes increased pulmonary vascular resistance and pulmonary artery pressure. This study aimed to investigate the occurrence of acute pulmonary hypertension (aPH) as per established trans-thoracic echocardiography (TTE) criteria in Covid-19 patients receiving intensive care and to explore whether short-term outcomes are affected by the presence of aPH.\n\nMedical records were reviewed for patients treated in the intensive care units at a tertiary university hospital over a month. The presence of aPH on the TTE was noted, and plasma NTproBNP and troponin were measured as markers of cardiac failure and myocardial injury, respectively. Follow-up data were collected 21 d after the performance of TTE.\n\nIn total, 26 of 67 patients (39%) had an assessed systolic pulmonary artery pressure of > 35 mmHg (group aPH), meeting the TTE definition of aPH. NTproBNP levels (median [range]: 1430 [102-30 300] vs. 470 [45-29 600] ng L-1 ; P = .0007), troponin T levels (63 [22-352] vs. 15 [5-407] ng L-1 ; P = .0002), and the 21-d mortality rate (46% vs. 7%; P < .001) were substantially higher in patients with aPH compared to patients not meeting aPH criteria.\n\nTTE-defined acute pulmonary hypertension was frequently observed in severely ill Covid-19 patients. Furthermore, aPH was linked to biomarker-defined myocardial injury and cardiac failure, as well as an almost sevenfold increase in 21-d mortality.", "doi": "10.1111/aas.13819", "pmid": "33728633", "labels": {"Category: Health": null, "Type: Journal article": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC8250592"}], "notes": [], "created": "2021-03-22T11:31:19.318Z", "modified": "2021-11-18T13:18:45.397Z"}, {"entity": "publication", "iuid": "256bb4b8a56d4afca0d477c714ea20de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/256bb4b8a56d4afca0d477c714ea20de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/256bb4b8a56d4afca0d477c714ea20de"}}, "title": "A call for standardised age-disaggregated health data.", "authors": [{"family": "Diaz", "given": "Theresa", "initials": "T"}, {"family": "Strong", "given": "Kathleen L", "initials": "KL"}, {"family": "Cao", "given": "Bochen", "initials": "B"}, {"family": "Guthold", "given": "Regina", "initials": "R"}, {"family": "Moran", "given": "Allisyn C", "initials": "AC"}, {"family": "Moller", "given": "Ann-Beth", "initials": "AB"}, {"family": "Requejo", "given": "Jennifer", "initials": "J"}, {"family": "Sadana", "given": "Ritu", "initials": "R"}, {"family": "Thiyagarajan", "given": "Jotheeswaran Amuthavalli", "initials": "JA"}, {"family": "Adebayo", "given": "Emmanuel", "initials": "E"}, {"family": "Akwara", "given": "Elsie", "initials": "E"}, {"family": "Amouzou", "given": "Agbessi", "initials": "A"}, {"family": "Aponte Varon", "given": "John J", "initials": "JJ"}, {"family": "Azzopardi", "given": "Peter S", "initials": "PS"}, {"family": "Boschi-Pinto", "given": "Cynthia", "initials": "C"}, {"family": "Carvajal", "given": "Liliana", "initials": "L"}, {"family": "Chandra-Mouli", "given": "Venkatraman", "initials": "V"}, {"family": "Crofts", "given": "Sarah", "initials": "S"}, {"family": "Dastgiri", "given": "Saeed", "initials": "S"}, {"family": "Dery", "given": "Jeremiah S", "initials": "JS"}, {"family": "Elnakib", "given": "Shatha", "initials": "S"}, {"family": "Fagan", "given": "Laura", "initials": "L"}, {"family": "Jane Ferguson", "given": "B", "initials": "B"}, {"family": "Fitzner", "given": "Julia", "initials": "J"}, {"family": "Friedman", "given": "Howard S", "initials": "HS"}, {"family": "Hagell", "given": "Ann", "initials": "A"}, {"family": "Jongstra", "given": "Eduard", "initials": "E"}, {"family": "Kann", "given": "Laura", "initials": "L"}, {"family": "Chatterji", "given": "Somnath", "initials": "S"}, {"family": "English", "given": "Mike", "initials": "M"}, {"family": "Glaziou", "given": "Philippe", "initials": "P"}, {"family": "Hanson", "given": "Claudia", "initials": "C"}, {"family": "Hosseinpoor", "given": "Ahmad R", "initials": "AR"}, {"family": "Marsh", "given": "Andrew", "initials": "A"}, {"family": "Morgan", "given": "Alison P", "initials": "AP"}, {"family": "Munos", "given": "Melinda K", "initials": "MK"}, {"family": "Noor", "given": "Abdisalan", "initials": "A"}, {"family": "Pavlin", "given": "Boris I", "initials": "BI"}, {"family": "Pereira", "given": "Rich", "initials": "R"}, {"family": "Porth", "given": "Tyler A", "initials": "TA"}, {"family": "Schellenberg", "given": "Joanna", "initials": "J"}, {"family": "Siddique", "given": "Rizwana", "initials": "R"}, {"family": "You", "given": "Danzhen", "initials": "D"}, {"family": "Vaz", "given": "Lara M E", "initials": "LME"}, {"family": "Banerjee", "given": "Anshu", "initials": "A"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Lancet Healthy Longev", "issn": "2666-7568", "volume": "2", "issue": "7", "pages": "e436-e443", "issn-l": null}, "abstract": "The 2030 Sustainable Development Goals agenda calls for health data to be disaggregated by age. However, age groupings used to record and report health data vary greatly, hindering the harmonisation, comparability, and usefulness of these data, within and across countries. This variability has become especially evident during the COVID-19 pandemic, when there was an urgent need for rapid cross-country analyses of epidemiological patterns by age to direct public health action, but such analyses were limited by the lack of standard age categories. In this Personal View, we propose a recommended set of age groupings to address this issue. These groupings are informed by age-specific patterns of morbidity, mortality, and health risks, and by opportunities for prevention and disease intervention. We recommend age groupings of 5 years for all health data, except for those younger than 5 years, during which time there are rapid biological and physiological changes that justify a finer disaggregation. Although the focus of this Personal View is on the standardisation of the analysis and display of age groups, we also outline the challenges faced in collecting data on exact age, especially for health facilities and surveillance data. The proposed age disaggregation should facilitate targeted, age-specific policies and actions for health care and disease management.", "doi": "10.1016/S2666-7568(21)00115-X", "pmid": "34240065", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2666-7568(21)00115-X"}, {"db": "pmc", "key": "PMC8245325"}], "notes": [], "created": "2021-08-06T07:59:40.130Z", "modified": "2021-08-06T07:59:49.181Z"}, {"entity": "publication", "iuid": "cacc1bbd7796404bbf4f3a9b24e217fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cacc1bbd7796404bbf4f3a9b24e217fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cacc1bbd7796404bbf4f3a9b24e217fd"}}, "title": "Up State of the SARS-COV-2 Spike Homotrimer Favors an Increased Virulence for New Variants.", "authors": [{"family": "Giron", "given": "Carolina Corr\u00eaa", "initials": "CC"}, {"family": "Laaksonen", "given": "Aatto", "initials": "A"}, {"family": "Barroso da Silva", "given": "Fernando Lu\u00eds", "initials": "FL"}], "type": "journal article", "published": "2021-06-30", "journal": {"title": "Front Med Technol", "issn": "2673-3129", "issn-l": null, "volume": "3", "issue": null, "pages": "694347"}, "abstract": "The COVID-19 pandemic has spread worldwide. However, as soon as the first vaccines-the only scientifically verified and efficient therapeutic option thus far-were released, mutations combined into variants of SARS-CoV-2 that are more transmissible and virulent emerged, raising doubts about their efficiency. This study aims to explain possible molecular mechanisms responsible for the increased transmissibility and the increased rate of hospitalizations related to the new variants. A combination of theoretical methods was employed. Constant-pH Monte Carlo simulations were carried out to quantify the stability of several spike trimeric structures at different conformational states and the free energy of interactions between the receptor-binding domain (RBD) and angiotensin-converting enzyme II (ACE2) for the most worrying variants. Electrostatic epitopes were mapped using the PROCEEDpKa method. These analyses showed that the increased virulence is more likely to be due to the improved stability to the S trimer in the opened state, in which the virus can interact with the cellular receptor, ACE2, rather than due to alterations in the complexation RBD-ACE2, since the difference observed in the free energy values was small (although more attractive in general). Conversely, the South African/Beta variant (B.1.351), compared with the SARS-CoV-2 wild type (wt), is much more stable in the opened state with one or two RBDs in the up position than in the closed state with three RBDs in the down position favoring the infection. Such results contribute to understanding the natural history of disease and indicate possible strategies for developing new therapeutic molecules and adjusting the vaccine doses for higher B-cell antibody production.", "doi": "10.3389/fmedt.2021.694347", "pmid": "35047936", "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8757851"}], "notes": [], "created": "2022-01-27T07:01:54.014Z", "modified": "2022-01-27T07:03:25.405Z"}, {"entity": "publication", "iuid": "6f864b2f4ae5498b87b581187353d13f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f864b2f4ae5498b87b581187353d13f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f864b2f4ae5498b87b581187353d13f"}}, "title": "The concerns of oncology professionals during the COVID-19 pandemic: results from the ESMO Resilience Task Force survey II.", "authors": [{"family": "Lim", "given": "K H J", "initials": "KHJ"}, {"family": "Murali", "given": "K", "initials": "K"}, {"family": "Kamposioras", "given": "K", "initials": "K"}, {"family": "Punie", "given": "K", "initials": "K"}, {"family": "Oing", "given": "C", "initials": "C"}, {"family": "O'Connor", "given": "M", "initials": "M"}, {"family": "Thorne", "given": "E", "initials": "E"}, {"family": "Amaral", "given": "T", "initials": "T"}, {"family": "Garrido", "given": "P", "initials": "P"}, {"family": "Lambertini", "given": "M", "initials": "M"}, {"family": "Devnani", "given": "B", "initials": "B"}, {"family": "Westphalen", "given": "C B", "initials": "CB"}, {"family": "Morgan", "given": "G", "initials": "G"}, {"family": "Haanen", "given": "J B A G", "initials": "JBAG"}, {"family": "Hardy", "given": "C", "initials": "C"}, {"family": "Banerjee", "given": "S", "initials": "S"}], "type": "journal article", "published": "2021-06-30", "journal": {"title": "ESMO Open", "issn": "2059-7029", "volume": "6", "issue": "4", "pages": "100199", "issn-l": null}, "abstract": "The COVID-19 pandemic has resulted in significant changes to professional and personal lives of oncology professionals globally. The European Society for Medical Oncology (ESMO) Resilience Task Force collaboration aimed to provide contemporaneous reports on the impact of COVID-19 on the lived experiences and well-being in oncology.\n\nThis online anonymous survey (July-August 2020) is the second of a series of global surveys launched during the course of the pandemic. Longitudinal key outcome measures including well-being/distress (expanded Well-being Index-9 items), burnout (1 item from expanded Well-being Index), and job performance since COVID-19 were tracked.\n\nA total of 942 participants from 99 countries were included for final analysis: 58% (n = 544) from Europe, 52% (n = 485) female, 43% (n = 409) \u226440 years old, and 36% (n = 343) of non-white ethnicity. In July/August 2020, 60% (n = 525) continued to report a change in professional duties compared with the pre-COVID-19 era. The proportion of participants at risk of poor well-being (33%, n = 310) and who reported feeling burnout (49%, n = 460) had increased significantly compared with April/May 2020 (25% and 38%, respectively; P < 0.001), despite improved job performance since COVID-19 (34% versus 51%; P < 0.001). Of those who had been tested for COVID-19, 8% (n = 39/484) tested positive; 18% (n = 7/39) felt they had not been given adequate time to recover before return to work. Since the pandemic, 39% (n = 353/908) had expressed concerns that COVID-19 would have a negative impact on their career development or training and 40% (n = 366/917) felt that their job security had been compromised. More than two-thirds (n = 608/879) revealed that COVID-19 has changed their outlook on their work-personal life balance.\n\nThe COVID-19 pandemic continues to impact the well-being of oncology professionals globally, with significantly more in distress and feeling burnout compared with the first wave. Collective efforts from both national and international communities addressing support and coping strategies will be crucial as we recover from the COVID-19 crisis. In particular, an action plan should also be devised to tackle concerns raised regarding the negative impact of COVID-19 on career development, training, and job security.", "doi": "10.1016/j.esmoop.2021.100199", "pmid": "34217129", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2059-7029(21)00160-5"}], "notes": [], "created": "2021-07-05T15:03:06.220Z", "modified": "2021-07-05T15:03:54.367Z"}, {"entity": "publication", "iuid": "9be4d53064af40d2b097b15b815355dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9be4d53064af40d2b097b15b815355dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9be4d53064af40d2b097b15b815355dd"}}, "title": "Summary of European guidelines on infection control and prevention during COVID-19 pandemic.", "authors": [{"family": "Becker", "given": "Kathrin", "initials": "K", "orcid": "0000-0003-1936-4683", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cfa273f3515e470c87ad24540f6398f0.json"}}, {"family": "Gurzawska-Comis", "given": "Katarzyna", "initials": "K", "orcid": "0000-0002-3424-5968", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2b36d90d1804c67aa844537ce625fe7.json"}}, {"family": "Brunello", "given": "Giulia", "initials": "G", "orcid": "0000-0003-1436-0085", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c41e6e7b6a6d4070ba5e61aec8e085ad.json"}}, {"family": "Klinge", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0003-2100-2446", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b0a71c3b5b93430c817278f62204b5db.json"}}], "type": "journal article", "published": "2021-06-30", "journal": {"title": "Clin Oral Implants Res", "issn": "1600-0501", "issn-l": null}, "abstract": "The current COVID-19 pandemic highlighted the need for a review of guidelines on infection control and prevention to ensure safe delivery of dental care. However, it is not clear to what extent the rapidly published European guidelines reflect the current evidence and thus provide homogeneous recommendations.\n\nGuidelines from all European Union countries, Scotland, Switzerland and United Kingdom were retrieved. Information on triage, mouth rinse, personal protective equipment (PPE) for aerosol free/ generating procedures (non-AGP/AGP) and treatment of potentially infectious patients were summarised, and compared with recommendations from international organizations (WHO, ECDC, CDC).\n\nAll included countries (30/30) published COVID-19 guidelines in 2020. All countries recommended triage and to postpone non-urgent treatment of potentially infectious patients. Hydrogen peroxide (1-1.5%) was the most frequently recommended antiseptic mouth rinse to reduce viral load (24/30). PPE for non-AGP treatments included mainly surgical masks (21/30) or FFP2/FFP3/N95 masks (16/30), whereas FFP2/FFP3 masks (25/30) and face shields (24/30) were recommended for AGP by the vast majority of guidelines. For high-risk/COVID positive patients, most countries recommended maximum protection, and treatment in specialised dental clinics (22/30).\n\nThere was general agreement among recommendations for triage, mouth rinse, and PPE during AGP and treatment of potentially infectious patients. In contrast, recommendations on PPE for non-AGP treatment varied considerably among the European countries possibly due to limited scientific evidence regarding transmission risk during non-AGP treatments.", "doi": "10.1111/clr.13784", "pmid": "34196047", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-07-05T14:31:00.569Z", "modified": "2021-07-05T14:31:00.690Z"}, {"entity": "publication", "iuid": "d37e5e75fe864447a97b9b63be6cab54", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d37e5e75fe864447a97b9b63be6cab54.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d37e5e75fe864447a97b9b63be6cab54"}}, "title": "ReCOV: recovery and rehabilitation during and after COVID-19 - a study protocol of a longitudinal observational study on patients, next of kin and health care staff.", "authors": [{"family": "Rydwik", "given": "E", "initials": "E", "orcid": "0000-0003-0550-1675", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03e46fbd5a7547ecb1f98245d30f3586.json"}}, {"family": "Anmyr", "given": "L", "initials": "L"}, {"family": "Regardt", "given": "M", "initials": "M"}, {"family": "McAllister", "given": "A", "initials": "A"}, {"family": "Zarenoe", "given": "R", "initials": "R"}, {"family": "\u00c5kerman", "given": "E", "initials": "E"}, {"family": "Orrevall", "given": "Y", "initials": "Y"}, {"family": "Bragesj\u00f6", "given": "M", "initials": "M"}, {"family": "Dahl", "given": "O", "initials": "O"}, {"family": "Kemani", "given": "M K", "initials": "MK"}, {"family": "Nordstrand", "given": "L", "initials": "L"}, {"family": "Ekman", "given": "U", "initials": "U"}, {"family": "Holmstr\u00f6m", "given": "L", "initials": "L"}, {"family": "Nygren-Bonnier", "given": "M", "initials": "M"}], "type": "journal article", "published": "2021-06-30", "journal": {"title": "BMC Sports Sci Med Rehabil", "issn": "2052-1847", "issn-l": null, "volume": "13", "issue": "1", "pages": "70"}, "abstract": "The knowledge of the long-term consequences of covid-19 is limited. In patients, symptoms such as fatigue, decreased physical, psychological, and cognitive function, and nutritional problems have been reported. How the disease has affected next of kin, as well as staff involved in the care of patients with covid-19, is also largely unknown. The overall aim of this study is therefore three-fold: (1) to describe and evaluate predictors of patient recovery, the type of rehabilitation received and patients' experiences of specialized rehabilitation following COVID-19 infection; (2) to study how next of kin experienced the hospital care of their relative and their experiences of the psychosocial support they received as well as their psychological wellbeing; (3) to describe experiences of caring for patients with COVID-19 and evaluate psychological wellbeing, coping mechanisms and predictors for development of psychological distress over time in health care staff.\n\nThis observational longitudinal study consists of three cohorts; patients, next of kin, and health care staff. The assessments for the patients consist of physical tests (lung function, muscle strength, physical capacity) and questionnaires (communication and swallowing, nutritional status, hearing, activities of daily living, physical activity, fatigue, cognition) longitudinally at 3, 6 and 12 months. Patient records auditing (care, rehabilitation) will be done retrospectively at 12 months. Patients (3, 6 and 12 months), next of kin (6 months) and health care staff (baseline, 3, 6, 9 and 12 months) will receive questionnaires regarding, health-related quality of life, depression, anxiety, sleeping disorders, and post-traumatic stress. Staff will also answer questionnaires about burnout and coping strategies. Interviews will be conducted in all three cohorts.\n\nThis study will be able to answer different research questions from a quantitative and qualitative perspective, by describing and evaluating long-term consequences and their associations with recovery, as well as exploring patients', next of kins' and staffs' views and experiences of the disease and its consequences. This will form a base for a deeper and better understanding of the consequences of the disease from different perspectives as well as helping the society to better prepare for a future pandemic.", "doi": "10.1186/s13102-021-00299-9", "pmid": "34193260", "labels": {"Category: Public Health": null, "Type: Journal article": null, "Category: Rehabilitation": null}, "xrefs": [{"db": "pmc", "key": "PMC8243048"}, {"db": "pii", "key": "10.1186/s13102-021-00299-9"}], "notes": [], "created": "2021-07-05T14:28:53.739Z", "modified": "2023-06-19T15:22:19.071Z"}, {"entity": "publication", "iuid": "67ce74a43c114f79ad88ccc156f49658", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/67ce74a43c114f79ad88ccc156f49658.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/67ce74a43c114f79ad88ccc156f49658"}}, "title": "Investigation of Four Clusters of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Rwanda, 2020.", "authors": [{"family": "Nsekuye", "given": "Olivier", "initials": "O"}, {"family": "Rwagasore", "given": "Edson", "initials": "E"}, {"family": "Muhimpundu", "given": "Marie Aime", "initials": "MA"}, {"family": "El-Khatib", "given": "Ziad", "initials": "Z", "orcid": "0000-0003-0756-7280", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31747e0476314de9bf53d8c8f3d1d147.json"}}, {"family": "Ntabanganyimana", "given": "Daniel", "initials": "D", "orcid": "0000-0003-2183-7873", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c49ec8a0b5e4c1e97744c1540826453.json"}}, {"family": "Kamayirese", "given": "Eric No\u00ebl", "initials": "EN"}, {"family": "Ruyange", "given": "Laurent", "initials": "L"}, {"family": "Umutoni", "given": "Angela", "initials": "A"}, {"family": "Adeline", "given": "Adeline Kabeja", "initials": "AK"}, {"family": "Ntaganira", "given": "Joseph", "initials": "J"}, {"family": "Nsazimana", "given": "Sabin", "initials": "S"}, {"family": "Omolo", "given": "Jared", "initials": "J"}], "type": "journal article", "published": "2021-06-30", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "13", "pages": "7018"}, "abstract": "We reported the findings of the first Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) four clusters identified in Rwanda. Case-investigations included contact elicitation, testing, and isolation/quarantine of confirmed cases. Socio-demographic and clinical data on cases and contacts were collected. A confirmed case was a person with laboratory confirmation of SARS-CoV-2 infection (PCR) while a contact was any person who had contact with a SARS-CoV-2 confirmed case within 72 h prior, to 14 days after symptom onset; or 14 days before collection of the laboratory-positive sample for asymptomatic cases. High risk contacts were those who had come into unprotected face-to-face contact or had been in a closed environment with a SARS-CoV-2 case for >15 min. Forty cases were reported from four clusters by 22 April 2020, accounting for 61% of locally transmitted cases within six weeks. Clusters A, B, C and D were associated with two nightclubs, one house party, and different families or households living in the same compound (multi-family dwelling). Thirty-six of the 1035 contacts tested were positive (secondary attack rate: 3.5%). Positivity rates were highest among the high-risk contacts compared to low-risk contacts (10% vs. 2.2%). Index cases in three of the clusters were imported through international travelling. Fifteen of the 40 cases (38%) were asymptomatic while 13/25 (52%) and 8/25 (32%) of symptomatic cases had a cough and fever respectively. Gatherings in closed spaces were the main early drivers of transmission. Systematic case-investigations contact tracing and testing likely contributed to the early containment of SARS-CoV-2 in Rwanda.", "doi": "10.3390/ijerph18137018", "pmid": "34209123", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8297211"}, {"db": "pii", "key": "ijerph18137018"}], "notes": [], "created": "2021-07-05T14:56:56.299Z", "modified": "2023-06-19T15:17:29.655Z"}, {"entity": "publication", "iuid": "ef958c3e559b4e04ba017e6252046903", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef958c3e559b4e04ba017e6252046903.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef958c3e559b4e04ba017e6252046903"}}, "title": "Dental care during COVID-19 pandemic: follow-up survey of experts' opinion.", "authors": [{"family": "Brunello", "given": "Giulia", "initials": "G", "orcid": "0000-0003-1436-0085", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c41e6e7b6a6d4070ba5e61aec8e085ad.json"}}, {"family": "Gurzawska-Comis", "given": "Katarzyna", "initials": "K"}, {"family": "Becker", "given": "Kathrin", "initials": "K", "orcid": "0000-0003-1936-4683", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cfa273f3515e470c87ad24540f6398f0.json"}}, {"family": "Becker", "given": "J\u00fcrgen", "initials": "J"}, {"family": "Sivolella", "given": "Stefano", "initials": "S", "orcid": "0000-0003-1916-1640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9d22e893e164fb2958aeff923b6fad5.json"}}, {"family": "Schwarz", "given": "Frank", "initials": "F", "orcid": "0000-0001-5515-227X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5c1fcc3c85944960a9b564494441473d.json"}}, {"family": "Klinge", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2021-06-30", "journal": {"title": "Clin Oral Implants Res", "issn": "1600-0501", "issn-l": null}, "abstract": "The purpose of the present survey is to give an update of European experts' opinion on infection control and prevention in dentistry during second wave of pandemic. The secondary aim was to analyse how experts' opinion changed in the light of the new scientific evidence since the first wave.\n\nAn anonymous online 14-item questionnaire was sent to a total of 27 leading academic experts in Oral (and Maxillofacial) Surgery from different European countries, who had completed a previous survey in April-May 2020. The questionnaire covered the topics of dental setting safety, personal protective equipment (PPE), and patient-related measures to minimise transmission risk. Data collection took place in November-February 2020/21.\n\n26 experts participated in the follow-up survey. The overall transmission risk in dental settings was scored significantly lower compared to the initial survey (P<0.05), though the risk associated with aerosol generating procedures (AGP) was still considered to be high. Maximum PPE was less frequently recommended for non-AGP (P<0.05), whereas the majority of experts still recommended FFP2/FFP3 masks (80.8%), face shields or goggles (88.5%), gowns (61.5%), and caps (57.7%) for AGP. Most of the experts also found mouth rinse relevant (73.1%) and reported to be using it prior to treatment (76.9%). No uniform opinion was found regarding the relevance of COVID-19 testing of staff and patients.\n\nWith the continuation of dental care provision, transmission risk has been scored lower compared to the first wave of pandemic. However, high risk is still assumed for AGP, and maximum PPE remained advised for the respective treatments.", "doi": "10.1111/clr.13783", "pmid": "34196051", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-07-05T14:31:22.874Z", "modified": "2021-07-05T14:31:22.956Z"}, {"entity": "publication", "iuid": "32a80056c0f2441cbd9e3bc51494ca52", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/32a80056c0f2441cbd9e3bc51494ca52.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/32a80056c0f2441cbd9e3bc51494ca52"}}, "title": "Civic Duty: A Booster for Resilience?", "authors": [{"family": "Grimm", "given": "Pauline Yongeun", "initials": "PY"}, {"family": "Saulnier", "given": "Dell D", "initials": "DD"}], "type": "editorial", "published": "2021-06-30", "journal": {"title": "Int J Public Health", "issn": "1661-8564", "volume": "66", "pages": "1604064", "issn-l": null}, "abstract": null, "doi": "10.3389/ijph.2021.1604064", "pmid": "34335149", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "1604064"}, {"db": "pmc", "key": "PMC8284586"}], "notes": [], "created": "2021-08-04T10:13:00.336Z", "modified": "2021-08-04T10:13:00.358Z"}, {"entity": "publication", "iuid": "cde11c2a5b9d4d04b30c791570e1a5f3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cde11c2a5b9d4d04b30c791570e1a5f3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cde11c2a5b9d4d04b30c791570e1a5f3"}}, "title": "Widespread Parenchymal Abnormalities and Pulmonary Embolism on Contrast-Enhanced CT Predict Disease Severity and Mortality in Hospitalized COVID-19 Patients.", "authors": [{"family": "Jalde", "given": "Francesca Campoccia", "initials": "FC"}, {"family": "Beckman", "given": "Mats O", "initials": "MO"}, {"family": "Svensson", "given": "Ann Mari", "initials": "AM"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "Sk\u00f6ld", "given": "Magnus", "initials": "M"}, {"family": "Strand", "given": "Fredrik", "initials": "F"}, {"family": "Nyren", "given": "Sven", "initials": "S"}, {"family": "Kistner", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-06-29", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "8", "pages": "666723", "issn-l": null}, "abstract": "Purpose: Severe COVID-19 is associated with inflammation, thromboembolic disease, and high mortality. We studied factors associated with fatal outcomes in consecutive COVID-19 patients examined by computed tomography pulmonary angiogram (CTPA). Methods: This retrospective, single-center cohort analysis included 130 PCR-positive patients hospitalized for COVID-19 [35 women and 95 men, median age 57 years (interquartile range 51-64)] with suspected pulmonary embolism based on clinical suspicion. The presence and extent of embolism and parenchymal abnormalities on CTPA were recorded. The severity of pulmonary parenchymal involvement was stratified by two experienced radiologists into two groups: lesions affecting \u226450% or >50% of the parenchyma. Patient characteristics, radiological aspects, laboratory parameters, and 60-day mortality data were collected. Results: Pulmonary embolism was present in 26% of the patients. Most emboli were small and peripheral. Patients with widespread parenchymal abnormalities, with or without pulmonary embolism, had increased main pulmonary artery diameter (p < 0.05) and higher C-reactive protein (p < 0.01), D-dimer (p < 0.01), and troponin T (p < 0.001) and lower hemoglobin (p < 0.001). A wider main pulmonary artery diameter correlated positively with C-reactive protein (r = 0.28, p = 0.001, and n = 130) and procalcitonin. In a multivariant analysis, D-dimer >7.2 mg/L [odds ratio (\u00b195% confidence interval) 4.1 (1.4-12.0)] and ICU stay were significantly associated with embolism (p < 0.001). The highest 60-day mortality was found in patients with widespread parenchymal abnormalities combined with pulmonary embolism (36%), followed by patients with widespread parenchymal abnormalities without pulmonary embolism (26%). In multivariate analysis, high troponin T, D-dimer, and plasma creatinine and widespread parenchymal abnormalities on CT were associated with 60-day mortality. Conclusions: Pulmonary embolism combined with widespread parenchymal abnormalities contributed to mortality risk in COVID-19. Elevated C-reactive protein, D-dimer, troponin-T, P-creatinine, and enlarged pulmonary artery were associated with a worse outcome and may mirror a more severe systemic disease. A liberal approach to radiological investigation should be recommended at clinical deterioration, when the situation allows it. Computed tomography imaging, even without intravenous contrast to assess the severity of pulmonary infiltrates, are of value to predict outcome in COVID-19. Better radiological techniques with higher resolution could potentially improve the detection of microthromboses. This could influence anticoagulant treatment strategies, preventing clinical detoriation.", "doi": "10.3389/fmed.2021.666723", "pmid": "34268322", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8275973"}], "notes": [], "created": "2021-08-06T07:16:54.586Z", "modified": "2021-08-06T07:16:54.598Z"}, {"entity": "publication", "iuid": "578ea654c3144268b705f02fc41b589b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/578ea654c3144268b705f02fc41b589b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/578ea654c3144268b705f02fc41b589b"}}, "title": "The impact of the coronavirus (COVID-19) pandemic on individuals with gastrointestinal disorders: A protocol of an international collaborative study.", "authors": [{"family": "Ferreira", "given": "Nuno", "initials": "N"}, {"family": "Mikocka-Walus", "given": "Antonina", "initials": "A"}, {"family": "van Tilburg", "given": "Miranda A L", "initials": "MAL"}, {"family": "Graff", "given": "Lesley A", "initials": "LA"}, {"family": "Apputhurai", "given": "Pragalathan", "initials": "P"}, {"family": "Acosta", "given": "Manuel Barreiro-de", "initials": "MB"}, {"family": "Evertsz", "given": "Floor Bennebroek", "initials": "FB"}, {"family": "Burisch", "given": "Johan", "initials": "J"}, {"family": "Lo", "given": "Bobby", "initials": "B"}, {"family": "Petrik", "given": "Megan", "initials": "M"}, {"family": "Trindade", "given": "In\u00eas A", "initials": "IA"}, {"family": "Jedel", "given": "Sharon", "initials": "S"}, {"family": "Moser", "given": "Gabriele", "initials": "G"}, {"family": "Mokrowiecka", "given": "Anna", "initials": "A"}, {"family": "Bernstein", "given": "Charles N", "initials": "CN"}, {"family": "Dumitrascu", "given": "Dan", "initials": "D"}, {"family": "Ford", "given": "Alexander C", "initials": "AC"}, {"family": "Stengel", "given": "Andreas", "initials": "A"}, {"family": "Gearry", "given": "Richard", "initials": "R"}, {"family": "Knowles", "given": "Simon R", "initials": "SR"}], "type": "journal article", "published": "2021-06-29", "journal": {"title": "J Psychosom Res", "issn": "1879-1360", "volume": "148", "pages": "110561", "issn-l": null}, "abstract": "The COVID-19 pandemic has had a significant impact on mental health across the globe. People living with a chronic gastrointestinal (GI) disorder might be particularly at risk of mental health complications given higher rates of comorbid anxiety and depression compared to the healthy population. As GI disorders affect up to 40% of the population worldwide, this international collaborative study seeks to evaluate the extent of the impact of the COVID-19 pandemic on GI symptoms specifically and more generally on the well-being of those living with chronic GI conditions.\n\nA longitudinal survey with three time points (baseline, 6-month, and 12-month) will be conducted online. Adult participants with GI disorders from multiple countries will be recruited via patient associations, social media advertising, utilizing snowball sampling. Participants will be invited to complete a battery of questionnaires including demographic and health parameters, and measures of gastrointestinal symptoms, fear of COVID-19, perceived impact of COVID-19, illness perceptions, coping, depression, anxiety, stress, catastrophizing, and quality of life, using validated measures where available. Statistical analyses will include univariate descriptive models, multivariate models utilizing regression, mediation, and moderation, and latent growth models.\n\nThis project may present novel information to the field of psychogastroenterology and may provide crucial information regarding the areas of impact for individuals with GI disorders during and following the pandemic. Further, this information can guide healthcare providers and patient associations on how to target support related to the pandemic mental health sequelae for these patients.", "doi": "10.1016/j.jpsychores.2021.110561", "pmid": "34217956", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0022-3999(21)00206-3"}], "notes": [], "created": "2021-07-05T15:04:38.704Z", "modified": "2021-07-05T15:06:09.736Z"}, {"entity": "publication", "iuid": "a7060bc88a5641bcaafcfe88f603e514", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7060bc88a5641bcaafcfe88f603e514.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7060bc88a5641bcaafcfe88f603e514"}}, "title": "Seeing the value of experiential knowledge through COVID-19.", "authors": [{"family": "Atkinson", "given": "Sarah", "initials": "S", "orcid": "0000-0002-7186-0644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c24c1190d314847aec131249e583e59.json"}}, {"family": "Bradby", "given": "Hannah", "initials": "H", "orcid": "0000-0002-0664-1170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6650bd723f06404cb9f068d9bda13541.json"}}, {"family": "Gadebusch Bondio", "given": "Mariacarla", "initials": "M", "orcid": "0000-0002-5888-3059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53081b0715ff45b38f498a2fc8d3c09b.json"}}, {"family": "Hallberg", "given": "Anna", "initials": "A"}, {"family": "Macnaugthon", "given": "Jane", "initials": "J", "orcid": "0000-0002-7289-4037", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30fe568b9ecf480db633a8c576dad98d.json"}}, {"family": "S\u00f6derfeldt", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-6650-9710", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/193918c12f45489cb6cd8c949130e537.json"}}], "type": "journal article", "published": "2021-06-29", "journal": {"title": "Hist Philos Life Sci", "issn": "1742-6316", "volume": "43", "issue": "3", "pages": "85", "issn-l": null}, "abstract": "Seeing the entwinement of social and epistemic challenges through COVID, we discuss the perils of simplistic appeals to 'follow the science'. A hardened scientism risks excarbating social conflict and fueling conspiracy beliefs. Instead, we see an opportunity to devise more inclusive medical knowledge practices through endorsing experiential knowledge alongside traditional evidence types.", "doi": "10.1007/s40656-021-00438-y", "pmid": "34185187", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40656-021-00438-y"}], "notes": [], "created": "2021-06-30T04:58:23.052Z", "modified": "2021-06-30T04:58:23.181Z"}, {"entity": "publication", "iuid": "8c8581cfbe8541fc86599ac454263ffa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c8581cfbe8541fc86599ac454263ffa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c8581cfbe8541fc86599ac454263ffa"}}, "title": "Prevalence and incidence of anti-SARS-CoV-2 antibodies among healthcare workers in Belgian hospitals before vaccination: a prospective cohort study.", "authors": [{"family": "Mortgat", "given": "Laure", "initials": "L", "orcid": "0000-0002-8298-8547", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c830ab924e74a4285176040566ba96c.json"}}, {"family": "Verdonck", "given": "Kristien", "initials": "K", "orcid": "0000-0003-1153-4078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44033acf25e24dfb945b0c6300d2be4f.json"}}, {"family": "Hutse", "given": "Veronik", "initials": "V"}, {"family": "Thomas", "given": "Isabelle", "initials": "I"}, {"family": "Barbezange", "given": "Cyril", "initials": "C"}, {"family": "Heyndrickx", "given": "Leo", "initials": "L"}, {"family": "Fischer", "given": "Natalie", "initials": "N"}, {"family": "Vuylsteke", "given": "Bea", "initials": "B"}, {"family": "Kabouche", "given": "Ines", "initials": "I"}, {"family": "Ari\u00ebn", "given": "Kevin K", "initials": "KK"}, {"family": "Desombere", "given": "Isabelle", "initials": "I"}, {"family": "Duysburgh", "given": "Els", "initials": "E"}], "type": "journal article", "published": "2021-06-29", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "6", "pages": "e050824", "issn-l": "2044-6055"}, "abstract": "To describe prevalence and incidence of anti-SARS-CoV-2 antibodies among Belgian hospital healthcare workers (HCW) in April-December 2020.\n\nProspective cohort study. Follow-up was originally planned until September and later extended.\n\nMulticentre study, 17 hospitals.\n\n50 HCW were randomly selected per hospital. HCW employed beyond the end of the study and whose profession involved contact with patients were eligible. 850 HCW entered the study in April-May 2020, 673 HCW (79%) attended the September visit and 308 (36%) the December visit.\n\nA semiquantitative ELISA was used to detect IgG against SARS-CoV-2 in serum (Euroimmun) at 10 time points. In seropositive samples, neutralising antibodies were measured using a virus neutralisation test. Real-time reverse transcription PCR (RT-qPCR) was performed to detect SARS-CoV-2 on nasopharyngeal swabs. Participant characteristics and the presence of symptoms were collected via an online questionnaire.\n\nAmong all participants, 80% were women, 60% nurses and 21% physicians. Median age was 40 years. The seroprevalence remained relatively stable from April (7.7% (95% CI: 4.8% to 12.1%) to September (8.2% (95% CI: 5.7% to 11.6%)) and increased thereafter, reaching 19.7% (95% CI: 12.0% to 30.6%) in December 2020. 76 of 778 initially seronegative participants seroconverted during the follow-up (incidence: 205/1000 person-years). Among all seropositive individuals, 118/148 (80%) had a positive neutralisation test, 83/147 (56%) presented or reported a positive RT-qPCR, and 130/147 (88%) reported COVID-19-compatible symptoms at least once. However, only 46/73 (63%) of the seroconverters presented COVID-19-compatible symptoms in the month prior to seroconversion.\n\nThe seroprevalence among hospital HCW was slightly higher than that of the general Belgian population but followed a similar evolution, suggesting that infection prevention and control measures were effective and should be strictly maintained. After two SARS-CoV-2 waves, 80% of HCW remained seronegative, justifying their prioritisation in the vaccination strategy.\n\nNCT04373889.", "doi": "10.1136/bmjopen-2021-050824", "pmid": "34187832", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-050824"}, {"db": "pmc", "key": "PMC8245288"}, {"db": "ClinicalTrials.gov", "key": "NCT04373889"}], "notes": [], "created": "2021-07-05T14:23:22.273Z", "modified": "2021-07-05T14:23:22.338Z"}, {"entity": "publication", "iuid": "9eb01593d4c547d7823b006e981ce6fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9eb01593d4c547d7823b006e981ce6fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9eb01593d4c547d7823b006e981ce6fc"}}, "title": "Combined Metabolic Activators Accelerates Recovery in Mild\u2010to\u2010Moderate COVID\u201019", "authors": [{"family": "Altay", "given": "Ozlem", "initials": "O"}, {"family": "Arif", "given": "Muhammad", "initials": "M"}, {"family": "Li", "given": "Xiangyu", "initials": "X"}, {"family": "Yang", "given": "Hong", "initials": "H"}, {"family": "Ayd\u0131n", "given": "Mehtap", "initials": "M"}, {"family": "Alkurt", "given": "Gizem", "initials": "G"}, {"family": "Kim", "given": "Woonghee", "initials": "W"}, {"family": "Akyol", "given": "Dogukan", "initials": "D"}, {"family": "Zhang", "given": "Cheng", "initials": "C"}, {"family": "Dinler\u2010Doganay", "given": "Gizem", "initials": "G"}, {"family": "Turkez", "given": "Hasan", "initials": "H"}, {"family": "Shoaie", "given": "Saeed", "initials": "S"}, {"family": "Nielsen", "given": "Jens", "initials": "J"}, {"family": "Bor\u00e9n", "given": "Jan", "initials": "J"}, {"family": "Olmuscelik", "given": "Oktay", "initials": "O"}, {"family": "Doganay", "given": "Levent", "initials": "L"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A"}], "type": "journal-article", "published": "2021-06-28", "journal": {"title": "Adv. Sci.", "issn": "2198-3844", "issn-l": null, "volume": null, "issue": null, "pages": "2101222"}, "abstract": null, "doi": "10.1002/advs.202101222", "pmid": null, "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.1002/advs.202101222", "description": "Raw, patient-level characteristics and data"}], "notes": [], "created": "2021-06-28T18:03:41.425Z", "modified": "2021-07-06T09:30:30.964Z"}, {"entity": "publication", "iuid": "886c0b7aa006483ebf152b73ed4aab93", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/886c0b7aa006483ebf152b73ed4aab93.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/886c0b7aa006483ebf152b73ed4aab93"}}, "title": "Case Report: Systemic Sclerosis After Covid-19 Infection.", "authors": [{"family": "Fineschi", "given": "Serena", "initials": "S"}], "type": "case reports", "published": "2021-06-28", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "12", "pages": "686699", "issn-l": "1664-3224"}, "abstract": "The coronavirus disease (COVID-19) is a respiratory tract infection caused by the new virus SARS-CoV-2. The acute phase of the infection may in certain individuals be followed by another longer phase of disease (long COVID) of unknown etiology probably associated in certain cases with autoimmune activation. It has been shown that COVID-19 can trigger autoantibody production and in genetically predisposed patients may cause the onset or exacerbation of autoimmune diseases. We are reporting a case of mild COVID-19 infection complicated by autoantibody production and cutaneous and gastrointestinal symptoms and subsequently diagnosed with systemic sclerosis (SSc). A 47-year-old man with no history of any autoimmune diseases and in good health became sick together with his family on the 12th of November with mild symptoms: tiredness, fever, cough, and sore throat. Oropharyngeal swab for SARS-CoV-2 tested positive. He was isolated at home and did not require hospitalization. Three weeks later he presented with clinical manifestation compatible with suspicion of SSc. He briefly presented with skin rush, periorbital edema and conjunctivitis, vomiting, dysphagia, burning sensation in the skin, above all in the fingertips and around the mouth, puffy fingers, Raynaud's phenomenon, pain at the fingertip of the middle finger where a depressed area was noticed without a clear ulceration. ANA showed a strongly positive nucleolar pattern. Anti-PM/Scl 75 and PM/Scl 100 resulted positive. High-resolution computed tomography (HCRT) showed early stage of interstitial lung disease (ILD). The patient was diagnosed with SSc based on the persistence of autoantibodies and the clinical and radiological pictures according to the ACR/EULAR classification (scores: puffy finger, 2; ILD, 2; Raynaud's phenomenon, 3; SSc related antibodies, 3; total 10). There are several cases described in the medical literature of possible new onset of SLE after COVID-19 infection. This is the first case that describes a possible new onset of SSc. Conclusion: SARS-CoV-2 may trigger systemic sclerosis.", "doi": "10.3389/fimmu.2021.686699", "pmid": "34262566", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8273695"}], "notes": [], "created": "2021-08-06T07:17:58.171Z", "modified": "2021-08-06T07:18:53.884Z"}, {"entity": "publication", "iuid": "fb6a3ca888ca4cedbbc1e13a3fed36be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb6a3ca888ca4cedbbc1e13a3fed36be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb6a3ca888ca4cedbbc1e13a3fed36be"}}, "title": "A review and agenda for integrated disease models including social and behavioural factors.", "authors": [{"family": "Bedson", "given": "Jamie", "initials": "J"}, {"family": "Skrip", "given": "Laura A", "initials": "LA"}, {"family": "Pedi", "given": "Danielle", "initials": "D"}, {"family": "Abramowitz", "given": "Sharon", "initials": "S", "orcid": "0000-0003-3671-8842", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6bd9191aa8464bb58424225e812d761c.json"}}, {"family": "Carter", "given": "Simone", "initials": "S", "orcid": "0000-0003-3818-3538", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/227e9d375a6649df95425a287f069f01.json"}}, {"family": "Jalloh", "given": "Mohamed F", "initials": "MF"}, {"family": "Funk", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-2842-3406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f03dcbc41884648a4eac5892852899a.json"}}, {"family": "Gobat", "given": "Nina", "initials": "N", "orcid": "0000-0002-1558-557X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78a857e67488494caced727f69c370cf.json"}}, {"family": "Giles-Vernick", "given": "Tamara", "initials": "T", "orcid": "0000-0003-2873-8544", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a47231b81c92440da0d4fdc91b79c108.json"}}, {"family": "Chowell", "given": "Gerardo", "initials": "G"}, {"family": "de Almeida", "given": "Jo\u00e3o Rangel", "initials": "JR", "orcid": "0000-0002-8533-7942", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e0727d3e3ab411987c0dee3120dd1e1.json"}}, {"family": "Elessawi", "given": "Rania", "initials": "R"}, {"family": "Scarpino", "given": "Samuel V", "initials": "SV"}, {"family": "Hammond", "given": "Ross A", "initials": "RA"}, {"family": "Briand", "given": "Sylvie", "initials": "S"}, {"family": "Epstein", "given": "Joshua M", "initials": "JM"}, {"family": "H\u00e9bert-Dufresne", "given": "Laurent", "initials": "L", "orcid": "0000-0002-0008-3673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d7de71d9cc94861a3e846ff6e2ec221.json"}}, {"family": "Althouse", "given": "Benjamin M", "initials": "BM", "orcid": "0000-0002-5464-654X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90d8ce24f2004d148411bb922f38c418.json"}}], "type": "journal article", "published": "2021-06-28", "journal": {"title": "Nat Hum Behav", "issn": "2397-3374", "issn-l": "2397-3374"}, "abstract": "Social and behavioural factors are critical to the emergence, spread and containment of human disease, and are key determinants of the course, duration and outcomes of disease outbreaks. Recent epidemics of Ebola in West Africa and coronavirus disease 2019 (COVID-19) globally have reinforced the importance of developing infectious disease models that better integrate social and behavioural dynamics and theories. Meanwhile, the growth in capacity, coordination and prioritization of social science research and of risk communication and community engagement (RCCE) practice within the current pandemic response provides an opportunity for collaboration among epidemiological modellers, social scientists and RCCE practitioners towards a mutually beneficial research and practice agenda. Here, we provide a review of the current modelling methodologies and describe the challenges and opportunities for integrating them with social science research and RCCE practice. Finally, we set out an agenda for advancing transdisciplinary collaboration for integrated disease modelling and for more robust policy and practice for reducing disease transmission.", "doi": "10.1038/s41562-021-01136-2", "pmid": "34183799", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41562-021-01136-2"}], "notes": [], "created": "2021-06-30T04:58:04.398Z", "modified": "2021-06-30T04:58:04.584Z"}, {"entity": "publication", "iuid": "c810a662405f412a878a8c0e624c3bfb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c810a662405f412a878a8c0e624c3bfb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c810a662405f412a878a8c0e624c3bfb"}}, "title": "Psychological Determinants of COVID-19 Vaccine Acceptance among Healthcare Workers in Kuwait: A Cross-Sectional Study Using the 5C and Vaccine Conspiracy Beliefs Scales.", "authors": [{"family": "Al-Sanafi", "given": "Mariam", "initials": "M"}, {"family": "Sallam", "given": "Malik", "initials": "M"}], "type": "journal article", "published": "2021-06-25", "journal": {"title": "Vaccines", "issn": "2076-393X", "issn-l": null, "volume": "9", "issue": "7", "pages": null}, "abstract": "Acceptance of coronavirus disease 2019 (COVID-19) vaccination appears as a decisive factor necessary to control the ongoing pandemic. Healthcare workers (HCWs) are among the highest risk groups for infection. The current study aimed to evaluate COVID-19 vaccine acceptance among HCWs in Kuwait, with identification of the psychological determinants of COVID-19 vaccine hesitancy. The study was conducted using an online anonymous survey distributed between 18 March 2021 and 29 March 2021. The sampling strategy was convenience-based depending on chain-referral sampling. Psychological determinants of COVID-19 vaccine acceptance were assessed using the 5C subscales and the Vaccine Conspiracy Beliefs Scale (VCBS). The total number of study participants was 1019, with the largest group being physicians (28.7%), pharmacists (20.2%), dentists (16.7%), and nurses (12.5%). The overall rate for COVID-19 vaccine acceptance was 83.3%, with 9.0% who were not willing to accept vaccination and 7.7% who were unsure. The highest rate for COVID-19 vaccine acceptance was seen among dentists (91.2%) and physicians (90.4%), while the lowest rate was seen among nurses (70.1%; p < 0.001). A higher level of COVID-19 vaccine hesitancy was found among females, participants with a lower educational level, and HCWs in the private sector. A preference for mRNA vaccine technology and Pfizer-BioNTech COVID-19 vaccine was found among the majority of participants (62.6% and 69.7%, respectively). COVID-19 vaccine hesitancy was significantly linked to the embrace of vaccine conspiracy beliefs. The highest 5C psychological predictors of COVID-19 vaccine acceptance were high levels of collective responsibility and confidence, and lower levels of constraints and calculation. The VCBS and 5C subscales (except the calculation subscale) showed acceptable levels of predicting COVID-19 vaccine acceptance based on receiver operating characteristic analyses. The participants who depended on social media platforms, TV programs, and news releases as their main sources of knowledge about COVID-19 vaccines showed higher rates of COVID-19 vaccine hesitancy. An overall satisfactory level of COVID-19 vaccine acceptance was seen among HCWs in Kuwait, which was among the highest rates reported globally. However; higher levels of vaccine hesitancy were observed among certain groups (females, nurses and laboratory workers, HCWs in the private sector), which should be targeted with more focused awareness programs. HCWs in Kuwait can play a central role in educating their patients and the general public about the benefits of COVID-19 vaccination to halt the spread of SARS-CoV-2, considering the high rates of vaccine hesitancy observed among the general public in Kuwait and the Middle East.", "doi": "10.3390/vaccines9070701", "pmid": "34202298", "labels": {"Category: Public Health": null, "Type: Review": null}, "xrefs": [{"db": "pii", "key": "vaccines9070701"}], "notes": [], "created": "2021-07-05T14:33:44.839Z", "modified": "2021-07-14T11:17:15.465Z"}, {"entity": "publication", "iuid": "16fd40dde240457d8dbea892eeff3089", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16fd40dde240457d8dbea892eeff3089.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16fd40dde240457d8dbea892eeff3089"}}, "title": "Nuclear factor-kappa B and its role in inflammatory lung disease.", "authors": [{"family": "Alharbi", "given": "Khalid Saad", "initials": "KS"}, {"family": "Fuloria", "given": "Neeraj Kumar", "initials": "NK"}, {"family": "Fuloria", "given": "Shivkanya", "initials": "S"}, {"family": "Rahman", "given": "Sk Batin", "initials": "SB"}, {"family": "Al-Malki", "given": "Waleed Hassan", "initials": "WH"}, {"family": "Javed Shaikh", "given": "Mohammad Arshad", "initials": "MA"}, {"family": "Thangavelu", "given": "Lakshmi", "initials": "L"}, {"family": "Singh", "given": "Sachin K", "initials": "SK"}, {"family": "Rama Raju", "given": "Venkata Sita", "initials": "VS"}, {"family": "Jha", "given": "Niraj Kumar", "initials": "NK"}, {"family": "Chellappan", "given": "Dinesh Kumar", "initials": "DK"}, {"family": "Dua", "given": "Kamal", "initials": "K"}, {"family": "Gupta", "given": "Gaurav", "initials": "G"}], "type": "journal article", "published": "2021-06-25", "journal": {"title": "Chem Biol Interact", "issn": "1872-7786", "pages": "109568", "issn-l": null}, "abstract": "Nuclear factor-kappa B, involved in inflammation, host immune response, cell adhesion, growth signals, cell proliferation, cell differentiation, and apoptosis defense, is a dimeric transcription factor. Inflammation is a key component of many common respiratory disorders, including asthma, COPD, bronchiectasis, and acute respiratory distress syndrome. Many basic transcription factors are found in NF-\u03baB, which is a member of the Rel protein family. Five members of this family c-REL, NF-\u03baB2 (p100/p52), RelA (p65), NF-\u03baB1 (p105/p50), RelB, and RelA (p65) produce 5 transcriptionally active molecules. Proinflammatory cytokines, T lymphocyte, and B lymphocyte cell mitogens, lipopolysaccharides, bacteria, viral proteins, viruses, double-stranded RNA, oxidative stress, physical exertion, various chemotherapeutics are the stimulus responsible for NF-\u03baB activation. NF-\u03baB act as a principal component for several common respiratory illnesses, such as asthma, lung cancer, pulmonary fibrosis, COPD as well as infectious diseases like pneumonia, tuberculosis, COVID-19. Inflammatory lung disease, especially COVID-19, can make NF-\u03baB a key target for drug production.", "doi": "10.1016/j.cbi.2021.109568", "pmid": "34181887", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0009-2797(21)00206-4"}], "notes": [], "created": "2021-06-30T04:57:33.760Z", "modified": "2021-06-30T04:57:44.179Z"}, {"entity": "publication", "iuid": "352d0e4195ea4501abf1525b7513be07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/352d0e4195ea4501abf1525b7513be07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/352d0e4195ea4501abf1525b7513be07"}}, "title": "Lifestyle changes during the first wave of the COVID-19 pandemic: a cross-sectional survey in the Netherlands.", "authors": [{"family": "van der Werf", "given": "Esther T", "initials": "ET"}, {"family": "Busch", "given": "Martine", "initials": "M"}, {"family": "Jong", "given": "Miek C", "initials": "MC"}, {"family": "Hoenders", "given": "H J Rogier", "initials": "HJR"}], "type": "journal article", "published": "2021-06-25", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "1226"}, "abstract": "During the Covid-19 pandemic the Dutch government implemented its so-called 'intelligent lockdown' in which people were urged to leave their homes as little as possible and work from home. This life changing event may have caused changes in lifestyle behaviour, an important factor in the onset and course of diseases. The overarching aim of this study is to determine life-style related changes during the first wave of the COVID-19 pandemic among a representative sample of the adult population in the Netherlands.\r\n\r\nLife-style related changes were studied among a random representative sample of the adult population in the Netherlands using an online survey conducted from 22 to 27 May 2020. Differences in COVID-19-related lifestyle changes between Complementary and Alternative Medicine (CAM) users and non-CAM users were determined. The survey included a modified version of the I-CAM-Q and 26 questions on lifestyle related measures, anxiety, and need for support to maintain lifestyle changes.\r\n\r\n1004 respondents were included in the study, aged between 18 and 88 years (50.7% females). Changes to a healthier lifestyle were observed in 19.3% of the population, mainly due to a change in diet habits, physical activity and relaxation, of whom 56.2% reported to be motivated to maintain this behaviour change in a post-COVID-19 era. Fewer respondents (12.3%) changed into an unhealthier lifestyle. Multivariable logistic regression analyses revealed that changing into a healthier lifestyle was positively associated with the variables 'Worried/Anxious getting COVID-19' (OR: 1.56, 95% C.I. 1.26-1.93), 'CAM use' (OR: 2.04, 95% C.I. 1.38-3.02) and 'stress in relation to financial situation' (OR: 1.89, 95% C.I. 1.30-2.74). 'Age' (OR 18-25: 1.00, OR 25-40: 0.55, 95% C.I. 0.31-0.96, OR 40-55:0.50 95% C.I. 0.28-0.87 OR 55+: 0.1095% C.I. 0.10-0.33), 'stress in relation to health' (OR: 2.52, 95% C.I. 1.64-3.86) and 'stress in relation to the balance work and home' (OR: 1.69, 95% C.I. 1.11-2.57) were found predicting the change into an unhealthier direction.\r\n\r\nThese findings suggest that the coronavirus crisis resulted in a healthier lifestyle in one part and, to a lesser extent, in an unhealthier lifestyle in another part of the Dutch population. Further studies are warranted to see whether this behavioural change is maintained over time, and how different lifestyle factors can affect the susceptibility for and the course of COVID-19.", "doi": "10.1186/s12889-021-11264-z", "pmid": "34172042", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11264-z"}], "notes": [], "created": "2021-06-28T18:11:12.503Z", "modified": "2021-07-14T11:18:29.701Z"}, {"entity": "publication", "iuid": "6aa9df86d6284fd6815f332f6cf4d361", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6aa9df86d6284fd6815f332f6cf4d361.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6aa9df86d6284fd6815f332f6cf4d361"}}, "title": "Extended theory of planned behavior in explaining the intention to COVID-19 vaccination uptake among mainland Chinese university students: an online survey study", "authors": [{"family": "Fan", "given": "Chia Wei", "initials": "CW"}, {"family": "Chen", "given": "I Hua", "initials": "IH", "orcid": "0000-0001-6999-6406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/832b240d9a32490da7c16ec117cf5dbf.json"}}, {"family": "Ko", "given": "Nai Ying", "initials": "NY", "orcid": "0000-0002-3007-2537", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bcdd2c7f1bf84efb9c8b95bcb498c8cb.json"}}, {"family": "Yen", "given": "Cheng Fang", "initials": "CF"}, {"family": "Lin", "given": "Chung Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal-article", "published": "2021-06-25", "journal": {"title": "Human Vaccines & Immunotherapeutics", "issn": "2164-5515", "pages": "1-8", "issn-l": null}, "abstract": null, "doi": "10.1080/21645515.2021.1933687", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:12:19.308Z", "modified": "2021-06-28T18:12:19.466Z"}, {"entity": "publication", "iuid": "2e957843514442c6a758bf3ed5620021", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e957843514442c6a758bf3ed5620021.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e957843514442c6a758bf3ed5620021"}}, "title": "COVID-19 Transmission due to Mass Mobility Before and After the Largest Festival in Bangladesh: An Epidemiologic Study.", "authors": [{"family": "Rahman", "given": "Farah Naz", "initials": "FN"}, {"family": "Rahman", "given": "A K M Fazlur", "initials": "AKMF"}, {"family": "Iwuagwu", "given": "Anthony Obinna", "initials": "AO"}, {"family": "Dalal", "given": "Koustuv", "initials": "K"}], "type": "journal article", "published": "2021-06-25", "journal": {"title": "Inquiry", "issn": "1945-7243", "issn-l": null, "volume": "58", "issue": null, "pages": "469580211023464"}, "abstract": "Festivals traditionally result in mass public mobility from large cities to rural or semi-urban areas in low- and middle-Income Countries (LMIC), which are inadequately prepared for tackling the consequences of the COVID-19 pandemic. This study aimed to explore the trend of COVID-19 infection in a peripheral region of Bangladesh during one of the largest festivals to develop an evidence-based hypothesis for its influence on the transmission rate of COVID-19. This study conducted a quantitative analysis of secondary data on COVID-19 collected from the Directorate General of Health Services Bangladesh (DGHS) and divisional director's office in the Mymensingh division. To explore the influence of one of the biggest festivals (Eid-ul-Adha) on the trend of COVID-19 infection, we analyzed data from a week before the festival to 2 weeks following the festival. The infection rate (positive cases per million of the population) and the test positivity rate (positive cases among the total number of conducted diagnostic tests) of each day during this period were calculated both for the Mymensingh region and national level. Both the test positivity rate (TPR) and infection rates in the Mymensingh region demonstrated an increasing trend. The mean test positivity rate of the Mymensingh region on the week before the festival was 9.5%. It increased to a mean test positivity rate of 13% in the following week and further rose to a rate of 17% in the next week. The infection rate of Mymensingh also increased more than 2 folds from the day of the festival (2.0-5.3 cases per million) within the next 2 weeks. The TPR and infection rate on the national level remained similar throughout the study period. Mass mobility during Eid-ul-Adha influences the increased transmission of COVID-19 among the peripheral regions of Bangladesh from the central capital city Dhaka. The findings will help policymakers plan and implement travel restrictions during festivals during the pandemic in LMICs.", "doi": "10.1177/00469580211023464", "pmid": "34166134", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:15:05.881Z", "modified": "2021-07-14T11:19:15.484Z"}, {"entity": "publication", "iuid": "234fc3388f0546a9a405eafcba15f5bb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/234fc3388f0546a9a405eafcba15f5bb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/234fc3388f0546a9a405eafcba15f5bb"}}, "title": "Suggested treatment of serious complications to Covid\u201019 vaccination with IdeS, a bacterial antibody\u2010cleaving enzyme", "authors": [{"family": "Kahn", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-5566-6350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42eda71f3775400599febc10a4e7359c.json"}}, {"family": "Shannon", "given": "Oonagh", "initials": "O", "orcid": "0000-0001-8291-8189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7fad6031e2f4a84a8ede77911d3c542.json"}}, {"family": "Bj\u00f6rck", "given": "Lars", "initials": "L"}], "type": "journal-article", "published": "2021-06-24", "journal": {"title": "J Thromb Haemost", "issn": "1538-7836", "issn-l": null}, "abstract": null, "doi": "10.1111/jth.15433", "pmid": null, "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:15:49.076Z", "modified": "2021-06-30T05:08:56.397Z"}, {"entity": "publication", "iuid": "0ac0332baa1f45c4aa00387bcc5c8b14", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ac0332baa1f45c4aa00387bcc5c8b14.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ac0332baa1f45c4aa00387bcc5c8b14"}}, "title": "Risk of SARS-CoV-2 infection and subsequent hospital admission and death at different time intervals since first dose of COVID-19 vaccine administration, Italy, 27 December 2020 to mid-April 2021", "authors": [{"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Spila Alegiani", "given": "Stefania", "initials": "S"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Filia", "given": "Antonietta", "initials": "A"}, {"family": "Massari", "given": "Marco", "initials": "M"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Tallon", "given": "Marco", "initials": "M"}, {"family": "Proietti", "given": "Valeria", "initials": "V"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Puopolo", "given": "Maria", "initials": "M"}, {"family": "Spuri", "given": "Matteo", "initials": "M"}, {"family": "Morciano", "given": "Cristina", "initials": "C"}, {"family": "D\u2019Ancona", "given": "Fortunato (Paolo)", "initials": "F("}, {"family": "Da Cas", "given": "Roberto", "initials": "R"}, {"family": "Battilomo", "given": "Serena", "initials": "S"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Menniti-Ippolito", "given": "Francesca", "initials": "F"}, {"family": "None", "given": "", "initials": ""}, {"family": "None", "given": "", "initials": ""}], "type": "journal-article", "published": "2021-06-24", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "25", "pages": null}, "abstract": null, "doi": "10.2807/1560-7917.es.2021.26.25.2100507", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:13:29.956Z", "modified": "2021-07-14T11:16:12.655Z"}, {"entity": "publication", "iuid": "16fa3d7c7cdc4a339271cff87092d7c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16fa3d7c7cdc4a339271cff87092d7c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16fa3d7c7cdc4a339271cff87092d7c0"}}, "title": "Evolution, Correlation, Structural Impact and Dynamics of Emerging SARS-CoV-2 Variants.", "authors": [{"family": "Spratt", "given": "Austin N", "initials": "AN"}, {"family": "Kannan", "given": "Saathvik R", "initials": "SR"}, {"family": "Woods", "given": "Lucas T", "initials": "LT"}, {"family": "Weisman", "given": "Gary A", "initials": "GA"}, {"family": "Quinn", "given": "Thomas P", "initials": "TP"}, {"family": "Lorson", "given": "Christian L", "initials": "CL"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}, {"family": "Singh", "given": "Kamal", "initials": "K"}], "type": "journal article", "published": "2021-06-24", "journal": {"title": "Comput Struct Biotechnol J", "issn": "2001-0370", "issn-l": "2001-0370"}, "abstract": "Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infections remain unmanageable in some parts of the world. As with other RNA viruses, mutations in the SARS-CoV-2 gene have been continuously evolving. Recently, four variants have been identified, B.1.1.7, B.1.351, P.1 and CAL.20C. These variants appear to be more infectious and transmissible than the original Wuhan-Hu-1 virus. Using a combination of bioinformatics and structural analyses, we show that the new SARS-CoV-2 variants emerged in the background of an already known Spike protein mutation D614G together with another mutation P323L in the RNA polymerase of SARS-CoV-2. The phylogenetic analysis showed that the CAL.20C and B.1.351 shared one common ancestor, whereas the B.1.1.7 and P.1 shared a different ancestor. Structural comparisons did not show any significant difference between the wild-type and mutant ACE2/Spike complexes. Structural analysis indicated that the N501Y mutation may increase hydrophobic interactions at the ACE2/Spike interface. However, reported greater binding affinity of N501Y Spike with ACE2 does not seem to be entirely due to increased hydrophobic interactions, given that Spike mutation R417T in P.1 or K417N in B.1.351 results in the loss of a salt-bridge interaction between ACE2 and S-RBD. The calculated change in free energy did not provide a clear trend of S protein stability of mutations in the variants. As expected, we show that the CAL.20C generally migrated from the west coast to the east coast of the USA. Taken together, the analyses suggest that the evolution of variants and their infectivity is complex and may depend upon many factors.", "doi": "10.1016/j.csbj.2021.06.037", "pmid": "34188776", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2001-0370(21)00275-0"}, {"db": "pmc", "key": "PMC8225291"}], "notes": [], "created": "2021-07-05T14:24:05.957Z", "modified": "2021-07-05T14:24:05.969Z"}, {"entity": "publication", "iuid": "b8075ce5a3464e22a6ce2f9b1cfdc626", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8075ce5a3464e22a6ce2f9b1cfdc626.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8075ce5a3464e22a6ce2f9b1cfdc626"}}, "title": "Detection and viral RNA shedding of SARS-CoV-2 in respiratory specimens relative to symptom onset among COVID-19 patients in Bavaria, Germany.", "authors": [{"family": "Woudenberg", "given": "Tom", "initials": "T", "orcid": "0000-0002-5675-7470", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9992ee28624349caaa1984823c705bf4.json"}}, {"family": "Eberle", "given": "Ute", "initials": "U"}, {"family": "Marosevic", "given": "Durdica", "initials": "D"}, {"family": "Liebl", "given": "Bernhard", "initials": "B"}, {"family": "Ackermann", "given": "Nikolaus", "initials": "N"}, {"family": "Katz", "given": "Katharina", "initials": "K"}, {"family": "Sing", "given": "Andreas", "initials": "A", "orcid": "0000-0003-1619-6047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3be5645dc94443809ebedaef2961294a.json"}}, {"family": "Bavarian SARS-CoV-2-Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-06-23", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "issn-l": null, "volume": "149", "issue": null, "pages": "e150"}, "abstract": "We assessed severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) reverse transcriptase-polymerase chain reaction (RT-PCR) diagnostic sensitivity and cycle threshold (Ct) values relative to symptom onset in symptomatic coronavirus disease-2019 (COVID-19) patients from Bavaria, Germany, of whom a subset was repeatedly tested. Locally weighted scatterplot smoothing method was used to assess the relationship between symptom onset and Ct-values. Kaplan-Meier plots were used to visualise the empirical probability of detecting viral ribonucleic acid (RNA) over time and estimate the time until clearance of viral RNA among the repeatedly tested patients. Among 721 reported COVID-19 cases, the viral RNA was detected in specimens taken between three days before and up to 48 days after symptom onset. The mean Ct-value was 28.6 (95% confidence interval (CI) 28.2-29.0) with the lowest mean Ct-value (26.2) observed two days after symptom onset. Up to 7 days after symptom onset, the diagnostic sensitivity of the RT-PCR among repeatedly sampled patients (n = 208) remained above 90% and decreased to 50% at day 12 (95% CI 10.5-21.5). Our data provide valuable estimates to optimise the timing of sampling of individuals for SARS-CoV-2 detection. A considerable proportion of specimens sampled before symptom onset had Ct-values comparable with Ct-values after symptom onset, suggesting the probability of presymptomatic transmission.", "doi": "10.1017/S0950268821001345", "pmid": "34158139", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8314058"}, {"db": "pii", "key": "S0950268821001345"}], "notes": [], "created": "2021-06-28T18:18:35.200Z", "modified": "2023-06-19T15:23:52.921Z"}, {"entity": "publication", "iuid": "66f436ea105e4dd29af69fbafc5e18c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66f436ea105e4dd29af69fbafc5e18c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66f436ea105e4dd29af69fbafc5e18c5"}}, "title": "COVseq is a cost-effective workflow for mass-scale SARS-CoV-2 genomic surveillance.", "authors": [{"family": "Simonetti", "given": "Michele", "initials": "M", "orcid": "0000-0003-3322-1697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1382a34459c64b839f1d7889625c374c.json"}}, {"family": "Zhang", "given": "Ning", "initials": "N", "orcid": "0000-0002-6430-4236", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/866db18024634b20af9872a97c716be2.json"}}, {"family": "Harbers", "given": "Luuk", "initials": "L", "orcid": "0000-0003-3910-6497", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2f9ea2325db4f6fab536fe923f90bf3.json"}}, {"family": "Milia", "given": "Maria Grazia", "initials": "MG"}, {"family": "Brossa", "given": "Silvia", "initials": "S"}, {"family": "Huong Nguyen", "given": "Thi Thu", "initials": "TT", "orcid": "0000-0002-9089-7370", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b366997bbc1645828d0ea10cc1c8ad0e.json"}}, {"family": "Cerutti", "given": "Francesco", "initials": "F", "orcid": "0000-0003-0480-8296", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05159eca599748f6b79857bb726200c1.json"}}, {"family": "Berrino", "given": "Enrico", "initials": "E"}, {"family": "Sapino", "given": "Anna", "initials": "A"}, {"family": "Bienko", "given": "Magda", "initials": "M", "orcid": "0000-0002-6499-9082", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa0cd262fa184872b92d7589a2cc2d62.json"}}, {"family": "Sottile", "given": "Antonino", "initials": "A"}, {"family": "Ghisetti", "given": "Valeria", "initials": "V", "orcid": "0000-0002-4698-598X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3aebeae45cb44e4691c4d3fc468f8699.json"}}, {"family": "Crosetto", "given": "Nicola", "initials": "N", "orcid": "0000-0002-3019-6978", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc7960c369064c89a193bd94b598d12d.json"}}], "type": "journal article", "published": "2021-06-23", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "3903"}, "abstract": "While mass-scale vaccination campaigns are ongoing worldwide, genomic surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to monitor the emergence and global spread of viral variants of concern (VOC). Here, we present a streamlined workflow-COVseq-which can be used to generate highly multiplexed sequencing libraries compatible with Illumina platforms from hundreds of SARS-CoV-2 samples in parallel, in a rapid and cost-effective manner. We benchmark COVseq against a standard library preparation method (NEBNext) on 29 SARS-CoV-2 positive samples, reaching 95.4% of concordance between single-nucleotide variants detected by both methods. Application of COVseq to 245 additional SARS-CoV-2 positive samples demonstrates the ability of the method to reliably detect emergent VOC as well as its compatibility with downstream phylogenetic analyses. A cost analysis shows that COVseq could be used to sequence thousands of samples at less than 15 USD per sample, including library preparation and sequencing costs. We conclude that COVseq is a versatile and scalable method that is immediately applicable for SARS-CoV-2 genomic surveillance and easily adaptable to other pathogens such as influenza viruses.", "doi": "10.1038/s41467-021-24078-9", "pmid": "34162869", "labels": {"Research Area: Viral sequence evolution": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-24078-9"}, {"db": "pmc", "key": "PMC8222401"}], "notes": [], "created": "2021-06-23T11:59:06.941Z", "modified": "2021-12-11T05:55:57.605Z"}, {"entity": "publication", "iuid": "be10034a6b7e4a398b1da679f17fedba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be10034a6b7e4a398b1da679f17fedba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be10034a6b7e4a398b1da679f17fedba"}}, "title": "Who should be tested in a pandemic? Ethical considerations.", "authors": [{"family": "Hansson", "given": "Sven Ove", "initials": "SO", "orcid": "0000-0003-0071-3919", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44c820ae26d9495684ea585732835a69.json"}}, {"family": "Helgesson", "given": "Gert", "initials": "G"}, {"family": "Juth", "given": "Niklas", "initials": "N"}], "type": "journal article", "published": "2021-06-22", "journal": {"title": "BMC Med Ethics", "issn": "1472-6939", "volume": "22", "issue": "1", "pages": "76", "issn-l": null}, "abstract": "In the initial phase of the Covid-19 pandemic, difficult decisions had to be made on the allocation of testing resources. Similar situations can arise in future pandemics. Therefore, careful consideration of who should be tested is an important part of pandemic preparedness. We focus on four ethical aspects of that problem: how to prioritize scarce testing resources, the regulation of commercial direct-to-consumer test services, testing of unauthorized immigrants, and obligatory testing.\n\nThe distribution of scarce resources for testing: We emphasize the use of needs-based criteria, but also acknowledge the importance of choosing a testing strategy that contributes efficiently to stopping the overall spread of the disease. Commercial direct-to-consumer test services: Except in cases of acute scarcity, such services will in practice have to be allowed. We propose that they should be subject to regulation that ensures test quality and adequate information to users. Testing of unauthorized immigrants, their children and other people with unclear legal status: Like everyone else, these individuals may be in need of testing, and it is in society's interest to reach them with testing in order to stop the spread of the disease. A society that offers comprehensive medical services to unauthorized immigrants is in a much better position to reach them in a pandemic than a society that previously excluded them from healthcare. Obligatory testing: While there are often strong reasons for universal testing in residential areas or on workplaces, there are in most cases better ways to achieve testing coverage than to make testing mandatory.\n\nIn summary, we propose (1) decision-making primarily based on needs-based criteria, (2) strict regulation but not prohibition of direct-to-consumer test services, (3) test services offered to unauthorized immigrants, preferably as part of comprehensive medical services, and (4) broad outreach of testing services whenever possible, but in general not obligatory testing.", "doi": "10.1186/s12910-021-00640-4", "pmid": "34158041", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12910-021-00640-4"}, {"db": "pmc", "key": "PMC8218570"}], "notes": [], "created": "2021-06-28T18:18:53.622Z", "modified": "2021-06-28T18:18:53.673Z"}, {"entity": "publication", "iuid": "906776760124487f9e2989bb99a3f45d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/906776760124487f9e2989bb99a3f45d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/906776760124487f9e2989bb99a3f45d"}}, "title": "Recent MMR vaccination in health care workers and Covid-19: A test negative case-control study.", "authors": [{"family": "Lundberg", "given": "Lisa", "initials": "L"}, {"family": "Bygdell", "given": "Maria", "initials": "M"}, {"family": "Stukat von Feilitzen", "given": "Gustaf", "initials": "G"}, {"family": "Woxenius", "given": "Susanne", "initials": "S"}, {"family": "Ohlsson", "given": "Claes", "initials": "C"}, {"family": "Kindblom", "given": "Jenny M", "initials": "JM"}, {"family": "Leach", "given": "Susannah", "initials": "S"}], "type": "journal article", "published": "2021-06-22", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null}, "abstract": "It has been hypothesised that the measles-mumps-rubella (MMR) vaccine may afford cross-protection against SARS-CoV-2 which may contribute to the wide variability in disease severity of Covid-19.\n\nWe employed a test negative case-control study, utilising a recent measles outbreak during which many healthcare workers received the MMR vaccine, to investigate the potential protective effect of MMR against SARS-CoV-2 in 5905 subjects (n = 805 males, n = 5100 females).\n\nThe odds ratio for testing positive for SARS-CoV-2, in recently MMR-vaccinated compared to not recently MMR-vaccinated individuals was 0.91 (95% CI 0.76, 1.09). An interaction analysis showed a significant interaction for sex. After sex-stratification, the odds ratio for testing positive for males was 0.43 (95% CI 0.24, 0.79, P = 0.006), and 1.01 (95% CI 0.83, 1.22, P = 0.92) for females.\n\nOur results indicate that there may be a protective effect of the MMR vaccine against SARS-CoV-2 in males but not females.", "doi": "10.1016/j.vaccine.2021.06.045", "pmid": "34187707", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(21)00795-7"}, {"db": "pmc", "key": "PMC8216866"}], "notes": [], "created": "2021-07-05T14:22:17.192Z", "modified": "2021-07-05T14:22:40.368Z"}, {"entity": "publication", "iuid": "abf861e7ee84401fa61a6a136b81d21b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abf861e7ee84401fa61a6a136b81d21b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abf861e7ee84401fa61a6a136b81d21b"}}, "title": "Obesity Strongly Predicts COVID-19-Related Major Clinical Adverse Events in Coptic Clergy.", "authors": [{"family": "Henein", "given": "Michael Y", "initials": "MY", "orcid": "0000-0002-6089-5614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe79bb10eb4348948599443b7b396faf.json"}}, {"family": "Byty\u00e7i", "given": "Ibadete", "initials": "I", "orcid": "0000-0002-8996-4257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba2f218876104573a8e529b1c2b6f671.json"}}, {"family": "Nicoll", "given": "Rachel", "initials": "R"}, {"family": "Shenouda", "given": "Rafik", "initials": "R"}, {"family": "Ayad", "given": "Sherif", "initials": "S", "orcid": "0000-0002-1737-0142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6bd437e0e8d54056959e5077471e1542.json"}}, {"family": "Vancheri", "given": "Federico", "initials": "F"}, {"family": "Cameli", "given": "Matteo", "initials": "M", "orcid": "0000-0003-3872-8964", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e64899d051a84cd8a0cac5f503e03251.json"}}], "type": "journal article", "published": "2021-06-22", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "10", "issue": "13", "issn-l": "2077-0383"}, "abstract": "The Coptic clergy, due to their specific work involving interaction with many people, could be subjected to increased risk of infection from COVID-19. The aim of this study, a sub-study of the COVID-19-CVD international study of the impact of the pandemic on the cardiovascular system, was to assess the prevalence of COVID-19 among Coptic priests and to identify predictors of clinical adverse events.\n\nParticipants were geographically divided into three groups: Group-I: Europe and USA, Group II: Northern Egypt, and Group III: Southern Egypt. Participants' demographic indices, cardiovascular risk factors, possible source of infection, number of liturgies, infection management, and major adverse events (MAEs), comprising death, or mechanical ventilation, were assessed.\n\nOut of the 1570 clergy serving in 25 dioceses, 255 (16.2%) were infected. Their mean age was 49.5 \u00b1 12 years and mean weekly number of liturgies was 3.44 \u00b1 1.0. The overall prevalence rate was 16.2% and did not differ between Egypt as a whole and overseas (p = 0.23). Disease prevalence was higher in Northern Egypt clergy compared with Europe and USA combined (18.4% vs. 12.1%, p = 0.03) and tended to be higher than in Southern Egypt (18.4% vs. 13.6%, p = 0.09). Ten priests (3.92%) died of COVID-19-related complications, and 26 (10.2) suffered a MAE. The clergy from Southern Egypt were more obese, but the remaining risk factors were less prevalent compared with those in Europe and USA (p = 0.01). In multivariate analysis, obesity (OR = 4.180; 2.479 to 12.15; p = 0.01), age (OR = 1.055; 0.024 to 1.141; p = 0.02), and systemic hypertension (OR = 1.931; 1.169 to 2.004; p = 0.007) predicted MAEs. Obesity was the most powerful independent predictor of MAE in Southern Egypt and systemic hypertension in Northern Egypt (p < 0.05 for both).\n\nObesity is very prevalent among Coptic clergy and seems to be the most powerful independent predictor of major COVID-19-related adverse events. Coptic clergy should be encouraged to follow the WHO recommendations for cardiovascular disease and COVID-19 prevention.", "doi": "10.3390/jcm10132752", "pmid": "34206658", "labels": {"Type: Review": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "jcm10132752"}], "notes": [], "created": "2021-07-05T14:36:08.009Z", "modified": "2021-07-05T14:36:08.112Z"}, {"entity": "publication", "iuid": "711c5ab1909448a5aef6875fa091021f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/711c5ab1909448a5aef6875fa091021f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/711c5ab1909448a5aef6875fa091021f"}}, "title": "Fear of COVID-19 and Perceived COVID-19 Infectability Supplement Theory of Planned Behavior to Explain Iranians' Intention to Get COVID-19 Vaccinated.", "authors": [{"family": "Yahaghi", "given": "Rafat", "initials": "R"}, {"family": "Ahmadizade", "given": "Safie", "initials": "S"}, {"family": "Fotuhi", "given": "Razie", "initials": "R"}, {"family": "Taherkhani", "given": "Elham", "initials": "E"}, {"family": "Ranjbaran", "given": "Mehdi", "initials": "M", "orcid": "0000-0002-0313-3373", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6b9820cfd99430a938c9653d46f6322.json"}}, {"family": "Buchali", "given": "Zeinab", "initials": "Z"}, {"family": "Jafari", "given": "Robabe", "initials": "R"}, {"family": "Zamani", "given": "Narges", "initials": "N"}, {"family": "Shahbazkhania", "given": "Azam", "initials": "A"}, {"family": "Simiari", "given": "Hengame", "initials": "H"}, {"family": "Rahmani", "given": "Jalal", "initials": "J"}, {"family": "Yazdi", "given": "Nahid", "initials": "N"}, {"family": "Alijani", "given": "Hashem", "initials": "H"}, {"family": "Poorzolfaghar", "given": "Leila", "initials": "L"}, {"family": "Rajabi", "given": "Fatemeh", "initials": "F"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-06-22", "journal": {"title": "Vaccines", "issn": "2076-393X", "issn-l": null, "volume": "9", "issue": "7", "pages": "684"}, "abstract": "One of the most efficient methods to control the high infection rate of the coronavirus disease 2019 (COVID-19) is to have a high coverage of COVID-19 vaccination worldwide. Therefore, it is important to understand individuals' intention to get COVID-19 vaccinated. The present study applied the Theory of Planned Behavior (TPB) to explain the intention to get COVID-19 vaccinated among a representative sample in Qazvin, Iran. The TPB uses psychological constructs of attitude, subjective norm, and perceived behavioral control to explain an individual's intention to perform a behavior. Fear and perceived infectability were additionally incorporated into the TPB to explain the intention to get COVID-19 vaccinated. Utilizing multistage stratified cluster sampling, 10,843 participants (4092 males; 37.7%) with a mean age of 35.54 years (SD = 12.00) completed a survey. The survey assessed TPB constructs (including attitude, subjective norm, perceived behavioral control, and intention related to COVID-19 vaccination) together with fear of COVID-19 and perceived COVID-19 infectability. Structural equation modeling (SEM) was performed to examine whether fear of COVID-19, perceived infectability, and the TPB constructs explained individuals' intention to get COVID-19 vaccinated. The SEM demonstrated satisfactory fit (comparative fit index = 0.970; Tucker-Lewis index = 0.962; root mean square error of approximation = 0.040; standardized root mean square residual = 0.050). Moreover, perceived behavioral control, subjective norm, attitude, and perceived COVID-19 infectability significantly explained individuals' intention to get COVID-19 vaccinated. Perceived COVID-19 infectability and TPB constructs were all significant mediators in the relationship between fear of COVID-19 and intention to get COVID-19 vaccinated. Incorporating fear of COVID-19 and perceived COVID-19 infectability effectively into the TPB explained Iranians' intention to get COVID-19 vaccinated. Therefore, Iranians who have a strong belief in Muslim religion may improve their intention to get COVID-19 vaccinated via these constructs.", "doi": "10.3390/vaccines9070684", "pmid": "34206226", "labels": {"Category: Public Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8310138"}, {"db": "pii", "key": "vaccines9070684"}], "notes": [], "created": "2021-07-05T14:35:28.108Z", "modified": "2023-06-19T15:21:14.367Z"}, {"entity": "publication", "iuid": "a072af27feb64a60bed14b2e4089a3d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a072af27feb64a60bed14b2e4089a3d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a072af27feb64a60bed14b2e4089a3d4"}}, "title": "Adapting the Motors of Influenza Vaccination Acceptance Scale into the Motors of COVID-19 Vaccination Acceptance Scale: Psychometric evaluation among mainland Chinese university students.", "authors": [{"family": "Chen", "given": "I-Hua", "initials": "IH"}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Ko", "given": "Nai-Ying", "initials": "NY"}, {"family": "Yen", "given": "Cheng-Fang", "initials": "CF"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-06-22", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null}, "abstract": "COVID-19 continues to ravage the world with economies and life significantly and negatively affected. Fortunately, there has been significant progress in the production of vaccines to stem the infection. However, with controversies and myths surrounding vaccinations, it is timely to examine individuals' willingness to vaccinate. The present study adapted the Motors of Influenza Vaccination Acceptance Scale (MoVac-Flu Scale) into the Motors of COVID-19 Vaccination Acceptance Scale (MoVac-COVID19S) for validation and assessed the acceptance of COVID-19 vaccination utilizing the cognitive model of empowerment (CME).\n\nA total of 3145 university students (mean age = 20.80 years; SD = 2.09) were recruited for the present study between January 5 and 16, 2021. Two MoVac-COVID19S scales (9-item and 12-item) were adapted from the MoVac-Flu Scale, an instrument developed using CME. Psychometric tests were conducted to ascertain reliability and validity properties.\n\nThe findings indicated that the MoVac-COVID19S had high internal consistency in both the 9-item version (\u03c9 = 0.921) and 12-item version (\u03c9 = 0.898). The factor structure of the MoVac-COVID19S (9-item and 12-item versions) corresponded well with CME theory. All the fit indices were satisfactory (comparative fit index = 0.984, Tucker-Lewis index = 0.971, root mean square error of approximation = 0.088, standardized root mean square residual = 0.058) but the 9-item MoVac-COVID had better fit indices than the 12-item MoVac-COVID due to the negative wording effects existing in the 12-item MoVac-COVID19S. The scale had satisfactory known-group validity in both 9-item and 12-item versions.\n\nThe MoVac-COVID19S has promising psychometric properties based on internal consistency, factor structure, and known-group validity.", "doi": "10.1016/j.vaccine.2021.06.044", "pmid": "34217571", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(21)00794-5"}], "notes": [], "created": "2021-07-05T15:04:14.711Z", "modified": "2021-07-05T15:04:14.722Z"}, {"entity": "publication", "iuid": "d2e4dfecaa2b457ca2deddac6fa256e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d2e4dfecaa2b457ca2deddac6fa256e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d2e4dfecaa2b457ca2deddac6fa256e1"}}, "title": "Problems associated with mass border testing of COVID-19.", "authors": [{"family": "Grun\u00e9r", "given": "Mathias", "initials": "M"}, {"family": "Nordberg", "given": "Marika", "initials": "M"}, {"family": "L\u00f6nnroth", "given": "Knut", "initials": "K"}], "type": "journal article", "published": "2021-06-19", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": null, "issue": null, "pages": "14034948211023659"}, "abstract": "We evaluated the yield of exit screening for SARS-Cov-2 performed in order for travellers to meet entry requirements to Sweden. Among 472 people screened, no infectious case of COVID-19 was detected, while two previously known cases were redetected after having already completed isolation. Our data suggest that depending on the epidemiological situation in the area of departure, border screening can lead to very low positive predictive values and very high costs per relevant case detected.", "doi": "10.1177/14034948211023659", "pmid": "34148440", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:27:36.293Z", "modified": "2021-07-14T11:05:48.211Z"}, {"entity": "publication", "iuid": "c47615463a5942ea9282f007e05a3647", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c47615463a5942ea9282f007e05a3647.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c47615463a5942ea9282f007e05a3647"}}, "title": "Organizational Support Experiences of Care Home and Home Care Staff in Sweden, Italy, Germany and the United Kingdom during the COVID-19 Pandemic", "authors": [{"family": "Lethin", "given": "Connie", "initials": "C", "orcid": "0000-0002-2523-8440", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e4dbde29c2949e09fdeff309bf402e2.json"}}, {"family": "Kenkmann", "given": "Andrea", "initials": "A", "orcid": "0000-0002-9252-2345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5447bed983d94bd3b6ba83eee314ec89.json"}}, {"family": "Chiatti", "given": "Carlos", "initials": "C", "orcid": "0000-0003-4810-9630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7b5ce4271844684965d8c4abe0cd66c.json"}}, {"family": "Christensen", "given": "Jonas", "initials": "J", "orcid": "0000-0003-0428-2001", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/66ccc78bb50f4b37a7365eb8154419a9.json"}}, {"family": "Backhouse", "given": "Tamara", "initials": "T", "orcid": "0000-0001-8194-4174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64556c498dd94570ae0a35f2ae892328.json"}}, {"family": "Killett", "given": "Anne", "initials": "A"}, {"family": "Fisher", "given": "Oliver", "initials": "O", "orcid": "0000-0003-2787-2899", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6f8c5634b75c486b9c00ab54738c43cd.json"}}, {"family": "Malmgren F\u00e4nge", "given": "Agneta", "initials": "A", "orcid": "0000-0002-3165-1856", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b47b1c9adc81409ba189a6cec7643f4a.json"}}], "type": "journal-article", "published": "2021-06-19", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "issn-l": null, "volume": "9", "issue": "6", "pages": "767"}, "abstract": "The COVID-19 pandemic has affected care workers all over the globe, as older and more vulnerable people face a high risk of developing severe symptoms and dying from the virus infection. The aim of this study was to compare staff experiences of stress and anxiety as well as internal and external organizational support in Sweden, Italy, Germany, and the United Kingdom (UK) in order to determine how care staff were affected by the pandemic. A 29-item online questionnaire was used to collect data from care staff respondents: management (n = 136), nurses (n = 132), nursing assistants (n = 195), and other healthcare staff working in these organizations (n = 132). Stress and anxiety levels were highest in the UK and Germany, with Swedish staff showing the least stress. Internal and external support only partially explain the outcomes. Striking discrepancies between different staff groups' assessment of organizational support as well as a lack of staff voice in the UK and Germany could be key factors in understanding staff's stress levels during the pandemic. Structural, political, cultural, and economic factors play a significant role, not only factors within the care organization or in the immediate context.", "doi": "10.3390/healthcare9060767", "pmid": "34205430", "labels": {"Category: Public Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8233956"}, {"db": "pii", "key": "healthcare9060767"}], "notes": [], "created": "2021-07-05T14:34:33.693Z", "modified": "2023-06-19T07:30:08.818Z"}, {"entity": "publication", "iuid": "73dc7c5305684104bbfa82bbc77ab961", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/73dc7c5305684104bbfa82bbc77ab961.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/73dc7c5305684104bbfa82bbc77ab961"}}, "title": "Stable IgG-antibody levels in patients with mild SARS-CoV-2 infection", "authors": [{"family": "\u00c5kerlund", "given": "Thomas", "initials": "T"}, {"family": "Zakikhany", "given": "Katherina", "initials": "K"}, {"family": "L\u00f6fstr\u00f6m", "given": "Charlotta", "initials": "C"}, {"family": "Lindmark", "given": "Evelina", "initials": "E"}, {"family": "K\u00e4llberg", "given": "Henrik", "initials": "H"}, {"family": "Elofsson", "given": "Ulla", "initials": "U"}, {"family": "Cederbrant", "given": "Karin", "initials": "K"}, {"family": "Nygren", "given": "Erik", "initials": "E"}, {"family": "Kallin", "given": "Anders", "initials": "A"}, {"family": "Lagerqvist", "given": "Nina", "initials": "N"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Wollberg", "given": "Anna Ridderstad", "initials": "AR"}, {"family": "Bj\u00f6rndal", "given": "\u00c5sa Szekely", "initials": "\u00c5S"}], "type": "posted-content", "published": "2021-06-18", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.06.16.21258960", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-18T16:39:34.128Z", "modified": "2021-11-18T16:39:50.737Z"}, {"entity": "publication", "iuid": "22939049e0964fe4910f0c36ed045304", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/22939049e0964fe4910f0c36ed045304.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/22939049e0964fe4910f0c36ed045304"}}, "title": "Everyday life in a Swedish nursing home during the COVID-19 pandemic: a qualitative interview study with persons 85 to 100 years.", "authors": [{"family": "Lood", "given": "Qarin", "initials": "Q", "orcid": "0000-0002-6187-0929", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/205301c28ae14612b3df0603d39adabb.json"}}, {"family": "Haak", "given": "Maria", "initials": "M"}, {"family": "Dahlin-Ivanoff", "given": "Synneve", "initials": "S"}], "type": "journal article", "published": "2021-06-18", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "6", "pages": "e048503"}, "abstract": "To understand and report on the impact of the COVID-19 pandemic on the everyday lives of frail older persons living in nursing homes by exploring their experiences of how the pandemic-related restrictions had influenced them and in what way.\n\nEmpirical qualitative interview study.\n\nA publicly run nursing home in an urban area in Sweden in June 2020. The nursing home had visitor restrictions, cancelled activities and physical distancing requirements since March 2020.\n\nA total of 10 persons, 85-100 years, living in a Swedish nursing home during the COVID-19 pandemic, were recruited through nursing home management and interviewed in June 2020 using medically approved visors and physical distancing.\n\nInterviews were analysed using thematic analysis, which involves familiarisation, coding and definition of themes. Transcripts were coded into data-driven categories before being organised into categories that described and explained the data.\n\nThe analysis resulted in the main theme 'It is like living in a bubble', that describes everyday life in the nursing home during the pandemic as a world of its own in which the older persons felt both protected and isolated. This is described in four subthemes: living 1 day at a time, without fear of the virus; feeling taken care of; having limited freedom and missing out on the little extras.\n\nContributing to the growing area of COVID-19-related research, our findings provide novel insights into how pandemic-related restrictions in nursing homes represent a risk of isolating older people from the outside world and diminishing their freedom. Put in relation to the previous research, these findings could be applied beyond the pandemic, to develop research and practice that puts focus on how to support older people to decide for themselves how to spend the rest of their lives.", "doi": "10.1136/bmjopen-2020-048503", "pmid": "34145018", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8214988"}, {"db": "pii", "key": "bmjopen-2020-048503"}], "notes": [], "created": "2021-06-28T18:28:49.224Z", "modified": "2023-06-19T15:05:00.460Z"}, {"entity": "publication", "iuid": "95767140345346129cb142e2870772c7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95767140345346129cb142e2870772c7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95767140345346129cb142e2870772c7"}}, "title": "The Impact of the Renin-Angiotensin-Aldosterone System on Inflammation, Coagulation, and Atherothrombotic Complications, and to Aggravated COVID-19.", "authors": [{"family": "Ekholm", "given": "M", "initials": "M"}, {"family": "Kahan", "given": "T", "initials": "T"}], "type": "journal article", "published": "2021-06-17", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "12", "pages": "640185", "issn-l": "1663-9812"}, "abstract": "Atherosclerosis is considered a disease caused by a chronic inflammation, associated with endothelial dysfunction, and several mediators of inflammation are up-regulated in subjects with atherosclerotic disease. Healthy, intact endothelium exhibits an antithrombotic, protective surface between the vascular lumen and vascular smooth muscle cells in the vessel wall. Oxidative stress is an imbalance between anti- and prooxidants, with a subsequent increase of reactive oxygen species, leading to tissue damage. The renin-angiotensin-aldosterone system is of vital importance in the pathobiology of vascular disease. Convincing data indicate that angiotensin II accelerates hypertension and augments the production of reactive oxygen species. This leads to the generation of a proinflammatory phenotype in human endothelial and vascular smooth muscle cells by the up-regulation of adhesion molecules, chemokines and cytokines. In addition, angiotensin II also seems to increase thrombin generation, possibly via a direct impact on tissue factor. However, the mechanism of cross-talk between inflammation and haemostasis can also contribute to prothrombotic states in inflammatory environments. Thus, blocking of the renin-angiotensin-aldosterone system might be an approach to reduce both inflammatory and thrombotic complications in high-risk patients. During COVID-19, the renin-angiotensin-aldosterone system may be activated. The levels of angiotensin II could contribute to the ongoing inflammation, which might result in a cytokine storm, a complication that significantly impairs prognosis. At the outbreak of COVID-19 concerns were raised about the use of angiotensin converting enzyme inhibitors and angiotensin receptor blocker drugs in patients with COVID-19 and hypertension or other cardiovascular comorbidities. However, the present evidence is in favor of continuing to use of these drugs. Based on experimental evidence, blocking the renin-angiotensin-aldosterone system might even exert a potentially protective influence in the setting of COVID-19.", "doi": "10.3389/fphar.2021.640185", "pmid": "34220496", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "640185"}, {"db": "pmc", "key": "PMC8245685"}], "notes": [], "created": "2021-07-06T05:41:56.778Z", "modified": "2021-08-06T08:53:09.932Z"}, {"entity": "publication", "iuid": "4c9b64be8bb24857b13e370d1b34c219", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4c9b64be8bb24857b13e370d1b34c219.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4c9b64be8bb24857b13e370d1b34c219"}}, "title": "Sphingolipids as Modulators of SARS-CoV-2 Infection.", "authors": [{"family": "T\u00f6rnquist", "given": "Kid", "initials": "K"}, {"family": "Asghar", "given": "Muhammad Yasir", "initials": "MY"}, {"family": "Srinivasan", "given": "Vignesh", "initials": "V"}, {"family": "Korhonen", "given": "Laura", "initials": "L"}, {"family": "Lindholm", "given": "Dan", "initials": "D"}], "type": "journal article", "published": "2021-06-17", "journal": {"title": "Front Cell Dev Biol", "issn": "2296-634X", "volume": "9", "pages": "689854", "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic with severe consequences for afflicted individuals and the society as a whole. The biology and infectivity of the virus has been intensively studied in order to gain a better understanding of the molecular basis of virus-host cell interactions during infection. It is known that SARS-CoV-2 binds to angiotensin-converting enzyme 2 (ACE2) via its spike protein. Priming of the virus by specific proteases leads to viral entry via endocytosis and to the subsequent steps in the life cycle of SARS-CoV-2. Sphingosine and ceramide belong to the sphingolipid family and are abundantly present in cell membranes. These lipids were recently shown to interfere with the uptake of virus particles of SARS-CoV-2 into epithelial cell lines and primary human nasal cells in culture. The mechanisms of action were partly different, as sphingosine blocked, whilst ceramide facilitated viral entry. Acid sphingomyelinase (ASM) is vital for the generation of ceramide and functional inhibition of ASM by drugs like amitriptyline reduced SARS-CoV-2 entry into the epithelial cells. Recent data indicates that serum level of sphingosine-1-phosphate (S1P) is a prognostic factor for COVID-2 severity. Further, stimulation of sphingosine-1-phosphate receptor 1 (S1PR1) might also constrain the hyper-inflammatory conditions linked to SARS-CoV-2. Here, we review recent exciting findings regarding sphingolipids in the uptake of SARS-CoV-2 and in the course of COVID-19 disease. More studies are required on the mechanisms of action and the potential use of antidepressant drugs and sphingolipid modifiers in SARS-CoV-2 infections and in the treatment of the more serious and fatal consequences of the disease.", "doi": "10.3389/fcell.2021.689854", "pmid": "34222257", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8245774"}], "notes": [], "created": "2021-07-06T05:41:28.669Z", "modified": "2021-08-06T08:48:14.607Z"}, {"entity": "publication", "iuid": "8b2f9bd35e10430bb600b4d2574b92bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b2f9bd35e10430bb600b4d2574b92bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b2f9bd35e10430bb600b4d2574b92bd"}}, "title": "Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2.", "authors": [{"family": "Roxhed", "given": "Niclas", "initials": "N", "orcid": "0000-0002-7147-6730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cda793d04e544bbcb7adbd7a8f3de217.json"}}, {"family": "Bendes", "given": "Annika", "initials": "A", "orcid": "0000-0001-9329-2353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87d0283c178b4aaeb0c3f1ad9187de7b.json"}}, {"family": "Dale", "given": "Matilda", "initials": "M", "orcid": "0000-0002-5788-7744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fbf8052f5b8449fabd27adb8316b973.json"}}, {"family": "Mattsson", "given": "Cecilia", "initials": "C"}, {"family": "Hanke", "given": "Leo", "initials": "L", "orcid": "0000-0001-5514-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a35f10de4f2e4aee98278f6ab845613d.json"}}, {"family": "Dodig-Crnkovi\u0107", "given": "Tea", "initials": "T", "orcid": "0000-0002-2875-896X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/63ccd5c5d27e4c11bd60a689e9d4a571.json"}}, {"family": "Christian", "given": "Murray", "initials": "M"}, {"family": "Meineke", "given": "Birthe", "initials": "B"}, {"family": "Els\u00e4sser", "given": "Simon", "initials": "S", "orcid": "0000-0001-8724-4849", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5521b3e3c4fa4e1c8eb4e19a079971a8.json"}}, {"family": "Andr\u00e9ll", "given": "Juni", "initials": "J"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1345-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a53a433db6f04a458e3d420f0c9995c5.json"}}, {"family": "Eklund", "given": "Carina", "initials": "C"}, {"family": "Dillner", "given": "Joakim", "initials": "J", "orcid": "0000-0001-8588-6506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bbb8b0ca5dc648e0b80c1de224b26c69.json"}}, {"family": "Beck", "given": "Olof", "initials": "O"}, {"family": "Thomas", "given": "Cecilia E", "initials": "CE", "orcid": "0000-0001-6201-6380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d34036550b84e67ae3185c65a857c95.json"}}, {"family": "McInerney", "given": "Gerald", "initials": "G", "orcid": "0000-0003-2257-7241", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7770437d845444a8a07865bf5b62fab0.json"}}, {"family": "Hong", "given": "Mun-Gwan", "initials": "MG", "orcid": "0000-0001-8603-8293", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fa0aa1a11e4d2ca5356a8a708536b2.json"}}, {"family": "Murrell", "given": "Ben", "initials": "B", "orcid": "0000-0002-0393-4445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60dac9ecf84d4eb3b90fb4ee1298bc52.json"}}, {"family": "Fredolini", "given": "Claudia", "initials": "C", "orcid": "0000-0002-7674-2014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/680bda0d693149f28ac18dff239101a8.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67a59fa5de37434c8b7151039c192a37.json"}}], "type": "journal article", "published": "2021-06-17", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "3695"}, "abstract": "Serological testing is essential to curb the consequences of the COVID-19 pandemic. However, most assays are still limited to single analytes and samples collected within healthcare. Thus, we establish a multianalyte and multiplexed approach to reliably profile IgG and IgM levels against several versions of SARS-CoV-2 proteins (S, RBD, N) in home-sampled dried blood spots (DBS). We analyse DBS collected during spring of 2020 from 878 random and undiagnosed individuals from the population in Stockholm, Sweden, and use classification approaches to estimate an accumulated seroprevalence of 12.5% (95% CI: 10.3%-14.7%). This includes 5.4% of the samples being IgG+IgM+ against several SARS-CoV-2 proteins, as well as 2.1% being IgG-IgM+ and 5.0% being IgG+IgM- for the virus' S protein. Subjects classified as IgG+ for several SARS-CoV-2 proteins report influenza-like symptoms more frequently than those being IgG+ for only the S protein (OR = 6.1; p < 0.001). Among all seropositive cases, 30% are asymptomatic. Our strategy enables an accurate individual-level and multiplexed assessment of antibodies in home-sampled blood, assisting our understanding about the undiagnosed seroprevalence and diversity of the immune response against the coronavirus.", "doi": "10.1038/s41467-021-23893-4", "pmid": "34140485", "labels": {"Funder: H2020": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Serology": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Host cell systems biology and targets": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8211676"}, {"db": "pii", "key": "10.1038/s41467-021-23893-4"}], "notes": [], "created": "2021-06-18T08:23:45.977Z", "modified": "2023-06-19T14:19:51.535Z"}, {"entity": "publication", "iuid": "0c407443885c4bbe84294a5ea15a53c7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c407443885c4bbe84294a5ea15a53c7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c407443885c4bbe84294a5ea15a53c7"}}, "title": "Extracorporeal membrane oxygenation for COVID-19 during first and second waves.", "authors": [{"family": "Broman", "given": "Lars Mikael", "initials": "LM"}, {"family": "Eksborg", "given": "Staffan", "initials": "S"}, {"family": "Coco", "given": "Valeria Lo", "initials": "VL"}, {"family": "De Piero", "given": "Maria Elena", "initials": "ME"}, {"family": "Belohlavek", "given": "Jan", "initials": "J"}, {"family": "Lorusso", "given": "Roberto", "initials": "R"}, {"family": "EuroECMO COVID-19 Working Group", "given": "", "initials": ""}, {"family": "Euro-ELSO Steering Committee", "given": "", "initials": ""}], "type": "letter", "published": "2021-06-16", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "issn-l": "2213-2600"}, "abstract": null, "doi": "10.1016/S2213-2600(21)00262-9", "pmid": "34146489", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(21)00262-9"}], "notes": [], "created": "2021-06-28T18:28:29.820Z", "modified": "2021-06-28T18:28:29.830Z"}, {"entity": "publication", "iuid": "784a4f6aae174440bf672e8ddc642b24", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/784a4f6aae174440bf672e8ddc642b24.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/784a4f6aae174440bf672e8ddc642b24"}}, "title": "Correction to: Risk of stress/depression and functional impairment in Denmark immediately following a COVID-19 shutdown.", "authors": [{"family": "Andersen", "given": "Lars H", "initials": "LH"}, {"family": "Fallesen", "given": "Peter", "initials": "P"}, {"family": "Bruckner", "given": "Tim A", "initials": "TA"}], "type": "published erratum", "published": "2021-06-16", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "21", "issue": "1", "pages": "1155", "issn-l": null}, "abstract": null, "doi": "10.1186/s12889-021-11204-x", "pmid": "34134702", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11204-x"}, {"db": "pmc", "key": "PMC8206909"}], "notes": [], "created": "2021-06-28T18:42:42.794Z", "modified": "2021-06-28T18:42:42.806Z"}, {"entity": "publication", "iuid": "60d0dac7396d423d8a6e2ada45422709", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60d0dac7396d423d8a6e2ada45422709.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60d0dac7396d423d8a6e2ada45422709"}}, "title": "COVID-19 and Delayed Cerebral Ischemia-More in Common Than First Meets the Eye.", "authors": [{"family": "Bhogal", "given": "Pervinder", "initials": "P"}, {"family": "Makalanda", "given": "Levansri", "initials": "L", "orcid": "0000-0001-6637-9293", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e57d3cb6d01c4a3d96234e31e2f471a1.json"}}, {"family": "Hassan", "given": "Ameer E", "initials": "AE", "orcid": "0000-0002-7148-7616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f5948193707428eac79c94a082dc3a9.json"}}, {"family": "Fiorella", "given": "Dave", "initials": "D"}, {"family": "Andersson", "given": "Tommy", "initials": "T", "orcid": "0000-0001-8202-7829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec80cd01fb984f2c927728d554f3d220.json"}}, {"family": "Ahmad", "given": "Muhammad", "initials": "M"}, {"family": "B\u00e4zner", "given": "Hansj\u00f6rg", "initials": "H"}, {"family": "Jaffer", "given": "Ounali", "initials": "O"}, {"family": "Henkes", "given": "Hans", "initials": "H", "orcid": "0000-0002-6534-036X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a14520c05674ca4aba1925525002829.json"}}], "type": "journal article", "published": "2021-06-16", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "10", "issue": "12", "issn-l": "2077-0383"}, "abstract": "Since the arrival of the global COVID-19 pandemic scientists around the world have been working to understand the pathological mechanisms resulting from infection. There has gradually been an understanding that COVID-19 triggers a widespread endotheliopathy and that this can result in a widespread thrombosis and in particular a microthrombosis. The mechanisms involved in the microthrombosis are not confined to infection and there is evidence that patients with aneurysmal sub-arachnoid haemorrhage (SAH) also suffer from an endotheliopathy and microthrombosis. In this article we attempt to shed light on similarities in the underlying processes involved in both diseases and suggest potential treatment options.", "doi": "10.3390/jcm10122646", "pmid": "34208470", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jcm10122646"}], "notes": [], "created": "2021-07-05T14:44:28.293Z", "modified": "2021-07-05T14:56:22.840Z"}, {"entity": "publication", "iuid": "875647dd80d9464088d6306cf0bccf64", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/875647dd80d9464088d6306cf0bccf64.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/875647dd80d9464088d6306cf0bccf64"}}, "title": "A novel automated SARS-CoV-2 saliva PCR test protects a global asymptomatic workforce.", "authors": [{"family": "Carter", "given": "Nikki", "initials": "N"}, {"family": "Clausen", "given": "Maryam", "initials": "M"}, {"family": "Halpin", "given": "Rebecca A", "initials": "RA"}, {"family": "Blackmore", "given": "Colin", "initials": "C"}, {"family": "Cai", "given": "Kang", "initials": "K"}, {"family": "Delpuech", "given": "Oona", "initials": "O"}, {"family": "Kohlmann", "given": "Alexander", "initials": "A"}, {"family": "Magnusson", "given": "Otto", "initials": "O"}, {"family": "March", "given": "Ruth", "initials": "R"}, {"family": "O'Neill", "given": "Daniel", "initials": "D"}, {"family": "Prakash", "given": "Kasthuri", "initials": "K"}, {"family": "Sherwood", "given": "James", "initials": "J"}, {"family": "Sundin", "given": "Tabetha", "initials": "T"}, {"family": "Swift", "given": "Jason", "initials": "J"}, {"family": "Tarakameh", "given": "Azar", "initials": "A"}, {"family": "Wijdicks", "given": "Marilou", "initials": "M"}, {"family": "Wise", "given": "Daniel", "initials": "D"}, {"family": "Fidock", "given": "Mark", "initials": "M"}], "type": "journal article", "published": "2021-06-16", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "12676"}, "abstract": "Regular PCR testing of nasopharyngeal swabs from symptomatic individuals for SARS-CoV-2 virus has become the established method by which health services are managing the COVID-19 pandemic. Businesses such as AstraZeneca have also prioritised voluntary asymptomatic testing to keep workplaces safe and maintain supply of essential medicines to patients. We describe the development of an internal automated SARS-CoV-2 testing programme including the transformative introduction of saliva as an alternative sample type.", "doi": "10.1038/s41598-021-92070-w", "pmid": "34135391", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-92070-w"}, {"db": "pmc", "key": "PMC8209156"}], "notes": [], "created": "2021-06-28T18:42:21.621Z", "modified": "2021-06-30T05:10:06.409Z"}, {"entity": "publication", "iuid": "3964c56151144b969fd3dbc05ed3069c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3964c56151144b969fd3dbc05ed3069c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3964c56151144b969fd3dbc05ed3069c"}}, "title": "SARS-CoV-2 Spike protein binding of glycated serum albumin - its potential role in the pathogenesis of the COVID-19 clinical syndromes and bias towards individuals with pre-diabetes/type 2 diabetes &amp; metabolic diseases", "authors": [{"family": "IIes", "given": "Jason K", "initials": "JK"}, {"family": "Zmuidinaite", "given": "Raminta", "initials": "R", "orcid": "0000-0001-7728-6623", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/421ae7d6575445888ac6bb7f537b4b16.json"}}, {"family": "Sadee", "given": "Christoph", "initials": "C"}, {"family": "Gardiner", "given": "Anna", "initials": "A"}, {"family": "Lacey", "given": "Jonathan", "initials": "J"}, {"family": "Harding", "given": "Stephen", "initials": "S"}, {"family": "Ule", "given": "Jernej", "initials": "J", "orcid": "0000-0002-2452-4277", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df39ffa7b830405ba54b42987ad9c0cc.json"}}, {"family": "Roblett", "given": "Debra", "initials": "D"}, {"family": "Iles", "given": "Ray K", "initials": "RK", "orcid": "0000-0003-0573-9739", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b815fcd924e64abcaa064fc3482f114f.json"}}], "type": "posted-content", "published": "2021-06-15", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.06.14.21258871", "pmid": null, "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-06-17T07:50:07.080Z", "modified": "2023-06-19T14:18:51.180Z"}, {"entity": "publication", "iuid": "3cedafdf25154a119a7554bb9b330128", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3cedafdf25154a119a7554bb9b330128.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3cedafdf25154a119a7554bb9b330128"}}, "title": "Public acceptance of COVID-19 vaccines: cross-national evidence on levels and individual-level predictors using observational data.", "authors": [{"family": "Lindholt", "given": "Marie Fly", "initials": "MF", "orcid": "0000-0002-8044-2559", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5117f1c9ca11402387d5d5994c8e358a.json"}}, {"family": "J\u00f8rgensen", "given": "Frederik", "initials": "F"}, {"family": "Bor", "given": "Alexander", "initials": "A"}, {"family": "Petersen", "given": "Michael Bang", "initials": "MB"}], "type": "journal article", "published": "2021-06-15", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "6", "pages": "e048172"}, "abstract": "The management of the COVID-19 pandemic hinges on the approval of safe and effective vaccines but, equally importantly, on high vaccine acceptance among people. To facilitate vaccine acceptance via effective health communication, it is key to understand levels of vaccine scepticism and the demographic, psychological and political predictors. To this end, we examine the levels and predictors of acceptance of an approved COVID-19 vaccine.\n\nWe examine the levels and predictors of acceptance of an approved COVID-19 vaccine in large online surveys from eight Western democracies that differ in terms of the severity of the pandemic and their response: Denmark, France, Germany, Hungary, Sweden, Italy, UK and USA (total N=18 231). Survey respondents were quota sampled to match the population margins on age, gender and geographical location for each country. The study was conducted from September 2020 to February 2021, allowing us to assess changes in acceptance and predictors as COVID-19 vaccine programmes were rolled out.\n\nThe outcome of the study is self-reported acceptance of a COVID-19 vaccine approved and recommended by health authorities.\n\nThe data reveal large variations in vaccine acceptance that ranges from 83% in Denmark to 47% in France and Hungary. Lack of vaccine acceptance is associated with lack of trust in authorities and scientists, conspiratorial thinking and a lack of concern about COVID-19.\n\nMost national levels of vaccine acceptance fall below estimates of the required threshold for herd immunity. The results emphasise the long-term importance of building trust in preparations for health emergencies such as the current pandemic. For health communication, the results emphasise the importance of focusing on personal consequences of infections and debunking of myths to guide communication strategies.", "doi": "10.1136/bmjopen-2020-048172", "pmid": "34130963", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8210695"}, {"db": "pii", "key": "bmjopen-2020-048172"}], "notes": [], "created": "2021-06-17T07:38:34.366Z", "modified": "2023-06-19T15:02:47.895Z"}, {"entity": "publication", "iuid": "a41604e113284f04ad764896bff28508", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a41604e113284f04ad764896bff28508.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a41604e113284f04ad764896bff28508"}}, "title": "Point of care detection of COVID-19: Advancement in biosensing and diagnostic methods.", "authors": [{"family": "Suleman", "given": "Shariq", "initials": "S"}, {"family": "Shukla", "given": "Sudheesh K", "initials": "SK"}, {"family": "Malhotra", "given": "Nitesh", "initials": "N"}, {"family": "Bukkitgar", "given": "Shikandar D", "initials": "SD"}, {"family": "Shetti", "given": "Nagaraj P", "initials": "NP"}, {"family": "Pilloton", "given": "Roberto", "initials": "R"}, {"family": "Narang", "given": "Jagriti", "initials": "J"}, {"family": "Nee Tan", "given": "Yen", "initials": "Y"}, {"family": "Aminabhavi", "given": "Tejraj M", "initials": "TM"}], "type": "journal article", "published": "2021-06-15", "journal": {"title": "Chem Eng J", "issn": "1385-8947", "volume": "414", "issue": null, "pages": "128759", "issn-l": null}, "abstract": "The recent outbreak of COVID-19 has created much inconvenience and fear that the virus can seriously affect humans, causing health hazards and death. This pandemic has created much worry and as per the report by World Health Organization (WHO), more than 43 million individuals in 215 countries and territories were affected. People around the world are still struggling to overcome the problems associated with this pandemic. Of all the available methods, reverse-transcriptase polymerase chain reaction (RT-PCR) has been widely practiced for the pandemic detection even though several diagnostic tools are available having varying accuracy and sensitivity. The method offers many advantages making it a life-saving tool, but the method has the limitation of transporting to the nearest pathology lab, thus limiting its application in resource limited settings. This has a risen a crucial need for point-of-care devices for on-site detection. In this venture, biosensors have been used, since they can be applied immediately at the point-of-care. This review will discuss about the available diagnostic methods and biosensors for COVID-19 detection.", "doi": "10.1016/j.cej.2021.128759", "pmid": "33551668", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1385-8947(21)00356-9"}, {"db": "pmc", "key": "PMC7847737"}], "notes": [], "created": "2021-02-10T18:50:48.806Z", "modified": "2021-02-10T18:50:48.828Z"}, {"entity": "publication", "iuid": "b93533b9d7704873b5fafccdffc467be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b93533b9d7704873b5fafccdffc467be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b93533b9d7704873b5fafccdffc467be"}}, "title": "Molecular determinants of disease severity in urinary tract infection.", "authors": [{"family": "Ambite", "given": "Ines", "initials": "I", "orcid": "0000-0003-1470-671X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b32089f6f4634bca8d1aa25dab3f1f1f.json"}}, {"family": "Butler", "given": "Daniel", "initials": "D", "orcid": "0000-0002-6717-545X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/091753e4d1ee46adaae712172033c21e.json"}}, {"family": "Wan", "given": "Murphy Lam Yim", "initials": "MLY"}, {"family": "Rosenblad", "given": "Therese", "initials": "T"}, {"family": "Tran", "given": "Thi Hien", "initials": "TH"}, {"family": "Chao", "given": "Sing Ming", "initials": "SM"}, {"family": "Svanborg", "given": "Catharina", "initials": "C"}], "type": "journal article", "published": "2021-06-15", "journal": {"title": "Nat Rev Urol", "issn": "1759-4820", "issn-l": null}, "abstract": "The most common and lethal bacterial pathogens have co-evolved with the host. Pathogens are the aggressors, and the host immune system is responsible for the defence. However, immune responses can also become destructive, and excessive innate immune activation is a major cause of infection-associated morbidity, exemplified by symptomatic urinary tract infections (UTIs), which are caused, in part, by excessive innate immune activation. Severe kidney infections (acute pyelonephritis) are a major cause of morbidity and mortality, and painful infections of the urinary bladder (acute cystitis) can become debilitating in susceptible patients. Disease severity is controlled at specific innate immune checkpoints, and a detailed understanding of their functions is crucial for strategies to counter microbial aggression with novel treatment and prevention measures. One approach is the use of bacterial molecules that reprogramme the innate immune system, accelerating or inhibiting disease processes. A very different outcome is asymptomatic bacteriuria, defined by low host immune responsiveness to bacteria with attenuated virulence. This observation provides the rationale for immunomodulation as a new therapeutic tool to deliberately modify host susceptibility, control the host response and avoid severe disease. The power of innate immunity as an arbitrator of health and disease is also highly relevant for emerging pathogens, including the current COVID-19 pandemic.", "doi": "10.1038/s41585-021-00477-x", "pmid": "34131331", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41585-021-00477-x"}], "notes": [], "created": "2021-06-17T07:36:27.229Z", "modified": "2021-06-17T07:36:40.244Z"}, {"entity": "publication", "iuid": "725d7eea1cf94a2db46c13223e5682a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/725d7eea1cf94a2db46c13223e5682a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/725d7eea1cf94a2db46c13223e5682a2"}}, "title": "Changes to household income in a Kenyan informal settlement during COVID-19", "authors": [{"family": "Tompsett", "given": "Anna", "initials": "A", "orcid": "0000-0002-5415-6583", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/780bff9b7f844676884c466b184933d1.json"}}, {"family": "Baum", "given": "Aaron", "initials": "A", "orcid": "0000-0003-4999-3480", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9df82e2e71604e7fbd3d3a38280ee2e9.json"}}, {"family": "Bukachi", "given": "Vera", "initials": "V", "orcid": "0000-0003-0448-1983", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a5c57d3aedd49d69e028bbe47b8b2f7.json"}}, {"family": "Kipkemboi", "given": "Pascal", "initials": "P"}, {"family": "K\u2019oyoo", "given": "Allan Ouko", "initials": "AO"}, {"family": "Varela", "given": "Ana Varela", "initials": "AV", "orcid": "0000-0003-1960-5619", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3604aec1e9445d18b4be865638d6cb1.json"}}, {"family": "Mulligan", "given": "Joseph", "initials": "J", "orcid": "0000-0002-8614-3787", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c4c96ea8f904b52b0d099c912511547.json"}}], "type": "posted-content", "published": "2021-06-15", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.06.15.21254693", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-06-17T07:51:05.519Z", "modified": "2023-06-19T14:11:58.638Z"}, {"entity": "publication", "iuid": "d94670e1580f4e05bc5b84b85be4eba7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d94670e1580f4e05bc5b84b85be4eba7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d94670e1580f4e05bc5b84b85be4eba7"}}, "title": "SARS-CoV-2 antigen testing: weighing the false positives against the costs of failing to control transmission.", "authors": [{"family": "Fearon", "given": "Elizabeth", "initials": "E"}, {"family": "Buchan", "given": "Iain E", "initials": "IE"}, {"family": "Das", "given": "Rajenki", "initials": "R"}, {"family": "Davis", "given": "Emma L", "initials": "EL"}, {"family": "Fyles", "given": "Martyn", "initials": "M"}, {"family": "Hall", "given": "Ian", "initials": "I"}, {"family": "Hollingsworth", "given": "T Deirdre", "initials": "TD"}, {"family": "House", "given": "Thomas", "initials": "T"}, {"family": "Jay", "given": "Caroline", "initials": "C"}, {"family": "Medley", "given": "Graham F", "initials": "GF"}, {"family": "Pellis", "given": "Lorenzo", "initials": "L"}, {"family": "Quilty", "given": "Billy J", "initials": "BJ"}, {"family": "Silva", "given": "Miguel E P", "initials": "MEP"}, {"family": "Stage", "given": "Helena B", "initials": "HB"}, {"family": "Wingfield", "given": "Tom", "initials": "T"}], "type": "journal article", "published": "2021-06-14", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "issn-l": "2213-2600", "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/S2213-2600(21)00234-4", "pmid": "34139150", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Proteins": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(21)00234-4"}, {"db": "pmc", "key": "PMC8203180"}], "notes": [], "created": "2021-06-28T18:38:00.383Z", "modified": "2021-06-28T18:38:15.256Z"}, {"entity": "publication", "iuid": "83359ec64ced454083ee5d1daa70968e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/83359ec64ced454083ee5d1daa70968e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/83359ec64ced454083ee5d1daa70968e"}}, "title": "Quality of web-based information at the beginning of a global pandemic: a cross-sectional infodemiology study investigating preventive measures and self care methods of the coronavirus disease 2019.", "authors": [{"family": "Stern", "given": "Jenny", "initials": "J"}, {"family": "Georgsson", "given": "Susanne", "initials": "S"}, {"family": "Carlsson", "given": "Tommy", "initials": "T"}], "type": "journal article", "published": "2021-06-14", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "1141"}, "abstract": "reducing the spread and impact epidemics and pandemics requires that members of the general population change their behaviors according to the recommendations, restrictions and laws provided by leading authorities. When a new epidemic or pandemic emerges, people are faced with the challenge of sorting through a great volume of varied information. Therefore, the dissemination of high-quality web-based information is essential during this time period. The overarching aim was to investigate the quality of web-based information about preventive measures and self care methods at the beginning of the COVID-19 pandemic.\r\n\r\nin May 2020, consumer-oriented websites written in Swedish were identified via systematic searches in Google (n = 76). Websites were assessed with inductive content analysis, the JAMA benchmarks, the QUEST tool and the DISCERN instrument.\r\n\r\nseven categories and 33 subcategories were identified concerning preventive measures (md = 6.0 subcategories), with few specifying a method for washing hands (n = 4), when to sanitize the hands (n = 4), and a method for sanitizing the hands (n = 1). Eight categories and 30 subcategories were identified concerning self care methods (md = 3.0 subcategories), with few referring to the national number for telephone-based counseling (n = 20) and an online symptom assessment tool (n = 16). Overall, the median total quality scores were low (JAMA = 0/4, QUEST =13/28, DISCERN = 29/80).\r\n\r\nat the beginning of the pandemic, substantial quality deficits of websites about COVID-19 may have counteracted the public recommendations for preventive measures. This illustrates a critical need for standardized and systematic routines on how to achieve dissemination of high-quality web-based information when new epidemics and pandemics emerge.", "doi": "10.1186/s12889-021-11141-9", "pmid": "34126962", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11141-9"}], "notes": [], "created": "2021-06-17T07:45:13.842Z", "modified": "2021-07-14T10:43:17.935Z"}, {"entity": "publication", "iuid": "6a76f804003d4811a92d215d7bebb1d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a76f804003d4811a92d215d7bebb1d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a76f804003d4811a92d215d7bebb1d7"}}, "title": "Internet-Based Cognitive Behavioral Therapy for Psychological Distress Associated With the COVID-19 Pandemic: A Pilot Randomized Controlled Trial.", "authors": [{"family": "Aminoff", "given": "Victoria", "initials": "V"}, {"family": "Sell\u00e9n", "given": "Malin", "initials": "M"}, {"family": "S\u00f6rliden", "given": "Elise", "initials": "E"}, {"family": "Ludvigsson", "given": "Mikael", "initials": "M"}, {"family": "Berg", "given": "Matilda", "initials": "M"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}], "type": "journal article", "published": "2021-06-14", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "684540", "issn-l": "1664-1078"}, "abstract": "Background: The COVID-19 pandemic has been associated with various negative psychological consequences. This is a challenge for the society as regular psychological services cannot be offered to the same extent as before the pandemic. In addition to the requirement of social distancing, there is a need to adjust psychological treatment components like exposure to avoid increasing the spread of the infection. Internet-delivered cognitive behavior therapy (ICBT) has an established evidence base for a range of psychiatric problems and has been suggested as one possible approach to deal with the situation. This study aimed to conduct a randomized controlled pilot trial during the summer of 2020 with a broad focus on psychological distress and a treatment approach that tailors the intervention based on symptom profile and preferences. Methods: Following the advertisement and interview, we included 52 participants with elevated levels of psychological distress. They were randomly allocated to either a 7-week-long individually tailored ICBT (n = 26) or a wait-list control condition (n = 26). Measures of depression and quality of life were used as primary outcomes. We also included secondary outcome measures of anxiety, insomnia, trauma, stress, anger, and alcohol use. For screening, we used the CoRonavIruS Health Impact Survey (CRISIS). Results: Overall moderate to large between-group effects were found at post-treatment in favor of the treatment on measures of both depression [Beck Depression Inventory (BDI); Cohens d = 0.63; Patient Health Questionnaire (PHQ-9): d = 0.62] and anxiety [Generalized Anxiety Disorder-7-item scale (GAD-7); d = 0.82]. This was also observed for stress symptoms [Perceived Stress Scale (PSS-14); d = 1.04]. No effects were seen on measures of quality of life, insomnia, symptoms of post-traumatic stress, and anger. There was an effect on alcohol use [Alcohol Use Disorder Identification Test (AUDIT); d = 0.54], which was not of clinical relevance. Conclusion: Individually tailored ICBT shows initial promise as a way to reduce psychological problems in association with the COVID-19 pandemic. A possible limitation was that the trial was conducted when the effects of the pandemic were decreasing and when fewer people were affected by the restrictions (e.g., the summer of 2020).", "doi": "10.3389/fpsyg.2021.684540", "pmid": "34194374", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8236879"}], "notes": [], "created": "2021-07-05T14:30:27.245Z", "modified": "2021-07-05T14:30:27.258Z"}, {"entity": "publication", "iuid": "66daaaac6fb74d54bbdeb2514441f642", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66daaaac6fb74d54bbdeb2514441f642.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66daaaac6fb74d54bbdeb2514441f642"}}, "title": "Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19: the PROFLO multicenter randomized clinical trial.", "authors": [{"family": "Ros\u00e9n", "given": "Jacob", "initials": "J", "orcid": "0000-0001-9518-5834", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ce3d5b2cb914d72bbd476b7e1127c8d.json"}}, {"family": "von Oelreich", "given": "Erik", "initials": "E"}, {"family": "Fors", "given": "Diddi", "initials": "D"}, {"family": "Jonsson Fagerlund", "given": "Malin", "initials": "M"}, {"family": "Taxbro", "given": "Knut", "initials": "K"}, {"family": "Skorup", "given": "Paul", "initials": "P"}, {"family": "Eby", "given": "Ludvig", "initials": "L"}, {"family": "Campoccia Jalde", "given": "Francesca", "initials": "F"}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Bergstr\u00f6m", "given": "Gustav", "initials": "G"}, {"family": "Frykholm", "given": "Peter", "initials": "P"}, {"family": "PROFLO Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-06-14", "journal": {"title": "Crit Care", "issn": "1466-609X", "volume": "25", "issue": "1", "pages": "209", "issn-l": "1364-8535"}, "abstract": "The effect of awake prone positioning on intubation rates is not established. The aim of this trial was to investigate if a protocol for awake prone positioning reduces the rate of endotracheal intubation compared with standard care among patients with moderate to severe hypoxemic respiratory failure due to COVID-19.\n\nWe conducted a multicenter randomized clinical trial. Adult patients with confirmed COVID-19, high-flow nasal oxygen or noninvasive ventilation for respiratory support and a PaO 2/FiO2 ratio \u2264 20 kPa were randomly assigned to a protocol targeting 16 h prone positioning per day or standard care. The primary endpoint was intubation within 30 days. Secondary endpoints included duration of awake prone positioning, 30-day mortality, ventilator-free days, hospital and intensive care unit length of stay, use of noninvasive ventilation, organ support and adverse events. The trial was terminated early due to futility.\n\nOf 141 patients assessed for eligibility, 75 were randomized of whom 39 were allocated to the control group and 36 to the prone group. Within 30 days after enrollment, 13 patients (33%) were intubated in the control group versus 12 patients (33%) in the prone group (HR 1.01 (95% CI 0.46-2.21), P = 0.99). Median prone duration was 3.4 h [IQR 1.8-8.4] in the control group compared with 9.0 h per day [IQR 4.4-10.6] in the prone group (P = 0.014). Nine patients (23%) in the control group had pressure sores compared with two patients (6%) in the prone group (difference - 18% (95% CI - 2 to - 33%); P = 0.032). There were no other differences in secondary outcomes between groups.\n\nThe implemented protocol for awake prone positioning increased duration of prone positioning, but did not reduce the rate of intubation in patients with hypoxemic respiratory failure due to COVID-19 compared to standard care.\n\nISRCTN54917435. Registered 15 June 2020 ( https://doi.org/10.1186/ISRCTN54917435 ).", "doi": "10.1186/s13054-021-03602-9", "pmid": "34127046", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-021-03602-9"}], "notes": [], "created": "2021-06-17T07:46:39.730Z", "modified": "2021-06-17T07:46:39.756Z"}, {"entity": "publication", "iuid": "fd6568a926674a8cb267ba9af3f57b03", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fd6568a926674a8cb267ba9af3f57b03.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fd6568a926674a8cb267ba9af3f57b03"}}, "title": "A time-resolved proteomic and prognostic map of COVID-19.", "authors": [{"family": "Demichev", "given": "Vadim", "initials": "V"}, {"family": "Tober-Lau", "given": "Pinkus", "initials": "P"}, {"family": "Lemke", "given": "Oliver", "initials": "O"}, {"family": "Nazarenko", "given": "Tatiana", "initials": "T"}, {"family": "Thibeault", "given": "Charlotte", "initials": "C"}, {"family": "Whitwell", "given": "Harry", "initials": "H"}, {"family": "R\u00f6hl", "given": "Annika", "initials": "A"}, {"family": "Freiwald", "given": "Anja", "initials": "A"}, {"family": "Szyrwiel", "given": "Lukasz", "initials": "L"}, {"family": "Ludwig", "given": "Daniela", "initials": "D"}, {"family": "Correia-Melo", "given": "Clara", "initials": "C"}, {"family": "Aulakh", "given": "Simran Kaur", "initials": "SK"}, {"family": "Helbig", "given": "Elisa T", "initials": "ET"}, {"family": "Stubbemann", "given": "Paula", "initials": "P"}, {"family": "Lippert", "given": "Lena J", "initials": "LJ"}, {"family": "Gr\u00fcning", "given": "Nana-Maria", "initials": "N"}, {"family": "Blyuss", "given": "Oleg", "initials": "O"}, {"family": "Vernardis", "given": "Spyros", "initials": "S"}, {"family": "White", "given": "Matthew", "initials": "M"}, {"family": "Messner", "given": "Christoph B", "initials": "CB"}, {"family": "Joannidis", "given": "Michael", "initials": "M"}, {"family": "Sonnweber", "given": "Thomas", "initials": "T"}, {"family": "Klein", "given": "Sebastian J", "initials": "SJ"}, {"family": "Pizzini", "given": "Alex", "initials": "A"}, {"family": "Wohlfarter", "given": "Yvonne", "initials": "Y"}, {"family": "Sahanic", "given": "Sabina", "initials": "S"}, {"family": "Hilbe", "given": "Richard", "initials": "R"}, {"family": "Schaefer", "given": "Benedikt", "initials": "B"}, {"family": "Wagner", "given": "Sonja", "initials": "S"}, {"family": "Mittermaier", "given": "Mirja", "initials": "M"}, {"family": "Machleidt", "given": "Felix", "initials": "F"}, {"family": "Garcia", "given": "Carmen", "initials": "C"}, {"family": "Ruwwe-Gl\u00f6senkamp", "given": "Christoph", "initials": "C"}, {"family": "Lingscheid", "given": "Tilman", "initials": "T"}, {"family": "Bosquillon de Jarcy", "given": "Laure", "initials": "L"}, {"family": "Stegemann", "given": "Miriam S", "initials": "MS"}, {"family": "Pfeiffer", "given": "Moritz", "initials": "M"}, {"family": "J\u00fcrgens", "given": "Linda", "initials": "L"}, {"family": "Denker", "given": "Sophy", "initials": "S"}, {"family": "Zickler", "given": "Daniel", "initials": "D"}, {"family": "Enghard", "given": "Philipp", "initials": "P"}, {"family": "Zelezniak", "given": "Aleksej", "initials": "A"}, {"family": "Campbell", "given": "Archie", "initials": "A"}, {"family": "Hayward", "given": "Caroline", "initials": "C"}, {"family": "Porteous", "given": "David J", "initials": "DJ"}, {"family": "Marioni", "given": "Riccardo E", "initials": "RE"}, {"family": "Uhrig", "given": "Alexander", "initials": "A"}, {"family": "M\u00fcller-Redetzky", "given": "Holger", "initials": "H"}, {"family": "Zoller", "given": "Heinz", "initials": "H"}, {"family": "L\u00f6ffler-Ragg", "given": "Judith", "initials": "J"}, {"family": "Keller", "given": "Markus A", "initials": "MA"}, {"family": "Tancevski", "given": "Ivan", "initials": "I"}, {"family": "Timms", "given": "John F", "initials": "JF"}, {"family": "Zaikin", "given": "Alexey", "initials": "A"}, {"family": "Hippenstiel", "given": "Stefan", "initials": "S"}, {"family": "Ramharter", "given": "Michael", "initials": "M"}, {"family": "Witzenrath", "given": "Martin", "initials": "M"}, {"family": "Suttorp", "given": "Norbert", "initials": "N"}, {"family": "Lilley", "given": "Kathryn", "initials": "K"}, {"family": "M\u00fclleder", "given": "Michael", "initials": "M"}, {"family": "Sander", "given": "Leif Erik", "initials": "LE"}, {"family": "PA-COVID-19 Study group", "given": "", "initials": ""}, {"family": "Ralser", "given": "Markus", "initials": "M"}, {"family": "Kurth", "given": "Florian", "initials": "F"}], "type": "journal article", "published": "2021-06-14", "journal": {"title": "Cell Syst", "issn": "2405-4720", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. We characterized the time-dependent progression of the disease in 139 COVID-19 inpatients by measuring 86 accredited diagnostic parameters, such as blood cell counts and enzyme activities, as well as untargeted plasma proteomes at 687 sampling points. We report an initial spike in a systemic inflammatory response, which is gradually alleviated and followed by a protein signature indicative of tissue repair, metabolic reconstitution, and immunomodulation. We identify prognostic marker signatures for devising risk-adapted treatment strategies and use machine learning to classify therapeutic needs. We show that the machine learning models based on the proteome are transferable to an independent cohort. Our study presents a map linking routinely used clinical diagnostic parameters to plasma proteomes and their dynamics in an infectious disease.", "doi": "10.1016/j.cels.2021.05.005", "pmid": "34139154", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S2405-4712(21)00160-5"}, {"db": "pmc", "key": "PMC8201874"}], "notes": [], "created": "2021-06-28T18:35:54.366Z", "modified": "2021-06-30T05:12:43.763Z"}, {"entity": "publication", "iuid": "18f851e21f6d4ea4b5bd88550870048c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18f851e21f6d4ea4b5bd88550870048c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18f851e21f6d4ea4b5bd88550870048c"}}, "title": "SARS-CoV-2 spike protein removes lipids from model membranes and interferes with the capacity of high density lipoprotein to exchange lipids.", "authors": [{"family": "Correa", "given": "Yubexi", "initials": "Y"}, {"family": "Waldie", "given": "Sarah", "initials": "S"}, {"family": "Th\u00e9paut", "given": "Michel", "initials": "M"}, {"family": "Micciula", "given": "Samantha", "initials": "S"}, {"family": "Moulin", "given": "Martine", "initials": "M"}, {"family": "Fieschi", "given": "Franck", "initials": "F"}, {"family": "Pichler", "given": "Harald", "initials": "H"}, {"family": "Trevor Forsyth", "given": "V", "initials": "V"}, {"family": "Haertlein", "given": "Michael", "initials": "M"}, {"family": "C\u00e1rdenas", "given": "Marit\u00e9", "initials": "M"}], "type": "journal article", "published": "2021-06-12", "journal": {"title": "J Colloid Interface Sci", "issn": "1095-7103", "issn-l": null, "volume": "602", "issue": null, "pages": "732-739"}, "abstract": "Cholesterol has been shown to affect the extent of coronavirus binding and fusion to cellular membranes. The severity of Covid-19 infection is also known to be correlated with lipid disorders. Furthermore, the levels of both serum cholesterol and high-density lipoprotein (HDL) decrease with Covid-19 severity, with normal levels resuming once the infection has passed. Here we demonstrate that the SARS-CoV-2 spike (S) protein interferes with the function of lipoproteins, and that this is dependent on cholesterol. In particular, the ability of HDL to exchange lipids from model cellular membranes is altered when co-incubated with the spike protein. Additionally, the S protein removes lipids and cholesterol from model membranes. We propose that the S protein affects HDL function by removing lipids from it and remodelling its composition/structure.", "doi": "10.1016/j.jcis.2021.06.056", "pmid": "34157514", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S0021-9797(21)00930-9"}, {"db": "pmc", "key": "PMC8195693"}], "notes": [], "created": "2021-06-28T18:20:09.531Z", "modified": "2021-06-28T18:21:11.283Z"}, {"entity": "publication", "iuid": "e88362b5f2fc485c865d6d25f77f54cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e88362b5f2fc485c865d6d25f77f54cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e88362b5f2fc485c865d6d25f77f54cc"}}, "title": "Decreased Mortality Over Time During the First Wave in Patients With COVID-19 in Geriatric Care: Data From the Stockholm GeroCovid Study.", "authors": [{"family": "Xu", "given": "Hong", "initials": "H"}, {"family": "Garcia-Ptacek", "given": "Sara", "initials": "S"}, {"family": "Annetorp", "given": "Martin", "initials": "M"}, {"family": "Cederholm", "given": "Tommy", "initials": "T"}, {"family": "Engel", "given": "Georg", "initials": "G"}, {"family": "Engstr\u00f6m", "given": "Malin", "initials": "M"}, {"family": "Erlandsson", "given": "H\u00e5kan", "initials": "H"}, {"family": "Julius", "given": "Charlotte", "initials": "C"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Lundberg", "given": "Lars G\u00f6ran", "initials": "LG"}, {"family": "Metzner", "given": "Carina", "initials": "C"}, {"family": "Sandberg", "given": "Linda", "initials": "L"}, {"family": "Nyvang", "given": "Josefina Skog\u00f6", "initials": "JS"}, {"family": "\u00d6berg", "given": "Carina S\u00fchl", "initials": "CS"}, {"family": "\u00c5kesson", "given": "Elisabet", "initials": "E"}, {"family": "Religa", "given": "Dorota", "initials": "D"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-06-12", "journal": {"title": "J Am Med Dir Assoc", "issn": "1538-9375", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To describe temporal changes in treatment, care, and short-term mortality outcomes of geriatric patients during the first wave of the COVID-19 pandemic.\r\n\r\nObservational study.\r\n\r\nAltogether 1785 patients diagnosed with COVID-19 and 6744 hospitalized for non-COVID-19 causes at 7 geriatric clinics in Stockholm from March 6 to July 31, 2020, were included.\r\n\r\nAcross admission month, patient vital signs and pharmacological treatment in relationship to risk for in-hospital death were analyzed using the Poisson regression model. Incidence rates (IRs) and incidence rate ratios (IRRs) of death are presented.\r\n\r\nIn patients with COVID-19, the IR of mortality were 27%, 17%, 10%, 8%, and 2% from March to July, respectively, after standardization for demographics and vital signs. Compared with patients admitted in March, the risk of in-hospital death decreased by 29% [IRR 0.71, 95% confidence interval (CI) 0.51-0.99] in April, 61% (0.39, 0.26-0.58) in May, 68% (0.32, 0.19-0.55) in June, and 86% (0.14, 0.03-0.58) in July. The proportion of patients admitted for geriatric care with oxygen saturation <90% decreased from 13% to 1%, which partly explains the improvement of COVID-19 patient survival. In non-COVID-19 patients during the pandemic, mortality rates remained relatively stable (IR 1.3%-2.3%). Compared with non-COVID-19 geriatric patients, the IRR of death declined from 11 times higher (IRR 11.7, 95% CI 6.11-22.3) to 1.6 times (2.61, 0.50-13.7) between March and July in patients with COVID-19.\r\n\r\nMortality risk in geriatric patients from the Stockholm region declined over time throughout the first pandemic wave of COVID-19. The improved survival rate over time was only partly related to improvement in saturation status at the admission of the patients hospitalized later throughout the pandemic. Lower incidence during the later months could have led to less severe hospitalized cases driving down mortality.", "doi": "10.1016/j.jamda.2021.06.005", "pmid": "34216553", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1525-8610(21)00554-5"}], "notes": [], "created": "2021-07-05T15:02:15.808Z", "modified": "2021-07-14T10:42:45.179Z"}, {"entity": "publication", "iuid": "10fa73a458484d42bf0e15088c099fb3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/10fa73a458484d42bf0e15088c099fb3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/10fa73a458484d42bf0e15088c099fb3"}}, "title": "Consequences of visiting restrictions during the COVID-19 pandemic: An integrative review.", "authors": [{"family": "Hugelius", "given": "Karin", "initials": "K"}, {"family": "Harada", "given": "Nahoko", "initials": "N"}, {"family": "Marutani", "given": "Miki", "initials": "M"}], "type": "journal article", "published": "2021-06-12", "journal": {"title": "Int J Nurs Stud", "issn": "1873-491X", "volume": "121", "pages": "104000", "issn-l": null}, "abstract": "During the COVID-19 pandemic, visiting restrictions of different extents have been implemented. However, despite the long history of visiting restrictions in health care systems, little is known about their effects.\n\nThis review sought to explore the consequences of visitor restrictions in health care services during the COVID-19 pandemic.\n\nA systematic, integrative review was conducted in accordance with the PRISMA guidelines, based on a systematic search in PubMed, CHINAL full plus, Web of Science, PsychInfo, Scopus and the Cochrane Library.\n\nA total of 17 scientific papers covering intensive care, pediatric care, general medical care, hospital care, palliative care and nursing home settings were included. Although appreciation for the technical solutions enabling remote meetings was reported, visiting restrictions had several consequences, mainly negative, for the patient's health, the health and wellbeing of family members and the provision of care. Among physical health consequences, reduced nutrition intake, decreased activities of daily living and increased physical pain and symptoms were reported. Among mental health consequences for the patient, loneliness, depressive symptoms, agitation, aggression, reduced cognitive ability and overall dissatisfaction were observed. For family members, worry, anxiety and uncertainty occurred, and they reported an increased need for information from care providers. Family members of neonatal intensive care unit patients reported less bonding with their child and family relation disturbances due to the restrictions. For care providers, visiting restrictions added the burdens of ethical dilemmas, learning new technical means to enable social interaction and an increased demand for communication with families and providing social support to both family members and patients.\n\nWhen implementing visiting restrictions in health care services, decision makers and nurses need to be aware of their potential negative effects and adapt the provision of care to compensate for such effects. Nurses in all sectors should be aware that visiting restrictions may affect patients, families, and health care services for longer than the actual pandemic. Since the level of evidence regarding effect from visiting restrictions is low, further studies is strongly needed.", "doi": "10.1016/j.ijnurstu.2021.104000", "pmid": "34242976", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0020-7489(21)00147-4"}, {"db": "pmc", "key": "PMC8196532"}], "notes": [], "created": "2021-08-06T07:57:55.486Z", "modified": "2021-08-06T07:57:55.509Z"}, {"entity": "publication", "iuid": "a4b68701383d467f979b00c17c6ae119", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a4b68701383d467f979b00c17c6ae119.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a4b68701383d467f979b00c17c6ae119"}}, "title": "Profiling Human CMV-specific T cell responses reveals novel immunogenic ORFs", "authors": [{"family": "Dhanwani", "given": "Rekha", "initials": "R", "orcid": "0000-0002-6592-8657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d61c1971458d49e0888b29976e0a3893.json"}}, {"family": "Dhanda", "given": "Sandeep Kumar", "initials": "SK"}, {"family": "Pham", "given": "John", "initials": "J"}, {"family": "Williams", "given": "Gregory P", "initials": "GP"}, {"family": "Sidney", "given": "John", "initials": "J"}, {"family": "Grifoni", "given": "Alba", "initials": "A", "orcid": "0000-0002-2209-5966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2cbbaebec64e41289979d55aed0b0ad4.json"}}, {"family": "Picarda", "given": "Gaelle", "initials": "G"}, {"family": "Lindestam Arlehamn", "given": "Cecilia S", "initials": "CS"}, {"family": "Sette", "given": "Alessandro", "initials": "A"}, {"family": "Benedict", "given": "Chris A", "initials": "CA"}], "type": "posted-content", "published": "2021-06-11", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.06.10.447997", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-06-14T14:52:49.944Z", "modified": "2023-06-19T15:22:57.372Z"}, {"entity": "publication", "iuid": "bfa777673501494b873a86821c2f9a30", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bfa777673501494b873a86821c2f9a30.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bfa777673501494b873a86821c2f9a30"}}, "title": "Natural killer cells in antiviral immunity.", "authors": [{"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Strunz", "given": "Benedikt", "initials": "B"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}], "type": "journal article", "published": "2021-06-11", "journal": {"title": "Nat Rev Immunol", "issn": "1474-1741", "issn-l": "1474-1733", "volume": null, "issue": null, "pages": null}, "abstract": "Natural killer (NK) cells play an important role in innate immune responses to viral infections. Here, we review recent insights into the role of NK cells in viral infections, with particular emphasis on human studies. We first discuss NK cells in the context of acute viral infections, with flavivirus and influenza virus infections as examples. Questions related to activation of NK cells, homing to infected tissues and the role of tissue-resident NK cells in acute viral infections are also addressed. Next, we discuss NK cells in the context of chronic viral infections with hepatitis C virus and HIV-1. Also covered is the role of adaptive-like NK cell expansions as well as the appearance of CD56 - NK cells in the course of chronic infection. Specific emphasis is then placed in viral infections in patients with primary immunodeficiencies affecting NK cells. Not least, studies in this area have revealed an important role for NK cells in controlling several herpesvirus infections. Finally, we address new data with respect to the activation of NK cells and NK cell function in humans infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) giving rise to coronavirus disease 2019 (COVID-19).", "doi": "10.1038/s41577-021-00558-3", "pmid": "34117484", "labels": {"Type: Review": null, "Funder: H2020": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41577-021-00558-3"}], "notes": [], "created": "2021-06-14T06:31:09.794Z", "modified": "2021-06-14T06:32:50.189Z"}, {"entity": "publication", "iuid": "fa45de1635df45478ddcbcc3953153c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa45de1635df45478ddcbcc3953153c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa45de1635df45478ddcbcc3953153c5"}}, "title": "Mental Health of Refugees and Migrants during the COVID-19 Pandemic: The Role of Experienced Discrimination and Daily Stressors.", "authors": [{"family": "Spiritus-Beerden", "given": "Eva", "initials": "E", "orcid": "0000-0003-2312-8034", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/515f6b3d01664e988fefe0a5344ce7c9.json"}}, {"family": "Verelst", "given": "An", "initials": "A", "orcid": "0000-0002-7178-643X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbcb257027514818993b0318a7c513bf.json"}}, {"family": "Devlieger", "given": "Ines", "initials": "I"}, {"family": "Langer Primdahl", "given": "Nina", "initials": "N"}, {"family": "Botelho Guedes", "given": "F\u00e1bio", "initials": "F"}, {"family": "Chiarenza", "given": "Antonio", "initials": "A"}, {"family": "De Maesschalck", "given": "Stephanie", "initials": "S"}, {"family": "Durbeej", "given": "Natalie", "initials": "N"}, {"family": "Garrido", "given": "Roc\u00edo", "initials": "R", "orcid": "0000-0002-2238-0222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa02e7e75daf40c79c429493d506693b.json"}}, {"family": "Gaspar de Matos", "given": "Margarida", "initials": "M"}, {"family": "Ioannidi", "given": "Elisabeth", "initials": "E"}, {"family": "Murphy", "given": "Rebecca", "initials": "R"}, {"family": "Oulahal", "given": "Rachid", "initials": "R", "orcid": "0000-0002-9120-0512", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb7a43d0144541ad9598f666f28e0564.json"}}, {"family": "Osman", "given": "Fatumo", "initials": "F"}, {"family": "Padilla", "given": "Beatriz", "initials": "B"}, {"family": "Paloma", "given": "Virginia", "initials": "V", "orcid": "0000-0002-0707-1982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f9661fbebe54eb6971d4e2644d487cd.json"}}, {"family": "Shehadeh", "given": "Amer", "initials": "A"}, {"family": "Sturm", "given": "Gesine", "initials": "G"}, {"family": "van den Muijsenbergh", "given": "Maria", "initials": "M"}, {"family": "Vasilikou", "given": "Katerina", "initials": "K"}, {"family": "Watters", "given": "Charles", "initials": "C"}, {"family": "Willems", "given": "Sara", "initials": "S", "orcid": "0000-0002-6349-7785", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a066fe07ba24b948a9ad37dc2db7a8d.json"}}, {"family": "Skovdal", "given": "Morten", "initials": "M"}, {"family": "Derluyn", "given": "Ilse", "initials": "I"}], "type": "journal article", "published": "2021-06-11", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "12", "pages": "6354"}, "abstract": "The COVID-19 pandemic is a defining global health crisis of our time. While the impact of COVID-19, including its mental health impact, is increasingly being documented, there remain important gaps regarding the specific consequences of the pandemic on particular population groups, including refugees and migrants. This study aims to uncover the impact of the COVID-19 pandemic on the mental health of refugees and migrants worldwide, disentangling the possible role of social and daily stressors, i.e., experiences of discrimination and daily living conditions. Descriptive analysis and structural equation modeling were used to analyze the responses of N = 20,742 refugees and migrants on the self-reporting global ApartTogether survey. Survey findings indicated that the mental health of refugees and migrants during the COVID-19 pandemic was significantly impacted, particularly for certain subgroups, (i.e., insecure housing situation and residence status, older respondents, and females) who reported experiencing higher levels of increased discrimination and increases in daily life stressors. There is a need to recognize the detrimental mental health impact of the COVID-19 pandemic on particular refugee and migrant groups and to develop interventions that target their unique needs.", "doi": "10.3390/ijerph18126354", "pmid": "34208243", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8296172"}, {"db": "pii", "key": "ijerph18126354"}], "notes": [], "created": "2021-07-05T14:44:02.414Z", "modified": "2023-06-19T14:49:46.737Z"}, {"entity": "publication", "iuid": "3106c8dfdbef48e9a634dbdcc99c2b58", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3106c8dfdbef48e9a634dbdcc99c2b58.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3106c8dfdbef48e9a634dbdcc99c2b58"}}, "title": "Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection.", "authors": [{"family": "Koenecke", "given": "Allison", "initials": "A", "orcid": "0000-0002-6233-8256", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df3eeaa979c5401a9e335cc2de290ddd.json"}}, {"family": "Powell", "given": "Michael", "initials": "M", "orcid": "0000-0003-2749-3725", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8f4a79115a0471b9bcc099f3af2e4c7.json"}}, {"family": "Xiong", "given": "Ruoxuan", "initials": "R"}, {"family": "Shen", "given": "Zhu", "initials": "Z"}, {"family": "Fischer", "given": "Nicole", "initials": "N"}, {"family": "Huq", "given": "Sakibul", "initials": "S"}, {"family": "Khalafallah", "given": "Adham M", "initials": "AM"}, {"family": "Trevisan", "given": "Marco", "initials": "M"}, {"family": "Sparen", "given": "P\u00e4r", "initials": "P", "orcid": "0000-0002-5184-8971", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5f390813419444091c61e211c442c6f.json"}}, {"family": "Carrero", "given": "Juan J", "initials": "JJ"}, {"family": "Nishimura", "given": "Akihiko", "initials": "A"}, {"family": "Caffo", "given": "Brian", "initials": "B"}, {"family": "Stuart", "given": "Elizabeth A", "initials": "EA"}, {"family": "Bai", "given": "Renyuan", "initials": "R"}, {"family": "Staedtke", "given": "Verena", "initials": "V"}, {"family": "Thomas", "given": "David L", "initials": "DL"}, {"family": "Papadopoulos", "given": "Nickolas", "initials": "N"}, {"family": "Kinzler", "given": "Ken W", "initials": "KW"}, {"family": "Vogelstein", "given": "Bert", "initials": "B"}, {"family": "Zhou", "given": "Shibin", "initials": "S"}, {"family": "Bettegowda", "given": "Chetan", "initials": "C"}, {"family": "Konig", "given": "Maximilian F", "initials": "MF", "orcid": "0000-0001-5045-5255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41b9c2c9bca54637959496d449b5aa31.json"}}, {"family": "Mensh", "given": "Brett D", "initials": "BD"}, {"family": "Vogelstein", "given": "Joshua T", "initials": "JT", "orcid": "0000-0003-2487-6237", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb459c056f1f46c28961552ea5180972.json"}}, {"family": "Athey", "given": "Susan", "initials": "S"}], "type": "journal article", "published": "2021-06-11", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "10", "issn-l": null}, "abstract": "In severe viral pneumonia, including Coronavirus disease 2019 (COVID-19), the viral replication phase is often followed by hyperinflammation, which can lead to acute respiratory distress syndrome, multi-organ failure, and death. We previously demonstrated that alpha-1 adrenergic receptor (\u237a 1-AR) antagonists can prevent hyperinflammation and death in mice. Here, we conducted retrospective analyses in two cohorts of patients with acute respiratory distress (ARD, n = 18,547) and three cohorts with pneumonia (n = 400,907). Federated across two ARD cohorts, we find that patients exposed to \u237a1-AR antagonists, as compared to unexposed patients, had a 34% relative risk reduction for mechanical ventilation and death (OR = 0.70, p = 0.021). We replicated these methods on three pneumonia cohorts, all with similar effects on both outcomes. All results were robust to sensitivity analyses. These results highlight the urgent need for prospective trials testing whether prophylactic use of \u237a1-AR antagonists ameliorates lower respiratory tract infection-associated hyperinflammation and death, as observed in COVID-19.", "doi": "10.7554/eLife.61700", "pmid": "34114951", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "61700"}], "notes": [], "created": "2021-06-14T06:34:58.781Z", "modified": "2021-06-14T06:35:13.702Z"}, {"entity": "publication", "iuid": "d1b262f8c4874505b7bbf24f302fe1cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1b262f8c4874505b7bbf24f302fe1cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1b262f8c4874505b7bbf24f302fe1cc"}}, "title": "A Blueprint for High Affinity SARS-CoV-2 Mpro Inhibitors from Activity-Based Compound Library Screening Guided by Analysis of Protein Dynamics.", "authors": [{"family": "Gossen", "given": "Jonas", "initials": "J", "orcid": "0000-0002-0730-6796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f7e23c127404ca1bea9151bd20030a5.json"}}, {"family": "Albani", "given": "Simone", "initials": "S"}, {"family": "Hanke", "given": "Anton", "initials": "A"}, {"family": "Joseph", "given": "Benjamin P", "initials": "BP"}, {"family": "Bergh", "given": "Cathrine", "initials": "C"}, {"family": "Kuzikov", "given": "Maria", "initials": "M", "orcid": "0000-0001-8771-1865", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fcbffac44a748028611a74f2678d8f9.json"}}, {"family": "Costanzi", "given": "Elisa", "initials": "E"}, {"family": "Manelfi", "given": "Candida", "initials": "C"}, {"family": "Storici", "given": "Paola", "initials": "P"}, {"family": "Gribbon", "given": "Philip", "initials": "P"}, {"family": "Beccari", "given": "Andrea R", "initials": "AR"}, {"family": "Talarico", "given": "Carmine", "initials": "C"}, {"family": "Spyrakis", "given": "Francesca", "initials": "F", "orcid": "0000-0002-4016-227X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa1e7500ff8a4440bb7058bcf55c9e4d.json"}}, {"family": "Lindahl", "given": "Erik", "initials": "E"}, {"family": "Zaliani", "given": "Andrea", "initials": "A", "orcid": "0000-0002-1740-8390", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9e31a5fa26f4e69a0815d1443d3ffc9.json"}}, {"family": "Carloni", "given": "Paolo", "initials": "P", "orcid": "0000-0002-9010-0149", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0729cca0143c4847a104475ba5354f94.json"}}, {"family": "Wade", "given": "Rebecca C", "initials": "RC", "orcid": "0000-0001-5951-8670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b13317434734da2a15ec2d4ba4d421d.json"}}, {"family": "Musiani", "given": "Francesco", "initials": "F", "orcid": "0000-0003-0200-1712", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5e6a98e63ce4cbfaf5a3da8cc777485.json"}}, {"family": "Kokh", "given": "Daria B", "initials": "DB", "orcid": "0000-0002-4687-6572", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00f108ee7f4fa58625e61548fea8db.json"}}, {"family": "Rossetti", "given": "Giulia", "initials": "G", "orcid": "0000-0002-2032-4630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/901dadea04014dc88651e5a711325fa8.json"}}], "type": "journal article", "published": "2021-06-11", "journal": {"title": "ACS Pharmacol. Transl. Sci.", "issn": "2575-9108", "volume": "4", "issue": "3", "pages": "1079-1095", "issn-l": null}, "abstract": "The SARS-CoV-2 coronavirus outbreak continues to spread at a rapid rate worldwide. The main protease (Mpro) is an attractive target for anti-COVID-19 agents. Unexpected difficulties have been encountered in the design of specific inhibitors. Here, by analyzing an ensemble of \u223c30 000 SARS-CoV-2 Mpro conformations from crystallographic studies and molecular simulations, we show that small structural variations in the binding site dramatically impact ligand binding properties. Hence, traditional druggability indices fail to adequately discriminate between highly and poorly druggable conformations of the binding site. By performing \u223c200 virtual screenings of compound libraries on selected protein structures, we redefine the protein's druggability as the consensus chemical space arising from the multiple conformations of the binding site formed upon ligand binding. This procedure revealed a unique SARS-CoV-2 Mpro blueprint that led to a definition of a specific structure-based pharmacophore. The latter explains the poor transferability of potent SARS-CoV Mpro inhibitors to SARS-CoV-2 Mpro, despite the identical sequences of the active sites. Importantly, application of the pharmacophore predicted novel high affinity inhibitors of SARS-CoV-2 Mpro, that were validated by in vitro assays performed here and by a newly solved X-ray crystal structure. These results provide a strong basis for effective rational drug design campaigns against SARS-CoV-2 Mpro and a new computational approach to screen protein targets with malleable binding sites.", "doi": "10.1021/acsptsci.0c00215", "pmid": "34136757", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8009102"}], "notes": [], "created": "2021-06-28T18:41:25.728Z", "modified": "2021-07-06T09:01:14.453Z"}, {"entity": "publication", "iuid": "b6cac9c277864b59bfd7fa173087685b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b6cac9c277864b59bfd7fa173087685b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b6cac9c277864b59bfd7fa173087685b"}}, "title": "Self-Perceived Life Satisfaction during the First Wave of the COVID-19 Pandemic in Sweden: A Cross-Sectional Study.", "authors": [{"family": "Brog\u00e5rdh", "given": "Christina", "initials": "C", "orcid": "0000-0002-9249-9421", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12898e4072414c3ea7bd1fd6dc3be4d4.json"}}, {"family": "Hammarlund", "given": "Catharina Sj\u00f6dahl", "initials": "CS", "orcid": "0000-0001-6071-6922", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8a4960ca87043e3b465c63e9256c96f.json"}}, {"family": "Eek", "given": "Frida", "initials": "F"}, {"family": "Stigmar", "given": "Kjerstin", "initials": "K"}, {"family": "Lindgren", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-9910-0380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a15011595cd540e6aec99ce62a9b70a4.json"}}, {"family": "Schouenborg", "given": "Anna Trulsson", "initials": "AT"}, {"family": "Hansson", "given": "Eva Ekvall", "initials": "EE"}], "type": "journal article", "published": "2021-06-09", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "12", "pages": "6234"}, "abstract": "Currently, there is limited knowledge on how the Swedish strategy with more lenient public health restrictions during the COVID-19 pandemic has influenced people's life satisfaction. Here, we investigated self-reported life satisfaction during the first wave of the pandemic in Sweden, and perceived changes in life satisfaction in relation to various sociodemographic factors. A total of 1082 people (mean age 48 (SD 12.2); 82% women) responded to an online survey during autumn 2020 including the \"Life Satisfaction Questionnaire-11\". A majority (69%) were satisfied with life as a whole, and with other important life domains, with the exception of contact with friends and sexual life. An equal share reported that life as a whole had either deteriorated (28%) or improved (29%). Of those that perceived a deterioration, 95% considered it to be due to the pandemic. Regarding deteriorated satisfaction with life as a whole, higher odds were found in the following groups: having no children living at home; being middle aged; having other sources of income than being employed; and having a chronic disease. The Swedish strategy might have contributed to the high proportion of satisfied people. Those who perceived a deterioration in life satisfaction may, however, need attention from Swedish Welfare Authorities.", "doi": "10.3390/ijerph18126234", "pmid": "34207621", "labels": {"Category: Public Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8296066"}, {"db": "pii", "key": "ijerph18126234"}], "notes": [], "created": "2021-07-05T14:43:45.842Z", "modified": "2023-06-19T14:34:11.088Z"}, {"entity": "publication", "iuid": "5e62d79cca764b5b8326f8e1e1f71a28", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e62d79cca764b5b8326f8e1e1f71a28.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e62d79cca764b5b8326f8e1e1f71a28"}}, "title": "SARS-CoV-2 Variants of Interest and Concern naming scheme conducive for global discourse.", "authors": [{"family": "Konings", "given": "Frank", "initials": "F", "orcid": "0000-0003-0070-4457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6676f07da06e4af68d3613f829990251.json"}}, {"family": "Perkins", "given": "Mark D", "initials": "MD"}, {"family": "Kuhn", "given": "Jens H", "initials": "JH"}, {"family": "Pallen", "given": "Mark J", "initials": "MJ", "orcid": "0000-0003-1807-3657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62d797d8942c4121a70b1bd77a0d4e9e.json"}}, {"family": "Alm", "given": "Erik J", "initials": "EJ"}, {"family": "Archer", "given": "Brett N", "initials": "BN"}, {"family": "Barakat", "given": "Amal", "initials": "A"}, {"family": "Bedford", "given": "Trevor", "initials": "T"}, {"family": "Bhiman", "given": "Jinal N", "initials": "JN"}, {"family": "Caly", "given": "Leon", "initials": "L"}, {"family": "Carter", "given": "Lisa L", "initials": "LL"}, {"family": "Cullinane", "given": "Anne", "initials": "A"}, {"family": "de Oliveira", "given": "Tulio", "initials": "T", "orcid": "0000-0002-3027-5254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3dadcb78141a496ba76769d69667bf79.json"}}, {"family": "Druce", "given": "Julian", "initials": "J"}, {"family": "El Masry", "given": "Ihab", "initials": "I"}, {"family": "Evans", "given": "Roger", "initials": "R"}, {"family": "Gao", "given": "George F", "initials": "GF"}, {"family": "Gorbalenya", "given": "Alexander E", "initials": "AE", "orcid": "0000-0002-4967-7341", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76287aa33e034511934c0d16214ecaec.json"}}, {"family": "Hamblion", "given": "Esther", "initials": "E"}, {"family": "Herring", "given": "Belinda L", "initials": "BL"}, {"family": "Hodcroft", "given": "Emma", "initials": "E"}, {"family": "Holmes", "given": "Edward C", "initials": "EC", "orcid": "0000-0001-9596-3552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d784e4faf11463993992797e354dfc9.json"}}, {"family": "Kakkar", "given": "Manish", "initials": "M"}, {"family": "Khare", "given": "Shagun", "initials": "S"}, {"family": "Koopmans", "given": "Marion P G", "initials": "MPG", "orcid": "0000-0002-5204-2312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80d7f1e97b934289b7095013ef6e998d.json"}}, {"family": "Korber", "given": "Bette", "initials": "B"}, {"family": "Leite", "given": "Juliana", "initials": "J"}, {"family": "MacCannell", "given": "Duncan", "initials": "D"}, {"family": "Marklewitz", "given": "Marco", "initials": "M"}, {"family": "Maurer-Stroh", "given": "Sebastian", "initials": "S"}, {"family": "Rico", "given": "Jairo Andres Mendez", "initials": "JAM"}, {"family": "Munster", "given": "Vincent J", "initials": "VJ", "orcid": "0000-0002-2288-3196", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1f2569e7fe5442d968b3d89c88599d1.json"}}, {"family": "Neher", "given": "Richard", "initials": "R", "orcid": "0000-0003-2525-1407", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a31564f19214fbdb275578ed05a6bcb.json"}}, {"family": "Munnink", "given": "Bas Oude", "initials": "BO", "orcid": "0000-0002-9394-1189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19923669d04a47ebb5c7c93d20ecedc3.json"}}, {"family": "Pavlin", "given": "Boris I", "initials": "BI"}, {"family": "Peiris", "given": "Malik", "initials": "M", "orcid": "0000-0001-8217-5995", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9395f3f6fc44427b0dbf04988bfde22.json"}}, {"family": "Poon", "given": "Leo", "initials": "L", "orcid": "0000-0002-9101-7953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6595eec1d268410fad9018a8c7dd20c6.json"}}, {"family": "Pybus", "given": "Oliver", "initials": "O", "orcid": "0000-0002-8797-2667", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3770f4e971b34afbb61f6276d43767a1.json"}}, {"family": "Rambaut", "given": "Andrew", "initials": "A", "orcid": "0000-0003-4337-3707", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d25e62e17c243f3ab72304ca504e296.json"}}, {"family": "Resende", "given": "Paola", "initials": "P", "orcid": "0000-0002-2884-3662", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b51db0165c14686b31f624bf075f18b.json"}}, {"family": "Subissi", "given": "Lorenzo", "initials": "L", "orcid": "0000-0001-5147-575X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/454c226e834a4829a330df1c4b604855.json"}}, {"family": "Thiel", "given": "Volker", "initials": "V", "orcid": "0000-0002-5783-0887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c6d7b184da743e5975d3009cad5a802.json"}}, {"family": "Tong", "given": "Suxiang", "initials": "S"}, {"family": "van der Werf", "given": "Sylvie", "initials": "S", "orcid": "0000-0002-1148-4456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/610e999fc3fa4d24aceecf5a13122ecf.json"}}, {"family": "von Gottberg", "given": "Anne", "initials": "A"}, {"family": "Ziebuhr", "given": "John", "initials": "J", "orcid": "0000-0002-5741-8825", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4588eb2e70a4dafa2bdf92849f68837.json"}}, {"family": "Van Kerkhove", "given": "Maria D", "initials": "MD"}], "type": "journal article", "published": "2021-06-09", "journal": {"title": "Nat Microbiol", "issn": "2058-5276", "issn-l": null}, "abstract": null, "doi": "10.1038/s41564-021-00932-w", "pmid": "34108654", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41564-021-00932-w"}], "notes": [], "created": "2021-06-11T05:06:16.140Z", "modified": "2021-06-11T05:06:34.710Z"}, {"entity": "publication", "iuid": "e442369dddb84c968e6528b2c18d7536", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e442369dddb84c968e6528b2c18d7536.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e442369dddb84c968e6528b2c18d7536"}}, "title": "Reduction of pediatric emergency visits during the COVID-19 pandemic in a region with open preschools and schools.", "authors": [{"family": "Rhedin", "given": "Samuel Arthur", "initials": "SA"}, {"family": "Ryd Rinder", "given": "Malin", "initials": "M"}, {"family": "Hildenwall", "given": "Helena", "initials": "H"}, {"family": "Herlenius", "given": "Eric", "initials": "E"}, {"family": "Hertting", "given": "Olof", "initials": "O"}, {"family": "Luthander", "given": "Joachim", "initials": "J"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Nijman", "given": "Ruud", "initials": "R"}, {"family": "Olsson-\u00c5kefeldt", "given": "Selma", "initials": "S"}, {"family": "Alfven", "given": "Tobias", "initials": "T"}], "type": "journal article", "published": "2021-06-09", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": null, "issue": null, "pages": null}, "abstract": "Previous studies have reported a reduction in pediatric emergency visits for communicable diseases during the COVID-19 pandemic, which has been related to the use of face masks and school closures. As Sweden imposed less strict restrictions as compared to most countries we aimed to assess the effect of the behavioral changes, however without school closures and general usage of face masks in the society, on the spread of communicable diseases in children. We calculated cumulative incidences of pediatric emergency visits for lower respiratory tract infections (LRTIs), gastroenteritis and as a control diagnosis urinary tract infections (UTIs) comparing 2020 with 2018-2019. Our results suggests that the behavioral changes including improved basal hygiene routines and physical distancing, had a major impact on the disease transmission of LRTIs (cumulative incidence 0.24% in 2020 versus 0.57% during 2018-2019, p<0.001) and gastroenteritis (0.26% versus 0.87%, p<0.001) in children but observed a small increase in UTIs (0.22% versus 0.20%, p=0.01). This raises the question on to what extent some of these recommendations can and should be extended in the post pandemic era.", "doi": "10.1111/apa.15978", "pmid": "34107120", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-10T10:14:00.072Z", "modified": "2021-07-14T09:35:15.224Z"}, {"entity": "publication", "iuid": "415035fac5ab476b81c0a067ef352a19", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/415035fac5ab476b81c0a067ef352a19.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/415035fac5ab476b81c0a067ef352a19"}}, "title": "COVID-19 and Health Care Leaders: How Could Emotional Intelligence Be a Helpful Resource during a Pandemic?", "authors": [{"family": "Rossettini", "given": "Giacomo", "initials": "G"}, {"family": "Conti", "given": "Cristiana", "initials": "C"}, {"family": "Suardelli", "given": "Martina", "initials": "M"}, {"family": "Geri", "given": "Tommaso", "initials": "T"}, {"family": "Palese", "given": "Alvisa", "initials": "A"}, {"family": "Turolla", "given": "Andrea", "initials": "A"}, {"family": "Lovato", "given": "Andrea", "initials": "A"}, {"family": "Gianola", "given": "Silvia", "initials": "S"}, {"family": "Dell'Isola", "given": "Andrea", "initials": "A"}], "type": "journal article", "published": "2021-06-09", "journal": {"title": "Phys Ther", "issn": "1538-6724", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1093/ptj/pzab143", "pmid": "34101807", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6294530"}], "notes": [], "created": "2021-06-09T19:03:08.563Z", "modified": "2021-07-14T09:37:46.670Z"}, {"entity": "publication", "iuid": "61d6b962006344b99192d107bf56ae86", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61d6b962006344b99192d107bf56ae86.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61d6b962006344b99192d107bf56ae86"}}, "title": "Assessing the effects of calculated inaction on national responses to the COVID-19 crisis.", "authors": [{"family": "Zahariadis", "given": "Nikolaos", "initials": "N", "orcid": "0000-0003-2457-0561", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51bd7d14c9584d04a7eafba7f440c34c.json"}}, {"family": "Ceccoli", "given": "Stephen", "initials": "S", "orcid": "0000-0003-3789-061X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/036f98a2d87d464d98ddc7dc876467cd.json"}}, {"family": "Petridou", "given": "Evangelia", "initials": "E", "orcid": "0000-0001-7316-4899", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21de455914874bdf8fbaf544e51053b0.json"}}], "type": "journal article", "published": "2021-06-09", "journal": {"title": "Risk Hazards Crisis Public Policy", "issn": "1944-4079", "issn-l": null}, "abstract": "How does calculated inaction affect subsequent responses to the COVID-19 crisis? We argue that when governments employ calculated inaction during crises, they are more likely to manipulate the technical (scientific) aspects of national responses and highlight symbolic politics, each in the name of projecting power and strengthening the regime's governing authority. Using theoretical insight from McConnell and 't Hart's policy inaction typology, we investigate sense-making and crisis response narratives in China and Greece. We conclude with implications for policymaking and the crisis management literature.", "doi": "10.1002/rhc3.12230", "pmid": "34226845", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "RHC312230"}, {"db": "pmc", "key": "PMC8242484"}], "notes": [], "created": "2021-08-06T08:41:54.181Z", "modified": "2021-08-06T08:41:54.277Z"}, {"entity": "publication", "iuid": "7b0d6322d30546cba83126492632adeb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b0d6322d30546cba83126492632adeb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b0d6322d30546cba83126492632adeb"}}, "title": "Impact of COVID-19 pandemic on mental health and health behaviors in Swedish adolescents.", "authors": [{"family": "Chen", "given": "Yun", "initials": "Y"}, {"family": "Osika", "given": "Walter", "initials": "W"}, {"family": "Henriksson", "given": "G\u00f6ran", "initials": "G"}, {"family": "Dahlstrand", "given": "Johan", "initials": "J"}, {"family": "Friberg", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2021-06-08", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": null, "issue": null, "pages": "14034948211021724"}, "abstract": "There is an urgent need to explore the impact of the COVID-19 pandemic on adolescent mental health and health behaviours. To date, there are no such studies on Swedish adolescents. As COVID-19 emerged in the middle of our ongoing 2-year follow-up examination of the Study of Adolescence Resilience and Stress, we had the unique opportunity to use the corona outbreak as a 'natural experiment' to study the impact of COVID-19 on 15-year-old adolescents in Sweden.\r\n\r\nAdolescents (baseline age 13.6\u00b10.4 years) were recruited from schools in western Sweden (during the COVID-19 outbreak schools were kept open for those under 16 years of age). The COVID-19 pandemic reached Sweden on 31 January 2020. A total of 1316 adolescents answered the 2-year follow-up survey before (unexposed to COVID-19 pandemic, controls) and 584 after 1 February 2020 (COVID19-exposed). Data on stress, psychosomatic symptoms, happiness, relationships with parents and peers, school and health behaviours were collected.\r\n\r\nAdolescents reported higher levels of stress and psychosomatic symptoms and lower levels of happiness at follow-up compared to baseline. These changes occurred to a similar extent in both the control and COVID-19-exposed groups. Likewise, the COVID-19-exposed group showed no deterioration in peer relations or relations with parents versus controls. We did not find any significant differences between groups regarding sleep duration and physical activity. Conclusions: Swedish adolescents exposed to COVID-19 during most of 2020 showed no differences in longitudinal changes in mental health, relationships with parents and peers, and health behaviours compared to those not exposed to COVID-19.", "doi": "10.1177/14034948211021724", "pmid": "34100665", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Funder: H2020": null, "Funder: VR": null}, "xrefs": [], "notes": [], "created": "2021-06-09T19:04:07.985Z", "modified": "2021-07-14T09:24:47.762Z"}, {"entity": "publication", "iuid": "daeeea3c68554772b7f455f7328bfc44", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/daeeea3c68554772b7f455f7328bfc44.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/daeeea3c68554772b7f455f7328bfc44"}}, "title": "Dying from cancer with COVID-19: age, sex, socio-economic status, and comorbidities", "authors": [{"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "Hedman", "given": "Christel", "initials": "C"}, {"family": "Adlitzer", "given": "Helena", "initials": "H"}, {"family": "Schultz", "given": "Torbj\u00f6rn", "initials": "T"}], "type": "journal-article", "published": "2021-06-08", "journal": {"title": "Acta Oncologica", "issn": "0284-186X", "issn-l": null, "volume": null, "issue": null, "pages": "1-6"}, "abstract": "The COVID-19 pandemic has caused excess deaths (all causes) and has disproportionately affected the elderly with certain characteristics.\r\n\r\nTo study how COVID-19 affected cancer deaths regarding age, sex, socio-economic status, comorbidities, and access to palliative care. An additional objective was to study changes in place of care and death.\r\n\r\nA descriptive, retrospective study of all cancer patients who died during March-May 2020 in the Stockholm region, n = 1467 of which 278 died with a COVID-19 diagnosis, compared with deaths in 2016-2019. The Stockholm Regional Council's central data warehouse was used. T-tests, 95% CI, Wilcoxon and chi-squared tests were used for comparisons.\r\n\r\nThere were excess cancer deaths compared with 2016-2019 ( p < 0.001) and patients dying with a COVID-19 diagnosis were older (79.7 vs. 75.9 years, p < 0.0001), more often male (67% vs. 55%, p < 0.0001), and had more comorbidities (Charlson Comorbidity Index 1.6 vs. 1.1, p < 0.0001). Patients with COVID-19 more seldom had access to palliative care (34% vs. 59%, p = 0.008), had more changes in place of care during the last two weeks of life (p < 0.0001) and died more often in acute hospitals (34% vs. 14%, p < 0.0001). For the subgroup with access to palliative care, the hospital deaths for individuals with and without a COVID-19 diagnosis were 11% and 4%, respectively (p = 0.008).\r\n\r\nCancer patients dying with a COVID-19 diagnosis were older, more often male, and had more comorbidities. A COVID-19 diagnosis negatively affected the probability of being admitted to specialized palliative care and increased the likelihood of dying in an acute hospital.", "doi": "10.1080/0284186x.2021.1934536", "pmid": "34101521", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-09T19:03:41.769Z", "modified": "2021-07-14T09:23:35.833Z"}, {"entity": "publication", "iuid": "b3310f859ee940a4b51f6c4b608645f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b3310f859ee940a4b51f6c4b608645f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b3310f859ee940a4b51f6c4b608645f4"}}, "title": "Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2", "authors": [{"family": "O'Toole", "given": "A", "initials": "A"}, {"family": "Hill", "given": "V", "initials": "V"}], "type": "journal article", "published": "2021-06-07", "journal": {"title": "Wellcome Open Res", "issn": "2398-502X", "issn-l": null, "volume": "6", "issue": null, "pages": "121"}, "abstract": "Late in 2020, two genetically-distinct clusters of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with mutations of biological concern were reported, one in the United Kingdom and one in South Africa. Using a combination of data from routine surveillance, genomic sequencing and international travel we track the international dispersal of lineages B.1.1.7 and B.1.351 (variant 501Y-V2). We account for potential biases in genomic surveillance efforts by including passenger volumes from location of where the lineage was first reported, London and South Africa respectively. Using the software tool grinch (global report investigating novel coronavirus haplotypes), we track the international spread of lineages of concern with automated daily reports, Further, we have built a custom tracking website (cov-lineages.org/global_report.html) which hosts this daily report and will continue to include novel SARS-CoV-2 lineages of concern as they are detected.", "doi": "https://doi.org/10.12688/wellcomeopenres.16661.1", "pmid": "34095513", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pmc", "key": "PMC8176267"}, {"db": "URL", "key": "https://zenodo.org/record/4642401#.YZZRQS8w3OQ", "description": "Accession IDs included in publication Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2"}, {"db": "URL", "key": "https://zenodo.org/record/4704471#.YZZRyS8w3OQ", "description": "Supplementary materials with group affiliations for Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2"}, {"db": "URL", "key": "https://zenodo.org/record/4640140#.YZZRRy8w1TY", "description": "Data underlying the cov-lineages.org website"}], "notes": [], "created": "2021-06-07T15:39:21.116Z", "modified": "2021-11-18T13:17:11.237Z"}, {"entity": "publication", "iuid": "b67d71cac8ed4f03995e13a88ac7e12a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b67d71cac8ed4f03995e13a88ac7e12a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b67d71cac8ed4f03995e13a88ac7e12a"}}, "title": "Strategies to Improve Antimicrobial Utilization with a Special Focus on Developing Countries.", "authors": [{"family": "Godman", "given": "Brian", "initials": "B", "orcid": "0000-0001-6539-6972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e76103610619453b84eab8de36f169cc.json"}}, {"family": "Egwuenu", "given": "Abiodun", "initials": "A", "orcid": "0000-0002-9369-4771", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70e982f868684b5780a54ecc8aa5a943.json"}}, {"family": "Haque", "given": "Mainul", "initials": "M", "orcid": "0000-0002-6124-7993", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b474f4ad9837460e84f88097a5cd639f.json"}}, {"family": "Malande", "given": "Oliver Ombeva", "initials": "OO"}, {"family": "Schellack", "given": "Natalie", "initials": "N"}, {"family": "Kumar", "given": "Santosh", "initials": "S", "orcid": "0000-0002-5117-7872", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e56ccd71c894b54a1412fc4a53652c2.json"}}, {"family": "Saleem", "given": "Zikria", "initials": "Z", "orcid": "0000-0003-3202-6347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/029d4b30cc724148a1225090d3f063ee.json"}}, {"family": "Sneddon", "given": "Jacqueline", "initials": "J"}, {"family": "Hoxha", "given": "Iris", "initials": "I"}, {"family": "Islam", "given": "Salequl", "initials": "S"}, {"family": "Mwita", "given": "Julius", "initials": "J"}, {"family": "do Nascimento", "given": "Renata Cristina Rezende Macedo", "initials": "RCRM", "orcid": "0000-0001-7756-2157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eec0a62241f4ea8931a95d92f34fa73.json"}}, {"family": "Dias God\u00f3i", "given": "Isabella Piassi", "initials": "IP", "orcid": "0000-0002-0568-6625", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6ade8b9c4e94a64add5b0d5b6911a27.json"}}, {"family": "Niba", "given": "Loveline Lum", "initials": "LL", "orcid": "0000-0002-5938-4913", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/321efd54c80f410a97a4887bcbb9e4d5.json"}}, {"family": "Amu", "given": "Adefolarin A", "initials": "AA"}, {"family": "Acolatse", "given": "Joseph", "initials": "J", "orcid": "0000-0001-6556-3208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c03eeda55764c609acb5cb91dacbbd3.json"}}, {"family": "Incoom", "given": "Robert", "initials": "R"}, {"family": "Sefah", "given": "Israel Abebrese", "initials": "IA", "orcid": "0000-0001-6963-0519", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/073a513f62804d9fb48c4f846c747c54.json"}}, {"family": "Opanga", "given": "Sylvia", "initials": "S"}, {"family": "Kurdi", "given": "Amanj", "initials": "A", "orcid": "0000-0001-5036-1988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be9bf17786754363929dc0faaae8c323.json"}}, {"family": "Chikowe", "given": "Ibrahim", "initials": "I", "orcid": "0000-0002-8231-9140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9eec6427097437eb172355a62854faf.json"}}, {"family": "Khuluza", "given": "Felix", "initials": "F"}, {"family": "Kibuule", "given": "Dan", "initials": "D", "orcid": "0000-0002-6908-2177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4344137451d04535a5875183b9abc24e.json"}}, {"family": "Ogunleye", "given": "Olayinka O", "initials": "OO"}, {"family": "Olalekan", "given": "Adesola", "initials": "A", "orcid": "0000-0002-8921-1909", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4780e3a28e2b44a0ac5c20cecc469852.json"}}, {"family": "Markovic-Pekovic", "given": "Vanda", "initials": "V"}, {"family": "Meyer", "given": "Johanna C", "initials": "JC"}, {"family": "Alfadl", "given": "Abubakr", "initials": "A"}, {"family": "Phuong", "given": "Thuy Nguyen Thi", "initials": "TNT"}, {"family": "Kalungia", "given": "Aubrey C", "initials": "AC"}, {"family": "Campbell", "given": "Stephen", "initials": "S"}, {"family": "Pisana", "given": "Alice", "initials": "A"}, {"family": "Wale", "given": "Janney", "initials": "J"}, {"family": "Seaton", "given": "R Andrew", "initials": "RA"}], "type": "journal article", "published": "2021-06-07", "journal": {"title": "Life (Basel)", "issn": "2075-1729", "issn-l": null, "volume": "11", "issue": "6", "pages": null}, "abstract": "Antimicrobial resistance (AMR) is a high priority across countries as it increases morbidity, mortality and costs. Concerns with AMR have resulted in multiple initiatives internationally, nationally and regionally to enhance appropriate antibiotic utilization across sectors to reduce AMR, with the overuse of antibiotics exacerbated by the COVID-19 pandemic. Effectively tackling AMR is crucial for all countries. Principally a narrative review of ongoing activities across sectors was undertaken to improve antimicrobial use and address issues with vaccines including COVID-19. Point prevalence surveys have been successful in hospitals to identify areas for quality improvement programs, principally centering on antimicrobial stewardship programs. These include reducing prolonged antibiotic use to prevent surgical site infections. Multiple activities centering on education have been successful in reducing inappropriate prescribing and dispensing of antimicrobials in ambulatory care for essentially viral infections such as acute respiratory infections. It is imperative to develop new quality indicators for ambulatory care given current concerns, and instigate programs with clear public health messaging to reduce misinformation, essential for pandemics. Regular access to effective treatments is needed to reduce resistance to treatments for HIV, malaria and tuberculosis. Key stakeholder groups can instigate multiple initiatives to reduce AMR. These need to be followed up.", "doi": "10.3390/life11060528", "pmid": "34200116", "labels": {"Type: Review": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8229985"}, {"db": "pii", "key": "life11060528"}], "notes": [], "created": "2021-07-05T14:33:03.361Z", "modified": "2023-06-19T07:30:35.555Z"}, {"entity": "publication", "iuid": "af7bab2d24e543b19d644dbd8546b0a7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/af7bab2d24e543b19d644dbd8546b0a7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/af7bab2d24e543b19d644dbd8546b0a7"}}, "title": "SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease?", "authors": [{"family": "Sancho-Shimizu", "given": "Vanessa", "initials": "V"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A"}, {"family": "Biggs", "given": "Catherine M", "initials": "CM"}, {"family": "Toubiana", "given": "Julie", "initials": "J"}, {"family": "Lucas", "given": "Carrie L", "initials": "CL"}, {"family": "Henrickson", "given": "Sarah E", "initials": "SE"}, {"family": "Belot", "given": "Alexandre", "initials": "A"}, {"family": "MIS-C@CHGE", "given": "", "initials": ""}, {"family": "Tangye", "given": "Stuart G", "initials": "SG"}, {"family": "Milner", "given": "Joshua D", "initials": "JD"}, {"family": "Levin", "given": "Michael", "initials": "M"}, {"family": "Abel", "given": "Laurent", "initials": "L"}, {"family": "Bogunovic", "given": "Dusan", "initials": "D"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}], "type": "journal article", "published": "2021-06-07", "journal": {"title": "J Exp Med", "issn": "1540-9538", "volume": "218", "issue": "6", "issn-l": null}, "abstract": "Multisystem inflammatory syndrome in children (MIS-C) emerged in April 2020 in communities with high COVID-19 rates. This new condition is heterogenous but resembles Kawasaki disease (KD), a well-known but poorly understood and clinically heterogenous pediatric inflammatory condition for which weak associations have been found with a myriad of viral illnesses. Epidemiological data clearly indicate that SARS-CoV-2 is the trigger for MIS-C, which typically occurs about 1 mo after infection. These findings support the hypothesis of viral triggers for the various forms of classic KD. We further suggest that rare inborn errors of immunity (IEIs) altering the immune response to SARS-CoV-2 may underlie the pathogenesis of MIS-C in some children. The discovery of monogenic IEIs underlying MIS-C would shed light on its pathogenesis, paving the way for a new genetic approach to classic KD, revisited as a heterogeneous collection of IEIs to viruses.", "doi": "10.1084/jem.20210446", "pmid": "33904890", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "212029"}], "notes": [], "created": "2021-04-29T10:16:49.682Z", "modified": "2021-04-29T10:16:49.704Z"}, {"entity": "publication", "iuid": "e780251b40974ddea6e2be08b3dc8076", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e780251b40974ddea6e2be08b3dc8076.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e780251b40974ddea6e2be08b3dc8076"}}, "title": "Missed nursing care during the COVID-19 pandemic: a comparative observational study.", "authors": [{"family": "von Vogelsang", "given": "Ann-Christin", "initials": "A"}, {"family": "G\u00f6ransson", "given": "Katarina E", "initials": "KE"}, {"family": "Falk", "given": "Ann-Charlotte", "initials": "A"}, {"family": "Nymark", "given": "Carolin", "initials": "C"}], "type": "journal article", "published": "2021-06-07", "journal": {"title": "J Nurs Manag", "issn": "1365-2834", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To evaluate frequencies, types of, and reasons for missed nursing care during the COVID-19 pandemic at inpatient wards in a highly specialized university hospital.\r\n\r\nRegistered nurse/patient ratio and nursing competence is known to affect patient outcomes. The first wave of the COVID-19 pandemic entailed novel ways for staffing to meet the expected increased acute care demand, which potentially could impact on quality of care.\r\n\r\nA comparative cross-sectional study was conducted, using the MISSCARE Survey. A sample of nursing staff during the first wave of the COVID-19 pandemic (n=130) was compared with a reference sample (n=157).\r\n\r\nFew differences between samples concerning elements of missed care, and no significant differences concerning reasons for missed care were found. Most participants perceived the quality of care and the patient safety to be good.\r\n\r\nThe results may be explained by three factors: maintained registered nurse/patient ratio, patients' dependency levels and that nursing managers could maintain the staffing needs with a sufficient skill mix.\r\n\r\nNursing managers impact on the occurrence of MNC; to provide a sufficient registered nurse/patient ratio and skill mix when staffing. They play an important role in anticipatory planning, and during infectious diseases outbreaks.", "doi": "10.1111/jonm.13392", "pmid": "34097799", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-08T09:02:41.566Z", "modified": "2021-07-14T09:21:04.995Z"}, {"entity": "publication", "iuid": "00ce2e2616f845da86a5b7e7c6321f81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/00ce2e2616f845da86a5b7e7c6321f81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/00ce2e2616f845da86a5b7e7c6321f81"}}, "title": "Long-term consequences in critically ill COVID-19 patients: a prospective cohort study.", "authors": [{"family": "Schandl", "given": "Anna", "initials": "A"}, {"family": "Hedman", "given": "Anders", "initials": "A"}, {"family": "Lyng\u00e5", "given": "Patrik", "initials": "P"}, {"family": "Fathi Tachinabad", "given": "Sozan", "initials": "S"}, {"family": "Svefors", "given": "Jessica", "initials": "J"}, {"family": "Ro\u00ebl", "given": "Mari", "initials": "M"}, {"family": "Geborek", "given": "Anne", "initials": "A"}, {"family": "Franko", "given": "Mikael Andersson", "initials": "MA"}, {"family": "S\u00f6derberg", "given": "M\u00e5rten", "initials": "M"}, {"family": "Darlington", "given": "Pernilla", "initials": "P"}], "type": "journal article", "published": "2021-06-07", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "volume": null, "issue": null, "issn-l": "0001-5172"}, "abstract": "COVID-19 can cause severe disease with need of treatment in the intensive care unit (ICU) for several weeks. Increased knowledge is needed about the long-term consequences.\n\nThis is a single-center prospective follow-up study of COVID-19 patients admitted to the ICU for respiratory organ support between March and July 2020. Patients with invasive ventilation were compared with those with high-flow nasal oxygen (HFNO) or non-invasive ventilation (NIV) regarding functional outcome and health-related qualify of life. The mean follow-up time was 5 months after ICU discharge and included clinical history, three well-validated questionnaires about health-related quality of life and psychological health, pulmonary function test, 6-minute walk test (6MWT) and work ability. Data were analyzed with multivariable general linear and logistic regression models with 95% confidence intervals.\n\nAmong 248 ICU patients, 200 patients survived. Of these, 113 patients came for follow-up. Seventy patients (62%) had received invasive ventilation. Most patients reported impaired health-related quality of life. Approximately one third suffered from posttraumatic stress, anxiety and depression. Twenty-six percent had reduced total lung capacity, 34% had reduced 6MWT and 50% worked fulltime. The outcomes were similar regardless of ventilatory support, but invasive ventilation was associated with more bodily pain (MSD -19, 95% CI: -32 to -5) and <80% total lung capacity (OR 4.1, 95% CI: 1.3-16.5).\n\nAmong survivors of Covid-19 who required respiratory organ support, outcomes 5 months after discharge from ICU were largely similar among those requiring invasive compared to non-invasive ventilation.", "doi": "10.1111/aas.13939", "pmid": "34097753", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-08T09:01:42.327Z", "modified": "2021-06-08T09:05:02.198Z"}, {"entity": "publication", "iuid": "c8464d3e58c54986b1b603fae7036672", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c8464d3e58c54986b1b603fae7036672.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c8464d3e58c54986b1b603fae7036672"}}, "title": "A Cross-Sectional Survey on Medication Management Practices for Noncommunicable Diseases in Europe During the Second Wave of the COVID-19 Pandemic", "authors": [{"family": "\u00c1gh", "given": "Tam\u00e1s", "initials": "T"}, {"family": "van Boven", "given": "Job FM", "initials": "JF"}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Menditto", "given": "Enrica", "initials": "E"}, {"family": "Pinnock", "given": "Hilary", "initials": "H"}, {"family": "Tsiligianni", "given": "Ioanna", "initials": "I"}, {"family": "Petrova", "given": "Guenka", "initials": "G"}, {"family": "Poto\u010dnjak", "given": "Ines", "initials": "I"}, {"family": "Kamberi", "given": "Fatjona", "initials": "F"}, {"family": "Kardas", "given": "Przemyslaw", "initials": "P"}, {"family": null, "given": "", "initials": ""}], "type": "journal-article", "published": "2021-06-07", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "12", "issn-l": "1663-9812"}, "abstract": null, "doi": "10.3389/fphar.2021.685696", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:16:17.183Z", "modified": "2021-06-28T18:16:17.194Z"}, {"entity": "publication", "iuid": "a39156b910c74d5eab4c6f6bb1e90627", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a39156b910c74d5eab4c6f6bb1e90627.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a39156b910c74d5eab4c6f6bb1e90627"}}, "title": "Open science saves lives: lessons from the COVID-19 pandemic.", "authors": [{"family": "Besan\u00e7on", "given": "Lonni", "initials": "L"}, {"family": "Peiffer-Smadja", "given": "Nathan", "initials": "N"}, {"family": "Segalas", "given": "Corentin", "initials": "C"}, {"family": "Jiang", "given": "Haiting", "initials": "H"}, {"family": "Masuzzo", "given": "Paola", "initials": "P"}, {"family": "Smout", "given": "Cooper", "initials": "C"}, {"family": "Billy", "given": "Eric", "initials": "E"}, {"family": "Deforet", "given": "Maxime", "initials": "M"}, {"family": "Leyrat", "given": "Cl\u00e9mence", "initials": "C"}], "type": "letter", "published": "2021-06-05", "journal": {"title": "BMC Med Res Methodol", "issn": "1471-2288", "issn-l": null, "volume": "21", "issue": "1", "pages": "117"}, "abstract": "In the last decade Open Science principles have been successfully advocated for and are being slowly adopted in different research communities. In response to the COVID-19 pandemic many publishers and researchers have sped up their adoption of Open Science practices, sometimes embracing them fully and sometimes partially or in a sub-optimal manner. In this article, we express concerns about the violation of some of the Open Science principles and its potential impact on the quality of research output. We provide evidence of the misuses of these principles at different stages of the scientific process. We call for a wider adoption of Open Science practices in the hope that this work will encourage a broader endorsement of Open Science principles and serve as a reminder that science should always be a rigorous process, reliable and transparent, especially in the context of a pandemic where research findings are being translated into practice even more rapidly. We provide all data and scripts at https://osf.io/renxy/ .", "doi": "10.1186/s12874-021-01304-y", "pmid": "34090351", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12874-021-01304-y"}], "notes": [], "created": "2021-06-07T14:16:08.799Z", "modified": "2021-06-08T08:47:19.991Z"}, {"entity": "publication", "iuid": "d347c79105404ea8a601a07b6e2c0236", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d347c79105404ea8a601a07b6e2c0236.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d347c79105404ea8a601a07b6e2c0236"}}, "title": "Vaccine allergy: evidence to consider for COVID-19 vaccines.", "authors": [{"family": "Nilsson", "given": "Lennart", "initials": "L"}, {"family": "Csuth", "given": "\u00c1gnes", "initials": "\u00c1"}, {"family": "Storsaeter", "given": "Jann", "initials": "J"}, {"family": "Garvey", "given": "Lene H", "initials": "LH"}, {"family": "Jenmalm", "given": "Maria C", "initials": "MC"}], "type": "journal article", "published": "2021-06-04", "journal": {"title": "Curr Opin Allergy Clin Immunol", "issn": "1473-6322", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Whereas the COVID-19 pandemic has changed our lives worldwide, we hope that vaccination can combat the disease. We propose how to evaluate suspected severe allergic reactions to the vaccines so that as many as possible may be safely vaccinated.\r\n\r\nRare cases of severe allergic reactions after COVID-19 vaccination have been observed, seemingly at a higher frequency than for other vaccines. Few excipients are likely to have caused these reactions. IgE-mediated reactions to polyethylene glycol (PEG) and its derivatives are the most suspected, albeit hitherto unproven, causes. We suggest to make a diagnosis based on skin tests with PEG and PEG derivatives and that these be considered in relation to the decisions required before the first and the second vaccine dose. A vaccine without these excipients is available, but published data about its side effects are limited.\r\n\r\nThe underlying immunological mechanisms of the rare severe allergic reactions to the COVID-19 vaccines are poorly understood and need to be clarified. Identifying those who have an undiagnosed allergy to PEG and PEG derivatives is crucial before vaccination, and these substances are found in laxatives, cosmetics and in 30% of all our medications today.", "doi": "10.1097/ACI.0000000000000762", "pmid": "34091550", "labels": {"Type: Journal article": null, "Category: Health": null, "Research Area: Vaccine": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "00130832-900000000-98999"}], "notes": [], "created": "2021-06-07T14:06:39.950Z", "modified": "2021-12-06T12:28:38.925Z"}, {"entity": "publication", "iuid": "6c24155fe1c44fd0922da41e251baba7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c24155fe1c44fd0922da41e251baba7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c24155fe1c44fd0922da41e251baba7"}}, "title": "Schools do not need to close to reduce COVID\u201019 but other measures are advisable", "authors": [{"family": "Axelsson", "given": "Inge", "initials": "I"}], "type": "journal-article", "published": "2021-06-04", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1111/apa.15951", "pmid": null, "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-06-07T05:46:39.495Z", "modified": "2021-06-07T05:46:39.501Z"}, {"entity": "publication", "iuid": "a6ea0fe07eec4c6d918ce3abedc7e950", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6ea0fe07eec4c6d918ce3abedc7e950.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6ea0fe07eec4c6d918ce3abedc7e950"}}, "title": "Rapid and Sensitive Detection of SARS-CoV-2 Infection Using Quantitative Peptide Enrichment LC-MS/MS Analysis", "authors": [{"family": "Hober", "given": "Andreas", "initials": "A"}, {"family": "Hua", "given": "Tran Minh Khue", "initials": "TMK"}, {"family": "Foley", "given": "Dominic", "initials": "D"}, {"family": "McDonald", "given": "Thomas", "initials": "T"}, {"family": "Vissers", "given": "Johannes P C", "initials": "JPC"}, {"family": "Pattison", "given": "Rebecca", "initials": "R"}, {"family": "Ferries", "given": "Samantha", "initials": "S"}, {"family": "Hermansson", "given": "Sigurd", "initials": "S"}, {"family": "Betner", "given": "Ingvar", "initials": "I"}, {"family": "Uhlen", "given": "Mathias", "initials": "M"}, {"family": "Razavi", "given": "Morteza", "initials": "M"}, {"family": "Yip", "given": "Richard", "initials": "R"}, {"family": "Pope", "given": "Matthew E", "initials": "ME"}, {"family": "Pearson", "given": "Terry W", "initials": "TW"}, {"family": "Anderson", "given": "N Leigh", "initials": "NL"}, {"family": "Bartlett", "given": "Amy", "initials": "A"}, {"family": "Calton", "given": "Lisa", "initials": "L"}, {"family": "Alm", "given": "Jessica J", "initials": "JJ"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Edfors", "given": "Fredrik", "initials": "F"}], "type": "posted-content", "published": "2021-06-04", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.06.02.21258097", "pmid": null, "labels": {"Type: Preprint": null, "Category: Imaging": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-06-09T10:38:27.339Z", "modified": "2021-06-18T09:12:42.452Z"}, {"entity": "publication", "iuid": "dc71c9532399475e89ef881d1800a4ec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dc71c9532399475e89ef881d1800a4ec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dc71c9532399475e89ef881d1800a4ec"}}, "title": "Plasma ACE2 predicts outcome of COVID-19 in hospitalized patients.", "authors": [{"family": "Kragstrup", "given": "Tue W", "initials": "TW"}, {"family": "Singh", "given": "Helene S\u00f8gaard", "initials": "HS"}, {"family": "Grundberg", "given": "Ida", "initials": "I"}, {"family": "Nielsen", "given": "Ane Langkilde-Lauesen", "initials": "AL"}, {"family": "Rivellese", "given": "Felice", "initials": "F"}, {"family": "Mehta", "given": "Arnav", "initials": "A"}, {"family": "Goldberg", "given": "Marcia B", "initials": "MB"}, {"family": "Filbin", "given": "Michael R", "initials": "MR"}, {"family": "Qvist", "given": "Per", "initials": "P"}, {"family": "Bibby", "given": "Bo Martin", "initials": "BM"}], "type": "journal article", "published": "2021-06-04", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "6", "pages": "e0252799"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin converting enzyme 2 (ACE2) enabling entrance of the virus into cells and causing the infection termed coronavirus disease of 2019 (COVID-19). Here, we investigate associations between plasma ACE2 and outcome of COVID-19.\r\n\r\nThis analysis used data from a large longitudinal study of 306 COVID-19 positive patients and 78 COVID-19 negative patients (MGH Emergency Department COVID-19 Cohort). Comprehensive clinical data were collected on this cohort, including 28-day outcomes. The samples were run on the Olink\u00ae Explore 1536 platform which includes measurement of the ACE2 protein. High admission plasma ACE2 in COVID-19 patients was associated with increased maximal illness severity within 28 days with OR = 1.8, 95%-CI: 1.4-2.3 (P < 0.0001). Plasma ACE2 was significantly higher in COVID-19 patients with hypertension compared with patients without hypertension (P = 0.0045). Circulating ACE2 was also significantly higher in COVID-19 patients with pre-existing heart conditions and kidney disease compared with patients without these pre-existing conditions (P = 0.0363 and P = 0.0303, respectively).\r\n\r\nThis study suggests that measuring plasma ACE2 is potentially valuable in predicting COVID-19 outcomes. Further, ACE2 could be a link between COVID-19 illness severity and its established risk factors hypertension, pre-existing heart disease and pre-existing kidney disease.", "doi": "10.1371/journal.pone.0252799", "pmid": "34086837", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-06434"}], "notes": [], "created": "2021-06-08T08:37:57.861Z", "modified": "2021-06-08T08:38:14.665Z"}, {"entity": "publication", "iuid": "d4851cb729ba4249b06c14b4894c8394", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4851cb729ba4249b06c14b4894c8394.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4851cb729ba4249b06c14b4894c8394"}}, "title": "Characterization of dysphagia and laryngeal findings in COVID-19 patients treated in the ICU-An observational clinical study.", "authors": [{"family": "Osbeck Sandblom", "given": "Hanna", "initials": "H"}, {"family": "Dotevall", "given": "Hans", "initials": "H"}, {"family": "Svennerholm", "given": "Kristina", "initials": "K"}, {"family": "Tuomi", "given": "Lisa", "initials": "L"}, {"family": "Finizia", "given": "Caterina", "initials": "C"}], "type": "journal article", "published": "2021-06-04", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "6", "pages": "e0252347"}, "abstract": "Dysphagia appears to be common in patients with severe COVID-19. Information about the characteristics of dysphagia and laryngeal findings in COVID-19 patients treated in the intensive care unit (ICU) is still limited.\r\n\r\nThe aim of this study was to evaluate oropharyngeal swallowing function and laryngeal appearance and function in patients with severe COVID-19.\r\n\r\nA series of 25 ICU patients with COVID-19 and signs of dysphagia were examined with fiberendoscopic evaluation of swallowing (FEES) during the latter stage of ICU care or after discharge from the ICU. Swallowing function and laryngeal findings were assessed with standard rating scales from video recordings.\r\n\r\nPooling of secretions was found in 92% of patients. Eleven patients (44%) showed signs of silent aspiration to the trachea on at least one occasion. All patients showed residue after swallowing to some degree both in the vallecula and hypopharynx. Seventy-six percent of patients had impaired vocal cord movement. Erythema of the vocal folds was found in 60% of patients and edema in the arytenoid region in 60%.\r\n\r\nImpairment of oropharyngeal swallowing function and abnormal laryngeal findings were common in this series of patients with severe COVID-19 treated in the ICU. To avoid complications related to dysphagia in this patient group, it seems to be of great importance to evaluate the swallowing function as a standard procedure, preferably at an early stage, before initiation of oral intake. Fiberendoscopic evaluation of swallowing is preferred due to the high incidence of pooling of secretion in the hypopharynx, silent aspiration, and residuals. Further studies of the impact on swallowing function in short- and long-term in patients with COVID-19 are warranted.", "doi": "10.1371/journal.pone.0252347", "pmid": "34086717", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-05126"}], "notes": [], "created": "2021-06-08T08:38:49.661Z", "modified": "2021-06-08T08:39:11.061Z"}, {"entity": "publication", "iuid": "a7a8f3f6520a4ac7979f9f30261eb800", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7a8f3f6520a4ac7979f9f30261eb800.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7a8f3f6520a4ac7979f9f30261eb800"}}, "title": "Changes in daily life and wellbeing in adults, 70 years and older, in the beginning of the COVID-19 pandemic", "authors": [{"family": "Fristedt", "given": "Sofi", "initials": "S"}, {"family": "Carlsson", "given": "Gunilla", "initials": "G"}, {"family": "Kyl\u00e9n", "given": "Maya", "initials": "M"}, {"family": "Jonsson", "given": "Oskar", "initials": "O"}, {"family": "Granbom", "given": "Marianne", "initials": "M"}], "type": "journal-article", "published": "2021-06-04", "journal": {"title": "Scandinavian Journal of Occupational Therapy", "issn": "1103-8128", "issn-l": null, "volume": null, "issue": null, "pages": "1-11"}, "abstract": null, "doi": "10.1080/11038128.2021.1933171", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-08T08:42:45.724Z", "modified": "2021-07-14T09:19:04.290Z"}, {"entity": "publication", "iuid": "91ebcee90c8b4fefa612a55ae006431e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/91ebcee90c8b4fefa612a55ae006431e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/91ebcee90c8b4fefa612a55ae006431e"}}, "title": "Sweden's coronavirus strategy: The Public Health Agency and the sites of controversy.", "authors": [{"family": "Pashakhanlou", "given": "Arash Heydarian", "initials": "AH", "orcid": "0000-0002-5451-298X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d282433a84da4177a3b91e6529f929c8.json"}}], "type": "journal article", "published": "2021-06-03", "journal": {"title": "World Med Health Policy", "issn": "2153-2028", "issn-l": null}, "abstract": "In contrast to the vast majority of Western countries, Sweden left large segments of the society open instead of imposing a lockdown to combat the spread of the coronavirus. As a result, the Swedish COVID-19 measures, largely devised by its expert agency on health, garnered widespread international attention. Despite the global interest in the corona strategy of the Public Health Agency of Sweden (PHAS), there are currently no systematic studies on their COVID-19 policy. The present investigation focuses on the controversies that have characterized PHAS' work with reference to risk assessments, facemasks, voluntarism, testing, and the protection of the elderly during the pandemic. Overall, this inquiry demonstrates that PHAS' risk assessments were initially overly optimistic and their facemask recommendations in conflict with large segments of the scientific community for an extensive period. Yet, their voluntary measures worked moderately well. In their testing, PHAS did not manage to deliver on their promises in time, whereas several measures implemented to protect the elderly were deemed inadequate and late.", "doi": "10.1002/wmh3.449", "pmid": "34226854", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "WMH3449"}, {"db": "pmc", "key": "PMC8242624"}], "notes": [], "created": "2021-08-06T08:41:14.004Z", "modified": "2021-08-06T08:41:14.062Z"}, {"entity": "publication", "iuid": "76bb2203fc7645e5aeeef5beca15a690", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76bb2203fc7645e5aeeef5beca15a690.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76bb2203fc7645e5aeeef5beca15a690"}}, "title": "Abrupt termination of the 2019/20 influenza season following preventive measures against COVID-19 in Denmark, Norway and Sweden", "authors": [{"family": "Emborg", "given": "Hanne Dorthe", "initials": "HD"}, {"family": "Carnahan", "given": "AnnaSara", "initials": "A"}, {"family": "Bragstad", "given": "Karoline", "initials": "K"}, {"family": "Trebbien", "given": "Ramona", "initials": "R"}, {"family": "Brytting", "given": "Mia", "initials": "M"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "Bystr\u00f6m", "given": "Emma", "initials": "E"}, {"family": "Vestergaard", "given": "Lasse S", "initials": "LS"}], "type": "journal-article", "published": "2021-06-03", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "22", "pages": null}, "abstract": null, "doi": "10.2807/1560-7917.es.2021.26.22.2001160", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-07T05:45:38.163Z", "modified": "2021-07-14T09:16:46.478Z"}, {"entity": "publication", "iuid": "60d0fffeda024af68146b7ddfb088951", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60d0fffeda024af68146b7ddfb088951.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60d0fffeda024af68146b7ddfb088951"}}, "title": "Symptoms of Depression and Anxiety During the Early Phase of the COVID-19 Pandemic in Sweden.", "authors": [{"family": "Rondung", "given": "Elisabet", "initials": "E"}, {"family": "Leiler", "given": "Anna", "initials": "A"}, {"family": "Meurling", "given": "Jennifer", "initials": "J"}, {"family": "Bj\u00e4rt\u00e5", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-06-02", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "562437", "issn-l": "2296-2565"}, "abstract": "In this cross-sectional study we aimed to assess symptoms of depression and anxiety at an early stage of the COVID-19 pandemic, and to explore factors predictive of these mental health outcomes. A sample of 1,503 participants, recruited from the general Swedish population, completed an online survey distributed through social media. In this sample, 22.2% reported clinically significant levels of depressive symptoms (PHQ-9 \u2265 10) and 10.9% indicated possible major depression using the PHQ-9 algorithm. Moreover, 28.3% reported clinically significant levels of anxiety (GAD-7 \u2265 8) and 9.7% severe anxiety and possible GAD (GAD-7 \u2265 15). Multiple linear regression analyses identified some common predictors for both outcomes. Age, having a stable income, and sufficient social stimulation, sleep, and recovery showed negative associations, whereas worry about the economy and overall burden showed positive associations. These results suggest an impact on mental health already at an early stage of the COVID-19 pandemic.", "doi": "10.3389/fpubh.2021.562437", "pmid": "34150691", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8206505"}], "notes": [], "created": "2021-06-28T18:23:49.877Z", "modified": "2023-01-13T14:44:35.901Z"}, {"entity": "publication", "iuid": "c3b94717e04649e1b6097a9f0472e679", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3b94717e04649e1b6097a9f0472e679.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3b94717e04649e1b6097a9f0472e679"}}, "title": "SARS-CoV-2 in hospital indoor environments is predominantly non-infectious.", "authors": [{"family": "Krambrich", "given": "Janina", "initials": "J"}, {"family": "Akaberi", "given": "Dario", "initials": "D"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Svensson", "given": "Lennart", "initials": "L"}, {"family": "Hagbom", "given": "Marie", "initials": "M"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "journal article", "published": "2021-06-02", "journal": {"title": "Virol J", "issn": "1743-422X", "issn-l": null, "volume": "18", "issue": "1", "pages": "109"}, "abstract": "The ongoing SARS-CoV-2 pandemic has spread rapidly worldwide and disease prevention is more important than ever. In the absence of a vaccine, knowledge of the transmission routes and risk areas of infection remain the most important existing tools to prevent further spread.\r\n\r\nHere we investigated the presence of the SARS-CoV-2 virus in the hospital environment at the Uppsala University Hospital Infectious Disease ward by RT-qPCR and determined the infectivity of the detected virus in vitro on Vero E6 cells.\r\n\r\nSARS-CoV-2 RNA was detected in several areas, although attempts to infect Vero E6 cells with positive samples were unsuccessful. However, RNase A treatment of positive samples prior to RNA extraction did not degrade viral RNA, indicating the presence of SARS-CoV-2 nucleocapsids or complete virus particles protecting the RNA as opposed to free viral RNA.\r\n\r\nOur results show that even in places where a moderate concentration (Ct values between 30 and 38) of SARS-CoV-2 RNA was found; no infectious virus could be detected. This suggests that the SARS-CoV-2 virus in the hospital environment subsides in two states; as infectious and as non-infectious. Future work should investigate the reasons for the non-infectivity of SARS-CoV-2 virions.", "doi": "10.1186/s12985-021-01556-6", "pmid": "34078386", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Category: Health": null, "Research Area: High-throughput and high-content serology": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12985-021-01556-6"}, {"db": "URL", "key": "https://static-content.springer.com/esm/art%3A10.1186%2Fs12985-021-01556-6/MediaObjects/12985_2021_1556_MOESM1_ESM.pdf", "description": "Ct values for all collected samples at the Uppsala University infectious disease ward"}], "notes": [], "created": "2021-06-04T11:04:45.124Z", "modified": "2021-08-25T08:17:42.781Z"}, {"entity": "publication", "iuid": "46e6889db97c4af2be73b1e55efe3b6d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46e6889db97c4af2be73b1e55efe3b6d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46e6889db97c4af2be73b1e55efe3b6d"}}, "title": "Point of care ultrasound screening for deep vein thrombosis in critically ill COVID-19 patients, an observational study.", "authors": [{"family": "Galien", "given": "Sarah", "initials": "S"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Stattin", "given": "Karl", "initials": "K"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Ros\u00e9n", "given": "Jacob", "initials": "J"}, {"family": "Uppsala Intensive Care COVID-19 Research Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-06-02", "journal": {"title": "Thromb J", "issn": "1477-9560", "issn-l": null, "volume": "19", "issue": "1", "pages": "38"}, "abstract": "Deep vein thrombosis (DVT) is common in critically ill patients with Coronavirus disease 2019 (COVID-19) and may cause fatal pulmonary embolism (PE) prior to diagnosis due to subtle clinical symptoms. The aim of this study was to explore the feasibility of bedside screening for DVT in critically ill COVID-19 patients performed by physicians with limited experience of venous ultrasound. We further aimed to compare inflammation, coagulation and organ dysfunction in patients with and without venous thromboembolism (VTE).\r\n\r\nThis observational study included patients with COVID-19 admitted to the intensive care unit (ICU) of a tertiary hospital in Sweden and screened for DVT with proximal compression ultrasound of the lower extremities between April and July 2020. Screening was performed by ICU residents having received a short online education and one hands-on-session. Pathological screening ultrasound was confirmed by formal ultrasound whereas patients with negative screening underwent formal ultrasound on clinical suspicion. Clinical data, laboratory findings and follow-up were extracted from medical records.\r\n\r\nOf 90 eligible patients, 56 were screened by seven ICU residents with no (n = 5) or limited (n = 2) previous experience of DVT ultrasound who performed a median of 4 (IQR 2-19) examinations. Four (7.1%) patients had pathological screening ultrasound of which three (5.6%) were confirmed by formal ultrasound. None of the 52 patients with negative screening ultrasound were diagnosed with DVT during follow-up. Six patients were diagnosed with PE of which four prior to negative screening and two following negative and positive screening respectively. Patients with VTE (n = 8) had higher median peak D-dimer (24.0 (IQR 14.2-50.5) vs. 2.8 (IQR 1.7-7.2) mg/L, p = 0.004), mean peak C-reactive protein (363 (SD 80) vs. 285 (SD 108) mg/L, p = 0.033) and median peak plasma creatinine (288 (IQR 131-328) vs. 94 (IQR 78-131) \u03bcmol/L, p = 0.009) compared to patients without VTE (n = 48). Five patients (63%) with VTE received continuous renal replacement therapy compared to six patients (13%) without VTE (p = 0.005).\r\n\r\nICU residents with no or limited experience could detect DVT with ultrasound in critically ill COVID-19 patients following a short education. VTE was associated with kidney dysfunction and features of hyperinflammation and hypercoagulation.\r\n\r\nClinicalTrials ID: NCT04316884 . Registered 20 March 2020.", "doi": "10.1186/s12959-021-00272-z", "pmid": "34078399", "labels": {"Type: Journal article": null, "Category: Health": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12959-021-00272-z"}, {"db": "ClinicalTrials.gov", "key": "NCT04316884"}, {"db": "URL", "key": "https://doi.org/10.17044/scilifelab.14229410.v1", "description": "Metadata record"}], "notes": [], "created": "2021-06-04T10:55:06.564Z", "modified": "2021-06-21T14:44:24.986Z"}, {"entity": "publication", "iuid": "c8641609df574656ac6e2104bcdc7fe6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c8641609df574656ac6e2104bcdc7fe6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c8641609df574656ac6e2104bcdc7fe6"}}, "title": "COVID-19 and stem cell transplantation; results from an EBMT and GETH multicenter prospective survey.", "authors": [{"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "de la Camara", "given": "Rafael", "initials": "R"}, {"family": "Mikulska", "given": "Malgorzata", "initials": "M"}, {"family": "Tridello", "given": "Gloria", "initials": "G"}, {"family": "Aguado", "given": "Beatriz", "initials": "B"}, {"family": "Zahrani", "given": "Mohsen Al", "initials": "MA"}, {"family": "Apperley", "given": "Jane", "initials": "J"}, {"family": "Berceanu", "given": "Ana", "initials": "A"}, {"family": "Bofarull", "given": "Rodrigo Martino", "initials": "RM"}, {"family": "Calbacho", "given": "Maria", "initials": "M"}, {"family": "Ciceri", "given": "Fabio", "initials": "F"}, {"family": "Lopez-Corral", "given": "Lucia", "initials": "L"}, {"family": "Crippa", "given": "Claudia", "initials": "C"}, {"family": "Fox", "given": "Maria Laura", "initials": "ML"}, {"family": "Grassi", "given": "Anna", "initials": "A"}, {"family": "Jimenez", "given": "Maria-Jose", "initials": "MJ"}, {"family": "Demir", "given": "Safiye Ko\u00e7ulu", "initials": "SK"}, {"family": "Kwon", "given": "Mi", "initials": "M"}, {"family": "Llamas", "given": "Carlos Vallejo", "initials": "CV"}, {"family": "Lorenzo", "given": "Jos\u00e9 Luis L\u00f3pez", "initials": "JLL"}, {"family": "Mielke", "given": "Stephan", "initials": "S"}, {"family": "Orchard", "given": "Kim", "initials": "K"}, {"family": "Porras", "given": "Rocio Parody", "initials": "RP"}, {"family": "Vallisa", "given": "Daniele", "initials": "D"}, {"family": "Xhaard", "given": "Alienor", "initials": "A"}, {"family": "Knelange", "given": "Nina Simone", "initials": "NS"}, {"family": "Cedillo", "given": "Angel", "initials": "A"}, {"family": "Kr\u00f6ger", "given": "Nicolaus", "initials": "N"}, {"family": "Pi\u00f1ana", "given": "Jos\u00e9 Luis", "initials": "JL"}, {"family": "Styczynski", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2021-06-02", "journal": {"title": "Leukemia", "issn": "1476-5551", "volume": null, "issue": null, "issn-l": null}, "abstract": "This study reports on 382 COVID-19 patients having undergone allogeneic (n = 236) or autologous (n = 146) hematopoietic cell transplantation (HCT) reported to the European Society for Blood and Marrow Transplantation (EBMT) or to the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH). The median age was 54.1 years (1.0-80.3) for allogeneic, and 60.6 years (7.7-81.6) for autologous HCT patients. The median time from HCT to COVID-19 was 15.8 months (0.2-292.7) in allogeneic and 24.6 months (-0.9 to 350.3) in autologous recipients. 83.5% developed lower respiratory tract disease and 22.5% were admitted to an ICU. Overall survival at 6 weeks from diagnosis was 77.9% and 72.1% in allogeneic and autologous recipients, respectively. Children had a survival of 93.4%. In multivariate analysis, older age (p = 0.02), need for ICU (p < 0.0001) and moderate/high immunodeficiency index (p = 0.04) increased the risk while better performance status (p = 0.001) decreased the risk for mortality. Other factors such as underlying diagnosis, time from HCT, GVHD, or ongoing immunosuppression did not significantly impact overall survival. We conclude that HCT patients are at high risk of developing LRTD, require admission to ICU, and have increased mortality in COVID-19.", "doi": "10.1038/s41375-021-01302-5", "pmid": "34079042", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41375-021-01302-5"}], "notes": [], "created": "2021-06-04T08:14:17.305Z", "modified": "2021-06-04T10:54:25.197Z"}, {"entity": "publication", "iuid": "a2c82a2f8756499cb454bd4e2cd18144", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2c82a2f8756499cb454bd4e2cd18144.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2c82a2f8756499cb454bd4e2cd18144"}}, "title": "A global analysis of the impact of COVID-19 stay-at-home restrictions on crime.", "authors": [{"family": "Nivette", "given": "Amy E", "initials": "AE"}, {"family": "Zahnow", "given": "Renee", "initials": "R"}, {"family": "Aguilar", "given": "Raul", "initials": "R"}, {"family": "Ahven", "given": "Andri", "initials": "A"}, {"family": "Amram", "given": "Shai", "initials": "S"}, {"family": "Ariel", "given": "Barak", "initials": "B"}, {"family": "Burbano", "given": "Mar\u00eda Jos\u00e9 Arosemena", "initials": "MJA"}, {"family": "Astolfi", "given": "Roberta", "initials": "R"}, {"family": "Baier", "given": "Dirk", "initials": "D"}, {"family": "Bark", "given": "Hyung-Min", "initials": "H"}, {"family": "Beijers", "given": "Joris E H", "initials": "JEH"}, {"family": "Bergman", "given": "Marcelo", "initials": "M"}, {"family": "Breetzke", "given": "Gregory", "initials": "G"}, {"family": "Concha-Eastman", "given": "I Alberto", "initials": "IA"}, {"family": "Curtis-Ham", "given": "Sophie", "initials": "S"}, {"family": "Davenport", "given": "Ryan", "initials": "R"}, {"family": "D\u00edaz", "given": "Carlos", "initials": "C"}, {"family": "Fleitas", "given": "Diego", "initials": "D"}, {"family": "Gerell", "given": "Manne", "initials": "M"}, {"family": "Jang", "given": "Kwang-Ho", "initials": "K"}, {"family": "K\u00e4\u00e4ri\u00e4inen", "given": "Juha", "initials": "J"}, {"family": "Lappi-Sepp\u00e4l\u00e4", "given": "Tapio", "initials": "T"}, {"family": "Lim", "given": "Woon-Sik", "initials": "W"}, {"family": "Revilla", "given": "Rosa Loureiro", "initials": "RL"}, {"family": "Mazerolle", "given": "Lorraine", "initials": "L"}, {"family": "Me\u0161ko", "given": "Gorazd", "initials": "G"}, {"family": "Pereda", "given": "Noem\u00ed", "initials": "N"}, {"family": "Peres", "given": "Maria F T", "initials": "MFT"}, {"family": "Poblete-Cazenave", "given": "Rub\u00e9n", "initials": "R"}, {"family": "Rose", "given": "Simon", "initials": "S"}, {"family": "Svensson", "given": "Robert", "initials": "R"}, {"family": "Trajtenberg", "given": "Nico", "initials": "N"}, {"family": "van der Lippe", "given": "Tanja", "initials": "T"}, {"family": "Veldkamp", "given": "Joran", "initials": "J"}, {"family": "Perdomo", "given": "Carlos J Vilalta", "initials": "CJV"}, {"family": "Eisner", "given": "Manuel P", "initials": "MP"}], "type": "journal article", "published": "2021-06-02", "journal": {"title": "Nat Hum Behav", "issn": "2397-3374", "issn-l": "2397-3374", "volume": null, "issue": null, "pages": null}, "abstract": "The stay-at-home restrictions to control the spread of COVID-19 led to unparalleled sudden change in daily life, but it is unclear how they affected urban crime globally. We collected data on daily counts of crime in 27 cities across 23 countries in the Americas, Europe, the Middle East and Asia. We conducted interrupted time series analyses to assess the impact of stay-at-home restrictions on different types of crime in each city. Our findings show that the stay-at-home policies were associated with a considerable drop in urban crime, but with substantial variation across cities and types of crime. Meta-regression results showed that more stringent restrictions over movement in public space were predictive of larger declines in crime.", "doi": "10.1038/s41562-021-01139-z", "pmid": "34079096", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41562-021-01139-z"}], "notes": [], "created": "2021-06-04T11:41:59.417Z", "modified": "2022-11-23T08:59:40.855Z"}, {"entity": "publication", "iuid": "59678e2f49ae4b0eaf262ea1fb91a031", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/59678e2f49ae4b0eaf262ea1fb91a031.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/59678e2f49ae4b0eaf262ea1fb91a031"}}, "title": "Electrolyte and acid-base imbalance in severe COVID-19.", "authors": [{"family": "Sj\u00f6str\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Rysz", "given": "Susanne", "initials": "S"}, {"family": "Sj\u00f6str\u00f6m", "given": "Henrik", "initials": "H"}, {"family": "H\u00f6ybye", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2021-06-01", "journal": {"title": "Endocr Connect", "issn": "2049-3614", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Acute systemic diseases, such as severe infections, can lead to electrolyte and acid-base alterations. To study the presence of electrolyte imbalance in severe COVID-19, we investigated the frequency and consequences of changes in electrolyte and acid-base patterns over time. We performed a retrospective cohort study including 406 patients with severe COVID-19. Levels of electrolytes, base excess, pH, serum osmolality and hematocrit, the first two weeks of hospitalization, were collected daily from the laboratory database and clinical data from patients' medical records. We found that hyponatremia was present in 57% of the patients at admission and hypernatremia in 2%. However, within two weeks of hospitalization 42% of the patients developed hypernatremia, more frequently in critically ill patients. Lower levels of sodium and potassium at admission was associated with need of mechanical ventilation. Decreased pH at admission was associated with both death and need of mechanical ventilation. Hypernatremia in the ICU was combined with rising base excess and a higher pH. In the group without intensive care, potassium levels was significantly lower in the patients with severe hypernatremia. Presence of hypernatremia during the first two weeks of hospitalization was associated with 3.942 (95% CI 2.269-6.851) times higher odds of death. In summary, hypernatremia was common and associated with longer hospital stay and a higher risk of death, suggesting that the dynamics of sodium is an important indicator of severity in COVID-19.", "doi": "10.1530/EC-21-0265", "pmid": "34156969", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "EC-21-0265"}], "notes": [], "created": "2021-06-28T18:22:10.843Z", "modified": "2021-06-28T18:22:24.253Z"}, {"entity": "publication", "iuid": "445e48b49c1846c780e1e603c3a4769a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/445e48b49c1846c780e1e603c3a4769a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/445e48b49c1846c780e1e603c3a4769a"}}, "title": "Colloidal dispersion of poly(ionic liquid)/Cu composite particles for protective surface coating against SAR-CoV-2.", "authors": [{"family": "Khorsand Kheirabad", "given": "Atefeh", "initials": "A"}, {"family": "Pan", "given": "Xuefeng", "initials": "X"}, {"family": "Long", "given": "Siwen", "initials": "S"}, {"family": "Kochovski", "given": "Zdravko", "initials": "Z"}, {"family": "Zhou", "given": "Shiqi", "initials": "S"}, {"family": "Lu", "given": "Yan", "initials": "Y"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Yuan", "given": "Jiayin", "initials": "J"}], "type": "journal article", "published": "2021-06-01", "journal": {"title": "Nano Sel", "issn": "2688-4011", "issn-l": null}, "abstract": "Herein, we report a waterproof anti-SARS-CoV-2 protective film prepared by spray-coating of an aqueous colloidal dispersion of poly(ionic liquid)/copper (PIL/Cu) composite nanoparticles onto a substrate. The PIL dispersion was prepared by suspension polymerization of 3-dodecyl-1-vinylimdiazolium bromide in water at 70\u00b0C. The copper acetate salt was added into the PIL nanoparticle dispersion and in situ reduced into copper nanoparticles anchoring onto the PIL nanoparticles. Despite being waterborne, the PIL in bulk is intrinsically insoluble in water and the formed coating is stable in water. The formed surface coating by PIL/copper composite nanoparticles was able to deactivate SARS-CoV-2 virions by 90.0% in 30 minutes and thus may effectively prevent the spread of SARS-CoV-2 through surface contact. This method may provide waterborne dispersions for a broad range of antivirus protective surface coatings for both outdoor and indoor applications.", "doi": "10.1002/nano.202100069", "pmid": "34485979", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "NANO202100069"}, {"db": "pmc", "key": "PMC8242609"}], "notes": [], "created": "2021-09-09T05:33:55.285Z", "modified": "2021-09-09T05:34:12.458Z"}, {"entity": "publication", "iuid": "45136e9ac839441891070f8397ec88a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/45136e9ac839441891070f8397ec88a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/45136e9ac839441891070f8397ec88a0"}}, "title": "Tracheotomy in COVID-19 patients: A retrospective study on complications and timing.", "authors": [{"family": "Pauli", "given": "Nina", "initials": "N", "orcid": "0000-0002-4058-2477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42734bf19ccc426986c4c7360d467655.json"}}, {"family": "Eeg-Olofsson", "given": "M\u00e5ns", "initials": "M"}, {"family": "Bergquist", "given": "Henrik", "initials": "H"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Laryngoscope Investig Otolaryngol", "issn": "2378-8038", "volume": "6", "issue": "3", "pages": "446-452", "issn-l": null}, "abstract": "The aim of this study was to analyze the timing of tracheotomy and the duration of mechanical ventilation and stay in the intensive care unit (ICU) in patients with COVID-19 infection. Furthermore, we aimed to investigate tracheotomy complications and mortality.\n\nConsecutive patients with COVID-19 infection admitted to the Department of Infectious Diseases in Gothenburg, Sweden were identified. Medical records were retrieved and retrospectively assessed.\n\nOne hundred eighty-eight patients with COVID-19 infection requiring hospital care were identified. Of these, 116 patients were critically ill and intubated, and 55 patients underwent tracheotomy. The mean time from endotracheal intubation to tracheotomy was 12 days (range 5-28 days). There was a correlation between the timing of tracheotomy and the duration of mechanical ventilation, where a shorter time between intubation and tracheotomy was correlated with a shorter duration of mechanical ventilation (r .58, P < .001), and a correlation was identified between the timing of tracheotomy and the duration of ICU stay (r .52, P < .001). Perioperative hypoxemia was registered in 9% of tracheotomies performed, whereas postoperative bleeding was observed in 27% of cases, the majority of which were minor.\n\nThis retrospective cohort study indicates that early tracheotomy is related to a reduced need for mechanical ventilation and a shorter duration of stay in the ICU in severe cases of COVID-19 disease. Complications during and after tracheotomy in this specific cohort included risk perioperative hypoxia and postoperative bleeding. Prospective randomized controlled trials would be of value to confirm these findings.\n\n4, Case series.", "doi": "10.1002/lio2.560", "pmid": "34195366", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "LIO2560"}, {"db": "pmc", "key": "PMC8223451"}], "notes": [], "created": "2021-07-05T14:30:43.050Z", "modified": "2021-07-05T14:30:43.104Z"}, {"entity": "publication", "iuid": "e851543e1e4e4893aeb160d7e7db8ac5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e851543e1e4e4893aeb160d7e7db8ac5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e851543e1e4e4893aeb160d7e7db8ac5"}}, "title": "Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study.", "authors": [{"family": "COVIDSurg Collaborative", "given": "", "initials": ""}, {"family": "GlobalSurg Collaborative", "given": "", "initials": ""}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Anaesthesia", "issn": "1365-2044", "issn-l": "0003-2409", "volume": "76", "issue": "6", "pages": "748-758"}, "abstract": "Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre-operative SARS-CoV-2 infection were compared with those without previous SARS-CoV-2 infection. The primary outcome measure was 30-day postoperative mortality. Logistic regression models were used to calculate adjusted 30-day mortality rates stratified by time from diagnosis of SARS-CoV-2 infection to surgery. Among 140,231 patients (116 countries), 3127 patients (2.2%) had a pre-operative SARS-CoV-2 diagnosis. Adjusted 30-day mortality in patients without SARS-CoV-2 infection was 1.5% (95%CI 1.4-1.5). In patients with a pre-operative SARS-CoV-2 diagnosis, mortality was increased in patients having surgery within 0-2 weeks, 3-4 weeks and 5-6 weeks of the diagnosis (odds ratio (95%CI) 4.1 (3.3-4.8), 3.9 (2.6-5.1) and 3.6 (2.0-5.2), respectively). Surgery performed \u2265 7 weeks after SARS-CoV-2 diagnosis was associated with a similar mortality risk to baseline (odds ratio (95%CI) 1.5 (0.9-2.1)). After a \u2265 7 week delay in undertaking surgery following SARS-CoV-2 infection, patients with ongoing symptoms had a higher mortality than patients whose symptoms had resolved or who had been asymptomatic (6.0% (95%CI 3.2-8.7) vs. 2.4% (95%CI 1.4-3.4) vs. 1.3% (95%CI 0.6-2.0), respectively). Where possible, surgery should be delayed for at least 7 weeks following SARS-CoV-2 infection. Patients with ongoing symptoms \u2265 7 weeks from diagnosis may benefit from further delay.", "doi": "10.1111/anae.15458", "pmid": "33690889", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8206995"}], "notes": [], "created": "2021-03-17T12:29:40.454Z", "modified": "2023-06-19T15:14:42.544Z"}, {"entity": "publication", "iuid": "e1d3160ba88043cb8f709061c798b507", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e1d3160ba88043cb8f709061c798b507.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e1d3160ba88043cb8f709061c798b507"}}, "title": "The impact of COVID-19 pandemic on vascular registries and clinical trials.", "authors": [{"family": "Aziz", "given": "Faisal", "initials": "F"}, {"family": "Behrendt", "given": "Christian-Alexander", "initials": "CA"}, {"family": "Sullivan", "given": "Kaity", "initials": "K"}, {"family": "Beck", "given": "Adam W", "initials": "AW"}, {"family": "Beiles", "given": "C Barry", "initials": "CB"}, {"family": "Boyle", "given": "Jon R", "initials": "JR"}, {"family": "Mani", "given": "Kevin", "initials": "K"}, {"family": "Benson", "given": "Ruth A", "initials": "RA"}, {"family": "Wohlauer", "given": "Max V", "initials": "MV"}, {"family": "Khashram", "given": "Manar", "initials": "M"}, {"family": "Jorgensen", "given": "Jens Eldrup", "initials": "JE"}, {"family": "Lemmon", "given": "Gary W", "initials": "GW"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Semin Vasc Surg", "issn": "1558-4518", "volume": "34", "issue": "2", "pages": "28-36", "issn-l": null}, "abstract": "Quality improvement programs and clinical trial research experienced disruption due to the coronavirus disease 2019 (COVID-19) pandemic. Vascular registries showed an immediate impact with significant declines in second-quarter vascular procedure volumes witnessed across Europe and the United States. To better understand the magnitude and impact of the pandemic, organizations and study groups sent grass roots surveys to vascular specialists for needs assessment. Several vascular registries responded quickly by insertion of COVID-19 variables into their data collection forms. More than 80% of clinical trials have been reported delayed or not started due to factors that included loss of enrollment from patient concerns or mandated institutional shutdowns, weighing the risk of trial participation on patient safety. Preliminary data of patients undergoing vascular surgery with active COVID-19 infection show inferior outcomes (morbidity) and increased mortality. Disease-specific vascular surgery study collaboratives about COVID-19 were created for the desire to study the disease in a more focused manner than possible through registry outcomes. This review describes the pandemic effect on multiple VASCUNET registries including Germany (GermanVasc), Sweden (SwedVasc), United Kingdom (UK National Vascular Registry), Australia and New Zealand (bi-national Australasian Vascular Audit), as well as the United States (Society for Vascular Surgery Vascular Quality Initiative). We will highlight the continued collaboration of VASCUNET with the Vascular Quality Initiative in the International Consortium of Vascular Registries as part of the Medical Device Epidemiology Network coordinated registry network. Vascular registries must remain flexible and responsive to new and future real-world problems affecting vascular patients.", "doi": "10.1053/j.semvascsurg.2021.04.001", "pmid": "34144744", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0895-7967(21)00025-9"}, {"db": "pmc", "key": "PMC8137351"}], "notes": [], "created": "2021-06-28T18:29:11.034Z", "modified": "2021-06-28T18:29:11.056Z"}, {"entity": "publication", "iuid": "0ce9c878343748629bbc7bda9bcda93a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ce9c878343748629bbc7bda9bcda93a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ce9c878343748629bbc7bda9bcda93a"}}, "title": "The impact of COVID-19 lockdown on dengue transmission in Sri Lanka; A natural experiment for understanding the influence of human mobility.", "authors": [{"family": "Liyanage", "given": "Prasad", "initials": "P", "orcid": "0000-0002-5174-7644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bee7bfe3b6e2476b8337f0c22925a874.json"}}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J", "orcid": "0000-0003-4030-0449", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5f15a200e614e10a8d972285750e745.json"}}, {"family": "Tissera", "given": "Hasitha Aravinda", "initials": "HA", "orcid": "0000-0002-9379-1002", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8bcd2f470e2f4dfcb5bbd2a1b8b50b26.json"}}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "PLoS Negl Trop Dis", "issn": "1935-2735", "issn-l": null, "volume": "15", "issue": "6", "pages": "e0009420"}, "abstract": "Dengue is one of the major public health problems in Sri Lanka. Its outbreak pattern depends on a multitude of drivers, including human mobility. Here we evaluate the impact of COVID-19 related mobility restriction (lockdown) on the risk of dengue in Sri Lanka.\n\nTwo-stage hierarchical models were fitted using an interrupted time-series design based on the notified dengue cases, January 2015 to July 2020. In the first stage model, the district level impact was estimated using quasi-Poisson regression models while accounting for temporal trends. Estimates were pooled at zonal and national levels in the second stage model using meta-analysis. The influence of the extended period of school closure on dengue in children in the western province was compared to adults.\n\nStatistically significant and homogeneous reduction of dengue risk was observed at all levels during the lockdown. Overall an 88% reduction in risk (RR 0.12; 95% CI from 0.08 to 0.17) was observed at the national level. The highest impact was observed among children aged less than 19 years showing a 92% reduction (RR 0.8; 95% CI from 0.03 to 0.25). We observed higher impact in the dry zone having 91% reduction (RR 0.09; 95% CI from 0.05 to 0.15) compared to wet zone showing 83% reduction (RR 0.17; 95% CI from 0.09 to 0.30). There was no indication that the overall health-seeking behaviour for dengue had a substantial influence on these estimates.\n\nThis study offers a broad understanding of the change in risk of dengue during the COVID-19 pandemic and associated mobility restrictions in Sri Lanka. The analysis using the mobility restrictions as a natural experiment suggests mobility patterns to be a very important driver of dengue transmission.", "doi": "10.1371/journal.pntd.0009420", "pmid": "34111117", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8192006"}, {"db": "pii", "key": "PNTD-D-20-02142"}], "notes": [], "created": "2021-06-11T05:04:37.672Z", "modified": "2023-06-19T15:04:40.021Z"}, {"entity": "publication", "iuid": "153dd3f5eadd46babafb9997a4ebe1ba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/153dd3f5eadd46babafb9997a4ebe1ba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/153dd3f5eadd46babafb9997a4ebe1ba"}}, "title": "The SIOG COVID-19 working group recommendations on the rollout of COVID-19 vaccines among older adults with cancer.", "authors": [{"family": "Mislang", "given": "Anna Rachelle", "initials": "AR"}, {"family": "Soto-Perez-de-Celis", "given": "Enrique", "initials": "E"}, {"family": "Russo", "given": "Chiara", "initials": "C"}, {"family": "Colloca", "given": "Giuseppe", "initials": "G"}, {"family": "Williams", "given": "Grant R", "initials": "GR"}, {"family": "O'Hanlon", "given": "Shane", "initials": "S"}, {"family": "Cooper", "given": "Lisa", "initials": "L"}, {"family": "O'Donovan", "given": "Anita", "initials": "A"}, {"family": "Audisio", "given": "Riccardo A", "initials": "RA"}, {"family": "Cheung", "given": "Kwok-Leung", "initials": "KL"}, {"family": "Sarri\u00f3", "given": "Regina Giron\u00e9s", "initials": "RG"}, {"family": "Stauder", "given": "Reinhard", "initials": "R"}, {"family": "Jaklitsch", "given": "Michael", "initials": "M"}, {"family": "Cairo", "given": "Clarito", "initials": "C"}, {"family": "Gil", "given": "Luiz Antonio", "initials": "LA"}, {"family": "Sattar", "given": "Schroder", "initials": "S"}, {"family": "Kantilal", "given": "Kumud", "initials": "K"}, {"family": "Loh", "given": "Kah Poh", "initials": "KP"}, {"family": "Lichtman", "given": "Stuart M", "initials": "SM"}, {"family": "Brain", "given": "Etienne", "initials": "E"}, {"family": "Wildiers", "given": "Hans", "initials": "H"}, {"family": "Kanesvaran", "given": "Ravindran", "initials": "R"}, {"family": "Battisti", "given": "Nicol\u00f2 Matteo Luca", "initials": "NML"}], "type": "letter", "published": "2021-06-00", "journal": {"title": "J Geriatr Oncol", "issn": "1879-4076", "volume": "12", "issue": "5", "pages": "848-850", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jgo.2021.03.003", "pmid": "33715995", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1879-4068(21)00057-6"}, {"db": "pmc", "key": "PMC7934668"}], "notes": [], "created": "2021-03-17T07:13:04.746Z", "modified": "2021-11-18T12:48:50.459Z"}, {"entity": "publication", "iuid": "cb5b53f903dd43ac81c6315419c96fe0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cb5b53f903dd43ac81c6315419c96fe0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cb5b53f903dd43ac81c6315419c96fe0"}}, "title": "The New Totalitarians: The Swedish COVID-19 strategy and the implications of consensus culture and media policy for public health.", "authors": [{"family": "Lindstr\u00f6m", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "SSM Popul Health", "issn": "2352-8273", "issn-l": null, "volume": "14", "issue": null, "pages": "100788"}, "abstract": "The aim is to discuss implications of consensus culture in combination with media policy in Sweden with regard to the Swedish COVID-19 strategy in the spring of 2020.\r\n\r\nInvestigation of prerequisites for scrutiny by the Swedish mass media of the Swedish strategy in the spring of 2020 based on discussion regarding consensus culture, media structure and postmodernism in science, politics and administration.\r\n\r\nThe Swedish strategy entailed strong initial confidence in herd immunity (although not officially stated), individual responsibility, evidence based medicine and substantial neglect to cooperate internationally. The strategy may be regarded partly as a result of the postmodern view of science and society predominant in Sweden. A tradition of top down consensus culture combined with mass media's financial and partly structural dependence of the state may help explain the comparative lack of critical questions regarding the strategy at the press conferences in the spring of 2020.\r\n\r\nMass media in Sweden should become more financially and structurally independent of the state. The reporting by Swedish media in the spring of 2020 should be subject to peer-reviewed research.", "doi": "10.1016/j.ssmph.2021.100788", "pmid": "34136630", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2352-8273(21)00063-X"}, {"db": "pmc", "key": "PMC8182112"}], "notes": [], "created": "2021-06-28T18:41:53.111Z", "modified": "2021-07-14T09:09:06.291Z"}, {"entity": "publication", "iuid": "db4f6196f40a4023837567fb80842949", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db4f6196f40a4023837567fb80842949.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db4f6196f40a4023837567fb80842949"}}, "title": "T cell immunity to SARS-CoV-2.", "authors": [{"family": "Niessl", "given": "Julia", "initials": "J"}, {"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Semin Immunol", "issn": "1096-3618", "pages": "101505", "volume": "55", "issn-l": null}, "abstract": "Exceptional efforts have been undertaken to shed light into the biology of adaptive immune responses to SARS-CoV-2. T cells occupy a central role in adaptive immunity to mediate helper functions to different arms of the immune system and are fundamental to mediate protection, control, and clearance of most viral infections. Even though many questions remain unsolved, there is a growing literature linking specific T cell characteristics to differential COVID-19 severity and vaccine outcome. In this review, we summarize our current understanding of CD4+ and CD8+ T cell responses in acute and convalescent COVID-19. Further, we discuss the T cell literature coupled to pre-existing immunity and vaccines and highlight the need to look beyond blood to fully understand how T cells function in the tissue space.", "doi": "10.1016/j.smim.2021.101505", "pmid": "34711489", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8529278"}, {"db": "pii", "key": "S1044-5323(21)00036-1"}], "notes": [], "created": "2021-11-01T19:51:00.402Z", "modified": "2023-01-13T13:25:49.721Z"}, {"entity": "publication", "iuid": "63d6d2d5319f47f4894f5efeed7eef39", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63d6d2d5319f47f4894f5efeed7eef39.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63d6d2d5319f47f4894f5efeed7eef39"}}, "title": "Sleep problems during COVID-19 pandemic and its' association to psychological distress: A systematic review and meta-analysis.", "authors": [{"family": "Alimoradi", "given": "Zainab", "initials": "Z"}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Tsang", "given": "Hector W H", "initials": "HWH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Haghayegh", "given": "Shahab", "initials": "S"}, {"family": "Ohayon", "given": "Maurice M", "initials": "MM"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "issn-l": null, "volume": "36", "issue": null, "pages": "100916"}, "abstract": "The emerging novel coronavirus disease 2019 (COVID-19) has become one of the leading cause of deaths worldwide in 2020. The present systematic review and meta-analysis estimated the magnitude of sleep problems during the COVID-19 pandemic and its relationship with psychological distress.\r\n\r\nFive academic databases ( Scopus, PubMed Central, ProQuest, ISI Web of Knowledge, and Embase) were searched. Observational studies including case-control studies and cross-sectional studies were included if relevant data relationships were reported (i.e., sleep assessed utilizing the Pittsburgh Sleep Quality Index or Insomnia Severity Index). All the studies were English, peer-reviewed papers published between December 2019 and February 2021. PROSPERO registration number: CRD42020181644.\r\n\r\n168 cross-sectional, four case-control, and five longitudinal design papers comprising 345,270 participants from 39 countries were identified. The corrected pooled estimated prevalence of sleep problems were 31% among healthcare professionals, 18% among the general population, and 57% among COVID-19 patients (all p-values < 0.05). Sleep problems were associated with depression among healthcare professionals, the general population, and COVID-19 patients, with Fisher's Z scores of -0.28, -0.30, and -0.36, respectively. Sleep problems were positively (and moderately) associated with anxiety among healthcare professionals, the general population, and COVID-19 patients, with Fisher's z scores of 0.55, 0.48, and 0.49, respectively.\r\n\r\nSleep problems appear to have been common during the ongoing COVID-19 pandemic. Moreover, sleep problems were found to be associated with higher levels of psychological distress. With the use of effective programs treating sleep problems, psychological distress may be reduced. Vice versa, the use of effective programs treating psychological distress, sleep problems may be reduced.\r\n\r\nThe present study received no funding.", "doi": "10.1016/j.eclinm.2021.100916", "pmid": "34131640", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(21)00196-6"}, {"db": "pmc", "key": "PMC8192091"}], "notes": [], "created": "2021-06-17T07:35:43.630Z", "modified": "2021-07-14T09:12:28.694Z"}, {"entity": "publication", "iuid": "fc24ed82a6ff4d4ca6ec337815354701", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc24ed82a6ff4d4ca6ec337815354701.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc24ed82a6ff4d4ca6ec337815354701"}}, "title": "Response by Mackman et al to Letter Regarding Article, \"Patients With COVID-19 Have Elevated Levels of Circulating Extracellular Vesicle Tissue Factor Activity That Is Associated With Severity and Mortality-Brief Report\".", "authors": [{"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Hisada", "given": "Yohei", "initials": "Y"}, {"family": "Grover", "given": "Steven P", "initials": "SP"}, {"family": "Rosell", "given": "Axel", "initials": "A"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "von Meijenfeldt", "given": "Fien", "initials": "F"}, {"family": "Aguilera", "given": "Katherina", "initials": "K"}, {"family": "Lisman", "given": "Ton", "initials": "T"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "letter", "published": "2021-06-00", "journal": {"title": "Arterioscler Thromb Vasc Biol", "issn": "1524-4636", "volume": "41", "issue": "6", "pages": "e381-e382", "issn-l": null}, "abstract": null, "doi": "10.1161/ATVBAHA.121.316203", "pmid": "34038165", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-29T15:33:21.987Z", "modified": "2021-05-29T15:33:21.996Z"}, {"entity": "publication", "iuid": "bd5c6eab824541e4a1713a503582837f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bd5c6eab824541e4a1713a503582837f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bd5c6eab824541e4a1713a503582837f"}}, "title": "Rehabilitation needs and mortality associated with the Covid-19 pandemic: a population-based study of all hospitalised and home-healthcare individuals in a Swedish healthcare region.", "authors": [{"family": "Divanoglou", "given": "Anestis", "initials": "A"}, {"family": "Samuelsson", "given": "Assoc Prof Kersti", "initials": "APK"}, {"family": "Sj\u00f6dahl", "given": "Prof Emer Rune", "initials": "PER"}, {"family": "Andersson", "given": "Christer", "initials": "C"}, {"family": "Levi", "given": "Prof Richard", "initials": "PR"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "issn-l": null, "volume": "36", "issue": null, "pages": "100920"}, "abstract": "This first report of the Link\u00f6ping Covid-19 Study (LinCoS) aimed at determination of Covid-19-associated mortality, impairments, activity and participation limitations denoting rehabilitation needs four months after discharge from hospital.\r\n\r\nAn ambidirectional population-based cohort study including all confirmed Covid-19 cases admitted to hospital during 1/03-31/05 and those living in home healthcare settings identified through a regional registry and evaluated through medical records, including WHO Clinical Progression Scale (CPS). All patients discharged from hospital were followed-up by structured telephone interview at 4 months post-discharge. Respondents indicated any new or aggravated persisting problems in any of 25 body functions and 12 activity/participation items and rated them for impact on daily life.\r\n\r\nOut of 734 hospitalised patients, 149 were excluded, 125 died, and 460 were alive at 4-month follow-up of whom 433 (94.1%) were interviewed. In total, 40% reported impairments and activity/participation limitations affecting daily life and warranted further multi-professional rehabilitation assessment, predominantly those with severe disease and a considerable proportion of those with moderate disease. Cognitive and affective impairments were equally common in all groups and were reported by 20-40% of cases. Limb weakness was reported by 31%, with CPS 7-9 being four times more likely to report this problem as compared to CPS 4-5. 26% of those working or studying reported difficulties returning to these activities, this being 3.5 times more likely in CPS 7-9 as compared to CPS 4-5. 25% reported problems walking >1 km, with CPS 7-9 over three times more likely to report this as compared to the other two sub-groups. 90-day mortality rate of Covid-19 associated deaths was 15.1%.\r\n\r\nMost rehabilitation needs after Covid-19 involved higher cerebral dysfunction both in patients with moderate and severe disease. This should be considered when designing services aiming at minimizing long-term disability.\r\n\r\nALF grant and Region \u00d6sterg\u00f6tland.", "doi": "10.1016/j.eclinm.2021.100920", "pmid": "34095795", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(21)00200-5"}, {"db": "pmc", "key": "PMC8164661"}], "notes": [], "created": "2021-06-08T09:00:47.968Z", "modified": "2021-07-14T09:11:25.676Z"}, {"entity": "publication", "iuid": "85fe5abcf3b7455493fc233a38c9d883", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/85fe5abcf3b7455493fc233a38c9d883.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/85fe5abcf3b7455493fc233a38c9d883"}}, "title": "Proteome profiling of recombinant DNase therapy in reducing NETs and aiding recovery in COVID-19 patients", "authors": [{"family": "Fisher", "given": "Jane", "initials": "J"}, {"family": "Mohanty", "given": "Tirthankar", "initials": "T"}, {"family": "Karlsson", "given": "Christofer", "initials": "C"}, {"family": "Khademi", "given": "S M Hossein", "initials": "SMH"}, {"family": "Malmstr\u00f6m", "given": "Erik", "initials": "E"}, {"family": "Frigyesi", "given": "Attila", "initials": "A"}, {"family": "Nordenfelt", "given": "Pontus", "initials": "P"}, {"family": "Malmstrom", "given": "Johan", "initials": "J"}, {"family": "Linder", "given": "Adam", "initials": "A"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "Molecular & Cellular Proteomics", "issn": "1535-9476", "issn-l": null, "volume": null, "issue": null, "pages": "100113"}, "abstract": "Severe COVID-19 can result in pneumonia and acute respiratory failure. Accumulation of mucus in the airways is a hall mark of the disease and can result in hypoxemia. Here, we show that quantitative proteome analysis of the sputum from severe COVID-19 patients reveal high levels of neutrophil extracellular trap(s) (NETs) components, which was confirmed by microscopy. Extracellular DNA from excessive NET formation can increase sputum viscosity and can lead to acute respiratory distress syndrome (ARDS). Recombinant human DNase (rhDNase/Pulmozyme) has been shown to be beneficial in reducing sputum viscosity and improve lung function. We treated 5 COVID-19 patients presenting acute symptoms with clinically approved aerosolized Pulmozyme. No adverse reactions to the drug were seen, and improved oxygen saturation and recovery in all severely ill COVID-19 patients was observed after therapy. Immunofluorescence and proteome analysis of sputum and blood plasma samples after treatment revealed a marked reduction of NETs and a set of statistically significant proteome changes that indicate reduction of haemorrhage, plasma leakage and inflammation in the airways, and reduced systemic inflammatory state in the blood plasma of patients. Taken together, the results indicate that NETs contribute to acute respiratory failure in COVID-19 and that degrading NETs may reduce dependency on external high flow oxygen therapy in patients. Targeting NETs using rhDNase may have significant therapeutic implications in COVID-19 disease and warrants further studies.", "doi": "10.1016/j.mcpro.2021.100113", "pmid": "34139362", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S1535-9476(21)00085-2"}, {"db": "pmc", "key": "PMC8205261"}, {"db": "PRIDE", "key": "https://www.ebi.ac.uk/pride/archive/projects/PXD021197", "description": "COVID-19 proteome profiling reveals resolution of inflammatory pathways and respiratory distress after DNase treatment"}], "notes": [], "created": "2021-06-28T18:31:04.166Z", "modified": "2021-11-18T13:36:33.841Z"}, {"entity": "publication", "iuid": "a82bd6da695c4af2b35286616494696c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a82bd6da695c4af2b35286616494696c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a82bd6da695c4af2b35286616494696c"}}, "title": "Prevalence of SARS-CoV-2 in Communities Through Wastewater Surveillance\u2014a Potential Approach for Estimation of Disease Burden", "authors": [{"family": "Bhattacharya", "given": "Prosun", "initials": "P", "orcid": "0000-0003-4350-9950", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06f71013630d4ed08a8672a7e86ce6bf.json"}}, {"family": "Kumar", "given": "Manish", "initials": "M"}, {"family": "Islam", "given": "Md Tahmidul", "initials": "MT"}, {"family": "Haque", "given": "Rehnuma", "initials": "R"}, {"family": "Chakraborty", "given": "Sudip", "initials": "S"}, {"family": "Ahmad", "given": "Arslan", "initials": "A"}, {"family": "Niazi", "given": "Nabeel Khan", "initials": "NK"}, {"family": "Cetecioglu", "given": "Zeynep", "initials": "Z"}, {"family": "Nilsson", "given": "David", "initials": "D"}, {"family": "Ijumulana", "given": "Julian", "initials": "J"}, {"family": "van der Voorn", "given": "Tom", "initials": "T"}, {"family": "Jakariya", "given": "Md", "initials": "M"}, {"family": "Hossain", "given": "Maqsud", "initials": "M"}, {"family": "Ahmed", "given": "Firoz", "initials": "F"}, {"family": "Rahman", "given": "Mahbubur", "initials": "M"}, {"family": "Akter", "given": "Nargis", "initials": "N"}, {"family": "Johnston", "given": "Dara", "initials": "D"}, {"family": "Ahmed", "given": "Kazi Matin", "initials": "KM"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "Curr Pollut Rep", "issn": "2198-6592", "issn-l": null, "volume": "7", "issue": "2", "pages": "160-166"}, "abstract": "The episodic outbreak of COVID-19 due to SARS-CoV-2 is severely affecting the economy, and the global count of infected patients is increasing. The actual number of patients had been underestimated due to limited facilities for testing as well as asymptomatic nature of the expression of COVID-19 on individual basis. Tragically, for emerging economies with high population density, the situation has been more complex due to insufficient testing facilities for diagnosis of the disease. However, the recent reports about persistent shedding of viral RNA of SARS-CoV-2 in the human feces have created a possibility to track the prevalence and trends of the disease in communities, known as wastewater-based epidemiology (WBE). In this article, we highlight the current limitations and future prospects for WBE to manage pandemics.", "doi": "10.1007/s40726-021-00178-4", "pmid": "33842197", "labels": {"Research Area: Environmental virus profiling": null, "Funder: KAW/SciLifeLab": null, "Type: Review": null}, "xrefs": [{"db": "pii", "key": "178"}, {"db": "pmc", "key": "PMC8021931"}], "notes": [], "created": "2021-04-13T09:40:35.469Z", "modified": "2021-06-18T08:45:52.985Z"}, {"entity": "publication", "iuid": "f09cc223d49a4f3781c4d702e7d588fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f09cc223d49a4f3781c4d702e7d588fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f09cc223d49a4f3781c4d702e7d588fc"}}, "title": "Preterm Birth and Stillbirth During the COVID-19 Pandemic in Sweden: A Nationwide Cohort Study.", "authors": [{"family": "Pasternak", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-2097-8466", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c3b2692f334845c184219da7da7483d2.json"}}, {"family": "Neovius", "given": "Martin", "initials": "M", "orcid": "0000-0003-2300-3055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78e60d3149ce4ac994ddeaa441514ef6.json"}}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Ahlberg", "given": "Mia", "initials": "M", "orcid": "0000-0001-8612-6277", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4bb9a2d40e1478097dc3a95c6a8c9f3.json"}}, {"family": "Norman", "given": "Mikael", "initials": "M", "orcid": "0000-0003-4191-3781", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5346954396864ffbb8a1380e15c7dba7.json"}}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF", "orcid": "0000-0003-1024-5602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1d5e45881a7469ca20a0eb360d891cc.json"}}, {"family": "Stephansson", "given": "Olof", "initials": "O", "orcid": "0000-0003-1528-4563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39af50356a574c80ba6bd2227ecb5cf5.json"}}], "type": "letter", "published": "2021-06-00", "journal": {"title": "Ann Intern Med", "issn": "1539-3704", "volume": "174", "issue": "6", "pages": "873-875", "issn-l": "0003-4819"}, "abstract": null, "doi": "10.7326/M20-6367", "pmid": "33428442", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7808327"}], "notes": [], "created": "2023-01-05T09:33:03.361Z", "modified": "2023-01-05T09:33:20.337Z"}, {"entity": "publication", "iuid": "ffa3b7d3a56044fc9a89e408e7db2859", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ffa3b7d3a56044fc9a89e408e7db2859.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ffa3b7d3a56044fc9a89e408e7db2859"}}, "title": "Parkinson's Disease and Post-COVID-19 Syndrome: The Parkinson's Long-COVID Spectrum.", "authors": [{"family": "Leta", "given": "Valentina", "initials": "V", "orcid": "0000-0002-5794-7540", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15265d9377c342df8506ee8a06708525.json"}}, {"family": "Rodr\u00edguez-Violante", "given": "Mayela", "initials": "M", "orcid": "0000-0002-6041-9941", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a434345ba2d4075913a2af5b00e318a.json"}}, {"family": "Abundes", "given": "Arturo", "initials": "A"}, {"family": "Rukavina", "given": "Katarina", "initials": "K"}, {"family": "Teo", "given": "James T", "initials": "JT"}, {"family": "Falup-Pecurariu", "given": "Cristian", "initials": "C"}, {"family": "Irincu", "given": "Laura", "initials": "L"}, {"family": "Rota", "given": "Silvia", "initials": "S"}, {"family": "Bhidayasiri", "given": "Roongroj", "initials": "R", "orcid": "0000-0002-6901-2064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78c370775b434ae281b3a0e57367686c.json"}}, {"family": "Storch", "given": "Alexander", "initials": "A"}, {"family": "Odin", "given": "Per", "initials": "P"}, {"family": "Antonini", "given": "Angelo", "initials": "A", "orcid": "0000-0003-1040-2807", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02f966fef60c46a9aa7be04923ea0a2a.json"}}, {"family": "Ray Chaudhuri", "given": "Kallol", "initials": "K", "orcid": "0000-0003-2815-0505", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92bb30651ec5484f8a1364222efcce5a.json"}}], "type": "letter", "published": "2021-06-00", "journal": {"title": "Mov Disord", "issn": "1531-8257", "issn-l": null, "volume": "36", "issue": "6", "pages": "1287-1289"}, "abstract": null, "doi": "10.1002/mds.28622", "pmid": "33890344", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8250675"}], "notes": [], "created": "2021-04-29T16:10:06.261Z", "modified": "2023-01-13T13:24:33.196Z"}, {"entity": "publication", "iuid": "088b14ba53f7445899eef52f4f1addf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/088b14ba53f7445899eef52f4f1addf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/088b14ba53f7445899eef52f4f1addf3"}}, "title": "Orthodontic retention: what's on the horizon?", "authors": [{"family": "Littlewood", "given": "Simon J", "initials": "SJ"}, {"family": "Dalci", "given": "Oyku", "initials": "O"}, {"family": "Dolce", "given": "Calogero", "initials": "C"}, {"family": "Holliday", "given": "L Shannon", "initials": "LS"}, {"family": "Naraghi", "given": "Sasan", "initials": "S"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Br Dent J", "issn": "1476-5373", "volume": "230", "issue": "11", "pages": "760-764", "issn-l": null}, "abstract": "Orthodontic retention remains one of the great challenges in orthodontics. In this article, we discuss what is on the horizon to help address this challenge, including biological approaches to reduce relapse, treating patients without using retainers, technological developments, personalised medicine and the impact of COVID-19 on approaches to orthodontic retention.", "doi": "10.1038/s41415-021-2937-8", "pmid": "34117435", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41415-021-2937-8"}], "notes": [], "created": "2021-06-14T06:33:28.931Z", "modified": "2021-06-14T06:33:28.938Z"}, {"entity": "publication", "iuid": "638334507f99412a8f18438594fcaacd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/638334507f99412a8f18438594fcaacd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/638334507f99412a8f18438594fcaacd"}}, "title": "Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2", "authors": [{"family": "Hassan", "given": "Sk Sarif", "initials": "SS"}, {"family": "Attrish", "given": "Diksha", "initials": "D"}, {"family": "Ghosh", "given": "Shinjini", "initials": "S"}, {"family": "Choudhury", "given": "Pabitra Pal", "initials": "PP"}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN"}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA"}, {"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Uhal", "given": "Bruce D", "initials": "BD"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Seyran", "given": "Murat", "initials": "M"}, {"family": "Pizzol", "given": "Damiano", "initials": "D"}, {"family": "Adadi", "given": "Parise", "initials": "P"}, {"family": "Soares", "given": "Antonio", "initials": "A"}, {"family": "Abd El-Aziz", "given": "Tarek Mohamed", "initials": "TM"}, {"family": "Kandimalla", "given": "Ramesh", "initials": "R"}, {"family": "Tambuwala", "given": "Murtaza M", "initials": "MM"}, {"family": "Azad", "given": "Gajendra Kumar", "initials": "GK"}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Baetas-da-Cruz", "given": "Wagner", "initials": "W"}, {"family": "Lal", "given": "Amos", "initials": "A"}, {"family": "Pal\u00f9", "given": "Giorgio", "initials": "G"}, {"family": "Takayama", "given": "Kazuo", "initials": "K"}, {"family": "Serrano-Aroca", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "Barh", "given": "Debmalya", "initials": "D"}, {"family": "Brufsky", "given": "Adam M", "initials": "AM"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "International Journal of Biological Macromolecules", "issn": "0141-8130", "volume": "181", "issue": null, "pages": "801-809", "issn-l": null}, "abstract": null, "doi": "10.1016/j.ijbiomac.2021.03.199", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-19T10:37:28.411Z", "modified": "2021-04-19T10:37:28.436Z"}, {"entity": "publication", "iuid": "c80dd926ac8d4140824baeb0ba34e4e5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c80dd926ac8d4140824baeb0ba34e4e5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c80dd926ac8d4140824baeb0ba34e4e5"}}, "title": "Modest effects of dietary supplements during the COVID-19 pandemic: insights from 445 850 users of the COVID-19 Symptom Study app", "authors": [{"family": "Louca", "given": "Panayiotis", "initials": "P", "orcid": "0000-0001-5956-1433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44d3563d8537415488d45a381ccd0604.json"}}, {"family": "Murray", "given": "Benjamin", "initials": "B", "orcid": "0000-0002-8198-8131", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/633d9bf9646d4c07a6611f21e67dc798.json"}}, {"family": "Klaser", "given": "Kerstin", "initials": "K", "orcid": "0000-0002-5230-6939", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6eaf3d777b444dec814026eceb65de8c.json"}}, {"family": "Graham", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-4170-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f5f4e19812a46ed9e873732ec25e28d.json"}}, {"family": "Mazidi", "given": "Mohsen", "initials": "M", "orcid": "0000-0003-3059-229X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d50a209c0b64f3b93703515c57f1334.json"}}, {"family": "Leeming", "given": "Emily R", "initials": "ER", "orcid": "0000-0002-0531-4901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59a9e4a4912f451c861668efdd226c44.json"}}, {"family": "Thompson", "given": "Ellen", "initials": "E", "orcid": "0000-0003-2118-821X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6754739394b24a5c8f5db22905b22c3c.json"}}, {"family": "Bowyer", "given": "Ruth", "initials": "R", "orcid": "0000-0002-6941-8160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eebaf361c184499ca6729aa60cc0af3d.json"}}, {"family": "Drew", "given": "David A", "initials": "DA", "orcid": "0000-0002-8813-0816", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd3a2cffdc104f18b8684cf4f27d68b2.json"}}, {"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Merino", "given": "Jordi", "initials": "J", "orcid": "0000-0001-8312-1438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12ab049914a542b39affcfb4196861d2.json"}}, {"family": "Gomez", "given": "Maria", "initials": "M", "orcid": "0000-0001-6210-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e09e37219c4f42c8a7b3a982da523859.json"}}, {"family": "Mompeo", "given": "Olatz", "initials": "O", "orcid": "0000-0002-1754-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2051c14cd79e43b3b1f168c7c896aa8a.json"}}, {"family": "Costeira", "given": "Ricardo", "initials": "R", "orcid": "0000-0002-8316-5219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f9a3632463540a4930b5f7ac70d0faa.json"}}, {"family": "Sudre", "given": "Carole H", "initials": "CH", "orcid": "0000-0001-5753-428X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c26472813fed4007a8757af771de1802.json"}}, {"family": "Gibson", "given": "Rachel", "initials": "R", "orcid": "0000-0002-5823-6468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/def9e18b28a34704b6d658bc0d82fa14.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74cf1f7094744ee289fa5df041e7cb5b.json"}}, {"family": "Ourselin", "given": "Sebastien", "initials": "S", "orcid": "0000-0002-5694-5340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74c7b9b1633144879042d198c7205656.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-7284-6767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeefbf47fd384d5390109fe1a903bd18.json"}}, {"family": "Berry", "given": "Sarah E", "initials": "SE", "orcid": "0000-0002-5819-5109", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90a2ad26c7694c379586df859629c77d.json"}}, {"family": "Valdes", "given": "Ana M", "initials": "AM", "orcid": "0000-0003-1141-4471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25a57a383f7f42ad82558fa66564fdf9.json"}}, {"family": "Calder", "given": "Philip C", "initials": "PC", "orcid": "0000-0002-6038-710X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0057aacc763d4e448ba964c8c238a32b.json"}}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874802ae65824a90ba50eabdeabb8356.json"}}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "BMJ Nutr Prev Health", "issn": "2516-5542", "volume": "4", "issue": "1", "pages": "149-157", "issn-l": null}, "abstract": "Dietary supplements may ameliorate SARS-CoV-2 infection, although scientific evidence to support such a role is lacking. We investigated whether users of the COVID-19 Symptom Study app who regularly took dietary supplements were less likely to test positive for SARS-CoV-2 infection.\n\nApp-based community survey.\n\n445 850 subscribers of an app that was launched to enable self-reported information related to SARS-CoV-2 infection for use in the general population in the UK (n=372 720), the USA (n=45 757) and Sweden (n=27 373).\n\nSelf-reported regular dietary supplement usage (constant use during previous 3 months) in the first waves of the pandemic up to 31 July 2020.\n\nSARS-CoV-2 infection confirmed by viral RNA reverse transcriptase PCR test or serology test before 31 July 2020.\n\nIn 372 720 UK participants (175 652 supplement users and 197 068 non-users), those taking probiotics, omega-3 fatty acids, multivitamins or vitamin D had a lower risk of SARS-CoV-2 infection by 14% (95% CI (8% to 19%)), 12% (95% CI (8% to 16%)), 13% (95% CI (10% to 16%)) and 9% (95% CI (6% to 12%)), respectively, after adjusting for potential confounders. No effect was observed for those taking vitamin C, zinc or garlic supplements. On stratification by sex, age and body mass index (BMI), the protective associations in individuals taking probiotics, omega-3 fatty acids, multivitamins and vitamin D were observed in females across all ages and BMI groups, but were not seen in men. The same overall pattern of association was observed in both the US and Swedish cohorts.\n\nIn women, we observed a modest but significant association between use of probiotics, omega-3 fatty acid, multivitamin or vitamin D supplements and lower risk of testing positive for SARS-CoV-2. We found no clear benefits for men nor any effect of vitamin C, garlic or zinc. Randomised controlled trials are required to confirm these observational findings before any therapeutic recommendations can be made.", "doi": "10.1136/bmjnph-2021-000250", "pmid": "34308122", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjnph-2021-000250"}, {"db": "pmc", "key": "PMC8061565"}, {"db": "URL", "key": "https://covid.joinzoe.com", "description": "ZOE COVID Study website (providing information on raw data and data visualisations)"}, {"db": "URL", "key": "https://nutrition.bmj.com/content/4/1/149#supplementary-materials", "description": "Supplementary Information (includes information on relevant survey questions, summary statistics and flowcharts about the study)"}], "notes": [], "created": "2021-08-05T06:54:01.869Z", "modified": "2021-08-13T05:42:50.446Z"}, {"entity": "publication", "iuid": "aa000107f0344b9089a9673d588ec8f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aa000107f0344b9089a9673d588ec8f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aa000107f0344b9089a9673d588ec8f8"}}, "title": "Longitudinal variability in mortality predicts COVID-19 deaths.", "authors": [{"family": "Lundberg", "given": "Jon O", "initials": "JO", "orcid": "0000-0002-0174-5210", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78a32d00021a47db8c21c5a4f2419638.json"}}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ee1510080704cf6a2a6972deb94123f.json"}}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Eur J Epidemiol", "issn": "1573-7284", "issn-l": "0393-2990", "volume": "36", "issue": "6", "pages": "599-603"}, "abstract": "Within Europe, death rates due to COVID-19 vary greatly, with some countries being severely hit while others to date are almost unaffected. This has created a heated debate in particular regarding how effective the different measures applied by the governments are in limiting the spread of the disease and ultimately deaths. It would be of considerable interest to pinpoint the factors that determine a country's susceptibility to a pandemic such as COVID-19. Here we present data demonstrating that mortality due to COVID-19 in a given country could have been predicted to some extent even before the pandemic hit Europe, simply by looking at longitudinal variability of death rates in the years preceding the current outbreak. The variability in death rates during the winter influenza seasons of 2015-2019 correlates to excess mortality in 2020 during the COVID-19 outbreak (Spearman's \u03c1 = 0.68, 95 % CI = 0.40-0.84, p < 0.001). In contrast, there was no correlation with age, population density, latitude, GNP, governmental health spending, number of intensive care beds, degree of urbanization, or rates of influenza vaccination. These data suggest an intrinsic susceptibility in certain countries to excess mortality associated with viral respiratory diseases including COVID-19.", "doi": "10.1007/s10654-021-00777-x", "pmid": "34218343", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10654-021-00777-x"}, {"db": "pmc", "key": "PMC8254667"}], "notes": [], "created": "2021-07-05T15:07:36.224Z", "modified": "2021-08-16T14:24:38.154Z"}, {"entity": "publication", "iuid": "90a791f266b04f929d7c174b43847ea9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90a791f266b04f929d7c174b43847ea9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90a791f266b04f929d7c174b43847ea9"}}, "title": "Immunogenicity of the BNT162b2 vaccine in frail or disabled nursing home residents: COVID-A study.", "authors": [{"family": "Salmer\u00f3n R\u00edos", "given": "Sergio", "initials": "S"}, {"family": "Mas Romero", "given": "Marta", "initials": "M"}, {"family": "Cort\u00e9s Zamora", "given": "Elisa Bel\u00e9n", "initials": "EB"}, {"family": "Tabernero Sahuquillo", "given": "Mar\u00eda Teresa", "initials": "MT"}, {"family": "Romero Rizos", "given": "Luis", "initials": "L"}, {"family": "S\u00e1nchez-Jurado", "given": "Pedro Manuel", "initials": "PM"}, {"family": "S\u00e1nchez-Nievas", "given": "Gin\u00e9s", "initials": "G"}, {"family": "Se\u00f1alada", "given": "Jos\u00e9 Joaqu\u00edn Blas", "initials": "JJB"}, {"family": "Garc\u00eda Nogueras", "given": "Inmaculada", "initials": "I"}, {"family": "Estrella Cazalla", "given": "Juan de Dios", "initials": "JdD"}, {"family": "Andr\u00e9s-Pretel", "given": "Fernando", "initials": "F"}, {"family": "Murillo Romero", "given": "Antonio", "initials": "A"}, {"family": "Lauschke", "given": "Volker Martin", "initials": "VM"}, {"family": "Stebbing", "given": "Justin", "initials": "J"}, {"family": "Abizanda", "given": "Pedro", "initials": "P"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "J Am Geriatr Soc", "issn": "0002-8614", "volume": "69", "issue": "6", "issn-l": null, "pages": "1441-1447"}, "abstract": "The safety and immunogenicity of the BNT162b2 coronavirus disease 2019 (COVID-19) vaccine in older adults with different frailty and disability profiles have not been well determined. Our objective was to analyze immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in older adults across frailty and disability profiles.\r\n\r\nMulticenter longitudinal cohort study.\r\n\r\nA total of 134 residents aged \u226565 years with different frailty and disability profiles in five long-term care facilities (LTCFs) in Albacete, Spain.\r\n\r\nResidents were administered two vaccine doses as per the label, and antibody levels were determined 21.9 days (SD 9.3) after both the first and second dose. Functional variables were assessed using activities of daily living (Barthel Index), and frailty status was determined with the FRAIL instrument. Cognitive status and comorbidity were also evaluated.\r\n\r\nMean age was 82.9 years (range 65-99), and 71.6% were female. The mean antibody titers in residents with and without previous COVID-19 infection were 49,878 AU/ml and 15,274 AU/ml, respectively (mean difference 34,604; 95% confidence interval [CI]: 27,699-41,509). No severe adverse reactions were observed, after either vaccine dose. Those with prevaccination COVID-19 had an increased antibody level after the vaccine (B = 31,337; 95% CI: 22,725-39,950; p < 0.001). Frailty, disability, older age, sex, cognitive impairment, or comorbidities were not associated with different antibody titers.\r\n\r\nThe BNT162b2 mRNA COVID-19 vaccine in older adults is safe and produces immunogenicity, independently of the frailty and disability profiles. Older adults in LTCFs should receive a COVID-19 vaccine.", "doi": "10.1111/jgs.17153", "pmid": "33768521", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8250586"}], "notes": [], "created": "2021-03-29T09:26:15.643Z", "modified": "2021-08-23T14:39:35.931Z"}, {"entity": "publication", "iuid": "885b12d94aef4f74a878db2b333fbae4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/885b12d94aef4f74a878db2b333fbae4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/885b12d94aef4f74a878db2b333fbae4"}}, "title": "Guest attendance data from 34 Swedish pre-schools and primary schools.", "authors": [{"family": "Eriksson", "given": "Mattias", "initials": "M"}, {"family": "Malefors", "given": "Christopher", "initials": "C"}, {"family": "Secondi", "given": "Luca", "initials": "L"}, {"family": "Marchetti", "given": "Stefano", "initials": "S"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Data Brief", "issn": "2352-3409", "issn-l": null, "volume": "36", "issue": null, "pages": "107138"}, "abstract": "This data article describes 34 datasets, compiled into one table, describing guest attendance at lunch meal servings in Swedish public schools and preschools. Fifteen of the schools and all 16 of the preschools covered belong to one municipality, while the remaining three schools belong to two other municipalities, all located in central Sweden. Data on number of plates was used as a proxy of the number of guests eating lunch. Number of used plates was recorded from late August 2010 to early June 2020, i.e. covering the period both before and during the initial phase of the Covid-19 pandemic, so that making possible to evaluate changes in guest attendance during the pandemic. Since these were real data, all data elements pertaining to exact canteens or staff identity have been removed. There is a scarcity of real business data for scientific and educational purposes, so these datasets can play an important role in research and education within catering management, consumption pattern analysis, machine learning, data mining and other fields.", "doi": "10.1016/j.dib.2021.107138", "pmid": "34095385", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S2352-3409(21)00422-4"}, {"db": "pmc", "key": "PMC8165408"}], "notes": [], "created": "2021-06-08T08:56:05.493Z", "modified": "2022-11-22T05:46:23.879Z"}, {"entity": "publication", "iuid": "2ebb0a439bad48b093252fcb2a666c35", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ebb0a439bad48b093252fcb2a666c35.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ebb0a439bad48b093252fcb2a666c35"}}, "title": "Extracellular Vesicle Capture by AnTibody of CHoice and Enzymatic Release (EV-CATCHER): A customizable purification assay designed for small-RNA biomarker identification and evaluation of circulating small-EVs.", "authors": [{"family": "Mitchell", "given": "Megan I", "initials": "MI", "orcid": "0000-0002-1202-155X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a39353b6a1040bda4fc6ec41ce992cf.json"}}, {"family": "Ben-Dov", "given": "Iddo Z", "initials": "IZ"}, {"family": "Liu", "given": "Christina", "initials": "C"}, {"family": "Ye", "given": "Kenny", "initials": "K"}, {"family": "Chow", "given": "Kar", "initials": "K"}, {"family": "Kramer", "given": "Yael", "initials": "Y"}, {"family": "Gangadharan", "given": "Anju", "initials": "A"}, {"family": "Park", "given": "Steven", "initials": "S"}, {"family": "Fitzgerald", "given": "Sean", "initials": "S"}, {"family": "Ramnauth", "given": "Andrew", "initials": "A"}, {"family": "Perlin", "given": "David S", "initials": "DS"}, {"family": "Donato", "given": "Michele", "initials": "M"}, {"family": "Bhoy", "given": "Emily", "initials": "E"}, {"family": "Manouchehri Doulabi", "given": "Ehsan", "initials": "E"}, {"family": "Poulos", "given": "Michael", "initials": "M"}, {"family": "Kamali-Moghaddam", "given": "Masood", "initials": "M"}, {"family": "Loudig", "given": "Olivier", "initials": "O"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "J Extracell Vesicles", "issn": "2001-3078", "issn-l": null, "volume": "10", "issue": "8", "pages": "e12110"}, "abstract": "Circulating nucleic acids, encapsulated within small extracellular vesicles (EVs), provide a remote cellular snapshot of biomarkers derived from diseased tissues, however selective isolation is critical. Current laboratory-based purification techniques rely on the physical properties of small-EVs rather than their inherited cellular fingerprints. We established a highly-selective purification assay, termed EV-CATCHER, initially designed for high-throughput analysis of low-abundance small-RNA cargos by next-generation sequencing. We demonstrated its selectivity by specifically isolating and sequencing small-RNAs from mouse small-EVs spiked into human plasma. Western blotting, nanoparticle tracking, and transmission electron microscopy were used to validate and quantify the capture and release of intact small-EVs. As proof-of-principle for sensitive detection of circulating miRNAs, we compared small-RNA sequencing data from a subset of small-EVs serum-purified with EV-CATCHER to data from whole serum, using samples from a small cohort of recently hospitalized Covid-19 patients. We identified and validated, only in small-EVs, hsa-miR-146a and hsa-miR-126-3p to be significantly downregulated with disease severity. Separately, using convalescent sera from recovered Covid-19 patients with high anti-spike IgG titers, we confirmed the neutralizing properties, against SARS-CoV-2 in vitro, of a subset of small-EVs serum-purified by EV-CATCHER, as initially observed with ultracentrifuged small-EVs. Altogether our data highlight the sensitivity and versatility of EV-CATCHER.", "doi": "10.1002/jev2.12110", "pmid": "34122779", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8173589"}, {"db": "pii", "key": "JEV212110"}], "notes": [], "created": "2021-06-17T07:28:31.678Z", "modified": "2023-06-19T15:06:28.471Z"}, {"entity": "publication", "iuid": "3fea64a67cbe40219cc97c9ee830c67a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3fea64a67cbe40219cc97c9ee830c67a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3fea64a67cbe40219cc97c9ee830c67a"}}, "title": "Excess Mortality After COVID-19 in Swedish Long-Term Care Facilities", "authors": [{"family": "Ballin", "given": "Marcel", "initials": "M"}, {"family": "Bergman", "given": "Jonathan", "initials": "J"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Nordstr\u00f6m", "given": "Peter", "initials": "P"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "Journal of the American Medical Directors Association", "issn": "1525-8610", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/j.jamda.2021.06.010", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:08:23.850Z", "modified": "2021-07-14T09:13:47.733Z"}, {"entity": "publication", "iuid": "6e3d5779e96c4475b28d9954590d053a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e3d5779e96c4475b28d9954590d053a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e3d5779e96c4475b28d9954590d053a"}}, "title": "Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and territories in the Invasive Respiratory Infection Surveillance Initiative: a prospective analysis of surveillance data", "authors": [{"family": "Brueggemann", "given": "Angela B", "initials": "AB"}, {"family": "Jansen van Rensburg", "given": "Melissa J", "initials": "MJ"}, {"family": "Shaw", "given": "David", "initials": "D"}, {"family": "McCarthy", "given": "Noel D", "initials": "ND"}, {"family": "Jolley", "given": "Keith A", "initials": "KA"}, {"family": "Maiden", "given": "Martin C J", "initials": "MCJ"}, {"family": "van der Linden", "given": "Mark P G", "initials": "MPG"}, {"family": "Amin-Chowdhury", "given": "Zahin", "initials": "Z"}, {"family": "Bennett", "given": "D\u00e9sir\u00e9e E", "initials": "DE"}, {"family": "Borrow", "given": "Ray", "initials": "R"}, {"family": "Brandileone", "given": "Maria Cristina C", "initials": "MCC"}, {"family": "Broughton", "given": "Karen", "initials": "K"}, {"family": "Campbell", "given": "Ruth", "initials": "R"}, {"family": "Cao", "given": "Bin", "initials": "B"}, {"family": "Casanova", "given": "Carlo", "initials": "C"}, {"family": "Choi", "given": "Eun Hwa", "initials": "EH"}, {"family": "Chu", "given": "Yiu Wai", "initials": "YW"}, {"family": "Clark", "given": "Stephen A", "initials": "SA"}, {"family": "Claus", "given": "Heike", "initials": "H"}, {"family": "Coelho", "given": "Juliana", "initials": "J"}, {"family": "Corcoran", "given": "Mary", "initials": "M"}, {"family": "Cottrell", "given": "Simon", "initials": "S"}, {"family": "Cunney", "given": "Robert J", "initials": "RJ"}, {"family": "Dalby", "given": "Tine", "initials": "T"}, {"family": "Davies", "given": "Heather", "initials": "H"}, {"family": "de Gouveia", "given": "Linda", "initials": "L"}, {"family": "Deghmane", "given": "Ala Eddine", "initials": "AE"}, {"family": "Demczuk", "given": "Walter", "initials": "W"}, {"family": "Desmet", "given": "Stefanie", "initials": "S"}, {"family": "Drew", "given": "Richard J", "initials": "RJ"}, {"family": "du Plessis", "given": "Mignon", "initials": "M"}, {"family": "Erlendsdottir", "given": "Helga", "initials": "H"}, {"family": "Fry", "given": "Norman K", "initials": "NK"}, {"family": "Fuursted", "given": "Kurt", "initials": "K"}, {"family": "Gray", "given": "Steve J", "initials": "SJ"}, {"family": "Henriques-Normark", "given": "Birgitta", "initials": "B"}, {"family": "Hale", "given": "Thomas", "initials": "T"}, {"family": "Hilty", "given": "Markus", "initials": "M"}, {"family": "Hoffmann", "given": "Steen", "initials": "S"}, {"family": "Humphreys", "given": "Hilary", "initials": "H"}, {"family": "Ip", "given": "Margaret", "initials": "M"}, {"family": "Jacobsson", "given": "Susanne", "initials": "S"}, {"family": "Johnston", "given": "Jillian", "initials": "J"}, {"family": "Kozakova", "given": "Jana", "initials": "J"}, {"family": "Kristinsson", "given": "Karl G", "initials": "KG"}, {"family": "Krizova", "given": "Pavla", "initials": "P"}, {"family": "Kuch", "given": "Alicja", "initials": "A"}, {"family": "Ladhani", "given": "Shamez N", "initials": "SN"}, {"family": "L\u00e2m", "given": "Thi\u00ean Tr\u00ed", "initials": "TT"}, {"family": "Lebedova", "given": "Vera", "initials": "V"}, {"family": "Lindholm", "given": "Laura", "initials": "L"}, {"family": "Litt", "given": "David J", "initials": "DJ"}, {"family": "Martin", "given": "Irene", "initials": "I"}, {"family": "Martiny", "given": "Delphine", "initials": "D"}, {"family": "Mattheus", "given": "Wesley", "initials": "W"}, {"family": "McElligott", "given": "Martha", "initials": "M"}, {"family": "Meehan", "given": "Mary", "initials": "M"}, {"family": "Meiring", "given": "Susan", "initials": "S"}, {"family": "M\u00f6lling", "given": "Paula", "initials": "P"}, {"family": "Morfeldt", "given": "Eva", "initials": "E"}, {"family": "Morgan", "given": "Julie", "initials": "J"}, {"family": "Mulhall", "given": "Robert M", "initials": "RM"}, {"family": "Mu\u00f1oz-Almagro", "given": "Carmen", "initials": "C"}, {"family": "Murdoch", "given": "David R", "initials": "DR"}, {"family": "Murphy", "given": "Joy", "initials": "J"}, {"family": "Musilek", "given": "Martin", "initials": "M"}, {"family": "Mzabi", "given": "Alexandre", "initials": "A"}, {"family": "Perez-Arg\u00fcello", "given": "Amaresh", "initials": "A"}, {"family": "Perrin", "given": "Monique", "initials": "M"}, {"family": "Perry", "given": "Malorie", "initials": "M"}, {"family": "Redin", "given": "Alba", "initials": "A"}, {"family": "Roberts", "given": "Richard", "initials": "R"}, {"family": "Roberts", "given": "Maria", "initials": "M"}, {"family": "Rokney", "given": "Assaf", "initials": "A"}, {"family": "Ron", "given": "Merav", "initials": "M"}, {"family": "Scott", "given": "Kevin J", "initials": "KJ"}, {"family": "Sheppard", "given": "Carmen L", "initials": "CL"}, {"family": "Siira", "given": "Lotta", "initials": "L"}, {"family": "Skoczy\u0144ska", "given": "Anna", "initials": "A"}, {"family": "Sloan", "given": "Monica", "initials": "M"}, {"family": "Slotved", "given": "Hans Christian", "initials": "HC"}, {"family": "Smith", "given": "Andrew J", "initials": "AJ"}, {"family": "Song", "given": "Joon Young", "initials": "JY"}, {"family": "Taha", "given": "Muhamed Kheir", "initials": "MK"}, {"family": "Toropainen", "given": "Maija", "initials": "M"}, {"family": "Tsang", "given": "Dominic", "initials": "D"}, {"family": "Vainio", "given": "Anni", "initials": "A"}, {"family": "van Sorge", "given": "Nina M", "initials": "NM"}, {"family": "Varon", "given": "Emmanuelle", "initials": "E"}, {"family": "Vlach", "given": "Jiri", "initials": "J"}, {"family": "Vogel", "given": "Ulrich", "initials": "U"}, {"family": "Vohrnova", "given": "Sandra", "initials": "S"}, {"family": "von Gottberg", "given": "Anne", "initials": "A"}, {"family": "Zanella", "given": "Rosemeire C", "initials": "RC"}, {"family": "Zhou", "given": "Fei", "initials": "F"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "The Lancet Digital Health", "issn": "2589-7500", "issn-l": null, "volume": "3", "issue": "6", "pages": "e360-e370"}, "abstract": "Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis, which are typically transmitted via respiratory droplets, are leading causes of invasive diseases, including bacteraemic pneumonia and meningitis, and of secondary infections subsequent to post-viral respiratory disease. The aim of this study was to investigate the incidence of invasive disease due to these pathogens during the early months of the COVID-19 pandemic.\r\n\r\nIn this prospective analysis of surveillance data, laboratories in 26 countries and territories across six continents submitted data on cases of invasive disease due to S pneumoniae, H influenzae, and N meningitidis from Jan 1, 2018, to May, 31, 2020, as part of the Invasive Respiratory Infection Surveillance (IRIS) Initiative. Numbers of weekly cases in 2020 were compared with corresponding data for 2018 and 2019. Data for invasive disease due to Streptococcus agalactiae, a non-respiratory pathogen, were collected from nine laboratories for comparison. The stringency of COVID-19 containment measures was quantified using the Oxford COVID-19 Government Response Tracker. Changes in population movements were assessed using Google COVID-19 Community Mobility Reports. Interrupted time-series modelling quantified changes in the incidence of invasive disease due to S pneumoniae, H influenzae, and N meningitidis in 2020 relative to when containment measures were imposed.\r\n\r\n27 laboratories from 26 countries and territories submitted data to the IRIS Initiative for S pneumoniae (62 837 total cases), 24 laboratories from 24 countries submitted data for H influenzae (7796 total cases), and 21 laboratories from 21 countries submitted data for N meningitidis (5877 total cases). All countries and territories had experienced a significant and sustained reduction in invasive diseases due to S pneumoniae, H influenzae, and N meningitidis in early 2020 (Jan 1 to May 31, 2020), coinciding with the introduction of COVID-19 containment measures in each country. By contrast, no significant changes in the incidence of invasive S agalactiae infections were observed. Similar trends were observed across most countries and territories despite differing stringency in COVID-19 control policies. The incidence of reported S pneumoniae infections decreased by 68% at 4 weeks (incidence rate ratio 0\u00b732 [95% CI 0\u00b727-0\u00b737]) and 82% at 8 weeks (0\u00b718 [0\u00b714-0\u00b723]) following the week in which significant changes in population movements were recorded.\r\n\r\nThe introduction of COVID-19 containment policies and public information campaigns likely reduced transmission of S pneumoniae, H influenzae, and N meningitidis, leading to a significant reduction in life-threatening invasive diseases in many countries worldwide.\r\n\r\nWellcome Trust (UK), Robert Koch Institute (Germany), Federal Ministry of Health (Germany), Pfizer, Merck, Health Protection Surveillance Centre (Ireland), SpID-Net project (Ireland), European Centre for Disease Prevention and Control (European Union), Horizon 2020 (European Commission), Ministry of Health (Poland), National Programme of Antibiotic Protection (Poland), Ministry of Science and Higher Education (Poland), Agencia de Salut P\u00fablica de Catalunya (Spain), Sant Joan de Deu Foundation (Spain), Knut and Alice Wallenberg Foundation (Sweden), Swedish Research Council (Sweden), Region Stockholm (Sweden), Federal Office of Public Health of Switzerland (Switzerland), and French Public Health Agency (France).", "doi": "10.1016/s2589-7500(21)00077-7", "pmid": "34045002", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2589-7500(21)00077-7"}, {"db": "URL", "key": "https://github.com/brueggemann-lab/iris-ldh-2020/tree/main/code", "description": "Data processing, visualisation, analysis code"}], "notes": [], "created": "2021-05-29T15:25:23.212Z", "modified": "2021-12-22T12:47:24.255Z"}, {"entity": "publication", "iuid": "6a107e18fba94c87bfcf92e94c907307", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a107e18fba94c87bfcf92e94c907307.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a107e18fba94c87bfcf92e94c907307"}}, "title": "Cardiovascular-related deaths at the beginning of the COVID-19 outbreak: a prospective analysis based on the UK Biobank", "authors": [{"family": "Wang", "given": "Junren", "initials": "J"}, {"family": "Zhu", "given": "Jianwei", "initials": "J"}, {"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Sun", "given": "Yajing", "initials": "Y"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "Qu", "given": "Yuanyuan", "initials": "Y"}, {"family": "Valdimarsdottir", "given": "Unnur", "initials": "U"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "6", "pages": "e046931"}, "abstract": null, "doi": "10.1136/bmjopen-2020-046931", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-08T08:44:53.007Z", "modified": "2021-06-08T08:45:06.122Z"}, {"entity": "publication", "iuid": "882b84f8d9014804bb645ecafcfd3ced", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/882b84f8d9014804bb645ecafcfd3ced.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/882b84f8d9014804bb645ecafcfd3ced"}}, "title": "COVID-19 in immunocompromised populations: implications for prognosis and repurposing of immunotherapies.", "authors": [{"family": "Goldman", "given": "Jason D", "initials": "JD", "orcid": "0000-0002-3825-6832", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87e08520608949ac9fa338a38550098b.json"}}, {"family": "Robinson", "given": "Philip C", "initials": "PC", "orcid": "0000-0002-3156-3418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/950b622d31724172817ccde09902d215.json"}}, {"family": "Uldrick", "given": "Thomas S", "initials": "TS", "orcid": "0000-0001-6959-0924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69d5a4f766394718943dea6300513856.json"}}, {"family": "Ljungman", "given": "Per", "initials": "P", "orcid": "0000-0002-8281-3245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4546eb504184683ab712eee858ea9cb.json"}}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "J Immunother Cancer", "issn": "2051-1426", "volume": "9", "issue": "6", "issn-l": null}, "abstract": "SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. COVID-19 has highly variable disease severity and a bimodal course characterized by acute respiratory viral infection followed by hyperinflammation in a subset of patients with severe disease. This immune dysregulation is characterized by lymphocytopenia, elevated levels of plasma cytokines and proliferative and exhausted T cells, among other dysfunctional cell types. Immunocompromised persons often fare worse in the context of acute respiratory infections, but preliminary data suggest this may not hold true for COVID-19. In this review, we explore the effect of SARS-CoV-2 infection on mortality in four populations with distinct forms of immunocompromise: (1) persons with hematological malignancies (HM) and hematopoietic stem cell transplant (HCT) recipients; (2) solid organ transplant recipients (SOTRs); (3) persons with rheumatological diseases; and (4) persons living with HIV (PLWH). For each population, key immunological defects are described and how these relate to the immune dysregulation in COVID-19. Next, outcomes including mortality after SARS-CoV-2 infection are described for each population, giving comparisons to the general population of age-matched and comorbidity-matched controls. In these four populations, iatrogenic or disease-related immunosuppression is not clearly associated with poor prognosis in HM, HCT, SOTR, rheumatological diseases, or HIV. However, certain individual immunosuppressants or disease states may be associated with harmful or beneficial effects, including harm from severe CD4 lymphocytopenia in PLWH and possible benefit to the calcineurin inhibitor ciclosporin in SOTRs, or tumor necrosis factor-\u03b1 inhibitors in persons with rheumatic diseases. Lastly, insights gained from clinical and translational studies are explored as to the relevance for repurposing of immunosuppressive host-directed therapies for the treatment of hyperinflammation in COVID-19 in the general population.", "doi": "10.1136/jitc-2021-002630", "pmid": "34117116", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jitc-2021-002630"}], "notes": [], "created": "2021-06-14T06:33:51.825Z", "modified": "2021-06-14T06:33:53.045Z"}, {"entity": "publication", "iuid": "020205cca7b44ead9df18e321fb13dd1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/020205cca7b44ead9df18e321fb13dd1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/020205cca7b44ead9df18e321fb13dd1"}}, "title": "Autoimmune Encephalitis Presenting With Malignant Catatonia in a 40-Year-Old Male Patient With COVID-19.", "authors": [{"family": "Mulder", "given": "Jan", "initials": "J"}, {"family": "Feresiadou", "given": "Amalia", "initials": "A"}, {"family": "F\u00e4llmar", "given": "David", "initials": "D"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "Rasmusson", "given": "Annica", "initials": "A"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Cunningham", "given": "Janet L", "initials": "JL"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Am J Psychiatry", "issn": "1535-7228", "volume": "178", "issue": "6", "pages": "485-489", "issn-l": null}, "abstract": null, "doi": "10.1176/appi.ajp.2020.20081236", "pmid": "34154381", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:23:09.280Z", "modified": "2021-06-28T18:23:09.306Z"}, {"entity": "publication", "iuid": "228ce5c33a6e43868dc6d99a1b519861", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/228ce5c33a6e43868dc6d99a1b519861.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/228ce5c33a6e43868dc6d99a1b519861"}}, "title": "Author Correction: Attributes and predictors of long COVID.", "authors": [{"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Murray", "given": "Benjamin", "initials": "B", "orcid": "0000-0002-2413-923X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebec738df0224bf4874fd6c08fd23fae.json"}}, {"family": "Varsavsky", "given": "Thomas", "initials": "T"}, {"family": "Graham", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-4170-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f5f4e19812a46ed9e873732ec25e28d.json"}}, {"family": "Penfold", "given": "Rose S", "initials": "RS"}, {"family": "Bowyer", "given": "Ruth C", "initials": "RC", "orcid": "0000-0002-6941-8160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eebaf361c184499ca6729aa60cc0af3d.json"}}, {"family": "Pujol", "given": "Joan Capdevila", "initials": "JC", "orcid": "0000-0003-1658-1076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60965a027a4b4d048728748f09c98594.json"}}, {"family": "Klaser", "given": "Kerstin", "initials": "K"}, {"family": "Antonelli", "given": "Michela", "initials": "M"}, {"family": "Canas", "given": "Liane S", "initials": "LS"}, {"family": "Molteni", "given": "Erika", "initials": "E", "orcid": "0000-0001-7773-8140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9aed1fbe444b48d4bfacb12050953c8e.json"}}, {"family": "Modat", "given": "Marc", "initials": "M"}, {"family": "Jorge Cardoso", "given": "M", "initials": "M", "orcid": "0000-0003-1284-2558", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0ed3abec67644e186650e1d1dcbbe0b.json"}}, {"family": "May", "given": "Anna", "initials": "A"}, {"family": "Ganesh", "given": "Sajaysurya", "initials": "S", "orcid": "0000-0002-3720-4176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6dbf91180806442082ce6732c1b75923.json"}}, {"family": "Davies", "given": "Richard", "initials": "R", "orcid": "0000-0003-2050-3994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b82cc92615f462d9af0153a6fb94fde.json"}}, {"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Drew", "given": "David A", "initials": "DA", "orcid": "0000-0002-8813-0816", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd3a2cffdc104f18b8684cf4f27d68b2.json"}}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Merino", "given": "Jordi", "initials": "J", "orcid": "0000-0001-8312-1438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12ab049914a542b39affcfb4196861d2.json"}}, {"family": "Tsereteli", "given": "Neli", "initials": "N"}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f34c0d3602439abe6096293c7c732d.json"}}, {"family": "Gomez", "given": "Maria F", "initials": "MF", "orcid": "0000-0001-6210-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e09e37219c4f42c8a7b3a982da523859.json"}}, {"family": "Duncan", "given": "Emma L", "initials": "EL"}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874802ae65824a90ba50eabdeabb8356.json"}}, {"family": "Williams", "given": "Frances M K", "initials": "FMK", "orcid": "0000-0002-2998-2744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87a6db988c2e421f81fce7773436aefa.json"}}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74cf1f7094744ee289fa5df041e7cb5b.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-7284-6767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeefbf47fd384d5390109fe1a903bd18.json"}}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Ourselin", "given": "Sebastien", "initials": "S", "orcid": "0000-0002-5694-5340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74c7b9b1633144879042d198c7205656.json"}}, {"family": "Spector", "given": "Tim", "initials": "T", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}], "type": "published erratum", "published": "2021-06-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956", "volume": "27", "issue": "6", "pages": "1116"}, "abstract": null, "doi": "10.1038/s41591-021-01361-2", "pmid": "34045738", "labels": {"Type: Other": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-021-01361-2"}], "notes": [], "created": "2021-05-29T15:23:39.445Z", "modified": "2023-06-19T15:28:16.046Z"}, {"entity": "publication", "iuid": "95a6e8fb6e3047ffad0f3a0583b05a01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95a6e8fb6e3047ffad0f3a0583b05a01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95a6e8fb6e3047ffad0f3a0583b05a01"}}, "title": "Association Between Collagenous and Lymphocytic Colitis and Risk of Severe Coronavirus Disease 2019", "authors": [{"family": "Khalili", "given": "Hamed", "initials": "H", "orcid": "0000-0002-7956-6941", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e248e3e76594014af041c8e62cfcfc6.json"}}, {"family": "Zheng", "given": "Tenghao", "initials": "T"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Larsson", "given": "Emma", "initials": "E"}, {"family": "Munch", "given": "Andreas", "initials": "A"}, {"family": "Sjoberg", "given": "Klas", "initials": "K"}, {"family": "Almer", "given": "Sven", "initials": "S"}, {"family": "Vigren", "given": "Lina", "initials": "L"}, {"family": "Janczewska", "given": "Izabella", "initials": "I"}, {"family": "Ohlsson", "given": "Bodil", "initials": "B"}, {"family": "Bresso", "given": "Francesca", "initials": "F"}, {"family": "Mellander", "given": "Maire Rose", "initials": "MR"}, {"family": "Ol\u00e9n", "given": "Ola", "initials": "O"}, {"family": "Roelstraete", "given": "Bjorn", "initials": "B"}, {"family": "Franke", "given": "Andre", "initials": "A"}, {"family": "Simon", "given": "Tracey G", "initials": "TG"}, {"family": "D'Amato", "given": "Mauro", "initials": "M"}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "Gastroenterology", "issn": "1528-0012", "issn-l": null, "volume": "160", "issue": "7", "pages": "2585-2587.e3"}, "abstract": null, "doi": "10.1053/j.gastro.2021.02.029", "pmid": "33610527", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0016-5085(21)00417-0"}], "notes": [], "created": "2021-02-22T11:50:13.123Z", "modified": "2021-06-18T12:17:26.842Z"}, {"entity": "publication", "iuid": "e9633a955a014394a5c1b34238b492cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e9633a955a014394a5c1b34238b492cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e9633a955a014394a5c1b34238b492cf"}}, "title": "Are in-person scientific conferences dead or alive?", "authors": [{"family": "Dua", "given": "Nick", "initials": "N"}, {"family": "Fyrenius", "given": "Mattias", "initials": "M"}, {"family": "Johnson", "given": "Deborah L", "initials": "DL"}, {"family": "Moos", "given": "Walter H", "initials": "WH", "orcid": "0000-0001-7244-811X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc7341bafa42423e8d16afd76b97ed64.json"}}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "FASEB Bioadv", "issn": "2573-9832", "volume": "3", "issue": "6", "pages": "420-427", "issn-l": null}, "abstract": "Given the disruption caused by the COVID-19 pandemic, life as we knew it has been turned upside down, but the need for science to go on has never been stronger. In the realm of scientific conferences, with the requirement for social distancing, the importance of wearing face coverings, and travel restrictions, only virtual meetings have been possible during the pandemic. But many are asking: What is the new post-pandemic normal likely to be? Do we still want to have in-person meetings when the restrictions are eased? Assuming we do, when will they be possible again, and under what conditions? Regardless of what the benefits of virtual symposia might be, are they here to stay? These questions, and many more that are being asked around the world today, are the subject of this perspective. Herein, we attempt to provide useful context and insight into where scientific meetings have been, where they are today, where they are going, and how they will get there. Our conclusion is that the pandemic has created an accelerated opportunity to make the world of future scientific conferences better in a \"both/and\" collaborative in-person/virtual scenario, not the more limited \"pick one\" choice.", "doi": "10.1096/fba.2020-00139", "pmid": "34124597", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "FBA21205"}, {"db": "pmc", "key": "PMC8171307"}], "notes": [], "created": "2021-06-17T07:40:58.715Z", "modified": "2021-06-17T07:40:58.766Z"}, {"entity": "publication", "iuid": "0cc8de28a8744ab880da9073a0059bab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0cc8de28a8744ab880da9073a0059bab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0cc8de28a8744ab880da9073a0059bab"}}, "title": "Antimicrobial resistance research in a post-pandemic world: Insights on antimicrobial resistance research in the COVID-19 pandemic", "authors": [{"family": "Rodr\u00edguez-Ba\u00f1o", "given": "Jes\u00fas", "initials": "J"}, {"family": "Rossolini", "given": "Gian Maria", "initials": "GM"}, {"family": "Schultsz", "given": "Constance", "initials": "C"}, {"family": "Tacconelli", "given": "Evelina", "initials": "E"}, {"family": "Murthy", "given": "Srinivas", "initials": "S"}, {"family": "Ohmagari", "given": "Norio", "initials": "N"}, {"family": "Holmes", "given": "Alison", "initials": "A"}, {"family": "Bachmann", "given": "Till", "initials": "T"}, {"family": "Goossens", "given": "Herman", "initials": "H"}, {"family": "Canton", "given": "Rafael", "initials": "R"}, {"family": "Roberts", "given": "Adam P", "initials": "AP"}, {"family": "Henriques-Normark", "given": "Birgitta", "initials": "B"}, {"family": "Clancy", "given": "Cornelius J", "initials": "CJ"}, {"family": "Huttner", "given": "Benedikt", "initials": "B"}, {"family": "Fagerstedt", "given": "Patriq", "initials": "P"}, {"family": "Lahiri", "given": "Shawon", "initials": "S"}, {"family": "Kaushic", "given": "Charu", "initials": "C"}, {"family": "Hoffman", "given": "Steven J", "initials": "SJ"}, {"family": "Warren", "given": "Margo", "initials": "M"}, {"family": "Zoubiane", "given": "Ghada", "initials": "G"}, {"family": "Essack", "given": "Sabiha", "initials": "S"}, {"family": "Laxminarayan", "given": "Ramanan", "initials": "R"}, {"family": "Plant", "given": "Laura", "initials": "L"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "Journal of Global Antimicrobial Resistance", "issn": "2213-7165", "volume": "25", "issue": null, "pages": "5-7", "issn-l": null}, "abstract": "Antimicrobial resistance must be recognised as a global societal priority - even in the face of the worldwide challenge of the COVID-19 pandemic. COVID-19 has illustrated the vulnerability of our healthcare systems in co-managing multiple infectious disease threats as resources for monitoring and detecting, and conducting research on antimicrobial resistance have been compromised during the pandemic. The increased awareness of the importance of infectious diseases, clinical microbiology and infection control and lessons learnt during the COVID-19 pandemic should be exploited to ensure that emergence of future infectious disease threats, including those related to AMR, are minimised. Harnessing the public understanding of the relevance of infectious diseases towards the long-term pandemic of AMR could have major implications for promoting good practices about the control of AMR transmission.", "doi": "10.1016/j.jgar.2021.02.013", "pmid": "33662647", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-7165(21)00045-X"}, {"db": "pmc", "key": "PMC7919515"}], "notes": [], "created": "2021-03-06T10:20:21.390Z", "modified": "2021-12-22T12:47:00.874Z"}, {"entity": "publication", "iuid": "9b8650bb534049239347a549570038aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b8650bb534049239347a549570038aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b8650bb534049239347a549570038aa"}}, "title": "A unique view of SARS-COV-2 through the lens of ORF8 protein", "authors": [{"family": "Hassan", "given": "Sk Sarif", "initials": "SS"}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA"}, {"family": "Panda", "given": "Pritam Kumar", "initials": "PK"}, {"family": "Ghosh", "given": "Shinjini", "initials": "S"}, {"family": "Attrish", "given": "Diksha", "initials": "D"}, {"family": "Choudhury", "given": "Pabitra Pal", "initials": "PP"}, {"family": "Seyran", "given": "Murat", "initials": "M"}, {"family": "Pizzol", "given": "Damiano", "initials": "D"}, {"family": "Adadi", "given": "Parise", "initials": "P"}, {"family": "Abd El-Aziz", "given": "Tarek Mohamed", "initials": "TM"}, {"family": "Soares", "given": "Antonio", "initials": "A"}, {"family": "Kandimalla", "given": "Ramesh", "initials": "R"}, {"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Lal", "given": "Amos", "initials": "A"}, {"family": "Azad", "given": "Gajendra Kumar", "initials": "GK"}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN"}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Baetas-da-Cruz", "given": "Wagner", "initials": "W"}, {"family": "Uhal", "given": "Bruce D", "initials": "BD"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Chauhan", "given": "Gaurav", "initials": "G"}, {"family": "Barh", "given": "Debmalya", "initials": "D"}, {"family": "Redwan", "given": "Elrashdy M", "initials": "EM"}, {"family": "Dayhoff", "given": "Guy W", "initials": "GW"}, {"family": "Bazan", "given": "Nicolas G", "initials": "NG"}, {"family": "Serrano-Aroca", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "El-Demerdash", "given": "Amr", "initials": "A"}, {"family": "Mishra", "given": "Yogendra K", "initials": "YK"}, {"family": "Palu", "given": "Giorgio", "initials": "G"}, {"family": "Takayama", "given": "Kazuo", "initials": "K"}, {"family": "Brufsky", "given": "Adam M", "initials": "AM"}, {"family": "Tambuwala", "given": "Murtaza M", "initials": "MM"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "Computers in Biology and Medicine", "issn": "0010-4825", "issn-l": null, "volume": "133", "issue": null, "pages": "104380"}, "abstract": null, "doi": "10.1016/j.compbiomed.2021.104380", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-20T17:50:03.288Z", "modified": "2021-06-30T05:18:19.633Z"}, {"entity": "publication", "iuid": "76c6675ecd144263b48025aceb887ab0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76c6675ecd144263b48025aceb887ab0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76c6675ecd144263b48025aceb887ab0"}}, "title": "A collection of the novel coronavirus (COVID-19) detection assays, issues, and challenges.", "authors": [{"family": "Rezvani Ghomi", "given": "Erfan", "initials": "E"}, {"family": "Khosravi", "given": "Fatemeh", "initials": "F"}, {"family": "Mohseni-M", "given": "Ali", "initials": "A"}, {"family": "Nourbakhsh", "given": "Nooshin", "initials": "N"}, {"family": "Haji Mohammad Hoseini", "given": "Mahsa", "initials": "M"}, {"family": "Singh", "given": "Sunpreet", "initials": "S"}, {"family": "Hedenqvist", "given": "Mikael S", "initials": "MS"}, {"family": "Ramakrishna", "given": "Seeram", "initials": "S"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "issn-l": null, "volume": "7", "issue": "6", "pages": "e07247"}, "abstract": "The global pandemic of COVID-19 has rapidly increased the number of infected cases as well as asymptomatic individuals in many, if not all the societies around the world. This issue increases the demand for accurate and rapid detection of SARS-CoV-2. While accurate and rapid detection is critical for diagnosing SARS-CoV-2, the appropriate course of treatment must be chosen to help patients and prevent its further spread. Testing platform accuracy with high sensitivity and specificity for SARS-CoV-2 is equally important for clinical, regional, and global arenas to mitigate secondary transmission rounds. The objective of this article is to compare the current detection technology and introduce the most accurate and rapid ones that are suitable for pandemic circumstances. Hence, the importance of rapid detection in societies is discussed initially. Following this, the current technology for rapid detection of SARS-CoV-2 is explained and classified into three different categories: nucleic acid-based, protein-based, and point of care (PoC) detection testing. Then, the current issues for diagnostic procedures in laboratories are discussed. Finally, the role of new technologies in countering COVID-19 is also introduced to assist researchers in the development of accurate and timely detection of coronaviruses. As coronavirus continues to affect human lives in a detrimental manner, the development of rapid and accurate virus detection methods could promote COVID-19 diagnosis accessible to both individuals and the mass population at patient care. In this regard, rRT-PCR and multiplex RT-PCR detection techniques hold promise.", "doi": "10.1016/j.heliyon.2021.e07247", "pmid": "34124407", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)01350-5"}, {"db": "pmc", "key": "PMC8179727"}], "notes": [], "created": "2021-06-17T07:31:39.185Z", "modified": "2021-06-17T07:31:53.661Z"}, {"entity": "publication", "iuid": "f6daf7ba0a6245ef80f67745d470754a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6daf7ba0a6245ef80f67745d470754a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6daf7ba0a6245ef80f67745d470754a"}}, "title": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process", "authors": [{"family": "Noske", "given": "G D", "initials": "GD"}, {"family": "Nakamura", "given": "A M", "initials": "AM"}, {"family": "Gawriljuk", "given": "V O", "initials": "VO"}, {"family": "Fernandes", "given": "R S", "initials": "RS"}, {"family": "M. A. Lima", "given": "G", "initials": "G"}, {"family": "V. D. Rosa", "given": "H", "initials": "H"}, {"family": "Pereira", "given": "H D", "initials": "HD"}, {"family": "C. M. Zeri", "given": "A", "initials": "A"}, {"family": "A. F. Z. Nascimento", "given": "A", "initials": "A"}, {"family": "C. L. C. Freire", "given": "M", "initials": "M"}, {"family": "Fearon", "given": "D", "initials": "D"}, {"family": "Douangamath", "given": "A", "initials": "A"}, {"family": "von Delft", "given": "F", "initials": "F"}, {"family": "Oliva", "given": "G", "initials": "G"}, {"family": "Godoy", "given": "A S", "initials": "AS"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "Journal of Molecular Biology", "issn": "0022-2836", "pages": "167118", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jmb.2021.167118", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "PDB", "key": "7KFI", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7MBG,", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7KPH", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7N6N", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7LFE", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7LDX", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7LFP", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7KVL", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7N5Z", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7KVR", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}], "notes": [], "created": "2021-06-28T18:07:33.728Z", "modified": "2021-11-18T13:25:03.256Z"}, {"entity": "publication", "iuid": "31a3255454da4e6e98b7717709f33eca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/31a3255454da4e6e98b7717709f33eca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/31a3255454da4e6e98b7717709f33eca"}}, "title": "Political stigma of communicable diseases in complex emergencies.", "authors": [{"family": "Bellizzi", "given": "Saverio", "initials": "S"}, {"family": "Bassat", "given": "Quique", "initials": "Q"}, {"family": "Pichierri", "given": "Giuseppe", "initials": "G"}, {"family": "Cegolon", "given": "Luca", "initials": "L"}, {"family": "Panu Napodano", "given": "Catello Mario", "initials": "CM"}, {"family": "Farina", "given": "Gabriele", "initials": "G"}, {"family": "Murgia", "given": "Paola", "initials": "P"}, {"family": "Ali Maher", "given": "Osama", "initials": "O"}], "type": "journal article", "published": "2021-05-31", "journal": {"title": "J Infect Dev Ctries", "issn": "1972-2680", "volume": "15", "issue": "5", "pages": "747-748", "issn-l": null}, "abstract": null, "doi": "10.3855/jidc.14056", "pmid": "34106901", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-06-10T10:14:27.899Z", "modified": "2021-06-10T10:14:27.909Z"}, {"entity": "publication", "iuid": "81ad5751a2ab4d1d982c75035dc761e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/81ad5751a2ab4d1d982c75035dc761e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/81ad5751a2ab4d1d982c75035dc761e2"}}, "title": "More green, less lonely? A longitudinal cohort study.", "authors": [{"family": "Astell-Burt", "given": "Thomas", "initials": "T"}, {"family": "Hartig", "given": "Terry", "initials": "T"}, {"family": "Eckermann", "given": "Simon", "initials": "S"}, {"family": "Nieuwenhuijsen", "given": "Mark", "initials": "M"}, {"family": "McMunn", "given": "Anne", "initials": "A"}, {"family": "Frumkin", "given": "Howard", "initials": "H"}, {"family": "Feng", "given": "Xiaoqi", "initials": "X"}], "type": "journal article", "published": "2021-05-31", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "issn-l": "0300-5771", "volume": null, "issue": null, "pages": null}, "abstract": "Urban greening may reduce loneliness by offering opportunities for solace, social reconnection and supporting processes such as stress relief. We (i) assessed associations between residential green space and cumulative incidence of, and relief from, loneliness over 4 years; and (ii) explored contingencies by age, sex, disability and cohabitation status.\r\n\r\nMultilevel logistic regressions of change in loneliness status in 8049 city-dwellers between 2013 (baseline) and 2017 (follow-up) in the Household, Income and Labour Dynamics in Australia study. Associations with objectively measured discrete green-space buffers (e.g. parks) (<400, <800 and <1600 m) were adjusted for age, sex, disability, cohabitation status, children and socio-economic variables. Results were translated into absolute risk reductions in loneliness per 10% increase in urban greening.\r\n\r\nThe absolute risk of loneliness rose from 15.9% to 16.9% over the 4 years; however, a 10% increase in urban greening within 1.6 km was associated with lower cumulative incident loneliness [odds ratio (OR) = 0.927, 95% confidence interval (CI) = 0.862 to 0.996; absolute risk reduction = 0.66%]. Stronger association was observed for people living alone (OR = 0.828, 95% CI = 0.725 to 0.944). In comparison to people with <10% green space, the ORs for cumulative incident loneliness were 0.833 (95% CI = 0.695 to 0.997), 0.790 (95% CI = 0.624 to 1.000) and 0.736 (95% CI = 0.549 to 0.986) for 10-20%, 20-30% and >30% green space, respectively. Compared with the <10% green-space reference group with 13.78% incident loneliness over 4 years and conservatively assuming no impact on incident loneliness, associations translated into absolute risk reductions of 1.70%, 2.26% and 2.72% within populations with 10-20%, 20-30% and >30% green space, respectively. These associations were stronger again for people living alone, with 10-20% (OR = 0.608, 95% CI = 0.448 to 0.826), 20-30% (OR = 0.649, 95% CI = 0.436 to 0.966) and >30% (OR = 0.480, 95% CI = 0.278 to 0.829) green space within 1600 m. No age, sex or disability-related contingencies, associations with green space within 400 or 800 m or relief from loneliness reported at baseline were observed.\r\n\r\nA lower cumulative incidence of loneliness was observed among people with more green space within 1600 m of home, especially for people living alone. Potential biopsychosocial mechanisms warrant investigation.", "doi": "10.1093/ije/dyab089", "pmid": "34057994", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "6289969"}], "notes": [], "created": "2021-06-04T11:24:52.062Z", "modified": "2022-11-23T09:00:05.599Z"}, {"entity": "publication", "iuid": "db2bc2a48698482fac8899fdac4646d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db2bc2a48698482fac8899fdac4646d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db2bc2a48698482fac8899fdac4646d5"}}, "title": "Evaluation of Production Lots of a Rapid Point-of-Care Lateral Flow Serological Test Intended for Identification of IgM and IgG against the N-Terminal Part of the Spike Protein (S1) of SARS-CoV-2.", "authors": [{"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Kolstad", "given": "Linda", "initials": "L"}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "journal article", "published": "2021-05-31", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "13", "issue": "6", "pages": null}, "abstract": "The potential of rapid point-of-care (POC) tests has been subject of doubt due to an eventual risk of production errors. The aim was therefore to evaluate the two separate production lots of a commercial POC lateral flow test, intended for the detection of IgM and IgG against the SARS-CoV-2 spike protein (S1). Control samples consisted of serum from individuals with confirmed SARS-CoV-2 infection and pre-COVID-19 negative sera gathered from a biobank. The presence of anti-S1 IgM/IgG in the sera was verified by an in-house Luminex-based serological assay (COVID-19 SIA). One hundred samples were verified as positive for anti-S1 IgG and 74 for anti-S1 IgM. Two hundred samples were verified as negative for anti-S1 IgM/IgG. For the two lots of the POC-test, the sensitivities were 93.2% and 87.8% for IgM and 93.0% and 100% for IgG. The specificities were 100% for IgM and 99.5% for IgG. The positive predictive value was 100% for IgM and 98.9% and 99.0% for IgG. The negative predictive value was 97.6% and 95.7% for IgM, and 96.6% and 100% for IgG. The evaluated POC-test is suitable to assess anti-SARS-CoV-2 S1 IgM and IgG, as a measure of previous virus exposure on an individual level. The external validation of separate lots of rapid POC-tests is encouraged to ensure high sensitivity before market introduction.", "doi": "10.3390/v13061043", "pmid": "34072890", "labels": {"Type: Journal article": null, "Funder: H2020": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Category: Health": null, "Research Area: High-throughput and high-content serology": null}, "xrefs": [{"db": "pii", "key": "v13061043"}], "notes": [], "created": "2021-06-04T11:16:38.767Z", "modified": "2021-08-25T08:16:14.306Z"}, {"entity": "publication", "iuid": "392c272d9fdc407b9613f69a4a167c9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/392c272d9fdc407b9613f69a4a167c9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/392c272d9fdc407b9613f69a4a167c9c"}}, "title": "Implementing Public Health Strategies-The Need for Educational Initiatives: A Systematic Review.", "authors": [{"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}, {"family": "Dulebenets", "given": "Maxim A", "initials": "MA"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}], "type": "journal article", "published": "2021-05-30", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "11", "issn-l": null}, "abstract": "In the absence of a specific treatment or vaccines, public health strategies are the main measures to use in the initial stages of a pandemic to allow surveillance of infectious diseases. During the ongoing global pandemic of coronavirus disease 2019 (COVID-19), several countries initiated various public health strategies, such as contact tracing and quarantine. The present study aims to conduct a systematic literature review to identify the presence of educational initiatives that promote the implementation of public health strategies before public health emergencies, with a special focus on contact tracing applications. Using Science Direct, PubMed, Scopus, and Gothenburg University search engines, all published scientific articles were included, while conference, reports, and non-scientific papers were excluded. The outcomes of the reviewed studies indicate that the effective implementation of public health strategies depends on the peoples' willingness to participate and collaborate with local authorities. Several factors may influence such willingness, of which ethical, psychological, and practical factors seem to be the most important and frequently discussed. Moreover, individual willingness and readiness of a community may also vary based on the acquired level of knowledge about the incident and its cause and available management options. Educational initiatives, proper communication, and timely information at the community level were found to be the necessary steps to counteract misinformation and to promote a successful implementation of public health strategies and attenuate the effects of a pandemic. The systematic review conducted as a part of this study would benefit the relevant stakeholders and policy makers and assist with effective designing and implementation.", "doi": "10.3390/ijerph18115888", "pmid": "34070882", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijerph18115888"}], "notes": [], "created": "2021-06-04T11:17:15.017Z", "modified": "2021-06-04T11:18:07.146Z"}, {"entity": "publication", "iuid": "68875bb1de464d308d1429a8cde63cf1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68875bb1de464d308d1429a8cde63cf1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68875bb1de464d308d1429a8cde63cf1"}}, "title": "The healthier healthcare management models for COVID-19.", "authors": [{"family": "Mishra", "given": "Anshuman", "initials": "A"}, {"family": "Basumallick", "given": "Srijita", "initials": "S"}, {"family": "Lu", "given": "Albert", "initials": "A"}, {"family": "Chiu", "given": "Helen", "initials": "H"}, {"family": "Shah", "given": "Mohammad A", "initials": "MA"}, {"family": "Shukla", "given": "Yogesh", "initials": "Y"}, {"family": "Tiwari", "given": "Ashutosh", "initials": "A"}], "type": "journal article", "published": "2021-05-29", "journal": {"title": "J Infect Public Health", "issn": "1876-035X", "issn-l": null, "volume": "14", "issue": "7", "pages": "927-937"}, "abstract": "The worldwide pandemic situation of COVID-19 generates a situation in which healthcare resources such as diagnostic kits, drugs and basic healthcare infrastructure were on shortage throughout the period, along with negative impact on socio-economic system. Standardized public healthcare models were missing in pandemic situation, covering from hospitalized patient care to local resident's healthcare managements in terms of monitoring, assess to diagnosis and medicines. This exploratory and intervention-based study with the objective of proposing COVID-19 Care Management Model representing comprehensive care of society including patients (COVID-19 and other diseases) and healthy subjects under integrated framework of healthier management model. Shifting policy towards technology-oriented models with well-aligned infrastructure can achieve better outcomes in COVID-19 prevention and care. The planned development of technical healthcare models for prognosis and improved treatment outcomes that take into account not only genomics, proteomics, nanotechnology, materials science perspectives but also the possible contribution of advanced digital technologies is best strategies for early diagnosis and infections control. In view of current pandemic, a Healthier Healthcare Management Model is proposed here as a source of standardized care having technology support, medical consultation, along with public health model of sanitization, distancing and contact less behaviours practices. Effective healthcare managements have been the main driver of healthier society where, positive action at identified research, technology and management segment more specifically public health, patient health, technology selection and political influence has great potential to enhanced the global response to COVID-19. The implementation of such practices will deliver effective diagnosis and control mechanism and make healthier society.", "doi": "10.1016/j.jiph.2021.05.014", "pmid": "34119847", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1876-0341(21)00131-3"}], "notes": [], "created": "2021-06-14T14:22:40.557Z", "modified": "2021-06-17T07:26:04.930Z"}, {"entity": "publication", "iuid": "d4931e50718e4eeb962ecdc1c2af67ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4931e50718e4eeb962ecdc1c2af67ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4931e50718e4eeb962ecdc1c2af67ff"}}, "title": "Immunogenicity of a first dose of mRNA- or vector-based SARS-CoV-2 vaccination in dialysis patients: a multicenter prospective observational pilot study.", "authors": [{"family": "Lesny", "given": "Paul", "initials": "P"}, {"family": "Anderson", "given": "Mark", "initials": "M"}, {"family": "Cloherty", "given": "Gavin", "initials": "G"}, {"family": "Stec", "given": "Michael", "initials": "M"}, {"family": "Haase-Fielitz", "given": "Anja", "initials": "A"}, {"family": "Haarhaus", "given": "Mathias", "initials": "M"}, {"family": "Santos", "given": "Carla", "initials": "C"}, {"family": "Lucas", "given": "Carlos", "initials": "C"}, {"family": "Macario", "given": "Fernando", "initials": "F"}, {"family": "Haase", "given": "Michael", "initials": "M"}], "type": "letter", "published": "2021-05-29", "journal": {"title": "J Nephrol", "issn": "1724-6059", "volume": null, "issue": null, "issn-l": null}, "abstract": "Dialysis patients are at risk for lower SARS-CoV-2-vaccine immunogenicity than the normal population. We assessed immunogenicity to a first mRNA- or vector-based SARS-CoV-2-vaccination dose in dialysis patients.\n\nIn a multicenter observational pilot study, 2 weeks after a first vaccination (BNT162b2/Pfizer-BioNTech [Comirnaty] or ChAdOx1 nCoV-19/Oxford-Astra-Zeneca [Vaxzevria]), hemodialysis patients (N = 23), peritoneal dialysis patients (N = 4) and healthy staff (N = 14) were tested for SARS-CoV-2-spike IgG/IgM, Nucleocapsid-protein-IgG-antibodies and plasma ACE2-receptor-binding-inhibition capacity. Hemodialysis patients who had had prior COVID-19 infection (N = 18) served as controls. Both response to first SARS-CoV-2 vaccination and IgG spike-positivity following prior COVID-19 infection were defined as SARS-CoV-2 spike IgG levels \u2265 50 AU/mL.\n\nVaccination responder rates were 17.4% (4/23) in hemodialysis patients, 100% (4/4) in peritoneal dialysis patients and 57.1% (8/14) in staff (HD vs. PD: p = 0.004, HD vs. staff: p = 0.027). Among hemodialysis patients, type of vaccine (Comirnaty N = 11, Vaxzevria N = 12, 2 responders each) did not appear to influence antibody levels (IgG spike: Comirnaty median 0.0 [1.-3. quartile 0.0-3.8] versus Vaxzevria 4.3 [1.6-20.1] AU/mL, p = 0.079). Of responders to the first dose of SARS-CoV-2 vaccination among hemodialysis patients (N = 4/23), median IgG spike levels and ACE2-receptor-binding-inhibition capacity were lower than that of IgG spike-positive hemodialysis patients with prior COVID-19 infection (13/18, 72.2%): IgG spike: median 222.0, 1.-3. quartile 104.1-721.9 versus median 3794.6, 1.-3. quartile 793.4-9357.9 AU/mL, p = 0.015; ACE2-receptor-binding-inhibition capacity: median 11.5%, 1.-3. quartile 5.0-27.3 versus median 74.8%, 1.-3. quartile 44.9-98.1, p = 0.002.\n\nTwo weeks after their first mRNA- or vector-based SARS-CoV-2 vaccination, hemodialysis patients demonstrated lower antibody-related response than peritoneal dialysis patients and healthy staff or unvaccinated hemodialysis patients following prior COVID-19 infection.", "doi": "10.1007/s40620-021-01076-0", "pmid": "34050904", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40620-021-01076-0"}, {"db": "pmc", "key": "PMC8164063"}], "notes": [], "created": "2021-06-04T11:36:25.252Z", "modified": "2021-06-04T11:36:25.255Z"}, {"entity": "publication", "iuid": "2a3f46daaab347e1ae1cf81f945c32df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2a3f46daaab347e1ae1cf81f945c32df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2a3f46daaab347e1ae1cf81f945c32df"}}, "title": "High-throughput immunoassays for SARS-CoV-2 - considerable differences in performance when comparing three methods.", "authors": [{"family": "Ekelund", "given": "Oskar", "initials": "O"}, {"family": "Ekblom", "given": "Kim", "initials": "K"}, {"family": "Somajo", "given": "Sofia", "initials": "S"}, {"family": "Pattison-Granberg", "given": "Johanna", "initials": "J"}, {"family": "Olsson", "given": "Karl", "initials": "K"}, {"family": "Petersson", "given": "Annika", "initials": "A"}], "type": "journal article", "published": "2021-05-29", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "volume": null, "issue": null, "pages": "1-6", "issn-l": "2374-4235"}, "abstract": "The recently launched high-throughput assays for detecting antibodies against SARS-CoV-2 has contributed to the managing strategies for the COVID-19 pandemic. This study aimed to investigate the performance of three high-throughput assays and one rapid lateral flow test relative to regulatory authorities' recommended criteria.\n\nA total of 315 samples, including 150 pre-pandemic samples, 152 samples from SARS-CoV-2 RT-PCR positive individuals and 13 potentially cross-reactive samples were analysed with SARS-CoV-2 IgG (Abbott, Abbott Park, IL), Elecsys Anti-SARS-CoV-2 (Roche, Solna, Sweden), LIAISON SARS-CoV-2 S1/S2 IgG (DiaSorin, Saluggia, Italy) and 2019-nCOV IgG/IgM Rapid Test (Dynamiker Biotechnology Co., Tianjin, China).\n\nAll assays performed with a high level of specificity ranging from 96.7% to 99.3%. Sensitivity differed more between the assays, Roche exhibiting the highest sensitivity of 98.7%. The corresponding figures for Abbott, DiaSorin and Dynamiker Biotechnology were 80.9%, 89.0% and 72.4%, respectively.\n\nThe results of the evaluated SARS-CoV-2 assays vary considerably, as well as their ability to fulfil the performance criteria proposed by regulatory authorities. Introduction into clinical use in low-prevalent settings, should, therefore, be made with caution.", "doi": "10.1080/23744235.2021.1931434", "pmid": "34053400", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Proteins": null}, "xrefs": [], "notes": [], "created": "2021-06-04T11:30:48.052Z", "modified": "2021-06-04T11:30:48.055Z"}, {"entity": "publication", "iuid": "d1b37ba4b2974fd7a47738328a38bcc7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1b37ba4b2974fd7a47738328a38bcc7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1b37ba4b2974fd7a47738328a38bcc7"}}, "title": "Dysregulation of COVID-19 related gene expression in the COPD lung.", "authors": [{"family": "Watson", "given": "Alastair", "initials": "A"}, {"family": "\u00d6berg", "given": "Lisa", "initials": "L"}, {"family": "Angermann", "given": "Bastian", "initials": "B"}, {"family": "Spalluto", "given": "C Mirella", "initials": "CM"}, {"family": "H\u00fchn", "given": "Michael", "initials": "M"}, {"family": "Burke", "given": "Hannah", "initials": "H"}, {"family": "Cellura", "given": "Doriana", "initials": "D"}, {"family": "Freeman", "given": "Anna", "initials": "A"}, {"family": "Muthas", "given": "Daniel", "initials": "D"}, {"family": "Etal", "given": "Damla", "initials": "D"}, {"family": "Belfield", "given": "Graham", "initials": "G"}, {"family": "Karlsson", "given": "Fredrik", "initials": "F"}, {"family": "Nordstr\u00f6m", "given": "Karl", "initials": "K"}, {"family": "Ostridge", "given": "Kris", "initials": "K"}, {"family": "Staples", "given": "Karl J", "initials": "KJ"}, {"family": "Wilkinson", "given": "Tom", "initials": "T"}, {"family": "MICA II Studygroup", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-29", "journal": {"title": "Respir Res", "issn": "1465-993X", "volume": "22", "issue": "1", "pages": "164", "issn-l": "1465-9921"}, "abstract": "Chronic obstructive pulmonary disease (COPD) patients are at increased risk of poor outcome from Coronavirus disease (COVID-19). Early data suggest elevated Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) receptor angiotensin converting enzyme 2 (ACE2) expression, but relationships to disease phenotype and downstream regulators of inflammation in the Renin-Angiotensin system (RAS) are unknown. We aimed to determine the relationship between RAS gene expression relevant to SARS-CoV-2 infection in the lung with disease characteristics in COPD, and the regulation of newly identified SARS-CoV-2 receptors and spike-cleaving proteases, important for SARS-CoV-2 infection.\n\nWe quantified gene expression using RNA sequencing of epithelial brushings and bronchial biopsies from 31 COPD and 37 control subjects.\n\nACE2 gene expression (log2-fold change (FC)) was increased in COPD compared to ex-smoking (HV-ES) controls in epithelial brushings (0.25, p = 0.042) and bronchial biopsies (0.23, p = 0.050), and correlated with worse lung function (r = - 0.28, p = 0.0090). ACE2 was further increased in frequent exacerbators compared to infrequent exacerbators (0.51, p = 0.00045) and associated with use of ACE inhibitors (ACEi) (0.50, p = 0.0034), having cardiovascular disease (0.23, p = 0.048) or hypertension (0.34, p = 0.0089), and inhaled corticosteroid use in COPD subjects in bronchial biopsies (0.33, p = 0.049). Angiotensin II receptor type (AGTR)1 and 2 expression was decreased in COPD bronchial biopsies compared to HV-ES controls with log2FC of -0.26 (p = 0.033) and - 0.40, (p = 0.0010), respectively. However, the AGTR1:2 ratio was increased in COPD subjects compared with HV-ES controls, log2FC of 0.57 (p = 0.0051). Basigin, a newly identified potential SARS-CoV-2 receptor was also upregulated in both brushes, log2FC of 0.17 (p = 0.0040), and bronchial biopsies, (log2FC of 0.18 (p = 0.017), in COPD vs HV-ES. Transmembrane protease, serine (TMPRSS)2 was not differentially regulated between control and COPD. However, various other spike-cleaving proteases were, including TMPRSS4 and Cathepsin B, in both epithelial brushes (log2FC of 0.25 (p = 0.0012) and log2FC of 0.56 (p = 5.49E-06), respectively) and bronchial biopsies (log2FC of 0.49 (p = 0.00021) and log2FC of 0.246 (p = 0.028), respectively).\n\nThis study identifies key differences in expression of genes related to susceptibility and aetiology of COVID-19 within the COPD lung. Further studies to understand the impact on clinical course of disease are now required.", "doi": "10.1186/s12931-021-01755-3", "pmid": "34051791", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12931-021-01755-3"}], "notes": [], "created": "2021-06-04T11:33:58.818Z", "modified": "2021-06-04T11:35:52.210Z"}, {"entity": "publication", "iuid": "da0a1e3edde34e98982fa9faf6c59de4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/da0a1e3edde34e98982fa9faf6c59de4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/da0a1e3edde34e98982fa9faf6c59de4"}}, "title": "What drives transmission of severe acute respiratory syndrome coronavirus 2?", "authors": [{"family": "Andersson", "given": "Jan", "initials": "J"}], "type": "editorial", "published": "2021-05-28", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": null, "issue": null, "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic represents the most severe public health crisis of the last 100 years both in terms of societal impact and illness. As of May 10 th more than 155 million individuals have contracted COVID-19 and more than 3,3 million have died from the disease. Even though the underlying pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a member of the coronavirus family that has been studied extensively for many decades, the world was ill-prepared to deal with its high degree of contagion combined with its broad spectrum of virulence. Regretfully, knowledge gained about the physical underpinnings of respiratory viral transmission after the 1918 Spanish flu pandemic was largely ignored by the public health community at the outset of the COVID-19 pandemic.", "doi": "10.1111/joim.13335", "pmid": "34048113", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-29T16:28:03.282Z", "modified": "2021-05-29T16:28:03.294Z"}, {"entity": "publication", "iuid": "6908fbc9bddc495a9c868ac16f0fbc33", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6908fbc9bddc495a9c868ac16f0fbc33.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6908fbc9bddc495a9c868ac16f0fbc33"}}, "title": "Prevalence and Predictors of Loneliness Among Youth During the Time of COVID-19: A Multinational Study.", "authors": [{"family": "Al Omari", "given": "Omar", "initials": "O"}, {"family": "Al Sabei", "given": "Sulaiman", "initials": "S"}, {"family": "Al Rawajfah", "given": "Omar", "initials": "O"}, {"family": "Abu Sharour", "given": "Loai", "initials": "L"}, {"family": "Al-Hashmi", "given": "Iman", "initials": "I"}, {"family": "Al Qadire", "given": "Mohammad", "initials": "M"}, {"family": "Khalaf", "given": "Atika", "initials": "A"}], "type": "journal article", "published": "2021-05-28", "journal": {"title": "J Am Psychiatr Nurses Assoc", "issn": "1532-5725", "volume": null, "issue": null, "pages": "10783903211017640", "issn-l": null}, "abstract": "Given the restrictions associated with COVID-19, feelings of loneliness among youth may increase.\n\nThe aims of the current study were to assess the prevalence of loneliness among young people at the time of COVID-19 and to identify whether selected variables related to the pandemic predicted the level of loneliness.\n\nA cross-sectional study using WhatsApp and Facebook social media platforms was conducted to survey 1,057 young people aged 15 to 24 years from six Middle Eastern countries. Participants completed survey items including demographic and COVID-19-related questions; the Depression, Anxiety and Stress Scale (DASS); the Satisfaction With Life Scale (SWLS); and the UCLA Loneliness Scale.\n\nThe prevalence of experienced loneliness was 1 (0.1%), 625 (59.1%), 429 (40.6%), and 2 (0.2%), reflecting low, moderate, moderately high, and high experiences for loneliness, respectively. History of depression or anxiety, being dissatisfied with life, and having depression at the time of COVID-19 were significant predictors of loneliness among youth. The model was significant ( F = 44.95, p < .05) and accounted for 29.8% of the variance in UCLA Loneliness Scale scores.\n\nWe found that the high prevalence rate of loneliness during the COVID-19 pandemic was correlated with depression and impaired life satisfaction among Middle Eastern youth. Thus, special attention and interventional action plans need to be developed taking into consideration the youths' special situation during COVID-19.", "doi": "10.1177/10783903211017640", "pmid": "34047225", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-29T15:22:40.898Z", "modified": "2021-05-29T15:22:40.921Z"}, {"entity": "publication", "iuid": "49d31b83abc549c9b2c040fa0690d771", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49d31b83abc549c9b2c040fa0690d771.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49d31b83abc549c9b2c040fa0690d771"}}, "title": "Letter to the editor regarding the Topical Review \"Silent hypoxaemia in COVID-19 patients\" by Simonson et al. 2021.", "authors": [{"family": "Mulder", "given": "Eric", "initials": "E"}, {"family": "Pernett", "given": "Frank", "initials": "F"}, {"family": "Schagatay", "given": "Erika", "initials": "E"}], "type": "letter", "published": "2021-05-28", "journal": {"title": "J Physiol", "issn": "1469-7793", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1113/JP281882", "pmid": "34047369", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-29T15:21:48.640Z", "modified": "2021-05-29T15:21:48.656Z"}, {"entity": "publication", "iuid": "4bddd32590714a84adae0eb53060c511", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4bddd32590714a84adae0eb53060c511.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4bddd32590714a84adae0eb53060c511"}}, "title": "Incidence and Severity of Covid-19 in Patients with and without Previously Verified Infections with Common Cold Coronaviruses.", "authors": [{"family": "Ringlander", "given": "Johan", "initials": "J", "orcid": "0000-0002-8483-6504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64f85af7dceb436498422e62f1a98c89.json"}}, {"family": "Martner", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Westin", "given": "Johan", "initials": "J"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K"}], "type": "letter", "published": "2021-05-28", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899", "volume": "223", "issue": "10", "pages": "1831-1832"}, "abstract": null, "doi": "10.1093/infdis/jiab089", "pmid": "33780548", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6199850"}, {"db": "pmc", "key": "PMC8083637"}], "notes": [], "created": "2021-03-31T08:12:57.627Z", "modified": "2021-06-14T14:21:11.954Z"}, {"entity": "publication", "iuid": "95af6fdd90c945bb8a6026c4fd1d2092", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95af6fdd90c945bb8a6026c4fd1d2092.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95af6fdd90c945bb8a6026c4fd1d2092"}}, "title": "Associations of baseline use of biologic or targeted synthetic DMARDs with COVID-19 severity in rheumatoid arthritis: Results from the COVID-19 Global Rheumatology Alliance physician registry.", "authors": [{"family": "Sparks", "given": "Jeffrey A", "initials": "JA"}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Seet", "given": "Andrea M", "initials": "AM"}, {"family": "Gianfrancesco", "given": "Milena A", "initials": "MA"}, {"family": "Izadi", "given": "Zara", "initials": "Z"}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL"}, {"family": "Strangfeld", "given": "Anja", "initials": "A"}, {"family": "Gossec", "given": "Laure", "initials": "L"}, {"family": "Carmona", "given": "Loreto", "initials": "L"}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S"}, {"family": "Trupin", "given": "Laura", "initials": "L"}, {"family": "Rush", "given": "Stephanie", "initials": "S"}, {"family": "Katz", "given": "Patricia", "initials": "P"}, {"family": "Schmajuk", "given": "Gabriela", "initials": "G"}, {"family": "Jacobsohn", "given": "Lindsay", "initials": "L"}, {"family": "Wise", "given": "Leanna", "initials": "L"}, {"family": "Gilbert", "given": "Emily L", "initials": "EL"}, {"family": "Duarte-Garc\u00eda", "given": "Ali", "initials": "A"}, {"family": "Valenzuela-Almada", "given": "Maria O", "initials": "MO"}, {"family": "Pons-Estel", "given": "Guillermo J", "initials": "GJ"}, {"family": "Isnardi", "given": "Carolina A", "initials": "CA"}, {"family": "Berbotto", "given": "Guillermo A", "initials": "GA"}, {"family": "Hsu", "given": "Tiffany Y-T", "initials": "TY"}, {"family": "D'Silva", "given": "Kristin M", "initials": "KM"}, {"family": "Patel", "given": "Naomi J", "initials": "NJ"}, {"family": "Kearsley-Fleet", "given": "Lianne", "initials": "L"}, {"family": "Sch\u00e4fer", "given": "Martin", "initials": "M"}, {"family": "Ribeiro", "given": "Sandra L\u00facia Euz\u00e9bio", "initials": "SLE"}, {"family": "Al Emadi", "given": "Samar", "initials": "S"}, {"family": "Tidblad", "given": "Liselotte", "initials": "L"}, {"family": "Scir\u00e8", "given": "Carlo Alberto", "initials": "CA"}, {"family": "Raffeiner", "given": "Bernd", "initials": "B"}, {"family": "Thomas", "given": "Thierry", "initials": "T"}, {"family": "Flipo", "given": "Ren\u00e9-Marc", "initials": "RM"}, {"family": "Avouac", "given": "J\u00e9r\u00f4me", "initials": "J"}, {"family": "Seror", "given": "Rapha\u00e8le", "initials": "R"}, {"family": "Bernardes", "given": "Miguel", "initials": "M"}, {"family": "Cunha", "given": "Maria Margarida", "initials": "MM"}, {"family": "Hasseli", "given": "Rebecca", "initials": "R"}, {"family": "Schulze-Koops", "given": "Hendrik", "initials": "H"}, {"family": "M\u00fcller-Ladner", "given": "Ulf", "initials": "U"}, {"family": "Specker", "given": "Christof", "initials": "C"}, {"family": "Souza", "given": "Viviane Angelina de", "initials": "VA"}, {"family": "Mota", "given": "Licia Maria Henrique da", "initials": "LMHD"}, {"family": "Gomides", "given": "Ana Paula Monteiro", "initials": "APM"}, {"family": "Dieud\u00e9", "given": "Philippe", "initials": "P"}, {"family": "Nikiphorou", "given": "Elena", "initials": "E"}, {"family": "Kronzer", "given": "Vanessa L", "initials": "VL"}, {"family": "Singh", "given": "Namrata", "initials": "N"}, {"family": "Ugarte-Gil", "given": "Manuel F", "initials": "MF"}, {"family": "Wallace", "given": "Beth", "initials": "B"}, {"family": "Akpabio", "given": "Akpabio", "initials": "A"}, {"family": "Thomas", "given": "Ranjeny", "initials": "R"}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Costello", "given": "Wendy", "initials": "W"}, {"family": "Grainger", "given": "Rebecca", "initials": "R"}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS"}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Sufka", "given": "Paul", "initials": "P"}, {"family": "Robinson", "given": "Philip C", "initials": "PC"}, {"family": "Machado", "given": "Pedro M", "initials": "PM"}, {"family": "Yazdany", "given": "Jinoos", "initials": "J"}, {"family": "COVID-19 Global Rheumatology Alliance", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-28", "journal": {"title": "Ann Rheum Dis", "issn": "1468-2060", "volume": null, "issue": null, "issn-l": null}, "abstract": "To investigate baseline use of biologic or targeted synthetic (b/ts) disease-modifying antirheumatic drugs (DMARDs) and COVID-19 outcomes in rheumatoid arthritis (RA).\n\nWe analysed the COVID-19 Global Rheumatology Alliance physician registry (from 24 March 2020 to 12 April 2021). We investigated b/tsDMARD use for RA at the clinical onset of COVID-19 (baseline): abatacept (ABA), rituximab (RTX), Janus kinase inhibitors (JAKi), interleukin 6 inhibitors (IL-6i) or tumour necrosis factor inhibitors (TNFi, reference group). The ordinal COVID-19 severity outcome was (1) no hospitalisation, (2) hospitalisation without oxygen, (3) hospitalisation with oxygen/ventilation or (4) death. We used ordinal logistic regression to estimate the OR (odds of being one level higher on the ordinal outcome) for each drug class compared with TNFi, adjusting for potential baseline confounders.\n\nOf 2869 people with RA (mean age 56.7 years, 80.8% female) on b/tsDMARD at the onset of COVID-19, there were 237 on ABA, 364 on RTX, 317 on IL-6i, 563 on JAKi and 1388 on TNFi. Overall, 613 (21%) were hospitalised and 157 (5.5%) died. RTX (OR 4.15, 95% CI 3.16 to 5.44) and JAKi (OR 2.06, 95% CI 1.60 to 2.65) were each associated with worse COVID-19 severity compared with TNFi. There were no associations between ABA or IL6i and COVID-19 severity.\n\nPeople with RA treated with RTX or JAKi had worse COVID-19 severity than those on TNFi. The strong association of RTX and JAKi use with poor COVID-19 outcomes highlights prioritisation of risk mitigation strategies for these people.", "doi": "10.1136/annrheumdis-2021-220418", "pmid": "34049860", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "annrheumdis-2021-220418"}], "notes": [], "created": "2021-06-04T11:39:56.896Z", "modified": "2021-06-04T11:39:56.913Z"}, {"entity": "publication", "iuid": "20a58e6949654e17abb103cef04c1ee9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/20a58e6949654e17abb103cef04c1ee9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/20a58e6949654e17abb103cef04c1ee9"}}, "title": "Acuity level of care as a predictor of case fatality and prolonged hospital stay in patients with COVID-19: a hospital-based observational follow-up study from Pakistan.", "authors": [{"family": "Almas", "given": "Aysha", "initials": "A"}, {"family": "Mushtaq", "given": "Zain", "initials": "Z"}, {"family": "Moller", "given": "Jette", "initials": "J"}], "type": "journal article", "published": "2021-05-28", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "5", "pages": "e045414"}, "abstract": "To determine if there is an association between acuity level of care (ALC), case fatality and length of stay in patients admitted to hospital due to COVID-19.\r\n\r\nA hospital-based observational follow-up study.\r\n\r\nInternal Medicine Service of the Aga Khan University Hospital, Pakistan, from 26 February 2020 to 30 June 2020.\r\n\r\nAdult patients with confirmed COVID-19, aged \u226518 years.\r\n\r\nALC was categorised into low, intermediate and high level and patients were triaged using the standard emergency severity illness score. All patients were followed until the end of hospital admission for the outcome of case fatality and length of stay.\r\n\r\nA total of 822 patients with COVID-19 were admitted during the study period and 699 met inclusion criteria. The mean age was 54.5 years and 67% were males; 50.4% were triaged to low, 42.5% to intermediate and 7.2% to high acuity care. The overall case-fatality rate was 11.6%, with the highest (52%) in high acuity level followed by 16.2% in intermediate and 2% in low acuity care. Acuity level was associated with case fatality, with an HR (95% CI) of 5.0 (2.0 to 12.1) for high versus low acuity care and an HR of 2.7 (1.2, 6.4) for intermediate versus low acuity care, after adjusting for age, sex and common comorbidities including diabetes, hypertension, ischaemic heart disease and chronic lung disease. Similarly, acuity level was also associated with length of hospital stay.\r\n\r\nHigh and intermediate acuity level is associated with higher case fatality rate and prolonged length of hospital stay in patients admitted with COVID-19. In resource-limited settings where the provision of high acuity care is limited, the intermediate care acuity could serve as a useful strategy to treat relatively less critical patients with COVID-19.", "doi": "10.1136/bmjopen-2020-045414", "pmid": "34049912", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-045414"}], "notes": [], "created": "2021-06-04T11:39:03.792Z", "modified": "2021-07-14T09:07:44.390Z"}, {"entity": "publication", "iuid": "428c57c97b5143e58cc7f7f5d705cb70", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/428c57c97b5143e58cc7f7f5d705cb70.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/428c57c97b5143e58cc7f7f5d705cb70"}}, "title": "Mortality in adult patients with solid or hematological malignancies and SARS-CoV-2 infection with a specific focus on lung and breast malignancies: a systematic review and meta-analysis.", "authors": [{"family": "Tagliamento", "given": "Marco", "initials": "M"}, {"family": "Agostinetto", "given": "Elisa", "initials": "E"}, {"family": "Bruzzone", "given": "Marco", "initials": "M"}, {"family": "Ceppi", "given": "Marcello", "initials": "M"}, {"family": "Saini", "given": "Kamal S", "initials": "KS"}, {"family": "de Azambuja", "given": "Evandro", "initials": "E"}, {"family": "Punie", "given": "Kevin", "initials": "K"}, {"family": "Westphalen", "given": "C Benedikt", "initials": "CB"}, {"family": "Morgan", "given": "Gilberto", "initials": "G"}, {"family": "Pronzato", "given": "Paolo", "initials": "P"}, {"family": "Del Mastro", "given": "Lucia", "initials": "L"}, {"family": "Poggio", "given": "Francesca", "initials": "F"}, {"family": "Lambertini", "given": "Matteo", "initials": "M"}], "type": "journal article", "published": "2021-05-27", "journal": {"title": "Crit Rev Oncol Hematol", "issn": "1879-0461", "volume": null, "issue": null, "pages": "103365", "issn-l": null}, "abstract": "A systematic review and meta-analysis were performed to estimate the mortality in patients with cancer and SARS-CoV-2 infection.\n\nA systematic search of PubMed, up to 31 January 2021, identified publications reporting the case-fatality rate (CFR) among adult patients with solid and/or hematological malignancies and SARS-CoV-2 infection. The CFR, defined as the rate of death among this population, was assessed with a random effect model; 95% confidence intervals (CI) were calculated.\n\nAmong 135 selected studies (N = 33,879 patients), the CFR was 25.4% (95% CI 22.9%-28.2%). At a sensitivity analysis of studies with at least 100 patients, the CFR was 21.9% (95% CI 19.1%-25.1%). Among COVID-19 patients with lung (N = 1,135) and breast (N = 1,296) cancers, CFR were 32.4% (95% CI 26.5%-39.6%) and 14.2% (95% CI 9.3%-21.8%), respectively.\n\nCOVID-19 patients with lung cancer have a comparatively higher probability of mortality than those with breast cancer.", "doi": "10.1016/j.critrevonc.2021.103365", "pmid": "34052423", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1040-8428(21)00153-0"}], "notes": [], "created": "2021-05-31T16:10:57.629Z", "modified": "2021-06-04T11:33:13.590Z"}, {"entity": "publication", "iuid": "937f550349b9447aa382b9d0ae959148", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/937f550349b9447aa382b9d0ae959148.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/937f550349b9447aa382b9d0ae959148"}}, "title": "Iatrogenic immunosuppression can lead to prolonged viral shedding and absent immune response to COVID-19.", "authors": [{"family": "Psaros Einberg", "given": "A", "initials": "A"}, {"family": "Casswall", "given": "T", "initials": "T"}, {"family": "Arnell", "given": "H", "initials": "H"}, {"family": "Nowak", "given": "G", "initials": "G"}, {"family": "Mirazimi", "given": "A", "initials": "A"}, {"family": "Sundin", "given": "M", "initials": "M"}, {"family": "Fischler", "given": "B", "initials": "B"}], "type": "journal article", "published": "2021-05-27", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": null, "issue": null, "issn-l": "0803-5253"}, "abstract": "In the era of the COVID-19 pandemic, paediatricians need to remember that immunocompromised children might experience prolonged viral shedding and impaired immunological response to SARS-CoV-2. We report a girl diagnosed with an unresectable angiosarcoma of the liver who underwent liver transplantation in June 2019. The basic immunosuppression protocol consisted of tacrolimus and prednisolone. Additionally, she was on adjuvant treatment with trametinib, a mitogen-activated protein kinase (MEK) inhibitor.", "doi": "10.1111/apa.15955", "pmid": "34043855", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-29T15:27:50.514Z", "modified": "2021-05-29T15:28:08.933Z"}, {"entity": "publication", "iuid": "c1a5506828024e04a38f14fd2e79843d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1a5506828024e04a38f14fd2e79843d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1a5506828024e04a38f14fd2e79843d"}}, "title": "Fostering local involvement for biodiversity conservation in tropical regions: Lessons from Madagascar during the COVID-19 pandemic.", "authors": [{"family": "Razanatsoa", "given": "Estelle", "initials": "E", "orcid": "0000-0002-7219-1411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/454a8b9297fc49e28b40309d49f0f20a.json"}}, {"family": "Andriantsaralaza", "given": "Seheno", "initials": "S", "orcid": "0000-0002-6098-2056", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22ed6f4d679f4b7586604bdeaab878b1.json"}}, {"family": "Holmes", "given": "Sheila M", "initials": "SM", "orcid": "0000-0002-6420-5510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b17dfb2bb1174ca7a174d8f163e137f4.json"}}, {"family": "Rakotonarivo", "given": "O Sarobidy", "initials": "OS", "orcid": "0000-0002-8032-1431", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/836e1a64ab9a406d815ac9eae8407e30.json"}}, {"family": "Ratsifandrihamanana", "given": "Anitry N", "initials": "AN"}, {"family": "Randriamiharisoa", "given": "Lalatiana", "initials": "L"}, {"family": "Ravaloharimanitra", "given": "Maholy", "initials": "M"}, {"family": "Ramahefamanana", "given": "Narindra", "initials": "N"}, {"family": "Tahirinirainy", "given": "Dinasoa", "initials": "D"}, {"family": "Raharimampionona", "given": "Jeannie", "initials": "J"}], "type": "journal article", "published": "2021-05-27", "journal": {"title": "Biotropica", "issn": "0006-3606", "issn-l": null}, "abstract": "Tropical ecosystems host a large proportion of global biodiversity and directly support the livelihoods of many of the world's poorest, and often marginalized, people through ecosystem goods and services and conservation employment. The coronavirus pandemic has challenged existing conservation structures and management but provides an opportunity to re-examine strategies and research approaches across the tropics to build resilience for future crises. Based on the personal experiences of conservation leaders, managers, and researchers from Madagascar during this period, we discuss the coping strategies of multiple biodiversity conservation organizations during the coronavirus pandemic. We highlight the vital role of local communities in building and maintaining resilient conservation practices that are robust to global disruptions such as the COVID-19 crisis. We argue that the integration of local experts and communities in conservation, research, and financial decision-making is essential to a strong foundation for biodiversity conservation in developing countries to stand up to future environmental, political, and health crises. This integration could be achieved through the support of training and capacity building of local researchers and community members and these actions would also enhance the development of strong, equitable long-term collaborations with international communities. Equipped with such capacity, conservationists and researchers from these regions could establish long-term biodiversity conservation strategies that are adapted to local context, and communities could flexibly balance biodiversity and livelihood needs as circumstances change, including weathering the isolation and financial challenges of local or global crises.", "doi": "10.1111/btp.12967", "pmid": "34219750", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "BTP12967"}, {"db": "pmc", "key": "PMC8239783"}], "notes": [], "created": "2021-08-06T08:53:44.583Z", "modified": "2021-08-06T08:53:59.254Z"}, {"entity": "publication", "iuid": "8767c26e5c524de09e1225c60e4f29eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8767c26e5c524de09e1225c60e4f29eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8767c26e5c524de09e1225c60e4f29eb"}}, "title": "Vaccine Inequities, Intellectual Property Rights and Pathologies of Power in the Global Response to COVID-19.", "authors": [{"family": "Engebretsen", "given": "Eivind", "initials": "E", "orcid": "0000-0001-9455-110X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fce6bb59db844a65b3c378ae1e97d867.json"}}, {"family": "Ottersen", "given": "Ole Petter", "initials": "OP"}], "type": "journal article", "published": "2021-05-26", "journal": {"title": "Int J Health Policy Manag", "issn": "2322-5939", "issn-l": null}, "abstract": null, "doi": "10.34172/ijhpm.2021.57", "pmid": "34124871", "labels": [], "xrefs": [], "notes": [], "created": "2021-06-17T07:43:43.010Z", "modified": "2021-06-17T07:43:43.047Z"}, {"entity": "publication", "iuid": "1e4e8c46e7ca4527a361f0c9b526b8d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1e4e8c46e7ca4527a361f0c9b526b8d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1e4e8c46e7ca4527a361f0c9b526b8d0"}}, "title": "Risk of stress/depression and functional impairment in Denmark immediately following a COVID-19 shutdown.", "authors": [{"family": "Andersen", "given": "Lars H", "initials": "LH"}, {"family": "Fallesen", "given": "Peter", "initials": "P"}, {"family": "Bruckner", "given": "Tim A", "initials": "TA"}], "type": "journal article", "published": "2021-05-26", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "984"}, "abstract": "Existing estimates of the impact of the COVID-19 burden on mental wellbeing come from countries with high mortality rates. This study therefore aimed to investigate the impact of the first COVID-19 lockdown (March-April 2020) on risk for stress/depression and functional impairment in a representative sample of adult individuals in Denmark, which had lower infection rates, and whether the impact of lockdown was heterogeneous across living situation.\r\n\r\nUsing a representative, randomly drawn sample from the complete Danish adult population interviewed in March 2 to April 13, 2020 (n = 2836) and again in July 2020 (n = 1526, 54% retention rate), we study how the imposed lockdown announced March 11 following the onset of the first Danish wave of COVID-19 infections affected mental wellbeing. We use the World Health Organization Five Well-being Index (WHO-5) and the Work and Social Adjustment Scale (WSAS) to capture risk for stress/depression (WHO-5 < 50) and functional impairment (WSAS > 10). Using covariate adjusted ordinary least squares linear probability models and exploiting variation in the timing of responses occurring just before and just after the introduction of lockdown, we compare respondents before lockdown to respondents that answered during lockdown, as well as to answers in re-interviews in July.\r\n\r\nIn our fully controlled models, we find reduced depressive symptoms among adults immediately after the shutdown, concentrated in adults with children living at home (-.089, p < .01 (from pre lockdown baseline .273)). Measures of functional impairment also declined immediately after the March shutdown among adults with children living at home (-.066, p < .05 (from pre lockdown baseline .150)). Impairment intensified for the entire sample between March and July (+.199, p < .001 (from pre lockdown baseline .248)), but depressive symptoms remained at lower rate in July (-.033, p < .05 (from pre lockdown baseline .332).\r\n\r\nFindings in Denmark indicate that living with children at home may have, in the short term, buffered the potential mental health sequelae of the COVID-19 shutdown.", "doi": "10.1186/s12889-021-11020-3", "pmid": "34039323", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11020-3"}], "notes": [], "created": "2021-05-29T15:31:51.419Z", "modified": "2022-11-23T09:00:29.216Z"}, {"entity": "publication", "iuid": "c4684de637ff43ec912ca70bf831a82a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c4684de637ff43ec912ca70bf831a82a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c4684de637ff43ec912ca70bf831a82a"}}, "title": "Fostering global data sharing: highlighting the recommendations of the Research Data Alliance COVID-19 working group", "authors": [{"family": "Austin", "given": "Claire C", "initials": "CC", "orcid": "0000-0001-9138-5986", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c6b7cea2c224961825b7986b7d1f17f.json"}}, {"family": "Bernier", "given": "Alexander", "initials": "A", "orcid": "0000-0001-8615-8375", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93d210c6bb9047daa58cfe87dc53fe52.json"}}, {"family": "Bezuidenhout", "given": "Louise", "initials": "L", "orcid": "0000-0003-4328-3963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b9fce97de2e4f54b82b06d20695e735.json"}}, {"family": "Bicarregui", "given": "Juan", "initials": "J", "orcid": "0000-0001-5250-7653", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69a0641e17eb47058ac58941c180586b.json"}}, {"family": "Biro", "given": "Timea", "initials": "T", "orcid": "0000-0002-8900-8978", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e00a6f3933b485898c9524dd5f9dc3a.json"}}, {"family": "Cambon-Thomsen", "given": "Anne", "initials": "A", "orcid": "0000-0001-8793-3644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96673088e61d4699a4197088c6eba954.json"}}, {"family": "Carroll", "given": "Stephanie Russo", "initials": "SR", "orcid": "0000-0002-8996-8071", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bbcfdde655a4415f8a1198811932af90.json"}}, {"family": "Cournia", "given": "Zoe", "initials": "Z", "orcid": "0000-0001-9287-364X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8a80098a1fa4268b4b7321618482e8b.json"}}, {"family": "Dabrowski", "given": "Piotr Wojciech", "initials": "PW", "orcid": "0000-0003-4893-805X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c7b5d2b1ed846538c5d183782864a3c.json"}}, {"family": "Diallo", "given": "Gayo", "initials": "G"}, {"family": "Duflot", "given": "Thomas", "initials": "T", "orcid": "0000-0002-8730-284X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c0158acd3a34521a3fbd36f0ef1d823.json"}}, {"family": "Garcia", "given": "Leyla", "initials": "L", "orcid": "0000-0003-3986-0510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0e247431cfc446599995c672f5d89bc.json"}}, {"family": "Gesing", "given": "Sandra", "initials": "S"}, {"family": "Gonzalez-Beltran", "given": "Alejandra", "initials": "A", "orcid": "0000-0003-3499-8262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12ad5713a3324f83915b8136aa7e43b5.json"}}, {"family": "Gururaj", "given": "Anupama", "initials": "A", "orcid": "0000-0002-4221-4379", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab358e34447c439d90a0cbcf488ccd4f.json"}}, {"family": "Harrower", "given": "Natalie", "initials": "N", "orcid": "0000-0002-7487-4881", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/466ab83cba30459dbe96c178cc371f50.json"}}, {"family": "Lin", "given": "Dawei", "initials": "D"}, {"family": "Medeiros", "given": "Claudia", "initials": "C", "orcid": "0000-0003-1908-4753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f57ea5f61e384f458245e5f83e5124ac.json"}}, {"family": "M\u00e9ndez", "given": "Eva", "initials": "E", "orcid": "0000-0002-5337-4722", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e2ac979f16f44beb29275697c0bba62.json"}}, {"family": "Meyers", "given": "Natalie", "initials": "N", "orcid": "0000-0001-6441-6716", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3261010fd1d5419aab0011cf7347b86d.json"}}, {"family": "Mietchen", "given": "Daniel", "initials": "D", "orcid": "0000-0001-9488-1870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5c738bfdab3d4c53a35b92ded513d72d.json"}}, {"family": "Nagrani", "given": "Rajini", "initials": "R", "orcid": "0000-0002-1708-2319", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef6c842faa8743c5912026afa0d8ebde.json"}}, {"family": "Nilsonne", "given": "Gustav", "initials": "G", "orcid": "0000-0001-5273-0150", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6211be5fc4ce4a63bddae08e6d336f15.json"}}, {"family": "Parker", "given": "Simon", "initials": "S"}, {"family": "Pickering", "given": "Brian", "initials": "B", "orcid": "0000-0002-6815-2938", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ca8df52b7cba413ebab9e6ca55c7d0e2.json"}}, {"family": "Pienta", "given": "Amy", "initials": "A"}, {"family": "Polydoratou", "given": "Panayiota", "initials": "P", "orcid": "0000-0002-7551-8002", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c6bf54582da40eb880813105e82f96b.json"}}, {"family": "Psomopoulos", "given": "Fotis", "initials": "F", "orcid": "0000-0002-0222-4273", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24743c9924274f449cbebde9c84ccebe.json"}}, {"family": "Rennes", "given": "Stephanie", "initials": "S", "orcid": "0000-0003-1458-7773", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e9c29b5851d4825b59c8c63ac241cbf.json"}}, {"family": "Rowe", "given": "Robyn", "initials": "R", "orcid": "0000-0003-0591-6213", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2cf7aefe4a5c4ceebc2290f40bc0c52f.json"}}, {"family": "Sansone", "given": "Susanna Assunta", "initials": "SA", "orcid": "0000-0001-5306-5690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3989d62ae34542fdbf5840a81957d964.json"}}, {"family": "Shanahan", "given": "Hugh", "initials": "H", "orcid": "0000-0003-1374-6015", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bab1d81eff584e68aaa469009875060c.json"}}, {"family": "Sitz", "given": "Lina", "initials": "L", "orcid": "0000-0002-6333-4986", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8beab9cc751647a6bb33e1ac5764eff8.json"}}, {"family": "Stocks", "given": "Joanne", "initials": "J", "orcid": "0000-0002-7800-6002", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8a546486dd840038ccd2c6f788f0ab9.json"}}, {"family": "Tovani-Palone", "given": "Marcos Roberto", "initials": "MR"}, {"family": "Uhlmansiek", "given": "Mary", "initials": "M", "orcid": "0000-0002-7949-2057", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9cc1455ca3f84309aac4f635c863b1ff.json"}}, {"family": null, "given": "", "initials": ""}], "type": "journal-article", "published": "2021-05-26", "journal": {"title": "Wellcome Open Res", "issn": "2398-502X", "volume": "5", "pages": "267", "issn-l": null}, "abstract": "The systemic challenges of the COVID-19 pandemic require cross-disciplinary collaboration in a global and timely fashion. Such collaboration needs open research practices and the sharing of research outputs, such as data and code, thereby facilitating research and research reproducibility and timely collaboration beyond borders. The Research Data Alliance COVID-19 Working Group recently published a set of recommendations and guidelines on data sharing and related best practices for COVID-19 research. These guidelines include recommendations for clinicians, researchers, policy- and decision-makers, funders, publishers, public health experts, disaster preparedness and response experts, infrastructure providers from the perspective of different domains (Clinical Medicine, Omics, Epidemiology, Social Sciences, Community Participation, Indigenous Peoples, Research Software, Legal and Ethical Considerations), and other potential users. These guidelines include recommendations for researchers, policymakers, funders, publishers and infrastructure providers from the perspective of different domains (Clinical Medicine, Omics, Epidemiology, Social Sciences, Community Participation, Indigenous Peoples, Research Software, Legal and Ethical Considerations). Several overarching themes have emerged from this document such as the need to balance the creation of data adherent to FAIR principles (findable, accessible, interoperable and reusable), with the need for quick data release; the use of trustworthy research data repositories; the use of well-annotated data with meaningful metadata; and practices of documenting methods and software. The resulting document marks an unprecedented cross-disciplinary, cross-sectoral, and cross-jurisdictional effort authored by over 160 experts from around the globe. This letter summarises key points of the Recommendations and Guidelines, highlights the relevant findings, shines a spotlight on the process, and suggests how these developments can be leveraged by the wider scientific community.", "doi": "10.12688/wellcomeopenres.16378.2", "pmid": "33501381", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7808050.2"}], "notes": [], "created": "2021-06-11T05:08:48.036Z", "modified": "2021-06-11T05:10:26.069Z"}, {"entity": "publication", "iuid": "1ee3f6241f5342e398bfae010ed8574f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ee3f6241f5342e398bfae010ed8574f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ee3f6241f5342e398bfae010ed8574f"}}, "title": "Diagnostic Potential of a Luminex-Based Coronavirus Disease 2019 Suspension Immunoassay (COVID-19 SIA) for the Detection of Antibodies against SARS-CoV-2.", "authors": [{"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Kolstad", "given": "Linda", "initials": "L"}, {"family": "Lindahl", "given": "Johanna F", "initials": "JF"}, {"family": "Albinsson", "given": "Bo", "initials": "B"}, {"family": "Bergqvist", "given": "Anders", "initials": "A"}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "journal article", "published": "2021-05-26", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "13", "issue": "6", "pages": null}, "abstract": "Due to the current, rapidly increasing Coronavirus disease 2019 (COVID-19) pandemic, efficient and highly specific diagnostic methods are needed. The receptor-binding part of the spike (S) protein, S1, has been suggested to be highly virus-specific; it does not cross-react with antibodies against other coronaviruses. Three recombinant partial S proteins of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) expressed in mammalian or baculovirus-insect cells were evaluated as antigens in a Luminex-based suspension immunoassay (SIA). The best performing antigen (S1; amino acids 16-685) was selected and further evaluated by serum samples from 76 Swedish patients or convalescents with COVID-19 (previously PCR and/or serologically confirmed), 200 pre-COVID-19 individuals (180 blood donors and 20 infants), and 10 patients with acute Epstein-Barr virus infection. All 76 positive samples showed detectable antibodies to S1, while none of the 210 negative controls gave a false positive antibody reaction. We further compared the COVID-19 SIA with a commercially available enzyme immunoassay and a previously evaluated COVID-19 rapid antibody test. The results revealed an overall assay sensitivity of 100%, a specificity of 100% for both IgM and IgG, a quantitative ability at concentrations up to 25 BAU/mL, and a better performance as compared to the commercial assays, suggesting the COVID-19 SIA as a most valuable tool for efficient laboratory-based serology.", "doi": "10.3390/v13060993", "pmid": "34073484", "labels": {"Category: Other": null, "Type: Journal article": null, "Funder: H2020": null, "Funder: VR": null, "Category: Biochemistry": null, "Research Area: High-throughput and high-content serology": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "v13060993"}], "notes": [], "created": "2021-06-04T11:11:07.153Z", "modified": "2021-08-25T08:17:08.764Z"}, {"entity": "publication", "iuid": "9e8e9c1414cb4a1d8985ebb84f523153", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9e8e9c1414cb4a1d8985ebb84f523153.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9e8e9c1414cb4a1d8985ebb84f523153"}}, "title": "Depression, anxiety and stress among Swedish university students before and during six months of the COVID-19 pandemic: A cohort study.", "authors": [{"family": "Johansson", "given": "Fred", "initials": "F"}, {"family": "C\u00f4t\u00e9", "given": "Pierre", "initials": "P"}, {"family": "Hogg-Johnson", "given": "Sheilah", "initials": "S"}, {"family": "Rudman", "given": "Ann", "initials": "A"}, {"family": "Holm", "given": "Lena W", "initials": "LW"}, {"family": "Grotle", "given": "Margreth", "initials": "M"}, {"family": "Jensen", "given": "Irene", "initials": "I"}, {"family": "Sundberg", "given": "Tobias", "initials": "T"}, {"family": "Edlund", "given": "Klara", "initials": "K"}, {"family": "Skillgate", "given": "Eva", "initials": "E"}], "type": "journal article", "published": "2021-05-26", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": null, "issue": null, "pages": "14034948211015814"}, "abstract": "The COVID-19 pandemic has had a profound effect on societies and citizens worldwide, raising concerns about potential mental health impacts. We aimed to describe trajectories of depression, anxiety and stress symptoms during the COVID-19 outbreak compared to before the outbreak, and to determine if trajectories were modified by pre-pandemic loneliness, poor sleep quality and mental health problems.\r\n\r\nWe conducted a cohort study with 1836 Swedish university students entering the study before 13 March 2020, the onset of the pandemic, with follow-ups within three (FU1) and six months (FU2) of the outbreak. Generalized Estimating Equations were used to estimate mean differences in symptom levels over time-periods, and to estimate potential effect modifications.\r\n\r\nWe found small differences in mean levels of the depression, anxiety and stress scale (DASS-21) over time. Compared to before the pandemic, depression increased by 0.25 points of 21 (95% CI: 0.04 to -0.45) at FU1 and decreased by 0.75/21 (95% CI:-0.97 to -0.53) at FU2. Anxiety decreased from baseline to FU1 by 0.09/21 (95% CI: -0.24 to -0.07) and by 0.77/21 (95% CI: -0.93 to -0.61) to FU2. Stress decreased from baseline to FU1 by 0.30/21 (95% CI: -0.52 to -0.09) and by 1.32/21 (95% CI: -1.55 to -1.09) to FU2. Students with pre-pandemic loneliness, poor sleep quality or pre-pandemic mental health problems did not have worse trajectories of mean mental health symptoms.\r\n\r\nSymptom levels were relatively stable during the first three months of the pandemic, while there was a slight decrease during the summer months, probably due to seasonality effects.", "doi": "10.1177/14034948211015814", "pmid": "34034577", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-05-29T15:40:53.363Z", "modified": "2021-07-14T09:04:52.922Z"}, {"entity": "publication", "iuid": "ab5e1324aa344ff6a675dd4c0b159a2f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ab5e1324aa344ff6a675dd4c0b159a2f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ab5e1324aa344ff6a675dd4c0b159a2f"}}, "title": "Multiplexed detection of SARS-CoV-2 and other respiratory infections in high throughput by SARSeq.", "authors": [{"family": "Yelagandula", "given": "Ramesh", "initials": "R"}, {"family": "Bykov", "given": "Aleksandr", "initials": "A"}, {"family": "Vogt", "given": "Alexander", "initials": "A"}, {"family": "Heinen", "given": "Robert", "initials": "R"}, {"family": "\u00d6zkan", "given": "Ezgi", "initials": "E"}, {"family": "Strobl", "given": "Marcus Martin", "initials": "MM"}, {"family": "Baar", "given": "Juliane Christina", "initials": "JC"}, {"family": "Uzunova", "given": "Kristina", "initials": "K"}, {"family": "Hajdusits", "given": "Bence", "initials": "B"}, {"family": "Kordic", "given": "Darja", "initials": "D"}, {"family": "Suljic", "given": "Erna", "initials": "E"}, {"family": "Kurtovic-Kozaric", "given": "Amina", "initials": "A"}, {"family": "Izetbegovic", "given": "Sebija", "initials": "S"}, {"family": "Schaeffer", "given": "Justine", "initials": "J"}, {"family": "Hufnagl", "given": "Peter", "initials": "P"}, {"family": "Zoufaly", "given": "Alexander", "initials": "A"}, {"family": "Seitz", "given": "Tamara", "initials": "T"}, {"family": "VCDI", "given": "", "initials": ""}, {"family": "F\u00f6dinger", "given": "Manuela", "initials": "M"}, {"family": "Allerberger", "given": "Franz", "initials": "F"}, {"family": "Stark", "given": "Alexander", "initials": "A"}, {"family": "Cochella", "given": "Luisa", "initials": "L"}, {"family": "Elling", "given": "Ulrich", "initials": "U"}], "type": "journal article", "published": "2021-05-25", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "3132", "issn-l": "2041-1723"}, "abstract": "The COVID-19 pandemic has demonstrated the need for massively-parallel, cost-effective tests monitoring viral spread. Here we present SARSeq, saliva analysis by RNA sequencing, a method to detect SARS-CoV-2 and other respiratory viruses on tens of thousands of samples in parallel. SARSeq relies on next generation sequencing of multiple amplicons generated in a multiplexed RT-PCR reaction. Two-dimensional, unique dual indexing, using four indices per sample, enables unambiguous and scalable assignment of reads to individual samples. We calibrate SARSeq on SARS-CoV-2 synthetic RNA, virions, and hundreds of human samples of various types. Robustness and sensitivity were virtually identical to quantitative RT-PCR. Double-blinded benchmarking to gold standard quantitative-RT-PCR performed by human diagnostics laboratories confirms this high sensitivity. SARSeq can be used to detect Influenza A and B viruses and human rhinovirus in parallel, and can be expanded for detection of other pathogens. Thus, SARSeq is ideally suited for differential diagnostic of infections during a pandemic.", "doi": "10.1038/s41467-021-22664-5", "pmid": "34035246", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-22664-5"}, {"db": "GEO", "key": "GSE163688", "description": "Sequencing data for all experiments"}, {"db": "URL", "key": "https://www.nature.com/articles/s41467-021-22664-5#MOESM5", "description": "Primer sequences"}], "notes": [], "created": "2021-05-29T15:34:33.669Z", "modified": "2021-11-18T13:05:10.873Z"}, {"entity": "publication", "iuid": "e892756c8c4a415f812888a2f2db458a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e892756c8c4a415f812888a2f2db458a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e892756c8c4a415f812888a2f2db458a"}}, "title": "Impact of lockdown and school closure on children's health and well-being during the first wave of COVID-19: a narrative review.", "authors": [{"family": "Rajmil", "given": "Luis", "initials": "L", "orcid": "0000-0002-6625-0649", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96b681441723437abfbe49c7af90af6f.json"}}, {"family": "Hjern", "given": "Anders", "initials": "A"}, {"family": "Boran", "given": "Perran", "initials": "P"}, {"family": "Gunnlaugsson", "given": "Geir", "initials": "G"}, {"family": "Kraus de Camargo", "given": "Olaf", "initials": "O"}, {"family": "Raman", "given": "Shanti", "initials": "S", "orcid": "0000-0002-4546-3231", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8dddb7bcfae9429b864a3ff7cbc06c45.json"}}, {"family": "International Society for Social Pediatrics & Child Health (ISSOP) and International Network for Research on Inequalities in Child Health (INRICH) COVID-19 Working Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-25", "journal": {"title": "BMJ Paediatr Open", "issn": "2399-9772", "issn-l": null, "volume": "5", "issue": "1", "pages": "e001043"}, "abstract": "In the context of containment measures against the COVID-19 pandemic, the aims were to examine the impact of lockdown and school closures on childs' and adolescents' health and well-being and social inequalities in health.\r\n\r\nLiterature review by searching five databases until November 2020. We included quantitative peer-reviewed studies reporting health and well-being outcomes in children (0-18 years) related to closure measures' impact due to COVID-19. A pair of authors assessed the risk of bias of included studies. A descriptive and narrative synthesis was carried out.\r\n\r\nTwenty-two studies, including high-income, middle-income and low-income countries, fulfilled our search criteria and were judged not to have an increased risk of bias. Studies from Australia, Spain and China showed an increase in depressive symptoms and decrease in life satisfaction. A decrease in physical activity and increase in unhealthy food consumption were shown in studies from two countries. There was a decrease in the number of visits to the emergency department in four countries, an increase in child mortality in Cameroon and a decrease by over 50% of immunisations administered in Pakistan. A significant drop of 39% in child protection medical examination referrals during 2020 compared with the previous years was found in the UK, a decrease in allegations of child abuse and neglect by almost one-third due to school closures in Florida, and an increase in the number of children with physical child abuse trauma was found in one centre in the USA.\r\n\r\nFrom available reports, pandemic school closure and lockdown have adverse effects on child health and well-being in the short and probably long term. We urge governments to take the negative public health consequences into account before adopting restrictive measures in childhood.", "doi": "10.1136/bmjpo-2021-001043", "pmid": "34192198", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "bmjpo-2021-001043"}, {"db": "pmc", "key": "PMC8154298"}], "notes": [], "created": "2021-07-05T14:26:37.785Z", "modified": "2022-11-23T09:00:53.996Z"}, {"entity": "publication", "iuid": "e50e510d5bf7459e8e856f436a0df30d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e50e510d5bf7459e8e856f436a0df30d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e50e510d5bf7459e8e856f436a0df30d"}}, "title": "Expanding Utilization of Home Dialysis: An Action Agenda From the First International Home Dialysis Roundtable.", "authors": [{"family": "Mendu", "given": "Mallika L", "initials": "ML"}, {"family": "Divino-Filho", "given": "Jos\u00e9 Carolino", "initials": "JC"}, {"family": "Vanholder", "given": "Raymond", "initials": "R"}, {"family": "Mitra", "given": "Sandip", "initials": "S"}, {"family": "Davies", "given": "Simon J", "initials": "SJ"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Damron", "given": "Kelli Collins", "initials": "KC"}, {"family": "Gallego", "given": "Daniel", "initials": "D"}, {"family": "Seger", "given": "Michelle", "initials": "M"}, {"family": "International Home Dialysis Roundtable Steering Committee", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-25", "journal": {"title": "Kidney Med", "issn": "2590-0595", "volume": "3", "issue": "4", "pages": "635-643", "issn-l": null}, "abstract": "In a groundbreaking meeting, leading global kidney disease organizations came together in the fall of 2020 as an International Home Dialysis Roundtable (IHDR) to address strategies to increase access to and uptake of home dialysis, both peritoneal dialysis and home hemodialysis. This challenge has become urgent in the wake of the coronavirus disease 2019 (COVID-19) pandemic, during which patients with advanced kidney disease, who are more susceptible to viral infections and severe complications, must be able to safely physically distance at home. To boost access to home dialysis on a global scale, IHDR members committed to collaborate, through the COVID-19 public health emergency and beyond, to promote uptake of home dialysis on a broad scale. Their commitments included increasing the reach and influence of key stakeholders with policy makers, building a cooperative of advocates and champions for home dialysis, working together to increase patient engagement and empowerment, and sharing intelligence about policy, education, and other programs so that such efforts can be operationalized globally. In the spirit of international cooperation, IHDR members agreed to document, amplify, and replicate established efforts shown to improve access to home dialysis and support new policies that facilitate access through procedures, innovation, and reimbursement.", "doi": "10.1016/j.xkme.2021.04.004", "pmid": "34401729", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2590-0595(21)00100-X"}, {"db": "pmc", "key": "PMC8350829"}], "notes": [], "created": "2021-08-20T12:16:17.141Z", "modified": "2021-08-20T12:16:31.443Z"}, {"entity": "publication", "iuid": "07a32c0bc5e24434929d4ce6ae95b614", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07a32c0bc5e24434929d4ce6ae95b614.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07a32c0bc5e24434929d4ce6ae95b614"}}, "title": "COVID-19 and the selection problem in national cause-of-death statistics.", "authors": [{"family": "Lindahl", "given": "B I B", "initials": "BIB"}], "type": "journal article", "published": "2021-05-25", "journal": {"title": "Hist Philos Life Sci", "issn": "1742-6316", "volume": "43", "issue": "2", "pages": "72", "issn-l": null}, "abstract": "The World Health Organization has issued international instructions for certification and classification (coding) of the coronavirus disease (COVID-19) as cause of death. Central to these instructions is the selection of the underlying cause of death for a public health preventive purpose. This article focuses on two rules for this selection: (1) that a death due to COVID-19 should be counted independently of pre-existing conditions that are suspected of triggering a severe course of COVID-19 and (2) that COVID-19 should not be considered as due to anything else. The article argues that observance of the first rule may not always lead to an optimal selection from a preventive point of view and that in the future the ascertainment of an animal source of the coronavirus (SARS-CoV-2) would make it possible to reconceptualize 'COVID-19' and create a zoonotic classification code by means of which a factor of a greater preventive value could be selected than what is currently possible.", "doi": "10.1007/s40656-021-00420-8", "pmid": "34036448", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40656-021-00420-8"}], "notes": [], "created": "2021-05-29T15:33:59.474Z", "modified": "2021-05-29T15:33:59.496Z"}, {"entity": "publication", "iuid": "677b5b6503734ac8907936442131505a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/677b5b6503734ac8907936442131505a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/677b5b6503734ac8907936442131505a"}}, "title": "Urinary cytokines correlate with acute kidney injury in critically ill COVID-19 patients.", "authors": [{"family": "Gradin", "given": "A", "initials": "A"}, {"family": "Andersson", "given": "H", "initials": "H"}, {"family": "Luther", "given": "T", "initials": "T"}, {"family": "Anderberg", "given": "S B\u00fclow", "initials": "SB"}, {"family": "Rubertsson", "given": "S", "initials": "S"}, {"family": "Lipcsey", "given": "M", "initials": "M"}, {"family": "\u00c5berg", "given": "M", "initials": "M"}, {"family": "Larsson", "given": "A", "initials": "A"}, {"family": "Frithiof", "given": "R", "initials": "R"}, {"family": "Hultstr\u00f6m", "given": "M", "initials": "M"}], "type": "journal article", "published": "2021-05-24", "journal": {"title": "Cytokine", "issn": "1043-4666", "issn-l": null, "volume": "146", "issue": null, "pages": "155589"}, "abstract": "Acute kidney injury is common in COVID-19 patients admitted to the ICU. Urinary biomarkers are a non-invasive way of assaying renal damage, and so far, urinary cytokines are not fully investigated. The current study aimed to assess urinary cytokine levels in COVID-19 patients.\r\n\r\nUrine was collected from COVID-19 patients (n = 29) in intensive care and compared to a preoperative group of patients (n = 9) with no critical illness. 92 urinary cytokines were analyzed in multiplex using the Olink Target 96 inflammation panel and compared to clinical characteristics, and urinary markers of kidney injury.\r\n\r\nThere were strong correlations between proinflammatory cytokines and between urinary cytokines and urinary kidney injury markers in 29 COVID-19 patients. Several cytokines were correlated to kidney injury, 31 cytokines to AKI stage and 19 cytokines correlated to maximal creatinine.\r\n\r\nUrinary inflammatory cytokines from a wide range of immune cell lineages were significantly upregulated during COVID-19 and the upregulation correlated with acute kidney injury as well as urinary markers of kidney tissue damage.", "doi": "10.1016/j.cyto.2021.155589", "pmid": "34161857", "labels": {"Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pii", "key": "S1043-4666(21)00172-1"}, {"db": "pmc", "key": "PMC8141692"}], "notes": [], "created": "2021-06-21T05:38:51.889Z", "modified": "2021-06-28T17:55:27.612Z"}, {"entity": "publication", "iuid": "fcc09b1d9efd444aae55abf8ed8b4e78", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fcc09b1d9efd444aae55abf8ed8b4e78.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fcc09b1d9efd444aae55abf8ed8b4e78"}}, "title": "Multiple sclerosis and COVID-19: The Swedish experience.", "authors": [{"family": "Landtblom", "given": "Anne-Marie", "initials": "AM"}, {"family": "Berntsson", "given": "Shala G", "initials": "SG"}, {"family": "Bostr\u00f6m", "given": "Inger", "initials": "I"}, {"family": "Iacobaeus", "given": "Ellen", "initials": "E"}], "type": "journal article", "published": "2021-05-24", "journal": {"title": "Acta Neurol Scand", "issn": "1600-0404", "volume": null, "issue": null, "issn-l": null}, "abstract": "The COVID-19 pandemic has brought challenges for healthcare management of patients with multiple sclerosis (MS). Concerns regarding vulnerability to infections and disease-modifying therapies (DMTs) and their complications have been raised. Recent published guidelines on the use of DMTs in relation to COVID-19 in MS patients have been diverse between countries with lack of evidence-based facts. In Sweden, there exists a particular interest in anti-CD20 therapy as a possible risk factor for severe COVID-19 due to the large number of rituximab-treated patients off-label in the country. Rapid responses from the Swedish MS Association (SMSS) and the Swedish MS registry (SMSreg) have resulted in national guidelines on DMT use for MS patients and implementation of a COVID-19 module in the SMSreg. Recently updated guidelines also included recommendations on COVID-19 vaccination with regard to the different DMTs. Social distancing policies forced implementation of telemedicine consultation to replace in-person consultations as part of regular MS health care. Patient-reported outcome measures (PROMs) in SMSreg have been useful in this respect. This paper reports our experiences on the progress of national MS health care during the COVID-19 pandemic, in addition to offering an overview of the present scientific context.", "doi": "10.1111/ane.13453", "pmid": "34028810", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-29T16:22:09.622Z", "modified": "2021-05-29T16:22:09.644Z"}, {"entity": "publication", "iuid": "45dbb9d073a14f418457c5550eb25254", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/45dbb9d073a14f418457c5550eb25254.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/45dbb9d073a14f418457c5550eb25254"}}, "title": "Hospital admission and mortality rates for non-covid diseases in Denmark during covid-19 pandemic: nationwide population based cohort study.", "authors": [{"family": "Bodilsen", "given": "Jacob", "initials": "J"}, {"family": "Nielsen", "given": "Peter Br\u00f8nnum", "initials": "PB"}, {"family": "S\u00f8gaard", "given": "Mette", "initials": "M"}, {"family": "Dalager-Pedersen", "given": "Michael", "initials": "M"}, {"family": "Speiser", "given": "Lasse Ole Zacho", "initials": "LOZ"}, {"family": "Yndigegn", "given": "Troels", "initials": "T"}, {"family": "Nielsen", "given": "Henrik", "initials": "H"}, {"family": "Larsen", "given": "Torben Bjerregaard", "initials": "TB"}, {"family": "Skj\u00f8th", "given": "Flemming", "initials": "F"}], "type": "journal article", "published": "2021-05-24", "journal": {"title": "BMJ", "issn": "1756-1833", "issn-l": null, "volume": "373", "issue": null, "pages": "n1135"}, "abstract": "To determine the incidence of hospital admissions and associated mortality rates for non-covid medical conditions during the covid-19 pandemic.\r\n\r\nNationwide, population based cohort study.\r\n\r\nDenmark from 13 March 2019 to 27 January 2021.\r\n\r\nAll Danish residents >1 year of age.\r\n\r\nPopulation based healthcare registries that encompass the entire Danish population were used to compare hospital admission and mortality rates during the covid-19 pandemic (from 11 March 2020 to 27 January 2021) with the prepandemic baseline data (from 13 March 2019 to 10 March 2020). Hospital admissions were categorised as covid-19 when patients were assigned a diagnosis code for covid-19 within five days of admission. All patients were followed until migration, death, or end of follow-up, whichever came first. Rate ratios for hospital admissions were computed using Poisson regression and were directly standardised using the Danish population on 1 January 2019 as reference. 30 day mortality rate ratios were examined by Cox regression, adjusted for age and sex, and covid-19 diagnosis was used as a competing risk.\r\n\r\n5 753 179 residents were identified during 567.8 million person weeks of observation, with 1 113 705 hospital admissions among 675 447 people. Compared with the prepandemic baseline period (mean hospital admission rate 204.1 per 100 000/week), the overall hospital admission rate for non-covid-19 conditions decreased to 142.8 per 100 000/week (rate ratio 0.70, 95% confidence interval 0.66 to 0.74) after the first national lockdown, followed by a gradual return to baseline levels until the second national lockdown when it decreased to 158.3 per 100 000/week (0.78, 0.73 to 0.82). This pattern was mirrored for most major diagnosis groups except for non-covid-19 respiratory diseases, nervous system diseases, cancer, heart failure, sepsis, and non-covid-19 respiratory infections, which remained lower throughout the study period. Overall 30 day mortality rates were higher during the first national lockdown (mortality rate ratio 1.28, 95% confidence interval 1.23 to 1.32) and the second national lockdown (1.20, 1.16 to 1.24), and these results were similar across most major diagnosis groups. For non-covid-19 respiratory diseases, cancer, pneumonia, and sepsis, the 30 day mortality rate ratios were also higher between lockdown periods.\r\n\r\nHospital admissions for all major non-covid-19 disease groups decreased during national lockdowns compared with the prepandemic baseline period. Additionally, mortality rates were higher overall and for patients admitted to hospital with conditions such as respiratory diseases, cancer, pneumonia, and sepsis. Increased attention towards management of serious non-covid-19 medical conditions is warranted.", "doi": "10.1136/bmj.n1135", "pmid": "34035000", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8142604"}], "notes": [], "created": "2021-05-29T15:40:08.762Z", "modified": "2021-07-14T09:02:41.329Z"}, {"entity": "publication", "iuid": "554af6363be444beb60516c49149884f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/554af6363be444beb60516c49149884f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/554af6363be444beb60516c49149884f"}}, "title": "Hematopoietic stem cell transplantation for autoimmune diseases in the time of COVID-19: EBMT guidelines and recommendations.", "authors": [{"family": "Greco", "given": "Raffaella", "initials": "R"}, {"family": "Alexander", "given": "Tobias", "initials": "T"}, {"family": "Burman", "given": "Joachim", "initials": "J"}, {"family": "Del Papa", "given": "Nicoletta", "initials": "N"}, {"family": "de Vries-Bouwstra", "given": "Jeska", "initials": "J"}, {"family": "Farge", "given": "Dominique", "initials": "D"}, {"family": "Henes", "given": "J\u00f6rg", "initials": "J"}, {"family": "Kazmi", "given": "Majid", "initials": "M"}, {"family": "Kirgizov", "given": "Kirill", "initials": "K"}, {"family": "Muraro", "given": "Paolo A", "initials": "PA"}, {"family": "Ricart", "given": "Elena", "initials": "E"}, {"family": "Rovira", "given": "Montserrat", "initials": "M"}, {"family": "Saccardi", "given": "Riccardo", "initials": "R"}, {"family": "Sharrack", "given": "Basil", "initials": "B"}, {"family": "Snarski", "given": "Emilian", "initials": "E"}, {"family": "Withers", "given": "Barbara", "initials": "B"}, {"family": "Jessop", "given": "Helen", "initials": "H"}, {"family": "Boglione", "given": "Claudia", "initials": "C"}, {"family": "Kramer", "given": "Ellen", "initials": "E"}, {"family": "Badoglio", "given": "Manuela", "initials": "M"}, {"family": "Labopin", "given": "Myriam", "initials": "M"}, {"family": "Orchard", "given": "Kim", "initials": "K"}, {"family": "Corbacioglu", "given": "Selim", "initials": "S"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Mikulska", "given": "Malgorzata", "initials": "M"}, {"family": "De la Camara", "given": "Rafael", "initials": "R"}, {"family": "Snowden", "given": "John A", "initials": "JA"}, {"family": "European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP), Infectious Diseases Working Party (IDWP), Pediatric Working Party (PWP), Joint Accreditation Committee of the International Society for Cellular Therapy (ISCT) and EBMT (JACIE), EBMT Nurses Group and Patient Advocacy Committee", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-24", "journal": {"title": "Bone Marrow Transplant", "issn": "1476-5365", "volume": null, "issue": null, "issn-l": "0268-3369"}, "abstract": "Coronavirus disease-19 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), represents one of the biggest challenges of 21st century, threatening public health around the globe. Increasing age and presence of co-morbidities are reported risk factors for severe disease and mortality, along with autoimmune diseases (ADs) and immunosuppressive treatments such as haematopoietic stem cell transplantation (HSCT), which are also associated with adverse outcomes. We review the impact of the pandemic on specific groups of patients with neurological, rheumatological, and gastroenterological indications, along with the challenges delivering HSCT in adult and pediatric populations. Moving forward, we developed consensus-based guidelines and recommendations for best practice and quality of patient care in order to support clinicians, scientists, and their multidisciplinary teams, as well as patients and their carers. These guidelines aim to support national and international organizations related to autoimmune diseases and local clinical teams delivering HSCT. Areas of unmet need and future research questions are also highlighted. The waves of the COVID-19 pandemic are predicted to be followed by an \"endemic\" phase and therefore an ongoing risk within a \"new normality\". These recommendations reflect currently available evidence, coupled with expert opinion, and will be revised according to necessary modifications in practice.", "doi": "10.1038/s41409-021-01326-6", "pmid": "34031556", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41409-021-01326-6"}, {"db": "pmc", "key": "PMC8143059"}], "notes": [], "created": "2021-05-29T15:41:52.441Z", "modified": "2021-05-29T15:41:52.450Z"}, {"entity": "publication", "iuid": "f9c19d1a5be34893afa3f5aba87ffb50", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f9c19d1a5be34893afa3f5aba87ffb50.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f9c19d1a5be34893afa3f5aba87ffb50"}}, "title": "Health care workers and migrant health: Pre- and post-COVID-19 considerations for reviewing and expanding the research agenda.", "authors": [{"family": "Gunn", "given": "Virginia", "initials": "V"}, {"family": "Somani", "given": "Rozina", "initials": "R"}, {"family": "Muntaner", "given": "Carles", "initials": "C"}], "type": "journal article", "published": "2021-05-24", "journal": {"title": "J Migr Health", "issn": "2666-6235", "volume": "4", "pages": "100048", "issn-l": null}, "abstract": "The main purpose of this article is to review several ways in which health care workers could either impact migrant health or be directly impacted by migration and, based on this, suggest the expansion of the current research agenda on migration and health to address a range of topics that are currently either neglected, insufficiently researched, or researched from different perspectives. To ground this suggestion and emphasize the complexity and significance of migrant health research, we start by briefly reviewing several migration-related notions including the process of migration and its key facilitators and benefits; existing barriers to the provision of migrant health care; and the intricate links between health systems, health professionals, and migrant health. The three areas of research examined in this article address (i) the specific role of health workers in providing care to migrants and refugees and their capacity to do so, (ii) the health problems experienced by health workers who become migrants or refugees, and (iii) the precarious employment conditions experienced by both migrant and non-migrant health care workers. After summarizing the current available evidence on these topics, we discuss key information gaps and strategies to address them, while also incorporating several relevant COVID-19 pandemic considerations and research implications. Expanding the focus of research studies on migration and health could not only enhance the results of current strategies by supplying additional information to support their implementation but also spearhead the development of new solutions to the migrant health problem.", "doi": "10.1016/j.jmh.2021.100048", "pmid": "34405193", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-6235(21)00015-5"}, {"db": "pmc", "key": "PMC8352207"}], "notes": [], "created": "2021-08-20T12:23:05.840Z", "modified": "2021-08-20T12:23:05.852Z"}, {"entity": "publication", "iuid": "cc8277510ec6494b9a70d5e7a955867b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc8277510ec6494b9a70d5e7a955867b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc8277510ec6494b9a70d5e7a955867b"}}, "title": "Challenges in PhD education due to COVID-19 - disrupted supervision or business as usual: a cross-sectional survey of Swedish biomedical sciences graduate students.", "authors": [{"family": "B\u00f6rgeson", "given": "Emma", "initials": "E"}, {"family": "Sotak", "given": "Matus", "initials": "M"}, {"family": "Kraft", "given": "Jamie", "initials": "J"}, {"family": "Bagunu", "given": "Grace", "initials": "G"}, {"family": "Bi\u00f6rserud", "given": "Christina", "initials": "C"}, {"family": "Lange", "given": "Stephan", "initials": "S"}], "type": "journal article", "published": "2021-05-22", "journal": {"title": "BMC Med Educ", "issn": "1472-6920", "volume": "21", "issue": "1", "pages": "294", "issn-l": null}, "abstract": "It remains unclear to what extent the SARS-CoV-2/COVID-19 pandemic disrupted the normal progression of biomedical and medical science graduate programs and if there was a lasting impact on the quality and quantity of supervision of PhD-students. To date, multiple editorials and commentaries indicate the severity of the disruption without providing sufficient evidence with quantifiable data.\n\nAn online survey was submitted to the administrative offices of biomedical and medical PhD-programs at eight major universities in Sweden to gauge the impact of the pandemic on the students. It consisted of multiple-choice and open-ended questions where students could provide examples of positive and/or negative supervision strategies. Open answered questions were coded as either examples of positive or negative support.\n\nPhD students were divided into two groups: those with improved or unchanged supervision during the pandemic (group 1, n = 185), versus those whose supervision worsened (group 2, n = 69). Group 1 received more help from supervisors and more frequent supervision via both online and alternative platforms (email/messages and telephone). There was no significant difference in educational-stage, gender or caretaking responsibilities between the groups.\n\nIt is important for the scientific community to learn how to provide the best possible supervision for PhD students during the pandemic. Our data suggests that more frequent supervision, and using a diverse array of meeting platforms is helpful. In addition, it is important for the students to feel that they have their supervisor's emotional support. Several students also expressed that they would benefit from an extension of their PhD programs due to delays caused by the pandemic.", "doi": "10.1186/s12909-021-02727-3", "pmid": "34022871", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12909-021-02727-3"}, {"db": "pmc", "key": "PMC8140581"}], "notes": [], "created": "2021-05-29T16:23:39.100Z", "modified": "2021-05-29T16:23:39.112Z"}, {"entity": "publication", "iuid": "56750c28d65e4a0c9e2f792150d25e4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56750c28d65e4a0c9e2f792150d25e4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56750c28d65e4a0c9e2f792150d25e4c"}}, "title": "Long term extracorporeal membrane oxygenation bridge to lung transplant after COVID-19.", "authors": [{"family": "Magnusson", "given": "Jesper M", "initials": "JM"}, {"family": "Silverborn", "given": "Martin", "initials": "M"}, {"family": "Broome", "given": "Michael", "initials": "M"}, {"family": "Riise", "given": "Gerdt C", "initials": "GC"}, {"family": "Dellgren", "given": "G\u00f6ran", "initials": "G"}], "type": "case reports", "published": "2021-05-21", "journal": {"title": "Ann Thorac Surg", "issn": "1552-6259", "volume": null, "issue": null, "issn-l": null}, "abstract": "We report a patient with acute respiratory syndrome coronavirus 2 infection and irreversible lung destruction who underwent successful lung transplantation after 138 days of bridging with extracorporeal membrane oxygenation support. The case exemplifies that lung transplantation might be a possibility after very long-term Coronavirus disease 2019 care, even if the patient is initially unsuitable. Patient consent was acquired before writing the case report.", "doi": "10.1016/j.athoracsur.2021.04.092", "pmid": "34029534", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0003-4975(21)00887-0"}, {"db": "pmc", "key": "PMC8139362"}], "notes": [], "created": "2021-05-29T16:20:44.248Z", "modified": "2021-05-29T16:20:59.683Z"}, {"entity": "publication", "iuid": "eb4ec86a74ce44358788f11c359b46b8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb4ec86a74ce44358788f11c359b46b8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb4ec86a74ce44358788f11c359b46b8"}}, "title": "Position statement of the international network for child and family centered care: Child and family centred care during the COVID19 pandemic.", "authors": [{"family": "Al-Motlaq", "given": "Mohammad", "initials": "M"}, {"family": "Neill", "given": "Sarah", "initials": "S"}, {"family": "Foster", "given": "Mandie Jane", "initials": "MJ"}, {"family": "Coyne", "given": "Imelda", "initials": "I"}, {"family": "Houghton", "given": "Davina", "initials": "D"}, {"family": "Angelhoff", "given": "Charlotte", "initials": "C"}, {"family": "Rising-Holmstr\u00f6m", "given": "Malin", "initials": "M"}, {"family": "Majamanda", "given": "Maureen", "initials": "M"}], "type": "journal article", "published": "2021-05-20", "journal": {"title": "J Pediatr Nurs", "issn": "1532-8449", "volume": "61", "issue": null, "pages": "140-143", "issn-l": null}, "abstract": "It is the position of the International Network for Child and Family Centered Care (INCFCC) that COVID19 restrictions pose tremendous challenges for the health care team in their efforts to provide child and family centered care (CFCC). COVID-19 restrictions impact on the family's right to be presernt with their ill child and to contribute to the caring process. A limited number of articles have discussed challenges about the successful delivery of CFCC during the COVID-19 pandemic. Based on current literature, the INCFCC stresses the need for continuous facilitation implementation of child and family centred care as, it is essential for children's physical and psychological wellbeing. Furthermore we believe that the families' presence and participation holds more benefits than risks to the health of children, their families, and the health care team.", "doi": "10.1016/j.pedn.2021.05.002", "pmid": "34052501", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0882-5963(21)00149-4"}], "notes": [], "created": "2021-05-31T16:10:04.873Z", "modified": "2021-05-31T16:10:04.890Z"}, {"entity": "publication", "iuid": "3b5d32446a3444ada161d4e85c38c33d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b5d32446a3444ada161d4e85c38c33d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b5d32446a3444ada161d4e85c38c33d"}}, "title": "Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice", "authors": [{"family": "De Gasparo", "given": "Raoul", "initials": "R"}, {"family": "Pedotti", "given": "Mattia", "initials": "M"}, {"family": "Simonelli", "given": "Luca", "initials": "L"}, {"family": "Nickl", "given": "Petr", "initials": "P", "orcid": "0000-0002-4289-0502", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd09e87cae524e40922a94720a978674.json"}}, {"family": "Muecksch", "given": "Frauke", "initials": "F", "orcid": "0000-0002-0132-5101", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94b175929ad14fec921e737bb3dceda7.json"}}, {"family": "Cassaniti", "given": "Irene", "initials": "I"}, {"family": "Percivalle", "given": "Elena", "initials": "E"}, {"family": "Lorenzi", "given": "Julio C C", "initials": "JCC"}, {"family": "Mazzola", "given": "Federica", "initials": "F"}, {"family": "Magr\u00ec", "given": "Davide", "initials": "D", "orcid": "0000-0003-3790-5332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15cedaba7cb3438fad6c71e2a015921e.json"}}, {"family": "Michalcikova", "given": "Tereza", "initials": "T"}, {"family": "Haviernik", "given": "Jan", "initials": "J"}, {"family": "Honig", "given": "Vaclav", "initials": "V", "orcid": "0000-0003-0469-4604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65499eafa5a24320b87d2534f4dcf99a.json"}}, {"family": "Mrazkova", "given": "Blanka", "initials": "B"}, {"family": "Polakova", "given": "Natalie", "initials": "N"}, {"family": "Fortova", "given": "Andrea", "initials": "A"}, {"family": "Tureckova", "given": "Jolana", "initials": "J"}, {"family": "Iatsiuk", "given": "Veronika", "initials": "V"}, {"family": "Di Girolamo", "given": "Salvatore", "initials": "S"}, {"family": "Palus", "given": "Martin", "initials": "M"}, {"family": "Zudova", "given": "Dagmar", "initials": "D"}, {"family": "Bednar", "given": "Petr", "initials": "P"}, {"family": "Bukova", "given": "Ivana", "initials": "I"}, {"family": "Bianchini", "given": "Filippo", "initials": "F"}, {"family": "Mehn", "given": "Dora", "initials": "D"}, {"family": "Nencka", "given": "Radim", "initials": "R"}, {"family": "Strakova", "given": "Petra", "initials": "P"}, {"family": "Pavlis", "given": "Oto", "initials": "O"}, {"family": "Rozman", "given": "Jan", "initials": "J", "orcid": "0000-0002-8035-8904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69dca82b58b8449c8af3e096813d6003.json"}}, {"family": "Gioria", "given": "Sabrina", "initials": "S"}, {"family": "Sammartino", "given": "Jos\u00e8 Camilla", "initials": "JC"}, {"family": "Giardina", "given": "Federica", "initials": "F"}, {"family": "Gaiarsa", "given": "Stefano", "initials": "S"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q", "orcid": "0000-0003-1990-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94a32366862b470eba3a15521b9be290.json"}}, {"family": "Barnes", "given": "Christopher O", "initials": "CO"}, {"family": "Bjorkman", "given": "Pamela J", "initials": "PJ", "orcid": "0000-0002-2277-3990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65549e18865046ac99cfee9f969c2759.json"}}, {"family": "Calzolai", "given": "Luigi", "initials": "L", "orcid": "0000-0002-8474-7974", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e3a67661994a48e28a8279fb27346285.json"}}, {"family": "Piralla", "given": "Antonio", "initials": "A", "orcid": "0000-0002-6062-2579", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af56fb1bc11f43d9861faa71c5b50043.json"}}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Nussenzweig", "given": "Michel C", "initials": "MC"}, {"family": "Bieniasz", "given": "Paul D", "initials": "PD", "orcid": "0000-0002-2368-3719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72f7075120214d4091202cd80ffbe506.json"}}, {"family": "Hatziioannou", "given": "Theodora", "initials": "T"}, {"family": "Prochazka", "given": "Jan", "initials": "J"}, {"family": "Sedlacek", "given": "Radislav", "initials": "R", "orcid": "0000-0002-3352-392X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a1594084f604610a995def1f7a6bdb2.json"}}, {"family": "Robbiani", "given": "Davide F", "initials": "DF", "orcid": "0000-0001-7379-3484", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/941e237779f74a568228c6fe1ee8800c.json"}}, {"family": "Ruzek", "given": "Daniel", "initials": "D", "orcid": "0000-0003-4655-2380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f49c5724719433ea99ebf38a4ff4a58.json"}}, {"family": "Varani", "given": "Luca", "initials": "L", "orcid": "0000-0002-0963-0987", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6c4a4cecfc04659b3b8df2b49430ba6.json"}}], "type": "journal-article", "published": "2021-05-20", "journal": {"title": "Nature", "issn": "0028-0836", "issn-l": null, "volume": "593", "issue": "7859", "pages": "424-428"}, "abstract": "Neutralizing antibodies targeting the receptor binding domain (RBD) of the SARS-CoV-2 Spike (S) are among the most promising approaches against coronavirus disease 2019 (COVID-19) 1,2 . We developed a bispecific, IgG1-like molecule based on two antibodies derived from COVID-19 convalescent donors, C121 and C135 3 . CoV-X2 simultaneously binds two independent sites on the RBD and, unlike its parental antibodies, completely prevents S binding to Angiotensin-Converting Enzyme 2 (ACE2), the virus cellular receptor. Furthermore, CoV-X2 recognizes a broad panel of RBD variants and neutralizes SARS-CoV-2 and the escape mutants generated by the single monoclonals at sub-nanomolar concentrations. In a novel model of SARS-CoV-2 infection with lung inflammation, CoV-X2 protects mice from disease and suppresses viral escape. Thus, simultaneous targeting of non-overlapping RBD epitopes by IgG-like bispecific antibodies is feasible and effective, combining into a single molecule the advantages of antibody cocktails.", "doi": "10.1038/s41586-021-03461-y", "pmid": "33501434", "labels": {"Category: Biochemistry": null, "Funder: H2020": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-18T11:10:09.811Z", "modified": "2021-06-18T11:01:30.134Z"}, {"entity": "publication", "iuid": "5e3db02127264d2e8c356e9bff7ad2dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e3db02127264d2e8c356e9bff7ad2dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e3db02127264d2e8c356e9bff7ad2dd"}}, "title": "Authors' Reply to: COVID-19 as a \"Force Majeure\" for Non-COVID-19 Clinical and Translational Research. Comment on \"Analysis of Scientific Publications During the Early Phase of the COVID-19 Pandemic: Topic Modeling Study\".", "authors": [{"family": "\u00c4lg\u00e5", "given": "Andreas", "initials": "A"}, {"family": "Eriksson", "given": "Oskar", "initials": "O"}, {"family": "Nordberg", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2021-05-20", "journal": {"title": "J Med Internet Res", "issn": "1438-8871", "volume": "23", "issue": "5", "pages": "e29156", "issn-l": null}, "abstract": null, "doi": "10.2196/29156", "pmid": "33989170", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "v23i5e29156"}], "notes": [], "created": "2021-05-21T17:02:08.259Z", "modified": "2021-05-21T17:03:39.189Z"}, {"entity": "publication", "iuid": "c3e66e3c5ab449bfb3c028254e5038fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3e66e3c5ab449bfb3c028254e5038fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3e66e3c5ab449bfb3c028254e5038fc"}}, "title": "Systematic Organization of COVID-19 Data Supported by the Adverse Outcome Pathway Framework.", "authors": [{"family": "Nymark", "given": "Penny", "initials": "P"}, {"family": "Sachana", "given": "Magdalini", "initials": "M"}, {"family": "Leite", "given": "Sofia Batista", "initials": "SB"}, {"family": "Sund", "given": "Jukka", "initials": "J"}, {"family": "Krebs", "given": "Catharine E", "initials": "CE"}, {"family": "Sullivan", "given": "Kristie", "initials": "K"}, {"family": "Edwards", "given": "Stephen", "initials": "S"}, {"family": "Viviani", "given": "Laura", "initials": "L"}, {"family": "Willett", "given": "Catherine", "initials": "C"}, {"family": "Landesmann", "given": "Brigitte", "initials": "B"}, {"family": "Wittwehr", "given": "Clemens", "initials": "C"}], "type": "journal article", "published": "2021-05-19", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "9", "issue": null, "pages": "638605"}, "abstract": "Adverse Outcome Pathways (AOP) provide structured frameworks for the systematic organization of research data and knowledge. The AOP framework follows a set of key principles that allow for broad application across diverse disciplines related to human health, including toxicology, pharmacology, virology and medical research. The COVID-19 pandemic engages a great number of scientists world-wide and data is increasing with exponential speed. Diligent data management strategies are employed but approaches for systematically organizing the data-derived information and knowledge are lacking. We believe AOPs can play an important role in improving interpretation and efficient application of scientific understanding of COVID-19. Here, we outline a newly initiated effort, the CIAO project (https://www.ciao-covid.net/), to streamline collaboration between scientists across the world toward development of AOPs for COVID-19, and describe the overarching aims of the effort, as well as the expected outcomes and research support that they will provide.", "doi": "10.3389/fpubh.2021.638605", "pmid": "34095051", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8170012"}], "notes": [], "created": "2021-06-08T08:49:30.261Z", "modified": "2021-06-08T08:53:33.409Z"}, {"entity": "publication", "iuid": "b4930e10644a4b13aa604f7263c2888b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b4930e10644a4b13aa604f7263c2888b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b4930e10644a4b13aa604f7263c2888b"}}, "title": "Social media for field epidemiologists (#SoMe4epis): How to use Twitter during the #COVID19 pandemic.", "authors": [{"family": "Hammer", "given": "Charlotte C", "initials": "CC"}, {"family": "Boender", "given": "T Sonia", "initials": "TS"}, {"family": "Thomas", "given": "Daniel Rh", "initials": "DR"}], "type": "journal article", "published": "2021-05-19", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic has fundamentally changed the way that public health professionals work and communicate. Over a very short time span, remote working arrangements have become the norm, and meetings have shifted online. Physical distancing measures have accelerated a trend toward digital communication and social exchange. At the same time, the work of epidemiologists has been held under a magnifying glass by journalists, governments and the general public, in a way not previously seen. As social media have become an inevitable part of our society over the last decade, Twitter has become a key communication tool and platform for social networking among epidemiologists (#EpiTwitter). In this article we reflect on the use of Twitter by field epidemiologists and public health microbiologists for rapid professional exchange, public communication of science, and professional development during the pandemic, as well as the associated risks. For those field epidemiologists new to social media, we discuss how Twitter can be used in a variety of ways, both at their home institutions and during field deployment. These include: information dissemination, science communication and public health advocacy, professional development, networking and experience exchange.", "doi": "10.1016/j.ijid.2021.05.035", "pmid": "34022332", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)00437-9"}], "notes": [], "created": "2021-05-29T16:24:31.698Z", "modified": "2022-11-22T05:47:08.310Z"}, {"entity": "publication", "iuid": "47be8642a1d3402f8d7f81aab73f8a34", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47be8642a1d3402f8d7f81aab73f8a34.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47be8642a1d3402f8d7f81aab73f8a34"}}, "title": "Gender and Entrepreneurship in Pandemic Time: What Demands and What Resources? An Exploratory Study.", "authors": [{"family": "De Simone", "given": "Silvia", "initials": "S"}, {"family": "Pileri", "given": "Jessica", "initials": "J"}, {"family": "Rapp-Ricciardi", "given": "Max", "initials": "M"}, {"family": "Barbieri", "given": "Barbara", "initials": "B"}], "type": "journal article", "published": "2021-05-19", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "issue": null, "pages": "668875", "issn-l": "1664-1078"}, "abstract": "Due to the coronavirus disease 2019 (COVID-19) epidemic, global economies have suffered an exogenous shock never seen before with a strong economic and psychosocial impact on organizations. Italy, in the context of the research, has been severely affected. The economic crisis has mainly affected women. In this scenario, entrepreneurial perceived success (objective and subjective) is influenced by increasingly burdensome job demands that entrepreneurs have to face up. Using the job demand-resources model, the study aims to broaden the knowledge of the determinants of entrepreneurial perceived success in the current emergency moment. In particular, as regards of the demands, alongside the specific entrepreneurial demands (time demands, uncertainty and risk, and responsibility), we also decided to include the negative interface family-work in both directions from-family-to-work (NEGWIF) and from-work-to-family (NEGFIW). Regarding the resources, we considered entrepreneurial self-efficacy (researching, planning, marshaling, implementing people, and implementing financial), proactive and elaborate social strategies (SS), and both directions of the positive interface: from-family-to-work (POSWIF) and from-work-to-family (POSFIW). All participants are women entrepreneurs ( N = 137) who have completed a self-report questionnaire. We explored the associations between demands, resources, and the dimensions of success through hierarchical regressions. As for the demands, time demands, uncertainty and risk, NEGWIF, and NEGFIW negatively influenced the perceived entrepreneurial success. Regarding resources, planning, implementing financial, proactive and elaborate SS positively influenced the perceived entrepreneurial success.", "doi": "10.3389/fpsyg.2021.668875", "pmid": "34093367", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8170095"}], "notes": [], "created": "2021-06-08T08:48:31.709Z", "modified": "2021-06-08T08:48:31.719Z"}, {"entity": "publication", "iuid": "2292c98cfe14465294b658610e6fc3a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2292c98cfe14465294b658610e6fc3a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2292c98cfe14465294b658610e6fc3a1"}}, "title": "A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection.", "authors": [{"family": "Miller", "given": "Ami", "initials": "A"}, {"family": "Leach", "given": "Adam", "initials": "A"}, {"family": "Thomas", "given": "Jemima", "initials": "J"}, {"family": "McAndrew", "given": "Craig", "initials": "C"}, {"family": "Bentley", "given": "Emma", "initials": "E"}, {"family": "Mattiuzzo", "given": "Giada", "initials": "G"}, {"family": "John", "given": "Lijo", "initials": "L"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Harris", "given": "Gemma", "initials": "G"}, {"family": "Gamage", "given": "Nadisha", "initials": "N"}, {"family": "Carr", "given": "Stephen", "initials": "S"}, {"family": "Ali", "given": "Hanif", "initials": "H"}, {"family": "Van Montfort", "given": "Rob", "initials": "R"}, {"family": "Rabbitts", "given": "Terence", "initials": "T"}], "type": "journal article", "published": "2021-05-19", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "10617", "issn-l": "2045-2322"}, "abstract": "Approaches are needed for therapy of the severe acute respiratory syndrome from SARS-CoV-2 coronavirus (COVID-19). Interfering with the interaction of viral antigens with the angiotensin converting enzyme 2 (ACE-2) receptor is a promising strategy by blocking the infection of the coronaviruses into human cells. We have implemented a novel protein engineering technology to produce a super-potent tetravalent form of ACE2, coupled to the human immunoglobulin \u03b31 Fc region, using a self-assembling, tetramerization domain from p53 protein. This high molecular weight Quad protein (ACE2-Fc-TD) retains binding to the SARS-CoV-2 receptor binding spike protein and can form a complex with the spike protein plus anti-viral antibodies. The ACE2-Fc-TD acts as a powerful decoy protein that out-performs soluble monomeric and dimeric ACE2 proteins and blocks both SARS-CoV-2 pseudovirus and SARS-CoV-2 virus infection with greatly enhanced efficacy. The ACE2 tetrameric protein complex promise to be important for development as decoy therapeutic proteins against COVID-19. In contrast to monoclonal antibodies, ACE2 decoy is unlikely to be affected by mutations in SARS-CoV-2 that are beginning to appear in variant forms. In addition, ACE2 multimeric proteins will be available as therapeutic proteins should new coronaviruses appear in the future because these are likely to interact with ACE2 receptor.", "doi": "10.1038/s41598-021-89957-z", "pmid": "34012108", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-89957-z"}], "notes": [], "created": "2021-05-21T17:17:53.522Z", "modified": "2021-05-21T17:19:09.667Z"}, {"entity": "publication", "iuid": "0d0890dfdb014f09ae619216e6d0d2a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d0890dfdb014f09ae619216e6d0d2a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d0890dfdb014f09ae619216e6d0d2a2"}}, "title": "Type-I interferon signatures in SARS-CoV-2 infected Huh7 cells.", "authors": [{"family": "Chen", "given": "Xi", "initials": "X"}, {"family": "Saccon", "given": "Elisa", "initials": "E"}, {"family": "Appelberg", "given": "K Sofia", "initials": "KS"}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "Rodriguez", "given": "Jimmy Esneider", "initials": "JE"}, {"family": "Vinhas", "given": "Beatriz S\u00e1", "initials": "BS"}, {"family": "Frisan", "given": "Teresa", "initials": "T"}, {"family": "V\u00e9gv\u00e1ri", "given": "\u00c1kos", "initials": "\u00c1"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}, {"family": "Gupta", "given": "Soham", "initials": "S"}], "type": "journal article", "published": "2021-05-18", "journal": {"title": "Cell Death Discov", "issn": "2058-7716", "issn-l": null, "volume": "7", "issue": "1", "pages": "114"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes Coronavirus disease 2019 (COVID-19) has caused a global health emergency. A key feature of COVID-19 is dysregulated interferon-response. Type-I interferon (IFN-I) is one of the earliest antiviral innate immune responses following viral infection and plays a significant role in the pathogenesis of SARS-CoV-2. In this study, using a proteomics-based approach, we identified that SARS-CoV-2 infection induces delayed and dysregulated IFN-I signaling in Huh7 cells. We demonstrate that SARS-CoV-2 is able to inhibit RIG-I mediated IFN-\u03b2 production. Our results also confirm the recent findings that IFN-I pretreatment is able to reduce the susceptibility of Huh7 cells to SARS-CoV-2, but not post-treatment. Moreover, senescent Huh7 cells, in spite of showing accentuated IFN-I response were more susceptible to SARS-CoV-2 infection, and the virus effectively inhibited IFIT1 in these cells. Finally, proteomic comparison between SARS-CoV-2, SARS-CoV, and MERS-CoV revealed a distinct differential regulatory signature of interferon-related proteins emphasizing that therapeutic strategies based on observations in SARS-CoV and MERS-CoV should be used with caution. Our findings provide a better understanding of SARS-CoV-2 regulation of cellular interferon response and a perspective on its use as a treatment. Investigation of different interferon-stimulated genes and their role in the inhibition of SARS-CoV-2 pathogenesis may direct novel antiviral strategies.", "doi": "10.1038/s41420-021-00487-z", "pmid": "34006825", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41420-021-00487-z"}, {"db": "URL", "key": "https://github.com/neogilab/COVID_IFN", "description": "Codes generated in analyzing the data"}, {"db": "URL", "key": "http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD023450", "description": "ProteomeXhanger Consortium, PXD023450"}], "notes": [], "created": "2021-05-20T14:42:46.846Z", "modified": "2021-06-04T14:47:25.536Z"}, {"entity": "publication", "iuid": "1ee5e839575a4c60a617878c3cab93bc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ee5e839575a4c60a617878c3cab93bc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ee5e839575a4c60a617878c3cab93bc"}}, "title": "Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers.", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Rosell", "given": "Axel", "initials": "A"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Mangsbo", "given": "Sara M", "initials": "SM"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2021-05-18", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484", "volume": "325", "issue": "19", "pages": "2015-2016"}, "abstract": "This cohort study describes COVID-19\u2013related symptoms persisting 8 months after SARS-CoV-2 infection among Swedish health care workers and self-reported effects of the residual symptoms on respondents\u2019 home, work, and social function.", "doi": "10.1001/jama.2021.5612", "pmid": "33825846", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC8027932"}, {"db": "pii", "key": "2778528"}], "notes": [], "created": "2021-04-09T09:00:37.481Z", "modified": "2023-01-13T13:26:19.203Z"}, {"entity": "publication", "iuid": "427d81e50b244080b398a3346744fcec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/427d81e50b244080b398a3346744fcec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/427d81e50b244080b398a3346744fcec"}}, "title": "Seropositivity in blood donors and pregnant women during the first year of SARS-CoV-2 transmission in Stockholm, Sweden.", "authors": [{"family": "Castro Dopico", "given": "X", "initials": "X"}, {"family": "Muschiol", "given": "S", "initials": "S"}, {"family": "Christian", "given": "M", "initials": "M"}, {"family": "Hanke", "given": "L", "initials": "L"}, {"family": "Sheward", "given": "D J", "initials": "DJ"}, {"family": "Grinberg", "given": "N F", "initials": "NF"}, {"family": "Rorbach", "given": "J", "initials": "J"}, {"family": "Bogdanovic", "given": "G", "initials": "G"}, {"family": "Mcinerney", "given": "G M", "initials": "GM"}, {"family": "Allander", "given": "T", "initials": "T"}, {"family": "Wallace", "given": "C", "initials": "C"}, {"family": "Murrell", "given": "B", "initials": "B"}, {"family": "Albert", "given": "J", "initials": "J"}, {"family": "Karlsson Hedestam", "given": "G B", "initials": "GB"}], "type": "journal article", "published": "2021-05-18", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "In Sweden, social restrictions to contain SARS-CoV-2 have primarily relied upon voluntary adherence to a set of recommendations. Strict lockdowns have not been enforced, potentially affecting viral dissemination. To understand the levels of past SARS-CoV-2 infection in the Stockholm population before the start of mass vaccinations, healthy blood donors and pregnant women (n = 5,100) were sampled at random between 14 March 2020 and 28 February 2021.\r\n\r\nIn this cross-sectional prospective study, otherwise-healthy blood donors (n = 2,600) and pregnant women (n = 2,500) were sampled for consecutive weeks (at four intervals) throughout the study period. Sera from all participants and a cohort of historical (negative) controls (n = 595) were screened for IgG responses against stabilized trimers of the SARS-CoV-2 spike (S) glycoprotein and the smaller receptor-binding domain (RBD). As a complement to standard analytical approaches, a probabilistic (cut-off independent) Bayesian framework that assigns likelihood of past infection was used to analyse data over time.\r\n\r\nHealthy participant samples were randomly selected from their respective pools through Karolinska University Hospital. The study was carried out in accordance with Swedish Ethical Review Authority: registration number 2020-01807.\r\n\r\nNo participants were symptomatic at sampling, and blood donors were all over the age of 18. No additional metadata were available from the participants.\r\n\r\nBlood donors and pregnant women showed a similar seroprevalence. After a steep rise at the start of the pandemic, the seroprevalence trajectory increased steadily in approach to the winter second wave of infections, approaching 15% of all individuals surveyed by 13 December 2020. By the end of February 2021, 19% of the population tested seropositive. Notably, 96% of seropositive healthy donors screened (n = 56) developed neutralizing antibody responses at titres comparable to or higher than those observed in clinical trials of SARS-CoV-2 spike mRNA vaccination, supporting that mild infection engenders a competent B-cell response.\r\n\r\nThese data indicate that in the first year since the start of community transmission, seropositivity levels in metropolitan in Stockholm had reached approximately one in five persons, providing important baseline seroprevalence information prior to the start of vaccination.", "doi": "10.1111/joim.13304", "pmid": "34008203", "labels": {"Type: Journal article": null, "Category: Serology": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-20T14:40:09.375Z", "modified": "2021-06-18T08:55:05.225Z"}, {"entity": "publication", "iuid": "acb58f22ba544e3986bb4e8945638319", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/acb58f22ba544e3986bb4e8945638319.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/acb58f22ba544e3986bb4e8945638319"}}, "title": "Living with an ever-present breathlessness: Women's experiences of living with chronic obstructive pulmonary disease stage III or IV.", "authors": [{"family": "Ekdahl", "given": "Ann", "initials": "A"}, {"family": "S\u00f6derberg", "given": "Siv", "initials": "S"}, {"family": "Rising-Holmstr\u00f6m", "given": "Malin", "initials": "M"}], "type": "journal article", "published": "2021-05-18", "journal": {"title": "Scand J Caring Sci", "issn": "1471-6712", "volume": null, "issue": null, "issn-l": null}, "abstract": "Living with chronic obstructive pulmonary disease stage III or IV has a major impact on a person's everyday life. This qualitative study focuses on women with chronic obstructive pulmonary disease stage III or IV.\n\nThe aim of this study was to describe women's experiences of living with chronic obstructive pulmonary disease stage III or IV.\n\nA purposive sample of fifteen women with chronic obstructive pulmonary disease stage III or IV participated in the study. Data were collected through individual semi-structured interviews that were subjected to qualitative content analysis.\n\nOne theme was identified, stabilizing an ever-present breathlessness by restoring strength, and three categories are as follows: managing a restricted everyday life as an expert of their illness, being afraid of contracting infections leading to suffocation and suffering and importance of continuous help and support from significant others and digital media. Breathlessness restricted women with chronic obstructive pulmonary disease, living with a body they have to wait for. Managing everyday life was adapted to their limited abilities and energy. This required detailed planning, good knowledge of their breathing and body. Women were afraid of contracting life-threatening infections that caused suffering, especially COVID-19. The fear leads to isolation and digital media was described as an important means of communication. Significant others gave support and help that was practical and emotional. Women with chronic obstructive pulmonary disease experienced lack of continuous help and support from healthcare professionals.\n\nStabilizing an ever-present breathlessness by restoring strength required women with chronic obstructive pulmonary disease stage III or IV to conduct detailed planning to manage everyday life. Being afraid of contracting infections and the consequences of suffocation had increased since the pandemic COVID-19 outbreak, which led to self-isolation and an inactive everyday life. To get help, support and socialize, women used digital media.", "doi": "10.1111/scs.12998", "pmid": "34008226", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-20T14:38:38.418Z", "modified": "2021-05-21T17:12:48.720Z"}, {"entity": "publication", "iuid": "0f2ef23eea074d47af6dfa8672fa32c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0f2ef23eea074d47af6dfa8672fa32c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0f2ef23eea074d47af6dfa8672fa32c5"}}, "title": "[Rare but potentially life-threatening - Multisystem inflammatory syndrome in adults - a case description].", "authors": [{"family": "Berntson", "given": "Lillemor", "initials": "L"}, {"family": "von Seth", "given": "Magnus", "initials": "M"}, {"family": "B\u00fclow Anderberg", "given": "Sara", "initials": "S"}, {"family": "\u00c5kerstr\u00f6m", "given": "Tobias", "initials": "T"}, {"family": "Kurland", "given": "Siri", "initials": "S"}], "type": "case reports", "published": "2021-05-17", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "118", "issue": null, "pages": null}, "abstract": "Multisystem inflammatory syndrome in adults, MIS-A, is a rare but severe post-covid-19 immunologic complication. The presentation is similar to Multisystem inflammatory syndrome in children, MIS-C. Both MIS-A/C are life-threatening immunologic syndromes characterized by hypotension, skin rashes, myocardial affection, coagulopathy and GI symptoms. Here we describe a case of MIS-A in a 35-year-old previously healthy female who, five weeks after a mild covid-19 infection, presented with a life-threatening immunological reaction. The patient made a swift recovery upon treatment with immunoglobulins, corticosteroids and an interleukin-1 receptor antagonist. We want to highlight the importance of immunological derangements following covid-19 infections in adults. We also present a treatment suggestion for MIS-A based on the management routine for MIS-C, which has been developed from international discussions and collaborations by pediatric rheumatologists in Sweden and around the world.", "doi": null, "pmid": "33999400", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "21084"}], "notes": [], "created": "2021-05-21T16:58:51.071Z", "modified": "2021-07-09T12:34:21.741Z"}, {"entity": "publication", "iuid": "8e377d87e6a14ef796a22a4cd6edc9a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e377d87e6a14ef796a22a4cd6edc9a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e377d87e6a14ef796a22a4cd6edc9a9"}}, "title": "Reorganisation of GP surgeries during the COVID-19 outbreak: analysis of guidelines from 15 countries.", "authors": [{"family": "Tsopra", "given": "Rosy", "initials": "R"}, {"family": "Frappe", "given": "Paul", "initials": "P"}, {"family": "Streit", "given": "Sven", "initials": "S"}, {"family": "Neves", "given": "Ana Luisa", "initials": "AL"}, {"family": "Honkoop", "given": "Persijn J", "initials": "PJ"}, {"family": "Espinosa-Gonzalez", "given": "Ana Belen", "initials": "AB"}, {"family": "Gero\u011flu", "given": "Berk", "initials": "B"}, {"family": "Jahr", "given": "Tobias", "initials": "T"}, {"family": "Lingner", "given": "Heidrun", "initials": "H"}, {"family": "Nessler", "given": "Katarzyna", "initials": "K"}, {"family": "Pesolillo", "given": "Gabriella", "initials": "G"}, {"family": "Sivertsen", "given": "\u00d8yvind Stople", "initials": "\u00d8S"}, {"family": "Thulesius", "given": "Hans", "initials": "H"}, {"family": "Zoitanu", "given": "Raluca", "initials": "R"}, {"family": "Burgun", "given": "Anita", "initials": "A"}, {"family": "Kinouani", "given": "Sh\u00e9razade", "initials": "S"}], "type": "journal article", "published": "2021-05-17", "journal": {"title": "BMC Fam Pract", "issn": "1471-2296", "volume": "22", "issue": "1", "pages": "96", "issn-l": null}, "abstract": "General practitioners (GPs) play a key role in managing the COVID-19 outbreak. However, they may encounter difficulties adapting their practices to the pandemic. We provide here an analysis of guidelines for the reorganisation of GP surgeries during the beginning of the pandemic from 15 countries.\n\nA network of GPs collaborated together in a three-step process: (i) identification of key recommendations of GP surgery reorganisation, according to WHO, CDC and health professional resources from health care facilities; (ii) collection of key recommendations included in the guidelines published in 15 countries; (iii) analysis, comparison and synthesis of the results.\n\nRecommendations for the reorganisation of GP surgeries of four types were identified: (i) reorganisation of GP consultations (cancelation of non-urgent consultations, follow-up via e-consultations), (ii) reorganisation of GP surgeries (area partitioning, visual alerts and signs, strict hygiene measures), (iii) reorganisation of medical examinations by GPs (equipment, hygiene, partial clinical examinations, patient education), (iv) reorganisation of GP staff (equipment, management, meetings, collaboration with the local community).\n\nWe provide here an analysis of guidelines for the reorganisation of GP surgeries during the beginning of the COVID-19 outbreak from 15 countries. These guidelines focus principally on clinical care, with less attention paid to staff management, and the area of epidemiological surveillance and research is largely neglected. The differences of guidelines between countries and the difficulty to apply them in routine care, highlight the need of advanced research in primary care. Thereby, primary care would be able to provide recommendations adapted to the real-world settings and with stronger evidence, which is especially necessary during pandemics.", "doi": "10.1186/s12875-021-01413-z", "pmid": "34000985", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12875-021-01413-z"}], "notes": [], "created": "2021-05-20T14:57:16.242Z", "modified": "2021-05-21T16:53:15.785Z"}, {"entity": "publication", "iuid": "d9f1933746cc4b67a5a451049cc1bf1a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d9f1933746cc4b67a5a451049cc1bf1a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d9f1933746cc4b67a5a451049cc1bf1a"}}, "title": "Interruption of cancer screening services due to COVID-19 pandemic: lessons from previous disasters.", "authors": [{"family": "Puricelli Perin", "given": "Douglas M", "initials": "DM"}, {"family": "Christensen", "given": "Tess", "initials": "T"}, {"family": "Bur\u00f3n", "given": "Andrea", "initials": "A"}, {"family": "Haas", "given": "Jennifer S", "initials": "JS"}, {"family": "Kamineni", "given": "Aruna", "initials": "A"}, {"family": "Pashayan", "given": "Nora", "initials": "N"}, {"family": "Rabeneck", "given": "Linda", "initials": "L"}, {"family": "Smith", "given": "Robert", "initials": "R"}, {"family": "Elfstr\u00f6m", "given": "Miriam", "initials": "M"}, {"family": "Broeders", "given": "Mireille J M", "initials": "MJM"}, {"family": "International Cancer Screening Network ICSN", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-17", "journal": {"title": "Prev Med Rep", "issn": "2211-3355", "volume": null, "issue": null, "pages": "101399", "issn-l": null}, "abstract": "To review the scientific literature seeking lessons for the COVID-19 era that could be learned from previous health services interruptions that affected the delivery of cancer screening services.\n\nA systematic search was conducted up to April 17, 2020, with no restrictions on language or dates and resulted in 385 articles. Two researchers independently assessed the list and discussed any disagreements. Once a consensus was achieved for each paper, those selected were included in the review.\n\nEleven articles were included. Three studies were based in Japan, two in the United States, one in South Korea, one in Denmark, and the remaining four offered a global perspective on interruptions in health services due to natural or human-caused disasters. No articles covered an interruption due to a pandemic. The main themes identified in the reviewed studies were coordination, communication, resource availability and patient follow-up.\n\nLessons learned applied to the context of COVID-19 are that coordination involving partners across the health sector is essential to optimize resources and resume services, making them more resilient while preparing for future interruptions. Communication with the general population about how COVID-19 has affected cancer screening, measures taken to mitigate it and safely re-establish screening services is recommended. Use of mobile health systems to reach patients who are not accessing services and the application of resource-stratified guidelines are important considerations. More research is needed to explore best strategies for suspending, resuming and sustaining cancer screening programs, and preparedness for future disruptions, adapted to diverse health care systems.", "doi": "10.1016/j.pmedr.2021.101399", "pmid": "34026465", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2211-3355(21)00089-9"}, {"db": "pmc", "key": "PMC8126519"}], "notes": [], "created": "2021-05-29T16:23:10.213Z", "modified": "2021-05-29T16:23:10.235Z"}, {"entity": "publication", "iuid": "c8c1fc225e9c47ccbc1e8ef4853d31b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c8c1fc225e9c47ccbc1e8ef4853d31b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c8c1fc225e9c47ccbc1e8ef4853d31b3"}}, "title": "Global effect of COVID-19 pandemic on physical activity, sedentary behaviour and sleep among 3- to 5-year-old children: a longitudinal study of 14 countries.", "authors": [{"family": "Okely", "given": "Anthony D", "initials": "AD"}, {"family": "Kariippanon", "given": "Katharina E", "initials": "KE"}, {"family": "Guan", "given": "Hongyan", "initials": "H"}, {"family": "Taylor", "given": "Ellie K", "initials": "EK"}, {"family": "Suesse", "given": "Thomas", "initials": "T"}, {"family": "Cross", "given": "Penny L", "initials": "PL"}, {"family": "Chong", "given": "Kar Hau", "initials": "KH"}, {"family": "Suherman", "given": "Adang", "initials": "A"}, {"family": "Turab", "given": "Ali", "initials": "A"}, {"family": "Staiano", "given": "Amanda E", "initials": "AE"}, {"family": "Ha", "given": "Amy S", "initials": "AS"}, {"family": "El Hamdouchi", "given": "Asmaa", "initials": "A"}, {"family": "Baig", "given": "Aqsa", "initials": "A"}, {"family": "Poh", "given": "Bee Koon", "initials": "BK"}, {"family": "Del Pozo-Cruz", "given": "Borja", "initials": "B"}, {"family": "Chan", "given": "Cecilia H S", "initials": "CHS"}, {"family": "Nystr\u00f6m", "given": "Christine Delisle", "initials": "CD"}, {"family": "Koh", "given": "Denise", "initials": "D"}, {"family": "Webster", "given": "E Kipling", "initials": "EK"}, {"family": "Lubree", "given": "Himangi", "initials": "H"}, {"family": "Tang", "given": "Hong Kim", "initials": "HK"}, {"family": "Baddou", "given": "Issad", "initials": "I"}, {"family": "Del Pozo-Cruz", "given": "Jesus", "initials": "J"}, {"family": "Wong", "given": "Jyh Eiin", "initials": "JE"}, {"family": "Sultoni", "given": "Kuston", "initials": "K"}, {"family": "Nacher", "given": "Maria", "initials": "M"}, {"family": "L\u00f6f", "given": "Marie", "initials": "M"}, {"family": "Cui", "given": "Mingming", "initials": "M"}, {"family": "Hossain", "given": "Mohammad Sorowar", "initials": "MS"}, {"family": "Chathurangana", "given": "P W Prasad", "initials": "PWP"}, {"family": "Kand", "given": "Uddhavi", "initials": "U"}, {"family": "Wickramasinghe", "given": "V P Pujitha", "initials": "VPP"}, {"family": "Calleia", "given": "Rebecca", "initials": "R"}, {"family": "Ferdous", "given": "Shameema", "initials": "S"}, {"family": "Van Kim", "given": "Thanh", "initials": "T"}, {"family": "Wang", "given": "Xiaojuan", "initials": "X"}, {"family": "Draper", "given": "Catherine E", "initials": "CE"}], "type": "journal article", "published": "2021-05-17", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "940"}, "abstract": "The restrictions associated with the 2020 COVID-19 pandemic has resulted in changes to young children's daily routines and habits. The impact on their participation in movement behaviours (physical activity, sedentary screen time and sleep) is unknown. This international longitudinal study compared young children's movement behaviours before and during the COVID-19 pandemic.\r\n\r\nParents of children aged 3-5 years, from 14 countries (8 low- and middle-income countries, LMICs) completed surveys to assess changes in movement behaviours and how these changes were associated with the COVID-19 pandemic. Surveys were completed in the 12 months up to March 2020 and again between May and June 2020 (at the height of restrictions). Physical activity (PA), sedentary screen time (SST) and sleep were assessed via parent survey. At Time 2, COVID-19 factors including level of restriction, environmental conditions, and parental stress were measured. Compliance with the World Health Organizations (WHO) Global guidelines for PA (180 min/day [\u226560 min moderate- vigorous PA]), SST (\u22641 h/day) and sleep (10-13 h/day) for children under 5 years of age, was determined.\r\n\r\nNine hundred- forty-eight parents completed the survey at both time points. Children from LMICs were more likely to meet the PA (Adjusted Odds Ratio [AdjOR] = 2.0, 95%Confidence Interval [CI] 1.0,3.8) and SST (AdjOR = 2.2, 95%CI 1.2,3.9) guidelines than their high-income country (HIC) counterparts. Children who could go outside during COVID-19 were more likely to meet all WHO Global guidelines (AdjOR = 3.3, 95%CI 1.1,9.8) than those who were not. Children of parents with higher compared to lower stress were less likely to meet all three guidelines (AdjOR = 0.5, 95%CI 0.3,0.9).\r\n\r\nPA and SST levels of children from LMICs have been less impacted by COVID-19 than in HICs. Ensuring children can access an outdoor space, and supporting parents' mental health are important prerequisites for enabling pre-schoolers to practice healthy movement behaviours and meet the Global guidelines.", "doi": "10.1186/s12889-021-10852-3", "pmid": "34001086", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-10852-3"}], "notes": [], "created": "2021-05-20T14:51:42.291Z", "modified": "2021-07-14T08:56:13.805Z"}, {"entity": "publication", "iuid": "d83d23d7494d4c23a2587957eff51f2e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d83d23d7494d4c23a2587957eff51f2e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d83d23d7494d4c23a2587957eff51f2e"}}, "title": "Biomimetics provides lessons from nature for contemporary ways to improve human health.", "authors": [{"family": "Stenvinkel", "given": "Peter", "initials": "P"}, {"family": "Avesani", "given": "Carla M", "initials": "CM"}, {"family": "Gordon", "given": "Line J", "initials": "LJ"}, {"family": "Schalling", "given": "Martin", "initials": "M"}, {"family": "Shiels", "given": "Paul G", "initials": "PG"}], "type": "journal article", "published": "2021-05-17", "journal": {"title": "J Clin Transl Sci", "issn": "2059-8661", "volume": "5", "issue": "1", "pages": "e128", "issn-l": null}, "abstract": "Homo sapiens is currently living in serious disharmony with the rest of the natural world. For our species to survive, and for our well-being, we must gather knowledge from multiple perspectives and actively engage in studies of planetary health. The enormous diversity of species, one of the most striking aspects of life on our planet, provides a source of solutions that have been developed through evolution by natural selection by animals living in extreme environments. The food system is central to finding solutions; our current global eating patterns have a negative impact on human health, driven climate change and loss of biodiversity. We propose that the use of solutions derived from nature, an approach termed biomimetics, could mitigate the effects of a changing climate on planetary health as well as human health. For example, activation of the transcription factor Nrf2 may play a role in protecting animals living in extreme environments, or animals exposed to heat stress, pollution and pesticides. In order to meet these challenges, we call for the creation of novel interdisciplinary planetary health research teams.", "doi": "10.1017/cts.2021.790", "pmid": "34367673", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2059866121007901"}, {"db": "pmc", "key": "PMC8327543"}], "notes": [], "created": "2021-08-11T14:34:37.080Z", "modified": "2021-08-11T14:34:37.104Z"}, {"entity": "publication", "iuid": "8904e683c1844c42b5b8b5312843711d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8904e683c1844c42b5b8b5312843711d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8904e683c1844c42b5b8b5312843711d"}}, "title": "Antiviral Activity of Silver, Copper Oxide and Zinc Oxide Nanoparticle Coatings against SARS-CoV-2.", "authors": [{"family": "Merkl", "given": "Padryk", "initials": "P"}, {"family": "Long", "given": "Siwen", "initials": "S"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}, {"family": "Sotiriou", "given": "Georgios A", "initials": "GA"}], "type": "journal article", "published": "2021-05-17", "journal": {"title": "Nanomaterials (Basel)", "issn": "2079-4991", "issn-l": null, "volume": "11", "issue": "5", "pages": null}, "abstract": "SARS-CoV-2 is responsible for several million deaths to date globally, and both fomite transmission from surfaces as well as airborne transmission from aerosols may be largely responsible for the spread of the virus. Here, nanoparticle coatings of three antimicrobial materials (Ag, CuO and ZnO) are deposited on both solid flat surfaces as well as porous filter media, and their activity against SARS-CoV-2 viability is compared with a viral plaque assay. These nanocoatings are manufactured by aerosol nanoparticle self-assembly during their flame synthesis. Nanosilver particles as a coating exhibit the strongest antiviral activity of the three studied nanomaterials, while copper oxide exhibits moderate activity, and zinc oxide does not appear to significantly reduce the virus infectivity. Thus, nanosilver and copper oxide show potential as antiviral coatings on solid surfaces and on filter media to minimize transmission and super-spreading events while also providing critical information for the current and any future pandemic mitigation efforts.", "doi": "10.3390/nano11051312", "pmid": "34067553", "labels": {"Type: Journal article": null, "Funder: H2020": null, "Funder: VR": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "nano11051312"}], "notes": [], "created": "2021-06-04T11:20:05.272Z", "modified": "2021-08-25T14:33:10.797Z"}, {"entity": "publication", "iuid": "88dc506deffe4af0bf0684e37850a9a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/88dc506deffe4af0bf0684e37850a9a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/88dc506deffe4af0bf0684e37850a9a1"}}, "title": "Evaluation of SARS-CoV-2 rapid antigen diagnostic tests for saliva samples", "authors": [{"family": "Hagbom", "given": "Marie", "initials": "M"}, {"family": "Carmona-Vicente", "given": "Noelia", "initials": "N"}, {"family": "Sharma", "given": "Sumit", "initials": "S"}, {"family": "Olsson", "given": "Henrik", "initials": "H"}, {"family": "J\u00e4mtberg", "given": "Mikael", "initials": "M"}, {"family": "Nilsdotter-Augustinsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Sj\u00f6wall", "given": "Johanna", "initials": "J"}, {"family": "Nordgren", "given": "Johan", "initials": "J"}], "type": "posted-content", "published": "2021-05-16", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.05.14.21257100", "pmid": null, "labels": {"Type: Preprint": null, "Category: Serology": null}, "xrefs": [], "notes": [], "created": "2021-05-17T19:12:07.448Z", "modified": "2021-05-18T08:00:44.306Z"}, {"entity": "publication", "iuid": "a3d7ea4ae85740d18514f0d6cce89c17", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3d7ea4ae85740d18514f0d6cce89c17.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3d7ea4ae85740d18514f0d6cce89c17"}}, "title": "Worldwide Early Impact of COVID-19 on Dialysis Patients and Staff and Lessons Learned: A DOPPS Roundtable Discussion.", "authors": [{"family": "Robinson", "given": "Bruce M", "initials": "BM"}, {"family": "Guedes", "given": "Murilo", "initials": "M"}, {"family": "Alghonaim", "given": "Mohammed", "initials": "M"}, {"family": "Cases", "given": "Aleix", "initials": "A"}, {"family": "Dasgupta", "given": "Indranil", "initials": "I"}, {"family": "Gan", "given": "Liangying", "initials": "L"}, {"family": "Jacobson", "given": "Stefan H", "initials": "SH"}, {"family": "Kanjanabuch", "given": "Talerngsak", "initials": "T"}, {"family": "Kim", "given": "Yong-Lim", "initials": "YL"}, {"family": "Kleophas", "given": "Werner", "initials": "W"}, {"family": "Labriola", "given": "Laura", "initials": "L"}, {"family": "Perlman", "given": "Rachel L", "initials": "RL"}, {"family": "Reboldi", "given": "Gianpaolo", "initials": "G"}, {"family": "Srivatana", "given": "Vesh", "initials": "V"}, {"family": "Suri", "given": "Rita S", "initials": "RS"}, {"family": "Tsuruya", "given": "Kazuhiko", "initials": "K"}, {"family": "Torres", "given": "Pablo Urena", "initials": "PU"}, {"family": "Pisoni", "given": "Ronald L", "initials": "RL"}, {"family": "Pecoits-Filho", "given": "Roberto", "initials": "R"}], "type": "journal article", "published": "2021-05-14", "journal": {"title": "Kidney Med", "issn": "2590-0595", "volume": null, "issue": null, "issn-l": null}, "abstract": "As the worst global pandemic of the past century, COVID-19 has had a disproportionate effect on maintenance dialysis patients and their health care providers. At a virtual roundtable on 12 June 2020, DOPPS investigators from fifteen countries in Asia, Europe, and the Americas described and compared the effects of COVID-19 on dialysis care, with recent updates added. Most striking is the huge difference in risk to dialysis patients and staff across the world. Per-population cases and deaths among dialysis patients vary over 100-fold across participating countries, mirroring burden in the general population. International data indicate case fatality ratio remains at 10-30% among dialysis patients, confirming the gravity of infection, and that cases are much more common among in-center than home dialysis patients. This latter finding merits urgent study because in-center patients often have greater community exposure, and in-center transmission may be uncommon under optimal protocols. Greater telemedicine use is a welcome change here to stay, and our community needs to improve emergency planning and protect dialysis staff from the next pandemic. Finally, the pandemic's challenges have prompted widespread partnering and innovation in kidney care and research that must be sustained after this global health crisis.", "doi": "10.1016/j.xkme.2021.03.006", "pmid": "34007963", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2590-0595(21)00094-7"}, {"db": "pmc", "key": "PMC8120787"}], "notes": [], "created": "2021-05-20T14:41:36.932Z", "modified": "2021-05-21T17:15:11.990Z"}, {"entity": "publication", "iuid": "344e674e29bf4ea2a231789151621751", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/344e674e29bf4ea2a231789151621751.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/344e674e29bf4ea2a231789151621751"}}, "title": "Disease surveillance for the COVID-19 era: time for bold changes.", "authors": [{"family": "Morgan", "given": "Oliver W", "initials": "OW"}, {"family": "Aguilera", "given": "Ximena", "initials": "X"}, {"family": "Ammon", "given": "Andrea", "initials": "A"}, {"family": "Amuasi", "given": "John", "initials": "J"}, {"family": "Fall", "given": "Ibrahima Soc\u00e9", "initials": "IS"}, {"family": "Frieden", "given": "Tom", "initials": "T"}, {"family": "Heymann", "given": "David", "initials": "D"}, {"family": "Ihekweazu", "given": "Chikwe", "initials": "C"}, {"family": "Jeong", "given": "Eun-Kyeong", "initials": "EK"}, {"family": "Leung", "given": "Gabriel M", "initials": "GM"}, {"family": "Mahon", "given": "Barbara", "initials": "B"}, {"family": "Nkengasong", "given": "John", "initials": "J"}, {"family": "Qamar", "given": "Farah Naz", "initials": "FN"}, {"family": "Schuchat", "given": "Anne", "initials": "A"}, {"family": "Wieler", "given": "Lothar H", "initials": "LH"}, {"family": "Dowell", "given": "Scott F", "initials": "SF"}], "type": "journal article", "published": "2021-05-14", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": null, "issue": null, "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(21)01096-5", "pmid": "34000258", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)01096-5"}, {"db": "pmc", "key": "PMC8121493"}], "notes": [], "created": "2021-05-21T16:57:57.411Z", "modified": "2021-05-21T16:57:57.422Z"}, {"entity": "publication", "iuid": "7f250fa51c5b4cf3bb2120dd63e64434", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f250fa51c5b4cf3bb2120dd63e64434.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f250fa51c5b4cf3bb2120dd63e64434"}}, "title": "Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials.", "authors": [{"family": "Axfors", "given": "Cathrine", "initials": "C"}, {"family": "Schmitt", "given": "Andreas M", "initials": "AM", "orcid": "0000-0002-9568-8164", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e04ff63fee604c08bb913012e4645bf6.json"}}, {"family": "Janiaud", "given": "Perrine", "initials": "P"}, {"family": "Van't Hooft", "given": "Janneke", "initials": "J", "orcid": "0000-0001-5303-1503", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d0cd2d5d4ae4c88bf5b3307e32869a8.json"}}, {"family": "Abd-Elsalam", "given": "Sherief", "initials": "S", "orcid": "0000-0003-4366-2218", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fb051b677594bbca20b5637fc0420a9.json"}}, {"family": "Abdo", "given": "Ehab F", "initials": "EF", "orcid": "0000-0002-9805-3850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04cb35857c4b46829ebb73f25fad291a.json"}}, {"family": "Abella", "given": "Benjamin S", "initials": "BS", "orcid": "0000-0003-2521-0891", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7572ea9966aa4951afd5d2490960148e.json"}}, {"family": "Akram", "given": "Javed", "initials": "J"}, {"family": "Amaravadi", "given": "Ravi K", "initials": "RK"}, {"family": "Angus", "given": "Derek C", "initials": "DC"}, {"family": "Arabi", "given": "Yaseen M", "initials": "YM"}, {"family": "Azhar", "given": "Shehnoor", "initials": "S"}, {"family": "Baden", "given": "Lindsey R", "initials": "LR"}, {"family": "Baker", "given": "Arthur W", "initials": "AW", "orcid": "0000-0002-0914-0291", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51dd5ed5fb784143955e3c7e587b7014.json"}}, {"family": "Belkhir", "given": "Leila", "initials": "L"}, {"family": "Benfield", "given": "Thomas", "initials": "T", "orcid": "0000-0003-0698-9385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a335d1a321c46b2a0ba4f80dc3d93b4.json"}}, {"family": "Berrevoets", "given": "Marvin A H", "initials": "MAH"}, {"family": "Chen", "given": "Cheng-Pin", "initials": "CP", "orcid": "0000-0002-0629-9790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/773f850e035a47269048204713babe5f.json"}}, {"family": "Chen", "given": "Tsung-Chia", "initials": "TC", "orcid": "0000-0002-3461-5535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2df09990f13243b6a7d586e65808f9a5.json"}}, {"family": "Cheng", "given": "Shu-Hsing", "initials": "SH", "orcid": "0000-0002-6256-0527", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44efc129a6a54e9a85422a2c1122c047.json"}}, {"family": "Cheng", "given": "Chien-Yu", "initials": "CY"}, {"family": "Chung", "given": "Wei-Sheng", "initials": "WS", "orcid": "0000-0003-4240-5690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79973df7d6b94b529a779c7b3d1bc471.json"}}, {"family": "Cohen", "given": "Yehuda Z", "initials": "YZ", "orcid": "0000-0001-6987-1478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3839874cc0f4a91a69d0fb2fc15c35a.json"}}, {"family": "Cowan", "given": "Lisa N", "initials": "LN"}, {"family": "Dalgard", "given": "Olav", "initials": "O"}, {"family": "de Almeida E Val", "given": "Fernando F", "initials": "FF"}, {"family": "de Lacerda", "given": "Marcus V G", "initials": "MVG", "orcid": "0000-0003-3374-9985", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5df56fcaab5d4fbea3ee4a973b3ed44f.json"}}, {"family": "de Melo", "given": "Gisely C", "initials": "GC"}, {"family": "Derde", "given": "Lennie", "initials": "L", "orcid": "0000-0002-3577-5629", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cdd814a355e486a88cb134b060427bc.json"}}, {"family": "Dubee", "given": "Vincent", "initials": "V", "orcid": "0000-0002-9982-4741", "researcher": {"href": 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"given": "Ronghua", "initials": "R"}, {"family": "Jurado-Camacho", "given": "Felipe", "initials": "F"}, {"family": "Khan", "given": "Khalid S", "initials": "KS"}, {"family": "Kremsner", "given": "Peter G", "initials": "PG"}, {"family": "Kreuels", "given": "Benno", "initials": "B", "orcid": "0000-0003-2315-8954", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/752c98a06cbb43f9b5b8bf63127dd654.json"}}, {"family": "Kuo", "given": "Cheng-Yu", "initials": "CY"}, {"family": "Le", "given": "Thuy", "initials": "T", "orcid": "0000-0002-3393-6580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2380b23c0d1f423aa831d72279980706.json"}}, {"family": "Lin", "given": "Yi-Chun", "initials": "YC"}, {"family": "Lin", "given": "Wu-Pu", "initials": "WP", "orcid": "0000-0002-4206-7882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86d19e5169de4a139c6508eb7bd1e085.json"}}, {"family": "Lin", "given": "Tse-Hung", "initials": "TH"}, {"family": "Lyngbakken", "given": "Magnus Nakrem", "initials": "MN", "orcid": "0000-0002-5994-9304", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70c443e4d3674615bf090ed3b0d39e98.json"}}, {"family": "McArthur", "given": "Colin", "initials": "C"}, {"family": "McVerry", "given": "Bryan J", "initials": "BJ", "orcid": "0000-0002-1175-4874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/941d8c555b224fb18d897e9201d42f35.json"}}, {"family": "Meza-Meneses", "given": "Patricia", "initials": "P", "orcid": "0000-0002-3931-3114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be8220f4a58244838e2252f67c3ea28b.json"}}, {"family": "Monteiro", "given": "Wuelton M", "initials": "WM"}, {"family": "Morpeth", "given": "Susan C", "initials": "SC"}, {"family": "Mourad", "given": "Ahmad", "initials": "A", "orcid": "0000-0002-3149-597X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3323fc32cf4e44b2b677b838954f86aa.json"}}, {"family": "Mulligan", "given": "Mark J", "initials": "MJ"}, {"family": "Murthy", "given": "Srinivas", "initials": "S"}, {"family": "Naggie", "given": "Susanna", "initials": "S"}, {"family": "Narayanasamy", "given": "Shanti", "initials": "S", "orcid": "0000-0002-6667-2868", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53cc5ca9db8d49678370dbaad3d91ac0.json"}}, {"family": "Nichol", "given": "Alistair", "initials": "A"}, {"family": "Novack", "given": "Lewis A", "initials": "LA"}, {"family": "O'Brien", "given": "Sean M", "initials": "SM"}, {"family": "Okeke", "given": "Nwora Lance", "initials": "NL"}, {"family": "Perez", "given": "L\u00e9na", "initials": "L"}, {"family": "Perez-Padilla", "given": "Rogelio", "initials": "R"}, {"family": "Perrin", "given": "Laurent", "initials": "L", "orcid": "0000-0002-1916-6639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bdac388f14a404aa6a02e69083181fb.json"}}, {"family": "Remigio-Luna", "given": "Arantxa", "initials": "A"}, {"family": "Rivera-Martinez", "given": "Norma E", "initials": "NE", "orcid": "0000-0002-6716-1234", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0214c04c5d94f0082f9068398ab6e37.json"}}, {"family": "Rockhold", "given": "Frank W", "initials": "FW", "orcid": "0000-0003-3732-4765", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/409f57f9cdcd46f7bac6c309f50f6673.json"}}, {"family": "Rodriguez-Llamazares", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-7864-8953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76eb08936ea3405eb020251713f28c3d.json"}}, {"family": "Rolfe", "given": "Robert", "initials": "R"}, {"family": "Rosa", "given": "Rossana", "initials": "R"}, {"family": "R\u00f8sj\u00f8", "given": "Helge", "initials": "H"}, {"family": "Sampaio", "given": "Vanderson S", "initials": "VS", "orcid": "0000-0001-7307-8851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/934ee588c764416998481a7dbe4aad3e.json"}}, {"family": "Seto", "given": "Todd B", "initials": "TB"}, {"family": "Shahzad", "given": "Muhammad", "initials": "M"}, {"family": "Soliman", "given": "Shaimaa", "initials": "S"}, {"family": "Stout", "given": "Jason E", "initials": "JE", "orcid": "0000-0002-6698-8176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45ca2262503a439db34471f94f65aa11.json"}}, {"family": "Thirion-Romero", "given": "Ireri", "initials": "I"}, {"family": "Troxel", "given": "Andrea B", "initials": "AB"}, {"family": "Tseng", "given": "Ting-Yu", "initials": "TY"}, {"family": "Turner", "given": "Nicholas A", "initials": "NA", "orcid": "0000-0003-0650-4894", "researcher": {"href": 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"https://publications-covid19.scilifelab.se/researcher/f6d3264c064a4675bdbde7937711265c.json"}}, {"family": "Zhong", "given": "Wu", "initials": "W", "orcid": "0000-0002-0536-620X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8058cd239379403195b1cd7d9b5ca689.json"}}, {"family": "Moher", "given": "David", "initials": "D", "orcid": "0000-0003-2434-4206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/765e99136e2943c7a7f4ce4ed5848ff9.json"}}, {"family": "Goodman", "given": "Steven N", "initials": "SN"}, {"family": "Ioannidis", "given": "John P A", "initials": "JPA", "orcid": "0000-0003-3118-6859", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9844ea41bc554157a721820d7986a442.json"}}, {"family": "Hemkens", "given": "Lars G", "initials": "LG", "orcid": "0000-0002-3444-1432", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b2562d656a74e7d91427b55ca667784.json"}}], "type": "published erratum", "published": "2021-05-14", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "3001", "issn-l": "2041-1723"}, "abstract": null, "doi": "10.1038/s41467-021-23559-1", "pmid": "33990619", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8121133"}, {"db": "pii", "key": "10.1038/s41467-021-23559-1"}], "notes": [], "created": "2021-05-17T18:41:37.862Z", "modified": "2023-06-19T15:39:56.966Z"}, {"entity": "publication", "iuid": "26c86085b9c84f40a35b66cd590454f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26c86085b9c84f40a35b66cd590454f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26c86085b9c84f40a35b66cd590454f8"}}, "title": "Changes in Availability, Utilization, and Prices of Medicines and Protection Equipment for COVID-19 in an Urban Population of Northern Nigeria.", "authors": [{"family": "Haque", "given": "Mainul", "initials": "M"}, {"family": "Abubakar", "given": "Abdullahi Rabiu", "initials": "AR"}, {"family": "Ogunleye", "given": "Olayinka O", "initials": "OO"}, {"family": "Sani", "given": "Ibrahim Haruna", "initials": "IH"}, {"family": "Sefah", "given": "Israel", "initials": "I"}, {"family": "Kurdi", "given": "Amanj", "initials": "A"}, {"family": "Islam", "given": "Salequl", "initials": "S"}, {"family": "Godman", "given": "Brian", "initials": "B"}], "type": "journal article", "published": "2021-05-13", "journal": {"title": "J Res Pharm Pract", "issn": "2319-9644", "volume": "10", "issue": "1", "pages": "17-22", "issn-l": null}, "abstract": "Measures are ongoing to prevent the spread of COVID-19 and treat it with medicines and personal protective equipment (PPE). However, there has been considerable controversy surrounding treatments such as hydroxychloroquine with misinformation fuelling prices hikes and suicides. Shortages have also appreciably increased costs of PPE, potentially catastrophic among lower- and middle-income countries such as Nigeria with high copayment levels. Consequently, a need to investigate changes in availability, utilization, and prices of relevant medicines and PPE during the pandemic in Nigeria.\n\nExploratory study among community pharmacists with a survey tool comprising four sections including questions on changes in consumption, prices, and shortages of medicines and PPE from the beginning of March 2020 to the end of June 2020. In addition, suggestions from community pharmacists and co-authors on ways to reduce misinformation.\n\n30 out of 34 pharmacists participated giving a response rate of 88.2%. Significant increases were seen (3-fold or more increase) in the consumption of hydroxychloroquine (100%), vitamins/immune boosters (96.7%) and antibiotics (46.7%) as well as PPE (100%). Considerable price increases (50% increase or greater) also seen for antimalarials (96.7%), antibiotics (93.3%), vitamins/immune boosters (66.7%), and PPE (100%). Shortages are also seen for hydroxychloroquine and vitamins/immune boosters but most severe for PPE (80% of pharmacies).\n\nEncouraging to see increases in the utilization of vitamins/immune boosters and PPE. However, a considerable increase in the utilization and prices of antimicrobials is a concern that needs addressing including misinformation. Community pharmacists have a key role in providing evidence-based advice and helping moderate prices.", "doi": "10.4103/jrpp.JRPP_20_92", "pmid": "34295848", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "JRPP-10-17"}, {"db": "pmc", "key": "PMC8259594"}], "notes": [], "created": "2021-08-05T11:08:14.212Z", "modified": "2021-08-05T11:08:14.238Z"}, {"entity": "publication", "iuid": "8aba6dd2ad9e4c22af045650c75a91d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8aba6dd2ad9e4c22af045650c75a91d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8aba6dd2ad9e4c22af045650c75a91d7"}}, "title": "A Framework-Based Approach to Assessing Mental Health Impacts of the COVID-19 Pandemic on Children and Adolescents.", "authors": [{"family": "Lin", "given": "Ping-I", "initials": "PI"}, {"family": "Srivastava", "given": "Gautam", "initials": "G"}, {"family": "Beckman", "given": "Linda", "initials": "L"}, {"family": "Kim", "given": "Yunhwan", "initials": "Y"}, {"family": "Hallerb\u00e4ck", "given": "Maria", "initials": "M"}, {"family": "Barzman", "given": "Drew", "initials": "D"}, {"family": "Sorter", "given": "Michael", "initials": "M"}, {"family": "Eapen", "given": "Valsamma", "initials": "V"}], "type": "journal article", "published": "2021-05-13", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "issue": null, "pages": "655481", "issn-l": "1664-0640"}, "abstract": "The COVID-19 pandemic has yielded extensive impacts globally in the year of 2020. Although the mental health of children and adolescents may be particularly susceptible to stressors stemming from the pandemic and anti-contagion policies, most ongoing efforts are geared toward curbing the viral spread. In the current perspective, we have identified four domains of factors corresponding to an ecological framework that may directly or indirectly influence the mental health of children and adolescents during the pandemic. The evidence suggests that anti-contagion policies might trigger cascades that impact the mental health of children and their families through multiple different sectors that used to form a safety net for youths. Additionally, children with neuropsychiatric disorders could experience exacerbated symptoms during the pandemic. Furthermore, the risk of domestic violence has surged during the pandemic, which further compounds the imminent mental health crisis. A mental health pandemic could be inevitable if no proactive prevention strategies were in place. Therefore, we recommend understanding each individual mental health risk pathway via the ecological framework in order to develop integrative prevention and intervention strategies.", "doi": "10.3389/fpsyt.2021.655481", "pmid": "34054613", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8155579"}], "notes": [], "created": "2021-06-04T11:29:09.017Z", "modified": "2021-06-04T11:29:24.098Z"}, {"entity": "publication", "iuid": "56d26eeb5c9c4efc996cfcb0c0f592be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56d26eeb5c9c4efc996cfcb0c0f592be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56d26eeb5c9c4efc996cfcb0c0f592be"}}, "title": "Prevention of COVID-19: Preventive Strategies for General Population, Healthcare Setting, and Various Professions.", "authors": [{"family": "Moossavi", "given": "Shirin", "initials": "S"}, {"family": "Fehr", "given": "Kelsey", "initials": "K"}, {"family": "Maleki", "given": "Hassan", "initials": "H"}, {"family": "Seyedpour", "given": "Simin", "initials": "S"}, {"family": "Keshavarz-Fathi", "given": "Mahdis", "initials": "M"}, {"family": "Tabasi", "given": "Farhad", "initials": "F"}, {"family": "Heravi", "given": "Mehrdad", "initials": "M"}, {"family": "Sharifian", "given": "Rayka", "initials": "R"}, {"family": "Shafiei", "given": "Golnaz", "initials": "G"}, {"family": "Badihian", "given": "Negin", "initials": "N"}, {"family": "Kelishadi", "given": "Roya", "initials": "R"}, {"family": "Nematollahi", "given": "Shahrzad", "initials": "S"}, {"family": "Almasi", "given": "Majid", "initials": "M"}, {"family": "Popescu", "given": "Saskia", "initials": "S"}, {"family": "Keshavarz-Fathi", "given": "Mahsa", "initials": "M"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}], "type": "journal article", "published": "2021-05-12", "journal": {"title": "Adv Exp Med Biol", "issn": "0065-2598", "volume": "1318", "issue": null, "pages": "575-604", "issn-l": null}, "abstract": "The disease 2019 (COVID-19) made a public health emergency in early 2020. Despite attempts for the development of therapeutic modalities, there is no effective treatment yet. Therefore, preventive measures in various settings could help reduce the burden of disease. In this chapter, the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19, non-pharmaceutical approaches at individual and population level, chemoprevention, immunoprevention, preventive measures in different healthcare settings and other professions, special considerations in high-risk groups, and the role of organizations to hamper the psychosocial effects will be discussed.", "doi": "10.1007/978-3-030-63761-3_32", "pmid": "33973200", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:54:33.345Z", "modified": "2021-05-17T18:54:33.367Z"}, {"entity": "publication", "iuid": "78f4a96977f74a7ab78fd1202cd37856", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/78f4a96977f74a7ab78fd1202cd37856.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/78f4a96977f74a7ab78fd1202cd37856"}}, "title": "Numbers don't speak for themselves: strategies of using numbers in public policy discourse.", "authors": [{"family": "Jablonka", "given": "Eva", "initials": "E", "orcid": "0000-0003-1019-792X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/99fa33b32e274c75b04539c706400382.json"}}, {"family": "Bergsten", "given": "Christer", "initials": "C", "orcid": "0000-0002-3681-3535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f9cbb818e524b0f84a84f797d6e611a.json"}}], "type": "journal article", "published": "2021-05-12", "journal": {"title": "Educ Stud Math", "issn": "1573-0816", "pages": "1-18", "issn-l": null}, "abstract": "In mathematics education, there is general agreement regarding the significance of mathematical literacy (also quantitative literacy or numeracy) for informed citizenship, which often requires evaluating the use of numbers in public policy discourse. We hold that such an evaluation must accommodate the necessarily fragile relation between the information that numbers are taken to carry and the policy decisions they are meant to support. In doing so, attention needs to be paid to differences in how that relation is formed. With this in mind, we investigated a public discourse that heavily relied on numbers in the context of introducing, maintaining, and easing the rules and regulations directed to contain the spread of the virus SARS-CoV-2 during the first epidemic wave of COVID-19 in Germany with its peak in early April 2020. We used a public-service broadcasting outlet as data. Our theoretical stance is affiliated with post-structuralist discourse theory. As an outcome, we identified four major related strategies of using numbers, which we named rationalisation, contrast, association and recharging. In our view explicit attention to these strategies as well as identifying new ones can aid the task of furthering critical mathematical literacy.", "doi": "10.1007/s10649-021-10059-8", "pmid": "34934230", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10059"}, {"db": "pmc", "key": "PMC8113797"}], "notes": [], "created": "2022-01-03T15:31:26.383Z", "modified": "2022-01-03T15:31:26.492Z"}, {"entity": "publication", "iuid": "a8681cf4f3de46409df72b9d8c08063f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8681cf4f3de46409df72b9d8c08063f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8681cf4f3de46409df72b9d8c08063f"}}, "title": "Coronavirus: Pure Infectious Disease or Genetic Predisposition.", "authors": [{"family": "Darbeheshti", "given": "Farzaneh", "initials": "F"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Bashashati", "given": "Mohammad", "initials": "M"}, {"family": "Ghavami", "given": "Saeid", "initials": "S"}, {"family": "Shahkarami", "given": "Sepideh", "initials": "S"}, {"family": "Zoghi", "given": "Samaneh", "initials": "S"}, {"family": "Gupta", "given": "Sudhir", "initials": "S"}, {"family": "Orange", "given": "Jordan S", "initials": "JS"}, {"family": "Ochs", "given": "Hans D", "initials": "HD"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}], "type": "journal article", "published": "2021-05-12", "journal": {"title": "Adv Exp Med Biol", "issn": "0065-2598", "volume": "1318", "issue": null, "pages": "91-107", "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes novel coronavirus disease (COVID-19), is the seventh pathogenic coronavirus recently discovered in December 2019 in Wuhan, China. To date, our knowledge about its effect on the human host remains limited. It is well known that host genetic factors account for the individual differences in the susceptibility to infectious diseases. The genetic susceptibility factors to COVID-19 and its severity are associated with several unanswered questions. However, the experience gained from an earlier strain of coronavirus, SARS-CoV-1, which shows 78% genetic similarity to SARS-CoV-2 and uses the same receptor to bind to host cells, could provide some clues. It, therefore, seems possible to assemble new evidence in order to solve a potential genetic predisposition puzzle for COVID-19. In this chapter, the puzzle pieces, including virus entry receptors, immune response, and inflammation-related genes, as well as the probable genetic predisposition models to COVID-19, are discussed.", "doi": "10.1007/978-3-030-63761-3_6", "pmid": "33973174", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:55:51.197Z", "modified": "2021-05-17T18:55:51.207Z"}, {"entity": "publication", "iuid": "5650033701204a63a0f7f17812cdf653", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5650033701204a63a0f7f17812cdf653.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5650033701204a63a0f7f17812cdf653"}}, "title": "Combined Cardiac Risk Factors Predict COVID-19 Related Mortality and the Need for Mechanical Ventilation in Coptic Clergy.", "authors": [{"family": "Henein", "given": "Michael Y", "initials": "MY"}, {"family": "Byty\u00e7i", "given": "Ibadete", "initials": "I"}, {"family": "Nicoll", "given": "Rachel", "initials": "R"}, {"family": "Shenouda", "given": "Rafik", "initials": "R"}, {"family": "Ayad", "given": "Sherif", "initials": "S"}, {"family": "Cameli", "given": "Matteo", "initials": "M"}, {"family": "Vancheri", "given": "Federico", "initials": "F"}], "type": "journal article", "published": "2021-05-12", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "10", "issue": "10", "issn-l": "2077-0383"}, "abstract": "The clinical adverse events of COVID-19 among clergy worldwide have been found to be higher than among ordinary communities, probably because of the nature of their work. The aim of this study was to assess the impact of cardiac risk factors on COVID-19-related mortality and the need for mechanical ventilation in Coptic clergy.\n\nOf 1570 Coptic clergy participating in the COVID-19-Clergy study, serving in Egypt, USA and Europe, 213 had the infection and were included in this analysis. Based on the presence of systemic arterial hypertension (AH), participants were divided into two groups: Group-I, clergy with AH ( n = 77) and Group-II, without AH (n = 136). Participants' demographic indices, cardiovascular risk factors, COVID-19 management details and related mortality were assessed.\n\nClergy with AH were older ( p < 0.001), more obese (p = 0.04), had frequent type 2 diabetes (DM) (p = 0.001), dyslipidemia (p = 0.001) and coronary heart disease (CHD) (p = 0.04) compared to those without AH. COVID-19 treatment at home, hospital or in intensive care did not differ between the patient groups (p > 0.05 for all). Clergy serving in Northern and Southern Egypt had a higher mortality rate compared to those from Europe and the USA combined (5.22%, 6.38%, 0%; p = 0.001). The impact of AH on mortality was significant only in Southern Egypt (10% vs. 3.7%; p = 0.01) but not in Northern Egypt (4.88% vs. 5.81%; p = 0.43). In multivariate analysis, CHD OR 1.607 ((0.982 to 3.051); p = 0.02) and obesity, OR 3.403 ((1.902 to 4.694); p = 0.04) predicted COVID-19 related mortality. A model combining cardiac risk factors (systolic blood pressure (SBP) \u2265 160 mmHg, DM, obesity and history of CHD) was the most powerful independent predictor of COVID-19-related mortality, OR 3.991 ((1.919 to 6.844); p = 0.002). Almost the same model also proved the best independent multivariate predictor of mechanical ventilation OR 1.501 ((0.809 to 6.108); p = 0.001).\n\nIn Coptic clergy, the cumulative impact of risk factors was the most powerful predictor of mortality and the need for mechanical ventilation.", "doi": "10.3390/jcm10102066", "pmid": "34065902", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jcm10102066"}], "notes": [], "created": "2021-06-04T11:23:13.799Z", "modified": "2021-06-04T11:23:36.205Z"}, {"entity": "publication", "iuid": "b9123a86798d42579531d0a65f4020b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9123a86798d42579531d0a65f4020b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9123a86798d42579531d0a65f4020b2"}}, "title": "COVID-19 in Patients with Cancer.", "authors": [{"family": "Nowroozi", "given": "Ali", "initials": "A"}, {"family": "Razi", "given": "Sepideh", "initials": "S"}, {"family": "Sahu", "given": "Kamal Kant", "initials": "KK"}, {"family": "Grizzi", "given": "Fabio", "initials": "F"}, {"family": "Arends", "given": "Jann", "initials": "J"}, {"family": "Keshavarz-Fathi", "given": "Mahsa", "initials": "M"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}], "type": "journal article", "published": "2021-05-12", "journal": {"title": "Adv Exp Med Biol", "issn": "0065-2598", "volume": "1318", "issue": null, "pages": "315-331", "issn-l": null}, "abstract": "With more than 5 million cases and 333,212 deaths, COVID-19 (or SARS-CoV-2) continues to spread. General symptoms of this disease are similar to that of many other viral respiratory diseases, including fever, cough, dyspnea, and fatigue, with a chance of progression to more severe complications. However, the virus does not affect all people equally, and cases with comorbidities such as malignancies, cardiovascular diseases, respiratory diseases, and kidney diseases are at higher risk of developing severe events, including requiring intensive ventilation, intensive care unit (ICU) admission, and death. Patients with cancer are more likely to be infected with COVID-19, which is possibly due to their immunological dysfunction or frequent clinic visits. Also, there is a higher chance that these patients experience severe events because of the medication they receive. In this chapter, we will review the main clinical manifestations of COVID-19 in patients with cancer. Recommendations and challenges for managing resources, organizing cancer centers, treatment of COVID-19-infected cancer patients, and performing cancer research during this pandemic will also be discussed.", "doi": "10.1007/978-3-030-63761-3_18", "pmid": "33973186", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:55:05.544Z", "modified": "2021-05-17T18:55:05.556Z"}, {"entity": "publication", "iuid": "a4272f9b05514336a607b145e6c4528a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a4272f9b05514336a607b145e6c4528a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a4272f9b05514336a607b145e6c4528a"}}, "title": "Beyond brick and mortar: staying connected in post-pandemic blended learning environments.", "authors": [{"family": "McGrath", "given": "Cormac", "initials": "C"}, {"family": "Palmgren", "given": "Per J", "initials": "PJ"}, {"family": "Liljedahl", "given": "Matilda", "initials": "M"}], "type": "journal article", "published": "2021-05-12", "journal": {"title": "Med Educ", "issn": "1365-2923", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "These are certainly unprecedented times and the ongoing Covid-19 pandemic has turned many ideas about teaching and learning in medical education on their head. Who would have thought that, overnight, brick and mortar universities would be providing education solely through digital means? This form of radical change comes along perhaps once in a lifetime, and currently we have not seen the full fallout, or the potential benefits from the sudden and dramatic shift in medical education. More than a year later, we still find ourselves telecommuting in front of our screens; teaching, supervising, and assessing.", "doi": "10.1111/medu.14546", "pmid": "33977575", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:47:19.209Z", "modified": "2022-11-22T05:47:36.508Z"}, {"entity": "publication", "iuid": "6bed9e4cb4c945d8b93a6c6339fd8fa8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6bed9e4cb4c945d8b93a6c6339fd8fa8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6bed9e4cb4c945d8b93a6c6339fd8fa8"}}, "title": "Use of repurposed and adjuvant drugs in hospital patients with covid-19: multinational network cohort study.", "authors": [{"family": "Prats-Uribe", "given": "Albert", "initials": "A"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Lai", "given": "Lana Yin Hui", "initials": "LYH"}, {"family": "Ahmed", "given": "Waheed-Ul-Rahman", "initials": "WU"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Carter", "given": "William", "initials": "W"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "Dawoud", "given": "Dalia", "initials": "D"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Jonnagaddala", "given": "Jitendra", "initials": "J"}, {"family": "Mehta", "given": "Paras P", "initials": "PP"}, {"family": "Gong", "given": "Mengchun", "initials": "M"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Recalde", "given": "Martina", "initials": "M"}, {"family": "Roel", "given": "Elena", "initials": "E"}, {"family": "Shah", "given": "Karishma", "initials": "K"}, {"family": "Shah", "given": "Nigam H", "initials": "NH"}, {"family": "Schilling", "given": "Lisa M", "initials": "LM"}, {"family": "Subbian", "given": "Vignesh", "initials": "V"}, {"family": "Vizcaya", "given": "David", "initials": "D"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhang", "given": "Ying", "initials": "Y"}, {"family": "Zhu", "given": "Hong", "initials": "H"}, {"family": "Liu", "given": "Li", "initials": "L"}, {"family": "Cho", "given": "Jaehyeong", "initials": "J"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Lane", "given": "Jennifer Ce", "initials": "JC"}, {"family": "Burn", "given": "Edward", "initials": "E"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Ryan", "given": "Patrick B", "initials": "PB", "orcid": "0000-0002-9727-2138", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7f5f6d8b6bb4d85b1430cda6aea55b8.json"}}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "373", "issue": null, "pages": "n1038", "issn-l": null}, "abstract": "To investigate the use of repurposed and adjuvant drugs in patients admitted to hospital with covid-19 across three continents.\n\nMultinational network cohort study.\n\nHospital electronic health records from the United States, Spain, and China, and nationwide claims data from South Korea.\n\n303 264 patients admitted to hospital with covid-19 from January 2020 to December 2020.\n\nPrescriptions or dispensations of any drug on or 30 days after the date of hospital admission for covid-19.\n\nOf the 303 264 patients included, 290 131 were from the US, 7599 from South Korea, 5230 from Spain, and 304 from China. 3455 drugs were identified. Common repurposed drugs were hydroxychloroquine (used in from <5 (<2%) patients in China to 2165 (85.1%) in Spain), azithromycin (from 15 (4.9%) in China to 1473 (57.9%) in Spain), combined lopinavir and ritonavir (from 156 (<2%) in the VA-OMOP US to 2,652 (34.9%) in South Korea and 1285 (50.5%) in Spain), and umifenovir (0% in the US, South Korea, and Spain and 238 (78.3%) in China). Use of adjunctive drugs varied greatly, with the five most used treatments being enoxaparin, fluoroquinolones, ceftriaxone, vitamin D, and corticosteroids. Hydroxychloroquine use increased rapidly from March to April 2020 but declined steeply in May to June and remained low for the rest of the year. The use of dexamethasone and corticosteroids increased steadily during 2020.\n\nMultiple drugs were used in the first few months of the covid-19 pandemic, with substantial geographical and temporal variation. Hydroxychloroquine, azithromycin, lopinavir-ritonavir, and umifenovir (in China only) were the most prescribed repurposed drugs. Antithrombotics, antibiotics, H2 receptor antagonists, and corticosteroids were often used as adjunctive treatments. Research is needed on the comparative risk and benefit of these treatments in the management of covid-19.", "doi": "10.1136/bmj.n1038", "pmid": "33975825", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC8111167"}], "notes": [], "created": "2021-05-17T18:47:58.975Z", "modified": "2023-06-19T15:36:24.527Z"}, {"entity": "publication", "iuid": "29339962371649a685dbe773e103b82d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/29339962371649a685dbe773e103b82d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/29339962371649a685dbe773e103b82d"}}, "title": "Transformation of primary care during the COVID-19 pandemic: experiences of healthcare professionals in eight European countries.", "authors": [{"family": "Wanat", "given": "Marta", "initials": "M"}, {"family": "Hoste", "given": "Melanie", "initials": "M"}, {"family": "Gobat", "given": "Nina", "initials": "N"}, {"family": "Anastasaki", "given": "Marilena", "initials": "M"}, {"family": "Boehmer", "given": "Femke", "initials": "F"}, {"family": "Chlabicz", "given": "Slawomir", "initials": "S"}, {"family": "Colliers", "given": "Annelies", "initials": "A"}, {"family": "Farrell", "given": "Karen", "initials": "K"}, {"family": "Karkana", "given": "Maria-Nefeli", "initials": "MN"}, {"family": "Kinsman", "given": "John", "initials": "J"}, {"family": "Lionis", "given": "Christos", "initials": "C"}, {"family": "Marcinowicz", "given": "Ludmila", "initials": "L"}, {"family": "Reinhardt", "given": "Katrin", "initials": "K"}, {"family": "Skoglund", "given": "Ingmarie", "initials": "I"}, {"family": "Sundvall", "given": "P\u00e4r-Daniel", "initials": "PD"}, {"family": "Vellinga", "given": "Akke", "initials": "A"}, {"family": "Verheij", "given": "Theo", "initials": "T"}, {"family": "Goossens", "given": "Herman", "initials": "H"}, {"family": "Butler", "given": "Christopher", "initials": "C"}, {"family": "van der Velden", "given": "Alike", "initials": "A"}, {"family": "Anthierens", "given": "Sibyl", "initials": "S"}, {"family": "Tonkin-Crine", "given": "Sarah", "initials": "S"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Br J Gen Pract", "issn": "1478-5242", "volume": null, "issue": null, "issn-l": null}, "abstract": "Primary care has a crucial role in responding to the COVID-19 pandemic as the first point of patient care and gatekeeper to secondary care. Qualitative studies exploring the experiences of healthcare professionals during the COVID-19 pandemic have mainly focused on secondary care.\n\nTo understand the experiences of European PCPs working during the first peak of the COVID-19 pandemic.\n\nAn exploratory qualitative study, using semi-structured interviews in primary care in England, Belgium, the Netherlands, Ireland, Germany, Poland, Greece and Sweden, between April and July 2020.\n\nInterviews were audio recorded, transcribed and analysed using a combination of inductive and deductive thematic analysis techniques.\n\nEighty interviews were conducted with PCPs. PCPs had to make their own decisions on how to rapidly transform services in relation to COVID-19 and non-COVID-19 care. Despite being overwhelmed with guidance, they often lacked access to practical training. Consequently, PCPs turned to their colleagues for moral support and information to try to quickly adjust to new ways of working, including remote care, and deal with uncertainty.\n\nPCPs rapidly transformed primary care delivery despite a number of challenges. Representation of primary care at policy level and engagement with local primary care champions will facilitate easy and coordinated access to practical information on how to adapt services, ongoing training and access to appropriate mental health support services for PCPs. Preservation of autonomy and responsiveness of primary care are critical to preserve the ability for rapid transformation in any future crisis of care delivery.", "doi": "10.3399/BJGP.2020.1112", "pmid": "33979303", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "BJGP.2020.1112"}], "notes": [], "created": "2021-05-17T18:43:33.883Z", "modified": "2021-05-21T17:01:41.572Z"}, {"entity": "publication", "iuid": "e215aad9f53e4b84850559d85c40ea41", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e215aad9f53e4b84850559d85c40ea41.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e215aad9f53e4b84850559d85c40ea41"}}, "title": "The perfect storm: Disruptions to institutional delivery care arising from the COVID-19 pandemic in Nepal.", "authors": [{"family": "Ashish", "given": "K C", "initials": "KC"}, {"family": "Peterson", "given": "Stefan Swartling", "initials": "SS"}, {"family": "Gurung", "given": "Rejina", "initials": "R"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A"}, {"family": "Gautam", "given": "Jageshwar", "initials": "J"}, {"family": "Malla", "given": "Honey", "initials": "H"}, {"family": "Paudel", "given": "Punya", "initials": "P"}, {"family": "Bhattarai", "given": "Kumari", "initials": "K"}, {"family": "Joshi", "given": "Nisha", "initials": "N"}, {"family": "Tinkari", "given": "Bhim Singh", "initials": "BS"}, {"family": "Adhikari", "given": "Shree", "initials": "S"}, {"family": "Shrestha", "given": "Durgalaxmi", "initials": "D"}, {"family": "Ghimire", "given": "Binda", "initials": "B"}, {"family": "Sharma", "given": "Seema", "initials": "S"}, {"family": "Khanal", "given": "Laxmi", "initials": "L"}, {"family": "Shrestha", "given": "Sunil", "initials": "S"}, {"family": "Graham", "given": "Wendy Jane", "initials": "WJ"}, {"family": "Kinney", "given": "Mary", "initials": "M"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "J Glob Health", "issn": "2047-2986", "volume": "11", "issue": null, "pages": "05010", "issn-l": "2047-2978"}, "abstract": "The COVID-19 pandemic has led to system-wide disruption of health services globally. We assessed the effect of the pandemic on the disruption of institutional delivery care in Nepal.\n\nWe conducted a prospective cohort study among 52 356 women in nine hospitals to assess the disruption of institutional delivery care during the pandemic (comparing March to August in 2019 with the same months in 2020). We also conducted a nested follow up cohort study with 2022 women during the pandemic to assess their provision and experience of respectful care. We used linear regression models to assess the association between provision and experience of care with volume of hospital births and women's residence in a COVID-19 hotspot area.\n\nThe mean institutional births during the pandemic across the nine hospitals was 24 563, an average decrease of 11.6% ( P < 0.0001) in comparison to the same time-period in 2019. The institutional birth in high-medium volume hospitals declined on average by 20.8% (P < 0.0001) during the pandemic, whereas in low-volume hospital institutional birth increased on average by 7.9% (P = 0.001). Maternity services halted for a mean of 4.3 days during the pandemic and there was a redeployment staff to COVID-19 dedicated care. Respectful provision of care was better in hospitals with low-volume birth (\u03b2 = 0.446, P < 0.0001) in comparison to high-medium-volume hospitals. There was a positive association between women's residence in a COVID-19 hotspot area and respectful experience of care (\u03b2 = 0.076, P = 0.001).\n\nThe COVID-19 pandemic has had differential effects on maternity services with changes varying by the volume of births per hospital with smaller volume facilities doing better. More research is needed to investigate the effects of the pandemic on where women give birth and their provision and experience of respectful maternity care to inform a \"building-back-better\" approach in post-pandemic period.", "doi": "10.7189/jogh.11.05010", "pmid": "34055329", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "jogh-11-05010"}, {"db": "pmc", "key": "PMC8141327"}], "notes": [], "created": "2021-06-04T11:28:42.299Z", "modified": "2021-06-04T11:28:42.309Z"}, {"entity": "publication", "iuid": "40cf5150085a4046a75dc1f9fe386a62", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/40cf5150085a4046a75dc1f9fe386a62.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/40cf5150085a4046a75dc1f9fe386a62"}}, "title": "Social distancing during the COVID-19 pandemic and health-related quality of life among esophageal cancer survivors.", "authors": [{"family": "Schandl", "given": "Anna", "initials": "A"}, {"family": "M\u00e4lberg", "given": "Kalle", "initials": "K"}, {"family": "Johar", "given": "Asif", "initials": "A"}, {"family": "Lagergren", "given": "Pernilla", "initials": "P"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Acta Oncol", "issn": "1651-226X", "volume": null, "issue": null, "pages": "1-8", "issn-l": null}, "abstract": "The purpose was to investigate whether social distancing during the COVID-19 pandemic reduced health-related quality of life (HRQL) in esophageal cancer patients and if so, to identify factors related to the HRQL changes.\n\nA prospective Swedish nationwide study of patients who undergone surgery for esophageal cancer between 2013 and 2019. Telephone interviews were conducted 5 weeks and 13 weeks after the introduction of social distancing recommendations. The participants responded to a few scales and items from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30. Regression models adjusted for potential confounders were used to examine mean score differences (MSD) with 95% confidence intervals (CI) between compliance with the recommendations and HRQL.\n\nIn total, 134 individuals participated in the study. At 5 weeks, a reduction in role function was seen for individuals who fully (MSD -8, 95% CI: -16 to 0) and to a large extent (MSD -19, 95% CI: -26 to -12) complied with the recommendations. Less fatigue (MSD 9, 95% CI: 3-15) was also detected for this group. Being female, elderly, having comorbidities, living in a region with higher COVID-19 incidence, living in a villa, and being considered as an at-risk person were related to changes in role function. At 13 weeks, reductions in role function continued for those who fully complied with the recommendations (MSD -10, 95% CI: -19 to -1), but the risk variables were of less importance. Improvements in fatigue were no longer detected. Global quality of life, emotional function, or insomnia remained stable over time.\n\nThis study indicates that individuals who undergone surgery for esophageal cancer and fully or to a large extent complied with the recommendations experienced reductions in role function, but not in global quality of life or emotional function, during the COVID-19 pandemic.", "doi": "10.1080/0284186X.2021.1921260", "pmid": "33974501", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:50:05.413Z", "modified": "2021-05-17T18:50:05.423Z"}, {"entity": "publication", "iuid": "762b430a5e3b4c3d809a370ec4193981", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/762b430a5e3b4c3d809a370ec4193981.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/762b430a5e3b4c3d809a370ec4193981"}}, "title": "Post-outbreak serological screening for SARS-CoV-2 infection in healthcare workers at a Swedish University Hospital.", "authors": [{"family": "Strand", "given": "Rasmus", "initials": "R"}, {"family": "Fernstr\u00f6m", "given": "Nils", "initials": "N"}, {"family": "Holmberg", "given": "Anna", "initials": "A"}, {"family": "De Marinis", "given": "Yang", "initials": "Y"}, {"family": "Fraenkel", "given": "Carl-Johan", "initials": "C"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": null, "issue": null, "pages": "1-6"}, "abstract": "Nosocomial outbreaks of coronavirus disease 2019 (COVID-19) can have devastating consequences from both a resource cost and patient healthcare perspective. Relying on reverse transcription-polymerase chain reaction (RT-PCR) for identifying infected individuals may result in missed cases. Screening for antibodies after an outbreak can help to find missed cases and better illuminate routes of transmission.\r\n\r\nIn this study, we present the results of a serological screening of the healthcare workers (HCWs) on a ward for infectious diseases in Sweden with a point-of-care antibody test 8 weeks after an outbreak of COVID-19. In all, 107/123 (87%) of HCWs who were tested with RT-PCR in the outbreak investigation participated in this study on seroprevalence. Participants were also asked to fill out a questionnaire entailing epidemiological data. The cohort was stratified by RT-PCR result and the resulting groups were compared to each other.\r\n\r\nSix (8%) HCWs who were tested RT-PCR negative during the outbreak investigation had developed specific IgG antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These HCWs had all worked shifts with colleagues who later were tested RT-PCR positive during the outbreak.\r\n\r\nOur results indicate that a serological follow-up screening after an outbreak may be used as a complement to virus detection in an outbreak situation. However, immunoglobulin (Ig) G-detection should also be performed at the start of an outbreak, to facilitate interpretation of the results.", "doi": "10.1080/23744235.2021.1925739", "pmid": "33974498", "labels": {"Type: Journal article": null, "Category: Serology": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:51:24.712Z", "modified": "2021-06-18T08:53:08.301Z"}, {"entity": "publication", "iuid": "930d2a63267f4a5babddd655671ec80b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/930d2a63267f4a5babddd655671ec80b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/930d2a63267f4a5babddd655671ec80b"}}, "title": "Nutritional management of individuals with obesity and COVID-19: ESPEN expert statements and practical guidance.", "authors": [{"family": "Barazzoni", "given": "Rocco", "initials": "R"}, {"family": "Bischoff", "given": "Stephan C", "initials": "SC"}, {"family": "Busetto", "given": "Luca", "initials": "L"}, {"family": "Cederholm", "given": "Tommy", "initials": "T"}, {"family": "Chourdakis", "given": "Michael", "initials": "M"}, {"family": "Cuerda", "given": "Cristina", "initials": "C"}, {"family": "Delzenne", "given": "Nathalie", "initials": "N"}, {"family": "Genton", "given": "Laurence", "initials": "L"}, {"family": "Schneider", "given": "Stephane", "initials": "S"}, {"family": "Singer", "given": "Pierre", "initials": "P"}, {"family": "Boirie", "given": "Yves", "initials": "Y"}, {"family": "endorsed by the ESPEN Council", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Clin Nutr", "issn": "1532-1983", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemics has created unprecedented challenges and threats to patients and healthcare systems worldwide. Acute respiratory complications that require intensive care unit (ICU) management are a major cause of morbidity and mortality in COVID-19 patients. Among other important risk factors for severe COVID-19 outcomes, obesity has emerged along with undernutrition-malnutrition as a strong predictor of disease risk and severity. Obesity-related excessive body fat may lead to respiratory, metabolic and immune derangements potentially favoring the onset of COVID-19 complications. In addition, patients with obesity may be at risk for loss of skeletal muscle mass, reflecting a state of hidden malnutrition with a strong negative health impact in all clinical settings. Also importantly, obesity is commonly associated with micronutrient deficiencies that directly influence immune function and infection risk. Finally, the pandemic-related lockdown, deleterious lifestyle changes and other numerous psychosocial consequences may worsen eating behaviors, sedentarity, body weight regulation, ultimately leading to further increments of obesity-associated metabolic complications with loss of skeletal muscle mass and higher non-communicable disease risk. Therefore, prevention, diagnosis and treatment of malnutrition and micronutrient deficiencies should be routinely included in the management of COVID-19 patients in the presence of obesity; lockdown-induced health risks should also be specifically monitored and prevented in this population. In the current document, the European Society for Clinical Nutrition and Metabolism (ESPEN) aims at providing clinical practice guidance for nutritional management of COVID-19 patients with obesity in various clinical settings.", "doi": "10.1016/j.clnu.2021.05.006", "pmid": "34140163", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0261-5614(21)00248-X"}, {"db": "pmc", "key": "PMC8110326"}], "notes": [], "created": "2021-06-28T18:30:11.127Z", "modified": "2021-06-28T18:30:42.013Z"}, {"entity": "publication", "iuid": "3a2fb90fbc5c49049f3760352f9c6421", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a2fb90fbc5c49049f3760352f9c6421.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a2fb90fbc5c49049f3760352f9c6421"}}, "title": "Institutional and behaviour-change interventions to support COVID-19 public health measures: a review by the Lancet Commission Task Force on public health measures to suppress the pandemic.", "authors": [{"family": "Lee", "given": "Jong-Koo", "initials": "JK"}, {"family": "Bullen", "given": "Chris", "initials": "C"}, {"family": "Ben Amor", "given": "Yanis", "initials": "Y"}, {"family": "Bush", "given": "Simon R", "initials": "SR"}, {"family": "Colombo", "given": "Francesca", "initials": "F"}, {"family": "Gaviria", "given": "Alejandro", "initials": "A"}, {"family": "Karim", "given": "Salim S Abdool", "initials": "SSA"}, {"family": "Kim", "given": "Booyuel", "initials": "B"}, {"family": "Lavis", "given": "John N", "initials": "JN"}, {"family": "Lazarus", "given": "Jeffrey V", "initials": "JV"}, {"family": "Lo", "given": "Yi-Chun", "initials": "YC"}, {"family": "Michie", "given": "Susan F", "initials": "SF"}, {"family": "Norheim", "given": "Ole F", "initials": "OF"}, {"family": "Oh", "given": "Juhwan", "initials": "J"}, {"family": "Reddy", "given": "Kolli Srinath", "initials": "KS"}, {"family": "Rostila", "given": "Mikael", "initials": "M"}, {"family": "S\u00e1enz", "given": "Roc\u00edo", "initials": "R"}, {"family": "Smith", "given": "Liam D G", "initials": "LDG"}, {"family": "Thwaites", "given": "John W", "initials": "JW"}, {"family": "Were", "given": "Miriam K", "initials": "MK"}, {"family": "Xue", "given": "Lan", "initials": "L"}, {"family": "(The Lancet COVID-19 Commission Task Force for Public Health Measures to Suppress the Pandemic)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Int Health", "issn": "1876-3405", "volume": null, "issue": null, "issn-l": null}, "abstract": "The Lancet COVID-19 Commission Task Force for Public Health Measures to Suppress the Pandemic was launched to identify critical points for consideration by governments on public health interventions to control coronavirus disease 2019 (COVID-19). Drawing on our review of published studies of data analytics and modelling, evidence synthesis and contextualisation, and behavioural science evidence and theory on public health interventions from a range of sources, we outline evidence for a range of institutional measures and behaviour-change measures. We cite examples of measures adopted by a range of countries, but especially jurisdictions that have, thus far, achieved low numbers of COVID-19 deaths and limited community transmission of severe acute respiratory syndrome coronavirus 2. Finally, we highlight gaps in knowledge where research should be undertaken. As countries consider long-term measures, there is an opportunity to learn, improve the response and prepare for future pandemics.", "doi": "10.1093/inthealth/ihab022", "pmid": "33974687", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "6273788"}], "notes": [], "created": "2021-05-17T18:49:29.351Z", "modified": "2021-05-17T18:49:41.581Z"}, {"entity": "publication", "iuid": "fa6a7a05e2074cd1a7402b7d09a56c8e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa6a7a05e2074cd1a7402b7d09a56c8e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa6a7a05e2074cd1a7402b7d09a56c8e"}}, "title": "High but slightly declining COVID-19 vaccine acceptance and reasons for vaccine acceptance, Finland April to December 2020.", "authors": [{"family": "Hammer", "given": "Charlotte C", "initials": "CC"}, {"family": "Cristea", "given": "Veronica", "initials": "V"}, {"family": "Dub", "given": "Timothee", "initials": "T"}, {"family": "Sivel\u00e4", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "issn-l": null, "volume": null, "issue": null, "pages": "1-19"}, "abstract": null, "doi": "10.1017/S0950268821001114", "pmid": "33972001", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0950268821001114"}], "notes": [], "created": "2021-05-17T18:56:22.538Z", "modified": "2021-07-14T08:51:02.585Z"}, {"entity": "publication", "iuid": "eadf0103347c4a33b1fe4952b6eec997", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eadf0103347c4a33b1fe4952b6eec997.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eadf0103347c4a33b1fe4952b6eec997"}}, "title": "Evidence-Based Health Informatics as the Foundation for the COVID-19 Response: A Joint Call for Action.", "authors": [{"family": "Fernandez-Luque", "given": "Luis", "initials": "L"}, {"family": "Kushniruk", "given": "Andre W", "initials": "AW"}, {"family": "Georgiou", "given": "Andrew", "initials": "A"}, {"family": "Basu", "given": "Arindam", "initials": "A"}, {"family": "Petersen", "given": "Carolyn", "initials": "C"}, {"family": "Ronquillo", "given": "Charlene", "initials": "C"}, {"family": "Paton", "given": "Chris", "initials": "C"}, {"family": "N\u00f8hr", "given": "Christian", "initials": "C"}, {"family": "Kuziemsky", "given": "Craig E", "initials": "CE"}, {"family": "Alhuwail", "given": "Dari", "initials": "D"}, {"family": "Skiba", "given": "Diane", "initials": "D"}, {"family": "Huesing", "given": "Elaine", "initials": "E"}, {"family": "Gabarron", "given": "Elia", "initials": "E"}, {"family": "Borycki", "given": "Elizabeth M", "initials": "EM"}, {"family": "Magrabi", "given": "Farah", "initials": "F"}, {"family": "Denecke", "given": "Kerstin", "initials": "K"}, {"family": "Peute", "given": "Linda W P", "initials": "LWP"}, {"family": "Topaz", "given": "Max", "initials": "M"}, {"family": "Al-Shorbaji", "given": "Najeeb", "initials": "N"}, {"family": "Lacroix", "given": "Paulette", "initials": "P"}, {"family": "Marcilly", "given": "Romaric", "initials": "R"}, {"family": "Cornet", "given": "Ronald", "initials": "R"}, {"family": "Gogia", "given": "Shashi B", "initials": "SB"}, {"family": "Kobayashi", "given": "Shinji", "initials": "S"}, {"family": "Iyengar", "given": "Sriram", "initials": "S"}, {"family": "Deserno", "given": "Thomas M", "initials": "TM"}, {"family": "Mettler", "given": "Tobias", "initials": "T"}, {"family": "Vimarlund", "given": "Vivian", "initials": "V"}, {"family": "Zhu", "given": "Xinxin", "initials": "X"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Methods Inf Med", "issn": "2511-705X", "volume": null, "issue": null, "issn-l": null}, "abstract": "As a major public health crisis, the novel coronavirus disease 2019 (COVID-19) pandemic demonstrates the urgent need for safe, effective, and evidence-based implementations of digital health. The urgency stems from the frequent tendency to focus attention on seemingly high promising digital health interventions despite being poorly validated in times of crisis.\n\nIn this paper, we describe a joint call for action to use and leverage evidence-based health informatics as the foundation for the COVID-19 response and public health interventions. Tangible examples are provided for how the working groups and special interest groups of the International Medical Informatics Association (IMIA) are helping to build an evidence-based response to this crisis.\n\nLeaders of working and special interest groups of the IMIA, a total of 26 groups, were contacted via e-mail to provide a summary of the scientific-based efforts taken to combat COVID-19 pandemic and participate in the discussion toward the creation of this manuscript. A total of 13 groups participated in this manuscript.\n\nVarious efforts were exerted by members of IMIA including (1) developing evidence-based guidelines for the design and deployment of digital health solutions during COVID-19; (2) surveying clinical informaticians internationally about key digital solutions deployed to combat COVID-19 and the challenges faced when implementing and using them; and (3) offering necessary resources for clinicians about the use of digital tools in clinical practice, education, and research during COVID-19.\n\nRigor and evidence need to be taken into consideration when designing, implementing, and using digital tools to combat COVID-19 to avoid delays and unforeseen negative consequences. It is paramount to employ a multidisciplinary approach for the development and implementation of digital health tools that have been rapidly deployed in response to the pandemic bearing in mind human factors, ethics, data privacy, and the diversity of context at the local, national, and international levels. The training and capacity building of front-line workers is crucial and must be linked to a clear strategy for evaluation of ongoing experiences.", "doi": "10.1055/s-0041-1726414", "pmid": "33975375", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:48:34.073Z", "modified": "2021-05-17T18:48:43.627Z"}, {"entity": "publication", "iuid": "aa21976a6f8245e8b4dd38c8e7bc90af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aa21976a6f8245e8b4dd38c8e7bc90af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aa21976a6f8245e8b4dd38c8e7bc90af"}}, "title": "COVID-19, Livestock Systems and Food Security in Developing Countries: A Systematic Review of an Emerging Literature.", "authors": [{"family": "Abu Hatab", "given": "Assem", "initials": "A"}, {"family": "Krautscheid", "given": "Lena", "initials": "L"}, {"family": "Boqvist", "given": "Sofia", "initials": "S"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Pathogens", "issn": "2076-0817", "volume": "10", "issue": "5", "issn-l": "2076-0817"}, "abstract": "In this paper, we carried out a systematic literature review to document the emerging scientific knowledge about COVID-19 impact on livestock systems and food security in developing countries to identify gaps and possible avenues for future research undertakings. Specifically, we systematically reviewed 68 peer-reviewed articles extracted based on rigorous selection criteria from Scopus, PubMed and ISI Web of Science databases and published between December 2019 and February 2021. Our results reveal that livestock supply chains presented an important 'intermediary' pathway through which the pandemic affected various dimensions of food security in developing countries. Although the research response has been rapid in terms of both quantity and temporal succession, we find a highly suggestive disjunction in studies analyzing the interconnections between COVID-19 pandemic, livestock systems and food security in developing countries. With respect to the livestock supply chain, the bulk of the reviewed evidence focuses on production and consumption, whereas considerably less focus is given to the pandemic's impact on intermediaries within livestock chains, including traders, intermediaries and processors. The analysis of livestock supply chain resilience revolves predominantly around the 'absorbance' and 'recovery' phases of resilience, whereas only a small subset of the literature investigates actions taken by supply chain actors to 'plan' or to 'adapt' livestock systems in order to reduce their vulnerability and enhance their overall resilience. Furthermore, food security has often been narrowly defined, with the majority of articles focusing on 'availability' and 'accessibility' to food due to the pandemic, and other dimensions of food security, including utilization, stability and sustainability, have been widely neglected. Based on our findings, we recommend future research to examine the dynamics of propagation of COVID-19 impact through livestock supply chains in order to develop more targeted interventions that enhance the capacity of developing countries to cope with this and future disruptions and mitigate their food insecurity outcomes. To this end, more holistic, integrated and resilience-based approaches are much recommended to recognize the complex nature of livestock systems in developing countries and to address the multifaceted and widespread effects of COVID-19 on food security channeled through livestock chains.", "doi": "10.3390/pathogens10050586", "pmid": "34064749", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "pathogens10050586"}], "notes": [], "created": "2021-06-04T11:23:46.972Z", "modified": "2021-06-04T11:23:46.975Z"}, {"entity": "publication", "iuid": "79c11d5578e0406d9e0a6d1106918137", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79c11d5578e0406d9e0a6d1106918137.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79c11d5578e0406d9e0a6d1106918137"}}, "title": "Registered nurses' experiences of working in the intensive care unit during the COVID-19 pandemic.", "authors": [{"family": "Bergman", "given": "Lina", "initials": "L"}, {"family": "Falk", "given": "Ann-Charlotte", "initials": "A"}, {"family": "Wolf", "given": "Axel", "initials": "A"}, {"family": "Larsson", "given": "Ing-Marie", "initials": "I"}], "type": "journal article", "published": "2021-05-10", "journal": {"title": "Nurs Crit Care", "issn": "1478-5153", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "During the pandemic, increased numbers of patients requiring intensive care unit (ICU) admission required an increase in ICU capacity, including ICU staffing with competence to care for critically ill patients. Consequently, nurses from acute care areas were called in to staff the ICU along with experienced intensive care nurses.\r\n\r\nTo describe Swedish registered nurses' experiences of caring for patients with COVID-19 in ICUs during the pandemic.\r\n\r\nMixed method survey design.\r\n\r\nAn online questionnaire was distributed through social media to registered nurses who had been working in the ICU during the COVID-19 outbreak. Data were collected for 1 week (May 2020) and analysed using content analysis and descriptive statistics.\r\n\r\nOf the 282 nurses who participated, the majority were ICU nurses (n = 151; 54%). Half of the nurses specialized in ICU reported that they were responsible for the ICU care of three or more patients during the pandemic (n = 75; 50%). Among non-intensive care nurses, only 19% received introduction to the COVID-19 ICU (n = 26). The analysis of data regarding nurses' experiences resulted in three categories: tumbling into chaos, diminished nursing care, and transition into pandemic ICU care. Participants described how patient safety and care quality were compromised, and that nursing care was severely deprioritized during the pandemic. The situation of not being able to provide nursing care resulted in ethical stress. Furthermore, an increased workload and worsened work environment affected nurses' health and well-being.\r\n\r\nThe findings from the present study indicate that nurses perceived that patient safety and quality of care were compromised during the pandemic. This resulted in ethical stress among nurses, which may have affected their physical and psychosocial well-being.\r\n\r\nThe COVID-19 pandemic had a severe impact on nurses' work environment, which could result in burnout and staff turnover.", "doi": "10.1111/nicc.12649", "pmid": "33973304", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:52:32.250Z", "modified": "2021-07-14T08:47:44.764Z"}, {"entity": "publication", "iuid": "8ce37febe6f44ed1a369d9b92a59e015", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ce37febe6f44ed1a369d9b92a59e015.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ce37febe6f44ed1a369d9b92a59e015"}}, "title": "National Swedish survey showed that child health services and routine immunisation programmes were resilient during the early COVID-19 pandemic.", "authors": [{"family": "Falkenstein Hagander", "given": "Kathy", "initials": "K"}, {"family": "Aronsson", "given": "Bernice", "initials": "B"}, {"family": "Danielsson", "given": "Madelene", "initials": "M"}, {"family": "Lepp", "given": "Tiia", "initials": "T"}, {"family": "Kulane", "given": "Asli", "initials": "A"}, {"family": "Schollin Ask", "given": "Lina", "initials": "L"}], "type": "journal article", "published": "2021-05-10", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": null, "issue": null, "issn-l": "0803-5253"}, "abstract": "Routine immunisation programmes are at risk of disruption due to the COVID-19 pandemic. This study aimed to investigate the resilience of the Swedish national immunisation programme for children up to the age of five years during the early stages of the pandemic.\n\nThis was a cross-sectional, web-based survey of regional child health offices in Sweden between 10 September and 9 October 2020. It explored the organisation of child health services during the early stages of the pandemic, focusing on routine child immunisation.\n\nAll 21 Swedish regional child health offices responded. They stated that child immunisation had been prioritised, communication with families had been intensified and there was greater flexibility at all organisational levels of child health services. In addition, the vaccine supply was sustained and child health centres remained open. However, there were periodic staff shortages, increased numbers of health visits cancelled by parents and most parent-education groups were paused.\n\nThe Swedish immunisation programme was resilient during the early COVID-19 pandemic, thanks to sustainable organisation co-ordinated by Sweden's network of regional child health offices.", "doi": "10.1111/apa.15912", "pmid": "33973264", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:53:22.196Z", "modified": "2021-05-17T18:54:07.082Z"}, {"entity": "publication", "iuid": "2a8f278f7ff54f37ae4a00a474cf4625", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2a8f278f7ff54f37ae4a00a474cf4625.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2a8f278f7ff54f37ae4a00a474cf4625"}}, "title": "Health literacy and changes in pattern of drug use among participants at the Stockholm Needle Exchange Program during the COVID-19 pandemic.", "authors": [{"family": "Lindqvist", "given": "K", "initials": "K"}, {"family": "Wallmofeldt", "given": "C", "initials": "C"}, {"family": "Holm\u00e9n", "given": "E", "initials": "E"}, {"family": "Hammarberg", "given": "A", "initials": "A"}, {"family": "K\u00e5berg", "given": "M", "initials": "M"}], "type": "journal article", "published": "2021-05-10", "journal": {"title": "Harm Reduct J", "issn": "1477-7517", "issn-l": null, "volume": "18", "issue": "1", "pages": "52"}, "abstract": "People who inject drugs may be particularly vulnerable to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) due to underlying health problems, stigma and social vulnerabilities. Harm reduction services, including needle exchange programs (NEP), have been subjected to varying degrees of disruption in the world, especially in the beginning of the coronavirus disease 2019 (COVID-19) pandemic. Compared to responses in other countries, Sweden's initial strategy toward limiting the spread and impact of COVID-19 was less restrictive to its citizens with no imposed general societal lockdown. In this study, we investigate changes in drug use patterns, utilization of NEP associated health services, COVID-19 health literacy and the prevalence of SARS-CoV-2 antibodies among NEP clients in Stockholm during the COVID-19 pandemic.\r\n\r\nNEP visits and services provided (needles/syringes, HIV and hepatitis C tests and treatment, naloxone distributed) and overall mortality among NEP clients between January 1 and October 31, 2020, were used for trend analyses in comparison with corresponding 2019 data. Between July 27 and October 2, 2020, NEP clients (n = 232) responded to a 27 item COVID-19 Health Literacy Questionnaire. SARS CoV-2 IgG antibody tests (n = 779) were performed between June 15 and October 31, 2020.\r\n\r\nDuring the COVID-19 pandemic number of clients, client visits, naloxone distribution and HCV tests remained stable compared to 2019, while distribution of needles/syringes increased (p < 0.0001); number of HIV tests and HCV treatments decreased (p < 0.05); and mortality decreased (< 0.01). Overall, the level of health literacy concerning transmission routes and protective measures was high. SARS-CoV-2 antibody prevalence was 5.4% (95% CI 4.0-7.2).\r\n\r\nThe Stockholm NEP managed to maintain a high level of clients and services during the pandemic. In general, COVID-19 health literacy was adequate and the overall SARS-CoV-2 antibody prevalence was low compared to the general population, which highlights a need for prioritized and targeted COVID-19 vaccination among PWID.", "doi": "10.1186/s12954-021-00499-z", "pmid": "33971892", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12954-021-00499-z"}, {"db": "pmc", "key": "PMC8107802"}], "notes": [], "created": "2021-05-17T18:59:08.075Z", "modified": "2021-07-14T08:50:00.818Z"}, {"entity": "publication", "iuid": "039f7f7aa71844cb935de8f4a197c76d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/039f7f7aa71844cb935de8f4a197c76d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/039f7f7aa71844cb935de8f4a197c76d"}}, "title": "Determinants of SARS-CoV-2 Impacts on Small-Scale Commercial Broiler Production Systems in Egypt: Implications for Mitigation Strategies.", "authors": [{"family": "Abu Hatab", "given": "Assem", "initials": "A"}, {"family": "Liu", "given": "Zhen", "initials": "Z"}, {"family": "Nasser", "given": "Asmaa", "initials": "A"}, {"family": "Esmat", "given": "Abourehab", "initials": "A"}], "type": "journal article", "published": "2021-05-10", "journal": {"title": "Animals (Basel)", "issn": "2076-2615", "volume": "11", "issue": "5", "issn-l": null}, "abstract": "As in many other countries, the outbreak of the COVID-19 pandemic, together with subsequent government containment measures, posed significant challenges to small-scale broiler production systems in Egypt. Based on a survey of 205 specialist small-scale commercial broiler farms (SCBFs) consisting of both farm-based and household-based production systems, this study identifies the primary pathways through which COVID-19 has affected SCBFs and investigates the determinants of farm perception of these effects. A polychoric principal component analysis sorted the effects of the pandemic on the SCBFs surveyed into five categories, namely, input availability, production and operational costs, labor and human resources, consumer demand and sales, and farm finances. Next, five ordered logit models were constructed to examine the determinants of the SCBFs' perception of each category of these effects. Generally, the empirical results revealed that COVID-19 affected SCBFs heterogeneously based on their management and production systems and resource endowment. Female-led and household-based SCBFs perceived significantly greater COVID-19 effects. In contrast, individually owned farms and those with membership of poultry producer organizations and larger total asset values perceived fewer effects. In addition, SCBFs operating in both local and provincial markets were less likely to perceive negative effects from the pandemic on their broiler farming activities. Although the adoption of strict and immediate containment measures was essential for controlling the virus and protecting public health, our results indicate that policy responses to COVID-19 must consider the likely effects on small businesses such as SCBFs since disruptions to such socioeconomically important supply chains will intensify human suffering from the pandemic. Overall, our findings provide important implications for the formulation of effective strategies for mitigating the impact of COVID-19 on small-scale broiler production systems in Egypt and enhancing their preparedness and resilience to future pandemics, natural hazard risks, and market shocks.", "doi": "10.3390/ani11051354", "pmid": "34068757", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ani11051354"}], "notes": [], "created": "2021-06-04T11:18:36.120Z", "modified": "2021-06-04T11:18:36.144Z"}, {"entity": "publication", "iuid": "e808459a76314069ba46438ca769f8c3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e808459a76314069ba46438ca769f8c3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e808459a76314069ba46438ca769f8c3"}}, "title": "A simple cognitive task intervention to prevent intrusive memories after trauma in patients in the Emergency Department: A randomized controlled trial terminated due to COVID-19.", "authors": [{"family": "Kanstrup", "given": "Marie", "initials": "M"}, {"family": "Singh", "given": "Laura", "initials": "L"}, {"family": "G\u00f6ransson", "given": "Katarina E", "initials": "KE"}, {"family": "Gamble", "given": "Beau", "initials": "B"}, {"family": "Taylor", "given": "Rod S", "initials": "RS"}, {"family": "Iyadurai", "given": "Lalitha", "initials": "L"}, {"family": "Moulds", "given": "Michelle L", "initials": "ML"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}], "type": "journal article", "published": "2021-05-10", "journal": {"title": "BMC Res Notes", "issn": "1756-0500", "volume": "14", "issue": "1", "pages": "176", "issn-l": null}, "abstract": "This randomised controlled trial (RCT) aimed to investigate the effects of a simple cognitive task intervention on intrusive memories (\"flashbacks\") and associated symptoms following a traumatic event. Patients presenting to a Swedish emergency department (ED) soon after a traumatic event were randomly allocated (1:1) to the simple cognitive task intervention (memory cue + mental rotation instructions + computer game \"Tetris\" for at least 20 min) or control (podcast, similar time). We planned follow-ups at one-week, 1-month, and where possible, 3- and 6-months post-trauma. Anticipated enrolment was N = 148.\n\nThe RCT was terminated prematurely after recruiting N = 16 participants. The COVID-19 pandemic prevented recruitment/testing in the ED because: (i) the study required face-to-face contact between participants, psychology researchers, ED staff, and patients, incurring risk of virus transmission; (ii) the host ED site received COVID-19 patients; and (iii) reduced flow of patients otherwise presenting to the ED in non-pandemic conditions (e.g. after trauma). We report on delivery of study procedures, recruitment, treatment adherence, outcome completion (primary outcome: number of intrusive memories during week 5), attrition, and limitations. The information presented and limitations may enable our group and others to learn from this terminated study. Trial registration ClinicalTrials.gov: NCT04185155 (04-12-2019).", "doi": "10.1186/s13104-021-05572-1", "pmid": "33971951", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13104-021-05572-1"}, {"db": "pmc", "key": "PMC8107806"}, {"db": "ClinicalTrials.gov", "key": "NCT04185155"}], "notes": [], "created": "2021-05-17T18:58:33.047Z", "modified": "2021-05-17T18:58:33.070Z"}, {"entity": "publication", "iuid": "bf5f0fa24fcf48df934cf1cd3aaaeb64", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf5f0fa24fcf48df934cf1cd3aaaeb64.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf5f0fa24fcf48df934cf1cd3aaaeb64"}}, "title": "Reasons for physician-related variability in end-of-life decision-making in intensive care.", "authors": [{"family": "Nordenskj\u00f6ld Syrous", "given": "Alma", "initials": "A"}, {"family": "Malmgren", "given": "Johan", "initials": "J"}, {"family": "Odenstedt Herg\u00e8s", "given": "Helena", "initials": "H"}, {"family": "Olausson", "given": "Sepideh", "initials": "S"}, {"family": "Kock-Redfors", "given": "Maria", "initials": "M"}, {"family": "\u00c5g\u00e5rd", "given": "Anders", "initials": "A"}, {"family": "Block", "given": "Linda", "initials": "L"}], "type": "journal article", "published": "2021-05-08", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "volume": null, "issue": null, "issn-l": "0001-5172"}, "abstract": "There is increasing evidence that the individual physician is the main factor influencing variability in end-of-life decision-making in intensive care units. End-of-life decisions are complex and should be adapted to each patient. Physician-related variability is problematic as it may result in unequal assessments that affect patient outcomes. The primary aim of this study was to investigate factors contributing to physician-related variability in end-of-life decision-making.\n\nThis is a qualitative sub-study of a previously conducted study. In-depth thematic analysis of semi-structured interviews with 19 critical care specialists from five different Swedish intensive care units was performed. Interviews took place between February 1, 2017, and May 31, 2017.\n\nFactors influencing physician-related variability consisted of different assessment of patient preferences, as well as intensivists' personality and values. Personality was expressed mainly through pace and determination in the decision-making process. Personal prejudices appeared in decisions, but few respondents had personally witnessed this. Avoidance of criticism and conflicts as well as individual strategies for emotional coping were other factors that influenced physician-related variability. Many respondents feared criticism for making their assessments, and the challenging nature of end-of-life decision-making lead to avoidance as well as emotional stress.\n\nVariability in end-of-life decision-making is an important topic that needs further investigation. It is imperative that such variability be acknowledged and addressed in a more formal and transparent manner. The ethical issues faced by intensivists have recently been compounded by the devastating impact of the COVID-19 pandemic, demonstrating in profound terms the importance of the topic.", "doi": "10.1111/aas.13842", "pmid": "33964009", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-17T19:08:32.486Z", "modified": "2021-05-17T19:08:32.496Z"}, {"entity": "publication", "iuid": "bb47ae65f9ac4973b315454f08f44804", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb47ae65f9ac4973b315454f08f44804.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb47ae65f9ac4973b315454f08f44804"}}, "title": "Corrigendum to: The influence of the SARS-CoV-2 pandemic on esophagogastric cancer services: an international survey of esophagogastric surgeons.", "authors": [{"family": "Kamarajah", "given": "Sivesh K", "initials": "SK"}, {"family": "Markar", "given": "Sheraz R", "initials": "SR"}, {"family": "Singh", "given": "Pritam", "initials": "P"}, {"family": "Griffiths", "given": "Ewen A", "initials": "EA"}, {"family": "Oesophagogastric Anastomosis Audit Group", "given": "", "initials": ""}], "type": "published erratum", "published": "2021-05-08", "journal": {"title": "Dis Esophagus", "issn": "1442-2050", "volume": null, "issue": null, "issn-l": "1120-8694"}, "abstract": null, "doi": "10.1093/dote/doab035", "pmid": "33963749", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "6272293"}], "notes": [], "created": "2021-05-17T19:07:32.983Z", "modified": "2021-05-17T19:08:00.109Z"}, {"entity": "publication", "iuid": "0fc45db4f8184778a5ff2740cd42ec6b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0fc45db4f8184778a5ff2740cd42ec6b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0fc45db4f8184778a5ff2740cd42ec6b"}}, "title": "Tumor Treating Fields for Glioblastoma Therapy During the COVID-19 Pandemic.", "authors": [{"family": "Gatson", "given": "Na Tosha N", "initials": "NTN"}, {"family": "Barnholtz-Sloan", "given": "Jill", "initials": "J"}, {"family": "Drappatz", "given": "Jan", "initials": "J"}, {"family": "Henriksson", "given": "Roger", "initials": "R"}, {"family": "Hottinger", "given": "Andreas F", "initials": "AF"}, {"family": "Hinoul", "given": "Piet", "initials": "P"}, {"family": "Kruchko", "given": "Carol", "initials": "C"}, {"family": "Puduvalli", "given": "Vinay K", "initials": "VK"}, {"family": "Tran", "given": "David D", "initials": "DD"}, {"family": "Wong", "given": "Eric T", "initials": "ET"}, {"family": "Glas", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2021-05-07", "journal": {"title": "Front Oncol", "issn": "2234-943X", "volume": "11", "issue": null, "pages": "679702", "issn-l": null}, "abstract": "The COVID-19 pandemic has placed excessive strain on health care systems and is especially evident in treatment decision-making for cancer patients. Glioblastoma (GBM) patients are among the most vulnerable due to increased incidence in the elderly and the short survival time. A virtual meeting was convened on May 9, 2020 with a panel of neuro-oncology experts with experience using Tumor Treating Fields (TTFields). The objective was to assess the risk-to-benefit ratio and provide guidance for using TTFields in GBM during the COVID-19 pandemic.\n\nTopics discussed included support and delivery of TTFields during the COVID-19 pandemic, concomitant use of TTFields with chemotherapy, and any potential impact of TTFields on the immune system in an intrinsically immunosuppressed GBM population. Special consideration was given to TTFields' use in elderly patients and in combination with radiotherapy regimens. Finally, the panel discussed the need to better capture data on COVID-19positive brain tumor patients to analyze longitudinal outcomes and changes in treatment decision-making during the pandemic.\n\nTTFields is a portable home-use device which can be managed via telemedicine and safely used in GBM patients during the COVID-19 pandemic. TTFields has no known immunosuppressive effects which is important during a crisis where other treatment methods might be limited, especially for elderly patients with multiple co-morbidities. It is too early to estimate the full impact of COVID-19 on the global healthcare system and on patient outcomes and the panel strongly recommended collaboration with existing cancer COVID-19 registries to follow CNS tumor patients.", "doi": "10.3389/fonc.2021.679702", "pmid": "34026655", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8139188"}], "notes": [], "created": "2021-05-29T16:22:39.733Z", "modified": "2021-05-29T16:22:39.744Z"}, {"entity": "publication", "iuid": "cd5dcd1a8c0947f2aa56016df442cd57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd5dcd1a8c0947f2aa56016df442cd57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd5dcd1a8c0947f2aa56016df442cd57"}}, "title": "How mobility restrictions policy and atmospheric conditions impacted air quality in the State of S\u00e3o Paulo during the COVID-19 outbreak.", "authors": [{"family": "Rudke", "given": "A P", "initials": "AP"}, {"family": "Martins", "given": "J A", "initials": "JA"}, {"family": "de Almeida", "given": "D S", "initials": "DS"}, {"family": "Martins", "given": "L D", "initials": "LD"}, {"family": "Beal", "given": "A", "initials": "A"}, {"family": "Hallak", "given": "R", "initials": "R"}, {"family": "Freitas", "given": "E D", "initials": "ED"}, {"family": "Andrade", "given": "M F", "initials": "MF"}, {"family": "Foroutan", "given": "H", "initials": "H"}, {"family": "Baek", "given": "B H", "initials": "BH"}, {"family": "de A Albuquerque", "given": "T T", "initials": "TT"}], "type": "journal article", "published": "2021-05-07", "journal": {"title": "Environ Res", "issn": "1096-0953", "volume": null, "issue": null, "pages": "111255", "issn-l": "0013-9351"}, "abstract": "Mobility restrictions are among actions to prevent the spread of the COVID-19 pandemic and have been pointed as reasons for improving air quality, especially in large cities. However, it is crucial to assess the impact of atmospheric conditions on air quality and air pollutant dispersion in the face of the potential variability of all sources. In this study, the impact of mobility restrictions on the air quality was analyzed for the most populous Brazilian State, S\u00e3o Paulo, severely impacted by COVID-19. Ground-based air quality data (PM 10, PM2.5, CO, SO2, NOx, NO2, NO, and O3) were used from 50 automatic air quality monitoring stations to evaluate the changes in concentrations before (January 01 - March 25) and during the partial quarantine (March 16 - June 30). Rainfall, fires, and daily cell phone mobility data were also used as supplementary information to the analyses. The Mann-Whitney U test was used to assess the heterogeneity of the air quality data during and before mobility restrictions. In general, the results demonstrated no substantial improvements in air quality for most of the pollutants when comparing before and during restrictions periods. Besides, when the analyzed period of 2020 is compared with the year 2019, there is no significant air quality improvement in the S\u00e3o Paulo State. However, special attention should be given to the Metropolitan Area of S\u00e3o Paulo (MASP), due to the vast population residing in this area and exposed to air pollution. The region reached an average decrease of 29% in CO, 28% in NOx, 40% in NO, 19% in SO2, 15% in PM2.5, and 8% in PM10 concentrations during the mobility restrictions period compared to the same period in 2019. The only pollutant that showed an increase in concentration was ozone, with a 20% increase compared to 2019 during the mobility restrictions period. Before the mobility restrictions period, the region reached an average decrease of 30% in CO, 39% in NOx, 63% in NO, 12% in SO2, 23% in PM2.5, 18% in PM10, and 16% in O3 concentrations when compared to the same period in 2019. On the other hand, Cubat\u00e3o, a highly industrialized area, showed statistically significant increases above 20% for most monitored pollutants in both periods of 2020 compared to 2019. This study reinforces that the main driving force of pollutant concentration variability is the dynamics of the atmosphere at its various time scales. An abnormal rainy season, with above average rainfall before the restrictions and below average after it, generated a scenario in which the probable significant reductions in emissions did not substantially affect the concentration of pollutants.", "doi": "10.1016/j.envres.2021.111255", "pmid": "33971134", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0013-9351(21)00549-1"}], "notes": [], "created": "2021-05-17T19:01:41.083Z", "modified": "2021-05-17T19:01:41.093Z"}, {"entity": "publication", "iuid": "d549138e93274c768eeb439c799261d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d549138e93274c768eeb439c799261d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d549138e93274c768eeb439c799261d0"}}, "title": "The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity.", "authors": [{"family": "Osuchowski", "given": "Marcin F", "initials": "MF"}, {"family": "Winkler", "given": "Martin S", "initials": "MS"}, {"family": "Skirecki", "given": "Tomasz", "initials": "T"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "Shankar-Hari", "given": "Manu", "initials": "M"}, {"family": "Lachmann", "given": "Gunnar", "initials": "G"}, {"family": "Monneret", "given": "Guillaume", "initials": "G"}, {"family": "Venet", "given": "Fabienne", "initials": "F"}, {"family": "Bauer", "given": "Michael", "initials": "M"}, {"family": "Brunkhorst", "given": "Frank M", "initials": "FM"}, {"family": "Weis", "given": "Sebastian", "initials": "S"}, {"family": "Garcia-Salido", "given": "Alberto", "initials": "A"}, {"family": "Kox", "given": "Matthijs", "initials": "M"}, {"family": "Cavaillon", "given": "Jean-Marc", "initials": "J"}, {"family": "Uhle", "given": "Florian", "initials": "F"}, {"family": "Weigand", "given": "Markus A", "initials": "MA"}, {"family": "Floh\u00e9", "given": "Stefanie B", "initials": "SB"}, {"family": "Wiersinga", "given": "W Joost", "initials": "WJ"}, {"family": "Almansa", "given": "Raquel", "initials": "R"}, {"family": "de la Fuente", "given": "Amanda", "initials": "A"}, {"family": "Martin-Loeches", "given": "Ignacio", "initials": "I"}, {"family": "Meisel", "given": "Christian", "initials": "C"}, {"family": "Spinetti", "given": "Thibaud", "initials": "T"}, {"family": "Schefold", "given": "Joerg C", "initials": "JC"}, {"family": "Cilloniz", "given": "Catia", "initials": "C"}, {"family": "Torres", "given": "Antoni", "initials": "A"}, {"family": "Giamarellos-Bourboulis", "given": "Evangelos J", "initials": "EJ"}, {"family": "Ferrer", "given": "Ricard", "initials": "R"}, {"family": "Girardis", "given": "Massimo", "initials": "M"}, {"family": "Cossarizza", "given": "Andrea", "initials": "A"}, {"family": "Netea", "given": "Mihai G", "initials": "MG"}, {"family": "van der Poll", "given": "Tom", "initials": "T"}, {"family": "Bermejo-Mart\u00edn", "given": "Jes\u00fas F", "initials": "JF"}, {"family": "Rubio", "given": "Ignacio", "initials": "I"}], "type": "journal article", "published": "2021-05-06", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "issn-l": "2213-2600", "volume": null, "issue": null, "pages": null}, "abstract": "The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with devastating consequences. While the medical community has gained insight into the epidemiology of COVID-19, important questions remain about the clinical complexities and underlying mechanisms of disease phenotypes. Severe COVID-19 most commonly involves respiratory manifestations, although other systems are also affected, and acute disease is often followed by protracted complications. Such complex manifestations suggest that SARS-CoV-2 dysregulates the host response, triggering wide-ranging immuno-inflammatory, thrombotic, and parenchymal derangements. We review the intricacies of COVID-19 pathophysiology, its various phenotypes, and the anti-SARS-CoV-2 host response at the humoral and cellular levels. Some similarities exist between COVID-19 and respiratory failure of other origins, but evidence for many distinctive mechanistic features indicates that COVID-19 constitutes a new disease entity, with emerging data suggesting involvement of an endotheliopathy-centred pathophysiology. Further research, combining basic and clinical studies, is needed to advance understanding of pathophysiological mechanisms and to characterise immuno-inflammatory derangements across the range of phenotypes to enable optimum care for patients with COVID-19.", "doi": "10.1016/S2213-2600(21)00218-6", "pmid": "33965003", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(21)00218-6"}, {"db": "pmc", "key": "PMC8102044"}], "notes": [], "created": "2021-05-17T19:08:57.517Z", "modified": "2021-05-17T19:09:49.278Z"}, {"entity": "publication", "iuid": "60a03d4e003f4e54a08b1e41bde1fc2d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60a03d4e003f4e54a08b1e41bde1fc2d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60a03d4e003f4e54a08b1e41bde1fc2d"}}, "title": "Old Overnight: Experiences of Age-Based Recommendations in Response to the COVID-19 Pandemic in Sweden.", "authors": [{"family": "Nilsson", "given": "Gabriella", "initials": "G"}, {"family": "Ekstam", "given": "Lisa", "initials": "L"}, {"family": "Axmon", "given": "Anna", "initials": "A"}, {"family": "Andersson", "given": "Janicke", "initials": "J"}], "type": "journal article", "published": "2021-05-06", "journal": {"title": "J Aging Soc Policy", "issn": "1545-0821", "issn-l": null, "volume": null, "issue": null, "pages": "1-21"}, "abstract": "The Swedish response to the COVID-19 pandemic included age-based recommendations of voluntary quarantine specifically for those 70 years of age or older. This paper investigates the experiences of a sudden change of policy in the form of an age restriction that trumped the contemporary active aging ideal. A web-based qualitative survey was conducted in April 2020. Through manual coding of a total of 851 responses, six different ways of relating to the age-based recommendations were identified. The results show that age is not an unproblematic governing principle. Instead, in addition to protecting a vulnerable group, the age-based recommendation meant deprivation of previously assigned individual responsibility and, consequently, autonomy. It is shown how respondents handled this tension through varying degrees of compliance and resistance. Findings highlight the importance of continuously tracking the long-term consequences of age-based policy to avoid negative self-image and poorer health among older adults.", "doi": "10.1080/08959420.2021.1925042", "pmid": "34010122", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-05-20T14:37:14.738Z", "modified": "2021-07-14T08:26:56.251Z"}, {"entity": "publication", "iuid": "db3b2d224a54435bad4d993f3797ac03", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db3b2d224a54435bad4d993f3797ac03.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db3b2d224a54435bad4d993f3797ac03"}}, "title": "International transfers of personal data for health research following Schrems II: a problem in need of a solution.", "authors": [{"family": "Hallinan", "given": "Dara", "initials": "D"}, {"family": "Bernier", "given": "Alexander", "initials": "A"}, {"family": "Cambon-Thomsen", "given": "Anne", "initials": "A"}, {"family": "Crawley", "given": "Francis P", "initials": "FP"}, {"family": "Dimitrova", "given": "Diana", "initials": "D"}, {"family": "Medeiros", "given": "Claudia Bauzer", "initials": "CB"}, {"family": "Nilsonne", "given": "Gustav", "initials": "G"}, {"family": "Parker", "given": "Simon", "initials": "S"}, {"family": "Pickering", "given": "Brian", "initials": "B"}, {"family": "Rennes", "given": "St\u00e9phanie", "initials": "S"}], "type": "journal article", "published": "2021-05-06", "journal": {"title": "Eur J Hum Genet", "issn": "1476-5438", "volume": null, "issue": null, "issn-l": null}, "abstract": "On 16 July 2020, the Court of Justice of the European Union issued their decision in the Schrems II case concerning Facebook's transfers of personal data from the EU to the US. The decision may have significant effects on the legitimate transfer of personal data for health research purposes from the EU. This article aims: (i) to outline the consequences of the Schrems II decision for the sharing of personal data for health research between the EU and third countries, particularly in the context of the COVID-19 pandemic; and, (ii) to consider certain options available to address the consequences of the decision and to facilitate international data exchange for health research moving forward.", "doi": "10.1038/s41431-021-00893-y", "pmid": "33953344", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41431-021-00893-y"}, {"db": "pmc", "key": "PMC8099706"}], "notes": [], "created": "2021-05-17T19:04:18.502Z", "modified": "2021-05-17T19:04:35.741Z"}, {"entity": "publication", "iuid": "8afa2e52f9f84ccc9077e945af9211de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8afa2e52f9f84ccc9077e945af9211de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8afa2e52f9f84ccc9077e945af9211de"}}, "title": "Dying from COVID-19 in nursing homes-sex differences in symptom occurrence.", "authors": [{"family": "Martinsson", "given": "Lisa", "initials": "L"}, {"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "Bergstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Staffan", "initials": "S"}], "type": "journal article", "published": "2021-05-06", "journal": {"title": "BMC Geriatr", "issn": "1471-2318", "volume": "21", "issue": "1", "pages": "294", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19), is a disease with diverse presentation. Several studies have shown different occurrence of symptoms for women and men, but no studies have been found examining sex differences in clinical presentation for nursing home residents dying from COVID-19. The objective of this study was to describe sex and age differences and the impact of a dementia diagnosis on symptom occurrence during the last week in life for persons dying from COVID-19 in nursing homes.\n\nThis is a population-based retrospective study based on data from the Swedish Register of Palliative Care. A total of 1994 residents aged 65 or older who died from COVID-19 in nursing homes were identified. The impact of sex, age and a dementia diagnosis on six different symptoms was analysed using chi2-test and multivariate logistic regression.\n\nResidents dying from COVID-19 were more often men (p < .002). Men more often had dyspnoea and death rattles (p < .001). Nausea was more common in women (p < .001). No sex differences in the occurrence of pain, anxiety or confusion were seen. Dyspnoea and nausea were less commonly reported in residents with dementia (p < .001).\n\nWe found sex differences in symptom presentation for fatal COVID-19 in nursing home settings which remained after adjusting for age. Residents with a dementia diagnosis had fewer symptoms reported before death compared to those without dementia. Clinical presentation of fatal COVID-19 differs between women and men in nursing homes. Residents with fatal COVID-19 present with more unspecific and less prominent symptoms when also suffering from dementia.", "doi": "10.1186/s12877-021-02228-4", "pmid": "33957890", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12877-021-02228-4"}, {"db": "pmc", "key": "PMC8100361"}], "notes": [], "created": "2021-05-17T19:06:20.921Z", "modified": "2021-05-17T19:06:20.931Z"}, {"entity": "publication", "iuid": "935b8ada86fb4f158abf4c9e4ff4e452", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/935b8ada86fb4f158abf4c9e4ff4e452.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/935b8ada86fb4f158abf4c9e4ff4e452"}}, "title": "Comparison of Immunological Profiles of SARS-CoV-2 Variants in the COVID-19 Pandemic Trends: An Immunoinformatics Approach.", "authors": [{"family": "Mallavarpu Ambrose", "given": "Jenifer", "initials": "J"}, {"family": "Priya Veeraraghavan", "given": "Vishnu", "initials": "V"}, {"family": "Kullappan", "given": "Malathi", "initials": "M"}, {"family": "Chellapandiyan", "given": "Poongodi", "initials": "P"}, {"family": "Krishna Mohan", "given": "Surapaneni", "initials": "S"}, {"family": "Manivel", "given": "Vivek Anand", "initials": "VA"}], "type": "journal article", "published": "2021-05-06", "journal": {"title": "Antibiotics (Basel)", "issn": "2079-6382", "volume": "10", "issue": "5", "issn-l": null}, "abstract": "The current dynamics of the COVID-19 pandemic have become a serious concern with the emergence of a series of mutant variants of the SARS-CoV-2 virus. Unlike the previous strain, it is reported that the descendants are associated with increased risk of transmission yet causing less impact in terms of hospital admission, the severity of illness, or mortality. Moreover, the vaccine efficacy is also not believed to vary among the population depending on the variants of the virus and ethnicity. It has been determined that the mutations recorded in the spike gene and protein of the newly evolved viruses are specificallyresponsible for this transformation in the behavior of the virus and its disease condition. Hence, this study aimed to compare the immunogenic profiles of the spike protein from the latest variants of the SARS-CoV-2 virus concerning the probability of COVID-19 severity. Genome sequences of the latest SARS-CoV-2 variants were obtained from GISAID and NCBI repositories. The translated protein sequences were run against T-cell and B-cell epitope prediction tools. Subsequently, antigenicity, immunogenicity, allergenicity, toxicity, and conservancy of the identified epitopes were ascertained using various prediction servers. Only the non-allergic and non-toxic potential epitopes were matched for population relevance by using the Human Leucocyte Antigen population registry in IEDB. Finally, the selected epitopes were validated by docking and simulation studies. The evaluated immunological parameters would concurrently reveal the severity of COVID-19, determining the infection rate of the pathogen. Our immunoinformatics approach disclosed that spike protein of the five variants was capable of forming potential T and B-cell epitopes with varying immune responses. Although the Wuhan strain showed a high number of epitope/HLA combinations, relatively less antigenicity and higher immunogenicity results in poor neutralizing capacity, which could be associated with increased disease severity. Our data demonstrate that increased viral antigenicity with moderate to high immunogenicity, and several potential epitope/HLA combinations in England strain, the USA, India, and South Africa variants, could possess a high neutralizing ability. Therefore, our findings reinforce that the newly circulating variants of SARS-CoV-2 might be associated with more infectiousness and less severe disease condition despite their greater viremia, as reported in the recent COVID-19 cases, whichconsequently determine their increased epidemiological fitness.", "doi": "10.3390/antibiotics10050535", "pmid": "34066389", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "antibiotics10050535"}], "notes": [], "created": "2021-06-04T11:21:05.121Z", "modified": "2021-06-04T11:21:21.712Z"}, {"entity": "publication", "iuid": "8ffd2261bef943428c8755ef205b6cb9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ffd2261bef943428c8755ef205b6cb9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ffd2261bef943428c8755ef205b6cb9"}}, "title": "Assessing the consequences of quarantines during a pandemic.", "authors": [{"family": "Forslid", "given": "Rikard", "initials": "R"}, {"family": "Herzing", "given": "Mathias", "initials": "M"}], "type": "journal article", "published": "2021-05-06", "journal": {"title": "Eur J Health Econ", "issn": "1618-7601", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "This paper analyzes the epidemiological and economic effects of quarantines. We use a basic epidemiological model, a SEIR-model, that is calibrated to roughly resemble the COVID-19 pandemic, and we assume that individuals that become infected or are isolated on average lose a share of their productivity. An early quarantine postpones but does not alter the course of the pandemic at a cost that increases in the duration and the extent of the quarantine. For quarantines at later stages of the pandemic there is a trade-off between lowering the peak level of infectious people on the one hand and minimizing fatalities and economic losses on the other hand. A longer quarantine dampens the peak level of infectious people and also reduces the total number of infected persons but increases economic losses. Both the peak level of infectious individuals and the total share of the population that will have been infected are U-shaped in relation to the share of the population in quarantine, while economic costs increase in this share. In particular, a quarantine covering a moderate share of the population leads to a lower peak, fewer deaths and lower economic costs, but it implies that the peak of the pandemic occurs earlier.", "doi": "10.1007/s10198-021-01310-3", "pmid": "33956249", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10198-021-01310-3"}, {"db": "pmc", "key": "PMC8100945"}], "notes": [], "created": "2021-05-17T19:04:55.024Z", "modified": "2021-07-14T08:24:40.283Z"}, {"entity": "publication", "iuid": "3794415570724752b202ae478473faa3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3794415570724752b202ae478473faa3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3794415570724752b202ae478473faa3"}}, "title": "Microvascular Dysfunction in Patients with Critical COVID-19, A Pilot Study.", "authors": [{"family": "Tehrani", "given": "Sara", "initials": "S"}, {"family": "Gille-Johnson", "given": "Patrik", "initials": "P"}], "type": "journal article", "published": "2021-05-04", "journal": {"title": "Shock", "issn": "1540-0514", "volume": null, "issue": null, "issn-l": null}, "abstract": "Endothelial and microvascular dysfunction may be a key pathogenic feature of severe COVID-19. The aim of this study was to investigate endothelial-dependent and endothelial-independent skin microvascular reactivity in patients with critical COVID-19.\n\nTwelve patients with COVID-19 treated with non-invasive or invasive mechanical ventilation were included in the study. We investigated skin microvascular reactivity on two separate days during hospitalization (study day 1 and 2) and at least three months after disease onset (study day 3). Twelve controls with no confirmed or suspected COVID-19 infection during 2020 were also examined. Skin perfusion was investigated through Laser Speckle Contrast Imaging (LSCI) before and after iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP) to determine the endothelial-dependent and the endothelial-independent vasodilation, respectively.\n\nCompared to controls, patients with critical COVID-19 had higher basal skin perfusion and reduced responses to endothelial-dependent (ACh, p = 0.002) and endothelial-independent (SNP, p = 0.01) vasodilator drugs on study day 1. In addition, the ACh/SNP ratio was significantly reduced in patients (0.50 \u00b1 0.36 versus 0.91 \u00b1 0.49 in controls, p = 0.02). Three months after disease onset, surviving patients tended to have reduced ACh-mediated vasodilation compared to controls (p = 0.08).\n\nThis small-sized pilot study demonstrates that critical COVID-19 infection is associated with microvascular impairment and, in particular, a markedly reduced endothelial function. Our results also suggest that microvascular function may not be fully recovered three months after disease onset.", "doi": "10.1097/SHK.0000000000001803", "pmid": "33958544", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00024382-900000000-97251"}], "notes": [], "created": "2021-05-17T19:06:47.746Z", "modified": "2021-05-17T19:06:47.768Z"}, {"entity": "publication", "iuid": "449ea5b1c2084fbeb52732384922e8cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/449ea5b1c2084fbeb52732384922e8cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/449ea5b1c2084fbeb52732384922e8cb"}}, "title": "Hairy cell leukemia and COVID-19 adaptation of treatment guidelines.", "authors": [{"family": "Grever", "given": "Michael", "initials": "M"}, {"family": "Andritsos", "given": "Leslie", "initials": "L"}, {"family": "Banerji", "given": "Versha", "initials": "V"}, {"family": "Barrientos", "given": "Jacqueline C", "initials": "JC"}, {"family": "Bhat", "given": "Seema", "initials": "S"}, {"family": "Blachly", "given": "James S", "initials": "JS"}, {"family": "Call", "given": "Timothy", "initials": "T"}, {"family": "Cross", "given": "Matthew", "initials": "M"}, {"family": "Dearden", "given": "Claire", "initials": "C"}, {"family": "Demeter", "given": "Judit", "initials": "J"}, {"family": "Dietrich", "given": "Sasha", "initials": "S"}, {"family": "Falini", "given": "Brunangelo", "initials": "B"}, {"family": "Forconi", "given": "Francesco", "initials": "F"}, {"family": "Gladstone", "given": "Douglas E", "initials": "DE"}, {"family": "Gozzetti", "given": "Alessandro", "initials": "A"}, {"family": "Iyengar", "given": "Sunil", "initials": "S"}, {"family": "Johnston", "given": "James B", "initials": "JB"}, {"family": "Juliusson", "given": "Gunnar", "initials": "G"}, {"family": "Kraut", "given": "Eric", "initials": "E"}, {"family": "Kreitman", "given": "Robert J", "initials": "RJ"}, {"family": "Lauria", "given": "Francesco", "initials": "F"}, {"family": "Lozanski", "given": "Gerard", "initials": "G"}, {"family": "Parikh", "given": "Sameer A", "initials": "SA"}, {"family": "Park", "given": "Jae", "initials": "J"}, {"family": "Polliack", "given": "Aaron", "initials": "A"}, {"family": "Ravandi", "given": "Farhad", "initials": "F"}, {"family": "Robak", "given": "Tadeusz", "initials": "T"}, {"family": "Rogers", "given": "Kerry A", "initials": "KA"}, {"family": "Saven", "given": "Alan", "initials": "A"}, {"family": "Seymour", "given": "John F", "initials": "JF"}, {"family": "Tadmor", "given": "Tamar", "initials": "T"}, {"family": "Tallman", "given": "Martin S", "initials": "MS"}, {"family": "Tam", "given": "Constantine S", "initials": "CS"}, {"family": "Tiacci", "given": "Enrico", "initials": "E"}, {"family": "Troussard", "given": "Xavier", "initials": "X"}, {"family": "Zent", "given": "Clive", "initials": "C"}, {"family": "Zenz", "given": "Thorsten", "initials": "T"}, {"family": "Zinzani", "given": "Pier Luigi", "initials": "PL"}, {"family": "W\u00f6rmann", "given": "Bernhard", "initials": "B"}], "type": "journal article", "published": "2021-05-04", "journal": {"title": "Leukemia", "issn": "1476-5551", "volume": null, "issue": null, "issn-l": null}, "abstract": "Standard treatment options in classic HCL (cHCL) result in high response rates and near normal life expectancy. However, the disease itself and the recommended standard treatment are associated with profound and prolonged immunosuppression, increasing susceptibility to infections and the risk for a severe course of COVID-19. The Hairy Cell Leukemia Foundation (HCLF) has recently convened experts and discussed different clinical strategies for the management of these patients. The new recommendations adapt the 2017 consensus for the diagnosis and management with cHCL to the current COVID-19 pandemic. They underline the option of active surveillance in patients with low but stable blood counts, consider the use of targeted and non-immunosuppressive agents as first-line treatment for cHCL, and give recommendations on preventive measures against COVID-19.", "doi": "10.1038/s41375-021-01257-7", "pmid": "33947938", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41375-021-01257-7"}], "notes": [], "created": "2021-05-06T05:52:53.609Z", "modified": "2021-05-06T05:52:53.635Z"}, {"entity": "publication", "iuid": "c60e9460c17a4c23a2bc424aa1029baa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c60e9460c17a4c23a2bc424aa1029baa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c60e9460c17a4c23a2bc424aa1029baa"}}, "title": "Multi-omics reveals age-related differences in the diaphragm response to mechanical ventilation: a pilot study.", "authors": [{"family": "Lyu", "given": "Qiong", "initials": "Q"}, {"family": "Wen", "given": "Ya", "initials": "Y"}, {"family": "Zhang", "given": "Xiang", "initials": "X"}, {"family": "Addinsall", "given": "Alex B", "initials": "AB"}, {"family": "Cacciani", "given": "Nicola", "initials": "N"}, {"family": "Larsson", "given": "Lars", "initials": "L", "orcid": "0000-0003-3722-035X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5f02065531945db928529767189a083.json"}}], "type": "comparative study", "published": "2021-05-03", "journal": {"title": "Skeletal Muscle", "issn": "2044-5040", "issn-l": null, "volume": "11", "issue": "1", "pages": "11"}, "abstract": "Old age is associated with a significantly increased mortality in COVID-19 patients exposed to long-term controlled mechanical ventilation (CMV) and suggested to be due to the hyperinflammatory response associated with the viral infection. However, our understanding of age-related differences in the response to CMV in the absence of a viral infection remains insufficient.\n\nYoung (7-8 months) and old (28-32 months) F344 BN hybrid rats were exposed to the ICU condition for 5 days, i.e., complete immobilization, mechanical ventilation, and extensive monitoring. Transcriptomic (RNA-Seq) and proteomics (Proximity Extension Assay) analyses of the diaphragm and proteomics analysis of plasma were conducted to investigate the molecular differences between young and old rats exposed to the ICU condition.\n\nAccording to multi-omics analyses, significant differences were observed in the diaphragm between young and old rats in response to 5 days CMV and immobilization. In young rats, metabolic pathways were primarily downregulated in response to immobilization (post-synaptic blockade of neuromuscular transmission). In old rats, on the other hand, dramatic immune and inflammatory responses were observed, i.e., an upregulation of specific related pathways such as \"IL-17 signaling pathway\", along with a higher level of inflammatory factors and cytokine/chemokine in plasma.\n\nThe dramatically increased mortality in old ICU patients with COVID-19-associated hyperinflammation and cytokine storm need not only reflect the viral infection but may also be associated with the ventilator induced diaphragm dysfunction (VIDD) and hyperinflammatory responses induced by long-term CMV per se. Although mechanical ventilation is a life-saving intervention in COVID-19 ICU patients, CMV should be cautiously used especially in old age and other means of respiratory support may be considered, such as negative pressure ventilation.", "doi": "10.1186/s13395-021-00267-4", "pmid": "33941271", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13395-021-00267-4"}, {"db": "pmc", "key": "PMC8089133"}], "notes": [], "created": "2021-05-04T15:55:44.955Z", "modified": "2021-06-10T11:24:48.982Z"}, {"entity": "publication", "iuid": "d1f06bd2922e4bbbbedc6a1fd11f2401", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1f06bd2922e4bbbbedc6a1fd11f2401.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1f06bd2922e4bbbbedc6a1fd11f2401"}}, "title": "Knowledge and preventive behaviors regarding COVID-19 in Bangladesh: A nationwide distribution", "authors": [{"family": "Hosen", "given": "Ismail", "initials": "I"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Sakib", "given": "Najmuj", "initials": "N"}, {"family": "Hussain", "given": "Nur", "initials": "N"}, {"family": "al Mamun", "given": "Firoj", "initials": "F"}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA"}], "type": "journal-article", "published": "2021-05-03", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "5", "pages": "e0251151"}, "abstract": null, "doi": "10.1371/journal.pone.0251151", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.7910/DVN/YKH9C1", "description": "Dataset: socio-demographic characteristics,  sources from where participants get information regarding COVID-19, participants\u2019 knowledge concerning COVID-19, participants\u2019 behavior in preventing COVID-19 etc."}], "notes": [], "created": "2021-05-04T15:56:57.740Z", "modified": "2021-07-14T08:38:09.031Z"}, {"entity": "publication", "iuid": "8cdc3bccc3c8411e8e40b47d294ea43a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8cdc3bccc3c8411e8e40b47d294ea43a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8cdc3bccc3c8411e8e40b47d294ea43a"}}, "title": "False Positive Results in SARS-CoV-2 Serological Tests for Samples From Patients With Chronic Inflammatory Diseases", "authors": [{"family": "Kharlamova", "given": "Nastya", "initials": "N"}, {"family": "Dunn", "given": "Nicky", "initials": "N"}, {"family": "Bedri", "given": "Sahl K", "initials": "SK"}, {"family": "Jerling", "given": "Svante", "initials": "S"}, {"family": "Almgren", "given": "Malin", "initials": "M"}, {"family": "Faustini", "given": "Francesca", "initials": "F"}, {"family": "Gunnarsson", "given": "Iva", "initials": "I"}, {"family": "R\u00f6nnelid", "given": "Johan", "initials": "J"}, {"family": "Pullerits", "given": "Rille", "initials": "R"}, {"family": "Gjertsson", "given": "Inger", "initials": "I"}, {"family": "Lundberg", "given": "Karin", "initials": "K"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Fink", "given": "Katharina", "initials": "K"}, {"family": "Fogdell-Hahn", "given": "Anna", "initials": "A"}], "type": "journal-article", "published": "2021-05-03", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "12", "issue": null, "pages": "666114"}, "abstract": "Patients with chronic inflammatory diseases are often treated with immunosuppressants and therefore are of particular concern during the SARS-CoV-2 pandemic. Serological tests will improve our understanding of the infection and immunity in this population, unless they tests give false positive results. The aim of this study was to evaluate the specificity of SARS-Cov-2 serological assays using samples from patients with chronic inflammatory diseases collected prior to April 2019, thus defined as negative. Samples from patients with multiple sclerosis (MS, n=10), rheumatoid arthritis (RA, n=47) with or without rheumatoid factor (RF) and/or anti-cyclic citrullinated peptide antibodies (anti-CCP2) and systemic lupus erythematosus (SLE, n=10) with or without RF, were analyzed for SARS-CoV-2 antibodies using 17 commercially available lateral flow assays (LFA), two ELISA kits and one in-house developed IgG multiplex bead-based assay. Six LFA and the in-house validated IgG assay correctly produced negative results for all samples. However, the majority of assays (n=13), gave false positive signal for samples from patients with RA and SLE. This was most notable in samples from RF positive RA patients. No false positive samples were detected in any assay using samples from patients with MS. Poor specificity of commercial serological assays could possibly be, at least partly, due to interfering antibodies in samples from patients with chronic inflammatory diseases. For these patients, the risk of false positivity should be considered when interpreting results of the SARS-CoV-2 serological assays.", "doi": "10.3389/fimmu.2021.666114", "pmid": "34012450", "labels": {"Type: Journal article": null, "Funder: Vinnova": null, "Category: Serology": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8126683"}, {"db": "URL", "key": "https://doi.org/10.3389/fimmu.2021.666114.s001", "description": "False Positive Results in SARS-CoV-2 Serological Tests for Samples From Patients With Chronic Inflammatory Diseases"}], "notes": [], "created": "2021-05-21T17:22:04.614Z", "modified": "2021-11-19T11:29:29.703Z"}, {"entity": "publication", "iuid": "9f36b274935a454b82985f1686c1cf90", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f36b274935a454b82985f1686c1cf90.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f36b274935a454b82985f1686c1cf90"}}, "title": "COVID-19 and ANCA-associated vasculitis \u2013 recommendations for vaccine preparedness and the use of rituximab", "authors": [{"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Alberici", "given": "Federico", "initials": "F"}, {"family": "Fervenza", "given": "Fernando C", "initials": "FC"}, {"family": "Jayne", "given": "David R W", "initials": "DRW"}, {"family": "Segelmark", "given": "M\u00e5rten", "initials": "M"}, {"family": "Tesar", "given": "Vladimir", "initials": "V"}, {"family": "Szpirt", "given": "Wladimir M", "initials": "WM"}], "type": "journal-article", "published": "2021-05-03", "journal": {"title": "Nephrol Dial Transplant", "issn": "0931-0509", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1093/ndt/gfab174", "pmid": null, "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-05T05:25:35.500Z", "modified": "2021-05-05T05:25:35.513Z"}, {"entity": "publication", "iuid": "1dd2c1d420b74b8c96ee17f2ba351e6c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1dd2c1d420b74b8c96ee17f2ba351e6c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1dd2c1d420b74b8c96ee17f2ba351e6c"}}, "title": "A urinary peptidomic profile predicts outcome in SARS-CoV-2-infected patients.", "authors": [{"family": "Wendt", "given": "Ralph", "initials": "R"}, {"family": "Thijs", "given": "Lutgarde", "initials": "L"}, {"family": "Kalbitz", "given": "Sven", "initials": "S"}, {"family": "Mischak", "given": "Harald", "initials": "H"}, {"family": "Siwy", "given": "Justyna", "initials": "J"}, {"family": "Raad", "given": "Julia", "initials": "J"}, {"family": "Metzger", "given": "Jochen", "initials": "J"}, {"family": "Neuhaus", "given": "Barbara", "initials": "B"}, {"family": "Leyen", "given": "Heiko von der", "initials": "HV"}, {"family": "Dudoignon", "given": "Emmanuel", "initials": "E"}, {"family": "Mebazaa", "given": "Alexandre", "initials": "A"}, {"family": "Spasovski", "given": "Goce", "initials": "G"}, {"family": "Milenkova", "given": "Mimoza", "initials": "M"}, {"family": "Canevska-Talevska", "given": "Aleksandra", "initials": "A"}, {"family": "Czerwie\u0144ska", "given": "Beata", "initials": "B"}, {"family": "Wiecek", "given": "Andrzej", "initials": "A"}, {"family": "Peters", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Nilsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Schwab", "given": "Matthias", "initials": "M"}, {"family": "Rothfuss", "given": "Katja", "initials": "K"}, {"family": "L\u00fcbbert", "given": "Christoph", "initials": "C"}, {"family": "Staessen", "given": "Jan A", "initials": "JA"}, {"family": "Beige", "given": "Joachim", "initials": "J"}, {"family": "CRIT-COV-U investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-03", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": null, "issue": null, "pages": "100883", "issn-l": null}, "abstract": "COVID-19 prediction models based on clinical characteristics, routine biochemistry and imaging, have been developed, but little is known on proteomic markers reflecting the molecular pathophysiology of disease progression.\n\nhe multicentre (six European study sites) Prospective Validation of a Proteomic Urine Test for Early and Accurate Prognosis of Critical Course Complications in Patients with SARS-CoV-2 Infection Study (Crit-COV-U) is recruiting consecutive patients (\u2265 18 years) with PCR-confirmed SARS-CoV-2 infection. A urinary proteomic biomarker (COV50) developed by capillary-electrophoresis-mass spectrometry (CE-MS) technology, comprising 50 sequenced peptides and identifying the parental proteins, was evaluated in 228 patients (derivation cohort) with replication in 99 patients (validation cohort). Death and progression along the World Health Organization (WHO) Clinical Progression Scale were assessed up to 21 days after the initial PCR test. Statistical methods included logistic regression, receiver operating curve (ROC) analysis and comparison of the area under the curve (AUC).\n\nin the derivation cohort, 23 patients died, and 48 developed worse WHO scores. The odds ratios (OR) for death per 1 standard deviation (SD) increment in COV50 were 3\u00b752 (95% CI, 2\u00b702-6\u00b713, p <0\u00b70001) unadjusted and 2\u00b773 (1\u00b725-5\u00b795, p = 0\u00b7012) adjusted for sex, age, baseline WHO score, body mass index (BMI) and comorbidities. For WHO scale progression, the corresponding OR were 2\u00b763 (1\u00b780-3\u00b785, p<0\u00b70001) and 3\u00b738 (1\u00b785-6\u00b717, p<0\u00b70001), respectively. The area under the curve (AUC) for COV50 as a continuously distributed variable was 0\u00b780 (0\u00b772-0\u00b788) for mortality and 0\u00b774 (0\u00b766-0\u00b781) for worsening WHO score. The optimised COV50 thresholds for mortality and worsening WHO score were 0\u00b747 and 0\u00b704 with sensitivity/specificity of 87\u00b70 (74\u00b76%) and 77\u00b71 (63\u00b79%), respectively. On top of covariates, COV50 improved the AUC, albeit borderline for death, from 0\u00b778 to 0\u00b782 (p = 0\u00b711) and 0\u00b784 (p = 0\u00b7052) for mortality and from 0\u00b768 to 0\u00b778 (p = 0\u00b70097) and 0\u00b775 (p = 0\u00b7021) for worsening WHO score. The validation cohort findings were confirmatory.\n\nthis first CRIT-COV-U report proves the concept that urinary proteomic profiling generates biomarkers indicating adverse COVID-19 outcomes, even at an early disease stage, including WHO stages 1-3. These findings need to be consolidated in an upcoming final dataset.", "doi": "10.1016/j.eclinm.2021.100883", "pmid": "33969282", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(21)00163-2"}, {"db": "pmc", "key": "PMC8092440"}], "notes": [], "created": "2021-05-17T18:39:24.579Z", "modified": "2021-05-17T19:02:55.993Z"}, {"entity": "publication", "iuid": "f7ab08cba0a74716b976aaa57be82009", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7ab08cba0a74716b976aaa57be82009.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7ab08cba0a74716b976aaa57be82009"}}, "title": "Recent advances on smart glycoconjugate vaccines in infections and cancer.", "authors": [{"family": "Anderluh", "given": "Marko", "initials": "M"}, {"family": "Berti", "given": "Francesco", "initials": "F"}, {"family": "Bzducha-Wr\u00f3bel", "given": "Anna", "initials": "A"}, {"family": "Chiodo", "given": "Fabrizio", "initials": "F"}, {"family": "Colombo", "given": "Cinzia", "initials": "C"}, {"family": "Compostella", "given": "Federica", "initials": "F"}, {"family": "Durlik", "given": "Katarzyna", "initials": "K"}, {"family": "Ferhati", "given": "Xhenti", "initials": "X"}, {"family": "Holmdahl", "given": "Rikard", "initials": "R"}, {"family": "Jovanovic", "given": "Dragana", "initials": "D"}, {"family": "Kaca", "given": "Wieslaw", "initials": "W"}, {"family": "Lay", "given": "Luigi", "initials": "L"}, {"family": "Marinovic-Cincovic", "given": "Milena", "initials": "M"}, {"family": "Marradi", "given": "Marco", "initials": "M"}, {"family": "Ozil", "given": "Musa", "initials": "M"}, {"family": "Polito", "given": "Laura", "initials": "L"}, {"family": "Reina", "given": "Jos\u00e8 Juan", "initials": "JJ"}, {"family": "Reis", "given": "Celso A", "initials": "CA"}, {"family": "Sackstein", "given": "Robert", "initials": "R"}, {"family": "Silipo", "given": "Alba", "initials": "A"}, {"family": "\u0160vajger", "given": "Urban", "initials": "U"}, {"family": "Van\u011bk", "given": "Ond\u0159ej", "initials": "O"}, {"family": "Yamamoto", "given": "Fumiichiro", "initials": "F"}, {"family": "Richichi", "given": "Barbara", "initials": "B"}, {"family": "van Vliet", "given": "Sandra J", "initials": "SJ"}], "type": "journal article", "published": "2021-05-02", "journal": {"title": "FEBS J", "issn": "1742-4658", "volume": null, "issue": null, "issn-l": null}, "abstract": "Vaccination is one of the greatest achievements in biomedical research preventing death and morbidity in many infectious diseases through the induction of pathogen-specific humoral and cellular immune responses. Currently, no effective vaccines are available for pathogens with a highly variable antigenic load, such as the Human Immunodeficiency Virus or to induce cellular T cell immunity in the fight against cancer. The recent SARS-CoV-2 outbreak has reinforced the relevance of designing smart therapeutic vaccine modalities to ensure public health. Indeed, academic and private companies have ongoing joint efforts to develop novel vaccine prototypes for this virus. Many pathogens are covered by a dense glycan-coat, which form an attractive target for vaccine development. Moreover, many tumor types are characterized by altered glycosylation profiles that are known as 'tumor-associated carbohydrate antigens' (TACA). Unfortunately, glycans do not provoke a vigorous immune response and generally serve as T cell-independent antigens, not eliciting protective IgG responses nor inducing immunological memory. A close and continuous crosstalk between glycochemists and glycoimmunologists is essential for the successful development of efficient immune modulators. It is clear that this is a key point for the discovery of novel approaches, which could significantly improve our understanding of the immune system. In this review, we discuss the latest advancements in development of vaccines against glycan epitopes to gain selective immune responses, and to provide an overview on the role of different immunogenic constructs in improving glycovaccine efficacy.", "doi": "10.1111/febs.15909", "pmid": "33934527", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-05-04T16:00:22.998Z", "modified": "2021-05-04T16:00:37.238Z"}, {"entity": "publication", "iuid": "72366a5fda114992bd1bbdfa17219211", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/72366a5fda114992bd1bbdfa17219211.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/72366a5fda114992bd1bbdfa17219211"}}, "title": "Hypercoagulation detected by Rotational Thromboelastometry predicts mortality in COVID-19: A risk model based on a prospective observational study.", "authors": [{"family": "Almskog", "given": "Lou M", "initials": "LM"}, {"family": "Wikman", "given": "Agneta", "initials": "A"}, {"family": "Svensson", "given": "Jonas", "initials": "J"}, {"family": "Bottai", "given": "Matteo", "initials": "M"}, {"family": "Kotorman", "given": "Mariann", "initials": "M"}, {"family": "Wahlgren", "given": "Carl Magnus", "initials": "CM"}, {"family": "Wanecek", "given": "Michael", "initials": "M"}, {"family": "van der Linden", "given": "Jan", "initials": "J"}, {"family": "Agren", "given": "Anna", "initials": "A"}], "type": "posted-content", "published": "2021-05-02", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.29.21256241", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-06T05:55:09.580Z", "modified": "2021-05-29T16:36:11.743Z"}, {"entity": "publication", "iuid": "63be2794a8004e448f9fdca621b953b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63be2794a8004e448f9fdca621b953b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63be2794a8004e448f9fdca621b953b0"}}, "title": "Aspirin and NSAID use and the risk of COVID-19", "authors": [{"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Guo", "given": "Chuan Guo", "initials": "CG"}, {"family": "Lee", "given": "Karla A", "initials": "KA"}, {"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Lo", "given": "Chun Han", "initials": "CH"}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Mehta", "given": "Raaj S", "initials": "RS"}, {"family": "Kwon", "given": "Sohee", "initials": "S"}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Song", "given": "Mingyang", "initials": "M"}, {"family": "Davies", "given": "Richard", "initials": "R"}, {"family": "Capdevila", "given": "Joan", "initials": "J"}, {"family": "Lochlainn", "given": "Mary Ni", "initials": "MN"}, {"family": "Sudre", "given": "Carole H", "initials": "CH", "orcid": "0000-0001-5753-428X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c26472813fed4007a8757af771de1802.json"}}, {"family": "Graham", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-4170-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f5f4e19812a46ed9e873732ec25e28d.json"}}, {"family": "Varsavsky", "given": "Thomas", "initials": "T"}, {"family": "Gomez", "given": "Maria F", "initials": "MF"}, {"family": "Kennedy", "given": "Beatrice", "initials": "B"}, {"family": "Fitipaldi", "given": "Hugo", "initials": "H"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Spector", "given": "Tim D", "initials": "TD"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S", "orcid": "0000-0002-5694-5340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74c7b9b1633144879042d198c7205656.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}], "type": "posted-content", "published": "2021-05-02", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.28.21256261", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "Health data research innovation gateway", "key": "https://healthdatagateway.org/detail/9b604483-9cdc-41b2-b82c-14ee3dd705f6", "description": "Anonymized data is available to be shared with bonafide researchers HDRUK according to their protocols"}, {"db": "ZOE covid study", "key": "https://covid.joinzoe.com", "description": "Data updates for covid study"}], "notes": [], "created": "2021-05-06T05:56:52.220Z", "modified": "2023-06-19T15:28:02.337Z"}, {"entity": "publication", "iuid": "070bbe0d37c84be0a2e31eeff5e35c3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/070bbe0d37c84be0a2e31eeff5e35c3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/070bbe0d37c84be0a2e31eeff5e35c3d"}}, "title": "Therapeutic plasma exchange (TPE) as a plausible rescue therapy in severe vaccine-induced immune thrombotic thrombocytopenia", "authors": [{"family": "Rock", "given": "Gail", "initials": "G"}, {"family": "Weber", "given": "Viktoria", "initials": "V"}, {"family": "Stegmayr", "given": "Bernd", "initials": "B"}], "type": "journal-article", "published": "2021-05-00", "journal": {"title": "Transfusion and Apheresis Science", "issn": "1473-0502", "issn-l": null, "volume": null, "issue": null, "pages": "103174"}, "abstract": null, "doi": "10.1016/j.transci.2021.103174", "pmid": null, "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-06-08T08:43:34.819Z", "modified": "2021-06-08T08:43:48.285Z"}, {"entity": "publication", "iuid": "44a461149ac34464b639e5263b01da57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44a461149ac34464b639e5263b01da57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44a461149ac34464b639e5263b01da57"}}, "title": "Stigma, Trust, and procedural integrity: Covid-19 testing in Malawi.", "authors": [{"family": "Ferree", "given": "Karen E", "initials": "KE"}, {"family": "Harris", "given": "Adam S", "initials": "AS"}, {"family": "Dulani", "given": "Boniface", "initials": "B"}, {"family": "Kao", "given": "Kristen", "initials": "K"}, {"family": "Lust", "given": "Ellen", "initials": "E"}, {"family": "Metheney", "given": "Erica", "initials": "E"}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "World Dev", "issn": "0305-750X", "volume": "141", "issue": null, "pages": "105351", "issn-l": null}, "abstract": "An emerging consensus in public health views testing for Covid-19 as key to managing the pandemic. It is often assumed that citizens have a strong desire to know their Covid-19 status, and will therefore take advantage of testing opportunities. This may not be the case in all contexts, however, especially those where citizens perceive stigma associated with the Covid-19, have low trust in health institutions, and doubt the procedural integrity of the testing process. This article explores willingness to receive a free Covid-19 test via a vignette experiment (conjoint design) embedded in a phone survey conducted in Malawi in May 2020. The experiment varied test provider (public clinic versus international health organization), proximity to illness, and reassurance of confidentiality. We find that Malawians expect higher uptake of testing in their community when the international health organization offered the test rather than a public clinic, an effect we attribute to higher trust in the organization and/or perceptions of greater capacity to ensure procedural integrity. The confidentiality reassurance did not substantially alter beliefs about the privacy of results, but did increase doubts about the willingness of community members to get tested in a public health clinic. Our findings suggest the importance of considering the demand side of testing in addition to well-known challenges of supply.", "doi": "10.1016/j.worlddev.2020.105351", "pmid": "33456104", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0305-750X(20)30479-4"}, {"db": "pmc", "key": "PMC7803152"}], "notes": [], "created": "2021-03-06T10:23:01.391Z", "modified": "2021-03-06T10:23:01.404Z"}, {"entity": "publication", "iuid": "275782e9e32446cea2ff723ecad7d2e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/275782e9e32446cea2ff723ecad7d2e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/275782e9e32446cea2ff723ecad7d2e2"}}, "title": "Role of the SphK-S1P-S1PRs pathway in invasion of the nervous system by SARS-CoV-2 infection.", "authors": [{"family": "Pan", "given": "Yuehai", "initials": "Y"}, {"family": "Gao", "given": "Fei", "initials": "F"}, {"family": "Zhao", "given": "Shuai", "initials": "S"}, {"family": "Han", "given": "Jinming", "initials": "J"}, {"family": "Chen", "given": "Fan", "initials": "F"}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Clin Exp Pharmacol Physiol", "issn": "0305-1870", "volume": "48", "issue": "5", "pages": "637-650", "issn-l": null}, "abstract": "Global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still ongoing. Before an effective vaccine is available, the development of potential treatments for resultant coronavirus disease 2019 (COVID-19) is crucial. One of the disease hallmarks is hyper-inflammatory responses, which usually leads to a severe lung disease. Patients with COVID-19 also frequently suffer from neurological symptoms such as acute diffuse encephalomyelitis, brain injury and psychiatric complications. The metabolic pathway of sphingosine-1-phosphate (S1P) is a dynamic regulator of various cell types and disease processes, including the nervous system. It has been demonstrated that S1P and its metabolic enzymes, regulating neuroinflammation and neurogenesis, exhibit important functions during viral infection. S1P receptor 1 (S1PR1) analogues including AAL-R and RP-002 inhibit pathophysiological responses at the early stage of H1N1 virus infection and then play a protective role. Fingolimod (FTY720) is an S1P receptor modulator and is being tested for treating COVID-19. Our review provides an overview of SARS-CoV-2 infection and critical role of the SphK-S1P-SIPR pathway in invasion of SARS-CoV-2 infection, particularly in the central nervous system (CNS). This may help design therapeutic strategies based on the S1P-mediated signal transduction, and the adjuvant therapeutic effects of S1P analogues to limit or prevent the interaction between the host and SARS-CoV-2, block the spread of the SARS-CoV-2, and consequently treat related complications in the CNS.", "doi": "10.1111/1440-1681.13483", "pmid": "33565127", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8014301"}], "notes": [], "created": "2021-02-10T18:59:44.359Z", "modified": "2021-07-14T07:52:09.600Z"}, {"entity": "publication", "iuid": "a5b6512797d7493d89230b70f9d0b4a3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a5b6512797d7493d89230b70f9d0b4a3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a5b6512797d7493d89230b70f9d0b4a3"}}, "title": "Residual antimicrobial agents in food originating from animals.", "authors": [{"family": "Hassan", "given": "Mohammad Mahmudul", "initials": "MM"}, {"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}, {"family": "Khan Nayem", "given": "Md Raihan", "initials": "MR"}, {"family": "Tanzin", "given": "Abu Zubayer", "initials": "AZ"}, {"family": "Badsha", "given": "Md Rahim", "initials": "MR"}, {"family": "Khan", "given": "Shahneaz Ali", "initials": "SA"}, {"family": "Ashour", "given": "Hossam M", "initials": "HM"}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Trends Food Sci Technol", "issn": "0924-2244", "volume": "111", "issue": null, "pages": "141-150", "issn-l": null}, "abstract": "The agricultural food products industry in Bangladesh depends on utilizing antimicrobials indiscriminately as growth promoters and for controlling infectious diseases. Thus, there is always a risk of antimicrobial agent accumulation in food sources that originate from agricultural production.\n\nIn the present study, we collected data from published articles between January, 2013 and December, 2019 on antimicrobial residues in human food sources such as meat, milk, eggs, and fishes.\n\nLiver contained the highest percentage of antimicrobial residues (74%; 95% CI: 59.66-85.37) against the invitro enteric pathogen Escherichia coli in layer chickens. Similar results were demonstrated in liver (68%; 95% CI: 53.30-80.48) and kidney (66%, 95% CI: 51.23-78.79) of layer chickens against Bacillus cereus and Bacillus subtilis. Amongst all antibiotics, the highest concentrations of ciprofloxacin were detected in kidney (48.57%; 95% CI: 31.38-66.01), followed by liver (47.56; 95% CI: 40.88-54.30) of broiler chickens. Ciprofloxacin was also present in liver (46.15%; 95% CI: 33.70-58.96) of layer chickens. The percentage of ciprofloxacin in thigh and breast meat in broiler bird were 41.54% (95% CI: 34.54-48.79) and 37.95% (95% CI: 31.11-45.15) respectively. Enrofloxacin was the second most dominant antimicrobial agent and was present in the liver of both types of poultry (Broiler and Layer chickens: 41.54%; 95% CI: 29.44-54.4 and 437.33%; 95% CI: 30.99-44.01). The prevalence rates of enrofloxacin in thigh and breast meat of broiler chickens were 24.10% (95% CI: 18.28-30.73) and 20.51% (95% CI: 15.08-26.87), respectively. Tetracycline, a commonly used antibiotic in livestock, was present in the liver (49.23%; 95% CI: 36.60-61.93) of layer chickens. In case of aquaculture food products, the highest amount of amoxicillin (683.2 mg/kg) was detected in Tilapia fish (Oreochromis niloticus), followed by 584.4 mg/kg in climbing perch (Anabas testudineus) and 555.6 mg/kg in Rui fish (Labeo rohita). Among the five types of fishes, Rui fish (0.000515 mg/kg) contained the highest concentrations of chloramphenicol antibiotic residues.\n\nThe presence of antimicrobial residues in meat, milk, egg, and fish is a serious public health threat due to the potential induction of antimicrobial resistance. It can negatively impact the food supply chain, especially with the current strain that it is already facing with the current COVID-19 pandemic. The findings of the present study highlight the ongoing risk of residual antimicrobial agents in food of animal origin in Bangladesh and countries with similar practices. This can draw the attention of public health officials to propose plans to mitigate or stop this practice.", "doi": "10.1016/j.tifs.2021.01.075", "pmid": "33746363", "labels": {"Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0924-2244(21)00083-2"}, {"db": "pmc", "key": "PMC7953985"}], "notes": [], "created": "2021-03-29T14:16:29.522Z", "modified": "2021-03-29T14:16:29.545Z"}, {"entity": "publication", "iuid": "a669fe2e8b544fad8541143ddb165f62", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a669fe2e8b544fad8541143ddb165f62.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a669fe2e8b544fad8541143ddb165f62"}}, "title": "Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of COVID-19 death.", "authors": [{"family": "Szekely", "given": "Laszlo", "initials": "L", "orcid": "0000-0001-6144-6573", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/906008558d5c4734bb28388154759186.json"}}, {"family": "Bozoky", "given": "Bela", "initials": "B"}, {"family": "Bendek", "given": "Matyas", "initials": "M"}, {"family": "Ostad", "given": "Masih", "initials": "M"}, {"family": "Lavignasse", "given": "Pablo", "initials": "P"}, {"family": "Haag", "given": "Lars", "initials": "L", "orcid": "0000-0002-9268-0562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fd8deb7580e4371901510e07ca478ab.json"}}, {"family": "Wu", "given": "Jieyu", "initials": "J", "orcid": "0000-0002-7063-6990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3c151e3e7ed4d3f81fbfc398e7828ce.json"}}, {"family": "Jing", "given": "Xu", "initials": "X"}, {"family": "Gupta", "given": "Soham", "initials": "S"}, {"family": "Saccon", "given": "Elisa", "initials": "E", "orcid": "0000-0003-3283-4432", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28cbb3510cbc4bf5b4db2bee1689467f.json"}}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Cao", "given": "Yihai", "initials": "Y"}, {"family": "Bj\u00f6rnstedt", "given": "Mikael", "initials": "M"}, {"family": "Szakos", "given": "Attila", "initials": "A"}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "issn-l": null, "volume": "7", "issue": "5", "pages": "e07134"}, "abstract": "Most COVID-19 victims are old and die from unrelated causes. Here we present twelve complete autopsies, including two rapid autopsies of young patients where the cause of death was COVID-19 ARDS. The main virus induced pathology was in the lung parenchyma and not in the airways. Most coagulation events occurred in the intra-alveolar and not in the intra-vascular space and the few thrombi were mainly composed of aggregated thrombocytes. The dominant inflammatory response was the massive accumulation of CD163 + macrophages and the disappearance of T killer, NK and B-cells. The virus was replicating in the pneumocytes and macrophages but not in bronchial epithelium, endothelium, pericytes or stromal cells. The lung consolidations were produced by a massive regenerative response, stromal and epithelial proliferation and neovascularization. We suggest that thrombocyte aggregation inhibition, angiogenesis inhibition and general proliferation inhibition may have a roll in the treatment of advanced COVID-19 ARDS.", "doi": "10.1016/j.heliyon.2021.e07134", "pmid": "34056141", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC8141733"}, {"db": "pii", "key": "S2405-8440(21)01237-8"}], "notes": [], "created": "2021-06-02T13:16:12.980Z", "modified": "2023-06-19T14:35:28.386Z"}, {"entity": "publication", "iuid": "86d82d91b8c742a4b1f99b3b3e91e1e3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86d82d91b8c742a4b1f99b3b3e91e1e3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86d82d91b8c742a4b1f99b3b3e91e1e3"}}, "title": "Nitric oxide and COVID\u201019: Dose, timing and how to administer it might be crucial", "authors": [{"family": "Frostell", "given": "Claes G", "initials": "CG", "orcid": "0000-0002-7199-1310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874beab519f143db8659a7936aa46142.json"}}, {"family": "Hedenstierna", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0002-2923-6012", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cee3c79aa318422ba4bcfceeb5f5e44c.json"}}], "type": "journal-article", "published": "2021-05-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "0001-5172", "volume": "65", "issue": "5", "pages": "576-577", "issn-l": null}, "abstract": "Nitric oxide (NO) for inhalation has been a clinical option in the ICU since the early 1990s. Much has been written and claimed after the initial enthusiasm over an acutely improved arterial oxygenation in adult patients with ARDS. A few years ago, a meta-analysis (1) concluded that the regular use of inhaled NO (iNO) in patients with ARDS outside a clinical trial could not be recommended, as no benefit such as reduced mortality or time on the ventilator could be identified in published randomized studies.", "doi": "10.1111/aas.13788", "pmid": "33533477", "labels": {"Type: Other": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-04T18:11:58.380Z", "modified": "2021-06-18T11:22:27.514Z"}, {"entity": "publication", "iuid": "50767935110245d6b5ce53ca33f247c3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50767935110245d6b5ce53ca33f247c3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50767935110245d6b5ce53ca33f247c3"}}, "title": "Mortality trends among hospitalised COVID-19 patients in Sweden: A nationwide observational cohort study", "authors": [{"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-8801-3169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37509c3832244b019b91a1fe2cbe183e.json"}}, {"family": "Wahlstr\u00f6m", "given": "Erik", "initials": "E", "orcid": "0000-0002-0800-8520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f623177f84a4f4ba85571b106e4cec5.json"}}, {"family": "Walther", "given": "Sten", "initials": "S"}, {"family": "Bennet-Bark", "given": "Anna M", "initials": "AM"}, {"family": "Heurgren", "given": "Mona", "initials": "M"}, {"family": "Lind\u00e9n", "given": "Thomas", "initials": "T"}, {"family": "Holm", "given": "Johanna", "initials": "J", "orcid": "0000-0002-0220-3288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33faae9af4924abdb8f29a6abf0d2f2a.json"}}, {"family": "Hanberger", "given": "H\u00e5kan", "initials": "H", "orcid": "0000-0002-4199-0229", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ccccceb630874fc5ab7507a313b59039.json"}}], "type": "journal-article", "published": "2021-05-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "4", "issue": null, "pages": "100054", "issn-l": null}, "abstract": "It is important to know if mortality among hospitalised COVID-19 patients has changed as the pandemic has progressed. The aim of this study was to describe the dynamics over time of mortality among patients hospitalised for COVID-19 in Sweden, using nationwide data compiled by the Swedish National Board of Health and Welfare.\n\nObservational cohort study where all patients hospitalised in Sweden between March 1 and September 30, 2020, with SARS-CoV-2 RNA positivity 14 days before to 5 days after admission and a discharge code for COVID-19 were included. Outcome was 60-day all-cause mortality. Patients were categorised according to month of hospital admission. Poisson regression was used to estimate the relative risk of death by month of admission, adjusting for, age, sex, comorbidities, care dependency, country of birth, healthcare region, and Simplified Acute Physiology, version 3 (patients in intensive care units; ICU).\n\nA total of 17,140 patients were included, of which 2943 died within 60 days of admission. The overall 60-day mortality was thus 17\u00b72% (95% CI, 16\u00b76%-17\u00b77%), and it decreased from 24\u00b77% (95% CI, 23\u00b70%-26\u00b75%) in March to 10\u00b74% (95% CI, 8\u00b79%-12\u00b71%) post-wave (July-September). Adjusted relative risk (RR) of death was 0\u00b746 (95% CI, 0\u00b739-0\u00b754) post-wave, using March as reference. Corresponding RR for patients not admitted to ICU and those admitted to ICU were 0\u00b749 (95% CI, 0\u00b742-0\u00b759) and 0\u00b749 (95% CI, 0\u00b733-0\u00b772), respectively. The proportion of patients admitted to ICU decreased from 19\u00b74% (95% CI, 17\u00b79%-21\u00b71%) in the March cohort to 8\u00b79% (95% CI, 7\u00b75%-10\u00b76%) post-wave.\n\nThere was a gradual decline in mortality during the spring of 2020 in Swedish hospitalised COVID-19 patients, independent of baseline patient characteristics. Future research is needed to explain the reasons for this decline. The changing COVID-19 mortality should be taken into account when management and results of studies from the first pandemic wave are evaluated.\n\nThis study was funded by Sweden's National Board of Health and Welfare.", "doi": "10.1016/j.lanepe.2021.100054", "pmid": "33997829", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00031-4"}, {"db": "pmc", "key": "PMC7907732"}], "notes": [], "created": "2021-05-21T17:00:23.534Z", "modified": "2022-11-21T15:34:05.650Z"}, {"entity": "publication", "iuid": "9b66926507624c89bdbb6a379fc5f0d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b66926507624c89bdbb6a379fc5f0d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b66926507624c89bdbb6a379fc5f0d5"}}, "title": "Lockdown Measures Which Reduced Greenhouse Gas Emissions With Little Negative Impact on Quality of Life.", "authors": [{"family": "Niemi", "given": "Maria", "initials": "M", "orcid": "0000-0001-5407-6981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/335195cc925f4f438775330e3a1f5a8e.json"}}, {"family": "Skelton", "given": "Alasdair", "initials": "A", "orcid": "0000-0002-3732-7993", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1be6eb7f00b14da890385f496318bf7a.json"}}, {"family": "Noone", "given": "Kevin", "initials": "K", "orcid": "0000-0001-7095-7412", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e045eacf18242a2a27a31f1b56738dd.json"}}, {"family": "Olsson", "given": "Mats J", "initials": "MJ", "orcid": "0000-0001-5592-3759", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cdd692617b7d475dba4532b2d28a8cc6.json"}}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Earths Future", "issn": "2328-4277", "volume": "9", "issue": "5", "pages": "e2020EF001909", "issn-l": null}, "abstract": "Lockdown measures in response to the new Covid-19 virus have caused the largest ever fall of annual greenhouse gas emissions. A key question that we attempt to answer in this study is which, if any, of these measures can be productively encouraged post-lockdown in efforts to sustain at least part of this reduction in emissions. Sweden is uniquely suited for our study because the voluntary nature of lockdown in Sweden allowed us to assess the level of compliance to recommendations and its effects on greenhouse gas emissions. First, we assessed the change of perceived quality of life (QOL) among 746 individuals from Stockholm region due to adhering to lockdown measures. Second, we calculated the associated change of annual per capita greenhouse emissions. We found that avoiding travel for work, avoiding purchasing, and avoiding restaurants had the least negative effect on QOL, and at the same time the largest positive effect on carbon dioxide equivalent (CO2e) emission reductions. We conclude that these are potential leverage points for stimulating behavioral change that has a positive climatic impact.", "doi": "10.1029/2020EF001909", "pmid": "34230885", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "EFT2794"}, {"db": "pmc", "key": "PMC8250258"}], "notes": [], "created": "2021-08-06T08:34:07.410Z", "modified": "2021-08-06T08:34:07.531Z"}, {"entity": "publication", "iuid": "1bd81d0ffef846729bedaa9804f6fdd1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1bd81d0ffef846729bedaa9804f6fdd1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1bd81d0ffef846729bedaa9804f6fdd1"}}, "title": "Higher vs Lower Doses of Dexamethasone in Patients with COVID\u201019 and Severe Hypoxia (COVID STEROID 2) trial: Protocol for a secondary Bayesian analysis", "authors": [{"family": "Granholm", "given": "Anders", "initials": "A", "orcid": "0000-0001-5799-7655", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d058ecb91d4c482abbee511b044ddf75.json"}}, {"family": "Munch", "given": "Marie Warrer", "initials": "MW", "orcid": "0000-0003-1127-9599", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd56f64f991042da935f6f3836e087b0.json"}}, {"family": "Myatra", "given": "Sheila Nainan", "initials": "SN"}, {"family": "Vijayaraghavan", "given": "Bharath Kumar Tirupakuzhi", "initials": "BKT"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Wahlin", "given": "Rebecka Rubenson", "initials": "RR"}, {"family": "Jakob", "given": "Stephan M", "initials": "SM"}, {"family": "Cioccari", "given": "Luca", "initials": "L"}, {"family": "Kj\u00e6r", "given": "Maj\u2010Brit N\u00f8rregaard", "initials": "MN", "orcid": "0000-0002-6536-0504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df8fa07399b448a5b689089e505dab58.json"}}, {"family": "Vesterlund", "given": "Gitte Kingo", "initials": "GK", "orcid": "0000-0001-5221-3938", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6eb5ff4bc5054887bfac267b8c8af411.json"}}, {"family": "Meyhoff", "given": "Tine Sylvest", "initials": "TS", "orcid": "0000-0002-1840-1596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/766fe5fd044944faabf6a96e8d6a72f0.json"}}, {"family": "Helleberg", "given": "Marie", "initials": "M"}, {"family": "M\u00f8ller", "given": "Morten Hylander", "initials": "MH", "orcid": "0000-0002-6378-9673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1cf88aaa5c9436a8e70ddfe39cfe4e8.json"}}, {"family": "Benfield", "given": "Thomas", "initials": "T"}, {"family": "Venkatesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Hammond", "given": "Naomi", "initials": "N"}, {"family": "Micallef", "given": "Sharon", "initials": "S"}, {"family": "Bassi", "given": "Abhinav", "initials": "A"}, {"family": "John", "given": "Oommen", "initials": "O"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Kristiansen", "given": "Klaus Tjelle", "initials": "KT"}, {"family": "Ulrik", "given": "Charlotte Suppli", "initials": "CS"}, {"family": "J\u00f8rgensen", "given": "Vibeke Lind", "initials": "VL"}, {"family": "Smitt", "given": "Margit", "initials": "M"}, {"family": "Bestle", "given": "Morten H", "initials": "MH"}, {"family": "Andreasen", "given": "Anne Sofie", "initials": "AS"}, {"family": "Poulsen", "given": "Lone Musaeus", "initials": "LM"}, {"family": "Rasmussen", "given": "Bodil Steen", "initials": "BS", "orcid": "0000-0003-2190-145X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa66146077394afea60f71d4be6daf06.json"}}, {"family": "Br\u00f8chner", "given": "Anne Craveiro", "initials": "AC"}, {"family": "Str\u00f8m", "given": "Thomas", "initials": "T"}, {"family": "M\u00f8ller", "given": "Anders", "initials": "A"}, {"family": "Khan", "given": "Mohd Saif", "initials": "MS"}, {"family": "Padmanaban", "given": "Ajay", "initials": "A"}, {"family": "Divatia", "given": "Jigeeshu Vasishtha", "initials": "JV"}, {"family": "Saseedharan", "given": "Sanjith", "initials": "S"}, {"family": "Borawake", "given": "Kapil", "initials": "K"}, {"family": "Kapadia", "given": "Farhad", "initials": "F"}, {"family": "Dixit", "given": "Subhal", "initials": "S"}, {"family": "Chawla", "given": "Rajesh", "initials": "R"}, {"family": "Shukla", "given": "Urvi", "initials": "U"}, {"family": "Amin", "given": "Pravin", "initials": "P"}, {"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Lange", "given": "Theis", "initials": "T"}, {"family": "Perner", "given": "Anders", "initials": "A", "orcid": "0000-0002-4668-0123", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5d5120bc69c433f9df2b929d6be905a.json"}}], "type": "journal-article", "published": "2021-05-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "0001-5172", "volume": "65", "issue": "5", "pages": "702-710", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) can lead to severe hypoxic respiratory failure and death. Corticosteroids decrease mortality in severely or critically ill patients with COVID-19. However, the optimal dose remains unresolved. The ongoing randomised COVID STEROID 2 trial investigates the effects of higher vs. lower doses of dexamethasone (12 vs. 6 mg intravenously daily for up to 10 days) in 1,000 adult patients with COVID-19 and severe hypoxia.\n\nThis protocol outlines the rationale and statistical methods for a secondary, pre-planned Bayesian analysis of the primary outcome (days alive without life support at day 28) and all secondary outcomes registered up to day 90. We will use hurdle-negative binomial models to estimate the mean number of days alive without life support in each group and present results as mean differences and incidence rate ratios with 95% credibility intervals (CrIs). Additional count outcomes will be analysed similarly and binary outcomes will be analysed using logistic regression models with results presented as probabilities, relative risks and risk differences with 95% CrIs. We will present probabilities of any benefit/harm, clinically important benefit/harm and probabilities of effects smaller than pre-defined clinically minimally important differences for all outcomes analysed. Analyses will be adjusted for stratification variables and conducted using weakly informative priors supplemented by sensitivity analyses using sceptic priors.\n\nThis secondary, pre-planned Bayesian analysis will supplement the primary, conventional analysis and may help clinicians, researchers and policymakers interpret the results of the COVID STEROID 2 trial while avoiding arbitrarily dichotomised interpretations of the results.", "doi": "10.1111/aas.13793", "pmid": "33583027", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-15T07:51:08.706Z", "modified": "2021-06-18T12:05:18.966Z"}, {"entity": "publication", "iuid": "306ed55d95ef4f86be1ea42f3ed30577", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/306ed55d95ef4f86be1ea42f3ed30577.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/306ed55d95ef4f86be1ea42f3ed30577"}}, "title": "Disparities in European healthcare system approaches to maintaining continuity of medication for non-communicable diseases during the COVID-19 outbreak.", "authors": [{"family": "Kardas", "given": "Przemyslaw", "initials": "P"}, {"family": "van Boven", "given": "Job Frank Martien", "initials": "JFM"}, {"family": "Pinnock", "given": "Hilary", "initials": "H"}, {"family": "Menditto", "given": "Enrica", "initials": "E"}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Tsiligianni", "given": "Ioanna", "initials": "I"}, {"family": "\u00c1gh", "given": "Tam\u00e1s", "initials": "T"}, {"family": "ENABLE collaborators", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "4", "issue": null, "pages": "100099", "issn-l": null}, "abstract": null, "doi": "10.1016/j.lanepe.2021.100099", "pmid": "33875981", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00076-4"}, {"db": "pmc", "key": "PMC8046426"}], "notes": [], "created": "2021-04-23T04:43:57.860Z", "modified": "2021-04-23T04:43:57.883Z"}, {"entity": "publication", "iuid": "35781c4aec33447ba7f2cfc838ecbc55", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/35781c4aec33447ba7f2cfc838ecbc55.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/35781c4aec33447ba7f2cfc838ecbc55"}}, "title": "Blood group type A secretors are associated with a higher risk of COVID-19 cardiovascular disease complications.", "authors": [{"family": "Mankelow", "given": "Tosti J", "initials": "TJ", "orcid": "0000-0003-3434-1973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d109f82e8870460a82565faa2f7c47dd.json"}}, {"family": "Singleton", "given": "Belinda K", "initials": "BK"}, {"family": "Moura", "given": "Pedro L", "initials": "PL", "orcid": "0000-0002-0493-5394", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf2544f4b3984c909d18106f49b9c9df.json"}}, {"family": "Stevens-Hernandez", "given": "Christian J", "initials": "CJ"}, {"family": "Cogan", "given": "Nicola M", "initials": "NM"}, {"family": "Gyorffy", "given": "Gyongyver", "initials": "G"}, {"family": "Kupzig", "given": "Sabine", "initials": "S"}, {"family": "Nichols", "given": "Luned", "initials": "L"}, {"family": "Asby", "given": "Claire", "initials": "C"}, {"family": "Pooley", "given": "Jennifer", "initials": "J"}, {"family": "Ruffino", "given": "Gabriella", "initials": "G"}, {"family": "Hosseini", "given": "Faroakh", "initials": "F"}, {"family": "Moghaddas", "given": "Fiona", "initials": "F"}, {"family": "Attwood", "given": "Marie", "initials": "M"}, {"family": "Noel", "given": "Alan", "initials": "A"}, {"family": "Cooper", "given": "Alex", "initials": "A"}, {"family": "Arnold", "given": "David T", "initials": "DT", "orcid": "0000-0003-3158-7740", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42abc73999ea4e25bed71b6538e00728.json"}}, {"family": "Hamilton", "given": "Fergus", "initials": "F", "orcid": "0000-0002-9760-4059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e862d4d0440241ecb9f9c985d638eb3d.json"}}, {"family": "Hyams", "given": "Catherine", "initials": "C", "orcid": "0000-0003-3923-1773", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e534f6c4f8c24e35b4e2df47282adfec.json"}}, {"family": "Finn", "given": "Adam", "initials": "A", "orcid": "0000-0003-1756-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd0dbeb41b344aee99a7ace518c0938c.json"}}, {"family": "Toye", "given": "Ashley M", "initials": "AM", "orcid": "0000-0003-4395-9396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/308984a5ffb44136892e9bc9d163e85d.json"}}, {"family": "Anstee", "given": "David J", "initials": "DJ", "orcid": "0000-0002-9066-1202", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2de3c70547b8454eb221ce5324686e0b.json"}}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "EJHaem", "issn": "2688-6146", "issn-l": null, "volume": "2", "issue": "2", "pages": "175-187"}, "abstract": "The SARS-CoV-2 virus causes COVID-19, an infection capable of causing severe disease and death but which can also be asymptomatic or oligosymptomatic. We investigated whether ABO blood group or secretor status was associated with COVID-19 severity. We investigated secretor status because expression of ABO glycans on secreted proteins and non-erythroid cells are controlled by a fucosyltransferase (FUT2), and inactivating FUT2 mutations result in a non-secretor phenotype which protects against some viral infections. Data combined from healthcare records and our own laboratory tests (n = 275) of hospitalized SARS-CoV-2 polymerase chain reaction positive patients confirmed higher than expected numbers of blood group A individuals compared to O (RR = 1.24, CI 95% [1.05, 1.47], p = 0.0111). There was also a significant association between group A and COVID-19-related cardiovascular complications (RR = 2.56, CI 95% [1.43, 4.55], p = 0.0011) which is independent of gender. Molecular analysis revealed that group A non-secretors are significantly less likely to be hospitalized than secretors. Testing of convalescent plasma donors, among whom the majority displayed COVID-19 symptoms and only a small minority required hospitalization, group A non-secretors were slightly over-represented. Our findings showed that group A non-secretors are not resistant to infection by SARS-CoV-2, but are more likely to experience a less severe form of associated disease.", "doi": "10.1002/jha2.180", "pmid": "34124710", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8176350"}, {"db": "pii", "key": "JHA2180"}], "notes": [], "created": "2021-06-17T07:42:38.844Z", "modified": "2023-06-19T07:44:36.576Z"}, {"entity": "publication", "iuid": "36cc2c82b9074d7480f9e6877b58a2e4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/36cc2c82b9074d7480f9e6877b58a2e4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/36cc2c82b9074d7480f9e6877b58a2e4"}}, "title": "A Method for Computerized Olfactory Assessment and Training Outside of Laboratory or Clinical Settings", "authors": [{"family": "Niedenthal", "given": "Simon", "initials": "S", "orcid": "0000-0003-4132-2287", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/afbb30dd20d446568597c1699a99e339.json"}}, {"family": "Nilsson", "given": "Johannes", "initials": "J"}, {"family": "Jerns\u00e4ther", "given": "Teodor", "initials": "T"}, {"family": "Cuartielles", "given": "David", "initials": "D"}, {"family": "Larsson", "given": "Maria", "initials": "M"}, {"family": "Olofsson", "given": "Jonas K", "initials": "JK", "orcid": "0000-0002-0856-0569", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5283494522f43cf8297e0226d08a665.json"}}], "type": "journal-article", "published": "2021-05-00", "journal": {"title": "i-Perception", "issn": "2041-6695", "volume": "12", "issue": "3", "pages": "204166952110239", "issn-l": null}, "abstract": null, "doi": "10.1177/20416695211023953", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:06:50.138Z", "modified": "2021-06-28T18:06:50.215Z"}, {"entity": "publication", "iuid": "a483737ffad34cd3a1ffd91e91ce8902", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a483737ffad34cd3a1ffd91e91ce8902.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a483737ffad34cd3a1ffd91e91ce8902"}}, "title": "The forgotten sub-regional COVID-19 response layer. The case of the WHO Eastern Mediterranean Region.", "authors": [{"family": "Ali Maher", "given": "Osama", "initials": "O"}, {"family": "Elamein Boshara", "given": "Mohamed Abdalla", "initials": "MA"}, {"family": "Pichierri", "given": "Giuseppe", "initials": "G"}, {"family": "Cegolon", "given": "Luca", "initials": "L"}, {"family": "Panu Napodano", "given": "Catello Mario", "initials": "CM"}, {"family": "Murgia", "given": "Paola", "initials": "P"}, {"family": "Bellizzi", "given": "Saverio", "initials": "S"}], "type": "journal article", "published": "2021-04-30", "journal": {"title": "J Infect Dev Ctries", "issn": "1972-2680", "volume": "15", "issue": "4", "pages": "478-479", "issn-l": null}, "abstract": "The response to the COVID-19 pandemic have been driven by epidemiology, health system characteristics and control measures in form of social/physical distancing. Guidance, information and best practices have been characterized by territorial thinking with concentration on national health system and social contexts. Information was to a large extent provided from global entities such as the World Health Organization (WHO), Centers for Disease Control and Prevention (CDC) and others. This bipolar response mechanism came to the detriment of regional and sub-regional levels. The development of the global pandemic was evaluated in terms of the performance of single countries without trying to reflect on possible regional or sub-regional results of similar characteristics in health system and social contexts. To have a clearer view of the issue of sub-regional similarities, we examined the WHO, Eastern Mediterranean Region. When examining the development of confirmed cases for countries in the region, we identified four different sub-groups similar in the development of the pandemic and the social distancing measure implemented. Despite the complicated situation, these groups gave space for thinking outside the box of traditional outbreaks or pandemic response. We think that this sub-regional approach could be very effective in addressing more characteristics and not geographically based analysis. Furthermore, this can be an area of additional conceptual approaches, modelling and concrete platforms for information and lessons learned exchange.", "doi": "10.3855/jidc.14057", "pmid": "33956646", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-17T19:05:28.720Z", "modified": "2021-05-17T19:05:28.744Z"}, {"entity": "publication", "iuid": "f8e8baec2aa84a5997263cd6b8c5edf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f8e8baec2aa84a5997263cd6b8c5edf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f8e8baec2aa84a5997263cd6b8c5edf3"}}, "title": "Fear of COVID-19 and workplace phobia among Pakistani doctors: A survey study.", "authors": [{"family": "Malik", "given": "Sadia", "initials": "S"}, {"family": "Ullah", "given": "Irfan", "initials": "I"}, {"family": "Irfan", "given": "Muhammad", "initials": "M"}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Rehman", "given": "Ibad Ur", "initials": "IU"}, {"family": "Minhas", "given": "Rafia", "initials": "R"}], "type": "journal article", "published": "2021-04-30", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "833"}, "abstract": "The novel coronavirus disease-2019 (COVID-19) has seriously affected the lives of millions of people across the world. It has also heavily burdened healthcare professionals and the virus poses serious risks for their personal and professional lives. Therefore, the present study examined the associations between fear of COVID-19 and workplace phobia among doctors in Pakistan during the COVID-19 pandemic.\r\n\r\nAn online survey was conducted among 421 doctors in Pakistan between April 10 and May 25, 2020. The Workplace Phobia Scale (WPS) and the Fear of COVID-19 Scale (FCV-19S) were the main psychometric instruments used in this study.\r\n\r\nThere was a significant positive relationship between fear of COVID-19 and workplace panic anxiety and workplace avoidance behavior. Significantly higher fear of COVID-19 was found among (i) females compared to males, (ii) doctors with 5 years or less of work experience compared to those with more than 5 years, and (iii) postgraduate trainees compared with other ranks. Two groups (doctors who were above 30 years old and postgraduate trainees) were found to have higher levels of workplace phobia compared to their counterparts. Doctors with severe levels of fear of COVID-19 had significantly higher levels of workplace panic anxiety and workplace avoidance behavior.\r\n\r\nFear of COVID-19 was significantly associated with workplace phobia which may negatively affect doctors' performance. Therefore, important steps are needed to protect doctors' health by providing sufficient resources to allay their fears and anxieties which consequently help them in carrying out their frontline duties in response to the COVID-19 pandemic.", "doi": "10.1186/s12889-021-10873-y", "pmid": "33931040", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-10873-y"}], "notes": [], "created": "2021-05-04T16:03:00.628Z", "modified": "2021-07-14T08:11:34.471Z"}, {"entity": "publication", "iuid": "0145b07c31204a1dabd9c607a0b1dccb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0145b07c31204a1dabd9c607a0b1dccb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0145b07c31204a1dabd9c607a0b1dccb"}}, "title": "A SARS-CoV-2 (COVID-19) biological network to find targets for drug repurposing.", "authors": [{"family": "Habibi", "given": "Mahnaz", "initials": "M"}, {"family": "Taheri", "given": "Golnaz", "initials": "G"}, {"family": "Aghdam", "given": "Rosa", "initials": "R"}], "type": "journal article", "published": "2021-04-30", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "9378", "issn-l": "2045-2322"}, "abstract": "The Coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus needs a fast recognition of effective drugs to save lives. In the COVID-19 situation, finding targets for drug repurposing can be an effective way to present new fast treatments. We have designed a two-step solution to address this approach. In the first step, we identify essential proteins from virus targets or their associated modules in human cells as possible drug target candidates. For this purpose, we apply two different algorithms to detect some candidate sets of proteins with a minimum size that drive a significant disruption in the COVID-19 related biological networks. We evaluate the resulted candidate proteins sets with three groups of drugs namely Covid-Drug, Clinical-Drug, and All-Drug. The obtained candidate proteins sets approve 16 drugs out of 18 in the Covid-Drug, 273 drugs out of 328 in the Clinical-Drug, and a large number of drugs in the All-Drug. In the second step, we study COVID-19 associated proteins sets and recognize proteins that are essential to disease pathology. This analysis is performed using DAVID to show and compare essential proteins that are contributed between the COVID-19 comorbidities. Our results for shared proteins show significant enrichment for cardiovascular-related, hypertension, diabetes type 2, kidney-related and lung-related diseases.", "doi": "10.1038/s41598-021-88427-w", "pmid": "33931664", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-88427-w"}, {"db": "github", "key": "(https://github.com/rosaaghdam/ Drug-Target", "description": "Datasets and the codes of the algorithms are available at the github repository"}], "notes": [], "created": "2021-05-04T16:02:32.234Z", "modified": "2021-11-18T10:16:36.362Z"}, {"entity": "publication", "iuid": "6c3d627eeb444987aba0fa10a8899671", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c3d627eeb444987aba0fa10a8899671.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c3d627eeb444987aba0fa10a8899671"}}, "title": "Prostate cancer diagnosis, staging, and treatment in Sweden during the first phase of the COVID-19 pandemic.", "authors": [{"family": "Fallara", "given": "Giuseppe", "initials": "G"}, {"family": "Sandin", "given": "Fredrik", "initials": "F"}, {"family": "Styrke", "given": "Johan", "initials": "J"}, {"family": "Carlsson", "given": "Stefan", "initials": "S"}, {"family": "Lissbrant", "given": "Ingela Franck", "initials": "IF"}, {"family": "Ahlgren", "given": "Johan", "initials": "J"}, {"family": "Bratt", "given": "Ola", "initials": "O"}, {"family": "Lambe", "given": "Mats", "initials": "M"}, {"family": "Stattin", "given": "P\u00e4r", "initials": "P"}], "type": "journal article", "published": "2021-04-29", "journal": {"title": "Scand J Urol", "issn": "2168-1813", "issn-l": null, "volume": null, "issue": null, "pages": "1-8"}, "abstract": "The first case of COVID-19 in Sweden was diagnosed in late January 2020, the first recommendations against the spread of the virus were released in mid-March, and the peak of the first wave of the pandemic was reached in March-June. The aim of this cross-sectional study was to assess the short-term effects of the first wave of the COVID-19 pandemic on prostate cancer (PCa) diagnosis, staging, and treatment.\r\n\r\nData in the National Prostate Cancer Register (NPCR) of Sweden on newly diagnosed PCa cases and on the number of diagnostic and therapeutic procedures performed between 18 March 2020 and 2 June 2020 were compared with those in the corresponding time periods in 2017-2019, as reported until January 31 of the year after each study period.\r\n\r\nDuring the study period in 2020, 36% fewer PCa cases were registered in NPCR compared with the corresponding time period in previous years: 1458 cases in 2020 vs a mean of 2285 cases in 2017-2019. The decrease in new PCa registrations was more pronounced in men above age 75 years, down 51%, than in men aged 70-75, down 37%, and in men below age 70, down 28%. There was no decrease in the number of radical prostatectomies and number of radical radiotherapy courses increased by 32%.\r\n\r\nDuring the peak of the first phase of the COVID-19 pandemic, the number of men diagnosed with PCa in Sweden decreased by one third compared with previous years, whereas there was no decrease in the number of curative treatments.", "doi": "10.1080/21681805.2021.1910341", "pmid": "33913376", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-30T04:14:25.081Z", "modified": "2021-08-25T14:32:40.013Z"}, {"entity": "publication", "iuid": "a2a8bc6a039241c1a9cbd3f58591f371", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2a8bc6a039241c1a9cbd3f58591f371.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2a8bc6a039241c1a9cbd3f58591f371"}}, "title": "OxCOVID19 Database, a multimodal data repository for better understanding the global impact of COVID-19", "authors": [{"family": "Mahdi", "given": "Adam", "initials": "A"}, {"family": "B\u0142aszczyk", "given": "Piotr", "initials": "P"}, {"family": "D\u0142otko", "given": "Pawe\u0142", "initials": "P"}, {"family": "Salvi", "given": "Dario", "initials": "D"}, {"family": "Chan", "given": "Tak Shing", "initials": "TS"}, {"family": "Harvey", "given": "John", "initials": "J"}, {"family": "Gurnari", "given": "Davide", "initials": "D"}, {"family": "Wu", "given": "Yue", "initials": "Y"}, {"family": "Farhat", "given": "Ahmad", "initials": "A"}, {"family": "Hellmer", "given": "Niklas", "initials": "N"}, {"family": "Zarebski", "given": "Alexander", "initials": "A"}, {"family": "Hogan", "given": "Bernie", "initials": "B"}, {"family": "Tarassenko", "given": "Lionel", "initials": "L"}], "type": "journal-article", "published": "2021-04-29", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": null}, "abstract": null, "doi": "10.1038/s41598-021-88481-4", "pmid": "33927237", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://github.com/covid19db/data", "description": "Code for data acquisition and cleaning used in the processing of assembling the OxCOVID19 Database"}, {"db": "URL", "key": "https://doi.org/10.6084/m9.figshare.12746150", "description": "Static data (snapshot described in the manuscript) with a DOI"}, {"db": "URL", "key": "https://github.com/covid19db/data/tree/master/data-epidemiology", "description": "Latest data, epidemiology: number of confirmed cases and deaths for different countries, etc."}, {"db": "URL", "key": "https://github.com/covid19db/data/tree/master/data-government-response", "description": "Latest data, government response: data on government response to COVID-19"}, {"db": "URL", "key": "https://github.com/covid19db/data/tree/master/data-mobility", "description": "Latest data, mobility: human mobility collected by mobile phones"}], "notes": [], "created": "2021-05-04T16:11:05.623Z", "modified": "2021-06-21T14:57:10.184Z"}, {"entity": "publication", "iuid": "37a0f26523b8445a96c1a38b8538bf9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/37a0f26523b8445a96c1a38b8538bf9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/37a0f26523b8445a96c1a38b8538bf9c"}}, "title": "Irrational pharmacy practice and inadequate health care services in Bangladesh: a lesson learned from COVID-19 pandemic.", "authors": [{"family": "Jakaria", "given": "Md", "initials": "M"}, {"family": "Azam", "given": "Shofiul", "initials": "S"}, {"family": "Siddiqui", "given": "Shafayet Ahmed", "initials": "SA"}, {"family": "Hoq", "given": "Mohammad Injamul", "initials": "MI"}, {"family": "Islam", "given": "Mohammad Safiqul", "initials": "MS"}], "type": "editorial", "published": "2021-04-29", "journal": {"title": "J Basic Clin Physiol Pharmacol", "issn": "2191-0286", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1515/jbcpp-2020-0505", "pmid": "33915611", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "jbcpp-2020-0505"}], "notes": [], "created": "2021-05-04T16:29:12.566Z", "modified": "2021-05-04T16:29:28.541Z"}, {"entity": "publication", "iuid": "b3c273a0542e4e4db386a5c04855600f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b3c273a0542e4e4db386a5c04855600f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b3c273a0542e4e4db386a5c04855600f"}}, "title": "Endothelin Antagonism and Sodium Glucose Co-transporter 2 Inhibition A Potential Combination Therapeutic Strategy for COVID-19.", "authors": [{"family": "Fisk", "given": "Marie", "initials": "M"}, {"family": "Althage", "given": "Magnus", "initials": "M"}, {"family": "Moosmang", "given": "Sven", "initials": "S"}, {"family": "Greasley", "given": "Peter J", "initials": "PJ"}, {"family": "Cope", "given": "Andrew P", "initials": "AP"}, {"family": "Jayne", "given": "David Rw", "initials": "DR"}, {"family": "Galloway", "given": "James", "initials": "J"}, {"family": "Hall", "given": "Frances", "initials": "F"}, {"family": "Wilkinson", "given": "Ian B", "initials": "IB"}, {"family": "Ambery", "given": "Philip", "initials": "P"}, {"family": "Cheriyan", "given": "Joseph", "initials": "J"}], "type": "journal article", "published": "2021-04-29", "journal": {"title": "Pulm Pharmacol Ther", "issn": "1522-9629", "volume": null, "issue": null, "pages": "102035", "issn-l": null}, "abstract": "The novel coronavirus 2019 (COVID-19) infection caused by SARS-CoV-2 is a global pandemic that requires a multi-faceted approach to tackle this unprecedent health crisis. Therapeutics to treat COVID-19 are an integral part of any such management strategy and there is a substantial unmet need for treatments for individuals most at risk of severe disease. This perspective review provides rationale of a combined therapeutic regimen of selective endothelin-A (ET-A) receptor antagonism and sodium glucose co-transporter-2 (SGLT-2) inhibition to treat COVID-19. Endothelin is a potent vasoconstrictor with pro-inflammatory and atherosclerotic effects. It is upregulated in a number of conditions including acute respiratory distress syndrome and cardiovascular disease. Endothelin mediates vasocontractility via endothelin (ET-A and ET-B) receptors on vascular smooth muscle cells (VSMCs). ET-B receptors regulate endothelin clearance and are present on endothelial cells, where in contrast to their role on VSMCs, mediate vasodilation. Therefore, selective endothelin-A (ET-A) receptor inhibition is likely the optimal approach to attenuate the injurious effects of endothelin and may reduce ventilation-perfusion mismatch and pulmonary inflammation, whilst improving pulmonary haemodynamics and oxygenation. SGLT-2 inhibition may dampen inflammatory cytokines, reduce hyperglycaemia if present, improve endothelial function, cardiovascular haemodynamics and cellular bioenergetics. This combination therapeutic approach may therefore have beneficial effects to mitigate both the pulmonary, metabolic and cardiorenal manifestations of COVID-19. Given these drug classes include medicines licensed to treat heart failure, diabetes and pulmonary hypertension respectively, information regarding their safety profile is established. Randomised controlled clinical trials are the best way to determine efficacy and safety of these medicines in COVID-19.", "doi": "10.1016/j.pupt.2021.102035", "pmid": "33933611", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1094-5539(21)00047-X"}], "notes": [], "created": "2021-05-04T16:01:42.634Z", "modified": "2021-05-04T16:02:01.268Z"}, {"entity": "publication", "iuid": "61a3cad77c90462490c5d783f81558d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61a3cad77c90462490c5d783f81558d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61a3cad77c90462490c5d783f81558d9"}}, "title": "Association of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes", "authors": [{"family": "Norman", "given": "Mikael", "initials": "M"}, {"family": "Nav\u00e9r", "given": "Lars", "initials": "L"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Ahlberg", "given": "Mia", "initials": "M"}, {"family": "Hervius Askling", "given": "Helena", "initials": "H"}, {"family": "Aronsson", "given": "Bernice", "initials": "B"}, {"family": "Bystr\u00f6m", "given": "Emma", "initials": "E"}, {"family": "Jonsson", "given": "Jerker", "initials": "J"}, {"family": "Sengpiel", "given": "Verena", "initials": "V"}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}, {"family": "H\u00e5kansson", "given": "Stellan", "initials": "S"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}], "type": "journal-article", "published": "2021-04-29", "journal": {"title": "JAMA", "issn": "0098-7484", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The outcomes of newborn infants of women testing positive for SARS-CoV-2 in pregnancy is unclear.\n\nTo evaluate neonatal outcomes in relation to maternal SARS-CoV-2 test positivity in pregnancy.\n\nNationwide, prospective cohort study based on linkage of the Swedish Pregnancy Register, the Neonatal Quality Register, and the Register for Communicable Diseases. Ninety-two percent of all live births in Sweden between March 11, 2020, and January 31, 2021, were investigated for neonatal outcomes by March 8, 2021. Infants with malformations were excluded. Infants of women who tested positive for SARS-CoV-2 were matched, directly and using propensity scores, on maternal characteristics with up to 4 comparator infants.\n\nMaternal test positivity for SARS-CoV-2 in pregnancy.\n\nIn-hospital mortality; neonatal resuscitation; admission for neonatal care; respiratory, circulatory, neurologic, infectious, gastrointestinal, metabolic, and hematologic disorders and their treatments; length of hospital stay; breastfeeding; and infant test positivity for SARS-CoV-2.\n\nOf 88 159 infants (49.0% girls), 2323 (1.6%) were delivered by mothers who tested positive for SARS-CoV-2. The mean gestational age of infants of SARS-CoV-2-positive mothers was 39.2 (SD, 2.2) weeks vs 39.6 (SD, 1.8) weeks for comparator infants, and the proportions of preterm infants (gestational age <37 weeks) were 205/2323 (8.8%) among infants of SARS-CoV-2-positive mothers and 4719/85 836 (5.5%) among comparator infants. After matching on maternal characteristics, maternal SARS-CoV-2 test positivity was significantly associated with admission for neonatal care (11.7% vs 8.4%; odds ratio [OR], 1.47; 95% CI, 1.26-1.70) and with neonatal morbidities such as respiratory distress syndrome (1.2% vs 0.5%; OR, 2.40; 95% CI, 1.50-3.84), any neonatal respiratory disorder (2.8% vs 2.0%; OR, 1.42; 95% CI, 1.07-1.90), and hyperbilirubinemia (3.6% vs 2.5%; OR, 1.47; 95% CI, 1.13-1.90). Mortality (0.30% vs 0.12%; OR, 2.55; 95% CI, 0.99-6.57), breastfeeding rates at discharge (94.4% vs 95.1%; OR, 0.84; 95% CI, 0.67-1.05), and length of stay in neonatal care (median, 6 days in both groups; difference, 0 days; 95% CI, -2 to 7 days) did not differ significantly between the groups. Twenty-one infants (0.90%) of SARS-CoV-2-positive mothers tested positive for SARS-CoV-2 in the neonatal period; 12 did not have neonatal morbidity, 9 had diagnoses with unclear relation to SARS-CoV-2, and none had congenital pneumonia.\n\nIn a nationwide cohort of infants in Sweden, maternal SARS-CoV-2 infection in pregnancy was significantly associated with small increases in some neonatal morbidities. Given the small numbers of events for many of the outcomes and the large number of statistical comparisons, the findings should be interpreted as exploratory.", "doi": "10.1001/jama.2021.5775", "pmid": "33914014", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-29T16:47:53.604Z", "modified": "2021-04-30T04:16:25.471Z"}, {"entity": "publication", "iuid": "f5e42570b7434d6ab37a5f6d964a3fdf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f5e42570b7434d6ab37a5f6d964a3fdf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f5e42570b7434d6ab37a5f6d964a3fdf"}}, "title": "The association between high risk of sleep apnea, comorbidities, and risk of COVID-19: a population-based international harmonized study", "authors": [{"family": "Chung", "given": "Frances", "initials": "F"}, {"family": "Waseem", "given": "Rida", "initials": "R"}, {"family": "Pham", "given": "Chi", "initials": "C"}, {"family": "Penzel", "given": "Thomas", "initials": "T"}, {"family": "Han", "given": "Fang", "initials": "F"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Espie", "given": "Colin A", "initials": "CA"}, {"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J"}, {"family": "Saaresranta", "given": "Tarja", "initials": "T"}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK"}, {"family": "Nadorff", "given": "Michael R", "initials": "MR"}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L"}, {"family": "Plazzi", "given": "Guiseppe", "initials": "G"}, {"family": "Merikanto", "given": "Ilona", "initials": "I"}, {"family": "Matsui", "given": "Kentaro", "initials": "K"}, {"family": "Leger", "given": "Damien", "initials": "D"}, {"family": "Sieminski", "given": "Mariusz", "initials": "M"}, {"family": "Mota-Rolim", "given": "Sergio", "initials": "S"}, {"family": "Inoue", "given": "Yuichi", "initials": "Y"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "International COVID Sleep Study (ICOSS) group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-04-28", "journal": {"title": "Sleep Breath", "issn": "1522-1709", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Obstructive sleep apnea (OSA) may increase the risk of severe COVID-19; however, the level of potential modulation has not yet been established. The objective of the study was to determine the association between high risk of OSA, comorbidities, and increased risk for COVID-19, hospitalization, and intensive care unit (ICU) treatment.\r\n\r\nWe conducted a cross-sectional population-based web survey in adults in 14 countries/regions. The survey included sociodemographic variables and comorbidities. Participants were asked questions about COVID-19, hospitalization, and ICU treatment. Standardized questionnaire (STOP questionnaire for high risk of OSA) was included. Multivariable logistic regression was conducted adjusting for various factors.\r\n\r\nOut of 26,539 respondents, 20,598 (35.4% male) completed the survey. Mean age and BMI of participants were 41.5 \u00b1 16.0 years and 24.0 \u00b1 5.0 kg/m 2, respectively. The prevalence of physician-diagnosed OSA was 4.1% and high risk of OSA was 9.5%. We found that high risk of OSA (adjusted odds ratio (aOR) 1.72, 95% confidence interval (CI): 1.20, 2.47) and diabetes (aOR 2.07, 95% CI: 1.23, 3.48) were associated with reporting of a COVID-19 diagnosis. High risk for OSA (aOR 2.11, 95% CI: 1.10-4.01), being male (aOR: 2.82, 95% CI: 1.55-5.12), having diabetes (aOR: 3.93, 95% CI: 1.70-9.12), and having depression (aOR: 2.33, 95% CI: 1.15-4.77) were associated with increased risk of hospitalization or ICU treatment.\r\n\r\nParticipants at high risk of OSA had increased odds of having COVID-19 and were two times more likely to be hospitalized or treated in ICU.", "doi": "10.1007/s11325-021-02373-5", "pmid": "33907966", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11325-021-02373-5"}], "notes": [], "created": "2021-04-29T09:42:48.077Z", "modified": "2021-07-14T08:09:42.536Z"}, {"entity": "publication", "iuid": "4bfc7bf6f16c4fa9b82e7973184438e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4bfc7bf6f16c4fa9b82e7973184438e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4bfc7bf6f16c4fa9b82e7973184438e2"}}, "title": "SVEPM 2020 - Resilience and community support in the first year of the COVID-19 pandemic: The Society for Veterinary Epidemiology and Preventive Medicine Annual Conference, extraordinarily held online.", "authors": [{"family": "D\u00f3rea", "given": "Fernanda C", "initials": "FC"}, {"family": "Vergne", "given": "Timoth\u00e9e", "initials": "T"}, {"family": "Brennan", "given": "Marnie", "initials": "M"}, {"family": "van Schaik", "given": "Gerdien", "initials": "G"}, {"family": "Barrett", "given": "Damien", "initials": "D"}, {"family": "Carmo", "given": "Lu\u00eds Pedro", "initials": "LP"}, {"family": "Robinson", "given": "Philip A", "initials": "PA"}, {"family": "Brodbelt", "given": "Dave C", "initials": "DC"}, {"family": "McIntyre", "given": "K Marie", "initials": "KM"}], "type": "editorial", "published": "2021-04-28", "journal": {"title": "Prev Vet Med", "issn": "1873-1716", "volume": "191", "issue": null, "pages": "105368", "issn-l": null}, "abstract": null, "doi": "10.1016/j.prevetmed.2021.105368", "pmid": "33933917", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0167-5877(21)00112-4"}], "notes": [], "created": "2021-05-04T16:01:16.608Z", "modified": "2021-05-04T16:01:16.631Z"}, {"entity": "publication", "iuid": "26e5d7282b7a402c9c5a0c78f0b36244", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26e5d7282b7a402c9c5a0c78f0b36244.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26e5d7282b7a402c9c5a0c78f0b36244"}}, "title": "Occupational burnout and job satisfaction among physicians in times of COVID-19 crisis: a convergent parallel mixed-method study.", "authors": [{"family": "Alrawashdeh", "given": "Hamzeh Mohammad", "initials": "HM"}, {"family": "Al-Tammemi", "given": "Ala'a B", "initials": "AB"}, {"family": "Alzawahreh", "given": "Mohammad Kh", "initials": "MK"}, {"family": "Al-Tamimi", "given": "Ashraf", "initials": "A"}, {"family": "Elkholy", "given": "Mohamed", "initials": "M"}, {"family": "Al Sarireh", "given": "Fawaz", "initials": "F"}, {"family": "Abusamak", "given": "Mohammad", "initials": "M"}, {"family": "Elehamer", "given": "Nafisa M K", "initials": "NMK"}, {"family": "Malkawi", "given": "Ahmad", "initials": "A"}, {"family": "Al-Dolat", "given": "Wedad", "initials": "W"}, {"family": "Abu-Ismail", "given": "Luai", "initials": "L"}, {"family": "Al-Far", "given": "Ali", "initials": "A"}, {"family": "Ghoul", "given": "Imene", "initials": "I"}], "type": "journal article", "published": "2021-04-28", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "811"}, "abstract": "Healthcare professionals including physicians were subjected to an increased workload during the COVID-19 crisis, leaving them exposed to significant physical and psychological distress. Therefore, our present study aimed to (i) assess the prevalence of burnout and levels of job satisfaction among physicians in Jordan, and (ii) explore physicians' opinions, experiences, and perceptions during the pandemic crisis.\r\n\r\nThis was a mixed-method study that utilized a structured web-based questionnaire and semi-structured individual interviews. The 10-Item Burnout Measure-Short version (BMS), and the 5-Item Short Index of Job Satisfaction (SIJS) were adopted to assess occupational burnout and job satisfaction, respectively. Semi-structured interviews were conducted, based on a conceptual framework that was developed from Herzberg's Two-Factor Theory of Motivation and Job Demands-Resources Model. Descriptive statistics and regression models, as well as inductive thematic analysis, were used to analyze quantitative and qualitative data, respectively.\r\n\r\nA total of 973 survey responses and 11 interviews were included in our analysis. The prevalence of burnout among physicians was (57.7%). Several significant factors were positively associated with burnout, including female gender, working at highly loaded hospitals, working for long hours, doing night shifts, lack of sufficient access to personal protective equipment, and being positively tested for SARS-CoV-2. Regarding job satisfaction, regression analysis revealed that age was positively associated with higher levels of job satisfaction. On contrary, being a general practitioner or specialist, working at highly loaded hospitals, low salaries, and suffering from burnout have predicted lower levels of job satisfaction. Besides, four themes have emerged from the thematic analysis: (i) Work-induced psychological distress during the pandemic, (ii) Decision-driven satisfactory and dissatisfactory experiences, (iii) Impact of the pandemic on doctor-patient communication and professional skills, and (iv) Economic impacts of the pandemic crisis and lockdown.\r\n\r\nA significant physical and psychological burden was associated with the COVID-19 pandemic. Reliable efforts should be implemented aiming at protecting physicians' physical and mental wellbeing, enhancing their working conditions, and raising awareness about burnout. Evidence-based decisions and proper utilization of financial and human resources at institutional and national levels are believed to be crucial for the sustainability of the health workforce, especially in crises.", "doi": "10.1186/s12889-021-10897-4", "pmid": "33906619", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-10897-4"}, {"db": "URL", "key": "https://doi.org/10.6084/m9.figshare.14058185.v1", "description": "Raw dataset: individual-level demographic, occupational, COVID-19, burnout, etc. data"}], "notes": [], "created": "2021-04-29T09:51:29.677Z", "modified": "2021-07-14T08:10:43.856Z"}, {"entity": "publication", "iuid": "0d490bda6d954f7d80ad15406ed1d900", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d490bda6d954f7d80ad15406ed1d900.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d490bda6d954f7d80ad15406ed1d900"}}, "title": "Organotypic human ex vivo models for coronavirus disease 2019 research and drug development.", "authors": [{"family": "Youhanna", "given": "Sonia", "initials": "S"}, {"family": "Wright", "given": "Shane C", "initials": "SC"}, {"family": "Lauschke", "given": "Volker M", "initials": "VM"}], "type": "journal article", "published": "2021-04-27", "journal": {"title": "Curr Opin Pharmacol", "issn": "1471-4973", "volume": "59", "issue": null, "pages": "11-18", "issn-l": null}, "abstract": "Since the discovery of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019, intense research efforts on an unprecedented scale have focused on the study of viral entry mechanisms and adaptive immunity. While the identification of angiotensin-converting enzyme 2 (ACE2) and other co-receptors has elucidated the molecular and structural basis for viral entry, the pathobiological mechanisms of SARS-CoV-2 in human tissues are less understood. Recent advances in bioengineering have opened opportunities for the use of organotypic human tissue models to investigate host-virus interactions and test antiviral drug candidates in a physiological context. Although it is too early to accurately quantify the added value of these systems compared with conventional cell systems, it can be assumed that these advanced three-dimensional (3D) models contribute toward improved result translation. This mini-review summarizes recent work to study SARS-CoV-2 infection in human 3D tissue models with an emphasis on the pharmacological tools that have been developed to understand and prevent viral entry and replication.", "doi": "10.1016/j.coph.2021.04.006", "pmid": "34029832", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1471-4892(21)00050-3"}, {"db": "pmc", "key": "PMC8075816"}], "notes": [], "created": "2021-05-29T15:42:16.272Z", "modified": "2021-05-29T15:42:16.294Z"}, {"entity": "publication", "iuid": "ecfb81283b8d4464a1a186821f9831ab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ecfb81283b8d4464a1a186821f9831ab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ecfb81283b8d4464a1a186821f9831ab"}}, "title": "Mathematical modeling suggests pre-existing immunity to SARS-CoV-2", "authors": [{"family": "Carlsson", "given": "Marcus", "initials": "M"}, {"family": "Hatem", "given": "Gad", "initials": "G"}, {"family": "Soderberg-Naucler", "given": "Cecilia", "initials": "C"}], "type": "posted-content", "published": "2021-04-27", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.21.21255782", "pmid": null, "labels": {"Type: Preprint": null, "Category: Other": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-29T16:15:48.609Z", "modified": "2021-04-30T13:02:19.665Z"}, {"entity": "publication", "iuid": "d4848d32e81845a799c9c4615ed3dc81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4848d32e81845a799c9c4615ed3dc81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4848d32e81845a799c9c4615ed3dc81"}}, "title": "A combination of N and S antigens with IgA and IgG measurement strengthens the accuracy of SARS-CoV-2 serodiagnostics", "authors": [{"family": "Jalkanen", "given": "Pinja", "initials": "P"}, {"family": "Pasternack", "given": "Arja", "initials": "A"}, {"family": "Maljanen", "given": "Sari", "initials": "S"}, {"family": "Mel\u00e9n", "given": "Krister", "initials": "K"}, {"family": "Kolehmainen", "given": "Pekka", "initials": "P"}, {"family": "Huttunen", "given": "Moona", "initials": "M"}, {"family": "Lundberg", "given": "Rickard", "initials": "R"}, {"family": "Tripathi", "given": "Lav", "initials": "L"}, {"family": "Khan", "given": "Hira", "initials": "H"}, {"family": "Ritvos", "given": "Mikael A", "initials": "MA"}, {"family": "Naves", "given": "Rauno", "initials": "R"}, {"family": "Haveri", "given": "Anu", "initials": "A"}, {"family": "\u00d6sterlund", "given": "Pamela", "initials": "P"}, {"family": "Kuivanen", "given": "Suvi", "initials": "S"}, {"family": "J\u00e4\u00e4skel\u00e4inen", "given": "Anne J", "initials": "AJ"}, {"family": "Kurkela", "given": "Satu", "initials": "S"}, {"family": "Lappalainen", "given": "Maija", "initials": "M"}, {"family": "Rantas\u00e4rkk\u00e4", "given": "Kaisa", "initials": "K"}, {"family": "Vuorinen", "given": "Tytti", "initials": "T"}, {"family": "Hyt\u00f6nen", "given": "Jukka", "initials": "J"}, {"family": "Waris", "given": "Matti", "initials": "M"}, {"family": "Tauriainen", "given": "Sisko", "initials": "S"}, {"family": "Ritvos", "given": "Olli", "initials": "O"}, {"family": "Kakkola", "given": "Laura", "initials": "L"}, {"family": "Julkunen", "given": "Ilkka", "initials": "I"}], "type": "journal-article", "published": "2021-04-27", "journal": {"title": "The Journal of Infectious Diseases", "issn": "0022-1899", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1093/infdis/jiab222", "pmid": null, "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-29T10:13:44.262Z", "modified": "2021-04-29T10:15:16.292Z"}, {"entity": "publication", "iuid": "4b46fb9b6a364fffb0cdb5048b5d59ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b46fb9b6a364fffb0cdb5048b5d59ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b46fb9b6a364fffb0cdb5048b5d59ca"}}, "title": "When face-to-face interviews are not possible: tips and tricks for video, telephone, online chat, and email interviews in qualitative research.", "authors": [{"family": "Saarij\u00e4rvi", "given": "Markus", "initials": "M"}, {"family": "Bratt", "given": "Ewa-Lena", "initials": "EL"}], "type": "journal article", "published": "2021-04-24", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "volume": null, "issue": null, "issn-l": null}, "abstract": "Face-to-face interviews have long been the norm for conducting qualitative interviews in healthcare research. However, the Covid-19 pandemic has accelerated the need to explore alternative methods. This, along with the swift digitalization of healthcare, has led to video, telephone, and online interactions becoming increasingly used. The use of new techniques to carry out interviews through video, telephone, and online applications all come with benefits and drawbacks. In this article, three ways of collecting data through qualitative interviews are described and their uses exemplified through a project investigating the impact of a transition program for adolescents with congenital heart disease.", "doi": "10.1093/eurjcn/zvab038", "pmid": "33893797", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "6249551"}], "notes": [], "created": "2021-04-29T15:29:20.298Z", "modified": "2021-04-29T15:29:20.308Z"}, {"entity": "publication", "iuid": "2829e953fc844de68b4eabeba69828f6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2829e953fc844de68b4eabeba69828f6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2829e953fc844de68b4eabeba69828f6"}}, "title": "SARS-CoV-2 rapid antigen test: High sensitivity to detect infectious virus.", "authors": [{"family": "Nordgren", "given": "Johan", "initials": "J"}, {"family": "Sharma", "given": "Sumit", "initials": "S"}, {"family": "Olsson", "given": "Henrik", "initials": "H"}, {"family": "J\u00e4mtberg", "given": "Mikael", "initials": "M"}, {"family": "Falkeborn", "given": "Tina", "initials": "T"}, {"family": "Svensson", "given": "Lennart", "initials": "L"}, {"family": "Hagbom", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2021-04-24", "journal": {"title": "J Clin Virol", "issn": "1873-5967", "volume": "140", "issue": null, "pages": "104846", "issn-l": null}, "abstract": "The COVID-19 pandemic has highlighted the need for rapid, cost effective and easy-to-use diagnostic tools for SARS-CoV-2 infections that can be used in point of care settings to limit disease transmission.\n\nWe evaluated two rapid antigen immunochromatographic tests, Abbott Panbio\u2122 COVID-19 Ag Rapid Test (Panbio) and Zhejiang Orient Gene/Healgen Biotech Coronavirus Ag rapid test cassette (Orient gene) for detection of infectious SARS-CoV-2.\n\nThe tests were evaluated on nasopharyngeal samples taken from individuals having respiratory and/or COVID-19 related symptoms, which had been analyzed for SARS-CoV-2 RNA using real-time PCR. In total 156 PCR-positive, and 130 (Panbio) and 176 (Orient Gene) PCR-negative samples were analyzed. Overall sensitivity and specificity were 71.8% and 100% for Panbio and 79.5% and 74.4% for the Orient Gene test respectively. The false positives by the Orient Gene test were verified as SARS-CoV-2 negative by in-house real-time PCR assay and were negative for the four seasonal coronaviruses. Subgroup analysis revealed that the antigen tests had high sensitivity for samples with Ct-values <25 (>88%) and for samples containing infectious viruses as determined by cultivation on Vero cells, 94.1% and 97.1% for the Panbio and Orient gene tests, respectively. Furthermore, both tests had a sensitivity of <50 picogram for nucleocapsid protein. No sample with a Ct-value >27 was shown to contain infectious virus.\n\nThe results indicate that the rapid antigen tests, especially the Panbio tests may be a valuable tool to detect contagious persons during the ongoing pandemic.", "doi": "10.1016/j.jcv.2021.104846", "pmid": "33971580", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Serology": null}, "xrefs": [{"db": "pii", "key": "S1386-6532(21)00113-X"}, {"db": "pmc", "key": "PMC8105081"}], "notes": [], "created": "2021-05-17T18:59:51.442Z", "modified": "2021-05-17T19:00:05.499Z"}, {"entity": "publication", "iuid": "049415536c104aac889ad2589eb7e290", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/049415536c104aac889ad2589eb7e290.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/049415536c104aac889ad2589eb7e290"}}, "title": "Post-COVID syndrome: Need to include risk of addiction in research and multi-disciplinary clinical work.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "letter", "published": "2021-04-24", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "issn-l": null, "volume": "301", "issue": null, "pages": "113961"}, "abstract": null, "doi": "10.1016/j.psychres.2021.113961", "pmid": "33957379", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(21)00258-4"}, {"db": "pmc", "key": "PMC8064891"}], "notes": [], "created": "2021-05-17T19:06:00.630Z", "modified": "2021-07-02T14:28:42.169Z"}, {"entity": "publication", "iuid": "a8d2f9e9aefb4fca8d9c02c651aecb50", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8d2f9e9aefb4fca8d9c02c651aecb50.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8d2f9e9aefb4fca8d9c02c651aecb50"}}, "title": "Cyanobacteria-From the Oceans to the Potential Biotechnological and Biomedical Applications.", "authors": [{"family": "Khalifa", "given": "Shaden A M", "initials": "SAM"}, {"family": "Shedid", "given": "Eslam S", "initials": "ES"}, {"family": "Saied", "given": "Essa M", "initials": "EM"}, {"family": "Jassbi", "given": "Amir Reza", "initials": "AR"}, {"family": "Jamebozorgi", "given": "Fatemeh H", "initials": "FH"}, {"family": "Rateb", "given": "Mostafa E", "initials": "ME"}, {"family": "Du", "given": "Ming", "initials": "M"}, {"family": "Abdel-Daim", "given": "Mohamed M", "initials": "MM"}, {"family": "Kai", "given": "Guo-Yin", "initials": "GY"}, {"family": "Al-Hammady", "given": "Montaser A M", "initials": "MAM"}, {"family": "Xiao", "given": "Jianbo", "initials": "J"}, {"family": "Guo", "given": "Zhiming", "initials": "Z"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}], "type": "journal article", "published": "2021-04-24", "journal": {"title": "Mar Drugs", "issn": "1660-3397", "volume": "19", "issue": "5", "issn-l": null}, "abstract": "Cyanobacteria are photosynthetic prokaryotic organisms which represent a significant source of novel, bioactive, secondary metabolites, and they are also considered an abundant source of bioactive compounds/drugs, such as dolastatin, cryptophycin 1, curacin toyocamycin, phytoalexin, cyanovirin-N and phycocyanin. Some of these compounds have displayed promising results in successful Phase I, II, III and IV clinical trials. Additionally, the cyanobacterial compounds applied to medical research have demonstrated an exciting future with great potential to be developed into new medicines. Most of these compounds have exhibited strong pharmacological activities, including neurotoxicity, cytotoxicity and antiviral activity against HCMV, HSV-1, HHV-6 and HIV-1, so these metabolites could be promising candidates for COVID-19 treatment. Therefore, the effective large-scale production of natural marine products through synthesis is important for resolving the existing issues associated with chemical isolation, including small yields, and may be necessary to better investigate their biological activities. Herein, we highlight the total synthesized and stereochemical determinations of the cyanobacterial bioactive compounds. Furthermore, this review primarily focuses on the biotechnological applications of cyanobacteria, including applications as cosmetics, food supplements, and the nanobiotechnological applications of cyanobacterial bioactive compounds in potential medicinal applications for various human diseases are discussed.", "doi": "10.3390/md19050241", "pmid": "33923369", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "md19050241"}], "notes": [], "created": "2021-05-04T16:23:54.908Z", "modified": "2021-05-04T16:23:54.929Z"}, {"entity": "publication", "iuid": "3cffa71e6f75463d8f3f0744bccf3afb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3cffa71e6f75463d8f3f0744bccf3afb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3cffa71e6f75463d8f3f0744bccf3afb"}}, "title": "Call for a pan-European COVID-19 response must be comprehensive - Authors' reply.", "authors": [{"family": "Priesemann", "given": "Viola", "initials": "V"}, {"family": "Brinkmann", "given": "Melanie M", "initials": "MM"}, {"family": "Ciesek", "given": "Sandra", "initials": "S"}, {"family": "Cuschieri", "given": "Sarah", "initials": "S"}, {"family": "Czypionka", "given": "Thomas", "initials": "T"}, {"family": "Giordano", "given": "Giulia", "initials": "G"}, {"family": "Hanson", "given": "Claudia", "initials": "C"}, {"family": "Hens", "given": "Niel", "initials": "N"}, {"family": "Iftekhar", "given": "Emil", "initials": "E"}, {"family": "Klimek", "given": "Peter", "initials": "P"}, {"family": "Kretzschmar", "given": "Mirjam", "initials": "M"}, {"family": "Peichl", "given": "Andreas", "initials": "A"}, {"family": "Perc", "given": "Matja\u017e", "initials": "M"}, {"family": "Sannino", "given": "Francesco", "initials": "F"}, {"family": "Schernhammer", "given": "Eva", "initials": "E"}, {"family": "Schmidt", "given": "Alexander", "initials": "A"}, {"family": "Staines", "given": "Anthony", "initials": "A"}, {"family": "Szczurek", "given": "Ewa", "initials": "E"}], "type": "letter", "published": "2021-04-24", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "397", "issue": "10284", "pages": "1541", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(21)00462-1", "pmid": "33894827", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)00462-1"}], "notes": [], "created": "2021-04-29T15:28:23.486Z", "modified": "2021-04-29T15:28:42.254Z"}, {"entity": "publication", "iuid": "985d6927c03444debef535dd9f32fad3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/985d6927c03444debef535dd9f32fad3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/985d6927c03444debef535dd9f32fad3"}}, "title": "Epidemiological analysis of 3,219 COVID-19 outbreaks in the state of Baden-Wuerttemberg, Germany.", "authors": [{"family": "Dressler", "given": "Aparna", "initials": "A"}, {"family": "Finci", "given": "Iris", "initials": "I"}, {"family": "Wagner-Wiening", "given": "Christiane", "initials": "C"}, {"family": "Eichner", "given": "Martin", "initials": "M"}, {"family": "Brockmann", "given": "Stefan O", "initials": "SO"}], "type": "journal article", "published": "2021-04-23", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "issn-l": null, "volume": null, "issue": null, "pages": "1-18"}, "abstract": null, "doi": "10.1017/S0950268821000911", "pmid": "33888172", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0950268821000911"}], "notes": [], "created": "2021-04-29T16:11:39.530Z", "modified": "2021-04-29T16:32:25.071Z"}, {"entity": "publication", "iuid": "0bc38cc4b8e84a82a44e04503c54065a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0bc38cc4b8e84a82a44e04503c54065a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0bc38cc4b8e84a82a44e04503c54065a"}}, "title": "COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system.", "authors": [{"family": "Rysz", "given": "Susanne", "initials": "S"}, {"family": "Al-Saadi", "given": "Jonathan", "initials": "J"}, {"family": "Sj\u00f6str\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Farm", "given": "Maria", "initials": "M"}, {"family": "Campoccia Jalde", "given": "Francesca", "initials": "F"}, {"family": "Platt\u00e9n", "given": "Michael6", "initials": "M"}, {"family": "Eriksson", "given": "Helen", "initials": "H"}, {"family": "Klein", "given": "Margareta", "initials": "M"}, {"family": "Vargas-Paris", "given": "Roberto", "initials": "R"}, {"family": "Nyr\u00e9n", "given": "Sven", "initials": "S"}, {"family": "Abdula", "given": "Goran", "initials": "G"}, {"family": "Ouellette", "given": "Russell", "initials": "R"}, {"family": "Granberg", "given": "Tobias", "initials": "T"}, {"family": "Jonsson Fagerlund", "given": "Malin", "initials": "M"}, {"family": "Lundberg", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2021-04-23", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "2417"}, "abstract": "SARS-CoV-2 uses ACE2, an inhibitor of the Renin-Angiotensin-Aldosterone System (RAAS), for cellular entry. Studies indicate that RAAS imbalance worsens the prognosis in COVID-19. We present a consecutive retrospective COVID-19 cohort with findings of frequent pulmonary thromboembolism (17%), high pulmonary artery pressure (60%) and lung MRI perfusion disturbances. We demonstrate, in swine, that infusing angiotensin II or blocking ACE2 induces increased pulmonary artery pressure, reduces blood oxygenation, increases coagulation, disturbs lung perfusion, induces diffuse alveolar damage, and acute tubular necrosis compared to control animals. We further demonstrate that this imbalanced state can be ameliorated by infusion of an angiotensin receptor blocker and low-molecular-weight heparin. In this work, we show that a pathophysiological state in swine induced by RAAS imbalance shares several features with the clinical COVID-19 presentation. Therefore, we propose that severe COVID-19 could partially be driven by a RAAS imbalance.", "doi": "10.1038/s41467-021-22713-z", "pmid": "33893295", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-22713-z"}], "notes": [], "created": "2021-04-26T17:40:04.765Z", "modified": "2021-04-29T15:33:57.903Z"}, {"entity": "publication", "iuid": "0efcd0187d4f4c129e1c179bfb5452d8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0efcd0187d4f4c129e1c179bfb5452d8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0efcd0187d4f4c129e1c179bfb5452d8"}}, "title": "Meal and Sleep Timing before and during the COVID-19 Pandemic: A Cross-Sectional Anonymous Survey Study from Sweden.", "authors": [{"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Brand\u00e3o", "given": "Luiz Eduardo Mateus", "initials": "LEM"}, {"family": "Merikanto", "given": "Ilona", "initials": "I"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J"}], "type": "journal article", "published": "2021-04-22", "journal": {"title": "Clocks Sleep", "issn": "2624-5175", "volume": "3", "issue": "2", "pages": "251-258", "issn-l": null}, "abstract": "The COVID-19 pandemic and related restrictions, such as stay-at-home-orders, have significantly altered daily routines and lifestyles. Given their importance for metabolic health, we herein compared sleep and meal timing parameters during vs. before the COVID-19 pandemic based on subjective recall, in an anonymous Swedish survey. Among 191 adults (mean age: 47 years; 77.5% females), we show that social jetlag, i.e., the mismatch in sleep midpoint between work and free days, was reduced by about 17 min during the pandemic compared with the pre-pandemic state ( p < 0.001). Concomitantly, respondents' sleep midpoint was shifted toward morning hours during workdays (p < 0.001). A later daily eating midpoint accompanied the shift in sleep timing (p = 0.001). This effect was mainly driven by a later scheduled first meal (p < 0.001). No difference in the timing of the day's last meal was found (p = 0.814). Although our survey was limited in terms of sample size and by being cross-sectional, our results suggest that the delay in sleep timing due to the COVID-19 pandemic was accompanied by a corresponding shift in the timing of early but not late meals.", "doi": "10.3390/clockssleep3020015", "pmid": "33921946", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "clockssleep3020015"}], "notes": [], "created": "2021-05-04T16:24:15.921Z", "modified": "2021-05-04T16:24:15.944Z"}, {"entity": "publication", "iuid": "6e1f6b9ec31a455083dcfdd8f136d90d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e1f6b9ec31a455083dcfdd8f136d90d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e1f6b9ec31a455083dcfdd8f136d90d"}}, "title": "Making Waves: Collaboration in the time of SARS-CoV-2 - rapid development of an international co-operation and wastewater surveillance database to support public health decision-making.", "authors": [{"family": "Lundy", "given": "Lian", "initials": "L"}, {"family": "Fatta-Kassinos", "given": "Despo", "initials": "D"}, {"family": "Slobodnik", "given": "Jaroslav", "initials": "J"}, {"family": "Karaolia", "given": "Popi", "initials": "P"}, {"family": "Cirka", "given": "Lubos", "initials": "L"}, {"family": "Kreuzinger", "given": "Norbert", "initials": "N"}, {"family": "Castiglioni", "given": "Sara", "initials": "S"}, {"family": "Bijlsma", "given": "Lubertus", "initials": "L"}, {"family": "Dulio", "given": "Valeria", "initials": "V"}, {"family": "Deviller", "given": "Genevi\u00e8ve", "initials": "G"}, {"family": "Lai", "given": "Foon Yin", "initials": "FY"}, {"family": "Alygizakis", "given": "Nikiforos", "initials": "N"}, {"family": "Barneo", "given": "Manuela", "initials": "M"}, {"family": "Baz-Lomba", "given": "Jose Antonio", "initials": "JA"}, {"family": "B\u00e9en", "given": "Frederic", "initials": "F"}, {"family": "C\u00edchov\u00e1", "given": "Marianna", "initials": "M"}, {"family": "Conde-P\u00e9rez", "given": "Kelly", "initials": "K"}, {"family": "Covaci", "given": "Adrian", "initials": "A"}, {"family": "Donner", "given": "Erica", "initials": "E"}, {"family": "Ficek", "given": "Andrej", "initials": "A"}, {"family": "Hassard", "given": "Francis", "initials": "F"}, {"family": "Hedstr\u00f6m", "given": "Annelie", "initials": "A"}, {"family": "Hernandez", "given": "F\u00e9lix", "initials": "F"}, {"family": "Jansk\u00e1", "given": "Veronika", "initials": "V"}, {"family": "Jellison", "given": "Kristen", "initials": "K"}, {"family": "Hofman", "given": "Jan", "initials": "J"}, {"family": "Hill", "given": "Kelly", "initials": "K"}, {"family": "Hong", "given": "Pei-Ying", "initials": "P"}, {"family": "Kasprzyk-Hordern", "given": "Barbara", "initials": "B"}, {"family": "Kolarevi\u0107", "given": "Stoimir", "initials": "S"}, {"family": "Krahulec", "given": "Jan", "initials": "J"}, {"family": "Lambropoulou", "given": "Dimitra", "initials": "D"}, {"family": "de Llanos", "given": "Rosa", "initials": "R"}, {"family": "Macku\u013eak", "given": "Tom\u00e1\u0161", "initials": "T"}, {"family": "Martinez-Garc\u00eda", "given": "Lorena", "initials": "L"}, {"family": "Mart\u00ednez", "given": "Francisco", "initials": "F"}, {"family": "Medema", "given": "Gertjan", "initials": "G"}, {"family": "Micsinai", "given": "Adrienn", "initials": "A"}, {"family": "Myrmel", "given": "Mette", "initials": "M"}, {"family": "Nasser", "given": "Mohammed", "initials": "M"}, {"family": "Niederst\u00e4tter", "given": "Harald", "initials": "H"}, {"family": "Nozal", "given": "Leonor", "initials": "L"}, {"family": "Oberacher", "given": "Herbert", "initials": "H"}, {"family": "O\u010den\u00e1\u0161kov\u00e1", "given": "V\u011bra", "initials": "V"}, {"family": "Ogorzaly", "given": "Leslie", "initials": "L"}, {"family": "Papadopoulos", "given": "Dimitrios", "initials": "D"}, {"family": "Peinado", "given": "Beatriz", "initials": "B"}, {"family": "Pitk\u00e4nen", "given": "Tarja", "initials": "T"}, {"family": "Poza", "given": "Margarita", "initials": "M"}, {"family": "Rumbo-Feal", "given": "Soraya", "initials": "S"}, {"family": "S\u00e1nchez", "given": "Maria Blanca", "initials": "MB"}, {"family": "Sz\u00e9kely", "given": "Anna J", "initials": "AJ"}, {"family": "Soltysova", "given": "Andrea", "initials": "A"}, {"family": "Thomaidis", "given": "Nikolaos S", "initials": "NS"}, {"family": "Vallejo", "given": "Juan", "initials": "J"}, {"family": "van Nuijs", "given": "Alexander", "initials": "A"}, {"family": "Ware", "given": "Vassie", "initials": "V"}, {"family": "Viklander", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-04-22", "journal": {"title": "Water Res", "issn": "1879-2448", "issn-l": "0043-1354", "volume": "199", "issue": null, "pages": "117167"}, "abstract": "The presence of SARS-CoV-2 RNA in wastewater was first reported in March 2020. Over the subsequent months, the potential for wastewater surveillance to contribute to COVID-19 mitigation programmes has been the focus of intense national and international research activities, gaining the attention of policy makers and the public. As a new application of an established methodology, focused collaboration between public health practitioners and wastewater researchers is essential to developing a common understanding on how, when and where the outputs of this non-invasive community-level approach can deliver actionable outcomes for public health authorities. Within this context, the NORMAN SCORE \"SARS-CoV-2 in sewage\" database provides a platform for rapid, open access data sharing, validated by the uploading of 276 data sets from nine countries to-date. Through offering direct access to underpinning meta-data sets (and describing its use in data interpretation), the NORMAN SCORE database is a resource for the development of recommendations on minimum data requirements for wastewater pathogen surveillance. It is also a tool to engage public health practitioners in discussions on use of the approach, providing an opportunity to build mutual understanding of the demand and supply for data and facilitate the translation of this promising research application into public health practice.", "doi": "10.1016/j.watres.2021.117167", "pmid": "34015748", "labels": {"Type: Review": null, "Funder: Vinnova": null}, "xrefs": [{"db": "pii", "key": "S0043-1354(21)00365-1"}], "notes": [], "created": "2021-05-21T17:15:44.041Z", "modified": "2021-05-21T17:24:41.177Z"}, {"entity": "publication", "iuid": "8df82413871348eeb0566de94cc812a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8df82413871348eeb0566de94cc812a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8df82413871348eeb0566de94cc812a0"}}, "title": "Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial.", "authors": [{"family": "Gunst", "given": "Jesper D", "initials": "JD"}, {"family": "Staerke", "given": "Nina B", "initials": "NB"}, {"family": "Pahus", "given": "Marie H", "initials": "MH"}, {"family": "Kristensen", "given": "Lena H", "initials": "LH"}, {"family": "Bodilsen", "given": "Jacob", "initials": "J"}, {"family": "Lohse", "given": "Nicolai", "initials": "N"}, {"family": "Dalgaard", "given": "Lars S", "initials": "LS"}, {"family": "Br\u00f8nnum", "given": "Dorthe", "initials": "D"}, {"family": "Fr\u00f6bert", "given": "Ole", "initials": "O"}, {"family": "H\u00f8nge", "given": "Bo", "initials": "B"}, {"family": "Johansen", "given": "Isik S", "initials": "IS"}, {"family": "Monrad", "given": "Ida", "initials": "I"}, {"family": "Erikstrup", "given": "Christian", "initials": "C"}, {"family": "Rosendal", "given": "Regitze", "initials": "R"}, {"family": "Vilstrup", "given": "Emil", "initials": "E"}, {"family": "Mariager", "given": "Theis", "initials": "T"}, {"family": "Bove", "given": "Dorthe G", "initials": "DG"}, {"family": "Offersen", "given": "Rasmus", "initials": "R"}, {"family": "Shakar", "given": "Shakil", "initials": "S"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "J\u00f8rgensen", "given": "Nis P", "initials": "NP"}, {"family": "Sritharan", "given": "Sajitha S", "initials": "SS"}, {"family": "Breining", "given": "Peter", "initials": "P"}, {"family": "Jespersen", "given": "S\u00f8ren", "initials": "S"}, {"family": "Mortensen", "given": "Klaus L", "initials": "KL"}, {"family": "Jensen", "given": "Mads L", "initials": "ML"}, {"family": "Kolte", "given": "Lilian", "initials": "L"}, {"family": "Frattari", "given": "Giacomo S", "initials": "GS"}, {"family": "Larsen", "given": "Carsten S", "initials": "CS"}, {"family": "Storgaard", "given": "Merete", "initials": "M"}, {"family": "Nielsen", "given": "Lars P", "initials": "LP"}, {"family": "Tolstrup", "given": "Martin", "initials": "M"}, {"family": "S\u00e6dder", "given": "Eva A", "initials": "EA"}, {"family": "\u00d8stergaard", "given": "Lars J", "initials": "LJ"}, {"family": "Ngo", "given": "Hien T T", "initials": "HTT"}, {"family": "Jensen", "given": "Morten H", "initials": "MH"}, {"family": "H\u00f8jen", "given": "Jesper F", "initials": "JF"}, {"family": "Kjolby", "given": "Mads", "initials": "M"}, {"family": "S\u00f8gaard", "given": "Ole S", "initials": "OS"}], "type": "journal article", "published": "2021-04-22", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": null, "issue": null, "pages": "100849", "issn-l": null}, "abstract": "The trans-membrane protease serine 2 (TMPRSS2) is essential for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry and infection. Efficacy and safety of TMPRSS2 inhibitors in patients with coronavirus disease 2019 (Covid-19) have not been evaluated in randomized trials.\n\nWe conducted an investigator-initiated, double-blind, randomized, placebo-controlled multicenter trial in patients hospitalized with confirmed SARS-CoV-2 infection from April 4, to December 31, 2020. Within 48 h of admission, participants were randomly assigned in a 2:1 ratio to receive the TMPRSS2 inhibitor camostat mesilate 200 mg three times daily for 5 days or placebo. The primary outcome was time to discharge or clinical improvement measured as \u22652 points improvement on a 7-point ordinal scale. Other outcomes included 30-day mortality, safety and change in oropharyngeal viral load. ClinicalTrials.gov Identifier: NCT04321096. EudraCT Number: 2020-001,200-42.\n\n137 patients were assigned to receive camostat mesilate and 68 to placebo. Median time to clinical improvement was 5 days (interquartile range [IQR], 3 to 7) in the camostat group and 5 days (IQR, 2 to 10) in the placebo group ( P = 0\u00b731). The hazard ratio for 30-day mortality in the camostat compared with the placebo group was 0\u00b782 (95% confidence interval [CI], 0\u00b724 to 2\u00b779; P = 0\u00b775). The frequency of adverse events was similar in the two groups. Median change in viral load from baseline to day 5 in the camostat group was -0\u00b722 log10 copies/mL (p <0\u00b705) and -0\u00b782 log10 in the placebo group (P <0\u00b705).\n\nUnder this protocol, camostat mesilate treatment was not associated with increased adverse events during hospitalization for Covid-19 and did not affect time to clinical improvement, progression to ICU admission or mortality.", "doi": "10.1016/j.eclinm.2021.100849", "pmid": "33903855", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(21)00129-2"}, {"db": "pmc", "key": "PMC8060682"}, {"db": "ClinicalTrials.gov", "key": "NCT04321096"}], "notes": [], "created": "2021-04-29T10:21:54.594Z", "modified": "2021-04-29T10:22:43.188Z"}, {"entity": "publication", "iuid": "5e8f9500ce5844da856060c74262a286", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e8f9500ce5844da856060c74262a286.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e8f9500ce5844da856060c74262a286"}}, "title": "Clinical outcomes and risk factors for COVID-19 among migrant populations in high-income countries: a systematic review.", "authors": [{"family": "Hayward", "given": "Sally E", "initials": "SE"}, {"family": "Deal", "given": "Anna", "initials": "A"}, {"family": "Cheng", "given": "Cherie", "initials": "C"}, {"family": "Crawshaw", "given": "Alison", "initials": "A"}, {"family": "Orcutt", "given": "Miriam", "initials": "M"}, {"family": "Vandrevala", "given": "Tushna F", "initials": "TF"}, {"family": "Norredam", "given": "Prof Marie", "initials": "PM"}, {"family": "Carballo", "given": "Manuel", "initials": "M"}, {"family": "Ciftci", "given": "Yusuf", "initials": "Y"}, {"family": "Requena-M\u00e9ndez", "given": "Ana", "initials": "A"}, {"family": "Greenaway", "given": "Chris", "initials": "C"}, {"family": "Carter", "given": "Jessica", "initials": "J"}, {"family": "Knights", "given": "Felicity", "initials": "F"}, {"family": "Mehrotra", "given": "Anushka", "initials": "A"}, {"family": "Seedat", "given": "Farah", "initials": "F"}, {"family": "Bozorgmehr", "given": "Prof Kayvan", "initials": "PK"}, {"family": "Veizis", "given": "Apostolos", "initials": "A"}, {"family": "Campos-Matos", "given": "Ines", "initials": "I"}, {"family": "Wurie", "given": "Fatima", "initials": "F"}, {"family": "McKee", "given": "Prof Martin", "initials": "PM"}, {"family": "Kumar", "given": "Prof Bernadette", "initials": "PB"}, {"family": "Hargreaves", "given": "Sally", "initials": "S"}, {"family": "ESCMID Study Group for Infections in Travellers and Migrants (ESGITM)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-04-22", "journal": {"title": "J Migr Health", "issn": "2666-6235", "issn-l": null, "volume": null, "issue": null, "pages": "100041"}, "abstract": "Migrants in high-income countries may be at increased risk of COVID-19 due to their health and social circumstances, yet the extent to which they are affected and their predisposing risk factors are not clearly understood. We did a systematic review to assess clinical outcomes of COVID-19 in migrant populations, indirect health and social impacts, and to determine key risk factors.\r\n\r\nWe did a systematic review following PRISMA guidelines (PROSPERO CRD42020222135). We searched multiple databases to 18/11/2020 for peer-reviewed and grey literature on migrants (foreign-born) and COVID-19 in 82 high-income countries. We used our international networks to source national datasets and grey literature. Data were extracted on primary outcomes (cases, hospitalisations, deaths) and we evaluated secondary outcomes on indirect health and social impacts and risk factors using narrative synthesis.\r\n\r\n3016 data sources were screened with 158 from 15 countries included in the analysis (35 data sources for primary outcomes: cases [21], hospitalisations [4]; deaths [15]; 123 for secondary outcomes). We found that migrants are at increased risk of infection and are disproportionately represented among COVID-19 cases. Available datasets suggest a similarly disproportionate representation of migrants in reported COVID-19 deaths, as well as increased all-cause mortality in migrants in some countries in 2020. Undocumented migrants, migrant health and care workers, and migrants housed in camps have been especially affected. Migrants experience risk factors including high-risk occupations, overcrowded accommodation, and barriers to healthcare including inadequate information, language barriers, and reduced entitlement.\r\n\r\nMigrants in high-income countries are at high risk of exposure to, and infection with, COVID-19. These data are of immediate relevance to national public health and policy responses to the pandemic. Robust data on testing uptake and clinical outcomes in migrants, and barriers and facilitators to COVID-19 vaccination, are urgently needed, alongside strengthening engagement with diverse migrant groups.", "doi": "10.1016/j.jmh.2021.100041", "pmid": "33903857", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2666-6235(21)00008-8"}, {"db": "pmc", "key": "PMC8061095"}], "notes": [], "created": "2021-04-29T10:21:10.252Z", "modified": "2021-07-14T07:44:19.630Z"}, {"entity": "publication", "iuid": "b21b195ee3fb4aa5bf014ac1781bed44", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b21b195ee3fb4aa5bf014ac1781bed44.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b21b195ee3fb4aa5bf014ac1781bed44"}}, "title": "COVID-19 in pregnancy - characteristics and outcomes of pregnant women admitted to hospital because of SARS-CoV-2 infection in the Nordic countries.", "authors": [{"family": "Engjom", "given": "Hilde", "initials": "H"}, {"family": "Aabakke", "given": "Anna Jm", "initials": "AJ"}, {"family": "Klungs\u00f8yr", "given": "Kari", "initials": "K"}, {"family": "Svanvik", "given": "Teresia", "initials": "T"}, {"family": "\u00c4yr\u00e4s", "given": "Outi", "initials": "O"}, {"family": "Jonasdottir", "given": "Eva", "initials": "E"}, {"family": "Thurn", "given": "Lars", "initials": "L"}, {"family": "Jones", "given": "Elin", "initials": "E"}, {"family": "Pettersson", "given": "Karin", "initials": "K"}, {"family": "Nyfl\u00f8t", "given": "Lill Trine", "initials": "LT"}, {"family": "Al-Zirqi", "given": "Iqbal", "initials": "I"}, {"family": "Vangen", "given": "Siri", "initials": "S"}, {"family": "J\u00fal\u00edusson", "given": "P\u00e9tur B", "initials": "PB"}, {"family": "K\u00e4ll\u00e9n", "given": "Karin", "initials": "K"}, {"family": "Gissler", "given": "Mika", "initials": "M"}, {"family": "Krebs", "given": "Lone", "initials": "L"}], "type": "journal article", "published": "2021-04-22", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": null, "issue": null, "issn-l": "0001-6349"}, "abstract": "Population-based studies about the consequences of SARS-CoV-2 infection (COVID-19) in pregnancy are few and have limited generalizability to the Nordic population and health care systems.\n\nThis study examines pregnant women with COVID-19 in the five Nordic countries. Pregnant women were included if they were admitted to hospital between March 1 and June 30, 2020 and had a positive SARS-CoV-2 PCR test 14 days or fewer prior to the admission. Cause of admission was classified as obstetric or COVID-19 related.\n\nIn the study areas, 214 pregnant women with a positive test were admitted to hospital, of which 56 women needed hospital care due to COVID-19. The risk of admission due to COVID-19 was 0.4 per 1000 deliveries in Denmark, Finland, and Norway and 3.8 per 1000 deliveries in the Swedish regions. Women hospitalized because of COVID-19 were more frequently obese (P < 0.001) and had migrant background (P < 0.001) compared to the total population of women who delivered in 2018. Twelve women (21.4%) needed intensive care. Among the 56 women admitted due to COVID-19, 48 women delivered 51 infants. Preterm delivery (n=12, 25%, P < 0.001) and cesarean delivery (n=21, 43,8%, P < 0.001) were more frequent in women with COVID-19 compared to the women who delivered in 2018. No maternal deaths, stillbirths or neonatal deaths were reported.\n\nThe risk of admission due to COVID-19 disease in pregnancy was low in the Nordic countries. A fifth of the women required intensive care and we observed higher rates of preterm and cesarean deliveries. National public health policies appear to have had an impact on the risk of admission due to severe COVID-19 disease in pregnancy. Nordic collaboration is important in collecting robust data and assessing rare outcomes.", "doi": "10.1111/aogs.14160", "pmid": "33885150", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-23T04:26:33.875Z", "modified": "2021-04-23T04:26:33.878Z"}, {"entity": "publication", "iuid": "0eccaa022fbb4b4b9097af6451d6dcfb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0eccaa022fbb4b4b9097af6451d6dcfb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0eccaa022fbb4b4b9097af6451d6dcfb"}}, "title": "The International Academy of Health Sciences Informatics (IAHSI): 2020 Report.", "authors": [{"family": "Haux", "given": "Reinhold", "initials": "R"}, {"family": "Ball", "given": "Marion J", "initials": "MJ"}, {"family": "Hersh", "given": "William R", "initials": "WR"}, {"family": "Huesing", "given": "Elaine", "initials": "E"}, {"family": "Kimura", "given": "Michio", "initials": "M"}, {"family": "Koch", "given": "Sabine", "initials": "S"}, {"family": "Martin-Sanchez", "given": "Fernando", "initials": "F"}, {"family": "Otero", "given": "Paula", "initials": "P"}], "type": "journal article", "published": "2021-04-21", "journal": {"title": "Yearb Med Inform", "issn": "2364-0502", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To summarize the major activities of the International Academy of Health Sciences Informatics (IAHSI) in the 2020 time period and to welcome its 2020 Class of Fellows.\r\n\r\nReport from the members of the Academy's Board.\r\n\r\nDue to the SARS-CoV-2 pandemic, both Plenary meetings in 2020 had to be organized as virtual meetings. Scientific discussions, focusing on mobilizing computable biomedical knowledge and on data standards and interoperability formed major parts of these meetings. A statement on the use of informatics in pandemic situations was elaborated and sent to the World Health Organization. A panel on data standards and interoperability started its work. 34 Fellows were welcomed in the 2020 Class of Fellows so that the Academy now consists of 179 members.\r\n\r\nThere was a shift from supporting to strategic activities in the Academy's work. After having achieved organizational stability, the Academy can now focus on its strategic work and so on its main objective.", "doi": "10.1055/s-0041-1726479", "pmid": "33882593", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-04-23T04:37:32.554Z", "modified": "2021-07-14T07:42:34.648Z"}, {"entity": "publication", "iuid": "58dc6579e3f346f29a8468c2230d99ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/58dc6579e3f346f29a8468c2230d99ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/58dc6579e3f346f29a8468c2230d99ca"}}, "title": "Opportunities and Challenges for the Next Phase of Enhanced Recovery After Surgery: A Review.", "authors": [{"family": "Ljungqvist", "given": "Olle", "initials": "O"}, {"family": "de Boer", "given": "Hans D", "initials": "HD"}, {"family": "Balfour", "given": "Angie", "initials": "A"}, {"family": "Fawcett", "given": "William J", "initials": "WJ"}, {"family": "Lobo", "given": "Dileep N", "initials": "DN"}, {"family": "Nelson", "given": "Gregg", "initials": "G"}, {"family": "Scott", "given": "Michael J", "initials": "MJ"}, {"family": "Wainwright", "given": "Thomas W", "initials": "TW"}, {"family": "Demartines", "given": "Nicolas", "initials": "N"}], "type": "journal article", "published": "2021-04-21", "journal": {"title": "JAMA Surg", "issn": "2168-6262", "volume": null, "issue": null, "issn-l": null}, "abstract": "Enhanced Recovery After Surgery (ERAS) is a global surgical quality improvement initiative now firmly entrenched within the field of perioperative care. Although ERAS is associated with significant clinical outcome improvements and cost savings in numerous surgical specialties, several opportunities and challenges deserve further discussion.\n\nUptake and implementation of ERAS Society guidelines, together with ERAS-related research, have increased exponentially since the inception of the ERAS movement. Opportunities to further improve patient outcomes include addressing frailty, optimizing nutrition, prehabilitation, correcting preoperative anemia, and improving uptake of ERAS worldwide, including in low- and middle-income countries. Challenges facing enhanced recovery today include implementation, carbohydrate loading, reversal of neuromuscular blockade, and bowel preparation. The COVID-19 pandemic poses both a challenge and an opportunity for ERAS.\n\nTo date, ERAS has achieved significant benefit for patients and health systems; however, improvements are still needed, particularly in the areas of patient optimization and systematic implementation. During this time of global crisis, the ERAS method of delivering care is required to take surgery and anesthesia to the next level and bring improvements in outcomes to both patients and health systems.", "doi": "10.1001/jamasurg.2021.0586", "pmid": "33881466", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "2778928"}], "notes": [], "created": "2021-04-23T04:39:04.745Z", "modified": "2021-04-23T04:39:04.767Z"}, {"entity": "publication", "iuid": "2531ed7bcaaa4d80b39e4f02c542c107", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2531ed7bcaaa4d80b39e4f02c542c107.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2531ed7bcaaa4d80b39e4f02c542c107"}}, "title": "Enhancing Safety During a Pandemic Using Virtual Care Remote Monitoring Technologies and UML Modeling.", "authors": [{"family": "Borycki", "given": "Elizabeth M", "initials": "EM"}, {"family": "Kushniruk", "given": "Andre W", "initials": "AW"}, {"family": "Kletke", "given": "Ryan", "initials": "R"}, {"family": "Vimarlund", "given": "Vivian", "initials": "V"}, {"family": "Senathirajah", "given": "Yalini", "initials": "Y"}, {"family": "Quintana", "given": "Yuri", "initials": "Y"}], "type": "journal article", "published": "2021-04-21", "journal": {"title": "Yearb Med Inform", "issn": "2364-0502", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "This paper describes a methodology for gathering requirements and early design of remote monitoring technology (RMT) for enhancing patient safety during pandemics using virtual care technologies. As pandemics such as COrona VIrus Disease (COVID-19) progress there is an increasing need for effective virtual care and RMT to support patient care while they are at home.\r\n\r\nThe authors describe their work in conducting literature reviews by searching PubMed.gov and the grey literature for articles, and government websites with guidelines describing the signs and symptoms of COVID-19, as well as the progression of the disease. The reviews focused on identifying gaps where RMT could be applied in novel ways and formed the basis for the subsequent modelling of use cases for applying RMT described in this paper.\r\n\r\nThe work was conducted in the context of a new Home of the Future laboratory which has been set up at the University of Victoria. The literature review led to the development of a number of object-oriented models for deploying RMT. This modeling is being used for a number of purposes, including for education of students in health infomatics as well as testing of new use cases for RMT with industrial collaborators and projects within the smart home of the future laboratory.\r\n\r\nObject-oriented modeling, based on analysis of gaps in the literature, was found to be a useful approach for describing, communicating and teaching about potential new uses of RMT.", "doi": "10.1055/s-0041-1726485", "pmid": "33882599", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-04-23T04:35:17.857Z", "modified": "2021-07-14T07:40:56.626Z"}, {"entity": "publication", "iuid": "c36b83f5047b46e28e2c5e70b287efd5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c36b83f5047b46e28e2c5e70b287efd5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c36b83f5047b46e28e2c5e70b287efd5"}}, "title": "Colorimetric isothermal nucleic acid detection of SARS-CoV-2 with dye combination.", "authors": [{"family": "Wu", "given": "Shanshan", "initials": "S"}, {"family": "Liu", "given": "Xiyang", "initials": "X"}, {"family": "Ye", "given": "Shenglong", "initials": "S"}, {"family": "Liu", "given": "Jianmin", "initials": "J"}, {"family": "Zheng", "given": "Wei", "initials": "W"}, {"family": "Dong", "given": "Xue", "initials": "X"}, {"family": "Yin", "given": "Xiushan", "initials": "X"}], "type": "journal article", "published": "2021-04-21", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": null, "issue": null, "pages": "e06886", "issn-l": null}, "abstract": "RT-LAMP detection of SARS-CoV-2 has been demonstrated to be a valuable diagnostic method for the diagnosis of COVID-19 1,2, which can rapidly screen carriers of the virus to effectively control the spread of the SARS-CoV-2. Here, we present a combination of dyes for isothermal detection of SARS-CoV-2 as a commercial alternative, with expanded colorimetric spectrum. We compared them with commercial reagents and proved their suitability and sensitivity through clinical RNA samples. In addition, together with commercial single dye indicators, we believe the expanded color spectrum developed here as an indicator of rapid detection will promote the diagnosis of COVID-19.", "doi": "10.1016/j.heliyon.2021.e06886", "pmid": "33903853", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)00989-0"}, {"db": "pmc", "key": "PMC8059943"}], "notes": [], "created": "2021-04-29T10:24:05.235Z", "modified": "2021-04-29T10:24:05.246Z"}, {"entity": "publication", "iuid": "a1dd881e061043cdbf6c5d279d0cd195", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a1dd881e061043cdbf6c5d279d0cd195.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a1dd881e061043cdbf6c5d279d0cd195"}}, "title": "Utilization of traditional medicine and its integration into the healthcare system in Qokolweni, South Africa; prospects for enhanced universal health coverage.", "authors": [{"family": "Mutola", "given": "Sianga", "initials": "S"}, {"family": "Pemunta", "given": "Ngambouk Vitalis", "initials": "NV"}, {"family": "Ngo", "given": "Ngo Valery", "initials": "NV"}], "type": "journal article", "published": "2021-04-20", "journal": {"title": "Complement Ther Clin Pract", "issn": "1873-6947", "issn-l": null, "volume": "43", "issue": null, "pages": "101386"}, "abstract": "Despite the WHO providing a framework for the integration of traditional medicines into the health systems with pandemics like HIV/AIDS and the COVID-19, most countries are yet to adopt the recommendations. This study explored why the integration of traditional medicines with the biomedical healthcare system in Qokolweni in Eastern Cape, South Africa was stalling. The research employed qualitative research methods; participant observation and in-depth ethnographic interviews of community members, traditional healers, and nurses. The study found that: traditional medicines are widely used in Qokolweni due to accessibility and long-built trust; the practice is broad and not certified. To achieve the integration of traditional medicine into the conventional health systems, the central government needs to show political will by setting up regulatory strategies that provide for the scientific evaluation and certification of traditional medicines. This will build confidence among biomedical scientists and health practitioners, thereby fostering easy collaboration and integration.", "doi": "10.1016/j.ctcp.2021.101386", "pmid": "33895465", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1744-3881(21)00085-2"}], "notes": [], "created": "2021-04-29T15:27:43.729Z", "modified": "2021-07-14T07:35:30.273Z"}, {"entity": "publication", "iuid": "0ca0ff0b36104042b3ab3ee645154f46", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ca0ff0b36104042b3ab3ee645154f46.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ca0ff0b36104042b3ab3ee645154f46"}}, "title": "SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses.", "authors": [{"family": "Mandolesi", "given": "Marco", "initials": "M"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Ma", "given": "Junjie", "initials": "J"}, {"family": "Pushparaj", "given": "Pradeepa", "initials": "P"}, {"family": "Perez Vidakovics", "given": "Laura", "initials": "L"}, {"family": "Kim", "given": "Changil", "initials": "C"}, {"family": "\u00c0dori", "given": "Monika", "initials": "M"}, {"family": "Lenart", "given": "Klara", "initials": "K"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "Castro Dopico", "given": "Xaquin", "initials": "X"}, {"family": "Coquet", "given": "Jonathan M", "initials": "JM"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Murrell", "given": "Ben", "initials": "B"}], "type": "journal article", "published": "2021-04-20", "journal": {"title": "Cell Rep Med", "issn": "2666-3791", "issn-l": "2666-3791", "volume": "2", "issue": "4", "pages": "100252"}, "abstract": "The outbreak and spread of SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2) is a current global health emergency, and effective prophylactic vaccines are needed urgently. The spike glycoprotein of SARS-CoV-2 mediates entry into host cells, and thus is the target of neutralizing antibodies. Here, we show that adjuvanted protein immunization with soluble SARS-CoV-2 spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaques, with neutralizing antibody titers exceeding those typically measured in SARS-CoV-2 seropositive humans by more than one order of magnitude. Neutralizing antibody responses were observed after a single dose, with exceptionally high titers achieved after boosting. A follow-up to monitor the waning of the neutralizing antibody responses in rhesus macaques demonstrated durable responses that were maintained at high and stable levels at least 4 months after boosting. These data support the development of adjuvanted SARS-CoV-2 prefusion-stabilized spike protein subunit vaccines.", "doi": "10.1016/j.xcrm.2021.100252", "pmid": "33842900", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Funder: H2020": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S2666-3791(21)00068-9"}, {"db": "pmc", "key": "PMC8020888"}], "notes": [], "created": "2021-04-13T09:35:47.773Z", "modified": "2021-09-27T12:29:50.595Z"}, {"entity": "publication", "iuid": "a05ae0b55843422eb39e3a7ea4e21182", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a05ae0b55843422eb39e3a7ea4e21182.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a05ae0b55843422eb39e3a7ea4e21182"}}, "title": "Internet-Related Behaviors and Psychological Distress Among Schoolchildren During the COVID-19 School Hiatus", "authors": [{"family": "Chen", "given": "Chao Ying", "initials": "CY"}, {"family": "Chen", "given": "I Hua", "initials": "IH"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Lin", "given": "Chung Ying", "initials": "CY"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}], "type": "journal-article", "published": "2021-04-20", "journal": {"title": "Cyberpsychology, Behavior, and Social Networking", "issn": "2152-2715", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1089/cyber.2020.0497", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-04-23T04:41:04.022Z", "modified": "2021-04-23T04:41:04.044Z"}, {"entity": "publication", "iuid": "6635da3d214446ccba6addfe21442f84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6635da3d214446ccba6addfe21442f84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6635da3d214446ccba6addfe21442f84"}}, "title": "Cell type resolved quantitative proteomics map of interferon response against SARS-CoV-2.", "authors": [{"family": "Saccon", "given": "Elisa", "initials": "E"}, {"family": "Chen", "given": "Xi", "initials": "X"}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "Rodriguez", "given": "Jimmy Esneider", "initials": "JE"}, {"family": "Szekely", "given": "Laszlo", "initials": "L"}, {"family": "Vinhas", "given": "Beatriz S\u00e1", "initials": "BS"}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}, {"family": "Frisan", "given": "Teresa", "initials": "T"}, {"family": "V\u00e9gv\u00e1ri", "given": "\u00c1kos", "initials": "\u00c1"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}, {"family": "Gupta", "given": "Soham", "initials": "S"}], "type": "journal article", "published": "2021-04-20", "journal": {"title": "iScience", "issn": "2589-0042", "issn-l": "2589-0042", "volume": "24", "issue": "5", "pages": "102420"}, "abstract": "The commonly used laboratory cell lines are the first line of experimental models to study the pathogenicity and performing antiviral assays for emerging viruses. Here, we assessed the tropism and cytopathogenicity of the first Swedish isolate of SARS-CoV-2 in six different human cell lines, compared their growth characteristics and performed quantitative proteomics for the susceptible cell lines. Overall, Calu-3, Caco2, Huh7, and 293FT cell lines showed a high to moderate level of susceptibility to SARS-CoV-2. In Caco2 cells the virus can achieve high titers in the absence of any prominent cytopathic effect. The protein abundance profile during SARS-CoV-2 infection revealed cell-type-specific regulation of cellular pathways. Type-I interferon signaling was identified as the common dysregulated cellular response in Caco2, Calu-3 and Huh7 cells. Together, our data shows cell-type specific variability for cytopathogenicity, susceptibility and cellular response to SARS-CoV-2 and provide important clues to guide future studies.", "doi": "10.1016/j.isci.2021.102420", "pmid": "33898942", "labels": {"Type: Journal article": null, "Funder: H2020": null, "Funder: VR": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(21)00388-6"}, {"db": "pmc", "key": "PMC8056843"}], "notes": [], "created": "2021-04-29T10:27:34.511Z", "modified": "2021-08-25T14:31:17.789Z"}, {"entity": "publication", "iuid": "7aa42797dd3049668c25bbdafe828ba2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7aa42797dd3049668c25bbdafe828ba2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7aa42797dd3049668c25bbdafe828ba2"}}, "title": "COVID-19 as the sole cause of death is uncommon in frail home healthcare individuals: a population-based study.", "authors": [{"family": "Nilsson", "given": "Lena", "initials": "L"}, {"family": "Andersson", "given": "Christer", "initials": "C"}, {"family": "Sj\u00f6dahl", "given": "Rune", "initials": "R"}], "type": "journal article", "published": "2021-04-20", "journal": {"title": "BMC Geriatr", "issn": "1471-2318", "issn-l": null, "volume": "21", "issue": "1", "pages": "262"}, "abstract": "During the first pandemic wave, Sweden experienced a high mortality rate. Home healthcare reflects a group of people especially vulnerable to coronavirus disease 2019 (COVID-19). We aimed to evaluate the pattern of comorbidity and frailty in a group of individuals having fatal outcomes in home healthcare during the COVID-19 pandemic March to September 2020, and to assess the contribution of COVID-19 in the fatal outcomes.\r\n\r\nA cohort of adults with confirmed COVID-19 diagnosis that deceased in home healthcare between March and September 2020 were analysed in a retrospective study comprising home healthcare in 136 facilities in one Swedish county. Main outcome measures were comorbidity and frailty.\r\n\r\nOne hundred fifty-five individuals (88 women, 67 men) aged 57-106 (median 88) years were included in the analysis. Nine had considerable frailty (ability to perform various activities of daily living but confined to bed or chair on occasion) and the remaining 146 had severe frailty (unable to perform activities of daily living and/or confined to bed or chair; dementia necessitating care). Three or more diagnoses besides COVID-19 were present in 142 individuals and another eight had two diagnoses in addition to COVID-19. In 20 (13%) individuals, COVID-19 was assessed as the principal cause of death, in 100 (64.5%) a contributing cause, and for the remaining 35 (22.5%) death was probably caused by another comorbidity. This seemed to change over the course of the COVID - 19 pandemic, with its contributing role decreasing from the middle of the summer.\r\n\r\nDeath in home healthcare during the first wave of the pandemic mostly affected individuals with severe frailty and comorbidity at very advanced ages. One fifth of the individuals who died in home health care had another cause than Covid-19.\r\n\r\nClinical Trials.gov NCT04642196 date 24/11/2020.", "doi": "10.1186/s12877-021-02176-z", "pmid": "33879078", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12877-021-02176-z"}, {"db": "ClinicalTrials.gov", "key": "NCT04642196"}], "notes": [], "created": "2021-04-23T04:39:25.834Z", "modified": "2021-07-14T07:38:36.859Z"}, {"entity": "publication", "iuid": "7b8ac0478dd64503b3ce0f6d32c35cfa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b8ac0478dd64503b3ce0f6d32c35cfa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b8ac0478dd64503b3ce0f6d32c35cfa"}}, "title": "COVID-19 and municipal solid waste (MSW) management: a review", "authors": [{"family": "Das", "given": "Atanu Kumar", "initials": "AK"}, {"family": "Islam", "given": "Md Nazrul", "initials": "MN"}, {"family": "Billah", "given": "Md Morsaline", "initials": "MM"}, {"family": "Sarker", "given": "Asim", "initials": "A"}], "type": "journal-article", "published": "2021-04-20", "journal": {"title": "Environ Sci Pollut Res", "issn": "0944-1344", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1007/s11356-021-13914-6", "pmid": null, "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-04-23T04:42:33.639Z", "modified": "2021-04-23T04:42:33.662Z"}, {"entity": "publication", "iuid": "71f835534d1d490792921196d40f951a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/71f835534d1d490792921196d40f951a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/71f835534d1d490792921196d40f951a"}}, "title": "A Multi-Criteria Framework for Pandemic Response Measures.", "authors": [{"family": "Ekenberg", "given": "Love", "initials": "L"}, {"family": "Mihai", "given": "Adriana", "initials": "A"}, {"family": "Fasth", "given": "Tobias", "initials": "T"}, {"family": "Komendantova", "given": "Nadejda", "initials": "N"}, {"family": "Danielson", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2021-04-20", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "issue": null, "pages": "583706", "issn-l": "2296-2565"}, "abstract": "In managing the COVID-19 pandemic, several compelling narratives seem to have played a significant role in the decision-making processes regarding which risk mitigation and management measures to implement. Many countries were to a large extent unprepared for such a situation, even though predictions about a significant probability for a pandemic to occur existed, and national governments of several countries often acted in an uncoordinated manner, which resulted in many inconsistencies in the disaster risk reduction processes. Limited evidence has also made room for strategic narratives meant to persuade the public of the chosen set of actions, even though the degree of uncertainty regarding the outcomes of these was high, further complicating the situation. In this article, we assume a normative standpoint regarding rhapsodic decision making and suggest an integrated framework for a more elaborated decision analysis under the ambiguity of how to contain the virus spread from a policy point of view, while considering epidemiologic estimations and socioeconomic factors in a multi-stakeholder-multi-criteria context based on a co-creative work process for eliciting attitudes, perceptions, as well as preferences amongst relevant stakeholder groups. The framework, applied in our paper on Romania for demonstrative purposes, is used for evaluating mitigation measures for catastrophic events such as the COVID-19 situation, to mobilize better response strategies for future scenarios related to pandemics and other hazardous events, as well as to structure the production and analysis of narratives on the current pandemic effects.", "doi": "10.3389/fpubh.2021.583706", "pmid": "33968871", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8096778"}], "notes": [], "created": "2021-05-17T19:03:26.840Z", "modified": "2021-05-17T19:03:26.852Z"}, {"entity": "publication", "iuid": "27ead992a7654577962986e6513c266b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27ead992a7654577962986e6513c266b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27ead992a7654577962986e6513c266b"}}, "title": "The Impact of Coronavirus (COVID-19) Related Public-Health Measures on Training Behaviours of Individuals Previously Participating in Resistance Training: A Cross-Sectional Survey Study", "authors": [{"family": "Steele", "given": "James", "initials": "J"}, {"family": "Androulakis-Korakakis", "given": "Patroklos", "initials": "P"}, {"family": "Carlson", "given": "Luke", "initials": "L"}, {"family": "Williams", "given": "David", "initials": "D"}, {"family": "Phillips", "given": "Stuart", "initials": "S"}, {"family": "Smith", "given": "Dave", "initials": "D"}, {"family": "Schoenfeld", "given": "Brad J", "initials": "BJ"}, {"family": "Loenneke", "given": "Jeremy P", "initials": "JP"}, {"family": "Winett", "given": "Richard", "initials": "R"}, {"family": "Abe", "given": "Takashi", "initials": "T"}, {"family": "Dufour", "given": "St\u00e9phane", "initials": "S"}, {"family": "Franchi", "given": "Martino V", "initials": "MV"}, {"family": "Sarto", "given": "Fabio", "initials": "F"}, {"family": "Lundberg", "given": "Tommy R", "initials": "TR"}, {"family": "Gentil", "given": "Paulo", "initials": "P"}, {"family": "Kvorning", "given": "Thue", "initials": "T"}, {"family": "Giessing", "given": "J\u00fcrgen", "initials": "J"}, {"family": "Sedliak", "given": "Milan", "initials": "M"}, {"family": "Paoli", "given": "Antonio", "initials": "A"}, {"family": "Spotswood", "given": "Fiona", "initials": "F"}, {"family": "Lucas", "given": "Alex", "initials": "A"}, {"family": "Fisher", "given": "James P", "initials": "JP"}], "type": "journal-article", "published": "2021-04-19", "journal": {"title": "Sports Med", "issn": "1179-2035", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": "Understanding the impact of lockdown upon resistance training (RT), and how people adapted their RT behaviours, has implications for strategies to maintain engagement in similar positive health behaviours. Further, doing so will provide a baseline for investigation of the long-term effects of these public health measures upon behaviours and perceptions, and facilitate future follow-up study.\r\n\r\nTo determine how the onset of coronavirus (COVID-19), and associated 'lockdown', affected RT behaviours, in addition to motivation, perceived effectiveness, enjoyment, and intent to continue, in those who regularly performed RT prior to the pandemic.\r\n\r\nWe conducted an observational, cross-sectional study using online surveys in multiple languages (English, Danish, French, German, Italian, Portuguese, Slovakian, Swedish, and Japanese) distributed across social media platforms and through authors' professional and personal networks. Adults (n = 5389; median age = 31 years [interquartile range (IQR) = 25, 38]), previously engaged in RT prior to lockdown (median prior RT experience = 7 years [IQR = 4, 12]) participated. Outcomes were self-reported RT behaviours including: continuation of RT during lockdown, location of RT, purchase of specific equipment for RT, method of training, full-body or split routine, types of training, repetition ranges, exercise number, set volumes (per exercise and muscle group), weekly frequency of training, perception of effort, whether training was planned/recorded, time of day, and training goals. Secondary outcomes included motivation, perceived effectiveness, enjoyment, and intent to continue RT.\r\n\r\nA majority of individuals (82.8%) maintained participation in RT during-lockdown. Marginal probabilities from generalised linear models and generalised estimating equations for RT behaviours were largely similar from pre- to during-lockdown. There was reduced probability of training in privately owned gyms (~ 59% to ~ 7%) and increased probability of training at home (~ 18% to ~ 89%); greater probability of training using a full-body routine (~ 38% to ~ 51%); reduced probability of resistance machines (~ 66% to ~ 13%) and free weight use (~ 96% to ~ 81%), and increased probability of bodyweight training (~ 62% to ~ 82%); reduced probability of moderate repetition ranges (~ 62-82% to ~ 55-66%) and greater probability of higher repetition ranges (~ 27% to ~ 49%); and moderate reduction in the perception of effort experienced during-training (r = 0.31). Further, individuals were slightly less likely to plan or record training during lockdown and many changed their training goals. Additionally, perceived effectiveness, enjoyment, and likelihood of continuing current training were all lower during-lockdown.\r\n\r\nThose engaged in RT prior to lockdown these behaviours with only slight adaptations in both location and types of training performed. However, people employed less effort, had lower motivation, and perceived training as less effective and enjoyable, reporting their likelihood of continuing current training was similar or lower than pre-lockdown. These results have implications for strategies to maintain engagement in positive health behaviours such as RT during-restrictive pandemic-related public health measures. PRE-REGISTRATION: https://osf.io/qcmpf .\r\n\r\nThe preprint version of this work is available on SportR\u03c7iv: https://osf.io/preprints/sportrxiv/b8s7e/ .", "doi": "10.1007/s40279-021-01438-5", "pmid": "33871831", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "URL", "key": "https://osf.io/xhryf/", "description": "Dataset: Survey data"}], "notes": [], "created": "2021-04-20T17:54:09.535Z", "modified": "2021-07-14T10:59:51.720Z"}, {"entity": "publication", "iuid": "104de2c0ff24467faa96e866ae338d06", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/104de2c0ff24467faa96e866ae338d06.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/104de2c0ff24467faa96e866ae338d06"}}, "title": "ECG with Prior Myocardial Infarction Pattern or acute ST-T Pathology is Associated with Death in Critically Ill COVID-19 Patients", "authors": [{"family": "Rosen", "given": "Jacob", "initials": "J"}, {"family": "Noreland", "given": "Maria", "initials": "M"}, {"family": "Stattin", "given": "Karl", "initials": "K"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Malinovschi", "given": "Andrei", "initials": "A"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}], "type": "posted-content", "published": "2021-04-19", "journal": {"title": "Research Square", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.21203/rs.3.rs-419853/v1", "pmid": null, "labels": {"Funder: VR": null, "Type: Preprint": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.17044/scilifelab.14229410.v1", "description": "Metadata record"}], "notes": [], "created": "2021-06-09T12:05:22.522Z", "modified": "2021-06-18T09:19:34.572Z"}, {"entity": "publication", "iuid": "3840116225c543e5a738388f958bb923", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3840116225c543e5a738388f958bb923.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3840116225c543e5a738388f958bb923"}}, "title": "Cause of death based on systematic postmortem studies in patients with positive SARS\u2010CoV2 tissue PCR during the COVID\u201019 pandemic", "authors": [{"family": "Romanova", "given": "Elena S", "initials": "ES"}, {"family": "Vasilyev", "given": "Valery V", "initials": "VV"}, {"family": "Startseva", "given": "Galina", "initials": "G"}, {"family": "Karev", "given": "Vadim", "initials": "V"}, {"family": "Rybakova", "given": "Margarita G", "initials": "MG"}, {"family": "Platonov", "given": "Pyotr G", "initials": "PG"}], "type": "journal-article", "published": "2021-04-19", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1111/joim.13300", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-20T17:53:20.904Z", "modified": "2021-04-20T17:53:20.921Z"}, {"entity": "publication", "iuid": "38bb5376ea5b44bea12092dbca89831b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38bb5376ea5b44bea12092dbca89831b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38bb5376ea5b44bea12092dbca89831b"}}, "title": "Why COVID-19 strengthens the case to scale up assault on non-communicable diseases: role of health professionals including physical therapists in mitigating pandemic waves.", "authors": [{"family": "Dean", "given": "Elizabeth", "initials": "E"}, {"family": "Skinner", "given": "Margot", "initials": "M"}, {"family": "Yu", "given": "Homer Peng-Ming", "initials": "HP"}, {"family": "Jones", "given": "Alice Ym", "initials": "AY"}, {"family": "Gosselink", "given": "Rik", "initials": "R"}, {"family": "S\u00f6derlund", "given": "Anne", "initials": "A"}], "type": "journal article", "published": "2021-04-16", "journal": {"title": "AIMS Public Health", "issn": "2327-8994", "volume": "8", "issue": "2", "pages": "369-375", "issn-l": null}, "abstract": "As SARS-CoV-2, the virus responsible for COVID-19, spread globally, the most severely affected sub-populations were the elderly and those with multi-morbidity largely related to non-communicable diseases (NCDs), e.g., heart disease, hypertension, type 2 diabetes, obesity. NCDs are largely preventable with healthy nutrition, regular activity, and not smoking. This perspective outlines the rationale for health professionals' including physical therapists' role in reducing COVID-19 susceptibility. Evidence is synthesized supporting the pro-inflammatory effects of the western diet, increasingly consumed globally, inactivity, and smoking; and the immune-boosting, anti-inflammatory effects of a whole food plant-based diet, regular physical activity, and not smoking. An increased background of chronic low-grade systemic inflammation associated with unhealthy lifestyle practices appears implicated in an individual's susceptibility to SARS-CoV-2. It is timely to re-double efforts across healthcare sectors to reduce the global prevalence of NCDs on two fronts: one, to reduce SARS-CoV-2 susceptibility; and two, to reduce the impact of subsequent waves given high blood pressure and blood sugar, common in people with multi-morbidity, can be improved within days/weeks with anti-inflammatory healthy lifestyle practices, and weight loss and atherosclerosis reduction/reversal, within months/years. With re-doubled efforts to control NCD risk factors, subsequent waves could be less severe. Health professionals including physical therapists have a primary role in actively leading this initiative.", "doi": "10.3934/publichealth.2021028", "pmid": "34017898", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "publichealth-08-02-028"}, {"db": "pmc", "key": "PMC8116194"}], "notes": [], "created": "2021-05-29T16:25:31.820Z", "modified": "2021-05-29T16:25:31.843Z"}, {"entity": "publication", "iuid": "f3ad0ee0464842b3ae6ef3b029d00a7f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f3ad0ee0464842b3ae6ef3b029d00a7f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f3ad0ee0464842b3ae6ef3b029d00a7f"}}, "title": "Vaccination against COVID-19: insight from arterial and venous thrombosis occurrence using data from VigiBase.", "authors": [{"family": "Smadja", "given": "David M", "initials": "DM"}, {"family": "Yue", "given": "Qun-Ying", "initials": "Q"}, {"family": "Chocron", "given": "Richard", "initials": "R"}, {"family": "Sanchez", "given": "Olivier", "initials": "O"}, {"family": "Lillo-Le Louet", "given": "Agnes", "initials": "A"}], "type": "letter", "published": "2021-04-16", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "issn-l": "0903-1936", "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1183/13993003.00956-2021", "pmid": "33863748", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "13993003.00956-2021"}], "notes": [], "created": "2021-04-19T10:39:09.176Z", "modified": "2021-04-29T16:33:21.674Z"}, {"entity": "publication", "iuid": "066372348ae8499fa8e4633f559b0634", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/066372348ae8499fa8e4633f559b0634.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/066372348ae8499fa8e4633f559b0634"}}, "title": "Continuous renal replacement therapy in intensive care patients with COVID-19; survival and renal recovery.", "authors": [{"family": "Eriksson", "given": "Karin E", "initials": "KE"}, {"family": "Campoccia-Jalde", "given": "Francesca", "initials": "F"}, {"family": "Rysz", "given": "Susanne", "initials": "S"}, {"family": "Rimes-Stigare", "given": "Claire", "initials": "C"}], "type": "journal article", "published": "2021-04-16", "journal": {"title": "J Crit Care", "issn": "1557-8615", "volume": "64", "issue": null, "pages": "125-130", "issn-l": "0883-9441"}, "abstract": "Outcome for critically ill patients with COVID-19 treated with continuous renal replacement therapy (CRRT) is largely unknown. We describe mortality and renal outcome in this group.\n\nThis observational study was conducted at a university hospital in Sweden. We studied critically ill adult COVID-19 patients with Acute Kidney injury (AKI) who received CRRT.\n\nIn 451 patients, AKI incidence was 43.7%. 18.2% received CRRT. Median age of CRRT patients was 60 years (IQR 54-65), 90% were male, median BMI was 29 (IQR 25-32), 23.2% had Diabetes, 37.8% hypertension and 6.1% chronic kidney disease prior to admission. 100% required mechanical ventilation. 8.5% received Extra Corporeal Membrane Oxygenation. Median length of stay was 23 days (IQR 15-26). ICU mortality was 39% and 90-day mortality was 45.1%. Age, baseline creatinine values and body weight change were associated with 60 days mortality. Of the survivors, no patients required dialysis at hospital discharge, 73.8% recovered renal function and a median 10.5% of body weight was lost during admission.\n\nCritically ill COVID-19 patients with AKI who received CRRT had a 90-day mortality of 45.1%. At follow-up, three quarters of survivors had recovered renal function. This information is important in the clinical management of COVID-19.", "doi": "10.1016/j.jcrc.2021.04.002", "pmid": "33878517", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0883-9441(21)00063-0"}, {"db": "pmc", "key": "PMC8052481"}], "notes": [], "created": "2021-04-23T04:40:30.388Z", "modified": "2021-04-23T04:40:30.399Z"}, {"entity": "publication", "iuid": "043e3c05fce449a0986615c8f2b88cd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/043e3c05fce449a0986615c8f2b88cd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/043e3c05fce449a0986615c8f2b88cd0"}}, "title": "Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials.", "authors": [{"family": "Axfors", "given": "Cathrine", "initials": "C"}, {"family": "Schmitt", "given": "Andreas M", "initials": "AM", "orcid": "0000-0002-9568-8164", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e04ff63fee604c08bb913012e4645bf6.json"}}, {"family": "Janiaud", "given": "Perrine", "initials": "P"}, {"family": "Van't Hooft", "given": "Janneke", "initials": "J", "orcid": "0000-0001-5303-1503", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d0cd2d5d4ae4c88bf5b3307e32869a8.json"}}, {"family": "Abd-Elsalam", "given": "Sherief", "initials": "S", "orcid": "0000-0003-4366-2218", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fb051b677594bbca20b5637fc0420a9.json"}}, {"family": "Abdo", "given": "Ehab F", "initials": "EF", "orcid": "0000-0002-9805-3850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04cb35857c4b46829ebb73f25fad291a.json"}}, {"family": "Abella", "given": "Benjamin S", "initials": "BS", "orcid": "0000-0003-2521-0891", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7572ea9966aa4951afd5d2490960148e.json"}}, {"family": "Akram", "given": "Javed", "initials": "J"}, {"family": "Amaravadi", "given": "Ravi K", "initials": "RK"}, {"family": "Angus", "given": "Derek C", "initials": "DC"}, {"family": "Arabi", "given": "Yaseen M", "initials": "YM"}, {"family": "Azhar", "given": "Shehnoor", "initials": "S"}, {"family": "Baden", "given": "Lindsey R", "initials": "LR"}, {"family": "Baker", "given": "Arthur W", "initials": "AW", "orcid": "0000-0002-0914-0291", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51dd5ed5fb784143955e3c7e587b7014.json"}}, {"family": "Belkhir", "given": "Leila", "initials": "L"}, {"family": "Benfield", "given": "Thomas", "initials": "T", "orcid": "0000-0003-0698-9385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a335d1a321c46b2a0ba4f80dc3d93b4.json"}}, {"family": "Berrevoets", "given": "Marvin A H", "initials": "MAH"}, {"family": "Chen", "given": "Cheng-Pin", "initials": "CP", "orcid": "0000-0002-0629-9790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/773f850e035a47269048204713babe5f.json"}}, {"family": "Chen", "given": "Tsung-Chia", "initials": "TC", "orcid": "0000-0002-3461-5535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2df09990f13243b6a7d586e65808f9a5.json"}}, {"family": "Cheng", "given": "Shu-Hsing", "initials": "SH", "orcid": "0000-0002-6256-0527", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44efc129a6a54e9a85422a2c1122c047.json"}}, {"family": "Cheng", "given": "Chien-Yu", "initials": "CY"}, {"family": "Chung", "given": "Wei-Sheng", "initials": "WS", "orcid": "0000-0003-4240-5690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79973df7d6b94b529a779c7b3d1bc471.json"}}, {"family": "Cohen", "given": "Yehuda Z", "initials": "YZ", "orcid": "0000-0001-6987-1478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3839874cc0f4a91a69d0fb2fc15c35a.json"}}, {"family": "Cowan", "given": "Lisa N", "initials": "LN"}, {"family": "Dalgard", "given": "Olav", "initials": "O"}, {"family": "de Almeida E Val", "given": "Fernando F", "initials": "FF"}, {"family": "de Lacerda", "given": "Marcus V G", "initials": "MVG", "orcid": "0000-0003-3374-9985", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5df56fcaab5d4fbea3ee4a973b3ed44f.json"}}, {"family": "de Melo", "given": "Gisely C", "initials": "GC"}, {"family": "Derde", "given": "Lennie", "initials": "L", "orcid": "0000-0002-3577-5629", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cdd814a355e486a88cb134b060427bc.json"}}, {"family": "Dubee", "given": "Vincent", "initials": "V", "orcid": "0000-0002-9982-4741", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b4de07c4b894618b95fc8df7917ca03.json"}}, {"family": "Elfakir", "given": "Anissa", "initials": "A"}, {"family": "Gordon", "given": "Anthony C", "initials": "AC", "orcid": "0000-0002-0419-547X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/85b43173291c4fb8b83df85d5dfb3486.json"}}, {"family": "Hernandez-Cardenas", "given": "Carmen M", "initials": "CM", "orcid": "0000-0002-0311-2978", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0aa3c0ab8d3b4da0a63a8d81a5c7d798.json"}}, {"family": "Hills", "given": "Thomas", "initials": "T", "orcid": "0000-0003-0322-5822", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf854b51c68b4b3fb3edee63faa3dfff.json"}}, {"family": "Hoepelman", "given": "Andy I M", "initials": "AIM"}, {"family": "Huang", "given": "Yi-Wen", "initials": "YW"}, {"family": "Igau", "given": "Bruno", "initials": "B"}, {"family": "Jin", "given": "Ronghua", "initials": "R"}, {"family": "Jurado-Camacho", "given": "Felipe", "initials": "F"}, {"family": "Khan", "given": "Khalid S", "initials": "KS"}, {"family": "Kremsner", "given": "Peter G", "initials": "PG"}, {"family": "Kreuels", "given": "Benno", "initials": "B", "orcid": "0000-0003-2315-8954", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/752c98a06cbb43f9b5b8bf63127dd654.json"}}, {"family": "Kuo", "given": "Cheng-Yu", "initials": "CY"}, {"family": "Le", "given": "Thuy", "initials": "T", "orcid": "0000-0002-3393-6580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2380b23c0d1f423aa831d72279980706.json"}}, {"family": "Lin", "given": "Yi-Chun", "initials": "YC"}, {"family": "Lin", "given": "Wu-Pu", "initials": "WP", "orcid": "0000-0002-4206-7882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86d19e5169de4a139c6508eb7bd1e085.json"}}, {"family": "Lin", "given": "Tse-Hung", "initials": "TH"}, {"family": "Lyngbakken", "given": "Magnus Nakrem", "initials": "MN", "orcid": "0000-0002-5994-9304", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70c443e4d3674615bf090ed3b0d39e98.json"}}, {"family": "McArthur", "given": "Colin", "initials": "C"}, {"family": "McVerry", "given": "Bryan J", "initials": "BJ", "orcid": "0000-0002-1175-4874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/941d8c555b224fb18d897e9201d42f35.json"}}, {"family": "Meza-Meneses", "given": "Patricia", "initials": "P", "orcid": "0000-0002-3931-3114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be8220f4a58244838e2252f67c3ea28b.json"}}, {"family": "Monteiro", "given": "Wuelton M", "initials": "WM"}, {"family": "Morpeth", "given": "Susan C", "initials": "SC"}, {"family": "Mourad", "given": "Ahmad", "initials": "A", "orcid": "0000-0002-3149-597X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3323fc32cf4e44b2b677b838954f86aa.json"}}, {"family": "Mulligan", "given": "Mark J", "initials": "MJ"}, {"family": "Murthy", "given": "Srinivas", "initials": "S"}, {"family": "Naggie", "given": "Susanna", "initials": "S"}, {"family": "Narayanasamy", "given": "Shanti", "initials": "S", "orcid": "0000-0002-6667-2868", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53cc5ca9db8d49678370dbaad3d91ac0.json"}}, {"family": "Nichol", "given": "Alistair", "initials": "A"}, {"family": "Novack", "given": "Lewis A", "initials": "LA"}, {"family": "O'Brien", "given": "Sean M", "initials": "SM"}, {"family": "Okeke", "given": "Nwora Lance", "initials": "NL"}, {"family": "Perez", "given": "L\u00e9na", "initials": "L"}, {"family": "Perez-Padilla", "given": "Rogelio", "initials": "R"}, {"family": "Perrin", "given": "Laurent", "initials": "L", "orcid": "0000-0002-1916-6639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bdac388f14a404aa6a02e69083181fb.json"}}, {"family": "Remigio-Luna", "given": "Arantxa", "initials": "A"}, {"family": "Rivera-Martinez", "given": "Norma E", "initials": "NE", "orcid": "0000-0002-6716-1234", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0214c04c5d94f0082f9068398ab6e37.json"}}, {"family": "Rockhold", "given": "Frank W", "initials": "FW", "orcid": "0000-0003-3732-4765", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/409f57f9cdcd46f7bac6c309f50f6673.json"}}, {"family": "Rodriguez-Llamazares", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-7864-8953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76eb08936ea3405eb020251713f28c3d.json"}}, {"family": "Rolfe", "given": "Robert", "initials": "R"}, {"family": "Rosa", "given": "Rossana", "initials": "R"}, {"family": "R\u00f8sj\u00f8", "given": "Helge", "initials": "H"}, {"family": "Sampaio", "given": "Vanderson S", "initials": "VS", "orcid": "0000-0001-7307-8851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/934ee588c764416998481a7dbe4aad3e.json"}}, {"family": "Seto", "given": "Todd B", "initials": "TB"}, {"family": "Shahzad", "given": "Muhammad", "initials": "M"}, {"family": "Soliman", "given": "Shaimaa", "initials": "S"}, {"family": "Stout", "given": "Jason E", "initials": "JE", "orcid": "0000-0002-6698-8176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45ca2262503a439db34471f94f65aa11.json"}}, {"family": "Thirion-Romero", "given": "Ireri", "initials": "I"}, {"family": "Troxel", "given": "Andrea B", "initials": "AB"}, {"family": "Tseng", "given": "Ting-Yu", "initials": "TY"}, {"family": "Turner", "given": "Nicholas A", "initials": "NA", "orcid": "0000-0003-0650-4894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7aa17d22034b4cc4aca4c38f6323c099.json"}}, {"family": "Ulrich", "given": "Robert J", "initials": "RJ", "orcid": "0000-0002-3217-5062", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d560647d4cd74ecaa958445933fef02d.json"}}, {"family": "Walsh", "given": "Stephen R", "initials": "SR", "orcid": "0000-0002-0817-9370", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5569d26075364c7294b1d49d084d27bf.json"}}, {"family": "Webb", "given": "Steve A", "initials": "SA"}, {"family": "Weehuizen", "given": "Jesper M", "initials": "JM"}, {"family": "Velinova", "given": "Maria", "initials": "M"}, {"family": "Wong", "given": "Hon-Lai", "initials": "HL"}, {"family": "Wrenn", "given": "Rebekah", "initials": "R"}, {"family": "Zampieri", "given": "Fernando G", "initials": "FG", "orcid": "0000-0001-9315-6386", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6d3264c064a4675bdbde7937711265c.json"}}, {"family": "Zhong", "given": "Wu", "initials": "W", "orcid": "0000-0002-0536-620X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8058cd239379403195b1cd7d9b5ca689.json"}}, {"family": "Moher", "given": "David", "initials": "D", "orcid": "0000-0003-2434-4206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/765e99136e2943c7a7f4ce4ed5848ff9.json"}}, {"family": "Goodman", "given": "Steven N", "initials": "SN"}, {"family": "Ioannidis", "given": "John P A", "initials": "JPA", "orcid": "0000-0003-3118-6859", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9844ea41bc554157a721820d7986a442.json"}}, {"family": "Hemkens", "given": "Lars G", "initials": "LG", "orcid": "0000-0002-3444-1432", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b2562d656a74e7d91427b55ca667784.json"}}], "type": "journal article", "published": "2021-04-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "2349"}, "abstract": "Substantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or early discontinuation. We aim to estimate the effects of hydroxychloroquine and chloroquine on survival in COVID-19 from all currently available RCT evidence, published and unpublished. We present a rapid meta-analysis of ongoing, completed, or discontinued RCTs on hydroxychloroquine or chloroquine treatment for any COVID-19 patients (protocol: https://osf.io/QESV4/ ). We systematically identified unpublished RCTs (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, Cochrane COVID-registry up to June 11, 2020), and published RCTs (PubMed, medRxiv and bioRxiv up to October 16, 2020). All-cause mortality has been extracted (publications/preprints) or requested from investigators and combined in random-effects meta-analyses, calculating odds ratios (ORs) with 95% confidence intervals (CIs), separately for hydroxychloroquine and chloroquine. Prespecified subgroup analyses include patient setting, diagnostic confirmation, control type, and publication status. Sixty-three trials were potentially eligible. We included 14 unpublished trials (1308 patients) and 14 publications/preprints (9011 patients). Results for hydroxychloroquine are dominated by RECOVERY and WHO SOLIDARITY, two highly pragmatic trials, which employed relatively high doses and included 4716 and 1853 patients, respectively (67% of the total sample size). The combined OR on all-cause mortality for hydroxychloroquine is 1.11 (95% CI: 1.02, 1.20; I\u00b2 = 0%; 26 trials; 10,012 patients) and for chloroquine 1.77 (95%CI: 0.15, 21.13, I\u00b2 = 0%; 4 trials; 307 patients). We identified no subgroup effects. We found that treatment with hydroxychloroquine is associated with increased mortality in COVID-19 patients, and there is no benefit of chloroquine. Findings have unclear generalizability to outpatients, children, pregnant women, and people with comorbidities.", "doi": "10.1038/s41467-021-22446-z", "pmid": "33859192", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC8050319"}, {"db": "pii", "key": "10.1038/s41467-021-22446-z"}], "notes": [], "created": "2021-04-19T09:55:46.003Z", "modified": "2023-06-19T15:39:29.947Z"}, {"entity": "publication", "iuid": "6962a2e2313a498f92cb46da8b7054c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6962a2e2313a498f92cb46da8b7054c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6962a2e2313a498f92cb46da8b7054c9"}}, "title": "Impaired diffusing capacity for carbon monoxide is common in critically ill Covid-19 patients at four months post-discharge.", "authors": [{"family": "Ekbom", "given": "E", "initials": "E"}, {"family": "Frithiof", "given": "R", "initials": "R"}, {"family": "Emilsson", "given": "\u00d6", "initials": "\u00d6"}, {"family": "Larson", "given": "IM", "initials": "I"}, {"family": "Lipcsey", "given": "M", "initials": "M"}, {"family": "Rubertsson", "given": "S", "initials": "S"}, {"family": "Wallin", "given": "E", "initials": "E"}, {"family": "Janson", "given": "C", "initials": "C"}, {"family": "Hultstr\u00f6m", "given": ", M", "initials": ",M"}, {"family": "Malinovschi", "given": ", A", "initials": ",A"}], "type": "journal article", "published": "2021-04-15", "journal": {"title": "Respir Med", "issn": "1532-3064", "issn-l": "0954-6111", "volume": "182", "issue": null, "pages": "106394"}, "abstract": "There is limited knowledge about the long-term effects on pulmonary function of COVID-19 in patients that required intensive care treatment. Spirometry and diffusing capacity for carbon monoxide (DLCO) were measured in 60 subjects at 3-6 months post discharge. Impaired lung function was found in 52% of the subjects, with reduced DLCO as the main finding. The risk increased with age above 60 years, need for mechanical ventilation and longer ICU stay as well as lower levels of C-reactive protein at admission. This suggests the need of follow-up with pulmonary function testing in intensive-care treated patients.", "doi": "10.1016/j.rmed.2021.106394", "pmid": "33901787", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pii", "key": "S0954-6111(21)00100-1"}], "notes": [], "created": "2021-04-29T10:24:46.257Z", "modified": "2021-06-11T14:13:00.138Z"}, {"entity": "publication", "iuid": "a78e8cfff07a42a39fd12fc31fd02007", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a78e8cfff07a42a39fd12fc31fd02007.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a78e8cfff07a42a39fd12fc31fd02007"}}, "title": "Impacts of COVID-19 on sick leave", "authors": [{"family": "Skyrud", "given": "Katrine", "initials": "K"}, {"family": "Telle", "given": "Kjetil", "initials": "K"}, {"family": "Hern\u00e6s", "given": "Kjersti", "initials": "K"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "posted-content", "published": "2021-04-15", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.09.21255215", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-14T06:41:17.696Z", "modified": "2021-06-18T09:28:15.257Z"}, {"entity": "publication", "iuid": "2813f0500ac641f09c8b641b69e12be7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2813f0500ac641f09c8b641b69e12be7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2813f0500ac641f09c8b641b69e12be7"}}, "title": "Immune Profile in Patients With COVID-19: Lymphocytes Exhaustion Markers in Relationship to Clinical Outcome.", "authors": [{"family": "Bobcakova", "given": "Anna", "initials": "A"}, {"family": "Petriskova", "given": "Jela", "initials": "J"}, {"family": "Vysehradsky", "given": "Robert", "initials": "R"}, {"family": "Kocan", "given": "Ivan", "initials": "I"}, {"family": "Kapustova", "given": "Lenka", "initials": "L"}, {"family": "Barnova", "given": "Martina", "initials": "M"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}, {"family": "Jesenak", "given": "Milos", "initials": "M"}], "type": "journal article", "published": "2021-04-15", "journal": {"title": "Front Cell Infect Microbiol", "issn": "2235-2988", "volume": "11", "issue": null, "pages": "646688", "issn-l": null}, "abstract": "The velocity of the COVID-19 pandemic spread and the variable severity of the disease course has forced scientists to search for potential predictors of the disease outcome. We examined various immune parameters including the markers of immune cells exhaustion and activation in 21 patients with COVID-19 disease hospitalised in our hospital during the first wave of the COVID-19 pandemic in Slovakia. The results showed significant progressive lymphopenia and depletion of lymphocyte subsets (CD3 +, CD4+, CD8+ and CD19+) in correlation to the disease severity. Clinical recovery was associated with significant increase in CD3+ and CD3+CD4+ T-cells. Most of our patients had eosinopenia on admission, although no significant differences were seen among groups with different disease severity. Non-survivors, when compared to survivors, had significantly increased expression of PD-1 on CD4+ and CD8+ cells, but no significant difference in Tim-3 expression was observed, what suggests possible reversibility of immune paralysis in the most severe group of patients. During recovery, the expression of Tim-3 on both CD3+CD4+ and CD3+CD8+ cells significantly decreased. Moreover, patients with fatal outcome had significantly higher proportion of CD38+CD8+ cells and lower proportion of CD38+HLA-DR+CD8+ cells on admission. Clinical recovery was associated with significant decrease of proportion of CD38+CD8+ cells. The highest AUC values within univariate and multivariate logistic regression were achieved for expression of CD38 on CD8+ cells and expression of PD1 on CD4+ cells alone or combined, what suggests, that these parameters could be used as potential biomarkers of poor outcome. The assessment of immune markers could help in predicting outcome and disease severity in COVID-19 patients. Our observations suggest, that apart from the degree of depletion of total lymphocytes and lymphocytes subsets, increased expression of CD38 on CD3+CD8+ cells alone or combined with increased expression of PD-1 on CD3+CD4+ cells, should be regarded as a risk factor of an unfavourable outcome in COVID-19 patients. Increased expression of PD-1 in the absence of an increased expression of Tim-3 on CD3+CD4+ and CD3+CD8+ cells suggests potential reversibility of ongoing immune paralysis in patients with the most severe course of COVID-19.", "doi": "10.3389/fcimb.2021.646688", "pmid": "33937096", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8082075"}], "notes": [], "created": "2021-05-04T15:59:00.820Z", "modified": "2021-05-04T15:59:29.077Z"}, {"entity": "publication", "iuid": "59f5bb4de6904a3c86e0194414dec772", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/59f5bb4de6904a3c86e0194414dec772.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/59f5bb4de6904a3c86e0194414dec772"}}, "title": "Appropriateness for SARS-CoV-2 vaccination for otolaryngologist and head and neck surgeons in case of pregnancy, breastfeeding, or childbearing potential: Yo-IFOS and CEORL-HNS joint clinical consensus statement.", "authors": [{"family": "Saibene", "given": "Alberto Maria", "initials": "AM"}, {"family": "Allevi", "given": "Fabiana", "initials": "F"}, {"family": "Ayad", "given": "Tareck", "initials": "T"}, {"family": "Baudoin", "given": "Tomislav", "initials": "T"}, {"family": "Bernal-Sprekelsen", "given": "Manuel", "initials": "M"}, {"family": "Briganti", "given": "Giovanni", "initials": "G"}, {"family": "Carrie", "given": "Sean", "initials": "S"}, {"family": "Cay\u00e9-Thomasen", "given": "Per", "initials": "P"}, {"family": "Dahman Saidi", "given": "Sara", "initials": "S"}, {"family": "Dauby", "given": "Nicolas", "initials": "N"}, {"family": "Fenton", "given": "John", "initials": "J"}, {"family": "Golusi\u0144ski", "given": "Wojciech", "initials": "W"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Leclerc", "given": "Andr\u00e9e-Anne", "initials": "A"}, {"family": "Longtin", "given": "Yves", "initials": "Y"}, {"family": "Mannelli", "given": "Giuditta", "initials": "G"}, {"family": "Mayo-Y\u00e1\u00f1ez", "given": "Miguel", "initials": "M"}, {"family": "Me\u00e7o", "given": "Cem", "initials": "C"}, {"family": "Metwaly", "given": "Osama", "initials": "O"}, {"family": "Mouawad", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Niemczyk", "given": "Kazimierz", "initials": "K"}, {"family": "Pedersen", "given": "Ulrik", "initials": "U"}, {"family": "Piersiala", "given": "Krzysztof", "initials": "K"}, {"family": "Plzak", "given": "Jan", "initials": "J"}, {"family": "Remacle", "given": "Marc", "initials": "M"}, {"family": "Rommel", "given": "Nathalie", "initials": "N"}, {"family": "Saleh", "given": "Hesham", "initials": "H"}, {"family": "Szpecht", "given": "Dawid", "initials": "D"}, {"family": "Tedla", "given": "Miroslav", "initials": "M"}, {"family": "Tincati", "given": "Camilla", "initials": "C"}, {"family": "Tucciarone", "given": "Manuel", "initials": "M"}, {"family": "Zelenik", "given": "Karol", "initials": "K"}, {"family": "Lechien", "given": "Jerome R", "initials": "JR"}], "type": "journal article", "published": "2021-04-15", "journal": {"title": "Eur Arch Otorhinolaryngol", "issn": "1434-4726", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "SARS-CoV-2 vaccines are a key step in fighting the pandemic. Nevertheless, their rapid development did not allow for testing among specific population subgroups such as pregnant and breastfeeding women, or elaborating specific guidelines for healthcare personnel working in high infection risk specialties, such as otolaryngology (ORL). This clinical consensus statement (CCS) aims to offer guidance for SARS-CoV-2 vaccination to this high-risk population based on the best evidence available.\r\n\r\nA multidisciplinary international panel of 33 specialists judged statements through a two-round modified Delphi method survey. Statements were designed to encompass the following topics: risk of SARS-Cov-2 infection and use of protective equipment in ORL; SARS-Cov-2 infection and vaccines and respective risks for the mother/child dyad; and counseling for SARS-CoV-2 vaccination in pregnant, breastfeeding, or fertile healthcare workers (PBFHW). All ORL PBFHW were considered as the target audience.\r\n\r\nOf the 13 statements, 7 reached consensus or strong consensus, 2 reached no consensus, and 2 reached near-consensus. According to the statements with strong consensus otorhinolaryngologists-head and neck surgeons who are pregnant, breastfeeding, or with childbearing potential should have the opportunity to receive SARS-Cov-2 vaccination. Moreover, personal protective equipment (PPE) should still be used even after the vaccination.\r\n\r\nUntil prospective evaluations on these topics are available, ORL-HNS must be considered a high infection risk specialty. While the use of PPE remains pivotal, ORL PBFHW should be allowed access to SARS-CoV-2 vaccination provided they receive up-to-date information.", "doi": "10.1007/s00405-021-06794-6", "pmid": "33855628", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00405-021-06794-6"}, {"db": "pmc", "key": "PMC8046580"}], "notes": [], "created": "2021-04-19T09:53:24.711Z", "modified": "2021-04-19T09:53:40.064Z"}, {"entity": "publication", "iuid": "ad1e20fc179f437b8ca521f323d4b8ea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ad1e20fc179f437b8ca521f323d4b8ea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ad1e20fc179f437b8ca521f323d4b8ea"}}, "title": "A distinct metabolic profile associated with a fatal outcome in COVID-19 patients during early epidemic in Italy", "authors": [{"family": "Saccon", "given": "Elisa", "initials": "E"}, {"family": "Bandera", "given": "Alessandra", "initials": "A"}, {"family": "Scium\u00e8", "given": "Mariarita", "initials": "M"}, {"family": "Mikeloff", "given": "Flora", "initials": "F"}, {"family": "Lashari", "given": "Abid Ali", "initials": "AA"}, {"family": "Aliberti", "given": "Stefano", "initials": "S"}, {"family": "Sachs", "given": "Michael", "initials": "M"}, {"family": "Billi", "given": "Filippo", "initials": "F"}, {"family": "Blasi", "given": "Francesco", "initials": "F"}, {"family": "Gabriel", "given": "Erin", "initials": "E"}, {"family": "Costantino", "given": "Giorgio", "initials": "G"}, {"family": "De Roberto", "given": "Pasquale", "initials": "P"}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Gori", "given": "Andrea", "initials": "A"}, {"family": "Peyvandi", "given": "Flora", "initials": "F"}, {"family": "Scudeller", "given": "Luigia", "initials": "L"}, {"family": "Lorson", "given": "Christian L", "initials": "CL"}, {"family": "Valenti", "given": "Luca", "initials": "L"}, {"family": "Singh", "given": "Kamal", "initials": "K"}, {"family": "Baldini", "given": "Luca", "initials": "L"}, {"family": "Fracchiolla", "given": "Nicola Stefano", "initials": "NS"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "posted-content", "published": "2021-04-15", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.13.21255117", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-29T16:43:34.352Z", "modified": "2021-06-04T14:21:33.699Z"}, {"entity": "publication", "iuid": "3f9371406eef47b4b4cb3d96d22bf226", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f9371406eef47b4b4cb3d96d22bf226.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f9371406eef47b4b4cb3d96d22bf226"}}, "title": "Coronavirus Disease 19 from the Perspective of Ageing with Focus on Nutritional Status and Nutrition Management-A Narrative Review.", "authors": [{"family": "Rothenberg", "given": "Elisabet", "initials": "E"}], "type": "journal article", "published": "2021-04-14", "journal": {"title": "Nutrients", "issn": "2072-6643", "volume": "13", "issue": "4", "issn-l": null}, "abstract": "The novel severe acute respiratory syndrome coronavirus (COVID-19) has hit older adults harder due to a combination of age-related immunological and metabolic alterations. The aim of this review was to analyze the COVID-19 literature with respect to nutritional status and nutrition management in older adults. No studies only on people aged 65+ years were found, and documentation on those 80+ was rare. Age was found to be strongly associated with worse outcomes, and with poor nutritional status. Prevalence of malnutrition was high among severely and critically ill patients. The studies found a need for nutrition screening and management, and for nutrition support as part of follow-up after a hospital stay. Most tested screening tools showed high sensitivity in identifying nutritional risk, but none were recognized as best for screening older adults with COVID-19. For diagnosing malnutrition, the Global Leadership Initiative on Malnutrition (GLIM) criteria are recommended but were not used in the studies found. Documentation of olfactory and gustatory dysfunction in relation to nutritional status is missing in older adults. Other COVID-19-associated factors with a possible impact on nutritional status are poor appetite and gastrointestinal symptoms. Vitamin D is the nutrient that has attracted the most interest. However, evidence for supplementation of COVID-19 patients is still limited and inconclusive.", "doi": "10.3390/nu13041294", "pmid": "33919840", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "nu13041294"}, {"db": "pmc", "key": "PMC8070771"}], "notes": [], "created": "2021-05-04T16:25:12.442Z", "modified": "2021-05-04T16:25:46.758Z"}, {"entity": "publication", "iuid": "f754dc7c44e04bf2ae96d4f2bf59913c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f754dc7c44e04bf2ae96d4f2bf59913c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f754dc7c44e04bf2ae96d4f2bf59913c"}}, "title": "Visual scoring of chest CT at hospital admission predicts hospitalization time and intensive care admission in Covid-19.", "authors": [{"family": "Ahlstrand", "given": "Erik", "initials": "E"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "Cajander", "given": "Per", "initials": "P"}, {"family": "Ingberg", "given": "Edvin", "initials": "E"}, {"family": "L\u00f6f", "given": "Erika", "initials": "E"}, {"family": "Wegener", "given": "Matthias", "initials": "M"}, {"family": "Lid\u00e9n", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2021-04-13", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": null, "issue": null, "pages": "1-11"}, "abstract": "Chest CT is prognostic in Covid-19 but there is a lack of consensus on how to report the CT findings. A chest CT scoring system, \u00d6CoS, was implemented in clinical routine on 1 April 2020, in \u00d6rebro Region, Sweden. The \u00d6CoS-severity score measures the extent of lung involvement. The objective of the study was to evaluate the \u00d6CoS scores as predictors of the clinical course of Covid-19.\r\n\r\nPopulation based study including data from all hospitalized patients with Covid-19 in \u00d6rebro Region during March to July 2020. We evaluated the correlations between CT scores at the time of admission to hospital and intensive care in relation to hospital and intensive care length of stay (LoS), intensive care admission and death. C-reactive protein and lymphocyte count were included as covariates in multivariate regression analyses.\r\n\r\nIn 381 included patients, the \u00d6CoS-severity score at admission closely correlated to hospital length of stay, and intensive care admission or death. At admission to intensive care, the \u00d6CoS-severity score correlated with intensive care length of stay. The \u00d6CoS-severity score was superior to basic inflammatory biomarkers in predicting clinical outcomes.\r\n\r\nChest CT visual scoring at admission to hospital predicted the clinical course of Covid-19 pneumonia.", "doi": "10.1080/23744235.2021.1910727", "pmid": "33848219", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-14T14:27:47.477Z", "modified": "2021-04-14T14:27:58.253Z"}, {"entity": "publication", "iuid": "089b4032333d45b9ae32c98f22312369", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/089b4032333d45b9ae32c98f22312369.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/089b4032333d45b9ae32c98f22312369"}}, "title": "Suicide trends in the early months of the COVID-19 pandemic: an interrupted time-series analysis of preliminary data from 21 countries.", "authors": [{"family": "Pirkis", "given": "Jane", "initials": "J"}, {"family": "John", "given": "Ann", "initials": "A"}, {"family": "Shin", "given": "Sangsoo", "initials": "S"}, {"family": "DelPozo-Banos", "given": "Marcos", "initials": "M"}, {"family": "Arya", "given": "Vikas", "initials": "V"}, {"family": "Analuisa-Aguilar", "given": "Pablo", "initials": "P"}, {"family": "Appleby", "given": "Louis", "initials": "L"}, {"family": "Arensman", "given": "Ella", "initials": "E"}, {"family": "Bantjes", "given": "Jason", "initials": "J"}, {"family": "Baran", "given": "Anna", "initials": "A"}, {"family": "Bertolote", "given": "Jose M", "initials": "JM"}, {"family": "Borges", "given": "Guilherme", "initials": "G"}, {"family": "Bre\u010di\u0107", "given": "Petrana", "initials": "P"}, {"family": "Caine", "given": "Eric", "initials": "E"}, {"family": "Castelpietra", "given": "Giulio", "initials": "G"}, {"family": "Chang", "given": "Shu-Sen", "initials": "S"}, {"family": "Colchester", "given": "David", "initials": "D"}, {"family": "Crompton", "given": "David", "initials": "D"}, {"family": "Curkovic", "given": "Marko", "initials": "M"}, {"family": "Deisenhammer", "given": "Eberhard A", "initials": "EA"}, {"family": "Du", "given": "Chengan", "initials": "C"}, {"family": "Dwyer", "given": "Jeremy", "initials": "J"}, {"family": "Erlangsen", "given": "Annette", "initials": "A"}, {"family": "Faust", "given": "Jeremy S", "initials": "JS"}, {"family": "Fortune", "given": "Sarah", "initials": "S"}, {"family": "Garrett", "given": "Andrew", "initials": "A"}, {"family": "George", "given": "Devin", "initials": "D"}, {"family": "Gerstner", "given": "Rebekka", "initials": "R"}, {"family": "Gilissen", "given": "Renske", "initials": "R"}, {"family": "Gould", "given": "Madelyn", "initials": "M"}, {"family": "Hawton", "given": "Keith", "initials": "K"}, {"family": "Kanter", "given": "Joseph", "initials": "J"}, {"family": "Kapur", "given": "Navneet", "initials": "N"}, {"family": "Khan", "given": "Murad", "initials": "M"}, {"family": "Kirtley", "given": "Olivia J", "initials": "OJ"}, {"family": "Knipe", "given": "Duleeka", "initials": "D"}, {"family": "Kolves", "given": "Kairi", "initials": "K"}, {"family": "Leske", "given": "Stuart", "initials": "S"}, {"family": "Marahatta", "given": "Kedar", "initials": "K"}, {"family": "Mittendorfer-Rutz", "given": "Ellenor", "initials": "E"}, {"family": "Neznanov", "given": "Nikolay", "initials": "N"}, {"family": "Niederkrotenthaler", "given": "Thomas", "initials": "T"}, {"family": "Nielsen", "given": "Emma", "initials": "E"}, {"family": "Nordentoft", "given": "Merete", "initials": "M"}, {"family": "Oberlerchner", "given": "Herwig", "initials": "H"}, {"family": "O'Connor", "given": "Rory C", "initials": "RC"}, {"family": "Pearson", "given": "Melissa", "initials": "M"}, {"family": "Phillips", "given": "Michael R", "initials": "MR"}, {"family": "Platt", "given": "Steve", "initials": "S"}, {"family": "Plener", "given": "Paul L", "initials": "PL"}, {"family": "Psota", "given": "Georg", "initials": "G"}, {"family": "Qin", "given": "Ping", "initials": "P"}, {"family": "Radeloff", "given": "Daniel", "initials": "D"}, {"family": "Rados", "given": "Christa", "initials": "C"}, {"family": "Reif", "given": "Andreas", "initials": "A"}, {"family": "Reif-Leonhard", "given": "Christine", "initials": "C"}, {"family": "Rozanov", "given": "Vsevolod", "initials": "V"}, {"family": "Schlang", "given": "Christiane", "initials": "C"}, {"family": "Schneider", "given": "Barbara", "initials": "B"}, {"family": "Semenova", "given": "Natalia", "initials": "N"}, {"family": "Sinyor", "given": "Mark", "initials": "M"}, {"family": "Townsend", "given": "Ellen", "initials": "E"}, {"family": "Ueda", "given": "Michiko", "initials": "M"}, {"family": "Vijayakumar", "given": "Lakshmi", "initials": "L"}, {"family": "Webb", "given": "Roger T", "initials": "RT"}, {"family": "Weerasinghe", "given": "Manjula", "initials": "M"}, {"family": "Zalsman", "given": "Gil", "initials": "G"}, {"family": "Gunnell", "given": "David", "initials": "D"}, {"family": "Spittal", "given": "Matthew J", "initials": "MJ"}], "type": "journal article", "published": "2021-04-13", "journal": {"title": "Lancet Psychiatry", "issn": "2215-0374", "issn-l": "2215-0366", "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic is having profound mental health consequences for many people. Concerns have been expressed that, at their most extreme, these consequences could manifest as increased suicide rates. We aimed to assess the early effect of the COVID-19 pandemic on suicide rates around the world.\r\n\r\nWe sourced real-time suicide data from countries or areas within countries through a systematic internet search and recourse to our networks and the published literature. Between Sept 1 and Nov 1, 2020, we searched the official websites of these countries' ministries of health, police agencies, and government-run statistics agencies or equivalents, using the translated search terms \"suicide\" and \"cause of death\", before broadening the search in an attempt to identify data through other public sources. Data were included from a given country or area if they came from an official government source and were available at a monthly level from at least Jan 1, 2019, to July 31, 2020. Our internet searches were restricted to countries with more than 3 million residents for pragmatic reasons, but we relaxed this rule for countries identified through the literature and our networks. Areas within countries could also be included with populations of less than 3 million. We used an interrupted time-series analysis to model the trend in monthly suicides before COVID-19 (from at least Jan 1, 2019, to March 31, 2020) in each country or area within a country, comparing the expected number of suicides derived from the model with the observed number of suicides in the early months of the pandemic (from April 1 to July 31, 2020, in the primary analysis).\r\n\r\nWe sourced data from 21 countries (16 high-income and five upper-middle-income countries), including whole-country data in ten countries and data for various areas in 11 countries). Rate ratios (RRs) and 95% CIs based on the observed versus expected numbers of suicides showed no evidence of a significant increase in risk of suicide since the pandemic began in any country or area. There was statistical evidence of a decrease in suicide compared with the expected number in 12 countries or areas: New South Wales, Australia (RR 0\u00b781 [95% CI 0\u00b772-0\u00b791]); Alberta, Canada (0\u00b780 [0\u00b768-0\u00b793]); British Columbia, Canada (0\u00b776 [0\u00b766-0\u00b787]); Chile (0\u00b785 [0\u00b778-0\u00b794]); Leipzig, Germany (0\u00b749 [0\u00b732-0\u00b774]); Japan (0\u00b794 [0\u00b791-0\u00b796]); New Zealand (0\u00b779 [0\u00b768-0\u00b791]); South Korea (0\u00b794 [0\u00b792-0\u00b797]); California, USA (0\u00b790 [0\u00b785-0\u00b795]); Illinois (Cook County), USA (0\u00b779 [0\u00b767-0\u00b793]); Texas (four counties), USA (0\u00b782 [0\u00b768-0\u00b798]); and Ecuador (0\u00b774 [0\u00b767-0\u00b782]).\r\n\r\nThis is the first study to examine suicides occurring in the context of the COVID-19 pandemic in multiple countries. In high-income and upper-middle-income countries, suicide numbers have remained largely unchanged or declined in the early months of the pandemic compared with the expected levels based on the pre-pandemic period. We need to remain vigilant and be poised to respond if the situation changes as the longer-term mental health and economic effects of the pandemic unfold.\r\n\r\nNone.", "doi": "10.1016/S2215-0366(21)00091-2", "pmid": "33862016", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2215-0366(21)00091-2"}], "notes": [], "created": "2021-04-19T10:38:03.711Z", "modified": "2021-04-19T10:38:33.043Z"}, {"entity": "publication", "iuid": "84cac197afb5412a821b404f0f43a2ce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84cac197afb5412a821b404f0f43a2ce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84cac197afb5412a821b404f0f43a2ce"}}, "title": "Structure, Dynamics, Receptor Binding, and Antibody Binding of the Fully Glycosylated Full-Length SARS-CoV-2 Spike Protein in a Viral Membrane.", "authors": [{"family": "Choi", "given": "Yeol Kyo", "initials": "YK", "orcid": "0000-0002-4218-7139", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2885ea927174b0aabe0ab76d5fba484.json"}}, {"family": "Cao", "given": "Yiwei", "initials": "Y", "orcid": "0000-0002-4516-8689", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15efd17a7c1342a3aa46bab1e2b9e241.json"}}, {"family": "Frank", "given": "Martin", "initials": "M", "orcid": "0000-0002-1006-6746", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee6b5d165615455da3cf49fad65598e9.json"}}, {"family": "Woo", "given": "Hyeonuk", "initials": "H", "orcid": "0000-0002-6495-4087", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2dfd6c1c6f34de2b6b768ce70a67ebb.json"}}, {"family": "Park", "given": "Sang-Jun", "initials": "SJ", "orcid": "0000-0002-7307-3724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dede807702c34573bfe7de0b40c48de9.json"}}, {"family": "Yeom", "given": "Min Sun", "initials": "MS", "orcid": "0000-0001-9977-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7ae6fb73cfb47199fd5e4a468aa5554.json"}}, {"family": "Croll", "given": "Tristan I", "initials": "TI", "orcid": "0000-0002-3514-8377", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a6c1536819d496490962f5f89bebc6f.json"}}, {"family": "Seok", "given": "Chaok", "initials": "C", "orcid": "0000-0002-1419-9888", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a93933221aa54cda9547eb7f063c154c.json"}}, {"family": "Im", "given": "Wonpil", "initials": "W", "orcid": "0000-0001-5642-6041", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c6b1fc87fa647459c5a112e9fa6b8ce.json"}}], "type": "journal article", "published": "2021-04-13", "journal": {"title": "J Chem Theory Comput", "issn": "1549-9626", "issn-l": null, "volume": "17", "issue": "4", "pages": "2479-2487"}, "abstract": "The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mediates host cell entry by binding to angiotensin-converting enzyme 2 (ACE2) and is considered the major target for drug and vaccine development. We previously built fully glycosylated full-length SARS-CoV-2 S protein models in a viral membrane including both open and closed conformations of the receptor-binding domain (RBD) and different templates for the stalk region. In this work, multiple \u03bcs-long all-atom molecular dynamics simulations were performed to provide deeper insights into the structure and dynamics of S protein and glycan functions. Our simulations reveal that the highly flexible stalk is composed of two independent joints and most probable S protein orientations are competent for ACE2 binding. We identify multiple glycans stabilizing the open and/or closed states of the RBD and demonstrate that the exposure of antibody epitopes can be captured by detailed antibody-glycan clash analysis instead of commonly used accessible surface area analysis that tends to overestimate the impact of glycan shielding and neglect possible detailed interactions between glycan and antibodies. Overall, our observations offer structural and dynamic insights into the SARS-CoV-2 S protein and potentialize for guiding the design of effective antiviral therapeutics.", "doi": "10.1021/acs.jctc.0c01144", "pmid": "33689337", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC8047829"}], "notes": [], "created": "2021-03-12T06:09:38.310Z", "modified": "2023-06-19T14:35:39.264Z"}, {"entity": "publication", "iuid": "cf393d99432444dea582e4df887afe07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cf393d99432444dea582e4df887afe07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cf393d99432444dea582e4df887afe07"}}, "title": "Motivation to Have COVID-19 Vaccination Explained Using an Extended Protection Motivation Theory among University Students in China: The Role of Information Sources.", "authors": [{"family": "Wang", "given": "Peng-Wei", "initials": "P"}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Chen", "given": "I-Hua", "initials": "I"}, {"family": "Yen", "given": "Cheng-Fang", "initials": "C"}, {"family": "Kuo", "given": "Yi-Jie", "initials": "Y"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-04-13", "journal": {"title": "Vaccines", "issn": "2076-393X", "issn-l": null, "volume": "9", "issue": "4", "pages": null}, "abstract": "The aims of the present study were to examine the prediction of the threat and coping appraisal utilizing an extended protection motivation theory (PMT) for the motivation to have COVID-19 vaccination and the influence of various information sources on coping appraisal among university students in China.\r\n\r\nThe sample comprised 3145 students from 43 universities in China who completed an online survey including PMT constructs as well as constructs added to PMT. The PMT constructs comprised motivation to have COVID-19 vaccination, threat appraisal, and coping appraisal. The extended PMT constructs comprised knowledge about mechanisms and information sources of COVID-19 vaccination.\r\n\r\nPerceived severity of COVID-19 was positively associated with motivation to have COVID-19 vaccination. Receiving information concerning COVID-19 vaccination from medical personnel was associated with greater self-efficacy, response efficacy, and knowledge, whereas receiving information concerning COVID-19 vaccination from coworkers/colleagues was associated with less response efficacy and knowledge. Receiving online information concerning COVID-19 vaccination was associated with greater response cost of vaccination efficacy and less knowledge.\r\n\r\nThis study supported the prediction of perceived severity in the PMT for motivation to have COVID-19 vaccination among university students in China. Vaccination information sources have different effects on students' coping appraisal of COVID-19 vaccination.", "doi": "10.3390/vaccines9040380", "pmid": "33924604", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "vaccines9040380"}, {"db": "pmc", "key": "PMC8070343"}], "notes": [], "created": "2021-05-04T16:22:30.374Z", "modified": "2021-07-14T07:14:10.905Z"}, {"entity": "publication", "iuid": "754c69dd322a4156bbbbb6d9131ce4ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/754c69dd322a4156bbbbb6d9131ce4ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/754c69dd322a4156bbbbb6d9131ce4ff"}}, "title": "GRAd-COV2, a gorilla adenovirus based candidate vaccine against COVID-19, is safe and immunogenic in young and older adults", "authors": [{"family": "Lanini", "given": "Simone", "initials": "S"}, {"family": "Capone", "given": "Stefania", "initials": "S"}, {"family": "Antinori", "given": "Andrea", "initials": "A"}, {"family": "Milleri", "given": "Stefano", "initials": "S"}, {"family": "Nicastri", "given": "Emanuele", "initials": "E"}, {"family": "Camerini", "given": "Roberto", "initials": "R"}, {"family": "Agrati", "given": "Chiara", "initials": "C"}, {"family": "Castilletti", "given": "Concetta", "initials": "C"}, {"family": "Mori", "given": "Federica", "initials": "F"}, {"family": "Sacchi", "given": "Alessandra", "initials": "A"}, {"family": "Matusali", "given": "Giulia", "initials": "G"}, {"family": "Gagliardini", "given": "Roberta", "initials": "R"}, {"family": "Ammendola", "given": "Virginia", "initials": "V"}, {"family": "Cimini", "given": "Eleonora", "initials": "E"}, {"family": "Grazioli", "given": "Fabiana", "initials": "F"}, {"family": "Scorzolini", "given": "Laura", "initials": "L"}, {"family": "Napolitano", "given": "Federico", "initials": "F"}, {"family": "Piazzi", "given": "Maria Maddalena", "initials": "MM"}, {"family": "Soriani", "given": "Marco", "initials": "M"}, {"family": "De Luca", "given": "Aldo", "initials": "A"}, {"family": "Battella", "given": "Simone", "initials": "S"}, {"family": "Sommella", "given": "Andrea", "initials": "A"}, {"family": "Contino", "given": "Alessandra M", "initials": "AM"}, {"family": "Barra", "given": "Federica", "initials": "F"}, {"family": "Gentile", "given": "Michela", "initials": "M"}, {"family": "Raggioli", "given": "Angelo", "initials": "A"}, {"family": "Shi", "given": "Yufang", "initials": "Y"}, {"family": "Girardi", "given": "Enrico", "initials": "E"}, {"family": "Maeurer", "given": "Markus", "initials": "M"}, {"family": "Capobianchi", "given": "Maria R", "initials": "MR"}, {"family": "Vaia", "given": "Francesco", "initials": "F"}, {"family": "Piacentini", "given": "Mauro", "initials": "M"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}, {"family": "Vitelli", "given": "Alessandra", "initials": "A"}, {"family": "Colloca", "given": "Stefano", "initials": "S"}, {"family": "Folgori", "given": "Antonella", "initials": "A"}, {"family": "Ippolito", "given": "Giuseppe", "initials": "G"}], "type": "posted-content", "published": "2021-04-13", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.10.21255202", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT04528641", "description": "Cinical trials of GRAd-COV2, a vaccine candidate based on an adenoviral vector derived from a group C Gorilla adenovirus"}], "notes": [], "created": "2021-05-29T16:44:59.400Z", "modified": "2021-11-18T09:44:28.193Z"}, {"entity": "publication", "iuid": "95f9816c0e174280b914ea2b935abbc7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95f9816c0e174280b914ea2b935abbc7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95f9816c0e174280b914ea2b935abbc7"}}, "title": "Does International Travel Frequency Affect COVID-19 Biosecurity Behavior in the United States?", "authors": [{"family": "Kim", "given": "Myung Ja", "initials": "MJ"}, {"family": "Hall", "given": "C Michael", "initials": "CM"}, {"family": "Bonn", "given": "Mark", "initials": "M"}], "type": "journal article", "published": "2021-04-13", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "8", "issn-l": null}, "abstract": "High-quality biosecurity practices are critical to restarting international tourism. Effective market segmentation improves the communication and efficacy of health advice. Travel frequency is an important basis for health-related consumer segmentation, as it is closely related to risk of greater exposure to infectious diseases. Theoretically grounded studies of tourist biosecurity behavior and travel frequency have largely been neglected, although insights into practices and attitudes are especially relevant for coronavirus disease of 2019 (COVID-19 (coronavirus disease of 2019) health responses. Therefore, this research constructed and tested a conceptual model applying Value-Attitude-Behavior theory to US travelers to see whether the frequency of international travel affected tourist COVID-19 related biosecurity behavior. US respondents were drawn from a panel using a quota sampling technique according to the age and gender of American outbound tourists. An online survey was administered in September 2020. The responses (n = 395) of those who traveled internationally within five years were analyzed utilizing partial least squares-structural equation modeling (PLS-SEM) with multi-group analysis. Travel frequency significantly affects biosecurity behavior. High travel frequency (\u22658 trips) has the strongest effect of value on biosecurity attitudes, personal norms, social norms, and biosecurity social norms, leading to biosecurity behaviors. Biosecurity behaviors pertaining to medium travel frequency (4-7 trips) are significantly influenced by personal norms. At low travel frequency (1-3 trips) levels, biosecurity behaviors are stimulated by biosecurity attitudes and social norms, showing the highest predictive power among the three groups. This work provides insights into international travel consumer biosecurity practices and behavior. From a market segmentation perspective, the levels of international travel frequency have various influences on biosecurity values, attitudes, personal norms, social norms, and behaviors. The biosecurity behaviors of low-frequency travelers are found to be the most significant of the three groups, suggesting that individuals who travel less frequently are more likely to practice responsible COVID-19 biosecurity behavior.", "doi": "10.3390/ijerph18084111", "pmid": "33924641", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "ijerph18084111"}, {"db": "pmc", "key": "PMC8068867"}], "notes": [], "created": "2021-05-04T16:22:01.814Z", "modified": "2021-05-04T16:22:01.829Z"}, {"entity": "publication", "iuid": "2a61f282b9484a34bfe7e8b39ea3d2f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2a61f282b9484a34bfe7e8b39ea3d2f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2a61f282b9484a34bfe7e8b39ea3d2f4"}}, "title": "A Deferred-Vaccination Design to Assess Durability of COVID-19 Vaccine Effect After the Placebo Group Is Vaccinated.", "authors": [{"family": "Follmann", "given": "Dean", "initials": "D"}, {"family": "Fintzi", "given": "Jonathan", "initials": "J"}, {"family": "Fay", "given": "Michael P", "initials": "MP"}, {"family": "Janes", "given": "Holly E", "initials": "HE"}, {"family": "Baden", "given": "Lindsey R", "initials": "LR"}, {"family": "El Sahly", "given": "Hana M", "initials": "HM"}, {"family": "Fleming", "given": "Thomas R", "initials": "TR"}, {"family": "Mehrotra", "given": "Devan V", "initials": "DV"}, {"family": "Carpp", "given": "Lindsay N", "initials": "LN"}, {"family": "Juraska", "given": "Michal", "initials": "M"}, {"family": "Benkeser", "given": "David", "initials": "D"}, {"family": "Donnell", "given": "Deborah", "initials": "D"}, {"family": "Fong", "given": "Youyi", "initials": "Y"}, {"family": "Han", "given": "Shu", "initials": "S"}, {"family": "Hirsch", "given": "Ian", "initials": "I"}, {"family": "Huang", "given": "Ying", "initials": "Y"}, {"family": "Huang", "given": "Yunda", "initials": "Y"}, {"family": "Hyrien", "given": "Ollivier", "initials": "O"}, {"family": "Luedtke", "given": "Alex", "initials": "A"}, {"family": "Carone", "given": "Marco", "initials": "M"}, {"family": "Nason", "given": "Martha", "initials": "M"}, {"family": "Vandebosch", "given": "An", "initials": "A"}, {"family": "Zhou", "given": "Honghong", "initials": "H"}, {"family": "Cho", "given": "Iksung", "initials": "I"}, {"family": "Gabriel", "given": "Erin", "initials": "E"}, {"family": "Kublin", "given": "James G", "initials": "JG"}, {"family": "Cohen", "given": "Myron S", "initials": "MS"}, {"family": "Corey", "given": "Lawrence", "initials": "L"}, {"family": "Gilbert", "given": "Peter B", "initials": "PB"}, {"family": "Neuzil", "given": "Kathleen M", "initials": "KM"}], "type": "journal article", "published": "2021-04-13", "journal": {"title": "Ann Intern Med", "issn": "1539-3704", "volume": null, "issue": null, "issn-l": "0003-4819"}, "abstract": "Multiple candidate vaccines to prevent COVID-19 have entered large-scale phase 3 placebo-controlled randomized clinical trials, and several have demonstrated substantial short-term efficacy. At some point after demonstration of substantial efficacy, placebo recipients should be offered the efficacious vaccine from their trial, which will occur before longer-term efficacy and safety are known. The absence of a placebo group could compromise assessment of longer-term vaccine effects. However, by continuing follow-up after vaccination of the placebo group, this study shows that placebo-controlled vaccine efficacy can be mathematically derived by assuming that the benefit of vaccination over time has the same profile for the original vaccine recipients and the original placebo recipients after their vaccination. Although this derivation provides less precise estimates than would be obtained by a standard trial where the placebo group remains unvaccinated, this proposed approach allows estimation of longer-term effect, including durability of vaccine efficacy and whether the vaccine eventually becomes harmful for some. Deferred vaccination, if done open-label, may lead to riskier behavior in the unblinded original vaccine group, confounding estimates of long-term vaccine efficacy. Hence, deferred vaccination via blinded crossover, where the vaccine group receives placebo and vice versa, would be the preferred way to assess vaccine durability and potential delayed harm. Deferred vaccination allows placebo recipients timely access to the vaccine when it would no longer be proper to maintain them on placebo, yet still allows important insights about immunologic and clinical effectiveness over time.", "doi": "10.7326/M20-8149", "pmid": "33844575", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-04-13T10:23:58.229Z", "modified": "2021-06-09T19:27:27.661Z"}, {"entity": "publication", "iuid": "734e379716ef4c33beee223fbf443d36", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/734e379716ef4c33beee223fbf443d36.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/734e379716ef4c33beee223fbf443d36"}}, "title": "UNRAVELING THE THREAD OF UNCONTROLLED IMMUNE RESPONSE IN COVID-19 AND STEMI: AN EMERGING NEED FOR KNOWLEDGE SHARING.", "authors": [{"family": "Rios-Navarro", "given": "Cesar", "initials": "C"}, {"family": "de Dios", "given": "Elena", "initials": "E"}, {"family": "Forteza", "given": "Maria J", "initials": "MJ"}, {"family": "Bodi", "given": "Vicente", "initials": "V"}], "type": "journal article", "published": "2021-04-12", "journal": {"title": "Am J Physiol Heart Circ Physiol", "issn": "1522-1539", "volume": null, "issue": null, "issn-l": null}, "abstract": "The outbreak of severe acute respiratory syndrome coronavirus 2 that first emerged in Wuhan in December 2019 has resulted in the devastating pandemic of coronavirus disease 2019, creating an emerging need for knowledge sharing. Meanwhile, myocardial infarction is and will probably remain the foremost cause of death in the western world throughout the coming decades. Severe deregulation of the immune system can unnecessarily expand the inflammatory response and participate in target and multiple organ failure, in infection but also in critical illness. Indeed, the course and fate of inflammatory cells observed in severe ST-elevation myocardial infarction (neutrophilia, monocytosis and lymphopenia) almost perfectly mirror those recently reported in severe coronavirus disease 2019. A pleiotropic proinflammatory imbalance hampers adaptive immunity in favor of uncontrolled innate immunity and is associated with poorer structural and clinical outcomes. The goal of the present review is to gain greater insight into the cellular and molecular mechanisms underlying this canonical activation and downregulation of the two arms of the immune response in both entities, to better understand their pathophysiology as well as to open the door to innovative therapeutic options. Knowledge sharing can pave the way for therapies with the potential to significantly reduce mortality in both infectious and non-infectious scenarios.", "doi": "10.1152/ajpheart.00934.2020", "pmid": "33844596", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-04-13T10:24:51.869Z", "modified": "2021-04-13T10:25:49.802Z"}, {"entity": "publication", "iuid": "89838a83ae4e439b8431bd07607f3dd6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/89838a83ae4e439b8431bd07607f3dd6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/89838a83ae4e439b8431bd07607f3dd6"}}, "title": "Psychological distress among health professional students during the COVID-19 outbreak - Corrigendum.", "authors": [{"family": "Li", "given": "Yuchen", "initials": "Y"}, {"family": "Wang", "given": "Yue", "initials": "Y"}, {"family": "Jiang", "given": "Jingwen", "initials": "J"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Fall", "given": "Katja", "initials": "K"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Song", "given": "Huan", "initials": "H"}, {"family": "Lu", "given": "Donghao", "initials": "D"}, {"family": "Zhang", "given": "Wei", "initials": "W"}], "type": "journal article", "published": "2021-04-12", "journal": {"title": "Psychol Med", "issn": "1469-8978", "issn-l": "0033-2917", "volume": null, "issue": null, "pages": "1"}, "abstract": null, "doi": "10.1017/S0033291721000714", "pmid": "33843513", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0033291721000714"}], "notes": [], "created": "2021-04-13T10:20:05.981Z", "modified": "2021-07-14T06:59:46.032Z"}, {"entity": "publication", "iuid": "f5e0b6f1a3454be68c578886559abd14", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f5e0b6f1a3454be68c578886559abd14.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f5e0b6f1a3454be68c578886559abd14"}}, "title": "How much is good enough? Insights from myocardial infarction incidence during COVID-19 pandemic.", "authors": [{"family": "Fedorowski", "given": "Artur", "initials": "A"}, {"family": "Erlinge", "given": "David", "initials": "D"}], "type": "editorial", "published": "2021-04-12", "journal": {"title": "Int J Cardiol", "issn": "1874-1754", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/j.ijcard.2021.04.020", "pmid": "33857541", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0167-5273(21)00656-2"}], "notes": [], "created": "2021-04-19T09:54:49.854Z", "modified": "2021-04-29T16:33:48.001Z"}, {"entity": "publication", "iuid": "e3290821941b4153ad8069aac785985e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3290821941b4153ad8069aac785985e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3290821941b4153ad8069aac785985e"}}, "title": "An episode of oral mucositis after the first administration of the ChAdOx1 COVID-19 vaccine.", "authors": [{"family": "Azzi", "given": "Lorenzo", "initials": "L"}, {"family": "Toia", "given": "Marco", "initials": "M"}, {"family": "Stevanello", "given": "Nicole", "initials": "N"}, {"family": "Maggi", "given": "Fabrizio", "initials": "F"}, {"family": "Forlani", "given": "Greta", "initials": "G"}], "type": "letter", "published": "2021-04-12", "journal": {"title": "Oral Dis", "issn": "1601-0825", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1111/odi.13874", "pmid": "33844386", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-13T10:22:50.951Z", "modified": "2021-04-13T10:23:14.796Z"}, {"entity": "publication", "iuid": "0a5e0740e18b4707946abdb229678dc8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a5e0740e18b4707946abdb229678dc8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a5e0740e18b4707946abdb229678dc8"}}, "title": "Management of endocrine surgical disorders during COVID-19 pandemic: expert opinion for non-surgical options.", "authors": [{"family": "Agcaoglu", "given": "Orhan", "initials": "O"}, {"family": "Sezer", "given": "Atakan", "initials": "A"}, {"family": "Makay", "given": "Ozer", "initials": "O"}, {"family": "Erdogan", "given": "Murat Faik", "initials": "MF"}, {"family": "Bayram", "given": "Fahri", "initials": "F"}, {"family": "Guldiken", "given": "Sibel", "initials": "S"}, {"family": "Raffaelli", "given": "Marco", "initials": "M"}, {"family": "Sonmez", "given": "Yusuf Alper", "initials": "YA"}, {"family": "Lee", "given": "Yong-Sang", "initials": "YS"}, {"family": "Vamvakidis", "given": "Kyriakos", "initials": "K"}, {"family": "Mihai", "given": "Radu", "initials": "R"}, {"family": "Duh", "given": "Quan-Yang", "initials": "QY"}, {"family": "Akinci", "given": "Baris", "initials": "B"}, {"family": "Alagol", "given": "Faruk", "initials": "F"}, {"family": "Almquist", "given": "Martin", "initials": "M"}, {"family": "Barczynski", "given": "Marcin", "initials": "M"}, {"family": "Bayraktaroglu", "given": "Taner", "initials": "T"}, {"family": "Berber", "given": "Eren", "initials": "E"}, {"family": "Bukey", "given": "Yusuf", "initials": "Y"}, {"family": "Cakmak", "given": "Guldeniz Karadeniz", "initials": "GK"}, {"family": "Canturk", "given": "Nuh Zafer", "initials": "NZ"}, {"family": "Canturk", "given": "Zeynep", "initials": "Z"}, {"family": "Celik", "given": "Mehmet", "initials": "M"}, {"family": "Celik", "given": "Ozlem", "initials": "O"}, {"family": "Ceyhan", "given": "Banu Ozturk", "initials": "BO"}, {"family": "Cherenko", "given": "Sergii", "initials": "S"}, {"family": "Clerici", "given": "Thomas", "initials": "T"}, {"family": "Coombes", "given": "David Scott", "initials": "DS"}, {"family": "Demircan", "given": "Orhan", "initials": "O"}, {"family": "Deyneli", "given": "Oguzhan", "initials": "O"}, {"family": "Dionigi", "given": "Gianlorenzo", "initials": "G"}, {"family": "Emre", "given": "Ali Ugur", "initials": "AU"}, {"family": "Erbil", "given": "Yesim", "initials": "Y"}, {"family": "Filiz", "given": "Ali Ilker", "initials": "AI"}, {"family": "Gozu", "given": "Hulya Il\u0131ksu", "initials": "HI"}, {"family": "Gurdal", "given": "Sibel Ozkan", "initials": "SO"}, {"family": "Gurleyik", "given": "Gunay", "initials": "G"}, {"family": "Haciyanli", "given": "Mehmet", "initials": "M"}, {"family": "Kebudi", "given": "Abut", "initials": "A"}, {"family": "Kim", "given": "Seokmo", "initials": "S"}, {"family": "Koutelidakis", "given": "Giannis", "initials": "G"}, {"family": "Kuru", "given": "Bekir", "initials": "B"}, {"family": "Mert", "given": "Meral", "initials": "M"}, {"family": "Oruk", "given": "Guzide Gonca", "initials": "GG"}, {"family": "Ozbas", "given": "Serdar", "initials": "S"}, {"family": "Palazzo", "given": "Fausto", "initials": "F"}, {"family": "Pandev", "given": "Rumen", "initials": "R"}, {"family": "Riss", "given": "Phillip", "initials": "P"}, {"family": "Sabuncu", "given": "Tevfik", "initials": "T"}, {"family": "Sahin", "given": "Ibrahim", "initials": "I"}, {"family": "Sakman", "given": "Gurhan", "initials": "G"}, {"family": "Saygili", "given": "Fusun", "initials": "F"}, {"family": "Senyurek", "given": "Yasemin Giles", "initials": "YG"}, {"family": "Sleptsov", "given": "Ilya", "initials": "I"}, {"family": "Van Slycke", "given": "Sam", "initials": "S"}, {"family": "Teksoz", "given": "Serkan", "initials": "S"}, {"family": "Terzioglu", "given": "Tarik", "initials": "T"}, {"family": "Tezelman", "given": "Serdar", "initials": "S"}, {"family": "Tunca", "given": "Fatih", "initials": "F"}, {"family": "Ugurlu", "given": "Mustafa Umit", "initials": "MU"}, {"family": "Uludag", "given": "Mehmet", "initials": "M"}, {"family": "Villar-Del-Moral", "given": "Jesus", "initials": "J"}, {"family": "Vriens", "given": "Menno", "initials": "M"}, {"family": "Yazici", "given": "Dilek", "initials": "D"}], "type": "journal article", "published": "2021-04-11", "journal": {"title": "Updates Surg", "issn": "2038-3312", "volume": null, "issue": null, "issn-l": null}, "abstract": "The COVID-19 pandemic brought unprecedented conditions for overall health care systems by restricting resources for non-COVID-19 patients. As the burden of the disease escalates, routine elective surgeries are being cancelled. The aim of this paper was to provide a guideline for management of endocrine surgical disorders during a pandemic.\n\nWe used Delphi method with a nine-scale Likert scale on two rounds of voting involving 64 experienced eminent surgeons and endocrinologists who had the necessary experience to provide insight on endocrine disorder management. All voting was done by email using a standard questionnaire.\n\nOverall, 37 recommendations were voted on. In two rounds, all recommendations reached an agreement and were either endorsed or rejected. Endorsed statements include dietary change in primary hyperparathyroidism, Cinacalcet treatment in secondary hyperparathyroidism, alpha-blocker administration for pheochromocytoma, methimazole \u00b1 \u03b2-blocker combination for Graves' disease, and follow-up for fine-needle aspiration results of thyroid nodules indicated as Bethesda 3-4 cytological results and papillary microcarcinoma.\n\nThis survey summarizes expert opinion for the management of endocrine surgical conditions during unprecedented times when access to surgical treatment is severely disrupted. The statements are not applicable in circumstances in which surgical treatment is possible.", "doi": "10.1007/s13304-021-00979-8", "pmid": "33840069", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s13304-021-00979-8"}], "notes": [], "created": "2021-04-12T15:37:06.442Z", "modified": "2021-04-12T15:37:06.457Z"}, {"entity": "publication", "iuid": "0093b6ff3d9e4e7d9eb384ae94e166c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0093b6ff3d9e4e7d9eb384ae94e166c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0093b6ff3d9e4e7d9eb384ae94e166c5"}}, "title": "Suggestions for Shaping Tinnitus Service Provision in Western Europe: Lessons from the COVID-19 Pandemic.", "authors": [{"family": "Beukes", "given": "Eldr\u00e9 W", "initials": "EW"}, {"family": "Lourenco", "given": "Matheus P C G", "initials": "MPCG"}, {"family": "Biot", "given": "Lana", "initials": "L"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Kaldo", "given": "Viktor", "initials": "V"}, {"family": "Manchaiah", "given": "Vinaya", "initials": "V"}, {"family": "Jacquemin", "given": "Laure", "initials": "L"}], "type": "journal article", "published": "2021-04-10", "journal": {"title": "Int J Clin Pract", "issn": "1742-1241", "volume": null, "issue": null, "pages": "e14196", "issn-l": null}, "abstract": "Tinnitus severity has been exacerbated due to the COVID-19 pandemic and those with tinnitus require additional support. Such support should be informed by patient preferences and needs. The objective of this study was to gather information from individuals with tinnitus living in Europe to inform stakeholders of the (i) support they needed in relation to changes associated with the COVID-19 pandemic, and (ii) suggestions regarding tinnitus care for the future.\n\nA cross-sectional mixed methods study design was used using closed and open-ended questions via an online survey. Data was gathered from 710 adults experiencing tinnitus in Western Europe, with the majority living in The Netherlands, Belgium, and Sweden. Data were analysed using qualitative content analysis and descriptive statistics.\n\nThose with tinnitus indicated the following support needs during the pandemic (a) support for tinnitus, (b) support for hearing-related difficulties, (c) social support, and (d) pandemic-related support. Five directions for future tinnitus care were provided, namely (a) need for understanding professional support and access to multidisciplinary experts, (b) greater range of therapies and resources, (c) access to more information about tinnitus, (d) prioritizing tinnitus research, and (e) more support for hearing protection and hearing loss prevention CONCLUSIONS: The findings point to the need for accessible (remote), patient-centred, suitable and evidence-based tinnitus care. Insights from the current study can be used by various stakeholders including clinical practitioners and tinnitus support services to ensure those with tinnitus have access to the help and support required in order to reduce service provision insufficiencies.", "doi": "10.1111/ijcp.14196", "pmid": "33837639", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-12T15:38:24.625Z", "modified": "2021-04-12T15:38:24.647Z"}, {"entity": "publication", "iuid": "f0c96d0826084273911cf71b16584504", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f0c96d0826084273911cf71b16584504.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f0c96d0826084273911cf71b16584504"}}, "title": "Real-world evidence and product development: Opportunities, challenges and risk mitigation.", "authors": [{"family": "Naidoo", "given": "Poobalan", "initials": "P"}, {"family": "Bouharati", "given": "C\u00e9lia", "initials": "C"}, {"family": "Rambiritch", "given": "Virendra", "initials": "V"}, {"family": "Jose", "given": "Nadina", "initials": "N"}, {"family": "Karamchand", "given": "Sumanth", "initials": "S"}, {"family": "Chilton", "given": "Robert", "initials": "R"}, {"family": "Leisegang", "given": "Rory", "initials": "R"}], "type": "journal article", "published": "2021-04-09", "journal": {"title": "Wien Klin Wochenschr", "issn": "0043-5325", "volume": null, "issue": null, "issn-l": null}, "abstract": "Real-world evidence (RWE) is derived from real-world data (RWD) sources including electronic health records, claims data, registries (disease, product) and pragmatic clinical trials. The importance of RWE derived from RWD has been once again demonstrated during the coronavirus disease 2019 (COVID-19) pandemic, as it can improve patient care by complementing information obtained from traditional clinical trial programs. Additionally, RWE can generate insights into disease mechanisms, epidemiology, patient flows in and out of healthcare systems, and drivers and barriers to optimal clinical care in real-world settings. Identifying unmet medical needs is crucial as it often can inform which investigational new drugs enter clinical trial testing, and RWE studies from hospital settings have contributed substantial progress here. RWE can also optimize the design of clinical studies, inform benefit risk assessments and use networks of pragmatic studies to help with clinical trial feasibilities and eventual trial initiation. The challenges of RWD include data quality, reproducibility and accuracy which may affect validity. RWD and RWE must be fit for purpose and one must be cognizant of inherent biases.", "doi": "10.1007/s00508-021-01851-w", "pmid": "33837463", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00508-021-01851-w"}], "notes": [], "created": "2021-04-12T16:08:25.904Z", "modified": "2021-04-12T16:08:57.222Z"}, {"entity": "publication", "iuid": "7e93d0de8ee847b78624def331e2cbe7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e93d0de8ee847b78624def331e2cbe7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e93d0de8ee847b78624def331e2cbe7"}}, "title": "Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial.", "authors": [{"family": "Ramakrishnan", "given": "Sanjay", "initials": "S"}, {"family": "Nicolau", "given": "Dan V", "initials": "DV"}, {"family": "Langford", "given": "Beverly", "initials": "B"}, {"family": "Mahdi", "given": "Mahdi", "initials": "M"}, {"family": "Jeffers", "given": "Helen", "initials": "H"}, {"family": "Mwasuku", "given": "Christine", "initials": "C"}, {"family": "Krassowska", "given": "Karolina", "initials": "K"}, {"family": "Fox", "given": "Robin", "initials": "R"}, {"family": "Binnian", "given": "Ian", "initials": "I"}, {"family": "Glover", "given": "Victoria", "initials": "V"}, {"family": "Bright", "given": "Stephen", "initials": "S"}, {"family": "Butler", "given": "Christopher", "initials": "C"}, {"family": "Cane", "given": "Jennifer L", "initials": "JL"}, {"family": "Halner", "given": "Andreas", "initials": "A"}, {"family": "Matthews", "given": "Philippa C", "initials": "PC"}, {"family": "Donnelly", "given": "Louise E", "initials": "LE"}, {"family": "Simpson", "given": "Jodie L", "initials": "JL"}, {"family": "Baker", "given": "Jonathan R", "initials": "JR"}, {"family": "Fadai", "given": "Nabil T", "initials": "NT"}, {"family": "Peterson", "given": "Stefan", "initials": "S"}, {"family": "Bengtsson", "given": "Thomas", "initials": "T"}, {"family": "Barnes", "given": "Peter J", "initials": "PJ"}, {"family": "Russell", "given": "Richard E K", "initials": "REK"}, {"family": "Bafadhel", "given": "Mona", "initials": "M"}], "type": "journal article", "published": "2021-04-09", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "volume": null, "issue": null, "issn-l": "2213-2600"}, "abstract": "Multiple early reports of patients admitted to hospital with COVID-19 showed that patients with chronic respiratory disease were significantly under-represented in these cohorts. We hypothesised that the widespread use of inhaled glucocorticoids among these patients was responsible for this finding, and tested if inhaled glucocorticoids would be an effective treatment for early COVID-19.\n\nWe performed an open-label, parallel-group, phase 2, randomised controlled trial (Steroids in COVID-19; STOIC) of inhaled budesonide, compared with usual care, in adults within 7 days of the onset of mild COVID-19 symptoms. The trial was done in the community in Oxfordshire, UK. Participants were randomly assigned to inhaled budsonide or usual care stratified for age (\u226440 years or >40 years), sex (male or female), and number of comorbidities (\u22641 and \u22652). Randomisation was done using random sequence generation in block randomisation in a 1:1 ratio. Budesonide dry powder was delivered using a turbohaler at a dose of 800 \u03bcg per actuation. Participants were asked to take two inhalations twice a day until symptom resolution. The primary endpoint was COVID-19-related urgent care visit, including emergency department assessment or hospitalisation, analysed for both the per-protocol and intention-to-treat (ITT) populations. The secondary outcomes were self-reported clinical recovery (symptom resolution), viral symptoms measured using the Common Cold Questionnare (CCQ) and the InFLUenza Patient Reported Outcome Questionnaire (FLUPro), body temperature, blood oxygen saturations, and SARS-CoV-2 viral load. The trial was stopped early after independent statistical review concluded that study outcome would not change with further participant enrolment. This trial is registered with ClinicalTrials.gov, NCT04416399.\n\nFrom July 16 to Dec 9, 2020, 167 participants were recruited and assessed for eligibility. 21 did not meet eligibility criteria and were excluded. 146 participants were randomly assigned-73 to usual care and 73 to budesonide. For the per-protocol population (n=139), the primary outcome occurred in ten (14%) of 70 participants in the budesonide group and one (1%) of 69 participant in the usual care group (difference in proportions 0\u00b7131, 95% CI 0\u00b7043 to 0\u00b7218; p=0\u00b7004). For the ITT population, the primary outcome occurred in 11 (15%) participants in the usual care group and two (3%) participants in the budesonide group (difference in proportions 0\u00b7123, 95% CI 0\u00b7033 to 0\u00b7213; p=0\u00b7009). The number needed to treat with inhaled budesonide to reduce COVID-19 deterioration was eight. Clinical recovery was 1 day shorter in the budesonide group compared with the usual care group (median 7 days [95% CI 6 to 9] in the budesonide group vs 8 days [7 to 11] in the usual care group; log-rank test p=0\u00b7007). The mean proportion of days with a fever in the first 14 days was lower in the budesonide group (2%, SD 6) than the usual care group (8%, SD 18; Wilcoxon test p=0\u00b7051) and the proportion of participants with at least 1 day of fever was lower in the budesonide group when compared with the usual care group. As-needed antipyretic medication was required for fewer proportion of days in the budesonide group compared with the usual care group (27% [IQR 0-50] vs 50% [15-71]; p=0\u00b7025) Fewer participants randomly assigned to budesonide had persistent symptoms at days 14 and 28 compared with participants receiving usual care (difference in proportions 0\u00b7204, 95% CI 0\u00b7075 to 0\u00b7334; p=0\u00b7003). The mean total score change in the CCQ and FLUPro over 14 days was significantly better in the budesonide group compared with the usual care group (CCQ mean difference -0\u00b712, 95% CI -0\u00b721 to -0\u00b702 [p=0\u00b7016]; FLUPro mean difference -0\u00b710, 95% CI -0\u00b721 to -0\u00b700 [p=0\u00b7044]). Blood oxygen saturations and SARS-CoV-2 load, measured by cycle threshold, were not different between the groups. Budesonide was safe, with only five (7%) participants reporting self-limiting adverse events.\n\nEarly administration of inhaled budesonide reduced the likelihood of needing urgent medical care and reduced time to recovery after early COVID-19.\n\nNational Institute for Health Research Biomedical Research Centre and AstraZeneca.", "doi": "10.1016/S2213-2600(21)00160-0", "pmid": "33844996", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(21)00160-0"}, {"db": "ClinicalTrials.gov", "key": "NCT04416399"}], "notes": [], "created": "2021-04-13T10:27:27.629Z", "modified": "2021-04-13T10:29:15.226Z"}, {"entity": "publication", "iuid": "a6fc4c855acb4c7a8eeaf164395a1590", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6fc4c855acb4c7a8eeaf164395a1590.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6fc4c855acb4c7a8eeaf164395a1590"}}, "title": "Evaluating and optimizing COVID-19 vaccination policies: a case study of Sweden", "authors": [{"family": "Sj\u00f6din", "given": "Henrik", "initials": "H"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}, {"family": "Britton", "given": "Tom", "initials": "T"}], "type": "posted-content", "published": "2021-04-09", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.07.21255026", "pmid": null, "labels": {"Type: Preprint": null, "Category: Other": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-14T05:09:10.154Z", "modified": "2021-04-21T08:35:40.996Z"}, {"entity": "publication", "iuid": "1ddde94149764d01800ae09c16c2abed", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ddde94149764d01800ae09c16c2abed.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ddde94149764d01800ae09c16c2abed"}}, "title": "Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19.", "authors": [{"family": "Gaziano", "given": "Liam", "initials": "L"}, {"family": "Giambartolomei", "given": "Claudia", "initials": "C"}, {"family": "Pereira", "given": "Alexandre C", "initials": "AC"}, {"family": "Gaulton", "given": "Anna", "initials": "A"}, {"family": "Posner", "given": "Daniel C", "initials": "DC"}, {"family": "Swanson", "given": "Sonja A", "initials": "SA"}, {"family": "Ho", "given": "Yuk-Lam", "initials": "Y"}, {"family": "Iyengar", "given": "Sudha K", "initials": "SK"}, {"family": "Kosik", "given": "Nicole M", "initials": "NM"}, {"family": "Vujkovic", "given": "Marijana", "initials": "M"}, {"family": "Gagnon", "given": "David R", "initials": "DR"}, {"family": "Bento", "given": "A Patr\u00edcia", "initials": "AP"}, {"family": "Barrio-Hernandez", "given": "Inigo", "initials": "I"}, {"family": "R\u00f6nnblom", "given": "Lars", "initials": "L"}, {"family": "Hagberg", "given": "Niklas", "initials": "N"}, {"family": "Lundtoft", "given": "Christian", "initials": "C"}, {"family": "Langenberg", "given": "Claudia", "initials": "C"}, {"family": "Pietzner", "given": "Maik", "initials": "M"}, {"family": "Valentine", "given": "Dennis", "initials": "D"}, {"family": "Gustincich", "given": "Stefano", "initials": "S"}, {"family": "Tartaglia", "given": "Gian Gaetano", "initials": "GG"}, {"family": "Allara", "given": "Elias", "initials": "E"}, {"family": "Surendran", "given": "Praveen", "initials": "P"}, {"family": "Burgess", "given": "Stephen", "initials": "S"}, {"family": "Zhao", "given": "Jing Hua", "initials": "JH"}, {"family": "Peters", "given": "James E", "initials": "JE"}, {"family": "Prins", "given": "Bram P", "initials": "BP"}, {"family": "Angelantonio", "given": "Emanuele Di", "initials": "ED"}, {"family": "Devineni", "given": "Poornima", "initials": "P"}, {"family": "Shi", "given": "Yunling", "initials": "Y"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "DuVall", "given": "Scott L", "initials": "SL"}, {"family": "Garcon", "given": "Helene", "initials": "H"}, {"family": "Thomann", "given": "Lauren O", "initials": "LO"}, {"family": "Zhou", "given": "Jin J", "initials": "JJ"}, {"family": "Gorman", "given": "Bryan R", "initials": "BR"}, {"family": "Huffman", "given": "Jennifer E", "initials": "JE"}, {"family": "O'Donnell", "given": "Christopher J", "initials": "CJ"}, {"family": "Tsao", "given": "Philip S", "initials": "PS"}, {"family": "Beckham", "given": "Jean C", "initials": "JC"}, {"family": "Pyarajan", "given": "Saiju", "initials": "S"}, {"family": "Muralidhar", "given": "Sumitra", "initials": "S"}, {"family": "Huang", "given": "Grant D", "initials": "GD"}, {"family": "Ramoni", "given": "Rachel", "initials": "R"}, {"family": "Beltrao", "given": "Pedro", "initials": "P"}, {"family": "Danesh", "given": "John", "initials": "J"}, {"family": "Hung", "given": "Adriana M", "initials": "AM"}, {"family": "Chang", "given": "Kyong-Mi", "initials": "K"}, {"family": "Sun", "given": "Yan V", "initials": "YV"}, {"family": "Joseph", "given": "Jacob", "initials": "J"}, {"family": "Leach", "given": "Andrew R", "initials": "AR"}, {"family": "Edwards", "given": "Todd L", "initials": "TL"}, {"family": "Cho", "given": "Kelly", "initials": "K"}, {"family": "Gaziano", "given": "J Michael", "initials": "JM"}, {"family": "Butterworth", "given": "Adam S", "initials": "AS"}, {"family": "Casas", "given": "Juan P", "initials": "JP"}, {"family": "VA Million Veteran Program COVID-19 Science Initiative", "given": "", "initials": ""}], "type": "journal article", "published": "2021-04-09", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956", "volume": "27", "issue": "4", "pages": "668-676"}, "abstract": "Drug repurposing provides a rapid approach to meet the urgent need for therapeutics to address COVID-19. To identify therapeutic targets relevant to COVID-19, we conducted Mendelian randomization analyses, deriving genetic instruments based on transcriptomic and proteomic data for 1,263 actionable proteins that are targeted by approved drugs or in clinical phase of drug development. Using summary statistics from the Host Genetics Initiative and the Million Veteran Program, we studied 7,554 patients hospitalized with COVID-19 and >1 million controls. We found significant Mendelian randomization results for three proteins (ACE2, P = 1.6 \u00d7 10 -6; IFNAR2, P = 9.8 \u00d7 10-11 and IL-10RB, P = 2.3 \u00d7 10-14) using cis-expression quantitative trait loci genetic instruments that also had strong evidence for colocalization with COVID-19 hospitalization. To disentangle the shared expression quantitative trait loci signal for IL10RB and IFNAR2, we conducted phenome-wide association scans and pathway enrichment analysis, which suggested that IFNAR2 is more likely to play a role in COVID-19 hospitalization. Our findings prioritize trials of drugs targeting IFNAR2 and ACE2 for early management of COVID-19.", "doi": "10.1038/s41591-021-01310-z", "pmid": "33837377", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-021-01310-z"}, {"db": "GTEx project", "key": "https://gtexportal.org/home/.", "description": "GTEx project v.8 data"}, {"db": "CheMBL", "key": "https://www.ebi.ac.uk/chembl/", "description": "CheMBL database used to identify 1,263 human proteins as \u2018actionable\u2019 (therapeutic targets of approved or clinical-stage drugs) for SARS-COV2"}, {"db": "Fenland-SomaLogic protein GWAS data", "key": "https://omicscience.org/apps/covidpgwas/", "description": null}, {"db": "COVID-19 hospitalization data", "key": "https://www.covid19hg.org/", "description": "HGI COVID-19 hospitalization summary statistics"}, {"db": "phenoscanner", "key": "http://www.phenoscanner.medschl.cam.ac.uk/", "description": "PhenoScanner results for searching proteins, traits and diseases"}], "notes": [], "created": "2021-04-12T16:09:55.811Z", "modified": "2021-11-18T09:22:55.307Z"}, {"entity": "publication", "iuid": "e95d0be8d9a041e7bd1859fa613ee7cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e95d0be8d9a041e7bd1859fa613ee7cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e95d0be8d9a041e7bd1859fa613ee7cc"}}, "title": "Safety of Esophageal Cancer Surgery During the First Wave of the COVID-19 Pandemic in Europe: A Multicenter Study.", "authors": [{"family": "Borgstein", "given": "Alexander B J", "initials": "ABJ"}, {"family": "Brunner", "given": "Stefanie", "initials": "S"}, {"family": "Hayami", "given": "Masaru", "initials": "M"}, {"family": "Moons", "given": "Johnny", "initials": "J"}, {"family": "Fuchs", "given": "Hans", "initials": "H"}, {"family": "Eshuis", "given": "Wietse J", "initials": "WJ"}, {"family": "Gisbertz", "given": "Suzanne S", "initials": "SS"}, {"family": "Bruns", "given": "Christiane J", "initials": "CJ"}, {"family": "Nafteux", "given": "Philippe", "initials": "P"}, {"family": "Nilsson", "given": "Magnus", "initials": "M"}, {"family": "Schr\u00f6der", "given": "Wolfgang", "initials": "W"}, {"family": "van Berge Henegouwen", "given": "Mark I", "initials": "MI"}], "type": "journal article", "published": "2021-04-08", "journal": {"title": "Ann Surg Oncol", "issn": "1534-4681", "volume": null, "issue": null, "issn-l": null}, "abstract": "Many hospitals postponed elective surgical care during the first wave of the coronavirus disease 2019 (COVID-19) pandemic. Some centers continued elective surgery, including esophageal cancer surgery, with the use of preoperative screening methods; however, there is no evidence supporting the safety of this strategy as postoperative outcomes after esophageal cancer surgery during the COVID-19 pandemic have not yet been investigated.\n\nThis multicenter study in four European tertiary esophageal cancer referral centers included consecutive adult patients undergoing elective esophageal cancer surgery from a prospectively maintained database in a COVID-19 pandemic cohort (1 March 2020-31 May 2020) and a control cohort (1 October 2019-29 February 2020). The primary outcome was the rate of respiratory failure requiring mechanical ventilation.\n\nThe COVID-19 cohort consisted of 139 patients, versus 168 patients in the control cohort. There was no difference in the rate of respiratory failure requiring mechanical ventilation (13.7% vs. 8.3%, p = 0.127) and number of pulmonary complications (32.4% vs. 29.9%, p = 0.646) between the COVID-19 cohort and the control cohort. Overall, postoperative morbidity and mortality rates were comparable between both cohorts. History taking and reverse transcription polymerase chain reaction (RT-PCR) were used as preoperative screening methods to detect a possible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in all centers. No patients were diagnosed with COVID-19 pre- or postoperatively.\n\nEsophageal cancer surgery during the first wave of the COVID-19 pandemic was not associated with an increase in pulmonary complications as no patients were diagnosed with COVID-19. Esophageal cancer surgery can be performed safely with the use of adequate preoperative SARS-CoV-2 screening methods.", "doi": "10.1245/s10434-021-09886-z", "pmid": "33830357", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1245/s10434-021-09886-z"}], "notes": [], "created": "2021-04-09T16:45:24.369Z", "modified": "2021-04-09T16:45:24.393Z"}, {"entity": "publication", "iuid": "0c3bea1d568149e89b08f349a0786114", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c3bea1d568149e89b08f349a0786114.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c3bea1d568149e89b08f349a0786114"}}, "title": "Platelet count rose while D-dimer levels dropped as deaths and thrombosis declined, an observational study on anticoagulation shift in COVID-19.", "authors": [{"family": "Sj\u00f6str\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Wers\u00e4ll", "given": "Johanna", "initials": "J"}, {"family": "Warnqvist", "given": "Anna", "initials": "A"}, {"family": "Farm", "given": "Maria", "initials": "M"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Oldner", "given": "Anders", "initials": "A"}, {"family": "\u00c5gren", "given": "Anna", "initials": "A"}, {"family": "Antovic", "given": "Jovan P", "initials": "JP"}, {"family": "Bruzelius", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-04-08", "journal": {"title": "Thromb Haemost", "issn": "2567-689X", "volume": null, "issue": null, "issn-l": "0340-6245"}, "abstract": "High levels of D-dimer and low platelet counts are associated with poor outcome in COVID-19. As anticoagulation appeared to improve survival, hospital-wide recommendations regarding higher doses of anticoagulation was implemented 4/9/2020.\n\nTo investigate if trends in D-dimer levels and platelet counts associated with death, thrombosis, and the shift in anticoagulation.\n\nRetrospective cohort study of 429 patients with COVID-19 at Karolinska University Hospital. Information on D-dimer levels and platelet counts was obtained from laboratory databases and clinical data from medical records.\n\nThirty-day mortality and thrombosis rate was 19% and 18%, respectively. Pulmonary embolism was common; 65/83 (78%). Increased D-dimer levels the first week in hospital were significantly associated with death and thrombosis (OR 6.06; 95% Cl 2.10-17.5, and 3.11; 95% CI 1.20-8.10, respectively). If platelet count increased more than 35\u00d7109/L per day, the mortality and thrombotic risk decreased (OR 0.16; 95% CI 0.06-0.41, and OR 0.36; 95% CI 0.17-0.80). After implementation of updated hospital-wide recommendations, the daily mean significantly decreased regarding D-dimer levels while platelet counts rose; -1.93; 95% CI -1.00-2.87 mg/L FEU and 65; 95% CI 54-76 \u00d7109/L and significant risk reductions for death and thrombosis were observed; OR 0.48; 95% CI 0.25-0.92 and 0.35; 95% CI 0.17-0.72.\n\nIn contrast to D-dimer levels, increase of platelet count over the first week in-hospital was associated with improved survival and reduced thrombotic risk. The daily mean levels of D-dimer dropped while the platelet counts rose, coinciding with increased anticoagulation and a decline in thrombotic burden and mortality.", "doi": "10.1055/a-1477-3829", "pmid": "33831964", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-09T16:47:21.673Z", "modified": "2021-04-09T16:47:21.683Z"}, {"entity": "publication", "iuid": "7419a7484d754917952a7b310334a8ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7419a7484d754917952a7b310334a8ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7419a7484d754917952a7b310334a8ef"}}, "title": "Estimation of Excess Mortality and Years of Life Lost to COVID-19 in Norway and Sweden between March and November 2020.", "authors": [{"family": "Rypdal", "given": "Martin", "initials": "M", "orcid": "0000-0003-0053-665X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eea43d9f775e446680aff49c4caf4a6e.json"}}, {"family": "Rypdal", "given": "Kristoffer", "initials": "K", "orcid": "0000-0001-9306-5441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf10bf2f114a497e990038fd1c8d9248.json"}}, {"family": "L\u00f8vsletten", "given": "Ola", "initials": "O", "orcid": "0000-0001-9483-9621", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3912eef1009b48c69b67fd71687b9776.json"}}, {"family": "S\u00f8rbye", "given": "Sigrunn Holbek", "initials": "SH", "orcid": "0000-0002-5818-1508", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4ca8694ab6947bfa1e8f7fdc9d084ea.json"}}, {"family": "Ytterstad", "given": "Elinor", "initials": "E", "orcid": "0000-0002-1203-1491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33d836747a854f1592d920fa05bf7031.json"}}, {"family": "Bianchi", "given": "Filippo Maria", "initials": "FM", "orcid": "0000-0002-7145-3846", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cc4d12290c64a3f8b406347f52f8c9b.json"}}], "type": "journal article", "published": "2021-04-08", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "8", "issn-l": null}, "abstract": "We estimate the weekly excess all-cause mortality in Norway and Sweden, the years of life lost (YLL) attributed to COVID-19 in Sweden, and the significance of mortality displacement. We computed the expected mortality by taking into account the declining trend and the seasonality in mortality in the two countries over the past 20 years. From the excess mortality in Sweden in 2019/20, we estimated the YLL attributed to COVID-19 using the life expectancy in different age groups. We adjusted this estimate for possible displacement using an auto-regressive model for the year-to-year variations in excess mortality. We found that excess all-cause mortality over the epidemic year, July 2019 to July 2020, was 517 (95%CI = (12, 1074)) in Norway and 4329 [3331, 5325] in Sweden. There were 255 COVID-19 related deaths reported in Norway, and 5741 in Sweden, that year. During the epidemic period of 11 March-11 November, there were 6247 reported COVID-19 deaths and 5517 (4701, 6330) excess deaths in Sweden. We estimated that the number of YLL attributed to COVID-19 in Sweden was 45,850 [13,915, 80,276] without adjusting for mortality displacement and 43,073 (12,160, 85,451) after adjusting for the displacement accounted for by the auto-regressive model. In conclusion, we find good agreement between officially recorded COVID-19 related deaths and all-cause excess deaths in both countries during the first epidemic wave and no significant mortality displacement that can explain those deaths.", "doi": "10.3390/ijerph18083913", "pmid": "33917872", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8068261"}, {"db": "pii", "key": "ijerph18083913"}], "notes": [], "created": "2023-01-13T13:43:05.800Z", "modified": "2023-01-13T13:43:07.279Z"}, {"entity": "publication", "iuid": "7f23907c2d4842f3afbc5d09b9b23b51", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f23907c2d4842f3afbc5d09b9b23b51.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f23907c2d4842f3afbc5d09b9b23b51"}}, "title": "Detection of SARS-CoV-2 RNA in the Danube River in Serbia associated with the discharge of untreated wastewaters.", "authors": [{"family": "Kolarevi\u0107", "given": "Stoimir", "initials": "S"}, {"family": "Micsinai", "given": "Adrienn", "initials": "A"}, {"family": "Sz\u00e1nt\u00f3-Eg\u00e9sz", "given": "R\u00e9ka", "initials": "R"}, {"family": "Luk\u00e1cs", "given": "Alena", "initials": "A"}, {"family": "Kra\u010dun-Kolarevi\u0107", "given": "Margareta", "initials": "M"}, {"family": "Lundy", "given": "Lian", "initials": "L"}, {"family": "Kirschner", "given": "Alexander K T", "initials": "AKT"}, {"family": "Farnleitner", "given": "Andreas H", "initials": "AH"}, {"family": "Djukic", "given": "Aleksandar", "initials": "A"}, {"family": "\u010coli\u0107", "given": "Jasna", "initials": "J"}, {"family": "Nenin", "given": "Tanja", "initials": "T"}, {"family": "Sunjog", "given": "Karolina", "initials": "K"}, {"family": "Paunovi\u0107", "given": "Momir", "initials": "M"}], "type": "journal article", "published": "2021-04-08", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "issn-l": "0048-9697", "volume": "783", "issue": null, "pages": "146967"}, "abstract": "In Serbia less than 13% of collected municipal wastewaters is being treated before their release in the environment. This includes all municipal wastewater discharges from Belgrade (capital city of Serbia; population 1,700,000). Previous research has identified the impacts of raw wastewater discharges from Belgrade on the Danube River, and this study investigated if such discharges also provided a pathway for SARS-CoV-2 RNA material. Samples were collected during the most critical circumstances that occurred so far within the COVID-19 pandemics in Serbia. Grab and composite samples were collected in December 2020, during the peak of the third wave (in terms of reported cases) at the site which receives the wastewater loads in Belgrade. Grab samples collected upstream and downstream of Belgrade were also analyzed. RNA was quantified using RT-qPCR with primer sets targeting nucleocapsid (N1 and N2) and envelope (E) protein genes. SARS-CoV-2 RNA (5.97 \u00d7 10 3 to 1.32 \u00d7 104 copies/L) was detected only in samples collected at the site strongly impacted by the wastewaters where all three applied primer sets gave positive signals. Determined concentrations correspond to those reported in wastewater influents sampled at treatment plants in other countries indicating an epidemiological indicator function of used approach for rivers with high pollution loads in countries with poor wastewater treatment.", "doi": "10.1016/j.scitotenv.2021.146967", "pmid": "33865136", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(21)02037-4"}], "notes": [], "created": "2021-04-19T10:40:03.905Z", "modified": "2021-06-21T14:49:12.299Z"}, {"entity": "publication", "iuid": "d2d1266ccd71494e829e3db102c467fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d2d1266ccd71494e829e3db102c467fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d2d1266ccd71494e829e3db102c467fa"}}, "title": "Acceptability of COVID-19 Vaccine in Africa", "authors": [{"family": "Sevidzem Wirsiy", "given": "Frankline", "initials": "F"}, {"family": "Nkfusai", "given": "Ngwayu Claude", "initials": "NC"}, {"family": "Ebot Ako-Arrey", "given": "Denis", "initials": "D"}, {"family": "Kenfack Dongmo", "given": "Esther", "initials": "E"}, {"family": "Titu Manjong", "given": "Florence", "initials": "F"}, {"family": "Nambile Cumber", "given": "Samuel", "initials": "S"}], "type": "journal-article", "published": "2021-04-08", "journal": {"title": "Int J MCH AIDS", "issn": "2161-864X", "volume": "10", "issue": "1", "pages": "134-138", "issn-l": null}, "abstract": null, "doi": "10.21106/ijma.482", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-04-20T17:55:23.466Z", "modified": "2021-04-20T17:55:23.489Z"}, {"entity": "publication", "iuid": "6c44a627afce4e37869d9a48b8ae9616", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c44a627afce4e37869d9a48b8ae9616.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c44a627afce4e37869d9a48b8ae9616"}}, "title": "Transmission of SARS-Cov-2 and other enveloped viruses to the environment through protective gear: a brief review.", "authors": [{"family": "Petrosino", "given": "Francesco", "initials": "F"}, {"family": "Mukherjee", "given": "Debolina", "initials": "D"}, {"family": "Coppola", "given": "Gerardo", "initials": "G"}, {"family": "Gaudio", "given": "Maria Teresa", "initials": "MT"}, {"family": "Curcio", "given": "Stefano", "initials": "S"}, {"family": "Calabro", "given": "Vincenza", "initials": "V"}, {"family": "Marra", "given": "Francesco", "initials": "F"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Pal", "given": "Umapada", "initials": "U"}, {"family": "Kh\u00e9lifi", "given": "Nabil", "initials": "N"}, {"family": "Chakraborty", "given": "Sudip", "initials": "S"}], "type": "journal article", "published": "2021-04-07", "journal": {"title": "EuroMediterr J Environ Integr", "issn": "2365-7448", "volume": "6", "issue": "2", "pages": "48", "issn-l": null}, "abstract": "Over the past two decades, several deadly viral epidemics have emerged, which have placed humanity in danger. Previous investigations have suggested that viral diseases can spread through contaminants or contaminated surfaces. The transmission of viruses via polluted surfaces relies upon their capacity to maintain their infectivity while they are in the environment. Here, a range of materials that are widely used to manufacture personal protective equipment (PPE) are summarized, as these offer effective disinfection solutions and are the environmental variables that influence virus survival. Infection modes and prevention as well as disinfection and PPE disposal strategies are discussed. A coronavirus-like enveloped virus can live in the environment after being discharged from a host organism until it infects another healthy individual. Transmission of enveloped viruses such as SARS-CoV-2 can occur even without direct contact, although detailed knowledge of airborne routes and other indirect transmission paths is still lacking. Ground transmission of viruses is also possible via wastewater discharges. While enveloped viruses can contaminate potable water and wastewater through human excretions such as feces and droplets, careless PPE disposal can also lead to their transmission into our environment. This paper also highlights the possibility that viruses can be transmitted into the environment from PPE kits used by healthcare and emergency service personnel. A simulation-based approach was developed to understand the transport mechanism for coronavirus and similar enveloped viruses in the environment through porous media, and preliminary results from this model are presented here. Those results indicate that viruses can move through porous soil and eventually contaminate groundwater. This paper therefore underlines the importance of proper PPE disposal by healthcare workers in the Mediterranean region and around the world.", "doi": "10.1007/s41207-021-00251-w", "pmid": "33842691", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "251"}, {"db": "pmc", "key": "PMC8024444"}], "notes": [], "created": "2021-04-13T09:37:59.682Z", "modified": "2021-04-13T10:15:55.648Z"}, {"entity": "publication", "iuid": "38721962da8b47b7ab73d1b984f6f0e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38721962da8b47b7ab73d1b984f6f0e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38721962da8b47b7ab73d1b984f6f0e8"}}, "title": "Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19", "authors": [{"family": "Klaric", "given": "Lucija", "initials": "L"}, {"family": "Gisby", "given": "Jack S", "initials": "JS"}, {"family": "Papadaki", "given": "Artemis", "initials": "A"}, {"family": "Muckian", "given": "Marisa D", "initials": "MD"}, {"family": "Macdonald-Dunlop", "given": "Erin", "initials": "E"}, {"family": "Zhao", "given": "Jing Hua", "initials": "JH"}, {"family": "Tokolyi", "given": "Alex", "initials": "A"}, {"family": "Persyn", "given": "Elodie", "initials": "E"}, {"family": "Pairo-Castineira", "given": "Erola", "initials": "E"}, {"family": "Morris", "given": "Andrew P", "initials": "AP"}, {"family": "Kalnapenkis", "given": "Anette", "initials": "A"}, {"family": "Richmond", "given": "Anne", "initials": "A"}, {"family": "Landini", "given": "Arianna", "initials": "A"}, {"family": "Hedman", "given": "\u00c5sa K", "initials": "\u00c5K"}, {"family": "Prins", "given": "Bram", "initials": "B"}, {"family": "Zanetti", "given": "Daniela", "initials": "D"}, {"family": "Wheeler", "given": "Eleanor", "initials": "E"}, {"family": "Kooperberg", "given": "Charles", "initials": "C"}, {"family": "Yao", "given": "Chen", "initials": "C"}, {"family": "Petrie", "given": "John R", "initials": "JR"}, {"family": "Fu", "given": "Jingyuan", "initials": "J"}, {"family": "Folkersen", "given": "Lasse", "initials": "L"}, {"family": "Walker", "given": "Mark", "initials": "M"}, {"family": "Magnusson", "given": "Martin", "initials": "M"}, {"family": "Eriksson", "given": "Niclas", "initials": "N"}, {"family": "Mattsson-Carlgren", "given": "Niklas", "initials": "N"}, {"family": "Timmers", "given": "Paul R H J", "initials": "PRHJ"}, {"family": "Hwang", "given": "Shih Jen", "initials": "SJ"}, {"family": "Enroth", "given": "Stefan", "initials": "S"}, {"family": "Gustafsson", "given": "Stefan", "initials": "S"}, {"family": "Vosa", "given": "Urmo", "initials": "U"}, {"family": "Chen", "given": "Yan", "initials": "Y"}, {"family": "Siegbahn", "given": "Agneta", "initials": "A"}, {"family": "Reiner", "given": "Alexander", "initials": "A"}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Thorand", "given": "Barbara", "initials": "B"}, {"family": "Gigante", "given": "Bruna", "initials": "B"}, {"family": "Hayward", "given": "Caroline", "initials": "C"}, {"family": "Herder", "given": "Christian", "initials": "C"}, {"family": "Gieger", "given": "Christian", "initials": "C"}, {"family": "Langenberg", "given": "Claudia", "initials": "C"}, {"family": "Levy", "given": "Daniel", "initials": "D"}, {"family": "Zhernakova", "given": "Daria V", "initials": "DV"}, {"family": "Smith", "given": "J Gustav", "initials": "JG"}, {"family": "Campbell", "given": "Harry", "initials": "H"}, {"family": "Sundstrom", "given": "Johan", "initials": "J"}, {"family": "Danesh", "given": "John", "initials": "J"}, {"family": "Micha\u00eblsson", "given": "Karl", "initials": "K"}, {"family": "Suhre", "given": "Karsten", "initials": "K"}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Wallentin", "given": "Lars", "initials": "L"}, {"family": "Padyukov", "given": "Leonid", "initials": "L"}, {"family": "Land\u00e9n", "given": "Mikael", "initials": "M"}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ"}, {"family": "G\u00f6teson", "given": "Andreas", "initials": "A"}, {"family": "Hansson", "given": "Oskar", "initials": "O"}, {"family": "Eriksson", "given": "Per", "initials": "P"}, {"family": "Strawbridge", "given": "Rona J", "initials": "RJ"}, {"family": "Assimes", "given": "Themistocles L", "initials": "TL"}, {"family": "Esko", "given": "Tonu", "initials": "T"}, {"family": "Gyllensten", "given": "Ulf", "initials": "U"}, {"family": "Baillie", "given": "J Kenneth", "initials": "JK"}, {"family": "Paul", "given": "Dirk S", "initials": "DS"}, {"family": "Joshi", "given": "Peter K", "initials": "PK"}, {"family": "Butterworth", "given": "Adam S", "initials": "AS"}, {"family": "M\u00e4larstig", "given": "Anders", "initials": "A"}, {"family": "Pirastu", "given": "Nicola", "initials": "N"}, {"family": "Wilson", "given": "James F", "initials": "JF"}, {"family": "Peters", "given": "James E", "initials": "JE"}], "type": "posted-content", "published": "2021-04-07", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.01.21254789", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "URL", "key": "https://www.medrxiv.org/node/330092.external-links.html", "description": "All data are available in the paper and supplementary material"}], "notes": [], "created": "2021-04-09T17:20:45.937Z", "modified": "2021-11-18T12:28:05.919Z"}, {"entity": "publication", "iuid": "009ec6accb344739ba8d2b672015151e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/009ec6accb344739ba8d2b672015151e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/009ec6accb344739ba8d2b672015151e"}}, "title": "Impact of COVID-19 on social media as perceived by the oncology community: results from a survey in collaboration with the European Society for Medical Oncology (ESMO) and the OncoAlert Network.", "authors": [{"family": "Morgan", "given": "G", "initials": "G"}, {"family": "Tagliamento", "given": "M", "initials": "M"}, {"family": "Lambertini", "given": "M", "initials": "M"}, {"family": "Devnani", "given": "B", "initials": "B"}, {"family": "Westphalen", "given": "B", "initials": "B"}, {"family": "Dienstmann", "given": "R", "initials": "R"}, {"family": "Bozovic-Spasojevic", "given": "I", "initials": "I"}, {"family": "Calles", "given": "A", "initials": "A"}, {"family": "Criscitiello", "given": "C", "initials": "C"}, {"family": "Curioni", "given": "A", "initials": "A"}, {"family": "Garcia", "given": "A M", "initials": "AM"}, {"family": "Lamarca", "given": "A", "initials": "A"}, {"family": "Pilotto", "given": "S", "initials": "S"}, {"family": "Scheffler", "given": "M", "initials": "M"}, {"family": "Strijbos", "given": "M", "initials": "M"}, {"family": "Wong", "given": "R", "initials": "R"}, {"family": "de Azambuja", "given": "E", "initials": "E"}, {"family": "Peters", "given": "S", "initials": "S"}], "type": "journal article", "published": "2021-04-07", "journal": {"title": "ESMO Open", "issn": "2059-7029", "volume": "6", "issue": "2", "pages": "100104", "issn-l": null}, "abstract": "The COVID-19 pandemic has impacted all aspects of modern-day oncology, including how stakeholders communicate through social media. We surveyed oncology stakeholders in order to assess their attitudes pertaining to social media and how it has been affected during the pandemic.\n\nA 40-item survey was distributed to stakeholders from 8 July to 22 July 2020 and was promoted through the European Society for Medical Oncology (ESMO) and the OncoAlert Network.\n\nOne thousand and seventy-six physicians and stakeholders took part in the survey. In total, 57.3% of respondents were medical oncologists, 50.6% aged <40 years, 50.8% of female gender and mostly practicing in Europe (51.5%). More than 90% of respondents considered social media a useful tool for distributing scientific information and for education. Most used social media to stay up to date on cancer care in general (62.5%) and cancer care during COVID-19 (61%) given the constant flow of information. Respondents also used social media to interact with other oncologists (78.8%) and with patients (34.4%). Overall, 61.1% of respondents were satisfied with the role that social media was playing during the COVID-19 pandemic. On the other hand, 41.1% of respondents reported trouble in discriminating between credible and less credible information and 30% stated social networks were a source of stress. For this reason, one-third of respondents reduced its use during the COVID-19 pandemic. Regarding meeting attendance, a total of 59.1% of responding physicians preferred in-person meetings to virtual ones, and 51.8% agreed that virtual meetings and social distancing could hamper effective collaboration.\n\nSocial media has a useful role in supporting cancer care and professional engagement in oncology. Although one-third of respondents reported reduced use of social media due to stress during the COVID-19 pandemic, the majority found social media useful to keep up to date and were satisfied with the role social media was playing during the pandemic.", "doi": "10.1016/j.esmoop.2021.100104", "pmid": "33838532", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2059-7029(21)00061-2"}], "notes": [], "created": "2021-04-12T15:37:58.350Z", "modified": "2021-04-12T15:37:58.364Z"}, {"entity": "publication", "iuid": "3b2eb5d7df4c423fb1850f747e0c19ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b2eb5d7df4c423fb1850f747e0c19ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b2eb5d7df4c423fb1850f747e0c19ee"}}, "title": "Extracorporeal Membrane Oxygenation in Patients With COVID-19: An International Multicenter Cohort Study.", "authors": [{"family": "Raasveld", "given": "Senta Jorinde", "initials": "SJ"}, {"family": "Delnoij", "given": "Thijs S R", "initials": "TSR"}, {"family": "Broman", "given": "Lars M", "initials": "LM"}, {"family": "Lansink-Hartgring", "given": "Annemieke Oude", "initials": "AO"}, {"family": "Hermans", "given": "Greet", "initials": "G"}, {"family": "De Troy", "given": "Erwin", "initials": "E"}, {"family": "Taccone", "given": "Fabio S", "initials": "FS"}, {"family": "Quintana Diaz", "given": "Manuel", "initials": "M"}, {"family": "van der Velde", "given": "Franciska", "initials": "F"}, {"family": "Miranda", "given": "Dinis Dos Reis", "initials": "DDR"}, {"family": "Scholten", "given": "Erik", "initials": "E"}, {"family": "ETALON Study Group", "given": "", "initials": ""}, {"family": "Vlaar", "given": "Alexander P J", "initials": "APJ"}], "type": "journal article", "published": "2021-04-07", "journal": {"title": "J Intensive Care Med", "issn": "1525-1489", "volume": null, "issue": null, "pages": "8850666211007063", "issn-l": null}, "abstract": "To report and compare the characteristics and outcomes of COVID-19 patients on extracorporeal membrane oxygenation (ECMO) to non-COVID-19 acute respiratory distress syndrome (ARDS) patients on ECMO.\n\nWe performed an international retrospective study of COVID-19 patients on ECMO from 13 intensive care units from March 1 to April 30, 2020. Demographic data, ECMO characteristics and clinical outcomes were collected. The primary outcome was to assess the complication rate and 28-day mortality; the secondary outcome was to compare patient and ECMO characteristics between COVID-19 patients on ECMO and non-COVID-19 related ARDS patients on ECMO (non-COVID-19; January 1, 2018 until July 31, 2019).\n\nDuring the study period 71 COVID-19 patients received ECMO, mostly veno-venous, for a median duration of 13 days (IQR 7-20). ECMO was initiated at 5 days (IQR 3-10) following invasive mechanical ventilation. Median PaO 2/FiO2 ratio prior to initiation of ECMO was similar in COVID-19 patients (58 mmHg [IQR 46-76]) and non-COVID-19 patients (53 mmHg [IQR 44-66]), the latter consisting of 48 patients. 28-day mortality was 37% in COVID-19 patients and 27% in non-COVID-19 patients. However, Kaplan-Meier curves showed that after a 100-day follow-up this non-significant difference resolves. Non-surviving COVID-19 patients were more acidotic prior to initiation ECMO, had a shorter ECMO run and fewer received muscle paralysis compared to survivors.\n\nNo significant differences in outcomes were found between COVID-19 patients on ECMO and non-COVID-19 ARDS patients on ECMO. This suggests that ECMO could be considered as a supportive therapy in case of refractory respiratory failure in COVID-19.", "doi": "10.1177/08850666211007063", "pmid": "33823709", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-09T16:37:56.539Z", "modified": "2021-04-09T16:38:10.777Z"}, {"entity": "publication", "iuid": "3b12c54aa1004277b287b04be74241cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b12c54aa1004277b287b04be74241cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b12c54aa1004277b287b04be74241cf"}}, "title": "Evaluation of 11 SARS-CoV-2 antibody tests by using samples from patients with defined IgG antibody titers.", "authors": [{"family": "Lagerqvist", "given": "Nina", "initials": "N"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Verner-Carlsson", "given": "Jenny", "initials": "J"}, {"family": "Olausson", "given": "Mikaela", "initials": "M"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Wigren Bystr\u00f6m", "given": "Julia", "initials": "J"}, {"family": "Monsen", "given": "Tor", "initials": "T"}, {"family": "Forsell", "given": "Mattias", "initials": "M"}, {"family": "Eriksson", "given": "Jenny", "initials": "J"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Ljunggren", "given": "Joel", "initials": "J"}, {"family": "Repo", "given": "Johanna", "initials": "J"}, {"family": "Kjerstadius", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Muradrasoli", "given": "Shaman", "initials": "S"}, {"family": "Brytting", "given": "Mia", "initials": "M"}, {"family": "Szekely Bj\u00f6rndal", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "\u00c5kerlund", "given": "Thomas", "initials": "T"}, {"family": "Nilsson", "given": "Charlotta", "initials": "C"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2021-04-07", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "7614"}, "abstract": "We evaluated the performance of 11 SARS-CoV-2 antibody tests using a reference set of heat-inactivated samples from 278 unexposed persons and 258 COVID-19 patients, some of whom contributed serial samples. The reference set included samples with a variation in SARS-CoV-2 IgG antibody titers, as determined by an in-house immunofluorescence assay (IFA). The five evaluated rapid diagnostic tests had a specificity of 99.0% and a sensitivity that ranged from 56.3 to 81.6% and decreased with low IFA IgG titers. The specificity was > 99% for five out of six platform-based tests, and when assessed using samples collected \u2265 22 days after symptom onset, two assays had a sensitivity of > 96%. These two assays also detected samples with low IFA titers more frequently than the other assays. In conclusion, the evaluated antibody tests showed a heterogeneity in their performances and only a few tests performed well with samples having low IFA IgG titers, an important aspect for diagnostics and epidemiological investigations.", "doi": "10.1038/s41598-021-87289-6", "pmid": "33828214", "labels": {"Type: Journal article": null, "Category: Other": null, "Funder: VR": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-87289-6"}], "notes": [], "created": "2021-04-09T16:40:58.037Z", "modified": "2021-09-28T13:28:38.352Z"}, {"entity": "publication", "iuid": "524d8edfc6a445d8af1393abeba6c868", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/524d8edfc6a445d8af1393abeba6c868.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/524d8edfc6a445d8af1393abeba6c868"}}, "title": "Uneven growth of SARS-CoV-2 clones evidenced by more than 500,000 whole-genome sequences", "authors": [{"family": "Zeng", "given": "Hong Li", "initials": "HL"}, {"family": "Liu", "given": "Yue", "initials": "Y"}, {"family": "Thorell", "given": "Kaisa", "initials": "K"}, {"family": "Norden", "given": "Rickard", "initials": "R"}, {"family": "Aurell", "given": "Erik", "initials": "E"}], "type": "posted-content", "published": "2021-04-06", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.06.437914", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Genomics & transcriptomics": null}, "xrefs": [], "notes": [], "created": "2021-04-08T18:32:33.788Z", "modified": "2021-04-13T14:01:53.008Z"}, {"entity": "publication", "iuid": "53ae2f2924db4176962ce29761d86697", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53ae2f2924db4176962ce29761d86697.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53ae2f2924db4176962ce29761d86697"}}, "title": "The Up state of the SARS-COV-2 Spike homotrimer favors an increased virulence for new variants", "authors": [{"family": "Giron", "given": "Carolina Corr\u00eaa", "initials": "CC"}, {"family": "Laaksonen", "given": "Aatto", "initials": "A"}, {"family": "da Silva", "given": "Fernando Lu\u00eds Barroso", "initials": "FLB"}], "type": "posted-content", "published": "2021-04-06", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.05.438465", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-08T18:35:24.719Z", "modified": "2021-04-15T18:28:09.307Z"}, {"entity": "publication", "iuid": "a1911234966d4ac7babf41bc2fbfb0b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a1911234966d4ac7babf41bc2fbfb0b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a1911234966d4ac7babf41bc2fbfb0b0"}}, "title": "The Other Side of SARS-CoV-2 Infection: Neurological Sequelae in Patients.", "authors": [{"family": "Alonso-Bellido", "given": "Isabel M", "initials": "IM"}, {"family": "Bachiller", "given": "Sara", "initials": "S"}, {"family": "V\u00e1zquez", "given": "Guillermo", "initials": "G"}, {"family": "Cruz-Hern\u00e1ndez", "given": "Luis", "initials": "L"}, {"family": "Mart\u00ednez", "given": "Emilio", "initials": "E"}, {"family": "Ruiz-Mateos", "given": "Ezequiel", "initials": "E"}, {"family": "Deierborg", "given": "Tomas", "initials": "T"}, {"family": "Venero", "given": "Jos\u00e9 L", "initials": "JL"}, {"family": "Real", "given": "Luis M", "initials": "LM"}, {"family": "Ruiz", "given": "Roc\u00edo", "initials": "R"}], "type": "journal article", "published": "2021-04-06", "journal": {"title": "Front Aging Neurosci", "issn": "1663-4365", "issn-l": null, "volume": "13", "issue": null, "pages": "632673"}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the globe causing coronavirus disease 2019 (COVID-19). Because it affects the respiratory system, common symptoms are cough and breathing difficulties with fever and fatigue. Also, some cases progress to acute respiratory distress syndrome (ARDS). The acute phase of COVID-19 has been also related to nervous system symptoms, including loss of taste and smell as well as encephalitis and cerebrovascular disorders. However, it remains unclear if neurological complications are due to the direct viral infection of the nervous system, or they appear as a consequence of the immune reaction against the virus in patients who presented pre-existing deficits or had a certain detrimental immune response. Importantly, the medium and long-term consequences of the infection by SARS-CoV-2 in the nervous system remain at present unknown. This review article aims to give an overview of the current neurological symptoms associated with COVID-19, as well as attempting to provide an insight beyond the acute affectation.", "doi": "10.3389/fnagi.2021.632673", "pmid": "33889082", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8055831"}], "notes": [], "created": "2021-04-29T16:10:40.146Z", "modified": "2021-04-29T16:11:31.138Z"}, {"entity": "publication", "iuid": "5898be945cfd4aea99cd1a994bb2ba1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5898be945cfd4aea99cd1a994bb2ba1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5898be945cfd4aea99cd1a994bb2ba1d"}}, "title": "Perceived Effectiveness, Restrictiveness, and Compliance with Containment Measures against the Covid-19 Pandemic: An International Comparative Study in 11 Countries", "authors": [{"family": "Georgieva", "given": "Irina", "initials": "I"}, {"family": "Lantta", "given": "Tella", "initials": "T"}, {"family": "Lickiewicz", "given": "Jakub", "initials": "J"}, {"family": "Pekara", "given": "Jaroslav", "initials": "J"}, {"family": "Wikman", "given": "Sofia", "initials": "S"}, {"family": "Losevi\u010da", "given": "Marina", "initials": "M"}, {"family": "Raveesh", "given": "Bevinahalli", "initials": "B"}, {"family": "Mihai", "given": "Adriana", "initials": "A"}, {"family": "Lepping", "given": "Peter", "initials": "P"}], "type": "journal-article", "published": "2021-04-06", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "7", "pages": "3806"}, "abstract": "National governments took action to delay the transmission of the coronavirus (SARS-CoV-2) by implementing different containment measures. We developed an online survey that included 44 different containment measures. We aimed to assess how effective citizens perceive these measures, which measures are perceived as violation of citizens' personal freedoms, which opinions and demographic factors have an effect on compliance with the measures, and what governments can do to most effectively improve citizens' compliance. The survey was disseminated in 11 countries: UK, Belgium, Netherlands, Bulgaria, Czech Republic, Finland, India, Latvia, Poland, Romania, and Sweden. We acquired 9543 unique responses. Our findings show significant differences across countries in perceived effectiveness, restrictiveness, and compliance. Governments that suffer low levels of trust should put more effort into persuading citizens, especially men, in the effectiveness of the proposed measures. They should provide financial compensation to citizens who have lost their job or income due to the containment measures to improve measure compliance. Policymakers should implement the least restrictive and most effective public health measures first during pandemic emergencies instead of implementing a combination of many restrictive measures, which has the opposite effect on citizens' adherence and undermines human rights.", "doi": "10.3390/ijerph18073806", "pmid": "33917334", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-04-27T15:00:06.043Z", "modified": "2021-06-18T15:51:54.429Z"}, {"entity": "publication", "iuid": "f76c3e11e2094a3db5ca89e4e76dac36", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f76c3e11e2094a3db5ca89e4e76dac36.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f76c3e11e2094a3db5ca89e4e76dac36"}}, "title": "Heparin binding protein in severe COVID-19-A prospective observational cohort study.", "authors": [{"family": "Mellhammar", "given": "Lisa", "initials": "L"}, {"family": "Thelaus", "given": "Louise", "initials": "L"}, {"family": "El\u00e9n", "given": "Sixten", "initials": "S"}, {"family": "Fisher", "given": "Jane", "initials": "J"}, {"family": "Linder", "given": "Adam", "initials": "A"}], "type": "journal article", "published": "2021-04-06", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "4", "pages": "e0249570", "issn-l": "1932-6203"}, "abstract": "Neutrophil-derived heparin binding protein (HBP; also known as azurocidin or CAP-37) is a key player in bacterial sepsis and a promising biomarker in severe infections. The aims of this study were to assess whether HBP is involved in the pathophysiology of COVID-19 and, if so, whether it can be used to predict severe disease preferably using a point-of-care test.\n\nThis was a prospective convenience sample study of biomarkers in patients admitted to Sk\u00e5ne University hospital in Sweden with a confirmed COVID-19 diagnosis. Plasma samples and clinical data were collected within 72h after admission, during hospital stay and at discharge. Plasma HBP concentrations samples were measured both with enzyme-linked immunosorbent assay (ELISA) and with a novel dry immunofluorescence analyzer (Joinstar) point-of-care test.\n\nThirty-five COVID-19 patients were enrolled in the study. Twenty-nine patients had blood samples taken within 72h after admission. We compared the highest HBP value taken within 72h after admission in patients who eventually developed organ dysfunction (n = 23) compared to those who did not (n = 6), and found that HBP was significantly elevated in those who developed organ dysfunction (25.0 ng/mL (interquartile range (IQR) 16.6-48.5) vs 10.6 ng/mL (IQR 4.8-21.7 ng/mL), p = 0.03). Point-of-care test measurements correlated well with ELISA measurements (R = 0.83). HBP measured by the POC device predicted development of COVID-induced organ dysfunction with an AUC of 0.88 (95% confidence interval (CI) 0.70-1.0).\n\nHBP is elevated prior to onset of organ dysfunction in patients with severe COVID-19 using a newly developed point-of-care test and hence HBP could be used in a clinical setting as a prognostic marker in COVID-19.", "doi": "10.1371/journal.pone.0249570", "pmid": "33822821", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-37580"}], "notes": [], "created": "2021-04-07T10:07:36.447Z", "modified": "2021-04-07T10:12:19.156Z"}, {"entity": "publication", "iuid": "45fc1c11b1b34a8590421d35f7cab87a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/45fc1c11b1b34a8590421d35f7cab87a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/45fc1c11b1b34a8590421d35f7cab87a"}}, "title": "Face mask use during the Covid-19 pandemic - the significance of culture and the symbolic meaning of behaviour.", "authors": [{"family": "Timpka", "given": "Toomas", "initials": "T"}, {"family": "Nyce", "given": "James M", "initials": "JM"}], "type": "journal article", "published": "2021-04-06", "journal": {"title": "Ann Epidemiol", "issn": "1873-2585", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "During public emergencies, a door can open on the fundamental elements upon which a society's social order is built. The Covid-19 pandemic has opened such a door in societies worldwide. We outline in this commentary some of these social elements and how they may have influenced face mask use during the early stages of the pandemic. The purpose is to expand the perspective on mechanisms that are relevant to consider in pandemic response planning. Our look at these fundamental elements showed that latent aspects of the dominant culture and various symbolic meanings of behaviours can reduce adherence with public health recommendations if they are overlooked in the strategic health plans. We conclude that when policymakers decide non-pharmacological interventions during pandemics, they should take into account fundamental attitudes and beliefs that may influence population behaviour. This will require paying attention to variations in things like culture and symbolic meanings of behaviour.", "doi": "10.1016/j.annepidem.2021.03.012", "pmid": "33836290", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S1047-2797(21)00056-9"}], "notes": [], "created": "2021-04-12T16:12:11.271Z", "modified": "2022-11-23T09:01:18.488Z"}, {"entity": "publication", "iuid": "4cf20ca7e7dd4720962ed406c5e2c909", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4cf20ca7e7dd4720962ed406c5e2c909.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4cf20ca7e7dd4720962ed406c5e2c909"}}, "title": "In Silico Mining of Terpenes from Red-Sea Invertebrates for SARS-CoV-2 Main Protease (M pro) Inhibitors.", "authors": [{"family": "Ibrahim", "given": "Mahmoud A A", "initials": "MAA"}, {"family": "Abdelrahman", "given": "Alaa H M", "initials": "AHM"}, {"family": "Mohamed", "given": "Tarik A", "initials": "TA"}, {"family": "Atia", "given": "Mohamed A M", "initials": "MAM"}, {"family": "Al-Hammady", "given": "Montaser A M", "initials": "MAM"}, {"family": "Abdeljawaad", "given": "Khlood A A", "initials": "KAA"}, {"family": "Elkady", "given": "Eman M", "initials": "EM"}, {"family": "Moustafa", "given": "Mahmoud F", "initials": "MF"}, {"family": "Alrumaihi", "given": "Faris", "initials": "F"}, {"family": "Allemailem", "given": "Khaled S", "initials": "KS"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}, {"family": "Par\u00e9", "given": "Paul W", "initials": "PW"}, {"family": "Efferth", "given": "Thomas", "initials": "T"}, {"family": "Hegazy", "given": "Mohamed-Elamir F", "initials": "MF"}], "type": "journal article", "published": "2021-04-05", "journal": {"title": "Molecules", "issn": "1420-3049", "volume": "26", "issue": "7", "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for the COVID-19 pandemic, which generated more than 1.82 million deaths in 2020 alone, in addition to 83.8 million infections. Currently, there is no antiviral medication to treat COVID-19. In the search for drug leads, marine-derived metabolites are reported here as prospective SARS-CoV-2 inhibitors. Two hundred and twenty-seven terpene natural products isolated from the biodiverse Red-Sea ecosystem were screened for inhibitor activity against the SARS-CoV-2 main protease (M pro) using molecular docking and molecular dynamics (MD) simulations combined with molecular mechanics/generalized Born surface area binding energy calculations. On the basis of in silico analyses, six terpenes demonstrated high potency as Mpro inhibitors with \u0394Gbinding \u2264 -40.0 kcal/mol. The stability and binding affinity of the most potent metabolite, erylosides B, were compared to the human immunodeficiency virus protease inhibitor, lopinavir. Erylosides B showed greater binding affinity towards SARS-CoV-2 Mpro than lopinavir over 100 ns with \u0394Gbinding values of -51.9 vs. -33.6 kcal/mol, respectively. Protein-protein interactions indicate that erylosides B biochemical signaling shares gene components that mediate severe acute respiratory syndrome diseases, including the cytokine- and immune-signaling components BCL2L1, IL2, and PRKC. Pathway enrichment analysis and Boolean network modeling were performed towards a deep dissection and mining of the erylosides B target-function interactions. The current study identifies erylosides B as a promising anti-COVID-19 drug lead that warrants further in vitro and in vivo testing.", "doi": "10.3390/molecules26072082", "pmid": "33916461", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "molecules26072082"}, {"db": "pmc", "key": "PMC8038614"}, {"db": "NCBI", "key": "NC_045512.2", "description": "Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, complete genome"}], "notes": [], "created": "2021-05-04T16:27:49.783Z", "modified": "2021-11-18T09:05:18.572Z"}, {"entity": "publication", "iuid": "317a13989d5e43c78a5e660bf9a2adb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/317a13989d5e43c78a5e660bf9a2adb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/317a13989d5e43c78a5e660bf9a2adb1"}}, "title": "Implementation of the COVID-19 Vulnerability Index Across an International Network of Health Care Data Sets: Collaborative External Validation Study.", "authors": [{"family": "Reps", "given": "Jenna M", "initials": "JM", "orcid": "0000-0002-2970-0778", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/135caa88779346ac97e682edad7b6805.json"}}, {"family": "Kim", "given": "Chungsoo", "initials": "C", "orcid": "0000-0003-1802-1777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19d957a32f3a4830b7e5937eb17ab595.json"}}, {"family": "Williams", "given": "Ross D", "initials": "RD", "orcid": "0000-0001-7723-417X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0392fa0097654386b5afb53621736a2b.json"}}, {"family": "Markus", "given": "Aniek F", "initials": "AF", "orcid": "0000-0001-5779-4794", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9266586bbfd54362bd837362d99e6f98.json"}}, {"family": "Yang", "given": "Cynthia", "initials": "C", "orcid": "0000-0001-6769-3153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1492941467c846b8a87f70a8f007de80.json"}}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T", "orcid": "0000-0002-8274-0357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11fd8deb257445e7a93a0a3098b246df.json"}}, {"family": "Falconer", "given": "Thomas", "initials": "T", "orcid": "0000-0001-6904-1394", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39f9b217653b4b3d8ad2b4ce30d1ca80.json"}}, {"family": "Jonnagaddala", "given": "Jitendra", "initials": "J", "orcid": "0000-0002-9912-2344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8403290b9ec43fe93b558de97d84559.json"}}, {"family": "Williams", "given": "Andrew", "initials": "A", "orcid": "0000-0002-0692-412X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/287d6018570d44588277109d7fb7e705.json"}}, {"family": "Fern\u00e1ndez-Bertol\u00edn", "given": "Sergio", "initials": "S", "orcid": "0000-0002-0029-6564", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d21eaa376144a42be9422fb45441fb4.json"}}, {"family": "DuVall", "given": "Scott L", "initials": "SL", "orcid": "0000-0002-4898-3865", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd524264c46548cf861123d43d57151a.json"}}, {"family": "Kostka", "given": "Kristin", "initials": "K", "orcid": "0000-0003-2595-8736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9675cf1b775341f6a3521c7dde950262.json"}}, {"family": "Rao", "given": "Gowtham", "initials": "G", "orcid": "0000-0002-4949-7236", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2ed658710d4a5eb53b4b0da495b6b4.json"}}, {"family": "Shoaibi", "given": "Azza", "initials": "A", "orcid": "0000-0002-6976-2594", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58deef993a4e4e008923f454d8617b61.json"}}, {"family": "Ostropolets", "given": "Anna", "initials": "A", "orcid": "0000-0002-0847-6682", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f642e577d2445a3a7ce873b42d0c479.json"}}, {"family": "Spotnitz", "given": "Matthew E", "initials": "ME", "orcid": "0000-0003-2869-0237", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d85f7c654b554b66b57eea3c47b33468.json"}}, {"family": "Zhang", "given": "Lin", "initials": "L", "orcid": "0000-0002-2064-8440", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b787b06f236743559ac8b09000d66ace.json"}}, {"family": "Casajust", "given": "Paula", "initials": "P", "orcid": "0000-0003-2733-5436", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8a3feb959bd461c8c4ad81fcd9dee8b.json"}}, {"family": "Steyerberg", "given": "Ewout W", "initials": "EW", "orcid": "0000-0002-7787-0122", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f248f68b4e144348a1969407863dadb8.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Kaas-Hansen", "given": "Benjamin Skov", "initials": "BS", "orcid": "0000-0003-1023-0371", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2365fe9468204435b0bb04abc7edface.json"}}, {"family": "Choi", "given": "Young Hwa", "initials": "YH", "orcid": "0000-0001-5254-3101", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e99fc02a7e45f197e6d745bb214e9c.json"}}, {"family": "Morales", "given": "Daniel", "initials": "D", "orcid": "0000-0002-0063-8069", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2db57e8786f41168f4a59dcab7086c3.json"}}, {"family": "Liaw", "given": "Siaw-Teng", "initials": "ST", "orcid": "0000-0001-5989-3614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aacd21dc33904474aa9239d5da644a84.json"}}, {"family": "Abrah\u00e3o", "given": "Maria Tereza Fernandes", "initials": "MTF", "orcid": "0000-0003-2701-670X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/725376c88fe14c138abace2cb37170b4.json"}}, {"family": "Areia", "given": "Carlos", "initials": "C", "orcid": "0000-0002-4668-7069", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7232f54be5df43f0b984d0117d88a054.json"}}, {"family": "Matheny", "given": "Michael E", "initials": "ME", "orcid": "0000-0003-3217-4147", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75cbaa15413a4673ae9037f58cc9a314.json"}}, {"family": "Lynch", "given": "Kristine E", "initials": "KE", "orcid": "0000-0002-2221-2421", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fdab158b00984381b1379ab876c1e09f.json"}}, {"family": "Arag\u00f3n", "given": "Mar\u00eda", "initials": "M", "orcid": "0000-0002-5990-6953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7030a55a3e84c36ad06f405dc1f9d68.json"}}, {"family": "Park", "given": "Rae Woong", "initials": "RW", "orcid": "0000-0003-4989-3287", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8974a9e22f940d7939f0bec7810c9c6.json"}}, {"family": "Hripcsak", "given": "George", "initials": "G", "orcid": "0000-0003-2664-7614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93e21b1266964d22b49cdafdd03caa7d.json"}}, {"family": "Reich", "given": "Christian G", "initials": "CG", "orcid": "0000-0002-3641-055X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6982fa4f228643c6bac91609a0b336d3.json"}}, {"family": "Suchard", "given": "Marc A", "initials": "MA", "orcid": "0000-0001-9818-479X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f920e0e55c94e91b4dcff796bd24246.json"}}, {"family": "You", "given": "Seng Chan", "initials": "SC", "orcid": "0000-0002-5052-6399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4be7ad3cc7c6440b9f628d7bcedc8a6a.json"}}, {"family": "Ryan", "given": "Patrick B", "initials": "PB", "orcid": "0000-0002-9727-2138", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7f5f6d8b6bb4d85b1430cda6aea55b8.json"}}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D", "orcid": "0000-0002-3950-6346", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1c3f99e11244a3b90ba881356d3e259.json"}}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR", "orcid": "0000-0003-0621-1979", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d03ea51cfd6344d5a6469fef31e9f941.json"}}], "type": "journal article", "published": "2021-04-05", "journal": {"title": "JMIR Med Inform", "issn": "2291-9694", "issn-l": null, "volume": "9", "issue": "4", "pages": "e21547"}, "abstract": "SARS-CoV-2 is straining health care systems globally. The burden on hospitals during the pandemic could be reduced by implementing prediction models that can discriminate patients who require hospitalization from those who do not. The COVID-19 vulnerability (C-19) index, a model that predicts which patients will be admitted to hospital for treatment of pneumonia or pneumonia proxies, has been developed and proposed as a valuable tool for decision-making during the pandemic. However, the model is at high risk of bias according to the \"prediction model risk of bias assessment\" criteria, and it has not been externally validated.\n\nThe aim of this study was to externally validate the C-19 index across a range of health care settings to determine how well it broadly predicts hospitalization due to pneumonia in COVID-19 cases.\n\nWe followed the Observational Health Data Sciences and Informatics (OHDSI) framework for external validation to assess the reliability of the C-19 index. We evaluated the model on two different target populations, 41,381 patients who presented with SARS-CoV-2 at an outpatient or emergency department visit and 9,429,285 patients who presented with influenza or related symptoms during an outpatient or emergency department visit, to predict their risk of hospitalization with pneumonia during the following 0-30 days. In total, we validated the model across a network of 14 databases spanning the United States, Europe, Australia, and Asia.\n\nThe internal validation performance of the C-19 index had a C statistic of 0.73, and the calibration was not reported by the authors. When we externally validated it by transporting it to SARS-CoV-2 data, the model obtained C statistics of 0.36, 0.53 (0.473-0.584) and 0.56 (0.488-0.636) on Spanish, US, and South Korean data sets, respectively. The calibration was poor, with the model underestimating risk. When validated on 12 data sets containing influenza patients across the OHDSI network, the C statistics ranged between 0.40 and 0.68.\n\nOur results show that the discriminative performance of the C-19 index model is low for influenza cohorts and even worse among patients with COVID-19 in the United States, Spain, and South Korea. These results suggest that C-19 should not be used to aid decision-making during the COVID-19 pandemic. Our findings highlight the importance of performing external validation across a range of settings, especially when a prediction model is being extrapolated to a different population. In the field of prediction, extensive validation is required to create appropriate trust in a model.", "doi": "10.2196/21547", "pmid": "33661754", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8023380"}, {"db": "pii", "key": "v9i4e21547"}], "notes": [], "created": "2021-11-15T06:53:48.925Z", "modified": "2023-06-19T15:02:21.240Z"}, {"entity": "publication", "iuid": "42c6f5159867443ba26ed8b54fdc4294", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/42c6f5159867443ba26ed8b54fdc4294.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/42c6f5159867443ba26ed8b54fdc4294"}}, "title": "Driving potent neutralization of a SARS-CoV-2 Variant of Concern with a heterotypic boost", "authors": [{"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Mandolesi", "given": "Marco", "initials": "M"}, {"family": "Kim", "given": "Changil", "initials": "C"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Vidakovics", "given": "Laura Perez", "initials": "LP"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Hedestam", "given": "Gunilla B Karlsson", "initials": "GBK"}, {"family": "Murrell", "given": "Ben", "initials": "B"}], "type": "posted-content", "published": "2021-04-05", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.03.438330", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Funder: H2020": null, "Funder: VR": null}, "xrefs": [{"db": "URL", "key": "https://github.com/MurrellGroup/VOCfreq", "description": "code to complete analyses and instructions to acquire data"}], "notes": [], "created": "2021-04-08T18:37:21.184Z", "modified": "2021-11-18T11:58:02.091Z"}, {"entity": "publication", "iuid": "513b358e6a614996b03261079249c2d6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/513b358e6a614996b03261079249c2d6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/513b358e6a614996b03261079249c2d6"}}, "title": "COVID-19 vaccination in mastocytosis: recommendations of the European Competence Network on Mastocytosis (ECNM) and American Initiative in Mast Cell Diseases (AIM).", "authors": [{"family": "Bonadonna", "given": "Patrizia", "initials": "P"}, {"family": "Brockow", "given": "Knut", "initials": "K"}, {"family": "Niedoszytko", "given": "Marek", "initials": "M"}, {"family": "Elberink", "given": "Hanneke Oude", "initials": "HO"}, {"family": "Akin", "given": "Cem", "initials": "C"}, {"family": "Nedoszytko", "given": "Boguslaw", "initials": "B"}, {"family": "Butterfield", "given": "Joseph H", "initials": "JH"}, {"family": "Alvarez-Twose", "given": "Ivan", "initials": "I"}, {"family": "Sotlar", "given": "Karl", "initials": "K"}, {"family": "Schwaab", "given": "Juliana", "initials": "J"}, {"family": "Jawhar", "given": "Mohamad", "initials": "M"}, {"family": "Castells", "given": "Mariana", "initials": "M"}, {"family": "Sperr", "given": "Wolfgang R", "initials": "WR"}, {"family": "Hermine", "given": "Olivier", "initials": "O"}, {"family": "Gotlib", "given": "Jason", "initials": "J"}, {"family": "Zanotti", "given": "Roberta", "initials": "R"}, {"family": "Reiter", "given": "Andreas", "initials": "A"}, {"family": "Broesby-Olsen", "given": "Sigurd", "initials": "S"}, {"family": "Bindslev-Jensen", "given": "Carsten", "initials": "C"}, {"family": "Schwartz", "given": "Lawrence B", "initials": "LB"}, {"family": "Horny", "given": "Hans-Peter", "initials": "HP"}, {"family": "Radia", "given": "Deepti", "initials": "D"}, {"family": "Triggiani", "given": "Massimo", "initials": "M"}, {"family": "Sabato", "given": "Vito", "initials": "V"}, {"family": "Carter", "given": "Melody C", "initials": "MC"}, {"family": "Siebenhaar", "given": "Frank", "initials": "F"}, {"family": "Orfao", "given": "Alberto", "initials": "A"}, {"family": "Grattan", "given": "Clive", "initials": "C"}, {"family": "Metcalfe", "given": "Dean D", "initials": "DD"}, {"family": "Arock", "given": "Michel", "initials": "M"}, {"family": "Gulen", "given": "Theo", "initials": "T"}, {"family": "Hartmann", "given": "Karin", "initials": "K"}, {"family": "Valent", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2021-04-05", "journal": {"title": "J Allergy Clin Immunol Pract", "issn": "2213-2201", "volume": null, "issue": null, "issn-l": null}, "abstract": "Mastocytosis is a neoplasm characterized by an accumulation of mast cells in various organs and increased risk for severe anaphylaxis in patients with concomitant allergies. Covid-19 is a pandemic that is associated with a relatively high rate of severe lung disease and mortality. The mortality is particularly high in those with certain comorbidities and increases with age. Recently, several companies have developed an effective vaccination against Covid-19. Although the reported frequency of severe side effects is low, there is an emerging discussion about the safety of Covid-19 vaccination in patients with severe allergies and mastocytosis. However, even in these patients, severe adverse reactions are rare. We therefore recommend the broad use of Covid-19 vaccination in patients with mastocytosis on a global basis. The only well-established exception is a known or suspected allergy against a constituent of the vaccine. Safety measures, including premedication and post-vaccination observation should be considered in all patients with mastocytosis, depending on the individual personal risk and overall situation in each case. The current article provides a summary of published data, observations and expert opinion that form the basis of these recommendations.", "doi": "10.1016/j.jaip.2021.03.041", "pmid": "33831618", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2213-2198(21)00386-X"}], "notes": [], "created": "2021-04-09T16:46:32.560Z", "modified": "2021-04-23T16:05:54.583Z"}, {"entity": "publication", "iuid": "cec71ba523f3439d9f438153be347ae4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cec71ba523f3439d9f438153be347ae4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cec71ba523f3439d9f438153be347ae4"}}, "title": "COVID-19 research priorities for non-pharmaceutical public health and social measures.", "authors": [{"family": "Semenza", "given": "Jan C", "initials": "JC"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Baka", "given": "Agoritsa", "initials": "A"}, {"family": "Broberg", "given": "Eeva", "initials": "E"}, {"family": "Cenciarelli", "given": "Orlando", "initials": "O"}, {"family": "De Angelis", "given": "Stefania", "initials": "S"}, {"family": "Einoder-Moreno", "given": "Margot", "initials": "M"}, {"family": "Dalmau", "given": "Irina Jovel Quinonez", "initials": "IJQ"}, {"family": "Kinross", "given": "Pete", "initials": "P"}, {"family": "Kinsman", "given": "John", "initials": "J"}, {"family": "Leitmeyer", "given": "Katrin", "initials": "K"}, {"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "Needham", "given": "Howard", "initials": "H"}, {"family": "Plachouras", "given": "Diamantis", "initials": "D"}, {"family": "Robesyn", "given": "Emmanuel", "initials": "E"}, {"family": "Rosales-Klintz", "given": "Senia", "initials": "S"}, {"family": "Suk", "given": "Jonathan E", "initials": "JE"}, {"family": "Suetens", "given": "Carl", "initials": "C"}, {"family": "Weist", "given": "Klaus", "initials": "K"}, {"family": "W\u00fcrz", "given": "Andrea", "initials": "A"}, {"family": "Penttinen", "given": "Pasi", "initials": "P"}], "type": "journal article", "published": "2021-04-05", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": null, "issue": null, "pages": "1-12", "issn-l": null}, "abstract": null, "doi": "10.1017/S0950268821000716", "pmid": "33818348", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0950268821000716"}], "notes": [], "created": "2021-04-06T10:04:18.839Z", "modified": "2021-04-06T10:04:18.848Z"}, {"entity": "publication", "iuid": "3c9d39c1019b430086cd725b0aff2ad5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3c9d39c1019b430086cd725b0aff2ad5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3c9d39c1019b430086cd725b0aff2ad5"}}, "title": "COVID-19: A novel burden on the fragile health system of Angola.", "authors": [{"family": "Gyeltshen", "given": "Dawa", "initials": "D"}, {"family": "Musa", "given": "Shuaibu Saidu", "initials": "SS"}, {"family": "Amesho", "given": "Josephine Ndapewoshali", "initials": "JN"}, {"family": "Ewelike", "given": "Samuel Chukwuebuka", "initials": "SC"}, {"family": "Bayoh", "given": "Alex Vandy Saffa", "initials": "AVS"}, {"family": "Al-Sammour", "given": "Christophe", "initials": "C"}, {"family": "Camua", "given": "Angel Anthony", "initials": "AA"}, {"family": "Lin", "given": "Xu", "initials": "X"}, {"family": "Lowe", "given": "Mat", "initials": "M"}, {"family": "Ahmadi", "given": "Attaullah", "initials": "A"}, {"family": "Ntacyabukura", "given": "Blaise", "initials": "B"}, {"family": "Adebisi", "given": "Yusuff Adebayo", "initials": "YA"}, {"family": "Lucero-Prisno", "given": "Don Eliseo", "initials": "DE"}], "type": "journal article", "published": "2021-04-03", "journal": {"title": "J Glob Health", "issn": "2047-2986", "volume": "11", "issue": null, "pages": "03059", "issn-l": "2047-2978"}, "abstract": null, "doi": "10.7189/jogh.11.03059", "pmid": "33828839", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jogh-11-03059"}, {"db": "pmc", "key": "PMC8021071"}], "notes": [], "created": "2021-04-09T16:43:53.499Z", "modified": "2021-04-09T16:44:17.395Z"}, {"entity": "publication", "iuid": "d8ee3c70a18b4950b58b8cc0d0a44279", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d8ee3c70a18b4950b58b8cc0d0a44279.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d8ee3c70a18b4950b58b8cc0d0a44279"}}, "title": "COVID-19 in solid organ transplant recipients: A national cohort study from Sweden.", "authors": [{"family": "S\u00f8fteland", "given": "John Mackay", "initials": "JM"}, {"family": "Friman", "given": "Gustav", "initials": "G"}, {"family": "von Zur-M\u00fchlen", "given": "Bengt", "initials": "B"}, {"family": "Ericzon", "given": "Bo-G\u00f6ran", "initials": "B"}, {"family": "Wallquist", "given": "Carin", "initials": "C"}, {"family": "Karason", "given": "Kristjan", "initials": "K"}, {"family": "Friman", "given": "Vanda", "initials": "V"}, {"family": "Ekelund", "given": "Jan", "initials": "J"}, {"family": "Felldin", "given": "Marie", "initials": "M"}, {"family": "Magnusson", "given": "Jesper", "initials": "J"}, {"family": "Haugen L\u00f6fman", "given": "Ida", "initials": "I"}, {"family": "Schult", "given": "Andreas", "initials": "A"}, {"family": "de Coursey", "given": "Emily", "initials": "E"}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Jacobsson", "given": "Hanna", "initials": "H"}, {"family": "Liljeqvist", "given": "Jan-\u00c5ke", "initials": "J"}, {"family": "Biglarnia", "given": "Ali Reza", "initials": "AR"}, {"family": "Lindn\u00e9r", "given": "Per", "initials": "P"}, {"family": "Oltean", "given": "Mihai", "initials": "M"}], "type": "journal article", "published": "2021-04-03", "journal": {"title": "Am J Transplant", "issn": "1600-6143", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Solid organ transplant (SOT) recipients run a high risk for adverse outcomes from COVID-19, with reported mortality around 19%. We retrospectively reviewed all known Swedish SOT recipients with RT-PCR confirmed COVID-19 between March 1 st and November 20th, 2020 and analyzed patient characteristics, management, and outcome. We identified 230 patients with a median age of 54.0 years (13.2), who were predominantly male (64%). Most patients were hospitalized (64%), but 36% remained outpatients. Age >50 and male sex were among predictors of transition from outpatient to inpatient status. National early warning Score 2 (NEWS2) at presentation was higher in non-survivors. Thirty-day all-cause mortality was 9.6% (15.0% for inpatients), increased with age and BMI, and was higher in men. Renal function decreased during COVID-19 but recovered in most patients. SARS-CoV-2 antibodies were identified in 78% of patients at 1-2 months post-infection. Nucleocapsid-specific antibodies decreased to 38% after 6-7 months, while spike-specific antibody responses were more durable. Seroprevalence in 559 asymptomatic patients was 1.4%. Many patients can be managed on an outpatient basis aided by risk stratification with age, sex, and NEWS2 score. Factors associated with adverse outcomes include older age, male sex, greater BMI, and a higher NEWS2 score.", "doi": "10.1111/ajt.16596", "pmid": "33811777", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-06T10:13:30.721Z", "modified": "2021-04-06T10:13:53.666Z"}, {"entity": "publication", "iuid": "e2b438d13f5e46f5bf03be41bc5f6b15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2b438d13f5e46f5bf03be41bc5f6b15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2b438d13f5e46f5bf03be41bc5f6b15"}}, "title": "A mediating role for mental health in associations between COVID-19-related self-stigma, PTSD, quality of life, and insomnia among patients recovered from COVID-19.", "authors": [{"family": "Mahmoudi", "given": "Hosein", "initials": "H"}, {"family": "Saffari", "given": "Mohsen", "initials": "M"}, {"family": "Movahedi", "given": "Mahmoud", "initials": "M"}, {"family": "Sanaeinasab", "given": "Hormoz", "initials": "H"}, {"family": "Rashidi-Jahan", "given": "Hojat", "initials": "H"}, {"family": "Pourgholami", "given": "Morteza", "initials": "M"}, {"family": "Poorebrahim", "given": "Ali", "initials": "A"}, {"family": "Barshan", "given": "Jalal", "initials": "J"}, {"family": "Ghiami", "given": "Milad", "initials": "M"}, {"family": "Khoshmanesh", "given": "Saman", "initials": "S"}, {"family": "Potenza", "given": "Marc N", "initials": "MN"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-04-03", "journal": {"title": "Brain Behav", "issn": "2162-3279", "issn-l": null, "volume": null, "issue": null, "pages": "e02138"}, "abstract": "Patients with COVID-19 often suffer from psychological problems such as post-traumatic stress disorder (PTSD) and self-stigmatization that may negatively impact their quality of life and sleep. This study examined mental health as a potential mediating factor linking self-stigmatization and PTSD to quality of life and sleep.\r\n\r\nUsing a cross-sectional design, 844 people who had recovered from COVID-19 were called and interviewed. Data were collected using structured scales. Structural equation modeling was applied to assess fitness of a mediation model including self-stigma and PTSD as independent factors and quality of life and insomnia as dependent variables.\r\n\r\nMental health, COVID-19-related self-stigma, and mental quality of life were associated. Insomnia, PTSD, and COVID-19-related self-stigma displayed significant direct associations (r = .334 to 0.454; p < .01). A mediation model indicated satisfactory goodness of fit (CFI = 0.968, TLI = 0.950, SRMR = 0.071, RMSEA = 0.068). Mental health as a mediator had negative relationships with COVID-19-related self-stigma, PTSD, and insomnia and positive associations with quality of life.\r\n\r\nMental health may mediate effects of COVID-19-related self-stigma and PTSD on quality of life and insomnia. Designing programs to improve mental health among patients with COVID-19 may include efforts to reduce negative effects of PTSD and COVID-19-related self-stigma on quality of life and insomnia.", "doi": "10.1002/brb3.2138", "pmid": "33811451", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-04-06T10:14:42.317Z", "modified": "2021-06-18T15:50:55.477Z"}, {"entity": "publication", "iuid": "38fb2ecbee504f5b8f2376f0b9fee004", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38fb2ecbee504f5b8f2376f0b9fee004.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38fb2ecbee504f5b8f2376f0b9fee004"}}, "title": "Vaccines and Allergic reactions: the past, the current COVID-19 pandemic, and future perspectives.", "authors": [{"family": "Sampath", "given": "Vanitha", "initials": "V"}, {"family": "Rabinowitz", "given": "Grace", "initials": "G"}, {"family": "Shah", "given": "Mihir", "initials": "M"}, {"family": "Jain", "given": "Surabhi", "initials": "S"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}, {"family": "Jesenak", "given": "Milos", "initials": "M"}, {"family": "Rabin", "given": "Ronald", "initials": "R"}, {"family": "Vieths", "given": "Stefan", "initials": "S"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Akdis", "given": "M\u00fcbeccel", "initials": "M"}, {"family": "Barber", "given": "Domingo", "initials": "D"}, {"family": "Breiteneder", "given": "Heimo", "initials": "H"}, {"family": "Chinthrajah", "given": "Sharon", "initials": "S"}, {"family": "Chivato", "given": "Tomas", "initials": "T"}, {"family": "Collins", "given": "William", "initials": "W"}, {"family": "Eiwegger", "given": "Thomas", "initials": "T"}, {"family": "Fast", "given": "Katherine", "initials": "K"}, {"family": "Fokkens", "given": "Wytske", "initials": "W"}, {"family": "O'Hehir", "given": "Robyn E", "initials": "RE"}, {"family": "Ollert", "given": "Markus", "initials": "M"}, {"family": "O'Mahony", "given": "Liam", "initials": "L"}, {"family": "Palomares", "given": "Oscar", "initials": "O"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Riggioni", "given": "Carmen", "initials": "C"}, {"family": "Shamji", "given": "Mohamed H", "initials": "MH"}, {"family": "Sokolowska", "given": "Milena", "initials": "M"}, {"family": "Torres", "given": "Maria Jose", "initials": "MJ"}, {"family": "Traidl-Hoffmann", "given": "Claudia", "initials": "C"}, {"family": "van Zelm", "given": "Menno", "initials": "M"}, {"family": "Wang", "given": "De Yun", "initials": "Y"}, {"family": "Zhang", "given": "Luo", "initials": "L"}, {"family": "Akdis", "given": "CezmiA", "initials": "C"}, {"family": "Nadeau", "given": "Kari C", "initials": "KC"}], "type": "journal article", "published": "2021-04-02", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": null, "issue": null, "issn-l": "0105-4538"}, "abstract": "Vaccines are essential public health tools with a favorable safety profile and prophylactic effectiveness that have historically played significant roles in reducing infectious disease burden in populations, when the majority of individuals are vaccinated. The COVID-19 vaccines are expected to have similar positive impacts on health across the globe. While serious allergic reactions to vaccines are rare, their underlying mechanisms and implications for clinical management should be considered to provide individuals with the safest care possible. In this review, we provide an overview of different types of allergic adverse reactions that can potentially occur aftervaccination and individual vaccine components capable of causing the allergic adverse reactions. We present the incidence of allergic adverse reactions during clinical studies and through post-authorization and post-marketing surveillance and provide plausible causes of these reactions based on potential allergenic components present in several common vaccines. Additionally, we review implications for individual diagnosis and management and vaccine manufacturing overall. Finally, we suggest areas for future research.", "doi": "10.1111/all.14840", "pmid": "33811364", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-04-06T10:17:59.817Z", "modified": "2021-04-23T16:06:21.995Z"}, {"entity": "publication", "iuid": "e24ad035f5844436a6bb40be8e35a395", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e24ad035f5844436a6bb40be8e35a395.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e24ad035f5844436a6bb40be8e35a395"}}, "title": "Stealth Fluorescence Labeling for Live Microscopy Imaging of mRNA Delivery.", "authors": [{"family": "Baladi", "given": "Tom", "initials": "T"}, {"family": "Nilsson", "given": "Jesper R", "initials": "JR"}, {"family": "Gallud", "given": "Audrey", "initials": "A"}, {"family": "Celauro", "given": "Emanuele", "initials": "E"}, {"family": "Gasse", "given": "C\u00e9cile", "initials": "C"}, {"family": "Levi-Acobas", "given": "Fabienne", "initials": "F"}, {"family": "Sarac", "given": "Ivo", "initials": "I"}, {"family": "Hollenstein", "given": "Marcel R", "initials": "MR"}, {"family": "Dahl\u00e9n", "given": "Anders", "initials": "A"}, {"family": "Esbj\u00f6rner", "given": "Elin K", "initials": "EK"}, {"family": "Wilhelmsson", "given": "L Marcus", "initials": "LM"}], "type": "journal article", "published": "2021-04-02", "journal": {"title": "J Am Chem Soc", "issn": "1520-5126", "volume": null, "issue": null, "issn-l": null}, "abstract": "Methods for tracking RNA inside living cells without perturbing their natural interactions and functions are critical within biology and, in particular, to facilitate studies of therapeutic RNA delivery. We present a stealth labeling approach that can efficiently, and with high fidelity, generate RNA transcripts, through enzymatic incorporation of the triphosphate of tC O, a fluorescent tricyclic cytosine analogue. We demonstrate this by incorporation of tCO in up to 100% of the natural cytosine positions of a 1.2 kb mRNA encoding for the histone H2B fused to GFP (H2B:GFP). Spectroscopic characterization of this mRNA shows that the incorporation rate of tCO is similar to cytosine, which allows for efficient labeling and controlled tuning of labeling ratios for different applications. Using live cell confocal microscopy and flow cytometry, we show that the tCO-labeled mRNA is efficiently translated into H2B:GFP inside human cells. Hence, we not only develop the use of fluorescent base analogue labeling of nucleic acids in live-cell microscopy but also, importantly, show that the resulting transcript is translated into the correct protein. Moreover, the spectral properties of our transcripts and their translation product allow for their straightforward, simultaneous visualization in live cells. Finally, we find that chemically transfected tCO-labeled RNA, unlike a state-of-the-art fluorescently labeled RNA, gives rise to expression of a similar amount of protein as its natural counterpart, hence representing a methodology for studying natural, unperturbed processing of mRNA used in RNA therapeutics and in vaccines, like the ones developed against SARS-CoV-2.", "doi": "10.1021/jacs.1c00014", "pmid": "33797236", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-06T10:41:47.769Z", "modified": "2021-04-06T10:41:47.794Z"}, {"entity": "publication", "iuid": "cda6c30f70f24141b31a4e3611da36b6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cda6c30f70f24141b31a4e3611da36b6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cda6c30f70f24141b31a4e3611da36b6"}}, "title": "Management of anaphylaxis due to COVID-19 vaccines in the elderly.", "authors": [{"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Blain", "given": "Hubert", "initials": "H"}, {"family": "Jutel", "given": "Marek", "initials": "M"}, {"family": "Ventura", "given": "Maria Teresa", "initials": "MT"}, {"family": "Worm", "given": "Margitta", "initials": "M"}, {"family": "Del Giacco", "given": "Stefano", "initials": "S"}, {"family": "Benetos", "given": "Athanasios", "initials": "A"}, {"family": "Bilo", "given": "M Beatrice", "initials": "MB"}, {"family": "Czarlewski", "given": "Wienczyslawa", "initials": "W"}, {"family": "Abdul Latiff", "given": "Amir Hamzah", "initials": "AH"}, {"family": "Al-Ahmad", "given": "Mona", "initials": "M"}, {"family": "Angier", "given": "Elizabeth", "initials": "E"}, {"family": "Annesi-Maesano", "given": "Isabella", "initials": "I"}, {"family": "Atanaskovic-Markovic", "given": "Marina", "initials": "M"}, {"family": "Bachert", "given": "Claus", "initials": "C"}, {"family": "Barbaud", "given": "Annick", "initials": "A"}, {"family": "Bedbrook", "given": "Anna", "initials": "A"}, {"family": "Bennoor", "given": "Kazi S", "initials": "KS"}, {"family": "Berghea", "given": "Elena Camelia", "initials": "EC"}, {"family": "Bindslev-Jensen", "given": "Carsten", "initials": "C"}, {"family": "Bonini", "given": "Sergio", "initials": "S"}, {"family": "Bosnic-Anticevich", "given": "Sinthia", "initials": "S"}, {"family": "Brockow", "given": "Knut", "initials": "K"}, {"family": "Brussino", "given": "Luisa", "initials": "L"}, {"family": "Camargos", "given": "Paulo", "initials": "P"}, {"family": "Canonica", "given": "G Walter", "initials": "GW"}, {"family": "Cardona", "given": "Victoria", "initials": "V"}, {"family": "Carreiro-Martins", "given": "Pedro", "initials": "P"}, {"family": "Carriazo", "given": "Ana", "initials": "A"}, {"family": "Casale", "given": "Thomas", "initials": "T"}, {"family": "Caubet", "given": "Jean-Christoph", "initials": "JC"}, {"family": "Cecchi", "given": "Lorenzo", "initials": "L"}, {"family": "Cherubini", "given": "Antonio", "initials": "A"}, {"family": "Christoff", "given": "George", "initials": "G"}, {"family": "Chu", "given": "Derek K", "initials": "DK"}, {"family": "Cruz", "given": "Alvaro A", "initials": "AA"}, {"family": "Dokic", "given": "Dejan", "initials": "D"}, {"family": "El-Gamal", "given": "Yehia", "initials": "Y"}, {"family": "Ebisawa", "given": "Motohiro", "initials": "M"}, {"family": "Eberlein", "given": "Bernadette", "initials": "B"}, {"family": "Farrell", "given": "John", "initials": "J"}, {"family": "Fernandez-Rivas", "given": "Montserrat", "initials": "M"}, {"family": "Fokkens", "given": "Wytske J", "initials": "WJ"}, {"family": "Fonseca", "given": "Joao A", "initials": "JA"}, {"family": "Gao", "given": "Yadong", "initials": "Y"}, {"family": "Gavazzi", "given": "Ga\u00ebtan", "initials": "G"}, {"family": "Gawlik", "given": "Radolslaw", "initials": "R"}, {"family": "Gelincik", "given": "Asli", "initials": "A"}, {"family": "Gemicio\u011flu", "given": "Bilun", "initials": "B"}, {"family": "Gotua", "given": "Maia", "initials": "M"}, {"family": "Gu\u00e9rin", "given": "Olivier", "initials": "O"}, {"family": "Haahtela", "given": "Tari", "initials": "T"}, {"family": "Hoffmann-Sommergruber", "given": "Karin", "initials": "K"}, {"family": "Hoffmann", "given": "Hans J\u00fcrgen", "initials": "HJ"}, {"family": "Hofmann", "given": "Maja", "initials": "M"}, {"family": "Hrubisko", "given": "Martin", "initials": "M"}, {"family": "lenaIllario", "given": "Madda", "initials": "M"}, {"family": "Irani", "given": "Carla", "initials": "C"}, {"family": "Ispayeva", "given": "Zhanat", "initials": "Z"}, {"family": "Ivancevich", "given": "Juan Carlos", "initials": "JC"}, {"family": "Julge", "given": "Kaja", "initials": "K"}, {"family": "Kaidashev", "given": "Igor", "initials": "I"}, {"family": "Khaitov", "given": "Musa", "initials": "M"}, {"family": "Knol", "given": "Edward", "initials": "E"}, {"family": "Kraxner", "given": "Helga", "initials": "H"}, {"family": "Kuna", "given": "Piotr", "initials": "P"}, {"family": "Kvedariene", "given": "Violeta", "initials": "V"}, {"family": "Lauerma", "given": "Antti", "initials": "A"}, {"family": "Le", "given": "Lan Tt", "initials": "LT"}, {"family": "Le Moing", "given": "Vincent", "initials": "V"}, {"family": "Levin", "given": "Michael", "initials": "M"}, {"family": "Louis", "given": "Renaud", "initials": "R"}, {"family": "Lourenco", "given": "Olga", "initials": "O"}, {"family": "Mahler", "given": "Vera", "initials": "V"}, {"family": "Martin", "given": "Finbarr C", "initials": "FC"}, {"family": "Matucci", "given": "Andrea", "initials": "A"}, {"family": "Milenkovic", "given": "Branislava", "initials": "B"}, {"family": "Miot", "given": "St\u00e9phanie", "initials": "S"}, {"family": "Montella", "given": "Emma", "initials": "E"}, {"family": "Morais-Almeida", "given": "Mario", "initials": "M"}, {"family": "Mortz", "given": "Charlotte G", "initials": "CG"}, {"family": "Mullol", "given": "Joaquim", "initials": "J"}, {"family": "Namazova-Baranova", "given": "Leyla", "initials": "L"}, {"family": "Neffen", "given": "Hugo", "initials": "H"}, {"family": "Nekam", "given": "Kristof", "initials": "K"}, {"family": "Niedoszytko", "given": "Marek", "initials": "M"}, {"family": "Odemyr", "given": "Mika\u00ebla", "initials": "M"}, {"family": "O'Hehir", "given": "Robyn E", "initials": "RE"}, {"family": "Okamoto", "given": "Yoshitaka", "initials": "Y"}, {"family": "Ollert", "given": "Markus", "initials": "M"}, {"family": "Palomares", "given": "Oscar", "initials": "O"}, {"family": "Papadopoulos", "given": "Nikolaos G", "initials": "NG"}, {"family": "Panzner", "given": "Petr", "initials": "P"}, {"family": "Passalacqua", "given": "Gianni", "initials": "G"}, {"family": "Patella", "given": "Vincenzo", "initials": "V"}, {"family": "Petrovic", "given": "Mirko", "initials": "M"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Pham-Thi", "given": "Nh\u00e2n", "initials": "N"}, {"family": "Plavec", "given": "Davor", "initials": "D"}, {"family": "Popov", "given": "Todor A", "initials": "TA"}, {"family": "Recto", "given": "Marysia T", "initials": "MT"}, {"family": "Regateiro", "given": "Frederico S", "initials": "FS"}, {"family": "Reynes", "given": "Jacques", "initials": "J"}, {"family": "Roller-Winsberger", "given": "Regina E", "initials": "RE"}, {"family": "Rolland", "given": "Yves", "initials": "Y"}, {"family": "Romano", "given": "Antonino", "initials": "A"}, {"family": "Rondon", "given": "Carmen", "initials": "C"}, {"family": "Rottem", "given": "Menachem", "initials": "M"}, {"family": "Rouadi", "given": "Philip W", "initials": "PW"}, {"family": "Salles", "given": "Nathalie", "initials": "N"}, {"family": "Samolinski", "given": "Boleslaw", "initials": "B"}, {"family": "Santos", "given": "Alexandra F", "initials": "AF"}, {"family": "Serpa", "given": "Faradiba Sarquis", "initials": "FS"}, {"family": "Sastre", "given": "Joaquin", "initials": "J"}, {"family": "Schols", "given": "Jos M G A", "initials": "JMGA"}, {"family": "Scichilone", "given": "Nicola", "initials": "N"}, {"family": "Sediva", "given": "Anna", "initials": "A"}, {"family": "Shamji", "given": "Mohamed H", "initials": "MH"}, {"family": "Sheikh", "given": "Aziz", "initials": "A"}, {"family": "Skypala", "given": "Isabel", "initials": "I"}, {"family": "Smolinska", "given": "Sylwia", "initials": "S"}, {"family": "Sokolowska", "given": "Milena", "initials": "M"}, {"family": "Sousa-Pinto", "given": "Bernardo", "initials": "B"}, {"family": "Sova", "given": "Milan", "initials": "M"}, {"family": "Stelmach", "given": "Rafael", "initials": "R"}, {"family": "Sturm", "given": "Gunter", "initials": "G"}, {"family": "Suppli Ulrik", "given": "Charlotte", "initials": "C"}, {"family": "Todo-Bom", "given": "Ana Maria", "initials": "AM"}, {"family": "Toppila-Salmi", "given": "Sanna", "initials": "S"}, {"family": "Tsiligianni", "given": "Ioanna", "initials": "I"}, {"family": "Torres", "given": "Maria", "initials": "M"}, {"family": "Untersmayr", "given": "Eva", "initials": "E"}, {"family": "Urrutia Pereira", "given": "Marilyn", "initials": "M"}, {"family": "Valiulis", "given": "Arunas", "initials": "A"}, {"family": "Vitte", "given": "Joana", "initials": "J"}, {"family": "Vultaggio", "given": "Alessandra", "initials": "A"}, {"family": "Wallace", "given": "Dana", "initials": "D"}, {"family": "Walusiak-Skorupa", "given": "Jolanta", "initials": "J"}, {"family": "Wang", "given": "De-Yun", "initials": "DY"}, {"family": "Waserman", "given": "Susan", "initials": "S"}, {"family": "Yorgancioglu", "given": "Arzu", "initials": "A"}, {"family": "Yusuf", "given": "Osman M", "initials": "OM"}, {"family": "Zernotti", "given": "Mario", "initials": "M"}, {"family": "Zidarn", "given": "Mihaela", "initials": "M"}, {"family": "Chivato", "given": "Tomas", "initials": "T"}, {"family": "Akdis", "given": "Cezmi A", "initials": "CA"}, {"family": "Zuberbier", "given": "Torsten", "initials": "T"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}], "type": "journal article", "published": "2021-04-02", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": null, "issue": null, "issn-l": "0105-4538"}, "abstract": "Older adults, especially men and/or those with diabetes, hypertension and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritised to receive COVID-19 vaccines due to high risk of death. In very rare instances,the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society)Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients.", "doi": "10.1111/all.14838", "pmid": "33811358", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-06T10:15:54.054Z", "modified": "2021-04-06T10:16:15.682Z"}, {"entity": "publication", "iuid": "8082603cfb84438f9809c0b184885fdc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8082603cfb84438f9809c0b184885fdc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8082603cfb84438f9809c0b184885fdc"}}, "title": "Discovery and in-vitro evaluation of potent SARS-CoV-2 entry inhibitors", "authors": [{"family": "Acharya", "given": "Arpan", "initials": "A"}, {"family": "Pandey", "given": "Kabita", "initials": "K"}, {"family": "Thurman", "given": "Michellie", "initials": "M"}, {"family": "Klug", "given": "Elizabeth", "initials": "E"}, {"family": "Trivedi", "given": "Jay", "initials": "J"}, {"family": "Lorson", "given": "Christian L", "initials": "CL"}, {"family": "Singh", "given": "Kamal", "initials": "K"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}], "type": "posted-content", "published": "2021-04-02", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.02.438204", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-08T19:11:49.891Z", "modified": "2021-04-13T14:00:41.357Z"}, {"entity": "publication", "iuid": "ce0079b35926485894db26d862a5b815", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ce0079b35926485894db26d862a5b815.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ce0079b35926485894db26d862a5b815"}}, "title": "Timing of COVID-19 Vaccine in the setting of anti-CD20 Therapy: A Primer for Nephrologists.", "authors": [{"family": "Kant", "given": "Sam", "initials": "S"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Salas", "given": "Antonio", "initials": "A"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Geetha", "given": "Duvuru", "initials": "D"}], "type": "editorial", "published": "2021-04-01", "journal": {"title": "Kidney Int Rep", "issn": "2468-0249", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.ekir.2021.03.876", "pmid": "33821223", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2468-0249(21)01023-8"}, {"db": "pmc", "key": "PMC8012272"}], "notes": [], "created": "2021-04-07T10:09:52.138Z", "modified": "2021-04-07T10:09:52.160Z"}, {"entity": "publication", "iuid": "caaa85e601364323bba233d68338fc43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/caaa85e601364323bba233d68338fc43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/caaa85e601364323bba233d68338fc43"}}, "title": "Recommendations for accurate genotyping of SARS-CoV-2 using amplicon-based sequencing of clinical samples.", "authors": [{"family": "Kubik", "given": "Slawomir", "initials": "S"}, {"family": "Marques", "given": "Ana Claudia", "initials": "AC"}, {"family": "Xing", "given": "Xiaobin", "initials": "X"}, {"family": "Silvery", "given": "Janine", "initials": "J"}, {"family": "Bertelli", "given": "Claire", "initials": "C"}, {"family": "De Maio", "given": "Flavio", "initials": "F"}, {"family": "Pournaras", "given": "Spyros", "initials": "S"}, {"family": "Burr", "given": "Tom", "initials": "T"}, {"family": "Duffourd", "given": "Yannis", "initials": "Y"}, {"family": "Siemens", "given": "Helena", "initials": "H"}, {"family": "Alloui", "given": "Chakib", "initials": "C"}, {"family": "Song", "given": "Lin", "initials": "L"}, {"family": "Wenger", "given": "Yvan", "initials": "Y"}, {"family": "Saitta", "given": "Alexandra", "initials": "A"}, {"family": "Macheret", "given": "Morgane", "initials": "M"}, {"family": "Smith", "given": "Ewan W", "initials": "EW"}, {"family": "Menu", "given": "Philippe", "initials": "P"}, {"family": "Brayer", "given": "Marion", "initials": "M"}, {"family": "Steinmetz", "given": "Lars M", "initials": "LM"}, {"family": "Si-Mohammed", "given": "Ali", "initials": "A"}, {"family": "Chuisseu", "given": "Josiane", "initials": "J"}, {"family": "Stevens", "given": "Richard", "initials": "R"}, {"family": "Constantoulakis", "given": "Pantelis", "initials": "P"}, {"family": "Sali", "given": "Michela", "initials": "M"}, {"family": "Greub", "given": "Gilbert", "initials": "G"}, {"family": "Tiemann", "given": "Carsten", "initials": "C"}, {"family": "Pelechano", "given": "Vicent", "initials": "V"}, {"family": "Willig", "given": "Adrian", "initials": "A"}, {"family": "Xu", "given": "Zhenyu", "initials": "Z"}], "type": "journal article", "published": "2021-04-01", "journal": {"title": "Clin Microbiol Infect", "issn": "1469-0691", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "SARS-CoV-2 genotyping has been instrumental to monitor viral evolution and transmission during the pandemic. The quality of the sequence data obtained from these genotyping efforts depends on several factors, including the quantity/integrity of the input material, the technology as well as laboratory-specific implementation. The current lack of guidelines for SARS-CoV-2 genotyping leads to inclusion of error-containing genome sequences in genomic epidemiology studies. We aimed at establishing clear and broadly applicable recommendations for reliable virus genotyping.\r\n\r\nWe established and used a sequencing data analysis workflow that reliably identifies and removes technical artifacts, which can result in miscalls when using alternative pipelines, to process clinical samples and synthetic viral genomes with an amplicon-based genotyping approach. We evaluated the impact of experimental factors, including viral load and sequencing depth, on correct sequence determination.\r\n\r\nWe found that at least 1000 viral genomes are necessary to confidently detect variants in the SARS-CoV-2 genome at frequencies of 10% or higher. The broad applicability of our recommendations was validated in over 200 clinical samples from six independent laboratories. The genotypes we determined for clinical isolates with sufficient quality cluster by sampling location and period. Our analysis also supports the rise in frequency of 20A.EU1 and 20A.EU2, two recently reported European strains whose dissemination was facilitated by travelling during the summer of 2020.\r\n\r\nWe present much-needed recommendations for reliable determination of SARS-CoV-2 genome sequence and demonstrate their broad applicability in a large cohort of clinical samples.", "doi": "10.1016/j.cmi.2021.03.029", "pmid": "33813118", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(21)00164-6"}, {"db": "URL", "key": "https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(21)00164-6/fulltext#appsec1", "description": "Data generated with clinical samples can be requested using this information (not suitable for public sharing)"}, {"db": "URL", "key": "https://www.ncbi.nlm.nih.gov/bioproject/PRJNA681574/", "description": "Alternative direct link to SRA (accession: PRJNA681574)"}, {"db": "SRA", "key": "PRJNA681574", "description": "Datasets generated with synthetic SARS-CoV-2 genome"}], "notes": [], "created": "2021-04-06T10:07:38.680Z", "modified": "2021-11-18T11:50:20.495Z"}, {"entity": "publication", "iuid": "60195903649d4bde89045ff87647bbd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60195903649d4bde89045ff87647bbd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60195903649d4bde89045ff87647bbd0"}}, "title": "Maintenance of Acute Stroke Care Service During the COVID-19 Pandemic Lockdown.", "authors": [{"family": "Altersberger", "given": "Valerian L", "initials": "VL"}, {"family": "Stolze", "given": "Lotte J", "initials": "LJ"}, {"family": "Heldner", "given": "Mirjam R", "initials": "MR"}, {"family": "Henon", "given": "Hilde", "initials": "H"}, {"family": "Martinez-Majander", "given": "Nicolas", "initials": "N"}, {"family": "Hametner", "given": "Christian", "initials": "C"}, {"family": "Nordanstig", "given": "Annika", "initials": "A"}, {"family": "Zini", "given": "Andrea", "initials": "A"}, {"family": "Nannoni", "given": "Stefania", "initials": "S"}, {"family": "Gon\u00e7alves", "given": "Bruno", "initials": "B"}, {"family": "Nolte", "given": "Christian H", "initials": "CH"}, {"family": "Baumgartner", "given": "Philipp", "initials": "P"}, {"family": "Kastrup", "given": "Andreas", "initials": "A"}, {"family": "Papanagiotou", "given": "Panagiotis", "initials": "P"}, {"family": "K\u00e4gi", "given": "Georg", "initials": "G"}, {"family": "Leker", "given": "Ronen R", "initials": "RR"}, {"family": "Zedde", "given": "Marialuisa", "initials": "M"}, {"family": "Padovani", "given": "Alessandro", "initials": "A"}, {"family": "Pezzini", "given": "Alessandro", "initials": "A"}, {"family": "Padjen", "given": "Visnja", "initials": "V"}, {"family": "Cereda", "given": "Carlo W", "initials": "CW"}, {"family": "Ntaios", "given": "Georges", "initials": "G"}, {"family": "Bonati", "given": "Leo H", "initials": "LH"}, {"family": "Rinkel", "given": "Leon A", "initials": "LA"}, {"family": "Fischer", "given": "Urs", "initials": "U"}, {"family": "Scheitz", "given": "Jan F", "initials": "JF"}, {"family": "Wegener", "given": "Susanne", "initials": "S"}, {"family": "Turc", "given": "Guillaume", "initials": "G"}, {"family": "Michel", "given": "Patrik", "initials": "P"}, {"family": "Gentile", "given": "Mauro", "initials": "M"}, {"family": "Rentzos", "given": "Alexandros", "initials": "A"}, {"family": "Ringleb", "given": "Peter A", "initials": "PA"}, {"family": "Curtze", "given": "Sami", "initials": "S"}, {"family": "Cordonnier", "given": "Charlotte", "initials": "C"}, {"family": "Arnold", "given": "Marcel", "initials": "M"}, {"family": "Nederkoorn", "given": "Paul J", "initials": "PJ"}, {"family": "Engelter", "given": "Stefan T", "initials": "ST"}, {"family": "Gensicke", "given": "Henrik", "initials": "H"}, {"family": "TRISP Collaborators", "given": "", "initials": ""}], "type": "journal article", "published": "2021-04-01", "journal": {"title": "Stroke", "issn": "1524-4628", "volume": null, "issue": null, "pages": "STROKEAHA120032176", "issn-l": null}, "abstract": "Timely reperfusion is an important goal in treatment of eligible patients with acute ischemic stroke. However, during the coronavirus disease 2019 (COVID-19) pandemic, prehospital and in-hospital emergency procedures faced unprecedented challenges, which might have caused a decline in the number of acute reperfusion therapy applied and led to a worsening of key quality measures for this treatment during lockdown.\n\nThis prospective multicenter cohort study used data from the TRISP (Thrombolysis in Ischemic Stroke Patients) registry of patients with acute ischemic stroke treated with reperfusion therapies, that is, intravenous thrombolysis or endovascular therapy. We compared prehospital and in-hospital time-based performance measures (stroke-onset-to-admission, admission-to-treatment, admission-to-image, and image-to-treatment time) during the first 6 weeks after announcement of lockdown (lockdown period) with the same period in 2019 (reference period). Secondary outcomes included stroke severity (National Institutes of Health Stroke Scale) after 24 hours and occurrence of symptomatic intracranial hemorrhage (following the ECASS [European-Australasian Acute Stroke Study]-II criteria).\n\nAcross 20 stroke centers, 540 patients were treated with intravenous thrombolysis/endovascular therapy during lockdown period compared with 578 patients during reference period (-7% [95% CI, 5%-9%]). Performance measures did not change significantly during the lockdown period (2020/2019 minutes median: onset-to-admission 133/145; admission-to-treatment 51/48). Same was true for admission-to-image (20/19) and image-to-treatment (31/30) time in patients with available time of first image (n=871, 77.9%). Median National Institutes of Health Stroke Scale on admission (2020/2019: 11/11) and after 24 hours (2020/2019: 6/5) and percentage of symptomatic intracranial hemorrhage (2020/2019: 6.2/5.7) did not differ significantly between both periods.\n\nThe COVID-19 pandemic lockdown resulted in a mild decline in the number of patients with stroke treated with acute reperfusion therapies. More importantly, the solid stability of key quality performance measures between the 2020 and 2019 period may indicate resilience of acute stroke care service during the lockdown, at least in well-established European stroke centers.", "doi": "10.1161/STROKEAHA.120.032176", "pmid": "33793320", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-06T10:42:44.558Z", "modified": "2021-04-06T10:42:44.569Z"}, {"entity": "publication", "iuid": "d31d1eec18a14cf2a8bd848d0d096265", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d31d1eec18a14cf2a8bd848d0d096265.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d31d1eec18a14cf2a8bd848d0d096265"}}, "title": "Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites", "authors": [{"family": "Hoffmann", "given": "David", "initials": "D"}, {"family": "Mereiter", "given": "Stefan", "initials": "S", "orcid": "0000-0002-4832-3090", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1974c14a7be4583a96ceecccbda4f19.json"}}, {"family": "Oh", "given": "Yoo Jin", "initials": "YJ", "orcid": "0000-0002-9636-3329", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6887c6a78da44881aa30920d96f17d8f.json"}}, {"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Zhu", "given": "Rong", "initials": "R"}, {"family": "Canena", "given": "Daniel", "initials": "D"}, {"family": "Hain", "given": "Lisa", "initials": "L"}, {"family": "Laurent", "given": "Elisabeth", "initials": "E"}, {"family": "Gr\u00fcnwald-Gruber", "given": "Clemens", "initials": "C"}, {"family": "Novatchkova", "given": "Maria", "initials": "M"}, {"family": "Ticevic", "given": "Melita", "initials": "M"}, {"family": "Chabloz", "given": "Antoine", "initials": "A"}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G"}, {"family": "Hagelkruys", "given": "Astrid", "initials": "A"}, {"family": "Altmann", "given": "Friedrich", "initials": "F"}, {"family": "Mach", "given": "Lukas", "initials": "L", "orcid": "0000-0001-9013-5408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e58ab479be1e4abd9f95f0c5737f280b.json"}}, {"family": "Stadlmann", "given": "Johannes", "initials": "J"}, {"family": "Oostenbrink", "given": "Chris", "initials": "C"}, {"family": "Mirazimi", "given": "Ali", "initials": "A", "orcid": "0000-0003-2371-6055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0651be47429c4e5880a13b839d04fe1d.json"}}, {"family": "Hinterdorfer", "given": "Peter", "initials": "P"}, {"family": "Penninger", "given": "Josef M", "initials": "JM", "orcid": "0000-0002-8194-3777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e56aaa008524272bf252df804e06991.json"}}], "type": "posted-content", "published": "2021-04-01", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.01.438087", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-06-09T11:13:03.497Z", "modified": "2021-08-23T14:40:45.988Z"}, {"entity": "publication", "iuid": "5e7d630904214962b1b9fca8e55d053c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e7d630904214962b1b9fca8e55d053c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e7d630904214962b1b9fca8e55d053c"}}, "title": "Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge.", "authors": [{"family": "Winkler", "given": "Martin S", "initials": "MS"}, {"family": "Skirecki", "given": "Tomasz", "initials": "T"}, {"family": "Brunkhorst", "given": "Frank M", "initials": "FM"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "Cavaillon", "given": "Jean-Marc", "initials": "JM"}, {"family": "Ferrer", "given": "Ricard", "initials": "R"}, {"family": "Floh\u00e9", "given": "Stefanie B", "initials": "SB"}, {"family": "Garc\u00eda-Salido", "given": "Alberto", "initials": "A"}, {"family": "Giamarellos-Bourboulis", "given": "Evangelos J", "initials": "EJ"}, {"family": "Girardis", "given": "Massimo", "initials": "M"}, {"family": "Kox", "given": "Matthijs", "initials": "M"}, {"family": "Lachmann", "given": "Gunnar", "initials": "G"}, {"family": "Martin-Loeches", "given": "Ignacio", "initials": "I"}, {"family": "Netea", "given": "Mihai G", "initials": "MG"}, {"family": "Spinetti", "given": "Thibaud", "initials": "T"}, {"family": "Schefold", "given": "Joerg C", "initials": "JC"}, {"family": "Torres", "given": "Antoni", "initials": "A"}, {"family": "Uhle", "given": "Florian", "initials": "F"}, {"family": "Venet", "given": "Fabienne", "initials": "F"}, {"family": "Weis", "given": "Sebastian", "initials": "S"}, {"family": "Scherag", "given": "Andr\u00e9", "initials": "A"}, {"family": "Rubio", "given": "Ignacio", "initials": "I"}, {"family": "Osuchowski", "given": "Marcin F", "initials": "MF"}], "type": "journal article", "published": "2021-04-01", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "volume": "66", "issue": null, "pages": "103291", "issn-l": null}, "abstract": "Many milestones in medical history rest on animal modeling of human diseases. The SARS-CoV-2 pandemic has evoked a tremendous investigative effort primarily centered on clinical studies. However, several animal SARS-CoV-2/COVID-19 models have been developed and pre-clinical findings aimed at supporting clinical evidence rapidly emerge. In this review, we characterize the existing animal models exposing their relevance and limitations as well as outline their utility in COVID-19 drug and vaccine development. Concurrently, we summarize the status of clinical trial research and discuss the novel tactics utilized in the largest multi-center trials aiming to accelerate generation of reliable results that may subsequently shape COVID-19 clinical treatment practices. We also highlight areas of improvement for animal studies in order to elevate their translational utility. In pandemics, to optimize the use of strained resources in a short time-frame, optimizing and strengthening the synergy between the preclinical and clinical domains is pivotal.", "doi": "10.1016/j.ebiom.2021.103291", "pmid": "33813139", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2352-3964(21)00084-0"}], "notes": [], "created": "2021-04-06T10:06:30.011Z", "modified": "2021-04-06T10:06:30.022Z"}, {"entity": "publication", "iuid": "8ed7dd2bcc9d426189a98e28e0f3d1f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ed7dd2bcc9d426189a98e28e0f3d1f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ed7dd2bcc9d426189a98e28e0f3d1f2"}}, "title": "Using the COVID-19 pandemic to reimagine global health teaching in high-income countries.", "authors": [{"family": "Atkins", "given": "Salla", "initials": "S"}, {"family": "Banerjee", "given": "Ananya Tina", "initials": "AT"}, {"family": "Bachynski", "given": "Kathleen", "initials": "K"}, {"family": "Daftary", "given": "Amrita", "initials": "A"}, {"family": "Desai", "given": "Gauri", "initials": "G"}, {"family": "Gross", "given": "Aeyal", "initials": "A"}, {"family": "Hedt-Gauthier", "given": "Bethany", "initials": "B"}, {"family": "Mendenhall", "given": "Emily", "initials": "E"}, {"family": "Meier", "given": "Benjamin Mason", "initials": "BM"}, {"family": "Nixon", "given": "Stephanie A", "initials": "SA"}, {"family": "Nolan", "given": "Ann", "initials": "A"}, {"family": "Palermo", "given": "Tia M", "initials": "TM"}, {"family": "Phelan", "given": "Alexandra", "initials": "A"}, {"family": "Pyzik", "given": "Oksana", "initials": "O"}, {"family": "Roach", "given": "Pamela", "initials": "P"}, {"family": "Sangaramoorthy", "given": "Thurka", "initials": "T"}, {"family": "Standley", "given": "Claire J", "initials": "CJ"}, {"family": "Yamey", "given": "Gavin", "initials": "G"}, {"family": "Abimbola", "given": "Seye", "initials": "S"}, {"family": "Pai", "given": "Madhukar", "initials": "M"}], "type": "editorial", "published": "2021-04-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "4", "issn-l": "2059-7908"}, "abstract": null, "doi": "10.1136/bmjgh-2021-005649", "pmid": "33811100", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-005649"}], "notes": [], "created": "2021-04-06T10:22:25.858Z", "modified": "2021-04-06T10:22:25.868Z"}, {"entity": "publication", "iuid": "95af88ba4a9a4369936c0f0d5dcea2d8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95af88ba4a9a4369936c0f0d5dcea2d8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95af88ba4a9a4369936c0f0d5dcea2d8"}}, "title": "Undiagnosed SARS-CoV-2 infection and outcome in patients with acute MI and no COVID-19 symptoms.", "authors": [{"family": "Akhtar", "given": "Zubair", "initials": "Z"}, {"family": "Chowdhury", "given": "Fahmida", "initials": "F"}, {"family": "Aleem", "given": "Mohammad Abdul", "initials": "MA"}, {"family": "Ghosh", "given": "Probir Kumar", "initials": "PK"}, {"family": "Rahman", "given": "Mahmudur", "initials": "M"}, {"family": "Rahman", "given": "Mustafizur", "initials": "M"}, {"family": "Hossain", "given": "Mohammad Enayet", "initials": "ME"}, {"family": "Sumiya", "given": "Mariya Kibtiya", "initials": "MK"}, {"family": "Islam", "given": "A K M Monwarul", "initials": "AKMM"}, {"family": "Uddin", "given": "Mir Jamal", "initials": "MJ"}, {"family": "MacIntyre", "given": "C Raina", "initials": "CR"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "Frobert", "given": "Ole", "initials": "O"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Open Heart", "issn": "2053-3624", "volume": "8", "issue": "1", "issn-l": null}, "abstract": "We aimed to determine the prevalence and outcome of occult infection with SARS-CoV-2 and influenza in patients presenting with myocardial infarction (MI) without COVID-19 symptoms.\n\nWe conducted an observational study from 28 June to 11 August 2020, enrolling patients admitted to the National Institute of Cardiovascular Disease Hospital, Dhaka, Bangladesh, with ST-segment elevation MI (STEMI) or non-ST-segment elevation MI who did not meet WHO criteria for suspected COVID-19. Samples were collected by nasopharyngeal swab to test for SARS-CoV-2 and influenza virus by real-time reverse transcriptase PCR. We followed up patients at 3 months (13 weeks) postadmission to record adverse cardiovascular outcomes: all-cause death, new MI, heart failure and new percutaneous coronary intervention or stent thrombosis. Survival analysis was performed using the Kaplan-Meier method.\n\nWe enrolled 280 patients with MI, 79% male, mean age 54.5\u00b111.8 years, 140 of whom were diagnosed with STEMI. We found 36 (13%) to be infected with SARS-CoV-2 and 1 with influenza. There was no significant difference between mortality rate observed among SARS-CoV-2 infected patients compared with non-infected (5 (14%) vs 26 (11%); p=0.564). A numerically shorter median time to a recurrent cardiovascular event was recorded among SARS-CoV-2 infected compared with non-infected patients (21 days, IQR: 8-46 vs 27 days, IQR: 7-44; p=0.378).\n\nWe found a substantial rate of occult SARS-CoV-2 infection in the studied cohort, suggesting SARS-CoV-2 may precipitate MI. Asymptomatic patients with COVID-19 admitted with MI may contribute to disease transmission and warrants widespread testing of hospital admissions.", "doi": "10.1136/openhrt-2021-001617", "pmid": "33811137", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "openhrt-2021-001617"}], "notes": [], "created": "2021-04-06T10:19:09.211Z", "modified": "2021-04-06T10:21:37.251Z"}, {"entity": "publication", "iuid": "274bda03653b48a7b4e0a8099fda6a9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/274bda03653b48a7b4e0a8099fda6a9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/274bda03653b48a7b4e0a8099fda6a9c"}}, "title": "Second versus first wave of COVID-19 deaths: Shifts in age distribution and in nursing home fatalities.", "authors": [{"family": "Ioannidis", "given": "John P A", "initials": "JPA"}, {"family": "Axfors", "given": "Cathrine", "initials": "C"}, {"family": "Contopoulos-Ioannidis", "given": "Despina G", "initials": "DG"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Environ Res", "issn": "1096-0953", "volume": "195", "issue": null, "pages": "110856", "issn-l": "0013-9351"}, "abstract": "To examine whether the age distribution of COVID-19 deaths and the share of deaths in nursing homes changed in the second versus the first pandemic wave.\n\nWe considered all countries that had at least 4000 COVID-19 deaths occurring as of January 14, 2021, at least 200 COVID-19 deaths occurring in each of the two epidemic wave periods; and which had sufficiently detailed information available on the age distribution of these deaths. We also considered countries with data available on COVID-19 deaths of nursing home residents for the two waves.\n\nChange in the second wave versus the first wave in the proportion of COVID-19 deaths occurring in people <50 years (\"young deaths\") among all COVID-19 deaths and among COVID-19 deaths in people <70 years old; and change in the proportion of COVID-19 deaths in nursing home residents among all COVID-19 deaths.\n\nData on age distribution were available for 14 eligible countries. Individuals <50 years old had small absolute difference in their share of the total COVID-19 deaths in the two waves across 13 high-income countries (absolute differences 0.0-0.4%). Their proportion was higher in Ukraine, but it decreased markedly in the second wave. The proportion of young deaths was lower in the second versus the first wave (summary prevalence ratio 0.81, 95% CI 0.71-0.92) with large between-country heterogeneity. The proportion of young deaths among deaths <70 years did not differ significantly across the two waves (summary prevalence ratio 0.96, 95% CI 0.86-1.06). Eligible data on nursing home COVID-19 deaths were available for 11 countries. The share of COVID-19 deaths that were accounted by nursing home residents decreased in the second wave significantly and substantially in 8 countries (prevalence ratio estimates: 0.36 to 0.78), remained the same in Denmark and Norway and markedly increased in Australia.\n\nIn the examined countries, age distribution of COVID-19 deaths has been fairly similar in the second versus the first wave, but the contribution of COVID-19 deaths in nursing home residents to total fatalities has decreased in most countries in the second wave.", "doi": "10.1016/j.envres.2021.110856", "pmid": "33581086", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0013-9351(21)00150-X"}, {"db": "pmc", "key": "PMC7875012"}], "notes": [], "created": "2021-02-15T07:51:34.990Z", "modified": "2021-07-14T07:56:41.505Z"}, {"entity": "publication", "iuid": "d302fafc56674dd383657bc91dd6780e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d302fafc56674dd383657bc91dd6780e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d302fafc56674dd383657bc91dd6780e"}}, "title": "Reporting suspicions of long COVID in children is justified during this global emergency.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF", "orcid": "0000-0003-1024-5602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1d5e45881a7469ca20a0eb360d891cc.json"}}], "type": "letter", "published": "2021-04-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": "110", "issue": "4", "pages": "1373"}, "abstract": "I would like to thank Peny and Valind (1) for raising a number of issues with regard to my recent paper in Acta Paediatrica, which was based on parental reports of what appeared to be long COVID in Sweden (2). The parents approached a number of medical professionals, including me, following discussions on social media about how their children were experiencing worrying ongoing symptoms during the current COVID-19 pandemic.", "doi": "10.1111/apa.15762", "pmid": "33459404", "labels": {"Type: Other": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC8013867"}], "notes": [], "created": "2021-01-22T09:17:52.957Z", "modified": "2021-07-09T12:50:41.953Z"}, {"entity": "publication", "iuid": "85e87380177046388d486d1e87652a60", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/85e87380177046388d486d1e87652a60.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/85e87380177046388d486d1e87652a60"}}, "title": "OncoAlert Round Table Discussions: The Global COVID-19 Experience.", "authors": [{"family": "Morgan", "given": "Gilberto", "initials": "G"}, {"family": "de Azambuja", "given": "Evandro", "initials": "E"}, {"family": "Punie", "given": "Kevin", "initials": "K"}, {"family": "Ades", "given": "Felipe", "initials": "F"}, {"family": "Heinrich", "given": "Kathrin", "initials": "K"}, {"family": "Personeni", "given": "Nicola", "initials": "N"}, {"family": "Rahme", "given": "Ramy", "initials": "R"}, {"family": "Ferrara", "given": "Roberto", "initials": "R"}, {"family": "Pels", "given": "Kevin", "initials": "K"}, {"family": "Garassino", "given": "Marina", "initials": "M"}, {"family": "von Bergwelt-Baildon", "given": "Michael", "initials": "M"}, {"family": "Lopes", "given": "Gilberto", "initials": "G"}, {"family": "Barlesi", "given": "Fabrice", "initials": "F"}, {"family": "Choueiri", "given": "Toni K", "initials": "TK"}, {"family": "Burris", "given": "Howard", "initials": "H"}, {"family": "Peters", "given": "Solange", "initials": "S"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "JCO Glob Oncol", "issn": "2687-8941", "volume": "7", "issue": null, "pages": "455-463", "issn-l": null}, "abstract": "The speed and spread of the COVID-19 pandemic has been affecting the entire world for the past several months. OncoAlert is a social media network made up of more than 140 oncology stakeholders: oncologists (medical, radiation, and surgical), oncology nurses, and patient advocates who share the mission of fighting cancer by means of education and dissemination of information. As a response to the COVID-19 pandemic, OncoAlert hosted The Round Table Discussions. We have documented this effort along with further discussion about the COVID-19 pandemic and the consequences on patients living with cancer to disseminate this information to our colleagues worldwide.", "doi": "10.1200/GO.20.00603", "pmid": "33822643", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-07T10:07:54.625Z", "modified": "2021-04-07T10:07:54.648Z"}, {"entity": "publication", "iuid": "ee6c4a2899d04e1682c03838cdd1d575", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee6c4a2899d04e1682c03838cdd1d575.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee6c4a2899d04e1682c03838cdd1d575"}}, "title": "No country or continent is on its own in the ongoing COVID-19 pandemic.", "authors": [{"family": "Johansen", "given": "Kari", "initials": "K"}, {"family": "Nohynek", "given": "Hanna", "initials": "H"}], "type": "editorial", "published": "2021-04-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "17", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2021.26.17.2100430", "pmid": "33928901", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-04T16:03:43.303Z", "modified": "2021-05-04T16:03:43.313Z"}, {"entity": "publication", "iuid": "68d673b1ce8746409bf731b7cf161c36", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68d673b1ce8746409bf731b7cf161c36.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68d673b1ce8746409bf731b7cf161c36"}}, "title": "Next-generation field courses: Integrating Open Science and online learning.", "authors": [{"family": "Geange", "given": "Sonya R", "initials": "SR"}, {"family": "von Oppen", "given": "Jonathan", "initials": "J"}, {"family": "Strydom", "given": "Tanya", "initials": "T"}, {"family": "Boakye", "given": "Mickey", "initials": "M"}, {"family": "Gauthier", "given": "Tasha-Leigh J", "initials": "TJ"}, {"family": "Gya", "given": "Ragnhild", "initials": "R"}, {"family": "Halbritter", "given": "Aud H", "initials": "AH"}, {"family": "Jessup", "given": "Laura H", "initials": "LH"}, {"family": "Middleton", "given": "Sara L", "initials": "SL"}, {"family": "Navarro", "given": "Jocelyn", "initials": "J"}, {"family": "Pierfederici", "given": "Maria Elisa", "initials": "ME"}, {"family": "Chac\u00f3n-Labella", "given": "Julia", "initials": "J"}, {"family": "Cotner", "given": "Sehoya", "initials": "S"}, {"family": "Farfan-Rios", "given": "William", "initials": "W"}, {"family": "Maitner", "given": "Brian S", "initials": "BS"}, {"family": "Michaletz", "given": "Sean T", "initials": "ST"}, {"family": "Telford", "given": "Richard J", "initials": "RJ"}, {"family": "Enquist", "given": "Brian J", "initials": "BJ"}, {"family": "Vandvik", "given": "Vigdis", "initials": "V"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Ecol Evol", "issn": "2045-7758", "volume": "11", "issue": "8", "pages": "3577-3587", "issn-l": null}, "abstract": "As Open Science practices become more commonplace, there is a need for the next generation of scientists to be well versed in these aspects of scientific research. Yet, many training opportunities for early career researchers (ECRs) could better emphasize or integrate Open Science elements. Field courses provide opportunities for ECRs to apply theoretical knowledge, practice new methodological approaches, and gain an appreciation for the challenges of real-life research, and could provide an excellent platform for integrating training in Open Science practices. Our recent experience, as primarily ECRs engaged in a field course interrupted by COVID-19, led us to reflect on the potential to enhance learning outcomes in field courses by integrating Open Science practices and online learning components. Specifically, we highlight the opportunity for field courses to align teaching activities with the recent developments and trends in how we conduct research, including training in: publishing registered reports, collecting data using standardized methods, adopting high-quality data documentation, managing data through reproducible workflows, and sharing and publishing data through appropriate channels. We also discuss how field courses can use online tools to optimize time in the field, develop open access resources, and cultivate collaborations. By integrating these elements, we suggest that the next generation of field courses will offer excellent arenas for participants to adopt Open Science practices.", "doi": "10.1002/ece3.7009", "pmid": "33898010", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "ECE37009"}, {"db": "pmc", "key": "PMC8057340"}], "notes": [], "created": "2021-04-29T15:27:05.229Z", "modified": "2021-04-29T15:27:05.232Z"}, {"entity": "publication", "iuid": "0d45ddfcbc5047b09fbf45d48525b320", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d45ddfcbc5047b09fbf45d48525b320.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d45ddfcbc5047b09fbf45d48525b320"}}, "title": "National outcomes and characteristics of patients admitted to Swedish intensive care units for COVID-19", "authors": [{"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Blixt", "given": "Patrik Johansson", "initials": "PJ"}, {"family": "\u00c5hman", "given": "Rasmus", "initials": "R"}, {"family": "Engerstr\u00f6m", "given": "Lars", "initials": "L"}, {"family": "Andersson", "given": "Henrik", "initials": "H"}, {"family": "Berggren", "given": "Ritva Kiiski", "initials": "RK"}, {"family": "Tegnell", "given": "Anders", "initials": "A"}, {"family": "McIntyre", "given": "Sarah", "initials": "S"}], "type": "journal-article", "published": "2021-04-00", "journal": {"title": "Eur J Anaesthesiol", "issn": "1365-2346", "volume": "38", "issue": "4", "pages": "335-343", "issn-l": null}, "abstract": "Mortality among patients admitted to intensive care units (ICUs) with COVID-19 is unclear due to variable follow-up periods. Few nationwide data are available to compare risk factors, treatment and outcomes of COVID-19 patients after ICU admission.\n\nTo evaluate baseline characteristics, treatments and 30-day outcomes of patients admitted to Swedish ICUs with COVID-19.\n\nRegistry-based cohort study with prospective data collection.\n\nAdmissions to Swedish ICUs from 6 March to 6 May 2020 with laboratory confirmed COVID-19 disease.\n\nAdult patients admitted to Swedish ICUs.\n\nBaseline characteristics, intensive care treatments and organ failures.\n\nThe primary outcome was 30-day all-cause mortality. A multivariable model was used to determine the independent association between potential predictor variables and death.\n\nWe identified 1563 patients with complete 30-day follow-up. The 30-day all-cause mortality was 26.7%. Median age was 61 [52 to 69], Simplified Acute Physiology Score III (SAPS III) was 53 [46 to 59] and 62.5% had at least one comorbidity. Median PaO2/FiO2 on admission was 97.5 [75.0 to 140.6] mmHg, 74.7% suffered from moderate-to-severe acute respiratory failure. Age, male sex [adjusted odds ratio (aOR) 1.5 (1.1 to 2.2)], SAPS III score [aOR 1.3 (1.2 to 1.4)], severe respiratory failure [aOR 3.0 (2.0 to 4.7)], specific COVID-19 pharmacotherapy [aOR 1.4 (1.0 to 1.9)] and continuous renal replacement therapy [aOR 2.1 (1.5 to 3.0)] were associated with increased mortality. Except for chronic lung disease, the presence of comorbidities was not independently associated with mortality.\n\nThirty-day mortality rate in COVID-19 patients admitted to Swedish ICUs is generally lower than previously reported despite a severe degree of hypoxaemia on admission. Mortality was driven by age, baseline disease severity, the presence and degree of organ failure, rather than pre-existing comorbidities.\n\nNCT04462393.", "doi": "10.1097/eja.0000000000001459", "pmid": "33534266", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00003643-900000000-98244"}, {"db": "ClinicalTrials.gov", "key": "NCT04462393"}], "notes": [], "created": "2021-02-04T18:11:08.535Z", "modified": "2021-06-18T11:08:26.474Z"}, {"entity": "publication", "iuid": "980eb41a0b4c42ee9233958785cdf896", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/980eb41a0b4c42ee9233958785cdf896.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/980eb41a0b4c42ee9233958785cdf896"}}, "title": "Meteorological conditions are heterogeneous factors for COVID-19 risk in China", "authors": [{"family": "Xiao", "given": "Shuang", "initials": "S"}, {"family": "Qi", "given": "Hongchao", "initials": "H"}, {"family": "Ward", "given": "Michael P", "initials": "MP"}, {"family": "Wang", "given": "Wenge", "initials": "W"}, {"family": "Zhang", "given": "Jun", "initials": "J"}, {"family": "Chen", "given": "Yue", "initials": "Y"}, {"family": "Bergquist", "given": "Robert", "initials": "R"}, {"family": "Tu", "given": "Wei", "initials": "W"}, {"family": "Shi", "given": "Runye", "initials": "R"}, {"family": "Hong", "given": "Jie", "initials": "J"}, {"family": "Su", "given": "Qing", "initials": "Q"}, {"family": "Zhao", "given": "Zheng", "initials": "Z"}, {"family": "Ba", "given": "Jianbo", "initials": "J"}, {"family": "Zhang", "given": "Zhijie", "initials": "Z"}], "type": "journal-article", "published": "2021-04-00", "journal": {"title": "Environ Res", "issn": "0013-9351", "volume": null, "issue": null, "pages": "111182", "issn-l": null}, "abstract": null, "doi": "10.1016/j.envres.2021.111182", "pmid": null, "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-04-20T17:52:22.865Z", "modified": "2021-04-23T16:06:36.046Z"}, {"entity": "publication", "iuid": "15dfd044b9124bebb7e41ae9a130eb62", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15dfd044b9124bebb7e41ae9a130eb62.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15dfd044b9124bebb7e41ae9a130eb62"}}, "title": "Long-Haul Post-COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrome: The Swedish Experience.", "authors": [{"family": "Johansson", "given": "Madeleine", "initials": "M"}, {"family": "St\u00e5hlberg", "given": "Marcus", "initials": "M"}, {"family": "Runold", "given": "Michael", "initials": "M"}, {"family": "Nygren-Bonnier", "given": "Malin", "initials": "M"}, {"family": "Nilsson", "given": "Jan", "initials": "J"}, {"family": "Olshansky", "given": "Brian", "initials": "B"}, {"family": "Bruchfeld", "given": "Judith", "initials": "J"}, {"family": "Fedorowski", "given": "Artur", "initials": "A"}], "type": "case reports", "published": "2021-04-00", "journal": {"title": "JACC Case Rep", "issn": "2666-0849", "issn-l": null, "volume": "3", "issue": "4", "pages": "573-580"}, "abstract": "Major clinical centers in Sweden have witnessed an inflow of patients with chronic symptoms following initial outpatient care for coronavirus disease-2019 (COVID-19) infection, suggestive of postural orthostatic tachycardia syndrome. This report presents the first case series of 3 Swedish patients diagnosed with postural orthostatic tachycardia syndrome more than 3 months after the primary COVID-2019 infections. (Level of Difficulty: Intermediate.).", "doi": "10.1016/j.jaccas.2021.01.009", "pmid": "33723532", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Rehabilitation": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "S2666-0849(21)00100-5"}, {"db": "pmc", "key": "PMC7946344"}], "notes": [], "created": "2021-03-17T07:42:54.636Z", "modified": "2021-11-18T12:53:34.532Z"}, {"entity": "publication", "iuid": "7aea0412da344b4f9e2e8ac34ab5196d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7aea0412da344b4f9e2e8ac34ab5196d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7aea0412da344b4f9e2e8ac34ab5196d"}}, "title": "Long COVID-19\u2014it's not over until?", "authors": [{"family": "Yelin", "given": "Dana", "initials": "D"}, {"family": "Margalit", "given": "Ili", "initials": "I"}, {"family": "Yahav", "given": "Dafna", "initials": "D"}, {"family": "Runold", "given": "Michael", "initials": "M"}, {"family": "Bruchfeld", "given": "Judith", "initials": "J"}], "type": "journal-article", "published": "2021-04-00", "journal": {"title": "Clinical Microbiology and Infection", "issn": "1198-743X", "issn-l": null, "volume": "27", "issue": "4", "pages": "506-508"}, "abstract": null, "doi": "10.1016/j.cmi.2020.12.001", "pmid": "33316400", "labels": {"Type: Other": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(20)30750-3"}], "notes": [], "created": "2020-12-21T10:16:50.007Z", "modified": "2021-07-09T12:52:27.295Z"}, {"entity": "publication", "iuid": "1abc7e14a86640049e495cf1c27e887e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1abc7e14a86640049e495cf1c27e887e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1abc7e14a86640049e495cf1c27e887e"}}, "title": "Incidence of SARS-CoV-2 in people with cystic fibrosis in Europe between February and June 2020", "authors": [{"family": "Naehrlich", "given": "Lutz", "initials": "L"}, {"family": "Orenti", "given": "Annalisa", "initials": "A"}, {"family": "Dunlevy", "given": "Fiona", "initials": "F"}, {"family": "Kasmi", "given": "Irena", "initials": "I"}, {"family": "Harutyunyan", "given": "Satenik", "initials": "S"}, {"family": "Pfleger", "given": "Andreas", "initials": "A"}, {"family": "Keegan", "given": "Svetlana", "initials": "S"}, {"family": "Daneau", "given": "G\u00e9raldine", "initials": "G"}, {"family": "Petrova", "given": "Guergana", "initials": "G"}, {"family": "Tje\u0161i\u0107-Drinkovi\u0107", "given": "Du\u0161ka", "initials": "D"}, {"family": "Yiallouros", "given": "Panayiotis", "initials": "P"}, {"family": "Bilkova", "given": "Alena", "initials": "A"}, {"family": "Olesen", "given": "Hanne Vebert", "initials": "HV"}, {"family": "Burgel", "given": "Pierre R\u00e9gis", "initials": "PR"}, {"family": "Parulava", "given": "Tsitsino", "initials": "T"}, {"family": "Diamantea", "given": "Filia", "initials": "F"}, {"family": "P\u00e1rniczky", "given": "Andrea", "initials": "A"}, {"family": "McKone", "given": "Edward F", "initials": "EF"}, {"family": "Mei-Zahav", "given": "Meir", "initials": "M"}, {"family": "Salvatore", "given": "Marco", "initials": "M"}, {"family": "Colombo", "given": "Carla", "initials": "C"}, {"family": "Aleksejeva", "given": "Elina", "initials": "E"}, {"family": "Malakauskas", "given": "Kestutis", "initials": "K"}, {"family": "Schlesser", "given": "Marc", "initials": "M"}, {"family": "Fustik", "given": "Stojka", "initials": "S"}, {"family": "Turcu", "given": "Oxana", "initials": "O"}, {"family": "Zomer-van Ommen", "given": "Domenique", "initials": "D"}, {"family": "Wathne", "given": "Anita Senstad", "initials": "AS"}, {"family": "Wo\u017aniacki", "given": "\u0141ukasz", "initials": "\u0141"}, {"family": "Pereira", "given": "Lu\u00edsa", "initials": "L"}, {"family": "Pop", "given": "Liviu", "initials": "L"}, {"family": "Kashirskaya", "given": "Nataliya", "initials": "N"}, {"family": "Rodi\u0107", "given": "Milan", "initials": "M"}, {"family": "Kayserova", "given": "Hana", "initials": "H"}, {"family": "Krivecs", "given": "Uro", "initials": "U"}, {"family": "Mondejar-Lopez", "given": "Pedro", "initials": "P"}, {"family": "de Monestrol", "given": "Isabelle", "initials": "I"}, {"family": "Dogru", "given": "Deniz", "initials": "D"}, {"family": "Makukh", "given": "Halyna", "initials": "H"}, {"family": "Cosgriff", "given": "Rebecca", "initials": "R"}, {"family": "van Koningsbruggen-Rietschel", "given": "Silke", "initials": "S"}, {"family": "Jung", "given": "Andreas", "initials": "A"}, {"family": "Bobrovnichy", "given": "Vladimir", "initials": "V"}, {"family": "Bambir", "given": "Ivan", "initials": "I"}, {"family": "Vukic", "given": "Andrea Dugac", "initials": "AD"}, {"family": "Drevinek", "given": "Pavel", "initials": "P"}, {"family": "Jr", "given": "Milan Macek", "initials": "MM"}, {"family": "Corvol", "given": "Harriet", "initials": "H"}, {"family": "Lemonnier-Videau", "given": "Lydie", "initials": "L"}, {"family": "Hatziagorou", "given": "Elpis", "initials": "E"}, {"family": "Fletcher", "given": "Godfrey", "initials": "G"}, {"family": "Padoan", "given": "Rita", "initials": "R"}, {"family": "Gulmans", "given": "Vincent", "initials": "V"}, {"family": "Bakkeheim", "given": "Egil", "initials": "E"}, {"family": "Kondratyeva", "given": "Elena", "initials": "E"}, {"family": "Amelina", "given": "Elena", "initials": "E"}, {"family": "Zhekaite", "given": "Elena", "initials": "E"}, {"family": "Simonova", "given": "Olga", "initials": "O"}, {"family": "Pastor-Vivero", "given": "Maria Dolores", "initials": "MD"}, {"family": "Lindblad", "given": "Anders", "initials": "A"}, {"family": "G\u00f6kdemir", "given": "Yasemin", "initials": "Y"}, {"family": "Pekcan", "given": "Sevgi", "initials": "S"}, {"family": "Brownlee", "given": "Keith", "initials": "K"}, {"family": "McClenaghan", "given": "Elliott", "initials": "E"}, {"family": "Carr", "given": "Siobh\u00e1n", "initials": "S"}, {"family": "Lammertyn", "given": "Elise", "initials": "E"}, {"family": "Zolin", "given": "Anna", "initials": "A"}, {"family": "Fox", "given": "Alice", "initials": "A"}, {"family": "Krasnyk", "given": "Marko", "initials": "M"}, {"family": "Van Rens", "given": "Jacqui", "initials": "J"}], "type": "journal-article", "published": "2021-04-00", "journal": {"title": "Journal of Cystic Fibrosis", "issn": "1569-1993", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.jcf.2021.03.017", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-21T17:25:33.722Z", "modified": "2021-05-21T17:25:55.844Z"}, {"entity": "publication", "iuid": "1782e69f4e5249c29b177151ee5e172b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1782e69f4e5249c29b177151ee5e172b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1782e69f4e5249c29b177151ee5e172b"}}, "title": "From a crisis to an opportunity: Eight insights for doing science in the COVID-19 era and beyond.", "authors": [{"family": "Chac\u00f3n-Labella", "given": "Julia", "initials": "J"}, {"family": "Boakye", "given": "Mickey", "initials": "M"}, {"family": "Enquist", "given": "Brian J", "initials": "BJ"}, {"family": "Farfan-Rios", "given": "William", "initials": "W"}, {"family": "Gya", "given": "Ragnhild", "initials": "R"}, {"family": "Halbritter", "given": "Aud H", "initials": "AH"}, {"family": "Middleton", "given": "Sara L", "initials": "SL"}, {"family": "von Oppen", "given": "Jonathan", "initials": "J"}, {"family": "Pastor-Ploskonka", "given": "Samuel", "initials": "S"}, {"family": "Strydom", "given": "Tanya", "initials": "T"}, {"family": "Vandvik", "given": "Vigdis", "initials": "V"}, {"family": "Geange", "given": "Sonya R", "initials": "SR"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Ecol Evol", "issn": "2045-7758", "volume": "11", "issue": "8", "pages": "3588-3596", "issn-l": null}, "abstract": "The COVID-19 crisis has forced researchers in Ecology to change the way we work almost overnight. Nonetheless, the pandemic has provided us with several novel components for a new way of conducting science. In this perspective piece, we summarize eight central insights that are helping us, as early career researchers, navigate the uncertainties, fears, and challenges of advancing science during the COVID-19 pandemic. We highlight how innovative, collaborative, and often Open Science-driven developments that have arisen from this crisis can form a blueprint for a community reinvention in academia. Our insights include personal approaches to managing our new reality, maintaining capacity to focus and resilience in our projects, and a variety of tools that facilitate remote collaboration. We also highlight how, at a community level, we can take advantage of online communication platforms for gaining accessibility to conferences and meetings, and for maintaining research networks and community engagement while promoting a more diverse and inclusive community. Overall, we are confident that these practices can support a more inclusive and kinder scientific culture for the longer term.", "doi": "10.1002/ece3.7026", "pmid": "33898011", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "ECE37026"}, {"db": "pmc", "key": "PMC8057324"}], "notes": [], "created": "2021-04-29T10:30:06.622Z", "modified": "2021-04-29T10:31:02.408Z"}, {"entity": "publication", "iuid": "bd9a35673402475f8d9617e727313371", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bd9a35673402475f8d9617e727313371.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bd9a35673402475f8d9617e727313371"}}, "title": "Error rates in SARS-CoV-2 testing examined with Bayes' theorem.", "authors": [{"family": "Bentley", "given": "P M", "initials": "PM"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": "7", "issue": "4", "pages": "e06905", "issn-l": null}, "abstract": "The SARS-CoV-2 pandemic has created a demand for large scale testing, as part of the effort to understand and control transmission. It is important to quantify the error rates of test equipment under field conditions, which might differ significantly from those obtained in the laboratory. A literature review on SARS-CoV-2 reverse-transcription polymerase chain reaction (RT-PCR) is used to construct a clinical test confusion matrix. A simple correction method for bulk test results is then demonstrated with examples. The required sensitivity and specificity of a test are explored for societal needs and use cases, before a sequential analysis of common example scenarios is explored. The analysis suggests that many of the people with mild symptoms and positive test results are unlikely to be infected with SARS-CoV-2 in some regions. It is concluded that current and foreseen alternative tests can not be used to \"clear\" people as being non-infected. Recommendations are given that regional authorities must establish a programme to monitor operational test characteristics before launching large scale testing; and that large scale testing for tracing infection networks in some regions is not viable, but may be possible in a focused way that does not exceed the working capacity of the laboratories staffed by competent experts. RT-PCR tests can not be solely relied upon as the gold standard for SARS-CoV-2 diagnosis at scale, instead clinical assessment supported by a range of expert diagnostic tests should be used.", "doi": "10.1016/j.heliyon.2021.e06905", "pmid": "33937546", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)01008-2"}, {"db": "pmc", "key": "PMC8080131"}], "notes": [], "created": "2021-05-04T15:58:32.202Z", "modified": "2021-05-04T15:58:32.212Z"}, {"entity": "publication", "iuid": "54926588f7d343be90f590e89292ffa1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54926588f7d343be90f590e89292ffa1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54926588f7d343be90f590e89292ffa1"}}, "title": "Elevated factor V activity and antigen levels in patients with Covid\u201019 are related to disease severity and 30\u2010day mortality", "authors": [{"family": "Meijenfeldt", "given": "Fien A", "initials": "FA", "orcid": "0000-0003-0274-2414", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76b5cb67f6e243459441f06d41f0816c.json"}}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Adelmeijer", "given": "Jelle", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Thalin", "given": "Charlotte", "initials": "C"}, {"family": "Lisman", "given": "Ton", "initials": "T", "orcid": "0000-0002-3503-7140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7431e810d13c443ca5dacbf5d368e60b.json"}}], "type": "journal-article", "published": "2021-04-00", "journal": {"title": "Am J Hematol", "issn": "0361-8609", "issn-l": null, "volume": "96", "issue": "4", "pages": null}, "abstract": null, "doi": "10.1002/ajh.26085", "pmid": "33393103", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-04T16:18:01.104Z", "modified": "2021-12-12T18:06:38.589Z"}, {"entity": "publication", "iuid": "6263eec832f54ef69a97f6d3d0c37763", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6263eec832f54ef69a97f6d3d0c37763.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6263eec832f54ef69a97f6d3d0c37763"}}, "title": "Effectiveness of the Comirnaty (BNT162b2, BioNTech/Pfizer) vaccine in preventing SARS-CoV-2 infection among healthcare workers, Treviso province, Veneto region, Italy, 27 December 2020 to 24 March 2021.", "authors": [{"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Ramigni", "given": "Mauro", "initials": "M"}, {"family": "Gobbetto", "given": "Valentina", "initials": "V"}, {"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Piovesan", "given": "Cinzia", "initials": "C"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "17", "issn-l": null}, "abstract": "Data on effectiveness of the BioNTech-/Pfizer COVID-19 vaccine in real-world settings are limited. In a study of 6,423 healthcare workers in Treviso Province, Italy, we estimated that, within the time intervals of 14-21 days from the first and at least 7 days from the second dose, vaccine effectiveness in preventing SARS-CoV-2 infection was 84% (95% confidence interval (CI): 40-96) and 95% (95% CI: 62-99), respectively. These results could support the ongoing vaccination campaigns by providing evidence for targeted communication.", "doi": "10.2807/1560-7917.ES.2021.26.17.2100420", "pmid": "33928898", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-05-04T16:04:18.214Z", "modified": "2021-05-04T16:04:18.224Z"}, {"entity": "publication", "iuid": "9931c97142514ddaa8f78e17e737d5fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9931c97142514ddaa8f78e17e737d5fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9931c97142514ddaa8f78e17e737d5fd"}}, "title": "Dependence of SARS-CoV-2 infection on cholesterol-rich lipid raft and endosomal acidification", "authors": [{"family": "Li", "given": "Xiaowei", "initials": "X"}, {"family": "Zhu", "given": "Wenhua", "initials": "W"}, {"family": "Fan", "given": "Meiyang", "initials": "M"}, {"family": "Zhang", "given": "Jing", "initials": "J"}, {"family": "Peng", "given": "Yizhao", "initials": "Y"}, {"family": "Huang", "given": "Fumeng", "initials": "F"}, {"family": "Wang", "given": "Nan", "initials": "N"}, {"family": "He", "given": "Langchong", "initials": "L"}, {"family": "Zhang", "given": "Lei", "initials": "L"}, {"family": "Holmdahl", "given": "Rikard", "initials": "R"}, {"family": "Meng", "given": "Liesu", "initials": "L"}, {"family": "Lu", "given": "Shemin", "initials": "S"}], "type": "journal-article", "published": "2021-04-00", "journal": {"title": "Comput Struct Biotechnol J", "issn": "2001-0370", "issn-l": "2001-0370", "volume": null, "issue": null, "pages": null}, "abstract": "Coronavirus disease 2019 is a kind of viral pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the mechanism whereby SARS-CoV-2 invades host cells remains poorly understood. Here we used SARS-CoV-2 pseudoviruses to infect human angiotensin-converting enzyme 2 (ACE2) expressing HEK293T cells and evaluated virus infection. We confirmed that SARS-CoV-2 entry was dependent on ACE2 and sensitive to pH of endosome/lysosome in HEK293T cells. The infection of SARS-CoV-2 pseudoviruses is independent of dynamin, clathrin, caveolin and endophilin A2, as well as macropinocytosis. Instead, we found that the infection of SARS-CoV-2 pseudoviruses was cholesterol-rich lipid raft dependent. Cholesterol depletion of cell membranes with methyl-\u03b2-cyclodextrin resulted in reduction of pseudovirus infection. The infection of SARS-CoV-2 pseudoviruses resumed with cholesterol supplementation. Together, cholesterol-rich lipid rafts, and endosomal acidification, are key steps of SARS-CoV-2 required for infection of host cells. Therefore, our finding expands the understanding of SARS-CoV-2 entry mechanism and provides a new anti-SARS-CoV-2 strategy.", "doi": "10.1016/j.csbj.2021.04.001", "pmid": "33850607", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-15T10:33:48.387Z", "modified": "2021-04-21T08:55:37.850Z"}, {"entity": "publication", "iuid": "587fb02cc83e473a8da6f20bc7edafce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/587fb02cc83e473a8da6f20bc7edafce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/587fb02cc83e473a8da6f20bc7edafce"}}, "title": "Cloth Masks May Prevent Transmission of COVID-19", "authors": [{"family": "Clase", "given": "Catherine M", "initials": "CM"}, {"family": "Fu", "given": "Edouard L", "initials": "EL"}, {"family": "Jardine", "given": "Meg", "initials": "M"}, {"family": "Mann", "given": "Johannes F E", "initials": "JFE"}, {"family": "Carrero", "given": "Juan J", "initials": "JJ"}], "type": "journal-article", "published": "2021-04-00", "journal": {"title": "Ann Intern Med", "issn": "0003-4819", "volume": "174", "issue": "4", "pages": "580", "issn-l": null}, "abstract": null, "doi": "10.7326/l21-0091", "pmid": null, "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-04-20T17:52:54.999Z", "modified": "2021-04-20T17:52:55.012Z"}, {"entity": "publication", "iuid": "d5a7eec396b04e21a41f59382f5a79ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5a7eec396b04e21a41f59382f5a79ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5a7eec396b04e21a41f59382f5a79ee"}}, "title": "Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021.", "authors": [{"family": "Funk", "given": "Tjede", "initials": "T"}, {"family": "Pharris", "given": "Anastasia", "initials": "A"}, {"family": "Spiteri", "given": "Gianfranco", "initials": "G"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "Carr", "given": "Michael", "initials": "M"}, {"family": "Gonzalez", "given": "Gabriel", "initials": "G"}, {"family": "Garcia-Leon", "given": "Alejandro", "initials": "A"}, {"family": "Crispie", "given": "Fiona", "initials": "F"}, {"family": "O'Connor", "given": "Lois", "initials": "L"}, {"family": "Murphy", "given": "Niamh", "initials": "N"}, {"family": "Mossong", "given": "Jo\u00ebl", "initials": "J"}, {"family": "Vergison", "given": "Anne", "initials": "A"}, {"family": "Wienecke-Baldacchino", "given": "Anke K", "initials": "AK"}, {"family": "Abdelrahman", "given": "Tamir", "initials": "T"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Di Martino", "given": "Angela", "initials": "A"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Lo Presti", "given": "Alessandra", "initials": "A"}, {"family": "Casaca", "given": "Pedro", "initials": "P"}, {"family": "Moreno", "given": "Joana", "initials": "J"}, {"family": "Borges", "given": "V\u00edtor", "initials": "V"}, {"family": "Isidro", "given": "Joana", "initials": "J"}, {"family": "Ferreira", "given": "Rita", "initials": "R"}, {"family": "Gomes", "given": "Jo\u00e3o Paulo", "initials": "JP"}, {"family": "Dotsenko", "given": "Liidia", "initials": "L"}, {"family": "Suija", "given": "Heleene", "initials": "H"}, {"family": "Epstein", "given": "Jevgenia", "initials": "J"}, {"family": "Sadikova", "given": "Olga", "initials": "O"}, {"family": "Sepp", "given": "Hanna", "initials": "H"}, {"family": "Ikonen", "given": "Niina", "initials": "N"}, {"family": "Savolainen-Kopra", "given": "Carita", "initials": "C"}, {"family": "Blomqvist", "given": "Soile", "initials": "S"}, {"family": "M\u00f6tt\u00f6nen", "given": "Teemu", "initials": "T"}, {"family": "Helve", "given": "Otto", "initials": "O"}, {"family": "Gomes-Dias", "given": "Joana", "initials": "J"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "COVID study groups", "given": "", "initials": ""}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "16", "issn-l": null}, "abstract": "We compared 19,207 cases of SARS-CoV-2 variant B.1.1.7/S gene target failure (SGTF), 436 B.1.351 and 352 P.1 to non-variant cases reported by seven European countries. COVID-19 cases with these variants had significantly higher adjusted odds ratios for hospitalisation (B.1.1.7/SGTF: 1.7, 95% confidence interval (CI): 1.0-2.9; B.1.351: 3.6, 95% CI: 2.1-6.2; P.1: 2.6, 95% CI: 1.4-4.8) and B.1.1.7/SGTF and P.1 cases also for intensive care admission (B.1.1.7/SGTF: 2.3, 95% CI: 1.4-3.5; P.1: 2.2, 95% CI: 1.7-2.8).", "doi": "10.2807/1560-7917.ES.2021.26.16.2100348", "pmid": "33890566", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "URL", "key": "https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2021.26.16.2100348", "description": "All data is included in the supplementary material"}], "notes": [], "created": "2021-04-29T15:38:29.078Z", "modified": "2021-11-18T12:55:13.856Z"}, {"entity": "publication", "iuid": "f80c158699b2466c9ef82f8f15e35e63", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f80c158699b2466c9ef82f8f15e35e63.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f80c158699b2466c9ef82f8f15e35e63"}}, "title": "Attributes and predictors of long COVID.", "authors": [{"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Murray", "given": "Benjamin", "initials": "B", "orcid": "0000-0002-2413-923X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebec738df0224bf4874fd6c08fd23fae.json"}}, {"family": "Varsavsky", "given": "Thomas", "initials": "T"}, {"family": "Graham", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-4170-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f5f4e19812a46ed9e873732ec25e28d.json"}}, {"family": "Penfold", "given": "Rose S", "initials": "RS"}, {"family": "Bowyer", "given": "Ruth C", "initials": "RC", "orcid": "0000-0002-6941-8160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eebaf361c184499ca6729aa60cc0af3d.json"}}, {"family": "Pujol", "given": "Joan Capdevila", "initials": "JC", "orcid": "0000-0003-1658-1076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60965a027a4b4d048728748f09c98594.json"}}, {"family": "Klaser", "given": "Kerstin", "initials": "K"}, {"family": "Antonelli", "given": "Michela", "initials": "M"}, {"family": "Canas", "given": "Liane S", "initials": "LS"}, {"family": "Molteni", "given": "Erika", "initials": "E", "orcid": "0000-0001-7773-8140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9aed1fbe444b48d4bfacb12050953c8e.json"}}, {"family": "Modat", "given": "Marc", "initials": "M"}, {"family": "Jorge Cardoso", "given": "M", "initials": "M", "orcid": "0000-0003-1284-2558", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0ed3abec67644e186650e1d1dcbbe0b.json"}}, {"family": "May", "given": "Anna", "initials": "A"}, {"family": "Ganesh", "given": "Sajaysurya", "initials": "S", "orcid": "0000-0002-3720-4176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6dbf91180806442082ce6732c1b75923.json"}}, {"family": "Davies", "given": "Richard", "initials": "R", "orcid": "0000-0003-2050-3994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b82cc92615f462d9af0153a6fb94fde.json"}}, {"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Drew", "given": "David A", "initials": "DA", "orcid": "0000-0002-8813-0816", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd3a2cffdc104f18b8684cf4f27d68b2.json"}}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Merino", "given": "Jordi", "initials": "J", "orcid": "0000-0001-8312-1438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12ab049914a542b39affcfb4196861d2.json"}}, {"family": "Tsereteli", "given": "Neli", "initials": "N"}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f34c0d3602439abe6096293c7c732d.json"}}, {"family": "Gomez", "given": "Maria F", "initials": "MF", "orcid": "0000-0001-6210-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e09e37219c4f42c8a7b3a982da523859.json"}}, {"family": "Duncan", "given": "Emma L", "initials": "EL"}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874802ae65824a90ba50eabdeabb8356.json"}}, {"family": "Williams", "given": "Frances M K", "initials": "FMK", "orcid": "0000-0002-2998-2744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87a6db988c2e421f81fce7773436aefa.json"}}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74cf1f7094744ee289fa5df041e7cb5b.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-7284-6767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeefbf47fd384d5390109fe1a903bd18.json"}}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Ourselin", "given": "Sebastien", "initials": "S", "orcid": "0000-0002-5694-5340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74c7b9b1633144879042d198c7205656.json"}}, {"family": "Spector", "given": "Tim", "initials": "T", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956", "volume": "27", "issue": "4", "pages": "626-631"}, "abstract": "Reports of long-lasting coronavirus disease 2019 (COVID-19) symptoms, the so-called 'long COVID', are rising but little is known about prevalence, risk factors or whether it is possible to predict a protracted course early in the disease. We analyzed data from 4,182 incident cases of COVID-19 in which individuals self-reported their symptoms prospectively in the COVID Symptom Study app1. A total of 558 (13.3%) participants reported symptoms lasting \u226528 days, 189 (4.5%) for \u22658 weeks and 95 (2.3%) for \u226512 weeks. Long COVID was characterized by symptoms of fatigue, headache, dyspnea and anosmia and was more likely with increasing age and body mass index and female sex. Experiencing more than five symptoms during the first week of illness was associated with long COVID (odds ratio = 3.53 (2.76-4.50)). A simple model to distinguish between short COVID and long COVID at 7 days (total sample size, n = 2,149) showed an area under the curve of the receiver operating characteristic curve of 76%, with replication in an independent sample of 2,472 individuals who were positive for severe acute respiratory syndrome coronavirus 2. This model could be used to identify individuals at risk of long COVID for trials of prevention or treatment and to plan education and rehabilitation services.", "doi": "10.1038/s41591-021-01292-y", "pmid": "33692530", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "mid", "key": "EMS131037"}, {"db": "pmc", "key": "PMC7611399"}, {"db": "pii", "key": "10.1038/s41591-021-01292-y"}], "notes": [], "created": "2021-01-07T16:47:03.626Z", "modified": "2023-06-19T15:07:13.510Z"}, {"entity": "publication", "iuid": "3a7826632dde417d8a75ee0117438d85", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a7826632dde417d8a75ee0117438d85.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a7826632dde417d8a75ee0117438d85"}}, "title": "Assessing mandatory stay-at-home and business closure effects on the spread of COVID-19.", "authors": [{"family": "Bendavid", "given": "Eran", "initials": "E", "orcid": "0000-0002-8364-4711", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79b88b45b7634279bdcb7b3629caae9f.json"}}, {"family": "Oh", "given": "Christopher", "initials": "C"}, {"family": "Bhattacharya", "given": "Jay", "initials": "J", "orcid": "0000-0003-3867-3174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12aad76bb20d4b29b500b194f3e84d17.json"}}, {"family": "Ioannidis", "given": "John P A", "initials": "JPA", "orcid": "0000-0003-3118-6859", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9844ea41bc554157a721820d7986a442.json"}}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Eur J Clin Invest", "issn": "1365-2362", "volume": "51", "issue": "4", "pages": "e13484", "issn-l": null}, "abstract": "The most restrictive nonpharmaceutical interventions (NPIs) for controlling the spread of COVID-19 are mandatory stay-at-home and business closures. Given the consequences of these policies, it is important to assess their effects. We evaluate the effects on epidemic case growth of more restrictive NPIs (mrNPIs), above and beyond those of less-restrictive NPIs (lrNPIs).\n\nWe first estimate COVID-19 case growth in relation to any NPI implementation in subnational regions of 10 countries: England, France, Germany, Iran, Italy, Netherlands, Spain, South Korea, Sweden and the United States. Using first-difference models with fixed effects, we isolate the effects of mrNPIs by subtracting the combined effects of lrNPIs and epidemic dynamics from all NPIs. We use case growth in Sweden and South Korea, 2 countries that did not implement mandatory stay-at-home and business closures, as comparison countries for the other 8 countries (16 total comparisons).\n\nImplementing any NPIs was associated with significant reductions in case growth in 9 out of 10 study countries, including South Korea and Sweden that implemented only lrNPIs (Spain had a nonsignificant effect). After subtracting the epidemic and lrNPI effects, we find no clear, significant beneficial effect of mrNPIs on case growth in any country. In France, for example, the effect of mrNPIs was +7% (95% CI: -5%-19%) when compared with Sweden and + 13% (-12%-38%) when compared with South Korea (positive means pro-contagion). The 95% confidence intervals excluded 30% declines in all 16 comparisons and 15% declines in 11/16 comparisons.\n\nWhile small benefits cannot be excluded, we do not find significant benefits on case growth of more restrictive NPIs. Similar reductions in case growth may be achievable with less-restrictive interventions.", "doi": "10.1111/eci.13484", "pmid": "33400268", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7883103"}], "notes": [], "created": "2023-01-13T13:30:03.001Z", "modified": "2023-01-13T13:30:03.092Z"}, {"entity": "publication", "iuid": "cbb613cf35da41c8be1815197e30108d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cbb613cf35da41c8be1815197e30108d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cbb613cf35da41c8be1815197e30108d"}}, "title": "SARS-CoV-2 infection incidence during the first and second COVID-19 waves in Italy.", "authors": [{"family": "Vinceti", "given": "Marco", "initials": "M"}, {"family": "Filippini", "given": "Tommaso", "initials": "T"}, {"family": "Rothman", "given": "Kenneth J", "initials": "KJ"}, {"family": "Di Federico", "given": "Silvia", "initials": "S"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}], "type": "journal article", "published": "2021-03-31", "journal": {"title": "Environ Res", "issn": "1096-0953", "volume": null, "issue": null, "pages": "111097", "issn-l": "0013-9351"}, "abstract": "We assessed the relation between Covid-19 waves in Italy, which was severely affected during the pandemic. We evaluated the hypothesis that a larger impact from the first wave (February-March 2020) predicts a smaller peak during the second wave (September-October), in the absence of local changes in public health interventions and area-specific differences in time trends of environmental parameters. Based on publicly available data on province-specific SARS-CoV-2 infections and both crude and multivariable cubic spline regression models, we found that for provinces with the lowest incidence rates in the first wave, the incidence in the second wave increased roughly in proportion with the incidence in the first wave until an incidence of about 500-600 cases/100,000 in the first wave. Above that value, provinces with higher incidences in the first wave experienced lower incidences in the second wave. It appears that a comparatively high cumulative incidence of infection, even if far below theoretical thresholds required for herd immunity, may provide noticeable protection during the second wave. We speculate that, if real, the mechanism for this pattern could be depletion of most susceptible individuals and of superspreaders in the first wave. A population learning effect regarding cautious behavior could have also contributed. Since no area-specific variation of the national policy against the SARS-CoV-2 outbreak was allowed until early November 2020, neither individual behaviours nor established or purported environmental risk factors of Covid-19, such as air pollution and meteorological factors, are likely to have confounded the inverse trends we observed in infection incidence over time.", "doi": "10.1016/j.envres.2021.111097", "pmid": "33811866", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0013-9351(21)00391-1"}], "notes": [], "created": "2021-04-06T10:11:10.599Z", "modified": "2021-04-06T10:11:10.610Z"}, {"entity": "publication", "iuid": "9951948df6af47d19567e1e5335019c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9951948df6af47d19567e1e5335019c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9951948df6af47d19567e1e5335019c5"}}, "title": "Report from the CVOT Summit 2020: new cardiovascular and renal outcomes.", "authors": [{"family": "Schnell", "given": "Oliver", "initials": "O"}, {"family": "Cos", "given": "Xavier", "initials": "X"}, {"family": "Cosentino", "given": "Francesco", "initials": "F"}, {"family": "Forst", "given": "Thomas", "initials": "T"}, {"family": "Giorgino", "given": "Francesco", "initials": "F"}, {"family": "Heersprink", "given": "Hiddo J L", "initials": "HJL"}, {"family": "Kosiborod", "given": "Mikhail", "initials": "M"}, {"family": "Wanner", "given": "Christoph", "initials": "C"}, {"family": "Standl", "given": "Eberhard", "initials": "E"}], "type": "editorial", "published": "2021-03-31", "journal": {"title": "Cardiovasc Diabetol", "issn": "1475-2840", "volume": "20", "issue": "1", "pages": "75", "issn-l": null}, "abstract": "The 6th Cardiovascular Outcome Trial (CVOT) Summit \"Cardiovascular and Renal Outcomes 2020\" was the first to be held virtually on October 29-30, 2020. As in previous years, this summit served as reference meeting for in-depth discussions on the topic of recently completed and presented major outcome trials. This year, focus was placed on the outcomes of VERTIS-CV, EMPEROR-Reduced, DAPA-CKD, and FIDELIO-DKD. Trial implications for diabetes management and the impact on new treatment algorithms were highlighted for diabetologists, cardiologists, endocrinologists, nephrologists, and general practitioners. Discussion evolved from major outcome trials using SGLT-2 inhibitors for treatment and prevention of heart failure and chronic kidney disease in people with and without diabetes, to additional therapy options for chronic kidney disease with a novel mineralocorticoid receptor antagonist. Furthermore, challenges in diabetes management like COVID-19 and obesity, as well as novel treatment strategies and guidelines, were discussed.The 7th Cardiovascular Outcome Trial Summit will be held virtually on November, 18-19, 2021 ( http://www.cvot.org ).", "doi": "10.1186/s12933-021-01254-1", "pmid": "33789663", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12933-021-01254-1"}, {"db": "pmc", "key": "PMC8010779"}], "notes": [], "created": "2021-04-06T10:39:05.268Z", "modified": "2021-04-06T10:39:05.290Z"}, {"entity": "publication", "iuid": "a0636447716b4b328bbc5bd67a94da12", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a0636447716b4b328bbc5bd67a94da12.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a0636447716b4b328bbc5bd67a94da12"}}, "title": "Immunotherapy may protect cancer patients from SARS-CoV-2 infection: a single-center retrospective analysis.", "authors": [{"family": "Isgr\u00f2", "given": "Maria Antonietta", "initials": "MA"}, {"family": "Vitale", "given": "Maria Grazia", "initials": "MG"}, {"family": "Celentano", "given": "Egidio", "initials": "E"}, {"family": "Nocerino", "given": "Flavia", "initials": "F"}, {"family": "Porciello", "given": "Giuseppe", "initials": "G"}, {"family": "Curvietto", "given": "Marcello", "initials": "M"}, {"family": "Mallardo", "given": "Domenico", "initials": "D"}, {"family": "Montagnese", "given": "Concetta", "initials": "C"}, {"family": "Russo", "given": "Luigi", "initials": "L"}, {"family": "Zanaletti", "given": "Nicoletta", "initials": "N"}, {"family": "Avallone", "given": "Antonio", "initials": "A"}, {"family": "Pensabene", "given": "Matilde", "initials": "M"}, {"family": "De Laurentiis", "given": "Michelino", "initials": "M"}, {"family": "Centonze", "given": "Sara", "initials": "S"}, {"family": "Pignata", "given": "Sandro", "initials": "S"}, {"family": "Cannella", "given": "Lucia", "initials": "L"}, {"family": "Morabito", "given": "Alessandro", "initials": "A"}, {"family": "Caponigro", "given": "Francesco", "initials": "F"}, {"family": "Botti", "given": "Gerardo", "initials": "G"}, {"family": "Masucci", "given": "Giuseppe Valentino", "initials": "GV"}, {"family": "Giannarelli", "given": "Diana", "initials": "D"}, {"family": "Cavalcanti", "given": "Ernesta", "initials": "E"}, {"family": "Ascierto", "given": "Paolo Antonio", "initials": "PA"}], "type": "journal article", "published": "2021-03-31", "journal": {"title": "J Transl Med", "issn": "1479-5876", "volume": "19", "issue": "1", "pages": "132", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) global pandemic has created unique challenges to healthcare systems throughout the world. Ensuring subjects' safety is mandatory especially in oncology, in consideration of cancer patients' particular frailty. We examined the proportion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgM and/or IgG positive subjects in three different groups from Istituto Nazionale Tumori - IRCCS \"Fondazione G. Pascale\" in Naples (Campania region, Italy): cancer patients treated with Innovative Immunotherapy (Immune Checkpoint Inhibitors, ICIs), cancer patients undergoing standard Chemotherapies (CHTs) and healthcare providers. 9 out of 287 (3.1%) ICIs patients resulted positive, with a significant lower percentage in respect to CHTs patients (39 positive subjects out of 598, 6.5%) (p = 0.04). There was no statistically significant difference between ICIs cohort and healthcare providers, 48 out of 1050 resulting positive (4.6%). Performing a Propensity Score Matching based on gender and tumor stage, the effect of treatment on seropositivity was analyzed through a regression logistic model and the ICIs treatment resulted to be the only protective factor significantly (p = 0.03) associated with positivity (odds ratio-OR: 0.41; 95% confidence interval-CI 0.18-0.91). According to these preliminary data, ICIs would appear to be a protective factor against the onset of COVID-19 infection.", "doi": "10.1186/s12967-021-02798-2", "pmid": "33789686", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12967-021-02798-2"}, {"db": "pmc", "key": "PMC8010485"}], "notes": [], "created": "2021-04-06T10:44:34.189Z", "modified": "2021-04-06T10:45:15.550Z"}, {"entity": "publication", "iuid": "bc41bcd6a843474c8beee260d5a0ed27", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bc41bcd6a843474c8beee260d5a0ed27.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bc41bcd6a843474c8beee260d5a0ed27"}}, "title": "Household food insecurity and its association with self-reported male perpetration of intimate partner violence: a survey of two districts in central and western Uganda.", "authors": [{"family": "Awungafac", "given": "George", "initials": "G"}, {"family": "Mugamba", "given": "Stephen", "initials": "S"}, {"family": "Nalugoda", "given": "Fred", "initials": "F"}, {"family": "Sj\u00f6land", "given": "Carl Fredrik", "initials": "CF"}, {"family": "Kigozi", "given": "Godfrey", "initials": "G"}, {"family": "Rautiainen", "given": "Susanne", "initials": "S"}, {"family": "Malyabe", "given": "Robert Bulamba", "initials": "RB"}, {"family": "Ziegel", "given": "Leo", "initials": "L"}, {"family": "Nakigozi", "given": "Gertrude", "initials": "G"}, {"family": "Nalwoga", "given": "Grace Kigozi", "initials": "GK"}, {"family": "Kyasanku", "given": "Emmanuel", "initials": "E"}, {"family": "Nkale", "given": "James", "initials": "J"}, {"family": "Watya", "given": "Stephen", "initials": "S"}, {"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM"}, {"family": "K\u00e5gesten", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-03-31", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "3", "pages": "e045427"}, "abstract": "This study aimed to determine the lifetime prevalence of male-perpetrated intimate partner violence (IPV), and to assess the association with food insecurity, sociodemographic factors and health risk behaviours in Uganda in the year preceding COVID-19-associated lockdowns.\r\n\r\nPopulation-based, cross-sectional household survey.\r\n\r\nUrban, semiurban and rural communities of the Wakiso and Hoima districts in Uganda.\r\n\r\nA total of N=2014 males aged 13-80 years participated in the survey. The current study included males who reported having ever been in a sexual union and responded to the IPV questions (N=1314).\r\n\r\nData were collected face-to-face from May 2018 to July 2019 using an interviewer-mediated questionnaire. Lifetime IPV perpetration was measured as 'no physical and/or sexual IPV', 'physical' versus 'sexual violence only', and 'physical and sexual violence'. Past-year food insecurity was measured through the Food Insecurity Experience Scale and categorised into 'none', 'low' and 'high'. Multinomial logistic regression was used to determine the crude and adjusted relative risk ratios (aRRRs) of IPV perpetration in relation to self-reported food insecurity, adjusting for sociodemographic and health risk behaviours.\r\n\r\nThe prevalence of self-reported lifetime IPV perpetration was 14.6% for physical and 6.5% for sexual violence, while 5.3% reported to have perpetrated both physical and sexual IPV. Most (75.7%) males reported no food insecurity, followed by low (20.7%) and high (3.6%) food insecurity. In adjusted models, food insecurity was associated with increased risk of having perpetrated both physical and sexual violence (aRRR=2.57, 95% CI 1.52 to 4.32). IPV perpetration was also independently associated with having had more than one lifetime sexual partner and drinking alcohol, but not with education level or religion.\r\n\r\nThis study suggests that food insecurity is associated with male IPV perpetration, and more efforts are needed to prevent and mitigate the expected worsening of this situation as a result of the COVID-19 pandemic.", "doi": "10.1136/bmjopen-2020-045427", "pmid": "33789856", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-045427"}], "notes": [], "created": "2021-04-06T10:43:45.278Z", "modified": "2021-06-18T15:49:13.890Z"}, {"entity": "publication", "iuid": "b1cbf1dcbb51410d9addeac7af4e00a3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1cbf1dcbb51410d9addeac7af4e00a3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1cbf1dcbb51410d9addeac7af4e00a3"}}, "title": "A longitudinal assessment of depression and anxiety in the Republic of Ireland before and during the COVID-19 pandemic.", "authors": [{"family": "Hyland", "given": "Philip", "initials": "P"}, {"family": "Shevlin", "given": "Mark", "initials": "M"}, {"family": "Murphy", "given": "Jamie", "initials": "J"}, {"family": "McBride", "given": "Orla", "initials": "O"}, {"family": "Fox", "given": "Robert", "initials": "R"}, {"family": "Bondjers", "given": "Kristina", "initials": "K"}, {"family": "Karatzias", "given": "Thanos", "initials": "T"}, {"family": "Bentall", "given": "Richard P", "initials": "RP"}, {"family": "Martinez", "given": "Anton", "initials": "A"}, {"family": "Valli\u00e8res", "given": "Fr\u00e9d\u00e9rique", "initials": "F"}], "type": "journal article", "published": "2021-03-31", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "issn-l": null, "volume": "300", "issue": null, "pages": "113905"}, "abstract": "Few studies have examined changes in mental health before and after the outbreak of COVID-19. We examined changes in the prevalence of major depression and generalized anxiety disorder (GAD) between February 2019 and March-April 2020; if there were changes in major depression and GAD during six weeks of nationwide lockdown; and we identified factors that predicted major depression and GAD across the six-week lockdown period. Nationally representative samples of Irish adults were gathered using identical methods in February 2019 (N = 1020) and March-April 2020 (N = 1041). The latter was reassessed six weeks later. Significantly more people screened positive for depression in February 2019 (29.8% 95% CI = 27.0, 32.6) than in March-April 2020 (22.8% 95% CI = 20.2, 25.3), and there was no change in GAD. There were no significant changes in depression and GAD during the lockdown. Major depression was predicted by younger age, non-city dwelling, lower resilience, higher loneliness, and higher somatic problems. GAD was predicted by a broader set of variables including several COVID-19 specific variables. These findings indicate that the prevalence of major depression and GAD did not increase as a result of, or during the early phase of the COVID-19 pandemic in Ireland.", "doi": "10.1016/j.psychres.2021.113905", "pmid": "33827013", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(21)00202-X"}], "notes": [], "created": "2021-04-09T16:39:06.688Z", "modified": "2021-06-18T15:49:45.988Z"}, {"entity": "publication", "iuid": "6ed7d515b54b4351a8752f9debe15ad5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ed7d515b54b4351a8752f9debe15ad5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ed7d515b54b4351a8752f9debe15ad5"}}, "title": "Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials.", "authors": [{"family": "Jolliffe", "given": "David A", "initials": "DA"}, {"family": "Camargo", "given": "Carlos A", "initials": "CA"}, {"family": "Sluyter", "given": "John D", "initials": "JD"}, {"family": "Aglipay", "given": "Mary", "initials": "M"}, {"family": "Aloia", "given": "John F", "initials": "JF"}, {"family": "Ganmaa", "given": "Davaasambuu", "initials": "D"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Bischoff-Ferrari", "given": "Heike A", "initials": "HA"}, {"family": "Borzutzky", "given": "Arturo", "initials": "A"}, {"family": "Damsgaard", "given": "Camilla T", "initials": "CT"}, {"family": "Dubnov-Raz", "given": "Gal", "initials": "G"}, {"family": "Esposito", "given": "Susanna", "initials": "S"}, {"family": "Gilham", "given": "Clare", "initials": "C"}, {"family": "Ginde", "given": "Adit A", "initials": "AA"}, {"family": "Golan-Tripto", "given": "Inbal", "initials": "I"}, {"family": "Goodall", "given": "Emma C", "initials": "EC"}, {"family": "Grant", "given": "Cameron C", "initials": "CC"}, {"family": "Griffiths", "given": "Christopher J", "initials": "CJ"}, {"family": "Hibbs", "given": "Anna Maria", "initials": "AM"}, {"family": "Janssens", "given": "Wim", "initials": "W"}, {"family": "Khadilkar", "given": "Anuradha Vaman", "initials": "AV"}, {"family": "Laaksi", "given": "Ilkka", "initials": "I"}, {"family": "Lee", "given": "Margaret T", "initials": "MT"}, {"family": "Loeb", "given": "Mark", "initials": "M"}, {"family": "Maguire", "given": "Jonathon L", "initials": "JL"}, {"family": "Majak", "given": "Pawe\u0142", "initials": "P"}, {"family": "Mauger", "given": "David T", "initials": "DT"}, {"family": "Manaseki-Holland", "given": "Semira", "initials": "S"}, {"family": "Murdoch", "given": "David R", "initials": "DR"}, {"family": "Nakashima", "given": "Akio", "initials": "A"}, {"family": "Neale", "given": "Rachel E", "initials": "RE"}, {"family": "Pham", "given": "Hai", "initials": "H"}, {"family": "Rake", "given": "Christine", "initials": "C"}, {"family": "Rees", "given": "Judy R", "initials": "JR"}, {"family": "Rosendahl", "given": "Jenni", "initials": "J"}, {"family": "Scragg", "given": "Robert", "initials": "R"}, {"family": "Shah", "given": "Dheeraj", "initials": "D"}, {"family": "Shimizu", "given": "Yoshiki", "initials": "Y"}, {"family": "Simpson-Yap", "given": "Steve", "initials": "S"}, {"family": "Trilok-Kumar", "given": "Geeta", "initials": "G"}, {"family": "Urashima", "given": "Mitsuyoshi", "initials": "M"}, {"family": "Martineau", "given": "Adrian R", "initials": "AR"}], "type": "journal article", "published": "2021-03-30", "journal": {"title": "Lancet Diabetes Endocrinol", "issn": "2213-8595", "volume": null, "issue": null, "issn-l": null}, "abstract": "A 2017 meta-analysis of data from 25 randomised controlled trials (RCTs) of vitamin D supplementation for the prevention of acute respiratory infections (ARIs) revealed a protective effect of this intervention. We aimed to examine the link between vitamin D supplementation and prevention of ARIs in an updated meta-analysis.\n\nFor this systematic review and meta-analysis, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, and the ClinicalTrials.gov registry for studies listed from database inception to May 1, 2020. Double-blind RCTs of vitamin D 3, vitamin D2, or 25-hydroxyvitamin D (25[OH]D) supplementation for any duration, with a placebo or low-dose vitamin D control, were eligible if they had been approved by a research ethics committee, and if ARI incidence was collected prospectively and prespecified as an efficacy outcome. Studies reporting results of long-term follow-up of primary RCTs were excluded. Aggregated study-level data, stratified by baseline 25(OH)D concentration and age, were obtained from study authors. Using the proportion of participants in each trial who had one or more ARIs, we did a random-effects meta-analysis to obtain pooled odds ratios (ORs) and 95% CIs to estimate the effect of vitamin D supplementation on the risk of having one or more ARIs (primary outcome) compared with placebo. Subgroup analyses were done to estimate whether the effects of vitamin D supplementation on the risk of ARI varied according to baseline 25(OH)D concentration (<25 nmol/L vs 25\u00b70-49\u00b79 nmol/L vs 50\u00b70-74\u00b79 nmol/L vs >75\u00b70 nmol/L), vitamin D dose (daily equivalent of <400 international units [IU] vs 400-1000 IU vs 1001-2000 IU vs >2000 IU), dosing frequency (daily vs weekly vs once per month to once every 3 months), trial duration (\u226412 months vs >12 months), age at enrolment (<1\u00b700 years vs 1\u00b700-15\u00b799 years vs 16\u00b700-64\u00b799 years vs \u226565\u00b700 years), and presence versus absence of airway disease (ie, asthma only, COPD only, or unrestricted). Risk of bias was assessed with the Cochrane Collaboration Risk of Bias Tool. The study was registered with PROSPERO, CRD42020190633.\n\nWe identified 1528 articles, of which 46 RCTs (75 541 participants) were eligible. Data for the primary outcome were obtained for 48 488 (98\u00b71%) of 49 419 participants (aged 0-95 years) in 43 studies. A significantly lower proportion of participants in the vitamin D supplementation group had one or more ARIs (14 332 [61\u00b73%] of 23 364 participants) than in the placebo group (14 217 [62\u00b73%] of 22 802 participants), with an OR of 0\u00b792 (95% CI 0\u00b786-0\u00b799; 37 studies; I 2=35\u00b76%, pheterogeneity=0\u00b7018). No significant effect of vitamin D supplementation on the risk of having one or more ARIs was observed for any of the subgroups defined by baseline 25(OH)D concentration. However, protective effects of supplementation were observed in trials in which vitamin D was given in a daily dosing regimen (OR 0\u00b778 [95% CI 0\u00b765-0\u00b794]; 19 studies; I2=53\u00b75%, pheterogeneity=0\u00b7003), at daily dose equivalents of 400-1000 IU (0\u00b770 [0\u00b755-0\u00b789]; ten studies; I2=31\u00b72%, pheterogeneity=0\u00b716), for a duration of 12 months or less (0\u00b782 [0\u00b772-0\u00b793]; 29 studies; I2=38\u00b71%, pheterogeneity=0\u00b7021), and to participants aged 1\u00b700-15\u00b799 years at enrolment (0\u00b771 [0\u00b757-0\u00b790]; 15 studies; I2=46\u00b70%, pheterogeneity=0\u00b7027). No significant interaction between allocation to the vitamin D supplementation group versus the placebo group and dose, dose frequency, study duration, or age was observed. In addition, no significant difference in the proportion of participants who had at least one serious adverse event in the vitamin supplementation group compared with the placebo group was observed (0\u00b797 [0\u00b786-1\u00b707]; 36 studies; I2=0\u00b70%, pheterogeneity=0\u00b799). Risk of bias within individual studies was assessed as being low for all but three trials.\n\nDespite evidence of significant heterogeneity across trials, vitamin D supplementation was safe and overall reduced the risk of ARI compared with placebo, although the risk reduction was small. Protection was associated with administration of daily doses of 400-1000 IU for up to 12 months, and age at enrolment of 1\u00b700-15\u00b799 years. The relevance of these findings to COVID-19 is not known and requires further investigation.\n\nNone.", "doi": "10.1016/S2213-8587(21)00051-6", "pmid": "33798465", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2213-8587(21)00051-6"}], "notes": [], "created": "2021-04-06T10:40:59.319Z", "modified": "2021-04-06T10:40:59.341Z"}, {"entity": "publication", "iuid": "126cbe8fde8b4bebad2bee9b574f9e12", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/126cbe8fde8b4bebad2bee9b574f9e12.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/126cbe8fde8b4bebad2bee9b574f9e12"}}, "title": "The impact of viremia on organ failure, biomarkers and mortality in a Swedish cohort of critically ill COVID-19 patients.", "authors": [{"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Bergqvist", "given": "Anders", "initials": "A"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}], "type": "journal article", "published": "2021-03-30", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "7163"}, "abstract": "The spread of virus via the blood stream has been suggested to contribute to extra-pulmonary organ failure in Coronavirus disease 2019 (COVID-19). We assessed SARS-CoV-2 RNAemia (RNAemia) and the association between RNAemia and inflammation, organ failure and mortality in critically ill COVID-19 patients. We included all patients with PCR verified COVID-19 and consent admitted to ICU. SARS-CoV-2 RNA copies above 1000/ml measured by PCR in plasma was defined as RNAemia and used as surrogate for viremia. In this cohort of 92 patients 59 (64%) were invasively ventilated. RNAemia was found in 31 patients (34%). Hypertension and corticosteroid treatment was more common in patients with RNAemia. Extra-pulmonary organ failure biomarkers and the extent of organ failure were similar in patients with and without RNAemia, but the former group had more renal replacement therapy and higher mortality (26 vs 16%; 35 vs 16%, respectively, p = 0.04). RNAemia was not an independent predictor of death at 30 days after adjustment for age. SARS-CoV2 RNA copies in plasma is a common finding in ICU patients with COVID-19. Although viremia was not associated with extra pulmonary organ failure it was more common in patients who did not survive to 30 days after ICU admission.Trial registration: ClinicalTrials NCT04316884.", "doi": "10.1038/s41598-021-86500-y", "pmid": "33785784", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-86500-y"}, {"db": "pmc", "key": "PMC8010103"}, {"db": "ClinicalTrials.gov", "key": "NCT04316884"}], "notes": [], "created": "2021-04-09T16:26:36.852Z", "modified": "2021-06-11T14:14:53.671Z"}, {"entity": "publication", "iuid": "41e5af559a954cca92916b7c5903d08f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41e5af559a954cca92916b7c5903d08f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41e5af559a954cca92916b7c5903d08f"}}, "title": "Digital social entrepreneurship: the N-Helix response to stakeholders' COVID-19 needs.", "authors": [{"family": "Ib\u00e1\u00f1ez", "given": "Mar\u00eda J", "initials": "MJ"}, {"family": "Guerrero", "given": "Maribel", "initials": "M"}, {"family": "Y\u00e1\u00f1ez-Vald\u00e9s", "given": "Claudia", "initials": "C"}, {"family": "Barros-Celume", "given": "Sebasti\u00e1n", "initials": "S"}], "type": "journal article", "published": "2021-03-30", "journal": {"title": "J Technol Transf", "issn": "0892-9912", "volume": null, "issue": null, "pages": "1-24", "issn-l": null}, "abstract": "This study explores the emergence of a new entrepreneurship phenomenon (digital social entrepreneurship) as a result of the collaboration among many agents (N-Helix), given the government's limited capacity to respond to the stakeholders' needs satisfaction related to an exogenous event (e.g., the COVID-19 pandemic). Our theory development is based on three ongoing academic debates related to (a) the unrepresentativeness of the stakeholder theory in entrepreneurship research; (b) the emergence of digital social entrepreneurship (DSE) as a bridge between stakeholders' needs, socio-economic actors, and digital-social initiatives; and (c) the role of N-Helix collaborations to facilitate the emergence of global knowledge-intensive initiatives and the rapid adoptions of open innovations. Our results support our assumptions about the positive mediation effect of DSE in the relationship between N-Helix collaborations and stakeholders' satisfaction. Notably, results show how pandemic has intensified these relationships and how DSE in N-Helix collaborations can generate social impacts globally. Some implications for policy-makers have emerged from our results that should be considered during/post-COVID-19 pandemic.", "doi": "10.1007/s10961-021-09855-4", "pmid": "33814697", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "9855"}, {"db": "pmc", "key": "PMC8007451"}], "notes": [], "created": "2021-04-06T10:05:31.670Z", "modified": "2021-04-06T10:05:31.694Z"}, {"entity": "publication", "iuid": "23537200a18d4363813fcb1d9bc99ad4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23537200a18d4363813fcb1d9bc99ad4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23537200a18d4363813fcb1d9bc99ad4"}}, "title": "A patient satisfaction survey and educational package to improve the care of people hospitalised with COVID-19: an observational study, Liverpool, UK", "authors": [{"family": "Ahmed", "given": "Muhammad Shamsher", "initials": "MS"}, {"family": "Hicks", "given": "Scott Rory", "initials": "SR"}, {"family": "Watson", "given": "Rebecca", "initials": "R"}, {"family": "Ahmed", "given": "Rajia Akter", "initials": "RA"}, {"family": "Jones", "given": "Lewis", "initials": "L"}, {"family": "Vaselli", "given": "Marcella", "initials": "M"}, {"family": "Wu", "given": "Meng San", "initials": "MS"}, {"family": "Hayat", "given": "Fatima", "initials": "F"}, {"family": "Ratcliffe", "given": "Libuse", "initials": "L"}, {"family": "McKenna", "given": "Mark", "initials": "M"}, {"family": "Hine", "given": "Paul", "initials": "P"}, {"family": "Defres", "given": "Sylviane", "initials": "S"}, {"family": "Wingfield", "given": "Tom", "initials": "T"}], "type": "posted-content", "published": "2021-03-30", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.23.21253630", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-03-31T08:19:04.466Z", "modified": "2021-04-07T10:24:37.804Z"}, {"entity": "publication", "iuid": "9ccdc15ea88a46639b096f5aaabaf24f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ccdc15ea88a46639b096f5aaabaf24f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ccdc15ea88a46639b096f5aaabaf24f"}}, "title": "Sexual health (excluding reproductive health, intimate partner violence and gender-based violence) and COVID-19: a scoping review.", "authors": [{"family": "Kumar", "given": "Navin", "initials": "N"}, {"family": "Janmohamed", "given": "Kamila", "initials": "K"}, {"family": "Nyhan", "given": "Kate", "initials": "K"}, {"family": "Forastiere", "given": "Laura", "initials": "L"}, {"family": "Zhang", "given": "Wei-Hong", "initials": "WH"}, {"family": "K\u00e5gesten", "given": "Anna", "initials": "A"}, {"family": "Uhlich", "given": "Maximiliane", "initials": "M"}, {"family": "Sarpong Frimpong", "given": "Afia", "initials": "A"}, {"family": "Van de Velde", "given": "Sarah", "initials": "S"}, {"family": "Francis", "given": "Joel M", "initials": "JM"}, {"family": "Erausquin", "given": "Jennifer Toller", "initials": "JT"}, {"family": "Larrson", "given": "Elin", "initials": "E"}, {"family": "Callander", "given": "Deton", "initials": "D"}, {"family": "Scott", "given": "John", "initials": "J"}, {"family": "Minichiello", "given": "Victor", "initials": "V"}, {"family": "Tucker", "given": "Joseph", "initials": "J"}], "type": "journal article", "published": "2021-03-29", "journal": {"title": "Sex Transm Infect", "issn": "1472-3263", "volume": null, "issue": null, "issn-l": "1368-4973"}, "abstract": "The COVID-19 pandemic has exposed and exacerbated existing socioeconomic and health disparities, including disparities in sexual health and well-being. While there have been several reviews published on COVID-19 and population health disparities generally-including some with attention to HIV-none has focused on sexual health (ie, STI care, female sexual health, sexual behaviour). We have conducted a scoping review focused on sexual health (excluding reproductive health (RH), intimate partner violence (IPV) and gender-based violence (GBV)) in the COVID-19 era, examining sexual behaviours and sexual health outcomes.\n\nA scoping review, compiling both peer-reviewed and grey literature, focused on sexual health (excluding RH, IPV and GBV) and COVID-19 was conducted on 15 September 2020. Multiple bibliographical databases were searched. Study selection conformed to Joanna Briggs Institute (JBI) Reviewers' Manual 2015 Methodology for JBI Scoping Reviews. We only included English-language original studies.\n\nWe found that men who have sex with men may be moving back toward pre-pandemic levels of sexual activity, and that STI and HIV testing rates seem to have decreased. There was minimal focus on outcomes such as the economic impact on sexual health (excluding RH, IPV and GBV) and STI care, especially STI care of marginalised populations. In terms of population groups, there was limited focus on sex workers or on women, especially women's sexual behaviour and mental health. We noticed limited use of qualitative techniques. Very few studies were in low/middle-income countries (LMICs).\n\nSexual health research is critical during a global infectious disease pandemic and our review of studies suggested notable research gaps. Researchers can focus efforts on LMICs and under-researched topics within sexual health and explore the use of qualitative techniques and interventions where appropriate.", "doi": "10.1136/sextrans-2020-054896", "pmid": "33782145", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "sextrans-2020-054896"}], "notes": [], "created": "2021-03-31T08:14:48.949Z", "modified": "2021-04-23T16:12:40.581Z"}, {"entity": "publication", "iuid": "bdfac6c6a319440bb5a4d00d0851a5fe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bdfac6c6a319440bb5a4d00d0851a5fe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bdfac6c6a319440bb5a4d00d0851a5fe"}}, "title": "Key considerations on the potential impacts of the COVID-19 pandemic on antimicrobial resistance research and surveillance.", "authors": [{"family": "Rodr\u00edguez-Ba\u00f1o", "given": "Jes\u00fas", "initials": "J"}, {"family": "Rossolini", "given": "Gian Maria", "initials": "GM"}, {"family": "Schultsz", "given": "Constance", "initials": "C"}, {"family": "Tacconelli", "given": "Evelina", "initials": "E"}, {"family": "Murthy", "given": "Srinivas", "initials": "S"}, {"family": "Ohmagari", "given": "Norio", "initials": "N"}, {"family": "Holmes", "given": "Alison", "initials": "A"}, {"family": "Bachmann", "given": "Till", "initials": "T"}, {"family": "Goossens", "given": "Herman", "initials": "H"}, {"family": "Canton", "given": "Rafael", "initials": "R"}, {"family": "Roberts", "given": "Adam P", "initials": "AP"}, {"family": "Henriques-Normark", "given": "Birgitta", "initials": "B"}, {"family": "Clancy", "given": "Cornelius J", "initials": "CJ"}, {"family": "Huttner", "given": "Benedikt", "initials": "B"}, {"family": "Fagerstedt", "given": "Patriq", "initials": "P"}, {"family": "Lahiri", "given": "Shawon", "initials": "S"}, {"family": "Kaushic", "given": "Charu", "initials": "C"}, {"family": "Hoffman", "given": "Steven J", "initials": "SJ"}, {"family": "Warren", "given": "Margo", "initials": "M"}, {"family": "Zoubiane", "given": "Ghada", "initials": "G"}, {"family": "Essack", "given": "Sabiha", "initials": "S"}, {"family": "Laxminarayan", "given": "Ramanan", "initials": "R"}, {"family": "Plant", "given": "Laura", "initials": "L"}], "type": "journal article", "published": "2021-03-27", "journal": {"title": "Trans R Soc Trop Med Hyg", "issn": "1878-3503", "volume": null, "issue": null, "issn-l": null}, "abstract": "Antibiotic use in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients during the COVID-19 pandemic has exceeded the incidence of bacterial coinfections and secondary infections, suggesting inappropriate and excessive prescribing. Even in settings with established antimicrobial stewardship (AMS) programmes, there were weaknesses exposed regarding appropriate antibiotic use in the context of the pandemic. Moreover, antimicrobial resistance (AMR) surveillance and AMS have been deprioritised with diversion of health system resources to the pandemic response. This experience highlights deficiencies in AMR containment and mitigation strategies that require urgent attention from clinical and scientific communities. These include the need to implement diagnostic stewardship to assess the global incidence of coinfections and secondary infections in COVID-19 patients, including those by multidrug-resistant pathogens, to identify patients most likely to benefit from antibiotic treatment and identify when antibiotics can be safely withheld, de-escalated or discontinued. Long-term global surveillance of clinical and societal antibiotic use and resistance trends is required to prepare for subsequent changes in AMR epidemiology, while ensuring uninterrupted supply chains and preventing drug shortages and stock outs. These interventions present implementation challenges in resource-constrained settings, making a case for implementation research on AMR. Knowledge and support for these practices will come from internationally coordinated, targeted research on AMR, supporting the preparation for future challenges from emerging AMR in the context of the current COVID-19 pandemic or future pandemics.", "doi": "10.1093/trstmh/trab048", "pmid": "33772597", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "6195536"}], "notes": [], "created": "2021-03-29T09:28:58.612Z", "modified": "2021-03-29T09:28:58.622Z"}, {"entity": "publication", "iuid": "b41b8b76a4534c3e81ce1b931d5bd041", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b41b8b76a4534c3e81ce1b931d5bd041.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b41b8b76a4534c3e81ce1b931d5bd041"}}, "title": "What must be done to tackle vaccine hesitancy and barriers to COVID-19 vaccination in migrants?", "authors": [{"family": "Crawshaw", "given": "Alison F", "initials": "AF"}, {"family": "Deal", "given": "Anna", "initials": "A"}, {"family": "Rustage", "given": "Kieran", "initials": "K"}, {"family": "Forster", "given": "Alice S", "initials": "AS"}, {"family": "Campos-Matos", "given": "Ines", "initials": "I"}, {"family": "Vandrevala", "given": "Tushna", "initials": "T"}, {"family": "W\u00fcrz", "given": "Andrea", "initials": "A"}, {"family": "Pharris", "given": "Anastasia", "initials": "A"}, {"family": "Suk", "given": "Jonathan", "initials": "J"}, {"family": "Kinsman", "given": "John", "initials": "J"}, {"family": "Deogan", "given": "Charlotte", "initials": "C"}, {"family": "Miller", "given": "Anna", "initials": "A"}, {"family": "Declich", "given": "Silvia", "initials": "S"}, {"family": "Greenaway", "given": "Chris", "initials": "C"}, {"family": "Noori", "given": "Teymur", "initials": "T"}, {"family": "Hargreaves", "given": "Sally", "initials": "S"}], "type": "journal article", "published": "2021-03-26", "journal": {"title": "J Travel Med", "issn": "1708-8305", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1093/jtm/taab048", "pmid": "33772312", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6189154"}], "notes": [], "created": "2021-03-29T09:27:31.563Z", "modified": "2021-06-18T15:45:53.420Z"}, {"entity": "publication", "iuid": "6fa79dbdcf4a48edaf5018baab0e0286", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6fa79dbdcf4a48edaf5018baab0e0286.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6fa79dbdcf4a48edaf5018baab0e0286"}}, "title": "The COVID-19 Epidemic: Management and Outcomes of Hemodialysis and Peritoneal Dialysis Patients in Stockholm, Sweden.", "authors": [{"family": "Smolander", "given": "Jessica", "initials": "J"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}], "type": "news", "published": "2021-03-26", "journal": {"title": "Kidney Blood Press Res", "issn": "1423-0143", "volume": "46", "issue": "2", "pages": "1-7", "issn-l": null}, "abstract": "The COVID-19 outbreak has been associated with a high morbidity, mortality, and a risk of long-term sequelae, and patients with severe COVID-19 are at increased risk of acute kidney injury. CKD patients are at high risk of being exposed to COVID-19 and suffer complications and poor outcome. In Sweden, mitigation strategies did not include lockdown. During March-April of 2020, wide-spread infection occurred in Stockholm.\n\nManagement and outcomes in forty hemodialysis (HD) patients and 4 peritoneal dialysis (PD) patients, with symptomatic COVID-19 in greater Stockholm during March and April of 2020 are reported.\n\nTwenty-four HD patients (60%) required medical care and hospitalization, whereas 16 patients (40%) were treated at home. Nine patients died (mortality rate of 22.5%), of whom 8 were men. The median age in non-survivors (78 years) was significantly higher than in survivors (p = 0.003). The median time in dialysis (11.5 years) was also significantly longer in non-survivors (p = 0.01). C-reactive protein (CRP) at diagnosis in 7 of non-survivors (median 213 mg/L, range 86-329 mg/L) was significantly higher than the CRP in 25 survivors (median 87 mg/L, range 1-328 mg/L) (p = 0.0003). Maximum CRP also indicated poorer outcome among hospitalized patients (p = 0.0004). The gender imbalance was striking with only men dying apart from 1 elderly woman. Only 4 PD patients were hospitalized with symptomatic COVID-19. One patient died, 2 were discharged, and 1 was treated at the intensive care unit and survived.\n\nHD patients >70 years were reported with longer dialysis vintage, higher CRP, and males were at an increased risk of dying from COVID-19, whereas those <70 years seemed to have a milder disease. Mitigation strategies to reduce rates of infection in high-risk populations remain essential. Follow-up focusing on long-term prognosis for extrapulmonary manifestations is likely to be important also in dialysis patients.", "doi": "10.1159/000514268", "pmid": "33774645", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "000514268"}], "notes": [], "created": "2021-03-29T09:30:38.838Z", "modified": "2021-04-28T18:08:47.789Z"}, {"entity": "publication", "iuid": "76bcc47259e5489c80a8c7107c73db6d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76bcc47259e5489c80a8c7107c73db6d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76bcc47259e5489c80a8c7107c73db6d"}}, "title": "Pregnancy and risk of COVID-19", "authors": [{"family": "Magnus", "given": "Maria C", "initials": "MC"}, {"family": "Oakley", "given": "Laura", "initials": "L"}, {"family": "K. Gjessing", "given": "H\u00e5kon", "initials": "H"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}, {"family": "Engjom", "given": "Hilde M", "initials": "HM"}, {"family": "Macsali", "given": "Ferenc", "initials": "F"}, {"family": "Juliusson", "given": "Petur B", "initials": "PB"}, {"family": "Andersen", "given": "Anne Marie Nybo", "initials": "AMN"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}], "type": "posted-content", "published": "2021-03-26", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.22.21254090", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-03-31T08:17:27.439Z", "modified": "2021-06-09T19:20:53.081Z"}, {"entity": "publication", "iuid": "0be63deaa6a04dbd94018b9288d6658a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0be63deaa6a04dbd94018b9288d6658a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0be63deaa6a04dbd94018b9288d6658a"}}, "title": "Molecular detection of SARS-CoV-2 being challenged by virus variation and asymptomatic infection.", "authors": [{"family": "Jiang", "given": "Congshan", "initials": "C"}, {"family": "Li", "given": "Xiaowei", "initials": "X"}, {"family": "Ge", "given": "Changrong", "initials": "C"}, {"family": "Ding", "given": "Yuanyuan", "initials": "Y"}, {"family": "Zhang", "given": "Tao", "initials": "T"}, {"family": "Cao", "given": "Shuai", "initials": "S"}, {"family": "Meng", "given": "Liesu", "initials": "L"}, {"family": "Lu", "given": "Shemin", "initials": "S"}], "type": "journal article", "published": "2021-03-26", "journal": {"title": "J Pharm Anal", "issn": "2214-0883", "volume": null, "issue": null, "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) has been a pandemic for more than a year. With the expanding second wave of pandemic in winter, the continuous evolution of SARS-CoV-2 has brought new issues, including the significance of virus mutations in infection and the detection of asymptomatic infection. In this review, we firstly introduced several major SARS-CoV-2 mutations since the COVID-19 outbreak and then mentioned the widely used molecular detection techniques to diagnose COVID-19, primarily focusing on their strengths and limitations. We further discussed the effects of viral genetic variation and asymptomatic infection on the molecular detection of SARS-CoV-2 infection. The review finally summarized useful insights into the molecular diagnosis of COVID-19 under the special situation challenging by virus mutation and asymptomatic infection.", "doi": "10.1016/j.jpha.2021.03.006", "pmid": "33815862", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2095-1779(21)00026-5"}, {"db": "pmc", "key": "PMC7997641"}], "notes": [], "created": "2021-04-06T10:04:49.143Z", "modified": "2021-04-06T10:04:49.166Z"}, {"entity": "publication", "iuid": "ff8aebe28e134ff58876ef8b0f4c1f82", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff8aebe28e134ff58876ef8b0f4c1f82.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff8aebe28e134ff58876ef8b0f4c1f82"}}, "title": "Impact of the COVID-19 Pandemic on Antimicrobial Resistance (AMR) Surveillance, Prevention and Control: A Global Survey", "authors": [{"family": "Tomczyk", "given": "Sara", "initials": "S"}, {"family": "Taylor", "given": "Angelina", "initials": "A"}, {"family": "Brown", "given": "Allison", "initials": "A"}, {"family": "Kraker", "given": "Marlieke de", "initials": "Md"}, {"family": "Eckmanns", "given": "Tim", "initials": "T"}, {"family": "El-Saed", "given": "Aiman", "initials": "A"}, {"family": "Alshamrani", "given": "Majid", "initials": "M"}, {"family": "Hendriksen", "given": "Rene", "initials": "R"}, {"family": "Jacob", "given": "Megan", "initials": "M"}, {"family": "L\u00f6fmark", "given": "Sonja", "initials": "S"}, {"family": "Perovic", "given": "Olga", "initials": "O"}, {"family": "Shetty", "given": "Nandini", "initials": "N"}, {"family": "Sievert", "given": "Dawn", "initials": "D"}, {"family": "Smith", "given": "Rachel", "initials": "R"}, {"family": "Stelling", "given": "John", "initials": "J"}, {"family": "Thakur", "given": "Siddhartha", "initials": "S"}, {"family": "Tornimbene", "given": "Barbara", "initials": "B"}, {"family": "Vietor", "given": "Ann Christin", "initials": "AC"}, {"family": "Eremin", "given": "Sergey", "initials": "S"}], "type": "posted-content", "published": "2021-03-26", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.24.21253807", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-03-31T08:21:46.157Z", "modified": "2021-04-07T10:24:52.698Z"}, {"entity": "publication", "iuid": "5cb6103efe2c4cde859dd9170a6cc94d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5cb6103efe2c4cde859dd9170a6cc94d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5cb6103efe2c4cde859dd9170a6cc94d"}}, "title": "Ultra-fast proteomics with Scanning SWATH.", "authors": [{"family": "Messner", "given": "Christoph B", "initials": "CB"}, {"family": "Demichev", "given": "Vadim", "initials": "V"}, {"family": "Bloomfield", "given": "Nic", "initials": "N"}, {"family": "Yu", "given": "Jason S L", "initials": "JSL"}, {"family": "White", "given": "Matthew", "initials": "M"}, {"family": "Kreidl", "given": "Marco", "initials": "M"}, {"family": "Egger", "given": "Anna-Sophia", "initials": "AS"}, {"family": "Freiwald", "given": "Anja", "initials": "A"}, {"family": "Ivosev", "given": "Gordana", "initials": "G"}, {"family": "Wasim", "given": "Fras", "initials": "F"}, {"family": "Zelezniak", "given": "Aleksej", "initials": "A"}, {"family": "J\u00fcrgens", "given": "Linda", "initials": "L"}, {"family": "Suttorp", "given": "Norbert", "initials": "N"}, {"family": "Sander", "given": "Leif Erik", "initials": "LE"}, {"family": "Kurth", "given": "Florian", "initials": "F"}, {"family": "Lilley", "given": "Kathryn S", "initials": "KS"}, {"family": "M\u00fclleder", "given": "Michael", "initials": "M"}, {"family": "Tate", "given": "Stephen", "initials": "S"}, {"family": "Ralser", "given": "Markus", "initials": "M"}], "type": "journal article", "published": "2021-03-25", "journal": {"title": "Nat Biotechnol", "issn": "1546-1696", "volume": null, "issue": null, "issn-l": null}, "abstract": "Accurate quantification of the proteome remains challenging for large sample series and longitudinal experiments. We report a data-independent acquisition method, Scanning SWATH, that accelerates mass spectrometric (MS) duty cycles, yielding quantitative proteomes in combination with short gradients and high-flow (800 \u00b5l min -1) chromatography. Exploiting a continuous movement of the precursor isolation window to assign precursor masses to tandem mass spectrometry (MS/MS) fragment traces, Scanning SWATH increases precursor identifications by ~70% compared to conventional data-independent acquisition (DIA) methods on 0.5-5-min chromatographic gradients. We demonstrate the application of ultra-fast proteomics in drug mode-of-action screening and plasma proteomics. Scanning SWATH proteomes capture the mode of action of fungistatic azoles and statins. Moreover, we confirm 43 and identify 11 new plasma proteome biomarkers of COVID-19 severity, advancing patient classification and biomarker discovery. Thus, our results demonstrate a substantial acceleration and increased depth in fast proteomic experiments that facilitate proteomic drug screens and clinical studies.", "doi": "10.1038/s41587-021-00860-4", "pmid": "33767396", "labels": {"Category: Proteins": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41587-021-00860-4"}, {"db": "URL", "key": "https://github.com/vdemichev/diann", "description": "Open-source algorithms made available through the DIA\u2013NN software suite"}, {"db": "URL", "key": "http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD023613", "description": "ProteomeXchange PXD023613: data generated for the benchmarks and the drug response screen in yeast"}], "notes": [], "created": "2021-03-29T09:19:46.825Z", "modified": "2021-04-23T16:13:04.586Z"}, {"entity": "publication", "iuid": "bf78c207136341c2905e9e118563642a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf78c207136341c2905e9e118563642a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf78c207136341c2905e9e118563642a"}}, "title": "Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts.", "authors": [{"family": "Molteni", "given": "Erika", "initials": "E", "orcid": "0000-0001-7773-8140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9aed1fbe444b48d4bfacb12050953c8e.json"}}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Magee", "given": "Laura A", "initials": "LA"}, {"family": "Murray", "given": "Benjamin", "initials": "B"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Gomez", "given": "Maria F", "initials": "MF"}, {"family": "Tsereteli", "given": "Neli", "initials": "N"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Brownstein", "given": "John S", "initials": "JS"}, {"family": "Davies", "given": "Richard", "initials": "R"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Spector", "given": "Tim D", "initials": "TD"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "Modat", "given": "Marc", "initials": "M"}], "type": "journal article", "published": "2021-03-25", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "6928"}, "abstract": "We tested whether pregnant and non-pregnant women differ in COVID-19 symptom profile and severity, and we extended previous investigations on hospitalized pregnant women to those who did not require hospitalization. Two female community-based cohorts (18-44 years) provided longitudinal (smartphone application, N = 1,170,315, n = 79 pregnant tested positive) and cross-sectional (web-based survey, N = 1,344,966, n = 134 pregnant tested positive) data, prospectively collected through self-participatory citizen surveillance in UK, Sweden and USA. Pregnant and non-pregnant were compared for frequencies of events, including SARS-CoV-2 testing, symptoms and hospitalization rates. Multivariable regression was used to investigate symptoms severity and comorbidity effects. Pregnant and non-pregnant women positive for SARS-CoV-2 infection were not different in syndromic severity, except for gastrointestinal symptoms. Pregnant were more likely to have received testing, despite reporting fewer symptoms. Pre-existing lung disease was most closely associated with syndromic severity in pregnant hospitalized. Heart and kidney diseases and diabetes increased risk. The most frequent symptoms among non-hospitalized women were anosmia [63% pregnant, 92% non-pregnant] and headache [72%, 62%]. Cardiopulmonary symptoms, including persistent cough [80%] and chest pain [73%], were more frequent among pregnant who were hospitalized. Consistent with observations in non-pregnant populations, lung disease and diabetes were associated with increased risk of more severe SARS-CoV-2 infection during pregnancy.", "doi": "10.1038/s41598-021-86452-3", "pmid": "33767292", "labels": {"Funder: Hj\u00e4rt-Lungfonden": null, "Category: Public Health": null, "Type: Journal article": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC7994587"}, {"db": "pii", "key": "10.1038/s41598-021-86452-3"}], "notes": [], "created": "2021-03-29T09:18:57.274Z", "modified": "2023-06-19T15:07:30.522Z"}, {"entity": "publication", "iuid": "0d40115030b14f5a86f99e3945d1643a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d40115030b14f5a86f99e3945d1643a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d40115030b14f5a86f99e3945d1643a"}}, "title": "Site-Specific O-Glycosylation Analysis of SARS-CoV-2 Spike Protein Produced in Insect and Human Cells.", "authors": [{"family": "Bagdonaite", "given": "Ieva", "initials": "I"}, {"family": "Thompson", "given": "Andrew J", "initials": "AJ"}, {"family": "Wang", "given": "Xiaoning", "initials": "X"}, {"family": "S\u00f8gaard", "given": "Max", "initials": "M"}, {"family": "Fougeroux", "given": "Cyrielle", "initials": "C"}, {"family": "Frank", "given": "Martin", "initials": "M"}, {"family": "Diedrich", "given": "Jolene K", "initials": "JK"}, {"family": "Yates", "given": "John R", "initials": "JR"}, {"family": "Salanti", "given": "Ali", "initials": "A"}, {"family": "Vakhrushev", "given": "Sergey Y", "initials": "SY"}, {"family": "Paulson", "given": "James C", "initials": "JC"}, {"family": "Wandall", "given": "Hans H", "initials": "HH"}], "type": "journal article", "published": "2021-03-25", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "4", "issn-l": "1999-4915"}, "abstract": "Enveloped viruses hijack not only the host translation processes, but also its glycosylation machinery, and to a variable extent cover viral surface proteins with tolerogenic host-like structures. SARS-CoV-2 surface protein S presents as a trimer on the viral surface and is covered by a dense shield of N-linked glycans, and a few O-glycosites have been reported. The location of O-glycans is controlled by a large family of initiating enzymes with variable expression in cells and tissues and hence is difficult to predict. Here, we used our well-established O-glycoproteomic workflows to map the precise positions of O-linked glycosylation sites on three different entities of protein S-insect cell or human cell-produced ectodomains, or insect cell derived receptor binding domain (RBD). In total 25 O-glycosites were identified, with similar patterns in the two ectodomains of different cell origin, and a distinct pattern of the monomeric RBD. Strikingly, 16 out of 25 O-glycosites were located within three amino acids from known N-glycosites. However, O-glycosylation was primarily found on peptides that were unoccupied by N-glycans, and otherwise had low overall occupancy. This suggests possible complementary functions of O-glycans in immune shielding and negligible effects of O-glycosylation on subunit vaccine design for SARS-CoV-2.", "doi": "10.3390/v13040551", "pmid": "33806155", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "v13040551"}], "notes": [], "created": "2021-04-06T10:35:44.200Z", "modified": "2021-04-06T10:35:44.209Z"}, {"entity": "publication", "iuid": "c6c8a24310104994be31f728755aa631", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c6c8a24310104994be31f728755aa631.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c6c8a24310104994be31f728755aa631"}}, "title": "COVID-19 Editorial: Mechanistic Links and Daunting Therapeutic Challenges for Metabolic Diseases One Year after The Beginning of The COVID-19 Pandemic.", "authors": [{"family": "Tessier", "given": "Christopher M", "initials": "CM"}, {"family": "Kokkinos", "given": "Alexander", "initials": "A"}, {"family": "Mingrone", "given": "Geltrude", "initials": "G"}, {"family": "Koliaki", "given": "Chrysi", "initials": "C"}, {"family": "Zierath", "given": "Juleen R", "initials": "JR"}, {"family": "Mantzoros", "given": "Christos S", "initials": "CS"}], "type": "editorial", "published": "2021-03-25", "journal": {"title": "Metabolism", "issn": "1532-8600", "volume": null, "issue": null, "pages": "154769", "issn-l": null}, "abstract": null, "doi": "10.1016/j.metabol.2021.154769", "pmid": "33775648", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0026-0495(21)00069-X"}], "notes": [], "created": "2021-03-30T12:15:01.308Z", "modified": "2021-03-30T12:15:01.324Z"}, {"entity": "publication", "iuid": "e1da34c615124871ae7119f2d1c31ada", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e1da34c615124871ae7119f2d1c31ada.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e1da34c615124871ae7119f2d1c31ada"}}, "title": "A Simple Model for the Total Number of SARS-CoV-2 Infections on a National Level", "authors": [{"family": "Blanco", "given": "N", "initials": "N"}, {"family": "Stafford", "given": "K", "initials": "K"}, {"family": "Lavoie", "given": "M C", "initials": "MC"}, {"family": "Brandenburg", "given": "A", "initials": "A"}, {"family": "G\u00f3rna", "given": "M W", "initials": "MW"}, {"family": "Merski", "given": "M", "initials": "M"}], "type": "journal-article", "published": "2021-03-25", "journal": {"title": "Epidemiol. Infect.", "issn": "0950-2688", "issn-l": null, "volume": null, "issue": null, "pages": "1-25"}, "abstract": null, "doi": "10.1017/s0950268821000649", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.5281/zenodo.4454173", "description": "Raw, original data and fits data set"}], "notes": [], "created": "2021-03-25T14:01:34.383Z", "modified": "2021-06-18T15:40:26.357Z"}, {"entity": "publication", "iuid": "609fc217e83b4e8891e131b5bf0bd9bc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/609fc217e83b4e8891e131b5bf0bd9bc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/609fc217e83b4e8891e131b5bf0bd9bc"}}, "title": "Impact of the COVID-19 pandemic on emergency and elective hip surgeries in Norway.", "authors": [{"family": "Magnusson", "given": "Karin", "initials": "K"}, {"family": "Helgeland", "given": "Jon", "initials": "J"}, {"family": "Gr\u00f8sland", "given": "Mari", "initials": "M"}, {"family": "Telle", "given": "Kjetil", "initials": "K"}], "type": "journal article", "published": "2021-03-24", "journal": {"title": "Acta Orthop", "issn": "1745-3682", "issn-l": null, "volume": null, "issue": null, "pages": "1-5"}, "abstract": "Background and purpose - Many countries implemented strict lockdown policies to control the COVID-19 pandemic during March 2020. The impacts of lockdown policies on joint surgeries are unknown. Therefore, we assessed the effects of COVID-19 pandemic lockdown restrictions on the number of emergency and elective hip joint surgeries, and explored whether these procedures are more/less affected by lockdown restrictions than other hospital care.Patients and methods - In 1,344,355 persons aged \u2265 35 years in the Norwegian emergency preparedness (BEREDT C19) register, we studied the daily number of persons having (1) emergency surgeries due to hip fractures, and (2) electively planned surgeries due to hip osteoarthritis before and after COVID-19 lockdown restrictions were implemented nationally on March 13, 2020, for different age and sex groups. Incidence rate ratios (IRR) reflect the after-lockdown number of surgeries divided by the before-lockdown number of surgeries.Results - After-lockdown elective hip surgeries comprised one-third the number of before-lockdown (IRR \u223c0.3), which is a greater drop than that seen in all-cause elective hospital care (IRR \u223c0.6). Men aged 35-69 had half the number of emergency hip fracture surgeries (IRR \u223c0.6), whereas women aged \u2265 70 had the same number of emergency hip fracture surgeries after lockdown (IRR \u223c1). Only women aged 35-69 and men aged \u2265 70 had emergency hip fracture surgery rates after lockdown comparable to what may be expected based on analyses of all-cause acute care (IRR \u223c0.80)Interpretation - It is important to note for future pandemics management that lockdown restrictions may impact more on scheduled joint surgery than other scheduled hospital care. Lockdown may also impact the number of emergency joint surgeries for men aged \u2265 35 but not those for women aged \u2265 70.", "doi": "10.1080/17453674.2021.1898782", "pmid": "33757405", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-03-25T13:56:55.551Z", "modified": "2021-03-25T13:57:54.036Z"}, {"entity": "publication", "iuid": "dc56fd4c0afb439f9a943617cb5b418a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dc56fd4c0afb439f9a943617cb5b418a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dc56fd4c0afb439f9a943617cb5b418a"}}, "title": "Factors Associated with Emerging and Re-emerging of SARS-CoV-2 Variants", "authors": [{"family": "Spratt", "given": "Austin N", "initials": "AN"}, {"family": "Kannan", "given": "Saathvik R", "initials": "SR"}, {"family": "Woods", "given": "Lucas T", "initials": "LT"}, {"family": "Weisman", "given": "Gary A", "initials": "GA"}, {"family": "Quinn", "given": "Thomas P", "initials": "TP"}, {"family": "Lorson", "given": "Christian L", "initials": "CL"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}, {"family": "Singh", "given": "Kamal", "initials": "K"}], "type": "posted-content", "published": "2021-03-24", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.24.436850", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null}, "xrefs": [], "notes": [], "created": "2021-04-15T18:53:24.322Z", "modified": "2021-04-21T08:36:57.929Z"}, {"entity": "publication", "iuid": "ce949ddad1b34d3cba35a5f617b4f1bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ce949ddad1b34d3cba35a5f617b4f1bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ce949ddad1b34d3cba35a5f617b4f1bf"}}, "title": "Diverse SARS-CoV-2 variants preceded the initial COVID-19 outbreak in Croatia.", "authors": [{"family": "Roki\u0107", "given": "Filip", "initials": "F"}, {"family": "Trgovec-Greif", "given": "Lovro", "initials": "L"}, {"family": "Su\u010di\u0107", "given": "Neven", "initials": "N"}, {"family": "\u010cemelji\u0107", "given": "Noa", "initials": "N"}, {"family": "Grbe\u0161a", "given": "\u0110ur\u0111ica Cekinovi\u0107", "initials": "\u0110C"}, {"family": "Svedru\u017ei\u0107", "given": "\u017deljko", "initials": "\u017d"}, {"family": "Rukavina", "given": "Tomislav", "initials": "T"}, {"family": "Vugrek", "given": "Oliver", "initials": "O"}, {"family": "Jurak", "given": "Igor", "initials": "I"}], "type": "journal article", "published": "2021-03-24", "journal": {"title": "Arch Virol", "issn": "1432-8798", "volume": null, "issue": null, "issn-l": null}, "abstract": "We developed a next-generation SARS-CoV-2 sequencing platform and obtained the first SARS-CoV-2 sequences from patients in Croatia at the beginning of the COVID-19 outbreak in the spring of 2020. Integrating the sequencing and the epidemiological data, we show that patients were infected with different SARS-CoV-2 variants belonging to different clades (mostly G and GH). This result confirms that there was widespread virus transmission early in 2020. Interestingly, we identified a unique mutation resulting in a V13I substitution in Nsp5A, the main viral protease, in a patient who had not received antiviral therapy.", "doi": "10.1007/s00705-021-05029-7", "pmid": "33761008", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00705-021-05029-7"}], "notes": [], "created": "2021-03-25T14:00:14.895Z", "modified": "2021-03-25T14:00:14.918Z"}, {"entity": "publication", "iuid": "1d97075d697d4aafba9f1829a8f000c7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d97075d697d4aafba9f1829a8f000c7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d97075d697d4aafba9f1829a8f000c7"}}, "title": "Challenges and opportunities to end tuberculosis in the COVID-19 era.", "authors": [{"family": "Wingfield", "given": "Tom", "initials": "T"}, {"family": "Karmadwala", "given": "Fatima", "initials": "F"}, {"family": "MacPherson", "given": "Peter", "initials": "P"}, {"family": "Millington", "given": "Kerry A", "initials": "KA"}, {"family": "Walker", "given": "Naomi F", "initials": "NF"}, {"family": "Cuevas", "given": "Luis E", "initials": "LE"}, {"family": "Squire", "given": "S Bertel", "initials": "SB"}], "type": "journal article", "published": "2021-03-24", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "issn-l": "2213-2600", "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/S2213-2600(21)00161-2", "pmid": "33773121", "labels": {"Category: Health": null, "Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(21)00161-2"}], "notes": [], "created": "2021-03-29T09:29:47.710Z", "modified": "2022-02-17T09:34:00.457Z"}, {"entity": "publication", "iuid": "5b6e21b205cd469c8bf809697ef51789", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5b6e21b205cd469c8bf809697ef51789.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5b6e21b205cd469c8bf809697ef51789"}}, "title": "Mental Health, Greenness, and Nature Related Behaviors in the Adult Population of Stockholm County during COVID-19-Related Restrictions.", "authors": [{"family": "L\u00f5hmus", "given": "Mare", "initials": "M"}, {"family": "Stenfors", "given": "Cecilia U D", "initials": "CUD"}, {"family": "Lind", "given": "Tomas", "initials": "T"}, {"family": "Lauber", "given": "Andr\u00e9", "initials": "A"}, {"family": "Georgelis", "given": "Antonios", "initials": "A"}], "type": "journal article", "published": "2021-03-23", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "6", "pages": null}, "abstract": "International data suggest that exposure to nature is beneficial for mental health and well-being. The restrictions related to the COVID-19 pandemic have created a setting that allows us to investigate the importance of greenness exposure on mental health during a period of increased isolation and worry. Based on 2060 responses from an online survey in Stockholm County, Sweden, we investigated: (1) whether the COVID-19 pandemic changed peoples' lifestyle and nature-related habits, and (2) if peoples' mental health differed depending on their exposure to greenness. Neighborhood greenness levels were quantified by using the average normalized difference vegetation index (NDVI) within 50 m, 100 m, 300 m, and 500 m buffers surrounding the participant's place of residence. We found that the number of individuals that reported that they visited natural areas \"often\" was significantly higher during the pandemic than before the pandemic. Higher levels of greenness surrounding one's location of residence were in general associated with higher mental health/well-being and vitality scores, and less symptoms of depression, anxiety, and perceived and cognitive stress, after adjustments for demographic variables and walkability. In conclusion, the results from the present study provided support to the suggestion that contact with nature may be important for mental health in extreme circumstances.", "doi": "10.3390/ijerph18063303", "pmid": "33806787", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "ijerph18063303"}], "notes": [], "created": "2021-04-06T10:33:24.157Z", "modified": "2021-06-18T15:35:59.689Z"}, {"entity": "publication", "iuid": "19d49bc018224174b5c789908cb243f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19d49bc018224174b5c789908cb243f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19d49bc018224174b5c789908cb243f4"}}, "title": "Lifestyle Habits and Mental Health in Light of the Two COVID-19 Pandemic Waves in Sweden, 2020.", "authors": [{"family": "Blom", "given": "Victoria", "initials": "V"}, {"family": "L\u00f6nn", "given": "Amanda", "initials": "A"}, {"family": "Ekblom", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Kallings", "given": "Lena V", "initials": "LV"}, {"family": "V\u00e4is\u00e4nen", "given": "Daniel", "initials": "D"}, {"family": "Hemmingsson", "given": "Erik", "initials": "E"}, {"family": "Andersson", "given": "Gunnar", "initials": "G"}, {"family": "Wallin", "given": "Peter", "initials": "P"}, {"family": "Stenling", "given": "Andreas", "initials": "A"}, {"family": "Ekblom", "given": "\u00d6rjan", "initials": "\u00d6"}, {"family": "Lindwall", "given": "Magnus", "initials": "M"}, {"family": "Salier Eriksson", "given": "Jane", "initials": "J"}, {"family": "Holmlund", "given": "Tobias", "initials": "T"}, {"family": "Ekblom-Bak", "given": "Elin", "initials": "E"}], "type": "journal article", "published": "2021-03-23", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "6", "pages": null}, "abstract": "The COVID-19 pandemic has become a public health emergency of international concern, which may have affected lifestyle habits and mental health. Based on national health profile assessments, this study investigated perceived changes of lifestyle habits in response to the COVID-19 pandemic and associations between perceived lifestyle changes and mental health in Swedish working adults. Among 5599 individuals (50% women, 46.3 years), the majority reported no change (sitting 77%, daily physical activity 71%, exercise 69%, diet 87%, alcohol 90%, and smoking 97%) due to the pandemic. Changes were more pronounced during the first wave (April-June) compared to the second (October-December). Women, individuals <60 years, those with a university degree, white-collar workers, and those with unhealthy lifestyle habits at baseline had higher odds of changing lifestyle habits compared to their counterparts. Negative changes in lifestyle habits and more time in a mentally passive state sitting at home were associated with higher odds of mental ill-health (including health anxiety regarding one's own and relatives' health, generalized anxiety and depression symptoms, and concerns regarding employment and economy). The results emphasize the need to support healthy lifestyle habits to strengthen the resilience in vulnerable groups of individuals to future viral pandemics and prevent health inequalities in society.", "doi": "10.3390/ijerph18063313", "pmid": "33806951", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph18063313"}], "notes": [], "created": "2021-04-06T10:32:29.491Z", "modified": "2021-06-18T15:36:38.808Z"}, {"entity": "publication", "iuid": "47ddf7c0b1374994a86b31d2fb52b9db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47ddf7c0b1374994a86b31d2fb52b9db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47ddf7c0b1374994a86b31d2fb52b9db"}}, "title": "Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation.", "authors": [{"family": "Chioh", "given": "Florence Wj", "initials": "FW"}, {"family": "Fong", "given": "Siew-Wai", "initials": "S"}, {"family": "Young", "given": "Barnaby E", "initials": "BE"}, {"family": "Wu", "given": "Kan-Xing", "initials": "K"}, {"family": "Siau", "given": "Anthony", "initials": "A"}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Chan", "given": "Yi-Hao", "initials": "Y"}, {"family": "Carissimo", "given": "Guillaume", "initials": "G"}, {"family": "Teo", "given": "Louis Ly", "initials": "LL"}, {"family": "Gao", "given": "Fei", "initials": "F"}, {"family": "Tan", "given": "Ru San", "initials": "RS"}, {"family": "Zhong", "given": "Liang", "initials": "L"}, {"family": "Koh", "given": "Angela S", "initials": "AS"}, {"family": "Tan", "given": "Seow-Yen", "initials": "S"}, {"family": "Tambyah", "given": "Paul A", "initials": "PA"}, {"family": "Renia", "given": "Laurent", "initials": "L"}, {"family": "Ng", "given": "Lisa Fp", "initials": "LF"}, {"family": "Lye", "given": "David C", "initials": "DC"}, {"family": "Cheung", "given": "Christine", "initials": "C"}], "type": "journal article", "published": "2021-03-23", "journal": {"title": "Elife", "issn": "2050-084X", "issn-l": null, "volume": "10", "issue": null, "pages": null}, "abstract": "Numerous reports of vascular events after an initial recovery from COVID-19 form our impetus to investigate the impact of COVID-19 on vascular health of recovered patients. We found elevated levels of circulating endothelial cells (CECs), a biomarker of vascular injury, in COVID-19 convalescents compared to healthy controls. In particular, those with pre-existing conditions (e.g., hypertension, diabetes) had more pronounced endothelial activation hallmarks than non-COVID-19 patients with matched cardiovascular risk. Several proinflammatory and activated T lymphocyte-associated cytokines sustained from acute infection to recovery phase, which correlated positively with CEC measures, implicating cytokine-driven endothelial dysfunction. Notably, we found higher frequency of effector T cells in our COVID-19 convalescents compared to healthy controls. The activation markers detected on CECs mapped to counter receptors found primarily on cytotoxic CD8 + T cells, raising the possibility of cytotoxic effector cells targeting activated endothelial cells. Clinical trials in preventive therapy for post-COVID-19 vascular complications may be needed.", "doi": "10.7554/eLife.64909", "pmid": "33752798", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "64909"}], "notes": [], "created": "2021-03-24T06:53:57.063Z", "modified": "2021-07-09T12:41:18.717Z"}, {"entity": "publication", "iuid": "fb10dff4709e4303ba629b04a889cdca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb10dff4709e4303ba629b04a889cdca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb10dff4709e4303ba629b04a889cdca"}}, "title": "Author Correction: COVID-19 vaccine guidance for patients with cancer participating in oncology clinical trials.", "authors": [{"family": "Desai", "given": "Aakash", "initials": "A"}, {"family": "Gainor", "given": "Justin F", "initials": "JF"}, {"family": "Hegde", "given": "Aparna", "initials": "A"}, {"family": "Schram", "given": "Alison M", "initials": "AM"}, {"family": "Curigliano", "given": "Giuseppe", "initials": "G"}, {"family": "Pal", "given": "Sumanta", "initials": "S"}, {"family": "Liu", "given": "Stephen V", "initials": "SV"}, {"family": "Halmos", "given": "Balazs", "initials": "B"}, {"family": "Groisberg", "given": "Roman", "initials": "R"}, {"family": "Grande", "given": "Enrique", "initials": "E"}, {"family": "Dragovich", "given": "Tomislav", "initials": "T"}, {"family": "Matrana", "given": "Marc", "initials": "M"}, {"family": "Agarwal", "given": "Neeraj", "initials": "N"}, {"family": "Chawla", "given": "Sant", "initials": "S"}, {"family": "Kato", "given": "Shumei", "initials": "S"}, {"family": "Morgan", "given": "Gilberto", "initials": "G"}, {"family": "Kasi", "given": "Pashtoon M", "initials": "PM"}, {"family": "Solomon", "given": "Benjamin", "initials": "B"}, {"family": "Loong", "given": "Herbert H", "initials": "HH"}, {"family": "Park", "given": "Haeseong", "initials": "H"}, {"family": "Choueiri", "given": "Toni K", "initials": "TK"}, {"family": "Subbiah", "given": "Ishwaria M", "initials": "IM"}, {"family": "Pemmaraju", "given": "Naveen", "initials": "N"}, {"family": "Subbiah", "given": "Vivek", "initials": "V"}, {"family": "COVID19 and Cancer Clinical Trials Working Group", "given": "", "initials": ""}], "type": "published erratum", "published": "2021-03-23", "journal": {"title": "Nat Rev Clin Oncol", "issn": "1759-4782", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1038/s41571-021-00503-2", "pmid": "33758378", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41571-021-00503-2"}], "notes": [], "created": "2021-03-25T13:59:04.682Z", "modified": "2021-03-25T13:59:21.437Z"}, {"entity": "publication", "iuid": "f701ebff8c074df0a2d724d4d0c577a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f701ebff8c074df0a2d724d4d0c577a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f701ebff8c074df0a2d724d4d0c577a6"}}, "title": "Virus-Induced Changes of the Respiratory Tract Environment Promote Secondary Infections With Streptococcus pneumoniae.", "authors": [{"family": "Sender", "given": "Vicky", "initials": "V"}, {"family": "Hentrich", "given": "Karina", "initials": "K"}, {"family": "Henriques-Normark", "given": "Birgitta", "initials": "B"}], "type": "journal article", "published": "2021-03-22", "journal": {"title": "Front Cell Infect Microbiol", "issn": "2235-2988", "volume": "11", "issue": null, "pages": "643326", "issn-l": null}, "abstract": "Secondary bacterial infections enhance the disease burden of influenza infections substantially. Streptococcus pneumoniae (the pneumococcus) plays a major role in the synergism between bacterial and viral pathogens, which is based on complex interactions between the pathogen and the host immune response. Here, we discuss mechanisms that drive the pathogenesis of a secondary pneumococcal infection after an influenza infection with a focus on how pneumococci senses and adapts to the influenza-modified environment. We briefly summarize what is known regarding secondary bacterial infection in relation to COVID-19 and highlight the need to improve our current strategies to prevent and treat viral bacterial coinfections.", "doi": "10.3389/fcimb.2021.643326", "pmid": "33828999", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8019817"}], "notes": [], "created": "2021-04-09T16:44:47.845Z", "modified": "2021-04-28T18:23:24.262Z"}, {"entity": "publication", "iuid": "8a1b420ce97d49dab7916be3f1fd7515", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a1b420ce97d49dab7916be3f1fd7515.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a1b420ce97d49dab7916be3f1fd7515"}}, "title": "Targeting CX3CR1 Suppresses the Fanconi Anemia DNA Repair Pathway and Synergizes with Platinum.", "authors": [{"family": "Lehto", "given": "Jemina", "initials": "J"}, {"family": "Huguet Ninou", "given": "Anna", "initials": "A"}, {"family": "Chioureas", "given": "Dimitrios", "initials": "D"}, {"family": "Jonkers", "given": "Jos", "initials": "J"}, {"family": "Gustafsson", "given": "Nina M S", "initials": "NMS"}], "type": "journal article", "published": "2021-03-22", "journal": {"title": "Cancers (Basel)", "issn": "2072-6694", "issn-l": null, "volume": "13", "issue": "6", "pages": null}, "abstract": "The C-X3-C motif chemokine receptor 1 (CX3CR1, fractalkine receptor) is associated with neoplastic transformation, inflammation, neurodegenerative diseases and aging, and the small molecule inhibitor KAND567 targeting CX3CR1 (CX3CR1i) is evaluated in clinical trials for acute systemic inflammation upon SARS-CoV-2 infections. Here we identify a hitherto unknown role of CX3CR1 in Fanconi anemia (FA) pathway mediated repair of DNA interstrand crosslinks (ICLs) in replicating cells. FA pathway activation triggers CX3CR1 nuclear localization which facilitates assembly of the key FA protein FANCD2 into foci. Interfering with CX3CR1 function upon ICL-induction results in inability of replicating cells to progress from S phase, replication fork stalling and impaired chromatin recruitment of key FA pathway factors. Consistent with defective FA repair, CX3CR1i results in increased levels of residual cisplatin-DNA adducts and decreased cell survival. Importantly, CX3CR1i synergizes with platinum agents in a nonreversible manner in proliferation assays including platinum resistant models. Taken together, our results reveal an unanticipated interplay between CX3CR1 and the FA pathway and show for the first time that a clinical-phase small molecule inhibitor targeting CX3CR1 might show benefit in improving responses to DNA crosslinking chemotherapeutics.", "doi": "10.3390/cancers13061442", "pmid": "33810010", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "cancers13061442"}], "notes": [], "created": "2021-04-06T10:23:48.973Z", "modified": "2021-04-07T13:23:58.431Z"}, {"entity": "publication", "iuid": "4118c1f7f7d24411a4a599164ed5f37e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4118c1f7f7d24411a4a599164ed5f37e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4118c1f7f7d24411a4a599164ed5f37e"}}, "title": "Risk of severe allergic reactions to COVID-19 vaccines among patients with allergic skin diseases - practical recommendations. A position statement of ETFAD with external experts.", "authors": [{"family": "Ring", "given": "J", "initials": "J"}, {"family": "Worm", "given": "M", "initials": "M"}, {"family": "Wollenberg", "given": "A", "initials": "A"}, {"family": "Thyssen", "given": "J P", "initials": "JP"}, {"family": "Jakob", "given": "T", "initials": "T"}, {"family": "Klimek", "given": "L", "initials": "L"}, {"family": "Bangert", "given": "C", "initials": "C"}, {"family": "Barbarot", "given": "S", "initials": "S"}, {"family": "Bieber", "given": "T", "initials": "T"}, {"family": "de Bruin-Weller", "given": "M S", "initials": "MS"}, {"family": "Chernyshov", "given": "P V", "initials": "PV"}, {"family": "Christen-Zaech", "given": "S", "initials": "S"}, {"family": "Cork", "given": "M", "initials": "M"}, {"family": "Darsow", "given": "U", "initials": "U"}, {"family": "Flohr", "given": "C", "initials": "C"}, {"family": "F\u00f6lster-Holst", "given": "R", "initials": "R"}, {"family": "Gelmetti", "given": "C", "initials": "C"}, {"family": "Gieler", "given": "U", "initials": "U"}, {"family": "Gutermuth", "given": "J", "initials": "J"}, {"family": "Heratizadeh", "given": "A", "initials": "A"}, {"family": "Hijnen", "given": "D J", "initials": "DJ"}, {"family": "von Kobyletzki", "given": "L B", "initials": "LB"}, {"family": "Kunz", "given": "B", "initials": "B"}, {"family": "Paul", "given": "C", "initials": "C"}, {"family": "Seneschal", "given": "Julien", "initials": "J"}, {"family": "Simon", "given": "D", "initials": "D"}, {"family": "Spuls", "given": "P I", "initials": "PI"}, {"family": "Stalder", "given": "J F", "initials": "JF"}, {"family": "Svensson", "given": "A", "initials": "A"}, {"family": "Szalai", "given": "Z", "initials": "Z"}, {"family": "Taieb", "given": "A", "initials": "A"}, {"family": "Torrelo", "given": "A", "initials": "A"}, {"family": "Trzeciak", "given": "M", "initials": "M"}, {"family": "Werfel", "given": "T", "initials": "T"}, {"family": "Weidinger", "given": "S", "initials": "S"}, {"family": "Deleuran", "given": "M", "initials": "M"}], "type": "letter", "published": "2021-03-22", "journal": {"title": "J Eur Acad Dermatol Venereol", "issn": "1468-3083", "volume": null, "issue": null, "issn-l": null}, "abstract": "Since the introduction of active vaccination against SARS-CoV-2 infection, there has been a debate about the risk of developing severe allergic or anaphylactic reactions among individuals with a history of allergy. Indeed, rare cases of severe allergic reactions have been reported in the United Kingdom and North America. By february 2021 a rate of 4,5 severe allergic reactions occurred among 1 million patients vaccinated with the mRNA-based COVID-19 vaccines, which is higher than the generally expected rate of severe allergic reactions to vaccinations of around 1 in 1 million.", "doi": "10.1111/jdv.17237", "pmid": "33752263", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-03-24T06:53:28.426Z", "modified": "2021-03-24T06:53:28.438Z"}, {"entity": "publication", "iuid": "46adafc19dc74c4d9319e7815d83a39b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46adafc19dc74c4d9319e7815d83a39b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46adafc19dc74c4d9319e7815d83a39b"}}, "title": "Measurement Invariance of the Drivers of COVID-19 Vaccination Acceptance Scale: Comparison between Taiwanese and Mainland Chinese-Speaking Populations.", "authors": [{"family": "Yeh", "given": "Ya-Chin", "initials": "Y"}, {"family": "Chen", "given": "I-Hua", "initials": "I"}, {"family": "Ahorsu", "given": "Daniel K", "initials": "DK"}, {"family": "Ko", "given": "Nai-Ying", "initials": "N"}, {"family": "Chen", "given": "Kuan-Lin", "initials": "K"}, {"family": "Li", "given": "Ping-Chia", "initials": "P"}, {"family": "Yen", "given": "Cheng-Fang", "initials": "C"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-03-22", "journal": {"title": "Vaccines", "issn": "2076-393X", "issn-l": null, "volume": "9", "issue": "3", "pages": null}, "abstract": "The impacts of novel coronavirus disease-2019 (COVID-19) on human life continue to be serious. To control the spread of COVID-19, the production of effective vaccines is likely to be one of the best solutions. However, vaccination hesitancy may decrease individuals' willingness to get vaccinated. The Drivers of COVID-19 Vaccination Acceptance Scale (DrVac-COVID19S) was recently developed to help healthcare professionals and researchers better understand vaccination acceptance. The present study examined whether DrVac-COVID19S is measurement invariant across different subgroups (Taiwanese vs. mainland Chinese university students; males vs. females; and health-related program majors vs. non-health-related program majors). Taiwanese ( n = 761; mean age = 25.51 years; standard deviation (SD) = 6.42; 63.5% females) and mainland Chinese university students (n = 3145; mean age = 20.72 years; SD = 2.06; 50.2% females) were recruited using an online survey between 5 January and 21 February 2021. Factor structure and measurement invariance of the two DrVac-COVID19S scales (nine-item and 12-item) were tested using confirmatory factor analysis (CFA). The findings indicated that the DrVac-COVID19S had a four-factor structure and was measurement invariant across the subgroups. The DrVac-COVID19S's four-factor structure was supported by the CFA results is a practical and valid instrument to quickly capture university students' willingness to get COVID-19 vaccination. Moreover, the DrVac-COVID19S can be used to compare university students' underlying reasons to get COVID-19 vaccination among different subgroups.", "doi": "10.3390/vaccines9030297", "pmid": "33810036", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "vaccines9030297"}], "notes": [], "created": "2021-04-06T10:23:00.038Z", "modified": "2021-06-18T15:34:51.780Z"}, {"entity": "publication", "iuid": "8e9da1eddbce4edda487f0a7a41c34f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e9da1eddbce4edda487f0a7a41c34f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e9da1eddbce4edda487f0a7a41c34f7"}}, "title": "Antibody kinetics and clinical course of COVID-19 a prospective observational study.", "authors": [{"family": "Bl\u00e4ckberg", "given": "Anna", "initials": "A"}, {"family": "Fernstr\u00f6m", "given": "Nils", "initials": "N"}, {"family": "Sarbrant", "given": "Emma", "initials": "E"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}, {"family": "Sunnerhagen", "given": "Torgny", "initials": "T"}], "type": "journal article", "published": "2021-03-22", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "3", "pages": "e0248918", "issn-l": "1932-6203"}, "abstract": "Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19.\n\nA prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over time in patients with COVID-19. Possible associations between antibody titers and outcome were analyzed.\n\nForty patients with COVID-19, hospitalized at Sk\u00e5ne University hospital, Sweden, between April and June 2020 were included. IgG antibody responses were detected for all patients with the highest levels four weeks after COVID-19 diagnosis. Levels of IgA were generally higher at diagnosis and decreased towards baseline 4 weeks after confirmed COVID-19. Patients with severe COVID-19 had higher levels of antibodies directed against SARS-CoV-2 spike protein compared with patients with mild disease.\n\nIgG and IgA antibodies towards the spike protein follow different kinetics during COVID-19 and patients with severe disease develop higher antibody levels.", "doi": "10.1371/journal.pone.0248918", "pmid": "33750984", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-01958"}], "notes": [], "created": "2021-03-24T06:57:06.356Z", "modified": "2021-03-24T06:57:06.366Z"}, {"entity": "publication", "iuid": "901e54458cd04c57bd0479eaba9f68ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/901e54458cd04c57bd0479eaba9f68ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/901e54458cd04c57bd0479eaba9f68ca"}}, "title": "Acute kidney injury and mortality risk in older adults with COVID-19.", "authors": [{"family": "Xu", "given": "Hong", "initials": "H"}, {"family": "Garcia-Ptacek", "given": "Sara", "initials": "S"}, {"family": "Annetorp", "given": "Martin", "initials": "M"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Cederholm", "given": "Tommy", "initials": "T"}, {"family": "Johnson", "given": "Peter", "initials": "P"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Metzner", "given": "Carina", "initials": "C"}, {"family": "Religa", "given": "Dorota", "initials": "D"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-03-22", "journal": {"title": "J Nephrol", "issn": "1724-6059", "volume": null, "issue": null, "issn-l": null}, "abstract": "Research regarding COVID-19 and acute kidney injury (AKI) in older adults is scarce. We evaluated risk factors and outcomes of AKI in hospitalized older adults with and without COVID-19.\n\nObservational study of patients admitted to two geriatric clinics in Stockholm from March 1st to June 15th, 2020. The difference in incidence, risk factors and adverse outcomes for AKI between patients with or without COVID-19 were examined. Odds ratios (OR) for the risk of AKI and in-hospital death were obtained from logistic regression.\n\nThree hundred-sixteen older patients were hospitalized for COVID-19 and 876 patients for non-COVID-19 diagnoses. AKI occurred in 92 (29%) patients with COVID-19 vs. 159 (18%) without COVID-19. The odds for developing AKI were higher in patients with COVID-19 (adjusted OR, 1.70; 95% confidence interval [CI] 1.04-2.76), low baseline kidney function as depicted by estimated glomerular filtration rate (eGFR) [4.19 (2.48-7.05), for eGFR 30 to < 60 mL/min, and 20.3 (9.95-41.3) for eGFR < 30 mL/min], and higher C reactive protein (CRP) (OR 1.81 (1.11-2.95) in patients with initial CRP > 10 mg/L). Compared to patients without COVID-19 and without AKI, the risk of in-hospital death was highest in patients with COVID-19 and AKI [OR 80.3, 95% CI (27.3-235.6)], followed by COVID-19 without AKI [16.3 (6.28-42.4)], and by patients without COVID-19 and with AKI [10.2 (3.66-28.2)].\n\nGeriatric patients hospitalized with COVID-19 had a higher incidence of AKI compared to patients hospitalized for other diagnoses. COVID-19 and reduced baseline kidney function were risk factors for developing AKI. AKI and COVID-19 were associated with in-hospital death.", "doi": "10.1007/s40620-021-01022-0", "pmid": "33751497", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40620-021-01022-0"}], "notes": [], "created": "2021-03-24T06:55:25.358Z", "modified": "2021-03-24T06:56:15.523Z"}, {"entity": "publication", "iuid": "c737c114c2434b338293ab491edc103d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c737c114c2434b338293ab491edc103d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c737c114c2434b338293ab491edc103d"}}, "title": "Identification of Potential SARS-CoV-2 Main Protease and Spike Protein Inhibitors from the Genus Aloe: An In Silico Study for Drug Development.", "authors": [{"family": "Abouelela", "given": "Mohamed E", "initials": "ME"}, {"family": "Assaf", "given": "Hamdy K", "initials": "HK"}, {"family": "Abdelhamid", "given": "Reda A", "initials": "RA"}, {"family": "Elkhyat", "given": "Ehab S", "initials": "ES"}, {"family": "Sayed", "given": "Ahmed M", "initials": "AM"}, {"family": "Oszako", "given": "Tomasz", "initials": "T"}, {"family": "Belbahri", "given": "Lassaad", "initials": "L"}, {"family": "El Zowalaty", "given": "Ahmed E", "initials": "AE"}, {"family": "Abdelkader", "given": "Mohamed Salaheldin A", "initials": "MSA"}], "type": "journal article", "published": "2021-03-21", "journal": {"title": "Molecules", "issn": "1420-3049", "volume": "26", "issue": "6", "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus (SARS-CoV-2) disease is a global rapidly spreading virus showing very high rates of complications and mortality. Till now, there is no effective specific treatment for the disease. Aloe is a rich source of isolated phytoconstituents that have an enormous range of biological activities. Since there are no available experimental techniques to examine these compounds for antiviral activity against SARS-CoV-2, we employed an in silico approach involving molecular docking, dynamics simulation, and binding free energy calculation using SARS-CoV-2 essential proteins as main protease and spike protein to identify lead compounds from Aloe that may help in novel drug discovery. Results retrieved from docking and molecular dynamics simulation suggested a number of promising inhibitors from Aloe. Root mean square deviation (RMSD) and root mean square fluctuation (RMSF) calculations indicated that compounds 132, 134, and 159 were the best scoring compounds against main protease, while compounds 115, 120, and 131 were the best scoring ones against spike glycoprotein. Compounds 120 and 131 were able to achieve significant stability and binding free energies during molecular dynamics simulation. In addition, the highest scoring compounds were investigated for their pharmacokinetic properties and drug-likeness. The Aloe compounds are promising active phytoconstituents for drug development for SARS-CoV-2.", "doi": "10.3390/molecules26061767", "pmid": "33801151", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "molecules26061767"}], "notes": [], "created": "2021-04-06T10:39:45.088Z", "modified": "2021-04-06T10:39:45.099Z"}, {"entity": "publication", "iuid": "c23fb84e01e842a283193fca3cd80504", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c23fb84e01e842a283193fca3cd80504.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c23fb84e01e842a283193fca3cd80504"}}, "title": "Fear of COVID-19 Scale (FCV-19S) across countries: Measurement invariance issues.", "authors": [{"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Hou", "given": "Wen-Li", "initials": "W"}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA"}, {"family": "Aparecido da Silva", "given": "Jos\u00e9", "initials": "J"}, {"family": "Broche-P\u00e9rez", "given": "Yunier", "initials": "Y"}, {"family": "Ullah", "given": "Irfan", "initials": "I"}, {"family": "Masuyama", "given": "Akihiro", "initials": "A"}, {"family": "Wakashima", "given": "Koubun", "initials": "K"}, {"family": "Mailliez", "given": "M\u00e9lody", "initials": "M"}, {"family": "Carre", "given": "Arnaud", "initials": "A"}, {"family": "Chen", "given": "Yu-Pin", "initials": "Y"}, {"family": "Chang", "given": "Kun-Chia", "initials": "K"}, {"family": "Kuo", "given": "Yi-Jie", "initials": "Y"}, {"family": "Soraci", "given": "Paolo", "initials": "P"}, {"family": "Scarf", "given": "Damian", "initials": "D"}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-03-21", "journal": {"title": "Nurs Open", "issn": "2054-1058", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The threats of novel coronavirus disease 2019 (COVID-19) have caused fears worldwide. The Fear of COVID-19 Scale (FCV-19S) was recently developed to assess the fear of COVID-19. Although many studies found that the FCV-19S is psychometrically sound, it is unclear whether the FCV-19S is invariant across countries. The present study aimed to examine the measurement invariance of the FCV-19S across eleven countries.\r\n\r\nCross-sectional study.\r\n\r\nUsing data collected from prior research on Bangladesh (N = 8,550), United Kingdom (N = 344), Brazil (N = 1,843), Taiwan (N = 539), Italy (N = 249), New Zealand (N = 317), Iran (N = 717), Cuba (N = 772), Pakistan (N = 937), Japan (N = 1,079) and France (N = 316), comprising a total 15,663 participants, the present study used the multigroup confirmatory factor analysis (CFA) and Rasch differential item functioning (DIF) to examine the measurement invariance of the FCV-19S across country, gender and age (children aged below 18 years, young to middle-aged adults aged between 18 and 60 years, and older people aged above 60 years).\r\n\r\nThe unidimensional structure of the FCV-19S was confirmed. Multigroup CFA showed that FCV-19S was partially invariant across country and fully invariant across gender and age. DIF findings were consistent with the findings from multigroup CFA. Many DIF items were displayed for country, few DIF items were displayed for age, and no DIF items were displayed for gender.\r\n\r\nBased on the results of the present study, the FCV-19S is a good psychometric instrument to assess fear of COVID-19 during the pandemic period. Moreover, the use of FCV-19S is supported in at least ten countries with satisfactory psychometric properties.", "doi": "10.1002/nop2.855", "pmid": "33745219", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-24T07:00:44.363Z", "modified": "2021-06-18T15:29:27.945Z"}, {"entity": "publication", "iuid": "a2a1735641c64bba9ec00b061e463c38", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2a1735641c64bba9ec00b061e463c38.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2a1735641c64bba9ec00b061e463c38"}}, "title": "Anti-SARS-CoV2 antibody responses in serum and cerebrospinal fluid of COVID-19 patients with neurological symptoms", "authors": [{"family": "Cunningham", "given": "Janet L", "initials": "JL"}, {"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B"}, {"family": "Castro Dopico", "given": "Xaquin", "initials": "X"}, {"family": "Kolstad", "given": "Linda", "initials": "L"}, {"family": "Albinsson", "given": "Bo", "initials": "B"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "N\u00e4\u00e4s", "given": "Anja", "initials": "A"}, {"family": "Klang", "given": "Andrea", "initials": "A"}, {"family": "Westman", "given": "Gabriel", "initials": "G"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e314740b02c344d2b336a9410e28041e.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Rostami", "given": "Elham", "initials": "E", "orcid": "0000-0003-1218-6247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c95efe7a4cc4fcfa73fac8b49641ca1.json"}}], "type": "journal-article", "published": "2021-03-21", "journal": {"title": "The Journal of Infectious Diseases", "issn": "0022-1899", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Antibody responses to SARS-CoV-2 in serum and CSF from 16 COVID-19 patients with neurological symptoms were assessed using two independent methods. IgG specific for the virus spike protein was found in 81% of cases in serum and in 56% in CSF. SARS-CoV-2 IgG in CSF was observed in two cases with negative serology. Levels of IgG in both serum and CSF were associated with disease severity (p<0.05). All patients with elevated markers of CNS damage in CSF also had CSF antibodies (p=0.002), and CSF antibodies had the highest predictive value for neuronal damage markers of all tested clinical variables.", "doi": "10.1093/infdis/jiab153", "pmid": "33744954", "labels": {"Category: Health": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Funder: VR": null, "Category: Proteins": null, "Funder: H2020": null, "Research Area: High-throughput and high-content serology": null}, "xrefs": [{"db": "pii", "key": "6179304"}, {"db": "pmc", "key": "PMC8083780"}], "notes": [], "created": "2021-03-22T10:01:02.020Z", "modified": "2021-12-12T18:07:55.909Z"}, {"entity": "publication", "iuid": "038bbdb7ac4b4dd283edbe6d0049a203", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/038bbdb7ac4b4dd283edbe6d0049a203.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/038bbdb7ac4b4dd283edbe6d0049a203"}}, "title": "An Agent-Based Model of Local Pandemic Spread: Analysis of SARS-CoV-2.", "authors": [{"family": "Staffini", "given": "Alessio", "initials": "A"}, {"family": "Svensson", "given": "Akiko Kishi", "initials": "AK"}, {"family": "Chung", "given": "Ung-Il", "initials": "UI"}, {"family": "Svensson", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2021-03-21", "journal": {"title": "JMIR Med Inform", "issn": "2291-9694", "volume": null, "issue": null, "issn-l": null}, "abstract": "The spread of the SARS-CoV-2 virus originating in Wuhan, China, was classified as a pandemic by the World Health Organization (WHO) on March 11, 2020. The governments of affected countries have implemented various measures to limit the spread of the virus. The starting point of this paper is the different government approaches, in terms of promulgating new legislative regulations to limit the virus diffusion and to contain negative effects on the populations.\n\nThe objective of this paper is to study how the spread of the SARS-CoV-2 virus is linked to the government policies, and to analyse how different policies have produced different results on public health.\n\nConsidering the official data provided by 4 countries (Italy, Germany, Sweden and Brazil) and from the measures implemented by their respective governments, we built an Agent-Based Model (ABM) to study the effects that these measures will have over time on different variables such as the total number of COVID-19 cases, intensive care unit (ICU) bed occupancy rates, and recovery and case fatality rates. The model we implemented provides for the possibility of modifying some starting variables, and it was thus possible to study the effects that some policies (such as keeping the national borders closed or the increase in ICU beds) would have had on the spread of the infection.\n\nThe 4 considered countries have adopted different containment measures for SARS-CoV-2, and the forecasts provided by the model for the considered variables have given different results. Italy and Germany seem to be able to limit the spread of the infection and any eventual \"second wave\", while Sweden and Brazil do not seem to have the situation under control. This situation is reflected also in the forecasts of pressure on the National Health Services, which see Sweden and Brazil with a high occupancy rate of ICU beds also in the coming months, with a consequent high number of deaths.\n\nIn line with what we expected, the obtained results show that the countries that have taken very restrictive measures in terms of limiting the mobility of the population have managed, more successfully than others, to contain the spread of SARS-CoV-2. Moreover, the model demonstrates that herd immunity cannot be reached even in countries which have relied on a strategy without strict containment measures.\n\nNot Applicable.", "doi": "10.2196/24192", "pmid": "33750735", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-03-24T06:57:45.986Z", "modified": "2021-03-24T06:57:57.046Z"}, {"entity": "publication", "iuid": "2ccb5a5c59b647dbb970f0e5430d547c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ccb5a5c59b647dbb970f0e5430d547c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ccb5a5c59b647dbb970f0e5430d547c"}}, "title": "A bispecific monomeric nanobody induces SARS-COV-2 spike trimer dimers", "authors": [{"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Das", "given": "Hrishikesh", "initials": "H"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Vidakovics", "given": "Laura Perez", "initials": "LP"}, {"family": "Urgard", "given": "Egon", "initials": "E"}, {"family": "Moliner-Morro", "given": "Ainhoa", "initials": "A"}, {"family": "Karl", "given": "Vivien", "initials": "V"}, {"family": "Pankow", "given": "Alec", "initials": "A"}, {"family": "Kim", "given": "Changil", "initials": "C"}, {"family": "Smith", "given": "Natalie L", "initials": "NL"}, {"family": "Pedersen", "given": "Gabriel K", "initials": "GK"}, {"family": "Coquet", "given": "Jonathan M", "initials": "JM"}, {"family": "H\u00e4llberg", "given": "B Martin", "initials": "BM"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}], "type": "posted-content", "published": "2021-03-21", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.20.436243", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "Materials will be made available when the article is published in a journal", "description": null}], "notes": [], "created": "2021-03-24T06:32:39.788Z", "modified": "2021-04-15T18:54:39.609Z"}, {"entity": "publication", "iuid": "2e9b4e77e3da40ebbfa0ec005dcac230", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e9b4e77e3da40ebbfa0ec005dcac230.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e9b4e77e3da40ebbfa0ec005dcac230"}}, "title": "COVID-19 collateral damage: psychological distress and behavioral changes among older adults during the first outbreak in Stockholm, Sweden", "authors": [{"family": "Beridze", "given": "Giorgi", "initials": "G"}, {"family": "Triolo", "given": "Federico", "initials": "F"}, {"family": "Grande", "given": "Giulia", "initials": "G"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A"}], "type": "posted-content", "published": "2021-03-20", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.16.21253750", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null, "Funder: VR": null}, "xrefs": [{"db": "URL", "key": "http://www.snac-k.se/", "description": "Data available through the the Swedish National study on Aging and Care in Kungsholmen"}], "notes": [], "created": "2021-03-25T14:03:00.839Z", "modified": "2021-04-26T18:07:59.411Z"}, {"entity": "publication", "iuid": "cc0d3b576b9545758a36e109cd7cb47d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc0d3b576b9545758a36e109cd7cb47d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc0d3b576b9545758a36e109cd7cb47d"}}, "title": "Alternative splicing of OAS1 alters the risk for severe COVID-19", "authors": [{"family": "Huffman", "given": "Jennifer", "initials": "J"}, {"family": "Butler-Laporte", "given": "Guillaume", "initials": "G"}, {"family": "Khan", "given": "Atlas", "initials": "A"}, {"family": "Drivas", "given": "Theodore G", "initials": "TG"}, {"family": "Peloso", "given": "Gina M", "initials": "GM"}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T"}, {"family": "Verma", "given": "Anurag", "initials": "A"}, {"family": "Kiryluk", "given": "Krzysztof", "initials": "K"}, {"family": "Richards", "given": "J Brent", "initials": "JB"}, {"family": "Zeberg", "given": "Hugo", "initials": "H"}], "type": "posted-content", "published": "2021-03-20", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.20.21254005", "pmid": null, "labels": {"Category: Genomics & transcriptomics": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-03-25T14:09:33.955Z", "modified": "2021-03-29T10:15:48.708Z"}, {"entity": "publication", "iuid": "e053d3a1434949cba8dbc6919d1f7f5a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e053d3a1434949cba8dbc6919d1f7f5a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e053d3a1434949cba8dbc6919d1f7f5a"}}, "title": "Umbilical cord blood-derived microglia-like cells to model COVID-19 exposure.", "authors": [{"family": "Sheridan", "given": "Steven D", "initials": "SD"}, {"family": "Thanos", "given": "Jessica M", "initials": "JM", "orcid": "0000-0001-7984-5361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc172e4bc4f14c81b166a2d59a696dc8.json"}}, {"family": "De Guzman", "given": "Rose M", "initials": "RM", "orcid": "0000-0002-4563-8628", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/288794dac78b4cb4b0d22b66d11d96d0.json"}}, {"family": "McCrea", "given": "Liam T", "initials": "LT", "orcid": "0000-0002-6738-4681", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3433cc21b02f4c3da64a9b0d78b7af64.json"}}, {"family": "Horng", "given": "Joy E", "initials": "JE"}, {"family": "Fu", "given": "Ting", "initials": "T"}, {"family": "Sellgren", "given": "Carl M", "initials": "CM"}, {"family": "Perlis", "given": "Roy H", "initials": "RH", "orcid": "0000-0002-5862-6757", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1335ae4cb1c48b3987d8e3188ca7a33.json"}}, {"family": "Edlow", "given": "Andrea G", "initials": "AG"}], "type": "journal article", "published": "2021-03-19", "journal": {"title": "Transl Psychiatry", "issn": "2158-3188", "volume": "11", "issue": "1", "pages": "179", "issn-l": null}, "abstract": "Microglia, the resident brain immune cells, play a critical role in normal brain development, and are impacted by the intrauterine environment, including maternal immune activation and inflammatory exposures. The COVID-19 pandemic presents a potential developmental immune challenge to the fetal brain, in the setting of maternal SARS-CoV-2 infection with its attendant potential for cytokine production and, in severe cases, cytokine storming. There is currently no biomarker or model for in utero microglial priming and function that might aid in identifying the neonates and children most vulnerable to neurodevelopmental morbidity, as microglia remain inaccessible in fetal life and after birth. This study aimed to generate patient-derived microglial-like cell models unique to each neonate from reprogrammed umbilical cord blood mononuclear cells, adapting and extending a novel methodology previously validated for adult peripheral blood mononuclear cells. We demonstrate that umbilical cord blood mononuclear cells can be used to create microglial-like cell models morphologically and functionally similar to microglia observed in vivo. We illustrate the application of this approach by generating microglia from cells exposed and unexposed to maternal SARS-CoV-2 infection. Our ability to create personalized neonatal models of fetal brain immune programming enables non-invasive insights into fetal brain development and potential childhood neurodevelopmental vulnerabilities for a range of maternal exposures, including COVID-19.", "doi": "10.1038/s41398-021-01287-w", "pmid": "33741894", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41398-021-01287-w"}, {"db": "pmc", "key": "PMC7976669"}], "notes": [], "created": "2021-03-22T10:28:54.662Z", "modified": "2021-11-18T13:50:03.787Z"}, {"entity": "publication", "iuid": "443177b2f06947178dc99c1684f325fb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/443177b2f06947178dc99c1684f325fb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/443177b2f06947178dc99c1684f325fb"}}, "title": "Exploring associations between children's obesogenic behaviours and local environment using big data.", "authors": [{"family": "Filos", "given": "Dimitris", "initials": "D"}, {"family": "Lekka", "given": "Irini", "initials": "I"}, {"family": "Kilintzis", "given": "Vasileios", "initials": "V"}, {"family": "Stefanopoulos", "given": "Leandros", "initials": "L"}, {"family": "Karavidopoulou", "given": "Youla", "initials": "Y"}, {"family": "Maramis", "given": "Christos", "initials": "C"}, {"family": "Diou", "given": "Christos", "initials": "C"}, {"family": "Sarafis", "given": "Ioannis", "initials": "I"}, {"family": "Papapanagiotou", "given": "Vasileios", "initials": "V"}, {"family": "Alagialoglou", "given": "Leonidas", "initials": "L"}, {"family": "Ioakeimidis", "given": "Ioannis", "initials": "I"}, {"family": "Hassapidou", "given": "Maria", "initials": "M"}, {"family": "Charmandari", "given": "Evangelia", "initials": "E"}, {"family": "Heimeier", "given": "Rachel", "initials": "R"}, {"family": "O'Donnell", "given": "Shane", "initials": "S"}, {"family": "Doyle", "given": "Gerardine", "initials": "G"}, {"family": "Delopoulos", "given": "Anastasios", "initials": "A"}, {"family": "Maglaveras", "given": "Nicos", "initials": "N"}], "type": "journal article", "published": "2021-03-19", "journal": {"title": "JMIR Mhealth Uhealth", "issn": "2291-5222", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Obesity is a major public health problem globally and in Europe, while the prevalence of childhood obesity is also soaring. Several parameters of the living environment are contributing to this increase, such as the density of fast-food retailers, and thus, preventive health policies against childhood obesity must focus on the environment to which children are exposed. Currently, there are no systems to objectively measure the effect of living environment parameters on obesogenic behaviours and obesity. The H2020 project \"BigO: Big Data Against Childhood Obesity\" (http://bigoprogram.eu) aims to tackle childhood obesity by creating new sources of evidence based on big data.\r\n\r\nThis paper introduces the Obesity Prevention dashboard (OPdashboard), implemented in the context of BigO, which offers an interactive data exploration of objective obesity related behaviours and local environment based on the data recorded using the BigO mHealth app.\r\n\r\nOPdashboard allows for (i) the real time monitoring of children's obesogenic behaviours in a city area, (ii) the extraction of associations between them and the local environment and, (iii) the evaluation of an intervention in time. More than 3700 children, from 33 schools and 2 clinics, in 5 European cities have been monitored using a custom-made mobile application for the extraction of behavioural patterns through the capturing of accelerometer and geolocation data, while online databases were assessed in order to have a description of the environment.\r\n\r\nThe preliminary association outcomes in two European cities, namely Thessaloniki in Greece and Stockholm in Sweden, indicate a correlation between children's eating and physical activity behaviours and the availability of food related places or sport facilities close to schools. In addition, OPdashboard was used to assess the modification of children's physical activity as the result of the health policies applied for the deceleration of the COVID-19 outbreak. The preliminary outcomes of the analysis revealed that in urban areas the decrease on physical activity was statistically significant, while in the suburbs a slight increase was observed. Those findings suggest the importance of the availability of open spaces on children's behavioural change. The above analyses act as initial investigations using the OPdashboard. Additional factors must be incorporated in order to optimize its use and have a clearer understanding of the results.\r\n\r\nThe paper describes in detail the OPdashboard which is exposed as a web interface (http://bigo.med.auth.gr:3838/). Its functionality was evaluated during a focus group with experts on public health, where its potential on the better understanding of the interplay between children's obesogenic behaviours and the environment was underlined.", "doi": "10.2196/26290", "pmid": "34048353", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-06-04T11:40:32.420Z", "modified": "2022-11-23T09:01:40.333Z"}, {"entity": "publication", "iuid": "9ddc9e800b23454e99345e581344e71c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ddc9e800b23454e99345e581344e71c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ddc9e800b23454e99345e581344e71c"}}, "title": "A privacy and security analysis of early-deployed COVID-19 contact tracing Android apps.", "authors": [{"family": "Hatamian", "given": "Majid", "initials": "M"}, {"family": "Wairimu", "given": "Samuel", "initials": "S"}, {"family": "Momen", "given": "Nurul", "initials": "N"}, {"family": "Fritsch", "given": "Lothar", "initials": "L"}], "type": "journal article", "published": "2021-03-19", "journal": {"title": "Empir Softw Eng", "issn": "1573-7616", "volume": "26", "issue": "3", "pages": "36", "issn-l": null}, "abstract": "As this article is being drafted, the SARS-CoV-2/COVID-19 pandemic is causing harm and disruption across the world. Many countries aimed at supporting their contact tracers with the use of digital contact tracing apps in order to manage and control the spread of the virus. Their idea is the automatic registration of meetings between smartphone owners for the quicker processing of infection chains. To date, there are many contact tracing apps that have already been launched and used in 2020. There has been a lot of speculations about the privacy and security aspects of these apps and their potential violation of data protection principles. Therefore, the developers of these apps are constantly criticized because of undermining users' privacy, neglecting essential privacy and security requirements, and developing apps under time pressure without considering privacy- and security-by-design. In this study, we analyze the privacy and security performance of 28 contact tracing apps available on Android platform from various perspectives, including their code's privileges, promises made in their privacy policies, and static and dynamic performances. Our methodology is based on the collection of various types of data concerning these 28 apps, namely permission requests, privacy policy texts, run-time resource accesses, and existing security vulnerabilities. Based on the analysis of these data, we quantify and assess the impact of these apps on users' privacy. We aimed at providing a quick and systematic inspection of the earliest contact tracing apps that have been deployed on multiple continents. Our findings have revealed that the developers of these apps need to take more cautionary steps to ensure code quality and to address security and privacy vulnerabilities. They should more consciously follow legal requirements with respect to apps' permission declarations, privacy principles, and privacy policy contents.", "doi": "10.1007/s10664-020-09934-4", "pmid": "33776548", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "9934"}, {"db": "pmc", "key": "PMC7978168"}], "notes": [], "created": "2021-03-30T12:15:34.168Z", "modified": "2021-03-30T12:15:34.179Z"}, {"entity": "publication", "iuid": "a9f78ac5ac6a4f04858a5282781170b8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a9f78ac5ac6a4f04858a5282781170b8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a9f78ac5ac6a4f04858a5282781170b8"}}, "title": "Proteomic blood profiling in mild, severe and critical COVID-19 patients.", "authors": [{"family": "Patel", "given": "Hamel", "initials": "H", "orcid": "0000-0001-7951-6728", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21f5082b1f284a9b901e66759825d8c6.json"}}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0002-3579-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0ae25211e354556a737b1a23c53c6e1.json"}}, {"family": "Dobson", "given": "Richard J B", "initials": "RJB", "orcid": "0000-0003-4224-9245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e3de8d16fca4e7f86f4b1245047e9d0.json"}}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Gisslen", "given": "Magnus", "initials": "M"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e314740b02c344d2b336a9410e28041e.json"}}], "type": "comparative study", "published": "2021-03-18", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "6357"}, "abstract": "The recent SARS-CoV-2 pandemic manifests itself as a mild respiratory tract infection in most individuals, leading to COVID-19 disease. However, in some infected individuals, this can progress to severe pneumonia and acute respiratory distress syndrome (ARDS), leading to multi-organ failure and death. This study explores the proteomic differences between mild, severe, and critical COVID-19 positive patients to further understand the disease progression, identify proteins associated with disease severity, and identify potential therapeutic targets. Blood protein profiling was performed on 59 COVID-19 mild (n = 26), severe (n = 9) or critical (n = 24) cases and 28 controls using the OLINK inflammation, autoimmune, cardiovascular and neurology panels. Differential expression analysis was performed within and between disease groups to generate nine different analyses. From the 368 proteins measured per individual, more than 75% were observed to be significantly perturbed in COVID-19 cases. Six proteins (IL6, CKAP4, Gal-9, IL-1ra, LILRB4 and PD-L1) were identified to be associated with disease severity. The results have been made readily available through an interactive web-based application for instant data exploration and visualization, and can be accessed at https://phidatalab-shiny.rosalind.kcl.ac.uk/COVID19/ . Our results demonstrate that dynamic changes in blood proteins associated with disease severity can potentially be used as early biomarkers to monitor disease severity in COVID-19 and serve as potential therapeutic targets.", "doi": "10.1038/s41598-021-85877-0", "pmid": "33737684", "labels": {"Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Biomarkers and systems immunology": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7973581"}, {"db": "pii", "key": "10.1038/s41598-021-85877-0"}], "notes": [], "created": "2020-11-11T06:47:50.601Z", "modified": "2023-06-19T14:41:38.563Z"}, {"entity": "publication", "iuid": "10d64921899648ee8b9c8e5d2b75d28f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/10d64921899648ee8b9c8e5d2b75d28f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/10d64921899648ee8b9c8e5d2b75d28f"}}, "title": "Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care.", "authors": [{"family": "Pillon", "given": "Nicolas J", "initials": "NJ"}, {"family": "Loos", "given": "Ruth J F", "initials": "RJF"}, {"family": "Marshall", "given": "Sally M", "initials": "SM"}, {"family": "Zierath", "given": "Juleen R", "initials": "JR"}], "type": "journal article", "published": "2021-03-18", "journal": {"title": "Cell", "issn": "1097-4172", "issn-l": "0092-8674", "volume": "184", "issue": "6", "pages": "1530-1544"}, "abstract": "The prevalence of type 2 diabetes and obesity has risen dramatically for decades and is expected to rise further, secondary to the growing aging, sedentary population. The strain on global health care is projected to be colossal. This review explores the latest work and emerging ideas related to genetic and environmental factors influencing metabolism. Translational research and clinical applications, including the impact of the COVID-19 pandemic, are highlighted. Looking forward, strategies to personalize all aspects of prevention, management and care are necessary to improve health outcomes and reduce the impact of these metabolic diseases.", "doi": "10.1016/j.cell.2021.02.012", "pmid": "33675692", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0092-8674(21)00162-8"}], "notes": [], "created": "2021-03-08T10:47:30.864Z", "modified": "2021-11-18T11:57:32.775Z"}, {"entity": "publication", "iuid": "49040feeb8204cadb4e9d7acb2c4f66a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49040feeb8204cadb4e9d7acb2c4f66a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49040feeb8204cadb4e9d7acb2c4f66a"}}, "title": "Working from home during the COVID-19 outbreak in Sweden: effects on 24-h time-use in office workers.", "authors": [{"family": "Hallman", "given": "David M", "initials": "DM"}, {"family": "Januario", "given": "Leticia Bergamin", "initials": "LB"}, {"family": "Mathiassen", "given": "Svend Erik", "initials": "SE"}, {"family": "Heiden", "given": "Marina", "initials": "M"}, {"family": "Svensson", "given": "Sven", "initials": "S"}, {"family": "Bergstr\u00f6m", "given": "Gunnar", "initials": "G"}], "type": "journal article", "published": "2021-03-17", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "528"}, "abstract": "The COVID-19 pandemic has triggered national recommendations encouraging people to work from home (WFH), but the possible impact of WFH on physical behaviors is unknown. This study aimed to determine the extent to which the 24-h allocation of time to different physical behaviors changes between days working at the office (WAO) and days WFH in office workers during the pandemic.\r\n\r\nData were collected on 27 office workers with full-time employment at a Swedish municipal division during the COVID-19 outbreak in May-July 2020. A thigh-worn accelerometer (Axivity) was used to assess physical behavior (sedentary, stand, move) during seven consecutive days. A diary was used to identify periods of work, leisure and sleep. 24-h compositions of sedentary, standing and moving behaviors during work and non-work time were examined using Compositional data analysis (CoDA), and differences between days WAO and days WFH were determined using repeated measures ANOVA.\r\n\r\nDays WFH were associated with more time spent sleeping relative to awake, and the effect size was large (F = 7.4; p = 0.01; \u03b7 p2 = 0.22). The increase (34 min) in sleep time during WFH occurred at the expense of a reduction in work and leisure time by 26 min and 7 min, respectively. Sedentary, standing and moving behaviors did not change markedly during days WFH compared to days WAO.\r\n\r\nDays working from home during the COVID-19 pandemic in Sweden were associated with longer duration of sleep than days working at the office. This behavioral change may be beneficial to health.", "doi": "10.1186/s12889-021-10582-6", "pmid": "33731066", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-10582-6"}, {"db": "pmc", "key": "PMC7968563"}], "notes": [], "created": "2021-03-22T10:50:49.831Z", "modified": "2021-06-18T15:27:29.077Z"}, {"entity": "publication", "iuid": "1716a22867ba40bc9096731dff09d97c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1716a22867ba40bc9096731dff09d97c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1716a22867ba40bc9096731dff09d97c"}}, "title": "Assessment of protection against reinfection with SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020: a population-level observational study.", "authors": [{"family": "Hansen", "given": "Christian Holm", "initials": "CH"}, {"family": "Michlmayr", "given": "Daniela", "initials": "D"}, {"family": "Gubbels", "given": "Sophie Madeleine", "initials": "SM"}, {"family": "M\u00f8lbak", "given": "K\u00e5re", "initials": "K"}, {"family": "Ethelberg", "given": "Steen", "initials": "S"}], "type": "journal article", "published": "2021-03-17", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": null, "issue": null, "issn-l": "0140-6736"}, "abstract": "The degree to which infection with SARS-CoV-2 confers protection towards subsequent reinfection is not well described. In 2020, as part of Denmark's extensive, free-of-charge PCR-testing strategy, approximately 4 million individuals (69% of the population) underwent 10\u00b76 million tests. Using these national PCR-test data from 2020, we estimated protection towards repeat infection with SARS-CoV-2.\n\nIn this population-level observational study, we collected individual-level data on patients who had been tested in Denmark in 2020 from the Danish Microbiology Database and analysed infection rates during the second surge of the COVID-19 epidemic, from Sept 1 to Dec 31, 2020, by comparison of infection rates between individuals with positive and negative PCR tests during the first surge (March to May, 2020). For the main analysis, we excluded people who tested positive for the first time between the two surges and those who died before the second surge. We did an alternative cohort analysis, in which we compared infection rates throughout the year between those with and without a previous confirmed infection at least 3 months earlier, irrespective of date. We also investigated whether differences were found by age group, sex, and time since infection in the alternative cohort analysis. We calculated rate ratios (RRs) adjusted for potential confounders and estimated protection against repeat infection as 1 - RR.\n\nDuring the first surge (ie, before June, 2020), 533 381 people were tested, of whom 11 727 (2\u00b720%) were PCR positive, and 525 339 were eligible for follow-up in the second surge, of whom 11 068 (2\u00b711%) had tested positive during the first surge. Among eligible PCR-positive individuals from the first surge of the epidemic, 72 (0\u00b765% [95% CI 0\u00b751-0\u00b782]) tested positive again during the second surge compared with 16 819 (3\u00b727% [3\u00b722-3\u00b732]) of 514 271 who tested negative during the first surge (adjusted RR 0\u00b7195 [95% CI 0\u00b7155-0\u00b7246]). Protection against repeat infection was 80\u00b75% (95% CI 75\u00b74-84\u00b75). The alternative cohort analysis gave similar estimates (adjusted RR 0\u00b7212 [0\u00b7179-0\u00b7251], estimated protection 78\u00b78% [74\u00b79-82\u00b71]). In the alternative cohort analysis, among those aged 65 years and older, observed protection against repeat infection was 47\u00b71% (95% CI 24\u00b77-62\u00b78). We found no difference in estimated protection against repeat infection by sex (male 78\u00b74% [72\u00b71-83\u00b72] vs female 79\u00b71% [73\u00b79-83\u00b73]) or evidence of waning protection over time (3-6 months of follow-up 79\u00b73% [74\u00b74-83\u00b73] vs \u22657 months of follow-up 77\u00b77% [70\u00b79-82\u00b79]).\n\nOur findings could inform decisions on which groups should be vaccinated and advocate for vaccination of previously infected individuals because natural protection, especially among older people, cannot be relied on.\n\nNone.", "doi": "10.1016/S0140-6736(21)00575-4", "pmid": "33743221", "labels": {"Category: Public Health": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)00575-4"}], "notes": [], "created": "2021-03-22T10:13:10.682Z", "modified": "2021-03-22T10:13:10.692Z"}, {"entity": "publication", "iuid": "7f2312c9703141e0992299306a9f8e5e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f2312c9703141e0992299306a9f8e5e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f2312c9703141e0992299306a9f8e5e"}}, "title": "Virological and immunological features of SARS-CoV-2-infected children who develop neutralizing antibodies.", "authors": [{"family": "Cotugno", "given": "Nicola", "initials": "N"}, {"family": "Ruggiero", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-1041-7489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e47b6216d0514a37818f676dce75ff57.json"}}, {"family": "Bonfante", "given": "Francesco", "initials": "F"}, {"family": "Petrara", "given": "Maria Raffaella", "initials": "MR"}, {"family": "Zicari", "given": "Sonia", "initials": "S", "orcid": "0000-0003-1240-8057", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0379fd354fd3492aa5d5fe8ea9e16065.json"}}, {"family": "Pascucci", "given": "Giuseppe Rubens", "initials": "GR", "orcid": "0000-0002-5978-1193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cfa33536b1242949e2195412e11f541.json"}}, {"family": "Zangari", "given": "Paola", "initials": "P"}, {"family": "De Ioris", "given": "Maria Antonietta", "initials": "MA"}, {"family": "Santilli", "given": "Veronica", "initials": "V"}, {"family": "Manno", "given": "E C", "initials": "EC"}, {"family": "Amodio", "given": "Donato", "initials": "D", "orcid": "0000-0003-4550-3018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8036babccffd453ab3dda55c13a204fa.json"}}, {"family": "Bortolami", "given": "Alessio", "initials": "A"}, {"family": "Pagliari", "given": "Matteo", "initials": "M"}, {"family": "Concato", "given": "Carlo", "initials": "C"}, {"family": "Linardos", "given": "Giulia", "initials": "G"}, {"family": "Campana", "given": "Andrea", "initials": "A"}, {"family": "Don\u00e0", "given": "Daniele", "initials": "D"}, {"family": "Giaquinto", "given": "Carlo", "initials": "C"}, {"family": "CACTUS Study Team", "given": "", "initials": ""}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}, {"family": "Rossi", "given": "Paolo", "initials": "P"}, {"family": "De Rossi", "given": "Anita", "initials": "A", "orcid": "0000-0001-6435-7509", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a4a32409ace4604983c5773c28c7c9e.json"}}, {"family": "Palma", "given": "Paolo", "initials": "P", "orcid": "0000-0002-3066-4719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36e1a02e86a142c2b2d131154fb46f1c.json"}}], "type": "journal article", "published": "2021-03-16", "journal": {"title": "Cell Rep", "issn": "2211-1247", "volume": "34", "issue": "11", "pages": "108852", "issn-l": null}, "abstract": "As the global COVID-19 pandemic progresses, it is paramount to gain knowledge on adaptive immunity to SARS-CoV-2 in children to define immune correlates of protection upon immunization or infection. We analyzed anti-SARS-CoV-2 antibodies and their neutralizing activity (PRNT) in 66 COVID-19-infected children at 7 (\u00b12) days after symptom onset. Individuals with specific humoral responses presented faster virus clearance and lower viral load associated with a reduced in vitro infectivity. We demonstrated that the frequencies of SARS-CoV-2-specific CD4+CD40L+ T cells and Spike-specific B cells were associated with the anti-SARS-CoV-2 antibodies and the magnitude of neutralizing activity. The plasma proteome confirmed the association between cellular and humoral SARS-CoV-2 immunity, and PRNT+ patients show higher viral signal transduction molecules (SLAMF1, CD244, CLEC4G). This work sheds lights on cellular and humoral anti-SARS-CoV-2 responses in children, which may drive future vaccination trial endpoints and quarantine measures policies.", "doi": "10.1016/j.celrep.2021.108852", "pmid": "33730580", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7962998"}, {"db": "pii", "key": "S2211-1247(21)00166-2"}], "notes": [], "created": "2021-03-22T10:53:29.904Z", "modified": "2023-06-19T15:18:16.124Z"}, {"entity": "publication", "iuid": "bcf96a7cfc6548a3b5054f75641dca84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bcf96a7cfc6548a3b5054f75641dca84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bcf96a7cfc6548a3b5054f75641dca84"}}, "title": "Impact of COVID-19 pandemic on utilisation of healthcare services: a systematic review.", "authors": [{"family": "Moynihan", "given": "Ray", "initials": "R"}, {"family": "Sanders", "given": "Sharon", "initials": "S"}, {"family": "Michaleff", "given": "Zoe A", "initials": "ZA"}, {"family": "Scott", "given": "Anna Mae", "initials": "AM"}, {"family": "Clark", "given": "Justin", "initials": "J"}, {"family": "To", "given": "Emma J", "initials": "EJ"}, {"family": "Jones", "given": "Mark", "initials": "M"}, {"family": "Kitchener", "given": "Eliza", "initials": "E"}, {"family": "Fox", "given": "Melissa", "initials": "M"}, {"family": "Johansson", "given": "Minna", "initials": "M"}, {"family": "Lang", "given": "Eddy", "initials": "E"}, {"family": "Duggan", "given": "Anne", "initials": "A"}, {"family": "Scott", "given": "Ian", "initials": "I"}, {"family": "Albarqouni", "given": "Loai", "initials": "L"}], "type": "journal article", "published": "2021-03-16", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "3", "pages": "e045343", "issn-l": "2044-6055"}, "abstract": "To determine the extent and nature of changes in utilisation of healthcare services during COVID-19 pandemic.\n\nSystematic review.\n\nEligible studies compared utilisation of services during COVID-19 pandemic to at least one comparable period in prior years. Services included visits, admissions, diagnostics and therapeutics. Studies were excluded if from single centres or studied only patients with COVID-19.\n\nPubMed, Embase, Cochrane COVID-19 Study Register and preprints were searched, without language restrictions, until 10 August, using detailed searches with key concepts including COVID-19, health services and impact.\n\nRisk of bias was assessed by adapting the Risk of Bias in Non-randomised Studies of Interventions tool, and a Cochrane Effective Practice and Organization of Care tool. Results were analysed using descriptive statistics, graphical figures and narrative synthesis.\n\nPrimary outcome was change in service utilisation between prepandemic and pandemic periods. Secondary outcome was the change in proportions of users of healthcare services with milder or more severe illness (eg, triage scores).\n\n3097 unique references were identified, and 81 studies across 20 countries included, reporting on >11 million services prepandemic and 6.9 million during pandemic. For the primary outcome, there were 143 estimates of changes, with a median 37% reduction in services overall (IQR -51% to -20%), comprising median reductions for visits of 42% (-53% to -32%), admissions 28% (-40% to -17%), diagnostics 31% (-53% to -24%) and for therapeutics 30% (-57% to -19%). Among 35 studies reporting secondary outcomes, there were 60 estimates, with 27 (45%) reporting larger reductions in utilisation among people with a milder spectrum of illness, and 33 (55%) reporting no difference.\n\nHealthcare utilisation decreased by about a third during the pandemic, with considerable variation, and with greater reductions among people with less severe illness. While addressing unmet need remains a priority, studies of health impacts of reductions may help health systems reduce unnecessary care in the postpandemic recovery.\n\nCRD42020203729.", "doi": "10.1136/bmjopen-2020-045343", "pmid": "33727273", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-045343"}, {"db": "pmc", "key": "PMC7969768"}], "notes": [], "created": "2021-03-22T11:33:37.299Z", "modified": "2021-03-22T11:33:47.567Z"}, {"entity": "publication", "iuid": "b55606ceb58b4ef0a6080dc2afa9ee50", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b55606ceb58b4ef0a6080dc2afa9ee50.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b55606ceb58b4ef0a6080dc2afa9ee50"}}, "title": "COVIDENZA - A prospective, multicenter, randomized PHASE II clinical trial of enzalutamide treatment to decrease the morbidity in patients with Corona virus disease 2019 (COVID-19): a structured summary of a study protocol for a randomised controlled trial.", "authors": [{"family": "Wel\u00e9n", "given": "Karin", "initials": "K"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Freyhult", "given": "Eva", "initials": "E"}, {"family": "Robinsson", "given": "David", "initials": "D"}, {"family": "Henningsson", "given": "Anna Jonsson", "initials": "AJ"}, {"family": "Stranne", "given": "Johan", "initials": "J"}, {"family": "Bremell", "given": "Daniel", "initials": "D"}, {"family": "Angelin", "given": "Martin", "initials": "M"}, {"family": "Lindquist", "given": "Elisabeth", "initials": "E"}, {"family": "Buckland", "given": "Robert", "initials": "R"}, {"family": "Carlsson", "given": "Camilla Thellenberg", "initials": "CT"}, {"family": "Pauksens", "given": "Karlis", "initials": "K"}, {"family": "Bill-Axelsson", "given": "Anna", "initials": "A"}, {"family": "Akre", "given": "Olof", "initials": "O"}, {"family": "Ryden", "given": "Cecilia", "initials": "C"}, {"family": "Wagenius", "given": "Magnus", "initials": "M"}, {"family": "Bjartell", "given": "Anders", "initials": "A"}, {"family": "Nilsson", "given": "Anna C", "initials": "AC"}, {"family": "Styrke", "given": "Johan", "initials": "J"}, {"family": "Repo", "given": "Johanna", "initials": "J"}, {"family": "Balkhed", "given": "\u00c5se \u00d6stholm", "initials": "\u00c5\u00d6"}, {"family": "Niward", "given": "Katarina", "initials": "K"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Josefsson", "given": "Andreas", "initials": "A"}], "type": "letter", "published": "2021-03-16", "journal": {"title": "Trials", "issn": "1745-6215", "issn-l": null, "volume": "22", "issue": "1", "pages": "209"}, "abstract": "The main goal of the COVIDENZA trial is to evaluate if inhibition of testosterone signalling by enzalutamide can improve the outcome of patients hospitalised for COVID-19. The hypothesis is based on the observation that the majority of patients in need of intensive care are male, and the connection between androgen receptor signalling and expression of TMPRSS2, an enzyme important for SARS-CoV-2 host cell internalization.\r\n\r\nHospitalised COVID-19 patients will be randomised (2:1) to enzalutamide plus standard of care vs. standard of care designed to identify superiority.\r\n\r\nIncluded participants, men or women above 50 years of age, must be hospitalised for PCR confirmed COVID-19 symptoms and not in need of immediate mechanical ventilation. Major exclusion criteria are breast-feeding or pregnant women, hormonal treatment for prostate or breast cancer, treatment with immunosuppressive drugs, current symptomatic unstable cardiovascular disease (see Additional file 1 for further details). The trial is registered at Ume\u00e5 University Hospital, Region V\u00e4sterbotten, Sweden and 8 hospitals are approved for inclusion in Sweden.\r\n\r\nPatients randomised to the treatment arm will be treated orally with 160 mg (4x40 mg) enzalutamide (Xtandi\u00ae) daily, for five consecutive days. The study is not placebo controlled. The comparator is standard of care treatment for patients hospitalised with COVID-19.\r\n\r\nThe primary endpoints of the study are (time to) need of mechanical ventilation or discharge from hospital as assessed by a clinical 7-point ordinal scale (up to 30 days after inclusion).\r\n\r\nRandomisation was stratified by center and sex. Each strata was randomized separately with block size six with a 2:1 allocation ratio (enzalutamide + \"standard of care\": \"standard of care\"). The randomisation list, with consecutive subject numbers, was generated by an independent statistician using the PROC PLAN procedure of SAS version 9.4 software (SAS Institute, Inc, Cary, North Carolina) BLINDING (MASKING): This is an open-label trial.\r\n\r\nThe trial is designed to have three phases. The first, an exploration phase of 45 participants (30 treatment and 15 control) will focus on safety and includes a more extensive laboratory assessment as well as more frequent safety evaluation. The second prolongation phase, includes the first 100 participants followed by an interim analysis to define the power of the study. The third phase is the continuation of the study up to maximum 600 participants included in total.\r\n\r\nThe current protocol version is COVIDENZA v2.0 as of September 10, 2020. Recruitment started July 29, 2020 and is presently in safety pause after the first exploration phase. Recruitment is anticipated to be complete by 31 December 2021.\r\n\r\nEudract number 2020-002027-10 ClinicalTrials.gov Identifier: NCT04475601 , registered June 8, 2020 FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.", "doi": "10.1186/s13063-021-05137-4", "pmid": "33726804", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13063-021-05137-4"}, {"db": "pmc", "key": "PMC7961321"}, {"db": "ClinicalTrials.gov", "key": "NCT04475601"}], "notes": [], "created": "2021-03-22T11:34:31.938Z", "modified": "2021-04-26T17:39:07.975Z"}, {"entity": "publication", "iuid": "a7368389e0b64b0f98a017d224b876f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7368389e0b64b0f98a017d224b876f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7368389e0b64b0f98a017d224b876f1"}}, "title": "COVID-19 vaccine guidance for patients with cancer participating in oncology clinical trials.", "authors": [{"family": "Desai", "given": "Aakash", "initials": "A"}, {"family": "Gainor", "given": "Justin F", "initials": "JF"}, {"family": "Hegde", "given": "Aparna", "initials": "A"}, {"family": "Schram", "given": "Alison M", "initials": "AM"}, {"family": "Curigiliano", "given": "Guiseppe", "initials": "G"}, {"family": "Pal", "given": "Sumanta", "initials": "S"}, {"family": "Liu", "given": "Stephen V", "initials": "SV"}, {"family": "Halmos", "given": "Balazs", "initials": "B"}, {"family": "Groisberg", "given": "Roman", "initials": "R"}, {"family": "Grande", "given": "Enrique", "initials": "E"}, {"family": "Dragovich", "given": "Tomislav", "initials": "T"}, {"family": "Matrana", "given": "Marc", "initials": "M"}, {"family": "Agarwal", "given": "Neeraj", "initials": "N"}, {"family": "Chawla", "given": "Sant", "initials": "S"}, {"family": "Kato", "given": "Shumei", "initials": "S"}, {"family": "Morgan", "given": "Gilberto", "initials": "G"}, {"family": "Kasi", "given": "Pashtoon M", "initials": "PM"}, {"family": "Solomon", "given": "Benjamin", "initials": "B"}, {"family": "Loong", "given": "Herbert H", "initials": "HH"}, {"family": "Park", "given": "Haeseong", "initials": "H"}, {"family": "Choueiri", "given": "Toni K", "initials": "TK"}, {"family": "Subbiah", "given": "Ishwaria M", "initials": "IM"}, {"family": "Pemmaraju", "given": "Naveen", "initials": "N"}, {"family": "Subbiah", "given": "Vivek", "initials": "V"}, {"family": "COVID19 and Cancer Clinical Trials Working Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-03-15", "journal": {"title": "Nat Rev Clin Oncol", "issn": "1759-4782", "volume": null, "issue": null, "issn-l": null}, "abstract": "Emerging efficacy data have led to the emergency use authorization or approval of COVID-19 vaccines in several countries worldwide. Most trials of COVID-19 vaccines excluded patients with active malignancies, and thus data on the safety, tolerability and efficacy of the vaccines in patients with cancer are currently limited. Given the risk posed by the COVID-19 pandemic, decisions regarding the use of vaccines against COVID-19 in patients participating in trials of investigational anticancer therapies need to be addressed promptly. Patients should not have to choose between enrolling on oncology clinical trials and receiving a COVID-19 vaccine. Clinical trial sponsors, investigators and treating physicians need operational guidance on COVID-19 vaccination for patients with cancer who are currently enrolled or might seek to enrol in clinical trials. Considering the high morbidity and mortality from COVID-19 in patients with cancer, the benefits of vaccination are likely to far outweigh the risks of vaccine-related adverse events. Herein, we provide operational COVID-19 vaccine guidance for patients participating in oncology clinical trials. In our perspective, continued quality oncological care requires that patients with cancer, including those involved in trials, be prioritized for COVID-19 vaccination, which should not affect trial eligibility.", "doi": "10.1038/s41571-021-00487-z", "pmid": "33723371", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41571-021-00487-z"}], "notes": [], "created": "2021-03-17T07:43:19.672Z", "modified": "2021-03-22T11:39:43.055Z"}, {"entity": "publication", "iuid": "900795e8be414da9a5320172e73e4ed4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/900795e8be414da9a5320172e73e4ed4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/900795e8be414da9a5320172e73e4ed4"}}, "title": "Cardiac arrest in COVID-19: characteristics and outcomes of in- and out-of-hospital cardiac arrest. A report from the Swedish Registry for Cardiopulmonary Resuscitation", "authors": [{"family": "Sultanian", "given": "Pedram", "initials": "P"}, {"family": "Lundgren", "given": "Peter", "initials": "P"}, {"family": "Str\u00f6ms\u00f6e", "given": "Anneli", "initials": "A"}, {"family": "Aune", "given": "Solveig", "initials": "S"}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G"}, {"family": "Hagberg", "given": "Eva", "initials": "E"}, {"family": "Hollenberg", "given": "Jacob", "initials": "J"}, {"family": "Lindqvist", "given": "Jonny", "initials": "J"}, {"family": "Dj\u00e4rv", "given": "Therese", "initials": "T"}, {"family": "Castelheim", "given": "Albert", "initials": "A"}, {"family": "Thor\u00e9n", "given": "Anna", "initials": "A"}, {"family": "Hessulf", "given": "Fredrik", "initials": "F"}, {"family": "Svensson", "given": "Leif", "initials": "L"}, {"family": "Claesson", "given": "Andreas", "initials": "A"}, {"family": "Friberg", "given": "Hans", "initials": "H"}, {"family": "Nordberg", "given": "Per", "initials": "P"}, {"family": "Omerovic", "given": "Elmir", "initials": "E"}, {"family": "Rosengren", "given": "Annika", "initials": "A"}, {"family": "Herlitz", "given": "Johan", "initials": "J"}, {"family": "Rawshani", "given": "Araz", "initials": "A"}], "type": "journal-article", "published": "2021-03-14", "journal": {"title": "Eur Heart J", "issn": "0195-668X", "issn-l": null, "volume": "42", "issue": "11", "pages": "1094-1106"}, "abstract": null, "doi": "10.1093/eurheartj/ehaa1067", "pmid": null, "labels": {"Funder: Hj\u00e4rt-Lungfonden": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-25T17:10:04.621Z", "modified": "2021-06-18T15:26:06.336Z"}, {"entity": "publication", "iuid": "50db707ebaa94540b6b438f659d837fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50db707ebaa94540b6b438f659d837fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50db707ebaa94540b6b438f659d837fa"}}, "title": "Persistence of SARS-CoV-2-specific B and T cell responses in convalescent COVID-19 patients 6-8 months after the infection.", "authors": [{"family": "Sherina", "given": "Natalia", "initials": "N"}, {"family": "Piralla", "given": "Antonio", "initials": "A"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Wan", "given": "Hui", "initials": "H"}, {"family": "Kumagai-Braesch", "given": "Makiko", "initials": "M"}, {"family": "Andr\u00e9ll", "given": "Juni", "initials": "J"}, {"family": "Braesch-Andersen", "given": "Sten", "initials": "S"}, {"family": "Cassaniti", "given": "Irene", "initials": "I"}, {"family": "Percivalle", "given": "Elena", "initials": "E"}, {"family": "Sarasini", "given": "Antonella", "initials": "A"}, {"family": "Bergami", "given": "Federica", "initials": "F"}, {"family": "Di Martino", "given": "Raffaella", "initials": "R"}, {"family": "Colaneri", "given": "Marta", "initials": "M"}, {"family": "Vecchia", "given": "Marco", "initials": "M"}, {"family": "Sambo", "given": "Margherita", "initials": "M"}, {"family": "Zuccaro", "given": "Valentina", "initials": "V"}, {"family": "Bruno", "given": "Raffaele", "initials": "R"}, {"family": "Sachs", "given": "Michele", "initials": "M"}, {"family": "Oggionni", "given": "Tiberio", "initials": "T"}, {"family": "Meloni", "given": "Federica", "initials": "F"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Bertoglio", "given": "Federico", "initials": "F"}, {"family": "Schubert", "given": "Maren", "initials": "M"}, {"family": "Byrne-Steele", "given": "Miranda", "initials": "M"}, {"family": "Han", "given": "Jian", "initials": "J"}, {"family": "Hust", "given": "Michael", "initials": "M"}, {"family": "Xue", "given": "Yintong", "initials": "Y"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}], "type": "journal article", "published": "2021-03-12", "journal": {"title": "Med (N Y)", "issn": "2666-6340", "issn-l": null, "volume": "2", "issue": "3", "pages": "281-295.e4"}, "abstract": "Monitoring the adaptive immune responses during the natural course of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection provides useful information for the development of vaccination strategies against this virus and its emerging variants. We thus profiled the serum anti-SARS-CoV-2 antibody (Ab) levels and specific memory B and T cell responses in convalescent coronavirus disease 2019 (COVID-19) patients.\n\nA total of 119 samples from 88 convalescent donors who experienced mild to critical disease were tested for the presence of elevated anti-spike and anti-receptor binding domain Ab levels over a period of 8 months. In addition, the levels of SARS-CoV-2 neutralizing Abs and specific memory B and T cell responses were tested in a subset of samples.\n\nAnti-SARS-CoV-2 Abs were present in 85% of the samples collected within 4 weeks after the onset of symptoms in COVID-19 patients. Levels of specific immunoglobulin M (IgM)/IgA Abs declined after 1 month, while levels of specific IgG Abs and plasma neutralizing activities remained relatively stable up to 6 months after diagnosis. Anti-SARS-CoV-2 IgG Abs were still present, although at a significantly lower level, in 80% of the samples collected at 6-8 months after symptom onset. SARS-CoV-2-specific memory B and T cell responses developed with time and were persistent in all of the patients followed up for 6-8 months.\n\nOur data suggest that protective adaptive immunity following natural infection of SARS-CoV-2 may persist for at least 6-8 months, regardless of disease severity. Development of medium- or long-term protective immunity through vaccination may thus be possible.\n\nThis project was supported by the European Union's Horizon 2020 research and innovation programme (ATAC, no. 101003650), the Italian Ministry of Health (Ricerca Finalizzata grant no. GR-2013-02358399), the Center for Innovative Medicine, and the Swedish Research Council. J.A. was supported by the SciLifeLab/KAW national COVID-19 research program project grant 2020.", "doi": "10.1016/j.medj.2021.02.001", "pmid": "33589885", "labels": {"Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Research Area: High-throughput and high-content serology": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S2666-6340(21)00038-6"}, {"db": "pmc", "key": "PMC7874960"}], "notes": [], "created": "2021-02-17T14:55:48.819Z", "modified": "2021-12-12T18:07:23.858Z"}, {"entity": "publication", "iuid": "79aa0ace4ea74d2080d6c5bdc0c42be7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79aa0ace4ea74d2080d6c5bdc0c42be7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79aa0ace4ea74d2080d6c5bdc0c42be7"}}, "title": "Oxygen provision to severely ill COVID-19 patients at the peak of the 2020 pandemic in a Swedish district hospital", "authors": [{"family": "Hvarfner", "given": "Anna", "initials": "A"}, {"family": "Al-Djaber", "given": "Ahmed", "initials": "A"}, {"family": "Ekstrom", "given": "Hampus", "initials": "H"}, {"family": "Enarsson", "given": "Malin", "initials": "M"}, {"family": "Castegren", "given": "Markus", "initials": "M"}, {"family": "Baker", "given": "Tim", "initials": "T"}, {"family": "Schell", "given": "Carl Otto", "initials": "CO"}], "type": "posted-content", "published": "2021-03-12", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.11.21253350", "pmid": null, "labels": {"Category: Health": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-03-25T14:04:28.506Z", "modified": "2021-03-31T08:20:11.539Z"}, {"entity": "publication", "iuid": "bb5ddc2c0e004a5a8558b2c87b6026d3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb5ddc2c0e004a5a8558b2c87b6026d3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb5ddc2c0e004a5a8558b2c87b6026d3"}}, "title": "Mapping the human genetic architecture of COVID-19 by worldwide meta-analysis", "authors": [{"family": null, "given": "", "initials": ""}, {"family": "Ganna", "given": "Andrea", "initials": "A", "orcid": "0000-0002-8147-240X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b7f6041889a4ebbab284d4ea5647a50.json"}}], "type": "posted-content", "published": "2021-03-12", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.10.21252820", "pmid": null, "labels": {"Category: Genomics & transcriptomics": null, "Type: Preprint": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "URL", "key": "https://www.covid19hg.org/results/r5/", "description": "Summary statistics generated by COVID-19 HGI"}, {"db": "URL", "key": "https://github.com/marcoralab/MRcovid", "description": "Code for Mendelian randomization and genetic correlation pipeline"}, {"db": "URL", "key": "https://github.com/covid19-hg/", "description": "Code for summary statistics liftover and meta-analysis and PCA pipeline"}], "notes": [], "created": "2021-03-15T17:29:56.885Z", "modified": "2022-02-06T17:38:55.641Z"}, {"entity": "publication", "iuid": "051c1aac317d46c08affde26d18af82b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/051c1aac317d46c08affde26d18af82b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/051c1aac317d46c08affde26d18af82b"}}, "title": "Indoor Model Simulation for COVID-19 Transport and Exposure.", "authors": [{"family": "Hussein", "given": "Tareq", "initials": "T"}, {"family": "L\u00f6ndahl", "given": "Jakob", "initials": "J"}, {"family": "Thuresson", "given": "Sara", "initials": "S"}, {"family": "Alsved", "given": "Malin", "initials": "M"}, {"family": "Al-Hunaiti", "given": "Afnan", "initials": "A"}, {"family": "Saksela", "given": "Kalle", "initials": "K"}, {"family": "Aqel", "given": "Hazem", "initials": "H"}, {"family": "Junninen", "given": "Heikki", "initials": "H"}, {"family": "Mahura", "given": "Alexander", "initials": "A"}, {"family": "Kulmala", "given": "Markku", "initials": "M"}], "type": "journal article", "published": "2021-03-12", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "6", "pages": null}, "abstract": "Transmission of respiratory viruses is a complex process involving emission, deposition in the airways, and infection. Inhalation is often the most relevant transmission mode in indoor environments. For severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the risk of inhalation transmission is not yet fully understood. Here, we used an indoor aerosol model combined with a regional inhaled deposited dose model to examine the indoor transport of aerosols from an infected person with novel coronavirus disease (COVID-19) to a susceptible person and assess the potential inhaled dose rate of particles. Two scenarios with different ventilation rates were compared, as well as adult female versus male recipients. Assuming a source strength of 10 viruses/s, in a tightly closed room with poor ventilation (0.5 h -1), the respiratory tract deposited dose rate was 140-350 and 100-260 inhaled viruses/hour for males and females; respectively. With ventilation at 3 h-1 the dose rate was only 30-90 viruses/hour. Correcting for the half-life of SARS-CoV-2 in air, these numbers are reduced by a factor of 1.2-2.2 for poorly ventilated rooms and 1.1-1.4 for well-ventilated rooms. Combined with future determinations of virus emission rates, the size distribution of aerosols containing the virus, and the infectious dose, these results could play an important role in understanding the full picture of potential inhalation transmission in indoor environments.", "doi": "10.3390/ijerph18062927", "pmid": "33809366", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Public Health": null, "Funder: H2020": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pii", "key": "ijerph18062927"}], "notes": [], "created": "2021-04-06T10:28:30.739Z", "modified": "2021-06-18T15:24:59.028Z"}, {"entity": "publication", "iuid": "57b0f4e9731f4829b69f86301d0eb285", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/57b0f4e9731f4829b69f86301d0eb285.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/57b0f4e9731f4829b69f86301d0eb285"}}, "title": "Does reactivation of cytomegalovirus contribute to severe COVID-19 disease?", "authors": [{"family": "S\u00f6derberg-Naucl\u00e9r", "given": "Cecilia", "initials": "C"}], "type": "letter", "published": "2021-03-12", "journal": {"title": "Immun Ageing", "issn": "1742-4933", "volume": "18", "issue": "1", "pages": "12", "issn-l": null}, "abstract": "The majority of people infected with SARS-CoV-2 are asymptomatic or have mild to moderate symptoms. However, for unknown reasons, about 15 % have severe pneumonia requiring hospital care and oxygen support, and about 5 % develop acute respiratory distress syndrome, septic shock, and multiorgan failure that result in a high mortality rate. The risk of severe COVID-19 is highest among those who are over 70 years of age. Why severe COVID-19 develops in some people but not others is not understood. Could some cases involve reactivation of latent cytomegalovirus (CMV)?", "doi": "10.1186/s12979-021-00218-z", "pmid": "33712035", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12979-021-00218-z"}, {"db": "pmc", "key": "PMC7952506"}], "notes": [], "created": "2021-03-17T07:17:39.389Z", "modified": "2021-03-17T07:17:39.410Z"}, {"entity": "publication", "iuid": "0fda30da2de8474d9d7951b107e01343", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0fda30da2de8474d9d7951b107e01343.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0fda30da2de8474d9d7951b107e01343"}}, "title": "Disparities in COVID-19 deaths by country of birth in Stockholm, Sweden: A total population based cohort study.", "authors": [{"family": "Rostila", "given": "Mikael", "initials": "M"}, {"family": "Cederstr\u00f6m", "given": "Agneta", "initials": "A"}, {"family": "Wallace", "given": "Matthew", "initials": "M"}, {"family": "Brand\u00e9n", "given": "Maria", "initials": "M"}, {"family": "Malmberg", "given": "Bo", "initials": "B"}, {"family": "Andersson", "given": "Gunnar", "initials": "G"}], "type": "journal article", "published": "2021-03-12", "journal": {"title": "Am J Epidemiol", "issn": "1476-6256", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Preliminary evidence points to higher morbidity and mortality of COVID-19 in certain racial and ethnic groups but population-based studies using micro-level data are so far lacking. A register-based cohort including all adults living in Stockholm, Sweden (n=1,778,670) between January 31st (date of first confirmed case of COVID-19) and May 4th 2020 was utilized. Poisson regressions with region/country of birth as exposure and underlying cause of death by COVID-19 as outcome was performed, estimating relative risks (RR) and confidence intervals (CI). Migrants from Middle-Eastern countries (RR 3.2, 95% CI: 2.6-3.8), Africa (RR 3.0, 95% CI: 2.2-4.3) and the Nordic countries (RR 1.5, 95% CI: 1.2-1.8) had higher mortality in COVID-19 when compared to Swedish born. Especially high mortality risks from COVID-19 was found among individuals born in Somalia, Lebanon, Syria, Turkey, Iran and Iraq. Socioeconomic status, number of working age household members and neighborhood population density attenuated up to half of the increased COVID-19 mortality risks among foreign born. Disadvantaged socioeconomic and living conditions may increase infection rates in migrants and contribute to their higher COVID-19 mortality risk.", "doi": "10.1093/aje/kwab057", "pmid": "33710317", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6168677"}], "notes": [], "created": "2021-03-17T07:16:08.894Z", "modified": "2021-06-18T15:22:46.753Z"}, {"entity": "publication", "iuid": "ed5b25234cba4f13b74f1d73fda2a894", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed5b25234cba4f13b74f1d73fda2a894.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed5b25234cba4f13b74f1d73fda2a894"}}, "title": "Could a good night's sleep improve COVID-19 vaccine efficacy?", "authors": [{"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J"}], "type": "journal article", "published": "2021-03-12", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "volume": null, "issue": null, "issn-l": "2213-2600"}, "abstract": null, "doi": "10.1016/S2213-2600(21)00126-0", "pmid": "33721558", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(21)00126-0"}], "notes": [], "created": "2021-03-17T07:45:00.431Z", "modified": "2021-03-22T11:44:11.630Z"}, {"entity": "publication", "iuid": "bfc7cd9b29f3455f9279026840d26993", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bfc7cd9b29f3455f9279026840d26993.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bfc7cd9b29f3455f9279026840d26993"}}, "title": "[Tracheotomy earlier than recommended among patients with Covid-19].", "authors": [{"family": "Nihl\u00e9n", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Odhagen", "given": "Erik", "initials": "E"}, {"family": "Lindell", "given": "Ellen", "initials": "E"}], "type": "journal article", "published": "2021-03-11", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "volume": "118", "issue": null, "issn-l": "0023-7205"}, "abstract": "The outbreak of SARS-CoV-2 has led to a sharp rise in intensive care unit (ICU) admissions and consequently a need to perform tracheotomies on patients with Covid-19. A number of guidelines have been published with recommendations for the timing of tracheostomy in Covid-19 patients, suggesting tracheotomy should be delayed until day 14-21 of mechanical ventilation. We present the first 66 patients treated in the ICU at S\u00f6dra \u00c4lvsborg hospital in Sweden as a result of Covid-19. A total of 29 patients received a tracheostomy, median time 9 days post oral intubation, which is earlier than recommended. The mortality rate was 21%, which is slightly lower than reported from The Swedish Intensive Care Registry (25%). None of the doctors performing tracheotomies developed Covid-19 linked to the tracheotomy procedure.", "doi": null, "pmid": "33709387", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "20232"}], "notes": [], "created": "2021-03-17T07:18:22.056Z", "modified": "2021-03-17T07:41:15.135Z"}, {"entity": "publication", "iuid": "08edf7c7a48448198e50b7c786f8cb50", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/08edf7c7a48448198e50b7c786f8cb50.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/08edf7c7a48448198e50b7c786f8cb50"}}, "title": "The battle for COVID-19 vaccines highlights the need for a new global governance mechanism.", "authors": [{"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM"}, {"family": "Berggren", "given": "Camilla", "initials": "C"}, {"family": "Tomson", "given": "G\u00f6ran", "initials": "G"}, {"family": "Gostin", "given": "Lawrence O", "initials": "LO"}, {"family": "Friberg", "given": "Peter", "initials": "P"}, {"family": "Ottersen", "given": "Ole Petter", "initials": "OP"}], "type": "letter", "published": "2021-03-11", "journal": {"title": "Nat Med", "issn": "1546-170X", "volume": null, "issue": null, "issn-l": "1078-8956"}, "abstract": null, "doi": "10.1038/s41591-021-01288-8", "pmid": "33707776", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-021-01288-8"}], "notes": [], "created": "2021-03-17T07:20:39.660Z", "modified": "2021-03-17T07:20:39.669Z"}, {"entity": "publication", "iuid": "de451ac94d164bf5b45bf034a5c04d1c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/de451ac94d164bf5b45bf034a5c04d1c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/de451ac94d164bf5b45bf034a5c04d1c"}}, "title": "Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers.", "authors": [{"family": "Danlos", "given": "Fran\u00e7ois-Xavier", "initials": "FX"}, {"family": "Grajeda-Iglesias", "given": "Claudia", "initials": "C"}, {"family": "Durand", "given": "Sylv\u00e8re", "initials": "S"}, {"family": "Sauvat", "given": "Allan", "initials": "A"}, {"family": "Roumier", "given": "Mathilde", "initials": "M"}, {"family": "Cantin", "given": "Delphine", "initials": "D"}, {"family": "Colomba", "given": "Emeline", "initials": "E"}, {"family": "Rohmer", "given": "Julien", "initials": "J"}, {"family": "Pommeret", "given": "Fanny", "initials": "F"}, {"family": "Baciarello", "given": "Giulia", "initials": "G"}, {"family": "Willekens", "given": "Christophe", "initials": "C"}, {"family": "Vasse", "given": "Marc", "initials": "M"}, {"family": "Griscelli", "given": "Frank", "initials": "F"}, {"family": "Fahrner", "given": "Jean-Eudes", "initials": "JE"}, {"family": "Goubet", "given": "Anne-Ga\u00eblle", "initials": "AG"}, {"family": "Dubuisson", "given": "Agathe", "initials": "A"}, {"family": "Derosa", "given": "Lisa", "initials": "L"}, {"family": "Nirmalathasan", "given": "Nitharsshini", "initials": "N"}, {"family": "Bredel", "given": "Delphine", "initials": "D"}, {"family": "Mouraud", "given": "S\u00e9verine", "initials": "S"}, {"family": "Pradon", "given": "Caroline", "initials": "C"}, {"family": "Stoclin", "given": "Annabelle", "initials": "A"}, {"family": "Rozenberg", "given": "Flore", "initials": "F"}, {"family": "Duchemin", "given": "J\u00e9r\u00f4me", "initials": "J"}, {"family": "Jourdi", "given": "Georges", "initials": "G"}, {"family": "Ellouze", "given": "Syrine", "initials": "S"}, {"family": "Levavasseur", "given": "Fran\u00e7oise", "initials": "F"}, {"family": "Albig\u00e8s", "given": "Laurence", "initials": "L"}, {"family": "Soria", "given": "Jean-Charles", "initials": "JC"}, {"family": "Barlesi", "given": "Fabrice", "initials": "F"}, {"family": "Solary", "given": "Eric", "initials": "E"}, {"family": "Andr\u00e9", "given": "Fabrice", "initials": "F"}, {"family": "P\u00e8ne", "given": "Fr\u00e9d\u00e9ric", "initials": "F"}, {"family": "Ackerman", "given": "F\u00e9lix", "initials": "F"}, {"family": "Mouthon", "given": "Luc", "initials": "L"}, {"family": "Zitvogel", "given": "Laurence", "initials": "L"}, {"family": "Marabelle", "given": "Aur\u00e9lien", "initials": "A"}, {"family": "Michot", "given": "Jean-Marie", "initials": "JM"}, {"family": "Fontenay", "given": "Michaela", "initials": "M"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}], "type": "journal article", "published": "2021-03-11", "journal": {"title": "Cell Death Dis", "issn": "2041-4889", "volume": "12", "issue": "3", "pages": "258", "issn-l": null}, "abstract": "The circulating metabolome provides a snapshot of the physiological state of the organism responding to pathogenic challenges. Here we report alterations in the plasma metabolome reflecting the clinical presentation of COVID-19 patients with mild (ambulatory) diseases, moderate disease (radiologically confirmed pneumonitis, hospitalization and oxygen therapy), and critical disease (in intensive care). This analysis revealed major disease- and stage-associated shifts in the metabolome, meaning that at least 77 metabolites including amino acids, lipids, polyamines and sugars, as well as their derivatives, were altered in critical COVID-19 patient's plasma as compared to mild COVID-19 patients. Among a uniformly moderate cohort of patients who received tocilizumab, only 10 metabolites were different among individuals with a favorable evolution as compared to those who required transfer into the intensive care unit. The elevation of one single metabolite, anthranilic acid, had a poor prognostic value, correlating with the maintenance of high interleukin-10 and -18 levels. Given that products of the kynurenine pathway including anthranilic acid have immunosuppressive properties, we speculate on the therapeutic utility to inhibit the rate-limiting enzymes of this pathway including indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase.", "doi": "10.1038/s41419-021-03540-y", "pmid": "33707411", "labels": {"Category: Drug Discovery": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41419-021-03540-y"}, {"db": "pmc", "key": "PMC7948172"}, {"db": "URL", "key": "https://doi.org/10.1038/s41419-021-03540-y", "description": "All metabolomics data (supplementary tables)"}], "notes": [], "created": "2021-03-17T07:10:40.858Z", "modified": "2021-11-18T13:09:56.552Z"}, {"entity": "publication", "iuid": "910730ae686542e69773578ef3922045", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/910730ae686542e69773578ef3922045.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/910730ae686542e69773578ef3922045"}}, "title": "Interventions for treatment of COVID-19: Second edition of a living systematic review with meta-analyses and trial sequential analyses (The LIVING Project).", "authors": [{"family": "Juul", "given": "Sophie", "initials": "S"}, {"family": "Nielsen", "given": "Emil Eik", "initials": "EE"}, {"family": "Feinberg", "given": "Joshua", "initials": "J"}, {"family": "Siddiqui", "given": "Faiza", "initials": "F"}, {"family": "J\u00f8rgensen", "given": "Caroline Kamp", "initials": "CK"}, {"family": "Barot", "given": "Emily", "initials": "E"}, {"family": "Holgersson", "given": "Johan", "initials": "J"}, {"family": "Nielsen", "given": "Niklas", "initials": "N"}, {"family": "Bentzer", "given": "Peter", "initials": "P"}, {"family": "Veroniki", "given": "Areti Angeliki", "initials": "AA"}, {"family": "Thabane", "given": "Lehana", "initials": "L"}, {"family": "Bu", "given": "Fanlong", "initials": "F"}, {"family": "Klingenberg", "given": "Sarah", "initials": "S"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Jakobsen", "given": "Janus Christian", "initials": "JC"}], "type": "journal article", "published": "2021-03-11", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "3", "pages": "e0248132", "issn-l": "1932-6203"}, "abstract": "COVID-19 is a rapidly spreading disease that has caused extensive burden to individuals, families, countries, and the world. Effective treatments of COVID-19 are urgently needed. This is the second edition of a living systematic review of randomized clinical trials assessing the effects of all treatment interventions for participants in all age groups with COVID-19.\n\nWe planned to conduct aggregate data meta-analyses, trial sequential analyses, network meta-analysis, and individual patient data meta-analyses. Our systematic review was based on PRISMA and Cochrane guidelines, and our eight-step procedure for better validation of clinical significance of meta-analysis results. We performed both fixed-effect and random-effects meta-analyses. Primary outcomes were all-cause mortality and serious adverse events. Secondary outcomes were admission to intensive care, mechanical ventilation, renal replacement therapy, quality of life, and non-serious adverse events. According to the number of outcome comparisons, we adjusted our threshold for significance to p = 0.033. We used GRADE to assess the certainty of evidence. We searched relevant databases and websites for published and unpublished trials until November 2, 2020. Two reviewers independently extracted data and assessed trial methodology. We included 82 randomized clinical trials enrolling a total of 40,249 participants. 81 out of 82 trials were at overall high risk of bias. Meta-analyses showed no evidence of a difference between corticosteroids versus control on all-cause mortality (risk ratio [RR] 0.89; 95% confidence interval [CI] 0.79 to 1.00; p = 0.05; I2 = 23.1%; eight trials; very low certainty), on serious adverse events (RR 0.89; 95% CI 0.80 to 0.99; p = 0.04; I2 = 39.1%; eight trials; very low certainty), and on mechanical ventilation (RR 0.86; 95% CI 0.55 to 1.33; p = 0.49; I2 = 55.3%; two trials; very low certainty). The fixed-effect meta-analyses showed indications of beneficial effects. Trial sequential analyses showed that the required information size for all three analyses was not reached. Meta-analysis (RR 0.93; 95% CI 0.82 to 1.07; p = 0.31; I2 = 0%; four trials; moderate certainty) and trial sequential analysis (boundary for futility crossed) showed that we could reject that remdesivir versus control reduced the risk of death by 20%. Meta-analysis (RR 0.82; 95% CI 0.68 to 1.00; p = 0.05; I2 = 38.9%; four trials; very low certainty) and trial sequential analysis (required information size not reached) showed no evidence of difference between remdesivir versus control on serious adverse events. Fixed-effect meta-analysis showed indications of a beneficial effect of remdesivir on serious adverse events. Meta-analysis (RR 0.40; 95% CI 0.19 to 0.87; p = 0.02; I2 = 0%; two trials; very low certainty) showed evidence of a beneficial effect of intravenous immunoglobulin versus control on all-cause mortality, but trial sequential analysis (required information size not reached) showed that the result was severely underpowered to confirm or reject realistic intervention effects. Meta-analysis (RR 0.63; 95% CI 0.35 to 1.14; p = 0.12; I2 = 77.4%; five trials; very low certainty) and trial sequential analysis (required information size not reached) showed no evidence of a difference between tocilizumab versus control on serious adverse events. Fixed-effect meta-analysis showed indications of a beneficial effect of tocilizumab on serious adverse events. Meta-analysis (RR 0.70; 95% CI 0.51 to 0.96; p = 0.02; I2 = 0%; three trials; very low certainty) showed evidence of a beneficial effect of tocilizumab versus control on mechanical ventilation, but trial sequential analysis (required information size not reached) showed that the result was severely underpowered to confirm of reject realistic intervention effects. Meta-analysis (RR 0.32; 95% CI 0.15 to 0.69; p < 0.00; I2 = 0%; two trials; very low certainty) showed evidence of a beneficial effect of bromhexine versus standard care on non-serious adverse events, but trial sequential analysis (required information size not reached) showed that the result was severely underpowered to confirm or reject realistic intervention effects. Meta-analyses and trial sequential analyses (boundary for futility crossed) showed that we could reject that hydroxychloroquine versus control reduced the risk of death and serious adverse events by 20%. Meta-analyses and trial sequential analyses (boundary for futility crossed) showed that we could reject that lopinavir-ritonavir versus control reduced the risk of death, serious adverse events, and mechanical ventilation by 20%. All remaining outcome comparisons showed that we did not have enough information to confirm or reject realistic intervention effects. Nine single trials showed statistically significant results on our outcomes, but were underpowered to confirm or reject realistic intervention effects. Due to lack of data, it was not relevant to perform network meta-analysis or possible to perform individual patient data meta-analyses.\n\nNo evidence-based treatment for COVID-19 currently exists. Very low certainty evidence indicates that corticosteroids might reduce the risk of death, serious adverse events, and mechanical ventilation; that remdesivir might reduce the risk of serious adverse events; that intravenous immunoglobin might reduce the risk of death and serious adverse events; that tocilizumab might reduce the risk of serious adverse events and mechanical ventilation; and that bromhexine might reduce the risk of non-serious adverse events. More trials with low risks of bias and random errors are urgently needed. This review will continuously inform best practice in treatment and clinical research of COVID-19.\n\nPROSPERO CRD42020178787.", "doi": "10.1371/journal.pone.0248132", "pmid": "33705495", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-38879"}], "notes": [], "created": "2021-03-12T07:06:25.255Z", "modified": "2021-03-12T07:06:25.266Z"}, {"entity": "publication", "iuid": "e4441b5f42514f278ec262f36dd23c9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e4441b5f42514f278ec262f36dd23c9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e4441b5f42514f278ec262f36dd23c9c"}}, "title": "Awake Proning as an Adjunctive Therapy for Refractory Hypoxemia in Non-Intubated Patients with COVID-19 Acute Respiratory Failure: Guidance from an International Group of Healthcare Workers.", "authors": [{"family": "Stilma", "given": "Willemke", "initials": "W"}, {"family": "\u00c5kerman", "given": "Eva", "initials": "E"}, {"family": "Artigas", "given": "Antonio", "initials": "A"}, {"family": "Bentley", "given": "Andrew", "initials": "A"}, {"family": "Bos", "given": "Lieuwe D", "initials": "LD"}, {"family": "Bosman", "given": "Thomas J C", "initials": "TJC"}, {"family": "de Bruin", "given": "Hendrik", "initials": "H"}, {"family": "Brummaier", "given": "Tobias", "initials": "T"}, {"family": "Buiteman-Kruizinga", "given": "Laura A", "initials": "LA"}, {"family": "Carc\u00f2", "given": "Francesco", "initials": "F"}, {"family": "Chesney", "given": "Gregg", "initials": "G"}, {"family": "Chu", "given": "Cindy", "initials": "C"}, {"family": "Dark", "given": "Paul", "initials": "P"}, {"family": "Dondorp", "given": "Arjen M", "initials": "AM"}, {"family": "Gijsbers", "given": "Harm J H", "initials": "HJH"}, {"family": "Gilder", "given": "Mary Ellen", "initials": "ME"}, {"family": "Grieco", "given": "Domenico L", "initials": "DL"}, {"family": "Inglis", "given": "Rebecca", "initials": "R"}, {"family": "Laffey", "given": "John G", "initials": "JG"}, {"family": "Landoni", "given": "Giovanni", "initials": "G"}, {"family": "Lu", "given": "Weihua", "initials": "W"}, {"family": "Maduro", "given": "Lisa M N", "initials": "LMN"}, {"family": "McGready", "given": "Rose", "initials": "R"}, {"family": "McNicholas", "given": "Bairbre", "initials": "B"}, {"family": "de Mendoza", "given": "Diego", "initials": "D"}, {"family": "Morales-Quinteros", "given": "Luis", "initials": "L"}, {"family": "Nosten", "given": "Francois", "initials": "F"}, {"family": "Papali", "given": "Alfred", "initials": "A"}, {"family": "Paternoster", "given": "Gianluca", "initials": "G"}, {"family": "Paulus", "given": "Frederique", "initials": "F"}, {"family": "Pisani", "given": "Luigi", "initials": "L"}, {"family": "Prud'homme", "given": "Eloi", "initials": "E"}, {"family": "Ricard", "given": "Jean-Damien", "initials": "JD"}, {"family": "Roca", "given": "Oriol", "initials": "O"}, {"family": "Sartini", "given": "Chiara", "initials": "C"}, {"family": "Scaravilli", "given": "Vittorio", "initials": "V"}, {"family": "Schultz", "given": "Marcus J", "initials": "MJ"}, {"family": "Sivakorn", "given": "Chaisith", "initials": "C"}, {"family": "Spronk", "given": "Peter E", "initials": "PE"}, {"family": "Sztajnbok", "given": "Jaques", "initials": "J"}, {"family": "Trigui", "given": "Youssef", "initials": "Y"}, {"family": "Vollman", "given": "Kathleen M", "initials": "KM"}, {"family": "van der Woude", "given": "Margaretha C E", "initials": "MCE"}], "type": "journal article", "published": "2021-03-11", "journal": {"title": "Am J Trop Med Hyg", "issn": "1476-1645", "volume": null, "issue": null, "issn-l": "0002-9637"}, "abstract": "Non-intubated patients with acute respiratory failure due to COVID-19 could benefit from awake proning. Awake proning is an attractive intervention in settings with limited resources, as it comes with no additional costs. However, awake proning remains poorly used probably because of unfamiliarity and uncertainties regarding potential benefits and practical application. To summarize evidence for benefit and to develop a set of pragmatic recommendations for awake proning in patients with COVID-19 pneumonia, focusing on settings where resources are limited, international healthcare professionals from high and low- and middle-income countries (LMICs) with known expertise in awake proning were invited to contribute expert advice. A growing number of observational studies describe the effects of awake proning in patients with COVID-19 pneumonia in whom hypoxemia is refractory to simple measures of supplementary oxygen. Awake proning improves oxygenation in most patients, usually within minutes, and reduces dyspnea and work of breathing. The effects are maintained for up to 1 hour after turning back to supine, and mostly disappear after 6-12 hours. In available studies, awake proning was not associated with a reduction in the rate of intubation for invasive ventilation. Awake proning comes with little complications if properly implemented and monitored. Pragmatic recommendations including indications and contraindications were formulated and adjusted for resource-limited settings. Awake proning, an adjunctive treatment for hypoxemia refractory to supplemental oxygen, seems safe in non-intubated patients with COVID-19 acute respiratory failure. We provide pragmatic recommendations including indications and contraindications for the use of awake proning in LMICs.", "doi": "10.4269/ajtmh.20-1445", "pmid": "33705348", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "tpmd201445"}, {"db": "pmc", "key": "PMC8103477"}], "notes": [], "created": "2021-03-12T07:05:39.237Z", "modified": "2021-11-18T12:57:03.738Z"}, {"entity": "publication", "iuid": "02ac2f6d92cb43919788a8738c0d2c7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02ac2f6d92cb43919788a8738c0d2c7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02ac2f6d92cb43919788a8738c0d2c7a"}}, "title": "Analysis of the early COVID-19 epidemic curve in Germany by regression models with change points.", "authors": [{"family": "K\u00fcchenhoff", "given": "Helmut", "initials": "H"}, {"family": "G\u00fcnther", "given": "Felix", "initials": "F"}, {"family": "H\u00f6hle", "given": "Michael", "initials": "M"}, {"family": "Bender", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2021-03-11", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "issn-l": null, "volume": null, "issue": null, "pages": "1-17"}, "abstract": null, "doi": "10.1017/S0950268821000558", "pmid": "33691815", "labels": {"Category: Public Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0950268821000558"}], "notes": [], "created": "2021-03-12T06:11:13.310Z", "modified": "2021-06-18T15:03:05.817Z"}, {"entity": "publication", "iuid": "506375d9c20e4838a66749414bb9fd7f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/506375d9c20e4838a66749414bb9fd7f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/506375d9c20e4838a66749414bb9fd7f"}}, "title": "Dangerous liaisons: an online experiment on the role of scientific experts and politicians in ensuring public support for anti-COVID measures.", "authors": [{"family": "Farjam", "given": "Mike", "initials": "M"}, {"family": "Bianchi", "given": "Federico", "initials": "F"}, {"family": "Squazzoni", "given": "Flaminio", "initials": "F"}, {"family": "Bravo", "given": "Giangiacomo", "initials": "G"}], "type": "journal article", "published": "2021-03-10", "journal": {"title": "R Soc Open Sci", "issn": "2054-5703", "volume": "8", "issue": "3", "pages": "201310", "issn-l": null}, "abstract": "The effectiveness of public health measures to prevent COVID-19 contagion has required less vulnerable citizens to pay an individual cost in terms of personal liberty infringement to protect more vulnerable groups. However, the close relationship between scientific experts and politicians in providing information on COVID-19 measures makes it difficult to understand which communication source was more effective in increasing pro-social behaviour. Here, we present an online experiment performed in May 2020, during the first wave of the pandemic on 1131 adult residents in Lombardy, Italy, one of the world's hardest hit regions. Results showed that when scientific experts recommended anti-contagion measures, participants were more sensitive to pro-social motivations, unlike whenever these measures were recommended by politicians and scientific experts together. Our findings suggest the importance of trusted sources in public communication during a pandemic.", "doi": "10.1098/rsos.201310", "pmid": "33959315", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "rsos201310"}, {"db": "pmc", "key": "PMC8074882"}], "notes": [], "created": "2021-05-17T19:07:13.485Z", "modified": "2021-05-17T19:07:13.496Z"}, {"entity": "publication", "iuid": "7eb3ba1ca5864d3e8b7a01c85b5ca3ac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7eb3ba1ca5864d3e8b7a01c85b5ca3ac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7eb3ba1ca5864d3e8b7a01c85b5ca3ac"}}, "title": "COVID-19 Antibody Testing of Patients Admitted to the ICU by a Novel, Point-of-Care Assay, and the Relationship to Survival", "authors": [{"family": "Casswell", "given": "Stacey", "initials": "S"}, {"family": "Eriksson", "given": "Ann Katrin", "initials": "AK"}, {"family": "Moberg", "given": "Lena", "initials": "L"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Marshall", "given": "Fiona", "initials": "F"}, {"family": "Venge", "given": "Per", "initials": "P"}], "type": "posted-content", "published": "2021-03-10", "journal": {"title": "Research Square", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Diagnosing persons infected by COVID-19 is key to the control of the pandemic. It has, however, become increasingly important to identify those who have had the infection by measurement of circulating antibodies against Sars-COV-2 of the IgM and IgG type. In this report we show the development of a rapid and sensitive point-of-care assay for the measurement of IgG antibodies against the two spike proteins, S1 and S2, of the Sars-COV-2 virus.\r\nMethod\r\nThe AgPlus electrochemical technology was applied and the S1 and S2 proteins were biotinylated and immobilized onto streptavidin coated magnetic particles as the capture component of the assay. The IgG antibodies bound to the particles were detected by anti-human IgG and the signal expressed as nC (nano Coulomb). Assay time was <10 min.\r\nResults\r\nPlasma (n=211) from 117 SARS-Cov-2 PCR positive patients and from 78 persons with samples taken before the COVID-19 pandemic were analysed. The sensitivity and specificity of the assay were 91.9% and 100%, respectively. The assay was highly correlated to a predicate and FDA-approved IgG antibody ELISA (r=0.81). The IgG response was significantly lower in patients who died during their ICU stay.\r\nConclusions\r\nA poor IgG response after a COVID-19 infection is a serious risk factor as to death. A sensitive, rapid and accurate IgG antibody POC assay should be useful in the daily management and evaluation of COVID-19 infected patients.", "doi": "10.21203/rs.3.rs-289303/v1", "pmid": null, "labels": {"Category: Proteins": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Preprint": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT04316884", "description": null}], "notes": [], "created": "2021-03-16T07:15:17.244Z", "modified": "2021-05-06T05:38:49.997Z"}, {"entity": "publication", "iuid": "dda2feafd8ce45c5b77c4b517d6b0d07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dda2feafd8ce45c5b77c4b517d6b0d07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dda2feafd8ce45c5b77c4b517d6b0d07"}}, "title": "Recommendations for the use of COVID-19 vaccines in patients with immune-mediated kidney diseases.", "authors": [{"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Anders", "given": "Hans-Joachim", "initials": "HJ"}, {"family": "Fernandez-Ju\u00e1rez", "given": "Gema Maria", "initials": "GM"}, {"family": "Floege", "given": "J\u00fcrgen", "initials": "J"}, {"family": "Goumenos", "given": "Dimitrios", "initials": "D"}, {"family": "Segelmark", "given": "M\u00e5rten", "initials": "M"}, {"family": "Tesar", "given": "Vladimir", "initials": "V"}, {"family": "Turkmen", "given": "Kultigin", "initials": "K"}, {"family": "van Kooten", "given": "Cees", "initials": "C"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Immunonephrology Working Group of the ERA-EDTA (European Renal Association \u2013 European Dialysis, Transplant Association)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-03-09", "journal": {"title": "Nephrol Dial Transplant", "issn": "1460-2385", "volume": null, "issue": null, "issn-l": "0931-0509"}, "abstract": "Coronavirus Disease 19 (COVID-19) vaccine platforms are becoming available and are the most promising strategy to curb the spread of SARS-CoV-2 infections. However, numerous uncertainties exist regarding the pros and cons of vaccination, especially in patients with (immune-mediated) kidney diseases on immunosuppressive drugs. Here, members of the Immunonephrology Working Group (IWG) of the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) discuss thirteen frequently-asked questions regarding safety and efficacy of the most promising vaccine candidates. Post-marketing surveillance should be performed to estimate the rate of vaccine response (humoral and cellular) of different vaccine platforms, and surveillance of disease activity following administration of COVID-19 vaccines. Some of the candidates induce signaling pathways which also promote autoimmune kidney diseases, e.g. type I interferons in systemic lupus erythematosus. Efficacy estimates would thus far favor the use of selected COVID-19 vaccines, such as BNT162b2, mRNA-1273 or Gam-COVID-Vac. Humoral immune response after vaccination should be monitored using appropriate assays. Even in the absence of neutralizing antibodies patients might be protected by a sufficient cellular immune response capable to reduce severity of COVID-19. A reduced vaccine response after the use of CD20-depleting agents is anticipated, and it is particularly important to discuss strategies to improve vaccine response with these patients. Distancing and shielding measures remain important as not all vaccines fully protect from coronavirus infection. In-depth information about the most pressing vaccine questions is essential to reduce vaccine hesitancy of patients.", "doi": "10.1093/ndt/gfab064", "pmid": "33693778", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6163301"}, {"db": "pmc", "key": "PMC7989374"}], "notes": [], "created": "2021-03-12T06:41:55.287Z", "modified": "2021-11-18T12:53:07.877Z"}, {"entity": "publication", "iuid": "65b3cf84cf1c4adabcf5084d92f886fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65b3cf84cf1c4adabcf5084d92f886fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65b3cf84cf1c4adabcf5084d92f886fd"}}, "title": "Association between SARS-CoV-2 and exposure risks in health care workers and university employees - a cross-sectional study.", "authors": [{"family": "Nygren", "given": "David", "initials": "D"}, {"family": "Nor\u00e9n", "given": "Jonas", "initials": "J"}, {"family": "De Marinis", "given": "Yang", "initials": "Y"}, {"family": "Holmberg", "given": "Anna", "initials": "A"}, {"family": "Fraenkel", "given": "Carl-Johan", "initials": "C"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-03-09", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": null, "issue": null, "pages": "1-9"}, "abstract": "In health care workers SARS-CoV-2 has been shown to be an occupational health risk, often associated with transmission between health care workers. Yet, insufficient information on transmission dynamics has been presented to elucidate the precise risk factors for contracting SARS-CoV-2 in this group.\r\n\r\nIn this cross-sectional study, we investigated association between questionnaire answers on potential exposure situations and SARS-CoV-2-positivity. Health care workers with and without COVID-19-patient contact at nine units at Sk\u00e5ne University Hospitals in Malm\u00f6 and Lund, Sweden and university employees from Lund University, Sweden were enrolled. To limit impact of health care worker to health care worker transmission, units with known outbreaks were excluded. A SARS-CoV-2-positive case was defined by a previous positive PCR or anti-SARS-CoV-2 IgG in the ZetaGene COVID-19 Antibody Test.\r\n\r\nSARS-CoV-2-positivity was detected in 11/51 (22%) health care workers in COVID-19-units, 10/220 (5%) in non-COVID-19-units and 11/192 (6%) University employees ( p = .001, Fischer's exact). In health care workers, SARS-CoV-2-positivity was associated with work in a designated COVID-19-unit (OR 5.7 (95CI 2.1-16)) and caring for COVID-19-patients during the majority of shifts (OR 5.4 (95CI 2.0-15)). In all participants, SARS-CoV-2-positivity was associated with a confirmed COVID-19 case (OR 10 (95CI 2.0-45)) in the household.\r\n\r\nOur study confirmed previous findings of elevated risk of acquiring SARS-CoV-2 in health care workers in COVID-19-units, despite exclusion of units with known outbreaks. Interestingly, health care workers in non-COVID-19-units had similar risk as University employees. Further measures to improve the safety of health care workers might be needed.KEY POINTSPrevious findings of elevated risk of contracting SARS-CoV-2 in health care workers with COVID-19 patient contact was confirmed, despite exclusion of wards with known SARS-CoV-2 outbreaks. Further measures to improve the safety of health care workers might be needed.", "doi": "10.1080/23744235.2021.1892819", "pmid": "33689558", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-12T06:06:56.943Z", "modified": "2021-06-18T14:49:02.100Z"}, {"entity": "publication", "iuid": "df4389825bde4d01ad2e227a293a4a1b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/df4389825bde4d01ad2e227a293a4a1b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/df4389825bde4d01ad2e227a293a4a1b"}}, "title": "Assessing relative COVID-19 mortality: a Swiss population-based study.", "authors": [{"family": "Hothorn", "given": "Torsten", "initials": "T"}, {"family": "Bopp", "given": "Matthias", "initials": "M"}, {"family": "G\u00fcnthard", "given": "Huldrych", "initials": "H"}, {"family": "Keiser", "given": "Olivia", "initials": "O"}, {"family": "Roelens", "given": "Maroussia", "initials": "M"}, {"family": "Weibull", "given": "Caroline E", "initials": "CE"}, {"family": "Crowther", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2021-03-08", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "3", "pages": "e042387", "issn-l": "2044-6055"}, "abstract": "Severity of the COVID-19 has been previously reported in terms of absolute mortality in SARS-CoV-2 positive cohorts. An assessment of mortality relative to mortality in the general population is presented.\n\nRetrospective population-based study.\n\nIndividual information on symptomatic confirmed SARS-CoV-2 patients and subsequent deaths from any cause were compared with the all-cause mortality in the Swiss population of 2018. Starting 23 February 2020, mortality in COVID-19 patients was monitored for 80 days and compared with the population mortality observed in the same time of year starting 23 February 2018.\n\n5 102 300 inhabitants of Switzerland aged 35-95 without COVID-19 (general population in spring 2018) and 20 769 persons tested positively for COVID-19 during the first wave in spring 2020.\n\nSex-specific and age-specific mortality rates were estimated using Cox proportional hazards models. Absolute probabilities of death were predicted and risk was assessed in terms of relative mortality by taking the ratio between the sex-specific and age-specific absolute mortality in COVID-19 patients and the corresponding mortality in the 2018 general population.\n\nAbsolute mortalities increased with age and were higher for males compared with females, both in the general population and in positively tested persons. A confirmed SARS-CoV-2 infection substantially increased the probability of death across all patient groups at least eightfold. The highest relative mortality risks were observed among males and younger patients. Male COVID-19 patients exceeded the population hazard for males (HR 1.21, 95% CI 1.02 to 1.44). An additional year of age increased the population hazard in COVID-19 patients only marginally (HR 1.00, 95% CI 1.00 to 1.01).\n\nHealthcare professionals, decision-makers and societies are provided with an additional population-adjusted assessment of COVID-19 mortality risk. In combination with absolute measures of risk, the relative risks presented here help to develop a more comprehensive understanding of the actual impact of COVID-19.", "doi": "10.1136/bmjopen-2020-042387", "pmid": "34006026", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-042387"}, {"db": "URL", "key": "https://gitlab.switch.ch/torsten.hothorn/relative_covid-19_mortality", "description": "Data, R and Stata code"}], "notes": [], "created": "2021-05-20T14:50:19.838Z", "modified": "2021-11-19T11:39:40.055Z"}, {"entity": "publication", "iuid": "abdd36ff54f448bb8c50ab2769484a66", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abdd36ff54f448bb8c50ab2769484a66.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abdd36ff54f448bb8c50ab2769484a66"}}, "title": "Digital health and COVID-19: challenges of use and implementation in sub-Saharan Africa.", "authors": [{"family": "Mogessie", "given": "Yidnekachew Girma", "initials": "YG"}, {"family": "Ntacyabukura", "given": "Blaise", "initials": "B"}, {"family": "Mengesha", "given": "Dawit Tesfagiorgis", "initials": "DT"}, {"family": "Musa", "given": "Mohamed Babiker", "initials": "MB"}, {"family": "Wangari", "given": "Marie-Claire", "initials": "MC"}, {"family": "Claude", "given": "Nsabimana", "initials": "N"}, {"family": "Buntongyi", "given": "Nit", "initials": "N"}, {"family": "Lucero-Prisno", "given": "Don Eliseo", "initials": "DE"}], "type": "journal article", "published": "2021-03-07", "journal": {"title": "Pan Afr Med J", "issn": "1937-8688", "volume": "38", "issue": null, "pages": "240", "issn-l": null}, "abstract": "COVID-19 is a global health emergency that exposed the gaps in health systems globally, especially in sub-Saharan Africa home to many fragile healthcare systems and a region beset with a large burden of disease. Various mitigation strategies have been put in place to stop the spread of COVID-19 and management of patients in sub-Saharan Africa. However, much still need to be done. Digital health provides the promise for the continent to bridge the gap in decreasing the negative impact of COVID-19 and effectively mitigate the pandemic. This commentary argues how countries in sub-Saharan Africa need to embrace the use of digital health in public health interventions to vigorously mitigate the COVID-19 pandemic and to contribute towards attaining universal health coverage (UHC).", "doi": "10.11604/pamj.2021.38.240.27948", "pmid": "34046143", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PAMJ-38-240"}, {"db": "pmc", "key": "PMC8140728"}], "notes": [], "created": "2021-05-29T15:23:16.329Z", "modified": "2021-05-29T16:28:47.779Z"}, {"entity": "publication", "iuid": "9e8e161c43634d88b5d5a60fdaa4cbd5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9e8e161c43634d88b5d5a60fdaa4cbd5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9e8e161c43634d88b5d5a60fdaa4cbd5"}}, "title": "Understanding COVID-19 through adverse outcome pathways - 2nd CIAO AOP Design Workshop.", "authors": [{"family": "Wittwehr", "given": "Clemens", "initials": "C"}, {"family": "Amorim", "given": "Maria Jo\u00e3o", "initials": "MJ"}, {"family": "Clerbaux", "given": "Laure-Alix", "initials": "LA"}, {"family": "Krebs", "given": "Catharine", "initials": "C"}, {"family": "Landesmann", "given": "Brigitte", "initials": "B"}, {"family": "Macmillan", "given": "Donna", "initials": "D"}, {"family": "Nymark", "given": "Penny", "initials": "P"}, {"family": "Ram", "given": "Rebecca", "initials": "R"}, {"family": "Garcia-Reyero", "given": "Nat\u00e0lia", "initials": "N"}, {"family": "Sachana", "given": "Magdalini", "initials": "M"}, {"family": "Sullivan", "given": "Kristie", "initials": "K"}, {"family": "Sund", "given": "Jukka", "initials": "J"}, {"family": "Willett", "given": "Catharine", "initials": "C"}], "type": "editorial", "published": "2021-03-05", "journal": {"title": "ALTEX", "issn": "1868-596X", "volume": null, "issue": null, "issn-l": null}, "abstract": "The CIAO project (Modelling the Pathogenesis of COVID\u201119 using the Adverse Outcome Pathway framework) aims at a holistic assembly of knowledge to deliver a truly transdisciplinary description of the entire COVID\u201119 physiopathology starting with the initial contact with the SARS\u2011CoV\u201119 virus and ending with one or several adverse outcomes, e.g., respiratory failure. On 27\u201128 January 2021, a group of 50+ scientists from numerous organizations around the world met in the 2nd CIAO AOP Design Workshop to discuss the depiction of the COVID\u201119 disease process as a series of key events (KEs) in a network of AOPs. During the workshop, 74 such KEs forming 13 AOPs were identified, covering COVID\u201119 manifestations that affect the respiratory, neurological, liver, cardiovascular, kidney and gastrointestinal systems. Modulating factors influencing the course and severity of the disease were also addressed, as was a possible extension of the investigations beyond purely biological phenomena. The workshop ended with the creation of seven working groups, which will further elaborate on the AOPs to be presented and discussed in the 3rd CIAO workshop on 28-29 April 2021.", "doi": "10.14573/altex.2102221", "pmid": "33677612", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-03-09T06:27:27.194Z", "modified": "2021-03-09T06:28:05.358Z"}, {"entity": "publication", "iuid": "ef735d339af4451b8855e6175b157d6b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef735d339af4451b8855e6175b157d6b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef735d339af4451b8855e6175b157d6b"}}, "title": "The emergence and ongoing convergent evolution of the N501Y lineages coincides with a major global shift in the SARS-CoV-2 selective landscape", "authors": [{"family": "Martin", "given": "Darren P", "initials": "DP"}, {"family": "Weaver", "given": "Steven", "initials": "S"}, {"family": "Tegally", "given": "Houryiah", "initials": "H"}, {"family": "San", "given": "Emmanuel James", "initials": "EJ"}, {"family": "Shank", "given": "Stephen D", "initials": "SD"}, {"family": "Wilkinson", "given": "Eduan", "initials": "E"}, {"family": "Giandhari", "given": "Jennifer", "initials": "J"}, {"family": "Naidoo", "given": "Sureshnee", "initials": "S"}, {"family": "Pillay", "given": "Yeshnee", "initials": "Y"}, {"family": "Singh", "given": "Lavanya", "initials": "L"}, {"family": "Lessells", "given": "Richard J", "initials": "RJ"}, {"family": "Gupta", "given": "Ravindra K", "initials": "RK"}, {"family": "Wertheim", "given": "Joel O", "initials": "JO"}, {"family": "Nekturenko", "given": "Anton", "initials": "A"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Harkins", "given": "Gordon W", "initials": "GW"}, {"family": "Lemey", "given": "Philippe", "initials": "P"}, {"family": "MacLean", "given": "Oscar A", "initials": "OA"}, {"family": "Robertson", "given": "David L", "initials": "DL"}, {"family": "de Oliveira", "given": "Tulio", "initials": "T"}, {"family": "Pond", "given": "Sergei L Kosakovsky", "initials": "SLK"}, {"family": "None", "given": "", "initials": ""}, {"family": "None", "given": "", "initials": ""}], "type": "posted-content", "published": "2021-03-05", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "6", "doi": "10.1101/2021.02.23.21252268", "pmid": null, "labels": {"Funder: H2020": null, "Category: Genomics & transcriptomics": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-06-10T03:49:19.420Z", "modified": "2021-06-18T09:11:11.931Z"}, {"entity": "publication", "iuid": "9e297cf816a3407886213128451b438e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9e297cf816a3407886213128451b438e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9e297cf816a3407886213128451b438e"}}, "title": "Point-of-care bulk testing for SARS-CoV-2 by combining hybridization capture with improved colorimetric LAMP.", "authors": [{"family": "Bokelmann", "given": "Lukas", "initials": "L"}, {"family": "Nickel", "given": "Olaf", "initials": "O"}, {"family": "Maricic", "given": "Tomislav", "initials": "T"}, {"family": "P\u00e4\u00e4bo", "given": "Svante", "initials": "S"}, {"family": "Meyer", "given": "Matthias", "initials": "M"}, {"family": "Borte", "given": "Stephan", "initials": "S"}, {"family": "Riesenberg", "given": "Stephan", "initials": "S"}], "type": "journal article", "published": "2021-03-05", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "1467", "issn-l": "2041-1723"}, "abstract": "Efforts to contain the spread of SARS-CoV-2 have spurred the need for reliable, rapid, and cost-effective diagnostic methods which can be applied to large numbers of people. However, current standard protocols for the detection of viral nucleic acids while sensitive, require a high level of automation and sophisticated laboratory equipment to achieve throughputs that allow whole communities to be tested on a regular basis. Here we present Cap-iLAMP (capture and improved loop-mediated isothermal amplification) which combines a hybridization capture-based RNA extraction of gargle lavage samples with an improved colorimetric RT-LAMP assay and smartphone-based color scoring. Cap-iLAMP is compatible with point-of-care testing and enables the detection of SARS-CoV-2 positive samples in less than one hour. In contrast to direct addition of the sample to improved LAMP (iLAMP), Cap-iLAMP prevents false positives and allows single positive samples to be detected in pools of 25 negative samples, reducing the reagent cost per test to ~1 Euro per individual.", "doi": "10.1038/s41467-021-21627-0", "pmid": "33674580", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-21627-0"}], "notes": [], "created": "2021-03-08T10:52:35.942Z", "modified": "2021-03-08T10:57:30.916Z"}, {"entity": "publication", "iuid": "78f0928173d44035925dab2beb610117", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/78f0928173d44035925dab2beb610117.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/78f0928173d44035925dab2beb610117"}}, "title": "No findings of SARS-CoV-2 in conjunctival swabs from patients at an emergency outpatient ophthalmological healthcare facility in a Swedish county hospital: a cross-sectional study.", "authors": [{"family": "Granstam", "given": "Elisabet", "initials": "E"}, {"family": "Krifors", "given": "Anders", "initials": "A"}, {"family": "Freyhult", "given": "Elisabeth", "initials": "E"}, {"family": "\u00c5kerblom", "given": "Hanna", "initials": "H"}], "type": "journal article", "published": "2021-03-05", "journal": {"title": "BMJ Open Ophthalmol", "issn": "2397-3269", "volume": "6", "issue": "1", "pages": "e000616", "issn-l": null}, "abstract": "COVID-19 is caused by SARS-CoV-2. Virus has been found in conjunctiva of hospitalised patients with COVID-19. Conjunctivitis has also been reported as a presenting symptom of disease.\n\nThe aims of the study were to investigate the prevalence of SARS-CoV-2 in the conjunctiva and throat among patients presenting at the emergency outpatient ophthalmological healthcare facility at a county hospital along with investigating the seroprevalence of SARS-CoV-2 among staff at the department.\n\nSwabs from conjunctiva and throat of patients were analysed with real-time reverse transcriptase PCR (RT-PCR) for SARS-CoV-2. Blood samples for serological analysis were obtained from staff. A questionnaire was used to investigate symptoms associated with COVID-19 during the last 3 months as well as symptoms for which the patients were seeking ophthalmological healthcare.\n\nIn total, 68 patients and 70 individuals from the staff were included in the study. Conjunctivitis was observed in 7% of patients. One patient, presenting with reduced visual acuity due to preretinal haemorrhage in the macula, was positive for SARS-CoV-2 in throat swab. Contact tracing was negative. All other RT-PCR tests were negative. Seropositivity for SARS-CoV-2 was found in 4% of staff.\n\nOur study demonstrated low prevalence of SARS-CoV-2 among patients as well as low seroprevalence of SARS-CoV-2 IgG-antibodies among staff at the ophthalmological ward. The risk for contracting COVID-19 at the department was small. Follow-up investigation is planned.", "doi": "10.1136/bmjophth-2020-000616", "pmid": "34041362", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjophth-2020-000616"}, {"db": "pmc", "key": "PMC7938470"}], "notes": [], "created": "2021-05-29T15:28:44.179Z", "modified": "2021-05-29T15:28:44.201Z"}, {"entity": "publication", "iuid": "3cee578a4158419fa545d7efe3fd8b58", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3cee578a4158419fa545d7efe3fd8b58.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3cee578a4158419fa545d7efe3fd8b58"}}, "title": "Burden of Disease Methods: A Guide to Calculate COVID-19 Disability-Adjusted Life Years.", "authors": [{"family": "Wyper", "given": "Grant M A", "initials": "GMA"}, {"family": "Assun\u00e7\u00e3o", "given": "Ricardo M A", "initials": "RMA"}, {"family": "Colzani", "given": "Edoardo", "initials": "E"}, {"family": "Grant", "given": "Ian", "initials": "I"}, {"family": "Haagsma", "given": "Juanita A", "initials": "JA"}, {"family": "Lagerweij", "given": "Giske", "initials": "G"}, {"family": "Von der Lippe", "given": "Elena", "initials": "E"}, {"family": "McDonald", "given": "Scott A", "initials": "SA"}, {"family": "Pires", "given": "Sara M", "initials": "SM"}, {"family": "Porst", "given": "Michael", "initials": "M"}, {"family": "Speybroeck", "given": "Niko", "initials": "N"}, {"family": "Devleesschauwer", "given": "Brecht", "initials": "B"}], "type": "journal article", "published": "2021-03-05", "journal": {"title": "Int J Public Health", "issn": "1661-8564", "volume": "66", "pages": "619011", "issn-l": null}, "abstract": null, "doi": "10.3389/ijph.2021.619011", "pmid": "34744580", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "619011"}, {"db": "pmc", "key": "PMC8565264"}], "notes": [], "created": "2021-11-26T15:35:22.656Z", "modified": "2021-11-26T15:35:22.669Z"}, {"entity": "publication", "iuid": "a044efb1677249b29be6bbb0a662f825", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a044efb1677249b29be6bbb0a662f825.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a044efb1677249b29be6bbb0a662f825"}}, "title": "A chronicle of SARS-CoV-2: Seasonality, environmental fate, transport, inactivation, and antiviral drug resistance.", "authors": [{"family": "Kumar", "given": "Manish", "initials": "M"}, {"family": "Mazumder", "given": "Payal", "initials": "P"}, {"family": "Mohapatra", "given": "Sanjeeb", "initials": "S"}, {"family": "Kumar Thakur", "given": "Alok", "initials": "A"}, {"family": "Dhangar", "given": "Kiran", "initials": "K"}, {"family": "Taki", "given": "Kaling", "initials": "K"}, {"family": "Mukherjee", "given": "Santanu", "initials": "S"}, {"family": "Kumar Patel", "given": "Arbind", "initials": "A"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Mohapatra", "given": "Pranab", "initials": "P"}, {"family": "Rinklebe", "given": "J\u00f6rg", "initials": "J"}, {"family": "Kitajima", "given": "Masaaki", "initials": "M"}, {"family": "Hai", "given": "Faisal I", "initials": "FI"}, {"family": "Khursheed", "given": "Anwar", "initials": "A"}, {"family": "Furumai", "given": "Hiroaki", "initials": "H"}, {"family": "Sonne", "given": "Christian", "initials": "C"}, {"family": "Kuroda", "given": "Keisuke", "initials": "K"}], "type": "journal article", "published": "2021-03-05", "journal": {"title": "J Hazard Mater", "issn": "1873-3336", "volume": "405", "issue": null, "pages": "124043", "issn-l": null}, "abstract": "In this review, we present the environmental perspectives of the viruses and antiviral drugs related to SARS-CoV-2. The present review paper discusses occurrence, fate, transport, susceptibility, and inactivation mechanisms of viruses in the environment as well as environmental occurrence and fate of antiviral drugs, and prospects (prevalence and occurrence) of antiviral drug resistance (both antiviral drug resistant viruses and antiviral resistance in the human). During winter, the number of viral disease cases and environmental occurrence of antiviral drug surge due to various biotic and abiotic factors such as transmission pathways, human behaviour, susceptibility, and immunity as well as cold climatic conditions. Adsorption and persistence critically determine the fate and transport of viruses in the environment. Inactivation and disinfection of virus include UV, alcohol, and other chemical-base methods but the susceptibility of virus against these methods varies. Wastewater treatment plants (WWTPs) are major reserviors of antiviral drugs and their metabolites and transformation products. Ecotoxicity of antiviral drug residues against aquatic organisms have been reported, however more threatening is the development of antiviral resistance, both in humans and in wild animal reservoirs. In particular, emergence of antiviral drug-resistant viruses via exposure of wild animals to high loads of antiviral residues during the current pandemic needs further evaluation.", "doi": "10.1016/j.jhazmat.2020.124043", "pmid": "33268203", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0304-3894(20)32033-1"}, {"db": "pmc", "key": "PMC7536132"}], "notes": [], "created": "2021-02-10T18:52:29.712Z", "modified": "2021-02-10T18:53:14.080Z"}, {"entity": "publication", "iuid": "2df5739354b6453abf381a53d3a6c530", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2df5739354b6453abf381a53d3a6c530.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2df5739354b6453abf381a53d3a6c530"}}, "title": "OmicLoupe: facilitating biological discovery by interactive exploration of multiple omic datasets and statistical comparisons.", "authors": [{"family": "Willforss", "given": "Jakob", "initials": "J"}, {"family": "Siino", "given": "Valentina", "initials": "V"}, {"family": "Levander", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2021-03-04", "journal": {"title": "BMC Bioinformatics", "issn": "1471-2105", "volume": "22", "issue": "1", "pages": "107", "issn-l": null}, "abstract": "Visual exploration of gene product behavior across multiple omic datasets can pinpoint technical limitations in data and reveal biological trends. Still, such exploration is challenging as there is a need for visualizations that are tailored for the purpose.\n\nThe OmicLoupe software was developed to facilitate visual data exploration and provides more than 15 interactive cross-dataset visualizations for omics data. It expands visualizations to multiple datasets for quality control, statistical comparisons and overlap and correlation analyses, while allowing for rapid inspection and downloading of selected features. The usage of OmicLoupe is demonstrated in three different studies, where it allowed for detection of both technical data limitations and biological trends across different omic layers. An example is an analysis of SARS-CoV-2 infection based on two previously published studies, where OmicLoupe facilitated the identification of gene products with consistent expression changes across datasets at both the transcript and protein levels.\n\nOmicLoupe provides fast exploration of omics data with tailored visualizations for comparisons within and across data layers. The interactive visualizations are highly informative and are expected to be useful in various analyses of both newly generated and previously published data. OmicLoupe is available at quantitativeproteomics.org/omicloupe.", "doi": "10.1186/s12859-021-04043-5", "pmid": "33663372", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12859-021-04043-5"}], "notes": [], "created": "2021-03-06T10:15:06.148Z", "modified": "2021-03-06T10:15:06.170Z"}, {"entity": "publication", "iuid": "e52c4079071d410b99cb020629c9705c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e52c4079071d410b99cb020629c9705c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e52c4079071d410b99cb020629c9705c"}}, "title": "Antibodies to SARS-CoV-2 and risk of past or future sick leave.", "authors": [{"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Elfstr\u00f6m", "given": "K Miriam", "initials": "KM"}, {"family": "Blomqvist", "given": "Jonas", "initials": "J"}, {"family": "Eklund", "given": "Carina", "initials": "C"}, {"family": "Lagheden", "given": "Camilla", "initials": "C"}, {"family": "Nordqvist-Kleppe", "given": "Sara", "initials": "S"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Olofsson", "given": "Jennie", "initials": "J"}, {"family": "Andersson", "given": "Eni", "initials": "E"}, {"family": "Jernbom Falk", "given": "August", "initials": "A"}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S"}, {"family": "Hultin", "given": "Emilie", "initials": "E"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Mattsson", "given": "Johan", "initials": "J"}, {"family": "M\u00fchr", "given": "Laila Sara Arroyo", "initials": "LSA"}, {"family": "Conneryd Lundgren", "given": "Kalle", "initials": "K"}], "type": "journal article", "published": "2021-03-04", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "5160"}, "abstract": "The extent that antibodies to SARS-CoV-2 may protect against future virus-associated disease is unknown. We invited all employees (n = 15,300) at work at the Karolinska University Hospital, Stockholm, Sweden to participate in a study examining SARS-Cov-2 antibodies in relation to registered sick leave. For consenting 12,928 healthy hospital employees antibodies to SARS-CoV-2 could be determined and compared to participant sick leave records. Subjects with viral serum antibodies were not at excess risk for future sick leave (adjusted odds ratio (OR) controlling for age and sex: 0.85 [95% confidence interval (CI) (0.85 (0.43-1.68)]. By contrast, subjects with antibodies had an excess risk for sick leave in the weeks prior to testing [adjusted OR in multivariate analysis: 3.34 (2.98-3.74)]. Thus, presence of viral antibodies marks past disease and protection against excess risk of future disease. Knowledge of whether exposed subjects have had disease in the past or are at risk for future disease is essential for planning of control measures.Trial registration: First registered on 02/06/20, ClinicalTrials.gov NCT04411576.", "doi": "10.1038/s41598-021-84356-w", "pmid": "33664279", "labels": {"Category: Health": null, "Category: Proteins": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Research Area: High-throughput and high-content serology": null}, "xrefs": [{"db": "pmc", "key": "PMC7933367"}, {"db": "pii", "key": "10.1038/s41598-021-84356-w"}, {"db": "ClinicalTrials.gov", "key": "NCT04411576"}], "notes": [], "created": "2021-03-06T10:13:45.982Z", "modified": "2023-06-19T14:23:55.553Z"}, {"entity": "publication", "iuid": "66c7514e2642441da18b49f672fd2839", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66c7514e2642441da18b49f672fd2839.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66c7514e2642441da18b49f672fd2839"}}, "title": "Seroprevalence of coronavirus disease 2019 (COVID-19) among health care workers from three pandemic hospitals of Turkey.", "authors": [{"family": "Alkurt", "given": "Gizem", "initials": "G"}, {"family": "Murt", "given": "Ahmet", "initials": "A"}, {"family": "Aydin", "given": "Zeki", "initials": "Z"}, {"family": "Tatli", "given": "Ozge", "initials": "O"}, {"family": "Agaoglu", "given": "Nihat Bugra", "initials": "NB"}, {"family": "Irvem", "given": "Arzu", "initials": "A"}, {"family": "Aydin", "given": "Mehtap", "initials": "M"}, {"family": "Karaali", "given": "Ridvan", "initials": "R"}, {"family": "Gunes", "given": "Mustafa", "initials": "M"}, {"family": "Yesilyurt", "given": "Batuhan", "initials": "B"}, {"family": "Turkez", "given": "Hasan", "initials": "H"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A"}, {"family": "Doganay", "given": "Mehmet", "initials": "M"}, {"family": "Basinoglu", "given": "Filiz", "initials": "F"}, {"family": "Seyahi", "given": "Nurhan", "initials": "N"}, {"family": "Dinler Doganay", "given": "Gizem", "initials": "G"}, {"family": "Doganay", "given": "Hamdi Levent", "initials": "HL"}], "type": "journal article", "published": "2021-03-03", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "3", "pages": "e0247865", "issn-l": "1932-6203"}, "abstract": "COVID-19 is a global threat with an increasing number of infections. Research on IgG seroprevalence among health care workers (HCWs) is needed to re-evaluate health policies. This study was performed in three pandemic hospitals in Istanbul and Kocaeli. Different clusters of HCWs were screened for SARS-CoV-2 infection. Seropositivity rate among participants was evaluated by chemiluminescent microparticle immunoassay. We recruited 813 non-infected and 119 PCR-confirmed infected HCWs. Of the previously undiagnosed HCWs, 22 (2.7%) were seropositive. Seropositivity rates were highest for cleaning staff (6%), physicians (4%), nurses (2.2%) and radiology technicians (1%). Non-pandemic clinic (6.4%) and ICU (4.3%) had the highest prevalence. HCWs in \"high risk\" group had similar seropositivity rate with \"no risk\" group (2.9 vs 3.5 p = 0.7). These findings might lead to the re-evaluation of infection control and transmission dynamics in hospitals.", "doi": "10.1371/journal.pone.0247865", "pmid": "33657142", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-35740"}], "notes": [], "created": "2021-03-04T14:59:29.060Z", "modified": "2021-03-04T14:59:44.375Z"}, {"entity": "publication", "iuid": "bd36b3d1e82d4558a7b9f1fdd6cd21c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bd36b3d1e82d4558a7b9f1fdd6cd21c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bd36b3d1e82d4558a7b9f1fdd6cd21c0"}}, "title": "In education we trust: on handling the COVID-19 Pandemic in the Swedish welfare state.", "authors": [{"family": "Lindblad", "given": "Sverker", "initials": "S", "orcid": "0000-0003-3481-3686", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/643e57912c7b487abde1d0bb0cb62bcd.json"}}, {"family": "Lindqvist", "given": "Anders", "initials": "A"}, {"family": "Runesdotter", "given": "Caroline", "initials": "C"}, {"family": "W\u00e4rvik", "given": "Gun-Britt", "initials": "GB"}], "type": "journal article", "published": "2021-03-03", "journal": {"title": "Z Erziehungswiss", "issn": "1434-663X", "volume": "24", "issue": "2", "pages": "503-519", "issn-l": null}, "abstract": "Keeping schools open was an active strategy in Sweden to meet the threats of the COVID-19 pandemic. In this article we analyze how a collection of welfare state agents with different tasks, resources and interests in interaction formed an assemblage in their responses to the pandemic and how education thereby became part of a strategy to keep the society going. The inquiries concern what this tells us about education as framed and constrained as a part of society. Our observations are based on statements presented by the government and public agencies, mass media and websites. We identified an assemblage of interwoven agents such as institutions, laws, regulations and recommendations, pandemic manuals, statistics and media. All these were brought together by actions and ideas to handle a pandemic when there were no preventive vaccines. The overarching principle was to educate the population to competent actions in dealing with the pandemic. To keep schools open was part of that principle combined with caretaking ambitions. This assemblage looked like a centralistic machine but it was not; risks were pushed back to local authorities and schools. In conclusion, we note that education is vital in the overarching strategy to deal with the pandemic in Sweden in terms of trust in people and governmentality.", "doi": "10.1007/s11618-021-01001-y", "pmid": "33686342", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7927774"}, {"db": "pii", "key": "1001"}], "notes": [], "created": "2021-03-09T15:38:30.715Z", "modified": "2023-06-19T15:03:30.315Z"}, {"entity": "publication", "iuid": "a0855feda5bb4681ad704142bd8b900e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a0855feda5bb4681ad704142bd8b900e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a0855feda5bb4681ad704142bd8b900e"}}, "title": "Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity.", "authors": [{"family": "Hoffmann", "given": "Markus", "initials": "M"}, {"family": "Hofmann-Winkler", "given": "Heike", "initials": "H"}, {"family": "Smith", "given": "Joan C", "initials": "JC"}, {"family": "Kr\u00fcger", "given": "Nadine", "initials": "N"}, {"family": "Arora", "given": "Prerna", "initials": "P"}, {"family": "S\u00f8rensen", "given": "Lambert K", "initials": "LK"}, {"family": "S\u00f8gaard", "given": "Ole S", "initials": "OS"}, {"family": "Hasselstr\u00f8m", "given": "J\u00f8rgen Bo", "initials": "JB"}, {"family": "Winkler", "given": "Michael", "initials": "M"}, {"family": "Hempel", "given": "Tim", "initials": "T"}, {"family": "Raich", "given": "Llu\u00eds", "initials": "L"}, {"family": "Olsson", "given": "Simon", "initials": "S"}, {"family": "Danov", "given": "Olga", "initials": "O"}, {"family": "Jonigk", "given": "Danny", "initials": "D"}, {"family": "Yamazoe", "given": "Takashi", "initials": "T"}, {"family": "Yamatsuta", "given": "Katsura", "initials": "K"}, {"family": "Mizuno", "given": "Hirotaka", "initials": "H"}, {"family": "Ludwig", "given": "Stephan", "initials": "S"}, {"family": "No\u00e9", "given": "Frank", "initials": "F"}, {"family": "Kjolby", "given": "Mads", "initials": "M"}, {"family": "Braun", "given": "Armin", "initials": "A"}, {"family": "Sheltzer", "given": "Jason M", "initials": "JM"}, {"family": "P\u00f6hlmann", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2021-03-03", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "volume": null, "issue": null, "pages": "103255", "issn-l": null}, "abstract": "Antivirals are needed to combat the COVID-19 pandemic, which is caused by SARS-CoV-2. The clinically-proven protease inhibitor Camostat mesylate inhibits SARS-CoV-2 infection by blocking the virus-activating host cell protease TMPRSS2. However, antiviral activity of Camostat mesylate metabolites and potential viral resistance have not been analyzed. Moreover, antiviral activity of Camostat mesylate in human lung tissue remains to be demonstrated.\n\nWe used recombinant TMPRSS2, reporter particles bearing the spike protein of SARS-CoV-2 or authentic SARS-CoV-2 to assess inhibition of TMPRSS2 and viral entry, respectively, by Camostat mesylate and its metabolite GBPA.\n\nWe show that several TMPRSS2-related proteases activate SARS-CoV-2 and that two, TMPRSS11D and TMPRSS13, are robustly expressed in the upper respiratory tract. However, entry mediated by these proteases was blocked by Camostat mesylate. The Camostat metabolite GBPA inhibited recombinant TMPRSS2 with reduced efficiency as compared to Camostat mesylate. In contrast, both inhibitors exhibited similar antiviral activity and this correlated with the rapid conversion of Camostat mesylate into GBPA in the presence of serum. Finally, Camostat mesylate and GBPA blocked SARS-CoV-2 spread in human lung tissue ex vivo and the related protease inhibitor Nafamostat mesylate exerted augmented antiviral activity.\n\nOur results suggest that SARS-CoV-2 can use TMPRSS2 and closely related proteases for spread in the upper respiratory tract and that spread in the human lung can be blocked by Camostat mesylate and its metabolite GBPA.\n\nNIH, Damon Runyon Foundation, ACS, NYCT, DFG, EU, Berlin Mathematics center MATH+, BMBF, Lower Saxony, Lundbeck Foundation, Novo Nordisk Foundation.", "doi": "10.1016/j.ebiom.2021.103255", "pmid": "33676899", "labels": {"Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2352-3964(21)00048-7"}], "notes": [], "created": "2021-03-09T06:29:35.329Z", "modified": "2021-03-09T06:29:35.339Z"}, {"entity": "publication", "iuid": "ccc828de9ffc4d4faf4cbfa6038f8205", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ccc828de9ffc4d4faf4cbfa6038f8205.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ccc828de9ffc4d4faf4cbfa6038f8205"}}, "title": "The effects of school closures on SARS-CoV-2 among parents and teachers.", "authors": [{"family": "Vlachos", "given": "Jonas", "initials": "J"}, {"family": "Herteg\u00e5rd", "given": "Edvin", "initials": "E"}, {"family": "B Svaleryd", "given": "Helena", "initials": "H"}], "type": "journal article", "published": "2021-03-02", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "issn-l": "0027-8424", "volume": "118", "issue": "9", "pages": null}, "abstract": "To reduce the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), most countries closed schools, despite uncertainty if school closures are an effective containment measure. At the onset of the pandemic, Swedish upper-secondary schools moved to online instruction, while lower-secondary schools remained open. This allows for a comparison of parents and teachers differently exposed to open and closed schools, but otherwise facing similar conditions. Leveraging rich Swedish register data, we connect all students and teachers in Sweden to their families and study the impact of moving to online instruction on the incidence of SARS-CoV-2 and COVID-19. We find that, among parents, exposure to open rather than closed schools resulted in a small increase in PCR-confirmed infections (odds ratio [OR] 1.17; 95% CI [CI95] 1.03 to 1.32). Among lower-secondary teachers, the infection rate doubled relative to upper-secondary teachers (OR 2.01; CI95 1.52 to 2.67). This spilled over to the partners of lower-secondary teachers, who had a higher infection rate than their upper-secondary counterparts (OR 1.29; CI95 1.00 to 1.67). When analyzing COVID-19 diagnoses from healthcare visits and the incidence of severe health outcomes, results are similar for teachers, but weaker for parents and teachers' partners. The results for parents indicate that keeping lower-secondary schools open had minor consequences for the overall transmission of SARS-CoV-2 in society. The results for teachers suggest that measures to protect teachers could be considered.", "doi": "10.1073/pnas.2020834118", "pmid": "33574041", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "2020834118"}, {"db": "URL", "key": "https://doi.org/10.17605/OSF.IO/4ZEGU", "description": "Analysis code"}, {"db": "NA", "key": "Data available from Statistics Sweden, the Public Health Agency, the National Board of Health and Welfare", "description": null}], "notes": [], "created": "2021-02-15T10:48:23.120Z", "modified": "2022-11-23T09:02:06.517Z"}, {"entity": "publication", "iuid": "6fc0a21da50a4bddbdf07a5a63b48e36", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6fc0a21da50a4bddbdf07a5a63b48e36.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6fc0a21da50a4bddbdf07a5a63b48e36"}}, "title": "Protection induced by a human monoclonal antibody recognizing two different epitopes in a conserved region of streptococcal M proteins", "authors": [{"family": "Bahnan", "given": "Wael", "initials": "W"}, {"family": "Happonen", "given": "Lotta", "initials": "L"}, {"family": "Khakzad", "given": "Hamed", "initials": "H"}, {"family": "Ahnlide", "given": "Vibha Kumra", "initials": "VK"}, {"family": "de Neergaard", "given": "Therese", "initials": "T"}, {"family": "Wrighton", "given": "Sebastian", "initials": "S"}, {"family": "Bratanis", "given": "Eleni", "initials": "E"}, {"family": "Tang", "given": "Di", "initials": "D"}, {"family": "Hellmark", "given": "Thomas", "initials": "T"}, {"family": "Bj\u00f6rck", "given": "Lars", "initials": "L"}, {"family": "Shannon", "given": "Oonagh", "initials": "O"}, {"family": "Malmstr\u00f6m", "given": "Lars", "initials": "L"}, {"family": "Malmstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Nordenfelt", "given": "Pontus", "initials": "P"}], "type": "posted-content", "published": "2021-03-02", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.01.433494", "pmid": null, "labels": {"Category: Biochemistry": null, "Category: Proteins": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-03-22T12:39:21.164Z", "modified": "2021-03-22T13:33:56.820Z"}, {"entity": "publication", "iuid": "cec1e1228ccc42ad9bca389bad602a9e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cec1e1228ccc42ad9bca389bad602a9e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cec1e1228ccc42ad9bca389bad602a9e"}}, "title": "Has COVID-19 Improved Public Awareness on Oral Hygiene?", "authors": [{"family": "SOROOSHIAN", "given": "Shahryar", "initials": "S"}, {"family": "KUMAR", "given": "Senthil", "initials": "S"}], "type": "journal-article", "published": "2021-03-02", "journal": {"title": "ijph", "issn": "2251-6093", "issn-l": null}, "abstract": null, "doi": "10.18502/ijph.v50i3.5626", "pmid": null, "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:06:14.132Z", "modified": "2021-06-28T18:06:14.163Z"}, {"entity": "publication", "iuid": "564a9c99c97f4c13914ec11dd3809290", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/564a9c99c97f4c13914ec11dd3809290.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/564a9c99c97f4c13914ec11dd3809290"}}, "title": "Epidemiology and transmission characteristics of early COVID-19 cases, 20 January-19 March 2020, in Bavaria, Germany.", "authors": [{"family": "B\u00f6hm", "given": "S", "initials": "S", "orcid": "0000-0002-5807-8092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4eb44d818744a98bc5e936918ffd690.json"}}, {"family": "Woudenberg", "given": "T", "initials": "T"}, {"family": "Chen", "given": "D", "initials": "D"}, {"family": "Marosevic", "given": "D V", "initials": "DV"}, {"family": "B\u00f6hmer", "given": "M M", "initials": "MM"}, {"family": "Hansen", "given": "L", "initials": "L"}, {"family": "Wallinga", "given": "J", "initials": "J"}, {"family": "Sing", "given": "A", "initials": "A"}, {"family": "Katz", "given": "K", "initials": "K"}], "type": "journal article", "published": "2021-03-02", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": "149", "issue": null, "pages": "e65", "issn-l": null}, "abstract": "Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) led to a significant disease burden and disruptions in health systems. We describe the epidemiology and transmission characteristics of early coronavirus disease 2019 (COVID-19) cases in Bavaria, Germany. Cases were reverse transcription polymerase chain reaction (RT-PCR)-confirmed SARS-CoV-2 infections, reported from 20 January-19 March 2020. The incubation period was estimated using travel history and date of symptom onset. To estimate the serial interval, we identified pairs of index and secondary cases. By 19 March, 3546 cases were reported. A large proportion was exposed abroad (38%), causing further local transmission. Median incubation period of 256 cases with exposure abroad was 3.8 days (95%CI: 3.5-4.2). For 95% of infected individuals, symptom onset occurred within 10.3 days (95%CI: 9.1-11.8) after exposure. The median serial interval, using 53 pairs, was 3.5 days (95%CI: 3.0-4.2; mean: 3.9, s.d.: 2.2). Travellers returning to Germany had an important influence on the spread of SARS-CoV-2 infections in Bavaria in early 2020. Especially in times of low incidence, public health agencies should identify holiday destinations, and areas with ongoing local transmission, to monitor potential importation of SARS-CoV-2 infections. Travellers returning from areas with ongoing community transmission should be advised to quarantine to prevent re-introductions of COVID-19.", "doi": "10.1017/S0950268821000510", "pmid": "33650470", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7985897"}, {"db": "pii", "key": "S0950268821000510"}], "notes": [], "created": "2021-03-03T17:00:47.834Z", "modified": "2023-06-19T15:24:04.172Z"}, {"entity": "publication", "iuid": "ffff55339bad42d49fd284235c6370e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ffff55339bad42d49fd284235c6370e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ffff55339bad42d49fd284235c6370e8"}}, "title": "A genomic region associated with protection against severe COVID-19 is inherited from Neandertals", "authors": [{"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "P\u00e4\u00e4bo", "given": "Svante", "initials": "S"}], "type": "journal-article", "published": "2021-03-02", "journal": {"title": "Proc Natl Acad Sci USA", "issn": "0027-8424", "issn-l": "0027-8424", "volume": "118", "issue": "9", "pages": "e2026309118"}, "abstract": null, "doi": "10.1073/pnas.2026309118", "pmid": null, "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [], "notes": [], "created": "2021-02-17T15:07:25.648Z", "modified": "2021-02-26T08:45:14.519Z"}, {"entity": "publication", "iuid": "35bd0616989944c68f1bb94cceed8411", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/35bd0616989944c68f1bb94cceed8411.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/35bd0616989944c68f1bb94cceed8411"}}, "title": "Time series analysis and mechanistic modelling of heterogeneity and sero-reversion in antibody responses to mild SARS\u2011CoV-2 infection.", "authors": [{"family": "Manisty", "given": "Charlotte", "initials": "C"}, {"family": "Treibel", "given": "Thomas Alexander", "initials": "TA"}, {"family": "Jensen", "given": "Melanie", "initials": "M"}, {"family": "Semper", "given": "Amanda", "initials": "A"}, {"family": "Joy", "given": "George", "initials": "G"}, {"family": "Gupta", "given": "Rishi K", "initials": "RK"}, {"family": "Cutino-Moguel", "given": "Teresa", "initials": "T"}, {"family": "Andiapen", "given": "Mervyn", "initials": "M"}, {"family": "Jones", "given": "Jessica", "initials": "J"}, {"family": "Taylor", "given": "Stephen", "initials": "S"}, {"family": "Otter", "given": "Ashley", "initials": "A"}, {"family": "Pade", "given": "Corrina", "initials": "C"}, {"family": "Gibbons", "given": "Joseph", "initials": "J"}, {"family": "Lee", "given": "Jason", "initials": "J"}, {"family": "Bacon", "given": "Joanna", "initials": "J"}, {"family": "Thomas", "given": "Steve", "initials": "S"}, {"family": "Moon", "given": "Chris", "initials": "C"}, {"family": "Jones", "given": "Meleri", "initials": "M"}, {"family": "Williams", "given": "Dylan", "initials": "D"}, {"family": "Lambourne", "given": "Jonathan", "initials": "J"}, {"family": "Fontana", "given": "Marianna", "initials": "M"}, {"family": "Altmann", "given": "Daniel M", "initials": "DM"}, {"family": "Boyton", "given": "Rosemary", "initials": "R"}, {"family": "Maini", "given": "Mala", "initials": "M"}, {"family": "McKnight", "given": "Aine", "initials": "A"}, {"family": "Chain", "given": "Benjamin", "initials": "B"}, {"family": "Noursadeghi", "given": "Mahdad", "initials": "M"}, {"family": "Moon", "given": "James C", "initials": "JC"}], "type": "journal article", "published": "2021-03-01", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": "65", "issue": null, "pages": "103259"}, "abstract": "SARS-CoV-2 serology is used to identify prior infection at individual and at population level. Extended longitudinal studies with multi-timepoint sampling to evaluate dynamic changes in antibody levels are required to identify the time horizon in which these applications of serology are valid, and to explore the longevity of protective humoral immunity.\r\n\r\nHealthcare workers were recruited to a prospective cohort study from the first SARS-CoV-2 epidemic peak in London, undergoing weekly symptom screen, viral PCR and blood sampling over 16-21 weeks. Serological analysis (n =12,990) was performed using semi-quantitative Euroimmun IgG to viral spike S1 domain and Roche total antibody to viral nucleocapsid protein (NP) assays. Comparisons were made to pseudovirus neutralizing antibody measurements.\r\n\r\nA total of 157/729 (21.5%) participants developed positive SARS-CoV-2 serology by one or other assay, of whom 31.0% were asymptomatic and there were no deaths. Peak Euroimmun anti-S1 and Roche anti-NP measurements correlated (r = 0.57, p<0.0001) but only anti-S1 measurements correlated with near-contemporary pseudovirus neutralising antibody titres (measured at 16-18 weeks, r = 0.57, p<0.0001). By 21 weeks' follow-up, 31/143 (21.7%) anti-S1 and 6/150 (4.0%) anti-NP measurements reverted to negative. Mathematical modelling revealed faster clearance of anti-S1 compared to anti-NP (median half-life of 2.5 weeks versus 4.0 weeks), earlier transition to lower levels of antibody production (median of 8 versus 13 weeks), and greater reductions in relative antibody production rate after the transition (median of 35% versus 50%).\r\n\r\nMild SARS-CoV-2 infection is associated with heterogeneous serological responses in Euroimmun anti-S1 and Roche anti-NP assays. Anti-S1 responses showed faster rates of clearance, more rapid transition from high to low level production rate and greater reduction in production rate after this transition. In mild infection, anti-S1 serology alone may underestimate incident infections. The mechanisms that underpin faster clearance and lower rates of sustained anti-S1 production may impact on the longevity of humoral immunity.\r\n\r\nCharitable donations via Barts Charity, Wellcome Trust, NIHR.", "doi": "10.1016/j.ebiom.2021.103259", "pmid": "33662833", "labels": {"Category: Proteins": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "S2352-3964(21)00052-9"}, {"db": "pmc", "key": "PMC7920816"}, {"db": "URL", "key": "https://covid-consortium.com/", "description": "Applications for access to the individual participant de-identified data (including data dictionaries) and samples can be made to the access committee"}], "notes": [], "created": "2021-03-06T10:15:49.479Z", "modified": "2021-03-12T10:31:44.422Z"}, {"entity": "publication", "iuid": "a956b3bcb88f402da5231b8f655fa49e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a956b3bcb88f402da5231b8f655fa49e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a956b3bcb88f402da5231b8f655fa49e"}}, "title": "Why people failed to adhere to COVID-19 preventive behaviors? Perspectives from an integrated behavior change model", "authors": [{"family": "Chan", "given": "Derwin K C", "initials": "DKC", "orcid": "0000-0001-8200-0263", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37f65888980c44a4a60077bfb9c2a943.json"}}, {"family": "Zhang", "given": "Chun Qing", "initials": "CQ"}, {"family": "Weman-Josefsson", "given": "Karin", "initials": "K"}], "type": "journal-article", "published": "2021-03-00", "journal": {"title": "Infect Control Hosp Epidemiol", "issn": "0899-823X", "volume": "42", "issue": "3", "pages": "375-376", "issn-l": null}, "abstract": null, "doi": "10.1017/ice.2020.245", "pmid": "32408917", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0899823X20002457"}, {"db": "pmc", "key": "PMC7253766"}], "notes": [], "created": "2020-12-10T08:49:50.394Z", "modified": "2021-12-06T13:14:00.408Z"}, {"entity": "publication", "iuid": "d3240cf5394c47d98e0b3177006fc717", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3240cf5394c47d98e0b3177006fc717.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3240cf5394c47d98e0b3177006fc717"}}, "title": "What do people hospitalised with COVID-19 think about their care? Results of a satisfaction survey during the first wave of COVID-19 in Liverpool.", "authors": [{"family": "Wu", "given": "Meng-San", "initials": "MS"}, {"family": "Watson", "given": "Rebecca", "initials": "R"}, {"family": "Hayat", "given": "Fatima", "initials": "F"}, {"family": "Ratcliffe", "given": "Libuse", "initials": "L"}, {"family": "Beadsworth", "given": "Mike Bj", "initials": "MB"}, {"family": "McKenna", "given": "Mark", "initials": "M"}, {"family": "Corney", "given": "Daniel", "initials": "D"}, {"family": "Plum", "given": "Catherine", "initials": "C"}, {"family": "Macfarlane", "given": "Jamie-Leigh", "initials": "JL"}, {"family": "Matareed", "given": "Maisoon", "initials": "M"}, {"family": "Butt", "given": "Sundas", "initials": "S"}, {"family": "Gupta", "given": "Sandipika", "initials": "S"}, {"family": "Hine", "given": "Paul", "initials": "P"}, {"family": "Defres", "given": "Sylviane", "initials": "S"}, {"family": "Wingfield", "given": "Tom", "initials": "T"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Future Healthc J", "issn": "2514-6645", "volume": "8", "issue": "1", "pages": "e70-e75", "issn-l": null}, "abstract": "Despite huge advances in vaccines, testing and treatments for COVID-19, there is negligible evidence on the perceptions of people hospitalised with COVID-19 about the care they received. To address this, we developed a satisfaction survey for people with COVID-19 admitted to our hospital during the first COVID-19 wave in Liverpool. Of those invited, 98/160 (61%) responded, of whom 94/98 (96%) completed the survey. Respondents rated overall care highly (mean 4.7/5) and 89/94 (95%) reported that they would recommend the hospital to friends and/or family. Most respondents felt safe on the ward (94%), with privacy maintained (93%) and pain well managed (90%). Fewer than two-thirds (63%) of respondents considered themselves adequately consulted regarding medications and side effects. Sleep and food/drink quality were also highlighted as areas for improvement. To overcome the issues raised, we generated a 'COVID-19 practice pointers' poster within an integrated educational bundle on COVID-19 wards. The impact of the bundle on perceptions of people hospitalised with COVID-19 will be evaluated in people hospitalised with COVID-19 in Liverpool in 2021. Whether hospitalised for COVID-19 or other conditions, our survey results are a timely reminder of the importance of involving patients in shaping the care that they receive.", "doi": "10.7861/fhj.2020-0260", "pmid": "33791480", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "futurehealth"}, {"db": "pmc", "key": "PMC8004304"}], "notes": [], "created": "2021-04-06T10:43:07.126Z", "modified": "2021-04-06T10:43:07.149Z"}, {"entity": "publication", "iuid": "7571e2cc6b564849b2e75ed1c8c76404", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7571e2cc6b564849b2e75ed1c8c76404.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7571e2cc6b564849b2e75ed1c8c76404"}}, "title": "Very little influenza in the WHO European Region during the 2020/21 season, weeks 40 2020 to 8 2021.", "authors": [{"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Mook", "given": "Piers", "initials": "P"}, {"family": "Lamb", "given": "Favelle", "initials": "F"}, {"family": "Ferland", "given": "Lisa", "initials": "L"}, {"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "Amato-Gauci", "given": "Andrew J", "initials": "AJ"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "European Influenza Surveillance Network", "given": "", "initials": ""}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "11", "pages": null}, "abstract": "Between weeks 40 2020 and 8 2021, the World Health Organization European Region experienced a 99.8% reduction in sentinel influenza virus positive detections (33/25,606 tested; 0.1%) relative to an average of 14,966/39,407 (38.0%; p < 0.001) over the same time in the previous six seasons. COVID-19 pandemic public health and physical distancing measures may have extinguished the 2020/21 European seasonal influenza epidemic with just a few sporadic detections of all viral subtypes. This might possibly continue during the remainder of the influenza season.", "doi": "10.2807/1560-7917.ES.2021.26.11.2100221", "pmid": "33739256", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-22T10:31:59.380Z", "modified": "2021-06-18T14:39:21.838Z"}, {"entity": "publication", "iuid": "05093540bf5441dfb79be809471bc698", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/05093540bf5441dfb79be809471bc698.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/05093540bf5441dfb79be809471bc698"}}, "title": "Towards a sensitive and accurate interpretation of molecular testing for SARS-CoV-2: a rapid review of 264 studies.", "authors": [{"family": "Stanoeva", "given": "Kamelia R", "initials": "KR"}, {"family": "van der Eijk", "given": "Annemiek A", "initials": "AA"}, {"family": "Meijer", "given": "Adam", "initials": "A"}, {"family": "Kortbeek", "given": "Laetitia M", "initials": "LM"}, {"family": "Koopmans", "given": "Marion P G", "initials": "MPG"}, {"family": "Reusken", "given": "Chantal B E M", "initials": "CBEM"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "10", "issn-l": null}, "abstract": "BackgroundSensitive molecular diagnostics and correct test interpretation are crucial for accurate COVID-19 diagnosis and thereby essential for good clinical practice. Furthermore, they are a key factor in outbreak control where active case finding in combination with isolation and contact tracing are crucial.AimWith the objective to inform the public health and laboratory responses to the pandemic, we reviewed current published knowledge on the kinetics of SARS-CoV-2 infection as assessed by RNA molecular detection in a wide range of clinical samples.MethodsWe performed an extensive search on studies published between 1 December 2019 and 15 May 2020, reporting on molecular detection and/or isolation of SARS-CoV-2 in any human laboratory specimen.ResultsWe compiled a dataset of 264 studies including 32,515 COVID-19 cases, and additionally aggregated data points (n = 2,777) from sampling of 217 adults with known infection timeline. We summarised data on SARS-CoV-2 detection in the respiratory and gastrointestinal tract, blood, oral fluid, tears, cerebrospinal fluid, peritoneal fluid, semen, vaginal fluid; where provided, we also summarised specific observations on SARS-CoV-2 detection in pregnancy, infancy, children, adolescents and immunocompromised individuals.ConclusionOptimal SARS-CoV-2 molecular testing relies on choosing the most appropriate sample type, collected with adequate sampling technique, and with the infection timeline in mind. We outlined knowledge gaps and directions for future well-documented systematic studies.", "doi": "10.2807/1560-7917.ES.2021.26.10.2001134", "pmid": "33706863", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-03-17T07:09:27.560Z", "modified": "2021-03-17T07:09:27.570Z"}, {"entity": "publication", "iuid": "cb6807f591e447ac8b78e9df7a413cd3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cb6807f591e447ac8b78e9df7a413cd3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cb6807f591e447ac8b78e9df7a413cd3"}}, "title": "The new normal of social psychology in the face of the COVID-19 pandemic: Insights and advice from leaders in the field.", "authors": [{"family": "Tam", "given": "Kim-Pong", "initials": "KP"}, {"family": "Leung", "given": "Angela K-Y", "initials": "AK"}, {"family": "Khan", "given": "Sammyh", "initials": "S"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Asian J Soc Psychol", "issn": "1367-2223", "volume": "24", "issue": "1", "pages": "8-9", "issn-l": null}, "abstract": null, "doi": "10.1111/ajsp.12468", "pmid": "33821135", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "AJSP12468"}, {"db": "pmc", "key": "PMC8014449"}], "notes": [], "created": "2021-04-07T10:10:20.671Z", "modified": "2021-04-07T10:10:48.343Z"}, {"entity": "publication", "iuid": "6887e04239de45d69ce855e4c8d0b90f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6887e04239de45d69ce855e4c8d0b90f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6887e04239de45d69ce855e4c8d0b90f"}}, "title": "The Psychological Functioning in the COVID-19 Pandemic and Its Association with Psychological Flexibility and Broader Functioning in People with Chronic Pain", "authors": [{"family": "Yu", "given": "Lin", "initials": "L"}, {"family": "Kioskli", "given": "Kitty", "initials": "K"}, {"family": "McCracken", "given": "Lance M", "initials": "LM"}], "type": "journal-article", "published": "2021-03-00", "journal": {"title": "The Journal of Pain", "issn": "1526-5900", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.jpain.2021.02.011", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-03-09T06:28:16.006Z", "modified": "2021-03-09T06:28:32.481Z"}, {"entity": "publication", "iuid": "5a5780c724224d5eb0b814962d3ac220", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5a5780c724224d5eb0b814962d3ac220.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5a5780c724224d5eb0b814962d3ac220"}}, "title": "Symptom clusters in COVID-19: A potential clinical prediction tool from the COVID Symptom Study app.", "authors": [{"family": "Sudre", "given": "Carole H", "initials": "CH", "orcid": "0000-0001-5753-428X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c26472813fed4007a8757af771de1802.json"}}, {"family": "Lee", "given": "Karla A", "initials": "KA"}, {"family": "Lochlainn", "given": "Mary Ni", "initials": "MN", "orcid": "0000-0001-5702-1759", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07cc5b481cc441988525d0a1b2911a6d.json"}}, {"family": "Varsavsky", "given": "Thomas", "initials": "T"}, {"family": "Murray", "given": "Benjamin", "initials": "B", "orcid": "0000-0002-2413-923X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebec738df0224bf4874fd6c08fd23fae.json"}}, {"family": "Graham", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-4170-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f5f4e19812a46ed9e873732ec25e28d.json"}}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874802ae65824a90ba50eabdeabb8356.json"}}, {"family": "Modat", "given": "Marc", "initials": "M"}, {"family": "Bowyer", "given": "Ruth C E", "initials": "RCE"}, {"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Drew", "given": "David A", "initials": "DA", "orcid": "0000-0002-8813-0816", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd3a2cffdc104f18b8684cf4f27d68b2.json"}}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Ma", "given": "Wenjie", "initials": "W", "orcid": "0000-0001-9894-7072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc7d1aa610c04d67bd6c9b57b34b5ace.json"}}, {"family": "Guo", "given": "Chuan-Guo", "initials": "CG", "orcid": "0000-0002-0657-473X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1be56974ac7414e9db038e4e8c43982.json"}}, {"family": "Lo", "given": "Chun-Han", "initials": "CH", "orcid": "0000-0001-8202-4513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a0d9111318f4084b64f47b5b56c8c85.json"}}, {"family": "Ganesh", "given": "Sajaysurya", "initials": "S", "orcid": "0000-0002-3720-4176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6dbf91180806442082ce6732c1b75923.json"}}, {"family": "Buwe", "given": "Abubakar", "initials": "A", "orcid": "0000-0003-4086-8616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeba04fb389b4d2d8c0e9b29f4424d73.json"}}, {"family": "Pujol", "given": "Joan Capdevila", "initials": "JC"}, {"family": "du Cadet", "given": "Julien Lavigne", "initials": "JL", "orcid": "0000-0001-8034-7167", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd59698f58fa4129a5d07a8315c0c81b.json"}}, {"family": "Visconti", "given": "Alessia", "initials": "A", "orcid": "0000-0003-4144-2019", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ce0429ccf674827aedbb8d05a53145c.json"}}, {"family": "Freidin", "given": "Maxim B", "initials": "MB", "orcid": "0000-0002-1439-6259", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/978702cb6b4c44d7aaa5839543afa5df.json"}}, {"family": "El-Sayed Moustafa", "given": "Julia S", "initials": "JS", "orcid": "0000-0001-6963-6654", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b121ad24f0349a08b785a24a7a1ee3e.json"}}, {"family": "Falchi", "given": "Mario", "initials": "M", "orcid": "0000-0002-5646-1004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0a8220dcbcf45278fa264e153f97650.json"}}, {"family": "Davies", "given": "Richard", "initials": "R", "orcid": "0000-0003-2050-3994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b82cc92615f462d9af0153a6fb94fde.json"}}, {"family": "Gomez", "given": "Maria F", "initials": "MF", "orcid": "0000-0001-6210-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e09e37219c4f42c8a7b3a982da523859.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f34c0d3602439abe6096293c7c732d.json"}}, {"family": "Cardoso", "given": "M Jorge", "initials": "MJ", "orcid": "0000-0003-1284-2558", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0ed3abec67644e186650e1d1dcbbe0b.json"}}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74cf1f7094744ee289fa5df041e7cb5b.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-7284-6767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeefbf47fd384d5390109fe1a903bd18.json"}}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}, {"family": "Ourselin", "given": "S\u00e9bastien", "initials": "S", "orcid": "0000-0002-5694-5340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74c7b9b1633144879042d198c7205656.json"}}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "7", "issue": "12", "issn-l": "2375-2548"}, "abstract": "As no one symptom can predict disease severity or the need for dedicated medical support in coronavirus disease 2019 (COVID-19), we asked whether documenting symptom time series over the first few days informs outcome. Unsupervised time series clustering over symptom presentation was performed on data collected from a training dataset of completed cases enlisted early from the COVID Symptom Study Smartphone application, yielding six distinct symptom presentations. Clustering was validated on an independent replication dataset between 1 and 28 May 2020. Using the first 5 days of symptom logging, the ROC-AUC (receiver operating characteristic - area under the curve) of need for respiratory support was 78.8%, substantially outperforming personal characteristics alone (ROC-AUC 69.5%). Such an approach could be used to monitor at-risk patients and predict medical resource requirements days before they are required.", "doi": "10.1126/sciadv.abd4177", "pmid": "33741586", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7978420"}, {"db": "pii", "key": "7/12/eabd4177"}], "notes": [], "created": "2021-03-22T10:31:12.422Z", "modified": "2023-06-19T15:27:39.430Z"}, {"entity": "publication", "iuid": "de99b38176ee4b739ce67799af265121", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/de99b38176ee4b739ce67799af265121.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/de99b38176ee4b739ce67799af265121"}}, "title": "Sweden: Non-binding Rules against the Pandemic - Formalism, Pragmatism and Some Legal Realism.", "authors": [{"family": "Wenander", "given": "Henrik", "initials": "H"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Eur J Risk Regul", "issn": "1867-299X", "issn-l": null, "volume": "12", "issue": "1", "pages": "127-142"}, "abstract": "Swedish measures to fight the spread of COVID-19 differ from the strategies used in other comparable countries. In contrast to the lockdown approach that has been applied in many European countries, the Swedish strategy has been based to a substantial extent on individuals taking responsibility under non-binding recommendations. This contribution explores the Swedish strategy from a constitutional and administrative law perspective, highlighting the tension between the formalist system for delegating norms under the Swedish Constitution and the pragmatic use of non-binding rules such as the \"General Recommendations\" adopted by the Public Health Agency. The article concludes that the official use of soft law instruments is confusing from a legal perspective, because non-binding rules do not offer the traditional formal mechanisms for legal protection, the publication of norms or accountability. The legal-realist approach of the Supreme Administrative Court's case law, however, has the potential of balancing some of the unfortunate effects arising from the Swedish combination of formalism and pragmatism.", "doi": "10.1017/err.2021.2", "pmid": "34191958", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S1867299X21000027"}, {"db": "pmc", "key": "PMC8060606"}], "notes": [], "created": "2021-07-05T14:25:58.305Z", "modified": "2022-11-23T09:02:34.506Z"}, {"entity": "publication", "iuid": "90e7835a18214ccabf92e7659c5a9709", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90e7835a18214ccabf92e7659c5a9709.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90e7835a18214ccabf92e7659c5a9709"}}, "title": "Shared genetic etiology between idiopathic pulmonary fibrosis and COVID-19 severity", "authors": [{"family": "Fadista", "given": "Jo\u00e3o", "initials": "J", "orcid": "0000-0003-2539-634X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dae453c1a93e417caeb346ac4cdc48ed.json"}}, {"family": "Kraven", "given": "Luke M", "initials": "LM"}, {"family": "Karjalainen", "given": "Juha", "initials": "J"}, {"family": "Andrews", "given": "Shea J", "initials": "SJ"}, {"family": "Geller", "given": "Frank", "initials": "F"}, {"family": "Baillie", "given": "J Kenneth", "initials": "JK"}, {"family": "Wain", "given": "Louise V", "initials": "LV"}, {"family": "Jenkins", "given": "R Gisli", "initials": "RG"}, {"family": "Feenstra", "given": "Bjarke", "initials": "B"}], "type": "journal-article", "published": "2021-03-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": "65", "issue": null, "pages": "103277"}, "abstract": "Idiopathic pulmonary fibrosis (IPF) is a complex lung disease, characterized by progressive lung scarring. Severe COVID-19 is associated with substantial pneumonitis and has a number of shared major risk factors with IPF. This study aimed to determine the genetic correlation between IPF and severe COVID-19 and assess a potential causal role of genetically increased risk of IPF on COVID-19 severity.\r\n\r\nThe genetic correlation between IPF and COVID-19 severity was estimated with linkage disequilibrium (LD) score regression. We performed a Mendelian randomization (MR) study for IPF causality in COVID-19. Genetic variants associated with IPF susceptibility (P<5 \u00d7 10 -8) in previous genome-wide association studies (GWAS) were used as instrumental variables (IVs). Effect estimates of those IVs on COVID-19 severity were gathered from the GWAS meta-analysis by the COVID-19 Host Genetics Initiative (4,336 cases & 623,902 controls).\r\n\r\nWe detected a positive genetic correlation of IPF with COVID-19 severity (rg=0\u00b731 [95% CI 0\u00b704-0\u00b757], P = 0\u00b7023). The MR estimates for severe COVID-19 did not reveal any genetic association (OR 1\u00b705, [95% CI 0\u00b792-1\u00b720], P = 0\u00b743). However, outlier analysis revealed that the IPF risk allele rs35705950 at MUC5B had a different effect compared with the other variants. When rs35705950 was excluded, MR results provided evidence that genetically increased risk of IPF has a causal effect on COVID-19 severity (OR 1\u00b721, [95% CI 1\u00b706-1\u00b738], P = 4\u00b724 \u00d7 10 -3). Furthermore, the IPF risk-allele at MUC5B showed an apparent protective effect against COVID-19 hospitalization only in older adults (OR 0\u00b786, [95% CI 0\u00b773-1\u00b700], P = 2\u00b799 \u00d7 10-2) .\r\n\r\nThe strongest genetic determinant of IPF, rs35705950 at MUC5B, seems to confer protection against COVID-19, whereas the combined effect of all other IPF risk loci seem to confer risk of COVID-19 severity. The observed effect of rs35705950 could either be due to protective effects of mucin over-production on the airways or a consequence of selection bias due to (1) a patient group that is heavily enriched for the rs35705950 T undertaking strict self-isolation and/or (2) due to survival bias of the rs35705950 non-IPF risk allele carriers. Due to the diverse impact of IPF causal variants on SARS-CoV-2 infection, with a possible selection bias as an explanation, further investigation is needed to address this apparent paradox between variance at MUC5B and other IPF genetic risk factors.\r\n\r\nNovo Nordisk Foundation and Oak Foundation.", "doi": "10.1016/j.ebiom.2021.103277", "pmid": "33714028", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "URL", "key": "https://github.com/genomicsITER/PFgenetics", "description": "Variant summary data available on request"}, {"db": "URL", "key": "https://www.covid19hg.org/results/", "description": "COVID-19 Host Genetics Initiative (HGI) GWAS metaanalysis"}], "notes": [], "created": "2021-01-07T16:51:10.098Z", "modified": "2022-07-07T09:55:41.690Z"}, {"entity": "publication", "iuid": "94f5f09c0d0e43ba9e96d2a5e95d0ed4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/94f5f09c0d0e43ba9e96d2a5e95d0ed4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/94f5f09c0d0e43ba9e96d2a5e95d0ed4"}}, "title": "Risk prediction of COVID-19 incidence and mortality in a large multi-national hemodialysis cohort: implications for management of the pandemic in outpatient hemodialysis settings.", "authors": [{"family": "Haarhaus", "given": "Mathias", "initials": "M"}, {"family": "Santos", "given": "Carla", "initials": "C"}, {"family": "Haase", "given": "Michael", "initials": "M"}, {"family": "Mota Veiga", "given": "Pedro", "initials": "P"}, {"family": "Lucas", "given": "Carlos", "initials": "C"}, {"family": "Macario", "given": "Fernando", "initials": "F"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Clin Kidney J", "issn": "2048-8505", "volume": "14", "issue": "3", "pages": "805-813", "issn-l": null}, "abstract": "Experiences from the first wave of the 2019 coronavirus disease (COVID-19) pandemic can aid in the development of future preventive strategies. To date, risk prediction models for COVID-19-related incidence and outcomes in hemodialysis (HD) patients are missing.\n\nWe developed risk prediction models for COVID-19 incidence and mortality among HD patients. We studied 38 256 HD patients from a multi-national dialysis cohort between 3 March and 3 July 2020. Risk prediction models were developed and validated, based on predictors readily available in outpatient HD units. We compared mortality among patients with and without COVID-19, matched for age, sex and diabetes.\n\nDuring the observational period, 1259 patients (3.3%) acquired COVID-19. Of these, 62% were hospitalized or died. Mortality was 22% among COVID-19 patients with odds ratios 219.8 [95% confidence interval (CI) 80.6-359] to 342.7 (95% CI 60.6-13 595.1), compared to matched patients without COVID-19. Since the first wave of the pandemic affected most European countries during the study, the risk prediction model for incidence of COVID-19 was developed and validated in European patients only [ N = 22 826 area under the ROC curve(AUC)Dev 0.64, AUCVal 0.69]. The model for prediction of mortality was developed in all COVID-19 patients (AUCDev 0.71, AUCVal 0.78). Angiotensin receptor blockers were independently associated with a lower incidence of COVID-19 in European patients.\n\nWe identified modifiable risk factors for COVID-19 incidence and outcome in HD patients. Our risk prediction tools can be readily applied in clinical practice. This can aid in the development of preventive strategies for future waves of COVID-19.", "doi": "10.1093/ckj/sfab037", "pmid": "33777363", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "sfab037"}, {"db": "pmc", "key": "PMC7929029"}], "notes": [], "created": "2021-03-30T12:25:19.508Z", "modified": "2021-03-30T12:25:19.524Z"}, {"entity": "publication", "iuid": "c58d689fb71f4c4b80daabc3511108e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c58d689fb71f4c4b80daabc3511108e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c58d689fb71f4c4b80daabc3511108e8"}}, "title": "Risk factors for COVID-19 diagnosis, hospitalization, and subsequent all-cause mortality in Sweden: a nationwide study.", "authors": [{"family": "Bergman", "given": "Jonathan", "initials": "J", "orcid": "0000-0003-1904-6140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/da94cb04b9114549bcc1775090d0de61.json"}}, {"family": "Ballin", "given": "Marcel", "initials": "M", "orcid": "0000-0002-9638-7208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/088ce3ef36e347ebb3a4f90d8e6a1850.json"}}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A", "orcid": "0000-0003-3534-456X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26229455bc3d42f6aea6b541c4d74b48.json"}}, {"family": "Nordstr\u00f6m", "given": "Peter", "initials": "P", "orcid": "0000-0003-2924-508X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1186e45ff19c4b30888c4751faea3c15.json"}}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Eur J Epidemiol", "issn": "1573-7284", "issn-l": "0393-2990", "volume": "36", "issue": "3", "pages": "287-298"}, "abstract": "We conducted a nationwide, registry-based study to investigate the importance of 34 potential risk factors for coronavirus disease 2019 (COVID-19) diagnosis, hospitalization (with or without intensive care unit [ICU] admission), and subsequent all-cause mortality. The study population comprised all COVID-19 cases confirmed in Sweden by mid-September 2020 (68,575 non-hospitalized, 2494 ICU hospitalized, and 13,589 non-ICU hospitalized) and 434,081 randomly sampled general-population controls. Older age was the strongest risk factor for hospitalization, although the odds of ICU hospitalization decreased after 60-69 years and, after controlling for other risk factors, the odds of non-ICU hospitalization showed no trend after 40-49 years. Residence in a long-term care facility was associated with non-ICU hospitalization. Male sex and the presence of at least one investigated comorbidity or prescription medication were associated with both ICU and non-ICU hospitalization. Three comorbidities associated with both ICU and non-ICU hospitalization were asthma, hypertension, and Down syndrome. History of cancer was not associated with COVID-19 hospitalization, but cancer in the past year was associated with non-ICU hospitalization, after controlling for other risk factors. Cardiovascular disease was weakly associated with non-ICU hospitalization for COVID-19, but not with ICU hospitalization, after adjustment for other risk factors. Excess mortality was observed in both hospitalized and non-hospitalized COVID-19 cases. These results confirm that severe COVID-19 is related to age, sex, and comorbidity in general. The study provides new evidence that hypertension, asthma, Down syndrome, and residence in a long-term care facility are associated with severe COVID-19.", "doi": "10.1007/s10654-021-00732-w", "pmid": "33704634", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7946619"}, {"db": "pii", "key": "10.1007/s10654-021-00732-w"}], "notes": [], "created": "2021-03-12T06:42:36.663Z", "modified": "2023-07-13T11:27:54.874Z"}, {"entity": "publication", "iuid": "60be0de57e6441208b155f92091e203b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60be0de57e6441208b155f92091e203b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60be0de57e6441208b155f92091e203b"}}, "title": "Noise measurements as a proxy to evaluating the response to recommendations in times of crisis: An update analysis of the transition to the second wave of the CoViD-19 pandemic in Central Stockholm, Sweden.", "authors": [{"family": "Rumpler", "given": "Romain", "initials": "R"}, {"family": "Venkataraman", "given": "Siddharth", "initials": "S"}, {"family": "G\u00f6ransson", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "J Acoust Soc Am", "issn": "1520-8524", "volume": "149", "issue": "3", "pages": "1838", "issn-l": null}, "abstract": "Sweden stands out among the other European countries by the degree of restrictive measures taken towards handling the 2019 coronavirus outbreak, associated with the CoViD-19 pandemic. While several governments have imposed a nationwide total or partial lockdown to slow down the spread of the virus, the Swedish government has opted for a recommendation-based approach together with a few imposed restrictions. In a previous contribution by the authors, the impact of the Swedish strategy was observed through the monitored variation of the city noise levels during a period associated with the so-called \"first wave\" of the pandemic in Stockholm. A very strong impact of these recommendations was shown on the evolution of the noise levels in central Stockholm. This highlighted the potential of acoustic sensor networks both for enforcement of regulation and monitoring of the effectiveness of their implementation. The present contribution presents a follow-up to this urban noise monitoring in central Stockholm, Sweden, for the period leading to the so-called \"second wave\" of the pandemic in Europe. Both the evolution of adherence to the recommendations and the impact of the recurrence of cases combined with reinforced recommendations are observed through the evolution of the measured noise levels. While the measurements show a gradual lower level of compliance, in particular, past the summer break, these also show again a rapid response to the reinforced recommendations issued by the authorities in mid-fall of 2020. These observations thus confirm the potential associated with detailed urban noise monitoring, for instance here acting as a proxy to evaluating the response to recommendations or restrictions in times of crisis.", "doi": "10.1121/10.0003778", "pmid": "33765773", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-03-29T09:15:50.369Z", "modified": "2021-03-29T09:15:50.385Z"}, {"entity": "publication", "iuid": "4a726c03e1814efc87b21b7679305fcc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4a726c03e1814efc87b21b7679305fcc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4a726c03e1814efc87b21b7679305fcc"}}, "title": "Monitoring of human coronaviruses in Belgian primary care and hospitals, 2015\u201320: a surveillance study", "authors": [{"family": "Fischer", "given": "Natalie", "initials": "N"}, {"family": "Dauby", "given": "Nicolas", "initials": "N"}, {"family": "Bossuyt", "given": "Nathalie", "initials": "N"}, {"family": "Reynders", "given": "Marijke", "initials": "M"}, {"family": "G\u00e9rard", "given": "Mich\u00e8le", "initials": "M"}, {"family": "Lacor", "given": "Patrick", "initials": "P"}, {"family": "Daelemans", "given": "Siel", "initials": "S"}, {"family": "Lissoir", "given": "B\u00e9n\u00e9dicte", "initials": "B"}, {"family": "Holemans", "given": "Xavier", "initials": "X"}, {"family": "Magerman", "given": "Koen", "initials": "K"}, {"family": "Jouck", "given": "Door", "initials": "D"}, {"family": "Bourgeois", "given": "Marc", "initials": "M"}, {"family": "Delaere", "given": "B\u00e9n\u00e9dicte", "initials": "B"}, {"family": "Quoilin", "given": "Sophie", "initials": "S"}, {"family": "Van Gucht", "given": "Steven", "initials": "S"}, {"family": "Thomas", "given": "Isabelle", "initials": "I"}, {"family": "Barbezange", "given": "Cyril", "initials": "C"}, {"family": "Subissi", "given": "Lorenzo", "initials": "L"}], "type": "journal-article", "published": "2021-03-00", "journal": {"title": "The Lancet Microbe", "issn": "2666-5247", "issn-l": "2666-5247", "volume": "2", "issue": "3", "pages": "e105-e114"}, "abstract": "Seasonal human coronaviruses (hCoVs) broadly circulate in humans. Their epidemiology and effect on the spread of emerging coronaviruses has been neglected thus far. We aimed to elucidate the epidemiology and burden of disease of seasonal hCoVs OC43, NL63, and 229E in patients in primary care and hospitals in Belgium between 2015 and 2020.\r\n\r\nWe retrospectively analysed data from the national influenza surveillance networks in Belgium during the winter seasons of 2015-20. Respiratory specimens were collected through the severe acute respiratory infection (SARI) and the influenza-like illness networks from patients with acute respiratory illness with onset within the previous 10 days, with measured or reported fever of 38\u00b0C or greater, cough, or dyspnoea; and for patients admitted to hospital for at least one night. Potential risk factors were recorded and patients who were admitted to hospital were followed up for the occurrence of complications or death for the length of their hospital stay. All samples were analysed by multiplex quantitative RT-PCRs for respiratory viruses, including seasonal hCoVs OC43, NL63, and 229E. We estimated the prevalence and incidence of seasonal hCoV infection, with or without co-infection with other respiratory viruses. We evaluated the association between co-infections and potential risk factors with complications or death in patients admitted to hospital with seasonal hCoV infections by age group. Samples received from week 8, 2020, were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).\r\n\r\n2573 primary care and 6494 hospital samples were included in the study. 161 (6\u00b73%) of 2573 patients in primary care and 371 (5\u00b77%) of 6494 patients admitted to hospital were infected with a seasonal hCoV. OC43 was the seasonal hCoV with the highest prevalence across age groups and highest incidence in children admitted to hospital who were younger than 5 years (incidence 9\u00b70 [95% CI 7\u00b72-11\u00b72] per 100 000 person-months) and adults older than 65 years (2\u00b76 [2\u00b71-3\u00b72] per 100 000 person-months). Among 262 patients admitted to hospital with seasonal hCoV infection and with complete information on potential risk factors, 66 (73\u00b73%) of 90 patients who had complications or died also had at least one potential risk factor (p=0\u00b70064). Complications in children younger than 5 years were associated with co-infection (24 [36\u00b74%] of 66; p=0\u00b7017), and in teenagers and adults (\u226515 years), more complications arose in patients with a single hCoV infection (49 [45\u00b70%] of 109; p=0\u00b70097). In early 2020, the Belgian SARI surveillance detected the first SARS-CoV-2-positive sample concomitantly with the first confirmed COVID-19 case with no travel history to China.\r\n\r\nThe main burden of severe seasonal hCoV infection lies with children younger than 5 years with co-infections and adults aged 65 years and older with pre-existing comorbidities. These age and patient groups should be targeted for enhanced observation when in medical care and in possible future vaccination strategies, and co-infections in children younger than 5 years should be considered during diagnosis and treatment. Our findings support the use of national influenza surveillance systems for seasonal hCoV monitoring and early detection, and monitoring of emerging coronaviruses such as SARS-CoV-2.\r\n\r\nBelgian Federal Public Service Health, Food Chain Safety, and Environment; Belgian National Insurance Health Care (Institut national d'assurance maladie-invalidit\u00e9/Rijksinstituut voor ziekte-en invaliditeitsverzekering); and Regional Health Authorities (Flanders Agentschap zorg en gezondheid, Brussels Commission communautaire commune, Wallonia Agence pour une vie de qualit\u00e9).", "doi": "10.1016/s2666-5247(20)30221-4", "pmid": "33937883", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-05-04T15:57:48.285Z", "modified": "2021-06-18T14:46:29.690Z"}, {"entity": "publication", "iuid": "101f86cc435f4e869f06e10bc5689df5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/101f86cc435f4e869f06e10bc5689df5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/101f86cc435f4e869f06e10bc5689df5"}}, "title": "Interactions between seasonal human coronaviruses and implications for the SARS-CoV-2 pandemic: A retrospective study in Stockholm, Sweden, 2009-2020.", "authors": [{"family": "Dyrdak", "given": "Robert", "initials": "R", "orcid": "0000-0001-8456-4898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98ad76a0e144478cb3ceabd05c9928b0.json"}}, {"family": "Hodcroft", "given": "Emma B", "initials": "EB", "orcid": "0000-0002-0078-2212", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/563993c9fb68466c8867ca7600733548.json"}}, {"family": "Wahlund", "given": "Martina", "initials": "M"}, {"family": "Neher", "given": "Richard A", "initials": "RA", "orcid": "0000-0003-2525-1407", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a31564f19214fbdb275578ed05a6bcb.json"}}, {"family": "Albert", "given": "Jan", "initials": "J", "orcid": "0000-0001-9020-0521", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79a6c7eedadb4a1e8c6fd7b8b522a8e3.json"}}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "J Clin Virol", "issn": "1873-5967", "volume": "136", "issue": null, "pages": "104754", "issn-l": null}, "abstract": "The four seasonal coronaviruses 229E, NL63, OC43, and HKU1 are frequent causes of respiratory infections and show annual and seasonal variation. Increased understanding about these patterns could be informative about the epidemiology of SARS-CoV-2.\n\nResults from PCR diagnostics for the seasonal coronaviruses, and other respiratory viruses, were obtained for 55,190 clinical samples analyzed at the Karolinska University Hospital, Stockholm, Sweden, between 14 September 2009 and 2 April 2020.\n\nSeasonal coronaviruses were detected in 2130 samples (3.9 %) and constituted 8.1 % of all virus detections. OC43 was most commonly detected (28.4 % of detections), followed by NL63 (24.0 %), HKU1 (17.6 %), and 229E (15.3 %). The overall fraction of positive samples was similar between seasons, but at species level there were distinct biennial alternating peak seasons for the Alphacoronaviruses, 229E and NL63, and the Betacoronaviruses, OC43 and HKU1, respectively. The Betacoronaviruses peaked earlier in the winter season (Dec-Jan) than the Alphacoronaviruses (Feb-Mar). Coronaviruses were detected across all ages, but diagnostics were more frequently requested for paediatric patients than adults and the elderly. OC43 and 229E incidence was relatively constant across age strata, while that of NL63 and HKU1 decreased with age.\n\nBoth the Alphacoronaviruses and Betacoronaviruses showed alternating biennial winter incidence peaks, which suggests some type of immune mediated interaction. Symptomatic reinfections in adults and the elderly appear relatively common. Both findings may be of relevance for the epidemiology of SARS-CoV-2.", "doi": "10.1016/j.jcv.2021.104754", "pmid": "33601153", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pmc", "key": "PMC7869750"}, {"db": "pii", "key": "S1386-6532(21)00021-4"}], "notes": [], "created": "2021-02-19T14:05:54.744Z", "modified": "2023-06-19T14:44:22.357Z"}, {"entity": "publication", "iuid": "7d04c0dd10e84d5a812d21d4b41b5fd2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d04c0dd10e84d5a812d21d4b41b5fd2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d04c0dd10e84d5a812d21d4b41b5fd2"}}, "title": "Global Tuberculosis Report 2020 \u2013 Reflections on the Global TB burden, treatment and prevention efforts", "authors": [{"family": "Chakaya", "given": "Jeremiah", "initials": "J"}, {"family": "Khan", "given": "Mishal", "initials": "M"}, {"family": "Ntoumi", "given": "Francine", "initials": "F"}, {"family": "Aklillu", "given": "Eleni", "initials": "E"}, {"family": "Fatima", "given": "Razia", "initials": "R"}, {"family": "Mwaba", "given": "Peter", "initials": "P"}, {"family": "Kapata", "given": "Nathan", "initials": "N"}, {"family": "Mfinanga", "given": "Sayoki", "initials": "S"}, {"family": "Hasnain", "given": "Seyed Ehtesham", "initials": "SE"}, {"family": "Katoto", "given": "Patrick D M C", "initials": "PDMC"}, {"family": "Bulabula", "given": "Andr\u00e9 N H", "initials": "ANH"}, {"family": "Sam-Agudu", "given": "Nadia A", "initials": "NA"}, {"family": "Nachega", "given": "Jean B", "initials": "JB"}, {"family": "Tiberi", "given": "Simon", "initials": "S"}, {"family": "McHugh", "given": "Timothy D", "initials": "TD"}, {"family": "Abubakar", "given": "Ibrahim", "initials": "I"}, {"family": "Zumla", "given": "Alimuddin", "initials": "A"}], "type": "journal-article", "published": "2021-03-00", "journal": {"title": "Int J Infect Dis", "issn": "1201-9712", "volume": null, "issue": null, "issn-l": null}, "abstract": "The October 2020 Global TB report reviews TB control strategies and United Nations (UN) targets set in the political declaration at the September 2018 UN General Assembly high-level meeting on TB held in New York. Progress in TB care and prevention has been very slow. In 2019, TB remained the most common cause of death from a single infectious pathogen. Globally, an estimated 10.0 million people developed TB disease in 2019, and there were an estimated 1.2 million TB deaths among HIV-negative people and an additional 208, 000 deaths among people living with HIV. Adults accounted for 88% and children for 12% of people with TB. The WHO regions of South-East Asia (44%), Africa (25%), and the Western Pacific (18%) had the most people with TB. Eight countries accounted for two thirds of the global total: India (26%), Indonesia (8.5%), China (8.4%), the Philippines (6.0%), Pakistan (5.7%), Nigeria (4.4%), Bangladesh (3.6%) and South Africa (3.6%). Only 30% of the 3.5 million five-year target for children treated for TB was met. Major advances have been development of new all oral regimens for MDRTB and new regimens for preventive therapy. In 2020, the COVID-19 pandemic dislodged TB from the top infectious disease cause of mortality globally. Notably, global TB control efforts were not on track even before the advent of the COVID-19 pandemic. Many challenges remain to improve sub-optimal TB treatment and prevention services. Tuberculosis screening and diagnostic test services need to be ramped up. The major drivers of TB remain undernutrition, poverty, diabetes, tobacco smoking, and household air pollution and these need be addressed to achieve the WHO 2035 TB care and prevention targets. National programs need to include interventions for post-tuberculosis holistic wellbeing. From first detection of COVID-19 global coordination and political will with huge financial investments have led to the development of effective vaccines against SARS-CoV2 infection. The world now needs to similarly focus on development of new vaccines for TB utilizing new technological methods.", "doi": "10.1016/j.ijid.2021.02.107", "pmid": "33716195", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)00193-4"}], "notes": [], "created": "2021-03-17T07:44:20.760Z", "modified": "2021-11-18T12:57:11.611Z"}, {"entity": "publication", "iuid": "32060e12cef54c949408c3780679c265", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/32060e12cef54c949408c3780679c265.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/32060e12cef54c949408c3780679c265"}}, "title": "Emerging COVID-19 impacts, responses, and lessons for building resilience in the seafood system.", "authors": [{"family": "Love", "given": "David C", "initials": "DC"}, {"family": "Allison", "given": "Edward H", "initials": "EH"}, {"family": "Asche", "given": "Frank", "initials": "F"}, {"family": "Belton", "given": "Ben", "initials": "B"}, {"family": "Cottrell", "given": "Richard S", "initials": "RS"}, {"family": "Froehlich", "given": "Halley E", "initials": "HE"}, {"family": "Gephart", "given": "Jessica A", "initials": "JA"}, {"family": "Hicks", "given": "Christina C", "initials": "CC"}, {"family": "Little", "given": "David C", "initials": "DC"}, {"family": "Nussbaumer", "given": "Elizabeth M", "initials": "EM"}, {"family": "Pinto da Silva", "given": "Patricia", "initials": "P"}, {"family": "Poulain", "given": "Florence", "initials": "F"}, {"family": "Rubio", "given": "Angel", "initials": "A"}, {"family": "Stoll", "given": "Joshua S", "initials": "JS"}, {"family": "Tlusty", "given": "Michael F", "initials": "MF"}, {"family": "Thorne-Lyman", "given": "Andrew L", "initials": "AL"}, {"family": "Troell", "given": "Max", "initials": "M"}, {"family": "Zhang", "given": "Wenbo", "initials": "W"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Glob Food Sec", "issn": "2211-9124", "volume": "28", "pages": "100494", "issn-l": null}, "abstract": "The COVID-19 pandemic and subsequent lockdowns are creating health and economic crises that threaten food and nutrition security. The seafood sector provides important sources of nutrition and employment, especially in low-income countries, and is highly globalized allowing shocks to propagate. We studied COVID-19-related disruptions, impacts, and responses to the seafood sector from January through May 2020, using a food system resilience 'action cycle' framework as a guide. We find that some supply chains, market segments, companies, small-scale actors and civil society have shown initial signs of greater resilience than others. COVID-19 has also highlighted the vulnerability of certain groups working in- or dependent on the seafood sector. We discuss early coping and adaptive responses combined with lessons from past shocks that could be considered when building resilience in the sector. We end with strategic research needs to support learning from COVID-19 impacts and responses.", "doi": "10.1016/j.gfs.2021.100494", "pmid": "34513582", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2211-9124(21)00004-3"}, {"db": "pmc", "key": "PMC8417121"}], "notes": [], "created": "2021-09-20T06:33:28.865Z", "modified": "2021-09-20T06:33:28.892Z"}, {"entity": "publication", "iuid": "9931f188999f44fba834cbe17b7ac2d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9931f188999f44fba834cbe17b7ac2d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9931f188999f44fba834cbe17b7ac2d9"}}, "title": "COVID-19: cross-border contact tracing in Germany, February to April 2020.", "authors": [{"family": "Markus", "given": "Inessa", "initials": "I"}, {"family": "Steffen", "given": "Gyde", "initials": "G"}, {"family": "Lachmann", "given": "Raskit", "initials": "R"}, {"family": "Marquis", "given": "Adine", "initials": "A"}, {"family": "Schneider", "given": "Timm", "initials": "T"}, {"family": "Tomczyk", "given": "Sara", "initials": "S"}, {"family": "Koppe", "given": "Uwe", "initials": "U"}, {"family": "Rohde", "given": "Anna M", "initials": "AM"}, {"family": "Schink", "given": "Susanne Barbara", "initials": "SB"}, {"family": "Seifried", "given": "Janna", "initials": "J"}, {"family": "Domaszewska", "given": "Teresa", "initials": "T"}, {"family": "Rexroth", "given": "Ute", "initials": "U"}, {"family": "An der Heiden", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "10", "pages": null}, "abstract": "IntroductionThe Robert Koch Institute (RKI) managed the exchange of cross-border contact tracing data between public health authorities (PHA) in Germany and abroad during the early COVID-19 pandemic.AimWe describe the extent of cross-border contact tracing and its challenges.MethodsWe analysed cross-border COVID-19 contact tracing events from 3 February to 5 April 2020 using information exchanged through the European Early Warning Response System and communication with International Health Regulation national focal points. We described events by PHA, number of contacts and exposure context.ResultsThe RKI processed 467 events, initiating contact to PHA 1,099 times (median = 1; interquartile range (IQR): 1-2) and sharing data on 5,099 contact persons. Of 327 (70%) events with known exposure context, the most commonly reported exposures were aircraft (n = 64; 20%), cruise ships (n = 24; 7%) and non-transport contexts (n = 210; 64%). Cruise ship and aircraft exposures generated more contacts with authorities (median = 10; IQR: 2-16, median = 4; IQR: 2-11) and more contact persons (median = 60; IQR: 9-269, median = 2; IQR: 1-3) than non-transport exposures (median = 1; IQR: 1-6 and median = 1; IQR: 1-2). The median time spent on contact tracing was highest for cruise ships: 5 days (IQR: 3-9).ConclusionIn the COVID-19 pandemic, cross-border contact tracing is considered a critical component of the outbreak response. While only a minority of international contact tracing activities were related to exposure events in transport, they contributed substantially to the workload. The numerous communications highlight the need for fast and efficient global outbreak communication channels between PHA.", "doi": "10.2807/1560-7917.ES.2021.26.10.2001236", "pmid": "33706859", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-17T07:08:26.792Z", "modified": "2021-06-18T14:35:54.846Z"}, {"entity": "publication", "iuid": "fa577d8d62b147619aef4361d53d40ea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa577d8d62b147619aef4361d53d40ea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa577d8d62b147619aef4361d53d40ea"}}, "title": "ARIA-EAACI statement on asthma and COVID-19 (June 2, 2020).", "authors": [{"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Jutel", "given": "Marek", "initials": "M"}, {"family": "Akdis", "given": "Cezmi A", "initials": "CA", "orcid": "0000-0001-8020-019X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1c16696cf404e6ebd2a06c63b8d9849.json"}}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Pfaar", "given": "Oliver", "initials": "O", "orcid": "0000-0003-4374-9639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b23ecb478474bd18839b7ecaced7f08.json"}}, {"family": "Nadeau", "given": "Kari C", "initials": "KC", "orcid": "0000-0002-2146-2955", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/23da79d94ab448f49859abb68f851e31.json"}}, {"family": "Eiwegger", "given": "Thomas", "initials": "T", "orcid": "0000-0002-2914-7829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c90e67dd0a5451a9c95ea4570834cb9.json"}}, {"family": "Bedbrook", "given": "Anna", "initials": "A"}, {"family": "Ansotegui", "given": "Ignacio J", "initials": "IJ"}, {"family": "Anto", "given": "Josep M", "initials": "JM"}, {"family": "Bachert", "given": "Claus", "initials": "C", "orcid": "0000-0003-4742-1665", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac2485abcc7646aebe7330c514b47c29.json"}}, {"family": "Bateman", "given": "Eric D", "initials": "ED"}, {"family": "Bennoor", "given": "Kazi S", "initials": "KS"}, {"family": "Berghea", "given": "Elena Camelia", "initials": "EC"}, {"family": "Bergmann", "given": "Karl-Christian", "initials": "KC", "orcid": "0000-0002-0306-9922", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f09bd15c861743a7851bde407356fb6b.json"}}, {"family": "Blain", "given": "Hubert", "initials": "H"}, {"family": "Bonini", "given": "Mateo", "initials": "M", "orcid": "0000-0002-3042-0765", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb9057d6fa3d4f4ea86351af45ce21bc.json"}}, {"family": "Bosnic-Anticevich", "given": "Sinthia", "initials": "S"}, {"family": "Boulet", "given": "Louis-Philippe", "initials": "LP", "orcid": "0000-0003-3485-9393", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/997f95adb7f34198a9c837217332fae2.json"}}, {"family": "Brussino", "given": "Luisa", "initials": "L"}, {"family": "Buhl", "given": "Roland", "initials": "R"}, {"family": "Camargos", "given": "Paulo", "initials": "P"}, {"family": "Canonica", "given": "Giorgio Walter", "initials": "GW"}, {"family": "Cardona", "given": "Victoria", "initials": "V", "orcid": "0000-0003-2197-9767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80cffee5190f476d99c541a2282fd0d4.json"}}, {"family": "Casale", "given": "Thomas", "initials": "T", "orcid": "0000-0002-3149-7377", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba9ce0f5cdc4473395b7f0991abdc9ba.json"}}, {"family": "Chinthrajah", "given": "Sharon", "initials": "S"}, {"family": "Akdis", "given": "M\u00fcbeccel", "initials": "M", "orcid": "0000-0003-0554-9943", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3e08fc9040548058d7c21f7b3931dbe.json"}}, {"family": "Chivato", "given": "Tomas", "initials": "T"}, {"family": "Christoff", "given": "George", "initials": "G"}, {"family": "Cruz", "given": "Alvaro A", "initials": "AA", "orcid": "0000-0002-7403-3871", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/befa954a45424a7ea1b84e55e9bcdccb.json"}}, {"family": "Czarlewski", "given": "Wienczyslawa", "initials": "W"}, {"family": "Del Giacco", "given": "Stefano", "initials": "S"}, {"family": "Du", "given": "Hui", "initials": "H"}, {"family": "El-Gamal", "given": "Yehia", "initials": "Y"}, {"family": "Fokkens", "given": "Wytske J", "initials": "WJ", "orcid": "0000-0003-4852-229X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1a5bcdc04b0454392dbb1c6a9c003cf.json"}}, {"family": "Fonseca", "given": "Joao A", "initials": "JA"}, {"family": "Gao", "given": "Yadong", "initials": "Y"}, {"family": "Gaga", "given": "Mina", "initials": "M"}, {"family": "Gemicioglu", "given": "Bilun", "initials": "B"}, {"family": "Gotua", "given": "Maia", "initials": "M", "orcid": "0000-0003-2497-4128", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb1141c3d0e14b53a4c2dce6166d634a.json"}}, {"family": "Haahtela", "given": "Tari", "initials": "T", "orcid": "0000-0003-4757-2156", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/339da718bfb24a95b2920bc60429c314.json"}}, {"family": "Halpin", "given": "David", "initials": "D"}, {"family": "Hamelmann", "given": "Eckard", "initials": "E", "orcid": "0000-0002-2996-8248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e21761fe26845dbaa8d962408ad97ff.json"}}, {"family": "Hoffmann-Sommergruber", "given": "Karin", "initials": "K"}, {"family": "Humbert", "given": "Marc", "initials": "M"}, {"family": "Ilina", "given": "Nataliya", "initials": "N"}, {"family": "Ivancevich", "given": "Juan-Carlos", "initials": "JC"}, {"family": "Joos", "given": "Guy", "initials": "G"}, {"family": "Khaitov", "given": "Musa", "initials": "M"}, {"family": "Kirenga", "given": "Bruce", "initials": "B"}, {"family": "Knol", "given": "Edward F", "initials": "EF"}, {"family": "Ko", "given": "Fanny W", "initials": "FW"}, {"family": "Koskinen", "given": "Seppo", "initials": "S"}, {"family": "Kowalski", "given": "Marek L", "initials": "ML"}, {"family": "Kraxner", "given": "Helga", "initials": "H"}, {"family": "Kudlay", "given": "Dmitry", "initials": "D", "orcid": "0000-0003-1878-4467", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d3e6e559aae24655870f855046230f21.json"}}, {"family": "Kuna", "given": "Piotr", "initials": "P"}, {"family": "Kupczyk", "given": "Maciej", "initials": "M"}, {"family": "Kvedariene", "given": "Violeta", "initials": "V"}, {"family": "Abdul Latiff", "given": "Amir H", "initials": "AH"}, {"family": "Le", "given": "Lan T", "initials": "LT"}, {"family": "Levin", "given": "Michael", "initials": "M", "orcid": "0000-0003-2439-7981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56d68a2cbab745dd8745c99e6acea42f.json"}}, {"family": "Larenas-Linnemann", "given": "Desiree", "initials": "D", "orcid": "0000-0002-5713-5331", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8ffe8940cf9462e86211ff56b10528f.json"}}, {"family": "Louis", "given": "Renaud", "initials": "R"}, {"family": "Masjedi", "given": "Mohammad R", "initials": "MR"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Mihaltan", "given": "Florin", "initials": "F"}, {"family": "Milenkovic", "given": "Branislava", "initials": "B"}, {"family": "Mohammad", "given": "Yousser", "initials": "Y"}, {"family": "Morais-Almeida", "given": "Mario", "initials": "M", "orcid": "0000-0003-1837-2980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/642d46cfd0f54668a32f1baab68ba33d.json"}}, {"family": "Mullol", "given": "Joaquim", "initials": "J"}, {"family": "Namazova", "given": "Leyla", "initials": "L"}, {"family": "Neffen", "given": "Hugo", "initials": "H"}, {"family": "Nunes", "given": "Elisabete", "initials": "E"}, {"family": "O'Byrne", "given": "Paul", "initials": "P"}, {"family": "O'Hehir", "given": "Robyn", "initials": "R"}, {"family": "O'Mahony", "given": "Liam", "initials": "L"}, {"family": "Ohta", "given": "Ken", "initials": "K", "orcid": "0000-0001-9734-4579", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/465a0478a3b047ae8d6845f61380256d.json"}}, {"family": "Okamoto", "given": "Yoshitaka", "initials": "Y"}, {"family": "Onorato", "given": "Gabrielle L", "initials": "GL"}, {"family": "Panzner", "given": "Petr", "initials": "P"}, {"family": "Papadopoulos", "given": "Nikos G", "initials": "NG", "orcid": "0000-0002-4448-3468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c15c79dff08b458fa296e513201635be.json"}}, {"family": "Passalacqua", "given": "Gianni", "initials": "G", "orcid": "0000-0002-5139-3604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a7d959168ef499a8f2a2b576de11ad0.json"}}, {"family": "Patella", "given": "Vincenzo", "initials": "V", "orcid": "0000-0001-5640-6446", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/decdadd477b4440695714b4a9bbf609a.json"}}, {"family": "Pawankar", "given": "Ruby", "initials": "R"}, {"family": "Pham-Thi", "given": "Nh\u00e2n", "initials": "N"}, {"family": "Pigearias", "given": "Bernard", "initials": "B"}, {"family": "Popov", "given": "Todor A", "initials": "TA"}, {"family": "Puggioni", "given": "Francesca", "initials": "F"}, {"family": "Regateiro", "given": "Frederico S", "initials": "FS"}, {"family": "Rolla", "given": "Giovanni", "initials": "G"}, {"family": "Rottem", "given": "Menachem", "initials": "M"}, {"family": "Samolinski", "given": "Boleslaw", "initials": "B"}, {"family": "Sastre", "given": "Joaquin", "initials": "J", "orcid": "0000-0003-4689-6837", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03ef6cc3dbfb4764905e593f210e7759.json"}}, {"family": "Schwarze", "given": "Jurgen", "initials": "J"}, {"family": "Sheikh", "given": "Aziz", "initials": "A"}, {"family": "Scichilone", "given": "Nicola", "initials": "N"}, {"family": "Soto-Quiros", "given": "Manuel", "initials": "M"}, {"family": "Soto-Martinez", "given": "Manuel", "initials": "M"}, {"family": "Sova", "given": "Milan", "initials": "M"}, {"family": "Nicola", "given": "Stefania", "initials": "S"}, {"family": "Stelmach", "given": "Rafael", "initials": "R"}, {"family": "Suppli-Ulrik", "given": "Charlotte", "initials": "C"}, {"family": "Taborda-Barata", "given": "Luis", "initials": "L"}, {"family": "To", "given": "Teresa", "initials": "T"}, {"family": "Tomazic", "given": "Peter-Valentin", "initials": "PV", "orcid": "0000-0001-6445-4800", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e57596e0a1974baf85e37fcf8195f7b9.json"}}, {"family": "Toppila-Salmi", "given": "Sanna", "initials": "S", "orcid": "0000-0003-0890-6686", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d947e332e4341309f076161a3052a9d.json"}}, {"family": "Tsiligianni", "given": "Ioanna", "initials": "I"}, {"family": "Usmani", "given": "Omar", "initials": "O"}, {"family": "Valiulis", "given": "Arunas", "initials": "A"}, {"family": "Ventura", "given": "Maria Teresa", "initials": "MT"}, {"family": "Viegi", "given": "Giovanni", "initials": "G"}, {"family": "Vontetsianos", "given": "Theodor", "initials": "T"}, {"family": "Wang", "given": "De Yun", "initials": "Y"}, {"family": "Williams", "given": "Sian", "initials": "S"}, {"family": "Wong", "given": "Gary W K", "initials": "GWK", "orcid": "0000-0001-5939-812X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a7be3acc778435bb925e8c671876b8c.json"}}, {"family": "Yorgancioglu", "given": "Arzu", "initials": "A"}, {"family": "Zernotti", "given": "Mario", "initials": "M"}, {"family": "Zidarn", "given": "Mihaela", "initials": "M"}, {"family": "Zuberbier", "given": "Torsten", "initials": "T", "orcid": "0000-0002-1466-8875", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7dc091f64a240fd8fb6443292b812c6.json"}}, {"family": "Agache", "given": "Ioana", "initials": "I", "orcid": "0000-0001-7994-364X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25d9598f74414a38a868c2bcf545e94d.json"}}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": "76", "issue": "3", "pages": "689-697", "issn-l": "0105-4538"}, "abstract": null, "doi": "10.1111/all.14471", "pmid": "32588922", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7361514"}], "notes": [], "created": "2020-12-08T15:47:32.488Z", "modified": "2023-06-19T14:56:33.583Z"}, {"entity": "publication", "iuid": "fbd0f47a2fe447f4bbadac01d12693b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fbd0f47a2fe447f4bbadac01d12693b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fbd0f47a2fe447f4bbadac01d12693b1"}}, "title": "Racial and ethnic differences in COVID-19 vaccine hesitancy and uptake", "authors": [{"family": "Nguyen", "given": "Long H", "initials": "LH"}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Merino", "given": "Jordi", "initials": "J"}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Lo", "given": "Chun Han", "initials": "CH"}, {"family": "Kwon", "given": "Sohee", "initials": "S"}, {"family": "Wang", "given": "Kai", "initials": "K"}, {"family": "Graham", "given": "Mark S", "initials": "MS"}, {"family": "Polidori", "given": "Lorenzo", "initials": "L"}, {"family": "Menni", "given": "Cristina", "initials": "C"}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Anyane-Yeboa", "given": "Adjoa", "initials": "A"}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Warner", "given": "Erica T", "initials": "ET"}, {"family": "Hu", "given": "Christina Y", "initials": "CY"}, {"family": "Selvachandran", "given": "Somesh", "initials": "S"}, {"family": "Davies", "given": "Richard", "initials": "R"}, {"family": "Nash", "given": "Denis", "initials": "D"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Spector", "given": "Tim D", "initials": "TD"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}], "type": "posted-content", "published": "2021-02-28", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.25.21252402", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-10T15:04:30.526Z", "modified": "2021-03-12T10:08:58.796Z"}, {"entity": "publication", "iuid": "abda60f2e6fa4991907b165c02f376c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abda60f2e6fa4991907b165c02f376c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abda60f2e6fa4991907b165c02f376c5"}}, "title": "Changes of Gambling Patterns during COVID-19 in Sweden, and Potential for Preventive Policy Changes. A Second Look Nine Months into the Pandemic.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "Widinghoff", "given": "Carolina", "initials": "C"}], "type": "journal article", "published": "2021-02-27", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "5", "pages": null}, "abstract": "Gambling has been suggested as one of the potential mental health consequences of the COVID-19 pandemic. In earlier self-report studies, increased gambling has been reported by a limited proportion of respondents characterized with a high degree of problem gambling. The present study, carried out with the same methodology and in the same geographical setting, around seven months later in the pandemic, aimed to repeat and to extend the understanding of potential gambling changes in the population during COVID-19. An anonymous sample of web panel members was assessed, altogether 2029 individuals (52% women, 10% moderate-risk or problem gamblers). Results indicated that 6% reported increased gambling, and 4% reported decreased gambling during the pandemic. Having increased gambling was associated with more severe gambling problems (OR 2.78, 95% confidence interval 2.27-3.40), increased alcohol consumption (OR 2.92, 1.71-4.98), and psychological distress (OR 3.38, 1.83-6.23). In the group reporting increased gambling during COVID-19, moderate-risk/problem gambling was very common (62%). Recent governmental policy interventions in the area were known to a minority (30%) of respondents, but awareness of the regulations was markedly more common in individuals with at least moderate-risk gambling (56%) and in self-excluders (78%). Reporting of any perceived influence from policy changes was low (3%), and divided between those reporting an increasing and decreasing effect, respectively. Increased gambling may be a consequence of COVID-19-related changes in everyday lives of individuals with problematic gambling patterns. Thus, a vulnerable group demonstrates higher rates of gambling migration and psychosocial problems, and may require particular attention in screening and treatment contexts, and further scientific evaluations.", "doi": "10.3390/ijerph18052342", "pmid": "33673575", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph18052342"}], "notes": [], "created": "2021-03-08T10:53:43.655Z", "modified": "2021-06-18T14:31:03.572Z"}, {"entity": "publication", "iuid": "5d070ba5bf81463dbb738f0abdd09039", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d070ba5bf81463dbb738f0abdd09039.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d070ba5bf81463dbb738f0abdd09039"}}, "title": "COVID-19 Vaccines: Global Challenges and Prospects Forum Recommendations.", "authors": [{"family": "Boudjelal", "given": "Mohamed", "initials": "M"}, {"family": "Almajed", "given": "Faisal", "initials": "F"}, {"family": "Salman", "given": "Ahmed M", "initials": "AM"}, {"family": "Alharbi", "given": "Naif K", "initials": "NK"}, {"family": "Colangelo", "given": "Margaretta", "initials": "M"}, {"family": "Michelotti", "given": "Julia M", "initials": "JM"}, {"family": "Olinger", "given": "Gene", "initials": "G"}, {"family": "Baker", "given": "Mariwan", "initials": "M"}, {"family": "Hill", "given": "Adrian V S", "initials": "AVS"}, {"family": "Alaskar", "given": "Ahmed", "initials": "A"}], "type": "journal article", "published": "2021-02-27", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "volume": null, "issue": null, "issn-l": "1201-9712"}, "abstract": "Perspective On November 4 and 5, 2020 the 11 th Annual KAIMRC Global Forum was organized as a G20 related event entitled COVID-19 Vaccines: Global Challenges and Prospects, https://globalcovid19vaccines.com. It was a vital event that provided a hub for leading COVID-19 scientists, regulators, pharmaceutical representative, funders and charities to learn about COVID-19 vaccines in development, discuss different vaccine candidates, make recommendations, highlight lessons learned and address appropriate plans for global distribution and pricing. Over 10,000 people from 94 countries attended the forum. The leading COVID-19 vaccines presented use different technologies including: (a) Non-replicating viral vector based vaccines, ChAdOx1 nCoV-19/AZD1222 vaccine developed by Oxford-AstraZeneca (van Doremalen et al., 2020), the Sputnik V developed by the Russian Gamaleya Institute consisting of two components, a recombinant adenovirus type 26 (rAd26) vector and a recombinant adenovirus type 5 (rAd5) vector (Logunov et al., 2020), and the Ad26.COV2.S developed by Center for Virology and Vaccine Research, at Harvard Medical School in collaboration with Janssen Vaccines and Prevention BV, Leiden (Mercado et al., 2020). (b) Nucleic Acid, DNA- or RNA- based Vaccines that include the mRNA-1273 vaccine that is being developed by Moderna (Anderson et al., 2020), and a self-amplifying (saRNA) vaccine termed VGHsa111 developed by Imperial College, London as well as another co-developed by Pfizer and Biontech. An example of a DNA based vaccine against COVID19 is INO-4800 that is being developed by Inovio Pharmaceuticals Inc. (Smith et al., 2020). (c) Protein based vaccines, CoV RBD219-N1 Vaccine from Baylor College of Medicine, Texas that is based on a yeast-derived (Pichia pastoris) protein (Hotez and Bottazzi, 2020) and from Anhui Zhifei Longcom Biopharmaceutical Co. Ltd (Dai et al., 2020). Representatives from the Bill & Melinda Gates Foundation, the Bring Hope Humanitarian Foundation (BHHF), and the Coalition for Epidemic Preparedness Innovations (CEPI), presented their plans for distributing the vaccines to people in need around the world including the low-income countries. They are also developing educational programs to train health workers in immunization procedures.", "doi": "10.1016/j.ijid.2021.02.093", "pmid": "33652065", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)00179-X"}], "notes": [], "created": "2021-03-03T17:01:09.572Z", "modified": "2021-03-03T17:01:09.582Z"}, {"entity": "publication", "iuid": "3d00241e04a747daba93735a14a4a98a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3d00241e04a747daba93735a14a4a98a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3d00241e04a747daba93735a14a4a98a"}}, "title": "In silico Analyses of Immune System Protein Interactome Network, Single-Cell RNA Sequencing of Human Tissues, and Artificial Neural Networks Reveal Potential Therapeutic Targets for Drug Repurposing Against COVID-19.", "authors": [{"family": "L\u00f3pez-Cort\u00e9s", "given": "Andr\u00e9s", "initials": "A"}, {"family": "Guevara-Ram\u00edrez", "given": "Patricia", "initials": "P"}, {"family": "Kyriakidis", "given": "Nikolaos C", "initials": "NC"}, {"family": "Barba-Ostria", "given": "Carlos", "initials": "C"}, {"family": "Le\u00f3n C\u00e1ceres", "given": "\u00c1ngela", "initials": "\u00c1"}, {"family": "Guerrero", "given": "Santiago", "initials": "S"}, {"family": "Ortiz-Prado", "given": "Esteban", "initials": "E"}, {"family": "Munteanu", "given": "Cristian R", "initials": "CR"}, {"family": "Tejera", "given": "Eduardo", "initials": "E"}, {"family": "Cevallos-Robalino", "given": "Dom\u00e9nica", "initials": "D"}, {"family": "G\u00f3mez-Jaramillo", "given": "Ana Mar\u00eda", "initials": "AM"}, {"family": "Simba\u00f1a-Rivera", "given": "Katherine", "initials": "K"}, {"family": "Granizo-Mart\u00ednez", "given": "Adriana", "initials": "A"}, {"family": "P\u00e9rez-M", "given": "Gabriela", "initials": "G"}, {"family": "Moreno", "given": "Silvana", "initials": "S"}, {"family": "Garc\u00eda-C\u00e1rdenas", "given": "Jennyfer M", "initials": "JM"}, {"family": "Zambrano", "given": "Ana Karina", "initials": "AK"}, {"family": "P\u00e9rez-Castillo", "given": "Yunierkis", "initials": "Y"}, {"family": "Cabrera-Andrade", "given": "Alejandro", "initials": "A"}, {"family": "Puig San Andr\u00e9s", "given": "Lourdes", "initials": "L"}, {"family": "Proa\u00f1o-Castro", "given": "Carolina", "initials": "C"}, {"family": "Bautista", "given": "Jhommara", "initials": "J"}, {"family": "Quevedo", "given": "Andreina", "initials": "A"}, {"family": "Varela", "given": "Nelson", "initials": "N"}, {"family": "Qui\u00f1ones", "given": "Luis Abel", "initials": "LA"}, {"family": "Paz-Y-Mi\u00f1o", "given": "C\u00e9sar", "initials": "C"}], "type": "journal article", "published": "2021-02-26", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "12", "issue": null, "pages": "598925", "issn-l": "1663-9812"}, "abstract": "Background: There is pressing urgency to identify therapeutic targets and drugs that allow treating COVID-19 patients effectively. Methods: We performed in silico analyses of immune system protein interactome network, single-cell RNA sequencing of human tissues, and artificial neural networks to reveal potential therapeutic targets for drug repurposing against COVID-19. Results: We screened 1,584 high-confidence immune system proteins in ACE2 and TMPRSS2 co-expressing cells, finding 25 potential therapeutic targets significantly overexpressed in nasal goblet secretory cells, lung type II pneumocytes, and ileal absorptive enterocytes of patients with several immunopathologies. Then, we performed fully connected deep neural networks to find the best multitask classification model to predict the activity of 10,672 drugs, obtaining several approved drugs, compounds under investigation, and experimental compounds with the highest area under the receiver operating characteristics. Conclusion: After being effectively analyzed in clinical trials, these drugs can be considered for treatment of severe COVID-19 patients. Scripts can be downloaded at https://github.com/muntisa/immuno-drug-repurposing-COVID-19.", "doi": "10.3389/fphar.2021.598925", "pmid": "33716737", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "598925"}, {"db": "pmc", "key": "PMC7952300"}], "notes": [], "created": "2021-03-17T07:46:57.745Z", "modified": "2021-03-22T11:40:39.483Z"}, {"entity": "publication", "iuid": "42cbde64f28a462e8b59f47ad4eebf6d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/42cbde64f28a462e8b59f47ad4eebf6d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/42cbde64f28a462e8b59f47ad4eebf6d"}}, "title": "Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19: A Systematic Review and Meta-analysis.", "authors": [{"family": "Janiaud", "given": "Perrine", "initials": "P"}, {"family": "Axfors", "given": "Cathrine", "initials": "C"}, {"family": "Schmitt", "given": "Andreas M", "initials": "AM"}, {"family": "Gloy", "given": "Viktoria", "initials": "V"}, {"family": "Ebrahimi", "given": "Fahim", "initials": "F"}, {"family": "Hepprich", "given": "Matthias", "initials": "M"}, {"family": "Smith", "given": "Emily R", "initials": "ER"}, {"family": "Haber", "given": "Noah A", "initials": "NA"}, {"family": "Khanna", "given": "Nina", "initials": "N"}, {"family": "Moher", "given": "David", "initials": "D"}, {"family": "Goodman", "given": "Steven N", "initials": "SN"}, {"family": "Ioannidis", "given": "John P A", "initials": "JPA"}, {"family": "Hemkens", "given": "Lars G", "initials": "LG"}], "type": "journal article", "published": "2021-02-26", "journal": {"title": "JAMA", "issn": "1538-3598", "volume": null, "issue": null, "issn-l": "0098-7484"}, "abstract": "Convalescent plasma is a proposed treatment for COVID-19.\n\nTo assess clinical outcomes with convalescent plasma treatment vs placebo or standard of care in peer-reviewed and preprint publications or press releases of randomized clinical trials (RCTs).\n\nPubMed, the Cochrane COVID-19 trial registry, and the Living Overview of Evidence platform were searched until January 29, 2021.\n\nThe RCTs selected compared any type of convalescent plasma vs placebo or standard of care for patients with confirmed or suspected COVID-19 in any treatment setting.\n\nTwo reviewers independently extracted data on relevant clinical outcomes, trial characteristics, and patient characteristics and used the Cochrane Risk of Bias Assessment Tool. The primary analysis included peer-reviewed publications of RCTs only, whereas the secondary analysis included all publicly available RCT data (peer-reviewed publications, preprints, and press releases). Inverse variance-weighted meta-analyses were conducted to summarize the treatment effects. The certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation.\n\nAll-cause mortality, length of hospital stay, clinical improvement, clinical deterioration, mechanical ventilation use, and serious adverse events.\n\nA total of 1060 patients from 4 peer-reviewed RCTs and 10 722 patients from 6 other publicly available RCTs were included. The summary risk ratio (RR) for all-cause mortality with convalescent plasma in the 4 peer-reviewed RCTs was 0.93 (95% CI, 0.63 to 1.38), the absolute risk difference was -1.21% (95% CI, -5.29% to 2.88%), and there was low certainty of the evidence due to imprecision. Across all 10 RCTs, the summary RR was 1.02 (95% CI, 0.92 to 1.12) and there was moderate certainty of the evidence due to inclusion of unpublished data. Among the peer-reviewed RCTs, the summary hazard ratio was 1.17 (95% CI, 0.07 to 20.34) for length of hospital stay, the summary RR was 0.76 (95% CI, 0.20 to 2.87) for mechanical ventilation use (the absolute risk difference for mechanical ventilation use was -2.56% [95% CI, -13.16% to 8.05%]), and there was low certainty of the evidence due to imprecision for both outcomes. Limited data on clinical improvement, clinical deterioration, and serious adverse events showed no significant differences.\n\nTreatment with convalescent plasma compared with placebo or standard of care was not significantly associated with a decrease in all-cause mortality or with any benefit for other clinical outcomes. The certainty of the evidence was low to moderate for all-cause mortality and low for other outcomes.", "doi": "10.1001/jama.2021.2747", "pmid": "33635310", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "2777060"}], "notes": [], "created": "2021-03-01T10:31:35.067Z", "modified": "2021-03-01T10:31:35.077Z"}, {"entity": "publication", "iuid": "385673f5df3646bd8e3b61eeec8fda40", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/385673f5df3646bd8e3b61eeec8fda40.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/385673f5df3646bd8e3b61eeec8fda40"}}, "title": "Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19.", "authors": [{"family": "Gupta", "given": "Aakriti", "initials": "A"}, {"family": "Madhavan", "given": "Mahesh V", "initials": "MV"}, {"family": "Poterucha", "given": "Timothy J", "initials": "TJ"}, {"family": "DeFilippis", "given": "Ersilia M", "initials": "EM"}, {"family": "Hennessey", "given": "Jessica A", "initials": "JA"}, {"family": "Redfors", "given": "Bjorn", "initials": "B"}, {"family": "Eckhardt", "given": "Christina", "initials": "C"}, {"family": "Bikdeli", "given": "Behnood", "initials": "B"}, {"family": "Platt", "given": "Jonathan", "initials": "J"}, {"family": "Nalbandian", "given": "Ani", "initials": "A"}, {"family": "Elias", "given": "Pierre", "initials": "P"}, {"family": "Cummings", "given": "Matthew J", "initials": "MJ"}, {"family": "Nouri", "given": "Shayan N", "initials": "SN"}, {"family": "Lawlor", "given": "Matthew", "initials": "M"}, {"family": "Ranard", "given": "Lauren S", "initials": "LS"}, {"family": "Li", "given": "Jianhua", "initials": "J"}, {"family": "Boyle", "given": "Claudia", "initials": "C"}, {"family": "Givens", "given": "Raymond", "initials": "R"}, {"family": "Brodie", "given": "Daniel", "initials": "D"}, {"family": "Krumholz", "given": "Harlan M", "initials": "HM"}, {"family": "Stone", "given": "Gregg W", "initials": "GW"}, {"family": "Sethi", "given": "Sanjum S", "initials": "SS"}, {"family": "Burkhoff", "given": "Daniel", "initials": "D"}, {"family": "Uriel", "given": "Nir", "initials": "N"}, {"family": "Schwartz", "given": "Allan", "initials": "A"}, {"family": "Leon", "given": "Martin B", "initials": "MB"}, {"family": "Kirtane", "given": "Ajay J", "initials": "AJ"}, {"family": "Wan", "given": "Elaine Y", "initials": "EY"}, {"family": "Parikh", "given": "Sahil A", "initials": "SA"}], "type": "journal article", "published": "2021-02-26", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "1325", "issn-l": "2041-1723"}, "abstract": "The coronavirus disease 2019 (COVID-19) can result in a hyperinflammatory state, leading to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic complications, among other sequelae. Statins, which are known to have anti-inflammatory and antithrombotic properties, have been studied in the setting of other viral infections, but their benefit has not been assessed in COVID-19. This is a retrospective analysis of patients admitted with COVID-19 from February 1 st through May 12th, 2020 with study period ending on June 11th, 2020. Antecedent statin use was assessed using medication information available in the electronic medical record. We constructed a multivariable logistic regression model to predict the propensity of receiving statins, adjusting for baseline sociodemographic and clinical characteristics, and outpatient medications. The primary endpoint includes in-hospital mortality within 30 days. A total of 2626 patients were admitted during the study period, of whom 951 (36.2%) were antecedent statin users. Among 1296 patients (648 statin users, 648 non-statin users) identified with 1:1 propensity-score matching, statin use is significantly associated with lower odds of the primary endpoint in the propensity-matched cohort (OR 0.47, 95% CI 0.36-0.62, p < 0.001). We conclude that antecedent statin use in patients hospitalized with COVID-19 is associated with lower inpatient mortality.", "doi": "10.1038/s41467-021-21553-1", "pmid": "33637713", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-21553-1"}], "notes": [], "created": "2021-03-01T10:27:41.788Z", "modified": "2021-03-01T10:27:41.799Z"}, {"entity": "publication", "iuid": "83652c6eab6545dc856b7f96cab7fcbb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/83652c6eab6545dc856b7f96cab7fcbb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/83652c6eab6545dc856b7f96cab7fcbb"}}, "title": "A COVID-19 pandemic-specific, structured care process for Peritoneal Dialysis patients facilitated by Telemedicine: therapy continuity, prevention and complications management.", "authors": [{"family": "Polanco", "given": "Elianny", "initials": "E"}, {"family": "Aquey", "given": "Mercedes", "initials": "M"}, {"family": "Collado", "given": "Jhanna", "initials": "J"}, {"family": "Campos", "given": "Erwin", "initials": "E"}, {"family": "Guzman", "given": "Janny", "initials": "J"}, {"family": "Cuevas-Budhart", "given": "Miguel Angel", "initials": "MA"}, {"family": "Divino-Filho", "given": "Jos\u00e9 Carolino", "initials": "JC"}, {"family": "Ramos-Sanchez", "given": "Alfonso", "initials": "A"}], "type": "journal article", "published": "2021-02-26", "journal": {"title": "Ther Apher Dial", "issn": "1744-9987", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Coronavirus 2019 disease (COVID-19) has been declared a pandemia. Peritoneal dialysis (PD), being a home therapy, allows for physical distancing measures and movement restrictions. In order to prevent COVID-19 contagious among the Dominican Republic National Health System PD program patients, a follow up virtual protocol for this group was developed. The aim of this study is to outline the protocol established by the PD program's healthcare team using Telemedicine in order to avoid COVID-19 contagious and to report initial results and outcomes of this initiative.\r\n\r\nThis is an observational prospective longitudinal study with 946 patients being treated in seven centers distributed throughout the country between April 1 st and June 30th. The protocol was implemented focusing on the patient follow-up; risk mitigation data were registered and collected from electronic records.\r\n\r\nDuring the follow-up period, 95 catheters were implanted, 64 patients-initiated PD and the remaining were in training. A total of 9 532 consultations were given by the different team specialists, being 8 720 (91%) virtual and 812 (9%) face -to -face consultations. The transfer rate to HD was 0.29% whereas the peritonitis rate was 0.11 episode per patient/year. Eighteen adults tested positive for COVID-19.\r\n\r\nThe implementation of the protocol and Telemedicine utilization have ensured follow-up and monitoring, preserved therapy, controlled complications and PD lives protected. This article is protected by copyright. All rights reserved.", "doi": "10.1111/1744-9987.13635", "pmid": "33634948", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-03-01T10:32:43.595Z", "modified": "2021-06-18T14:28:10.323Z"}, {"entity": "publication", "iuid": "51fccdcf6a9d42be97470f6cd75694fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/51fccdcf6a9d42be97470f6cd75694fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/51fccdcf6a9d42be97470f6cd75694fc"}}, "title": "The fear of the COVID-19 Scale: validation in the Portuguese general population.", "authors": [{"family": "Soares", "given": "Francisca Ribeiro", "initials": "FR"}, {"family": "Afonso", "given": "Rosa Marina", "initials": "RM"}, {"family": "Martins", "given": "Ana Paula", "initials": "AP"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Rosa", "given": "Celina Pires", "initials": "CP"}], "type": "journal article", "published": "2021-02-25", "journal": {"title": "Death Stud", "issn": "1091-7683", "volume": null, "issue": null, "pages": "1-7", "issn-l": null}, "abstract": "The coronavirus disease (COVID-19) pandemic is having a profound effect on mental health and it is therefore fundamental to evaluate individual psychological responses to COVID-19. The 7-item Fear of COVID-19 Scale (FCV-19S) assesses different aspects of the fear of coronavirus and has been applied worldwide. This study aimed to translate and validate the FCV-19S in the Portuguese population. The scale was administered to a convenience sample of 1203 Portuguese adults. Exploratory factor analysis was carried out on the initial model proposed by the authors of the FCV-19S. Further analysis revealed that the Portuguese version has good psychometric properties.", "doi": "10.1080/07481187.2021.1889722", "pmid": "33630728", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-03-01T10:22:11.159Z", "modified": "2021-03-01T10:22:11.182Z"}, {"entity": "publication", "iuid": "0de3e14051a2404e9d8a3d49b564064c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0de3e14051a2404e9d8a3d49b564064c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0de3e14051a2404e9d8a3d49b564064c"}}, "title": "Long-term outcome after intensive care for COVID-19: differences between men and women-a nationwide cohort study.", "authors": [{"family": "Zettersten", "given": "Erik", "initials": "E"}, {"family": "Engerstr\u00f6m", "given": "Lars", "initials": "L"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "J\u00e4derling", "given": "Gabriella", "initials": "G"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}, {"family": "Block", "given": "Linda", "initials": "L"}, {"family": "Larsson", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2021-02-25", "journal": {"title": "Crit Care", "issn": "1466-609X", "volume": "25", "issue": "1", "pages": "86", "issn-l": "1364-8535"}, "abstract": "Questions remain about long-term outcome for COVID-19 patients in general, and differences between men and women in particular given the fact that men seem to suffer a more dramatic course of the disease. We therefore analysed outcome beyond 90 days in ICU patients with COVID-19, with special focus on differences between men and women.\n\nWe identified all patient \u2265 18 years with COVID-19 admitted between March 6 and June 30, 2020, in the Swedish Intensive Care Registry. Patients were followed until death or study end-point October 22, 2020. Association with patient sex and mortality, in addition to clinical variables, was estimated using Cox regression. We also performed a logistic regression model estimating factors associated with 90-day mortality.\n\nIn total, 2354 patients with COVID-19 were included. Four patients were still in the ICU at study end-point. Median follow-up time was 183 days. Mortality at 90-days was 26.9%, 23.4% in women and 28.2% in men. After 90 days until end of follow-up, only 11 deaths occurred. On multivariable Cox regression analysis, male sex (HR 1.28, 95% CI 1.06-1.54) remained significantly associated with mortality even after adjustments. Additionally, age, COPD/asthma, immune deficiency, malignancy, SAPS3 and admission month were associated with mortality. The logistic regression model of 90-day mortality showed almost identical results.\n\nIn this nationwide study of ICU patients with COVID-19, men were at higher risk of poor long-term outcome compared to their female counterparts. The underlying mechanisms for these differences are not fully understood and warrant further studies.", "doi": "10.1186/s13054-021-03511-x", "pmid": "33632273", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-021-03511-x"}, {"db": "pmc", "key": "PMC7906087"}], "notes": [], "created": "2021-03-09T06:31:12.788Z", "modified": "2021-03-09T06:33:30.216Z"}, {"entity": "publication", "iuid": "2850b672e81a4a34a39690a4cf8de736", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2850b672e81a4a34a39690a4cf8de736.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2850b672e81a4a34a39690a4cf8de736"}}, "title": "Genetic predisposition to psychiatric disorders and risk of COVID-19", "authors": [{"family": "Chen", "given": "Wenwen", "initials": "W"}, {"family": "Zeng", "given": "Yu", "initials": "Y"}, {"family": "Suo", "given": "Chen", "initials": "C"}, {"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Chen", "given": "Yilong", "initials": "Y"}, {"family": "Hou", "given": "Can", "initials": "C"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "Sun", "given": "Yajing", "initials": "Y"}, {"family": "Qu", "given": "Yuanyuan", "initials": "Y"}, {"family": "Lu", "given": "Donghao", "initials": "D"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "posted-content", "published": "2021-02-25", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.23.21251866", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-03-25T14:07:18.181Z", "modified": "2021-05-17T19:30:55.631Z"}, {"entity": "publication", "iuid": "0fab6b563c944cb3bc40603c2e02acad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0fab6b563c944cb3bc40603c2e02acad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0fab6b563c944cb3bc40603c2e02acad"}}, "title": "Beyond Chronological Age: Frailty and Multimorbidity Predict In-Hospital Mortality in Patients With Coronavirus Disease 2019.", "authors": [{"family": "Marengoni", "given": "Alessandra", "initials": "A"}, {"family": "Zucchelli", "given": "Alberto", "initials": "A", "orcid": "0000-0001-5992-8506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5ad05bd796f49c983931341109b1578.json"}}, {"family": "Vetrano", "given": "Davide Liborio", "initials": "DL", "orcid": "0000-0002-3099-4830", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0124721bb214413a34c965b6accc64b.json"}}, {"family": "Armellini", "given": "Andrea", "initials": "A"}, {"family": "Botteri", "given": "Emanuele", "initials": "E"}, {"family": "Nicosia", "given": "Franco", "initials": "F"}, {"family": "Romanelli", "given": "Giuseppe", "initials": "G"}, {"family": "Beindorf", "given": "Eva Andrea", "initials": "EA"}, {"family": "Giansiracusa", "given": "Paola", "initials": "P"}, {"family": "Garrafa", "given": "Emirena", "initials": "E"}, {"family": "Ferrucci", "given": "Luigi", "initials": "L", "orcid": "0000-0002-6273-1613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2edec69f580a4daea9ee99fa666c8f53.json"}}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Bernabei", "given": "Roberto", "initials": "R"}, {"family": "Onder", "given": "Graziano", "initials": "G"}], "type": "journal article", "published": "2021-02-25", "journal": {"title": "J Gerontol A Biol Sci Med Sci", "issn": "1758-535X", "issn-l": "1079-5006", "volume": "76", "issue": "3", "pages": "e38-e45"}, "abstract": "We evaluated whether frailty and multimorbidity predict in-hospital mortality in patients with COVID-19 beyond chronological age.\n\nA total of 165 patients admitted from March 8th to April 17th, 2020, with COVID-19 in an acute geriatric ward in Italy were included. Predisease frailty was assessed with the Clinical Frailty Scale (CFS). Multimorbidity was defined as the co-occurrence of \u22652 diseases in the same patient. The hazard ratio (HR) of in-hospital mortality as a function of CFS score and number of chronic diseases in the whole population and in those aged 70+ years were calculated.\n\nAmong the 165 patients, 112 were discharged, 11 were transferred to intensive care units, and 42 died. Patients who died were older (81.0 vs 65.2 years, p < .001), more frequently multimorbid (97.6 vs 52.8%; p < .001), and more likely frail (37.5 vs 4.1%; p < .001). Less than 2.0% of patients without multimorbidity and frailty, 28% of those with multimorbidity only, and 75% of those with both multimorbidity and frailty died. Each unitary increment in the CFS was associated with a higher risk of in-hospital death in the whole sample (HR = 1.3; 95% CI = 1.05-1.62) and in patients aged 70+ years (HR = 1.29; 95% CI = 1.04-1.62), whereas the number of chronic diseases was not significantly associated with higher risk of death. The CFS addition to age and sex increased mortality prediction by 9.4% in those aged 70+ years.\n\nFrailty identifies patients with COVID-19 at risk of in-hospital death independently of age. Multimorbidity contributes to prognosis because of the very low probability of death in its absence.", "doi": "10.1093/gerona/glaa291", "pmid": "33216846", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7717138"}, {"db": "pii", "key": "5996087"}], "notes": [], "created": "2020-11-26T14:33:41.983Z", "modified": "2023-06-19T15:29:21.072Z"}, {"entity": "publication", "iuid": "9c0721ae5def464c81523f9e3565392e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9c0721ae5def464c81523f9e3565392e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9c0721ae5def464c81523f9e3565392e"}}, "title": "A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.", "authors": [{"family": "Zhou", "given": "Sirui", "initials": "S"}, {"family": "Butler-Laporte", "given": "Guillaume", "initials": "G"}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T"}, {"family": "Morrison", "given": "David R", "initials": "DR"}, {"family": "Afilalo", "given": "Jonathan", "initials": "J"}, {"family": "Afilalo", "given": "Marc", "initials": "M"}, {"family": "Laurent", "given": "Laetitia", "initials": "L"}, {"family": "Pietzner", "given": "Maik", "initials": "M"}, {"family": "Kerrison", "given": "Nicola", "initials": "N"}, {"family": "Zhao", "given": "Kaiqiong", "initials": "K"}, {"family": "Brunet-Ratnasingham", "given": "Elsa", "initials": "E"}, {"family": "Henry", "given": "Danielle", "initials": "D"}, {"family": "Kimchi", "given": "Nofar", "initials": "N"}, {"family": "Afrasiabi", "given": "Zaman", "initials": "Z"}, {"family": "Rezk", "given": "Nardin", "initials": "N"}, {"family": "Bouab", "given": "Meriem", "initials": "M"}, {"family": "Petitjean", "given": "Louis", "initials": "L"}, {"family": "Guzman", "given": "Charlotte", "initials": "C"}, {"family": "Xue", "given": "Xiaoqing", "initials": "X"}, {"family": "Tselios", "given": "Chris", "initials": "C"}, {"family": "Vulesevic", "given": "Branka", "initials": "B"}, {"family": "Adeleye", "given": "Olumide", "initials": "O"}, {"family": "Abdullah", "given": "Tala", "initials": "T"}, {"family": "Almamlouk", "given": "Noor", "initials": "N"}, {"family": "Chen", "given": "Yiheng", "initials": "Y"}, {"family": "Chass\u00e9", "given": "Micha\u00ebl", "initials": "M"}, {"family": "Durand", "given": "Madeleine", "initials": "M"}, {"family": "Paterson", "given": "Clare", "initials": "C"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Greenwood", "given": "Celia M T", "initials": "CMT"}, {"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "Langenberg", "given": "Claudia", "initials": "C"}, {"family": "Thysell", "given": "Elin", "initials": "E"}, {"family": "Pollak", "given": "Michael", "initials": "M"}, {"family": "Mooser", "given": "Vincent", "initials": "V"}, {"family": "Forgetta", "given": "Vincenzo", "initials": "V"}, {"family": "Kaufmann", "given": "Daniel E", "initials": "DE"}, {"family": "Richards", "given": "J Brent", "initials": "JB"}], "type": "journal article", "published": "2021-02-25", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956", "volume": "27", "issue": "4", "pages": "659-667"}, "abstract": "To identify circulating proteins influencing Coronavirus Disease 2019 (COVID-19) susceptibility and severity, we undertook a two-sample Mendelian randomization (MR) study, rapidly scanning hundreds of circulating proteins while reducing bias due to reverse causation and confounding. In up to 14,134 cases and 1.2 million controls, we found that an s.d. increase in OAS1 levels was associated with reduced COVID-19 death or ventilation (odds ratio (OR) = 0.54, P = 7 \u00d7 10 -8), hospitalization (OR = 0.61, P = 8 \u00d7 10-8) and susceptibility (OR = 0.78, P = 8 \u00d7 10-6). Measuring OAS1 levels in 504 individuals, we found that higher plasma OAS1 levels in a non-infectious state were associated with reduced COVID-19 susceptibility and severity. Further analyses suggested that a Neanderthal isoform of OAS1 in individuals of European ancestry affords this protection. Thus, evidence from MR and a case-control study support a protective role for OAS1 in COVID-19 adverse outcomes. Available pharmacological agents that increase OAS1 levels could be prioritized for drug development.", "doi": "10.1038/s41591-021-01281-1", "pmid": "33633408", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-021-01281-1"}], "notes": [], "created": "2021-03-01T10:33:22.847Z", "modified": "2021-05-27T16:07:53.701Z"}, {"entity": "publication", "iuid": "27dbd4e1c95d41ada0ae228dda5eda93", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27dbd4e1c95d41ada0ae228dda5eda93.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27dbd4e1c95d41ada0ae228dda5eda93"}}, "title": "Ophthalmic Screening in Patients with Coronavirus Disease 2019: A Prospective Cohort Study.", "authors": [{"family": "Papazoglou", "given": "Anthia", "initials": "A"}, {"family": "Conen", "given": "Anna", "initials": "A"}, {"family": "Haubitz", "given": "Sebastian", "initials": "S"}, {"family": "Tschopp", "given": "Markus", "initials": "M"}, {"family": "Guignard", "given": "Viviane J", "initials": "VJ"}, {"family": "Menke", "given": "Marcel N", "initials": "MN"}, {"family": "Enz", "given": "Tim J", "initials": "TJ"}], "type": "journal article", "published": "2021-02-24", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "10", "issue": "5", "pages": null}, "abstract": "Postmortem pathological examinations, animal studies, and anecdotal reports suggest that coronavirus disease 2019 (COVID-19) could potentially affect intraocular tissue. However, published evidence is scarce and conflicting. In our study, we screened 100 eyes of 50 patients hospitalized for COVID-19. Relevant medical and ophthalmological history was assessed as well as symptoms, laboratory results, specific treatments, clinical course, and outcome. Ophthalmic exams including assessment of best corrected visual acuity (BCVA), intraocular pressure (IOP), color perception, ocular motility, ophthalmoscopy as well as optical coherence tomography (OCT) of the macula and the optic disc was performed at hospital admission and 29 to 192 days later. Of the 50 patients included, 14 (28%) were female. Median age was 64.5 (range 29-90) years. COVID-19 severity was mild in 15 (30%), severe in 30 (60%), and critical in five cases (10%). At baseline, median BCVA was 0.1 (0-1.8) Logarithm of the Minimum Angle of Resolution (LogMAR) and median IOP was 16 (8-22) mmHg. At follow-up, no relevant changes in BCVA and IOP were documented. No signs of active intraocular inflammation or optic nerve affection were found and OCT findings were widely stable during the observation period. Our findings suggest that COVID-19 does not regularly affect intraocular tissue.", "doi": "10.3390/jcm10050896", "pmid": "33668256", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "jcm10050896"}, {"db": "URL", "key": "https://www.mdpi.com/2077-0383/10/5/896/s1", "description": "Patient characteristics, medical treatment regiments, symptoms, laboratory findings, ophthalmic findings, systemic symtoms for each patient"}], "notes": [], "created": "2021-03-08T05:28:12.245Z", "modified": "2021-06-18T12:52:19.368Z"}, {"entity": "publication", "iuid": "f3681b42d7da4392816918aab5db8ce7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f3681b42d7da4392816918aab5db8ce7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f3681b42d7da4392816918aab5db8ce7"}}, "title": "Multisystem inflammatory syndrome in children and adults (MIS-C/A): Case definition & guidelines for data collection, analysis, and presentation of immunization safety data.", "authors": [{"family": "Vogel", "given": "Tiphanie P", "initials": "TP"}, {"family": "Top", "given": "Karina A", "initials": "KA"}, {"family": "Karatzios", "given": "Christos", "initials": "C"}, {"family": "Hilmers", "given": "David C", "initials": "DC"}, {"family": "Tapia", "given": "Lorena I", "initials": "LI"}, {"family": "Moceri", "given": "Pamela", "initials": "P"}, {"family": "Giovannini-Chami", "given": "Lisa", "initials": "L"}, {"family": "Wood", "given": "Nicholas", "initials": "N"}, {"family": "Chandler", "given": "Rebecca E", "initials": "RE"}, {"family": "Klein", "given": "Nicola P", "initials": "NP"}, {"family": "Schlaudecker", "given": "Elizabeth P", "initials": "EP"}, {"family": "Poli", "given": "M Cecilia", "initials": "MC"}, {"family": "Muscal", "given": "Eyal", "initials": "E"}, {"family": "Munoz", "given": "Flor M", "initials": "FM"}], "type": "journal article", "published": "2021-02-24", "journal": {"title": "Vaccine", "issn": "1873-2518", "volume": null, "issue": null, "issn-l": null}, "abstract": "This is a Brighton Collaboration Case Definition of the term \"Multisystem Inflammatory Syndrome in Children and Adults (MIS-C/A)\" to be utilized in the evaluation of adverse events following immunization. The case definition was developed by topic experts convened by the Coalition for Epidemic Preparedness Innovations (CEPI) in the context of active development of vaccines for SARS-CoV-2. The format of the Brighton Collaboration was followed, including an exhaustive review of the literature, to develop a consensus definition and defined levels of certainty. The document underwent peer review by the Brighton Collaboration Network and by selected expert external reviewers prior to submission. The comments of the reviewers were taken into consideration and edits incorporated into this final manuscript.", "doi": "10.1016/j.vaccine.2021.01.054", "pmid": "33640145", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(21)00093-1"}], "notes": [], "created": "2021-03-01T10:25:43.038Z", "modified": "2021-03-01T10:25:43.048Z"}, {"entity": "publication", "iuid": "66da60a87f714d26af9d07d6218d0f85", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66da60a87f714d26af9d07d6218d0f85.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66da60a87f714d26af9d07d6218d0f85"}}, "title": "Impact of winter holiday and government responses on mortality in Europe during the first wave of the COVID-19 pandemic.", "authors": [{"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}, {"family": "Mattisson", "given": "Kristoffer", "initials": "K"}, {"family": "Ahlbom", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-02-24", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": null, "issue": null, "pages": null}, "abstract": "This aggregated population study investigated the impact of the seemingly quasi-randomly assigned school winter holiday in week 6-10 (February to early March) on excess mortality in 219 European regions (11 countries) during the COVID-19 pandemic in the spring 2020. A secondary aim was to evaluate the impact of government responses to the early inflow of infected cases.\r\n\r\nData on government responses week 8-14 were obtained from the Oxford COVID-19 Government Response Tracker. Regional data on total all-cause mortality during week 14-23 in 2020 were retrieved from Eurostat and national statistical agencies and compared with the average mortality during same period 2015-2019. Variance-weighted least square regression was used with mortality difference as dependent variable with adjustment for country, population density and age distribution.\r\n\r\nBeing a region with winter holiday exclusively in week 9 was in the adjusted analysis associated with 16 weekly excess deaths (95% confidence interval 13 to 20) per million inhabitants during week 14-23, which corresponds to 38% of the excess mortality in these regions. A more stringent response implemented in week 11, corresponding to 10 additional units on the 0-100 ordinal scale, was associated with 20 fewer weekly deaths (95% confidence interval 18 to 22) per million inhabitants.\r\n\r\nWinter holiday in week 9 was an amplifying event that contributed importantly to the excess mortality observed in the study regions during the spring 2020. Timely government responses to the resulting early inflow of cases reduced the excess in mortality.", "doi": "10.1093/eurpub/ckab017", "pmid": "33624821", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6149087"}], "notes": [], "created": "2021-02-25T10:12:25.738Z", "modified": "2021-06-18T14:24:11.844Z"}, {"entity": "publication", "iuid": "24a65e888eac4b9e8306546e341d401c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24a65e888eac4b9e8306546e341d401c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24a65e888eac4b9e8306546e341d401c"}}, "title": "COVID-19 drug practices risk antimicrobial resistance evolution.", "authors": [{"family": "Afshinnekoo", "given": "Ebrahim", "initials": "E"}, {"family": "Bhattacharya", "given": "Chandrima", "initials": "C"}, {"family": "Burguete-Garc\u00eda", "given": "Ana", "initials": "A"}, {"family": "Castro-Nallar", "given": "Eduardo", "initials": "E"}, {"family": "Deng", "given": "Youping", "initials": "Y"}, {"family": "Desnues", "given": "Christelle", "initials": "C"}, {"family": "Dias-Neto", "given": "Emmanuel", "initials": "E"}, {"family": "Elhaik", "given": "Eran", "initials": "E"}, {"family": "Iraola", "given": "Gregorio", "initials": "G"}, {"family": "Jang", "given": "Soojin", "initials": "S"}, {"family": "\u0141abaj", "given": "Pawe\u0142 P", "initials": "PP"}, {"family": "Mason", "given": "Christopher E", "initials": "CE"}, {"family": "Nagarajan", "given": "Niranjan", "initials": "N"}, {"family": "Poulsen", "given": "Michael", "initials": "M"}, {"family": "Prithiviraj", "given": "Bharath", "initials": "B"}, {"family": "Siam", "given": "Rania", "initials": "R"}, {"family": "Shi", "given": "Tieliu", "initials": "T"}, {"family": "Suzuki", "given": "Haruo", "initials": "H"}, {"family": "Werner", "given": "Johannes", "initials": "J"}, {"family": "Zambrano", "given": "Maria Mercedes", "initials": "MM"}, {"family": "Bhattacharyya", "given": "Malay", "initials": "M"}, {"family": "MetaSUB Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2021-02-24", "journal": {"title": "The Lancet Microbe", "issn": "2666-5247", "volume": null, "issue": null, "issn-l": "2666-5247"}, "abstract": null, "doi": "10.1016/S2666-5247(21)00039-2", "pmid": "33655229", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2666-5247(21)00039-2"}, {"db": "pmc", "key": "PMC7906697"}], "notes": [], "created": "2021-03-04T15:02:32.660Z", "modified": "2021-03-04T15:03:01.727Z"}, {"entity": "publication", "iuid": "70eb4ec5d8b546539a46419b7a79a095", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70eb4ec5d8b546539a46419b7a79a095.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70eb4ec5d8b546539a46419b7a79a095"}}, "title": "Mental health among elite athletes in Norway during a selected period of the COVID-19 pandemic.", "authors": [{"family": "Pensgaard", "given": "Anne Marte", "initials": "AM", "orcid": "0000-0003-4690-9888", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec779958709e4ca18ff8fdf000d55075.json"}}, {"family": "Oevreboe", "given": "Tom Henning", "initials": "TH", "orcid": "0000-0003-4965-1018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee49f62a86ee4e97a5cc820570933f27.json"}}, {"family": "Ivarsson", "given": "Andreas", "initials": "A", "orcid": "0000-0002-8987-5975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e77e48568e184548a5da063cb6b339be.json"}}], "type": "journal article", "published": "2021-02-23", "journal": {"title": "BMJ Open Sport Exerc Med", "issn": "2055-7647", "volume": "7", "issue": "1", "pages": "e001025", "issn-l": null}, "abstract": "To investigate the prevalence of mental health problems and satisfaction with life among different groups of elite athletes during a selected period of the COVID-19 pandemic and examine how COVID-19 related consequences were associated with these variables.\n\nCross-sectional data collection during a selected period of the COVID-19 pandemic in Norway.\n\n378 elite athletes, mean age 26.86 (range 18-59), 159 females and 219 males, divided into Olympic-level and Paralympic-level athletes (n=194) and elite and semielite athletes (n=184).\n\nHopkins Symptoms Check List - 10; symptoms of anxiety and depression; Bergen Insomnia Scale; Eating Disorder Examination Questionnaire Short; Canadian Problem Gambling Index and Satisfaction with Life Scale. In addition, we included specific COVID-19 questions (eg, financial concern, keeping daily routines, perceived coping and motivation).\n\nSymptoms of insomnia (38.3%) and depression (22.3%) were most prevalent within the sample. Symptoms of eating disorders more prevalent among female athletes (8.8% vs 1.4%) while symptoms of gambling problems were higher among male athletes (8.6% vs 1.3%). Olympic and Paralympic athletes reported lower levels of anxiety and depression symptoms than elite and semielite athletes. Financial concerns were associated with an increased risk of mental health problems, while daily routines and perception of coping were associated with less mental health problems and higher satisfaction with life.\n\nSymptoms of insomnia and depression were the two most common mental health problems reported during this selected phase of the COVID-19 pandemic. Elite and semielite athletes reported financial concerns as a risk factor for mental health problems at a larger degree than Olympic and Paralympic athletes.", "doi": "10.1136/bmjsem-2020-001025", "pmid": "34192011", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjsem-2020-001025"}, {"db": "pmc", "key": "PMC7907612"}], "notes": [], "created": "2021-07-05T14:26:16.214Z", "modified": "2021-07-05T15:08:54.718Z"}, {"entity": "publication", "iuid": "90f48cf5d5dd4a08b86cc84031aec1c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90f48cf5d5dd4a08b86cc84031aec1c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90f48cf5d5dd4a08b86cc84031aec1c9"}}, "title": "Impact of the COVID-19 pandemic on morbidity and mortality in patients with inflammatory joint diseases and in the general population: a nationwide Swedish cohort study.", "authors": [{"family": "Bower", "given": "Hannah", "initials": "H"}, {"family": "Frisell", "given": "Thomas", "initials": "T"}, {"family": "Di Giuseppe", "given": "Daniela", "initials": "D"}, {"family": "Delcoigne", "given": "B\u00e9n\u00e9dicte", "initials": "B"}, {"family": "Ahlenius", "given": "Gerd-Marie", "initials": "G"}, {"family": "Baecklund", "given": "Eva", "initials": "E"}, {"family": "Chatzidionysiou", "given": "Katerina", "initials": "K"}, {"family": "Feltelius", "given": "Nils", "initials": "N"}, {"family": "Forsblad-d'Elia", "given": "Helena", "initials": "H"}, {"family": "Kastbom", "given": "Alf", "initials": "A"}, {"family": "Klareskog", "given": "Lars", "initials": "L"}, {"family": "Lindqvist", "given": "Elisabet", "initials": "E"}, {"family": "Lindstr\u00f6m", "given": "Ulf", "initials": "U"}, {"family": "Turesson", "given": "Carl", "initials": "C"}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C"}, {"family": "Askling", "given": "Johan", "initials": "J"}, {"family": "ARTIS Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-02-23", "journal": {"title": "Ann Rheum Dis", "issn": "1468-2060", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To estimate absolute and relative risks for all-cause mortality and for severe COVID-19 in inflammatory joint diseases (IJDs) and with antirheumatic therapies.\r\n\r\nThrough Swedish nationwide multiregister linkages, we selected all adult patients with rheumatoid arthritis (RA, n=53 455 in March 2020), other IJDs (here: spondyloarthropathies, psoriatic arthritis and juvenile idiopathic arthritis, n=57 112), their antirheumatic drug use, and individually matched population referents. We compared annual all-cause mortality March-September 2015 through 2020 within and across cohorts, and assessed absolute and relative risks for hospitalisation, admission to intensive care and death due to COVID-19 March-September 2020, using Cox regression.\r\n\r\nDuring March-September 2020, the absolute all-cause mortality in RA and in other IJDs was higher than 2015-2019, but relative risks versus the general population (around 2 and 1.5) remained similar during 2020 compared with 2015-2019. Among patients with IJD, the risks of hospitalisation (0.5% vs 0.3% in their population referents), admission to intensive care (0.04% vs 0.03%) and death (0.10% vs 0.07%) due to COVID-19 were low. Antirheumatic drugs were not associated with increased risk of serious COVID-19 outcomes, although for certain drugs, precision was limited.\r\n\r\nRisks of severe COVID-19-related outcomes were increased among patients with IJDs, but risk increases were also seen for non-COVID-19 morbidity. Overall absolute and excess risks are low and the level of risk increases are largely proportionate to those in the general population, and explained by comorbidities. With possible exceptions, antirheumatic drugs do not have a major impact on these risks.", "doi": "10.1136/annrheumdis-2021-219845", "pmid": "33622688", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "annrheumdis-2021-219845"}], "notes": [], "created": "2021-02-25T12:30:45.045Z", "modified": "2021-06-18T14:23:09.973Z"}, {"entity": "publication", "iuid": "1587f1507ee34fd9ba0ae982cdb57e9a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1587f1507ee34fd9ba0ae982cdb57e9a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1587f1507ee34fd9ba0ae982cdb57e9a"}}, "title": "Critical COVID-19 represents an endothelial disease with high similarity to kidney disease on the molecular level", "authors": [{"family": "Siwy", "given": "Justyna", "initials": "J"}, {"family": "Wendt", "given": "Ralph", "initials": "R"}, {"family": "Albalat", "given": "Amaya", "initials": "A"}, {"family": "He", "given": "Tianlin", "initials": "T"}, {"family": "Mischak", "given": "Harald", "initials": "H"}, {"family": "Mullen", "given": "William", "initials": "W"}, {"family": "Latosinska", "given": "Agnieszka", "initials": "A"}, {"family": "Luebbert", "given": "Christoph", "initials": "C"}, {"family": "Kalbitz", "given": "Sven", "initials": "S"}, {"family": "Mebazaa", "given": "Alexandre", "initials": "A"}, {"family": "Peters", "given": "Bjoern", "initials": "B"}, {"family": "Stegmayr", "given": "Bernd", "initials": "B"}, {"family": "Spasovski", "given": "Goce", "initials": "G"}, {"family": "Wiech", "given": "Thorsten", "initials": "T"}, {"family": "Staessen", "given": "Jan", "initials": "J"}, {"family": "Wolf", "given": "Johannes", "initials": "J"}, {"family": "Beige", "given": "Joachim", "initials": "J"}], "type": "posted-content", "published": "2021-02-23", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.22.21252207", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-24T06:19:47.773Z", "modified": "2021-02-26T08:45:47.876Z"}, {"entity": "publication", "iuid": "3a3d1d8fbf594a02997f31c228efb07e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a3d1d8fbf594a02997f31c228efb07e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a3d1d8fbf594a02997f31c228efb07e"}}, "title": "Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients.", "authors": [{"family": "Zhao", "given": "Yu", "initials": "Y"}, {"family": "Kilian", "given": "Christoph", "initials": "C"}, {"family": "Turner", "given": "Jan-Eric", "initials": "JE"}, {"family": "Bosurgi", "given": "Lidia", "initials": "L"}, {"family": "Roedl", "given": "Kevin", "initials": "K"}, {"family": "Bartsch", "given": "Patricia", "initials": "P"}, {"family": "Gnirck", "given": "Ann-Christin", "initials": "AC"}, {"family": "Cortesi", "given": "Filippo", "initials": "F"}, {"family": "Schulthei\u00df", "given": "Christoph", "initials": "C"}, {"family": "Hellmig", "given": "Malte", "initials": "M"}, {"family": "Enk", "given": "Leon U B", "initials": "LUB"}, {"family": "Hausmann", "given": "Fabian", "initials": "F"}, {"family": "Borchers", "given": "Alina", "initials": "A"}, {"family": "Wong", "given": "Milagros N", "initials": "MN"}, {"family": "Paust", "given": "Hans-Joachim", "initials": "HJ"}, {"family": "Siracusa", "given": "Francesco", "initials": "F"}, {"family": "Scheibel", "given": "Nicola", "initials": "N"}, {"family": "Herrmann", "given": "Marissa", "initials": "M"}, {"family": "Rosati", "given": "Elisa", "initials": "E"}, {"family": "Bacher", "given": "Petra", "initials": "P"}, {"family": "Kylies", "given": "Dominik", "initials": "D"}, {"family": "Jarczak", "given": "Dominik", "initials": "D"}, {"family": "L\u00fctgehetmann", "given": "Marc", "initials": "M"}, {"family": "Pfefferle", "given": "Susanne", "initials": "S"}, {"family": "Steurer", "given": "Stefan", "initials": "S"}, {"family": "Zur-Wiesch", "given": "Julian Schulze", "initials": "JS"}, {"family": "Puelles", "given": "Victor G", "initials": "VG"}, {"family": "Sperhake", "given": "Jan-Peter", "initials": "JP"}, {"family": "Addo", "given": "Marylyn M", "initials": "MM"}, {"family": "Lohse", "given": "Ansgar W", "initials": "AW"}, {"family": "Binder", "given": "Mascha", "initials": "M"}, {"family": "Huber", "given": "Samuel", "initials": "S"}, {"family": "Huber", "given": "Tobias B", "initials": "TB"}, {"family": "Kluge", "given": "Stefan", "initials": "S"}, {"family": "Bonn", "given": "Stefan", "initials": "S"}, {"family": "Panzer", "given": "Ulf", "initials": "U"}, {"family": "Gagliani", "given": "Nicola", "initials": "N"}, {"family": "Krebs", "given": "Christian F", "initials": "CF"}], "type": "journal article", "published": "2021-02-23", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "volume": "6", "issue": "56", "issn-l": "2470-9468"}, "abstract": "Hyperinflammation contributes to lung injury and subsequent acute respiratory distress syndrome (ARDS) with high mortality in patients with severe coronavirus disease 2019 (COVID-19). To understand the underlying mechanisms involved in lung pathology, we investigated the role of the lung-specific immune response. We profiled immune cells in bronchoalveolar lavage fluid and blood collected from COVID-19 patients with severe disease and bacterial pneumonia patients not associated with viral infection. By tracking T cell clones across tissues, we identified clonally expanded tissue-resident memory-like Th17 cells (Trm17 cells) in the lungs even after viral clearance. These Trm17 cells were characterized by a a potentially pathogenic cytokine expression profile of IL17A and CSF2 (GM-CSF). Interactome analysis suggests that Trm17 cells can interact with lung macrophages and cytotoxic CD8+ T cells, which have been associated with disease severity and lung damage. High IL-17A and GM-CSF protein levels in the serum of COVID-19 patients were associated with a more severe clinical course. Collectively, our study suggests that pulmonary Trm17 cells are one potential orchestrator of the hyperinflammation in severe COVID-19.", "doi": "10.1126/sciimmunol.abf6692", "pmid": "33622974", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6/56/eabf6692"}], "notes": [], "created": "2021-02-25T12:27:16.311Z", "modified": "2021-02-26T08:45:48.060Z"}, {"entity": "publication", "iuid": "1b7f181e2f4d46e098cde3f9ce275f58", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b7f181e2f4d46e098cde3f9ce275f58.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b7f181e2f4d46e098cde3f9ce275f58"}}, "title": "The Outcome of Critically Ill COVID-19 Patients Is Linked to Thromboinflammation Dominated by the Kallikrein/Kinin System.", "authors": [{"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Persson", "given": "Barbro", "initials": "B"}, {"family": "Eriksson", "given": "Oskar", "initials": "O"}, {"family": "Blom", "given": "Anna M", "initials": "AM"}, {"family": "Fromell", "given": "Karin", "initials": "K"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Huber-Lang", "given": "Markus", "initials": "M"}, {"family": "Ekdahl", "given": "Kristina N", "initials": "KN"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Nilsson", "given": "Bo", "initials": "B"}], "type": "journal article", "published": "2021-02-22", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "12", "issue": null, "pages": "627579"}, "abstract": "An important manifestation of severe COVID-19 is the ARDS-like lung injury that is associated with vascular endothelialitis, thrombosis, and angiogenesis. The intravascular innate immune system (IIIS), including the complement, contact, coagulation, and fibrinolysis systems, which is crucial for recognizing and eliminating microorganisms and debris in the body, is likely to be involved in the pathogenesis of COVID-19 ARDS. Biomarkers for IIIS activation were studied in the first 66 patients with COVID-19 admitted to the ICU in Uppsala University Hospital, both cross-sectionally on day 1 and in 19 patients longitudinally for up to a month, in a prospective study. IIIS analyses were compared with biochemical parameters and clinical outcome and survival. Blood cascade systems activation leading to an overreactive conjunct thromboinflammation was demonstrated, reflected in consumption of individual cascade system components, e.g., FXII, prekallikrein, and high molecular weight kininogen and in increased levels of activation products, e.g., C4d, C3a, C3d,g, sC5b-9, TAT, and D-dimer. Strong associations were found between the blood cascade systems and organ damage, illness severity scores, and survival. We show that critically ill COVID-19 patients display a conjunct activation of the IIIS that is linked to organ damage of the lung, heart, kidneys, and death. We present evidence that the complement and in particular the kallikrein/kinin system is strongly activated and that both systems are prognostic markers of the outcome of the patients suggesting their role in driving the inflammation. Already licensed kallikrein/kinin inhibitors are potential drugs for treatment of critically ill patients with COVID-19.", "doi": "10.3389/fimmu.2021.627579", "pmid": "33692801", "labels": {"Funder: VR": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pmc", "key": "PMC7937878"}], "notes": [], "created": "2021-03-12T06:30:27.350Z", "modified": "2022-02-14T15:59:07.466Z"}, {"entity": "publication", "iuid": "59c5edd4606e4ff6b9b1f5c02df9ffb5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/59c5edd4606e4ff6b9b1f5c02df9ffb5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/59c5edd4606e4ff6b9b1f5c02df9ffb5"}}, "title": "Indirect Immunofluorescence for Detecting Anti-Neuronal Autoimmunity in CSF after COVID-19 - Possibilities and Pitfalls.", "authors": [{"family": "Mulder", "given": "Jan", "initials": "J"}, {"family": "Lindqvist", "given": "Isa", "initials": "I"}, {"family": "Rasmusson", "given": "Annica J", "initials": "AJ"}, {"family": "Hus\u00e9n", "given": "Evelina", "initials": "E"}, {"family": "R\u00f6nnelid", "given": "Johan", "initials": "J"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "Cunningham", "given": "Janet L", "initials": "JL"}], "type": "letter", "published": "2021-02-22", "journal": {"title": "Brain Behav Immun", "issn": "1090-2139", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/j.bbi.2021.02.013", "pmid": "33631284", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S0889-1591(21)00078-7"}], "notes": [], "created": "2021-03-01T10:24:42.657Z", "modified": "2021-03-01T10:25:01.801Z"}, {"entity": "publication", "iuid": "463bf10b1aa84edb89f6a8d116341e93", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/463bf10b1aa84edb89f6a8d116341e93.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/463bf10b1aa84edb89f6a8d116341e93"}}, "title": "Frailty and comorbidity in predicting community COVID \u201019 mortality in the UK Biobank: the effect of sampling", "authors": [{"family": "Mak", "given": "Jonathan K L", "initials": "JKL"}, {"family": "Kuja\u2010Halkola", "given": "Ralf", "initials": "R"}, {"family": "Wang", "given": "Yunzhang", "initials": "Y"}, {"family": "H\u00e4gg", "given": "Sara", "initials": "S"}, {"family": "Jylh\u00e4v\u00e4", "given": "Juulia", "initials": "J"}], "type": "journal-article", "published": "2021-02-22", "journal": {"title": "J Am Geriatr Soc", "issn": "0002-8614", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1111/jgs.17089", "pmid": null, "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-24T06:15:15.735Z", "modified": "2021-06-18T14:21:14.474Z"}, {"entity": "publication", "iuid": "f7f307cb36194462b403a98c216e3d2f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7f307cb36194462b403a98c216e3d2f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7f307cb36194462b403a98c216e3d2f"}}, "title": "Digitalizing a Brief Intervention to Reduce Intrusive Memories of Psychological Trauma: Qualitative Interview Study", "authors": [{"family": "Gamble", "given": "Beau", "initials": "B"}, {"family": "Depa", "given": "Katherine", "initials": "K"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}, {"family": "Kanstrup", "given": "Marie", "initials": "M"}], "type": "journal-article", "published": "2021-02-22", "journal": {"title": "JMIR Ment Health", "issn": "2368-7959", "volume": "8", "issue": "2", "pages": "e23712", "issn-l": null}, "abstract": null, "doi": "10.2196/23712", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-23T07:12:28.728Z", "modified": "2021-02-26T08:47:00.316Z"}, {"entity": "publication", "iuid": "ebceb4aab75b41cf84f88db076202122", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ebceb4aab75b41cf84f88db076202122.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ebceb4aab75b41cf84f88db076202122"}}, "title": "COVID-19, Religious Coping, and Weight Change in the Orthodox Jewish Community.", "authors": [{"family": "Pirutinsky", "given": "Steven", "initials": "S"}, {"family": "Cherniak", "given": "Aaron D", "initials": "AD"}, {"family": "Rosmarin", "given": "David H", "initials": "DH"}], "type": "journal article", "published": "2021-02-21", "journal": {"title": "J Relig Health", "issn": "1573-6571", "volume": null, "issue": null, "issn-l": null}, "abstract": "Given links between stress and obesity, it is likely that individuals gained weight during the COVID-19 lockdown. Research suggests that religiosity facilitates coping, which may have lessened the relationship between stress and weight gain during the COVID-19 lockdown. We examined this relationship among Orthodox Jews (n = 731). Results indicated that stress was marginally associated with weight gain, and that this was moderated by intrinsic religiosity (IR). For those with low IR, stress correlated with weight gain, while for those with mean or higher IR, stress and weight change were unrelated. Results suggest that for some, religiosity may moderate links between stress and weight gain during times of crisis.", "doi": "10.1007/s10943-021-01196-8", "pmid": "33611679", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10943-021-01196-8"}], "notes": [], "created": "2021-02-22T11:50:52.955Z", "modified": "2021-02-26T08:47:00.290Z"}, {"entity": "publication", "iuid": "d17e971be14a4a93a6cff389f61af531", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d17e971be14a4a93a6cff389f61af531.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d17e971be14a4a93a6cff389f61af531"}}, "title": "Separation of power and expertise: Evidence of the tyranny of experts in Sweden's COVID-19 responses.", "authors": [{"family": "Bylund", "given": "Per L", "initials": "PL"}, {"family": "Packard", "given": "Mark D", "initials": "MD"}], "type": "journal article", "published": "2021-02-19", "journal": {"title": "South Econ J", "issn": "0038-4038", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Whereas most countries in the COVID-19 pandemic imposed shutdowns and curfews to mitigate the contagion, Sweden uniquely pursued a more voluntarist approach. In this article, our interest is primarily on how and why Sweden's approach to the pandemic was so unique. There are two parts to this research question: (1) why did virtually all other nations follow a radical lockdown protocol despite limited evidence to its effectiveness and (2) why did Sweden not follow this same protocol despite strong political pressures? The answers to these questions lie within typical government technocracy versus Sweden's constitutional separation of government and technocracy. We review the history of the responses to the pandemic and show how the \"tyranny of experts\" was severe within the typical technocratic policy response, and attenuated in Sweden's. Thus, the recent pandemic offers empirical evidence and insights regarding the role of Hayekian knowledge problems in engendering a technocratic \"tyranny of experts\" and how such effects can be structurally mitigated.", "doi": "10.1002/soej.12493", "pmid": "33821054", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "SOEJ12493"}, {"db": "pmc", "key": "PMC8014802"}], "notes": [], "created": "2021-04-07T10:11:20.636Z", "modified": "2021-04-07T10:11:49.163Z"}, {"entity": "publication", "iuid": "d90e9a3eae6845369c634f138fa5ee49", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d90e9a3eae6845369c634f138fa5ee49.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d90e9a3eae6845369c634f138fa5ee49"}}, "title": "Promoting Mental Health and Well-Being among Adolescent Young Carers in Europe: A Randomized Controlled Trial Protocol.", "authors": [{"family": "Casu", "given": "Giulia", "initials": "G"}, {"family": "Hlebec", "given": "Valentina", "initials": "V"}, {"family": "Boccaletti", "given": "Licia", "initials": "L"}, {"family": "Bolko", "given": "Irena", "initials": "I"}, {"family": "Manattini", "given": "Alessandra", "initials": "A"}, {"family": "Hanson", "given": "Elizabeth", "initials": "E"}], "type": "journal article", "published": "2021-02-19", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "4", "pages": null}, "abstract": "It is estimated that 4-8% of youth in Europe carry out substantial care for a family member or significant other. To prevent adverse psychosocial outcomes in young carers (YCs), primary prevention resilience building interventions have been recommended. We describe the study protocol of an international randomized controlled trial (RCT) of an innovative group intervention designed to promote the mental health and well-being of adolescent YCs (AYCs) aged 15-17. The RCT will be conducted in six European countries in the context of the Horizon 2020 European funded research and innovation project \"Psychosocial support for promoting mental health and well-being among adolescent young caregivers in Europe\" (\"ME-WE\"). The ME-WE intervention is based on Hayes and Ciarrochi's psychoeducational model for adolescents and will consist of seven 2-h sessions in a group format, aimed to help AYCs build psychological flexibility and live according to their values. The control group will be a waitlist. Primary and secondary outcomes and control variables will be measured at baseline (T0), post-intervention (T1) and 3 months follow-up (T2). The COVID-19 pandemic has made amendments necessary to the original study protocol methodology, which we describe in detail. This study will contribute to building an evidence-based manualized program that educators and health and social care professionals can use to support AYCs in their transition to adulthood. From a research perspective, the outcomes of this study will contribute to evidence-based practices in primary prevention of psychosocial difficulties in AYCs and will gather novel knowledge on the effectiveness of Hayes and Ciarrochi's model for use with middle adolescents with caring responsibilities. The trial has been preregistered (registration number: NCT04114864).", "doi": "10.3390/ijerph18042045", "pmid": "33669796", "labels": {"Category: Public Health": null, "Type: Journal article": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "ijerph18042045"}, {"db": "ClinicalTrials.gov", "key": "NCT04114864"}], "notes": [], "created": "2021-03-08T10:54:03.463Z", "modified": "2021-06-18T12:16:05.877Z"}, {"entity": "publication", "iuid": "681a63ed4b294f4abe9209a1d989d4e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/681a63ed4b294f4abe9209a1d989d4e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/681a63ed4b294f4abe9209a1d989d4e7"}}, "title": "Opposing Vaccine Hesitancy During the Covid-19 Pandemic - A Critical Commentary and United Statement of an International Osteopathic Research Community.", "authors": [{"family": "Thomson", "given": "Oliver P", "initials": "OP"}, {"family": "MacMillan", "given": "Andrew", "initials": "A"}, {"family": "Draper-Rodi", "given": "Jerry", "initials": "J"}, {"family": "Vaucher", "given": "Paul", "initials": "P"}, {"family": "M\u00e9nard", "given": "Mathieu", "initials": "M"}, {"family": "Vaughan", "given": "Brett", "initials": "B"}, {"family": "Morin", "given": "Chantal", "initials": "C"}, {"family": "Alvarez", "given": "Gerard", "initials": "G"}, {"family": "Sampath", "given": "Kesava Kovanur", "initials": "KK"}, {"family": "Cerritelli", "given": "Francesco", "initials": "F"}, {"family": "Shaw", "given": "Robert", "initials": "R"}, {"family": "Cymet", "given": "Tyler C", "initials": "TC"}, {"family": "Bright", "given": "Philip", "initials": "P"}, {"family": "Hohenschurz-Schmidt", "given": "David", "initials": "D"}, {"family": "Vogel", "given": "Steven", "initials": "S"}], "type": "editorial", "published": "2021-02-19", "journal": {"title": "Int J Osteopath Med", "issn": "1746-0689", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.ijosm.2021.02.002", "pmid": "33623534", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1746-0689(21)00005-5"}, {"db": "pmc", "key": "PMC7893309"}], "notes": [], "created": "2021-02-25T10:11:47.768Z", "modified": "2021-02-25T10:11:53.052Z"}, {"entity": "publication", "iuid": "3d38032e50e44e79976f38229ffa6e4f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3d38032e50e44e79976f38229ffa6e4f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3d38032e50e44e79976f38229ffa6e4f"}}, "title": "Notes from afar: reflections from two Australian intensivists in Sweden during the COVID-19 pandemic.", "authors": [{"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Halliday", "given": "Thomas", "initials": "T"}], "type": "letter", "published": "2021-02-19", "journal": {"title": "Med J Aust", "issn": "1326-5377", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.5694/mja2.50949", "pmid": "33608964", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-22T11:49:45.169Z", "modified": "2021-02-22T11:49:45.191Z"}, {"entity": "publication", "iuid": "6118df012a05421baa922beeefe40c9f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6118df012a05421baa922beeefe40c9f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6118df012a05421baa922beeefe40c9f"}}, "title": "Microsurgery training during COVID-19 pandemic: Practical recommendations from the International Society for Experimental Microsurgery and International Microsurgery Simulation Society.", "authors": [{"family": "Oltean", "given": "Mihai", "initials": "M"}, {"family": "Nistor", "given": "Alexandru", "initials": "A"}, {"family": "Hellstr\u00f6m", "given": "Mats", "initials": "M"}, {"family": "Axelsson", "given": "Michael", "initials": "M"}, {"family": "Yagi", "given": "Shintaro", "initials": "S"}, {"family": "Kobayashi", "given": "Eiji", "initials": "E"}, {"family": "Ballestin", "given": "Alberto", "initials": "A"}, {"family": "Akelina", "given": "Yelena", "initials": "Y"}, {"family": "Nemeth", "given": "Norbert", "initials": "N"}], "type": "editorial", "published": "2021-02-19", "journal": {"title": "Microsurgery", "issn": "1098-2752", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1002/micr.30725", "pmid": "33606305", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-22T11:47:59.892Z", "modified": "2021-02-22T11:49:22.216Z"}, {"entity": "publication", "iuid": "a7817eb57bdf490c9e490c19a8dabe4f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7817eb57bdf490c9e490c19a8dabe4f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7817eb57bdf490c9e490c19a8dabe4f"}}, "title": "Different disease, same challenges: Social determinants of tuberculosis and COVID-19.", "authors": [{"family": "Duarte", "given": "R", "initials": "R"}, {"family": "Aguiar", "given": "A", "initials": "A"}, {"family": "Pinto", "given": "M", "initials": "M"}, {"family": "Furtado", "given": "I", "initials": "I"}, {"family": "Tiberi", "given": "S", "initials": "S"}, {"family": "L\u00f6nnroth", "given": "K", "initials": "K"}, {"family": "Migliori", "given": "G B", "initials": "GB"}], "type": "journal article", "published": "2021-02-19", "journal": {"title": "Pulmonology", "issn": "2531-0437", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Infectious diseases, such as tuberculosis (TB) and the novel coronavirus (COVID-19) relate to environmental factors, understanding of which is essential to inform policy and practice and tackle them effectively. The review follows the conceptual framework offered by the World Health Organization Commission on Social Determinants of Health (defined as \"all those material, psychological and behavioural circumstances linked to health and generically indicated as risk factors' in the conventional epidemiological language\"). It describes the social factors behind TB and COVID-19, the commonalities between the two diseases, and what can be learned so far from the published best practices. The social determinants sustaining TB and COVID-19 underline the importance of prioritising health and allocating adequate financial and human resources to achieve universal health coverage and health-related social protection while addressing the needs of vulnerable populations. Rapid and effective measures against poverty and other major social determinants and sources of inequality are urgently needed to develop better health in the post-COVID-19 world.", "doi": "10.1016/j.pulmoe.2021.02.002", "pmid": "33648891", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S2531-0437(21)00048-9"}], "notes": [], "created": "2021-03-03T17:00:21.196Z", "modified": "2021-06-18T12:27:09.827Z"}, {"entity": "publication", "iuid": "51a1f0cc535542d8a7e55dbdad9731ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/51a1f0cc535542d8a7e55dbdad9731ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/51a1f0cc535542d8a7e55dbdad9731ef"}}, "title": "COVID-19: From health crises to food security anxiety and policy implications.", "authors": [{"family": "Chiwona-Karltun", "given": "Linley", "initials": "L"}, {"family": "Amuakwa-Mensah", "given": "Franklin", "initials": "F"}, {"family": "Wamala-Larsson", "given": "Caroline", "initials": "C"}, {"family": "Amuakwa-Mensah", "given": "Salome", "initials": "S"}, {"family": "Abu Hatab", "given": "Assem", "initials": "A"}, {"family": "Made", "given": "Nolwandle", "initials": "N"}, {"family": "Taremwa", "given": "Nathan Kanuma", "initials": "NK"}, {"family": "Melyoki", "given": "Lemayon", "initials": "L"}, {"family": "Rutashobya", "given": "Lettice Kinunda", "initials": "LK"}, {"family": "Madonsela", "given": "Thulisile", "initials": "T"}, {"family": "Lourens", "given": "Marna", "initials": "M"}, {"family": "Stone", "given": "Wendy", "initials": "W"}, {"family": "Bizoza", "given": "Alfred R", "initials": "AR"}], "type": "journal article", "published": "2021-02-19", "journal": {"title": "Ambio", "issn": "1654-7209", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Like the rest of the world, African countries are reeling from the health, economic and social effects of COVID-19. The continent's governments have responded by imposing rigorous lockdowns to limit the spread of the virus. The various lockdown measures are undermining food security, because stay at home orders have among others, threatened food production for a continent that relies heavily on agriculture as the bedrock of the economy. This article draws on quantitative data collected by the GeoPoll, and, from these data, assesses the effect of concern about the local spread and economic impact of COVID-19 on food worries. Qualitative data comprising 12 countries south of the Sahara reveal that lockdowns have created anxiety over food security as a health, economic and human rights/well-being issue. By applying a probit model, we find that concern about the local spread of COVID-19 and economic impact of the virus increases the probability of food worries. Governments have responded with various efforts to support the neediest. By evaluating the various policies rolled out we advocate for a feminist economics approach that necessitates greater use of data analytics to predict the likely impacts of intended regulatory relief responses during the recovery process and post-COVID-19.", "doi": "10.1007/s13280-020-01481-y", "pmid": "33606247", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s13280-020-01481-y"}], "notes": [], "created": "2021-02-22T11:45:22.176Z", "modified": "2021-06-18T12:28:21.236Z"}, {"entity": "publication", "iuid": "67a263a9b3b24ca9bf17cf8e24179ae6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/67a263a9b3b24ca9bf17cf8e24179ae6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/67a263a9b3b24ca9bf17cf8e24179ae6"}}, "title": "Transparency in Negotiation of European Union With Big Pharma on COVID-19 Vaccines.", "authors": [{"family": "Sciacchitano", "given": "Salvatore", "initials": "S"}, {"family": "Bartolazzi", "given": "Armando", "initials": "A"}], "type": "journal article", "published": "2021-02-18", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "issue": null, "pages": "647955", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2021.647955", "pmid": "33681138", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7930234"}], "notes": [], "created": "2021-03-09T15:35:17.044Z", "modified": "2021-03-09T15:38:10.721Z"}, {"entity": "publication", "iuid": "c811df8a6c9740759e2469610833548b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c811df8a6c9740759e2469610833548b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c811df8a6c9740759e2469610833548b"}}, "title": "Primary Immunodeficiencies: A Decade of Progress and a Promising Future.", "authors": [{"family": "Meyts", "given": "Isabelle", "initials": "I"}, {"family": "Bousfiha", "given": "Aziz", "initials": "A"}, {"family": "Duff", "given": "Carla", "initials": "C"}, {"family": "Singh", "given": "Surjit", "initials": "S"}, {"family": "Lau", "given": "Yu Lung", "initials": "YL"}, {"family": "Condino-Neto", "given": "Antonio", "initials": "A"}, {"family": "Bezrodnik", "given": "Liliana", "initials": "L"}, {"family": "Ali", "given": "Adli", "initials": "A"}, {"family": "Adeli", "given": "Mehdi", "initials": "M"}, {"family": "Drabwell", "given": "Jose", "initials": "J"}], "type": "journal article", "published": "2021-02-18", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "11", "issue": null, "pages": "625753", "issn-l": "1664-3224"}, "abstract": null, "doi": "10.3389/fimmu.2020.625753", "pmid": "33679719", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7935502"}], "notes": [], "created": "2021-03-09T15:37:08.145Z", "modified": "2021-03-09T15:37:08.155Z"}, {"entity": "publication", "iuid": "4262013c82c143d8991de666f365484f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4262013c82c143d8991de666f365484f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4262013c82c143d8991de666f365484f"}}, "title": "Open Schools, Covid-19, and Child and Teacher Morbidity in Sweden.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF", "orcid": "0000-0003-1024-5602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1d5e45881a7469ca20a0eb360d891cc.json"}}, {"family": "Engerstr\u00f6m", "given": "Lars", "initials": "L"}, {"family": "Nordenh\u00e4ll", "given": "Charlotta", "initials": "C"}, {"family": "Larsson", "given": "Emma", "initials": "E"}], "type": "letter", "published": "2021-02-18", "journal": {"title": "N Engl J Med", "issn": "1533-4406", "issn-l": null, "volume": "384", "issue": "7", "pages": "669-671"}, "abstract": "Letter to Editor", "doi": "10.1056/NEJMc2026670", "pmid": "33406327", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7821981"}], "notes": [], "created": "2021-01-07T09:53:32.558Z", "modified": "2023-01-05T09:34:44.061Z"}, {"entity": "publication", "iuid": "dbba08ac3a844ce3a632411d77f7c4f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dbba08ac3a844ce3a632411d77f7c4f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dbba08ac3a844ce3a632411d77f7c4f0"}}, "title": "Mortality of the COVID-19 Outbreak in Sweden in Relation to Previous Severe Disease Outbreaks.", "authors": [{"family": "Ledberg", "given": "Anders", "initials": "A"}], "type": "historical article", "published": "2021-02-18", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "issue": null, "pages": "579948", "issn-l": "2296-2565"}, "abstract": "Influenza viruses have caused disease outbreaks in human societies for a long time. Influenza often has rapid onset and relatively short duration, both in the individual and in the population. The case fatality rate varies for different strains of the virus, as do the effects on total mortality. Outbreaks related to coronavirus infections have recently become a global concern but much less is known about the dynamics of these outbreaks and their effects on mortality. In this work, disease outbreaks in Sweden, in the time period of 1860-2020, are characterized and compared to the currently ongoing COVID-19 outbreak. The focus is on outbreaks with a sharp increase in all-cause mortality. Outbreak onset is defined as the time point when death counts start to increase consistently for a period of at least 10 days. The duration of the outbreak is defined as the time period in which mortality rates are elevated. Excess mortality is estimated by standard methods. In total there were 15 outbreaks detected in the time period, the first 14 were likely caused by influenza virus infections, the last by SARS-CoV-2. The mortality dynamics of the SARS-CoV-2 outbreak is shown to be similar to outbreaks due to influenza virus, and in terms of the number of excess deaths, it is the worst outbreak in Sweden since the \"Spanish flu\" of 1918-1919.", "doi": "10.3389/fpubh.2021.579948", "pmid": "33681118", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7930003"}], "notes": [], "created": "2021-03-09T15:34:43.443Z", "modified": "2023-01-13T14:42:10.712Z"}, {"entity": "publication", "iuid": "56fe137526f642b09109307e1e3d002c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56fe137526f642b09109307e1e3d002c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56fe137526f642b09109307e1e3d002c"}}, "title": "COVID-19: A methyl-group assault?", "authors": [{"family": "McCaddon", "given": "Andrew", "initials": "A"}, {"family": "Regland", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2021-02-18", "journal": {"title": "Med Hypotheses", "issn": "1532-2777", "volume": "149", "issue": null, "pages": "110543", "issn-l": null}, "abstract": "The socio-economic implications of COVID-19 are devastating. Considerable morbidity is attributed to 'long-COVID' - an increasingly recognized complication of infection. Its diverse symptoms are reminiscent of vitamin B 12 deficiency, a condition in which methylation status is compromised. We suggest why SARS-CoV-2 infection likely leads to increased methyl-group requirements and other disturbances of one-carbon metabolism. We propose these might explain the varied symptoms of long-COVID. Our suggested mechanismmight also apply to similar conditions such as myalgic encephalomyelitis/chronic fatigue syndrome. The hypothesis is evaluable by detailed determination of vitamin B12and folate status, including serum formate as well as homocysteine and methylmalonic acid, and correlation with viral and host RNA methylation and symptomatology. If confirmed, methyl-group support should prove beneficial in such individuals.", "doi": "10.1016/j.mehy.2021.110543", "pmid": "33657459", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0306-9877(21)00061-X"}], "notes": [], "created": "2021-03-04T14:56:44.491Z", "modified": "2021-03-04T14:56:44.501Z"}, {"entity": "publication", "iuid": "2776c89c8fbb490faa3383929ae5e355", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2776c89c8fbb490faa3383929ae5e355.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2776c89c8fbb490faa3383929ae5e355"}}, "title": "No Apparent Increase in Treatment Uptake for Gambling Disorder during Ten Months of the COVID-19 Pandemic-Analysis of a Regional Specialized Treatment Unit in Sweden.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "\u00c5kesson", "given": "Gunny", "initials": "G"}, {"family": "Grudet", "given": "C\u00e9cile", "initials": "C"}, {"family": "Broman", "given": "Niroshani", "initials": "N"}], "type": "journal article", "published": "2021-02-17", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "4", "pages": null}, "abstract": "The COVID-19 pandemic and its impact on society has been suspected to affect gambling behaviors. Potentially, the pandemic crisis may result in increased problem gambling, for example, due to COVID-19-related psychological distress, unemployment, and financial difficulties. In addition, the cancellation of sports in early parts of the crisis has been suspected to alter gambling behaviors. Policy makers have called for action and, in some cases, have changed regulations, and media have reported possible increases in treatment seeking. However, research data are hitherto lacking. The present study assessed the treatment uptake at a regional specialized gambling-disorder unit in the healthcare system of Region Sk\u00e5ne, Sweden. Number of patients, treatment contacts, and patterns of rescheduling or cancellations of appointments were quantified for each month, January-December 2020, and compared to corresponding months of 2018 and 2019. Possible trends were analyzed, using an interrupted time-series analysis. Results did not indicate an increase in treatment uptake for gambling disorder during the months of COVID-19 impact in Sweden. The proportion of digital treatment increased, but total treatment uptake was unaffected by the pandemic. In conclusion, during the first ten months of the pandemic in Sweden, no obvious increase in treatment uptake for gambling disorder could be seen. Moreover, longer follow-up may be necessary in order to see if effects of worsening socioeconomic conditions may be a possible long-term risk factor of increased gambling after COVID-19.", "doi": "10.3390/ijerph18041918", "pmid": "33671210", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph18041918"}], "notes": [], "created": "2021-03-08T10:55:33.867Z", "modified": "2021-06-18T12:13:22.550Z"}, {"entity": "publication", "iuid": "4fd3a6db29284949ba20ab51f116fca8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4fd3a6db29284949ba20ab51f116fca8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4fd3a6db29284949ba20ab51f116fca8"}}, "title": "Impacts of COVID-19 on long-term health and health care use", "authors": [{"family": "Skyrud", "given": "Katrine", "initials": "K", "orcid": "0000-0001-7504-9253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa7b45c41c544ba098093febd55117c8.json"}}, {"family": "Hern\u00e6s", "given": "Kjersti Helene", "initials": "KH"}, {"family": "Telle", "given": "Kjetil", "initials": "K", "orcid": "0000-0002-7978-0825", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21c273a80c5c4976bd93f15f2e038f40.json"}}, {"family": "Magnusson", "given": "Karin", "initials": "K", "orcid": "0000-0003-4851-5794", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2fe6a28f36f40a998b8c9fc3c5ebe73.json"}}], "type": "posted-content", "published": "2021-02-17", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.16.21251807", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-18T11:03:10.874Z", "modified": "2022-11-22T05:53:14.152Z"}, {"entity": "publication", "iuid": "c5613dca3ecd449180e010846b313144", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5613dca3ecd449180e010846b313144.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5613dca3ecd449180e010846b313144"}}, "title": "Association between cardiometabolic disease and severe COVID-19: a nationwide case-control study of patients requiring invasive mechanical ventilation.", "authors": [{"family": "Svensson", "given": "Per", "initials": "P"}, {"family": "Hofmann", "given": "Robin", "initials": "R"}, {"family": "H\u00e4bel", "given": "Henrike", "initials": "H"}, {"family": "Jernberg", "given": "Tomas", "initials": "T"}, {"family": "Nordberg", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2021-02-17", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "2", "pages": "e044486"}, "abstract": "The risks associated with diabetes, obesity and hypertension for severe COVID-19 may be confounded and differ by sociodemographic background. We assessed the risks associated with cardiometabolic factors for severe COVID-19 when accounting for socioeconomic factors and in subgroups by age, sex and region of birth.\r\n\r\nIn this nationwide case-control study, 1.086 patients admitted to intensive care with COVID-19 requiring mechanical ventilation (cases), and 10.860 population-based controls matched for age, sex and district of residency were included from mandatory national registries. ORs with 95% CIs for associations between severe COVID-19 and exposures with adjustment for confounders were estimated using logistic regression. The median age was 62 years (IQR 52-70), and 3003 (24.9%) were women. Type 2 diabetes (OR, 2.3 (95% CI 1.9 to 2.7)), hypertension (OR, 1.7 (95% CI 1.5 to 2.0)), obesity (OR, 3.1 (95% CI 2.4 to 4.0)) and chronic kidney disease (OR, 2.5 (95% CI 1.7 to 3.7)) were all associated with severe COVID-19. In the younger subgroup (below 57 years), ORs were significantly higher for all cardiometabolic risk factors. The risk associated with type 2 diabetes was higher in women (p=0.001) and in patients with a region of birth outside European Union(EU) (p=0.004).\r\n\r\nDiabetes, obesity and hypertension were all independently associated with severe COVID-19 with stronger associations in the younger population. Type 2 diabetes implied a greater risk among women and in non-EU immigrants. These findings, originating from high-quality Swedish registries, may be important to direct preventive measures such as vaccination to susceptible patient groups.\r\n\r\nClinicaltrial.gov (NCT04426084).", "doi": "10.1136/bmjopen-2020-044486", "pmid": "33597145", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-044486"}, {"db": "ClinicalTrials.gov", "key": "NCT04426084"}], "notes": [], "created": "2021-02-19T06:22:45.933Z", "modified": "2021-06-18T12:06:53.712Z"}, {"entity": "publication", "iuid": "4b0f1b1ea560426c8ef9e4bb44326d3f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b0f1b1ea560426c8ef9e4bb44326d3f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b0f1b1ea560426c8ef9e4bb44326d3f"}}, "title": "Extracorporeal Life Support in COVID-19-related Acute Respiratory Distress Syndrome - a EuroELSO international survey.", "authors": [{"family": "Mang", "given": "Sebastian", "initials": "S"}, {"family": "Kalenka", "given": "Armin", "initials": "A"}, {"family": "Broman", "given": "Lars Mikael", "initials": "LM"}, {"family": "Supady", "given": "Alexander", "initials": "A"}, {"family": "Swol", "given": "Justyna", "initials": "J"}, {"family": "Danziger", "given": "Guy", "initials": "G"}, {"family": "Becker", "given": "Andr\u00e9", "initials": "A"}, {"family": "H\u00f6rsch", "given": "Sabrina I", "initials": "SI"}, {"family": "Mertke", "given": "Thilo", "initials": "T"}, {"family": "Kaiser", "given": "Ralf", "initials": "R"}, {"family": "Bracht", "given": "Hendrik", "initials": "H"}, {"family": "Zotzmann", "given": "Viviane", "initials": "V"}, {"family": "Seiler", "given": "Frederik", "initials": "F"}, {"family": "Bals", "given": "Robert", "initials": "R"}, {"family": "Taccone", "given": "Fabio Silvio", "initials": "FS"}, {"family": "Moerer", "given": "Onnen", "initials": "O"}, {"family": "Lorusso", "given": "Roberto", "initials": "R"}, {"family": "B\u011blohl\u00e1vek", "given": "Jan", "initials": "J"}, {"family": "Muellenbach", "given": "Ralf M", "initials": "RM"}, {"family": "Lepper", "given": "Philipp M", "initials": "PM"}, {"family": "COVEC-Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-02-16", "journal": {"title": "Artif Organs", "issn": "1525-1594", "volume": null, "issue": null, "issn-l": null}, "abstract": "Extracorporeal life support (ECLS) is a means to support patients with acute respiratory failure. Initially, recommendations to treat severe cases of pandemic Coronavirus Disease 2019 (COVID-19) with ECLS have been restrained. In the meantime, ECLS has been shown to produce similar outcomes in patients with severe COVID-19 compared to existing data on ARDS mortality.\n\nWe performed an international email survey to assess how ECLS providers worldwide have previously used ECLS during the treatment of critically ill patients with COVID-19.\n\nA questionnaire with 45 questions (covering e.g. indication, technical aspects, benefit and reasons for treatment discontinuation), mostly multiple-choice, was distributed by email to ECLS centers. The survey was approved by the European branch of the Extracorporeal Life Support Organization (ELSO).\n\n276 ECMO professionals from 98 centers in 30 different countries on four continents reported that they employed ECMO for very severe COVID-19 cases, mostly in veno-venous configuration (87%). The most common reason to establish ECLS was isolated hypoxemic respiratory failure (50%), followed by a combination of hypoxemia and hypercapnia (39%). Only a small fraction of patients required veno-arterial cannulation due to heart failure (3%). Time on ECLS varied between less than two and more than four weeks. The main reason to discontinue ECLS treatment prior to patient's recovery was lack of clinical improvement (53%), followed by major bleeding, mostly intracranially (13%). Only 4% of respondents reported that triage situations, lack of staff or lack of oxygenators were responsible for discontinuation of ECLS support. Most ECLS physicians (51%, IQR 30%) agreed that patients with COVID-19 induced ARDS (CARDS) benefitted from ECLS. Overall mortality of COVID-19 patients on ECLS was estimated to be about 55%.\n\nECLS has been utilized successfully during the COVID-19 pandemic to stabilize CARDS patients in hypoxemic or hypercapnic lung failure. Age and multimorbidity limited the use of ECLS. Triage situations were rarely a concern. ECLS providers stated that patients with severe COVID-19 benefitted from ECLS.", "doi": "10.1111/aor.13940", "pmid": "33590542", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-02-17T15:04:16.789Z", "modified": "2021-02-17T15:05:18.711Z"}, {"entity": "publication", "iuid": "93685b21b5ce4554bb28daffb4ac1ddb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/93685b21b5ce4554bb28daffb4ac1ddb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/93685b21b5ce4554bb28daffb4ac1ddb"}}, "title": "SARS-CoV2 envelop proteins reshape the serological responses of COVID-19 patients", "authors": [{"family": "Martin", "given": "Sophie", "initials": "S"}, {"family": "Heslan", "given": "Christopher", "initials": "C"}, {"family": "Jegou", "given": "Gwenaele", "initials": "G"}, {"family": "Eriksson", "given": "Leif A", "initials": "LA"}, {"family": "Le Gallo", "given": "Matthieu", "initials": "M"}, {"family": "Thibault", "given": "Vincent", "initials": "V"}, {"family": "Chevet", "given": "Eric", "initials": "E"}, {"family": "Avril", "given": "Tony", "initials": "T"}], "type": "posted-content", "published": "2021-02-15", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.15.431237", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-02-16T15:10:29.773Z", "modified": "2021-03-08T15:06:49.441Z"}, {"entity": "publication", "iuid": "b958e83e0e8d45cfa85481fec9b4d055", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b958e83e0e8d45cfa85481fec9b4d055.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b958e83e0e8d45cfa85481fec9b4d055"}}, "title": "Identification of endothelial-derived proteins in plasma associated with cardiovascular risk factors", "authors": [{"family": "Iglesias", "given": "MJ", "initials": "M"}, {"family": "LD", "given": "Kruse", "initials": "K"}, {"family": "Sanchez-Rivera", "given": "L", "initials": "L"}, {"family": "Enge", "given": "L", "initials": "L"}, {"family": "Dusart", "given": "P", "initials": "P"}, {"family": "Hong", "given": "MG", "initials": "M"}, {"family": "M Uhl\u00e9n", "given": "M", "initials": "M"}, {"family": "Renn\u00e9", "given": "T", "initials": "T"}, {"family": "Schwenk", "given": "JM", "initials": "J"}, {"family": "Bergstrom", "given": "G", "initials": "G"}, {"family": "Odeberg", "given": "J", "initials": "J"}, {"family": "Butler", "given": "LM", "initials": "L"}], "type": null, "published": "2021-02-15", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "https://doi.org/10.1101/2021.02.08.21251209", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-15T18:28:29.299Z", "modified": "2021-02-26T08:45:48.606Z"}, {"entity": "publication", "iuid": "27d452f2a66c49e18ad440c11fbe7456", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27d452f2a66c49e18ad440c11fbe7456.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27d452f2a66c49e18ad440c11fbe7456"}}, "title": "European Task Force on Atopic Dermatitis (ETFAD): position on vaccination of adult patients with atopic dermatitis against COVID-19 (SARS-CoV-2) being treated with systemic medication and biologics.", "authors": [{"family": "Thyssen", "given": "Jacob P", "initials": "JP"}, {"family": "Vestergaard", "given": "Christian", "initials": "C"}, {"family": "Barbarot", "given": "Sebastien", "initials": "S"}, {"family": "de Bruin-Weller", "given": "Marjolein S", "initials": "MS"}, {"family": "Bieber", "given": "Thomas", "initials": "T"}, {"family": "Taieb", "given": "Alain", "initials": "A"}, {"family": "Seneschal", "given": "Julien", "initials": "J"}, {"family": "Cork", "given": "Michael J", "initials": "MJ"}, {"family": "Paul", "given": "Carle", "initials": "C"}, {"family": "Flohr", "given": "Carsten", "initials": "C"}, {"family": "Weidinger", "given": "Stephan", "initials": "S"}, {"family": "Trzeciak", "given": "Magdalena", "initials": "M"}, {"family": "Werfel", "given": "Thomas", "initials": "T"}, {"family": "Heratizadeh", "given": "Annice", "initials": "A"}, {"family": "Darsow", "given": "Ulf", "initials": "U"}, {"family": "Simon", "given": "Dagmar", "initials": "D"}, {"family": "Torrelo", "given": "Antonio", "initials": "A"}, {"family": "Chernyshov", "given": "Pavel V", "initials": "PV"}, {"family": "Stalder", "given": "Jean-Francois", "initials": "J"}, {"family": "Gelmetti", "given": "Carlo", "initials": "C"}, {"family": "Szalai", "given": "Zsuzsanna", "initials": "Z"}, {"family": "Svensson", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "von Kobyletzki", "given": "Laura B", "initials": "LB"}, {"family": "De Raeve", "given": "Linda", "initials": "L"}, {"family": "F\u00f6lster-Holst", "given": "Regina", "initials": "R"}, {"family": "Christen-Zaech", "given": "St\u00e9phanie", "initials": "S"}, {"family": "Jan Hijnen", "given": "Dirk", "initials": "D"}, {"family": "Gieler", "given": "Uwe", "initials": "U"}, {"family": "Gutermuth", "given": "Jan", "initials": "J"}, {"family": "Bangert", "given": "Christine", "initials": "C"}, {"family": "Spuls", "given": "Phyllis I", "initials": "PI"}, {"family": "Kunz", "given": "Barbara", "initials": "B"}, {"family": "Ring", "given": "Johannes", "initials": "J"}, {"family": "Wollenberg", "given": "Andreas", "initials": "A"}, {"family": "Deleuran", "given": "Mette", "initials": "M"}], "type": "journal article", "published": "2021-02-15", "journal": {"title": "J Eur Acad Dermatol Venereol", "issn": "1468-3083", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic is caused by rapid spread of different strains of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The severity of infection ranges from mild, or even asymptomatic, to very severe. Signs and symptoms include fatigue, fever, exanthemas, upper respiratory illness, loss of smell and taste, pneumonia, severe acute respiratory syndrome, and multi-organ failure. Risk factors for a severe or lethal course include age, male gender, obesity, diabetes, cardiovascular disease, and immune suppression 1 .", "doi": "10.1111/jdv.17167", "pmid": "33587756", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-17T14:50:53.614Z", "modified": "2021-02-17T14:51:23.369Z"}, {"entity": "publication", "iuid": "b70af2764edf45d598cb8546b2df3aec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b70af2764edf45d598cb8546b2df3aec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b70af2764edf45d598cb8546b2df3aec"}}, "title": "Comprehensive Landscape of Heparin Therapy for COVID-19.", "authors": [{"family": "Shi", "given": "Chen", "initials": "C"}, {"family": "Tingting", "given": "Wu", "initials": "W"}, {"family": "Li", "given": "Jin-Ping", "initials": "JP"}, {"family": "Sullivan", "given": "Mitchell A", "initials": "MA"}, {"family": "Wang", "given": "Cong", "initials": "C"}, {"family": "Wang", "given": "Hanxiang", "initials": "H"}, {"family": "Deng", "given": "Bin", "initials": "B"}, {"family": "Zhang", "given": "Yu", "initials": "Y"}], "type": "journal article", "published": "2021-02-15", "journal": {"title": "Carbohydr Polym", "issn": "1879-1344", "issn-l": null, "volume": "254", "issue": null, "pages": "117232"}, "abstract": "The pandemic coronavirus disease 2019 (COVID-19), caused by the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading globally. Clinical observations found that systemic symptoms caused by SARS-CoV-2 infection are attenuated when using the anticoagulant agent heparin, indicating that heparin may play other roles in managing COVID-19, in addition to prevention of pulmonary thrombosis. Several biochemical studies show strong binding of heparin and heparin-like molecules to the Spike protein, which resulted in inhibition of viral infection to cells. The clinical observations and in vitro studies argue for a potential multiple-targeting effects of heparin. However, adverse effects of heparin administration and some of the challenges using heparin therapy for SARS-CoV-2 infection need to be considered. This review discusses the pharmacological mechanisms of heparin regarding its anticoagulant, anti-inflammatory and direct antiviral activities, providing current evidence concerning the effectiveness and safety of heparin therapy for this major public health emergency.", "doi": "10.1016/j.carbpol.2020.117232", "pmid": "33357843", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7581413"}, {"db": "pii", "key": "S0144-8617(20)31405-3"}], "notes": [], "created": "2021-01-10T17:29:41.591Z", "modified": "2023-06-19T15:36:36.473Z"}, {"entity": "publication", "iuid": "672f02017ba74c67be57dbacfb81707b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/672f02017ba74c67be57dbacfb81707b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/672f02017ba74c67be57dbacfb81707b"}}, "title": "Single-cell sequencing of plasma cells from COVID-19 patients reveals highly expanded clonal lineages produce specific and neutralizing antibodies to SARS-CoV-2", "authors": [{"family": "Ehling", "given": "Roy A", "initials": "RA"}, {"family": "Weber", "given": "C\u00e9dric R", "initials": "CR"}, {"family": "Mason", "given": "Derek M", "initials": "DM"}, {"family": "Friedensohn", "given": "Simon", "initials": "S"}, {"family": "Wagner", "given": "Bastian", "initials": "B"}, {"family": "Bieberich", "given": "Florian", "initials": "F"}, {"family": "Kapetanovic", "given": "Edo", "initials": "E"}, {"family": "Vazquez-Lombardi", "given": "Rodrigo", "initials": "R"}, {"family": "Di Roberto", "given": "Rapha\u00ebl B", "initials": "RB"}, {"family": "Hong", "given": "Kai Lin", "initials": "KL"}, {"family": "Wagner", "given": "Camille", "initials": "C"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Yermanos", "given": "Alexander", "initials": "A"}, {"family": "Cuny", "given": "Andreas P", "initials": "AP"}, {"family": "Savic", "given": "Miodrag", "initials": "M"}, {"family": "Rudolf", "given": "Fabian", "initials": "F"}, {"family": "Reddy", "given": "Sai T", "initials": "ST"}], "type": "posted-content", "published": "2021-02-12", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.12.430940", "pmid": null, "labels": {"Funder: H2020": null, "Category: Biochemistry": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-03-08T15:10:05.611Z", "modified": "2021-03-09T12:31:31.351Z"}, {"entity": "publication", "iuid": "2e8684b503454348aaab5858f9790222", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e8684b503454348aaab5858f9790222.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e8684b503454348aaab5858f9790222"}}, "title": "Quantifying the preventive effect of wearing face masks", "authors": [{"family": "Britton", "given": "Tom", "initials": "T"}], "type": "posted-content", "published": "2021-02-12", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.09.21251448", "pmid": null, "labels": {"Type: Preprint": null, "Funder: NordForsk": null, "Category: Health": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-15T18:30:28.164Z", "modified": "2021-02-26T08:46:13.012Z"}, {"entity": "publication", "iuid": "55ad8ca80a844ef99d92fc0f73089a41", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/55ad8ca80a844ef99d92fc0f73089a41.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/55ad8ca80a844ef99d92fc0f73089a41"}}, "title": "Changes in Lifestyle, Behaviors, and Risk Factors for Cognitive Impairment in Older Persons During the First Wave of the Coronavirus Disease 2019 Pandemic in Finland: Results From the FINGER Study.", "authors": [{"family": "Lehtisalo", "given": "Jenni", "initials": "J"}, {"family": "Palmer", "given": "Katie", "initials": "K"}, {"family": "Mangialasche", "given": "Francesca", "initials": "F"}, {"family": "Solomon", "given": "Alina", "initials": "A"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Ngandu", "given": "Tiia", "initials": "T"}], "type": "journal article", "published": "2021-02-12", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "issue": null, "pages": "624125", "issn-l": "1664-0640"}, "abstract": "Aims: This study aimed to describe how the first phase of the coronavirus disease 2019 (COVID-19) pandemic affected older persons from the general Finnish population who are at risk of developing or have cognitive impairment, specifically, to describe whether participants experienced a change in risk factors that are relevant for the prevention of cognitive decline including diet, physical activity, access to medical care, socially and cognitively stimulating activities, and emotional health and well-being. Method: A postal survey was sent in June 2020 to 859 participants from the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), an ongoing longitudinal study. The survey was developed to assess the effect of the COVID-19 pandemic and related infection-control measures on daily life, specifically commitment to distancing measures, access to health care and social services, daily activities, and changes in cognitive and social activities. Results: By September 2020, 613 (71%) participants responded (mean age = 77.7 years, 32% lived alone, and 80% had at least one chronic condition). Three quarters adopted some distancing practices during the first months of the pandemic. Older participants were more likely to practice total isolation than younger ones (29 vs. 19%; p = 0.003). Non-acute health-care visits were canceled for 5% of the participants who needed appointments, but cancellations in dental health care (43%), home aid (30%), and rehabilitative services (53%) were more common. Pandemic-related changes were reported in social engagements, for example, less contact with friends (55%) and family (31%), or less frequent attendance in cultural events (38%) or associations (25%), although remote contact with others increased for 40%. Feelings of loneliness increased for 21%, particularly those who were older (p = 0.023) or living alone (p < 0.001). Physical activity reduced for 34%, but dietary habits remained stable or improved. Pandemic-related changes in lifestyle and activities were more evident among those living alone. Conclusions: Finnish older persons generally reported less negative changes in lifestyles and behaviors during the pandemic than expected. Older people and those living alone seemed more susceptible to negative changes. It is important to compare how coping strategies may compare with other European countries to identify factors that may help older individuals to maintain healthy lifestyles during future waves of COVID-19.", "doi": "10.3389/fpsyt.2021.624125", "pmid": "33643095", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC7907420"}], "notes": [], "created": "2021-03-02T06:52:05.714Z", "modified": "2021-03-02T06:52:05.717Z"}, {"entity": "publication", "iuid": "d1d6dd596f3249b8bac66ef8ae32e8ec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1d6dd596f3249b8bac66ef8ae32e8ec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1d6dd596f3249b8bac66ef8ae32e8ec"}}, "title": "Tropism of SARS-CoV-2 in commonly used laboratory cell lines and their proteomic landscape during infection", "authors": [{"family": "Elisa Saccon", "given": "", "initials": ""}, {"family": "Xi Chen", "given": ".", "initials": "."}, {"family": "Flora Mikaeloff", "given": "", "initials": ""}, {"family": "jimmy Esneider Rodriguez", "given": "", "initials": ""}, {"family": "Laszlo Szekely", "given": "", "initials": ""}, {"family": "Beatriz S\u00e1 Vinhas", "given": "", "initials": ""}, {"family": "shuba Krishnan", "given": "", "initials": ""}, {"family": "Siddappa N. Byrareddy", "given": "", "initials": ""}, {"family": "Teresa Frisan", "given": "", "initials": ""}, {"family": "\u00c1kos V\u00e9gv\u00e1ri", "given": "", "initials": ""}, {"family": "Ali Mirazimi", "given": "UM", "initials": "U"}, {"family": "ujjwal Neogi", "given": "", "initials": ""}, {"family": "Gupta", "given": "Soham", "initials": "S"}], "type": "posted-content", "published": "2021-02-11", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.08.28.271684", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-02-11T15:56:44.718Z", "modified": "2021-04-23T15:15:50.301Z"}, {"entity": "publication", "iuid": "b335292c5a9a433691ef0b36bf1a765b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b335292c5a9a433691ef0b36bf1a765b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b335292c5a9a433691ef0b36bf1a765b"}}, "title": "Mechanistic and Therapeutic Implications of Extracellular Vesicles as a Potential Link Between Covid-19 and Cardiovascular Disease Manifestations.", "authors": [{"family": "Pironti", "given": "Gianluigi", "initials": "G"}, {"family": "Andersson", "given": "Daniel C", "initials": "DC"}, {"family": "Lund", "given": "Lars H", "initials": "LH"}], "type": "journal article", "published": "2021-02-11", "journal": {"title": "Front Cell Dev Biol", "issn": "2296-634X", "issn-l": null, "volume": "9", "issue": null, "pages": "640723"}, "abstract": "Extracellular vesicles (EVs), which are cell released double layered membrane particles, have been found in every circulating body fluid, and provide a tool for conveying diverse information between cells, influencing both physiological and pathological conditions. Viruses can hijack the EVs secretory pathway to exit infected cells and use EVs endocytic routes to enter uninfected cells, suggesting that EVs and viruses can share common cell entry and biogenesis mechanisms. SARS-CoV-2 is responsible of the coronavirus disease 2019 (Covid-19), which may be accompanied by severe multi-organ manifestations. EVs may contribute to virus spreading via transfer of virus docking receptors such as CD9 and ACE2. Covid-19 is known to affect the renin angiotensin system (RAS), and could promote secretion of harmful EVs. In this scenario EVs might be linked to cardiovascular manifestations of the Covid-19 disease through unbalance in RAS. In contrast EVs derived from mesenchymal stem cells or cardiosphere derived cells, may promote cardiovascular function due to their beneficial effect on angiogenesis, fibrosis, contractility and immuno-modulation. In this article we assessed the potential impact of EVs in cardiovascular manifestations of Covid-19 and highlight potential strategies to control the extracellular signaling for future therapies.", "doi": "10.3389/fcell.2021.640723", "pmid": "33644077", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7905102"}], "notes": [], "created": "2021-03-02T06:55:09.771Z", "modified": "2021-06-18T11:56:14.114Z"}, {"entity": "publication", "iuid": "7f57776f36ed41deb09c507dede3348d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f57776f36ed41deb09c507dede3348d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f57776f36ed41deb09c507dede3348d"}}, "title": "Is There an Effect of Fetal Mesenchymal Stem Cells in the Mother-Fetus Dyad in COVID-19 Pregnancies and Vertical Transmission?", "authors": [{"family": "Samara", "given": "Athina", "initials": "A"}, {"family": "Herlenius", "given": "Eric", "initials": "E"}], "type": "journal article", "published": "2021-02-11", "journal": {"title": "Front Physiol", "issn": "1664-042X", "issn-l": null, "volume": "11", "issue": null, "pages": "624625"}, "abstract": "Because of the polysystemic nature of coronavirus disease 2019 (COVID-19), during the present pandemic, there have been serious concerns regarding pregnancy, vertical transmission, and intrapartum risk. The majority of pregnant patients with COVID-19 infection present with mild or asymptomatic course of the disease. Some cases were hospitalized, and few needed intensive care unit admission, or mechanical ventilation. There have also been scarce case reports where neonates required mechanical ventilation post COVID-19 pregnancies. Without approved therapies other than dexamethasone, advanced mesenchymal cell therapy is one immunomodulatory therapeutic approach that is currently explored and might hold great promise. We suggest that the circulating fetal stem cells might have an immune-protective effect to mothers and contribute to the often mild and even asymptomatic post-COVID-19 pregnancies. Thus, COVID-19 pregnancies come forth as a paradigm to be further and more comprehensively approached, to understand both the mechanism and action of circulating stem cells in immunoprotection and hypoxia in microcirculation.", "doi": "10.3389/fphys.2020.624625", "pmid": "33679426", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7928412"}], "notes": [], "created": "2021-03-09T15:33:16.053Z", "modified": "2021-06-18T12:01:22.813Z"}, {"entity": "publication", "iuid": "4b706f8c6b6a4c2baefaf1e4c62560ed", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b706f8c6b6a4c2baefaf1e4c62560ed.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b706f8c6b6a4c2baefaf1e4c62560ed"}}, "title": "Dehumanization During the COVID-19 Pandemic", "authors": [{"family": "Markowitz", "given": "David M", "initials": "DM"}, {"family": "Shoots-Reinhard", "given": "Brittany", "initials": "B"}, {"family": "Peters", "given": "Ellen", "initials": "E"}, {"family": "Silverstein", "given": "Michael C", "initials": "MC"}, {"family": "Goodwin", "given": "Raleigh", "initials": "R"}, {"family": "Bj\u00e4lkebring", "given": "P\u00e4r", "initials": "P"}], "type": "journal-article", "published": "2021-02-11", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "issue": null, "pages": null, "issn-l": "1664-1078"}, "abstract": null, "doi": "10.3389/fpsyg.2021.634543", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-03-02T06:56:54.710Z", "modified": "2021-03-02T06:56:54.720Z"}, {"entity": "publication", "iuid": "4bd12053e8924d3fb6fa414fa0c63638", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4bd12053e8924d3fb6fa414fa0c63638.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4bd12053e8924d3fb6fa414fa0c63638"}}, "title": "Problematic internet-related behaviors mediate the associations between levels of internet engagement and distress among schoolchildren during COVID-19 lockdown: A longitudinal structural equation modeling study.", "authors": [{"family": "Chen", "given": "I-Hua", "initials": "I"}, {"family": "Chen", "given": "Chao-Ying", "initials": "C"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Li", "given": "Xu-Dong", "initials": "X"}, {"family": "Tsang", "given": "Hector W H", "initials": "HWH"}], "type": "journal article", "published": "2021-02-10", "journal": {"title": "J Behav Addict", "issn": "2063-5303", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Due to the rapid spread of the novel coronavirus disease 2019 (COVID-19), policies based on the nature of \"spatial distancing\" have been implemented and have resulted in school suspensions and online learning among schoolchildren. In order to examine the impact of such policies on schoolchildren, the aims of the present study were to (i) assess changes in the level of engagement in three internet-related activities (smartphone use, social media use, and gaming) before and during the COVID-19 outbreak, including prolonged and problematic engagement in these activities; (ii) investigate the differences of psychological distress before and after COVID-19 outbreak; and (iii) to use structural equation modeling to investigate the mediating roles of problematic internet-related behaviors in the causal relationships of psychological distress and time spent on internet-related activities.\r\n\r\nSelf-report measures were used to assess internet-related activities and psychological distress. Time spent on internet-related activities, problematic use of internet-related activities, and psychological distress were collected from primary school students (N = 535; 265 boys; M age = 10.32 years [SD = 0.84]). The data were first collected before the COVID-19 outbreak (i.e., early November 2019) and then collected again during the school suspension due to COVID-19 outbreak (i.e., end of March 2020) for comparisons of changes.\r\n\r\nSchoolchildren spent significantly more time on the smartphone (increased 1.02 h daily; P < 0.001) and social media (increased 0.73 h daily; P < 0.001) but not gaming (increased 0.14 h daily; P = 0.07) during the school suspension compared to the baseline. Schoolchildren who increased by 15 or 30 min daily on internet-related activities showed an increased level of psychological distress. The association between problematic use of social media and psychological distress was stronger during the school suspension (\u03b2 = 0.584) than at the baseline (\u03b2 = 0.451; P < 0.001).\r\n\r\nIncreased problematic use of internet-related activities among schoolchildren was associated with greater psychological distress. Parents should therefore monitor internet-related activities and psychological distress of their children to support their mental health.", "doi": "10.1556/2006.2021.00006", "pmid": "33570506", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-15T17:33:28.219Z", "modified": "2021-06-18T12:07:46.281Z"}, {"entity": "publication", "iuid": "2b523eff6797470a962feeedf8b57d7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b523eff6797470a962feeedf8b57d7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b523eff6797470a962feeedf8b57d7e"}}, "title": "Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19.", "authors": [{"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Czarlewski", "given": "Wienczyslawa", "initials": "W"}, {"family": "Zuberbier", "given": "Torsten", "initials": "T"}, {"family": "Mullol", "given": "Joaquim", "initials": "J"}, {"family": "Blain", "given": "Hubert", "initials": "H"}, {"family": "Cristol", "given": "Jean-Paul", "initials": "JP"}, {"family": "De La Torre", "given": "Rafael", "initials": "R"}, {"family": "Pizarro Lozano", "given": "Nieves", "initials": "N"}, {"family": "Le Moing", "given": "Vincent", "initials": "V"}, {"family": "Bedbrook", "given": "Anna", "initials": "A"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Akdis", "given": "Cezmi A", "initials": "CA"}, {"family": "Canonica", "given": "G Walter", "initials": "GW"}, {"family": "Cruz", "given": "Alvaro A", "initials": "AA"}, {"family": "Fiocchi", "given": "Alessandro", "initials": "A"}, {"family": "Fonseca", "given": "Joao A", "initials": "JA"}, {"family": "Fonseca", "given": "Susana", "initials": "S"}, {"family": "Gemicio\u011flu", "given": "Bilun", "initials": "B"}, {"family": "Haahtela", "given": "Tari", "initials": "T"}, {"family": "Iaccarino", "given": "Guido", "initials": "G"}, {"family": "Ivancevich", "given": "Juan Carlos", "initials": "JC"}, {"family": "Jutel", "given": "Marek", "initials": "M"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Kraxner", "given": "Helga", "initials": "H"}, {"family": "Kuna", "given": "Piotr", "initials": "P"}, {"family": "Larenas-Linnemann", "given": "D\u00e9sir\u00e9e E", "initials": "DE"}, {"family": "Martineau", "given": "Adrian", "initials": "A"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Okamoto", "given": "Yoshitaka", "initials": "Y"}, {"family": "Papadopoulos", "given": "Nikolaos G", "initials": "NG"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Regateiro", "given": "Frederico S", "initials": "FS"}, {"family": "Reynes", "given": "Jacques", "initials": "J"}, {"family": "Rolland", "given": "Yves", "initials": "Y"}, {"family": "Rouadi", "given": "Philip W", "initials": "PW"}, {"family": "Samolinski", "given": "Boleslaw", "initials": "B"}, {"family": "Sheikh", "given": "Aziz", "initials": "A"}, {"family": "Toppila-Salmi", "given": "Sanna", "initials": "S"}, {"family": "Valiulis", "given": "Arunas", "initials": "A"}, {"family": "Choi", "given": "Hak-Jong", "initials": "HJ"}, {"family": "Kim", "given": "Hyun Ju", "initials": "HJ"}, {"family": "Anto", "given": "Josep M", "initials": "JM"}], "type": "journal article", "published": "2021-02-10", "journal": {"title": "Int Arch Allergy Immunol", "issn": "1018-2438", "volume": null, "issue": null, "pages": "1-15", "issn-l": null}, "abstract": "In this article, we propose that differences in COVID-19 morbidity may be associated with transient receptor potential ankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 (TRPV1) activation as well as desensitization. TRPA1 and TRPV1 induce inflammation and play a key role in the physiology of almost all organs. They may augment sensory or vagal nerve discharges to evoke pain and several symptoms of COVID-19, including cough, nasal obstruction, vomiting, diarrhea, and, at least partly, sudden and severe loss of smell and taste. TRPA1 can be activated by reactive oxygen species and may therefore be up-regulated in COVID-19. TRPA1 and TRPV1 channels can be activated by pungent compounds including many nuclear factor (erythroid-derived 2) (Nrf2)-interacting foods leading to channel desensitization. Interactions between Nrf2-associated nutrients and TRPA1/TRPV1 may be partly responsible for the severity of some of the COVID-19 symptoms. The regulation by Nrf2 of TRPA1/TRPV1 is still unclear, but suggested from very limited clinical evidence. In COVID-19, it is proposed that rapid desensitization of TRAP1/TRPV1 by some ingredients in foods could reduce symptom severity and provide new therapeutic strategies.", "doi": "10.1159/000514204", "pmid": "33567446", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "000514204"}], "notes": [], "created": "2021-02-11T15:22:39.327Z", "modified": "2021-02-11T15:22:39.344Z"}, {"entity": "publication", "iuid": "d0fae14071314e24ad54e8a7ccb1440a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d0fae14071314e24ad54e8a7ccb1440a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d0fae14071314e24ad54e8a7ccb1440a"}}, "title": "Community health worker knowledge, attitudes and practices towards COVID-19: Learnings from an online cross-sectional survey using a digital health platform, UpSCALE, in Mozambique.", "authors": [{"family": "Feldman", "given": "Mitra", "initials": "M"}, {"family": "Lacey Krylova", "given": "Vera", "initials": "V"}, {"family": "Farrow", "given": "Poppy", "initials": "P"}, {"family": "Donovan", "given": "Laura", "initials": "L"}, {"family": "Zandamela", "given": "Edson", "initials": "E"}, {"family": "Rebelo", "given": "Joaquim", "initials": "J"}, {"family": "Rodrigues", "given": "Maria", "initials": "M"}, {"family": "Bulo", "given": "Antonio", "initials": "A"}, {"family": "Ferraz", "given": "Carlos", "initials": "C"}, {"family": "Rodrigues", "given": "Humberto", "initials": "H"}, {"family": "Roca-Feltrer", "given": "Arantxa", "initials": "A"}, {"family": "Baker", "given": "Kevin", "initials": "K"}], "type": "journal article", "published": "2021-02-10", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "2", "pages": "e0244924"}, "abstract": "Healthcare workers (HCWs) are at the frontline of the Coronavirus Disease 2019 (COVID-19) pandemic response, yet there is a paucity of literature on their knowledge, attitudes and practices (KAP) in relation to the pandemic. Community Health Workers (CHWs) in Mozambique are known locally as agentes polivalentes elementares (APEs). While technical guidance surrounding COVID-19 is available to support APEs, communicating this information has been challenging due to restrictions on travel, face-to-face group meetings and training, imposed from May to August 2020. A digital health platform, upSCALE, that already supports 1,213 APEs and 299 supervisors across three provinces, is being used to support APEs on effective COVID-19 management by delivering COVID-19 sensitive SMS messages, training modules and a COVID-19 KAP survey. The KAP survey, conducted from June 2020 to August 2020, consisted of 10 questions. Of 1,065 active upSCALE APEs, 28% completed the survey. Results indicate that only a small proportion of APEs listed the correct COVID-19 symptoms, transmission routes and appropriate prevention measures (n = (25%), n = (16%) and n = (39%), respectively) specifically included in national health education materials. Misconceptions were mainly related to transmission routes, high risk individuals and asymptomatic patients. 84% said they followed all government prevention guidelines. The results from the KAP survey were used to support the rapid development and deployment of targeted COVID-19 awareness and education materials for the APEs. A follow-up KAP survey is planned for November 2020. Adapting the existing upSCALE platform enabled a better understanding, in real time, of the KAP of APEs around COVID-19 management. Subsequently, supporting delivery of tailored messages and education, vital for ensuring a successful COVID-19 response.", "doi": "10.1371/journal.pone.0244924", "pmid": "33566850", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-32538"}, {"db": "URL", "key": "https://reshare.ukdataservice.ac.uk/854605/", "description": "The Covid-19 pandemic: knowledge, attitudes and practice among healthcare workers in Mozambique, Survey 1, 2020"}], "notes": [], "created": "2021-02-11T15:23:36.305Z", "modified": "2021-06-18T12:05:11.207Z"}, {"entity": "publication", "iuid": "badb217a9cb84081b47447b503898d2f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/badb217a9cb84081b47447b503898d2f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/badb217a9cb84081b47447b503898d2f"}}, "title": "Anticoagulation therapy in non-valvular atrial fibrillation in the COVID-19 era: is it time to reconsider our therapeutic strategy?", "authors": [{"family": "Papakonstantinou", "given": "Panteleimon E", "initials": "PE"}, {"family": "Borovac", "given": "Josip A", "initials": "JA"}, {"family": "G\u0105secka", "given": "Aleksandra", "initials": "A"}, {"family": "Bongiovanni", "given": "Dario", "initials": "D"}, {"family": "Ehrlinder", "given": "Hanne", "initials": "H"}, {"family": "Giustozzi", "given": "Michela", "initials": "M"}, {"family": "Parker", "given": "William A E", "initials": "WAE"}, {"family": "Guerreiro", "given": "Rui Azevedo", "initials": "RA"}], "type": "journal article", "published": "2021-02-10", "journal": {"title": "Eur J Prev Cardiol", "issn": "2047-4881", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1093/eurjpc/zwab021", "pmid": "33564838", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "6132124"}, {"db": "pmc", "key": "PMC7928961"}], "notes": [], "created": "2021-02-10T18:57:47.004Z", "modified": "2021-07-14T07:51:54.412Z"}, {"entity": "publication", "iuid": "f04b983482764324aa721d7822f04bc1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f04b983482764324aa721d7822f04bc1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f04b983482764324aa721d7822f04bc1"}}, "title": "A Case Series on Critically Ill Pregnant or Newly Delivered Patients with Covid-19, Treated at Karolinska University Hospital, Stockholm", "authors": [{"family": "Polcer", "given": "Rasha El ahmad", "initials": "REa"}, {"family": "Jones", "given": "Elin", "initials": "E"}, {"family": "Pettersson", "given": "Karin", "initials": "K"}], "type": "journal-article", "published": "2021-02-10", "journal": {"title": "Case Reports in Obstetrics and Gynecology", "issn": "2090-6692", "issn-l": null, "volume": "2021", "issue": null, "pages": "1-7"}, "abstract": "In this retrospective report, we present five cases of critically ill pregnant or newly delivered women positive for Covid-19 admitted to our obstetrical departments at Karolinska University Hospital. They compose 6% of eighty-three pregnant women that tested positive for SARS-CoV-2 during the period March 25 to May 4, 2020. Three patients were at the time of admission in gestational week between 21 + 4 and 22 + 5 and treated during their antenatal period; meanwhile, the other two were admitted within 1 week postpartum. All of them were in need of intensive care: one was treated with high flow oxygen therapy, the other four with invasive mechanical ventilation (three with endotracheal intubation and one with extracorporeal membrane oxygenation). Age above thirty, overweight, and gestational diabetes are notable factors in the cases presented. At the time of admission, they all presented with symptoms such as fever, cough, and dyspnea. Chest imaging with computer tomography scan was performed in each case and demonstrated multifocal pneumonic infiltrates in all of them, but no pulmonary embolism was confirmed in any. Neither did the echocardiogram indicate any cardiomyopathy. Four of the patients have been discharged from the hospital, with an average of 20 hospital days. One antenatal pregnant woman needed prolonged ECMO therapy; in gestational week 27 + 3, she went into cardiac arrest, resulting in an urgent C-section on maternal indication. At the time of writing, she is still hospitalized. In coherence with other published reports, our cases indicate that critically ill pregnant women infected by SARS-Cov-2 may develop severe respiratory distress syndrome requiring prolonged intensive care. The material is limited for conclusions to be made; more detailed information on symptoms, treatment, and outcomes for pregnant and postpartum women managed in intensive care is therefore needed.", "doi": "10.1155/2021/8868822", "pmid": "33628548", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-25T12:31:56.276Z", "modified": "2021-06-18T11:42:21.196Z"}, {"entity": "publication", "iuid": "77f938e81f1d4b39b6265fbea9bfe0b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/77f938e81f1d4b39b6265fbea9bfe0b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/77f938e81f1d4b39b6265fbea9bfe0b2"}}, "title": "\"People play it down and tell me it can't kill people, but I know people are dying each day\". Children's health literacy relating to a global pandemic (COVID-19); an international cross sectional study.", "authors": [{"family": "Bray", "given": "Lucy", "initials": "L"}, {"family": "Carter", "given": "Bernie", "initials": "B"}, {"family": "Blake", "given": "Lucy", "initials": "L"}, {"family": "Saron", "given": "Holly", "initials": "H"}, {"family": "Kirton", "given": "Jennifer A", "initials": "JA"}, {"family": "Robichaud", "given": "Fanny", "initials": "F"}, {"family": "Avila", "given": "Marla", "initials": "M"}, {"family": "Ford", "given": "Karen", "initials": "K"}, {"family": "Nafria", "given": "Begonya", "initials": "B"}, {"family": "Forsner", "given": "Maria", "initials": "M"}, {"family": "Nilsson", "given": "Stefan", "initials": "S"}, {"family": "Chelkowski", "given": "Andrea", "initials": "A"}, {"family": "Middleton", "given": "Andrea", "initials": "A"}, {"family": "Rullander", "given": "Anna-Clara", "initials": "A"}, {"family": "Mattsson", "given": "Janet", "initials": "J"}, {"family": "Protheroe", "given": "Joanne", "initials": "J"}], "type": "journal article", "published": "2021-02-10", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "2", "pages": "e0246405"}, "abstract": "The aim of this study was to examine aspects of children's health literacy; the information sources they were accessing, their information preferences, their perceived understanding of and their reported information needs in relation to COVID-19. An online survey for children aged 7-12 years of age and parent/caregivers from the UK, Sweden, Brazil, Spain, Canada and Australia was conducted between 6th of April and the 1st of June 2020. The surveys included demographic questions and both closed and open questions focussing on access to and understanding of COVID-19 information. Descriptive statistics and qualitative content analysis procedures were conducted. The findings show that parents are the main source of information for children during the pandemic in most countries (89%, n = 347), except in Sweden where school was the main source of information. However, in many cases parents chose to shield, filter or adapt their child's access to information about COVID-19, especially in relation to the death rates within each country. Despite this, children in this study reported knowing that COVID-19 was deadly and spreads quickly. This paper argues for a community rather than individual approach to addressing children's health literacy needs during a pandemic.", "doi": "10.1371/journal.pone.0246405", "pmid": "33566813", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-19761"}], "notes": [], "created": "2021-02-11T15:29:29.582Z", "modified": "2021-06-18T12:06:38.023Z"}, {"entity": "publication", "iuid": "7278e8eb255248eb836f6d82888ae39c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7278e8eb255248eb836f6d82888ae39c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7278e8eb255248eb836f6d82888ae39c"}}, "title": "The development of preprints during the COVID-19 pandemic.", "authors": [{"family": "\u00c4lg\u00e5", "given": "Andreas", "initials": "A"}, {"family": "Eriksson", "given": "Oskar", "initials": "O"}, {"family": "Nordberg", "given": "Martin", "initials": "M"}], "type": "editorial", "published": "2021-02-09", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1111/joim.13240", "pmid": "33560546", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-10T18:59:52.815Z", "modified": "2021-02-10T18:59:52.826Z"}, {"entity": "publication", "iuid": "536b0c5204ee49c280d9f4d8249a56a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/536b0c5204ee49c280d9f4d8249a56a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/536b0c5204ee49c280d9f4d8249a56a2"}}, "title": "Sustained prothrombotic changes in COVID-19 patients 4 months after hospital discharge.", "authors": [{"family": "von Meijenfeldt", "given": "Fien A", "initials": "FA"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Adelmeijer", "given": "Jelle", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Thalin", "given": "Charlotte", "initials": "C"}, {"family": "Lisman", "given": "Ton", "initials": "T"}], "type": "journal article", "published": "2021-02-09", "journal": {"title": "Blood Adv", "issn": "2473-9537", "issn-l": null, "volume": "5", "issue": "3", "pages": "756-759"}, "abstract": null, "doi": "10.1182/bloodadvances.2020003968", "pmid": "33560386", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "475081"}], "notes": [], "created": "2021-02-10T18:46:05.850Z", "modified": "2021-06-11T14:26:07.518Z"}, {"entity": "publication", "iuid": "2b9f338fa3e240a480a9162feedee0b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b9f338fa3e240a480a9162feedee0b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b9f338fa3e240a480a9162feedee0b9"}}, "title": "Handwashing with soap: A concern for overuse of water amidst the COVID-19 pandemic in Bangladesh.", "authors": [{"family": "Sayeed", "given": "Abu", "initials": "A"}, {"family": "Rahman", "given": "Md Hafizur", "initials": "MH"}, {"family": "Bundschuh", "given": "Jochen", "initials": "J"}, {"family": "Herath", "given": "Indika", "initials": "I"}, {"family": "Ahmed", "given": "Fahad", "initials": "F"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Tariq", "given": "Mohammad Raihan", "initials": "MR"}, {"family": "Rahman", "given": "Faujhia", "initials": "F"}, {"family": "Tarikul Islam Joy", "given": "Md", "initials": "M"}, {"family": "Tazrian Abid", "given": "Mohammad", "initials": "M"}, {"family": "Saha", "given": "Nondo", "initials": "N"}, {"family": "Hasan", "given": "M Tasdik", "initials": "MT"}], "type": "journal article", "published": "2021-02-09", "journal": {"title": "Groundw Sustain Dev", "issn": "2352-801X", "volume": "13", "issue": null, "pages": "100561", "issn-l": null}, "abstract": "Handwashing is one of the vital public health measures. It helps to prevent the spread of the COVID-19 pandemic. However, water overuse during hand scrubbing with soap keeping the tap on may put enormous pressure on the already overstretched groundwater resources and households' economic well-being. Therefore, this study aimed to determine the overuse of water while scrubbing hands with soap for handwashing when the tap is on amid the COVID-19 pandemic in Bangladesh. Sociodemographic data were collected using a web-based survey tool among 1980 participants and an experiment was conducted among 126 participants to estimate the overuse of water during hand scrubbing while the tap is on. A total of 80% of the participants washed their hands regularly after returning home from outside. About 57.27% of participants did not turn off their tap throughout the handwashing process. A single participant, who kept his tap on throughout the handwashing process, overused approximately 1.7L of water per handwash and 14.9L of water per day. Hand scrubbing with soap keeping the tap on, raised the overuse of water 13-fold during this pandemic compared to the non-pandemic situation which cost an extra 224.95 BDT (2.65$) per day for 1980 participants. Minimize the speed of tap, using automatic taps, and using taps operated by legs might be an effective solution to reduce the water overuse. Furthermore, behavioral change interventions are needed to aware people turn off the tap during hand scrubbing with soap.", "doi": "10.1016/j.gsd.2021.100561", "pmid": "33585670", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2352-801X(21)00017-5"}, {"db": "pmc", "key": "PMC7871103"}], "notes": [], "created": "2021-02-17T14:50:24.246Z", "modified": "2021-03-22T11:42:49.287Z"}, {"entity": "publication", "iuid": "e562fc74663e4915acbb53b5738d65a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e562fc74663e4915acbb53b5738d65a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e562fc74663e4915acbb53b5738d65a4"}}, "title": "First detection of SARS-CoV-2 genetic material in the vicinity of COVID-19 isolation Centre in Bangladesh: Variation along the sewer network.", "authors": [{"family": "Ahmed", "given": "Firoz", "initials": "F"}, {"family": "Islam", "given": "Md Aminul", "initials": "MA"}, {"family": "Kumar", "given": "Manish", "initials": "M"}, {"family": "Hossain", "given": "Maqsud", "initials": "M"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Islam", "given": "Md Tahmidul", "initials": "MT"}, {"family": "Hossen", "given": "Foysal", "initials": "F"}, {"family": "Hossain", "given": "Md Shahadat", "initials": "MS"}, {"family": "Islam", "given": "Md Sydul", "initials": "MS"}, {"family": "Uddin", "given": "Md Main", "initials": "MM"}, {"family": "Islam", "given": "Md Nur", "initials": "MN"}, {"family": "Bahadur", "given": "Newaz Mohammed", "initials": "NM"}, {"family": "Didar-Ul-Alam", "given": "Md", "initials": "M"}, {"family": "Reza", "given": "Hasan Mahmud", "initials": "HM"}, {"family": "Jakariya", "given": "Md", "initials": "M"}], "type": "journal article", "published": "2021-02-09", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "volume": "776", "issue": null, "pages": "145724", "issn-l": "0048-9697"}, "abstract": "We made the first and successful attempt to detect SARS-CoV-2 genetic material in the vicinity wastewaters of an isolation centre i.e. Shaheed Bhulu Stadium, situated at Noakhali, Southeastern Bangladesh. Owing to the fact that isolation centre, in general, always contained a constant number of 200 COVID-19 patients, the prime objective of the study was to check if several drains carrying RNA of coronavirus are actually getting diluted or accumulated along with the sewage network. Our finding suggested that while the temporal variation of the genetic load decreased in small drains over the span of 50 days, the main sewer exhibited accumulation of SARS-CoV-2 RNA. Other interesting finding displays that probably distance of sampling location in meters is not likely to have a significant impact on the detected gene concentration, although the quantity of the RNA extracted in the downstream of the drain was higher. These findings are of immense value from the perspective of wastewater surveillance of COVID-19, as they largely imply that we do not need to monitor every wastewater system, and probably major drains monitoring may illustrate the city health. Perhaps, we are reporting the accumulation of SARS-CoV-2 genetic material along with the sewer network i.e. from primary to tertiary drains. The study sought further data collection in this line to simulate conditions prevailed in most of the developing countries and to shed further light on decay/accumulation processes of the genetic load of the SARS-COV-2.", "doi": "10.1016/j.scitotenv.2021.145724", "pmid": "33652314", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(21)00791-9"}], "notes": [], "created": "2021-03-03T17:01:46.916Z", "modified": "2021-03-03T17:01:46.926Z"}, {"entity": "publication", "iuid": "b9bc34b1d45246a19d2d3aff1df7c606", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9bc34b1d45246a19d2d3aff1df7c606.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9bc34b1d45246a19d2d3aff1df7c606"}}, "title": "COVID-19 vaccines and kidney disease.", "authors": [{"family": "Windpessl", "given": "Martin", "initials": "M"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Anders", "given": "Hans-Joachim", "initials": "HJ"}, {"family": "Kramer", "given": "Holly", "initials": "H"}, {"family": "Waldman", "given": "Meryl", "initials": "M"}, {"family": "Renia", "given": "Laurent", "initials": "L"}, {"family": "Ng", "given": "Lisa F P", "initials": "LFP"}, {"family": "Xing", "given": "Zhou", "initials": "Z"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2021-02-08", "journal": {"title": "Nat Rev Nephrol", "issn": "1759-507X", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1038/s41581-021-00406-6", "pmid": "33558753", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41581-021-00406-6"}], "notes": [], "created": "2021-02-10T18:47:05.964Z", "modified": "2021-02-10T18:47:05.975Z"}, {"entity": "publication", "iuid": "57df1c32e6104e6b9634fabdc4d27b9b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/57df1c32e6104e6b9634fabdc4d27b9b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/57df1c32e6104e6b9634fabdc4d27b9b"}}, "title": "Studying Gambling Behaviors and Responsible Gambling Tools in a Simulated Online Casino Integrated With Amazon Mechanical Turk: Development and Initial Validation of Survey Data and Platform Mechanics of the Frescati Online Research Casino", "authors": [{"family": "Lindner", "given": "Philip", "initials": "P"}, {"family": "Ramner\u00f6", "given": "Jonas", "initials": "J"}, {"family": "Ivanova", "given": "Ekaterina", "initials": "E"}, {"family": "Carlbring", "given": "Per", "initials": "P"}], "type": "journal-article", "published": "2021-02-05", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "issn-l": "1664-0640", "volume": "11", "issue": null, "pages": null}, "abstract": null, "doi": "10.3389/fpsyt.2020.571954", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-22T14:07:06.763Z", "modified": "2021-02-26T08:46:59.959Z"}, {"entity": "publication", "iuid": "cfe8ca6f92bd43ca9beba7c1fd0ed82b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfe8ca6f92bd43ca9beba7c1fd0ed82b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfe8ca6f92bd43ca9beba7c1fd0ed82b"}}, "title": "Family Transmission of COVID-19 Including a Child with MIS-C and Acute Pancreatitis.", "authors": [{"family": "Abbas", "given": "Maher", "initials": "M"}, {"family": "T\u00f6rnhage", "given": "Carl-Johan", "initials": "C"}], "type": "case reports", "published": "2021-02-05", "journal": {"title": "Int Med Case Rep J", "issn": "1179-142X", "issn-l": null, "volume": "14", "issue": null, "pages": "55-65"}, "abstract": "Spread of the novel coronavirus SARS-CoV-2, since at least December 2019, has caused a pandemic. SARS-CoV-2 causes the disease COVID-19, which can affect several human organs. Abdominal pain is one of the known symptoms, but little is known about acute pancreatitis as a complication. As well, knowledge about viral transmission in families is limited. This case report describes MIS-C and acalculous acute pancreatitis in a child who was a member of a family in which four of five members had COVID-19.\r\n\r\nA previously healthy family was infected by SARS-CoV-2 from an unknown source. The 13-year-old daughter was infected by SARS-CoV-2 and symptomatic during two periods, with an asymptomatic interval in-between. During the first period, she had transient and mild upper respiratory symptoms which was followed four weeks later by a secondary severe illness. At that point, there was inflammation in multiple organs and signs of Multisystem Inflammatory Syndrome in Children (MIS-C) and a Kawasaki-like disease with skin rash, scalded skin in hands and conjunctivitis. Myocarditis, bronchopneumonia, pancreatitis, and hepatopathy without encephalopathy were noted. She required assisted ventilation for 5 days. There were laboratory signs of disseminated intravascular coagulopathy. The multisystem inflammation was treated with intravenous immunoglobulin (IVIG) once a day for four days and immunotherapy (high dose methylprednisolone (IV) once a day, for 12 days, then tapered over 4 weeks, anakinra (IV) four times daily for 12 days), low molecular weight heparin for 22 days and salicylates for 6 weeks leading to full restoration of health. The two brothers and mother in the family had mild to moderate COVID-19 infections. The father was not affected despite close contact with his children. The household transmission and clinical course and outcome are described. No further known COVID-19 infection occurred in the neighborhood during or immediately after the family cluster was discovered.\r\n\r\nPenetrance and severity of COVID-19 can vary in family clusters. One adolescent showed a two-phase course with severe infection. This case report highlights MIS-C and acute pancreatitis as a complication associated with COVID-19 in children.", "doi": "10.2147/IMCRJ.S284480", "pmid": "33574714", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "284480"}, {"db": "pmc", "key": "PMC7872935"}], "notes": [], "created": "2021-02-15T12:55:45.375Z", "modified": "2021-06-18T11:40:22.589Z"}, {"entity": "publication", "iuid": "b4d9a71a5e6d4e88930986beffc8b7d8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b4d9a71a5e6d4e88930986beffc8b7d8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b4d9a71a5e6d4e88930986beffc8b7d8"}}, "title": "Efficacy and tolerability of bevacizumab in patients with severe Covid-19.", "authors": [{"family": "Pang", "given": "Jiaojiao", "initials": "J", "orcid": "0000-0003-0072-3703", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb34db1aeb5f4f2391db995b579ea6ea.json"}}, {"family": "Xu", "given": "Feng", "initials": "F", "orcid": "0000-0002-4670-3727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/498adee7663c41338b60b0b778220c74.json"}}, {"family": "Aondio", "given": "Gianmarco", "initials": "G"}, {"family": "Li", "given": "Yu", "initials": "Y", "orcid": "0000-0003-4798-1638", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4f22daad666482fa488f4ce3e61d529.json"}}, {"family": "Fumagalli", "given": "Alberto", "initials": "A", "orcid": "0000-0002-7126-2337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d45660687d943c692306180fa66ab53.json"}}, {"family": "Lu", "given": "Ming", "initials": "M", "orcid": "0000-0002-8685-6322", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fce9ebd8f3c04405b9f596909fd01d16.json"}}, {"family": "Valmadre", "given": "Giuseppe", "initials": "G"}, {"family": "Wei", "given": "Jie", "initials": "J"}, {"family": "Bian", "given": "Yuan", "initials": "Y", "orcid": "0000-0001-8559-2575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/756cab44ecb54bb9a627776894d99981.json"}}, {"family": "Canesi", "given": "Margherita", "initials": "M"}, {"family": "Damiani", "given": "Giovanni", "initials": "G", "orcid": "0000-0003-1736-9480", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00a2feef9a8a4fd28bd5edb74ab4935d.json"}}, {"family": "Zhang", "given": "Yuan", "initials": "Y", "orcid": "0000-0003-1052-2286", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab7225c5de0247e8b675a1099dae61b2.json"}}, {"family": "Yu", "given": "Dexin", "initials": "D", "orcid": "0000-0001-7462-3153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/febf345d28374bf49009cb2a2d0cd5b8.json"}}, {"family": "Chen", "given": "Jun", "initials": "J", "orcid": "0000-0002-4865-9977", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad80138669a240f8bd11e1502ba55539.json"}}, {"family": "Ji", "given": "Xiang", "initials": "X"}, {"family": "Sui", "given": "Wenhai", "initials": "W", "orcid": "0000-0001-6114-0443", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79e84ee2d66c4463a20ced8545e4f7c1.json"}}, {"family": "Wang", "given": "Bailu", "initials": "B", "orcid": "0000-0002-5420-9569", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceefa93c6e3e4f2fb606d20435630b3c.json"}}, {"family": "Wu", "given": "Shuo", "initials": "S", "orcid": "0000-0003-3684-4363", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/502c977738674afc94abc7866b5acb65.json"}}, {"family": "Kovacs", "given": "Attila", "initials": "A"}, {"family": "Revera", "given": "Miriam", "initials": "M"}, {"family": "Wang", "given": "Hao", "initials": "H", "orcid": "0000-0003-4493-3147", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4fdb7f4d1b04a5dae7c2ce062117149.json"}}, {"family": "Jing", "given": "Xu", "initials": "X"}, {"family": "Zhang", "given": "Ying", "initials": "Y", "orcid": "0000-0003-1052-2286", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab7225c5de0247e8b675a1099dae61b2.json"}}, {"family": "Chen", "given": "Yuguo", "initials": "Y", "orcid": "0000-0001-9501-2546", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2960cdc067cd4ee7ad01f08951fe6e15.json"}}, {"family": "Cao", "given": "Yihai", "initials": "Y", "orcid": "0000-0003-1308-0065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e94efe139da46f3888539ccf8c6d6cf.json"}}], "type": "clinical trial", "published": "2021-02-05", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "814"}, "abstract": "On the basis of Covid-19-induced pulmonary pathological and vascular changes, we hypothesize that the anti-vascular endothelial growth factor (VEGF) drug bevacizumab might be beneficial for treating Covid-19 patients. From Feb 15 to April 5, 2020, we conducted a single-arm trial (NCT04275414) and recruited 26 patients from 2-centers (China and Italy) with severe Covid-19, with respiratory rate \u226530 times/min, oxygen saturation \u226493% with ambient air, or partial arterial oxygen pressure to fraction of inspiration O2 ratio (PaO2/FiO2) >100 mmHg and \u2264300 mmHg, and diffuse pneumonia confirmed by chest imaging. Followed up for 28 days. Among these, bevacizumab plus standard care markedly improves the PaO2/FiO2 ratios at days 1 and 7. By day 28, 24 (92%) patients show improvement in oxygen-support status, 17 (65%) patients are discharged, and none show worsen oxygen-support status nor die. Significant reduction of lesion areas/ratios are shown in chest computed tomography (CT) or X-ray within 7 days. Of 14 patients with fever, body temperature normalizes within 72 h in 13 (93%) patients. Relative to comparable controls, bevacizumab shows clinical efficacy by improving oxygenation and shortening oxygen-support duration. Our findings suggest bevacizumab plus standard care is highly beneficial for patients with severe Covid-19. Randomized controlled trial is warranted.", "doi": "10.1038/s41467-021-21085-8", "pmid": "33547300", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC7864918"}, {"db": "pii", "key": "10.1038/s41467-021-21085-8"}, {"db": "ClinicalTrials.gov", "key": "NCT04275414"}, {"db": "figshare", "key": "10.6084/m9.figshare.13482810"}, {"db": "figshare", "key": "10.6084/m9.figshare.13482834"}], "notes": [], "created": "2021-02-05T11:00:55.502Z", "modified": "2023-06-19T14:36:24.662Z"}, {"entity": "publication", "iuid": "95af2e1173584d369a02dd581c426f45", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95af2e1173584d369a02dd581c426f45.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95af2e1173584d369a02dd581c426f45"}}, "title": "The impact of COVID-19 on oncology professionals: results of the ESMO Resilience Task Force survey collaboration.", "authors": [{"family": "Banerjee", "given": "S", "initials": "S"}, {"family": "Lim", "given": "K H J", "initials": "KHJ"}, {"family": "Murali", "given": "K", "initials": "K"}, {"family": "Kamposioras", "given": "K", "initials": "K"}, {"family": "Punie", "given": "K", "initials": "K"}, {"family": "Oing", "given": "C", "initials": "C"}, {"family": "O'Connor", "given": "M", "initials": "M"}, {"family": "Thorne", "given": "E", "initials": "E"}, {"family": "Devnani", "given": "B", "initials": "B"}, {"family": "Lambertini", "given": "M", "initials": "M"}, {"family": "Westphalen", "given": "C B", "initials": "CB"}, {"family": "Garrido", "given": "P", "initials": "P"}, {"family": "Amaral", "given": "T", "initials": "T"}, {"family": "Morgan", "given": "G", "initials": "G"}, {"family": "Haanen", "given": "J B A G", "initials": "JBAG"}, {"family": "Hardy", "given": "C", "initials": "C"}], "type": "journal article", "published": "2021-02-04", "journal": {"title": "ESMO Open", "issn": "2059-7029", "issn-l": null, "volume": "6", "issue": "2", "pages": "100058"}, "abstract": "The impact of the coronavirus disease 2019 (COVID-19) pandemic on well-being has the potential for serious negative consequences on work, home life, and patient care. The European Society for Medical Oncology (ESMO) Resilience Task Force collaboration set out to investigate well-being in oncology over time since COVID-19.\r\n\r\nTwo online anonymous surveys were conducted (survey I: April/May 2020; survey II: July/August 2020). Statistical analyses were performed to examine group differences, associations, and predictors of key outcomes: (i) well-being/distress [expanded Well-being Index (eWBI; 9 items)]; (ii) burnout (1 item from eWBI); (iii) job performance since COVID-19 (JP-CV; 2 items).\r\n\r\nResponses from survey I (1520 participants from 101 countries) indicate that COVID-19 is impacting oncology professionals; in particular, 25% of participants indicated being at risk of distress (poor well-being, eWBI \u2265 4), 38% reported feeling burnout, and 66% reported not being able to perform their job compared with the pre-COVID-19 period. Higher JP-CV was associated with better well-being and not feeling burnout (P < 0.01). Differences were seen in well-being and JP-CV between countries (P < 0.001) and were related to country COVID-19 crude mortality rate (P < 0.05). Consistent predictors of well-being, burnout, and JP-CV were psychological resilience and changes to work hours. In survey II, among 272 participants who completed both surveys, while JP-CV improved (38% versus 54%, P < 0.001), eWBI scores \u22654 and burnout rates were significantly higher compared with survey I (22% versus 31%, P = 0.01; and 35% versus 49%, P = 0.001, respectively), suggesting well-being and burnout have worsened over a 3-month period during the COVID-19 pandemic.\r\n\r\nIn the first and largest global survey series, COVID-19 is impacting well-being and job performance of oncology professionals. JP-CV has improved but risk of distress and burnout has increased over time. Urgent measures to address well-being and improve resilience are essential.", "doi": "10.1016/j.esmoop.2021.100058", "pmid": "33601295", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2059-7029(21)00013-2"}], "notes": [], "created": "2021-02-19T14:07:28.255Z", "modified": "2021-06-18T11:32:37.310Z"}, {"entity": "publication", "iuid": "9289ed9c644f4e02942703bee07dda08", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9289ed9c644f4e02942703bee07dda08.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9289ed9c644f4e02942703bee07dda08"}}, "title": "DNA-launched RNA replicon vaccines induce potent anti-SARS-CoV-2 immune responses in mice", "authors": [{"family": "Szurgot", "given": "Inga", "initials": "I"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Vidakovics", "given": "Laura Perez", "initials": "LP"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}, {"family": "Liljestr\u00f6m", "given": "Peter", "initials": "P"}], "type": "journal-article", "published": "2021-02-04", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "3125"}, "abstract": "The outbreak of the SARS-CoV-2 virus and its rapid spread into a global pandemic made the urgent development of scalable vaccines to prevent coronavirus disease (COVID-19) a global health and economic imperative. Here, we characterized and compared the immunogenicity of two alphavirus-based DNA-launched self-replicating (DREP) vaccine candidates encoding either SARS-CoV-2 spike glycoprotein (DREP-S) or a spike ectodomain trimer stabilized in prefusion conformation (DREP-S ecto). We observed that the two DREP constructs were immunogenic in mice inducing both binding and neutralizing antibodies as well as T cell responses. Interestingly, the DREP coding for the unmodified spike turned out to be more potent vaccine candidate, eliciting high titers of SARS-CoV-2 specific IgG antibodies that were able to efficiently neutralize pseudotyped virus after a single immunization. In addition, both DREP constructs were able to efficiently prime responses that could be boosted with a heterologous spike protein immunization. These data provide important novel insights into SARS-CoV-2 vaccine design using a rapid response DNA vaccine platform. Moreover, they encourage the use of mixed vaccine modalities as a strategy to combat SARS-CoV-2.", "doi": "10.1038/s41598-021-82498-5", "pmid": "33542325", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Drug Discovery": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-02-04T20:58:59.276Z", "modified": "2021-12-07T15:32:28.810Z"}, {"entity": "publication", "iuid": "c14184ccb8cd435ca5b458a45a37aa30", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c14184ccb8cd435ca5b458a45a37aa30.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c14184ccb8cd435ca5b458a45a37aa30"}}, "title": "The male disadvantage in life expectancy: can we close the gender gap?", "authors": [{"family": "Hossin", "given": "Muhammad Zakir", "initials": "MZ"}], "type": "journal-article", "published": "2021-02-03", "journal": {"title": "Int Health", "issn": "1876-3405", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Men are usually considered to be the stronger sex. However, when it comes to health, they are evidently weaker than their female counterparts. In almost all countries around the world, men consistently live shorter lives than women. The gender gap in longevity has once again been evident during the ongoing coronavirus disease 2019 (COVID-19) pandemic, which kills men disproportionately. Drawing on the relevant scientific literature and updated information, this article aimed to provide useful insights into the biological and social mechanisms that potentially underlie the gender gap in life expectancy.", "doi": "10.1093/inthealth/ihaa106", "pmid": "33533409", "labels": {"Type: Other": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6127106"}], "notes": [], "created": "2021-02-04T18:12:38.304Z", "modified": "2021-06-18T11:21:35.267Z"}, {"entity": "publication", "iuid": "f9a0683bd2434fbdafbc5b3ab6408805", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f9a0683bd2434fbdafbc5b3ab6408805.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f9a0683bd2434fbdafbc5b3ab6408805"}}, "title": "Differential expression of Angiotensin-Converting Enzyme 2 in Nasal Tissue of Patients with Chronic Rhinosinusitis with Nasal Polyps", "authors": [{"family": "Fowler", "given": "Philippa C", "initials": "PC"}, {"family": "Naluai", "given": "\u00c5sa Torinsson", "initials": "\u00c5T"}, {"family": "Oscarsson", "given": "Martin", "initials": "M"}, {"family": "Torkzadeh", "given": "Sara", "initials": "S"}, {"family": "Bohman", "given": "Anton", "initials": "A"}, {"family": "Bende", "given": "Mats", "initials": "M"}, {"family": "Harandi", "given": "Ali M", "initials": "AM"}], "type": "posted-content", "published": "2021-02-03", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.01.21250623", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-02-11T15:43:20.813Z", "modified": "2021-06-17T08:02:05.809Z"}, {"entity": "publication", "iuid": "673c6de5246548888c52474ae57417cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/673c6de5246548888c52474ae57417cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/673c6de5246548888c52474ae57417cc"}}, "title": "COVID-19 Herd Immunity in the Absence of a Vaccine: An Irresponsible Approach.", "authors": [{"family": "Khalife", "given": "Jade", "initials": "J"}, {"family": "VanGennep", "given": "Derrick", "initials": "D"}], "type": "journal article", "published": "2021-02-03", "journal": {"title": "Epidemiol Health", "issn": "2092-7193", "volume": null, "issue": null, "pages": "e2021012", "issn-l": null}, "abstract": "With SARS-CoV-2 continuing to spread rapidly throughout the human population, the concept of 'herd immunity' has been attracting the attention of both decision makers and the general public. In the absence of a vaccine, this entails that a large proportion of the population be infected to develop immunity that would limit the severity and/or extent of subsequent outbreaks. We argue that adopting such an approach should be avoided for several reasons: There are significant uncertainties about whether achieving herd immunity is possible. If possible, achieving herd immunity would impose a large burden on society. There are gaps in protection, making it difficult to shield the vulnerable. It would defeat the purpose of avoiding harm caused by the virus. Lastly, dozens of countries are showing that containment is possible.", "doi": "10.4178/epih.e2021012", "pmid": "33541010", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "epih.e2021012"}], "notes": [], "created": "2021-02-05T11:29:57.851Z", "modified": "2021-02-05T11:29:57.876Z"}, {"entity": "publication", "iuid": "82ee9b48aa8b42e2a02f0d191c2674af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82ee9b48aa8b42e2a02f0d191c2674af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82ee9b48aa8b42e2a02f0d191c2674af"}}, "title": "The international Perinatal Outcomes in the Pandemic (iPOP) study: protocol.", "authors": [{"family": "Stock", "given": "Sarah J", "initials": "SJ", "orcid": "0000-0003-4308-856X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c04f8cfa9161491eb157b1bea4cc8a6a.json"}}, {"family": "Zoega", "given": "Helga", "initials": "H", "orcid": "0000-0003-0761-9028", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52887f3b5931453494a3416c0b97ce9b.json"}}, {"family": "Brockway", "given": "Meredith", "initials": "M"}, {"family": "Mulholland", "given": "Rachel H", "initials": "RH"}, {"family": "Miller", "given": "Jessica E", "initials": "JE", "orcid": "0000-0002-1806-1894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d973c66d5b5c4f779651915daa7b305c.json"}}, {"family": "Been", "given": "Jasper V", "initials": "JV", "orcid": "0000-0002-4907-6466", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27a8e734cc6a49f6ba5f9f25dc6f4235.json"}}, {"family": "Wood", "given": "Rachael", "initials": "R", "orcid": "0000-0003-4453-623X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cffadf504ae4f9eac53cdc2a00ffb8a.json"}}, {"family": "Abok", "given": "Ishaya I", "initials": "II"}, {"family": "Alshaikh", "given": "Belal", "initials": "B", "orcid": "0000-0002-6080-6888", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4fd691f58969420c9695cfc7645f8d31.json"}}, {"family": "Ayede", "given": "Adejumoke I", "initials": "AI"}, {"family": "Bacchini", "given": "Fabiana", "initials": "F", "orcid": "0000-0003-4343-774X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3722ddcfd11442d68ba7c8fb79abd694.json"}}, {"family": "Bhutta", "given": "Zulfiqar A", "initials": "ZA"}, {"family": "Brew", "given": "Bronwyn K", "initials": "BK"}, {"family": "Brook", "given": "Jeffrey", "initials": "J"}, {"family": "Calvert", "given": "Clara", "initials": "C"}, {"family": "Campbell-Yeo", "given": "Marsha", "initials": "M", "orcid": "0000-0001-6645-2809", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3004a18f0ace4dbb8d828698c2123337.json"}}, {"family": "Chan", "given": "Deborah", "initials": "D"}, {"family": "Chirombo", "given": "James", "initials": "J", "orcid": "0000-0003-3132-3710", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebca6beba4e44841be3edf1f15431ca6.json"}}, {"family": "Connor", "given": "Kristin L", "initials": "KL"}, {"family": "Daly", "given": "Mandy", "initials": "M", "orcid": "0000-0001-7539-4874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10829e2a02064b19a2472c5c82c2bf0e.json"}}, {"family": "Einarsd\u00f3ttir", "given": "Kristjana", "initials": "K", "orcid": "0000-0003-4931-7650", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b9f81f471fa43c2a372d34651f0c64e.json"}}, {"family": "Fantasia", "given": "Ilaria", "initials": "I"}, {"family": "Franklin", "given": "Meredith", "initials": "M"}, {"family": "Fraser", "given": "Abigail", "initials": "A", "orcid": "0000-0002-7741-9470", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f1caaab396a4cf1a2b2e6f9f4442684.json"}}, {"family": "H\u00e5berg", "given": "Siri Eldevik", "initials": "SE"}, {"family": "Hui", "given": "Lisa", "initials": "L"}, {"family": "Huicho", "given": "Luis", "initials": "L"}, {"family": "Magnus", "given": "Maria C", "initials": "MC", "orcid": "0000-0002-0568-3774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3530918cfd534021a45a80628c89c580.json"}}, {"family": "Morris", "given": "Andrew D", "initials": "AD"}, {"family": "Nagy-Bonnard", "given": "Livia", "initials": "L"}, {"family": "Nassar", "given": "Natasha", "initials": "N"}, {"family": "Nyadanu", "given": "Sylvester Dodzi", "initials": "SD"}, {"family": "Iyabode Olabisi", "given": "Dedeke", "initials": "D"}, {"family": "Palmer", "given": "Kirsten R", "initials": "KR"}, {"family": "Pedersen", "given": "Lars Henning", "initials": "LH", "orcid": "0000-0001-6726-1991", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1ad7974d474490db8e59e0211b560d7.json"}}, {"family": "Pereira", "given": "Gavin", "initials": "G"}, {"family": "Racine-Poon", "given": "Amy", "initials": "A"}, {"family": "Ranger", "given": "Manon", "initials": "M", "orcid": "0000-0001-8253-0686", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73deca7ec726431085d33dc7edcf8435.json"}}, {"family": "Rihs", "given": "Tonia", "initials": "T"}, {"family": "Saner", "given": "Christoph", "initials": "C", "orcid": "0000-0003-1380-0341", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e95e43b46b343fab9da330d1ab34bed.json"}}, {"family": "Sheikh", "given": "Aziz", "initials": "A", "orcid": "0000-0001-7022-3056", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82e1b46e1bd74c51a84294d5fe0326da.json"}}, {"family": "Swift", "given": "Emma M", "initials": "EM", "orcid": "0000-0001-9476-130X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b583b9bece114d069a239a41813e68f1.json"}}, {"family": "Tooke", "given": "Lloyd", "initials": "L"}, {"family": "Urquia", "given": "Marcelo L", "initials": "ML"}, {"family": "Whitehead", "given": "Clare", "initials": "C", "orcid": "0000-0001-8267-1630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2aaf1b678b3e44f2bc9224e29198ee05.json"}}, {"family": "Yilgwan", "given": "Christopher", "initials": "C", "orcid": "0000-0003-4741-7009", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2610d1daa034c88818778cf507e7dfe.json"}}, {"family": "Rodriguez", "given": "Natalie", "initials": "N"}, {"family": "Burgner", "given": "David", "initials": "D", "orcid": "0000-0002-8304-4302", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/300873d0d8e6457487f9d120f43ecd75.json"}}, {"family": "Azad", "given": "Meghan B", "initials": "MB", "orcid": "0000-0002-5942-4444", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/283604a1391c483f931b22e45f7a7edb.json"}}, {"family": "iPOP Study Team", "given": "", "initials": ""}], "type": "journal article", "published": "2021-02-02", "journal": {"title": "Wellcome Open Res", "issn": "2398-502X", "volume": "6", "pages": "21", "issn-l": null}, "abstract": "Preterm birth is the leading cause of infant death worldwide, but the causes of preterm birth are largely unknown. During the early COVID-19 lockdowns, dramatic reductions in preterm birth were reported; however, these trends may be offset by increases in stillbirth rates. It is important to study these trends globally as the pandemic continues, and to understand the underlying cause(s). Lockdowns have dramatically impacted maternal workload, access to healthcare, hygiene practices, and air pollution - all of which could impact perinatal outcomes and might affect pregnant women differently in different regions of the world. In the international Perinatal Outcomes in the Pandemic (iPOP) Study, we will seize the unique opportunity offered by the COVID-19 pandemic to answer urgent questions about perinatal health. In the first two study phases, we will use population-based aggregate data and standardized outcome definitions to: 1) Determine rates of preterm birth, low birth weight, and stillbirth and describe changes during lockdowns; and assess if these changes are consistent globally, or differ by region and income setting, 2) Determine if the magnitude of changes in adverse perinatal outcomes during lockdown are modified by regional differences in COVID-19 infection rates, lockdown stringency, adherence to lockdown measures, air quality, or other social and economic markers, obtained from publicly available datasets. We will undertake an interrupted time series analysis covering births from January 2015 through July 2020. The iPOP Study will involve at least 121 researchers in 37 countries, including obstetricians, neonatologists, epidemiologists, public health researchers, environmental scientists, and policymakers. We will leverage the most disruptive and widespread \"natural experiment\" of our lifetime to make rapid discoveries about preterm birth. Whether the COVID-19 pandemic is worsening or unexpectedly improving perinatal outcomes, our research will provide critical new information to shape prenatal care strategies throughout (and well beyond) the pandemic.", "doi": "10.12688/wellcomeopenres.16507.1", "pmid": "34722933", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8524299"}], "notes": [], "created": "2021-11-02T15:31:32.649Z", "modified": "2021-11-02T15:31:33.258Z"}, {"entity": "publication", "iuid": "98576a905b2949ec84bfa0e9efb649c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/98576a905b2949ec84bfa0e9efb649c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/98576a905b2949ec84bfa0e9efb649c0"}}, "title": "Give more data, awareness and control to individual citizens, and they will help COVID-19 containment.", "authors": [{"family": "Nanni", "given": "Mirco", "initials": "M"}, {"family": "Andrienko", "given": "Gennady", "initials": "G"}, {"family": "Barab\u00e1si", "given": "Albert-L\u00e1szl\u00f3", "initials": "AL"}, {"family": "Boldrini", "given": "Chiara", "initials": "C"}, {"family": "Bonchi", "given": "Francesco", "initials": "F"}, {"family": "Cattuto", "given": "Ciro", "initials": "C"}, {"family": "Chiaromonte", "given": "Francesca", "initials": "F"}, {"family": "Comand\u00e9", "given": "Giovanni", "initials": "G"}, {"family": "Conti", "given": "Marco", "initials": "M"}, {"family": "Cot\u00e9", "given": "Mark", "initials": "M"}, {"family": "Dignum", "given": "Frank", "initials": "F"}, {"family": "Dignum", "given": "Virginia", "initials": "V"}, {"family": "Domingo-Ferrer", "given": "Josep", "initials": "J"}, {"family": "Ferragina", "given": "Paolo", "initials": "P"}, {"family": "Giannotti", "given": "Fosca", "initials": "F"}, {"family": "Guidotti", "given": "Riccardo", "initials": "R"}, {"family": "Helbing", "given": "Dirk", "initials": "D"}, {"family": "Kaski", "given": "Kimmo", "initials": "K"}, {"family": "Kertesz", "given": "Janos", "initials": "J"}, {"family": "Lehmann", "given": "Sune", "initials": "S"}, {"family": "Lepri", "given": "Bruno", "initials": "B"}, {"family": "Lukowicz", "given": "Paul", "initials": "P"}, {"family": "Matwin", "given": "Stan", "initials": "S"}, {"family": "Jim\u00e9nez", "given": "David Meg\u00edas", "initials": "DM"}, {"family": "Monreale", "given": "Anna", "initials": "A"}, {"family": "Morik", "given": "Katharina", "initials": "K"}, {"family": "Oliver", "given": "Nuria", "initials": "N"}, {"family": "Passarella", "given": "Andrea", "initials": "A"}, {"family": "Passerini", "given": "Andrea", "initials": "A"}, {"family": "Pedreschi", "given": "Dino", "initials": "D"}, {"family": "Pentland", "given": "Alex", "initials": "A"}, {"family": "Pianesi", "given": "Fabio", "initials": "F"}, {"family": "Pratesi", "given": "Francesca", "initials": "F"}, {"family": "Rinzivillo", "given": "Salvatore", "initials": "S"}, {"family": "Ruggieri", "given": "Salvatore", "initials": "S"}, {"family": "Siebes", "given": "Arno", "initials": "A"}, {"family": "Torra", "given": "Vicenc", "initials": "V"}, {"family": "Trasarti", "given": "Roberto", "initials": "R"}, {"family": "Hoven", "given": "Jeroen van den", "initials": "JVD"}, {"family": "Vespignani", "given": "Alessandro", "initials": "A"}], "type": "journal article", "published": "2021-02-02", "journal": {"title": "Ethics Inf Technol", "issn": "1388-1957", "volume": null, "issue": null, "pages": "1-6", "issn-l": null}, "abstract": "The rapid dynamics of COVID-19 calls for quick and effective tracking of virus transmission chains and early detection of outbreaks, especially in the \"phase 2\" of the pandemic, when lockdown and other restriction measures are progressively withdrawn, in order to avoid or minimize contagion resurgence. For this purpose, contact-tracing apps are being proposed for large scale adoption by many countries. A centralized approach, where data sensed by the app are all sent to a nation-wide server, raises concerns about citizens' privacy and needlessly strong digital surveillance, thus alerting us to the need to minimize personal data collection and avoiding location tracking. We advocate the conceptual advantage of a decentralized approach, where both contact and location data are collected exclusively in individual citizens' \"personal data stores\", to be shared separately and selectively (e.g., with a backend system, but possibly also with other citizens), voluntarily, only when the citizen has tested positive for COVID-19, and with a privacy preserving level of granularity. This approach better protects the personal sphere of citizens and affords multiple benefits: it allows for detailed information gathering for infected people in a privacy-preserving fashion; and, in turn this enables both contact tracing, and, the early detection of outbreak hotspots on more finely-granulated geographic scale. The decentralized approach is also scalable to large populations, in that only the data of positive patients need be handled at a central level. Our recommendation is two-fold. First to extend existing decentralized architectures with a light touch, in order to manage the collection of location data locally on the device, and allow the user to share spatio-temporal aggregates-if and when they want and for specific aims-with health authorities, for instance. Second, we favour a longer-term pursuit of realizing a Personal Data Store vision, giving users the opportunity to contribute to collective good in the measure they want, enhancing self-awareness, and cultivating collective efforts for rebuilding society.", "doi": "10.1007/s10676-020-09572-w", "pmid": "33551673", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "9572"}, {"db": "pmc", "key": "PMC7851322"}], "notes": [], "created": "2021-02-10T18:48:38.200Z", "modified": "2021-02-10T18:48:38.209Z"}, {"entity": "publication", "iuid": "d1867d7cef094b43aa4ba9d4261915fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1867d7cef094b43aa4ba9d4261915fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1867d7cef094b43aa4ba9d4261915fd"}}, "title": "The local governance of COVID-19: Disease prevention and social security in rural India.", "authors": [{"family": "Dutta", "given": "Anwesha", "initials": "A"}, {"family": "Fischer", "given": "Harry W", "initials": "HW"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "World Dev", "issn": "0305-750X", "issn-l": null, "volume": "138", "issue": null, "pages": "105234"}, "abstract": "Countries around the world have undertaken a wide range of strategies to halt the spread of COVID-19 and control the economic fallout left in its wake. Rural areas of developing countries pose particular difficulties for developing and implementing effective responses owing to underdeveloped health infrastructure, uneven state capacity for infection control, and endemic poverty. This paper makes the case for the critical role of local governance in coordinating pandemic response by examining how state authorities are attempting to bridge the gap between the need for rapid, vigorous response to the pandemic and local realities in three Indian states - Rajasthan, Odisha, and Kerala. Through a combination of interviews with mid and low-level bureaucrats and a review of policy documents, we show how the urgency of COVID-19 response has galvanized new kinds of cross-sectoral and multi-scalar interaction between administrative units involved in coordinating responses, as local governments have assumed central responsibility in the implementation of disease control and social security mechanisms. Evidence from Kerala in particular suggests that the state's long term investment in democratic local government and arrangements for incorporating women within grassroots state functions (through its Kudumbashree program) has built a high degree of public trust and cooperation with state actors, while local authorities embrace an ethic of care in the implementation of state responses. These observations, from the early months of the pandemic in South Asia, can serve as a foundation for future studies of how existing institutional arrangements and their histories pattern the long-term success of disease control and livelihood support as the pandemic proceeds. Governance, we argue, will be as important to understanding the trajectory of COVID-19 impacts and recovery as biology, demography, and economy.", "doi": "10.1016/j.worlddev.2020.105234", "pmid": "33106724", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0305-750X(20)30361-2"}, {"db": "pmc", "key": "PMC7578699"}], "notes": [], "created": "2020-11-27T11:47:52.870Z", "modified": "2021-01-22T16:08:54.437Z"}, {"entity": "publication", "iuid": "2f879921db144584abafdc455753d1da", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2f879921db144584abafdc455753d1da.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2f879921db144584abafdc455753d1da"}}, "title": "Richard Horton. The COVID-19 Catastrophe. What\u2019s Gone Wrong and How to Stop it Happening Again?", "authors": [{"family": "Allebeck", "given": "Peter", "initials": "P", "orcid": "0000-0002-2778-6467", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de9f0e1c3e4d402b93e61ad1c5a771fb.json"}}], "type": "journal-article", "published": "2021-02-01", "journal": {"title": "Eur J Public Health", "issn": "1101-1262", "volume": "31", "issue": "1", "pages": "234-234", "issn-l": null}, "abstract": null, "doi": "10.1093/eurpub/ckaa216", "pmid": "33231611", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "5998562"}], "notes": [], "created": "2020-11-26T12:36:05.407Z", "modified": "2023-06-19T07:33:25.394Z"}, {"entity": "publication", "iuid": "f01c7f0716244665a5ce072be3c80321", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f01c7f0716244665a5ce072be3c80321.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f01c7f0716244665a5ce072be3c80321"}}, "title": "Pregnant under the pressure of a pandemic: a large-scale longitudinal survey before and during the COVID-19 outbreak.", "authors": [{"family": "Naurin", "given": "Elin", "initials": "E"}, {"family": "Markstedt", "given": "Elias", "initials": "E"}, {"family": "Stolle", "given": "Dietlind", "initials": "D"}, {"family": "Enstr\u00f6m", "given": "Daniel", "initials": "D"}, {"family": "Wallin", "given": "Anton", "initials": "A"}, {"family": "Andreasson", "given": "Ingrid", "initials": "I"}, {"family": "Attebo", "given": "Birgitta", "initials": "B"}, {"family": "Eriksson", "given": "Ottilia", "initials": "O"}, {"family": "Martinsson", "given": "Klara", "initials": "K"}, {"family": "Elden", "given": "Helen", "initials": "H"}, {"family": "Linden", "given": "Karolina", "initials": "K"}, {"family": "Sengpiel", "given": "Verena", "initials": "V"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": "31", "issue": "1", "pages": "7-13"}, "abstract": "One of the groups that is most vulnerable to the COVID-19 pandemic is pregnant women. They cannot choose to refrain from care; they and their children are at risk of severe complications related to the virus; and they lose comfort and support as clinics prohibit their partners and as societal restrictions demand isolation from friends and relatives. It is urgent to study how this group is faring during the pandemic and we focus here on their health-related worries.\r\n\r\nA longitudinal survey at a Swedish hospital starting 6 months before (16 September 2019) and continuing during the COVID-19 outbreak (until 25 August 2020). A total of 6941 pregnant women and partners of diverse social backgrounds were recruited. Ninety-six percent of birth-giving women in the city take early ultrasounds where recruitment took place. Sixty-two percent of the women with an appointment and fifty-one percent of all partners gave consent to participate.\r\n\r\nPregnant women experienced dramatically increased worries for their own health, as well as for their partner's and their child's health in the beginning of the pandemic. The worries remained at higher than usual levels throughout the pandemic. Similar, but less dramatic changes were seen among partners.\r\n\r\nThere is a need for heightened awareness of pregnant women's and partners' health-related worries as a consequence of the COVID-19 pandemic. Related feelings, such as anxiety, have been linked to adverse pregnancy outcome and might have long-term effects. The healthcare system needs to prepare for follow-up visits with these families.", "doi": "10.1093/eurpub/ckaa223", "pmid": "33231625", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "5999799"}, {"db": "pmc", "key": "PMC7717243"}], "notes": [], "created": "2021-02-10T18:53:52.023Z", "modified": "2021-06-18T11:48:16.756Z"}, {"entity": "publication", "iuid": "d3af55f4e3e041e991b21009616ebc1b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3af55f4e3e041e991b21009616ebc1b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3af55f4e3e041e991b21009616ebc1b"}}, "title": "Inflammatory bowel disease and risk of severe COVID-19: A nationwide population-based cohort study in Sweden.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}, {"family": "Axelrad", "given": "Jordan", "initials": "J"}, {"family": "Halfvarson", "given": "Jonas", "initials": "J"}, {"family": "Khalili", "given": "Hamed", "initials": "H"}, {"family": "Larsson", "given": "Emma", "initials": "E"}, {"family": "Lochhead", "given": "Paul", "initials": "P"}, {"family": "Roelstraete", "given": "Bjorn", "initials": "B"}, {"family": "Simon", "given": "Tracey G", "initials": "TG"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Ol\u00e9n", "given": "Ola", "initials": "O"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "United European Gastroenterol J", "issn": "2050-6414", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "There are concerns that individuals with chronic immune-mediated diseases are at increased risk of COVID-19 and related severe adverse outcome, including intensive care admission or death. We aimed to explore the absolute and relative risk of severe COVID-19 in inflammatory bowel disease (IBD).\r\n\r\nThis population-based cohort study used nationwide registers in Sweden, with 67,292 individuals with a diagnosis of IBD 1969-2017 (Crohn's disease, n = 21,599; ulcerative colitis: n = 43,622; IBD-unclassified: n = 2071) and alive on 1 February 2020. Patients with IBD were matched to up to five controls from the general population (n = 297,910). Cox regression estimated hazard ratios (HRs) for (i) hospital admission with laboratory-confirmed COVID-19 as the primary diagnosis, and (ii) severe COVID-19 (composite outcome consisting of (a) COVID-19 intensive care admission, or (b) death from COVID-19 or (c) death within 30 days of COVID-19 hospital admission), were calculated. Analyses were conditioned on age, sex, calendar period, and county and adjusted for other comorbidities.\r\n\r\nBetween 1 February and 31 July 2020, 179 (0.27%) IBD patients and 500 (0.17%) general population controls were admitted to hospital with COVID-19 (adjusted HR [aHR] = 1.43; 95% CI = 1.19-1.72). The corresponding numbers for severe COVID-19 was 65 (0.10%) and 183 (0.06%; aHR = 1.11; 95% CI = 0.81-1.52). Adjusted HRs were similar in Crohn's disease and ulcerative colitis. In a propensity score-matched model taking comorbidity into account until 2016, the increased risk for COVID-19 hospital admission remained (aHR = 1.32; 1.12-1.56), but there was no increased risk of severe COVID-19 (aHR = 1.12; 0.85-1.47).\r\n\r\nWhile individuals with IBD were more likely to be admitted to hospital for COVID-19 than the general population, the risk of severe COVID-19 was not higher.", "doi": "10.1002/ueg2.12049", "pmid": "33704918", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-12T07:00:21.836Z", "modified": "2021-06-18T11:48:54.131Z"}, {"entity": "publication", "iuid": "87a74bf619444236aae8b3fba8ddf289", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87a74bf619444236aae8b3fba8ddf289.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87a74bf619444236aae8b3fba8ddf289"}}, "title": "Impact of COVID-19 lockdown on NO 2, O3, PM2.5 and PM10 concentrations and assessing air quality changes in Baghdad, Iraq.", "authors": [{"family": "Hashim", "given": "Bassim Mohammed", "initials": "BM"}, {"family": "Al-Naseri", "given": "Saadi K", "initials": "SK"}, {"family": "Al-Maliki", "given": "Ali", "initials": "A"}, {"family": "Al-Ansari", "given": "Nadhir", "initials": "N"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "volume": "754", "issue": null, "pages": "141978", "issn-l": "0048-9697"}, "abstract": "Covid-19 was first reported in Iraq on February 24, 2020. Since then, to prevent its propagation, the Iraqi government declared a state of health emergency. A set of rapid and strict countermeasures have taken, including locking down cities and limiting population's mobility. In this study, concentrations of four criteria pollutants, NO 2, O3, PM2.5 and PM10 before the lockdown from January 16 to February 29, 2020, and during four periods of partial and total lockdown from March 1 to July 24, 2020, in Baghdad were analysed. Overall, 6, 8 and 15% decreases in NO2, PM2.5, and PM10 concentrations, respectively in Baghdad during the 1st partial and total lockdown from March 1 to April 21, compared to the period before the lockdown. While, there were 13% increase in O3 for same period. During the 2nd partial lockdown from June 14 to July 24, NO2 and PM2.5 decreases 20 and 2.5%, respectively. While, there were 525 and 56% increase in O3 and PM10, respectively for same period. The air quality index (AQI) improved by 13% in Baghdad during the 1st partial lockdown from March 1 to April 21, compared to its pre-lockdown. The results of NO2 tropospheric column extracted from the Sentinel-5P satellite shown the NO2 emissions reduced up to 35 to 40% across Iraq, due to lockdown measures, between January and July, 2020, especially across the major cities such as Baghdad, Basra and Erbil. The lockdown due to COVID-19 has drastic effects on social and economic aspects. However, the lockdown also has some positive effect on natural environment and air quality improvement.", "doi": "10.1016/j.scitotenv.2020.141978", "pmid": "32919315", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(20)35507-8"}, {"db": "pmc", "key": "PMC7462443"}], "notes": [], "created": "2020-12-03T15:39:23.953Z", "modified": "2021-02-26T08:46:13.355Z"}, {"entity": "publication", "iuid": "636180d45c4142939f2ff87323885946", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/636180d45c4142939f2ff87323885946.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/636180d45c4142939f2ff87323885946"}}, "title": "Funcoup 5: Functional association networks in all domains of life, supporting directed links and tissue-specificity.", "authors": [{"family": "Persson", "given": "Emma", "initials": "E"}, {"family": "Castresana-Aguirre", "given": "Miguel", "initials": "M"}, {"family": "Buzzao", "given": "Davide", "initials": "D"}, {"family": "Guala", "given": "Dimitri", "initials": "D"}, {"family": "Sonnhammer", "given": "Erik L L", "initials": "ELL"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "J Mol Biol", "issn": "1089-8638", "issn-l": null, "volume": null, "issue": null, "pages": "166835"}, "abstract": "FunCoup (https://funcoup.sbc.su.se) is one of the most comprehensive functional association networks of genes/proteins available. Functional associations are inferred by integrating different types of evidence using a redundancy-weighted na\u00efve Bayesian approach, combined with orthology transfer. FunCoup's high coverage comes from using eleven different types of evidence, and extensive transfer of information between species. Since the latest update of the database, the availability of source data has improved drastically, and user expectations on a tool for functional associations have grown. To meet these requirements, we have made a new release of FunCoup with updated source data and improved functionality. FunCoup 5 now includes 22 species from all domains of life, and the source data for evidences, gold standards, and genomes have been updated to the latest available versions. In this new release, directed regulatory links inferred from transcription factor binding can be visualized in the network viewer for the human interactome. Another new feature is the possibility to filter by genes expressed in a certain tissue in the network viewer. FunCoup 5 further includes the SARS-CoV-2 proteome, allowing users to visualize and analyze interactions between SARS-CoV-2 and human proteins in order to better understand COVID-19. This new release of FunCoup constitutes a major advance for the users, with updated sources, new species and improved functionality for analysis of the networks.", "doi": "10.1016/j.jmb.2021.166835", "pmid": "33539890", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0022-2836(21)00029-2"}], "notes": [], "created": "2021-02-05T11:28:55.073Z", "modified": "2021-08-25T14:25:20.925Z"}, {"entity": "publication", "iuid": "9b6e4f24074b4cdb818625428a92e182", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b6e4f24074b4cdb818625428a92e182.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b6e4f24074b4cdb818625428a92e182"}}, "title": "Excess mortality from COVID-19: weekly excess death rates by age and sex for Sweden and its most affected region.", "authors": [{"family": "Modig", "given": "Karin", "initials": "K"}, {"family": "Ahlbom", "given": "Anders", "initials": "A"}, {"family": "Ebeling", "given": "Marcus", "initials": "M"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": "31", "issue": "1", "pages": "17-22"}, "abstract": "Sweden has one of the highest numbers of COVID-19 deaths per inhabitant globally. However, absolute death counts can be misleading. Estimating age- and sex-specific mortality rates is necessary in order to account for the underlying population structure. Furthermore, given the difficulty of assigning causes of death, excess all-cause mortality should be estimated to assess the overall burden of the pandemic.\n\nBy estimating weekly age- and sex-specific death rates during 2020 and during the preceding 5 years, our aim is to get more accurate estimates of the excess mortality attributed to COVID-19 in Sweden, and in the most affected region Stockholm.\n\nEight weeks after Sweden's first confirmed case, the death rates at all ages above 60 were higher than for previous years. Persons above age 80 were disproportionally more affected, and men suffered greater excess mortality than women in ages up to 75 years. At older ages, the excess mortality was similar for men and women, with up to 1.5 times higher death rates for Sweden and up to 3 times higher for Stockholm. Life expectancy at age 50 declined by <1 year for Sweden and 1.5 years for Stockholm compared to 2019.\n\nThe excess mortality has been high in older ages during the pandemic, but it remains to be answered if this is because of age itself being a prognostic factor or a proxy for comorbidity. Only monitoring deaths at a national level may hide the effect of the pandemic on the regional level.", "doi": "10.1093/eurpub/ckaa218", "pmid": "33169145", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "5968985"}, {"db": "pmc", "key": "PMC7717265"}], "notes": [], "created": "2021-06-14T06:37:23.104Z", "modified": "2021-09-23T05:11:34.318Z"}, {"entity": "publication", "iuid": "302719fae97442a58c88e35043be6d72", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/302719fae97442a58c88e35043be6d72.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/302719fae97442a58c88e35043be6d72"}}, "title": "Early humoral defense: Contributing to confining Covid-19 to conducting airways?", "authors": [{"family": "Persson", "given": "Carl", "initials": "C"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "Scand J Immunol", "issn": "1365-3083", "volume": null, "issue": null, "pages": "e13024", "issn-l": null}, "abstract": "Early airway responses to Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection are of interest since they could decide whether Coronavirus disease-19 (Covid-19) will proceed to life-threatening pulmonary disease stages. Here I discuss endothelial-epithelial co-operative in vivo-responses producing first-line, humoral innate defense opportunities in human airways. The pseudostratified epithelium of human nasal and tracheobronchial airways are prime sites of exposure and infection by SARS-CoV-2. Just beneath the epithelium runs a profuse systemic microcirculation. Its postcapillary venules respond conspicuously to mucosal challenges with autacoids, allergens, and microbes, and to mere loss of epithelium. By active venular endothelial gap formation, followed by transient yielding of epithelial junctions, non-sieved plasma macromolecules move from the microcirculation to the mucosal surface. Hence, plasma-derived protein cascade systems and antimicrobial peptides would have opportunity to operate jointly on an unperturbed mucosal lining. Similarly, a plasma-derived, dynamic gel protects sites of epithelial sloughing-regeneration. Precision for this indiscriminate humoral molecular response lies in restricted location and well-regulated duration of plasma exudation. Importantly, the endothelial responsiveness of the airway microcirculation differs distinctly from the relatively non-responsive, low-pressure pulmonary microcirculation that non-specifically, almost irreversibly, leaks plasma in life-threatening Covid-19. Observations in humans of infections with rhinovirus, corona virus 229E, and influenza A and B, support a general but individually variable early occurrence of plasma exudation in human infected nasal and tracheobronchial airways. Investigations are warranted to elucidate roles of host- and drug-induced airways plasma exudation in restriction of viral infection and, specifically, whether it contributes to variable disease-responses following exposure to SARS-CoV-2.", "doi": "10.1111/sji.13024", "pmid": "33523532", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-04T18:24:22.565Z", "modified": "2021-02-04T18:24:22.587Z"}, {"entity": "publication", "iuid": "1491b4b81ef944f4b9b00b9235cbd797", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1491b4b81ef944f4b9b00b9235cbd797.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1491b4b81ef944f4b9b00b9235cbd797"}}, "title": "Decay of SARS-CoV-2 RNA along the wastewater treatment outfitted with Upflow Anaerobic Sludge Blanket (UASB) system evaluated through two sample concentration techniques.", "authors": [{"family": "Kumar", "given": "Manish", "initials": "M"}, {"family": "Kuroda", "given": "Keisuke", "initials": "K"}, {"family": "Patel", "given": "Arbind Kumar", "initials": "AK"}, {"family": "Patel", "given": "Nidhi", "initials": "N"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Joshi", "given": "Madhvi", "initials": "M"}, {"family": "Joshi", "given": "Chaitanya G", "initials": "CG"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "issn-l": "0048-9697", "volume": "754", "issue": null, "pages": "142329"}, "abstract": "For the first time, we present, i) an account of decay in the genetic material loading of SARS-CoV-2 during Upflow Anaerobic Sludge Blanket (UASB) treatment of wastewater, and ii) comparative evaluation of polyethylene glycol (PEG), and ultrafiltration as virus concentration methods from wastewater for the quantification of SARS-CoV-2 genes. The objectives were achieved through tracking of SARS-CoV-2 genetic loadings i.e. ORF1ab, N and S protein genes on 8th and 27th May 2020 along the wastewater treatment plant (106000 m 3 million liters per day) equipped with UASB system in Ahmedabad, India. PEG method performed better in removing materials inhibiting RT-qPCR for SARS-CoV-2 gene detection from the samples, as evident from constant and lower CT values of control (MS2). Using the PEG method, we found a reduction >1.3 log10 reduction in SARS-CoV-2 RNA abundance during UASB treatment, and the RNA was not detected at all in the final effluent. The study implies that i) conventional wastewater treatment systems is effective in SARS-CoV-2 RNA removal, and ii) UASB system significantly reduces SARS-CoV-2 genetic loadings. Finally, PEG method is recommended for better sensitivity and inhibition removal during SARS-CoV-2 RNA quantification in wastewater.", "doi": "10.1016/j.scitotenv.2020.142329", "pmid": "33254951", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(20)35858-7"}], "notes": [], "created": "2020-12-03T08:20:09.557Z", "modified": "2021-02-26T08:46:12.935Z"}, {"entity": "publication", "iuid": "098cd3e85b5d489bbab5e2dbb82d2f33", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/098cd3e85b5d489bbab5e2dbb82d2f33.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/098cd3e85b5d489bbab5e2dbb82d2f33"}}, "title": "Assessment of Suicide in Japan During the COVID-19 Pandemic vs Previous Years.", "authors": [{"family": "Sakamoto", "given": "Haruka", "initials": "H"}, {"family": "Ishikane", "given": "Masahiro", "initials": "M"}, {"family": "Ghaznavi", "given": "Cyrus", "initials": "C"}, {"family": "Ueda", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "issn-l": null, "volume": "4", "issue": "2", "pages": "e2037378"}, "abstract": "There are concerns that suicide rates may have increased during the coronavirus disease 2019 (COVID-19) pandemic.\r\n\r\nTo assess whether suicide rates in Japan increased in April through November 2020 compared with previous years.\r\n\r\nThis cross-sectional study used national data obtained from the Ministry of Health, Labor and Welfare from 2016 to 2020 on the monthly number of individuals who died of suicide in Japan from January to November of 2016 to 2020.\r\n\r\n2020 vs previous years.\r\n\r\nThe main outcome was monthly suicide rates, calculated as the number of individuals who died of suicide divided by the total population. A difference-in-difference regression model was used to estimate the change in monthly suicide rates in April to November 2020 vs these months in 2016 to 2019.\r\n\r\nAnalyses included 90 048 individuals (61 366 [68.1%] men) who died of suicide from 2016 to 2020. The difference-in-difference analysis of men showed that there was no increase in suicide rates from April through September 2020 compared with these months in 2016 to 2019, but that suicide rates were increased in October (difference-in-difference, 0.40 [95% CI, 0.14 to 0.67] suicide deaths per 100 000 population) and November (difference-in-difference, 0.34 [95% CI, 0.07 to 0.60] suicide deaths per 100 000 population). Among women, suicide rates in 2020 compared with 2016 to 2019 increased in July (difference-in-difference, 0.24 [95% CI, 0.09 to 0.38] suicide deaths per 100 000 population), August (difference-in-difference, 0.30 [95% CI, 0.16 to 0.45] suicide deaths per 100 000 population), September (difference-in-difference, 0.29 [95% CI, 0.15 to 0.44] suicide deaths per 100 000 population), October (difference-in-difference, 0.62 [95% CI, 0.48 to 0.77] suicide deaths per 100 000 population), and November (difference-in-difference, 0.29 [95% CI, 0.15 to 0.44] suicide deaths per 100 000 population). In secondary analyses in which the suicide rates of 2020 were compared with the expected rates based on trends from 2011 to 2019, the increases in suicide rates were most pronounced among men aged younger than 30 years (eg, November: observed vs expected rate ratio [RR], 1.48 [95% CI, 1.26-1.71]) and women aged younger than 30 years (eg, October: observed vs expected RR, 2.14 [95% CI, 1.76 to 2.52]) and 30 to 49 years (eg, October: observed vs expected RR, 2.30 [95% CI, 2.01 to 2.58]).\r\n\r\nThese findings suggest that compared with previous years, suicide rates in Japan in 2020 increased in October and November for men and in July through November for women.", "doi": "10.1001/jamanetworkopen.2020.37378", "pmid": "33528554", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "2775740"}], "notes": [], "created": "2021-02-04T18:23:24.857Z", "modified": "2021-06-18T11:16:04.908Z"}, {"entity": "publication", "iuid": "ddbf17922ce142488599dc803aded789", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ddbf17922ce142488599dc803aded789.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ddbf17922ce142488599dc803aded789"}}, "title": "Risk of Severe Covid-19 in Patients with Celiac Disease: A Population-Based Cohort Study", "authors": [{"family": "Lebwohl", "given": "Benjamin", "initials": "B"}, {"family": "Larsson", "given": "Emma", "initials": "E"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Roelstraete", "given": "Bjorn", "initials": "B"}, {"family": "Murray", "given": "Joseph A", "initials": "JA"}, {"family": "Green", "given": "Peter HR", "initials": "PH"}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "journal-article", "published": "2021-02-00", "journal": {"title": "CLEP", "issn": "1179-1349", "volume": "Volume 13", "issue": null, "pages": "121-130", "issn-l": null}, "abstract": null, "doi": "10.2147/clep.s294391", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-25T12:30:09.922Z", "modified": "2021-02-26T08:47:00.236Z"}, {"entity": "publication", "iuid": "1d63ea6dcd2544f9b0421a69d04ab013", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d63ea6dcd2544f9b0421a69d04ab013.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d63ea6dcd2544f9b0421a69d04ab013"}}, "title": "Reflections on Virtual Care for Chronic Conditions During the COVID-19 Pandemic.", "authors": [{"family": "Wittmeier", "given": "Kristy D M", "initials": "KDM"}, {"family": "Protudjer", "given": "Jennifer L P", "initials": "JLP"}, {"family": "Wicklow", "given": "Brandy A", "initials": "BA"}], "type": "editorial", "published": "2021-02-00", "journal": {"title": "Can J Diabetes", "issn": "2352-3840", "volume": "45", "issue": "1", "pages": "1-2", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jcjd.2020.11.013", "pmid": "33500126", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1499-2671(20)30468-8"}], "notes": [], "created": "2021-01-29T15:20:38.702Z", "modified": "2021-01-29T15:20:38.727Z"}, {"entity": "publication", "iuid": "6cad7393922b4bdab063ef4a5b4e2db5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6cad7393922b4bdab063ef4a5b4e2db5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6cad7393922b4bdab063ef4a5b4e2db5"}}, "title": "Presymptomatic viral shedding and infective ability of SARS-CoV-2; a case report.", "authors": [{"family": "Nissen", "given": "Karolina", "initials": "K"}, {"family": "Hagbom", "given": "Marie", "initials": "M"}, {"family": "Krambrich", "given": "Janina", "initials": "J"}, {"family": "Akaberi", "given": "Dario", "initials": "D"}, {"family": "Sharma", "given": "Sumit", "initials": "S"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Svensson", "given": "Lennart", "initials": "L"}, {"family": "Bondeson", "given": "K\u00e5re", "initials": "K"}, {"family": "Salaneck", "given": "Erik", "initials": "E"}], "type": "case reports", "published": "2021-02-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "issn-l": null, "volume": "7", "issue": "2", "pages": "e06328"}, "abstract": "Possible pre- or asymptomatic transmission has been reported, both from SARS-CoV and from MERS-CoV outbreaks, although this appears to be uncommon. In contrast, during the COVID-19 pandemic, an increasing number of studies and case reports indicate that pre- or asymptomatic transmission of SARS-CoV-2 is not only possible but also occurs frequently. We report repeated rRT-PCR detection of SARS-CoV-2 in a health care worker and demonstrate infective ability up to three days prior to mild COVID-19 symptoms. rRT-PCR indicated high viral levels approximately three days after exposure. Viral samples collected one and three days prior to symptoms exhibited infectivity on Vero E6 cells, confirmed by detection of double-stranded RNA by immunofluorescence, assessment of cytopathic effect (CPE) and rRT-PCR. SARS-CoV-2 specific IgM and IgG antibodies were detected by day 9 and 15, respectively, after symptom onset. We propose that this provides evidence for potential early presymptomatic transmission of SARS-CoV-2 and that infectivity may be manifest shortly after exposure.", "doi": "10.1016/j.heliyon.2021.e06328", "pmid": "33644482", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)00433-3"}, {"db": "pmc", "key": "PMC7894094"}], "notes": [], "created": "2021-03-02T06:53:25.256Z", "modified": "2021-06-18T11:15:39.188Z"}, {"entity": "publication", "iuid": "69841acb8a304e629226b7c50efe0667", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69841acb8a304e629226b7c50efe0667.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69841acb8a304e629226b7c50efe0667"}}, "title": "Point of view on the vaccination against COVID-19 in patients with autoimmune inflammatory rheumatic diseases.", "authors": [{"family": "Furer", "given": "Victoria", "initials": "V", "orcid": "0000-0001-5193-4207", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/17050dc675254cd59533c6568f60db38.json"}}, {"family": "Rondaan", "given": "Christien", "initials": "C", "orcid": "0000-0002-4558-1270", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a1288a4e4e54e2380de0649962e0322.json"}}, {"family": "Agmon-Levin", "given": "Nancy", "initials": "N"}, {"family": "van Assen", "given": "Sander", "initials": "S"}, {"family": "Bijl", "given": "Marc", "initials": "M"}, {"family": "Kapetanovic", "given": "Meliha Crnkic", "initials": "MC"}, {"family": "de Thurah", "given": "Annette", "initials": "A", "orcid": "0000-0003-0103-4328", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2450d24c34eb4edeb270e0b576635a12.json"}}, {"family": "Mueller-Ladner", "given": "Ulf", "initials": "U"}, {"family": "Paran", "given": "Daphna", "initials": "D"}, {"family": "Schreiber", "given": "Karen", "initials": "K"}, {"family": "Warnatz", "given": "Klaus", "initials": "K"}, {"family": "Wulffraat", "given": "Nico M", "initials": "NM"}, {"family": "Elkayam", "given": "Ori", "initials": "O"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "RMD Open", "issn": "2056-5933", "volume": "7", "issue": "1", "pages": "e001594", "issn-l": null}, "abstract": "In view of the COVID-19 pandemic, there is an unmet clinical need for the guidelines on vaccination of patients with autoimmune inflammatory rheumatic diseases (AIIRD). This position paper summarises the current data on COVID-19 infection in patients with AIIRD and development of vaccines against COVID-19, discusses the aspects of efficacy and safety of vaccination, and proposes preliminary considerations on vaccination against COVID-19 in patients with AIIRD, mainly based on the expert opinion and knowledge on the use of other vaccines in this population of patients.", "doi": "10.1136/rmdopen-2021-001594", "pmid": "33627440", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "rmdopen-2021-001594"}, {"db": "pmc", "key": "PMC7907831"}], "notes": [], "created": "2021-02-25T14:57:13.800Z", "modified": "2021-07-14T07:52:36.535Z"}, {"entity": "publication", "iuid": "487865ba9e4b446b9097b0d17ff1ecb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/487865ba9e4b446b9097b0d17ff1ecb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/487865ba9e4b446b9097b0d17ff1ecb1"}}, "title": "Persistence of IgG response to SARS-CoV-2.", "authors": [{"family": "Duysburgh", "given": "Els", "initials": "E"}, {"family": "Mortgat", "given": "Laure", "initials": "L"}, {"family": "Barbezange", "given": "Cyril", "initials": "C"}, {"family": "Dierick", "given": "Katelijne", "initials": "K"}, {"family": "Fischer", "given": "Natalie", "initials": "N"}, {"family": "Heyndrickx", "given": "Leo", "initials": "L"}, {"family": "Hutse", "given": "Veronik", "initials": "V"}, {"family": "Thomas", "given": "Isabelle", "initials": "I"}, {"family": "Van Gucht", "given": "Steven", "initials": "S"}, {"family": "Vuylsteke", "given": "Bea", "initials": "B"}, {"family": "Ari\u00ebn", "given": "Kevin K", "initials": "KK"}, {"family": "Desombere", "given": "Isabelle", "initials": "I"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "issn-l": null, "volume": "21", "issue": "2", "pages": "163-164"}, "abstract": null, "doi": "10.1016/S1473-3099(20)30943-9", "pmid": "33341124", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(20)30943-9"}, {"db": "pmc", "key": "PMC7833610"}], "notes": [], "created": "2021-01-10T18:08:16.831Z", "modified": "2021-07-14T07:49:21.276Z"}, {"entity": "publication", "iuid": "a4dcb004fb8140fbb690fb73057e327e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a4dcb004fb8140fbb690fb73057e327e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a4dcb004fb8140fbb690fb73057e327e"}}, "title": "Pediatric COVID-19 Cases Prelockdown and Postlockdown in Italy.", "authors": [{"family": "Bellino", "given": "Stefania", "initials": "S"}, {"family": "Rota", "given": "Maria Cristina", "initials": "MC"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Mateo Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Punzo", "given": "Ornella", "initials": "O"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Villani", "given": "Alberto", "initials": "A"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "COVID-19 Working Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Pediatrics", "issn": "1098-4275", "volume": "147", "issue": "2", "issn-l": null}, "abstract": null, "doi": "10.1542/peds.2020-035238", "pmid": "33154154", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "peds.2020-035238"}], "notes": [], "created": "2021-02-10T18:54:40.193Z", "modified": "2021-02-26T08:47:00.137Z"}, {"entity": "publication", "iuid": "2f959e159f0a4064b0bf49d2d8f84427", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2f959e159f0a4064b0bf49d2d8f84427.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2f959e159f0a4064b0bf49d2d8f84427"}}, "title": "Online health survey research during COVID-19", "authors": [{"family": "Hlatshwako", "given": "Takhona G", "initials": "TG"}, {"family": "Shah", "given": "Sonam J", "initials": "SJ"}, {"family": "Kosana", "given": "Priya", "initials": "P"}, {"family": "Adebayo", "given": "Emmanuel", "initials": "E"}, {"family": "Hendriks", "given": "Jacqueline", "initials": "J"}, {"family": "Larsson", "given": "Elin C", "initials": "EC"}, {"family": "Hensel", "given": "Devon J", "initials": "DJ"}, {"family": "Erausquin", "given": "Jennifer Toller", "initials": "JT"}, {"family": "Marks", "given": "Michael", "initials": "M"}, {"family": "Michielsen", "given": "Kristien", "initials": "K"}, {"family": "Saltis", "given": "Hanna", "initials": "H"}, {"family": "Francis", "given": "Joel M", "initials": "JM"}, {"family": "Wouters", "given": "Edwin", "initials": "E"}, {"family": "Tucker", "given": "Joseph D", "initials": "JD"}], "type": "journal-article", "published": "2021-02-00", "journal": {"title": "The Lancet Digital Health", "issn": "2589-7500", "issn-l": null, "volume": "3", "issue": "2", "pages": "e76-e77"}, "abstract": null, "doi": "10.1016/s2589-7500(21)00002-9", "pmid": "33509387", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-29T15:11:39.497Z", "modified": "2021-02-15T19:17:59.351Z"}, {"entity": "publication", "iuid": "8662c05a2e6c4dab89413bfd6652c32e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8662c05a2e6c4dab89413bfd6652c32e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8662c05a2e6c4dab89413bfd6652c32e"}}, "title": "Lingonberry polyphenols: Potential SARS-CoV-2 inhibitors as nutraceutical tools?", "authors": [{"family": "P\u00e4rn\u00e4nen", "given": "Pirjo", "initials": "P"}, {"family": "L\u00e4hteenm\u00e4ki", "given": "Hanna", "initials": "H"}, {"family": "R\u00e4is\u00e4nen", "given": "Ismo", "initials": "I"}, {"family": "Tervahartiala", "given": "Taina", "initials": "T"}, {"family": "Sorsa", "given": "Timo", "initials": "T"}], "type": "letter", "published": "2021-02-00", "journal": {"title": "Physiol Rep", "issn": "2051-817X", "volume": "9", "issue": "3", "pages": "e14741", "issn-l": null}, "abstract": "Proposed pathway of the effect of lingonberry polyphenols on oral microbial (viral) load reduction and consequent beneficial local and systemic (respiratory tract) anti-inflammatory and antimicrobial/antiviral effects.", "doi": "10.14814/phy2.14741", "pmid": "33527774", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-04T18:23:55.661Z", "modified": "2021-02-04T18:23:55.683Z"}, {"entity": "publication", "iuid": "fd6a374bb2da4ca3b85dacb8f68a68a5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fd6a374bb2da4ca3b85dacb8f68a68a5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fd6a374bb2da4ca3b85dacb8f68a68a5"}}, "title": "Leveraging epidemiological principles to evaluate Sweden's COVID-19 response.", "authors": [{"family": "Baral", "given": "Stefan", "initials": "S"}, {"family": "Chandler", "given": "Rebecca", "initials": "R"}, {"family": "Prieto", "given": "Ruth Gil", "initials": "RG"}, {"family": "Gupta", "given": "Sunetra", "initials": "S"}, {"family": "Mishra", "given": "Sharmistha", "initials": "S"}, {"family": "Kulldorff", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Ann Epidemiol", "issn": "1873-2585", "volume": "54", "issue": null, "pages": "21-26", "issn-l": null}, "abstract": "In the response to COVID-19, countries have implemented response strategies along a continuum of population- and venue-level specificity ranging from suppression to mitigation strategies. Suppression strategies generally include population-wide shelter-in-place mandates or lockdowns, closure of nonessential physical venues, travel bans, testing and contact tracing, and quarantines. Sweden followed a mitigation strategy focused on risk-tailored approaches to mitigate specific acquisition risks among the elderly, minimizing the disruption to education and the delivery of other health care services, and recommendations for social distancing to minimize the disease burden. To date, Sweden has reported higher case counts and attributable mortality than other Scandinavian countries and lower than other Northern European countries. However, there are several limitations with comparison given heterogeneity in testing strategies, suspected and confirmed case definitions, and assessment of attributable mortality. The decisions in Sweden also reflect social priorities such as equity being a foundational principle of Swedish social systems. Consistently, in-person education for those aged less than 16 years continued throughout. Notably, the mitigation strategy did not eliminate the inequitable impacts of COVID-19 cases and mortality in Sweden with higher-exposure and generally lower-income occupations being associated with higher risks intersecting with these communities often residing in more dense multigenerational households. From January 1 to November 15, there has been a 1.8% increase in all-cause mortality in 2020 compared with the average of 2015-2019, representing an excess of 14.3 deaths per 100,000 population. However, the final assessment of excess deaths in Sweden in 2020 including stratification by age and integration of secular trends can only be calculated in the coming years. In response to increasing cases in the fall of 2020, Sweden has continued to leverage business-oriented regulations and public-oriented guidelines for social distancing rather than police-enforced mandates. Ultimately, pandemics present no winners. Countries have implemented a range of different COVID-19 prevention and mitigation strategies responsive to their own priorities and legal systems including equity and the balancing of competing health priorities. Given these varied approaches, countries that pursued elimination, suppression, or mitigation strategies can collaboratively learn from both successes and challenges of the different strategies to inform COVID-19 and future pandemic responses.", "doi": "10.1016/j.annepidem.2020.11.005", "pmid": "33242596", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7682427"}, {"db": "pii", "key": "S1047-2797(20)30413-0"}], "notes": [], "created": "2020-11-30T07:46:01.828Z", "modified": "2023-01-13T13:27:50.907Z"}, {"entity": "publication", "iuid": "7d8d997669864c078e5036277c77f2c4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d8d997669864c078e5036277c77f2c4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d8d997669864c078e5036277c77f2c4"}}, "title": "Just allocation of COVID-19 vaccines.", "authors": [{"family": "Herlitz", "given": "Anders", "initials": "A"}, {"family": "Lederman", "given": "Zohar", "initials": "Z"}, {"family": "Miller", "given": "Jennifer", "initials": "J"}, {"family": "Fleurbaey", "given": "Marc", "initials": "M"}, {"family": "Venkatapuram", "given": "Sridhar", "initials": "S"}, {"family": "Atuire", "given": "Caesar", "initials": "C"}, {"family": "Eckenwiler", "given": "Lisa", "initials": "L"}, {"family": "Hassoun", "given": "Nicole", "initials": "N"}], "type": "editorial", "published": "2021-02-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "2", "issn-l": "2059-7908"}, "abstract": null, "doi": "10.1136/bmjgh-2020-004812", "pmid": "33589419", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-004812"}], "notes": [], "created": "2021-02-17T14:52:59.770Z", "modified": "2021-02-17T14:53:17.075Z"}, {"entity": "publication", "iuid": "9b83ecfd2cf74c0fb5506f4188b70b13", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b83ecfd2cf74c0fb5506f4188b70b13.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b83ecfd2cf74c0fb5506f4188b70b13"}}, "title": "Indirect acute effects of the COVID-19 pandemic on physical and mental health in the UK: a population-based study", "authors": [{"family": "Mansfield", "given": "Kathryn E", "initials": "KE"}, {"family": "Mathur", "given": "Rohini", "initials": "R"}, {"family": "Tazare", "given": "John", "initials": "J"}, {"family": "Henderson", "given": "Alasdair D", "initials": "AD"}, {"family": "Mulick", "given": "Amy R", "initials": "AR"}, {"family": "Carreira", "given": "Helena", "initials": "H"}, {"family": "Matthews", "given": "Anthony A", "initials": "AA"}, {"family": "Bidulka", "given": "Patrick", "initials": "P"}, {"family": "Gayle", "given": "Alicia", "initials": "A"}, {"family": "Forbes", "given": "Harriet", "initials": "H"}, {"family": "Cook", "given": "Sarah", "initials": "S"}, {"family": "Wong", "given": "Angel Y S", "initials": "AYS"}, {"family": "Strongman", "given": "Helen", "initials": "H"}, {"family": "Wing", "given": "Kevin", "initials": "K"}, {"family": "Warren-Gash", "given": "Charlotte", "initials": "C"}, {"family": "Cadogan", "given": "Sharon L", "initials": "SL"}, {"family": "Smeeth", "given": "Liam", "initials": "L"}, {"family": "Hayes", "given": "Joseph F", "initials": "JF"}, {"family": "Quint", "given": "Jennifer K", "initials": "JK"}, {"family": "McKee", "given": "Martin", "initials": "M"}, {"family": "Langan", "given": "Sin\u00e9ad M", "initials": "SM"}], "type": "journal-article", "published": "2021-02-00", "journal": {"title": "The Lancet Digital Health", "issn": "2589-7500", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/s2589-7500(21)00017-0", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-22T14:10:45.560Z", "modified": "2021-06-18T11:41:19.983Z"}, {"entity": "publication", "iuid": "7a750b50ba814141b855b6ad3efb4c8e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a750b50ba814141b855b6ad3efb4c8e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a750b50ba814141b855b6ad3efb4c8e"}}, "title": "Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients.", "authors": [{"family": "B\u00fclow Anderberg", "given": "Sara", "initials": "S"}, {"family": "Luther", "given": "Tomas", "initials": "T"}, {"family": "Berglund", "given": "Malin", "initials": "M"}, {"family": "Larsson", "given": "Rolf", "initials": "R"}, {"family": "Rubertsson", "given": "Sten", "initials": "S"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Cytokine", "issn": "1043-4666", "issn-l": null, "volume": "138", "issue": null, "pages": "155389"}, "abstract": "The infection caused by SARS CoV-2 has been postulated to induce a cytokine storm syndrome that results in organ failure and even death in a considerable number of patients. However, the inflammatory response in Corona virus disease-19 (Covid-19) and its potential to cause collateral organ damage has not been fully elucidated to date. This study aims to characterize the acute cytokine response in a cohort of critically ill Covid-19 patients.\r\n\r\n24 adults with PCR-confirmed Covid-19 were included at time of admission to intensive care a median of eleven days after initial symptoms. Eleven adult patients admitted for elective abdominal surgery with preoperative plasma samples served as controls. All patients were included after informed consent was obtained. 27 cytokines were quantified in plasma. The expression of inflammatory mediators was then related to routine inflammatory markers, SAPS3, SOFA score, organ failure and 30-day mortality.\r\n\r\nA general increase in cytokine expression was observed in all Covid-19 patients. A strong correlation between respiratory failure and IL-1ra, IL-4, IL-6, IL-8 and IP-10 expression was observed. Acute kidney injury development correlated well with increased levels of IL-1ra, IL-6, IL-8, IL-17a, IP-10 and MCP-1. Generally, the cohort demonstrated weaker correlations between cytokine expression and 30-day mortality out of which IL-8 showed the strongest signal in terms of mortality.\r\n\r\nThe present study found that respiratory failure, acute kidney injury and 30-day mortality in critically ill Covid-19 patients are associated with moderate increases of a broad range of inflammatory mediators at time of admission.", "doi": "10.1016/j.cyto.2020.155389", "pmid": "33348065", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1043-4666(20)30405-1"}, {"db": "pmc", "key": "PMC7833204"}], "notes": [], "created": "2020-12-22T11:23:41.897Z", "modified": "2021-06-11T14:26:41.341Z"}, {"entity": "publication", "iuid": "c5b8fd169aca45b880a478c279cf0888", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5b8fd169aca45b880a478c279cf0888.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5b8fd169aca45b880a478c279cf0888"}}, "title": "EHA/ESMO Clinical Practice Guidelines for the Management of Malignant Lymphoma: Recommendations for the Second Phase of the COVID-19 Pandemic.", "authors": [{"family": "Dreyling", "given": "Martin", "initials": "M"}, {"family": "Aurer", "given": "Igor", "initials": "I"}, {"family": "Federico", "given": "Massimo", "initials": "M"}, {"family": "Jerkeman", "given": "Mats", "initials": "M"}, {"family": "Kersten", "given": "Marie Jose", "initials": "MJ"}, {"family": "Linton", "given": "Kim", "initials": "K"}, {"family": "Mey", "given": "Ulrich", "initials": "U"}, {"family": "Tilly", "given": "Herve", "initials": "H"}, {"family": "Buske", "given": "Christian", "initials": "C"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Hemasphere", "issn": "2572-9241", "volume": "5", "issue": "2", "pages": "e529", "issn-l": null}, "abstract": null, "doi": "10.1097/HS9.0000000000000529", "pmid": "33880434", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8051991"}], "notes": [], "created": "2021-04-23T04:38:11.381Z", "modified": "2021-04-23T04:38:11.403Z"}, {"entity": "publication", "iuid": "3632e818c24f4aaf9db49ba11d5b8c07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3632e818c24f4aaf9db49ba11d5b8c07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3632e818c24f4aaf9db49ba11d5b8c07"}}, "title": "Does antipsychotic use mediate the effect of psychiatric disorders on COVID-19? - Authors' reply.", "authors": [{"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Chen", "given": "Wenwen", "initials": "W"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Lancet Healthy Longev", "issn": "2666-7568", "volume": "2", "issue": "2", "pages": "e65", "issn-l": null}, "abstract": null, "doi": "10.1016/S2666-7568(21)00007-6", "pmid": "33665643", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2666-7568(21)00007-6"}, {"db": "pmc", "key": "PMC7906648"}], "notes": [], "created": "2021-03-06T10:11:40.785Z", "modified": "2021-03-06T10:11:40.793Z"}, {"entity": "publication", "iuid": "2ec0095a0ee14c30aea469610f0c14ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ec0095a0ee14c30aea469610f0c14ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ec0095a0ee14c30aea469610f0c14ef"}}, "title": "Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19.", "authors": [{"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/305bca9e5c6c423898c272bf06ce2f2a.json"}}, {"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f28f2f6ac9648629c2d2de92fe7bb59.json"}}, {"family": "Rosell", "given": "Axel", "initials": "A", "orcid": "0000-0001-6280-0562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4da18c480a2d4c80ad6c7d1f97bbf917.json"}}, {"family": "Aguilera", "given": "Katherina", "initials": "K"}, {"family": "Parv", "given": "Kristel", "initials": "K", "orcid": "0000-0002-1238-9338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c21024fbb7f447db8879b36373e00bae.json"}}, {"family": "von Meijenfeldt", "given": "Fien A", "initials": "FA", "orcid": "0000-0003-0274-2414", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76b5cb67f6e243459441f06d41f0816c.json"}}, {"family": "Lisman", "given": "Ton", "initials": "T", "orcid": "0000-0002-3503-7140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7431e810d13c443ca5dacbf5d368e60b.json"}}, {"family": "Mackman", "given": "Nigel", "initials": "N", "orcid": "0000-0002-9170-7700", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/979eb3bfd39f407ba1f0359140d215fd.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1345-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a53a433db6f04a458e3d420f0c9995c5.json"}}, {"family": "Phillipson", "given": "Mia", "initials": "M", "orcid": "0000-0002-2387-0266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/614a4a6f69204c6287a81a79a1a7a8f1.json"}}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Arterioscler Thromb Vasc Biol", "issn": "1524-4636", "issn-l": null, "volume": "41", "issue": "2", "pages": "988-994"}, "abstract": "The full spectrum of coronavirus disease 2019 (COVID-19) infection ranges from asymptomatic to acute respiratory distress syndrome, characterized by hyperinflammation and thrombotic microangiopathy. The pathogenic mechanisms are poorly understood, but emerging evidence suggest that excessive neutrophil extracellular trap (NET) formation plays a key role in COVID-19 disease progression. Here, we evaluate if circulating markers of NETs are associated with COVID-19 disease severity and clinical outcome, as well as to markers of inflammation and in vivo coagulation and fibrinolysis. Approach and Results: One hundred six patients with COVID-19 with moderate to severe disease were enrolled shortly after hospital admission and followed for 4 months. Acute and convalescent plasma samples as well as plasma samples from 30 healthy individuals were assessed for markers of NET formation: citrullinated histone H3, cell-free DNA, NE (neutrophil elastase). We found that all plasma levels of NET markers were elevated in patients with COVID-19 relative to healthy controls, that they were associated with respiratory support requirement and short-term mortality, and declined to those found in healthy individuals 4 months post-infection. The levels of the NET markers also correlated with white blood cells, neutrophils, inflammatory cytokines, and C-reactive protein, as well as to markers of in vivo coagulation, fibrinolysis, and endothelial damage.\n\nOur findings suggest a role of NETs in COVID-19 disease progression, implicating their contribution to an immunothrombotic state. Further, we observed an association between circulating markers of NET formation and clinical outcome, demonstrating a potential role of NET markers in clinical decision-making, as well as for NETs as targets for novel therapeutic interventions in COVID-19.", "doi": "10.1161/ATVBAHA.120.315267", "pmid": "33267662", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7837697"}], "notes": [], "created": "2020-12-04T09:03:17.375Z", "modified": "2022-02-14T15:55:21.457Z"}, {"entity": "publication", "iuid": "5f2c59b02c4d48a983071ac076b60ca1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f2c59b02c4d48a983071ac076b60ca1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f2c59b02c4d48a983071ac076b60ca1"}}, "title": "COVID-19: investing in country capacity to bridge science, policy and action.", "authors": [{"family": "Kuchenm\u00fcller", "given": "Tanja", "initials": "T"}, {"family": "Reeder", "given": "John C", "initials": "JC"}, {"family": "Reveiz", "given": "Ludovic", "initials": "L"}, {"family": "Tomson", "given": "Goran", "initials": "G"}, {"family": "El-Jardali", "given": "Fadi", "initials": "F"}, {"family": "Lavis", "given": "John N", "initials": "JN"}, {"family": "Rashidian", "given": "Arash", "initials": "A"}, {"family": "Reinap", "given": "Marge", "initials": "M"}, {"family": "Grove", "given": "John T", "initials": "JT"}, {"family": "Swaminathan", "given": "Soumya", "initials": "S"}], "type": "editorial", "published": "2021-02-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "issn-l": "2059-7908", "volume": "6", "issue": "2", "pages": null}, "abstract": null, "doi": "10.1136/bmjgh-2021-005012", "pmid": "33597281", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-005012"}], "notes": [], "created": "2021-02-19T06:20:07.200Z", "modified": "2021-02-19T06:20:17.002Z"}, {"entity": "publication", "iuid": "624e15eacaa642b18cc1953db10887fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/624e15eacaa642b18cc1953db10887fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/624e15eacaa642b18cc1953db10887fd"}}, "title": "COVID-19: Opportunities for interdisciplinary research to improve care for older people in Sweden.", "authors": [{"family": "Baxter", "given": "Rebecca", "initials": "R", "orcid": "0000-0001-6595-6298", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/446ab62637de405fa4042d961cedbe36.json"}}, {"family": "Jemberie", "given": "Wossenseged Birhane", "initials": "WB", "orcid": "0000-0002-4378-6803", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e7b6e3bb364489288767124c08f43e9.json"}}, {"family": "Li", "given": "Xia", "initials": "X"}, {"family": "Naseer", "given": "Mahwish", "initials": "M"}, {"family": "Pauelsen", "given": "Mascha", "initials": "M", "orcid": "0000-0002-2510-7571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/461406e7a70a44168b097af43b4052e9.json"}}, {"family": "Shebehe", "given": "Jacques", "initials": "J", "orcid": "0000-0002-0044-0781", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/361987c728f64fbe95ef1c303417aeba.json"}}, {"family": "Viklund", "given": "Emilia W E", "initials": "EWE", "orcid": "0000-0002-5852-1381", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be19480279de4195b28af1bfe2c692ff.json"}}, {"family": "Xia", "given": "Xin", "initials": "X"}, {"family": "Zulka", "given": "Linn Elena", "initials": "LE"}, {"family": "Badache", "given": "Andreea", "initials": "A"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "volume": "49", "issue": "1", "pages": "29-32", "issn-l": "1403-4948"}, "abstract": "The emergence of COVID-19 has changed the world as we know it, arguably none more so than for older people. In Sweden, the majority of COVID-19-related fatalities have been among people aged \u2a7e70 years, many of whom were receiving health and social care services. The pandemic has illuminated aspects within the care continuum requiring evaluative research, such as decision-making processes, the structure and organisation of care, and interventions within the complex public-health system. This short communication highlights several key areas for future interdisciplinary and multi-sectorial collaboration to improve health and social care services in Sweden. It also underlines that a valid, reliable and experiential evidence base is the sine qua non for evaluative research and effective public-health systems.", "doi": "10.1177/1403494820969544", "pmid": "33161880", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7859561"}], "notes": [], "created": "2020-11-27T10:06:14.801Z", "modified": "2023-01-13T13:42:48.947Z"}, {"entity": "publication", "iuid": "7aaaa58539d848c588572b55511cd93a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7aaaa58539d848c588572b55511cd93a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7aaaa58539d848c588572b55511cd93a"}}, "title": "An analytical study of drug utilization, disease progression, and adverse events among 165 COVID-19 patients.", "authors": [{"family": "Sun", "given": "Feng", "initials": "F"}, {"family": "Kou", "given": "Hao", "initials": "H"}, {"family": "Wang", "given": "Shengfeng", "initials": "S"}, {"family": "Lu", "given": "Yun", "initials": "Y"}, {"family": "Zhao", "given": "Houyu", "initials": "H"}, {"family": "Li", "given": "Wenjing", "initials": "W"}, {"family": "Zhou", "given": "Qingxin", "initials": "Q"}, {"family": "Jiang", "given": "Qiaoli", "initials": "Q"}, {"family": "Cheng", "given": "Yinchu", "initials": "Y"}, {"family": "Yang", "given": "Kun", "initials": "K"}, {"family": "Zhuo", "given": "Lin", "initials": "L"}, {"family": "Xu", "given": "Yang", "initials": "Y"}, {"family": "Wu", "given": "Dongfang", "initials": "D"}, {"family": "Zhan", "given": "Siyan", "initials": "S"}, {"family": "Cheng", "given": "Hong", "initials": "H"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Ann Transl Med", "issn": "2305-5839", "volume": "9", "issue": "4", "pages": "306", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) epidemic has lasted for nearly 4 months by this study was conducted. We aimed to describe drug utilization, disease progression, and adverse drug events of COVID-19.\n\nA retrospective, single-center case series study enrolled 165 consecutive hospitalized COVID-19 patients who were followed up until March 25, 2020, from a designated hospital in Wuhan. Patients were grouped by a baseline degree of severity: non-severe and severe. An analytical study of drug utilization, disease progression, and adverse events (AEs) of COVID-19 was conducted.\n\nOf the 165 COVID-19 cases, antivirals, antibacterials, glucocorticoids, and traditional Chinese medicine (TCM) were administered to 92.7%, 98.8%, 68.5%, and 55.2% of patients, respectively. The total kinds of drugs administered to the severe subgroup [26, interquartile range (IQR) 18-39] were 11 more than the non-severe subgroup (15, IQR 10-24), regardless of comorbidities. The 2 most common combinations of medications in the 165 cases were 'antiviral therapy + glucocorticoids + TCM' (81, 49.1%) and 'antiviral therapy + glucocorticoids' (23, 13.9%). Compared with non-severe cases, severe cases received more glucocorticoids (88.5% vs. 66.2%, P=0.02), but less TCM (50.0% vs. 63.3%, P=0.20), and suffered a higher percentage of death (34.6% vs. 7.2%, P=0.001). At the end of the follow-up, 130 (78.8%) patients had been discharged, and 24 (14.5%) died. There were 13 patients (7.9%) who had elevated liver enzymes, and 49 patients (29.7%) presented with worsening kidney function during the follow-up.\n\nOf the 165 COVID-19 patients, the fatality rate remained high (14.5%). Drug utilization for COVID-19 was diverse and generally complied with the existing guidelines. Combination regimens containing antiviral drugs might be beneficial to assist COVID-19 recovery. Additionally, liver and kidney AEs should not be ignored.", "doi": "10.21037/atm-20-4960", "pmid": "33708933", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "atm-09-04-306"}, {"db": "pmc", "key": "PMC7944318"}], "notes": [], "created": "2021-03-17T07:19:03.452Z", "modified": "2021-04-14T04:53:53.274Z"}, {"entity": "publication", "iuid": "b7f77ec5886a47618ad2a40f1ed9e96b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b7f77ec5886a47618ad2a40f1ed9e96b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b7f77ec5886a47618ad2a40f1ed9e96b"}}, "title": "A literature survey of the robotic technologies during the COVID-19 pandemic", "authors": [{"family": "Wang", "given": "Xi Vincent", "initials": "XV"}, {"family": "Wang", "given": "Lihui", "initials": "L"}], "type": "journal-article", "published": "2021-02-00", "journal": {"title": "Journal of Manufacturing Systems", "issn": "0278-6125", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Since the late 2019, the COVID-19 pandemic has been spread all around the world. The pandemic is a critical challenge to the health and safety of the general public, the medical staff and the medical systems worldwide. It has been globally proposed to utilise robots during the pandemic, to improve the treatment of patients and leverage the load of the medical system. However, there is still a lack of detailed and systematic review of the robotic research for the pandemic, from the technologies' perspective. Thus a thorough literature survey is conducted in this research and more than 280 publications have been reviewed, with the focus on robotics during the pandemic. The main contribution of this literature survey is to answer two research questions, i.e. 1) what the main research contributions are to combat the pandemic from the robotic technologies' perspective, and 2) what the promising supporting technologies are needed during and after the pandemic to help and guide future robotics research. The current achievements of robotic technologies are reviewed and discussed in different categories, followed by the identification of the representative work's technology readiness level. The future research trends and essential technologies are then highlighted, including artificial intelligence, 5 G, big data, wireless sensor network, and human-robot collaboration.", "doi": "10.1016/j.jmsy.2021.02.005", "pmid": "33612914", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-02-22T14:09:42.828Z", "modified": "2021-03-01T10:31:09.387Z"}, {"entity": "publication", "iuid": "63a879b92bde4fafb933f2c227e84d95", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63a879b92bde4fafb933f2c227e84d95.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63a879b92bde4fafb933f2c227e84d95"}}, "title": "The screening and evaluation of potential clinically significant HIV drug combinations against the SARS-CoV-2 virus.", "authors": [{"family": "Tomi\u0107", "given": "Dra\u0161ko", "initials": "D"}, {"family": "Davidovi\u0107", "given": "Davor", "initials": "D"}, {"family": "Szasz", "given": "Attila Marcel", "initials": "AM"}, {"family": "Rezeli", "given": "Melinda", "initials": "M"}, {"family": "Pirki\u0107", "given": "Boris", "initials": "B"}, {"family": "Petrik", "given": "Jozsef", "initials": "J"}, {"family": "Vrca", "given": "Vesna Ba\u010di\u0107", "initials": "VB"}, {"family": "Jan\u0111el", "given": "Vladimir", "initials": "V"}, {"family": "Lipi\u0107", "given": "Tomislav", "initials": "T"}, {"family": "Skala", "given": "Karolj", "initials": "K"}, {"family": "Mesari\u0107", "given": "Josip", "initials": "J"}, {"family": "Peri\u0161a", "given": "Marija Milkovi\u0107", "initials": "MM"}, {"family": "\u0160ojat", "given": "Zorislav", "initials": "Z"}, {"family": "Rogina", "given": "Branka Medved", "initials": "BM"}], "type": "journal article", "published": "2021-01-30", "journal": {"title": "Inform Med Unlocked", "issn": "2352-9148", "issn-l": null, "volume": "23", "issue": null, "pages": "100529"}, "abstract": "Spike glycoprotein is essential for the reproduction of the SARS-CoV-2 virus, and its inhibition using already approved antiviral drugs may open new avenues for treatment of patients with the COVID-19 disease. Because of that we analyzed the inhibition of SARS-CoV-2 spike glycoprotein with FDA-approved antiviral drugs and their double and triple combinations. We used the Vini in silico model of cancer to perform this virtual drug screening, showing HIV drugs to be the most effective. Besides, the combination of cobicistat-abacavir-rilpivirine HIV drugs demonstrated the highest in silico efficacy of inhibiting SARS-CoV-2 spike glycoprotein. Therefore, a clinical trial of cobicistat-abacavir-rilpivirine on a limited number of COVID-19 patients in moderately severe and severe condition is warranted.", "doi": "10.1016/j.imu.2021.100529", "pmid": "33553571", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S2352-9148(21)00019-8"}, {"db": "pmc", "key": "PMC7847290"}, {"db": "URL", "key": "http://fulir.irb.hr/6161/", "description": "Results of the efficacy of FDA approved antiviral drugs on SARS-CoV-2 spike glycoprotein"}, {"db": "URL", "key": "https://github.com/draskot/Vini", "description": "The Vini in silico model of cancer"}], "notes": [], "created": "2021-02-10T18:47:44.044Z", "modified": "2021-06-21T14:53:11.203Z"}, {"entity": "publication", "iuid": "550f6ada91ba4b7184d5660c34607b68", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/550f6ada91ba4b7184d5660c34607b68.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/550f6ada91ba4b7184d5660c34607b68"}}, "title": "The Development of Swedish Military Healthcare System: Part II-Re-evaluating the Military and Civilian Healthcare Systems in Crises Through a Dialogue and Study Among Practitioners.", "authors": [{"family": "Khorram-Manesh", "given": "Amir", "initials": "A", "orcid": "0000-0002-2734-5733", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c1cf8fb45614882aa1817af7e3da375.json"}}, {"family": "Burkle", "given": "Frederick M", "initials": "FM"}, {"family": "Phattharapornjaroen", "given": "Phatthranit", "initials": "P"}, {"family": "Ahmadi Marzaleh", "given": "Milad", "initials": "M"}, {"family": "Sultan", "given": "Mohammed Al", "initials": "MA"}, {"family": "M\u00e4ntysaari", "given": "Matti", "initials": "M"}, {"family": "Carlstr\u00f6m", "given": "Eric", "initials": "E"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K", "orcid": "0000-0003-4368-6850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6bbd56fa5d243618a08005b61a9f749.json"}}, {"family": "Santamaria", "given": "Emelia", "initials": "E"}, {"family": "Comandante", "given": "John David", "initials": "JD"}, {"family": "Dobson", "given": "Robert", "initials": "R"}, {"family": "Hreckovski", "given": "Boris", "initials": "B"}, {"family": "Torgersen", "given": "Glenn-Egil", "initials": "GE"}, {"family": "Mortelmans", "given": "Luc J", "initials": "LJ"}, {"family": "de Jong", "given": "Mirjam", "initials": "M"}, {"family": "Robinson", "given": "Yohan", "initials": "Y"}], "type": "journal article", "published": "2021-01-30", "journal": {"title": "Mil Med", "issn": "1930-613X", "volume": "186", "issue": "3-4", "pages": "e442-e450", "issn-l": "0026-4075"}, "abstract": "Historical changes have transformed Sweden from being an offensive to a defensive and collaborative nation with national and international engagement, allowing it to finally achieve the ground for the civilian-military collaboration and the concept of a total defense healthcare. At the same time, with the decreasing number of international and interstate conflicts, and the military's involvement in national emergencies and humanitarian disaster relief, both the need and the role of the military healthcare system within the civilian society have been challenged. The recent impact of the COVID-19 in the USA and the necessity of military involvement have led health practitioners to anticipate and re-evaluate conditions that might exceed the civilian capacity of their own countries and the need to have collaboration with the military healthcare. This study investigated both these challenges and views from practitioners regarding the benefits of such collaboration and the manner in which it would be initiated.\n\nA primary study was conducted among responsive countries using a questionnaire created using the Nominal Group Technique. Relevant search subjects and keywords were extracted for a systematic review of the literature, according to the PRISMA model.\n\nThe 14 countries responding to the questionnaire had either a well-developed military healthcare system or units created in collaboration with the civilian healthcare. The results from the questionnaire and the literature review indicated a need for transfer of military medical knowledge and resources in emergencies to the civilian health components, which in return, facilitated training opportunities for the military staff to maintain their skills and competencies.\n\nAs the world witnesses a rapid change in the etiology of disasters and various crises, neither the military nor the civilian healthcare systems can address or manage the outcomes independently. There is an opportunity for both systems to develop future healthcare in collaboration. Rethinking education and training in war and conflict is indisputable. Collaborative educational initiatives in disaster medicine, public health and complex humanitarian emergencies, international humanitarian law, and the Geneva Convention, along with advanced training in competency-based skill sets, should be included in the undergraduate education of health professionals for the benefit of humanity.", "doi": "10.1093/milmed/usaa364", "pmid": "33135765", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7665683"}, {"db": "pii", "key": "5950402"}], "notes": [], "created": "2020-11-27T11:01:18.112Z", "modified": "2023-06-19T14:41:51.162Z"}, {"entity": "publication", "iuid": "ae2205c49d6349c8ac8f0513a453076f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ae2205c49d6349c8ac8f0513a453076f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ae2205c49d6349c8ac8f0513a453076f"}}, "title": "Resilience and mental health during the COVID-19 pandemic.", "authors": [{"family": "Verdolini", "given": "Norma", "initials": "N"}, {"family": "Amoretti", "given": "Silvia", "initials": "S"}, {"family": "Montejo", "given": "Laura", "initials": "L"}, {"family": "Garc\u00eda-Rizo", "given": "Clemente", "initials": "C"}, {"family": "Hogg", "given": "Bridget", "initials": "B"}, {"family": "Mezquida", "given": "Gisela", "initials": "G"}, {"family": "Rabelo-da-Ponte", "given": "Francisco Diego", "initials": "FD"}, {"family": "Vallespir", "given": "Catalina", "initials": "C"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Martinez-Aran", "given": "Anabel", "initials": "A"}, {"family": "Pacchiarotti", "given": "Isabella", "initials": "I"}, {"family": "Rosa", "given": "Adriane R", "initials": "AR"}, {"family": "Bernardo", "given": "Miguel", "initials": "M"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Torrent", "given": "Carla", "initials": "C"}, {"family": "Sol\u00e9", "given": "Brisa", "initials": "B"}], "type": "journal article", "published": "2021-01-29", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "volume": "283", "issue": null, "pages": "156-164", "issn-l": null}, "abstract": "Resilience is a process that allows recovery from or adaptation to adversities. The aim of this study was to evaluate state resilience during the COVID-19 pandemic in psychiatric patients (PP), unaffected relatives (UR) and community controls (CC).\n\nThis study is part of the Barcelona ResIlience Survey for Mental Health COVID-19 (BRIS-MHC) project. Logistic regression models were performed to identify mental health outcomes associated with bad state resilience and predictors of good state resilience. The association between state resilience and specific affective temperaments as well as their influence on the association between depressive symptoms and state resilience were verified.\n\nThe study recruited 898 participants that took part in the survey. The presence of depressive symptoms was a predictor of bad state resilience in PP (\u03b2=0.110, OR=1.117, p=0.028). No specific mental health outcome was associated with bad state resilience in UR and CC. Predictors of good state resilience in PP were having pursued hobbies/conducted home tasks (\u03b2=1.261, OR=3.528, p=0.044) and level of organization in the family (\u03b2=0.986, OR=2.682, p=0.008). Having a controlling family was inversely associated with good state resilience in CC (\u03b2=-1.004, OR=0.367, p=0.012). The association between bad state resilience and depressive symptoms was partially mediated by affective temperaments.\n\nParticipants self-reported their psychiatric diagnoses, their relatives' diagnoses or the absence of a psychiatric disorder, as well as their psychiatric symptoms.\n\nEnhancing resilience and coping strategies in the face of the COVID-19 pandemic might have important implications in terms of mental health outcomes.", "doi": "10.1016/j.jad.2021.01.055", "pmid": "33556749", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0165-0327(21)00072-0"}], "notes": [], "created": "2021-02-10T18:49:17.593Z", "modified": "2021-02-26T08:47:00.157Z"}, {"entity": "publication", "iuid": "44648b3c4cbd4654ac3ed76ef11c460b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44648b3c4cbd4654ac3ed76ef11c460b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44648b3c4cbd4654ac3ed76ef11c460b"}}, "title": "Epidemiological modeling in StochSS Live!", "authors": [{"family": "Jiang", "given": "Richard", "initials": "R"}, {"family": "Jacob", "given": "Bruno", "initials": "B"}, {"family": "Geiger", "given": "Matthew", "initials": "M"}, {"family": "Matthew", "given": "Sean", "initials": "S"}, {"family": "Rumsey", "given": "Bryan", "initials": "B"}, {"family": "Singh", "given": "Prashant", "initials": "P"}, {"family": "Wrede", "given": "Fredrik", "initials": "F"}, {"family": "Yi", "given": "Tau-Mu", "initials": "TM"}, {"family": "Drawert", "given": "Brian", "initials": "B"}, {"family": "Hellander", "given": "Andreas", "initials": "A"}, {"family": "Petzold", "given": "Linda", "initials": "L"}], "type": "journal article", "published": "2021-01-29", "journal": {"title": "Bioinformatics", "issn": "1367-4811", "volume": null, "issue": null, "issn-l": null}, "abstract": "We present StochSS Live!, a web-based service for modeling, simulation, and analysis of a wide range of mathematical, biological and biochemical systems. Using an epidemiological model of COVID-19, we demonstrate the power of StochSS Live! to enable researchers to quickly develop a deterministic or a discrete stochastic model, infer its parameters, and analyze the results.\n\nStochSS Live! is freely available at https://live.stochss.org/.\n\nAvailable at https://github.com/StochSS/Covid19_Modeling.", "doi": "10.1093/bioinformatics/btab061", "pmid": "33512399", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "6123781"}], "notes": [], "created": "2021-02-04T18:48:01.203Z", "modified": "2021-02-26T08:46:13.077Z"}, {"entity": "publication", "iuid": "2ff4fada5f5b4c6dbdc18860294d599a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ff4fada5f5b4c6dbdc18860294d599a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ff4fada5f5b4c6dbdc18860294d599a"}}, "title": "Clinical management of patients with genetic obesity during COVID-19 pandemic: position paper of the ESE Growth & Genetic Obesity COVID-19 Study Group and Rare Endo-ERN main thematic group on Growth and Obesity.", "authors": [{"family": "De Groot", "given": "Cornelis Jan", "initials": "CJ"}, {"family": "Poitou Bernert", "given": "Christine", "initials": "C"}, {"family": "Coupaye", "given": "Muriel", "initials": "M"}, {"family": "Clement", "given": "Karine", "initials": "K"}, {"family": "Paschou", "given": "Stavroula A", "initials": "SA"}, {"family": "Charmandari", "given": "Evangelia", "initials": "E"}, {"family": "Kanaka-Gantenbein", "given": "Christina", "initials": "C"}, {"family": "Wabitsch", "given": "Martin", "initials": "M"}, {"family": "Buddingh", "given": "Emilie P", "initials": "EP"}, {"family": "Nieuwenhuijsen", "given": "Barbara", "initials": "B"}, {"family": "Marina", "given": "Ljiljana", "initials": "L"}, {"family": "Johannsson", "given": "Gudmundur", "initials": "G"}, {"family": "Van Den Akker", "given": "E L T", "initials": "ELT"}], "type": "journal article", "published": "2021-01-29", "journal": {"title": "Endocrine", "issn": "1559-0100", "volume": null, "issue": null, "issn-l": "1355-008X"}, "abstract": "This article aims to provide guidance on prevention and treatment of COVID-19 in patients with genetic obesity. Key principals of the management of patients with genetic obesity during COVID-19 pandemic for patients that have contracted COVID-19 are to be aware of: possible adrenal insufficiency (e.g., POMC deficiency, PWS); a more severe course in patients with concomitant immunodeficiency (e.g., LEP and LEPR deficiency), although defective leptin signalling could also be protective against the pro-inflammatory phenotype of COVID-19; disease severity being masked by insufficient awareness of symptoms in syndromic obesity patients with intellectual deficit (in particular PWS); to adjust medication dose to increased body size, preferably use dosing in m2; the high risk of malnutrition in patients with Sars-Cov2 infection, even in case of obesity. Key principals of the obesity management during the pandemic are to strive for optimal obesity management and a healthy lifestyle within the possibilities of the regulations to prevent weight (re)gain and to address anxiety within consultations, since prevalence of anxiety for COVID-19 is underestimated.", "doi": "10.1007/s12020-021-02619-y", "pmid": "33512658", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s12020-021-02619-y"}], "notes": [], "created": "2021-02-01T14:17:49.638Z", "modified": "2021-02-04T18:46:35.437Z"}, {"entity": "publication", "iuid": "1dd7b99287a64aae82fbb66fa2f1ee64", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1dd7b99287a64aae82fbb66fa2f1ee64.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1dd7b99287a64aae82fbb66fa2f1ee64"}}, "title": "The angiotensin type 2 receptor agonist C21 restores respiratory function in COVID19 - a double-blind, randomized, placebo-controlled Phase 2 trial", "authors": [{"family": "Tornling", "given": "Goran", "initials": "G"}, {"family": "Batta", "given": "Rohit", "initials": "R"}, {"family": "Porter", "given": "Joanna", "initials": "J"}, {"family": "Bengtsson", "given": "Thomas", "initials": "T"}, {"family": "Parmar", "given": "Kartikeya", "initials": "K"}, {"family": "Kashiva", "given": "Reema", "initials": "R"}, {"family": "Cohrt", "given": "Anne Kartine", "initials": "AK"}, {"family": "Westergaard", "given": "Kate", "initials": "K"}, {"family": "Hallberg", "given": "Anders", "initials": "A"}, {"family": "Dalsgaard", "given": "Carl Johan", "initials": "CJ"}, {"family": "Raud", "given": "Johan", "initials": "J"}], "type": "posted-content", "published": "2021-01-28", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.01.26.21250511", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-01-29T17:30:36.012Z", "modified": "2021-04-14T04:54:19.107Z"}, {"entity": "publication", "iuid": "99f3ad7311d94bdfb953d113b4c13f07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/99f3ad7311d94bdfb953d113b4c13f07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/99f3ad7311d94bdfb953d113b4c13f07"}}, "title": "Prosociality predicts health behaviors during the COVID-19 pandemic.", "authors": [{"family": "Campos-Mercade", "given": "Pol", "initials": "P"}, {"family": "Meier", "given": "Armando N", "initials": "AN"}, {"family": "Schneider", "given": "Florian H", "initials": "FH"}, {"family": "Wengstr\u00f6m", "given": "Erik", "initials": "E"}], "type": "journal article", "published": "2021-01-28", "journal": {"title": "J Public Econ", "issn": "0047-2727", "issn-l": null, "volume": "195", "issue": null, "pages": "104367"}, "abstract": "Socially responsible behavior is crucial for slowing the spread of infectious diseases. However, economic and epidemiological models of disease transmission abstract from prosocial motivations as a driver of behaviors that impact the health of others. In an incentivized study, we show that a large majority of people are very reluctant to put others at risk for their personal benefit. Moreover, this experimental measure of prosociality predicts health behaviors during the COVID-19 pandemic, measured in a separate and ostensibly unrelated study with the same people. Prosocial individuals are more likely to follow physical distancing guidelines, stay home when sick, and buy face masks. We also find that prosociality measured two years before the pandemic predicts health behaviors during the pandemic. Our findings indicate that prosociality is a stable, long-term predictor of policy-relevant behaviors, suggesting that the impact of policies on a population may depend on the degree of prosociality.", "doi": "10.1016/j.jpubeco.2021.104367", "pmid": "33531719", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0047-2727(21)00003-7"}, {"db": "pmc", "key": "PMC7842154"}], "notes": [], "created": "2021-02-04T18:15:49.542Z", "modified": "2021-06-18T11:18:04.011Z"}, {"entity": "publication", "iuid": "6a6cc2301530439993435a8e3a9ee021", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a6cc2301530439993435a8e3a9ee021.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a6cc2301530439993435a8e3a9ee021"}}, "title": "International collaboration and covid-19: what are we doing and where are we going?", "authors": [{"family": "Bump", "given": "Jesse B", "initials": "JB"}, {"family": "Friberg", "given": "Peter", "initials": "P"}, {"family": "Harper", "given": "David R", "initials": "DR"}], "type": "journal-article", "published": "2021-01-28", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "372", "issue": null, "pages": "n180", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.n180", "pmid": "33509953", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-29T15:09:32.995Z", "modified": "2021-02-04T18:50:16.483Z"}, {"entity": "publication", "iuid": "66069e285b254e06ab7fc0f3d4e4539a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66069e285b254e06ab7fc0f3d4e4539a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66069e285b254e06ab7fc0f3d4e4539a"}}, "title": "Functional myeloid-derived suppressor cells expand in blood but not airways of COVID-19 patients and predict disease severity", "authors": [{"family": "Falck-Jones", "given": "Sara", "initials": "S"}, {"family": "Vangeti", "given": "Sindhu", "initials": "S"}, {"family": "Yu", "given": "Meng", "initials": "M"}, {"family": "Falck-Jones", "given": "Ryan", "initials": "R"}, {"family": "Cagigi", "given": "Alberto", "initials": "A"}, {"family": "Badolati", "given": "Isabella", "initials": "I"}, {"family": "Osterberg", "given": "Bjorn", "initials": "B"}, {"family": "Lautenbach", "given": "Maximilian Julius", "initials": "MJ"}, {"family": "Ahlberg", "given": "Eric", "initials": "E"}, {"family": "Lin", "given": "Ang", "initials": "A"}, {"family": "Szurgot", "given": "Inga", "initials": "I"}, {"family": "Lenart", "given": "Klara", "initials": "K"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Salde", "given": "Jorgen", "initials": "J"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "Lore", "given": "Karin", "initials": "K"}, {"family": "Farnert", "given": "Anna", "initials": "A"}, {"family": "Smed-Sorensen", "given": "Anna", "initials": "A"}], "type": "posted-content", "published": "2021-01-28", "journal": {"title": "J Clin Invest", "issn": "1558-8238", "issn-l": null, "volume": "131", "issue": "6", "pages": null}, "abstract": "The immunopathology of COVID-19 remains enigmatic, exhibiting immunodysregulation and T cell lymphopenia. Monocytic myeloid-derived suppressor cells (M-MDSC) are T cell suppressors that expand in inflammatory conditions, but their role in acute respiratory infections remains unclear. We studied blood and airways of COVID-19 patients across disease severity at multiple timepoints. M-MDSC frequencies were elevated in blood but not in nasopharyngeal or endotracheal aspirates of COVID-19 patients compared to controls. M-MDSCs isolated from COVID-19 patients suppressed T cell proliferation and IFN\u03b3 production partly via an arginase-1 (Arg-1) dependent mechanism. Furthermore, patients showed increased Arg-1 and IL-6 plasma levels. COVID-19 patients had fewer T cells, and displayed downregulated expression of the CD3\u03b6 chain. Ordinal regression showed that early M-MDSC frequency predicted subsequent disease severity. In conclusion, M-MDSCs expand in blood of COVID-19 patients, suppress T cells and strongly associate with disease severity, suggesting a role for M-MDSCs in the dysregulated COVID-19 immune response.", "doi": "10.1172/JCI144734", "pmid": "33492309", "labels": {"Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Research Area: High-throughput and high-content serology": null, "Type: Journal article": null, "Category: Health": null, "Category: Proteins": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-10-30T11:28:02.561Z", "modified": "2021-06-11T14:27:07.830Z"}, {"entity": "publication", "iuid": "ea8fff00c253452595ddbecf13dfa262", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ea8fff00c253452595ddbecf13dfa262.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ea8fff00c253452595ddbecf13dfa262"}}, "title": "Covid-19\u2014a rehearsal to build a greener and healthier society", "authors": [{"family": "Nilsson", "given": "Maria", "initials": "M"}, {"family": "Ebi", "given": "Kristie L", "initials": "KL"}, {"family": "Campbell-Lendrum", "given": "Diarmid", "initials": "D"}, {"family": "Kone", "given": "Brama", "initials": "B"}, {"family": "Friberg", "given": "Peter", "initials": "P"}], "type": "journal-article", "published": "2021-01-28", "journal": {"title": "BMJ", "issn": "1756-1833", "issn-l": null, "volume": "372", "issue": null, "pages": "n127"}, "abstract": null, "doi": "10.1136/bmj.n127", "pmid": "33509800", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-01-29T15:10:48.019Z", "modified": "2022-11-23T09:03:00.846Z"}, {"entity": "publication", "iuid": "239215138eaa431c808a711ca70c705f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/239215138eaa431c808a711ca70c705f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/239215138eaa431c808a711ca70c705f"}}, "title": "Collaborative platform trials to fight COVID-19: methodological and regulatory considerations for a better societal outcome.", "authors": [{"family": "Collignon", "given": "Olivier", "initials": "O"}, {"family": "Burman", "given": "Carl-Fredrik", "initials": "C"}, {"family": "Posch", "given": "Martin", "initials": "M"}, {"family": "Schiel", "given": "Anja", "initials": "A"}], "type": "journal article", "published": "2021-01-28", "journal": {"title": "Clin Pharmacol Ther", "issn": "1532-6535", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "For the development of COVID-19 drugs during the ongoing pandemic, speed is of essence while quality of evidence is of paramount importance. While thousands of COVID-19 trials were rapidly started, many are unlikely to provide robust statistical evidence and meet regulatory standards, e.g. because of lack of randomisation or insufficient power. This has led to an inefficient use of time and resources. With more coordination, the sheer number of patients in these trials might have generated convincing data for several investigational treatments. Collaborative platform trials, comparing several drugs to a shared control arm, are an attractive solution. Those trials can utilise a variety of adaptive design features in order to accelerate the finding of life-saving treatments. In this manuscript we discuss several possible designs, illustrate them via simulations and also discuss challenges, such as the heterogeneity of the target population, time-varying standard of care, and the potentially high number of false hypothesis rejections in Phase 2 and Phase 3. We provide corresponding regulatory perspectives on approval and reimbursement, and note that the optimal design of a platform trial will differ with our societal objective and by stakeholder. Hasty approvals may delay the development of better alternatives, while searching relentlessly for the single most efficacious treatment may indirectly diminish the number of lives saved as time is lost. We point out the need for incentivising developers to participate in collaborative evidence-generation initiatives when a positive return on investment is not met.", "doi": "10.1002/cpt.2183", "pmid": "33506495", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-01-29T15:13:01.950Z", "modified": "2021-02-04T19:05:39.855Z"}, {"entity": "publication", "iuid": "8f4a1e192b2b45d2b8217e2dfc0de36e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f4a1e192b2b45d2b8217e2dfc0de36e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f4a1e192b2b45d2b8217e2dfc0de36e"}}, "title": "To stress or not to stress: Brain-behavior-immune interaction may weaken or promote the immune response to SARS-CoV-2.", "authors": [{"family": "Peters", "given": "Eva M J", "initials": "EMJ"}, {"family": "Schedlowski", "given": "Manfred", "initials": "M"}, {"family": "Watzl", "given": "Carsten", "initials": "C"}, {"family": "Gimsa", "given": "Ulrike", "initials": "U"}], "type": "journal article", "published": "2021-01-27", "journal": {"title": "Neurobiol Stress", "issn": "2352-2895", "issn-l": null, "volume": "14", "issue": null, "pages": "100296"}, "abstract": "The COVID-19 pandemic continues to strongly affect people with health disadvantages, creating a heavy burden on medical systems and societies worldwide. Research is growing rapidly and recently revealed that stress-related factors such as socio-economic status, may also play a pivotal role. However, stress research investigating the underlying psychoneuroimmune interactions is missing. Here we address the question whether stress-associated neuroendocrine-immune mechanisms can possibly contribute to an increase in SARS-CoV-2 infections and influence the course of COVID-19 disease. Additionally, we discuss that not all forms of stress (e.g. acute versus chronic) are detrimental and that some types of stress could attenuate infection-risk and -progression. The overall aim of this review is to motivate future research efforts to clarify whether psychosocial interventions have the potential to optimize neuroendocrine-immune responses against respiratory viral infections during and beyond the COVID-19 pandemic. The current state of research on different types of stress is summarized in a comprehensive narrative review to promote a psychoneuroimmune understanding of how stress and its mediators cortisol, (nor)adrenaline, neuropeptides and neurotrophins can shape the immune defense against viral diseases. Based on this understanding, we describe how people with high psychosocial stress can be identified, which behaviors and psychosocial interventions may contribute to optimal stress management, and how psychoneuroimmune knowledge can be used to improve adequate care for COVID-19 and other patients with viral infections.", "doi": "10.1016/j.ynstr.2021.100296", "pmid": "33527083", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2352-2895(21)00004-7"}, {"db": "pmc", "key": "PMC7839386"}], "notes": [], "created": "2021-02-04T18:18:58.208Z", "modified": "2021-06-18T11:16:45.923Z"}, {"entity": "publication", "iuid": "a07ce6c124df46ce8d299b82d7921c13", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a07ce6c124df46ce8d299b82d7921c13.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a07ce6c124df46ce8d299b82d7921c13"}}, "title": "Mental Health Consequences for Healthcare Workers During the COVID-19 Pandemic: A Scoping Review to Draw Lessons for LMICs.", "authors": [{"family": "Moitra", "given": "Modhurima", "initials": "M"}, {"family": "Rahman", "given": "Muhammad", "initials": "M"}, {"family": "Collins", "given": "Pamela Y", "initials": "PY"}, {"family": "Gohar", "given": "Fatima", "initials": "F"}, {"family": "Weaver", "given": "Marcia", "initials": "M"}, {"family": "Kinuthia", "given": "John", "initials": "J"}, {"family": "R\u00f6ssler", "given": "Wulf", "initials": "W"}, {"family": "Petersen", "given": "Stefan", "initials": "S"}, {"family": "Unutzer", "given": "Jurgen", "initials": "J"}, {"family": "Saxena", "given": "Shekhar", "initials": "S"}, {"family": "Huang", "given": "Keng Yen", "initials": "KY"}, {"family": "Lai", "given": "Joanna", "initials": "J"}, {"family": "Kumar", "given": "Manasi", "initials": "M"}], "type": "journal article", "published": "2021-01-27", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "issue": null, "pages": "602614", "issn-l": "1664-0640"}, "abstract": "Background: The COVID-19 pandemic has had a significant impact on the mental health of healthcare workers (HCWs) particularly in low and middle-income countries (LMICs). This scoping review provides a summary of current evidence on the mental health consequences of COVID on HCWs. Methods: A scoping review was conducted searching PubMed and Embase for articles relevant to mental health conditions among HCWs during COVID-19. Relevant articles were screened and extracted to summarize key outcomes and findings. Results: A total of fifty-one studies were included in this review. Depressive symptoms, anxiety symptoms, psychological trauma, insomnia and sleep quality, workplace burnout and fatigue, and distress were the main outcomes reviewed. Most studies found a high number of symptoms endorsed for depression, anxiety, and other conditions. We found differences in symptoms by sex, age, and HCW role, with female, younger-aged, frontline workers, and non-physician workers being affected more than other subgroups. Conclusion: This review highlights the existing burden of mental health conditions reported by HCWs during COVID-19. It also demonstrates emerging disparities among affected HCW subgroups. This scoping review emphasizes the importance of generating high quality evidence and developing informed interventions for HCW mental health with a focus on LMICs.", "doi": "10.3389/fpsyt.2021.602614", "pmid": "33584383", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7873361"}], "notes": [], "created": "2021-02-17T14:47:10.441Z", "modified": "2021-02-26T08:47:00.126Z"}, {"entity": "publication", "iuid": "5639168d872f41ad8a36f99059c0cd8a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5639168d872f41ad8a36f99059c0cd8a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5639168d872f41ad8a36f99059c0cd8a"}}, "title": "Lung Ultrasound for Identification of Patients Requiring Invasive Mechanical Ventilation in COVID-19.", "authors": [{"family": "Seiler", "given": "Claudia", "initials": "C"}, {"family": "Klingberg", "given": "Cecilia", "initials": "C"}, {"family": "H\u00e5rdstedt", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-01-26", "journal": {"title": "J Ultrasound Med", "issn": "1550-9613", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Indication for invasive mechanical ventilation in COVID-19 pneumonia has been a major challenge. This study aimed to evaluate if lung ultrasound (LUS) can assist identification of requirement of invasive mechanical ventilation in moderate to severe COVID-19 pneumonia.\r\n\r\nBetween April 23 and November 12, 2020, hospitalized patients with moderate to severe COVID-19 (oxygen demand \u22654 L/min) were included consecutively. Lung ultrasound was performed daily until invasive mechanical ventilation (IMV-group) or spontaneous recovery (non-IMV-group). Clinical parameters and lung ultrasound findings were compared between groups, at intubation (IMV-group) and highest oxygen demand (non-IMV-group). A reference group with oxygen demand <4 L/min was examined at hospital admission.\r\n\r\nAltogether 72 patients were included: 50 study patients (IMV-group, n = 23; non-IMV-group, n = 27) and 22 reference patients. LUS-score correlated to oxygen demand (SpO 2 /FiO2 -ratio) (r = 0.728; p < 0.0001) and was higher in the IMV-group compared to the non-IMV-group (20.0 versus 18.0; p = 0.026). Based on receiver operating characteristic analysis, a LUS-score of 19.5 was identified as cut-off for requirement of invasive mechanical ventilation (area under the curve 0.68; sensitivity 56%, specificity 74%). In 6 patients, LUS identified critical coexisting conditions. Respiratory rate and oxygenation index ((SpO2 /FiO2 )/respiratory rate) \u22654.88 identified no requirement of invasive mechanical ventilation with a positive predictive value of 87% and negative predictive value of 100%.\r\n\r\nLUS-score had only a moderate diagnostic value for requirement of invasive mechanical ventilation in moderate to severe COVID-19. However, LUS proved valuable as complement to respiratory parameters in guidance of disease severity and identifying critical coexisting conditions.", "doi": "10.1002/jum.15617", "pmid": "33496362", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-29T15:37:32.985Z", "modified": "2021-06-18T11:03:00.455Z"}, {"entity": "publication", "iuid": "8a7a467b9af54956b811e2c8c056c6fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a7a467b9af54956b811e2c8c056c6fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a7a467b9af54956b811e2c8c056c6fd"}}, "title": "Community Participation Approaches for Effective National COVID-19 Pandemic Preparedness and Response: An Experience From Oman.", "authors": [{"family": "Al Siyabi", "given": "Huda", "initials": "H"}, {"family": "Al Mukhaini", "given": "Said", "initials": "S"}, {"family": "Kanaan", "given": "Mohsen", "initials": "M"}, {"family": "Al Hatmi", "given": "Sumaya", "initials": "S"}, {"family": "Al Anqoudi", "given": "Zahir", "initials": "Z"}, {"family": "Al Kalbani", "given": "Ahmed", "initials": "A"}, {"family": "Al Bahri", "given": "Zakiya", "initials": "Z"}, {"family": "Wannous", "given": "Chadia", "initials": "C"}, {"family": "Al Awaidy", "given": "Salah T", "initials": "ST"}], "type": "journal article", "published": "2021-01-26", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "616763", "issn-l": "2296-2565"}, "abstract": "Oman, like other countries in the world, was affected by the COVID-19 pandemic. Since the WHO's declaration of the pandemic, the Ministry of Health of Oman has initiated its preparedness and response to the pandemic, with community participation as one of the key components of the national preparedness and response plan. This paper is a descriptive study aims at describing the three community approaches that exist in Oman and reviewing their role in preparedness and response strategies to COVID-19 pandemic and discuss the lessons learned. Community participation approaches in Oman were translated into action during the pandemic through empowering community members, mobilizing resources, and strengthening the ownership among the local community to ensure effective advocacy, proper networking, and dissemination of information and, subsequently, actions at the level of the community. The first community participation approach is community organizations within the healthy cities and villages initiative, which facilitated networking and acted as a platform for community engagement, reviewing the health information and updating them accordingly to meet evloving demands. The second approach is Willayat (District) health committees, with their unique multi-sectoral structure, that enhanced collaboration at the state level with different community leaders and groups to develop pandemic action plans, which were implemented using available local resources. The third approach is community volunteers that remain the key information providers, particularly when physical access becomes limited due to physical distancing measures. Based on this review, we advocate to further strengthen these approaches and recommends that they are implemented for the protection and promotion of health and well-being, including for health emergencies.", "doi": "10.3389/fpubh.2020.616763", "pmid": "33575243", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7870984"}], "notes": [], "created": "2021-02-15T12:53:28.419Z", "modified": "2021-02-26T08:47:00.041Z"}, {"entity": "publication", "iuid": "a3ae0299260c4571aa064bee1cca91e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3ae0299260c4571aa064bee1cca91e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3ae0299260c4571aa064bee1cca91e8"}}, "title": "Anthropogenic Infection of Cats during the 2020 COVID-19 Pandemic.", "authors": [{"family": "Hosie", "given": "Margaret J", "initials": "MJ", "orcid": "0000-0002-4313-5023", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f40c8d7a2904c3b8fde7546efa3935f.json"}}, {"family": "Hofmann-Lehmann", "given": "Regina", "initials": "R", "orcid": "0000-0001-9750-4296", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5e8b0620f9b4c208af59a06749465c2.json"}}, {"family": "Hartmann", "given": "Katrin", "initials": "K"}, {"family": "Egberink", "given": "Herman", "initials": "H", "orcid": "0000-0001-6852-5936", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab5a969ee05c459cad512e7da7eb80b2.json"}}, {"family": "Truyen", "given": "Uwe", "initials": "U"}, {"family": "Addie", "given": "Diane D", "initials": "DD", "orcid": "0000-0001-7843-2661", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7c3e3dfc64a47758df348a154925228.json"}}, {"family": "Bel\u00e1k", "given": "S\u00e1ndor", "initials": "S"}, {"family": "Boucraut-Baralon", "given": "Corine", "initials": "C", "orcid": "0000-0002-6033-450X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/55399dde51584fb2ac0878ca1581a6c1.json"}}, {"family": "Frymus", "given": "Tadeusz", "initials": "T", "orcid": "0000-0002-9160-1455", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aee4488d842149ff9fec4d44f5bf4e21.json"}}, {"family": "Lloret", "given": "Albert", "initials": "A"}, {"family": "Lutz", "given": "Hans", "initials": "H"}, {"family": "Marsilio", "given": "Fulvio", "initials": "F", "orcid": "0000-0001-9552-1199", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc7ae4bb1210413589a00714602bed79.json"}}, {"family": "Pennisi", "given": "Maria Grazia", "initials": "MG"}, {"family": "Tasker", "given": "S\u00e9verine", "initials": "S", "orcid": "0000-0002-4059-1402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25cba4cd2417458e9d74ff2ba1d10f5b.json"}}, {"family": "Thiry", "given": "Etienne", "initials": "E"}, {"family": "M\u00f6stl", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2021-01-26", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "2", "issn-l": "1999-4915"}, "abstract": "COVID-19 is a severe acute respiratory syndrome (SARS) caused by a new coronavirus (CoV), SARS-CoV-2, which is closely related to SARS-CoV that jumped the animal-human species barrier and caused a disease outbreak in 2003. SARS-CoV-2 is a betacoronavirus that was first described in 2019, unrelated to the commonly occurring feline coronavirus (FCoV) that is an alphacoronavirus associated with feline infectious peritonitis (FIP). SARS-CoV-2 is highly contagious and has spread globally within a few months, resulting in the current pandemic. Felids have been shown to be susceptible to SARS-CoV-2 infection. Particularly in the Western world, many people live in very close contact with their pet cats, and natural infections of cats in COVID-19-positive households have been described in several countries. In this review, the European Advisory Board on Cat Diseases (ABCD), a scientifically independent board of experts in feline medicine from 11 European Countries, discusses the current status of SARS-CoV infections in cats. The review examines the host range of SARS-CoV-2 and human-to-animal transmissions, including infections in domestic and non-domestic felids, as well as mink-to-human/-cat transmission. It summarises current data on SARS-CoV-2 prevalence in domestic cats and the results of experimental infections of cats and provides expert opinions on the clinical relevance and prevention of SARS-CoV-2 infection in cats.", "doi": "10.3390/v13020185", "pmid": "33530620", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7911697"}, {"db": "pii", "key": "v13020185"}], "notes": [], "created": "2021-02-04T18:19:42.314Z", "modified": "2023-01-13T13:36:31.494Z"}, {"entity": "publication", "iuid": "30c58c30456d4cd5ba9b9340b1837eba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/30c58c30456d4cd5ba9b9340b1837eba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/30c58c30456d4cd5ba9b9340b1837eba"}}, "title": "Severe acute kidney injury associated with progression of chronic kidney disease after critical COVID-19.", "authors": [{"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Wallin", "given": "Ewa", "initials": "E"}, {"family": "Larsson", "given": "Ing-Marie", "initials": "I"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2021-01-25", "journal": {"title": "Crit Care", "issn": "1466-609X", "issn-l": "1364-8535", "volume": "25", "issue": "1", "pages": "37"}, "abstract": null, "doi": "10.1186/s13054-021-03461-4", "pmid": "33494766", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-021-03461-4"}, {"db": "ClinicalTrials.gov", "key": "NCT04474249", "description": null}], "notes": [], "created": "2021-01-28T06:54:06.133Z", "modified": "2021-06-14T14:34:29.920Z"}, {"entity": "publication", "iuid": "46ccb5a0c1e04a72b1005a9538a1ab25", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46ccb5a0c1e04a72b1005a9538a1ab25.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46ccb5a0c1e04a72b1005a9538a1ab25"}}, "title": "Elucidating the Interactions Between Heparin/Heparan Sulfate and SARS-CoV-2-Related Proteins-An Important Strategy for Developing Novel Therapeutics for the COVID-19 Pandemic.", "authors": [{"family": "Yu", "given": "Mingjia", "initials": "M"}, {"family": "Zhang", "given": "Tianji", "initials": "T"}, {"family": "Zhang", "given": "Wei", "initials": "W"}, {"family": "Sun", "given": "Qianyun", "initials": "Q"}, {"family": "Li", "given": "Hongmei", "initials": "H"}, {"family": "Li", "given": "Jin-Ping", "initials": "JP"}], "type": "journal article", "published": "2021-01-25", "journal": {"title": "Front. Mol. Biosci.", "issn": "2296-889X", "volume": "7", "issue": null, "pages": "628551", "issn-l": null}, "abstract": "Owing to the high mortality and the spread rate, the infectious disease caused by SARS-CoV-2 has become a major threat to public health and social economy, leading to over 70 million infections and 1. 6 million deaths to date. Since there are currently no effective therapeutic or widely available vaccines, it is of urgent need to look for new strategies for the treatment of SARS-CoV-2 infection diseases. Binding of a viral protein onto cell surface heparan sulfate (HS) is generally the first step in a cascade of interaction that is required for viral entry and the initiation of infection. Meanwhile, interactions of selectins and cytokines (e.g., IL-6 and TNF-\u03b1) with HS expressed on endothelial cells are crucial in controlling the recruitment of immune cells during inflammation. Thus, structurally defined heparin/HS and their mimetics might serve as potential drugs by competing with cell surface HS for the prevention of viral adhesion and modulation of inflammatory reaction. In this review, we will elaborate coronavirus invasion mechanisms and summarize the latest advances in HS-protein interactions, especially proteins relevant to the process of coronavirus infection and subsequent inflammation. Experimental and computational techniques involved will be emphasized.", "doi": "10.3389/fmolb.2020.628551", "pmid": "33569392", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7868326"}], "notes": [], "created": "2021-02-11T15:22:24.203Z", "modified": "2021-07-14T07:52:18.779Z"}, {"entity": "publication", "iuid": "c2ecaa70043f4c2dba8b717f582fc41d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2ecaa70043f4c2dba8b717f582fc41d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2ecaa70043f4c2dba8b717f582fc41d"}}, "title": "Bispecific antibody neutralizes circulating SARS-CoV-2 variants, prevents escape and protects mice from disease", "authors": [{"family": "De Gasparo", "given": "Raoul", "initials": "R"}, {"family": "Pedotti", "given": "Mattia", "initials": "M"}, {"family": "Simonelli", "given": "Luca", "initials": "L"}, {"family": "Nickl", "given": "Petr", "initials": "P"}, {"family": "Muecksch", "given": "Frauke", "initials": "F"}, {"family": "Cassaniti", "given": "Irene", "initials": "I"}, {"family": "Percivalle", "given": "Elena", "initials": "E"}, {"family": "Lorenzi", "given": "Julio C C", "initials": "JCC"}, {"family": "Mazzola", "given": "Federica", "initials": "F"}, {"family": "Magr\u00ec", "given": "Davide", "initials": "D"}, {"family": "Michalcikova", "given": "Tereza", "initials": "T"}, {"family": "Haviernik", "given": "Jan", "initials": "J"}, {"family": "Honig", "given": "Vaclav", "initials": "V"}, {"family": "Mrazkova", "given": "Blanka", "initials": "B"}, {"family": "Polakova", "given": "Natalie", "initials": "N"}, {"family": "Fortova", "given": "Andrea", "initials": "A"}, {"family": "Tureckova", "given": "Jolana", "initials": "J"}, {"family": "Iatsiuk", "given": "Veronika", "initials": "V"}, {"family": "Girolamo", "given": "Salvatore Di", "initials": "SD"}, {"family": "Palus", "given": "Martin", "initials": "M"}, {"family": "Zudova", "given": "Dagmar", "initials": "D"}, {"family": "Bednar", "given": "Petr", "initials": "P"}, {"family": "Bukova", "given": "Ivana", "initials": "I"}, {"family": "Bianchini", "given": "Filippo", "initials": "F"}, {"family": "Mehn", "given": "Dora", "initials": "D"}, {"family": "Nencka", "given": "Radim", "initials": "R"}, {"family": "Strakova", "given": "Petra", "initials": "P"}, {"family": "Pavlis", "given": "Oto", "initials": "O"}, {"family": "Rozman", "given": "Jan", "initials": "J"}, {"family": "Gioria", "given": "Sabrina", "initials": "S"}, {"family": "Camilla Sammartino", "given": "Jos\u00e8", "initials": "J"}, {"family": "Giardina", "given": "Federica", "initials": "F"}, {"family": "Gaiarsa", "given": "Stefano", "initials": "S"}, {"family": "Hammarstr\u00f6m", "given": "Qiang Pan", "initials": "QP"}, {"family": "Barnes", "given": "Christopher O", "initials": "CO"}, {"family": "Bjorkman", "given": "Pamela J", "initials": "PJ"}, {"family": "Calzolai", "given": "Luigi", "initials": "L"}, {"family": "Piralla", "given": "Antonio", "initials": "A"}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Nussenzweig", "given": "Michel C", "initials": "MC"}, {"family": "Bieniasz", "given": "Paul D", "initials": "PD"}, {"family": "Hatziioannou", "given": "Theodora", "initials": "T"}, {"family": "Prochazka", "given": "Jan", "initials": "J"}, {"family": "Sedlacek", "given": "Radislav", "initials": "R"}, {"family": "Robbiani", "given": "Davide F", "initials": "DF"}, {"family": "Ruzek", "given": "Daniel", "initials": "D"}, {"family": "Varani", "given": "Luca", "initials": "L"}], "type": "posted-content", "published": "2021-01-22", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.01.22.427567", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Proteins": null}, "xrefs": [], "notes": [], "created": "2021-06-10T03:58:04.158Z", "modified": "2021-06-10T03:58:32.998Z"}, {"entity": "publication", "iuid": "1becbf8709b94abc8098d4683f2bc703", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1becbf8709b94abc8098d4683f2bc703.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1becbf8709b94abc8098d4683f2bc703"}}, "title": "Pride and Uncertainty: A Qualitative Study of Danish Nursing Staff in Temporary COVID-19 Wards.", "authors": [{"family": "Marsaa", "given": "Kristoffer", "initials": "K"}, {"family": "Mendahl", "given": "Janni", "initials": "J"}, {"family": "Heilman", "given": "Henriette", "initials": "H"}, {"family": "Johansson", "given": "H\u00e9l\u00e8ne", "initials": "H"}, {"family": "Husum", "given": "Mette", "initials": "M"}, {"family": "Lippert", "given": "Dorthe", "initials": "D"}, {"family": "Sandholm", "given": "Niels", "initials": "N"}, {"family": "Konradsen", "given": "Hanne", "initials": "H"}], "type": "journal article", "published": "2021-01-21", "journal": {"title": "J Hosp Palliat Nurs", "issn": "1539-0705", "volume": "Publish Ahead of Print", "issue": null, "issn-l": null}, "abstract": "There is limited knowledge about the psychosocial stress among the nursing staff working on the COVID-19 wards. This article reports on the experiences of frontline health care workers as it was described to supervisors counseling the nursing staff engaged in the response to the outbreak of COVID-19. Frontline health care workers, nurses, and nurses' aides experienced major work changes. Some were transferred to the newly formed COVID-19 wards in a large Danish hospital, were given new tasks, and had to collaborate with new colleagues, while treating a new deadly and contagious disease. This study aimed to describe the reflections and experiences of the nursing staff attending supervision sessions. The palliative unit offered supervision from April 2020. A total of 9 supervision sessions were held as part of this study, and 57 nursing staff members participated in the sessions. The supervision was available to employees until the first COVID wave subsided in June 2020. During each session, supervisors took field notes and wrote field memos. The topics raised by the nursing staff during the supervision sessions ranged between pride and uncertainty. Nursing staff in COVID-19 wards were at risk of feeling an increasing burden, and there was a need for ongoing managerial attention as well as continuous visible presence and support.", "doi": "10.1097/NJH.0000000000000722", "pmid": "33496527", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "00129191-900000000-99827"}], "notes": [], "created": "2021-01-29T15:27:44.122Z", "modified": "2021-02-26T08:46:59.850Z"}, {"entity": "publication", "iuid": "6f88214beb5042b4a692919478f76efe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f88214beb5042b4a692919478f76efe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f88214beb5042b4a692919478f76efe"}}, "title": "Detection of SARS-CoV-2 using non-commercial RT-LAMP regents and raw samples.", "authors": [{"family": "Alekseenko", "given": "Alisa", "initials": "A"}, {"family": "Barrett", "given": "Donal", "initials": "D"}, {"family": "Pareja-Sanchez", "given": "Yerma", "initials": "Y"}, {"family": "Howard", "given": "Rebecca", "initials": "R"}, {"family": "Strandback", "given": "Emilia", "initials": "E"}, {"family": "Ampah-Korsah", "given": "Henry", "initials": "H"}, {"family": "Rov\u0161nik", "given": "Ur\u0161ka", "initials": "U"}, {"family": "Zuniga-Veliz", "given": "Silvia", "initials": "S"}, {"family": "Klenov", "given": "Alexander", "initials": "A"}, {"family": "Malloo", "given": "Jayshna", "initials": "J"}, {"family": "Ye", "given": "Shenglong", "initials": "S"}, {"family": "Liu", "given": "Xiyang", "initials": "X"}, {"family": "Reinius", "given": "B\u00f6jrn", "initials": "B"}, {"family": "Els\u00e4sser", "given": "Simon", "initials": "S"}, {"family": "Nyman", "given": "Tomas", "initials": "T"}, {"family": "Sandh", "given": "Gustaf", "initials": "G"}, {"family": "Yin", "given": "Xiushan", "initials": "X"}, {"family": "Pelechano", "given": "Vicent", "initials": "V"}], "type": "posted-content", "published": "2021-01-21", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "1820"}, "abstract": "RT-LAMP detection of SARS-CoV-2 has been shown as a valuable approach to scale up COVID-19 diagnostics and thus contribute to limiting the spread of the disease. Here we present the optimization of highly cost-effective in-house produced enzymes, and we benchmark their performance against commercial alternatives. We explore the compatibility between multiple DNA polymerases with high strand-displacement activity and thermostable reverse transcriptases required for RT-LAMP. We optimize reaction conditions and demonstrate their applicability using both synthetic RNA and clinical patient samples. Finally, we validated the optimized RT-LAMP assay for the detection of SARS-CoV-2 in raw nasopharyngeal samples from 184 patients. We anticipate that optimized and affordable reagents for RT-LAMP will facilitate the expansion of SARS-CoV-2 testing globally, especially in sites and settings with limited economic resources.", "doi": "10.1038/s41598-020-80352-8", "pmid": "33469065", "labels": {"Research Area: Diagnostics for virus": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Viral sequence evolution": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "URL", "key": "https://static-content.springer.com/esm/art%3A10.1038%2Fs41598-020-80352-8/MediaObjects/41598_2020_80352_MOESM3_ESM.xlsx", "description": "Numeric raw data for the amplifcation curves"}, {"db": "URL", "key": "https://static-content.springer.com/esm/art%3A10.1038%2Fs41598-020-80352-8/MediaObjects/41598_2020_80352_MOESM2_ESM.xlsx", "description": "Ct values for clinical samples from GeneXpert and all the RT-LAMP trials"}], "notes": [], "created": "2020-11-11T06:52:33.154Z", "modified": "2021-06-14T14:34:14.486Z"}, {"entity": "publication", "iuid": "91395e0a12e940bf8b5195ae8a6bcf76", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/91395e0a12e940bf8b5195ae8a6bcf76.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/91395e0a12e940bf8b5195ae8a6bcf76"}}, "title": "Should neurosurgeons continue to work in the absence of personal protective equipment during the COVID-19 era?", "authors": [{"family": "Eijkholt", "given": "Marleen", "initials": "M"}, {"family": "Hulsbergen", "given": "Alexander", "initials": "A"}, {"family": "Muskens", "given": "Ivo", "initials": "I"}, {"family": "Mathiesen", "given": "Tiit Illimar", "initials": "TI"}, {"family": "Bolger", "given": "Ciaran", "initials": "C"}, {"family": "Feldman", "given": "Zeev", "initials": "Z"}, {"family": "Kitchen", "given": "Neil", "initials": "N"}, {"family": "Sampr\u00f3n", "given": "Nicol\u00e1s", "initials": "N"}, {"family": "Sandvik", "given": "Ulrika", "initials": "U"}, {"family": "Tisell", "given": "Magnus", "initials": "M"}, {"family": "Broekman", "given": "Marike", "initials": "M"}], "type": "journal article", "published": "2021-01-20", "journal": {"title": "Acta Neurochir (Wien)", "issn": "0942-0940", "volume": null, "issue": null, "issn-l": "0001-6268"}, "abstract": "The COVID-19 pandemic has resulted in a widespread shortage of personal protective equipment (PPE). Many healthcare workers, including neurosurgeons, have expressed concern about how to safely and adequately perform their medical responsibilities in these challenging circumstances. One of these concerns revolves around the pressing question: should providers continue to work in the absence of adequate PPE? Although the first peak of the COVID-19 crisis seems to have subsided and supply of PPE has increased, concerns about insufficient PPE availability remain. Inconsistent supply, limited efficacy, and continued high demand for PPE, combined with the continued threat of a second COVID-19 wave, mean that the issues surrounding PPE availability remain unresolved, including a duty to work. This paper offers an ethical investigation of whether neurosurgeons should perform their professional responsibilities with limited availability of PPE. We evaluate ethical considerations and conflicting duties and thereby hope to facilitate providers in making a well-considered personal and moral decision about this challenging issue.", "doi": "10.1007/s00701-021-04703-8", "pmid": "33469692", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00701-021-04703-8"}], "notes": [], "created": "2021-01-22T09:12:54.748Z", "modified": "2021-01-22T09:12:54.812Z"}, {"entity": "publication", "iuid": "ac9d5631d7314b86854499c85db583c3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac9d5631d7314b86854499c85db583c3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac9d5631d7314b86854499c85db583c3"}}, "title": "Psychometric Properties of the Norwegian Version of the Fear of COVID-19 Scale.", "authors": [{"family": "Iversen", "given": "M M", "initials": "MM"}, {"family": "Norekv\u00e5l", "given": "T M", "initials": "TM"}, {"family": "Oterhals", "given": "K", "initials": "K"}, {"family": "Fadnes", "given": "L T", "initials": "LT"}, {"family": "M\u00e6land", "given": "S", "initials": "S"}, {"family": "Pakpour", "given": "A H", "initials": "AH"}, {"family": "Breivik", "given": "K", "initials": "K"}], "type": "journal article", "published": "2021-01-20", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "issn-l": null, "volume": null, "issue": null, "pages": "1-19"}, "abstract": "To examine the psychometric properties of the Norwegian version of the Fear of COVID-19 Scale (FCV-19S), randomly selected individuals from a larger registry study were invited. We assessed the reliability and validity of the instrument in a sample of 1089 adults in Norway (response rate 73%). Internal consistency measured by Cronbach's alpha (0.88) was acceptable. Omega alphaHierarchical ( \u03c9t = 0.69) was lower indicating that the general factor is less reliable, explaining 69% of the total variance. Confirmatory factor analysis indicated that the FCV-19S is not strictly unidimensional. Exploratory graph analysis and confirmatory factor analysis supported a two-factor model (cognitive and somatic fear), which were highly correlated (r = 0.84). The Norwegian version of the FCV-19S showed an underlying two-factor structure. However, the high correlation means the two latent factors (cognitive and somatic fear) act as indicators for a second-order general factor and support use of the FCV-19S sum score. The FCV-19S appears to be a valid instrument to assess fear of COVID-19 with good psychometric properties.\r\n\r\nThe online version contains supplementary material available at 10.1007/s11469-020-00454-2.", "doi": "10.1007/s11469-020-00454-2", "pmid": "33495690", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "454"}, {"db": "pmc", "key": "PMC7816751"}], "notes": [], "created": "2021-01-29T15:26:14.525Z", "modified": "2021-06-18T11:11:42.948Z"}, {"entity": "publication", "iuid": "7e73071b4d804ba5bc0bf4d6733322a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e73071b4d804ba5bc0bf4d6733322a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e73071b4d804ba5bc0bf4d6733322a1"}}, "title": "Six-Month Survival After Extracorporeal Membrane Oxygenation for Severe COVID-19.", "authors": [{"family": "Biancari", "given": "Fausto", "initials": "F"}, {"family": "Mariscalco", "given": "Giovanni", "initials": "G"}, {"family": "Dal\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Settembre", "given": "Nicla", "initials": "N"}, {"family": "Welp", "given": "Henryk", "initials": "H"}, {"family": "Perrotti", "given": "Andrea", "initials": "A"}, {"family": "Wiebe", "given": "Karsten", "initials": "K"}, {"family": "Leo", "given": "Enrico", "initials": "E"}, {"family": "Loforte", "given": "Antonio", "initials": "A"}, {"family": "Chocron", "given": "Sidney", "initials": "S"}, {"family": "Pacini", "given": "Davide", "initials": "D"}, {"family": "Juvonen", "given": "Tatu", "initials": "T"}, {"family": "Broman", "given": "L Mikael", "initials": "LM"}, {"family": "Perna", "given": "Dario Di", "initials": "DD"}, {"family": "Yusuff", "given": "Hakeem", "initials": "H"}, {"family": "Harvey", "given": "Chris", "initials": "C"}, {"family": "Mongardon", "given": "Nicolas", "initials": "N"}, {"family": "Maureira", "given": "Juan P", "initials": "JP"}, {"family": "Levy", "given": "Bruno", "initials": "B"}, {"family": "Falk", "given": "Lars", "initials": "L"}, {"family": "Ruggieri", "given": "Vito G", "initials": "VG"}, {"family": "Zipfel", "given": "Svante", "initials": "S"}, {"family": "Folliguet", "given": "Thierry", "initials": "T"}, {"family": "Fiore", "given": "Antonio", "initials": "A"}], "type": "journal article", "published": "2021-01-19", "journal": {"title": "J Cardiothorac Vasc Anesth", "issn": "1532-8422", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The authors evaluated the outcome of adult patients with coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS) requiring the use of extracorporeal membrane oxygenation (ECMO).\r\n\r\nMulticenter retrospective, observational study.\r\n\r\nTen tertiary referral university and community hospitals.\r\n\r\nPatients with confirmed severe COVID-19-related ARDS.\r\n\r\nVenovenous or venoarterial ECMO.\r\n\r\nOne hundred thirty-two patients (mean age 51.1 \u00b1 9.7 years, female 17.4%) were treated with ECMO for confirmed severe COVID-19-related ARDS. Before ECMO, the mean Sequential Organ Failure Assessment score was 10.1 \u00b1 4.4, mean pH was 7.23 \u00b1 0.09, and mean PaO 2/fraction of inspired oxygen ratio was 77 \u00b1 50 mmHg. Venovenous ECMO was adopted in 122 patients (92.4%) and venoarterial ECMO in ten patients (7.6%) (mean duration, 14.6 \u00b1 11.0 days). Sixty-three (47.7%) patients died on ECMO and 70 (53.0%) during the index hospitalization. Six-month all-cause mortality was 53.0%. Advanced age (per year, hazard ratio [HR] 1.026, 95% CI 1.000-1-052) and low arterial pH (per unit, HR 0.006, 95% CI 0.000-0.083) before ECMO were the only baseline variables associated with increased risk of six-month mortality.\r\n\r\nThe present findings suggested that about half of adult patients with severe COVID-19-related ARDS can be managed successfully with ECMO with sustained results at six months. Decreased arterial pH before ECMO was associated significantly with early mortality. Therefore, the authors hypothesized that initiation of ECMO therapy before severe metabolic derangements subset may improve survival rates significantly in these patients. These results should be viewed in the light of a strict patient selection policy and may not be replicated in patients with advanced age or multiple comorbidities.\r\n\r\nidentifier, NCT04383678.", "doi": "10.1053/j.jvca.2021.01.027", "pmid": "33573928", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1053-0770(21)00062-8"}, {"db": "ClinicalTrials.gov", "key": "NCT04383678", "description": null}], "notes": [], "created": "2021-02-15T17:22:42.437Z", "modified": "2021-06-18T10:58:38.790Z"}, {"entity": "publication", "iuid": "5ade1e95279441e0bb8db1a9d3d813fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5ade1e95279441e0bb8db1a9d3d813fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5ade1e95279441e0bb8db1a9d3d813fa"}}, "title": "Nursing students' experiences of a pedagogical transition from campus learning to distance learning using digital tools.", "authors": [{"family": "Langeg\u00e5rd", "given": "Ulrica", "initials": "U"}, {"family": "Kiani", "given": "Kiana", "initials": "K"}, {"family": "Nielsen", "given": "Susanne J", "initials": "SJ"}, {"family": "Svensson", "given": "Per-Arne", "initials": "P"}], "type": "journal article", "published": "2021-01-19", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "issn-l": null, "volume": "20", "issue": "1", "pages": "23"}, "abstract": "The use of distance education using digital tools in higher education has increased over the last decade, particularly during the COVID-19 pandemic. Therefore, this study aimed to describe and evaluate nursing students' experiences of the pedagogical transition from traditional campus based learning to distance learning using digital tools.\r\n\r\nThe nursing course Symptom and signs of illness underwent a transition from campus based education to distance learning using digital tools because of the COVID-19 pandemic. This pedagogical transition in teaching was evaluated using both quantitative and qualitative data analysis. Focus group interviews (n = 9) were analysed using qualitative content analysis to explore students' experiences of the pedagogical transition and to construct a web-based questionnaire. The questionnaire comprised 14 items, including two open-ended questions. The questionnaire was delivered to all course participants and responses were obtained from 96 of 132 students (73%). Questionnaire data were analyzed using descriptive statistics and comments from the open-ended questions were used as quotes to highlight the quantitative data.\r\n\r\nThe analysis of the focus group interviews extracted three main dimensions: didactic aspects of digital teaching, study environment, and students' own resources. Social interaction was an overall theme included in all three dimensions. Data from the questionnaire showed that a majority of students preferred campus based education and experienced deterioration in all investigated dimensions after the pedagogical transition. However, approximately one-third of the students appeared to prefer distance learning using digital tools.\r\n\r\nThe main finding was that the pedagogical transition to distance education reduced the possibility for students' social interactions in their learning process. This negatively affected several aspects of their experience of distance learning using digital tools, such as reduced motivation. However, the heterogeneity in the responses suggested that a blended learning approach may offer pedagogical benefits while maintaining an advantageous level of social interaction.", "doi": "10.1186/s12912-021-00542-1", "pmid": "33468132", "labels": {"Type: Journal article": null, "Research Area: High-throughput and high-content serology": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12912-021-00542-1"}, {"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-22T09:14:27.260Z", "modified": "2021-06-18T11:10:06.280Z"}, {"entity": "publication", "iuid": "f0e04cdd04a8471ebde402406ab8ab24", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f0e04cdd04a8471ebde402406ab8ab24.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f0e04cdd04a8471ebde402406ab8ab24"}}, "title": "Human species D adenovirus hexon capsid protein mediates cell entry through a direct interaction with CD46.", "authors": [{"family": "Persson", "given": "B David", "initials": "BD"}, {"family": "John", "given": "Lijo", "initials": "L"}, {"family": "Rafie", "given": "Karim", "initials": "K"}, {"family": "Strebl", "given": "Michael", "initials": "M"}, {"family": "Fr\u00e4ngsmyr", "given": "Lars", "initials": "L"}, {"family": "Ballmann", "given": "Monika Z", "initials": "MZ"}, {"family": "Mindler", "given": "Katja", "initials": "K"}, {"family": "Havenga", "given": "Menzo", "initials": "M"}, {"family": "Lemckert", "given": "Angelique", "initials": "A"}, {"family": "Stehle", "given": "Thilo", "initials": "T"}, {"family": "Carlson", "given": "Lars-Anders", "initials": "LA"}, {"family": "Arnberg", "given": "Niklas", "initials": "N"}], "type": "journal article", "published": "2021-01-19", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "118", "issue": "3", "issn-l": "0027-8424"}, "abstract": "Human adenovirus species D (HAdV-D) types are currently being explored as vaccine vectors for coronavirus disease 2019 (COVID-19) and other severe infectious diseases. The efficacy of such vector-based vaccines depends on functional interactions with receptors on host cells. Adenoviruses of different species are assumed to enter host cells mainly by interactions between the knob domain of the protruding fiber capsid protein and cellular receptors. Using a cell-based receptor-screening assay, we identified CD46 as a receptor for HAdV-D56. The function of CD46 was validated in infection experiments using cells lacking and overexpressing CD46, and by competition infection experiments using soluble CD46. Remarkably, unlike HAdV-B types that engage CD46 through interactions with the knob domain of the fiber protein, HAdV-D types infect host cells through a direct interaction between CD46 and the hexon protein. Soluble hexon proteins (but not fiber knob) inhibited HAdV-D56 infection, and surface plasmon analyses demonstrated that CD46 binds to HAdV-D hexon (but not fiber knob) proteins. Cryoelectron microscopy analysis of the HAdV-D56 virion-CD46 complex confirmed the interaction and showed that CD46 binds to the central cavity of hexon trimers. Finally, soluble CD46 inhibited infection by 16 out of 17 investigated HAdV-D types, suggesting that CD46 is an important receptor for a large group of adenoviruses. In conclusion, this study identifies a noncanonical entry mechanism used by human adenoviruses, which adds to the knowledge of adenovirus biology and can also be useful for development of adenovirus-based vaccine vectors.", "doi": "10.1073/pnas.2020732118", "pmid": "33384338", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "2020732118"}, {"db": "PDB", "key": "7AJP", "description": "Crystal Structure of Human Adenovirus 56 Fiber Knob"}], "notes": [], "created": "2021-01-07T11:46:55.276Z", "modified": "2021-03-08T13:05:30.572Z"}, {"entity": "publication", "iuid": "19be7cdb189c4ea5b5d140fccdbc9908", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19be7cdb189c4ea5b5d140fccdbc9908.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19be7cdb189c4ea5b5d140fccdbc9908"}}, "title": "Psychological Impact of COVID-19 Cases on Medical Staff of Beijing Xiaotangshan Hospital.", "authors": [{"family": "Fu", "given": "Yuanbo", "initials": "Y"}, {"family": "Wang", "given": "Mina", "initials": "M"}, {"family": "Zhao", "given": "Bingcong", "initials": "B"}, {"family": "Liu", "given": "Baoli", "initials": "B"}, {"family": "Sun", "given": "Jie", "initials": "J"}, {"family": "Feng", "given": "Yaohui", "initials": "Y"}, {"family": "Wang", "given": "Zhengfang", "initials": "Z"}, {"family": "Li", "given": "Qian", "initials": "Q"}, {"family": "Shi", "given": "Chunhong", "initials": "C"}, {"family": "Xuan", "given": "Yabo", "initials": "Y"}, {"family": "Long", "given": "Siqi", "initials": "S"}, {"family": "Liu", "given": "Huan", "initials": "H"}, {"family": "Chi", "given": "Tiange", "initials": "T"}, {"family": "Liao", "given": "Zehuan", "initials": "Z"}, {"family": "Li", "given": "Bin", "initials": "B"}, {"family": "Liu", "given": "Qingquan", "initials": "Q"}], "type": "journal article", "published": "2021-01-18", "journal": {"title": "Psychol Res Behav Manag", "issn": "1179-1578", "volume": "14", "issue": null, "pages": "41-47", "issn-l": null}, "abstract": "To investigate the psychological impact of cases of coronavirus disease 19 (COVID-19) on medical staff of Beijing Xiaotangshan Hospital.\n\nThe 287 online questionnaires were distributed to medical staff working at Beijing Xiaotangshan Hospital, comprising three main sections and 17 questions: basic information, current departmental position, and the 12-item General Health Questionnaire (GHQ-12). The threshold for emotional distress was defined to be a total score of 4 on the GHQ-12 and above.\n\nA total of 255 members of medical staff participating in this study presented an emotional distress rate of 17%. Members who were male, aged 50-59, married with children, positioned as doctors, and in administration were the population with the highest rate of emotional distress. Furthermore, the severity of emotional distress among those under 30 was significantly lower than those aged 30-39 and 50-59. Doctors and other occupations shared a lower level of satisfaction on routine activities compared with nurses, so did staff in the administration compared with those who were working in screening or logistic departments. Besides, males and staff of the confirmation department had more difficulty in concentrating than females and those of the screening department, respectively.\n\nMedical staff working at Xiaotangshan Hospital underwent relatively low levels of emotional distress thanks to sufficient medical and psychological preparations. However, special attention should be paid to those who were male, married with children, senior, doctors, in administration, and in the confirmation department.", "doi": "10.2147/PRBM.S287842", "pmid": "33500670", "labels": {"Type: Journal article": null, "Category: Proteins": null}, "xrefs": [{"db": "pii", "key": "287842"}, {"db": "pmc", "key": "PMC7822226"}], "notes": [], "created": "2021-01-29T15:20:19.301Z", "modified": "2021-02-26T08:47:18.761Z"}, {"entity": "publication", "iuid": "de8e43af8fbc4fce91a5e2e0a2f872d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/de8e43af8fbc4fce91a5e2e0a2f872d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/de8e43af8fbc4fce91a5e2e0a2f872d5"}}, "title": "Unrecognized risks and challenges of water as a major focus of COVID-19 spread.", "authors": [{"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}, {"family": "Burkle", "given": "Frederick M", "initials": "FM"}], "type": "journal article", "published": "2021-01-16", "journal": {"title": "J Glob Health", "issn": "2047-2986", "volume": "11", "issue": null, "pages": "03016", "issn-l": "2047-2978"}, "abstract": null, "doi": "10.7189/jogh.11.03016", "pmid": "33643626", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jogh-11-03016"}, {"db": "pmc", "key": "PMC7898659"}], "notes": [], "created": "2021-03-02T06:55:40.108Z", "modified": "2021-03-02T06:55:40.119Z"}, {"entity": "publication", "iuid": "db584bed80c945d6a6c6def84a90cf1b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db584bed80c945d6a6c6def84a90cf1b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db584bed80c945d6a6c6def84a90cf1b"}}, "title": "Sleep in Female Healthcare Workers during COVID-19: A Cross-sectional Survey Study in Sweden during the Flattening of the First Wave of the Pandemic.", "authors": [{"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J"}], "type": "journal article", "published": "2021-01-15", "journal": {"title": "Ann Am Thorac Soc", "issn": "2325-6621", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1513/AnnalsATS.202101-019RL", "pmid": "33448898", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-18T14:37:02.564Z", "modified": "2021-01-18T14:37:02.581Z"}, {"entity": "publication", "iuid": "cb790b6fefa748598789c57ca0388216", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cb790b6fefa748598789c57ca0388216.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cb790b6fefa748598789c57ca0388216"}}, "title": "Serum Renin Levels Increase With Age in Boys Resulting in Higher Renin Levels in Young Men Compared to Young Women, and Soluble Angiotensin-Converting Enzyme 2 Correlates With Renin and Body Mass Index.", "authors": [{"family": "Jehpsson", "given": "Lars", "initials": "L"}, {"family": "Sun", "given": "Jiangming", "initials": "J"}, {"family": "Nilsson", "given": "Peter M", "initials": "PM"}, {"family": "Edsfeldt", "given": "Andreas", "initials": "A"}, {"family": "Sw\u00e4rd", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2021-01-15", "journal": {"title": "Front Physiol", "issn": "1664-042X", "issn-l": null, "volume": "11", "issue": null, "pages": "622179"}, "abstract": "Background: Age, sex, and body constitution may affect the shedding of membrane bound angiotensin-converting enzyme 2 (mACE2) and lead to a relative mACE2 deficiency. However, it is unclear if differences, reflected by serum renin levels, exist in the basal renin-angiotensin-system (RAS) between children and adults, boys, and girls as well as young women and young men. Furthermore, it remains to be investigated if renin and soluble ACE2 (sACE2) levels are correlated with body mass index (BMI) in children and young adults. The aim of this observational study was to assess age-and sex differences in serum renin, and the relationship between renin, soluble angiotensin-converting enzyme 2, and body mass index in a prospectively followed population-based cohort of children which were followed into young adulthood. Study Design: We analyzed renin and sACE2 in serum in a prospectively followed population-based cohort at 9.9 (0.6) [mean (SD)] (n = 173), 11.7 (0.6) (n = 156), 14.8 (0.8) (n = 149), 18.8 (0.3) (n = 93), and 23.5 (0.7) (n = 152) years of age. Height (cm) and weight (kg) was measured and body mass index (BMI) was calculated as weight (kg)/height (m)2. Sex-related differences in renin levels were calculated using analysis of covariance, adjusted for age. Correlations were assessed by calculating the correlation coefficient (R2) using a multivariable linear mixed model. Results: Both sexes had low renin levels up to 12 years of age. Thereafter renin levels increased more in boys than in girls. Males from the age of 15 had significantly higher levels than females (p < 0.001). There was a positive linear relationship between renin and sACE2 levels in male and female subjects (p < 0.001), and between sACE2 levels and BMI in males (p < 0.001). Conclusion: Renin levels increase with age, are higher in men than in women since around puberty, and are correlated with sACE2 levels. Furthermore, sACE2 levels are correlated with body mass index in males. These findings indicate that high renin levels in males and females and a high BMI in males may activate pathways which increase the shedding of mACE2, with possible implications for the risk of severe coronavirus disease 2019.", "doi": "10.3389/fphys.2020.622179", "pmid": "33519526", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7844344"}], "notes": [], "created": "2021-02-04T18:35:07.586Z", "modified": "2021-06-18T10:52:15.052Z"}, {"entity": "publication", "iuid": "8f2208ef80cc47daaf609e804bba5feb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f2208ef80cc47daaf609e804bba5feb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f2208ef80cc47daaf609e804bba5feb"}}, "title": "Elevated Angiopoietin-2 inhibits thrombomodulin-mediated anticoagulation in critically ill COVID-19 patients", "authors": [{"family": "Hultstrom", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Fromell", "given": "Karin", "initials": "K", "orcid": "0000-0001-8905-8791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9342eb4305954aba853bdf3a8153ab67.json"}}, {"family": "Larsson", "given": "Anders", "initials": "A", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2be858ab604743b72383dfdcd14689.json"}}, {"family": "Quaggin", "given": "Susan E", "initials": "SE", "orcid": "0000-0002-3706-5727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a72116a70bfc48a69063ca0d3454123f.json"}}, {"family": "Betsholtz", "given": "Christer", "initials": "C", "orcid": "0000-0002-8494-971X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22ce9638bcd9467d812ca8adc65001d4.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Jeansson", "given": "Marie", "initials": "M", "orcid": "0000-0003-1075-8563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae2c63715b0f4a5b8127552ab84a1bf3.json"}}], "type": "posted-content", "published": "2021-01-15", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.01.13.21249429", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.17044/scilifelab.14229410.v1", "description": "Metadata record"}], "notes": [], "created": "2021-01-18T18:27:26.562Z", "modified": "2021-12-12T18:07:08.439Z"}, {"entity": "publication", "iuid": "9fa7133f2c2b4605b375cd6003754209", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9fa7133f2c2b4605b375cd6003754209.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9fa7133f2c2b4605b375cd6003754209"}}, "title": "Utilisation, Availability and Price Changes of Medicines and Protection Equipment for COVID-19 Among Selected Regions in India: Findings and Implications", "authors": [{"family": "Haque", "given": "Mainul", "initials": "M"}, {"family": "Kumar", "given": "Santosh", "initials": "S"}, {"family": "Charan", "given": "Jaykaran", "initials": "J"}, {"family": "Bhatt", "given": "Rohan", "initials": "R"}, {"family": "Islam", "given": "Salequl", "initials": "S"}, {"family": "Dutta", "given": "Siddhartha", "initials": "S"}, {"family": "Abhayanand", "given": "Jha Pallavi", "initials": "JP"}, {"family": "Sharma", "given": "Yesh", "initials": "Y"}, {"family": "Sefah", "given": "Israel", "initials": "I"}, {"family": "Kurdi", "given": "Amanj", "initials": "A"}, {"family": "Wale", "given": "Janney", "initials": "J"}, {"family": "Godman", "given": "Brian", "initials": "B"}], "type": "journal-article", "published": "2021-01-14", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "11", "issue": null, "pages": null, "issn-l": "1663-9812"}, "abstract": null, "doi": "10.3389/fphar.2020.582154", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-25T12:36:36.412Z", "modified": "2021-02-26T08:47:00.115Z"}, {"entity": "publication", "iuid": "e44cd62c93dc4ec5a51853a95aa15322", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e44cd62c93dc4ec5a51853a95aa15322.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e44cd62c93dc4ec5a51853a95aa15322"}}, "title": "The Impact of COVID-19 on In-Hospital Outcomes of ST-Segment Elevation Myocardial Infarction Patients.", "authors": [{"family": "Ayad", "given": "Sherif", "initials": "S"}, {"family": "Shenouda", "given": "Rafik", "initials": "R"}, {"family": "Henein", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2021-01-14", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "10", "issue": "2", "pages": null}, "abstract": "Primary percutaneous coronary intervention (PPCI) is one of the important clinical procedures that have been affected by the COVID-19 pandemic. In this study, we aimed to assess the incidence and impact of COVID-19 on in-hospital clinical outcome of ST elevation myocardial infarction (STEMI) patients managed with PPCI. This observational retrospective study was conducted on consecutive STEMI patients who presented to the International Cardiac Center (ICC) hospital, Alexandria, Egypt between 1 February and 31 October 2020. A group of STEMI patients presented during the same period in 2019 was also assessed (control group) and data was used for comparison. The inclusion criteria were established diagnosis of STEMI requiring PPCI.A total of 634 patients were included in the study. During the COVID-19 period, the number of PPCI procedures was reduced by 25.7% compared with previous year (mean 30.0 \u00b1 4.01 vs. 40.4 \u00b1 5.3 case/month) and the time from first medical contact to Needle (FMC-to-N) was longer (125.0 \u00b1 53.6 vs. 52.6 \u00b1 22.8 min, p = 0.001). Also, during COVID-19, the in-hospital mortality was higher (7.4 vs. 4.6%, p = 0.036) as was the incidence of re-infarction (12.2 vs. 7.7%, p = 0.041) and the need for revascularization (15.9 vs. 10.7%, p = 0.046). The incidence of heart failure, stroke, and bleeding was not different between groups, but hospital stay was longer during COVID-19 (6.85 \u00b1 4.22 vs. 3.5 \u00b1 2.3 day, p = 0.0025). Conclusion: At the ICC, COVID-19 pandemic contributed significantly to the PPCI management of STEMI patients with decreased number and delayed procedures. COVID-19 was also associated with higher in-hospital mortality, rate of re-infarction, need for revascularization, and longer hospital stay.", "doi": "10.3390/jcm10020278", "pmid": "33466588", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "jcm10020278"}], "notes": [], "created": "2021-01-22T09:16:39.182Z", "modified": "2021-06-18T10:51:57.424Z"}, {"entity": "publication", "iuid": "9ffbffb4b03446888ea96e3df6f24fa8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ffbffb4b03446888ea96e3df6f24fa8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ffbffb4b03446888ea96e3df6f24fa8"}}, "title": "Self-Perceived Changes in Physical Activity and the Relation to Life Satisfaction and Rated Physical Capacity in Swedish Adults during the COVID-19 Pandemic-A Cross Sectional Study.", "authors": [{"family": "Eek", "given": "Frida", "initials": "F"}, {"family": "Larsson", "given": "Caroline", "initials": "C"}, {"family": "Wis\u00e9n", "given": "Anita", "initials": "A"}, {"family": "Ekvall Hansson", "given": "Eva", "initials": "E"}], "type": "journal article", "published": "2021-01-14", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "2", "pages": null}, "abstract": "COVID-19 restrictions may prevent people from reaching recommended levels of physical activity (PA). This study examines self-perceived changes in the extent and intensity of PA during the COVID-19 pandemic, and the relation between perceived changes in PA and general life satisfaction and perceived physical capacity. A total of 1318 participants (mean age 47.8 SD12.6; 82.1% women) were recruited through social media in Sweden during autumn 2020. The survey included questions regarding perceived changes in PA compared to the previous year, the \"Rating of Perceived Capacity\" scale and \"Life Satisfaction Questionnaire-11\". A change in PA was reported by 65% of participants. More participants reported an increase (36%) than a decrease (29%), however a decrease in PA was significantly more often considered to be due to the pandemic. The highest odds of decreased PA was found in the oldest age group (70+ years) (OR 2.8; 95% CI 1.4-5.7). Those who reported decreased levels of PA reported lower life satisfaction and aerobic capacity than the other groups ( p > 0.001). Decreased physical activity was reported by many, but an equal share reported increased activity during the pandemic. The highest odds for decreased activity was found in the oldest group-the group that has been subjected to the strictest recommended COVID-19 restrictions in Sweden.", "doi": "10.3390/ijerph18020671", "pmid": "33466860", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph18020671"}], "notes": [], "created": "2021-01-22T09:15:10.766Z", "modified": "2021-06-18T11:03:45.303Z"}, {"entity": "publication", "iuid": "be702d32c1414faf947340a12462b206", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be702d32c1414faf947340a12462b206.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be702d32c1414faf947340a12462b206"}}, "title": "SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice", "authors": [{"family": "Tian", "given": "Jing Hui", "initials": "JH"}, {"family": "Patel", "given": "Nita", "initials": "N"}, {"family": "Haupt", "given": "Robert", "initials": "R"}, {"family": "Zhou", "given": "Haixia", "initials": "H"}, {"family": "Weston", "given": "Stuart", "initials": "S"}, {"family": "Hammond", "given": "Holly", "initials": "H"}, {"family": "Logue", "given": "James", "initials": "J"}, {"family": "Portnoff", "given": "Alyse D", "initials": "AD"}, {"family": "Norton", "given": "James", "initials": "J"}, {"family": "Guebre-Xabier", "given": "Mimi", "initials": "M"}, {"family": "Zhou", "given": "Bin", "initials": "B"}, {"family": "Jacobson", "given": "Kelsey", "initials": "K"}, {"family": "Maciejewski", "given": "Sonia", "initials": "S"}, {"family": "Khatoon", "given": "Rafia", "initials": "R"}, {"family": "Wisniewska", "given": "Malgorzata", "initials": "M"}, {"family": "Moffitt", "given": "Will", "initials": "W"}, {"family": "Kluepfel-Stahl", "given": "Stefanie", "initials": "S"}, {"family": "Ekechukwu", "given": "Betty", "initials": "B"}, {"family": "Papin", "given": "James", "initials": "J"}, {"family": "Boddapati", "given": "Sarathi", "initials": "S"}, {"family": "Jason Wong", "given": "C", "initials": "C"}, {"family": "Piedra", "given": "Pedro A", "initials": "PA"}, {"family": "Frieman", "given": "Matthew B", "initials": "MB"}, {"family": "Massare", "given": "Michael J", "initials": "MJ"}, {"family": "Fries", "given": "Louis", "initials": "L"}, {"family": "Bengtsson", "given": "Karin L\u00f6vgren", "initials": "KL"}, {"family": "Stertman", "given": "Linda", "initials": "L"}, {"family": "Ellingsworth", "given": "Larry", "initials": "L"}, {"family": "Glenn", "given": "Gregory", "initials": "G"}, {"family": "Smith", "given": "Gale", "initials": "G"}], "type": "journal-article", "published": "2021-01-14", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "372"}, "abstract": "The COVID-19 pandemic continues to spread throughout the world with an urgent need for a safe and protective vaccine to effectuate herd protection and control the spread of SARS-CoV-2. Here, we report the development of a SARS-CoV-2 subunit vaccine (NVX-CoV2373) from the full-length spike (S) protein that is stable in the prefusion conformation. NVX-CoV2373 S form 27.2-nm nanoparticles that are thermostable and bind with high affinity to the human angiotensin-converting enzyme 2 (hACE2) receptor. In mice, low-dose NVX-CoV2373 with saponin-based Matrix-M adjuvant elicit high titer anti-S IgG that blocks hACE2 receptor binding, neutralize virus, and protects against SARS-CoV-2 challenge with no evidence of vaccine-associated enhanced respiratory disease. NVX-CoV2373 also elicits multifunctional CD4 + and CD8+ T cells, CD4+ follicular helper T cells (Tfh), and antigen-specific germinal center (GC) B cells in the spleen. In baboons, low-dose levels of NVX-CoV2373 with Matrix-M was also highly immunogenic and elicited high titer anti-S antibodies and functional antibodies that block S-protein binding to hACE2 and neutralize virus infection and antigen-specific T cells. These results support the ongoing phase 1/2 clinical evaluation of the safety and immunogenicity of NVX-CoV2373 with Matrix-M (NCT04368988).", "doi": "10.1038/s41467-020-20653-8", "pmid": "33446655", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null, "Category: Vaccines": null}, "xrefs": [{"db": "URL", "key": "https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-020-20653-8/MediaObjects/41467_2020_20653_MOESM4_ESM.xlsx", "description": "Various raw data"}], "notes": [], "created": "2021-01-15T13:07:39.769Z", "modified": "2021-12-07T15:31:17.780Z"}, {"entity": "publication", "iuid": "eabd601758b541d6964027948b408314", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eabd601758b541d6964027948b408314.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eabd601758b541d6964027948b408314"}}, "title": "Real-time monitoring shows substantial excess all-cause mortality during second wave of COVID-19 in Europe, October to December 2020", "authors": [{"family": "N\u00f8rgaard", "given": "Sarah K", "initials": "SK"}, {"family": "Vestergaard", "given": "Lasse S", "initials": "LS"}, {"family": "Nielsen", "given": "Jens", "initials": "J"}, {"family": "Richter", "given": "Lukas", "initials": "L"}, {"family": "Schmid", "given": "Daniela", "initials": "D"}, {"family": "Bustos", "given": "Natalia", "initials": "N"}, {"family": "Braye", "given": "Toon", "initials": "T"}, {"family": "Athanasiadou", "given": "Maria", "initials": "M"}, {"family": "Lytras", "given": "Theodore", "initials": "T"}, {"family": "Denissov", "given": "Gleb", "initials": "G"}, {"family": "Veideman", "given": "Tatjana", "initials": "T"}, {"family": "Luomala", "given": "Oskari", "initials": "O"}, {"family": "M\u00f6tt\u00f6nen", "given": "Teemu", "initials": "T"}, {"family": "Fouillet", "given": "Anne", "initials": "A"}, {"family": "Caserio-Sch\u00f6nemann", "given": "C\u00e9line", "initials": "C"}, {"family": "an der Heiden", "given": "Matthias", "initials": "M"}, {"family": "Uphoff", "given": "Helmut", "initials": "H"}, {"family": "Gkolfinopoulou", "given": "Kassiani", "initials": "K"}, {"family": "Bobvos", "given": "Janos", "initials": "J"}, {"family": "Paldy", "given": "Anna", "initials": "A"}, {"family": "Rotem", "given": "Naama", "initials": "N"}, {"family": "Kornilenko", "given": "Irene", "initials": "I"}, {"family": "Domegan", "given": "Lisa", "initials": "L"}, {"family": "O\u2019Donnell", "given": "Joan", "initials": "J"}, {"family": "Donato", "given": "Francesca De", "initials": "FD"}, {"family": "Scortichini", "given": "Matteo", "initials": "M"}, {"family": "Hoffmann", "given": "Patrick", "initials": "P"}, {"family": "Velez", "given": "Telma", "initials": "T"}, {"family": "England", "given": "Kathleen", "initials": "K"}, {"family": "Calleja", "given": "Neville", "initials": "N"}, {"family": "van Asten", "given": "Liselotte", "initials": "L"}, {"family": "Stoeldraijer", "given": "Lenny", "initials": "L"}, {"family": "White", "given": "Richard A", "initials": "RA"}, {"family": "Paulsen", "given": "Trine H", "initials": "TH"}, {"family": "da Silva", "given": "Susana P", "initials": "SP"}, {"family": "Rodrigues", "given": "Ana P", "initials": "AP"}, {"family": "Klepac", "given": "Petra", "initials": "P"}, {"family": "Zaletel", "given": "Metka", "initials": "M"}, {"family": "Fafangel", "given": "Mario", "initials": "M"}, {"family": "Larrauri", "given": "Amparo", "initials": "A"}, {"family": "Le\u00f3n", "given": "Inmaculada", "initials": "I"}, {"family": "Farah", "given": "Ahmed", "initials": "A"}, {"family": "Galanis", "given": "Ilias", "initials": "I"}, {"family": "Junker", "given": "Christoph", "initials": "C"}, {"family": "Perisa", "given": "Damir", "initials": "D"}, {"family": "Sinnathamby", "given": "Mary", "initials": "M"}, {"family": "Andrews", "given": "Nick", "initials": "N"}, {"family": "O'Doherty", "given": "Mark G", "initials": "MG"}, {"family": "Irwin", "given": "David", "initials": "D"}, {"family": "Kennedy", "given": "Sharon", "initials": "S"}, {"family": "McMenamin", "given": "Jim", "initials": "J"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Penttinen", "given": "Pasi", "initials": "P"}, {"family": "Pukkila", "given": "Jukka", "initials": "J"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "Krause", "given": "Tyra G", "initials": "TG"}, {"family": "M\u00f8lbak", "given": "K\u00e5re", "initials": "K"}], "type": "journal-article", "published": "2021-01-14", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "2", "pages": null}, "abstract": "The European monitoring of excess mortality for public health action (EuroMOMO) network monitors weekly excess all-cause mortality in 27 European countries or subnational areas. During the first wave of the coronavirus disease (COVID-19) pandemic in Europe in spring 2020, several countries experienced extraordinarily high levels of excess mortality. Europe is currently seeing another upsurge in COVID-19 cases, and EuroMOMO is again witnessing a substantial excess all-cause mortality attributable to COVID-19.", "doi": "10.2807/1560-7917.es.2021.26.1.2002023", "pmid": "33446304", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-15T13:12:07.264Z", "modified": "2021-06-18T10:59:36.865Z"}, {"entity": "publication", "iuid": "d1739e47fac748278f5a49d715423cc6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1739e47fac748278f5a49d715423cc6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1739e47fac748278f5a49d715423cc6"}}, "title": "Rapid Assessment of the Potential Paucity and Price Increases for Suggested Medicines and Protection Equipment for COVID-19 Across Developing Countries With a Particular Focus on Africa and the Implications", "authors": [{"family": "Sefah", "given": "Israel Abebrese", "initials": "IA"}, {"family": "Ogunleye", "given": "Olayinka O", "initials": "OO"}, {"family": "Essah", "given": "Darius Obeng", "initials": "DO"}, {"family": "Opanga", "given": "Sylvia A", "initials": "SA"}, {"family": "Butt", "given": "Nadia", "initials": "N"}, {"family": "Wamaitha", "given": "Annie", "initials": "A"}, {"family": "Guantai", "given": "Anastasia Nkatha", "initials": "AN"}, {"family": "Chikowe", "given": "Ibrahim", "initials": "I"}, {"family": "Khuluza", "given": "Felix", "initials": "F"}, {"family": "Kibuule", "given": "Dan", "initials": "D"}, {"family": "Nambahu", "given": "Lahya", "initials": "L"}, {"family": "Abubakar", "given": "Abdullahi Rabiu", "initials": "AR"}, {"family": "Sani", "given": "Ibrahim Haruna", "initials": "IH"}, {"family": "Saleem", "given": "Zikria", "initials": "Z"}, {"family": "Kalungia", "given": "Aubrey C", "initials": "AC"}, {"family": "Thi Phuong", "given": "Thuy Nguyen", "initials": "TN"}, {"family": "Haque", "given": "Mainul", "initials": "M"}, {"family": "Islam", "given": "Salequl", "initials": "S"}, {"family": "Kumar", "given": "Santosh", "initials": "S"}, {"family": "Sneddon", "given": "Jacqueline", "initials": "J"}, {"family": "Wamboga", "given": "Joshua", "initials": "J"}, {"family": "Wale", "given": "Janney", "initials": "J"}, {"family": "Miljkovi\u0107", "given": "Nenad", "initials": "N"}, {"family": "Kurdi", "given": "Amanj", "initials": "A"}, {"family": "Martin", "given": "Antony P", "initials": "AP"}, {"family": "Godman", "given": "Brian", "initials": "B"}], "type": "journal-article", "published": "2021-01-14", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "11", "issue": null, "pages": null, "issn-l": "1663-9812"}, "abstract": null, "doi": "10.3389/fphar.2020.588106", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-25T12:33:08.337Z", "modified": "2021-02-26T08:47:00.209Z"}, {"entity": "publication", "iuid": "8a9fd3c3b0244e3e81860d7dc98d9a3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a9fd3c3b0244e3e81860d7dc98d9a3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a9fd3c3b0244e3e81860d7dc98d9a3d"}}, "title": "Malpractice claimed calls within the Swedish Healthcare Direct: a descriptive \u2013 comparative case study", "authors": [{"family": "Bj\u00f6rkman", "given": "Annica", "initials": "A"}, {"family": "Engstr\u00f6m", "given": "Maria", "initials": "M"}, {"family": "Winblad", "given": "Ulrika", "initials": "U"}, {"family": "Holmstr\u00f6m", "given": "Inger K", "initials": "IK"}], "type": "journal-article", "published": "2021-01-14", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "issn-l": null, "volume": "20", "issue": "1", "pages": null}, "abstract": null, "doi": "10.1186/s12912-021-00540-3", "pmid": "33446213", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-15T13:13:41.154Z", "modified": "2021-06-18T11:06:59.592Z"}, {"entity": "publication", "iuid": "5e357bc3280e4a6c8fb860e54818e86c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e357bc3280e4a6c8fb860e54818e86c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e357bc3280e4a6c8fb860e54818e86c"}}, "title": "Stress und Covid-19: Ein Narrativer Review \u00fcber neuroendokrin-immune Mechanismen, die eine Abwehr von SARS-CoV-2 verbessern k\u00f6nnten", "authors": [{"family": "Peters", "given": "Eva Milena Johanne", "initials": "EMJ"}, {"family": "Schedlowski", "given": "Manfred", "initials": "M"}, {"family": "Watzl", "given": "Carsten", "initials": "C"}, {"family": "Gimsa", "given": "Ulrike", "initials": "U"}], "type": "journal-article", "published": "2021-01-13", "journal": {"title": "Psychother Psychosom Med Psychol", "issn": "0937-2032", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1055/a-1322-3205", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-15T13:16:23.754Z", "modified": "2021-02-26T08:46:59.974Z"}, {"entity": "publication", "iuid": "f856eeca79fd4a1c8b49192f0f2fe7e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f856eeca79fd4a1c8b49192f0f2fe7e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f856eeca79fd4a1c8b49192f0f2fe7e7"}}, "title": "Distinct lung-homing receptor expression and activation profiles on NK cell and T cell subsets in COVID-19 and influenza", "authors": [{"family": "Brownlie", "given": "Demi", "initials": "D"}, {"family": "R\u00f8dahl", "given": "Inga", "initials": "I"}, {"family": "Varnaite", "given": "Renata", "initials": "R"}, {"family": "Asgeirsson", "given": "Hilmir", "initials": "H"}, {"family": "Glans", "given": "Hedvig", "initials": "H"}, {"family": "Falck-Jones", "given": "Sara", "initials": "S"}, {"family": "Vangeti", "given": "Sindhu", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Ljunggren", "given": "Hans Gustaf", "initials": "HG"}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Marquardt", "given": "Nicole", "initials": "N"}], "type": "posted-content", "published": "2021-01-13", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.01.13.426553", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-15T14:19:16.762Z", "modified": "2022-06-21T18:22:46.189Z"}, {"entity": "publication", "iuid": "c7d80c74ef2c4621be717f223c622d54", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7d80c74ef2c4621be717f223c622d54.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7d80c74ef2c4621be717f223c622d54"}}, "title": "COVID-19 after kidney transplantation: Early outcome and renal function following antiviral treatment.", "authors": [{"family": "Elec", "given": "Alina Daciana", "initials": "AD"}, {"family": "Oltean", "given": "Mihai", "initials": "M"}, {"family": "Goldis", "given": "Patricia", "initials": "P"}, {"family": "Cismaru", "given": "Cristina", "initials": "C"}, {"family": "Lupse", "given": "Mihaela", "initials": "M"}, {"family": "Muntean", "given": "Adriana", "initials": "A"}, {"family": "Elec", "given": "Florin Ioan", "initials": "FI"}], "type": "journal article", "published": "2021-01-13", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "volume": null, "issue": null, "issn-l": "1201-9712"}, "abstract": "The lack of effective COVID-19 treatments mandated the repurposing of several drugs, including antiretrovirals (ARV) and remdesivir (RDV). These compounds may induce acute kidney injuries and are not recommended in patients with poor renal function, such as kidney transplant recipients (KTx).\n\nWe reviewed the records of 42 KTx with COVID-19, some of them receiving ARV (n = 10) or RDV (n = 8) as part of the COVID-19 management. Most patients were male (71%) with a median age of 52 years and median GFR 56 mL/min and had mild (36%), moderate (19%), severe (31%), and critical (12%) disease. Subgroups (patients receiving ARV, RDV, or no antivirals) were comparable regarding patient age, comorbidities or immunosuppression.\n\nSeven patients (16,6%) died during hospitalization. Acute kidney injury was found in 24% KTx at admission. Upon discharge, eGFR increased in 32% and decreased in 39% of the KTx compared with the admission. The decrease was more prevalent in the RDV group (80%) compared with KTx without any antiviral treatment (29%) (p < 0.05). Most patients (62%) returned to baseline eGFR values within one month from discharge. The proportion was similar between the patients receiving antiviral treatment or not.\n\nKTx run a high risk of COVID-19-related renal impairment. Antivirals appear safe for use without major risks for kidney injury.", "doi": "10.1016/j.ijid.2021.01.023", "pmid": "33453396", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)00033-3"}, {"db": "URL", "key": "https://www.ijidonline.com/cms/10.1016/j.ijid.2021.01.023/attachment/10ccf84a-9c50-4457-b428-6a46ea9babe3/mmc1.docx", "description": "Patient demographics, management and outcome in 42 kidney recipients with COVID-19"}], "notes": [], "created": "2021-01-18T14:38:18.532Z", "modified": "2021-06-18T10:44:28.575Z"}, {"entity": "publication", "iuid": "87c1ab20e64f4807aae86b805119e073", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87c1ab20e64f4807aae86b805119e073.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87c1ab20e64f4807aae86b805119e073"}}, "title": "Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape", "authors": [{"family": "Koenig", "given": "Paul Albert", "initials": "PA"}, {"family": "Das", "given": "Hrishikesh", "initials": "H"}, {"family": "Liu", "given": "Hejun", "initials": "H"}, {"family": "K\u00fcmmerer", "given": "Beate M", "initials": "BM"}, {"family": "Gohr", "given": "Florian N", "initials": "FN"}, {"family": "Jenster", "given": "Lea Marie", "initials": "LM"}, {"family": "Schiffelers", "given": "Lisa D J", "initials": "LDJ"}, {"family": "Tesfamariam", "given": "Yonas M", "initials": "YM"}, {"family": "Uchima", "given": "Miki", "initials": "M"}, {"family": "Wuerth", "given": "Jennifer D", "initials": "JD"}, {"family": "Gatterdam", "given": "Karl", "initials": "K"}, {"family": "Ruetalo", "given": "Natalia", "initials": "N"}, {"family": "Christensen", "given": "Maria H", "initials": "MH"}, {"family": "Fandrey", "given": "Caroline I", "initials": "CI"}, {"family": "Normann", "given": "Sabine", "initials": "S"}, {"family": "T\u00f6dtmann", "given": "Jan M P", "initials": "JMP"}, {"family": "Pritzl", "given": "Steffen", "initials": "S"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Boos", "given": "Jannik", "initials": "J"}, {"family": "Yuan", "given": "Meng", "initials": "M"}, {"family": "Zhu", "given": "Xueyong", "initials": "X"}, {"family": "Schmid-Burgk", "given": "Jonathan L", "initials": "JL"}, {"family": "Kato", "given": "Hiroki", "initials": "H"}, {"family": "Schindler", "given": "Michael", "initials": "M"}, {"family": "Wilson", "given": "Ian A", "initials": "IA"}, {"family": "Geyer", "given": "Matthias", "initials": "M"}, {"family": "Ludwig", "given": "Kerstin U", "initials": "KU"}, {"family": "H\u00e4llberg", "given": "B Martin", "initials": "BM"}, {"family": "Wu", "given": "Nicholas C", "initials": "NC"}, {"family": "Schmidt", "given": "Florian I", "initials": "FI"}], "type": "journal-article", "published": "2021-01-12", "journal": {"title": "Science", "issn": "0036-8075", "issn-l": null, "volume": "371", "issue": "6530", "pages": "eabe6230"}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to spread with devastating consequences. For passive immunization efforts, nanobodies have size and cost advantages over conventional antibodies. Here, we generated four neutralizing nanobodies that target the receptor-binding domain of the SARS-CoV-2 spike protein. We defined two distinct binding epitopes using x-ray crystallography and cryo-electron microscopy. Based on the structures, we engineered multivalent nanobodies with more than 100-fold improved neutralizing activity than monovalent nanobodies. Biparatopic nanobody fusions suppressed the emergence of escape mutants. Several nanobody constructs neutralized through receptor-binding competition, while other monovalent and biparatopic nanobodies triggered aberrant activation of the spike fusion machinery. These premature conformational changes in the spike protein forestalled productive fusion, and rendered the virions non-infectious.", "doi": "10.1126/science.abe6230", "pmid": "33436526", "labels": {"Type: Journal article": null, "Funder: H2020": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Imaging": null, "Category: Proteins": null}, "xrefs": [{"db": "PDB", "key": "7KN5", "description": "Crystal structure of SARS-CoV-2 RBD complexed with nanobodies VHH E and U"}, {"db": "PDB", "key": "7KN6", "description": "Crystal structure of SARS-CoV-2 RBD complexed with nanobody VHH V and antibody Fab CC12.3"}, {"db": "PDB", "key": "7KN7", "description": "Crystal structure of SARS-CoV-2 RBD complexed with nanobody VHH W and antibody Fab CC12.3"}, {"db": "URL", "key": "https://www.ebi.ac.uk/pdbe/entry/emdb/EMD-23018", "description": "EMD-23018"}, {"db": "PDB", "key": "7KSG", "description": "SARS-CoV-2 spike in complex with nanobodies E"}, {"db": "PDB", "key": "7B14", "description": "Nanobody E bound to Spike-RBD in a localized reconstruction."}, {"db": "PDB", "key": "7B11", "description": "SARS-CoV-spike with two RBDs up bound to VHH V on all RBDs"}, {"db": "PDB", "key": "7B18", "description": "SARS-CoV-spike bound to two neutralising nanobodies"}, {"db": "PDB", "key": "7B17", "description": "SARS-CoV-spike RBD bound to two neutralising nanobodies"}], "notes": [], "created": "2021-01-15T13:19:46.751Z", "modified": "2021-02-26T08:47:18.838Z"}, {"entity": "publication", "iuid": "2e3218c29d0d4fcc9d2c729ae25a3dd4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e3218c29d0d4fcc9d2c729ae25a3dd4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e3218c29d0d4fcc9d2c729ae25a3dd4"}}, "title": "Life with Parkinson\u2019s Disease During the COVID-19 Pandemic: The Pressure Is \u201cOFF\u201d", "authors": [{"family": "H\u00d8rmann Thomsen", "given": "Trine", "initials": "T"}, {"family": "Wallerstedt", "given": "Susanna M", "initials": "SM"}, {"family": "Winge", "given": "Kristian", "initials": "K"}, {"family": "Bergquist", "given": "Filip", "initials": "F"}], "type": "journal-article", "published": "2021-01-12", "journal": {"title": "JPD", "issn": "1877-7171", "volume": null, "issue": null, "pages": "1-5", "issn-l": null}, "abstract": "People with Parkinson's disease (PwP) have been suggested to be more vulnerable to negative psychological and psycho-social effects of the COVID-19 pandemic. Our aim was to assess the potential impact of the COVID-19 pandemic in PwP. A Danish/Swedish cohort of 67 PwP was analysed. Health-related quality of life (HRQL), depression, anxiety, apathy, sleep and motor symptom-scores were included in the analysis. Additionally, the Danish participants provided free-text descriptions of life during the pandemic. Overall, the participants reported significantly better HRQL during the COVID-19 period compared with before. Reduced social pressure may be part of the explanation. Despite worsened anxiety, night sleep improved.", "doi": "10.3233/jpd-202342", "pmid": "33459663", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-20T14:56:06.163Z", "modified": "2021-02-26T08:45:47.993Z"}, {"entity": "publication", "iuid": "07fb542a0f25476990091489eaf9e0db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07fb542a0f25476990091489eaf9e0db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07fb542a0f25476990091489eaf9e0db"}}, "title": "High Rates of COVID-19 Vaccine Hesitancy and Its Association with Conspiracy Beliefs: A Study in Jordan and Kuwait among Other Arab Countries", "authors": [{"family": "Sallam", "given": "Malik", "initials": "M"}, {"family": "Dababseh", "given": "Deema", "initials": "D"}, {"family": "Eid", "given": "Huda", "initials": "H"}, {"family": "Al-Mahzoum", "given": "Kholoud", "initials": "K"}, {"family": "Al-Haidar", "given": "Ayat", "initials": "A"}, {"family": "Taim", "given": "Duaa", "initials": "D"}, {"family": "Yaseen", "given": "Alaa", "initials": "A"}, {"family": "Ababneh", "given": "Nidaa A", "initials": "NA"}, {"family": "Bakri", "given": "Faris G", "initials": "FG"}, {"family": "Mahafzah", "given": "Azmi", "initials": "A"}], "type": "journal-article", "published": "2021-01-12", "journal": {"title": "Vaccines", "issn": "2076-393X", "issn-l": null, "volume": "9", "issue": "1", "pages": "42"}, "abstract": null, "doi": "10.3390/vaccines9010042", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-15T13:13:59.416Z", "modified": "2021-06-18T10:01:39.292Z"}, {"entity": "publication", "iuid": "87a9168f79af44dfa5c06f3be54a5e14", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87a9168f79af44dfa5c06f3be54a5e14.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87a9168f79af44dfa5c06f3be54a5e14"}}, "title": "Cytoplasmic short linear motifs in ACE2 and integrin \u03b23 link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy.", "authors": [{"family": "Kliche", "given": "Johanna", "initials": "J", "orcid": "0000-0003-3179-4635", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18ffcca5dbaa45bcad0d1385df5d0c12.json"}}, {"family": "Kuss", "given": "Hanna", "initials": "H", "orcid": "0000-0001-8948-7035", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/395062f1a0fe486cbfc1d025fa60bdad.json"}}, {"family": "Ali", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-8858-6776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0515e4fd072741b0a01456320bbf73de.json"}}, {"family": "Ivarsson", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-7081-3846", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b3cf0504a1b476f906c4b3e22b05d5a.json"}}], "type": "journal article", "published": "2021-01-12", "journal": {"title": "Sci Signal", "issn": "1937-9145", "issn-l": null, "volume": "14", "issue": "665", "pages": null}, "abstract": "The spike protein of SARS-CoV-2 binds the angiotensin-converting enzyme 2 (ACE2) on the host cell surface and subsequently enters host cells through receptor-mediated endocytosis. Additional cell receptors may be directly or indirectly involved, including integrins. The cytoplasmic tails of ACE2 and integrins contain several predicted short linear motifs (SLiMs) that may facilitate internalization of the virus as well as its subsequent propagation through processes such as autophagy. Here, we measured the binding affinity of predicted interactions between SLiMs in the cytoplasmic tails of ACE2 and integrin \u03b23 with proteins that mediate endocytic trafficking and autophagy. We validated that a class I PDZ-binding motif mediated binding of ACE2 to the scaffolding proteins SNX27, NHERF3, and SHANK, and that a binding site for the clathrin adaptor AP2 \u03bc2 in ACE2 overlaps with a phospho-dependent binding site for the SH2 domains of Src family tyrosine kinases. Furthermore, we validated that an LC3-interacting region (LIR) in integrin \u03b23 bound to the ATG8 domains of the autophagy receptors MAP1LC3 and GABARAP in a manner enhanced by LIR-adjacent phosphorylation. Our results provide molecular links between cell receptors and mediators of endocytosis and autophagy that may facilitate viral entry and propagation.", "doi": "10.1126/scisignal.abf1117", "pmid": "33436498", "labels": {"Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7928716"}, {"db": "pii", "key": "14/665/eabf1117"}], "notes": [], "created": "2021-01-08T08:52:49.399Z", "modified": "2023-06-19T15:00:19.344Z"}, {"entity": "publication", "iuid": "7cea9ce7584b467692597202c1fba7d1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7cea9ce7584b467692597202c1fba7d1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7cea9ce7584b467692597202c1fba7d1"}}, "title": "CSF Biomarkers in Patients With COVID-19 and Neurologic Symptoms: A Case Series.", "authors": [{"family": "Ed\u00e9n", "given": "Arvid", "initials": "A"}, {"family": "Kanberg", "given": "Nelly", "initials": "N"}, {"family": "Gostner", "given": "Johanna", "initials": "J", "orcid": "0000-0003-1532-5177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42618c3aa97e473581a66529c2a8b4b2.json"}}, {"family": "Fuchs", "given": "Dietmar", "initials": "D"}, {"family": "Hagberg", "given": "Lars", "initials": "L"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Price", "given": "Richard W", "initials": "RW"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "case reports", "published": "2021-01-12", "journal": {"title": "Neurology", "issn": "1526-632X", "issn-l": "0028-3878", "volume": "96", "issue": "2", "pages": "e294-e300"}, "abstract": "To explore whether hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and neurologic symptoms have evidence of CNS infection, inflammation, and injury using CSF biomarker measurements.\n\nWe assessed CSF SARS-CoV-2 RNA along with CSF biomarkers of intrathecal inflammation (CSF white blood cell count, neopterin, \u03b22-microglobulin, and immunoglobulin G index), blood-brain barrier integrity (albumin ratio), and axonal injury (CSF neurofilament light chain protein [NfL]) in 6 patients with moderate to severe coronavirus disease 2019 (COVID-19) and neurologic symptoms who had undergone a diagnostic lumbar puncture. Neurologic symptoms and signs included features of encephalopathies (4 of 6), suspected meningitis (1 of 6), and dysgeusia (1 of 6). SARS-CoV-2 infection was confirmed by real-time PCR analysis of nasopharyngeal swabs.\n\nSARS-CoV-2 RNA was detected in the plasma of 2 patients (cycle threshold [Ct] value 35.0-37.0) and in CSF at low levels (Ct 37.2, 38.0, 39.0) in 3 patients in 1 but not in a second real-time PCR assay. CSF neopterin (median 43.0 nmol/L) and \u03b22-microglobulin (median 3.1 mg/L) were increased in all. Median immunoglobulin G index (0.39), albumin ratio (5.35), and CSF white blood cell count (<3 cells/\u00b5L) were normal in all, while CSF NfL was elevated in 2 patients.\n\nOur results in patients with COVID-19 and neurologic symptoms suggest an unusual pattern of marked CSF inflammation in which soluble markers were increased but white cell response and other immunologic features typical of CNS viral infections were absent. While our initial hypothesis centered on CNS SARS-CoV-2 invasion, we could not convincingly detect SARS-CoV-2 as the underlying driver of CNS inflammation. These features distinguish COVID-19 CSF from other viral CNS infections and raise fundamental questions about the CNS pathobiology of SARS-CoV-2 infection.", "doi": "10.1212/WNL.0000000000010977", "pmid": "33004602", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "WNL.0000000000010977"}], "notes": [], "created": "2020-10-28T09:06:39.849Z", "modified": "2023-06-19T14:46:31.151Z"}, {"entity": "publication", "iuid": "aaef86b6c7a14c1abe87aa0aef4e82b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aaef86b6c7a14c1abe87aa0aef4e82b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aaef86b6c7a14c1abe87aa0aef4e82b1"}}, "title": "Stimulating the Resolution of Inflammation Through Omega-3 Polyunsaturated Fatty Acids in COVID-19: Rationale for the COVID-Omega-F Trial.", "authors": [{"family": "Arnardottir", "given": "Hildur", "initials": "H"}, {"family": "Pawelzik", "given": "Sven-Christian", "initials": "SC", "orcid": "0000-0001-8704-6607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5249b23453a347a883217f7c90cfeb00.json"}}, {"family": "\u00d6hlund Wistbacka", "given": "Ulf", "initials": "U"}, {"family": "Artiach", "given": "Gonzalo", "initials": "G"}, {"family": "Hofmann", "given": "Robin", "initials": "R"}, {"family": "Reinholdsson", "given": "Ingalill", "initials": "I"}, {"family": "Braunschweig", "given": "Frieder", "initials": "F"}, {"family": "Tornvall", "given": "Per", "initials": "P"}, {"family": "Religa", "given": "Dorota", "initials": "D"}, {"family": "B\u00e4ck", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-01-11", "journal": {"title": "Front Physiol", "issn": "1664-042X", "volume": "11", "issue": null, "pages": "624657", "issn-l": null}, "abstract": "Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). SARS-CoV-2 triggers an immune response with local inflammation in the lung, which may extend to a systemic hyperinflammatory reaction. Excessive inflammation has been reported in severe cases with respiratory failure and cardiovascular complications. In addition to the release of cytokines, referred to as cytokine release syndrome or \"cytokine storm,\" increased pro-inflammatory lipid mediators derived from the omega-6 polyunsaturated fatty acid (PUFA) arachidonic acid may cause an \"eicosanoid storm,\" which contributes to the uncontrolled systemic inflammation. Specialized pro-resolving mediators, which are derived from omega-3 PUFA, limit inflammatory reactions by an active process called resolution of inflammation. Here, the rationale for omega-3 PUFA supplementation in COVID-19 patients is presented along with a brief overview of the study protocol for the trial \"Resolving Inflammatory Storm in COVID-19 Patients by Omega-3 Polyunsaturated Fatty Acids - A single-blind, randomized, placebo-controlled feasibility study\" (COVID-Omega-F). EudraCT: 2020-002293-28; clinicaltrials.gov: NCT04647604.", "doi": "10.3389/fphys.2020.624657", "pmid": "33505321", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC7830247"}, {"db": "ClinicalTrials.gov", "key": "NCT04647604"}], "notes": [], "created": "2021-01-29T15:12:20.798Z", "modified": "2023-06-19T15:19:23.375Z"}, {"entity": "publication", "iuid": "0ab1e98bc6c24f64ad568682517aee4f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ab1e98bc6c24f64ad568682517aee4f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ab1e98bc6c24f64ad568682517aee4f"}}, "title": "Impact on physical and mental health among medical personnel in Wuhan during COVID-19 outbreak: a cluster analysis.", "authors": [{"family": "Gao", "given": "Jing", "initials": "J"}, {"family": "Li", "given": "Jing", "initials": "J"}, {"family": "Han", "given": "Xia", "initials": "X"}, {"family": "Yuan", "given": "Yuan", "initials": "Y"}, {"family": "Li", "given": "Chuan-Xing", "initials": "CX"}, {"family": "Zhang", "given": "Dong-Quan", "initials": "DQ"}], "type": "journal article", "published": "2021-01-11", "journal": {"title": "Int J Med Sci", "issn": "1449-1907", "volume": "18", "issue": "5", "pages": "1185-1188", "issn-l": null}, "abstract": "Background: Increased stress among medical personnel had been reported in previous virus outbreaks. The novel coronavirus disease (COVID-19) emerged in December 2019, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). No qualitative assessment has yet described the physical and mental health conditions of frontline medical personnel in the COVID-19 outbreaks. Methods: Here, 251 frontline medical personnel involved in COVID-19 missions completed electronic questionnaires, consisting of 31 categorical variables related to their physical and mental health status, medical history and environmental conditions. We constructed a correlation amongst these variables through pairwise Kendall rank correlation coefficient test. Then, clusters of highly correlated variables were identified using the leading eigenvector. Finally, we used the network and clusters to clarify the correlations amongst variables. Results: This qualitative study identified the six clusters. Cluster 1 was characterized by skin allergy. Cluster 2 was predominantly associated with anxiety. Cluster 3 consisted mostly of respiratory symptoms. The participants in cluster 4 had medical history. Cluster 5 and cluster 6 were characterized by disinfection and demography, respectively. Finally, we revealed three major findings. First, more than 80% of medical personnel worry about COVID-19-related infection and experience newly appearing anxiety (56.2%), airway or heart symptoms (34.3%) and skin allergies (20.3%). Second, COVID-19-related worry significantly associates with all variables in the anxiety and respiratory symptom clusters. Third, new-onset skin allergies did not associate with either disinfection or anxiety, but did associate with a previous history of allergies. Conclusions: COVID-19-related worry leads to physical and mental health problems amongst medical personnel. Effective responses and interventions could relieve a series of new-onset physical and mental health problems.", "doi": "10.7150/ijms.51315", "pmid": "33526979", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijmsv18p1185"}, {"db": "pmc", "key": "PMC7847622"}], "notes": [], "created": "2021-02-04T18:21:47.061Z", "modified": "2021-02-26T08:46:59.832Z"}, {"entity": "publication", "iuid": "040cdb5e913f4417ba0f2d8f35bfc266", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/040cdb5e913f4417ba0f2d8f35bfc266.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/040cdb5e913f4417ba0f2d8f35bfc266"}}, "title": "Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection.", "authors": [{"family": "Monteil", "given": "Vanessa", "initials": "V", "orcid": "0000-0002-2652-5695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8ba8a0b1af6423b9cba0fc4bb3177cd.json"}}, {"family": "Dyczynski", "given": "Matheus", "initials": "M", "orcid": "0000-0002-7650-3574", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/85f093ab4ac24580810b0ea22f1dd0c6.json"}}, {"family": "Lauschke", "given": "Volker M", "initials": "VM", "orcid": "0000-0002-1140-6204", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe2e21e55733492996018d1a5b037969.json"}}, {"family": "Kwon", "given": "Hyesoo", "initials": "H"}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G"}, {"family": "Youhanna", "given": "Sonia", "initials": "S", "orcid": "0000-0002-9376-8478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b777b2409fb34cd0b0d154bf2aab5d5d.json"}}, {"family": "Zhang", "given": "Haibo", "initials": "H", "orcid": "0000-0002-1714-3038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1fe0f99f8a74a87a4772166d46744de.json"}}, {"family": "Slutsky", "given": "Arthur S", "initials": "AS", "orcid": "0000-0002-6063-3876", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f9a9cd065c74b71960c62e55caf6b58.json"}}, {"family": "Hurtado Del Pozo", "given": "Carmen", "initials": "C"}, {"family": "Horn", "given": "Moritz", "initials": "M", "orcid": "0000-0002-5324-7256", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a000f2fad24410281396504ca78b6d8.json"}}, {"family": "Montserrat", "given": "Nuria", "initials": "N", "orcid": "0000-0002-1603-1755", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d4cdae2b5b34dd798f73faa0a3aa391.json"}}, {"family": "Penninger", "given": "Josef M", "initials": "JM", "orcid": "0000-0002-8194-3777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e56aaa008524272bf252df804e06991.json"}}, {"family": "Mirazimi", "given": "Ali", "initials": "A", "orcid": "0000-0003-2371-6055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0651be47429c4e5880a13b839d04fe1d.json"}}], "type": "journal article", "published": "2021-01-11", "journal": {"title": "EMBO Mol Med", "issn": "1757-4684", "issn-l": "1757-4676", "volume": "13", "issue": "1", "pages": "e13426"}, "abstract": "There is a critical need for safe and effective drugs for COVID-19. Only remdesivir has received authorization for COVID-19 and has been shown to improve outcomes but not decrease mortality. However, the dose of remdesivir is limited by hepatic and kidney toxicity. ACE2 is the critical cell surface receptor for SARS-CoV-2. Here, we investigated additive effect of combination therapy using remdesivir with recombinant soluble ACE2 (high/low dose) on Vero E6 and kidney organoids, targeting two different modalities of SARS-CoV-2 life cycle: cell entry via its receptor ACE2 and intracellular viral RNA replication. This combination treatment markedly improved their therapeutic windows against SARS-CoV-2 in both models. By using single amino-acid resolution screening in haploid ES cells, we report a singular critical pathway required for remdesivir toxicity, namely, Adenylate Kinase 2. The data provided here demonstrate that combining two therapeutic modalities with different targets, common strategy in HIV treatment, exhibit strong additive effects at sub-toxic concentrations. Our data lay the groundwork for the study of combinatorial regimens in future COVID-19 clinical trials.", "doi": "10.15252/emmm.202013426", "pmid": "33179852", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: H2020": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC7799356"}], "notes": [], "created": "2020-11-19T19:45:22.452Z", "modified": "2023-06-19T14:43:00.181Z"}, {"entity": "publication", "iuid": "bc16a7b8aa2048cbbe80b22f956dbe5f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bc16a7b8aa2048cbbe80b22f956dbe5f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bc16a7b8aa2048cbbe80b22f956dbe5f"}}, "title": "[Temporal variations in excess mortality during phase 1 and phase 2 of the COVID-19 epidemic in Italy].", "authors": [{"family": "Michelozzi", "given": "Paola", "initials": "P"}, {"family": "De' Donato", "given": "Francesca", "initials": "F"}, {"family": "De Sario", "given": "Manuela", "initials": "M"}, {"family": "Stortichini", "given": "Matteo", "initials": "M"}, {"family": "Stafoggia", "given": "Massimo", "initials": "M"}, {"family": "Niccioli", "given": "Fiammetta", "initials": "F"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Boros", "given": "Stefano", "initials": "S"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Urdiales", "given": "Alberto Mateo", "initials": "AM"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Rossi", "given": "Pasqualino", "initials": "P"}, {"family": "Rezza", "given": "Giovanni", "initials": "G"}, {"family": "Costa", "given": "Giuseppe", "initials": "G"}, {"family": "Davoli", "given": "Marina", "initials": "M"}], "type": "journal article", "published": "2021-01-09", "journal": {"title": "Epidemiol Prev", "issn": "1120-9763", "issn-l": null, "volume": "44", "issue": "5-6 Suppl 2", "pages": "236-243"}, "abstract": "to assess the temporal variation in excess total mortality and the portion of excess explained by COVID-19 deaths by geographical area, gender, and age during the COVID-19 epidemic.\r\n\r\ndescriptive analysis of temporal variations of total excess deaths and COVID-19 deaths in the phase 1 and phase 2 of the epidemic in Italy.\r\n\r\n12 Northern cities and 20 Central-Southern cities from December 2019 to June 2020: daily mortality from the National Surveillance System of Daily Mortality (SiSMG) and COVID-19 deaths from the integrated COVID-19 surveillance system.\r\n\r\ntotal mortality excess and COVID-19 deaths, defined as deaths in microbiologically confirmed cases of SARS-CoV-2, by gender and age groups.\r\n\r\nthe largest excess mortality was observed in the North and during the first phase of the epidemic. The portion of excess mortality explained by COVID-19 decreases with age, decreasing to 51% among the very old (>=85 years). In phase 2 (until June 2020), the impact was more contained and totally attributable to COVID-19 deaths and this suggests an effectiveness of social distancing measures.\r\n\r\nmortality surveillance is a sensible information basis for the monitoring of health impact of the different phases of the epidemic and supporting decision making at the local and national level on containment measures to put in place in coming months.", "doi": "10.19191/EP20.5-6.S2.123", "pmid": "33412815", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "5208"}], "notes": [], "created": "2021-01-22T09:21:41.132Z", "modified": "2021-02-26T08:47:00.183Z"}, {"entity": "publication", "iuid": "67723ab246aa40aeb3fb9fa0f012aa56", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/67723ab246aa40aeb3fb9fa0f012aa56.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/67723ab246aa40aeb3fb9fa0f012aa56"}}, "title": "[Integrated Surveillance in Italy: outputs and related activities].", "authors": [{"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Urdiales", "given": "Alberto Mateo", "initials": "AM"}, {"family": "Vescio", "given": "Maria Fenicia", "initials": "MF"}, {"family": "Rota", "given": "Maria Cristina", "initials": "MC"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Boros", "given": "Stefano", "initials": "S"}, {"family": "Bellino", "given": "Stefania", "initials": "S"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Ciervo", "given": "Alessandra", "initials": "A"}, {"family": "Punzo", "given": "Ornella", "initials": "O"}, {"family": "Filia", "given": "Antonietta", "initials": "A"}, {"family": "Tallon", "given": "Marco", "initials": "M"}, {"family": "Di Benedetto", "given": "Corrado", "initials": "C"}, {"family": "Spuri", "given": "Matteo", "initials": "M"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Bella", "given": "Antonella", "initials": "A"}, {"family": "Gruppo Referenti regionali della Sorveglianza Integrata COVID-19", "given": "", "initials": ""}], "type": "journal article", "published": "2021-01-09", "journal": {"title": "Epidemiol Prev", "issn": "1120-9763", "volume": "44", "issue": "5-6 Suppl 2", "pages": "70-80", "issn-l": null}, "abstract": "to describe the integrated surveillance system of COVID-19 in Italy, to illustrate the outputs used to return epidemiological information on the spread of the epidemic to the competent public health bodies and to the Italian population, and to describe how the surveillance data contributes to the ongoing weekly regional monitoring and risk assessment system.\n\nthe COVID-19 integrated surveillance system is the result of a close and continuous collaboration between the Italian National Institute of Health (ISS), the Italian Ministry of Health, and the regional and local health authorities. Through a web platform, it collects individual data of laboratory confirmed cases of SARS-CoV-2 infection and gathers information on their residence, laboratory diagnosis, hospitalisation, clinical status, risk factors, and outcome. Results, for different levels of aggregation and risk categories, are published daily and weekly on the ISS website, and made available to national and regional public health authorities; these results contribute one of the information sources of the regional monitoring and risk assessment system.\n\nthe COVID-19 integrated surveillance system monitors the space-time distribution of cases and their characteristics. Indicators used in the weekly regional monitoring and risk assessment system include process indicators on completeness and results indicators on weekly trends of newly diagnosed cases per Region.\n\nthe outputs of the integrated surveillance system for COVID-19 provide timely information to health authorities and to the general population on the evolution of the epidemic in Italy. They also contribute to the continuous re-assessment of risk related to transmission and impact of the epidemic thus contributing to the management of COVID-19 in Italy.", "doi": "10.19191/EP20.5-6.S2.105", "pmid": "33412796", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "5088"}], "notes": [], "created": "2021-01-22T09:22:48.456Z", "modified": "2021-02-26T08:47:00.008Z"}, {"entity": "publication", "iuid": "c8b44880a5bf4cc19fcf261c46c33ab8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c8b44880a5bf4cc19fcf261c46c33ab8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c8b44880a5bf4cc19fcf261c46c33ab8"}}, "title": "Rituximab for the treatment of multiple sclerosis: a review.", "authors": [{"family": "Chisari", "given": "Clara Grazia", "initials": "CG"}, {"family": "Sgarlata", "given": "Eleonora", "initials": "E"}, {"family": "Arena", "given": "Sebastiano", "initials": "S"}, {"family": "Toscano", "given": "Simona", "initials": "S"}, {"family": "Luca", "given": "Maria", "initials": "M"}, {"family": "Patti", "given": "Francesco", "initials": "F"}], "type": "journal article", "published": "2021-01-08", "journal": {"title": "J Neurol", "issn": "1432-1459", "volume": null, "issue": null, "issn-l": null}, "abstract": "In the last decades, evidence suggesting the direct or indirect involvement of B cells on multiple sclerosis (MS) pathogenesis has accumulated. The increased amount of data on the efficacy and safety of B-cell-depleting therapies from several studies has suggested the addition of these drugs as treatment options to the current armamentarium of disease modifying therapies (DMTs) for MS. Particularly, rituximab (RTX), a chimeric monoclonal antibody directed at CD20 positive B lymphocytes resulting in cell-mediated apoptosis, has been demonstrated to reduce inflammatory activity, incidence of relapses and new brain lesions on magnetic resonance imaging (MRI) in patients with relapsing-remitting MS (RRMS). Additional evidence also demonstrated that patients with progressive MS (PMS) may benefit from RTX, which also showed to be well tolerated, with acceptable safety risks and favorable cost-effectiveness profile.Despite these encouraging results, RTX is currently approved for non-Hodgkin's lymphoma, chronic lymphocytic leukemia, several forms of vasculitis and rheumatoid arthritis, while it can only be administered off-label for MS treatment. Between Northern European countries exist different rules for using not licensed drug for treating MS. The Sweden MS register reports a high rate (53.5%) of off-label RTX prescriptions in relation to other annually started DMTs to treat MS patients, while Danish and Norwegian neurologists have to use other anti-CD20 drugs, as ocrelizumab, in most of the cases.In this paper, we review the pharmacokinetics, pharmacodynamics, clinical efficacy, safety profile and cost effectiveness aspects of RTX for the treatment of MS. Particularly, with the approval of new anti-CD20 DMTs, the recent worldwide COVID-19 emergency and the possible increased risk of infection with this class of drugs, this review sheds light on the use of RTX as an alternative treatment option for MS management, while commenting the gaps of knowledge regarding this drug.", "doi": "10.1007/s00415-020-10362-z", "pmid": "33416999", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00415-020-10362-z"}], "notes": [], "created": "2021-01-10T18:21:47.460Z", "modified": "2021-01-10T18:21:47.469Z"}, {"entity": "publication", "iuid": "4977214db52547d5837a73d23539ceee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4977214db52547d5837a73d23539ceee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4977214db52547d5837a73d23539ceee"}}, "title": "Mental Distress and Human Rights Violations During COVID-19: A Rapid Review of the Evidence Informing Rights, Mental Health Needs, and Public Policy Around Vulnerable Populations.", "authors": [{"family": "Rahman", "given": "Muhammad", "initials": "M"}, {"family": "Ahmed", "given": "Rabab", "initials": "R"}, {"family": "Moitra", "given": "Modhurima", "initials": "M"}, {"family": "Damschroder", "given": "Laura", "initials": "L"}, {"family": "Brownson", "given": "Ross", "initials": "R"}, {"family": "Chorpita", "given": "Bruce", "initials": "B"}, {"family": "Idele", "given": "Priscilla", "initials": "P"}, {"family": "Gohar", "given": "Fatima", "initials": "F"}, {"family": "Huang", "given": "Keng Yen", "initials": "KY"}, {"family": "Saxena", "given": "Shekhar", "initials": "S"}, {"family": "Lai", "given": "Joanna", "initials": "J"}, {"family": "Peterson", "given": "Stefan Swartling", "initials": "SS"}, {"family": "Harper", "given": "Gary", "initials": "G"}, {"family": "McKay", "given": "Mary", "initials": "M"}, {"family": "Amugune", "given": "Beatrice", "initials": "B"}, {"family": "Esho", "given": "Tammary", "initials": "T"}, {"family": "Ronen", "given": "Keshet", "initials": "K"}, {"family": "Othieno", "given": "Caleb", "initials": "C"}, {"family": "Kumar", "given": "Manasi", "initials": "M"}], "type": "journal article", "published": "2021-01-08", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "11", "issue": null, "pages": "603875", "issn-l": "1664-0640"}, "abstract": "Background: COVID-19 prevention and mitigation efforts were abrupt and challenging for most countries with the protracted lockdown straining socioeconomic activities. Marginalized groups and individuals are particularly vulnerable to adverse effects of the pandemic such as human rights abuses and violations which can lead to psychological distress. In this review, we focus on mental distress and disturbances that have emanated due to human rights restrictions and violations amidst the pandemic. We underscore how mental health is both directly impacted by the force of pandemic and by prevention and mitigation structures put in place to combat the disease. Methods: We conducted a review of relevant studies examining human rights violations in COVID-19 response, with a focus on vulnerable populations, and its association with mental health and psychological well-being. We searched PubMed and Embase databases for studies between December 2019 to July 2020. Three reviewers evaluated the eligibility criteria and extracted data. Results: Twenty-four studies were included in the systematic inquiry reporting on distress due to human rights violations. Unanimously, the studies found vulnerable populations to be at a high risk for mental distress. Limited mobility rights disproportionately harmed psychiatric patients, low-income individuals, and minorities who were at higher risk for self-harm and worsening mental health. Healthcare workers suffered negative mental health consequences due to stigma and lack of personal protective equipment and stigma. Other vulnerable groups such as the elderly, children, and refugees also experienced negative consequences. Conclusions: This review emphasizes the need to uphold human rights and address long term mental health needs of populations that have suffered disproportionately during the pandemic. Countries can embed a proactive psychosocial response to medical management as well as in existing prevention strategies. International human rights guidelines are useful in this direction but an emphasis should be placed on strengthening rights informed psychosocial response with specific strategies to enhance mental health in the long-term. We underscore that various fundamental human rights are interdependent and therefore undermining one leads to a poor impact on the others. We strongly recommend global efforts toward focusing both on minimizing fatalities, protecting human rights, and promoting long term mental well-being.", "doi": "10.3389/fpsyt.2020.603875", "pmid": "33488426", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7820171"}], "notes": [], "created": "2021-02-04T18:39:24.005Z", "modified": "2021-02-04T18:39:33.273Z"}, {"entity": "publication", "iuid": "c0aa971aae314be58621c5bea009cf62", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c0aa971aae314be58621c5bea009cf62.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c0aa971aae314be58621c5bea009cf62"}}, "title": "Inherent random fluctuations in COVID-19 outbreaks may explain rapid growth of new mutated virus variants", "authors": [{"family": "Bodin", "given": "Kenneth", "initials": "K"}, {"family": "Rocklov", "given": "Joacim", "initials": "J"}], "type": "posted-content", "published": "2021-01-08", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.01.07.21249353", "pmid": null, "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-10T18:36:49.125Z", "modified": "2021-02-26T08:45:48.640Z"}, {"entity": "publication", "iuid": "e3bd61a03fcf42a7871602b18648b374", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3bd61a03fcf42a7871602b18648b374.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3bd61a03fcf42a7871602b18648b374"}}, "title": "Epidemiological characteristics of COVID-19 cases in non-Italian nationals notified to the Italian surveillance system.", "authors": [{"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Bellino", "given": "Stefania", "initials": "S"}, {"family": "Rota", "given": "Maria C", "initials": "MC"}, {"family": "Boros", "given": "Stefano", "initials": "S"}, {"family": "Vescio", "given": "Maria F", "initials": "MF"}, {"family": "D'Ancona", "given": "Fortunato P", "initials": "FP"}, {"family": "Siddu", "given": "Andrea", "initials": "A"}, {"family": "Punzo", "given": "Ornella", "initials": "O"}, {"family": "Filia", "given": "Antonietta", "initials": "A"}, {"family": "Brusaferro", "given": "Silvio", "initials": "S"}, {"family": "Rezza", "given": "Giovanni", "initials": "G"}, {"family": "Dente", "given": "Maria G", "initials": "MG"}, {"family": "Declich", "given": "Silvia", "initials": "S"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "group", "given": "COVID-19 working", "initials": "Cw"}, {"family": ",", "given": "", "initials": ""}], "type": "journal article", "published": "2021-01-08", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": null, "issue": null, "pages": null}, "abstract": "International literature suggests that disadvantaged groups are at higher risk of morbidity and mortality from SARS-CoV-2 infection due to poorer living/working conditions and barriers to healthcare access. Yet, to date, there is no evidence of this disproportionate impact on non-national individuals, including economic migrants, short-term travellers, and refugees.\r\n\r\nWe analysed data from the Italian surveillance system of all COVID-19 laboratory-confirmed cases tested positive from the beginning of the outbreak (20th of February) to the 19th of July 2020. We used multilevel negative-binomial regression models to compare the case-fatality and the rate of admission to hospital and intensive care unit (ICU) between Italian and non-Italian nationals. The analysis was adjusted for differences in demographic characteristics, pre-existing comorbidities, and period of diagnosis.\r\n\r\nWe analysed 213,180 COVID-19 cases, including 15,974 (7.5%) non-Italian nationals. We found that, compared to Italian cases, non-Italian cases were diagnosed at a later date and were more likely to be hospitalised [(adjusted rate ratio (ARR)=1.39, 95% confidence interval (CI): 1.33-1.44)] and admitted to ICU (ARR = 1.19, 95% CI: 1.07-1.32), with differences being more pronounced in those coming from countries with lower HDI. We also observed an increased risk of death in non-Italian cases from low-HDI countries (ARR = 1.32, 95% CI: 1.01-1.75).\r\n\r\nA delayed diagnosis in non-Italian cases could explain their worse outcomes compared to Italian cases. Ensuring early access to diagnosis and treatment to non-Italians could facilitate the control of SARS-CoV-2 transmission and improve health outcomes in all people living in Italy, regardless of nationality.", "doi": "10.1093/eurpub/ckaa249", "pmid": "33416859", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6070147"}], "notes": [], "created": "2021-01-10T18:22:12.486Z", "modified": "2021-06-18T09:27:00.582Z"}, {"entity": "publication", "iuid": "f788045b36924a1fbc1785be50402e62", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f788045b36924a1fbc1785be50402e62.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f788045b36924a1fbc1785be50402e62"}}, "title": "Competing Health Risks Associated with the COVID-19 Pandemic and Response: A Scoping Review", "authors": [{"family": "Baral", "given": "Stefan", "initials": "S"}, {"family": "Rao", "given": "Amrita", "initials": "A"}, {"family": "Twahirwa Rwema", "given": "Jean Olivier", "initials": "JO"}, {"family": "Lyons", "given": "Carrie", "initials": "C"}, {"family": "Cevik", "given": "Muge", "initials": "M"}, {"family": "K\u00e5gesten", "given": "Anna E", "initials": "AE"}, {"family": "Diouf", "given": "Daouda", "initials": "D"}, {"family": "Sohn", "given": "Annette H", "initials": "AH"}, {"family": "Phaswana-Mafuya", "given": "Refilwe", "initials": "R"}, {"family": "Kamarulzaman", "given": "Adeeba", "initials": "A"}, {"family": "Millett", "given": "Gregorio", "initials": "G"}, {"family": "Marcus", "given": "Julia L", "initials": "JL"}, {"family": "Mishra", "given": "Sharmistha", "initials": "S"}], "type": "posted-content", "published": "2021-01-08", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.01.07.21249419", "pmid": null, "labels": {"Type: Review": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-01-29T17:36:34.092Z", "modified": "2021-06-09T19:28:34.774Z"}, {"entity": "publication", "iuid": "02eaf5bdae9e4092b8b24cd7533ece27", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02eaf5bdae9e4092b8b24cd7533ece27.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02eaf5bdae9e4092b8b24cd7533ece27"}}, "title": "COVID-19 epidemic in Libya.", "authors": [{"family": "Bredan", "given": "Amin", "initials": "A"}, {"family": "Bakoush", "given": "Omran", "initials": "O"}], "type": "journal article", "published": "2021-01-08", "journal": {"title": "Libyan J Med", "issn": "1819-6357", "issn-l": null, "volume": "16", "issue": "1", "pages": "1871798"}, "abstract": "The first case of COVID-19 was identified in Libya on 24/3/2020, and about 2 months later, the number of reported COVID-19 cases started to increase notably. The outbreak was first prominent in the southern region (Sabha) and then spread to the western and eastern parts of Libya. By 24/12/2020, the reported total number of deaths from COVID-19 reached 1415. There seems to be no published data on the size of the epidemic in Libya. Here, we estimated the number of Libyans exposed to COVID-19 by using a COVID-19 mortality adjusted mathematical model for the spread of infectious diseases. We estimated that 14-20% of the Libyan population have been exposed to the COVID-19 pandemic. Thus, the risk of spread of COVID-19 infections during the coming months is high, and a considerable number of Libyans, particularly the elderly and people with chronic diseases, should be protected against COVID-19 infection. This is particularly urgent in the light of unofficial reports that the relevant healthcare facilities are under extreme stress.", "doi": "10.1080/19932820.2021.1871798", "pmid": "33407008", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-07T17:09:02.169Z", "modified": "2021-06-18T09:54:28.522Z"}, {"entity": "publication", "iuid": "5ef2c75ecf0643128f220f1ae1ce1bdf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5ef2c75ecf0643128f220f1ae1ce1bdf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5ef2c75ecf0643128f220f1ae1ce1bdf"}}, "title": "Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma", "authors": [{"family": "Kermani", "given": "Nazanin Zounemat", "initials": "NZ"}, {"family": "None", "given": "", "initials": ""}, {"family": "Song", "given": "Woo Jung", "initials": "WJ"}, {"family": "Badi", "given": "Yusef", "initials": "Y"}, {"family": "Versi", "given": "Ali", "initials": "A"}, {"family": "Guo", "given": "Yike", "initials": "Y"}, {"family": "Sun", "given": "Kai", "initials": "K"}, {"family": "Bhavsar", "given": "Pank", "initials": "P"}, {"family": "Howarth", "given": "Peter", "initials": "P"}, {"family": "Dahlen", "given": "Sven Erik", "initials": "SE"}, {"family": "Sterk", "given": "Peter J", "initials": "PJ"}, {"family": "Djukanovic", "given": "Ratko", "initials": "R"}, {"family": "Adcock", "given": "Ian M", "initials": "IM"}, {"family": "Chung", "given": "Kian Fan", "initials": "KF"}], "type": "journal-article", "published": "2021-01-07", "journal": {"title": "Respir Res", "issn": "1465-993X", "issn-l": "1465-9921", "volume": "22", "issue": "1", "pages": "101876"}, "abstract": "Bats are reservoirs for a large number of viruses which have potential to cause major human disease outbreaks, including the current coronavirus disease 2019 (COVID-19) pandemic. Major efforts are underway to understand bat immune response to viruses, whereas much less is known about their immune responses to bacteria. In this study, MR1-restricted T (MR1T) cells were detected through the use of MR1 tetramers in circulation and tissues of Pteropus alecto (Pa) bats. Pa MR1T cells exhibited weak responses to MR1-presented microbial metabolites at resting state. However, following priming with MR1-presented agonist they proliferated, upregulated critical transcription factors and cytolytic proteins, and gained transient expression of Th1/17-related cytokines and antibacterial cytotoxicity. Collectively, these findings show that the Pa bat immune system encompasses an abundant and functionally conserved population of MR1T cells with mucosal-associated invariant T-like characteristics, suggesting that MR1 and MR1T cells also play a significant role in bat immune defense.", "doi": "10.1186/s12931-020-01605-8", "pmid": "33344919", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-10T18:25:02.052Z", "modified": "2021-02-26T08:45:48.250Z"}, {"entity": "publication", "iuid": "fd17970ab9a34ca4a39b8a169f6a9f15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fd17970ab9a34ca4a39b8a169f6a9f15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fd17970ab9a34ca4a39b8a169f6a9f15"}}, "title": "Parental experiences of homeschooling during the COVID-19 pandemic: differences between seven European countries and between children with and without mental health conditions", "authors": [{"family": "Thorell", "given": "Lisa B", "initials": "LB"}, {"family": "Skoglund", "given": "Charlotte", "initials": "C"}, {"family": "de la Pe\u00f1a", "given": "Almudena Gim\u00e9nez", "initials": "AG"}, {"family": "Baeyens", "given": "Dieter", "initials": "D"}, {"family": "Fuermaier", "given": "Anselm B M", "initials": "ABM"}, {"family": "Groom", "given": "Madeleine J", "initials": "MJ"}, {"family": "Mammarella", "given": "Irene C", "initials": "IC"}, {"family": "van der Oord", "given": "Saskia", "initials": "S"}, {"family": "van den Hoofdakker", "given": "Barbara J", "initials": "BJ"}, {"family": "Luman", "given": "Marjolein", "initials": "M"}, {"family": "de Miranda", "given": "D\u00e9bora Marques", "initials": "DM"}, {"family": "Siu", "given": "Angela F Y", "initials": "AFY"}, {"family": "Steinmayr", "given": "Ricarda", "initials": "R"}, {"family": "Idrees", "given": "Iman", "initials": "I"}, {"family": "Soares", "given": "Lorrayne Stephane", "initials": "LS"}, {"family": "S\u00f6rlin", "given": "Matilda", "initials": "M"}, {"family": "Luque", "given": "Juan Luis", "initials": "JL"}, {"family": "Moscardino", "given": "Ughetta M", "initials": "UM"}, {"family": "Roch", "given": "Maja", "initials": "M"}, {"family": "Crisci", "given": "Giulia", "initials": "G"}, {"family": "Christiansen", "given": "Hanna", "initials": "H"}], "type": "journal-article", "published": "2021-01-07", "journal": {"title": "Eur Child Adolesc Psychiatry", "issn": "1018-8827", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1007/s00787-020-01706-1", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-10T18:23:30.328Z", "modified": "2021-06-18T09:16:00.365Z"}, {"entity": "publication", "iuid": "d6033efeda044768b62aab15cc8406a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d6033efeda044768b62aab15cc8406a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d6033efeda044768b62aab15cc8406a0"}}, "title": "Minimal transmission of SARS-CoV-2 from paediatric COVID-19 cases in primary schools, Norway, August to November 2020", "authors": [{"family": "Brandal", "given": "Lin T", "initials": "LT"}, {"family": "Ofitserova", "given": "Trine S", "initials": "TS"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}, {"family": "Rykkvin", "given": "Rikard", "initials": "R"}, {"family": "Lund", "given": "Hilde M", "initials": "HM"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "Greve-Isdahl", "given": "Margrethe", "initials": "M"}, {"family": "Bragstad", "given": "Karoline", "initials": "K"}, {"family": "Nyg\u00e5rd", "given": "Karin", "initials": "K"}, {"family": "Winje", "given": "Brita A", "initials": "BA"}], "type": "journal-article", "published": "2021-01-07", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "1", "pages": null}, "abstract": null, "doi": "10.2807/1560-7917.es.2020.26.1.2002011", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "NA", "key": "Available in paper; Detection of SARS-CoV-2 in saliva samples from paediatric COVID-19 index cases and their school contacts", "description": null}], "notes": [], "created": "2021-01-10T18:24:13.864Z", "modified": "2021-06-18T09:43:42.157Z"}, {"entity": "publication", "iuid": "517a97de636c40abaceadf785b375e76", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/517a97de636c40abaceadf785b375e76.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/517a97de636c40abaceadf785b375e76"}}, "title": "Covid-19 FAQ's in Paediatric and Congenital Cardiology - AEPC position paper.", "authors": [{"family": "Sendzikaite", "given": "Skaiste", "initials": "S"}, {"family": "Heying", "given": "Ruth", "initials": "R"}, {"family": "Milanesi", "given": "Ornella", "initials": "O"}, {"family": "Hanseus", "given": "Katarina", "initials": "K"}, {"family": "Michel-Behnke", "given": "Ina", "initials": "I"}], "type": "journal article", "published": "2021-01-07", "journal": {"title": "Cardiol Young", "issn": "1467-1107", "volume": null, "issue": null, "pages": "1-21", "issn-l": null}, "abstract": "The Covid-19 pandemic has had a huge influence in almost all areas of life, affecting societies, economics and health care systems worldwide. The paediatric cardiology community is no exception. As the challenging battle with Covid-19 continues, professionals from the Association for the European Paediatric and Congenital Cardiology (AEPC) receive many questions regarding Covid-19 in a Paediatric and Congenital Cardiology setting. The aim of this paper is to present the AEPC position on frequently asked questions based on the most recent scientific data, as well as to frame a discussion on how to take care of our patients during this unprecedented crisis. As the times are changing quickly and information regarding Covid-19 is very dynamic, continuous collection of evidence will help guide constructive decision-making.", "doi": "10.1017/S1047951120005028", "pmid": "33407975", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1047951120005028"}], "notes": [], "created": "2021-01-07T17:07:20.941Z", "modified": "2021-01-10T18:28:15.315Z"}, {"entity": "publication", "iuid": "c7e1e3e4c7c44e44bc461e8198ec1610", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7e1e3e4c7c44e44bc461e8198ec1610.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7e1e3e4c7c44e44bc461e8198ec1610"}}, "title": "Prehospital identification of Covid-19: an observational study.", "authors": [{"family": "Spangler", "given": "Douglas", "initials": "D"}, {"family": "Blomberg", "given": "Hans", "initials": "H"}, {"family": "Smekal", "given": "David", "initials": "D"}], "type": "journal article", "published": "2021-01-06", "journal": {"title": "Scand J Trauma Resusc Emerg Med", "issn": "1757-7241", "volume": "29", "issue": "1", "pages": "3", "issn-l": "1757-7241"}, "abstract": "The novel coronavirus disease 2019 (Covid-19) pandemic has affected prehospital care systems across the world, but the prehospital presentation of affected patients and the extent to which prehospital care providers are able to identify them is not well characterized. In this study, we describe the presentation of Covid-19 patients in a Swedish prehospital care system, and asses the predictive value of Covid-19 suspicion as documented by dispatch and ambulance nurses.\n\nData for all patients with dispatch, ambulance, and hospital records between January 1-August 31, 2020 were extracted. A descriptive statistical analysis of patients with and without hospital-confirmed Covid-19 was performed. In a subset of records beginning from April 14, we assessed the sensitivity and specificity of documented Covid-19 suspicion in dispatch and ambulance patient care records.\n\nA total of 11,894 prehospital records were included, of which 481 had a primary hospital diagnosis code related to-, or positive test results for Covid-19. Covid-19-positive patients had considerably worse outcomes than patients with negative test results, with 30-day mortality rates of 24% vs 11%, but lower levels of prehospital acuity (e.g. emergent transport rates of 14% vs 22%). About half (46%) of Covid-19-positive patients presented to dispatchers with primary complaints typically associated with Covid-19. Six thousand seven hundred seventy-six records were included in the assessment of predictive value. Sensitivity was 76% (95% CI 71-80) and 82% (78-86) for dispatch and ambulance suspicion respectively, while specificities were 86% (85-87) and 78% (77-79).\n\nWhile prehospital suspicion was strongly indicative of hospital-confirmed Covid-19, based on the sensitivity identified in this study, prehospital suspicion should not be relied upon as a single factor to rule out the need for isolation precautions. The data provided may be used to develop improved guidelines for identifying Covid-19 patients in the prehospital setting.", "doi": "10.1186/s13049-020-00826-6", "pmid": "33407750", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-07T17:08:24.708Z", "modified": "2021-02-26T08:45:48.690Z"}, {"entity": "publication", "iuid": "9743266e3b1c4018b98b4ba412d671cd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9743266e3b1c4018b98b4ba412d671cd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9743266e3b1c4018b98b4ba412d671cd"}}, "title": "Biosocial Strategies to Address the Socioeconomic Determinants and Consequences of the TB and COVID-19 Pandemics.", "authors": [{"family": "Pedrazzoli", "given": "Debora", "initials": "D"}, {"family": "Wingfield", "given": "Tom", "initials": "T"}], "type": "journal article", "published": "2021-01-06", "journal": {"title": "Am J Trop Med Hyg", "issn": "1476-1645", "issn-l": "0002-9637", "volume": null, "issue": null, "pages": null}, "abstract": "Biosocial Strategies to Address the Socioeconomic Determinants and Consequences of the TB and COVID-19 Syndemics.", "doi": "10.4269/ajtmh.20-1641", "pmid": "33410391", "labels": {"Type: Other": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-08T07:18:14.824Z", "modified": "2021-06-18T09:11:25.810Z"}, {"entity": "publication", "iuid": "7d7c1595811b45f09fec445a255d13db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d7c1595811b45f09fec445a255d13db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d7c1595811b45f09fec445a255d13db"}}, "title": "The challenges of COVID-19 testing in Africa: the Ethiopian experience.", "authors": [{"family": "Mulu", "given": "Andargachew", "initials": "A"}, {"family": "Bekele", "given": "Amsalu", "initials": "A"}, {"family": "Abdissa", "given": "Alemseged", "initials": "A"}, {"family": "Balcha", "given": "Taye Tolera", "initials": "TT"}, {"family": "Habtamu", "given": "Meseret", "initials": "M"}, {"family": "Mihret", "given": "Adane", "initials": "A"}, {"family": "Alemayehu", "given": "Dawit Hailu", "initials": "DH"}, {"family": "Beyene", "given": "Getachew Tesfaye", "initials": "GT"}, {"family": "Bayih", "given": "Abebe Genetu", "initials": "AG"}], "type": "journal article", "published": "2021-01-05", "journal": {"title": "Pan Afr Med J", "issn": "1937-8688", "issn-l": null, "volume": "38", "issue": null, "pages": "6"}, "abstract": "Novel coronavirus disease (COVID-19) is spreading rapidly and creating a huge economic, social and public health challenge worldwide. Although currently an effective vaccine is ready, its distribution is limited, and hence the only currently available lever to reduce transmission is to identify and isolate individuals who are contagious. Thus, testing for SARS CoV-2 has a paramount importance. However, testing in many African countries including Ethiopia has multidimensional growing challenges. Here, we tried to identify, categorize and summarize the challenges of COVID-19 testing in Africa from Ethiopian experience.", "doi": "10.11604/pamj.2021.38.6.26902", "pmid": "33520075", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PAMJ-38-6"}, {"db": "pmc", "key": "PMC7825374"}], "notes": [], "created": "2021-02-04T18:37:05.674Z", "modified": "2021-06-18T08:50:19.957Z"}, {"entity": "publication", "iuid": "7de895fcacdf46a48f1977a21c2c05d1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7de895fcacdf46a48f1977a21c2c05d1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7de895fcacdf46a48f1977a21c2c05d1"}}, "title": "Recovery scenario and immunity in COVID-19 disease: A new strategy to predict the potential of reinfection.", "authors": [{"family": "Khoshkam", "given": "Zahra", "initials": "Z"}, {"family": "Aftabi", "given": "Younes", "initials": "Y"}, {"family": "Stenvinkel", "given": "Peter", "initials": "P"}, {"family": "Paige Lawrence", "given": "B", "initials": "B"}, {"family": "Rezaei", "given": "Mehran Habibi", "initials": "MH"}, {"family": "Ichihara", "given": "Gaku", "initials": "G"}, {"family": "Fereidouni", "given": "Sasan", "initials": "S"}], "type": "journal article", "published": "2021-01-05", "journal": {"title": "J Adv Res", "issn": "2090-1232", "volume": null, "issue": null, "issn-l": null}, "abstract": "The recent ongoing outbreak of coronavirus disease 2019 (COVID-19), still is an unsolved problem with a growing rate of infected cases and mortality worldwide. The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is targeting the angiotensin-converting enzyme 2 (ACE2) receptor and mostly causes a respiratory illness. Although acquired and resistance immunity is one of the most important aspects of alleviating the trend of the current pandemic; however, there is still a big gap of knowledge regarding the infection process, immunopathogenesis, recovery, and reinfection.\n\nTo answer the questions regarding \"the potential and probability of reinfection in COVID-19 infected cases\" or \"the efficiency and duration of SARS-CoV-2 infection-induced immunity against reinfection\" we critically evaluated the current reports on SARS-CoV-2 immunity and reinfection with special emphasis on comparative studies using animal models that generalize their finding about protection and reinfection. Also, the contribution of humoral immunity in the process of COVID-19 recovery and the role of ACE2 in virus infectivity and pathogenesis has been discussed. Furthermore, innate and cellular immunity and inflammatory responses in the disease and recovery conditions are reviewed and an overall outline of immunologic aspects of COVID-19 progression and recovery in three different stages are presented. Finally, we categorized the infected cases into four different groups based on the acquired immunity and the potential for reinfection.\n\nIn this review paper, we proposed a new strategy to predict the potential of reinfection in each identified category. This classification may help to distribute resources more meticulously to determine: who needs to be serologically tested for SARS-CoV-2 neutralizing antibodies, what percentage of the population is immune to the virus, and who needs to be vaccinated.", "doi": "10.1016/j.jare.2020.12.013", "pmid": "33520309", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2090-1232(20)30263-0"}, {"db": "pmc", "key": "PMC7832464"}], "notes": [], "created": "2021-02-04T18:31:22.502Z", "modified": "2021-02-04T18:31:53.526Z"}, {"entity": "publication", "iuid": "3dd3f252fe0c478dab38a085893b9814", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3dd3f252fe0c478dab38a085893b9814.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3dd3f252fe0c478dab38a085893b9814"}}, "title": "COVID-19 and seafarers' rights to shore leave, repatriation and medical assistance: a pilot study.", "authors": [{"family": "Hebbar", "given": "Anish Arvind", "initials": "AA"}, {"family": "Mukesh", "given": "Nitin", "initials": "N"}], "type": "journal article", "published": "2021-01-05", "journal": {"title": "Int Marit Health", "issn": "2081-3252", "issn-l": null, "volume": "71", "issue": "4", "pages": "217-228"}, "abstract": "The well-being of the world's 1.65 million seafarers is expected to be secured by the rights established under the Maritime Labour Convention (MLC), 2006 with active monitoring of its implementation by the flag administrations through the International Maritime Organisation (IMO) and International Labour Organisation (ILO). However, the substantial gains achieved since entry into force of MLC in August 2013 appear to have been severely dented by the COVID-19 global pandemic. The aim of the study was to examine, on a pilot basis, the disruptions and challenges to the observance of seafarers' rights to shore leave, repatriation and medical assistance as an immediate consequence of COVID-19.\r\n\r\nThe impact of COVID-19 on seafarers' rights was examined in three dimensions - shore leave, repatriation and medical assistance. Questionnaires were administered online from June to August 2020 to 450 seafarers, top 10 ship-management companies, 35 shipping companies and maritime administrations of top 5 seafarer supplying countries. The paper discusses the results of the survey.\r\n\r\nThe research revealed a previously unknown majority preference for shore leave, that diminished sharply during COVID-19. Impact on work-performance and well-being of seafarers was revealed with only a fifth of the seafarers having willingly agreed to an extension of contract. This study revealed incidence rates at 6 months into the pandemic of several parameters - delayed repatriations (21.44%) that includes crew with contract extensions (12.48%), crew with completed contract awaiting repatriation (8.96%) and crew that had exceeded 12-month continuous service (0.82%). Compensation, if provided, is meagre and was affecting ratings the most. Deprivation of medical assistance was also revealed.\r\n\r\nThe well being of seafarers would likely remain vulnerable to breaches, unless measures are put in place to safeguard the rights assured under MLC in the face of uncertainties caused by a pandemic such as COVID-19.", "doi": "10.5603/IMH.2020.0040", "pmid": "33394486", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "VM/OJS/J/72010"}], "notes": [], "created": "2021-01-05T15:23:14.849Z", "modified": "2021-06-18T09:44:21.762Z"}, {"entity": "publication", "iuid": "01e5014ff5dc46a1a5e0b0b849134ab7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01e5014ff5dc46a1a5e0b0b849134ab7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01e5014ff5dc46a1a5e0b0b849134ab7"}}, "title": "The Swedish COVID-19 intensive care cohort: Risk of ICU admission and ICU mortality.", "authors": [{"family": "Ahlstr\u00f6m", "given": "B", "initials": "B"}, {"family": "Frithiof", "given": "R", "initials": "R"}, {"family": "Hultstr\u00f6m", "given": "M", "initials": "M"}, {"family": "Larsson", "given": "I-M", "initials": "I"}, {"family": "Strandberg", "given": "G", "initials": "G"}, {"family": "Lipcsey", "given": "M", "initials": "M"}], "type": "journal-article", "published": "2021-01-04", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "0001-5172", "issn-l": null, "volume": "65", "issue": "4", "pages": "525-533"}, "abstract": "Abstract\r\nBackground: Several studies have recently addressed factors associated with severe Coronavirus disease 2019 (COVID-19); however, some medications and comorbidities have yet to be evaluated in a large matched cohort. We therefore explored the role of relevant comorbidities and medications in relation to the risk of intensive care unit (ICU) admission and mortality.\r\n\r\nMethods: All ICU COVID-19 patients in Sweden until 27 May 2020 were matched to population controls on age and sex to assess the risk of ICU admission. Cases were identified, comorbidities and medications were retrieved from high-quality registries. Three conditional logistic regression models were used for risk of ICU admission and three Cox proportional hazards models for risk of ICU mortality, one with comorbidities, one with medications and finally with both models combined, respectively.\r\n\r\nResults: We included 1981 patients and 7924 controls. Hypertension, type 2 diabetes mellitus, chronic renal failure, asthma, obesity, being a solid organ transplant recipient and immunosuppressant medications were independent risk factors of ICU admission and oral anticoagulants were protective. Stroke, asthma, chronic obstructive pulmonary disease and treatment with renin-angiotensin-aldosterone inhibitors (RAASi) were independent risk factors of ICU mortality in the pre-specified primary analyses; treatment with statins was protective. However, after adjusting for the use of continuous renal replacement therapy, RAASi were no longer an independent risk factor.\r\n\r\nConclusion: In our cohort oral anticoagulants were protective of ICU admission and statins was protective of ICU death. Several comorbidities and ongoing RAASi treatment were independent risk factors of ICU admission and ICU mortality.\r\n\r\nThis article is protected by", "doi": "10.1111/aas.13781", "pmid": "33438198", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-04T09:13:48.635Z", "modified": "2022-02-14T15:44:21.282Z"}, {"entity": "publication", "iuid": "fd2d575684ab488480008cfc0b6bae18", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fd2d575684ab488480008cfc0b6bae18.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fd2d575684ab488480008cfc0b6bae18"}}, "title": "SARS-CoV-2 encephalitis is a cytokine release syndrome: evidences from cerebrospinal fluid analyses", "authors": [{"family": "Pilotto", "given": "Andrea", "initials": "A"}, {"family": "Masciocchi", "given": "Stefano", "initials": "S"}, {"family": "Volonghi", "given": "Irene", "initials": "I"}, {"family": "De Giuli", "given": "Valeria", "initials": "V"}, {"family": "Caprioli", "given": "Francesca", "initials": "F"}, {"family": "Mariotto", "given": "Sara", "initials": "S"}, {"family": "Ferrari", "given": "Sergio", "initials": "S"}, {"family": "Bozzetti", "given": "Silvia", "initials": "S"}, {"family": "Imarisio", "given": "Alberto", "initials": "A"}, {"family": "Risi", "given": "Barbara", "initials": "B"}, {"family": "Premi", "given": "Enrico", "initials": "E"}, {"family": "Benussi", "given": "Alberto", "initials": "A"}, {"family": "Foc\u00e0", "given": "Emanuele", "initials": "E"}, {"family": "Castelli", "given": "Francesco", "initials": "F"}, {"family": "Zanusso", "given": "Gianluigi", "initials": "G"}, {"family": "Monaco", "given": "Salvatore", "initials": "S"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Gasparotti", "given": "Roberto", "initials": "R"}, {"family": "Zekeridou", "given": "Anastasia", "initials": "A"}, {"family": "McKeon", "given": "Andrew", "initials": "A"}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ"}, {"family": "Blennov", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Padovani", "given": "Alessandro", "initials": "A"}], "type": "journal-article", "published": "2021-01-04", "journal": {"title": "Clin Infect Dis", "issn": "1058-4838", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1093/cid/ciaa1933", "pmid": null, "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available in paper: Clinical features, imaging and CSF biochemical analyses of SARS-CoV-2 encephalitis cases", "description": null}, {"db": "NA", "key": "Available in paper: Clinical features, imaging and CSF biochemical analyses of COV-Enc cases", "description": null}], "notes": [], "created": "2021-01-05T15:20:43.277Z", "modified": "2021-06-18T10:02:34.967Z"}, {"entity": "publication", "iuid": "07ae93d4452b4555a315d7225e13863b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07ae93d4452b4555a315d7225e13863b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07ae93d4452b4555a315d7225e13863b"}}, "title": "Public Mobility and Social Media Attention in Response to COVID-19 in Sweden and Denmark.", "authors": [{"family": "Zhang", "given": "Le", "initials": "L"}, {"family": "Brikell", "given": "Isabell", "initials": "I"}, {"family": "Dalsgaard", "given": "S\u00f8ren", "initials": "S"}, {"family": "Chang", "given": "Zheng", "initials": "Z"}], "type": "journal article", "published": "2021-01-04", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "volume": "4", "issue": "1", "pages": "e2033478", "issn-l": null}, "abstract": null, "doi": "10.1001/jamanetworkopen.2020.33478", "pmid": "33394001", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "2774527"}], "notes": [], "created": "2021-01-07T10:04:55.103Z", "modified": "2021-02-26T08:46:59.814Z"}, {"entity": "publication", "iuid": "ddf4db5c2836473c816d391d7b547eb9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ddf4db5c2836473c816d391d7b547eb9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ddf4db5c2836473c816d391d7b547eb9"}}, "title": "More research is needed on the long-term effects of COVID-19 on children and adolescents.", "authors": [{"family": "Hertting", "given": "Olof", "initials": "O"}], "type": "editorial", "published": "2021-01-04", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": null, "issue": null, "pages": null}, "abstract": "Editorial", "doi": "10.1111/apa.15731", "pmid": "33395729", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-07T10:00:23.633Z", "modified": "2021-01-07T10:00:46.227Z"}, {"entity": "publication", "iuid": "52f8c81d169e44dfa9c5a9e9ee5622a8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/52f8c81d169e44dfa9c5a9e9ee5622a8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/52f8c81d169e44dfa9c5a9e9ee5622a8"}}, "title": "Little evidence for facemask use in children against COVID-19.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "editorial", "published": "2021-01-03", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": null, "issue": null, "pages": null}, "abstract": "Editorial", "doi": "10.1111/apa.15729", "pmid": "33393117", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-07T09:56:13.495Z", "modified": "2021-01-07T09:56:56.673Z"}, {"entity": "publication", "iuid": "6d40a9ed6d164a33a7968a3d377566db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6d40a9ed6d164a33a7968a3d377566db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6d40a9ed6d164a33a7968a3d377566db"}}, "title": "Treatment of severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19): a systematic review of in vitro, in vivo, and clinical trials.", "authors": [{"family": "Han", "given": "Young Joo", "initials": "YJ"}, {"family": "Lee", "given": "Keum Hwa", "initials": "KH"}, {"family": "Yoon", "given": "Sojung", "initials": "S"}, {"family": "Nam", "given": "Seoung Wan", "initials": "SW"}, {"family": "Ryu", "given": "Seohyun", "initials": "S"}, {"family": "Seong", "given": "Dawon", "initials": "D"}, {"family": "Kim", "given": "Jae Seok", "initials": "JS"}, {"family": "Lee", "given": "Jun Young", "initials": "JY"}, {"family": "Yang", "given": "Jae Won", "initials": "JW"}, {"family": "Lee", "given": "Jinhee", "initials": "J"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Hong", "given": "Sung Hwi", "initials": "SH"}, {"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Smith", "given": "Lee", "initials": "L"}, {"family": "Oh", "given": "Hans", "initials": "H"}, {"family": "Ghayda", "given": "Ramy Abou", "initials": "RA"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Effenberger", "given": "Maria", "initials": "M"}, {"family": "Kresse", "given": "Daniela", "initials": "D"}, {"family": "Denicol\u00f2", "given": "Sara", "initials": "S"}, {"family": "Kang", "given": "Woosun", "initials": "W"}, {"family": "Jacob", "given": "Louis", "initials": "L"}, {"family": "Shin", "given": "Hanwul", "initials": "H"}, {"family": "Shin", "given": "Jae Il", "initials": "JI"}], "type": "journal article", "published": "2021-01-01", "journal": {"title": "Theranostics", "issn": "1838-7640", "volume": "11", "issue": "3", "pages": "1207-1231", "issn-l": null}, "abstract": "Rationale: Coronavirus disease 2019 (COVID-19) has spread worldwide and poses a threat to humanity. However, no specific therapy has been established for this disease yet. We conducted a systematic review to highlight therapeutic agents that might be effective in treating COVID-19. Methods: We searched Medline, Medrxiv.org, and reference lists of relevant publications to identify articles of in vitro, in vivo, and clinical studies on treatments for severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and COVID-19 published in English until the last update on October 11, 2020. Results: We included 36 studies on SARS, 30 studies on MERS, and 10 meta-analyses on SARS and MERS in this study. Through 12,200 title and 830 full-text screenings for COVID-19, eight in vitro studies, 46 randomized controlled trials (RCTs) on 6,886 patients, and 29 meta-analyses were obtained and investigated. There was no therapeutic agent that consistently resulted in positive outcomes across SARS, MERS, and COVID-19. Remdesivir showed a therapeutic effect for COVID-19 in two RCTs involving the largest number of total participants (n = 1,461). Other therapies that showed an effect in at least two RCTs for COVID-19 were sofosbuvir/daclatasvir (n = 114), colchicine (n = 140), IFN-\u03b21b (n = 193), and convalescent plasma therapy (n = 126). Conclusions: This review provides information to help establish treatment and research directions for COVID-19 based on currently available evidence. Further RCTs are required.", "doi": "10.7150/thno.48342", "pmid": "33391531", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "thnov11p1207"}, {"db": "pmc", "key": "PMC7738873"}], "notes": [], "created": "2021-01-07T11:19:21.921Z", "modified": "2021-01-07T11:19:21.947Z"}, {"entity": "publication", "iuid": "53ae2386675c4a4ba33a03cf8ce33fb7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53ae2386675c4a4ba33a03cf8ce33fb7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53ae2386675c4a4ba33a03cf8ce33fb7"}}, "title": "The ABCs of Covid-19 prevention in Malawi: Authority, benefits, and costs of compliance.", "authors": [{"family": "Kao", "given": "Kristen", "initials": "K"}, {"family": "Lust", "given": "Ellen", "initials": "E"}, {"family": "Dulani", "given": "Boniface", "initials": "B"}, {"family": "Ferree", "given": "Karen E", "initials": "KE"}, {"family": "Harris", "given": "Adam S", "initials": "AS"}, {"family": "Metheney", "given": "Erica", "initials": "E"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "World Dev", "issn": "0305-750X", "volume": "137", "issue": null, "pages": "105167", "issn-l": null}, "abstract": "A wide array of authorities-from religious leaders to government ministers-call upon citizens to take preventative measures against Covid-19. Which authorities can most effectively gain public compliance, and which measures will the public take up? Moreover, do people comply with authorities out of respect for their legitimacy, due to their expertise, or for fear of sanctioning? Answers to these questions are important for development practitioners, who need to understand how different partnerships might affect health behavior, and for scholars interested in understanding authority, legitimacy, and compliance. We explore these questions using a conjoint experiment embedded in a telephone survey of 641 Malawians. Individuals in our sample are more likely to say that they will comply with precautionary measures when the costs are low and expected benefits are high. Respondents view both traditional authorities and hospital heads as legitimately issuing directives and having the ability to monitor and sanction non-compliance, but appear to comply more with hospital heads and to do so out of respect for their expertise. These results emphasize how who issues directives affects whether individuals comply and provides insights as to why they do so. The findings also reflect individuals' cost-benefit calculations when considering precautionary measures, highlighting the importance of steps that can reduce costs (e.g., food security or income measures) or accurately reflect risks (e.g., information signaling the prevalence of Covid-19). The study not only helps to address the Coronavirus crisis but also has important implications for broader questions of authority and compliance.", "doi": "10.1016/j.worlddev.2020.105167", "pmid": "32904501", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0305-750X(20)30294-1"}, {"db": "pii", "key": "105167"}, {"db": "pmc", "key": "PMC7455236"}], "notes": [], "created": "2020-12-03T16:14:55.886Z", "modified": "2020-12-03T16:14:55.900Z"}, {"entity": "publication", "iuid": "d12ec989605142b5bc38043f089487db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d12ec989605142b5bc38043f089487db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d12ec989605142b5bc38043f089487db"}}, "title": "Temporal increase in D614G mutation of SARS-CoV-2 in the Middle East and North Africa.", "authors": [{"family": "Sallam", "given": "Malik", "initials": "M"}, {"family": "Ababneh", "given": "Nidaa A", "initials": "NA"}, {"family": "Dababseh", "given": "Deema", "initials": "D"}, {"family": "Bakri", "given": "Faris G", "initials": "FG"}, {"family": "Mahafzah", "given": "Azmi", "initials": "A"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": "7", "issue": "1", "pages": "e06035", "issn-l": null}, "abstract": "Phylogeny construction can help to reveal evolutionary relatedness among molecular sequences. The spike ( S) gene of SARS-CoV-2 is the subject of an immune selective pressure which increases the variability in such region. This study aimed to identify mutations in the S gene among SARS-CoV-2 sequences collected in the Middle East and North Africa (MENA), focusing on the D614G mutation, that has a presumed fitness advantage. Another aim was to analyze the S gene sequences phylogenetically.\n\nThe SARS-CoV-2 S gene sequences collected in the MENA were retrieved from the GISAID public database, together with its metadata. Mutation analysis was conducted in Molecular Evolutionary Genetics Analysis software. Phylogenetic analysis was done using maximum likelihood (ML) and Bayesian methods.\n\nA total of 553 MENA sequences were analyzed and the most frequent S gene mutations included: D614G = 435, Q677H = 8, and V6F = 5. A significant increase in the proportion of D614G was noticed from (63.0%) in February 2020, to (98.5%) in June 2020 (p < 0.001). Two large phylogenetic clusters were identified via ML analysis, which showed an evidence of inter-country mixing of sequences, which dated back to February 8, 2020 and March 15, 2020 (median estimates). The mean evolutionary rate for SARS-CoV-2 was about 6.5 \u00d7 10-3 substitutions/site/year based on large clusters' Bayesian analyses.\n\nThe D614G mutation appeared to be taking over the COVID-19 infections in the MENA. Bayesian analysis suggested that SARS-CoV-2 might have been circulating in MENA earlier than previously reported.", "doi": "10.1016/j.heliyon.2021.e06035", "pmid": "33495741", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)00140-7"}, {"db": "pmc", "key": "PMC7817394"}], "notes": [], "created": "2021-01-29T15:21:33.803Z", "modified": "2021-02-26T08:45:14.457Z"}, {"entity": "publication", "iuid": "b45d9aadb46742d991a0e44c8f1c65b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b45d9aadb46742d991a0e44c8f1c65b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b45d9aadb46742d991a0e44c8f1c65b4"}}, "title": "Sex differences in COVID-19: the role of androgens in disease severity and progression.", "authors": [{"family": "Mohamed", "given": "Mohamed S", "initials": "MS"}, {"family": "Moulin", "given": "Thiago C", "initials": "TC", "orcid": "0000-0001-7811-5383", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5480e69e1fd4d3cb11c758c637ab663.json"}}, {"family": "Schi\u00f6th", "given": "Helgi B", "initials": "HB"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Endocrine", "issn": "1559-0100", "issn-l": "1355-008X", "volume": "71", "issue": "1", "pages": "3-8"}, "abstract": "Throughout the SARS-CoV2 pandemic, multiple reports show higher percentages of hospitalization, morbidity, and mortality among men than women, indicating that men are more affected by COVID-19. The pathophysiology of this difference is yet not established, but recent studies suggest that sex hormones may influence the viral infectivity process. Here, we review the current evidence of androgen sensitivity as a decisive factor for COVID-19 disease severity.\n\nRelevant literature investigating the role of androgens in COVID-19 was assessed. Further, we describe several drugs suggested as beneficial for COVID-19 treatment related to androgen pathways. Lastly, we looked at androgen sensitivity as a predictor for COVID-19 progression and ongoing clinical trials on androgen suppression therapies as a line of treatment.\n\nSARS-COV2 virus spike proteins utilize Transmembrane protease serine 2 (TMPRSS2) for host entry. Androgen receptors are transcription promoters for TMPRSS2 and can, therefore, facilitate SARS-COV2 entry. Variants in the androgen receptor gene correlate with androgen sensitivity and are implicated in diseases like androgenetic alopecia and prostate cancer, conditions that have been associated with worse COVID-19 outcomes and hospitalization.\n\nAndrogen's TMPRSS2-mediated actions might explain both the low fatalities observed in prepubertal children and the differences between sexes regarding SARS-COV2 infection. Androgen sensitivity may be a critical factor in determining COVID-19 disease severity, and sensitivity tests can, therefore, help in predicting patient outcomes.", "doi": "10.1007/s12020-020-02536-6", "pmid": "33179220", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7657570"}, {"db": "pii", "key": "10.1007/s12020-020-02536-6"}], "notes": [], "created": "2020-11-17T18:06:21.476Z", "modified": "2023-01-13T13:22:07.725Z"}, {"entity": "publication", "iuid": "62b7afd26bb74034adc40ba88cb53b7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/62b7afd26bb74034adc40ba88cb53b7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/62b7afd26bb74034adc40ba88cb53b7e"}}, "title": "SARS-CoV-2, testosterone and frailty in males (PROTEGGIMI): A multidimensional research project.", "authors": [{"family": "Salonia", "given": "Andrea", "initials": "A", "orcid": "0000-0002-0595-7165", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/940b454070ba44e8ad349d3c8f6c06c3.json"}}, {"family": "Corona", "given": "Giovanni", "initials": "G", "orcid": "0000-0002-9894-2885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a16ac7355400404b898586d50aabdb10.json"}}, {"family": "Giwercman", "given": "Aleksander", "initials": "A", "orcid": "0000-0001-5816-0785", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0fd6b6404f946e7aab84d821930a751.json"}}, {"family": "Maggi", "given": "Mario", "initials": "M", "orcid": "0000-0003-3267-4221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/088328c481194b519fe8c3b994b186f8.json"}}, {"family": "Minhas", "given": "Suks", "initials": "S", "orcid": "0000-0001-6516-619X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7f662b0ec134b2197ef8f15deb12468.json"}}, {"family": "Nappi", "given": "Rossella E", "initials": "RE", "orcid": "0000-0002-5216-9882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c88e19ec3901486e9a11f8bfb30a77be.json"}}, {"family": "Sofikitis", "given": "Nikolaos", "initials": "N", "orcid": "0000-0003-1528-4029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/878fcbbf78bf4f98bc7622484e44415d.json"}}, {"family": "Vignozzi", "given": "Linda", "initials": "L", "orcid": "0000-0003-0907-0630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40adf501a0ac4e3ab32759026e837fce.json"}}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Andrology", "issn": "2047-2927", "volume": "9", "issue": "1", "pages": "19-22", "issn-l": null}, "abstract": "Preliminary published data depict a much greater prevalence of males with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) referred for intensive care unit admission and severe sequelae in several countries. In this context, males seem to not only be more susceptible to the infection compared to female subjects, at least in Western countries, but their case fatality rate attributable to SARS-CoV-2 infection is also highest. Therefore, we may speculate that the different hormonal milieu could have a more profound pathophysiological role in association with SARS-CoV-2, with endogenous testosterone leaving men more prone to develop more serious complications related to the SARS-CoV-2 infection. Another option is that SARS-CoV-2 infection per se causes an acute stage of male hypogonadism, the depletion of androgenic action triggering serious or an even fatal course of the disease. Therefore, we strongly advocate the development of a prospective multidimensional andrological translational research project in men, which we called the PROTEGGIMI study. In this Opinion Article, we will not only highlight novel research activity in this area but also invite other researchers and learned scientific societies to join us in our efforts to understand an important and very newly discovered gap in knowledge, which may have serious implications for the lives of millions of men.", "doi": "10.1111/andr.12811", "pmid": "32369678", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-10T07:29:32.686Z", "modified": "2021-12-06T13:08:06.084Z"}, {"entity": "publication", "iuid": "586f3b487ead4831bce4bcfd52919638", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/586f3b487ead4831bce4bcfd52919638.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/586f3b487ead4831bce4bcfd52919638"}}, "title": "Prothrombotic changes in patients with COVID-19 are associated with disease severity and mortality.", "authors": [{"family": "von Meijenfeldt", "given": "Fien A", "initials": "FA"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Adelmeijer", "given": "Jelle", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A"}, {"family": "Rudberg", "given": "Ann-Sofie", "initials": "AS"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Thalin", "given": "Charlotte", "initials": "C"}, {"family": "Lisman", "given": "Ton", "initials": "T", "orcid": "0000-0002-3503-7140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7431e810d13c443ca5dacbf5d368e60b.json"}}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Res Pract Thromb Haemost", "issn": "2475-0379", "issn-l": null, "volume": "5", "issue": "1", "pages": "132-141"}, "abstract": "Patients with severe coronavirus disease 2019 (COVID-19) are at significant risk of thrombotic complications. However, their prothrombotic state is incompletely understood. Therefore, we measured in vivo activation markers of hemostasis, plasma levels of hemostatic proteins, and functional assays of coagulation and fibrinolysis in plasma from patients with COVID-19 and determined their association with disease severity and 30-day mortality.\n\nWe included 102 patients with COVID-19 receiving various levels of respiratory support admitted to general wards, intermediate units, or intensive care units and collected plasma samples shortly after hospital admission.\n\nPatients with COVID-19 with higher respiratory support had increased in vivo activation of coagulation and fibrinolysis, as reflected by higher plasma levels of d-dimer, thrombin-antithrombin, and plasmin-antiplasmin complexes as compared to patients with no to minimal respiratory support and healthy controls. Moreover, the patients with COVID-19 with higher respiratory support exhibited substantial ex vivo thrombin generation and lower ex vivo fibrinolytic capacity, despite higher doses of anticoagulant therapy compared to less severely ill patients. Fibrinogen, factor VIII, and von Willebrand factor levels increased, and ADAMTS13 levels decreased with increasing respiratory support in patients with COVID-19. Low platelet count; low levels of prothrombin, antithrombin, and ADAMTS13; and high levels of von Willebrand factor were associated with short-term mortality.\n\nSevere COVID-19 is associated with prothrombotic changes with increased in vivo activation of coagulation and fibrinolysis, despite anticoagulant therapy.", "doi": "10.1002/rth2.12462", "pmid": "33537537", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "RTH212462"}, {"db": "pmc", "key": "PMC7845083"}], "notes": [], "created": "2021-01-05T09:54:08.916Z", "modified": "2021-12-12T18:06:52.709Z"}, {"entity": "publication", "iuid": "b80e3c19bd144eefa0375ac53985e99d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b80e3c19bd144eefa0375ac53985e99d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b80e3c19bd144eefa0375ac53985e99d"}}, "title": "Priority setting during the COVID-19 pandemic: going beyond vaccines", "authors": [{"family": "Williams", "given": "Iestyn", "initials": "I"}, {"family": "Essue", "given": "Beverley", "initials": "B"}, {"family": "Nouvet", "given": "Elysee", "initials": "E"}, {"family": "Sandman", "given": "Lars", "initials": "L"}, {"family": "Razavi", "given": "S Donya", "initials": "SD"}, {"family": "Noorulhuda", "given": "Mariam", "initials": "M"}, {"family": "Goold", "given": "Susan", "initials": "S"}, {"family": "Danis", "given": "Marion", "initials": "M"}, {"family": "Biemba", "given": "Godfrey", "initials": "G"}, {"family": "Abelson", "given": "Julia", "initials": "J"}, {"family": "Kapiriri", "given": "Lydia", "initials": "L"}], "type": "journal-article", "published": "2021-01-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "1", "pages": "e004686", "issn-l": "2059-7908"}, "abstract": null, "doi": "10.1136/bmjgh-2020-004686", "pmid": "33461979", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-20T14:54:55.855Z", "modified": "2021-01-22T09:17:09.826Z"}, {"entity": "publication", "iuid": "c464dbf3e26d474cb38b3d0e0ffed683", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c464dbf3e26d474cb38b3d0e0ffed683.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c464dbf3e26d474cb38b3d0e0ffed683"}}, "title": "Precision shielding for COVID-19: metrics of assessment and feasibility of deployment.", "authors": [{"family": "Ioannidis", "given": "John P A", "initials": "JPA"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "1", "issn-l": "2059-7908"}, "abstract": "The ability to preferentially protect high-risk groups in COVID-19 is hotly debated. Here, the aim is to present simple metrics of such precision shielding of people at high risk of death after infection by SARS-CoV-2; demonstrate how they can estimated; and examine whether precision shielding was successfully achieved in the first COVID-19 wave. The shielding ratio, S, is defined as the ratio of prevalence of infection among people in a high-risk group versus among people in a low-risk group. The contrasted risk groups examined here are according to age (\u226570 vs <70 years), and institutionalised (nursing home) setting. For age-related precision shielding, data were used from large seroprevalence studies with separate prevalence data for elderly versus non-elderly and with at least 1000 assessed people\u226570 years old. For setting-related precision shielding, data were analysed from 10 countries where information was available on numbers of nursing home residents, proportion of nursing home residents among COVID-19 deaths and overall population infection fatality rate (IFR). Across 17 seroprevalence studies, the shielding ratio S for elderly versus non-elderly varied between 0.4 (substantial shielding) and 1.6 (substantial inverse protection, that is, low-risk people being protected more than high-risk people). Five studies in the USA all yielded S=0.4-0.8, consistent with some shielding being achieved, while two studies in China yielded S=1.5-1.6, consistent with inverse protection. Assuming 25% IFR among nursing home residents, S values for nursing home residents ranged from 0.07 to 3.1. The best shielding was seen in South Korea (S=0.07) and modest shielding was achieved in Israel, Slovenia, Germany and Denmark. No shielding was achieved in Hungary and Sweden. In Belgium (S=1.9), the UK (S=2.2) and Spain (S=3.1), nursing home residents were far more frequently infected than the rest of the population. In conclusion, the experience from the first wave of COVID-19 suggests that different locations and settings varied markedly in the extent to which they protected high-risk groups. Both effective precision shielding and detrimental inverse protection can happen in real-life circumstances. COVID-19 interventions should seek to achieve maximal precision shielding.", "doi": "10.1136/bmjgh-2020-004614", "pmid": "33514595", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-004614"}, {"db": "pmc", "key": "PMC7849322"}], "notes": [], "created": "2021-02-04T18:40:10.775Z", "modified": "2021-02-04T18:40:33.901Z"}, {"entity": "publication", "iuid": "3d2760fc6be84cb79efc1d8324e0cee3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3d2760fc6be84cb79efc1d8324e0cee3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3d2760fc6be84cb79efc1d8324e0cee3"}}, "title": "Impact of the COVID\u201019 pandemic on statistical design and analysis plans for multidomain intervention clinical trials: Experience from World\u2010Wide FINGERS", "authors": [{"family": "R\u00f6hr", "given": "Susanne", "initials": "S"}, {"family": "Arai", "given": "Hidenori", "initials": "H"}, {"family": "Mangialasche", "given": "Francesca", "initials": "F"}, {"family": "Matsumoto", "given": "Nanae", "initials": "N"}, {"family": "Peltonen", "given": "Markku", "initials": "M"}, {"family": "Raman", "given": "Rema", "initials": "R"}, {"family": "Riedel\u2010Heller", "given": "Steffi G", "initials": "SG"}, {"family": "Sakurai", "given": "Takashi", "initials": "T"}, {"family": "Snyder", "given": "Heather M", "initials": "HM"}, {"family": "Sugimoto", "given": "Taiki", "initials": "T"}, {"family": "Carrillo", "given": "Maria", "initials": "M"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Espeland", "given": "Mark A", "initials": "MA"}, {"family": null, "given": "", "initials": ""}], "type": "journal-article", "published": "2021-01-00", "journal": {"title": "Alzheimers Dement (N Y)", "issn": "2352-8737", "issn-l": null, "volume": "7", "issue": "1", "pages": "e12143"}, "abstract": "The coronavirus disease-19 (COVID-19) pandemic presents challenges to the conduct of randomized clinical trials of lifestyle interventions.\r\n\r\nWorld-Wide FINGERS is an international network of clinical trials to assess the impact of multidomain lifestyle intervention on cognitive decline in at-risk adults. Individual trials are tailoring successful approaches from the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) to local cultures and environments. The network convened a forum for researchers to discuss statistical design and analysis issues they faced during the pandemic. We report on experiences of three trials that, at various stages of conduct, altered designs and analysis plans to navigate these issues. We provide recommendations for future trials to consider as they develop and launch behavioral intervention trials.\r\n\r\nThe pandemic led researchers to change recruitment plans, interrupt timelines for assessments and intervention delivery, and move to remote intervention and assessment protocols. The necessity of these changes add emphasis to the importance, in study design and analysis, of intention to treat approaches, flexibility, within-site stratification, interim power projections, and sensitivity analyses.\r\n\r\nRobust approaches to study design and analysis are critical to negotiate issues related to the intervention. The world-wide network of similarly oriented clinical trials will allow us to evaluate the effectiveness of responses to the pandemic across cultures, local environments, and phases of the pandemic.", "doi": "10.1002/trc2.12143", "pmid": "33738333", "labels": {"Category: Public Health": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "TRC212143"}, {"db": "pmc", "key": "PMC7948446"}], "notes": [], "created": "2021-03-22T10:32:35.047Z", "modified": "2021-11-18T12:57:15.265Z"}, {"entity": "publication", "iuid": "3dfd0924e5504124abeb6987b92920b5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3dfd0924e5504124abeb6987b92920b5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3dfd0924e5504124abeb6987b92920b5"}}, "title": "Immune determinants of COVID-19 disease presentation and severity.", "authors": [{"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956", "volume": "27", "issue": "1", "pages": "28-33"}, "abstract": "COVID-19, caused by SARS-CoV-2 infection, is mild to moderate in the majority of previously healthy individuals, but can cause life-threatening disease or persistent debilitating symptoms in some cases. The most important determinant of disease severity is age, with individuals over 65 years having the greatest risk of requiring intensive care, and men are more susceptible than women. In contrast to other respiratory viral infections, young children seem to be less severely affected. It is now clear that mild to severe acute infection is not the only outcome of COVID-19, and long-lasting symptoms are also possible. In contrast to severe acute COVID-19, such 'long COVID' is seemingly more likely in women than in men. Also, postinfectious hyperinflammatory disease has been described as an additional outcome after SARS-CoV-2 infection. Here I discuss our current understanding of the immunological determinants of COVID-19 disease presentation and severity and relate this to known immune-system differences between young and old people and between men and women, and other factors associated with different disease presentations and severity.", "doi": "10.1038/s41591-020-01202-8", "pmid": "33442016", "labels": {"Category: Health": null, "Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-020-01202-8"}], "notes": [], "created": "2021-01-15T11:23:24.748Z", "modified": "2023-07-13T11:26:40.799Z"}, {"entity": "publication", "iuid": "f035e7ee455c4eb08c507a8789e62c5c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f035e7ee455c4eb08c507a8789e62c5c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f035e7ee455c4eb08c507a8789e62c5c"}}, "title": "How two concurrent pandemics put a spoke in the wheel of intensive pig production.", "authors": [{"family": "Millet", "given": "Sam", "initials": "S"}, {"family": "De Smet", "given": "Sarah", "initials": "S"}, {"family": "Knol", "given": "Egbert F", "initials": "EF"}, {"family": "Bee", "given": "Giuseppe", "initials": "G"}, {"family": "Trevisi", "given": "Paolo", "initials": "P"}, {"family": "Vigors", "given": "Stafford", "initials": "S"}, {"family": "Nilsson", "given": "Katja", "initials": "K"}, {"family": "Van Meensel", "given": "Jef", "initials": "J"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Anim Front", "issn": "2160-6064", "volume": "11", "issue": "1", "pages": "14-18", "issn-l": null}, "abstract": null, "doi": "10.1093/af/vfaa051", "pmid": "33575094", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "vfaa051"}, {"db": "pmc", "key": "PMC7863338"}], "notes": [], "created": "2021-02-15T12:54:51.195Z", "modified": "2021-02-15T12:54:51.217Z"}, {"entity": "publication", "iuid": "8c437356108544589e9b347f78ebee8b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c437356108544589e9b347f78ebee8b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c437356108544589e9b347f78ebee8b"}}, "title": "High levels of anxiety during the COVID-19 pandemic as a risk factor of clinical worsening in patients with severe asthma", "authors": [{"family": "Lacwik", "given": "Piotr", "initials": "P"}, {"family": "Szyd\u0142owska", "given": "Dorota", "initials": "D"}, {"family": "Kupczyk", "given": "Maciej", "initials": "M"}, {"family": "Pa\u0142czy\u0144ski", "given": "Cezary", "initials": "C"}, {"family": "Kuna", "given": "Piotr", "initials": "P"}], "type": "journal-article", "published": "2021-01-00", "journal": {"title": "The Journal of Allergy and Clinical Immunology: In Practice", "issn": "2213-2198", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.jaip.2020.12.060", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-15T13:17:12.974Z", "modified": "2021-02-26T08:45:48.448Z"}, {"entity": "publication", "iuid": "47b30bbdaf1c4ae592b17ab88b7f8376", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47b30bbdaf1c4ae592b17ab88b7f8376.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47b30bbdaf1c4ae592b17ab88b7f8376"}}, "title": "Detecting COVID-19 infection hotspots in England using large-scale self-reported data from a mobile application: a prospective, observational study.", "authors": [{"family": "Varsavsky", "given": "Thomas", "initials": "T"}, {"family": "Graham", "given": "Mark S", "initials": "MS"}, {"family": "Canas", "given": "Liane S", "initials": "LS"}, {"family": "Ganesh", "given": "Sajaysurya", "initials": "S"}, {"family": "Capdevila Pujol", "given": "Joan", "initials": "J"}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Murray", "given": "Benjamin", "initials": "B"}, {"family": "Modat", "given": "Marc", "initials": "M"}, {"family": "Jorge Cardoso", "given": "M", "initials": "M"}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Nguyen", "given": "Long H", "initials": "LH"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Gomez", "given": "Maria F", "initials": "MF"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "Davies", "given": "Richard", "initials": "R"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Spector", "given": "Tim D", "initials": "TD"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Lancet Public Health", "issn": "2468-2667", "issn-l": null, "volume": "6", "issue": "1", "pages": "e21-e29"}, "abstract": "As many countries seek to slow the spread of COVID-19 without reimposing national restrictions, it has become important to track the disease at a local level to identify areas in need of targeted intervention.\n\nIn this prospective, observational study, we did modelling using longitudinal, self-reported data from users of the COVID Symptom Study app in England between March 24, and Sept 29, 2020. Beginning on April 28, in England, the Department of Health and Social Care allocated RT-PCR tests for COVID-19 to app users who logged themselves as healthy at least once in 9 days and then reported any symptom. We calculated incidence of COVID-19 using the invited swab (RT-PCR) tests reported in the app, and we estimated prevalence using a symptom-based method (using logistic regression) and a method based on both symptoms and swab test results. We used incidence rates to estimate the effective reproduction number, R(t), modelling the system as a Poisson process and using Markov Chain Monte-Carlo. We used three datasets to validate our models: the Office for National Statistics (ONS) Community Infection Survey, the Real-time Assessment of Community Transmission (REACT-1) study, and UK Government testing data. We used geographically granular estimates to highlight regions with rapidly increasing case numbers, or hotspots.\n\nFrom March 24 to Sept 29, 2020, a total of 2 873 726 users living in England signed up to use the app, of whom 2 842 732 (98\u00b79%) provided valid age information and daily assessments. These users provided a total of 120 192 306 daily reports of their symptoms, and recorded the results of 169 682 invited swab tests. On a national level, our estimates of incidence and prevalence showed a similar sensitivity to changes to those reported in the ONS and REACT-1 studies. On Sept 28, 2020, we estimated an incidence of 15 841 (95% CI 14 023-17 885) daily cases, a prevalence of 0\u00b753% (0\u00b745-0\u00b760), and R(t) of 1\u00b717 (1\u00b715-1\u00b719) in England. On a geographically granular level, on Sept 28, 2020, we detected 15 (75%) of the 20 regions with highest incidence according to government test data.\n\nOur method could help to detect rapid case increases in regions where government testing provision is lower. Self-reported data from mobile applications can provide an agile resource to inform policy makers during a quickly moving pandemic, serving as a complementary resource to more traditional instruments for disease surveillance.\n\nZoe Global, UK Government Department of Health and Social Care, Wellcome Trust, UK Engineering and Physical Sciences Research Council, UK National Institute for Health Research, UK Medical Research Council and British Heart Foundation, Alzheimer's Society, Chronic Disease Research Foundation.", "doi": "10.1016/S2468-2667(20)30269-3", "pmid": "33278917", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7785969"}, {"db": "pii", "key": "S2468-2667(20)30269-3"}], "notes": [], "created": "2020-12-10T09:19:53.222Z", "modified": "2023-06-19T15:27:26.581Z"}, {"entity": "publication", "iuid": "578b0f69f60c4bfe8fe9b74ae778aa67", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/578b0f69f60c4bfe8fe9b74ae778aa67.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/578b0f69f60c4bfe8fe9b74ae778aa67"}}, "title": "Dementia research in 2020: moving forward despite the COVID-19 pandemic", "authors": [{"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Mangialasche", "given": "Francesca", "initials": "F"}], "type": "journal-article", "published": "2021-01-00", "journal": {"title": "The Lancet Neurology", "issn": "1474-4422", "issn-l": null, "volume": "20", "issue": "1", "pages": "3-5"}, "abstract": null, "doi": "10.1016/s1474-4422(20)30453-1", "pmid": "33340483", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1474-4422(20)30453-1"}], "notes": [], "created": "2021-01-10T18:08:57.324Z", "modified": "2021-07-14T07:50:57.871Z"}, {"entity": "publication", "iuid": "d98fd68a9852405a9a40f2927f65eaf4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d98fd68a9852405a9a40f2927f65eaf4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d98fd68a9852405a9a40f2927f65eaf4"}}, "title": "Cancer and Risk of COVID-19 Through a General Community Survey.", "authors": [{"family": "Lee", "given": "Karla A", "initials": "KA", "orcid": "0000-0001-5904-5586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/acab9243ce90490f93e8fc4bb3e7f25f.json"}}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Sikavi", "given": "Daniel R", "initials": "DR"}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Nguyen", "given": "Long H", "initials": "LH"}, {"family": "Bowyer", "given": "Ruth C E", "initials": "RCE"}, {"family": "Cardoso", "given": "M Jorge", "initials": "MJ"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Freidin", "given": "Maxim B", "initials": "MB"}, {"family": "Gomez", "given": "Maria", "initials": "M"}, {"family": "Graham", "given": "Mark", "initials": "M"}, {"family": "Guo", "given": "Chuan-Guo", "initials": "CG"}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Kwon", "given": "Sohee", "initials": "S"}, {"family": "Lo", "given": "Chun-Han", "initials": "CH"}, {"family": "Lochlainn", "given": "Mary Ni", "initials": "MN"}, {"family": "Menni", "given": "Cristina", "initials": "C"}, {"family": "Murray", "given": "Benjamin", "initials": "B"}, {"family": "Mehta", "given": "Raaj", "initials": "R"}, {"family": "Song", "given": "Mingyang", "initials": "M"}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Bataille", "given": "Veronique", "initials": "V"}, {"family": "Varsavsky", "given": "Thomas", "initials": "T"}, {"family": "Visconti", "given": "Alessia", "initials": "A"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Spector", "given": "Tim D", "initials": "TD"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "COPE consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Oncologist", "issn": "1549-490X", "volume": "26", "issue": "1", "pages": "e182-e185", "issn-l": null}, "abstract": "Individuals with cancer may be at high risk for coronavirus disease 2019 (COVID-19) and adverse outcomes. However, evidence from large population-based studies examining whether cancer and cancer-related therapy exacerbates the risk of COVID-19 infection is still limited. Data were collected from the COVID Symptom Study smartphone application since March 29 through May 8, 2020. Among 23,266 participants with cancer and 1,784,293 without cancer, we documented 10,404 reports of a positive COVID-19 test. Compared with participants without cancer, those living with cancer had a 60% increased risk of a positive COVID-19 test. Among patients with cancer, current treatment with chemotherapy or immunotherapy was associated with a 2.2-fold increased risk of a positive test. The association between cancer and COVID-19 infection was stronger among participants >65 years and males. Future studies are needed to identify subgroups by tumor types and treatment regimens who are particularly at risk for COVID-19 infection and adverse outcomes.", "doi": "10.1634/theoncologist.2020-0572", "pmid": "32845538", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7460944"}], "notes": [], "created": "2020-12-07T10:25:23.865Z", "modified": "2023-06-19T15:27:14.731Z"}, {"entity": "publication", "iuid": "21351024191b4d2489d3ed081cb1a9a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/21351024191b4d2489d3ed081cb1a9a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/21351024191b4d2489d3ed081cb1a9a6"}}, "title": "Calling for pan-European commitment for rapid and sustained reduction in SARS-CoV-2 infections", "authors": [{"family": "Priesemann", "given": "Viola", "initials": "V"}, {"family": "Brinkmann", "given": "Melanie M", "initials": "MM"}, {"family": "Ciesek", "given": "Sandra", "initials": "S"}, {"family": "Cuschieri", "given": "Sarah", "initials": "S"}, {"family": "Czypionka", "given": "Thomas", "initials": "T"}, {"family": "Giordano", "given": "Giulia", "initials": "G"}, {"family": "Gurdasani", "given": "Deepti", "initials": "D"}, {"family": "Hanson", "given": "Claudia", "initials": "C"}, {"family": "Hens", "given": "Niel", "initials": "N"}, {"family": "Iftekhar", "given": "Emil", "initials": "E"}, {"family": "Kelly-Irving", "given": "Michelle", "initials": "M"}, {"family": "Klimek", "given": "Peter", "initials": "P"}, {"family": "Kretzschmar", "given": "Mirjam", "initials": "M"}, {"family": "Peichl", "given": "Andreas", "initials": "A"}, {"family": "Perc", "given": "Matja\u017e", "initials": "M"}, {"family": "Sannino", "given": "Francesco", "initials": "F"}, {"family": "Schernhammer", "given": "Eva", "initials": "E"}, {"family": "Schmidt", "given": "Alexander", "initials": "A"}, {"family": "Staines", "given": "Anthony", "initials": "A"}, {"family": "Szczurek", "given": "Ewa", "initials": "E"}], "type": "journal-article", "published": "2021-01-00", "journal": {"title": "Lancet", "issn": "0140-6736", "volume": "397", "issue": "10269", "pages": "92-93", "issn-l": null}, "abstract": null, "doi": "10.1016/s0140-6736(20)32625-8", "pmid": null, "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-10T17:37:45.890Z", "modified": "2021-07-14T07:47:49.897Z"}, {"entity": "publication", "iuid": "e21f5e5fd27d47eaab5a97c944fe7a4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e21f5e5fd27d47eaab5a97c944fe7a4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e21f5e5fd27d47eaab5a97c944fe7a4c"}}, "title": "Behaviour adoption approaches during public health emergencies: implications for the COVID-19 pandemic and beyond.", "authors": [{"family": "Jalloh", "given": "Mohamed F", "initials": "MF"}, {"family": "Nur", "given": "Aasli A", "initials": "AA"}, {"family": "Nur", "given": "Sophia A", "initials": "SA"}, {"family": "Winters", "given": "Maike", "initials": "M"}, {"family": "Bedson", "given": "Jamie", "initials": "J"}, {"family": "Pedi", "given": "Danielle", "initials": "D"}, {"family": "Prybylski", "given": "Dimitri", "initials": "D"}, {"family": "Namageyo-Funa", "given": "Apophia", "initials": "A"}, {"family": "Hageman", "given": "Kathy M", "initials": "KM"}, {"family": "Baker", "given": "Brian J", "initials": "BJ"}, {"family": "Jalloh", "given": "Mohammad B", "initials": "MB"}, {"family": "Eng", "given": "Eugenia", "initials": "E"}, {"family": "Nordenstedt", "given": "Helena", "initials": "H"}, {"family": "Hakim", "given": "Avi J", "initials": "AJ"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "issn-l": "2059-7908", "volume": "6", "issue": "1", "pages": null}, "abstract": "Human behaviour will continue to play an important role as the world grapples with public health threats. In this paper, we draw from the emerging evidence on behaviour adoption during diverse public health emergencies to develop a framework that contextualises behaviour adoption vis-\u00e0-vis a combination of top-down, intermediary and bottom-up approaches. Using the COVID-19 pandemic as a case study, we operationalise the contextual framework to demonstrate how these three approaches differ in terms of their implementation, underlying drivers of action, enforcement, reach and uptake. We illustrate how blended strategies that include all three approaches can help accelerate and sustain protective behaviours that will remain important even when safe and effective vaccines become more widely available. As the world grapples with the COVID-19 pandemic and prepares to respond to (re)emerging public health threats, our contextual framework can inform the design, implementation, tracking and evaluation of comprehensive public health and social measures during health emergencies.", "doi": "10.1136/bmjgh-2020-004450", "pmid": "33514594", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-004450"}, {"db": "pmc", "key": "PMC7849902"}], "notes": [], "created": "2021-02-04T18:43:49.858Z", "modified": "2021-06-18T08:42:50.268Z"}, {"entity": "publication", "iuid": "50d77049587b4cbca713719097ea35b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50d77049587b4cbca713719097ea35b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50d77049587b4cbca713719097ea35b1"}}, "title": "Adjuvanted SARS-CoV-2 spike protein elicits neutralizing antibodies and CD4 T cell responses after a single immunization in mice.", "authors": [{"family": "W\u00f8rzner", "given": "Katharina", "initials": "K"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Schmidt", "given": "Signe Tandrup", "initials": "ST"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Zimmermann", "given": "Julie", "initials": "J"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Christensen", "given": "Dennis", "initials": "D"}, {"family": "Pedersen", "given": "Gabriel Kristian", "initials": "GK"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": "63", "issue": null, "pages": "103197"}, "abstract": "SARS-CoV-2 has caused a global pandemic, infecting millions of people. A safe, effective vaccine is urgently needed and remains a global health priority. Subunit vaccines are used successfully against other viruses when administered in the presence of an effective adjuvant.\n\nWe evaluated three different clinically tested adjuvant systems in combination with the SARS-CoV-2 pre-fusion stabilized (S-2P) spike protein using a one-dose regimen in mice.\n\nWhilst spike protein alone was only weakly immunogenic, the addition of either Aluminum hydroxide, a squalene based oil-in-water emulsion system (SE) or a cationic liposome-based adjuvant significantly enhanced antibody responses against the spike receptor binding domain (RBD). Kinetics of antibody responses differed, with SE providing the most rapid response. Neutralizing antibodies developed after a single immunization in all adjuvanted groups with ID50 titers ranging from 86-4063. Spike-specific CD4 T helper responses were also elicited, comprising mainly of IFN-\u03b3 and IL-17 producing cells in the cationic liposome adjuvanted group, and more IL-5- and IL-10-secreting cells in the AH group.\n\nThese results demonstrate that adjuvanted spike protein subunit vaccine is a viable strategy for rapidly eliciting SARS-CoV-2 neutralizing antibodies and CD4 T cell responses of various qualities depending on the adjuvant used, which can be explored in further vaccine development against COVID-19.\n\nThis work was supported by the European Union Horizon 2020 research and innovation program under grant agreement no. 101003653.", "doi": "10.1016/j.ebiom.2020.103197", "pmid": "33422991", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Funder: H2020": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S2352-3964(20)30573-9"}, {"db": "pmc", "key": "PMC7808923"}], "notes": [], "created": "2021-02-01T14:20:38.962Z", "modified": "2021-09-27T12:30:15.492Z"}, {"entity": "publication", "iuid": "74f80925f92944c2b0a459fc6ba357b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/74f80925f92944c2b0a459fc6ba357b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/74f80925f92944c2b0a459fc6ba357b9"}}, "title": "Optimization Models for Medical Procedures Relocation", "authors": [{"family": "Nguyen", "given": "Linh Anh", "initials": "LA"}, {"family": "Sza\u0142as", "given": "Andrzej", "initials": "A"}], "type": "journal-article", "published": "2021-00-00", "journal": {"title": "Procedia Computer Science", "issn": "1877-0509", "volume": "192", "pages": "2058-2067", "issn-l": null}, "abstract": null, "doi": "10.1016/j.procs.2021.08.212", "pmid": null, "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:49:32.798Z", "modified": "2021-10-11T17:49:32.836Z"}, {"entity": "publication", "iuid": "fec3de621d134d748f62bd75b53bca7f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fec3de621d134d748f62bd75b53bca7f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fec3de621d134d748f62bd75b53bca7f"}}, "title": "High but slightly declining COVID-19 vaccine acceptance and reasons for vaccine acceptance, Finland April to December 2020\u2013Corrigendum", "authors": [{"family": "Hammer", "given": "Harlotte C", "initials": "HC"}, {"family": "Cristea", "given": "Veronica", "initials": "V"}, {"family": "Dub", "given": "Timothee", "initials": "T"}, {"family": "Sivel\u00e4", "given": "Jonas", "initials": "J"}], "type": "journal-article", "published": "2021-00-00", "journal": {"title": "Epidemiol. Infect.", "issn": "0950-2688", "issn-l": null, "volume": "149", "issue": null, "pages": null}, "abstract": null, "doi": "10.1017/s0950268821001217", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-07T05:39:16.056Z", "modified": "2021-06-18T08:31:17.891Z"}, {"entity": "publication", "iuid": "bdb24c0ca1e6408aa905b6e61a296572", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bdb24c0ca1e6408aa905b6e61a296572.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bdb24c0ca1e6408aa905b6e61a296572"}}, "title": "Cardiovascular biomarkers in patients with COVID-19", "authors": [], "type": "journal-article", "published": "2021-00-00", "journal": {"title": "European Heart Journal. Acute Cardiovascular Care", "issn": "2048-8726", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has increased awareness that severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2) may have profound effects on the cardiovascular system. COVID-19 often affects patients with pre-existing cardiac disease, and may trigger acute respiratory distress syndrome (ARDS), venous thromboembolism (VTE), acute myocardial infarction (AMI), and acute heart failure (AHF). However, as COVID-19 is primarily a respiratory infectious disease, there remain substantial uncertainty and controversy whether and how cardiovascular biomarkers should be used in patients with suspected COVID-19. To help clinicians understand the possible value as well as the most appropriate interpretation of cardiovascular biomarkers in COVID-19, it is important to highlight that recent findings regarding the prognostic role of cardiovascular biomarkers in patients hospitalized with COVID-19 are similar to those obtained in studies for pneumonia and ARDS in general. Cardiovascular biomarkers reflecting pathophysiological processes involved in COVID-19/pneumonia and its complications have a role evaluating disease severity, cardiac involvement, and risk of death in COVID-19 as well as in pneumonias caused by other pathogens. First, cardiomyocyte injury, as quantified by cardiac troponin concentrations, and haemodynamic cardiac stress, as quantified by natriuretic peptide concentrations, may occur in COVID-19 as in other pneumonias. The level of those biomarkers correlates with disease severity and mortality. Interpretation of cardiac troponin and natriuretic peptide concentrations as quantitative variables may aid in risk stratification in COVID-19/pneumonia and also will ensure that these biomarkers maintain high diagnostic accuracy for AMI and AHF. Second, activated coagulation as quantified by D-dimers seems more prominent in COVID-19 as in other pneumonias. Due to the central role of endothelitis and VTE in COVID-19, serial measurements of D-dimers may help physicians in the selection of patients for VTE imaging and the intensification of the level of anticoagulation from prophylactic to slightly higher or even therapeutic doses.", "doi": "https://doi.org/10.1093/ehjacc/zuab009", "pmid": "33655301", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-03-03T17:05:20.326Z", "modified": "2021-04-29T16:36:41.229Z"}, {"entity": "publication", "iuid": "bcc82c78df254978bd0fe5cdaa6720fe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bcc82c78df254978bd0fe5cdaa6720fe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bcc82c78df254978bd0fe5cdaa6720fe"}}, "title": "Genetic predisposition to allergic diseases is inversely associated with risk of COVID-19.", "authors": [{"family": "Larsson", "given": "Susanna C", "initials": "SC"}, {"family": "Gill", "given": "Dipender", "initials": "D"}], "type": "letter", "published": "2020-12-31", "journal": {"title": "Allergy", "issn": "1398-9995", "issn-l": "0105-4538", "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1111/all.14728", "pmid": "33382452", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-07T12:06:29.481Z", "modified": "2021-02-26T08:45:48.625Z"}, {"entity": "publication", "iuid": "6587831184184af6a1f19ec09c12c099", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6587831184184af6a1f19ec09c12c099.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6587831184184af6a1f19ec09c12c099"}}, "title": "Eco-epidemiological assessment of the COVID-19 epidemic in China, January-February 2020.", "authors": [{"family": "Byass", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2020-12-31", "journal": {"title": "Glob Health Action", "issn": "1654-9880", "issn-l": null, "volume": "13", "issue": "1", "pages": "1760490"}, "abstract": "Background: The outbreak of COVID-19 in China in early 2020 provides a rich data source for exploring the ecological determinants of this new infection, which may be of relevance as the pandemic develops.Objectives: Assessing the spread of the COVID-19 across China, in relation to associations between cases and ecological factors including population density, temperature, solar radiation and precipitation.Methods: Open-access COVID-19 case data include 18,069 geo-located cases in China during January and February 2020, which were mapped onto a 0.25\u00b0 latitude/longitude grid together with population and weather data (temperature, solar radiation and precipitation). Of 15,539 grid cells, 559 (3.6%) contained at least one case, and these were used to construct a Poisson regression model of cell-weeks. Weather parameters were taken for the preceding week given the established 5-7 day incubation period for COVID-19. The dependent variable in the Poisson model was incident cases per cell-week and exposure was cell population, allowing for clustering of cells over weeks, to give incidence rate ratios.Results: The overall COVID-19 incidence rate in cells with confirmed cases was 0.12 per 1,000. There was a single confirmed case in 113/559 (20.2%) of cells, while two grid cells recorded over 1,000 confirmed cases. Weekly means of maximum daily temperature varied from -28.0\u00b0C to 30.1\u00b0C, minimum daily temperature from -42.4\u00b0C to 23.0\u00b0C, maximum solar radiation from 0.04 to 2.74 MJm-2 and total precipitation from 0 to 72.6 mm. Adjusted incidence rate ratios suggested brighter, warmer and drier conditions were associated with lower incidence.Conclusion: Though not demonstrating cause and effect, there were appreciable associations between weather and COVID-19 incidence during the epidemic in China. This does not mean the pandemic will go away with summer weather but demonstrates the importance of using weather conditions in understanding and forecasting the spread of COVID-19.", "doi": "10.1080/16549716.2020.1760490", "pmid": "32404043", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7269037"}], "notes": [], "created": "2020-12-10T08:44:08.879Z", "modified": "2021-02-26T08:46:59.993Z"}, {"entity": "publication", "iuid": "7a40667eeaac4d1cb2751b5cb03d7639", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a40667eeaac4d1cb2751b5cb03d7639.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a40667eeaac4d1cb2751b5cb03d7639"}}, "title": "A direct RT-qPCR approach to test large numbers of individuals for SARS-CoV-2.", "authors": [{"family": "Maricic", "given": "Tomislav", "initials": "T"}, {"family": "Nickel", "given": "Olaf", "initials": "O"}, {"family": "Aximu-Petri", "given": "Ayinuer", "initials": "A"}, {"family": "Essel", "given": "Elena", "initials": "E"}, {"family": "Gansauge", "given": "Marie", "initials": "M"}, {"family": "Kanis", "given": "Philipp", "initials": "P"}, {"family": "Macak", "given": "Dominik", "initials": "D"}, {"family": "Richter", "given": "Julia", "initials": "J"}, {"family": "Riesenberg", "given": "Stephan", "initials": "S"}, {"family": "Bokelmann", "given": "Lukas", "initials": "L"}, {"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "Meyer", "given": "Matthias", "initials": "M"}, {"family": "Borte", "given": "Stephan", "initials": "S"}, {"family": "P\u00e4\u00e4bo", "given": "Svante", "initials": "S"}], "type": "journal article", "published": "2020-12-31", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "15", "issue": "12", "pages": "e0244824", "issn-l": "1932-6203"}, "abstract": "SARS-CoV-2 causes substantial morbidity and mortality in elderly and immunocompromised individuals, particularly in retirement homes, where transmission from asymptomatic staff and visitors may introduce the infection. Here we present a cheap and fast screening method based on direct RT-qPCR to detect SARS-CoV-2 in single or pooled gargle lavages (\"mouthwashes\"). This method detects individuals with large viral loads (Ct\u226429) and we use it to test all staff at a nursing home daily over a period of three weeks in order to reduce the risk that the infection penetrates the facility. This or similar approaches can be implemented to protect hospitals, nursing homes and other institutions in this and future viral epidemics.", "doi": "10.1371/journal.pone.0244824", "pmid": "33382830", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0244824#sec013", "description": "All data are available in the supplementary information"}], "notes": [], "created": "2021-01-07T11:53:04.600Z", "modified": "2021-11-18T12:42:52.436Z"}, {"entity": "publication", "iuid": "f15874bd4c424661b8db73c43a1afd31", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f15874bd4c424661b8db73c43a1afd31.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f15874bd4c424661b8db73c43a1afd31"}}, "title": "Time Trends of the Public\u2019s Attention Toward Suicide During the COVID-19 Pandemic: Retrospective, Longitudinal Time-Series Study", "authors": [{"family": "Burnett", "given": "Dayle", "initials": "D"}, {"family": "Eapen", "given": "Valsamma", "initials": "V"}, {"family": "Lin", "given": "Ping I", "initials": "PI"}], "type": "journal-article", "published": "2020-12-30", "journal": {"title": "JMIR Public Health Surveill", "issn": "2369-2960", "volume": "6", "issue": "4", "pages": "e24694", "issn-l": null}, "abstract": null, "doi": "10.2196/24694", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-10T18:13:57.524Z", "modified": "2021-02-26T08:47:00.305Z"}, {"entity": "publication", "iuid": "95a37cbd41734367bc2b23e615569b9f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95a37cbd41734367bc2b23e615569b9f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95a37cbd41734367bc2b23e615569b9f"}}, "title": "Integrating the social sciences in epidemic preparedness and response: A strategic framework to strengthen capacities and improve Global Health security.", "authors": [{"family": "Bardosh", "given": "Kevin Louis", "initials": "KL"}, {"family": "de Vries", "given": "Daniel H", "initials": "DH"}, {"family": "Abramowitz", "given": "Sharon", "initials": "S"}, {"family": "Thorlie", "given": "Adama", "initials": "A"}, {"family": "Cremers", "given": "Lianne", "initials": "L"}, {"family": "Kinsman", "given": "John", "initials": "J"}, {"family": "Stellmach", "given": "Darryl", "initials": "D"}], "type": "journal article", "published": "2020-12-30", "journal": {"title": "Global Health", "issn": "1744-8603", "volume": "16", "issue": "1", "pages": "120", "issn-l": "1744-8603"}, "abstract": "The importance of integrating the social sciences in epidemic preparedness and response has become a common feature of infectious disease policy and practice debates. However to date, this integration remains inadequate, fragmented and under-funded, with limited reach and small initial investments. Based on data collected prior to the COVID-19 pandemic, in this paper we analysed the variety of knowledge, infrastructure and funding gaps that hinder the full integration of the social sciences in epidemics and present a strategic framework for addressing them.\n\nSenior social scientists with expertise in public health emergencies facilitated expert deliberations, and conducted 75 key informant interviews, a consultation with 20 expert social scientists from Africa, Asia and Europe, 2 focus groups and a literature review of 128 identified high-priority peer reviewed articles. We also analysed 56 interviews from the Ebola 100 project, collected just after the West African Ebola epidemic. Analysis was conducted on gaps and recommendations. These were inductively classified according to various themes during two group prioritization exercises. The project was conducted between February and May 2019. Findings from the report were used to inform strategic prioritization of global investments in social science capacities for health emergencies.\n\nOur analysis consolidated 12 knowledge and infrastructure gaps and 38 recommendations from an initial list of 600 gaps and 220 recommendations. In developing our framework, we clustered these into three areas: 1) Recommendations to improve core social science response capacities, including investments in: human resources within response agencies; the creation of social science data analysis capacities at field and global level; mechanisms for operationalizing knowledge; and a set of rapid deployment infrastructures; 2) Recommendations to strengthen applied and basic social sciences, including the need to: better define the social science agenda and core competencies; support innovative interdisciplinary science; make concerted investments in developing field ready tools and building the evidence-base; and develop codes of conduct; and 3) Recommendations for a supportive social science ecosystem, including: the essential foundational investments in institutional development; training and capacity building; awareness-raising activities with allied disciplines; and lastly, support for a community of practice.\n\nComprehensively integrating social science into the epidemic preparedness and response architecture demands multifaceted investments on par with allied disciplines, such as epidemiology and virology. Building core capacities and competencies should occur at multiple levels, grounded in country-led capacity building. Social science should not be a parallel system, nor should it be \"siloed\" into risk communication and community engagement. Rather, it should be integrated across existing systems and networks, and deploy interdisciplinary knowledge \"transversally\" across all preparedness and response sectors and pillars. Future work should update this framework to account for the impact of the COVID-19 pandemic on the institutional landscape.", "doi": "10.1186/s12992-020-00652-6", "pmid": "33380341", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12992-020-00652-6"}, {"db": "pmc", "key": "PMC7772799"}], "notes": [], "created": "2021-01-07T12:10:19.942Z", "modified": "2021-02-26T08:47:00.083Z"}, {"entity": "publication", "iuid": "af36f6a1c29d4c64bd3c8e3c58546657", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/af36f6a1c29d4c64bd3c8e3c58546657.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/af36f6a1c29d4c64bd3c8e3c58546657"}}, "title": "COVID-19 spatiotemporal research with workflow-based data analysis.", "authors": [{"family": "Chintala", "given": "Srikar", "initials": "S"}, {"family": "Dutta", "given": "Ritvik", "initials": "R"}, {"family": "Tadmor", "given": "Doron", "initials": "D"}], "type": "journal article", "published": "2020-12-30", "journal": {"title": "Infect Genet Evol", "issn": "1567-7257", "volume": null, "issue": null, "pages": "104701", "issn-l": null}, "abstract": "Given the pertinence and acceleration of the spread of COVID-19, there is an increased need for the replicability of data models to verify the veracity of models and visualize important data. Most of these visualizations lack reproducibility, credibility, or accuracy, and are static, which makes it difficult to analyze the spread over time. Furthermore, most current visualizations depicting the spread of COVID-19 are at a global or country level, meaning there is a dearth of regional analysis within a country. Keeping these issues in mind, a replicable, efficient, and simple method to generate regional COVID-19 visualizations mapped with time was created by using the KNIME software, an open-source data analytics platform that can create user-friendly applications or workflows. For this analysis, Albania, Sweden, Ukraine, Denmark, Russia, India, and Australia were closely observed. Among the maps generated for the aforementioned countries, it was noticed that regions with a high population or high population density were often the epicenters within their respective country. The regions caused the virus to spread to their neighboring regions: kickstarting the \"domino effect\", leading to the infection of another region until the country is overwhelmed with cases-what we call a proximity trend. These dynamic maps are crucial to fighting the pandemic because they can provide insight as to how COVID-19 spreads by providing researchers or officials with an accurate and insightful tool to aid their analysis. By being able to visualize the spread, health and government officials can dive deeper to identify the sources of transmission and attempt to stop or reverse them accordingly.", "doi": "10.1016/j.meegid.2020.104701", "pmid": "33387692", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S1567-1348(20)30532-3"}, {"db": "pmc", "key": "PMC7773529"}], "notes": [], "created": "2021-01-07T11:21:45.756Z", "modified": "2021-02-26T08:46:13.433Z"}, {"entity": "publication", "iuid": "2b3f61fe73ac49f0b91cc6fc002bcc7c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b3f61fe73ac49f0b91cc6fc002bcc7c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b3f61fe73ac49f0b91cc6fc002bcc7c"}}, "title": "ACE2: the molecular doorway to SARS-CoV-2.", "authors": [{"family": "Medina-Enr\u00edquez", "given": "Miriam Marlene", "initials": "MM"}, {"family": "Lopez-Le\u00f3n", "given": "Sandra", "initials": "S"}, {"family": "Carlos-Escalante", "given": "Jos\u00e9 Alberto", "initials": "JA"}, {"family": "Aponte-Torres", "given": "Zuleika", "initials": "Z"}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Wegman-Ostrosky", "given": "Talia", "initials": "T"}], "type": "journal article", "published": "2020-12-30", "journal": {"title": "Cell Biosci", "issn": "2045-3701", "volume": "10", "issue": "1", "pages": "148", "issn-l": null}, "abstract": "The angiotensin-converting enzyme 2 (ACE2) is the host functional receptor for the new virus SARS-CoV-2 causing Coronavirus Disease 2019. ACE2 is expressed in 72 different cell types. Some factors that can affect the expression of the ACE2 are: sex, environment, comorbidities, medications (e.g. anti-hypertensives) and its interaction with other genes of the renin-angiotensin system and other pathways. Different factors can affect the risk of infection of SARS-CoV-2 and determine the severity of the symptoms. The ACE2 enzyme is a negative regulator of RAS expressed in various organ systems. It is with immunity, inflammation, increased coagulopathy, and cardiovascular disease. In this review, we describe the genetic and molecular functions of the ACE2 receptor and its relation with the physiological and pathological conditions to better understand how this receptor is involved in the pathogenesis of COVID-19. In addition, it reviews the different comorbidities that interact with SARS-CoV-2 in which also ACE2 plays an important role. It also describes the different factors that interact with the virus that have an influence in the expression and functional activities of the receptor. The goal is to provide the reader with an understanding of the complexity and importance of this receptor.", "doi": "10.1186/s13578-020-00519-8", "pmid": "33380340", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13578-020-00519-8"}, {"db": "pmc", "key": "PMC7772801"}], "notes": [], "created": "2021-01-07T12:14:04.788Z", "modified": "2021-01-07T12:14:04.810Z"}, {"entity": "publication", "iuid": "881a0630ec5d4fc8bfdd76a818723b0c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/881a0630ec5d4fc8bfdd76a818723b0c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/881a0630ec5d4fc8bfdd76a818723b0c"}}, "title": "Plasma renin activity has a complex prognostic role in patients with acute coronary syndromes.", "authors": [{"family": "Hartford", "given": "Marianne", "initials": "M"}, {"family": "Herlitz", "given": "Hans", "initials": "H"}, {"family": "Perers", "given": "Elisabeth", "initials": "E"}, {"family": "Karlsson", "given": "Thomas", "initials": "T"}, {"family": "Herlitz", "given": "Johan", "initials": "J"}, {"family": "Persson", "given": "Anita", "initials": "A"}, {"family": "Caidahl", "given": "Kenneth", "initials": "K"}], "type": "journal article", "published": "2020-12-29", "journal": {"title": "Int J Cardiol", "issn": "1874-1754", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Plasma renin activity (PRA) has been related to all-cause mortality and cardiovascular events in patients with cardiovascular disease. However, data from patients with acute coronary syndromes (ACS) are sparse.\r\n\r\nDetermination of PRA was made in 550 patients with ACS, including a subgroup of 287 patients not on treatment with angiotensin converting enzyme inhibitors, angiotensin receptor blockers or diuretics, and without heart failure. We evaluated the relations between PRA and all-cause mortality after three years and long-term, and to cardiovascular events after median 8.7 years. Adjustments were made for variables that influenced the hazard ratio (HR) > 5% for the relation between PRA and outcome.\r\n\r\nBaseline PRA was associated with all-cause mortality during three-years (unadjusted HR 1.74 per 1 SD increase in logarithmically transformed PRA; 95% confidence interval (CI) 1.39-2.16, p < 0.0001) and long-term (HR 1.12, CI 1.00-1.25, p = 0.046). After adjustments, only the three-year association remained significant. In unadjusted analyses, PRA was associated with cardiovascular death, but not with nonfatal cardiovascular events. In the subgroup there was an inverse relation between PRA and long-term all-cause mortality.\r\n\r\nHigher PRA was a significant independent predictor of all-cause mortality after three years, but not at long-term follow-up and not significantly associated with cardiovascular incidence. The renin-angiotensin-system pathophysiology is of great interest, not least due to its association with the COVID-19 pandemic. Our findings indicate a need for further research on the prognostic/predictive aspects of the renin-angiotensin-system in ACS.", "doi": "10.1016/j.ijcard.2020.12.062", "pmid": "33385419", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0167-5273(20)34310-2"}], "notes": [], "created": "2021-01-07T11:37:34.979Z", "modified": "2021-02-26T08:45:48.437Z"}, {"entity": "publication", "iuid": "7d408a34c8ea4368a9fa5d59d4194de1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d408a34c8ea4368a9fa5d59d4194de1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d408a34c8ea4368a9fa5d59d4194de1"}}, "title": "Paediatricians face challenging times as COVID\u201019 can cloud other diagnoses and lead to treatment delays", "authors": [{"family": "Marits", "given": "Ann Katrine", "initials": "AK"}, {"family": "Fischler", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Chromek", "given": "Milan", "initials": "M"}], "type": "journal-article", "published": "2020-12-29", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1111/apa.15725", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-08T09:09:04.389Z", "modified": "2021-02-26T08:45:48.390Z"}, {"entity": "publication", "iuid": "9981ed7c4c3f402ea9ae9ebd7df56738", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9981ed7c4c3f402ea9ae9ebd7df56738.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9981ed7c4c3f402ea9ae9ebd7df56738"}}, "title": "Broadly Active Antiviral Compounds Disturb Zika Virus Progeny Release Rescuing Virus-Induced Toxicity in Brain Organoids.", "authors": [{"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Tampere", "given": "Marianna", "initials": "M"}, {"family": "Pronk", "given": "Robin", "initials": "R"}, {"family": "Wallner", "given": "Olov", "initials": "O"}, {"family": "Falk", "given": "Anna", "initials": "A"}, {"family": "Warpman Berglund", "given": "Ulrika", "initials": "U"}, {"family": "Helleday", "given": "Thomas", "initials": "T"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Puumalainen", "given": "Marjo-Riitta", "initials": "MR"}], "type": "journal article", "published": "2020-12-29", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "1", "pages": "37", "issn-l": "1999-4915"}, "abstract": "RNA viruses have gained plenty of attention during recent outbreaks of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Zika virus (ZIKV), and Ebola virus. ZIKV is a vector borne Flavivirus that is spread by mosquitoes and it mainly infects neuronal progenitor cells. One hallmark of congenital ZIKV disease is a reduced brain size in fetuses, leading to severe neurological defects. The World Health Organization (WHO) is urging the development of new antiviral treatments against ZIKV, as there are no efficient countermeasures against ZIKV disease. Previously, we presented a new class of host-targeting antivirals active against a number of pathogenic RNA viruses, such as SARS-CoV-2. Here, we show the transfer of the image-based phenotypic antiviral assay to ZIKV-infected brain cells, followed by mechanism-of-action studies and a proof-of-concept study in a three-dimensional (3D) organoid model. The novel antiviral compounds showed a therapeutic window against ZIKV in several cell models and rescued ZIKV-induced neurotoxicity in brain organoids. The compound's mechanism-of-action was pinpointed to late steps in the virus life cycle, impairing the formation of new virus particles. Collectively, in this study, we expand the antiviral activity of new small molecule inhibitors to a new virus class of Flaviviruses, but also uncover compounds' mechanism of action, which are important for the further development of antivirals.", "doi": "10.3390/v13010037", "pmid": "33383826", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: H2020": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "v13010037"}, {"db": "URL", "key": "https://www.mdpi.com/1999-4915/13/1/37/s1", "description": "The effect of novel antiviral compounds against ZIKV in several cell models; other supporting data"}], "notes": [], "created": "2021-01-07T11:49:35.800Z", "modified": "2021-02-26T08:45:03.173Z"}, {"entity": "publication", "iuid": "e990290ae5f6422b9b724ae8ee6e58e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e990290ae5f6422b9b724ae8ee6e58e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e990290ae5f6422b9b724ae8ee6e58e1"}}, "title": "Seropositivity in blood donors and pregnant women during 9-months of SARS-CoV-2 transmission in Stockholm, Sweden", "authors": [{"family": "Dopico", "given": "Xaquin Castro", "initials": "XC"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Christian", "given": "Murray", "initials": "M"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Grinberg", "given": "Nastasiya F", "initials": "NF"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Mcinerney", "given": "Gerald M", "initials": "GM"}, {"family": "Allander", "given": "Tobias", "initials": "T"}, {"family": "Wallace", "given": "Chris", "initials": "C"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}], "type": "posted-content", "published": "2020-12-26", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.24.20248821", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Funder: H2020": null, "Category: Health": null, "Category: Serology": null}, "xrefs": [{"db": "URL", "key": "https://github.com/MurrellGroup/DiscriminativeSeroprevalence/", "description": "Data and analysis code (Ben Murrell Group)"}, {"db": "URL", "key": "https://github.com/chr1swallace/seroprevalence-paper", "description": "Data and analysis code (Chris Wallace Group)"}], "notes": [], "created": "2021-01-07T16:43:04.878Z", "modified": "2021-04-23T09:09:33.692Z"}, {"entity": "publication", "iuid": "3aeb13b25a9d4e3da6ffa6db5a446fe7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3aeb13b25a9d4e3da6ffa6db5a446fe7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3aeb13b25a9d4e3da6ffa6db5a446fe7"}}, "title": "Adverse effects of hydroxychloroquine and azithromycin on contractility and arrhythmogenicity revealed by human engineered cardiac tissues.", "authors": [{"family": "Wong", "given": "Andy On-Tik", "initials": "AO"}, {"family": "Gurung", "given": "Bimal", "initials": "B"}, {"family": "Wong", "given": "Wing Sum", "initials": "WS"}, {"family": "Mak", "given": "Suet Yee", "initials": "SY"}, {"family": "Tse", "given": "Wan Wai", "initials": "WW"}, {"family": "Li", "given": "Chloe M", "initials": "CM"}, {"family": "Lieu", "given": "Deborah K", "initials": "DK"}, {"family": "Costa", "given": "Kevin D", "initials": "KD"}, {"family": "Li", "given": "Ronald A", "initials": "RA"}, {"family": "Hajjar", "given": "Roger J", "initials": "RJ"}], "type": "journal article", "published": "2020-12-26", "journal": {"title": "J Mol Cell Cardiol", "issn": "1095-8584", "volume": "153", "issue": null, "pages": "106-110", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic as declared by World Health Organization (WHO). In the absence of an effective treatment in early 2020, different drugs with unknown effectiveness, including antimalarial hydroxychloroquine (HCQ), with or without concurrent administration with azithromycin (AZM), have been tested for treating COVID-19 patients with developed pneumonia. However, the efficacy and safety of HCQ and/or AZM have been questioned by recent clinical reports. Direct effects of these drugs on the human heart remain very poorly defined. To better understand the mechanisms of action of HCQ +/- AZM, we employed bioengineered human ventricular cardiac tissue strip (hvCTS) and anisotropic sheet (hvCAS) assays, made with human pluripotent stem cell (hPSC)-derived ventricular cardiomyocytes (hvCMs), which have been designed for measuring cardiac contractility and electrophysiology, respectively. Our hvCTS experiments showed that AZM induced a dose-dependent negative inotropic effect which could be aggravated by HCQ; electrophysiologically, as revealed by the hvCAS platform, AZM prolonged action potentials and induced spiral wave formations. Collectively, our data were consistent with reported clinical risks of HCQ and AZM on QTc prolongation/ventricular arrhythmias and development of heart failure. In conclusion, our study exposed the risks of HCQ/AZM administration while providing mechanistic insights for their toxicity. Our bioengineered human cardiac tissue constructs therefore provide a useful platform for screening cardiac safety and efficacy when developing therapeutics against COVID-19.", "doi": "10.1016/j.yjmcc.2020.12.014", "pmid": "33373642", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S0022-2828(20)30354-0"}, {"db": "pmc", "key": "PMC7765761"}], "notes": [], "created": "2021-01-07T12:32:02.760Z", "modified": "2021-02-26T08:45:25.850Z"}, {"entity": "publication", "iuid": "13a67022e71646239744a33435e1b112", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13a67022e71646239744a33435e1b112.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13a67022e71646239744a33435e1b112"}}, "title": "Risk of depression, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: a multinational network cohort study.", "authors": [{"family": "Lane", "given": "Jennifer C E", "initials": "JCE"}, {"family": "Weaver", "given": "James", "initials": "J"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "Abrahao", "given": "Maria Tereza F", "initials": "MTF"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Biedermann", "given": "Patricia", "initials": "P"}, {"family": "Banda", "given": "Juan M", "initials": "JM"}, {"family": "Burn", "given": "Edward", "initials": "E"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "Fister", "given": "Kristina", "initials": "K"}, {"family": "Hardin", "given": "Jill", "initials": "J"}, {"family": "Hester", "given": "Laura", "initials": "L"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Kaas-Hansen", "given": "Benjamin Skov", "initials": "BS"}, {"family": "Khosla", "given": "Sajan", "initials": "S"}, {"family": "Kolovos", "given": "Spyros", "initials": "S"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Makadia", "given": "Rupa", "initials": "R"}, {"family": "Mehta", "given": "Paras P", "initials": "PP"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Morgan-Stewart", "given": "Henry", "initials": "H"}, {"family": "Mosseveld", "given": "Mees", "initials": "M"}, {"family": "Newby", "given": "Danielle", "initials": "D"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Woong Park", "given": "Rae", "initials": "R"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A"}, {"family": "Rao", "given": "Gowtham A", "initials": "GA"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Rijnbeek", "given": "Peter", "initials": "P"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Shoaibi", "given": "Azza", "initials": "A"}, {"family": "Spotnitz", "given": "Matthew", "initials": "M"}, {"family": "Vignesh", "given": "Subbian", "initials": "S"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Vizcaya", "given": "David", "initials": "D"}, {"family": "Wen", "given": "Haini", "initials": "H"}, {"family": "de Wilde", "given": "Marcel", "initials": "M"}, {"family": "Xie", "given": "Junqing", "initials": "J"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Lovestone", "given": "Simon", "initials": "S"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "OHDSI-COVID-19 consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2020-12-25", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "volume": null, "issue": null, "issn-l": null}, "abstract": "Concern has been raised in the rheumatology community regarding recent regulatory warnings that HCQ used in the coronavirus disease 2019 pandemic could cause acute psychiatric events. We aimed to study whether there is risk of incident depression, suicidal ideation or psychosis associated with HCQ as used for RA.\n\nWe performed a new-user cohort study using claims and electronic medical records from 10 sources and 3 countries (Germany, UK and USA). RA patients \u226518 years of age and initiating HCQ were compared with those initiating SSZ (active comparator) and followed up in the short (30 days) and long term (on treatment). Study outcomes included depression, suicide/suicidal ideation and hospitalization for psychosis. Propensity score stratification and calibration using negative control outcomes were used to address confounding. Cox models were fitted to estimate database-specific calibrated hazard ratios (HRs), with estimates pooled where I2 <40%.\n\nA total of 918 144 and 290 383 users of HCQ and SSZ, respectively, were included. No consistent risk of psychiatric events was observed with short-term HCQ (compared with SSZ) use, with meta-analytic HRs of 0.96 (95% CI 0.79, 1.16) for depression, 0.94 (95% CI 0.49, 1.77) for suicide/suicidal ideation and 1.03 (95% CI 0.66, 1.60) for psychosis. No consistent long-term risk was seen, with meta-analytic HRs of 0.94 (95% CI 0.71, 1.26) for depression, 0.77 (95% CI 0.56, 1.07) for suicide/suicidal ideation and 0.99 (95% CI 0.72, 1.35) for psychosis.\n\nHCQ as used to treat RA does not appear to increase the risk of depression, suicide/suicidal ideation or psychosis compared with SSZ. No effects were seen in the short or long term. Use at a higher dose or for different indications needs further investigation.\n\nRegistered with EU PAS (reference no. EUPAS34497; http://www.encepp.eu/encepp/viewResource.htm? id=34498). The full study protocol and analysis source code can be found at https://github.com/ohdsi-studies/Covid19EstimationHydroxychloroquine2.", "doi": "10.1093/rheumatology/keaa771", "pmid": "33367863", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://github.com/ohdsi-studies/Covid19EstimationHydroxychloroquine2", "description": "Data aggregated by data source"}], "notes": [], "created": "2021-01-07T13:36:58.823Z", "modified": "2021-04-26T17:59:42.486Z"}, {"entity": "publication", "iuid": "6add60296d9a47959698548642400e61", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6add60296d9a47959698548642400e61.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6add60296d9a47959698548642400e61"}}, "title": "Recent smell loss is the best predictor of COVID-19 among individuals with recent respiratory symptoms", "authors": [{"family": "Gerkin", "given": "Richard C", "initials": "RC"}, {"family": "Ohla", "given": "Kathrin", "initials": "K"}, {"family": "Veldhuizen", "given": "Maria G", "initials": "MG"}, {"family": "Joseph", "given": "Paule V", "initials": "PV"}, {"family": "Kelly", "given": "Christine E", "initials": "CE"}, {"family": "Bakke", "given": "Alyssa J", "initials": "AJ"}, {"family": "Steele", "given": "Kimberley E", "initials": "KE"}, {"family": "Farruggia", "given": "Michael C", "initials": "MC"}, {"family": "Pellegrino", "given": "Robert", "initials": "R"}, {"family": "Pepino", "given": "Marta Y", "initials": "MY"}, {"family": "Bouysset", "given": "C\u00e9dric", "initials": "C"}, {"family": "Soler", "given": "Graciela M", "initials": "GM"}, {"family": "Pereda-Loth", "given": "Veronica", "initials": "V"}, {"family": "Dibattista", "given": "Michele", "initials": "M"}, {"family": "Cooper", "given": "Keiland W", "initials": "KW"}, {"family": "Croijmans", "given": "Ilja", "initials": "I"}, {"family": "Di Pizio", "given": "Antonella", "initials": "A"}, {"family": "Ozdener", "given": "M Hakan", "initials": "MH"}, {"family": "Fjaeldstad", "given": "Alexander W", "initials": "AW"}, {"family": "Lin", "given": "Cailu", "initials": "C"}, {"family": "Sandell", "given": "Mari A", "initials": "MA"}, {"family": "Singh", "given": "Preet B", "initials": "PB"}, {"family": "Brindha", "given": "V Evelyn", "initials": "VE"}, {"family": "Olsson", "given": "Shannon B", "initials": "SB"}, {"family": "Saraiva", "given": "Luis R", "initials": "LR"}, {"family": "Ahuja", "given": "Gaurav", "initials": "G"}, {"family": "Alwashahi", "given": "Mohammed K", "initials": "MK"}, {"family": "Bhutani", "given": "Surabhi", "initials": "S"}, {"family": "D\u2019Errico", "given": "Anna", "initials": "A"}, {"family": "Fornazieri", "given": "Marco A", "initials": "MA"}, {"family": "Golebiowski", "given": "J\u00e9r\u00f4me", "initials": "J"}, {"family": "Hwang", "given": "Liang Dar", "initials": "LD"}, {"family": "\u00d6zt\u00fcrk", "given": "Lina", "initials": "L"}, {"family": "Roura", "given": "Eugeni", "initials": "E"}, {"family": "Spinelli", "given": "Sara", "initials": "S"}, {"family": "Whitcroft", "given": "Katherine L", "initials": "KL"}, {"family": "Faraji", "given": "Farhoud", "initials": "F"}, {"family": "Fischmeister", "given": "Florian PhS", "initials": "FP"}, {"family": "Heinbockel", "given": "Thomas", "initials": "T"}, {"family": "Hsieh", "given": "Julien W", "initials": "JW"}, {"family": "Huart", "given": "Caroline", "initials": "C"}, {"family": "Konstantinidis", "given": "Iordanis", "initials": "I"}, {"family": "Menini", "given": "Anna", "initials": "A"}, {"family": "Morini", "given": "Gabriella", "initials": "G"}, {"family": "Olofsson", "given": "Jonas K", "initials": "JK"}, {"family": "Philpott", "given": "Carl M", "initials": "CM"}, {"family": "Pierron", "given": "Denis", "initials": "D"}, {"family": "Shields", "given": "Vonnie D C", "initials": "VDC"}, {"family": "Voznessenskaya", "given": "Vera V", "initials": "VV"}, {"family": "Albayay", "given": "Javier", "initials": "J"}, {"family": "Altundag", "given": "Aytug", "initials": "A"}, {"family": "Bensafi", "given": "Moustafa", "initials": "M"}, {"family": "Bock", "given": "Mar\u00eda Adelaida", "initials": "MA"}, {"family": "Calcinoni", "given": "Orietta", "initials": "O"}, {"family": "Fredborg", "given": "William", "initials": "W"}, {"family": "Laudamiel", "given": "Christophe", "initials": "C"}, {"family": "Lim", "given": "Juyun", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Johan N", "initials": "JN"}, {"family": "Macchi", "given": "Alberto", "initials": "A"}, {"family": "Meyer", "given": "Pablo", "initials": "P"}, {"family": "Moein", "given": "Shima T", "initials": "ST"}, {"family": "Santamar\u00eda", "given": "Enrique", "initials": "E"}, {"family": "Sengupta", "given": "Debarka", "initials": "D"}, {"family": "Dominguez", "given": "Paloma Rohlfs", "initials": "PR"}, {"family": "Yanik", "given": "H\u00fcseyin", "initials": "H"}, {"family": "Hummel", "given": "Thomas", "initials": "T"}, {"family": "Hayes", "given": "John E", "initials": "JE"}, {"family": "Reed", "given": "Danielle R", "initials": "DR"}, {"family": "Niv", "given": "Masha Y", "initials": "MY"}, {"family": "Munger", "given": "Steven D", "initials": "SD"}, {"family": "Parma", "given": "Valentina", "initials": "V"}, {"family": "Boesveldt", "given": "Sanne", "initials": "S"}, {"family": "de Groot", "given": "Jasper H B", "initials": "JHB"}, {"family": "Dinnella", "given": "Caterina", "initials": "C"}, {"family": "Freiherr", "given": "Jessica", "initials": "J"}, {"family": "Laktionova", "given": "Tatiana", "initials": "T"}, {"family": "Marino", "given": "Sajidxa", "initials": "S"}, {"family": "Monteleone", "given": "Erminio", "initials": "E"}, {"family": "Nunez-Parra", "given": "Alexia", "initials": "A"}, {"family": "Abdulrahman", "given": "Olagunju", "initials": "O"}, {"family": "Ritchie", "given": "Marina", "initials": "M"}, {"family": "Thomas-Danguin", "given": "Thierry", "initials": "T"}, {"family": "Walsh-Messinger", "given": "Julie", "initials": "J"}, {"family": "Al Abri", "given": "Rashid", "initials": "R"}, {"family": "Alizadeh", "given": "Rafieh", "initials": "R"}, {"family": "Bignon", "given": "Emmanuelle", "initials": "E"}, {"family": "Cantone", "given": "Elena", "initials": "E"}, {"family": "Cecchini", "given": "Maria Paola", "initials": "MP"}, {"family": "Chen", "given": "Jingguo", "initials": "J"}, {"family": "Gu\u00e0rdia", "given": "Maria Dolors", "initials": "MD"}, {"family": "Hoover", "given": "Kara C", "initials": "KC"}, {"family": "Karni", "given": "Noam", "initials": "N"}, {"family": "Navarro", "given": "Marta", "initials": "M"}, {"family": "Nolden", "given": "Alissa A", "initials": "AA"}, {"family": "Mazal", "given": "Patricia Portillo", "initials": "PP"}, {"family": "Rowan", "given": "Nicholas R", "initials": "NR"}, {"family": "Sarabi-Jamab", "given": "Atiye", "initials": "A"}, {"family": "Archer", "given": "Nicholas S", "initials": "NS"}, {"family": "Chen", "given": "Ben", "initials": "B"}, {"family": "Di Valerio", "given": "Elizabeth A", "initials": "EA"}, {"family": "Feeney", "given": "Emma L", "initials": "EL"}, {"family": "Frasnelli", "given": "Johannes", "initials": "J"}, {"family": "Hannum", "given": "Mackenzie E", "initials": "ME"}, {"family": "Hopkins", "given": "Claire", "initials": "C"}, {"family": "Klein", "given": "Hadar", "initials": "H"}, {"family": "Mignot", "given": "Coralie", "initials": "C"}, {"family": "Mucignat", "given": "Carla", "initials": "C"}, {"family": "Ning", "given": "Yuping", "initials": "Y"}, {"family": "Ozturk", "given": "Elif E", "initials": "EE"}, {"family": "Peng", "given": "Mei", "initials": "M"}, {"family": "Saatci", "given": "Ozlem", "initials": "O"}, {"family": "Sell", "given": "Elizabeth A", "initials": "EA"}, {"family": "Yan", "given": "Carol H", "initials": "CH"}, {"family": "Alfaro", "given": "Raul", "initials": "R"}, {"family": "Cecchetto", "given": "Cinzia", "initials": "C"}, {"family": "Coureaud", "given": "G\u00e9rard", "initials": "G"}, {"family": "Herriman", "given": "Riley D", "initials": "RD"}, {"family": "Justice", "given": "Jeb M", "initials": "JM"}, {"family": "Kaushik", "given": "Pavan Kumar", "initials": "PK"}, {"family": "Koyama", "given": "Sachiko", "initials": "S"}, {"family": "Overdevest", "given": "Jonathan B", "initials": "JB"}, {"family": "Pirastu", "given": "Nicola", "initials": "N"}, {"family": "Ramirez", "given": "Vicente A", "initials": "VA"}, {"family": "Roberts", "given": "S Craig", "initials": "SC"}, {"family": "Smith", "given": "Barry C", "initials": "BC"}, {"family": "Cao", "given": "Hongyuan", "initials": "H"}, {"family": "Wang", "given": "Hong", "initials": "H"}, {"family": "Birindwa", "given": "Patrick Balungwe", "initials": "PB"}, {"family": "Baguma", "given": "Marius", "initials": "M"}, {"family": null, "given": "", "initials": ""}], "type": "journal-article", "published": "2020-12-25", "journal": {"title": "Chem Senses", "issn": "0379-864X", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1093/chemse/bjaa081", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-07T13:27:02.579Z", "modified": "2021-02-26T08:45:48.282Z"}, {"entity": "publication", "iuid": "58d80771ef804c749a527a139bb4267e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/58d80771ef804c749a527a139bb4267e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/58d80771ef804c749a527a139bb4267e"}}, "title": "Practical recommendations for the management of patients with gastroenteropancreatic and thoracic (carcinoid) neuroendocrine neoplasms in the COVID-19 era.", "authors": [{"family": "Rodriguez-Freixinos", "given": "V\u00edctor", "initials": "V"}, {"family": "Capdevila", "given": "Jaume", "initials": "J"}, {"family": "Pavel", "given": "Marianne", "initials": "M"}, {"family": "Thawer", "given": "Alia", "initials": "A"}, {"family": "Baudin", "given": "Eric", "initials": "E"}, {"family": "O'Toole", "given": "Dermot", "initials": "D"}, {"family": "Herrmann", "given": "Ken", "initials": "K"}, {"family": "Welin", "given": "Staffan", "initials": "S"}, {"family": "Grozinsky-Glasberg", "given": "Simona", "initials": "S"}, {"family": "de Herder", "given": "Wouter W", "initials": "WW"}, {"family": "Valle", "given": "Juan W", "initials": "JW"}, {"family": "Herman", "given": "Jackie", "initials": "J"}, {"family": "Kolarova", "given": "Teodora", "initials": "T"}, {"family": "Bouvier", "given": "Catherine", "initials": "C"}, {"family": "Falconi", "given": "Massimo", "initials": "M"}, {"family": "Ferone", "given": "Diego", "initials": "D"}, {"family": "Singh", "given": "Simron", "initials": "S"}], "type": "journal article", "published": "2020-12-25", "journal": {"title": "Eur J Cancer", "issn": "1879-0852", "volume": "144", "issue": null, "pages": "200-214", "issn-l": "0959-8049"}, "abstract": "Neuroendocrine neoplasms (NENs) are a heterogeneous family of uncommon tumours with challenging diagnosis, clinical management and unique needs that almost always requires a multidisciplinary approach. In the absence of guidance from the scientific literature, along with the rapidly changing data available on the effect of COVID-19, we report how 12 high-volume NEN centres of expertise in 10 countries at different stages of the evolving COVID-19 global pandemic along with members of international neuroendocrine cancer patient societies have suggested to preserve high standards of care for patients with NENs. We review the multidisciplinary management of neuroendocrine neoplasms during the COVID-19 pandemic, and we suggest potential strategies to reduce risk and aid multidisciplinary treatment decision-making. By sharing our joint experiences, we aim to generate recommendations for proceeding to other institutions facing the same challenges.", "doi": "10.1016/j.ejca.2020.11.037", "pmid": "33370645", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0959-8049(20)31374-5"}], "notes": [], "created": "2021-01-07T13:13:58.912Z", "modified": "2021-01-07T13:13:58.922Z"}, {"entity": "publication", "iuid": "52346200eaa64ea0a9b13640d47de9e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/52346200eaa64ea0a9b13640d47de9e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/52346200eaa64ea0a9b13640d47de9e2"}}, "title": "Interassociation consensus recommendations for pitch-side emergency care and personal protective equipment for elite sport during the COVID-19 pandemic.", "authors": [{"family": "Hodgson", "given": "Lisa", "initials": "L"}, {"family": "Phillips", "given": "Gemma", "initials": "G"}, {"family": "Gordon", "given": "Jonathan", "initials": "J"}, {"family": "Hanson", "given": "Jonathan", "initials": "J"}, {"family": "Maclean", "given": "John", "initials": "J"}, {"family": "Mathema", "given": "Prabhat", "initials": "P"}, {"family": "Smith", "given": "Andrew", "initials": "A"}, {"family": "Woolcock", "given": "Mark", "initials": "M"}, {"family": "Cowie", "given": "Charlotte M", "initials": "CM"}, {"family": "Kemp", "given": "Simon", "initials": "S"}, {"family": "Patterson", "given": "Michael", "initials": "M"}, {"family": "Larkin", "given": "Jo", "initials": "J"}, {"family": "Hill", "given": "Jerry", "initials": "J"}, {"family": "Rossiter", "given": "Michael", "initials": "M"}, {"family": "Elliott", "given": "Niall", "initials": "N"}, {"family": "Bennett", "given": "Pippa", "initials": "P"}, {"family": "Power", "given": "Jonathan", "initials": "J"}, {"family": "Pillay", "given": "Ari", "initials": "A"}, {"family": "Singh", "given": "Harjinder", "initials": "H"}, {"family": "Sheridan", "given": "Craig", "initials": "C"}, {"family": "Hurwood", "given": "Matthew", "initials": "M"}, {"family": "Riou", "given": "Peter", "initials": "P"}, {"family": "Bennison", "given": "Anthony", "initials": "A"}, {"family": "Chakraverty", "given": "Susan", "initials": "S"}, {"family": "Tingay", "given": "Richard", "initials": "R"}, {"family": "Higgins", "given": "Richard", "initials": "R"}, {"family": "Weiler", "given": "Richard", "initials": "R"}, {"family": "Jaques", "given": "Rod", "initials": "R"}, {"family": "Spencer", "given": "Simon", "initials": "S"}, {"family": "Carmont", "given": "Michael R", "initials": "MR"}, {"family": "Patricios", "given": "Jon", "initials": "J"}], "type": "journal article", "published": "2020-12-24", "journal": {"title": "Br J Sports Med", "issn": "1473-0480", "volume": null, "issue": null, "pages": "bjsports-2020-103226", "issn-l": null}, "abstract": "The COVID-19 pandemic has necessitated many novel responses in healthcare including sport and exercise medicine. The cessation of elite sport almost globally has had significant economic implications and resulted in pressure to resume sport in very controlled conditions. This includes protecting pitch-side medical staff and players from infection. The ongoing prevalence of SARS-CoV-2 and the desire to resume professional sport required urgent best practice guidelines to be developed so that sport could be resumed as safely as possible. This set of best practice recommendations assembles early evidence for managing SARS-CoV-2 and integrates expert opinion to provide a uniform and pragmatic approach to enhance on-field and pitch-side safety for the clinician and player. The nature of SARS-CoV-2 transmission creates new hazards during resuscitation and emergency care and procedures. Recommendations for the use and type of personal protective equipment during on-field or pitch-side emergency medical care is provided based on the clinical scenario and projected risk of viral transmission.", "doi": "10.1136/bjsports-2020-103226", "pmid": "33361278", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bjsports-2020-103226"}, {"db": "pmc", "key": "PMC7768617"}], "notes": [], "created": "2021-01-07T13:43:34.897Z", "modified": "2021-01-10T17:27:46.284Z"}, {"entity": "publication", "iuid": "3b90f2b1a6614f01a77d54eccf59c5fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b90f2b1a6614f01a77d54eccf59c5fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b90f2b1a6614f01a77d54eccf59c5fd"}}, "title": "Doctor at Your Fingertips: An Exploration of Digital Visits from Stakeholders' Perspectives.", "authors": [{"family": "Demi", "given": "Selina", "initials": "S"}, {"family": "Hilmy", "given": "Samir", "initials": "S"}, {"family": "Keller", "given": "Christina", "initials": "C"}], "type": "journal article", "published": "2020-12-24", "journal": {"title": "Life (Basel)", "issn": "2075-1729", "volume": "11", "issue": "1", "issn-l": null}, "abstract": "Technological advances and the evolution of mobile technologies enable patients to meet their doctors through their smartphones. While offering the opportunity of digital visits to patients, there are also challenges for this development. The purpose of this study is to enhance the understanding of digital visits, as perceived by experts working in telemedicine companies. To serve this purpose, the authors conducted semi-structured interviews with managers and employees in eight telemedicine companies. The analysis of the empirical data confirmed the importance of digital visits and their efficiency. The potential of digital visits is expected to increase significantly, should they make use of remote devices to transfer real-time data from patients to physicians. In such a case, digital visits are expected to cover approximately 70-75% of medical cases. However, the use of remote devices must be taken with caution and specific conditions need to be taken into account. We encourage researchers to perform research on promising technologies such as artificial intelligence and remote diagnostic devices, which could make more diagnoses and conditions possible to be treated by digital visits. This is even more important in light of the ongoing Covid-19 pandemic.", "doi": "10.3390/life11010006", "pmid": "33374106", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "life11010006"}], "notes": [], "created": "2021-01-07T12:16:55.160Z", "modified": "2021-02-26T08:46:59.920Z"}, {"entity": "publication", "iuid": "6f875a8ff1de4906add4110bf19cb5b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f875a8ff1de4906add4110bf19cb5b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f875a8ff1de4906add4110bf19cb5b3"}}, "title": "Improving Hospital Oxygen Systems for COVID-19 in Low-Resource Settings: Lessons From the Field", "authors": [{"family": "Graham", "given": "Hamish R", "initials": "HR"}, {"family": "Bagayana", "given": "Sheillah M", "initials": "SM"}, {"family": "Bakare", "given": "Ayobami A", "initials": "AA"}, {"family": "Olayo", "given": "Bernard O", "initials": "BO"}, {"family": "Peterson", "given": "Stefan S", "initials": "SS"}, {"family": "Duke", "given": "Trevor", "initials": "T"}, {"family": "Falade", "given": "Adegoke G", "initials": "AG"}], "type": "journal-article", "published": "2020-12-23", "journal": {"title": "Glob Health Sci Pract", "issn": "2169-575X", "volume": "8", "issue": "4", "pages": "858-862", "issn-l": null}, "abstract": "Oxygen therapy is an essential medicine and core component of effective hospital systems. However, many hospitals in low- and middle-income countries lack reliable oxygen access-a deficiency highlighted and exacerbated by the coronavirus disease (COVID-19) pandemic. Oxygen access can be challenged by equipment that is low quality and poorly maintained, lack of clinical and technical training and protocols, and deficiencies in local infrastructure and policy environment. We share learnings from 2 decades of oxygen systems work with hospitals in Africa and the Asia-Pacific regions, highlighting practical actions that hospitals can take to immediately expand oxygen access. These include strategies to: (1) improve pulse oximetry and oxygen use, (2) support biomedical engineers to optimize existing oxygen supplies, and (3) expand on existing oxygen systems with robust equipment and smart design. We make all our resources freely available for use and local adaptation.", "doi": "10.9745/ghsp-d-20-00224", "pmid": "33361248", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-10T17:28:22.586Z", "modified": "2021-02-26T08:45:48.299Z"}, {"entity": "publication", "iuid": "109ae59a123f4d558105cb7048e44995", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/109ae59a123f4d558105cb7048e44995.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/109ae59a123f4d558105cb7048e44995"}}, "title": "Spices to Control COVID-19 Symptoms: Yes, but Not Only\u2026.", "authors": [{"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Czarlewski", "given": "Wienczyslawa", "initials": "W"}, {"family": "Zuberbier", "given": "Torsten", "initials": "T"}, {"family": "Mullol", "given": "Joaquim", "initials": "J"}, {"family": "Blain", "given": "Hubert", "initials": "H"}, {"family": "Cristol", "given": "Jean-Paul", "initials": "JP"}, {"family": "De La Torre", "given": "Rafael", "initials": "R"}, {"family": "Le Moing", "given": "Vincent", "initials": "V"}, {"family": "Pizarro Lozano", "given": "Nieves", "initials": "N"}, {"family": "Bedbrook", "given": "Anna", "initials": "A"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Akdis", "given": "Cezmi A", "initials": "CA"}, {"family": "Canonica", "given": "G Walter", "initials": "GW"}, {"family": "Cruz", "given": "Alvaro A", "initials": "AA"}, {"family": "Fiocchi", "given": "Alessandro", "initials": "A"}, {"family": "Fonseca", "given": "Joao A", "initials": "JA"}, {"family": "Fonseca", "given": "Susana", "initials": "S"}, {"family": "Gemicio\u011flu", "given": "Bilun", "initials": "B"}, {"family": "Haahtela", "given": "Tari", "initials": "T"}, {"family": "Iaccarino", "given": "Guido", "initials": "G"}, {"family": "Ivancevich", "given": "Juan Carlos", "initials": "JC"}, {"family": "Jutel", "given": "Marek", "initials": "M"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Kuna", "given": "Piotr", "initials": "P"}, {"family": "Larenas-Linnemann", "given": "D\u00e9sir\u00e9e E", "initials": "DE"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Okamoto", "given": "Yoshitaka", "initials": "Y"}, {"family": "Papadopoulos", "given": "Nikolaos G", "initials": "NG"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Reynes", "given": "Jacques", "initials": "J"}, {"family": "Rolland", "given": "Yves", "initials": "Y"}, {"family": "Rouadi", "given": "Philip W", "initials": "PW"}, {"family": "Samolinski", "given": "Boleslaw", "initials": "B"}, {"family": "Sheikh", "given": "Aziz", "initials": "A"}, {"family": "Toppila-Salmi", "given": "Sanna", "initials": "S"}, {"family": "Valiulis", "given": "Arunas", "initials": "A"}, {"family": "Choi", "given": "Hak-Jong", "initials": "HJ"}, {"family": "Kim", "given": "Hyun Ju", "initials": "HJ"}, {"family": "Anto", "given": "Josep M", "initials": "JM"}], "type": "journal article", "published": "2020-12-22", "journal": {"title": "Int Arch Allergy Immunol", "issn": "1018-2438", "volume": "182", "issue": "6", "pages": "489-495", "issn-l": null}, "abstract": "There are large country variations in COVID-19 death rates that may be partly explained by diet. Many countries with low COVID-19 death rates have a common feature of eating large quantities of fermented vegetables such as cabbage and, in some continents, various spices. Fermented vegetables and spices are agonists of the antioxidant transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and spices are transient receptor potential ankyrin 1 and vanillin 1 (TRPA1/V1) agonists. These mechanisms may explain many COVID-19 symptoms and severity. It appears that there is a synergy between Nrf2 and TRPA1/V1 foods that may explain the role of diet in COVID-19. One of the mechanisms of COVID-19 appears to be an oxygen species (ROS)-mediated process in synergy with TRP channels, modulated by Nrf2 pathways. Spicy foods are likely to desensitize TRP channels and act in synergy with exogenous antioxidants that activate the Nrf2 pathway.", "doi": "10.1159/000513538", "pmid": "33352565", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "000513538"}, {"db": "pmc", "key": "PMC7900475"}], "notes": [], "created": "2021-01-08T08:23:27.711Z", "modified": "2021-07-14T07:52:46.595Z"}, {"entity": "publication", "iuid": "61cc72674c1b4238a17acd0e8258e2fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61cc72674c1b4238a17acd0e8258e2fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61cc72674c1b4238a17acd0e8258e2fd"}}, "title": "Sex and age differences in COVID-19 mortality in Europe", "authors": [{"family": "Ahrenfeldt", "given": "Linda Juel", "initials": "LJ"}, {"family": "Otavova", "given": "Martina", "initials": "M"}, {"family": "Christensen", "given": "Kaare", "initials": "K"}, {"family": "Lindahl-Jacobsen", "given": "Rune", "initials": "R"}], "type": "journal-article", "published": "2020-12-22", "journal": {"title": "Wien Klin Wochenschr", "issn": "0043-5325", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1007/s00508-020-01793-9", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-10T17:35:36.357Z", "modified": "2021-02-26T08:46:59.983Z"}, {"entity": "publication", "iuid": "e1e465b949a64f3ab9edb94f803cc998", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e1e465b949a64f3ab9edb94f803cc998.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e1e465b949a64f3ab9edb94f803cc998"}}, "title": "Potentially Prolonged Psychological Distress from Postponed Olympic and Paralympic Games during COVID-19-Career Uncertainty in Elite Athletes.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "Moesch", "given": "Karin", "initials": "K"}, {"family": "J\u00f6nsson", "given": "Caroline", "initials": "C"}, {"family": "Kentt\u00e4", "given": "G\u00f6ran", "initials": "G"}], "type": "journal article", "published": "2020-12-22", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "1", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on the world of sports due to periods of home quarantine, bans against public gatherings, travel restrictions, and a large number of postponed or canceled major sporting events. The literature hitherto is sparse, but early indications display signs of psychological impact on elite athletes due to the pandemic. However, beyond acute effects from lockdown and short-term interrupted athletic seasons, the postponed and still uncertain Olympic and Paralympic Games may represent a major career insecurity to many athletes world-wide, and may lead to severe changes to everyday lives and potentially prolonged psychological distress. Given the long-term perspective of these changes, researchers and stakeholders should address mental health and long-term job insecurity in athletes, including a specific focus on those with small financial margins, such as many female athletes, parasports athletes, athletes in smaller sports, and athletes from developing countries. Implications and the need for research are discussed.", "doi": "10.3390/ijerph18010002", "pmid": "33374935", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph18010002"}], "notes": [], "created": "2021-01-07T12:14:31.841Z", "modified": "2021-02-26T08:47:00.247Z"}, {"entity": "publication", "iuid": "a99f54c3366840b9b773368a79f5ae97", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a99f54c3366840b9b773368a79f5ae97.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a99f54c3366840b9b773368a79f5ae97"}}, "title": "Modelling the effect of the COVID-19 pandemic on violent discipline against children.", "authors": [{"family": "Fabbri", "given": "Camilla", "initials": "C"}, {"family": "Bhatia", "given": "Amiya", "initials": "A"}, {"family": "Petzold", "given": "Max", "initials": "M"}, {"family": "Jugder", "given": "Munkhbadar", "initials": "M"}, {"family": "Guedes", "given": "Alessandra", "initials": "A"}, {"family": "Cappa", "given": "Claudia", "initials": "C"}, {"family": "Devries", "given": "Karen", "initials": "K"}], "type": "journal article", "published": "2020-12-22", "journal": {"title": "Child Abuse Negl", "issn": "1873-7757", "volume": null, "issue": null, "pages": "104897", "issn-l": null}, "abstract": "The COVID-19 pandemic could increase violence against children at home. However, collecting empirical data on violence is challenging due to ethical, safety, and data quality concerns.\n\nThis study estimated the anticipated effect of COVID-19 on violent discipline at home using multivariable predictive regression models.\n\nChildren aged 1-14 years and household members from the Multiple Indicator Cluster Surveys (MICS) conducted in Nigeria, Mongolia, and Suriname before the COVID-19 pandemic were included.\n\nA conceptual model of how the COVID-19 pandemic could affect risk factors for violent discipline was developed. Country specific multivariable linear models were used to estimate the association between selected variables from MICS and a violent discipline score which captured the average combination of violent disciplinary methods used in the home. A review of the literature informed the development of quantitative assumptions about how COVID-19 would impact the selected variables under a \"high restrictions\" pandemic scenario, approximating conditions expected during a period of intense response measures, and a \"lower restrictions\" scenario with easing of COVID-19 restrictions but with sustained economic impacts. These assumptions were used to estimate changes in violent discipline scores.\n\nUnder a \"high restrictions\" scenario there would be a 35%-46% increase in violent discipline scores in Nigeria, Mongolia and Suriname, and under a \"lower restrictions\" scenario there would be between a 4%-6% increase in violent discipline scores in these countries.\n\nPolicy makers need to plan for increases in violent discipline during successive waves of lockdowns.", "doi": "10.1016/j.chiabu.2020.104897", "pmid": "33451678", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0145-2134(20)30552-4"}], "notes": [], "created": "2021-01-18T14:37:30.758Z", "modified": "2021-02-26T08:47:00.147Z"}, {"entity": "publication", "iuid": "8da68cb7dd1e494f9d694277f8730a4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8da68cb7dd1e494f9d694277f8730a4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8da68cb7dd1e494f9d694277f8730a4c"}}, "title": "Implications and Limitations of Social Distancing Strategies (SDS) to Mitigate the Impact of the COVID-19 Pandemic.", "authors": [{"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}, {"family": "Burkle", "given": "Frederick M", "initials": "FM"}, {"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}], "type": "journal article", "published": "2020-12-22", "journal": {"title": "Disaster Med Public Health Prep", "issn": "1938-744X", "volume": null, "issue": null, "pages": "1-2", "issn-l": "1935-7893"}, "abstract": null, "doi": "10.1017/dmp.2020.500", "pmid": "33769241", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1935789320005005"}], "notes": [], "created": "2021-03-29T09:26:41.822Z", "modified": "2021-03-29T09:26:41.833Z"}, {"entity": "publication", "iuid": "7029db400dfd4e1592553190873fbe5b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7029db400dfd4e1592553190873fbe5b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7029db400dfd4e1592553190873fbe5b"}}, "title": "Development and external validation of a logistic regression derived formula based on repeated routine hematological measurements predicting survival of hospitalized Covid-19 patients", "authors": [{"family": "Heber", "given": "Stefan", "initials": "S"}, {"family": "Pereyra", "given": "David", "initials": "D"}, {"family": "Schrottmaier", "given": "Waltraud C", "initials": "WC"}, {"family": "Kammerer", "given": "Kerstin", "initials": "K"}, {"family": "Santol", "given": "Jonas", "initials": "J"}, {"family": "Pawelka", "given": "Erich", "initials": "E"}, {"family": "Hana", "given": "Markus", "initials": "M"}, {"family": "Scholz", "given": "Alexander", "initials": "A"}, {"family": "Liu", "given": "Markus", "initials": "M"}, {"family": "Hell", "given": "Agnes", "initials": "A"}, {"family": "Heiplik", "given": "Klara", "initials": "K"}, {"family": "Lickefett", "given": "Benno", "initials": "B"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Traugott", "given": "Marianna T", "initials": "MT"}, {"family": "Neub\u00f6ck", "given": "Matthias", "initials": "M"}, {"family": "Sch\u00f6rgenhofer", "given": "Christian", "initials": "C"}, {"family": "Seitz", "given": "Tamara", "initials": "T"}, {"family": "Firbas", "given": "Christa", "initials": "C"}, {"family": "Karolyi", "given": "Mario", "initials": "M"}, {"family": "Weiss", "given": "G\u00fcnter", "initials": "G"}, {"family": "Jilma", "given": "Bernd", "initials": "B"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Bellmann-Weiler", "given": "Rosa", "initials": "R"}, {"family": "Salzer", "given": "Helmut J F", "initials": "HJF"}, {"family": "Fischer", "given": "Michael J M", "initials": "MJM"}, {"family": "Zoufaly", "given": "Alexander", "initials": "A"}, {"family": "Assinger", "given": "Alice", "initials": "A"}], "type": "posted-content", "published": "2020-12-22", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.20.20248563", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-04T08:54:38.303Z", "modified": "2021-02-26T08:46:13.223Z"}, {"entity": "publication", "iuid": "d22a5c0867e647ceb971ab628b8454eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d22a5c0867e647ceb971ab628b8454eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d22a5c0867e647ceb971ab628b8454eb"}}, "title": "COVID-19 and the Swedish enigma.", "authors": [{"family": "Claeson", "given": "Mariam", "initials": "M"}, {"family": "Hanson", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2020-12-22", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": null, "issue": null, "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)32750-1", "pmid": "33357494", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)32750-1"}, {"db": "pmc", "key": "PMC7755568"}], "notes": [], "created": "2021-01-08T08:19:51.738Z", "modified": "2021-01-10T17:30:11.876Z"}, {"entity": "publication", "iuid": "e5fe6d45987442a8ac2cf0c4068949e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e5fe6d45987442a8ac2cf0c4068949e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e5fe6d45987442a8ac2cf0c4068949e7"}}, "title": "Impact of simulation-based teamwork training on COVID-19 distress in healthcare professionals.", "authors": [{"family": "Beneria", "given": "Anna", "initials": "A"}, {"family": "Arnedo", "given": "Mireia", "initials": "M"}, {"family": "Contreras", "given": "Sofia", "initials": "S"}, {"family": "P\u00e9rez-Carrasco", "given": "Marco", "initials": "M"}, {"family": "Garcia-Ruiz", "given": "Itziar", "initials": "I"}, {"family": "Rodr\u00edguez-Carballeira", "given": "M\u00f3nica", "initials": "M"}, {"family": "Radu\u00e0", "given": "Joaquim", "initials": "J"}, {"family": "Rius", "given": "Jordi Ba\u00f1eras", "initials": "JB"}], "type": "journal article", "published": "2020-12-21", "journal": {"title": "BMC Med Educ", "issn": "1472-6920", "volume": "20", "issue": "1", "pages": "515", "issn-l": null}, "abstract": "Non-technical skills such as leadership, communication, or situation awareness should lead to effective teamwork in a crisis. This study aimed to analyse the role of these skills in the emotional response of health professionals to the COVID-19 pandemic.\n\nBefore the COVID-19 outbreak, 48 doctors and 48 nurses participated in a simulation-based teamwork training program based on teaching non-technical skills through simulation. In May 2020, this group of professionals from a COVID-19 referral hospital was invited to participate in a survey exploring stress, anxiety, and depression, using the PSS-14 (Perceived Stress Scale) and the HADS (Hospital Anxiety and Depression Scale) measures. A control group that did not receive the training was included. We conducted a logistic regression to assess whether having attended a simulation-based teamwork training program modified the probability of presenting psychological distress (PSS-14 > 18 or HADS> 12).\n\nA total of 141 healthcare professionals were included, 77 in the intervention group and 64 in the control group. Based on the PSS-14, 70.1% of the intervention group and 75% of the control group (p = 0.342) had symptoms of stress. Having contact with COVID-19 patients [OR 4.16(1.64-10.52)]; having minors in charge [OR 2.75 (1.15-6.53)]; working as a doctor [0.39(0.16-0.95)], and being a woman [OR 2.94(1.09-7.91)] were related with PSS14 symptoms. Based on the HADS, 54.6% of the intervention group and 42.2% of the control group (p = 0.346) had symptoms of anxiety or depression. Having contact with COVID-19 patients [OR 2.17(1.05-4.48)] and having minors in charge [OR 2.14(1.06-4.32)] were related to HADS symptoms. Healthcare professionals who attended COVID-19 patients showed higher levels of anxiety and depression [OR 2.56(1.03-6.36) (p = 0.043)].\n\nHealthcare professionals trained in non-technical skills through simulation tended towards higher levels of anxiety and depression and fewer levels of stress, during the COVID-19 pandemic.", "doi": "10.1186/s12909-020-02427-4", "pmid": "33349248", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12909-020-02427-4"}, {"db": "pmc", "key": "PMC7751744"}, {"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-08T08:24:47.491Z", "modified": "2021-02-26T08:47:00.263Z"}, {"entity": "publication", "iuid": "d9ea5ba12df64dcf9f67088c9302d0ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d9ea5ba12df64dcf9f67088c9302d0ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d9ea5ba12df64dcf9f67088c9302d0ee"}}, "title": "Covid-19 intensive care admissions and mortality among swedish patients with cancer.", "authors": [{"family": "Larfors", "given": "Gunnar", "initials": "G"}, {"family": "Pahnke", "given": "Simon", "initials": "S"}, {"family": "State", "given": "Maria", "initials": "M"}, {"family": "Fredriksson", "given": "Katarina", "initials": "K"}, {"family": "Pettersson", "given": "David", "initials": "D"}], "type": "letter", "published": "2020-12-21", "journal": {"title": "Acta Oncol", "issn": "1651-226X", "volume": null, "issue": null, "pages": "1-3", "issn-l": null}, "abstract": null, "doi": "10.1080/0284186X.2020.1854481", "pmid": "33345664", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-07T13:30:27.979Z", "modified": "2021-02-26T08:45:48.781Z"}, {"entity": "publication", "iuid": "be488f3e4f824c5a83f9ad103c1b7a5d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be488f3e4f824c5a83f9ad103c1b7a5d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be488f3e4f824c5a83f9ad103c1b7a5d"}}, "title": "Mental health among pregnant women during the pandemic in Sweden\u2013 a mixed methods approach using data from the Mom2B mobile application for research", "authors": [{"family": "Fransson", "given": "Emma", "initials": "E", "orcid": "0000-0001-9010-8522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c3926adfe6e74e91b084e1e5531af80e.json"}}, {"family": "Karalexi", "given": "Maria", "initials": "M"}, {"family": "Kimmel", "given": "Mary", "initials": "M", "orcid": "0000-0002-6270-5394", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/55a598795f8f4202a6006ba71081d0d0.json"}}, {"family": "Br\u00e4nn", "given": "Emma", "initials": "E", "orcid": "0000-0001-9664-7973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3add26b456fd4ce0ad3e649aa7aa4dff.json"}}, {"family": "Kollia", "given": "Natasa", "initials": "N", "orcid": "0000-0001-7868-3524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6bbd460a1869481b9dcbf80263ef27e5.json"}}, {"family": "van Zoest", "given": "Vera", "initials": "V", "orcid": "0000-0002-3017-0874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72aee535dc8c45478a4cf678e01d2421.json"}}, {"family": "Nordling", "given": "Eira", "initials": "E"}, {"family": "Papadopoulos", "given": "Fotios C", "initials": "FC", "orcid": "0000-0002-8692-3652", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a12a16c269b479f81b6f8306185cada.json"}}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A", "orcid": "0000-0002-4935-7532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76c46ccb0ade4acaa7b53f3fd4240683.json"}}], "type": "posted-content", "published": "2020-12-20", "journal": {"title": "", "issn": null, "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1101/2020.12.18.20248466", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-10T04:11:26.328Z", "modified": "2021-06-14T06:39:03.115Z"}, {"entity": "publication", "iuid": "8cf9f12e77c94c808fc63cfc8aadd3b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8cf9f12e77c94c808fc63cfc8aadd3b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8cf9f12e77c94c808fc63cfc8aadd3b4"}}, "title": "Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale", "authors": [{"family": "Paramasivam", "given": "Prasath", "initials": "P"}, {"family": "Franke", "given": "Christian", "initials": "C"}, {"family": "St\u00f6ter", "given": "Martin", "initials": "M"}, {"family": "H\u00f6ijer", "given": "Andreas", "initials": "A"}, {"family": "Bartesaghi", "given": "Stefano", "initials": "S"}, {"family": "Sabirsh", "given": "Alan", "initials": "A"}, {"family": "Lindfors", "given": "Lennart", "initials": "L"}, {"family": "Yanez Arteta", "given": "Marianna", "initials": "M"}, {"family": "Dahl\u00e9n", "given": "Anders", "initials": "A"}, {"family": "Bak", "given": "Annette", "initials": "A"}, {"family": "Andersson", "given": "Shalini", "initials": "S"}, {"family": "Kalaidzidis", "given": "Yannis", "initials": "Y"}, {"family": "Bickle", "given": "Marc", "initials": "M"}, {"family": "Zerial", "given": "Marino", "initials": "M"}], "type": "posted-content", "published": "2020-12-20", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.18.423541", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-15T15:56:01.936Z", "modified": "2021-02-26T08:45:48.453Z"}, {"entity": "publication", "iuid": "7b1c5fe3808e43868029cd853560c02a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b1c5fe3808e43868029cd853560c02a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b1c5fe3808e43868029cd853560c02a"}}, "title": "Considerations for scuba and breath-hold divers during the COVID-19 pandemic: A call for awareness.", "authors": [{"family": "Elia", "given": "Antonis", "initials": "A"}, {"family": "Gennser", "given": "Mikael", "initials": "M"}], "type": "journal article", "published": "2020-12-20", "journal": {"title": "Diving Hyperb Med", "issn": "1833-3516", "volume": "50", "issue": "4", "pages": "413-416", "issn-l": null}, "abstract": "In late 2019, a highly pathogenic novel coronavirus (CoV), severe acute respiratory syndrome (SARS)-CoV-2 emerged from Wuhan, China and led to a global pandemic. SARS-CoV-2 has a predilection for the pulmonary system and can result in serious pneumonia necessitating hospitalisation. Computed tomography (CT) chest scans of patients with severe symptoms, show signs of multifocal bilateral ground or ground-glass opacities (GGO) associated with consolidation areas with patchy distribution. However, it is less well known that both asymptomatic and mild symptomatic patients may exhibit similar lung changes. Presumably, the various pathological changes in the lungs may increase the risk of adverse events during diving (e.g., lung barotrauma, pulmonary oedema, etc.), thus these lung manifestations need to be considered prior to allowing resumption of diving. Presently, it is not known how the structural changes in the lungs develop and to what extent they resolve, in particular in asymptomatic carriers and patients with mild disease. However, current evidence indicates that a month of recovery may be too short an interval to guarantee complete pulmonary restitution even after COVID-19 infections not demanding hospital care.", "doi": "10.28920/dhm50.4.413-416", "pmid": "33325024", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-21T10:00:27.634Z", "modified": "2021-01-10T18:14:36.428Z"}, {"entity": "publication", "iuid": "5896670bf8704d568137c3fb607add22", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5896670bf8704d568137c3fb607add22.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5896670bf8704d568137c3fb607add22"}}, "title": "Effects on Gambling Activity From Coronavirus Disease 2019-An Analysis of Revenue-Based Taxation of Online- and Land-Based Gambling Operators During the Pandemic.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-12-17", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "11", "issue": null, "pages": "611939", "issn-l": "1664-0640"}, "abstract": "Background: Concerns have been raised about increased gambling problems during the coronavirus disease (COVID-19) crisis, particularly in settings with high online gambling and risks of migration from land-based to riskier online-based gambling types. However, few non-self-reported data sources are hitherto available. The present study aimed to assess changes in the online- and land-based gambling markets in Sweden during the first months affected by the societal impact of COVID-19. Methods: Data were derived from national authority data describing monthly taxations of all licensed Swedish gambling operators, whose monthly tax payments are directly based on gambling revenue. Subdivisions of the gambling market were followed monthly from before COVID-19 onset in Sweden (mainly February 2020) through June 2020, when the sports market was restarted after COVID-19 lockdown. Results: Overall revenue-based taxations in the licensed gambling decreased markedly from February to March, but stabilized onto an overall modest decrease through June. Commercial online casino/betting, despite some decrease in March, was maintained on a relatively stable level through June. However, within this category, horse betting increased steeply during the pandemic but returned to prepandemic levels later during the period. The state-owned operator in betting/online casino decreased markedly throughout the pandemic. The remaining commercial operators, mainly in online casino and online betting, demonstrated no change during the pandemic and ended on a June level 14% above the February level. Throughout the pandemic, the smaller restaurant casinos decreased markedly, while major state-owned casinos also closed entirely. State-owned lotteries and electronic gambling machines decreased markedly but were rapidly normalized to prepandemic levels. Conclusions: Commercial online gambling operators' revenues remained stable throughout the pandemic, despite the dramatic lockdown in sports. Thus, chance-based online games may have remained a strong actor in the gambling market despite the COVID-19 crisis, in line with previous self-report data. A sudden increase in horse betting during the sports lockdown and its decrease when sports reopened confirm the picture of possible COVID-19-related migration between gambling types, indicating a volatility with potential impact on gambling-related public health.", "doi": "10.3389/fpsyt.2020.611939", "pmid": "33391059", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7773659"}], "notes": [], "created": "2021-01-05T15:18:01.702Z", "modified": "2021-02-26T08:46:59.964Z"}, {"entity": "publication", "iuid": "02b49bae4e8c42dcaecb844185a7ae94", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02b49bae4e8c42dcaecb844185a7ae94.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02b49bae4e8c42dcaecb844185a7ae94"}}, "title": "Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy.", "authors": [{"family": "Wacker", "given": "Anna", "initials": "A"}, {"family": "Weigand", "given": "Julia E", "initials": "JE", "orcid": "0000-0003-4247-1348", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5229ec08ce9242c19049804ff8a77085.json"}}, {"family": "Akabayov", "given": "Sabine R", "initials": "SR"}, {"family": "Altincekic", "given": "Nadide", "initials": "N"}, {"family": "Bains", "given": "Jasleen Kaur", "initials": "JK"}, {"family": "Banijamali", "given": "Elnaz", "initials": "E"}, {"family": "Binas", "given": "Oliver", "initials": "O"}, {"family": "Castillo-Martinez", "given": "Jesus", "initials": "J"}, {"family": "Cetiner", "given": "Erhan", "initials": "E"}, {"family": "Ceylan", "given": "Bet\u00fcl", "initials": "B"}, {"family": "Chiu", "given": "Liang-Yuan", "initials": "LY"}, {"family": "Davila-Calderon", "given": "Jesse", "initials": "J"}, {"family": "Dhamotharan", "given": "Karthikeyan", "initials": "K"}, {"family": "Duchardt-Ferner", "given": "Elke", "initials": "E"}, {"family": "Ferner", "given": "Jan", "initials": "J"}, {"family": "Frydman", "given": "Lucio", "initials": "L"}, {"family": "F\u00fcrtig", "given": "Boris", "initials": "B", "orcid": "0000-0001-6443-7656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5e0849167334290a5bd6691644783bf.json"}}, {"family": "Gallego", "given": "Jos\u00e9", "initials": "J", "orcid": "0000-0002-0627-6927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b188371610a46858542181b11863966.json"}}, {"family": "Gr\u00fcn", "given": "J Tassilo", "initials": "JT"}, {"family": "Hacker", "given": "Carolin", "initials": "C"}, {"family": "Haddad", "given": "Christina", "initials": "C"}, {"family": "H\u00e4hnke", "given": "Martin", "initials": "M"}, {"family": "Hengesbach", "given": "Martin", "initials": "M", "orcid": "0000-0001-9414-1602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa75083441294b4f8fe68b1a42fee601.json"}}, {"family": "Hiller", "given": "Fabian", "initials": "F"}, {"family": "Hohmann", "given": "Katharina F", "initials": "KF"}, {"family": "Hymon", "given": "Daniel", "initials": "D"}, {"family": "de Jesus", "given": "Vanessa", "initials": "V"}, {"family": "Jonker", "given": "Henry", "initials": "H"}, {"family": "Keller", "given": "Heiko", "initials": "H"}, {"family": "Knezic", "given": "Bozana", "initials": "B"}, {"family": "Landgraf", "given": "Tom", "initials": "T"}, {"family": "L\u00f6hr", "given": "Frank", "initials": "F"}, {"family": "Luo", "given": "Le", "initials": "L"}, {"family": "Mertinkus", "given": "Klara R", "initials": "KR"}, {"family": "Muhs", "given": "Christina", "initials": "C"}, {"family": "Novakovic", "given": "Mihajlo", "initials": "M"}, {"family": "Oxenfarth", "given": "Andreas", "initials": "A"}, {"family": "Palomino-Sch\u00e4tzlein", "given": "Martina", "initials": "M"}, {"family": "Petzold", "given": "Katja", "initials": "K"}, {"family": "Peter", "given": "Stephen A", "initials": "SA"}, {"family": "Pyper", "given": "Dennis J", "initials": "DJ"}, {"family": "Qureshi", "given": "Nusrat S", "initials": "NS"}, {"family": "Riad", "given": "Magdalena", "initials": "M"}, {"family": "Richter", "given": "Christian", "initials": "C"}, {"family": "Saxena", "given": "Krishna", "initials": "K"}, {"family": "Schamber", "given": "Tatjana", "initials": "T"}, {"family": "Scherf", "given": "Tali", "initials": "T"}, {"family": "Schlagnitweit", "given": "Judith", "initials": "J"}, {"family": "Schlundt", "given": "Andreas", "initials": "A", "orcid": "0000-0003-2254-7560", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/662b48aa496e4109aab02871f6b1d43d.json"}}, {"family": "Schnieders", "given": "Robbin", "initials": "R"}, {"family": "Schwalbe", "given": "Harald", "initials": "H", "orcid": "0000-0001-5693-7909", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32641f04b8504ac493d46947e87e4f59.json"}}, {"family": "Simba-Lahuasi", "given": "Alvaro", "initials": "A"}, {"family": "Sreeramulu", "given": "Sridhar", "initials": "S"}, {"family": "Stirnal", "given": "Elke", "initials": "E"}, {"family": "Sudakov", "given": "Alexey", "initials": "A"}, {"family": "Tants", "given": "Jan-Niklas", "initials": "JN"}, {"family": "Tolbert", "given": "Blanton S", "initials": "BS"}, {"family": "V\u00f6gele", "given": "Jennifer", "initials": "J"}, {"family": "Wei\u00df", "given": "Lena", "initials": "L"}, {"family": "Wirmer-Bartoschek", "given": "Julia", "initials": "J"}, {"family": "Wirtz Martin", "given": "Maria A", "initials": "MA"}, {"family": "W\u00f6hnert", "given": "Jens", "initials": "J", "orcid": "0000-0001-7193-401X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/611eebfc08f54e20b4dc9b881da010b8.json"}}, {"family": "Zetzsche", "given": "Heidi", "initials": "H"}], "type": "journal article", "published": "2020-12-16", "journal": {"title": "Nucleic Acids Res", "issn": "1362-4962", "volume": "48", "issue": "22", "pages": "12415-12435", "issn-l": "0305-1048"}, "abstract": "The current pandemic situation caused by the Betacoronavirus SARS-CoV-2 (SCoV2) highlights the need for coordinated research to combat COVID-19. A particularly important aspect is the development of medication. In addition to viral proteins, structured RNA elements represent a potent alternative as drug targets. The search for drugs that target RNA requires their high-resolution structural characterization. Using nuclear magnetic resonance (NMR) spectroscopy, a worldwide consortium of NMR researchers aims to characterize potential RNA drug targets of SCoV2. Here, we report the characterization of 15 conserved RNA elements located at the 5' end, the ribosomal frameshift segment and the 3'-untranslated region (3'-UTR) of the SCoV2 genome, their large-scale production and NMR-based secondary structure determination. The NMR data are corroborated with secondary structure probing by DMS footprinting experiments. The close agreement of NMR secondary structure determination of isolated RNA elements with DMS footprinting and NMR performed on larger RNA regions shows that the secondary structure elements fold independently. The NMR data reported here provide the basis for NMR investigations of RNA function, RNA interactions with viral and host proteins and screening campaigns to identify potential RNA binders for pharmaceutical intervention.", "doi": "10.1093/nar/gkaa1013", "pmid": "33167030", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7736788"}, {"db": "pii", "key": "5961789"}], "notes": [], "created": "2020-11-27T10:04:35.267Z", "modified": "2023-06-19T15:30:37.089Z"}, {"entity": "publication", "iuid": "343607ba24654e4c81bcf4e66035a688", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/343607ba24654e4c81bcf4e66035a688.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/343607ba24654e4c81bcf4e66035a688"}}, "title": "Large differences in community COVID-19 testing across geographic areas in a Swedish region with 385,000 inhabitants", "authors": [{"family": "Kennedy", "given": "Beatrice", "initials": "B"}, {"family": "Martinell", "given": "Mats", "initials": "M"}, {"family": "Hammar", "given": "Ulf", "initials": "U"}, {"family": "van Zoest", "given": "Vera", "initials": "V"}, {"family": "Kristiansson", "given": "Robert S", "initials": "RS"}, {"family": "Fitipaldi", "given": "Hugo", "initials": "H"}, {"family": "Tsereteli", "given": "Neli", "initials": "N"}, {"family": "Varotsis", "given": "Georgios", "initials": "G"}, {"family": "Dekkers", "given": "Koen", "initials": "K"}, {"family": "Bjork", "given": "Jonas", "initials": "J"}, {"family": "Fall", "given": "Tove", "initials": "T"}], "type": "posted-content", "published": "2020-12-16", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.15.20248247", "pmid": null, "labels": {"Type: Preprint": null, "Funder: Vinnova": null, "Category: Public Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-12-18T07:46:23.709Z", "modified": "2021-02-26T08:46:59.897Z"}, {"entity": "publication", "iuid": "2c67476bc4a941ec8ef786c921115f6a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c67476bc4a941ec8ef786c921115f6a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c67476bc4a941ec8ef786c921115f6a"}}, "title": "Effects of Dapagliflozin on Prevention of Major Clinical Events and Recovery in Patients with Respiratory Failure due to COVID-19: The Design and Rationale for the DARE-19 study.", "authors": [{"family": "Kosiborod", "given": "Mikhail", "initials": "M"}, {"family": "Berwanger", "given": "Otavio", "initials": "O"}, {"family": "Koch", "given": "Gary G", "initials": "GG"}, {"family": "Martinez", "given": "Felipe", "initials": "F"}, {"family": "Mukhtar", "given": "Omar", "initials": "O"}, {"family": "Verma", "given": "Subodh", "initials": "S"}, {"family": "Chopra", "given": "Vijay", "initials": "V"}, {"family": "Javaheri", "given": "Ali", "initials": "A"}, {"family": "Ambery", "given": "Philip", "initials": "P"}, {"family": "Gasparyan", "given": "Samvel B", "initials": "SB"}, {"family": "Buenconsejo", "given": "Joan", "initials": "J"}, {"family": "Sj\u00f6str\u00f6m", "given": "C David", "initials": "CD"}, {"family": "Langkilde", "given": "Anna Maria", "initials": "AM"}, {"family": "Oscarsson", "given": "Jan", "initials": "J"}, {"family": "Esterline", "given": "Russell", "initials": "R"}], "type": "journal article", "published": "2020-12-15", "journal": {"title": "Diabetes Obes Metab", "issn": "1463-1326", "issn-l": null, "volume": "23", "issue": "4", "pages": "886-896"}, "abstract": "Coronavirus disease 2019 (COVID-19) is caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It can lead to multiorgan failure, including respiratory and cardiovascular decompensation, and kidney injury, with significant associated morbidity and mortality, particularly in patients with underlying metabolic, cardiovascular, respiratory, or kidney disease. Dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, has shown significant cardio- and renoprotective benefits in patients with type 2 diabetes (with and without atherosclerotic cardiovascular disease), heart failure, and chronic kidney disease, and may provide similar organ protection in high-risk patients with COVID-19.\r\n\r\nDARE-19 (NCT04350593) is an investigator-initiated, collaborative, international, multicenter, randomized, double-blind, placebo-controlled study testing the dual hypotheses that dapagliflozin can reduce the incidence of cardiovascular, kidney and/or respiratory complications or all-cause mortality, or improve clinical recovery, in adult patients hospitalized with COVID-19 but not critically ill on admission. Eligible patients will have \u22651 cardiometabolic risk factor for COVID-19 complications. Patients will be randomized 1:1 to dapagliflozin 10 mg or placebo. Primary efficacy endpoints are time to development of new or worsened organ dysfunction during index hospitalization, or all-cause mortality, and the hierarchical composite endpoint of change in clinical status through Day 30 of treatment. Safety of dapagliflozin in individuals with COVID-19 will be assessed.\r\n\r\nDARE-19 will evaluate whether dapagliflozin can prevent COVID-19-related complications and all-cause mortality, or improve clinical recovery, and assess dapagliflozin's safety profile in this patient population. Currently, DARE-19 is the first large randomized controlled trial investigating use of SGLT2 inhibitors in patients with COVID-19. This article is protected by copyright. All rights reserved.", "doi": "10.1111/dom.14296", "pmid": "33319454", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-21T10:06:26.130Z", "modified": "2021-04-10T09:47:17.457Z"}, {"entity": "publication", "iuid": "a51a373837da48a78fb9bb0ed8a526c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a51a373837da48a78fb9bb0ed8a526c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a51a373837da48a78fb9bb0ed8a526c9"}}, "title": "COVID-19 Highlights the Need for Inclusive Responses to Public Health Emergencies in Africa.", "authors": [{"family": "Adebisi", "given": "Yusuff Adebayo", "initials": "YA"}, {"family": "Ekpenyong", "given": "Aniekan", "initials": "A"}, {"family": "Ntacyabukura", "given": "Blaise", "initials": "B"}, {"family": "Lowe", "given": "Mat", "initials": "M"}, {"family": "Jimoh", "given": "Nafisat Dasola", "initials": "ND"}, {"family": "Abdulkareem", "given": "Toyyib Oladimeji", "initials": "TO"}, {"family": "Lucero-Prisno", "given": "Don Eliseo", "initials": "DE"}], "type": "journal article", "published": "2020-12-15", "journal": {"title": "Am J Trop Med Hyg", "issn": "1476-1645", "volume": null, "issue": null, "issn-l": "0002-9637"}, "abstract": "COVID-19 is a global public health emergency affecting many countries around the world. Although African governments and other stakeholders are making efforts to contain the pandemic, the outbreak continues to impact human rights and exacerbates inequalities and disparities that are already in existence. The concept of inclusive health focuses on good health and well-being for everyone, and this entails health services that are equitable, affordable, and efficacious. Creating equitable access to mainstream health and healthcare services and ensuring inclusive health responses remain a means of addressing health inequities and disparities. In this article, we argue on the need for inclusive responses to public health emergencies in Africa using COVID-19 as a case example. Africa's response to public health emergencies needs to recognize that for every marginalized/vulnerable group, it is important to strategize to address their particular needs in such a way to surmount any barrier to the right to health. For Africa's public health response to be more inclusive, we therefore need to be more strategic and proactive in reaching out to specific groups and to identify and address their needs. Strengthening the healthcare systems of African countries through increased political will, increased funding to health care, collaboration and cooperation among stakeholders, and effective leadership remains essential in ensuring inclusive responses to health emergencies.", "doi": "10.4269/ajtmh.20-1485", "pmid": "33331263", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2020-12-21T08:57:29.223Z", "modified": "2021-02-26T08:47:00.142Z"}, {"entity": "publication", "iuid": "a8cae6475f344161a6e12d8f1616c9c2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8cae6475f344161a6e12d8f1616c9c2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8cae6475f344161a6e12d8f1616c9c2"}}, "title": "The coronavirus pandemic: a pitfall or a fast-track for validating cell therapy products?", "authors": [{"family": "Khoury", "given": "Maroun", "initials": "M"}, {"family": "Ikonomou", "given": "Laertis", "initials": "L"}, {"family": "Dominici", "given": "Massimo", "initials": "M"}, {"family": "Le Blanc", "given": "Katarina", "initials": "K"}, {"family": "Levine", "given": "Bruce L", "initials": "BL"}, {"family": "Weiss", "given": "Dan J", "initials": "DJ"}], "type": "journal article", "published": "2020-12-14", "journal": {"title": "Stem Cells Dev", "issn": "1557-8534", "volume": null, "issue": null, "issn-l": null}, "abstract": "The global COVID-19 pandemic has prompted urgent need for potential therapies for severe respiratory consequences resulting from coronavirus infection. New therapeutic agents that will attenuate ongoing inflammation and, at the same time, promote regeneration of injured lung epithelial cells are urgently needed. Cell-based therapies, primarily involving mesenchymal stromal cells (MSCs) and their derivatives are currently being investigated worldwide for SARS-CoV-2-induced lung diseases. A significant number of academic centers and companies globally have already initiated such trials. At a time of unprecedented need, it is it is also foreseen that distressed families, and caregivers to seek all available options including access to cell-based and other investigational products, even prior to its regulatory approval. This should not be an excuse for opportunists to sell or advertise unproven therapies of any kind. \"Compassionate use\" should be conducted in the context of a clinical investigation framed by strict ethical and regulatory permissions, with the goal of obtaining mechanistic information wherever possible.", "doi": "10.1089/scd.2020.0122", "pmid": "33307968", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-21T10:19:40.918Z", "modified": "2020-12-21T10:19:40.956Z"}, {"entity": "publication", "iuid": "79337d3b64b34c6aaa6f4da531eb17d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79337d3b64b34c6aaa6f4da531eb17d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79337d3b64b34c6aaa6f4da531eb17d9"}}, "title": "The Impact of the COVID-19 Pandemic on People with Diabetes and Diabetes Services: A pan-European Survey of Diabetes Specialist Nurses undertaken by the Foundation of European Nurses in Diabetes survey consortium.", "authors": [{"family": "Forde", "given": "Rita", "initials": "R"}, {"family": "Arente", "given": "Liga", "initials": "L"}, {"family": "Ausili", "given": "Davide", "initials": "D"}, {"family": "De Backer", "given": "Kristin", "initials": "K"}, {"family": "Due-Christensen", "given": "Mette", "initials": "M"}, {"family": "Epps", "given": "Amanda", "initials": "A"}, {"family": "Fitzpatrick", "given": "Anne", "initials": "A"}, {"family": "Grixti", "given": "Moira", "initials": "M"}, {"family": "Groen", "given": "Sijda", "initials": "S"}, {"family": "Halkoaho", "given": "Arja", "initials": "A"}, {"family": "Huber", "given": "Claudia", "initials": "C"}, {"family": "Iversen", "given": "Marjolein M", "initials": "MM"}, {"family": "Johansson", "given": "Unn-Britt", "initials": "UB"}, {"family": "Leippert", "given": "Claudia", "initials": "C"}, {"family": "Ozcan", "given": "Seyda", "initials": "S"}, {"family": "Parker", "given": "Julie", "initials": "J"}, {"family": "Paiva", "given": "Ana Christina", "initials": "AC"}, {"family": "Sanpetreanu", "given": "Adina", "initials": "A"}, {"family": "Savet", "given": "Marie-Alice", "initials": "MA"}, {"family": "Rosana", "given": "Svetic-Cisic", "initials": "SC"}, {"family": "Szewczyk", "given": "Alicja", "initials": "A"}, {"family": "Valverde", "given": "Maite", "initials": "M"}, {"family": "Vlachou", "given": "Eugenia", "initials": "E"}, {"family": "Forbes", "given": "Angus", "initials": "A"}, {"family": "FEND COVID-19 consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2020-12-14", "journal": {"title": "Diabet Med", "issn": "1464-5491", "volume": null, "issue": null, "pages": "e14498", "issn-l": null}, "abstract": "To describe diabetes nurses' perspectives on the impact of the COVID-19 pandemic on people with diabetes and diabetes services across Europe.\n\nAn online survey developed using a rapid Delphi method. The survey was translated into 17 different languages and disseminated electronically in 27 countries via national diabetes nurse networks.\n\nSurvey responses from 1829 diabetes nurses were included in the analysis. The responses indicated that 28% (n=504) and 48% (n=873) of diabetes nurses felt the COVID-19 pandemic had impacted 'a lot' on the physical and psychological risks of people with diabetes, respectively. The following clinical problems were identified as having increased 'a lot': anxiety 82% (n=1486); diabetes distress 65% (n=1189); depression 49% (n= 893); acute hyperglycaemia 39% (n=710); and foot complications 17% (n=323). Forty-seven percent (n=771) of respondents identified that the level of care provided to people with diabetes had declined either extremely or quite severely. Self-management support, diabetes education and psychological support were rated by diabetes nurse respondents as having declined extremely or quite severely during the COVID-19 pandemic by 31% (n=499), 63% (n=1,027) and 34% (n=551), respectively.\n\nThe findings show that diabetes nurses across Europe have seen significant increases in both physical and psychological problems in their patient populations during COVID-19. The data also show that clinical diabetes services have been significantly disrupted. As the COVID-19 situation continues we need to adapt care systems with some urgency to minimise the impact of the pandemic on the diabetes population.", "doi": "10.1111/dme.14498", "pmid": "33314244", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-21T10:17:40.765Z", "modified": "2021-01-08T08:18:44.786Z"}, {"entity": "publication", "iuid": "5c6f4fbc1a2247c395f119b0d31efabc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c6f4fbc1a2247c395f119b0d31efabc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c6f4fbc1a2247c395f119b0d31efabc"}}, "title": "Screening for high amounts of SARS-CoV-2 identifies pre-symptomatic subjects among healthy healthcare workers", "authors": [{"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Elfstr\u00f6m", "given": "K Miriam", "initials": "KM"}, {"family": "Blomqvist", "given": "Jonas", "initials": "J"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M"}, {"family": "Eklund", "given": "Carina", "initials": "C"}, {"family": "Boulund", "given": "Fredrik", "initials": "F"}, {"family": "Lagheden", "given": "Camilla", "initials": "C"}, {"family": "Hamsten", "given": "Marica", "initials": "M"}, {"family": "Nordqvist-Kleppe", "given": "Sara", "initials": "S"}, {"family": "Seifert", "given": "Maike", "initials": "M"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Olofsson", "given": "Jennie", "initials": "J"}, {"family": "Andersson", "given": "Eni", "initials": "E"}, {"family": "Falk", "given": "August Jernbom", "initials": "AJ"}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S"}, {"family": "Hultin", "given": "Emilie", "initials": "E"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Pimenoff", "given": "Ville N", "initials": "VN"}, {"family": "Hassan", "given": "Sadaf", "initials": "S"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Mattsson", "given": "Johan", "initials": "J"}, {"family": "M\u00fchr", "given": "Laila Sara Arroyo", "initials": "LSA"}, {"family": "Lundgren", "given": "Kalle Conneryd", "initials": "KC"}], "type": "posted-content", "published": "2020-12-14", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.13.20248122", "pmid": null, "labels": {"Type: Preprint": null, "Research Area: High-throughput and high-content serology": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}, {"db": "ClinicalTrials.gov", "key": "NCT04411576", "description": null}], "notes": [], "created": "2020-12-18T07:50:57.449Z", "modified": "2023-06-19T14:24:06.940Z"}, {"entity": "publication", "iuid": "0a55e1fb2e0d4307820500d6d439b2c4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a55e1fb2e0d4307820500d6d439b2c4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a55e1fb2e0d4307820500d6d439b2c4"}}, "title": "Rapid Assessment of Price Instability and Paucity of Medicines and Protection for COVID-19 Across Asia: Findings and Public Health Implications for the Future.", "authors": [{"family": "Godman", "given": "Brian", "initials": "B"}, {"family": "Haque", "given": "Mainul", "initials": "M"}, {"family": "Islam", "given": "Salequl", "initials": "S"}, {"family": "Iqbal", "given": "Samiul", "initials": "S"}, {"family": "Urmi", "given": "Umme Laila", "initials": "UL"}, {"family": "Kamal", "given": "Zubair Mahmood", "initials": "ZM"}, {"family": "Shuvo", "given": "Shahriar Ahmed", "initials": "SA"}, {"family": "Rahman", "given": "Aminur", "initials": "A"}, {"family": "Kamal", "given": "Mustafa", "initials": "M"}, {"family": "Haque", "given": "Monami", "initials": "M"}, {"family": "Jahan", "given": "Iffat", "initials": "I"}, {"family": "Islam", "given": "Md Zakirul", "initials": "MZ"}, {"family": "Hossain", "given": "Mohammad Monir", "initials": "MM"}, {"family": "Kumar", "given": "Santosh", "initials": "S"}, {"family": "Charan", "given": "Jaykaran", "initials": "J"}, {"family": "Bhatt", "given": "Rohan", "initials": "R"}, {"family": "Dutta", "given": "Siddhartha", "initials": "S"}, {"family": "Abhayanand", "given": "Jha Pallavi", "initials": "JP"}, {"family": "Sharma", "given": "Yesh", "initials": "Y"}, {"family": "Saleem", "given": "Zikria", "initials": "Z"}, {"family": "Phuong", "given": "Thuy Nguyen Thi", "initials": "TNT"}, {"family": "Kwon", "given": "Hye-Young", "initials": "HY"}, {"family": "Kurdi", "given": "Amanj", "initials": "A"}, {"family": "Wale", "given": "Janney", "initials": "J"}, {"family": "Sefah", "given": "Israel", "initials": "I"}], "type": "journal article", "published": "2020-12-14", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "585832", "issn-l": "2296-2565"}, "abstract": "Background: Countries have introduced a variety of measures to prevent and treat COVID-19 with medicines and personal protective equipment (PPE), with some countries adopting preventative strategies earlier than others. However, there has been considerable controversy surrounding some treatments. This includes hydroxychloroquine where the initial hype and misinformation lead to shortages, price rises and suicides. Price rises and shortages have also been seen for PPE. Such activities can have catastrophic effects on patients where there are high co-payment levels and issues of affordability. Consequently, there is a need to investigate this further. Objective: Assess changes in the availability, utilization and prices of relevant medicines and PPE during the pandemic among a range of Asian countries. Our approach: Narrative literature review combined with interviews among community pharmacists to assess changes in consumption, prices and shortages of medicines and PPE from the beginning of March 2020 until end of May 2020. In addition, suggestions on ways to reduce misinformation. Results: 308 pharmacists took part from five Asian countries. There was an appreciable increase in the utilization of antimicrobials in Pakistan (in over 88% of pharmacies), with lower increases or no change in Bangladesh, India, Malaysia and Vietnam. Encouragingly, there was increased use of vitamins/immune boosters and PPE across the countries, as well as limited price rises for antimicrobials in India, Malaysia and Vietnam, although greater price rises seen for analgesics and vitamin C/immune boosters. Appreciable price increases were also seen for PPE across some countries. Conclusion: Encouraging to see increases in utilization of vitamins/immune boosters and PPE. However, increases in the utilization and prices of antimicrobials is a concern that needs addressing alongside misinformation and any unintended consequences from the pandemic. Community pharmacists can play a key role in providing evidence-based advice, helping to moderate prices, as well as helping address some of the unintended consequences of the pandemic.", "doi": "10.3389/fpubh.2020.585832", "pmid": "33381485", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7767884"}, {"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-07T12:08:28.441Z", "modified": "2021-02-26T08:46:59.826Z"}, {"entity": "publication", "iuid": "31fa7f460b4b485b93fa9345954bb9ea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/31fa7f460b4b485b93fa9345954bb9ea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/31fa7f460b4b485b93fa9345954bb9ea"}}, "title": "Covid-19: Sweden considers tougher restrictions as ICU beds near capacity.", "authors": [{"family": "Paterlini", "given": "Marta", "initials": "M"}], "type": "journal article", "published": "2020-12-14", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "371", "issue": null, "pages": "m4833", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m4833", "pmid": "33318030", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-21T10:16:30.160Z", "modified": "2020-12-21T10:16:30.188Z"}, {"entity": "publication", "iuid": "55331c5e35f74d09a14cbe3534f72131", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/55331c5e35f74d09a14cbe3534f72131.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/55331c5e35f74d09a14cbe3534f72131"}}, "title": "Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features.", "authors": [{"family": "Hassan", "given": "Sk Sarif", "initials": "SS"}, {"family": "Ghosh", "given": "Shinjini", "initials": "S"}, {"family": "Attrish", "given": "Diksha", "initials": "D"}, {"family": "Choudhury", "given": "Pabitra Pal", "initials": "PP"}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA"}, {"family": "Uhal", "given": "Bruce D", "initials": "BD"}, {"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN"}, {"family": "Seyran", "given": "Murat", "initials": "M"}, {"family": "Pizzol", "given": "Damiano", "initials": "D"}, {"family": "Adadi", "given": "Parise", "initials": "P"}, {"family": "Soares", "given": "Antonio", "initials": "A"}, {"family": "El-Aziz", "given": "Tarek Mohamed Abd", "initials": "TMA"}, {"family": "Kandimalla", "given": "Ramesh", "initials": "R"}, {"family": "Tambuwala", "given": "Murtaza M", "initials": "MM"}, {"family": "Azad", "given": "Gajendra Kumar", "initials": "GK"}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Baetas-da-Cruz", "given": "Wagner", "initials": "W"}, {"family": "Takayama", "given": "Kazuo", "initials": "K"}, {"family": "Serrano-Aroca", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "Chauhan", "given": "Gaurav", "initials": "G"}, {"family": "Palu", "given": "Giorgio", "initials": "G"}, {"family": "Brufsky", "given": "Adam M", "initials": "AM"}], "type": "journal article", "published": "2020-12-13", "journal": {"title": "Molecules", "issn": "1420-3049", "volume": "25", "issue": "24", "pages": "5906", "issn-l": null}, "abstract": "Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22-42, aa 79-84, and aa 330-393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species.", "doi": "10.3390/molecules25245906", "pmid": "33322198", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "molecules25245906"}], "notes": [], "created": "2020-12-21T10:03:41.914Z", "modified": "2021-02-26T08:45:48.163Z"}, {"entity": "publication", "iuid": "ba31a9e9933a4ca68a0efcbeb9cad020", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ba31a9e9933a4ca68a0efcbeb9cad020.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ba31a9e9933a4ca68a0efcbeb9cad020"}}, "title": "The role of extracellular DNA in COVID-19: clues from inflamm-aging.", "authors": [{"family": "Storci", "given": "Gianluca", "initials": "G"}, {"family": "Bonifazi", "given": "Francesca", "initials": "F"}, {"family": "Garagnani", "given": "Paolo", "initials": "P"}, {"family": "Olivieri", "given": "Fabiola", "initials": "F"}, {"family": "Bonaf\u00e8", "given": "Massimiliano", "initials": "M"}], "type": "journal article", "published": "2020-12-12", "journal": {"title": "Ageing Res Rev", "issn": "1872-9649", "volume": "66", "issue": null, "pages": "101234", "issn-l": "1568-1637"}, "abstract": "Epidemiological data convey severe prognosis and high mortality rate for COVID-19 in elderly men affected by age-related diseases. These subjects develop local and systemic hyper-inflammation, which are associated with thrombotic complications and multi-organ failure. Therefore, understanding SARS-CoV-2 induced hyper-inflammation in elderly men is a pressing need. Here we focus on the role of extracellular DNA, mainly mitochondrial DNA (mtDNA) and telomeric DNA (telDNA) in the modulation of systemic inflammation in these subjects. In particular, extracellular mtDNA is regarded as a powerful trigger of the inflammatory response. On the contrary, extracellular telDNA pool is estimated to be capable of inhibiting a variety of inflammatory pathways. In turn, we underpin that telDNA reservoir is progressively depleted during aging, and that it is scarcer in men than in women. We propose that an increase in extracellular mtDNA, concomitant with the reduction of the anti-inflammatory telDNA reservoir may explain hyper-inflammation in elderly male affected by COVID-19. This scenario is reminiscent of inflamm-aging, the portmanteau word that depicts how aging and aging related diseases are intimately linked to inflammation.", "doi": "10.1016/j.arr.2020.101234", "pmid": "33321254", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1568-1637(20)30369-X"}], "notes": [], "created": "2020-12-21T10:05:39.471Z", "modified": "2021-01-10T18:17:21.167Z"}, {"entity": "publication", "iuid": "353c836a008149b6b1884eaf9e5c3dcb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/353c836a008149b6b1884eaf9e5c3dcb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/353c836a008149b6b1884eaf9e5c3dcb"}}, "title": "The MERS-CoV receptor gene is among COVID-19 risk factors inherited from Neandertals", "authors": [{"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "Paabo", "given": "Svante", "initials": "S"}], "type": "posted-content", "published": "2020-12-12", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.11.422139", "pmid": null, "labels": {"Type: Preprint": null, "Category: Genomics & transcriptomics": null, "Category: Other": null}, "xrefs": [{"db": "URL", "key": "http://cdna.eva.mpg.de/neandertal/Vindija/VCF/", "description": "Croatian Neandertal genome"}, {"db": "URL", "key": "https://bioinf.eva.mpg.de/jbrowse/", "description": "Croatian Neandertal genome"}, {"db": "URL", "key": "http://ftp.1000genomes.ebi.ac.uk/vol1/ftp/release/20130502/", "description": "Modern human genomes at the 1000 Genomes Project"}, {"db": "URL", "key": "https://www.covid19hg.org/results/", "description": "GWAS summary statistics (round 4 release: A/B2_ALL_eur_leave_23andme)"}], "notes": [], "created": "2021-01-08T08:41:17.454Z", "modified": "2021-02-26T08:46:13.031Z"}, {"entity": "publication", "iuid": "e333d7fb14ef4f8ab958615325a0d36d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e333d7fb14ef4f8ab958615325a0d36d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e333d7fb14ef4f8ab958615325a0d36d"}}, "title": "Home-Based Care for People with Alzheimer's Disease and Related Dementias (ADRD) during COVID-19 Pandemic: From Challenges to Solutions.", "authors": [{"family": "Sm-Rahman", "given": "Atiqur", "initials": "A"}, {"family": "Lo", "given": "Chih Hung", "initials": "CH"}, {"family": "Ramic", "given": "Azra", "initials": "A"}, {"family": "Jahan", "given": "Yasmin", "initials": "Y"}], "type": "journal article", "published": "2020-12-12", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "17", "issue": "24", "pages": "9303", "issn-l": null}, "abstract": "There has been supporting evidence that older adults with underlying health conditions form the majority of the fatal cases in the current novel coronavirus disease (COVID-19) pandemic. While the impact of COVID-19 is affecting the general public, it is clear that these distressful experiences will be magnified in older adults, particularly people living with Alzheimer's disease and related dementia (ADRD), making them the most vulnerable group during this time. People with differing degrees of ADRD are especially susceptible to the virus, not only because of their difficulties in assessing the threat or remembering the safety measures, but also because of the likelihood to be subject to other risk factors, such as lack of proper care and psychological issues. Therefore, in this article, we will discuss the challenges related to home-based care for people with ADRD during a pandemic and propose a formulation of systematic solutions to address these challenges and to alleviate the social and economic impact resulting from the crisis.", "doi": "10.3390/ijerph17249303", "pmid": "33322696", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph17249303"}], "notes": [], "created": "2020-12-21T10:02:09.026Z", "modified": "2021-02-26T08:45:48.802Z"}, {"entity": "publication", "iuid": "e6263b3ecca646cf92defcc715504da1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6263b3ecca646cf92defcc715504da1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6263b3ecca646cf92defcc715504da1"}}, "title": "Will the COVID-19 pandemic lead to a tsunami of suicides? A Swedish nationwide analysis of historical and 2020 data", "authors": [{"family": "R\u00fcck", "given": "Christian", "initials": "C"}, {"family": "Mataix-Cols", "given": "David", "initials": "D"}, {"family": "Malki", "given": "Kinda", "initials": "K"}, {"family": "Adler", "given": "Mats", "initials": "M"}, {"family": "Flygare", "given": "Oskar", "initials": "O"}, {"family": "Runeson", "given": "Bo", "initials": "B"}, {"family": "Sidorchuk", "given": "Anna", "initials": "A"}], "type": "posted-content", "published": "2020-12-11", "journal": {"title": "", "issn": null, "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1101/2020.12.10.20244699", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-09T19:31:08.617Z", "modified": "2021-06-09T19:31:08.617Z"}, {"entity": "publication", "iuid": "ec1877b0d29b4867afe2f155af937d3b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec1877b0d29b4867afe2f155af937d3b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec1877b0d29b4867afe2f155af937d3b"}}, "title": "Virtual and In Vitro Antiviral Screening Revive Therapeutic Drugs for COVID-19", "authors": [{"family": "Bocci", "given": "Giovanni", "initials": "G"}, {"family": "Bradfute", "given": "Steven B", "initials": "SB"}, {"family": "Ye", "given": "Chunyan", "initials": "C"}, {"family": "Garcia", "given": "Matthew J", "initials": "MJ"}, {"family": "Parvathareddy", "given": "Jyothi", "initials": "J"}, {"family": "Reichard", "given": "Walter", "initials": "W"}, {"family": "Surendranathan", "given": "Surekha", "initials": "S"}, {"family": "Bansal", "given": "Shruti", "initials": "S"}, {"family": "Bologa", "given": "Cristian G", "initials": "CG"}, {"family": "Perkins", "given": "Douglas J", "initials": "DJ"}, {"family": "Jonsson", "given": "Colleen B", "initials": "CB"}, {"family": "Sklar", "given": "Larry A", "initials": "LA"}, {"family": "Oprea", "given": "Tudor I", "initials": "TI"}], "type": "journal-article", "published": "2020-12-11", "journal": {"title": "ACS Pharmacol. Transl. Sci.", "issn": "2575-9108", "issn-l": null, "volume": "3", "issue": "6", "pages": "1278-1292"}, "abstract": "The urgent need for a cure for early phase COVID-19 infected patients critically underlines drug repositioning strategies able to efficiently identify new and reliable treatments by merging computational, experimental, and pharmacokinetic expertise. Here we report new potential therapeutics for COVID-19 identified with a combined virtual and experimental screening strategy and selected among already approved drugs. We used hydroxychloroquine (HCQ), one of the most studied drugs in current clinical trials, as a reference template to screen for structural similarity against a library of almost 4000 approved drugs. The top-ranked drugs, based on structural similarity to HCQ, were selected for in vitro antiviral assessment. Among the selected drugs, both zuclopenthixol and nebivolol efficiently block SARS-CoV-2 infection with EC50 values in the low micromolar range, as confirmed by independent experiments. The anti-SARS-CoV-2 potential of ambroxol, amodiaquine, and its active metabolite (N-monodesethyl amodiaquine) is also discussed. In trying to understand the \"hydroxychloroquine\" mechanism of action, both pKa and the HCQ aromatic core may play a role. Further, we show that the amodiaquine metabolite and, to a lesser extent, zuclopenthixol and nebivolol are active in a SARS-CoV-2 titer reduction assay. Given the need for improved efficacy and safety, we propose zuclopenthixol, nebivolol, and amodiaquine as potential candidates for clinical trials against the early phase of the SARS-CoV-2 infection and discuss their potential use as adjuvant to the current (i.e., remdesivir and favipiravir) COVID-19 therapeutics.", "doi": "10.1021/acsptsci.0c00131", "pmid": "33330842", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-01-10T18:12:02.890Z", "modified": "2021-02-26T08:45:25.930Z"}, {"entity": "publication", "iuid": "8f4719a29b274ec78a4692ec6e333afe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f4719a29b274ec78a4692ec6e333afe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f4719a29b274ec78a4692ec6e333afe"}}, "title": "Thermal inactivation of COVID-19 specimens improves RNA quality and quantity.", "authors": [{"family": "Hemati", "given": "Maral", "initials": "M"}, {"family": "Soosanabadi", "given": "Mohsen", "initials": "M"}, {"family": "Ghorashi", "given": "Tahereh", "initials": "T"}, {"family": "Ghaffari", "given": "Hadi", "initials": "H"}, {"family": "Vahedi", "given": "Azadeh", "initials": "A"}, {"family": "Sabbaghian", "given": "Elaheh", "initials": "E"}, {"family": "Rasouli Nejad", "given": "Zahra", "initials": "Z"}, {"family": "Salati", "given": "Amir", "initials": "A"}, {"family": "Danaei", "given": "Navid", "initials": "N"}, {"family": "Kokhaei", "given": "Parviz", "initials": "P"}], "type": "journal article", "published": "2020-12-11", "journal": {"title": "J Cell Physiol", "issn": "1097-4652", "volume": null, "issue": null, "issn-l": null}, "abstract": "The rapid spread of coronavirus disease 2019 (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2, poses a huge demand for immediate diagnosis. Real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) of nasopharyngeal (NP) and oropharyngeal (OP) swabs have been used to confirm the clinical diagnosis. To avoid the risk of viral-exposure of laboratory workers, thermal inactivation is currently recommended but has unknown effects on the accuracy of the rRT-PCR results. Thirty-six NP/OP specimens were collected from COVID-19 patients and subjected to thermal inactivation (60\u00b0C for 30 min) or the RNA extraction processes to activate the form. Here, our data showed that the concentration of extracted-RNA increases upon thermal inactivation compared to the active form (p = .028). Significantly higher levels of RNA copy number were obtained in inactivated compared to the active samples for both N and ORF1ab genes (p = .009, p = .032, respectively). Thermal inactivation elevated concentration and copy number of extracted-RNA, possibly through viral-capsid degradation and/or nucleoprotein denaturation.", "doi": "10.1002/jcp.30206", "pmid": "33305832", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "NA", "key": "All data is included in the paper", "description": null}], "notes": [], "created": "2020-12-13T07:09:52.986Z", "modified": "2021-11-18T10:50:34.005Z"}, {"entity": "publication", "iuid": "436a8679ea6f4aabb1a29e5b881218c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/436a8679ea6f4aabb1a29e5b881218c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/436a8679ea6f4aabb1a29e5b881218c5"}}, "title": "SARS-CoV-2 genome diversity at the binding sites of oligonucleotides used for COVID-19 diagnosis", "authors": [{"family": "Valieris", "given": "Renan", "initials": "R"}, {"family": "Kowaslki", "given": "Michal", "initials": "M"}, {"family": "Frolova", "given": "Alina", "initials": "A"}, {"family": "Wydmanski", "given": "Witold", "initials": "W"}, {"family": "Foox", "given": "Johnathan", "initials": "J"}, {"family": "Torrezan", "given": "Giovana", "initials": "G"}, {"family": "Pospiech", "given": "Ewelina", "initials": "E"}, {"family": "Branicki", "given": "Wojciech", "initials": "W"}, {"family": "Venkateswaran", "given": "Kasthuri", "initials": "K"}, {"family": "Prithiviraj", "given": "Bharath", "initials": "B"}, {"family": "Dhamodharan", "given": "Ramasamy", "initials": "R"}, {"family": "Udekwu", "given": "Klas", "initials": "K"}, {"family": "Nunes", "given": "Diana", "initials": "D"}, {"family": "Carraro", "given": "Dirce", "initials": "D"}, {"family": "Mason", "given": "Christopher", "initials": "C"}, {"family": "Labaj", "given": "Pawel", "initials": "P"}, {"family": "Silva", "given": "Israel", "initials": "I"}, {"family": "Dias-Neto", "given": "Emmanuel", "initials": "E"}], "type": "posted-content", "published": "2020-12-11", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.10.20236943", "pmid": null, "labels": {"Category: Genomics & transcriptomics": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2020-12-13T07:59:44.049Z", "modified": "2021-03-10T15:25:26.218Z"}, {"entity": "publication", "iuid": "9464140b8b6d4cc6b78280e9bf8d918b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9464140b8b6d4cc6b78280e9bf8d918b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9464140b8b6d4cc6b78280e9bf8d918b"}}, "title": "Picomolar SARS-CoV-2 Neutralization Using Multi-Arm PEG Nanobody Constructs.", "authors": [{"family": "Moliner-Morro", "given": "Ainhoa", "initials": "A"}, {"family": "J Sheward", "given": "Daniel", "initials": "D"}, {"family": "Karl", "given": "Vivien", "initials": "V"}, {"family": "Perez Vidakovics", "given": "Laura", "initials": "L"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}, {"family": "Hanke", "given": "Leo", "initials": "L"}], "type": "journal article", "published": "2020-12-11", "journal": {"title": "Biomolecules", "issn": "2218-273X", "issn-l": null, "volume": "10", "issue": "12", "pages": null}, "abstract": "Multivalent antibody constructs have a broad range of clinical and biotechnological applications. Nanobodies are especially useful as components for multivalent constructs as they allow increased valency while maintaining a small molecule size. We here describe a novel, rapid method for the generation of bi- and multivalent nanobody constructs with oriented assembly by Cu-free strain promoted azide-alkyne click chemistry (SPAAC). We used sortase A for ligation of click chemistry functional groups site-specifically to the C-terminus of nanobodies before creating C-to-C-terminal nanobody fusions and 4-arm polyethylene glycol (PEG) tetrameric nanobody constructs. We demonstrated the viability of this approach by generating constructs with the SARS-CoV-2 neutralizing nanobody Ty1. We compared the ability of the different constructs to neutralize SARS-CoV-2 pseudotyped virus and infectious virus in neutralization assays. The generated dimers neutralized the virus similarly to a nanobody-Fc fusion variant, while a 4-arm PEG based tetrameric Ty1 construct dramatically enhanced neutralization of SARS-CoV-2, with an IC 50 in the low picomolar range.", "doi": "10.3390/biom10121661", "pmid": "33322557", "labels": {"Type: Journal article": null, "Funder: H2020": null, "Funder: VR: Special COVID-19 funding": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Proteins": null}, "xrefs": [{"db": "pii", "key": "biom10121661"}], "notes": [], "created": "2020-12-18T07:54:12.206Z", "modified": "2021-02-26T08:47:18.845Z"}, {"entity": "publication", "iuid": "ddbdaab95394488cbf53747695bea4e4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ddbdaab95394488cbf53747695bea4e4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ddbdaab95394488cbf53747695bea4e4"}}, "title": "Genetic mechanisms of critical illness in Covid-19.", "authors": [{"family": "Pairo-Castineira", "given": "Erola", "initials": "E"}, {"family": "Clohisey", "given": "Sara", "initials": "S"}, {"family": "Klaric", "given": "Lucija", "initials": "L"}, {"family": "Bretherick", "given": "Andrew D", "initials": "AD"}, {"family": "Rawlik", "given": "Konrad", "initials": "K"}, {"family": "Pasko", "given": "Dorota", "initials": "D"}, {"family": "Walker", "given": "Susan", "initials": "S"}, {"family": "Parkinson", "given": "Nick", "initials": "N"}, {"family": "Fourman", "given": "Max Head", "initials": "MH"}, {"family": "Russell", "given": "Clark D", "initials": "CD"}, {"family": "Furniss", "given": "James", "initials": "J"}, {"family": "Richmond", "given": "Anne", "initials": "A"}, {"family": "Gountouna", "given": "Elvina", "initials": "E"}, {"family": "Wrobel", "given": "Nicola", "initials": "N"}, {"family": "Harrison", "given": "David", "initials": "D"}, {"family": "Wang", "given": "Bo", "initials": "B"}, {"family": "Wu", "given": "Yang", "initials": "Y"}, {"family": "Meynert", "given": "Alison", "initials": "A"}, {"family": "Griffiths", "given": "Fiona", "initials": "F"}, {"family": "Oosthuyzen", "given": "Wilna", "initials": "W"}, {"family": "Kousathanas", "given": "Athanasios", "initials": "A"}, {"family": "Moutsianas", "given": "Loukas", "initials": "L"}, {"family": "Yang", "given": "Zhijian", "initials": "Z"}, {"family": "Zhai", "given": "Ranran", "initials": "R"}, {"family": "Zheng", "given": "Chenqing", "initials": "C"}, {"family": "Grimes", "given": "Graeme", "initials": "G"}, {"family": "Beale", "given": "Rupert", "initials": "R"}, {"family": "Millar", "given": "Jonathan", "initials": "J"}, {"family": "Shih", "given": "Barbara", "initials": "B"}, {"family": "Keating", "given": "Sean", "initials": "S"}, {"family": "Zechner", "given": "Marie", "initials": "M"}, {"family": "Haley", "given": "Chris", "initials": "C"}, {"family": "Porteous", "given": "David J", "initials": "DJ"}, {"family": "Hayward", "given": "Caroline", "initials": "C"}, {"family": "Yang", "given": "Jian", "initials": "J"}, {"family": "Knight", "given": "Julian", "initials": "J"}, {"family": "Summers", "given": "Charlotte", "initials": "C"}, {"family": "Shankar-Hari", "given": "Manu", "initials": "M"}, {"family": "Klenerman", "given": "Paul", "initials": "P"}, {"family": "Turtle", "given": "Lance", "initials": "L"}, {"family": "Ho", "given": "Antonia", "initials": "A"}, {"family": "Moore", "given": "Shona C", "initials": "SC"}, {"family": "Hinds", "given": "Charles", "initials": "C"}, {"family": "Horby", "given": "Peter", "initials": "P"}, {"family": "Nichol", "given": "Alistair", "initials": "A"}, {"family": "Maslove", "given": "David", "initials": "D"}, {"family": "Ling", "given": "Lowell", "initials": "L"}, {"family": "McAuley", "given": "Danny", "initials": "D"}, {"family": "Montgomery", "given": "Hugh", "initials": "H"}, {"family": "Walsh", "given": "Timothy", "initials": "T"}, {"family": "Pereira", "given": "Alex", "initials": "A"}, {"family": "Renieri", "given": "Alessandra", "initials": "A"}, {"family": "GenOMICC Investigators", "given": "", "initials": ""}, {"family": "ISARICC Investigators", "given": "", "initials": ""}, {"family": "COVID-19 Human Genetics Initiative", "given": "", "initials": ""}, {"family": "23andMe Investigators", "given": "", "initials": ""}, {"family": "BRACOVID Investigators", "given": "", "initials": ""}, {"family": "Gen-COVID Investigators", "given": "", "initials": ""}, {"family": "Shen", "given": "Xia", "initials": "X"}, {"family": "Ponting", "given": "Chris P", "initials": "CP"}, {"family": "Fawkes", "given": "Angie", "initials": "A"}, {"family": "Tenesa", "given": "Albert", "initials": "A"}, {"family": "Caulfield", "given": "Mark", "initials": "M"}, {"family": "Scott", "given": "Richard", "initials": "R"}, {"family": "Rowan", "given": "Kathy", "initials": "K"}, {"family": "Murphy", "given": "Lee", "initials": "L"}, {"family": "Openshaw", "given": "Peter J M", "initials": "PJM"}, {"family": "Semple", "given": "Malcolm G", "initials": "MG"}, {"family": "Law", "given": "Andrew", "initials": "A"}, {"family": "Vitart", "given": "Veronique", "initials": "V"}, {"family": "Wilson", "given": "James F", "initials": "JF"}, {"family": "Baillie", "given": "J Kenneth", "initials": "JK"}], "type": "journal article", "published": "2020-12-11", "journal": {"title": "Nature", "issn": "1476-4687", "volume": null, "issue": null, "issn-l": "0028-0836"}, "abstract": "Host-mediated lung inflammation is present, 1 and drives mortality,2 in critical illness caused by Covid-19. Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development.3 Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study(GWAS) in 2244 critically ill Covid-19 patients from 208 UK intensive care units (ICUs). We identify and replicate novel genome-wide significant associations, on chr12q24.13 (rs10735079, p=1.65 [Formula: see text] 10-8) in a gene cluster encoding antiviral restriction enzyme activators (OAS1, OAS2, OAS3), on chr19p13.2 (rs2109069, p=2.3 [Formula: see text] 10-12) near the gene encoding tyrosine kinase 2 (TYK2), on chr19p13.3 (rs2109069, p=3.98 [Formula: see text] 10-12) within the gene encoding dipeptidyl peptidase 9 (DPP9), and on chr21q22.1 (rs2236757, p=4.99 [Formula: see text] 10-8) in the interferon receptor gene IFNAR2. We identify potential targets for repurposing of licensed medications: using Mendelian randomisation we found evidence in support of a causal link from low expression of IFNAR2, and high expression of TYK2, to life-threatening disease; transcriptome-wide association in lung tissue revealed that high expression of the monocyte/macrophage chemotactic receptor CCR2 is associated with severe Covid-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms, and mediators of inflammatory organ damage in Covid-19. Both mechanisms may be amenable to targeted treatment with existing drugs. Large-scale randomised clinical trials will be essential before any change to clinical practice.", "doi": "10.1038/s41586-020-03065-y", "pmid": "33307546", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null}, "xrefs": [], "notes": [], "created": "2020-12-13T07:06:59.152Z", "modified": "2021-02-26T08:45:14.476Z"}, {"entity": "publication", "iuid": "7fe2976d7ac044c290eda708d6c87267", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7fe2976d7ac044c290eda708d6c87267.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7fe2976d7ac044c290eda708d6c87267"}}, "title": "Serum neopterin levels in relation to mild and severe COVID-19", "authors": [{"family": "Robertson", "given": "Josefina", "initials": "J"}, {"family": "Gostner", "given": "Johanna M", "initials": "JM"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "L"}, {"family": "Fuchs", "given": "Dietmar", "initials": "D"}, {"family": "Gisslen", "given": "Magnus", "initials": "M"}], "type": "posted-content", "published": "2020-12-10", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "issn-l": null, "volume": "Dec 10; 20", "issue": "1", "pages": "942"}, "abstract": "Background The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, is rapidly spreading worldwide. There is limited information about prognostic markers that could help clinicians to identify COVID-19 patients with a poor prognosis. Serum levels of the immune activation marker neopterin has shown to be of prognostic value in patients with SARS. The aim of this study was to investigate whether serum neopterin is associated with the severity of COVID-19. Methods We included 34 patients with confirmed COVID-19 between March 3 and March 30, 2020. Fifteen patients had mild disease and did not require hospitalization, whereas 19 patients developed severe COVID-19 requiring intensive care. Concentrations of serum neopterin, tryptophan, and kynurenine were measured at and repeatedly after inclusion. Results We found a more than two-fold higher mean concentration of neopterin in severely ill patients (mean value 42.0 nmol/L (SD 18.2)) compared to patients with mild symptoms (16.9 nmol/L (SD 11.0)). All of the severe cases had elevated neopterin concentrations (>9.1 nmol/L) at the initial sampling with values ranging from 17.2 to 86.7 nmol/L. In comparison, 10 of 15 patients with mild disease had neopterin levels above 9.1 nmol/L, with concentrations in the range from 4.9 to 31.6 nmol/L. Neopterin levels gradually decreased during the course of COVID-19, but severe cases maintained elevated levels for a longer period. Moreover, lower levels of tryptophan and higher levels of kynurenine, indicating an increased tryptophan catabolism, were seen in the group with severe cases. Conclusions In conclusion, we found that serum neopterin levels are associated with the severity of COVID-19. Our findings suggest that neopterin could be used as a prognostic marker, but further studies are needed to elucidate how it can be used in clinical praxis.", "doi": "10.1186/s12879-020-05671-7", "pmid": "33302893", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Research Area: Biomarkers and systems immunology": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-10-30T11:40:52.446Z", "modified": "2021-06-13T05:56:58.395Z"}, {"entity": "publication", "iuid": "d3008d631eca40d0be03bf85943fe585", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3008d631eca40d0be03bf85943fe585.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3008d631eca40d0be03bf85943fe585"}}, "title": "Public perceptions of multiple risks during the COVID-19 pandemic in Italy and Sweden.", "authors": [{"family": "Mondino", "given": "Elena", "initials": "E"}, {"family": "Di Baldassarre", "given": "Giuliano", "initials": "G"}, {"family": "M\u00e5rd", "given": "Johanna", "initials": "J"}, {"family": "Ridolfi", "given": "Elena", "initials": "E"}, {"family": "Rusca", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2020-12-10", "journal": {"title": "Sci Data", "issn": "2052-4463", "volume": "7", "issue": "1", "pages": "434", "issn-l": null}, "abstract": "Knowing how people perceive multiple risks is essential to the management and promotion of public health and safety. Here we present a dataset based on a survey (N = 4,154) of public risk perception in Italy and Sweden during the COVID-19 pandemic. Both countries were heavily affected by the first wave of infections in Spring 2020, but their governmental responses were very different. As such, the dataset offers unique opportunities to investigate the role of governmental responses in shaping public risk perception. In addition to epidemics, the survey considered indirect effects of COVID-19 (domestic violence, economic crises), as well as global (climate change) and local (wildfires, floods, droughts, earthquakes, terror attacks) threats. The survey examines perceived likelihoods and impacts, individual and authorities' preparedness and knowledge, and socio-demographic indicators. Hence, the resulting dataset has the potential to enable a plethora of analyses on social, cultural and institutional factors influencing the way in which people perceive risk.", "doi": "10.1038/s41597-020-00778-7", "pmid": "33303742", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41597-020-00778-7"}, {"db": "URL", "key": "https://doi.org/10.5281/zenodo.4034276", "description": "Raw dataset: perceived likelihoods and impacts, individual and authorities\u2019 preparedness and knowledge, socio-demographic characteristics (N=2,033 in Italy, N=2,121 in Sweden)"}], "notes": [], "created": "2020-12-13T07:21:54.602Z", "modified": "2021-02-26T08:47:00.220Z"}, {"entity": "publication", "iuid": "d8a6f0a2b02147618996bed9adb324bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d8a6f0a2b02147618996bed9adb324bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d8a6f0a2b02147618996bed9adb324bf"}}, "title": "Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses", "authors": [{"family": "Tampere", "given": "Marianna", "initials": "M"}, {"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Salata", "given": "Cristiano", "initials": "C"}, {"family": "Wallner", "given": "Olov", "initials": "O"}, {"family": "Koolmeister", "given": "Tobias", "initials": "T"}, {"family": "Cazares-K\u00f6rner", "given": "Armando", "initials": "A"}, {"family": "Visnes", "given": "Torkild", "initials": "T"}, {"family": "Hesselman", "given": "Maria Carmen", "initials": "MC"}, {"family": "Kunold", "given": "Elena", "initials": "E"}, {"family": "Wiita", "given": "Elisee", "initials": "E"}, {"family": "Kalder\u00e9n", "given": "Christina", "initials": "C"}, {"family": "Lightowler", "given": "Molly", "initials": "M"}, {"family": "Jemth", "given": "Ann Sofie", "initials": "AS"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J"}, {"family": "Rosenquist", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Warpman-Berglund", "given": "Ulrika", "initials": "U"}, {"family": "Helleday", "given": "Thomas", "initials": "T"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Jafari", "given": "Rozbeh", "initials": "R"}, {"family": "Puumalainen", "given": "Marjo Riitta", "initials": "MR"}], "type": "journal-article", "published": "2020-12-10", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "12", "issue": "12", "pages": "1423"}, "abstract": null, "doi": "10.3390/v12121423", "pmid": null, "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Category: Drug Discovery": null, "Category: Proteins": null}, "xrefs": [{"db": "URL", "key": "https://www.mdpi.com/1999-4915/12/12/1423/s1", "description": "Antiviral screening; Dose-response treatment of TH6744 and TH3289; List of proteins from 2D-TPP analysis in U87 cells (FDR); List of proteins from 2D-TPP analysis in U87 cells (Fold-change); Uniprot annotation of overlapping TPP-TR and 2D-TPP hits"}, {"db": "URL", "key": "https://doi.org/10.17044/scilifelab.13089023", "description": "Thermal Proteome Profiling dataset from Hazara virus infected SW13 cells"}, {"db": "URL", "key": "http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD021494", "description": "Raw mass spectrometry data were deposited in the ProteomeXchange Consortium (accession: PXD021494)"}], "notes": [], "created": "2020-12-15T10:44:22.469Z", "modified": "2021-11-18T10:43:13.213Z"}, {"entity": "publication", "iuid": "da568203ba764ebf94e393dfa8ffe7f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/da568203ba764ebf94e393dfa8ffe7f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/da568203ba764ebf94e393dfa8ffe7f9"}}, "title": "Variable sensitivity in molecular detection of SARS-CoV-2 in European Expert Laboratories: External Quality Assessment, June - July 2020.", "authors": [{"family": "Fischer", "given": "Carlo", "initials": "C"}, {"family": "M\u00f6gling", "given": "Ramona", "initials": "R"}, {"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "K\u00fchne", "given": "Arne", "initials": "A"}, {"family": "Oliveira-Filho", "given": "Edmilson F", "initials": "EF"}, {"family": "Wolff", "given": "Thorsten", "initials": "T"}, {"family": "Reiche", "given": "Janine", "initials": "J"}, {"family": "Broberg", "given": "Eeva", "initials": "E"}, {"family": "Meijer", "given": "Adam", "initials": "A"}, {"family": "Leitmeyer", "given": "Katrin", "initials": "K"}, {"family": "Drexler", "given": "Jan Felix", "initials": "JF"}, {"family": "Reusken", "given": "Chantal B E M", "initials": "CBEM"}], "type": "journal article", "published": "2020-12-09", "journal": {"title": "J Clin Microbiol", "issn": "1098-660X", "volume": null, "issue": null, "issn-l": null}, "abstract": "Objective: During the ongoing coronavirus disease 2019 (COVID-19) outbreak, robust detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a key element for clinical management and to interrupt transmission chains. We organized an external quality assessment (EQA) of molecular detection of SARS-CoV-2 for European expert laboratories.Study design: An EQA panel composed of 12 samples, containing either SARS-CoV-2 at different concentrations to evaluate sensitivity or other respiratory viruses to evaluate specificity of SARS-CoV-2 testing, was distributed to 68 laboratories in 35 countries. Specificity samples included seasonal human coronaviruses hCoV-229E, hCoV-NL63 and hCoV-OC43, as well as MERS-CoV, SARS-CoV and human influenza virus A and B.Conclusion: Sensitivity was variable among laboratories, particularly for low concentration SARS-CoV-2 samples. Results indicated that performance was mostly independent of the selection of specific extraction or PCR methods.", "doi": "10.1128/JCM.02676-20", "pmid": "33298612", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "JCM.02676-20"}], "notes": [], "created": "2020-12-21T10:24:12.977Z", "modified": "2020-12-21T10:24:18.568Z"}, {"entity": "publication", "iuid": "7bc8cd7ed5a147eaad1edb24379e7c5a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7bc8cd7ed5a147eaad1edb24379e7c5a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7bc8cd7ed5a147eaad1edb24379e7c5a"}}, "title": "SARS-CoV-2 Spike protein binds to bacterial lipopolysaccharide and boosts proinflammatory activity.", "authors": [{"family": "Petruk", "given": "Ganna", "initials": "G"}, {"family": "Puthia", "given": "Manoj", "initials": "M"}, {"family": "Petrlova", "given": "Jitka", "initials": "J"}, {"family": "Samsudin", "given": "Firdaus", "initials": "F"}, {"family": "Str\u00f6mdahl", "given": "Ann-Charlotte", "initials": "A"}, {"family": "Cerps", "given": "Samuel", "initials": "S"}, {"family": "Uller", "given": "Lena", "initials": "L"}, {"family": "Kjellstr\u00f6m", "given": "Sven", "initials": "S"}, {"family": "Bond", "given": "Peter J", "initials": "PJ"}, {"family": "Schmidtchen", "given": "Artur", "initials": "A"}], "type": "journal article", "published": "2020-12-09", "journal": {"title": "J Mol Cell Biol", "issn": "1759-4685", "issn-l": null, "volume": "12", "issue": "12", "pages": "916-932"}, "abstract": "There is a link between high lipopolysaccharide (LPS) levels in the blood and the metabolic syndrome, and metabolic syndrome predisposes patients to severe COVID-19. Here, we define an interaction between SARS-CoV-2 Spike (S) protein and LPS, leading to aggravated inflammation in vitro and in vivo. Native gel electrophoresis demonstrated that SARS-CoV-2 S protein binds to LPS. Microscale thermophoresis yielded a KD of \u223c47 nM for the interaction. Computational modeling and all-atom molecular dynamics simulations further substantiated the experimental results, identifying a main LPS binding site in SARS-CoV-2 S protein. S protein, when combined with low levels of LPS, boosted nuclear factor-kappa B (NF-\u03baB) activation in monocytic THP-1 cells and cytokine responses in human blood and peripheral blood mononuclear cells, respectively. The in vitro inflammatory response was further validated by employing NF-\u03baB reporter mice and in vivo bioimaging. Dynamic light scattering, transmission electron microscopy, and LPS-FITC analyses demonstrated that S protein modulated the aggregation state of LPS, providing a molecular explanation for the observed boosting effect. Taken together, our results provide an interesting molecular link between excessive inflammation during infection with SARS-CoV-2 and comorbidities involving increased levels of bacterial endotoxins.", "doi": "10.1093/jmcb/mjaa067", "pmid": "33295606", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "6028992"}], "notes": [], "created": "2020-12-10T09:10:19.161Z", "modified": "2021-04-23T14:37:52.421Z"}, {"entity": "publication", "iuid": "cc5b5a5b202d4a13a3a6e430695e4976", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc5b5a5b202d4a13a3a6e430695e4976.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc5b5a5b202d4a13a3a6e430695e4976"}}, "title": "Positive correlation between long term emission of several air pollutants and COVID-19 deaths in Sweden", "authors": [{"family": "Helander", "given": "Lars", "initials": "L"}], "type": "posted-content", "published": "2020-12-09", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.05.20244418", "pmid": null, "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-03-25T14:03:24.020Z", "modified": "2021-03-29T10:10:22.147Z"}, {"entity": "publication", "iuid": "d4e70020cceb46fab1a1a5d44e34e9ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4e70020cceb46fab1a1a5d44e34e9ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4e70020cceb46fab1a1a5d44e34e9ae"}}, "title": "Public health emergencies of international concern: a historic overview.", "authors": [{"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Osman", "given": "Sarah", "initials": "S"}], "type": "journal article", "published": "2020-12-08", "journal": {"title": "J Travel Med", "issn": "1708-8305", "volume": "27", "issue": "8", "issn-l": null}, "abstract": "The International Health Regulations (IHR) have been the governing framework for global health security since 2007. Declaring public health emergencies of international concern (PHEIC) is a cornerstone of the IHR. Here we review how PHEIC are formally declared, the diseases for which such declarations have been made from 2007 until 2020 and justifications for such declarations.\n\nSix events were declared PHEIC between 2007 and 2020: the 2009 H1N1 influenza pandemic, Ebola (West African outbreak 2013-2015, outbreak in Democratic Republic of Congo 2018-2020), poliomyelitis (2014 to present), Zika (2016) and COVID-19 (2020 to present). Poliomyelitis is the longest PHEIC. Zika was the first PHEIC for an arboviral disease. For several other emerging diseases a PHEIC was not declared despite the fact that the public health impact of the event was considered serious and associated with potential for international spread.\n\nThe binary nature of a PHEIC declaration is often not helpful for events where a tiered or graded approach is needed. The strength of PHEIC declarations is the ability to rapidly mobilize international coordination, streamline funding and accelerate the advancement of the development of vaccines, therapeutics and diagnostics under emergency use authorization. The ultimate purpose of such declaration is to catalyse timely evidence-based action, to limit the public health and societal impacts of emerging and re-emerging disease risks while preventing unwarranted travel and trade restrictions.", "doi": "10.1093/jtm/taaa227", "pmid": "33284964", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "6025447"}], "notes": [], "created": "2020-12-10T09:16:43.061Z", "modified": "2021-01-22T09:25:37.994Z"}, {"entity": "publication", "iuid": "a5bc184f74d94abaaf2126638eb17ffa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a5bc184f74d94abaaf2126638eb17ffa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a5bc184f74d94abaaf2126638eb17ffa"}}, "title": "Protective role of tacrolimus, deleterious role of age and comorbidities in liver transplant recipients with Covid-19: results from the ELITA/ELTR multi-center European study.", "authors": [{"family": "Belli", "given": "Luca S", "initials": "LS"}, {"family": "Fondevila", "given": "Constantino", "initials": "C"}, {"family": "Cortesi", "given": "Paolo A", "initials": "PA"}, {"family": "Conti", "given": "Sara", "initials": "S"}, {"family": "Karam", "given": "Vincent", "initials": "V"}, {"family": "Adam", "given": "Rene", "initials": "R"}, {"family": "Coilly", "given": "Audrey", "initials": "A"}, {"family": "Ericzon", "given": "Bo Goran", "initials": "BG"}, {"family": "Loinaz", "given": "Carmelo", "initials": "C"}, {"family": "Cuervas-Mons", "given": "Valentin", "initials": "V"}, {"family": "Zambelli", "given": "Marco", "initials": "M"}, {"family": "Llado", "given": "Laura", "initials": "L"}, {"family": "Diaz", "given": "Fernando", "initials": "F"}, {"family": "Invernizzi", "given": "Federica", "initials": "F"}, {"family": "Patrono", "given": "Damiano", "initials": "D"}, {"family": "Faitot", "given": "Francois", "initials": "F"}, {"family": "Bhooori", "given": "Sherrie", "initials": "S"}, {"family": "Pirenne", "given": "Jacques", "initials": "J"}, {"family": "Perricone", "given": "Giovanni", "initials": "G"}, {"family": "Magini", "given": "Giulia", "initials": "G"}, {"family": "Castells", "given": "LLuis", "initials": "L"}, {"family": "Detry", "given": "Oliver", "initials": "O"}, {"family": "Cruchaga", "given": "Pablo Mart", "initials": "PM"}, {"family": "Colmenero", "given": "Jordi", "initials": "J"}, {"family": "Berrevoet", "given": "Frederick", "initials": "F"}, {"family": "Rodriguez", "given": "Gonzalo", "initials": "G"}, {"family": "Ysebaert", "given": "Dirk", "initials": "D"}, {"family": "Radenne", "given": "Sylvie", "initials": "S"}, {"family": "Metselaar", "given": "Herold", "initials": "H"}, {"family": "Morelli", "given": "Cristina", "initials": "C"}, {"family": "De Carlis", "given": "Luciano", "initials": "L"}, {"family": "Polak", "given": "Wojciech G", "initials": "WG"}, {"family": "Duvoux", "given": "Christophe", "initials": "C"}, {"family": "all the centres contributing to the ELITA-ELTR COVID-19 Registry", "given": "", "initials": ""}], "type": "journal article", "published": "2020-12-08", "journal": {"title": "Gastroenterology", "issn": "1528-0012", "volume": null, "issue": null, "issn-l": null}, "abstract": "Despite concerns that liver transplant (LT) recipients may be at increased risk of unfavorable outcomes from COVID-19 due the high prevalence of co-morbidities, immunosuppression and ageing, a detailed analysis of their effects in large studies is lacking METHODS: Data from adult LT recipients with laboratory confirmed SARS-CoV2 infection were collected across Europe. All consecutive patients with symptoms were included in the analysis, RESULTS: Between March 1st and June 27 th2020, data from 243 adult symptomatic cases from 36 centers and 9 countries were collected. Thirty-nine (16%) were managed as outpatients while 204 (84%) required hospitalization including admission to the ICU (39/204, 19.1%). Forty-nine (20.2%) patients died after a median of 13.5 (10-23) days, respiratory failure was the major cause. After multivariable Cox regression analysis, age > 70 (HR 4.16; 95%CI 1.78-9.73) had a negative effect and tacrolimus (TAC) use (HR 0.55; 95%CI 0.31-0.99) had a positive independent effect on survival. The role of co-morbidities was strongly influenced by the dominant effect of age where comorbidities increased with the increasing age of the recipients. In a second model excluding age, both diabetes (HR 1.95; 95%CI 1.06 - 3.58) and chronic kidney disease (HR 1.97; 95%CI 1.05 - 3.67) emerged as associated with death CONCLUSIONS: Twenty-five per cent of patients requiring hospitalization for Covid-19 died, the risk being higher in patients older than 70 and with medical co-morbidities, such as impaired renal function and diabetes. Conversely, the use of TAC was associated with a better survival thus encouraging clinicians to keep TAC at the usual dose.", "doi": "10.1053/j.gastro.2020.11.045", "pmid": "33307029", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S0016-5085(20)35514-1"}], "notes": [], "created": "2020-12-13T07:08:28.389Z", "modified": "2021-02-26T08:45:03.178Z"}, {"entity": "publication", "iuid": "dd16fa9a8be04f01a74a4ac5d1cd3863", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dd16fa9a8be04f01a74a4ac5d1cd3863.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dd16fa9a8be04f01a74a4ac5d1cd3863"}}, "title": "No impact of cancer and plague-relevant FPR1 polymorphisms on COVID-19.", "authors": [{"family": "Petrazzuolo", "given": "Adriana", "initials": "A"}, {"family": "Le Naour", "given": "Julie", "initials": "J"}, {"family": "Vacchelli", "given": "Erika", "initials": "E"}, {"family": "Gaussem", "given": "Pascale", "initials": "P"}, {"family": "Ellouze", "given": "Syrine", "initials": "S"}, {"family": "Jourdi", "given": "Georges", "initials": "G"}, {"family": "Solary", "given": "Eric", "initials": "E"}, {"family": "Fontenay", "given": "Michaela", "initials": "M"}, {"family": "Smadja", "given": "David M", "initials": "DM"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}], "type": "journal article", "published": "2020-12-08", "journal": {"title": "Oncoimmunology", "issn": "2162-402X", "volume": "9", "issue": "1", "pages": "1857112", "issn-l": "2162-4011"}, "abstract": "Formyl peptide receptor 1 (FPR1) is a pattern-recognition receptor that detects bacterial as well as endogenous danger-associated molecular patterns to trigger innate immune responses by myeloid cells. A single nucleotide polymorphism, rs867228 (allelic frequency 19-20%), in the gene coding for FPR1 accelerates the manifestation of multiple carcinomas, likely due to reduced anticancer immunosurveillance secondary to a defect in antigen presentation by dendritic cells. Another polymorphism in FPR1, rs5030880 (allelic frequency 12-13%), has been involved in the resistance to plague, correlating with the fact that FPR1 is the receptor for Yersinia pestis. Driven by the reported preclinical effects of FPR1 on lung inflammation and fibrosis, we investigated whether rs867228 or rs5030880 would affect the severity of coronavirus disease-19 (COVID-19). Data obtained on patients from two different hospitals in Paris refute the hypothesis that rs867228 or rs5030880 would affect the severity of COVID-19.", "doi": "10.1080/2162402X.2020.1857112", "pmid": "33344044", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "1857112"}, {"db": "pmc", "key": "PMC7734042"}, {"db": "URL", "key": "https://www.tandfonline.com/doi/figure/10.1080/2162402X.2020.1857112?scroll=top&needAccess=true", "description": "Allelic frequencies of FPR1 SNPs and characteristics of patient population from H\u00f4pital Cochin and H\u00f4pital Europ\u00e9en George Pompidou"}], "notes": [], "created": "2021-01-07T09:58:41.553Z", "modified": "2021-11-18T10:35:20.483Z"}, {"entity": "publication", "iuid": "6f826f3022c54f3c9bc2f1833f17a0cd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f826f3022c54f3c9bc2f1833f17a0cd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f826f3022c54f3c9bc2f1833f17a0cd"}}, "title": "Asymptomatic SARS-CoV-2 infection: Is it all about being refractile to innate immune sensing of viral spare-parts? - Clues from exotic animal reservoirs.", "authors": [{"family": "Shankar", "given": "Esaki M", "initials": "EM"}, {"family": "Che", "given": "Karlhans F", "initials": "KF"}, {"family": "Yong", "given": "Yean K", "initials": "YK"}, {"family": "Girija", "given": "A S Smiline", "initials": "ASS"}, {"family": "Velu", "given": "Vijayakumar", "initials": "V"}, {"family": "Ansari", "given": "Abdul W", "initials": "AW"}, {"family": "Larsson", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2020-12-08", "journal": {"title": "Pathog Dis", "issn": "2049-632X", "issn-l": null, "volume": "79", "issue": "1", "pages": null}, "abstract": "A vast proportion of coronavirus disease 2019 (COVID-19) individuals remain asymptomatic and can shed severe acute respiratory syndrome (SARS-CoV) type 2 virus to transmit the infection, which also explains the exponential increase in the number of COVID-19 cases globally. Furthermore, the rate of recovery rates from clinical COVID-19 in certain pockets of the globe is surprisingly high. Based on published reports and available literature, here, we speculated a few immunovirological mechanisms as to why a vast majority of individuals remain asymptomatic similar to exotic animal (bats and pangolins) reservoirs that remain refractile to disease development despite carrying a huge load of diverse insidious viral species, and whether such evolutionary advantage would unveil therapeutic strategies against human COVID-19 infection. Understanding the unique mechanisms that exotic animal species employ to achieve viral control, as well as inflammatory regulation, appears to hold key clues to the development of therapeutic versatility against COVID-19.", "doi": "10.1093/femspd/ftaa076", "pmid": "33289808", "labels": {"Funder: KAW/SciLifeLab": null, "Type: Review": null, "Research Area: Biomarkers and systems immunology": null}, "xrefs": [{"db": "pii", "key": "6027506"}], "notes": [], "created": "2020-12-10T09:14:38.546Z", "modified": "2021-06-13T05:58:21.495Z"}, {"entity": "publication", "iuid": "2e1039d1c30f4e3e969ab8ed6afe7d20", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e1039d1c30f4e3e969ab8ed6afe7d20.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e1039d1c30f4e3e969ab8ed6afe7d20"}}, "title": "Nitric oxide's physiologic effects and potential as a therapeutic agent against COVID-19.", "authors": [{"family": "Ricciardolo", "given": "Fabio Luigi Massimo", "initials": "FLM"}, {"family": "Bertolini", "given": "Francesca", "initials": "F"}, {"family": "Carriero", "given": "Vitina", "initials": "V"}, {"family": "H\u00f6gman", "given": "Marieann", "initials": "M", "orcid": "0000-0002-6392-6092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86cdb5ef5c2e48d886bc443db7f3b64e.json"}}], "type": "journal article", "published": "2020-12-05", "journal": {"title": "J Breath Res", "issn": "1752-7163", "volume": "15", "issue": "1", "pages": "014001", "issn-l": "1752-7155"}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for COVID-19 pneumonia, a pandemic that precipitates huge pressures on the world's social and economic systems. Disease severity varies among individuals. SARS-CoV-2 infection can be associated with e.g. flu-like symptoms, dyspnoea, severe interstitial pneumonia, acute respiratory distress syndrome, multiorgan dysfunction, and generalized coagulopathy. Nitric oxide (NO), is a small signal molecule that impacts pleiotropic functions in human physiology, which can be involved in the significant effects of COVID-19 infection. NO is a neurotransmitter involved in the neural olfactory processes in the central nervous system, and some infected patients have reported anosmia as a symptom. Additionally, NO is a well-known vasodilator, important coagulation mediator, anti-microbial effector and inhibitor of SARS-CoV replication. Exhaled NO is strongly related to the type-2 inflammatory response found in asthma, which has been suggested to be protective against SARS-CoV-2 infection. Several reports indicate that the use of inhaled NO has been an effective therapy during this pandemic since the ventilation-perfusion ratio in COVID-19 patients improved afterwards and they did not require mechanical ventilation. The aim of this mini-review is to summarize relevant actions of NO that could be beneficial in the treatment of COVID-19.", "doi": "10.1088/1752-7163/abc302", "pmid": "33080582", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-19T19:29:57.613Z", "modified": "2023-01-13T13:43:21.870Z"}, {"entity": "publication", "iuid": "e76a6c0b95dc43c883950fbdbb497773", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e76a6c0b95dc43c883950fbdbb497773.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e76a6c0b95dc43c883950fbdbb497773"}}, "title": "Responsible Gambling Telephone Intervention to High-Risk Gamblers by a State-Owned Gambling Operator in Sweden: Study Protocol for a Study on Effectiveness, User Satisfaction, and Acceptability.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "Franklin", "given": "Katja", "initials": "K"}, {"family": "Dahlstr\u00f6m", "given": "Maria", "initials": "M"}, {"family": "Lyckberg", "given": "Axel", "initials": "A"}], "type": "journal article", "published": "2020-12-04", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "17", "issue": "23", "issn-l": null}, "abstract": "Gambling disorder is associated with severe financial, social, and psychological consequences, but treatment-seeking rates have been described to be low. Apart from formal treatment, motivational interventions in nontreatment-seeking high-risk gamblers have been shown to be promising. However, little is known about the effectiveness and acceptability of such motivational interventions carried out by a gambling operator as part of the company's responsible gambling policies. Early experiences of such interventions are limited by the risk that gambling in individuals reached with the intervention may continue with a different gambling operator. The present study aims to evaluate effectiveness and user acceptability of a responsible gambling intervention continuously carried out by the Swedish state-owned gambling operator Svenska Spel Sport & Casino. This intervention for high-risk gamblers, identified either through substantial monetary losses or through a voluntary self-test by the gambler, includes a motivational telephone intervention aiming to encourage the gambler to set deposit limits, practice self-exclusion, or seek help. This protocol paper describes the two-tailed evaluation of this intervention: (1) A retrospective, register-based study of the effectiveness of the motivational intervention on gambling expenditures, deposit limits, and self-exclusions in comparison to control individuals not reached by the intervention, including all clients reached or attempted to be reached during September 2019-April 2020 (total n = 3626), as well as a one-to-one matched comparison of clients reached (n = 1404) and not reached; and (2) a prospective web survey study in individuals reached by the same ongoing telephone intervention practice from November 2020 (target n = 200), measuring clients' attitudes to the intervention, perceived effects of the intervention on gambling, and their self-reported gambling on all operators after the intervention.", "doi": "10.3390/ijerph17239069", "pmid": "33561040", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph17239069"}], "notes": [], "created": "2021-02-10T18:44:43.305Z", "modified": "2021-02-26T08:47:00.274Z"}, {"entity": "publication", "iuid": "1d1d051d522c4e08ae59fe3448e9558a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d1d051d522c4e08ae59fe3448e9558a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d1d051d522c4e08ae59fe3448e9558a"}}, "title": "Harnessing the Power of Social Media to Support a Professional Learning Network During the COVID-19 Pandemic.", "authors": [{"family": "Hall", "given": "Elissa", "initials": "E"}, {"family": "Kreuter", "given": "Justin D", "initials": "JD"}, {"family": "S\u00f6r\u00f6", "given": "Teresa", "initials": "T"}, {"family": "Dzara", "given": "Kristina", "initials": "K"}, {"family": "Gooding", "given": "Holly C", "initials": "HC"}], "type": "journal article", "published": "2020-12-04", "journal": {"title": "J Contin Educ Health Prof", "issn": "1554-558X", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1097/CEH.0000000000000326", "pmid": "33290300", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-10T09:13:53.850Z", "modified": "2020-12-10T09:14:04.250Z"}, {"entity": "publication", "iuid": "9ceaca5cb62245e8a1173dd1758a02d2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ceaca5cb62245e8a1173dd1758a02d2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ceaca5cb62245e8a1173dd1758a02d2"}}, "title": "Choir Singers Without Rehearsals and Concerts? A Questionnaire Study on Perceived Losses From Restricting Choral Singing During the Covid-19 Pandemic.", "authors": [{"family": "Theorell", "given": "T\u00f6res", "initials": "T"}, {"family": "Kowalski", "given": "Jan", "initials": "J"}, {"family": "Theorell", "given": "Ann Mari Lind", "initials": "AML"}, {"family": "Horwitz", "given": "Eva Bojner", "initials": "EB"}], "type": "journal article", "published": "2020-12-04", "journal": {"title": "J Voice", "issn": "1873-4588", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Choir singing is an activity that engages individuals all over the world with a broad demographic representation. Both qualitative and quantitative studies have examined the benefits of the activity but very few have examined the effects when someone loses access to it and stops singing.\r\n\r\nExamining the governmental and organisational responses precipitated by the COVID-19 pandemic, we asked what happens when a choir singer loses all of their routines associated with regular participation in choir singing.\r\n\r\nOne national choir organization in Sweden (n = 3163) and one in Norway (n = 1881) were approached with a short survey. This comprised questions relating to the issue \"what do you as a choir singer misses the most?\" Each participant was asked to rate the importance of a number of elements that pertain to the experience of choir singing.\r\n\r\nThe social aspect of singing emerged as having the strongest weight in terms of perceived loss that is, it was the element that the participants missed the most. Professional singers report that they miss the aesthetic experiences, flow, and all the physical aspects (physical training, voice training, and breathing training) to a greater degree as compared to reports from the amateurs. The importance of aesthetic experiences and physical components appeared to rise with increasing number of years that an individual had engaged with choir singing.\r\n\r\nIn the Scandinavian setting, the social aspect has a stronger weight than the other components and this seemed to be more significant in Norway compared to Sweden.", "doi": "10.1016/j.jvoice.2020.11.006", "pmid": "33288380", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0892-1997(20)30422-7"}], "notes": [], "created": "2020-12-10T09:15:41.012Z", "modified": "2022-11-22T05:49:56.111Z"}, {"entity": "publication", "iuid": "ee547b2d04a741ffa826a9ee92b9593c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee547b2d04a741ffa826a9ee92b9593c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee547b2d04a741ffa826a9ee92b9593c"}}, "title": "A Novel Approach to Hematology Testing at the Point of Care.", "authors": [{"family": "Bransky", "given": "Avishay", "initials": "A"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Aardal", "given": "Elisabeth", "initials": "E"}, {"family": "Ben-Yosef", "given": "Yaara", "initials": "Y"}, {"family": "Christenson", "given": "Robert H", "initials": "RH"}], "type": "journal article", "published": "2020-12-04", "journal": {"title": "J Appl Lab Med", "issn": "2576-9456", "volume": null, "issue": null, "issn-l": null}, "abstract": "The need for rapid point-of-care (POC) diagnostics is now becoming more evident due to the increasing need for timely results and improvement in healthcare service. With the recent COVID-19 pandemic outbreak, POC has become critical in managing the spread of disease. Applicable diagnostics should be readily deployable, easy to use, portable, and accurate so that they fit mobile laboratories, pop-up treatment centers, field hospitals, secluded wards within hospitals, or remote regions, and can be operated by staff with minimal training. Complete blood count (CBC), however, has not been available at the POC in a simple-to-use device until recently. The HemoScreen, which was recently cleared by the FDA for POC use, is a miniature, easy-to-use instrument that uses disposable cartridges and may fill this gap.\n\nThe HemoScreen's analysis method, in contrast to standard laboratory analyzers, is based on machine vision (image-based analysis) and artificial intelligence (AI). We discuss the different methods currently used and compare their results to the vision-based one. The HemoScreen is found to correlate well to laser and impedance-based methods while emphasis is given to mean cell volume (MCV), mean cell hemoglobin (MCH), and platelets (PLT) that demonstrate better correlation when the vision-based method is compared to itself due to the essential differences between the underlying technologies.\n\nThe HemoScreen analyzer demonstrates lab equivalent performance, tested at different clinical settings and sample characteristics, and might outperform standard techniques in the presence of certain interferences. This new approach to hematology testing has great potential to improve quality of care in a variety of settings.", "doi": "10.1093/jalm/jfaa186", "pmid": "33274357", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "6020101"}], "notes": [], "created": "2020-12-06T07:07:57.964Z", "modified": "2021-02-26T08:46:13.585Z"}, {"entity": "publication", "iuid": "ae653e3642a04dc0b8c1b2550cb03a7d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ae653e3642a04dc0b8c1b2550cb03a7d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ae653e3642a04dc0b8c1b2550cb03a7d"}}, "title": "Risk perception and determinants in small- and medium-sized agri-food enterprises amidst the COVID-19 pandemic: Evidence from Egypt.", "authors": [{"family": "Abu Hatab", "given": "Assem", "initials": "A"}, {"family": "Lagerkvist", "given": "Carl-Johan", "initials": "CJ"}, {"family": "Esmat", "given": "Abourehab", "initials": "A"}], "type": "journal article", "published": "2020-12-03", "journal": {"title": "Agribusiness (N Y N Y)", "issn": "1520-6297", "volume": null, "issue": null, "issn-l": null}, "abstract": "The coronavirus disease-2019 (COVID-19) pandemic has disrupted many activities along agri-food supply chains in developing countries and posed unprecedented challenges in particular to small and medium agri-food enterprises (SMEs). Drawing on a survey of 166 Egyptian agri-food SMEs, this study investigates differences in- and determinants of COVID-19 business risk perception among these enterprises. The empirical results showed that risk perception was highly asymmetric across geographical regions. Enterprises with longer cash flow coverage periods and higher values of total assets perceived significantly lower risk levels, as cash and assets functioned as a buffer against the impact of COVID-19. The findings of the study imply that the \"just-in-time\" approach and the absence of a proactive and preventative stance to risk management reduced the resilience of agri-food SMEs to the risks presented by the pandemic. Generally, enterprises that operate both in domestic and export markets perceived lower COVID-19 risks. Finally, the main export destination to which the surveyed enterprises export was a significant determinant of their risk perception. These findings could be useful to managers of agri-food businesses in terms of better understanding of risks and promotion of risk management practices. More so, they can help design effective policy interventions to mitigate the impacts of the pandemic on Egyptian agri-food SMEs and build up their resilience to future pandemics and shocks.", "doi": "10.1002/agr.21676", "pmid": "33362335", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "AGR21676"}, {"db": "pmc", "key": "PMC7753412"}], "notes": [], "created": "2021-01-07T13:40:07.426Z", "modified": "2021-01-10T17:25:27.745Z"}, {"entity": "publication", "iuid": "7a0e1b89eac4430dbb65390fb3a90d76", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a0e1b89eac4430dbb65390fb3a90d76.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a0e1b89eac4430dbb65390fb3a90d76"}}, "title": "Patients With COVID-19 Have Elevated Levels of Circulating Extracellular Vesicle Tissue Factor Activity That Is Associated With Severity and Mortality.", "authors": [{"family": "Rosell", "given": "Axel", "initials": "A"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "von Meijenfeldt", "given": "Fien", "initials": "F"}, {"family": "Hisada", "given": "Yohei", "initials": "Y"}, {"family": "Aguilera", "given": "Katherina", "initials": "K"}, {"family": "Grover", "given": "Steven P", "initials": "SP"}, {"family": "Lisman", "given": "Ton", "initials": "T"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2020-12-03", "journal": {"title": "Arterioscler Thromb Vasc Biol", "issn": "1524-4636", "issn-l": null, "volume": "41", "issue": "2", "pages": "ATVBAHA120315547"}, "abstract": "Patients with coronavirus disease 2019 (COVID-19) have a high rate of thrombosis. We hypothesized that severe acute respiratory syndrome coronavirus 2 leads to induction of TF (tissue factor) expression and increased levels of circulating TF-positive extracellular vesicles (EV) that may drive thrombosis. Approach and Results: We measured levels of plasma EV TF activity in 100 patients with COVID-19 with moderate and severe disease and 28 healthy controls. Levels of EV TF activity were significantly higher in patients with COVID-19 compared with controls. In addition, levels of EV TF activity were associated with disease severity and mortality. Finally, levels of EV TF activity correlated with several plasma markers, including D-dimer, which has been shown to be associated with thrombosis in patients with COVID-19.\r\n\r\nOur results indicate that severe acute respiratory syndrome coronavirus 2 infection induces the release of TF-positive EVs into the circulation that are likely to contribute to thrombosis in patients with COVID-19. EV TF activity was also associated with severity and mortality.", "doi": "10.1161/ATVBAHA.120.315547", "pmid": "33267656", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-09T06:14:18.210Z", "modified": "2021-06-13T06:02:55.694Z"}, {"entity": "publication", "iuid": "76d13794cf40457aae8704e08f7676e0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76d13794cf40457aae8704e08f7676e0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76d13794cf40457aae8704e08f7676e0"}}, "title": "Helmet continuous positive airway pressure versus high-flow nasal cannula in COVID-19: a pragmatic randomised clinical trial (COVID HELMET).", "authors": [{"family": "Tverring", "given": "Jonas", "initials": "J"}, {"family": "\u00c5kesson", "given": "Anna", "initials": "A"}, {"family": "Nielsen", "given": "Niklas", "initials": "N"}], "type": "journal article", "published": "2020-12-03", "journal": {"title": "Trials", "issn": "1745-6215", "volume": "21", "issue": "1", "pages": "994", "issn-l": null}, "abstract": "Patients with COVID-19 and hypoxaemia despite conventional low-flow oxygen therapy are often treated with high-flow nasal cannula (HFNC) in line with international guidelines. Oxygen delivery by helmet continuous positive airway pressure (CPAP) is a feasible option that enables a higher positive end-expiratory pressure (PEEP) and may theoretically reduce the need for intubation compared to HFNC but direct comparative evidence is lacking.\n\nWe plan to perform an investigator-initiated, pragmatic, randomised trial at an intermediate-level COVID-19 cohort ward in Helsingborg Hospital, southern Sweden. We have estimated a required sample size of 120 patients randomised 1:1 to HFNC or Helmet CPAP to achieve 90% power to detect superiority at a 0.05 significance level regarding the primary outcome of ventilator free days (VFD) within 28 days using a Mann-Whitney U test. Patient recruitment is planned to being June 2020 and be completed in the first half of 2021.\n\nWe hypothesise that the use of Helmet CPAP will reduce the need for invasive mechanical ventilation compared to the use of HFNC without having a negative effect on survival. This could have important implications during the current COVID-19 epidemic.\n\nClinicalTrials.gov NCT04395807 . Registered on 20 May 2020.", "doi": "10.1186/s13063-020-04863-5", "pmid": "33272319", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13063-020-04863-5"}, {"db": "ClinicalTrials.gov", "key": "NCT04395807"}], "notes": [], "created": "2020-12-06T07:08:35.572Z", "modified": "2021-02-26T08:46:13.272Z"}, {"entity": "publication", "iuid": "d24497021abf4097b4a19066fdd7cdb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d24497021abf4097b4a19066fdd7cdb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d24497021abf4097b4a19066fdd7cdb1"}}, "title": "Clinical characteristics of SARS-CoV-2 infection in children with cystic fibrosis: An international observational study.", "authors": [{"family": "Bain", "given": "Robert", "initials": "R"}, {"family": "Cosgriff", "given": "Rebecca", "initials": "R"}, {"family": "Zampoli", "given": "Marco", "initials": "M"}, {"family": "Elbert", "given": "Alexander", "initials": "A"}, {"family": "Burgel", "given": "Pierre-R\u00e9gis", "initials": "PR"}, {"family": "Carr", "given": "Siobh\u00e1n B", "initials": "SB"}, {"family": "Casta\u00f1os", "given": "Claudio", "initials": "C"}, {"family": "Colombo", "given": "Carla", "initials": "C"}, {"family": "Corvol", "given": "Harriet", "initials": "H"}, {"family": "Faro", "given": "Albert", "initials": "A"}, {"family": "Goss", "given": "Christopher H", "initials": "CH"}, {"family": "Gutierrez", "given": "Hector", "initials": "H"}, {"family": "Jung", "given": "Andreas", "initials": "A"}, {"family": "Kashirskaya", "given": "Nataliya", "initials": "N"}, {"family": "Marshall", "given": "Bruce C", "initials": "BC"}, {"family": "Melo", "given": "Joel", "initials": "J"}, {"family": "Mondejar-Lopez", "given": "Pedro", "initials": "P"}, {"family": "de Monestrol", "given": "Isabelle", "initials": "I"}, {"family": "Naehrlich", "given": "Lutz", "initials": "L"}, {"family": "Pastor-Vivero", "given": "Maria Dolores", "initials": "MD"}, {"family": "Rizvi", "given": "Samar", "initials": "S"}, {"family": "Filho", "given": "Luiz Vicente Ribeiro Ferreira da Silva", "initials": "LVRFDS"}, {"family": "Brownlee", "given": "Keith G", "initials": "KG"}, {"family": "Haq", "given": "Iram J", "initials": "IJ"}, {"family": "Brodlie", "given": "Malcolm", "initials": "M"}], "type": "journal article", "published": "2020-12-03", "journal": {"title": "J Cyst Fibros", "issn": "1873-5010", "volume": null, "issue": null, "issn-l": null}, "abstract": "The presence of co-morbidities, including underlying respiratory problems, has been identified as a risk factor for severe COVID-19 disease. Information on the clinical course of SARS-CoV-2 infection in children with cystic fibrosis (CF) is limited, yet vital to provide accurate advice for children with CF, their families, caregivers and clinical teams.\n\nCases of SARS-CoV-2 infection in children with CF aged less than 18 years were collated by the CF Registry Global Harmonization Group across 13 countries between 1 February and 7 August 2020.\n\nData on 105 children were collated and analysed. Median age of cases was ten years (interquartile range 6-15), 54% were male and median percentage predicted forced expiratory volume in one second was 94% (interquartile range 79-104). The majority (71%) of children were managed in the community during their COVID-19 illness. Out of 24 children admitted to hospital, six required supplementary oxygen and two non-invasive ventilation. Around half were prescribed antibiotics, five children received antiviral treatments, four azithromycin and one additional corticosteroids. Children that were hospitalised had lower lung function and reduced body mass index Z-scores. One child died six weeks after testing positive for SARS-CoV-2 following a deterioration that was not attributed to COVID-19 disease.\n\nSARS-CoV-2 infection in children with CF is usually associated with a mild illness in those who do not have pre-existing severe lung disease.", "doi": "10.1016/j.jcf.2020.11.021", "pmid": "33309057", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1569-1993(20)30931-0"}, {"db": "pmc", "key": "PMC7713571"}], "notes": [], "created": "2020-12-21T10:19:07.648Z", "modified": "2021-02-26T08:47:00.215Z"}, {"entity": "publication", "iuid": "4e5914a83e6b48158f9a6b16ce45f216", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4e5914a83e6b48158f9a6b16ce45f216.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4e5914a83e6b48158f9a6b16ce45f216"}}, "title": "COVID-19 misinformation: Mere harmless delusions or much more? A knowledge and attitude cross-sectional study among the general public residing in Jordan.", "authors": [{"family": "Sallam", "given": "Malik", "initials": "M"}, {"family": "Dababseh", "given": "Deema", "initials": "D"}, {"family": "Yaseen", "given": "Alaa", "initials": "A"}, {"family": "Al-Haidar", "given": "Ayat", "initials": "A"}, {"family": "Taim", "given": "Duaa", "initials": "D"}, {"family": "Eid", "given": "Huda", "initials": "H"}, {"family": "Ababneh", "given": "Nidaa A", "initials": "NA"}, {"family": "Bakri", "given": "Faris G", "initials": "FG"}, {"family": "Mahafzah", "given": "Azmi", "initials": "A"}], "type": "journal article", "published": "2020-12-03", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "15", "issue": "12", "pages": "e0243264"}, "abstract": "Since the emergence of the recent coronavirus disease 2019 (COVID-19) and its spread as a pandemic, media was teeming with misinformation that led to psychologic, social and economic consequences among the global public. Probing knowledge and anxiety regarding this novel infectious disease is necessary to identify gaps in knowledge and sources of misinformation which can help public health efforts to design and implement more focused interventional measures. The aim of this study was to evaluate the knowledge, attitude and effects of misinformation about COVID-19 on anxiety level among the general public residing in Jordan. This cross-sectional study was conducted using an online-based questionnaire that took place in April 2020, which targeted people residing in Jordan, aged 18 and above. The questionnaire included items on the following: demographic characteristics of the participants, knowledge about COVID-19, anxiety level and misconceptions regarding the origin of the pandemic. The total number of participants included in final analysis was 3150. The study population was predominantly females (76.0%), with mean age of 31 years. The overall knowledge of COVID-19 was satisfactory. Older age, males, lower monthly income and educational levels, smoking and history of chronic disease were associated with perceiving COVID-19 as a very dangerous disease. Variables that were associated with a higher anxiety level during the pandemic included: lower monthly income and educational level, residence outside the capital (Amman) and history of smoking. Misinformation about the origin of the pandemic (being part of a conspiracy, biologic warfare and the 5G networks role) was also associated with higher anxiety levels. Social media platforms, TV and news releases were the most common sources of information about the pandemic. The study showed the potential harmful effects of misinformation on the general public and emphasized the need to meticulously deliver timely and accurate information about the pandemic to lessen the health, social and psychological impact of the disease.", "doi": "10.1371/journal.pone.0243264", "pmid": "33270783", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-21682"}], "notes": [], "created": "2020-12-06T07:09:15.849Z", "modified": "2022-11-23T09:03:19.499Z"}, {"entity": "publication", "iuid": "18eed320c23f4102b00dbb87e7e9029b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18eed320c23f4102b00dbb87e7e9029b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18eed320c23f4102b00dbb87e7e9029b"}}, "title": "The Structural Basis of Accelerated Host Cell Entry by SARS-CoV-2 \u2020.", "authors": [{"family": "Seyran", "given": "Murat", "initials": "M"}, {"family": "Takayama", "given": "Kazuo", "initials": "K"}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN"}, {"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Pal\u00f9", "given": "Giorgio", "initials": "G"}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Attrish", "given": "Diksha", "initials": "D"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA"}, {"family": "Ghosh", "given": "Shinjini", "initials": "S"}, {"family": "Pizzol", "given": "Damiano", "initials": "D"}, {"family": "Chauhan", "given": "Gaurav", "initials": "G"}, {"family": "Adadi", "given": "Parise", "initials": "P"}, {"family": "Mohamed Abd El-Aziz", "given": "Tarek", "initials": "T"}, {"family": "Soares", "given": "Antonio G", "initials": "AG"}, {"family": "Kandimalla", "given": "Ramesh", "initials": "R"}, {"family": "Tambuwala", "given": "Murtaza", "initials": "M"}, {"family": "Sarif Hassan", "given": "Sk", "initials": "S"}, {"family": "Kumar Azad", "given": "Gajendra", "initials": "G"}, {"family": "Pal Choudhury", "given": "Pabitra", "initials": "P"}, {"family": "Baetas-da-Cruz", "given": "Wagner", "initials": "W"}, {"family": "Serrano-Aroca", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "Brufsky", "given": "Adam M", "initials": "AM"}, {"family": "Uhal", "given": "Bruce D", "initials": "BD"}], "type": "journal article", "published": "2020-12-02", "journal": {"title": "FEBS J", "issn": "1742-4658", "volume": null, "issue": null, "issn-l": null}, "abstract": "Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of the pandemic coronavirus disease 2019 (COVID-19) that exhibits an overwhelming contagious capacity over other Human Coronaviruses (HCoVs). This structural snapshot describes the structural bases underlying the pandemic capacity of SARS-CoV-2 and explains its fast motion over respiratory epithelia that allow its rapid cellular entry. Based on notable viral spike (S) protein features, we propose that the flat sialic acid-binding domain at the N-terminal domain (NTD) of the S1 subunit leads to more effective first contact and interaction with the sialic acid layer over the epithelium and this, in turn, allows faster viral \"surfing\" of the epithelium and receptor scanning by SARS-CoV-2. Angiotensin-converting enzyme 2 (ACE-2) protein on the epithelial surface is the primary entry receptor for SARS-CoV-2, and protein-protein interaction assays demonstrate high-affinity binding of the S protein to ACE-2. To date, no high-frequency mutations were detected at the C-terminal domain (CTD) of the S1 subunit in the S protein, where the receptor-binding domain (RBD) is located. Tight binding to ACE-2 by a conserved viral RBD suggests the ACE2-RBD interaction is likely optimal. Moreover, the viral S subunit contains a cleavage site for furin and other proteases, which accelerates cell entry by SARS-CoV-2. The model proposed here describes a structural basis for the accelerated host cell entry by SARS-CoV-2 relative to other HCoVs, and also discusses emerging hypotheses that are likely to contribute to the development of antiviral strategies to combat the pandemic capacity of SARS-CoV-2.", "doi": "10.1111/febs.15651", "pmid": "33264497", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Proteins": null}, "xrefs": [], "notes": [], "created": "2020-12-03T08:14:27.869Z", "modified": "2021-02-26T08:47:18.753Z"}, {"entity": "publication", "iuid": "65b0f9f550b94462a14f0e75bbd3e9ed", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65b0f9f550b94462a14f0e75bbd3e9ed.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65b0f9f550b94462a14f0e75bbd3e9ed"}}, "title": "Lack of evidence of ACE2 expression and replicative infection by SARS-CoV-2 in human endothelial cells", "authors": [{"family": "McCracken", "given": "Ian", "initials": "I"}, {"family": "Saginc", "given": "Gaye", "initials": "G"}, {"family": "He", "given": "Liqun", "initials": "L"}, {"family": "Huseynov", "given": "Alik", "initials": "A"}, {"family": "Daniels", "given": "Alison", "initials": "A"}, {"family": "Fletcher", "given": "Sarah", "initials": "S"}, {"family": "Peghaire", "given": "Claire", "initials": "C"}, {"family": "Kalna", "given": "Viktoria", "initials": "V"}, {"family": "Andaloussi-M\u00e4e", "given": "Maarja", "initials": "M"}, {"family": "Muhl", "given": "Lars", "initials": "L"}, {"family": "Craig", "given": "Nicky M", "initials": "NM"}, {"family": "Griffiths", "given": "Samantha J", "initials": "SJ"}, {"family": "Haas", "given": "J\u00fcrgen G", "initials": "JG"}, {"family": "Tait-Burkard", "given": "Christine", "initials": "C"}, {"family": "Lendahl", "given": "Urban", "initials": "U"}, {"family": "Birdsey", "given": "Graeme M", "initials": "GM"}, {"family": "Betsholtz", "given": "Christer", "initials": "C"}, {"family": "Noseda", "given": "Michela", "initials": "M"}, {"family": "Baker", "given": "Andrew", "initials": "A"}, {"family": "Randi", "given": "Anna M", "initials": "AM"}], "type": "posted-content", "published": "2020-12-02", "journal": {"title": "", "issn": null, "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1101/2020.12.02.391664", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-06-10T04:18:46.697Z", "modified": "2021-06-10T04:19:16.922Z"}, {"entity": "publication", "iuid": "68f8998fb8eb43d1b66b8b9accbeedbb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68f8998fb8eb43d1b66b8b9accbeedbb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68f8998fb8eb43d1b66b8b9accbeedbb"}}, "title": "Dietary supplements during the COVID-19 pandemic: insights from 1.4M users of the COVID Symptom Study app - a longitudinal app-based community survey", "authors": [{"family": "Louca", "given": "Panayiotis", "initials": "P"}, {"family": "Murray", "given": "Benjamin", "initials": "B"}, {"family": "Klaser", "given": "K", "initials": "K"}, {"family": "Graham", "given": "MS", "initials": "M"}, {"family": "Mazidi", "given": "M", "initials": "M"}, {"family": "Leeming", "given": "ER", "initials": "E"}, {"family": "Thompson", "given": "E", "initials": "E"}, {"family": "Bowyer", "given": "R", "initials": "R"}, {"family": "Drew", "given": "DA", "initials": "D"}, {"family": "Nguyen", "given": "LH", "initials": "L"}, {"family": "Merino", "given": "J", "initials": "J"}, {"family": "Gomez", "given": "M", "initials": "M"}, {"family": "Mompeo", "given": "O", "initials": "O"}, {"family": "Costeira", "given": "R", "initials": "R"}, {"family": "Sudre", "given": "CH", "initials": "C"}, {"family": "Gibson", "given": "R", "initials": "R"}, {"family": "Steves", "given": "CJ", "initials": "C"}, {"family": "Wolf", "given": "J V", "initials": "JV"}, {"family": "Franks", "given": "PW", "initials": "P"}, {"family": "Ourselin", "given": "S", "initials": "S"}, {"family": "Chan", "given": "AT", "initials": "A"}, {"family": "Berry", "given": "SE", "initials": "S"}, {"family": "Valdes", "given": "AM", "initials": "A"}, {"family": "Calder", "given": "PC", "initials": "P"}, {"family": "Spector", "given": "TD", "initials": "T"}, {"family": "Menni", "given": "C", "initials": "C"}], "type": "posted-content", "published": "2020-12-02", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.11.27.20239087", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-02T07:31:41.833Z", "modified": "2021-03-10T15:20:35.782Z"}, {"entity": "publication", "iuid": "d10da61364bd4d2ba71ac7c1e0001a18", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d10da61364bd4d2ba71ac7c1e0001a18.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d10da61364bd4d2ba71ac7c1e0001a18"}}, "title": "Correction to: Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS.", "authors": [{"family": "Ferrando", "given": "Carlos", "initials": "C"}, {"family": "Suarez-Sipmann", "given": "Fernando", "initials": "F"}, {"family": "Mellado-Artigas", "given": "Ricard", "initials": "R"}, {"family": "Hern\u00e1ndez", "given": "Mar\u00eda", "initials": "M"}, {"family": "Gea", "given": "Alfredo", "initials": "A"}, {"family": "Arruti", "given": "Egoitz", "initials": "E"}, {"family": "Aldecoa", "given": "C\u00e9sar", "initials": "C"}, {"family": "Mart\u00ednez-Pall\u00ed", "given": "Graciela", "initials": "G"}, {"family": "Mart\u00ednez-Gonz\u00e1lez", "given": "Miguel A", "initials": "MA"}, {"family": "Slutsky", "given": "Arthur S", "initials": "AS"}, {"family": "Villar", "given": "Jes\u00fas", "initials": "J"}, {"family": "COVID-19 Spanish ICU Network", "given": "", "initials": ""}], "type": "published erratum", "published": "2020-12-02", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "volume": null, "issue": null, "issn-l": "0342-4642"}, "abstract": "The original version of this article unfortunately contained mistakes in Figures 1 and 3.", "doi": "10.1007/s00134-020-06251-8", "pmid": "33263817", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-020-06251-8"}], "notes": [], "created": "2020-12-03T08:15:09.651Z", "modified": "2020-12-03T15:45:39.142Z"}, {"entity": "publication", "iuid": "c82b76966c9f480594729958632f9b2b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c82b76966c9f480594729958632f9b2b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c82b76966c9f480594729958632f9b2b"}}, "title": "Clinical and molecular practice of European thoracic pathology laboratories during the COVID-19 pandemic. The past and the near future.", "authors": [{"family": "Hofman", "given": "P", "initials": "P"}, {"family": "Ili\u00e9", "given": "M", "initials": "M"}, {"family": "Chamorey", "given": "E", "initials": "E"}, {"family": "Brest", "given": "P", "initials": "P"}, {"family": "Schiappa", "given": "R", "initials": "R"}, {"family": "Nakache", "given": "V", "initials": "V"}, {"family": "Antoine", "given": "M", "initials": "M"}, {"family": "Barberis", "given": "M", "initials": "M"}, {"family": "Begueret", "given": "H", "initials": "H"}, {"family": "Bibeau", "given": "F", "initials": "F"}, {"family": "Bonnetaud", "given": "C", "initials": "C"}, {"family": "Bostr\u00f6m", "given": "P", "initials": "P"}, {"family": "Brousset", "given": "P", "initials": "P"}, {"family": "Bubendorf", "given": "L", "initials": "L"}, {"family": "Carvalho", "given": "L", "initials": "L"}, {"family": "Cathomas", "given": "G", "initials": "G"}, {"family": "Cazes", "given": "A", "initials": "A"}, {"family": "Chalabreysse", "given": "L", "initials": "L"}, {"family": "Chenard", "given": "M-P", "initials": "MP"}, {"family": "Copin", "given": "M-C", "initials": "MC"}, {"family": "C\u00f4t\u00e9", "given": "J-F", "initials": "JF"}, {"family": "Damotte", "given": "D", "initials": "D"}, {"family": "de Leval", "given": "L", "initials": "L"}, {"family": "Delongova", "given": "P", "initials": "P"}, {"family": "Thomas de Montpreville", "given": "V", "initials": "V"}, {"family": "de Muret", "given": "A", "initials": "A"}, {"family": "Dema", "given": "A", "initials": "A"}, {"family": "Dietmaier", "given": "W", "initials": "W"}, {"family": "Evert", "given": "M", "initials": "M"}, {"family": "Fabre", "given": "A", "initials": "A"}, {"family": "Forest", "given": "F", "initials": "F"}, {"family": "Foulet", "given": "A", "initials": "A"}, {"family": "Garcia", "given": "S", "initials": "S"}, {"family": "Garcia-Martos", "given": "M", "initials": "M"}, {"family": "Gibault", "given": "L", "initials": "L"}, {"family": "Gorkiewicz", "given": "G", "initials": "G"}, {"family": "Jonigk", "given": "D", "initials": "D"}, {"family": "Gosney", "given": "J", "initials": "J"}, {"family": "Hofman", "given": "A", "initials": "A"}, {"family": "Kern", "given": "I", "initials": "I"}, {"family": "Kerr", "given": "K", "initials": "K"}, {"family": "Kossai", "given": "M", "initials": "M"}, {"family": "Kriegsmann", "given": "M", "initials": "M"}, {"family": "Lassalle", "given": "S", "initials": "S"}, {"family": "Long-Mira", "given": "E", "initials": "E"}, {"family": "Lupo", "given": "A", "initials": "A"}, {"family": "Mamilos", "given": "A", "initials": "A"}, {"family": "Mat\u011bj", "given": "R", "initials": "R"}, {"family": "Meilleroux", "given": "J", "initials": "J"}, {"family": "Ortiz-Villal\u00f3n", "given": "C", "initials": "C"}, {"family": "Panico", "given": "L", "initials": "L"}, {"family": "Panizo", "given": "A", "initials": "A"}, {"family": "Papotti", "given": "M", "initials": "M"}, {"family": "Pauwels", "given": "P", "initials": "P"}, {"family": "Pelosi", "given": "G", "initials": "G"}, {"family": "Penault-Llorca", "given": "F", "initials": "F"}, {"family": "Pop", "given": "O", "initials": "O"}, {"family": "Pot\u00e9", "given": "N", "initials": "N"}, {"family": "Cajal", "given": "S R Y", "initials": "SRY"}, {"family": "Sabourin", "given": "J-C", "initials": "JC"}, {"family": "Salmon", "given": "I", "initials": "I"}, {"family": "Sajin", "given": "M", "initials": "M"}, {"family": "Savic-Prince", "given": "S", "initials": "S"}, {"family": "Schildhaus", "given": "H-U", "initials": "HU"}, {"family": "Schirmacher", "given": "P", "initials": "P"}, {"family": "Serre", "given": "I", "initials": "I"}, {"family": "Shaw", "given": "E", "initials": "E"}, {"family": "Sizaret", "given": "D", "initials": "D"}, {"family": "Stenzinger", "given": "A", "initials": "A"}, {"family": "Stojsic", "given": "J", "initials": "J"}, {"family": "Thunnissen", "given": "E", "initials": "E"}, {"family": "Timens", "given": "W", "initials": "W"}, {"family": "Troncone", "given": "G", "initials": "G"}, {"family": "Werlein", "given": "C", "initials": "C"}, {"family": "Wolff", "given": "H", "initials": "H"}, {"family": "Berthet", "given": "J-P", "initials": "JP"}, {"family": "Benzaquen", "given": "J", "initials": "J"}, {"family": "Marquette", "given": "C-H", "initials": "CH"}, {"family": "Hofman", "given": "V", "initials": "V"}, {"family": "Calabrese", "given": "F", "initials": "F"}], "type": "journal article", "published": "2020-12-02", "journal": {"title": "ESMO Open", "issn": "2059-7029", "volume": "6", "issue": "1", "pages": "100024", "issn-l": null}, "abstract": "This study evaluated the consequences in Europe of the COVID-19 outbreak on pathology laboratories orientated toward the diagnosis of thoracic diseases.\n\nA survey was sent to 71 pathology laboratories from 21 European countries. The questionnaire requested information concerning the organization of biosafety, the clinical and molecular pathology, the biobanking, the workload, the associated research into COVID-19, and the organization of education and training during the COVID-19 crisis, from 15 March to 31 May 2020, compared with the same period in 2019.\n\nQuestionnaires were returned from 53/71 (75%) laboratories from 18 European countries. The biosafety procedures were heterogeneous. The workload in clinical and molecular pathology decreased dramatically by 31% (range, 3%-55%) and 26% (range, 7%-62%), respectively. According to the professional category, between 28% and 41% of the staff members were not present in the laboratories but did teleworking. A total of 70% of the laboratories developed virtual meetings for the training of residents and junior pathologists. During the period of study, none of the staff members with confirmed COVID-19 became infected as a result of handling samples.\n\nThe COVID-19 pandemic has had a strong impact on most of the European pathology laboratories included in this study. Urgent implementation of several changes to the organization of most of these laboratories, notably to better harmonize biosafety procedures, was noted at the onset of the pandemic and maintained in the event of a new wave of infection occurring in Europe.", "doi": "10.1016/j.esmoop.2020.100024", "pmid": "33399086", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-07T09:59:21.979Z", "modified": "2021-02-26T08:45:48.695Z"}, {"entity": "publication", "iuid": "baaedfcf6bed471ba1aff4e643a673f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/baaedfcf6bed471ba1aff4e643a673f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/baaedfcf6bed471ba1aff4e643a673f0"}}, "title": "The association of mode of location activity and mobility with acute coronary syndrome: nationwide ecological study.", "authors": [{"family": "Mohammad", "given": "Moman A", "initials": "MA"}, {"family": "Koul", "given": "Sasha", "initials": "S"}, {"family": "Gale", "given": "Chris P", "initials": "CP"}, {"family": "Alfredsson", "given": "Joakim", "initials": "J"}, {"family": "James", "given": "Stefan", "initials": "S"}, {"family": "Fr\u00f6bert", "given": "Ole", "initials": "O"}, {"family": "Omerovic", "given": "Elmir", "initials": "E"}, {"family": "Erlinge", "given": "David", "initials": "D"}], "type": "journal article", "published": "2020-12-01", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "We aimed to study the effect of social containment mandates on ACS presentation during COVID-19 pandemic using location activity and mobility data from mobile phone map services.\r\n\r\nWe conducted a cross-sectional study using data from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) including all ACS presentations during the pandemic until May 07, 2020. Using a count regression model, we adjusted for day of the week, daily weather, and incidence of COVID-19.\r\n\r\nA 10% increase in activity around areas of residence was associated with 38% lower rates of ACS hospitalisations whereas increased activity relating to retail and recreation, grocery stores and pharmacies, workplaces as well as mode of mobility was associated with 10-20% higher rates of ACS hospitalisations.\r\n\r\nGovernment policy regarding social containment mandates has important public health implications for medical emergencies like ACS and may explain the decline in ACS presentations observed during COVID-19 pandemic.", "doi": "10.1111/joim.13206", "pmid": "33259680", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-12-03T08:16:01.869Z", "modified": "2021-02-26T08:47:00.178Z"}, {"entity": "publication", "iuid": "3e2f34a3e6064d69af05e77761d57bc9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3e2f34a3e6064d69af05e77761d57bc9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3e2f34a3e6064d69af05e77761d57bc9"}}, "title": "Nowcasting the COVID-19 pandemic in Bavaria.", "authors": [{"family": "G\u00fcnther", "given": "Felix", "initials": "F"}, {"family": "Bender", "given": "Andreas", "initials": "A"}, {"family": "Katz", "given": "Katharina", "initials": "K"}, {"family": "K\u00fcchenhoff", "given": "Helmut", "initials": "H"}, {"family": "H\u00f6hle", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2020-12-01", "journal": {"title": "Biom J", "issn": "1521-4036", "volume": null, "issue": null, "issn-l": null}, "abstract": "To assess the current dynamics of an epidemic, it is central to collect information on the daily number of newly diseased cases. This is especially important in real-time surveillance, where the aim is to gain situational awareness, for example, if cases are currently increasing or decreasing. Reporting delays between disease onset and case reporting hamper our ability to understand the dynamics of an epidemic close to now when looking at the number of daily reported cases only. Nowcasting can be used to adjust daily case counts for occurred-but-not-yet-reported events. Here, we present a novel application of nowcasting to data on the current COVID-19 pandemic in Bavaria. It is based on a hierarchical Bayesian model that considers changes in the reporting delay distribution over time and associated with the weekday of reporting. Furthermore, we present a way to estimate the effective time-varying case reproduction number based on predictions of the nowcast. The approaches are based on previously published work, that we considerably extended and adapted to the current task of nowcasting COVID-19 cases. We provide methodological details of the developed approach, illustrate results based on data of the current pandemic, and evaluate the model based on synthetic and retrospective data on COVID-19 in Bavaria. Results of our nowcasting are reported to the Bavarian health authority and published on a webpage on a daily basis (https://corona.stat.uni-muenchen.de/). Code and synthetic data for the analysis are available from https://github.com/FelixGuenther/nc_covid19_bavaria and can be used for adaption of our approach to different data. R e ( t )", "doi": "10.1002/bimj.202000112", "pmid": "33258177", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-03T08:17:03.493Z", "modified": "2021-02-26T08:46:13.061Z"}, {"entity": "publication", "iuid": "4c2735cd7177484b885331b93bacba85", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4c2735cd7177484b885331b93bacba85.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4c2735cd7177484b885331b93bacba85"}}, "title": "Modeling of the adsorption of a protein-fragment on kaolinite with potential antiviral activity.", "authors": [{"family": "Awad", "given": "Mahmoud E", "initials": "ME"}, {"family": "Borrego-S\u00e1nchez", "given": "Ana", "initials": "A"}, {"family": "Escamilla-Roa", "given": "Elizabeth", "initials": "E"}, {"family": "Hern\u00e1ndez-Laguna", "given": "Alfonso", "initials": "A"}, {"family": "Sainz-D\u00edaz", "given": "C Ignacio", "initials": "CI"}], "type": "journal article", "published": "2020-12-01", "journal": {"title": "Appl Clay Sci", "issn": "0169-1317", "issn-l": null, "volume": "199", "issue": null, "pages": "105865"}, "abstract": "This work aimed at studying the potentiality of interactions between kaolinite surfaces and a protein-fragment (350-370 amino acid units) extracted from the glycoprotein E1 in the transmembrane domain (TMD) of hepatitis C virus capsid. A computational work was performed for locating the potential electrostatic interaction sites between kaolinite aluminol and siloxane surfaces and the residues of this protein-fragment ligand, monitoring the possible conformational changes. This hydrated neutralized kaolinite/protein-fragment system was simulated by means of molecular modeling based on atomistic force fields based on empirical interatomic potentials and molecular dynamic (MD) simulations. The MD calculations indicated that the studied protein-fragment interacted with the kaolinite surfaces with an exothermic process and structural distortions were observed, particularly with the hydrophilic aluminol surface by favorable adsorption energy. The viral units isolation or trapping by the adsorption on the kaolinite nanoparticles producing structural distortion of the peptide ligands could lead to the blockage of the entry on the receptor and hence a lack of viral activity would be produced. Therefore, these findings with the proposed insights could be an useful information for the next experimental and development studies in the area of discovering inhibitors of the global challenged hepatitis and other pathogenic viruses based on the phyllosilicate surface activity. These MD studies can be extended to other viruses like the COVID-19 interacting with silicate minerals surfaces.", "doi": "10.1016/j.clay.2020.105865", "pmid": "33078035", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S0169-1317(20)30430-0"}, {"db": "pmc", "key": "PMC7556793"}], "notes": [], "created": "2020-12-01T16:57:41.658Z", "modified": "2021-02-26T08:45:25.864Z"}, {"entity": "publication", "iuid": "447cc7afc9f745eba4a64bd311f4a71e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/447cc7afc9f745eba4a64bd311f4a71e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/447cc7afc9f745eba4a64bd311f4a71e"}}, "title": "Impact of SARS-CoV-2 Pandemic on Patients with Primary Immunodeficiency.", "authors": [{"family": "Delavari", "given": "Samaneh", "initials": "S"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Abolnezhadian", "given": "Farhad", "initials": "F"}, {"family": "Babaha", "given": "Fateme", "initials": "F"}, {"family": "Iranparast", "given": "Sara", "initials": "S"}, {"family": "Ahanchian", "given": "Hamid", "initials": "H"}, {"family": "Moazzen", "given": "Nasrin", "initials": "N"}, {"family": "Nabavi", "given": "Mohammad", "initials": "M"}, {"family": "Arshi", "given": "Saba", "initials": "S"}, {"family": "Fallahpour", "given": "Morteza", "initials": "M"}, {"family": "Bemanian", "given": "Mohammad Hassan", "initials": "MH"}, {"family": "Shokri", "given": "Sima", "initials": "S"}, {"family": "Momen", "given": "Tooba", "initials": "T"}, {"family": "Sadeghi-Shabestari", "given": "Mahnaz", "initials": "M"}, {"family": "Molatefi", "given": "Rasol", "initials": "R"}, {"family": "Shirkani", "given": "Afshin", "initials": "A"}, {"family": "Vosughimotlagh", "given": "Ahmad", "initials": "A"}, {"family": "Safarirad", "given": "Molood", "initials": "M"}, {"family": "Sharifzadeh", "given": "Meisam", "initials": "M"}, {"family": "Pashangzadeh", "given": "Salar", "initials": "S"}, {"family": "Salami", "given": "Fereshte", "initials": "F"}, {"family": "Shirmast", "given": "Paniz", "initials": "P"}, {"family": "Rezaei", "given": "Arezou", "initials": "A"}, {"family": "Moeini Shad", "given": "Tannaz", "initials": "T"}, {"family": "Mohraz", "given": "Minoo", "initials": "M"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Yazdani", "given": "Reza", "initials": "R"}, {"family": "Aghamohamamdi", "given": "Asghar", "initials": "A"}], "type": "journal article", "published": "2020-12-01", "journal": {"title": "J Clin Immunol", "issn": "1573-2592", "issn-l": "0271-9142", "volume": null, "issue": null, "pages": null}, "abstract": "Although it is estimated that COVID-19 life-threatening conditions may be diagnosed in less than 1:1000 infected individuals below the age of 50, but the real impact of this pandemic on pediatric patients with different types of primary immunodeficiency (PID) is not elucidated. The current prospective study on a national registry of PID patients showed that with only 1.23 folds higher incidence of infections, these patients present a 10-folds higher mortality rate compared to population mainly in patients with combined immunodeficiency and immune dysregulation. Therefore, further management modalities against COVID-19 should be considered to improve the survival rate in these two PID entities using hematopoietic stem cell transplantation and immunomodulatory agents.", "doi": "10.1007/s10875-020-00928-x", "pmid": "33263173", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10875-020-00928-x"}, {"db": "URL", "key": "https://static-content.springer.com/esm/art%3A10.1007%2Fs10875-020-00928-x/MediaObjects/10875_2020_928_MOESM1_ESM.docx", "description": "General laboratory tests, immunologic investigation, computed tomographies of the chest of 17 primary immunodeficient patients infected with COVID-19"}], "notes": [], "created": "2020-12-03T15:43:43.540Z", "modified": "2021-02-26T08:46:59.930Z"}, {"entity": "publication", "iuid": "7c56f4ea33f149498351b25ed3576255", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7c56f4ea33f149498351b25ed3576255.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7c56f4ea33f149498351b25ed3576255"}}, "title": "Guidelines for accurate genotyping of SARS-CoV-2 using amplicon-based sequencing of clinical samples", "authors": [{"family": "Kubik", "given": "Slawomir", "initials": "S"}, {"family": "Marques", "given": "Ana Claudia", "initials": "AC"}, {"family": "Xing", "given": "Xiaobin", "initials": "X"}, {"family": "Silvery", "given": "Janine", "initials": "J"}, {"family": "Bertelli", "given": "Claire", "initials": "C"}, {"family": "De Maio", "given": "Flavio", "initials": "F"}, {"family": "Pournaras", "given": "Spyros", "initials": "S"}, {"family": "Burr", "given": "Tom", "initials": "T"}, {"family": "Duffourd", "given": "Yannis", "initials": "Y"}, {"family": "Siemens", "given": "Helena", "initials": "H"}, {"family": "Alloui", "given": "Chakib", "initials": "C"}, {"family": "Song", "given": "Lin", "initials": "L"}, {"family": "Wenger", "given": "Yvan", "initials": "Y"}, {"family": "Saitta", "given": "Alexandra", "initials": "A"}, {"family": "Macheret", "given": "Morgane", "initials": "M"}, {"family": "Smith", "given": "Ewan W", "initials": "EW"}, {"family": "Menu", "given": "Philippe", "initials": "P"}, {"family": "Brayer", "given": "Marion", "initials": "M"}, {"family": "Steinmetz", "given": "Lars M", "initials": "LM"}, {"family": "Si-Mohammed", "given": "Ali", "initials": "A"}, {"family": "Chuisseu", "given": "Josiane", "initials": "J"}, {"family": "Stevens", "given": "Richard", "initials": "R"}, {"family": "Constantoulakis", "given": "Pantelis", "initials": "P"}, {"family": "Sali", "given": "Michela", "initials": "M"}, {"family": "Greub", "given": "Gilbert", "initials": "G"}, {"family": "Tiemann", "given": "Carsten", "initials": "C"}, {"family": "Pelechano", "given": "Vicent", "initials": "V"}, {"family": "Willig", "given": "Adrian", "initials": "A"}, {"family": "Xu", "given": "Zhenyu", "initials": "Z"}], "type": "posted-content", "published": "2020-12-01", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.01.405738", "pmid": null, "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-20T06:32:09.512Z", "modified": "2021-02-26T08:46:13.311Z"}, {"entity": "publication", "iuid": "477c635341c54c83bea977ad9798e940", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/477c635341c54c83bea977ad9798e940.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/477c635341c54c83bea977ad9798e940"}}, "title": "Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science.", "authors": [{"family": "Evans", "given": "Paul C", "initials": "PC"}, {"family": "Rainger", "given": "G Ed", "initials": "GE"}, {"family": "Mason", "given": "Justin C", "initials": "JC"}, {"family": "Guzik", "given": "Tomasz J", "initials": "TJ"}, {"family": "Osto", "given": "Elena", "initials": "E"}, {"family": "Stamataki", "given": "Zania", "initials": "Z"}, {"family": "Neil", "given": "Desley", "initials": "D"}, {"family": "Hoefer", "given": "Imo E", "initials": "IE"}, {"family": "Fragiadaki", "given": "Maria", "initials": "M"}, {"family": "Waltenberger", "given": "Johannes", "initials": "J"}, {"family": "Weber", "given": "Christian", "initials": "C"}, {"family": "Bochaton-Piallat", "given": "Marie-Luce", "initials": "ML"}, {"family": "B\u00e4ck", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2020-12-01", "journal": {"title": "Cardiovasc Res", "issn": "1755-3245", "volume": "116", "issue": "14", "pages": "2177-2184", "issn-l": null}, "abstract": "The COVID-19 pandemic is an unprecedented healthcare emergency causing mortality and illness across the world. Although primarily affecting the lungs, the SARS-CoV-2 virus also affects the cardiovascular system. In addition to cardiac effects, e.g. myocarditis, arrhythmias, and myocardial damage, the vasculature is affected in COVID-19, both directly by the SARS-CoV-2 virus, and indirectly as a result of a systemic inflammatory cytokine storm. This includes the role of the vascular endothelium in the recruitment of inflammatory leucocytes where they contribute to tissue damage and cytokine release, which are key drivers of acute respiratory distress syndrome (ARDS), in disseminated intravascular coagulation, and cardiovascular complications in COVID-19. There is also evidence linking endothelial cells (ECs) to SARS-CoV-2 infection including: (i) the expression and function of its receptor angiotensin-converting enzyme 2 (ACE2) in the vasculature; (ii) the prevalence of a Kawasaki disease-like syndrome (vasculitis) in COVID-19; and (iii) evidence of EC infection with SARS-CoV-2 in patients with fatal COVID-19. Here, the Working Group on Atherosclerosis and Vascular Biology together with the Council of Basic Cardiovascular Science of the European Society of Cardiology provide a Position Statement on the importance of the endothelium in the underlying pathophysiology behind the clinical presentation in COVID-19 and identify key questions for future research to address. We propose that endothelial biomarkers and tests of function (e.g. flow-mediated dilatation) should be evaluated for their usefulness in the risk stratification of COVID-19 patients. A better understanding of the effects of SARS-CoV-2 on endothelial biology in both the micro- and macrovasculature is required, and endothelial function testing should be considered in the follow-up of convalescent COVID-19 patients for early detection of long-term cardiovascular complications.", "doi": "10.1093/cvr/cvaa230", "pmid": "32750108", "labels": {"Type: Review": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7454368"}, {"db": "pii", "key": "5880580"}], "notes": [], "created": "2020-12-07T15:56:02.856Z", "modified": "2023-07-13T11:29:37.533Z"}, {"entity": "publication", "iuid": "a087f8d635b14ca6b9b1369168d27799", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a087f8d635b14ca6b9b1369168d27799.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a087f8d635b14ca6b9b1369168d27799"}}, "title": "Direct oral anticoagulant use and risk of severe COVID-19.", "authors": [{"family": "Flam", "given": "Benjamin", "initials": "B"}, {"family": "Wintzell", "given": "Viktor", "initials": "V"}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}, {"family": "Pasternak", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2020-12-01", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Hypercoagulability and thromboembolism are prominent features of severe COVID-19, and ongoing anticoagulant use might be protective.\r\n\r\nWe conducted a nationwide register-based cohort study in Sweden, February through May, 2020, to assess whether ongoing direct oral anticoagulant (DOAC) use was associated with reduced risk of hospital admission for laboratory-confirmed COVID-19, or a composite of intensive care unit (ICU) admission or death due to laboratory-confirmed COVID-19.\r\n\r\nDOAC use (n=103 703) was not associated with reduced risk of hospital admission for COVID-19 (adjusted hazard ratio [aHR] [95% confidence interval] 1.00 [0.75-1.33] vs. non-use atrial fibrillation comparator [n=36 875]; and aHR 0.94 [0.80-1.10] vs. non-use cardiovascular disease comparator [n=355 699]), or ICU admission or death due to COVID-19 (aHRs 0.76 [0.51-1.12], and 0.90 [0.71-1.15], respectively).\r\n\r\nOngoing DOAC use was not associated with reduced risk of severe COVID-19, indicating that prognosis would not be modified by early outpatient DOAC initiation.", "doi": "10.1111/joim.13205", "pmid": "33258156", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-03T08:17:34.751Z", "modified": "2021-02-26T08:45:48.532Z"}, {"entity": "publication", "iuid": "00ef148f8d674870a00321fd8e20f2a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/00ef148f8d674870a00321fd8e20f2a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/00ef148f8d674870a00321fd8e20f2a4"}}, "title": "Who safeguards pregnant women's autonomy during the COVID-19 pandemic?", "authors": [{"family": "Linden", "given": "Karolina", "initials": "K"}, {"family": "Maimburg", "given": "Rikke Damkj\u00e6r", "initials": "RD"}], "type": "editorial", "published": "2020-12-00", "journal": {"title": "Sex Reprod Healthc", "issn": "1877-5764", "volume": "26", "issue": null, "pages": "100556", "issn-l": null}, "abstract": null, "doi": "10.1016/j.srhc.2020.100556", "pmid": "33010666", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1877-5756(20)30194-4"}, {"db": "pmc", "key": "PMC7513889"}], "notes": [], "created": "2020-12-03T08:53:50.819Z", "modified": "2020-12-03T08:53:50.842Z"}, {"entity": "publication", "iuid": "261224bff6264269933daf9333f0b375", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/261224bff6264269933daf9333f0b375.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/261224bff6264269933daf9333f0b375"}}, "title": "Transitioning from face-to-face treatment to iCBT for youths in primary care - therapists' attitudes and experiences.", "authors": [{"family": "Weineland", "given": "Sandra", "initials": "S"}, {"family": "Ribbeg\u00e5rdh", "given": "Rasmus", "initials": "R"}, {"family": "Kivi", "given": "Marie", "initials": "M"}, {"family": "Bygdell", "given": "Andreas", "initials": "A"}, {"family": "Larsson", "given": "Anna", "initials": "A"}, {"family": "Vernmark", "given": "Kristofer", "initials": "K"}, {"family": "Lilja", "given": "Josefine L", "initials": "JL"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Internet Interv", "issn": "2214-7829", "volume": "22", "issue": null, "pages": "100356", "issn-l": "2214-7829"}, "abstract": "To address the increasing mental health problems among young people, health care needs to broaden the spectrum of interventions and increase access to care. One particularly promising first-line intervention is cognitive behavioral therapy (CBT) delivered via the Internet (iCBT). The outbreak of the Coronavirus disease -2019 (COVID -19) has made the need for solid digital mental health care systems clear. This is the first published study exploring the transition among therapists of working with face-to-face treatment to using iCBT for youths suffering from anxiety treated in primary care.\n\nFourteen primary care therapists were included in the study. Semi-structured interviews (n = 26) were conducted on two occasions: before starting to use iCBT for youths, and at a subsequent follow-up after gaining treatment experience. Data was summarized into thematic categories.\n\nThe overarching themes that were identified were: Attitudes to iCBT before and after implementation; Experiences of treatment delivery; Characteristics of \"the right patient;\" and The role of the digital therapist.\n\nThe participants generally had positive attitudes to iCBT for youths and saw it as a valuable alternative to face-to-face treatments. However, they identified challenges related to patient selection, and to motivating patients and maintaining a therapeutic relationship through mainly written communication. The participants appreciated the increase in variety that iCBT brought to their schedules, and also experienced iCBT as a relief from common challenges of therapeutic work, such as emotional stress and high cognitive demands. The participating therapists' positive experiences support the introduction of iCBT for youths in routine primary care.", "doi": "10.1016/j.invent.2020.100356", "pmid": "33318951", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2214-7829(20)30122-6"}, {"db": "pmc", "key": "PMC7724368"}], "notes": [], "created": "2020-12-21T10:10:30.198Z", "modified": "2021-02-26T08:46:59.868Z"}, {"entity": "publication", "iuid": "e15a41ecb1524431b4580ca26555b4fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e15a41ecb1524431b4580ca26555b4fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e15a41ecb1524431b4580ca26555b4fa"}}, "title": "Thromboembolism, Hypercoagulopathy, and Antiphospholipid Antibodies in Critically Ill Coronavirus Disease 2019 Patients: A Before and After Study of Enhanced Anticoagulation", "authors": [{"family": "van der Linden", "given": "Jan", "initials": "J"}, {"family": "Almskog", "given": "Lou", "initials": "L"}, {"family": "Liliequist", "given": "Andreas", "initials": "A"}, {"family": "Grip", "given": "Jonathan", "initials": "J"}, {"family": "Fux", "given": "Thomas", "initials": "T"}, {"family": "Rysz", "given": "Susanne", "initials": "S"}, {"family": "\u00c5gren", "given": "Anna", "initials": "A"}, {"family": "Oldner", "given": "Anders", "initials": "A"}, {"family": "St\u00e5hlberg", "given": "Marcus", "initials": "M"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "Crit Care Explorations", "issn": "2639-8028", "issn-l": null, "volume": "2", "issue": "12", "pages": "e0308"}, "abstract": null, "doi": "10.1097/cce.0000000000000308", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-08T09:33:38.702Z", "modified": "2021-02-26T08:45:48.796Z"}, {"entity": "publication", "iuid": "224a7ae30efa43aa81366a5ea538dbcd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/224a7ae30efa43aa81366a5ea538dbcd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/224a7ae30efa43aa81366a5ea538dbcd"}}, "title": "The first eight months of Sweden's COVID-19 strategy and the key actions and actors that were involved.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF", "orcid": "0000-0003-1024-5602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1d5e45881a7469ca20a0eb360d891cc.json"}}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": "109", "issue": "12", "pages": "2459-2471", "issn-l": "0803-5253"}, "abstract": "COVID-19 has affected millions of people worldwide. This paper reviews the Swedish pandemic response.\n\nA narrative review was carried out and a timeline constructed.\n\nBy September 1, 2020, 0.8% of Swedish residents had tested positive for the virus and 0.06% of the population had died, which was higher than neighbouring Nordic countries, but lower than some European countries with general lockdowns. The main actors were the Public Health Agency, the National Board of Health and Welfare, the Civil Contingencies Agency and the Government. County councils and regions implemented policies, in conjunction with the Department of Education and county administrative boards. Sweden's response was less invasive than many other countries, with no general lockdown. It focused on mitigation: slowing, but not stopping, the pandemic. Physical distancing was recommended in public spaces, but mandatory in bars, restaurants and at events. Visits to nursing facilities were banned. Kindergartens and schools for children up to 16 stayed open, but closed for older children for three months. There were no enforced quarantines for infected households or geographical regions, and facemasks were not recommended outside health care.\n\nSweden chose a different pandemic strategy to its peer nations. This paper examines the first eight months.", "doi": "10.1111/apa.15582", "pmid": "32951258", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7537539"}], "notes": [], "created": "2020-11-26T12:26:45.047Z", "modified": "2023-01-13T13:29:39.327Z"}, {"entity": "publication", "iuid": "3694aab447f0437394fb108e7234d197", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3694aab447f0437394fb108e7234d197.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3694aab447f0437394fb108e7234d197"}}, "title": "The effect of interventions on COVID-19.", "authors": [{"family": "Soltesz", "given": "Kristian", "initials": "K", "orcid": "0000-0001-6378-7646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/936add4190154f9a8642f999147592e2.json"}}, {"family": "Gustafsson", "given": "Fredrik", "initials": "F"}, {"family": "Timpka", "given": "Toomas", "initials": "T"}, {"family": "Jald\u00e9n", "given": "Joakim", "initials": "J"}, {"family": "Jidling", "given": "Carl", "initials": "C"}, {"family": "Heimerson", "given": "Albin", "initials": "A"}, {"family": "Sch\u00f6n", "given": "Thomas B", "initials": "TB", "orcid": "0000-0001-5183-234X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/749950fca61f4c5b8801f4f22928594f.json"}}, {"family": "Spreco", "given": "Armin", "initials": "A", "orcid": "0000-0003-0985-8209", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29a7cab23d784f898e1706bb138caa0f.json"}}, {"family": "Ekberg", "given": "Joakim", "initials": "J"}, {"family": "Dahlstr\u00f6m", "given": "\u00d6rjan", "initials": "\u00d6"}, {"family": "Bagge Carlson", "given": "Fredrik", "initials": "F"}, {"family": "J\u00f6ud", "given": "Anna", "initials": "A"}, {"family": "Bernhardsson", "given": "Bo", "initials": "B"}], "type": "letter", "published": "2020-12-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "588", "issue": "7839", "pages": "E26-E28", "issn-l": "0028-0836"}, "abstract": null, "doi": "10.1038/s41586-020-3025-y", "pmid": "33361787", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41586-020-3025-y"}], "notes": [], "created": "2021-01-07T13:41:51.776Z", "modified": "2023-06-19T14:58:31.467Z"}, {"entity": "publication", "iuid": "7b92975b1b11441f935557260a1414e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b92975b1b11441f935557260a1414e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b92975b1b11441f935557260a1414e1"}}, "title": "Swedish policy analysis for Covid-19.", "authors": [{"family": "Kavaliunas", "given": "Andrius", "initials": "A"}, {"family": "Ocaya", "given": "Pauline", "initials": "P"}, {"family": "Mumper", "given": "Jim", "initials": "J"}, {"family": "Lindfeldt", "given": "Isis", "initials": "I"}, {"family": "Kyhlstedt", "given": "Mattias", "initials": "M"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Health Policy Technol", "issn": "2211-8837", "volume": "9", "issue": "4", "pages": "598-612", "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has challenged health care systems and put societies to the test in the world beyond expectations.\n\nOur aim is to describe and analyze the Swedish approach in combating the pandemic.\n\nWe present and discuss data collated from various sources - published scientific studies, pre-print material, agency reports, media communication, public surveys, etc. - with specific focus on the approach itself, Covid-19 trends, healthcare system response, policy and measures overview, and implications.\n\nThe main intervention to manage the curve has been the general recommendations to adhere to good hand hygiene, beware of physical distance to others, to refrain from large gatherings and restrain from non-essential travel. Persons with suspected Covid-19 infection were recommended to stay at home and avoid social contacts. Additionally, visits to the elderly care homes and meetings with more than 50 people were forbidden. As a result, the healthcare system in the country has so far, never been overwhelmed. However, the relatively high mortality among the elderly, together with the vulnerability of some migrants, points out the drawbacks.\n\nMany countries have both marvelled and criticized the Swedish strategy that is formed in a close partnership between the government and the society based on a mutual trust giving the responsibility to individuals. It already highlights how much can be achieved with voluntary measures (recommendations) - something that was noticed and proposed as a future model by the World Health Organization.", "doi": "10.1016/j.hlpt.2020.08.009", "pmid": "32904437", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S2211-8837(20)30081-2"}, {"db": "pmc", "key": "PMC7455549"}], "notes": [], "created": "2020-12-03T16:15:28.228Z", "modified": "2021-02-26T08:46:13.289Z"}, {"entity": "publication", "iuid": "e5040817d84e42569eeb6b0d5b2509f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e5040817d84e42569eeb6b0d5b2509f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e5040817d84e42569eeb6b0d5b2509f8"}}, "title": "Simple technology for COVID-19 medical solid waste treatment in low-resourced settings.", "authors": [{"family": "Bellizzi", "given": "Saverio", "initials": "S"}, {"family": "Kamal", "given": "Sherif A", "initials": "SA"}, {"family": "Newir", "given": "Ahmed E", "initials": "AE"}, {"family": "Pichierri", "given": "Giuseppe", "initials": "G"}, {"family": "Salaris", "given": "Paola", "initials": "P"}, {"family": "Pinto", "given": "Sergio", "initials": "S"}, {"family": "Farina", "given": "Gabriele", "initials": "G"}, {"family": "Fiamma", "given": "Maura", "initials": "M"}, {"family": "Maher", "given": "Osama Ali", "initials": "OA"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Glob Health", "issn": "2047-2986", "issn-l": "2047-2978", "volume": "10", "issue": "2", "pages": "020373"}, "abstract": null, "doi": "10.7189/jogh.10.020373", "pmid": "33282215", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jogh-10-020373"}, {"db": "pmc", "key": "PMC7688062"}], "notes": [], "created": "2020-12-10T09:17:40.665Z", "modified": "2020-12-10T09:18:26.221Z"}, {"entity": "publication", "iuid": "7a458bc696174cd6892145beb010c9c6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a458bc696174cd6892145beb010c9c6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a458bc696174cd6892145beb010c9c6"}}, "title": "Renin\u2013angiotensin system blockers and susceptibility to COVID-19: an international, open science, cohort analysis", "authors": [{"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Conover", "given": "Mitchell M", "initials": "MM"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Pratt", "given": "Nicole", "initials": "N"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "Fern\u00e1ndez-Bertol\u00edn", "given": "Sergio", "initials": "S"}, {"family": "Arag\u00f3n", "given": "Maria", "initials": "M"}, {"family": "DuVall", "given": "Scott L", "initials": "SL"}, {"family": "Lynch", "given": "Kristine", "initials": "K"}, {"family": "Falconer", "given": "Thomas", "initials": "T"}, {"family": "van Bochove", "given": "Kees", "initials": "K"}, {"family": "Sung", "given": "Cynthia", "initials": "C"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Lambert", "given": "Christophe G", "initials": "CG"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Williams", "given": "Andrew E", "initials": "AE"}, {"family": "Park", "given": "Rae Woong", "initials": "RW"}, {"family": "Weaver", "given": "James", "initials": "J"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Schuemie", "given": "Martijn J", "initials": "MJ"}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR"}, {"family": "Williams", "given": "Ross D", "initials": "RD"}, {"family": "Lane", "given": "Jennifer C E", "initials": "JCE"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Krumholz", "given": "Harlan M", "initials": "HM"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Ryan", "given": "Patrick B", "initials": "PB"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "The Lancet Digital Health", "issn": "2589-7500", "issn-l": null, "volume": "3", "issue": "2", "pages": "e98-e114"}, "abstract": null, "doi": "10.1016/s2589-7500(20)30289-2", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://data.ohdsi.org/IcariusSusceptibility/", "description": "Data aggregated by data source"}], "notes": [], "created": "2021-01-10T18:07:44.284Z", "modified": "2021-04-26T18:00:54.936Z"}, {"entity": "publication", "iuid": "e3fd6fbf88d1478283f699293b003c91", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3fd6fbf88d1478283f699293b003c91.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3fd6fbf88d1478283f699293b003c91"}}, "title": "Real-World Issues and Potential Solutions in Hematopoietic Cell Transplantation during the COVID-19 Pandemic: Perspectives from the Worldwide Network for Blood and Marrow Transplantation and Center for International Blood and Marrow Transplant Research Health Services and International Studies Committee.", "authors": [{"family": "Algwaiz", "given": "Ghada", "initials": "G"}, {"family": "Aljurf", "given": "Mahmoud", "initials": "M"}, {"family": "Koh", "given": "Mickey", "initials": "M"}, {"family": "Horowitz", "given": "Mary M", "initials": "MM"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Weisdorf", "given": "Daniel", "initials": "D"}, {"family": "Saber", "given": "Wael", "initials": "W"}, {"family": "Kodera", "given": "Yoshihisa", "initials": "Y"}, {"family": "Szer", "given": "Jeff", "initials": "J"}, {"family": "Jawdat", "given": "Dunia", "initials": "D"}, {"family": "Wood", "given": "William A", "initials": "WA"}, {"family": "Brazauskas", "given": "Ruta", "initials": "R"}, {"family": "Lehmann", "given": "Leslie", "initials": "L"}, {"family": "Pasquini", "given": "Marcelo C", "initials": "MC"}, {"family": "Seber", "given": "Adriana", "initials": "A"}, {"family": "Lu", "given": "Pei Hua", "initials": "PH"}, {"family": "Atsuta", "given": "Yoshiko", "initials": "Y"}, {"family": "Riches", "given": "Marcie", "initials": "M"}, {"family": "Perales", "given": "Miguel-Angel", "initials": "M"}, {"family": "Worel", "given": "Nina", "initials": "N"}, {"family": "Okamoto", "given": "Shinichiro", "initials": "S"}, {"family": "Srivastava", "given": "Alok", "initials": "A"}, {"family": "Chemaly", "given": "Roy F", "initials": "RF"}, {"family": "Cordonnier", "given": "Catherine", "initials": "C"}, {"family": "Dandoy", "given": "Christopher E", "initials": "CE"}, {"family": "Wingard", "given": "John R", "initials": "JR"}, {"family": "Kharfan-Dabaja", "given": "Mohamed A", "initials": "MA"}, {"family": "Hamadani", "given": "Mehdi", "initials": "M"}, {"family": "Majhail", "given": "Navneet S", "initials": "NS"}, {"family": "Waghmare", "given": "Alpana A", "initials": "AA"}, {"family": "Chao", "given": "Nelson", "initials": "N"}, {"family": "Kr\u00f6ger", "given": "Nicolaus", "initials": "N"}, {"family": "Shaw", "given": "Bronwen", "initials": "B"}, {"family": "Mohty", "given": "Mohamad", "initials": "M"}, {"family": "Niederwieser", "given": "Dietger", "initials": "D"}, {"family": "Greinix", "given": "Hildegard", "initials": "H"}, {"family": "Hashmi", "given": "Shahrukh K", "initials": "SK"}, {"family": "WBMT and the CIBMTR Health Services and International Studies Committee", "given": "", "initials": ""}], "type": "practice guideline", "published": "2020-12-00", "journal": {"title": "Biol Blood Marrow Transplant", "issn": "1523-6536", "issn-l": null, "volume": "26", "issue": "12", "pages": "2181-2189"}, "abstract": "The current COVID-19 pandemic, caused by SARS-CoV-2, has impacted many facets of hematopoietic cell transplantation (HCT) in both developed and developing countries. Realizing the challenges as a result of this pandemic affecting the daily practice of the HCT centers and the recognition of the variability in practice worldwide, the Worldwide Network for Blood and Marrow Transplantation (WBMT) and the Center for International Blood and Marrow Transplant Research's (CIBMTR) Health Services and International Studies Committee have jointly produced an expert opinion statement as a general guide to deal with certain aspects of HCT, including diagnostics for SARS-CoV-2 in HCT recipient, pre- and post-HCT management, donor issues, medical tourism, and facilities management. During these crucial times, which may last for months or years, the HCT community must reorganize to proceed with transplantation activity in those patients who urgently require it, albeit with extreme caution. This shared knowledge may be of value to the HCT community in the absence of high-quality evidence-based medicine. \u00a9 2020 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.", "doi": "10.1016/j.bbmt.2020.07.021", "pmid": "32717432", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1083-8791(20)30454-7"}, {"db": "pmc", "key": "PMC7380217"}], "notes": [], "created": "2020-12-07T16:12:27.503Z", "modified": "2020-12-11T12:52:49.859Z"}, {"entity": "publication", "iuid": "b5f72594dbb84c7d80156fb4fe5230aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5f72594dbb84c7d80156fb4fe5230aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5f72594dbb84c7d80156fb4fe5230aa"}}, "title": "Prospective role of thyroid disorders in monitoring COVID-19 pandemic.", "authors": [{"family": "Kumari", "given": "Kanchan", "initials": "K", "orcid": "0000-0001-7546-4174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/895c82c727734e4a8adf3f47ebf52a8d.json"}}, {"family": "Chainy", "given": "Gagan B N", "initials": "GBN"}, {"family": "Subudhi", "given": "Umakanta", "initials": "U", "orcid": "0000-0002-8271-1513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32d7e301f9304e68aac214ef5bb30455.json"}}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": "6", "issue": "12", "pages": "e05712", "issn-l": null}, "abstract": "COVID-19 pandemic has affected more than 200 countries and 1.3 million individuals have deceased within eleven months. Intense research on COVID-19 occurrence and prevalence enable us to understand that comorbidities play a crucial role in spread and severity of SARS-CoV-2 infection. Chronic kidney disease, diabetes, respiratory diseases and hypertension are among the various morbidities that are prevalent in symptomatic COVID-19 patients. However, the effect of altered thyroid-driven disorders cannot be ignored. Since thyroid hormone critically coordinate and regulate the major metabolism and biochemical pathways, this review is on the potential role of prevailing thyroid disorders in SARS-CoV-2 infection. Direct link of thyroid hormone with several disorders such as diabetes, vitamin D deficiency, obesity, kidney and liver disorders etc. suggests that the prevailing thyroid conditions may affect SARS-CoV-2 infection. Further, we discuss the oxidative stress-induced aging is associated with the degree of SARS-CoV-2 infection. Importantly, ACE2 protein which facilitates the host-cell entry of SARS-CoV-2 using the spike protein, are highly expressed in individuals with abnormal level of thyroid hormone. Altogether, we report that the malfunction of thyroid hormone synthesis may aggravate SARS-CoV-2 infection and thus monitoring the thyroid hormone may help in understanding the pathogenesis of COVID-19.", "doi": "10.1016/j.heliyon.2020.e05712", "pmid": "33344794", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(20)32555-X"}, {"db": "pmc", "key": "PMC7733548"}], "notes": [], "created": "2021-01-10T17:31:22.639Z", "modified": "2021-06-22T13:25:34.955Z"}, {"entity": "publication", "iuid": "d72c2b773cbc47f3bdbf32b03b3158df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d72c2b773cbc47f3bdbf32b03b3158df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d72c2b773cbc47f3bdbf32b03b3158df"}}, "title": "Perspectives and Consensus among International Orthopaedic Surgeons during Initial and Mid-lockdown Phases of Coronavirus Disease.", "authors": [{"family": "Jerome", "given": "J Terrence Jose", "initials": "JTJ"}, {"family": "Mercier", "given": "Francisco", "initials": "F"}, {"family": "Mudgal", "given": "Chaitanya S", "initials": "CS"}, {"family": "Arenas-Prat", "given": "Joan", "initials": "J"}, {"family": "Vinagre", "given": "Gustavo", "initials": "G"}, {"family": "Goorens", "given": "Chul Ki", "initials": "CK"}, {"family": "Rivera-Chavarr\u00eda", "given": "Ignacio J", "initials": "IJ"}, {"family": "Sechachalam", "given": "Sreedharan", "initials": "S"}, {"family": "Mofikoya", "given": "Bolaji", "initials": "B"}, {"family": "Thoma", "given": "Achilleas", "initials": "A"}, {"family": "Medina", "given": "Claudia", "initials": "C"}, {"family": "IlavarasuTamilmani 13", "given": "", "initials": ""}, {"family": "Henry", "given": "Mark", "initials": "M"}, {"family": "Afshar", "given": "Ahmadreza", "initials": "A"}, {"family": "Dailiana", "given": "Zoe H", "initials": "ZH"}, {"family": "Prasetyono", "given": "Theddeus O H", "initials": "TOH"}, {"family": "Artiaco", "given": "Stefano", "initials": "S"}, {"family": "Madhusudhan", "given": "Thayur R", "initials": "TR"}, {"family": "Ukaj", "given": "Skender", "initials": "S"}, {"family": "Reigstad", "given": "Ole", "initials": "O"}, {"family": "Hamada", "given": "Yoshitaka", "initials": "Y"}, {"family": "Bedi", "given": "Rajesh", "initials": "R"}, {"family": "Poggetti", "given": "Andrea", "initials": "A"}, {"family": "Al-Qattan", "given": "Mohammad Manna", "initials": "MM"}, {"family": "Siala", "given": "Mahdi", "initials": "M"}, {"family": "Viswanathan", "given": "Anand", "initials": "A"}, {"family": "Romero-Reveron", "given": "Rafael", "initials": "R"}, {"family": "Hong", "given": "Joon Pio", "initials": "JP"}, {"family": "Khalid", "given": "Kamarul Ariffin", "initials": "KA"}, {"family": "Bhaskaran", "given": "Shivashankar", "initials": "S"}, {"family": "Venkatadass", "given": "Krishnamoorthy", "initials": "K"}, {"family": "Leechavengvongs", "given": "Somsak", "initials": "S"}, {"family": "Nazim", "given": "Sifi", "initials": "S"}, {"family": "Georgescu", "given": "Alexandru Valentin", "initials": "AV"}, {"family": "Tremp", "given": "Mathias", "initials": "M"}, {"family": "Nakarmi", "given": "Kiran K", "initials": "KK"}, {"family": "Ellabban", "given": "Mohamed A", "initials": "MA"}, {"family": "Chan", "given": "Pingtak", "initials": "P"}, {"family": "Aristov", "given": "Andrey", "initials": "A"}, {"family": "Patel", "given": "Sandeep", "initials": "S"}, {"family": "Moreno-Serrano", "given": "Constanza L", "initials": "CL"}, {"family": "Rai", "given": "Shwetabh", "initials": "S"}, {"family": "Kanna", "given": "Rishi Mugesh", "initials": "RM"}, {"family": "Malshikare", "given": "Vijay A", "initials": "VA"}, {"family": "Tanabe", "given": "Katsuhisa", "initials": "K"}, {"family": "Thomas", "given": "Simon", "initials": "S"}, {"family": "Gokkus", "given": "Kemal", "initials": "K"}, {"family": "Baek", "given": "Seung-Hoon", "initials": "SH"}, {"family": "Brandt", "given": "Jerker", "initials": "J"}, {"family": "Rith", "given": "Yin", "initials": "Y"}, {"family": "Olazabal", "given": "Alfredo", "initials": "A"}, {"family": "Saaiq", "given": "Muhammad", "initials": "M"}, {"family": "Patil", "given": "Vijay", "initials": "V"}, {"family": "Jithendran", "given": "N", "initials": "N"}, {"family": "Parekh", "given": "Harshil", "initials": "H"}, {"family": "Minamikawa", "given": "Yoshitaka", "initials": "Y"}, {"family": "Atagawi", "given": "Abdulljawad Almabrouk", "initials": "AA"}, {"family": "Hadi", "given": "Jalal Ahmed", "initials": "JA"}, {"family": "Berezowsky", "given": "Claudia Arroyo", "initials": "CA"}, {"family": "Moya-Angeler", "given": "Joaquin", "initials": "J"}, {"family": "Altamirano-Cruz", "given": "Marco Antonio", "initials": "MA"}, {"family": "Galvis R", "given": "Luz Adriana", "initials": "LA"}, {"family": "Antezana", "given": "Alex", "initials": "A"}, {"family": "Paczesny", "given": "Lukasz", "initials": "L"}, {"family": "Fernandes", "given": "Carlos Henrique", "initials": "CH"}, {"family": "Asadullah", "given": "Md", "initials": "M"}, {"family": "Yuan-Shun", "given": "Lo", "initials": "L"}, {"family": "Makelov", "given": "Biser", "initials": "B"}, {"family": "Dodakundi", "given": "Chaitanya", "initials": "C"}, {"family": "Regmi", "given": "Rabindra", "initials": "R"}, {"family": "Pereira", "given": "Ganarlo Urquizo", "initials": "GU"}, {"family": "Zhang", "given": "Shuwei", "initials": "S"}, {"family": "Sayoojianadhan", "given": "Binoy", "initials": "B"}, {"family": "Callupe", "given": "Ivan", "initials": "I"}, {"family": "Rakha", "given": "Mohamed I", "initials": "MI"}, {"family": "Papes", "given": "Dino", "initials": "D"}, {"family": "Ganesan", "given": "Ramesh Prabu", "initials": "RP"}, {"family": "Mohan", "given": "Mukesh", "initials": "M"}, {"family": "Jeyaraman", "given": "Arun", "initials": "A"}, {"family": "Prabhakar", "given": "Ponnaian", "initials": "P"}, {"family": "Rajniashokan", "given": "Arungeethayan", "initials": "A"}, {"family": "Geethan", "given": "I", "initials": "I"}, {"family": "Chandrasekar", "given": "Sugavanam", "initials": "S"}, {"family": "L\u00f6w", "given": "Steffen", "initials": "S"}, {"family": "Thangavelu", "given": "Kannan", "initials": "K"}, {"family": "Giudici", "given": "Luca Dei", "initials": "LD"}, {"family": "Palanisamy", "given": "Yuvarajan", "initials": "Y"}, {"family": "Vaidyanathan", "given": "Singaravadivelu", "initials": "S"}, {"family": "Boretto", "given": "Jorge", "initials": "J"}, {"family": "Ramirez", "given": "Monica Alexandra", "initials": "MA"}, {"family": "Goundar", "given": "Thirumalaisamy Subbiah", "initials": "TS"}, {"family": "Kuppusamy", "given": "Thirumavalavan", "initials": "T"}, {"family": "Kanniyan", "given": "Kalaivanan", "initials": "K"}, {"family": "Srivastava", "given": "Atul", "initials": "A"}, {"family": "Chiu", "given": "Yung-Cheng", "initials": "YC"}, {"family": "Bhat", "given": "Anil K", "initials": "AK"}, {"family": "Gopinath", "given": "Nalli R", "initials": "NR"}, {"family": "Vasudevan", "given": "Vijayaraghavan P", "initials": "VP"}, {"family": "Abraham", "given": "Vineet", "initials": "V"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Hand Microsurg", "issn": "0974-3227", "volume": "12", "issue": "3", "pages": "135-162", "issn-l": null}, "abstract": "With a lot of uncertainty, unclear, and frequently changing management protocols, COVID-19 has significantly impacted the orthopaedic surgical practice during this pandemic crisis. Surgeons around the world needed closed introspection, contemplation, and prospective consensual recommendations for safe surgical practice and prevention of viral contamination. One hundred orthopaedic surgeons from 50 countries were sent a Google online form with a questionnaire explicating protocols for admission, surgeries, discharge, follow-up, relevant information affecting their surgical practices, difficulties faced, and many more important issues that happened during and after the lockdown. Ten surgeons critically construed and interpreted the data to form rationale guidelines and recommendations. Of the total, hand and microsurgery surgeons (52%), trauma surgeons (32%), joint replacement surgeons (20%), and arthroscopy surgeons (14%) actively participated in the survey. Surgeons from national public health care/government college hospitals (44%) and private/semiprivate practitioners (54%) were involved in the study. Countries had lockdown started as early as January 3, 2020 with the implementation of partial or complete lifting of lockdown in few countries while writing this article. Surgeons (58%) did not stop their surgical practice or clinics but preferred only emergency cases during the lockdown. Most of the surgeons (49%) had three-fourths reduction in their total patients turn-up and the remaining cases were managed by conservative (54%) methods. There was a 50 to 75% reduction in the number of surgeries. Surgeons did perform emergency procedures without COVID-19 tests but preferred reverse transcription polymerase chain reaction (RT-PCR; 77%) and computed tomography (CT) scan chest (12%) tests for all elective surgical cases. Open fracture and emergency procedures (60%) and distal radius (55%) fractures were the most commonly performed surgeries. Surgeons preferred full personal protection equipment kits (69%) with a respirator (N95/FFP3), but in the case of unavailability, they used surgical masks and normal gowns. Regional/local anesthesia (70%) remained their choice for surgery to prevent the aerosolized risk of contaminations. Essential surgical follow-up with limited persons and visits was encouraged by 70% of the surgeons, whereas teleconsultation and telerehabilitation by 30% of the surgeons. Despite the protective equipment, one-third of the surgeons were afraid of getting infected and 56% feared of infecting their near and dear ones. Orthopaedic surgeons in private practice did face 50 to 75% financial loss and have to furlough 25% staff and 50% paramedical persons. Orthopaedics meetings were cancelled, and virtual meetings have become the preferred mode of sharing the knowledge and experiences avoiding human contacts. Staying at home, reading, and writing manuscripts became more interesting and an interesting lifestyle change is seen among the surgeons. Unanimously and without any doubt all accepted the fact that COVID-19 pandemic has reached an unprecedented level where personal hygiene, hand washing, social distancing, and safe surgical practices are the viable antidotes, and they have all slowly integrated these practices into their lives. Strict adherence to local authority recommendations and guidelines, uniform and standardized norms for admission, inpatient, and discharge, mandatory RT-PCR tests before surgery and in selective cases with CT scan chest, optimizing and regularizing the surgeries, avoiding and delaying nonemergency surgeries and follow-up protocols, use of teleconsultations cautiously, and working in close association with the World Health Organization and national health care systems will provide a conducive and safe working environment for orthopaedic surgeons and their fraternity and also will prevent the resurgence of COVID-19.", "doi": "10.1055/s-0040-1713964", "pmid": "33408440", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "JHAM2000002"}, {"db": "pmc", "key": "PMC7773504"}], "notes": [], "created": "2021-01-08T07:19:07.003Z", "modified": "2021-01-08T07:19:07.024Z"}, {"entity": "publication", "iuid": "d50e4d3b23964fd892c53f371c4552f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d50e4d3b23964fd892c53f371c4552f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d50e4d3b23964fd892c53f371c4552f4"}}, "title": "Nordic welfare states\u2014still standing or changed by the COVID \u201019 crisis?", "authors": [{"family": "Greve", "given": "Bent", "initials": "B"}, {"family": "Blomquist", "given": "Paula", "initials": "P"}, {"family": "Hvinden", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "van Gerven", "given": "Minna", "initials": "M"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "Soc Policy Adm", "issn": "0144-5596", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1111/spol.12675", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-10T17:26:19.225Z", "modified": "2021-02-26T08:47:00.226Z"}, {"entity": "publication", "iuid": "8471851f2f744e6081ff4dddaaf3a426", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8471851f2f744e6081ff4dddaaf3a426.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8471851f2f744e6081ff4dddaaf3a426"}}, "title": "Mechanisms of a Sustained Anti\u2010inflammatory Drug Response in Alveolar Macrophages Unraveled with Mathematical Modeling", "authors": [{"family": "Nyman", "given": "Elin", "initials": "E"}, {"family": "Lindh", "given": "Maria", "initials": "M"}, {"family": "L\u00f6vfors", "given": "William", "initials": "W"}, {"family": "Simonsson", "given": "Christian", "initials": "C"}, {"family": "Persson", "given": "Alexander", "initials": "A"}, {"family": "Eklund", "given": "Daniel", "initials": "D"}, {"family": "B\u00e4ckstr\u00f6m", "given": "Erica", "initials": "E"}, {"family": "Frid\u00e9n", "given": "Markus", "initials": "M"}, {"family": "Cedersund", "given": "Gunnar", "initials": "G"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "CPT Pharmacometrics Syst. Pharmacol.", "issn": "2163-8306", "issn-l": null, "volume": "9", "issue": "12", "pages": "707-717"}, "abstract": "Both initiation and suppression of inflammation are hallmarks of the immune response. If not balanced, the inflammation may cause extensive tissue damage, which is associated with common diseases, e.g., asthma and atherosclerosis. Anti-inflammatory drugs come with side effects that may be aggravated by high and fluctuating drug concentrations. To remedy this, an anti-inflammatory drug should have an appropriate pharmacokinetic half-life or better still, a sustained anti-inflammatory drug response. However, we still lack a quantitative mechanistic understanding of such sustained effects. Here, we study the anti-inflammatory response to a common glucocorticoid drug, dexamethasone. We find a sustained response 22 hours after drug removal. With hypothesis testing using mathematical modeling, we unravel the underlying mechanism-a slow release of dexamethasone from the receptor-drug complex. The developed model is in agreement with time-resolved training and testing data and is used to simulate hypothetical treatment schemes. This work opens up for a more knowledge-driven drug development to find sustained anti-inflammatory responses and fewer side effects.", "doi": "10.1002/psp4.12568", "pmid": "33217190", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Funder: H2020": null, "Category: Biochemistry": null, "Category: Other": null}, "xrefs": [{"db": "URL", "key": "https://gitlab.liu.se/eliny61/macrophage-model", "description": "Experimental data and data analysis code"}], "notes": [], "created": "2021-01-17T08:51:36.015Z", "modified": "2021-06-14T14:35:41.477Z"}, {"entity": "publication", "iuid": "8a9dd1c8ce0a4fdfba93cd57897cfde8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a9dd1c8ce0a4fdfba93cd57897cfde8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a9dd1c8ce0a4fdfba93cd57897cfde8"}}, "title": "MR1-Restricted T Cells with MAIT-like Characteristics Are Functionally Conserved in the Pteropid Bat Pteropus alecto", "authors": [{"family": "Leeansyah", "given": "Edwin", "initials": "E"}, {"family": "Hey", "given": "Ying Ying", "initials": "YY"}, {"family": "Sia", "given": "Wan Rong", "initials": "WR"}, {"family": "Ng", "given": "Justin Han Jia", "initials": "JHJ"}, {"family": "Gulam", "given": "Muhammad Yaaseen", "initials": "MY"}, {"family": "Boulouis", "given": "Caroline", "initials": "C"}, {"family": "Zhu", "given": "Feng", "initials": "F"}, {"family": "Ahn", "given": "Matae", "initials": "M"}, {"family": "Mak", "given": "Jeffrey Y W", "initials": "JYW"}, {"family": "Fairlie", "given": "David P", "initials": "DP"}, {"family": "Kwa", "given": "Andrea Lay Hoon", "initials": "ALH"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Wang", "given": "Lin Fa", "initials": "LF"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "iScience", "issn": "2589-0042", "issn-l": "2589-0042", "volume": "23", "issue": "12", "pages": "101876"}, "abstract": "Bats are reservoirs for a large number of viruses which have potential to cause major human disease outbreaks, including the current coronavirus disease 2019 (COVID-19) pandemic. Major efforts are underway to understand bat immune response to viruses, whereas much less is known about their immune responses to bacteria. In this study, MR1-restricted T (MR1T) cells were detected through the use of MR1 tetramers in circulation and tissues of Pteropus alecto (Pa) bats. Pa MR1T cells exhibited weak responses to MR1-presented microbial metabolites at resting state. However, following priming with MR1-presented agonist they proliferated, upregulated critical transcription factors and cytolytic proteins, and gained transient expression of Th1/17-related cytokines and antibacterial cytotoxicity. Collectively, these findings show that the Pa bat immune system encompasses an abundant and functionally conserved population of MR1T cells with mucosal-associated invariant T-like characteristics, suggesting that MR1 and MR1T cells also play a significant role in bat immune defense.", "doi": "10.1016/j.isci.2020.101876", "pmid": "33344919", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-01-08T08:31:48.988Z", "modified": "2021-02-26T08:45:03.126Z"}, {"entity": "publication", "iuid": "a08d95668e6d4fa392a1660710854a87", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a08d95668e6d4fa392a1660710854a87.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a08d95668e6d4fa392a1660710854a87"}}, "title": "Lessons from COVID-19 on the role of the state and the market in providing early testing.", "authors": [{"family": "Morel", "given": "Chantal M", "initials": "CM"}, {"family": "Lindahl", "given": "Olof", "initials": "O"}, {"family": "\u00d6zenci", "given": "Volkan", "initials": "V"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Glob Health", "issn": "2047-2986", "volume": "10", "issue": "2", "pages": "020330", "issn-l": "2047-2978"}, "abstract": null, "doi": "10.7189/jogh.10.020330", "pmid": "33110530", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "jogh-10-020330"}, {"db": "pmc", "key": "PMC7561275"}], "notes": [], "created": "2020-11-19T19:29:19.519Z", "modified": "2020-11-27T10:22:50.060Z"}, {"entity": "publication", "iuid": "f568a85ab627477b80bcfb16151c32a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f568a85ab627477b80bcfb16151c32a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f568a85ab627477b80bcfb16151c32a1"}}, "title": "Laboratory management for SARS-CoV-2 detection: a user-friendly combination of the heat treatment approach and rt-Real-time PCR testing.", "authors": [{"family": "Mancini", "given": "Fabiola", "initials": "F"}, {"family": "Barbanti", "given": "Fabrizio", "initials": "F"}, {"family": "Scaturro", "given": "Maria", "initials": "M"}, {"family": "Errico", "given": "Giulia", "initials": "G"}, {"family": "Iacobino", "given": "Angelo", "initials": "A"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Marsili", "given": "Giulia", "initials": "G"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Rezza", "given": "Giovanni", "initials": "G"}, {"family": "Ciervo", "given": "Alessandra", "initials": "A"}, {"family": "on behalf ISS COVID-19 study group", "given": "", "initials": ""}], "type": "evaluation study", "published": "2020-12-00", "journal": {"title": "Emerg Microbes Infect", "issn": "2222-1751", "volume": "9", "issue": "1", "pages": "1393-1396", "issn-l": "2222-1751"}, "abstract": "The RNA purification is the gold standard for the detection of SARS-CoV-2 in swab samples, but it is dependent on the availability of chemical reagents. In this study, we evaluated the heat treatment method without RNA extraction as a reliable option to nucleic acid purification.", "doi": "10.1080/22221751.2020.1775500", "pmid": "32552549", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7473159"}], "notes": [], "created": "2020-12-09T07:49:54.116Z", "modified": "2021-02-26T08:46:13.606Z"}, {"entity": "publication", "iuid": "31658bdf82964e28bf165148ff841709", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/31658bdf82964e28bf165148ff841709.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/31658bdf82964e28bf165148ff841709"}}, "title": "Incidence and outcome of myocardial infarction treated with percutaneous coronary intervention during COVID-19 pandemic.", "authors": [{"family": "Mohammad", "given": "Moman A", "initials": "MA"}, {"family": "Koul", "given": "Sasha", "initials": "S"}, {"family": "Olivecrona", "given": "G\u00f6ran K", "initials": "GK"}, {"family": "G\u04e7tberg", "given": "Matthias", "initials": "M"}, {"family": "Tyd\u00e9n", "given": "Patrik", "initials": "P"}, {"family": "Rydberg", "given": "Erik", "initials": "E"}, {"family": "Scherst\u00e9n", "given": "Fredrik", "initials": "F"}, {"family": "Alfredsson", "given": "Joakim", "initials": "J"}, {"family": "Vasko", "given": "Peter", "initials": "P"}, {"family": "Omerovic", "given": "Elmir", "initials": "E"}, {"family": "Anger\u00e5s", "given": "Oskar", "initials": "O"}, {"family": "Fr\u00f6bert", "given": "Ole", "initials": "O"}, {"family": "Calais", "given": "Fredrik", "initials": "F"}, {"family": "V\u00f6lz", "given": "Sebastian", "initials": "S"}, {"family": "Ulvenstam", "given": "Anders", "initials": "A"}, {"family": "Venetsanos", "given": "Dimitrios", "initials": "D"}, {"family": "Yndigegn", "given": "Troels", "initials": "T"}, {"family": "Oldgren", "given": "Jonas", "initials": "J"}, {"family": "Sarno", "given": "Giovanna", "initials": "G"}, {"family": "Grimfj\u00e4rd", "given": "Per", "initials": "P"}, {"family": "Persson", "given": "Jonas", "initials": "J"}, {"family": "Witt", "given": "Nils", "initials": "N"}, {"family": "Ostenfeld", "given": "Ellen", "initials": "E"}, {"family": "Lindahl", "given": "Bertil", "initials": "B"}, {"family": "James", "given": "Stefan K", "initials": "SK"}, {"family": "Erlinge", "given": "David", "initials": "D"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Heart", "issn": "1468-201X", "issn-l": null, "volume": "106", "issue": "23", "pages": "1812-1818"}, "abstract": "Most reports on the declining incidence of myocardial infarction (MI) during the COVID-19 have either been anecdotal, survey results or geographically limited to areas with lockdowns. We examined the incidence of MI during the COVID-19 pandemic in Sweden, which has remained an open society with a different public health approach fighting COVID-19.\r\n\r\nWe assessed the incidence rate (IR) as well as the incidence rate ratios (IRRs) of all MI referred for coronary angiography in Sweden using the nationwide Swedish Coronary Angiography and Angioplasty Registry (SCAAR), during the COVID-19 pandemic in Sweden (1 March 2020-7 May 2020) in relation to the same days 2015-2019.\r\n\r\nA total of 2443 MIs were referred for coronary angiography during the COVID-19 pandemic resulting in an IR 36 MIs/day (204 MIs/100 000 per year) compared with 15 213 MIs during the reference period with an IR of 45 MIs/day (254 MIs/100 000 per year) resulting in IRR of 0.80, 95% CI (0.74 to 0.86), p<0.001. Results were consistent in all investigated patient subgroups, indicating no change in patient category seeking cardiac care. Kaplan-Meier event rates for 7-day case fatality were 439 (2.3%) compared with 37 (2.9%) (HR: 0.81, 95% CI (0.58 to 1.13), p=0.21). Time to percutaneous coronary intervention (PCI) was shorter during the pandemic and PCI was equally performed, indicating no change in quality of care during the pandemic.\r\n\r\nThe COVID-19 pandemic has significantly reduced the incidence of MI referred for invasive treatment strategy. No differences in overall short-term case fatality or quality of care indicators were observed.", "doi": "10.1136/heartjnl-2020-317685", "pmid": "33023905", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "heartjnl-2020-317685"}, {"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-12-01T18:13:48.157Z", "modified": "2021-02-26T08:46:59.885Z"}, {"entity": "publication", "iuid": "6aa068c605fd4b8bbbdbdb4c583803aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6aa068c605fd4b8bbbdbdb4c583803aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6aa068c605fd4b8bbbdbdb4c583803aa"}}, "title": "In Conversation with a Frontline Worker in a Care Home in Sweden during the COVID-19 Pandemic.", "authors": [{"family": "Kabir", "given": "Zarina N", "initials": "ZN"}, {"family": "Bostr\u00f6m", "given": "Anne-Marie", "initials": "A"}, {"family": "Konradsen", "given": "Hanne", "initials": "H"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Cross Cult Gerontol", "issn": "1573-0719", "issn-l": null, "volume": "35", "issue": "4", "pages": "493-500"}, "abstract": null, "doi": "10.1007/s10823-020-09415-7", "pmid": "33015728", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10823-020-09415-7"}, {"db": "pmc", "key": "PMC7533166"}], "notes": [], "created": "2020-12-03T08:52:20.615Z", "modified": "2022-11-23T09:03:41.112Z"}, {"entity": "publication", "iuid": "19007ffe053f4ce0a17b43ea23ac2ff0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19007ffe053f4ce0a17b43ea23ac2ff0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19007ffe053f4ce0a17b43ea23ac2ff0"}}, "title": "Impact of COVID-19 in paediatric early-phase cancer clinical trials in Europe: A report from the Innovative Therapies for Children with Cancer (ITCC) consortium.", "authors": [{"family": "Rubio-San-Sim\u00f3n", "given": "Alba", "initials": "A"}, {"family": "Andr\u00e9", "given": "Nicolas", "initials": "N"}, {"family": "Cefalo", "given": "Maria Giuseppina", "initials": "MG"}, {"family": "Aerts", "given": "Isabelle", "initials": "I"}, {"family": "Casta\u00f1eda", "given": "Alicia", "initials": "A"}, {"family": "Benezech", "given": "Sarah", "initials": "S"}, {"family": "Makin", "given": "Guy", "initials": "G"}, {"family": "van Eijkelenburg", "given": "Natasha", "initials": "N"}, {"family": "Nysom", "given": "Karsten", "initials": "K"}, {"family": "Marshall", "given": "Lynley", "initials": "L"}, {"family": "Gambart", "given": "Marion", "initials": "M"}, {"family": "Hladun", "given": "Raquel", "initials": "R"}, {"family": "Rossig", "given": "Claudia", "initials": "C"}, {"family": "Bergamaschi", "given": "Luca", "initials": "L"}, {"family": "Fagioli", "given": "Franca", "initials": "F"}, {"family": "Carpenter", "given": "Ben", "initials": "B"}, {"family": "Ducassou", "given": "Stephane", "initials": "S"}, {"family": "Owens", "given": "Cormac", "initials": "C"}, {"family": "\u00d8ra", "given": "Ingrid", "initials": "I"}, {"family": "Ribelles", "given": "Antonio Juan", "initials": "AJ"}, {"family": "De Wilde", "given": "Bram", "initials": "B"}, {"family": "Guerra-Garc\u00eda", "given": "Pilar", "initials": "P"}, {"family": "Strullu", "given": "Marion", "initials": "M"}, {"family": "Rizzari", "given": "Carmelo", "initials": "C"}, {"family": "Ek", "given": "Torben", "initials": "T"}, {"family": "Hettmer", "given": "Simone", "initials": "S"}, {"family": "Gerber", "given": "Nicolas U", "initials": "NU"}, {"family": "Rawlings", "given": "Christine", "initials": "C"}, {"family": "Diezi", "given": "Manuel", "initials": "M"}, {"family": "Palmu", "given": "Sauli", "initials": "S"}, {"family": "Ruggiero", "given": "Antonio", "initials": "A"}, {"family": "Verd\u00fa", "given": "Jaime", "initials": "J"}, {"family": "de Rojas", "given": "Teresa", "initials": "T"}, {"family": "Vassal", "given": "Gilles", "initials": "G"}, {"family": "Geoerger", "given": "Birgit", "initials": "B"}, {"family": "Moreno", "given": "Lucas", "initials": "L"}, {"family": "Bautista", "given": "Francisco", "initials": "F"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Eur J Cancer", "issn": "1879-0852", "issn-l": "0959-8049", "volume": "141", "issue": null, "pages": "82-91"}, "abstract": "Data regarding real-world impact on cancer clinical research during COVID-19 are scarce. We analysed the impact of the COVID-19 pandemic on the conduct of paediatric cancer phase I-II trials in Europe through the experience of the Innovative Therapies for Children with Cancer (ITCC).\r\n\r\nA survey was sent to all ITCC-accredited early-phase clinical trial hospitals including questions about impact on staff activities, recruitment, patient care, supply of investigational products and legal aspects, between 1st March and 30th April 2020.\r\n\r\nThirty-one of 53 hospitals from 12 countries participated. Challenges reported included staff constraints (30% drop), reduction in planned monitoring activity (67% drop of site initiation visits and 64% of monitoring visits) and patient recruitment (61% drop compared with that in 2019). The percentage of phase I, phase II trials and molecular platforms closing to recruitment in at least one site was 48.5%, 61.3% and 64.3%, respectively. In addition, 26% of sites had restrictions on performing trial assessments because of local contingency plans. Almost half of the units suffered impact upon pending contracts. Most hospitals (65%) are planning on improving organisational and structural changes.\r\n\r\nThe study reveals a profound disruption of paediatric cancer early-phase clinical research due to the COVID-19 pandemic across Europe. Reported difficulties affected both patient care and monitoring activity. Efforts should be made to reallocate resources to avoid lost opportunities for patients and to allow the continued advancement of oncology research. Identified adaptations to clinical trial procedures may be integrated to increase preparedness of clinical research to futures crises.", "doi": "10.1016/j.ejca.2020.09.024", "pmid": "33129040", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0959-8049(20)31029-7"}, {"db": "pmc", "key": "PMC7546235"}], "notes": [], "created": "2020-12-01T15:02:28.027Z", "modified": "2021-02-26T08:46:59.838Z"}, {"entity": "publication", "iuid": "a4de5d5c53974077a4b1cc5e40718bfd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a4de5d5c53974077a4b1cc5e40718bfd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a4de5d5c53974077a4b1cc5e40718bfd"}}, "title": "Guidance regarding COVID-19 for survivors of childhood, adolescent, and young adult cancer: A statement from the International Late Effects of Childhood Cancer Guideline Harmonization Group.", "authors": [{"family": "Verbruggen", "given": "Lisanne C", "initials": "LC"}, {"family": "Wang", "given": "Yuehan", "initials": "Y"}, {"family": "Armenian", "given": "Saro H", "initials": "SH"}, {"family": "Ehrhardt", "given": "Matthew J", "initials": "MJ"}, {"family": "van der Pal", "given": "Helena J H", "initials": "HJH"}, {"family": "van Dalen", "given": "Elvira C", "initials": "EC"}, {"family": "van As", "given": "Jorrit W", "initials": "JW"}, {"family": "Bardi", "given": "Edit", "initials": "E"}, {"family": "Baust", "given": "Katja", "initials": "K"}, {"family": "Berger", "given": "Claire", "initials": "C"}, {"family": "Castagnola", "given": "Elio", "initials": "E"}, {"family": "Devine", "given": "Katie A", "initials": "KA"}, {"family": "Gebauer", "given": "Judith", "initials": "J"}, {"family": "Marchak", "given": "Jordan Gilleland", "initials": "JG"}, {"family": "Glaser", "given": "Adam W", "initials": "AW"}, {"family": "Groll", "given": "Andreas H", "initials": "AH"}, {"family": "Haeusler", "given": "Gabrielle M", "initials": "GM"}, {"family": "den Hartogh", "given": "Jaap", "initials": "J"}, {"family": "Haupt", "given": "Riccardo", "initials": "R"}, {"family": "Hjorth", "given": "Lars", "initials": "L"}, {"family": "Kato", "given": "Miho", "initials": "M"}, {"family": "Kep\u00e1k", "given": "Tom\u00e1\u0161", "initials": "T"}, {"family": "Koopman", "given": "Maria M W Rianne", "initials": "MMWR"}, {"family": "Langer", "given": "Thorsten", "initials": "T"}, {"family": "Maeda", "given": "Miho", "initials": "M"}, {"family": "Michel", "given": "Gisela", "initials": "G"}, {"family": "Muraca", "given": "Monica", "initials": "M"}, {"family": "Nathan", "given": "Paul C", "initials": "PC"}, {"family": "van den Oever", "given": "Selina R", "initials": "SR"}, {"family": "Pavasovic", "given": "Vesna", "initials": "V"}, {"family": "Sato", "given": "Satomi", "initials": "S"}, {"family": "Schulte", "given": "Fiona", "initials": "F"}, {"family": "Sung", "given": "Lillian", "initials": "L"}, {"family": "Tissing", "given": "Wim", "initials": "W"}, {"family": "Uyttebroeck", "given": "Anne", "initials": "A"}, {"family": "Mulder", "given": "Ren\u00e9e L", "initials": "RL"}, {"family": "Kuehni", "given": "Claudia", "initials": "C"}, {"family": "Skinner", "given": "Roderick", "initials": "R"}, {"family": "Hudson", "given": "Melissa M", "initials": "MM"}, {"family": "Kremer", "given": "Leontien C M", "initials": "LCM"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Pediatr Blood Cancer", "issn": "1545-5017", "volume": "67", "issue": "12", "pages": "e28702", "issn-l": null}, "abstract": "Childhood, adolescent, and young adult (CAYA) cancer survivors may be at risk for a severe course of COVID-19. Little is known about the clinical course of COVID-19 in CAYA cancer survivors, or if additional preventive measures are warranted. We established a working group within the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) to summarize existing evidence and worldwide recommendations regarding evidence about factors/conditions associated with risk for a severe course of COVID-19 in CAYA cancer survivors, and to develop a consensus statement to provide guidance for healthcare practitioners and CAYA cancer survivors regarding COVID-19.", "doi": "10.1002/pbc.28702", "pmid": "32969160", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7537044"}], "notes": [], "created": "2020-12-03T15:09:18.905Z", "modified": "2020-12-03T15:09:45.512Z"}, {"entity": "publication", "iuid": "7bfa4880a578414c8706043aed8fc6e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7bfa4880a578414c8706043aed8fc6e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7bfa4880a578414c8706043aed8fc6e7"}}, "title": "Good old BCG - what a century-old vaccine can contribute to modern medicine.", "authors": [{"family": "Locht", "given": "C", "initials": "C"}, {"family": "Lerm", "given": "M", "initials": "M"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": "288", "issue": "6", "pages": "611-613", "issn-l": null}, "abstract": null, "doi": "10.1111/joim.13195", "pmid": "33315299", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-21T10:17:15.240Z", "modified": "2021-01-08T12:32:15.992Z"}, {"entity": "publication", "iuid": "379f21c57926472b8d4a756b34ca57bb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/379f21c57926472b8d4a756b34ca57bb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/379f21c57926472b8d4a756b34ca57bb"}}, "title": "Feasibility of telehealth in the management of autoimmune hepatitis before and during the COVID-19 pandemic.", "authors": [{"family": "Efe", "given": "Cumali", "initials": "C"}, {"family": "Sim\u015fek", "given": "Cem", "initials": "C"}, {"family": "Bat\u0131bay", "given": "Ersin", "initials": "E"}, {"family": "Cal\u0131\u015fkan", "given": "Ali R\u0131za", "initials": "AR"}, {"family": "Wahlin", "given": "Staffan", "initials": "S"}], "type": "comparative study", "published": "2020-12-00", "journal": {"title": "Expert Rev Gastroenterol Hepatol", "issn": "1747-4132", "issn-l": null, "volume": "14", "issue": "12", "pages": "1215-1219"}, "abstract": "We aimed to evaluate the feasibility of telehealth in the management of patients with autoimmune hepatitis (AIH). The COVID-19 outbreak during the study period provided an opportunity to evaluate any pandemic influence on how telehealth was perceived by patients and physicians.\r\n\r\nWe included patients with AIH who were followed in the Harran University hospital, Turkey. Patients were managed by either remote telehealth or standard care.\r\n\r\nA total of 46 (telehealth, n=19 and standard care, n= 27) patients (40 female) with a median age of 32 (range 17-74) years at diagnosis were included in the study. Until the start of the COVID-19 pandemic, the rates of biochemical remission and relapse after remission were similar in the telehealth and standard care groups (89.5% vs. 89.1% and 15.8% vs. 25.9%, p=ns, for both). The telehealth group maintained remission significantly better than the standard care group (100% vs. 77.3%, p=0.035) during the COVID-19 period. All relapses were due to non-adherence to therapy. Psychiatric problems, pregnancy-related issues and drug side-effects could all be managed remotely by telehealth.\r\n\r\nIn this study, we show for the first time that telehealth is a feasible alternative for managing AIH, both under normal circumstances and during the COVID-19 pandemic.\r\n\r\nAutoimmune hepatitis (AIH) requires long-life lifelong immunosuppression and follow-up for most patients. The use of telehealth may be an alternative way to evaluate these patients remotely. We show for the first time that telehealth is effective and useful in the management of AIH in regular time as well during COVID-19. We hope that our study can extend use of telehealth in the evaluation of patients with other causes of chronic liver disease.", "doi": "10.1080/17474124.2020.1822734", "pmid": "32909852", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2020-12-03T15:51:11.527Z", "modified": "2021-02-26T08:46:59.903Z"}, {"entity": "publication", "iuid": "9f6673a28f7a47d5a6129c5e51f0dcfd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f6673a28f7a47d5a6129c5e51f0dcfd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f6673a28f7a47d5a6129c5e51f0dcfd"}}, "title": "Factors related to preventive COVID-19 infection behaviors among people with mental illness.", "authors": [{"family": "Chang", "given": "Kun-Chia", "initials": "K"}, {"family": "Strong", "given": "Carol", "initials": "C"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Formos Med Assoc", "issn": "0929-6646", "issn-l": null, "volume": "119", "issue": "12", "pages": "1772-1780"}, "abstract": "Because of the spread of novel coronavirus disease 2019 (COVID-2019), preventive COVID-19 infection behaviors become important for individuals, especially those who are vulnerable. The present study proposes a model to explain the preventive COVID-19 infection behaviors among people with mental illness in Taiwan.\r\n\r\nA cross-sectional design was carried out and 414 patients with mental illness (230 males [55.6%]; mean age = 46.32 [SD = 10.86]) agreed to participate in the study. All the participants completed the Preventive COVID-19 Infection Behaviors Scale, Self-Stigma Scale-Short, Believing COVID-19 Information Scale, Fear of COVID-19 Scale, and Depression Anxiety Stress Scale-21. Regression models and structural equation modeling (SEM) were applied to examine the factors associated with preventive COVID-19 infection behaviors.\r\n\r\nBoth regression models and SEM showed that trust in COVID-19 information sources (standardized coefficient [\u03b2] = 0.211 in regression; \u03b2 = 0.194 in SEM) and fear of COVID-19 (\u03b2 = -0.128 in regression; \u03b2 = -0.223 in SEM) significantly explained preventive behaviors among individuals with mental illness. The SEM further showed that fear of COVID-19 was significantly explained by trust in COVID-19 information sources (\u03b2 = 0.220) and self-stigma (\u03b2 = 0.454).\r\n\r\nBased on the results, healthcare providers should help individuals with mental illness reduce self-stigma and fear of COVID-19 which would consequently improve their preventive COVID-19 infection behaviors. Moreover, improving trust in COVID-19 information sources for individuals with mental illness may be another method to improve their preventive behaviors.", "doi": "10.1016/j.jfma.2020.07.032", "pmid": "32773260", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0929-6646(20)30344-2"}, {"db": "pmc", "key": "PMC7388748"}], "notes": [], "created": "2020-12-07T13:33:24.123Z", "modified": "2021-02-26T08:47:00.110Z"}, {"entity": "publication", "iuid": "ca7515e94a4946148ea2fe65f49320d8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ca7515e94a4946148ea2fe65f49320d8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ca7515e94a4946148ea2fe65f49320d8"}}, "title": "Epidemiological characteristics of COVID-19 cases and estimates of the reproductive numbers 1 month into the epidemic, Italy, 28 January to 31 March 2020.", "authors": [{"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Ajelli", "given": "Marco", "initials": "M"}, {"family": "Andrianou", "given": "Xanthi D", "initials": "XD"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Bellino", "given": "Stefania", "initials": "S"}, {"family": "Boros", "given": "Stefano", "initials": "S"}, {"family": "Urdiales", "given": "Alberto Mateo", "initials": "AM"}, {"family": "Marziano", "given": "Valentina", "initials": "V"}, {"family": "Rota", "given": "Maria Cristina", "initials": "MC"}, {"family": "Filia", "given": "Antonietta", "initials": "A"}, {"family": "D'Ancona", "given": "Fortunato", "initials": "F"}, {"family": "Siddu", "given": "Andrea", "initials": "A"}, {"family": "Punzo", "given": "Ornella", "initials": "O"}, {"family": "Trentini", "given": "Filippo", "initials": "F"}, {"family": "Guzzetta", "given": "Giorgio", "initials": "G"}, {"family": "Poletti", "given": "Piero", "initials": "P"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Castrucci", "given": "Maria Rita", "initials": "MR"}, {"family": "Ciervo", "given": "Alessandra", "initials": "A"}, {"family": "Di Benedetto", "given": "Corrado", "initials": "C"}, {"family": "Tallon", "given": "Marco", "initials": "M"}, {"family": "Piccioli", "given": "Andrea", "initials": "A"}, {"family": "Brusaferro", "given": "Silvio", "initials": "S"}, {"family": "Rezza", "given": "Giovanni", "initials": "G"}, {"family": "Merler", "given": "Stefano", "initials": "S"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "COVID-19 working group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "49", "issn-l": null}, "abstract": "BackgroundOn 20 February 2020, a locally acquired coronavirus disease (COVID-19) case was detected in Lombardy, Italy. This was the first signal of ongoing transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the country. The number of cases in Italy increased rapidly and the country became the first in Europe to experience a SARS-CoV-2 outbreak.AimOur aim was to describe the epidemiology and transmission dynamics of the first COVID-19 cases in Italy amid ongoing control measures.MethodsWe analysed all RT-PCR-confirmed COVID-19 cases reported to the national integrated surveillance system until 31 March 2020. We provide a descriptive epidemiological summary and estimate the basic and net reproductive numbers by region.ResultsOf the 98,716 cases of COVID-19 analysed, 9,512 were healthcare workers. Of the 10,943 reported COVID-19-associated deaths (crude case fatality ratio: 11.1%) 49.5% occurred in cases older than 80 years. Male sex and age were independent risk factors for COVID-19 death. Estimates of R 0 varied between 2.50 (95% confidence interval (CI): 2.18-2.83) in Tuscany and 3.00 (95% CI: 2.68-3.33) in Lazio. The net reproduction number Rt in northern regions started decreasing immediately after the first detection.ConclusionThe COVID-19 outbreak in Italy showed a clustering onset similar to the one in Wuhan, China. R0 at 2.96 in Lombardy combined with delayed detection explains the high case load and rapid geographical spread. Overall, Rt in Italian regions showed early signs of decrease, with large diversity in incidence, supporting the importance of combined non-pharmacological control measures.", "doi": "10.2807/1560-7917.ES.2020.25.49.2000790", "pmid": "33303064", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2020-12-13T07:20:07.307Z", "modified": "2021-02-26T08:47:00.193Z"}, {"entity": "publication", "iuid": "1e5d9f78dde24cba9062f2039ddf6fd7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1e5d9f78dde24cba9062f2039ddf6fd7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1e5d9f78dde24cba9062f2039ddf6fd7"}}, "title": "Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells.", "authors": [{"family": "Appelberg", "given": "Sofia", "initials": "S"}, {"family": "Gupta", "given": "Soham", "initials": "S"}, {"family": "Svensson Akusj\u00e4rvi", "given": "Sara", "initials": "S"}, {"family": "Ambikan", "given": "Anoop T", "initials": "AT"}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "Saccon", "given": "Elisa", "initials": "E"}, {"family": "V\u00e9gv\u00e1ri", "given": "\u00c1kos", "initials": "\u00c1"}, {"family": "Benfeitas", "given": "Rui", "initials": "R"}, {"family": "Sperk", "given": "Maike", "initials": "M"}, {"family": "St\u00e5hlberg", "given": "Marie", "initials": "M"}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Singh", "given": "Kamal", "initials": "K"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Emerg Microbes Infect", "issn": "2222-1751", "issn-l": "2222-1751", "volume": "9", "issue": "1", "pages": "1748-1760"}, "abstract": "How severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections engage cellular host pathways and innate immunity in infected cells remains largely elusive. We performed an integrative proteo-transcriptomics analysis in SARS-CoV-2 infected Huh7 cells to map the cellular response to the invading virus over time. We identified four pathways, ErbB, HIF-1, mTOR and TNF signaling, among others that were markedly modulated during the course of the SARS-CoV-2 infection in vitro. Western blot validation of the downstream effector molecules of these pathways revealed a dose-dependent activation of Akt, mTOR, S6K1 and 4E-BP1 at 24 hours post infection (hpi). However, we found a significant inhibition of HIF-1\u03b1 through 24hpi and 48hpi of the infection, suggesting a crosstalk between the SARS-CoV-2 and the Akt/mTOR/HIF-1 signaling pathways. Inhibition of the mTOR signaling pathway using Akt inhibitor MK-2206 showed a significant reduction in virus production. Further investigations are required to better understand the molecular sequelae in order to guide potential therapy in the management of severe coronavirus disease 2019 (COVID-19) patients.", "doi": "10.1080/22221751.2020.1799723", "pmid": "32691695", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "SRA", "key": "PRJNA627100", "description": "Raw RNAseq data"}, {"db": "URL", "key": "10.5281/zenodo.3754718", "description": "Proteomic data"}, {"db": "URL", "key": "https://github.com/neogilab/COVID19", "description": "Data analysis code"}], "notes": [], "created": "2020-11-18T16:47:18.250Z", "modified": "2021-02-26T08:45:47.926Z"}, {"entity": "publication", "iuid": "05363d49d5664a15846bc90192ce1f7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/05363d49d5664a15846bc90192ce1f7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/05363d49d5664a15846bc90192ce1f7e"}}, "title": "Development and external validation of a COVID-19 mortality risk prediction algorithm: a multicentre retrospective cohort study", "authors": [{"family": "Mei", "given": "Jin", "initials": "J"}, {"family": "Hu", "given": "Weihua", "initials": "W"}, {"family": "Chen", "given": "Qijian", "initials": "Q"}, {"family": "Li", "given": "Chang", "initials": "C"}, {"family": "Chen", "given": "Zaishu", "initials": "Z"}, {"family": "Fan", "given": "Yanjie", "initials": "Y"}, {"family": "Tian", "given": "Shuwei", "initials": "S"}, {"family": "Zhang", "given": "Zhuheng", "initials": "Z"}, {"family": "Li", "given": "Bin", "initials": "B"}, {"family": "Ye", "given": "Qifa", "initials": "Q"}, {"family": "Yue", "given": "Jiang", "initials": "J"}, {"family": "Wang", "given": "Qiao Li", "initials": "QL"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "10", "issue": "12", "pages": "e044028", "issn-l": "2044-6055"}, "abstract": null, "doi": "10.1136/bmjopen-2020-044028", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-10T17:29:16.471Z", "modified": "2021-02-26T08:46:59.808Z"}, {"entity": "publication", "iuid": "75453bffbf5d4bd8809071c66b55abe7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/75453bffbf5d4bd8809071c66b55abe7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/75453bffbf5d4bd8809071c66b55abe7"}}, "title": "Depression, anxiety, and stress mediate the associations between internet gaming disorder, insomnia, and quality of life during the COVID-19 outbreak.", "authors": [{"family": "Fazeli", "given": "Sara", "initials": "S"}, {"family": "Mohammadi Zeidi", "given": "Isa", "initials": "I"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Namdar", "given": "Peyman", "initials": "P"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Addict Behav Rep", "issn": "2352-8532", "issn-l": null, "volume": "12", "issue": null, "pages": "100307"}, "abstract": "For many individuals, the COVID-19 outbreak has increased their psychological distress, changed their behaviors, and impacted their health. With more time spent indoors, many individuals have engaged in increased videogame playing. However, the associations between such behaviors during the COVID-19 outbreak period is unclear.\r\n\r\nThe present study examined the mediating role of psychological distress (depression, anxiety, and stress) in the association between internet gaming disorder (IGD) and two health outcomes (insomnia quality of life) among adolescents during this COVID-19 pandemic.\r\n\r\nA cross-sectional study comprising adolescents ( N = 1512) aged 13-18 years (mean age = 15.51 years) was utilized to assess measures on insomnia, depression, anxiety, and stress, IGD, and quality of life during the COVID-19 pandemic.\r\n\r\nThere were small to large significant relationships between the variables. Psychological distress (i.e., depression, anxiety, and stress) served as a strong mediator in the association between IGD and insomnia and quality of life. IGD directly influenced insomnia and quality of life among the participants.\r\n\r\nIGD is associated with different psychosocial outcomes comprising multiple pathways. Parents need to pay special attention to how much time and how frequently their children play videogames. Parents may need to assist their children in coping with psychological distress during the ongoing COVID-19 pandemic period.", "doi": "10.1016/j.abrep.2020.100307", "pmid": "33110934", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S2352-8532(20)30122-X"}, {"db": "pmc", "key": "PMC7581367"}], "notes": [], "created": "2020-12-01T15:13:19.560Z", "modified": "2022-11-23T09:04:00.250Z"}, {"entity": "publication", "iuid": "aa40739fe513445582a64d793c977c8c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aa40739fe513445582a64d793c977c8c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aa40739fe513445582a64d793c977c8c"}}, "title": "Creating and applying SIR modified compartmental model for calculation of COVID-19 lockdown efficiency.", "authors": [{"family": "Sharov", "given": "Konstantin S", "initials": "KS"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Chaos Solitons Fractals", "issn": "0960-0779", "volume": "141", "issue": null, "pages": "110295", "issn-l": null}, "abstract": "We propose a Susceptible-Infected-Recovered (SIR) modified model for Coronavirus disease - 2019 (COVID-19) spread to estimate the efficacy of lockdown measures introduced during the pandemic. As input data, we used COVID-19 epidemiological information collected in fifteen European countries either in private surveys or using official statistics. Thirteen countries implemented lockdown measures, two countries (Sweden, Iceland) not. As output parameters, we studied herd immunity level and time of formation. Comparison of these parameters was used as an indicator of effectiveness / ineffectiveness of lockdown measures. In the absence of a medical vaccine, herd immunity may be regarded as a factor of population adaptation to severe acute respiratory syndrome-related coronavirus-2, the viral pathogen causing COVID-19 disease (SARS-CoV-2), and hence COVID-19 spreading stop. We demonstrated that there is no significant difference between lockdown and no-lockdown modes of COVID-19 containment, in terms of both herd immunity level and the time of achieving its maximum. The rationale for personal and business lockdowns may be found in the avoidance of healthcare system overburdening. However, lockdowns do not prevent any virus with droplet transmission (including SARS-CoV-2) from spreading. Therefore, in case of a future viral pathogen emergence, lockdown measures efficiency should not be overestimated, as it was done almost universally in the world during COVID-19 pandemic.", "doi": "10.1016/j.chaos.2020.110295", "pmid": "32994671", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0960-0779(20)30691-3"}, {"db": "pmc", "key": "PMC7513696"}], "notes": [], "created": "2020-12-03T09:02:25.737Z", "modified": "2021-02-26T08:46:13.423Z"}, {"entity": "publication", "iuid": "f7940db8b9524e11ac7837dfecd62eaa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7940db8b9524e11ac7837dfecd62eaa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7940db8b9524e11ac7837dfecd62eaa"}}, "title": "Corrigendum to \"Depression, anxiety, and stress mediate the associations between internet gaming disorder, insomnia, and quality of life during the COVID-19 outbreak\" [Addict. Behav. Rep. 12 (2020) 100307].", "authors": [{"family": "Fazeli", "given": "Sara", "initials": "S"}, {"family": "Zeidi", "given": "Isa Mohammadi", "initials": "IM"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Namdar", "given": "Peyman", "initials": "P"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Pakpour", "given": "Amir", "initials": "A"}], "type": "published erratum", "published": "2020-12-00", "journal": {"title": "Addict Behav Rep", "issn": "2352-8532", "volume": "12", "issue": null, "pages": "100322", "issn-l": null}, "abstract": "[This corrects the article DOI: 10.1016/j.abrep.2020.100307.].", "doi": "10.1016/j.abrep.2020.100322", "pmid": "33364329", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2352-8532(20)30137-1"}, {"db": "pmc", "key": "PMC7752708"}], "notes": [], "created": "2021-01-07T13:39:25.551Z", "modified": "2021-01-10T17:24:39.710Z"}, {"entity": "publication", "iuid": "dd5e75653bbc4f49a1f4579c267db46f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dd5e75653bbc4f49a1f4579c267db46f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dd5e75653bbc4f49a1f4579c267db46f"}}, "title": "COVID-19 and Possible Pharmacological Preventive Options.", "authors": [{"family": "Duner", "given": "Pontus", "initials": "P"}, {"family": "Salehi", "given": "Albert", "initials": "A"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Clin Med Res", "issn": "1918-3003", "issn-l": null, "volume": "12", "issue": "12", "pages": "758-772"}, "abstract": "The dreadful fear of the coronavirus disease 2019 (COVID-19), which is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with the deadly consequences, requires rapid development of pharmacological cures. The objective of this review is to speculate about possible pharmacological options, already available today to prevent or treat the COVID-19 in the early stage of its outbreak. A literature search across PubMed and internet was conducted. A number of studies dealing with COVID-19 were identified. The data elucidated that increased pro-inflammatory and decreased anti-inflammatory cytokines in combination with hypoxia, thromboembolism and pneumonia are involved in the pathogenesis of SARS-CoV-2 infection. Although many drugs has been tested in monotherapy regimen with varying outcome or without desirable effect, there is still hope for better results by simultaneously targeting the virus itself and its symptoms. Theoretically, a mixture of at least two available antiviral drugs in combination with other anti-pathogenic and immune system-enhancing drugs or combination of antiviral drugs with convalescent plasma seems likely to have much better effect than the monotherapy regimen of either of these drugs.", "doi": "10.14740/jocmr4383", "pmid": "33447309", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7781281"}], "notes": [], "created": "2021-01-15T13:08:11.011Z", "modified": "2021-07-14T07:51:34.954Z"}, {"entity": "publication", "iuid": "f4072870300d4088af6f5c7d2c45b82e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f4072870300d4088af6f5c7d2c45b82e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f4072870300d4088af6f5c7d2c45b82e"}}, "title": "COVID-19 and NSAIDS: A Narrative Review of Knowns and Unknowns.", "authors": [{"family": "Pergolizzi", "given": "Joseph V", "initials": "JV"}, {"family": "Varrassi", "given": "Giustino", "initials": "G"}, {"family": "Magnusson", "given": "Peter", "initials": "P"}, {"family": "LeQuang", "given": "Jo Ann", "initials": "JA"}, {"family": "Paladini", "given": "Antonella", "initials": "A"}, {"family": "Taylor", "given": "Robert", "initials": "R"}, {"family": "Wollmuth", "given": "Charles", "initials": "C"}, {"family": "Breve", "given": "Frank", "initials": "F"}, {"family": "Christo", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Pain Ther", "issn": "2193-8237", "volume": "9", "issue": "2", "pages": "353-358", "issn-l": null}, "abstract": "Concern about the appropriate role of nonsteroidal anti-inflammatory drugs (NSAIDs) in COVID-19 speculate that NSAIDs, in particular ibuprofen, may upregulate the entry point for the virus, the angiotensin-converting enzyme (ACE) 2 receptors and increase susceptibility to the virus or worsen symptoms in existing disease. Adverse outcomes with COVID-19 have been linked to cytokine storm but the most effective way to address exaggerated inflammatory response is complex and unclear. The Expert Working Group on the Commission of Human Medicines in the UK and other organizations have stated that there is insufficient evidence to establish a link between ibuprofen and susceptibility to or exacerbation of COVID-19. NSAID use must also be categorized by whether the drugs are relatively low-dose over-the-counter oral products taken occasionally versus higher-dose or parenteral NSAIDs. Even if evidence emerged arguing for or against NSAIDs in this setting, it is unclear if this evidence would apply to all NSAIDs at all doses in all dosing regimens. Paracetamol (acetaminophen) has been proposed as an alternative to NSAIDs but there are issues with liver toxicity at high doses. There are clearly COVID-19 cases where NSAIDs should not be used, but there is no strong evidence that NSAIDs must be avoided in all patients with COVID-19; clinicians must weigh these choices on an individual basis.", "doi": "10.1007/s40122-020-00173-5", "pmid": "32447629", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40122-020-00173-5"}, {"db": "pmc", "key": "PMC7245573"}], "notes": [], "created": "2020-11-25T09:13:50.558Z", "modified": "2020-11-30T09:03:27.305Z"}, {"entity": "publication", "iuid": "887e076a51704634b4f27fc6fbf095bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/887e076a51704634b4f27fc6fbf095bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/887e076a51704634b4f27fc6fbf095bd"}}, "title": "Blood type A associates with critical COVID-19 and death in a Swedish cohort", "authors": [{"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Persson", "given": "Barbro", "initials": "B"}, {"family": "Eriksson", "given": "Oskar", "initials": "O"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Nilsson", "given": "Bo", "initials": "B"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "Crit Care", "issn": "1364-8535", "issn-l": null, "volume": "24", "issue": "1", "pages": "496"}, "abstract": "No abstract available", "doi": "10.1186/s13054-020-03223-8", "pmid": "32787887", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Funder: VR: Special COVID-19 funding": null, "Category: Serology": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-10-30T12:03:20.383Z", "modified": "2022-02-14T06:44:05.982Z"}, {"entity": "publication", "iuid": "688925461d514ca8ba840a2028fdbcbc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/688925461d514ca8ba840a2028fdbcbc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/688925461d514ca8ba840a2028fdbcbc"}}, "title": "Amyloid nomenclature 2020: update and recommendations by the International Society of Amyloidosis (ISA) nomenclature committee.", "authors": [{"family": "Benson", "given": "Merrill D", "initials": "MD"}, {"family": "Buxbaum", "given": "Joel N", "initials": "JN"}, {"family": "Eisenberg", "given": "David S", "initials": "DS"}, {"family": "Merlini", "given": "Giampaolo", "initials": "G"}, {"family": "Saraiva", "given": "Maria J M", "initials": "MJM"}, {"family": "Sekijima", "given": "Yoshiki", "initials": "Y"}, {"family": "Sipe", "given": "Jean D", "initials": "JD"}, {"family": "Westermark", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Amyloid", "issn": "1744-2818", "volume": "27", "issue": "4", "pages": "217-222", "issn-l": null}, "abstract": "The ISA Nomenclature Committee met electronically before and directly after the XVII ISA International Symposium on Amyloidosis, which, unfortunately, had to be virtual in September 2020 due to the ongoing COVID-19 pandemic instead of a planned meeting in Tarragona in March. In addition to confirmation of basic nomenclature, several additional concepts were discussed, which are used in scientific amyloid literature. Among such concepts are cytotoxic oligomers, protofibrils, primary and secondary nucleation, seeding and cross-seeding, amyloid signature proteins, and amyloid plaques. Recommendations for their use are given. Definitions of amyloid and amyloidosis are confirmed. Possible novel human amyloid fibril proteins, appearing as 'classical' in vivo amyloid, were discussed. It was decided to include fibulin-like extracellular matrix protein 1 (amyloid protein: AEFEMP1), which appears as localised amyloid in portal veins. There are several possible amyloid proteins under investigation, and these are included in a new Table.", "doi": "10.1080/13506129.2020.1835263", "pmid": "33100054", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-01T15:32:13.763Z", "modified": "2020-12-01T15:32:13.783Z"}, {"entity": "publication", "iuid": "e7deb7bc299b44baa345a5adadb72799", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e7deb7bc299b44baa345a5adadb72799.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e7deb7bc299b44baa345a5adadb72799"}}, "title": "A timely update of global COVID-19 vaccine development.", "authors": [{"family": "Klavinskis", "given": "Linda S", "initials": "LS"}, {"family": "Liu", "given": "Margaret A", "initials": "MA"}, {"family": "Lu", "given": "Shan", "initials": "S"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Emerg Microbes Infect", "issn": "2222-1751", "issn-l": "2222-1751", "volume": "9", "issue": "1", "pages": "2379-2380"}, "abstract": "Commentary\r\nThis commentary provides an overview and links to presentations of a recent virtual congress series organized by the International Society for Vaccines (ISV) focused on COVID-19 vaccines. The series provided the academic community and vaccine developers as well as the wider general public with balanced information of the global response and resources for COVID-19 vaccines under development featuring: 1) NGOs and the regulatory perspective, 2) the status of vaccine development efforts, and 3) panel discussions to present and discuss challenges. ISV is a non-profit scientific organization whose members work on all areas relevant to vaccines. ISV plans to host additional virtual symposia including regional meetings and incorporating other topics along with COVID-19 vaccines.", "doi": "10.1080/22221751.2020.1838246", "pmid": "33059515", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7605319"}], "notes": [], "created": "2020-12-01T17:09:58.043Z", "modified": "2020-12-01T17:10:16.674Z"}, {"entity": "publication", "iuid": "eacb488d3071417b9b63d43c96028d43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eacb488d3071417b9b63d43c96028d43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eacb488d3071417b9b63d43c96028d43"}}, "title": "A systematic review and meta-analysis of the use of renin-angiotensin system drugs and COVID-19 clinical outcomes: What is the evidence so far?", "authors": [{"family": "Kurdi", "given": "Amanj", "initials": "A"}, {"family": "Abutheraa", "given": "Nouf", "initials": "N"}, {"family": "Akil", "given": "Lina", "initials": "L"}, {"family": "Godman", "given": "Brian", "initials": "B"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Pharmacol Res Perspect", "issn": "2052-1707", "volume": "8", "issue": "6", "pages": "e00666", "issn-l": "2052-1707"}, "abstract": "Conflicting evidence exists about the effect of angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs) on COVID-19 clinical outcomes. We aimed to provide a comprehensive/updated evaluation of the effect of ACEIs/ARBs on COVID-19-related clinical outcomes, including exploration of interclass differences between ACEIs and ARBs, using a systematic review/meta-analysis approach conducted in Medline (OVID), Embase, Scopus, Cochrane library, and medRxiv from inception to 22 May 2020. English studies that evaluated the effect of ACEIs/ARBs among patients with COVID-19 were included. Studies' quality was appraised using the Newcastle-Ottawa Scale. Data were analyzed using the random-effects modeling stratified by exposure (ACEIs/ARBs, ACEIs, and ARBs). Heterogeneiity was assessed using I 2 statistic. Several subgroup analyses were conducted to explore the impact of potential confounders. Overall, 27 studies were eligible. The pooled analyses showed nonsignificant associations between ACEIs/ARBs and death (OR:0.97, 95%CI:0.75,1.27), ICU admission (OR:1.09;95%CI:0.65,1.81), death/ICU admission (OR:0.67; 95%CI:0.52,0.86), risk of COVID-19 infection (OR:1.01; 95%CI:0.93,1.10), severe infection (OR:0.78; 95%CI:0.53,1.15), and hospitalization (OR:1.15; 95%CI:0.81,1.65). However, the subgroup analyses indicated significant association between ACEIs/ARBs and hospitalization among USA studies (OR:1.59; 95%CI:1.03,2.44), peer-reviewed (OR:1.93, 95%CI:1.38,2.71), good quality and studies which reported adjusted measure of effect (OR:1.30, 95%CI:1.10,1.50). Significant differences were found between ACEIs and ARBs with the latter being significantly associated with lower risk of acquiring COVID-19 infection (OR:0.24; 95%CI: 0.17,0.34). In conclusion, high-quality evidence exists for the effect of ACEIs/ARBs on some COVID-19 clinical outcomes. For the first time, we provided evidence, albeit of low quality, on interclass differences between ACEIs and ARBs for some of the reported clinical outcomes.", "doi": "10.1002/prp2.666", "pmid": "33084232", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7575889"}], "notes": [], "created": "2020-11-26T12:18:33.090Z", "modified": "2020-11-27T11:47:58.870Z"}, {"entity": "publication", "iuid": "22808e8b71744f5eaceaef8395f820f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/22808e8b71744f5eaceaef8395f820f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/22808e8b71744f5eaceaef8395f820f2"}}, "title": "A population-based nationwide dataset concerning the COVID-19 pandemic and serious psychological consequences in Bangladesh", "authors": [{"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Al Mamun", "given": "Firoj", "initials": "F"}, {"family": "Hosen", "given": "Ismail", "initials": "I"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "Data Brief", "issn": "2352-3409", "volume": "33", "issue": null, "pages": "106621", "issn-l": null}, "abstract": "This paper presents the dataset concerning knowledge, preventive behavior, psychological consequences, and suicidal behavior regarding the COVID-19 pandemic in Bangladesh. Data were collected through an online based cross-sectional survey between April 1 and April 10 in 64 districts at the early stage of the COVID-19 pandemic in Bangladesh. A total of 10,067 participants' data were recruited for analysis. The survey contained items concerning (i) socio-demographic information, (ii) knowledge concerning COVID-19, (iii) behavior towards COVID-19, (iv) lockdown and economic issues, (v) assessment of fear of COVID-19, (vi) assessment of insomnia, (vii) assessment of depression, and (viii) assessment of suicidal ideation. Data were analyzed utilizing SPSS (version 22) and are represented as frequencies and percentages based on responses to the whole survey. Given that the data were collected across the whole nation, government authorities and healthcare policymakers can use the data to develop various models and/or policies regarding preventive strategies and help raise awareness through health education towards COVID-19.", "doi": "10.1016/j.dib.2020.106621", "pmid": "33344737", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.7910/DVN/YKH9C1", "description": "Raw dataset: socio-demographic characteristics, sources of information regarding COVID-19, knowledge concerning COVID-19, behavior in preventing COVID-19, etc. (N=10,067)"}, {"db": "URL", "key": "https://ars.els-cdn.com/content/image/1-s2.0-S2352340920315018-mmc1.docx", "description": "Detailed description of all study variables"}], "notes": [], "created": "2021-01-08T08:32:42.091Z", "modified": "2021-02-26T08:46:59.856Z"}, {"entity": "publication", "iuid": "a887d824552b43858617ee072044d692", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a887d824552b43858617ee072044d692.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a887d824552b43858617ee072044d692"}}, "title": "The Precision Health and Everyday Democracy (PHED) Project: Protocol for a Transdisciplinary Collaboration on Health Equity and the Role of Health in Society.", "authors": [{"family": "Strange", "given": "Michael", "initials": "M"}, {"family": "Nilsson", "given": "Carol", "initials": "C"}, {"family": "Zdravkovic", "given": "Slobodan", "initials": "S"}, {"family": "Mangrio", "given": "Elisabeth", "initials": "E"}], "type": "journal article", "published": "2020-11-30", "journal": {"title": "JMIR Res Protoc", "issn": "1929-0748", "volume": "9", "issue": "11", "pages": "e17324", "issn-l": null}, "abstract": "The project \"Precision Health and Everyday Democracy\" (PHED) is a transdisciplinary partnership that combines a diverse range of perspectives necessary for understanding the increasingly complex societal role played by modern health care and medical research. The term \"precision health\" is being increasingly used to express the need for greater awareness of environmental and genomic characteristics that may lead to divergent health outcomes between different groups within a population. Enhancing awareness of diversity has parallels with calls for \"health democracy\" and greater patient-public participation within health care and medical research. Approaching health care in this way goes beyond a narrow focus on the societal determinants of health, since it requires considering health as a deliberative space, which occurs often at the banal or everyday level. As an initial empirical focus, PHED is directed toward the health needs of marginalized migrants (including refugees and asylum seekers, as well as migrants with temporary residency, often involving a legally or economically precarious situation) as vulnerable groups that are often overlooked by health care. Developing new transdisciplinary knowledge on these groups provides the potential to enhance their wellbeing and benefit the wider society through challenging the exclusions of these groups that create pockets of extreme ill-health, which, as we see with COVID-19, should be better understood as \"acts of self-harm\" for the wider negative impact on humanity.\n\nWe aim to establish and identify precision health strategies, as well as promote equal access to quality health care, drawing upon knowledge gained from studying the health care of marginalized migrants.\n\nThe project is based in Sweden at Malm\u00f6 and Lund Universities. At the outset, the network activities do not require ethical approval where they will not involve data collection, since the purpose of PHED is to strengthen international research contacts, establish new research within precision strategies, and construct educational research activities for junior colleagues within academia. However, whenever new research is funded and started, ethical approval for that specific data collection will be sought.\n\nThe PHED project has been funded from January 1, 2019. Results of the transdisciplinary collaboration will be disseminated via a series of international conferences, workshops, and web-based materials. To ensure the network project advances toward applied research, a major goal of dissemination is to produce tools for applied research, including information to enhance health accessibility for vulnerable communities, such as marginalized migrant populations in Sweden.\n\nThere is a need to identify tools to enable the prevention and treatment of a wide spectrum of health-related outcomes and their link to social as well as environmental issues. There is also a need to identify and investigate barriers to precision health based on democratic principles.\n\nDERR1-10.2196/17324.", "doi": "10.2196/17324", "pmid": "33252352", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "v9i11e17324"}], "notes": [], "created": "2020-12-03T08:24:10.169Z", "modified": "2020-12-03T08:24:10.192Z"}, {"entity": "publication", "iuid": "9159f26c8905426ba3599eaf2c635be2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9159f26c8905426ba3599eaf2c635be2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9159f26c8905426ba3599eaf2c635be2"}}, "title": "The COVID-19 pandemic: consequences for nephrology.", "authors": [{"family": "Bruchfeld", "given": "Annette", "initials": "A"}], "type": "journal article", "published": "2020-11-30", "journal": {"title": "Nat Rev Nephrol", "issn": "1759-507X", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1038/s41581-020-00381-4", "pmid": "33257872", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41581-020-00381-4"}], "notes": [], "created": "2020-12-03T08:18:19.455Z", "modified": "2020-12-03T08:18:19.476Z"}, {"entity": "publication", "iuid": "7aeabc3750d1481bb578d56cb544837a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7aeabc3750d1481bb578d56cb544837a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7aeabc3750d1481bb578d56cb544837a"}}, "title": "Rapid review of suspected adverse drug events due to remdesivir in the WHO database; findings and implications.", "authors": [{"family": "Charan", "given": "Jaykaran", "initials": "J"}, {"family": "Kaur", "given": "Rimple Jeet", "initials": "RJ"}, {"family": "Bhardwaj", "given": "Pankaj", "initials": "P"}, {"family": "Haque", "given": "Mainul", "initials": "M"}, {"family": "Sharma", "given": "Praveen", "initials": "P"}, {"family": "Misra", "given": "Sanjeev", "initials": "S"}, {"family": "Godman", "given": "Brian", "initials": "B"}], "type": "journal article", "published": "2020-11-30", "journal": {"title": "Expert Rev Clin Pharmacol", "issn": "1751-2441", "volume": null, "issue": null, "issn-l": null}, "abstract": "Objectives: Remdesivir has shown promise in the management of patients with COVID-19 although recent studies have shown concerns with its effectiveness in practice. Despite this there is a need to document potential adverse drug events (ADEs) to guide future decisions as limited ADE data available before COVID-19 pandemic. Methods: Interrogation of WHO VigiBase\u00ae from 2015 to 2020 coupled with published studies of ADEs in COVID-19 patients. The main outcome measures are the extent of ADEs broken down by factors including age, seriousness, region and organ. Results: A total 1086 ADEs were reported from the 439 individual case reports up to 19 July 2020 in the VigiBase\u00ae, reduced to 1004 once duplicates were excluded. Almost all ADEs concerned COVID-19 patients (92.5%), with an appreciable number from the Americas (67.7%). The majority of ADEs were from males > 45 years and were serious (82.5%). An increase in hepatic enzymes (32.1%), renal injury (14.4%), rise in creatinine levels (11.2%) respiratory failure (6.4%) were the most frequently reported ADEs. Conclusions: Deterioration of liver and kidney function are frequently observed ADEs with remdesivir; consequently, patients should be monitored for these ADEs. The findings are in line with ADEs included in regulatory authority documents.", "doi": "10.1080/17512433.2021.1856655", "pmid": "33252992", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-12-03T08:22:50.485Z", "modified": "2020-12-03T08:22:50.508Z"}, {"entity": "publication", "iuid": "647022ddc42941beab3d22a7d0a54b73", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/647022ddc42941beab3d22a7d0a54b73.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/647022ddc42941beab3d22a7d0a54b73"}}, "title": "Intracerebral endotheliitis and microbleeds are neuropathological features of COVID-19.", "authors": [{"family": "Kirschenbaum", "given": "Daniel", "initials": "D"}, {"family": "Imbach", "given": "Lukas L", "initials": "LL"}, {"family": "Jane Rushing", "given": "Elisabeth", "initials": "E"}, {"family": "Frauenknecht", "given": "Katrin B M", "initials": "KBM"}, {"family": "Gascho R T", "given": "Dominic", "initials": "D"}, {"family": "Victor Ineichen", "given": "Benjamin", "initials": "B"}, {"family": "Keller", "given": "Emanuela", "initials": "E"}, {"family": "Kohler", "given": "Sibylle", "initials": "S"}, {"family": "Lichtblau", "given": "Mona", "initials": "M"}, {"family": "Reimann", "given": "Regina R", "initials": "RR"}, {"family": "Schreib", "given": "Katharina", "initials": "K"}, {"family": "Ulrich", "given": "Silvia", "initials": "S"}, {"family": "Steiger", "given": "Peter", "initials": "P"}, {"family": "Aguzzi", "given": "Adriano", "initials": "A"}, {"family": "Frontzek", "given": "Karl", "initials": "K"}], "type": "journal article", "published": "2020-11-29", "journal": {"title": "Neuropathol Appl Neurobiol", "issn": "1365-2990", "volume": null, "issue": null, "issn-l": null}, "abstract": "Coronavirus disease 19 (COVID-19), caused by infection with the severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2), has become a worldwide pandemic (1). Symptoms of COVID-19 vary widely and range from asymptomatic disease to severe pneumonia and multiorgan failure (2). A severe disease course is more likely in older patients and patients with pre-existing respiratory and cardiovascular conditions (2). Patients with severe Sars-CoV-2 infection may present with ischaemic stroke (3, 4) or even fatal intracerebral haemorrhage (5). To date, little is known about the neuropathological sequelae of COVID-19. The largest published autopsy series of COVID-19 neuropathology reported microthrombi and acute haemorrhagic infarction in a significant number of patients (6), while another more recent study found evidence of lymphocytic encephalitis and meningitis (7). Endotheliitis of the brain and extraneural organs has been shown in Sars-CoV infected patients (8). Similarly, it is a recurrent feature in the lungs and other peripheral organs of Sars-CoV-2 infected patients (9) but has not yet been reported in the central nervous system. We speculated that cerebrovascular pathology in COVID-19 patients could be a direct consequence of hitherto unidentified cerebral endotheliitis caused by Sars-CoV-2.", "doi": "10.1111/nan.12677", "pmid": "33249605", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Provided in the article: Clinical and pathological characteristics of four patients", "description": null}], "notes": [], "created": "2020-11-30T07:48:09.681Z", "modified": "2021-02-26T08:45:48.255Z"}, {"entity": "publication", "iuid": "6c4ea2411cc242ddb5a2d67e6bbbf015", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c4ea2411cc242ddb5a2d67e6bbbf015.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c4ea2411cc242ddb5a2d67e6bbbf015"}}, "title": "The impact of COVID-19 pandemic on pornography habits: a global analysis of Google Trends.", "authors": [{"family": "Zattoni", "given": "Fabio", "initials": "F"}, {"family": "G\u00fcl", "given": "Murat", "initials": "M"}, {"family": "Soligo", "given": "Matteo", "initials": "M"}, {"family": "Morlacco", "given": "Alessandro", "initials": "A"}, {"family": "Motterle", "given": "Giovanni", "initials": "G"}, {"family": "Collavino", "given": "Jeanlou", "initials": "J"}, {"family": "Barneschi", "given": "Andrea Celeste", "initials": "AC"}, {"family": "Moschini", "given": "Marco", "initials": "M"}, {"family": "Moro", "given": "Fabrizio Dal", "initials": "FD"}], "type": "journal article", "published": "2020-11-28", "journal": {"title": "Int J Impot Res", "issn": "1476-5489", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "As the COVID-19 spread globally, social distancing, self-isolation/quarantine, and national lockdowns have become crucial to control the pandemic. However, these measures may also lead to increases in social isolation, loneliness, and stress, which can alter the consumption of pornography habits. The aim of the study was thus to explore the interest pattern in pornography and coronavirus-themed pornography during the COVID-19 outbreak. Google Trends\u00ae was employed to determine the most popular porn websites (Porn, XNXX, PornHub, xVideos, and xHamster), and coronavirus-themed pornography worldwide and in six nations with different COVID-19 outbreak and self-isolation recommendations. We analyzed every search trend on Google\u00ae from January 9, 2020 to May 25, 2020 using \"joint point regression analysis\". Comparisons of week relative search volume (WRSV) and temporal patterns were analyzed to assess the change of interest in search terms during nations lockdowns. Paired t-test was used to compare WRSV values among the porn websites during the national lockdowns and the equivalent timespan of the weeks in the previous 4 years. The research trend of almost every keyword increased with significant inflection points for those nations with a straight \"stay at home orders\" (China, Italy, Spain, and France). \"PornHub\" and \"Porn\" showed the highest increase of interest worldwide with an average weekend percentage change (AWPC) of 4.9 and 3.8, respectively. The mean WRSV for keywords in USA and Sweden did not show a similar increase as the other nations. The WRSV percentage change with the historical data had a peak during the straight nations' lockdowns (p < 0.01). All the nations had a significant increase in WRSV coronavirus-themed pornography for each keyword (p < 0.01) with an AWPC, ranging worldwide between 18.5 and 61.8 (p < 0.01), after the beginning of self-quarantine. As strengths this study uses a big data technology to collect worldwide trend of interest, however, data are anonymous and do not allow analysis of subpopulation groups. In conclusion, we demonstrated an increased interest in pornography and coronavirus-themed pornography after the outbreak of COVID-19 in nations with a straight \"stay at home orders\".", "doi": "10.1038/s41443-020-00380-w", "pmid": "33249423", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2020-11-30T07:47:06.936Z", "modified": "2022-11-23T09:04:21.537Z"}, {"entity": "publication", "iuid": "a3c83a5854494d38acd58145a9a305c6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3c83a5854494d38acd58145a9a305c6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3c83a5854494d38acd58145a9a305c6"}}, "title": "Written Emotional Disclosure Can Promote Athletes' Mental Health and Performance Readiness During the COVID-19 Pandemic.", "authors": [{"family": "Davis", "given": "Paul A", "initials": "PA"}, {"family": "Gustafsson", "given": "Henrik", "initials": "H"}, {"family": "Callow", "given": "Nichola", "initials": "N"}, {"family": "Woodman", "given": "Tim", "initials": "T"}], "type": "journal article", "published": "2020-11-27", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "11", "issue": null, "pages": "599925", "issn-l": "1664-1078"}, "abstract": "The widespread effects of the coronavirus disease 2019 (COVID-19) pandemic have negatively impacted upon many athletes' mental health and increased reports of depression as well as symptoms of anxiety. Disruptions to training and competition schedules can induce athletes' emotional distress, while concomitant government-imposed restrictions (e.g., social isolation, quarantines) reduce the availability of athletes' social and emotional support. Written Emotional Disclosure (WED) has been used extensively in a variety of settings with diverse populations as a means to promote emotional processing. The expressive writing protocol has been used to a limited extent in the context of sport and predominantly in support of athletes' emotional processing during injury rehabilitation. We propose that WED offers an evidence-based treatment that can promote athletes' mental health and support their return to competition. Research exploring the efficacy of the expressive writing protocol highlights a number of theoretical models underpinning the positive effects of WED; we outline how each of these potential mechanisms can address the multidimensional complexity of the challenging circumstances arising from the COVID-19 pandemic (e.g., loss of earnings, returning to training and competition). Considerations and strategies for using WED to support athletes during the COVID-19 pandemic are presented.", "doi": "10.3389/fpsyg.2020.599925", "pmid": "33329269", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7728796"}], "notes": [], "created": "2020-12-21T09:03:40.504Z", "modified": "2021-01-10T18:12:49.509Z"}, {"entity": "publication", "iuid": "f2778adcd2b944c7983e61fdd7315dbf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f2778adcd2b944c7983e61fdd7315dbf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f2778adcd2b944c7983e61fdd7315dbf"}}, "title": "Mental health of Urban Mothers (MUM) study: a multicentre randomised controlled trial, study protocol.", "authors": [{"family": "Schwank", "given": "Simone Eliane", "initials": "SE"}, {"family": "Chung", "given": "Ho-Fung", "initials": "H"}, {"family": "Hsu", "given": "Mandy", "initials": "M"}, {"family": "Fu", "given": "Shih-Chien", "initials": "S"}, {"family": "Du", "given": "Li", "initials": "L"}, {"family": "Zhu", "given": "Liping", "initials": "L"}, {"family": "Huang", "given": "Hsuan-Ying", "initials": "H"}, {"family": "Andersson", "given": "Ewa", "initials": "E"}, {"family": "Acharya", "given": "Ganesh", "initials": "G"}], "type": "journal article", "published": "2020-11-27", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "10", "issue": "11", "pages": "e041133"}, "abstract": "Mental health disorders are common during pregnancy and the postnatal period and can have serious adverse effects on women and their children. The consequences for global mental health due to COVID-19 are likely to be significant and may have a long-term impact on the global burden of disease. Besides physical vulnerability, pregnant women are at increased risk of mental health problems such as anxiety, depression and post-traumatic stress disorder due to the consequences of social distancing. It can result in altered healthcare routines, less support from the family and friends, and in some cases, partners not being allowed to be present during prenatal visits, labour and delivery. Higher than expected, rates of perinatal anxiety and depression have been already reported during the pandemic. Pregnant women may also feel insecure and worried about the effects of COVID-19 on their unborn child if they get infected during pregnancy. Today, young urban women are used to using internet services frequently and efficiently. Therefore, providing mental health support to pregnant women via internet may be effective in ameliorating their anxiety/depression, reducing the risk of serious mental health disorders, and lead to improved maternal and perinatal outcomes.\r\n\r\nOur aim is to explore the effectiveness of a web-based psychosocial peer-to-peer support intervention in reducing the risk and severity of perinatal mental health disorders and preventing adverse pregnancy outcomes among pregnant women living in metropolitan urban settings.\r\n\r\nWe plan to conduct a multicentre prospective randomised controlled trial, Mental health of Urban Mothers trial. Pregnant women living in large metropolitan cities will be recruited using internet-based application through non-profit organisations' websites. The women who consent will be randomised to receive a web-based peer-to-peer support intervention or usual care. Data will be analysed to identify the effects of intervention on Edinburgh Postnatal Depression Score and Generalised Anxiety Disorder 7 scores as well as pregnancy outcomes. The impact of COVID-19 pandemic on maternal stress will be assesed using Impact Event Scale-R. Any differences in outcomes between cities will be addressed in subgroup analyses.\r\n\r\nThe study will be conducted according to the principles of Good Clinical Practice and will follow the ethical principles of the Declaration of Helsinki. The study protocol has been approved by the ethical review board of Chinese University of Hong Kong (IRB number 2019-8170) and Shanghai Center for Women's and Children's Health (international review board (IRB) number 2020-F001-12). The results will be disseminated at national and international scientific conferences, published in peer-reviewed medical journals and spread to the public through social media, news outlets and podcasts.\r\n\r\nNCT04363177; Trial sponsor Karolinska Institute, CLINTEC, Stockholm, Sweden.", "doi": "10.1136/bmjopen-2020-041133", "pmid": "33247023", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT04363177"}], "notes": [], "created": "2020-11-30T07:46:40.493Z", "modified": "2021-02-26T08:47:00.311Z"}, {"entity": "publication", "iuid": "8dd348ce456d47c79151aec5347fef0a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8dd348ce456d47c79151aec5347fef0a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8dd348ce456d47c79151aec5347fef0a"}}, "title": "Covid-19: What Sweden taught Scandinavia for the second wave.", "authors": [{"family": "Habib", "given": "Heba", "initials": "H"}], "type": "journal article", "published": "2020-11-27", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "371", "issue": null, "pages": "m4456", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m4456", "pmid": "33246990", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-30T07:45:48.902Z", "modified": "2020-11-30T07:45:48.924Z"}, {"entity": "publication", "iuid": "c9fdf08396a04e9cb5089bc451fd64b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9fdf08396a04e9cb5089bc451fd64b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9fdf08396a04e9cb5089bc451fd64b0"}}, "title": "Deciphering the ins and outs of SARS-CoV-2-specific T cells.", "authors": [{"family": "Perez-Potti", "given": "Andr\u00e9", "initials": "A"}, {"family": "Lange", "given": "Joshua", "initials": "J"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}], "type": "journal article", "published": "2020-11-26", "journal": {"title": "Nat Immunol", "issn": "1529-2916", "issn-l": null, "volume": "22", "issue": "1", "pages": "8-9"}, "abstract": null, "doi": "10.1038/s41590-020-00838-5", "pmid": "33244183", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41590-020-00838-5"}], "notes": [], "created": "2020-12-04T08:40:41.685Z", "modified": "2021-01-25T13:09:05.326Z"}, {"entity": "publication", "iuid": "1267273983384e4a85c6c81599143317", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1267273983384e4a85c6c81599143317.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1267273983384e4a85c6c81599143317"}}, "title": "Could Naturally Occurring Coronaviral Diseases in Animals Serve as Models for COVID-19? A Review Focusing on the Bovine Model.", "authors": [{"family": "Wensman", "given": "Jonas Johansson", "initials": "JJ"}, {"family": "Stokstad", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2020-11-26", "journal": {"title": "Pathogens", "issn": "2076-0817", "volume": "9", "issue": "12", "issn-l": "2076-0817"}, "abstract": "The current pandemic of COVID-19 has highlighted the importance of basic studies on coronaviruses (CoVs) in general, and severe acute respiratory syndrome CoV type 2 (SARS-CoV-2) in particular. CoVs have for long been studied in veterinary medicine, due to their impact on animal health and welfare, production, and economy. Several animal models using coronaviral disease in the natural host have been suggested. In this review, different animal models are discussed, with the main focus on bovine CoV (BCoV). BCoV is endemic in the cattle population worldwide and has been known and studied for several decades. SARS-CoV-2 and BCoV are both betacoronaviruses, where BCoV is highly similar to human coronavirus (HCoV) OC43, encompassing the same virus species ( Betacoronavirus 1). BCoV causes respiratory and gastrointestinal disease in young and adult cattle. This review summarizes the current knowledge of the similarities and dissimilarities between BCoV and SARS-CoV-2, as well as discussing the usage of BCoV as a model for human CoVs, including SARS-CoV-2.", "doi": "10.3390/pathogens9120991", "pmid": "33256111", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "pathogens9120991"}], "notes": [], "created": "2020-12-03T08:19:17.049Z", "modified": "2020-12-03T08:19:17.059Z"}, {"entity": "publication", "iuid": "3210460c33c34c7ea185651a27581b00", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3210460c33c34c7ea185651a27581b00.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3210460c33c34c7ea185651a27581b00"}}, "title": "Controlling the Outbreak of COVID-19: A Noncooperative Game Perspective.", "authors": [{"family": "Bairagi", "given": "Anupam Kumar", "initials": "AK"}, {"family": "Masud", "given": "Mehedi", "initials": "M"}, {"family": "Kim", "given": "Do Hyeon", "initials": "DH"}, {"family": "Munir", "given": "Md Shirajum", "initials": "MS"}, {"family": "Nahid", "given": "Abdullah-Al", "initials": "AA"}, {"family": "Abedin", "given": "Sarder Fakhrul", "initials": "SF"}, {"family": "Alam", "given": "Kazi Masudul", "initials": "KM"}, {"family": "Biswas", "given": "Sujit", "initials": "S"}, {"family": "Alshamrani", "given": "Sultan S", "initials": "SS"}, {"family": "Han", "given": "Zhu", "initials": "Z"}, {"family": "Hong", "given": "Choong Seon", "initials": "CS"}], "type": "journal article", "published": "2020-11-26", "journal": {"title": "IEEE Access", "issn": "2169-3536", "volume": "8", "pages": "215570-215581", "issn-l": null}, "abstract": "COVID-19 is a global epidemic. Till now, there is no remedy for this epidemic. However, isolation and social distancing are seemed to be effective preventive measures to control this pandemic. Therefore, in this article, an optimization problem is formulated that accommodates both isolation and social distancing features of the individuals. To promote social distancing, we solve the formulated problem by applying a noncooperative game that can provide an incentive for maintaining social distancing to prevent the spread of COVID-19. Furthermore, the sustainability of the lockdown policy is interpreted with the help of our proposed game-theoretic incentive model for maintaining social distancing where there exists a Nash equilibrium. Finally, we perform an extensive numerical analysis that shows the effectiveness of the proposed approach in terms of achieving the desired social-distancing to prevent the outbreak of the COVID-19 in a noncooperative environment. Numerical results show that the individual incentive increases more than 85% with an increasing percentage of home isolation from 25% to 100% for all considered scenarios. The numerical results also demonstrate that in a particular percentage of home isolation, the individual incentive decreases with an increasing number of individuals.", "doi": "10.1109/ACCESS.2020.3040821", "pmid": "34812371", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8545264"}], "notes": [], "created": "2021-11-26T13:23:59.524Z", "modified": "2021-12-10T18:00:17.736Z"}, {"entity": "publication", "iuid": "b8f7c179d4c84272b7105c32a99b99ec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8f7c179d4c84272b7105c32a99b99ec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8f7c179d4c84272b7105c32a99b99ec"}}, "title": "Beginning of the Pandemic: COVID-19-Elicited Anxiety as a Predictor of Working Memory Performance.", "authors": [{"family": "Fellman", "given": "Daniel", "initials": "D"}, {"family": "Ritakallio", "given": "Liisa", "initials": "L"}, {"family": "Waris", "given": "Otto", "initials": "O"}, {"family": "Jylkk\u00e4", "given": "Jussi", "initials": "J"}, {"family": "Laine", "given": "Matti", "initials": "M"}], "type": "journal article", "published": "2020-11-26", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "11", "issue": null, "pages": "576466"}, "abstract": "Increasing evidence indicates that the coronavirus disease 2019 (COVID-19) pandemic is associated with adverse psychological effects, including heightened levels of anxiety. This study examined whether COVID-19-related anxiety levels during the early stage of the pandemic predicted demanding working memory (WM) updating performance. Altogether, 201 healthy adults (age range, 18-50) mostly from North America and the British Isles were recruited to this study via the crowdsourcing site www.prolific.co. The results showed that higher levels of COVID-19-related anxiety during the first weeks of the pandemic outbreak were associated with poorer WM performance as measured by the n-back paradigm. Critically, the unique role of COVID-19-related anxiety on WM could not be explained by demographic factors, or other psychological factors such as state and trait anxiety or fluid intelligence. Moreover, across three assessment points spanning 5-6 weeks, COVID-19-related anxiety levels tended to decrease over time. This pattern of results may reflect an initial psychological \"shock wave\" of the pandemic, the cognitive effects of which may linger for some time, albeit the initial anxiety associated with the pandemic would change with habituation and increasing information. Our results contribute to the understanding of cognitive-affective reactions to a major disaster.", "doi": "10.3389/fpsyg.2020.576466", "pmid": "33324288", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7725684"}, {"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-12-21T09:04:37.394Z", "modified": "2021-02-26T08:47:00.173Z"}, {"entity": "publication", "iuid": "d988eec958034f74b9cd5ea1eb00c0be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d988eec958034f74b9cd5ea1eb00c0be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d988eec958034f74b9cd5ea1eb00c0be"}}, "title": "Trading Health for Wealth: The Effect of COVID-19 Response Stringency.", "authors": [{"family": "Cross", "given": "Megan", "initials": "M"}, {"family": "Ng", "given": "Shu-Kay", "initials": "SK"}, {"family": "Scuffham", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2020-11-24", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "17", "issue": "23", "issn-l": null}, "abstract": "International governments' COVID-19 responses must balance human and economic health. Beyond slowing viral transmission, strict lockdowns have severe economic consequences. This work investigated response stringency, quantified by the Oxford COVID-19 Government Response Tracker's Stringency Index, and examined how restrictive interventions affected infection rates and gross domestic product (GDP) in China and OECD countries. Accounting for response timing, China imposed the most stringent restrictions, while Sweden and Japan were the least stringent. Expected GDP declines range from -8% (Japan) to -15.4% (UK). While greater restrictions generally slowed viral transmission, they failed to reach statistical significance and reduced GDP ( p = 0.006). Timing was fundamental: governments who responded to the pandemic faster saw greater reductions in viral transmission (p = 0.013), but worse decreases in GDP (p = 0.044). Thus, response stringency has a greater effect on GDP than infection rates, which are instead affected by the timing of COVID-19 interventions. Attempts to mitigate economic impacts by delaying restrictions or decreasing stringency may buoy GDP in the short term but increase infection rates, the longer-term economic consequences of which are not yet fully understood. As highly restrictive interventions were successful in some but not all countries, decision-makers must consider whether their strategies are appropriate for the country on health and economic grounds.", "doi": "10.3390/ijerph17238725", "pmid": "33255383", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph17238725"}], "notes": [], "created": "2020-12-03T08:18:31.993Z", "modified": "2020-12-03T08:18:32.007Z"}, {"entity": "publication", "iuid": "0512e611adbe4166a1cc2ff5dee38f98", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0512e611adbe4166a1cc2ff5dee38f98.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0512e611adbe4166a1cc2ff5dee38f98"}}, "title": "Social Determinants Predict Outcomes in Data From a Multi-Ethnic Cohort of 20,899 Patients Investigated for COVID-19.", "authors": [{"family": "Lundon", "given": "Dara J", "initials": "DJ"}, {"family": "Mohamed", "given": "Nihal", "initials": "N"}, {"family": "Lantz", "given": "Anna", "initials": "A"}, {"family": "Goltz", "given": "Heather H", "initials": "HH"}, {"family": "Kelly", "given": "Brian D", "initials": "BD"}, {"family": "Tewari", "given": "Ashutosh K", "initials": "AK"}], "type": "journal article", "published": "2020-11-24", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "8", "issue": null, "pages": "571364"}, "abstract": "Importance: The COVID-19 pandemic exploits existing inequalities in social determinants of health (SDOH) in disease burden and access to healthcare. Few studies have examined these emerging disparities using indicators of SDOH. Objective: To evaluate predictors of COVID-19 test positivity, morbidity, and mortality and their implications for inequalities in SDOH and for future policies and health care improvements. Design, Setting, and Participants: A cross sectional analysis was performed on all patients tested for COVID-19 on the basis of symptoms with either a history of travel to at risk regions or close contact with a confirmed case, across the Mount Sinai Health System (MSHS) up until April 26th 2020. Main Outcomes and Measures: Primary outcome was death from COVID-19 and secondary outcomes were test positivity, and morbidity (e.g., hospitalization and intubation caused by COVID-19). Results: Of 20,899 tested patients, 8,928 tested positive, 1,701 were hospitalized, 684 were intubated, and 1,179 died from COVID-19. Age, sex, race/ethnicity, New York City borough (derived from first 3 digits of zip-code), and English as preferred language were significant predictors of test positivity, hospitalization, intubation and COVID-19 mortality following multivariable logistic regression analyses. Conclusions and Relevance: People residing in poorer boroughs were more likely to be burdened by and die from COVID-19. Our results highlight the importance of integrating comprehensive SDOH data into healthcare efforts with at-risk patient populations.", "doi": "10.3389/fpubh.2020.571364", "pmid": "33324596", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7722480"}, {"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-12-21T10:01:18.157Z", "modified": "2021-02-26T08:46:59.802Z"}, {"entity": "publication", "iuid": "4f8deeb9b8fc4cb9ab821eb4ea8fe0e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4f8deeb9b8fc4cb9ab821eb4ea8fe0e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4f8deeb9b8fc4cb9ab821eb4ea8fe0e1"}}, "title": "Low rate of COVID-19 seroconversion in health-care workers at a Department of Infectious Diseases in Sweden during the later phase of the first wave; a prospective longitudinal seroepidemiological study.", "authors": [{"family": "Rashid-Abdi", "given": "Mulki", "initials": "M"}, {"family": "Krifors", "given": "Anders", "initials": "A"}, {"family": "S\u00e4ll\u00e9ber", "given": "Andreas", "initials": "A"}, {"family": "Eriksson", "given": "Jenny", "initials": "J"}, {"family": "M\u00e5nsson", "given": "Emeli", "initials": "E"}], "type": "journal article", "published": "2020-11-24", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "volume": null, "issue": null, "pages": "1-7", "issn-l": "2374-4235"}, "abstract": "Background: Health-care workers are at risk of contracting and transmitting SARS-CoV-2. The aim of this study was to investigate the prevalence of SARS-CoV-2 IgG antibodies and the rate of seroconversion in an environment with high exposure to SARS-CoV-2. Methods: 131 health-care workers at the Department of Infectious Diseases in V\u00e4ster\u00e5s, Sweden, were included in the study. Abbott's SARS-COV-2 IgG immunoassay was used with a signal cut-off ratio of \u22651.4. Every third week from the beginning of May, blood samples were drawn, and the participants completed a questionnaire regarding symptoms consistent with COVID-19 and the result of any SARS-CoV-2 PCR performed since the last sampling occasion. Participants with IgG antibodies against SARS-CoV-2 were re-sampled only on the sixth and last occasion. Results: At the start of the study, 18 (15%) participants had SARS-CoV-2 IgG antibodies. At the end, 25 (19%) of 131 participants were seropositive. One case of asymptomatic infection was detected, and two cases with PCR-confirmed COVID-19 did not develop IgG antibodies. Conclusion: The low rate of seroconversion during the study suggests that it is possible to prevent transmission of SARS-COV-2 in a high-exposure environment. Compliance with adequate infection control guidelines is the likely explanation of our findings.", "doi": "10.1080/23744235.2020.1849787", "pmid": "33232190", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-26T14:15:35.168Z", "modified": "2021-02-26T08:45:48.126Z"}, {"entity": "publication", "iuid": "13bdf06c2df94e9796f3ce40cb2ada46", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13bdf06c2df94e9796f3ce40cb2ada46.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13bdf06c2df94e9796f3ce40cb2ada46"}}, "title": "How to ensure we can track and trace global use of COVID-19 vaccines?", "authors": [{"family": "Vander Stichele", "given": "Robert H", "initials": "RH"}, {"family": "Hay", "given": "Christian", "initials": "C"}, {"family": "Fladvad", "given": "Malin", "initials": "M"}, {"family": "Sturkenboom", "given": "Miriam C J M", "initials": "MCJM"}, {"family": "Chen", "given": "Robert T", "initials": "RT"}], "type": "journal article", "published": "2020-11-24", "journal": {"title": "Vaccine", "issn": "1873-2518", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.vaccine.2020.11.055", "pmid": "33293161", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(20)31508-5"}], "notes": [], "created": "2020-12-10T09:10:46.004Z", "modified": "2020-12-10T09:13:26.443Z"}, {"entity": "publication", "iuid": "aa777d31f46b4cf9948c95629e70bdf4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aa777d31f46b4cf9948c95629e70bdf4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aa777d31f46b4cf9948c95629e70bdf4"}}, "title": "Excess mortality across regions of Europe during the first wave of the COVID-19 pandemic \u2013 impact of the winter holiday travelling and government responses", "authors": [{"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}, {"family": "Mattisson", "given": "Kristoffer", "initials": "K"}, {"family": "Ahlbom", "given": "Anders", "initials": "A"}], "type": "posted-content", "published": "2020-11-24", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.11.24.20237644", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-10T04:20:55.285Z", "modified": "2021-06-10T04:22:34.266Z"}, {"entity": "publication", "iuid": "8d08457dded94192bbd8f026ed52f527", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d08457dded94192bbd8f026ed52f527.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d08457dded94192bbd8f026ed52f527"}}, "title": "At the Epicenter of COVID-19-the Tragic Failure of the Global Supply Chain for Medical Supplies.", "authors": [{"family": "Bhaskar", "given": "Sonu", "initials": "S"}, {"family": "Tan", "given": "Jeremy", "initials": "J"}, {"family": "Bogers", "given": "Marcel L A M", "initials": "MLAM"}, {"family": "Minssen", "given": "Timo", "initials": "T"}, {"family": "Badaruddin", "given": "Hishamuddin", "initials": "H"}, {"family": "Israeli-Korn", "given": "Simon", "initials": "S"}, {"family": "Chesbrough", "given": "Henry", "initials": "H"}], "type": "journal article", "published": "2020-11-24", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "562882", "issn-l": "2296-2565"}, "abstract": "The tragic failure of the global supply chain in the face of the current coronavirus outbreak has caused acute shortages of essential frontline medical devices and personal protective equipment, crushing fear among frontline health workers and causing fundamental concerns about the sustainability of the health system. Much more coordination, integration, and management of global supply chains will be needed to mitigate the impact of the pandemics. This article describes the pressing need to revisit the governance and resilience of the supply chains that amplified the crisis at pandemic scale. We propose a model that profiles critical stockpiles and improves production efficiency through new technologies such as advanced analytics and blockchain. A new governance system that supports intervention by public-health authorities during critical emergencies is central to our recommendation, both in the face of the current crisis and to be better prepared for potential future crises. These reinforcements offer the potential to minimize the compromise of our healthcare workers and health systems due to infection exposure and build capacity toward preparedness and action for a future outbreak.", "doi": "10.3389/fpubh.2020.562882", "pmid": "33335876", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7737425"}], "notes": [], "created": "2020-12-21T08:55:50.003Z", "modified": "2021-01-10T18:09:54.149Z"}, {"entity": "publication", "iuid": "3ac4c61ae4da4f789cec2d9a7448d388", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ac4c61ae4da4f789cec2d9a7448d388.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ac4c61ae4da4f789cec2d9a7448d388"}}, "title": "S\u00e5 har Sveriges coronastrategi framst\u00e5tt under \u00e5tta m\u00e5nader", "authors": [{"family": "F Ludvigsson", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2020-11-23", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": null, "doi": null, "pmid": "33230806", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "20188"}], "notes": [], "created": "2021-02-10T18:54:12.954Z", "modified": "2021-10-14T09:45:18.560Z"}, {"entity": "publication", "iuid": "9b858f8b0cb944f5ad94af6fda6c93b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b858f8b0cb944f5ad94af6fda6c93b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b858f8b0cb944f5ad94af6fda6c93b9"}}, "title": "Pore-Scale Transport and Two-Phase Fluid Structures in Fibrous Porous Layers: Application to Fuel Cells and Beyond.", "authors": [{"family": "Farzaneh", "given": "Meisam", "initials": "M"}, {"family": "Str\u00f6m", "given": "Henrik", "initials": "H"}, {"family": "Zanini", "given": "Filippo", "initials": "F"}, {"family": "Carmignato", "given": "Simone", "initials": "S"}, {"family": "Sasic", "given": "Srdjan", "initials": "S"}, {"family": "Maggiolo", "given": "Dario", "initials": "D"}], "type": "journal article", "published": "2020-11-23", "journal": {"title": "Transp Porous Media", "issn": "0169-3913", "volume": null, "issue": null, "pages": "1-26", "issn-l": null}, "abstract": "We present pore-scale simulations of two-phase flows in a reconstructed fibrous porous layer. The three-dimensional microstructure of the material, a fuel cell gas diffusion layer, is acquired via X-ray computed tomography and used as input for lattice Boltzmann simulations. We perform a quantitative analysis of the multiphase pore-scale dynamics, and we identify the dominant fluid structures governing mass transport. The results show the existence of three different regimes of transport: a fast inertial dynamics at short times, characterised by a compact uniform front, a viscous-capillary regime at intermediate times, where liquid is transported along a gradually increasing number of preferential flow paths of the size of one-two pores, and a third regime at longer times, where liquid, after having reached the outlet, is exclusively flowing along such flow paths and the two-phase fluid structures are stabilised. We observe that the fibrous layer presents significant variations in its microscopic morphology, which have an important effect on the pore invasion dynamics, and counteract the stabilising viscous force. Liquid transport is indeed affected by the presence of microstructure-induced capillary pressures acting adversely to the flow, leading to capillary fingering transport mechanism and unstable front displacement, even in the absence of hydrophobic treatments of the porous material. We propose a macroscopic model based on an effective contact angle that mimics the effects of the such a dynamic capillary pressure. Finally, we underline the significance of the results for the optimal design of face masks in an effort to mitigate the current COVID-19 pandemic.", "doi": "10.1007/s11242-020-01509-7", "pmid": "33250547", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "1509"}, {"db": "pmc", "key": "PMC7682777"}], "notes": [], "created": "2020-12-03T08:26:27.558Z", "modified": "2021-02-26T08:46:13.387Z"}, {"entity": "publication", "iuid": "5e0aca6899a0474ca133d3d6a9e52ec6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e0aca6899a0474ca133d3d6a9e52ec6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e0aca6899a0474ca133d3d6a9e52ec6"}}, "title": "Low prevalence of bloodstream infection and high blood culture contamination rates in patients with COVID-19.", "authors": [{"family": "Yu", "given": "David", "initials": "D"}, {"family": "Ininbergs", "given": "Karolina", "initials": "K"}, {"family": "Hedman", "given": "Karolina", "initials": "K"}, {"family": "Giske", "given": "Christian G", "initials": "CG"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "\u00d6zenci", "given": "Volkan", "initials": "V"}], "type": "journal article", "published": "2020-11-23", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "15", "issue": "11", "pages": "e0242533", "issn-l": "1932-6203"}, "abstract": "In the management of COVID-19, knowledge is lacking on the frequency of secondary bacterial infections and on how empirical antibiotic therapy should be used. In the present study, we aimed to compare blood culture (BC) results of a COVID-19 patient cohort with two cohorts of patients without detected COVID-19.\n\nUsing a retrospective cohort study design of patients subjected to BC in six tertiary care hospitals, SARS-CoV-2 positive patients from March 1 to April 30 in 2020 (COVID-19 group) were compared to patients without confirmed SARS-CoV-2 during the same period (control group-2020) and with patients sampled March 1 to April 30 in 2019 (control group-2019). The outcomes studied were proportion of BC positivity, clinically relevant growth, and contaminant growth.\n\nIn total 15,103 patients and 17,865 BC episodes were studied. Clinically relevant growth was detected in 197/3,027 (6.5%) BC episodes in the COVID-19 group compared to 717/6,663 (10.8%) in control group-2020 (p<0.0001) and 850/8,175 (10.4%) in control group-2019 (p<0.0001). Contamination was present in 255/3,027 (8.4%) BC episodes in the COVID-19 group compared to 330/6,663 (5.0%) in control group-2020 (p<0.0001) and 354/8,175 (4.3%) in control group-2019 (p<0.0001).\n\nIn COVID-19 patients, the prevalence of bloodstream bacterial infection is low and the contamination rate of BC is high. This knowledge should influence guidelines regarding blood culture sampling and empirical antibiotic therapy in COVID-19 patients.", "doi": "10.1371/journal.pone.0242533", "pmid": "33226995", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-20448"}], "notes": [], "created": "2020-11-26T14:17:26.847Z", "modified": "2021-02-26T08:45:48.234Z"}, {"entity": "publication", "iuid": "4c160f784d3e4ff1a016fabefbe69555", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4c160f784d3e4ff1a016fabefbe69555.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4c160f784d3e4ff1a016fabefbe69555"}}, "title": "Dosing of thromboprophylaxis and mortality in critically ill COVID-19 patients.", "authors": [{"family": "Jonmarker", "given": "Sandra", "initials": "S"}, {"family": "Hollenberg", "given": "Jacob", "initials": "J"}, {"family": "Dahlberg", "given": "Martin", "initials": "M"}, {"family": "Stackelberg", "given": "Otto", "initials": "O"}, {"family": "Litorell", "given": "Jacob", "initials": "J"}, {"family": "Everhov", "given": "\u00c5sa H", "initials": "\u00c5H"}, {"family": "J\u00e4rnbert-Pettersson", "given": "Hans", "initials": "H"}, {"family": "S\u00f6derberg", "given": "M\u00e5rten", "initials": "M"}, {"family": "Grip", "given": "Jonathan", "initials": "J"}, {"family": "Schandl", "given": "Anna", "initials": "A"}, {"family": "G\u00fcnther", "given": "Mattias", "initials": "M"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2020-11-23", "journal": {"title": "Crit Care", "issn": "1466-609X", "issn-l": "1364-8535", "volume": "24", "issue": "1", "pages": "653"}, "abstract": "A substantial proportion of critically ill COVID-19 patients develop thromboembolic complications, but it is unclear whether higher doses of thromboprophylaxis are associated with lower mortality rates. The purpose of the study was to evaluate the association between initial dosing strategy of thromboprophylaxis in critically ill COVID-19 patients and the risk of death, thromboembolism, and bleeding.\r\n\r\nIn this retrospective study, all critically ill COVID-19 patients admitted to two intensive care units in March and April 2020 were eligible. Patients were categorized into three groups according to initial daily dose of thromboprophylaxis: low (2500-4500 IU tinzaparin or 2500-5000 IU dalteparin), medium (> 4500 IU but < 175 IU/kilogram, kg, of body weight tinzaparin or > 5000 IU but < 200 IU/kg of body weight dalteparin), and high dose (\u2265 175 IU/kg of body weight tinzaparin or \u2265 200 IU/kg of body weight dalteparin). Thromboprophylaxis dosage was based on local standardized recommendations, not on degree of critical illness or risk of thrombosis. Cox proportional hazards regression was used to estimate hazard ratios with corresponding 95% confidence intervals of death within 28 days from ICU admission. Multivariable models were adjusted for sex, age, body mass index, Simplified Acute Physiology Score III, invasive respiratory support, and initial dosing strategy of thromboprophylaxis.\r\n\r\nA total of 152 patients were included: 67 received low-, 48 medium-, and 37 high-dose thromboprophylaxis. Baseline characteristics did not differ between groups. For patients who received high-dose prophylaxis, mortality was lower (13.5%) compared to those who received medium dose (25.0%) or low dose (38.8%), p = 0.02. The hazard ratio of death was 0.33 (95% confidence intervals 0.13-0.87) among those who received high dose, and 0.88 (95% confidence intervals 0.43-1.83) among those who received medium dose, as compared to those who received low-dose thromboprophylaxis. There were fewer thromboembolic events in the high (2.7%) vs medium (18.8%) and low-dose thromboprophylaxis (17.9%) groups, p = 0.04.\r\n\r\nAmong critically ill COVID-19 patients with respiratory failure, high-dose thromboprophylaxis was associated with a lower risk of death and a lower cumulative incidence of thromboembolic events compared with lower doses.\r\n\r\nClinicaltrials.gov NCT04412304 June 2, 2020, retrospectively registered.", "doi": "10.1186/s13054-020-03375-7", "pmid": "33225952", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-020-03375-7"}, {"db": "pmc", "key": "PMC7680989"}, {"db": "ClinicalTrials.gov", "key": "NCT04412304"}, {"db": "NA", "key": "Available on request due to privacy restrictions", "description": null}], "notes": [], "created": "2020-11-27T10:54:43.450Z", "modified": "2021-02-26T08:45:48.116Z"}, {"entity": "publication", "iuid": "27ca9b35839c4183a6c84f3ec717d99b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27ca9b35839c4183a6c84f3ec717d99b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27ca9b35839c4183a6c84f3ec717d99b"}}, "title": "Erratum to: COVID-19 healthcare demand and mortality in Sweden in response to non-pharmaceutical mitigation and suppression scenarios.", "authors": [{"family": "Sj\u00f6din", "given": "Henrik", "initials": "H"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}, {"family": "Br\u00e4nnstr\u00f6m", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Farooq", "given": "Zia", "initials": "Z"}, {"family": "Kriit", "given": "Hedi Katre", "initials": "HK"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "\u00c5str\u00f6m", "given": "Christofer", "initials": "C"}, {"family": "Thunberg", "given": "Johan", "initials": "J"}, {"family": "S\u00f6derquist", "given": "M\u00e5rten", "initials": "M"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}], "type": "journal article", "published": "2020-11-22", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "volume": null, "issue": null, "issn-l": "0300-5771"}, "abstract": null, "doi": "10.1093/ije/dyaa234", "pmid": "33221845", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5998420"}], "notes": [], "created": "2020-11-27T10:31:07.914Z", "modified": "2020-11-27T10:31:07.934Z"}, {"entity": "publication", "iuid": "2daf9c0238394a92be440a72221722f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2daf9c0238394a92be440a72221722f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2daf9c0238394a92be440a72221722f8"}}, "title": "Association between Renin-Angiotensin-Aldosterone system inhibitor use and COVID-19 Hospitalization and death: A 1,4 million patient Nation-Wide registry analysis.", "authors": [{"family": "Savarese", "given": "Gianluigi", "initials": "G"}, {"family": "Benson", "given": "Lina", "initials": "L"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Lund", "given": "Lars H", "initials": "LH"}], "type": "journal article", "published": "2020-11-22", "journal": {"title": "Eur J Heart Fail", "issn": "1879-0844", "issn-l": "1388-9842", "volume": null, "issue": null, "pages": null}, "abstract": "Renin-angiotensin-aldosterone-system inhibitors (RAASi) improve outcomes in cardiorenal disease but concerns have been raised over increased risk of incident and death from Covid-19. We investigated the association between use of angiotensin converting enzyme inhibitors (ACEi), angiotensin receptor blockers (ARB) or mineralocorticoid receptor antagonists (MRA) and Covid-19 hospitalization/death in a large nationwide population.\r\n\r\nPatients with hypertension, heart failure, diabetes, kidney disease, or ischemic heart disease registered in the Swedish National Patient Registry until February 1 st 2020 were included and followed until May 31st 2020. Covid-19 cases were defined based on hospitalization/death for Covid-19. Multivariable logistic and Cox regressions were fitted to investigate the association between ACEi/ARB and MRA and risk of hospitalization/death for Covid-19 in the overall population, and of all-cause mortality in Covid-19 cases. We performed consistency analysis to quantify the impact of potential unmeasured confounding. Of 1,387,746 patients (60% receiving ACEi/ARB and 5.8% MRA) 7,146 (0.51%) had incident hospitalization/death from Covid-19. After adjustment for 45 variables, ACEi/ARB use was associated with a reduced risk of hospitalization/death for Covid-19 (Odds Ratio [95% Confidence Interval]: 0.86[0.81-0.91]) in the overall population, and with reduced mortality in Covid-19 cases (Hazard Ratio: 0.89[0.82-0.96]). MRA use was not associated with risk of any outcome. Consistency analysis showed that unmeasured confounding would need to be large for there to be harmful signals associated with RAASi use.\r\n\r\nIn a 1.4 million nation-wide cohort, use of RAASi was not associated with increased risk of hospitalization for or death from Covid-19.", "doi": "10.1002/ejhf.2060", "pmid": "33222412", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Public Health": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [], "notes": [], "created": "2020-11-26T14:25:37.655Z", "modified": "2021-04-28T17:56:44.773Z"}, {"entity": "publication", "iuid": "8546463631214e17b48ae9f1fd895681", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8546463631214e17b48ae9f1fd895681.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8546463631214e17b48ae9f1fd895681"}}, "title": "Type I interferons promote germinal centers through B cell intrinsic signaling and dendritic cell dependent Th1 and Tfh cell lineages", "authors": [{"family": "Dahlgren", "given": "Madelene W", "initials": "MW"}, {"family": "Plumb", "given": "Adam W", "initials": "AW"}, {"family": "Niss", "given": "Kristoffer", "initials": "K"}, {"family": "Lahl", "given": "Katharina", "initials": "K"}, {"family": "Brunak", "given": "S\u00f8ren", "initials": "S"}, {"family": "Johansson-Lindbom", "given": "Bengt", "initials": "B"}], "type": "posted-content", "published": "2020-11-21", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.11.20.390625", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-01-15T16:17:24.701Z", "modified": "2021-07-14T07:52:57.666Z"}, {"entity": "publication", "iuid": "3a3a0fa4e51e4effa15fcd47a46ae482", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a3a0fa4e51e4effa15fcd47a46ae482.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a3a0fa4e51e4effa15fcd47a46ae482"}}, "title": "Modelling the test, trace and quarantine strategy to control the COVID-19 epidemic in the state of S\u00e3o Paulo, Brazil.", "authors": [{"family": "Amaku", "given": "Marcos", "initials": "M"}, {"family": "Covas", "given": "Dimas Tadeu", "initials": "DT"}, {"family": "Bezerra Coutinho", "given": "Francisco Antonio", "initials": "FA"}, {"family": "Azevedo Neto", "given": "Raymundo Soares", "initials": "RS"}, {"family": "Struchiner", "given": "Claudio", "initials": "C"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Massad", "given": "Eduardo", "initials": "E"}], "type": "journal article", "published": "2020-11-20", "journal": {"title": "Infect Dis Model", "issn": "2468-0427", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Testing for detecting the infection by SARS-CoV-2 is the bridge between the lockdown and the opening of society. In this paper we modelled and simulated a test-trace-and-quarantine strategy to control the COVID-19 outbreak in the State of S\u00e3o Paulo, Brasil. The State of S\u00e3o Paulo failed to adopt an effective social distancing strategy, reaching at most 59% in late March and started to relax the measures in late June, dropping to 41% in 08 August. Therefore, S\u00e3o Paulo relies heavily on a massive testing strategy in the attempt to control the epidemic. Two alternative strategies combined with economic evaluations were simulated. One strategy included indiscriminately testing the entire population of the State, reaching more than 40 million people at a maximum cost of 2.25 billion USD, that would reduce the total number of cases by the end of 2020 by 90%. The second strategy investigated testing only symptomatic cases and their immediate contacts - this strategy reached a maximum cost of 150 million USD but also reduced the number of cases by 90%. The conclusion is that if the State of S\u00e3o Paulo had decided to adopt the simulated strategy on April the 1st, it would have been possible to reduce the total number of cases by 90% at a cost of 2.25 billion US dollars for the indiscriminate strategy but at a much smaller cost of 125 million US dollars for the selective testing of symptomatic cases and their contacts.", "doi": "10.1016/j.idm.2020.11.004", "pmid": "33235942", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S2468-0427(20)30074-9"}, {"db": "pmc", "key": "PMC7677040"}], "notes": [], "created": "2020-11-27T10:28:12.415Z", "modified": "2022-11-09T08:16:52.712Z"}, {"entity": "publication", "iuid": "5dccf7ce244346c0924ee31e6852684c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5dccf7ce244346c0924ee31e6852684c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5dccf7ce244346c0924ee31e6852684c"}}, "title": "Effect of COVID-19 on maternal and neonatal services - Authors' reply.", "authors": [{"family": "Kc", "given": "Ashish", "initials": "A"}, {"family": "Kinney", "given": "Mary V", "initials": "MV"}, {"family": "Lawn", "given": "Joy E", "initials": "JE"}], "type": "letter", "published": "2020-11-20", "journal": {"title": "Lancet Glob Health", "issn": "2214-109X", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/S2214-109X(20)30486-1", "pmid": "33227257", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2214-109X(20)30486-1"}], "notes": [], "created": "2020-11-27T10:29:07.591Z", "modified": "2020-11-27T10:29:07.611Z"}, {"entity": "publication", "iuid": "20fd08edee8f451198a5e24ea3f85ab0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/20fd08edee8f451198a5e24ea3f85ab0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/20fd08edee8f451198a5e24ea3f85ab0"}}, "title": "Economic arguments in migrant health policymaking: proposing a research agenda.", "authors": [{"family": "Gottlieb", "given": "Nora", "initials": "N"}, {"family": "Trummer", "given": "Ursula", "initials": "U"}, {"family": "Davidovitch", "given": "Nadav", "initials": "N"}, {"family": "Krasnik", "given": "Allan", "initials": "A"}, {"family": "Ju\u00e1rez", "given": "Sol P", "initials": "SP"}, {"family": "Rostila", "given": "Mikael", "initials": "M"}, {"family": "Biddle", "given": "Louise", "initials": "L"}, {"family": "Bozorgmehr", "given": "Kayvan", "initials": "K"}], "type": "letter", "published": "2020-11-20", "journal": {"title": "Global Health", "issn": "1744-8603", "volume": "16", "issue": "1", "pages": "113", "issn-l": "1744-8603"}, "abstract": "Welfare states around the world restrict access to public healthcare for some migrant groups. Formal restrictions on migrants' healthcare access are often justified with economic arguments; for example, as a means to prevent excess costs and safeguard scarce resources. However, existing studies on the economics of migrant health policies suggest that restrictive policies increase rather than decrease costs. This evidence has largely been ignored in migration debates. Amplifying the relationship between welfare state transformations and the production of inequalities, the Covid-19 pandemic may fuel exclusionary rhetoric and politics; or it may serve as an impetus to reconsider the costs that one group's exclusion from health can entail for all members of society.The public health community has a responsibility to promote evidence-informed health policies that are ethically and economically sound, and to counter anti-migrant and racial discrimination (whether overt or masked with economic reasoning). Toward this end, we propose a research agenda which includes 1) the generation of a comprehensive body of evidence on economic aspects of migrant health policies, 2) the clarification of the role of economic arguments in migration debates, 3) (self-)critical reflection on the ethics and politics of the production of economic evidence, 4) the introduction of evidence into migrant health policymaking processes, and 5) the endorsement of inter- and transdisciplinary approaches. With the Covid-19 pandemic and surrounding events rendering the suggested research agenda more topical than ever, we invite individuals and groups to join forces toward a (self-)critical examination of economic arguments in migration and health, and in public health generally.", "doi": "10.1186/s12992-020-00642-8", "pmid": "33218359", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12992-020-00642-8"}, {"db": "pmc", "key": "PMC7677743"}], "notes": [], "created": "2020-11-26T14:30:47.278Z", "modified": "2020-11-27T10:31:53.618Z"}, {"entity": "publication", "iuid": "b738ecb0902748d2b2458b462fd883cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b738ecb0902748d2b2458b462fd883cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b738ecb0902748d2b2458b462fd883cc"}}, "title": "The COVID-19 pandemic and global environmental change: Emerging research needs.", "authors": [{"family": "Barouki", "given": "Robert", "initials": "R"}, {"family": "Kogevinas", "given": "Manolis", "initials": "M"}, {"family": "Audouze", "given": "Karine", "initials": "K"}, {"family": "Belesova", "given": "Kristine", "initials": "K"}, {"family": "Bergman", "given": "Ake", "initials": "A"}, {"family": "Birnbaum", "given": "Linda", "initials": "L"}, {"family": "Boekhold", "given": "Sandra", "initials": "S"}, {"family": "Denys", "given": "Sebastien", "initials": "S"}, {"family": "Desseille", "given": "Celine", "initials": "C"}, {"family": "Drakvik", "given": "Elina", "initials": "E"}, {"family": "Frumkin", "given": "Howard", "initials": "H"}, {"family": "Garric", "given": "Jeanne", "initials": "J"}, {"family": "Destoumieux-Garzon", "given": "Delphine", "initials": "D"}, {"family": "Haines", "given": "Andrew", "initials": "A"}, {"family": "Huss", "given": "Anke", "initials": "A"}, {"family": "Jensen", "given": "Genon", "initials": "G"}, {"family": "Karakitsios", "given": "Spyros", "initials": "S"}, {"family": "Klanova", "given": "Jana", "initials": "J"}, {"family": "Koskela", "given": "Iida-Maria", "initials": "IM"}, {"family": "Laden", "given": "Francine", "initials": "F"}, {"family": "Marano", "given": "Francelyne", "initials": "F"}, {"family": "Franziska Matthies-Wiesler", "given": "Eva", "initials": "E"}, {"family": "Morris", "given": "George", "initials": "G"}, {"family": "Nowacki", "given": "Julia", "initials": "J"}, {"family": "Paloniemi", "given": "Riikka", "initials": "R"}, {"family": "Pearce", "given": "Neil", "initials": "N"}, {"family": "Peters", "given": "Annette", "initials": "A"}, {"family": "Rekola", "given": "Aino", "initials": "A"}, {"family": "Sarigiannis", "given": "Denis", "initials": "D"}, {"family": "\u0160ebkov\u00e1", "given": "Katerina", "initials": "K"}, {"family": "Slama", "given": "Remy", "initials": "R"}, {"family": "Staatsen", "given": "Brigit", "initials": "B"}, {"family": "Tonne", "given": "Cathryn", "initials": "C"}, {"family": "Vermeulen", "given": "Roel", "initials": "R"}, {"family": "Vineis", "given": "Paolo", "initials": "P"}, {"family": "HERA-COVID-19 working group. Electronic address: https://www.heraresearcheu.eu/", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-19", "journal": {"title": "Environ Int", "issn": "1873-6750", "volume": "146", "issue": null, "pages": "106272", "issn-l": "0160-4120"}, "abstract": "The outbreak of COVID-19 raised numerous questions on the interactions between the occurrence of new infections, the environment, climate and health. The European Union requested the H2020 HERA project which aims at setting priorities in research on environment, climate and health, to identify relevant research needs regarding Covid-19. The emergence and spread of SARS-CoV-2 appears to be related to urbanization, habitat destruction, live animal trade, intensive livestock farming and global travel. The contribution of climate and air pollution requires additional studies. Importantly, the severity of COVID-19 depends on the interactions between the viral infection, ageing and chronic diseases such as metabolic, respiratory and cardiovascular diseases and obesity which are themselves influenced by environmental stressors. The mechanisms of these interactions deserve additional scrutiny. Both the pandemic and the social response to the disease have elicited an array of behavioural and societal changes that may remain long after the pandemic and that may have long term health effects including on mental health. Recovery plans are currently being discussed or implemented and the environmental and health impacts of those plans are not clearly foreseen. Clearly, COVID-19 will have a long-lasting impact on the environmental health field and will open new research perspectives and policy needs.", "doi": "10.1016/j.envint.2020.106272", "pmid": "33238229", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0160-4120(20)32227-3"}, {"db": "pmc", "key": "PMC7674147"}], "notes": [], "created": "2020-11-27T10:27:55.912Z", "modified": "2020-11-30T07:44:55.359Z"}, {"entity": "publication", "iuid": "427a5f1f5bfb4a65a0ee29d88d1e1242", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/427a5f1f5bfb4a65a0ee29d88d1e1242.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/427a5f1f5bfb4a65a0ee29d88d1e1242"}}, "title": "Synthesis of Recommendations From 25 Countries and 31 Oncology Societies: How to Navigate Through Covid-19 Labyrinth.", "authors": [{"family": "Kamposioras", "given": "Konstantinos", "initials": "K"}, {"family": "Mauri", "given": "Davide", "initials": "D"}, {"family": "Papadimitriou", "given": "Konstantinos", "initials": "K"}, {"family": "Anthoney", "given": "Alan", "initials": "A"}, {"family": "Hindi", "given": "Nadia", "initials": "N"}, {"family": "Petricevic", "given": "Branka", "initials": "B"}, {"family": "Dambrosio", "given": "Mario", "initials": "M"}, {"family": "Valachis", "given": "Antonis", "initials": "A"}, {"family": "Kountourakis", "given": "Pantelis", "initials": "P"}, {"family": "Kopecky", "given": "Jindrich", "initials": "J"}, {"family": "Kuhar", "given": "Cvetka Gra\u0161i\u010d", "initials": "CG"}, {"family": "Popovic", "given": "Lazar", "initials": "L"}, {"family": "Chilingirova", "given": "Nataliya P", "initials": "NP"}, {"family": "Zarkavelis", "given": "George", "initials": "G"}, {"family": "de Mello", "given": "Ramon Andrade", "initials": "RA"}, {"family": "Plaveti\u0107", "given": "Natalija Dedi\u0107", "initials": "ND"}, {"family": "Christopoulos", "given": "Christos", "initials": "C"}, {"family": "Mostert", "given": "Bianca", "initials": "B"}, {"family": "Goffin", "given": "John R", "initials": "JR"}, {"family": "Tzachanis", "given": "Dimitiros", "initials": "D"}, {"family": "Saraireh", "given": "Haytham Hamed", "initials": "HH"}, {"family": "Ma", "given": "Fei", "initials": "F"}, {"family": "Pavese", "given": "Ida", "initials": "I"}, {"family": "Tolia", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2020-11-19", "journal": {"title": "Front Oncol", "issn": "2234-943X", "volume": "10", "issue": null, "pages": "575148", "issn-l": null}, "abstract": "Pandemic COVID-19 is an unexpected challenge for the oncological community, indicating potential detrimental effects on cancer patients. Our aim was to summarize the converging key points providing a general guidance in order to support decision making, pertaining to the oncologic care in the middle of a global outbreak.\n\nWe did an international online search in twenty five countries that have managed a surge in cancer patient numbers. We collected the recommendations from thirty one medical oncology societies.\n\nBy synthesizing guidelines for a) oncology service delivery adjustments, b) general and specific treatment adaptations, and c) discrepancies from guidelines comparison, we present a clinical synopsis with the forty more crucial statements. A Covid-19 risk stratification base was also created in order to obtain a quick, objective patient assessment and a risk-benefit evaluation on a case-by-case basis.\n\nIn an attempt to face these complex needs and due to limited understanding of COVID-19, a variability of recommendations based on general epidemiological and infectious disease principles rather than definite cancer-related evidence has evolved. Additionally, the absence of an effective treatment or vaccine requires the development of cancer management guidance, capitalizing on comprehensive COVID-19 oncology experience globally.", "doi": "10.3389/fonc.2020.575148", "pmid": "33330049", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7711151"}], "notes": [], "created": "2020-12-21T09:02:31.979Z", "modified": "2021-01-10T18:12:27.920Z"}, {"entity": "publication", "iuid": "edb87ec1c2214788a11083c24eca19c3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/edb87ec1c2214788a11083c24eca19c3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/edb87ec1c2214788a11083c24eca19c3"}}, "title": "Sleep Laboratories Reopening and COVID-19: A European Perspective.", "authors": [{"family": "Schiza", "given": "Sophia", "initials": "S"}, {"family": "Simonds", "given": "Anita", "initials": "A"}, {"family": "Randerath", "given": "Winfried", "initials": "W"}, {"family": "Fanfulla", "given": "Francesco", "initials": "F"}, {"family": "Testelmans", "given": "Dries", "initials": "D"}, {"family": "Grote", "given": "Ludger", "initials": "L"}, {"family": "Montserrat", "given": "Joseph M", "initials": "JM"}, {"family": "Pepin", "given": "Jean-Louis", "initials": "JL"}, {"family": "Verbracken", "given": "Johan", "initials": "J"}, {"family": "Ersu", "given": "Refika", "initials": "R"}, {"family": "Bonsignore", "given": "Maria R", "initials": "MR"}], "type": "journal article", "published": "2020-11-19", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "volume": null, "issue": null, "issn-l": "0903-1936"}, "abstract": "The clinical activities regarding sleep disordered breathing (SDB) have been sharply interrupted during the initial phase of the COVID-19 epidemic throughout Europe. In the last months, activities have gradually restarted, according to epidemiological phase of COVID-19 and National recommendations. The recent increase in cases throughout Europe obliges to reconsider management strategies of SDB accordingly. Diagnosis of SDB and initiation of treatment pose some specific problems to be addressed to preserve safety of the patients and health personnel. This perspective document by a group of European sleep experts aims at summarising some different approaches followed in Europe and United States, which reflect National recommendations according to the epidemiological phase of the COVID-19 infection. Respiratory sleep medicine will likely change in the near future, and use of telemedicine will grow to avoid unnecessary risks and continue to provide optimal care to the patients. The document also covers pediatric sleep studies and indications for titration of noninvasive ventilation, as well as precautions to be followed by patients who are already on positive airway pressure treatment. A single consensus document developed by the European Respiratory Society and National Societies would be desirable to harmonise SDB management throughout Europe.", "doi": "10.1183/13993003.02722-2020", "pmid": "33214202", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "13993003.02722-2020"}, {"db": "pmc", "key": "PMC7683791"}], "notes": [], "created": "2020-11-27T10:43:18.484Z", "modified": "2020-11-27T10:43:18.495Z"}, {"entity": "publication", "iuid": "f3b6d71139b14f2a8521373afff4ffaa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f3b6d71139b14f2a8521373afff4ffaa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f3b6d71139b14f2a8521373afff4ffaa"}}, "title": "Genetically proxied interleukin-6 receptor inhibition: opposing associations with COVID-19 and pneumonia.", "authors": [{"family": "Larsson", "given": "Susanna C", "initials": "SC"}, {"family": "Burgess", "given": "Stephen", "initials": "S"}, {"family": "Gill", "given": "Dipender", "initials": "D"}], "type": "letter", "published": "2020-11-19", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "issn-l": "0903-1936", "volume": "57", "issue": "1", "pages": null}, "abstract": null, "doi": "10.1183/13993003.03545-2020", "pmid": "33214204", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "13993003.03545-2020"}, {"db": "pmc", "key": "PMC7683792"}], "notes": [], "created": "2020-11-26T14:34:25.701Z", "modified": "2021-02-26T08:45:14.513Z"}, {"entity": "publication", "iuid": "1a27e0a50b4d4dfeb5ab4e7e90004286", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1a27e0a50b4d4dfeb5ab4e7e90004286.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1a27e0a50b4d4dfeb5ab4e7e90004286"}}, "title": "Brief Online Cognitive Behavioural Intervention for Dysfunctional Worry Related to the COVID-19 Pandemic: A Randomised Controlled Trial.", "authors": [{"family": "Wahlund", "given": "Tove", "initials": "T"}, {"family": "Mataix-Cols", "given": "David", "initials": "D"}, {"family": "Olofsdotter Lauri", "given": "Klara", "initials": "K"}, {"family": "de Schipper", "given": "Elles", "initials": "E"}, {"family": "Lj\u00f3tsson", "given": "Brj\u00e1nn", "initials": "B"}, {"family": "Aspvall", "given": "Kristina", "initials": "K"}, {"family": "Andersson", "given": "Erik", "initials": "E"}], "type": "journal article", "published": "2020-11-19", "journal": {"title": "Psychother Psychosom", "issn": "1423-0348", "issn-l": "0033-3190", "volume": null, "issue": null, "pages": "1-9"}, "abstract": "Worries about the immediate and long-term consequences of the COVID-19 pandemic may for some individuals develop into pervasive worry that is disproportionate in its intensity or duration and significantly interferes with everyday life.\r\n\r\nThe aim of this study was to investigate if a brief self-guided, online psychological intervention can reduce the degree of dysfunctional worry related to the COVID-19 pandemic and associated symptoms.\r\n\r\n670 adults from the Swedish general population reporting daily uncontrollable worry about CO-VID-19 and its possible consequences (e.g., illness, death, the economy, one's family) were randomised (1:1 ratio) to a 3-week self-guided, online cognitive behavioural intervention targeting dysfunctional COVID-19 worry and associated symptoms, or a waiting list of equal duration. The primary outcome measure was a COVID-19 adapted version of the Generalised Anxiety Disorder 7-item scale administered at baseline and weeks 1-3 (primary endpoint). Follow-up assessments were conducted 1 month after treatment completion. The trial was registered on ClinicalTrials.gov (NCT04341922) before inclusion of the first participant.\r\n\r\nThe main pre-specified intention-to-treat analysis indicated significant reductions in COVID-19-related worry for the intervention group compared to the waiting list (\u03b2 = 1.14, Z = 9.27, p < 0.001), corresponding to a medium effect size (bootstrapped d = 0.74 [95% CI: 0.58-0.90]). Improvements were also seen on all secondary measures, including mood, daily functioning, insomnia, and intolerance of uncertainty. Participant satisfaction was high. No serious adverse events were recorded.\r\n\r\nA brief digital and easily scalable self-guided psychological intervention can significantly reduce dysfunctional worry and associated behavioural symptoms related to the COVID-19 pandemic.", "doi": "10.1159/000512843", "pmid": "33212440", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "000512843"}, {"db": "ClinicalTrials.gov", "key": "NCT04341922"}], "notes": [], "created": "2020-11-27T09:45:47.728Z", "modified": "2021-02-26T08:46:59.845Z"}, {"entity": "publication", "iuid": "8da9a0a08cdf424ab35a2b5c1c3da037", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8da9a0a08cdf424ab35a2b5c1c3da037.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8da9a0a08cdf424ab35a2b5c1c3da037"}}, "title": "The known unknowns of T cell immunity to COVID-19.", "authors": [{"family": "Karlsson", "given": "Annika C", "initials": "AC", "orcid": "0000-0002-2028-8393", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9abf28110888427497db1e4abf6ff71d.json"}}, {"family": "Humbert", "given": "Marion", "initials": "M", "orcid": "0000-0002-1710-1479", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e43ab29ae76344aa83909afff892c6db.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}], "type": "journal article", "published": "2020-11-18", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "issn-l": "2470-9468", "volume": "5", "issue": "53", "pages": null}, "abstract": "Tremendous progress has been made in understanding the role of T cell immunity in acute and convalescent COVID-19 infection. Here we shed light on the \"known unknowns\" of pre-existing and acquired T cell responses in relation to acute and convalescent SARS-CoV-2 infection.", "doi": "10.1126/sciimmunol.abe8063", "pmid": "33208380", "labels": {"Type: Review": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "5/53/eabe8063"}], "notes": [], "created": "2020-11-27T09:49:11.516Z", "modified": "2023-06-19T14:56:20.106Z"}, {"entity": "publication", "iuid": "ab717979c71e46bbb7a827972b7a2835", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ab717979c71e46bbb7a827972b7a2835.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ab717979c71e46bbb7a827972b7a2835"}}, "title": "The impact of early public health interventions on SARS-CoV-2 transmission and evolution", "authors": [{"family": "Duchene", "given": "Sebastian", "initials": "S"}, {"family": "Featherstone", "given": "Leo", "initials": "L"}, {"family": "de Blasio", "given": "Birgitte Freiesleben", "initials": "BF"}, {"family": "Holmes", "given": "Edward C", "initials": "EC"}, {"family": "Bohlin", "given": "Jon", "initials": "J"}, {"family": "Pettersson", "given": "John H O", "initials": "JHO"}], "type": "posted-content", "published": "2020-11-18", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Many countries have attempted to control COVID-19 through the implementation of non-pharmaceutical interventions. However, it remains unclear how different control strategies have impacted SARS-CoV-2 virus transmission dynamics at the local level. Using complete SARS-CoV-2 genomes, we inferred the relative frequencies of virus importation and exportation, as well as virus transmission chain dynamics in Nordic countries - Denmark, Finland, Iceland, Norway and Sweden - during the first months of the pandemic. Our analyses revealed that Sweden experienced more numerous transmission chains, which tended to have more cases, and were of longer duration, a set of features that increased with time. Together with Denmark, Sweden was also a net exporter of SARS-CoV-2. Hence, Sweden effectively constituted an epidemiological and evolutionary \u2018refugia\u2019 that enabled the virus to maintain active transmission and spread to other geographic localities. This analysis highlights the utility of genomic surveillance where active transmission chain monitoring is a key metric.", "doi": "10.1101/2020.11.18.20233767", "pmid": null, "labels": {"Category: Genomics & transcriptomics": null, "Type: Preprint": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://www.medrxiv.org/content/medrxiv/early/2021/07/06/2020.11.18.20233767/DC1/embed/media-1.zip?download=true", "description": "Data available on GISAID, accession numbers found here (in the Supplementary Material)"}], "notes": [], "created": "2021-06-04T12:15:38.051Z", "modified": "2021-11-18T10:30:26.404Z"}, {"entity": "publication", "iuid": "03bef30654104a3da77bdc8ad1380279", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/03bef30654104a3da77bdc8ad1380279.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/03bef30654104a3da77bdc8ad1380279"}}, "title": "Misinformation, chiropractic, and the COVID-19 pandemic.", "authors": [{"family": "Ax\u00e9n", "given": "Iben", "initials": "I"}, {"family": "Bergstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Bronson", "given": "Marc", "initials": "M"}, {"family": "C\u00f4t\u00e9", "given": "Pierre", "initials": "P"}, {"family": "Nim", "given": "Casper Glissmann", "initials": "CG"}, {"family": "Goncalves", "given": "Guillaume", "initials": "G"}, {"family": "H\u00e9bert", "given": "Jeffrey J", "initials": "JJ"}, {"family": "Hertel", "given": "Joakim Axel", "initials": "JA"}, {"family": "Innes", "given": "Stanley", "initials": "S"}, {"family": "Larsen", "given": "Ole Kristoffer", "initials": "OK"}, {"family": "Meyer", "given": "Anne-Laure", "initials": "AL"}, {"family": "O'Neill", "given": "S\u00f8ren", "initials": "S"}, {"family": "Perle", "given": "Stephen M", "initials": "SM"}, {"family": "Weber", "given": "Kenneth A", "initials": "KA"}, {"family": "Young", "given": "Kenneth J", "initials": "KJ"}, {"family": "Leboeuf-Yde", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2020-11-18", "journal": {"title": "Chiropr Man Therap", "issn": "2045-709X", "volume": "28", "issue": "1", "pages": "65", "issn-l": "2045-709X"}, "abstract": "In March 2020, the World Health Organization elevated the coronavirus disease (COVID-19) epidemic to a pandemic and called for urgent and aggressive action worldwide. Public health experts have communicated clear and emphatic strategies to prevent the spread of COVID-19. Hygiene rules and social distancing practices have been implemented by entire populations, including 'stay-at-home' orders in many countries. The long-term health and economic consequences of the COVID-19 pandemic are not yet known.\n\nDuring this time of crisis, some chiropractors made claims on social media that chiropractic treatment can prevent or impact COVID-19. The rationale for these claims is that spinal manipulation can impact the nervous system and thus improve immunity. These beliefs often stem from nineteenth-century chiropractic concepts. We are aware of no clinically relevant scientific evidence to support such statements. We explored the internet and social media to collect examples of misinformation from Europe, North America, Australia and New Zealand regarding the impact of chiropractic treatment on immune function. We discuss the potential harm resulting from these claims and explore the role of chiropractors, teaching institutions, accrediting agencies, and legislative bodies.\n\nMembers of the chiropractic profession share a collective responsibility to act in the best interests of patients and public health. We hope that all chiropractic stakeholders will view the COVID-19 pandemic as a call to action to eliminate the unethical and potentially dangerous claims made by chiropractors who practise outside the boundaries of scientific evidence.", "doi": "10.1186/s12998-020-00353-2", "pmid": "33208144", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12998-020-00353-2"}, {"db": "pmc", "key": "PMC7672412"}], "notes": [], "created": "2020-11-26T12:36:03.161Z", "modified": "2020-11-27T09:51:10.068Z"}, {"entity": "publication", "iuid": "fda32fda6e5f47cd98b64d825f7259cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fda32fda6e5f47cd98b64d825f7259cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fda32fda6e5f47cd98b64d825f7259cb"}}, "title": "CETSA MS Profiling for a Comparative Assessment of FDA-Approved Antivirals Repurposed for COVID-19 Therapy Identifies TRIP13 as a Remdesivir Off-Target.", "authors": [{"family": "Friman", "given": "Tomas", "initials": "T"}, {"family": "Chernobrovkin", "given": "Alexey", "initials": "A"}, {"family": "Martinez Molina", "given": "Daniel", "initials": "D"}, {"family": "Arnold", "given": "Laurence", "initials": "L"}], "type": "journal article", "published": "2020-11-18", "journal": {"title": "SLAS Discov", "issn": "2472-5560", "issn-l": null, "volume": null, "issue": null, "pages": "2472555220973597"}, "abstract": "The reuse of preexisting small molecules for a novel emerging disease threat is a rapid measure to discover unknown applications for previously validated therapies. A pertinent and recent example where such a strategy could be employed is in the fight against coronavirus disease 2019 (COVID-19). Therapies designed or discovered to target viral proteins also have off-target effects on the host proteome when employed in a complex physiological environment. This study aims to assess these host cell targets for a panel of FDA-approved antiviral compounds including remdesivir, using the cellular thermal shift assay (CETSA) coupled with mass spectrometry (CETSA MS) in noninfected cells. CETSA MS is a powerful method to delineate direct and indirect interactions between small molecules and protein targets in intact cells. Biologically active compounds can induce changes in thermal stability, in their primary binding partners, and in proteins that in turn interact with the direct targets. Such engagement of host targets by antiviral drugs may contribute to the clinical effect against the virus but can also constitute a liability. We present here a comparative study of CETSA molecular target engagement fingerprints of antiviral drugs to better understand the link between off-targets and efficacy.", "doi": "10.1177/2472555220973597", "pmid": "33208020", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2020-11-30T16:12:53.941Z", "modified": "2021-02-26T08:45:25.950Z"}, {"entity": "publication", "iuid": "be13b13ee3b04c2288d72970f20ea3a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be13b13ee3b04c2288d72970f20ea3a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be13b13ee3b04c2288d72970f20ea3a2"}}, "title": "The limits of estimating COVID-19 intervention effects using Bayesian models", "authors": [{"family": "Elofsson", "given": "Arne", "initials": "A"}, {"family": "Bryant", "given": "Patrick", "initials": "P"}], "type": "posted-content", "published": "2020-11-17", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To limit the rapid spread of COVID-19, most governments have introduced different non-pharmaceutical interventions, which might have severe costs for society. Therefore, it is crucial to evaluate the most cost-effective interventions, using, for instance, Bayesian modelling. Such modelling efforts have deemed lockdown to account for 81% of the reduction in R0, contributing to government policies. Here, we show that these conclusions are unsupported and that policies therefore should not be based on these studies.", "doi": "10.1101/2020.08.14.20175240", "pmid": null, "labels": {"Funder: VR": null, "Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-17T13:25:54.970Z", "modified": "2021-02-26T08:45:48.630Z"}, {"entity": "publication", "iuid": "a9a372ecfb2043dcbeb9484cacd0b451", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a9a372ecfb2043dcbeb9484cacd0b451.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a9a372ecfb2043dcbeb9484cacd0b451"}}, "title": "The effect of opening up the US on COVID-19 spread", "authors": [{"family": "Elofsson", "given": "Arne", "initials": "A"}, {"family": "Bryant", "given": "Patrick", "initials": "P"}], "type": null, "published": "2020-11-17", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "In response to the pandemic development of the novel coronavirus (SARS-CoV-2), governments worldwide have implemented strategies of suppression by non-pharmaceutical interventions (NPIs). Such NPIs include social distancing, school closures, limiting international travel and complete lockdown. Worldwide the NPIs enforced to limit the spread of COVID-19 are now being lifted. Understanding how the risk increases when NPIs are lifted is important for decision making. Treating NPIs equally across countries and regions limits the possibility for modelling differences in epidemic response, as the response to the NPIs influences can vary between regions and this can affect the epidemic outcome, so do the strength and speed of lifting these. Our solution to this is to measure mobility changes from mobile phone data and their impacts on the basic reproductive number. We model the epidemic in all US states to compare the difference in outcome if NPIs are lifted or retained. We show that keeping NPIs just a few weeks longer has a substantial impact on the epidemic outcome.", "doi": "10.1101/2020.07.03.20145649", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "URL", "key": "https://github.com/patrickbryant1/COVID19.github.io/tree/master/simulations/mobility/dev/US", "description": "Analysis code and data"}], "notes": [], "created": "2020-11-17T13:20:52.223Z", "modified": "2022-11-09T08:20:04.453Z"}, {"entity": "publication", "iuid": "7ca4e69b988a427d86f38d90955b2c7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7ca4e69b988a427d86f38d90955b2c7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7ca4e69b988a427d86f38d90955b2c7e"}}, "title": "Perturbations in the mononuclear phagocyte landscape associated with COVID-19 disease severity", "authors": [{"family": "Kvedaraite", "given": "Egle", "initials": "E"}, {"family": "Hertwig", "given": "Laura", "initials": "L"}, {"family": "Indranil", "given": "Sinha", "initials": "S"}, {"family": "Ponzetta", "given": "Andrea", "initials": "A"}, {"family": "Hed Myrberg", "given": "Ida", "initials": "I"}, {"family": "Magdalini Lourda", "given": "M", "initials": "M"}, {"family": "Dzidic", "given": "Majda", "initials": "M"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Klingstrom", "given": "Jonas", "initials": "J"}, {"family": "Folkesson", "given": "Elin", "initials": "E"}, {"family": "Muvva", "given": "Rao", "initials": "R"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Brighenti", "given": "Susanna", "initials": "S"}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A"}, {"family": "Lars I. Eriksson", "given": "Lars I.", "initials": "LI"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Stralin", "given": "Krustoffer", "initials": "K"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Ginhoux", "given": "Florent", "initials": "F"}, {"family": "Bjorkstrom", "given": "Niclas", "initials": "N"}, {"family": "Henter", "given": "Jan-Inge", "initials": "J"}, {"family": "Svensson", "given": "Mattias", "initials": "M"}], "type": "journal article", "published": "2020-11-17", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "issn-l": "0027-8424", "volume": "118", "issue": "6", "pages": null}, "abstract": "Monocytes and dendritic cells are crucial mediators of innate and adaptive immune responses during viral infection, but misdirected responses by these cells might contribute to immunopathology. A comprehensive map of the mononuclear phagocyte (MNP) landscape during SARS-CoV-2 infection and concomitant COVID-19 disease is lacking. We performed 25-color flow cytometry-analysis focusing on MNP lineages in SARS-CoV-2 infected patients with moderate and severe COVID-19. While redistribution of monocytes towards intermediate subset and decrease in circulating DCs occurred in response to infection, severe disease associated with appearance of Mo-MDSC-like cells and a higher frequency of pre-DC2. Furthermore, phenotypic alterations in MNPs, and their late precursors, were cell-lineage specific and in select cases associated with severe disease. Finally, unsupervised analysis revealed that the MNP profile, alone, could identify a cluster of COVID-19 non-survivors. This study provides a reference for the MNP response to clinical SARS-CoV-2 infection and unravel myeloid dysregulation associated with severe COVID-19.", "doi": "10.1073/pnas.2018587118", "pmid": "33479167", "labels": {"Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null, "Funder: Vinnova": null, "Funder: VR": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-17T17:34:32.059Z", "modified": "2021-06-13T14:15:44.123Z"}, {"entity": "publication", "iuid": "19520c0d2e594922b47369a93ce61cb0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19520c0d2e594922b47369a93ce61cb0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19520c0d2e594922b47369a93ce61cb0"}}, "title": "Outcome prediction by serum calprotectin in patients with COVID-19 in the emergency department.", "authors": [{"family": "Bauer", "given": "Wolfgang", "initials": "W"}, {"family": "Diehl-Wiesenecker", "given": "Eva", "initials": "E"}, {"family": "Ulke", "given": "Jannis", "initials": "J"}, {"family": "Galtung", "given": "Noa", "initials": "N"}, {"family": "Havelka", "given": "Aleksandra", "initials": "A"}, {"family": "Hegel", "given": "J Kolja", "initials": "JK"}, {"family": "Tauber", "given": "Rudolf", "initials": "R"}, {"family": "Somasundaram", "given": "Rajan", "initials": "R"}, {"family": "Kappert", "given": "Kai", "initials": "K"}], "type": "letter", "published": "2020-11-17", "journal": {"title": "J Infect", "issn": "1532-2742", "volume": null, "issue": null, "issn-l": "0163-4453"}, "abstract": null, "doi": "10.1016/j.jinf.2020.11.016", "pmid": "33217473", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S0163-4453(20)30711-8"}, {"db": "pmc", "key": "PMC7670934"}], "notes": [], "created": "2020-11-26T14:31:48.547Z", "modified": "2021-02-26T08:45:02.871Z"}, {"entity": "publication", "iuid": "9ca4b2c8bb234e6aaec0b39b03ce25c2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ca4b2c8bb234e6aaec0b39b03ce25c2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ca4b2c8bb234e6aaec0b39b03ce25c2"}}, "title": "Outcome of COVID-19 in multiple myeloma patients in relation to treatment.", "authors": [{"family": "Susek", "given": "K. H.,", "initials": "KH"}, {"family": "Gran", "given": "C.,", "initials": "C"}, {"family": "Ljunggren", "given": "H. G.,", "initials": "HG"}, {"family": "Alici", "given": "E.,", "initials": "E"}, {"family": "Nahi", "given": "H.", "initials": "H"}], "type": null, "published": "2020-11-17", "journal": {"title": "Eur J Haematol.", "issn": null, "issn-l": null, "volume": "105", "issue": "6", "pages": "751-754"}, "abstract": "COVID\u201019 has emerged as a global pandemic. Cancer patients have been reported to be at higher risk for adverse outcome of COVID\u201019. Studies are ongoing to decipher the risk factors and risk groups among cancer patients as well as strategies to refine treatment approaches. Here, we report eight patients with multiple myeloma that underwent immunomodulatory therapies with daratumumab or lenalidomide\u2010based combination treatments and one patient with smoldering multiple myeloma, all of which presented with symptomatic COVID\u201019. We report that patients that succumbed to COVID\u201019 presented with either progressive tumor disease under daratumumab treatment or were in remission under lenalidomide\u2010dexamethasone treatment.", "doi": "10.1111/ejh.13502", "pmid": null, "labels": {"Type: Journal article": null, "Funder: Vinnova": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Provided in the article: Characteristics, treatments, COVID-19-related outcomes, additional laboratory and clinical data for 9 patients", "description": null}], "notes": [], "created": "2020-11-04T16:20:40.991Z", "modified": "2021-02-26T08:45:48.516Z"}, {"entity": "publication", "iuid": "5c098e68a7284bf4bc17ae331fd69552", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c098e68a7284bf4bc17ae331fd69552.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c098e68a7284bf4bc17ae331fd69552"}}, "title": "Modelling the dispersion of SARS-CoV-2 on a dynamic network graph", "authors": [{"family": "Elofsson", "given": "Arne", "initials": "A"}, {"family": "Bryant", "given": "Patrick", "initials": "P"}], "type": null, "published": "2020-11-17", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Background When modelling the dispersion of an epidemic using R0, one only considers the average number of individuals each infected individual will infect. However, we know from extensive studies of social networks that there is significant variation in the number of connections and thus social contacts each individual has. Individuals with more social contacts are more likely to attract and spread infection. These individuals are likely the drivers of the epidemic, so-called superspreaders. When many superspreaders are immune, it becomes more difficult for the disease to spread, as the connectedness of the social network dramatically decreases. If one assumes all individuals being equally connected and thus as likely to spread disease as in a SIR model, this is not true.\r\n\r\nMethods To account for the impact of social network structure on epidemic development, we model the dispersion of SARS-CoV-2 on a dynamic preferential attachment graph which changes appearance proportional to observed mobility changes. We sample a serial interval distribution that determines the probability of dispersion for all infected nodes each day. We model the dispersion in different age groups using age-specific infection fatality rates. We vary the infection probabilities in different age groups and analyse the outcome.\r\n\r\nResults The impact of movement on network dynamics plays a crucial role in the spread of infections. We find that higher movement results in higher spread due to an increased probability of new connections being made within a social network. We show that saturation in the dispersion can be reached much earlier on a preferential attachment graph compared to spread on a random graph, which is more similar to estimations using R0.\r\n\r\nConclusions We provide a novel method for modelling epidemics by using a dynamic network structure related to observed mobility changes. The social network structure plays a crucial role in epidemic development, something that is often overlooked.", "doi": "10.1101/2020.10.19.20215046", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Genomics & transcriptomics": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "URL", "key": "https://github.com/patrickbryant1/epidemic_net", "description": "Code, data, and results related to modelling the spread of COVID-19 on a dynamic social network with spread reduction according to Google mobility changes"}], "notes": [], "created": "2020-11-17T13:24:02.281Z", "modified": "2022-11-09T08:21:07.257Z"}, {"entity": "publication", "iuid": "bb13de8cbe1a40c4890b291266d4ec34", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb13de8cbe1a40c4890b291266d4ec34.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb13de8cbe1a40c4890b291266d4ec34"}}, "title": "Global analysis of more than 50,000 SARS-CoV-2 genomes reveals epistasis between eight viral genes", "authors": [{"family": "Zeng", "given": "Hong Li", "initials": "HL"}, {"family": "Dichio", "given": "Vito", "initials": "V"}, {"family": "Rodr\u00edguez Horta", "given": "Edwin", "initials": "E"}, {"family": "Thorell", "given": "Kaisa", "initials": "K"}, {"family": "Aurell", "given": "Erik", "initials": "E"}], "type": "journal-article", "published": "2020-11-17", "journal": {"title": "Proc Natl Acad Sci USA", "issn": "0027-8424", "issn-l": "0027-8424", "volume": null, "issue": null, "pages": "202012331"}, "abstract": null, "doi": "10.1073/pnas.2012331117", "pmid": null, "labels": {"Type: Journal article": null, "Funder: H2020": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "URL", "key": "https://www.pnas.org/content/117/49/31519#sec-14", "description": "Data is included in the article and supplementary information"}], "notes": [], "created": "2020-11-18T10:56:55.452Z", "modified": "2021-11-18T10:22:35.025Z"}, {"entity": "publication", "iuid": "c2f01753f5bb4ec59ebe3c6b8efa29ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2f01753f5bb4ec59ebe3c6b8efa29ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2f01753f5bb4ec59ebe3c6b8efa29ca"}}, "title": "Case report and systematic review suggest that children may experience similar long-term effects to adults after clinical COVID-19.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "journal article", "published": "2020-11-17", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "volume": null, "issue": null, "issn-l": null}, "abstract": "Persistent symptoms in adults after COVID-19 are emerging and the term long COVID is increasingly appearing in the literature. However, paediatric data are scarce .\n\nThis paper contains a case report of five Swedish children and the long-term symptoms reported by their parents. It also includes a systematic literature review of the MEDLINE, EMBASE and Web of Science databases and the medRxiv/bioRxiv preprint servers up to 2 November 2020.\n\nThe five children with potential long covid had a median age of 12 years (range 9-15) and four were girls. They had symptoms for 6-8 months after their clinical diagnoses of COVID-19. None were hospitalised at diagnosis, but one was later admitted for peri-myocarditis. All five children had fatigue, dyspnoea, heart palpitations or chest pain and four had headaches, difficulties concentrating, muscle weakness, dizziness and sore throats. Some had improved after 6-8 months, but they all suffered from fatigue and none had fully returned to school. The systematic review identified 179 publications and 19 of these were deemed relevant and read in detail. None contained any information on long COVID in children.\n\nChildren may experience similar long COVID symptoms to adults and females may be more affected.", "doi": "10.1111/apa.15673", "pmid": "33205450", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Provided in the article: clinical data reported by parents of five children with long-term effects of COVID-19", "description": null}], "notes": [], "created": "2020-11-26T12:26:47.588Z", "modified": "2021-02-26T08:45:48.669Z"}, {"entity": "publication", "iuid": "fb3edae98f5e4ab289309ee5f0d9bba6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb3edae98f5e4ab289309ee5f0d9bba6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb3edae98f5e4ab289309ee5f0d9bba6"}}, "title": "A complicated way of boiling water: nuclear safety in water history.", "authors": [{"family": "Evens", "given": "Siegfried", "initials": "S"}], "type": "journal article", "published": "2020-11-17", "journal": {"title": "Water Hist", "issn": "1877-7236", "volume": null, "issue": null, "pages": "1-14", "issn-l": null}, "abstract": "Water and nuclear reactors are much closer intertwined than usually perceived. First, water is the source of the steam that drives the turbines of most nuclear power plants around the world. Next to generating electricity, water is the key to preventing accidents in nuclear plants. As uranium keeps on generating heat when the power plant is turned off, its core needs to be cooled continuously. This crucial connection between water and nuclear is focus of the paper. Nuclear safety will appear as relying heavily on earlier knowledge, institutions, and regulatory frameworks, which were related to water. The three parts of this article discuss technologies, actors and risks of nuclear power. Studying water as a resource in a much broader sense than being boiled for steam shows how determining water is to make nuclear power function. As this paper is part of a special issue, Water History in the time of COVID-19, it has undergone modified peer review.", "doi": "10.1007/s12685-020-00258-0", "pmid": "33224318", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "258"}, {"db": "pmc", "key": "PMC7671176"}], "notes": [], "created": "2020-11-27T10:30:21.178Z", "modified": "2020-11-27T10:30:21.198Z"}, {"entity": "publication", "iuid": "b4ad408a15f543c599c0cb75863ae60d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b4ad408a15f543c599c0cb75863ae60d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b4ad408a15f543c599c0cb75863ae60d"}}, "title": "Mitigating COVID-19 Impact on the Portuguese Population Mental Health: The Opportunity That Lies in Digital Mental Health.", "authors": [{"family": "Mendes-Santos", "given": "Cristina", "initials": "C"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Weiderpass", "given": "Elisabete", "initials": "E"}, {"family": "Santana", "given": "Rui", "initials": "R"}], "type": "journal article", "published": "2020-11-16", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "553345", "issn-l": "2296-2565"}, "abstract": "COVID-19 mitigation measures present unprecedented challenges in mental healthcare delivery, posing high risk to the mental health of at-risk populations, namely patients diagnosed with COVID-19, frontline healthcare providers, and those submitted to quarantine or isolation measures, as well as the general population. Ensuring safe and equitable access to mental healthcare by these groups entails resorting to innovative psychosocial intervention strategies, such as digital mental health. In this perspective piece, we describe the impact of COVID-19 on the Portuguese population's mental health, present an overview on initiatives developed to address the challenges currently faced by the Portuguese mental healthcare system, and discuss how the timely implementation of a comprehensive digital mental health strategy, coupling research, education, implementation, and quality assessment initiatives, might buffer COVID-19's impact on the Portuguese society.", "doi": "10.3389/fpubh.2020.553345", "pmid": "33313033", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7701327"}], "notes": [], "created": "2020-12-21T10:17:55.193Z", "modified": "2021-02-26T08:47:00.167Z"}, {"entity": "publication", "iuid": "300659f5bed046a18cd1b58ab66f9644", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/300659f5bed046a18cd1b58ab66f9644.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/300659f5bed046a18cd1b58ab66f9644"}}, "title": "International Study of Movement Behaviors in the Early Years (SUNRISE): Results from SUNRISE Sweden's Pilot and COVID-19 Study.", "authors": [{"family": "Delisle Nystr\u00f6m", "given": "Christine", "initials": "C"}, {"family": "Alexandrou", "given": "Christina", "initials": "C"}, {"family": "Henstr\u00f6m", "given": "Maria", "initials": "M"}, {"family": "Nilsson", "given": "Ellinor", "initials": "E"}, {"family": "Okely", "given": "Anthony D", "initials": "AD"}, {"family": "Wehbe El Masri", "given": "Serina", "initials": "S"}, {"family": "L\u00f6f", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2020-11-16", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "22", "pages": null}, "abstract": "The International Study of Movement Behaviors in the Early Years (SUNRISE) was initiated in response to the 2019 WHO guidelines for physical activity, sedentary behavior, and sleep in children aged 0-5 years. This Swedish pilot study aimed to: (i) assess the proportion of preschoolers meeting the guidelines, (ii) evaluate the feasibility of the methods for the SUNRISE study, and (iii) assess how movement behaviors have been affected in preschoolers during the COVID-19 pandemic. Physical activity and sleep (waist-worn ActiGraph); screen time and movement behaviors (parental questionnaire); motor skills (Ages and Stages Questionnaire); and executive functions (3 iPad games) were assessed in 100 Swedish preschoolers ( n = 58 boys). There were 19.4% of preschoolers (n = 14) who met the WHO guidelines. The motor skill and executive function assessments were feasible; however, 20% refused to wear the ActiGraph overnight. Additionally, during the pandemic Swedish children's physical activity, time spent outside on weekdays and weekend days, and screen time significantly increased (+53; +124; +68; +30min/day, respectively, all p-values \u2264 0.001). Methods for the SUNRISE study were feasible in a Swedish context; however, considerations to switch to a wrist-worn accelerometer should be made. Furthermore, children's physical activity increased during the pandemic, which is likely due to how the rules/restrictions were implemented in Sweden.", "doi": "10.3390/ijerph17228491", "pmid": "33207786", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "ijerph17228491"}], "notes": [], "created": "2020-11-27T09:52:00.784Z", "modified": "2022-11-09T08:22:22.764Z"}, {"entity": "publication", "iuid": "0d51904ea0864a848c8ab3a0f232cc54", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d51904ea0864a848c8ab3a0f232cc54.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d51904ea0864a848c8ab3a0f232cc54"}}, "title": "COVID-19 patients in intensive care develop predominantly oliguric acute kidney injury.", "authors": [{"family": "Luther", "given": "Tomas", "initials": "T"}, {"family": "B\u00fclow-Anderberg", "given": "Sara", "initials": "S"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Rubertsson", "given": "Sten", "initials": "S"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2020-11-15", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": "65", "issue": "3", "pages": "364-372"}, "abstract": "Acute kidney injury (AKI) is a syndrome of reduced glomerular filtration rate and/or reduced urine flow associated with mortality in corona virus disease 2019 (COVID-19). AKI is often associated with renal tissue damage, which may lead to chronic kidney disease. Biomarkers of tissue damage may identify patients of particular risk.\r\n\r\nIn a prospective observational study of 57 patients admitted to intensive care, AKI incidence and characteristics was evaluated according to KDIGO criteria and related to days after admission. Urinary albumin, Neutrophil Gelatinase-Associated Lipocalin (NGAL), Kidney Injury Molecule 1 (KIM-1) and Plasma Tissue Inhibitor of MetalloProteinase 2 (TIMP-2) were analysed in 52 patients at admission. The majority (n = 51, 89%) of patients developed AKI, and 27 (47%) patients had predominantly oliguric AKI where oliguria was more severe than plasma Creatinine increase. Severe oliguria within first 2 days after admission was common (n = 37, 65%), whereas stage 2 and 3 AKI due to Creatinine occurred later than day 2 in 67% (12/18) of cases. Renal replacement therapy was started in 9 (16%) patients, and 30-day mortality was 28%. Urinary biomarkers were increased in a majority of patients, but did not robustly predict KDIGO stage. Most patients had microalbuminuria, and severe albuminuria (albumin Creatinine ratio > 30 mg/mmol) was found in n = 9 (17%) patients.\r\n\r\nA majority of patients with COVID-19 admitted to the ICU develop AKI. The functional deficit is often low urinary volume, and initial levels of biomarkers are generally increased without clear relation to final AKI stage.", "doi": "10.1111/aas.13746", "pmid": "33190222", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT04316884", "description": null}], "notes": [], "created": "2020-11-30T16:21:03.364Z", "modified": "2021-06-13T14:16:05.611Z"}, {"entity": "publication", "iuid": "80604ed113e244199546e41b2aaeb597", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/80604ed113e244199546e41b2aaeb597.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/80604ed113e244199546e41b2aaeb597"}}, "title": "Progress report on new antiepileptic drugs: A summary of the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV). I. Drugs in preclinical and early clinical development.", "authors": [{"family": "Bialer", "given": "Meir", "initials": "M"}, {"family": "Johannessen", "given": "Svein I", "initials": "SI"}, {"family": "Koepp", "given": "Matthias J", "initials": "MJ"}, {"family": "Levy", "given": "Ren\u00e9 H", "initials": "RH"}, {"family": "Perucca", "given": "Emilio", "initials": "E"}, {"family": "Perucca", "given": "Piero", "initials": "P"}, {"family": "Tomson", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "White", "given": "H Steve", "initials": "HS"}], "type": "journal article", "published": "2020-11-14", "journal": {"title": "Epilepsia", "issn": "1528-1167", "volume": null, "issue": null, "pages": null, "issn-l": "0013-9580"}, "abstract": "Since 1992, the Eilat Conferences have provided a forum for all stakeholders in the epilepsy community to appraise the latest data on new antiepileptic drugs and emergency seizure treatments, including, in recent years, updates on progress with the development of novel monitoring and therapeutic devices. Because of the COVID-19 pandemic, the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV) was held as a fully virtual conference on July 27-30, 2020 for the sessions on drugs and on August 3, 2020 for the sessions on devices, and was attended during the 5 days by >500 participants from 63 countries. This progress report summarizes key preclinical and initial (phase 1) clinical data on eight investigational treatments that are currently in early development, including 2-deoxy-D-glucose, GAO-3-02, JNJ-40411813, NBI-921352, NTX-001, sec-butylpropylacetamide, XEN1101, and XEN496. This report provides an overview of current scenarios in the area of treatment discovery and development. The information presented illustrates a variety of innovative strategies, including exploration of compounds with novel mechanisms of action, transplantation of interneurons into epileptogenic brain regions, and the targeting of rare, previously neglected syndromes.", "doi": "10.1111/epi.16725", "pmid": "33190243", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-27T09:56:44.967Z", "modified": "2020-11-27T09:57:08.067Z"}, {"entity": "publication", "iuid": "098e78feb6644af587ed79f4227ad801", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/098e78feb6644af587ed79f4227ad801.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/098e78feb6644af587ed79f4227ad801"}}, "title": "Mortality in Norway and Sweden before and after the Covid-19 outbreak: a cohort study", "authors": [{"family": "Juul", "given": "Frederik E", "initials": "FE"}, {"family": "Jodal", "given": "Henriette C", "initials": "HC"}, {"family": "Barua", "given": "Ishita", "initials": "I"}, {"family": "Refsum", "given": "Erle", "initials": "E"}, {"family": "Olsvik", "given": "\u00d8rjan", "initials": "\u00d8"}, {"family": "Helsingen", "given": "Lise M", "initials": "LM"}, {"family": "L\u00f8berg", "given": "Magnus", "initials": "M"}, {"family": "Bretthauer", "given": "Michael", "initials": "M"}, {"family": "Kalager", "given": "Mette", "initials": "M"}, {"family": "Emilsson", "given": "Louise", "initials": "L"}], "type": "posted-content", "published": "2020-11-13", "journal": {"title": "", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.11.11.20229708", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-10T04:25:00.880Z", "modified": "2021-06-10T04:25:46.265Z"}, {"entity": "publication", "iuid": "7c3d20509f2741158f4b2fd57038223d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7c3d20509f2741158f4b2fd57038223d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7c3d20509f2741158f4b2fd57038223d"}}, "title": "JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality.", "authors": [{"family": "Stebbing", "given": "Justin", "initials": "J"}, {"family": "S\u00e1nchez Nievas", "given": "Gin\u00e9s", "initials": "G"}, {"family": "Falcone", "given": "Marco", "initials": "M"}, {"family": "Youhanna", "given": "Sonia", "initials": "S"}, {"family": "Richardson", "given": "Peter", "initials": "P"}, {"family": "Ottaviani", "given": "Silvia", "initials": "S"}, {"family": "Shen", "given": "Joanne X", "initials": "JX"}, {"family": "Sommerauer", "given": "Christian", "initials": "C"}, {"family": "Tiseo", "given": "Giusy", "initials": "G"}, {"family": "Ghiadoni", "given": "Lorenzo", "initials": "L"}, {"family": "Virdis", "given": "Agostino", "initials": "A"}, {"family": "Monzani", "given": "Fabio", "initials": "F"}, {"family": "Rizos", "given": "Luis Romero", "initials": "LR"}, {"family": "Forfori", "given": "Francesco", "initials": "F"}, {"family": "Avenda\u00f1o-C\u00e9spedes", "given": "Almudena", "initials": "A"}, {"family": "De Marco", "given": "Salvatore", "initials": "S"}, {"family": "Carrozzi", "given": "Laura", "initials": "L"}, {"family": "Lena", "given": "Fabio", "initials": "F"}, {"family": "S\u00e1nchez-Jurado", "given": "Pedro Manuel", "initials": "PM"}, {"family": "Lacerenza", "given": "Leonardo Gianluca", "initials": "LG"}, {"family": "Cesira", "given": "Nencioni", "initials": "N"}, {"family": "Caldevilla-Bernardo", "given": "David", "initials": "D"}, {"family": "Perrella", "given": "Antonio", "initials": "A"}, {"family": "Niccoli", "given": "Laura", "initials": "L"}, {"family": "M\u00e9ndez", "given": "Lourdes S\u00e1ez", "initials": "LS"}, {"family": "Matarrese", "given": "Daniela", "initials": "D"}, {"family": "Goletti", "given": "Delia", "initials": "D"}, {"family": "Tan", "given": "Yee-Joo", "initials": "Y"}, {"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Dranitsaris", "given": "George", "initials": "G"}, {"family": "Cantini", "given": "Fabrizio", "initials": "F"}, {"family": "Farcomeni", "given": "Alessio", "initials": "A"}, {"family": "Dutta", "given": "Shuchismita", "initials": "S"}, {"family": "Burley", "given": "Stephen K", "initials": "SK"}, {"family": "Zhang", "given": "Haibo", "initials": "H"}, {"family": "Pistello", "given": "Mauro", "initials": "M"}, {"family": "Li", "given": "William", "initials": "W"}, {"family": "Mas Romero", "given": "Marta", "initials": "M"}, {"family": "Andr\u00e9s Pretel", "given": "Fernando", "initials": "F"}, {"family": "Sim\u00f3n-Talero", "given": "Rafaela S\u00e1nchez", "initials": "RS"}, {"family": "Garc\u00eda-Molina", "given": "Rafael", "initials": "R"}, {"family": "Kutter", "given": "Claudia", "initials": "C"}, {"family": "Felce", "given": "James H", "initials": "JH"}, {"family": "Nizami", "given": "Zehra F", "initials": "ZF"}, {"family": "Miklosi", "given": "Andras G", "initials": "AG"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}, {"family": "Menichetti", "given": "Francesco", "initials": "F"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Abizanda", "given": "Pedro", "initials": "P"}, {"family": "Lauschke", "given": "Volker M", "initials": "VM"}], "type": "journal article", "published": "2020-11-13", "journal": {"title": "Sci Adv", "issn": "2375-2548", "issn-l": "2375-2548", "volume": "7", "issue": "1", "pages": null}, "abstract": "Using AI we identified baricitinib as possessing anti-viral and anti-cytokine efficacy. We now show a 71% (95% CI 0.15-0.58) mortality benefit in 83 patients with moderate-severe SARS-CoV-2 pneumonia with few drug-induced adverse events, including a large elderly cohort (median age 81 years). A further 48 cases with mild-moderate pneumonia recovered uneventfully. Using organotypic 3D cultures of primary human liver cells, we demonstrate that interferon-alpha-2 (IFN\u03b12) significantly increases ACE2 expression and SARS-CoV-2 infectivity in parenchymal cells by >5-fold. RNA-Seq reveals gene response signatures associated with platelet activation, fully inhibited by baricitinib. Using viral load quantifications and super-resolution microscopy, baricitinib exerts activity rapidly through the inhibition of host proteins (numb associated kinases), uniquely amongst anti-virals. This reveals mechanistic actions of a Janus kinase-1/2 inhibitor targeting viral entry, replication and the cytokine storm, and is associated with beneficial outcomes including in severely ill elderly patients, data that incentivizes further randomized controlled trials.", "doi": "10.1126/sciadv.abe4724", "pmid": "33187978", "labels": {"Type: Journal article": null, "Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-9711/", "description": "Array Express E-MTAB-9711: RNA-seq of SARS-CoV-2-infected human primary hepatocyte-derived spheroids upon interferon a2 and baricitinib treatment"}, {"db": "URL", "key": "http://advances.sciencemag.org/cgi/content/full/sciadv.abe4724/DC1", "description": "Supplementary information"}], "notes": [], "created": "2020-11-18T15:27:10.197Z", "modified": "2021-06-13T14:16:56.042Z"}, {"entity": "publication", "iuid": "ea3e7e32fe0a47af92fac82feeace707", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ea3e7e32fe0a47af92fac82feeace707.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ea3e7e32fe0a47af92fac82feeace707"}}, "title": "The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19.", "authors": [{"family": "Consiglio", "given": "Camila Rosat", "initials": "CR", "orcid": "0000-0002-8901-2328", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/583a255a08b64095b9c4642911e1a922.json"}}, {"family": "Cotugno", "given": "Nicola", "initials": "N", "orcid": "0000-0002-7748-1581", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e39b95146ec4289b4efd91f869e2853.json"}}, {"family": "Sardh", "given": "Fabian", "initials": "F"}, {"family": "Pou", "given": "Christian", "initials": "C"}, {"family": "Amodio", "given": "Donato", "initials": "D", "orcid": "0000-0003-4550-3018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8036babccffd453ab3dda55c13a204fa.json"}}, {"family": "Rodriguez", "given": "Lucie", "initials": "L", "orcid": "0000-0002-3692-9060", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47b10420d4f449929ff0221bf881c7c4.json"}}, {"family": "Tan", "given": "Ziyang", "initials": "Z"}, {"family": "Zicari", "given": "Sonia", "initials": "S", "orcid": "0000-0003-1240-8057", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0379fd354fd3492aa5d5fe8ea9e16065.json"}}, {"family": "Ruggiero", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-1041-7489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e47b6216d0514a37818f676dce75ff57.json"}}, {"family": "Pascucci", "given": "Giuseppe Rubens", "initials": "GR", "orcid": "0000-0002-5978-1193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cfa33536b1242949e2195412e11f541.json"}}, {"family": "Santilli", "given": "Veronica", "initials": "V"}, {"family": "Campbell", "given": "Tessa", "initials": "T"}, {"family": "Bryceson", "given": "Yenan", "initials": "Y"}, {"family": "Eriksson", "given": "Daniel", "initials": "D"}, {"family": "Wang", "given": "Jun", "initials": "J"}, {"family": "Marchesi", "given": "Alessandra", "initials": "A"}, {"family": "Lakshmikanth", "given": "Tadepally", "initials": "T", "orcid": "0000-0001-7256-5770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a119d704e3594d66ae78021072a8f9ba.json"}}, {"family": "Campana", "given": "Andrea", "initials": "A"}, {"family": "Villani", "given": "Alberto", "initials": "A", "orcid": "0000-0002-9120-0424", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5005156054ed4498b7d938cbb7caf42e.json"}}, {"family": "Rossi", "given": "Paolo", "initials": "P"}, {"family": "CACTUS Study Team", "given": "", "initials": ""}, {"family": "Landegren", "given": "Nils", "initials": "N"}, {"family": "Palma", "given": "Paolo", "initials": "P", "orcid": "0000-0002-3066-4719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36e1a02e86a142c2b2d131154fb46f1c.json"}}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}], "type": "journal article", "published": "2020-11-12", "journal": {"title": "Cell", "issn": "1097-4172", "issn-l": "0092-8674", "volume": "183", "issue": "4", "pages": "968-981.e7"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is typically very mild and often asymptomatic in children. A complication is the rare multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, presenting 4-6 weeks after infection as high fever, organ dysfunction, and strongly elevated markers of inflammation. The pathogenesis is unclear but has overlapping features with Kawasaki disease suggestive of vasculitis and a likely autoimmune etiology. We apply systems-level analyses of blood immune cells, cytokines, and autoantibodies in healthy children, children with Kawasaki disease enrolled prior to COVID-19, children infected with SARS-CoV-2, and children presenting with MIS-C. We find that the inflammatory response in MIS-C differs from the cytokine storm of severe acute COVID-19, shares several features with Kawasaki disease, but also differs from this condition with respect to T cell subsets, interleukin (IL)-17A, and biomarkers associated with arterial damage. Finally, autoantibody profiling suggests multiple autoantibodies that could be involved in the pathogenesis of MIS-C.", "doi": "10.1016/j.cell.2020.09.016", "pmid": "32966765", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biomarkers and systems immunology": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pmc", "key": "PMC7474869"}, {"db": "pii", "key": "S0092-8674(20)31157-0"}], "notes": [], "created": "2020-10-28T09:09:22.496Z", "modified": "2023-06-19T15:18:37.668Z"}, {"entity": "publication", "iuid": "ff7aae8db2064115877b39738a00bea8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff7aae8db2064115877b39738a00bea8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff7aae8db2064115877b39738a00bea8"}}, "title": "Sleep and circadian problems during the coronavirus disease 2019 (COVID-19) pandemic: the International COVID-19 Sleep Study (ICOSS).", "authors": [{"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Chung", "given": "Frances", "initials": "F"}, {"family": "Penzel", "given": "Thomas", "initials": "T"}, {"family": "Espie", "given": "Colin A", "initials": "CA"}, {"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "ICOSS-collaboration group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-12", "journal": {"title": "J Sleep Res", "issn": "1365-2869", "volume": null, "issue": null, "pages": "e13206", "issn-l": "0962-1105"}, "abstract": "This protocol paper describes the development of an international collaboration to survey several thousand adults from different countries around the world about their sleep during the coronavirus disease 2019 (COVID-19) pandemic. It is based on the development of a harmonised survey with 50 questions (106 different items) on sleep habits and sleep symptoms that permit comparability of information. The harmonised questionnaire may be used in anonymous cross-sectional surveys, and the instruments within the questionnaire may also be used in prospective studies and clinical studies. The aim was to develop a questionnaire to sample a variety of sleep-wake disorders and other symptoms likely to be caused by prolonged social confinement or by having had COVID-19. The questionnaire was designed to be: (a) simple and, (b) free to use, for research purposes, (c) multilingual, and (d) comprehensive. It can be completed in <30 min. By the end of June 2020, the survey questionnaire had been administered in Austria, Canada, China, Finland, France, Germany, Hong Kong, Italy, Japan, Norway, Poland, Sweden, UK and USA. Research questions to be addressed by the pooled data derived from the participating sites focus on describing the nature and rates of various sleep and circadian rhythms symptoms, as well as their psychological and medical correlates, that arise at various points during the COVID-19 pandemic.", "doi": "10.1111/jsr.13206", "pmid": "33179820", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-30T16:29:23.154Z", "modified": "2020-11-30T16:29:23.163Z"}, {"entity": "publication", "iuid": "c7c21924c4be4ba2893c3de7f6790186", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7c21924c4be4ba2893c3de7f6790186.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7c21924c4be4ba2893c3de7f6790186"}}, "title": "Local topology, bifurcations and mutation hot-spots in proteins with SARS-CoV-2 spike protein as an example", "authors": [{"family": "Peng", "given": "Xubiao", "initials": "X"}, {"family": "Niemi", "given": "Antti J", "initials": "AJ"}], "type": "posted-content", "published": "2020-11-12", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.11.11.378828", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-03-08T15:03:36.462Z", "modified": "2021-04-15T19:03:01.894Z"}, {"entity": "publication", "iuid": "9c6ba4d480da4d18b2fcab1258dfd2e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9c6ba4d480da4d18b2fcab1258dfd2e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9c6ba4d480da4d18b2fcab1258dfd2e8"}}, "title": "Impact of COVID-19 pandemic on tuberculosis laboratory services in Europe.", "authors": [{"family": "Nikolayevskyy", "given": "Vlad", "initials": "V"}, {"family": "Holicka", "given": "Yen", "initials": "Y"}, {"family": "van Soolingen", "given": "Dick", "initials": "D"}, {"family": "van der Werf", "given": "Marieke J", "initials": "MJ"}, {"family": "K\u00f6dm\u00f6n", "given": "Csaba", "initials": "C"}, {"family": "Surkova", "given": "Elena", "initials": "E"}, {"family": "Hillemann", "given": "Doris", "initials": "D"}, {"family": "Groenheit", "given": "Ramona", "initials": "R"}, {"family": "Cirillo", "given": "Daniela", "initials": "D"}, {"family": "ERLTB-Net-2 study participants", "given": "", "initials": ""}], "type": "letter", "published": "2020-11-12", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "volume": null, "issue": null, "issn-l": "0903-1936"}, "abstract": null, "doi": "10.1183/13993003.03890-2020", "pmid": "33184119", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "13993003.03890-2020"}, {"db": "pmc", "key": "PMC7670866"}], "notes": [], "created": "2020-11-30T16:31:37.720Z", "modified": "2020-11-30T16:31:37.730Z"}, {"entity": "publication", "iuid": "10a1d6d31cd04809a438e3081949f053", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/10a1d6d31cd04809a438e3081949f053.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/10a1d6d31cd04809a438e3081949f053"}}, "title": "Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial.", "authors": [{"family": "Ponikowski", "given": "Piotr", "initials": "P"}, {"family": "Kirwan", "given": "Bridget-Anne", "initials": "BA"}, {"family": "Anker", "given": "Stefan D", "initials": "SD"}, {"family": "McDonagh", "given": "Theresa", "initials": "T"}, {"family": "Dorobantu", "given": "Maria", "initials": "M"}, {"family": "Drozdz", "given": "Jaros\u0142aw", "initials": "J"}, {"family": "Fabien", "given": "Vincent", "initials": "V"}, {"family": "Filippatos", "given": "Gerasimos", "initials": "G"}, {"family": "G\u00f6hring", "given": "Udo Michael", "initials": "UM"}, {"family": "Keren", "given": "Andre", "initials": "A"}, {"family": "Khintibidze", "given": "Irakli", "initials": "I"}, {"family": "Kragten", "given": "Hans", "initials": "H"}, {"family": "Martinez", "given": "Felipe A", "initials": "FA"}, {"family": "Metra", "given": "Marco", "initials": "M"}, {"family": "Milicic", "given": "Davor", "initials": "D"}, {"family": "Nicolau", "given": "Jos\u00e9 C", "initials": "JC"}, {"family": "Ohlsson", "given": "Marcus", "initials": "M"}, {"family": "Parkhomenko", "given": "Alexander", "initials": "A"}, {"family": "Pascual-Figal", "given": "Domingo A", "initials": "DA"}, {"family": "Ruschitzka", "given": "Frank", "initials": "F"}, {"family": "Sim", "given": "David", "initials": "D"}, {"family": "Skouri", "given": "Hadi", "initials": "H"}, {"family": "van der Meer", "given": "Peter", "initials": "P"}, {"family": "Lewis", "given": "Basil S", "initials": "BS"}, {"family": "Comin-Colet", "given": "Josep", "initials": "J"}, {"family": "von Haehling", "given": "Stephan", "initials": "S"}, {"family": "Cohen-Solal", "given": "Alain", "initials": "A"}, {"family": "Danchin", "given": "Nicolas", "initials": "N"}, {"family": "Doehner", "given": "Wolfram", "initials": "W"}, {"family": "Dargie", "given": "Henry J", "initials": "HJ"}, {"family": "Motro", "given": "Michael", "initials": "M"}, {"family": "Butler", "given": "Javed", "initials": "J"}, {"family": "Friede", "given": "Tim", "initials": "T"}, {"family": "Jensen", "given": "Klaus H", "initials": "KH"}, {"family": "Pocock", "given": "Stuart", "initials": "S"}, {"family": "Jankowska", "given": "Ewa A", "initials": "EA"}, {"family": "AFFIRM-AHF investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-12", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "396", "issue": "10266", "pages": "1895-1904", "issn-l": "0140-6736"}, "abstract": "Intravenous ferric carboxymaltose has been shown to improve symptoms and quality of life in patients with chronic heart failure and iron deficiency. We aimed to evaluate the effect of ferric carboxymaltose, compared with placebo, on outcomes in patients who were stabilised after an episode of acute heart failure.\n\nAFFIRM-AHF was a multicentre, double-blind, randomised trial done at 121 sites in Europe, South America, and Singapore. Eligible patients were aged 18 years or older, were hospitalised for acute heart failure with concomitant iron deficiency (defined as ferritin <100 \u03bcg/L, or 100-299 \u03bcg/L with transferrin saturation <20%), and had a left ventricular ejection fraction of less than 50%. Before hospital discharge, participants were randomly assigned (1:1) to receive intravenous ferric carboxymaltose or placebo for up to 24 weeks, dosed according to the extent of iron deficiency. To maintain masking of patients and study personnel, treatments were administered in black syringes by personnel not involved in any study assessments. The primary outcome was a composite of total hospitalisations for heart failure and cardiovascular death up to 52 weeks after randomisation, analysed in all patients who received at least one dose of study treatment and had at least one post-randomisation data point. Secondary outcomes were the composite of total cardiovascular hospitalisations and cardiovascular death; cardiovascular death; total heart failure hospitalisations; time to first heart failure hospitalisation or cardiovascular death; and days lost due to heart failure hospitalisations or cardiovascular death, all evaluated up to 52 weeks after randomisation. Safety was assessed in all patients for whom study treatment was started. A pre-COVID-19 sensitivity analysis on the primary and secondary outcomes was prespecified. This study is registered with ClinicalTrials.gov, NCT02937454, and has now been completed.\n\nBetween March 21, 2017, and July 30, 2019, 1525 patients were screened, of whom 1132 patients were randomly assigned to study groups. Study treatment was started in 1110 patients, and 1108 (558 in the carboxymaltose group and 550 in the placebo group) had at least one post-randomisation value. 293 primary events (57\u00b72 per 100 patient-years) occurred in the ferric carboxymaltose group and 372 (72\u00b75 per 100 patient-years) occurred in the placebo group (rate ratio [RR] 0\u00b779, 95% CI 0\u00b762-1\u00b701, p=0\u00b7059). 370 total cardiovascular hospitalisations and cardiovascular deaths occurred in the ferric carboxymaltose group and 451 occurred in the placebo group (RR 0\u00b780, 95% CI 0\u00b764-1\u00b700, p=0\u00b7050). There was no difference in cardiovascular death between the two groups (77 [14%] of 558 in the ferric carboxymaltose group vs 78 [14%] in the placebo group; hazard ratio [HR] 0\u00b796, 95% CI 0\u00b770-1\u00b732, p=0\u00b781). 217 total heart failure hospitalisations occurred in the ferric carboxymaltose group and 294 occurred in the placebo group (RR 0\u00b774; 95% CI 0\u00b758-0\u00b794, p=0\u00b7013). The composite of first heart failure hospitalisation or cardiovascular death occurred in 181 (32%) patients in the ferric carboxymaltose group and 209 (38%) in the placebo group (HR 0\u00b780, 95% CI 0\u00b766-0\u00b798, p=0\u00b7030). Fewer days were lost due to heart failure hospitalisations and cardiovascular death for patients assigned to ferric carboxymaltose compared with placebo (369 days per 100 patient-years vs 548 days per 100 patient-years; RR 0\u00b767, 95% CI 0\u00b747-0\u00b797, p=0\u00b7035). Serious adverse events occurred in 250 (45%) of 559 patients in the ferric carboxymaltose group and 282 (51%) of 551 patients in the placebo group.\n\nIn patients with iron deficiency, a left ventricular ejection fraction of less than 50%, and who were stabilised after an episode of acute heart failure, treatment with ferric carboxymaltose was safe and reduced the risk of heart failure hospitalisations, with no apparent effect on the risk of cardiovascular death.\n\nVifor Pharma.", "doi": "10.1016/S0140-6736(20)32339-4", "pmid": "33197395", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT02937454"}], "notes": [], "created": "2020-11-27T10:49:53.803Z", "modified": "2021-02-26T08:45:47.859Z"}, {"entity": "publication", "iuid": "8658ad0b159241be8e65c5b4f84da1dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8658ad0b159241be8e65c5b4f84da1dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8658ad0b159241be8e65c5b4f84da1dd"}}, "title": "Treating exuberant, non-resolving inflammation in the lung; Implications for acute respiratory distress syndrome and COVID-19.", "authors": [{"family": "Gilroy", "given": "Derek W", "initials": "DW"}, {"family": "De Maeyer", "given": "Roel P H", "initials": "RPH"}, {"family": "Tepper", "given": "Mark", "initials": "M"}, {"family": "O'Brien", "given": "Alastair", "initials": "A"}, {"family": "Uddin", "given": "Mohib", "initials": "M"}, {"family": "Chen", "given": "Judy", "initials": "J"}, {"family": "Goldstein", "given": "Daniel R", "initials": "DR"}, {"family": "Akbar", "given": "Arne N", "initials": "AN"}], "type": "journal article", "published": "2020-11-11", "journal": {"title": "Pharmacol Ther", "issn": "1879-016X", "volume": null, "issue": null, "pages": "107745", "issn-l": "0163-7258"}, "abstract": "While COVID-19, the disease driven by SARS-CoV-2 has ignited interest in the host immune response to this infection, it has also highlighted the lack of treatment options for the damaging inflammatory responses driven by pathogens that precipitate the acute respiratory distress syndrome (ARDS). With the global prevalence of SARS-CoV-2 and the likelihood of a second winter spike alongside seasonal flu, the need for effective and targeted anti-inflammatory agents is even more pressing. Here we discuss the aetiology of COVID-19 and the common signalling pathways driven by SARS-CoV-2, namely p38 MAP kinase. We highlight that p38 MAP kinase becomes elevated with increasing age, thereby driving many of the inflammatory pathways that precipitate death in old people with the added drawback of impairing vaccine efficacy in this susceptible age group. Finally, we review drugs available to inhibit p38 MAP kinase, their risks-versus-benefits as well as suggested dosing regimen to combat over-exuberant innate immune responses and potentially reverse vaccine inefficacy in older patients.", "doi": "10.1016/j.pharmthera.2020.107745", "pmid": "33188794", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0163-7258(20)30276-X"}, {"db": "pmc", "key": "PMC7657264"}], "notes": [], "created": "2020-11-27T11:01:14.577Z", "modified": "2020-11-27T11:03:48.877Z"}, {"entity": "publication", "iuid": "325ff1ba4f774ef5a692444fdd4878c1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/325ff1ba4f774ef5a692444fdd4878c1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/325ff1ba4f774ef5a692444fdd4878c1"}}, "title": "Long-distance airborne dispersal of SARS-CoV-2 in COVID-19 wards.", "authors": [{"family": "Nissen", "given": "Karolina", "initials": "K"}, {"family": "Krambrich", "given": "Janina", "initials": "J"}, {"family": "Akaberi", "given": "Dario", "initials": "D"}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Svensson", "given": "Lennart", "initials": "L"}, {"family": "Salaneck", "given": "Erik", "initials": "E"}], "type": "journal article", "published": "2020-11-11", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "10", "issue": "1", "pages": "19589"}, "abstract": "Evidence suggests that SARS-CoV-2, as well as other coronaviruses, can be dispersed and potentially transmitted by aerosols directly or via ventilation systems. We therefore investigated ventilation openings in one COVID-19 ward and central ducts that expel indoor air from three COVID-19 wards at Uppsala University Hospital, Sweden, during April and May 2020. Swab samples were taken from individual ceiling ventilation openings and surfaces in central ducts. Samples were subsequently subjected to rRT-PCR targeting the N and E genes of SARS-CoV-2. Central ventilation HEPA filters, located several stories above the wards, were removed and portions analyzed in the same manner. In two subsequent samplings, SARS-CoV-2 N and E genes were detected in seven and four out of 19 room vents, respectively. Central ventilation HEPA exhaust filters from the ward were found positive for both genes in three samples. Corresponding filters from two other, adjacent COVID-19 wards were also found positive. Infective ability of the samples was assessed by inoculation of susceptible cell cultures but could not be determined in these experiments. Detection of SARS-CoV-2 in central ventilation systems, distant from patient areas, indicate that virus can be transported long distances and that droplet transmission alone cannot reasonably explain this, especially considering the relatively low air change rates in these wards. Airborne transmission of SARS-CoV-2 must be taken into consideration for preventive measures.", "doi": "10.1038/s41598-020-76442-2", "pmid": "33177563", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-020-76442-2"}, {"db": "pmc", "key": "PMC7659316"}], "notes": [], "created": "2020-11-17T18:03:38.168Z", "modified": "2021-02-26T08:45:48.027Z"}, {"entity": "publication", "iuid": "028acc5d3ea24aa7b79c54b661dfed8d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/028acc5d3ea24aa7b79c54b661dfed8d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/028acc5d3ea24aa7b79c54b661dfed8d"}}, "title": "In silico and In vitro Studies Reveal Complement System Drives Coagulation Cascade in SARS-CoV-2 Pathogenesis.", "authors": [{"family": "Tiwari", "given": "Ritudhwaj", "initials": "R"}, {"family": "Mishra", "given": "Anurag R", "initials": "AR"}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "Gupta", "given": "Soham", "initials": "S"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}, {"family": "Nayak", "given": "Debasis", "initials": "D"}], "type": "journal article", "published": "2020-11-11", "journal": {"title": "Comput Struct Biotechnol J", "issn": "2001-0370", "volume": "18", "issue": null, "pages": "3734-3744", "issn-l": "2001-0370"}, "abstract": "The emergence and continued spread of SARS-CoV-2 have resulted in a public health emergency across the globe. The lack of knowledge on the precise mechanism of viral pathogenesis is impeding medical intervention. In this study, we have taken both in silico and in vitro experimental approaches to unravel the mechanism of viral pathogenesis associated with complement and coagulation pathways. Based on the structural similarities of viral and host proteins, we initially generated a protein-protein interactome profile. Further computational analysis combined with Gene Ontology (GO) analysis and KEGG pathway analysis predicted key annotated pathways associated with viral pathogenesis. These include MAPK signaling, complement, and coagulation cascades, endocytosis, PD-L1 expression, PD-1 checkpoint pathway in cancer and C-type lectin receptor signaling pathways. Degree centrality analysis pinned down to MAPK1, MAPK3, AKT1, and SRC are crucial drivers of signaling pathways and often overlap with the associated pathways. Most strikingly, the complement and coagulation cascade and platelet activation pathways are interconnected, presumably directing thrombotic activity observed in severe or critical cases of COVID-19. This is complemented by in vitro studies of Huh7 cell infection and analysis of the transcriptome and proteomic profile of gene candidates during viral infection. The most known candidates associated with complement and coagulation cascade signaling by KEGG pathway analysis showed significant up-regulated fold change during viral infection. Collectively both in silico and in vitro studies suggest complement and coagulation cascade signaling are a mechanism for intravascular coagulation, thrombotic changes, and associated complications in severe COVID-19 patients.", "doi": "10.1016/j.csbj.2020.11.005", "pmid": "33200027", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S2001-0370(20)30472-4"}, {"db": "pmc", "key": "PMC7657020"}], "notes": [], "created": "2020-11-19T19:43:58.111Z", "modified": "2021-04-23T15:18:24.542Z"}, {"entity": "publication", "iuid": "2042fa0ab0d14783b368a9ac51642f96", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2042fa0ab0d14783b368a9ac51642f96.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2042fa0ab0d14783b368a9ac51642f96"}}, "title": "How the Covid-19 pandemic is impacting sexual and reproductive health and rights and response: results from a global survey of providers, researchers, and policy makers.", "authors": [{"family": "Endler", "given": "Margit", "initials": "M"}, {"family": "Al-Haidari", "given": "Taghreed", "initials": "T"}, {"family": "Benedetto", "given": "Chiara", "initials": "C"}, {"family": "Chowdhury", "given": "Sameena", "initials": "S"}, {"family": "Christilaw", "given": "Jan", "initials": "J"}, {"family": "El Kak", "given": "Faysal", "initials": "F"}, {"family": "Galimberti", "given": "Diana", "initials": "D"}, {"family": "Garcia-Moreno", "given": "Claudia", "initials": "C"}, {"family": "Gutierrez", "given": "Miguel", "initials": "M"}, {"family": "Ibrahim", "given": "Shaimaa", "initials": "S"}, {"family": "Kumari", "given": "Shantha", "initials": "S"}, {"family": "McNicholas", "given": "Colleen", "initials": "C"}, {"family": "Mostajo Flores", "given": "Desir\u00e9e", "initials": "D"}, {"family": "Muganda", "given": "John", "initials": "J"}, {"family": "Ramirez-Negrin", "given": "Atziri", "initials": "A"}, {"family": "Senanayake", "given": "Hemantha", "initials": "H"}, {"family": "Sohail", "given": "Rubina", "initials": "R"}, {"family": "Temmerman", "given": "Marleen", "initials": "M"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}], "type": "journal article", "published": "2020-11-11", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": null, "issue": null, "issn-l": "0001-6349"}, "abstract": "We aimed to give a global overview of trends in access to sexual and reproductive health and rights (SRHR) during the Covid-19 pandemic and what is being done to mitigate its impact.\n\nWe performed a descriptive analysis and content analysis based on an online survey among clinicians, researchers and organizations. Our data was extracted from multiple-choice questions on access to SRHR services and risk of SRHR violations, and written responses to open-ended questions on threats to access and required response.\n\nThe survey was answered by 51 people representing 29 countries. 86% reported that access to contraceptive services was less or much less due to Covid-19, corresponding figures for surgical and medical abortion were 62% and 46%. The increased risk of gender-based and sexual violence was assessed as moderate or severe by 79%. Among countries with mildly restrictive abortion policies, 69% had implemented changes to facilitate access to abortion during the pandemic, compared to 0 among countries with severe restrictions (p<0.001), 87.5% compared to 46% had implemented changes to facilitate access to contraception (p= 0.023). The content analysis showed that i) prioritizations in health service delivery at the expense of SRHR, ii) lack of political will, iii) the detrimental effect of lock-down, and iv) the suspension of sexual education, were threats to SRHR access (theme 1). Requirements to mitigate these threats (theme 2) were i) political will and support of universal access to SRH services, ii) the sensitization of providers, vii) free public transport, and viii) physical protective equipment. A contrasting third theme was the state of exception of the Covid-19 pandemic as a window of opportunity to push forward women\u00b4s health and rights.\n\nMany countries have seen decreased access to and increased violations of SRHR during the Covid-19 pandemic. Countries with severe restrictions on abortion seem less likely to have implemented changes to SRHR delivery to mitigate this impact. Political will to support the advancement of SRHR is often lacking, which is fundamental to ensuring both continued access and, in a minority of cases, the solidification of gains made to SRHR during the pandemic.", "doi": "10.1111/aogs.14043", "pmid": "33179265", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-27T10:00:02.800Z", "modified": "2020-11-30T16:29:54.257Z"}, {"entity": "publication", "iuid": "dbfda0fdcd6d401ba68a4be038469ab5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dbfda0fdcd6d401ba68a4be038469ab5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dbfda0fdcd6d401ba68a4be038469ab5"}}, "title": "The issues of individualized medicine and pharmacovigilance: A consideration of COVID-19 and vaccination.", "authors": [{"family": "Ralph Edwards", "given": "I", "initials": "I"}, {"family": "Lindquist", "given": "Marie", "initials": "M"}], "type": "editorial", "published": "2020-11-10", "journal": {"title": "Int J Risk Saf Med", "issn": "1878-6847", "volume": "31", "issue": "4", "pages": "179-180", "issn-l": null}, "abstract": null, "doi": "10.3233/JRS-201008", "pmid": "33164947", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "JRS201008"}], "notes": [], "created": "2020-11-30T16:32:52.920Z", "modified": "2020-11-30T16:32:52.943Z"}, {"entity": "publication", "iuid": "af559716c7364d0bb301d8ef4144a058", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/af559716c7364d0bb301d8ef4144a058.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/af559716c7364d0bb301d8ef4144a058"}}, "title": "Surveillance of wastewater revealed peaks of SARS-CoV-2 preceding those of hospitalized patients with COVID-19.", "authors": [{"family": "Saguti", "given": "Fredy", "initials": "F"}, {"family": "Magnil", "given": "Ellen", "initials": "E"}, {"family": "Enache", "given": "Lucica", "initials": "L"}, {"family": "Churqui", "given": "Marianela Patzi", "initials": "MP"}, {"family": "Johansson", "given": "Anette", "initials": "A"}, {"family": "Lumley", "given": "Douglas", "initials": "D"}, {"family": "Davidsson", "given": "Fredrik", "initials": "F"}, {"family": "Dotevall", "given": "Leif", "initials": "L"}, {"family": "Mattsson", "given": "Ann", "initials": "A"}, {"family": "Trybala", "given": "Edward", "initials": "E"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Brezicka", "given": "Thomas", "initials": "T"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Norder", "given": "Hel\u00e9ne", "initials": "H"}], "type": "journal article", "published": "2020-11-10", "journal": {"title": "Water Res", "issn": "1879-2448", "issn-l": "0043-1354", "volume": "189", "issue": null, "pages": "116620"}, "abstract": "SARS-CoV-2 was discovered among humans in Wuhan, China in late 2019, and then spread rapidly, causing a global pandemic. The virus was found to be transmitted mainly by respiratory droplets from infected persons or by direct contact. It was also shown to be excreted in feces, why we investigated whether the virus could be detected in wastewater and if so, to which extent its levels reflects its spread in society. Samples of wastewater from the city of Gothenburg, and surrounding municipalities in Sweden were collected daily from mid-February until June 2020 at the Rya wastewater treatment plant. Flow proportional samples of wastewater were collected to ensure that comparable amounts were obtained for analysis. Daily samples were pooled into weekly samples. Virus was concentrated on a filter and analyzed by RT-qPCR. The amount of SARS-CoV-2 varied with peaks approximately every four week, preceding variations in number of newly hospitalized patients by 19-21 days. At that time virus testing for COVID-19 was limited to patients with severe symptoms. Local differences in viral spread was shown by analyzing weekly composite samples of wastewater from five sampling sites for four weeks. The highest amount of virus was found from the central, eastern, and northern parts of the city. SARS-CoV-2 was also found in the treated effluent wastewater from the WWTP discharged into the recipient, the G\u00f6ta River, although with a reduction of 4-log 10. The viral peaks with regular temporal intervals indicated that SARS-CoV-2 may have a cluster spread, probably reflecting that the majority of infected persons only spread the disease during a few days. Our results are important for both the planning of hospital care and to rapidly identify and intervene against local spread of the virus.", "doi": "10.1016/j.watres.2020.116620", "pmid": "33212338", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "NA", "key": "Provided in the article: amount of SARS-CoV-2 in wastewater in Gothenburg per week between February and June 2020", "description": null}], "notes": [], "created": "2020-11-24T07:37:09.624Z", "modified": "2021-02-26T08:46:13.439Z"}, {"entity": "publication", "iuid": "675c2e887707441982f23b3e80461e80", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/675c2e887707441982f23b3e80461e80.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/675c2e887707441982f23b3e80461e80"}}, "title": "Purchasing, consumption, demographic and socioeconomic variables associated with shifts in alcohol consumption during the COVID-19 pandemic.", "authors": [{"family": "Callinan", "given": "Sarah", "initials": "S"}, {"family": "Mojica-Perez", "given": "Yvette", "initials": "Y"}, {"family": "Wright", "given": "Cassandra J C", "initials": "CJC"}, {"family": "Livingston", "given": "Michael", "initials": "M"}, {"family": "Kuntsche", "given": "Sandra", "initials": "S"}, {"family": "Laslett", "given": "Anne-Marie", "initials": "A"}, {"family": "Room", "given": "Robin", "initials": "R"}, {"family": "Kuntsche", "given": "Emmanuel", "initials": "E"}], "type": "journal article", "published": "2020-11-10", "journal": {"title": "Drug Alcohol Rev", "issn": "1465-3362", "issn-l": "0959-5236", "volume": null, "issue": null, "pages": null}, "abstract": "Restrictions introduced to reduce the spread of COVID-19 have had major impacts on the living circumstances of Australians. This paper aims to provide insight into shifts in alcohol consumption and associated factors during the epidemic.\r\n\r\nA cross-sectional convenience sample of 2307 Australians aged 18 and over who drank at least monthly was recruited through social media. Respondents were asked about their alcohol consumption and purchasing in 2019 prior to the epidemic plus similar questions about their experiences in the month prior to being surveyed between 29 April and 16 May 2020.\r\n\r\nReports of average consumption before (3.53 drinks per day [3.36, 3.71 95% confidence interval]) and during (3.52 [3.34, 3.69]) the pandemic were stable. However, young men and those who drank more outside the home in 2019 reported decreased consumption during the pandemic, and people with high levels of stress and those who bulk-bought alcohol when restrictions were announced reported an increase in consumption relative to those who did not.\r\n\r\nA reported increase in consumption among those experiencing more stress suggests that some people may have been drinking to cope during the epidemic. Conversely, the reported decrease in consumption among those who drank more outside of their home in 2019 suggests that closing all on-trade sales did not result in complete substitution of on-premise drinking with home drinking in this group. Monitoring of relevant subgroups to assess long-term changes in consumption in the aftermath of the epidemic is recommended.", "doi": "10.1111/dar.13200", "pmid": "33170976", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2020-11-27T10:01:48.823Z", "modified": "2021-02-26T08:47:00.003Z"}, {"entity": "publication", "iuid": "a47dbc0890e6411dbb49a80752e594ad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a47dbc0890e6411dbb49a80752e594ad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a47dbc0890e6411dbb49a80752e594ad"}}, "title": "EAES Recommendations for Recovery Plan in Minimally Invasive Surgery Amid COVID-19 Pandemic.", "authors": [{"family": "Arezzo", "given": "Alberto", "initials": "A"}, {"family": "Francis", "given": "Nader", "initials": "N"}, {"family": "Mintz", "given": "Yoav", "initials": "Y"}, {"family": "Adamina", "given": "Michel", "initials": "M"}, {"family": "Antoniou", "given": "Stavros A", "initials": "SA"}, {"family": "Bouvy", "given": "Nicole", "initials": "N"}, {"family": "Copaescu", "given": "Catalin", "initials": "C"}, {"family": "de Manzini", "given": "Nicol\u00f2", "initials": "N"}, {"family": "Di Lorenzo", "given": "Nicola", "initials": "N"}, {"family": "Morales-Conde", "given": "Salvador", "initials": "S"}, {"family": "M\u00fcller-Stich", "given": "Beat P", "initials": "BP"}, {"family": "Nickel", "given": "Felix", "initials": "F"}, {"family": "Popa", "given": "Dorin", "initials": "D"}, {"family": "Tait", "given": "Diana", "initials": "D"}, {"family": "Thomas", "given": "Cenydd", "initials": "C"}, {"family": "Nimmo", "given": "Susan", "initials": "S"}, {"family": "Paraskevis", "given": "Dimitrios", "initials": "D"}, {"family": "Pietrabissa", "given": "Andrea", "initials": "A"}, {"family": "EAES Group of Experts for Recovery Amid COVID-19 Pandemic", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-10", "journal": {"title": "Surg Endosc", "issn": "1432-2218", "volume": null, "issue": null, "issn-l": null}, "abstract": "COVID-19 pandemic presented an unexpected challenge for the surgical community in general and Minimally Invasive Surgery (MIS) specialists in particular. This document aims to summarize recent evidence and experts' opinion and formulate recommendations to guide the surgical community on how to best organize the recovery plan for surgical activity across different sub-specialities after the COVID-19 pandemic.\n\nRecommendations were developed through a Delphi process for establishment of expert consensus. Domain topics were formulated and subsequently subdivided into questions pertinent to different surgical specialities following the COVID-19 crisis. Sixty-five experts from 24 countries, representing the entire EAES board, were invited. Fifty clinicians and six engineers accepted the invitation and drafted statements based on specific key questions. Anonymous voting on the statements was performed until consensus was achieved, defined by at least 70% agreement.\n\nA total of 92 consensus statements were formulated with regard to safe resumption of surgery across eight domains, addressing general surgery, upper GI, lower GI, bariatrics, endocrine, HPB, abdominal wall and technology/research. The statements addressed elective and emergency services across all subspecialties with specific attention to the role of MIS during the recovery plan. Eighty-four of the statements were approved during the first round of Delphi voting (91.3%) and another 8 during the following round after substantial modification, resulting in a 100% consensus.\n\nThe recommendations formulated by the EAES board establish a framework for resumption of surgery following COVID-19 pandemic with particular focus on the role of MIS across surgical specialities. The statements have the potential for wide application in the clinical setting, education activities and research work across different healthcare systems.", "doi": "10.1007/s00464-020-08131-0", "pmid": "33170335", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00464-020-08131-0"}, {"db": "pmc", "key": "PMC7653984"}], "notes": [], "created": "2020-11-30T16:30:45.726Z", "modified": "2020-11-30T16:30:45.750Z"}, {"entity": "publication", "iuid": "bb567e9f4e7a4b8c9a0463a6c345d634", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb567e9f4e7a4b8c9a0463a6c345d634.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb567e9f4e7a4b8c9a0463a6c345d634"}}, "title": "Prone positioning in mechanically ventilated patients with severe acute respiratory distress syndrome and coronavirus disease 2019.", "authors": [{"family": "Gleissman", "given": "Helena", "initials": "H"}, {"family": "Forsgren", "given": "Anders", "initials": "A"}, {"family": "Andersson", "given": "Elisabeth", "initials": "E"}, {"family": "Lindqvist", "given": "Elin", "initials": "E"}, {"family": "Lipka Falck", "given": "Adam", "initials": "A"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Dahlberg", "given": "Martin", "initials": "M"}, {"family": "G\u00fcnther", "given": "Mattias", "initials": "M"}], "type": "journal article", "published": "2020-11-09", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "volume": null, "issue": null, "issn-l": "0001-5172"}, "abstract": "The management of COVID-19 ARDS is debated. Although current evidence does not suggest an atypical acute respiratory distress syndrome (ARDS), the physiological response to prone positioning is not fully understood and it is unclear which patients benefit. We aimed to determine whether proning increases oxygenation and to evaluate responders.\n\nThis case series from a single, tertiary university hospital includes all mechanically ventilated patients with COVID-19 and proning between 17 March 2020 and 19 May 2020. The primary measure was change in PaO 2 :FiO2 .\n\nForty-four patients, 32 males/12 females, were treated with proning for a total of 138 sessions, with median (range) two (1-8) sessions. Median (IQR) time for the five sessions was 14 (12-17) hours. In the first session, median (IQR) PaO 2 :FiO2 increased from 104 (86-122) to 161 (127-207) mm Hg (P < .001). 36/44 patients (82%) improved in PaO2 :FiO2 , with a significant increase in PaO2 :FiO2 in the first three sessions. Median (IQR) FiO2 decreased from 0.7 (0.6-0.8) to 0.5 (0.35-0.6) (<0.001). A significant decrease occurred in the first three sessions. PaO2 , tidal volumes, PEEP, mean arterial pressure (MAP), and norepinephrine infusion did not differ. Primarily, patients with PaO2 :FiO2 approximately < 120 mm Hg before treatment responded to proning. Age, sex, BMI, or SAPS 3 did not predict success in increasing PaO2 :FiO2 .\n\nProning increased PaO 2 :FiO2 , primarily in patients with PaO2 :FiO2 approximately < 120 mm Hg, with a consistency over three sessions. No characteristic was associated with non-responding, why proning may be considered in most patients. Further study is required to evaluate mortality.", "doi": "10.1111/aas.13741", "pmid": "33165936", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-27T10:05:33.757Z", "modified": "2021-02-26T08:45:48.620Z"}, {"entity": "publication", "iuid": "fe33af25ffb64d688a4a3fb24a350de4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fe33af25ffb64d688a4a3fb24a350de4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fe33af25ffb64d688a4a3fb24a350de4"}}, "title": "COVID-19 during Pregnancy and Postpartum.", "authors": [{"family": "Naidu Ms PharmD", "given": "Sreus A G", "initials": "SAG"}, {"family": "Clemens DrPH Fift Cfs Fasn Facn Cns Fiafst", "given": "Roger A", "initials": "RA"}, {"family": "Pressman Md Ms Facn", "given": "Peter", "initials": "P"}, {"family": "Zaigham BSc Md PhD", "given": "Mehreen", "initials": "M"}, {"family": "Kadkhoda PhD Sm Ascp D Abmm D Abmli", "given": "Kamran", "initials": "K"}, {"family": "Davies PhD DSc Mae Frsc Frcp Fls Fri", "given": "Kelvin J A", "initials": "KJA"}, {"family": "Naidu PhD Facn Fls Fissvd", "given": "A Satyanarayan", "initials": "AS"}], "type": "journal article", "published": "2020-11-08", "journal": {"title": "J Diet Suppl", "issn": "1939-022X", "volume": null, "issue": null, "pages": "1-28", "issn-l": "1939-0211"}, "abstract": "Coronavirus Disease 2019 (COVID-19) triggered by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection has been declared a pandemic by the World Health Organization (WHO) on March 11, 2020. Oxidative stress and its related metabolic syndromes are potential risk factors in the susceptibility to, and severity of COVID-19. In concert with the earliest reports of COVID-19, obstetricians started to diagnose and treat SARS-CoV-2 infections during pregnancy (\"COVID-19-Pregnancy\"). High metabolic demand to sustain normal fetal development increases the burden of oxidative stress in pregnancy. Intracellular redox changes intertwined with acute phase responses at the maternal-fetal interface could amplify during pregnancy. Interestingly, mother-to-fetus transmission of SARS-CoV-2 has not been detected in most of the COVID-19-Pregnancy cases. This relative absence of vertical transmission may be related to the presence of lactoferrin in the placenta, amniotic fluid, and lacteal secretions. However, the cytokine-storm induced during COVID-19-Pregnancy may cause severe inflammatory damage to the fetus, and if uncontrolled, may later result in autism spectrum-like disorders and brain development abnormalities in neonates. Considering this serious health threat to child growth and development, the prevention of COVID-19 during pregnancy should be considered a high priority. This review summarizes the intricate virulence factors of COVID-19 and elucidate its pathobiological spectrum during pregnancy and postpartum periods with a focus on the putative and complex roles of endogenous and exogenous lactoferrin in conferring immunological advantage to the host.", "doi": "10.1080/19390211.2020.1834049", "pmid": "33164601", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-27T11:01:15.701Z", "modified": "2020-11-27T11:03:50.332Z"}, {"entity": "publication", "iuid": "e6ab3a8d7c344df9bb18ae2700312888", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6ab3a8d7c344df9bb18ae2700312888.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6ab3a8d7c344df9bb18ae2700312888"}}, "title": "How children and young people can stay physically active during the novel coronavirus pandemic while take into account safety measures and precautions.", "authors": [{"family": "Fr\u00f6berg", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2020-11-07", "journal": {"title": "Health Promot Perspect", "issn": "2228-6497", "volume": "10", "issue": "4", "pages": "295-299", "issn-l": null}, "abstract": "The novel coronavirus (COVID-19) outbreak has caused major public concern and posed challenges to societies across the globe. The COVID-19 pandemic might have implications for health-related behaviors, such as physical activity, among people in different age groups. Lately, a number of papers have offered suggestions and recommendations on how to stay physically active during the novel coronavirus pandemic while take into account safety measures and precautions. Many of these suggestions and recommendations might be relevant for health professionals and health practitioners working to facilitate physical activity, health, and well-being among children and young people. In light of the COVID-19pandemic, this paper provides an overview of (a) suggestions and recommendations on physical activities; and (b) safety measures and precautions while being physically active.", "doi": "10.34172/hpp.2020.47", "pmid": "33312924", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7722993"}], "notes": [], "created": "2020-12-21T10:18:32.884Z", "modified": "2021-02-26T08:47:00.269Z"}, {"entity": "publication", "iuid": "511d36d8ecdb449d868b55a96b910565", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/511d36d8ecdb449d868b55a96b910565.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/511d36d8ecdb449d868b55a96b910565"}}, "title": "Weak anti-SARS-CoV-2 antibody response is associated with mortality in a Swedish cohort of COVID-19 patients in critical care.", "authors": [{"family": "Asif", "given": "Sana", "initials": "S"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Kristensen", "given": "Bjarne", "initials": "B"}, {"family": "Alving", "given": "Kjell", "initials": "K"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}], "type": "journal article", "published": "2020-11-06", "journal": {"title": "Crit Care", "issn": "1466-609X", "issn-l": "1364-8535", "volume": "24", "issue": "1", "pages": "639"}, "abstract": null, "doi": "10.1186/s13054-020-03362-y", "pmid": "33158455", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-020-03362-y"}, {"db": "pmc", "key": "PMC7645408"}], "notes": [], "created": "2020-11-11T07:29:15.329Z", "modified": "2022-02-14T07:49:35.193Z"}, {"entity": "publication", "iuid": "42eac4db2cb44eb59410e1021db054ad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/42eac4db2cb44eb59410e1021db054ad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/42eac4db2cb44eb59410e1021db054ad"}}, "title": "Utility of Proteomics in Emerging and Re-Emerging Infectious Diseases Caused by RNA Viruses.", "authors": [{"family": "Sperk", "given": "Maike", "initials": "M"}, {"family": "van Domselaar", "given": "Robert", "initials": "R"}, {"family": "Rodriguez", "given": "Jimmy Esneider", "initials": "JE"}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "S\u00e1 Vinhas", "given": "Beatriz", "initials": "B"}, {"family": "Saccon", "given": "Elisa", "initials": "E"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Singh", "given": "Kamal", "initials": "K"}, {"family": "Gupta", "given": "Soham", "initials": "S"}, {"family": "V\u00e9gv\u00e1ri", "given": "\u00c1kos", "initials": "\u00c1"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "journal article", "published": "2020-11-06", "journal": {"title": "J Proteome Res", "issn": "1535-3907", "issn-l": null, "volume": "19", "issue": "11", "pages": "4259-4274"}, "abstract": "Emerging and re-emerging infectious diseases due to RNA viruses cause major negative consequences for the quality of life, public health, and overall economic development. Most of the RNA viruses causing illnesses in humans are of zoonotic origin. Zoonotic viruses can directly be transferred from animals to humans through adaptation, followed by human-to-human transmission, such as in human immunodeficiency virus (HIV), severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and, more recently, SARS coronavirus 2 (SARS-CoV-2), or they can be transferred through insects or vectors, as in the case of Crimean-Congo hemorrhagic fever virus (CCHFV), Zika virus (ZIKV), and dengue virus (DENV). At the present, there are no vaccines or antiviral compounds against most of these viruses. Because proteins possess a vast array of functions in all known biological systems, proteomics-based strategies can provide important insights into the investigation of disease pathogenesis and the identification of promising antiviral drug targets during an epidemic or pandemic. Mass spectrometry technology has provided the capacity required for the precise identification and the sensitive and high-throughput analysis of proteins on a large scale and has contributed greatly to unravelling key protein-protein interactions, discovering signaling networks, and understanding disease mechanisms. In this Review, we present an account of quantitative proteomics and its application in some prominent recent examples of emerging and re-emerging RNA virus diseases like HIV-1, CCHFV, ZIKV, and DENV, with more detail with respect to coronaviruses (MERS-CoV and SARS-CoV) as well as the recent SARS-CoV-2 pandemic.", "doi": "10.1021/acs.jproteome.0c00380", "pmid": "33095583", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7640957"}], "notes": [], "created": "2020-12-01T15:33:37.364Z", "modified": "2021-02-26T08:45:02.967Z"}, {"entity": "publication", "iuid": "7bb177f83a4e475e9037154ad9bdc8f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7bb177f83a4e475e9037154ad9bdc8f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7bb177f83a4e475e9037154ad9bdc8f1"}}, "title": "The Impact of COVID-19 on Criminal Investigations and Proceedings in Sweden - A Snapshot of Practitioners' Realities.", "authors": [{"family": "Lid\u00e9n", "given": "Moa", "initials": "M"}], "type": "journal article", "published": "2020-11-06", "journal": {"title": "Forensic Sci Int", "issn": "2589-871X", "issn-l": null, "volume": "2", "issue": null, "pages": "325-332"}, "abstract": "Since well-functioning criminal investigations and proceedings are crucial parts of a society governed by the rule of law, it is essential to understand whether and how they are impacted by the current COVID-19 pandemic. The Swedish context provides an interesting case study and comparison to developments in other countries which have introduced more far-reaching interventions such as lockdowns. In this study, Swedish practitioners (N =10), including police officers, forensic pathologists, prosecutors, defense counsels and judges, participated in an online survey in which they gave their views on the pandemic's impact on their work situations. The overall results show that the major impact was on their work methods, with transitions to using more online methods and increased remote working, while the smallest impact was noted in relation to work character, including crime and evidence types which have remained relatively constant. Forensic pathologists reported the largest impact on work quality, although there was large individual variation in their responses. On a general level, the practitioners perceived that the measures undertaken at their work places were relatively sufficient and also perceived of the risk of contracting or spreading the virus as relatively low but also this was associated with large individual variation. Given the small sample of practitioners and that practitioners' responses relate to an early stage of what is presumed to be a prolonged pandemic, replication as well as caution in interpreting the results are needed.", "doi": "10.1016/j.fsisyn.2020.11.001", "pmid": "33294832", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S2589-871X(20)30065-6"}, {"db": "pmc", "key": "PMC7689508"}], "notes": [], "created": "2020-12-13T07:20:58.444Z", "modified": "2022-11-09T08:25:07.841Z"}, {"entity": "publication", "iuid": "c493f63a0cbc43c396383a4cf1232f85", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c493f63a0cbc43c396383a4cf1232f85.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c493f63a0cbc43c396383a4cf1232f85"}}, "title": "Is It Just About Physical Health? An Online Cross-Sectional Study Exploring the Psychological Distress Among University Students in Jordan in the Midst of COVID-19 Pandemic.", "authors": [{"family": "Al-Tammemi", "given": "Ala'a B", "initials": "AB"}, {"family": "Akour", "given": "Amal", "initials": "A"}, {"family": "Alfalah", "given": "Laith", "initials": "L"}], "type": "journal article", "published": "2020-11-06", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "11", "issue": null, "pages": "562213"}, "abstract": "Since the spread of COVID-19 on a global scale, most of efforts at national and international levels were directed to mitigate the spread of the disease and its physical harm, paying less attention to the psychological impacts of COVID-19 on global mental health especially at early stages of the pandemic.\r\n\r\nThis study aimed to assess and explore (i) The levels of psychological distress and its correlates (ii) Motivation for distance learning (iii) Coping activities and pandemic related concerns, among university students in Jordan in the midst of COVID-19 pandemic.\r\n\r\nA cross-sectional study was conducted using an online self-administered questionnaire. The measure of psychological distress was obtained using the 10-item Kessler Psychological Distress Scale, while other questions have explored our study's second and third aims.\r\n\r\nA total of 381 completed questionnaires were included in the analysis. Female participants slightly predominated the sample ( n = 199, 52.2%). The respondents aged 18-38 years (mean 22.6 years, SD: 3.16). Concerning distress severity, most of respondents were regarded as having severe psychological distress (n = 265, 69.5%). 209 students (54.9%) reported that they had no motivation for distance learning. Ordinal logistic regression revealed a significant correlation between distress severity and many predictors. Among the predictors that were found to act as protective factors against higher levels of distress included older age (aOR = 0.64, P = 0.022; 95% CI: 0.44-0.94), and having a strong motivation for distance learning (aOR = 0.10, P = 0.048; 95% CI: 0.01-0.96). In contrary, being a current smoker (aOR = 1.99, P = 0.049; 95% CI: 1.10-3.39), and having no motivation for distance learning (aOR = 2.49, P = 0.007; 95% CI: 1.29-4.80) acted as risk factors for having higher levels of psychological distress among the students. The most common coping activity reported was spending more time on social media platforms (n = 269, 70.6%), and 209 students (54.9%) reported distance learning as their most distressing concern.\r\n\r\nThe COVID-19 pandemic and related control measures could impact the mental health of individuals, including students. We recommend a nationwide psychological support program to be incorporated into Jordan's preparedness plan and response strategy in combating the COVID-19 pandemic.", "doi": "10.3389/fpsyg.2020.562213", "pmid": "33240151", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-11-27T10:26:56.700Z", "modified": "2022-11-09T08:26:17.199Z"}, {"entity": "publication", "iuid": "f7f7b25eb9d046b4baf27e0470dc9510", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7f7b25eb9d046b4baf27e0470dc9510.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7f7b25eb9d046b4baf27e0470dc9510"}}, "title": "COVID-19: Nanomedicine Uncovers Blood-Clot Mystery.", "authors": [{"family": "Saei", "given": "Amir Ata", "initials": "AA"}, {"family": "Sharifi", "given": "Shahriar", "initials": "S"}, {"family": "Mahmoudi", "given": "Morteza", "initials": "M"}], "type": "journal article", "published": "2020-11-06", "journal": {"title": "J Proteome Res", "issn": "1535-3907", "volume": "19", "issue": "11", "pages": "4364-4373", "issn-l": null}, "abstract": "Further complications associated with infection by severe acute respiratory syndrome coronavirus 2 (a.k.a. SARS-CoV-2) continue to be reported. Very recent findings reveal that 20-30% of patients at high risk of mortality from COVID-19 infection experience blood clotting that leads to stroke and sudden death. Timely assessment of the severity of blood clotting will be of enormous help to clinicians in determining the right blood-thinning medications to prevent stroke or other life-threatening consequences. Therefore, rapid identification of blood-clotting-related proteins in the plasma of COVID-19 patients would save many lives. Several nanotechnology-based approaches are being developed to diagnose patients at high risk of death due to complications from COVID-19 infections, including blood clots. This Perspective outlines (i) the significant potential of nanomedicine in assessing the risk of blood clotting and its severity in SARS-CoV-2 infected patients and (ii) its synergistic roles with advanced mass-spectrometry-based proteomics approaches in identifying the important protein patterns that are involved in the occurrence and progression of this disease. The combination of such powerful tools might help us understand the clotting phenomenon and pave the way for development of new diagnostics and therapeutics in the fight against COVID-19.", "doi": "10.1021/acs.jproteome.0c00425", "pmid": "32790309", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7640964"}], "notes": [], "created": "2020-12-07T13:26:03.336Z", "modified": "2020-12-07T13:26:03.347Z"}, {"entity": "publication", "iuid": "facb78b4ec404e50a6986cb53cf8a3ec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/facb78b4ec404e50a6986cb53cf8a3ec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/facb78b4ec404e50a6986cb53cf8a3ec"}}, "title": "Searching for target-specific and multi-targeting organics for Covid-19 in the Drugbank database with a double scoring approach.", "authors": [{"family": "Murugan", "given": "Natarajan Arul", "initials": "NA"}, {"family": "Kumar", "given": "Sanjiv", "initials": "S"}, {"family": "Jeyakanthan", "given": "Jeyaraman", "initials": "J"}, {"family": "Srivastava", "given": "Vaibhav", "initials": "V"}], "type": "journal article", "published": "2020-11-05", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "10", "issue": "1", "pages": "19125"}, "abstract": "The current outbreak of Covid-19 infection due to SARS-CoV-2, a virus from the coronavirus family, has become a major threat to human healthcare. The virus has already infected more than 44 M people and the number of deaths reported has reached more than 1.1 M which may be attributed to lack of medicine. The traditional drug discovery approach involves many years of rigorous research and development and demands for a huge investment which cannot be adopted for the ongoing pandemic infection. Rather we need a swift and cost-effective approach to inhibit and control the viral infection. With the help of computational screening approaches and by choosing appropriate chemical space, it is possible to identify lead drug-like compounds for Covid-19. In this study, we have used the Drugbank database to screen compounds against the most important viral targets namely 3C-like protease (3CLpro), papain-like protease (PLpro), RNA-dependent RNA polymerase (RdRp) and the spike (S) protein. These targets play a major role in the replication/transcription and host cell recognition, therefore, are vital for the viral reproduction and spread of infection. As the structure based computational screening approaches are more reliable, we used the crystal structures for 3C-like main protease and spike protein. For the remaining targets, we used the structures based on homology modeling. Further, we employed two scoring methods based on binding free energies implemented in AutoDock Vina and molecular mechanics-generalized Born surface area approach. Based on these results, we propose drug cocktails active against the three viral targets namely 3CLpro, PLpro and RdRp. Interestingly, one of the identified compounds in this study i.e. Baloxavir marboxil has been under clinical trial for the treatment of Covid-19 infection. In addition, we have identified a few compounds such as Phthalocyanine, Tadalafil, Lonafarnib, Nilotinib, Dihydroergotamine, R-428 which can bind to all three targets simultaneously and can serve as multi-targeting drugs. Our study also included calculation of binding energies for various compounds currently under drug trials. Among these compounds, it is found that Remdesivir binds to targets, 3CLpro and RdRp with high binding affinity. Moreover, Baricitinib and Umifenovir were found to have superior target-specific binding while Darunavir is found to be a potential multi-targeting drug. As far as we know this is the first study where the compounds from the Drugbank database are screened against four vital targets of SARS-CoV-2 and illustrates that the computational screening using a double scoring approach can yield potential drug-like compounds against Covid-19 infection.", "doi": "10.1038/s41598-020-75762-7", "pmid": "33154404", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-020-75762-7"}, {"db": "pmc", "key": "PMC7645721"}], "notes": [], "created": "2020-12-01T14:46:02.174Z", "modified": "2021-02-26T08:45:25.943Z"}, {"entity": "publication", "iuid": "751306da9bde4244b9913b6fd059cf8d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/751306da9bde4244b9913b6fd059cf8d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/751306da9bde4244b9913b6fd059cf8d"}}, "title": "Hospital preparedness challenges in biological disasters: A qualitative study.", "authors": [{"family": "Aminizadeh", "given": "Mohsen", "initials": "M"}, {"family": "Farrokhi", "given": "Mehrdad", "initials": "M"}, {"family": "Ebadi", "given": "Abbas", "initials": "A"}, {"family": "Masoumi", "given": "Gholam Reza", "initials": "GR"}, {"family": "Kolivand", "given": "Pirhossein", "initials": "P"}, {"family": "Khankeh", "given": "Hamid Reza", "initials": "HR"}], "type": "journal article", "published": "2020-11-05", "journal": {"title": "Disaster Med Public Health Prep", "issn": "1938-744X", "issn-l": "1935-7893", "volume": null, "issue": null, "pages": "1-13"}, "abstract": "Identification of hospital preparedness challenges against biological events such as COVID-19 is essential to improve dynamics, quality and business continuity confidence in the health system. Accordingly, the purpose of the present study is to evaluate the challenges of hospital preparedness in biological events.\r\n\r\nThis study employed a qualitative method using content analysis in which 20 healthcare managers and experts who are experienced in biological events were selected through purposeful sampling. The data collection was done through semi-structured interviews, which continued until data saturation. The data were analyzed using qualitative content analysis as well as the Landman and Graneheim Approach.\r\n\r\nSix main concepts (training and practice, resource management, safety and health, patient management, risk communication, and laboratory and surveillance) and 14 sub-concepts were extracted on hospital preparedness challenges in biological events through analyzing interviews.\r\n\r\nThe present study indicated that the health system of the country faces many challenges in response to biological events and threats. Moreover, study participants indicated that Iranian hospitals were not prepared for biological events. It is recommended to design preparedness plans of hospitals based on preparedness standards for biological events. In addition, comprehensive measures are required to enhance their capacity to respond to biological emergencies.", "doi": "10.1017/dmp.2020.434", "pmid": "33148363", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1935789320004346"}], "notes": [], "created": "2020-11-27T10:13:26.533Z", "modified": "2022-11-09T08:27:25.836Z"}, {"entity": "publication", "iuid": "d5b3f3d7bcd049fea392cd3db33852a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5b3f3d7bcd049fea392cd3db33852a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5b3f3d7bcd049fea392cd3db33852a2"}}, "title": "Effect and safety of Chinese herbal medicine granules in patients with severe coronavirus disease 2019 in Wuhan, China: a retrospective, single-center study with propensity score matching.", "authors": [{"family": "Wang", "given": "Yuanyuan", "initials": "Y"}, {"family": "Liu", "given": "Yuntao", "initials": "Y"}, {"family": "Lv", "given": "Qingquan", "initials": "Q"}, {"family": "Zheng", "given": "Danwen", "initials": "D"}, {"family": "Zhou", "given": "Li", "initials": "L"}, {"family": "Ouyang", "given": "Wenwei", "initials": "W"}, {"family": "Ding", "given": "Banghan", "initials": "B"}, {"family": "Zou", "given": "Xu", "initials": "X"}, {"family": "Yan", "given": "Fang", "initials": "F"}, {"family": "Liu", "given": "Bo", "initials": "B"}, {"family": "Chen", "given": "Jun", "initials": "J"}, {"family": "Liu", "given": "Tianzhu", "initials": "T"}, {"family": "Fu", "given": "Chicheng", "initials": "C"}, {"family": "Fang", "given": "Qu", "initials": "Q"}, {"family": "Wang", "given": "Yi", "initials": "Y"}, {"family": "Li", "given": "Fang", "initials": "F"}, {"family": "Chen", "given": "Ailan", "initials": "A"}, {"family": "Lundborg", "given": "Cecilia St\u00e5lsby", "initials": "CS"}, {"family": "Guo", "given": "Jianwen", "initials": "J"}, {"family": "Wen", "given": "Zehuai", "initials": "Z"}, {"family": "Zhang", "given": "Zhongde", "initials": "Z"}], "type": "journal article", "published": "2020-11-05", "journal": {"title": "Phytomedicine", "issn": "1618-095X", "volume": null, "issue": null, "pages": "153404", "issn-l": "0944-7113"}, "abstract": "Chinese herbal medicine (CHM) has been used for severe illness caused by coronavirus disease 2019 (COVID-19), but its treatment effects and safety are unclear.\n\nThis study reviews the effect and safety of CHM granules in the treatment of patients with severe COVID-19.\n\nWe conducteda single-center, retrospective study on patients with severe COVID-19 in a designated hospital in Wuhan from January 15, 2020 to March 30, 2020. The propensity score matching (PSM) was used to assess the effect and safety of the treatment using CHM granules. The ratio of patients who received treatment with CHM granules combined with usual care and those who received usual care alone was 1:1. The primary outcome was the time to clinical improvement within 28 days, defined as the time taken for the patients' health to show improvement by decline of two categories (from the baseline) on a modified six-category ordinal scale, or to be dischargedfrom the hospital before Day 28.\n\nUsing PSM, 43 patients (45% male) aged 65.6 (57-70) yearsfrom each group were exactly matched. No significant difference was observed in clinical improvement of patients treated with CHM granules compared with those who received usual (p = 0.851). However, the use of CHM granules reduced the 28-day mortality (p = 0.049) and shortened the duration of fever (4 days vs. 7 days, p = 0.002). The differences in the duration of cough and dyspnea and the difference in lung lesion ratio on computerized tomography scans were not significant.Commonly,patients in the CHM group had an increased D-dimer level (p = 0.036).\n\nForpatients with severe COVID-19, CHM granules, combined with usual care, showed no improvement beyond usual care alone. However, the use of CHM granules reduced the 28-day mortality rate and the time to fever alleviation. Nevertheless, CHM granules may be associated with high risk of fibrinolysis.", "doi": "10.1016/j.phymed.2020.153404", "pmid": "33637412", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0944-7113(20)30235-X"}], "notes": [], "created": "2021-03-01T10:28:51.462Z", "modified": "2021-03-01T10:28:51.473Z"}, {"entity": "publication", "iuid": "cd7cc72539de42339a8adea9f3ffbed2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd7cc72539de42339a8adea9f3ffbed2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd7cc72539de42339a8adea9f3ffbed2"}}, "title": "Differences of SARS-CoV-2 serological test performance between hospitalized and outpatient COVID-19 cases.", "authors": [{"family": "Wolf", "given": "Johannes", "initials": "J"}, {"family": "Kaiser", "given": "Thorsten", "initials": "T"}, {"family": "Pehnke", "given": "Sarah", "initials": "S"}, {"family": "Nickel", "given": "Olaf", "initials": "O"}, {"family": "L\u00fcbbert", "given": "Christoph", "initials": "C"}, {"family": "Kalbitz", "given": "Sven", "initials": "S"}, {"family": "Arnold", "given": "Benjamin", "initials": "B"}, {"family": "Ermisch", "given": "J\u00f6rg", "initials": "J"}, {"family": "Berger", "given": "Luisa", "initials": "L"}, {"family": "Schroth", "given": "Stefanie", "initials": "S"}, {"family": "Isermann", "given": "Berend", "initials": "B"}, {"family": "Borte", "given": "Stephan", "initials": "S"}, {"family": "Biemann", "given": "Ronald", "initials": "R"}], "type": "journal article", "published": "2020-11-05", "journal": {"title": "Clin Chim Acta", "issn": "1873-3492", "volume": null, "issue": null, "issn-l": "0009-8981"}, "abstract": "Serological severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody assays differ in the target antigen specificity, e.g. of antibodies directed against the viral spike or the nucleocapsid protein, and in the spectrum of detected immunoglobulins. The aim of the study was to evaluate the performance of two different routinely used immunoassays in hospitalized and outpatient COVID-19 cases.\n\nThe test characteristics of commercially available spike1 protein-based serological assays (Euroimmun, EI-assays), determining IgA or IgG and nucleocapsid-based assays (Virotech, VT-assays) determining IgA, IgM or IgG were compared in 139 controls and 116 hospitalized and outpatient COVID-19 cases.\n\nHospitalized COVID-19 patients (n = 51; 115 samples) showed significantly higher concentrations of antibodies against SARS-CoV-2 and differed from outpatient cases (n = 65) by higher age, higher disease severity scores and earlier follow up blood sampling. Sensitivity of the two IgG assays was comparable in hospitalized patients tested \u2265 14 days (EI-assay: 88%, CI 95% 67.6-99.9; VT-assay: 96%, CI95% 77.7-99.8). In outpatient COVID-19 cases sensitivity was significantly lower in the VT-assay (86.2%, CI95% 74.8-93.1) compared with the EI-assay (98.5%, CI95% 90.6-99.9). Assays for IgA and IgM demonstrated a lack of specificity or sensitivity.\n\nOur results indicate that SARS-CoV-2 serological assays may need to be optimized to produce reliable results in outpatient COVID-19 cases who are low or even asymptomatic. Assays for IgA and IgM have limited diagnostic performance and do not prove an additional value for population-based screening approaches.", "doi": "10.1016/j.cca.2020.10.035", "pmid": "33159952", "labels": {"Type: Journal article": null, "Category: Serology": null}, "xrefs": [{"db": "pii", "key": "S0009-8981(20)30517-9"}, {"db": "pmc", "key": "PMC7642750"}], "notes": [], "created": "2020-11-27T10:07:09.483Z", "modified": "2021-02-26T08:46:49.385Z"}, {"entity": "publication", "iuid": "0415d3631d304d8fbf5b049b0b57dc4f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0415d3631d304d8fbf5b049b0b57dc4f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0415d3631d304d8fbf5b049b0b57dc4f"}}, "title": "Changes in Tinnitus Experiences During the COVID-19 Pandemic.", "authors": [{"family": "Beukes", "given": "Eldr\u00e9 W", "initials": "EW"}, {"family": "Baguley", "given": "David M", "initials": "DM"}, {"family": "Jacquemin", "given": "Laure", "initials": "L"}, {"family": "Lourenco", "given": "Matheus P C G", "initials": "MPCG"}, {"family": "Allen", "given": "Peter M", "initials": "PM"}, {"family": "Onozuka", "given": "Joy", "initials": "J"}, {"family": "Stockdale", "given": "David", "initials": "D"}, {"family": "Kaldo", "given": "Viktor", "initials": "V"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Manchaiah", "given": "Vinaya", "initials": "V"}], "type": "journal article", "published": "2020-11-05", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "592878", "issn-l": "2296-2565"}, "abstract": "Introduction: The COVID-19 pandemic has disrupted delivery of healthcare, economic activity, and affected social interactions. Identifying and supporting those most affected by the pandemic is required. The purpose of this study was to determine the impact of the pandemic on individuals with tinnitus and to identify mediating factors. Methods: This is a mixed-methods exploratory cross-sectional study, using data collected via an online survey from 3,103 individuals with tinnitus from 48 countries. The greatest representation was from North America (49%) and Europe (47%) and other countries were only marginally represented. Results: Although the study was aimed at those with pre-existing tinnitus, 7 individuals reported having COVID-19 initiated tinnitus. Having COVID-19 symptoms exacerbated tinnitus in 40% of respondents, made no change in 54%, and improved tinnitus in 6%. Other mediating factors such as the social and emotional consequences of the pandemic made pre-existing tinnitus more bothersome for 32% of the respondents, particularly for females and younger adults, better for 1%, and caused no change to tinnitus for 67%. Pre-existing tinnitus was significantly exacerbated for those self-isolating, experiencing loneliness, sleeping poorly, and with reduced levels of exercise. Increased depression, anxiety, irritability, and financial worries further significantly contributed to tinnitus being more bothersome during the pandemic period. Conclusions: These findings have implications for tinnitus management, because they highlight the diverse response both internal and external factors have on tinnitus levels. Clinical services should be mindful that tinnitus may be caused by contracting COVID-19 and pre-existing tinnitus may be exacerbated, although in the majority of respondents there was no change. Additional support should be offered where tinnitus severity has increased due to the health, social, and/or emotional effects of the COVID-19 pandemic. Tinnitus may be more bothersome for those experiencing loneliness, having fewer social interactions, and who are more anxious or worried.", "doi": "10.3389/fpubh.2020.592878", "pmid": "33251179", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7676491"}], "notes": [], "created": "2020-12-03T08:25:37.374Z", "modified": "2021-02-26T08:45:47.798Z"}, {"entity": "publication", "iuid": "8b254ae76f9b47aabd6eea4864698cc3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b254ae76f9b47aabd6eea4864698cc3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b254ae76f9b47aabd6eea4864698cc3"}}, "title": "COVID-19 and misinformation: Is censorship of social media a remedy to the spread of medical misinformation?", "authors": [{"family": "Niemiec", "given": "Emilia", "initials": "E"}], "type": "journal article", "published": "2020-11-05", "journal": {"title": "EMBO Rep", "issn": "1469-3178", "volume": "21", "issue": "11", "pages": "e51420", "issn-l": null}, "abstract": "Social media companies have resorted to censorship to suppress misinformation about the COVID-19 pandemic. This is not the most prudent solution though given the uncertainties about the disease.", "doi": "10.15252/embr.202051420", "pmid": "33103289", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7645258"}], "notes": [], "created": "2020-12-01T15:26:00.457Z", "modified": "2020-12-01T15:26:15.906Z"}, {"entity": "publication", "iuid": "2caee507b4b1417aaf5e5dde8f795031", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2caee507b4b1417aaf5e5dde8f795031.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2caee507b4b1417aaf5e5dde8f795031"}}, "title": "The impact of the early phase of the COVID-19 pandemic on mental-health services in Europe.", "authors": [{"family": "Thome", "given": "Johannes", "initials": "J"}, {"family": "Deloyer", "given": "Jocelyn", "initials": "J"}, {"family": "Coogan", "given": "Andrew N", "initials": "AN"}, {"family": "Bailey-Rodriguez", "given": "Deborah", "initials": "D"}, {"family": "da Cruz E Silva", "given": "Odete A B", "initials": "OAB"}, {"family": "Faltraco", "given": "Frank", "initials": "F"}, {"family": "Grima", "given": "Cathleen", "initials": "C"}, {"family": "Gudjonsson", "given": "Snaebjorn Omar", "initials": "SO"}, {"family": "Hanon", "given": "Cecile", "initials": "C"}, {"family": "Holl\u00fd", "given": "Martin", "initials": "M"}, {"family": "Joosten", "given": "Jo", "initials": "J"}, {"family": "Karlsson", "given": "Ingegerd", "initials": "I"}, {"family": "Kelemen", "given": "Gabriela", "initials": "G"}, {"family": "Korman", "given": "Maria", "initials": "M"}, {"family": "Krysta", "given": "Krzysztof", "initials": "K"}, {"family": "Lichterman", "given": "Boleslav", "initials": "B"}, {"family": "Loganovsky", "given": "Konstantin", "initials": "K"}, {"family": "Marazziti", "given": "Donatella", "initials": "D"}, {"family": "Maraitou", "given": "Margarita", "initials": "M"}, {"family": "Mertens de Wilmars", "given": "Serge", "initials": "S"}, {"family": "Reunamen", "given": "Merja", "initials": "M"}, {"family": "Rexhaj", "given": "Shyhrete", "initials": "S"}, {"family": "Sancaktar", "given": "Muhammet", "initials": "M"}, {"family": "Sempere", "given": "Javier", "initials": "J"}, {"family": "Tournier", "given": "Isabelle", "initials": "I"}, {"family": "Weynant", "given": "Emilie", "initials": "E"}, {"family": "Vis", "given": "Christiaan", "initials": "C"}, {"family": "Lebas", "given": "Marie-Clotilde", "initials": "MC"}, {"family": "Fond-Harmant", "given": "Laurence", "initials": "L"}], "type": "journal article", "published": "2020-11-04", "journal": {"title": "World J Biol Psychiatry", "issn": "1814-1412", "volume": null, "issue": null, "pages": "1-15", "issn-l": null}, "abstract": "The current COVID-19 pandemic confronts psychiatric patients and mental health services with unique and severe challenges. In order to identify these trans-national challenges across Europe, an ad-hoc survey was conducted among 23 experts, each answering for one European or aligned country. A number of important themes and issues were raised for the impact of COVID-19 on mental health and mental health services, barriers to service provision and future consequences. A number of key issues were reported by colleagues across several jurisdictions, even though these were at different stages of their national epidemics. Based on these findings, we articulate some important learnings from the early stages of the COVID-19 European pandemic, and highlight key considerations for all countries' mental health services as the current pandemic develops and for future pandemics.", "doi": "10.1080/15622975.2020.1844290", "pmid": "33143529", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-01T14:50:54.093Z", "modified": "2020-12-01T14:50:54.114Z"}, {"entity": "publication", "iuid": "708edd457cd5407da90e7a672b55b849", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/708edd457cd5407da90e7a672b55b849.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/708edd457cd5407da90e7a672b55b849"}}, "title": "Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2", "authors": [{"family": "Cust\u00f3dio", "given": "T\u00e2nia F", "initials": "TF"}, {"family": "Das", "given": "Hrishikesh", "initials": "H"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Pazicky", "given": "Samuel", "initials": "S"}, {"family": "Pieprzyk", "given": "Joanna", "initials": "J"}, {"family": "Sorgenfrei", "given": "Mich\u00e8le", "initials": "M"}, {"family": "Schroer", "given": "Martin A", "initials": "MA"}, {"family": "Gruzinov", "given": "Andrey Yu", "initials": "AY"}, {"family": "Jeffries", "given": "Cy M", "initials": "CM"}, {"family": "Graewert", "given": "Melissa A", "initials": "MA"}, {"family": "Svergun", "given": "Dmitri I", "initials": "DI"}, {"family": "Dobrev", "given": "Nikolay", "initials": "N"}, {"family": "Remans", "given": "Kim", "initials": "K"}, {"family": "Seeger", "given": "Markus A", "initials": "MA"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "H\u00e4llberg", "given": "B Martin", "initials": "BM"}, {"family": "L\u00f6w", "given": "Christian", "initials": "C"}], "type": "journal-article", "published": "2020-11-04", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "11", "issue": "1", "pages": null}, "abstract": "The coronavirus SARS-CoV-2 is the cause of the ongoing COVID-19 pandemic. Therapeutic neutralizing antibodies constitute a key short-to-medium term approach to tackle COVID-19. However, traditional antibody production is hampered by long development times and costly production. Here, we report the rapid isolation and characterization of nanobodies from a synthetic library, known as sybodies (Sb), that target the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein. Several binders with low nanomolar affinities and efficient neutralization activity were identified of which Sb23 displayed high affinity and neutralized pseudovirus with an IC50 of 0.6\u2009\u00b5g/ml. A cryo-EM structure of the spike bound to Sb23 showed that Sb23 binds competitively in the ACE2 binding site. Furthermore, the cryo-EM reconstruction revealed an unusual conformation of the spike where two RBDs are in the \u2018up\u2019 ACE2-binding conformation. The combined approach represents an alternative, fast workflow to select binders with neutralizing activity against newly emerging viruses.", "doi": "10.1038/s41467-020-19204-y", "pmid": "33149112", "labels": {"Type: Journal article": null, "Funder: VR": null, "Research Area: Host cell systems biology and targets": null, "Funder: H2020": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Category: Other": null, "Category: Proteins": null}, "xrefs": [{"db": "URL", "key": "https://github.com/tania-custodio/Sb23", "description": "Github: MST and BLI data"}, {"db": "URL", "key": "https://www.sasbdb.org/data/SASDJF4/", "description": "SASBDB SASDJF4: Synthetic nanobody Sybody 23 (Sy23)"}, {"db": "URL", "key": "https://www.sasbdb.org/data/SASDJG4/", "description": "SASBDB SASDJG4: SARS-CoV-2 spike protein ACE2 receptor binding domain (RBD)"}, {"db": "URL", "key": "https://www.sasbdb.org/data/SASDJH4/", "description": "SASBDB SASDJH4: SARS-CoV-2 spike protein ACE2 receptor binding domain (RBD) bound to the synthetic nanobody Sybody 23 (Sy23)"}, {"db": "PDB", "key": "7A25", "description": "Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing sybodies (Sb23) (1-up)"}, {"db": "PDB", "key": "7A29", "description": "Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing sybodies (Sb23) (2-up)"}, {"db": "URL", "key": "https://www.ebi.ac.uk/pdbe/entry/emdb/EMD-11617", "description": "EMDB EMD-11617: Cryo-EM density maps of SARS-CoV-2 spike glycoprotein with Sb23 bound (2-up)"}, {"db": "URL", "key": "https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-020-19204-y/MediaObjects/41467_2020_19204_MOESM4_ESM.pdf", "description": "Sequences of all the selected sybodies from the study"}], "notes": [], "created": "2020-11-10T10:40:14.648Z", "modified": "2021-06-13T14:17:49.316Z"}, {"entity": "publication", "iuid": "ab683807584e43508e269e9580f7d3ac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ab683807584e43508e269e9580f7d3ac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ab683807584e43508e269e9580f7d3ac"}}, "title": "Innate lymphoid cell composition associates with COVID-19 disease severity", "authors": [{"family": "Garc\u00eda", "given": "Marina", "initials": "M"}, {"family": "Kokkinou", "given": "Efthymia", "initials": "E"}, {"family": "Carrasco Garc\u00eda", "given": "Anna", "initials": "A"}, {"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Palma Medina", "given": "Laura M.", "initials": "LM"}, {"family": "Maleki", "given": "Kimia T.", "initials": "KT"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Varnait\u0117", "given": "Renata", "initials": "R"}, {"family": "Filipovic", "given": "Iva", "initials": "I"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K.", "initials": "NK"}, {"family": "Folkesson", "given": "Elin", "initials": "E"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Eriksson", "given": "Lars I.", "initials": "LI"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J"}, {"family": "Group", "given": "the Karolinska KI/K COVID-19 Study", "initials": "tKKCS"}], "type": "posted-content", "published": "2020-11-04", "journal": {"title": "Clin Transl Immunol", "issn": "2050-0068", "issn-l": null, "volume": "9", "issue": "12", "pages": null}, "abstract": "Objectives The role of innate lymphoid cells (ILCs) in coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is unknown. Understanding the immune response in COVID-19 could contribute to unravel the pathogenesis and identification of treatment targets. To describe the phenotypic landscape of circulating ILCs in COVID-19 patients and to identify ILC phenotypes correlated to serum biomarkers, clinical markers, and laboratory parameters relevant in COVID-19.\r\n\r\nMethods Blood samples collected from moderately (n=11) and severely ill (n=12) COVID-19 patients as well as healthy control donors (n=16), were analyzed with 18-parameter flow cytometry. Using supervised and unsupervised approaches, we examined the ILC activation status and homing profile. Clinical and laboratory parameters were obtained from all COVID-19 patients and serum biomarkers were analyzed with multiplex immunoassays.\r\n\r\nResults ILCs were largely depleted from the circulation of COVID-19 patients compared with healthy controls. Remaining circulating ILCs from patients revealed increased frequencies of ILC2 in moderate COVID-19, with a concomitant decrease of ILC precursors (ILCp), as compared with controls. ILC2 and ILCp showed an activated phenotype with increased CD69 expression, whereas expression levels of the chemokine receptors CXCR3 and CCR4 were significantly altered in ILC2 and ILCp, and ILC1, respectively. The activated ILC profile of COVID-19 patients was associated with soluble inflammatory markers, while frequencies of ILC subsets were correlated with laboratory parameters that reflect the disease severity.\r\n\r\nConclusion This study provides insights into the potential role of ILCs in immune responses against SARS-CoV-2, particularly linked to the severity of COVID-19.", "doi": "10.1002/cti2.1224", "pmid": "33343897", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://covid19cellatlas.com/#/", "description": "Karolinska KI/K Covid19 Immune atlas"}], "notes": [], "created": "2020-11-04T14:24:06.108Z", "modified": "2021-06-13T14:18:39.784Z"}, {"entity": "publication", "iuid": "2ba162b83ed44bdcb5738acf41b3156e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ba162b83ed44bdcb5738acf41b3156e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ba162b83ed44bdcb5738acf41b3156e"}}, "title": "Global between-countries variance in SARS-CoV-2 mortality is driven by reported prevalence, age distribution, and case detection rate", "authors": [{"family": "Baba\u010di\u0107", "given": "Haris", "initials": "H"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J"}, {"family": "Pernemalm", "given": "Maria", "initials": "M"}], "type": null, "published": "2020-11-04", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Objective: To explain the global between-countries variance in number of deaths per million citizens (nDpm) and case fatality rate (CFR) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Design: Systematic analysis. Data sources: Worldometer, European Centre for Disease Prevention and Control, United Nations Main outcome measures: The explanators of nDpm and CFR were mathematically hypothesised and tested on publicly-available data from 88 countries with linear regression models on May 1st 2020. The derived explanators - age-adjusted infection fatality rate (IFRadj) and case detection rate (CDR) - were estimated for each country based on a SARS-CoV-2 model of China. The accuracy and agreement of the models with observed data was assessed with R2 and Bland-Altman plots, respectively. Sensitivity analyses involved removal of outliers and testing the models at five retrospective and two prospective time points. Results: Globally, IFRadj estimates varied between countries, ranging from below 0.2% in the youngest nations, to above 1.3% in Portugal, Greece, Italy, and Japan. The median estimated global CDR of SARS-CoV-2 infections on April 16th 2020 was 12.9%, suggesting that most of the countries have a much higher number of cases than reported. At least 93% and up to 99% of the variance in nDpm was explained by reported prevalence expressed as cases per million citizens (nCpm), IFRadj, and CDR. IFRadj and CDR accounted for up to 97% of the variance in CFR, but this model was less reliable than the nDpm model, being sensitive to outliers (R2 as low as 67.5%). Conclusions: The current differences in SARS-CoV-2 mortality between countries are driven mainly by reported prevalence of infections, age distribution, and CDR. The nDpm might be a more stable estimate than CFR in comparing mortality burden between countries.", "doi": "10.1101/2020.05.28.20114934", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-04T15:42:54.004Z", "modified": "2021-02-26T08:45:47.974Z"}, {"entity": "publication", "iuid": "7a93d531baf34f3cbe335fcb17e935f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a93d531baf34f3cbe335fcb17e935f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a93d531baf34f3cbe335fcb17e935f8"}}, "title": "Circulating bioactive adrenomedullin as a marker of sepsis, septic shock and critical illness.", "authors": [{"family": "Lundberg", "given": "Oscar H M", "initials": "OHM"}, {"family": "Lengquist", "given": "Maria", "initials": "M"}, {"family": "Sp\u00e5ngfors", "given": "Martin", "initials": "M"}, {"family": "Annborn", "given": "Martin", "initials": "M"}, {"family": "Bergmann", "given": "Deborah", "initials": "D"}, {"family": "Schulte", "given": "Janin", "initials": "J"}, {"family": "Levin", "given": "Helena", "initials": "H"}, {"family": "Melander", "given": "Olle", "initials": "O"}, {"family": "Frigyesi", "given": "Attila", "initials": "A"}, {"family": "Friberg", "given": "Hans", "initials": "H"}], "type": "journal article", "published": "2020-11-04", "journal": {"title": "Crit Care", "issn": "1466-609X", "volume": "24", "issue": "1", "pages": "636", "issn-l": "1364-8535"}, "abstract": "Biomarkers can be of help to understand critical illness and to identify and stratify sepsis. Adrenomedullin is a vasoactive hormone, with reported prognostic and potentially therapeutic value in sepsis. The primary aim of this study was to investigate the association of circulating bioactive adrenomedullin (bio-ADM) levels at intensive care unit (ICU) admission with mortality in sepsis patients and in a general ICU population. Secondary aims included the association of bio-ADM with organ failure and the ability of bio-ADM to identify sepsis.\n\nIn this retrospective observational study, adult patients admitted to one of four ICUs during 2016 had admission bio-ADM levels analysed. Age-adjusted odds ratios (OR) with 95% CI for log-2 transformed bio-ADM, and Youden's index derived cut-offs were calculated. The primary outcome was 30-day mortality, and secondary outcomes included the need for organ support and the ability to identify sepsis.\n\nBio-ADM in 1867 consecutive patients were analysed; 632 patients fulfilled the sepsis-3 criteria of whom 267 had septic shock. The median bio-ADM in the entire ICU population was 40 pg/mL, 74 pg/mL in sepsis patients, 107 pg/mL in septic shock and 29 pg/mL in non-septic patients. The association of elevated bio-ADM and mortality in sepsis patients and the ICU population resulted in ORs of 1.23 (95% CI 1.07-1.41) and 1.22 (95% CI 1.12-1.32), respectively. The association with mortality remained after additional adjustment for lactate in sepsis patients. Elevated bio-ADM was associated with an increased need for dialysis with ORs of 2.28 (95% CI 2.01-2.59) and 1.97 (95% CI 1.64-2.36) for the ICU population and sepsis patients, respectively, and with increased need of vasopressors, OR 1.33 (95% CI 1.23-1.42) (95% CI 1.17-1.50) for both populations. Sepsis was identified with an OR of 1.78 (95% CI 1.64-1.94) for bio-ADM, after additional adjustment for severity of disease. A bio-ADM cut-off of 70 pg/mL differentiated between survivors and non-survivors in sepsis, but a Youden's index derived threshold of 108 pg/mL performed better.\n\nAdmission bio-ADM is associated with 30-day mortality and organ failure in sepsis patients as well as in a general ICU population. Bio-ADM may be a morbidity-independent sepsis biomarker.", "doi": "10.1186/s13054-020-03351-1", "pmid": "33148300", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7641835"}, {"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-12-02T18:20:01.327Z", "modified": "2021-02-26T08:45:48.358Z"}, {"entity": "publication", "iuid": "8cc0ac83572f4f3a9281eda66d0746a5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8cc0ac83572f4f3a9281eda66d0746a5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8cc0ac83572f4f3a9281eda66d0746a5"}}, "title": "Associations between mortality from COVID-19 in two Italian regions and outdoor air pollution as assessed through tropospheric nitrogen dioxide.", "authors": [{"family": "Filippini", "given": "Tommaso", "initials": "T"}, {"family": "Rothman", "given": "Kenneth J", "initials": "KJ"}, {"family": "Cocchio", "given": "Silvia", "initials": "S"}, {"family": "Narne", "given": "Elena", "initials": "E"}, {"family": "Mantoan", "given": "Domenico", "initials": "D"}, {"family": "Saia", "given": "Mario", "initials": "M"}, {"family": "Goffi", "given": "Alessia", "initials": "A"}, {"family": "Ferrari", "given": "Fabrizio", "initials": "F"}, {"family": "Maffeis", "given": "Giuseppe", "initials": "G"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}, {"family": "Baldo", "given": "Vincenzo", "initials": "V"}, {"family": "Vinceti", "given": "Marco", "initials": "M"}], "type": "journal article", "published": "2020-11-04", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "volume": "760", "issue": null, "pages": "143355", "issn-l": "0048-9697"}, "abstract": "After the appearance of COVID-19 in China last December 2019, Italy was the first European country to be severely affected by the outbreak. The first diagnosis in Italy was on February 20, 2020, followed by the establishment of a light and a tight lockdown on February 23 and on March 8, 2020, respectively. The virus spread rapidly, particularly in the North of the country in the 'Padan Plain' area, known as one of the most polluted regions in Europe. Air pollution has been recently hypothesized to enhance the clinical severity of SARS-CoV-2 infection, acting through adverse effects on immunity, induction of respiratory and other chronic disease, upregulation of viral receptor ACE-2, and possible pathogen transportation as a virus carrier. We investigated the association between air pollution and subsequent COVID-19 mortality rates within two Italian regions (Veneto and Emilia-Romagna). We estimated ground-level nitrogen dioxide through its tropospheric levels using data available from the Sentinel-5P satellites of the European Space Agency Copernicus Earth Observation Programme before the lockdown. We then examined COVID-19 mortality rates in relation to the nitrogen dioxide levels at three 14-day lag points after the lockdown, namely March 8, 22 and April 5, 2020. Using a multivariable negative binomial regression model, we found an association between nitrogen dioxide and COVID-19 mortality. Although ecological data provide only weak evidence, these findings indicate an association between air pollution levels and COVID-19 severity.", "doi": "10.1016/j.scitotenv.2020.143355", "pmid": "33187703", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(20)36886-8"}, {"db": "pmc", "key": "PMC7609227"}], "notes": [], "created": "2020-11-27T09:58:18.493Z", "modified": "2021-02-26T08:46:13.371Z"}, {"entity": "publication", "iuid": "16e615de9a304cc385f80806c47bc1fe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16e615de9a304cc385f80806c47bc1fe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16e615de9a304cc385f80806c47bc1fe"}}, "title": "Decision-making around admission to intensive care in the UK pre-COVID-19: a multicentre ethnographic study.", "authors": [{"family": "Griffiths", "given": "F", "initials": "F"}, {"family": "Svantesson", "given": "M", "initials": "M"}, {"family": "Bassford", "given": "C", "initials": "C"}, {"family": "Dale", "given": "J", "initials": "J"}, {"family": "Blake", "given": "C", "initials": "C"}, {"family": "McCreedy", "given": "A", "initials": "A"}, {"family": "Slowther", "given": "A-M", "initials": "AM"}], "type": "journal article", "published": "2020-11-03", "journal": {"title": "Anaesthesia", "issn": "1365-2044", "volume": null, "issue": null, "issn-l": "0003-2409"}, "abstract": "Predicting who will benefit from admission to an intensive care unit is not straightforward and admission processes vary. Our aim was to understand how decisions to admit or not are made. We observed 55 decision-making events in six NHS hospitals. We interviewed 30 referring and 43 intensive care doctors about these events. We describe the nature and context of the decision-making and analysed how doctors make intensive care admission decisions. Such decisions are complex with intrinsic uncertainty, often urgent and made with incomplete information. While doctors aspire to make patient-centred decisions, key challenges include: being overworked with lack of time; limited support from senior staff; and a lack of adequate staffing in other parts of the hospital that may be compromising patient safety. To reduce decision complexity, heuristic rules based on experience are often used to help think through the problem; for example, the patient's functional status or clinical gestalt. The intensive care doctors actively managed relationships with referring doctors; acted as the hospital generalist for acutely ill patients; and brought calm to crisis situations. However, they frequently failed to elicit values and preferences from patients or family members. They were rarely explicit in balancing burdens and benefits of intensive care for patients, so consistency and equity cannot be judged. The use of a framework for intensive care admission decisions that reminds doctors to seek patient or family views and encourages explicit balancing of burdens and benefits could improve decision-making. However, a supportive, adequately resourced context is also needed.", "doi": "10.1111/anae.15272", "pmid": "33141939", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-01T14:53:02.823Z", "modified": "2020-12-01T14:53:02.834Z"}, {"entity": "publication", "iuid": "fa9477a93058403489aaf9882b81d38a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa9477a93058403489aaf9882b81d38a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa9477a93058403489aaf9882b81d38a"}}, "title": "COVID-19 case-fatality rate and demographic and socioeconomic influencers: worldwide spatial regression analysis based on country-level data.", "authors": [{"family": "Cao", "given": "Yang", "initials": "Y", "orcid": "0000-0002-3552-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7594ca0fdf2d4f238ca04a788a405cdb.json"}}, {"family": "Hiyoshi", "given": "Ayako", "initials": "A"}, {"family": "Montgomery", "given": "Scott", "initials": "S", "orcid": "0000-0001-6328-5494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/601e7c2c4fa3497d91a6cef8f39b404d.json"}}], "type": "journal article", "published": "2020-11-03", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "10", "issue": "11", "pages": "e043560"}, "abstract": "To investigate the influence of demographic and socioeconomic factors on the COVID-19 case-fatality rate (CFR) globally.\n\nPublicly available register-based ecological study.\n\nTwo hundred and nine countries/territories in the world.\n\nAggregated data including 10 445 656 confirmed COVID-19 cases.\n\nCOVID-19 CFR and crude cause-specific death rate were calculated using country-level data from the Our World in Data website.\n\nThe average of country/territory-specific COVID-19 CFR is about 2%-3% worldwide and higher than previously reported at 0.7%-1.3%. A doubling in size of a population is associated with a 0.48% (95% CI 0.25% to 0.70%) increase in COVID-19 CFR, and a doubling in the proportion of female smokers is associated with a 0.55% (95% CI 0.09% to 1.02%) increase in COVID-19 CFR. The open testing policies are associated with a 2.23% (95% CI 0.21% to 4.25%) decrease in CFR. The strictness of anti-COVID-19 measures was not statistically significantly associated with CFR overall, but the higher Stringency Index was associated with higher CFR in higher-income countries with active testing policies (regression coefficient beta=0.14, 95% CI 0.01 to 0.27). Inverse associations were found between cardiovascular disease death rate and diabetes prevalence and CFR.\n\nThe association between population size and COVID-19 CFR may imply the healthcare strain and lower treatment efficiency in countries with large populations. The observed association between smoking in women and COVID-19 CFR might be due to the finding that the proportion of female smokers reflected broadly the income level of a country. When testing is warranted and healthcare resources are sufficient, strict quarantine and/or lockdown measures might result in excess deaths in underprivileged populations. Spatial dependence and temporal trends in the data should be taken into account in global joint strategy and/or policy making against the COVID-19 pandemic.", "doi": "10.1136/bmjopen-2020-043560", "pmid": "33148769", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7640588"}, {"db": "pii", "key": "bmjopen-2020-043560"}], "notes": [], "created": "2020-11-27T10:09:42.512Z", "modified": "2023-06-19T14:35:50.521Z"}, {"entity": "publication", "iuid": "bfd1e58754834c7199f78cfb8051d92a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bfd1e58754834c7199f78cfb8051d92a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bfd1e58754834c7199f78cfb8051d92a"}}, "title": "The COVID-19 pandemic: How predictive analysis, artificial intelligence and GIS can be integrated into a clinical command system to improve disaster response and preparedness.", "authors": [{"family": "Hertelendy", "given": "Attila J", "initials": "AJ"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}, {"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}], "type": "letter", "published": "2020-11-02", "journal": {"title": "Am J Emerg Med", "issn": "1532-8171", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.ajem.2020.10.049", "pmid": "33160803", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0735-6757(20)30945-1"}, {"db": "pmc", "key": "PMC7605801"}], "notes": [], "created": "2020-12-01T14:23:39.044Z", "modified": "2020-12-01T14:23:55.056Z"}, {"entity": "publication", "iuid": "9115762056744c4eb68986440242c8dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9115762056744c4eb68986440242c8dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9115762056744c4eb68986440242c8dd"}}, "title": "Epidemiological and Clinical Characteristics of COVID-19 in Children: A Systematic Review and Meta-Analysis.", "authors": [{"family": "Li", "given": "Bingbing", "initials": "B"}, {"family": "Zhang", "given": "Shan", "initials": "S"}, {"family": "Zhang", "given": "Ruili", "initials": "R"}, {"family": "Chen", "given": "Xi", "initials": "X"}, {"family": "Wang", "given": "Yong", "initials": "Y"}, {"family": "Zhu", "given": "Changlian", "initials": "C"}], "type": "systematic review", "published": "2020-11-02", "journal": {"title": "Front Pediatr", "issn": "2296-2360", "volume": "8", "issue": null, "pages": "591132", "issn-l": "2296-2360"}, "abstract": "Given the relatively low rate and limited publicly available data regarding children with SARS-CoV-2 infection, this knowledge gap should be addressed with urgency. This systematic review with meta-analysis aimed to evaluate the epidemiological spectrum and clinical characteristics of children infected with SARS-CoV-2. Relevant international and Chinese public databases were systematically searched to identify all case studies from January 1, 2020 to May 7, 2020. This study consisted of 96 studies involving 7004 cases. The mean age of pediatric cases was 6.48 years (95% CI 52.0-77.5), 90% had household contact, and 66% presented with mild to moderate clinical syndromes. The main symptoms were fever (47%, 95% CI 41-53%) and cough (42%, 95% CI 36-48%). About 23% of children were asymptomatic, 27% had comorbidity, and 29% had a co-infection. The pooled mean incubation period was 9.57 days (95% CI 7.70-11.44). The shedding of SARS-CoV-2 in the upper respiratory tract lasted 11.43 days, and 75% of patients had virus particles in their stool. A total of 34% of the children had neutropenia and 26% had lymphocytosis. Interferon-alpha (81%) was the most commonly used antiviral drug in the children. The discharge and death rates were 79 and 1%. In conclusion, the transmissibility of pediatric COVID-19 should be not ignored because of the relatively long incubation period, shedding duration, and mild clinical syndromes.", "doi": "10.3389/fped.2020.591132", "pmid": "33224909", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7667131"}], "notes": [], "created": "2020-11-26T12:32:45.094Z", "modified": "2020-11-26T12:32:45.103Z"}, {"entity": "publication", "iuid": "28640e6c60bf474198a68db6a0463bf6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/28640e6c60bf474198a68db6a0463bf6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/28640e6c60bf474198a68db6a0463bf6"}}, "title": "Expansion of SARS-CoV-2-Specific Antibody-Secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients.", "authors": [{"family": "Varnait\u0117", "given": "Renata", "initials": "R", "orcid": "0000-0001-9391-9291", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05a03781d1c84aad85895298c193c575.json"}}, {"family": "Garc\u00eda", "given": "Marina", "initials": "M", "orcid": "0000-0002-9130-3933", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5b109d7a54e4c05a48e0f21c4432be6.json"}}, {"family": "Glans", "given": "Hedvig", "initials": "H", "orcid": "0000-0002-7401-2245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ffccfdfb5ffa4d09ab2ae87655f30585.json"}}, {"family": "Maleki", "given": "Kimia T", "initials": "KT", "orcid": "0000-0001-5382-5477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c0313be527f49c0b41a37115a68408d.json"}}, {"family": "Sandberg", "given": "John Tyler", "initials": "JT", "orcid": "0000-0001-6747-6933", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dfe4b6f5f2f24420bd78d7ae9b71e2d4.json"}}, {"family": "Tynell", "given": "Janne", "initials": "J"}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f2dc27d02294a15a6f691be6aab641f.json"}}, {"family": "Lagerqvist", "given": "Nina", "initials": "N"}, {"family": "Asgeirsson", "given": "Hilmir", "initials": "H", "orcid": "0000-0003-3869-8021", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/870e3520475b41f8a4f39744b1ecb3ea.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG", "orcid": "0000-0003-0908-7387", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48a59f01e46c41038301a586178e8e2a.json"}}, {"family": "Ahl\u00e9n", "given": "Gustaf", "initials": "G"}, {"family": "Frelin", "given": "Lars", "initials": "L"}, {"family": "S\u00e4llberg", "given": "Matti", "initials": "M"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S", "orcid": "0000-0002-2446-4323", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/363ff940d9c64575a11bd45372927b2c.json"}}], "type": "journal article", "published": "2020-11-01", "journal": {"title": "J Immunol", "issn": "1550-6606", "issn-l": null, "volume": "205", "issue": "9", "pages": "2437-2446"}, "abstract": "Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in late 2019 and has since become a global pandemic. Pathogen-specific Abs are typically a major predictor of protective immunity, yet human B cell and Ab responses during COVID-19 are not fully understood. In this study, we analyzed Ab-secreting cell and Ab responses in 20 hospitalized COVID-19 patients. The patients exhibited typical symptoms of COVID-19 and presented with reduced lymphocyte numbers and increased T cell and B cell activation. Importantly, we detected an expansion of SARS-CoV-2 nucleocapsid protein-specific Ab-secreting cells in all 20 COVID-19 patients using a multicolor FluoroSpot Assay. Out of the 20 patients, 16 had developed SARS-CoV-2-neutralizing Abs by the time of inclusion in the study. SARS-CoV-2-specific IgA, IgG, and IgM Ab levels positively correlated with SARS-CoV-2-neutralizing Ab titers, suggesting that SARS-CoV-2-specific Ab levels may reflect the titers of neutralizing Abs in COVID-19 patients during the acute phase of infection. Last, we showed that IL-6 and C-reactive protein serum concentrations were higher in patients who were hospitalized for longer, supporting the recent observations that IL-6 and C-reactive protein could be used as markers for COVID-19 severity. Altogether, this study constitutes a detailed description of clinical and immunological parameters in 20 COVID-19 patients, with a focus on B cell and Ab responses, and describes tools to study immune responses to SARS-CoV-2 infection and vaccination.", "doi": "10.4049/jimmunol.2000717", "pmid": "32878912", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC7576114"}, {"db": "pii", "key": "jimmunol.2000717"}], "notes": [], "created": "2020-11-04T14:50:45.425Z", "modified": "2023-06-19T14:32:55.754Z"}, {"entity": "publication", "iuid": "5f5f0603074945a8bcfdfbded42b74f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f5f0603074945a8bcfdfbded42b74f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f5f0603074945a8bcfdfbded42b74f9"}}, "title": "Addressing Healthcare Gaps in Sweden during the COVID-19 Outbreak: On Community Outreach and Empowering Ethnic Minority Groups in a Digitalized Context.", "authors": [{"family": "Valeriani", "given": "Giuseppe", "initials": "G"}, {"family": "Sarajlic Vukovic", "given": "Iris", "initials": "I"}, {"family": "Lindegaard", "given": "Tomas", "initials": "T"}, {"family": "Felizia", "given": "Roberto", "initials": "R"}, {"family": "Mollica", "given": "Richard", "initials": "R"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}], "type": "journal article", "published": "2020-11-01", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "volume": "8", "issue": "4", "issn-l": null}, "abstract": "Since its early stages, the COVID-19 pandemic has interacted with existing divides by ethnicity and socioeconomic statuses, exacerbating further inequalities in high-income countries. The Swedish public health strategy, built on mutual trust between the government and the society and giving the responsibility to the individual, has been criticized for not applying a dedicated and more diverse strategy for most disadvantaged migrants in dealing with the pandemic. In order to mitigate the unequal burden on the marginalized members of society, increasing efforts have been addressed to digital health technologies. Despite the strong potential of providing collective public health benefits, especially in a highly digitalized context as Sweden, need for a stronger cooperation between the public health authorities and migrant community leaders, representatives of migrant associations, religious leaders and other influencers of disadvantaged groups has emerged. Suggestions are presented on more culturally congruent, patient-centered health care services aimed to empower people to participate in a more effective public health response to the COVID-19 crisis.", "doi": "10.3390/healthcare8040445", "pmid": "33139619", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "healthcare8040445"}], "notes": [], "created": "2020-12-01T14:56:27.725Z", "modified": "2020-12-01T14:56:27.749Z"}, {"entity": "publication", "iuid": "f34afa2a75de4523ae268c8024729da5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f34afa2a75de4523ae268c8024729da5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f34afa2a75de4523ae268c8024729da5"}}, "title": "Work at inpatient care units is associated with an increased risk of SARS-CoV-2 infection; a cross-sectional study of 8679 healthcare workers in Sweden.", "authors": [{"family": "Lidstr\u00f6m", "given": "Anna-Karin", "initials": "AK"}, {"family": "Sund", "given": "Fredrik", "initials": "F"}, {"family": "Albinsson", "given": "Bo", "initials": "B"}, {"family": "Lindb\u00e4ck", "given": "Johan", "initials": "J"}, {"family": "Westman", "given": "Gabriel", "initials": "G"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "volume": "125", "issue": "4", "pages": "305-310", "issn-l": "0300-9734"}, "abstract": "During the Covid-19 pandemic, the protection of healthcare workers has been in focus throughout the world, but the availability and quality of personal protective equipment has at times and in some settings been suboptimal.\n\nA total of 8679 healthcare workers and healthcare support staff in the county of Uppsala, north of Stockholm, were included in this cross-sectional study. All subjects were analysed for IgG anti-SARS-CoV-2, and predictors for positive serostatus were analysed in a logistic regression model including demographic parameters and self-reported employment characteristics.\n\nOverall, 577 (6.6%) were classified as seropositive, with no statistically significant differences between healthcare workers and support staff. Among healthcare workers, age (OR 0.987 per year, 95% CI 0.980-0.995), time to sampling (OR 1.019 per day, 95% CI 1.004-1.035), and employment at an outpatient care unit (OR 0.620, 95% CI 0.487-0.788) were statistically significantly associated with risk of infection. Covid-19 specific units were not at particular risk, compared to other units with comparable characteristics and staff demography.\n\nOur findings indicate that SARS-CoV-2 transmission is related to inpatient healthcare work, and illustrate the need for a high standard of basic hygiene routines in all inpatient care settings.", "doi": "10.1080/03009734.2020.1793039", "pmid": "32684119", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7594729"}], "notes": [], "created": "2020-11-18T17:32:37.256Z", "modified": "2021-02-26T08:45:48.851Z"}, {"entity": "publication", "iuid": "bdb516f3c98f4f7098054985e3b15024", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bdb516f3c98f4f7098054985e3b15024.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bdb516f3c98f4f7098054985e3b15024"}}, "title": "Will coronavirus disease (COVID-19) have an impact on antimicrobial resistance?", "authors": [{"family": "Monnet", "given": "Dominique L", "initials": "DL"}, {"family": "Harbarth", "given": "Stephan", "initials": "S"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "45", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.45.2001886", "pmid": "33183403", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7667630"}], "notes": [], "created": "2020-11-30T16:27:06.332Z", "modified": "2020-11-30T16:27:06.344Z"}, {"entity": "publication", "iuid": "884d64d5e3ab4443b5b428260d57c4e9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/884d64d5e3ab4443b5b428260d57c4e9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/884d64d5e3ab4443b5b428260d57c4e9"}}, "title": "Virological surveillance of influenza viruses in the WHO European Region in 2019/20 - impact of the COVID-19 pandemic.", "authors": [{"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "Pereyaslov", "given": "Dmitriy", "initials": "D"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "Prosenc", "given": "Katarina", "initials": "K"}, {"family": "Alm", "given": "Erik", "initials": "E"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Fielding", "given": "James", "initials": "J"}, {"family": "Sneiderman", "given": "Miriam", "initials": "M"}, {"family": "Martinuka", "given": "Oksana", "initials": "O"}, {"family": "Celentano", "given": "Lucia Pastore", "initials": "LP"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "WHO European Region influenza surveillance network", "given": "", "initials": ""}, {"family": "WHO European Region Influenza Surveillance Network author list", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "25", "issue": "46", "pages": null}, "abstract": "The COVID-19 pandemic negatively impacted the 2019/20 WHO European Region influenza surveillance. Compared with previous 4-year averages, antigenic and genetic characterisations decreased by 17% (3,140 vs 2,601) and 24% (4,474 vs 3,403). Of subtyped influenza A viruses, 56% (26,477/47,357) were A(H1)pdm09, 44% (20,880/47,357) A(H3). Of characterised B viruses, 98% (4,585/4,679) were B/Victoria. Considerable numbers of viruses antigenically differed from northern hemisphere vaccine components. In 2020/21, maintaining influenza virological surveillance, while supporting SARS-CoV-2 surveillance is crucial.", "doi": "10.2807/1560-7917.ES.2020.25.46.2001822", "pmid": "33213683", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7678039"}], "notes": [], "created": "2020-11-30T16:03:50.371Z", "modified": "2021-02-26T08:45:48.443Z"}, {"entity": "publication", "iuid": "cdca526a6b5d44c985559cb88dbd3572", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cdca526a6b5d44c985559cb88dbd3572.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cdca526a6b5d44c985559cb88dbd3572"}}, "title": "Using an integrated social cognition model to predict COVID-19 preventive behaviours.", "authors": [{"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Imani", "given": "Vida", "initials": "V"}, {"family": "Majd", "given": "Nilofar Rajabi", "initials": "NR"}, {"family": "Ghasemi", "given": "Zahra", "initials": "Z"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Hamilton", "given": "Kyra", "initials": "K"}, {"family": "Hagger", "given": "Martin S", "initials": "MS"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Br J Health Psychol", "issn": "2044-8287", "issn-l": null, "volume": "25", "issue": "4", "pages": "981-1005"}, "abstract": "Rates of novel coronavirus disease 2019 (COVID-19) infections have rapidly increased worldwide and reached pandemic proportions. A suite of preventive behaviours have been recommended to minimize risk of COVID-19 infection in the general population. The present study utilized an integrated social cognition model to explain COVID-19 preventive behaviours in a sample from the Iranian general population.\r\n\r\nThe study adopted a three-wave prospective correlational design.\r\n\r\nMembers of the general public (N = 1,718, M age = 33.34, SD = 15.77, male = 796, female = 922) agreed to participate in the study. Participants completed self-report measures of demographic characteristics, intention, attitude, subjective norm, perceived behavioural control, and action self-efficacy at an initial data collection occasion. One week later, participants completed self-report measures of maintenance self-efficacy, action planning and coping planning, and, a further week later, measures of COVID-19 preventive behaviours. Hypothesized relationships among social cognition constructs and COVID-19 preventive behaviours according to the proposed integrated model were estimated using structural equation modelling.\r\n\r\nThe proposed model fitted the data well according to multiple goodness-of-fit criteria. All proposed relationships among model constructs were statistically significant. The social cognition constructs with the largest effects on COVID-19 preventive behaviours were coping planning (\u03b2 = .575, p < .001) and action planning (\u03b2 = .267, p < .001).\r\n\r\nCurrent findings may inform the development of behavioural interventions in health care contexts by identifying intervention targets. In particular, findings suggest targeting change in coping planning and action planning may be most effective in promoting participation in COVID-19 preventive behaviours. Statement of contribution What is already known on this subject? Curbing COVID-19 infections globally is vital to reduce severe cases and deaths in at-risk groups. Preventive behaviours like handwashing and social distancing can stem contagion of the coronavirus. Identifying modifiable correlates of COVID-19 preventive behaviours is needed to inform intervention. What does this study add? An integrated model identified predictors of COVID-19 preventive behaviours in Iranian residents. Prominent predictors were intentions, planning, self-efficacy, and perceived behavioural control. Findings provide insight into potentially modifiable constructs that interventions can target. Research should examine if targeting these factors lead to changes in COVID-19 behaviours over time.", "doi": "10.1111/bjhp.12465", "pmid": "32780891", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7436576"}], "notes": [], "created": "2020-12-07T13:30:27.584Z", "modified": "2022-11-09T08:30:26.489Z"}, {"entity": "publication", "iuid": "040f98cfd40d407c994d51d6edbcc285", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/040f98cfd40d407c994d51d6edbcc285.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/040f98cfd40d407c994d51d6edbcc285"}}, "title": "The challenge of COVID-19 and hematopoietic cell transplantation; EBMT recommendations for management of hematopoietic cell transplant recipients, their donors, and patients undergoing CAR T-cell therapy.", "authors": [{"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Mikulska", "given": "Malgorzata", "initials": "M"}, {"family": "de la Camara", "given": "Rafael", "initials": "R"}, {"family": "Basak", "given": "Grzegorz W", "initials": "GW"}, {"family": "Chabannon", "given": "Christian", "initials": "C"}, {"family": "Corbacioglu", "given": "Selim", "initials": "S"}, {"family": "Duarte", "given": "Rafael", "initials": "R"}, {"family": "Dolstra", "given": "Harry", "initials": "H"}, {"family": "Lankester", "given": "Arjan C", "initials": "AC"}, {"family": "Mohty", "given": "Mohamad", "initials": "M"}, {"family": "Montoto", "given": "Silvia", "initials": "S"}, {"family": "Murray", "given": "John", "initials": "J"}, {"family": "Peffault de Latour", "given": "R\u00e9gis", "initials": "R"}, {"family": "Snowden", "given": "John A", "initials": "JA"}, {"family": "Yakoub-Agha", "given": "Ibrahim", "initials": "I"}, {"family": "Verhoeven", "given": "Bregje", "initials": "B"}, {"family": "Kr\u00f6ger", "given": "Nicolaus", "initials": "N"}, {"family": "Styczynski", "given": "Jan", "initials": "J"}, {"family": "European Society for Blood and Marrow Transplantation", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Bone Marrow Transplant", "issn": "1476-5365", "volume": "55", "issue": "11", "pages": "2071-2076", "issn-l": "0268-3369"}, "abstract": "The new coronavirus SARS-CoV-2 has rapidly spread over the world causing the disease by WHO called COVID-19. This pandemic poses unprecedented stress on the health care system including programs performing allogeneic and autologous hematopoietic cell transplantation (HCT) and cellular therapy such as with CAR T cells. Risk factors for severe disease include age and predisposing conditions such as cancer. The true impact on stem cell transplant and CAR T-cell recipients in unknown. The European Society for Blood and Marrow Transplantation (EBMT) has therefore developed recommendations for transplant programs and physicians caring for these patients. These guidelines were developed by experts from the Infectious Diseases Working Party and have been endorsed by EBMT's scientific council and board. This work intends to provide guidelines for transplant centers, management of transplant candidates and recipients, and donor issues until the COVID-19 pandemic has passed.", "doi": "10.1038/s41409-020-0919-0", "pmid": "32404975", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41409-020-0919-0"}, {"db": "pmc", "key": "PMC7220575"}], "notes": [], "created": "2020-11-26T12:17:04.466Z", "modified": "2020-12-10T08:45:08.633Z"}, {"entity": "publication", "iuid": "52852cdfbb244df3b213b74fd505f389", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/52852cdfbb244df3b213b74fd505f389.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/52852cdfbb244df3b213b74fd505f389"}}, "title": "The Potential of Low Molecular Weight Heparin to Mitigate Cytokine Storm in Severe COVID-19 Patients: A Retrospective Cohort Study.", "authors": [{"family": "Shi", "given": "Chen", "initials": "C"}, {"family": "Wang", "given": "Cong", "initials": "C"}, {"family": "Wang", "given": "Hanxiang", "initials": "H"}, {"family": "Yang", "given": "Chao", "initials": "C"}, {"family": "Cai", "given": "Fei", "initials": "F"}, {"family": "Zeng", "given": "Fang", "initials": "F"}, {"family": "Cheng", "given": "Fang", "initials": "F"}, {"family": "Liu", "given": "Yihui", "initials": "Y"}, {"family": "Zhou", "given": "Taotao", "initials": "T"}, {"family": "Deng", "given": "Bin", "initials": "B"}, {"family": "Vlodavsky", "given": "Israel", "initials": "I"}, {"family": "Li", "given": "Jin-Ping", "initials": "JP"}, {"family": "Zhang", "given": "Yu", "initials": "Y"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Clin Transl Sci", "issn": "1752-8062", "issn-l": "1752-8054", "volume": "13", "issue": "6", "pages": "1087-1095"}, "abstract": "On March 11, 2020, the World Health Organization declared its assessment of coronavirus disease 2019 (COVID-19) as a global pandemic. However, specific anti-severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) drugs are still under development, and patients are managed by multiple complementary treatments. We performed a retrospective analysis to compare and evaluate the effect of low molecular weight heparin (LMWH) treatment on disease progression. For this purpose, the clinical records and laboratory indicators were extracted from electronic medical records of 42 patients with COVID-19 (21 of whom were treated with LMWH, and 21 without LMWH) hospitalized (Union Hospital of Huazhong University of Science and Technology) from February 1 to March 15, 2020. Changes in the percentage of lymphocytes before and after LMWH treatment were significantly different from those in the control group (P = 0.011). Likewise, changes in the levels of D-dimer and fibrinogen degradation products in the LMWH group before and after treatment were significantly different from those in the control group (P = 0.035). Remarkably, IL-6 levels were significantly reduced after LMWH treatment (P = 0.006), indicating that, besides other beneficial properties, LMWH may exert an anti-inflammatory effect and attenuate in part the \"cytokine storm\" induced by the virus. Our results support the use of LMWH as a potential therapeutic drug for the treatment of COVID-19, paving the way for a subsequent well-controlled clinical study.", "doi": "10.1111/cts.12880", "pmid": "32881340", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7719364"}], "notes": [], "created": "2020-11-22T09:54:40.820Z", "modified": "2023-06-19T15:37:44.972Z"}, {"entity": "publication", "iuid": "30c03419298947d887addc0c0ff7cb9b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/30c03419298947d887addc0c0ff7cb9b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/30c03419298947d887addc0c0ff7cb9b"}}, "title": "Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future.", "authors": [{"family": "Mok", "given": "Vincent C T", "initials": "VCT"}, {"family": "Pendlebury", "given": "Sarah", "initials": "S"}, {"family": "Wong", "given": "Adrian", "initials": "A"}, {"family": "Alladi", "given": "Suvarna", "initials": "S"}, {"family": "Au", "given": "Lisa", "initials": "L"}, {"family": "Bath", "given": "Philip M", "initials": "PM"}, {"family": "Biessels", "given": "Geert Jan", "initials": "GJ"}, {"family": "Chen", "given": "Christopher", "initials": "C"}, {"family": "Cordonnier", "given": "Charlotte", "initials": "C"}, {"family": "Dichgans", "given": "Martin", "initials": "M"}, {"family": "Dominguez", "given": "Jacqueline", "initials": "J"}, {"family": "Gorelick", "given": "Philip B", "initials": "PB"}, {"family": "Kim", "given": "SangYun", "initials": "S"}, {"family": "Kwok", "given": "Timothy", "initials": "T"}, {"family": "Greenberg", "given": "Steven M", "initials": "SM"}, {"family": "Jia", "given": "Jianping", "initials": "J"}, {"family": "Kalaria", "given": "Rajesh", "initials": "R"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Naegandran", "given": "Kandiah", "initials": "K"}, {"family": "Lam", "given": "Linda C W", "initials": "LCW"}, {"family": "Lam", "given": "Bonnie Yin Ka", "initials": "BYK"}, {"family": "Lee", "given": "Allen T C", "initials": "ATC"}, {"family": "Markus", "given": "Hugh S", "initials": "HS"}, {"family": "O'Brien", "given": "John", "initials": "J"}, {"family": "Pai", "given": "Ming-Chyi", "initials": "MC"}, {"family": "Pantoni", "given": "Leonardo", "initials": "L"}, {"family": "Sachdev", "given": "Perminder", "initials": "P"}, {"family": "Skoog", "given": "Ingmar", "initials": "I"}, {"family": "Smith", "given": "Eric E", "initials": "EE"}, {"family": "Srikanth", "given": "Velandai", "initials": "V"}, {"family": "Suh", "given": "Guk-Hee", "initials": "GH"}, {"family": "Wardlaw", "given": "Joanna", "initials": "J"}, {"family": "Ko", "given": "Ho", "initials": "H"}, {"family": "Black", "given": "Sandra E", "initials": "SE"}, {"family": "Scheltens", "given": "Philip", "initials": "P"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Alzheimers Dement", "issn": "1552-5279", "volume": "16", "issue": "11", "pages": "1571-1581", "issn-l": "1552-5260"}, "abstract": "We have provided an overview on the profound impact of COVID-19 upon older people with Alzheimer's disease and other dementias and the challenges encountered in our management of dementia in different health-care settings, including hospital, out-patient, care homes, and the community during the COVID-19 pandemic. We have also proposed a conceptual framework and practical suggestions for health-care providers in tackling these challenges, which can also apply to the care of older people in general, with or without other neurological diseases, such as stroke or parkinsonism. We believe this review will provide strategic directions and set standards for health-care leaders in dementia, including governmental bodies around the world in coordinating emergency response plans for protecting and caring for older people with dementia amid the COIVD-19 outbreak, which is likely to continue at varying severity in different regions around the world in the medium term.", "doi": "10.1002/alz.12143", "pmid": "32789951", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7436526"}], "notes": [], "created": "2020-11-26T12:18:00.247Z", "modified": "2020-11-30T08:41:01.767Z"}, {"entity": "publication", "iuid": "9a77c42026f74ace999a6c8baae5ed4a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9a77c42026f74ace999a6c8baae5ed4a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9a77c42026f74ace999a6c8baae5ed4a"}}, "title": "Sports balls as potential SARS-CoV-2 transmission vectors.", "authors": [{"family": "Pelisser", "given": "Michel", "initials": "M"}, {"family": "Thompson", "given": "Joe", "initials": "J"}, {"family": "Majra", "given": "Dasha", "initials": "D"}, {"family": "Youhanna", "given": "Sonia", "initials": "S"}, {"family": "Stebbing", "given": "Justin", "initials": "J"}, {"family": "Davies", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Public Health Pract (Oxf)", "issn": "2666-5352", "volume": "1", "pages": "100029", "issn-l": null}, "abstract": "Objects passed from one player to another have not been assessed for their ability to transmit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We found that the surface of sport balls, notably a football, tennis ball, golf ball, and cricket ball could not harbour inactivated virus when it was swabbed onto the surface, even for 30 \u200bs. However, when high concentrations of 5000 \u200bdC/mL and 10,000 \u200bdC/mL are directly pipetted onto the balls, it could be detected after for short time periods. Sports objects can only harbour inactivated SARS-CoV-2 under specific, directly transferred conditions, but wiping with a dry tissue or moist 'baby wipe' or dropping and rolling the balls removes all detectable viral traces. This has helpful implications to sporting events.", "doi": "10.1016/j.puhip.2020.100029", "pmid": "34173569", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S2666-5352(20)30028-8"}, {"db": "pmc", "key": "PMC7350886"}], "notes": [], "created": "2021-06-28T18:09:36.233Z", "modified": "2021-08-23T14:39:57.598Z"}, {"entity": "publication", "iuid": "a107d4a9a1434c93ba1cbee8a5c6ca16", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a107d4a9a1434c93ba1cbee8a5c6ca16.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a107d4a9a1434c93ba1cbee8a5c6ca16"}}, "title": "Risks to healthcare workers following tracheal intubation of patients with COVID-19: a prospective international multicentre cohort study.", "authors": [{"family": "El-Boghdadly", "given": "K", "initials": "K"}, {"family": "Wong", "given": "D J N", "initials": "DJN"}, {"family": "Owen", "given": "R", "initials": "R"}, {"family": "Neuman", "given": "M D", "initials": "MD"}, {"family": "Pocock", "given": "S", "initials": "S"}, {"family": "Carlisle", "given": "J B", "initials": "JB"}, {"family": "Johnstone", "given": "C", "initials": "C"}, {"family": "Andruszkiewicz", "given": "P", "initials": "P"}, {"family": "Baker", "given": "P A", "initials": "PA"}, {"family": "Biccard", "given": "B M", "initials": "BM"}, {"family": "Bryson", "given": "G L", "initials": "GL"}, {"family": "Chan", "given": "M T V", "initials": "MTV"}, {"family": "Cheng", "given": "M H", "initials": "MH"}, {"family": "Chin", "given": "K J", "initials": "KJ"}, {"family": "Coburn", "given": "M", "initials": "M"}, {"family": "Jonsson Fagerlund", "given": "M", "initials": "M"}, {"family": "Myatra", "given": "S N", "initials": "SN"}, {"family": "Myles", "given": "P S", "initials": "PS"}, {"family": "O'Sullivan", "given": "E", "initials": "E"}, {"family": "Pasin", "given": "L", "initials": "L"}, {"family": "Shamim", "given": "F", "initials": "F"}, {"family": "van Klei", "given": "W A", "initials": "WA"}, {"family": "Ahmad", "given": "I", "initials": "I"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Anaesthesia", "issn": "1365-2044", "issn-l": "0003-2409", "volume": "75", "issue": "11", "pages": "1437-1447"}, "abstract": "Healthcare workers involved in aerosol-generating procedures, such as tracheal intubation, may be at elevated risk of acquiring COVID-19. However, the magnitude of this risk is unknown. We conducted a prospective international multicentre cohort study recruiting healthcare workers participating in tracheal intubation of patients with suspected or confirmed COVID-19. Information on tracheal intubation episodes, personal protective equipment use and subsequent provider health status was collected via self-reporting. The primary endpoint was the incidence of laboratory-confirmed COVID-19 diagnosis or new symptoms requiring self-isolation or hospitalisation after a tracheal intubation episode. Cox regression analysis examined associations between the primary endpoint and healthcare worker characteristics, procedure-related factors and personal protective equipment use. Between 23 March and 2 June 2020, 1718 healthcare workers from 503 hospitals in 17 countries reported 5148 tracheal intubation episodes. The overall incidence of the primary endpoint was 10.7% over a median (IQR [range]) follow-up of 32 (18-48 [0-116]) days. The cumulative incidence within 7, 14 and 21 days of the first tracheal intubation episode was 3.6%, 6.1% and 8.5%, respectively. The risk of the primary endpoint varied by country and was higher in women, but was not associated with other factors. Around 1 in 10 healthcare workers involved in tracheal intubation of patients with suspected or confirmed COVID-19 subsequently reported a COVID-19 outcome. This has human resource implications for institutional capacity to deliver essential healthcare services, and wider societal implications for COVID-19 transmission.", "doi": "10.1111/anae.15170", "pmid": "32516833", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7300828"}], "notes": [], "created": "2020-11-25T09:57:47.346Z", "modified": "2022-11-09T08:32:15.026Z"}, {"entity": "publication", "iuid": "9b49421a30994ffc84789e00e0c9f02d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b49421a30994ffc84789e00e0c9f02d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b49421a30994ffc84789e00e0c9f02d"}}, "title": "Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis: a multinational, retrospective study.", "authors": [{"family": "Lane", "given": "Jennifer C E", "initials": "JCE"}, {"family": "Weaver", "given": "James", "initials": "J"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "Abrahao", "given": "Maria Tereza F", "initials": "MTF"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Biedermann", "given": "Patricia", "initials": "P"}, {"family": "Banda", "given": "Juan M", "initials": "JM"}, {"family": "Burn", "given": "Edward", "initials": "E"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "Conover", "given": "Mitchell M", "initials": "MM"}, {"family": "Culhane", "given": "Aedin C", "initials": "AC"}, {"family": "Davydov", "given": "Alexander", "initials": "A"}, {"family": "DuVall", "given": "Scott L", "initials": "SL"}, {"family": "Dymshyts", "given": "Dmitry", "initials": "D"}, {"family": "Fernandez-Bertolin", "given": "Sergio", "initials": "S"}, {"family": "Fi\u0161ter", "given": "Kristina", "initials": "K"}, {"family": "Hardin", "given": "Jill", "initials": "J"}, {"family": "Hester", "given": "Laura", "initials": "L"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Kaas-Hansen", "given": "Benjamin Skov", "initials": "BS"}, {"family": "Kent", "given": "Seamus", "initials": "S"}, {"family": "Khosla", "given": "Sajan", "initials": "S"}, {"family": "Kolovos", "given": "Spyros", "initials": "S"}, {"family": "Lambert", "given": "Christophe G", "initials": "CG"}, {"family": "van der Lei", "given": "Johan", "initials": "J"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Makadia", "given": "Rupa", "initials": "R"}, {"family": "Margulis", "given": "Andrea V", "initials": "AV"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Mehta", "given": "Paras", "initials": "P"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Morgan-Stewart", "given": "Henry", "initials": "H"}, {"family": "Mosseveld", "given": "Mees", "initials": "M"}, {"family": "Newby", "given": "Danielle", "initials": "D"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Park", "given": "Rae Woong", "initials": "RW"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A"}, {"family": "Rao", "given": "Gowtham A", "initials": "GA"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Reps", "given": "Jenna", "initials": "J"}, {"family": "Rijnbeek", "given": "Peter", "initials": "P"}, {"family": "Sathappan", "given": "Selva Muthu Kumaran", "initials": "SMK"}, {"family": "Schuemie", "given": "Martijn", "initials": "M"}, {"family": "Seager", "given": "Sarah", "initials": "S"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Shoaibi", "given": "Azza", "initials": "A"}, {"family": "Spotnitz", "given": "Matthew", "initials": "M"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Torre", "given": "Carmen O", "initials": "CO"}, {"family": "Vizcaya", "given": "David", "initials": "D"}, {"family": "Wen", "given": "Haini", "initials": "H"}, {"family": "de Wilde", "given": "Marcel", "initials": "M"}, {"family": "Xie", "given": "Junqing", "initials": "J"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhuk", "given": "Oleg", "initials": "O"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "OHDSI-COVID-19 consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Lancet Rheumatol", "issn": "2665-9913", "volume": "2", "issue": "11", "pages": "e698-e711", "issn-l": null}, "abstract": "Hydroxychloroquine, a drug commonly used in the treatment of rheumatoid arthritis, has received much negative publicity for adverse events associated with its authorisation for emergency use to treat patients with COVID-19 pneumonia. We studied the safety of hydroxychloroquine, alone and in combination with azithromycin, to determine the risk associated with its use in routine care in patients with rheumatoid arthritis.\n\nIn this multinational, retrospective study, new user cohort studies in patients with rheumatoid arthritis aged 18 years or older and initiating hydroxychloroquine were compared with those initiating sulfasalazine and followed up over 30 days, with 16 severe adverse events studied. Self-controlled case series were done to further establish safety in wider populations, and included all users of hydroxychloroquine regardless of rheumatoid arthritis status or indication. Separately, severe adverse events associated with hydroxychloroquine plus azithromycin (compared with hydroxychloroquine plus amoxicillin) were studied. Data comprised 14 sources of claims data or electronic medical records from Germany, Japan, the Netherlands, Spain, the UK, and the USA. Propensity score stratification and calibration using negative control outcomes were used to address confounding. Cox models were fitted to estimate calibrated hazard ratios (HRs) according to drug use. Estimates were pooled where the I2 value was less than 0\u00b74.\n\nThe study included 956 374 users of hydroxychloroquine, 310 350 users of sulfasalazine, 323 122 users of hydroxychloroquine plus azithromycin, and 351 956 users of hydroxychloroquine plus amoxicillin. No excess risk of severe adverse events was identified when 30-day hydroxychloroquine and sulfasalazine use were compared. Self-controlled case series confirmed these findings. However, long-term use of hydroxychloroquine appeared to be associated with increased cardiovascular mortality (calibrated HR 1\u00b765 [95% CI 1\u00b712-2\u00b744]). Addition of azithromycin appeared to be associated with an increased risk of 30-day cardiovascular mortality (calibrated HR 2\u00b719 [95% CI 1\u00b722-3\u00b795]), chest pain or angina (1\u00b715 [1\u00b705-1\u00b726]), and heart failure (1\u00b722 [1\u00b702-1\u00b745]).\n\nHydroxychloroquine treatment appears to have no increased risk in the short term among patients with rheumatoid arthritis, but in the long term it appears to be associated with excess cardiovascular mortality. The addition of azithromycin increases the risk of heart failure and cardiovascular mortality even in the short term. We call for careful consideration of the benefit-risk trade-off when counselling those on hydroxychloroquine treatment.\n\nNational Institute for Health Research (NIHR) Oxford Biomedical Research Centre, NIHR Senior Research Fellowship programme, US National Institutes of Health, US Department of Veterans Affairs, Janssen Research and Development, IQVIA, Korea Health Industry Development Institute through the Ministry of Health and Welfare Republic of Korea, Versus Arthritis, UK Medical Research Council Doctoral Training Partnership, Foundation Alfonso Martin Escudero, Innovation Fund Denmark, Novo Nordisk Foundation, Singapore Ministry of Health's National Medical Research Council Open Fund Large Collaborative Grant, VINCI, Innovative Medicines Initiative 2 Joint Undertaking, EU's Horizon 2020 research and innovation programme, and European Federation of Pharmaceutical Industries and Associations.", "doi": "10.1016/S2665-9913(20)30276-9", "pmid": "32864627", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "http://evidence.ohdsi.org:3838/Covid19EstimationHydroxychloroquine/", "description": "Data aggregated by data source"}], "notes": [], "created": "2020-12-07T10:13:23.488Z", "modified": "2021-02-26T08:45:48.505Z"}, {"entity": "publication", "iuid": "ac2573f14bbc4fd98be9ce7ae7202b55", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac2573f14bbc4fd98be9ce7ae7202b55.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac2573f14bbc4fd98be9ce7ae7202b55"}}, "title": "Residential context and COVID-19 mortality among adults aged 70 years and older in Stockholm: a population-based, observational study using individual-level data.", "authors": [{"family": "Brand\u00e9n", "given": "Maria", "initials": "M"}, {"family": "Aradhya", "given": "Siddartha", "initials": "S"}, {"family": "Kolk", "given": "Martin", "initials": "M"}, {"family": "H\u00e4rk\u00f6nen", "given": "Juho", "initials": "J"}, {"family": "Drefahl", "given": "Sven", "initials": "S"}, {"family": "Malmberg", "given": "Bo", "initials": "B"}, {"family": "Rostila", "given": "Mikael", "initials": "M"}, {"family": "Cederstr\u00f6m", "given": "Agneta", "initials": "A"}, {"family": "Andersson", "given": "Gunnar", "initials": "G"}, {"family": "Mussino", "given": "Eleonora", "initials": "E"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Lancet Healthy Longev", "issn": "2666-7568", "volume": "1", "issue": "2", "pages": "e80-e88", "issn-l": null}, "abstract": "Housing characteristics and neighbourhood context are considered risk factors for COVID-19 mortality among older adults. The aim of this study was to investigate how individual-level housing and neighbourhood characteristics are associated with COVID-19 mortality in older adults.\n\nFor this population-based, observational study, we used data from the cause-of-death register held by the Swedish National Board of Health and Welfare to identify recorded COVID-19 mortality and mortality from other causes among individuals (aged \u226570 years) in Stockholm county, Sweden, between March 12 and May 8, 2020. This information was linked to population-register data from December, 2019, including socioeconomic, demographic, and residential characteristics. We ran Cox proportional hazards regressions for the risk of dying from COVID-19 and from all other causes. The independent variables were area (m 2) per individual in the household, the age structure of the household, type of housing, confirmed cases of COVID-19 in the borough, and neighbourhood population density. All models were adjusted for individual age, sex, country of birth, income, and education.\n\nOf 279 961 individuals identified to be aged 70 years or older on March 12, 2020, and residing in Stockholm in December, 2019, 274 712 met the eligibility criteria and were included in the study population. Between March 12 and May 8, 2020, 3386 deaths occurred, of which 1301 were reported as COVID-19 deaths. In fully adjusted models, household and neighbourhood characteristics were independently associated with COVID-19 mortality among older adults. Compared with living in a household with individuals aged 66 years or older, living with someone of working age (<66 years) was associated with increased COVID-19 mortality (hazard ratio 1\u00b76; 95% CI 1\u00b73-2\u00b70). Living in a care home was associated with an increased risk of COVID-19 mortality (4\u00b71; 3\u00b75-4\u00b79) compared with living in independent housing. Living in neighbourhoods with the highest population density (\u22655000 individuals per km 2) was associated with higher COVID-19 mortality (1\u00b77; 1\u00b71-2\u00b74) compared with living in the least densely populated neighbourhoods (0 to <150 individuals per km2).\n\nClose exposure to working-age household members and neighbours is associated with increased COVID-19 mortality among older adults. Similarly, living in a care home is associated with increased mortality, potentially through exposure to visitors and care workers, but also due to poor underlying health among care-home residents. These factors should be considered when developing strategies to protect this group.\n\nSwedish Research Council for Health, Working Life and Welfare (FORTE), Swedish Foundation for Humanities and Social Sciences.", "doi": "10.1016/S2666-7568(20)30016-7", "pmid": "33521770", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-7568(20)30016-7"}, {"db": "pmc", "key": "PMC7832817"}], "notes": [], "created": "2021-02-04T18:25:32.385Z", "modified": "2021-02-26T08:45:48.566Z"}, {"entity": "publication", "iuid": "8d3b6bf4b6704177a969022eb0453cca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d3b6bf4b6704177a969022eb0453cca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d3b6bf4b6704177a969022eb0453cca"}}, "title": "Pre-pandemic psychiatric disorders and risk of COVID-19: a UK Biobank cohort analysis.", "authors": [{"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Chen", "given": "Wenwen", "initials": "W"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Chen", "given": "Yilong", "initials": "Y"}, {"family": "Zeng", "given": "Yu", "initials": "Y"}, {"family": "Sun", "given": "Yajing", "initials": "Y"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "He", "given": "Junhui", "initials": "J"}, {"family": "Qu", "given": "Yuanyuan", "initials": "Y"}, {"family": "Lu", "given": "Donghao", "initials": "D"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Lancet Healthy Longev", "issn": "2666-7568", "volume": "1", "issue": "2", "pages": "e69-e79", "issn-l": null}, "abstract": "Psychiatric morbidities have been associated with a risk of severe infections through compromised immunity, health behaviours, or both. However, data are scarce on the association between multiple types of pre-pandemic psychiatric disorders and COVID-19. We aimed to assess the association between pre-pandemic psychiatric disorders and the subsequent risk of COVID-19 using UK Biobank.\n\nFor this cohort analysis, we included participants from UK Biobank who were registered in England and excluded individuals who died before Jan 31, 2020, (the start of the COVID-19 outbreak in the UK) or had withdrawn from UK Biobank. Participants diagnosed with a psychiatric disorder before Jan 31 were included in the group of individuals with pre-pandemic psychiatric disorders, whereas participants without a diagnosis before the outbreak were included in the group of individuals without pre-pandemic psychiatric disorders. We used the Public Health England dataset, UK Biobank hospital data, and death registers to collect data on COVID-19 cases. To examine the relationship between pre-pandemic psychiatric disorders and susceptibility to COVID-19, we used logistic regression models to estimate odds ratios (ORs), controlling for multiple confounders and somatic comorbidities. Key outcomes were all COVID-19, COVID-19 specifically diagnosed in inpatient care, and COVID-19-related deaths. ORs were also estimated separately for each psychiatric disorder and on the basis of the number of pre-pandemic psychiatric disorders. As a positive disease control, we repeated analyses for hospitalisation for other infections.\n\nWe included 421 014 UK Biobank participants in our study and assessed their COVID-19 status between Jan 31 and July 26, 2020. 50 809 participants were diagnosed with psychiatric disorders before the outbreak, while 370 205 participants had no psychiatric disorders. The mean age at outbreak was 67\u00b780 years (SD 8\u00b712). We observed an elevated risk of COVID-19 among individuals with pre-pandemic psychiatric disorders compared with that of individuals without such conditions. The fully adjusted ORs were 1\u00b744 (95% CI 1\u00b728-1\u00b762) for All COVID-19 cases, 1\u00b755 (1\u00b734-1\u00b778) for Inpatient COVID-19 cases, and 2\u00b703 (1\u00b759-2\u00b759) for COVID-19-related deaths. We observed excess risk, defined as risk that increased with the number of pre-pandemic psychiatric disorders, across all diagnostic categories of pre-pandemic psychiatric disorders. We also observed an association between psychiatric disorders and elevated risk of hospitalisation due to other infections (OR 1\u00b774, 95% CI 1\u00b758-1\u00b793).\n\nOur findings suggest that pre-existing psychiatric disorders are associated with an increased risk of COVID-19. These findings underscore the need for surveillance of and care for populations with pre-existing psychiatric disorders during the COVID-19 pandemic.\n\nNational Natural Science Foundation of China.", "doi": "10.1016/S2666-7568(20)30013-1", "pmid": "33521769", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2666-7568(20)30013-1"}, {"db": "pmc", "key": "PMC7832159"}], "notes": [], "created": "2021-02-04T18:27:04.421Z", "modified": "2021-02-26T08:47:00.051Z"}, {"entity": "publication", "iuid": "e2e4e3fe83c74ab3b2dee97372c04bb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2e4e3fe83c74ab3b2dee97372c04bb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2e4e3fe83c74ab3b2dee97372c04bb1"}}, "title": "Perspectives from CO+RE: How COVID-19 changed our food systems and food security paradigms.", "authors": [{"family": "Bakalis", "given": "Serafim", "initials": "S"}, {"family": "Valdramidis", "given": "Vasilis P", "initials": "VP"}, {"family": "Argyropoulos", "given": "Dimitrios", "initials": "D"}, {"family": "Ahrne", "given": "Lilia", "initials": "L"}, {"family": "Chen", "given": "Jianshe", "initials": "J"}, {"family": "Cullen", "given": "P J", "initials": "PJ"}, {"family": "Cummins", "given": "Enda", "initials": "E"}, {"family": "Datta", "given": "Ashim K", "initials": "AK"}, {"family": "Emmanouilidis", "given": "Christos", "initials": "C"}, {"family": "Foster", "given": "Tim", "initials": "T"}, {"family": "Fryer", "given": "Peter J", "initials": "PJ"}, {"family": "Gouseti", "given": "Ourania", "initials": "O"}, {"family": "Hospido", "given": "Almudena", "initials": "A"}, {"family": "Knoerzer", "given": "Kai", "initials": "K"}, {"family": "LeBail", "given": "Alain", "initials": "A"}, {"family": "Marangoni", "given": "Alejandro G", "initials": "AG"}, {"family": "Rao", "given": "Pingfan", "initials": "P"}, {"family": "Schl\u00fcter", "given": "Oliver K", "initials": "OK"}, {"family": "Taoukis", "given": "Petros", "initials": "P"}, {"family": "Xanthakis", "given": "Epameinondas", "initials": "E"}, {"family": "Van Impe", "given": "Jan F M", "initials": "JFM"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Curr Res Food Sci", "issn": "2665-9271", "issn-l": null, "volume": "3", "issue": null, "pages": "166-172"}, "abstract": "Perspective", "doi": "10.1016/j.crfs.2020.05.003", "pmid": "32908972", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2665-9271(20)30024-1"}, {"db": "pmc", "key": "PMC7265867"}], "notes": [], "created": "2020-12-03T15:52:32.403Z", "modified": "2020-12-03T15:53:22.094Z"}, {"entity": "publication", "iuid": "d3b317fa2c674197819672c405ab928b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3b317fa2c674197819672c405ab928b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3b317fa2c674197819672c405ab928b"}}, "title": "Periodontal disease and targeted prevention using aMMP-8 point-of-care oral fluid analytics in the COVID-19 era.", "authors": [{"family": "R\u00e4is\u00e4nen", "given": "Ismo T", "initials": "IT"}, {"family": "Umeizudike", "given": "Kehinde A", "initials": "KA"}, {"family": "P\u00e4rn\u00e4nen", "given": "Pirjo", "initials": "P"}, {"family": "Heikkil\u00e4", "given": "Pia", "initials": "P"}, {"family": "Tervahartiala", "given": "Taina", "initials": "T"}, {"family": "Nwhator", "given": "Solomon O", "initials": "SO"}, {"family": "Grigoriadis", "given": "Andreas", "initials": "A"}, {"family": "Sakellari", "given": "Dimitra", "initials": "D"}, {"family": "Sorsa", "given": "Timo", "initials": "T"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Med Hypotheses", "issn": "1532-2777", "volume": "144", "issue": null, "pages": "110276", "issn-l": null}, "abstract": "Periodontal disease is a chronic multifactorial infectious and inflammatory disease associated with several chronic systemic diseases, such as diabetes, cardiovascular diseases (CVD), chronic obstructive pulmonary disease, hypertension, Alzheimer's disease and so on. These same systemic diseases have been associated with severe COVID-19 infections. Several recent studies have suggested hypotheses for the potential association between periodontal disease and severe COVID-19. Periodontal disease is also one of the most prevalent diseases globally. All this supports the importance of good oral health, also in the COVID-19 era. Thus, new strategies and approaches to identify patients at risk of periodontal disease could be beneficial to enhance secondary prevention, especially if targeted to COVID-19 risk groups. Diagnostic biomarkers for periodontal disease have been researched extensively. Potential biomarkers in oral fluid with currently available rapid non-invasive point-of-care technology, such as aMMP-8, could help to extend screening and identification of patients at risk for periodontal disease also to situations and places where professional dental expertise and equipment are limited or unavailable. i.e., nursing and care homes, and rural and distant places. The oral fluid point-of-care technologies could also be useful in the hands of medical professionals (diabetes, CVD, etc.) to identify patients at risk for undiagnosed periodontal disease and to refer them to a dentist for examination and evaluation. Finally, if there is a causality between periodontal disease and severe COVID-19 infections, these point-of-care oral fluid biomarker technologies could possibly also help in the assessment of the risk of deterioration and complications.", "doi": "10.1016/j.mehy.2020.110276", "pmid": "33254580", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0306-9877(20)32157-5"}], "notes": [], "created": "2020-12-03T08:21:29.104Z", "modified": "2021-02-26T08:45:48.749Z"}, {"entity": "publication", "iuid": "2c69f0d6d0894d9ba02912d78ac4d7c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c69f0d6d0894d9ba02912d78ac4d7c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c69f0d6d0894d9ba02912d78ac4d7c0"}}, "title": "Partisan differences in physical distancing are linked to health outcomes during the COVID-19 pandemic.", "authors": [{"family": "Gollwitzer", "given": "Anton", "initials": "A"}, {"family": "Martel", "given": "Cameron", "initials": "C"}, {"family": "Brady", "given": "William J", "initials": "WJ"}, {"family": "P\u00e4rnamets", "given": "Philip", "initials": "P"}, {"family": "Freedman", "given": "Isaac G", "initials": "IG"}, {"family": "Knowles", "given": "Eric D", "initials": "ED"}, {"family": "Van Bavel", "given": "Jay J", "initials": "JJ"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Nat Hum Behav", "issn": "2397-3374", "issn-l": "2397-3374", "volume": "4", "issue": "11", "pages": "1186-1197"}, "abstract": "Numerous polls suggest that COVID-19 is a profoundly partisan issue in the United States. Using the geotracking data of 15 million smartphones per day, we found that US counties that voted for Donald Trump (Republican) over Hillary Clinton (Democrat) in the 2016 presidential election exhibited 14% less physical distancing between March and May 2020. Partisanship was more strongly associated with physical distancing than numerous other factors, including counties' COVID-19 cases, population density, median income, and racial and age demographics. Contrary to our predictions, the observed partisan gap strengthened over time and remained when stay-at-home orders were active. Additionally, county-level consumption of conservative media (Fox News) was related to reduced physical distancing. Finally, the observed partisan differences in distancing were associated with subsequently higher COVID-19 infection and fatality growth rates in pro-Trump counties. Taken together, these data suggest that US citizens' responses to COVID-19 are subject to a deep-and consequential-partisan divide.", "doi": "10.1038/s41562-020-00977-7", "pmid": "33139897", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41562-020-00977-7"}], "notes": [], "created": "2020-11-27T10:14:47.352Z", "modified": "2022-11-09T08:32:46.853Z"}, {"entity": "publication", "iuid": "99a5591d953744048ca94c23f5b35e2a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/99a5591d953744048ca94c23f5b35e2a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/99a5591d953744048ca94c23f5b35e2a"}}, "title": "Outcomes following SARS-CoV-2 infection in liver transplant recipients: an international registry study.", "authors": [{"family": "Webb", "given": "Gwilym J", "initials": "GJ"}, {"family": "Marjot", "given": "Thomas", "initials": "T"}, {"family": "Cook", "given": "Jonathan A", "initials": "JA"}, {"family": "Aloman", "given": "Costica", "initials": "C"}, {"family": "Armstrong", "given": "Matthew J", "initials": "MJ"}, {"family": "Brenner", "given": "Erica J", "initials": "EJ"}, {"family": "Catana", "given": "Maria-Andreea", "initials": "MA"}, {"family": "Cargill", "given": "Tamsin", "initials": "T"}, {"family": "Dhanasekaran", "given": "Renumathy", "initials": "R"}, {"family": "Garc\u00eda-Ju\u00e1rez", "given": "Ignacio", "initials": "I"}, {"family": "Hagstr\u00f6m", "given": "Hannes", "initials": "H"}, {"family": "Kennedy", "given": "James M", "initials": "JM"}, {"family": "Marshall", "given": "Aileen", "initials": "A"}, {"family": "Masson", "given": "Steven", "initials": "S"}, {"family": "Mercer", "given": "Carolyn J", "initials": "CJ"}, {"family": "Perumalswami", "given": "Ponni V", "initials": "PV"}, {"family": "Ruiz", "given": "Isaac", "initials": "I"}, {"family": "Thaker", "given": "Sarang", "initials": "S"}, {"family": "Ufere", "given": "Nneka N", "initials": "NN"}, {"family": "Barnes", "given": "Eleanor", "initials": "E"}, {"family": "Barritt", "given": "Alfred S", "initials": "AS"}, {"family": "Moon", "given": "Andrew M", "initials": "AM"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Lancet Gastroenterol Hepatol", "issn": "2468-1253", "volume": "5", "issue": "11", "pages": "1008-1016", "issn-l": null}, "abstract": "Despite concerns that patients with liver transplants might be at increased risk of adverse outcomes from COVID-19 because of coexisting comorbidities and use of immunosuppressants, the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on this patient group remains unclear. We aimed to assess the clinical outcomes in these patients.\n\nIn this multicentre cohort study, we collected data on patients with laboratory-confirmed SARS-CoV-2 infection, who were older than 18 years, who had previously received a liver transplant, and for whom data had been submitted by clinicians to one of two international registries (COVID-Hep and SECURE-Cirrhosis) at the end of the patient's disease course. Patients without a known hospitalisation status or mortality outcome were excluded. For comparison, data from a contemporaneous cohort of consecutive patients with SARS-CoV-2 infection who had not received a liver transplant were collected from the electronic patient records of the Oxford University Hospitals National Health Service Foundation Trust. We compared the cohorts with regard to several outcomes (including death, hospitalisation, intensive care unit [ICU] admission, requirement for intensive care, and need for invasive ventilation). A propensity score-matched analysis was done to test for an association between liver transplant and death.\n\nBetween March 25 and June 26, 2020, data were collected for 151 adult liver transplant recipients from 18 countries (median age 60 years [IQR 47-66], 102 [68%] men, 49 [32%] women) and 627 patients who had not undergone liver transplantation (median age 73 years [44-84], 329 [52%] men, 298 [48%] women). The groups did not differ with regard to the proportion of patients hospitalised (124 [82%] patients in the liver transplant cohort vs 474 [76%] in the comparison cohort, p=0\u00b7106), or who required intensive care (47 [31%] vs 185 [30%], p=0\u00b7837). However, ICU admission (43 [28%] vs 52 [8%], p<0\u00b70001) and invasive ventilation (30 [20%] vs 32 [5%], p<0\u00b70001) were more frequent in the liver transplant cohort. 28 (19%) patients in the liver transplant cohort died, compared with 167 (27%) in the comparison cohort (p=0\u00b7046). In the propensity score-matched analysis (adjusting for age, sex, creatinine concentration, obesity, hypertension, diabetes, and ethnicity), liver transplantation did not significantly increase the risk of death in patients with SARS-CoV-2 infection (absolute risk difference 1\u00b74% [95% CI -7\u00b77 to 10\u00b74]). Multivariable logistic regression analysis showed that age (odds ratio 1\u00b706 [95% CI 1\u00b701 to 1\u00b711] per 1 year increase), serum creatinine concentration (1\u00b757 [1\u00b705 to 2\u00b736] per 1 mg/dL increase), and non-liver cancer (18\u00b730 [1\u00b796 to 170\u00b775]) were associated with death among liver transplant recipients.\n\nLiver transplantation was not independently associated with death, whereas increased age and presence of comorbidities were. Factors other than transplantation should be preferentially considered in relation to physical distancing and provision of medical care for patients with liver transplants during the COVID-19 pandemic.\n\nEuropean Association for the Study of the Liver, US National Institutes of Health, UK National Institute for Health Research.", "doi": "10.1016/S2468-1253(20)30271-5", "pmid": "32866433", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2468-1253(20)30271-5"}, {"db": "pmc", "key": "PMC7455160"}], "notes": [], "created": "2020-12-07T07:52:04.415Z", "modified": "2021-02-26T08:45:48.494Z"}, {"entity": "publication", "iuid": "da1a6cf9002a49bfa808f8b5c9f6ed12", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/da1a6cf9002a49bfa808f8b5c9f6ed12.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/da1a6cf9002a49bfa808f8b5c9f6ed12"}}, "title": "On-demand mobile health infrastructures to allow comprehensive remote atrial fibrillation and risk factor management through teleconsultation.", "authors": [{"family": "Hermans", "given": "Astrid N L", "initials": "ANL"}, {"family": "van der Velden", "given": "Rachel M J", "initials": "RMJ"}, {"family": "Gawalko", "given": "Monika", "initials": "M"}, {"family": "Verhaert", "given": "Dominique V M", "initials": "DVM"}, {"family": "Desteghe", "given": "Lien", "initials": "L"}, {"family": "Duncker", "given": "David", "initials": "D"}, {"family": "Manninger", "given": "Martin", "initials": "M"}, {"family": "Heidbuchel", "given": "Hein", "initials": "H"}, {"family": "Pisters", "given": "Ron", "initials": "R"}, {"family": "Hemels", "given": "Martin", "initials": "M"}, {"family": "Pison", "given": "Laurent", "initials": "L"}, {"family": "Sohaib", "given": "Afzal", "initials": "A"}, {"family": "Sultan", "given": "Arian", "initials": "A"}, {"family": "Steven", "given": "Daniel", "initials": "D"}, {"family": "Wijtvliet", "given": "Petra", "initials": "P"}, {"family": "Tieleman", "given": "Robert", "initials": "R"}, {"family": "Gupta", "given": "Dhiraj", "initials": "D"}, {"family": "Dobrev", "given": "Dobromir", "initials": "D"}, {"family": "Svennberg", "given": "Emma", "initials": "E"}, {"family": "Crijns", "given": "Harry J G M", "initials": "HJGM"}, {"family": "Pluymaekers", "given": "Nikki A H A", "initials": "NAHA"}, {"family": "Hendriks", "given": "Jeroen M", "initials": "JM"}, {"family": "Linz", "given": "Dominik", "initials": "D"}, {"family": "TeleCheck-AF investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Clin Cardiol", "issn": "1932-8737", "volume": "43", "issue": "11", "pages": "1232-1239", "issn-l": "0160-9289"}, "abstract": "Although novel teleconsultation solutions can deliver remote situations that are relatively similar to face-to-face interaction, remote assessment of heart rate and rhythm as well as risk factors remains challenging in patients with atrial fibrillation (AF).\n\nMobile health (mHealth) solutions can support remote AF management.\n\nHerein, we discuss available mHealth tools and strategies on how to incorporate the remote assessment of heart rate, rhythm and risk factors to allow comprehensive AF management through teleconsultation.\n\nParticularly, in the light of the coronavirus disease 2019 (COVID-19) pandemic, there is decreased capacity to see patients in the outpatient clinic and mHealth has become an important component of many AF outpatient clinics. Several validated mHealth solutions are available for remote heart rate and rhythm monitoring as well as for risk factor assessment. mHealth technologies can be used for (semi-)continuous longitudinal monitoring or for short-term on-demand monitoring, dependent on the respective requirements and clinical scenarios. As a possible solution to improve remote AF care through teleconsultation, we introduce the on-demand TeleCheck-AF mHealth approach that allows remote app-based assessment of heart rate and rhythm around teleconsultations, which has been developed and implemented during the COVID-19 pandemic in Europe.\n\nLarge scale international mHealth projects, such as TeleCheck-AF, will provide insight into the additional value and potential limitations of mHealth strategies to remotely manage AF patients. Such mHealth infrastructures may be well suited within an integrated AF-clinic, which may require redesign of practice and reform of health care systems.", "doi": "10.1002/clc.23469", "pmid": "33030259", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7661648"}], "notes": [], "created": "2020-11-26T12:36:00.991Z", "modified": "2020-11-27T12:38:58.997Z"}, {"entity": "publication", "iuid": "f55490e3a83d4d75b26c47c0548597a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f55490e3a83d4d75b26c47c0548597a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f55490e3a83d4d75b26c47c0548597a9"}}, "title": "International registry of otolaryngologist-head and neck surgeons with COVID-19.", "authors": [{"family": "Sowerby", "given": "Leigh J", "initials": "LJ"}, {"family": "Stephenson", "given": "Kate", "initials": "K"}, {"family": "Dickie", "given": "Alexander", "initials": "A"}, {"family": "Lella", "given": "Federico A Di", "initials": "FAD"}, {"family": "Jefferson", "given": "Niall", "initials": "N"}, {"family": "North", "given": "Hannah", "initials": "H"}, {"family": "De Siati", "given": "R Daniele", "initials": "RD"}, {"family": "Maunsell", "given": "Rebecca", "initials": "R"}, {"family": "Herzog", "given": "Michael", "initials": "M"}, {"family": "Nandhan", "given": "Raghu", "initials": "R"}, {"family": "Trozzi", "given": "Marilena", "initials": "M"}, {"family": "Dehgani-Mobaraki", "given": "Puya", "initials": "P"}, {"family": "Melkane", "given": "Antoine", "initials": "A"}, {"family": "Callejas", "given": "Claudio", "initials": "C"}, {"family": "Miljeteig", "given": "Harald", "initials": "H"}, {"family": "Smit", "given": "Diane", "initials": "D"}, {"family": "Reynoso", "given": "Daniel Dibildox", "initials": "DD"}, {"family": "Moura", "given": "Joao Eloi", "initials": "JE"}, {"family": "Hermansson", "given": "Ann", "initials": "A"}, {"family": "Peer", "given": "Shazia", "initials": "S"}, {"family": "Burnell", "given": "Lisa", "initials": "L"}, {"family": "Fakhry", "given": "Nicolas", "initials": "N"}, {"family": "Chiesa-Estomba", "given": "Carlos", "initials": "C"}, {"family": "\u00d6nerci \u00c7elebi", "given": "\u00d6zlem", "initials": "\u00d6"}, {"family": "Karpischenko", "given": "Sergei", "initials": "S"}, {"family": "Sobol", "given": "Steven", "initials": "S"}, {"family": "Sargi", "given": "Zoukaa", "initials": "Z"}, {"family": "Patel", "given": "Zara M", "initials": "ZM"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Int Forum Allergy Rhinol", "issn": "2042-6984", "volume": "10", "issue": "11", "pages": "1201-1208", "issn-l": "2042-6976"}, "abstract": "It has become clear that healthcare workers are at high risk, and otolaryngology has been theorized to be among the highest risk specialties for coronavirus disease 2019 (COVID-19). The purpose of this study was to detail the international impact of COVID-19 among otolaryngologists, and to identify instructional cases.\n\nCountry representatives of the Young Otolaryngologists-International Federation of Otolaryngologic Societies (YO-IFOS) surveyed otolaryngologists through various channels. Nationwide surveys were distributed in 19 countries. The gray literature and social media channels were searched to identify reported deaths of otolaryngologists from COVID-19.\n\nA total of 361 otolaryngologists were identified to have had COVID-19, and data for 325 surgeons was available for analysis. The age range was 25 to 84 years, with one-half under the age of 44 years. There were 24 deaths in the study period, with 83% over age 55 years. Source of infection was likely clinical activity in 175 (54%) cases. Prolonged exposure to a colleague was the source for 37 (11%) surgeons. Six instructional cases were identified where infections occurred during the performance of aerosol-generating operations (tracheostomy, mastoidectomy, epistaxis control, dacryocystorhinostomy, and translabyrinthine resection). In 3 of these cases, multiple operating room attendees were infected, and in 2, the surgeon succumbed to complications of COVID-19.\n\nThe etiology of reported cases within the otolaryngology community appear to stem equally from clinical activity and community spread. Multiple procedures performed by otolaryngologists are aerosol-generating procedures (AGPs) and great care should be taken to protect the surgical team before, during, and after these operations.", "doi": "10.1002/alr.22677", "pmid": "32735062", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-07T16:05:56.221Z", "modified": "2021-02-26T08:45:48.857Z"}, {"entity": "publication", "iuid": "afe9178d3e2f40838664abeb888a2a94", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/afe9178d3e2f40838664abeb888a2a94.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/afe9178d3e2f40838664abeb888a2a94"}}, "title": "Intensive care unit admissions for pregnant and nonpregnant women with coronavirus disease 2019.", "authors": [{"family": "Westgren", "given": "Magnus", "initials": "M"}, {"family": "Acharya", "given": "Ganesh", "initials": "G"}], "type": "letter", "published": "2020-11-00", "journal": {"title": "Am J Obstet Gynecol", "issn": "1097-6868", "volume": "223", "issue": "5", "pages": "779-780", "issn-l": null}, "abstract": null, "doi": "10.1016/j.ajog.2020.07.046", "pmid": "32721395", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0002-9378(20)30777-8"}, {"db": "pmc", "key": "PMC7382351"}], "notes": [], "created": "2020-12-07T16:10:21.169Z", "modified": "2020-12-07T16:10:21.192Z"}, {"entity": "publication", "iuid": "e84db98dcc2d4608b3f67826eaa81562", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e84db98dcc2d4608b3f67826eaa81562.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e84db98dcc2d4608b3f67826eaa81562"}}, "title": "In silico drug discovery of major metabolites from spices as SARS-CoV-2 main protease inhibitors.", "authors": [{"family": "Ibrahim", "given": "Mahmoud A A", "initials": "MAA"}, {"family": "Abdelrahman", "given": "Alaa H M", "initials": "AHM"}, {"family": "Hussien", "given": "Taha A", "initials": "TA"}, {"family": "Badr", "given": "Esraa A A", "initials": "EAA"}, {"family": "Mohamed", "given": "Tarik A", "initials": "TA"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}, {"family": "Pare", "given": "Paul W", "initials": "PW"}, {"family": "Efferth", "given": "Thomas", "initials": "T"}, {"family": "Hegazy", "given": "Mohamed-Elamir F", "initials": "MF"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Comput Biol Med", "issn": "1879-0534", "issn-l": null, "volume": "126", "issue": null, "pages": "104046"}, "abstract": "Coronavirus Disease 2019 (COVID-19) is an infectious illness caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), originally identified in Wuhan, China (December 2019) and has since expanded into a pandemic. Here, we investigate metabolites present in several common spices as possible inhibitors of COVID-19. Specifically, 32 compounds isolated from 14 cooking seasonings were examined as inhibitors for SARS-CoV-2 main protease (M pro), which is required for viral multiplication. Using a drug discovery approach to identify possible antiviral leads, in silico molecular docking studies were performed. Docking calculations revealed a high potency of salvianolic acid A and curcumin as Mpro inhibitors with binding energies of -9.7 and -9.2 kcal/mol, respectively. Binding mode analysis demonstrated the ability of salvianolic acid A and curcumin to form nine and six hydrogen bonds, respectively with amino acids proximal to Mpro's active site. Stabilities and binding affinities of the two identified natural spices were calculated over 40 ns molecular dynamics simulations and compared to an antiviral protease inhibitor (lopinavir). Molecular mechanics-generalized Born surface area energy calculations revealed greater salvianolic acid A affinity for the enzyme over curcumin and lopinavir with energies of -44.8, -34.2 and -34.8 kcal/mol, respectively. Using a STRING database, protein-protein interactions were identified for salvianolic acid A included the biochemical signaling genes ACE, MAPK14 and ESR1; and for curcumin, EGFR and TNF. This study establishes salvianolic acid A as an in silico natural product inhibitor against the SARS-CoV-2 main protease and provides a promising inhibitor lead for in vitro enzyme testing.", "doi": "10.1016/j.compbiomed.2020.104046", "pmid": "33065388", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S0010-4825(20)30377-2"}, {"db": "pmc", "key": "PMC7543985"}], "notes": [], "created": "2020-12-01T17:08:08.474Z", "modified": "2021-02-26T08:45:25.924Z"}, {"entity": "publication", "iuid": "fc7c4566185d4cc0bffd118dcbad5cbf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc7c4566185d4cc0bffd118dcbad5cbf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc7c4566185d4cc0bffd118dcbad5cbf"}}, "title": "Impacts of COVID-19 on public transport ridership in Sweden: Analysis of ticket validations, sales and passenger counts.", "authors": [{"family": "Jenelius", "given": "Erik", "initials": "E"}, {"family": "Cebecauer", "given": "Matej", "initials": "M"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Transp Res Interdiscip Perspect", "issn": "2590-1982", "issn-l": null, "volume": "8", "issue": null, "pages": "100242"}, "abstract": "The paper analyses the impacts of COVID-19 on daily public transport ridership in the three most populated regions of Sweden (Stockholm, V\u00e4stra G\u00f6taland and Sk\u00e5ne) during spring 2020. The analysis breaks down the overall ridership with respect to ticket types, youths and seniors, and transport modes based on ticket validations, sales and passenger counts data. By utilizing disaggregate ticket validation data with consistent card ids we further investigate to what extent fewer people travelled, or each person travelled less, during the pandemic. The decrease in public transport ridership (40%-60% across regions) was severe compared with other transport modes. Ridership was not restricted by service levels as supply generally remained unchanged throughout the period. The ridership reduction stems primarily from a lower number of active public transport travellers. Travellers switched from monthly period tickets to single tickets and travel funds, while the use and the sales of short period tickets, used predominantly by tourists, dropped to almost zero. One-year period tickets and school tickets increased from mid-April, which could indicate that the travellers using these tickets are particularly captive to the public transport system. Collaborative effort is required to put the results in the international context.", "doi": "10.1016/j.trip.2020.100242", "pmid": "34173478", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S2590-1982(20)30153-6"}, {"db": "pmc", "key": "PMC7575262"}], "notes": [], "created": "2021-06-28T18:10:46.293Z", "modified": "2022-11-09T08:33:38.780Z"}, {"entity": "publication", "iuid": "9bbc433be67043b186493edb7eae38df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9bbc433be67043b186493edb7eae38df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9bbc433be67043b186493edb7eae38df"}}, "title": "Human recombinant soluble ACE2 in severe COVID-19.", "authors": [{"family": "Zoufaly", "given": "Alexander", "initials": "A"}, {"family": "Poglitsch", "given": "Marko", "initials": "M"}, {"family": "Aberle", "given": "Judith H", "initials": "JH"}, {"family": "Hoepler", "given": "Wolfgang", "initials": "W"}, {"family": "Seitz", "given": "Tamara", "initials": "T"}, {"family": "Traugott", "given": "Marianna", "initials": "M"}, {"family": "Grieb", "given": "Alexander", "initials": "A"}, {"family": "Pawelka", "given": "Erich", "initials": "E"}, {"family": "Laferl", "given": "Hermann", "initials": "H"}, {"family": "Wenisch", "given": "Christoph", "initials": "C"}, {"family": "Neuhold", "given": "Stephanie", "initials": "S"}, {"family": "Haider", "given": "Doris", "initials": "D"}, {"family": "Stiasny", "given": "Karin", "initials": "K"}, {"family": "Bergthaler", "given": "Andreas", "initials": "A"}, {"family": "Puchhammer-Stoeckl", "given": "Elisabeth", "initials": "E"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Montserrat", "given": "Nuria", "initials": "N"}, {"family": "Zhang", "given": "Haibo", "initials": "H"}, {"family": "Slutsky", "given": "Arthur S", "initials": "AS"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}], "type": "case reports", "published": "2020-11-00", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "volume": "8", "issue": "11", "pages": "1154-1158", "issn-l": "2213-2600"}, "abstract": "Case report", "doi": "10.1016/S2213-2600(20)30418-5", "pmid": "33131609", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(20)30418-5"}, {"db": "pmc", "key": "PMC7515587"}], "notes": [], "created": "2020-11-27T10:17:02.154Z", "modified": "2021-01-22T12:06:19.752Z"}, {"entity": "publication", "iuid": "7557f87aee3a4ff6a775af1a300c884c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7557f87aee3a4ff6a775af1a300c884c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7557f87aee3a4ff6a775af1a300c884c"}}, "title": "Fact vs Fallacy: The Anti-Vaccine Discussion Reloaded.", "authors": [{"family": "Stolle", "given": "Lucas B", "initials": "LB"}, {"family": "Nalamasu", "given": "Rohit", "initials": "R"}, {"family": "Pergolizzi", "given": "Joseph V", "initials": "JV"}, {"family": "Varrassi", "given": "Giustino", "initials": "G"}, {"family": "Magnusson", "given": "Peter", "initials": "P"}, {"family": "LeQuang", "given": "JoAnn", "initials": "J"}, {"family": "Breve", "given": "Frank", "initials": "F"}, {"family": "NEMA Research Group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Adv Ther", "issn": "1865-8652", "volume": "37", "issue": "11", "pages": "4481-4490", "issn-l": "0741-238X"}, "abstract": "In the light of the COVID-19 pandemic, anti-vaccine sentiments have been on the rise, with a recent seminal study on the development of anti-vaccine views in social media even making its way into Nature Communications. Yet, with the current scientific consensus being in overwhelming agreement over the safety and efficacy of vaccines, many scientists lose their grasp on the fears, concerns, and arguments that the opposition may hold. This paper discusses and evaluates vaccine-hesitant individuals on a socioeconomic, historical, and philosophical landscape. It also provides an analysis of common argumentative patterns and the psychological impact that these arguments may have on undecided individuals. The discussion also explores why anti-vaccine sentiments are on the rise, and how members of the scientific and medical community require a more structured approach to communicating key arguments. This is particularly important if vaccination rates and herd immunity are to be sustained. No longer is it sufficient to win arguments based on a factual and scientific basis, but rather scientists and medical practitioners have to focus on conveying confidence and reassurance on both an informative and emotional level to those with doubts and fears.", "doi": "10.1007/s12325-020-01502-y", "pmid": "32965654", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s12325-020-01502-y"}, {"db": "pmc", "key": "PMC7509825"}], "notes": [], "created": "2020-11-22T09:53:01.112Z", "modified": "2020-11-22T09:53:01.131Z"}, {"entity": "publication", "iuid": "72403b0041cd47e1bd619539665ce532", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/72403b0041cd47e1bd619539665ce532.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/72403b0041cd47e1bd619539665ce532"}}, "title": "Excess deaths from COVID-19 correlate with age and socio-economic status. A database study in the Stockholm region.", "authors": [{"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "F\u00fcrst", "given": "Per", "initials": "P"}, {"family": "Schultz", "given": "Torbj\u00f6rn", "initials": "T"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "issn-l": "0300-9734", "volume": "125", "issue": "4", "pages": "297-304"}, "abstract": "The COVID-19 pandemic has affected the entire health care system, internationally as well as in Sweden. We aimed to study excess deaths (all death causes, but also COVID-19-related deaths) during the COVID-19 pandemic regarding age, socio-economic status, the situation in nursing homes, and place of death for nursing home residents.\r\n\r\nWe performed a descriptive regional registry data study using VAL, the Stockholm Regional Council's central data warehouse, which covers almost all health care use in the county of Stockholm. T tests and chi-square tests were used for comparisons.\r\n\r\nCompared with 2016-2019, there were excess deaths in March-May 2020 ( p < 0.0001), mainly explained by COVID-19, but in April there were also unexplained excess deaths. Individuals dying from COVID-19 were older than patients dying from other causes (p < 0.0001). There were more patient deaths among people residing in less advantaged socio-economic areas (p < 0.0001). Nursing home residents dying from COVID-19 were more often admitted to acute hospitals than residents dying from other causes (p < 0.0001). Also, the proportion of admissions of nursing home residents dying from other causes increased from April to May 2020 (p < 0.0001).\r\n\r\nDying from COVID-19 mainly affects the elderly, nursing home residents, and persons from less advantaged socio-economic groups. The pandemic has resulted in an increase in acute admissions of dying nursing home residents to acute hospitals.", "doi": "10.1080/03009734.2020.1828513", "pmid": "33100083", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7594844"}], "notes": [], "created": "2020-12-01T15:28:20.193Z", "modified": "2022-11-09T08:34:37.083Z"}, {"entity": "publication", "iuid": "60ce9a3171084603b2c06be19e4deb20", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60ce9a3171084603b2c06be19e4deb20.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60ce9a3171084603b2c06be19e4deb20"}}, "title": "Estimation of global case fatality rate of coronavirus disease 2019 (COVID-19) using meta-analyses: Comparison between calendar date and days since the outbreak of the first confirmed case.", "authors": [{"family": "Ghayda", "given": "Ramy Abou", "initials": "RA"}, {"family": "Lee", "given": "Keum Hwa", "initials": "KH"}, {"family": "Han", "given": "Young Joo", "initials": "YJ"}, {"family": "Ryu", "given": "Seohyun", "initials": "S"}, {"family": "Hong", "given": "Sung Hwi", "initials": "SH"}, {"family": "Yoon", "given": "Sojung", "initials": "S"}, {"family": "Jeong", "given": "Gwang Hun", "initials": "GH"}, {"family": "Lee", "given": "Jinhee", "initials": "J"}, {"family": "Lee", "given": "Jun Young", "initials": "JY"}, {"family": "Yang", "given": "Jae Won", "initials": "JW"}, {"family": "Effenberger", "given": "Maria", "initials": "M"}, {"family": "Eisenhut", "given": "Michael", "initials": "M"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Solmi", "given": "Marco", "initials": "M"}, {"family": "Li", "given": "Han", "initials": "H"}, {"family": "Jacob", "given": "Louis", "initials": "L"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Shin", "given": "Jae Il", "initials": "JI"}, {"family": "Smith", "given": "Lee", "initials": "L"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "volume": "100", "issue": null, "pages": "302-308", "issn-l": "1201-9712"}, "abstract": "Since the outbreak of the coronavirus disease 2019 (COVID-19) in December of 2019 in China, estimating the pandemic's case fatality rate (CFR) has been the focus and interest of many stakeholders. In this manuscript, we prove that the method of using the cumulative CFR is static and does not reflect the trend according to the daily change per unit of time.\n\nA proportion meta-analysis was carried out on the CFR in every country reporting COVID-19 cases. Based on these results, we performed a meta-analysis for a global COVID-19 CFR. Each analysis was performed using two different calculations of CFR: according to the calendar date and according to the days since the outbreak of the first confirmed case. We thus explored an innovative and original calculation of CFR, concurrently based on the date of the first confirmed case as well as on a daily basis.\n\nFor the first time, we showed that using meta-analyses according to the calendar date and days since the outbreak of the first confirmed case, were different.\n\nWe propose that a CFR according to days since the outbreak of the first confirmed case might be a better predictor of the current CFR of COVID-19 and its kinetics.", "doi": "10.1016/j.ijid.2020.08.065", "pmid": "32882434", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(20)30694-9"}, {"db": "pmc", "key": "PMC7462556"}], "notes": [], "created": "2020-12-06T07:31:00.699Z", "modified": "2021-02-26T08:46:13.165Z"}, {"entity": "publication", "iuid": "f1cbe1efc1c1422ca2c02154a1dd7af5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1cbe1efc1c1422ca2c02154a1dd7af5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1cbe1efc1c1422ca2c02154a1dd7af5"}}, "title": "Establishment of a high-dependency unit in Malawi.", "authors": [{"family": "Morton", "given": "Ben", "initials": "B"}, {"family": "Banda", "given": "Ndaziona Peter", "initials": "NP"}, {"family": "Nsomba", "given": "Edna", "initials": "E"}, {"family": "Ngoliwa", "given": "Clara", "initials": "C"}, {"family": "Antoine", "given": "Sandra", "initials": "S"}, {"family": "Gondwe", "given": "Joel", "initials": "J"}, {"family": "Limbani", "given": "Felix", "initials": "F"}, {"family": "Henrion", "given": "Marc Yves Romain", "initials": "MYR"}, {"family": "Chirombo", "given": "James", "initials": "J"}, {"family": "Baker", "given": "Tim", "initials": "T"}, {"family": "Kamalo", "given": "Patrick", "initials": "P"}, {"family": "Phiri", "given": "Chimota", "initials": "C"}, {"family": "Masamba", "given": "Leo", "initials": "L"}, {"family": "Phiri", "given": "Tamara", "initials": "T"}, {"family": "Mallewa", "given": "Jane", "initials": "J"}, {"family": "Mwandumba", "given": "Henry Charles", "initials": "HC"}, {"family": "Mndolo", "given": "Kwazizira Samson", "initials": "KS"}, {"family": "Gordon", "given": "Stephen", "initials": "S"}, {"family": "Rylance", "given": "Jamie", "initials": "J"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "5", "issue": "11", "issn-l": "2059-7908"}, "abstract": "Adults admitted to hospital with critical illness are vulnerable and at high risk of morbidity and mortality, especially in sub-Saharan African settings where resources are severely limited. As life expectancy increases, patient demographics and healthcare needs are increasingly complex and require integrated approaches. Patient outcomes could be improved by increased critical care provision that standardises healthcare delivery, provides specialist staff and enhanced patient monitoring and facilitates some treatment modalities for organ support. In Malawi, we established a new high-dependency unit within Queen Elizabeth Central Hospital, a tertiary referral centre serving the country's Southern region. This unit was designed in partnership with managers, clinicians, nurses and patients to address their needs. In this practice piece, we describe a participatory approach to design and implement a sustainable high-dependency unit for a low-income sub-Saharan African setting. This included: prospective agreement on remit, alignment with existing services, refurbishment of a dedicated physical space, recruitment and training of specialist nurses, development of context-sensitive clinical standard operating procedures, purchase of appropriate and durable equipment and creation of digital clinical information systems. As the global COVID-19 pandemic unfolded, we accelerated unit opening in anticipation of increased clinical requirement and describe how the high-dependency unit responded to this demand.", "doi": "10.1136/bmjgh-2020-004041", "pmid": "33214176", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-004041"}], "notes": [], "created": "2020-11-26T12:32:03.207Z", "modified": "2020-11-26T12:32:03.217Z"}, {"entity": "publication", "iuid": "b0eb6187940d41ffbfe6bc0ce016018e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b0eb6187940d41ffbfe6bc0ce016018e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b0eb6187940d41ffbfe6bc0ce016018e"}}, "title": "Early impact of COVID-19 on individuals with self-reported eating disorders: A survey of ~1,000 individuals in the United States and the Netherlands.", "authors": [{"family": "Termorshuizen", "given": "Jet D", "initials": "JD"}, {"family": "Watson", "given": "Hunna J", "initials": "HJ"}, {"family": "Thornton", "given": "Laura M", "initials": "LM"}, {"family": "Borg", "given": "Stina", "initials": "S"}, {"family": "Flatt", "given": "Rachael E", "initials": "RE"}, {"family": "MacDermod", "given": "Casey M", "initials": "CM"}, {"family": "Harper", "given": "Lauren E", "initials": "LE"}, {"family": "van Furth", "given": "Eric F", "initials": "EF"}, {"family": "Peat", "given": "Christine M", "initials": "CM"}, {"family": "Bulik", "given": "Cynthia M", "initials": "CM"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Int J Eat Disord", "issn": "1098-108X", "issn-l": null, "volume": "53", "issue": "11", "pages": "1780-1790"}, "abstract": "We evaluated the early impact of COVID-19 on people with self-reported eating disorders.\r\n\r\nParticipants in the United States (US, N = 511) and the Netherlands (NL, N = 510), recruited through ongoing studies and social media, completed an online survey that included both quantitative measures and free-text responses assessing the impact of COVID-19 on situational circumstances, eating disorder symptoms, eating disorder treatment, and general well-being.\r\n\r\nResults revealed strong and wide-ranging effects on eating disorder concerns and illness behaviors that were consistent with eating disorder type. Participants with anorexia nervosa (US 62% of sample; NL 69%) reported increased restriction and fears about being able to find foods consistent with their meal plan. Individuals with bulimia nervosa and binge-eating disorder (US 30% of sample; NL 15%) reported increases in their binge-eating episodes and urges to binge. Respondents noted marked increases in anxiety since 2019 and reported greater concerns about the impact of COVID-19 on their mental health than physical health. Although many participants acknowledged and appreciated the transition to telehealth, limitations of this treatment modality for this population were raised. Individuals with past histories of eating disorders noted concerns about relapse related to COVID-19 circumstances. Encouragingly, respondents also noted positive effects including greater connection with family, more time for self-care, and motivation to recover.\r\n\r\nCOVID-19 is associated with increased anxiety and poses specific disorder-related challenges for individuals with eating disorders that require attention by healthcare professionals and carers.", "doi": "10.1002/eat.23353", "pmid": "32720399", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-07T16:11:16.707Z", "modified": "2022-11-09T08:36:27.009Z"}, {"entity": "publication", "iuid": "9bfe22c6f8c743c580a6feed3b78f8eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9bfe22c6f8c743c580a6feed3b78f8eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9bfe22c6f8c743c580a6feed3b78f8eb"}}, "title": "Do point-of-care tests (POCTs) offer a new paradigm for the management of patients with influenza?", "authors": [{"family": "Dickson", "given": "Elizabeth M", "initials": "EM"}, {"family": "Zambon", "given": "Maria", "initials": "M"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "de Lusignan", "given": "Simon", "initials": "S"}, {"family": "Elliot", "given": "Alex J", "initials": "AJ"}, {"family": "Ellis", "given": "Joanna", "initials": "J"}, {"family": "Lackenby", "given": "Angie", "initials": "A"}, {"family": "Smith", "given": "Gillian", "initials": "G"}, {"family": "McMenamin", "given": "Jim", "initials": "J"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "44", "issn-l": null}, "abstract": "The introduction of point-of-care tests (POCTs) has presented new opportunities for the management of patients presenting to healthcare providers with acute respiratory symptoms. This Perspective article is based on the experiences of national infection teams/those managing acute respiratory infections across the United Kingdom in terms of the challenges and opportunities that this may present for public health. This Perspective article was conceived and written pre-coronavirus disease (COVID-19), however the principles we outline here for influenza can also be translated to COVID-19 and some key points are made throughout the article. The greatest challenge for intergrating POCTs into non-traditional environments is the capture of data and samples for surveillance purposes which provides information for public health action. However, POCTs together with measures outlined in this article, offer a new paradigm for the management and public health surveillance of patients with influenza.", "doi": "10.2807/1560-7917.ES.2020.25.44.1900420", "pmid": "33153522", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7645971"}], "notes": [], "created": "2020-12-01T14:46:59.334Z", "modified": "2020-12-01T14:46:59.344Z"}, {"entity": "publication", "iuid": "83ed1f8cf17b401996eda78f45153f36", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/83ed1f8cf17b401996eda78f45153f36.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/83ed1f8cf17b401996eda78f45153f36"}}, "title": "Did location-based games motivate players to socialize during COVID-19?", "authors": [{"family": "Laato", "given": "Samuli", "initials": "S"}, {"family": "Islam", "given": "A K M Najmul", "initials": "AKMN"}, {"family": "Laine", "given": "Teemu H", "initials": "TH"}], "type": "journal-article", "published": "2020-11-00", "journal": {"title": "Telematics and Informatics", "issn": "0736-5853", "issn-l": null, "volume": "54", "issue": null, "pages": "101458"}, "abstract": null, "doi": "10.1016/j.tele.2020.101458", "pmid": null, "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:54:26.640Z", "modified": "2022-11-09T08:38:07.029Z"}, {"entity": "publication", "iuid": "7509e78a75f94b1283539b1fe33942d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7509e78a75f94b1283539b1fe33942d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7509e78a75f94b1283539b1fe33942d7"}}, "title": "Covid-19 in kidney transplant recipients: a systematic review of the case series available three months into the pandemic.", "authors": [{"family": "Oltean", "given": "Mihai", "initials": "M"}, {"family": "S\u00f8fteland", "given": "John Mackay", "initials": "JM"}, {"family": "Bagge", "given": "Jasmine", "initials": "J"}, {"family": "Ekelund", "given": "Jan", "initials": "J"}, {"family": "Felldin", "given": "Marie", "initials": "M"}, {"family": "Schult", "given": "Andreas", "initials": "A"}, {"family": "Magnusson", "given": "Jesper", "initials": "J"}, {"family": "Friman", "given": "Vanda", "initials": "V"}, {"family": "Karason", "given": "Kristjan", "initials": "K"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "volume": "52", "issue": "11", "pages": "830-837", "issn-l": "2374-4235"}, "abstract": "Coronavirus disease 2019 (COVID-19) ranges from a mild illness to acute respiratory distress syndrome (ARDS), multiorgan dysfunction, and death. Transplant recipients are vulnerable due to comorbidities and immunosuppressants that render them susceptible to infections. The information on COVID-19 in kidney transplant recipients remains limited to small case series.\n\nA systematic literature search was conducted, and 12 case series totalling 204 kidney transplant recipients with COVID-19 were identified. Data were extracted, pooled and analysed.\n\nMost patients (74%) were men. The most frequent symptoms were fever (76%), cough (64%) and dyspnoea (43%). At admission, over 70% of the patients had abnormal radiological findings. Leukocyte counts were in the lower normal range. C-reactive protein, ferritin, and D-dimer were consistently increased. Treatments included lowering immunosuppression, hydroxychloroquine, antivirals, tocilizumab and intravenous immunoglobulins. Thirty-one percent of the patients were admitted to intensive care units (ICUs), and 16% required intubation. The overall mortality was 21.2%. Patients who died were significantly older than those who survived (61 \u00b1 12 vs. 51 \u00b1 15, p < .01). Logistic regression revealed that the odds for death increased by 4.3% for each additional year of age (odds ratio [OR] 1.043, 95% confidence interval [CI] 1.005-1.083, p value = .0265).\n\nNo substantial conclusions could be drawn on the efficacy of any particular treatment. More rigorous patient stratification is needed when analysing and reporting data to facilitate future meta-analyses.", "doi": "10.1080/23744235.2020.1792977", "pmid": "32657186", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-30T08:51:24.300Z", "modified": "2020-12-08T14:14:19.150Z"}, {"entity": "publication", "iuid": "a3e7cb41d6e1464a9318407386ba4762", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3e7cb41d6e1464a9318407386ba4762.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3e7cb41d6e1464a9318407386ba4762"}}, "title": "Converging pathways in pulmonary fibrosis and Covid-19 - The fibrotic link to disease severity.", "authors": [{"family": "Wig\u00e9n", "given": "Jenny", "initials": "J"}, {"family": "L\u00f6fdahl", "given": "Anna", "initials": "A"}, {"family": "Bjermer", "given": "Leif", "initials": "L"}, {"family": "Elowsson-Rendin", "given": "Linda", "initials": "L"}, {"family": "Westergren-Thorsson", "given": "Gunilla", "initials": "G"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Respir Med X", "issn": "2590-1435", "volume": "2", "issue": null, "pages": "100023", "issn-l": "2590-1435"}, "abstract": "As Covid-19 affects millions of people worldwide, the global health care will encounter an increasing burden of the aftermaths of the disease. Evidence shows that up to a fifth of the patients develop fibrotic tissue in the lung. The SARS outbreak in the early 2000 resulted in chronic pulmonary fibrosis in a subset (around 4%) of the patients, and correlated to reduced lung function and forced expiratory volume (FEV). The similarities between corona virus infections causing SARS and Covid-19 are striking, except that the novel coronavirus, SARS-CoV-2, has proven to have an even higher communicability. This would translate into a large number of patients seeking care for clinical signs of pulmonary fibrosis, given that the Covid-19 pandemic has up till now (Sept 2020) affected around 30 million people. The SARS-CoV-2 is dependent on binding to the angiotensin converting enzyme 2 (ACE2), which is part of the renin-angiotensin system (RAS). Downregulation of ACE2 upon virus binding disturbs downstream activities of RAS resulting in increased inflammation and development of fibrosis. The poor prognosis and risk of developing pulmonary fibrosis are therefore associated with the increased expression of ACE2 in risk groups, such as obesity, heart disorders and aging, conferring plenty of binding opportunity for the virus and subsequently the internalization of ACE2, thus devoiding the enzyme from acting counter-inflammatory and antifibrotic. Identifying pathways that are associated with Covid-19 severity that result in pulmonary fibrosis may enable early diagnosis and individualized treatment for these patients to prevent or reduce irreversible fibrotic damage to the lung.", "doi": "10.1016/j.yrmex.2020.100023", "pmid": "33083782", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2590-1435(20)30010-5"}, {"db": "pmc", "key": "PMC7546672"}], "notes": [], "created": "2020-11-27T11:49:56.303Z", "modified": "2020-11-27T11:49:56.325Z"}, {"entity": "publication", "iuid": "6444d78ee37f4160adc32e3a9816b527", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6444d78ee37f4160adc32e3a9816b527.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6444d78ee37f4160adc32e3a9816b527"}}, "title": "Considerations on biologicals for patients with allergic disease in times of the COVID-19 pandemic: An EAACI statement.", "authors": [{"family": "Vultaggio", "given": "Alessandra", "initials": "A"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Akdis", "given": "Cezmi A", "initials": "CA"}, {"family": "Akdis", "given": "Mubeccel", "initials": "M"}, {"family": "Bavbek", "given": "Sevim", "initials": "S"}, {"family": "Bossios", "given": "Apostolos", "initials": "A"}, {"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Boyman", "given": "Onur", "initials": "O"}, {"family": "Chaker", "given": "Adam M", "initials": "AM"}, {"family": "Chan", "given": "Susan", "initials": "S"}, {"family": "Chatzipetrou", "given": "Alexia", "initials": "A"}, {"family": "Feleszko", "given": "Wojciech", "initials": "W"}, {"family": "Firinu", "given": "Davide", "initials": "D"}, {"family": "Jutel", "given": "Marek", "initials": "M"}, {"family": "Kauppi", "given": "Paula", "initials": "P"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Kolios", "given": "Antonios", "initials": "A"}, {"family": "Kothari", "given": "Akash", "initials": "A"}, {"family": "Kowalski", "given": "Marek L", "initials": "ML"}, {"family": "Matucci", "given": "Andrea", "initials": "A"}, {"family": "Palomares", "given": "Oscar", "initials": "O"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Rogala", "given": "Barbara", "initials": "B"}, {"family": "Untersmayr", "given": "Eva", "initials": "E"}, {"family": "Eiwegger", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Allergy", "issn": "1398-9995", "issn-l": "0105-4538", "volume": "75", "issue": "11", "pages": "2764-2774"}, "abstract": "The outbreak of the SARS-CoV-2-induced coronavirus disease 2019 (COVID-19) pandemic re-shaped doctor-patient interaction and challenged capacities of healthcare systems. It created many issues around the optimal and safest way to treat complex patients with severe allergic disease. A significant number of the patients are on treatment with biologicals, and clinicians face the challenge to provide optimal care during the pandemic. Uncertainty of the potential risks for these patients is related to the fact that the exact sequence of immunological events during SARS-CoV-2 is not known. Severe COVID-19 patients may experience a \"cytokine storm\" and associated organ damage characterized by an exaggerated release of pro-inflammatory type 1 and type 3 cytokines. These inflammatory responses are potentially counteracted by anti-inflammatory cytokines and type 2 responses. This expert-based EAACI statement aims to provide guidance on the application of biologicals targeting type 2 inflammation in patients with allergic disease. Currently, there is very little evidence for an enhanced risk of patients with allergic diseases to develop severe COVID-19. Studies focusing on severe allergic phenotypes are lacking. At present, noninfected patients on biologicals for the treatment of asthma, atopic dermatitis, chronic rhinosinusitis with nasal polyps, or chronic spontaneous urticaria should continue their biologicals targeting type 2 inflammation via self-application. In case of an active SARS-CoV-2 infection, biological treatment needs to be stopped until clinical recovery and SARS-CoV-2 negativity is established and treatment with biologicals should be re-initiated. Maintenance of add-on therapy and a constant assessment of disease control, apart from acute management, are demanded.", "doi": "10.1111/all.14407", "pmid": "32500526", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7300800"}], "notes": [], "created": "2020-12-09T10:37:02.018Z", "modified": "2020-12-11T12:45:39.347Z"}, {"entity": "publication", "iuid": "c16a784427d3471e850b91eee6e6a91d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c16a784427d3471e850b91eee6e6a91d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c16a784427d3471e850b91eee6e6a91d"}}, "title": "Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy.", "authors": [{"family": "Mastellos", "given": "Dimitrios C", "initials": "DC"}, {"family": "Pires da Silva", "given": "Bruno G P", "initials": "BGP"}, {"family": "Fonseca", "given": "Benedito A L", "initials": "BAL"}, {"family": "Fonseca", "given": "Natasha P", "initials": "NP"}, {"family": "Auxiliadora-Martins", "given": "Maria", "initials": "M"}, {"family": "Mastaglio", "given": "Sara", "initials": "S"}, {"family": "Ruggeri", "given": "Annalisa", "initials": "A"}, {"family": "Sironi", "given": "Marina", "initials": "M"}, {"family": "Radermacher", "given": "Peter", "initials": "P"}, {"family": "Chrysanthopoulou", "given": "Akrivi", "initials": "A"}, {"family": "Skendros", "given": "Panagiotis", "initials": "P"}, {"family": "Ritis", "given": "Konstantinos", "initials": "K"}, {"family": "Manfra", "given": "Ilenia", "initials": "I"}, {"family": "Iacobelli", "given": "Simona", "initials": "S"}, {"family": "Huber-Lang", "given": "Markus", "initials": "M"}, {"family": "Nilsson", "given": "Bo", "initials": "B"}, {"family": "Yancopoulou", "given": "Despina", "initials": "D"}, {"family": "Connolly", "given": "E Sander", "initials": "ES"}, {"family": "Garlanda", "given": "Cecilia", "initials": "C"}, {"family": "Ciceri", "given": "Fabio", "initials": "F"}, {"family": "Risitano", "given": "Antonio M", "initials": "AM"}, {"family": "Calado", "given": "Rodrigo T", "initials": "RT"}, {"family": "Lambris", "given": "John D", "initials": "JD"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Clin Immunol", "issn": "1521-7035", "issn-l": "1521-6616", "volume": "220", "issue": null, "pages": "108598"}, "abstract": "Growing clinical evidence has implicated complement as a pivotal driver of COVID-19 immunopathology. Deregulated complement activation may fuel cytokine-driven hyper-inflammation, thrombotic microangiopathy and NET-driven immunothrombosis, thereby leading to multi-organ failure. Complement therapeutics have gained traction as candidate drugs for countering the detrimental consequences of SARS-CoV-2 infection. Whether blockade of terminal complement effectors (C5, C5a, or C5aR1) may elicit similar outcomes to upstream intervention at the level of C3 remains debated. Here we compare the efficacy of the C5-targeting monoclonal antibody eculizumab with that of the compstatin-based C3-targeted drug candidate AMY-101 in small independent cohorts of severe COVID-19 patients. Our exploratory study indicates that therapeutic complement inhibition abrogates COVID-19 hyper-inflammation. Both C3 and C5 inhibitors elicit a robust anti-inflammatory response, reflected by a steep decline in C-reactive protein and IL-6 levels, marked lung function improvement, and resolution of SARS-CoV-2-associated acute respiratory distress syndrome (ARDS). C3 inhibition afforded broader therapeutic control in COVID-19 patients by attenuating both C3a and sC5b-9 generation and preventing FB consumption. This broader inhibitory profile was associated with a more robust decline of neutrophil counts, attenuated neutrophil extracellular trap (NET) release, faster serum LDH decline, and more prominent lymphocyte recovery. These early clinical results offer important insights into the differential mechanistic basis and underlying biology of C3 and C5 inhibition in COVID-19 and point to a broader pathogenic involvement of C3-mediated pathways in thromboinflammation. They also support the evaluation of these complement-targeting agents as COVID-19 therapeutics in large prospective trials.", "doi": "10.1016/j.clim.2020.108598", "pmid": "32961333", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1521-6616(20)30758-0"}, {"db": "pmc", "key": "PMC7501834"}, {"db": "mid", "key": "NIHMS1630767"}], "notes": [], "created": "2020-11-22T09:51:36.660Z", "modified": "2021-02-26T08:45:48.658Z"}, {"entity": "publication", "iuid": "7618b0b3be3a4654afdfe602c1f37d89", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7618b0b3be3a4654afdfe602c1f37d89.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7618b0b3be3a4654afdfe602c1f37d89"}}, "title": "Cell-based therapies for coronavirus disease 2019: proper clinical investigations are essential.", "authors": [{"family": "Khoury", "given": "Maroun", "initials": "M"}, {"family": "Rocco", "given": "Patricia R M", "initials": "PRM"}, {"family": "Phinney", "given": "Donald G", "initials": "DG"}, {"family": "Krampera", "given": "Mauro", "initials": "M"}, {"family": "Martin", "given": "Ivan", "initials": "I"}, {"family": "Viswanathan", "given": "Sowmya", "initials": "S"}, {"family": "Nolta", "given": "Jan A", "initials": "JA"}, {"family": "LeBlanc", "given": "Katarina", "initials": "K"}, {"family": "Galipeau", "given": "Jacques", "initials": "J"}, {"family": "Weiss", "given": "Daniel J", "initials": "DJ"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Cytotherapy", "issn": "1477-2566", "volume": "22", "issue": "11", "pages": "602-605", "issn-l": "1465-3249"}, "abstract": "The serious consequences of the global coronavirus disease 2019 (COVID-19) pandemic have prompted a rapid global response to develop effective therapies that can lessen disease severity in infected patients. Cell-based approaches, primarily using mesenchymal stromal cells (MSCs), have demonstrated a strong safety profile and possible efficacy in patients with acute respiratory distress syndrome (ARDS), but whether these therapies are effective for treating respiratory virus-induced ARDS is unknown. According to the World Health Organization International Clinical Trials Registry Platform and the National Institutes of Health ClinicalTrials.gov databases, 27 clinical investigations of MSC-based cell therapy approaches have begun in China since the onset of the COVID-19 outbreak, with a growing number of academic and industry trials elsewhere as well. Several recent published reports have suggested potential efficacy; however, the available data presented are either anecdotal or from incomplete, poorly controlled investigations. Therefore, although there may be a potential role for MSCs and other cell-based therapies in treatment of COVID-19, these need to be investigated in a rationally designed, controlled approach if safety and efficacy are to be demonstrated accurately. The authors urge that the field proceed by finding a balance between swift experimentation and communication of results and scientifically coherent generation and analysis of clinical data.", "doi": "10.1016/j.jcyt.2020.04.089", "pmid": "32933835", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1465-3249(20)30616-2"}, {"db": "pmc", "key": "PMC7163352"}], "notes": [], "created": "2020-11-26T12:31:43.302Z", "modified": "2020-12-03T15:32:34.772Z"}, {"entity": "publication", "iuid": "ef5fe45bee7c4605946def64196f45a3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef5fe45bee7c4605946def64196f45a3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef5fe45bee7c4605946def64196f45a3"}}, "title": "Can hyperbaric oxygen safely serve as an anti-inflammatory treatment for COVID-19?", "authors": [{"family": "Kjellberg", "given": "Anders", "initials": "A"}, {"family": "De Maio", "given": "Antonio", "initials": "A"}, {"family": "Lindholm", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Med Hypotheses", "issn": "1532-2777", "volume": "144", "issue": null, "pages": "110224", "issn-l": null}, "abstract": "SARS-CoV-2 affects part of the innate immune response and activates an inflammatory cascade stimulating the release of cytokines and chemokines, particularly within the lung. Indeed, the inflammatory response during COVID-19 is likely the cause for the development of acute respiratory distress syndrome (ARDS). Patients with mild symptoms also show significant changes on pulmonary CT-scan suggestive of severe inflammatory involvement.\n\nThe overall hypothesis is that HBO 2 is safe and reduces the inflammatory response in COVID-19 pneumonitis by attenuation of the innate immune system, increase hypoxia tolerance and thereby prevent organ failure and reduce mortality.\n\nHBO 2 is used in clinical practice to treat inflammatory conditions but has not been scientifically evaluated for COVID-19. Experimental and empirical data suggests that HBO2 may reduce inflammatory response in COVID-19. However, there are concerns regarding pulmonary safety in patients with pre-existing viral pneumonitis.\n\nAnecdotes from \"compassionate use\" and two published case reports show promising results.\n\nSmall prospective clinical trials are on the way and we are conducting a randomized clinical trial.", "doi": "10.1016/j.mehy.2020.110224", "pmid": "33254531", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0306-9877(20)31444-4"}], "notes": [], "created": "2020-12-03T08:22:26.149Z", "modified": "2020-12-03T08:23:38.944Z"}, {"entity": "publication", "iuid": "2ed302c1d9094ee7a8728af4c143f3f6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ed302c1d9094ee7a8728af4c143f3f6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ed302c1d9094ee7a8728af4c143f3f6"}}, "title": "COVID-19: risk accumulation among biologically and socially vulnerable older populations.", "authors": [{"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A"}, {"family": "Dekhtyar", "given": "Serhiy", "initials": "S"}, {"family": "Vetrano", "given": "Davide L", "initials": "DL"}, {"family": "Bellander", "given": "Tom", "initials": "T"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Ageing Res Rev", "issn": "1872-9649", "issn-l": "1568-1637", "volume": "63", "issue": null, "pages": "101149"}, "abstract": "Emerging data show that the health and economic impacts of COVID-19 are being disproportionately borne by individuals who are not only biologically, but also socially vulnerable. Based on preliminary data from Sweden and other reports, in this paper we propose a conceptual framework whereby different factors related to biological and social vulnerability may explain the specific COVID-19 burden among older people. There is already some evidence showing large social disparities in the prevention, treatment, prognosis and/or long-term consequences of COVID-19. The remaining question is to what extent these affect older adults specifically. We provide the rationale to address this question with scientific methods and proper study designs, where the interplay between individuals' biomedical status and their social environment is the focus. Only through interdisciplinary research integrating biological, clinical and social data will we be able to provide new insights into the SARS-CoV-2 pandemic and inform actions aimed at reducing older adults' vulnerability to COVID-19 or other similar pandemics in the future.", "doi": "10.1016/j.arr.2020.101149", "pmid": "32818650", "labels": {"Type: Journal article": null, "Topics: Register-based research": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7430278"}, {"db": "pii", "key": "S1568-1637(20)30284-1"}], "notes": [], "created": "2020-11-26T12:20:00.368Z", "modified": "2023-06-19T15:29:09.387Z"}, {"entity": "publication", "iuid": "e3eaabbfa0ec451b8202ccdb29c1d375", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3eaabbfa0ec451b8202ccdb29c1d375.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3eaabbfa0ec451b8202ccdb29c1d375"}}, "title": "COVID-19: minimising contaminated aerosol spreading during CPAP treatment.", "authors": [{"family": "Donaldsson", "given": "Snorri", "initials": "S"}, {"family": "Naver", "given": "Lars", "initials": "L"}, {"family": "Jonsson", "given": "Baldvin", "initials": "B"}, {"family": "Drevhammar", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Arch Dis Child Fetal Neonatal Ed", "issn": "1468-2052", "issn-l": null, "volume": "105", "issue": "6", "pages": "669-671"}, "abstract": "The COVID-19 pandemic has raised concern for healthcare workers getting infected via aerosol from non-invasive respiratory support of infants. Attaching filters that remove viral particles in air from the expiratory limb of continuous positive airway pressure (CPAP) devices should theoretically decrease the risk. However, adding filters to the expiratory limb could add to expiratory resistance and thereby increase the imposed work of breathing (WOB).\r\n\r\nTo evaluate the effects on imposed WOB when attaching filters to the expiratory limb of CPAP devices.\r\n\r\nTwo filters were tested on three CPAP systems at two levels of CPAP in a mechanical lung model. Main outcome was imposed WOB.\r\n\r\nThere was a minor increase in imposed WOB when attaching the filters. The differences between the two filters were small.\r\n\r\nTo minimise contaminated aerosol generation during CPAP treatment, filters can be attached to expiratory tubing with only a minimal increase in imposed WOB in a non-humidified environment. Care has to be taken to avoid filter obstruction and replace filters as recommended.", "doi": "10.1136/archdischild-2020-319431", "pmid": "32669360", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "archdischild-2020-319431"}], "notes": [], "created": "2020-12-07T16:37:43.317Z", "modified": "2021-02-26T08:46:13.555Z"}, {"entity": "publication", "iuid": "7b7fc3cac0ab460f8c23c8110677303f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b7fc3cac0ab460f8c23c8110677303f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b7fc3cac0ab460f8c23c8110677303f"}}, "title": "COVID-19: The immediate response of european academic dental institutions and future implications for dental education.", "authors": [{"family": "Quinn", "given": "Barry", "initials": "B"}, {"family": "Field", "given": "James", "initials": "J"}, {"family": "Gorter", "given": "Ronald", "initials": "R"}, {"family": "Akota", "given": "Ilze", "initials": "I"}, {"family": "Manzanares", "given": "Maria-Cristina", "initials": "MC"}, {"family": "Paganelli", "given": "Corrado", "initials": "C"}, {"family": "Davies", "given": "Julia", "initials": "J"}, {"family": "Dixon", "given": "Jonathan", "initials": "J"}, {"family": "Gabor", "given": "Gerber", "initials": "G"}, {"family": "Amaral Mendes", "given": "Rui", "initials": "R"}, {"family": "Hahn", "given": "Petra", "initials": "P"}, {"family": "Vital", "given": "Sibylle", "initials": "S"}, {"family": "O'Brien", "given": "Judith", "initials": "J"}, {"family": "Murphy", "given": "Denis", "initials": "D"}, {"family": "Tubert-Jeannin", "given": "St\u00e9phanie", "initials": "S"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Eur J Dent Educ", "issn": "1600-0579", "volume": "24", "issue": "4", "pages": "811-814", "issn-l": null}, "abstract": "The COVID-19 pandemic has had an immediate and dramatic impact on dental education. The Association of Dental Education in Europe decided to carry out an investigation to assess the immediate response of European Academic Dental Institutions. An online survey was sent to both member and non-member dental schools to investigate the impact on non-clinical and clinical education, assessment and the well-being/pastoral care measures implemented. The preliminary findings and discussion are presented in this paper, for the responses collected between the 25 March and 5 April 2020. The survey at this time of publication is ongoing, and detailed results can be accessed https://adee.org/covid-19-european-dental-education%E2%80%99s-immediate-response.", "doi": "10.1111/eje.12542", "pmid": "32394605", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7272881"}], "notes": [], "created": "2020-12-10T08:39:33.398Z", "modified": "2021-02-26T08:45:48.363Z"}, {"entity": "publication", "iuid": "c7b5d0c782d34b6b8e7f92788ee11cde", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7b5d0c782d34b6b8e7f92788ee11cde.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7b5d0c782d34b6b8e7f92788ee11cde"}}, "title": "COVID-19 puts the Sustainable Development Goals center stage.", "authors": [{"family": "Ottersen", "given": "Ole Petter", "initials": "OP"}, {"family": "Engebretsen", "given": "Eivind", "initials": "E"}], "type": "letter", "published": "2020-11-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956", "volume": "26", "issue": "11", "pages": "1672-1673"}, "abstract": "Correspondence", "doi": "10.1038/s41591-020-1094-y", "pmid": "33037423", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-020-1094-y"}], "notes": [], "created": "2020-12-01T17:24:14.636Z", "modified": "2020-12-01T17:24:43.108Z"}, {"entity": "publication", "iuid": "ed9e198eee0a4b77a10da7df00a85602", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed9e198eee0a4b77a10da7df00a85602.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed9e198eee0a4b77a10da7df00a85602"}}, "title": "Age, Frailty, and Comorbidity as Prognostic Factors for Short-Term Outcomes in Patients With Coronavirus Disease 2019 in Geriatric Care.", "authors": [{"family": "H\u00e4gg", "given": "Sara", "initials": "S"}, {"family": "Jylh\u00e4v\u00e4", "given": "Juulia", "initials": "J"}, {"family": "Wang", "given": "Yunzhang", "initials": "Y"}, {"family": "Xu", "given": "Hong", "initials": "H"}, {"family": "Metzner", "given": "Carina", "initials": "C"}, {"family": "Annetorp", "given": "Martin", "initials": "M"}, {"family": "Garcia-Ptacek", "given": "Sara", "initials": "S"}, {"family": "Khedri", "given": "Masih", "initials": "M"}, {"family": "Bostr\u00f6m", "given": "Anne-Marie", "initials": "A"}, {"family": "Kadir", "given": "Ahmadul", "initials": "A"}, {"family": "Johansson", "given": "Anna", "initials": "A"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}, {"family": "Cederholm", "given": "Tommy", "initials": "T"}, {"family": "Religa", "given": "Dorota", "initials": "D"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "J Am Med Dir Assoc", "issn": "1538-9375", "issn-l": null, "volume": "21", "issue": "11", "pages": "1555-1559.e2"}, "abstract": "To analyze whether frailty and comorbidities are associated with in-hospital mortality and discharge to home in older adults hospitalized for coronavirus disease 2019 (COVID-19).\r\n\r\nSingle-center observational study.\r\n\r\nPatients admitted to geriatric care in a large hospital in Sweden between March 1 and June 11, 2020; 250 were treated for COVID-19 and 717 for other diagnoses.\r\n\r\nCOVID-19 diagnosis was clinically confirmed by positive reverse transcription polymerase chain reaction test or, if negative, by other methods. Patient data were extracted from electronic medical records, which included Clinical Frailty Scale (CFS), and were further used for assessments of the Hospital Frailty Risk Score (HFRS) and the Charlson Comorbidity Index (CCI). In-hospital mortality and home discharge were followed up for up to 25 and 28 days, respectively. Multivariate Cox regression models adjusted for age and sex were used.\r\n\r\nAmong the patients with COVID-19, in-hospital mortality rate was 24% and home discharge rate was 44%. Higher age was associated with in-hospital mortality (hazard ratio [HR] 1.05 per each year, 95% confidence interval [CI] 1.01\u20121.08) and lower probability of home discharge (HR 0.97, 95% CI 0.95\u20120.99). CFS (>5) and CCI, but not HFRS, were predictive of in-hospital mortality (HR 1.93, 95% CI 1.02\u20123.65 and HR 1.27, 95% CI 1.02\u20121.58, respectively). Patients with CFS >5 had a lower probability of being discharged home (HR 0.38, 95% CI 0.25\u20120.58). CCI and HFRS were not associated with home discharge. In general, effects were more pronounced in men. Acute kidney injury was associated with in-hospital mortality and hypertension with discharge to home. Other comorbidities (diabetes, cardiovascular disease, lung diseases, chronic kidney disease and dementia) were not associated with either outcome.\r\n\r\nOf all geriatric patients with COVID-19, 3 out of 4 survived during the study period. Our results indicate that in addition to age, the level of frailty is a useful predictor of short-term COVID-19 outcomes in geriatric patients.", "doi": "10.1016/j.jamda.2020.08.014", "pmid": "32978065", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S1525-8610(20)30704-0"}, {"db": "pmc", "key": "PMC7427570"}], "notes": [], "created": "2020-12-03T09:52:18.204Z", "modified": "2022-11-09T08:39:52.158Z"}, {"entity": "publication", "iuid": "7628ba6a3c0448c6a81d8b7127f04490", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7628ba6a3c0448c6a81d8b7127f04490.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7628ba6a3c0448c6a81d8b7127f04490"}}, "title": "Addressing Influenza Vaccination in MENA Region during the COVID-19 Pandemic: Decreasing the Effects of the Collision.", "authors": [{"family": "Al Awaidy", "given": "Salah T", "initials": "ST"}, {"family": "Uyaro\u011flu", "given": "O\u011fuz Abdullah", "initials": "OA"}, {"family": "Wannous", "given": "Chadia", "initials": "C"}, {"family": "Tanriover", "given": "Mine Durusu", "initials": "MD"}], "type": "editorial", "published": "2020-11-00", "journal": {"title": "Oman Med J", "issn": "1999-768X", "volume": "35", "issue": "6", "pages": "e200", "issn-l": null}, "abstract": "Editorial", "doi": "10.5001/omj.2020.132", "pmid": "33214914", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "OMJ-35-06-2000198"}, {"db": "pmc", "key": "PMC7653348"}], "notes": [], "created": "2020-11-27T10:42:01.106Z", "modified": "2020-11-27T10:42:29.251Z"}, {"entity": "publication", "iuid": "831466582e8c428088cfc333e39ab798", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/831466582e8c428088cfc333e39ab798.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/831466582e8c428088cfc333e39ab798"}}, "title": "Adapting care for older cancer patients during the COVID-19 pandemic: Recommendations from the International Society of Geriatric Oncology (SIOG) COVID-19 Working Group.", "authors": [{"family": "Battisti", "given": "Nicol\u00f2 Matteo Luca", "initials": "NML"}, {"family": "Mislang", "given": "Anna Rachelle", "initials": "AR"}, {"family": "Cooper", "given": "Lisa", "initials": "L"}, {"family": "O'Donovan", "given": "Anita", "initials": "A"}, {"family": "Audisio", "given": "Riccardo A", "initials": "RA"}, {"family": "Cheung", "given": "Kwok-Leung", "initials": "KL"}, {"family": "Sarri\u00f3", "given": "Regina Giron\u00e9s", "initials": "RG"}, {"family": "Stauder", "given": "Reinhard", "initials": "R"}, {"family": "Soto-Perez-de-Celis", "given": "Enrique", "initials": "E"}, {"family": "Jaklitsch", "given": "Michael", "initials": "M"}, {"family": "Williams", "given": "Grant R", "initials": "GR"}, {"family": "O'Hanlon", "given": "Shane", "initials": "S"}, {"family": "Alam", "given": "Mahmood", "initials": "M"}, {"family": "Cairo", "given": "Clarito", "initials": "C"}, {"family": "Colloca", "given": "Giuseppe", "initials": "G"}, {"family": "Gil", "given": "Luiz Antonio", "initials": "LA"}, {"family": "Sattar", "given": "Schroder", "initials": "S"}, {"family": "Kantilal", "given": "Kumud", "initials": "K"}, {"family": "Russo", "given": "Chiara", "initials": "C"}, {"family": "Lichtman", "given": "Stuart M", "initials": "SM"}, {"family": "Brain", "given": "Etienne", "initials": "E"}, {"family": "Kanesvaran", "given": "Ravindran", "initials": "R"}, {"family": "Wildiers", "given": "Hans", "initials": "H"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "J Geriatr Oncol", "issn": "1879-4076", "volume": "11", "issue": "8", "pages": "1190-1198", "issn-l": null}, "abstract": "The COVID-19 pandemic poses a barrier to equal and evidence-based management of cancer in older adults. The International Society of Geriatric Oncology (SIOG) formed a panel of experts to develop consensus recommendations on the implications of the pandemic on several aspects of cancer care in this age group including geriatric assessment (GA), surgery, radiotherapy, systemic treatment, palliative care and research. Age and cancer diagnosis are significant predictors of adverse outcomes of the COVID-19 infection. In this setting, GA is particularly valuable to drive decision-making. GA may aid estimating physiologic reserve and adaptive capability, assessing risk-benefits of either providing or temporarily withholding treatments, and determining patient preferences to help inform treatment decisions. In a resource-constrained setting, geriatric screening tools may be administered remotely to identify patients requiring comprehensive GA. Tele-health is also crucial to ensure adequate continuity of care and minimize the risk of infection exposure. In general, therapeutic decisions should favor the most effective and least invasive approach with the lowest risk of adverse outcomes. In selected cases, this might require deferring or omitting surgery, radiotherapy or systemic treatments especially where benefits are marginal and alternative safe therapeutic options are available. Ongoing research is necessary to expand knowledge of the management of cancer in older adults. However, the pandemic presents a significant barrier and efforts should be made to ensure equitable access to clinical trials and prospective data collection to elucidate the outcomes of COVID-19 in this population.", "doi": "10.1016/j.jgo.2020.07.008", "pmid": "32709495", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1879-4068(20)30366-0"}, {"db": "pmc", "key": "PMC7365054"}], "notes": [], "created": "2020-11-30T08:44:15.803Z", "modified": "2020-11-30T08:44:15.827Z"}, {"entity": "publication", "iuid": "fc398b4a001242a99d74b29f8994cd26", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc398b4a001242a99d74b29f8994cd26.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc398b4a001242a99d74b29f8994cd26"}}, "title": "ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study.", "authors": [{"family": "Gill", "given": "Dipender", "initials": "D"}, {"family": "Arvanitis", "given": "Marios", "initials": "M"}, {"family": "Carter", "given": "Paul", "initials": "P"}, {"family": "Hern\u00e1ndez Cordero", "given": "Ana I", "initials": "AI"}, {"family": "Jo", "given": "Brian", "initials": "B"}, {"family": "Karhunen", "given": "Ville", "initials": "V"}, {"family": "Larsson", "given": "Susanna C", "initials": "SC"}, {"family": "Li", "given": "Xuan", "initials": "X"}, {"family": "Lockhart", "given": "Sam M", "initials": "SM"}, {"family": "Mason", "given": "Amy", "initials": "A"}, {"family": "Pashos", "given": "Evanthia", "initials": "E"}, {"family": "Saha", "given": "Ashis", "initials": "A"}, {"family": "Tan", "given": "Vanessa Y", "initials": "VY"}, {"family": "Zuber", "given": "Verena", "initials": "V"}, {"family": "Boss\u00e9", "given": "Yohan", "initials": "Y"}, {"family": "Fahle", "given": "Sarah", "initials": "S"}, {"family": "Hao", "given": "Ke", "initials": "K"}, {"family": "Jiang", "given": "Tao", "initials": "T"}, {"family": "Joubert", "given": "Philippe", "initials": "P"}, {"family": "Lunt", "given": "Alan C", "initials": "AC"}, {"family": "Ouwehand", "given": "Willem Hendrik", "initials": "WH"}, {"family": "Roberts", "given": "David J", "initials": "DJ"}, {"family": "Timens", "given": "Wim", "initials": "W"}, {"family": "van den Berge", "given": "Maarten", "initials": "M"}, {"family": "Watkins", "given": "Nicholas A", "initials": "NA"}, {"family": "Battle", "given": "Alexis", "initials": "A"}, {"family": "Butterworth", "given": "Adam S", "initials": "AS"}, {"family": "Danesh", "given": "John", "initials": "J"}, {"family": "Di Angelantonio", "given": "Emanuele", "initials": "E"}, {"family": "Engelhardt", "given": "Barbara E", "initials": "BE"}, {"family": "Peters", "given": "James E", "initials": "JE"}, {"family": "Sin", "given": "Don D", "initials": "DD"}, {"family": "Burgess", "given": "Stephen", "initials": "S"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "R Soc Open Sci", "issn": "2054-5703", "issn-l": null, "volume": "7", "issue": "11", "pages": "200958"}, "abstract": "Angiotensin-converting enzyme 2 (ACE2) and serine protease TMPRSS2 have been implicated in cell entry for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). The expression of ACE2 and TMPRSS2 in the lung epithelium might have implications for the risk of SARS-CoV-2 infection and severity of COVID-19. We use human genetic variants that proxy angiotensin-converting enzyme (ACE) inhibitor drug effects and cardiovascular risk factors to investigate whether these exposures affect lung ACE2 and TMPRSS2 gene expression and circulating ACE2 levels. We observed no consistent evidence of an association of genetically predicted serum ACE levels with any of our outcomes. There was weak evidence for an association of genetically predicted serum ACE levels with ACE2 gene expression in the Lung eQTL Consortium (p = 0.014), but this finding did not replicate. There was evidence of a positive association of genetic liability to type 2 diabetes mellitus with lung ACE2 gene expression in the Gene-Tissue Expression (GTEx) study (p = 4 \u00d7 10-4) and with circulating plasma ACE2 levels in the INTERVAL study (p = 0.03), but not with lung ACE2 expression in the Lung eQTL Consortium study (p = 0.68). There were no associations of genetically proxied liability to the other cardiometabolic traits with any outcome. This study does not provide consistent evidence to support an effect of serum ACE levels (as a proxy for ACE inhibitors) or cardiometabolic risk factors on lung ACE2 and TMPRSS2 expression or plasma ACE2 levels.", "doi": "10.1098/rsos.200958", "pmid": "33391794", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: H2020": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-07T11:18:38.095Z", "modified": "2021-02-26T08:45:48.911Z"}, {"entity": "publication", "iuid": "d1dfa2e8f18249f6a09ed3001da4e273", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1dfa2e8f18249f6a09ed3001da4e273.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1dfa2e8f18249f6a09ed3001da4e273"}}, "title": "A roadmap to the safe practice of forensic medicine in the COVID-19 pandemic.", "authors": [{"family": "Parekh", "given": "Utsav", "initials": "U"}, {"family": "Chariot", "given": "Patrick", "initials": "P"}, {"family": "Dang", "given": "Catherine", "initials": "C"}, {"family": "Stray-Pedersen", "given": "Arne", "initials": "A"}, {"family": "Druid", "given": "Henrik", "initials": "H"}, {"family": "Sajantila", "given": "Antti", "initials": "A"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "J Forensic Leg Med", "issn": "1878-7487", "volume": "76", "issue": null, "pages": "102036", "issn-l": "1752-928X"}, "abstract": "The COVID-19 pandemic has forced forensic practitioners to consider how we perform our normal duties, especially when those duties involve humans. The potential for contracting the virus from working in close contact with living sufferers is high, and we have yet to fully determine the risk of infection from the deceased. In an attempt to support the community, the Journal of Forensic & Legal Medicine has drawn together three articles which underline the importance of continued forensic medical practice during the pandemic and highlight some factors to consider in a Roadmap towards safe practice. Our Roadmap has intentionally taken an international perspective and supports other work we have published in the Journal on our collective response to the COVID-19 crisis.", "doi": "10.1016/j.jflm.2020.102036", "pmid": "33208233", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1752-928X(20)30143-8"}, {"db": "pmc", "key": "PMC7560269"}], "notes": [], "created": "2020-11-26T12:35:58.300Z", "modified": "2020-11-27T09:50:51.155Z"}, {"entity": "publication", "iuid": "6782ff1d9e184517b9530963a13c83ba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6782ff1d9e184517b9530963a13c83ba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6782ff1d9e184517b9530963a13c83ba"}}, "title": "H-WORK Project: Multilevel Interventions to Promote Mental Health in SMEs and Public Workplaces.", "authors": [{"family": "De Angelis", "given": "Marco", "initials": "M"}, {"family": "Giusino", "given": "Davide", "initials": "D"}, {"family": "Nielsen", "given": "Karina", "initials": "K"}, {"family": "Aboagye", "given": "Emmanuel", "initials": "E"}, {"family": "Christensen", "given": "Marit", "initials": "M"}, {"family": "Innstrand", "given": "Siw Tone", "initials": "ST"}, {"family": "Mazzetti", "given": "Greta", "initials": "G"}, {"family": "van den Heuvel", "given": "Machteld", "initials": "M"}, {"family": "Sijbom", "given": "Roy B L", "initials": "RBL"}, {"family": "Pelzer", "given": "Vince", "initials": "V"}, {"family": "Chiesa", "given": "Rita", "initials": "R"}, {"family": "Pietrantoni", "given": "Luca", "initials": "L"}], "type": "journal article", "published": "2020-10-31", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "21", "pages": null}, "abstract": "The paper describes the study design, research questions and methods of a large, international intervention project aimed at improving employee mental health and well-being in SMEs and public organisations. The study is innovative in multiple ways. First, it goes beyond the current debate on whether individual- or organisational-level interventions are most effective in improving employee health and well-being and tests the cumulative effects of multilevel interventions, that is, interventions addressing individual, group, leader and organisational levels. Second, it tailors its interventions to address the aftermaths of the Covid-19 pandemic and develop suitable multilevel interventions for dealing with new ways of working. Third, it uses realist evaluation to explore and identify the working ingredients of and the conditions required for each level of intervention, and their outcomes. Finally, an economic evaluation will assess both the cost-effectiveness analysis and the affordability of the interventions from the employer perspective. The study integrates the training transfer and the organisational process evaluation literature to develop toolkits helping end-users to promote mental health and well-being in the workplace.", "doi": "10.3390/ijerph17218035", "pmid": "33142745", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph17218035"}, {"db": "pmc", "key": "PMC7662282"}], "notes": [], "created": "2020-11-27T10:14:09.269Z", "modified": "2020-12-01T14:52:50.692Z"}, {"entity": "publication", "iuid": "545c2179da7042fdaa7d12bedd3fc5b8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/545c2179da7042fdaa7d12bedd3fc5b8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/545c2179da7042fdaa7d12bedd3fc5b8"}}, "title": "The COVID-19 pandemic as disjuncture: Lifelong learning in a context of fear.", "authors": [{"family": "Bjursell", "given": "Cecilia", "initials": "C"}], "type": "journal article", "published": "2020-10-30", "journal": {"title": "Int Rev Educ", "issn": "0020-8566", "volume": null, "issue": null, "pages": "1-17", "issn-l": null}, "abstract": "The COVID-19 pandemic has caused a number of fundamental changes in different societies, and can therefore be understood as creating \"disjuncture\" in our lives. Disjuncture is a concept proposed by adult educator Peter Jarvis to describe the phenomenon of what happens when an individual is confronted with an experience that conflicts with her/his previous understanding of the world. Faced with a situation that creates disjuncture, the person is compelled to find new knowledge and new ways of doing things; i.e., he/she must embark on a learning process. The recent introduction of social distancing as a measure aiming to reduce transmission of the COVID-19 virus has dramatically changed people's behaviour, but this measure does not only have preventive and desirable effects. There is an associated risk for increased isolation among the older generations of the population, as well as a change in intergenerational relationships. Although the current pandemic (as disjuncture) may potentially initiate major learning processes in the human collective, we should remember that disjuncture is often theorised within neutral, or even positive, contexts. In a context of fear, however, learning may result in a narrowing of mindsets and a rejection of collective efforts and solidarity between generations. In terms of the types of learning triggered by the current pandemic (as disjuncture), one problem is non-reflective learning, which primarily occurs on a behavioural level. We need to recognise this and engage in reflective learning if we are to make the choices that will lead to a society that is worth living in for all generations. Our goal must be to learn to be a person in a post-pandemic society.", "doi": "10.1007/s11159-020-09863-w", "pmid": "33144741", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "9863"}, {"db": "pmc", "key": "PMC7596631"}], "notes": [], "created": "2020-12-01T14:49:36.708Z", "modified": "2020-12-01T14:49:48.354Z"}, {"entity": "publication", "iuid": "3a127f769d8a486b86f9abc60a8625b6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a127f769d8a486b86f9abc60a8625b6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a127f769d8a486b86f9abc60a8625b6"}}, "title": "Pfam: The protein families database in 2021.", "authors": [{"family": "Mistry", "given": "Jaina", "initials": "J"}, {"family": "Chuguransky", "given": "Sara", "initials": "S"}, {"family": "Williams", "given": "Lowri", "initials": "L"}, {"family": "Qureshi", "given": "Matloob", "initials": "M"}, {"family": "Salazar", "given": "Gustavo A", "initials": "GA"}, {"family": "Sonnhammer", "given": "Erik L L", "initials": "ELL"}, {"family": "Tosatto", "given": "Silvio C E", "initials": "SCE"}, {"family": "Paladin", "given": "Lisanna", "initials": "L"}, {"family": "Raj", "given": "Shriya", "initials": "S"}, {"family": "Richardson", "given": "Lorna J", "initials": "LJ"}, {"family": "Finn", "given": "Robert D", "initials": "RD"}, {"family": "Bateman", "given": "Alex", "initials": "A"}], "type": "journal article", "published": "2020-10-30", "journal": {"title": "Nucleic Acids Res", "issn": "1362-4962", "volume": null, "issue": null, "issn-l": "0305-1048"}, "abstract": "The Pfam database is a widely used resource for classifying protein sequences into families and domains. Since Pfam was last described in this journal, over 350 new families have been added in Pfam 33.1 and numerous improvements have been made to existing entries. To facilitate research on COVID-19, we have revised the Pfam entries that cover the SARS-CoV-2 proteome, and built new entries for regions that were not covered by Pfam. We have reintroduced Pfam-B which provides an automatically generated supplement to Pfam and contains 136 730 novel clusters of sequences that are not yet matched by a Pfam family. The new Pfam-B is based on a clustering by the MMseqs2 software. We have compared all of the regions in the RepeatsDB to those in Pfam and have started to use the results to build and refine Pfam repeat families. Pfam is freely available for browsing and download at http://pfam.xfam.org/.", "doi": "10.1093/nar/gkaa913", "pmid": "33125078", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "5943818"}], "notes": [], "created": "2020-12-01T15:03:52.765Z", "modified": "2020-12-01T15:03:52.776Z"}, {"entity": "publication", "iuid": "1b4f51d5b73a4d18a3eb1a4c6b7afa37", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b4f51d5b73a4d18a3eb1a4c6b7afa37.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b4f51d5b73a4d18a3eb1a4c6b7afa37"}}, "title": "Multipel skleros och covid-19 \u2013 kunskapen \u00e4nnu begr\u00e4nsad", "authors": [{"family": "Iacobaeus", "given": "Ellen", "initials": "E"}, {"family": "Burman", "given": "Joachim", "initials": "J"}, {"family": "Landtblom", "given": "Anne-Marie", "initials": "A"}], "type": "journal article", "published": "2020-10-30", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": null, "doi": null, "pmid": "33150577", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "20129"}], "notes": [], "created": "2020-11-27T10:08:24.361Z", "modified": "2020-12-08T07:13:40.676Z"}, {"entity": "publication", "iuid": "65e7ee33ba5642e49ac02b48b23e635e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65e7ee33ba5642e49ac02b48b23e635e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65e7ee33ba5642e49ac02b48b23e635e"}}, "title": "Mathematical Models for COVID-19 Pandemic: A Comparative Analysis.", "authors": [{"family": "Adiga", "given": "Aniruddha", "initials": "A"}, {"family": "Dubhashi", "given": "Devdatt", "initials": "D"}, {"family": "Lewis", "given": "Bryan", "initials": "B"}, {"family": "Marathe", "given": "Madhav", "initials": "M"}, {"family": "Venkatramanan", "given": "Srinivasan", "initials": "S"}, {"family": "Vullikanti", "given": "Anil", "initials": "A"}], "type": "journal article", "published": "2020-10-30", "journal": {"title": "J Indian Inst Sci", "issn": "0970-4140", "volume": null, "issue": null, "pages": "1-15", "issn-l": "0970-4140"}, "abstract": "COVID-19 pandemic represents an unprecedented global health crisis in the last 100 years. Its economic, social and health impact continues to grow and is likely to end up as one of the worst global disasters since the 1918 pandemic and the World Wars. Mathematical models have played an important role in the ongoing crisis; they have been used to inform public policies and have been instrumental in many of the social distancing measures that were instituted worldwide. In this article, we review some of the important mathematical models used to support the ongoing planning and response efforts. These models differ in their use, their mathematical form and their scope.", "doi": "10.1007/s41745-020-00200-6", "pmid": "33144763", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "200"}, {"db": "pmc", "key": "PMC7596173"}], "notes": [], "created": "2020-11-27T11:01:16.970Z", "modified": "2020-12-01T14:48:54.078Z"}, {"entity": "publication", "iuid": "e096c3052ebf45a78d3bb90283e18088", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e096c3052ebf45a78d3bb90283e18088.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e096c3052ebf45a78d3bb90283e18088"}}, "title": "The complex distribution of SARS-CoV-2 in a population invalidates the use of the per capita rates of death and infection in international comparisons.", "authors": [{"family": "Silva", "given": "W T A F", "initials": "WTAF"}], "type": "letter", "published": "2020-10-29", "journal": {"title": "Public Health", "issn": "1476-5616", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.puhe.2020.10.019", "pmid": "33334594", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0033-3506(20)30461-3"}, {"db": "pmc", "key": "PMC7598416"}], "notes": [], "created": "2020-12-21T08:56:24.887Z", "modified": "2021-02-26T08:47:00.242Z"}, {"entity": "publication", "iuid": "55e43348983d455fad0063218a676042", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/55e43348983d455fad0063218a676042.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/55e43348983d455fad0063218a676042"}}, "title": "Risk factors for mortality in adult COVID-19 patients; frailty predicts fatal outcome in older patients.", "authors": [{"family": "Tehrani", "given": "Sara", "initials": "S"}, {"family": "Killander", "given": "Anna", "initials": "A"}, {"family": "\u00c5strand", "given": "Per", "initials": "P"}, {"family": "Jakobsson", "given": "Jan", "initials": "J"}, {"family": "Gille-Johnson", "given": "Patrik", "initials": "P"}], "type": "journal article", "published": "2020-10-29", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": null, "issue": null, "pages": null}, "abstract": "This study investigated demographics, co-morbidities and death rate in hospitalized patients with confirmed COVID-19. In addition, we hypothesized that functional status, according to Clinical Frailty Scale (CFS), in patients aged 65 years and older is a better predictor of poor outcome than age and co-morbidities.\r\n\r\nA total of 255 randomly selected COVID-19 patients admitted at a university hospital were included and followed for 60 days. Patient data was extracted manually from the electronic health records using a standardized protocol.\r\n\r\nThe age of the study population ranged between 20 and 103 years, (mean age was 66\u00b117 years). Hypertension, diabetes mellitus and obesity were the three most prevalent co-morbidities. At the 60-day follow-up, 70 patients (27%) had died. In multivariate analyses, age, chronic kidney disease and previous stroke were associated with death. Most fatal cases (90%) occurred in older patients. Among the older patients, CFS was the only predictor of death in multivariate analyses.\r\n\r\nThis study shows that higher age, chronic kidney disease and previous stroke significantly contribute to a fatal outcome in hospitalized patients with COVID-19. In patients aged 65 years and older, CFS was the strongest prognostic factor for mortality.", "doi": "10.1016/j.ijid.2020.10.071", "pmid": "33130213", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(20)32276-1"}], "notes": [], "created": "2020-11-27T10:18:27.233Z", "modified": "2022-11-09T08:41:21.795Z"}, {"entity": "publication", "iuid": "7d0b505b0cde44238632734beb405eaa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d0b505b0cde44238632734beb405eaa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d0b505b0cde44238632734beb405eaa"}}, "title": "Emergency Healthcare Providers' Perceptions of Preparedness and Willingness to Work during Disasters and Public Health Emergencies.", "authors": [{"family": "Sultan", "given": "Mohammed Ali Salem", "initials": "MAS"}, {"family": "L\u00f8we S\u00f8rensen", "given": "Jarle", "initials": "J"}, {"family": "Carlstr\u00f6m", "given": "Eric", "initials": "E"}, {"family": "Mortelmans", "given": "Luc", "initials": "L"}, {"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}], "type": "journal article", "published": "2020-10-29", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "volume": "8", "issue": "4", "issn-l": null}, "abstract": "This study evaluates the perceptions of preparedness and willingness to work during disasters and public health emergencies among 213 healthcare workers at hospitals in the southern region of Saudi Arabia by using a quantitative survey (Fight or Flight). The results showed that participants' willingness to work unconditionally during disasters and emergencies varied based on the type of condition: natural disasters (61.97%), seasonal influenza pandemic (52.58%), smallpox pandemic (47.89%), SARS/COVID-19 pandemic (43.56%), special flu pandemic (36.15%), mass shooting (37.56%), chemical incident and bombing threats (31.92%), biological events (28.17%), Ebola outbreaks (27.7%), and nuclear incident (24.88%). A lack of confidence and the absence of safety assurance for healthcare workers and their family members were the most important reasons cited. The co-variation between age and education versus risk and danger by Spearman's rho confirmed a small negative correlation between education and danger at a 95% level of significance, meaning that educated healthcare workers have less fear to work under dangerous events. Although the causes of unsuccessful management of disasters and emergencies may vary, individuals' characteristics, such as lack of confidence and emotional distractions because of uncertainty about the safety issues, may also play a significant role. Besides educational initiatives, other measures, which guarantee the safety of healthcare providers and their family members, should be established and implemented.", "doi": "10.3390/healthcare8040442", "pmid": "33138164", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "healthcare8040442"}], "notes": [], "created": "2020-12-01T14:59:58.421Z", "modified": "2021-02-26T08:45:48.385Z"}, {"entity": "publication", "iuid": "8dad937a4d5c4d60a37ee7eb0be35ca4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8dad937a4d5c4d60a37ee7eb0be35ca4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8dad937a4d5c4d60a37ee7eb0be35ca4"}}, "title": "The digital immunization system of the future: imagining a patient-centric, interoperable immunization information system.", "authors": [{"family": "Atkinson", "given": "Katherine M", "initials": "KM"}, {"family": "Mithani", "given": "Salima Saleem", "initials": "SS"}, {"family": "Bell", "given": "Cameron", "initials": "C"}, {"family": "Rubens-Augustson", "given": "Taylor", "initials": "T"}, {"family": "Wilson", "given": "Kumanan", "initials": "K"}], "type": "journal article", "published": "2020-10-28", "journal": {"title": "Ther Adv Vaccines Immunother", "issn": "2515-1355", "volume": "8", "issue": null, "pages": "2515135520967203", "issn-l": null}, "abstract": "To ensure the effectiveness of increasingly complex immunization programs in upper-middle and high-income settings, comprehensive information systems are needed to track immunization uptake at individual and population levels. The maturity of cloud systems and mobile technologies has created new possibilities for immunization information systems. In this paper, we describe a vision for the next generation of digital immunization information systems for upper-middle and high-income settings based on our experience in Canada. These systems center on the premise that the public is engaged and informed about the immunization process beyond their interaction with primary care, and that they will be a contributor and auditor of immunization data. The digital immunization system of the future will facilitate reporting of adverse events following immunization, issue digital immunization receipts, permit identification of areas of need and allow for delivery of interventions targeting these areas. Through features like immunization reminders and targeted immunization promotion campaigns, the system will reduce many of the known barriers that influence immunization rates. In light of the global COVID-19 pandemic, adaptive digital public health information systems will be required to guide the rollout and post-market surveillance of the SARS-CoV-2 vaccine.", "doi": "10.1177/2515135520967203", "pmid": "33681700", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1177_2515135520967203"}, {"db": "pmc", "key": "PMC7900792"}], "notes": [], "created": "2021-03-09T15:36:05.453Z", "modified": "2021-03-09T15:36:05.475Z"}, {"entity": "publication", "iuid": "b15ab0bc7c204f5eb3258fdd9c3b38e3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b15ab0bc7c204f5eb3258fdd9c3b38e3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b15ab0bc7c204f5eb3258fdd9c3b38e3"}}, "title": "Similar Clinical Course and Significance of Circulating Innate and Adaptive Immune Cell Counts in STEMI and COVID-19.", "authors": [{"family": "de Dios", "given": "Elena", "initials": "E"}, {"family": "Rios-Navarro", "given": "Cesar", "initials": "C"}, {"family": "Perez-Sole", "given": "Nerea", "initials": "N"}, {"family": "Gavara", "given": "Jose", "initials": "J"}, {"family": "Marcos-Garces", "given": "Victor", "initials": "V"}, {"family": "Rodr\u00edguez", "given": "Enrique", "initials": "E"}, {"family": "Carratal\u00e1", "given": "Arturo", "initials": "A"}, {"family": "Forner", "given": "Maria J", "initials": "MJ"}, {"family": "Navarro", "given": "Jorge", "initials": "J"}, {"family": "Blasco", "given": "Maria L", "initials": "ML"}, {"family": "Bondia", "given": "Elvira", "initials": "E"}, {"family": "Signes-Costa", "given": "Jaime", "initials": "J"}, {"family": "Vila", "given": "Jose M", "initials": "JM"}, {"family": "Forteza", "given": "Maria J", "initials": "MJ"}, {"family": "Chorro", "given": "Francisco J", "initials": "FJ"}, {"family": "Bodi", "given": "Vicente", "initials": "V"}], "type": "journal article", "published": "2020-10-28", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "9", "issue": "11", "issn-l": "2077-0383"}, "abstract": "This study aimed to assess the time course of circulating neutrophil and lymphocyte counts and their ratio (NLR) in ST-segment elevation myocardial infarction (STEMI) and coronavirus disease (COVID)-19 and explore their associations with clinical events and structural damage. Circulating neutrophil, lymphocyte and NLR were sequentially measured in 659 patients admitted for STEMI and in 103 COVID-19 patients. The dynamics detected in STEMI (within a few hours) were replicated in COVID-19 (within a few days). In both entities patients with events and with severe structural damage displayed higher neutrophil and lower lymphocyte counts. In both scenarios, higher maximum neutrophil and lower minimum lymphocyte counts were associated with more events and more severe organ damage. NLR was higher in STEMI and COVID-19 patients with the worst clinical and structural outcomes. A canonical deregulation of the immune response occurs in STEMI and COVID-19 patients. Boosted circulating innate (neutrophilia) and depressed circulating adaptive immunity (lymphopenia) is associated with more events and severe organ damage. A greater understanding of these critical illnesses is pivotal to explore novel alternative therapies.", "doi": "10.3390/jcm9113484", "pmid": "33126723", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "jcm9113484"}], "notes": [], "created": "2020-11-27T10:19:02.909Z", "modified": "2021-02-26T08:45:03.195Z"}, {"entity": "publication", "iuid": "95d2453a375346cab92217de9d6b6367", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95d2453a375346cab92217de9d6b6367.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95d2453a375346cab92217de9d6b6367"}}, "title": "Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19?", "authors": [{"family": "Palit", "given": "Partha", "initials": "P"}, {"family": "Chattopadhyay", "given": "Debprasad", "initials": "D"}, {"family": "Thomas", "given": "Sabu", "initials": "S"}, {"family": "Kundu", "given": "Amit", "initials": "A"}, {"family": "Kim", "given": "Hyung Sik", "initials": "HS"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}], "type": "journal article", "published": "2020-10-28", "journal": {"title": "Phytomedicine", "issn": "1618-095X", "volume": null, "issue": null, "pages": "153396", "issn-l": "0944-7113"}, "abstract": "Currently, novel coronavirus disease (Covid-19) outbreak creates global panic across the continents, as people from almost all countries and territories have been affected by this highly contagious viral disease. The scenario is deteriorating due to lack of proper & specific target-oriented pharmacologically safe prophylactic agents or drugs, and or any effective vaccine. drug development is urgently required to back in the normalcy in the community and to combat this pandemic.\n\nThus, we have proposed two novel drug targets, Furin and TMPRSS2, as Covid-19 treatment strategy. We have highlighted this target-oriented novel drug delivery strategy, based on their pathophysiological implication on SARS-CoV-2 infection, as evident from earlier SARS-CoV-1, MERS, and influenza virus infection via host cell entry, priming, fusion, and endocytosis. STUDY DESIGN & METHODS: An earlier study suggested that Furin and TMPRSS2 knockout mice had reduced level of viral load and a lower degree of organ damage such as the lung. The present study thus highlights the promise of some selected novel and potential anti-viral Phytopharmaceutical that bind to Furin and TMPRSS2 as target.\n\nFew of them had shown promising anti-viral response in both preclinical and clinical study with acceptable therapeutic safety-index.\n\nHence, this strategy may limit life-threatening Covid-19 infection and its mortality rate through nano-suspension based intra-nasal or oral nebulizer spray, to treat mild to moderate SARS-COV-2 infection when Furin and TMPRSS2 receptor may initiate to express and activate for processing the virus to cause cellular infection by replication within the host cell and blocking of host-viral interaction.", "doi": "10.1016/j.phymed.2020.153396", "pmid": "33380375", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0944-7113(20)30227-0"}, {"db": "pmc", "key": "PMC7591300"}], "notes": [], "created": "2021-01-07T12:09:39.696Z", "modified": "2021-01-07T12:09:39.707Z"}, {"entity": "publication", "iuid": "101defb34cf1411892223412d5e22d70", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/101defb34cf1411892223412d5e22d70.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/101defb34cf1411892223412d5e22d70"}}, "title": "Impact of COVID-19-Related Lockdown on Psychosocial, Cognitive, and Functional Well-Being in Adults With Down Syndrome.", "authors": [{"family": "Villani", "given": "Emanuele Rocco", "initials": "ER"}, {"family": "Vetrano", "given": "Davide Liborio", "initials": "DL"}, {"family": "Damiano", "given": "Cecilia", "initials": "C"}, {"family": "Paola", "given": "Antonella Di", "initials": "AD"}, {"family": "Ulgiati", "given": "Aurora Maria", "initials": "AM"}, {"family": "Martin", "given": "Lynn", "initials": "L"}, {"family": "Hirdes", "given": "John P", "initials": "JP"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Bernabei", "given": "Roberto", "initials": "R"}, {"family": "Onder", "given": "Graziano", "initials": "G"}, {"family": "Carf\u00ec", "given": "Angelo", "initials": "A"}], "type": "journal article", "published": "2020-10-28", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "issn-l": "1664-0640", "volume": "11", "issue": null, "pages": "578686"}, "abstract": "People with Down Syndrome (DS) have a high prevalence of physical and psychiatric comorbidities and experience early-onset dementia. With the outbreak of CoVID-19 pandemic, strict social isolation measures have been necessary to prevent the spreading of the disease. Effects of this lockdown period on behavior, mood and cognition in people with DS have not been assessed so far. In the present clinical study, we investigated the impact of CoVID-19-related lockdown on psychosocial, cognitive and functional well-being in a sample population of 46 adults with DS. The interRAI Intellectual Disability standardized assessment instrument, which includes measures of social withdrawal, functional impairment, aggressive behavior and depressive symptoms, was used to perform a three time-point evaluation (two pre-lockdown and one post-lockdown) in 37 subjects of the study sample, and a two time point evaluation (one pre- and one post-lockdown) in 9 subjects. Two mixed linear regression models - one before and one after the lockdown - have been fitted for each scale in order to investigate the change in the time-dependent variation of the scores. In the pre-lockdown period, significant worsening over time (i.e., per year) was found for the Depression Rating Scale score (\u03b2 = 0.55; 95% CI 0.34; 0.76). In the post-lockdown period, a significant worsening in social withdrawal (\u03b2 = 3.05, 95% CI 0.39; 5.70), instrumental activities of daily living (\u03b2 = 1.13, 95% CI 0.08; 2.18) and depression rating (\u03b2 = 1.65, 95% CI 0.33; 2.97) scales scores was observed, as was a significant improvement in aggressive behavior (\u03b2 = -1.40, 95% CI -2.69; -0.10). Despite the undoubtful importance of the lockdown in order to reduce the spreading of the CoVID-19 pandemic, the related social isolation measures suggest an exacerbation of depressive symptoms and a worsening in functional status in a sample of adults with DS. At the opposite, aggressive behavior was reduced after the lockdown period. This finding could be related to the increase of negative and depressive symptoms in the study population. Studies with longer follow-up period are needed to assess persistence of these effects.", "doi": "10.3389/fpsyt.2020.578686", "pmid": "33192717", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7655916"}], "notes": [], "created": "2020-11-27T09:55:50.227Z", "modified": "2023-06-19T15:28:57.715Z"}, {"entity": "publication", "iuid": "d019e593ded147cd8a6fa483b8202a56", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d019e593ded147cd8a6fa483b8202a56.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d019e593ded147cd8a6fa483b8202a56"}}, "title": "Emergency department crowding and hospital transformation during COVID-19, a retrospective, descriptive study of a university hospital in Stockholm, Sweden.", "authors": [{"family": "Af Ugglas", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Skyttberg", "given": "Niclas", "initials": "N"}, {"family": "Wladis", "given": "Andreas", "initials": "A"}, {"family": "Dj\u00e4rv", "given": "Therese", "initials": "T"}, {"family": "Holzmann", "given": "Martin J", "initials": "MJ"}], "type": "journal article", "published": "2020-10-28", "journal": {"title": "Scand J Trauma Resusc Emerg Med", "issn": "1757-7241", "volume": "28", "issue": "1", "pages": "107", "issn-l": "1757-7241"}, "abstract": "COVID-19 presents challenges to the emergency care system that could lead to emergency department (ED) crowding. The Huddinge site at the Karolinska university hospital (KH) responded through a rapid transformation of inpatient care capacity together with changing working methods in the ED. The aim is to describe the KH response to the COVID-19 crisis, and how ED crowding, and important input, throughput and output factors for ED crowding developed at KH during a 30-day baseline period followed by the first 60 days of the COVID-19 outbreak in Stockholm Region.\n\nDifferent phases in the development of the crisis were described and identified retrospectively based on major events that changed the conditions for the ED. Results were presented for each phase separately. The outcome ED length of stay (ED LOS) was calculated with mean and 95% confidence intervals. Input, throughput, output and demographic factors were described using distributions, proportions and means. Pearson correlation between ED LOS and emergency ward occupancy by phase was estimated with 95% confidence interval.\n\nAs new working methods were introduced between phase 2 and 3, ED LOS declined from mean (95% CI) 386 (373-399) minutes to 307 (297-317). Imaging proportion was reduced from 29 to 18% and admission rate increased from 34 to 43%. Correlation (95% CI) between emergency ward occupancy and ED LOS by phase was 0.94 (0.55-0.99).\n\nIt is possible to avoid ED crowding, even during extreme and quickly changing conditions by leveraging previously known input, throughput and output factors. One key factor was the change in working methods in the ED with higher competence, less diagnostics and increased focus on rapid clinical admission decisions. Another important factor was the reduction in bed occupancy in emergency wards that enabled a timely admission to inpatient care. A key limitation was the retrospective study design.", "doi": "10.1186/s13049-020-00799-6", "pmid": "33115521", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13049-020-00799-6"}, {"db": "pmc", "key": "PMC7592192"}], "notes": [], "created": "2020-11-27T10:22:02.875Z", "modified": "2021-02-26T08:45:48.728Z"}, {"entity": "publication", "iuid": "cbf9d53589f342709917243e17cdc214", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cbf9d53589f342709917243e17cdc214.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cbf9d53589f342709917243e17cdc214"}}, "title": "Covid-19: risks to healthcare workers and their families.", "authors": [{"family": "Karlsson", "given": "Ulf", "initials": "U"}, {"family": "Fraenkel", "given": "Carl-Johan", "initials": "C"}], "type": "editorial", "published": "2020-10-28", "journal": {"title": "BMJ", "issn": "1756-1833", "issn-l": null, "volume": "371", "issue": null, "pages": "m3944"}, "abstract": "Editorial", "doi": "10.1136/bmj.m3944", "pmid": "33115772", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-01T15:11:01.785Z", "modified": "2020-12-01T15:11:37.521Z"}, {"entity": "publication", "iuid": "12fc3149e6b4409e9a1f725ef4387c4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/12fc3149e6b4409e9a1f725ef4387c4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/12fc3149e6b4409e9a1f725ef4387c4d"}}, "title": "The Impact of the COVID-19 Pandemic and Emergency Distance Teaching on the Psychological Status of University Teachers: A Cross-Sectional Study in Jordan.", "authors": [{"family": "Akour", "given": "Amal", "initials": "A"}, {"family": "Al-Tammemi", "given": "Ala'a B", "initials": "AB"}, {"family": "Barakat", "given": "Muna", "initials": "M"}, {"family": "Kanj", "given": "Rama", "initials": "R"}, {"family": "Fakhouri", "given": "Hussam N", "initials": "HN"}, {"family": "Malkawi", "given": "Ahmad", "initials": "A"}, {"family": "Musleh", "given": "Ghadeer", "initials": "G"}], "type": "journal article", "published": "2020-10-27", "journal": {"title": "Am J Trop Med Hyg", "issn": "1476-1645", "volume": null, "issue": null, "issn-l": "0002-9637"}, "abstract": "The COVID-19 pandemic has struck many countries globally. Jordan has implemented strict nationwide control measures to halt the viral spread, one of which was the closure of universities and shifting to remote teaching. The impact of this pandemic could extend beyond the risk of physical harm to substantial psychological consequences. Our study aimed at assessing 1) psychological status, 2) challenges of distance teaching, and 3) coping activities and pandemic-related concerns among university teachers in Jordan in the midst of COVID-19-related quarantine and control measures. We conducted a cross-sectional study using an anonymous online survey. The measure of psychological distress was obtained using a validated Arabic version of the Kessler Distress Scale (K10). Other information collected included sociodemographic profile, methods used to handle distress, motivation to participate in distance teaching, and challenges of distance teaching as well as the most worrisome issues during this pandemic. Three hundred eighty-two university teachers returned completed surveys. Results of K10 showed that 31.4% of respondents had severe distress and 38.2% had mild to moderate distress. Whereas gender was not associated with distress severity, age had a weak negative correlation (Rho = -0.19, P < 0.0001). Interestingly, most teachers had moderate to high motivation for distance teaching. Engagement with family was the most reported self-coping activity. More than half of the participants were most concerned and fearful about SARS-CoV-2 infection. In conclusion, university teachers have shown to exhibit various levels of psychological distress and challenges during the implementation of precautionary national measures in the battle against COVID-19 in Jordan.", "doi": "10.4269/ajtmh.20-0877", "pmid": "33124547", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-01T15:07:37.597Z", "modified": "2020-12-01T15:07:37.607Z"}, {"entity": "publication", "iuid": "83fad77501a1445eb5aea9d17c557e17", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/83fad77501a1445eb5aea9d17c557e17.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/83fad77501a1445eb5aea9d17c557e17"}}, "title": "On the relationship between BCG coverage and national Covid-19 outcome: could \"heterologous\" herd immunity explain why some countries are better off?", "authors": [{"family": "Lerm", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2020-10-27", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": "288", "issue": "6", "pages": "682-688", "issn-l": null}, "abstract": "The Covid-19 pandemic has affected most parts of the global society since its emergence and the scientific community has been challenged with challenging questions urgently demanding answers. One of the early hypotheses on Covid-19 outcome was that some protection could be offered by the tuberculosis vaccine (BCG) and several clinical studies were initiated along with the emergence of numerous observational studies on the relationship between BCG and Covid-19 severity. In the present work, I demonstrate a strong correlation between the number of years that countries implemented BCG vaccination plans and age-standardised mortality rates during the first months of the pandemic in Europe. Further analyses of age groups in two European countries with comparably few confounding factors and easily identifiable groups of BCG-vaccinated and non-vaccinated subgroups suggest a population-level effect of BCG on national outcomes of Covid-19. This phenomenon of \"heterologous herd immunity\" deserves further investigation, both in epidemiological and experimental studies.", "doi": "10.1111/joim.13198", "pmid": "33107999", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-01T15:17:52.407Z", "modified": "2021-04-28T15:30:30.449Z"}, {"entity": "publication", "iuid": "363ed9df30a74eca934bca383d9cf3b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/363ed9df30a74eca934bca383d9cf3b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/363ed9df30a74eca934bca383d9cf3b4"}}, "title": "Global impact of the COVID-19 pandemic on cytopathology practice: Results from an international survey of laboratories in 23 countries.", "authors": [{"family": "Vigliar", "given": "Elena", "initials": "E"}, {"family": "Cepurnaite", "given": "Rima", "initials": "R"}, {"family": "Alcaraz-Mateos", "given": "Eduardo", "initials": "E"}, {"family": "Ali", "given": "Syed Z", "initials": "SZ"}, {"family": "Baloch", "given": "Zubair W", "initials": "ZW"}, {"family": "Bellevicine", "given": "Claudio", "initials": "C"}, {"family": "Bongiovanni", "given": "Massimo", "initials": "M"}, {"family": "Botsun", "given": "Pavlina", "initials": "P"}, {"family": "Bruzzese", "given": "Dario", "initials": "D"}, {"family": "Bubendorf", "given": "Lukas", "initials": "L"}, {"family": "B\u00fcttner", "given": "Reinhard", "initials": "R"}, {"family": "Canberk", "given": "Sule", "initials": "S"}, {"family": "Capitanio", "given": "Arrigo", "initials": "A"}, {"family": "Casadio", "given": "Chiara", "initials": "C"}, {"family": "Cazacu", "given": "Eugeniu", "initials": "E"}, {"family": "Cochand-Priollet", "given": "Beatrix", "initials": "B"}, {"family": "D'Amuri", "given": "Alessandro", "initials": "A"}, {"family": "Eloy", "given": "Catarina", "initials": "C"}, {"family": "Engels", "given": "Marianne", "initials": "M"}, {"family": "Fadda", "given": "Guido", "initials": "G"}, {"family": "Fontanini", "given": "Gabriella", "initials": "G"}, {"family": "Fulciniti", "given": "Franco", "initials": "F"}, {"family": "Hofman", "given": "Paul", "initials": "P"}, {"family": "Iaccarino", "given": "Antonino", "initials": "A"}, {"family": "Ieni", "given": "Antonio", "initials": "A"}, {"family": "Jiang", "given": "Xiaoyin Sara", "initials": "XS"}, {"family": "Kakudo", "given": "Kennichi", "initials": "K"}, {"family": "Kern", "given": "Izidor", "initials": "I"}, {"family": "Kholova", "given": "Ivana", "initials": "I"}, {"family": "Liu", "given": "Chinhua", "initials": "C"}, {"family": "Lobo", "given": "Anandi", "initials": "A"}, {"family": "Lozano", "given": "Maria D", "initials": "MD"}, {"family": "Malapelle", "given": "Umberto", "initials": "U"}, {"family": "Maleki", "given": "Zahra", "initials": "Z"}, {"family": "Michelow", "given": "Pamela", "initials": "P"}, {"family": "Musayev", "given": "Jamal", "initials": "J"}, {"family": "\u00d6zg\u00fcn", "given": "Gonca", "initials": "G"}, {"family": "Oznur", "given": "Meltem", "initials": "M"}, {"family": "Peir\u00f3 Marqu\u00e9s", "given": "Francisca Maria", "initials": "FM"}, {"family": "Pisapia", "given": "Pasquale", "initials": "P"}, {"family": "Poller", "given": "David", "initials": "D"}, {"family": "Pyzlak", "given": "Michal", "initials": "M"}, {"family": "Robinson", "given": "Betsy", "initials": "B"}, {"family": "Rossi", "given": "Esther Diana", "initials": "ED"}, {"family": "Roy-Chowdhuri", "given": "Sinchita", "initials": "S"}, {"family": "Saieg", "given": "Mauro", "initials": "M"}, {"family": "Savic Prince", "given": "Spasenija", "initials": "S"}, {"family": "Schmitt", "given": "Fernando C", "initials": "FC"}, {"family": "Javier Segu\u00ed Iv\u00e1\u00f1ez", "given": "Francisco", "initials": "F"}, {"family": "\u0160toos-Vei\u0107", "given": "Tajana", "initials": "T"}, {"family": "Sulaieva", "given": "Oksana", "initials": "O"}, {"family": "Sweeney", "given": "Brenda J", "initials": "BJ"}, {"family": "Tuccari", "given": "Giovanni", "initials": "G"}, {"family": "van Velthuysen", "given": "Marie-Louise", "initials": "ML"}, {"family": "VanderLaan", "given": "Paul A", "initials": "PA"}, {"family": "Vielh", "given": "Philippe", "initials": "P"}, {"family": "Viola", "given": "Patrizia", "initials": "P"}, {"family": "Voorham", "given": "Rinus", "initials": "R"}, {"family": "Weynand", "given": "Birgit", "initials": "B"}, {"family": "Zeppa", "given": "Pio", "initials": "P"}, {"family": "Faquin", "given": "William C", "initials": "WC"}, {"family": "Pitman", "given": "Martha Bishop", "initials": "MB"}, {"family": "Troncone", "given": "Giancarlo", "initials": "G"}], "type": "journal article", "published": "2020-10-27", "journal": {"title": "Cancer Cytopathol", "issn": "1934-6638", "volume": null, "issue": null, "issn-l": null}, "abstract": "To the authors' knowledge, the impact of the coronavirus disease 2019 (COVID-19) pandemic on cytopathology practices worldwide has not been investigated formally. In the current study, data from 41 respondents from 23 countries were reported.\n\nData regarding the activity of each cytopathology laboratory during 4 weeks of COVID-19 lockdown were collected and compared with those obtained during the corresponding period in 2019. The overall number and percentage of exfoliative and fine-needle aspiration cytology samples from each anatomic site were recorded. Differences in the malignancy and suspicious rates between the 2 periods were analyzed using a meta-analytical approach.\n\nOverall, the sample volume was lower compared with 2019 (104,319 samples vs 190,225 samples), with an average volume reduction of 45.3% (range, 0.1%-98.0%). The percentage of samples from the cervicovaginal tract, thyroid, and anorectal region was significantly reduced (P < .05). Conversely, the percentage of samples from the urinary tract, serous cavities, breast, lymph nodes, respiratory tract, salivary glands, central nervous system, gastrointestinal tract, pancreas, liver, and biliary tract increased (P < .05). An overall increase of 5.56% (95% CI, 3.77%-7.35%) in the malignancy rate in nongynecological samples during the COVID-19 pandemic was observed. When the suspicious category was included, the overall increase was 6.95% (95% CI, 4.63%-9.27%).\n\nThe COVID-19 pandemic resulted in a drastic reduction in the total number of cytology specimens regardless of anatomic site or specimen type. The rate of malignancy increased, reflecting the prioritization of patients with cancer who were considered to be at high risk. Prospective monitoring of the effect of delays in access to health services during the lockdown period is warranted.", "doi": "10.1002/cncy.22373", "pmid": "33108683", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-01T15:16:41.610Z", "modified": "2020-12-01T15:16:41.634Z"}, {"entity": "publication", "iuid": "0a1734ad80324354b397d4c7f8f4ca2f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a1734ad80324354b397d4c7f8f4ca2f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a1734ad80324354b397d4c7f8f4ca2f"}}, "title": "Frailty and comorbidity in predicting community COVID-19 mortality in the UK Biobank: the effect of sampling", "authors": [{"family": "Mak", "given": "Jonathan K L", "initials": "JKL"}, {"family": "Kuja-Halkola", "given": "Ralf", "initials": "R"}, {"family": "Wang", "given": "Yunzhang", "initials": "Y"}, {"family": "H\u00e4gg", "given": "Sara", "initials": "S"}, {"family": "Jylh\u00e4v\u00e4", "given": "Juulia", "initials": "J"}], "type": "posted-content", "published": "2020-10-27", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.10.22.20217489", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-09T19:30:28.062Z", "modified": "2021-06-09T19:30:46.038Z"}, {"entity": "publication", "iuid": "d780ed20b16b4f81a2bc925a264c0ab8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d780ed20b16b4f81a2bc925a264c0ab8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d780ed20b16b4f81a2bc925a264c0ab8"}}, "title": "Dashboard of Sentiment in Austrian Social Media During COVID-19.", "authors": [{"family": "Pellert", "given": "Max", "initials": "M"}, {"family": "Lasser", "given": "Jana", "initials": "J"}, {"family": "Metzler", "given": "Hannah", "initials": "H"}, {"family": "Garcia", "given": "David", "initials": "D"}], "type": "journal article", "published": "2020-10-26", "journal": {"title": "Front Big Data", "issn": "2624-909X", "volume": "3", "issue": null, "pages": "32", "issn-l": null}, "abstract": "To track online emotional expressions on social media platforms close to real-time during the COVID-19 pandemic, we built a self-updating monitor of emotion dynamics using digital traces from three different data sources in Austria. This allows decision makers and the interested public to assess dynamics of sentiment online during the pandemic. We used web scraping and API access to retrieve data from the news platform derstandard.at, Twitter, and a chat platform for students. We documented the technical details of our workflow to provide materials for other researchers interested in building a similar tool for different contexts. Automated text analysis allowed us to highlight changes of language use during COVID-19 in comparison to a neutral baseline. We used special word clouds to visualize that overall difference. Longitudinally, our time series showed spikes in anxiety that can be linked to several events and media reporting. Additionally, we found a marked decrease in anger. The changes lasted for remarkably long periods of time (up to 12 weeks). We have also discussed these and more patterns and connect them to the emergence of collective emotions. The interactive dashboard showcasing our data is available online at http://www.mpellert.at/covid19_monitor_austria/. Our work is part of a web archive of resources on COVID-19 collected by the Austrian National Library.", "doi": "10.3389/fdata.2020.00032", "pmid": "33693405", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7931924"}, {"db": "URL", "key": "http://www.mpellert.at/covid19_monitor_austria/.", "description": "http://www.mpellert.at/covid19_monitor_austria/."}], "notes": [], "created": "2021-03-12T06:36:40.432Z", "modified": "2021-03-12T06:37:17.326Z"}, {"entity": "publication", "iuid": "7098ed40379b4bd092504e310993f52d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7098ed40379b4bd092504e310993f52d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7098ed40379b4bd092504e310993f52d"}}, "title": "Therapist-Supported Online Interventions for Children and Young People With Tic Disorders: Lessons Learned From a Randomized Controlled Trial and Considerations for Future Practice.", "authors": [{"family": "Chamberlain", "given": "Liam R", "initials": "LR"}, {"family": "Hall", "given": "Charlotte L", "initials": "CL"}, {"family": "Andr\u00e9n", "given": "Per", "initials": "P"}, {"family": "Davies", "given": "E Bethan", "initials": "EB"}, {"family": "Kilgariff", "given": "Joseph", "initials": "J"}, {"family": "Kouzoupi", "given": "Natalia", "initials": "N"}, {"family": "Murphy", "given": "Tara", "initials": "T"}, {"family": "Hollis", "given": "Chris", "initials": "C"}], "type": "journal article", "published": "2020-10-23", "journal": {"title": "JMIR Ment Health", "issn": "2368-7959", "issn-l": null, "volume": "7", "issue": "10", "pages": "e19600"}, "abstract": "In recent years, research into internet-based cognitive behavioral therapy (iCBT) has suggested that therapist-guided digital interventions have greater engagement, adherence, and effectiveness than self-directed digital therapies. While research has focused on the effectiveness of, and adherence to, these interventions, less attention has been paid to their implementation in practice and what aspects of the therapist role support success. An understanding of the key factors related to the therapist role and intervention delivery is required if these iCBTs are to be applied in routine clinical care and outcomes optimized. In light of the coronavirus disease 2019 (COVID-19) pandemic, there is greater emphasis on allowing patients access to remote therapies. We report the experiences and reflections of 4 therapists and their 2 supervisors in delivering an online, therapist-supported intervention in a randomized controlled trial for children and young people with tic disorders (the Online Remote Behavioural Intervention for Tics [ORBIT] trial). Themes discussed include the importance of training, supervision, creating support documents/manuals, and record keeping. Alongside this are communication strategies used by therapists to encourage patient adherence and treatment effectiveness. These include rapport building, treatment personalization, and suggestions for overcoming non-engagement. These reflections offer important considerations for the delivery of iCBTs as well as implications associated with the implementation of these interventions in existing services and future research studies. We share thoughts on where iCBTs may sit in a stepped care model, how services may deal with comorbid conditions, and the potential role of iCBTs in collecting clinical data.", "doi": "10.2196/19600", "pmid": "33095180", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "v7i10e19600"}, {"db": "pmc", "key": "PMC7647804"}], "notes": [], "created": "2020-12-01T15:35:12.013Z", "modified": "2022-11-09T08:42:39.936Z"}, {"entity": "publication", "iuid": "937cc4cd55c042fcb79e0924979ed1e9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/937cc4cd55c042fcb79e0924979ed1e9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/937cc4cd55c042fcb79e0924979ed1e9"}}, "title": "The impact of delirium on outcomes for older adults hospitalised with COVID-19.", "authors": [{"family": "Marengoni", "given": "Alessandra", "initials": "A"}, {"family": "Zucchelli", "given": "Alberto", "initials": "A"}, {"family": "Grande", "given": "Giulia", "initials": "G"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Rizzuto", "given": "Debora", "initials": "D"}], "type": "journal article", "published": "2020-10-23", "journal": {"title": "Age Ageing", "issn": "1468-2834", "volume": "49", "issue": "6", "pages": "923-926", "issn-l": null}, "abstract": "Delirium is a frequent condition in hospitalized older patients and it usually has a negative prognostic value. A direct effect of SARS-COV-2 on the central nervous system (CNS) has been hypothesized.\n\nTo evaluate the presence of delirium in older patients admitted for a suspected diagnosis of COVID-19 and its impact on in-hospital mortality.\n\n91 patients, aged 70-years and older, admitted to an acute geriatric ward in Northern Italy from March 8th to April 17th, 2020.\n\nCOVID-19 cases were confirmed by reverse transcriptase-polymerase chain reaction assay for SARS-Cov-2 RNA from nasal and pharyngeal swabs. Delirium was diagnosed by two geriatricians according to the Diagnostic and Statistical Manual of Mental Disorders V (DMS V) criteria. The number of chronic diseases was calculated among a pre-defined list of 60. The pre-disease Clinical Frailty Scale (CFS) was assessed at hospital admission.\n\nOf the total sample, 39 patients died, 49 were discharged and 3 were transferred to ICU. Twenty-five patients (27.5%) had delirium. Seventy-two percent of patients with delirium died during hospitalization compared to 31.8% of those without delirium. In a multivariate logistic regression model adjusted for potential confounders, patients with delirium were four times more likely to die during hospital stay compared to those without delirium (OR = 3.98;95%CI = 1.05-17.28; p = 0.047).\n\nDelirium is common in older patients with COVID-19 and strongly associated with in-hospital mortality. Regardless of causation, either due to a direct effect of SARS-COV-2 on the CNS or to a multifactorial cause, delirium should be interpreted as an alarming prognostic indicator in older people.", "doi": "10.1093/ageing/afaa189", "pmid": "32821901", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "5894896"}, {"db": "pmc", "key": "PMC7499475"}], "notes": [], "created": "2020-12-04T08:48:39.233Z", "modified": "2021-02-26T08:45:48.468Z"}, {"entity": "publication", "iuid": "c3138d805cb14e17abf439d2118cffb6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3138d805cb14e17abf439d2118cffb6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3138d805cb14e17abf439d2118cffb6"}}, "title": "The COVID-19 pandemic in Norway and Sweden - threats, trust, and impact on daily life: a comparative survey.", "authors": [{"family": "Helsingen", "given": "Lise M", "initials": "LM"}, {"family": "Refsum", "given": "Erle", "initials": "E"}, {"family": "Gj\u00f8stein", "given": "Dagrun Kyte", "initials": "DK"}, {"family": "L\u00f8berg", "given": "Magnus", "initials": "M"}, {"family": "Bretthauer", "given": "Michael", "initials": "M"}, {"family": "Kalager", "given": "Mette", "initials": "M"}, {"family": "Emilsson", "given": "Louise", "initials": "L"}, {"family": "Clinical Effectiveness Research group", "given": "", "initials": ""}], "type": "comparative study", "published": "2020-10-23", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "20", "issue": "1", "pages": "1597"}, "abstract": "Norway and Sweden have similar populations and health care systems, but different reactions to the COVID-19 pandemic. Norway closed educational institutions, and banned sports and cultural activities; Sweden kept most institutions and training facilities open. We aimed to compare peoples' attitudes towards authorities and control measures, and perceived impact of the pandemic and implemented control measures on life in Norway and Sweden.\r\n\r\nAnonymous web-based surveys for individuals age 15 or older distributed through Facebook using the snowball method, in Norway and Sweden from mid-March to mid-April, 2020. The survey contained questions about perceived threat of the pandemic, views on infection control measures, and impact on daily life. We performed descriptive analyses of the responses and compared the two countries.\r\n\r\n3508 individuals participated in the survey (Norway 3000; Sweden 508). 79% were women, the majority were 30-49 years (Norway 60%; Sweden 47%), and about 45% of the participants in both countries had more than 4 years of higher education. Participants had high trust in the health services, but differed in the degree of trust in their government (High trust in Norway 17%; Sweden 37%). More Norwegians than Swedes agreed that school closure was a good measure (Norway 66%; Sweden 18%), that countries with open schools were irresponsible (Norway 65%; Sweden 23%), and that the threat from repercussions of the mitigation measures were large or very large (Norway 71%; Sweden 56%). Both countries had a high compliance with infection preventive measures (> 98%). Many lived a more sedentary life (Norway 69%; Sweden 50%) and ate more (Norway 44%; Sweden 33%) during the pandemic.\r\n\r\nSweden had more trust in the authorities, while Norwegians reported a more negative lifestyle during the pandemic. The level of trust in the health care system and self-reported compliance with preventive measures was high in both countries despite the differences in infection control measures.", "doi": "10.1186/s12889-020-09615-3", "pmid": "33097011", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-020-09615-3"}, {"db": "pmc", "key": "PMC7582026"}], "notes": [], "created": "2020-12-01T15:32:31.149Z", "modified": "2022-11-09T08:44:07.033Z"}, {"entity": "publication", "iuid": "82872c1166474c5fa580ddabf22ed3a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82872c1166474c5fa580ddabf22ed3a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82872c1166474c5fa580ddabf22ed3a6"}}, "title": "Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.", "authors": [{"family": "Zhang", "given": "Qian", "initials": "Q", "orcid": 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"researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4db8bd76f8844446b384a40bcf3ecc74.json"}}, {"family": "Lifton", "given": "Richard P", "initials": "RP"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Gorochov", "given": "Guy", "initials": "G"}, {"family": "B\u00e9ziat", "given": "Vivien", "initials": "V", "orcid": "0000-0002-4020-824X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ec4013e8c1f41d3b3590231e846cfc6.json"}}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E", "orcid": "0000-0002-7358-9157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c50d261245743539a5813daffcaab72.json"}}, {"family": "Sancho-Shimizu", "given": "Vanessa", "initials": "V", "orcid": "0000-0002-3519-0727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9f496e84c0b40d7a38fb4385005ad19.json"}}, {"family": "Rice", "given": "Charles M", "initials": "CM"}, {"family": "Abel", "given": "Laurent", "initials": "L", "orcid": "0000-0001-7016-6493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fd6c4593c8c492a8dad8e49cb7a832a.json"}}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD", "orcid": "0000-0002-8335-0262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3f0c0bf3c294622a95b062a5db4386d.json"}}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5369fe152ac94b5a81d4f913d85940a7.json"}}, {"family": "Su", "given": "Helen C", "initials": "HC", "orcid": "0000-0002-5582-9110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad550813f03540d9a8240a3d96ad0829.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL", "orcid": "0000-0002-7782-4169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1aca66ab7c39465faf2de03fa8a6722f.json"}}], "type": "journal article", "published": "2020-10-23", "journal": {"title": "Science", "issn": "1095-9203", "issn-l": "0036-8075", "volume": "370", "issue": "6515", "pages": "eabd4570"}, "abstract": "Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern Toll-like receptor 3 (TLR3)- and interferon regulatory factor 7 (IRF7)-dependent type I interferon (IFN) immunity to influenza virus in 659 patients with life-threatening COVID-19 pneumonia relative to 534 subjects with asymptomatic or benign infection. By testing these and other rare variants at these 13 loci, we experimentally defined LOF variants underlying autosomal-recessive or autosomal-dominant deficiencies in 23 patients (3.5%) 17 to 77 years of age. We show that human fibroblasts with mutations affecting this circuit are vulnerable to SARS-CoV-2. Inborn errors of TLR3- and IRF7-dependent type I IFN immunity can underlie life-threatening COVID-19 pneumonia in patients with no prior severe infection.", "doi": "10.1126/science.abd4570", "pmid": "32972995", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "mid", "key": "NIHMS1668514"}, {"db": "pmc", "key": "PMC7857407"}, {"db": "pii", "key": "science.abd4570"}, {"db": "Dryad", "key": "10.5061/dryad.8pk0p2nkk"}], "notes": [], "created": "2020-11-11T07:23:46.873Z", "modified": "2023-06-19T15:36:55.110Z"}, {"entity": "publication", "iuid": "1564e27d38eb434197f567c9358d5f37", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1564e27d38eb434197f567c9358d5f37.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1564e27d38eb434197f567c9358d5f37"}}, "title": "How to ventilate obese patients in the ICU.", "authors": [{"family": "De Jong", "given": "Audrey", "initials": "A"}, {"family": "Wrigge", "given": "Hermann", "initials": "H"}, {"family": "Hedenstierna", "given": "Goran", "initials": "G"}, {"family": "Gattinoni", "given": "Luciano", "initials": "L"}, {"family": "Chiumello", "given": "Davide", "initials": "D"}, {"family": "Frat", "given": "Jean-Pierre", "initials": "JP"}, {"family": "Ball", "given": "Lorenzo", "initials": "L"}, {"family": "Schetz", "given": "Miet", "initials": "M"}, {"family": "Pickkers", "given": "Peter", "initials": "P"}, {"family": "Jaber", "given": "Samir", "initials": "S"}], "type": "journal article", "published": "2020-10-23", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "volume": "46", "issue": "12", "pages": "2423-2435", "issn-l": "0342-4642"}, "abstract": "Obesity is an important risk factor for major complications, morbidity and mortality related to intubation procedures and ventilation in the intensive care unit (ICU). The fall in functional residual capacity promotes airway closure and atelectasis formation. This narrative review presents the impact of obesity on the respiratory system and the key points to optimize airway management, noninvasive and invasive mechanical ventilation in ICU patients with obesity. Non-invasive strategies should first optimize body position with reverse Trendelenburg position or sitting position. Noninvasive ventilation (NIV) is considered as the first-line therapy in patients with obesity having a postoperative acute respiratory failure. Positive pressure pre-oxygenation before the intubation procedure is the method of reference. The use of videolaryngoscopy has to be considered by adequately trained intensivists, especially in patients with several risk factors. Regarding mechanical ventilation in patients with and without acute respiratory distress syndrome (ARDS), low tidal volume (6 ml/kg of predicted body weight) and moderate to high positive end-expiratory pressure (PEEP), with careful recruitment maneuver in selected patients, are advised. Prone positioning is a therapeutic choice in severe ARDS patients with obesity. Prophylactic NIV should be considered after extubation to prevent re-intubation. If obesity increases mortality and risk of ICU admission in the overall population, the impact of obesity on ICU mortality is less clear and several confounding factors have to be taken into account regarding the \"obesity ICU paradox\".", "doi": "10.1007/s00134-020-06286-x", "pmid": "33095284", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-020-06286-x"}, {"db": "pmc", "key": "PMC7582031"}], "notes": [], "created": "2020-11-27T11:47:55.408Z", "modified": "2020-12-01T15:34:43.643Z"}, {"entity": "publication", "iuid": "f321360c50fe488b82ebe569db5f796d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f321360c50fe488b82ebe569db5f796d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f321360c50fe488b82ebe569db5f796d"}}, "title": "Autoantibodies against type I IFNs in patients with life-threatening COVID-19.", "authors": [{"family": "Bastard", "given": "Paul", "initials": "P", "orcid": 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{"family": "Zhang", "given": "Yu", "initials": "Y"}, {"family": "Dorgham", "given": "Karim", "initials": "K", "orcid": "0000-0001-9539-3203", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/343687bcbc014c7880ce47bfc772c00c.json"}}, {"family": "Philippot", "given": "Quentin", "initials": "Q"}, {"family": "Rosain", "given": "J\u00e9r\u00e9mie", "initials": "J"}, {"family": "B\u00e9ziat", "given": "Vivien", "initials": "V", "orcid": "0000-0002-4020-824X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ec4013e8c1f41d3b3590231e846cfc6.json"}}, {"family": "Manry", "given": "J\u00e9r\u00e9my", "initials": "J", "orcid": "0000-0001-5998-2051", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba0f830e329042efa24e0bb5bb8dd752.json"}}, {"family": "Shaw", "given": "Elana", "initials": "E", "orcid": "0000-0001-9265-8026", "researcher": {"href": 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"initials": "D", "orcid": "0000-0002-4571-044X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/472ec24aef0a4a81bd7f3372c21c5b01.json"}}, {"family": "Roussel", "given": "Lucie", "initials": "L", "orcid": "0000-0001-5355-702X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7edbf1a2fe08414d9259e6dd3adcd24e.json"}}, {"family": "Vinh", "given": "Donald C", "initials": "DC", "orcid": "0000-0003-1347-7767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d08bd304d9d43d980914472fa294316.json"}}, {"family": "Tangye", "given": "Stuart G", "initials": "SG", "orcid": "0000-0002-5360-5180", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58d0bf707fc24c139e36ac3d79ced381.json"}}, {"family": "Haerynck", "given": "Filomeen", "initials": "F"}, {"family": "Dalmau", "given": "David", "initials": "D", "orcid": "0000-0003-1936-478X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b04eafe2908b4f758dc3756c852bb794.json"}}, {"family": "Martinez-Picado", "given": "Javier", "initials": "J", "orcid": "0000-0002-4916-2129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d7db939b60d47999925369948f30e2b.json"}}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}, {"family": "Nussenzweig", "given": "Michel C", "initials": "MC", "orcid": "0000-0003-0592-8564", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e61ea4596aea42f290126607bd74c2b9.json"}}, {"family": "Boisson-Dupuis", "given": "St\u00e9phanie", "initials": "S", "orcid": "0000-0002-7115-116X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92c785f151bb490aa85764eb62c0508e.json"}}, {"family": "Rodr\u00edguez-Gallego", "given": "Carlos", "initials": "C", "orcid": "0000-0002-4344-8644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6c66da3a09c42d7925056c90bddedee.json"}}, {"family": "Vogt", "given": "Guillaume", "initials": "G"}, {"family": "Mogensen", "given": "Trine H", "initials": "TH", "orcid": "0000-0002-1853-9704", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/afec82740890482f8b617acee51d2401.json"}}, {"family": "Oler", "given": "Andrew J", "initials": "AJ", "orcid": "0000-0002-6310-0434", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/339a50f3711e47cb97f705498dc4e9da.json"}}, {"family": "Gu", "given": "Jingwen", "initials": "J"}, {"family": "Burbelo", "given": "Peter D", "initials": "PD", "orcid": "0000-0003-1717-048X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/caf17d6e254746ea8dc72213bcc6f65a.json"}}, {"family": "Cohen", "given": "Jeffrey I", "initials": "JI", "orcid": "0000-0003-0238-7176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f4b3e2ddf0dd40aca09dcdcb2cc7254f.json"}}, {"family": "Biondi", "given": "Andrea", "initials": "A"}, {"family": "Bettini", "given": "Laura Rachele", "initials": "LR", "orcid": "0000-0002-0280-1704", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b40303f53284f60bf2ec5b774831ae6.json"}}, {"family": "D'Angio", "given": "Mariella", "initials": "M"}, {"family": "Bonfanti", "given": "Paolo", "initials": "P", "orcid": "0000-0001-7289-8823", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52b16f4f4f5c4031a8435f6f17e791c7.json"}}, {"family": "Rossignol", "given": "Patrick", "initials": "P"}, {"family": "Mayaux", "given": "Julien", "initials": "J"}, {"family": "Rieux-Laucat", "given": "Fr\u00e9d\u00e9ric", "initials": "F", "orcid": "0000-0001-7858-7866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25490c3f0b9b4c299c3d6ae9e52faffb.json"}}, {"family": "Husebye", "given": "Eystein S", "initials": "ES", "orcid": "0000-0002-7886-2976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a6afa5e34f74d3db1aa66a6afef9724.json"}}, {"family": "Fusco", "given": "Francesca", "initials": "F"}, {"family": "Ursini", "given": "Matilde Valeria", "initials": "MV"}, {"family": "Imberti", "given": "Luisa", "initials": "L"}, {"family": "Sottini", "given": "Alessandra", "initials": "A"}, {"family": "Paghera", "given": "Simone", "initials": "S"}, {"family": "Quiros-Roldan", "given": "Eugenia", "initials": "E"}, {"family": "Rossi", "given": "Camillo", "initials": "C"}, {"family": "Castagnoli", "given": "Riccardo", "initials": "R", "orcid": "0000-0003-0029-9383", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc5b8149bfc34cc99d00f67c27b0d31f.json"}}, {"family": "Montagna", "given": "Daniela", "initials": "D"}, {"family": "Licari", "given": "Amelia", "initials": "A", "orcid": "0000-0002-1773-6482", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a39e2bbc5714bd78cc6e9116a18143b.json"}}, {"family": "Marseglia", "given": "Gian Luigi", "initials": "GL"}, {"family": "Duval", "given": "Xavier", "initials": "X"}, {"family": "Ghosn", "given": "Jade", "initials": "J"}, {"family": "HGID Lab", "given": "", "initials": ""}, {"family": "NIAID-USUHS Immune Response to COVID Group", "given": "", "initials": ""}, {"family": "COVID Clinicians", "given": "", "initials": ""}, {"family": "COVID-STORM Clinicians", "given": "", "initials": ""}, {"family": "Imagine COVID Group", "given": "", "initials": ""}, {"family": "French COVID Cohort Study Group", "given": "", "initials": ""}, {"family": "Milieu Int\u00e9rieur Consortium", "given": "", "initials": ""}, {"family": "CoV-Contact Cohort", "given": "", "initials": ""}, {"family": "Amsterdam UMC Covid-19 Biobank", "given": "", "initials": ""}, {"family": "COVID Human Genetic Effort", "given": "", "initials": ""}, {"family": "Tsang", "given": "John S", "initials": "JS", "orcid": "0000-0003-3186-3047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c9f3d88b94c4754b5fa887e3f29553b.json"}}, {"family": "Goldbach-Mansky", "given": "Raphaela", "initials": "R", "orcid": "0000-0001-7865-5769", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35abe088a9fa478c9bf9c2e1f18a3e1d.json"}}, {"family": "Kisand", "given": "Kai", "initials": "K", "orcid": "0000-0002-5426-4648", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45ab722bd98b4f23a99c3f07f0ecfa2c.json"}}, {"family": "Lionakis", "given": "Michail S", "initials": "MS"}, {"family": "Puel", "given": "Anne", "initials": "A", "orcid": "0000-0003-2603-0323", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2bdac14a1d14b8496ffd12dac6df3e5.json"}}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Holland", "given": "Steven M", "initials": "SM", "orcid": "0000-0003-3207-5464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12c5a29018ef487eb1e09ca7bba4cae6.json"}}, {"family": "Gorochov", "given": "Guy", "initials": "G"}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E", "orcid": "0000-0002-7358-9157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c50d261245743539a5813daffcaab72.json"}}, {"family": "Rice", "given": "Charles M", "initials": "CM"}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5369fe152ac94b5a81d4f913d85940a7.json"}}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD", "orcid": "0000-0002-8335-0262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3f0c0bf3c294622a95b062a5db4386d.json"}}, {"family": "Abel", "given": "Laurent", "initials": "L", "orcid": "0000-0001-7016-6493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fd6c4593c8c492a8dad8e49cb7a832a.json"}}, {"family": "Su", "given": "Helen C", "initials": "HC", "orcid": "0000-0002-5582-9110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad550813f03540d9a8240a3d96ad0829.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL", "orcid": "0000-0002-7782-4169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1aca66ab7c39465faf2de03fa8a6722f.json"}}], "type": "journal article", "published": "2020-10-23", "journal": {"title": "Science", "issn": "1095-9203", "issn-l": "0036-8075", "volume": "370", "issue": "6515", "pages": null}, "abstract": "Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-\u03c9 (IFN-\u03c9) (13 patients), against the 13 types of IFN-\u03b1 (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.", "doi": "10.1126/science.abd4585", "pmid": "32972996", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "mid", "key": "NIHMS1668509"}, {"db": "pmc", "key": "PMC7857397"}, {"db": "pii", "key": "science.abd4585"}], "notes": [], "created": "2020-10-28T08:38:59.426Z", "modified": "2023-06-19T15:37:11.302Z"}, {"entity": "publication", "iuid": "960e677d9dea43468a52138dcc29ff17", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/960e677d9dea43468a52138dcc29ff17.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/960e677d9dea43468a52138dcc29ff17"}}, "title": "Abortion regulation in Europe in the era of COVID-19: a spectrum of policy responses.", "authors": [{"family": "Moreau", "given": "Caroline", "initials": "C"}, {"family": "Shankar", "given": "Mridula", "initials": "M"}, {"family": "Glasier", "given": "Anna", "initials": "A"}, {"family": "Cameron", "given": "Sharon", "initials": "S"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}], "type": "journal article", "published": "2020-10-22", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-2009", "volume": null, "issue": null, "issn-l": "2515-1991"}, "abstract": "Unprecedented public health actions restricting movement and non-COVID related health services are likely to have affected abortion care during the pandemic in Europe. In the absence of a common approach to ensure access to this essential health service, we sought to describe the variability of abortion policies during the outbreak in Europe in order to identify strategies that improve availability and access to abortion in times of public health crises.\n\nWe collected information from 46 countries/regions: 31 for which country-experts completed a survey and 15 for which we conducted a desk review. We describe abortion regulations and changes to regulations and practice during the pandemic.\n\nDuring COVID-19, abortions were banned in six countries and suspended in one. Surgical abortion was less available due to COVID-19 in 12 countries/regions and services were not available or delayed for women with COVID-19 symptoms in eleven. No country expanded its gestational limit for abortion. Changes during COVID-19, mostly designed to reduce in-person consultations, occurred in 13 countries/regions. Altogether eight countries/regions provided home medical abortion with mifepristone and misoprostol beyond 9 weeks (from 9 weeks+6 days to 11 weeks+6 days) and 13 countries/regions up to 9 weeks (in some instances only misoprostol could be taken at home). Only six countries/regions offered abortion by telemedicine.\n\nThe lack of a unified policy response to COVID-19 restrictions has widened inequities in abortion access in Europe, but some innovations including telemedicine deployed during the outbreak could serve as a catalyst to ensure continuity and equity of abortion care.", "doi": "10.1136/bmjsrh-2020-200724", "pmid": "33093040", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjsrh-2020-200724"}], "notes": [], "created": "2020-11-26T12:30:40.338Z", "modified": "2020-12-01T15:37:55.328Z"}, {"entity": "publication", "iuid": "ff7d25c1af0a44379275ecec7e145449", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff7d25c1af0a44379275ecec7e145449.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff7d25c1af0a44379275ecec7e145449"}}, "title": "Serum-IgG responses to SARS-CoV-2 after mild and severe COVID-19 infection and analysis of IgG non-responders.", "authors": [{"family": "Marklund", "given": "Emelie", "initials": "E"}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Axelsson", "given": "Hannes", "initials": "H"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Norder", "given": "Hel\u00e9ne", "initials": "H"}, {"family": "Bemark", "given": "Mats", "initials": "M"}, {"family": "Angeletti", "given": "Davide", "initials": "D"}, {"family": "Lundgren", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Andersson", "given": "Lars Magnus", "initials": "LM"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Liljeqvist", "given": "Jan \u00c5ke", "initials": "J\u00c5"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2020-10-21", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "15", "issue": "10", "pages": "e0241104"}, "abstract": "To accurately interpret COVID-19 seroprevalence surveys, knowledge of serum-IgG responses to SARS-CoV-2 with a better understanding of patients who do not seroconvert, is imperative. This study aimed to describe serum-IgG responses to SARS-CoV-2 in a cohort of patients with both severe and mild COVID-19, including extended studies of patients who remained seronegative more than 90 days post symptom onset.\r\n\r\nSARS-CoV-2-specific IgG antibody levels were quantified using two clinically validated and widely used commercial serological assays (Architect, Abbott Laboratories and iFlash 1800, YHLO), detecting antibodies against the spike and nucleocapsid proteins.\r\n\r\nForty-seven patients (mean age 49 years, 38% female) were included. All (15/15) patients with severe symptoms and 29/32 (90.6%) patients with mild symptoms of COVID-19 developed SARS-CoV-2-specific IgG antibodies in serum. Time to seroconversion was significantly shorter (median 11 vs. 22 days, P = 0.04) in patients with severe compared to mild symptoms. Of the three patients without detectable IgG-responses after >90 days, all had detectable virus-neutralizing antibodies and in two, spike-protein receptor binding domain-specific IgG was detected with an in-house assay. Antibody titers were preserved during follow-up and all patients who seroconverted, irrespective of the severity of symptoms, still had detectable IgG levels >75 days post symptom onset.\r\n\r\nPatients with severe COVID-19 both seroconvert earlier and develop higher concentrations of SARS-CoV-2-specific IgG than patients with mild symptoms. Of those patients who not develop detectable IgG antibodies, all have detectable virus-neutralizing antibodies, suggesting immunity. Our results showing that not all COVID-19 patients develop detectable IgG using two validated commercial clinical methods, even over time, are vital for the interpretation of COVID-19 seroprevalence surveys.", "doi": "10.1371/journal.pone.0241104", "pmid": "33085715", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Research Area: Drug discovery and repurposing of drugs": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Biomarkers and systems immunology": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.5281/zenodo.3934336", "description": "https://doi.org/10.5281/zenodo.3934336"}], "notes": [], "created": "2020-10-30T11:44:05.878Z", "modified": "2022-02-14T07:47:22.475Z"}, {"entity": "publication", "iuid": "bfa69afc506849d699357613bce49a49", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bfa69afc506849d699357613bce49a49.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bfa69afc506849d699357613bce49a49"}}, "title": "Digital contact tracing and exposure notification: ethical guidance for trustworthy pandemic management.", "authors": [{"family": "Ranisch", "given": "Robert", "initials": "R"}, {"family": "Nijsingh", "given": "Niels", "initials": "N"}, {"family": "Ballantyne", "given": "Angela", "initials": "A"}, {"family": "van Bergen", "given": "Anne", "initials": "A"}, {"family": "Buyx", "given": "Alena", "initials": "A"}, {"family": "Friedrich", "given": "Orsolya", "initials": "O"}, {"family": "Hendl", "given": "Tereza", "initials": "T"}, {"family": "Marckmann", "given": "Georg", "initials": "G"}, {"family": "Munthe", "given": "Christian", "initials": "C"}, {"family": "Wild", "given": "Verina", "initials": "V"}], "type": "journal article", "published": "2020-10-21", "journal": {"title": "Ethics Inf Technol", "issn": "1388-1957", "volume": null, "issue": null, "pages": "1-10", "issn-l": null}, "abstract": "There is growing interest in contact tracing apps (CT apps) for pandemic management. It is crucial to consider ethical requirements before, while, and after implementing such apps. In this paper, we illustrate the complexity and multiplicity of the ethical considerations by presenting an ethical framework for a responsible design and implementation of CT apps. Using this framework as a starting point, we briefly highlight the interconnection of social and political contexts, available measures of pandemic management, and a multi-layer assessment of CT apps. We will discuss some trade-offs that arise from this perspective. We then suggest that public trust is of major importance for population uptake of contact tracing apps. Hasty, ill-prepared or badly communicated implementations of CT apps will likely undermine public trust, and as such, risk impeding general effectiveness.", "doi": "10.1007/s10676-020-09566-8", "pmid": "33106749", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "9566"}, {"db": "pmc", "key": "PMC7577205"}], "notes": [], "created": "2020-12-01T15:24:55.558Z", "modified": "2020-12-01T15:25:07.393Z"}, {"entity": "publication", "iuid": "6be39116f72544b68d8d9dc7977d08a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6be39116f72544b68d8d9dc7977d08a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6be39116f72544b68d8d9dc7977d08a6"}}, "title": "International Sexual Health And REproductive health (I-SHARE) survey during COVID-19: study protocol for online national surveys and global comparative analyses.", "authors": [{"family": "Michielsen", "given": "Kristien", "initials": "K"}, {"family": "Larrson", "given": "Elin C", "initials": "EC"}, {"family": "K\u00e5gesten", "given": "Anna", "initials": "A"}, {"family": "Erausquin", "given": "Jennifer Toller", "initials": "JT"}, {"family": "Griffin", "given": "Sally", "initials": "S"}, {"family": "Van de Velde", "given": "Sarah", "initials": "S"}, {"family": "Tucker", "given": "Joseph D", "initials": "JD"}, {"family": "I-SHARE Team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-10-20", "journal": {"title": "Sex Transm Infect", "issn": "1472-3263", "volume": null, "issue": null, "issn-l": "1368-4973"}, "abstract": "COVID-19 may have a profound impact on sexual health, reproductive health and social life across the world. Shelter in place regulations that have extended across the globe may influence condomless sex, exacerbate intimate partner violence and reduce access to essential reproductive health services. Population representative research is challenging during shelter in place, leaving major gaps in our understanding of sexual and reproductive health during COVID-19. This International Sexual Health And ReproductivE health (I-SHARE) study protocol manuscript describes a common plan for online national surveys and global comparative analyses.\n\nThe purpose of this cross-sectional study is to better understand sexual and reproductive health in selected countries during the COVID-19 pandemic and facilitate multinational comparisons. Participants will be recruited through an online survey link disseminated through local, regional and national networks. In each country, a lead organisation will be responsible for organising ethical review, translation and survey administration. The consortium network provides support for national studies, coordination and multinational comparison. We will use multilevel modelling to determine the relationship between COVID-19 and condomless sex, intimate partner violence, access to reproductive health services, HIV testing and other key items. This study protocol defines primary outcomes, prespecified subanalyses and analysis plans.\n\nThe I-SHARE study examines sexual and reproductive health at the national and global level during the COVID-19 pandemic. We will use multilevel modelling to investigate country-level variables associated with outcomes of interest. This will provide a foundation for subsequent online multicountry comparison using more robust sampling methodologies.", "doi": "10.1136/sextrans-2020-054664", "pmid": "33082232", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "sextrans-2020-054664"}], "notes": [], "created": "2020-11-26T12:36:06.646Z", "modified": "2020-12-01T15:41:25.096Z"}, {"entity": "publication", "iuid": "3770f7604a374d3992aa913a910ac25d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3770f7604a374d3992aa913a910ac25d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3770f7604a374d3992aa913a910ac25d"}}, "title": "COVID-19 outbreak-related psychological distress among healthcare trainees: a cross-sectional study in China.", "authors": [{"family": "Wang", "given": "Yue", "initials": "Y"}, {"family": "Li", "given": "Yuchen", "initials": "Y"}, {"family": "Jiang", "given": "Jingwen", "initials": "J"}, {"family": "Feng", "given": "Yuying", "initials": "Y"}, {"family": "Lu", "given": "Donghao", "initials": "D"}, {"family": "Zhang", "given": "Wei", "initials": "W"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "journal article", "published": "2020-10-20", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "10", "issue": "10", "pages": "e041671"}, "abstract": "The COVID-19 outbreak has caused enormous strain on healthcare systems, and healthcare trainees, which comprise the future healthcare workforce, may be a vulnerable group. It is essential to assess the psychological distress experienced by healthcare trainees during the COVID-19 outbreak.\r\n\r\nA cross-sectional study with 4184 healthcare trainees at Sichuan University in China was implemented during 7-13 February 2020. Participants were grouped by training programmes (medicine, medical technology and nursing) and training stages (undergraduate, postgraduate and residency).\r\n\r\nCOVID-19-related psychological distress and acute stress reaction (ASR) were assessed using the Kessler 6-item Psychological Distress Scale and the Impact of Event Scale-Revised, respectively. We estimated the ORs of distress by comparing trainees across programmes and training stages using multivariable logistic regression.\r\n\r\nSignificant psychological distress was found in 1150 (30.90%) participants and probable ASR in 403 (10.74%). Compared with the nursing trainees, the medical trainees (OR 1.54, 95% CI 1.22 to 1.95) reported a higher burden of psychological distress during the outbreak, while the medical technology trainees (OR 1.25, 95% CI 0.97 to 1.62) reported similar symptom scores. Postgraduates (OR 1.55, 95% CI 1.16 to 2.08) in medicine had higher levels of distress than their undergraduate counterparts did, whereas the nursing residents (OR 0.38, 95% CI 0.20 to 0.71) reported a lower burden than did nursing undergraduates. A positive association was found between having active clinical duties during the outbreak and distress (OR 1.17, 95% CI 0.98 to 1.39), particularly among the medical trainees (OR 1.85, 95% CI 1.47 to 2.33) and undergraduates (OR 4.20, 95% CI 1.61 to 11.70). No clear risk patterns of ASR symptoms were observed.\r\n\r\nMedical trainees, particularly postgraduates and those with active clinical duties, were at risk for psychological distress during the COVID-19 outbreak. Stress management may be considered for high-risk healthcare trainees.", "doi": "10.1136/bmjopen-2020-041671", "pmid": "33082197", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-041671"}, {"db": "pmc", "key": "PMC7577057"}], "notes": [], "created": "2020-12-01T15:42:02.339Z", "modified": "2022-11-09T08:45:01.712Z"}, {"entity": "publication", "iuid": "9184c2b13df3405285a42ea6ea4c942a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9184c2b13df3405285a42ea6ea4c942a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9184c2b13df3405285a42ea6ea4c942a"}}, "title": "Refugees in Sweden During the Covid-19 Pandemic-The Need for a New Perspective on Health and Integration.", "authors": [{"family": "Elisabeth", "given": "Mangrio", "initials": "M"}, {"family": "Maneesh", "given": "Paul-Satyaseela", "initials": "PS"}, {"family": "Michael", "given": "Strange", "initials": "S"}], "type": "journal article", "published": "2020-10-19", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "574334", "issn-l": "2296-2565"}, "abstract": "Refugees are already a vulnerable group in society and are in a stressful situation due to their often uncertain legal status in seeking asylum and integration in the new society after migration. Refugees are, in general, at greater risk of poor health outcomes when contracting Covid-19, exacerbated by poor living conditions and difficulties in accessing healthcare. The longer-term social consequences of the pandemic also disproportionately impact refugees, including social isolation, unemployment, and difficulties to obtain correct health information. The aim of this paper is to review the social and health consequences that Covid-19 has brought to the refugees residing in Sweden. This needs to be emphasized in order to mitigate against these likely consequences and improve the overall well-being among such a highly vulnerable group in society. As Covid-19 demonstrates, human health needs to be understood holistically, meaning that the vulnerability of any individuals, or even nations, is a vulnerability for the whole population requiring urgent action.", "doi": "10.3389/fpubh.2020.574334", "pmid": "33194974", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7604301"}], "notes": [], "created": "2020-11-27T11:01:13.351Z", "modified": "2023-01-13T13:52:25.482Z"}, {"entity": "publication", "iuid": "9aed2029c548476eae887740c14ca236", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9aed2029c548476eae887740c14ca236.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9aed2029c548476eae887740c14ca236"}}, "title": "Management of patients with chronic rhinosinusitis during the COVID-19 pandemic - An EAACI Position Paper.", "authors": [{"family": "Klimek", "given": "L", "initials": "L"}, {"family": "Jutel", "given": "M", "initials": "M"}, {"family": "Bousquet", "given": "J", "initials": "J"}, {"family": "Agache", "given": "I", "initials": "I"}, {"family": "Akdis", "given": "C", "initials": "C"}, {"family": "Hox", "given": "V", "initials": "V"}, {"family": "Gevaert", "given": "P", "initials": "P"}, {"family": "Tomazic", "given": "P V", "initials": "PV"}, {"family": "Rondon", "given": "C", "initials": "C"}, {"family": "Cingi", "given": "C", "initials": "C"}, {"family": "Toppila-Salmi", "given": "S", "initials": "S"}, {"family": "Karavelia", "given": "A", "initials": "A"}, {"family": "Bozkurt", "given": "B", "initials": "B"}, {"family": "F\u00f6rster-Ruhrmann", "given": "U", "initials": "U"}, {"family": "Becker", "given": "S", "initials": "S"}, {"family": "Chaker", "given": "A M", "initials": "AM"}, {"family": "Wollenberg", "given": "B", "initials": "B"}, {"family": "M\u00f6sges", "given": "R", "initials": "R"}, {"family": "Huppertz", "given": "T", "initials": "T"}, {"family": "Hagemann", "given": "J", "initials": "J"}, {"family": "Bachert", "given": "C", "initials": "C"}, {"family": "Fokkens", "given": "W", "initials": "W"}], "type": "journal article", "published": "2020-10-19", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": null, "issue": null, "issn-l": "0105-4538"}, "abstract": "CRS is regarded as a chronic airway disease. According to WHO recommendations, it may be a risk factor for COVID-19 patients. In most CRSwNP cases, the inflammatory changes affecting the nasal and paranasal mucous membranes are type-2 (T2) inflammation endotypes.\n\nThe current knowledge on COVID-19 and on treatment options for CRS was analyzed by a literature search in Medline, Pubmed, international guidelines, the Cochrane Library and the Internet.\n\nBased on international literature, on current recommendations by WHO and other international organizations as well as on previous experience, a panel of experts from EAACI and ARIA provided recommendations for the treatment of CRS during the COVID-19 pandemic.\n\nIntranasal corticosteroids remain the standard treatment for CRS in patients with SARS-CoV-2 infection. Surgical treatments should be reduced to a minimum and surgery preserved for patients with local complications and for those with no other treatment options. Systemic corticosteroids should be avoided. Treatment with biologics can be continued with careful monitoring in non-infected patients and should be temporarily interrupted during the course of the COVID-19 infection.", "doi": "10.1111/all.14629", "pmid": "33075144", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-01T16:58:38.839Z", "modified": "2020-12-01T16:58:38.850Z"}, {"entity": "publication", "iuid": "05886c693526485f80fe8f4503151ef0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/05886c693526485f80fe8f4503151ef0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/05886c693526485f80fe8f4503151ef0"}}, "title": "Effect of COVID-19 pandemic on treatment of Type 1 diabetes in children.", "authors": [{"family": "Ludvigsson", "given": "Johnny", "initials": "J"}], "type": "journal article", "published": "2020-10-19", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": null, "issue": null, "pages": null}, "abstract": "Brief report", "doi": "10.1111/apa.15627", "pmid": "33073367", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-01T16:59:59.808Z", "modified": "2020-12-01T17:00:40.121Z"}, {"entity": "publication", "iuid": "70d4934c27434293805e8ae5fb7722b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70d4934c27434293805e8ae5fb7722b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70d4934c27434293805e8ae5fb7722b4"}}, "title": "Antibody responses to SARS-CoV-2 train machine learning to assign likelihood of past infection during virus emergence in Sweden", "authors": [{"family": "Castro Dopico", "given": "Xaqu\u00edn", "initials": "X"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Sheward", "given": "Daniel J.", "initials": "DJ"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Christian", "given": "Murray", "initials": "M"}, {"family": "Grinberg", "given": "Nastasiya F.", "initials": "NF"}, {"family": "Adori", "given": "Monika", "initials": "M"}, {"family": "Perez Vidakovics", "given": "Laura", "initials": "L"}, {"family": "Kim", "given": "ChangIl", "initials": "C"}, {"family": "Khoenkhoen", "given": "Sharesta", "initials": "S"}, {"family": "Pushparaj", "given": "Pradeepa", "initials": "P"}, {"family": "Moliner Morro", "given": "Ainhoa", "initials": "A"}, {"family": "Mandolesi", "given": "Marco", "initials": "M"}, {"family": "Ahl", "given": "Marcus", "initials": "M"}, {"family": "Forsell", "given": "Mattias", "initials": "M"}, {"family": "Coquet", "given": "Jonathan", "initials": "J"}, {"family": "Corcoran", "given": "Martin", "initials": "M"}, {"family": "Rorbach", "given": "Joanna", "initials": "J"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Allander", "given": "Tobias", "initials": "T"}, {"family": "Wallace", "given": "Chris", "initials": "C"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Karlsson Hedestam", "given": "Gunilla B.", "initials": "GB"}], "type": "posted-content", "published": "2020-10-19", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Serology is critical for understanding pathogen-specific immune responses, but is fraught with difficulty, not least because the strength of antibody (Ab) response varies greatly between individuals and mild infections generally generate lower Ab titers (1-3). We used robust IgM, IgG and IgA Ab tests to evaluate anti-SARS-CoV-2 responses in individuals PCR+ for virus RNA (n=105) representing different categories of disease severity, including mild cases. All PCR+ individuals in the study became IgG-positive against pre-fusion trimers of the virus spike (S) glycoprotein, but titers varied greatly. Elevated IgA, IL-6 and neutralizing responses were present in intensive care patients. Additionally, blood donors and pregnant women (n=2,900) sampled throughout the first wave of the pandemic in Stockholm, Sweden, further demonstrated that anti-S IgG titers differed several orders of magnitude between individuals, with an increase of low titer values present in the population at later time points (4,5). To improve upon current methods to identify low titers and extend the utility of individual measures (6,7), we used our PCR+ individual data to train machine learning algorithms to assign likelihood of past infection. Using these tools that assigned probability to individual responses against S and the receptor binding domain (RBD), we report SARS-CoV-2-specific IgG in 13.7% of healthy donors five months after the peak of spring COVID-19 deaths, when mortality and ICU occupancy in the country due to the virus were at low levels. These data further our understanding of antibody responses to the virus and provide solutions to problems in serology data analysis.", "doi": "10.1101/2020.07.17.20155937", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://github.com/MurrellGroup/DiscriminativeSeroprevalence/", "description": "Inferring seroprevalence from ELISA data, without choosing a cutoff"}], "notes": [], "created": "2020-10-30T11:57:22.549Z", "modified": "2021-02-26T08:45:48.314Z"}, {"entity": "publication", "iuid": "925bb496b0f3481989389b307f005704", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/925bb496b0f3481989389b307f005704.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/925bb496b0f3481989389b307f005704"}}, "title": "Food Sovereignty of the Indigenous Peoples in the Arctic Zone of Western Siberia: Response to COVID-19 Pandemic.", "authors": [{"family": "Bogdanova", "given": "Elena", "initials": "E"}, {"family": "Andronov", "given": "Sergei", "initials": "S"}, {"family": "Morell", "given": "Ildiko Asztalos", "initials": "IA"}, {"family": "Hossain", "given": "Kamrul", "initials": "K"}, {"family": "Raheem", "given": "Dele", "initials": "D"}, {"family": "Filant", "given": "Praskovia", "initials": "P"}, {"family": "Lobanov", "given": "Andrey", "initials": "A"}], "type": "journal article", "published": "2020-10-18", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "20", "pages": null}, "abstract": "This article presents the challenges facing reindeer herding as being both a profitable business and part of the traditional culture of the nomadic Indigenous peoples in the Arctic zone of Western Siberia which addresses substantial needs of the local population. Reindeer herding products are used as traditional nutrition, and as effective preventive means and remedies for adapting to the cold and geomagnetic activity in the High North. Export trends of traditional reindeer products have decreased local Indigenous peoples' access to venison and had a negative impact on their health. Due to the COVID-19 pandemic, it is especially urgent for the Indigenous peoples to have sufficient access to traditional food and be involved in policy decision-making to maintain this traditional business. We aim to analyze the dependencies of Indigenous peoples on the reindeer produce-exporting \"food value chain\" and explore how (1) the independence of reindeer herders could be increased in these export chains and (2) how provision of their products to local communities could be secured. The study takes a multidisciplinary approach based on policy and socioeconomic analyses with input from medical research. Primary sources include data collected from interviews and surveys of Indigenous peoples during expeditions to the Nyda settlement, the Nydinskaya tundra, the Tazovsky settlement, the Tazovskaya tundra, the Nakhodka tundra, the Gyda and Gydansky settlements, the Yavai-Salinskaya tundra, the Seyakha settlement, the Seyakhinskaya and Tambeyskaya tundras located along the southern coast of the Ob Bay, the northeast coast of the Yamal Peninsula, the Tazovsky and Gydansky Peninsulas, and the Shuryshkarsky district. Data were collected during the summers and winters of 2014-2020.", "doi": "10.3390/ijerph17207570", "pmid": "33080982", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph17207570"}, {"db": "pmc", "key": "PMC7590208"}], "notes": [], "created": "2020-12-01T15:43:25.508Z", "modified": "2022-11-09T08:46:54.157Z"}, {"entity": "publication", "iuid": "267f1fcb0fb34478bf52e2fd9db96cd2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/267f1fcb0fb34478bf52e2fd9db96cd2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/267f1fcb0fb34478bf52e2fd9db96cd2"}}, "title": "Estimating total excess mortality during a COVID-19 outbreak in Stockholm, Sweden.", "authors": [{"family": "Pimenoff", "given": "Ville N", "initials": "VN"}, {"family": "Elfstr\u00f6m", "given": "Miriam", "initials": "M"}, {"family": "Baussano", "given": "Iacopo", "initials": "I"}, {"family": "Bj\u00f6rnstedt", "given": "Mikael", "initials": "M"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}], "type": "journal article", "published": "2020-10-18", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "issn-l": "1058-4838", "volume": null, "issue": null, "pages": null}, "abstract": "Total excess mortality peaked during a COVID19 outbreak in Stockholm, but 25% of these deaths were not recognized as Covid-19-related nor occurred in hospitals. Estimate of total excess mortality may give a more comprehensive picture of the total disease burden during a COVID19 outbreak, and may facilitate managing future outbreaks.", "doi": "10.1093/cid/ciaa1593", "pmid": "33070183", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "5929661"}, {"db": "pmc", "key": "PMC7665438"}], "notes": [], "created": "2020-11-18T16:48:58.988Z", "modified": "2021-02-26T08:45:47.953Z"}, {"entity": "publication", "iuid": "cfa37a55e8fc473d9a1938b3d880e236", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfa37a55e8fc473d9a1938b3d880e236.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfa37a55e8fc473d9a1938b3d880e236"}}, "title": "The COVID-19 pandemic and serious psychological consequences in Bangladesh: A population-based nationwide study.", "authors": [{"family": "Mamun", "given": "Mohammed A", "initials": "MA"}, {"family": "Sakib", "given": "Najmuj", "initials": "N"}, {"family": "Gozal", "given": "David", "initials": "D"}, {"family": "Bhuiyan", "given": "Akm Israfil", "initials": "AI"}, {"family": "Hossain", "given": "Sahadat", "initials": "S"}, {"family": "Bodrud-Doza", "given": "Md", "initials": "M"}, {"family": "Al Mamun", "given": "Firoj", "initials": "F"}, {"family": "Hosen", "given": "Ismail", "initials": "I"}, {"family": "Safiq", "given": "Mariam Binte", "initials": "MB"}, {"family": "Abdullah", "given": "Abu Hasnat", "initials": "AH"}, {"family": "Sarker", "given": "Md Abedin", "initials": "MA"}, {"family": "Rayhan", "given": "Istihak", "initials": "I"}, {"family": "Sikder", "given": "Md Tajuddin", "initials": "MT"}, {"family": "Muhit", "given": "Mohammad", "initials": "M"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2020-10-17", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "issn-l": null, "volume": "279", "issue": null, "pages": "462-472"}, "abstract": "As with other countries worldwide, lockdown measures during the COVID-19 outbreak in Bangladesh were sudden and unexpected, and have the capacity to elicit serious psychological consequences. The present study examined the psychological consequences of COVID-19 in Bangladesh during the lockdown period.\r\n\r\nA nationwide online cross-sectional survey study recruited 10,067 individuals covering all 64 districts in Bangladesh via social media (April 1-10, 2020). The survey comprised questions concerning socio-demographics, knowledge of COVID-19, behavior towards COVID-19, fear of COVID-19, insomnia, depression, and suicidal ideation. Logistic regression and structural equation modeling (SEM) analyses were performed to identify the risk factors depression and suicidal ideation. Geographical information system (GIS)-based spatial analysis was used to identify district-wise susceptibility to depression and suicidal ideation.\r\n\r\nThe prevalence rate of depression and suicidal ideation related to COVID-19 was 33% and 5%%. Common risk factors for suicidal ideation and depression included being young, being female, being a cigarette smoker, having comorbid diseases, having high scores on the Fear COVID-19 Scale, and having insomnia symptoms. GIS-based maps detected high depression and suicidal ideation in the capital of Bangladesh and the districts near the capital as well as coastal areas where COVID-19 prevalence was high, as compared with districts with no reported cases.\r\n\r\nSelf-reported scales and cross-sectional design of the study.\r\n\r\nCOVID-19 is associated with major psychological impact across Bangladesh, underlining the need of strategically located psychological support measures and improved access to mental health services, especially among women and younger people.", "doi": "10.1016/j.jad.2020.10.036", "pmid": "33120247", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0165-0327(20)32880-9"}, {"db": "pmc", "key": "PMC7568472"}], "notes": [], "created": "2020-12-01T15:09:02.752Z", "modified": "2022-11-09T08:48:33.526Z"}, {"entity": "publication", "iuid": "b550adb70b314df1a899f8f482650e72", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b550adb70b314df1a899f8f482650e72.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b550adb70b314df1a899f8f482650e72"}}, "title": "Rotational thromboelastometry results are associated with care level in COVID-19.", "authors": [{"family": "Almskog", "given": "Lou M", "initials": "LM"}, {"family": "Wikman", "given": "Agneta", "initials": "A"}, {"family": "Svensson", "given": "Jonas", "initials": "J"}, {"family": "Wanecek", "given": "Michael", "initials": "M"}, {"family": "Bottai", "given": "Matteo", "initials": "M"}, {"family": "van der Linden", "given": "Jan", "initials": "J"}, {"family": "\u00c5gren", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2020-10-17", "journal": {"title": "J Thromb Thrombolysis", "issn": "1573-742X", "volume": null, "issue": null, "issn-l": null}, "abstract": "High prevalence of thrombotic events in severely ill COVID-19 patients have been reported. Pulmonary embolism as well as microembolization of vital organs may in these individuals be direct causes of death. The identification of patients at high risk of developing thrombosis may lead to targeted, more effective prophylactic treatment. The primary aim of this study was to test whether rotational thromboelastometry (ROTEM) at admission indicates hypercoagulopathy and predicts the disease severity, assessed as care level, in COVID-19 patients. The study was designed as a prospective, observational study where COVID-19 patients over 18 years admitted to hospital were eligible for inclusion. Patients were divided into two groups depending on care level: (1) regular wards or (2) wards with specialized ventilation support. Conventional coagulation tests, blood type and ROTEM were taken at admission. 60 patients were included; age 61 (median), 67% men, many with comorbidities (e.g. hypertension, diabetes). The ROTEM variables Maximum Clot Firmness (EXTEM-/FIBTEM-MCF) were higher in COVID-19 patients compared with in healthy controls (p < 0.001) and higher in severely ill patients compared with in patients at regular wards (p < 0.05). Our results suggest that hypercoagulopathy is present early in patients with mild to moderate disease, and more pronounced in severe COVID-19 pneumonia. Non-O blood types were not overrepresented in COVID-19 positive patients. ROTEM variables showed hypercoagulopathy at admission and this pattern was more pronounced in patients with increased disease severity. If this feature is to be used to predict the risk of thromboembolic complications further studies are warranted.", "doi": "10.1007/s11239-020-02312-3", "pmid": "33068277", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.5878/wh80-0w17", "description": "Raw data"}], "notes": [], "created": "2020-12-01T17:06:38.593Z", "modified": "2021-02-26T08:45:48.601Z"}, {"entity": "publication", "iuid": "bd8661a4c7074ab29dc024d662305526", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bd8661a4c7074ab29dc024d662305526.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bd8661a4c7074ab29dc024d662305526"}}, "title": "Harmonization of antineutrophil cytoplasmic antibodies (ANCA) testing by reporting test result-specific likelihood ratios: position paper.", "authors": [{"family": "Bossuyt", "given": "Xavier", "initials": "X"}, {"family": "Damoiseaux", "given": "Jan", "initials": "J"}, {"family": "Rasmussen", "given": "Niels", "initials": "N"}, {"family": "van Paassen", "given": "Pieter", "initials": "P"}, {"family": "Hellmich", "given": "Bernard", "initials": "B"}, {"family": "Baslund", "given": "Bo", "initials": "B"}, {"family": "Blockmans", "given": "Daniel", "initials": "D"}, {"family": "Vermeersch", "given": "Pieter", "initials": "P"}, {"family": "Lopez-Hoyos", "given": "Marcos", "initials": "M"}, {"family": "Vercammen", "given": "Martine", "initials": "M"}, {"family": "Barret", "given": "Elisa", "initials": "E"}, {"family": "Hammar", "given": "Friederike", "initials": "F"}, {"family": "Leinfelder", "given": "Ulrich", "initials": "U"}, {"family": "Mahler", "given": "Michael", "initials": "M"}, {"family": "Olschowka", "given": "Nina", "initials": "N"}, {"family": "Roggenbuck", "given": "Dirk", "initials": "D"}, {"family": "Schlumberger", "given": "Wolfgang", "initials": "W"}, {"family": "Walker", "given": "Roger", "initials": "R"}, {"family": "R\u00f6nnelid", "given": "Johan", "initials": "J"}, {"family": "Cohen Tervaert", "given": "Jan-Willem", "initials": "JW"}, {"family": "Csernok", "given": "Elena", "initials": "E"}, {"family": "Fierz", "given": "Walter", "initials": "W"}, {"family": "for (i) the European Federation of Laboratory Medicine (EFLM) Task and Finish Group \u201cAutoimmunity Testing,\u201d (ii) the European Autoimmune Standardization Initiative (EASI) and the (iii) European Consensus Finding Study Group on autoantibodies (ECFSG)", "given": "", "initials": ""}], "type": "letter", "published": "2020-10-16", "journal": {"title": "Clin Chem Lab Med", "issn": "1437-4331", "volume": null, "issue": null, "issn-l": "1434-6621"}, "abstract": null, "doi": "10.1515/cclm-2020-1178", "pmid": "33027040", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "/j/cclm.ahead-of-print/cclm-2020-1178/cclm-2020-1178.xml"}], "notes": [], "created": "2020-11-19T19:46:53.265Z", "modified": "2021-02-26T08:46:13.472Z"}, {"entity": "publication", "iuid": "6bae92ff5cf94413903de7a063df791d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6bae92ff5cf94413903de7a063df791d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6bae92ff5cf94413903de7a063df791d"}}, "title": "Asthma and severe acute respiratory syndrome coronavirus 2019: current evidence and knowledge gaps.", "authors": [{"family": "Assaf", "given": "Sara M", "initials": "SM"}, {"family": "Tarasevych", "given": "Svitlana P", "initials": "SP"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}, {"family": "Hanania", "given": "Nicola A", "initials": "NA"}], "type": "journal article", "published": "2020-10-16", "journal": {"title": "Curr Opin Pulm Med", "issn": "1531-6971", "volume": null, "issue": null, "issn-l": "1070-5287"}, "abstract": "Although respiratory viruses are common triggers of asthma exacerbation, it is unknown whether this also applies to infection with SARS-CoV-2. Indeed, patients with asthma and allergy appear underrepresented in large reports of COVID-19 cases worldwide. In this review, we evaluate existing literature on this topic and potential underlying mechanisms for any interrelationship between asthma and COVID-19.\n\nData from several preclinical and clinical reports suggest a lower susceptibility for COVID-19 in patients with underlying type 2 airway inflammation including asthma that may be related to a reduced expression of ACE2 and TMPRSS2 receptors for SARS-CoV-2. Corticosteroids further decrease expression of the ACE2 and TMPRSS2 receptors, hence may also have a protective effect against infection with SARS-CoV-2. In addition, some studies suggest that the reported improvement in asthma control and a reduction in asthma exacerbations during the COVID-19 pandemic may be related to improvement in adherence to controller therapy and reduced exposure to triggers, such as other respiratory viruses and air pollutants. Recent data point towards differential susceptibility for COVID-19 among asthma patients based on their phenotype and/or endotype. On the basis of existing evidence, continuation with controller therapies is recommended for all patients with asthma. For patients with severe uncontrolled asthma infected by SARS-CoV-2, adjustment of controllers and biologics should be based on a multidisciplinary decision.\n\nUnderrepresentation of SARS-CoV-2-infected patients with asthma and related allergic diseases may be based on potentially protective underlying mechanisms, such as type 2 airway inflammation, downregulation of ACE2/TMPRSS2 receptors, reduced exposures to triggers and improved adherence to controller medications. Although it is imperative that control should be maintained and asthma medications be continued in all patients, management of patients with severe uncontrolled asthma infected by SARS-CoV-2 including adjustment of controllers and biologics should be discussed on an individual basis.", "doi": "10.1097/MCP.0000000000000744", "pmid": "33065601", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-27T11:51:37.680Z", "modified": "2020-11-27T12:38:55.348Z"}, {"entity": "publication", "iuid": "6854c632851b4cf8a636d73aa8c35e0f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6854c632851b4cf8a636d73aa8c35e0f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6854c632851b4cf8a636d73aa8c35e0f"}}, "title": "The Impact of the German Strategy for Containment of Coronavirus SARS-CoV-2 on Training Characteristics, Physical Activity and Sleep of Highly Trained Kayakers and Canoeists: A Retrospective Observational Study.", "authors": [{"family": "Zinner", "given": "Christoph", "initials": "C"}, {"family": "Matzka", "given": "Manuel", "initials": "M"}, {"family": "Leppich", "given": "Robert", "initials": "R"}, {"family": "Kounev", "given": "Samuel", "initials": "S"}, {"family": "Holmberg", "given": "Hans-Christer", "initials": "HC"}, {"family": "Sperlich", "given": "Billy", "initials": "B"}], "type": "journal article", "published": "2020-10-15", "journal": {"title": "Front Sports Act Living", "issn": "2624-9367", "volume": "2", "issue": null, "pages": "579830", "issn-l": null}, "abstract": "Aim: To characterize the impact of the German strategy for containment of Coronavirus SARS-CoV-2 (social distancing and lockdown) on the training, other habitual physical activity, and sleep in highly trained kayakers and canoeists. Method: During the 4 weeks immediately prior to and following the beginning of the German government's strategy for containment of Coronavirus SARS-CoV-2 on March 23, 2020, 14 highly trained athletes (VO2peak: 3,162 \u00b1 774 ml/min; 500-m best time: 117.9 \u00b1 7.9 s) wore a multi-sensor smartwatch to allow continuous assessment of heart rate, physical activity, and sleep duration. Result: In comparison to before lockdown, the overall weekly training time and the average length of each session of training during the lockdown decreased by 27.6% (P = 0.02; d = 0.91) and 15.4% (P = 0.36; d = 0.36), respectively. At the same time, the number of sessions involving specific (i.e., canoeing and kayaking) and non-specific (i.e., running, cycling) training, respectively, did not change (P = 0.36-0.37; d = 0.34-0.35). The number of sessions involving strength (+17.4%; P = 0.03; d = 0.89) or other types of training (+16.7%; P = 0.06; d = 0.75) increased during the lockdown with 2.8-17.5% more training time involving a heart rate <60%, 82-88, 89-93, or 94-100% of individual peak heart rate (HRpeak) (P = 0.03-0.86; d = 0.07-1.38), and 4.3-18.7% less time with a heart rate of 60-72 or 73-83% HRpeak (P = < 0.001-0.0.26; d = 0.44-2.24). The daily duration of sleep was ~30 min (6.7%) longer during the lockdown (P < 0.001; d = 1.53) and the overall time spent lying down was 17% greater (P < 0.001; d = 2.26); whereas sitting time (-9.4%; P = 0.003; d = 1.23), the duration of light (15 min; -7.3%; P = 0.04; d = 0.83), and moderate (-18.6%; P = 0.01; d = 1.00) physical activity other than training (-9.4%; P = 0.22; d = 0.00) were all lower during lockdown. Conclusion: The present data revealed that following the German lockdown for containment of the Coronavirus SARS-CoV-2, highly trained kayakers and canoeists spent less overall time training each week (-27.6%) with, on average, shorter training sessions (-15.1%) and less light-to-moderate physical activity outside of training. Moreover, they performed more strength training sessions per week, and all engaged in more training at intensities >82 and <60% of HRpeak and spent longer periods lying down and sleeping during the lockdown.", "doi": "10.3389/fspor.2020.579830", "pmid": "33345147", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7739795"}], "notes": [], "created": "2021-01-07T13:29:20.028Z", "modified": "2023-06-19T14:55:02.352Z"}, {"entity": "publication", "iuid": "adafb3508b7648b9860b5e515ac65d25", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/adafb3508b7648b9860b5e515ac65d25.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/adafb3508b7648b9860b5e515ac65d25"}}, "title": "Satellite-detected tropospheric nitrogen dioxide and spread of SARS-CoV-2 infection in Northern Italy.", "authors": [{"family": "Filippini", "given": "Tommaso", "initials": "T"}, {"family": "Rothman", "given": "Kenneth J", "initials": "KJ"}, {"family": "Goffi", "given": "Alessia", "initials": "A"}, {"family": "Ferrari", "given": "Fabrizio", "initials": "F"}, {"family": "Maffeis", "given": "Giuseppe", "initials": "G"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}, {"family": "Vinceti", "given": "Marco", "initials": "M"}], "type": "journal article", "published": "2020-10-15", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "volume": "739", "issue": null, "pages": "140278", "issn-l": "0048-9697"}, "abstract": "Following the outbreak of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) last December 2019 in China, Italy was the first European country to be severely affected, with the first local case diagnosed on 20 February 2020. The virus spread quickly, particularly in the North of Italy, with three regions (Lombardy, Veneto and Emilia-Romagna) being the most severely affected. These three regions accounted for >80% of SARS-CoV-2 positive cases when the tight lockdown was established (March 8). These regions include one of Europe's areas of heaviest air pollution, the Po valley. Air pollution has been recently proposed as a possible risk factor of SARS-CoV-2 infection, due to its adverse effect on immunity and to the possibility that polluted air may even carry the virus. We investigated the association between air pollution and subsequent spread of the SARS-CoV-2 infection within these regions. We collected NO 2 tropospheric levels using satellite data available at the European Space Agency before the lockdown. Using a multivariable restricted cubic spline regression model, we compared NO2 levels with SARS-CoV-2 infection prevalence rate at different time points after the lockdown, namely March 8, 22 and April 5, in the 28 provinces of Lombardy, Veneto and Emilia-Romagna. We found little association of NO2 levels with SARS-CoV-2 prevalence up to about 130 \u03bcmol/m2, while a positive association was evident at higher levels at each time point. Notwithstanding the limitations of the use of aggregated data, these findings lend some support to the hypothesis that high levels of air pollution may favor the spread of the SARS-CoV-2 infection.", "doi": "10.1016/j.scitotenv.2020.140278", "pmid": "32758963", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(20)33799-2"}, {"db": "pmc", "key": "PMC7297152"}], "notes": [], "created": "2020-12-07T15:43:31.840Z", "modified": "2020-12-07T15:43:31.851Z"}, {"entity": "publication", "iuid": "71feecb0597d4021a3035ca71bab259e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/71feecb0597d4021a3035ca71bab259e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/71feecb0597d4021a3035ca71bab259e"}}, "title": "SARS-CoV-2 (COVID-19) infection in pregnant women: characterization of symptoms and syndromes predictive of disease and severity through real-time, remote participatory epidemiology.", "authors": [{"family": "Molteni", "given": "Erika", "initials": "E", "orcid": "0000-0001-7773-8140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9aed1fbe444b48d4bfacb12050953c8e.json"}}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Sudre", "given": "Carole H", "initials": "CH", "orcid": "0000-0001-5753-428X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c26472813fed4007a8757af771de1802.json"}}, {"family": "Magee", "given": "Laura A", "initials": "LA", "orcid": "0000-0002-1355-610X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ee8a639fe1c489887b631cec86a872d.json"}}, {"family": "Murray", "given": "Benjamin", "initials": "B"}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f34c0d3602439abe6096293c7c732d.json"}}, {"family": "Gomez", "given": "Maria F", "initials": "MF", "orcid": "0000-0001-6210-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e09e37219c4f42c8a7b3a982da523859.json"}}, {"family": "Tsereteli", "given": "Neli", "initials": "N"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Brownstein", "given": "John S", "initials": "JS", "orcid": "0000-0001-8568-5317", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2be459b61ae457e8fdcef38a0bc4cf7.json"}}, {"family": "Davies", "given": "Richard", "initials": "R"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Ourselin", "given": "Sebastien", "initials": "S", "orcid": "0000-0002-5694-5340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74c7b9b1633144879042d198c7205656.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "Modat", "given": "Marc", "initials": "M", "orcid": "0000-0002-5277-8530", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/794a8484b16a4a42a35c505688018eb1.json"}}], "type": "preprint", "published": "2020-10-14", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To test whether pregnant and non-pregnant women differ in COVID-19 symptom profile and severity. To extend previous investigations on hospitalized pregnant women to those who did not require hospitalization.\n\nObservational study prospectively collecting longitudinal (smartphone application interface) and cross-sectional (web-based survey) data.\n\nCommunity-based self-participatory citizen surveillance in the United Kingdom, Sweden and the United States of America.\n\nTwo female community-based cohorts aged 18-44 years. The discovery cohort was drawn from 1,170,315 UK, Sweden and USA women (79 pregnant tested positive) who self-reported status and symptoms longitudinally via smartphone. The replication cohort included 1,344,966 USA women (134 pregnant tested positive) who provided cross-sectional self-reports.\n\nPregnant and non-pregnant were compared for frequencies of symptoms and events, including SARS-CoV-2 testing and hospitalization rates. Multivariable regression was used to investigate symptoms severity and comorbidity effects.\n\nPregnant and non-pregnant women positive for SARS-CoV-2 infection were not different in syndromic severity. Pregnant were more likely to have received testing than non-pregnant, despite reporting fewer symptoms. Pre-existing lung disease was most closely associated with the syndromic severity in pregnant hospitalized women. Heart and kidney diseases and diabetes increased risk. The most frequent symptoms among all non-hospitalized women were anosmia [63% pregnant, 92% non-pregnant] and headache [72%, 62%]. Cardiopulmonary symptoms, including persistent cough [80%] and chest pain [73%], were more frequent among pregnant women who were hospitalized.\n\nSymptom characteristics and severity were comparable among pregnant and non-pregnant women, except for gastrointestinal symptoms. Consistent with observations in non-pregnant populations, lung disease and diabetes were associated with increased risk of more severe SARS-CoV-2 infection during pregnancy.", "doi": "10.1101/2020.08.17.20161760", "pmid": "32839787", "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7444306"}, {"db": "pii", "key": "2020.08.17.20161760"}], "notes": [], "created": "2020-12-07T10:29:38.783Z", "modified": "2023-06-19T15:08:12.850Z"}, {"entity": "publication", "iuid": "921293bc4dd94ced8c6db449251f6eae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/921293bc4dd94ced8c6db449251f6eae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/921293bc4dd94ced8c6db449251f6eae"}}, "title": "Rethinking developed nations' health systems through a social sustainability perspective in the light of the COVID-19 pandemic. A viewpoint.", "authors": [{"family": "Macassa", "given": "Gloria", "initials": "G"}, {"family": "Tomaselli", "given": "Gianpaolo", "initials": "G"}], "type": "journal article", "published": "2020-10-14", "journal": {"title": "J Public Health Res", "issn": "2279-9028", "volume": "9", "issue": "4", "pages": "1834", "issn-l": null}, "abstract": "This viewpoint paper argues for the need for more socially sustainable care systems that can better contribute to equitable utilization of health care in a post-pandemic era. Health care systems in developed nations need to rethink their role, particularly with regard to the achievement of Sustainable Development Goal 3 (SDG 3) as well as becoming more sustainable societies. Socially sustainable care systems will recognize that systemic factors and processes (social, economic, environmental, cultural) need to be addressed simultaneously in order to achieve health equity. Moreover, these systems are likely to be of paramount importance for post-COVID-19, because of the potential increase in demand for health care due to forgone health care and the increased burden of chronic diseases as spillover effects related to COVID-19 mitigation interventions.", "doi": "10.4081/jphr.2020.1834", "pmid": "33209860", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7649672"}], "notes": [], "created": "2020-11-30T16:11:49.861Z", "modified": "2020-11-30T16:11:49.885Z"}, {"entity": "publication", "iuid": "e8e888fa0a634256b20d6587ef48b94c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e8e888fa0a634256b20d6587ef48b94c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e8e888fa0a634256b20d6587ef48b94c"}}, "title": "Global impact of COVID-19 on non-communicable disease management: descriptive analysis of access to FRAX fracture risk online tool for prevention of osteoporotic fractures.", "authors": [{"family": "McCloskey", "given": "E V", "initials": "EV"}, {"family": "Harvey", "given": "N C", "initials": "NC"}, {"family": "Johansson", "given": "H", "initials": "H"}, {"family": "Lorentzon", "given": "M", "initials": "M"}, {"family": "Vandenput", "given": "L", "initials": "L"}, {"family": "Liu", "given": "E", "initials": "E"}, {"family": "Kanis", "given": "J A", "initials": "JA"}], "type": "journal article", "published": "2020-10-14", "journal": {"title": "Osteoporos Int", "issn": "1433-2965", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic, and its management, is markedly impacting the management of osteoporosis as judged by access to online FRAX fracture risk assessments. Globally, access was 58% lower in April than in February 2020. Strategies to improve osteoporosis care, with greater use of fracture risk assessments, offer a partial solution.\r\n\r\nThe COVID-19 pandemic is having a significant detrimental impact on the management of chronic diseases including osteoporosis. We have quantified the global impact by examining changes in the usage of online FRAX fracture risk assessments before and after the declaration of the pandemic (11 March 2020).\r\n\r\nThe study comprised a retrospective analysis using GoogleAnalytics data on daily sessions on the FRAX\u00ae website ( www.sheffield.ac.uk/FRAX ) from November 2019 to April 2020 (main analysis period February-April 2020), and the geographical source of that activity.\r\n\r\nOver February-April 2020, the FRAX website recorded 460,495 sessions from 184 countries, with 210,656 sessions in February alone. In March and April, the number of sessions fell by 23.1% and 58.3% respectively, a pattern not observed over the same period in 2019. There were smaller reductions in Asia than elsewhere, partly related to earlier and less-marked nadirs in some countries (China, Taiwan, Hong Kong, South Korea and Vietnam). In Europe, the majority of countries (24/31, 77.4%) reduced usage by at least 50% in April. Seven countries showed smaller reductions (range - 2.85 to - 44.1%) including Poland, Slovakia, Czech Republic, Germany, Norway, Sweden and Finland. There was no significant relationship between the reduction in FRAX usage and measures of disease burden such as COVID-attributed deaths per million of the population.\r\n\r\nThis study documents a marked global impact of the COVID-19 pandemic on the management of osteoporosis as reflected by FRAX online fracture risk assessments. The analysis suggests that impact may relate to the societal and healthcare measures taken to ameliorate the pandemic.", "doi": "10.1007/s00198-020-05542-6", "pmid": "33057738", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00198-020-05542-6"}, {"db": "pmc", "key": "PMC7556595"}], "notes": [], "created": "2020-12-01T17:11:07.268Z", "modified": "2022-11-09T08:54:18.900Z"}, {"entity": "publication", "iuid": "56017c8d0b4a4351a6f0654886292ba0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56017c8d0b4a4351a6f0654886292ba0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56017c8d0b4a4351a6f0654886292ba0"}}, "title": "Benchmarking virus concentration methods for quantification of SARS-CoV-2 in raw wastewater", "authors": [{"family": "Jafferali", "given": "Mohammed Hakim", "initials": "MH"}, {"family": "Khatami", "given": "Kasra", "initials": "K"}, {"family": "Atasoy", "given": "Merve", "initials": "M"}, {"family": "Birgersson", "given": "Madeleine", "initials": "M"}, {"family": "Williams", "given": "Cecilia", "initials": "C"}, {"family": "Cetecioglu", "given": "Zeynep", "initials": "Z"}], "type": "journal-article", "published": "2020-10-14", "journal": {"title": "Science of The Total Environment", "issn": "0048-9697", "issn-l": "0048-9697", "volume": "755", "issue": "Pt 1", "pages": "142939"}, "abstract": "Wastewater-based epidemiology offers a cost-effective alternative to testing large populations for SARS-CoV-2 virus, and may potentially be used as an early warning system for SARS-CoV-2 pandemic spread. However, viruses are highly diluted in wastewater, and a validated method for their concentration and further processing, and suitable reference viruses, are the main needs to be established for reliable SARS-CoV-2 municipal wastewater detection. For this purpose, we collected wastewater from two European cities during the Covid-19 pandemic and evaluated the sensitivity of RT-qPCR detection of viral RNA after four concentration methods (two variants of ultrafiltration-based method and two adsorption and extraction-based methods). Further, we evaluated one external (bovine corona virus) and one internal (pepper mild mottle virus) reference virus. We found a consistently higher recovery of spiked virus using the modified ultrafiltration-based method. This method also had a significantly higher efficiency (p-value <0.01) for wastewater SARS-CoV-2 detection. The ultracentrifugation method was the only method that detected SARS-CoV-2 in the wastewater of both cities. The pepper mild mottle virus was found to function as a potentially suitable internal reference standard.", "doi": "10.1016/j.scitotenv.2020.142939", "pmid": "33121776", "labels": {"Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Funder: VR": null, "Research Area: Environmental virus profiling": null}, "xrefs": [], "notes": [], "created": "2020-11-04T16:24:02.607Z", "modified": "2021-06-13T14:20:47.780Z"}, {"entity": "publication", "iuid": "11fc0facc2b6421f9c19355255e2c2a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/11fc0facc2b6421f9c19355255e2c2a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/11fc0facc2b6421f9c19355255e2c2a1"}}, "title": "A materials-science perspective on tackling COVID-19.", "authors": [{"family": "Tang", "given": "Zhongmin", "initials": "Z", "orcid": "0000-0002-1532-8004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c277e0db294d1dbf4cf183b78392cd.json"}}, {"family": "Kong", "given": "Na", "initials": "N"}, {"family": "Zhang", "given": "Xingcai", "initials": "X", "orcid": "0000-0001-7114-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c328b6119cf54f8589012b0add4f13ef.json"}}, {"family": "Liu", "given": "Yuan", "initials": "Y"}, {"family": "Hu", "given": "Ping", "initials": "P"}, {"family": "Mou", "given": "Shan", "initials": "S"}, {"family": "Liljestr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Shi", "given": "Jianlin", "initials": "J", "orcid": "0000-0001-8790-195X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9e484b2f7d5414585be457b42d13dba.json"}}, {"family": "Tan", "given": "Weihong", "initials": "W", "orcid": "0000-0002-8066-1524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc983c96b5874c20adf7a7e8c5e511be.json"}}, {"family": "Kim", "given": "Jong Seung", "initials": "JS"}, {"family": "Cao", "given": "Yihai", "initials": "Y"}, {"family": "Langer", "given": "Robert", "initials": "R", "orcid": "0000-0003-4255-0492", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ee4392159f340659f2e334c799dfd12.json"}}, {"family": "Leong", "given": "Kam W", "initials": "KW"}, {"family": "Farokhzad", "given": "Omid C", "initials": "OC"}, {"family": "Tao", "given": "Wei", "initials": "W", "orcid": "0000-0002-4277-3728", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5ed1e15ddf44fe4bfc6ad8d5cd35379.json"}}], "type": "journal article", "published": "2020-10-14", "journal": {"title": "Nat Rev Mater", "issn": "2058-8437", "volume": "5", "issue": "11", "pages": "847-860", "issn-l": "2058-8437"}, "abstract": "The ongoing SARS-CoV-2 pandemic highlights the importance of materials science in providing tools and technologies for antiviral research and treatment development. In this Review, we discuss previous efforts in materials science in developing imaging systems and microfluidic devices for the in-depth and real-time investigation of viral structures and transmission, as well as material platforms for the detection of viruses and the delivery of antiviral drugs and vaccines. We highlight the contribution of materials science to the manufacturing of personal protective equipment and to the design of simple, accurate and low-cost virus-detection devices. We then investigate future possibilities of materials science in antiviral research and treatment development, examining the role of materials in antiviral-drug design, including the importance of synthetic material platforms for organoids and organs-on-a-chip, in drug delivery and vaccination, and for the production of medical equipment. Materials-science-based technologies not only contribute to the ongoing SARS-CoV-2 research efforts but can also provide platforms and tools for the understanding, protection, detection and treatment of future viral diseases.", "doi": "10.1038/s41578-020-00247-y", "pmid": "33078077", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7556605"}, {"db": "pii", "key": "247"}], "notes": [], "created": "2020-11-26T12:20:01.618Z", "modified": "2023-06-19T14:36:07.995Z"}, {"entity": "publication", "iuid": "782ddc32ba1b4bafaf233aaa77d0e0d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/782ddc32ba1b4bafaf233aaa77d0e0d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/782ddc32ba1b4bafaf233aaa77d0e0d5"}}, "title": "The COVID-19 pandemic: The importance of physical activity among faculty members.", "authors": [{"family": "Fr\u00f6berg", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2020-10-13", "journal": {"title": "J Am Coll Health", "issn": "1940-3208", "issn-l": null, "volume": null, "issue": null, "pages": "1-4"}, "abstract": "The novel coronavirus (SARS-CoV-2) disease 2019 (COVID-19) pandemic has posed serious challenge to societies worldwide. To prevent person-to-person transmission of the coronavirus and avoid associated morbidity and mortality, several public health measures have been introduced by various health organizations and authorities, such as social distancing policies and quarantine. While necessary, these public health measures are likely to have implications for people's physical activity behaviors. This viewpoint is intended for faculty members and focus on the importance of physical activity for health. Suggestions on how to stay physically active during the COVID-19 pandemic are also provided.", "doi": "10.1080/07448481.2020.1817037", "pmid": "33048633", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-01T17:12:20.056Z", "modified": "2022-11-09T08:55:35.729Z"}, {"entity": "publication", "iuid": "a99bb5289fde46d39c4ab2f27181521a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a99bb5289fde46d39c4ab2f27181521a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a99bb5289fde46d39c4ab2f27181521a"}}, "title": "Registry reports in COVID-19 patients: Juggling with big data, poor data, and no data.", "authors": [{"family": "S\u00f8fteland", "given": "John Mackay", "initials": "JM"}, {"family": "Karason", "given": "Kristjan", "initials": "K"}, {"family": "Magnusson", "given": "Jesper", "initials": "J"}, {"family": "Schult", "given": "Andreas", "initials": "A"}, {"family": "Felldin", "given": "Marie", "initials": "M"}, {"family": "Friman", "given": "Vanda", "initials": "V"}, {"family": "Oltean", "given": "Mihai", "initials": "M"}], "type": "letter", "published": "2020-10-13", "journal": {"title": "Kidney Int", "issn": "1523-1755", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.kint.2020.09.017", "pmid": "33065132", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0085-2538(20)31181-9"}, {"db": "pmc", "key": "PMC7550855"}], "notes": [], "created": "2020-12-01T17:08:55.634Z", "modified": "2020-12-01T17:08:55.656Z"}, {"entity": "publication", "iuid": "a49fb892a93344f393c58081203719f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a49fb892a93344f393c58081203719f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a49fb892a93344f393c58081203719f7"}}, "title": "Mass gathering events and undetected transmission of SARS-CoV-2 in vulnerable populations leading to an outbreak with high case fatality ratio in the district of Tirschenreuth, Germany.", "authors": [{"family": "Brandl", "given": "M", "initials": "M"}, {"family": "Selb", "given": "R", "initials": "R"}, {"family": "Seidl-Pillmeier", "given": "S", "initials": "S"}, {"family": "Marosevic", "given": "D", "initials": "D"}, {"family": "Buchholz", "given": "U", "initials": "U"}, {"family": "Rehmet", "given": "S", "initials": "S"}], "type": "journal article", "published": "2020-10-13", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": "148", "issue": null, "pages": "e252", "issn-l": null}, "abstract": "In early March 2020, a COVID-19-outbreak occurred in the district of Tirschenreuth, Germany. The outbreak was characterised by a rapid increase in case numbers and a comparatively high crude case fatality ratio (CFR; 11%). Until the beginning of May 2020, 1122 cases were reported in the district. To investigate the outbreak, we analysed surveillance and other data available at the district health department, including data on cases living in care facilities and public health measures applied. Furthermore, we compared the number of tests performed in Tirschenreuth and in Germany as a whole. We interviewed the first 110 cases in order to investigate potential exposures at the beginning of the outbreak. We found that returning ski-travellers from Austria and Italy and early undetected community transmission likely initiated the outbreak which was then accelerated by Bavarian beer festivities. Testing of mainly acute cases in the district of Tirschenreuth resulted in a higher rate of positive tests compared to the whole of Germany. Despite adjustment for age, the CFR continued to exceed the German mean which was due to spread to vulnerable populations. Strict public health measures likely contributed to control the outbreak by mid-April 2020.", "doi": "10.1017/S0950268820002460", "pmid": "33046173", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0950268820002460"}, {"db": "pmc", "key": "PMC7588716"}], "notes": [], "created": "2020-12-01T17:14:59.942Z", "modified": "2021-02-26T08:45:48.542Z"}, {"entity": "publication", "iuid": "c349b903a6a94f64b50936430c06a8d2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c349b903a6a94f64b50936430c06a8d2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c349b903a6a94f64b50936430c06a8d2"}}, "title": "Influenza Vaccination to Reduce Cardiovascular Morbidity and Mortality in Patients With COVID-19: JACC State-of-the-Art Review.", "authors": [{"family": "Behrouzi", "given": "Bahar", "initials": "B"}, {"family": "Araujo Campoverde", "given": "Maria Viviana", "initials": "MV"}, {"family": "Liang", "given": "Kyle", "initials": "K"}, {"family": "Talbot", "given": "H Keipp", "initials": "HK"}, {"family": "Bogoch", "given": "Isaac I", "initials": "II"}, {"family": "McGeer", "given": "Allison", "initials": "A"}, {"family": "Fr\u00f6bert", "given": "Ole", "initials": "O"}, {"family": "Loeb", "given": "Mark", "initials": "M"}, {"family": "Vardeny", "given": "Orly", "initials": "O"}, {"family": "Solomon", "given": "Scott D", "initials": "SD"}, {"family": "Udell", "given": "Jacob A", "initials": "JA"}], "type": "journal article", "published": "2020-10-13", "journal": {"title": "J Am Coll Cardiol", "issn": "1558-3597", "volume": "76", "issue": "15", "pages": "1777-1794", "issn-l": "0735-1097"}, "abstract": "Viral respiratory infections are risk factors for cardiovascular disease (CVD). Underlying CVD is also associated with an increased risk of complications following viral respiratory infections, including increased morbidity, mortality, and health care utilization. Globally, these phenomena are observed with seasonal influenza and with the current coronavirus disease 2019 (COVID-19) pandemic. Persons with CVD represent an important target population for respiratory virus vaccines, with capacity developed within 3 large ongoing influenza vaccine cardiovascular outcomes trials to determine the potential cardioprotective effects of influenza vaccines. In the context of COVID-19, these international trial networks may be uniquely positioned to redeploy infrastructure to study therapies for primary and secondary prevention of COVID-19. Here, we describe mechanistic links between influenza and COVID-19 infection and the risk of acute cardiovascular events, summarize the data to date on the potential cardioprotective effects of influenza vaccines, and describe the ongoing influenza vaccine cardiovascular outcomes trials, highlighting important lessons learned that are applicable to COVID-19.", "doi": "10.1016/j.jacc.2020.08.028", "pmid": "33032740", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0735-1097(20)36325-7"}, {"db": "pmc", "key": "PMC7535809"}], "notes": [], "created": "2020-11-27T12:38:57.742Z", "modified": "2020-11-27T12:38:57.764Z"}, {"entity": "publication", "iuid": "f71ffb963b69438bbc97e6ec3b99934a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f71ffb963b69438bbc97e6ec3b99934a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f71ffb963b69438bbc97e6ec3b99934a"}}, "title": "The Impact of the COVID-19 Pandemic on Surgical Management of Breast Cancer: Global Trends and Future Perspectives.", "authors": [{"family": "Rocco", "given": "Nicola", "initials": "N"}, {"family": "Montagna", "given": "Giacomo", "initials": "G"}, {"family": "Di Micco", "given": "Rosa", "initials": "R"}, {"family": "Benson", "given": "John", "initials": "J"}, {"family": "Criscitiello", "given": "Carmen", "initials": "C"}, {"family": "Chen", "given": "Li", "initials": "L"}, {"family": "Di Pace", "given": "Bruno", "initials": "B"}, {"family": "Esgueva Colmenarejo", "given": "Antonio Jesus", "initials": "AJ"}, {"family": "Harder", "given": "Yves", "initials": "Y"}, {"family": "Karakatsanis", "given": "Andreas", "initials": "A"}, {"family": "Maglia", "given": "Anna", "initials": "A"}, {"family": "Mele", "given": "Marco", "initials": "M"}, {"family": "Nafissi", "given": "Nahid", "initials": "N"}, {"family": "Ferreira", "given": "Pedro Santos", "initials": "PS"}, {"family": "Taher", "given": "Wafa", "initials": "W"}, {"family": "Tejerina", "given": "Antonio", "initials": "A"}, {"family": "Vinci", "given": "Alessio", "initials": "A"}, {"family": "Nava", "given": "Maurizio", "initials": "M"}, {"family": "Catanuto", "given": "Giuseppe", "initials": "G"}], "type": "journal article", "published": "2020-10-12", "journal": {"title": "Oncologist", "issn": "1549-490X", "volume": "26", "issue": "1", "pages": "e66-e77", "issn-l": null}, "abstract": "The rapid spread of COVID-19 across the globe is forcing surgical oncologists to change their daily practice. We sought to evaluate how breast surgeons are adapting their surgical activity to limit viral spread and spare hospital resources.\n\nA panel of 12 breast surgeons from the most affected regions of the world convened a virtual meeting on April 7, 2020, to discuss the changes in their local surgical practice during the COVID-19 pandemic. Similarly, a Web-based poll based was created to evaluate changes in surgical practice among breast surgeons from several countries.\n\nThe virtual meeting showed that distinct countries and regions were experiencing different phases of the pandemic. Surgical priority was given to patients with aggressive disease not candidate for primary systemic therapy, those with progressive disease under neoadjuvant systemic therapy, and patients who have finished neoadjuvant therapy. One hundred breast surgeons filled out the poll. The trend showed reductions in operating room schedules, indications for surgery, and consultations, with an increasingly restrictive approach to elective surgery with worsening of the pandemic.\n\nThe COVID-19 emergency should not compromise treatment of a potentially lethal disease such as breast cancer. Our results reveal that physicians are instinctively reluctant to abandon conventional standards of care when possible. However, as the situation deteriorates, alternative strategies of de-escalation are being adopted.\n\nThis study aimed to characterize how the COVID-19 pandemic is affecting breast cancer surgery and which strategies are being adopted to cope with the situation.", "doi": "10.1002/onco.13560", "pmid": "33044007", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7675306"}], "notes": [], "created": "2020-12-01T17:18:02.032Z", "modified": "2021-02-26T08:45:48.873Z"}, {"entity": "publication", "iuid": "3ea73e2997424ea4a5071572466b1f6f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ea73e2997424ea4a5071572466b1f6f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ea73e2997424ea4a5071572466b1f6f"}}, "title": "Cardiac Troponin Testing in Patients with COVID-19: A Strategy for Testing and Reporting Results.", "authors": [{"family": "Kavsak", "given": "Peter A", "initials": "PA"}, {"family": "Hammarsten", "given": "Ola", "initials": "O"}, {"family": "Worster", "given": "Andrew", "initials": "A"}, {"family": "Smith", "given": "Stephen W", "initials": "SW"}, {"family": "Apple", "given": "Fred S", "initials": "FS"}], "type": "journal article", "published": "2020-10-12", "journal": {"title": "Clin Chem", "issn": "1530-8561", "volume": "67", "issue": "1", "pages": "107-113", "issn-l": "0009-9147"}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged late in 2019 causing COVID-19 (coronavirus disease-2019) may adversely affect the cardiovascular system. Publications from Asia, Europe and North America have identified cardiac troponin as an important prognostic indicator for patients hospitalized with COVID-19. We recognized from publications within the first 6 months of the pandemic that there has been much uncertainty on the reporting, interpretation, and pathophysiology of an increased cardiac troponin concentration in this setting.\n\nThe purpose of this mini-review is: a) to review the pathophysiology of SARS-CoV-2 and the cardiovascular system, b) to overview the strengths and weaknesses of selected studies evaluating cardiac troponin in patients with COVID-19, and c) recommend testing strategies in the acute period, in the convalescence period and in long-term care for patients who have become ill with COVID-19.\n\nThis review provides important educational information and identifies gaps in understanding the role of cardiac troponin and COVID-19. Future, properly designed studies will hopefully provide the much-needed evidence on the path forward in testing cardiac troponin in patients with COVID-19.", "doi": "10.1093/clinchem/hvaa225", "pmid": "33045044", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "5921202"}, {"db": "pmc", "key": "PMC7665403"}], "notes": [], "created": "2020-11-27T12:38:56.488Z", "modified": "2021-01-22T09:27:06.802Z"}, {"entity": "publication", "iuid": "80775a0ee6f946ec9ea6ffe6c38eda01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/80775a0ee6f946ec9ea6ffe6c38eda01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/80775a0ee6f946ec9ea6ffe6c38eda01"}}, "title": "Minor covid-19 association with crime in Sweden.", "authors": [{"family": "Gerell", "given": "Manne", "initials": "M"}, {"family": "Kardell", "given": "Johan", "initials": "J"}, {"family": "Kindgren", "given": "Johanna", "initials": "J"}], "type": "journal article", "published": "2020-10-11", "journal": {"title": "Crime Sci", "issn": "2193-7680", "issn-l": null, "volume": "9", "issue": "1", "pages": "19"}, "abstract": "The covid-19 disease has a large impact on life across the globe, and this could potentially include impacts on crime. The present study describes how crime has changed in Sweden during ten weeks after the government started to implement interventions to reduce spread of the disease. Sweden has undertaken smaller interventions than many other countries and is therefore a particularly interesting case to study. The first major interventions in Sweden were implemented in the end of week 11 (March 12th) in the year 2020, and we analyze police reported crimes through week 21 (ending May 24th). Descriptive statistics are provided relative to expected levels with 95% confidence intervals for eight crime types. We find that total crime, assaults, pickpocketing and burglary have decreased significantly, personal robberies and narcotics crime are unchanged. Vandalism possibly increased somewhat but is hard to draw any firm conclusions on. The reductions are fairly small for most crime types, in the 5-20% range, with pickpocketing being the biggest exception noting a 59% drop relative to expected levels.", "doi": "10.1186/s40163-020-00128-3", "pmid": "33072489", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "128"}, {"db": "pmc", "key": "PMC7548025"}], "notes": [], "created": "2020-12-01T17:03:37.772Z", "modified": "2022-11-09T08:56:13.634Z"}, {"entity": "publication", "iuid": "82fea9198e95441299581781787cd5e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82fea9198e95441299581781787cd5e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82fea9198e95441299581781787cd5e8"}}, "title": "May Mangafodipir or Other SOD Mimetics Contribute to Better Care in COVID-19 Patients?", "authors": [{"family": "Karlsson", "given": "Jan Olof G", "initials": "JOG"}, {"family": "Jynge", "given": "Per", "initials": "P"}, {"family": "Ignarro", "given": "Louis J", "initials": "LJ"}], "type": "journal article", "published": "2020-10-10", "journal": {"title": "Antioxidants (Basel)", "issn": "2076-3921", "issn-l": "2076-3921", "volume": "9", "issue": "10", "pages": null}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by massive inflammation of the arterial endothelium accompanied by vasoconstriction and widespread pulmonary micro thrombi. As a result, due to the destruction of nitric oxide ( \u2022NO) by inflammatory superoxide (O2\u2022-), pulmonary \u2022NO concentration ceases, resulting in uncontrolled platelet aggregation and massive thrombosis, which kills the patients. Introducing \u2022NO by inhalation (INO) may replace the loss of endothelium-derived \u2022NO. The first results from clinical trials with INO in SARS-CoV-2 patients show a rapid and sustained improvement in cardiopulmonary function and decreased inflammation. An ongoing phase III study is expected to confirm the method's efficacy. INO may hence become a first line treatment in SARS-CoV-2 patients. However, due to the rapid inactivation of \u2022NO by deoxyhemoglobin to nitrate, pulmonary administration of \u2022NO will not protect remote organs. Another INO-related pharmacological approach to protect SARS-CoV-2 patients from developing life-threatening disease is to inhibit the O2\u2022--driven destruction of \u2022NO by neutralizing inflammatory O2\u2022-. By making use of low molecular weight compounds that mimic the action of the enzyme manganese superoxide dismutase (MnSOD). The MnSOD mimetics of the so-called porphyrin type (e.g., AEOL 10150), salen type (e.g., EUK-8) and cyclic polyamine type (e.g., M40419, today known as GC4419 and avasopasem manganese) have all been shown to positively affect the inflammatory response in lung epithelial cells in preclinical models of chronic obstructive pulmonary disease. The Manganese diPyridoxyL EthylDiamine (MnPLED)-type mangafodipir (manganese dipyridoxyl diphosphate-MnDPDP), a magnetic resonance imaging (MRI) contrast agent that possesses MnSOD mimetic activity, has shown promising results in various forms of inflammation, in preclinical as well as clinical settings. Intravenously administration of mangafodipir will, in contrast to INO, reach remote organs and may hence become an important supplement to INO. From the authors' viewpoint, it appears logical to test mangafodipr in COVID-19 patients at risk of developing life-threatening SARS-CoV-2. Five days after submission of the current manuscript, Galera Pharmaceuticals Inc. announced the dosing of the first patient in a randomized, double-blind pilot phase II clinical trial with GC4419 for COVID-19. The study was first posted on ClinicalTrials.gov (Identifier: NCT04555096) 18 September 2020.", "doi": "10.3390/antiox9100971", "pmid": "33050459", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "antiox9100971"}, {"db": "pmc", "key": "PMC7601469"}, {"db": "ClinicalTrials.gov", "key": "NCT04555096"}], "notes": [], "created": "2020-11-27T10:48:45.935Z", "modified": "2022-11-09T08:57:17.902Z"}, {"entity": "publication", "iuid": "ee9bb534c987464f94919f14262a802b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee9bb534c987464f94919f14262a802b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee9bb534c987464f94919f14262a802b"}}, "title": "A prediction model to prioritize individuals for SARS-CoV-2 test built from national symptom surveys.", "authors": [{"family": "Shoer", "given": "Saar", "initials": "S"}, {"family": "Karady", "given": "Tal", "initials": "T"}, {"family": "Keshet", "given": "Ayya", "initials": "A"}, {"family": "Shilo", "given": "Smadar", "initials": "S"}, {"family": "Rossman", "given": "Hagai", "initials": "H"}, {"family": "Gavrieli", "given": "Amir", "initials": "A"}, {"family": "Meir", "given": "Tomer", "initials": "T"}, {"family": "Lavon", "given": "Amit", "initials": "A"}, {"family": "Kolobkov", "given": "Dmitry", "initials": "D"}, {"family": "Kalka", "given": "Iris", "initials": "I"}, {"family": "Godneva", "given": "Anastasia", "initials": "A"}, {"family": "Cohen", "given": "Ori", "initials": "O"}, {"family": "Kariv", "given": "Adam", "initials": "A"}, {"family": "Hoch", "given": "Ori", "initials": "O"}, {"family": "Zer-Aviv", "given": "Mushon", "initials": "M"}, {"family": "Castel", "given": "Noam", "initials": "N"}, {"family": "Sudre", "given": "Carole", "initials": "C"}, {"family": "Zohar", "given": "Anat Ekka", "initials": "AE"}, {"family": "Irony", "given": "Angela", "initials": "A"}, {"family": "Spector", "given": "Tim", "initials": "T"}, {"family": "Geiger", "given": "Benjamin", "initials": "B"}, {"family": "Hizi", "given": "Dorit", "initials": "D"}, {"family": "Shalev", "given": "Varda", "initials": "V"}, {"family": "Balicer", "given": "Ran", "initials": "R"}, {"family": "Segal", "given": "Eran", "initials": "E"}], "type": "journal article", "published": "2020-10-10", "journal": {"title": "Med (N Y)", "issn": "2666-6340", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The gold standard for COVID-19 diagnosis is detection of viral RNA through PCR. Due to global limitations in testing capacity, effective prioritization of individuals for testing is essential.\r\n\r\nWe devised a model estimating the probability of an individual to test positive for COVID-19 based on answers to 9 simple questions that have been associated with COVID-19 infection. Our model was devised from a subsample of a national symptom survey that was answered over 2 million times in Israel in its first 2 months and a targeted survey distributed to all residents of several cities in Israel. Overall, 43,752 adults were included, from which 498 self-reported as being COVID-19 positive.\r\n\r\nOur model was validated on a held-out set of individuals from Israel where it achieved an auROC of 0.737 (CI: 0.712-0.759), auPR of 0.144 (CI: 0.119-0.177) and demonstrated its applicability outside of Israel in an independently-collected symptom survey dataset from the U.S., U.K. and Sweden.Our analyses revealed interactions between several symptoms and age, suggesting variation in the clinical manifestation of the disease in different age groups.\r\n\r\nour tool can be used online and without exposure to suspected patients, thus suggesting worldwide utility in combating COVID-19 by better directing the limited testing resources through prioritization of individuals for testing, thereby increasing the rate at which positive individuals can be identified. Moreover, individuals at high risk for a positive test result can be isolated prior to testing.", "doi": "10.1016/j.medj.2020.10.002", "pmid": "33073258", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-6340(20)30019-2"}, {"db": "pmc", "key": "PMC7547576"}], "notes": [], "created": "2020-11-27T11:50:21.127Z", "modified": "2022-11-09T08:58:28.888Z"}, {"entity": "publication", "iuid": "bb9e41d5e6b0498f97833c6922ab9c73", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb9e41d5e6b0498f97833c6922ab9c73.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb9e41d5e6b0498f97833c6922ab9c73"}}, "title": "More Than Smell-COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis.", "authors": [{"family": "Parma", "given": "Valentina", "initials": "V"}, {"family": "Ohla", "given": "Kathrin", "initials": "K"}, {"family": "Veldhuizen", "given": "Maria G", "initials": "MG"}, {"family": "Niv", "given": "Masha Y", "initials": "MY"}, {"family": "Kelly", "given": "Christine E", "initials": "CE"}, {"family": "Bakke", "given": "Alyssa J", "initials": "AJ"}, {"family": "Cooper", "given": "Keiland W", "initials": "KW"}, {"family": "Bouysset", "given": "C\u00e9dric", "initials": "C"}, {"family": "Pirastu", "given": "Nicola", "initials": "N"}, {"family": "Dibattista", "given": "Michele", "initials": "M"}, {"family": "Kaur", "given": "Rishemjit", "initials": "R"}, {"family": "Liuzza", "given": "Marco Tullio", "initials": "MT"}, {"family": "Pepino", "given": "Marta Y", "initials": "MY"}, {"family": "Sch\u00f6pf", "given": "Veronika", "initials": "V"}, {"family": "Pereda-Loth", "given": "Veronica", "initials": "V"}, {"family": "Olsson", "given": "Shannon B", "initials": "SB"}, {"family": "Gerkin", "given": "Richard C", "initials": "RC"}, {"family": "Rohlfs Dom\u00ednguez", "given": "Paloma", "initials": "P"}, {"family": "Albayay", "given": "Javier", "initials": "J"}, {"family": "Farruggia", "given": "Michael C", "initials": "MC"}, {"family": "Bhutani", "given": "Surabhi", "initials": "S"}, {"family": "Fjaeldstad", "given": "Alexander W", "initials": "AW"}, {"family": "Kumar", "given": "Ritesh", "initials": "R"}, {"family": "Menini", "given": "Anna", "initials": "A"}, {"family": "Bensafi", "given": "Moustafa", "initials": "M"}, {"family": "Sandell", "given": "Mari", "initials": "M"}, {"family": "Konstantinidis", "given": "Iordanis", "initials": "I"}, {"family": "Di Pizio", "given": "Antonella", "initials": "A"}, {"family": "Genovese", "given": "Federica", "initials": "F"}, {"family": "\u00d6zt\u00fcrk", "given": "Lina", "initials": "L"}, {"family": "Thomas-Danguin", "given": "Thierry", "initials": "T"}, {"family": "Frasnelli", "given": "Johannes", "initials": "J"}, {"family": "Boesveldt", "given": "Sanne", "initials": "S"}, {"family": "Saatci", "given": "\u00d6zlem", "initials": "\u00d6"}, {"family": "Saraiva", "given": "Luis R", "initials": "LR"}, {"family": "Lin", "given": "Cailu", "initials": "C"}, {"family": "Golebiowski", "given": "J\u00e9r\u00f4me", "initials": "J"}, {"family": "Hwang", "given": "Liang-Dar", "initials": "L"}, {"family": "Ozdener", "given": "Mehmet Hakan", "initials": "MH"}, {"family": "Gu\u00e0rdia", "given": "Maria Dolors", "initials": "MD"}, {"family": "Laudamiel", "given": "Christophe", "initials": "C"}, {"family": "Ritchie", "given": "Marina", "initials": "M"}, {"family": "Havl\u00edcek", "given": "Jan", "initials": "J"}, {"family": "Pierron", "given": "Denis", "initials": "D"}, {"family": "Roura", "given": "Eugeni", "initials": "E"}, {"family": "Navarro", "given": "Marta", "initials": "M"}, {"family": "Nolden", "given": "Alissa A", "initials": "AA"}, {"family": "Lim", "given": "Juyun", "initials": "J"}, {"family": "Whitcroft", "given": "Katherine L", "initials": "KL"}, {"family": "Colquitt", "given": "Lauren R", "initials": "LR"}, {"family": "Ferdenzi", "given": "Camille", "initials": "C"}, {"family": "Brindha", "given": "Evelyn V", "initials": "EV"}, {"family": "Altundag", "given": "Aytug", "initials": "A"}, {"family": "Macchi", "given": "Alberto", "initials": "A"}, {"family": "Nunez-Parra", "given": "Alexia", "initials": "A"}, {"family": "Patel", "given": "Zara M", "initials": "ZM"}, {"family": "Fiorucci", "given": "S\u00e9bastien", "initials": "S"}, {"family": "Philpott", "given": "Carl M", "initials": "CM"}, {"family": "Smith", "given": "Barry C", "initials": "BC"}, {"family": "Lundstr\u00f6m", "given": "Johan N", "initials": "JN"}, {"family": "Mucignat", "given": "Carla", "initials": "C"}, {"family": "Parker", "given": "Jane K", "initials": "JK"}, {"family": "van den Brink", "given": "Mirjam", "initials": "M"}, {"family": "Schmuker", "given": "Michael", "initials": "M"}, {"family": "Fischmeister", "given": "Florian Ph S", "initials": "FPS"}, {"family": "Heinbockel", "given": "Thomas", "initials": "T"}, {"family": "Shields", "given": "Vonnie D C", "initials": "VDC"}, {"family": "Faraji", "given": "Farhoud", "initials": "F"}, {"family": "Santamar\u00eda", "given": "Enrique", "initials": "E"}, {"family": "Fredborg", "given": "William E A", "initials": "WEA"}, {"family": "Morini", "given": "Gabriella", "initials": "G"}, {"family": "Olofsson", "given": "Jonas K", "initials": "JK"}, {"family": "Jalessi", "given": "Maryam", "initials": "M"}, {"family": "Karni", "given": "Noam", "initials": "N"}, {"family": "D'Errico", "given": "Anna", "initials": "A"}, {"family": "Alizadeh", "given": "Rafieh", "initials": "R"}, {"family": "Pellegrino", "given": "Robert", "initials": "R"}, {"family": "Meyer", "given": "Pablo", "initials": "P"}, {"family": "Huart", "given": "Caroline", "initials": "C"}, {"family": "Chen", "given": "Ben", "initials": "B"}, {"family": "Soler", "given": "Graciela M", "initials": "GM"}, {"family": "Alwashahi", "given": "Mohammed K", "initials": "MK"}, {"family": "Welge-L\u00fcssen", "given": "Antje", "initials": "A"}, {"family": "Freiherr", "given": "Jessica", "initials": "J"}, {"family": "de Groot", "given": "Jasper H B", "initials": "JHB"}, {"family": "Klein", "given": "Hadar", "initials": "H"}, {"family": "Okamoto", "given": "Masako", "initials": "M"}, {"family": "Singh", "given": "Preet Bano", "initials": "PB"}, {"family": "Hsieh", "given": "Julien W", "initials": "JW"}, {"family": "GCCR Group Author", "given": "", "initials": ""}, {"family": "Reed", "given": "Danielle R", "initials": "DR"}, {"family": "Hummel", "given": "Thomas", "initials": "T"}, {"family": "Munger", "given": "Steven D", "initials": "SD"}, {"family": "Hayes", "given": "John E", "initials": "JE"}], "type": "journal article", "published": "2020-10-09", "journal": {"title": "Chem Senses", "issn": "1464-3553", "issn-l": "0379-864X", "volume": "45", "issue": "7", "pages": "609-622"}, "abstract": "Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change \u00b1100) revealed a mean reduction of smell (-79.7 \u00b1 28.7, mean \u00b1 standard deviation), taste (-69.0 \u00b1 32.6), and chemesthetic (-37.3 \u00b1 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.", "doi": "10.1093/chemse/bjaa041", "pmid": "32564071", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "5860460"}, {"db": "pmc", "key": "PMC7337664"}], "notes": [], "created": "2020-12-08T16:36:10.943Z", "modified": "2021-06-17T08:27:50.863Z"}, {"entity": "publication", "iuid": "b0f0deb544914e6da3b55eb7fa321c80", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b0f0deb544914e6da3b55eb7fa321c80.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b0f0deb544914e6da3b55eb7fa321c80"}}, "title": "Beyond COVID-19-a paradigm shift in infection management?", "authors": [{"family": "Vehreschild", "given": "Maria J G T", "initials": "MJGT"}, {"family": "Tacconelli", "given": "Evelina", "initials": "E"}, {"family": "Giske", "given": "Christian G", "initials": "CG"}, {"family": "Peschel", "given": "Andreas", "initials": "A"}], "type": "letter", "published": "2020-10-09", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/S1473-3099(20)30789-1", "pmid": "33045187", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(20)30789-1"}, {"db": "pmc", "key": "PMC7546645"}], "notes": [], "created": "2020-12-01T17:16:03.841Z", "modified": "2020-12-01T17:16:03.868Z"}, {"entity": "publication", "iuid": "4f2ba3380aa140688274e008ceb51960", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4f2ba3380aa140688274e008ceb51960.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4f2ba3380aa140688274e008ceb51960"}}, "title": "A population-based cohort study of socio-demographic risk factors for COVID-19 deaths in Sweden.", "authors": [{"family": "Drefahl", "given": "Sven", "initials": "S"}, {"family": "Wallace", "given": "Matthew", "initials": "M"}, {"family": "Mussino", "given": "Eleonora", "initials": "E"}, {"family": "Aradhya", "given": "Siddartha", "initials": "S"}, {"family": "Kolk", "given": "Martin", "initials": "M"}, {"family": "Brand\u00e9n", "given": "Maria", "initials": "M"}, {"family": "Malmberg", "given": "Bo", "initials": "B"}, {"family": "Andersson", "given": "Gunnar", "initials": "G"}], "type": "journal article", "published": "2020-10-09", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "11", "issue": "1", "pages": "5097"}, "abstract": "As global deaths from COVID-19 continue to rise, the world's governments, institutions, and agencies are still working toward an understanding of who is most at risk of death. In this study, data on all recorded COVID-19 deaths in Sweden up to May 7, 2020 are linked to high-quality and accurate individual-level background data from administrative registers of the total population. By means of individual-level survival analysis we demonstrate that being male, having less individual income, lower education, not being married all independently predict a higher risk of death from COVID-19 and from all other causes of death. Being an immigrant from a low- or middle-income country predicts higher risk of death from COVID-19 but not for all other causes of death. The main message of this work is that the interaction of the virus causing COVID-19 and its social environment exerts an unequal burden on the most disadvantaged members of society.", "doi": "10.1038/s41467-020-18926-3", "pmid": "33037218", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-020-18926-3"}, {"db": "pmc", "key": "PMC7547672"}], "notes": [], "created": "2020-12-01T17:25:48.061Z", "modified": "2022-11-09T08:59:59.030Z"}, {"entity": "publication", "iuid": "6b71d3289aed493a916aaaca1fbb2ea6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b71d3289aed493a916aaaca1fbb2ea6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b71d3289aed493a916aaaca1fbb2ea6"}}, "title": "What every Researcher should know about Searching - Clarified Concepts, Search Advice, and an Agenda to improve Finding in Academia.", "authors": [{"family": "Gusenbauer", "given": "Michael", "initials": "M"}, {"family": "Haddaway", "given": "Neal R", "initials": "NR"}], "type": "journal article", "published": "2020-10-08", "journal": {"title": "Res Synth Methods", "issn": "1759-2887", "volume": null, "issue": null, "issn-l": null}, "abstract": "We researchers have taken searching for information for granted for far too long. The COVID-19 pandemic shows us the boundaries of academic searching capabilities, both in terms of our know-how and of the systems we have. With hundreds of studies published daily on COVID-19, for example, we struggle to find, stay up-to-date, and synthesize information-all hampering evidence-informed decision making. This COVID-19 information crisis is indicative of the broader problem of information overloaded academic research. To improve our finding capabilities, we urgently need to improve how we search and the systems we use. We respond to Klopfenstein and Dampier (Res Syn Meth. 2020) who commented on our 2020 paper and proposed a way of improving PubMed's and Google Scholar's search functionalities. Our response puts their commentary in a larger frame and suggests how we can improve academic searching altogether. We urge that researchers need to understand that search skills require dedicated education and training. Better and more efficient searching requires an initial understanding of the different goals that define the way searching needs to be conducted. We explain the main types of searching that we academics routinely engage in; distinguishing lookup, exploratory, and systematic searching. These three types must be conducted using different search methods (heuristics) and using search systems with specific capabilities. To improve academic searching, we introduce the \"Search Triangle\" model emphasizing the importance of matching goals, heuristics, and systems. Further, we suggest an urgently needed agenda toward search literacy as the norm in academic research and fit-for-purpose search systems.", "doi": "10.1002/jrsm.1457", "pmid": "33031639", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-01T17:31:05.757Z", "modified": "2020-12-01T17:31:05.783Z"}, {"entity": "publication", "iuid": "d94e32a234a0498cbac9b9f2af96a362", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d94e32a234a0498cbac9b9f2af96a362.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d94e32a234a0498cbac9b9f2af96a362"}}, "title": "SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden.", "authors": [{"family": "Rudberg", "given": "Ann-Sofie", "initials": "AS", "orcid": "0000-0003-3616-9943", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7acfc6023c44aa2a878fbacc3dba7fb.json"}}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c735ef404391493980e4e51d70459ce0.json"}}, {"family": "Jernbom Falk", "given": "August", "initials": "A", "orcid": "0000-0002-7773-1851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40d944d7fa964f4292f10012356a2730.json"}}, {"family": "Aguilera", "given": "Katherina", "initials": "K"}, {"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/305bca9e5c6c423898c272bf06ce2f2a.json"}}, {"family": "Gabrielsson", "given": "Lena", "initials": "L"}, {"family": "Salomonsson", "given": "Ann-Christin", "initials": "AC"}, {"family": "Hanke", "given": "Leo", "initials": "L", "orcid": "0000-0001-5514-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a35f10de4f2e4aee98278f6ab845613d.json"}}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "McInerney", "given": "Gerald", "initials": "G", "orcid": "0000-0003-2257-7241", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7770437d845444a8a07865bf5b62fab0.json"}}, {"family": "Olofsson", "given": "Jennie", "initials": "J"}, {"family": "Andersson", "given": "Eni", "initials": "E", "orcid": "0000-0002-5115-0637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8200b399e954f3482aec53a62df3b54.json"}}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C", "orcid": "0000-0003-0880-5375", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7394cf1c96945888fc8765568f5407c.json"}}, {"family": "Bayati", "given": "Shaghayegh", "initials": "S"}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Sj\u00f6berg", "given": "Ronald", "initials": "R"}, {"family": "Tegel", "given": "Hanna", "initials": "H"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1345-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a53a433db6f04a458e3d420f0c9995c5.json"}}], "type": "journal article", "published": "2020-10-08", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "11", "issue": "1", "pages": "5064"}, "abstract": "SARS-CoV-2 may pose an occupational health risk to healthcare workers. Here, we report the seroprevalence of SARS-CoV-2 antibodies, self-reported symptoms and occupational exposure to SARS-CoV-2 among healthcare workers at a large acute care hospital in Sweden. The seroprevalence of IgG antibodies against SARS-CoV-2 was 19.1% among the 2149 healthcare workers recruited between April 14th and May 8th 2020, which was higher than the reported regional seroprevalence during the same time period. Symptoms associated with seroprevalence were anosmia (odds ratio (OR) 28.4, 95% CI 20.6-39.5) and ageusia (OR 19.2, 95% CI 14.3-26.1). Seroprevalence was also associated with patient contact (OR 2.9, 95% CI 1.9-4.5) and covid-19 patient contact (OR 3.3, 95% CI 2.2-5.3). These findings imply an occupational risk for SARS-CoV-2 infection among healthcare workers. Continued measures are warranted to assure healthcare workers safety and reduce transmission from healthcare workers to patients and to the community.", "doi": "10.1038/s41467-020-18848-0", "pmid": "33033249", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Funder: H2020": null, "Category: Health": null, "Category: Serology": null}, "xrefs": [{"db": "pmc", "key": "PMC7544689"}, {"db": "pii", "key": "10.1038/s41467-020-18848-0"}], "notes": [], "created": "2020-10-30T11:46:40.143Z", "modified": "2023-06-19T14:24:22.660Z"}, {"entity": "publication", "iuid": "7c590b4e9a234f918c74726c082da341", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7c590b4e9a234f918c74726c082da341.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7c590b4e9a234f918c74726c082da341"}}, "title": "Living with the COVID-19 pandemic: act now with the tools we have.", "authors": [{"family": "Bedford", "given": "Juliet", "initials": "J"}, {"family": "Enria", "given": "Delia", "initials": "D"}, {"family": "Giesecke", "given": "Johan", "initials": "J"}, {"family": "Heymann", "given": "David L", "initials": "DL"}, {"family": "Ihekweazu", "given": "Chikwe", "initials": "C"}, {"family": "Kobinger", "given": "Gary", "initials": "G"}, {"family": "Lane", "given": "H Clifford", "initials": "HC"}, {"family": "Memish", "given": "Ziad A", "initials": "ZA"}, {"family": "Oh", "given": "Myoung-Don", "initials": "MD"}, {"family": "Sall", "given": "Amadou Alpha", "initials": "AA"}, {"family": "Ungchusak", "given": "Kumnuan", "initials": "K"}, {"family": "Wieler", "given": "Lothar H", "initials": "LH"}, {"family": "WHO Strategic and Technical Advisory Group for Infectious Hazards", "given": "", "initials": ""}], "type": "journal article", "published": "2020-10-08", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": null, "issue": null, "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)32117-6", "pmid": "33038947", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)32117-6"}, {"db": "pmc", "key": "PMC7544497"}], "notes": [], "created": "2020-12-01T17:21:13.505Z", "modified": "2020-12-01T17:21:13.515Z"}, {"entity": "publication", "iuid": "64e939415762403c9009f86ec14f76ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/64e939415762403c9009f86ec14f76ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/64e939415762403c9009f86ec14f76ef"}}, "title": "Intravenous immunoglobulin therapy in COVID-19-related encephalopathy.", "authors": [{"family": "Muccioli", "given": "Lorenzo", "initials": "L"}, {"family": "Pensato", "given": "Umberto", "initials": "U"}, {"family": "Bernab\u00e8", "given": "Giorgia", "initials": "G"}, {"family": "Ferri", "given": "Lorenzo", "initials": "L"}, {"family": "Tappat\u00e0", "given": "Maria", "initials": "M"}, {"family": "Volpi", "given": "Lilia", "initials": "L"}, {"family": "Cani", "given": "Ilaria", "initials": "I"}, {"family": "Henry", "given": "Olivia J", "initials": "OJ"}, {"family": "Ceccaroni", "given": "Francesca", "initials": "F"}, {"family": "Cevoli", "given": "Sabina", "initials": "S"}, {"family": "Stofella", "given": "Gloria", "initials": "G"}, {"family": "Pasini", "given": "Elena", "initials": "E"}, {"family": "Fornaro", "given": "Giacomo", "initials": "G"}, {"family": "Tonon", "given": "Caterina", "initials": "C"}, {"family": "Vidale", "given": "Simone", "initials": "S"}, {"family": "Liguori", "given": "Rocco", "initials": "R"}, {"family": "Tinuper", "given": "Paolo", "initials": "P"}, {"family": "Michelucci", "given": "Roberto", "initials": "R"}, {"family": "Cortelli", "given": "Pietro", "initials": "P"}, {"family": "Bisulli", "given": "Francesca", "initials": "F"}], "type": "journal article", "published": "2020-10-08", "journal": {"title": "J Neurol", "issn": "1432-1459", "volume": null, "issue": null, "issn-l": null}, "abstract": "To report on efficacy and safety of intravenous immunoglobulin (IVIg) therapy in a case series of patients with COVID-19-related encephalopathy.\n\nWe retrospectively collected data on all patients with COVID-19 hospitalized at two Italian hospitals who developed encephalopathy during disease course and were treated with IVIg.\n\nFive patients (two females, mean age 66.8 years) developed encephalopathy after a mean of 12.6 days, since the onset of respiratory/constitutional symptoms related to COVID-19. Four patients suffered severe respiratory distress, three of which required invasive mechanical ventilation. Neurological manifestations included impaired consciousness, agitation, delirium, pyramidal and extrapyramidal signs. EEG demonstrated diffuse slowing in all patients. Brain MRI showed non-specific findings. CSF analysis revealed normal cell count and protein levels. In all subjects, RT-PCR for SARS-CoV-2 in CSF tested negative. IVIg at 0.4 g/kg/die was commenced 29.8 days (mean, range: 19-55 days) after encephalopathy onset, leading to complete electroclinical recovery in all patients, with an initial improvement of neuropsychiatric symptoms observed in 3.4 days (mean, range: 1-10 days). No adverse events related to IVIg were observed.\n\nOur preliminary findings suggest that IVIg may represent a safe and effective treatment for COVID-19-associated encephalopathy. Clinical efficacy may be driven by the anti-inflammatory action of IVIg, associated with its anti-cytokine qualities.", "doi": "10.1007/s00415-020-10248-0", "pmid": "33030607", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00415-020-10248-0"}, {"db": "pmc", "key": "PMC7543032"}], "notes": [], "created": "2020-12-01T17:32:59.107Z", "modified": "2021-02-26T08:45:48.261Z"}, {"entity": "publication", "iuid": "b327cae0f4e3414480b4ac802d8a4bd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b327cae0f4e3414480b4ac802d8a4bd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b327cae0f4e3414480b4ac802d8a4bd0"}}, "title": "Airborne spread of infectious SARS-CoV-2: Moving forward using lessons from SARS-CoV and MERS-CoV.", "authors": [{"family": "da Silva", "given": "Priscilla Gomes", "initials": "PG"}, {"family": "Nascimento", "given": "Maria S\u00e3o Jos\u00e9", "initials": "MSJ"}, {"family": "Soares", "given": "Ruben R G", "initials": "RRG"}, {"family": "Sousa", "given": "Sofia I V", "initials": "SIV"}, {"family": "Mesquita", "given": "Jo\u00e3o R", "initials": "JR"}], "type": "journal article", "published": "2020-10-08", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "volume": null, "issue": null, "pages": "142802", "issn-l": "0048-9697"}, "abstract": "Although an increasing body of data reports the detection of SARS-CoV-2 RNA in air, this does not correlate to the presence of infectious viruses, thus not evaluating the risk for airborne COVID-19. Hence there is a marked knowledge gap that requires urgent attention. Therefore, in this systematic review, viability/stability of airborne SARS-CoV-2, SARS-CoV and MERS-CoV viruses is discussed.\n\nA systematic literature review was performed on PubMed/MEDLINE, Web of Science and Scopus to assess the stability and viability of SARS-CoV, MERS-CoV and SARS-CoV-2 on air samples.\n\nThe initial search identified 27 articles. Following screening of titles and abstracts and removing duplicates, 11 articles were considered relevant. Temperatures ranging from 20 \u00b0C to 25 \u00b0C and relative humidity ranging from 40% to 50% were reported to have a protective effect on viral viability for airborne SARS-CoV and MERS-CoV. As no data is yet available on the conditions influencing viability for airborne SARS-CoV-2, and given the genetic similarity to SARS-CoV and MERS-CoV, one could extrapolate that the same conditions would apply. Nonetheless, the effect of these conditions seems to be residual considering the increasing number of cases in the south of USA, Brazil and India, where high temperatures and humidities have been observed.\n\nHigher temperatures and high relative humidity can have a modest effect on SARS-CoV-2 viability in the environment, as reported in previous studies to this date. However, these studies are experimental, and do not support the fact that the virus has efficiently spread in the tropical regions of the globe, with other transmission routes such as the contact and droplet ones probably being responsible for the majority of cases reported in these regions, along with other factors such as human mobility patterns and contact rates. Further studies are needed to investigate the extent of aerosol transmission of SARS-CoV-2 as this would have important implications for public health and infection-control policies.", "doi": "10.1016/j.scitotenv.2020.142802", "pmid": "33071145", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(20)36331-2"}, {"db": "pmc", "key": "PMC7543729"}], "notes": [], "created": "2020-11-27T11:51:35.091Z", "modified": "2020-12-01T17:05:19.632Z"}, {"entity": "publication", "iuid": "25657ae6d3c7476b9a979baf93ddb9f3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/25657ae6d3c7476b9a979baf93ddb9f3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/25657ae6d3c7476b9a979baf93ddb9f3"}}, "title": "Psychological distress among Iranian health-care providers exposed to coronavirus disease 2019 (COVID-19): a qualitative study.", "authors": [{"family": "Alizadeh", "given": "Azizeh", "initials": "A"}, {"family": "Khankeh", "given": "Hamid Reza", "initials": "HR"}, {"family": "Barati", "given": "Mohammad", "initials": "M"}, {"family": "Ahmadi", "given": "Yazdan", "initials": "Y"}, {"family": "Hadian", "given": "Arash", "initials": "A"}, {"family": "Azizi", "given": "Maryam", "initials": "M"}], "type": "journal article", "published": "2020-10-07", "journal": {"title": "BMC Psychiatry", "issn": "1471-244X", "issn-l": null, "volume": "20", "issue": "1", "pages": "494"}, "abstract": "Novel corona virus, named COVID-19, has spread rapidly to other countries like Italy, Iran and South Korea and affected all people, especially health-care providers. Therefore, due to the rapid spread of the disease in Iran, the aim of the present study was to explore psychological distress experienced by Iranian health-care providers in the first few weeks of the corona virus outbreak.\r\n\r\nThe present qualitative study was conducted on 18 Iranian health-care providers exposed to COVID - 19 using a content analysis method. Purposeful sampling was used to select the participants and continued until data saturation was reached. Data were collected using semi-structured interviews and then the qualitative data were analyzed through direct content analysis.\r\n\r\nBy analyzing 236 primary codes, two main categories were extracted from the experiences of health-care providers during corona virus outbreak. The first category included Occupational demands with three sub-categories: nature of illness, Organizational demands and social demands. The second category was Supportive resources included personal support and social support.\r\n\r\nThe results of this study found that there were some barriers and challenges to medical personnel exposed to COVID-19 that caused psychological distress. Some of these problems related to the nature of illness, others related to social and organizational demands and some of supportive resources buffer the relationship between occupational demands and psychological distress.", "doi": "10.1186/s12888-020-02889-2", "pmid": "33028290", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12888-020-02889-2"}, {"db": "pmc", "key": "PMC7538532"}], "notes": [], "created": "2020-12-03T08:51:27.977Z", "modified": "2022-11-09T09:00:38.111Z"}, {"entity": "publication", "iuid": "932740d940544f29a914b99552819522", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/932740d940544f29a914b99552819522.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/932740d940544f29a914b99552819522"}}, "title": "Were clinical routines for good end-of-life care maintained in hospitals and nursing homes during the first three months of the outbreak of COVID-19? A national register study.", "authors": [{"family": "Martinsson", "given": "Lisa", "initials": "L"}, {"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "Bergstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Staffan", "initials": "S"}], "type": "journal article", "published": "2020-10-06", "journal": {"title": "J Pain Symptom Manage", "issn": "1873-6513", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Although the COVID-19 pandemic might affect important clinical routines, few studies have focused on the maintenance of good quality in end-of-life care.\r\n\r\nThe objective was to examine whether adherence to clinical routines for good end-of-life care differed for deaths due to COVID-19 compared to a reference cohort from 2019, and whether they differed between nursing homes and hospitals.\r\n\r\nData about five items reflecting clinical routines for persons who died an expected death from COVID-19 during the first three months of the pandemic (March-May 2020) were collected from the Swedish Register of Palliative Care. The items were compared between the COVID-19 group and the reference cohort, and between the nursing home and hospital COVID-19 deaths.\r\n\r\n1316 expected deaths were identified in nursing homes and 685 in hospitals. Four of the five items differed for total COVID-19 group compared to the reference cohort: fewer were examined by a physician during the last days before death, pain and oral health were less likely to be assessed, and fewer had had a specialised palliative care team consultation (p < .0001, respectively). Assessment of symptoms other than pain did not differ significantly. The five items differed between the nursing homes and hospitals in the COVID-19 group, most notably regarding the proportion of persons examined by a physician during the last days (nursing homes - 18%, hospitals - 100%).\r\n\r\nThis national register study shows that several clinical routines for end-of-life care did not meet the usual standards during the first three months of the COVID-19 pandemic in Sweden. Higher preparedness for and monitoring of end-of-life care quality should be integrated into future pandemic plans.", "doi": "10.1016/j.jpainsymman.2020.09.043", "pmid": "33035649", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0885-3924(20)30794-6"}, {"db": "pmc", "key": "PMC7538392"}], "notes": [], "created": "2020-12-01T17:29:08.233Z", "modified": "2021-02-26T08:47:00.076Z"}, {"entity": "publication", "iuid": "5df1142a5d38410a8a9d94601249e1fe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5df1142a5d38410a8a9d94601249e1fe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5df1142a5d38410a8a9d94601249e1fe"}}, "title": "Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study.", "authors": [{"family": "Burn", "given": "Edward", "initials": "E"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Abedtash", "given": "Hamed", "initials": "H"}, {"family": "Abrah\u00e3o", "given": "Maria Tereza F", "initials": "MTF"}, {"family": "Alberga", "given": "Amanda", "initials": "A"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Aragon", "given": "Maria", "initials": "M"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Banda", "given": "Juan M", "initials": "JM"}, {"family": "Cho", "given": "Jaehyeong", "initials": "J"}, {"family": "Culhane", "given": "Aedin C", "initials": "AC"}, {"family": "Davydov", "given": "Alexander", "initials": "A"}, {"family": "DeFalco", "given": "Frank J", "initials": "FJ"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "DuVall", "given": "Scott", "initials": "S"}, {"family": "Falconer", "given": "Thomas", "initials": "T"}, {"family": "Fernandez-Bertolin", "given": "Sergio", "initials": "S"}, {"family": "Gao", "given": "Weihua", "initials": "W"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Hardin", "given": "Jill", "initials": "J"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Huser", "given": "Vojtech", "initials": "V"}, {"family": "Jeon", "given": "Hokyun", "initials": "H"}, {"family": "Jing", "given": "Yonghua", "initials": "Y"}, {"family": "Jung", "given": "Chi Young", "initials": "CY"}, {"family": "Kaas-Hansen", "given": "Benjamin Skov", "initials": "BS"}, {"family": "Kaduk", "given": "Denys", "initials": "D"}, {"family": "Kent", "given": "Seamus", "initials": "S"}, {"family": "Kim", "given": "Yeesuk", "initials": "Y"}, {"family": "Kolovos", "given": "Spyros", "initials": "S"}, {"family": "Lane", "given": "Jennifer C E", "initials": "JCE"}, {"family": "Lee", "given": "Hyejin", "initials": "H"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Makadia", "given": "Rupa", "initials": "R"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Mehta", "given": "Paras P", "initials": "PP"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Natarajan", "given": "Karthik", "initials": "K"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Park", "given": "Rae Woong", "initials": "RW"}, {"family": "Park", "given": "Jimyung", "initials": "J"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A"}, {"family": "Rao", "given": "Gowtham", "initials": "G"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Rho", "given": "Yeunsook", "initials": "Y"}, {"family": "Rijnbeek", "given": "Peter", "initials": "P"}, {"family": "Schilling", "given": "Lisa M", "initials": "LM"}, {"family": "Schuemie", "given": "Martijn", "initials": "M"}, {"family": "Shah", "given": "Nigam H", "initials": "NH"}, {"family": "Shoaibi", "given": "Azza", "initials": "A"}, {"family": "Song", "given": "Seokyoung", "initials": "S"}, {"family": "Spotnitz", "given": "Matthew", "initials": "M"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Swerdel", "given": "Joel N", "initials": "JN"}, {"family": "Vizcaya", "given": "David", "initials": "D"}, {"family": "Volpe", "given": "Salvatore", "initials": "S"}, {"family": "Wen", "given": "Haini", "initials": "H"}, {"family": "Williams", "given": "Andrew E", "initials": "AE"}, {"family": "Yimer", "given": "Belay B", "initials": "BB"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhuk", "given": "Oleg", "initials": "O"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}], "type": "journal article", "published": "2020-10-06", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "11", "issue": "1", "pages": "5009"}, "abstract": "Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. Here, we describe the characteristics of adults hospitalised with COVID-19 and compare them with influenza patients. We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) COVID-19 patients, summarising between 4811 and 11,643 unique aggregate characteristics. COVID-19 patients have been majority male in the US and Spain, but predominantly female in South Korea. Age profiles vary across data sources. Compared to 84,585 individuals hospitalised with influenza in 2014-19, COVID-19 patients have more typically been male, younger, and with fewer comorbidities and lower medication use. While protecting groups vulnerable to influenza is likely a useful starting point in the response to COVID-19, strategies will likely need to be broadened to reflect the particular characteristics of individuals being hospitalised with COVID-19.", "doi": "10.1038/s41467-020-18849-z", "pmid": "33024121", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-020-18849-z"}, {"db": "pmc", "key": "PMC7538555"}, {"db": "URL", "key": "http://evidence.ohdsi.org/Covid19CharacterizationHospitalization/.", "description": "http://evidence.ohdsi.org/Covid19CharacterizationHospitalization/."}, {"db": "URL", "key": "https://github.com/ohdsi-studies/Covid19HospitalizationCharacterization", "description": "https://github.com/ohdsi-studies/Covid19HospitalizationCharacterization"}], "notes": [], "created": "2020-11-27T12:39:00.134Z", "modified": "2023-01-13T09:49:38.516Z"}, {"entity": "publication", "iuid": "ec79c7a6fc0447b285f5e0f27b17d2ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec79c7a6fc0447b285f5e0f27b17d2ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec79c7a6fc0447b285f5e0f27b17d2ff"}}, "title": "Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2.", "authors": [{"family": "Rogstam", "given": "Annika", "initials": "A"}, {"family": "Nyblom", "given": "Maria", "initials": "M"}, {"family": "Christensen", "given": "Signe", "initials": "S"}, {"family": "Sele", "given": "Celeste", "initials": "C"}, {"family": "Talibov", "given": "Vladimir O", "initials": "VO"}, {"family": "Lindvall", "given": "Therese", "initials": "T"}, {"family": "Rasmussen", "given": "Anna Andersson", "initials": "AA"}, {"family": "Andr\u00e9", "given": "Ingemar", "initials": "I"}, {"family": "Fisher", "given": "Zo\u00eb", "initials": "Z"}, {"family": "Knecht", "given": "Wolfgang", "initials": "W"}, {"family": "Kozielski", "given": "Frank", "initials": "F"}], "type": "journal article", "published": "2020-10-06", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "21", "issue": "19", "issn-l": null}, "abstract": "Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), causing Coronavirus Disease 19 (COVID-19), emerged at the end of 2019 and quickly spread to cause a global pandemic with severe socio-economic consequences. The early sequencing of its RNA genome revealed its high similarity to SARS, likely to have originated from bats. The SARS-CoV-2 non-structural protein 10 (nsp10) displays high sequence similarity with its SARS homologue, which binds to and stimulates the 3'-to-5' exoribonuclease and the 2'-O-methlytransferase activities of nsps 14 and 16, respectively. Here, we report the biophysical characterization and 1.6 \u00c5 resolution structure of the unbound form of nsp10 from SARS-CoV-2 and compare it to the structures of its SARS homologue and the complex-bound form with nsp16 from SARS-CoV-2. The crystal structure and solution behaviour of nsp10 will not only form the basis for understanding the role of SARS-CoV-2 nsp10 as a central player of the viral RNA capping apparatus, but will also serve as a basis for the development of inhibitors of nsp10, interfering with crucial functions of the replication-transcription complex and virus replication.", "doi": "10.3390/ijms21197375", "pmid": "33036230", "labels": {"Type: Journal article": null, "Category: Proteins": null}, "xrefs": [{"db": "PDB", "key": "6ZPE", "description": "Nonstructural protein 10 (nsp10) from SARS CoV-2, 1.58\u00c5 resolution"}, {"db": "PDB", "key": "6ZCT", "description": "Nonstructural protein 10 (nsp10) from SARS CoV-2, 2.55\u00c5 resolution"}, {"db": "URL", "key": "http://www.mdpi.com/1422-0067/21/19/7375/s1", "description": "Supplementary materials"}], "notes": [], "created": "2020-10-30T11:23:12.306Z", "modified": "2021-02-26T08:47:18.875Z"}, {"entity": "publication", "iuid": "0846f729bebd46bab1412900525f7e54", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0846f729bebd46bab1412900525f7e54.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0846f729bebd46bab1412900525f7e54"}}, "title": "Upper Respiratory Tract Levels of Severe Acute Respiratory Syndrome Coronavirus 2 RNA and Duration of Viral RNA Shedding Do Not Differ Between Patients With Mild and Severe/Critical Coronavirus Disease 2019", "authors": [{"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Marklund", "given": "Emelie", "initials": "E"}, {"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Andersson", "given": "Lars Magnus", "initials": "LM"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal-article", "published": "2020-10-05", "journal": {"title": "The Journal of Infectious Diseases", "issn": "0022-1899", "issn-l": null, "volume": "223", "issue": "1", "pages": "15-18"}, "abstract": "This study reports longitudinal viral RNA loads from the nasopharynx/throat in patients with mild and severe/critical coronavirus disease 2019 (COVID-19). We also investigated whether the duration of symptoms correlated with the duration of viral RNA shedding. A total of 56 patients were included. The highest viral loads occurred early after onset of symptoms. Neither the viral RNA loads in the upper respiratory tract nor the time to viral RNA clearance differed between patients with mild or severe/critical disease. There was a moderate correlation between number of days with symptoms and number of days with viral RNA shedding in patients with mild COVID-19.", "doi": "10.1093/infdis/jiaa632", "pmid": "33020822", "labels": {"Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Research Area: Biomarkers and systems immunology": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Genomics & transcriptomics": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-04T07:31:41.074Z", "modified": "2021-06-14T14:40:59.081Z"}, {"entity": "publication", "iuid": "f328480b01e246b5a1721e85548a034f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f328480b01e246b5a1721e85548a034f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f328480b01e246b5a1721e85548a034f"}}, "title": "Testing wastewater to detect severe acute respiratory syndrome coronavirus 2 in communities.", "authors": [{"family": "Harries", "given": "Anthony D", "initials": "AD"}, {"family": "Dar Berger", "given": "Selma", "initials": "S"}, {"family": "Satyanarayana", "given": "Srinath", "initials": "S"}, {"family": "Thekkur", "given": "Pruthu", "initials": "P"}, {"family": "Kumar", "given": "Ajay M V", "initials": "AMV"}], "type": "journal article", "published": "2020-10-05", "journal": {"title": "Trans R Soc Trop Med Hyg", "issn": "1878-3503", "volume": "114", "issue": "10", "pages": "782-783", "issn-l": null}, "abstract": "Research groups around the world are starting to analyse whether wastewater surveillance is a useful tool to monitor the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in communities. Reported studies from the Netherlands, USA, Australia and France have demonstrated that SARS-CoV-2 can be detected and quantified in wastewater, allowing the total number of community infections to be estimated as well as monitoring whether the virus has returned to a community after elimination. Further work is required to improve the quantification of virus, to better detect the virus at low levels and to ensure wastewater samples are representative of the community under surveillance.", "doi": "10.1093/trstmh/traa066", "pmid": "32780856", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "5891256"}, {"db": "pmc", "key": "PMC7454889"}], "notes": [], "created": "2020-12-07T13:32:00.162Z", "modified": "2021-02-26T08:46:13.601Z"}, {"entity": "publication", "iuid": "84b42d7543d34c9ea1ffec8a3f923dd5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84b42d7543d34c9ea1ffec8a3f923dd5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84b42d7543d34c9ea1ffec8a3f923dd5"}}, "title": "Comparing biomarkers for COVID-19 disease with commonly associated preexisting conditions and complications", "authors": [{"family": "Huang", "given": "Jesse", "initials": "J"}], "type": "posted-content", "published": "2020-10-05", "journal": {"title": "", "issn": null, "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1101/2020.10.02.20205609", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-09T19:34:36.434Z", "modified": "2021-06-09T19:34:49.113Z"}, {"entity": "publication", "iuid": "6564dde888cc467cbb4dcb65121bbd2d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6564dde888cc467cbb4dcb65121bbd2d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6564dde888cc467cbb4dcb65121bbd2d"}}, "title": "Safety and efficacy of the Russian COVID-19 vaccine: more information needed.", "authors": [{"family": "Bucci", "given": "Enrico", "initials": "E"}, {"family": "Andreev", "given": "Konstantin", "initials": "K"}, {"family": "Bj\u00f6rkman", "given": "Anders", "initials": "A"}, {"family": "Calogero", "given": "Raffaele Adolfo", "initials": "RA"}, {"family": "Carafoli", "given": "Ernesto", "initials": "E"}, {"family": "Carninci", "given": "Piero", "initials": "P"}, {"family": "Castagnoli", "given": "Paola", "initials": "P"}, {"family": "Cossarizza", "given": "Andrea", "initials": "A"}, {"family": "Mussini", "given": "Cristina", "initials": "C"}, {"family": "Guerin", "given": "Philippe", "initials": "P"}, {"family": "Lipworth", "given": "Brian", "initials": "B"}, {"family": "Sbardella", "given": "Gianluca", "initials": "G"}, {"family": "Stocki", "given": "Teresa", "initials": "T"}, {"family": "Tuosto", "given": "Loretta", "initials": "L"}, {"family": "van Tulleken", "given": "Christoffer", "initials": "C"}, {"family": "Viola", "given": "Antonella", "initials": "A"}], "type": "letter", "published": "2020-10-03", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "396", "issue": "10256", "pages": "e53", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)31960-7", "pmid": "32971041", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31960-7"}, {"db": "pmc", "key": "PMC7503114"}], "notes": [], "created": "2020-12-03T15:08:12.915Z", "modified": "2020-12-03T15:08:12.925Z"}, {"entity": "publication", "iuid": "ca305314e9bd443b94b3913fca99e324", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ca305314e9bd443b94b3913fca99e324.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ca305314e9bd443b94b3913fca99e324"}}, "title": "Improving on and assessing ethical guidelines for digital tracking and tracing systems for pandemics.", "authors": [{"family": "Lundgren", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2020-10-03", "journal": {"title": "Ethics Inf Technol", "issn": "1388-1957", "volume": null, "issue": null, "pages": "1-4", "issn-l": null}, "abstract": "So-called digital tracking and tracing systems (DTTSs) have been proposed as a means to prevent the spread of SARS-CoV-2. There are ethical guidelines and evaluations of such systems available. As part of a research project, I will build on and critically evaluate the foundations of such guidelines. The goal is to provide both incremental improvements of the specific requirements for DTTSs and to present and discuss more fundamental challenge, the risk for indirect effects and slippery slopes. The nature of slippery slopes makes ethical guidelines more difficult since it requires a more complex analysis than, for example, using a checklist allows for.", "doi": "10.1007/s10676-020-09561-z", "pmid": "33041647", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "9561"}, {"db": "pmc", "key": "PMC7532338"}], "notes": [], "created": "2020-12-01T17:20:29.348Z", "modified": "2020-12-01T17:20:29.360Z"}, {"entity": "publication", "iuid": "7b1e089b1173446884e09c71f0a18d9e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b1e089b1173446884e09c71f0a18d9e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b1e089b1173446884e09c71f0a18d9e"}}, "title": "The worldwide clinical trial research response to the COVID-19 pandemic - the first 100 days.", "authors": [{"family": "Janiaud", "given": "Perrine", "initials": "P"}, {"family": "Axfors", "given": "Cathrine", "initials": "C"}, {"family": "Van't Hooft", "given": "Janneke", "initials": "J"}, {"family": "Saccilotto", "given": "Ramon", "initials": "R"}, {"family": "Agarwal", "given": "Arnav", "initials": "A"}, {"family": "Appenzeller-Herzog", "given": "Christian", "initials": "C"}, {"family": "Contopoulos-Ioannidis", "given": "Despina G", "initials": "DG"}, {"family": "Danchev", "given": "Valentin", "initials": "V"}, {"family": "Dirnagl", "given": "Ulrich", "initials": "U"}, {"family": "Ewald", "given": "Hannah", "initials": "H"}, {"family": "Gartlehner", "given": "Gerald", "initials": "G"}, {"family": "Goodman", "given": "Steven N", "initials": "SN"}, {"family": "Haber", "given": "Noah A", "initials": "NA"}, {"family": "Ioannidis", "given": "Angeliki Diotima", "initials": "AD"}, {"family": "Ioannidis", "given": "John P A", "initials": "JPA"}, {"family": "Lythgoe", "given": "Mark P", "initials": "MP"}, {"family": "Ma", "given": "Wenyan", "initials": "W"}, {"family": "Macleod", "given": "Malcolm", "initials": "M"}, {"family": "Mali\u010dki", "given": "Mario", "initials": "M"}, {"family": "Meerpohl", "given": "Joerg J", "initials": "JJ"}, {"family": "Min", "given": "Yan", "initials": "Y"}, {"family": "Moher", "given": "David", "initials": "D"}, {"family": "Nagavci", "given": "Blin", "initials": "B"}, {"family": "Naudet", "given": "Florian", "initials": "F"}, {"family": "Pauli-Magnus", "given": "Christiane", "initials": "C"}, {"family": "O'Sullivan", "given": "Jack W", "initials": "JW"}, {"family": "Riedel", "given": "Nico", "initials": "N"}, {"family": "Roth", "given": "Jan A", "initials": "JA"}, {"family": "Sauermann", "given": "Mandy", "initials": "M"}, {"family": "Schandelmaier", "given": "Stefan", "initials": "S"}, {"family": "Schmitt", "given": "Andreas M", "initials": "AM"}, {"family": "Speich", "given": "Benjamin", "initials": "B"}, {"family": "Williamson", "given": "Paula R", "initials": "PR"}, {"family": "Hemkens", "given": "Lars G", "initials": "LG"}], "type": "journal article", "published": "2020-10-02", "journal": {"title": "F1000Res", "issn": "2046-1402", "issn-l": "2046-1402", "volume": "9", "issue": null, "pages": "1193"}, "abstract": "Background: Never before have clinical trials drawn as much public attention as those testing interventions for COVID-19. We aimed to describe the worldwide COVID-19 clinical research response and its evolution over the first 100 days of the pandemic. Methods: Descriptive analysis of planned, ongoing or completed trials by April 9, 2020 testing any intervention to treat or prevent COVID-19, systematically identified in trial registries, preprint servers, and literature databases. A survey was conducted of all trials to assess their recruitment status up to July 6, 2020. Results: Most of the 689 trials (overall target sample size 396,366) were small (median sample size 120; interquartile range [IQR] 60-300) but randomized (75.8%; n=522) and were often conducted in China (51.1%; n=352) or the USA (11%; n=76). 525 trials (76.2%) planned to include 155,571 hospitalized patients, and 25 (3.6%) planned to include 96,821 health-care workers. Treatments were evaluated in 607 trials (88.1%), frequently antivirals (n=144) or antimalarials (n=112); 78 trials (11.3%) focused on prevention, including 14 vaccine trials. No trial investigated social distancing. Interventions tested in 11 trials with >5,000 participants were also tested in 169 smaller trials (median sample size 273; IQR 90-700). Hydroxychloroquine alone was investigated in 110 trials. While 414 trials (60.0%) expected completion in 2020, only 35 trials (4.1%; 3,071 participants) were completed by July 6. Of 112 trials with detailed recruitment information, 55 had recruited <20% of the targeted sample; 27 between 20-50%; and 30 over 50% (median 14.8% [IQR 2.0-62.0%]). Conclusions: The size and speed of the COVID-19 clinical trials agenda is unprecedented. However, most trials were small investigating a small fraction of treatment options. The feasibility of this research agenda is questionable, and many trials may end in futility, wasting research resources. Much better coordination is needed to respond to global health threats.", "doi": "10.12688/f1000research.26707.2", "pmid": "33082937", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7539080.2"}], "notes": [], "created": "2020-11-19T19:33:08.731Z", "modified": "2022-11-09T09:01:59.475Z"}, {"entity": "publication", "iuid": "0b339525d3774ee0bbe33c3f9eb82687", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b339525d3774ee0bbe33c3f9eb82687.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b339525d3774ee0bbe33c3f9eb82687"}}, "title": "The COVID-19 outbreak and approaches to performing EEG in Europe.", "authors": [{"family": "Krysl", "given": "David", "initials": "D"}, {"family": "Beniczky", "given": "S\u00e1ndor", "initials": "S"}, {"family": "Franceschetti", "given": "Silvana", "initials": "S"}, {"family": "Arzimanoglou", "given": "Alexis", "initials": "A"}], "type": "journal article", "published": "2020-10-01", "journal": {"title": "Epileptic Disord", "issn": "1950-6945", "issn-l": null, "volume": "22", "issue": "5", "pages": "548-554"}, "abstract": "The coronavirus SARS-CoV-2 disease (COVID-19) pandemic affects availability and performance of neurophysiological diagnostic methods, including EEG. Our objective was to outline the current situation regarding EEG-based investigations across Europe. A web-based survey was distributed to centres within the European Reference Network on rare and complex epilepsies (ERN EpiCARE). Responses were collected between April 9 and May 15, 2020. Results were analysed with Microsoft Excel, Python Pandas and SciPy. Representants from 47 EpiCARE centres from 22 countries completed the survey. At the time of completing the survey, inpatient video-EEGs had been stopped or restricted in most centres (61.7% vs. 36.2% for adults, and 38.3% vs. 53.2% for children). Invasive investigations and epilepsy surgery were similarly affected. Acute EEGs continued to be performed, while indications for outpatient EEGs were limited and COVID-19 triage put in place. The strictness of measures varied according to extent of the outbreak in a given country. The results indicate a profound impact of COVID-19 on neurophysiological diagnostics, especially inpatient video-EEGs, invasive investigations, and epilepsy surgery. The COVID-19 pandemic may hamper care for patients in need of EEG-based investigations, particularly patients with seizure disorders. ERN EpiCARE will work on recommendations on how to rapidly adapt to such situations in order to alleviate consequences for our patients.", "doi": "10.1684/epd.2020.1208", "pmid": "33095171", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "epd.2020.1208"}], "notes": [], "created": "2020-12-01T15:35:43.413Z", "modified": "2021-02-26T08:46:12.902Z"}, {"entity": "publication", "iuid": "3714d5962dfe4aa4bed16288c686fa97", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3714d5962dfe4aa4bed16288c686fa97.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3714d5962dfe4aa4bed16288c686fa97"}}, "title": "Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19.", "authors": [{"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "Perez-Potti", "given": "Andr\u00e9", "initials": "A"}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Gorin", "given": "Jean-Baptiste", "initials": "J"}, {"family": "Olsson", "given": "Annika", "initials": "A"}, {"family": "Llewellyn-Lacey", "given": "Sian", "initials": "S"}, {"family": "Kamal", "given": "Habiba", "initials": "H"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Wullimann", "given": "David J", "initials": "DJ"}, {"family": "Kammann", "given": "Tobias", "initials": "T"}, {"family": "Emg\u00e5rd", "given": "Johanna", "initials": "J"}, {"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Folkesson", "given": "Elin", "initials": "E"}, {"family": "Karolinska COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Henter", "given": "Jan-Inge", "initials": "J"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Allander", "given": "Tobias", "initials": "T"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Nielsen", "given": "Morten", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Price", "given": "David A", "initials": "DA"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}], "type": "journal article", "published": "2020-10-01", "journal": {"title": "Cell", "issn": "1097-4172", "issn-l": "0092-8674", "volume": "183", "issue": "1", "pages": "158-168.e14"}, "abstract": "SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.", "doi": "10.1016/j.cell.2020.08.017", "pmid": "32979941", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Genomics & transcriptomics": null, "Category: Other": null, "Category: Proteins": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.1016/j.cell.2020.08.017", "description": "Supplementary materials: predicted binding affinities, donor characteristics, sample information, and some analyses"}, {"db": "NA", "key": "All data included in the paper", "description": null}], "notes": [], "created": "2020-10-28T09:03:34.190Z", "modified": "2021-11-18T09:21:57.000Z"}, {"entity": "publication", "iuid": "ea5eacb93e4747ee98374542036f42a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ea5eacb93e4747ee98374542036f42a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ea5eacb93e4747ee98374542036f42a9"}}, "title": "Nitric oxide dosed in short bursts at high concentrations may protect against Covid 19.", "authors": [{"family": "Hedenstierna", "given": "G\u00f6ran", "initials": "G"}, {"family": "Chen", "given": "Luni", "initials": "L"}, {"family": "Hedenstierna", "given": "Magnus", "initials": "M"}, {"family": "Lieberman", "given": "Robert", "initials": "R"}, {"family": "Fine", "given": "David H", "initials": "DH"}], "type": "journal article", "published": "2020-10-01", "journal": {"title": "Nitric Oxide", "issn": "1089-8611", "issn-l": "1089-8603", "volume": "103", "issue": null, "pages": "1-3"}, "abstract": "It has long been suggested that NO may inhibit an early stage in viral replication. Furthermore, in vitro tests have shown that NO inhibits the replication cycle of severe acute respiratory syndrome coronavirus. Despite smoking being listed as a risk factor to contract Covid-19, only a low proportion of the smokers suffered from SARS-corona infection in China 2003, and from Covid-19 in China, Europe and the US. We hypothesize, that the intermittent bursts of high NO concentration in cigarette smoke may be a mechanism in protecting against the virus. Mainstream smoke from cigarettes contains NO at peak concentrations of between about 250 ppm and 1350 ppm in each puff as compared to medicinal use of no more than 80 to a maximum of 160 ppm. The diffusion of NO through the cell wall to reach the virus should be significantly more effective at the very high NO concentration in the smoke, according to classic laws of physics. The only oxide of nitrogen in the mainstream smoke is NO, and the NO 2 concentration that is inhaled is very low or undetectable, and methemoglobin levels are lower in smokers than non-smokers, reasonably explained by the breaths of air in between the puffs that wash out the NO. Specialized iNO machines can now be developed to provide the drug intermittently in short bursts at high concentration dose, which would then provide both a preventative drug for those at high risk, as well as an effective treatment, without the health hazards associated with smoking.", "doi": "10.1016/j.niox.2020.06.005", "pmid": "32590117", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1089-8603(20)30161-0"}], "notes": [], "created": "2020-11-18T17:31:13.966Z", "modified": "2022-11-09T09:05:12.512Z"}, {"entity": "publication", "iuid": "8adbd429360c459896c97d05c262fe58", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8adbd429360c459896c97d05c262fe58.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8adbd429360c459896c97d05c262fe58"}}, "title": "Injuries From Asymptomatic COVID-19 Disease: New Hidden Toxicity Risk Factors in Thoracic Radiation Therapy.", "authors": [{"family": "Cella", "given": "Laura", "initials": "L"}, {"family": "Gagliardi", "given": "Giovanna", "initials": "G"}, {"family": "Hedman", "given": "Mattias", "initials": "M"}, {"family": "Palma", "given": "Giuseppe", "initials": "G"}], "type": "editorial", "published": "2020-10-01", "journal": {"title": "Int J Radiat Oncol Biol Phys", "issn": "1879-355X", "volume": "108", "issue": "2", "pages": "394-396", "issn-l": null}, "abstract": null, "doi": "10.1016/j.ijrobp.2020.06.055", "pmid": "32890518", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0360-3016(20)31342-0"}, {"db": "pmc", "key": "PMC7462877"}], "notes": [], "created": "2020-12-06T07:23:44.506Z", "modified": "2020-12-06T07:24:52.091Z"}, {"entity": "publication", "iuid": "e6a43c1c7bad40cc931b0b4b61b9ae1a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6a43c1c7bad40cc931b0b4b61b9ae1a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6a43c1c7bad40cc931b0b4b61b9ae1a"}}, "title": "In search of the relevant COVID research", "authors": [{"family": "Allebeck", "given": "Peter", "initials": "P", "orcid": "0000-0002-2778-6467", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de9f0e1c3e4d402b93e61ad1c5a771fb.json"}}, {"family": "S\u00f6rberg Wallin", "given": "Alma", "initials": "A", "orcid": "0000-0002-8804-095X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bdaa3ba8e9c149a6b4c05d924f31d0e5.json"}}], "type": "journal-article", "published": "2020-10-01", "journal": {"title": "Eur J Public Health", "issn": "1101-1262", "volume": "30", "issue": "5", "pages": "850-851", "issn-l": null}, "abstract": null, "doi": "10.1093/eurpub/ckaa169", "pmid": "32818271", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7536247"}, {"db": "pii", "key": "5894973"}], "notes": [], "created": "2020-12-07T12:24:48.738Z", "modified": "2023-06-19T07:32:18.110Z"}, {"entity": "publication", "iuid": "bf3c55cfd0094f7f84d20a9e3b1a934b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf3c55cfd0094f7f84d20a9e3b1a934b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf3c55cfd0094f7f84d20a9e3b1a934b"}}, "title": "Extracorporeal membrane oxygenation in children with COVID-19: Preliminary report from the collaborative EuroELSO prospective survey.", "authors": [{"family": "Di Nardo", "given": "M", "initials": "M"}, {"family": "Hoskote", "given": "A", "initials": "A"}, {"family": "Thiruchelvam", "given": "T", "initials": "T"}, {"family": "Lillie", "given": "J", "initials": "J"}, {"family": "Horan", "given": "M", "initials": "M"}, {"family": "Belda Hofheinz", "given": "S", "initials": "S"}, {"family": "Dupic", "given": "L", "initials": "L"}, {"family": "Gimeno", "given": "R", "initials": "R"}, {"family": "De Piero", "given": "M E", "initials": "ME"}, {"family": "Lo Coco", "given": "V", "initials": "V"}, {"family": "Roeleveld", "given": "P", "initials": "P"}, {"family": "Davidson", "given": "M", "initials": "M"}, {"family": "Jones", "given": "T", "initials": "T"}, {"family": "Broman", "given": "L M", "initials": "LM"}, {"family": "Lorusso", "given": "R", "initials": "R"}, {"family": "Belohlavek", "given": "J", "initials": "J"}, {"family": "EuroELSO Neonatal & Pediatric Working Group & collaborators on COVID-19", "given": "", "initials": ""}], "type": "journal article", "published": "2020-10-01", "journal": {"title": "ASAIO J", "issn": "1538-943X", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Perspective", "doi": "10.1097/MAT.0000000000001309", "pmid": "33009172", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-03T08:58:24.297Z", "modified": "2020-12-03T08:59:18.873Z"}, {"entity": "publication", "iuid": "87d2e0c1a45746429254b6b2c9d5c732", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87d2e0c1a45746429254b6b2c9d5c732.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87d2e0c1a45746429254b6b2c9d5c732"}}, "title": "Exploring views and experiences of how infections are detected and managed in practice by nurses, care workers and manager's in nursing homes in England and Sweden: a survey protocol.", "authors": [{"family": "Carey", "given": "N", "initials": "N"}, {"family": "Alkhamees", "given": "Nouf", "initials": "N"}, {"family": "Cox", "given": "Anna", "initials": "A"}, {"family": "Sund-Levander", "given": "Marta", "initials": "M"}, {"family": "Tingstr\u00f6m", "given": "Pia", "initials": "P"}, {"family": "Mold", "given": "Freda", "initials": "F"}], "type": "journal article", "published": "2020-10-01", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "10", "issue": "10", "pages": "e038390"}, "abstract": "In order to avoid unnecessary hospital admission and associated complications, there is an urgent need to improve the early detection of infection in nursing home residents. Monitoring signs and symptoms with checklists or aids called decision support tools may help nursing home staff to detect infection in residents, particularly during the current COVID-19 pandemic.We plan to conduct a survey exploring views and experiences of how infections are detected and managed in practice by nurses, care workers and managers in nursing homes in England and Sweden.\r\n\r\nAn international cross-sectional descriptive survey, using a pretested questionnaire, will be used to explore nurses, care workers and managers views and experiences of how infections are detected and managed in practice in nursing homes. Data will be analysed descriptively and univariate associations between personal and organisational factors explored. This will help identify important factors related to awareness, knowledge, attitudes, belief and skills likely to affect future implementation of a decision support tool for the early detection of infection in nursing home residents.\r\n\r\nThis study was approved using the self-certification process at the University of Surrey and Link\u00f6ping University ethics committee (Approval 2018/514-32) in 2018. Study findings will be disseminated through community/stakeholder/service user engagement events in each country, publication in academic peer-reviewed journals and conference presentations. A LAY summary will be provided to participants who indicate they would like to receive this information.This is the first stage of a plan of work to revise and evaluate the Early Detection of Infection Scale (EDIS) tool and its effect on managing infections and reducing unplanned hospital admissions in nursing home residents. Implementation of the EDIS tool may have important implications for the healthcare economy; this will be explored in cost-benefit analyses as the work progresses.", "doi": "10.1136/bmjopen-2020-038390", "pmid": "33004397", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-038390"}, {"db": "pmc", "key": "PMC7534694"}], "notes": [], "created": "2020-12-03T08:59:56.608Z", "modified": "2022-11-09T09:06:09.469Z"}, {"entity": "publication", "iuid": "41ec42fe6a674cf0bebd830f2d7ed408", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41ec42fe6a674cf0bebd830f2d7ed408.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41ec42fe6a674cf0bebd830f2d7ed408"}}, "title": "Early lessons from COVID-19 response and shifts in authority: public trust, policy legitimacy and political inclusion.", "authors": [{"family": "Bekker", "given": "Marleen", "initials": "M"}, {"family": "Ivankovic", "given": "Damir", "initials": "D"}, {"family": "Biermann", "given": "Olivia", "initials": "O"}], "type": "journal article", "published": "2020-10-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "volume": "30", "issue": "5", "pages": "854-855", "issn-l": "1101-1262"}, "abstract": null, "doi": "10.1093/eurpub/ckaa181", "pmid": "33020828", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "5918171"}, {"db": "pmc", "key": "PMC7665464"}], "notes": [], "created": "2020-12-01T18:17:21.351Z", "modified": "2020-12-01T18:17:45.967Z"}, {"entity": "publication", "iuid": "c8d295439f1242699d9db621b035dca5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c8d295439f1242699d9db621b035dca5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c8d295439f1242699d9db621b035dca5"}}, "title": "Coping behaviors associated with decreased anxiety and depressive symptoms during the COVID-19 pandemic and lockdown.", "authors": [{"family": "Fullana", "given": "Miquel A", "initials": "MA"}, {"family": "Hidalgo-Mazzei", "given": "Diego", "initials": "D"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}], "type": "letter", "published": "2020-10-01", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "issn-l": null, "volume": "275", "issue": null, "pages": "80-81"}, "abstract": "The COVID-19 pandemic and lockdown might increase anxiety and depressive symptoms, but some behaviors may protect against them.\r\n\r\nTo provide a preliminary evidence of the behaviors associated with decreased symptoms in the current COVID-19 pandemic and lockdown, we conducted a survey of 5545 adult individuals from the Spanish general population, two weeks after an official lockdown was established across the country.\r\n\r\nSixty-five percent of the sample reported anxiety or depressive symptoms. Following a healthy/balanced diet and not reading news/updates about COVID-19 very often were the best predictors of lower levels of anxiety symptoms. Following a healthy/balanced diet, following a routine, not reading news/updates about COVID-19 very often, taking the opportunity to pursue hobbies, and staying outdoors or looking outside were the best predictors of lower levels of depressive symptoms.\r\n\r\nCross-sectional nature and use of sample of convenience.\r\n\r\nThis study suggests that \"simple\" coping behaviors may protect against anxiety and depressive symptoms during the COVID-19 pandemic and lockdown.", "doi": "10.1016/j.jad.2020.06.027", "pmid": "32658829", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0165-0327(20)32385-5"}, {"db": "pmc", "key": "PMC7329680"}], "notes": [], "created": "2020-12-08T14:12:49.935Z", "modified": "2022-11-09T09:07:06.608Z"}, {"entity": "publication", "iuid": "39063093dd1344619fa982e652ac2867", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/39063093dd1344619fa982e652ac2867.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/39063093dd1344619fa982e652ac2867"}}, "title": "What will the long-lasting effect of the COVID-19 pandemic be on children's health and wellbeing?", "authors": [{"family": "Alfv\u00e9n", "given": "Tobias", "initials": "T"}], "type": "editorial", "published": "2020-10-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": "109", "issue": "10", "pages": "1924-1925"}, "abstract": "Editorial", "doi": "10.1111/apa.15513", "pmid": "32870545", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-07T07:48:22.434Z", "modified": "2020-12-07T07:48:47.205Z"}, {"entity": "publication", "iuid": "3110e37d5cb6405fa6a57bb42975d2ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3110e37d5cb6405fa6a57bb42975d2ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3110e37d5cb6405fa6a57bb42975d2ca"}}, "title": "What to expect for the influenza season 2020/21 with the ongoing COVID-19 pandemic in the World Health Organization European Region.", "authors": [{"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Pebody", "given": "Richard", "initials": "R"}], "type": "editorial", "published": "2020-10-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "25", "issue": "42", "pages": null}, "abstract": "Editorial", "doi": "10.2807/1560-7917.ES.2020.25.42.2001816", "pmid": "33094719", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7651872"}], "notes": [], "created": "2020-12-01T15:36:42.114Z", "modified": "2020-12-11T12:47:41.046Z"}, {"entity": "publication", "iuid": "abdab7a0dd85434b9d24eb8a689e7e6f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abdab7a0dd85434b9d24eb8a689e7e6f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abdab7a0dd85434b9d24eb8a689e7e6f"}}, "title": "Unraveling the Immune Response in Severe COVID-19", "authors": [{"family": "Rodriguez", "given": "Lucie", "initials": "L"}, {"family": "Brodin", "given": "Petter", "initials": "P"}], "type": "journal-article", "published": "2020-10-00", "journal": {"title": "J Clin Immunol", "issn": "0271-9142", "issn-l": null, "volume": "40", "issue": "7", "pages": "958-959"}, "abstract": "Comment", "doi": "10.1007/s10875-020-00849-9", "pmid": "32827284", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-04T15:15:07.666Z", "modified": "2021-01-11T10:50:50.121Z"}, {"entity": "publication", "iuid": "d15ae52217704044b6357eda9c434dbb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d15ae52217704044b6357eda9c434dbb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d15ae52217704044b6357eda9c434dbb"}}, "title": "Treating patients with cancer amidst the COVID-19 pandemic: experience of a regional hospital in the Piedmont region in northern Italy", "authors": [{"family": "Garrone", "given": "Ornella", "initials": "O"}, {"family": "Denaro", "given": "Nerina", "initials": "N"}, {"family": "Ruatta", "given": "Fiorella", "initials": "F"}, {"family": "Vanella", "given": "Paola", "initials": "P"}, {"family": "Granetto", "given": "Cristina", "initials": "C"}, {"family": "Vandone", "given": "Anna Maria", "initials": "AM"}, {"family": "Occelli", "given": "Marcella", "initials": "M"}, {"family": "Cauchi", "given": "Carolina", "initials": "C"}, {"family": "Ricci", "given": "Vincenzo", "initials": "V"}, {"family": "Fea", "given": "Elena", "initials": "E"}, {"family": "Di Costanzo", "given": "Gianna", "initials": "G"}, {"family": "Colantonio", "given": "Ida", "initials": "I"}, {"family": "Crosetto", "given": "Nicola", "initials": "N"}, {"family": "Merlano", "given": "Marco C", "initials": "MC"}], "type": "journal-article", "published": "2020-10-00", "journal": {"title": "Tumori", "issn": "0300-8916", "issn-l": null, "volume": "106", "issue": "5", "pages": "427-431"}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic is posing an unprecedented dilemma to oncologists worldwide, forcing them to decide whether to continue or suspend treatments in order to protect their most vulnerable patients from infection. After the first report from China, the outbreak spread rapidly worldwide. To, date no clear indications on how to treat patients with cancer with COVID-19 infection are available.\r\n\r\nWe report data on 21 patients with cancer referred to a single medical oncology unit of a general hospital from mid-March to April 23, 2020.\r\n\r\nNine patients were on active cancer therapy during the infection and all stopped medical treatments. Overall 8 patients developed pneumonia and 6 patients died of COVID-19.\r\n\r\nThe management of patients with cancer during the pandemic should be carefully balanced and discussed among oncologists and other key professionals involved in the treatment of this vulnerable group of patients, in order to balance the risk of treatment and the risk of infection.", "doi": "10.1177/0300891620942313", "pmid": "32703089", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Serology": null}, "xrefs": [], "notes": [], "created": "2020-11-04T16:12:10.666Z", "modified": "2021-02-26T08:46:49.391Z"}, {"entity": "publication", "iuid": "2e208a260070478a86af9d6ad8e3bcf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e208a260070478a86af9d6ad8e3bcf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e208a260070478a86af9d6ad8e3bcf3"}}, "title": "Tracking Potential COVID-19 Outbreaks With Influenzalike Symptoms Urgent Care Visits.", "authors": [{"family": "Muchmore", "given": "Brian", "initials": "B"}, {"family": "Muchmore", "given": "Patrick", "initials": "P"}, {"family": "Lee", "given": "Chi Wing", "initials": "CW"}, {"family": "Alarc\u00f3n-Riquelme", "given": "Marta E", "initials": "ME"}, {"family": "Muchmore", "given": "Andrew", "initials": "A"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Pediatrics", "issn": "1098-4275", "volume": "146", "issue": "4", "issn-l": null}, "abstract": null, "doi": "10.1542/peds.2020-1798", "pmid": "32699069", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "peds.2020-1798"}], "notes": [], "created": "2020-12-07T16:23:06.401Z", "modified": "2020-12-07T16:23:29.349Z"}, {"entity": "publication", "iuid": "e42a35963dbb42b3bf0375853434ff79", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e42a35963dbb42b3bf0375853434ff79.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e42a35963dbb42b3bf0375853434ff79"}}, "title": "The scope of mental health research during the COVID-19 pandemic and its aftermath.", "authors": [{"family": "Hotopf", "given": "Matthew", "initials": "M"}, {"family": "Bullmore", "given": "Ed", "initials": "E"}, {"family": "O'Connor", "given": "Rory C", "initials": "RC"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Br J Psychiatry", "issn": "1472-1465", "volume": "217", "issue": "4", "pages": "540-542", "issn-l": "0007-1250"}, "abstract": "The effects of the COVID-19 pandemic on population mental health are unknown. We need to understand the scale of any such impact in different sections of the population, who is most affected and how best to mitigate, prevent and treat any excess morbidity. We propose a coordinated and interdisciplinary mental health science response.", "doi": "10.1192/bjp.2020.125", "pmid": "32493516", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0007125020001257"}, {"db": "pmc", "key": "PMC7330278"}], "notes": [], "created": "2020-11-19T19:24:00.166Z", "modified": "2020-12-09T10:49:57.015Z"}, {"entity": "publication", "iuid": "57349b4780174ff1a804f9c0301aee0d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/57349b4780174ff1a804f9c0301aee0d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/57349b4780174ff1a804f9c0301aee0d"}}, "title": "The mediating effect of the cyberchondria and anxiety sensitivity in the association between problematic internet use, metacognition beliefs, and fear of COVID-19 among Iranian online population.", "authors": [{"family": "Seyed Hashemi", "given": "Seyed Ghasem", "initials": "SG"}, {"family": "Hosseinnezhad", "given": "Shalaleh", "initials": "S"}, {"family": "Dini", "given": "Solmaz", "initials": "S"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "issn-l": null, "volume": "6", "issue": "10", "pages": "e05135"}, "abstract": "With the rapid growth of the novel coronavirus disease 2019 (COVID-19), individuals may try to find related medical information using the internet to overcome their fears. Under such circumstances, individuals with the features of cyberchondria, anxiety sensitivity, and metacognitive beliefs in negative thoughts may suffer more fears than those without these features. Therefore, the present study proposed a model to understand the associations between problematic internet use (PIU), cyberchondria, anxiety sensitivity, metacognition beliefs, and fear of COVID-19. Utilizing a cross-sectional online survey, 651 Iranians completed the following psychometric scales: Metacognition Questionnaire-30 (MCQ-30), Anxiety Sensitivity Questionnaire (ASI), Cyberchondria Severity Scale-Short Form (CSS-12), Fear of COVID-19 Scale (FCV-19S), and Generalized Problematic Internet Use Scale (GPIUS). Structural equation modeling (SEM) was used to assess the proposed model via several fit indices. The indices include Tucker-Lewis index (TLI), comparative fit index (CFI), standardized root mean square residual (SRMR), and root mean square error of approximation (RMSEA). The fit indices (CFI = 0.948, TLI = 0.938, RMSEA = 0.053, and SRMR = 0.001) indicated the good fit between the data and the proposed model. Moreover, fear of COVID-19 was significantly and directly predicted by cyberchondria (\u03b2 = 0.479, p < .001) and anxiety sensitivity (\u03b2 = 0.286, p < .001). The relationship between PIU and cyberchondria with fear of COVID-19 was mediated significantly by anxiety sensitivity and metacognitive beliefs. Because fear of COVID-19 was found to be significantly associated with cyberchondria and anxiety sensitivity, healthcare providers may want to provide additional support for those with cyberchondria and anxiety sensitivity tendencies.", "doi": "10.1016/j.heliyon.2020.e05135", "pmid": "33072911", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(20)31978-2"}, {"db": "pmc", "key": "PMC7547399"}], "notes": [], "created": "2020-12-01T17:02:50.671Z", "modified": "2022-11-09T09:08:08.956Z"}, {"entity": "publication", "iuid": "53e0c79e38674500b109629509265e6e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53e0c79e38674500b109629509265e6e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53e0c79e38674500b109629509265e6e"}}, "title": "The impact of COVID-19 on research.", "authors": [{"family": "Harper", "given": "L", "initials": "L"}, {"family": "Kalfa", "given": "N", "initials": "N"}, {"family": "Beckers", "given": "G M A", "initials": "GMA"}, {"family": "Kaefer", "given": "M", "initials": "M"}, {"family": "Nieuwhof-Leppink", "given": "A J", "initials": "AJ"}, {"family": "Fossum", "given": "Magdalena", "initials": "M"}, {"family": "Herbst", "given": "K W", "initials": "KW"}, {"family": "Bagli", "given": "D", "initials": "D"}, {"family": "ESPU Research Committee", "given": "", "initials": ""}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "J Pediatr Urol", "issn": "1873-4898", "volume": "16", "issue": "5", "pages": "715-716", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jpurol.2020.07.002", "pmid": "32713792", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1477-5131(20)30412-5"}, {"db": "pmc", "key": "PMC7343645"}], "notes": [], "created": "2020-12-07T16:13:37.865Z", "modified": "2020-12-07T16:13:37.891Z"}, {"entity": "publication", "iuid": "00fdf422a3cd461bb84a16cfec56bc74", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/00fdf422a3cd461bb84a16cfec56bc74.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/00fdf422a3cd461bb84a16cfec56bc74"}}, "title": "The impact of COVID-19 on contraception and abortion care policy and practice: experiences from selected countries.", "authors": [{"family": "Bateson", "given": "Deborah J", "initials": "DJ"}, {"family": "Lohr", "given": "Patricia A", "initials": "PA"}, {"family": "Norman", "given": "Wendy V", "initials": "WV"}, {"family": "Moreau", "given": "Caroline", "initials": "C"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}, {"family": "Blumenthal", "given": "Paul D", "initials": "PD"}, {"family": "Hoggart", "given": "Lesley", "initials": "L"}, {"family": "Li", "given": "Hang-Wun Raymond", "initials": "HR"}, {"family": "Aiken", "given": "Abigail R A", "initials": "ARA"}, {"family": "Black", "given": "Kirsten I", "initials": "KI"}], "type": "editorial", "published": "2020-10-00", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-2009", "issn-l": "2515-1991", "volume": "46", "issue": "4", "pages": "241-243"}, "abstract": null, "doi": "10.1136/bmjsrh-2020-200709", "pmid": "32788180", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjsrh-2020-200709"}], "notes": [], "created": "2020-12-07T13:28:03.197Z", "modified": "2021-02-26T08:46:59.783Z"}, {"entity": "publication", "iuid": "772a3dbc1c954feda18fa8b7a7f68aaa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/772a3dbc1c954feda18fa8b7a7f68aaa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/772a3dbc1c954feda18fa8b7a7f68aaa"}}, "title": "The immuno-oncological challenge of COVID-19.", "authors": [{"family": "Derosa", "given": "Lisa", "initials": "L"}, {"family": "Melenotte", "given": "Cl\u00e9a", "initials": "C"}, {"family": "Griscelli", "given": "Franck", "initials": "F"}, {"family": "Gachot", "given": "Bertrand", "initials": "B"}, {"family": "Marabelle", "given": "Aur\u00e9lien", "initials": "A"}, {"family": "Kroemer", "given": "Guido", "initials": "G", "orcid": "0000-0002-9334-4405", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d17de2122d0429eaa48a733bf2ad28e.json"}}, {"family": "Zitvogel", "given": "Laurence", "initials": "L", "orcid": "0000-0003-1596-0998", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b10947c1a2b4884b3f502625a28c5e0.json"}}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Nat Cancer", "issn": "2662-1347", "volume": "1", "issue": "10", "pages": "946-964", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) and its causative virus, SARS-CoV-2, pose considerable challenges for the management of oncology patients. COVID-19 presents as a particularly severe respiratory and systemic infection in aging and immunosuppressed individuals, including patients with cancer. Moreover, severe COVID-19 is linked to an inflammatory burst and lymphopenia, which may aggravate cancer prognosis. Here we discuss why those with cancer are at higher risk of severe COVID-19, describe immune responses that confer protective or adverse reactions to this disease and indicate which antineoplastic therapies may either increase COVID-19 vulnerability or have a dual therapeutic effect on cancer and COVID-19.", "doi": "10.1038/s43018-020-00122-3", "pmid": "35121872", "labels": {"Type: Other": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s43018-020-00122-3"}], "notes": [], "created": "2023-01-13T13:38:05.320Z", "modified": "2023-01-13T13:38:05.345Z"}, {"entity": "publication", "iuid": "28cd389d36e14115adf57031c5a35ffe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/28cd389d36e14115adf57031c5a35ffe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/28cd389d36e14115adf57031c5a35ffe"}}, "title": "The Post COVID-19 Surgical Backlog: Now is the Time to Implement Enhanced Recovery After Surgery (ERAS).", "authors": [{"family": "Ljungqvist", "given": "Olle", "initials": "O"}, {"family": "Nelson", "given": "Gregg", "initials": "G"}, {"family": "Demartines", "given": "Nicolas", "initials": "N"}], "type": "editorial", "published": "2020-10-00", "journal": {"title": "World J Surg", "issn": "1432-2323", "volume": "44", "issue": "10", "pages": "3197-3198", "issn-l": null}, "abstract": null, "doi": "10.1007/s00268-020-05734-5", "pmid": "32803298", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00268-020-05734-5"}, {"db": "pmc", "key": "PMC7427753"}], "notes": [], "created": "2020-12-07T13:21:01.304Z", "modified": "2020-12-07T13:21:34.806Z"}, {"entity": "publication", "iuid": "6a70ee06a5b64d49858744269591ecf7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a70ee06a5b64d49858744269591ecf7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a70ee06a5b64d49858744269591ecf7"}}, "title": "Symptoms of a broken system: the gender gaps in COVID-19 decision-making.", "authors": [{"family": "van Daalen", "given": "Kim Robin", "initials": "KR"}, {"family": "Bajnoczki", "given": "Csongor", "initials": "C"}, {"family": "Chowdhury", "given": "Maisoon", "initials": "M"}, {"family": "Dada", "given": "Sara", "initials": "S"}, {"family": "Khorsand", "given": "Parnian", "initials": "P"}, {"family": "Socha", "given": "Anna", "initials": "A"}, {"family": "Lal", "given": "Arush", "initials": "A"}, {"family": "Jung", "given": "Laura", "initials": "L"}, {"family": "Alqodmani", "given": "Lujain", "initials": "L"}, {"family": "Torres", "given": "Irene", "initials": "I"}, {"family": "Ouedraogo", "given": "Samiratou", "initials": "S"}, {"family": "Mahmud", "given": "Amina Jama", "initials": "AJ"}, {"family": "Dhatt", "given": "Roopa", "initials": "R"}, {"family": "Phelan", "given": "Alexandra", "initials": "A"}, {"family": "Rajan", "given": "Dheepa", "initials": "D"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "5", "issue": "10", "pages": null, "issn-l": "2059-7908"}, "abstract": "Commentary", "doi": "10.1136/bmjgh-2020-003549", "pmid": "33004348", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-003549"}, {"db": "pmc", "key": "PMC7533958"}], "notes": [], "created": "2020-11-22T08:50:53.440Z", "modified": "2020-12-03T09:00:30.143Z"}, {"entity": "publication", "iuid": "3c717a035dbb4f3099e07a2a3beb9de5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3c717a035dbb4f3099e07a2a3beb9de5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3c717a035dbb4f3099e07a2a3beb9de5"}}, "title": "Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population.", "authors": [{"family": "Ciabattini", "given": "Annalisa", "initials": "A"}, {"family": "Garagnani", "given": "Paolo", "initials": "P"}, {"family": "Santoro", "given": "Francesco", "initials": "F"}, {"family": "Rappuoli", "given": "Rino", "initials": "R"}, {"family": "Franceschi", "given": "Claudio", "initials": "C"}, {"family": "Medaglini", "given": "Donata", "initials": "D"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Semin Immunopathol", "issn": "1863-2300", "volume": "42", "issue": "5", "pages": "619-634", "issn-l": "1863-2297"}, "abstract": "The SARS-CoV-2 pandemic urgently calls for the development of effective preventive tools. COVID-19 hits greatly the elder and more fragile fraction of the population boosting the evergreen issue of the vaccination of older people. The development of a vaccine against SARS-CoV-2 tailored for the elderly population faces the challenge of the poor immune responsiveness of the older population due to immunosenescence, comorbidities, and pharmacological treatments. Moreover, it is likely that the inflammaging phenotype associated with age could both influence vaccination efficacy and exacerbate the risk of COVID-19-related \"cytokine storm syndrome\" with an overlap between the factors which impact vaccination effectiveness and those that boost virulence and worsen the prognosis of SARS-CoV-2 infection. The complex and still unclear immunopathological mechanisms of SARS-CoV-2 infection, together with the progressive age-related decline of immune responses, and the lack of clear correlates of protection, make the design of vaccination strategies for older people extremely challenging. In the ongoing effort in vaccine development, different SARS-CoV-2 vaccine candidates have been developed, tested in pre-clinical and clinical studies and are undergoing clinical testing, but only a small fraction of these are currently being tested in the older fraction of the population. Recent advances in systems biology integrating clinical, immunologic, and omics data can help to identify stable and robust markers of vaccine response and move towards a better understanding of SARS-CoV-2 vaccine responses in the elderly.", "doi": "10.1007/s00281-020-00821-0", "pmid": "33159214", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00281-020-00821-0"}, {"db": "pmc", "key": "PMC7646713"}], "notes": [], "created": "2020-11-26T12:26:46.196Z", "modified": "2020-11-27T10:08:00.584Z"}, {"entity": "publication", "iuid": "0dec90693fd642e1a368638f5da7892b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0dec90693fd642e1a368638f5da7892b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0dec90693fd642e1a368638f5da7892b"}}, "title": "Risks, resilience, and pathways to sustainable aviation: A COVID-19 perspective.", "authors": [{"family": "G\u00f6ssling", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "J Air Transp Manag", "issn": "1873-2089", "volume": "89", "issue": null, "pages": "101933", "issn-l": null}, "abstract": "This paper discusses the COVID-19 pandemic as an opportunity to reconsider the foundations of the global aviation system. There is much evidence that air transport creates opportunities as well as risks. While the former accrue to businesses and individuals, risks are imposed on society. Pandemics, in which aviation has a role as a vector of pathogen distribution, as well as the sector's contribution to climate change are examples of long-standing negative externalities that continue to be ignored in assessments of aviation's economic performance and societal importance. As commercial aviation has shown limited economic resilience throughout its history, this short paper questions whether a return to business-as-usual, supported by very significant State aid payments, is desirable. The volume growth model championed by industry and aviation proponents may have to be replaced with an alternative model of a slimmed air transport system that is economically less vulnerable and accounting for its environmental impacts.", "doi": "10.1016/j.jairtraman.2020.101933", "pmid": "32952322", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0969-6997(20)30516-0"}, {"db": "pmc", "key": "PMC7492147"}], "notes": [], "created": "2020-12-03T09:33:48.678Z", "modified": "2020-12-03T09:33:48.703Z"}, {"entity": "publication", "iuid": "3fd62190ee1d459bbeb4b5f3eb01129c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3fd62190ee1d459bbeb4b5f3eb01129c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3fd62190ee1d459bbeb4b5f3eb01129c"}}, "title": "Returning to digestive endoscopy normality will be slow and must include novelty and telemedicine.", "authors": [{"family": "Koulaouzidis", "given": "Anastasios", "initials": "A"}, {"family": "Marlicz", "given": "Wojciech", "initials": "W"}, {"family": "Wenzek", "given": "Hagen", "initials": "H"}, {"family": "Koulaouzidis", "given": "George", "initials": "G"}, {"family": "Eliakim", "given": "Rami", "initials": "R"}, {"family": "Toth", "given": "Ervin", "initials": "E"}], "type": "letter", "published": "2020-10-00", "journal": {"title": "Dig Liver Dis", "issn": "1878-3562", "volume": "52", "issue": "10", "pages": "1099-1101", "issn-l": null}, "abstract": null, "doi": "10.1016/j.dld.2020.05.048", "pmid": "32571667", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1590-8658(20)30255-3"}, {"db": "pmc", "key": "PMC7304960"}], "notes": [], "created": "2020-12-08T16:28:21.367Z", "modified": "2020-12-08T16:28:21.390Z"}, {"entity": "publication", "iuid": "aace0e08aac84543b6d0633a82446ef2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aace0e08aac84543b6d0633a82446ef2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aace0e08aac84543b6d0633a82446ef2"}}, "title": "Pressure Optimized PowEred Respirator (PROPER): A miniaturized wearable cleanroom and biosafety system for aerially transmitted viral infections such as COVID-19.", "authors": [{"family": "Nazarious", "given": "Miracle Israel", "initials": "MI"}, {"family": "Mathanlal", "given": "Thasshwin", "initials": "T"}, {"family": "Zorzano", "given": "Maria-Paz", "initials": "MP"}, {"family": "Martin-Torres", "given": "Javier", "initials": "J"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "HardwareX", "issn": "2468-0672", "volume": "8", "issue": null, "pages": "e00144", "issn-l": null}, "abstract": "The supply of Personal Protective Equipment (PPE) in hospitals to keep the Health Care Professionals (HCP) safe taking care of patients may be limited, especially during the outbreak of a new disease. In particular, the face and body protective equipment is critical to prevent the wearer from exposure to pathogenic biological airborne particulates. This situation has been now observed worldwide during the onset of the COVID-19 pandemic. As concern over shortages of PPE at hospitals grows, we share with the public and makers' community the Pressure Optimized PowEred Respirator (PROPER) equipment, made out of COTS components. It is functionally equivalent to a Powered Air Purifying Respirator (PAPR). PROPER, a hood-based system which uses open source and easily accessible components is low-cost, relatively passive in terms of energy consumption and mechanisms, and easy and fast to 3D print, build and assemble. We have adapted our experience on building clean room environments and qualifying the bioburden of space instruments to this solution, which is in essence a miniaturized, personal, wearable cleanroom. PROPER would be able to offer better protection than an N95 respirator mask, mainly because it is insensitive to seal fit and it shields the eyes as well. The PROPER SMS fabric is designed for single-use and not intended for reuse, as they may start to tear and fail but the rest of the parts can be disinfected and reused. We provide a set of guidelines to build a low-cost 3D printed solution for an effective PAPR system and describe the procedures to validate it to comply with the biosafety level 3 requirements. We have validated the prototype of PROPER unit for air flow, ISO class cleanliness level, oxygen and carbon-dioxide gas concentrations during exhalation, and present here these results for illustration. We demonstrate that the area inside the hood is more than 200 times cleaner than the external ambient without the operator and more than 175 times with the operator and in an aerosol exposed environment. We also include the procedure to clean and disinfect the equipment for reuse. PROPER may be a useful addition to provide protection to HCPs against the SARS-CoV-2 virus or other potential future viral diseases that are transmitted aerially.", "doi": "10.1016/j.ohx.2020.e00144", "pmid": "33043172", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2468-0672(20)30053-5"}, {"db": "pmc", "key": "PMC7536593"}], "notes": [], "created": "2020-12-01T17:19:47.076Z", "modified": "2020-12-01T17:19:47.101Z"}, {"entity": "publication", "iuid": "7eac38cde76147eca0013d4c962fdd5e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7eac38cde76147eca0013d4c962fdd5e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7eac38cde76147eca0013d4c962fdd5e"}}, "title": "Physical activity during COVID-19 quarantine.", "authors": [{"family": "Shahidi", "given": "Seyed H", "initials": "SH"}, {"family": "Stewart Williams", "given": "Jennifer", "initials": "J"}, {"family": "Hassani", "given": "Fahimeh", "initials": "F"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": "109", "issue": "10", "pages": "2147-2148", "issn-l": "0803-5253"}, "abstract": null, "doi": "10.1111/apa.15420", "pmid": "32557827", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7323361"}], "notes": [], "created": "2020-12-09T07:45:52.698Z", "modified": "2020-12-09T07:46:00.446Z"}, {"entity": "publication", "iuid": "a6f02b3fa3814e92b4279055100a2c89", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6f02b3fa3814e92b4279055100a2c89.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6f02b3fa3814e92b4279055100a2c89"}}, "title": "Pediatric transplantation in Europe during the COVID-19 pandemic: Early impact on activity and healthcare.", "authors": [{"family": "Don\u00e1", "given": "Daniele", "initials": "D"}, {"family": "Torres Canizales", "given": "Juan", "initials": "J"}, {"family": "Benetti", "given": "Elisa", "initials": "E"}, {"family": "Cananzi", "given": "Mara", "initials": "M"}, {"family": "De Corti", "given": "Federica", "initials": "F"}, {"family": "Calore", "given": "Elisabetta", "initials": "E"}, {"family": "Hierro", "given": "Loreto", "initials": "L"}, {"family": "Ramos Boluda", "given": "Esther", "initials": "E"}, {"family": "Melgosa Hijosa", "given": "Marta", "initials": "M"}, {"family": "Garcia Guereta", "given": "Luis", "initials": "L"}, {"family": "P\u00e9rez Mart\u00ednez", "given": "Antonio", "initials": "A"}, {"family": "Barrios", "given": "Maribel", "initials": "M"}, {"family": "Costa Reis", "given": "Patricia", "initials": "P"}, {"family": "Teixeira", "given": "Ana", "initials": "A"}, {"family": "Lopes", "given": "Maria Francelina", "initials": "MF"}, {"family": "Kalici\u0144ski", "given": "Piotr", "initials": "P"}, {"family": "Branchereau", "given": "Sophie", "initials": "S"}, {"family": "Boyer", "given": "Olivia", "initials": "O"}, {"family": "Debray", "given": "Dominque", "initials": "D"}, {"family": "Sciveres", "given": "Marco", "initials": "M"}, {"family": "Wennberg", "given": "Lars", "initials": "L"}, {"family": "Fischler", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Barany", "given": "Peter", "initials": "P"}, {"family": "Baker", "given": "Alastair", "initials": "A"}, {"family": "Baumann", "given": "Ulrich", "initials": "U"}, {"family": "Schwerk", "given": "Nicolaus", "initials": "N"}, {"family": "Nicastro", "given": "Emanuele", "initials": "E"}, {"family": "Candusso", "given": "Manila", "initials": "M"}, {"family": "Toporski", "given": "Jacek", "initials": "J"}, {"family": "Sokal", "given": "Etienne", "initials": "E"}, {"family": "Stephenne", "given": "Xavier", "initials": "X"}, {"family": "Lindemans", "given": "Caroline", "initials": "C"}, {"family": "Miglinas", "given": "Marius", "initials": "M"}, {"family": "Rascon", "given": "Jelena", "initials": "J"}, {"family": "Jara", "given": "Paloma", "initials": "P"}, {"family": "ERN TransplantChild", "given": "", "initials": ""}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Clin Transplant", "issn": "1399-0012", "volume": "34", "issue": "10", "pages": "e14063", "issn-l": null}, "abstract": "The current pandemic SARS-CoV-2 has required an unusual allocation of resources that can negatively impact chronically ill patients and high-complexity procedures. Across the European Reference Network on Pediatric Transplantation (ERN TransplantChild), we conducted a survey to investigate the impact of the COVID-19 outbreak on pediatric transplant activity and healthcare practices in both solid organ transplantation (SOT) and hematopoietic stem cell transplantation (HSCT). The replies of 30 professionals from 18 centers in Europe were collected. Twelve of 18 centers (67%) showed a reduction in their usual transplant activity. Additionally, outpatient visits have been modified and restricted to selected ones, and the use of telemedicine tools has increased. Additionally, a total of 14 COVID-19 pediatric transplanted patients were identified at the time of the survey, including eight transplant recipients and six candidates for transplantation. Only two moderate-severe cases were reported, both in HSCT setting. These survey results demonstrate the limitations in healthcare resources for pediatric transplantation patients during early stages of this pandemic. COVID-19 disease is a major worldwide challenge for the field of pediatric transplantation, where there will be a need for systematic data collection, encouraging regular discussions to address the long-term consequences for pediatric transplantation candidates, recipients, and their families.", "doi": "10.1111/ctr.14063", "pmid": "32786120", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7435500"}], "notes": [], "created": "2020-12-07T13:28:32.289Z", "modified": "2020-12-07T13:28:32.314Z"}, {"entity": "publication", "iuid": "04e4c4b436a346d5aab70592cfa88caf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/04e4c4b436a346d5aab70592cfa88caf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/04e4c4b436a346d5aab70592cfa88caf"}}, "title": "Pathophysiology of the COVID-19 - entry to the CNS through the nose.", "authors": [{"family": "Ylikoski", "given": "Jukka", "initials": "J"}, {"family": "Markkanen", "given": "Marika", "initials": "M"}, {"family": "M\u00e4kitie", "given": "Antti", "initials": "A"}], "type": "editorial", "published": "2020-10-00", "journal": {"title": "Acta Otolaryngol", "issn": "1651-2251", "volume": "140", "issue": "10", "pages": "886-889", "issn-l": "0001-6489"}, "abstract": null, "doi": "10.1080/00016489.2020.1773533", "pmid": "32597276", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-26T12:25:16.279Z", "modified": "2020-11-30T08:54:52.911Z"}, {"entity": "publication", "iuid": "96b0715e8c8b4184a63d7666de8d709d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/96b0715e8c8b4184a63d7666de8d709d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/96b0715e8c8b4184a63d7666de8d709d"}}, "title": "Paediatric COVID-19 admissions in a region with open schools during the two first months of the pandemic.", "authors": [{"family": "Hildenwall", "given": "Helena", "initials": "H"}, {"family": "Luthander", "given": "Joachim", "initials": "J"}, {"family": "Rhedin", "given": "Samuel", "initials": "S"}, {"family": "Hertting", "given": "Olof", "initials": "O"}, {"family": "Olsson-\u00c5kefeldt", "given": "Selma", "initials": "S"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Alfv\u00e9n", "given": "Tobias", "initials": "T"}, {"family": "Herlenius", "given": "Eric", "initials": "E"}, {"family": "Ryd Rinder", "given": "Malin", "initials": "M"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": "109", "issue": "10", "pages": "2152-2154", "issn-l": "0803-5253"}, "abstract": null, "doi": "10.1111/apa.15432", "pmid": "32567145", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7323214"}], "notes": [], "created": "2020-12-08T16:30:28.877Z", "modified": "2021-02-26T08:45:48.478Z"}, {"entity": "publication", "iuid": "8a9af387c8834711aab4872a8c36a9e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a9af387c8834711aab4872a8c36a9e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a9af387c8834711aab4872a8c36a9e7"}}, "title": "Open synthesis and the coronavirus pandemic in 2020.", "authors": [{"family": "Haddaway", "given": "Neal R", "initials": "NR"}, {"family": "Akl", "given": "Elie A", "initials": "EA"}, {"family": "Page", "given": "Matthew J", "initials": "MJ"}, {"family": "Welch", "given": "Vivian A", "initials": "VA"}, {"family": "Keenan", "given": "Ciara", "initials": "C"}, {"family": "Lotfi", "given": "Tamara", "initials": "T"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "J Clin Epidemiol", "issn": "1878-5921", "volume": "126", "issue": null, "pages": "184-191", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jclinepi.2020.06.032", "pmid": "32621854", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0895-4356(20)30461-3"}, {"db": "pmc", "key": "PMC7328560"}], "notes": [], "created": "2020-11-30T08:51:27.807Z", "modified": "2020-11-30T08:51:27.832Z"}, {"entity": "publication", "iuid": "c416ec4ee19a4167910ae1f8f02cc9a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c416ec4ee19a4167910ae1f8f02cc9a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c416ec4ee19a4167910ae1f8f02cc9a6"}}, "title": "No small matter: a perspective on nanotechnology-enabled solutions to fight COVID-19.", "authors": [{"family": "Jones", "given": "Georgia Wilson", "initials": "GW"}, {"family": "Monopoli", "given": "Marco P", "initials": "MP"}, {"family": "Campagnolo", "given": "Luisa", "initials": "L"}, {"family": "Pietroiusti", "given": "Antonio", "initials": "A"}, {"family": "Tran", "given": "Lang", "initials": "L"}, {"family": "Fadeel", "given": "Bengt", "initials": "B"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Nanomedicine (Lond)", "issn": "1748-6963", "volume": "15", "issue": "24", "pages": "2411-2427", "issn-l": null}, "abstract": "There is an urgent need for safe and effective approaches to combat COVID-19. Here, we asked whether lessons learned from nanotoxicology and nanomedicine could shed light on the current pandemic. SARS-CoV-2, the causative agent, may trigger a mild, self-limiting disease with respiratory symptoms, but patients may also succumb to a life-threatening systemic disease. The host response to the virus is equally complex and studies are now beginning to unravel the immunological correlates of COVID-19. Nanotechnology can be applied for the delivery of antiviral drugs or other repurposed drugs. Moreover, recent work has shown that synthetic nanoparticles wrapped with host-derived cellular membranes may prevent virus infection. We posit that nanoparticles decorated with ACE2, the receptor for SARS-CoV-2, could be exploited as decoys to intercept the virus before it infects cells in the respiratory tract. However, close attention should be paid to biocompatibility before such nano-decoys are deployed in the clinic.", "doi": "10.2217/nnm-2020-0286", "pmid": "32873192", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7488724"}], "notes": [], "created": "2020-12-06T07:36:25.377Z", "modified": "2020-12-06T07:36:25.402Z"}, {"entity": "publication", "iuid": "59b00923374e47adbc0f1d94c7e13e40", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/59b00923374e47adbc0f1d94c7e13e40.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/59b00923374e47adbc0f1d94c7e13e40"}}, "title": "Neurological manifestations of coronavirus infections - a systematic review.", "authors": [{"family": "Almqvist", "given": "Jesper", "initials": "J"}, {"family": "Granberg", "given": "Tobias", "initials": "T"}, {"family": "Tzortzakakis", "given": "Antonios", "initials": "A"}, {"family": "Klironomos", "given": "Stefanos", "initials": "S"}, {"family": "Kollia", "given": "Evangelia", "initials": "E"}, {"family": "\u00d6hberg", "given": "Claes", "initials": "C"}, {"family": "Martin", "given": "Roland", "initials": "R"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Ouellette", "given": "Russell", "initials": "R"}, {"family": "Ineichen", "given": "Benjamin V", "initials": "BV"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Ann Clin Transl Neurol", "issn": "2328-9503", "volume": "7", "issue": "10", "pages": "2057-2071", "issn-l": "2328-9503"}, "abstract": "To optimize diagnostic workup of the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, we systematically reviewed neurological and neuroradiological manifestations of SARS-CoV-2 and all other known human coronavirus species (HCoV). Which lessons can we learn? We identified relevant publications (until 26 July 2020) using systematic searches in PubMed, Web of Science, and Ovid EMBASE with predefined search strings. A total of 4571 unique publications were retrieved, out of which 378 publications were selected for in-depth analysis by two raters, including a total of 17549 (out of which were 14418 SARS-CoV-2) patients. Neurological complications and associated neuroradiological manifestations are prevalent for all HCoVs (HCoV-229E, HKU1, NL63, OC43, Middle East respiratory syndrome (MERS)-CoV, SARS-CoV-1, and SARS-CoV-2). Moreover there are similarities in symptomatology across different HCoVs, particularly between SARS-CoV-1 and SARS-CoV-2. Common neurological manifestations include fatigue, headache, and smell/taste disorders. Additionally, clinicians need to be attentive for at least five classes of neurological complications: (1) Cerebrovascular disorders including ischemic stroke and macro/micro-hemorrhages, (2) encephalopathies, (3) para-/postinfectious immune-mediated complications such as Guillain-Barr\u00e9 syndrome and acute disseminated encephalomyelitis, (4) (meningo-)encephalitis, potentially with concomitant seizures, and (5) neuropsychiatric complications such as psychosis and mood disorders. Our systematic review highlights the need for vigilance regarding neurological complications in patients infected by SARS-CoV-2 and other HCoVs, especially since some complications may result in chronic disability. Neuroimaging protocols should be designed to specifically screen for these complications. Therefore, we propose practical imaging guidelines to facilitate the diagnostic workup and monitoring of patients infected with HCoVs.", "doi": "10.1002/acn3.51166", "pmid": "32853453", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7461163"}], "notes": [], "created": "2020-11-26T12:17:30.281Z", "modified": "2020-11-30T08:36:35.331Z"}, {"entity": "publication", "iuid": "442c80b494834398a3e3d3882c5ea990", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/442c80b494834398a3e3d3882c5ea990.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/442c80b494834398a3e3d3882c5ea990"}}, "title": "Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia (COVID STEROID) trial-Protocol and statistical analysis plan.", "authors": [{"family": "Petersen", "given": "Marie Warrer", "initials": "MW"}, {"family": "Meyhoff", "given": "Tine Sylvest", "initials": "TS"}, {"family": "Helleberg", "given": "Marie", "initials": "M"}, {"family": "Kjaer", "given": "Maj-Brit N\u00f8rregaard", "initials": "MN"}, {"family": "Granholm", "given": "Anders", "initials": "A"}, {"family": "Hjorts\u00f8", "given": "Carl Johan Steensen", "initials": "CJS"}, {"family": "Jensen", "given": "Thomas Steen", "initials": "TS"}, {"family": "M\u00f8ller", "given": "Morten Hylander", "initials": "MH"}, {"family": "Hjortrup", "given": "Peter Buhl", "initials": "PB"}, {"family": "Wetterslev", "given": "Mik", "initials": "M"}, {"family": "Vesterlund", "given": "Gitte Kingo", "initials": "GK"}, {"family": "Russell", "given": "Lene", "initials": "L"}, {"family": "J\u00f8rgensen", "given": "Vibeke Lind", "initials": "VL"}, {"family": "Tjelle", "given": "Klaus", "initials": "K"}, {"family": "Benfield", "given": "Thomas", "initials": "T"}, {"family": "Ulrik", "given": "Charlotte Suppli", "initials": "CS"}, {"family": "Andreasen", "given": "Anne Sofie", "initials": "AS"}, {"family": "Mohr", "given": "Thomas", "initials": "T"}, {"family": "Bestle", "given": "Morten H", "initials": "MH"}, {"family": "Poulsen", "given": "Lone Musaeus", "initials": "LM"}, {"family": "Hitz", "given": "Mette Friberg", "initials": "MF"}, {"family": "Hildebrandt", "given": "Thomas", "initials": "T"}, {"family": "Knudsen", "given": "Lene Surland", "initials": "LS"}, {"family": "M\u00f8ller", "given": "Anders", "initials": "A"}, {"family": "S\u00f8lling", "given": "Christoffer Grant", "initials": "CG"}, {"family": "Br\u00f8chner", "given": "Anne Craveiro", "initials": "AC"}, {"family": "Rasmussen", "given": "Bodil Steen", "initials": "BS"}, {"family": "Nielsen", "given": "Henrik", "initials": "H"}, {"family": "Christensen", "given": "Steffen", "initials": "S"}, {"family": "Str\u00f8m", "given": "Thomas", "initials": "T"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Wahlin", "given": "Rebecka Rubenson", "initials": "RR"}, {"family": "Jakob", "given": "Stephan", "initials": "S"}, {"family": "Cioccari", "given": "Luca", "initials": "L"}, {"family": "Venkatesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Hammond", "given": "Naomi", "initials": "N"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Myatra", "given": "Sheila Nainan", "initials": "SN"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Lange", "given": "Theis", "initials": "T"}, {"family": "Perner", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "volume": "64", "issue": "9", "pages": "1365-1375", "issn-l": "0001-5172"}, "abstract": "Severe acute respiratory syndrome coronavirus-2 has caused a pandemic of coronavirus disease (COVID-19) with many patients developing hypoxic respiratory failure. Corticosteroids reduce the time on mechanical ventilation, length of stay in the intensive care unit and potentially also mortality in similar patient populations. However, corticosteroids have undesirable effects, including longer time to viral clearance. Clinical equipoise on the use of corticosteroids for COVID-19 exists.\n\nThe COVID STEROID trial is an international, randomised, stratified, blinded clinical trial. We will allocate 1000 adult patients with COVID-19 receiving \u226510 L/min of oxygen or on mechanical ventilation to intravenous hydrocortisone 200 mg daily vs placebo (0.9% saline) for 7 days. The primary outcome is days alive without life support (ie mechanical ventilation, circulatory support, and renal replacement therapy) at day 28. Secondary outcomes are serious adverse reactions at day 14; days alive without life support at day 90; days alive and out of hospital at day 90; all-cause mortality at day 28, day 90, and 1 year; and health-related quality of life at 1 year. We will conduct the statistical analyses according to this protocol, including interim analyses for every 250 patients followed for 28 days. The primary outcome will be compared using the Kryger Jensen and Lange test in the intention to treat population and reported as differences in means and medians with 95% confidence intervals.\n\nThe COVID STEROID trial will provide important evidence to guide the use of corticosteroids in COVID-19 and severe hypoxia.", "doi": "10.1111/aas.13673", "pmid": "32779728", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7404666"}], "notes": [], "created": "2020-12-07T13:32:20.495Z", "modified": "2021-02-26T08:45:48.099Z"}, {"entity": "publication", "iuid": "b1323021dc7d45f6b4afca061534617c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1323021dc7d45f6b4afca061534617c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1323021dc7d45f6b4afca061534617c"}}, "title": "Long-term consequences of COVID-19: research needs.", "authors": [{"family": "Yelin", "given": "Dana", "initials": "D"}, {"family": "Wirtheim", "given": "Eytan", "initials": "E"}, {"family": "Vetter", "given": "Pauline", "initials": "P"}, {"family": "Kalil", "given": "Andre C", "initials": "AC"}, {"family": "Bruchfeld", "given": "Judith", "initials": "J"}, {"family": "Runold", "given": "Michael", "initials": "M"}, {"family": "Guaraldi", "given": "Giovanni", "initials": "G"}, {"family": "Mussini", "given": "Cristina", "initials": "C"}, {"family": "Gudiol", "given": "Carlota", "initials": "C"}, {"family": "Pujol", "given": "Miquel", "initials": "M"}, {"family": "Bandera", "given": "Alessandra", "initials": "A"}, {"family": "Scudeller", "given": "Luigia", "initials": "L"}, {"family": "Paul", "given": "Mical", "initials": "M"}, {"family": "Kaiser", "given": "Laurent", "initials": "L"}, {"family": "Leibovici", "given": "Leonard", "initials": "L"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "volume": "20", "issue": "10", "pages": "1115-1117", "issn-l": null}, "abstract": null, "doi": "10.1016/S1473-3099(20)30701-5", "pmid": "32888409", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(20)30701-5"}, {"db": "pmc", "key": "PMC7462626"}], "notes": [], "created": "2020-12-06T07:25:57.455Z", "modified": "2020-12-06T07:26:37.438Z"}, {"entity": "publication", "iuid": "15e7e3fed3654797aae82e30150d72d6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15e7e3fed3654797aae82e30150d72d6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15e7e3fed3654797aae82e30150d72d6"}}, "title": "Laser irradiated phenothiazines: New potential treatment for COVID-19 explored by molecular docking.", "authors": [{"family": "Udrea", "given": "Ana-Maria", "initials": "AM"}, {"family": "Avram", "given": "Speranta", "initials": "S"}, {"family": "Nistorescu", "given": "Simona", "initials": "S"}, {"family": "Pascu", "given": "Mihail-Lucian", "initials": "ML"}, {"family": "Romanitan", "given": "Mihaela Oana", "initials": "MO"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "J Photochem Photobiol B", "issn": "1873-2682", "volume": "211", "issue": null, "pages": "111997", "issn-l": null}, "abstract": "The worldwide infection with the new Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) demands urgently new potent treatment(s). In this study we predict, using molecular docking, the binding affinity of 15 phenothiazines (antihistaminic and antipsychotic drugs) when interacting with the main protease (M pro) of SARS-CoV-2. Additionally, we tested the binding affinity of photoproducts identified after irradiation of phenothiazines with Nd:YAG laser beam at 266 nm respectively 355 nm. Our results reveal that thioridazine and its identified photoproducts (mesoridazine and sulforidazine) have high biological activity on the virus Mpro. This shows that thioridazine and its two photoproducts might represent new potent medicines to be used for treatment in this outbreak. Such results recommend these medicines for further tests on cell cultures infected with SARS-CoV-2 or animal model. The transition to human subjects of the suggested treatment will be smooth due to the fact that the drugs are already available on the market.", "doi": "10.1016/j.jphotobiol.2020.111997", "pmid": "32829256", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S1011-1344(20)30447-4"}, {"db": "pmc", "key": "PMC7428740"}], "notes": [], "created": "2020-12-07T11:46:08.690Z", "modified": "2021-02-26T08:45:02.860Z"}, {"entity": "publication", "iuid": "b630793a5e87457eaa2ed82dc2b65c38", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b630793a5e87457eaa2ed82dc2b65c38.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b630793a5e87457eaa2ed82dc2b65c38"}}, "title": "Is COVID-19 associated thrombosis caused by overactivation of the complement cascade? A literature review.", "authors": [{"family": "Fletcher-Sandersj\u00f6\u00f6", "given": "Alexander", "initials": "A"}, {"family": "Bellander", "given": "Bo-Michael", "initials": "BM"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Thromb Res", "issn": "1879-2472", "volume": "194", "issue": null, "pages": "36-41", "issn-l": "0049-3848"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 is responsible for the current COVID-19 pandemic resulting in an escalating number of cases and fatalities worldwide. Preliminary evidence from these patients, as well as past coronavirus epidemics, indicates that those infected suffer from disproportionate complement activation as well as excessive coagulation, leading to thrombotic complications and poor outcome. In non-coronavirus cohorts, evidence has accumulated of an interaction between the complement and coagulation systems, with one amplifying activation of the other. A pressing question is therefore if COVID-19 associated thrombosis could be caused by overactivation of the complement cascade? In this review, we summarize the literature on thrombotic complications in COVID-19, complement activation in coronavirus infections, and the crosstalk between the complement and coagulation systems. We demonstrate how the complement system is able to activate the coagulation cascade and platelets, inhibit fibrinolysis and stimulate endothelial cells. We also describe how these interactions see clinical relevance in several disorders where overactive complement results in a prothrombotic clinical presentation, and how it could be clinically relevant in COVID-19.", "doi": "10.1016/j.thromres.2020.06.027", "pmid": "32569879", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0049-3848(20)30269-3"}, {"db": "pmc", "key": "PMC7301826"}], "notes": [], "created": "2020-11-26T12:14:19.289Z", "modified": "2020-11-30T08:59:18.013Z"}, {"entity": "publication", "iuid": "6ac2ef0d1f96420ba6da209a41beff4b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ac2ef0d1f96420ba6da209a41beff4b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ac2ef0d1f96420ba6da209a41beff4b"}}, "title": "Invasive mechanical ventilation in a former preterm infant with COVID-19.", "authors": [{"family": "Nyholm", "given": "Silvia", "initials": "S"}, {"family": "Edner", "given": "Ann", "initials": "A"}, {"family": "Myrelid", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Janols", "given": "Helena", "initials": "H"}, {"family": "D\u00f6renberg", "given": "Rainer", "initials": "R"}, {"family": "Diderholm", "given": "Barbro", "initials": "B"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": "109", "issue": "10", "pages": "2141-2143", "issn-l": "0803-5253"}, "abstract": null, "doi": "10.1111/apa.15437", "pmid": "32569422", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7361564"}], "notes": [], "created": "2020-12-08T16:28:27.718Z", "modified": "2020-12-08T16:28:27.730Z"}, {"entity": "publication", "iuid": "6ebda7bd436a47428776a6a0d65f6831", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ebda7bd436a47428776a6a0d65f6831.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ebda7bd436a47428776a6a0d65f6831"}}, "title": "Interventions to Reduce Aerosolized Microbes in Dental Practice: A Systematic Review with Network Meta-analysis of Randomized Controlled Trials.", "authors": [{"family": "Koletsi", "given": "D", "initials": "D"}, {"family": "Belibasakis", "given": "G N", "initials": "GN"}, {"family": "Eliades", "given": "T", "initials": "T"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "J Dent Res", "issn": "1544-0591", "volume": "99", "issue": "11", "pages": "1228-1238", "issn-l": "0022-0345"}, "abstract": "The aim of this systematic review and network meta-analysis was to identify and rank the effectiveness of different interventions used in dental practice to reduce microbial load in aerosolized compounds. Seven electronic databases were searched to April 6, 2020, for randomized controlled trials (RCTs) or nonrandomized prospective studies in the field. Study selection, data extraction, and risk-of-bias assessment were performed for all included studies, while the outcome of interest pertained to differences in bacterial load quantification through the use of different interventions prior to aerosol-generating procedures in dental practices. Random effects frequentist network meta-analysis was performed, with mean difference (MD) and 95% CI as the effect measure. Confidence in the documented evidence was assessed through the newly fueled CINeMA framework (Confidence in Network Meta-analysis) based on the GRADE approach (Grading of Recommendations, Assessment, Development and Evaluation). Twenty-nine clinical trials were deemed eligible, 21 RCTs and 8 nonrandomized studies, while 11 RCTs contributed to the network meta-analysis, comprising 10 competing interventions. Tempered chlorhexidine (CHX) 0.2% as compared with nonactive control mouth rinse, prior to routine ultrasonic scaling, was most effective toward reduced postprocedural bacterial load with an MD of -0.92 (95% CI, -1.54 to -0.29) in log 10 bacterial CFUs (colony-forming units). For CHX 0.2%, an MD of -0.74 (95% CI, -1.07 to -0.40) was observed as compared with control. Tempered CHX 0.2% presented the highest probabilities of being ranked the most effective treatment (31.2%). Level of confidence varied from very low to moderate across all formulated comparisons. These findings summarize the current state of research evidence in the field of aerosolized bacteria in dentistry. Instigated by the era of SARS-CoV-2 pandemic, the stipulation of a broader evaluation of the aerosolized microbes, including viruses, potentially coupled with disinfectant-based prevention schemes should be prioritized.", "doi": "10.1177/0022034520943574", "pmid": "32660314", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-26T12:20:02.782Z", "modified": "2020-11-30T08:51:23.085Z"}, {"entity": "publication", "iuid": "8043a8d98fa242cfa5e92cf1d93b58b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8043a8d98fa242cfa5e92cf1d93b58b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8043a8d98fa242cfa5e92cf1d93b58b2"}}, "title": "Increasing maternal mortality associated with COVID-19 and shortage of intensive care is a serious concern in low-resource settings.", "authors": [{"family": "Silveira Campos", "given": "Luciana", "initials": "L"}, {"family": "Peixoto Caldas", "given": "Jos\u00e9 M", "initials": "JM"}], "type": "letter", "published": "2020-10-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "10", "pages": "1421", "issn-l": "0001-6349"}, "abstract": null, "doi": "10.1111/aogs.13975", "pmid": "32799338", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7461434"}], "notes": [], "created": "2020-12-07T13:22:08.337Z", "modified": "2020-12-07T13:22:08.347Z"}, {"entity": "publication", "iuid": "3c78deda48504db9a8f995bd38917104", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3c78deda48504db9a8f995bd38917104.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3c78deda48504db9a8f995bd38917104"}}, "title": "In silico Potential of Approved Antimalarial Drugs for Repurposing Against COVID-19.", "authors": [{"family": "Sachdeva", "given": "Cheryl", "initials": "C"}, {"family": "Wadhwa", "given": "Anju", "initials": "A"}, {"family": "Kumari", "given": "Anita", "initials": "A"}, {"family": "Hussain", "given": "Firasat", "initials": "F"}, {"family": "Jha", "given": "Preeti", "initials": "P"}, {"family": "Kaushik", "given": "Naveen K", "initials": "NK"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "OMICS", "issn": "1557-8100", "volume": "24", "issue": "10", "pages": "568-580", "issn-l": "1536-2310"}, "abstract": "Although the coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is wreaking havoc and resulting in mortality and morbidity across the planet, novel treatments are urgently needed. Drug repurposing offers an innovative approach in this context. We report here new findings on the in silico potential of several antimalarial drugs for repurposing against COVID-19. We conducted analyses by docking the compounds against two SARS-CoV-2-specific targets: (1) the receptor binding domain spike protein and (2) the main protease of the virus (MPro) using the Schr\u00f6dinger software. Importantly, the docking analysis revealed that doxycycline (DOX) showed the most effective binding to the spike protein of SARS-CoV-2, whereas halofantrine and mefloquine bound effectively with the main protease among the antimalarial drugs evaluated in the present study. The in silico approach reported here suggested that DOX could potentially be a good candidate for repurposing for COVID-19. In contrast, to decipher the actual potential of DOX and halofantrine against COVID-19, further in vitro and in vivo studies are called for. Drug repurposing warrants consideration as a viable research and innovation avenue as planetary health efforts to fight the COVID-19 continue.", "doi": "10.1089/omi.2020.0071", "pmid": "32757981", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2020-11-19T14:41:00.439Z", "modified": "2021-02-26T08:45:02.956Z"}, {"entity": "publication", "iuid": "ee6cb4249076448a8c69ea2732de3566", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee6cb4249076448a8c69ea2732de3566.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee6cb4249076448a8c69ea2732de3566"}}, "title": "High excess mortality in areas with young and socially vulnerable populations during the COVID-19 outbreak in Stockholm Region, Sweden.", "authors": [{"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A", "orcid": "0000-0001-9064-9222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/166407b0da5346b3aef841949b0212da.json"}}, {"family": "Vetrano", "given": "Davide L", "initials": "DL"}, {"family": "Rizzuto", "given": "Debora", "initials": "D"}, {"family": "Bellander", "given": "Tom", "initials": "T"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Dekhtyar", "given": "Serhiy", "initials": "S"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "issn-l": "2059-7908", "volume": "5", "issue": "10", "pages": "e003595"}, "abstract": "We aimed to describe the distribution of excess mortality (EM) during the first weeks of the COVID-19 outbreak in the Stockholm Region, Sweden, according to age, sex and sociodemographic context.\n\nWeekly all-cause mortality data were obtained from Statistics Sweden for the period 1 January 2015 to 17 May 2020. EM during the first 20 weeks of 2020 was estimated by comparing observed mortality rates with expected mortality rates during the five previous years (N=2 379 792). EM variation by socioeconomic status (tertiles of income, education, Swedish-born, gainful employment) and age distribution (share of 70+-year-old persons) was explored based on Demographic Statistics Area (DeSO) data.\n\nEM was first detected during the week of 23-29 March 2020. During the peak week of the epidemic (6-12 April 2020), an EM of 150% was observed (152% in 80+-year-old women; 183% in 80+-year-old men). During the same week, the highest EM was observed for DeSOs with lowest income (171%), lowest education (162%), lowest share of Swedish-born (178%) and lowest share of gainfully employed residents (174%). EM was further increased in areas with higher versus lower proportion of younger people (magnitude of increase: 1.2-1.7 times depending on socioeconomic measure).\n\nLiving in areas characterised by lower socioeconomic status and younger populations was linked to excess mortality during the COVID-19 pandemic in the Stockholm Region. These conditions might have facilitated viral spread. Our findings highlight the well-documented vulnerability linked to increasing age and sociodemographic context for COVID-19-related death.", "doi": "10.1136/bmjgh-2020-003595", "pmid": "33109636", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7592025"}, {"db": "pii", "key": "bmjgh-2020-003595"}], "notes": [], "created": "2020-11-27T10:24:44.096Z", "modified": "2023-06-19T15:28:44.800Z"}, {"entity": "publication", "iuid": "e4d57f90525b4263818c08975dabc530", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e4d57f90525b4263818c08975dabc530.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e4d57f90525b4263818c08975dabc530"}}, "title": "Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes.", "authors": [{"family": "Robinson", "given": "Emma L", "initials": "EL"}, {"family": "Alkass", "given": "Kanar", "initials": "K"}, {"family": "Bergmann", "given": "Olaf", "initials": "O"}, {"family": "Maguire", "given": "Janet J", "initials": "JJ"}, {"family": "Roderick", "given": "H Llewelyn", "initials": "HL"}, {"family": "Davenport", "given": "Anthony P", "initials": "AP"}], "type": "letter", "published": "2020-10-00", "journal": {"title": "J Mol Cell Cardiol", "issn": "1095-8584", "volume": "147", "issue": null, "pages": "88-91", "issn-l": null}, "abstract": null, "doi": "10.1016/j.yjmcc.2020.08.009", "pmid": "32818486", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0022-2828(20)30257-1"}, {"db": "pmc", "key": "PMC7431326"}], "notes": [], "created": "2020-12-07T12:24:07.369Z", "modified": "2021-02-26T08:45:48.812Z"}, {"entity": "publication", "iuid": "1d34fda32e3344aca9277e9b656cbcb2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d34fda32e3344aca9277e9b656cbcb2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d34fda32e3344aca9277e9b656cbcb2"}}, "title": "Future liasing of the lockdown during COVID-19 pandemic: The dawn is expected at hand from the darkest hour.", "authors": [{"family": "Khursheed", "given": "Anwar", "initials": "A"}, {"family": "Alam", "given": "Shamshad", "initials": "S"}, {"family": "Tyagi", "given": "Vinay Kumar", "initials": "VK"}, {"family": "Nagpure", "given": "Ajay S", "initials": "AS"}, {"family": "Khan", "given": "Abid Ali", "initials": "AA"}, {"family": "Gaur", "given": "Rubia Z", "initials": "RZ"}, {"family": "Singh", "given": "Sanyogita", "initials": "S"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Mukherjee", "given": "Santanu", "initials": "S"}, {"family": "Kumar", "given": "Manish", "initials": "M"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Groundw Sustain Dev", "issn": "2352-801X", "volume": "11", "issue": null, "pages": "100433", "issn-l": null}, "abstract": "The lockdown during COVID-19 pandemic has converted the world into new experimental laboratories, which may reveal temporal or spatial comparative analysis data. However, some startling information is gathered in terms of reduced premature mortality cases associated with air and water quality improvement, enhanced e-learning on a broader platform, work from home, and successful e-health. The decline in vehicular density on roads and congestion leads to reduced energy consumption and associated greenhouse gases (GHG) and other pollutants emission. The lockdown has also been identified as a possible emergency measure to combat severe air pollution episodes. Similarly, industrial pollution has been recognized as one of the primary causes of water resource pollution and would, therefore, bring change in policy vis-\u00e0-vis groundwater pollution control. Our findings suggest that the results of successful e-learning and work from home would be a permanent shift from conventional modes in the near future due to a drastic reduction in socio-economic cost. Our critical analysis also highlights that with such temporary lockdown measures acute/chronic ill-effects of anthropogenic perturbations on planet earth can be effectively estimated through sociocultural, socioeconomical and socio-political/sociotechnological nexus.", "doi": "10.1016/j.gsd.2020.100433", "pmid": "32835071", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2352-801X(20)30268-X"}, {"db": "pii", "key": "100433"}, {"db": "pmc", "key": "PMC7319642"}], "notes": [], "created": "2020-12-07T11:44:03.369Z", "modified": "2020-12-07T11:44:03.393Z"}, {"entity": "publication", "iuid": "ce1eb385f7aa43f881128314a8d2ae21", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ce1eb385f7aa43f881128314a8d2ae21.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ce1eb385f7aa43f881128314a8d2ae21"}}, "title": "Forgotten Technology in the COVID-19 Pandemic: Filtration Properties of Cloth and Cloth Masks-A Narrative Review.", "authors": [{"family": "Clase", "given": "Catherine M", "initials": "CM"}, {"family": "Fu", "given": "Edouard L", "initials": "EL"}, {"family": "Ashur", "given": "Aurneen", "initials": "A"}, {"family": "Beale", "given": "Rupert C L", "initials": "RCL"}, {"family": "Clase", "given": "Imogen A", "initials": "IA"}, {"family": "Dolovich", "given": "Myrna B", "initials": "MB"}, {"family": "Jardine", "given": "Meg J", "initials": "MJ"}, {"family": "Joseph", "given": "Meera", "initials": "M"}, {"family": "Kansiime", "given": "Grace", "initials": "G"}, {"family": "Mann", "given": "Johannes F E", "initials": "JFE"}, {"family": "Pecoits-Filho", "given": "Roberto", "initials": "R"}, {"family": "Winkelmayer", "given": "Wolfgang C", "initials": "WC"}, {"family": "Carrero", "given": "Juan J", "initials": "JJ"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Mayo Clin Proc", "issn": "1942-5546", "volume": "95", "issue": "10", "pages": "2204-2224", "issn-l": "0025-6196"}, "abstract": "Management of the global crisis of the coronavirus disease 2019 pandemic requires detailed appraisal of evidence to support clear, actionable, and consistent public health messaging. The use of cloth masks for general public use is being debated, and is in flux. We searched the MEDLINE and EMBASE databases and Google for articles reporting the filtration properties of flat cloth or cloth masks. We reviewed the reference lists of relevant articles to identify further articles and identified articles through social and conventional news media. We found 25 articles. Study of protection for the wearer used healthy volunteers, or used a manikin wearing a mask, with airflow to simulate different breathing rates. Studies of protection of the environment, also known as source control, used convenience samples of healthy volunteers. The design and execution of the studies was generally rigorously described. Many descriptions of cloth lacked the detail required for reproducibility; no study provided all the expected details of material, thread count, weave, and weight. Some of the homemade mask designs were reproducible. Successful masks were made of muslin at 100 threads per inch (TPI) in 3 to 4 layers (4-layer muslin or a muslin-flannel-muslin sandwich), tea towels (also known as dish towels), made using 1 layer (2 layers would be expected to be better), and good-quality cotton T-shirts in 2 layers (with a stitched edge to prevent stretching). In flat-cloth experiments, linen tea towels, 600-TPI cotton in 2 layers, and 600-TPI cotton with 90-TPI flannel performed well but 80-TPI cotton in 2 layers did not. We therefore recommend cotton or flannel at least 100 TPI, at least 2 layers. More layers, 3 or 4, will provide increased filtration but there is a trade-off in that more layers increases the resistance to breathing. Although this is not a systematic review, we included all the articles that we identified in an unbiased way. We did not include gray literature or preprints. A plain language summary of these data and recommendations, as well as information on making, wearing and cleaning cloth masks is available at www.clothmasks.ca.", "doi": "10.1016/j.mayocp.2020.07.020", "pmid": "33012350", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0025-6196(20)30826-0"}], "notes": [], "created": "2020-11-26T12:30:06.960Z", "modified": "2020-11-26T12:30:06.978Z"}, {"entity": "publication", "iuid": "4e6914020d7d475d935aa1ca7e8a49e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4e6914020d7d475d935aa1ca7e8a49e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4e6914020d7d475d935aa1ca7e8a49e7"}}, "title": "Existing highly accumulating lysosomotropic drugs with potential for repurposing to target COVID-19.", "authors": [{"family": "Norinder", "given": "Ulf", "initials": "U"}, {"family": "Tuck", "given": "Astrud", "initials": "A"}, {"family": "Norgren", "given": "Kalle", "initials": "K"}, {"family": "Munic Kos", "given": "Vesna", "initials": "V"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Biomed Pharmacother", "issn": "1950-6007", "volume": "130", "issue": null, "pages": "110582", "issn-l": "0753-3322"}, "abstract": "Given the speed of viral infection spread, repurposing of existing drugs has been given the highest priority in combating the ongoing COVID-19 pandemic. Only drugs that are already registered or close to registration, and therefore have passed lengthy safety assessments, have a chance to be tested in clinical trials and reach patients quickly enough to help in the current disease outbreak. Here, we have reviewed available evidence and possible ways forward to identify already existing pharmaceuticals displaying modest broad-spectrum antiviral activity which is likely linked to their high accumulation in cells. Several well studied examples indicate that these drugs accumulate in lysosomes, endosomes and biological membranes in general, and thereby interfere with endosomal pathway and intracellular membrane trafficking crucial for viral infection. With the aim to identify other lysosomotropic drugs with possible inherent antiviral activity, we have applied a set of clear physicochemical, pharmacokinetic and molecular criteria on 530 existing drugs. In addition to publicly available data, we have also used our in silico model for the prediction of accumulation in lysosomes and endosomes. By this approach we have identified 36 compounds with possible antiviral effects, also against coronaviruses. For 14 of them evidence of broad-spectrum antiviral activity has already been reported, adding support to the value of this approach. Presented pros and cons, knowledge gaps and methods to identify lysosomotropic antivirals, can help in the evaluation of many drugs currently in clinical trials considered for repurposing to target COVID-19, as well as open doors to finding more potent and safer alternatives.", "doi": "10.1016/j.biopha.2020.110582", "pmid": "32763818", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0753-3322(20)30775-7"}, {"db": "pmc", "key": "PMC7392152"}], "notes": [], "created": "2020-11-26T12:31:26.600Z", "modified": "2020-11-30T08:42:55.516Z"}, {"entity": "publication", "iuid": "8c3b72858d46451ba01f4721713ac968", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c3b72858d46451ba01f4721713ac968.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c3b72858d46451ba01f4721713ac968"}}, "title": "European Hernia Society (EHS) guidance for the management of adult patients with a hernia during the COVID-19 pandemic.", "authors": [{"family": "Stabilini", "given": "C", "initials": "C"}, {"family": "East", "given": "B", "initials": "B"}, {"family": "Fortelny", "given": "R", "initials": "R"}, {"family": "Gillion", "given": "J-F", "initials": "J"}, {"family": "Lorenz", "given": "R", "initials": "R"}, {"family": "Montgomery", "given": "A", "initials": "A"}, {"family": "Morales-Conde", "given": "S", "initials": "S"}, {"family": "Muysoms", "given": "F", "initials": "F"}, {"family": "Pawlak", "given": "M", "initials": "M"}, {"family": "Reinpold", "given": "W", "initials": "W"}, {"family": "Simons", "given": "M", "initials": "M"}, {"family": "de Beaux", "given": "A C", "initials": "AC"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Hernia", "issn": "1248-9204", "issn-l": null, "volume": "24", "issue": "5", "pages": "977-983"}, "abstract": null, "doi": "10.1007/s10029-020-02212-8", "pmid": "32415652", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10029-020-02212-8"}, {"db": "pmc", "key": "PMC7227454"}], "notes": [], "created": "2020-12-10T08:53:10.937Z", "modified": "2020-12-11T14:19:18.837Z"}, {"entity": "publication", "iuid": "75c67caf246e413986c2d887261bb7d2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/75c67caf246e413986c2d887261bb7d2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/75c67caf246e413986c2d887261bb7d2"}}, "title": "Epidemic and pandemic viral infections: impact on tuberculosis and the lung: A consensus by the World Association for Infectious Diseases and Immunological Disorders (WAidid), Global Tuberculosis Network (GTN), and members of the European Society of Clinical Microbiology and Infectious Diseases Study Group for Mycobacterial Infections (ESGMYC).", "authors": [{"family": "Ong", "given": "Catherine Wei Min", "initials": "CWM"}, {"family": "Migliori", "given": "Giovanni Battista", "initials": "GB"}, {"family": "Raviglione", "given": "Mario", "initials": "M"}, {"family": "MacGregor-Skinner", "given": "Gavin", "initials": "G"}, {"family": "Sotgiu", "given": "Giovanni", "initials": "G"}, {"family": "Alffenaar", "given": "Jan-Willem", "initials": "JW"}, {"family": "Tiberi", "given": "Simon", "initials": "S"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Alonzi", "given": "Tonino", "initials": "T"}, {"family": "Archuleta", "given": "Sophia", "initials": "S"}, {"family": "Brusin", "given": "Sergio", "initials": "S"}, {"family": "Cambau", "given": "Emmanuelle", "initials": "E"}, {"family": "Capobianchi", "given": "Maria Rosaria", "initials": "MR"}, {"family": "Castilletti", "given": "Concetta", "initials": "C"}, {"family": "Centis", "given": "Rosella", "initials": "R"}, {"family": "Cirillo", "given": "Daniela M", "initials": "DM"}, {"family": "D'Ambrosio", "given": "Lia", "initials": "L"}, {"family": "Delogu", "given": "Giovanni", "initials": "G"}, {"family": "Esposito", "given": "Susanna M R", "initials": "SMR"}, {"family": "Figueroa", "given": "Jose", "initials": "J"}, {"family": "Friedland", "given": "Jon S", "initials": "JS"}, {"family": "Ho", "given": "Benjamin Choon Heng", "initials": "BCH"}, {"family": "Ippolito", "given": "Giuseppe", "initials": "G"}, {"family": "Jankovic", "given": "Mateja", "initials": "M"}, {"family": "Kim", "given": "Hannah Yejin", "initials": "HY"}, {"family": "Rosales Klintz", "given": "Senia", "initials": "S"}, {"family": "K\u00f6dm\u00f6n", "given": "Csaba", "initials": "C"}, {"family": "Lalle", "given": "Eleonora", "initials": "E"}, {"family": "Leo", "given": "Yee Sin", "initials": "YS"}, {"family": "Leung", "given": "Chi-Chiu", "initials": "CC"}, {"family": "M\u00e4rtson", "given": "Anne-Grete", "initials": "AG"}, {"family": "Melazzini", "given": "Mario Giovanni", "initials": "MG"}, {"family": "Najafi Fard", "given": "Saeid", "initials": "S"}, {"family": "Penttinen", "given": "Pasi", "initials": "P"}, {"family": "Petrone", "given": "Linda", "initials": "L"}, {"family": "Petruccioli", "given": "Elisa", "initials": "E"}, {"family": "Pontali", "given": "Emanuele", "initials": "E"}, {"family": "Saderi", "given": "Laura", "initials": "L"}, {"family": "Santin", "given": "Miguel", "initials": "M"}, {"family": "Spanevello", "given": "Antonio", "initials": "A"}, {"family": "van Crevel", "given": "Reinout", "initials": "R"}, {"family": "van der Werf", "given": "Marieke J", "initials": "MJ"}, {"family": "Visca", "given": "Dina", "initials": "D"}, {"family": "Viveiros", "given": "Miguel", "initials": "M"}, {"family": "Zellweger", "given": "Jean-Pierre", "initials": "JP"}, {"family": "Zumla", "given": "Alimuddin", "initials": "A"}, {"family": "Goletti", "given": "Delia", "initials": "D"}], "type": "consensus development conference", "published": "2020-10-00", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "volume": "56", "issue": "4", "issn-l": "0903-1936"}, "abstract": "Major epidemics, including some that qualify as pandemics, such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), HIV, influenza A (H1N1)pdm/09 and most recently COVID-19, affect the lung. Tuberculosis (TB) remains the top infectious disease killer, but apart from syndemic TB/HIV little is known regarding the interaction of viral epidemics and pandemics with TB. The aim of this consensus-based document is to describe the effects of viral infections resulting in epidemics and pandemics that affect the lung (MERS, SARS, HIV, influenza A (H1N1)pdm/09 and COVID-19) and their interactions with TB. A search of the scientific literature was performed. A writing committee of international experts including the European Centre for Disease Prevention and Control Public Health Emergency (ECDC PHE) team, the World Association for Infectious Diseases and Immunological Disorders (WAidid), the Global Tuberculosis Network (GTN), and members of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Mycobacterial Infections (ESGMYC) was established. Consensus was achieved after multiple rounds of revisions between the writing committee and a larger expert group. A Delphi process involving the core group of authors (excluding the ECDC PHE team) identified the areas requiring review/consensus, followed by a second round to refine the definitive consensus elements. The epidemiology and immunology of these viral infections and their interactions with TB are discussed with implications for diagnosis, treatment and prevention of airborne infections (infection control, viral containment and workplace safety). This consensus document represents a rapid and comprehensive summary on what is known on the topic.", "doi": "10.1183/13993003.01727-2020", "pmid": "32586885", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "13993003.01727-2020"}, {"db": "pmc", "key": "PMC7527651"}], "notes": [], "created": "2020-11-30T08:54:54.178Z", "modified": "2020-11-30T08:54:54.189Z"}, {"entity": "publication", "iuid": "3225f0c765e1457992c1dfecb0cc699e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3225f0c765e1457992c1dfecb0cc699e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3225f0c765e1457992c1dfecb0cc699e"}}, "title": "Effect of the COVID-19 pandemic response on intrapartum care, stillbirth, and neonatal mortality outcomes in Nepal: a prospective observational study.", "authors": [{"family": "Kc", "given": "Ashish", "initials": "A"}, {"family": "Gurung", "given": "Rejina", "initials": "R"}, {"family": "Kinney", "given": "Mary V", "initials": "MV"}, {"family": "Sunny", "given": "Avinash K", "initials": "AK"}, {"family": "Moinuddin", "given": "Md", "initials": "M"}, {"family": "Basnet", "given": "Omkar", "initials": "O"}, {"family": "Paudel", "given": "Prajwal", "initials": "P"}, {"family": "Bhattarai", "given": "Pratiksha", "initials": "P"}, {"family": "Subedi", "given": "Kalpana", "initials": "K"}, {"family": "Shrestha", "given": "Mahendra Prasad", "initials": "MP"}, {"family": "Lawn", "given": "Joy E", "initials": "JE"}, {"family": "M\u00e5lqvist", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Lancet Glob Health", "issn": "2214-109X", "issn-l": null, "volume": "8", "issue": "10", "pages": "e1273-e1281"}, "abstract": "The COVID-19 pandemic response is affecting maternal and neonatal health services all over the world. We aimed to assess the number of institutional births, their outcomes (institutional stillbirth and neonatal mortality rate), and quality of intrapartum care before and during the national COVID-19 lockdown in Nepal.\r\n\r\nIn this prospective observational study, we collected participant-level data for pregnant women enrolled in the SUSTAIN and REFINE studies between Jan 1 and May 30, 2020, from nine hospitals in Nepal. This period included 12\u00b75 weeks before the national lockdown and 9\u00b75 weeks during the lockdown. Women were eligible for inclusion if they had a gestational age of 22 weeks or more, a fetal heart sound at time of admission, and consented to inclusion. Women who had multiple births and their babies were excluded. We collected information on demographic and obstetric characteristics via extraction from case notes and health worker performance via direct observation by independent clinical researchers. We used regression analyses to assess changes in the number of institutional births, quality of care, and mortality before lockdown versus during lockdown.\r\n\r\nOf 22 907 eligible women, 21 763 women were enrolled and 20 354 gave birth, and health worker performance was recorded for 10 543 births. From the beginning to the end of the study period, the mean weekly number of births decreased from 1261\u00b71 births (SE 66\u00b71) before lockdown to 651\u00b74 births (49\u00b79) during lockdown-a reduction of 52\u00b74%. The institutional stillbirth rate increased from 14 per 1000 total births before lockdown to 21 per 1000 total births during lockdown (p=0\u00b70002), and institutional neonatal mortality increased from 13 per 1000 livebirths to 40 per 1000 livebirths (p=0\u00b70022). In terms of quality of care, intrapartum fetal heart rate monitoring decreased by 13\u00b74% (-15\u00b74 to -11\u00b73; p<0\u00b70001), and breastfeeding within 1 h of birth decreased by 3\u00b75% (-4\u00b76 to -2\u00b76; p=0\u00b70032). The immediate newborn care practice of placing the baby skin-to-skin with their mother increased by 13\u00b72% (12\u00b71 to 14\u00b75; p<0\u00b70001), and health workers' hand hygiene practices during childbirth increased by 12\u00b79% (11\u00b78 to 13\u00b79) during lockdown (p<0\u00b70001).\r\n\r\nInstitutional childbirth reduced by more than half during lockdown, with increases in institutional stillbirth rate and neonatal mortality, and decreases in quality of care. Some behaviours improved, notably hand hygiene and keeping the baby skin-to-skin with their mother. An urgent need exists to protect access to high quality intrapartum care and prevent excess deaths for the most vulnerable health system users during this pandemic period.\r\n\r\nGrand Challenges Canada.", "doi": "10.1016/S2214-109X(20)30345-4", "pmid": "32791117", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2214-109X(20)30345-4"}, {"db": "pmc", "key": "PMC7417164"}], "notes": [], "created": "2020-12-07T13:25:40.521Z", "modified": "2021-02-26T08:46:59.892Z"}, {"entity": "publication", "iuid": "8da6e2c62015459089ced85518bfb9cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8da6e2c62015459089ced85518bfb9cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8da6e2c62015459089ced85518bfb9cb"}}, "title": "Education for sustainable healthcare: Leadership to get from here to there.", "authors": [{"family": "McKimm", "given": "Judy", "initials": "J"}, {"family": "Redvers", "given": "Nicole", "initials": "N"}, {"family": "El Omrani", "given": "Omnia", "initials": "O"}, {"family": "Parkes", "given": "Margot W", "initials": "MW"}, {"family": "Elf", "given": "Marie", "initials": "M"}, {"family": "Woollard", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Med Teach", "issn": "1466-187X", "volume": "42", "issue": "10", "pages": "1123-1127", "issn-l": null}, "abstract": "The current global crises, including climate, COVID-19, and environmental change, requires global collective action at all scales. These broad socio-ecological challenges require the engagement of diverse perspectives and ways of knowing and the meaningful engagement of all generations and stages of personal and professional development. The combination of systems thinking, change management, quality improvement approaches and models, appreciative/strength-based approaches, narratives, storytelling and the strengths of Indigenous knowledges, offer synergies and potential that can set the stage for transformative, strengths-based education for sustainable healthcare (ESH). The need for strong leadership to enact a vision for ESH is outlined here with the intent to enable and nurture the conditions for change, ultimately improving health and well-being across generations.", "doi": "10.1080/0142159X.2020.1795104", "pmid": "32776858", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-07T13:32:42.469Z", "modified": "2020-12-07T13:32:42.488Z"}, {"entity": "publication", "iuid": "b15ba4b711654135a2ba50602ff79c98", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b15ba4b711654135a2ba50602ff79c98.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b15ba4b711654135a2ba50602ff79c98"}}, "title": "EXPOSED: An occupant exposure model for confined spaces to retrofit crowd models during a pandemic.", "authors": [{"family": "Ronchi", "given": "Enrico", "initials": "E"}, {"family": "Lovreglio", "given": "Ruggiero", "initials": "R"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Saf Sci", "issn": "0925-7535", "volume": "130", "issue": null, "pages": "104834", "issn-l": null}, "abstract": "Crowd models can be used for the simulation of people movement in the built environment. Crowd model outputs have been used for evaluating safety and comfort of pedestrians, inform crowd management and perform forensic investigations. Microscopic crowd models allow the representation of each person and the obtainment of information concerning their location over time and interactions with the physical space/other people. Pandemics such as COVID-19 have posed several questions on safe building usage, given the risk of disease transmission among building occupants. Here we show how crowd modelling can be used to assess occupant exposure in confined spaces. The policies adopted concerning building usage and social distancing during a pandemic can vary greatly, and they are mostly based on the macroscopic analysis of the spread of disease rather than a safety assessment performed at a building level. The proposed model allows the investigation of occupant exposure in buildings based on the analysis of microscopic people movement. Risk assessment is performed by retrofitting crowd models with a universal model for exposure assessment which can account for different types of disease transmissions. This work allows policy makers to perform informed decisions concerning building usage during a pandemic.", "doi": "10.1016/j.ssci.2020.104834", "pmid": "32834509", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0925-7535(20)30231-9"}, {"db": "pii", "key": "104834"}, {"db": "pmc", "key": "PMC7373681"}], "notes": [], "created": "2020-12-07T11:44:35.957Z", "modified": "2020-12-07T11:44:35.981Z"}, {"entity": "publication", "iuid": "171bcce7a979419cb54729a50448495c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/171bcce7a979419cb54729a50448495c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/171bcce7a979419cb54729a50448495c"}}, "title": "Dying From COVID-19: Loneliness, End-of-Life Discussions, and Support for Patients and Their Families in Nursing Homes and Hospitals. A National Register Study.", "authors": [{"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "Bergstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Martinsson", "given": "Lisa", "initials": "L"}, {"family": "Lundstr\u00f6m", "given": "Staffan", "initials": "S"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "J Pain Symptom Manage", "issn": "1873-6513", "issn-l": null, "volume": "60", "issue": "4", "pages": "e2-e13"}, "abstract": "Preparation for an impending death through end-of-life (EOL) discussions and human presence when a person is dying is important for both patients and families.\r\n\r\nThe aim was to study whether EOL discussions were offered and to what degree patients were alone at time of death when dying from coronavirus disease 2019 (COVID-19), comparing deaths in nursing homes and hospitals.\r\n\r\nThe national Swedish Register of Palliative Care was used. All expected deaths from COVID-19 in nursing homes and hospitals were compared with, and contrasted to, deaths in a reference population (deaths in 2019).\r\n\r\nA total of 1346 expected COVID-19 deaths in nursing homes (n = 908) and hospitals (n = 438) were analyzed. Those who died were of a more advanced age in nursing homes (mean 86.4 years) and of a lower age in hospitals (mean 80.7 years) (P < 0.0001). Fewer EOL discussions with patients were held compared with deaths in 2019 (74% vs. 79%, P < 0.001), and dying with someone present was much more uncommon (59% vs. 83%, P < 0.0001). In comparisons between nursing homes and hospital deaths, more patients dying in nursing homes were women (56% vs. 37%, P < 0.0001), and significantly fewer had a retained ability to express their will during the last week of life (54% vs. 89%, P < 0.0001). Relatives were present at time of death in only 13% and 24% of the cases in nursing homes and hospitals, respectively (P < 0.001). The corresponding figures for staff were 52% and 38% (P < 0.0001).\r\n\r\nDying from COVID-19 negatively affects the possibility of holding an EOL discussion and the chances of dying with someone present. This has considerable social and existential consequences for both patients and families.", "doi": "10.1016/j.jpainsymman.2020.07.020", "pmid": "32721500", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0885-3924(20)30630-8"}, {"db": "pmc", "key": "PMC7382350"}], "notes": [], "created": "2020-12-07T16:09:21.631Z", "modified": "2022-11-09T09:09:59.506Z"}, {"entity": "publication", "iuid": "abaafb213d3642919cb71f28b80149e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abaafb213d3642919cb71f28b80149e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abaafb213d3642919cb71f28b80149e7"}}, "title": "Dealing with uncertainty after transplantation in times of COVID-19.", "authors": [{"family": "Massey", "given": "Emma K", "initials": "EK"}, {"family": "Forsberg", "given": "Anna", "initials": "A"}], "type": "letter", "published": "2020-10-00", "journal": {"title": "Transpl Int", "issn": "1432-2277", "volume": "33", "issue": "10", "pages": "1337-1338", "issn-l": null}, "abstract": null, "doi": "10.1111/tri.13709", "pmid": "32725696", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-07T16:08:11.914Z", "modified": "2020-12-07T16:08:30.213Z"}, {"entity": "publication", "iuid": "5cfabeea139c408f8f4fab4b47469ca0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5cfabeea139c408f8f4fab4b47469ca0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5cfabeea139c408f8f4fab4b47469ca0"}}, "title": "Dataset of knowledge, attitude, practices and psychological implications of healthcare workers in Pakistan during COVID-19 pandemic.", "authors": [{"family": "Qasim", "given": "Muhammad", "initials": "M"}, {"family": "Awan", "given": "Usman Ayub", "initials": "UA"}, {"family": "Afzal", "given": "Muhammad Sohail", "initials": "MS"}, {"family": "Saqib", "given": "Muhammad Arif Nadeem", "initials": "MAN"}, {"family": "Siddiqui", "given": "Shajee", "initials": "S"}, {"family": "Ahmed", "given": "Haroon", "initials": "H"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Data Brief", "issn": "2352-3409", "issn-l": null, "volume": "32", "issue": null, "pages": "106234"}, "abstract": "The COVID-19 pandemic has created a global health emergency and has a huge impact on the health care workers, especially on their mental health. The dataset presented was an assessment of COVID-19 related knowledge, attitude, practices and its effects on the mental health of frontline healthcare workers in Pakistan. The data were collected using a snowball sampling technique. A questionnaire was developed assessing sociodemographic characteristics (6 items), knowledge (11 items), attitude (5 items), practices (6 items), information sources (1 item) and psychological implications (12 items) and distributed using online tools. The dataset includes 476 healthcare workers in Pakistan. The dataset will help to prevent and curb the spread of COVID-19 among health workers and contribute to policymakers. Furthermore, our dataset provides detailed insights into different risk factors of psychological problems, and it may be served as the reference for various in-depth surveys.", "doi": "10.1016/j.dib.2020.106234", "pmid": "32895632", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S2352-3409(20)31128-8"}, {"db": "pii", "key": "106234"}, {"db": "pmc", "key": "PMC7462453"}], "notes": [], "created": "2020-12-06T07:21:44.969Z", "modified": "2022-11-09T09:10:37.633Z"}, {"entity": "publication", "iuid": "4796c127b3264e32a6831ad545b0ff92", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4796c127b3264e32a6831ad545b0ff92.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4796c127b3264e32a6831ad545b0ff92"}}, "title": "Comprehensive investigation of an in-hospital transmission cluster of a symptomatic SARS-CoV-2-positive physician among patients and healthcare workers in Germany.", "authors": [{"family": "Wendt", "given": "Ralph", "initials": "R"}, {"family": "Nagel", "given": "Stephan", "initials": "S"}, {"family": "Nickel", "given": "Olaf", "initials": "O"}, {"family": "Wolf", "given": "Johannes", "initials": "J"}, {"family": "Kalbitz", "given": "Sven", "initials": "S"}, {"family": "Kaiser", "given": "Thorsten", "initials": "T"}, {"family": "Borte", "given": "Stephan", "initials": "S"}, {"family": "L\u00fcbbert", "given": "Christoph", "initials": "C"}], "type": "case reports", "published": "2020-10-00", "journal": {"title": "Infect Control Hosp Epidemiol", "issn": "1559-6834", "volume": "41", "issue": "10", "pages": "1209-1211", "issn-l": "0899-823X"}, "abstract": "We investigated potential transmissions of a symptomatic SARS-CoV-2-positive physician in a tertiary-care hospital who worked for 15 cumulative hours without wearing a face mask. No in-hospital transmissions occurred, despite 254 contacts among patients and healthcare workers. In conclusion, exposed hospital staff continued work, accompanied by close clinical and virologic monitoring.", "doi": "10.1017/ice.2020.268", "pmid": "32489162", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0899823X20002688"}, {"db": "pmc", "key": "PMC7298077"}], "notes": [], "created": "2020-11-25T09:41:22.284Z", "modified": "2021-02-26T08:45:48.105Z"}, {"entity": "publication", "iuid": "85157ee446f24772b44d5e9ac2539b9e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/85157ee446f24772b44d5e9ac2539b9e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/85157ee446f24772b44d5e9ac2539b9e"}}, "title": "Clarifications on Technologies to Optimize Care of Severe COVID-19 Patients.", "authors": [{"family": "Brull", "given": "Sorin J", "initials": "SJ"}, {"family": "Kopman", "given": "Aaron F", "initials": "AF"}], "type": "letter", "published": "2020-10-00", "journal": {"title": "Anesth Analg", "issn": "1526-7598", "volume": "131", "issue": "4", "pages": "e192-e193", "issn-l": null}, "abstract": null, "doi": "10.1213/ANE.0000000000005120", "pmid": "32665462", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7365583"}], "notes": [], "created": "2020-12-07T16:38:42.283Z", "modified": "2020-12-07T16:38:42.308Z"}, {"entity": "publication", "iuid": "0d54d30ef4aa4861a056b01048b810d1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d54d30ef4aa4861a056b01048b810d1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d54d30ef4aa4861a056b01048b810d1"}}, "title": "COVID-19, Mental Health, and Religious Coping Among American Orthodox Jews.", "authors": [{"family": "Pirutinsky", "given": "Steven", "initials": "S"}, {"family": "Cherniak", "given": "Aaron D", "initials": "AD"}, {"family": "Rosmarin", "given": "David H", "initials": "DH"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "J Relig Health", "issn": "1573-6571", "issn-l": null, "volume": "59", "issue": "5", "pages": "2288-2301"}, "abstract": "The COVID-19 pandemic presents potential mental health challenges, and the American Orthodox Jewish population has been particularly affected by the virus. The current study assessed the impact of the pandemic and explored the relationships between exposure, religiosity, and distress in a sample of n = 419 American Orthodox Jews. Results indicated high levels of exposure, concern, and compliance with medical guidelines; however stress was generally low and we found evidence for positive impact. Direct exposure correlated with higher religiosity. Positive religious coping, intrinsic religiosity and trust in God strongly correlated with less stress and more positive impact, while negative religious coping and mistrust in God correlated with the inverse. While the study is limited by its design, findings highlight that for some, faith may promote resilience especially during crisis.", "doi": "10.1007/s10943-020-01070-z", "pmid": "32705481", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10943-020-01070-z"}, {"db": "pmc", "key": "PMC7377309"}], "notes": [], "created": "2020-12-07T16:20:30.936Z", "modified": "2022-11-09T09:11:03.183Z"}, {"entity": "publication", "iuid": "5631ba3e9abe4a2c85c782382fa3aa01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5631ba3e9abe4a2c85c782382fa3aa01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5631ba3e9abe4a2c85c782382fa3aa01"}}, "title": "COVID-19 and the brain: impact on nuclear medicine in neurology.", "authors": [{"family": "Morbelli", "given": "Silvia", "initials": "S"}, {"family": "Ekmekcioglu", "given": "Ozgul", "initials": "O"}, {"family": "Barthel", "given": "Henryk", "initials": "H"}, {"family": "Albert", "given": "Nathalie L", "initials": "NL"}, {"family": "Boellaard", "given": "Ronald", "initials": "R"}, {"family": "Cecchin", "given": "Diego", "initials": "D"}, {"family": "Guedj", "given": "Eric", "initials": "E"}, {"family": "Lammertsma", "given": "Adriaan A", "initials": "AA"}, {"family": "Law", "given": "Ian", "initials": "I"}, {"family": "Penuelas", "given": "Ivan", "initials": "I"}, {"family": "Semah", "given": "Franck", "initials": "F"}, {"family": "Traub-Weidinger", "given": "Tatjana", "initials": "T"}, {"family": "van de Giessen", "given": "Elsmarieke", "initials": "E"}, {"family": "Varrone", "given": "Andrea", "initials": "A"}, {"family": "Garibotto", "given": "Valentina", "initials": "V"}, {"family": "EANM Neuroimaging Committee", "given": "", "initials": ""}], "type": "editorial", "published": "2020-10-00", "journal": {"title": "Eur J Nucl Med Mol Imaging", "issn": "1619-7089", "volume": "47", "issue": "11", "pages": "2487-2492", "issn-l": null}, "abstract": null, "doi": "10.1007/s00259-020-04965-x", "pmid": "32700058", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00259-020-04965-x"}, {"db": "pmc", "key": "PMC7375837"}], "notes": [], "created": "2020-12-07T16:22:42.972Z", "modified": "2020-12-07T16:22:42.994Z"}, {"entity": "publication", "iuid": "22760662d260465e845d059e37f99921", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/22760662d260465e845d059e37f99921.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/22760662d260465e845d059e37f99921"}}, "title": "COVID-19 and mental health among older people in Sweden.", "authors": [{"family": "Skoog", "given": "Ingmar", "initials": "I"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Int Psychogeriatr", "issn": "1741-203X", "volume": "32", "issue": "10", "pages": "1173-1175", "issn-l": null}, "abstract": null, "doi": "10.1017/S104161022000143X", "pmid": "32635950", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S104161022000143X"}, {"db": "pmc", "key": "PMC7403743"}], "notes": [], "created": "2020-12-08T14:34:03.903Z", "modified": "2020-12-08T14:34:03.926Z"}, {"entity": "publication", "iuid": "6bb2344e298d441e9b2aa29db8f34878", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6bb2344e298d441e9b2aa29db8f34878.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6bb2344e298d441e9b2aa29db8f34878"}}, "title": "Build back stronger universal health coverage systems after the COVID-19 pandemic: the need for better governance and linkage with universal social protection.", "authors": [{"family": "Tediosi", "given": "Fabrizio", "initials": "F"}, {"family": "L\u00f6nnroth", "given": "Knut", "initials": "K"}, {"family": "Pablos-M\u00e9ndez", "given": "Ariel", "initials": "A"}, {"family": "Raviglione", "given": "Mario", "initials": "M"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "issn-l": "2059-7908", "volume": "5", "issue": "10", "pages": null}, "abstract": "Commentary", "doi": "10.1136/bmjgh-2020-004020", "pmid": "33122298", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-004020"}, {"db": "pmc", "key": "PMC7597511"}], "notes": [], "created": "2020-11-27T10:19:52.601Z", "modified": "2022-11-09T09:12:02.304Z"}, {"entity": "publication", "iuid": "be2ebedd6233495a88eb38cb95b66764", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be2ebedd6233495a88eb38cb95b66764.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be2ebedd6233495a88eb38cb95b66764"}}, "title": "Assessing the fear of COVID-19 among different populations: A response to Ransing et al. (2020).", "authors": [{"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Chang", "given": "Kun-Chia", "initials": "KC"}, {"family": "Chen", "given": "Yu-Pin", "initials": "YP"}, {"family": "Kuo", "given": "Yi-Jie", "initials": "YJ"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}], "type": "letter", "published": "2020-10-00", "journal": {"title": "Brain Behav Immun", "issn": "1090-2139", "volume": "89", "issue": null, "pages": "524-525", "issn-l": null}, "abstract": null, "doi": "10.1016/j.bbi.2020.06.006", "pmid": "32512132", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0889-1591(20)31198-3"}, {"db": "pmc", "key": "PMC7274088"}], "notes": [], "created": "2020-12-09T10:33:23.328Z", "modified": "2020-12-09T10:33:23.350Z"}, {"entity": "publication", "iuid": "d1bb3e2646f840f3bacba6c587c03e3a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1bb3e2646f840f3bacba6c587c03e3a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1bb3e2646f840f3bacba6c587c03e3a"}}, "title": "Advocacy for the human rights of older people in the COVID pandemic and beyond: a call to mental health professionals.", "authors": [{"family": "Peisah", "given": "Carmelle", "initials": "C"}, {"family": "Byrnes", "given": "Andrew", "initials": "A"}, {"family": "Doron", "given": "Israel Issi", "initials": "II"}, {"family": "Dark", "given": "Michael", "initials": "M"}, {"family": "Quinn", "given": "Gerard", "initials": "G"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Int Psychogeriatr", "issn": "1741-203X", "issn-l": null, "volume": "32", "issue": "10", "pages": "1199-1204"}, "abstract": null, "doi": "10.1017/S1041610220001076", "pmid": "32487280", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1041610220001076"}, {"db": "pmc", "key": "PMC7302948"}], "notes": [], "created": "2020-12-09T10:53:49.868Z", "modified": "2020-12-11T12:49:56.181Z"}, {"entity": "publication", "iuid": "3ae6115f8aed497694523e954dd74313", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ae6115f8aed497694523e954dd74313.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ae6115f8aed497694523e954dd74313"}}, "title": "Adaptation of evidence-based suicide prevention strategies during and after the COVID-19 pandemic.", "authors": [{"family": "Wasserman", "given": "Danuta", "initials": "D"}, {"family": "Iosue", "given": "Miriam", "initials": "M"}, {"family": "Wuestefeld", "given": "Anika", "initials": "A"}, {"family": "Carli", "given": "Vladimir", "initials": "V"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "World Psychiatry", "issn": "1723-8617", "volume": "19", "issue": "3", "pages": "294-306", "issn-l": null}, "abstract": "Suicide is preventable. Nevertheless, each year 800,000 people die of suicide in the world. While there is evidence indicating that suicide rates de-crease during times of crises, they are expected to increase once the immediate crisis has passed. The COVID-19 pandemic affects risk and pro-tective factors for suicide at each level of the socio-ecological model. Economic downturn, augmented barriers to accessing health care, increased access to suicidal means, inappropriate media reporting at the societal level; deprioritization of mental health and preventive activities at the community level; interpersonal conflicts, neglect and violence at the relationship level; unemployment, poverty, loneliness and hopelessness at the individual level: all these variables contribute to an increase of depression, anxiety, post-traumatic stress disorder, harmful use of alcohol, substance abuse, and ultimately suicide risk. Suicide should be prevented by strengthening universal strategies directed to the entire population, including mitigation of unemployment, poverty and inequalities; prioritization of access to mental health care; responsible media reporting, with information about available support; prevention of increased alcohol intake; and restriction of access to lethal means of suicide. Selective interventions should continue to target known vulnerable groups who are socio-economically disadvantaged, but also new ones such as first responders and health care staff, and the bereaved by COVID-19 who have been deprived of the final contact with loved ones and funerals. Indicated preventive strategies targeting individuals who display suicidal behaviour should focus on available pharmacological and psychological treatments of mental disorders, ensuring proper follow-up and chain of care by increased use of telemedicine and other digital means. The scientific community, health care professionals, politicians and decision-makers will find in this paper a systematic description of the effects of the pandemic on suicide risk at the society, community, family and individual levels, and an overview of how evidence-based suicide preventive interventions should be adapted. Research is needed to investigate which adaptations are effective and in which con-texts.", "doi": "10.1002/wps.20801", "pmid": "32931107", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7491639"}], "notes": [], "created": "2020-12-03T15:34:27.996Z", "modified": "2020-12-03T15:34:28.019Z"}, {"entity": "publication", "iuid": "c6465dd934734f92a6dcc63a323d6953", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c6465dd934734f92a6dcc63a323d6953.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c6465dd934734f92a6dcc63a323d6953"}}, "title": "ATMO-vent: An adapted breathing atmosphere for COVID-19 patients.", "authors": [{"family": "Mathanlal", "given": "Thasshwin", "initials": "T"}, {"family": "Israel Nazarious", "given": "Miracle", "initials": "M"}, {"family": "Mantas-Nakhai", "given": "Roberto", "initials": "R"}, {"family": "Zorzano", "given": "Maria-Paz", "initials": "MP"}, {"family": "Martin-Torres", "given": "Javier", "initials": "J"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "HardwareX", "issn": "2468-0672", "volume": "8", "issue": null, "pages": "e00145", "issn-l": null}, "abstract": "The ongoing worldwide pandemic of coronavirus disease 2019 (COVID-19), has been one of the most significant challenges to humankind in centuries. The extremely contagious nature of the SARS-CoV-2 virus has put forth an immense pressure on the health sector. In order to mitigate the stress on the healthcare systems especially to battle the crisis of mechanical ventilators, we have designed a modular, and robust DIY ventilator, ATMO-Vent (Atmospheric Mixture Optimization Ventilator) which can be fully mounted within two days by two operators. The ATMO-Vent has been designed using low-cost, robust, Commercial Off The Shelf (COTS) components, with many features comparable to a full-fledged ventilator. ATMO-Vent has been designed based on the United Kingdom Medicines & Healthcare products Regulatory Agency (UK-MHRA) guidelines for Rapidly Manufactured Ventilator System (RMVS), yet is scalable to the specific requirements of different countries. ATMO-Vent is capable of adjusting the Fraction of Inspiratory Oxygen (FiO 2) levels, Tidal Volume (TV), frequency of breaths, Inspiratory/Expiratory ratio (I/E), Peak Inspiratory Pressure (PIP) and Positive End-Expiratory Pressure (PEEP). ATMO-Vent can operate in two modes - Continuous Mandatory Ventilation (CMV) using Volume-Controlled Ventilation (VCV) and in Assisted Control (AC) mode with pressure triggered by the patient. ATMO-Vent has undergone rigorous testing and qualifies under Class B Electric and Magnetic Compatibility (EMC) requirements of EN 55,011 CISPR 11 standards.", "doi": "10.1016/j.ohx.2020.e00145", "pmid": "33015423", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2468-0672(20)30054-7"}, {"db": "pmc", "key": "PMC7518965"}], "notes": [], "created": "2020-12-03T08:52:38.086Z", "modified": "2020-12-03T08:52:38.097Z"}, {"entity": "publication", "iuid": "96f7ca266c114d4094a654bf661590b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/96f7ca266c114d4094a654bf661590b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/96f7ca266c114d4094a654bf661590b2"}}, "title": "A compendium answering 150 questions on COVID-19 and SARS-CoV-2.", "authors": [{"family": "Riggioni", "given": "Carmen", "initials": "C"}, {"family": "Comberiati", "given": "Pasquale", "initials": "P"}, {"family": "Giovannini", "given": "Mattia", "initials": "M"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Akdis", "given": "M\u00fcbeccel", "initials": "M"}, {"family": "Alves-Correia", "given": "Magna", "initials": "M"}, {"family": "Ant\u00f3", "given": "Josep M", "initials": "JM"}, {"family": "Arcolaci", "given": "Alessandra", "initials": "A"}, {"family": "Azkur", "given": "Ahmet Kursat", "initials": "AK"}, {"family": "Azkur", "given": "Dilek", "initials": "D"}, {"family": "Beken", "given": "Burcin", "initials": "B"}, {"family": "Boccabella", "given": "Cristina", "initials": "C"}, {"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Breiteneder", "given": "Heimo", "initials": "H"}, {"family": "Carvalho", "given": "Daniela", "initials": "D"}, {"family": "De Las Vecillas", "given": "Leticia", "initials": "L"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}, {"family": "Eguiluz-Gracia", "given": "Ibon", "initials": "I"}, {"family": "Eiwegger", "given": "Thomas", "initials": "T"}, {"family": "Eyerich", "given": "Stefanie", "initials": "S"}, {"family": "Fokkens", "given": "Wytske", "initials": "W"}, {"family": "Gao", "given": "Ya-Dong", "initials": "YD"}, {"family": "Hannachi", "given": "Farah", "initials": "F"}, {"family": "Johnston", "given": "Sebastian L", "initials": "SL"}, {"family": "Jutel", "given": "Marek", "initials": "M"}, {"family": "Karavelia", "given": "Aspasia", "initials": "A"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Moya", "given": "Beatriz", "initials": "B"}, {"family": "Nadeau", "given": "Kari C", "initials": "KC"}, {"family": "O'Hehir", "given": "Robyn", "initials": "R"}, {"family": "O'Mahony", "given": "Liam", "initials": "L"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Sanak", "given": "Marek", "initials": "M"}, {"family": "Schwarze", "given": "J\u00fcrgen", "initials": "J"}, {"family": "Sokolowska", "given": "Milena", "initials": "M"}, {"family": "Torres", "given": "Mar\u00eda J", "initials": "MJ"}, {"family": "van de Veen", "given": "Willem", "initials": "W"}, {"family": "van Zelm", "given": "Menno C", "initials": "MC"}, {"family": "Wang", "given": "De Yun", "initials": "Y"}, {"family": "Zhang", "given": "Luo", "initials": "L"}, {"family": "Jim\u00e9nez-Saiz", "given": "Rodrigo", "initials": "R"}, {"family": "Akdis", "given": "Cezmi A", "initials": "CA"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": "75", "issue": "10", "pages": "2503-2541", "issn-l": "0105-4538"}, "abstract": "In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date, it has resulted in ~9 million confirmed cases and caused almost 500 000 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socioeconomic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19. Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a \"cytokine storm\" leading to acute respiratory distress syndrome, endothelitis, thromboembolic complications, and multiorgan failure. The epidemiologic features of COVID-19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID-19-related topics should be based on more coordinated high-quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19, and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development, and epidemiology. A total of 150 questions were answered by experts in the field providing a comprehensive and practical overview of COVID-19 and allergic disease.", "doi": "10.1111/all.14449", "pmid": "32535955", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7323196"}], "notes": [], "created": "2020-11-30T09:00:22.912Z", "modified": "2020-11-30T09:00:22.921Z"}, {"entity": "publication", "iuid": "ef2d70107eb54e599739267f1d63e241", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef2d70107eb54e599739267f1d63e241.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef2d70107eb54e599739267f1d63e241"}}, "title": "A commentary on \"The trouble with trust: Time-series analysis of social capital, income inequality, and COVID-19 deaths in 84 countries\".", "authors": [{"family": "Lindstr\u00f6m", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Soc Sci Med", "issn": "1873-5347", "issn-l": null, "volume": "263", "issue": null, "pages": "113386"}, "abstract": "Comment\r\nThis study investigates associations between central aspects of social capital (social trust, group affiliations, civic engagement, confidence in state institutions), income inequality (Gini index for income), and COVID-19 mortality in 84 countries included in different time waves of the World Values Survey (WVS) (Elgar et al., 2020). Comments: First, infectious diseases are either patterned according to socioeconomic status (SES), determined by e.g. habitus, nutrition and crowded housing or clustering, or not according to SES. Second, the focus on economic inequality measured as income inequality (Gini index) should be complemented with measures of wealth inequality (Gini index for wealth), following the globalization process with tax exempted multinational companies. Third, the aspects of social capital were measured in different time waves of the World Values Survey (WVS) for different countries, which is a weakness because trust and other aspects of social capital vary over time and depend on specific events and social and economic trends.", "doi": "10.1016/j.socscimed.2020.113386", "pmid": "33036797", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0277-9536(20)30605-5"}, {"db": "pmc", "key": "PMC7532747"}], "notes": [], "created": "2020-12-01T17:26:58.810Z", "modified": "2020-12-01T17:27:46.293Z"}, {"entity": "publication", "iuid": "37842769c6394a15b1f9ad6e57ec202a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/37842769c6394a15b1f9ad6e57ec202a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/37842769c6394a15b1f9ad6e57ec202a"}}, "title": "Updated guidance on the management of COVID-19: from an American Thoracic Society/European Respiratory Society coordinated International Task Force (29 July 2020).", "authors": [{"family": "Bai", "given": "Chunxue", "initials": "C"}, {"family": "Chotirmall", "given": "Sanjay H", "initials": "SH"}, {"family": "Rello", "given": "Jordi", "initials": "J"}, {"family": "Alba", "given": "George A", "initials": "GA"}, {"family": "Ginns", "given": "Leo C", "initials": "LC"}, {"family": "Krishnan", "given": "Jerry A", "initials": "JA"}, {"family": "Rogers", "given": "Robert", "initials": "R"}, {"family": "Bendstrup", "given": "Elisabeth", "initials": "E"}, {"family": "Burgel", "given": "Pierre-Regis", "initials": "PR"}, {"family": "Chalmers", "given": "James D", "initials": "JD"}, {"family": "Chua", "given": "Abigail", "initials": "A"}, {"family": "Crothers", "given": "Kristina A", "initials": "KA"}, {"family": "Duggal", "given": "Abhijit", "initials": "A"}, {"family": "Kim", "given": "Yeon Wook", "initials": "YW"}, {"family": "Laffey", "given": "John G", "initials": "JG"}, {"family": "Luna", "given": "Carlos M", "initials": "CM"}, {"family": "Niederman", "given": "Michael S", "initials": "MS"}, {"family": "Raghu", "given": "Ganesh", "initials": "G"}, {"family": "Ramirez", "given": "Julio A", "initials": "JA"}, {"family": "Riera", "given": "Jordi", "initials": "J"}, {"family": "Roca", "given": "Oriol", "initials": "O"}, {"family": "Tamae-Kakazu", "given": "Maximiliano", "initials": "M"}, {"family": "Torres", "given": "Antoni", "initials": "A"}, {"family": "Watkins", "given": "Richard R", "initials": "RR"}, {"family": "Barrecheguren", "given": "Miriam", "initials": "M"}, {"family": "Belliato", "given": "Mirko", "initials": "M"}, {"family": "Chami", "given": "Hassan A", "initials": "HA"}, {"family": "Chen", "given": "Rongchang", "initials": "R"}, {"family": "Cortes-Puentes", "given": "Gustavo A", "initials": "GA"}, {"family": "Delacruz", "given": "Charles", "initials": "C"}, {"family": "Hayes", "given": "Margaret M", "initials": "MM"}, {"family": "Heunks", "given": "Leo M A", "initials": "LMA"}, {"family": "Holets", "given": "Steven R", "initials": "SR"}, {"family": "Hough", "given": "Catherine L", "initials": "CL"}, {"family": "Jagpal", "given": "Sugeet", "initials": "S"}, {"family": "Jeon", "given": "Kyeongman", "initials": "K"}, {"family": "Johkoh", "given": "Takeshi", "initials": "T"}, {"family": "Lee", "given": "May M", "initials": "MM"}, {"family": "Liebler", "given": "Janice", "initials": "J"}, {"family": "McElvaney", "given": "Gerry N", "initials": "GN"}, {"family": "Moskowitz", "given": "Ari", "initials": "A"}, {"family": "Oeckler", "given": "Richard A", "initials": "RA"}, {"family": "Ojanguren", "given": "I\u00f1igo", "initials": "I"}, {"family": "O'Regan", "given": "Anthony", "initials": "A"}, {"family": "Pletz", "given": "Mathias W", "initials": "MW"}, {"family": "Rhee", "given": "Chin Kook", "initials": "CK"}, {"family": "Schultz", "given": "Marcus J", "initials": "MJ"}, {"family": "Storti", "given": "Enrico", "initials": "E"}, {"family": "Strange", "given": "Charlie", "initials": "C"}, {"family": "Thomson", "given": "Carey C", "initials": "CC"}, {"family": "Torriani", "given": "Francesca J", "initials": "FJ"}, {"family": "Wang", "given": "Xun", "initials": "X"}, {"family": "Wuyts", "given": "Wim", "initials": "W"}, {"family": "Xu", "given": "Tao", "initials": "T"}, {"family": "Yang", "given": "Dawei", "initials": "D"}, {"family": "Zhang", "given": "Ziqiang", "initials": "Z"}, {"family": "Wilson", "given": "Kevin C", "initials": "KC"}], "type": "journal article", "published": "2020-09-30", "journal": {"title": "Eur Respir Rev", "issn": "1600-0617", "volume": "29", "issue": "157", "issn-l": "0905-9180"}, "abstract": "Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome-coronavirus-2. Consensus suggestions can standardise care, thereby improving outcomes and facilitating future research.\n\nAn International Task Force was composed and agreement regarding courses of action was measured using the Convergence of Opinion on Recommendations and Evidence (CORE) process. 70% agreement was necessary to make a consensus suggestion.\n\nThe Task Force made consensus suggestions to treat patients with acute COVID-19 pneumonia with remdesivir and dexamethasone but suggested against hydroxychloroquine except in the context of a clinical trial; these are revisions of prior suggestions resulting from the interim publication of several randomised trials. It also suggested that COVID-19 patients with a venous thromboembolic event be treated with therapeutic anticoagulant therapy for 3 months. The Task Force was unable to reach sufficient agreement to yield consensus suggestions for the post-hospital care of COVID-19 survivors. The Task Force fell one vote shy of suggesting routine screening for depression, anxiety and post-traumatic stress disorder.\n\nThe Task Force addressed questions related to pharmacotherapy in patients with COVID-19 and the post-hospital care of survivors, yielding several consensus suggestions. Management options for which there is insufficient agreement to formulate a suggestion represent research priorities.", "doi": "10.1183/16000617.0287-2020", "pmid": "33020069", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "29/157/200287"}, {"db": "pmc", "key": "PMC7537943"}], "notes": [], "created": "2020-11-27T12:39:01.420Z", "modified": "2020-11-27T12:39:01.445Z"}, {"entity": "publication", "iuid": "2e68cc9fd8374ee184f801694fbe140c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e68cc9fd8374ee184f801694fbe140c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e68cc9fd8374ee184f801694fbe140c"}}, "title": "The major genetic risk factor for severe COVID-19 is inherited from Neanderthals.", "authors": [{"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "P\u00e4\u00e4bo", "given": "Svante", "initials": "S"}], "type": "journal article", "published": "2020-09-30", "journal": {"title": "Nature", "issn": "1476-4687", "issn-l": "0028-0836", "volume": "587", "issue": "7835", "pages": "610-612"}, "abstract": "A recent genetic association study 1 identified a gene cluster on chromosome 3 as a risk locus for respiratory failure after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A separate study (COVID-19 Host Genetics Initiative)2 comprising 3,199 hospitalized patients with coronavirus disease 2019 (COVID-19) and control individuals showed that this cluster is the major genetic risk factor for severe symptoms after SARS-CoV-2 infection and hospitalization. Here we show that the risk is conferred by a genomic segment of around 50 kilobases in size that is inherited from Neanderthals and is carried by around 50% of people in south Asia and around 16% of people in Europe.", "doi": "10.1038/s41586-020-2818-3", "pmid": "32998156", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41586-020-2818-3"}, {"db": "URL", "key": "http://genome.ucsc.edu/cgi-bin/hgTrackUi?db=hg38&g=covidHgiGwas", "description": "COVID-19 Host Genetics Initiative (round 3, ANA_B2_V2):  summary statistics of the genome-wide association study"}, {"db": "NA", "key": "Genetic information used in the study are available in public repositories (e.g. http://cdna.eva.mpg.de/neandertal/)", "description": null}], "notes": [], "created": "2020-11-18T17:00:53.715Z", "modified": "2021-11-18T09:10:47.724Z"}, {"entity": "publication", "iuid": "450e8ebbae3a45899766c71e26df149c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/450e8ebbae3a45899766c71e26df149c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/450e8ebbae3a45899766c71e26df149c"}}, "title": "Innate Immune Responses to Acute Viral Infection During Pregnancy.", "authors": [{"family": "Cornish", "given": "Emily F", "initials": "EF"}, {"family": "Filipovic", "given": "Iva", "initials": "I"}, {"family": "\u00c5senius", "given": "Fredrika", "initials": "F"}, {"family": "Williams", "given": "David J", "initials": "DJ"}, {"family": "McDonnell", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2020-09-30", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "11", "issue": null, "pages": "572567", "issn-l": "1664-3224"}, "abstract": "Immunological adaptations in pregnancy allow maternal tolerance of the semi-allogeneic fetus but also increase maternal susceptibility to infection. At implantation, the endometrial stroma, glands, arteries and immune cells undergo anatomical and functional transformation to create the decidua, the specialized secretory endometrium of pregnancy. The maternal decidua and the invading fetal trophoblast constitute a dynamic junction that facilitates a complex immunological dialogue between the two. The decidual and peripheral immune systems together assume a pivotal role in regulating the critical balance between tolerance and defense against infection. Throughout pregnancy, this equilibrium is repeatedly subjected to microbial challenge. Acute viral infection in pregnancy is associated with a wide spectrum of adverse consequences for both mother and fetus. Vertical transmission from mother to fetus can cause developmental anomalies, growth restriction, preterm birth and stillbirth, while the mother is predisposed to heightened morbidity and maternal death. A rapid, effective response to invasive pathogens is therefore essential in order to avoid overwhelming maternal infection and consequent fetal compromise. This sentinel response is mediated by the innate immune system: a heritable, highly evolutionarily conserved system comprising physical barriers, antimicrobial peptides (AMP) and a variety of immune cells-principally neutrophils, macrophages, dendritic cells, and natural killer cells-which express pattern-receptors that detect invariant molecular signatures unique to pathogenic micro-organisms. Recognition of these signatures during acute infection triggers signaling cascades that enhance antimicrobial properties such as phagocytosis, secretion of pro-inflammatory cytokines and activation of the complement system. As well as coordinating the initial immune response, macrophages and dendritic cells present microbial antigens to lymphocytes, initiating and influencing the development of specific, long-lasting adaptive immunity. Despite extensive progress in unraveling the immunological adaptations of pregnancy, pregnant women remain particularly susceptible to certain acute viral infections and continue to experience mortality rates equivalent to those observed in pandemics several decades ago. Here, we focus specifically on the pregnancy-induced vulnerabilities in innate immunity that contribute to the disproportionately high maternal mortality observed in the following acute viral infections: Lassa fever, Ebola virus disease (EVD), dengue fever, hepatitis E, influenza, and novel coronavirus infections.", "doi": "10.3389/fimmu.2020.572567", "pmid": "33101294", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7556209"}], "notes": [], "created": "2020-11-26T12:26:42.810Z", "modified": "2020-11-27T11:47:54.134Z"}, {"entity": "publication", "iuid": "7349e144370e444abab068898e378e7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7349e144370e444abab068898e378e7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7349e144370e444abab068898e378e7e"}}, "title": "Impact of Coronavirus Disease 2019 (COVID-19) Outbreak on Acute Admissions at the Emergency and Cardiology Departments Across Europe.", "authors": [{"family": "Sokolski", "given": "Mateusz", "initials": "M"}, {"family": "Gajewski", "given": "Piotr", "initials": "P"}, {"family": "Zymli\u0144ski", "given": "Robert", "initials": "R"}, {"family": "Biegus", "given": "Jan", "initials": "J"}, {"family": "Berg", "given": "Jurrien M Ten", "initials": "JMT"}, {"family": "Bor", "given": "Wilbert", "initials": "W"}, {"family": "Braunschweig", "given": "Frieder", "initials": "F"}, {"family": "Caldeira", "given": "Daniel", "initials": "D"}, {"family": "Cuculi", "given": "Florim", "initials": "F"}, {"family": "D'Elia", "given": "Emilia", "initials": "E"}, {"family": "Edes", "given": "Istvan Ferenc", "initials": "IF"}, {"family": "Garus", "given": "Mateusz", "initials": "M"}, {"family": "Greenwood", "given": "John P", "initials": "JP"}, {"family": "Halfwerk", "given": "Frank R", "initials": "FR"}, {"family": "Hindricks", "given": "Gerhard", "initials": "G"}, {"family": "Knuuti", "given": "Juhani", "initials": "J"}, {"family": "Kristensen", "given": "Steen Dalby", "initials": "SD"}, {"family": "Landmesser", "given": "Ulf", "initials": "U"}, {"family": "Lund", "given": "Lars H", "initials": "LH"}, {"family": "Lyon", "given": "Alexander", "initials": "A"}, {"family": "Mebazaa", "given": "Alexandre", "initials": "A"}, {"family": "Merkely", "given": "B\u00e9la", "initials": "B"}, {"family": "Nawrocka-Millward", "given": "Sylwia", "initials": "S"}, {"family": "Pinto", "given": "Fausto J", "initials": "FJ"}, {"family": "Ruschitzka", "given": "Frank", "initials": "F"}, {"family": "Semedo", "given": "Edimir", "initials": "E"}, {"family": "Senni", "given": "Michele", "initials": "M"}, {"family": "Sepehri Shamloo", "given": "Alireza", "initials": "A"}, {"family": "Sorensen", "given": "Jacob", "initials": "J"}, {"family": "Stengaard", "given": "Carsten", "initials": "C"}, {"family": "Thiele", "given": "Holger", "initials": "H"}, {"family": "Toggweiler", "given": "Stefan", "initials": "S"}, {"family": "Tukiendorf", "given": "Andrzej", "initials": "A"}, {"family": "Verhorst", "given": "Patrick M", "initials": "PM"}, {"family": "Wright", "given": "David Jay", "initials": "DJ"}, {"family": "Zamorano", "given": "Pepe", "initials": "P"}, {"family": "Zuber", "given": "Michel", "initials": "M"}, {"family": "Narula", "given": "Jagat", "initials": "J"}, {"family": "Bax", "given": "Jeroen J", "initials": "JJ"}, {"family": "Ponikowski", "given": "Piotr", "initials": "P"}], "type": "journal article", "published": "2020-09-30", "journal": {"title": "Am J Med", "issn": "1555-7162", "volume": null, "issue": null, "issn-l": null}, "abstract": "We evaluated whether the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) pandemic was associated with changes in the pattern of acute cardiovascular admissions across European centers.\n\nWe set-up a multicenter, multinational, pan-European observational registry in 15 centers from 12 countries. All consecutive acute admissions to emergency departments and cardiology departments throughout a 1-month period during the COVID-19 outbreak were compared with an equivalent 1-month period in 2019. The acute admissions to cardiology departments were classified into 5 major categories: acute coronary syndrome, acute heart failure, arrhythmia, pulmonary embolism, and other.\n\nData from 54,331 patients were collected and analyzed. Nine centers provided data on acute admissions to emergency departments comprising 50,384 patients: 20,226 in 2020 compared with 30,158 in 2019 (incidence rate ratio [IRR] with 95% confidence interval [95%CI]: 0.66 [0.58-0.76]). The risk of death at the emergency departments was higher in 2020 compared to 2019 (odds ratio [OR] with 95% CI: 4.1 [3.0-5.8], P < 0.0001). All 15 centers provided data on acute cardiology departments admissions: 3007 patients in 2020 and 4452 in 2019; IRR (95% CI): 0.68 (0.64-0.71). In 2020, there were fewer admissions with IRR (95% CI): acute coronary syndrome: 0.68 (0.63-0.73); acute heart failure: 0.65 (0.58-0.74); arrhythmia: 0.66 (0.60-0.72); and other: 0.68(0.62-0.76). We found a relatively higher percentage of pulmonary embolism admissions in 2020: odds ratio (95% CI): 1.5 (1.1-2.1), P = 0.02. Among patients with acute coronary syndrome, there were fewer admissions with unstable angina: 0.79 (0.66-0.94); non-ST segment elevation myocardial infarction: 0.56 (0.50-0.64); and ST-segment elevation myocardial infarction: 0.78 (0.68-0.89).\n\nIn the European centers during the COVID-19 outbreak, there were fewer acute cardiovascular admissions. Also, fewer patients were admitted to the emergency departments with 4 times higher death risk at the emergency departments.", "doi": "10.1016/j.amjmed.2020.08.043", "pmid": "33010226", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0002-9343(20)30825-1"}, {"db": "pmc", "key": "PMC7526639"}], "notes": [], "created": "2020-12-03T08:54:27.721Z", "modified": "2021-02-26T08:46:13.256Z"}, {"entity": "publication", "iuid": "55408eb290b74ff58a7e7ce77a376726", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/55408eb290b74ff58a7e7ce77a376726.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/55408eb290b74ff58a7e7ce77a376726"}}, "title": "Transitioning Between Online Gambling Modalities and Decrease in Total Gambling Activity, but No Indication of Increase in Problematic Online Gambling Intensity During the First Phase of the COVID-19 Outbreak in Sweden: A Time Series Forecast Study.", "authors": [{"family": "Lindner", "given": "Philip", "initials": "P"}, {"family": "Forsstr\u00f6m", "given": "David", "initials": "D"}, {"family": "Jonsson", "given": "Jakob", "initials": "J"}, {"family": "Berman", "given": "Anne H", "initials": "AH"}, {"family": "Carlbring", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2020-09-29", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "8", "issue": null, "pages": "554542"}, "abstract": "Introduction: The COVID-19 outbreak will likely have a public health impact beyond immediate disease transmission. Little is known about whether social distancing and other societal changes has provoked an increase in gambling, whether decreased betting opportunities due to paused sports events spurred gamblers to transition to online casino gambling, or whether any of these factors have had an impact on problem gambling. Methods: Data on lookup queries against the Swedish Gambling Paus registry, logging all initiated gambling sessions by all licensed gambling providers, from 2019-01-01 (start of registry) to 2020-04-08 (well into the first phase of the outbreak) were analyzed using TBATS time series forecasting to estimate trends after the first domestic COVID-19 death. Obfuscated data on daily total wagered and deposited amounts, split by modality (casino or betting, and low and high intensity, respectively) for the equivalent period were supplied by a licensed online gambling provider. Results: Total gambling activity decreased by 13.29% during the first phase of the outbreak compared to forecast. Analyses of online gambling data revealed that although betting decreased substantially in synchrony with a slight increase in online casino gambling, there was no increase in likely problematic, high-intensity gambling and neither did total online gambling increase. Conclusions: This first, preliminary study revealed no increase in Swedish gambling activity, total or specifically online, in the first phase of the COVID-19 outbreak. Future research should examine whether pandemic-induced transitioning between gambling modalities and/or increased participation in gambling, leads to long-term effects on prevalence of problem gambling.", "doi": "10.3389/fpubh.2020.554542", "pmid": "33117770", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7550730"}], "notes": [], "created": "2020-12-01T15:10:25.688Z", "modified": "2023-06-19T14:25:31.050Z"}, {"entity": "publication", "iuid": "252e6e3b499a4f00b054837e86a9f448", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/252e6e3b499a4f00b054837e86a9f448.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/252e6e3b499a4f00b054837e86a9f448"}}, "title": "Presence of SARS-CoV-2 in urine is rare and not associated with acute kidney injury in critically ill COVID-19 patients.", "authors": [{"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Bergqvist", "given": "Anders", "initials": "A"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2020-09-29", "journal": {"title": "Crit Care", "issn": "1466-609X", "issn-l": "1364-8535", "volume": "24", "issue": "1", "pages": "587"}, "abstract": null, "doi": "10.1186/s13054-020-03302-w", "pmid": "32993742", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-020-03302-w"}, {"db": "pmc", "key": "PMC7523248"}], "notes": [], "created": "2020-10-30T11:37:02.479Z", "modified": "2022-02-14T07:31:25.838Z"}, {"entity": "publication", "iuid": "4eb9d1599aef4d0d8d35c472a8e20ea9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4eb9d1599aef4d0d8d35c472a8e20ea9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4eb9d1599aef4d0d8d35c472a8e20ea9"}}, "title": "A common model for the breathlessness experience", "authors": [{"family": "Finnegan", "given": "Sarah L", "initials": "SL"}, {"family": "Pattinson", "given": "Kyle T S", "initials": "KTS"}, {"family": "Sundh", "given": "Josefin", "initials": "J"}, {"family": "Sk\u00f6ld", "given": "Magnus", "initials": "M"}, {"family": "Janson", "given": "Christer", "initials": "C"}, {"family": "Blomberg", "given": "Anders", "initials": "A"}, {"family": "Sandberg", "given": "Jacob", "initials": "J"}, {"family": "Ekstr\u00f6m", "given": "Magnus", "initials": "M"}], "type": "posted-content", "published": "2020-09-29", "journal": {"title": "", "issn": null, "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1101/2020.09.29.20203943", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-10T04:31:13.835Z", "modified": "2021-06-10T04:31:13.835Z"}, {"entity": "publication", "iuid": "5ed913f6997047d098f6186a54cff8bb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5ed913f6997047d098f6186a54cff8bb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5ed913f6997047d098f6186a54cff8bb"}}, "title": "MAIT cell activation and dynamics associated with COVID-19 disease severity.", "authors": [{"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Gorin", "given": "Jean-Baptiste", "initials": "J"}, {"family": "Ponzetta", "given": "Andrea", "initials": "A"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Kammann", "given": "Tobias", "initials": "T"}, {"family": "Emg\u00e5rd", "given": "Johanna", "initials": "J"}, {"family": "Perez-Potti", "given": "Andr\u00e9", "initials": "A"}, {"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Karolinska COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Folkesson", "given": "Elin", "initials": "E"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}], "type": "journal article", "published": "2020-09-28", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "issn-l": "2470-9468", "volume": "5", "issue": "51", "pages": null}, "abstract": "Severe COVID-19 is characterized by excessive inflammation of the lower airways. The balance of protective versus pathological immune responses in COVID-19 is incompletely understood. Mucosa-associated invariant T (MAIT) cells are antimicrobial T cells that recognize bacterial metabolites, and can also function as innate-like sensors and mediators of antiviral responses. Here, we investigated the MAIT cell compartment in COVID-19 patients with moderate and severe disease, as well as in convalescence. We show profound and preferential decline in MAIT cells in the circulation of patients with active disease paired with strong activation. Furthermore, transcriptomic analyses indicated significant MAIT cell enrichment and pro-inflammatory IL-17A bias in the airways. Unsupervised analysis identified MAIT cell CD69 high and CXCR3low immunotypes associated with poor clinical outcome. MAIT cell levels normalized in the convalescent phase, consistent with dynamic recruitment to the tissues and later release back into the circulation when disease is resolved. These findings indicate that MAIT cells are engaged in the immune response against SARS-CoV-2 and suggest their possible involvement in COVID-19 immunopathogenesis.", "doi": "10.1126/sciimmunol.abe1670", "pmid": "32989174", "labels": {"Type: Journal article": null, "Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Genomics & transcriptomics": null, "Category: Health": null, "Category: Proteins": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "URL", "key": "https://covid19cellatlas.com/#/", "description": "Curated flow cytometry data are available for exploration via the Karolinska COVID-19 Immune Atlas"}, {"db": "URL", "key": "https://www.science.org/doi/10.1126/sciimmunol.abe1670#", "description": "Raw data available in the supplementary materials"}], "notes": [], "created": "2020-10-28T09:05:35.876Z", "modified": "2021-11-18T08:57:57.308Z"}, {"entity": "publication", "iuid": "308f9d1f08cb40baba508a70b7f74083", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/308f9d1f08cb40baba508a70b7f74083.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/308f9d1f08cb40baba508a70b7f74083"}}, "title": "Characteristics and short-term obstetric outcomes in a case series of 67 women test-positive for SARS-CoV-2 in Stockholm, Sweden.", "authors": [{"family": "Remaeus", "given": "Katarina", "initials": "K"}, {"family": "Savchenko", "given": "Julia", "initials": "J"}, {"family": "Brismar Wendel", "given": "Sophia", "initials": "S"}, {"family": "Brusell Gidl\u00f6f", "given": "Sebastian", "initials": "S"}, {"family": "Graner", "given": "Sophie", "initials": "S"}, {"family": "Jones", "given": "Elin", "initials": "E"}, {"family": "Molin", "given": "Johanna", "initials": "J"}, {"family": "Saltvedt", "given": "Sissel", "initials": "S"}, {"family": "Wallstr\u00f6m", "given": "Tove", "initials": "T"}, {"family": "Pettersson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2020-09-27", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "12", "pages": "1626-1631", "issn-l": "0001-6349"}, "abstract": "The Stockholm region was the first area in Sweden to be hit by the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The national guidelines on the care of women with a positive test for SARS-CoV-2 (detection with polymerase chain reaction [PCR]) recommend individualized antenatal care, mode of delivery based on obstetric considerations, and no routine separation of the mother and the newborn. Breastfeeding is encouraged, and although there is no specific recommendation regarding wearing a face mask to prevent viral transmission to the newborn while nursing, instructions are given to keep high hygiene standards. All studies based on cases tested on hospital admission will capture more women with pregnancy complications than in the general population. Our aim was to describe the clinical characteristics of SARS-CoV-2-positive women and their neonates, and to report short-term maternal and neonatal outcomes.\n\nA retrospective case series with data from medical records including all test-positive women (n = 67) who gave birth to 68 neonates from 19 March to 26 April 2020 in Stockholm, Sweden. Means, proportions and percentages were calculated for clinical characteristics and outcomes.\n\nThe mean age was 32 years, 40% were nulliparous and 61% were overweight or obese. Further, 15% had diabetes and 21% a hypertensive disease. Seventy percent of the women had a vaginal birth. Preterm delivery occurred in 19% of the women. The preterm deliveries were mostly medically indicated, including two women who were delivered preterm due to severe coronavirus disease 19 (COVID-19), corresponding to 15% of the preterm births. Four women (6%) were admitted to the intensive care unit postpartum but there were no maternal deaths. There were two perinatal deaths (one stillbirth and one neonatal death). Three neonates were PCR-positive for SARS-CoV-2 after birth.\n\nIn this case series of 67 women testing positive for SARS-CoV-2 with clinical presentations ranging from asymptomatic to manifest COVID-19 disease, few women presented with severe COVID-19 illness. The majority had a vaginal birth at term with a healthy neonate that was negative for SARS-CoV-2.", "doi": "10.1111/aogs.14006", "pmid": "32981033", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7537005"}], "notes": [], "created": "2020-11-18T17:02:04.781Z", "modified": "2021-02-26T08:45:48.016Z"}, {"entity": "publication", "iuid": "9175d3585166411d81c584242c79bed8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9175d3585166411d81c584242c79bed8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9175d3585166411d81c584242c79bed8"}}, "title": "Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation.", "authors": [{"family": "Wallentin", "given": "Lars", "initials": "L"}, {"family": "Lindb\u00e4ck", "given": "Johan", "initials": "J"}, {"family": "Eriksson", "given": "Niclas", "initials": "N"}, {"family": "Hijazi", "given": "Ziad", "initials": "Z"}, {"family": "Eikelboom", "given": "John W", "initials": "JW"}, {"family": "Ezekowitz", "given": "Michael D", "initials": "MD"}, {"family": "Granger", "given": "Christopher B", "initials": "CB"}, {"family": "Lopes", "given": "Renato D", "initials": "RD"}, {"family": "Yusuf", "given": "Salim", "initials": "S"}, {"family": "Oldgren", "given": "Jonas", "initials": "J"}, {"family": "Siegbahn", "given": "Agneta", "initials": "A"}], "type": "journal article", "published": "2020-09-27", "journal": {"title": "Eur Heart J", "issn": "1522-9645", "volume": "41", "issue": "41", "pages": "4037-4046", "issn-l": "0195-668X"}, "abstract": "The global COVID-19 pandemic is caused by the SARS-CoV-2 virus entering human cells using angiotensin-converting enzyme 2 (ACE2) as a cell surface receptor. ACE2 is shed to the circulation, and a higher plasma level of soluble ACE2 (sACE2) might reflect a higher cellular expression of ACE2. The present study explored the associations between sACE2 and clinical factors, cardiovascular biomarkers, and genetic variability.\r\n\r\nPlasma and DNA samples were obtained from two international cohorts of elderly patients with atrial fibrillation (n = 3999 and n = 1088). The sACE2 protein level was measured by the Olink Proteomics\u00ae Multiplex CVD II96 \u00d7 96 panel. Levels of the biomarkers high-sensitive cardiac troponin T (hs-cTnT), N-terminal probrain natriuretic peptide (NT-proBNP), growth differentiation factor 15 (GDF-15), C-reactive protein, interleukin-6, D-dimer, and cystatin-C were determined by immunoassays. Genome-wide association studies were performed by Illumina chips. Higher levels of sACE2 were statistically significantly associated with male sex, cardiovascular disease, diabetes, and older age. The sACE2 level was most strongly associated with the levels of GDF-15, NT-proBNP, and hs-cTnT. When adjusting for these biomarkers, only male sex remained associated with sACE2. We found no statistically significant genetic regulation of the sACE2 level.\r\n\r\nMale sex and clinical or biomarker indicators of biological ageing, cardiovascular disease, and diabetes are associated with higher sACE2 levels. The levels of GDF-15 and NT-proBNP, which are associated both with the sACE2 level and a higher risk for mortality and cardiovascular disease, might contribute to better identification of risk for severe COVID-19 infection.", "doi": "10.1093/eurheartj/ehaa697", "pmid": "32984892", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "5912214"}, {"db": "pmc", "key": "PMC7543499"}], "notes": [], "created": "2020-11-17T18:09:17.932Z", "modified": "2021-02-26T08:45:48.463Z"}, {"entity": "publication", "iuid": "eb89850b924e4388a4b97ddead5e4fde", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb89850b924e4388a4b97ddead5e4fde.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb89850b924e4388a4b97ddead5e4fde"}}, "title": "Sex Differences in Reported Adverse Drug Reactions to COVID-19 Drugs in a Global Database of Individual Case Safety Reports.", "authors": [{"family": "Zekarias", "given": "Alem", "initials": "A"}, {"family": "Watson", "given": "Sarah", "initials": "S"}, {"family": "Vidlin", "given": "Sara Hedfors", "initials": "SH"}, {"family": "Grundmark", "given": "Birgitta", "initials": "B"}], "type": "journal article", "published": "2020-09-25", "journal": {"title": "Drug Saf", "issn": "1179-1942", "volume": "43", "issue": "12", "pages": "1309-1314", "issn-l": "0114-5916"}, "abstract": "In late 2019, a new coronavirus-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-was discovered in Wuhan, China, and the World Health Organization later declared coronavirus disease 2019 (COVID-19) a pandemic. Numerous drugs have been repurposed and investigated for therapeutic effectiveness in the disease, including those from \"Solidarity,\" an international clinical trial (azithromycin, chloroquine, hydroxychloroquine, the fixed combination lopinavir/ritonavir, and remdesivir).\n\nOur objective was to evaluate adverse drug reaction (ADR) reporting for drugs when used in the treatment of COVID-19 compared with use for other indications, specifically focussing on sex differences.\n\nWe extracted reports on COVID-19-specific treatments from the global ADR database, VigiBase, using an algorithm developed to identify reports that listed COVID-19 as the indication. The Solidarity trial drugs were included, as were any drugs reported \u2265 100 times. We performed a descriptive comparison of reports for the same drugs used in non-COVID-19 indications. The data lock point date was 7 June 2020.\n\nIn total, 2573 reports were identified for drugs used in the treatment of COVID-19. In order of frequency, the most reported ADRs were electrocardiogram QT-prolonged, diarrhoea, nausea, hepatitis, and vomiting in males and diarrhoea, electrocardiogram QT-prolonged, nausea, vomiting, and upper abdominal pain in females. Other hepatic and kidney-related events were included in the top ten ADRs in males, whereas no hepatic or renal terms were reported for females. COVID-19-related reporting patterns differed from non-pandemic reporting for these drugs.\n\nReview of a global database of suspected ADR reports revealed sex differences in the reporting patterns for drugs used in the treatment of COVID-19. Patterns of ADR sex differences need further elucidation.", "doi": "10.1007/s40264-020-01000-8", "pmid": "32978702", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40264-020-01000-8"}, {"db": "pmc", "key": "PMC7518652"}], "notes": [], "created": "2020-11-22T09:50:11.774Z", "modified": "2020-11-27T12:40:03.156Z"}, {"entity": "publication", "iuid": "3ecce14ec16245e3bf05acf13930cd8c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ecce14ec16245e3bf05acf13930cd8c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ecce14ec16245e3bf05acf13930cd8c"}}, "title": "Public awareness, emotional reactions and human mobility in response to the COVID-19 outbreak in China - a population-based ecological study.", "authors": [{"family": "Li", "given": "Yuchen", "initials": "Y"}, {"family": "Zeng", "given": "Yu", "initials": "Y"}, {"family": "Liu", "given": "Guangdi", "initials": "G"}, {"family": "Lu", "given": "Donghao", "initials": "D"}, {"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Qiu", "given": "Jianqing", "initials": "J"}, {"family": "Zhang", "given": "Chao", "initials": "C"}, {"family": "Fall", "given": "Katja", "initials": "K"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Zhang", "given": "Wei", "initials": "W"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "journal article", "published": "2020-09-25", "journal": {"title": "Psychol Med", "issn": "1469-8978", "volume": null, "issue": null, "pages": "1-8", "issn-l": "0033-2917"}, "abstract": "The outbreak of COVID-19 generated severe emotional reactions, and restricted mobility was a crucial measure to reduce the spread of the virus. This study describes the changes in public emotional reactions and mobility patterns in the Chinese population during the COVID-19 outbreak.\n\nWe collected data on public emotional reactions in response to the outbreak through Weibo, the Chinese Twitter, between 1st January and 31st March 2020. Using anonymized location-tracking information, we analyzed the daily mobility patterns of approximately 90% of Sichuan residents.\n\nThere were three distinct phases of the emotional and behavioral reactions to the COVID-19 outbreak. The alarm phase (19th-26th January) was a restriction-free period, characterized by few new daily cases, but a large amount public negative emotions [the number of negative comments per Weibo post increased by 246.9 per day, 95% confidence interval (CI) 122.5-371.3], and a substantial increase in self-limiting mobility (from 45.6% to 54.5%, changing by 1.5% per day, 95% CI 0.7%-2.3%). The epidemic phase (27th January-15th February) exhibited rapidly increasing numbers of new daily cases, decreasing expression of negative emotions (a decrease of 27.3 negative comments per post per day, 95% CI -40.4 to -14.2), and a stabilized level of self-limiting mobility. The relief phase (16th February-31st March) had a steady decline in new daily cases and decreasing levels of negative emotion and self-limiting mobility.\n\nDuring the COVID-19 outbreak in China, the public's emotional reaction was strongest before the actual peak of the outbreak and declined thereafter. The change in human mobility patterns occurred before the implementation of restriction orders, suggesting a possible link between emotion and behavior.", "doi": "10.1017/S003329172000375X", "pmid": "32972473", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S003329172000375X"}, {"db": "pmc", "key": "PMC7542325"}], "notes": [], "created": "2020-12-03T15:07:39.951Z", "modified": "2021-02-26T08:45:48.088Z"}, {"entity": "publication", "iuid": "43f6cc5c2db44f8d9539cdc08d15ddee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/43f6cc5c2db44f8d9539cdc08d15ddee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/43f6cc5c2db44f8d9539cdc08d15ddee"}}, "title": "Presence of hyaluronan in lung alveoli in severe Covid-19 - an opening for new treatment options?", "authors": [{"family": "Hellman", "given": "Urban", "initials": "U"}, {"family": "Karlsson", "given": "Mats G", "initials": "MG"}, {"family": "Engstr\u00f6m-Laurent", "given": "Anna", "initials": "A"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "Dorofte", "given": "Luiza", "initials": "L"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Laurent", "given": "Claude", "initials": "C"}, {"family": "Blomberg", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-09-25", "journal": {"title": "J Biol Chem", "issn": "1083-351X", "volume": "295", "issue": "45", "pages": "15418-15422", "issn-l": "0021-9258"}, "abstract": "Severe corona virus disease 2019 (Covid-19) is characterized by inflammation of the lungs with increasing respiratory impairment. In fatal Covid-19, lungs at autopsy have been filled with a clear liquid jelly. However, the nature of this finding has not yet been determined.The aim of the study was to demonstrate if the lungs of fatal Covid-19 contain hyaluronan as it is associated with inflammation and acute respiratory distress syndrome (ARDS) and may have the appearance of liquid jelly.Lung tissue obtained at autopsy from three deceased Covid-19 patients was processed for hyaluronan histochemistry using a direct staining method and compared with staining in normal lung tissue.Stainings confirmed that hyaluronan is obstructing alveoli with presence in exudate and plugs, as well as in thickened perialveolar interstitium. In contrast, normal lungs only showed hyaluronan in intact alveolar walls and perivascular tissue. This is the first study to confirm prominent hyaluronan exudates in the alveolar spaces of Covid-19 lungs, supporting the notion that the macromolecule is involved in ARDS caused by SARS-CoV-2. The present finding may open up for new treatment options in severe Covid-19, aiming at reducing the presence and production of hyaluronan in the lungs.", "doi": "10.1074/jbc.AC120.015967", "pmid": "32978255", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Imaging": null}, "xrefs": [{"db": "NA", "key": "Provided in the article: color light micrographs of autopsy lung tissue from the three Covid-19 cases", "description": null}], "notes": [], "created": "2020-10-28T09:07:27.329Z", "modified": "2021-02-26T08:45:36.597Z"}, {"entity": "publication", "iuid": "a61e49761bfe4a18b81bb94f09c05300", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a61e49761bfe4a18b81bb94f09c05300.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a61e49761bfe4a18b81bb94f09c05300"}}, "title": "Inactivation of SARS-CoV-2 and HCoV-229E in vitro by ColdZyme\u00ae a medical device mouth spray against the common cold.", "authors": [{"family": "Gudmundsdottir", "given": "\u00c1g\u00fasta", "initials": "\u00c1"}, {"family": "Scheving", "given": "Reynir", "initials": "R"}, {"family": "Lindberg", "given": "Fredrik", "initials": "F"}, {"family": "Stefansson", "given": "Bjarki", "initials": "B"}], "type": "journal article", "published": "2020-09-25", "journal": {"title": "J Med Virol", "issn": "1096-9071", "volume": null, "issue": null, "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic calls for effective and safe treatments. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 actively replicates in the throat, unlike SARS-CoV, and shows high pharyngeal viral shedding even in patients with mild symptoms of the disease. HCoV-229E is one of four coronaviruses causing the common cold. In this study, the efficacy of ColdZyme\u00ae (CZ-MD), a medical device mouth spray, was tested against SARS-CoV-2 and HCoV-229E in vitro. The CZ-MD provides a protective glycerol barrier containing cod trypsin as an ancillary component. Combined, these ingredients can inactivate common cold viruses in the throat and mouth. The CZ-MD is believed to act on the viral surface proteins that would perturb their entry pathway into cells. The efficacy and safety of the CZ-MD have been demonstrated in clinical trials on the common cold.\n\nThe ability of the CZ-MD to inactivate SARS-CoV-2 and HCoV-229E was tested using an in vitro virucidal suspension test (ASTM E1052).\n\nCZ-MD inactivated SARS-CoV-2 by 98.3% and HCoV-229E by 99.9%.\n\nCZ-MD mouth spray can inactivate the respiratory coronaviruses SARS-CoV-2 and HCoV-229E in vitro. Although the in vitro results presented cannot be directly translated into clinical efficacy, the study indicates that CZ-MD might offer a protective barrier against SARS-CoV-2 and a decreased risk of COVID-19 transmission.", "doi": "10.1002/jmv.26554", "pmid": "32975843", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7537187"}], "notes": [], "created": "2020-12-03T09:53:18.160Z", "modified": "2021-02-26T08:46:13.408Z"}, {"entity": "publication", "iuid": "f07eeb1d98f44403815c952ee55045c3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f07eeb1d98f44403815c952ee55045c3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f07eeb1d98f44403815c952ee55045c3"}}, "title": "Impact of COVID-19 on Online Gambling - A General Population Survey During the Pandemic.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-09-25", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "11", "issue": null, "pages": "568543"}, "abstract": "The COVID-19 pandemic may have severe impact on mental health, and concerns have been raised about potentially increased online behavior and possibly increased gambling problems, such as in sports bettors at risk of transfer to even riskier forms of gambling during sports lock-down. Given the need for objective data about gambling behavior during the pandemic, the present analysis, from a project assessing online gambling in Sweden, aimed to study past-30-day gambling patterns in online gamblers in Sweden. The study, carried out in May, 2020, during the pandemic and its restrictions on society, included past-year online gamblers ( N = 997). Past-30-day gambling for several gambling types was lower compared to a previous study in online gamblers in the same setting, while online non-sports gambling remained at high levels. Those reporting sports betting even during a period with decreased sports betting occasions proved to have markedly higher gambling problems. COVID-19 may alter gambling behaviors, and online gamblers who maintain or initiate gambling types theoretically reduced by the crisis may represent a group at particular risk.", "doi": "10.3389/fpsyg.2020.568543", "pmid": "33101137", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7546777"}], "notes": [], "created": "2020-12-01T15:26:58.330Z", "modified": "2022-11-10T06:23:11.417Z"}, {"entity": "publication", "iuid": "02f623854eac45c9a12385a468181dfb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02f623854eac45c9a12385a468181dfb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02f623854eac45c9a12385a468181dfb"}}, "title": "Using volunteered geographic information to assess mobility in the early phases of the COVID-19 pandemic: a cross-city time series analysis of 41 cities in 22 countries from March 2nd to 26th 2020.", "authors": [{"family": "Vannoni", "given": "Matia", "initials": "M"}, {"family": "McKee", "given": "Martin", "initials": "M"}, {"family": "Semenza", "given": "Jan C", "initials": "JC"}, {"family": "Bonell", "given": "Chris", "initials": "C"}, {"family": "Stuckler", "given": "David", "initials": "D"}], "type": "journal article", "published": "2020-09-23", "journal": {"title": "Global Health", "issn": "1744-8603", "issn-l": "1744-8603", "volume": "16", "issue": "1", "pages": "85"}, "abstract": "Restricting mobility is a central aim for lowering contact rates and preventing COVID-19 transmission. Yet the impact on mobility of different non-pharmaceutical countermeasures in the earlier stages of the pandemic is not well-understood.\r\n\r\nTrends were evaluated using Citymapper's mobility index covering 2nd to 26th March 2020, expressed as percentages of typical usage periods from 0% as the lowest and 100% as normal. China and India were not covered. Multivariate fixed effects models were used to estimate the association of policies restricting movement on mobility before and after their introduction. Policy restrictions were assessed using the Oxford COVID-19 Government Response Stringency Index as well as measures coding the timing and degree of school and workplace closures, transport restrictions, and cancellation of mass gatherings.\r\n\r\n41 cities worldwide.\r\n\r\nCitymapper's mobility index.\r\n\r\nMobility declined in all major cities throughout March. Larger declines were seen in European than Asian cities. The COVID-19 Government Response Stringency Index was strongly associated with declines in mobility (r = - 0.75, p < 0.001). After adjusting for time-trends, we observed that implementing non-pharmaceutical countermeasures was associated with a decline of mobility of 10.0% for school closures (95% CI: 4.36 to 15.7%), 15.0% for workplace closures (95% CI: 10.2 to 19.8%), 7.09% for cancelling public events (95% CI: 1.98 to 12.2%), 18.0% for closing public transport (95% CI: 6.74 to 29.2%), 13.3% for restricting internal movements (95% CI: 8.85 to 17.8%) and 5.30% for international travel controls (95% CI: 1.69 to 8.90). In contrast, as expected, there was no association between population mobility changes and fiscal or monetary measures or emergency healthcare investment.\r\n\r\nUnderstanding the effect of public policy on mobility in the early stages is crucial to slowing and reducing COVID-19 transmission. By using Citymapper's mobility index, this work provides the first evidence about trends in mobility and the impacts of different policy interventions, suggesting that closure of public transport, workplaces and schools are particularly impactful.", "doi": "10.1186/s12992-020-00598-9", "pmid": "32967691", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12992-020-00598-9"}, {"db": "pmc", "key": "PMC7509494"}], "notes": [], "created": "2020-12-03T15:10:35.960Z", "modified": "2022-11-10T06:24:31.850Z"}, {"entity": "publication", "iuid": "b5ca3e7c61b14b03b1d97ab34f663163", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5ca3e7c61b14b03b1d97ab34f663163.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5ca3e7c61b14b03b1d97ab34f663163"}}, "title": "Small droplet emission in exhaled breath during different breathing manoeuvres: Implications for clinical lung function testing during COVID-19.", "authors": [{"family": "Greening", "given": "Neil J", "initials": "NJ"}, {"family": "Larsson", "given": "Per", "initials": "P"}, {"family": "Ljungstr\u00f6m", "given": "Evert", "initials": "E"}, {"family": "Siddiqui", "given": "Salman", "initials": "S"}, {"family": "Olin", "given": "Anna-Carin", "initials": "AC"}], "type": "letter", "published": "2020-09-23", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": null, "issue": null, "issn-l": "0105-4538"}, "abstract": null, "doi": "10.1111/all.14596", "pmid": "32966612", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7537081"}], "notes": [], "created": "2020-12-03T09:05:39.572Z", "modified": "2020-12-03T09:05:39.584Z"}, {"entity": "publication", "iuid": "018d04d578e04e89989323730b746c3f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/018d04d578e04e89989323730b746c3f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/018d04d578e04e89989323730b746c3f"}}, "title": "Massive and rapid COVID-19 testing is feasible by extraction-free SARS-CoV-2 RT-PCR.", "authors": [{"family": "Smyrlaki", "given": "Ioanna", "initials": "I"}, {"family": "Ekman", "given": "Martin", "initials": "M"}, {"family": "Lentini", "given": "Antonio", "initials": "A", "orcid": "0000-0003-1239-5495", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8c1f3989ef84f6d9803fb30b3014dc4.json"}}, {"family": "Rufino de Sousa", "given": "Nuno", "initials": "N", "orcid": "0000-0002-0670-9788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1cb037a9e7f44a489dd84d6f5ba513d7.json"}}, {"family": "Papanicolaou", "given": "Natali", "initials": "N"}, {"family": "Vondracek", "given": "Martin", "initials": "M"}, {"family": "Aarum", "given": "Johan", "initials": "J"}, {"family": "Safari", "given": "Hamzah", "initials": "H"}, {"family": "Muradrasoli", "given": "Shaman", "initials": "S"}, {"family": "Rothfuchs", "given": "Antonio Gigliotti", "initials": "AG", "orcid": "0000-0001-6001-7240", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00102c49ae2d41828272e850cd551c9f.json"}}, {"family": "Albert", "given": "Jan", "initials": "J", "orcid": "0000-0001-9020-0521", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79a6c7eedadb4a1e8c6fd7b8b522a8e3.json"}}, {"family": "H\u00f6gberg", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0003-2715-7887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11deae9980bd4bf6859b25de2b0c3908.json"}}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-7021-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9eef54f4e0534805b173cfae62a75d55.json"}}], "type": "comparative study", "published": "2020-09-23", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "11", "issue": "1", "pages": "4812"}, "abstract": "Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is commonly diagnosed by reverse transcription polymerase chain reaction (RT-PCR) to detect viral RNA in patient samples, but RNA extraction constitutes a major bottleneck in current testing. Methodological simplification could increase diagnostic availability and efficiency, benefitting patient care and infection control. Here, we describe methods circumventing RNA extraction in COVID-19 testing by performing RT-PCR directly on heat-inactivated or lysed samples. Our data, including benchmarking using 597 clinical patient samples and a standardised diagnostic system, demonstrate that direct RT-PCR is viable option to extraction-based tests. Using controlled amounts of active SARS-CoV-2, we confirm effectiveness of heat inactivation by plaque assay and evaluate various generic buffers as transport medium for direct RT-PCR. Significant savings in time and cost are achieved through RNA-extraction-free protocols that are directly compatible with established PCR-based testing pipelines. This could aid expansion of COVID-19 testing.", "doi": "10.1038/s41467-020-18611-5", "pmid": "32968075", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Diagnostics for virus": null}, "xrefs": [{"db": "pmc", "key": "PMC7511968"}, {"db": "pii", "key": "10.1038/s41467-020-18611-5"}], "notes": [], "created": "2020-10-30T12:04:36.610Z", "modified": "2023-06-19T15:01:27.658Z"}, {"entity": "publication", "iuid": "c9df8b74343c4af8870f002b5a1f4c99", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9df8b74343c4af8870f002b5a1f4c99.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9df8b74343c4af8870f002b5a1f4c99"}}, "title": "Association of SARS-CoV-2 Test Status and Pregnancy Outcomes.", "authors": [{"family": "Ahlberg", "given": "Mia", "initials": "M"}, {"family": "Neovius", "given": "Martin", "initials": "M"}, {"family": "Saltvedt", "given": "Sissel", "initials": "S"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Pettersson", "given": "Karin", "initials": "K"}, {"family": "Brandkvist", "given": "Clara", "initials": "C"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}], "type": "journal article", "published": "2020-09-23", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484", "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1001/jama.2020.19124", "pmid": "32965467", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "2771110"}, {"db": "pmc", "key": "PMC7512127"}], "notes": [], "created": "2020-11-18T17:03:47.315Z", "modified": "2021-02-26T08:45:48.707Z"}, {"entity": "publication", "iuid": "209ab7dba5694ea6a03b0ca5ab24a397", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/209ab7dba5694ea6a03b0ca5ab24a397.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/209ab7dba5694ea6a03b0ca5ab24a397"}}, "title": "Psychosocial emergency care in times of COVID-19: the Essen University Hospital concept for corona-infected patients, their relatives, and medical staff.", "authors": [{"family": "Rentrop", "given": "Vanessa", "initials": "V"}, {"family": "Schneider", "given": "Johanna Sophie", "initials": "JS"}, {"family": "B\u00e4uerle", "given": "Alexander", "initials": "A"}, {"family": "Junne", "given": "Florian", "initials": "F"}, {"family": "D\u00f6rrie", "given": "Nora", "initials": "N"}, {"family": "Skoda", "given": "Eva-Maria", "initials": "E"}, {"family": "Schedlowski", "given": "Manfred", "initials": "M"}, {"family": "Mallmann", "given": "Bernhard", "initials": "B"}, {"family": "Benecke", "given": "Anke-Verena", "initials": "A"}, {"family": "Kohler", "given": "Hannah", "initials": "H"}, {"family": "Gerigk", "given": "Monja", "initials": "M"}, {"family": "Teigelack", "given": "Per", "initials": "P"}, {"family": "Emler", "given": "Tobias", "initials": "T"}, {"family": "Scherbaum", "given": "Norbert", "initials": "N"}, {"family": "Gradl-Dietsch", "given": "Gertraud", "initials": "G"}, {"family": "Scheer", "given": "Karin", "initials": "K"}, {"family": "Teufel", "given": "Martin", "initials": "M"}], "type": "letter", "published": "2020-09-22", "journal": {"title": "Int Arch Occup Environ Health", "issn": "1432-1246", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Due to the SARS CoV-2-virus (COVID-19), anxiety, distress, and insecurity occur more frequently. In particular, infected individuals, their relatives, and medical staff face an increased risk of high psychological distress as a result of the ongoing pandemic. Thus, structured psychosocial emergency concepts are needed. The University hospital of Essen has taken up this challenge by creating the PEC concept to reduce psychosocial long-term consequences for infected patients, relatives, and medical staff at the university hospital. The concept includes professional medical as well as psychological support to convey constructive coping strategies and the provision of adequate tools such as the low-threshold online training program (CoPE It), which is accessible via the webpage www.cope-corona.de .", "doi": "10.1007/s00420-020-01580-z", "pmid": "32964313", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00420-020-01580-z"}, {"db": "pmc", "key": "PMC7508238"}], "notes": [], "created": "2020-12-03T09:23:51.961Z", "modified": "2022-11-10T06:25:29.610Z"}, {"entity": "publication", "iuid": "94fad26a33554d9aa598c2b1d08311fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/94fad26a33554d9aa598c2b1d08311fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/94fad26a33554d9aa598c2b1d08311fd"}}, "title": "Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19.", "authors": [{"family": "Kanberg", "given": "Nelly", "initials": "N"}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Price", "given": "Richard W", "initials": "RW"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2020-09-22", "journal": {"title": "Neurology", "issn": "1526-632X", "volume": "95", "issue": "12", "pages": "e1754-e1759", "issn-l": "0028-3878"}, "abstract": "To test the hypothesis that coronavirus disease 2019 (COVID-19) has an impact on the CNS by measuring plasma biomarkers of CNS injury.\n\nWe recruited 47 patients with mild (n = 20), moderate (n = 9), or severe (n = 18) COVID-19 and measured 2 plasma biomarkers of CNS injury by single molecule array, neurofilament light chain protein (NfL; a marker of intra-axonal neuronal injury) and glial fibrillary acidic protein (GFAp; a marker of astrocytic activation/injury), in samples collected at presentation and again in a subset after a mean of 11.4 days. Cross-sectional results were compared with results from 33 age-matched controls derived from an independent cohort.\n\nThe patients with severe COVID-19 had higher plasma concentrations of GFAp ( p = 0.001) and NfL (p < 0.001) than controls, while GFAp was also increased in patients with moderate disease (p = 0.03). In patients with severe disease, an early peak in plasma GFAp decreased on follow-up (p < 0.01), while NfL showed a sustained increase from first to last follow-up (p < 0.01), perhaps reflecting a sequence of early astrocytic response and more delayed axonal injury.\n\nWe show neurochemical evidence of neuronal injury and glial activation in patients with moderate and severe COVID-19. Further studies are needed to clarify the frequency and nature of COVID-19-related CNS damage and its relation to both clinically defined CNS events such as hypoxic and ischemic events and mechanisms more closely linked to systemic severe acute respiratory syndrome coronavirus 2 infection and consequent immune activation, as well as to evaluate the clinical utility of monitoring plasma NfL and GFAp in the management of this group of patients.", "doi": "10.1212/WNL.0000000000010111", "pmid": "32546655", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "NA", "key": "Researchers can apply for access to anonymized data", "description": null}], "notes": [], "created": "2020-10-30T11:38:14.005Z", "modified": "2021-02-26T08:45:03.162Z"}, {"entity": "publication", "iuid": "7853c20a2ac34fef9a21a1b25175065a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7853c20a2ac34fef9a21a1b25175065a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7853c20a2ac34fef9a21a1b25175065a"}}, "title": "Mitigation of the replication of SARS-CoV-2 by nitric oxide in vitro", "authors": [{"family": "Akaberi", "given": "Dario", "initials": "D"}, {"family": "Krambrich", "given": "Janina", "initials": "J"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Luni", "given": "Chen", "initials": "C"}, {"family": "Hedenstierna", "given": "G\u00f6ran", "initials": "G"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}, {"family": "Lennerstrand", "given": "Johan", "initials": "J"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "journal-article", "published": "2020-09-21", "journal": {"title": "Redox Biology", "issn": "2213-2317", "issn-l": "2213-2317", "volume": "37", "issue": null, "pages": "101734"}, "abstract": "The ongoing SARS-CoV-2 pandemic is a global public health emergency posing a high burden on nations' health care systems and economies. Despite the great effort put in the development of vaccines and specific treatments, no prophylaxis or effective therapeutics are currently available. Nitric oxide (NO) is a broad-spectrum antimicrobial and a potent vasodilator that has proved to be effective in reducing SARS-CoV replication and hypoxia in patients with severe acute respiratory syndrome. Given the potential of NO as treatment for SARS-CoV-2 infection, we have evaluated the in vitro antiviral effect of NO on SARS-CoV-2 replication. The NO-donor S-nitroso-N-acetylpenicillamine (SNAP) had a dose dependent inhibitory effect on SARS-CoV-2 replication, while the non S-nitrosated NAP was not active, as expected. Although the viral replication was not completely abolished (at 200 \u03bcM and 400 \u03bcM), SNAP delayed or completely prevented the development of viral cytopathic effect in treated cells, and the observed protective effect correlated with the level of inhibition of the viral replication. The capacity of the NO released from SNAP to covalently bind and inhibit SARS-CoV-2 3CL recombinant protease in vitro was also tested. The observed reduction in SARS-CoV-2 protease activity was consistent with S-nitrosation of the enzyme active site cysteine.", "doi": "10.1016/j.redox.2020.101734", "pmid": "33007504", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Drug discovery and repurposing of drugs": null, "Category: Imaging": null, "Category: Proteins": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.1016/j.redox.2020.101734", "description": "Supplementary data"}], "notes": [], "created": "2020-10-30T11:25:59.730Z", "modified": "2021-06-14T14:31:10.633Z"}, {"entity": "publication", "iuid": "755e672d6e4b461c92ec69293c239cf2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/755e672d6e4b461c92ec69293c239cf2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/755e672d6e4b461c92ec69293c239cf2"}}, "title": "Crisis Management by Journal Editors: Case of COVID-19.", "authors": [{"family": "Sorooshian", "given": "Shahryar", "initials": "S"}], "type": "journal article", "published": "2020-09-21", "journal": {"title": "J Korean Med Sci", "issn": "1598-6357", "volume": "35", "issue": "37", "pages": "e320", "issn-l": null}, "abstract": null, "doi": "10.3346/jkms.2020.35.e320", "pmid": "32959545", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "35.e320"}, {"db": "pmc", "key": "PMC7505727"}], "notes": [], "created": "2020-12-03T09:25:25.650Z", "modified": "2020-12-03T09:25:25.675Z"}, {"entity": "publication", "iuid": "b8e24bc4dbf245908a5bf678a0c3b0b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8e24bc4dbf245908a5bf678a0c3b0b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8e24bc4dbf245908a5bf678a0c3b0b9"}}, "title": "Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test.", "authors": [{"family": "De Marinis", "given": "Yang", "initials": "Y"}, {"family": "Sunnerhagen", "given": "Torgny", "initials": "T"}, {"family": "Bompada", "given": "Pradeep", "initials": "P"}, {"family": "Bl\u00e4ckberg", "given": "Anna", "initials": "A"}, {"family": "Yang", "given": "Runtao", "initials": "R"}, {"family": "Svensson", "given": "Joel", "initials": "J"}, {"family": "Ekstr\u00f6m", "given": "Ola", "initials": "O"}, {"family": "Eriksson", "given": "Karl-Fredrik", "initials": "K"}, {"family": "Hansson", "given": "Ola", "initials": "O"}, {"family": "Groop", "given": "Leif", "initials": "L"}, {"family": "Gon\u00e7alves", "given": "Isabel", "initials": "I"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2020-09-20", "journal": {"title": "Infect Ecol Epidemiol", "issn": "2000-8686", "issn-l": "2000-8686", "volume": "10", "issue": "1", "pages": "1821513"}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has created a global health- and economic crisis. Detection of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19 by serological methods is important to diagnose a current or resolved infection. In this study, we applied a rapid COVID-19 IgM/IgG antibody test and performed serology assessment of antibody response to SARS-CoV-2. In PCR-confirmed COVID-19 patients (n = 45), the total antibody detection rate is 92% in hospitalized patients and 79% in non-hospitalized patients. The total IgM and IgG detection is 63% in patients with <2 weeks from disease onset; 85% in non-hospitalized patients with >2 weeks disease duration; and 91% in hospitalized patients with >2 weeks disease duration. We also compared different blood sample types and suggest a higher sensitivity by serum/plasma over whole blood. Test specificity was determined to be 97% on 69 sera/plasma samples collected between 2016-2018. Our study provides a comprehensive validation of the rapid COVID-19 IgM/IgG serology test, and mapped antibody detection patterns in association with disease progress and hospitalization. Our results support that the rapid COVID-19 IgM/IgG test may be applied to assess the COVID-19 status both at the individual and at a population level.", "doi": "10.1080/20008686.2020.1821513", "pmid": "33062217", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Serology": null}, "xrefs": [{"db": "pii", "key": "1821513"}, {"db": "pmc", "key": "PMC7534290"}], "notes": [], "created": "2020-12-01T17:09:23.638Z", "modified": "2021-02-26T08:46:49.378Z"}, {"entity": "publication", "iuid": "b1f90548f04e4b07a655403478429adf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1f90548f04e4b07a655403478429adf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1f90548f04e4b07a655403478429adf"}}, "title": "COVID-19 healthcare demand and mortality in Sweden in response to non-pharmaceutical mitigation and suppression scenarios.", "authors": [{"family": "Sj\u00f6din", "given": "Henrik", "initials": "H"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}, {"family": "Br\u00e4nnstr\u00f6m", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Farooq", "given": "Zia", "initials": "Z"}, {"family": "Kriit", "given": "Hedi Katre", "initials": "HK"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "\u00c5str\u00f6m", "given": "Christofer", "initials": "C"}, {"family": "Thunberg", "given": "Johan", "initials": "J"}, {"family": "S\u00f6derquist", "given": "M\u00e5rten", "initials": "M"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}], "type": "journal article", "published": "2020-09-20", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "issn-l": "0300-5771", "volume": "49", "issue": "5", "pages": "1443-1453"}, "abstract": "While the COVID-19 outbreak in China now appears suppressed, Europe and the USA have become the epicentres, both reporting many more deaths than China. Responding to the pandemic, Sweden has taken a different approach aiming to mitigate, not suppress, community transmission, by using physical distancing without lockdowns. Here we contrast the consequences of different responses to COVID-19 within Sweden, the resulting demand for care, intensive care, the death tolls and the associated direct healthcare related costs.\r\n\r\nWe used an age-stratified health-care demand extended SEIR (susceptible, exposed, infectious, recovered) compartmental model for all municipalities in Sweden, and a radiation model for describing inter-municipality mobility. The model was calibrated against data from municipalities in the Stockholm healthcare region.\r\n\r\nOur scenario with moderate to strong physical distancing describes well the observed health demand and deaths in Sweden up to the end of May 2020. In this scenario, the intensive care unit (ICU) demand reaches the pre-pandemic maximum capacity just above 500 beds. In the counterfactual scenario, the ICU demand is estimated to reach \u223c20 times higher than the pre-pandemic ICU capacity. The different scenarios show quite different death tolls up to 1 September, ranging from 5000 to 41 000, excluding deaths potentially caused by ICU shortage. Additionally, our statistical analysis of all causes excess mortality indicates that the number of deaths attributable to COVID-19 could be increased by 40% (95% confidence interval: 0.24, 0.57).\r\n\r\nThe results of this study highlight the impact of different combinations of non-pharmaceutical interventions, especially moderate physical distancing in combination with more effective isolation of infectious individuals, on reducing deaths, health demands and lowering healthcare costs. In less effective mitigation scenarios, the demand on ICU beds would rapidly exceed capacity, showing the tight interconnection between the healthcare demand and physical distancing in the society. These findings have relevance for Swedish policy and response to the COVID-19 pandemic and illustrate the importance of maintaining the level of physical distancing for a longer period beyond the study period to suppress or mitigate the impacts from the pandemic.", "doi": "10.1093/ije/dyaa121", "pmid": "32954400", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "5909271"}, {"db": "pmc", "key": "PMC7543571"}], "notes": [], "created": "2020-12-03T09:31:56.254Z", "modified": "2022-11-10T06:27:58.330Z"}, {"entity": "publication", "iuid": "865012848aa3469da99c9e119fb80623", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/865012848aa3469da99c9e119fb80623.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/865012848aa3469da99c9e119fb80623"}}, "title": "COVID Isolation Eating Scale (CIES): Analysis of the impact of confinement in eating disorders and obesity-A collaborative international study.", "authors": [{"family": "Fern\u00e1ndez-Aranda", "given": "Fernando", "initials": "F"}, {"family": "Mungu\u00eda", "given": "Lucero", "initials": "L"}, {"family": "Mestre-Bach", "given": "Gemma", "initials": "G"}, {"family": "Steward", "given": "Trevor", "initials": "T"}, {"family": "Etxandi", "given": "Mikel", "initials": "M"}, {"family": "Baenas", "given": "Isabel", "initials": "I"}, {"family": "Granero", "given": "Roser", "initials": "R"}, {"family": "S\u00e1nchez", "given": "Isabel", "initials": "I"}, {"family": "Ortega", "given": "Emilio", "initials": "E"}, {"family": "Andreu", "given": "Alba", "initials": "A"}, {"family": "Moize", "given": "Violeta L", "initials": "VL"}, {"family": "Fern\u00e1ndez-Real", "given": "Jose M", "initials": "JM"}, {"family": "Tinahones", "given": "Francisco J", "initials": "FJ"}, {"family": "Dieg\u00fcez", "given": "Carlos", "initials": "C"}, {"family": "Fr\u00fchbeck", "given": "Gema", "initials": "G"}, {"family": "Le Grange", "given": "Daniel", "initials": "D"}, {"family": "Tchanturia", "given": "Kate", "initials": "K"}, {"family": "Karwautz", "given": "Andreas", "initials": "A"}, {"family": "Zeiler", "given": "Michael", "initials": "M"}, {"family": "Favaro", "given": "Angela", "initials": "A"}, {"family": "Claes", "given": "Laurence", "initials": "L"}, {"family": "Luyckx", "given": "Koen", "initials": "K"}, {"family": "Shekriladze", "given": "Ia", "initials": "I"}, {"family": "Serrano-Troncoso", "given": "Eduardo", "initials": "E"}, {"family": "Rangil", "given": "Teresa", "initials": "T"}, {"family": "Meler", "given": "Maria Eulalia Loran", "initials": "MEL"}, {"family": "Soriano-Pacheco", "given": "Jose", "initials": "J"}, {"family": "Carceller-Sindreu", "given": "Mar", "initials": "M"}, {"family": "Bujalance-Arguijo", "given": "Sara", "initials": "S"}, {"family": "Lozano", "given": "Meritxell", "initials": "M"}, {"family": "Linares", "given": "Raquel", "initials": "R"}, {"family": "Gudiol", "given": "Carlota", "initials": "C"}, {"family": "Carratala", "given": "Jordi", "initials": "J"}, {"family": "Sanchez-Gonzalez", "given": "Jessica", "initials": "J"}, {"family": "Machado", "given": "Paulo Pp", "initials": "PP"}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "T\u00fary", "given": "Ferenc", "initials": "F"}, {"family": "P\u00e1szthy", "given": "Bea", "initials": "B"}, {"family": "Stein", "given": "Daniel", "initials": "D"}, {"family": "Papezov\u00e1", "given": "Hana", "initials": "H"}, {"family": "Bax", "given": "Brigita", "initials": "B"}, {"family": "Borisenkov", "given": "Mikhail F", "initials": "MF"}, {"family": "Popov", "given": "Sergey V", "initials": "SV"}, {"family": "Kim", "given": "Youl-Ri", "initials": "YR"}, {"family": "Nakazato", "given": "Michiko", "initials": "M"}, {"family": "Godart", "given": "Nathalie", "initials": "N"}, {"family": "van Voren", "given": "Robert", "initials": "R"}, {"family": "Ilnytska", "given": "Tetiana", "initials": "T"}, {"family": "Chen", "given": "Jue", "initials": "J"}, {"family": "Rowlands", "given": "Katie", "initials": "K"}, {"family": "Treasure", "given": "Janet", "initials": "J"}, {"family": "Jim\u00e9nez-Murcia", "given": "Susana", "initials": "S"}], "type": "journal article", "published": "2020-09-20", "journal": {"title": "Eur Eat Disord Rev", "issn": "1099-0968", "volume": null, "issue": null, "issn-l": null}, "abstract": "Confinement during the COVID-19 pandemic is expected to have a serious and complex impact on the mental health of patients with an eating disorder (ED) and of patients with obesity. The present manuscript has the following aims: (1) to analyse the psychometric properties of the COVID Isolation Eating Scale (CIES), (2) to explore changes that occurred due to confinement in eating symptomatology; and (3) to explore the general acceptation of the use of telemedicine during confinement. The sample comprised 121 participants (87 ED patients and 34 patients with obesity) recruited from six different centres. Confirmatory Factor Analyses (CFA) tested the rational-theoretical structure of the CIES. Adequate goodness-of-fit was obtained for the confirmatory factor analysis, and Cronbach alpha values ranged from good to excellent. Regarding the effects of confinement, positive and negative impacts of the confinement depends of the eating disorder subtype. Patients with anorexia nervosa (AN) and with obesity endorsed a positive response to treatment during confinement, no significant changes were found in bulimia nervosa (BN) patients, whereas Other Specified Feeding or Eating Disorder (OSFED) patients endorsed an increase in eating symptomatology and in psychopathology. Furthermore, AN patients expressed the greatest dissatisfaction and accommodation difficulty with remote therapy when compared with the previously provided face-to-face therapy. The present study provides empirical evidence on the psychometric robustness of the CIES tool and shows that a negative confinement impact was associated with ED subtype, whereas OSFED patients showed the highest impairment in eating symptomatology and in psychopathology.", "doi": "10.1002/erv.2784", "pmid": "32954595", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7537123"}], "notes": [], "created": "2020-12-03T09:30:37.325Z", "modified": "2020-12-03T09:30:37.348Z"}, {"entity": "publication", "iuid": "dcbf0bc0b92644a78d80a9dc708e6f34", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dcbf0bc0b92644a78d80a9dc708e6f34.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dcbf0bc0b92644a78d80a9dc708e6f34"}}, "title": "Sex differences in severity and mortality from COVID-19: are males more vulnerable?", "authors": [{"family": "Pradhan", "given": "Ajay", "initials": "A"}, {"family": "Olsson", "given": "Per-Erik", "initials": "PE"}], "type": "journal article", "published": "2020-09-18", "journal": {"title": "Biol Sex Differ", "issn": "2042-6410", "volume": "11", "issue": "1", "pages": "53", "issn-l": "2042-6410"}, "abstract": "Coronavirus disease 2019 (COVID-19) has shown high infection and mortality rates all over the world, and despite the global efforts, there is so far no specific therapy available for COVID-19. Interestingly, while the severity and mortality of COVID-19 are higher in males than in females, the underlying molecular mechanisms are unclear. In this review, we explore sex-related differences that may be contributing factors to the observed male-biased mortality from COVID-19. Males are considered the weaker sex in aspects related to endurance and infection control. Studies show that viral RNA clearance is delayed in males with COVID-19. A recent study has indicated that the testis can harbor coronavirus, and consequently, males show delayed viral clearance. However, the role of testis involvement in COVID-19 severity and mortality needs further research. Males and females show a distinct difference in immune system responses with females eliciting stronger immune responses to pathogens. This difference in immune system responses may be a major contributing factor to viral load, disease severity, and mortality. In addition, differences in sex hormone milieus could also be a determinant of viral infections as estrogen has immunoenhancing effects while testosterone has immunosuppressive effects. The sex-specific severity of COVID-19 infections indicates that further research on understanding the sex differences is needed. Inclusion of both males and females in basic research and clinical trials is required to provide critical information on sex-related differences that may help to better understand disease outcome and therapy.", "doi": "10.1186/s13293-020-00330-7", "pmid": "32948238", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13293-020-00330-7"}, {"db": "pmc", "key": "PMC7498997"}], "notes": [], "created": "2020-11-27T12:42:10.704Z", "modified": "2020-12-03T15:25:40.954Z"}, {"entity": "publication", "iuid": "17096ef2059d48928978ad8b31f503c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/17096ef2059d48928978ad8b31f503c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/17096ef2059d48928978ad8b31f503c5"}}, "title": "Death associated with coronavirus (COVID-19) infection in individuals with severe mental disorders in Sweden during the early months of the outbreak \u2013 a exploratory cross-sectional analysis of a population-based register study", "authors": [{"family": "Maripuu", "given": "Martin", "initials": "M", "orcid": "0000-0001-7868-8894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f85873e152d421eba74e23054d0ff1e.json"}}, {"family": "Bendix", "given": "Marie", "initials": "M", "orcid": "0000-0001-8901-166X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bbc1ba16f8c54e4e98e833c7066cf410.json"}}, {"family": "\u00d6hlund", "given": "Louise", "initials": "L", "orcid": "0000-0001-8271-5058", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c5008f4a48142269efb983389b805d0.json"}}, {"family": "Widerstr\u00f6m", "given": "Micael", "initials": "M", "orcid": "0000-0002-1483-4255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ad36fa63a334e3b91499527bb6d5659.json"}}, {"family": "Werneke", "given": "Ursula", "initials": "U", "orcid": "0000-0002-5023-3254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eed3b002ddb4cbba141cbfdc8d3f032.json"}}], "type": "posted-content", "published": "2020-09-18", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.09.14.20193987", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-14T06:40:14.574Z", "modified": "2022-11-22T05:52:46.830Z"}, {"entity": "publication", "iuid": "18b57d426c8641fa8ffe2f8ea572a873", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18b57d426c8641fa8ffe2f8ea572a873.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18b57d426c8641fa8ffe2f8ea572a873"}}, "title": "Community knowledge, perceptions and practices around COVID-19 in Sierra Leone: a nationwide, cross-sectional survey.", "authors": [{"family": "Sengeh", "given": "Paul", "initials": "P"}, {"family": "Jalloh", "given": "Mohammad B", "initials": "MB"}, {"family": "Webber", "given": "Nance", "initials": "N"}, {"family": "Ngobeh", "given": "Ibrahim", "initials": "I"}, {"family": "Samba", "given": "Thomas", "initials": "T"}, {"family": "Thomas", "given": "Harold", "initials": "H"}, {"family": "Nordenstedt", "given": "Helena", "initials": "H"}, {"family": "Winters", "given": "Maike", "initials": "M"}], "type": "journal article", "published": "2020-09-17", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "10", "issue": "9", "pages": "e040328"}, "abstract": "To assess the public's knowledge, attitudes and practices about the novel coronavirus in Sierra Leone to inform an evidence-based communication strategy around COVID-19.\r\n\r\nNationwide, cross-sectional Knowledge, Attitudes and Practices survey.\r\n\r\n56 randomly selected communities in all 14 districts in Sierra Leone.\r\n\r\n1253 adults aged 18 years and older of which 52% were men.\r\n\r\nWe calculated proportions of core indicators (awareness, knowledge, risk perception, practices). A composite variable for knowledge (based on seven variables) was created, and categorised into low (0-2 correct), medium (3-4) and high (5-7). Predictors of knowledge were analysed with multilevel ordinal regression models. Associations between information sources, knowledge and two practices (washing hands with soap and avoiding crowds) were analysed using multilevel logistic regression models.\r\n\r\nWe found that 75% of the respondents felt at moderate or great risk of contracting coronavirus. A majority (70%) of women did not know you can survive COVID-19, compared with 61% of men. 60% of men and 54% of women had already taken action to avoid infection with the coronavirus, mostly washing hands with soap and water (87%). Radio (73%) was the most used source for COVID-19 information, followed by social media (39%). Having a medium or high level of knowledge was associated with higher odds of washing hands with soap (medium knowledge: adjusted OR (AOR) 2.1, 95% CI 1.0 to 4.4; high knowledge: AOR 4.6, 95% CI 2.1 to 10.2) and avoiding crowds (medium knowledge: AOR 2.0, 95% CI 1.1 to 3.6; high knowledge: AOR 2.3, 95% CI 1.2 to 4.3).\r\n\r\nThis study shows that in the context of COVID-19 in Sierra Leone, there is a strong association between knowledge and practices. Because the knowledge gap differs between genders, regions, educational levels and age, it is important that messages are specifically targeted to these core audiences.", "doi": "10.1136/bmjopen-2020-040328", "pmid": "32948576", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-040328"}, {"db": "pmc", "key": "PMC7500298"}], "notes": [], "created": "2020-12-03T15:25:05.492Z", "modified": "2022-11-10T06:29:42.518Z"}, {"entity": "publication", "iuid": "5dc281be97ab40e09602086957f75065", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5dc281be97ab40e09602086957f75065.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5dc281be97ab40e09602086957f75065"}}, "title": "Randomized elimination and prolongation of ACE inhibitors and ARBs in coronavirus 2019 (REPLACE COVID) Trial Protocol.", "authors": [{"family": "Cohen", "given": "Jordana B", "initials": "JB"}, {"family": "Hanff", "given": "Thomas C", "initials": "TC"}, {"family": "Corrales-Medina", "given": "Vicente", "initials": "V"}, {"family": "William", "given": "Preethi", "initials": "P"}, {"family": "Renna", "given": "Nicolas", "initials": "N"}, {"family": "Rosado-Santander", "given": "Nelson R", "initials": "NR"}, {"family": "Rodriguez-Mori", "given": "Juan E", "initials": "JE"}, {"family": "Spaak", "given": "Jonas", "initials": "J"}, {"family": "Andrade-Villanueva", "given": "Jaime", "initials": "J"}, {"family": "Chang", "given": "Tara I", "initials": "TI"}, {"family": "Barbagelata", "given": "Alejandro", "initials": "A"}, {"family": "Alfonso", "given": "Carlos E", "initials": "CE"}, {"family": "Bernales-Salas", "given": "Eduardo", "initials": "E"}, {"family": "Coacalla", "given": "Johanna", "initials": "J"}, {"family": "Castro-Callirgos", "given": "Carlos Augusto", "initials": "CA"}, {"family": "Tupayachi-Venero", "given": "Karen E", "initials": "KE"}, {"family": "Medina", "given": "Carola", "initials": "C"}, {"family": "Valdivia", "given": "Renzo", "initials": "R"}, {"family": "Villavicencio", "given": "Mirko", "initials": "M"}, {"family": "Vasquez", "given": "Charles R", "initials": "CR"}, {"family": "Harhay", "given": "Michael O", "initials": "MO"}, {"family": "Chittams", "given": "Jesse", "initials": "J"}, {"family": "Sharkoski", "given": "Tiffany", "initials": "T"}, {"family": "Byrd", "given": "James Brian", "initials": "JB"}, {"family": "Edmonston", "given": "Daniel L", "initials": "DL"}, {"family": "Sweitzer", "given": "Nancy", "initials": "N"}, {"family": "Chirinos", "given": "Julio A", "initials": "JA"}], "type": "journal article", "published": "2020-09-16", "journal": {"title": "J Clin Hypertens (Greenwich)", "issn": "1751-7176", "volume": null, "issue": null, "issn-l": "1524-6175"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), is associated with high incidence of multiorgan dysfunction and death. Angiotensin-converting enzyme 2 (ACE2), which facilitates SARS-CoV-2 host cell entry, may be impacted by angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), two commonly used antihypertensive classes. In a multicenter, international randomized controlled trial that began enrollment on March 31, 2020, participants are randomized to continuation vs withdrawal of their long-term outpatient ACEI or ARB upon hospitalization with COVID-19. The primary outcome is a hierarchical global rank score incorporating time to death, duration of mechanical ventilation, duration of renal replacement or vasopressor therapy, and multiorgan dysfunction severity. Approval for the study has been obtained from the Institutional Review Board of each participating institution, and all participants will provide informed consent. A data safety monitoring board has been assembled to provide independent oversight of the project.", "doi": "10.1111/jch.14011", "pmid": "32937008", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-26T14:07:07.090Z", "modified": "2020-11-27T12:42:14.575Z"}, {"entity": "publication", "iuid": "1b3238e3b30b41ffb504a180899ff5d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b3238e3b30b41ffb504a180899ff5d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b3238e3b30b41ffb504a180899ff5d9"}}, "title": "Correction to: Psychometric Validation of the Bangla Fear of COVID-19 Scale: Confirmatory Factor Analysis and Rasch Analysis.", "authors": [{"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA"}], "type": "journal article", "published": "2020-09-16", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "volume": null, "issue": null, "pages": "1-3", "issn-l": null}, "abstract": null, "doi": "10.1007/s11469-020-00399-6", "pmid": "32958998", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "399"}, {"db": "pmc", "key": "PMC7493694"}], "notes": [], "created": "2020-12-03T09:28:53.598Z", "modified": "2020-12-03T09:28:53.611Z"}, {"entity": "publication", "iuid": "36ef7db8e3064cca91e3a0646b84fbb5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/36ef7db8e3064cca91e3a0646b84fbb5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/36ef7db8e3064cca91e3a0646b84fbb5"}}, "title": "Estimating the impact of mobility patterns on COVID-19 infection rates in 11 European countries.", "authors": [{"family": "Bryant", "given": "Patrick", "initials": "P"}, {"family": "Elofsson", "given": "Arne", "initials": "A"}], "type": "journal article", "published": "2020-09-15", "journal": {"title": "PeerJ", "issn": "2167-8359", "issn-l": "2167-8359", "volume": "8", "issue": null, "pages": "e9879"}, "abstract": "As governments across Europe have issued non-pharmaceutical interventions (NPIs) such as social distancing and school closing, the mobility patterns in these countries have changed. Most states have implemented similar NPIs at similar time points. However, it is likely different countries and populations respond differently to the NPIs and that these differences cause mobility patterns and thereby the epidemic development to change.\r\n\r\nWe build a Bayesian model that estimates the number of deaths on a given day dependent on changes in the basic reproductive number, R0, due to differences in mobility patterns. We utilise mobility data from Google mobility reports using five different categories: retail and recreation, grocery and pharmacy, transit stations, workplace and residential. The importance of each mobility category for predicting changes in R0 is estimated through the model.\r\n\r\nThe changes in mobility have a considerable overlap with the introduction of governmental NPIs, highlighting the importance of government action for population behavioural change. The shift in mobility in all categories shows high correlations with the death rates 1 month later. Reduction of movement within the grocery and pharmacy sector is estimated to account for most of the decrease in R0.\r\n\r\nOur model predicts 3-week epidemic forecasts, using real-time observations of changes in mobility patterns, which can provide governments with direct feedback on the effects of their NPIs. The model predicts the changes in a majority of the countries accurately but overestimates the impact of NPIs in Sweden and Denmark and underestimates them in France and Belgium. We also note that the exponential nature of all epidemiological models based on the basic reproductive number, R0 cause small errors to have extensive effects on the predicted outcome.", "doi": "10.7717/peerj.9879", "pmid": "32983643", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://github.com/patrickbryant1/COVID19.github.io/tree/master/simulations/mobility", "description": "Modelling code and data"}], "notes": [], "created": "2020-10-30T12:05:16.028Z", "modified": "2021-02-26T08:45:48.044Z"}, {"entity": "publication", "iuid": "b5b2d03702cc482b86707ae25d5fac83", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5b2d03702cc482b86707ae25d5fac83.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5b2d03702cc482b86707ae25d5fac83"}}, "title": "Cloth Masks May Prevent Transmission of COVID-19: An Evidence-Based, Risk-Based Approach.", "authors": [{"family": "Clase", "given": "Catherine M", "initials": "CM"}, {"family": "Fu", "given": "Edouard L", "initials": "EL"}, {"family": "Joseph", "given": "Meera", "initials": "M"}, {"family": "Beale", "given": "Rupert C L", "initials": "RCL"}, {"family": "Dolovich", "given": "Myrna B", "initials": "MB"}, {"family": "Jardine", "given": "Meg", "initials": "M"}, {"family": "Mann", "given": "Johannes F E", "initials": "JFE"}, {"family": "Pecoits-Filho", "given": "Roberto", "initials": "R"}, {"family": "Winkelmayer", "given": "Wolfgang C", "initials": "WC"}, {"family": "Carrero", "given": "Juan J", "initials": "JJ"}], "type": "editorial", "published": "2020-09-15", "journal": {"title": "Ann Intern Med", "issn": "1539-3704", "volume": "173", "issue": "6", "pages": "489-491", "issn-l": "0003-4819"}, "abstract": null, "doi": "10.7326/M20-2567", "pmid": "32441991", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7277485"}], "notes": [], "created": "2020-11-25T09:12:11.027Z", "modified": "2020-12-09T11:33:38.890Z"}, {"entity": "publication", "iuid": "142a4622975548cca4f4ddbb2bfbcc1c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/142a4622975548cca4f4ddbb2bfbcc1c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/142a4622975548cca4f4ddbb2bfbcc1c"}}, "title": "Spatio-Temporal Mutational Profile Appearances of Swedish SARS-CoV-2 during the Early Pandemic.", "authors": [{"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Hickman", "given": "Rachel A", "initials": "RA"}, {"family": "Li", "given": "Jinlin", "initials": "J"}, {"family": "Lu", "given": "Xi", "initials": "X"}, {"family": "Lindahl", "given": "Johanna F", "initials": "JF"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}], "type": "journal article", "published": "2020-09-14", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "12", "issue": "9", "pages": null}, "abstract": "During the COVID-19 pandemic, the virus evolved, and we therefore aimed to provide an insight into which genetic variants were enriched, and how they spread in Sweden.\r\n\r\nWe analyzed 348 Swedish SARS-CoV-2 sequences freely available from GISAID obtained from 7 February 2020 until 14 May 2020.\r\n\r\nWe identified 14 variant sites \u22655% frequency in the population. Among those sites, the D936Y substitution in the viral Spike protein was under positive selection. The variant sites can distinguish 11 mutational profiles in Sweden. Nine of the profiles appeared in Stockholm in March 2020. Mutational profiles 3 (B.1.1) and 6 (B.1), which contain the D936Y mutation, became the predominant profiles over time, spreading from Stockholm to other Swedish regions during April and the beginning of May. Furthermore, Bayesian phylogenetic analysis indicated that SARS-CoV-2 could have emerged in Sweden on 27 December 2019, and community transmission started on February 1st with an evolutionary rate of 1.5425 \u00d7 10 -3 substitutions per year.\r\n\r\nOur study provides novel knowledge on the spatio-temporal dynamics of Swedish SARS-CoV-2 variants during the early pandemic. Characterization of these viral variants can provide precious insights on viral pathogenesis and can be valuable for diagnostic and drug development approaches.", "doi": "10.3390/v12091026", "pmid": "32937868", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Drug discovery and repurposing of drugs": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "http://www.mdpi.com/1999-4915/12/9/1026/s1", "description": "Spatial temporal appearance of each variant and their mutation profile and clade information; Other supplementary materials."}], "notes": [], "created": "2020-10-28T09:08:27.508Z", "modified": "2021-06-13T14:21:08.152Z"}, {"entity": "publication", "iuid": "383eab77f1844350b33ce8258212261e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/383eab77f1844350b33ce8258212261e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/383eab77f1844350b33ce8258212261e"}}, "title": "Psychological Distress and Problem Gambling in Elite Athletes during COVID-19 Restrictions-A Web Survey in Top Leagues of Three Sports during the Pandemic.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "J\u00f6nsson", "given": "Caroline", "initials": "C"}, {"family": "Kentt\u00e4", "given": "G\u00f6ran", "initials": "G"}], "type": "journal article", "published": "2020-09-14", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "18", "pages": null}, "abstract": "COVID-19 and lockdown strategies may affect mental health and addictive behavior differently in the population, and elite athletes are among the professions clearly affected by the pandemic. This study in top elite athletes aimed to study current perceived psychological influence from COVID-19 and symptoms of depression, anxiety and changes in alcohol drinking, gambling behavior and problem gambling in the midst of the COVID-19 lockdown. This web survey included athletes in top leagues of soccer, ice hockey and handball in Sweden (N = 327, 62% men). A total of 66% and 51% were worried about the future of their sport or about their own future in sports, respectively. Feeling worse psychologically during the pandemic was common (72% of women, 40% of men, p < 0.001); depression criteria were endorsed by 19% of women and three percent of men (p < 0.001); anxiety criteria by 20% of women and five percent of men (p < 0.001). Reporting increased gambling during the pandemic was associated with gambling problem severity. Moderate-risk or problem gambling was seen in 10% of men and none of the women (p < 0.001). Depression and anxiety were associated with feeling worse during the COVID-19 pandemic and with concern over one's own sports future. In conclusion, COVID-19-related distress is common in elite athletes and associated with mental health symptoms. Gambling increase during the pandemic was rare, but related to gambling problems, which were common in male athletes. The calls for increased focus on COVID-19-related concerns in athletes and on problem gambling in male athletes.", "doi": "10.3390/ijerph17186693", "pmid": "32937978", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "ijerph17186693"}, {"db": "pmc", "key": "PMC7559357"}], "notes": [], "created": "2020-12-03T15:31:15.752Z", "modified": "2022-11-10T06:31:52.371Z"}, {"entity": "publication", "iuid": "6186d266f41a4cd995e5edb8ec12c8fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6186d266f41a4cd995e5edb8ec12c8fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6186d266f41a4cd995e5edb8ec12c8fd"}}, "title": "Pandemic programming: How COVID-19 affects software developers and how their organizations can help.", "authors": [{"family": "Ralph", "given": "Paul", "initials": "P"}, {"family": "Baltes", "given": "Sebastian", "initials": "S"}, {"family": "Adisaputri", "given": "Gianisa", "initials": "G"}, {"family": "Torkar", "given": "Richard", "initials": "R"}, {"family": "Kovalenko", "given": "Vladimir", "initials": "V"}, {"family": "Kalinowski", "given": "Marcos", "initials": "M"}, {"family": "Novielli", "given": "Nicole", "initials": "N"}, {"family": "Yoo", "given": "Shin", "initials": "S"}, {"family": "Devroey", "given": "Xavier", "initials": "X"}, {"family": "Tan", "given": "Xin", "initials": "X"}, {"family": "Zhou", "given": "Minghui", "initials": "M"}, {"family": "Turhan", "given": "Burak", "initials": "B"}, {"family": "Hoda", "given": "Rashina", "initials": "R"}, {"family": "Hata", "given": "Hideaki", "initials": "H"}, {"family": "Robles", "given": "Gregorio", "initials": "G"}, {"family": "Milani Fard", "given": "Amin", "initials": "A"}, {"family": "Alkadhi", "given": "Rana", "initials": "R"}], "type": "journal article", "published": "2020-09-14", "journal": {"title": "Empir Softw Eng", "issn": "1573-7616", "volume": null, "issue": null, "pages": "1-35", "issn-l": null}, "abstract": "As a novel coronavirus swept the world in early 2020, thousands of software developers began working from home. Many did so on short notice, under difficult and stressful conditions.\n\nThis study investigates the effects of the pandemic on developers' wellbeing and productivity.\n\nA questionnaire survey was created mainly from existing, validated scales and translated into 12 languages. The data was analyzed using non-parametric inferential statistics and structural equation modeling.\n\nThe questionnaire received 2225 usable responses from 53 countries. Factor analysis supported the validity of the scales and the structural model achieved a good fit (CFI = 0.961, RMSEA = 0.051, SRMR = 0.067). Confirmatory results include: (1) the pandemic has had a negative effect on developers' wellbeing and productivity; (2) productivity and wellbeing are closely related; (3) disaster preparedness, fear related to the pandemic and home office ergonomics all affect wellbeing or productivity. Exploratory analysis suggests that: (1) women, parents and people with disabilities may be disproportionately affected; (2) different people need different kinds of support.\n\nTo improve employee productivity, software companies should focus on maximizing employee wellbeing and improving the ergonomics of employees' home offices. Women, parents and disabled persons may require extra support.", "doi": "10.1007/s10664-020-09875-y", "pmid": "32952438", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "9875"}, {"db": "pmc", "key": "PMC7489196"}], "notes": [], "created": "2020-12-03T09:33:26.473Z", "modified": "2020-12-03T15:24:20.243Z"}, {"entity": "publication", "iuid": "0b5aef6454014621b5298e639210e0c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b5aef6454014621b5298e639210e0c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b5aef6454014621b5298e639210e0c9"}}, "title": "Shedding of infectious SARS-CoV-2 from airways in hospitalized COVID-19 patients in relation to serum antibody responses", "authors": [{"family": "Glans", "given": "Hedvig", "initials": "H"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Olausson", "given": "Mikaela", "initials": "M"}, {"family": "Falck-Jones", "given": "Sara", "initials": "S"}, {"family": "Varnaite", "given": "Renata", "initials": "R"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Lind Karlberg", "given": "Maria", "initials": "M"}, {"family": "Broddesson", "given": "Sandra", "initials": "S"}, {"family": "Falck-Jones", "given": "Ryan", "initials": "R"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Farnert", "given": "Anna", "initials": "A"}, {"family": "Smed Sorensen", "given": "Anna", "initials": "A"}, {"family": "Klingstrom", "given": "Jonas", "initials": "J"}, {"family": "Brave", "given": "Andreas", "initials": "A"}], "type": "posted-content", "published": "2020-09-13", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "issn-l": null, "volume": "21", "issue": "1", "pages": "494"}, "abstract": "To understand the risk of transmission of SARS-CoV-2 in hospitalized COVID-19 patients we simultaneously assessed the presence of SARS-CoV-2 RNA, live infectious virus in the airways, and virus-specific IgG and neutralizing antibodies in sera in 36 hospitalized COVID-19 patients. SARS-CoV-2 could be cultured from four patients, all with low or undetectable antibody response. Our data suggests that the level of SARS-CoV-2 antibodies may correlate to risk for shedding live SARS-CoV-2 virus in hospitalized COVID-19 patients.", "doi": "10.1186/s12879-021-06202-8", "pmid": "34044758", "labels": {"Funder: VR": null, "Category: Genomics & transcriptomics": null, "Category: Health": null, "Type: Journal article": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [], "notes": [], "created": "2020-10-29T12:35:34.869Z", "modified": "2021-11-18T08:50:56.330Z"}, {"entity": "publication", "iuid": "732dbf77b4de4598938e1ad6efc93392", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/732dbf77b4de4598938e1ad6efc93392.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/732dbf77b4de4598938e1ad6efc93392"}}, "title": "Guidance for the Management of Patients with Vascular Disease or Cardiovascular Risk Factors and COVID-19: Position Paper from VAS-European Independent Foundation in Angiology/Vascular Medicine.", "authors": [{"family": "Gerotziafas", "given": "Grigoris T", "initials": "GT"}, {"family": "Catalano", "given": "Mariella", "initials": "M"}, {"family": "Colgan", "given": "Mary-Paula", "initials": "MP"}, {"family": "Pecsvarady", "given": "Zsolt", "initials": "Z"}, {"family": "Wautrecht", "given": "Jean Claude", "initials": "JC"}, {"family": "Fazeli", "given": "Bahare", "initials": "B"}, {"family": "Olinic", "given": "Dan-Mircea", "initials": "DM"}, {"family": "Farkas", "given": "Katalin", "initials": "K"}, {"family": "Elalamy", "given": "Ismail", "initials": "I"}, {"family": "Falanga", "given": "Anna", "initials": "A"}, {"family": "Fareed", "given": "Jawed", "initials": "J"}, {"family": "Papageorgiou", "given": "Chryssa", "initials": "C"}, {"family": "Arellano", "given": "Rosella S", "initials": "RS"}, {"family": "Agathagelou", "given": "Petros", "initials": "P"}, {"family": "Antic", "given": "Darco", "initials": "D"}, {"family": "Auad", "given": "Luciana", "initials": "L"}, {"family": "Banfic", "given": "Ljiljana", "initials": "L"}, {"family": "Bartolomew", "given": "John R", "initials": "JR"}, {"family": "Benczur", "given": "Bela", "initials": "B"}, {"family": "Bernardo", "given": "Melissa B", "initials": "MB"}, {"family": "Boccardo", "given": "Francesco", "initials": "F"}, {"family": "Cifkova", "given": "Renate", "initials": "R"}, {"family": "Cosmi", "given": "Benilde", "initials": "B"}, {"family": "De Marchi", "given": "Sergio", "initials": "S"}, {"family": "Dimakakos", "given": "Evangelos", "initials": "E"}, {"family": "Dimopoulos", "given": "Meletios A", "initials": "MA"}, {"family": "Dimitrov", "given": "Gabriel", "initials": "G"}, {"family": "Durand-Zaleski", "given": "Isabelle", "initials": "I"}, {"family": "Edmonds", "given": "Michael", "initials": "M"}, {"family": "El Nazar", "given": "Essam Abo", "initials": "EA"}, {"family": "Erer", "given": "Dilek", "initials": "D"}, {"family": "Esponda", "given": "Omar L", "initials": "OL"}, {"family": "Gresele", "given": "Paolo", "initials": "P"}, {"family": "Gschwandtner", "given": "Michael", "initials": "M"}, {"family": "Gu", "given": "Yongquan", "initials": "Y"}, {"family": "Heinzmann", "given": "M\u00f3nica", "initials": "M"}, {"family": "Hamburg", "given": "Naomi M", "initials": "NM"}, {"family": "Hamad\u00e9", "given": "Amer", "initials": "A"}, {"family": "Jatoi", "given": "Noor-Ahmed", "initials": "NA"}, {"family": "Karahan", "given": "Oguz", "initials": "O"}, {"family": "Karetova", "given": "Debora", "initials": "D"}, {"family": "Karplus", "given": "Thomas", "initials": "T"}, {"family": "Klein-Weigel", "given": "Peter", "initials": "P"}, {"family": "Kolossvary", "given": "Endre", "initials": "E"}, {"family": "Kozak", "given": "Matija", "initials": "M"}, {"family": "Lefkou", "given": "Eleftheria", "initials": "E"}, {"family": "Lessiani", "given": "Gianfranco", "initials": "G"}, {"family": "Liew", "given": "Aaron", "initials": "A"}, {"family": "Marcoccia", "given": "Antonella", "initials": "A"}, {"family": "Marshang", "given": "Peter", "initials": "P"}, {"family": "Marakomichelakis", "given": "George", "initials": "G"}, {"family": "Matuska", "given": "Jiri", "initials": "J"}, {"family": "Moraglia", "given": "Luc", "initials": "L"}, {"family": "Pillon", "given": "Sergio", "initials": "S"}, {"family": "Poredos", "given": "Pavel", "initials": "P"}, {"family": "Prior", "given": "Manlio", "initials": "M"}, {"family": "Salvador", "given": "David Raymund K", "initials": "DRK"}, {"family": "Schlager", "given": "Oliver", "initials": "O"}, {"family": "Schernthaner", "given": "Gerit", "initials": "G"}, {"family": "Sieron", "given": "Alexander", "initials": "A"}, {"family": "Spaak", "given": "Jonas", "initials": "J"}, {"family": "Spyropoulos", "given": "Alex", "initials": "A"}, {"family": "Sprynger", "given": "Muriel", "initials": "M"}, {"family": "Suput", "given": "Dusan", "initials": "D"}, {"family": "Stanek", "given": "Agata", "initials": "A"}, {"family": "Stvrtinova", "given": "Viera", "initials": "V"}, {"family": "Szuba", "given": "Andrzej", "initials": "A"}, {"family": "Tafur", "given": "Alfonso", "initials": "A"}, {"family": "Vandreden", "given": "Patrick", "initials": "P"}, {"family": "Vardas", "given": "Panagiotis E", "initials": "PE"}, {"family": "Vasic", "given": "Dragan", "initials": "D"}, {"family": "Vikkula", "given": "Miikka", "initials": "M"}, {"family": "Wennberg", "given": "Paul", "initials": "P"}, {"family": "Zhai", "given": "Zhenguo", "initials": "Z"}, {"family": "Scientific Reviewer Committee", "given": "", "initials": ""}], "type": "journal article", "published": "2020-09-13", "journal": {"title": "Thromb Haemost", "issn": "2567-689X", "volume": null, "issue": null, "issn-l": "0340-6245"}, "abstract": "COVID-19 is also manifested with hypercoagulability, pulmonary intravascular coagulation, microangiopathy, and venous thromboembolism (VTE) or arterial thrombosis. Predisposing risk factors to severe COVID-19 are male sex, underlying cardiovascular disease, or cardiovascular risk factors including noncontrolled diabetes mellitus or arterial hypertension, obesity, and advanced age. The VAS-European Independent Foundation in Angiology/Vascular Medicine draws attention to patients with vascular disease (VD) and presents an integral strategy for the management of patients with VD or cardiovascular risk factors (VD-CVR) and COVID-19. VAS recommends (1) a COVID-19-oriented primary health care network for patients with VD-CVR for identification of patients with VD-CVR in the community and patients' education for disease symptoms, use of eHealth technology, adherence to the antithrombotic and vascular regulating treatments, and (2) close medical follow-up for efficacious control of VD progression and prompt application of physical and social distancing measures in case of new epidemic waves. For patients with VD-CVR who receive home treatment for COVID-19, VAS recommends assessment for (1) disease worsening risk and prioritized hospitalization of those at high risk and (2) VTE risk assessment and thromboprophylaxis with rivaroxaban, betrixaban, or low-molecular-weight heparin (LMWH) for those at high risk. For hospitalized patients with VD-CVR and COVID-19, VAS recommends (1) routine thromboprophylaxis with weight-adjusted intermediate doses of LMWH (unless contraindication); (2) LMWH as the drug of choice over unfractionated heparin or direct oral anticoagulants for the treatment of VTE or hypercoagulability; (3) careful evaluation of the risk for disease worsening and prompt application of targeted antiviral or convalescence treatments; (4) monitoring of D-dimer for optimization of the antithrombotic treatment; and (5) evaluation of the risk of VTE before hospital discharge using the IMPROVE-D-dimer score and prolonged post-discharge thromboprophylaxis with rivaroxaban, betrixaban, or LMWH.", "doi": "10.1055/s-0040-1715798", "pmid": "32920811", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-03T15:37:40.375Z", "modified": "2020-12-03T15:38:41.229Z"}, {"entity": "publication", "iuid": "87e3177a4f144265bc03fab88fd9a870", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87e3177a4f144265bc03fab88fd9a870.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87e3177a4f144265bc03fab88fd9a870"}}, "title": "Zoonotic Diseases: Etiology, Impact, and Control.", "authors": [{"family": "Rahman", "given": "Md Tanvir", "initials": "MT"}, {"family": "Sobur", "given": "Md Abdus", "initials": "MA"}, {"family": "Islam", "given": "Md Saiful", "initials": "MS"}, {"family": "Ievy", "given": "Samina", "initials": "S"}, {"family": "Hossain", "given": "Md Jannat", "initials": "MJ"}, {"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME"}, {"family": "Rahman", "given": "Amm Taufiquer", "initials": "AT"}, {"family": "Ashour", "given": "Hossam M", "initials": "HM"}], "type": "journal article", "published": "2020-09-12", "journal": {"title": "Microorganisms", "issn": "2076-2607", "volume": "8", "issue": "9", "pages": null, "issn-l": "2076-2607"}, "abstract": "Most humans are in contact with animals in a way or another. A zoonotic disease is a disease or infection that can be transmitted naturally from vertebrate animals to humans or from humans to vertebrate animals. More than 60% of human pathogens are zoonotic in origin. This includes a wide variety of bacteria, viruses, fungi, protozoa, parasites, and other pathogens. Factors such as climate change, urbanization, animal migration and trade, travel and tourism, vector biology, anthropogenic factors, and natural factors have greatly influenced the emergence, re-emergence, distribution, and patterns of zoonoses. As time goes on, there are more emerging and re-emerging zoonotic diseases. In this review, we reviewed the etiology of major zoonotic diseases, their impact on human health, and control measures for better management. We also highlighted COVID-19, a newly emerging zoonotic disease of likely bat origin that has affected millions of humans along with devastating global consequences. The implementation of One Health measures is highly recommended for the effective prevention and control of possible zoonosis.", "doi": "10.3390/microorganisms8091405", "pmid": "32932606", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "microorganisms8091405"}, {"db": "pmc", "key": "PMC7563794"}], "notes": [], "created": "2020-11-22T09:35:07.748Z", "modified": "2020-12-03T15:33:04.091Z"}, {"entity": "publication", "iuid": "cea2db86142e40b78905aca930630de3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cea2db86142e40b78905aca930630de3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cea2db86142e40b78905aca930630de3"}}, "title": "Response to the Novel Corona Virus (COVID-19) Pandemic Across Africa: Successes, Challenges, and Implications for the Future.", "authors": [{"family": "Ogunleye", "given": "Olayinka O", "initials": "OO"}, {"family": "Basu", "given": "Debashis", "initials": "D"}, {"family": "Mueller", "given": "Debjani", "initials": "D"}, {"family": "Sneddon", "given": "Jacqueline", "initials": "J"}, {"family": "Seaton", "given": "R Andrew", "initials": "RA"}, {"family": "Yinka-Ogunleye", "given": "Adesola F", "initials": "AF"}, {"family": "Wamboga", "given": "Joshua", "initials": "J"}, {"family": "Miljkovi\u0107", "given": "Nenad", "initials": "N"}, {"family": "Mwita", "given": "Julius C", "initials": "JC"}, {"family": "Rwegerera", "given": "Godfrey Mutashambara", "initials": "GM"}, {"family": "Massele", "given": "Amos", "initials": "A"}, {"family": "Patrick", "given": "Okwen", "initials": "O"}, {"family": "Niba", "given": "Loveline Lum", "initials": "LL"}, {"family": "Nsaikila", "given": "Melaine", "initials": "M"}, {"family": "Rashed", "given": "Wafaa M", "initials": "WM"}, {"family": "Hussein", "given": "Mohamed Ali", "initials": "MA"}, {"family": "Hegazy", "given": "Rehab", "initials": "R"}, {"family": "Amu", "given": "Adefolarin A", "initials": "AA"}, {"family": "Boahen-Boaten", "given": "Baffour Boaten", "initials": "BB"}, {"family": "Matsebula", "given": "Zinhle", "initials": "Z"}, {"family": "Gwebu", "given": "Prudence", "initials": "P"}, {"family": "Chirigo", "given": "Bongani", "initials": "B"}, {"family": "Mkhabela", "given": "Nongabisa", "initials": "N"}, {"family": "Dlamini", "given": "Tenelisiwe", "initials": "T"}, {"family": "Sithole", "given": "Siphiwe", "initials": "S"}, {"family": "Malaza", "given": "Sandile", "initials": "S"}, {"family": "Dlamini", "given": "Sikhumbuzo", "initials": "S"}, {"family": "Afriyie", "given": "Daniel", "initials": "D"}, {"family": "Asare", "given": "George Awuku", "initials": "GA"}, {"family": "Amponsah", "given": "Seth Kwabena", "initials": "SK"}, {"family": "Sefah", "given": "Israel", "initials": "I"}, {"family": "Oluka", "given": "Margaret", "initials": "M"}, {"family": "Guantai", "given": "Anastasia N", "initials": "AN"}, {"family": "Opanga", "given": "Sylvia A", "initials": "SA"}, {"family": "Sarele", "given": "Tebello Violet", "initials": "TV"}, {"family": "Mafisa", "given": "Refeletse Keabetsoe", "initials": "RK"}, {"family": "Chikowe", "given": "Ibrahim", "initials": "I"}, {"family": "Khuluza", "given": "Felix", "initials": "F"}, {"family": "Kibuule", "given": "Dan", "initials": "D"}, {"family": "Kalemeera", "given": "Francis", "initials": "F"}, {"family": "Mubita", "given": "Mwangana", "initials": "M"}, {"family": "Fadare", "given": "Joseph", "initials": "J"}, {"family": "Sibomana", "given": "Laurien", "initials": "L"}, {"family": "Ramokgopa", "given": "Gwendoline Malegwale", "initials": "GM"}, {"family": "Whyte", "given": "Carmen", "initials": "C"}, {"family": "Maimela", "given": "Tshegofatso", "initials": "T"}, {"family": "Hugo", "given": "Johannes", "initials": "J"}, {"family": "Meyer", "given": "Johanna C", "initials": "JC"}, {"family": "Schellack", "given": "Natalie", "initials": "N"}, {"family": "Rampamba", "given": "Enos M", "initials": "EM"}, {"family": "Visser", "given": "Adel", "initials": "A"}, {"family": "Alfadl", "given": "Abubakr", "initials": "A"}, {"family": "Malik", "given": "Elfatih M", "initials": "EM"}, {"family": "Malande", "given": "Oliver Ombeva", "initials": "OO"}, {"family": "Kalungia", "given": "Aubrey C", "initials": "AC"}, {"family": "Mwila", "given": "Chiluba", "initials": "C"}, {"family": "Zaranyika", "given": "Trust", "initials": "T"}, {"family": "Chaibva", "given": "Blessmore Vimbai", "initials": "BV"}, {"family": "Olaru", "given": "Ioana D", "initials": "ID"}, {"family": "Masuka", "given": "Nyasha", "initials": "N"}, {"family": "Wale", "given": "Janney", "initials": "J"}, {"family": "Hwenda", "given": "Lenias", "initials": "L"}, {"family": "Kamoga", "given": "Regina", "initials": "R"}, {"family": "Hill", "given": "Ruaraidh", "initials": "R"}, {"family": "Barbui", "given": "Corrado", "initials": "C"}, {"family": "Bochenek", "given": "Tomasz", "initials": "T"}, {"family": "Kurdi", "given": "Amanj", "initials": "A"}, {"family": "Campbell", "given": "Stephen", "initials": "S"}, {"family": "Martin", "given": "Antony P", "initials": "AP"}, {"family": "Phuong", "given": "Thuy Nguyen Thi", "initials": "TNT"}, {"family": "Thanh", "given": "Binh Nguyen", "initials": "BN"}, {"family": "Godman", "given": "Brian", "initials": "B"}], "type": "journal article", "published": "2020-09-11", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "11", "issue": null, "pages": "1205", "issn-l": "1663-9812"}, "abstract": "The COVID-19 pandemic has already claimed considerable lives. There are major concerns in Africa due to existing high prevalence rates for both infectious and non-infectious diseases and limited resources in terms of personnel, beds and equipment. Alongside this, concerns that lockdown and other measures will have on prevention and management of other infectious diseases and non-communicable diseases (NCDs). NCDs are an increasing issue with rising morbidity and mortality rates. The World Health Organization (WHO) warns that a lack of nets and treatment could result in up to 18 million additional cases of malaria and up to 30,000 additional deaths in sub-Saharan Africa.\n\nDocument current prevalence and mortality rates from COVID-19 alongside economic and other measures to reduce its spread and impact across Africa. In addition, suggested ways forward among all key stakeholder groups.\n\nContextualise the findings from a wide range of publications including internet-based publications coupled with input from senior-level personnel.\n\nPrevalence and mortality rates are currently lower in Africa than among several Western countries and the USA. This could be due to a number of factors including early instigation of lockdown and border closures, the younger age of the population, lack of robust reporting systems and as yet unidentified genetic and other factors. Innovation is accelerating to address concerns with available equipment. There are ongoing steps to address the level of misinformation and its consequences including fines. There are also ongoing initiatives across Africa to start addressing the unintended consequences of COVID-19 activities including lockdown measures and their impact on NCDs including the likely rise in mental health disorders, exacerbated by increasing stigma associated with COVID-19. Strategies include extending prescription lengths, telemedicine and encouraging vaccination. However, these need to be accelerated to prevent increased morbidity and mortality.\n\nThere are multiple activities across Africa to reduce the spread of COVID-19 and address misinformation, which can have catastrophic consequences, assisted by the WHO and others, which appear to be working in a number of countries. Research is ongoing to clarify the unintended consequences given ongoing concerns to guide future activities. Countries are learning from each other.", "doi": "10.3389/fphar.2020.01205", "pmid": "33071775", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7533592"}], "notes": [], "created": "2020-11-26T12:24:30.995Z", "modified": "2020-11-26T12:24:31.017Z"}, {"entity": "publication", "iuid": "23b3b226c1804746af8f9473c4c7563f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23b3b226c1804746af8f9473c4c7563f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23b3b226c1804746af8f9473c4c7563f"}}, "title": "Piecewise quadratic growth during the 2019 novel coronavirus epidemic.", "authors": [{"family": "Brandenburg", "given": "Axel", "initials": "A"}], "type": "journal article", "published": "2020-09-11", "journal": {"title": "Infect Dis Model", "issn": "2468-0427", "volume": "5", "issue": null, "pages": "681-690", "issn-l": null}, "abstract": "The temporal growth in the number of deaths in the COVID-19 epidemic is subexponential. Here we show that a piecewise quadratic law provides an excellent fit during the thirty days after the first three fatalities on January 20 and later since the end of March 2020. There is also a brief intermediate period of exponential growth. During the second quadratic growth phase, the characteristic time of the growth is about eight times shorter than in the beginning, which can be understood as the occurrence of separate hotspots. Quadratic behavior can be motivated by peripheral growth when further spreading occurs only on the outskirts of an infected region. We also study numerical solutions of a simple epidemic model, where the spatial extend of the system is taken into account. To model the delayed onset outside China together with the early one in China within a single model with minimal assumptions, we adopt an initial condition of several hotspots, of which one reaches saturation much earlier than the others. At each site, quadratic growth commences when the local number of infections has reached a certain saturation level. The total number of deaths does then indeed follow a piecewise quadratic behavior.", "doi": "10.1016/j.idm.2020.08.014", "pmid": "32954094", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2468-0427(20)30044-0"}, {"db": "pmc", "key": "PMC7485523"}], "notes": [], "created": "2020-12-03T09:33:11.690Z", "modified": "2020-12-03T09:33:11.704Z"}, {"entity": "publication", "iuid": "1ec555708e424f25a0d57786d6bd022e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ec555708e424f25a0d57786d6bd022e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ec555708e424f25a0d57786d6bd022e"}}, "title": "Development, clinical translation, and utility of a COVID-19 antibody test with qualitative and quantitative readouts.", "authors": [{"family": "Bortz", "given": "Robert H", "initials": "RH"}, {"family": "Florez", "given": "Catalina", "initials": "C"}, {"family": "Laudermilch", "given": "Ethan", "initials": "E"}, {"family": "Wirchnianski", "given": "Ariel S", "initials": "AS"}, {"family": "Lasso", "given": "Gorka", "initials": "G"}, {"family": "Malonis", "given": "Ryan J", "initials": "RJ"}, {"family": "Georgiev", "given": "George I", "initials": "GI"}, {"family": "Vergnolle", "given": "Olivia", "initials": "O"}, {"family": "Herrera", "given": "Natalia G", "initials": "NG"}, {"family": "Morano", "given": "Nicholas C", "initials": "NC"}, {"family": "Campbell", "given": "Sean T", "initials": "ST"}, {"family": "Orner", "given": "Erika P", "initials": "EP"}, {"family": "Mengotto", "given": "Amanda", "initials": "A"}, {"family": "Dieterle", "given": "M Eugenia", "initials": "ME"}, {"family": "Fels", "given": "Jens Maximilian", "initials": "JM"}, {"family": "Haslwanter", "given": "Denise", "initials": "D"}, {"family": "Jangra", "given": "Rohit", "initials": "R"}, {"family": "Celikgil", "given": "Alev", "initials": "A"}, {"family": "Kimmel", "given": "Duncan", "initials": "D"}, {"family": "Lee", "given": "James H", "initials": "JH"}, {"family": "Mariano", "given": "Margarette", "initials": "M"}, {"family": "Nakouzi", "given": "Antonio", "initials": "A"}, {"family": "Quiroz", "given": "Jose", "initials": "J"}, {"family": "Rivera", "given": "Johanna", "initials": "J"}, {"family": "Szymczak", "given": "Wendy A", "initials": "WA"}, {"family": "Tong", "given": "Karen", "initials": "K"}, {"family": "Barnhill", "given": "Jason", "initials": "J"}, {"family": "Forsell", "given": "Mattias Ne", "initials": "MN"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Stein", "given": "Daniel T", "initials": "DT"}, {"family": "Pirofski", "given": "Liise-Anne", "initials": "L"}, {"family": "Goldstein", "given": "Doctor Y", "initials": "DY"}, {"family": "Garforth", "given": "Scott J", "initials": "SJ"}, {"family": "Almo", "given": "Steven C", "initials": "SC"}, {"family": "Daily", "given": "Johanna P", "initials": "JP"}, {"family": "Prystowsky", "given": "Michael B", "initials": "MB"}, {"family": "Faix", "given": "James D", "initials": "JD"}, {"family": "Fox", "given": "Amy S", "initials": "AS"}, {"family": "Weiss", "given": "Louis M", "initials": "LM"}, {"family": "Lai", "given": "Jonathan R", "initials": "JR"}, {"family": "Chandran", "given": "Kartik", "initials": "K"}], "type": "preprint", "published": "2020-09-11", "journal": {"title": "mSphere", "issn": "2379-5042", "issn-l": null, "volume": "6", "issue": "2", "pages": null}, "abstract": "The COVID-19 global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to place an immense burden on societies and healthcare systems. A key component of COVID-19 control efforts is serologic testing to determine the community prevalence of SARS-CoV-2 exposure and quantify individual immune responses to prior infection or vaccination. Here, we describe a laboratory-developed antibody test that uses readily available research-grade reagents to detect SARS-CoV-2 exposure in patient blood samples with high sensitivity and specificity. We further show that this test affords the estimation of viral spike-specific IgG titers from a single sample measurement, thereby providing a simple and scalable method to measure the strength of an individual's immune response. The accuracy, adaptability, and cost-effectiveness of this test makes it an excellent option for clinical deployment in the ongoing COVID-19 pandemic.", "doi": "10.1128/mSphere.00224-21", "pmid": null, "labels": {"Category: Biochemistry": null, "Category: Health": null, "Category: Serology": null, "Category: Proteins": null, "Type: Journal article": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-11-04T15:35:31.660Z", "modified": "2021-04-23T04:34:32.198Z"}, {"entity": "publication", "iuid": "44c735f6e3364a05a857311d3471133b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44c735f6e3364a05a857311d3471133b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44c735f6e3364a05a857311d3471133b"}}, "title": "Can intravenous oxytocin infusion counteract hyperinflammation in COVID-19 infected patients?", "authors": [{"family": "Buemann", "given": "Benjamin", "initials": "B"}, {"family": "Marazziti", "given": "Donatella", "initials": "D"}, {"family": "Uvn\u00e4s-Moberg", "given": "Kerstin", "initials": "K"}], "type": "journal article", "published": "2020-09-11", "journal": {"title": "World J Biol Psychiatry", "issn": "1814-1412", "volume": null, "issue": null, "pages": "1-12", "issn-l": null}, "abstract": "Based on its well-documented anti-inflammatory and restorative properties we propose trials with the natural hormone oxytocin for treatment of hospitalised Covid-19 patients.\n\nWe searched for, retrieved, and commented on specific literature regarding multiple functions of oxytocin with a special focus on its modulation of inflammatory, immune, and restorative functions.\n\nAvailable data gathered in animals and humans support the anti-inflammatory properties of oxytocin. The multiple anti-inflammatory effects of oxytocin have been demonstrated in vitro and in vivo in various animal models and also in humans in response to intravenous infusion of oxytocin. Furthermore, oxytocin has been documented to activate several types of protective and restorative mechanisms and to exert positive effects on the immune system.\n\nIn addition, to being anti-inflammatory, it may be hypothesised, that oxytocin may be less suppressive on adaptive immune systems, as compared with glucocorticoids. Finally, by its restorative effects coupled with its anti-stress and healing properties, oxytocin may shorten the recovery period of the Covid-19 patients.", "doi": "10.1080/15622975.2020.1814408", "pmid": "32914674", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-03T15:50:41.427Z", "modified": "2020-12-03T15:50:41.437Z"}, {"entity": "publication", "iuid": "c0dccb4b5d464861a2edc7e0621fa33f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c0dccb4b5d464861a2edc7e0621fa33f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c0dccb4b5d464861a2edc7e0621fa33f"}}, "title": "Covid-19 as cultural trauma.", "authors": [{"family": "Demertzis", "given": "Nicolas", "initials": "N"}, {"family": "Eyerman", "given": "Ron", "initials": "R"}], "type": "journal article", "published": "2020-09-10", "journal": {"title": "Am J Cult Sociol", "issn": "2049-7113", "volume": null, "issue": null, "pages": "1-23", "issn-l": null}, "abstract": "This paper has two aims. The first is to introduce the concept of compressed cultural trauma, and the second is to apply the theory of cultural trauma in two case studies of the current covid-19 pandemic, Greece and Sweden. Our central question is whether the pandemic will evolve into a cultural trauma in these two countries. We believe the pandemic presents a challenge to cultural trauma theory, which the idea of compressed trauma is meant to address. We conclude that, while the ongoing covid-19 pandemic has had traumatic consequences in Sweden and Greece, it has not evolved into cultural trauma in either country.", "doi": "10.1057/s41290-020-00112-z", "pmid": "32929388", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "112"}, {"db": "pmc", "key": "PMC7481543"}], "notes": [], "created": "2020-12-03T15:35:12.134Z", "modified": "2020-12-03T15:35:12.159Z"}, {"entity": "publication", "iuid": "2edf22a701b24f3a9e15b94b30781900", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2edf22a701b24f3a9e15b94b30781900.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2edf22a701b24f3a9e15b94b30781900"}}, "title": "COVID-19 Pandemic Control: Lessons Learned From Hai Phong City, Vietnam.", "authors": [{"family": "Tran", "given": "Thanh Chi", "initials": "TC"}, {"family": "Ngo", "given": "The Anh", "initials": "TA"}, {"family": "Nguyen", "given": "Thanh Duc", "initials": "TD"}, {"family": "Olson", "given": "Linus", "initials": "L"}, {"family": "Larsson", "given": "Mattias", "initials": "M"}], "type": "journal article", "published": "2020-09-10", "journal": {"title": "Asia Pac J Public Health", "issn": "1941-2479", "volume": null, "issue": null, "pages": "1010539520956424", "issn-l": null}, "abstract": "The COVID-19 (coronavirus disease-2019) pandemic has affected almost all countries in the world. When the first cases were reported from Hubei, China, in late December 2019, the Vietnamese authorities acknowledged the potential risk of an epidemic having had the experience of severe acute respiratory syndrome (SARS) and the Avian flu. When it was clear that there was human-to-human transmission in the epidemic in Wuhan that started in January 2020, the Vietnamese government, health care system, and civil society were rapidly mobilized. How has a country with a population of about 100 million and a long porous border to China managed to prevent a larger outbreak? This case history is about how Hai Phong city implemented the initial COVID-19 response. Hai Phong reacted quickly after the COVID-19 outbreak in China by, quarantining people coming from pandemic areas, and carrying out contact tracing and extensive testing, closing schools and universities and implementing two weeks of social distancing measures. There are no detected positive cases until May 18, 2020 in Hai Phong.", "doi": "10.1177/1010539520956424", "pmid": "32909472", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-03T15:51:38.418Z", "modified": "2020-12-03T15:51:38.442Z"}, {"entity": "publication", "iuid": "56b0b53e67ce45b68fad60337e0aa7a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56b0b53e67ce45b68fad60337e0aa7a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56b0b53e67ce45b68fad60337e0aa7a6"}}, "title": "Is COVID-19 spreading and curing silently: an observation of three family clusters in Bangladesh.", "authors": [{"family": "Hoq", "given": "Mohammad Injamul", "initials": "MI"}, {"family": "Hossain", "given": "Md Mohotasin", "initials": "MM"}, {"family": "Roshni", "given": "Umme Sayma", "initials": "US"}, {"family": "Sayeed", "given": "Mohammed Aktar", "initials": "MA"}, {"family": "Tohura", "given": "Saraban", "initials": "S"}, {"family": "Jakaria", "given": "Md", "initials": "M"}], "type": "case reports", "published": "2020-09-09", "journal": {"title": "J Basic Clin Physiol Pharmacol", "issn": "2191-0286", "issn-l": null, "volume": "31", "issue": "6", "pages": null}, "abstract": "Objectives The number of coronavirus disease (COVID-19) cases is increasing in Bangladesh. Many people have suffered from symptoms like COVID-19 during this pandemic, and some people have cured without taking any treatment or taking minor pharmacological and non-pharmacological treatments. However, they might be spreading their infections among their family members and perhaps in the community. It is unsure that individuals with COVID-19-like symptoms are positive with COVID-19, but our concern is, during this pandemic, any types of symptoms such as flu-like symptoms should have been taken seriously. This study was observed in the cases from three families with COVID-19 like symptoms. Case presentation This observational study was done between May 20 and Jun 2, 2020, in Bangladesh. The members of the inspected families shared COVID-19 like symptoms that were lasted for 3-10 days. Conclusions COVID-19 might be spread and cured silently in Bangladesh, which recommends that awareness is needed throughout the country to prevent the spreading of the disease.", "doi": "10.1515/jbcpp-2020-0224", "pmid": "32903208", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "/j/jbcpp.ahead-of-print/jbcpp-2020-0224/jbcpp-2020-0224.xml"}], "notes": [], "created": "2020-12-03T16:16:25.822Z", "modified": "2022-11-10T06:39:33.321Z"}, {"entity": "publication", "iuid": "eb78f8ab3f6c40afbc9c4dbb77e7d827", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb78f8ab3f6c40afbc9c4dbb77e7d827.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb78f8ab3f6c40afbc9c4dbb77e7d827"}}, "title": "What do people hospitalised with covid-19 think about the care they received?", "authors": [{"family": "Wu", "given": "Meng-San", "initials": "MS"}, {"family": "Hayat", "given": "Fatima", "initials": "F"}, {"family": "Ratcliffe", "given": "Libuse", "initials": "L"}, {"family": "Beadsworth", "given": "Mike B J", "initials": "MBJ"}, {"family": "Defres", "given": "Sylviane", "initials": "S"}, {"family": "Wingfield", "given": "Tom", "initials": "T"}], "type": "letter", "published": "2020-09-08", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "370", "issue": null, "pages": "m3496", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m3496", "pmid": "32900791", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-06T07:15:59.881Z", "modified": "2020-12-06T07:16:27.079Z"}, {"entity": "publication", "iuid": "6f64f5b4044d4dad891fbcc8cae95651", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f64f5b4044d4dad891fbcc8cae95651.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f64f5b4044d4dad891fbcc8cae95651"}}, "title": "The influence of sex and gender domains on COVID-19 cases and mortality.", "authors": [{"family": "Tadiri", "given": "Christina P", "initials": "CP"}, {"family": "Gisinger", "given": "Teresa", "initials": "T"}, {"family": "Kautzy-Willer", "given": "Alexandra", "initials": "A"}, {"family": "Kublickiene", "given": "Karolina", "initials": "K"}, {"family": "Herrero", "given": "Maria Trinidad", "initials": "MT"}, {"family": "Raparelli", "given": "Valeria", "initials": "V"}, {"family": "Pilote", "given": "Louise", "initials": "L"}, {"family": "Norris", "given": "Colleen M", "initials": "CM"}, {"family": "GOING-FWD Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2020-09-08", "journal": {"title": "CMAJ", "issn": "1488-2329", "volume": "192", "issue": "36", "pages": "E1041-E1045", "issn-l": null}, "abstract": null, "doi": "10.1503/cmaj.200971", "pmid": "32900766", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "192/36/E1041"}, {"db": "pmc", "key": "PMC7504881"}], "notes": [], "created": "2020-12-06T07:20:20.362Z", "modified": "2020-12-06T07:20:20.386Z"}, {"entity": "publication", "iuid": "3a3b8e0c4e7c43e9aac18620677bfd64", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a3b8e0c4e7c43e9aac18620677bfd64.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a3b8e0c4e7c43e9aac18620677bfd64"}}, "title": "Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates.", "authors": [{"family": "Damas", "given": "Joana", "initials": "J", "orcid": "0000-0003-4857-2510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d86c6ce3efc8438cb022b0a6116ec808.json"}}, {"family": "Hughes", "given": "Graham M", "initials": "GM", "orcid": "0000-0003-3088-345X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7cca5ad139542a09d41aacc87cef194.json"}}, {"family": "Keough", "given": "Kathleen C", "initials": "KC", "orcid": "0000-0002-7481-0511", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31418e90941f44ed9f7baac2fc2b0ca5.json"}}, {"family": "Painter", "given": "Corrie A", "initials": "CA", "orcid": "0000-0001-6174-1548", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b93e610d9a7448d2b1b04013fee689e3.json"}}, {"family": "Persky", "given": "Nicole S", "initials": "NS", "orcid": "0000-0002-9948-2761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b64350d9c0a406396b36eabd6c372c4.json"}}, {"family": "Corbo", "given": "Marco", "initials": "M", "orcid": "0000-0002-4566-2724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67850769221d40e3bc798c393b4f559f.json"}}, {"family": "Hiller", "given": "Michael", "initials": "M", "orcid": "0000-0003-3024-1449", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74b8c53343314dde971b5f1d9ba7adc4.json"}}, {"family": "Koepfli", "given": "Klaus-Peter", "initials": "KP", "orcid": "0000-0001-7281-0676", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb8ddd52615d4685adb7985d9a79f361.json"}}, {"family": "Pfenning", "given": "Andreas R", "initials": "AR", "orcid": "0000-0002-3447-9801", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35a8a125b8ba47378aa05db0f82c774b.json"}}, {"family": "Zhao", "given": "Huabin", "initials": "H", "orcid": "0000-0002-7848-6392", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ff10d2b3b3c4465ae9edf8d8e270fd9.json"}}, {"family": "Genereux", "given": "Diane P", "initials": "DP", "orcid": "0000-0001-5770-0989", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59c3f0cfa3bf46f58e5ee2d98a935a2c.json"}}, {"family": "Swofford", "given": "Ross", "initials": "R", "orcid": "0000-0003-3676-8479", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e4973c0096a496fb46269c0d1e1e8d1.json"}}, {"family": "Pollard", "given": "Katherine S", "initials": "KS", "orcid": "0000-0002-9870-6196", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5281b158f9334e39a18cfb618cd1f6fc.json"}}, {"family": "Ryder", "given": "Oliver A", "initials": "OA", "orcid": "0000-0003-2427-763X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e2fd53a69c14ea0a555a974df5186f1.json"}}, {"family": "Nweeia", "given": "Martin T", "initials": "MT", "orcid": "0000-0001-7079-4123", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12f0f63b2b3545f8a6f76bdf9c9c10b3.json"}}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K", "orcid": "0000-0001-8338-0253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/159b64d0fe104764b779588736155088.json"}}, {"family": "Teeling", "given": "Emma C", "initials": "EC", "orcid": "0000-0002-3309-1346", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a9c530af6e24c07931ae16eed8fd5ed.json"}}, {"family": "Karlsson", "given": "Elinor K", "initials": "EK", "orcid": "0000-0002-4343-3776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff1d0b875064bc9b8c54d5af01ec13c.json"}}, {"family": "Lewin", "given": "Harris A", "initials": "HA", "orcid": "0000-0002-1043-7287", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8feb3ed5d3a14dea95ed77742bd1e569.json"}}], "type": "comparative study", "published": "2020-09-08", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "117", "issue": "36", "pages": "22311-22322", "issn-l": "0027-8424"}, "abstract": "The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19. The main receptor of SARS-CoV-2, angiotensin I converting enzyme 2 (ACE2), is now undergoing extensive scrutiny to understand the routes of transmission and sensitivity in different species. Here, we utilized a unique dataset of ACE2 sequences from 410 vertebrate species, including 252 mammals, to study the conservation of ACE2 and its potential to be used as a receptor by SARS-CoV-2. We designed a five-category binding score based on the conservation properties of 25 amino acids important for the binding between ACE2 and the SARS-CoV-2 spike protein. Only mammals fell into the medium to very high categories and only catarrhine primates into the very high category, suggesting that they are at high risk for SARS-CoV-2 infection. We employed a protein structural analysis to qualitatively assess whether amino acid changes at variable residues would be likely to disrupt ACE2/SARS-CoV-2 spike protein binding and found the number of predicted unfavorable changes significantly correlated with the binding score. Extending this analysis to human population data, we found only rare (frequency <0.001) variants in 10/25 binding sites. In addition, we found significant signals of selection and accelerated evolution in the ACE2 coding sequence across all mammals, and specific to the bat lineage. Our results, if confirmed by additional experimental data, may lead to the identification of intermediate host species for SARS-CoV-2, guide the selection of animal models of COVID-19, and assist the conservation of animals both in native habitats and in human care.", "doi": "10.1073/pnas.2010146117", "pmid": "32826334", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7486773"}, {"db": "pii", "key": "2010146117"}], "notes": [], "created": "2020-12-07T11:52:39.925Z", "modified": "2023-06-19T14:38:30.044Z"}, {"entity": "publication", "iuid": "3e9b231b9d9a4b1d837d4b4ebf1662db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3e9b231b9d9a4b1d837d4b4ebf1662db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3e9b231b9d9a4b1d837d4b4ebf1662db"}}, "title": "Acute necrotizing encephalopathy with SARS-CoV-2 RNA confirmed in cerebrospinal fluid", "authors": [{"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "F\u00e4llmar", "given": "David", "initials": "D"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Jackmann", "given": "Sven", "initials": "S"}, {"family": "Sk\u00f6ld", "given": "Mattias K", "initials": "MK"}, {"family": "Kadir", "given": "Mohamed", "initials": "M"}, {"family": "Frick", "given": "Jens", "initials": "J"}, {"family": "Lindeberg", "given": "Jonas", "initials": "J"}, {"family": "Olivero-Reinius", "given": "Henrik", "initials": "H"}, {"family": "Ryttlefors", "given": "Mats", "initials": "M"}, {"family": "Cunningham", "given": "Janet L", "initials": "JL"}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Grabowska", "given": "Anna", "initials": "A"}, {"family": "Bondeson", "given": "K\u00e5re", "initials": "K"}, {"family": "Bergquist", "given": "Jonas", "initials": "J"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Rostami", "given": "Elham", "initials": "E"}], "type": "journal-article", "published": "2020-09-08", "journal": {"title": "Neurology", "issn": "1526-632X", "volume": "95", "issue": "10", "pages": "445-449", "issn-l": "0028-3878"}, "abstract": "Here, we report a case of COVID-19\u2013related acute necrotizing encephalopathy where SARS-CoV-2 RNA was found in CSF 19 days after symptom onset after testing negative twice. Although monocytes and protein levels in CSF were only marginally increased, and our patient never experienced a hyperinflammatory state, her neurologic function deteriorated into coma. MRI of the brain showed pathologic signal symmetrically in central thalami, subinsular regions, medial temporal lobes, and brain stem. Extremely high concentrations of the neuronal injury markers neurofilament light and tau, as well as an astrocytic activation marker, glial fibrillary acidic protein, were measured in CSF. Neuronal rescue proteins and other pathways were elevated in the in-depth proteomics analysis. The patient received IV immunoglobulins and plasma exchange. Her neurologic status improved, and she was extubated 4 weeks after symptom onset. This case report highlights the neurotropism of SARS-CoV-2 in selected patients and emphasizes the importance of repeated lumbar punctures and CSF analyses in patients with suspected COVID-19 and neurologic symptoms.", "doi": "10.1212/wnl.0000000000010250", "pmid": "32586897", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.5061/dryad.xwdbrv1bb", "description": "Proteomic data"}], "notes": [], "created": "2020-11-04T07:45:09.549Z", "modified": "2021-02-26T08:45:48.083Z"}, {"entity": "publication", "iuid": "ac5dc94540534786a6d4b0d8241c1d1c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac5dc94540534786a6d4b0d8241c1d1c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac5dc94540534786a6d4b0d8241c1d1c"}}, "title": "Use of biologicals in allergic and type-2 inflammatory diseases during the current COVID-19 pandemic: Position paper of \u00c4rzteverband Deutscher Allergologen (AeDA) A, Deutsche Gesellschaft f\u00fcr Allergologie und Klinische Immunologie (DGAKI)B, Gesellschaft f\u00fcr P\u00e4diatrische Allergologie und Umweltmedizin (GPA)C, \u00d6sterreichische Gesellschaft f\u00fcr Allergologie und Immunologie (\u00d6GAI)D, Luxemburgische Gesellschaft f\u00fcr Allergologie und Immunologie (LGAI)E, \u00d6sterreichische Gesellschaft f\u00fcr Pneumologie (\u00d6GP)F in co-operation with the German, Austrian, and Swiss ARIA groupsG, and the European Academy of Allergy and Clinical Immunology (EAACI)H.", "authors": [{"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Worm", "given": "Margitta", "initials": "M"}, {"family": "Eiwegger", "given": "Thomas", "initials": "T"}, {"family": "Hagemann", "given": "Jan", "initials": "J"}, {"family": "Ollert", "given": "Markus", "initials": "M"}, {"family": "Untersmayr", "given": "Eva", "initials": "E"}, {"family": "Hoffmann-Sommergruber", "given": "Karin", "initials": "K"}, {"family": "Vultaggio", "given": "Alessandra", "initials": "A"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Bavbek", "given": "Sevim", "initials": "S"}, {"family": "Bossios", "given": "Apostolos", "initials": "A"}, {"family": "Casper", "given": "Ingrid", "initials": "I"}, {"family": "Chan", "given": "Susan", "initials": "S"}, {"family": "Chatzipetrou", "given": "Alexia", "initials": "A"}, {"family": "Vogelberg", "given": "Christian", "initials": "C"}, {"family": "Firinu", "given": "Davide", "initials": "D"}, {"family": "Kauppi", "given": "Paula", "initials": "P"}, {"family": "Kolios", "given": "Antonios", "initials": "A"}, {"family": "Kothari", "given": "Akash", "initials": "A"}, {"family": "Matucci", "given": "Andrea", "initials": "A"}, {"family": "Palomares", "given": "Oscar", "initials": "O"}, {"family": "Sz\u00e9pfalusi", "given": "Zsolt", "initials": "Z"}, {"family": "Pohl", "given": "Wolfgang", "initials": "W"}, {"family": "H\u00f6tzenecker", "given": "Wolfram", "initials": "W"}, {"family": "Rosenkranz", "given": "Alexander R", "initials": "AR"}, {"family": "Bergmann", "given": "Karl-Christian", "initials": "KC"}, {"family": "Bieber", "given": "Thomas", "initials": "T"}, {"family": "Buhl", "given": "Roland", "initials": "R"}, {"family": "Buters", "given": "Jeroen", "initials": "J"}, {"family": "Darsow", "given": "Ulf", "initials": "U"}, {"family": "Keil", "given": "Thomas", "initials": "T"}, {"family": "Kleine-Tebbe", "given": "J\u00f6rg", "initials": "J"}, {"family": "Lau", "given": "Susanne", "initials": "S"}, {"family": "Maurer", "given": "Marcus", "initials": "M"}, {"family": "Merk", "given": "Hans", "initials": "H"}, {"family": "M\u00f6sges", "given": "Ralph", "initials": "R"}, {"family": "Saloga", "given": "Joachim", "initials": "J"}, {"family": "Staubach", "given": "Petra", "initials": "P"}, {"family": "Jappe", "given": "Uta", "initials": "U"}, {"family": "Rabe", "given": "Klaus F", "initials": "KF"}, {"family": "Rabe", "given": "Uta", "initials": "U"}, {"family": "Vogelmeier", "given": "Claus", "initials": "C"}, {"family": "Biedermann", "given": "Tilo", "initials": "T"}, {"family": "Jung", "given": "Kirsten", "initials": "K"}, {"family": "Schlenter", "given": "Wolfgang", "initials": "W"}, {"family": "Ring", "given": "Johannes", "initials": "J"}, {"family": "Chaker", "given": "Adam", "initials": "A"}, {"family": "Wehrmann", "given": "Wolfgang", "initials": "W"}, {"family": "Becker", "given": "Sven", "initials": "S"}, {"family": "Freudelsperger", "given": "Laura", "initials": "L"}, {"family": "M\u00fclleneisen", "given": "Norbert", "initials": "N"}, {"family": "Nemat", "given": "Katja", "initials": "K"}, {"family": "Czech", "given": "Wolfgang", "initials": "W"}, {"family": "Wrede", "given": "Holger", "initials": "H"}, {"family": "Brehler", "given": "Randolf", "initials": "R"}, {"family": "Fuchs", "given": "Thomas", "initials": "T"}, {"family": "Tomazic", "given": "Peter-Valentin", "initials": "PV"}, {"family": "Aberer", "given": "Werner", "initials": "W"}, {"family": "Fink-Wagner", "given": "Antje-Henriette", "initials": "AH"}, {"family": "Horak", "given": "Fritz", "initials": "F"}, {"family": "W\u00f6hrl", "given": "Stefan", "initials": "S"}, {"family": "Niederberger-Leppin", "given": "Verena", "initials": "V"}, {"family": "Pali-Sch\u00f6ll", "given": "Isabella", "initials": "I"}, {"family": "Roller-Wirnsberger", "given": "Regina", "initials": "R"}, {"family": "Spranger", "given": "Otto", "initials": "O"}, {"family": "Valenta", "given": "Rudolf", "initials": "R"}, {"family": "Akdis", "given": "M\u00fcbecell", "initials": "M"}, {"family": "Matricardi", "given": "Paolo M", "initials": "PM"}, {"family": "Spertini", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Khaltaev", "given": "Nicolai", "initials": "N"}, {"family": "Michel", "given": "Jean-Pierre", "initials": "JP"}, {"family": "Nicod", "given": "Larent", "initials": "L"}, {"family": "Schmid-Grendelmeier", "given": "Peter", "initials": "P"}, {"family": "Idzko", "given": "Marco", "initials": "M"}, {"family": "Hamelmann", "given": "Eckard", "initials": "E"}, {"family": "Jakob", "given": "Thilo", "initials": "T"}, {"family": "Werfel", "given": "Thomas", "initials": "T"}, {"family": "Wagenmann", "given": "Martin", "initials": "M"}, {"family": "Taube", "given": "Christian", "initials": "C"}, {"family": "Jensen-Jarolim", "given": "Erika", "initials": "E"}, {"family": "Korn", "given": "Stephanie", "initials": "S"}, {"family": "Hentges", "given": "Francois", "initials": "F"}, {"family": "Schwarze", "given": "J\u00fcrgen", "initials": "J"}, {"family": "O Mahony", "given": "Liam", "initials": "L"}, {"family": "Knol", "given": "Edward F", "initials": "EF"}, {"family": "Del Giacco", "given": "Stefano", "initials": "S"}, {"family": "Chivato P\u00e9rez", "given": "Tom\u00e1s", "initials": "T"}, {"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Bedbrook", "given": "Anna", "initials": "A"}, {"family": "Zuberbier", "given": "Torsten", "initials": "T"}, {"family": "Akdis", "given": "Cezmi", "initials": "C"}, {"family": "Jutel", "given": "Marek", "initials": "M"}], "type": "journal article", "published": "2020-09-07", "journal": {"title": "Allergol Select", "issn": "2512-8957", "volume": "4", "issue": null, "pages": "53-68", "issn-l": null}, "abstract": "Since the beginning of the COVID-19 pandemic, the treatment of patients with allergic and atopy-associated diseases has faced major challenges. Recommendations for \"social distancing\" and the fear of patients becoming infected during a visit to a medical facility have led to a drastic decrease in personal doctor-patient contacts. This affects both acute care and treatment of the chronically ill. The immune response after SARS-CoV-2 infection is so far only insufficiently understood and could be altered in a favorable or unfavorable way by therapy with monoclonal antibodies. There is currently no evidence for an increased risk of a severe COVID-19 course in allergic patients. Many patients are under ongoing therapy with biologicals that inhibit type 2 immune responses via various mechanisms. There is uncertainty about possible immunological interactions and potential risks of these biologicals in the case of an infection with SARS-CoV-2.\n\nA selective literature search was carried out in PubMed, Livivo, and the internet to cover the past 10 years (May 2010 - April 2020). Additionally, the current German-language publications were analyzed. Based on these data, the present position paper provides recommendations for the biological treatment of patients with allergic and atopy-associated diseases during the COVID-19 pandemic.\n\nIn order to maintain in-office consultation services, a safe treatment environment must be created that is adapted to the pandemic situation. To date, there is a lack of reliable study data on the care for patients with complex respiratory, atopic, and allergic diseases in times of an imminent infection risk from SARS-CoV-2. Type-2-dominant immune reactions, as they are frequently seen in allergic patients, could influence various phases of COVID-19, e.g., by slowing down the immune reactions. Theoretically, this could have an unfavorable effect in the early phase of a SARS-Cov-2 infection, but also a positive effect during a cytokine storm in the later phase of severe courses. However, since there is currently no evidence for this, all data from patients treated with a biological directed against type 2 immune reactions who develop COVID-19 should be collected in registries, and their disease courses documented in order to be able to provide experience-based instructions in the future.\n\nThe use of biologicals for the treatment of bronchial asthma, atopic dermatitis, chronic rhinosinusitis with nasal polyps, and spontaneous urticaria should be continued as usual in patients without suspected infection or proven SARS-CoV-2 infection. If available, it is recommended to prefer a formulation for self-application and to offer telemedical monitoring. Treatment should aim at the best possible control of difficult-to-control allergic and atopic diseases using adequate rescue and add-on therapy and should avoid the need for systemic glucocorticosteroids. If SARS-CoV-2 infection is proven or reasonably suspected, the therapy should be determined by weighing the benefits and risks individually for the patient in question, and the patient should be involved in the decision-making. It should be kept in mind that the potential effects of biologicals on the immune response in COVID-19 are currently not known. Telemedical offers are particularly desirable for the acute consultation needs of suitable patients.", "doi": "10.5414/ALX02166E", "pmid": "32915172", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7480069"}], "notes": [], "created": "2020-12-03T15:49:30.607Z", "modified": "2020-12-03T15:49:30.629Z"}, {"entity": "publication", "iuid": "38380a4ee3434dedb9da6814ea406069", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38380a4ee3434dedb9da6814ea406069.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38380a4ee3434dedb9da6814ea406069"}}, "title": "Characteristics and outcomes of patients with COVID-19 admitted to ICU in a tertiary hospital in Stockholm, Sweden.", "authors": [{"family": "Larsson", "given": "Emma", "initials": "E"}, {"family": "Brattstr\u00f6m", "given": "Olof", "initials": "O"}, {"family": "Agvald-\u00d6hman", "given": "Christina", "initials": "C"}, {"family": "Grip", "given": "Jonathan", "initials": "J"}, {"family": "Campoccia Jalde", "given": "Francesca", "initials": "F"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}, {"family": "Oldner", "given": "Anders", "initials": "A"}, {"family": "Konrad", "given": "David", "initials": "D"}, {"family": "Persson", "given": "Bj\u00f6rn P", "initials": "BP"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}, {"family": "Karolinska Intensive Care COVID-19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-09-06", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": "65", "issue": "1", "pages": "76-81"}, "abstract": "Information on characteristics and outcomes of intensive care unit (ICU) patients with COVID-19 remains limited. We examined characteristics, clinical course and early outcomes of patients with COVID-19 admitted to ICU.\r\n\r\nWe included all 260 patients with COVID-19 admitted to nine ICUs at the Karolinska University Hospital (Stockholm, Sweden) between 9 March and 20 April 2020. Primary outcome was in-hospital mortality among patients with definite outcomes (discharged from ICU or death), as of 30 April 2020 (study end point). Secondary outcomes included ICU length of stay, the proportion of patients receiving mechanical ventilation and renal replacement therapy, and hospital discharge destination.\r\n\r\nOf 260 ICU patients with COVID-19, 208 (80.0%) were men, the median age was 59 (IQR 51-65) years, 154 (59.2%) had at least one comorbidity, and the median duration of symptoms preceding ICU admission was 11 (IQR 8-14) days. Sixty-two (23.8%) patients remained in ICU at study end point. Among the 198 patients with definite outcomes, ICU length of stay was 12 (IQR, 6-18) days, 163 (82.3%) received mechanical ventilation, 28 (14.1%) received renal replacement therapy, 60 (30.3%) died, 62 (31.3%) were discharged home, 47 (23.7%) were discharged to ward, and 29 (14.6%) were discharged to another health care facility. On multivariable logistic regression analysis, older age and admission from the emergency department was associated with higher mortality.\r\n\r\nThis study presents detailed data on clinical characteristics and early outcomes of consecutive patients with COVID-19 admitted to ICU in a large tertiary hospital in Sweden.", "doi": "10.1111/aas.13694", "pmid": "32892337", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-10-30T11:51:51.497Z", "modified": "2021-02-26T08:45:48.054Z"}, {"entity": "publication", "iuid": "0844d9bb4cf3455ca7975029df6d3bc0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0844d9bb4cf3455ca7975029df6d3bc0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0844d9bb4cf3455ca7975029df6d3bc0"}}, "title": "A Parsimonious Description and Cross-Country Analysis of COVID-19 Epidemic Curves.", "authors": [{"family": "Rypdal", "given": "Kristoffer", "initials": "K"}, {"family": "Rypdal", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2020-09-06", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "18", "pages": null}, "abstract": "In a given country, the cumulative death toll of the first wave of the COVID-19 epidemic follows a sigmoid curve as a function of time. In most cases, the curve is well described by the Gompertz function, which is characterized by two essential parameters, the initial growth rate and the decay rate as the first epidemic wave subsides. These parameters are determined by socioeconomic factors and the countermeasures to halt the epidemic. The Gompertz model implies that the total death toll depends exponentially, and hence very sensitively, on the ratio between these rates. The remarkably different epidemic curves for the first epidemic wave in Sweden and Norway and many other countries are classified and discussed in this framework, and their usefulness for the planning of mitigation strategies is discussed.", "doi": "10.3390/ijerph17186487", "pmid": "32899971", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "ijerph17186487"}, {"db": "pmc", "key": "PMC7559235"}], "notes": [], "created": "2020-12-06T07:16:46.279Z", "modified": "2022-11-10T06:40:21.982Z"}, {"entity": "publication", "iuid": "ed49959fb39d452fadbb4ffa061eb01e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed49959fb39d452fadbb4ffa061eb01e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed49959fb39d452fadbb4ffa061eb01e"}}, "title": "Virions and respiratory droplets in air: Diffusion, drift, and contact with the epithelium.", "authors": [{"family": "Zhdanov", "given": "Vladimir P", "initials": "VP"}, {"family": "Kasemo", "given": "Bengt", "initials": "B"}], "type": "journal article", "published": "2020-09-05", "journal": {"title": "Biosystems", "issn": "1872-8324", "volume": "198", "issue": null, "pages": "104241", "issn-l": null}, "abstract": "Some infections, including e.g. influenza and currently active COVID 19, may be transmitted via air during sneezing, coughing, and talking. This pathway occurs via diffusion and gravity-induced drift of single virions and respiratory droplets consisting primarily of water, including small fraction of nonvolatile matter, and containing virions. These processes are accompanied by water evaporation resulting in reduction of the droplet size. The manifold of information concerning these steps is presented in textbooks and articles not related to virology and the focus is there frequently on biologically irrelevant conditions and/or droplet sizes. In this brief review, we systematically describe the behavior of virions and virion-carrying droplets in air with emphasis on various regimes of diffusion, drift, and evaporation, and estimate the rates of all these steps under virologically relevant conditions. In addition, we discuss the kinetic aspects of the first steps of infection after attachment of virions or virion-carrying droplets to the epithelium, i.e., virion diffusion in the mucus and periciliary layers, penetration into the cells, and the early stage of replication. The presentation is oriented to virologists who are interested in the corresponding physics and to physicists who are interested in application of the physics to virology.", "doi": "10.1016/j.biosystems.2020.104241", "pmid": "32896576", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0303-2647(20)30129-5"}], "notes": [], "created": "2020-11-30T08:36:32.889Z", "modified": "2020-11-30T08:36:32.913Z"}, {"entity": "publication", "iuid": "4955f61547fa4675b79c608a93485b66", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4955f61547fa4675b79c608a93485b66.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4955f61547fa4675b79c608a93485b66"}}, "title": "Sarcoma European and Latin American Network (SELNET) Recommendations on Prioritization in Sarcoma Care During the COVID-19 Pandemic.", "authors": [{"family": "Martin-Broto", "given": "Javier", "initials": "J"}, {"family": "Hindi", "given": "Nadia", "initials": "N"}, {"family": "Aguiar", "given": "Samuel", "initials": "S"}, {"family": "Badilla-Gonz\u00e1lez", "given": "Ronald", "initials": "R"}, {"family": "Castro-Oliden", "given": "Victor", "initials": "V"}, {"family": "Chac\u00f3n", "given": "Matias", "initials": "M"}, {"family": "Correa-Generoso", "given": "Raquel", "initials": "R"}, {"family": "de \u00c1lava", "given": "Enrique", "initials": "E"}, {"family": "Donati", "given": "Davide Mar\u00eda", "initials": "DM"}, {"family": "Eriksson", "given": "Mikael", "initials": "M"}, {"family": "Falla-Jimenez", "given": "Martin", "initials": "M"}, {"family": "German", "given": "Gisela", "initials": "G"}, {"family": "Gobo Silva", "given": "Maria Leticia", "initials": "ML"}, {"family": "Gouin", "given": "Francois", "initials": "F"}, {"family": "Gronchi", "given": "Alessandro", "initials": "A"}, {"family": "Haro-Varas", "given": "Juan Carlos", "initials": "JC"}, {"family": "Jim\u00e9nez-Brenes", "given": "Natalia", "initials": "N"}, {"family": "Kasper", "given": "Bernd", "initials": "B"}, {"family": "Lopes de Mello", "given": "Celso Abdon", "initials": "CA"}, {"family": "Maki", "given": "Robert", "initials": "R"}, {"family": "Mart\u00ednez-Delgado", "given": "Paula", "initials": "P"}, {"family": "Mart\u00ednez-Said", "given": "Hector", "initials": "H"}, {"family": "Martinez-Tlahuel", "given": "Jorge Luis", "initials": "JL"}, {"family": "Morales-P\u00e9rez", "given": "Jose Manuel", "initials": "JM"}, {"family": "Mu\u00f1oz-Casares", "given": "Francisco Cristobal", "initials": "FC"}, {"family": "Nakagawa", "given": "Suely A", "initials": "SA"}, {"family": "Ortiz-Cruz", "given": "Eduardo Jose", "initials": "EJ"}, {"family": "Palmerini", "given": "Emanuela", "initials": "E"}, {"family": "Patel", "given": "Shreyaskumar", "initials": "S"}, {"family": "Moura", "given": "David S", "initials": "DS"}, {"family": "Stacchiotti", "given": "Silvia", "initials": "S"}, {"family": "Sunyach", "given": "Marie Pierre", "initials": "MP"}, {"family": "Valverde", "given": "Claudia M", "initials": "CM"}, {"family": "Waisberg", "given": "Federico", "initials": "F"}, {"family": "Blay", "given": "Jean-Yves", "initials": "JY"}], "type": "journal article", "published": "2020-09-05", "journal": {"title": "Oncologist", "issn": "1549-490X", "volume": null, "issue": null, "issn-l": null}, "abstract": "The COVID-19 outbreak has resulted in collision between patients infected with SARS-CoV-2 and those with cancer on different fronts. Patients with cancer have been impacted by deferral, modification, and even cessation of therapy. Adaptive measures to minimize hospital exposure, following the precautionary principle, have been proposed for cancer care during COVID-19 era. We present here a consensus on prioritizing recommendations across the continuum of sarcoma patient care.\n\nA total of 125 recommendations were proposed in soft-tissue, bone, and visceral sarcoma care. Recommendations were assigned as higher or lower priority if they cannot or can be postponed at least 2-3 months, respectively. The consensus level for each recommendation was classified as \"strongly recommended\" (SR) if more than 90% of experts agreed, \"recommended\" (R) if 75%-90% of experts agreed and \"no consensus\" (NC) if fewer than 75% agreed. Sarcoma experts from 11 countries within the Sarcoma European-Latin American Network (SELNET) consortium participated, including countries in the Americas and Europe. The European Society for Medical Oncology-Magnitude of clinical benefit scale was applied to systemic-treatment recommendations to support prioritization.\n\nThere were 80 SRs, 35 Rs, and 10 NCs among the 125 recommendations issued and completed by 31 multidisciplinary sarcoma experts. The consensus was higher among the 75 higher-priority recommendations (85%, 12%, and 3% for SR, R, and NC, respectively) than in the 50 lower-priority recommendations (32%, 52%, and 16% for SR, R, and NC, respectively).\n\nThe consensus on 115 of 125 recommendations indicates a high-level of convergence among experts. The SELNET consensus provides a tool for sarcoma multidisciplinary treatment committees during the COVID-19 outbreak.\n\nThe Sarcoma European-Latin American Network (SELNET) consensus on sarcoma prioritization care during the COVID-19 era issued 125 pragmatical recommendations distributed as higher or lower priority to protect critical decisions on sarcoma care during the COVID-19 pandemic. A multidisciplinary team from 11 countries reached consensus on 115 recommendations. The consensus was lower among lower-priority recommendations, which shows reticence to postpone actions even in indolent tumors. The European Society for Medical Oncology-Magnitude of Clinical Benefit scale was applied as support for prioritizing systemic treatment. Consensus on 115 of 125 recommendations indicates a high level of convergence among experts. The SELNET consensus provides a practice tool for guidance in the decisions of sarcoma multidisciplinary treatment committees during the COVID-19 outbreak.", "doi": "10.1634/theoncologist.2020-0516", "pmid": "32888360", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7543334"}], "notes": [], "created": "2020-12-06T07:27:04.756Z", "modified": "2020-12-06T07:27:04.766Z"}, {"entity": "publication", "iuid": "f35daacf9246431abd1b5eac85d3010c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f35daacf9246431abd1b5eac85d3010c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f35daacf9246431abd1b5eac85d3010c"}}, "title": "Treatment with angiotensin II in COVID-19 patients may not be beneficial.", "authors": [{"family": "Rysz", "given": "Susanne", "initials": "S"}, {"family": "Jalde", "given": "Francesca Campoccia", "initials": "FC"}, {"family": "Oldner", "given": "Anders", "initials": "A"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Lundberg", "given": "Johan", "initials": "J"}, {"family": "Fagerlund", "given": "Malin Jonsson", "initials": "MJ"}], "type": "letter", "published": "2020-09-04", "journal": {"title": "Crit Care", "issn": "1466-609X", "volume": "24", "issue": "1", "pages": "546", "issn-l": "1364-8535"}, "abstract": null, "doi": "10.1186/s13054-020-03233-6", "pmid": "32887650", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-020-03233-6"}, {"db": "pmc", "key": "PMC7472408"}], "notes": [], "created": "2020-12-06T07:27:42.373Z", "modified": "2020-12-06T07:27:42.386Z"}, {"entity": "publication", "iuid": "3aa6e6a8aff044aebc36dc62bc8c6b52", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3aa6e6a8aff044aebc36dc62bc8c6b52.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3aa6e6a8aff044aebc36dc62bc8c6b52"}}, "title": "Complicated COVID-19 in pregnancy: a case report with severe liver and coagulation dysfunction promptly improved by delivery.", "authors": [{"family": "Ronnje", "given": "Louise", "initials": "L"}, {"family": "L\u00e4nsberg", "given": "John-Kalle", "initials": "JK"}, {"family": "Vikhareva", "given": "Olga", "initials": "O"}, {"family": "Hansson", "given": "Stefan R", "initials": "SR"}, {"family": "Herbst", "given": "Andreas", "initials": "A"}, {"family": "Zaigham", "given": "Mehreen", "initials": "M"}], "type": "journal article", "published": "2020-09-04", "journal": {"title": "BMC Pregnancy Childbirth", "issn": "1471-2393", "volume": "20", "issue": "1", "pages": "511", "issn-l": null}, "abstract": "It has been proposed that pregnant women and their fetuses may be particularly at risk for poor outcomes due to the coronavirus (COVID-19) pandemic. From the few case series that are available in the literature, women with high risk pregnancies have been associated with higher morbidity. It has been suggested that pregnancy induced immune responses and cardio-vascular changes can exaggerate the course of the COVID-19 infection.\n\nA 26-year old Somalian woman (G2P1) presented with a nine-day history of shortness of breath, dry cough, myalgia, nausea, abdominal pain and fever. A nasopharyngeal swab returned positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Her condition rapidly worsened leading to severe liver and coagulation impairment. An emergency Caesarean section was performed at gestational week 32 + 6 after which the patient made a rapid recovery. Severe COVID-19 promptly improved by the termination of the pregnancy or atypical HELLP (Hemolysis, Elevated Liver Enzymes and Low Platelet Count) exacerbated by concomitant COVID-19 infection could not be ruled out. There was no evidence of vertical transmission.\n\nThis case adds to the growing body of evidence which raises concerns about the possible negative maternal outcomes of COVID-19 infection during pregnancy and advocates for pregnant women to be recognized as a vulnerable group during the current pandemic.", "doi": "10.1186/s12884-020-03172-8", "pmid": "32887569", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12884-020-03172-8"}, {"db": "pmc", "key": "PMC7472409"}], "notes": [], "created": "2020-12-06T07:29:06.065Z", "modified": "2021-02-26T08:45:48.066Z"}, {"entity": "publication", "iuid": "6de1c1add6e94b78b6239f786907ce70", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6de1c1add6e94b78b6239f786907ce70.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6de1c1add6e94b78b6239f786907ce70"}}, "title": "Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline (updated version).", "authors": [{"family": "Jin", "given": "Ying-Hui", "initials": "YH"}, {"family": "Zhan", "given": "Qing-Yuan", "initials": "QY"}, {"family": "Peng", "given": "Zhi-Yong", "initials": "ZY"}, {"family": "Ren", "given": "Xue-Qun", "initials": "XQ"}, {"family": "Yin", "given": "Xun-Tao", "initials": "XT"}, {"family": "Cai", "given": "Lin", "initials": "L"}, {"family": "Yuan", "given": "Yu-Feng", "initials": "YF"}, {"family": "Yue", "given": "Ji-Rong", "initials": "JR"}, {"family": "Zhang", "given": "Xiao-Chun", "initials": "XC"}, {"family": "Yang", "given": "Qi-Wen", "initials": "QW"}, {"family": "Ji", "given": "Jianguang", "initials": "J"}, {"family": "Xia", "given": "Jian", "initials": "J"}, {"family": "Li", "given": "Yi-Rong", "initials": "YR"}, {"family": "Zhou", "given": "Fu-Xiang", "initials": "FX"}, {"family": "Gao", "given": "Ya-Dong", "initials": "YD"}, {"family": "Yu", "given": "Zhui", "initials": "Z"}, {"family": "Xu", "given": "Feng", "initials": "F"}, {"family": "Tu", "given": "Ming-Li", "initials": "ML"}, {"family": "Tan", "given": "Li-Ming", "initials": "LM"}, {"family": "Yang", "given": "Min", "initials": "M"}, {"family": "Chen", "given": "Fang", "initials": "F"}, {"family": "Zhang", "given": "Xiao-Ju", "initials": "XJ"}, {"family": "Zeng", "given": "Mei", "initials": "M"}, {"family": "Zhu", "given": "Yu", "initials": "Y"}, {"family": "Liu", "given": "Xin-Can", "initials": "XC"}, {"family": "Yang", "given": "Jian", "initials": "J"}, {"family": "Zhao", "given": "Dong-Chi", "initials": "DC"}, {"family": "Ding", "given": "Yu-Feng", "initials": "YF"}, {"family": "Hou", "given": "Ning", "initials": "N"}, {"family": "Wang", "given": "Fu-Bing", "initials": "FB"}, {"family": "Chen", "given": "Hao", "initials": "H"}, {"family": "Zhang", "given": "Yong-Gang", "initials": "YG"}, {"family": "Li", "given": "Wei", "initials": "W"}, {"family": "Chen", "given": "Wen", "initials": "W"}, {"family": "Shi", "given": "Yue-Xian", "initials": "YX"}, {"family": "Yang", "given": "Xiu-Zhi", "initials": "XZ"}, {"family": "Wang", "given": "Xue-Jun", "initials": "XJ"}, {"family": "Zhong", "given": "Yan-Jun", "initials": "YJ"}, {"family": "Zhao", "given": "Ming-Juan", "initials": "MJ"}, {"family": "Li", "given": "Bing-Hui", "initials": "BH"}, {"family": "Ma", "given": "Lin-Lu", "initials": "LL"}, {"family": "Zi", "given": "Hao", "initials": "H"}, {"family": "Wang", "given": "Na", "initials": "N"}, {"family": "Wang", "given": "Yun-Yun", "initials": "YY"}, {"family": "Yu", "given": "Shao-Fu", "initials": "SF"}, {"family": "Li", "given": "Lu-Yao", "initials": "LY"}, {"family": "Huang", "given": "Qiao", "initials": "Q"}, {"family": "Weng", "given": "Hong", "initials": "H"}, {"family": "Ren", "given": "Xiang-Ying", "initials": "XY"}, {"family": "Luo", "given": "Li-Sha", "initials": "LS"}, {"family": "Fan", "given": "Man-Ru", "initials": "MR"}, {"family": "Huang", "given": "Di", "initials": "D"}, {"family": "Xue", "given": "Hong-Yang", "initials": "HY"}, {"family": "Yu", "given": "Lin-Xin", "initials": "LX"}, {"family": "Gao", "given": "Jin-Ping", "initials": "JP"}, {"family": "Deng", "given": "Tong", "initials": "T"}, {"family": "Zeng", "given": "Xian-Tao", "initials": "XT", "orcid": "0000-0003-1262-725X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6ac51af3f0b4269b2d7ad82fd726e09.json"}}, {"family": "Li", "given": "Hong-Jun", "initials": "HJ"}, {"family": "Cheng", "given": "Zhen-Shun", "initials": "ZS"}, {"family": "Yao", "given": "Xiaomei", "initials": "X"}, {"family": "Wang", "given": "Xing-Huan", "initials": "XH"}, {"family": "Evidence-Based Medicine Chapter of China International Exchange and Promotive Association for Medical and Health Care (CPAM)", "given": "", "initials": ""}, {"family": "Chinese Research Hospital Association (CRHA)", "given": "", "initials": ""}], "type": "journal article", "published": "2020-09-04", "journal": {"title": "Mil Med Res", "issn": "2054-9369", "volume": "7", "issue": "1", "pages": "41", "issn-l": null}, "abstract": "The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, coronavirus disease 2019 (COVID-19), affecting more than seventeen million people around the world. Diagnosis and treatment guidelines for clinicians caring for patients are needed. In the early stage, we have issued \"A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)\"; now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline. We formed a working group of clinical experts and methodologists. The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas: chemoprophylaxis, diagnosis, treatments, and discharge management. We searched the literature for direct evidence on the management of COVID-19, and assessed its certainty generated recommendations using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Recommendations were either strong or weak, or in the form of ungraded consensus-based statement. Finally, we issued 34 statements. Among them, 6 were strong recommendations for, 14 were weak recommendations for, 3 were weak recommendations against and 11 were ungraded consensus-based statement. They covered topics of chemoprophylaxis (including agents and Traditional Chinese Medicine (TCM) agents), diagnosis (including clinical manifestations, reverse transcription-polymerase chain reaction (RT-PCR), respiratory tract specimens, IgM and IgG antibody tests, chest computed tomography, chest x-ray, and CT features of asymptomatic infections), treatments (including lopinavir-ritonavir, umifenovir, favipiravir, interferon, remdesivir, combination of antiviral drugs, hydroxychloroquine/chloroquine, interleukin-6 inhibitors, interleukin-1 inhibitors, glucocorticoid, qingfei paidu decoction, lianhua qingwen granules/capsules, convalescent plasma, lung transplantation, invasive or noninvasive ventilation, and extracorporeal membrane oxygenation (ECMO)), and discharge management (including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge). We also created two figures of these recommendations for the implementation purpose. We hope these recommendations can help support healthcare workers caring for COVID-19 patients.", "doi": "10.1186/s40779-020-00270-8", "pmid": "32887670", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7472403"}, {"db": "pii", "key": "10.1186/s40779-020-00270-8"}], "notes": [], "created": "2020-12-06T07:27:19.354Z", "modified": "2023-06-19T15:37:30.085Z"}, {"entity": "publication", "iuid": "c405a953cb044229a5b18e6351e3e1fe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c405a953cb044229a5b18e6351e3e1fe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c405a953cb044229a5b18e6351e3e1fe"}}, "title": "An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.", "authors": [{"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Vidakovics Perez", "given": "Laura", "initials": "L"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Das", "given": "Hrishikesh", "initials": "H"}, {"family": "Schulte", "given": "Tim", "initials": "T"}, {"family": "Moliner-Morro", "given": "Ainhoa", "initials": "A"}, {"family": "Corcoran", "given": "Martin", "initials": "M"}, {"family": "Achour", "given": "Adnane", "initials": "A"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "H\u00e4llberg", "given": "B Martin", "initials": "BM"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}], "type": "journal article", "published": "2020-09-04", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "11", "issue": "1", "pages": "4420"}, "abstract": "SARS-CoV-2 enters host cells through an interaction between the spike glycoprotein and the angiotensin converting enzyme 2 (ACE2) receptor. Directly preventing this interaction presents an attractive possibility for suppressing SARS-CoV-2 replication. Here, we report the isolation and characterization of an alpaca-derived single domain antibody fragment, Ty1, that specifically targets the receptor binding domain (RBD) of the SARS-CoV-2 spike, directly preventing ACE2 engagement. Ty1 binds the RBD with high affinity, occluding ACE2. A cryo-electron microscopy structure of the bound complex at 2.9 \u00c5 resolution reveals that Ty1 binds to an epitope on the RBD accessible in both the 'up' and 'down' conformations, sterically hindering RBD-ACE2 binding. While fusion to an Fc domain renders Ty1 extremely potent, Ty1 neutralizes SARS-CoV-2 spike pseudovirus as a 12.8 kDa nanobody, which can be expressed in high quantities in bacteria, presenting opportunities for manufacturing at scale. Ty1 is therefore an excellent candidate as an intervention against COVID-19.", "doi": "10.1038/s41467-020-18174-5", "pmid": "32887876", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: H2020": null, "Category: Biochemistry": null}, "xrefs": [{"db": "GENBANK", "key": "MT784731", "description": "Sequence of Ty1"}, {"db": "URL", "key": "https://github.com/derpaule/Ty1_octet_itc", "description": "ITC data"}, {"db": "URL", "key": "https://github.com/MurrellGroup/Ty1", "description": "Jupyter notebooks to reproduce the NGS data processing"}, {"db": "URL", "key": "https://www.ebi.ac.uk/pdbe/entry/emdb/EMD-11526", "description": "EMDB EMD-11526: Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing nanobodies"}, {"db": "PDB", "key": "6ZXN", "description": "Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing nanobodies (Ty1)"}, {"db": "BioProject", "key": "PRJNA638614", "description": "Next generation sequencing data"}], "notes": [], "created": "2020-10-28T09:09:58.686Z", "modified": "2021-02-26T08:45:03.240Z"}, {"entity": "publication", "iuid": "ed6938f129a644cdb6b4c4b232d3dbd8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed6938f129a644cdb6b4c4b232d3dbd8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed6938f129a644cdb6b4c4b232d3dbd8"}}, "title": "Outcomes of COVID-19 in patients with CLL: a multicenter international experience.", "authors": [{"family": "Mato", "given": "Anthony R", "initials": "AR"}, {"family": "Roeker", "given": "Lindsey E", "initials": "LE"}, {"family": "Lamanna", "given": "Nicole", "initials": "N"}, {"family": "Allan", "given": "John N", "initials": "JN"}, {"family": "Leslie", "given": "Lori", "initials": "L"}, {"family": "Pagel", "given": "John M", "initials": "JM"}, {"family": "Patel", "given": "Krish", "initials": "K"}, {"family": "Osterborg", "given": "Anders", "initials": "A"}, {"family": "Wojenski", "given": "Daniel", "initials": "D"}, {"family": "Kamdar", "given": "Manali", "initials": "M"}, {"family": "Huntington", "given": "Scott F", "initials": "SF"}, {"family": "Davids", "given": "Matthew S", "initials": "MS"}, {"family": "Brown", "given": "Jennifer R", "initials": "JR"}, {"family": "Antic", "given": "Darko", "initials": "D"}, {"family": "Jacobs", "given": "Ryan", "initials": "R"}, {"family": "Ahn", "given": "Inhye E", "initials": "IE"}, {"family": "Pu", "given": "Jeffrey", "initials": "J"}, {"family": "Isaac", "given": "Krista M", "initials": "KM"}, {"family": "Barr", "given": "Paul M", "initials": "PM"}, {"family": "Ujjani", "given": "Chaitra S", "initials": "CS"}, {"family": "Geyer", "given": "Mark B", "initials": "MB"}, {"family": "Berman", "given": "Ellin", "initials": "E"}, {"family": "Zelenetz", "given": "Andrew D", "initials": "AD"}, {"family": "Malakhov", "given": "Nikita", "initials": "N"}, {"family": "Furman", "given": "Richard R", "initials": "RR"}, {"family": "Koropsak", "given": "Michael", "initials": "M"}, {"family": "Bailey", "given": "Neil", "initials": "N"}, {"family": "Hanson", "given": "Lotta", "initials": "L"}, {"family": "Perini", "given": "Guilherme F", "initials": "GF"}, {"family": "Ma", "given": "Shuo", "initials": "S"}, {"family": "Ryan", "given": "Christine E", "initials": "CE"}, {"family": "Wiestner", "given": "Adrian", "initials": "A"}, {"family": "Portell", "given": "Craig A", "initials": "CA"}, {"family": "Shadman", "given": "Mazyar", "initials": "M"}, {"family": "Chong", "given": "Elise A", "initials": "EA"}, {"family": "Brander", "given": "Danielle M", "initials": "DM"}, {"family": "Sundaram", "given": "Suchitra", "initials": "S"}, {"family": "Seddon", "given": "Amanda N", "initials": "AN"}, {"family": "Seymour", "given": "Erlene", "initials": "E"}, {"family": "Patel", "given": "Meera", "initials": "M"}, {"family": "Martinez-Calle", "given": "Nicolas", "initials": "N"}, {"family": "Munir", "given": "Talha", "initials": "T"}, {"family": "Walewska", "given": "Renata", "initials": "R"}, {"family": "Broom", "given": "Angus", "initials": "A"}, {"family": "Walter", "given": "Harriet", "initials": "H"}, {"family": "El-Sharkawi", "given": "Dima", "initials": "D"}, {"family": "Parry", "given": "Helen", "initials": "H"}, {"family": "Wilson", "given": "Matthew R", "initials": "MR"}, {"family": "Patten", "given": "Piers E M", "initials": "PEM"}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jos\u00e9-\u00c1ngel", "initials": "J\u00c1"}, {"family": "Miras", "given": "Fatima", "initials": "F"}, {"family": "Fern\u00e1ndez Escalada", "given": "Noemi", "initials": "N"}, {"family": "Ghione", "given": "Paola", "initials": "P"}, {"family": "Nabhan", "given": "Chadi", "initials": "C"}, {"family": "Lebowitz", "given": "Sonia", "initials": "S"}, {"family": "Bhavsar", "given": "Erica", "initials": "E"}, {"family": "L\u00f3pez-Jim\u00e9nez", "given": "Javier", "initials": "J"}, {"family": "Naya", "given": "Daniel", "initials": "D"}, {"family": "Garcia-Marco", "given": "Jose Antonio", "initials": "JA"}, {"family": "Sk\u00e5nland", "given": "Sigrid S", "initials": "SS"}, {"family": "Cordoba", "given": "Raul", "initials": "R"}, {"family": "Eyre", "given": "Toby A", "initials": "TA"}], "type": "clinical trial", "published": "2020-09-03", "journal": {"title": "Blood", "issn": "1528-0020", "volume": "136", "issue": "10", "pages": "1134-1143", "issn-l": null}, "abstract": "Given advanced age, comorbidities, and immune dysfunction, chronic lymphocytic leukemia (CLL) patients may be at particularly high risk of infection and poor outcomes related to coronavirus disease 2019 (COVID-19). Robust analysis of outcomes for CLL patients, particularly examining effects of baseline characteristics and CLL-directed therapy, is critical to optimally manage CLL patients through this evolving pandemic. CLL patients diagnosed with symptomatic COVID-19 across 43 international centers (n = 198) were included. Hospital admission occurred in 90%. Median age at COVID-19 diagnosis was 70.5 years. Median Cumulative Illness Rating Scale score was 8 (range, 4-32). Thirty-nine percent were treatment naive (\"watch and wait\"), while 61% had received \u22651 CLL-directed therapy (median, 2; range, 1-8). Ninety patients (45%) were receiving active CLL therapy at COVID-19 diagnosis, most commonly Bruton tyrosine kinase inhibitors (BTKi's; n = 68/90 [76%]). At a median follow-up of 16 days, the overall case fatality rate was 33%, though 25% remain admitted. Watch-and-wait and treated cohorts had similar rates of admission (89% vs 90%), intensive care unit admission (35% vs 36%), intubation (33% vs 25%), and mortality (37% vs 32%). CLL-directed treatment with BTKi's at COVID-19 diagnosis did not impact survival (case fatality rate, 34% vs 35%), though the BTKi was held during the COVID-19 course for most patients. These data suggest that the subgroup of CLL patients admitted with COVID-19, regardless of disease phase or treatment status, are at high risk of death. Future epidemiologic studies are needed to assess severe acute respiratory syndrome coronavirus 2 infection risk, these data should be validated independently, and randomized studies of BTKi's in COVID-19 are needed to provide definitive evidence of benefit.", "doi": "10.1182/blood.2020006965", "pmid": "32688395", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "461426"}, {"db": "pmc", "key": "PMC7472711"}], "notes": [], "created": "2020-12-07T16:30:16.839Z", "modified": "2021-02-26T08:45:03.331Z"}, {"entity": "publication", "iuid": "7b945315d0934beba3a131f7efdb347c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b945315d0934beba3a131f7efdb347c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b945315d0934beba3a131f7efdb347c"}}, "title": "Inadequate prophylactic effect of low-molecular weight heparin in critically ill COVID-19 patients.", "authors": [{"family": "Stattin", "given": "K", "initials": "K"}, {"family": "Lipcsey", "given": "M", "initials": "M"}, {"family": "Andersson", "given": "H", "initials": "H"}, {"family": "Pont\u00e9n", "given": "E", "initials": "E"}, {"family": "B\u00fclow Anderberg", "given": "S", "initials": "S"}, {"family": "Gradin", "given": "A", "initials": "A"}, {"family": "Larsson", "given": "A", "initials": "A"}, {"family": "Lubenow", "given": "N", "initials": "N"}, {"family": "von Seth", "given": "M", "initials": "M"}, {"family": "Rubertsson", "given": "S", "initials": "S"}, {"family": "Hultstr\u00f6m", "given": "M", "initials": "M"}, {"family": "Frithiof", "given": "R", "initials": "R"}], "type": "journal article", "published": "2020-09-03", "journal": {"title": "J Crit Care", "issn": "1557-8615", "issn-l": "0883-9441", "volume": "60", "issue": null, "pages": "249-252"}, "abstract": "The aim of this study was to investigate potential markers of coagulopathy and the effects of thromboprophylaxis with low-molecular-weight heparin (LMWH) on thromboelastography (TEG) and anti-factor Xa in critically ill COVID-19 patients.\r\n\r\nWe conducted a prospective study in 31 consecutive adult intensive care unit (ICU) patients. TEG with and without heparinase and anti-factor Xa analysis were performed. Standard thromboprophylaxis was given with dalteparin (75-100 IU/kg subcutaneously).\r\n\r\nFive patients (16%) had symptomatic thromboembolic events. All patients had a maximum amplitude (MA) > 65 mm and 13 (42%) had MA > 72 mm at some point during ICU stay. Anti-factor Xa activity were below the target range in 23% of the patients and above target range in 46% of patients. There was no significant correlation between dalteparin dose and anti-factor Xa activity.\r\n\r\nPatients with COVID-19 have hypercoagulability with high MA on TEG. The effect of LMWH on thromboembolic disease, anti-factor Xa activity and TEG was variable and could not be reliably predicted. This indicates that standard prophylactic doses of LMWH may be insufficient. Monitoring coagulation and the LMWH effect is important in patients with COVID-19 but interpreting the results in relation to risk of thromboembolic disease poses difficulties.", "doi": "10.1016/j.jcrc.2020.08.026", "pmid": "32920503", "labels": {"Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-04T15:28:40.388Z", "modified": "2021-02-26T08:45:48.368Z"}, {"entity": "publication", "iuid": "e9ec5321a98b4d0a8c212629069c6a8a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e9ec5321a98b4d0a8c212629069c6a8a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e9ec5321a98b4d0a8c212629069c6a8a"}}, "title": "Factors contributing to healthcare professional burnout during the COVID-19 pandemic: A rapid turnaround global survey", "authors": [{"family": "Morgantini", "given": "Luca A", "initials": "LA"}, {"family": "Naha", "given": "Ushasi", "initials": "U"}, {"family": "Wang", "given": "Heng", "initials": "H"}, {"family": "Francavilla", "given": "Simone", "initials": "S"}, {"family": "Acar", "given": "\u00d6mer", "initials": "\u00d6"}, {"family": "Flores", "given": "Jose M", "initials": "JM"}, {"family": "Crivellaro", "given": "Simone", "initials": "S"}, {"family": "Moreira", "given": "Daniel", "initials": "D"}, {"family": "Abern", "given": "Michael", "initials": "M"}, {"family": "Eklund", "given": "Martin", "initials": "M"}, {"family": "Vigneswaran", "given": "Hari T", "initials": "HT"}, {"family": "Weine", "given": "Stevan M", "initials": "SM"}], "type": "journal-article", "published": "2020-09-03", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "15", "issue": "9", "pages": "e0238217", "issn-l": "1932-6203"}, "abstract": null, "doi": "10.1371/journal.pone.0238217", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.1371/journal.pone.0238217.s006", "description": "Individual-level data on exposure, perception, and workload collected from 2,707 healthcare professionals from 60 countries"}], "notes": [], "created": "2021-01-26T15:12:12.627Z", "modified": "2021-02-26T08:47:00.279Z"}, {"entity": "publication", "iuid": "19e9898a4a93451b8319e13cc3ea055f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19e9898a4a93451b8319e13cc3ea055f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19e9898a4a93451b8319e13cc3ea055f"}}, "title": "COVID-19 pandemic: implementing control measures in Africa using the 'SHEF2' model.", "authors": [{"family": "Wirsiy", "given": "Frankline Sevidzem", "initials": "FS"}, {"family": "Nkfusai", "given": "Claude Ngwayu", "initials": "CN"}, {"family": "Ako-Arrey", "given": "Denis Ebot", "initials": "DE"}, {"family": "Yeika", "given": "Eugene Vernyuy", "initials": "EV"}, {"family": "Manjong", "given": "Florence Titu", "initials": "FT"}, {"family": "Esther", "given": "Dongmo Kenfack", "initials": "DK"}, {"family": "Nzoyom", "given": "Rosette Boseme", "initials": "RB"}, {"family": "Atuhaire", "given": "Catherine", "initials": "C"}, {"family": "Wirsiy", "given": "Jean-Claude Kindzeka", "initials": "JK"}, {"family": "Cumber", "given": "Samuel Nambile", "initials": "SN"}], "type": "journal article", "published": "2020-09-03", "journal": {"title": "Pan Afr Med J", "issn": "1937-8688", "volume": "37", "issue": "Suppl 1", "pages": "3", "issn-l": null}, "abstract": "The COVID-19 Pandemic in Africa is a severe reminder of the brunt of emerging and re-emerging infectious pathogens and the need for simple, context-oriented, and sustainable health models to combat them when the need arises. In this commentary, an analytical discursive approach was chosen to owe to Africa's unique situation of weak health systems, with most of its member states showing an initial reluctance to deal openly with the COVID-19 situation. This paper discusses five major control measures doped the SHEF2 Model i.e. (\"SHEF2\"- S: Social distancing, H: Hands, E: Elbows, F: Face, F: Feel) of COVID-19 implemented in Africa. We also review the issues related to implementing SHEF2 control measures in Africa. The measures being taken in Asia, Europe, and North America such as social distancing and regular hand washing are a particular challenge for African countries with dense populations, unequal access to water, and limited social safety nets. COVID-19 is challenging the public health and socio-political systems of all affected African countries. The burden of COVID-19 demands rapid and decisive action to be taken, yet the comparison shows how difficult it is was for an unknown new coronavirus disease. In line with the steps being taken across the globe to control and contain COVID-19 pandemic, African countries are preparing for the great effects of this pandemic and ensuing deep recession thus the reason we assert, the greater hope for African countries is implementing an aggressive SHEF2 model strategy. The spread of the pandemic will eventually stop, and the international system will find a balance, but most of the damage will be felt particularly by Africa.", "doi": "10.11604/pamj.supp.2020.37.3.24057", "pmid": "33294104", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "PAMJ-37-1-3"}, {"db": "pmc", "key": "PMC7704345"}], "notes": [], "created": "2020-12-10T09:11:44.724Z", "modified": "2020-12-10T09:13:01.588Z"}, {"entity": "publication", "iuid": "60868faf0ee247319d300b5aaf777e16", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60868faf0ee247319d300b5aaf777e16.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60868faf0ee247319d300b5aaf777e16"}}, "title": "A Thematic Analysis of Weibo Topics (Chinese Twitter Hashtags) regarding Older Adults During the COVID-19 Outbreak.", "authors": [{"family": "Xi", "given": "Wanyu", "initials": "W"}, {"family": "Xu", "given": "Wenqian", "initials": "W"}, {"family": "Zhang", "given": "Xin", "initials": "X"}, {"family": "Ayalon", "given": "Liat", "initials": "L"}], "type": "journal article", "published": "2020-09-03", "journal": {"title": "J Gerontol B Psychol Sci Soc Sci", "issn": "1758-5368", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "We explored the portrayal of older adults and the public response to topics concerning older adults during the COVID-19 pandemic in Chinese social media (Weibo topics, equivalent to hashtags on Twitter). We also explored the temporal trends of dominant themes to identify changes over time.\r\n\r\nTopics related to older adults were searched in the Weibo topic search engine between January 20 and April 28, 2020. Overall, 241 topics and their view frequency and comment frequency were collected. Inductive thematic analysis was conducted to classify the topics into themes. The popularity of each theme was also analyzed. In addition, the frequency with which each theme appeared during the three major stages of the pandemic (outbreak, turnover, post-peak) was reported.\r\n\r\nSix main themes were identified. \"Older adults contributing to the community\" was the most prominent theme with the highest average comment frequency per topic. It was also the most dominant theme in the first stage of the pandemic. \"Older patients in hospitals\" was the second most prominent theme, and the most dominant theme in the second and third stages of the pandemic. The percentage of topics with the themes \"Care recipients\" and \"Older adults caring for the young\" increased over time.\r\n\r\nThe portrayal of older people as being warm, competent, and actively exercising their agency is prevalent on Weibo. The Weibo-viewing public shows signs of interest in intergenerational solidarity during the pandemic in China. These findings are different from findings reported by studies conducted in the West.", "doi": "10.1093/geronb/gbaa148", "pmid": "32882029", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "5901075"}, {"db": "pmc", "key": "PMC7499682"}], "notes": [], "created": "2020-12-06T07:31:38.507Z", "modified": "2022-11-10T06:42:21.409Z"}, {"entity": "publication", "iuid": "b117f2dd395849ec983cbe9cebb6bedd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b117f2dd395849ec983cbe9cebb6bedd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b117f2dd395849ec983cbe9cebb6bedd"}}, "title": "Rhabdomyolysis and acute kidney injury in severe COVID-19 infection.", "authors": [{"family": "Taxbro", "given": "Knut", "initials": "K"}, {"family": "Kahlow", "given": "Hannes", "initials": "H"}, {"family": "Wulcan", "given": "Hannes", "initials": "H"}, {"family": "Fornarve", "given": "Anna", "initials": "A"}], "type": "case reports", "published": "2020-09-02", "journal": {"title": "BMJ Case Rep", "issn": "1757-790X", "volume": "13", "issue": "9", "issn-l": null}, "abstract": "We report the case of a 38-year-old man who presented to the emergency department with fever, myalgia, nausea, vomiting, dry cough, breathlessness and abdominal pain. He was admitted due to hypoxaemia and was diagnosed with SARS-CoV-2 and was subsequently referred to the intensive care unit for intubation and mechanical ventilation. Severe rhabdomyolysis and acute kidney injury developed 4 days later and were suspected after noticing discolouration of the urine and a marked increase in plasma myoglobin levels. Treatment included hydration, forced diuresis and continuous renal replacement therapy. In addition to the coronavirus disease acute respiratory distress syndrome, he was diagnosed with possible SARS-CoV-2-induced myositis with severe rhabdomyolysis and kidney failure. The patient survived and was discharged from intensive care after 12 days, returning home 23 days after hospitalisation, fully mobilised with a partially restored kidney function.", "doi": "10.1136/bcr-2020-237616", "pmid": "32878841", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "13/9/e237616"}, {"db": "pmc", "key": "PMC7470512"}], "notes": [], "created": "2020-12-06T07:33:40.982Z", "modified": "2021-02-26T08:45:48.586Z"}, {"entity": "publication", "iuid": "70967c8fd05941d09e83d78ea1c0a572", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70967c8fd05941d09e83d78ea1c0a572.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70967c8fd05941d09e83d78ea1c0a572"}}, "title": "Implementation researchers can improve the responses of services to the COVID-19 pandemic.", "authors": [{"family": "\u00d8vretveit", "given": "John", "initials": "J"}], "type": "journal article", "published": "2020-09-02", "journal": {"title": "Implement Res Pract", "issn": "2633-4895", "volume": "1", "pages": "2633489520949151", "issn-l": null}, "abstract": "This article describes a rapid implementation research project with the Stockholm health care system to assist the system to respond to the COVID-19 pandemic. It uses this example to illustrate some ways in which implementation research and knowledge can contribute to improving service responses to the pandemic and its consequences as these evolve over the coming months. A sub-specialty of rapid implementation science is proposed to provide practical assistance and as one way to develop implementation research.\n\nThis article describes a rapid implementation research project with the Stockholm health care system to assist the system to respond to the COVID-19 pandemic. It uses this example to illustrate some ways in which implementation research and knowledge can contribute to improving service responses to the pandemic and its consequences as these evolve over the coming months. A sub-specialty of rapid implementation science is proposed to provide practical assistance and as one way to develop implementation research.", "doi": "10.1177/2633489520949151", "pmid": "34192265", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1177_2633489520949151"}, {"db": "pmc", "key": "PMC7468666"}], "notes": [], "created": "2021-07-05T14:27:05.143Z", "modified": "2021-07-05T14:27:05.167Z"}, {"entity": "publication", "iuid": "e759bb7be15443c9ada587d3b408877b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e759bb7be15443c9ada587d3b408877b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e759bb7be15443c9ada587d3b408877b"}}, "title": "Excess cardiovascular deaths in the beginning of COVID-19 outbreak", "authors": [{"family": "Wang", "given": "Junren", "initials": "J"}, {"family": "Zhu", "given": "Jianwei", "initials": "J"}, {"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Sun", "given": "Yajing", "initials": "Y"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "Qu", "given": "Yuanyuan", "initials": "Y"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "posted-content", "published": "2020-09-02", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.08.29.20184317", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-09T19:23:35.863Z", "modified": "2021-06-09T19:23:56.032Z"}, {"entity": "publication", "iuid": "2bc302a6f4a44f5d87ded89cf06c3b6e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2bc302a6f4a44f5d87ded89cf06c3b6e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2bc302a6f4a44f5d87ded89cf06c3b6e"}}, "title": "Coronavirus Disease 2019 Related Clinical Studies: A Cross-Sectional Analysis.", "authors": [{"family": "Ma", "given": "Lin-Lu", "initials": "LL"}, {"family": "Yin", "given": "Xuan", "initials": "X"}, {"family": "Li", "given": "Bing-Hui", "initials": "BH"}, {"family": "Yang", "given": "Jia-Yu", "initials": "JY"}, {"family": "Jin", "given": "Ying-Hui", "initials": "YH"}, {"family": "Huang", "given": "Di", "initials": "D"}, {"family": "Deng", "given": "Tong", "initials": "T"}, {"family": "Wang", "given": "Yun-Yun", "initials": "YY"}, {"family": "Ren", "given": "Xue-Qun", "initials": "XQ"}, {"family": "Ji", "given": "Jianguang", "initials": "J"}, {"family": "Zeng", "given": "Xian-Tao", "initials": "XT"}], "type": "journal article", "published": "2020-09-02", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "11", "issue": null, "pages": "540187", "issn-l": "1663-9812"}, "abstract": "The quality and rationality of many recently registered clinical studies related to coronavirus disease 2019 (COVID-19) needs to be assessed. Hence, this study aims to evaluate the current status of COVID-19 related registered clinical trial.\n\nWe did an electronic search of COVID-19 related clinical studies registered between December 1, 2019 and February 21, 2020 (updated to May 28, 2020) from the ClinicalTrials.gov, and collected registration information, study details, recruitment status, characteristics of the subjects, and relevant information about the trial implementation process.\n\nA total of 1,706 studies were included 10.0% of which (n=171) were from France, 943 (55.3%) used an interventional design, and 600 (35.2%) used an observational design. Most of studies (73.6%) aimed to recruit fewer than 500 people. Interferon was the main prevention program, and antiviral drugs were the main treatment program. Hydroxychloroquine and chloroquine (230/943, 24.4%) were widely studied. Some registered clinical trials are incomplete in content, and 37.4% of the 1,706 studies may have had insufficient sample size.\n\nThe quality of COVID-19 related studies needs to be improved by strengthening the registration process and improving the quality of clinical study protocols so that these clinical studies can provide high-quality clinical evidence related to COVID-19.", "doi": "10.3389/fphar.2020.540187", "pmid": "32982751", "labels": {"Type: Journal article": null, "Category: Imaging": null}, "xrefs": [{"db": "pmc", "key": "PMC7492524"}], "notes": [], "created": "2020-12-03T09:36:21.593Z", "modified": "2021-02-26T08:45:36.589Z"}, {"entity": "publication", "iuid": "03ecaaa4c4644762a6707bfd95b232a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/03ecaaa4c4644762a6707bfd95b232a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/03ecaaa4c4644762a6707bfd95b232a6"}}, "title": "Oxytocin's anti-inflammatory and proimmune functions in COVID-19: a transcriptomic signature-based approach.", "authors": [{"family": "Imami", "given": "Ali S", "initials": "AS"}, {"family": "O'Donovan", "given": "Sinead M", "initials": "SM"}, {"family": "Creeden", "given": "Justin F", "initials": "JF"}, {"family": "Wu", "given": "Xiaojun", "initials": "X"}, {"family": "Eby", "given": "Hunter", "initials": "H"}, {"family": "McCullumsmith", "given": "Cheryl B", "initials": "CB"}, {"family": "Uvn\u00e4s-Moberg", "given": "Kerstin", "initials": "K"}, {"family": "McCullumsmith", "given": "Robert E", "initials": "RE"}, {"family": "Andari", "given": "Elissar", "initials": "E"}], "type": "journal article", "published": "2020-09-01", "journal": {"title": "Physiol Genomics", "issn": "1531-2267", "volume": "52", "issue": "9", "pages": "401-407", "issn-l": null}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide pandemic, infecting over 16 million people worldwide with a significant mortality rate. However, there is no current Food and Drug Administration-approved drug that treats coronavirus disease 2019 (COVID-19). Damage to T lymphocytes along with the cytokine storm are important factors that lead to exacerbation of clinical cases. Here, we are proposing intravenous oxytocin (OXT) as a candidate for adjunctive therapy for COVID-19. OXT has anti-inflammatory and proimmune adaptive functions. Using the Library of Integrated Network-Based Cellular Signatures (LINCS), we used the transcriptomic signature for carbetocin, an OXT agonist, and compared it to gene knockdown signatures of inflammatory (such as interleukin IL-1\u03b2 and IL-6) and proimmune markers (including T cell and macrophage cell markers like CD40 and ARG1). We found that carbetocin's transcriptomic signature has a pattern of concordance with inflammation and immune marker knockdown signatures that are consistent with reduction of inflammation and promotion and sustaining of immune response. This suggests that carbetocin may have potent effects in modulating inflammation, attenuating T cell inhibition, and enhancing T cell activation. Our results also suggest that carbetocin is more effective at inducing immune cell responses than either lopinavir or hydroxychloroquine, both of which have been explored for the treatment of COVID-19.", "doi": "10.1152/physiolgenomics.00095.2020", "pmid": "32809918", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2020-12-07T12:49:51.761Z", "modified": "2021-02-26T08:45:02.813Z"}, {"entity": "publication", "iuid": "7325494cd545495586695b3c740af140", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7325494cd545495586695b3c740af140.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7325494cd545495586695b3c740af140"}}, "title": "Outcomes of renin-angiotensin-aldosterone system blockers in patients with COVID-19: a systematic review and meta-analysis.", "authors": [{"family": "Greco", "given": "Antonio", "initials": "A"}, {"family": "Buccheri", "given": "Sergio", "initials": "S"}, {"family": "D'Arrigo", "given": "Paolo", "initials": "P"}, {"family": "Calderone", "given": "Dario", "initials": "D"}, {"family": "Agnello", "given": "Federica", "initials": "F"}, {"family": "Monte", "given": "Marco", "initials": "M"}, {"family": "Milluzzo", "given": "Rocco Paolo", "initials": "RP"}, {"family": "Franchina", "given": "Antonio Gabriele", "initials": "AG"}, {"family": "Ingala", "given": "Salvatore", "initials": "S"}, {"family": "Capodanno", "given": "Davide", "initials": "D"}], "type": "letter", "published": "2020-09-01", "journal": {"title": "Eur Heart J Cardiovasc Pharmacother", "issn": "2055-6845", "volume": "6", "issue": "5", "pages": "335-337", "issn-l": "2055-6837"}, "abstract": null, "doi": "10.1093/ehjcvp/pvaa074", "pmid": "32671399", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "5872101"}, {"db": "pmc", "key": "PMC7454531"}], "notes": [], "created": "2020-11-22T09:22:06.498Z", "modified": "2020-11-30T08:45:14.800Z"}, {"entity": "publication", "iuid": "a664bb8435df4fddb58e270ad7c8b581", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a664bb8435df4fddb58e270ad7c8b581.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a664bb8435df4fddb58e270ad7c8b581"}}, "title": "Explaining the homogeneous diffusion of COVID-19 nonpharmaceutical interventions across heterogeneous countries.", "authors": [{"family": "Sebhatu", "given": "Abiel", "initials": "A"}, {"family": "Wennberg", "given": "Karl", "initials": "K"}, {"family": "Arora-Jonsson", "given": "Stefan", "initials": "S"}, {"family": "Lindberg", "given": "Staffan I", "initials": "SI"}], "type": "journal article", "published": "2020-09-01", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "issn-l": "0027-8424", "volume": "117", "issue": "35", "pages": "21201-21208"}, "abstract": "We analyze the adoption of nonpharmaceutical interventions in the Organisation for Economic Co-operation and Development (OECD) countries during the early phase of the coronavirus disease 2019 (COVID-19) pandemic. Given the complexity associated with pandemic decisions, governments are faced with the dilemma of how to act quickly when their core decision-making processes are based on deliberations balancing political considerations. Our findings show that, in times of severe crisis, governments follow the lead of others and base their decisions on what other countries do. Governments in countries with a stronger democratic structure are slower to react in the face of the pandemic but are more sensitive to the influence of other countries. We provide insights for research on international policy diffusion and research on the political consequences of the COVID-19 pandemic.", "doi": "10.1073/pnas.2010625117", "pmid": "32788356", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "2010625117"}, {"db": "pmc", "key": "PMC7474611"}], "notes": [], "created": "2020-11-19T15:05:37.246Z", "modified": "2022-11-10T06:43:30.755Z"}, {"entity": "publication", "iuid": "6e911372463547cb80b4199fe05ce8f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e911372463547cb80b4199fe05ce8f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e911372463547cb80b4199fe05ce8f4"}}, "title": "Effects of COVID-19 lockdown strategies on management of atrial fibrillation.", "authors": [{"family": "Blomstr\u00f6m-Lundqvist", "given": "Carina", "initials": "C"}], "type": "editorial", "published": "2020-09-01", "journal": {"title": "Eur Heart J", "issn": "1522-9645", "volume": "41", "issue": "32", "pages": "3080-3082", "issn-l": "0195-668X"}, "abstract": "Editorial", "doi": "10.1093/eurheartj/ehaa538", "pmid": "32614939", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5866605"}, {"db": "pmc", "key": "PMC7528957"}], "notes": [], "created": "2020-11-22T08:48:19.135Z", "modified": "2020-12-08T15:07:44.115Z"}, {"entity": "publication", "iuid": "7ae6940fde8344e3bbf1e8e26cebc2d6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7ae6940fde8344e3bbf1e8e26cebc2d6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7ae6940fde8344e3bbf1e8e26cebc2d6"}}, "title": "COVID-19: how things change in a short while.", "authors": [{"family": "Stolfo", "given": "Davide", "initials": "D"}, {"family": "Sinagra", "given": "Gianfranco", "initials": "G"}], "type": "journal article", "published": "2020-09-01", "journal": {"title": "Eur Heart J Cardiovasc Pharmacother", "issn": "2055-6845", "volume": "6", "issue": "5", "pages": "280-281", "issn-l": "2055-6837"}, "abstract": null, "doi": "10.1093/ehjcvp/pvaa092", "pmid": "32678899", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5873153"}, {"db": "pmc", "key": "PMC7454535"}], "notes": [], "created": "2020-12-07T16:34:29.256Z", "modified": "2020-12-07T16:34:29.265Z"}, {"entity": "publication", "iuid": "90ec8d01daeb4319862104f8d124424f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90ec8d01daeb4319862104f8d124424f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90ec8d01daeb4319862104f8d124424f"}}, "title": "Avoiding the Banality of Evil in Times of COVID-19: Thinking Differently with a Biopsychosocial Perspective for Future Health and Social Policies Development.", "authors": [{"family": "Leonardi", "given": "Matilde", "initials": "M"}, {"family": "Lee", "given": "Haejung", "initials": "H"}, {"family": "van der Veen", "given": "Sabina", "initials": "S"}, {"family": "Maribo", "given": "Thomas", "initials": "T"}, {"family": "Cuenot", "given": "Marie", "initials": "M"}, {"family": "Simon", "given": "Liane", "initials": "L"}, {"family": "Paltamaa", "given": "Jaana", "initials": "J"}, {"family": "Maart", "given": "Soraya", "initials": "S"}, {"family": "Tucker", "given": "Carole", "initials": "C"}, {"family": "Besstrashnova", "given": "Yanina", "initials": "Y"}, {"family": "Shosmin", "given": "Alexander", "initials": "A"}, {"family": "Cid", "given": "Daniel", "initials": "D"}, {"family": "Almborg", "given": "Ann-Helene", "initials": "AH"}, {"family": "Anttila", "given": "Heidi", "initials": "H"}, {"family": "Yamada", "given": "Shin", "initials": "S"}, {"family": "Frattura", "given": "Lucilla", "initials": "L"}, {"family": "Zavaroni", "given": "Carlo", "initials": "C"}, {"family": "Zhuoying", "given": "Qiu", "initials": "Q"}, {"family": "Martinuzzi", "given": "Andrea", "initials": "A"}, {"family": "Martinuzzi", "given": "Michela", "initials": "M"}, {"family": "Magnani", "given": "Francesca Giulia", "initials": "FG"}, {"family": "Snyman", "given": "Stefanus", "initials": "S"}, {"family": "El Oumri", "given": "Ahmed Amine", "initials": "AA"}, {"family": "Sylvain", "given": "Ndegeya", "initials": "N"}, {"family": "Layton", "given": "Natasha", "initials": "N"}, {"family": "Sykes", "given": "Catherine", "initials": "C"}, {"family": "Saleeby", "given": "Patricia Welch", "initials": "PW"}, {"family": "Winkler", "given": "Andrea Sylvia", "initials": "AS"}, {"family": "de Camargo", "given": "Olaf Kraus", "initials": "OK"}], "type": "journal article", "published": "2020-09-01", "journal": {"title": "SN Compr Clin Med", "issn": "2523-8973", "volume": null, "issue": null, "pages": "1-3", "issn-l": null}, "abstract": "The COVID-19 pandemic provides the opportunity to re-think health policies and health systems approaches by the adoption of a biopsychosocial perspective, thus acting on environmental factors so as to increase facilitators and diminish barriers. Specifically, vulnerable people should not face discrimination because of their vulnerability in the allocation of care or life-sustaining treatments. Adoption of biopsychosocial model helps to identify key elements where to act to diminish effects of the pandemics. The pandemic showed us that barriers in health care organization affect mostly those that are vulnerable and can suffer discrimination not because of severity of diseases but just because of their vulnerability, be this age or disability and this can be avoided by biopsychosocial planning in health and social policies. It is possible to avoid the banality of evil, intended as lack of thinking on what we do when we do, by using the emergence of the emergency of COVID-19 as a Trojan horse to achieve some of the sustainable development goals such as universal health coverage and equity in access, thus acting on environmental factors is the key for global health improvement.", "doi": "10.1007/s42399-020-00486-8", "pmid": "32905109", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "486"}, {"db": "pmc", "key": "PMC7462656"}], "notes": [], "created": "2020-12-03T15:54:02.093Z", "modified": "2020-12-03T15:54:02.118Z"}, {"entity": "publication", "iuid": "70b2e65b6cd84e38a2b89ed18da66416", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70b2e65b6cd84e38a2b89ed18da66416.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70b2e65b6cd84e38a2b89ed18da66416"}}, "title": "Association between eating behavior and quarantine/confinement stressors during the coronavirus disease 2019 outbreak.", "authors": [{"family": "Haddad", "given": "Chadia", "initials": "C"}, {"family": "Zakhour", "given": "Maha", "initials": "M"}, {"family": "Bou Kheir", "given": "Maria", "initials": "M"}, {"family": "Haddad", "given": "Rima", "initials": "R"}, {"family": "Al Hachach", "given": "Myriam", "initials": "M"}, {"family": "Sacre", "given": "Hala", "initials": "H"}, {"family": "Salameh", "given": "Pascale", "initials": "P"}], "type": "journal article", "published": "2020-09-01", "journal": {"title": "J Eat Disord", "issn": "2050-2974", "issn-l": null, "volume": "8", "issue": null, "pages": "40"}, "abstract": "Quarantine/confinement is an effective measure to face the Coronavirus disease 2019 (COVID-19). Consequently, in response to this stressful situation, people confined to their homes may change their everyday eating behavior. Therefore, the primary objective of this study is to evaluate the association between quarantine/confinement stressors and eating behavior during the COVID-19 outbreak. The secondary objective is to compare the association of quarantine/confinement stressors and diet behavior between two groups of participants, those attending diet clinics and those not (general population).\r\n\r\nA cross-sectional web-based online survey carried out between April 3 and 18, 2020, enrolled 407 participants from the Lebanese population. Eating Disorder Examination - Questionnaire (EDE-Q) were used to measure the behavioral features of eating disorders.\r\n\r\nMore than half of the sample (53.0%) abide by the home quarantine/confinement, 95.4% were living with someone in the quarantine/confinement, and 39.6% continued to work from home. Higher fear of COVID-19 was found in 182 (44.8%) participants, higher boredom in 200 (49.2%) participants, higher anger in 187 (46.3%), and higher anxiety in 197 (48.5%) participants. Higher fear of COVID-19 (Beta = 0.02), higher BMI (Beta = 0.05), and physical activity (Beta = 1.04) were significantly associated with a higher restraint score. Higher anxiety, higher fear of COVID-19, higher BMI, practicing physical exercise, and a higher number of adults living in the quarantine/confinement were significantly associated with higher shape and weight concerns.\r\n\r\nOur results showed that the fear of COVID-19 was correlated with more eating restraint, weight, and shape concerns in the whole sample, but more specifically in the dietitian clients group. Public health control measures are needed to reduce the detrimental effects of psychological distress associated with quarantine/confinement on eating behaviors during the COVID-19 outbreak.", "doi": "10.1186/s40337-020-00317-0", "pmid": "32879730", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "317"}, {"db": "pmc", "key": "PMC7458649"}], "notes": [], "created": "2020-12-06T07:32:44.998Z", "modified": "2022-11-10T06:47:03.755Z"}, {"entity": "publication", "iuid": "a8d0a2f042ac48f8ab2a981f039d2479", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8d0a2f042ac48f8ab2a981f039d2479.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8d0a2f042ac48f8ab2a981f039d2479"}}, "title": "Vitamin D deficiency and the COVID-19 pandemic.", "authors": [{"family": "Zemb", "given": "Patrick", "initials": "P"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Camargo", "given": "Carlos A", "initials": "CA"}, {"family": "Cavalier", "given": "Etienne", "initials": "E"}, {"family": "Cormier", "given": "Catherine", "initials": "C"}, {"family": "Courbebaisse", "given": "Marie", "initials": "M"}, {"family": "Hollis", "given": "Bruce", "initials": "B"}, {"family": "Joulia", "given": "Fabrice", "initials": "F"}, {"family": "Minisola", "given": "Salvatore", "initials": "S"}, {"family": "Pilz", "given": "Stefan", "initials": "S"}, {"family": "Pludowski", "given": "Pawel", "initials": "P"}, {"family": "Schmitt", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Zdrenghea", "given": "Mihnea", "initials": "M"}, {"family": "Souberbielle", "given": "Jean-Claude", "initials": "JC"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "J Glob Antimicrob Resist", "issn": "2213-7173", "volume": "22", "issue": null, "pages": "133-134", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jgar.2020.05.006", "pmid": "32474141", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-7165(20)30132-6"}, {"db": "pmc", "key": "PMC7256612"}], "notes": [], "created": "2020-12-09T10:59:00.344Z", "modified": "2020-12-09T10:59:00.366Z"}, {"entity": "publication", "iuid": "b1573fb6875347c485fd5af422886c13", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1573fb6875347c485fd5af422886c13.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1573fb6875347c485fd5af422886c13"}}, "title": "Travel-associated COVID-19: a challenge for surveillance?", "authors": [{"family": "Beaut\u00e9", "given": "Julien", "initials": "J"}, {"family": "Spiteri", "given": "Gianfranco", "initials": "G"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "37", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.37.2001641", "pmid": "32945253", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7502887"}], "notes": [], "created": "2020-12-03T15:26:13.762Z", "modified": "2020-12-03T15:26:13.772Z"}, {"entity": "publication", "iuid": "c168f9f298ba441cb13488e8fa8a9709", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c168f9f298ba441cb13488e8fa8a9709.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c168f9f298ba441cb13488e8fa8a9709"}}, "title": "Transmission of SARS-CoV-2 in children aged 0 to 19 years in childcare facilities and schools after their reopening in May 2020, Baden-W\u00fcrttemberg, Germany.", "authors": [{"family": "Ehrhardt", "given": "J", "initials": "J"}, {"family": "Ekinci", "given": "A", "initials": "A"}, {"family": "Krehl", "given": "H", "initials": "H"}, {"family": "Meincke", "given": "M", "initials": "M"}, {"family": "Finci", "given": "I", "initials": "I"}, {"family": "Klein", "given": "J", "initials": "J"}, {"family": "Geisel", "given": "B", "initials": "B"}, {"family": "Wagner-Wiening", "given": "C", "initials": "C"}, {"family": "Eichner", "given": "M", "initials": "M"}, {"family": "Brockmann", "given": "S O", "initials": "SO"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "36", "issn-l": null}, "abstract": "We investigated data from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected 0-19 year olds, who attended schools/childcare facilities, to assess their role in SARS-CoV-2 transmission after these establishments' reopening in May 2020 in Baden-W\u00fcrttemberg, Germany. Child-to-child transmission in schools/childcare facilities appeared very uncommon. We anticipate that, with face mask use and frequent ventilation of rooms, transmission rates in schools/childcare facilities would remain low in the next term, even if classes' group sizes were increased.", "doi": "10.2807/1560-7917.ES.2020.25.36.2001587", "pmid": "32914746", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7502898"}], "notes": [], "created": "2020-12-03T15:49:58.334Z", "modified": "2021-02-26T08:45:48.653Z"}, {"entity": "publication", "iuid": "88f2b1b690ab477d9fe2589437f08ec1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/88f2b1b690ab477d9fe2589437f08ec1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/88f2b1b690ab477d9fe2589437f08ec1"}}, "title": "Towards pandemic preparedness beyond COVID-19", "authors": [{"family": "Naguib", "given": "Mahmoud M", "initials": "MM"}, {"family": "Ellstr\u00f6m", "given": "Patrik", "initials": "P"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Olsen", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal-article", "published": "2020-09-00", "journal": {"title": "The Lancet Microbe", "issn": "2666-5247", "issn-l": "2666-5247", "volume": "1", "issue": "5", "pages": "e185-e186"}, "abstract": "Review", "doi": "10.1016/s2666-5247(20)30088-4", "pmid": "32838347", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-04T07:08:50.155Z", "modified": "2020-12-11T12:51:10.950Z"}, {"entity": "publication", "iuid": "a9b3c57bb27342faaaa07bd80d8ed5c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a9b3c57bb27342faaaa07bd80d8ed5c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a9b3c57bb27342faaaa07bd80d8ed5c9"}}, "title": "The use of positive end expiratory pressure in patients affected by COVID-19: Time to reconsider the relation between morphology and physiology.", "authors": [{"family": "Perchiazzi", "given": "Gaetano", "initials": "G", "orcid": "0000-0001-6834-6399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ef9ffc76bfe47c5afff104e9aaef020.json"}}, {"family": "Pellegrini", "given": "Mariangela", "initials": "M"}, {"family": "Chiodaroli", "given": "Elena", "initials": "E"}, {"family": "Urits", "given": "Ivan", "initials": "I"}, {"family": "Kaye", "given": "Alan D", "initials": "AD"}, {"family": "Viswanath", "given": "Omar", "initials": "O"}, {"family": "Varrassi", "given": "Giustino", "initials": "G"}, {"family": "Puntillo", "given": "Filomena", "initials": "F"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Best Pract Res Clin Anaesthesiol", "issn": "1878-1608", "volume": "34", "issue": "3", "pages": "561-567", "issn-l": "1753-3740"}, "abstract": "Coronavirus disease 2019 (COVID-19) is a new disease with different phases that can be catastrophic for subpopulations of patients with cardiovascular and pulmonary disease states at baseline. Appreciation for these different phases and treatment modalities, including manipulation of ventilatory settings and therapeutics, has made it a less lethal disease than when it emerged earlier this year. Different aspects of the disease are still largely unknown. However, laboratory investigation and clinical course of the COVID-19 show that this new disease is not a typical acute respiratory distress syndrome process, especially during the first phase. For this reason, the best strategy to be applied is to treat differently the single phases and to support the single functions of the failing organs as they appear.", "doi": "10.1016/j.bpa.2020.07.007", "pmid": "33004167", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7367781"}, {"db": "pii", "key": "S1521-6896(20)30062-8"}], "notes": [], "created": "2020-11-27T12:40:00.890Z", "modified": "2023-06-19T15:20:22.345Z"}, {"entity": "publication", "iuid": "2e1cf5a5227047e5988485212dca347c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e1cf5a5227047e5988485212dca347c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e1cf5a5227047e5988485212dca347c"}}, "title": "The Rheumatologist's Role in the Battle Against COVID-19: Insights from the Front Line and Challenges for the Future.", "authors": [{"family": "Koutsianas", "given": "Christos", "initials": "C"}, {"family": "Chatzidionysiou", "given": "Katerina", "initials": "K"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Mediterr J Rheumatol", "issn": "2529-198X", "volume": "31", "issue": "Suppl 2", "pages": "247-252", "issn-l": "2529-198X"}, "abstract": "As the worldwide burden of COVID-19 increases exponentially, healthcare systems are plagued by unprecedented pressure. In this setting, many rheumatologists across the globe have been recruited to support the front line, facing several unexpected challenges, but also providing valuable skills in combating COVID-19. At the same time, the rheumatic disease patient population may be especially vulnerable to such a rapidly contagious infectious disease and thus needs care and support that has to be provided quickly and efficiently. Clear advice on viral spread mitigation, precise guidelines on immunosuppressive treatment use and alternative methods of providing care, such as telemedicine, are a few of the rheumatologists' new challenges in caring for their patients in the COVID-19 era. Finally, among other specialties, rheumatologists hold a unique place in the fight against the hyper-inflammatory state caused by severe SARS-CoV-2 infection, leading to increased morbidity and mortality. Given their vast experience in the use of biologic and targeted therapies, rheumatologists should lead the way in developing reliable scientific evidence for the optimal treatment of severe COVID-19.", "doi": "10.31138/mjr.31.3.247", "pmid": "33196000", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "MJR-31-Suppl-2-247"}, {"db": "pmc", "key": "PMC7656125"}], "notes": [], "created": "2020-11-27T09:54:48.746Z", "modified": "2020-11-27T09:54:48.765Z"}, {"entity": "publication", "iuid": "7471dd74cf97437cb31db057a3d55c78", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7471dd74cf97437cb31db057a3d55c78.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7471dd74cf97437cb31db057a3d55c78"}}, "title": "The Covid-19 pandemic stress the need to build resilient production ecosystems", "authors": [{"family": "Gordon", "given": "Line J", "initials": "LJ"}], "type": "journal-article", "published": "2020-09-00", "journal": {"title": "Agric Human Values", "issn": "0889-048X", "volume": "37", "issue": "3", "pages": "645-646", "issn-l": null}, "abstract": null, "doi": "10.1007/s10460-020-10105-w", "pmid": "32836746", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10105"}, {"db": "pmc", "key": "PMC7245175"}], "notes": [], "created": "2020-12-07T11:32:08.285Z", "modified": "2021-12-06T13:18:20.606Z"}, {"entity": "publication", "iuid": "9ab6469f5a1445fba99bd72512ac0851", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ab6469f5a1445fba99bd72512ac0851.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ab6469f5a1445fba99bd72512ac0851"}}, "title": "The Association between Out-of-Pocket Expenditure and COVID-19 Mortality Globally.", "authors": [{"family": "El-Khatib", "given": "Ziad", "initials": "Z"}, {"family": "Otu", "given": "Akaninyene", "initials": "A"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}, {"family": "Yaya", "given": "Sanni", "initials": "S"}], "type": "letter", "published": "2020-09-00", "journal": {"title": "J Epidemiol Glob Health", "issn": "2210-6014", "issn-l": null, "volume": "10", "issue": "3", "pages": "192-193"}, "abstract": null, "doi": "10.2991/jegh.k.200725.001", "pmid": "32954706", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "j10/3/192"}, {"db": "pmc", "key": "PMC7509105"}], "notes": [], "created": "2020-12-03T09:27:59.119Z", "modified": "2021-02-26T08:47:00.100Z"}, {"entity": "publication", "iuid": "97292f4104f541cd96c0c9e68bbb847a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/97292f4104f541cd96c0c9e68bbb847a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/97292f4104f541cd96c0c9e68bbb847a"}}, "title": "The \"Vascular Surgery COVID-19 Collaborative\" (VASCC).", "authors": [{"family": "D'Oria", "given": "Mario", "initials": "M"}, {"family": "Mills", "given": "Joseph L", "initials": "JL"}, {"family": "Cohnert", "given": "Tina", "initials": "T"}, {"family": "Oderich", "given": "Gustavo S", "initials": "GS"}, {"family": "Hultgren", "given": "Rebecka", "initials": "R"}, {"family": "Lepidi", "given": "Sandro", "initials": "S"}, {"family": "Vascular Surgery COVID-19 Collaborative (VASCC)", "given": "", "initials": ""}], "type": "letter", "published": "2020-09-00", "journal": {"title": "Eur J Vasc Endovasc Surg", "issn": "1532-2165", "volume": "60", "issue": "3", "pages": "489-490", "issn-l": "1078-5884"}, "abstract": null, "doi": "10.1016/j.ejvs.2020.07.072", "pmid": "32798205", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1078-5884(20)30683-3"}, {"db": "pmc", "key": "PMC7388790"}], "notes": [], "created": "2020-12-07T13:22:26.320Z", "modified": "2020-12-07T13:22:26.330Z"}, {"entity": "publication", "iuid": "c76f6a1bc4f249ad8b183996150078a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c76f6a1bc4f249ad8b183996150078a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c76f6a1bc4f249ad8b183996150078a0"}}, "title": "Targeting TMPRSS2 in SARS-CoV-2 Infection.", "authors": [{"family": "Baughn", "given": "Linda B", "initials": "LB"}, {"family": "Sharma", "given": "Neeraj", "initials": "N"}, {"family": "Elhaik", "given": "Eran", "initials": "E"}, {"family": "Sekulic", "given": "Aleksandar", "initials": "A"}, {"family": "Bryce", "given": "Alan H", "initials": "AH"}, {"family": "Fonseca", "given": "Rafael", "initials": "R"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Mayo Clin Proc", "issn": "1942-5546", "volume": "95", "issue": "9", "pages": "1989-1999", "issn-l": "0025-6196"}, "abstract": "Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has rapidly caused a global pandemic associated with a novel respiratory infection: coronavirus disease-19 (COVID-19). Angiotensin-converting enzyme-2 (ACE2) is necessary to facilitate SARS-CoV-2 infection, but-owing to its essential metabolic roles-it may be difficult to target it in therapies. Transmembrane protease serine 2 (TMPRSS2), which interacts with ACE2, may be a better candidate for targeted therapies. Using publicly available expression data, we show that both ACE2 and TMPRSS2 are expressed in many host tissues, including lung. The highest expression of ACE2 is found in the testes, whereas the prostate displays the highest expression of TMPRSS2. Given the increased severity of disease among older men with SARS-CoV-2 infection, we address the potential roles of ACE2 and TMPRSS2 in their contribution to the sex differences in severity of disease. We show that expression levels of ACE2 and TMPRSS2 are overall comparable between men and women in multiple tissues, suggesting that differences in the expression levels of TMPRSS2 and ACE2 in the lung and other non-sex-specific tissues may not explain the gender disparities in severity of SARS CoV-2. However, given their instrumental roles for SARS-CoV-2 infection and their pleiotropic expression, targeting the activity and expression levels of TMPRSS2 is a rational approach to treat COVID-19.", "doi": "10.1016/j.mayocp.2020.06.018", "pmid": "32861340", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S0025-6196(20)30626-1"}, {"db": "pmc", "key": "PMC7368885"}], "notes": [], "created": "2020-12-07T10:20:25.960Z", "modified": "2021-02-26T08:45:03.245Z"}, {"entity": "publication", "iuid": "ff7fb22175a8472799663bb90467ac15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff7fb22175a8472799663bb90467ac15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff7fb22175a8472799663bb90467ac15"}}, "title": "Prioritizing Cleft/Craniofacial Surgical Care after the COVID-19 Pandemic.", "authors": [{"family": "Breugem", "given": "Corstiaan", "initials": "C"}, {"family": "Smit", "given": "Hans", "initials": "H"}, {"family": "Mark", "given": "Hans", "initials": "H"}, {"family": "Davies", "given": "Gareth", "initials": "G"}, {"family": "Schachner", "given": "Peter", "initials": "P"}, {"family": "Collard", "given": "Mechelle", "initials": "M"}, {"family": "Sell", "given": "Debbie", "initials": "D"}, {"family": "Autelitano", "given": "Luca", "initials": "L"}, {"family": "Rezzonico", "given": "Angela", "initials": "A"}, {"family": "Mazzoleni", "given": "Fabio", "initials": "F"}, {"family": "Novelli", "given": "Giorgio", "initials": "G"}, {"family": "Mossey", "given": "Peter", "initials": "P"}, {"family": "Persson", "given": "Martin", "initials": "M"}, {"family": "Mehendale", "given": "Felicity", "initials": "F"}, {"family": "Gaggl", "given": "Alexander", "initials": "A"}, {"family": "van Gogh", "given": "Christine", "initials": "C"}, {"family": "Zuurbier", "given": "Petra", "initials": "P"}, {"family": "Reinart", "given": "Siegmar", "initials": "S"}, {"family": "de Graaff", "given": "Feike", "initials": "F"}, {"family": "Meazzini", "given": "Costanza", "initials": "C"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Plast Reconstr Surg Glob Open", "issn": "2169-7574", "volume": "8", "issue": "9", "pages": "e3080", "issn-l": null}, "abstract": "It is anticipated that in due course the burden of emergency care due to COVID-19 infected patients will reduce sufficiently to permit elective surgical procedures to recommence. Prioritizing cleft/craniofacial surgery in the already overloaded medical system will then become an issue. The European Cleft Palate Craniofacial Association, together with the European Cleft and Craniofacial Initiative for Equality in Care, performed a brief survey to capture a current snapshot during a rapidly evolving pandemic.\n\nA questionnaire was sent to the 2242 participants who attended 1 of 3 recent international cleft/craniofacial meetings.\n\nThe respondents indicated that children with Robin sequence who were not responding to nonsurgical options should be treated as emergency cases. Over 70% of the respondents indicated that palate repair should be performed before the age of 15 months, an additional 22% stating the same be performed by 18 months. Placement of middle ear tubes, primary cleft lip surgery, alveolar bone grafting, and velopharyngeal insufficiency surgery also need prioritization. Children with craniofacial conditions such as craniosynostosis and increased intracranial pressure need immediate care, whilst children with craniosynostosis and associated obstructive sleep apnea syndrome or proptosis need surgical care within 3 months of the typical timing. Craniosynostosis without signs of increased intracranial pressure needs correction before the age of 18 months.\n\nThis survey indicates several areas of cleft and craniofacial conditions that need prioritization, but also certain areas where intervention is less urgent. We acknowledge that there will be differences in the post COVID-19 response according to circumstances and policies in individual countries.", "doi": "10.1097/GOX.0000000000003080", "pmid": "33133937", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7544383"}], "notes": [], "created": "2020-12-01T15:01:18.453Z", "modified": "2021-02-26T08:45:48.934Z"}, {"entity": "publication", "iuid": "679be0bb5b0c492f8c69165fadf5dfb2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/679be0bb5b0c492f8c69165fadf5dfb2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/679be0bb5b0c492f8c69165fadf5dfb2"}}, "title": "Predicted COVID-19 fatality rates based on age, sex, comorbidities and health system capacity.", "authors": [{"family": "Ghisolfi", "given": "Selene", "initials": "S"}, {"family": "Alm\u00e5s", "given": "Ingvild", "initials": "I"}, {"family": "Sandefur", "given": "Justin C", "initials": "JC"}, {"family": "von Carnap", "given": "Tillman", "initials": "T"}, {"family": "Heitner", "given": "Jesse", "initials": "J"}, {"family": "Bold", "given": "Tessa", "initials": "T"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "5", "issue": "9", "issn-l": "2059-7908"}, "abstract": "Early reports suggest the fatality rate from COVID-19 varies greatly across countries, but non-random testing and incomplete vital registration systems render it impossible to directly estimate the infection fatality rate (IFR) in many low- and middle-income countries. To fill this gap, we estimate the adjustments required to extrapolate estimates of the IFR from high-income to lower-income regions. Accounting for differences in the distribution of age, sex and relevant comorbidities yields substantial differences in the predicted IFR across 21 world regions, ranging from 0.11% in Western Sub-Saharan Africa to 1.07% for high-income Asia Pacific. However, these predictions must be treated as lower bounds in low- and middle-income countries as they are grounded in fatality rates from countries with advanced health systems. To adjust for health system capacity, we incorporate regional differences in the relative odds of infection fatality from childhood respiratory syncytial virus. This adjustment greatly diminishes but does not entirely erase the demography-based advantage predicted in the lowest income settings, with regional estimates of the predicted COVID-19 IFR ranging from 0.37% in Western Sub-Saharan Africa to 1.45% for Eastern Europe.", "doi": "10.1136/bmjgh-2020-003094", "pmid": "32912856", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-003094"}, {"db": "pmc", "key": "PMC7482102"}], "notes": [], "created": "2020-11-27T12:43:18.757Z", "modified": "2020-11-27T12:43:18.768Z"}, {"entity": "publication", "iuid": "0210f1afaeb74e4d9082a7d9ba9f8162", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0210f1afaeb74e4d9082a7d9ba9f8162.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0210f1afaeb74e4d9082a7d9ba9f8162"}}, "title": "Population-level COVID-19 mortality risk for non-elderly individuals overall and for non-elderly individuals without underlying diseases in pandemic epicenters.", "authors": [{"family": "Ioannidis", "given": "John P A", "initials": "JPA"}, {"family": "Axfors", "given": "Cathrine", "initials": "C"}, {"family": "Contopoulos-Ioannidis", "given": "Despina G", "initials": "DG"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Environ Res", "issn": "1096-0953", "issn-l": "0013-9351", "volume": "188", "issue": null, "pages": "109890"}, "abstract": "To provide estimates of the relative rate of COVID-19 death in people <65 years old versus older individuals in the general population, the absolute risk of COVID-19 death at the population level during the first epidemic wave, and the proportion of COVID-19 deaths in non-elderly people without underlying diseases in epicenters of the pandemic.\r\n\r\nCross-sectional survey of countries and US states with at least 800 COVID-19 deaths as of April 24, 2020 and with information on the number of deaths in people with age <65. Data were available for 14 countries (Belgium, Canada, France, Germany, India, Ireland, Italy, Mexico, Netherlands, Portugal, Spain, Sweden, Switzerland, UK) and 13 US states (California, Connecticut, Florida, Georgia, Illinois, Indiana, Louisiana, Maryland, Massachusetts, Michigan, New Jersey, New York, Pennsylvania). We also examined available data on COVID-19 deaths in people with age <65 and no underlying diseases.\r\n\r\nProportion of COVID-19 deaths in people <65 years old; relative mortality rate of COVID-19 death in people <65 versus \u226565 years old; absolute risk of COVID-19 death in people <65 and in those \u226580 years old in the general population as of June 17, 2020; absolute COVID-19 mortality rate expressed as equivalent of mortality rate from driving a motor vehicle.\r\n\r\nIndividuals with age <65 account for 4.5-11.2% of all COVID-19 deaths in European countries and Canada, 8.3-22.7% in the US locations, and were the majority in India and Mexico. People <65 years old had 30- to 100-fold lower risk of COVID-19 death than those \u226565 years old in 11 European countries and Canada, 16- to 52-fold lower risk in US locations, and less than 10-fold in India and Mexico. The absolute risk of COVID-19 death as of June 17, 2020 for people <65 years old in high-income countries ranged from 10 (Germany) to 349 per million (New Jersey) and it was 5 per million in India and 96 per million in Mexico. The absolute risk of COVID-19 death for people \u226580 years old ranged from 0.6 (Florida) to 17.5 per thousand (Connecticut). The COVID-19 mortality rate in people <65 years old during the period of fatalities from the epidemic was equivalent to the mortality rate from driving between 4 and 82 miles per day for 13 countries and 5 states, and was higher (equivalent to the mortality rate from driving 106-483 miles per day) for 8 other states and the UK. People <65 years old without underlying predisposing conditions accounted for only 0.7-3.6% of all COVID-19 deaths in France, Italy, Netherlands, Sweden, Georgia, and New York City and 17.7% in Mexico.\r\n\r\nPeople <65 years old have very small risks of COVID-19 death even in pandemic epicenters and deaths for people <65 years without underlying predisposing conditions are remarkably uncommon. Strategies focusing specifically on protecting high-risk elderly individuals should be considered in managing the pandemic.", "doi": "10.1016/j.envres.2020.109890", "pmid": "32846654", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0013-9351(20)30785-4"}, {"db": "pmc", "key": "PMC7327471"}, {"db": "URL", "key": "https://ars.els-cdn.com/content/image/1-s2.0-S0013935120307854-mmc2.pdf", "description": "Number of COVID-19 deaths contributed by specific age group and population characteristics for 14 countries and 13 US states"}], "notes": [], "created": "2020-11-22T09:56:51.290Z", "modified": "2021-02-26T08:46:59.789Z"}, {"entity": "publication", "iuid": "536b4d0da2254331a79a3bf4d5693abc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/536b4d0da2254331a79a3bf4d5693abc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/536b4d0da2254331a79a3bf4d5693abc"}}, "title": "Per capita death and infection rates should be avoided in international comparisons.", "authors": [{"family": "Silva", "given": "W T A F", "initials": "WTAF"}], "type": "letter", "published": "2020-09-00", "journal": {"title": "Public Health", "issn": "1476-5616", "volume": "186", "issue": null, "pages": "18-19", "issn-l": null}, "abstract": null, "doi": "10.1016/j.puhe.2020.06.038", "pmid": "32750504", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0033-3506(20)30276-6"}, {"db": "pmc", "key": "PMC7395585"}], "notes": [], "created": "2020-12-07T15:48:12.388Z", "modified": "2020-12-07T15:48:12.410Z"}, {"entity": "publication", "iuid": "c1f02d70a3814642add901ea579ed297", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1f02d70a3814642add901ea579ed297.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1f02d70a3814642add901ea579ed297"}}, "title": "Peer Review Week 2020: Eurosurveillance thanks all COVID-19 reviewers for their amazing work.", "authors": [{"family": "Eurosurveillance editorial team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "38", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.38.2009242", "pmid": "32975183", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7533617"}], "notes": [], "created": "2020-12-03T14:32:25.284Z", "modified": "2020-12-03T14:32:25.294Z"}, {"entity": "publication", "iuid": "5a93a8b03dbb42fba1d041a2c4b25fcc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5a93a8b03dbb42fba1d041a2c4b25fcc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5a93a8b03dbb42fba1d041a2c4b25fcc"}}, "title": "Management of the emergency response to the SARS-CoV-2 (COVID-19) outbreak in Stockholm, Sweden, and winter preparations.", "authors": [{"family": "Ohrling", "given": "Mikael", "initials": "M"}, {"family": "\u00d8vretveit", "given": "John", "initials": "J"}, {"family": "Lockowandt", "given": "Ulf", "initials": "U"}, {"family": "Brommels", "given": "Mats", "initials": "M"}, {"family": "Sparring", "given": "Vibeke", "initials": "V"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "J Prim Health Care", "issn": "1172-6156", "volume": "12", "issue": "3", "pages": "207-214", "issn-l": null}, "abstract": "INTRODUCTION Sweden is unique in adopting a 'no-lockdown' public health approach to the SARS-CoV-2 (COVID-19) outbreak. There were fears that health services would not be able to care for high numbers of COVID-19 patients. AIM To describe and review the emergency response of a public primary and community health-care organisation in Stockholm, Sweden, to the demand for care for COVID-19 and non-COVID-19 patients during March-July 2020, and summarise preparations for the months to follow. METHODS This was a rapid implementation action research case study, which also draws on one author's experience as Chief Executive Officer and other members' experience in an emergency management group. RESULTS Sweden experienced similar mortality per million population to the UK, despite the different public health strategy used to address the COVID-19 outbreak. The Stockholm-integrated public primary and community health-care service, serving a population of 2.3 million, made many changes quickly. One change included coordinating non-acute private health-care services, following the local government emergency directive to do so. DISCUSSION It is possible that the fast and effective response by management and services in primary and community health care reduced infection and hospital demand, which contributed to a lower mortality than otherwise expected. The actions and preparations described for Stockholm's response may provide ideas for other health-care systems. The partnership research approach between the Karolinska Medical University and the Region Stockholm health-care system used in this project shows that rapid research methods have advantages for both partners in an emergency situation.", "doi": "10.1071/HC20082", "pmid": "32988442", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "HC20082"}], "notes": [], "created": "2020-11-27T12:40:02.016Z", "modified": "2020-11-27T12:40:02.043Z"}, {"entity": "publication", "iuid": "f6a0171db3c84f31880fcd505070a25c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6a0171db3c84f31880fcd505070a25c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6a0171db3c84f31880fcd505070a25c"}}, "title": "Investigating mediated effects of fear of COVID-19 and COVID-19 misunderstanding in the association between problematic social media use, psychological distress, and insomnia.", "authors": [{"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Internet Interv", "issn": "2214-7829", "volume": "21", "issue": null, "pages": "100345", "issn-l": "2214-7829"}, "abstract": "Due to the serious situation of the novel coronavirus disease 2019 (COVID-19) worldwide, many countries have implemented policies to minimize the spread of COVID-19 infection. However, some of these policies prevent people from physical contact. Consequently, many individuals may rely on social media to obtain information concerning COVID-19. Unfortunately, social media use (especially problematic social media use) may give rise to psychological distress. Therefore, this study thus examined potential psychopathology to explain the association between problematic social media use, psychological distress, and insomnia.\n\nUtilizing an online survey, a sample of Iranian young adults (n = 1078 with 628 males; mean age = 26.24 years [SD \u00b1 7.41]) completed questions and psychometric scales concerning psychological distress, insomnia, problematic social media use, fear of COVID-19, and COVID-19 misunderstanding.\n\nProblematic social media use was significantly associated with psychological distress both directly and indirectly. The indirect effects were through fear of COVID-19 (unstandardized coefficient [B] = 0.177; Bootstrapping SE = 0.026) and COVID-19 misunderstanding (B = 0.060; Bootstrapping SE = 0.014). Problematic social media use was significantly associated with insomnia both directly and indirectly. The indirect effect was through fear of COVID-19 (B = 0.062; Bootstrapping SE = 0.019) but not COVID-19 misunderstanding (B = 0.012; Bootstrapping SE = 0.014).\n\nDue to the pressure of the COVID-19 outbreak, individuals are highly likely to develop psychological distress and insomnia. Apart from developing appropriate health policies to minimize the spread of COVID-19 infection, healthcare providers should design appropriate online campaigns to eliminate people's fear of COVID-19 and to diminish misunderstanding concerning COVID-19.", "doi": "10.1016/j.invent.2020.100345", "pmid": "32868992", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2214-7829(20)30111-1"}, {"db": "pii", "key": "100345"}, {"db": "pmc", "key": "PMC7449889"}], "notes": [], "created": "2020-12-07T07:49:52.173Z", "modified": "2021-02-26T08:45:48.868Z"}, {"entity": "publication", "iuid": "c4ef5f067c2a45bfba4aecc0e83e2ae4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c4ef5f067c2a45bfba4aecc0e83e2ae4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c4ef5f067c2a45bfba4aecc0e83e2ae4"}}, "title": "International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells: considerations for potential therapeutic agents to suppress coronavirus disease-19.", "authors": [{"family": "B\u00f6rger", "given": "Verena", "initials": "V"}, {"family": "Weiss", "given": "Daniel J", "initials": "DJ"}, {"family": "Anderson", "given": "Johnathon D", "initials": "JD"}, {"family": "Borr\u00e0s", "given": "Francesc E", "initials": "FE"}, {"family": "Bussolati", "given": "Benedetta", "initials": "B"}, {"family": "Carter", "given": "David R F", "initials": "DRF"}, {"family": "Dominici", "given": "Massimo", "initials": "M"}, {"family": "Falc\u00f3n-P\u00e9rez", "given": "Juan M", "initials": "JM"}, {"family": "Gimona", "given": "Mario", "initials": "M"}, {"family": "Hill", "given": "Andrew F", "initials": "AF"}, {"family": "Hoffman", "given": "Andrew M", "initials": "AM"}, {"family": "de Kleijn", "given": "Dominique", "initials": "D"}, {"family": "Levine", "given": "Bruce L", "initials": "BL"}, {"family": "Lim", "given": "Rebecca", "initials": "R"}, {"family": "L\u00f6tvall", "given": "Jan", "initials": "J"}, {"family": "Mitsialis", "given": "S Alex", "initials": "SA"}, {"family": "Mongui\u00f3-Tortajada", "given": "Marta", "initials": "M"}, {"family": "Muraca", "given": "Maurizio", "initials": "M"}, {"family": "Nieuwland", "given": "Rienk", "initials": "R"}, {"family": "Nowocin", "given": "Anna", "initials": "A"}, {"family": "O'Driscoll", "given": "Lorraine", "initials": "L"}, {"family": "Ortiz", "given": "Luis A", "initials": "LA"}, {"family": "Phinney", "given": "Donald G", "initials": "DG"}, {"family": "Reischl", "given": "Ilona", "initials": "I"}, {"family": "Rohde", "given": "Eva", "initials": "E"}, {"family": "Sanzenbacher", "given": "Ralf", "initials": "R"}, {"family": "Th\u00e9ry", "given": "Clotilde", "initials": "C"}, {"family": "Toh", "given": "Wei Seong", "initials": "WS"}, {"family": "Witwer", "given": "Kenneth W", "initials": "KW"}, {"family": "Lim", "given": "Sai Kiang", "initials": "SK"}, {"family": "Giebel", "given": "Bernd", "initials": "B"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Cytotherapy", "issn": "1477-2566", "issn-l": "1465-3249", "volume": "22", "issue": "9", "pages": "482-485"}, "abstract": "The International Society for Cellular and Gene Therapies (ISCT) and the International Society for Extracellular Vesicles (ISEV) recognize the potential of extracellular vesicles (EVs, including exosomes) from mesenchymal stromal cells (MSCs) and possibly other cell sources as treatments for COVID-19. Research and trials in this area are encouraged. However, ISEV and ISCT do not currently endorse the use of EVs or exosomes for any purpose in COVID-19, including but not limited to reducing cytokine storm, exerting regenerative effects or delivering drugs, pending the generation of appropriate manufacturing and quality control provisions, pre-clinical safety and efficacy data, rational clinical trial design and proper regulatory oversight.", "doi": "10.1016/j.jcyt.2020.05.002", "pmid": "32425691", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1465-3249(20)30662-9"}, {"db": "pmc", "key": "PMC7229942"}], "notes": [], "created": "2020-12-09T11:42:20.533Z", "modified": "2020-12-09T11:43:02.272Z"}, {"entity": "publication", "iuid": "f5b6380c3bbe4d49872fd22bd68b6c42", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f5b6380c3bbe4d49872fd22bd68b6c42.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f5b6380c3bbe4d49872fd22bd68b6c42"}}, "title": "Impact on hospital admission of ST-elevation myocardial infarction patients during coronavirus disease 2019 pandemic in an Italian Hospital.", "authors": [{"family": "Di Liberto", "given": "Ilenia Alessandra", "initials": "IA"}, {"family": "Pilato", "given": "Gerlando", "initials": "G"}, {"family": "Geraci", "given": "Salvatore", "initials": "S"}, {"family": "Milazzo", "given": "Diego", "initials": "D"}, {"family": "Vaccaro", "given": "Giovanni", "initials": "G"}, {"family": "Buccheri", "given": "Sergio", "initials": "S"}, {"family": "Caramanno", "given": "Giuseppe", "initials": "G"}], "type": "comparative study", "published": "2020-09-00", "journal": {"title": "J Cardiovasc Med (Hagerstown)", "issn": "1558-2035", "volume": "21", "issue": "9", "pages": "722-724", "issn-l": null}, "abstract": null, "doi": "10.2459/JCM.0000000000001053", "pmid": "32658006", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "01244665-202009000-00019"}], "notes": [], "created": "2020-12-08T14:13:31.185Z", "modified": "2022-11-10T06:47:26.083Z"}, {"entity": "publication", "iuid": "5bd4ea9f76bc4a0e9ebb682ab140f3c2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5bd4ea9f76bc4a0e9ebb682ab140f3c2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5bd4ea9f76bc4a0e9ebb682ab140f3c2"}}, "title": "Impact of COVID-19 on Pediatric Asthma: Practice Adjustments and Disease Burden.", "authors": [{"family": "Papadopoulos", "given": "Nikolaos G", "initials": "NG"}, {"family": "Custovic", "given": "Adnan", "initials": "A"}, {"family": "Deschildre", "given": "Antoine", "initials": "A"}, {"family": "Mathioudakis", "given": "Alexander G", "initials": "AG"}, {"family": "Phipatanakul", "given": "Wanda", "initials": "W"}, {"family": "Wong", "given": "Gary", "initials": "G"}, {"family": "Xepapadaki", "given": "Paraskevi", "initials": "P"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Bacharier", "given": "Leonard", "initials": "L"}, {"family": "Bonini", "given": "Matteo", "initials": "M"}, {"family": "Castro-Rodriguez", "given": "Jose A", "initials": "JA"}, {"family": "Chen", "given": "Zhimin", "initials": "Z"}, {"family": "Craig", "given": "Timothy", "initials": "T"}, {"family": "Ducharme", "given": "Francine M", "initials": "FM"}, {"family": "El-Sayed", "given": "Zeinab Awad", "initials": "ZA"}, {"family": "Feleszko", "given": "Wojciech", "initials": "W"}, {"family": "Fiocchi", "given": "Alessandro", "initials": "A"}, {"family": "Garcia-Marcos", "given": "Luis", "initials": "L"}, {"family": "Gern", "given": "James E", "initials": "JE"}, {"family": "Goh", "given": "Anne", "initials": "A"}, {"family": "G\u00f3mez", "given": "Ren\u00e9 Maximiliano", "initials": "RM"}, {"family": "Hamelmann", "given": "Eckard H", "initials": "EH"}, {"family": "Hedlin", "given": "Gunilla", "initials": "G"}, {"family": "Hossny", "given": "Elham M", "initials": "EM"}, {"family": "Jartti", "given": "Tuomas", "initials": "T"}, {"family": "Kalayci", "given": "Omer", "initials": "O"}, {"family": "Kaplan", "given": "Alan", "initials": "A"}, {"family": "Konradsen", "given": "Jon", "initials": "J"}, {"family": "Kuna", "given": "Piotr", "initials": "P"}, {"family": "Lau", "given": "Susanne", "initials": "S"}, {"family": "Le Souef", "given": "Peter", "initials": "P"}, {"family": "Lemanske", "given": "Robert F", "initials": "RF"}, {"family": "M\u00e4kel\u00e4", "given": "Mika J", "initials": "MJ"}, {"family": "Morais-Almeida", "given": "M\u00e1rio", "initials": "M"}, {"family": "Murray", "given": "Clare", "initials": "C"}, {"family": "Nagaraju", "given": "Karthik", "initials": "K"}, {"family": "Namazova-Baranova", "given": "Leyla", "initials": "L"}, {"family": "Garcia", "given": "Antonio Nieto", "initials": "AN"}, {"family": "Yusuf", "given": "Osman M", "initials": "OM"}, {"family": "Pitrez", "given": "Paulo M C", "initials": "PMC"}, {"family": "Pohunek", "given": "Petr", "initials": "P"}, {"family": "Pozo Beltr\u00e1n", "given": "Cesar Fireth", "initials": "CF"}, {"family": "Roberts", "given": "Graham C", "initials": "GC"}, {"family": "Valiulis", "given": "Arunas", "initials": "A"}, {"family": "Zar", "given": "Heather J", "initials": "HJ"}, {"family": "Pediatric Asthma in Real Life Collaborators", "given": "", "initials": ""}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "J Allergy Clin Immunol Pract", "issn": "2213-2201", "volume": "8", "issue": "8", "pages": "2592-2599.e3", "issn-l": null}, "abstract": "It is unclear whether asthma may affect susceptibility or severity of coronavirus disease 2019 (COVID-19) in children and how pediatric asthma services worldwide have responded to the pandemic.\n\nTo describe the impact of the COVID-19 pandemic on pediatric asthma services and on disease burden in their patients.\n\nAn online survey was sent to members of the Pediatric Asthma in Real Life think tank and the World Allergy Organization Pediatric Asthma Committee. It included questions on service provision, disease burden, and the clinical course of confirmed cases of COVID-19 infection among children with asthma.\n\nNinety-one respondents, caring for an estimated population of more than 133,000 children with asthma, completed the survey. COVID-19 significantly impacted pediatric asthma services: 39% ceased physical appointments, 47% stopped accepting new patients, and 75% limited patients' visits. Consultations were almost halved to a median of 20 (interquartile range, 10-25) patients per week. Virtual clinics and helplines were launched in most centers. Better than expected disease control was reported in 20% (10%-40%) of patients, whereas control was negatively affected in only 10% (7.5%-12.5%). Adherence also appeared to increase. Only 15 confirmed cases of COVID-19 were reported among the population; the estimated incidence is not apparently different from the reports of general pediatric cohorts.\n\nChildren with asthma do not appear to be disproportionately affected by COVID-19. Outcomes may even have improved, possibly through increased adherence and/or reduced exposures. Clinical services have rapidly responded to the pandemic by limiting and replacing physical appointments with virtual encounters.", "doi": "10.1016/j.jaip.2020.06.001", "pmid": "32561497", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-2198(20)30599-7"}, {"db": "pmc", "key": "PMC7297686"}], "notes": [], "created": "2020-12-09T07:42:32.450Z", "modified": "2021-02-26T08:46:13.142Z"}, {"entity": "publication", "iuid": "4bf14407a4204ed48d96d76ba237a0ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4bf14407a4204ed48d96d76ba237a0ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4bf14407a4204ed48d96d76ba237a0ca"}}, "title": "How can airborne transmission of COVID-19 indoors be minimised?", "authors": [{"family": "Morawska", "given": "Lidia", "initials": "L"}, {"family": "Tang", "given": "Julian W", "initials": "JW"}, {"family": "Bahnfleth", "given": "William", "initials": "W"}, {"family": "Bluyssen", "given": "Philomena M", "initials": "PM"}, {"family": "Boerstra", "given": "Atze", "initials": "A"}, {"family": "Buonanno", "given": "Giorgio", "initials": "G"}, {"family": "Cao", "given": "Junji", "initials": "J"}, {"family": "Dancer", "given": "Stephanie", "initials": "S"}, {"family": "Floto", "given": "Andres", "initials": "A"}, {"family": "Franchimon", "given": "Francesco", "initials": "F"}, {"family": "Haworth", "given": "Charles", "initials": "C"}, {"family": "Hogeling", "given": "Jaap", "initials": "J"}, {"family": "Isaxon", "given": "Christina", "initials": "C"}, {"family": "Jimenez", "given": "Jose L", "initials": "JL"}, {"family": "Kurnitski", "given": "Jarek", "initials": "J"}, {"family": "Li", "given": "Yuguo", "initials": "Y"}, {"family": "Loomans", "given": "Marcel", "initials": "M"}, {"family": "Marks", "given": "Guy", "initials": "G"}, {"family": "Marr", "given": "Linsey C", "initials": "LC"}, {"family": "Mazzarella", "given": "Livio", "initials": "L"}, {"family": "Melikov", "given": "Arsen Krikor", "initials": "AK"}, {"family": "Miller", "given": "Shelly", "initials": "S"}, {"family": "Milton", "given": "Donald K", "initials": "DK"}, {"family": "Nazaroff", "given": "William", "initials": "W"}, {"family": "Nielsen", "given": "Peter V", "initials": "PV"}, {"family": "Noakes", "given": "Catherine", "initials": "C"}, {"family": "Peccia", "given": "Jordan", "initials": "J"}, {"family": "Querol", "given": "Xavier", "initials": "X"}, {"family": "Sekhar", "given": "Chandra", "initials": "C"}, {"family": "Sepp\u00e4nen", "given": "Olli", "initials": "O"}, {"family": "Tanabe", "given": "Shin-Ichi", "initials": "SI"}, {"family": "Tellier", "given": "Raymond", "initials": "R"}, {"family": "Tham", "given": "Kwok Wai", "initials": "KW"}, {"family": "Wargocki", "given": "Pawel", "initials": "P"}, {"family": "Wierzbicka", "given": "Aneta", "initials": "A"}, {"family": "Yao", "given": "Maosheng", "initials": "M"}], "type": "letter", "published": "2020-09-00", "journal": {"title": "Environ Int", "issn": "1873-6750", "volume": "142", "issue": null, "pages": "105832", "issn-l": "0160-4120"}, "abstract": "During the rapid rise in COVID-19 illnesses and deaths globally, and notwithstanding recommended precautions, questions are voiced about routes of transmission for this pandemic disease. Inhaling small airborne droplets is probable as a third route of infection, in addition to more widely recognized transmission via larger respiratory droplets and direct contact with infected people or contaminated surfaces. While uncertainties remain regarding the relative contributions of the different transmission pathways, we argue that existing evidence is sufficiently strong to warrant engineering controls targeting airborne transmission as part of an overall strategy to limit infection risk indoors. Appropriate building engineering controls include sufficient and effective ventilation, possibly enhanced by particle filtration and air disinfection, avoiding air recirculation and avoiding overcrowding. Often, such measures can be easily implemented and without much cost, but if only they are recognised as significant in contributing to infection control goals. We believe that the use of engineering controls in public buildings, including hospitals, shops, offices, schools, kindergartens, libraries, restaurants, cruise ships, elevators, conference rooms or public transport, in parallel with effective application of other controls (including isolation and quarantine, social distancing and hand hygiene), would be an additional important measure globally to reduce the likelihood of transmission and thereby protect healthcare workers, patients and the general public.", "doi": "10.1016/j.envint.2020.105832", "pmid": "32521345", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0160-4120(20)31787-6"}, {"db": "pmc", "key": "PMC7250761"}], "notes": [], "created": "2020-12-09T10:12:52.339Z", "modified": "2020-12-09T10:12:52.349Z"}, {"entity": "publication", "iuid": "313df89a1c90406e9b8f582c33b51de2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/313df89a1c90406e9b8f582c33b51de2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/313df89a1c90406e9b8f582c33b51de2"}}, "title": "Heparin \u2013 An old drug with multiple potential targets in Covid\u201019 therapy", "authors": [{"family": "Lindahl", "given": "Ulf", "initials": "U"}, {"family": "Li", "given": "Jin\u2010Ping", "initials": "J"}], "type": "journal-article", "published": "2020-09-00", "journal": {"title": "J Thromb Haemost", "issn": "1538-7836", "issn-l": null, "volume": "18", "issue": "9", "pages": "2422-2424"}, "abstract": null, "doi": "10.1111/jth.14898", "pmid": "32426897", "labels": {"Type: Journal article": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC7276884"}], "notes": [], "created": "2020-12-04T08:52:17.388Z", "modified": "2021-12-06T13:16:11.752Z"}, {"entity": "publication", "iuid": "fc005ee705ce4020a7b935bd77738338", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc005ee705ce4020a7b935bd77738338.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc005ee705ce4020a7b935bd77738338"}}, "title": "Editorial: Fifty Campbell systematic reviews relevant to the policy response to COVID-19.", "authors": [{"family": "Board", "given": "Campbell Editorial", "initials": "CE"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Campbell Syst Rev", "issn": "1891-1803", "volume": "16", "issue": "3", "pages": "e1107", "issn-l": null}, "abstract": null, "doi": "10.1002/cl2.1107", "pmid": "34234882", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "CL21107"}, {"db": "pmc", "key": "PMC7435573"}], "notes": [], "created": "2021-08-06T08:24:53.424Z", "modified": "2021-08-06T08:25:44.337Z"}, {"entity": "publication", "iuid": "7df03080a93f4616927e9fdeb1a5576c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7df03080a93f4616927e9fdeb1a5576c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7df03080a93f4616927e9fdeb1a5576c"}}, "title": "Does prolonged propofol sedation of mechanically ventilated COVID-19 patients contribute to critical illness myopathy?", "authors": [{"family": "L\u00f6nnqvist", "given": "Per-Arne", "initials": "PA"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "Karlsson", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Wiklund", "given": "Lars", "initials": "L"}, {"family": "H\u00f6glund", "given": "Anna-Stina", "initials": "AS"}, {"family": "Larsson", "given": "Lars", "initials": "L"}], "type": "letter", "published": "2020-09-00", "journal": {"title": "Br J Anaesth", "issn": "1471-6771", "volume": "125", "issue": "3", "pages": "e334-e336", "issn-l": "0007-0912"}, "abstract": null, "doi": "10.1016/j.bja.2020.05.056", "pmid": "32600801", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0007-0912(20)30440-2"}, {"db": "pmc", "key": "PMC7284264"}], "notes": [], "created": "2020-11-22T08:45:29.899Z", "modified": "2021-02-26T08:45:48.396Z"}, {"entity": "publication", "iuid": "e973ffa8e5bb4fbeae8c51c1cf412a37", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e973ffa8e5bb4fbeae8c51c1cf412a37.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e973ffa8e5bb4fbeae8c51c1cf412a37"}}, "title": "Diagnostic performance of initial blood urea nitrogen combined with D-dimer levels for predicting in-hospital mortality in COVID-19 patients.", "authors": [{"family": "Cheng", "given": "Anying", "initials": "A"}, {"family": "Hu", "given": "Liu", "initials": "L"}, {"family": "Wang", "given": "Yiru", "initials": "Y"}, {"family": "Huang", "given": "Luyan", "initials": "L"}, {"family": "Zhao", "given": "Lingxi", "initials": "L"}, {"family": "Zhang", "given": "Congcong", "initials": "C"}, {"family": "Liu", "given": "Xiyue", "initials": "X"}, {"family": "Xu", "given": "Ranran", "initials": "R"}, {"family": "Liu", "given": "Feng", "initials": "F"}, {"family": "Li", "given": "Jinping", "initials": "J"}, {"family": "Ye", "given": "Dawei", "initials": "D"}, {"family": "Wang", "given": "Tao", "initials": "T"}, {"family": "Lv", "given": "Yongman", "initials": "Y"}, {"family": "Liu", "given": "Qingquan", "initials": "Q"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Int J Antimicrob Agents", "issn": "1872-7913", "volume": "56", "issue": "3", "pages": "106110", "issn-l": null}, "abstract": "The crude mortality rate in critical pneumonia cases with coronavirus disease 2019 (COVID-19) reaches 49%. This study aimed to test whether levels of blood urea nitrogen (BUN) in combination with D-dimer were predictors of in-hospital mortality in COVID-19 patients. The clinical characteristics of 305 COVID-19 patients were analysed and were compared between the survivor and non-survivor groups. Of the 305 patients, 85 (27.9%) died and 220 (72.1%) were discharged from hospital. Compared with discharged cases, non-survivor cases were older and their BUN and D-dimer levels were significantly higher (P < 0.0001). Least absolute shrinkage and selection operator (LASSO) and multivariable Cox regression analyses identified BUN and D-dimer levels as independent risk factors for poor prognosis. Kaplan-Meier analysis showed that elevated levels of BUN and D-dimer were associated with increased mortality (log-rank, P < 0.0001). The area under the curve for BUN combined with D-dimer was 0.94 (95% CI 0.90-0.97), with a sensitivity of 85% and specificity of 91%. Based on BUN and D-dimer levels on admission, a nomogram model was developed that showed good discrimination, with a concordance index of 0.94. Together, initial BUN and D-dimer levels were associated with mortality in COVID-19 patients. The combination of BUN \u2265 4.6 mmol/L and D-dimer \u2265 0.845 \u03bcg/mL appears to identify patients at high risk of in-hospital mortality, therefore it may prove to be a powerful risk assessment tool for severe COVID-19 patients.", "doi": "10.1016/j.ijantimicag.2020.106110", "pmid": "32712332", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0924-8579(20)30293-4"}, {"db": "pmc", "key": "PMC7377803"}], "notes": [], "created": "2020-12-07T16:15:03.755Z", "modified": "2021-02-26T08:45:48.829Z"}, {"entity": "publication", "iuid": "da6866a15f904121ace0557c7923f7b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/da6866a15f904121ace0557c7923f7b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/da6866a15f904121ace0557c7923f7b9"}}, "title": "Developing thinking around mental health science: the example of intrusive, emotional mental imagery after psychological trauma.", "authors": [{"family": "Singh", "given": "Laura", "initials": "L"}, {"family": "Espinosa", "given": "Lisa", "initials": "L"}, {"family": "Ji", "given": "Julie L", "initials": "JL"}, {"family": "Moulds", "given": "Michelle L", "initials": "ML"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Cogn Neuropsychiatry", "issn": "1464-0619", "volume": "25", "issue": "5", "pages": "348-363", "issn-l": "1354-6805"}, "abstract": "One route to advancing psychological treatments is to harness mental health science, a multidisciplinary approach including individuals with lived experience and end users (e.g., Holmes, E. A., Craske, M. G., & Graybiel, A. M. (2014). Psychological treatments: A call for mental-health science. Nature, 511(7509), 287-289. doi:10.1038/511287a). While early days, we here illustrate a line of research explored by our group-intrusive imagery-based memories after trauma.\n\nWe illustrate three possible approaches through which mental health science may stimulate thinking around psychological treatment innovation. First, focusing on single/specific target symptoms rather than full, multifaceted psychiatric diagnoses (e.g., intrusive trauma memories rather than all of posttraumatic stress disorder). Second, investigating mechanisms that can be modified in treatment (treatment mechanisms), rather than those which cannot (e.g., processes only linked to aetiology). Finally, exploring novel ways of delivering psychological treatment (peer-/self-administration), given the prevalence of mental health problems globally, and the corresponding need for effective interventions that can be delivered at scale and remotely for example at times of crisis (e.g., current COVID-19 pandemic).\n\nThese three approaches suggest options for potential innovative avenues through which mental health science may be harnessed to recouple basic and applied research and transform treatment development.", "doi": "10.1080/13546805.2020.1804845", "pmid": "32847486", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-22T09:55:45.251Z", "modified": "2020-11-30T08:36:36.440Z"}, {"entity": "publication", "iuid": "d9bdeca3f991438e9dec081348aa9da9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d9bdeca3f991438e9dec081348aa9da9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d9bdeca3f991438e9dec081348aa9da9"}}, "title": "Coagulation disorder in COVID-19.", "authors": [{"family": "Kander", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Lancet Haematol", "issn": "2352-3026", "volume": "7", "issue": "9", "pages": "e630-e632", "issn-l": null}, "abstract": null, "doi": "10.1016/S2352-3026(20)30218-0", "pmid": "32659213", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2352-3026(20)30218-0"}, {"db": "pmc", "key": "PMC7351400"}], "notes": [], "created": "2020-12-08T14:11:45.590Z", "modified": "2020-12-08T14:11:45.611Z"}, {"entity": "publication", "iuid": "c232619d7e704e339f0fd02748324289", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c232619d7e704e339f0fd02748324289.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c232619d7e704e339f0fd02748324289"}}, "title": "Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke: The Global COVID-19 Stroke Registry.", "authors": [{"family": "Ntaios", "given": "George", "initials": "G"}, {"family": "Michel", "given": "Patrik", "initials": "P"}, {"family": "Georgiopoulos", "given": "Georgios", "initials": "G"}, {"family": "Guo", "given": "Yutao", "initials": "Y"}, {"family": "Li", "given": "Wencheng", "initials": "W"}, {"family": "Xiong", "given": "Jing", "initials": "J"}, {"family": "Calleja", "given": "Patricia", "initials": "P"}, {"family": "Ostos", "given": "Fernando", "initials": "F"}, {"family": "Gonz\u00e1lez-Ortega", "given": "Guillermo", "initials": "G"}, {"family": "Fuentes", "given": "Blanca", "initials": "B"}, {"family": "Alonso de Leci\u00f1ana", "given": "Mar\u00eda", "initials": "M"}, {"family": "D\u00edez-Tejedor", "given": "Exuperio", "initials": "E"}, {"family": "Garc\u00eda-Madrona", "given": "Sebastian", "initials": "S"}, {"family": "Masjuan", "given": "Jaime", "initials": "J"}, {"family": "DeFelipe", "given": "Alicia", "initials": "A"}, {"family": "Turc", "given": "Guillaume", "initials": "G"}, {"family": "Gon\u00e7alves", "given": "Bruno", "initials": "B"}, {"family": "Domigo", "given": "Valerie", "initials": "V"}, {"family": "Dan", "given": "Gheorghe-Andrei", "initials": "GA"}, {"family": "Vezeteu", "given": "Roxana", "initials": "R"}, {"family": "Christensen", "given": "Hanne", "initials": "H"}, {"family": "Christensen", "given": "Louisa Marguerite", "initials": "LM"}, {"family": "Meden", "given": "Per", "initials": "P"}, {"family": "Hajdarevic", "given": "Lejla", "initials": "L"}, {"family": "Rodriguez-Lopez", "given": "Angela", "initials": "A"}, {"family": "D\u00edaz-Otero", "given": "Fernando", "initials": "F"}, {"family": "Garc\u00eda-Pastor", "given": "Andr\u00e9s", "initials": "A"}, {"family": "Gil-Nu\u00f1ez", "given": "Antonio", "initials": "A"}, {"family": "Maslias", "given": "Errikos", "initials": "E"}, {"family": "Strambo", "given": "Davide", "initials": "D"}, {"family": "Werring", "given": "David J", "initials": "DJ"}, {"family": "Chandratheva", "given": "Arvind", "initials": "A"}, {"family": "Benjamin", "given": "Laura", "initials": "L"}, {"family": "Simister", "given": "Robert", "initials": "R"}, {"family": "Perry", "given": "Richard", "initials": "R"}, {"family": "Beyrouti", "given": "Rahma", "initials": "R"}, {"family": "Jabbour", "given": "Pascal", "initials": "P"}, {"family": "Sweid", "given": "Ahmad", "initials": "A"}, {"family": "Tjoumakaris", "given": "Stavropoula", "initials": "S"}, {"family": "Cuadrado-Godia", "given": "Elisa", "initials": "E"}, {"family": "Campello", "given": "Ana Rodr\u00edguez", "initials": "AR"}, {"family": "Roquer", "given": "Jaume", "initials": "J"}, {"family": "Moreira", "given": "Tiago", "initials": "T"}, {"family": "Mazya", "given": "Michael V", "initials": "MV"}, {"family": "Bandini", "given": "Fabio", "initials": "F"}, {"family": "Matz", "given": "Karl", "initials": "K"}, {"family": "Iversen", "given": "Helle K", "initials": "HK"}, {"family": "Gonz\u00e1lez-Duarte", "given": "Alejandra", "initials": "A"}, {"family": "Tiu", "given": "Cristina", "initials": "C"}, {"family": "Ferrari", "given": "Julia", "initials": "J"}, {"family": "Vosko", "given": "Milan R", "initials": "MR"}, {"family": "Salzer", "given": "Helmut J F", "initials": "HJF"}, {"family": "Lamprecht", "given": "Bernd", "initials": "B"}, {"family": "D\u00fcnser", "given": "Martin W", "initials": "MW"}, {"family": "Cereda", "given": "Carlo W", "initials": "CW"}, {"family": "Quintero", "given": "\u00c1ngel Basilio Corredor", "initials": "\u00c1BC"}, {"family": "Korompoki", "given": "Eleni", "initials": "E"}, {"family": "Soriano-Navarro", "given": "Eduardo", "initials": "E"}, {"family": "Soto-Ram\u00edrez", "given": "Luis Enrique", "initials": "LE"}, {"family": "Casta\u00f1eda-M\u00e9ndez", "given": "Paulo F", "initials": "PF"}, {"family": "Bay-Sansores", "given": "Daniela", "initials": "D"}, {"family": "Arauz", "given": "Antonio", "initials": "A"}, {"family": "Cano-Nigenda", "given": "Vanessa", "initials": "V"}, {"family": "Kristoffersen", "given": "Espen Saxhaug", "initials": "ES"}, {"family": "Tiainen", "given": "Marjaana", "initials": "M"}, {"family": "Strbian", "given": "Daniel", "initials": "D"}, {"family": "Putaala", "given": "Jukka", "initials": "J"}, {"family": "Lip", "given": "Gregory Y H", "initials": "GYH"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Stroke", "issn": "1524-4628", "volume": "51", "issue": "9", "pages": "e254-e258", "issn-l": null}, "abstract": "Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that severe strokes are typically associated with poor prognosis and can be very efficiently treated with recanalization techniques, confirmation of this putative association is urgently warranted in a large representative patient cohort to alert stroke clinicians, and inform pre- and in-hospital acute stroke patient pathways. We pooled all consecutive patients hospitalized with laboratory-confirmed COVID-19 and acute ischemic stroke in 28 sites from 16 countries. To assess whether stroke severity and outcomes (assessed at discharge or at the latest assessment for those patients still hospitalized) in patients with acute ischemic stroke are different between patients with COVID-19 and non-COVID-19, we performed 1:1 propensity score matching analyses of our COVID-19 patients with non-COVID-19 patients registered in the Acute Stroke Registry and Analysis of Lausanne Registry between 2003 and 2019. Between January 27, 2020, and May 19, 2020, 174 patients (median age 71.2 years; 37.9% females) with COVID-19 and acute ischemic stroke were hospitalized (median of 12 patients per site). The median National Institutes of Health Stroke Scale was 10 (interquartile range [IQR], 4-18). In the 1:1 matched sample of 336 patients with COVID-19 and non-COVID-19, the median National Institutes of Health Stroke Scale was higher in patients with COVID-19 (10 [IQR, 4-18] versus 6 [IQR, 3-14]), P=0.03; (odds ratio, 1.69 [95% CI, 1.08-2.65] for higher National Institutes of Health Stroke Scale score). There were 48 (27.6%) deaths, of which 22 were attributed to COVID-19 and 26 to stroke. Among 96 survivors with available information about disability status, 49 (51%) had severe disability at discharge. In the propensity score-matched population (n=330), patients with COVID-19 had higher risk for severe disability (median mRS 4 [IQR, 2-6] versus 2 [IQR, 1-4], P<0.001) and death (odds ratio, 4.3 [95% CI, 2.22-8.30]) compared with patients without COVID-19. Our findings suggest that COVID-19 associated ischemic strokes are more severe with worse functional outcome and higher mortality than non-COVID-19 ischemic strokes.", "doi": "10.1161/STROKEAHA.120.031208", "pmid": "32787707", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7359900"}], "notes": [], "created": "2020-12-07T13:28:17.725Z", "modified": "2020-12-07T13:28:17.748Z"}, {"entity": "publication", "iuid": "cd3b5e14785c493a88046a386f265e86", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd3b5e14785c493a88046a386f265e86.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd3b5e14785c493a88046a386f265e86"}}, "title": "COVID-19: guidance on palliative care from a European Respiratory Society international task force.", "authors": [{"family": "Janssen", "given": "Daisy J A", "initials": "DJA"}, {"family": "Ekstr\u00f6m", "given": "Magnus", "initials": "M"}, {"family": "Currow", "given": "David C", "initials": "DC"}, {"family": "Johnson", "given": "Miriam J", "initials": "MJ"}, {"family": "Maddocks", "given": "Matthew", "initials": "M"}, {"family": "Simonds", "given": "Anita K", "initials": "AK"}, {"family": "Tonia", "given": "Thomy", "initials": "T"}, {"family": "Marsaa", "given": "Kristoffer", "initials": "K"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "volume": "56", "issue": "3", "issn-l": "0903-1936"}, "abstract": "Many people are dying from coronavirus disease 2019 (COVID-19), but consensus guidance on palliative care in COVID-19 is lacking. This new life-threatening disease has put healthcare systems under pressure, with the increased need of palliative care provided to many patients by clinicians who have limited prior experience in this field. Therefore, we aimed to make consensus recommendations for palliative care for patients with COVID-19 using the Convergence of Opinion on Recommendations and Evidence (CORE) process.\n\nWe invited 90 international experts to complete an online survey including stating their agreement, or not, with 14 potential recommendations. At least 70% agreement on directionality was needed to provide consensus recommendations. If consensus was not achieved on the first round, a second round was conducted.\n\n68 (75.6%) experts responded in the first round. Most participants were experts in palliative care, respiratory medicine or critical care medicine. In the first round, consensus was achieved on 13 recommendations based upon indirect evidence and clinical experience. In the second round, 58 (85.3%) out of 68 of the first-round experts responded, resulting in consensus for the 14th recommendation.\n\nThis multi-national task force provides consensus recommendations for palliative care for patients with COVID-19 concerning: advance care planning; (pharmacological) palliative treatment of breathlessness; clinician-patient communication; remote clinician-family communication; palliative care involvement in patients with serious COVID-19; spiritual care; psychosocial care; and bereavement care. Future studies are needed to generate empirical evidence for these recommendations.", "doi": "10.1183/13993003.02583-2020", "pmid": "32675211", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "13993003.02583-2020"}, {"db": "pmc", "key": "PMC7366176"}], "notes": [], "created": "2020-12-07T16:35:43.217Z", "modified": "2020-12-07T16:35:43.229Z"}, {"entity": "publication", "iuid": "b28bfa553b78495dabbac185e24c9ec3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b28bfa553b78495dabbac185e24c9ec3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b28bfa553b78495dabbac185e24c9ec3"}}, "title": "COVID-19 in people with multiple sclerosis: A global data sharing initiative.", "authors": [{"family": "Peeters", "given": "Liesbet M", "initials": "LM", "orcid": "0000-0002-6066-3899", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d3fd89e85e4e4368b68b086da3e8cae0.json"}}, {"family": "Parciak", "given": "Tina", "initials": "T"}, {"family": "Walton", "given": "Clare", "initials": "C"}, {"family": "Geys", "given": "Lotte", "initials": "L"}, {"family": "Moreau", "given": "Yves", "initials": "Y"}, {"family": "De Brouwer", "given": "Edward", "initials": "E"}, {"family": "Raimondi", "given": "Daniele", "initials": "D"}, {"family": "Pirmani", "given": "Ashkan", "initials": "A", "orcid": "0000-0003-4549-1002", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d72bbbd407ef4f5387e6653e68e127fc.json"}}, {"family": "Kalincik", "given": "Tomas", "initials": "T"}, {"family": "Edan", "given": "Gilles", "initials": "G"}, {"family": "Simpson-Yap", "given": "Steve", "initials": "S", "orcid": "0000-0001-6521-3056", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/845cbea3a2f64b9f880a43d6cc8cdb09.json"}}, {"family": "De Raedt", "given": "Luc", "initials": "L"}, {"family": "Dauxais", "given": "Yann", "initials": "Y"}, {"family": "Gautrais", "given": "Cl\u00e9ment", "initials": "C", "orcid": "0000-0001-8486-9616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac26ecdf30114e889dca0e02f3e1588d.json"}}, {"family": "Rodrigues", "given": "Paulo R", "initials": "PR"}, {"family": "McKenna", "given": "Landon", "initials": "L"}, {"family": "Lazovski", "given": "Nikola", "initials": "N"}, {"family": "Hillert", "given": "Jan", "initials": "J"}, {"family": "Forsberg", "given": "Lars", "initials": "L"}, {"family": "Spelman", "given": "Tim", "initials": "T", "orcid": "0000-0001-9204-3216", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab24deed7243491387cb220c2a0c8606.json"}}, {"family": "McBurney", "given": "Robert", "initials": "R"}, {"family": "Schmidt", "given": "Hollie", "initials": "H"}, {"family": "Bergmann", "given": "Arnfin", "initials": "A"}, {"family": "Braune", "given": "Stefan", "initials": "S"}, {"family": "Stahmann", "given": "Alexander", "initials": "A"}, {"family": "Middleton", "given": "Rodden", "initials": "R", "orcid": "0000-0002-2130-4420", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7adf9663f3ea4db7b2bfc70b724ad309.json"}}, {"family": "Salter", "given": "Amber", "initials": "A", "orcid": "0000-0002-1088-110X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e108ab0c847c4d5b8e66af7cfb6619ec.json"}}, {"family": "Bebo", "given": "Bruce F", "initials": "BF"}, {"family": "Rojas", "given": "Juan I", "initials": "JI"}, {"family": "van der Walt", "given": "Anneke", "initials": "A", "orcid": "0000-0002-4278-7003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4636e8ba06d94593929e1c30619cc500.json"}}, {"family": "Butzkueven", "given": "Helmut", "initials": "H"}, {"family": "van der Mei", "given": "Ingrid", "initials": "I"}, {"family": "Ivanov", "given": "Rumen", "initials": "R"}, {"family": "Hellwig", "given": "Kerstin", "initials": "K"}, {"family": "Sciascia do Olival", "given": "Guilherme", "initials": "G"}, {"family": "Cohen", "given": "Jeffrey A", "initials": "JA", "orcid": "0000-0001-9245-9772", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c2d691831eb430ea38710e0bec3ad61.json"}}, {"family": "Van Hecke", "given": "Wim", "initials": "W"}, {"family": "Dobson", "given": "Ruth", "initials": "R", "orcid": "0000-0002-2993-585X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b95a061e61124498ba6a11f27e0105dd.json"}}, {"family": "Magyari", "given": "Melinda", "initials": "M"}, {"family": "Brum", "given": "Doralina Guimar\u00e3es", "initials": "DG"}, {"family": "Alonso", "given": "Ricardo", "initials": "R"}, {"family": "Nicholas", "given": "Richard", "initials": "R"}, {"family": "Bauer", "given": "Johana", "initials": "J"}, {"family": "Chertcoff", "given": "Anibal", "initials": "A"}, {"family": "de S\u00e8ze", "given": "J\u00e9r\u00f4me", "initials": "J"}, {"family": "Louapre", "given": "C\u00e9line", "initials": "C"}, {"family": "Comi", "given": "Giancarlo", "initials": "G"}, {"family": "Rijke", "given": "Nick", "initials": "N"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Mult Scler", "issn": "1477-0970", "volume": "26", "issue": "10", "pages": "1157-1162", "issn-l": null}, "abstract": "We need high-quality data to assess the determinants for COVID-19 severity in people with MS (PwMS). Several studies have recently emerged but there is great benefit in aligning data collection efforts at a global scale.\n\nOur mission is to scale-up COVID-19 data collection efforts and provide the MS community with data-driven insights as soon as possible.\n\nNumerous stakeholders were brought together. Small dedicated interdisciplinary task forces were created to speed-up the formulation of the study design and work plan. First step was to agree upon a COVID-19 MS core data set. Second, we worked on providing a user-friendly and rapid pipeline to share COVID-19 data at a global scale.\n\nThe COVID-19 MS core data set was agreed within 48 hours. To date, 23 data collection partners are involved and the first data imports have been performed successfully. Data processing and analysis is an on-going process.\n\nWe reached a consensus on a core data set and established data sharing processes with multiple partners to address an urgent need for information to guide clinical practice. First results show that partners are motivated to share data to attain the ultimate joint goal: better understand the effect of COVID-19 in PwMS.", "doi": "10.1177/1352458520941485", "pmid": "32662757", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7361123"}], "notes": [], "created": "2020-12-08T10:43:30.100Z", "modified": "2023-06-19T14:42:04.913Z"}, {"entity": "publication", "iuid": "2d4895ba0d5e42d19aad6ebf4d7163d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d4895ba0d5e42d19aad6ebf4d7163d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d4895ba0d5e42d19aad6ebf4d7163d5"}}, "title": "Age, Inflammation, and Disease Location Are Critical Determinants of Intestinal Expression of SARS-CoV-2 Receptor ACE2 and TMPRSS2 in Inflammatory Bowel Disease.", "authors": [{"family": "Nowak", "given": "Jan Krzysztof", "initials": "JK"}, {"family": "Lindstr\u00f8m", "given": "Jonas Christoffer", "initials": "JC"}, {"family": "Kalla", "given": "Rahul", "initials": "R"}, {"family": "Ricanek", "given": "Petr", "initials": "P"}, {"family": "Halfvarson", "given": "Jonas", "initials": "J"}, {"family": "Satsangi", "given": "Jack", "initials": "J"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Gastroenterology", "issn": "1528-0012", "issn-l": null, "volume": "159", "issue": "3", "pages": "1151-1154.e2"}, "abstract": null, "doi": "10.1053/j.gastro.2020.05.030", "pmid": "32413354", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0016-5085(20)30653-3"}, {"db": "pmc", "key": "PMC7217073"}], "notes": [], "created": "2020-12-10T08:52:09.765Z", "modified": "2021-02-26T08:45:47.984Z"}, {"entity": "publication", "iuid": "b7ed4f4a0b3d4a3da337cd6166d65ef7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b7ed4f4a0b3d4a3da337cd6166d65ef7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b7ed4f4a0b3d4a3da337cd6166d65ef7"}}, "title": "A snapshot of European neurosurgery December 2019 vs. March 2020: just before and during the Covid-19 pandemic.", "authors": [{"family": "Mathiesen", "given": "T", "initials": "T"}, {"family": "Arraez", "given": "M", "initials": "M"}, {"family": "Asser", "given": "T", "initials": "T"}, {"family": "Balak", "given": "N", "initials": "N"}, {"family": "Barazi", "given": "S", "initials": "S"}, {"family": "Bernucci", "given": "C", "initials": "C"}, {"family": "Bolger", "given": "C", "initials": "C"}, {"family": "Broekman", "given": "M L D", "initials": "MLD"}, {"family": "Demetriades", "given": "A K", "initials": "AK"}, {"family": "Feldman", "given": "Z", "initials": "Z"}, {"family": "Fontanella", "given": "M M", "initials": "MM"}, {"family": "Foroglou", "given": "N", "initials": "N"}, {"family": "Lafuente", "given": "J", "initials": "J"}, {"family": "Maier", "given": "A D", "initials": "AD"}, {"family": "Meyer", "given": "B", "initials": "B"}, {"family": "Niemel\u00e4", "given": "M", "initials": "M"}, {"family": "Roche", "given": "P H", "initials": "PH"}, {"family": "Sala", "given": "F", "initials": "F"}, {"family": "Sampr\u00f3n", "given": "N", "initials": "N"}, {"family": "Sandvik", "given": "U", "initials": "U"}, {"family": "Schaller", "given": "K", "initials": "K"}, {"family": "Thome", "given": "C", "initials": "C"}, {"family": "Thys", "given": "M", "initials": "M"}, {"family": "Tisell", "given": "M", "initials": "M"}, {"family": "Vajkoczy", "given": "P", "initials": "P"}, {"family": "Visocchi", "given": "M", "initials": "M"}, {"family": "EANS Ethico-legal committee", "given": "", "initials": ""}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Acta Neurochir (Wien)", "issn": "0942-0940", "volume": "162", "issue": "9", "pages": "2221-2233", "issn-l": "0001-6268"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or Covid-19), which began as an epidemic in China and spread globally as a pandemic, has necessitated resource management to meet emergency needs of Covid-19 patients and other emergent cases. We have conducted a survey to analyze caseload and measures to adapt indications for a perception of crisis.\n\nWe constructed a questionnaire to survey a snapshot of neurosurgical activity, resources, and indications during 1 week with usual activity in December 2019 and 1 week during SARS-CoV-2 pandemic in March 2020. The questionnaire was sent to 34 neurosurgical departments in Europe; 25 departments returned responses within 5 days.\n\nWe found unexpectedly large differences in resources and indications already before the pandemic. Differences were also large in how much practice and resources changed during the pandemic. Neurosurgical beds and neuro-intensive care beds were significantly decreased from December 2019 to March 2020. The utilization of resources decreased via less demand for care of brain injuries and subarachnoid hemorrhage, postponing surgery and changed surgical indications as a method of rationing resources. Twenty departments (80%) reduced activity extensively, and the same proportion stated that they were no longer able to provide care according to legitimate medical needs.\n\nNeurosurgical centers responded swiftly and effectively to a sudden decrease of neurosurgical capacity due to relocation of resources to pandemic care. The pandemic led to rationing of neurosurgical care in 80% of responding centers. We saw a relation between resources before the pandemic and ability to uphold neurosurgical services. The observation of extensive differences of available beds provided an opportunity to show how resources that had been restricted already under normal conditions translated to rationing of care that may not be acceptable to the public of seemingly affluent European countries.", "doi": "10.1007/s00701-020-04482-8", "pmid": "32642834", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00701-020-04482-8"}, {"db": "pmc", "key": "PMC7343382"}], "notes": [], "created": "2020-12-08T14:30:29.037Z", "modified": "2020-12-08T14:30:29.046Z"}, {"entity": "publication", "iuid": "8e1aad5a6c4d4b588eb1de6f6cb85a2b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e1aad5a6c4d4b588eb1de6f6cb85a2b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e1aad5a6c4d4b588eb1de6f6cb85a2b"}}, "title": "A critical review of the pathophysiology of thrombotic complications and clinical practice recommendations for thromboprophylaxis in pregnant patients with COVID-19.", "authors": [{"family": "D'Souza", "given": "Rohan", "initials": "R"}, {"family": "Malham\u00e9", "given": "Isabelle", "initials": "I"}, {"family": "Teshler", "given": "Lizabeth", "initials": "L"}, {"family": "Acharya", "given": "Ganesh", "initials": "G"}, {"family": "Hunt", "given": "Beverley J", "initials": "BJ"}, {"family": "McLintock", "given": "Claire", "initials": "C"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "9", "pages": "1110-1120", "issn-l": "0001-6349"}, "abstract": "Those who are infected with Severe Acute Respiratory Syndrome-related CoronaVirus-2 are theoretically at increased risk of venous thromboembolism during self-isolation if they have reduced mobility or are dehydrated. Should patients develop coronavirus disease (COVID-19) pneumonia requiring hospital admission for treatment of hypoxia, the risk for thromboembolic complications increases greatly. These thromboembolic events are the result of at least two distinct mechanisms - microvascular thrombosis in the pulmonary system (immunothrombosis) and hospital-associated venous thromboembolism. Since pregnancy is a prothrombotic state, there is concern regarding the potentially increased risk of thrombotic complications among pregnant women with COVID-19. To date, however, pregnant women do not appear to have a substantially increased risk of thrombotic complications related to COVID-19. Nevertheless, several organizations have vigilantly issued pregnancy-specific guidelines for thromboprophylaxis in COVID-19. Discrepancies between these guidelines reflect the altruistic wish to protect patients and lack of high-quality evidence available to inform clinical practice. Low molecular weight heparin (LMWH) is the drug of choice for thromboprophylaxis in pregnant women with COVID-19. However, its utility in non-pregnant patients is only established against venous thromboembolism, as LMWH may have little or no effect on immunothrombosis. Decisions about initiation and duration of prophylactic anticoagulation in the context of pregnancy and COVID-19 must take into consideration disease severity, outpatient vs inpatient status, temporal relation between disease occurrence and timing of childbirth, and the underlying prothrombotic risk conferred by additional comorbidities. There is currently no evidence to recommend the use of intermediate or therapeutic doses of LMWH in thromboprophylaxis, which may increase bleeding risk without reducing thrombotic risk in pregnant patients with COVID-19. Likewise, there is no evidence to comment on the role of low-dose aspirin in thromboprophylaxis or of anti-cytokine and antiviral agents in preventing immunothrombosis. These unanswered questions are being studied within the context of clinical trials.", "doi": "10.1111/aogs.13962", "pmid": "32678949", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7404828"}], "notes": [], "created": "2020-11-26T12:14:06.219Z", "modified": "2020-11-30T08:45:13.568Z"}, {"entity": "publication", "iuid": "aeeb2de8be7c4b6dacb136d427561a49", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aeeb2de8be7c4b6dacb136d427561a49.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aeeb2de8be7c4b6dacb136d427561a49"}}, "title": "The SARS-CoV-2 N Protein Is a Good Component in a Vaccine.", "authors": [{"family": "Ahl\u00e9n", "given": "Gustaf", "initials": "G"}, {"family": "Frelin", "given": "Lars", "initials": "L"}, {"family": "Nikouyan", "given": "Negin", "initials": "N"}, {"family": "Weber", "given": "Friedemann", "initials": "F"}, {"family": "H\u00f6glund", "given": "Urban", "initials": "U"}, {"family": "Larsson", "given": "Olivia", "initials": "O"}, {"family": "Westman", "given": "Marie", "initials": "M"}, {"family": "Tuvesson", "given": "Ola", "initials": "O"}, {"family": "Gidlund", "given": "Eva-Karin", "initials": "EK"}, {"family": "Cadossi", "given": "Matteo", "initials": "M"}, {"family": "Appelberg", "given": "Sofia", "initials": "S"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "S\u00e4llberg", "given": "Matti", "initials": "M"}, {"family": "OPENCORONA Consortium", "given": "", "initials": ""}], "type": "letter", "published": "2020-08-31", "journal": {"title": "J Virol", "issn": "0022-538X", "volume": "94", "issue": "18", "issn-l": null}, "abstract": null, "doi": "10.1128/JVI.01279-20", "pmid": "32661140", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "JVI.01279-20"}, {"db": "pmc", "key": "PMC7459553"}], "notes": [], "created": "2020-11-19T19:35:23.241Z", "modified": "2020-12-08T10:44:08.917Z"}, {"entity": "publication", "iuid": "d813fde6181648e4abcc5ebc6d6c9cd6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d813fde6181648e4abcc5ebc6d6c9cd6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d813fde6181648e4abcc5ebc6d6c9cd6"}}, "title": "Screening for natural and derived bio-active compounds in preclinical and clinical studies: One of the frontlines of fighting the coronaviruses pandemic.", "authors": [{"family": "Khalifa", "given": "Shaden A M", "initials": "SAM"}, {"family": "Yosri", "given": "Nermeen", "initials": "N"}, {"family": "El-Mallah", "given": "Mohamed F", "initials": "MF"}, {"family": "Ghonaim", "given": "Reem", "initials": "R"}, {"family": "Guo", "given": "Zhiming", "initials": "Z"}, {"family": "Musharraf", "given": "Syed Ghulam", "initials": "SG"}, {"family": "Du", "given": "Ming", "initials": "M"}, {"family": "Khatib", "given": "Alfi", "initials": "A"}, {"family": "Xiao", "given": "Jianbo", "initials": "J"}, {"family": "Saeed", "given": "Aamer", "initials": "A"}, {"family": "El-Seedi", "given": "Haged H R", "initials": "HHR"}, {"family": "Zhao", "given": "Chao", "initials": "C"}, {"family": "Efferth", "given": "Thomas", "initials": "T"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}], "type": "journal article", "published": "2020-08-29", "journal": {"title": "Phytomedicine", "issn": "1618-095X", "volume": null, "issue": null, "pages": "153311", "issn-l": "0944-7113"}, "abstract": "Starting December 2019, mankind faced an unprecedented enemy, the COVID-19 virus. The world convened in international efforts, experiences and technologies in order to fight the emerging pandemic. Isolation, hygiene measure, diagnosis, and treatment are the most efficient ways of prevention and intervention nowadays. The health organizations and global care systems screened the available resources and offered recommendations of approved and proposed medications. However, the search for a specific selective therapy or vaccine against COVID-19 remains a challenge.\n\nA literature search was performed for the screening of natural and derived bio-active compounds which showed potent antiviral activity against coronaviruses using published articles, patents, clinical trials website (https://clinicaltrials.gov/) and web databases (PubMed, SCI Finder, Science Direct, and Google Scholar).\n\nThrough the screening for natural products with antiviral activities against different types of the human coronavirus, extracts of Lycoris radiata (L'H\u00e9r.), Gentiana scabra Bunge, Dioscorea batatas Decne., Cassia tora L., Taxillus chinensis (DC.), Cibotium barometz L. and Echinacea purpurea L. showed a promising effect against SARS-CoV. Out of the listed compound Lycorine, emetine dihydrochloride hydrate, pristimerin, harmine, conessine, berbamine, 4`-hydroxychalcone, papaverine, mycophenolic acid, mycophenolate mofetil, monensin sodium, cycloheximide, oligomycin and valinomycin show potent activity against human coronaviruses. Additionally, it is worth noting that some compounds have already moved into clinical trials for their activity against COVID-19 including fingolimod, methylprednisolone, chloroquine, tetrandrine and tocilizumab.\n\nNatural compounds and their derivatives could be used for developing potent therapeutics with significant activity against SARS-COV-2, providing a promising frontline in the fighting against COVID-19.", "doi": "10.1016/j.phymed.2020.153311", "pmid": "33067112", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0944-7113(20)30143-4"}, {"db": "pmc", "key": "PMC7455571"}], "notes": [], "created": "2020-11-26T12:33:13.706Z", "modified": "2020-11-27T11:51:36.346Z"}, {"entity": "publication", "iuid": "d1d9102f7bcc4023a72f702c84f034bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1d9102f7bcc4023a72f702c84f034bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1d9102f7bcc4023a72f702c84f034bd"}}, "title": "SARS-CoV-2 RNA in serum as predictor of severe outcome in COVID-19: a retrospective cohort study.", "authors": [{"family": "Hagman", "given": "Karl", "initials": "K"}, {"family": "Hedenstierna", "given": "Magnus", "initials": "M"}, {"family": "Gille-Johnson", "given": "Patrik", "initials": "P"}, {"family": "Hammas", "given": "Berit", "initials": "B"}, {"family": "Grabbe", "given": "Malin", "initials": "M"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Ursing", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2020-08-28", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "issn-l": "1058-4838", "volume": null, "issue": null, "pages": null}, "abstract": "Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes Coronavirus disease 2019 (COVID-19). This study aimed to determine if SARS-CoV-2 RNA in serum at admission correlated with clinical outcome in COVID-19.\r\n\r\nCOVID-19 patients admitted to the Infectious Diseases department of a tertiary level Swedish hospital, and sampled for SARS-CoV-2 RNA in serum at admission, April 10 to June 30 2020 were included in a cohort. Primary outcomes were day 28 all-cause mortality and progress to critical disease.\r\n\r\nThe cohort (N=167) consisted of 106 SARS-CoV-2 RNA serum negative and 61 positive patients. Median sampling time for initial SARS-CoV-2 in serum was 1 (IQR 1-2) day after admission corresponding to day 10 (IQR 8-12) after symptom onset. Median ages were 53 (IQR 44-67) and 63 (IQR 52-74) years for the PCR-negative and positive patients, respectively. In the serum PCR negative and positive groups 3/106 and 15/61 patients died, respectively.The hazard ratios for critical disease and all-cause mortality were 7.2 (95% CI 3.0-17) and 8.6 (95% CI 2.4-30), respectively for patients that were serum PCR positive compared to serum PCR negative.Conclusion: SARS-CoV-2 RNA in serum at hospital admission indicates a high-risk of progression to critical disease and death.", "doi": "10.1093/cid/ciaa1285", "pmid": "32856036", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "5898271"}, {"db": "pmc", "key": "PMC7499508"}], "notes": [], "created": "2020-12-04T08:59:08.585Z", "modified": "2021-02-26T08:45:48.744Z"}, {"entity": "publication", "iuid": "1edfbec48fb445bd9b215700435d8ded", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1edfbec48fb445bd9b215700435d8ded.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1edfbec48fb445bd9b215700435d8ded"}}, "title": "A case-report of widespread pulmonary embolism in a middle-aged male seven weeks after asymptomatic suspected COVID 19 infection.", "authors": [{"family": "Beckman", "given": "Mats", "initials": "M"}, {"family": "Nyr\u00e9n", "given": "Sven", "initials": "S"}, {"family": "Kistner", "given": "Anna", "initials": "A"}], "type": "case reports", "published": "2020-08-28", "journal": {"title": "Thromb J", "issn": "1477-9560", "volume": "18", "issue": null, "pages": "19", "issn-l": null}, "abstract": "Pulmonary embolism (PE) is seen in high frequency in hospital-treated patients with Covid-19. We present a case of suspected Covid-19 with long-term dyspnea and widespread PE.\n\nA 51- year old male, with no prior medical history, no medication, and non-smoker arrived at the emergency department with exercise induced dyspnea during 4-5 weeks and for the last 48 h dyspnea at rest. Seven weeks before hospitalization, he felt difficulties taking deep breaths for some days but no other symptoms. Oxygen saturation at rest was 93%. Troponin T was 1200 mg/L (ref < 15 mg/L). CT angiography revealed widespread bilateral segmental pulmonary embolism. Additional findings were ground glass opacities that could match Covid-19. The patient tested negative for SARS -CoV-2. Full dose tinzaparin was given for 2 days in hospital, followed by apixaban for 6 months. Recovery has been uneventful so far.\n\nLong-term breathing difficulties might be relatively common after non-hospitalized symptomatic Covid-19. The frequency of PE in this group is unknown. We report a case of suspected covid-19 with widespread PE and a long history of dyspnea but no other symptoms. In our case slight hypoxia and laboratory testing indicated significant disease, which was proven with contrast angiography. This case shows that PE is a differential diagnosis in non-hospitalized symptomatic Covid-19 with persisting breathing problems.", "doi": "10.1186/s12959-020-00235-w", "pmid": "32868974", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "235"}, {"db": "pmc", "key": "PMC7453687"}], "notes": [], "created": "2020-12-07T07:50:31.006Z", "modified": "2021-02-26T08:45:47.937Z"}, {"entity": "publication", "iuid": "69088da76ece4cee8ec3e363bdd5b05b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69088da76ece4cee8ec3e363bdd5b05b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69088da76ece4cee8ec3e363bdd5b05b"}}, "title": "Stressors, coping and symptoms of adjustment disorder in the course of the COVID-19 pandemic - study protocol of the European Society for Traumatic Stress Studies (ESTSS) pan-European study.", "authors": [{"family": "Lotzin", "given": "Annett", "initials": "A"}, {"family": "Acquarini", "given": "Elena", "initials": "E"}, {"family": "Ajdukovic", "given": "Dean", "initials": "D"}, {"family": "Ardino", "given": "Vittoria", "initials": "V"}, {"family": "B\u00f6ttche", "given": "Maria", "initials": "M"}, {"family": "Bondjers", "given": "Kristina", "initials": "K"}, {"family": "Bragesj\u00f6", "given": "Maria", "initials": "M"}, {"family": "Dragan", "given": "Ma\u0142gorzata", "initials": "M"}, {"family": "Grajewski", "given": "Piotr", "initials": "P"}, {"family": "Figueiredo-Braga", "given": "Margarida", "initials": "M"}, {"family": "Gelezelyte", "given": "Odeta", "initials": "O"}, {"family": "Javakhishvili", "given": "Jana Darejan", "initials": "JD"}, {"family": "Kazlauskas", "given": "Evaldas", "initials": "E"}, {"family": "Knefel", "given": "Matthias", "initials": "M"}, {"family": "Lueger-Schuster", "given": "Brigitte", "initials": "B"}, {"family": "Makhashvili", "given": "Nino", "initials": "N"}, {"family": "Mooren", "given": "Trudy", "initials": "T"}, {"family": "Sales", "given": "Luisa", "initials": "L"}, {"family": "Stevanovic", "given": "Aleksandra", "initials": "A"}, {"family": "Sch\u00e4fer", "given": "Ingo", "initials": "I"}], "type": "journal article", "published": "2020-08-27", "journal": {"title": "Eur J Psychotraumatol", "issn": "2000-8066", "issn-l": null, "volume": "11", "issue": "1", "pages": "1780832"}, "abstract": "During the current COVID-19 pandemic, the people in Europe are exposed to self-isolation, quarantine, job loss, risk of contracting COVID-19, or grief of loved ones. Such a complex array of stressors may lead to symptoms of adjustment disorder or posttraumatic stress disorder. This research protocol describes a study launched by the European Society of Traumatic Stress Studies (ESTSS) to investigate the impact of the COVID-19 pandemic on symptoms of adjustment disorder across European countries.\r\n\r\nThe longitudinal online cohort study aims (1) to explore psychosocial reactions to the COVID-19 pandemic across ten European countries; (2) to examine the relationships between risk and resilience factors, stressors and symptoms of adjustment disorder during the pandemic; and (3) to investigate whether these relationships are moderated by coping behaviours.\r\n\r\nIn ten countries (Austria, Croatia, Georgia, Germany, Italy, Lithuania, Netherlands, Poland, Portugal, and Sweden), between 1,000 and 2,000 participants will be recruited, depending on the size of the country. Participants will be assessed at two timepoints with a six-month interval. Following a conceptual framework based on the WHO's social framework of health, an assessment of risk and resilience factors, COVID-19 related stressors and pandemic-specific coping behaviours will be measured to estimate their contribution to symptoms of adjustment disorder. The Adjustment Disorder New Module 8 (ADNM-8) will be used to assess symptoms of adjustment disorder. As a secondary measure, symptoms of posttraumatic stress disorder will be measure using the Primary Care PTSD Screen for DSM-5 (PC-PTSD-5).\r\n\r\nThe relative contribution of risk factors, resilience factors, and stressors on symptoms of adjustment disorder or symptoms of posttraumatic stress disorder will be estimated using multilevel analysis. To determine the moderating effects of different types of coping behaviours on these relationships, a multilevel mediation analysis will be carried out.", "doi": "10.1080/20008198.2020.1780832", "pmid": "33029321", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "1780832"}, {"db": "pmc", "key": "PMC7473046"}], "notes": [], "created": "2020-12-01T17:33:46.838Z", "modified": "2022-11-10T06:53:25.923Z"}, {"entity": "publication", "iuid": "d8fc9caf2b854bb09e32120e40f11dbb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d8fc9caf2b854bb09e32120e40f11dbb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d8fc9caf2b854bb09e32120e40f11dbb"}}, "title": "Quality Assessment of the Chinese Clinical Trial Protocols Regarding Treatments for Coronavirus Disease 2019.", "authors": [{"family": "Zhang", "given": "Jiaxing", "initials": "J"}, {"family": "Lu", "given": "Yiling", "initials": "Y"}, {"family": "Kwong", "given": "Joey Sum-Wing", "initials": "JS"}, {"family": "Li", "given": "Xiaosi", "initials": "X"}, {"family": "Zheng", "given": "Wenyi", "initials": "W"}, {"family": "He", "given": "Rui", "initials": "R"}], "type": "systematic review", "published": "2020-08-27", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "11", "issue": null, "pages": "1330", "issn-l": "1663-9812"}, "abstract": "With the global spread of coronavirus disease 2019 (COVID-19), an increasing number of clinical trials are being designed and executed to evaluate the efficacy and safety of various therapies for COVID-19. We conducted this survey to assess the methodological quality of registry protocols on potential treatments for COVID-19.\n\nClinical trial protocols were identified on the ClinicalTrials.gov and the Chinese Clinical Trial Registry. Protocols were screened by two investigators independently against pre-defined eligibility criteria. Quality of the included protocols was assessed according to the modified 14-item SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2013 Statement.\n\nWe included 82 randomized controlled trial (RCT) protocols investigating treatment modalities for COVID-19. These ongoing trials are being conducted in 16 provinces, autonomous regions, and municipalities of China, and study interventions were either Western medicines (n = 56) or traditional Chinese medicine (n = 26). Findings of our quality assessment indicated that the existing trial protocols could be further improved on several aspects, including selection and definition of outcome measures, descriptions of study interventions and comparators, study subject recruitment time, definition of study inclusion and exclusion criteria, and allocation concealment methods. Descriptions of random sequence generation methodologies were accurate for the majority of included trial protocols (n = 64; 78.05%); however, reporting of allocation concealment remained unclear in 63 (76.83%) protocols. Therefore, the overall risk of selection bias across these RCTs was judged to be unclear. A total of 52 (63.41%) included RCT protocols were open-label trials and are thus associated with a high risk of performance bias and detection bias.\n\nQuality of currently available RCT protocols on the treatments for COVID-19 could be further improved. For transparency and effective knowledge translation in real-world clinically settings, it is important for trial investigators to standardize baseline treatments for patients with COVID-19 and assess clinically important core outcome measures. Despite eager anticipation from the public on the results of effectiveness trials in COVID-19, robust design, execution, and reporting of these trials should be regarded as high priority.", "doi": "10.3389/fphar.2020.01330", "pmid": "32973535", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7481475"}], "notes": [], "created": "2020-11-26T12:35:59.498Z", "modified": "2020-11-27T12:42:08.264Z"}, {"entity": "publication", "iuid": "5dede475e5044e6fbfba60106ec06167", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5dede475e5044e6fbfba60106ec06167.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5dede475e5044e6fbfba60106ec06167"}}, "title": "Four SARS-CoV-2 Genome Sequences from Late April in Stockholm, Sweden, Reveal a Rare Mutation in the Spike Protein", "authors": [{"family": "Soratto", "given": "Tatiany Aparecida Teixeira", "initials": "TAT"}, {"family": "Darban", "given": "Hamid", "initials": "H"}, {"family": "Bjerkner", "given": "Annelie", "initials": "A"}, {"family": "Coorens", "given": "Maarten", "initials": "M"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Allander", "given": "Tobias", "initials": "T"}, {"family": "Andersson", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal-article", "published": "2020-08-27", "journal": {"title": "Microbiol Resour Announc", "issn": "2576-098X", "volume": "9", "issue": "35", "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1128/mra.00934-20", "pmid": null, "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Health": null}, "xrefs": [{"db": "ENA", "key": "https://www.ebi.ac.uk/ena/browser/view/PRJEB39632", "description": "ENA PRJEB39632: SARS-CoV-2 genomes from late April in Stockholm, Sweden (reads and consensus sequences)"}], "notes": [], "created": "2021-01-20T12:57:49.990Z", "modified": "2021-11-18T08:48:14.869Z"}, {"entity": "publication", "iuid": "1b2f511e17b149f28b7964815215754a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b2f511e17b149f28b7964815215754a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b2f511e17b149f28b7964815215754a"}}, "title": "The Impact and Consequences of SARS-CoV-2 Pandemic on a Single University Dermatology Outpatient Clinic in Germany.", "authors": [{"family": "Wang", "given": "Rosi", "initials": "R"}, {"family": "Helf", "given": "Charlotte", "initials": "C"}, {"family": "Tizek", "given": "Linda", "initials": "L"}, {"family": "Neuhauser", "given": "Ruth", "initials": "R"}, {"family": "Eyerich", "given": "Kilian", "initials": "K"}, {"family": "Zink", "given": "Alexander", "initials": "A"}, {"family": "Eberlein", "given": "Bernadette", "initials": "B"}, {"family": "Biedermann", "given": "Tilo", "initials": "T"}, {"family": "Brockow", "given": "Knut", "initials": "K"}, {"family": "Boehner", "given": "Alexander", "initials": "A"}], "type": "journal article", "published": "2020-08-26", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "17", "pages": null}, "abstract": "The pandemic outbreak of coronavirus disease 2019 (COVID-19) affects health care systems globally and leads to other challenges besides infection and its direct medical consequences. The aim of this study was to investigate the impact of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic on the university dermatology outpatient clinic (UDOC) of the Technical University of Munich, Germany. We analyzed datasets from 2015 until 2020 extracted from the hospital information system database and our documented outpatient files regarding patient numbers, gender, age, and diagnoses. In 2020, case numbers of outpatient care declined significantly ( p = 0.021) compared to previous years and was related to the timing of political announcements answering SARS-CoV-2 pandemic. Additionally, during calendar week 10 to 15-the peak time of the spread of COVID-19 in Germany-the proportion of patients missing their consultation was significantly higher in 2020 than in 2019 (22.4% vs. 12.4%; p < 0.001). Gender-associated differences regarding absences were not detected, but patients aged 85 years or older were significantly more likely to miss their consultation compared to all other age groups (p = 0.002). Regarding different disease clusters, patients with chronic inflammatory skin diseases and infectious and malignant diseases were more likely to miss their consultation (p = 0.006). Noticeably, less patients with malignant diseases, and particularly malignant melanoma, were registered during this pandemic. Our data support the hypothesis that medically constructive prioritization might not be implemented properly by patients themselves. Identifying missed patients and catching up on their medical care apart from COVID-19 will pose an enormous challenge for health care systems globally.", "doi": "10.3390/ijerph17176182", "pmid": "32858870", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "ijerph17176182"}, {"db": "pmc", "key": "PMC7504311"}], "notes": [], "created": "2020-12-07T10:21:15.928Z", "modified": "2022-11-10T06:54:44.823Z"}, {"entity": "publication", "iuid": "412ce737cca4490db9b405d33efbdd05", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/412ce737cca4490db9b405d33efbdd05.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/412ce737cca4490db9b405d33efbdd05"}}, "title": "Psychological impact of COVID-19 in the Swedish population: Depression, anxiety, and insomnia and their associations to risk and vulnerability factors.", "authors": [{"family": "McCracken", "given": "Lance M", "initials": "LM"}, {"family": "Badinlou", "given": "Farzaneh", "initials": "F"}, {"family": "Buhrman", "given": "Monica", "initials": "M"}, {"family": "Brocki", "given": "Karin C", "initials": "KC"}], "type": "journal article", "published": "2020-08-26", "journal": {"title": "Eur Psychiatry", "issn": "1778-3585", "issn-l": "0924-9338", "volume": "63", "issue": "1", "pages": "e81"}, "abstract": "The 2019 coronavirus disease (COVID-19) pandemic, with its associated restrictions on daily life, is like a perfect storm for poor mental health and wellbeing. The purpose of this study was therefore to examine the impacts of COVID-19 on mental health and wellbeing during the ongoing pandemic in Sweden.\r\n\r\nStandardized measures of depression, anxiety, and insomnia as well as measures of risk and vulnerability factors known to be associated with poor mental health outcomes were administered through a national, online, cross-sectional survey (n = 1,212; mean age 36.1 years; 73% women).\r\n\r\nOur findings show significant levels of depression, anxiety, and insomnia in Sweden, at rates of 30%, 24.2%, and 38%, respectively. The strongest predictors of these outcomes included poor self-rated overall health and a history of mental health problems. The presence of COVID-19 symptoms and specific health and financial worries related to the pandemic also appeared important.\r\n\r\nThe impacts of COVID-19 on mental health in Sweden are comparable to impacts shown in previous studies in Italy and China. Importantly, the pandemic seems to impose most on the mental health of those already burdened with the impacts of mental health problems. These results provide a basis for providing more support for vulnerable groups, and for developing psychological interventions suited to the ongoing pandemic and for similar events in the future.", "doi": "10.1192/j.eurpsy.2020.81", "pmid": "32843115", "labels": {"Type: Journal article": null, "Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0924933820000814"}, {"db": "pmc", "key": "PMC7503043"}], "notes": [], "created": "2020-11-22T09:57:25.705Z", "modified": "2022-11-10T06:55:13.268Z"}, {"entity": "publication", "iuid": "15f244f3562b4f0fb95392207e8d9726", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15f244f3562b4f0fb95392207e8d9726.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15f244f3562b4f0fb95392207e8d9726"}}, "title": "Thinking strategically for COVID-19: suppress and lift, to flatten or to crush?", "authors": [{"family": "Khalife", "given": "Jade", "initials": "J"}], "type": "journal article", "published": "2020-08-25", "journal": {"title": "East Mediterr Health J", "issn": "1687-1634", "volume": "26", "issue": "8", "pages": "877-878", "issn-l": null}, "abstract": null, "doi": "10.26719/emhj.20.091", "pmid": "32896879", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-06T07:17:29.471Z", "modified": "2020-12-06T07:17:29.492Z"}, {"entity": "publication", "iuid": "47b726dd88e94d50acb444651310dee1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47b726dd88e94d50acb444651310dee1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47b726dd88e94d50acb444651310dee1"}}, "title": "Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19.", "authors": [{"family": "Rodriguez", "given": "Lucie", "initials": "L"}, {"family": "Pekkarinen", "given": "Pirkka T", "initials": "PT"}, {"family": "Lakshmikanth", "given": "Tadepally", "initials": "T"}, {"family": "Tan", "given": "Ziyang", "initials": "Z"}, {"family": "Consiglio", "given": "Camila Rosat", "initials": "CR"}, {"family": "Pou", "given": "Christian", "initials": "C"}, {"family": "Chen", "given": "Yang", "initials": "Y"}, {"family": "Mugabo", "given": "Constantin Habimana", "initials": "CH"}, {"family": "Nguyen", "given": "Ngoc Anh", "initials": "NA"}, {"family": "Nowlan", "given": "Kirsten", "initials": "K"}, {"family": "Strandin", "given": "Tomas", "initials": "T"}, {"family": "Levanov", "given": "Lev", "initials": "L"}, {"family": "Mikes", "given": "Jaromir", "initials": "J"}, {"family": "Wang", "given": "Jun", "initials": "J"}, {"family": "Kantele", "given": "Anu", "initials": "A"}, {"family": "Hepojoki", "given": "Jussi", "initials": "J"}, {"family": "Vapalahti", "given": "Olli", "initials": "O"}, {"family": "Heinonen", "given": "Santtu", "initials": "S"}, {"family": "Kek\u00e4l\u00e4inen", "given": "Eliisa", "initials": "E"}, {"family": "Brodin", "given": "Petter", "initials": "P"}], "type": "journal article", "published": "2020-08-25", "journal": {"title": "Cell Rep Med", "issn": "2666-3791", "issn-l": "2666-3791", "volume": "1", "issue": "5", "pages": "100078"}, "abstract": "Severe disease of SARS-CoV-2 is characterized by vigorous inflammatory responses in the lung, often with a sudden onset after 5-7 days of stable disease. Efforts to modulate this hyperinflammation and the associated acute respiratory distress syndrome rely on the unraveling of the immune cell interactions and cytokines that drive such responses. Given that every patient is captured at different stages of infection, longitudinal monitoring of the immune response is critical and systems-level analyses are required to capture cellular interactions. Here, we report on a systems-level blood immunomonitoring study of 37 adult patients diagnosed with COVID-19 and followed with up to 14 blood samples from acute to recovery phases of the disease. We describe an IFN\u03b3-eosinophil axis activated before lung hyperinflammation and changes in cell-cell co-regulation during different stages of the disease. We also map an immune trajectory during recovery that is shared among patients with severe COVID-19.", "doi": "10.1016/j.xcrm.2020.100078", "pmid": "32838342", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://ki.app.box.com/s/sby0jesyu23a65cbgv51vpbzqjdmipr1", "description": "Raw mass cytometry data and the Olink protein data"}, {"db": "URL", "key": "https://github.com/rodriluc/SARS-CoV2_study", "description": "Analysis code"}, {"db": "URL", "key": "https://www.cell.com/cms/10.1016/j.xcrm.2020.100078/attachment/53aca693-33e7-4b26-881f-ea11c7c15ad1/mmc1.pdf", "description": "IgG data"}], "notes": [], "created": "2020-10-28T09:10:41.202Z", "modified": "2021-02-26T08:45:48.110Z"}, {"entity": "publication", "iuid": "b07cf88cd3a84c39b27242bbb46c99b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b07cf88cd3a84c39b27242bbb46c99b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b07cf88cd3a84c39b27242bbb46c99b3"}}, "title": "Social distancing laws cause only small losses of economic activity during the COVID-19 pandemic in Scandinavia.", "authors": [{"family": "Sheridan", "given": "Adam", "initials": "A"}, {"family": "Andersen", "given": "Asger Lau", "initials": "AL"}, {"family": "Hansen", "given": "Emil Toft", "initials": "ET"}, {"family": "Johannesen", "given": "Niels", "initials": "N"}], "type": "journal article", "published": "2020-08-25", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "117", "issue": "34", "pages": "20468-20473", "issn-l": "0027-8424"}, "abstract": "This paper uses real-time transaction data from a large bank in Scandinavia to estimate the effect of social distancing laws on consumer spending in the coronavirus 2019 (COVID-19) pandemic. The analysis exploits a natural experiment to disentangle the effects of the virus and the laws aiming to contain it: Denmark and Sweden were similarly exposed to the pandemic but only Denmark imposed significant restrictions on social and economic activities. We estimate that aggregate spending dropped by around 25% (95% CI: 24 to 26%) in Sweden and, as a result of the shutdown, by 4 additional percentage points (95% CI: 3 to 5 percentage points [p.p.]) in Denmark. This suggests that most of the economic contraction is caused by the virus itself and occurs regardless of social distancing laws. The age gradient in the estimates suggests that social distancing reinforces the virus-induced drop in spending for low-health-risk individuals but attenuates it for high-risk individuals by lowering the overall prevalence of the virus in the society.", "doi": "10.1073/pnas.2010068117", "pmid": "32747573", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2010068117"}, {"db": "pmc", "key": "PMC7456178"}], "notes": [], "created": "2020-12-07T16:00:21.918Z", "modified": "2020-12-07T16:00:21.930Z"}, {"entity": "publication", "iuid": "1e96656d2f8b4ace83a45b4423931a25", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1e96656d2f8b4ace83a45b4423931a25.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1e96656d2f8b4ace83a45b4423931a25"}}, "title": "Interventions to suppress the coronavirus pandemic will increase unemployment and lead to many premature deaths.", "authors": [{"family": "Ros\u00e9n", "given": "M\u00e5ns", "initials": "M"}, {"family": "Stenbeck", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2020-08-25", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": null, "issue": null, "pages": "1403494820947974"}, "abstract": "Interventions to suppress the coronavirus pandemic have led to economic recession and higher unemployment, which will increase mortality and decrease quality of life. The aim of this article is to estimate the consequences on mortality and life expectancy of increased unemployment rates due to the coronavirus pandemic in Sweden and other countries.\r\n\r\nBased on recent increases and expected future unemployment rates due to the coronavirus pandemic, results from a systematic review and data from vital statistics in Sweden, the number of premature deaths due to unemployment in Sweden have been estimated.\r\n\r\nBased on our assumptions, the calculations show that if the number of unemployed persons in Sweden increases by 100,000, one may expect some 1800 more premature deaths during the following 9 years. If the duration of the recession is limited to 4 years, excess deaths due to unemployment may be around 800. On average, the unemployed will lose 2 years of their remaining life expectancy. In many other countries unemployment rates have or are estimated to rise more than in Sweden, sometimes two- or threefold, suggesting hundreds of thousands of excess deaths due to unemployment.\r\n\r\nInterventions to suppress the coronavirus pandemic include the shut-down of economic activities and lead to increased all-cause mortality. These public health effects must be considered in the decision-making process and should be added to overall estimates of the effects of the pandemic on public health.", "doi": "10.1177/1403494820947974", "pmid": "32842900", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2020-11-26T14:07:08.227Z", "modified": "2022-11-10T06:58:24.372Z"}, {"entity": "publication", "iuid": "99c39777a8b44be79113d736aaa9af74", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/99c39777a8b44be79113d736aaa9af74.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/99c39777a8b44be79113d736aaa9af74"}}, "title": "Immune responses during COVID-19 infection.", "authors": [{"family": "Melenotte", "given": "Cl\u00e9a", "initials": "C"}, {"family": "Silvin", "given": "Aymeric", "initials": "A"}, {"family": "Goubet", "given": "Anne-Ga\u00eblle", "initials": "AG"}, {"family": "Lahmar", "given": "Imran", "initials": "I"}, {"family": "Dubuisson", "given": "Agathe", "initials": "A"}, {"family": "Zumla", "given": "Alimuddin", "initials": "A"}, {"family": "Raoult", "given": "Didier", "initials": "D"}, {"family": "Merad", "given": "Mansouria", "initials": "M"}, {"family": "Gachot", "given": "Bertrand", "initials": "B"}, {"family": "H\u00e9non", "given": "Cl\u00e9mence", "initials": "C"}, {"family": "Solary", "given": "Eric", "initials": "E"}, {"family": "Fontenay", "given": "Michaela", "initials": "M"}, {"family": "Andr\u00e9", "given": "Fabrice", "initials": "F"}, {"family": "Maeurer", "given": "Markus", "initials": "M"}, {"family": "Ippolito", "given": "Giuseppe", "initials": "G"}, {"family": "Piacentini", "given": "Mauro", "initials": "M"}, {"family": "Wang", "given": "Fu-Sheng", "initials": "FS"}, {"family": "Ginhoux", "given": "Florent", "initials": "F"}, {"family": "Marabelle", "given": "Aur\u00e9lien", "initials": "A"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}, {"family": "Derosa", "given": "Lisa", "initials": "L"}, {"family": "Zitvogel", "given": "Laurence", "initials": "L"}], "type": "journal article", "published": "2020-08-25", "journal": {"title": "Oncoimmunology", "issn": "2162-4011", "volume": "9", "issue": "1", "pages": "1807836", "issn-l": null}, "abstract": "Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV (SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV) in 2012 and 2015, and SARS-CoV-2 in 2020, have been causing severe and fatal human epidemics. The unpredictability of coronavirus disease-19 (COVID-19) poses a major burden on health care and economic systems across the world. This is caused by the paucity of in-depth knowledge of the risk factors for severe COVID-19, insufficient diagnostic tools for the detection of SARS-CoV-2, as well as the absence of specific and effective drug treatments. While protective humoral and cellular immune responses are usually mounted against these betacoronaviruses, immune responses to SARS-CoV2 sometimes derail towards inflammatory tissue damage, leading to rapid admissions to intensive care units. The lack of knowledge on mechanisms that tilt the balance between these two opposite outcomes poses major threats to many ongoing clinical trials dealing with immunostimulatory or immunoregulatory therapeutics. This review will discuss innate and cognate immune responses underlying protective or deleterious immune reactions against these pathogenic coronaviruses.", "doi": "10.1080/2162402X.2020.1807836", "pmid": "32939324", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "1807836"}, {"db": "pmc", "key": "PMC7480812"}], "notes": [], "created": "2020-11-26T12:15:02.048Z", "modified": "2020-11-27T12:42:13.354Z"}, {"entity": "publication", "iuid": "fc8a52681ad84a3cb81c18e72172ee8b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc8a52681ad84a3cb81c18e72172ee8b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc8a52681ad84a3cb81c18e72172ee8b"}}, "title": "Has Sweden's controversial covid-19 strategy been successful or not?", "authors": [{"family": "Murray", "given": "John", "initials": "J"}], "type": "letter", "published": "2020-08-25", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "370", "issue": null, "pages": "m3255", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m3255", "pmid": "32843334", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-07T10:26:12.353Z", "modified": "2023-01-13T13:35:57.788Z"}, {"entity": "publication", "iuid": "9bdc4f367ba845b2be31cf156b1c4ebd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9bdc4f367ba845b2be31cf156b1c4ebd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9bdc4f367ba845b2be31cf156b1c4ebd"}}, "title": "An Ethics Framework for Making Resource Allocation Decisions Within Clinical Care: Responding to COVID-19.", "authors": [{"family": "Dawson", "given": "Angus", "initials": "A"}, {"family": "Isaacs", "given": "David", "initials": "D"}, {"family": "Jansen", "given": "Melanie", "initials": "M"}, {"family": "Jordens", "given": "Christopher", "initials": "C"}, {"family": "Kerridge", "given": "Ian", "initials": "I"}, {"family": "Kihlbom", "given": "Ulrik", "initials": "U"}, {"family": "Kilham", "given": "Henry", "initials": "H"}, {"family": "Preisz", "given": "Anne", "initials": "A"}, {"family": "Sheahan", "given": "Linda", "initials": "L"}, {"family": "Skowronski", "given": "George", "initials": "G"}], "type": "journal article", "published": "2020-08-25", "journal": {"title": "J Bioeth Inq", "issn": "1176-7529", "volume": null, "issue": null, "issn-l": null}, "abstract": "On March, 24, 2020, 818 cases of COVID-19 had been reported in New South Wales, Australia, and new cases were increasing at an exponential rate. In anticipation of resource constraints arising in clinical settings as a result of the COVID-19 pandemic, a working party of ten ethicists (seven clinicians and three full-time academics) was convened at the University of Sydney to draft an ethics framework to support resource allocation decisions. The framework guides decision-makers using a question-and-answer format, in language that avoids philosophical and medical technicality. The working party met five times over the following week and then submitted a draft Framework for consideration by two groups of intensivists and one group of academic ethicists. It was also presented to a panel on a national current affairs programme. The Framework was then revised on the basis of feedback from these sources and made publicly available online on April 3, ten days after the initial meeting. The framework is published here in full to stimulate ongoing discussion about rapid development of user-friendly clinical ethics resources in ongoing and future pandemics.", "doi": "10.1007/s11673-020-10007-w", "pmid": "32840833", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11673-020-10007-w"}, {"db": "pmc", "key": "PMC7445717"}], "notes": [], "created": "2020-12-07T10:28:14.151Z", "modified": "2020-12-07T10:28:14.173Z"}, {"entity": "publication", "iuid": "d4e822d3f5534290bc611a668851656b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4e822d3f5534290bc611a668851656b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4e822d3f5534290bc611a668851656b"}}, "title": "The burden of alcohol on health care during COVID-19.", "authors": [{"family": "Stockwell", "given": "Tim", "initials": "T"}, {"family": "Andreasson", "given": "Sven", "initials": "S"}, {"family": "Cherpitel", "given": "Cheryl", "initials": "C"}, {"family": "Chikritzhs", "given": "Tanya", "initials": "T"}, {"family": "Dangardt", "given": "Frida", "initials": "F"}, {"family": "Holder", "given": "Harold", "initials": "H"}, {"family": "Naimi", "given": "Timothy", "initials": "T"}, {"family": "Sherk", "given": "Adam", "initials": "A"}], "type": "journal article", "published": "2020-08-24", "journal": {"title": "Drug Alcohol Rev", "issn": "1465-3362", "volume": null, "issue": null, "issn-l": "0959-5236"}, "abstract": "Alcohol's impact on global health is substantial and of a similar order of magnitude to that from COVID-19. Alcohol now also poses specific concerns, such as increased risk of severe lung infections, domestic violence, child abuse, depression and suicide. Its use is unlikely to aid physical distancing or other preventative behavioural measures. Globally, alcohol contributes to 20% of injury and 11.5% of non-injury emergency room presentations. We provide some broad comparisons between alcohol-attributable and COVID-19-related hospitalisations and deaths in North America using most recent data. For example, for Canada in 2017 it was recently estimated there were 105 065 alcohol-attributable hospitalisations which represent a substantially higher rate over time than the 10 521 COVID-19 hospitalisations reported during the first 5 months of the pandemic. Despite the current importance of protecting health-care services, most governments have deemed alcohol sales to be as essential as food, fuel and pharmaceuticals. In many countries, alcohol is now more readily available and affordable than ever before, a situation global alcohol producers benefit from and have helped engineer. We argue that to protect frontline health-care services and public health more generally, it is essential that modest, evidence-based restrictions on alcohol prices, availability and marketing are introduced. In particular, we recommend increases in excise taxation coupled with minimum unit pricing to both reduce impacts on health-care services and provide much-needed revenues for governments at this critical time.", "doi": "10.1111/dar.13143", "pmid": "32835427", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7461236"}], "notes": [], "created": "2020-12-07T11:40:25.537Z", "modified": "2020-12-07T11:40:25.549Z"}, {"entity": "publication", "iuid": "5fcff184601b48c481ad4ca44cacbec0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5fcff184601b48c481ad4ca44cacbec0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5fcff184601b48c481ad4ca44cacbec0"}}, "title": "Immediate and long-term impact of the COVID-19 pandemic on delivery of surgical services", "authors": [{"family": "S\u00f8reide", "given": "K", "initials": "K", "orcid": "0000-0001-7594-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9c5655fc6aa437d91ed5cc2b4791543.json"}}, {"family": "Hallet", "given": "J", "initials": "J", "orcid": "0000-0001-5108-1072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f2eee26bb4744bec88785a9a46843a7b.json"}}, {"family": "Matthews", "given": "J B", "initials": "JB"}, {"family": "Schnitzbauer", "given": "A A", "initials": "AA"}, {"family": "Line", "given": "P D", "initials": "PD"}, {"family": "Lai", "given": "P B S", "initials": "PBS"}, {"family": "Otero", "given": "J", "initials": "J"}, {"family": "Callegaro", "given": "D", "initials": "D"}, {"family": "Warner", "given": "S G", "initials": "SG"}, {"family": "Baxter", "given": "N N", "initials": "NN"}, {"family": "Teh", "given": "C S C", "initials": "CSC"}, {"family": "Ng-Kamstra", "given": "J", "initials": "J"}, {"family": "Meara", "given": "J G", "initials": "JG"}, {"family": "Hagander", "given": "L", "initials": "L"}, {"family": "Lorenzon", "given": "L", "initials": "L", "orcid": "0000-0001-6736-0383", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2261efd5049432fa79781dece035f81.json"}}], "type": "journal-article", "published": "2020-08-24", "journal": {"title": "Br J Surg", "issn": "1365-2168", "volume": "107", "issue": "10", "pages": "1250-1261", "issn-l": null}, "abstract": "The ongoing pandemic is having a collateral health effect on delivery of surgical care to millions of patients. Very little is known about pandemic management and effects on other services, including delivery of surgery.\n\nThis was a scoping review of all available literature pertaining to COVID-19 and surgery, using electronic databases, society websites, webinars and preprint repositories.\n\nSeveral perioperative guidelines have been issued within a short time. Many suggestions are contradictory and based on anecdotal data at best. As regions with the highest volume of operations per capita are being hit, an unprecedented number of operations are being cancelled or deferred. No major stakeholder seems to have considered how a pandemic deprives patients with a surgical condition of resources, with patients disproportionally affected owing to the nature of treatment (use of anaesthesia, operating rooms, protective equipment, physical invasion and need for perioperative care). No recommendations exist regarding how to reopen surgical delivery. The postpandemic evaluation and future planning should involve surgical services as an essential part to maintain appropriate surgical care for the population during an outbreak. Surgical delivery, owing to its cross-cutting nature and synergistic effects on health systems at large, needs to be built into the WHO agenda for national health planning.\n\nPatients are being deprived of surgical access, with uncertain loss of function and risk of adverse prognosis as a collateral effect of the pandemic. Surgical services need a contingency plan for maintaining surgical care in an ongoing or postpandemic phase.", "doi": "10.1002/bjs.11670", "pmid": "32350857", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7267363"}], "notes": [], "created": "2020-11-30T15:53:12.325Z", "modified": "2021-12-06T12:58:21.582Z"}, {"entity": "publication", "iuid": "e34e09f4923d4ca98614c3edec114005", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e34e09f4923d4ca98614c3edec114005.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e34e09f4923d4ca98614c3edec114005"}}, "title": "Sex and gender: modifiers of health, disease, and medicine.", "authors": [{"family": "Mauvais-Jarvis", "given": "Franck", "initials": "F"}, {"family": "Bairey Merz", "given": "Noel", "initials": "N"}, {"family": "Barnes", "given": "Peter J", "initials": "PJ"}, {"family": "Brinton", "given": "Roberta D", "initials": "RD"}, {"family": "Carrero", "given": "Juan-Jesus", "initials": "JJ"}, {"family": "DeMeo", "given": "Dawn L", "initials": "DL"}, {"family": "De Vries", "given": "Geert J", "initials": "GJ"}, {"family": "Epperson", "given": "C Neill", "initials": "CN"}, {"family": "Govindan", "given": "Ramaswamy", "initials": "R"}, {"family": "Klein", "given": "Sabra L", "initials": "SL"}, {"family": "Lonardo", "given": "Amedeo", "initials": "A"}, {"family": "Maki", "given": "Pauline M", "initials": "PM"}, {"family": "McCullough", "given": "Louise D", "initials": "LD"}, {"family": "Regitz-Zagrosek", "given": "Vera", "initials": "V"}, {"family": "Regensteiner", "given": "Judith G", "initials": "JG"}, {"family": "Rubin", "given": "Joshua B", "initials": "JB"}, {"family": "Sandberg", "given": "Kathryn", "initials": "K"}, {"family": "Suzuki", "given": "Ayako", "initials": "A"}], "type": "journal article", "published": "2020-08-22", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "396", "issue": "10250", "pages": "565-582", "issn-l": "0140-6736"}, "abstract": "Clinicians can encounter sex and gender disparities in diagnostic and therapeutic responses. These disparities are noted in epidemiology, pathophysiology, clinical manifestations, disease progression, and response to treatment. This Review discusses the fundamental influences of sex and gender as modifiers of the major causes of death and morbidity. We articulate how the genetic, epigenetic, and hormonal influences of biological sex influence physiology and disease, and how the social constructs of gender affect the behaviour of the community, clinicians, and patients in the health-care system and interact with pathobiology. We aim to guide clinicians and researchers to consider sex and gender in their approach to diagnosis, prevention, and treatment of diseases as a necessary and fundamental step towards precision medicine, which will benefit men's and women's health.", "doi": "10.1016/S0140-6736(20)31561-0", "pmid": "32828189", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31561-0"}, {"db": "pmc", "key": "PMC7440877"}], "notes": [], "created": "2020-11-26T12:16:07.413Z", "modified": "2020-11-30T08:40:58.044Z"}, {"entity": "publication", "iuid": "9ca7de1ca24b481ab6dcc12f46bb0089", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ca7de1ca24b481ab6dcc12f46bb0089.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ca7de1ca24b481ab6dcc12f46bb0089"}}, "title": "Rapid Review of SARS-CoV-1 and SARS-CoV-2 Viability, Susceptibility to Treatment, and the Disinfection and Reuse of PPE, Particularly Filtering Facepiece Respirators.", "authors": [{"family": "Derraik", "given": "Jos\u00e9 G B", "initials": "JGB"}, {"family": "Anderson", "given": "William A", "initials": "WA"}, {"family": "Connelly", "given": "Elizabeth A", "initials": "EA"}, {"family": "Anderson", "given": "Yvonne C", "initials": "YC"}], "type": "journal article", "published": "2020-08-22", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "17", "issue": "17", "issn-l": null}, "abstract": "In the COVID-19 pandemic caused by SARS-CoV-2, hospitals are often stretched beyond capacity. There are widespread reports of dwindling supplies of personal protective equipment (PPE), particularly N95-type filtering facepiece respirators (FFRs), which are paramount to protect frontline medical/nursing staff, and to minimize further spread of the virus. We carried out a rapid review to summarize the existing literature on the viability of SARS-CoV-2, the efficacy of key potential disinfection procedures against the virus (specifically ultraviolet light and heat), and the impact of these procedures on FFR performance, material integrity, and/or fit. In light of the recent discovery of SARS-CoV-2 and limited associated research, our review also focused on the closely related SARS-CoV-1. We propose a possible whole-of-PPE disinfection solution for potential reuse that could be rapidly instituted in many health care settings, without significant investments in equipment.", "doi": "10.3390/ijerph17176117", "pmid": "32842655", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijerph17176117"}, {"db": "pmc", "key": "PMC7504573"}], "notes": [], "created": "2020-11-30T08:36:38.755Z", "modified": "2020-11-30T08:36:38.769Z"}, {"entity": "publication", "iuid": "7fd7c180f0204f0993b027f3d0d7bc81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7fd7c180f0204f0993b027f3d0d7bc81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7fd7c180f0204f0993b027f3d0d7bc81"}}, "title": "Natural killer cell immunotypes related to COVID-19 disease severity.", "authors": [{"family": "Maucourant", "given": "Christopher", "initials": "C", "orcid": "0000-0003-1033-2992", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb599f0df0bc42b88ddac10943ea3f6a.json"}}, {"family": "Filipovic", "given": "Iva", "initials": "I", "orcid": "0000-0002-8166-5500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c79974df90ae4fbf8be348b9b47d0317.json"}}, {"family": "Ponzetta", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3224-802X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8d6bca49dc24e558ca8f0b3637d7702.json"}}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Cornillet", "given": "Martin", "initials": "M", "orcid": "0000-0001-7981-0927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20d0c2fd2be843668806a91d2d83104b.json"}}, {"family": "Hertwig", "given": "Laura", "initials": "L", "orcid": "0000-0002-1170-0948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbc76f6fbe8b4fcebfa928374618b304.json"}}, {"family": "Strunz", "given": "Benedikt", "initials": "B"}, {"family": "Lentini", "given": "Antonio", "initials": "A", "orcid": "0000-0003-1239-5495", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8c1f3989ef84f6d9803fb30b3014dc4.json"}}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Brownlie", "given": "Demi", "initials": "D", "orcid": "0000-0001-5932-6425", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/099513dbc2004b41a5017db9fee6b0b3.json"}}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Ask", "given": "Eivind Heggernes", "initials": "EH", "orcid": "0000-0001-8655-1433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad160fa96dd94738a713f5c6934e61fa.json"}}, {"family": "Hull", "given": "Ryan M", "initials": "RM", "orcid": "0000-0001-7153-4198", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/957f3dfe66c6442d897faa0eb44a0975.json"}}, {"family": "Haroun-Izquierdo", "given": "Alvaro", "initials": "A", "orcid": "0000-0003-4557-3606", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb8c47d324cb44c0baf2c78e93d849d2.json"}}, {"family": "Schaffer", "given": "Marie", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Folkesson", "given": "Elin", "initials": "E", "orcid": "0000-0002-6585-6235", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a96b0fba760f4aee8e45d11b79ddf6e0.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}, {"family": "Sandberg", "given": "Johan K", "initials": "JK", "orcid": "0000-0002-6275-0750", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61225c074353413bb0b19c43b555732a.json"}}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Rooyackers", "given": "Olav", "initials": "O", "orcid": "0000-0002-3391-5448", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76700613a0f4410ab6c7d95658297e3f.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Malmberg", "given": "Karl-Johan", "initials": "KJ"}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Marquardt", "given": "Nicole", "initials": "N", "orcid": "0000-0003-3186-4752", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ac381a2857740708edf9145a7c5531c.json"}}, {"family": "Hammer", "given": "Quirin", "initials": "Q", "orcid": "0000-0003-2968-6061", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a71cf4c6d4d419daacba48ebd924238.json"}}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-8801-3169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37509c3832244b019b91a1fe2cbe183e.json"}}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4691d38f3268433696d7c65ea235a12b.json"}}, {"family": "Karolinska COVID-19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-21", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "issn-l": "2470-9468", "volume": "5", "issue": "50", "pages": null}, "abstract": "Understanding innate immune responses in COVID-19 is important to decipher mechanisms of host responses and interpret disease pathogenesis. Natural killer (NK) cells are innate effector lymphocytes that respond to acute viral infections but might also contribute to immunopathology. Using 28-color flow cytometry, we here reveal strong NK cell activation across distinct subsets in peripheral blood of COVID-19 patients. This pattern was mirrored in scRNA-seq signatures of NK cells in bronchoalveolar lavage from COVID-19 patients. Unsupervised high-dimensional analysis of peripheral blood NK cells furthermore identified distinct NK cell immunotypes that were linked to disease severity. Hallmarks of these immunotypes were high expression of perforin, NKG2C, and Ksp37, reflecting increased presence of adaptive NK cells in circulation of patients with severe disease. Finally, arming of CD56bright NK cells was observed across COVID-19 disease states, driven by a defined protein-protein interaction network of inflammatory soluble factors. This study provides a detailed map of the NK cell activation landscape in COVID-19 disease.", "doi": "10.1126/sciimmunol.abd6832", "pmid": "32826343", "labels": {"Type: Journal article": null, "Funder: VR: Special COVID-19 funding": null, "Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Diagnostics for virus": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Category: Imaging": null, "Category: Health": null, "Category: Other": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC7665314"}, {"db": "pii", "key": "5/50/eabd6832"}], "notes": [], "created": "2020-10-28T09:12:39.024Z", "modified": "2023-06-19T15:01:40.035Z"}, {"entity": "publication", "iuid": "8adf9c36ef8841da9896b05a4ca7eae2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8adf9c36ef8841da9896b05a4ca7eae2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8adf9c36ef8841da9896b05a4ca7eae2"}}, "title": "Universal Basic Income as a Policy Response to COVID-19 and Precarious Employment: Potential Impacts on Rehabilitation and Return-to-Work.", "authors": [{"family": "St\u00e5hl", "given": "Christian", "initials": "C"}, {"family": "MacEachen", "given": "Ellen", "initials": "E"}], "type": "editorial", "published": "2020-08-20", "journal": {"title": "J Occup Rehabil", "issn": "1573-3688", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1007/s10926-020-09923-w", "pmid": "32816204", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10926-020-09923-w"}, {"db": "pmc", "key": "PMC7439237"}], "notes": [], "created": "2020-12-07T12:47:13.419Z", "modified": "2020-12-07T12:47:13.439Z"}, {"entity": "publication", "iuid": "6d3514760222420687c2e3be578a7782", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6d3514760222420687c2e3be578a7782.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6d3514760222420687c2e3be578a7782"}}, "title": "Sex and age differences in COVID-19 mortality in Europe&nbsp.", "authors": [{"family": "Ahrenfeldt", "given": "Linda Juel", "initials": "LJ"}, {"family": "Otavova", "given": "Martina", "initials": "M"}, {"family": "Christensen", "given": "Kaare", "initials": "K"}, {"family": "Lindahl-Jacobsen", "given": "Rune", "initials": "R"}], "type": "preprint", "published": "2020-08-19", "journal": {"title": "Res Sq", "issn": null, "volume": null, "issue": null, "issn-l": null}, "abstract": "To examine the magnitude of sex differences in survival from the Coronavirus Disease 2019 (COVID-19) in Europe across age and countries. We hypothesise that men have higher mortality than women at any given age, but that sex differences will decrease with age as only the strongest men survive to older ages. Aim: We used population data from Institut National D'\u00c9tudes D\u00e9mographiques on cumulative deaths due to COVID-19 from February to June 2020 in 10 European countries: Denmark, Norway, Sweden, The Netherlands, England & Wales, France, Germany, Italy, Spain and Portugal. For each country, we calculated cumulative mortality rates stratified by age and sex and corresponding relative risks for men vs. women. Methods: The relative risk of dying from COVID-19 was higher for men than for women in almost all age groups in all countries. The overall relative risk ranged from 1.11 (95% CI 1.01-1.23) in Portugal to 1.54 (95% CI 1.49-1.58) in France. In most countries, sex differences increased until ages 60-69 years, but decreased thereafter with the smallest sex difference at ages 80+. Results: Despite variability in data collection and time coverage among countries, we illustrate an overall similar pattern of sex differences in COVID-19 mortality in Europe.Conclusions:", "doi": "10.21203/rs.3.rs-61444/v1", "pmid": "32839767", "labels": {"Type: Preprint": null}, "xrefs": [{"db": "pmc", "key": "PMC7444295"}], "notes": [], "created": "2020-12-07T10:29:17.011Z", "modified": "2020-12-07T10:29:17.012Z"}, {"entity": "publication", "iuid": "473564f5c7634a5aa0fac6da9882b24d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/473564f5c7634a5aa0fac6da9882b24d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/473564f5c7634a5aa0fac6da9882b24d"}}, "title": "On-target versus off-target effects of drugs inhibiting the replication of SARS-CoV-2.", "authors": [{"family": "Sauvat", "given": "Allan", "initials": "A"}, {"family": "Ciccosanti", "given": "Fabiola", "initials": "F"}, {"family": "Colavita", "given": "Francesca", "initials": "F"}, {"family": "Di Rienzo", "given": "Martina", "initials": "M"}, {"family": "Castilletti", "given": "Concetta", "initials": "C"}, {"family": "Capobianchi", "given": "Maria Rosaria", "initials": "MR"}, {"family": "Kepp", "given": "Oliver", "initials": "O"}, {"family": "Zitvogel", "given": "Laurence", "initials": "L"}, {"family": "Fimia", "given": "Gian Maria", "initials": "GM"}, {"family": "Piacentini", "given": "Mauro", "initials": "M"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}], "type": "journal article", "published": "2020-08-19", "journal": {"title": "Cell Death Dis", "issn": "2041-4889", "issn-l": null, "volume": "11", "issue": "8", "pages": "656"}, "abstract": "The current epidemic of coronavirus disease-19 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) calls for the development of inhibitors of viral replication. Here, we performed a bioinformatic analysis of published and purported SARS-CoV-2 antivirals including imatinib mesylate that we found to suppress SARS-CoV-2 replication on Vero E6 cells and that, according to the published literature on other coronaviruses is likely to act on-target, as a tyrosine kinase inhibitor. We identified a cluster of SARS-CoV-2 antivirals with characteristics of lysosomotropic agents, meaning that they are lipophilic weak bases capable of penetrating into cells. These agents include cepharentine, chloroquine, chlorpromazine, clemastine, cloperastine, emetine, hydroxychloroquine, haloperidol, ML240, PB28, ponatinib, siramesine, and zotatifin (eFT226) all of which are likely to inhibit SARS-CoV-2 replication by non-specific (off-target) effects, meaning that they probably do not act on their 'official' pharmacological targets, but rather interfere with viral replication through non-specific effects on acidophilic organelles including autophagosomes, endosomes, and lysosomes. Imatinib mesylate did not fall into this cluster. In conclusion, we propose a tentative classification of SARS-CoV-2 antivirals into specific (on-target) versus non-specific (off-target) agents based on their physicochemical characteristics.", "doi": "10.1038/s41419-020-02842-x", "pmid": "32814759", "labels": {"Type: Journal article": null, "Funder: H2020": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41419-020-02842-x"}, {"db": "pmc", "key": "PMC7434849"}], "notes": [], "created": "2020-12-07T12:48:01.042Z", "modified": "2021-02-26T08:45:25.857Z"}, {"entity": "publication", "iuid": "8800fa8905744a2ca57d7934df8aa12f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8800fa8905744a2ca57d7934df8aa12f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8800fa8905744a2ca57d7934df8aa12f"}}, "title": "Labile PT-INR in a Covid-19 Patient Under Long-term Vitamin K Antagonist Therapy: a Case Report.", "authors": [{"family": "Trevisan", "given": "Caterina", "initials": "C"}, {"family": "Miconi", "given": "Lorella", "initials": "L"}, {"family": "Barbierato", "given": "Emanuele", "initials": "E"}, {"family": "Marinaro", "given": "Giuseppe", "initials": "G"}, {"family": "Targhetta", "given": "Stefano", "initials": "S"}, {"family": "D'agata", "given": "Mario", "initials": "M"}, {"family": "Rinaldi", "given": "Daniela", "initials": "D"}], "type": "journal article", "published": "2020-08-19", "journal": {"title": "SN Compr Clin Med", "issn": "2523-8973", "volume": null, "issue": null, "pages": "1-3", "issn-l": null}, "abstract": "The COronaVIrus Disease-19 (COVID-19) has been associated with thromboembolic complications, but evidence on its impact on hemorrhagic risk are still scarce. We describe a case of COVID-19 with hemorrhagic complication in the post-acute phase of the disease. The patient was a 93-year-old woman admitted to a post-acute care unit for COVID-19 patients in northern Italy. The patient's medical history included moderate cognitive impairment, atrial fibrillation under oral anticoagulation (warfarin 2.5 mg and 3.75 mg on alternate days, showing stable PT-INR values since October 2018), and arterial hypertension. The patient was affected by COVID-19, treated with supportive therapy. In the post-acute phase of the disease, the patient presented with melena and showed a marked elevation of PT-INR of 25.1. She was treated with venous infusion of three-factor prothrombin complex concentrate and vitamin K until PT-INR reduction. After 5 days, blood analyses revealed normal hemoglobin, PT-INR 2.15, and a slight alteration of liver function. This case supports a strong impact of the infection on the coagulative pattern not only pro-thrombotically but also by increasing hemorrhagic risk. Special attention should therefore be paid to COVID-19 patients under anticoagulation with vitamin K antagonist and a shift to heparin treatment until illness resolution may be a safe option in these individuals.", "doi": "10.1007/s42399-020-00460-4", "pmid": "32839751", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "460"}, {"db": "pmc", "key": "PMC7437640"}], "notes": [], "created": "2020-12-07T10:30:37.675Z", "modified": "2021-02-26T08:45:48.432Z"}, {"entity": "publication", "iuid": "32aab714fa474fba9d9f2878a97e395d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/32aab714fa474fba9d9f2878a97e395d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/32aab714fa474fba9d9f2878a97e395d"}}, "title": "The COVID-19 Pandemic and Its Impact on Children in Domestic Violence Refuges.", "authors": [{"family": "\u00d8verlien", "given": "Carolina", "initials": "C"}], "type": "journal article", "published": "2020-08-18", "journal": {"title": "Child Abuse Rev", "issn": "1099-0852", "volume": null, "issue": null, "issn-l": null}, "abstract": "The COVID-19 pandemic has resulted in negative consequences for children exposed to violence and abuse.Domestic violence refuge staff were greatly concerned about children both living outside and inside refuges.Domestic violence refuges have played a pivotal role during the COVID-19 pandemic and should receive wider acknowledgement and greater support for their work.", "doi": "10.1002/car.2650", "pmid": "32904999", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "CAR2650"}, {"db": "pmc", "key": "PMC7461223"}], "notes": [], "created": "2020-12-03T16:14:23.593Z", "modified": "2020-12-03T16:14:23.619Z"}, {"entity": "publication", "iuid": "7da622d92e2046018ed3ea5aeb2c889a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7da622d92e2046018ed3ea5aeb2c889a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7da622d92e2046018ed3ea5aeb2c889a"}}, "title": "Nanoscale Structural Characterization of Individual Viral Particles Using Atomic Force Microscopy Infrared Spectroscopy (AFM-IR) and Tip-Enhanced Raman Spectroscopy (TERS).", "authors": [{"family": "Dou", "given": "Tianyi", "initials": "T"}, {"family": "Li", "given": "Zhandong", "initials": "Z"}, {"family": "Zhang", "given": "Junjie", "initials": "J"}, {"family": "Evilevitch", "given": "Alex", "initials": "A"}, {"family": "Kurouski", "given": "Dmitry", "initials": "D"}], "type": "journal article", "published": "2020-08-18", "journal": {"title": "Anal Chem", "issn": "1520-6882", "volume": "92", "issue": "16", "pages": "11297-11304", "issn-l": null}, "abstract": "Viruses are infections species that infect a large spectrum of living systems. Although displaying a wide variety of shapes and sizes, they are all composed of nucleic acid encapsulated into a protein capsid. After virions enter the host cell, they replicate to produce multiple copies of themselves. They then lyse the host, releasing virions to infect new cells. The high proliferation rate of viruses is the underlying cause of their fast transmission among living species. Although many viruses are harmless, some of them are responsible for severe diseases such as AIDS, viral hepatitis, and flu. Traditionally, electron microscopy is used to identify and characterize viruses. This approach is time- and labor-consuming, which is problematic upon pandemic proliferation of previously unknown viruses, such as H1N1 and COVID-19. Herein, we demonstrate a novel diagnosis approach for label-free identification and structural characterization of individual viruses that is based on a combination of nanoscale Raman and infrared spectroscopy. Using atomic force microscopy-infrared (AFM-IR) spectroscopy, we were able to probe structural organization of the virions of Herpes Simplex Type 1 viruses and bacteriophage MS2. We also showed that tip-enhanced Raman spectroscopy (TERS) could be used to reveal protein secondary structure and amino acid composition of the virus surface. Our results show that AFM-IR and TERS provide different but complementary information about the structure of complex biological specimens. This structural information can be used for fast and reliable identification of viruses. This nanoscale bimodal imaging approach can be also used to investigate the origin of viral polymorphism and study mechanisms of virion assembly.", "doi": "10.1021/acs.analchem.0c01971", "pmid": "32683857", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-07T16:31:16.731Z", "modified": "2021-02-26T08:46:13.317Z"}, {"entity": "publication", "iuid": "6cb1c940d5e1434493243bf243fe4e1b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6cb1c940d5e1434493243bf243fe4e1b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6cb1c940d5e1434493243bf243fe4e1b"}}, "title": "Hyperinflammation and Fibrosis in Severe COVID-19 Patients: Galectin-3, a Target Molecule to Consider.", "authors": [{"family": "Garcia-Revilla", "given": "Juan", "initials": "J"}, {"family": "Deierborg", "given": "Tomas", "initials": "T"}, {"family": "Venero", "given": "Jose Luis", "initials": "JL"}, {"family": "Boza-Serrano", "given": "Antonio", "initials": "A"}], "type": "journal article", "published": "2020-08-18", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "11", "issue": null, "pages": "2069"}, "abstract": "COVID-19 disease have become so far the most important sanitary crisis in the XXI century. In light of the events, any clinical resource should be considered to alleviate this crisis. Severe COVID-19 cases present a so-called cytokine storm as the most life-threatening symptom accompanied by lung fibrosis. Galectin-3 has been widely described as regulator of both processes. Hereby, we present compelling evidences on the potential role of galectin-3 in COVID-19 in the regulation of the inflammatory response, fibrosis and infection progression. Moreover, we provide a strong rationale of the utility of measuring plasma galectin-3 as a prognosis biomarker for COVID-19 patients and propose that inhibition of galectin-3 represents a feasible and promising new therapeutical approach.", "doi": "10.3389/fimmu.2020.02069", "pmid": "32973815", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7461806"}], "notes": [], "created": "2020-12-03T14:47:58.464Z", "modified": "2021-02-26T08:45:48.289Z"}, {"entity": "publication", "iuid": "02e13799c10c47cfbba71fec75ea0714", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02e13799c10c47cfbba71fec75ea0714.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02e13799c10c47cfbba71fec75ea0714"}}, "title": "A picture of medically assisted reproduction activities during the COVID-19 pandemic in Europe.", "authors": [{"family": "ESHRE COVID-19 Working Group ", "given": "", "initials": ""}, {"family": "Vermeulen", "given": "Nathalie", "initials": "N"}, {"family": "Ata", "given": "Baris", "initials": "B"}, {"family": "Gianaroli", "given": "Luca", "initials": "L"}, {"family": "Lundin", "given": "Kersti", "initials": "K"}, {"family": "Mocanu", "given": "Edgar", "initials": "E"}, {"family": "Rautakallio-Hokkanen", "given": "Satu", "initials": "S"}, {"family": "Tapanainen", "given": "Juha S", "initials": "JS"}, {"family": "Veiga", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2020-08-17", "journal": {"title": "Hum Reprod Open", "issn": "2399-3529", "volume": "2020", "issue": "3", "pages": "hoaa035", "issn-l": null}, "abstract": "How did coronavirus disease 2019 (COVID-19) impact on medically assisted reproduction (MAR) services in Europe during the COVID-19 pandemic (March to May 2020)?\n\nMAR services, and hence treatments for infertile couples, were stopped in most European countries for a mean of 7 weeks.\n\nWith the outbreak of COVID-19 in Europe, non-urgent medical care was reduced by local authorities to preserve health resources and maintain social distancing. Furthermore, ESHRE and other societies recommended to postpone ART pregnancies as of 14 March 2020.\n\nA structured questionnaire was distributed in April among the ESHRE Committee of National Representatives, followed by further information collection through email.\n\nThe information was collected through the questionnaire and afterwards summarised and aligned with data from the European Centre for Disease Control on the number of COVID-19 cases per country.\n\nBy aligning the data for each country with respective epidemiological data, we show a large variation in the time and the phase in the epidemic in the curve when MAR/ART treatments were suspended and restarted. Similarly, the duration of interruption varied. Fertility preservation treatments and patient supportive care for patients remained available during the pandemic.\n\nN/A.\n\nData collection was prone to misinterpretation of the questions and replies, and required further follow-up to check the accuracy. Some representatives reported that they, themselves, were not always aware of the situation throughout the country or reported difficulties with providing single generalised replies, for instance when there were regional differences within their country.\n\nThe current article provides a basis for further research of the different strategies developed in response to the COVID-19 crisis. Such conclusions will be invaluable for health authorities and healthcare professionals with respect to future similar situations.\n\nThere was no funding for the study, apart from technical support from ESHRE. The authors had no COI to disclose.", "doi": "10.1093/hropen/hoaa035", "pmid": "32821857", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "hoaa035"}, {"db": "pmc", "key": "PMC7430925"}], "notes": [], "created": "2020-12-07T12:20:35.064Z", "modified": "2020-12-07T12:20:35.086Z"}, {"entity": "publication", "iuid": "0c7d3bc6eeb44d1ca499293fdc7c0606", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c7d3bc6eeb44d1ca499293fdc7c0606.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c7d3bc6eeb44d1ca499293fdc7c0606"}}, "title": "Treatment of COVID-19 by Inhaled NO to Reduce Shunt?", "authors": [{"family": "Hedenstierna", "given": "G\u00f6ran", "initials": "G"}, {"family": "Chen", "given": "Luni", "initials": "L"}, {"family": "Hedenstierna", "given": "Magnus", "initials": "M"}, {"family": "Scaramuzzo", "given": "Gaetano", "initials": "G"}], "type": "letter", "published": "2020-08-15", "journal": {"title": "Am J Respir Crit Care Med", "issn": "1535-4970", "volume": "202", "issue": "4", "pages": "618", "issn-l": "1073-449X"}, "abstract": null, "doi": "10.1164/rccm.202004-0940LE", "pmid": "32579020", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7427390"}], "notes": [], "created": "2020-11-22T08:37:07.315Z", "modified": "2021-02-26T08:46:12.908Z"}, {"entity": "publication", "iuid": "86e22203b5eb4143a5423f1e195fd35d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86e22203b5eb4143a5423f1e195fd35d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86e22203b5eb4143a5423f1e195fd35d"}}, "title": "Untapped resources for medical research.", "authors": [{"family": "P\u00e9rez-Escobar", "given": "Oscar A", "initials": "OA"}, {"family": "Richardson", "given": "James E", "initials": "JE"}, {"family": "Howes", "given": "Melanie-Jayne R", "initials": "MR"}, {"family": "Lucas", "given": "Eve", "initials": "E"}, {"family": "\u00c1lvarez de R\u00f3man", "given": "Noelia", "initials": "N"}, {"family": "Collemare", "given": "J\u00e9r\u00f4me", "initials": "J"}, {"family": "Graham", "given": "Ian A", "initials": "IA"}, {"family": "Gratzfeld", "given": "Joachim", "initials": "J"}, {"family": "Kersey", "given": "Paul J", "initials": "PJ"}, {"family": "Leitch", "given": "Ilia J", "initials": "IJ"}, {"family": "Paton", "given": "Alan", "initials": "A"}, {"family": "Hollingsworth", "given": "Peter M", "initials": "PM"}, {"family": "Antonelli", "given": "Alexandre", "initials": "A"}], "type": "letter", "published": "2020-08-14", "journal": {"title": "Science", "issn": "1095-9203", "volume": "369", "issue": "6505", "pages": "781-782", "issn-l": "0036-8075"}, "abstract": null, "doi": "10.1126/science.abc8085", "pmid": "32792391", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "369/6505/781"}], "notes": [], "created": "2020-12-07T13:24:59.238Z", "modified": "2020-12-07T13:24:59.247Z"}, {"entity": "publication", "iuid": "d86a1fd91cdf4b48a66560ce4eea9a30", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d86a1fd91cdf4b48a66560ce4eea9a30.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d86a1fd91cdf4b48a66560ce4eea9a30"}}, "title": "A mathematical model reveals the influence of population heterogeneity on herd immunity to SARS-CoV-2.", "authors": [{"family": "Britton", "given": "Tom", "initials": "T", "orcid": "0000-0002-9228-7357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3953e83bbffb428ab0a02f335979acb2.json"}}, {"family": "Ball", "given": "Frank", "initials": "F", "orcid": "0000-0002-5599-2903", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a08214bb29404f58b5286d6d1368b3e4.json"}}, {"family": "Trapman", "given": "Pieter", "initials": "P", "orcid": "0000-0003-0569-1659", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a2df9c9216143cd8219de8687414709.json"}}], "type": "journal article", "published": "2020-08-14", "journal": {"title": "Science", "issn": "1095-9203", "issn-l": "0036-8075", "volume": "369", "issue": "6505", "pages": "846-849"}, "abstract": "Despite various levels of preventive measures, in 2020, many countries have suffered severely from the coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Using a model, we show that population heterogeneity can affect disease-induced immunity considerably because the proportion of infected individuals in groups with the highest contact rates is greater than that in groups with low contact rates. We estimate that if R 0 = 2.5 in an age-structured community with mixing rates fitted to social activity, then the disease-induced herd immunity level can be ~43%, which is substantially less than the classical herd immunity level of 60% obtained through homogeneous immunization of the population. Our estimates should be interpreted as an illustration of how population heterogeneity affects herd immunity rather than as an exact value or even a best estimate.", "doi": "10.1126/science.abc6810", "pmid": "32576668", "labels": {"Funder: VR: Special COVID-19 funding": null, "Type: Journal article": null, "Funder: VR": null, "Funder: NordForsk": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7331793"}, {"db": "pii", "key": "science.abc6810"}], "notes": [], "created": "2020-12-04T09:13:31.584Z", "modified": "2023-06-19T15:26:16.461Z"}, {"entity": "publication", "iuid": "c17d5d63db7a4237b23fb9c1bfdf17fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c17d5d63db7a4237b23fb9c1bfdf17fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c17d5d63db7a4237b23fb9c1bfdf17fc"}}, "title": "Mismatch between circulating cytokines and spontaneous cytokine production by leukocytes in hyperinflammatory COVID-19.", "authors": [{"family": "Kahn", "given": "Robin", "initials": "R"}, {"family": "Schmidt", "given": "Tobias", "initials": "T"}, {"family": "Golestani", "given": "Karan", "initials": "K"}, {"family": "Mossberg", "given": "Anki", "initials": "A"}, {"family": "Gullstrand", "given": "Birgitta", "initials": "B"}, {"family": "Bengtsson", "given": "Anders A", "initials": "AA"}, {"family": "Kahn", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2020-08-13", "journal": {"title": "J Leukoc Biol", "issn": "1938-3673", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The disease COVID-19 has developed into a worldwide pandemic. Hyperinflammation and high levels of several cytokines, for example, IL-6, are observed in severe COVID-19 cases. However, little is known about the cellular origin of these cytokines. Here, we investigated whether circulating leukocytes from patients with COVID-19 had spontaneous cytokine production. Patients with hyperinflammatory COVID-19 (n = 6) and sepsis (n = 3) were included at Sk\u00e5ne University Hospital, Sweden. Healthy controls were also recruited (n = 5). Cytokines were measured in COVID-19 and sepsis patients using an Immulite immunoassay system. PBMCs were cultured with brefeldin A to allow cytokine accumulation. In parallel, LPS was used as an activator. Cells were analyzed for cytokines and surface markers by flow cytometry. High levels of IL-6 and measurable levels of IL-8 and TNF, but not IL-1\u03b2, were observed in COVID-19 patients. Monocytes from COVID-19 patients had spontaneous production of IL-1\u03b2 and IL-8 (P = 0.0043), but not of TNF and IL-6, compared to controls. No spontaneous cytokine production was seen in lymphocytes from either patients or controls. Activation with LPS resulted in massive cytokine production by monocytes from COVID-19 patients and healthy controls, but not from sepsis patients. Finally, monocytes from COVID-19 patients produced more IL-1\u03b2 than from healthy controls (P = 0.0087) when activated. In conclusion, monocytes contribute partly to the ongoing hyperinflammation by production of IL-1\u03b2 and IL-8. Additionally, they are responsive to further activation. This data supports the notion of IL-1\u03b2 blockade in treatment of COVID-19. However, the source of the high levels of IL-6 remains to be determined.", "doi": "10.1002/JLB.5COVBCR0720-310RR", "pmid": "32794348", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7436862"}], "notes": [], "created": "2020-12-07T13:23:36.003Z", "modified": "2021-02-26T08:45:48.663Z"}, {"entity": "publication", "iuid": "cc3dfab3c1e149f682adb6e8c95794e5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc3dfab3c1e149f682adb6e8c95794e5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc3dfab3c1e149f682adb6e8c95794e5"}}, "title": "Does Self-isolation Violate the Right to Liberty? An Analysis of the European Court of Human Rights' Practice in Light of the Ukrainian Experience.", "authors": [{"family": "Litins'ka", "given": "Yana", "initials": "Y"}, {"family": "Karpenko", "given": "Oleksandra", "initials": "O"}], "type": "journal article", "published": "2020-08-13", "journal": {"title": "Eur J Health Law", "issn": "1571-8093", "issn-l": null, "volume": "27", "issue": "4", "pages": "368-385"}, "abstract": "COVID-19 became a stress-test for many legal systems because it required that a balance be found between rapid action to prevent the spread of the disease, and continued respect for human rights. Many states in Europe, including Ukraine, chose to enforce an obligation to self-isolate. In this article we review what the obligation to self-isolate entails in the case of Ukraine. We also analyse whether such an obligation should be viewed as a deprivation or a mere restriction of liberty, and if it is permissible under the European Convention for the Protection of Human Rights and Fundamental Freedoms.", "doi": "10.1163/15718093-BJA10024", "pmid": "33652392", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-03-03T17:02:20.206Z", "modified": "2022-11-10T07:09:04.422Z"}, {"entity": "publication", "iuid": "57f235418d50452785b82c709625d36a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/57f235418d50452785b82c709625d36a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/57f235418d50452785b82c709625d36a"}}, "title": "Key questions for modelling COVID-19 exit strategies.", "authors": [{"family": "Thompson", "given": "Robin N", "initials": "RN", "orcid": "0000-0001-8545-5212", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/463364e1efea442ca7c3c0964b5b7c88.json"}}, {"family": "Hollingsworth", "given": "T D\u00e9irdre", "initials": "TD", "orcid": "0000-0001-5962-4238", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d01e91cbf744ad4aa5c10b36df42255.json"}}, {"family": "Isham", "given": "Valerie", "initials": "V"}, {"family": "Arribas-Bel", "given": "Daniel", "initials": "D"}, {"family": "Ashby", "given": "Ben", "initials": "B", "orcid": "0000-0001-5588-7081", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e962d6776bb64ff6bd6d7a776c7323dd.json"}}, {"family": "Britton", "given": "Tom", "initials": "T"}, {"family": "Challenor", "given": "Peter", "initials": "P", "orcid": "0000-0001-8661-2718", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b5d358c6c484ede8d2d1b95c69b3281.json"}}, {"family": "Chappell", "given": "Lauren H K", "initials": "LHK"}, {"family": "Clapham", "given": "Hannah", "initials": "H"}, {"family": "Cunniffe", "given": "Nik J", "initials": "NJ", "orcid": "0000-0002-3533-8672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f49041a1dab140f1ab8ed5c8b9c0d502.json"}}, {"family": "Dawid", "given": "A Philip", "initials": "AP", "orcid": "0000-0002-7410-6882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc052cc3ab66498e9d301c0508504f51.json"}}, {"family": "Donnelly", "given": "Christl A", "initials": "CA"}, {"family": "Eggo", "given": "Rosalind M", "initials": "RM", "orcid": "0000-0002-0362-6717", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f186dc5f7947456bb8ff489e19247592.json"}}, {"family": "Funk", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-2842-3406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f03dcbc41884648a4eac5892852899a.json"}}, {"family": "Gilbert", "given": "Nigel", "initials": "N", "orcid": "0000-0002-5937-2410", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b438f3904e94df3be0a7371d0c5fb0a.json"}}, {"family": "Glendinning", "given": "Paul", "initials": "P"}, {"family": "Gog", "given": "Julia R", "initials": "JR"}, {"family": "Hart", "given": "William S", "initials": "WS", "orcid": "0000-0002-2504-6860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35cc023f28a04e0b855d98ae0f6e6e12.json"}}, {"family": "Heesterbeek", "given": "Hans", "initials": "H"}, {"family": "House", "given": "Thomas", "initials": "T", "orcid": "0000-0001-5835-8062", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48eb00c619034823b5ffce15e341d79a.json"}}, {"family": "Keeling", "given": "Matt", "initials": "M", "orcid": "0000-0003-4639-4765", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f72880a3fc6a42828e1fefe724ea3d6d.json"}}, {"family": "Kiss", "given": "Istv\u00e1n Z", "initials": "IZ", "orcid": "0000-0003-1473-6644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2489413352f4748aa22dca0e980868f.json"}}, {"family": "Kretzschmar", "given": "Mirjam E", "initials": "ME"}, {"family": "Lloyd", "given": "Alun L", "initials": "AL", "orcid": "0000-0002-6389-6321", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b29752d31364120a4078e5222a33014.json"}}, {"family": "McBryde", "given": "Emma S", "initials": "ES"}, {"family": "McCaw", "given": "James M", "initials": "JM", "orcid": "0000-0002-2452-3098", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05468ff8cc244c989ddbb22d60028a48.json"}}, {"family": "McKinley", "given": "Trevelyan J", "initials": "TJ"}, {"family": "Miller", "given": "Joel C", "initials": "JC"}, {"family": "Morris", "given": "Martina", "initials": "M"}, {"family": "O'Neill", "given": "Philip D", "initials": "PD"}, {"family": "Parag", "given": "Kris V", "initials": "KV"}, {"family": "Pearson", "given": "Carl A B", "initials": "CAB", "orcid": "0000-0003-0701-7860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37a6ce9807dd405ba6480a80965ab6d2.json"}}, {"family": "Pellis", "given": "Lorenzo", "initials": "L"}, {"family": "Pulliam", "given": "Juliet R C", "initials": "JRC"}, {"family": "Ross", "given": "Joshua V", "initials": "JV", "orcid": "0000-0002-9918-8167", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15a5af493f004550bd0d431de09d7c1b.json"}}, {"family": "Tomba", "given": "Gianpaolo Scalia", "initials": "GS"}, {"family": "Silverman", "given": "Bernard W", "initials": "BW", "orcid": "0000-0002-4059-2376", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec963dc6df3d4fb68a842a7fde234aa2.json"}}, {"family": "Struchiner", "given": "Claudio J", "initials": "CJ"}, {"family": "Tildesley", "given": "Michael J", "initials": "MJ"}, {"family": "Trapman", "given": "Pieter", "initials": "P", "orcid": "0000-0003-0569-1659", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a2df9c9216143cd8219de8687414709.json"}}, {"family": "Webb", "given": "Cerian R", "initials": "CR"}, {"family": "Mollison", "given": "Denis", "initials": "D"}, {"family": "Restif", "given": "Olivier", "initials": "O", "orcid": "0000-0001-9158-853X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b62d897d36b42ba8bd57590d68d2899.json"}}], "type": "journal article", "published": "2020-08-12", "journal": {"title": "Proc Biol Sci", "issn": "1471-2954", "issn-l": null, "volume": "287", "issue": "1932", "pages": "20201405"}, "abstract": "Combinations of intense non-pharmaceutical interventions (lockdowns) were introduced worldwide to reduce SARS-CoV-2 transmission. Many governments have begun to implement exit strategies that relax restrictions while attempting to control the risk of a surge in cases. Mathematical modelling has played a central role in guiding interventions, but the challenge of designing optimal exit strategies in the face of ongoing transmission is unprecedented. Here, we report discussions from the Isaac Newton Institute 'Models for an exit strategy' workshop (11-15 May 2020). A diverse community of modellers who are providing evidence to governments worldwide were asked to identify the main questions that, if answered, would allow for more accurate predictions of the effects of different exit strategies. Based on these questions, we propose a roadmap to facilitate the development of reliable models to guide exit strategies. This roadmap requires a global collaborative effort from the scientific community and policymakers, and has three parts: (i) improve estimation of key epidemiological parameters; (ii) understand sources of heterogeneity in populations; and (iii) focus on requirements for data collection, particularly in low-to-middle-income countries. This will provide important information for planning exit strategies that balance socio-economic benefits with public health.", "doi": "10.1098/rspb.2020.1405", "pmid": "32781946", "labels": {"Type: Review": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC7575516"}], "notes": [], "created": "2020-11-30T08:41:04.303Z", "modified": "2023-06-19T15:26:28.252Z"}, {"entity": "publication", "iuid": "7bf0541d70e84f2da1fffa80763585ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7bf0541d70e84f2da1fffa80763585ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7bf0541d70e84f2da1fffa80763585ff"}}, "title": "Does the Prosperity of a Country Play a Role in COVID-19 Outcomes?", "authors": [{"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}, {"family": "Carlstr\u00f6m", "given": "Eric", "initials": "E"}, {"family": "Hertelendy", "given": "Attila J", "initials": "AJ"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}, {"family": "Casady", "given": "Carter B", "initials": "CB"}, {"family": "Burkle", "given": "Frederick M", "initials": "FM"}], "type": "journal article", "published": "2020-08-12", "journal": {"title": "Disaster Med Public Health Prep", "issn": "1938-744X", "issn-l": "1935-7893", "volume": null, "issue": null, "pages": "1-10"}, "abstract": "This study aims to clarify the association between prosperity and the coronavirus disease (COVID-19) outcomes and its impact on the future management of pandemics.\r\n\r\nThis is an observational study using information from 2 online registries. The numbers of infected individuals and deaths and the prosperity rank of each country were obtained from worldometer.info and the Legatum Institute's Prosperity Index, respectively.\r\n\r\nThere is a combination of countries with high and low prosperity on the list of COVID-19-infected countries. The risk of the virus pandemic seems to be more extensive in countries with high prosperity. A Spearman's rho test confirmed a significant correlation between prosperity, the number of COVID-19 cases, and the number of deaths at the 99% level.\r\n\r\nNew emerging pandemics affect all nations. In order to increase the likelihood of successfully managing future events, it is important to consider preexisting health security, valid population-based management approaches, medical decision-making, communication, continuous assessment, triage, treatment, early and complete physical distancing strategies, and logistics. These elements cannot be taught on-site and on occasion. There is a need for innovative and regular educational activities for all stakeholders committed to safeguarding our future defense systems concerning diagnostic, protection, treatment, and rehabilitation in pandemics, as well as other emergencies.", "doi": "10.1017/dmp.2020.304", "pmid": "32782059", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S1935789320003043"}, {"db": "pmc", "key": "PMC7477401"}], "notes": [], "created": "2020-12-07T13:29:22.810Z", "modified": "2022-11-10T07:09:49.459Z"}, {"entity": "publication", "iuid": "f232eaf8e0594f659f7ff3d2ea8bf32a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f232eaf8e0594f659f7ff3d2ea8bf32a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f232eaf8e0594f659f7ff3d2ea8bf32a"}}, "title": "Pronounced difference in Covid-19 antibody prevalence indicates cluster transmission in Stockholm, Sweden.", "authors": [{"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Hanson", "given": "Stefan", "initials": "S"}, {"family": "Olsen", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2020-08-11", "journal": {"title": "Infect Ecol Epidemiol", "issn": "2000-8686", "issn-l": "2000-8686", "volume": "10", "issue": "1", "pages": "1806505"}, "abstract": "The prevalence of COVID-19 antibodies on June 17-18, 2020 was investigated in two residential areas of Stockholm, Sweden. Among the residents in Norra Djurg\u00e5rdsstaden, a newly built upper- and middle-class area of Stockholm, 4.1% of study participants had SARS-CoV-2-specific antibodies, while in Tensta, a highly segregated low-income area, 30% of the participants tested antibody positive.", "doi": "10.1080/20008686.2020.1806505", "pmid": "32944166", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "1806505"}, {"db": "pmc", "key": "PMC7480443"}], "notes": [], "created": "2020-11-11T07:20:08.508Z", "modified": "2021-02-26T08:45:14.498Z"}, {"entity": "publication", "iuid": "420ece91e6c44fd8b90a235a80a7e4d3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/420ece91e6c44fd8b90a235a80a7e4d3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/420ece91e6c44fd8b90a235a80a7e4d3"}}, "title": "Obesity as a contributor to immunopathology in pregnant and non-pregnant adults with COVID-19.", "authors": [{"family": "McCartney", "given": "Stephen A", "initials": "SA"}, {"family": "Kachikis", "given": "Alisa", "initials": "A"}, {"family": "Huebner", "given": "Emily M", "initials": "EM"}, {"family": "Walker", "given": "Christie L", "initials": "CL"}, {"family": "Chandrasekaran", "given": "Suchi", "initials": "S"}, {"family": "Adams Waldorf", "given": "Kristina M", "initials": "KM"}], "type": "journal article", "published": "2020-08-11", "journal": {"title": "Am J Reprod Immunol", "issn": "1600-0897", "volume": null, "issue": null, "pages": "e13320", "issn-l": null}, "abstract": "The ongoing coronavirus disease 2019 (COVID-19) pandemic has led to a global public health emergency with the need to identify vulnerable populations who may benefit from increased screening and healthcare resources. Initial data suggest that overall, pregnancy is not a significant risk factor for severe coronavirus disease 2019 (COVID-19). However, case series have suggested that maternal obesity is one of the most important comorbidities associated with more severe disease. In obese individuals, suppressors of cytokine signaling are upregulated and type I and III interferon responses are delayed and blunted leading to ineffective viral clearance. Obesity is also associated with changes in systemic immunity involving a wide range of immune cells and mechanisms that lead to low-grade chronic inflammation, which can compromise antiviral immunity. Macrophage activation in adipose tissue can produce low levels of pro-inflammatory cytokines (TNF-\u03b1, IL-1\u03b2, IL-6). Further, adipocyte secretion of leptin is pro-inflammatory and high circulating levels of leptin have been associated with mortality in patients with acute respiratory distress syndrome. The synergistic effects of obesity-associated delays in immune control of COVID-19 with mechanical stress of increased adipose tissue may contribute to a greater risk of pulmonary compromise in obese pregnant women. In this review, we bring together data regarding obesity as a key co-morbidity for COVID-19 in pregnancy with known changes in the antiviral immune response associated with obesity. We also describe how the global burden of obesity among reproductive age women has serious public health implications for COVID-19.", "doi": "10.1111/aji.13320", "pmid": "32779790", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7435524"}], "notes": [], "created": "2020-11-30T08:41:05.562Z", "modified": "2020-11-30T08:41:05.587Z"}, {"entity": "publication", "iuid": "0e58ba01cbcf49a091eabdf7e0ffa9c1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e58ba01cbcf49a091eabdf7e0ffa9c1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e58ba01cbcf49a091eabdf7e0ffa9c1"}}, "title": "Laparoscopic Surgery and the debate on its safety during COVID-19 pandemic: A systematic review of recommendations.", "authors": [{"family": "El Boghdady", "given": "Michael", "initials": "M"}, {"family": "Ewalds-Kvist", "given": "Beatrice Marianne", "initials": "BM"}], "type": "journal article", "published": "2020-08-11", "journal": {"title": "Surgeon", "issn": "1479-666X", "volume": null, "issue": null, "issn-l": null}, "abstract": "The transmission of COVID-19 virus since the outbreak of viral pneumonia due to SARS-CoV-2 gave rise to protective operative measures. Aerosol generating procedures such as laparoscopic surgery are known to be associated with increased risks of viral transmission to the healthcare workers. The safety of laparoscopy during the pandemic was then debated. We aimed to systematically review the literature regarding the safe use of laparoscopy during COVID-19.\n\nWe performed a systematic search using PubMed and ScienceDirect databases from inception to 1st May, 2020. The following search terms were used: ''laparoscopic surgery and COVID-19''; ''minimally invasive surgery and COVID-19''. Search items were considered from the nature of the articles, date of publication, aims and findings in relation to use of laparoscopic surgery during COVID-19. The study protocol was registered with PROSPERO register for systematic reviews (CRD42020183432).\n\nAltogether, 174 relevant citations were identified and reviewed for this study, of which 22 articles were included. The analysis of the findings in relation to laparoscopic surgery during the pandemic were presented in tabular form. We completed the common recommendations for performing laparoscopy during the COVID-19 pandemic in forms of pre-, intra- and postoperative phases.\n\nThere is no scientific evidence to date for the transmission of COVID-19 by laparoscopic surgery. Laparoscopy can be used with precautions because of its benefits compared to open surgery. If safe, conservative management is the primary alternative during the pandemic. We concluded that recommended precautions should be respected while performing laparoscopy during the pandemic.", "doi": "10.1016/j.surge.2020.07.005", "pmid": "32855070", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1479-666X(20)30104-9"}, {"db": "pmc", "key": "PMC7418789"}], "notes": [], "created": "2020-11-30T08:36:34.178Z", "modified": "2020-11-30T08:36:34.199Z"}, {"entity": "publication", "iuid": "50dc122d0f144aa1b9ccd32a5da53091", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50dc122d0f144aa1b9ccd32a5da53091.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50dc122d0f144aa1b9ccd32a5da53091"}}, "title": "Comprehensive Overview on Multiple Strategies Fighting COVID-19.", "authors": [{"family": "Khalifa", "given": "Shaden A M", "initials": "SAM"}, {"family": "Mohamed", "given": "Briksam S", "initials": "BS"}, {"family": "Elashal", "given": "Mohamed H", "initials": "MH"}, {"family": "Du", "given": "Ming", "initials": "M"}, {"family": "Guo", "given": "Zhiming", "initials": "Z"}, {"family": "Zhao", "given": "Chao", "initials": "C"}, {"family": "Musharraf", "given": "Syed Ghulam", "initials": "SG"}, {"family": "Boskabady", "given": "Mohammad H", "initials": "MH"}, {"family": "El-Seedi", "given": "Haged H R", "initials": "HHR"}, {"family": "Efferth", "given": "Thomas", "initials": "T"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}], "type": "journal article", "published": "2020-08-11", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "17", "issue": "16", "issn-l": null}, "abstract": "Lately, myriad of novel viruses have emerged causing epidemics such as SARS, MERS, and SARS-CoV-2, leading to high mortality rates worldwide. Thus, these viruses represented a challenging threat to mankind, especially considering the miniscule data available at our disposal regarding these novel viruses. The entire world established coordinative relations in research projects regarding drug and vaccine development on the external range, whereas on the internal range, all countries declared it an emergency case through imposing different restrictions related to their border control, large gatherings, school attendance, and most social activities. Pandemic combating plans prioritized all sectors including normal people, medical staff politicians, and scientists collectively shouldered the burden. Through planning and learning the previous lessons from SARS and MERS, healthcare systems could succeed in combating the viral spread and implications of these new pandemics. Different management strategies including social distance, social awareness and isolation represented successful ways to slow down the spread of the pandemic. Furthermore, pre-preparedness of some countries for emergencies is crucial to minimize the consequences of the crisis.", "doi": "10.3390/ijerph17165813", "pmid": "32796733", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijerph17165813"}, {"db": "pmc", "key": "PMC7460286"}], "notes": [], "created": "2020-11-30T08:41:00.511Z", "modified": "2020-11-30T08:41:00.525Z"}, {"entity": "publication", "iuid": "1e17e4cbd29741e2aa6ca44f3c385dab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1e17e4cbd29741e2aa6ca44f3c385dab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1e17e4cbd29741e2aa6ca44f3c385dab"}}, "title": "Children's Anxiety and Factors Related to the COVID-19 Pandemic: An Exploratory Study Using the Children's Anxiety Questionnaire and the Numerical Rating Scale.", "authors": [{"family": "Garcia de Avila", "given": "Marla Andr\u00e9ia", "initials": "MA"}, {"family": "Hamamoto Filho", "given": "Pedro Tadao", "initials": "PT"}, {"family": "Jacob", "given": "Francine Let\u00edcia da Silva", "initials": "FLdS"}, {"family": "Alcantara", "given": "L\u00e9ia Regina Souza", "initials": "LRS"}, {"family": "Berghammer", "given": "Malin", "initials": "M"}, {"family": "Jenholt Nolbris", "given": "Margaretha", "initials": "M"}, {"family": "Olaya-Contreras", "given": "Patricia", "initials": "P"}, {"family": "Nilsson", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2020-08-09", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "16", "pages": null}, "abstract": "The repercussions of the COVID-19 pandemic on children's lives deserve attention. This study aimed to assess the prevalence of anxiety among Brazilian children and its associated factors during social distancing during COVID-19. We used a cross-sectional design with an online survey from April to May 2020 in Brazil. We included children aged 6-12 years and their guardians. The Children's Anxiety Questionnaire (CAQ; scores 4-12) and the Numerical Rating Scale (NRS; scores 0-10) were used to measure anxiety. We enrolled 157 girls and 132 boys, with a mean age of 8.84 (\u00b12.05) years; 88.9% of respondents were mothers. Based on CAQ \u2265 9, the prevalence of anxiety was 19.4% (n = 56), and higher among children with parents with essential jobs and those who were social distancing without parents. In logistic regression, the following variables were associated with higher CAQ scores: social distancing without parents; more persons living together in home; and education level of guardians. Based on NRS > 7, the prevalence of anxiety was 21.8% (n = 63); however, no associations with NRS scores were found with the investigated variables. These findings suggest the necessity of implementing public health actions targeting these parents and their children at the population level.", "doi": "10.3390/ijerph17165757", "pmid": "32784898", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "ijerph17165757"}, {"db": "pmc", "key": "PMC7459447"}], "notes": [], "created": "2020-12-07T13:28:53.440Z", "modified": "2022-11-10T07:11:07.153Z"}, {"entity": "publication", "iuid": "a94013a0dc4a4d148aa66becf6e8a548", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a94013a0dc4a4d148aa66becf6e8a548.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a94013a0dc4a4d148aa66becf6e8a548"}}, "title": "Symptoms of burnout in intensive care unit specialists facing the COVID-19 outbreak.", "authors": [{"family": "Azoulay", "given": "Elie", "initials": "E"}, {"family": "De Waele", "given": "Jan", "initials": "J"}, {"family": "Ferrer", "given": "Ricard", "initials": "R"}, {"family": "Staudinger", "given": "Thomas", "initials": "T"}, {"family": "Borkowska", "given": "Marta", "initials": "M"}, {"family": "Povoa", "given": "Pedro", "initials": "P"}, {"family": "Iliopoulou", "given": "Katerina", "initials": "K"}, {"family": "Artigas", "given": "Antonio", "initials": "A"}, {"family": "Schaller", "given": "Stefan J", "initials": "SJ"}, {"family": "Hari", "given": "Manu Shankar", "initials": "MS"}, {"family": "Pellegrini", "given": "Mariangela", "initials": "M"}, {"family": "Darmon", "given": "Michael", "initials": "M"}, {"family": "Kesecioglu", "given": "Jozef", "initials": "J"}, {"family": "Cecconi", "given": "Maurizio", "initials": "M"}, {"family": "ESICM", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-08", "journal": {"title": "Ann Intensive Care", "issn": "2110-5820", "volume": "10", "issue": "1", "pages": "110", "issn-l": null}, "abstract": "The COVID-19 pandemic has resulted in an unprecedented healthcare crisis with a high prevalence of psychological distress in healthcare providers. We sought to document the prevalence of burnout syndrome amongst intensivists facing the COVID-19 outbreak.\n\nCross-sectional survey among intensivists part of the European Society of Intensive Care Medicine. Symptoms of severe burnout, anxiety and depression were collected. Factors independently associated with severe burnout were assessed using Cox model.\n\nResponse rate was 20% (1001 completed questionnaires were returned, 45 years [39-53], 34% women, from 85 countries, 12 regions, 50% university-affiliated hospitals). The prevalence of symptoms of anxiety and depression or severe burnout was 46.5%, 30.2%, and 51%, respectively, and varied significantly across regions. Rating of the relationship between intensivists and other ICU stakeholders differed significantly according to the presence of anxiety, depression, or burnout. Similar figures were reported for their rating of the ethical climate or the quality of the decision-making. Factors independently associated with anxiety were female gender (HR 1.85 [1.33-2.55]), working in a university-affiliated hospital (HR 0.58 [0.42-0.80]), living in a city of > 1 million inhabitants (HR 1.40 [1.01-1.94]), and clinician's rating of the ethical climate (HR 0.83 [0.77-0.90]). Independent determinants of depression included female gender (HR 1.63 [1.15-2.31]) and clinician's rating of the ethical climate (HR 0.84 [0.78-0.92]). Factors independently associated with symptoms of severe burnout included age (HR 0.98/year [0.97-0.99]) and clinician's rating of the ethical climate (HR 0.76 [0.69-0.82]).\n\nThe COVID-19 pandemic has had an overwhelming psychological impact on intensivists. Follow-up, and management are warranted to assess long-term psychological outcomes and alleviate the psychological burden of the pandemic on frontline personnel.", "doi": "10.1186/s13613-020-00722-3", "pmid": "32770449", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13613-020-00722-3"}, {"db": "pmc", "key": "PMC7414284"}], "notes": [], "created": "2020-12-07T13:34:57.801Z", "modified": "2020-12-07T13:35:52.082Z"}, {"entity": "publication", "iuid": "d45fc21e8154403c809bf4467cd00f70", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d45fc21e8154403c809bf4467cd00f70.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d45fc21e8154403c809bf4467cd00f70"}}, "title": "COVID-19-a very visible pandemic.", "authors": [{"family": "Ewing", "given": "Andrew", "initials": "A"}], "type": "letter", "published": "2020-08-08", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "396", "issue": "10248", "pages": "e18", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)31676-7", "pmid": "32771113", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31676-7"}], "notes": [], "created": "2020-12-07T13:34:10.903Z", "modified": "2020-12-07T13:34:10.913Z"}, {"entity": "publication", "iuid": "fb03bfdb9d4845aa81ab5fc091a90b93", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb03bfdb9d4845aa81ab5fc091a90b93.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb03bfdb9d4845aa81ab5fc091a90b93"}}, "title": "COVID-19-a very visible pandemic.", "authors": [{"family": "King", "given": "Carina", "initials": "C"}, {"family": "Einhorn", "given": "Lena", "initials": "L"}, {"family": "Brusselaers", "given": "Nele", "initials": "N"}, {"family": "Carlsson", "given": "Marcus", "initials": "M"}, {"family": "Einhorn", "given": "Stefan", "initials": "S"}, {"family": "Elgh", "given": "Fredrik", "initials": "F"}, {"family": "Fris\u00e9n", "given": "Jonas", "initials": "J"}, {"family": "Gustafsson", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Hanson", "given": "Stefan", "initials": "S"}, {"family": "Hanson", "given": "Claudia", "initials": "C"}, {"family": "Hedner", "given": "Thomas", "initials": "T"}, {"family": "Isaksson", "given": "Olle", "initials": "O"}, {"family": "Jansson", "given": "Anders", "initials": "A"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "L\u00f6tvall", "given": "Jan", "initials": "J"}, {"family": "Lundback", "given": "Bo", "initials": "B"}, {"family": "Olsen", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "S\u00f6derberg-Naucl\u00e9r", "given": "Cecilia", "initials": "C"}, {"family": "Wahlin", "given": "Anders", "initials": "A"}, {"family": "Steineck", "given": "Gunner", "initials": "G"}, {"family": "Vahlne", "given": "Anders", "initials": "A"}], "type": "letter", "published": "2020-08-08", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "396", "issue": "10248", "pages": "e15", "issn-l": "0140-6736"}, "abstract": "Review", "doi": "10.1016/S0140-6736(20)31672-X", "pmid": "32771110", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31672-X"}], "notes": [], "created": "2020-11-11T07:18:55.672Z", "modified": "2020-12-07T13:34:19.209Z"}, {"entity": "publication", "iuid": "046b2eb278b84654a47ee7b17c847c38", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/046b2eb278b84654a47ee7b17c847c38.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/046b2eb278b84654a47ee7b17c847c38"}}, "title": "COVID-19-a very visible pandemic.", "authors": [{"family": "Lindahl", "given": "Johanna F", "initials": "JF"}, {"family": "Olsen", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "letter", "published": "2020-08-08", "journal": {"title": "Lancet", "issn": "1474-547X", "issn-l": "0140-6736", "volume": "396", "issue": "10248", "pages": "e16"}, "abstract": null, "doi": "10.1016/S0140-6736(20)31674-3", "pmid": "32771111", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31674-3"}], "notes": [], "created": "2020-11-18T17:16:56.095Z", "modified": "2020-12-11T12:51:30.151Z"}, {"entity": "publication", "iuid": "0c0569b2f3b942bd91e0c502e055ab57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c0569b2f3b942bd91e0c502e055ab57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c0569b2f3b942bd91e0c502e055ab57"}}, "title": "COVID-19-a very visible pandemic - Author's reply.", "authors": [{"family": "Giesecke", "given": "Johan", "initials": "J"}], "type": "letter", "published": "2020-08-08", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "396", "issue": "10248", "pages": "e20", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)31677-9", "pmid": "32771115", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31677-9"}], "notes": [], "created": "2020-12-07T13:33:42.158Z", "modified": "2020-12-07T13:33:42.170Z"}, {"entity": "publication", "iuid": "608402be419043abb6ab5e52ee0617a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/608402be419043abb6ab5e52ee0617a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/608402be419043abb6ab5e52ee0617a0"}}, "title": "The formidable task of fighting COVID-19 in Sudan.", "authors": [{"family": "Elhadi", "given": "Yasir Ahmed Mohammed", "initials": "YAM"}, {"family": "Adebisi", "given": "Yusuff Adebayo", "initials": "YA"}, {"family": "Hassan", "given": "Khlood Fathi", "initials": "KF"}, {"family": "Mohammed", "given": "Salma Elmukashfi Eltaher", "initials": "SEE"}, {"family": "Lin", "given": "Xu", "initials": "X"}, {"family": "Lucero-Prisno Iii", "given": "Don Eliseo", "initials": "DE"}], "type": "journal article", "published": "2020-08-07", "journal": {"title": "Pan Afr Med J", "issn": "1937-8688", "issn-l": null, "volume": "35", "issue": "Suppl 2", "pages": "137"}, "abstract": "Commentary\r\nSudan is facing a formidable task of fighting COVID-19. The country is suddenly challenged by this health issue that will test its path towards peace, stability, and development. The fragile task of handling COVID-19 epidemic in Sudan is brought about by several factors such as the weak healthcare system and political conflicts, that have been intertwined with the recent regime. Even before the COVID-19 pandemic, there was already high unemployment, soaring inflation and lack of social protection and safety nets for its populace. The government has been trying its best to address the pandemic, however, much still needs to be done. Neglecting Sudan by the international community in terms of support towards containment of COVID-19 has grievous implications for transition out of military dictatorship and efforts to curb the pandemic globally. As no country is safe if all is not safe. It is essential that Sudan should leverage on innovations, country-compatible measures, and other tailor-made strategies for effective responses.", "doi": "10.11604/pamj.supp.2020.35.137.24984", "pmid": "33193952", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "PAMJ-35-2-137"}, {"db": "pmc", "key": "PMC7608774"}], "notes": [], "created": "2020-11-30T16:14:57.847Z", "modified": "2020-12-11T12:51:48.786Z"}, {"entity": "publication", "iuid": "7a2b0ec035284b22995f88d44590c3be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a2b0ec035284b22995f88d44590c3be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a2b0ec035284b22995f88d44590c3be"}}, "title": "Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients.", "authors": [{"family": "Stebbing", "given": "Justin", "initials": "J"}, {"family": "Krishnan", "given": "Venkatesh", "initials": "V"}, {"family": "de Bono", "given": "Stephanie", "initials": "S"}, {"family": "Ottaviani", "given": "Silvia", "initials": "S"}, {"family": "Casalini", "given": "Giacomo", "initials": "G"}, {"family": "Richardson", "given": "Peter J", "initials": "PJ"}, {"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Lauschke", "given": "Volker M", "initials": "VM"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Youhanna", "given": "Sonia", "initials": "S"}, {"family": "Tan", "given": "Yee-Joo", "initials": "YJ"}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Sarasini", "given": "Antonella", "initials": "A"}, {"family": "Terres", "given": "Jorge A Ross", "initials": "JAR"}, {"family": "Nickoloff", "given": "Brian J", "initials": "BJ"}, {"family": "Higgs", "given": "Richard E", "initials": "RE"}, {"family": "Rocha", "given": "Guilherme", "initials": "G"}, {"family": "Byers", "given": "Nicole L", "initials": "NL"}, {"family": "Schlichting", "given": "Douglas E", "initials": "DE"}, {"family": "Nirula", "given": "Ajay", "initials": "A"}, {"family": "Cardoso", "given": "Anabela", "initials": "A"}, {"family": "Corbellino", "given": "Mario", "initials": "M"}, {"family": "Sacco Baricitinib Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-07", "journal": {"title": "EMBO Mol Med", "issn": "1757-4684", "volume": "12", "issue": "8", "pages": "e12697", "issn-l": "1757-4676"}, "abstract": "Baricitinib is an oral Janus kinase (JAK)1/JAK2 inhibitor approved for the treatment of rheumatoid arthritis (RA) that was independently predicted, using artificial intelligence (AI) algorithms, to be useful for COVID-19 infection via proposed anti-cytokine effects and as an inhibitor of host cell viral propagation. We evaluated the in vitro pharmacology of baricitinib across relevant leukocyte subpopulations coupled to its in vivo pharmacokinetics and showed it inhibited signaling of cytokines implicated in COVID-19 infection. We validated the AI-predicted biochemical inhibitory effects of baricitinib on human numb-associated kinase (hNAK) members measuring nanomolar affinities for AAK1, BIKE, and GAK. Inhibition of NAKs led to reduced viral infectivity with baricitinib using human primary liver spheroids. These effects occurred at exposure levels seen clinically. In a case series of patients with bilateral COVID-19 pneumonia, baricitinib treatment was associated with clinical and radiologic recovery, a rapid decline in SARS-CoV-2 viral load, inflammatory markers, and IL-6 levels. Collectively, these data support further evaluation of the anti-cytokine and anti-viral activity of baricitinib and support its assessment in randomized trials in hospitalized COVID-19 patients.", "doi": "10.15252/emmm.202012697", "pmid": "32473600", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7300657"}], "notes": [], "created": "2020-11-25T09:23:21.591Z", "modified": "2021-02-26T08:45:03.060Z"}, {"entity": "publication", "iuid": "145941fb72144cf3ae765c4b162cb89a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/145941fb72144cf3ae765c4b162cb89a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/145941fb72144cf3ae765c4b162cb89a"}}, "title": "Genetic and Phenotypic Evidence for the Causal Relationship Between Aging and COVID-19", "authors": [{"family": "Ying", "given": "Kejun", "initials": "K"}, {"family": "Zhai", "given": "Ranran", "initials": "R"}, {"family": "Pyrkov", "given": "Timothy V", "initials": "TV"}, {"family": "Mariotti", "given": "Marco", "initials": "M"}, {"family": "Fedichev", "given": "Peter O", "initials": "PO"}, {"family": "Shen", "given": "Xia", "initials": "X"}, {"family": "Gladyshev", "given": "Vadim N", "initials": "VN"}], "type": "posted-content", "published": "2020-08-07", "journal": {"title": "", "issn": null, "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1101/2020.08.06.20169854", "pmid": null, "labels": {"Category: Genomics & transcriptomics": null, "Type: Preprint": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://www.medrxiv.org/content/10.1101/2020.08.06.20169854v2.supplementary-material", "description": "Supplementary information contains information on publicly available data sources used, instruments used, data on loci associated with risk factors, and genetic correlations between lifespan-related traits and COVID-19"}, {"db": "UK Biobank", "key": "Data used from biobank under Application Number 21988", "description": null}], "notes": [], "created": "2021-06-09T19:33:49.695Z", "modified": "2021-11-18T08:40:25.074Z"}, {"entity": "publication", "iuid": "1c5f8d11e66f46b1828d45f505b2919b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1c5f8d11e66f46b1828d45f505b2919b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1c5f8d11e66f46b1828d45f505b2919b"}}, "title": "Early Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19.", "authors": [{"family": "Alexander", "given": "Jan", "initials": "J"}, {"family": "Tinkov", "given": "Alexey", "initials": "A"}, {"family": "Strand", "given": "Tor A", "initials": "TA"}, {"family": "Alehagen", "given": "Urban", "initials": "U"}, {"family": "Skalny", "given": "Anatoly", "initials": "A"}, {"family": "Aaseth", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2020-08-07", "journal": {"title": "Nutrients", "issn": "2072-6643", "volume": "12", "issue": "8", "issn-l": null}, "abstract": "The novel coronavirus infection (COVID-19) conveys a serious threat globally to health and economy because of a lack of vaccines and specific treatments. A common factor for conditions that predispose for serious progress is a low-grade inflammation, e.g., as seen in metabolic syndrome, diabetes, and heart failure, to which micronutrient deficiencies may contribute. The aim of the present article was to explore the usefulness of early micronutrient intervention, with focus on zinc, selenium, and vitamin D, to relieve escalation of COVID-19.\n\nWe conducted an online search for articles published in the period 2010-2020 on zinc, selenium, and vitamin D, and corona and related virus infections.\n\nThere were a few studies providing direct evidence on associations between zinc, selenium, and vitamin D, and COVID-19. Adequate supply of zinc, selenium, and vitamin D is essential for resistance to other viral infections, immune function, and reduced inflammation. Hence, it is suggested that nutrition intervention securing an adequate status might protect against the novel coronavirus SARS-CoV-2 (Severe Acute Respiratory Syndrome - coronavirus-2) and mitigate the course of COVID-19.\n\nWe recommended initiation of adequate supplementation in high-risk areas and/or soon after the time of suspected infection with SARS-CoV-2. Subjects in high-risk groups should have high priority as regards this nutritive adjuvant therapy, which should be started prior to administration of specific and supportive medical measures.", "doi": "10.3390/nu12082358", "pmid": "32784601", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "nu12082358"}, {"db": "pmc", "key": "PMC7468884"}], "notes": [], "created": "2020-11-30T08:41:02.999Z", "modified": "2020-11-30T08:41:03.023Z"}, {"entity": "publication", "iuid": "c6ecdfad60ee4db38c12af7152621b7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c6ecdfad60ee4db38c12af7152621b7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c6ecdfad60ee4db38c12af7152621b7e"}}, "title": "COVID-19 salivary signature: diagnostic and research opportunities.", "authors": [{"family": "Sapkota", "given": "Dipak", "initials": "D"}, {"family": "S\u00f8land", "given": "Tine Merete", "initials": "TM"}, {"family": "Galtung", "given": "Hilde Kanli", "initials": "HK"}, {"family": "Sand", "given": "Lars Peter", "initials": "LP"}, {"family": "Giannecchini", "given": "Simone", "initials": "S"}, {"family": "To", "given": "Kelvin K W", "initials": "KKW"}, {"family": "Mendes-Correa", "given": "Maria Cassia", "initials": "MC"}, {"family": "Giglio", "given": "Daniel", "initials": "D"}, {"family": "Hass\u00e9us", "given": "Bengt", "initials": "B"}, {"family": "Braz-Silva", "given": "Paulo Henrique", "initials": "PH"}], "type": "journal article", "published": "2020-08-07", "journal": {"title": "J Clin Pathol", "issn": "1472-4146", "volume": null, "issue": null, "issn-l": null}, "abstract": "The COVID-19 (caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)) epidemic started in Wuhan (Hubei Province, China) in mid-December 2019 and quickly spread across the world as a pandemic. As a key to tracing the disease and to implement strategies aimed at breaking the chain of disease transmission, extensive testing for SARS-CoV-2 was suggested. Although nasopharyngeal/oropharyngeal swabs are the most commonly used biological samples for SARS-CoV-2 diagnosis, they have a number of limitations related to sample collection and healthcare personnel safety. In this context, saliva is emerging as a promising alternative to nasopharyngeal/oropharyngeal swabs for COVID-19 diagnosis and monitoring. Saliva collection, being a non-invasive approach with possibility for self-collection, circumvents to a great extent the limitations associated with the use of nasopharyngeal/oropharyngeal swabs. In addition, various salivary biomarkers including the salivary metabolomics offer a high promise to be useful for better understanding of COVID-19 and possibly in the identification of patients with various degrees of severity, including asymptomatic carriers. This review summarises the clinical and scientific basis for the potential use of saliva for COVID-19 diagnosis and disease monitoring. Additionally, we discuss saliva-based biomarkers and their potential clinical and research applications related to COVID-19.", "doi": "10.1136/jclinpath-2020-206834", "pmid": "32769214", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jclinpath-2020-206834"}], "notes": [], "created": "2020-11-30T08:42:54.384Z", "modified": "2020-11-30T08:42:54.407Z"}, {"entity": "publication", "iuid": "25d7fe6e2f794d6297df25b9325629dc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/25d7fe6e2f794d6297df25b9325629dc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/25d7fe6e2f794d6297df25b9325629dc"}}, "title": "COVID-19 and immunological regulations - from basic and translational aspects to clinical implications.", "authors": [{"family": "Sch\u00f6n", "given": "Michael P", "initials": "MP"}, {"family": "Berking", "given": "Carola", "initials": "C"}, {"family": "Biedermann", "given": "Tilo", "initials": "T"}, {"family": "Buhl", "given": "Timo", "initials": "T"}, {"family": "Erpenbeck", "given": "Luise", "initials": "L"}, {"family": "Eyerich", "given": "Kilian", "initials": "K"}, {"family": "Eyerich", "given": "Stefanie", "initials": "S"}, {"family": "Ghoreschi", "given": "Kamran", "initials": "K"}, {"family": "Goebeler", "given": "Matthias", "initials": "M"}, {"family": "Ludwig", "given": "Ralf J", "initials": "RJ"}, {"family": "Sch\u00e4kel", "given": "Knut", "initials": "K"}, {"family": "Schilling", "given": "Bastian", "initials": "B"}, {"family": "Schlapbach", "given": "Christoph", "initials": "C"}, {"family": "Stary", "given": "Georg", "initials": "G"}, {"family": "von Stebut", "given": "Esther", "initials": "E"}, {"family": "Steinbrink", "given": "Kerstin", "initials": "K"}], "type": "journal article", "published": "2020-08-06", "journal": {"title": "J Dtsch Dermatol Ges", "issn": "1610-0387", "volume": null, "issue": null, "issn-l": "1610-0379"}, "abstract": "The COVID-19 pandemic caused by SARS-CoV-2 has far-reaching direct and indirect medical consequences. These include both the course and treatment of diseases. It is becoming increasingly clear that infections with SARS-CoV-2 can cause considerable immunological alterations, which particularly also affect pathogenetically and/or therapeutically relevant factors. Against this background we summarize here the current state of knowledge on the interaction of SARS-CoV-2/COVID-19 with mediators of the acute phase of inflammation (TNF, IL-1, IL-6), type 1 and type 17 immune responses (IL-12, IL-23, IL-17, IL-36), type 2 immune reactions (IL-4, IL-13, IL-5, IL-31, IgE), B-cell immunity, checkpoint regulators (PD-1, PD-L1, CTLA4), and orally druggable signaling pathways (JAK, PDE4, calcineurin). In addition, we discuss in this context non-specific immune modulation by glucocorticosteroids, methotrexate, antimalarial drugs, azathioprine, dapsone, mycophenolate mofetil and fumaric acid esters, as well as neutrophil granulocyte-mediated innate immune mechanisms. From these recent findings we derive possible implications for the therapeutic modulation of said immunological mechanisms in connection with SARS-CoV-2/COVID-19. Although, of course, the greatest care should be taken with patients with immunologically mediated diseases or immunomodulating therapies, it appears that many treatments can also be carried out during the COVID-19 pandemic; some even appear to alleviate COVID-19.", "doi": "10.1111/ddg.14169", "pmid": "32761894", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7436872"}], "notes": [], "created": "2020-11-26T12:16:43.799Z", "modified": "2020-11-30T08:42:56.759Z"}, {"entity": "publication", "iuid": "36ec715ded154e0d82da66e25352c506", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/36ec715ded154e0d82da66e25352c506.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/36ec715ded154e0d82da66e25352c506"}}, "title": "International variation in the management of severe COVID-19 patients.", "authors": [{"family": "Azoulay", "given": "Elie", "initials": "E"}, {"family": "de Waele", "given": "Jan", "initials": "J"}, {"family": "Ferrer", "given": "Ricard", "initials": "R"}, {"family": "Staudinger", "given": "Thomas", "initials": "T"}, {"family": "Borkowska", "given": "Marta", "initials": "M"}, {"family": "Povoa", "given": "Pedro", "initials": "P"}, {"family": "Iliopoulou", "given": "Katerina", "initials": "K"}, {"family": "Artigas", "given": "Antonio", "initials": "A"}, {"family": "Schaller", "given": "Stefan J", "initials": "SJ"}, {"family": "Shankar-Hari", "given": "Manu", "initials": "M"}, {"family": "Pellegrini", "given": "Mariangela", "initials": "M"}, {"family": "Darmon", "given": "Michael", "initials": "M"}, {"family": "Kesecioglu", "given": "Jozef", "initials": "J"}, {"family": "Cecconi", "given": "Maurizio", "initials": "M"}], "type": "journal article", "published": "2020-08-05", "journal": {"title": "Crit Care", "issn": "1466-609X", "volume": "24", "issue": "1", "pages": "486", "issn-l": "1364-8535"}, "abstract": "There is little evidence to support the management of severe COVID-19 patients.\n\nTo document this variation in practices, we performed an online survey (April 30-May 25, 2020) on behalf of the European Society of Intensive Care Medicine (ESICM). A case vignette was sent to ESICM members. Questions investigated practices for a previously healthy 39-year-old patient presenting with severe hypoxemia from COVID-19 infection.\n\nA total of 1132 ICU specialists (response rate 20%) from 85 countries (12 regions) responded to the survey. The survey provides information on the heterogeneity in patient's management, more particularly regarding the timing of ICU admission, the first line oxygenation strategy, optimization of management, and ventilatory settings in case of refractory hypoxemia. Practices related to antibacterial, antiviral, and anti-inflammatory therapies are also investigated.\n\nThere are important practice variations in the management of severe COVID-19 patients, including differences at regional and individual levels. Large outcome studies based on multinational registries are warranted.", "doi": "10.1186/s13054-020-03194-w", "pmid": "32758266", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-020-03194-w"}, {"db": "pmc", "key": "PMC7403819"}], "notes": [], "created": "2020-12-07T15:44:14.482Z", "modified": "2021-02-26T08:45:48.038Z"}, {"entity": "publication", "iuid": "37c9a6ce93fa4bbba28a966ae11c4157", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/37c9a6ce93fa4bbba28a966ae11c4157.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/37c9a6ce93fa4bbba28a966ae11c4157"}}, "title": "High seroprevalence of SARS-CoV-2 in elderly care employees in Sweden.", "authors": [{"family": "Lindahl", "given": "Johanna F", "initials": "JF"}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Esmaeilzadeh", "given": "Mouna", "initials": "M"}, {"family": "Olsen", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Winter", "given": "Reidar", "initials": "R"}, {"family": "Amer", "given": "Stefan", "initials": "S"}, {"family": "Moln\u00e1r", "given": "Christian", "initials": "C"}, {"family": "Svalberg", "given": "Ann", "initials": "A"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "journal article", "published": "2020-08-05", "journal": {"title": "Infect Ecol Epidemiol", "issn": "2000-8686", "issn-l": "2000-8686", "volume": "10", "issue": "1", "pages": "1789036"}, "abstract": "The COVID-19 pandemic is growing and spread in the Swedish elderly care system during April 2020. The increasing number of employees on sick-leave due to COVID-19 created severe logistic problems. Some elderly care homes therefore started to screen their personnel to secure the safety of the elderly and to avoid unnecessary quarantine of potentially immune employees. Secondary data from a screening with a COVID-19 rapid test for detection of SARS-CoV-2-specific IgM and IgG of 1,005 employees in 22 elderly care homes in Stockholm, Sweden, were analyzed. Seropositive employees were found in 21 out of the 22 care homes. In total, 23% (231/1,005) of the employees tested positive for antibodies against SARS-CoV-2, and 14.3% (144/1,005) were found positive for IgM (either alone or combined with IgG), indicating recent or present infection. Of those that tested seropositive, 46.5% did not report any clinical symptoms, indicating pre- or asymptomatic infections. Reported symptoms with the highest correlation with seropositivity were fever and loss of smell and taste. These results suggest that antibody testing of employees in elderly care homes is valuable for surveillance of disease development and a crucial screening tool in the effort to decrease the death toll in this pandemic.", "doi": "10.1080/20008686.2020.1789036", "pmid": "32939231", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Serology": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.1080/20008686.2020.1789036", "description": "Serological responses of 1,005 employees to SARS-CoV-2 at 22 different elderly care homes in Stockholm"}], "notes": [], "created": "2020-10-30T11:59:27.014Z", "modified": "2021-02-26T08:46:49.351Z"}, {"entity": "publication", "iuid": "e0b776a8100d4f16ba4500c1a3f97b17", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e0b776a8100d4f16ba4500c1a3f97b17.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e0b776a8100d4f16ba4500c1a3f97b17"}}, "title": "Does COVID-19 teach us anything for our future?", "authors": [{"family": "Ralph Edwards", "given": "Ivor", "initials": "I"}, {"family": "Lindquist", "given": "Marie", "initials": "M"}], "type": "editorial", "published": "2020-08-04", "journal": {"title": "Int J Risk Saf Med", "issn": "1878-6847", "volume": "31", "issue": "3", "pages": "107-109", "issn-l": null}, "abstract": null, "doi": "10.3233/JRS-201006", "pmid": "32741780", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "JRS201006"}], "notes": [], "created": "2020-12-07T16:04:51.880Z", "modified": "2020-12-07T16:04:51.890Z"}, {"entity": "publication", "iuid": "53523ecc594e44228bfa5d7a00454b93", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53523ecc594e44228bfa5d7a00454b93.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53523ecc594e44228bfa5d7a00454b93"}}, "title": "Charting a \"Green Path\" for Recovery from COVID-19.", "authors": [{"family": "Mukanjari", "given": "Samson", "initials": "S"}, {"family": "Sterner", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2020-08-04", "journal": {"title": "Environ Resour Econ (Dordr)", "issn": "0924-6460", "volume": null, "issue": null, "pages": "1-29", "issn-l": null}, "abstract": "Should the economic recovery from the 2019 novel coronavirus disease (COVID-19) be green? The current crisis is so severe that we should not take the answer for granted. It requires serious thought and we start by reviewing some arguments for and against a green approach. A crucial element is of course to see how different industries fare in the current crisis. Our empirical contribution is to examine daily stock returns for firms from the STOXX Europe 600 index. We find that firms with higher carbon intensities experienced significantly large decreases in stock values particularly those within the crude petroleum extraction, air transport and coke and refined petroleum industries. Our tentative conclusion is that efforts to revitalize the economy should avoid subsidizing stranded assets and instead target the industries of the future. However, identifying these will not necessarily be easy. We find, for example, that having an official ESG \"climate change policy\" has no effect on firm performance during the pandemic. We suggest possible ways of designing a new form of more informative index.", "doi": "10.1007/s10640-020-00479-0", "pmid": "32836858", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "479"}, {"db": "pmc", "key": "PMC7399619"}], "notes": [], "created": "2020-12-07T10:38:46.542Z", "modified": "2020-12-07T10:38:46.565Z"}, {"entity": "publication", "iuid": "a218165be69a45edb93660bd7b6cfe16", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a218165be69a45edb93660bd7b6cfe16.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a218165be69a45edb93660bd7b6cfe16"}}, "title": "Autoimmune Encephalitis Presenting with Acute Excited Catatonia in a 40-Year-Old Male Patient with Covid-19", "authors": [{"family": "Mulder", "given": "Jan", "initials": "J"}, {"family": "Feresiadou", "given": "Amalia", "initials": "A"}, {"family": "Fallmar", "given": "David", "initials": "D"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "Rasmusson", "given": "Annica", "initials": "A"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Cunningham", "given": "Janet Lynn", "initials": "JL"}], "type": "posted-content", "published": "2020-08-04", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.07.23.20160770", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-08T07:05:15.963Z", "modified": "2021-02-26T08:45:48.537Z"}, {"entity": "publication", "iuid": "fb5f4bebc9124a8794bd30fa72135cff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb5f4bebc9124a8794bd30fa72135cff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb5f4bebc9124a8794bd30fa72135cff"}}, "title": "Tocilizumab shortens time on mechanical ventilation and length of hospital stay in patients with severe COVID-19: a retrospective cohort study.", "authors": [{"family": "Eimer", "given": "J", "initials": "J"}, {"family": "Vesterbacka", "given": "J", "initials": "J"}, {"family": "Svensson", "given": "A-K", "initials": "A"}, {"family": "Stojanovic", "given": "B", "initials": "B"}, {"family": "Wagrell", "given": "C", "initials": "C"}, {"family": "S\u00f6nnerborg", "given": "A", "initials": "A"}, {"family": "Nowak", "given": "P", "initials": "P"}], "type": "letter", "published": "2020-08-03", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1111/joim.13162", "pmid": "32744399", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7436415"}], "notes": [], "created": "2020-12-04T08:37:40.803Z", "modified": "2021-02-26T08:45:03.368Z"}, {"entity": "publication", "iuid": "bc6e19c1df8142dfaa90075bd10b585e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bc6e19c1df8142dfaa90075bd10b585e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bc6e19c1df8142dfaa90075bd10b585e"}}, "title": "Misleading media coverage of Sweden's response to covid-19.", "authors": [{"family": "Irwin", "given": "Rachel E", "initials": "RE"}], "type": "letter", "published": "2020-08-03", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "370", "issue": null, "pages": "m3031", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m3031", "pmid": "32747388", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-07T16:00:57.583Z", "modified": "2023-01-13T13:50:00.714Z"}, {"entity": "publication", "iuid": "62f5193eb1274e2598aa5bb32f854c43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/62f5193eb1274e2598aa5bb32f854c43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/62f5193eb1274e2598aa5bb32f854c43"}}, "title": "Social determinants of health and inequalities in COVID-19.", "authors": [{"family": "Burstr\u00f6m", "given": "Bo", "initials": "B"}, {"family": "Tao", "given": "Wenjing", "initials": "W"}], "type": "journal article", "published": "2020-08-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": "30", "issue": "4", "pages": "617-618"}, "abstract": null, "doi": "10.1093/eurpub/ckaa095", "pmid": "32638998", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5868718"}, {"db": "pmc", "key": "PMC7454505"}], "notes": [], "created": "2020-12-04T08:34:26.857Z", "modified": "2021-01-25T10:28:30.704Z"}, {"entity": "publication", "iuid": "cc1abb039bfa44da943ee142c71545d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc1abb039bfa44da943ee142c71545d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc1abb039bfa44da943ee142c71545d0"}}, "title": "\ufeffEASAPS/ESPRAS Considerations in getting back to work in Plastic Surgery with the COVID-19 Pandemic - A European point of view.", "authors": [{"family": "van Heijningen", "given": "Ivar", "initials": "I"}, {"family": "Frank", "given": "Konstantin", "initials": "K"}, {"family": "Almeida", "given": "Francisco", "initials": "F"}, {"family": "B\u00f6sch", "given": "Urs", "initials": "U"}, {"family": "Bradic", "given": "Nicola", "initials": "N"}, {"family": "Costa", "given": "Horacio", "initials": "H"}, {"family": "Demirdover", "given": "Cenk", "initials": "C"}, {"family": "Henley", "given": "Mark", "initials": "M"}, {"family": "Kamolz", "given": "Lars Peter", "initials": "LP"}, {"family": "Rouif", "given": "Michel", "initials": "M"}, {"family": "Spendel", "given": "Stephan", "initials": "S"}, {"family": "Russe-Wilflingseder", "given": "Katharina", "initials": "K"}, {"family": "Stark", "given": "Birgit", "initials": "B"}, {"family": "Giunta", "given": "Riccardo E", "initials": "RE"}, {"family": "Parreira", "given": "Jose Carlos", "initials": "JC"}, {"family": "Zic", "given": "Rado", "initials": "R"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Handchir Mikrochir Plast Chir", "issn": "1439-3980", "volume": "52", "issue": "4", "pages": "257-264", "issn-l": "0722-1819"}, "abstract": "The aim of this paper is to summarize the results of a consensus process and a European webinar of the two societies, European Association of Societies of Aesthetic Surgery (EASAPS) and the European Society of Plastic, Reconstructive and Aesthetic Societies (ESPRAS) on what is considered safe practice based on the scientific knowledge we have today. This review of the current situations gives considerations which have to be taken into account when getting back to work in plastic surgery with COVID-19 in Europe. At all times, one should be familiar the local and regional infection rates in the community, with particular emphasis on the emergence of second and third waves of the pandemic. Due to the fast-evolving nature of the COVID-19 pandemic the recommendations aim to be rather considerations than fixed guidelines and might need to be revised in near future.", "doi": "10.1055/a-1175-4169", "pmid": "32422664", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-25T08:30:59.859Z", "modified": "2020-11-30T09:07:53.328Z"}, {"entity": "publication", "iuid": "0d301750f52348f487fee1959c1b870b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d301750f52348f487fee1959c1b870b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d301750f52348f487fee1959c1b870b"}}, "title": "Vascular Surgery in Unreal Times.", "authors": [{"family": "Eilenberg", "given": "Wolf", "initials": "W"}, {"family": "Busch", "given": "Albert", "initials": "A"}, {"family": "Wagenh\u00e4user", "given": "Markus", "initials": "M"}, {"family": "Giannoukas", "given": "Athanasios", "initials": "A"}, {"family": "Wanhainen", "given": "Anders", "initials": "A"}, {"family": "Neumayer", "given": "Christoph", "initials": "C"}, {"family": "Haulon", "given": "Stephan", "initials": "S"}], "type": "editorial", "published": "2020-08-00", "journal": {"title": "Eur J Vasc Endovasc Surg", "issn": "1532-2165", "volume": "60", "issue": "2", "pages": "167-168", "issn-l": "1078-5884"}, "abstract": "Editorial", "doi": "10.1016/j.ejvs.2020.05.031", "pmid": "32605851", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1078-5884(20)30453-6"}, {"db": "pmc", "key": "PMC7320915"}], "notes": [], "created": "2020-11-22T09:36:23.824Z", "modified": "2020-12-08T15:23:07.202Z"}, {"entity": "publication", "iuid": "6ac885a2ae224f9b8751ef2a27f87f3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ac885a2ae224f9b8751ef2a27f87f3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ac885a2ae224f9b8751ef2a27f87f3d"}}, "title": "Using the prone position could help to combat the development of fast hypoxia in some patients with COVID-19.", "authors": [{"family": "Lindahl", "given": "Sten G E", "initials": "SGE"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "volume": "109", "issue": "8", "pages": "1539-1544", "issn-l": null}, "abstract": "The world is facing an explosive COVID-19 pandemic. Some cases rapidly develop deteriorating lung function, which causes deep hypoxaemia and requires urgent treatment. Many centres have started treating patients in the prone position, and oxygenation has improved considerably in some cases. Questions have been raised regarding the mechanisms behind this. The mini review provides some insights into the role of supine and prone body positions and summarises the latest understanding of the responsible mechanisms. The scope for discussion is outside the neonatal period and entirely based on experimental and clinical experiences related to adults. The human respiratory system is a complex interplay of many different variables. Therefore, this mini review has prioritised previous and ongoing research to find explanations based on three scientific areas: gravity, lung structure and fractal geometry and vascular regulation. It concludes that gravity is one of the variables responsible for ventilation/perfusion matching but in concert with lung structure and fractal geometry, ventilation and regulation of lung vascular tone. Since ventilation distribution does not change between supine and prone positions, the higher expression of nitric oxide in dorsal lung vessels than in ventral vessels is likely to be the most important mechanism behind enhanced oxygenation in the prone position.", "doi": "10.1111/apa.15382", "pmid": "32484966", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7301016"}], "notes": [], "created": "2020-11-25T08:08:41.192Z", "modified": "2020-11-30T09:02:31.821Z"}, {"entity": "publication", "iuid": "27bae21f98f64e098fe22a4be2b9d608", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27bae21f98f64e098fe22a4be2b9d608.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27bae21f98f64e098fe22a4be2b9d608"}}, "title": "Updated rapid risk assessment from ECDC on coronavirus disease (COVID-19) pandemic in the EU/EEA and the UK: resurgence of cases.", "authors": [{"family": "Eurosurveillance editorial team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "32", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.32.2008131", "pmid": "32794445", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7427298"}], "notes": [], "created": "2020-12-07T13:22:35.411Z", "modified": "2020-12-07T13:22:35.421Z"}, {"entity": "publication", "iuid": "b9c70b65997f4554a82535ca0072b2b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9c70b65997f4554a82535ca0072b2b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9c70b65997f4554a82535ca0072b2b9"}}, "title": "The COVID-19 pandemic and the Swedish strategy: Epidemiology and postmodernism.", "authors": [{"family": "Lindstr\u00f6m", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "SSM Popul Health", "issn": "2352-8273", "volume": "11", "issue": null, "pages": "100643", "issn-l": null}, "abstract": "The aim is to outline the underlying epidemiological thinking and mentality in post-materialist and postmodern Sweden behind the Swedish strategy. The aim is not to investigate the handling of the pandemic in Sweden in the long-run. Overconfidence in herd immunity, overconfidence in individual responsibility in a pandemic needing community-centered approaches, overconfidence in evidence-based medicine and neglect to coordinate with the WHO and other countries may be associated with post-materialist values and postmodernism including opposition against modern authority, rationality and science, and also an anti-traditionalist stance towards older generations. COVID-19 epidemiology and postmodernism may be a dangerous combination.", "doi": "10.1016/j.ssmph.2020.100643", "pmid": "32885019", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2352-8273(20)30280-9"}, {"db": "pii", "key": "100643"}, {"db": "pmc", "key": "PMC7453138"}], "notes": [], "created": "2020-12-06T07:29:56.517Z", "modified": "2020-12-06T07:29:56.540Z"}, {"entity": "publication", "iuid": "77dbed03c6fc462eb917dc197ce883ea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/77dbed03c6fc462eb917dc197ce883ea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/77dbed03c6fc462eb917dc197ce883ea"}}, "title": "Steroid-Responsive Encephalitis in Coronavirus Disease 2019.", "authors": [{"family": "Pilotto", "given": "Andrea", "initials": "A"}, {"family": "Odolini", "given": "Silvia", "initials": "S"}, {"family": "Masciocchi", "given": "Stefano", "initials": "S"}, {"family": "Comelli", "given": "Agnese", "initials": "A"}, {"family": "Volonghi", "given": "Irene", "initials": "I"}, {"family": "Gazzina", "given": "Stefano", "initials": "S"}, {"family": "Nocivelli", "given": "Sara", "initials": "S"}, {"family": "Pezzini", "given": "Alessandro", "initials": "A"}, {"family": "Foc\u00e0", "given": "Emanuele", "initials": "E"}, {"family": "Caruso", "given": "Arnaldo", "initials": "A"}, {"family": "Leonardi", "given": "Matilde", "initials": "M"}, {"family": "Pasolini", "given": "Maria P", "initials": "MP"}, {"family": "Gasparotti", "given": "Roberto", "initials": "R"}, {"family": "Castelli", "given": "Francesco", "initials": "F"}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Padovani", "given": "Alessandro", "initials": "A"}], "type": "case reports", "published": "2020-08-00", "journal": {"title": "Ann Neurol", "issn": "1531-8249", "volume": "88", "issue": "2", "pages": "423-427", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) infection has the potential for targeting the central nervous system, and several neurological symptoms have been described in patients with severe respiratory distress. Here, we described the case of a 60-year-old patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection but only mild respiratory abnormalities who developed an akinetic mutism attributable to encephalitis. Magnetic resonance imaging was negative, whereas electroencephalography showed generalized theta slowing. Cerebrospinal fluid analyses during the acute stage were negative for SARS-CoV-2, positive for pleocytosis and hyperproteinorrachia, and showed increased interleukin-8 and tumor necrosis factor-\u03b1 concentrations. Other infectious or autoimmune disorders were excluded. A progressive clinical improvement along with a reduction of cerebrospinal fluid parameters was observed after high-dose steroid treatment, thus arguing for an inflammatory-mediated brain involvement related to COVID-19. ANN NEUROL 2020;88:423-427.", "doi": "10.1002/ana.25783", "pmid": "32418288", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7276848"}], "notes": [], "created": "2020-12-10T08:55:43.469Z", "modified": "2021-02-26T08:45:48.330Z"}, {"entity": "publication", "iuid": "2dec25cb865b4377aafe550af4a49d56", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2dec25cb865b4377aafe550af4a49d56.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2dec25cb865b4377aafe550af4a49d56"}}, "title": "Sports Health During the SARS-Cov-2 Pandemic.", "authors": [{"family": "Timpka", "given": "Toomas", "initials": "T"}], "type": "letter", "published": "2020-08-00", "journal": {"title": "Sports Med", "issn": "1179-2035", "volume": "50", "issue": "8", "pages": "1413-1416", "issn-l": null}, "abstract": null, "doi": "10.1007/s40279-020-01288-7", "pmid": "32361898", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40279-020-01288-7"}, {"db": "pmc", "key": "PMC7195617"}], "notes": [], "created": "2020-12-10T07:24:46.451Z", "modified": "2020-12-10T07:24:46.473Z"}, {"entity": "publication", "iuid": "e2b2172a254943d9818aa55345a77951", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2b2172a254943d9818aa55345a77951.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2b2172a254943d9818aa55345a77951"}}, "title": "Society of Robotic Surgery review: recommendations regarding the risk of COVID-19 transmission during minimally invasive surgery.", "authors": [{"family": "Porter", "given": "James", "initials": "J"}, {"family": "Blau", "given": "Elliot", "initials": "E"}, {"family": "Gharagozloo", "given": "Farid", "initials": "F"}, {"family": "Martino", "given": "Martin", "initials": "M"}, {"family": "Cerfolio", "given": "Robert", "initials": "R"}, {"family": "Duvvuri", "given": "Umamaheswar", "initials": "U"}, {"family": "Caceres", "given": "Aileen", "initials": "A"}, {"family": "Badani", "given": "Ketan", "initials": "K"}, {"family": "Bhayani", "given": "Sam", "initials": "S"}, {"family": "Collins", "given": "Justin", "initials": "J"}, {"family": "Coelho", "given": "Rafael", "initials": "R"}, {"family": "Rocco", "given": "Bernard", "initials": "B"}, {"family": "Wiklund", "given": "Peter", "initials": "P"}, {"family": "Nathan", "given": "Senthil", "initials": "S"}, {"family": "Parra-Davila", "given": "Eduardo", "initials": "E"}, {"family": "Ortiz-Ortiz", "given": "Carlos", "initials": "C"}, {"family": "Maes", "given": "Kris", "initials": "K"}, {"family": "Dasgupta", "given": "Prokar", "initials": "P"}, {"family": "Patel", "given": "Vipul", "initials": "V"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "BJU Int", "issn": "1464-410X", "volume": "126", "issue": "2", "pages": "225-234", "issn-l": "1464-4096"}, "abstract": "To determine the risk of COVID-19 transmission during minimally invasive surgical (MIS) procedures METHODS: Surgical society statements regarding the risk of COVID transmission during MIS procedures were reviewed. In addition, the available literature on COVID-19 and other viral transmission in CO2 pneumoperitoneum, as well as the presence of virus in the plume created by electrocautery during MIS was reviewed. The society recommendations were compared to the available literature on the topic to create our review and recommendations to mitigate COVID-19 transmission.\n\nThe recommendations promulgated by various surgical societies evolved over time as more information became available on COVID-19 transmission. Review of the available literature on the presence of COVID-19 in CO2 pneumoperitoneum was inconclusive. There is no clear evidence of the presence of COVID-19 in plume created by electrocautery. Technologies to reduce CO2 pneumoperitoneum release into the operating room as well as filter viral particles are available and should reduce the exposure risk to operating room personnel.\n\nThere is no clear evidence of COVID-19 virus in the CO2 used during MIS procedures or in the plume created by electrocautery. Until the presence or absence of COVID-19 viral particles has been clearly established, measures to mitigate CO2 and surgical cautery plume release into the operating room should be performed. Further study on the presence of COVID-19 in MIS pneumoperitoneum and cautery plume is needed.", "doi": "10.1111/bju.15105", "pmid": "32383520", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7267386"}], "notes": [], "created": "2020-11-25T07:32:27.293Z", "modified": "2020-12-10T07:40:38.266Z"}, {"entity": "publication", "iuid": "805eae795adb4cc5a630baf15dde1a2e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/805eae795adb4cc5a630baf15dde1a2e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/805eae795adb4cc5a630baf15dde1a2e"}}, "title": "Smell and taste alterations in COVID-19: a cross-sectional analysis of different cohorts.", "authors": [{"family": "Paderno", "given": "Alberto", "initials": "A"}, {"family": "Schreiber", "given": "Alberto", "initials": "A"}, {"family": "Grammatica", "given": "Alberto", "initials": "A"}, {"family": "Raffetti", "given": "Elena", "initials": "E"}, {"family": "Tomasoni", "given": "Michele", "initials": "M"}, {"family": "Gualtieri", "given": "Tommaso", "initials": "T"}, {"family": "Taboni", "given": "Stefano", "initials": "S"}, {"family": "Zorzi", "given": "Silvia", "initials": "S"}, {"family": "Lombardi", "given": "Davide", "initials": "D"}, {"family": "Deganello", "given": "Alberto", "initials": "A"}, {"family": "Redaelli De Zinis", "given": "Luca Oscar", "initials": "LO"}, {"family": "Maroldi", "given": "Roberto", "initials": "R"}, {"family": "Mattavelli", "given": "Davide", "initials": "D"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Int Forum Allergy Rhinol", "issn": "2042-6984", "volume": "10", "issue": "8", "pages": "955-962", "issn-l": "2042-6976"}, "abstract": "Olfactory (OD) and gustatory (GD) dysfunction have been proven to be a typical symptom of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. However, their prevalence in different patient populations still needs to be clarified.\n\nA cross-sectional study was performed from March 27 to April 1, 2020, in Northern Italy. Physicians administered a survey-based questionnaire to SARS-CoV-2-positive patients with the aim of assessing symptoms, focusing on OD and GD. Two groups were studied: group A, patients hospitalized at Azianda Socio Sanitaria Territoriale (ASST) Spedali Civili University Hospital of Brescia; and group B, home-quarantined subjects.\n\nA total of 508 patients were enrolled: 295 in group A and 213 in group B. Mean age \u00b1 standard deviation (SD) was 55 \u00b1 15 years; 56% were men. Overall, OD and GD were present in 56% (95% confidence interval [CI], 51% to 60%) and 63% (95% CI, 59% to 67%) of cases, respectively. In group A, the prevalence of OD and GD was 44% (95% CI, 38% to 50%) and 52% (95% CI, 46% to 58%), respectively. In group B, the prevalence of OD and GD was 72% (95% CI, 65% to 79%) and 79% (95% CI, 73% to 84%), respectively. In the entire cohort, total loss of olfaction and taste was reported in 64% and 60% of cases, respectively. OD and GD occurred as the first symptom in 10% and 11% of cases, respectively; in the remaining cases, they occurred after a mean of 4 \u00b1 3 days following the first symptom. At the time of the questionnaire, complete resolution of OD and GD was reported in 52% and 55% of cases, respectively (mean duration, 9 \u00b1 5 days in both).\n\nOD and GD are more prevalent in home-quarantined subjects, and they are independently associated with younger age and female gender.", "doi": "10.1002/alr.22610", "pmid": "32410386", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7272886"}], "notes": [], "created": "2020-11-25T08:09:58.321Z", "modified": "2021-02-26T08:45:48.417Z"}, {"entity": "publication", "iuid": "e58494e9496644f8818bce57e34e8fc9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e58494e9496644f8818bce57e34e8fc9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e58494e9496644f8818bce57e34e8fc9"}}, "title": "School and pre-school children with type 1 diabetes during Covid-19 quarantine: The synergic effect of parental care and technology.", "authors": [{"family": "Schiaffini", "given": "Riccardo", "initials": "R"}, {"family": "Barbetti", "given": "Fabrizio", "initials": "F"}, {"family": "Rapini", "given": "Novella", "initials": "N"}, {"family": "Inzaghi", "given": "Elena", "initials": "E"}, {"family": "Deodati", "given": "Annalisa", "initials": "A"}, {"family": "Patera", "given": "Ippolita P", "initials": "IP"}, {"family": "Matteoli", "given": "Maria C", "initials": "MC"}, {"family": "Ciampalini", "given": "Paolo", "initials": "P"}, {"family": "Carducci", "given": "Chiara", "initials": "C"}, {"family": "Lorubbio", "given": "Antonella", "initials": "A"}, {"family": "Schiaffini", "given": "Gabriele", "initials": "G"}, {"family": "Cianfarani", "given": "Stefano", "initials": "S"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Diabetes Res Clin Pract", "issn": "1872-8227", "issn-l": null, "volume": "166", "issue": null, "pages": "108302"}, "abstract": "Management of Type 1 Diabetes (T1D) poses numerous challenges, especially for young children and their families. Parental care positively influencesthe outcomesofchildren with T1D, while there are often criticisms in school environment. The COVID-19 pandemic has forced children and parents to spend many hours at home and diabetes care has returned mainly in the hands of parents.\r\n\r\nTo evaluate the effectiveness of exclusive return to parental care in pre-school and school children with T1D treated with Tandem Basal IQ system during the COVID-19 pandemic.\r\n\r\n22 children (M:F = 14:8) with T1D have been evaluated. We compared insulin and CGM data (TIR, TBR and TAR) of two periods: PRE-COV and IN-COV, in which children have transitioned from normal school attendance to the exclusive care of their parents.\r\n\r\nDuring the IN-COV period a significantly (p < 0.001) higher median value of TIR (66,41%) was observed as compared to PRE-COV period (61,45%). Patients also showed a statistically significant difference (p < 0.002) between the IN-COV period and the PRE-COV period as concerning the TAR metric: respectively 29,86 \u00b1 10,6% vs 34,73 \u00b1 12,8%. The difference between the bolus insulin doses was statistically significant (PRE-COV 5,3 IU/day, IN-COV 7,9 IU/day - p < 0.05).\r\n\r\nOur observational real-life study confirms the positive effect of parental care in T1D very young children and demonstrates that during the COVID-19 pandemic it was possible to obtain a good glycometabolic compensation despite the significant change in lifestyle.", "doi": "10.1016/j.diabres.2020.108302", "pmid": "32623034", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0168-8227(20)30554-4"}, {"db": "pmc", "key": "PMC7332425"}], "notes": [], "created": "2020-12-08T15:04:58.822Z", "modified": "2022-11-10T07:12:20.042Z"}, {"entity": "publication", "iuid": "dafcf340284d46f384c44facaf351f9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dafcf340284d46f384c44facaf351f9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dafcf340284d46f384c44facaf351f9c"}}, "title": "Perceived Worsening of Tics in Adult Patients with Tourette Syndrome after the COVID-19 Outbreak.", "authors": [{"family": "Mataix-Cols", "given": "David", "initials": "D"}, {"family": "Ringberg", "given": "Helene", "initials": "H"}, {"family": "Fern\u00e1ndez de la Cruz", "given": "Lorena", "initials": "L"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Mov Disord Clin Pract", "issn": "2330-1619", "volume": "7", "issue": "6", "pages": "725-726", "issn-l": null}, "abstract": null, "doi": "10.1002/mdc3.13004", "pmid": "32775530", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "MDC313004"}, {"db": "pmc", "key": "PMC7323109"}], "notes": [], "created": "2020-12-07T13:33:12.659Z", "modified": "2021-02-26T08:45:48.786Z"}, {"entity": "publication", "iuid": "42aaa70ea4114cfc9360097b297d92df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/42aaa70ea4114cfc9360097b297d92df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/42aaa70ea4114cfc9360097b297d92df"}}, "title": "Palliative care: Essential support for patients with heart failure in the COVID-19 pandemic.", "authors": [{"family": "Hill", "given": "Loreena", "initials": "L"}, {"family": "Beattie", "given": "James M", "initials": "JM"}, {"family": "Geller", "given": "Tal Prager", "initials": "TP"}, {"family": "Baruah", "given": "Resham", "initials": "R"}, {"family": "Boyne", "given": "Josiane", "initials": "J"}, {"family": "Stolfo", "given": "Giuseppe Di", "initials": "GD"}, {"family": "Jaarsma", "given": "Tiny", "initials": "T"}], "type": "editorial", "published": "2020-08-00", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "volume": "19", "issue": "6", "pages": "469-472", "issn-l": null}, "abstract": null, "doi": "10.1177/1474515120932814", "pmid": "32515212", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-09T10:31:28.295Z", "modified": "2020-12-09T10:31:28.305Z"}, {"entity": "publication", "iuid": "7011be2092af4e399c629f8276b9f270", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7011be2092af4e399c629f8276b9f270.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7011be2092af4e399c629f8276b9f270"}}, "title": "Optimizing safety surveillance for COVID-19 vaccines.", "authors": [{"family": "Chandler", "given": "Rebecca E", "initials": "RE"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Nat Rev Immunol", "issn": "1474-1741", "volume": "20", "issue": "8", "pages": "451-452", "issn-l": "1474-1733"}, "abstract": null, "doi": "10.1038/s41577-020-0372-8", "pmid": "32555401", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41577-020-0372-8"}, {"db": "pmc", "key": "PMC7298922"}], "notes": [], "created": "2020-11-22T08:40:40.615Z", "modified": "2020-11-30T08:59:20.299Z"}, {"entity": "publication", "iuid": "d5444d00b5ee4c079ee7c5d8184eb62c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5444d00b5ee4c079ee7c5d8184eb62c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5444d00b5ee4c079ee7c5d8184eb62c"}}, "title": "On the interactions of the receptor-binding domain of SARS-CoV-1 and SARS-CoV-2 spike proteins with monoclonal antibodies and the receptor ACE2.", "authors": [{"family": "Corr\u00eaa Giron", "given": "Carolina", "initials": "C"}, {"family": "Laaksonen", "given": "Aatto", "initials": "A"}, {"family": "Barroso da Silva", "given": "Fernando L", "initials": "FL"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Virus Res", "issn": "1872-7492", "volume": "285", "issue": null, "pages": "198021", "issn-l": null}, "abstract": "A new betacoronavirus named SARS-CoV-2 has emerged as a new threat to global health and economy. A promising target for both diagnosis and therapeutics treatments of the new disease named COVID-19 is the coronavirus (CoV) spike (S) glycoprotein. By constant-pH Monte Carlo simulations and the PROCEEDpKa method, we have mapped the electrostatic epitopes for four monoclonal antibodies and the angiotensin-converting enzyme 2 (ACE2) on both SARS-CoV-1 and the new SARS-CoV-2 S receptor binding domain (RBD) proteins. We also calculated free energy of interactions and shown that the S RBD proteins from both SARS viruses binds to ACE2 with similar affinities. However, the affinity between the S RBD protein from the new SARS-CoV-2 and ACE2 is higher than for any studied antibody previously found complexed with SARS-CoV-1. Based on physical chemical analysis and free energies estimates, we can shed some light on the involved molecular recognition processes, their clinical aspects, the implications for drug developments, and suggest structural modifications on the CR3022 antibody that would improve its binding affinities for SARS-CoV-2 and contribute to address the ongoing international health crisis.", "doi": "10.1016/j.virusres.2020.198021", "pmid": "32416259", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Proteins": null}, "xrefs": [{"db": "pii", "key": "S0168-1702(20)30352-X"}, {"db": "pmc", "key": "PMC7228703"}], "notes": [], "created": "2020-12-10T08:53:57.256Z", "modified": "2021-02-26T08:47:18.863Z"}, {"entity": "publication", "iuid": "465be802f0f04f968d6d9ab340e63bb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/465be802f0f04f968d6d9ab340e63bb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/465be802f0f04f968d6d9ab340e63bb1"}}, "title": "Management strategies for children with COVID-19: ESPR practical recommendations.", "authors": [{"family": "Raissaki", "given": "Maria", "initials": "M"}, {"family": "Shelmerdine", "given": "Susan C", "initials": "SC"}, {"family": "Damasio", "given": "Maria Beatrice", "initials": "MB"}, {"family": "Toso", "given": "Seema", "initials": "S"}, {"family": "Kvist", "given": "Ola", "initials": "O"}, {"family": "Lovrenski", "given": "Jovan", "initials": "J"}, {"family": "Hirsch", "given": "Franz Wolfgang", "initials": "FW"}, {"family": "G\u00f6rkem", "given": "S\u00fcreyya Burcu", "initials": "SB"}, {"family": "Paterson", "given": "Anne", "initials": "A"}, {"family": "Arthurs", "given": "Owen J", "initials": "OJ"}, {"family": "Rossi", "given": "Andrea", "initials": "A"}, {"family": "van Schuppen", "given": "Joost", "initials": "J"}, {"family": "Petit", "given": "Philippe", "initials": "P"}, {"family": "Argyropoulou", "given": "Maria I", "initials": "MI"}, {"family": "Offiah", "given": "Amaka C", "initials": "AC"}, {"family": "Rosendahl", "given": "Karen", "initials": "K"}, {"family": "Caro-Dom\u00ednguez", "given": "Pablo", "initials": "P"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Pediatr Radiol", "issn": "1432-1998", "issn-l": null, "volume": "50", "issue": "9", "pages": "1313-1323"}, "abstract": "During the outbreak of the COVID-19 pandemic, guidelines have been issued by international, national and local authorities to address management and the need for preparedness. Children with COVID-19 differ from adults in that they are less often and less severely affected. Additional precautions required in the management of children address their increased radiosensitivity, need for accompanying carers, and methods for dealing with children in a mixed adult-paediatric institution. In this guidance document, our aim is to define a pragmatic strategy for imaging children with an emphasis on proven or suspected COVID-19 cases. Children suspected of COVID-19 should not be imaged routinely. Imaging should be performed only when expected to alter patient management, depending on symptoms, preexisting conditions and clinical evolution. In order to prevent disease transmission, it is important to manage the inpatient caseload effectively by triaging children and carers outside the hospital, re-scheduling nonurgent elective procedures and managing symptomatic children and carers as COVID-19 positive until proven otherwise. Within the imaging department one should consider conducting portable examinations with COVID-19 machines or arranging dedicated COVID-19 paediatric imaging sessions and performing routine nasopharyngeal swab testing before imaging under general anaesthesia. Finally, regular personal hygiene, appropriate usage of personal protective equipment, awareness of which procedures are considered aerosol generating and information on how to best disinfect imaging machinery after examinations should be highlighted to all staff members.", "doi": "10.1007/s00247-020-04749-3", "pmid": "32621013", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00247-020-04749-3"}, {"db": "pmc", "key": "PMC7332738"}], "notes": [], "created": "2020-12-08T15:05:31.524Z", "modified": "2020-12-11T12:52:07.380Z"}, {"entity": "publication", "iuid": "d6a624fb7c074de78500a3eff2f91098", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d6a624fb7c074de78500a3eff2f91098.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d6a624fb7c074de78500a3eff2f91098"}}, "title": "Lockdown timing and efficacy in controlling COVID-19 using mobile phone tracking.", "authors": [{"family": "Vinceti", "given": "Marco", "initials": "M"}, {"family": "Filippini", "given": "Tommaso", "initials": "T"}, {"family": "Rothman", "given": "Kenneth J", "initials": "KJ"}, {"family": "Ferrari", "given": "Fabrizio", "initials": "F"}, {"family": "Goffi", "given": "Alessia", "initials": "A"}, {"family": "Maffeis", "given": "Giuseppe", "initials": "G"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "issn-l": null, "volume": "25", "issue": null, "pages": "100457"}, "abstract": "Italy's severe COVID-19 outbreak was addressed by a lockdown that gradually increased in space, time and intensity. The effectiveness of the lockdown has not been precisely assessed with respect to the intensity of mobility restriction and the time until the outbreak receded.\r\n\r\nWe used processed mobile phone tracking data to measure mobility restriction, and related those data to the number of new SARS-CoV-2 positive cases detected on a daily base in the three most affected Italian regions, Lombardy, Veneto and Emilia-Romagna, from February 1 through April 6, 2020, when two subsequent lockdowns with increasing intensity were implemented by the Italian government.\r\n\r\nDuring the study period, mobility restriction was inversely related to the daily number of newly diagnosed SARS-CoV-2 positive cases only after the second, more effective lockdown, with a peak in the curve of diagnosed cases of infection occurring 14 to 18 days from lockdown in the three regions and 9 to 25 days in the included provinces. An effective reduction in transmission must have occurred nearly immediately after the tighter lockdown, given the lag time of around 10 days from asymptomatic infection to diagnosis. The period from lockdown to peak was shorter in the areas with the highest prevalence of the infection. This effect was seen within slightly more than one week in the most severely affected areas.\r\n\r\nIt appears that the less rigid lockdown led to an insufficient decrease in mobility to reverse an outbreak such as COVID-19. With a tighter lockdown, mobility decreased enough to bring down transmission promptly below the level needed to sustain the epidemic.\r\n\r\nNo funding sources have been used for this work.", "doi": "10.1016/j.eclinm.2020.100457", "pmid": "32838234", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(20)30201-7"}, {"db": "pii", "key": "100457"}, {"db": "pmc", "key": "PMC7355328"}], "notes": [], "created": "2020-12-07T10:32:00.513Z", "modified": "2022-11-10T07:23:24.584Z"}, {"entity": "publication", "iuid": "1ab8d8dc9a0c42f8925aafa2e839129f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ab8d8dc9a0c42f8925aafa2e839129f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ab8d8dc9a0c42f8925aafa2e839129f"}}, "title": "Investigation of a COVID-19 outbreak in Germany resulting from a single travel-associated primary case: a case series", "authors": [{"family": "B\u00f6hmer", "given": "Merle M", "initials": "MM"}, {"family": "Buchholz", "given": "Udo", "initials": "U"}, {"family": "Corman", "given": "Victor M", "initials": "VM"}, {"family": "Hoch", "given": "Martin", "initials": "M"}, {"family": "Katz", "given": "Katharina", "initials": "K"}, {"family": "Marosevic", "given": "Durdica V", "initials": "DV"}, {"family": "B\u00f6hm", "given": "Stefanie", "initials": "S"}, {"family": "Woudenberg", "given": "Tom", "initials": "T"}, {"family": "Ackermann", "given": "Nikolaus", "initials": "N"}, {"family": "Konrad", "given": "Regina", "initials": "R"}, {"family": "Eberle", "given": "Ute", "initials": "U"}, {"family": "Treis", "given": "Bianca", "initials": "B"}, {"family": "Dangel", "given": "Alexandra", "initials": "A"}, {"family": "Bengs", "given": "Katja", "initials": "K"}, {"family": "Fingerle", "given": "Volker", "initials": "V"}, {"family": "Berger", "given": "Anja", "initials": "A"}, {"family": "H\u00f6rmansdorfer", "given": "Stefan", "initials": "S"}, {"family": "Ippisch", "given": "Siegfried", "initials": "S"}, {"family": "Wicklein", "given": "Bernd", "initials": "B"}, {"family": "Grahl", "given": "Andreas", "initials": "A"}, {"family": "P\u00f6rtner", "given": "Kirsten", "initials": "K"}, {"family": "Muller", "given": "Nadine", "initials": "N"}, {"family": "Zeitlmann", "given": "Nadine", "initials": "N"}, {"family": "Boender", "given": "T Sonia", "initials": "TS"}, {"family": "Cai", "given": "Wei", "initials": "W"}, {"family": "Reich", "given": "Andreas", "initials": "A"}, {"family": "an der Heiden", "given": "Maria", "initials": "M"}, {"family": "Rexroth", "given": "Ute", "initials": "U"}, {"family": "Hamouda", "given": "Osamah", "initials": "O"}, {"family": "Schneider", "given": "Julia", "initials": "J"}, {"family": "Veith", "given": "Talitha", "initials": "T"}, {"family": "M\u00fchlemann", "given": "Barbara", "initials": "B"}, {"family": "W\u00f6lfel", "given": "Roman", "initials": "R"}, {"family": "Antwerpen", "given": "Markus", "initials": "M"}, {"family": "Walter", "given": "Mathias", "initials": "M"}, {"family": "Protzer", "given": "Ulrike", "initials": "U"}, {"family": "Liebl", "given": "Bernhard", "initials": "B"}, {"family": "Haas", "given": "Walter", "initials": "W"}, {"family": "Sing", "given": "Andreas", "initials": "A"}, {"family": "Drosten", "given": "Christian", "initials": "C"}, {"family": "Zapf", "given": "Andreas", "initials": "A"}], "type": "journal-article", "published": "2020-08-00", "journal": {"title": "The Lancet Infectious Diseases", "issn": "1473-3099", "volume": "20", "issue": "8", "pages": "920-928", "issn-l": null}, "abstract": "In December, 2019, the newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, causing COVID-19, a respiratory disease presenting with fever, cough, and often pneumonia. WHO has set the strategic objective to interrupt spread of SARS-CoV-2 worldwide. An outbreak in Bavaria, Germany, starting at the end of January, 2020, provided the opportunity to study transmission events, incubation period, and secondary attack rates.\n\nA case was defined as a person with SARS-CoV-2 infection confirmed by RT-PCR. Case interviews were done to describe timing of onset and nature of symptoms and to identify and classify contacts as high risk (had cumulative face-to-face contact with a confirmed case for \u226515 min, direct contact with secretions or body fluids of a patient with confirmed COVID-19, or, in the case of health-care workers, had worked within 2 m of a patient with confirmed COVID-19 without personal protective equipment) or low risk (all other contacts). High-risk contacts were ordered to stay at home in quarantine for 14 days and were actively followed up and monitored for symptoms, and low-risk contacts were tested upon self-reporting of symptoms. We defined fever and cough as specific symptoms, and defined a prodromal phase as the presence of non-specific symptoms for at least 1 day before the onset of specific symptoms. Whole genome sequencing was used to confirm epidemiological links and clarify transmission events where contact histories were ambiguous; integration with epidemiological data enabled precise reconstruction of exposure events and incubation periods. Secondary attack rates were calculated as the number of cases divided by the number of contacts, using Fisher's exact test for the 95% CIs.\n\nPatient 0 was a Chinese resident who visited Germany for professional reasons. 16 subsequent cases, often with mild and non-specific symptoms, emerged in four transmission generations. Signature mutations in the viral genome occurred upon foundation of generation 2, as well as in one case pertaining to generation 4. The median incubation period was 4\u00b70 days (IQR 2\u00b73-4\u00b73) and the median serial interval was 4\u00b70 days (3\u00b70-5\u00b70). Transmission events were likely to have occurred presymptomatically for one case (possibly five more), at the day of symptom onset for four cases (possibly five more), and the remainder after the day of symptom onset or unknown. One or two cases resulted from contact with a case during the prodromal phase. Secondary attack rates were 75\u00b70% (95% CI 19\u00b70-99\u00b70; three of four people) among members of a household cluster in common isolation, 10\u00b70% (1\u00b72-32\u00b70; two of 20) among household contacts only together until isolation of the patient, and 5\u00b71% (2\u00b76-8\u00b79; 11 of 217) among non-household, high-risk contacts.\n\nAlthough patients in our study presented with predominately mild, non-specific symptoms, infectiousness before or on the day of symptom onset was substantial. Additionally, the incubation period was often very short and false-negative tests occurred. These results suggest that although the outbreak was controlled, successful long-term and global containment of COVID-19 could be difficult to achieve.\n\nAll authors are employed and all expenses covered by governmental, federal state, or other publicly funded institutions.", "doi": "10.1016/s1473-3099(20)30314-5", "pmid": "32422201", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7228725"}, {"db": "pii", "key": "S1473-3099(20)30314-5"}], "notes": [], "created": "2020-12-10T08:57:10.569Z", "modified": "2023-06-19T15:24:24.557Z"}, {"entity": "publication", "iuid": "af81d5d1037f49c09189c3c0c55d609e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/af81d5d1037f49c09189c3c0c55d609e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/af81d5d1037f49c09189c3c0c55d609e"}}, "title": "Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity.", "authors": [{"family": "Guallar", "given": "Mar\u00eda Pilar", "initials": "MP"}, {"family": "Meiri\u00f1o", "given": "Rosa", "initials": "R"}, {"family": "Donat-Vargas", "given": "Carolina", "initials": "C"}, {"family": "Corral", "given": "Octavio", "initials": "O"}, {"family": "Jouv\u00e9", "given": "Nicol\u00e1s", "initials": "N"}, {"family": "Soriano", "given": "Vicente", "initials": "V"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": "97", "issue": null, "pages": "290-292"}, "abstract": "A relationship between the infecting dose and the risk of disease severity has not been demonstrated for SARS-CoV-2 infection. Here, we report three clusters of individuals that were potentially exposed to distinct inoculum in Madrid. Overall each group developed divergent clinical forms of COVID-19. Our data support that a greater viral inoculum at the time of SARS-CoV-2 exposure might determine a higher risk of severe COVID-19.", "doi": "10.1016/j.ijid.2020.06.035", "pmid": "32553720", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(20)30470-7"}, {"db": "pmc", "key": "PMC7293836"}], "notes": [], "created": "2020-12-09T07:48:44.715Z", "modified": "2021-02-26T08:45:48.582Z"}, {"entity": "publication", "iuid": "c1cd8bba32f3469cbe65a77299dc9595", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1cd8bba32f3469cbe65a77299dc9595.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1cd8bba32f3469cbe65a77299dc9595"}}, "title": "Inhalational volatile-based sedation for COVID-19 pneumonia and ARDS.", "authors": [{"family": "Jerath", "given": "Angela", "initials": "A"}, {"family": "Ferguson", "given": "Niall D", "initials": "ND"}, {"family": "Cuthbertson", "given": "Brian", "initials": "B"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "volume": "46", "issue": "8", "pages": "1563-1566", "issn-l": "0342-4642"}, "abstract": "Hospitals worldwide are experiencing a shortage in essential intravenous sedative medications. This is attributable to high number and high sedative needs of COVID-19 critical care patients with disruption of drug supply chains. Inhaled volatile anesthetic agents are an abundant resource and readily implementable solution for providing ICU sedation. Inhaled volatile agents may also provide important pulmonary benefits for COVID-19 patients with ARDS that could improve gas exchange and reduce time spent on a ventilator. We review the use of volatile agents, and provide a technical overview and algorithm for administering inhaled volatile-based sedation in ICUs.", "doi": "10.1007/s00134-020-06154-8", "pmid": "32588067", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-020-06154-8"}, {"db": "pmc", "key": "PMC7315695"}], "notes": [], "created": "2020-12-08T15:48:14.991Z", "modified": "2020-12-08T15:48:15.004Z"}, {"entity": "publication", "iuid": "9cf51abd932249898af01c24bd5289e3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9cf51abd932249898af01c24bd5289e3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9cf51abd932249898af01c24bd5289e3"}}, "title": "Impact of the COVID-19 pandemic on ongoing cardiovascular research projects: considerations and adaptations.", "authors": [{"family": "Van Bulck", "given": "Liesbet", "initials": "L"}, {"family": "Kovacs", "given": "Adrienne H", "initials": "AH"}, {"family": "Goossens", "given": "Eva", "initials": "E"}, {"family": "Luyckx", "given": "Koen", "initials": "K"}, {"family": "Jaarsma", "given": "Tiny", "initials": "T"}, {"family": "Str\u00f6mberg", "given": "Anna", "initials": "A"}, {"family": "Moons", "given": "Philip", "initials": "P"}], "type": "editorial", "published": "2020-08-00", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "volume": "19", "issue": "6", "pages": "465-468", "issn-l": null}, "abstract": null, "doi": "10.1177/1474515120926629", "pmid": "32418455", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-10T08:56:28.283Z", "modified": "2020-12-10T08:56:28.296Z"}, {"entity": "publication", "iuid": "137eb41ee24d46898ba5785cebd6f1df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/137eb41ee24d46898ba5785cebd6f1df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/137eb41ee24d46898ba5785cebd6f1df"}}, "title": "Hyperreninemia and low total body water may contribute to acute kidney injury in COVID-19 patients in intensive care.", "authors": [{"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "von Seth", "given": "Magnus", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "J Hypertens", "issn": "1473-5598", "issn-l": "0263-6352", "volume": "38", "issue": "8", "pages": "1613-1614"}, "abstract": "No abstract available", "doi": "10.1097/HJH.0000000000002531", "pmid": "32472780", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "NA", "key": "Provided in the article: biochemistry of patients in intensive care (N=9)", "description": null}], "notes": [], "created": "2020-10-30T11:42:00.648Z", "modified": "2021-02-26T08:45:02.849Z"}, {"entity": "publication", "iuid": "666b3cf7632f4444bc8e1b4aab6b02b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/666b3cf7632f4444bc8e1b4aab6b02b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/666b3cf7632f4444bc8e1b4aab6b02b4"}}, "title": "Global Survey on Pancreatic Surgery During the COVID-19 Pandemic.", "authors": [{"family": "Oba", "given": "Atsushi", "initials": "A"}, {"family": "Stoop", "given": "Thomas F", "initials": "TF"}, {"family": "L\u00f6hr", "given": "Matthias", "initials": "M"}, {"family": "Hackert", "given": "Thilo", "initials": "T"}, {"family": "Zyromski", "given": "Nicholas", "initials": "N"}, {"family": "Nealon", "given": "William H", "initials": "WH"}, {"family": "Unno", "given": "Michiaki", "initials": "M"}, {"family": "Schulick", "given": "Richard D", "initials": "RD"}, {"family": "Al-Musawi", "given": "Mohammed H", "initials": "MH"}, {"family": "Wu", "given": "Wenming", "initials": "W"}, {"family": "Zhao", "given": "Yupei", "initials": "Y"}, {"family": "Satoi", "given": "Sohei", "initials": "S"}, {"family": "Wolfgang", "given": "Christopher L", "initials": "CL"}, {"family": "Abu Hilal", "given": "Mohammad", "initials": "M"}, {"family": "Besselink", "given": "Marc G", "initials": "MG"}, {"family": "Del Chiaro", "given": "Marco", "initials": "M"}, {"family": "Pancreas Club, European Pancreatic Club, Chinese Pancreatic Surgery Association, European Consortium on Minimally Invasive Pancreatic Surgery, Study Group of Preoperative Therapy for Pancreatic Cancer, Study Group of Pancreatic Ductal Adenocarcinoma with Peritoneal Metastasis and International Study Group on Cystic Tumors of the Pancreas", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Ann Surg", "issn": "1528-1140", "volume": "272", "issue": "2", "pages": "e87-e93", "issn-l": null}, "abstract": "The aim of this study was to clarify the role of pancreatic surgery during the COVID-19 pandemic to optimize patients' and clinicians' safety and safeguard health care capacity.\n\nThe COVID-19 pandemic heavily impacts health care systems worldwide. Cancer patients appear to have an increased risk for adverse events when infected by COVID-19, but the inability to receive oncological care seems may be an even larger threat, particularly in case of pancreatic cancer.\n\nAn online survey was submitted to all members of seven international pancreatic associations and study groups, investigating the impact of the COVID-19 pandemic on pancreatic surgery using 21 statements (April, 2020). Consensus was defined as >80% agreement among respondents and moderate agreement as 60% to 80% agreement.\n\nA total of 337 respondents from 267 centers and 37 countries spanning 5 continents completed the survey. Most respondents were surgeons (n = 302, 89.6%) and working in an academic center (n = 286, 84.9%). The majority of centers (n = 166, 62.2%) performed less pancreatic surgery because of the COVID-19 pandemic, reducing the weekly pancreatic resection rate from 3 [interquartile range (IQR) 2-5] to 1 (IQR 0-2) (P < 0.001). Most centers screened for COVID-19 before pancreatic surgery (n = 233, 87.3%). Consensus was reached on 13 statements and 5 statements achieved moderate agreement.\n\nThis global survey elucidates the role of pancreatic surgery during the COVID-19 pandemic, regarding patient selection for the surgical and oncological treatment of pancreatic diseases to support clinical decision-making and creating a starting point for further discussion.", "doi": "10.1097/SLA.0000000000004006", "pmid": "32675507", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00000658-202008000-00027"}, {"db": "pmc", "key": "PMC7268883"}], "notes": [], "created": "2020-12-07T16:35:13.417Z", "modified": "2021-02-26T08:45:48.271Z"}, {"entity": "publication", "iuid": "19e27f15f057496f97f18f9b6d599e2e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19e27f15f057496f97f18f9b6d599e2e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19e27f15f057496f97f18f9b6d599e2e"}}, "title": "Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020.", "authors": [{"family": "Alm", "given": "Erik", "initials": "E"}, {"family": "Broberg", "given": "Eeva K", "initials": "EK"}, {"family": "Connor", "given": "Thomas", "initials": "T"}, {"family": "Hodcroft", "given": "Emma B", "initials": "EB"}, {"family": "Komissarov", "given": "Andrey B", "initials": "AB"}, {"family": "Maurer-Stroh", "given": "Sebastian", "initials": "S"}, {"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "Neher", "given": "Richard A", "initials": "RA"}, {"family": "O'Toole", "given": "\u00c1ine", "initials": "\u00c1"}, {"family": "Pereyaslov", "given": "Dmitriy", "initials": "D"}, {"family": "WHO European Region sequencing laboratories and GISAID EpiCoV group", "given": "", "initials": ""}, {"family": "WHO European Region sequencing laboratories and GISAID EpiCoV group*", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "32", "issn-l": null}, "abstract": "We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation, compare the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2.", "doi": "10.2807/1560-7917.ES.2020.25.32.2001410", "pmid": "32794443", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7427299"}], "notes": [], "created": "2020-12-07T13:23:05.531Z", "modified": "2021-02-26T08:46:12.957Z"}, {"entity": "publication", "iuid": "23cc455881f449c0a93ce9cff278ca53", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23cc455881f449c0a93ce9cff278ca53.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23cc455881f449c0a93ce9cff278ca53"}}, "title": "Flexibility and safety in times of coronavirus disease 2019 (COVID-19): Implications for nurses and allied professionals in cardiology.", "authors": [{"family": "Jaarsma", "given": "Tiny", "initials": "T"}, {"family": "van der Wal", "given": "Martje", "initials": "M"}, {"family": "Hinterbuchner", "given": "Lynne", "initials": "L"}, {"family": "K\u00f6berich", "given": "Stefan", "initials": "S"}, {"family": "Lie", "given": "Irene", "initials": "I"}, {"family": "Str\u00f6mberg", "given": "Anna", "initials": "A"}], "type": "editorial", "published": "2020-08-00", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "volume": "19", "issue": "6", "pages": "462-464", "issn-l": null}, "abstract": null, "doi": "10.1177/1474515120921027", "pmid": "32323572", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7441330"}], "notes": [], "created": "2020-12-09T14:53:50.944Z", "modified": "2020-12-09T14:53:50.954Z"}, {"entity": "publication", "iuid": "80bed42b5a9b45b296b0ca6afd771097", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/80bed42b5a9b45b296b0ca6afd771097.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/80bed42b5a9b45b296b0ca6afd771097"}}, "title": "Exercise in the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) era: A Question and Answer session with the experts Endorsed by the section of Sports Cardiology & Exercise of the European Association of Preventive Cardiology (EAPC).", "authors": [{"family": "Bhatia", "given": "Raghav T", "initials": "RT"}, {"family": "Marwaha", "given": "Sarandeep", "initials": "S"}, {"family": "Malhotra", "given": "Aneil", "initials": "A"}, {"family": "Iqbal", "given": "Zafar", "initials": "Z"}, {"family": "Hughes", "given": "Christopher", "initials": "C"}, {"family": "B\u00f6rjesson", "given": "Mats", "initials": "M"}, {"family": "Niebauer", "given": "Josef", "initials": "J"}, {"family": "Pelliccia", "given": "Antonio", "initials": "A"}, {"family": "Schmied", "given": "Christian", "initials": "C"}, {"family": "Serratosa", "given": "Luis", "initials": "L"}, {"family": "Papadakis", "given": "Michael", "initials": "M"}, {"family": "Sharma", "given": "Sanjay", "initials": "S"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Eur J Prev Cardiol", "issn": "2047-4881", "volume": "27", "issue": "12", "pages": "1242-1251", "issn-l": null}, "abstract": "Regular exercise has multiple benefits for physical and mental health, including the body's ability to combat infections. The current COVID-19 pandemic and the social distancing measures employed to curtail the impact of the infection are likely to reduce the amount of usual physical activity being performed by most individuals, including habitual exercisers. The uncertainties relating to the impact of the SARS-CoV-2 virus on the heart may cause increased anxiety, particularly in athletes who need to sustain a vigorous exercise regime in order to maintain their skills and fitness in preparation for return to competition after a short re-training period. The aim of this document is to provide practical answers to pertinent questions being posed by the sporting community, in an attempt to offer reassurance, promote safe participation in exercise during as well as after the COVID-19 pandemic and provide a framework of management for physicians caring for athletes.", "doi": "10.1177/2047487320930596", "pmid": "32475157", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-09T10:58:22.606Z", "modified": "2020-12-09T10:58:22.628Z"}, {"entity": "publication", "iuid": "336a049f34ae4df0a98f6b91d351915c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/336a049f34ae4df0a98f6b91d351915c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/336a049f34ae4df0a98f6b91d351915c"}}, "title": "European Task Force on Contact Dermatitis statement on coronavirus disease-19 (COVID-19) outbreak and the risk of adverse cutaneous reactions.", "authors": [{"family": "Balato", "given": "A", "initials": "A"}, {"family": "Ayala", "given": "F", "initials": "F"}, {"family": "Bruze", "given": "M", "initials": "M"}, {"family": "Crepy", "given": "M-N", "initials": "MN"}, {"family": "Gon\u00e7alo", "given": "M", "initials": "M"}, {"family": "Johansen", "given": "J", "initials": "J"}, {"family": "John", "given": "S M", "initials": "SM"}, {"family": "Pigatto", "given": "P", "initials": "P"}, {"family": "Raimondo", "given": "A", "initials": "A"}, {"family": "Rustemeyer", "given": "T", "initials": "T"}, {"family": "Schuttelaar", "given": "M-L A", "initials": "MA"}, {"family": "Svedman", "given": "C", "initials": "C"}, {"family": "Aerts", "given": "O", "initials": "O"}, {"family": "Uter", "given": "W", "initials": "W"}, {"family": "Wilkinson", "given": "M", "initials": "M"}, {"family": "Gimenez-Arnau", "given": "A", "initials": "A"}], "type": "letter", "published": "2020-08-00", "journal": {"title": "J Eur Acad Dermatol Venereol", "issn": "1468-3083", "volume": "34", "issue": "8", "pages": "e353-e354", "issn-l": null}, "abstract": null, "doi": "10.1111/jdv.16557", "pmid": "32356382", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-10T07:17:53.057Z", "modified": "2020-12-10T07:17:53.068Z"}, {"entity": "publication", "iuid": "e3aae2291569457e80d5f36dff065efc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3aae2291569457e80d5f36dff065efc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3aae2291569457e80d5f36dff065efc"}}, "title": "Estimation of the COVID-19 burden in Egypt through exported case detection.", "authors": [{"family": "Tuite", "given": "Ashleigh R", "initials": "AR"}, {"family": "Ng", "given": "Victoria", "initials": "V"}, {"family": "Rees", "given": "Erin", "initials": "E"}, {"family": "Fisman", "given": "David", "initials": "D"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Khan", "given": "Kamran", "initials": "K"}, {"family": "Bogoch", "given": "Isaac I", "initials": "II"}], "type": "letter", "published": "2020-08-00", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "volume": "20", "issue": "8", "pages": "894", "issn-l": null}, "abstract": null, "doi": "10.1016/S1473-3099(20)30233-4", "pmid": "32222162", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(20)30233-4"}, {"db": "pmc", "key": "PMC7195316"}], "notes": [], "created": "2020-12-10T08:58:07.204Z", "modified": "2020-12-10T08:58:07.215Z"}, {"entity": "publication", "iuid": "41aacb23f79843de9c9fd92f17eadda4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41aacb23f79843de9c9fd92f17eadda4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41aacb23f79843de9c9fd92f17eadda4"}}, "title": "Estimation of COVID-19 burden in Egypt - Authors' reply.", "authors": [{"family": "Tuite", "given": "Ashleigh R", "initials": "AR"}, {"family": "Ng", "given": "Victoria", "initials": "V"}, {"family": "Rees", "given": "Erin", "initials": "E"}, {"family": "Fisman", "given": "David", "initials": "D"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Khan", "given": "Kamran", "initials": "K"}, {"family": "Bogoch", "given": "Isaac I", "initials": "II"}], "type": "letter", "published": "2020-08-00", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "volume": "20", "issue": "8", "pages": "897-898", "issn-l": null}, "abstract": null, "doi": "10.1016/S1473-3099(20)30326-1", "pmid": "32353344", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(20)30326-1"}, {"db": "pmc", "key": "PMC7185943"}], "notes": [], "created": "2020-12-10T07:16:28.263Z", "modified": "2020-12-10T07:16:28.272Z"}, {"entity": "publication", "iuid": "8b7103dffee443d1b2b330f2beec8184", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b7103dffee443d1b2b330f2beec8184.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b7103dffee443d1b2b330f2beec8184"}}, "title": "Delivery of hepato-pancreato-biliary surgery during the COVID-19 pandemic: an European-African Hepato-Pancreato-Biliary Association (E-AHPBA) cross-sectional survey.", "authors": [{"family": "Balakrishnan", "given": "Anita", "initials": "A"}, {"family": "Lesurtel", "given": "Mickael", "initials": "M"}, {"family": "Siriwardena", "given": "Ajith K", "initials": "AK"}, {"family": "Heinrich", "given": "Stefan", "initials": "S"}, {"family": "Serrablo", "given": "Alejandro", "initials": "A"}, {"family": "Besselink", "given": "Marc G H", "initials": "MGH"}, {"family": "Erkan", "given": "Mert", "initials": "M"}, {"family": "Andersson", "given": "Bodil", "initials": "B"}, {"family": "Polak", "given": "Wojciech G", "initials": "WG"}, {"family": "Laurenzi", "given": "Andrea", "initials": "A"}, {"family": "Olde Damink", "given": "Stefan W M", "initials": "SWM"}, {"family": "Berrevoet", "given": "Frederik", "initials": "F"}, {"family": "Frigerio", "given": "Isabella", "initials": "I"}, {"family": "Ramia", "given": "Jose M", "initials": "JM"}, {"family": "Gallagher", "given": "Thomas K", "initials": "TK"}, {"family": "Warner", "given": "Susanne", "initials": "S"}, {"family": "Shrikhande", "given": "Shailesh V", "initials": "SV"}, {"family": "Adam", "given": "Rene", "initials": "R"}, {"family": "Smith", "given": "Martin D", "initials": "MD"}, {"family": "Conlon", "given": "Kevin C", "initials": "KC"}, {"family": "E-AHPBA Scientific and Research Committee", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "HPB (Oxford)", "issn": "1477-2574", "volume": "22", "issue": "8", "pages": "1128-1134", "issn-l": null}, "abstract": "The extent of the COVID-19 pandemic and the resulting response has varied globally. The European and African Hepato-Pancreato-Biliary Association (E-AHPBA), the premier representative body for practicing HPB surgeons in Europe and Africa, conducted this survey to assess the impact of COVID-19 on HPB surgery.\n\nAn online survey was disseminated to all E-AHPBA members to assess the effects of the pandemic on unit capacity, management of HPB cancers, use of COVID-19 screening and other aspects of service delivery.\n\nOverall, 145 (25%) members responded. Most units, particularly in COVID-high countries (>100,000 cases) reported insufficient critical care capacity and reduced HPB operating sessions compared to COVID-low countries. Delayed access to cancer surgery necessitated alternatives including increased neoadjuvant chemotherapy for pancreatic cancer and colorectal liver metastases, and locoregional treatments for hepatocellular carcinoma. Other aspects of service delivery including COVID-19 screening and personal protective equipment varied between units and countries.\n\nThis study demonstrates that the COVID-19 pandemic has had a profound adverse impact on the delivery of HPB cancer care across the continents of Europe and Africa. The findings illustrate the need for safe resumption of cancer surgery in a \"new\" normal world with screening of patients and staff for COVID-19.", "doi": "10.1016/j.hpb.2020.05.012", "pmid": "32565039", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S1365-182X(20)31040-6"}, {"db": "pmc", "key": "PMC7284265"}], "notes": [], "created": "2020-12-08T16:33:29.400Z", "modified": "2021-02-26T08:46:13.366Z"}, {"entity": "publication", "iuid": "311ba3cc55dd4405af16b70d0fa700b7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/311ba3cc55dd4405af16b70d0fa700b7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/311ba3cc55dd4405af16b70d0fa700b7"}}, "title": "Delivering healthcare remotely to cardiovascular patients during COVID-19 : A rapid review of the evidence.", "authors": [{"family": "Neubeck", "given": "Lis", "initials": "L"}, {"family": "Hansen", "given": "Tina", "initials": "T"}, {"family": "Jaarsma", "given": "Tiny", "initials": "T"}, {"family": "Klompstra", "given": "Leonie", "initials": "L"}, {"family": "Gallagher", "given": "Robyn", "initials": "R"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "volume": "19", "issue": "6", "pages": "486-494", "issn-l": null}, "abstract": "Although attention is focused on addressing the acute situation created by the COVID-19 illness, it is imperative to continue our efforts to prevent cardiovascular morbidity and mortality, particularly during a period of prolonged social isolation which may limit physical activity, adversely affect mental health and reduce access to usual care. One option may be to deliver healthcare interventions remotely through digital healthcare solutions. Therefore, the aim of this paper is to bring together the evidence for remote healthcare during a quarantine situation period to support people living with cardiovascular disease during COVID-19 isolation.\n\nThe PubMed, CINAHL and Google Scholar were searched using telehealth OR digital health OR mHealth OR eHealth OR mobile apps AND COVID-19 OR quarantine search terms. We also searched for literature relating to cardiovascular disease AND quarantine.\n\nThe literature search identified 45 potentially relevant publications, out of which nine articles were included. Three overarching themes emerged from this review: (1) preparing the workforce and ensuring reimbursement for remote healthcare, (2) supporting mental and physical health and (3) supporting usual care.\n\nTo support people living with cardiovascular disease during COVID-19 isolation and to mitigate the effects of quarantine and adverse effect on mental and physical well-being, we should offer remote healthcare and provide access to their usual care.", "doi": "10.1177/1474515120924530", "pmid": "32380858", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-30T09:10:05.652Z", "modified": "2020-11-30T09:10:05.676Z"}, {"entity": "publication", "iuid": "9d81995f5daf410da34016e079e9bd0a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9d81995f5daf410da34016e079e9bd0a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9d81995f5daf410da34016e079e9bd0a"}}, "title": "Dealing with sleep problems during home confinement due to the COVID-19 outbreak: Practical recommendations from a task force of the European CBT-I Academy.", "authors": [{"family": "Altena", "given": "Ellemarije", "initials": "E"}, {"family": "Baglioni", "given": "Chiara", "initials": "C"}, {"family": "Espie", "given": "Colin A", "initials": "CA"}, {"family": "Ellis", "given": "Jason", "initials": "J"}, {"family": "Gavriloff", "given": "Dimitri", "initials": "D"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Schlarb", "given": "Angelika", "initials": "A"}, {"family": "Frase", "given": "Lukas", "initials": "L"}, {"family": "Jernel\u00f6v", "given": "Susanna", "initials": "S"}, {"family": "Riemann", "given": "Dieter", "initials": "D"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "J Sleep Res", "issn": "1365-2869", "volume": "29", "issue": "4", "pages": "e13052", "issn-l": "0962-1105"}, "abstract": "Editorial\r\n\r\nIn the current global home confinement situation due to the COVID-19 outbreak, most individuals are exposed to an unprecedented stressful situation of unknown duration. This may not only increase daytime stress, anxiety and depression levels, but also disrupt sleep. Importantly, because of the fundamental role that sleep plays in emotion regulation, sleep disturbance can have direct consequences upon next day emotional functioning. In this paper, we summarize what is known about the stress-sleep link and confinement as well as effective insomnia treatment. We discuss those effects of the current home confinement situation that can disrupt sleep but also those that could benefit sleep quality. We suggest adaptions of cognitive behavioural therapy elements that are feasible to implement for those facing changed work schedules and requirements, those with health anxiety and those handling childcare and home-schooling, whilst also recognizing the general limitations imposed on physical exercise and social interaction. Managing sleep problems as best as possible during home confinement can limit stress and possibly prevent disruptions of social relationships.", "doi": "10.1111/jsr.13052", "pmid": "32246787", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-25T07:26:15.028Z", "modified": "2020-11-30T15:56:39.059Z"}, {"entity": "publication", "iuid": "2ab907e81c514e46a3d203d801cff0ad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ab907e81c514e46a3d203d801cff0ad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ab907e81c514e46a3d203d801cff0ad"}}, "title": "D-dimer in patients infected with COVID-19 and suspected pulmonary embolism.", "authors": [{"family": "Garcia-Oliv\u00e9", "given": "Ignasi", "initials": "I"}, {"family": "Sintes", "given": "Helena", "initials": "H"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Abad Capa", "given": "Jorge", "initials": "J"}, {"family": "Rosell", "given": "Antoni", "initials": "A"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Respir Med", "issn": "1532-3064", "volume": "169", "issue": null, "pages": "106023", "issn-l": "0954-6111"}, "abstract": "To analyze the risk factors for pulmonary embolism (PE) in patients infected with COVID-19.\n\nWe conducted an observational, retrospective study. Patients with severe infection with COVID-19 and suspected PE were included.\n\nPatients with higher levels of D-dimer and those requiring intubation were at a higher risk of developing PE. Higher D-dimer levels were associated with a greater probability of PE 3, 6, 9 and 12 days after determining D-dimer levels with an OR of 1.7, 2.0, 2.4 and 2.4, respectively.\n\nIn conclusion, patients infected with COVID-19 requiring OTI with higher levels of D-dimer have an increased risk of developing PE.", "doi": "10.1016/j.rmed.2020.106023", "pmid": "32454268", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S0954-6111(20)30163-3"}, {"db": "pmc", "key": "PMC7219417"}], "notes": [], "created": "2020-11-25T09:15:41.624Z", "modified": "2021-02-26T08:45:02.911Z"}, {"entity": "publication", "iuid": "fc7182e6cfb14b3687e06c6a096d218f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc7182e6cfb14b3687e06c6a096d218f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc7182e6cfb14b3687e06c6a096d218f"}}, "title": "Children are unlikely to be the main drivers of the COVID-19 pandemic - A systematic review.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "volume": "109", "issue": "8", "pages": "1525-1530", "issn-l": null}, "abstract": "Many countries have closed schools and kindergartens to minimise COVID-19, but the role that children play in disease transmission is unclear.\r\n\r\nA systematic literature review of the MEDLINE and EMBASE databases and medRxiv/bioRxiv preprint servers to 11 May 2020 identified published and unpublished papers on COVID-19 transmission by children.\r\n\r\nWe identified 700 scientific papers and letters and 47 full texts were studied in detail. Children accounted for a small fraction of COVID-19 cases and mostly had social contacts with peers or parents, rather than older people at risk of severe disease. Data on viral loads were scarce, but indicated that children may have lower levels than adults, partly because they often have fewer symptoms, and this should decrease the transmission risk. Household transmission studies showed that children were rarely the index case and case studies suggested that children with COVID-19 seldom caused outbreaks. However, it is highly likely that children can transmit the SARS-COV-2 virus, which causes COVID-19, and even asymptomatic children can have viral loads.\r\n\r\nChildren are unlikely to be the main drivers of the pandemic. Opening up schools and kindergartens is unlikely to impact COVID-19 mortality rates in older people.", "doi": "10.1111/apa.15371", "pmid": "32430964", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-04T15:37:40.145Z", "modified": "2020-11-26T12:12:34.222Z"}, {"entity": "publication", "iuid": "4516da93170f4a63955ab4a4014f3836", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4516da93170f4a63955ab4a4014f3836.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4516da93170f4a63955ab4a4014f3836"}}, "title": "COVID-19 and neurointerventional service worldwide: a survey of the European Society of Minimally Invasive Neurological Therapy (ESMINT), the Society of NeuroInterventional Surgery (SNIS), the Sociedad Iberolatinoamericana de Neuroradiologia Diagnostica y Terapeutica (SILAN), the Society of Vascular and Interventional Neurology (SVIN), and the World Federation of Interventional and Therapeutic Neuroradiology (WFITN).", "authors": [{"family": "Fiehler", "given": "Jens", "initials": "J"}, {"family": "Brouwer", "given": "Patrick", "initials": "P"}, {"family": "D\u00edaz", "given": "Carlos", "initials": "C"}, {"family": "Hirsch", "given": "Joshua A", "initials": "JA"}, {"family": "Kulcsar", "given": "Zsolt", "initials": "Z"}, {"family": "Liebeskind", "given": "David", "initials": "D"}, {"family": "Linfante", "given": "Italo", "initials": "I"}, {"family": "Lylyk", "given": "Pedro", "initials": "P"}, {"family": "Mack", "given": "William J", "initials": "WJ"}, {"family": "Milburn", "given": "James", "initials": "J"}, {"family": "Nogueira", "given": "Raul", "initials": "R"}, {"family": "Orbach", "given": "Darren B", "initials": "DB"}, {"family": "Pumar", "given": "Jos\u00e9 Manuel Manuel", "initials": "JMM"}, {"family": "Tanaka", "given": "Michihiro", "initials": "M"}, {"family": "Taylor", "given": "Allan", "initials": "A"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "J Neurointerv Surg", "issn": "1759-8486", "volume": "12", "issue": "8", "pages": "726-730", "issn-l": "1759-8478"}, "abstract": "This survey was focused on the provision of neurointerventional services, the current practices of managing patients under COVID-19 conditions, and the expectations for the future.\n\nInvitations for this survey were sent out as a collaborative effort of the European Society of Minimally Invasive Neurological Therapy (ESMINT), the Society of NeuroInterventional Surgery (SNIS), the Sociedad Iberolatinoamericana de Neuroradiologia Diagnostica y Terapeutica (SILAN), the Society of Vascular and Interventional Neurology (SVIN), and the World Federation of Interventional and Therapeutic Neuroradiology (WFITN).\n\nOverall, 475 participants from 61 countries responded (six from Africa (1%), 81 from Asia (17%), 156 from Europe (33%), 53 from Latin America (11%), and 172 from North America (11%)). The majority of participants (96%) reported being able to provide emergency services, though 26% of these reported limited resources. A decrease in emergency procedures was reported by 69% of participants (52% in ischemic and hemorrhagic stroke, 11% ischemic, and 6% hemorrhagic stroke alone). Only 4% reported an increase in emergency cases. The emerging need for social distancing and the rapid adoption of remote communication was reflected in the interest in establishing case discussion forums (43%), general online forums (37%), and access to angio video streaming for live mentoring and support (33%).\n\nNeurointerventional emergency services are available in almost all centers, while the number of emergency patients is markedly decreased. Half of the participants have abandoned neurointerventions in non-emergent situations. There are considerable variations in the management of neurointerventions and in the expectations for the future.", "doi": "10.1136/neurintsurg-2020-016349", "pmid": "32546635", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "neurintsurg-2020-016349"}, {"db": "pmc", "key": "PMC7316120"}], "notes": [], "created": "2020-12-09T07:51:50.699Z", "modified": "2021-02-26T08:45:02.973Z"}, {"entity": "publication", "iuid": "a7cea9e2b86b45dc86bb5fd882d4aff0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7cea9e2b86b45dc86bb5fd882d4aff0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7cea9e2b86b45dc86bb5fd882d4aff0"}}, "title": "Building an international consortium for tracking coronavirus health status.", "authors": [{"family": "Segal", "given": "Eran", "initials": "E"}, {"family": "Zhang", "given": "Feng", "initials": "F"}, {"family": "Lin", "given": "Xihong", "initials": "X"}, {"family": "King", "given": "Gary", "initials": "G"}, {"family": "Shalem", "given": "Ophir", "initials": "O"}, {"family": "Shilo", "given": "Smadar", "initials": "S"}, {"family": "Allen", "given": "William E", "initials": "WE"}, {"family": "Alquaddoomi", "given": "Faisal", "initials": "F"}, {"family": "Altae-Tran", "given": "Han", "initials": "H"}, {"family": "Anders", "given": "Simon", "initials": "S"}, {"family": "Balicer", "given": "Ran", "initials": "R"}, {"family": "Bauman", "given": "Tal", "initials": "T"}, {"family": "Bonilla", "given": "Ximena", "initials": "X"}, {"family": "Booman", "given": "Gisel", "initials": "G"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "Cohen", "given": "Ori", "initials": "O"}, {"family": "Coletti", "given": "Silvano", "initials": "S"}, {"family": "Davidson", "given": "Natalie", "initials": "N"}, {"family": "Dor", "given": "Yuval", "initials": "Y"}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Elemento", "given": "Olivier", "initials": "O"}, {"family": "Evans", "given": "Georgina", "initials": "G"}, {"family": "Ewels", "given": "Phil", "initials": "P"}, {"family": "Gale", "given": "Joshua", "initials": "J"}, {"family": "Gavrieli", "given": "Amir", "initials": "A"}, {"family": "Geiger", "given": "Benjamin", "initials": "B"}, {"family": "Grad", "given": "Yonatan H", "initials": "YH"}, {"family": "Greene", "given": "Casey S", "initials": "CS"}, {"family": "Hajirasouliha", "given": "Iman", "initials": "I"}, {"family": "Jerala", "given": "Roman", "initials": "R"}, {"family": "Kahles", "given": "Andre", "initials": "A"}, {"family": "Kallioniemi", "given": "Olli", "initials": "O"}, {"family": "Keshet", "given": "Ayya", "initials": "A"}, {"family": "Kocarev", "given": "Ljupco", "initials": "L"}, {"family": "Landua", "given": "Gregory", "initials": "G"}, {"family": "Meir", "given": "Tomer", "initials": "T"}, {"family": "Muller", "given": "Aline", "initials": "A"}, {"family": "Nguyen", "given": "Long H", "initials": "LH"}, {"family": "Oresic", "given": "Matej", "initials": "M"}, {"family": "Ovchinnikova", "given": "Svetlana", "initials": "S"}, {"family": "Peterson", "given": "Hedi", "initials": "H"}, {"family": "Prodanova", "given": "Jana", "initials": "J"}, {"family": "Rajagopal", "given": "Jay", "initials": "J"}, {"family": "R\u00e4tsch", "given": "Gunnar", "initials": "G"}, {"family": "Rossman", "given": "Hagai", "initials": "H"}, {"family": "Rung", "given": "Johan", "initials": "J"}, {"family": "Sboner", "given": "Andrea", "initials": "A"}, {"family": "Sigaras", "given": "Alexandros", "initials": "A"}, {"family": "Spector", "given": "Tim", "initials": "T"}, {"family": "Steinherz", "given": "Ron", "initials": "R"}, {"family": "Stevens", "given": "Irene", "initials": "I"}, {"family": "Vilo", "given": "Jaak", "initials": "J"}, {"family": "Wilmes", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "volume": "26", "issue": "8", "pages": "1161-1165", "issn-l": "1078-8956"}, "abstract": null, "doi": "10.1038/s41591-020-0929-x", "pmid": "32488218", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-020-0929-x"}], "notes": [], "created": "2020-11-19T19:23:03.049Z", "modified": "2020-11-19T19:23:03.069Z"}, {"entity": "publication", "iuid": "023eb43b041b4e50be5765fade3a9d5e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/023eb43b041b4e50be5765fade3a9d5e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/023eb43b041b4e50be5765fade3a9d5e"}}, "title": "Assessing the psychological response to the COVID-19: A response to Bitan et al. \"Fear of COVID-19 scale: Psychometric characteristics, reliability and validity in the Israeli population\".", "authors": [{"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}], "type": "letter", "published": "2020-08-00", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "volume": "290", "issue": null, "pages": "113127", "issn-l": null}, "abstract": null, "doi": "10.1016/j.psychres.2020.113127", "pmid": "32502825", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(20)31547-X"}, {"db": "pmc", "key": "PMC7255140"}], "notes": [], "created": "2020-12-09T10:35:34.375Z", "modified": "2020-12-09T10:35:34.397Z"}, {"entity": "publication", "iuid": "11aa61844aa54c8fb17c8c1c81416cae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/11aa61844aa54c8fb17c8c1c81416cae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/11aa61844aa54c8fb17c8c1c81416cae"}}, "title": "Symptom Relief Is Possible in Elderly Dying COVID-19 Patients: A National Register Study.", "authors": [{"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "Bergstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Staffan", "initials": "S"}], "type": "journal article", "published": "2020-07-31", "journal": {"title": "J Palliat Med", "issn": "1557-7740", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Increasing numbers of people dying from COVID-19 are reported, but data are lacking on the way they die. Background: To study symptoms and symptom relief during the last week of life, comparing nursing homes with hospitals. Objective: The Swedish Register of Palliative Care with national coverage was used. Breakthrough symptoms were registered as Yes/No. Symptom relief was recorded on a 3-grade scale as Design: complete-partial-no relief. All deaths in COVID-19 were contrasted to deaths in a reference population (deaths 2019). Deaths at nursing homes were compared with deaths in hospitals. All deaths in hospitals or nursing homes (Setting and Subjects: n = 490) were analyzed. Deaths in other settings (specialized palliative care wards [n = 11], in palliative home care [n = 2], or in their own homes [n = 8]) were excluded (n = 21). Only patients with expected deaths (n = 390) were entered in the final analysis. Breathlessness as a breakthrough symptom was more common in COVID-19 patients than in the 2019 reference population (Results: p < 0.001) and relief of breathlessness, as well as anxiety, delirium, and death rattles was less successful in COVID-19 patients (p < 0.05 to p < 0.01 in different comparisons). Patients were older in nursing homes than in hospitals (86.6 years vs. 80.9 years, p < 0.001) and more often female (48% vs. 34%, p < 0.001). Breakthrough of breathlessness was much more frequently reported in hospital settings than in nursing homes, 73% versus 35% (p < 0.0001), and complete relief was more rarely possible in hospitals, 20% versus 42% (p < 0.01). The proportion of partial relief+complete relief was comparable, 92% versus 95% (ns). Also, anxiety and pain were more often completely relieved in nursing homes (p < 0.01 in both comparisons). The lower symptom prevalence in nursing homes may be explained by elderly frail residents dying already in the first phase of the COVID-19 disease, before acute respiratory distress syndrome develops.Conclusion:", "doi": "10.1089/jpm.2020.0249", "pmid": "32746685", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-07T16:02:24.617Z", "modified": "2022-11-10T07:29:58.676Z"}, {"entity": "publication", "iuid": "afa38fbb53ff4312b9b378bee719af74", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/afa38fbb53ff4312b9b378bee719af74.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/afa38fbb53ff4312b9b378bee719af74"}}, "title": "Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories", "authors": [{"family": "Su", "given": "Yapeng", "initials": "Y"}, {"family": "Chen", "given": "Daniel", "initials": "D"}, {"family": "Lausted", "given": "Christopher", "initials": "C"}, {"family": "Yuan", "given": "Dan", "initials": "D"}, {"family": "Choi", "given": "Jongchan", "initials": "J"}, {"family": "Dai", "given": "Cheng", "initials": "C"}, {"family": "Voillet", "given": "Valentin", "initials": "V"}, {"family": "Scherler", "given": "Kelsey", "initials": "K"}, {"family": "Troisch", "given": "Pamela", "initials": "P"}, {"family": "Duvvuri", "given": "Venkata R", "initials": "VR"}, {"family": "Baloni", "given": "Priyanka", "initials": "P"}, {"family": "Qin", "given": "Guangrong", "initials": "G"}, {"family": "Smith", "given": "Brett", "initials": "B"}, {"family": "Kornilov", "given": "Sergey", "initials": "S"}, {"family": "Rostomily", "given": "Clifford", "initials": "C"}, {"family": "Xu", "given": "Alex", "initials": "A"}, {"family": "Li", "given": "Jing", "initials": "J"}, {"family": "Dong", "given": "Shen", "initials": "S"}, {"family": "Rothchild", "given": "Alissa", "initials": "A"}, {"family": "Zhou", "given": "Jing", "initials": "J"}, {"family": "Murray", "given": "Kim", "initials": "K"}, {"family": "Edmark", "given": "Rick", "initials": "R"}, {"family": "Hong", "given": "Sunga", "initials": "S"}, {"family": "Jones", "given": "Lesley", "initials": "L"}, {"family": "Zhou", "given": "Yong", "initials": "Y"}, {"family": "Roper", "given": "Ryan", "initials": "R"}, {"family": "Mackay", "given": "Sean", "initials": "S"}, {"family": "O\u2019Mahony", "given": "D Shane", "initials": "DS"}, {"family": "Dale", "given": "Christopher R", "initials": "CR"}, {"family": "Wallick", "given": "Julie A", "initials": "JA"}, {"family": "Algren", "given": "Heather A", "initials": "HA"}, {"family": "Michael", "given": "Zager A", "initials": "ZA"}, {"family": "Magis", "given": "Andrew", "initials": "A"}, {"family": "Wei", "given": "Wei", "initials": "W"}, {"family": "Price", "given": "Nathan D", "initials": "ND"}, {"family": "Huang", "given": "Sui", "initials": "S"}, {"family": "Subramanian", "given": "Naeha", "initials": "N"}, {"family": "Wang", "given": "Kai", "initials": "K"}, {"family": "Hadlock", "given": "Jennifer", "initials": "J"}, {"family": "Hood", "given": "Leroy", "initials": "L"}, {"family": "Aderem", "given": "Alan", "initials": "A"}, {"family": "Bluestone", "given": "Jeffrey A", "initials": "JA"}, {"family": "Lanier", "given": "Lewis L", "initials": "LL"}, {"family": "Greenberg", "given": "Phil", "initials": "P"}, {"family": "Gottardo", "given": "Raphael", "initials": "R"}, {"family": "Davis", "given": "Mark M", "initials": "MM"}, {"family": "Goldman", "given": "Jason D", "initials": "JD"}, {"family": "Heath", "given": "James R", "initials": "JR"}, {"family": "None", "given": "", "initials": ""}], "type": "posted-content", "published": "2020-07-28", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.07.27.224063", "pmid": null, "labels": {"Type: Preprint": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "ArrayExpress", "key": "https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-9357/samples/", "description": "Processed data on samples and derived array files are available on ArrayExpress"}, {"db": "ISB COVID-19 Data Explorer", "key": "https://atlas.fredhutch.org/isb/covid/", "description": "Data integrated for further visualisation and analysis"}, {"db": "NA", "key": "pseudonymized RNA sequencing data available upon request from corresponding author (Due to potential risk of de-identification)", "description": null}], "notes": [], "created": "2021-01-08T08:58:17.158Z", "modified": "2021-11-18T08:28:15.341Z"}, {"entity": "publication", "iuid": "47b56a3f9d6546dc935a3bdbdd4b2315", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47b56a3f9d6546dc935a3bdbdd4b2315.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47b56a3f9d6546dc935a3bdbdd4b2315"}}, "title": "Importance of Inclusion of Pregnant and Breastfeeding Women in COVID-19 Therapeutic Trials.", "authors": [{"family": "LaCourse", "given": "Sylvia", "initials": "S"}, {"family": "John-Stewart", "given": "Grace", "initials": "G"}, {"family": "Adams Waldorf", "given": "Kristina M", "initials": "KM"}], "type": "journal article", "published": "2020-07-28", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "volume": "71", "issue": "15", "pages": "879-881", "issn-l": "1058-4838"}, "abstract": "Investigators are employing unprecedented innovation in the design of clinical trials to rapidly and rigorously assess potentially promising therapies for coronavirus disease 2019 (COVID-19); this is in stark contrast to the continued near-universal regressive practice of exclusion of pregnant and breastfeeding women from these trials. The few trials that allow their inclusion focus on postexposure prophylaxis or outpatient treatment of milder disease, limiting the options available to pregnant women with severe COVID-19 to compassionate use of remdesivir, or off-label drug use of hydroxychloroquine or other therapies. These restrictions were put in place despite experience with these drugs in pregnant women. In this Viewpoint, we call attention to the need and urgency to engage pregnant women in COVID-19 treatment trials now in order to develop data-driven recommendations regarding the risks and benefits of therapies in this unique but not uncommon population.", "doi": "10.1093/cid/ciaa444", "pmid": "32296817", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5820683"}, {"db": "pmc", "key": "PMC7184504"}], "notes": [], "created": "2020-12-09T14:47:38.472Z", "modified": "2020-12-09T14:47:38.490Z"}, {"entity": "publication", "iuid": "df6d1ea6bc7443daabbea5f510146e0d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/df6d1ea6bc7443daabbea5f510146e0d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/df6d1ea6bc7443daabbea5f510146e0d"}}, "title": "Generalizability of Coronavirus Disease 2019 (COVID-19) Clinical Prediction Models.", "authors": [{"family": "Hooli", "given": "Shubhada", "initials": "S"}, {"family": "King", "given": "Carina", "initials": "C"}], "type": "letter", "published": "2020-07-28", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "volume": "71", "issue": "15", "pages": "897", "issn-l": "1058-4838"}, "abstract": null, "doi": "10.1093/cid/ciaa417", "pmid": "32271865", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5818447"}, {"db": "pmc", "key": "PMC7184363"}], "notes": [], "created": "2020-11-22T17:15:23.515Z", "modified": "2020-11-22T17:15:23.526Z"}, {"entity": "publication", "iuid": "97538cd2ee6649578f2a9df8210012f6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/97538cd2ee6649578f2a9df8210012f6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/97538cd2ee6649578f2a9df8210012f6"}}, "title": "Computational Studies of SARS-CoV-2 3CLpro: Insights from MD Simulations.", "authors": [{"family": "Grottesi", "given": "Alessandro", "initials": "A"}, {"family": "Be\u0161ker", "given": "Neva", "initials": "N"}, {"family": "Emerson", "given": "Andrew", "initials": "A"}, {"family": "Manelfi", "given": "Candida", "initials": "C"}, {"family": "Beccari", "given": "Andrea R", "initials": "AR"}, {"family": "Frigerio", "given": "Francesco", "initials": "F"}, {"family": "Lindahl", "given": "Erik", "initials": "E"}, {"family": "Cerchia", "given": "Carmen", "initials": "C"}, {"family": "Talarico", "given": "Carmine", "initials": "C"}], "type": "journal article", "published": "2020-07-28", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "21", "issue": "15", "issn-l": null}, "abstract": "Given the enormous social and health impact of the pandemic triggered by severe acute respiratory syndrome 2 (SARS-CoV-2), the scientific community made a huge effort to provide an immediate response to the challenges posed by Coronavirus disease 2019 (COVID-19). One of the most important proteins of the virus is an enzyme, called 3CLpro or main protease, already identified as an important pharmacological target also in SARS and Middle East respiratory syndrome virus (MERS) viruses. This protein triggers the production of a whole series of enzymes necessary for the virus to carry out its replicating and infectious activities. Therefore, it is crucial to gain a deeper understanding of 3CLpro structure and function in order to effectively target this enzyme. All-atoms molecular dynamics (MD) simulations were performed to examine the different conformational behaviors of the monomeric and dimeric form of SARS-CoV-2 3CLpro apo structure, as revealed by microsecond time scale MD simulations. Our results also shed light on the conformational dynamics of the loop regions at the entry of the catalytic site. Studying, at atomic level, the characteristics of the active site and obtaining information on how the protein can interact with its substrates will allow the design of molecules able to block the enzymatic function crucial for the virus.", "doi": "10.3390/ijms21155346", "pmid": "32731361", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Imaging": null}, "xrefs": [{"db": "pii", "key": "ijms21155346"}, {"db": "pmc", "key": "PMC7432786"}], "notes": [], "created": "2020-12-07T16:07:31.972Z", "modified": "2021-02-26T08:45:36.635Z"}, {"entity": "publication", "iuid": "e7c8cb8687554ac194841f84f0afae33", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e7c8cb8687554ac194841f84f0afae33.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e7c8cb8687554ac194841f84f0afae33"}}, "title": "Review of guidelines and recommendations from 17 countries highlights the challenges that clinicians face caring for neonates born to mothers with COVID-19.", "authors": [{"family": "Yeo", "given": "Kee Thai", "initials": "KT"}, {"family": "Oei", "given": "Ju Lee", "initials": "JL"}, {"family": "De Luca", "given": "Daniele", "initials": "D"}, {"family": "Schm\u00f6lzer", "given": "Georg M", "initials": "GM"}, {"family": "Guaran", "given": "Robert", "initials": "R"}, {"family": "Palasanthiran", "given": "Pamela", "initials": "P"}, {"family": "Kumar", "given": "Kishore", "initials": "K"}, {"family": "Buonocore", "given": "Giuseppe", "initials": "G"}, {"family": "Cheong", "given": "Jeanie", "initials": "J"}, {"family": "Owen", "given": "Louise S", "initials": "LS"}, {"family": "Kusuda", "given": "Satoshi", "initials": "S"}, {"family": "James", "given": "Jennifer", "initials": "J"}, {"family": "Lim", "given": "Gina", "initials": "G"}, {"family": "Sharma", "given": "Ankur", "initials": "A"}, {"family": "Uthaya", "given": "Sabita", "initials": "S"}, {"family": "Gale", "given": "Christopher", "initials": "C"}, {"family": "Whittaker", "given": "Elizabeth", "initials": "E"}, {"family": "Battersby", "given": "Cheryl", "initials": "C"}, {"family": "Modi", "given": "Neena", "initials": "N"}, {"family": "Norman", "given": "Mikael", "initials": "M"}, {"family": "Naver", "given": "Lars", "initials": "L"}, {"family": "Giannoni", "given": "Eric", "initials": "E"}, {"family": "Diambomba", "given": "Yenge", "initials": "Y"}, {"family": "Shah", "given": "Prakeshkumar S", "initials": "PS"}, {"family": "Gagliardi", "given": "Luigi", "initials": "L"}, {"family": "Harrison", "given": "Michael", "initials": "M"}, {"family": "Pillay", "given": "Shakti", "initials": "S"}, {"family": "Alburaey", "given": "Abdullah", "initials": "A"}, {"family": "Yuan", "given": "Yuan", "initials": "Y"}, {"family": "Zhang", "given": "Huayan", "initials": "H"}], "type": "journal article", "published": "2020-07-27", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "volume": null, "issue": null, "issn-l": null}, "abstract": "This review examined how applicable national and regional clinical practice guidelines and recommendations for managing neonates born to mothers with COVID-19 mothers were to the evolving pandemic.\n\nA systematic search and review identified 20 guidelines and recommendations that had been published by May 25, 2020. We analysed documents from 17 countries: Australia, Brazil, Canada, China, France, India, Italy, Japan, Saudi Arabia, Singapore, South Africa, South Korea, Spain, Sweden, Switzerland, the UK and the United States.\n\nThe documents were based on expert consensus with limited evidence and were of variable, low methodological rigour. Most did not provide recommendations for delivery methods or managing symptomatic infants. None provided recommendations for post-discharge assimilation of potentially infected infants into the community. The majority encouraged keeping mothers and infants together, subject to infection control measures, but one-third recommended separation. Although breastfeeding or using breastmilk was widely encouraged, two countries specifically prohibited this.\n\nThe guidelines and recommendations for managing infants affected by COVID-19 were of low, variable quality and may be unsustainable. It is important that transmission risks are not increased when new information is incorporated into clinical recommendations. Practice guidelines should emphasise the extent of uncertainty and clearly define gaps in the evidence.", "doi": "10.1111/apa.15495", "pmid": "32716579", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-26T12:17:38.777Z", "modified": "2020-11-30T08:44:14.646Z"}, {"entity": "publication", "iuid": "871f7354d16c4d1ca89d4b422bd909c6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/871f7354d16c4d1ca89d4b422bd909c6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/871f7354d16c4d1ca89d4b422bd909c6"}}, "title": "Efficacy of Corticosteroids in Patients with SARS, MERS and COVID-19: A Systematic Review and Meta-Analysis.", "authors": [{"family": "Lee", "given": "Keum Hwa", "initials": "KH"}, {"family": "Yoon", "given": "Sojung", "initials": "S"}, {"family": "Jeong", "given": "Gwang Hun", "initials": "GH"}, {"family": "Kim", "given": "Jong Yeob", "initials": "JY"}, {"family": "Han", "given": "Young Joo", "initials": "YJ"}, {"family": "Hong", "given": "Sung Hwi", "initials": "SH"}, {"family": "Ryu", "given": "Seohyun", "initials": "S"}, {"family": "Kim", "given": "Jae Seok", "initials": "JS"}, {"family": "Lee", "given": "Jun Young", "initials": "JY"}, {"family": "Yang", "given": "Jae Won", "initials": "JW"}, {"family": "Lee", "given": "Jinhee", "initials": "J"}, {"family": "Solmi", "given": "Marco", "initials": "M"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Jacob", "given": "Louis", "initials": "L"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Smith", "given": "Lee", "initials": "L"}, {"family": "Oh", "given": "Hans", "initials": "H"}, {"family": "Tizaoui", "given": "Kalthoum", "initials": "K"}, {"family": "Cargnin", "given": "Sarah", "initials": "S"}, {"family": "Terrazzino", "given": "Salvatore", "initials": "S"}, {"family": "Ghayda", "given": "Ramy Abou", "initials": "RA"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Shin", "given": "Jae Il", "initials": "JI"}], "type": "journal article", "published": "2020-07-27", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "9", "issue": "8", "issn-l": "2077-0383"}, "abstract": "(1) Background: The use of corticosteroids in critical coronavirus infections, including severe acute respiratory syndrome (SARS), Middle East Respiratory Syndrome (MERS), or Coronavirus disease 2019 (COVID-19), has been controversial. However, a meta-analysis on the efficacy of steroids in treating these coronavirus infections is lacking. (2) Purpose: We assessed a methodological criticism on the quality of previous published meta-analyses and the risk of misleading conclusions with important therapeutic consequences. We also examined the evidence of the efficacy of corticosteroids in reducing mortality in SARS, MERS and COVID-19. (3) Methods: PubMed, MEDLINE, Embase, and Web of Science were used to identify studies published until 25 April 2020, that reported associations between steroid use and mortality in treating SARS/MERS/COVID-19. Two investigators screened and extracted data independently. Searches were restricted to studies on humans, and articles that did not report the exact number of patients in each group or data on mortality were excluded. We calculated odds ratios (ORs) or hazard ratios (HRs) under the fixed- and random-effect model. (4) Results: Eight articles (4051 patients) were eligible for inclusion. Among these selected studies, 3416 patients were diagnosed with SARS, 360 patients with MERS, and 275 with COVID-19; 60.3% patients were administered steroids. The meta-analyses including all studies showed no differences overall in terms of mortality (OR 1.152, 95% CI 0.631-2.101 in the random effects model, p = 0.645). However, this conclusion might be biased, because, in some studies, the patients in the steroid group had more severe symptoms than those in the control group. In contrast, when the meta-analysis was performed restricting only to studies that used appropriate adjustment (e.g., time, disease severity), there was a significant difference between the two groups (HR 0.378, 95% CI 0.221-0.646 in the random effects model, p < 0.0001). Although there was no difference in mortality when steroids were used in severe cases, there was a difference among the group with more underlying diseases (OR 3.133, 95% CI 1.670-5.877, p < 0.001). (5) Conclusions: To our knowledge, this study is the first comprehensive systematic review and meta-analysis providing the most accurate evidence on the effect of steroids in coronavirus infections. If not contraindicated, and in the absence of side effects, the use of steroids should be considered in coronavirus infection including COVID-19.", "doi": "10.3390/jcm9082392", "pmid": "32726951", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jcm9082392"}, {"db": "pmc", "key": "PMC7465945"}], "notes": [], "created": "2020-11-26T12:15:27.760Z", "modified": "2020-11-30T08:44:13.309Z"}, {"entity": "publication", "iuid": "d94b8fd3ab114fbab0ca35902c0364b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d94b8fd3ab114fbab0ca35902c0364b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d94b8fd3ab114fbab0ca35902c0364b3"}}, "title": "Compliance to Recommendations and Mental Health Consequences among Elderly in Sweden during the Initial Phase of the COVID-19 Pandemic-A Cross Sectional Online Survey.", "authors": [{"family": "Gustavsson", "given": "Johanna", "initials": "J"}, {"family": "Beckman", "given": "Linda", "initials": "L"}], "type": "journal article", "published": "2020-07-26", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "15", "pages": "5380"}, "abstract": "Background (1): In the wake of COVID-19, elderly people have been labelled a risk group. As the pandemic is a new crisis in Sweden, we have no knowledge on how this group perceives the information and recommendations being provided. Complying with these recommendations entails physical distancing and, for some, isolation at home. Methods (2): From 16 April to 15 May 2020, we conducted an online survey targeting people aged 70 and older in Sweden (n = 1854). Results (3): A vast majority of the participants find the information and recommendations clear and reliable. Half of the participants report staying at home all the time, and up to half report decreased mental health in terms of, e.g., feeling depressed, having sleeping problems and that isolation makes them feel bad. However, elderly people are not a homogenous group, and there are gender and demographic differences. (4) Conclusion: At this point, we do not know the full extent of the ongoing pandemic, either in terms of duration or in terms of losses. The Swedish model for action on COVID-19 has not included a lock down. However, elderly people seem to comply with recommendations and practice social distancing to a high degree. This might lead to decreased mental health and long-term effects.", "doi": "10.3390/ijerph17155380", "pmid": "32722624", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7432611"}, {"db": "pii", "key": "ijerph17155380"}], "notes": [], "created": "2020-12-07T16:08:58.764Z", "modified": "2023-06-19T14:51:29.461Z"}, {"entity": "publication", "iuid": "237450facd3243e6a1f106b316d527f3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/237450facd3243e6a1f106b316d527f3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/237450facd3243e6a1f106b316d527f3"}}, "title": "Current Status of COVID-19 Therapies and Drug Repositioning Applications.", "authors": [{"family": "Altay", "given": "Ozlem", "initials": "O"}, {"family": "Mohammadi", "given": "Elyas", "initials": "E"}, {"family": "Lam", "given": "Simon", "initials": "S", "orcid": "0000-0002-4476-0971", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89c92490f9c747da8af1c28fc155ac8a.json"}}, {"family": "Turkez", "given": "Hasan", "initials": "H"}, {"family": "Boren", "given": "Jan", "initials": "J"}, {"family": "Nielsen", "given": "Jens", "initials": "J", "orcid": "0000-0002-9955-6003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f4b76d85efe148889e8a33aa78a75c87.json"}}, {"family": "Uhlen", "given": "Mathias", "initials": "M"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb9f5331ce524497923b4d7044bed6a8.json"}}], "type": "journal article", "published": "2020-07-24", "journal": {"title": "iScience", "issn": "2589-0042", "issn-l": "2589-0042", "volume": "23", "issue": "7", "pages": "101303"}, "abstract": "The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19. Drug repositioning is an attractive approach that can facilitate the drug discovery process by repurposing existing pharmaceuticals to treat illnesses other than their primary indications. Here, we review current information concerning the global health issue of COVID-19 including promising approved drugs and ongoing clinical trials for prospective treatment options. In addition, we describe computational approaches to be used in drug repurposing and highlight examples of in silico studies of drug development efforts against SARS-CoV-2.", "doi": "10.1016/j.isci.2020.101303", "pmid": "32622261", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(20)30490-9"}, {"db": "pmc", "key": "PMC7305759"}], "notes": [], "created": "2020-11-04T13:11:37.791Z", "modified": "2021-06-22T13:25:22.943Z"}, {"entity": "publication", "iuid": "7e6dbde8bcd14d81a72d07014d95c74e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e6dbde8bcd14d81a72d07014d95c74e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e6dbde8bcd14d81a72d07014d95c74e"}}, "title": "Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection.", "authors": [{"family": "Messner", "given": "Christoph B", "initials": "CB"}, {"family": "Demichev", "given": "Vadim", "initials": "V"}, {"family": "Wendisch", "given": "Daniel", "initials": "D"}, {"family": "Michalick", "given": "Laura", "initials": "L"}, {"family": "White", "given": "Matthew", "initials": "M"}, {"family": "Freiwald", "given": "Anja", "initials": "A"}, {"family": "Textoris-Taube", "given": "Kathrin", "initials": "K"}, {"family": "Vernardis", "given": "Spyros I", "initials": "SI"}, {"family": "Egger", "given": "Anna-Sophia", "initials": "A"}, {"family": "Kreidl", "given": "Marco", "initials": "M"}, {"family": "Ludwig", "given": "Daniela", "initials": "D"}, {"family": "Kilian", "given": "Christiane", "initials": "C"}, {"family": "Agostini", "given": "Federica", "initials": "F"}, {"family": "Zelezniak", "given": "Aleksej", "initials": "A"}, {"family": "Thibeault", "given": "Charlotte", "initials": "C"}, {"family": "Pfeiffer", "given": "Moritz", "initials": "M"}, {"family": "Hippenstiel", "given": "Stefan", "initials": "S"}, {"family": "Hocke", "given": "Andreas", "initials": "A"}, {"family": "von Kalle", "given": "Christof", "initials": "C"}, {"family": "Campbell", "given": "Archie", "initials": "A"}, {"family": "Hayward", "given": "Caroline", "initials": "C"}, {"family": "Porteous", "given": "David J", "initials": "DJ"}, {"family": "Marioni", "given": "Riccardo E", "initials": "RE"}, {"family": "Langenberg", "given": "Claudia", "initials": "C"}, {"family": "Lilley", "given": "Kathryn S", "initials": "KS"}, {"family": "Kuebler", "given": "Wolfgang M", "initials": "WM"}, {"family": "M\u00fclleder", "given": "Michael", "initials": "M"}, {"family": "Drosten", "given": "Christian", "initials": "C"}, {"family": "Suttorp", "given": "Norbert", "initials": "N"}, {"family": "Witzenrath", "given": "Martin", "initials": "M"}, {"family": "Kurth", "given": "Florian", "initials": "F"}, {"family": "Sander", "given": "Leif Erik", "initials": "LE"}, {"family": "Ralser", "given": "Markus", "initials": "M"}], "type": "journal article", "published": "2020-07-22", "journal": {"title": "Cell Syst", "issn": "2405-4720", "issn-l": null, "volume": "11", "issue": "1", "pages": "11-24.e4"}, "abstract": "The COVID-19 pandemic is an unprecedented global challenge, and point-of-care diagnostic classifiers are urgently required. Here, we present a platform for ultra-high-throughput serum and plasma proteomics that builds on ISO13485 standardization to facilitate simple implementation in regulated clinical laboratories. Our low-cost workflow handles up to 180 samples per day, enables high precision quantification, and reduces batch effects for large-scale and longitudinal studies. We use our platform on samples collected from a cohort of early hospitalized cases of the SARS-CoV-2 pandemic and identify 27 potential biomarkers that are differentially expressed depending on the WHO severity grade of COVID-19. They include complement factors, the coagulation system, inflammation modulators, and pro-inflammatory factors upstream and downstream of interleukin 6. All protocols and software for implementing our approach are freely available. In total, this work supports the development of routine proteomic assays to aid clinical decision making and generate hypotheses about potential COVID-19 therapeutic targets.", "doi": "10.1016/j.cels.2020.05.012", "pmid": "32619549", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Proteins": null, "Category: Serology": null}, "xrefs": [{"db": "pii", "key": "S2405-4712(20)30197-6"}, {"db": "pmc", "key": "PMC7264033"}], "notes": [], "created": "2020-12-08T15:06:05.260Z", "modified": "2022-11-10T07:33:00.728Z"}, {"entity": "publication", "iuid": "ff6f8d98da824a7d8c7ab483aeade546", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff6f8d98da824a7d8c7ab483aeade546.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff6f8d98da824a7d8c7ab483aeade546"}}, "title": "Substance Use Disorders and COVID-19: Multi-Faceted Problems Which Require Multi-Pronged Solutions.", "authors": [{"family": "Jemberie", "given": "Wossenseged Birhane", "initials": "WB"}, {"family": "Stewart Williams", "given": "Jennifer", "initials": "J"}, {"family": "Eriksson", "given": "Malin", "initials": "M"}, {"family": "Gr\u00f6nlund", "given": "Ann-Sofie", "initials": "AS"}, {"family": "Ng", "given": "Nawi", "initials": "N"}, {"family": "Blom Nilsson", "given": "Marcus", "initials": "M"}, {"family": "Padyab", "given": "Mojgan", "initials": "M"}, {"family": "Priest", "given": "Kelsey Caroline", "initials": "KC"}, {"family": "Sandlund", "given": "Mikael", "initials": "M"}, {"family": "Snellman", "given": "Fredrik", "initials": "F"}, {"family": "McCarty", "given": "Dennis", "initials": "D"}, {"family": "Lundgren", "given": "Lena M", "initials": "LM"}], "type": "journal article", "published": "2020-07-21", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "11", "issue": null, "pages": "714", "issn-l": "1664-0640"}, "abstract": "COVID-19 shocked health and economic systems leaving millions of people without employment and safety nets. The pandemic disproportionately affects people with substance use disorders (SUDs) due to the collision between SUDs and COVID-19. Comorbidities and risk environments for SUDs are likely risk factors for COVID-19. The pandemic, in turn, diminishes resources that people with SUD need for their recovery and well-being. This article presents an interdisciplinary and international perspective on how COVID-19 and the related systemic shock impact on individuals with SUDs directly and indirectly. We highlight a need to understand SUDs as biopsychosocial disorders and use evidence-based policies to destigmatize SUDs. We recommend a suite of multi-sectorial actions and strategies to strengthen, modernize and complement addiction care systems which will become resilient and responsive to future systemic shocks similar to the COVID-19 pandemic.", "doi": "10.3389/fpsyt.2020.00714", "pmid": "32848907", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7396653"}], "notes": [], "created": "2020-12-07T10:23:23.099Z", "modified": "2020-12-07T10:23:40.294Z"}, {"entity": "publication", "iuid": "10054aad3a5c4b87aef56f880a53e7d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/10054aad3a5c4b87aef56f880a53e7d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/10054aad3a5c4b87aef56f880a53e7d5"}}, "title": "Non-Bacterial Thrombotic Endocarditis: A Presentation of COVID-19.", "authors": [{"family": "Balata", "given": "Dilan", "initials": "D"}, {"family": "Mellerg\u00e5rd", "given": "Johan", "initials": "J"}, {"family": "Ekqvist", "given": "David", "initials": "D"}, {"family": "Baranowski", "given": "Jacek", "initials": "J"}, {"family": "Garcia", "given": "Isidro Albert", "initials": "IA"}, {"family": "Volosyraki", "given": "Marina", "initials": "M"}, {"family": "Broqvist", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2020-07-21", "journal": {"title": "Eur J Case Rep Intern Med", "issn": "2284-2594", "volume": "7", "issue": "8", "pages": "001811", "issn-l": null}, "abstract": "The SARS-CoV-2 virus is a newly emergent pathogen first identified in Wuhan, China, and responsible for the COVID-19 global pandemic. In this case report we describe a manifestation of non-bacterial thrombotic endocarditis with continuous peripheral embolization in a COVID-19-positive patient. The patient responded well to high-dose LMWH treatment with cessation of the embolic process.\n\nRaising awareness of possible complications of COVID-19.To highlight the importance of the careful consideration of and dosage of anticoagulation in non-bacterial thrombotic endocarditis.", "doi": "10.12890/2020_001811", "pmid": "32789144", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "1811-1-15256-1-10-20200720"}, {"db": "pmc", "key": "PMC7417053"}], "notes": [], "created": "2020-12-07T13:26:39.296Z", "modified": "2020-12-07T13:26:52.483Z"}, {"entity": "publication", "iuid": "f7fa3b5f385f4911885bc7374541634f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7fa3b5f385f4911885bc7374541634f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7fa3b5f385f4911885bc7374541634f"}}, "title": "Multidisciplinary Tracheostomy Quality Improvement in the COVID-19 Pandemic: Building a Global Learning Community.", "authors": [{"family": "Swords", "given": "Chloe", "initials": "C"}, {"family": "Bergman", "given": "Lina", "initials": "L"}, {"family": "Wilson-Jeffers", "given": "Rachel", "initials": "R"}, {"family": "Randall", "given": "Diane", "initials": "D"}, {"family": "Morris", "given": "Linda L", "initials": "LL"}, {"family": "Brenner", "given": "Michael J", "initials": "MJ"}, {"family": "Arora", "given": "Asit", "initials": "A"}], "type": "journal article", "published": "2020-07-17", "journal": {"title": "Ann Otol Rhinol Laryngol", "issn": "1943-572X", "volume": null, "issue": null, "pages": "3489420941542", "issn-l": null}, "abstract": "To report experience with a global multidisciplinary tracheostomy e-learning initiative.\n\nAn international multidisciplinary panel of experts convened to build a virtual learning community for tracheostomy care, comprising a web-based platform, five distance learning (interactive webinar) sessions, and professional discourse over 12 months. Structured pre- and post-webinar surveys were disseminated to global participants including otolaryngologists, intensivists, nurses, allied health professionals, and patients/caregivers. Data were collected on audio-visual fidelity, demographics, and pre- and post-tutorial assessments regarding experience and skill acquisition. Participants reported confidence levels for NICU, pediatric, adult, and family care, as well as technical skills, communication, learning, assessment, and subdomains.\n\nParticipants from 197 institutions in 22 countries engaged in the virtual education platform, including otolaryngologists, speech pathologists, respiratory therapists, specialist nurses, patients, and caregivers. Significant improvements were reported in communication ( P < .0001), clinical assessments (P < .0001), and clinical governance (P < .0001), with positive impact on pediatric decannulation (P = .0008), adult decannulation (P = .04), and quality improvement (P < .0001). Respondents reported enhanced readiness to integrate knowledge into practice. Barriers included time zones, internet bandwidth, and perceived difficulty of direct clinical translation of highly technical skills. Participants rated the implementation highly in terms of length, ability for discussion, satisfaction, applicability to professional practice, and expertise of discussants (median scores: 4, 4, 4, 4 and 5 out of 5).\n\nVirtual learning has dominated the education landscape during COVID-19 pandemic, but few data are available on its effectiveness. This study demonstrated feasibility of virtual learning for disseminating best practices in tracheostomy, engaging a diverse, multidisciplinary audience. Learning of complex technical skills proved a hurdle, however, suggesting need for hands-on experience for technical mastery. While interactive videoconferencing via webinar affords an engaging and scalable strategy for sharing knowledge, further investigation is needed on clinical outcomes to define effective strategies for experiential online learning and virtual in-service simulations.", "doi": "10.1177/0003489420941542", "pmid": "32680435", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7369399"}], "notes": [], "created": "2020-12-07T16:32:06.801Z", "modified": "2020-12-07T16:33:54.718Z"}, {"entity": "publication", "iuid": "1d34255c1b8d4bde8b603828a8fc2bc8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d34255c1b8d4bde8b603828a8fc2bc8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d34255c1b8d4bde8b603828a8fc2bc8"}}, "title": "Role of Environmental Temperature on the Attack rate and Case fatality rate of Coronavirus Disease 2019 (COVID-19) Pandemic.", "authors": [{"family": "Hassan", "given": "Mohammad M", "initials": "MM"}, {"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME"}, {"family": "Khan", "given": "Shahneaz A", "initials": "SA"}, {"family": "Islam", "given": "Ariful", "initials": "A"}, {"family": "Nayem", "given": "Md Raihan K", "initials": "MRK"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}], "type": "journal article", "published": "2020-07-16", "journal": {"title": "Infect Ecol Epidemiol", "issn": "2000-8686", "volume": "10", "issue": "1", "pages": "1792620", "issn-l": "2000-8686"}, "abstract": "SARS-CoV-2 is a zoonotic Betacoronavirus causing the devastating COVID-19 pandemic. More than twelve million COVID-19 cases and 500 thousand fatalities have been reported in 216 countries. Although SARS-CoV-2 originated in China, comparatively fewer people have been affected in other Asian countries than in Europe and the USA. This study examined the hypothesis that lower temperature may increase the spread of SARS-CoV-2 by comparing attack rate and case fatality rate (until 21 March 2020) to mean temperature in January-February 2020. The attack rate was highest in Luxembourg followed by Italy and Switzerland. There was a significant (p = 0.02) correlation between decreased attack rate and increased environmental temperature. The case fatality rate was highest in Italy followed by Iran and Spain. There was no significant correlation between the case fatality rate and temperature. This study indicates that lower temperature may increase SARS-CoV-2 transmission (measured as an increased attack rate), but there is no evidence that temperature affects the severity of the disease (measured as case fatality rate). However, there are clearly other factors that affect the transmission of SARS-CoV-2, and many of these may be sensitive to interventions, e.g. through increased public awareness and public health response.", "doi": "10.1080/20008686.2020.1792620", "pmid": "32944163", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "1792620"}, {"db": "pmc", "key": "PMC7480504"}], "notes": [], "created": "2020-11-18T17:34:57.249Z", "modified": "2021-02-26T08:46:12.968Z"}, {"entity": "publication", "iuid": "c23bcab33a00461ca27d92a08ead96cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c23bcab33a00461ca27d92a08ead96cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c23bcab33a00461ca27d92a08ead96cf"}}, "title": "Repurposing CD8 + T cell immunity against SARS-CoV-2 for cancer immunotherapy: a positive aspect of the COVID-19 pandemic?", "authors": [{"family": "Gujar", "given": "Shashi", "initials": "S"}, {"family": "Pol", "given": "Jonathan G", "initials": "JG"}, {"family": "Kim", "given": "Youra", "initials": "Y"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}], "type": "journal article", "published": "2020-07-16", "journal": {"title": "Oncoimmunology", "issn": "2162-4011", "volume": "9", "issue": "1", "pages": "1794424", "issn-l": null}, "abstract": "The COVID-19 pandemic has afflicted most countries on the planet. As a result, immunity against SARS-CoV-2, induced via natural infections or imminent vaccinations, is expected to develop in a large fraction of the global population. Here, we propose to exploit SARS-CoV-2-specific CD8 + T cells for cancer immunotherapy strategies.", "doi": "10.1080/2162402X.2020.1794424", "pmid": "32923158", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "1794424"}, {"db": "pmc", "key": "PMC7458627"}], "notes": [], "created": "2020-11-26T12:31:06.390Z", "modified": "2020-11-26T12:31:06.401Z"}, {"entity": "publication", "iuid": "19037d975bdc46d69a046a10002818f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19037d975bdc46d69a046a10002818f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19037d975bdc46d69a046a10002818f0"}}, "title": "Effect of statins on SARS-CoV-2 infection", "authors": [{"family": "Moeller", "given": "Rebecca", "initials": "R"}, {"family": "Zapatero-Belinch\u00f3n", "given": "Francisco J", "initials": "FJ"}, {"family": "Lasswitz", "given": "Lisa", "initials": "L"}, {"family": "Kirui", "given": "Jared", "initials": "J"}, {"family": "Brogden", "given": "Graham", "initials": "G"}, {"family": "Gunesch", "given": "Antonia P", "initials": "AP"}, {"family": "Pietschmann", "given": "Thomas", "initials": "T"}, {"family": "Wichmann", "given": "Dominic", "initials": "D"}, {"family": "Kluge", "given": "Stefan", "initials": "S"}, {"family": "Gerold", "given": "Gisa", "initials": "G", "orcid": "0000-0002-1326-5038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39af3df98cf14f96baa155798617841b.json"}}], "type": "posted-content", "published": "2020-07-14", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.07.13.20152272", "pmid": null, "labels": {"Funder: KAW/SciLifeLab": null, "Type: Preprint": null, "Research Area: Host cell systems biology and targets": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-15T16:41:57.170Z", "modified": "2022-11-22T05:52:24.479Z"}, {"entity": "publication", "iuid": "61c4d6c1a504486f9ab36320ec38bdd3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61c4d6c1a504486f9ab36320ec38bdd3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61c4d6c1a504486f9ab36320ec38bdd3"}}, "title": "Discriminative Bayesian Serology: Counting Without Cutoffs", "authors": [{"family": "Christian", "given": "Murray", "initials": "M"}, {"family": "Murrell", "given": "Ben", "initials": "B", "orcid": "0000-0002-0393-4445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60dac9ecf84d4eb3b90fb4ee1298bc52.json"}}], "type": "posted-content", "published": "2020-07-14", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.07.14.202150", "pmid": null, "labels": {"Type: Preprint": null, "Funder: H2020": null, "Category: Other": null, "Category: Serology": null}, "xrefs": [], "notes": [], "created": "2021-01-08T09:00:29.416Z", "modified": "2022-11-10T07:33:32.183Z"}, {"entity": "publication", "iuid": "e541e41eb72f48c6989a921a797b6bd8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e541e41eb72f48c6989a921a797b6bd8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e541e41eb72f48c6989a921a797b6bd8"}}, "title": "Covid-19: an opportunity to reduce unnecessary healthcare.", "authors": [{"family": "Moynihan", "given": "Ray", "initials": "R"}, {"family": "Johansson", "given": "Minna", "initials": "M"}, {"family": "Maybee", "given": "Alies", "initials": "A"}, {"family": "Lang", "given": "Eddy", "initials": "E"}, {"family": "L\u00e9gar\u00e9", "given": "France", "initials": "F"}], "type": "editorial", "published": "2020-07-14", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "370", "issue": null, "pages": "m2752", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m2752", "pmid": "32665257", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-08T10:41:40.545Z", "modified": "2020-12-08T10:41:40.554Z"}, {"entity": "publication", "iuid": "14a924a1edb949dc91ae4e6f9e35714c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/14a924a1edb949dc91ae4e6f9e35714c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/14a924a1edb949dc91ae4e6f9e35714c"}}, "title": "An immunotherapeutic method for COVID-19 patients: a soluble ACE2-Anti-CD16 VHH to block SARS-CoV-2 Spike protein.", "authors": [{"family": "Sheikhi", "given": "Abdolkarim", "initials": "A"}, {"family": "Hojjat-Farsangi", "given": "Mohammad", "initials": "M"}], "type": "journal article", "published": "2020-07-14", "journal": {"title": "Hum Vaccin Immunother", "issn": "2164-554X", "issn-l": null, "volume": null, "issue": null, "pages": "1-6"}, "abstract": "The third outbreak of coronavirus (CoV) infection (after SARS-CoV and MERS-CoV) caused by a novel CoV (SARS-CoV-2) of the genus Beta-coronavirus has become a global pandemic. CoVs are enveloped viruses whose proteins include spike (S), membrane (M), and envelope (E) which are embedded in the viral envelope. The glycosylated S protein, which forms homo-trimeric spikes on the surface of the viral particle, mediates viral entry into host cells. SARS-CoV-2, like SARS-CoV, uses the Angiotensin-Converting Enzyme 2 (ACE2) cell surface protein for cellular entry. An attractive anti-viral approach is targeting virus entry into cells, for which three strategies are suggested: 1) direct targeting of the viral glycoprotein; 2) targeting the viral receptor on the cell surface; and 3) using soluble (s) ACE2 that binds to S protein thereby neutralizing the virus. In this article, the advantages and disadvantages of these strategies are explained. Moreover, we propose that fusion of the sACE2 to anti-CD16 to produce a bi-speci\ufb01c molecule could be a promising anti-viral strategy.", "doi": "10.1080/21645515.2020.1787066", "pmid": "32663051", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-08T10:42:25.787Z", "modified": "2020-12-08T10:42:53.471Z"}, {"entity": "publication", "iuid": "097a76b78d194ee4b04ef819bfdb543c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/097a76b78d194ee4b04ef819bfdb543c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/097a76b78d194ee4b04ef819bfdb543c"}}, "title": "Misinformation and de-contextualization: international media reporting on Sweden and COVID-19.", "authors": [{"family": "Irwin", "given": "Rachel Elisabeth", "initials": "RE"}], "type": "journal article", "published": "2020-07-13", "journal": {"title": "Global Health", "issn": "1744-8603", "volume": "16", "issue": "1", "pages": "62", "issn-l": "1744-8603"}, "abstract": "In the first month of the 2020 COVID-19 pandemic, Sweden took the same strategy as most other countries, working to \"flatten the curve,\" by slowing transmission so that the healthcare system could cope with the disease. However, unlike most other countries, much of Sweden's implementation focused on voluntary and stepwise action, rather than legislation and compulsory measures, leading to considerable attention in the international media.Six main narratives emerged in the international media reporting on Sweden during the first month of the COVID-19 pandemic: (1) Life is normal in Sweden, (2) Sweden has a herd immunity strategy, (3) Sweden is not following expert advice, (4) Sweden is not following WHO recommendations (5) the Swedish approach is failing and (6) Swedes trust the government. While these narratives are partially grounded in reality, in some media outlets, the language and examples used to frame the story distorted the accuracy of the reporting.This debate examines the ways in which international media both constructs and represents a pandemic, and the implications for how researchers engage with news and social media. Cross-country comparison and the sharing of best practice are reliant on accurate information. The Swedish example underlines the importance of fact checking and source critique and the need for precision when presenting data and statistics. It also highlights limitations of using culture as an explanation for behavior, and the pitfalls of evaluating policy during a pandemic.", "doi": "10.1186/s12992-020-00588-x", "pmid": "32660503", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12992-020-00588-x"}, {"db": "pmc", "key": "PMC7356107"}], "notes": [], "created": "2020-12-08T10:44:40.041Z", "modified": "2020-12-08T10:44:40.049Z"}, {"entity": "publication", "iuid": "01e9b6b57731417a9927d1ad9f5d4027", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01e9b6b57731417a9927d1ad9f5d4027.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01e9b6b57731417a9927d1ad9f5d4027"}}, "title": "Effects of COVID-19 on Plastic Surgery Practices and Medi-Spas in Different Countries.", "authors": [{"family": "Montemurro", "given": "Paolo", "initials": "P"}, {"family": "Hed\u00e9n", "given": "Per", "initials": "P"}, {"family": "Adams", "given": "William P", "initials": "WP"}, {"family": "de Vita", "given": "Roy", "initials": "R"}, {"family": "Pellegatta", "given": "Tommaso", "initials": "T"}], "type": "letter", "published": "2020-07-13", "journal": {"title": "Aesthet Surg J", "issn": "1527-330X", "volume": "40", "issue": "8", "pages": "N453-N456", "issn-l": null}, "abstract": null, "doi": "10.1093/asj/sjaa104", "pmid": "32495819", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5851306"}, {"db": "pmc", "key": "PMC7314219"}], "notes": [], "created": "2020-12-09T10:48:40.042Z", "modified": "2020-12-09T10:48:40.065Z"}, {"entity": "publication", "iuid": "a1107310294e40e8886c613539a3151b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a1107310294e40e8886c613539a3151b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a1107310294e40e8886c613539a3151b"}}, "title": "The link between vitamin D and COVID-19: distinguishing facts from fiction.", "authors": [{"family": "Bergman", "given": "P", "initials": "P"}], "type": "editorial", "published": "2020-07-11", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1111/joim.13158", "pmid": "32652766", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7405052"}], "notes": [], "created": "2020-12-08T14:17:01.925Z", "modified": "2020-12-08T14:17:01.938Z"}, {"entity": "publication", "iuid": "0ffc406108044dabb325c6ff9858e0ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ffc406108044dabb325c6ff9858e0ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ffc406108044dabb325c6ff9858e0ae"}}, "title": "Psychometric Testing of Three COVID-19-Related Scales Among People with Mental Illness.", "authors": [{"family": "Chang", "given": "Kun-Chia", "initials": "KC"}, {"family": "Hou", "given": "Wen-Li", "initials": "WL"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}], "type": "journal article", "published": "2020-07-11", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "volume": null, "issue": null, "pages": "1-13", "issn-l": null}, "abstract": "Fear of novel coronavirus 2019 (COVID-19) may result in psychological health problems among different populations. Moreover, believing COVID-19 information and preventive COVID-19 infection behaviors are relevant constructs associated with fear of COVID-19. Therefore, the present study validated three instruments assessing fear, beliefs, and preventive behaviors related to COVID-19 among individuals with mental illness. Moreover, relationships between the three constructs were examined. Individuals with mental illness ( N = 400; 178 females; mean age = 46.91 years) completed the Fear of COVID-19 Scale (FCV-19S), Believing COVID-19 Information Scale (BCIS), Preventive COVID-19 Infection Behaviors Scale (PCIBS), and Depression Anxiety Stress Scale-21 (DASS-21). The FCV-19S, BCIS, and PCIBS demonstrated a single-factor structure with satisfactory fit indices. Moreover, believing COVID-19 information positively and significantly associated with fear of COVID-19, and fear of COVID-19 negatively and significantly associated with preventive behaviors and positively and significantly associated with psychological distress. The FCV-19S, BCIS, and PCIBS may assist healthcare providers in assessing COVID-19-related information among individuals with mental illness. Consequently, relevant programs may be designed to help individuals with mental illness going through the period of crisis.", "doi": "10.1007/s11469-020-00361-6", "pmid": "32837442", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "361"}, {"db": "pmc", "key": "PMC7354353"}], "notes": [], "created": "2020-12-07T10:34:46.665Z", "modified": "2021-02-26T08:45:47.848Z"}, {"entity": "publication", "iuid": "4d025e959931413b8de13ebe37146358", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4d025e959931413b8de13ebe37146358.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4d025e959931413b8de13ebe37146358"}}, "title": "Economic, Mental Health, HIV Prevention and HIV Treatment Impacts of COVID-19 and the COVID-19 Response on a Global Sample of Cisgender Gay Men and Other Men Who Have Sex with Men.", "authors": [{"family": "Santos", "given": "Glenn-Milo", "initials": "G"}, {"family": "Ackerman", "given": "Benjamin", "initials": "B"}, {"family": "Rao", "given": "Amrita", "initials": "A"}, {"family": "Wallach", "given": "Sara", "initials": "S"}, {"family": "Ayala", "given": "George", "initials": "G"}, {"family": "Lamontage", "given": "Erik", "initials": "E"}, {"family": "Garner", "given": "Alex", "initials": "A"}, {"family": "Holloway", "given": "Ian W", "initials": "IW"}, {"family": "Arreola", "given": "Sonya", "initials": "S"}, {"family": "Silenzio", "given": "Vince", "initials": "V"}, {"family": "Str\u00f6mdahl", "given": "Susanne", "initials": "S"}, {"family": "Yu", "given": "Louis", "initials": "L"}, {"family": "Strong", "given": "Carol", "initials": "C"}, {"family": "Adamson", "given": "Tyler", "initials": "T"}, {"family": "Yakusik", "given": "Anna", "initials": "A"}, {"family": "Doan", "given": "Tran Thu", "initials": "TT"}, {"family": "Huang", "given": "Poyao", "initials": "P"}, {"family": "Cerasuolo", "given": "Damiano", "initials": "D"}, {"family": "Bishop", "given": "Amie", "initials": "A"}, {"family": "Noori", "given": "Teymur", "initials": "T"}, {"family": "Pharris", "given": "Anastasia", "initials": "A"}, {"family": "Aung", "given": "Max", "initials": "M"}, {"family": "Dara", "given": "Masoud", "initials": "M"}, {"family": "Chung", "given": "Ssu Yu", "initials": "SY"}, {"family": "Hanley", "given": "Marguerite", "initials": "M"}, {"family": "Baral", "given": "Stefan", "initials": "S"}, {"family": "Beyrer", "given": "Chris", "initials": "C"}, {"family": "Howell", "given": "Sean", "initials": "S"}], "type": "journal article", "published": "2020-07-11", "journal": {"title": "AIDS Behav", "issn": "1573-3254", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "There is an urgent need to measure the impacts of COVID-19 among gay men and other men who have sex with men (MSM). We conducted a cross-sectional survey with a global sample of gay men and other MSM (n = 2732) from April 16, 2020 to May 4, 2020, through a social networking app. We characterized the economic, mental health, HIV prevention and HIV treatment impacts of COVID-19 and the COVID-19 response, and examined whether sub-groups of our study population are disproportionately impacted by COVID-19. Many gay men and other MSM not only reported economic and mental health consequences, but also interruptions to HIV prevention and testing, and HIV care and treatment services. These consequences were significantly greater among people living with HIV, racial/ethnic minorities, immigrants, sex workers, and socio-economically disadvantaged groups. These findings highlight the urgent need to mitigate the negative impacts of COVID-19 among gay men and other MSM.", "doi": "10.1007/s10461-020-02969-0", "pmid": "32654021", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10461-020-02969-0"}, {"db": "pmc", "key": "PMC7352092"}], "notes": [], "created": "2020-12-08T14:16:22.309Z", "modified": "2022-11-10T07:36:53.488Z"}, {"entity": "publication", "iuid": "b47287449a85462a81f301754bf0fea5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b47287449a85462a81f301754bf0fea5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b47287449a85462a81f301754bf0fea5"}}, "title": "Development and Validation of a Nomogram for Assessing Survival in Patients with COVID-19 Pneumonia.", "authors": [{"family": "Dong", "given": "Yi-Min", "initials": "YM"}, {"family": "Sun", "given": "Jia", "initials": "J"}, {"family": "Li", "given": "Yi-Xin", "initials": "YX"}, {"family": "Chen", "given": "Qian", "initials": "Q"}, {"family": "Liu", "given": "Qing-Quan", "initials": "QQ"}, {"family": "Sun", "given": "Zhou", "initials": "Z"}, {"family": "Pang", "given": "Ran", "initials": "R"}, {"family": "Chen", "given": "Fei", "initials": "F"}, {"family": "Xu", "given": "Bing-Yang", "initials": "BY"}, {"family": "Manyande", "given": "Anne", "initials": "A"}, {"family": "Clark", "given": "Taane G", "initials": "TG"}, {"family": "Li", "given": "Jin-Ping", "initials": "JP"}, {"family": "Orhan", "given": "Ilkay Erdogan", "initials": "IE"}, {"family": "Tian", "given": "Yu-Ke", "initials": "YK"}, {"family": "Wang", "given": "Tao", "initials": "T"}, {"family": "Wu", "given": "Wei", "initials": "W"}, {"family": "Ye", "given": "Da-Wei", "initials": "DW"}], "type": "journal article", "published": "2020-07-10", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "volume": null, "issue": null, "issn-l": "1058-4838"}, "abstract": "The outbreak of coronavirus disease (COVID-19) in 2019 has spread worldwide and continues to cause great threat to peoples' health as well as put pressure on the accessibility of medical systems. Early prediction of survival of hospitalized patients will help the clinical management of COVID-19, but such a prediction model which is reliable and valid is still lacking.\n\nWe retrospectively enrolled 628 confirmed cases of COVID-19 using positive RT-PCR tests for SARS-CoV-2 in Tongji Hospital in Wuhan, China. These patients were randomly grouped into a training cohort (60%) and a validation cohort (40%). In the training cohort, least absolute shrinkage and selection operator (LASSO) regression analysis and multivariate Cox regression analysis were utilized to identify prognostic factors for in-hospital survival of patients with COVID-19. A nomogram based on the three variables was built for clinical use. Areas under the ROC curves (AUC), concordance index (C-index) and calibration curve were used to evaluate the efficiency of the nomogram in both the training and validation cohorts.\n\nHypertension, higher neutrophil-to-lymphocyte ratio and increased NT-proBNP value were found to be significantly associated with poorer prognosis in hospitalized patients with COVID-19. The three predictors were further used to build a prediction nomogram. The C-index of the nomogram in the training and validation cohorts was 0.901 and 0.892, respectively. The AUC in the training cohort was 0.922 for 14- day and 0.919 for 21-day probability of in-hospital survival, while in the validation cohort was 0.922 and 0.881, respectively. Moreover, the calibration curve for 14- day and 21-day survival also showed high coherence between the predicted and actual probability of survival.\n\nWe managed to build a predictive model and constructed a nomogram for predicting in-hospital survival of patients with COVID-19. This model represents good performance and might be utilized clinically in the management of COVID-19.", "doi": "10.1093/cid/ciaa963", "pmid": "32649738", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "5869870"}, {"db": "pmc", "key": "PMC7454485"}], "notes": [], "created": "2020-11-19T14:39:34.744Z", "modified": "2021-02-26T08:46:13.460Z"}, {"entity": "publication", "iuid": "4038c04031e8472e973982d27d5b596c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4038c04031e8472e973982d27d5b596c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4038c04031e8472e973982d27d5b596c"}}, "title": "Trauma-informed responses in addressing public mental health consequences of the COVID-19 pandemic: position paper of the European Society for Traumatic Stress Studies (ESTSS).", "authors": [{"family": "Javakhishvili", "given": "Jana Darejan", "initials": "JD"}, {"family": "Ardino", "given": "Vittoria", "initials": "V"}, {"family": "Bragesj\u00f6", "given": "Maria", "initials": "M"}, {"family": "Kazlauskas", "given": "Evaldas", "initials": "E"}, {"family": "Olff", "given": "Miranda", "initials": "M"}, {"family": "Sch\u00e4fer", "given": "Ingo", "initials": "I"}], "type": "journal article", "published": "2020-07-09", "journal": {"title": "Eur J Psychotraumatol", "issn": "2000-8066", "volume": "11", "issue": "1", "pages": "1780782", "issn-l": null}, "abstract": "The COVID-19 pandemic has changed life in Europe and globally. The pandemic affects both individuals and the broader society across many domains, including physical and psychological health, the economy and general welfare. The measures taken to counteract the pandemic have significantly altered daily life and, along with the threat of contracting the coronavirus and uncertainties surrounding future developments, created a complex system of stressors with a negative impact on public mental health. This paper aims to outline the ESTSS strategy to address mental health issues related to COVID-19 and focuses on (1) trauma-informed policies, (2) capacity building, (3) collaborative research and (4) knowledge-exchange. To facilitate implementation of a trauma-informed approach and appropriate measures, ESTSS has developed a toolkit of recommendations on mental health and psychosocial assistance to be provided during the different phases of crisis and its aftermath. To promote capacity building, ESTSS offers a certification programme based on a curriculum in psychotraumatology and corresponding on-line training to the European community of mental health professionals. To assure evidence-based approaches and methods tailored to current circumstances, ESTSS has initiated a pan-European research project with international cooperation aimed at studying the mental health consequences of the pandemic, with a focus on psychological trauma and other stress-related reactions. To foster knowledge-exchange, the European Journal of Psychotraumatology (EJPT), the official journal of ESTSS, is publishing a special issue on COVID-19.", "doi": "10.1080/20008198.2020.1780782", "pmid": "33029320", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "1780782"}, {"db": "pmc", "key": "PMC7473312"}], "notes": [], "created": "2020-12-01T17:34:45.142Z", "modified": "2020-12-01T17:34:45.155Z"}, {"entity": "publication", "iuid": "a63ed59e45d94da1911ac1a678510612", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a63ed59e45d94da1911ac1a678510612.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a63ed59e45d94da1911ac1a678510612"}}, "title": "In the Name of COVID-19: Is the ECB Fuelling the Climate Crisis?", "authors": [{"family": "Cojoianu", "given": "T F", "initials": "TF"}, {"family": "Collins", "given": "E", "initials": "E"}, {"family": "Hoepner", "given": "A G F", "initials": "AGF"}, {"family": "Magill", "given": "D", "initials": "D"}, {"family": "O'Neill", "given": "T", "initials": "T"}, {"family": "Schneider", "given": "F I", "initials": "FI"}], "type": "journal article", "published": "2020-07-09", "journal": {"title": "Environ Resour Econ (Dordr)", "issn": "0924-6460", "volume": null, "issue": null, "pages": "1-7", "issn-l": null}, "abstract": "We offer preliminary evidence drawing on a novel dataset of corporate bonds issued in the European energy sector since January 2020 in combination with the European Central Bank's (ECB) purchases under the Pandemic Emergency Purchase Programme (PEPP) in response to COVID-19. We show that the likelihood of a European energy company bond to be bought as part of the ECB's programme increases with the greenhouse gas (GHG) intensity of the bond issuing firm. We also find weaker evidence that the ECB's PEPP portfolio during the pandemic is likely to become tilted towards companies with anti-climate lobbying activities and companies with less transparent GHG emissions disclosure. Our findings imply that, at later stages of the COVID-19 recovery, an in-depth analysis may be necessary to understand if, and if yes why, the ECB fuelled the climate crisis.", "doi": "10.1007/s10640-020-00450-z", "pmid": "32836830", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "450"}, {"db": "pmc", "key": "PMC7343577"}], "notes": [], "created": "2020-12-07T10:39:12.359Z", "modified": "2020-12-07T10:39:12.371Z"}, {"entity": "publication", "iuid": "68675153e8e349be9fbde1c8a97ed2a5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68675153e8e349be9fbde1c8a97ed2a5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68675153e8e349be9fbde1c8a97ed2a5"}}, "title": "How Medical Studies in Poland Prepare Future Healthcare Managers for Crises and Disasters: Results of a Pilot Study.", "authors": [{"family": "Misztal-Oko\u0144ska", "given": "Patrycja", "initials": "P"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}, {"family": "Hertelendy", "given": "Attila J", "initials": "AJ"}, {"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}, {"family": "Al-Wathinani", "given": "Ahmed", "initials": "A"}, {"family": "Alhazmi", "given": "Riyadh A", "initials": "RA"}, {"family": "Goniewicz", "given": "Mariusz", "initials": "M"}], "type": "journal article", "published": "2020-07-09", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "issn-l": null, "volume": "8", "issue": "3", "pages": null}, "abstract": "In the event of a crisis, rapid and effective assistance for victims is essential, and in many cases, medical assistance is required. To manage the situation efficiently, it is necessary to have a proactive management system in place that ensures professional assistance to victims and the safety of medical personnel. We evaluated the perceptions of students and graduates in public health studies at the Medical University of Lublin, Poland, concerning their preparation and management skills for crises such as the COVID-19 pandemic. This pilot study was conducted in March 2020; we employed an online survey with an anonymous questionnaire that was addressed to students and graduates with an educational focus in healthcare organization and management. The study involved 55 people, including 14 men and 41 women. Among the respondents, 41.8% currently worked in a healthcare facility and only 21.7% of them had participated in training related to preparation for emergencies and disasters in their current workplace. The respondents rated their workplaces' preparedness for the COVID-19 pandemic at four points. A significant number of respondents stated that if they had to manage a public health emergency, they would not be able to manage the situation correctly and not be able to predict its development. Managers of healthcare organizations should have the knowledge and skills to manage crises. It would be advisable for them to have been formally educated in public health or healthcare administration. In every healthcare facility, it is essential that training and practice of performing medical procedures in full personal protective equipment (PPE) be provided. Healthcare facilities must implement regular training combined with practical live scenario exercises to prepare for future crises.", "doi": "10.3390/healthcare8030202", "pmid": "32659897", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "healthcare8030202"}, {"db": "pmc", "key": "PMC7551878"}], "notes": [], "created": "2020-12-08T10:45:49.117Z", "modified": "2022-11-10T07:38:24.769Z"}, {"entity": "publication", "iuid": "6530aa23a91f405dab1dffe84e6082a7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6530aa23a91f405dab1dffe84e6082a7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6530aa23a91f405dab1dffe84e6082a7"}}, "title": "Female Faculty: Why So Few and Why Care?", "authors": [{"family": "Kamerlin", "given": "Shina Caroline Lynn", "initials": "SCL"}, {"family": "Wittung-Stafshede", "given": "Pernilla", "initials": "P"}], "type": "journal article", "published": "2020-07-08", "journal": {"title": "Chemistry", "issn": "1521-3765", "volume": "26", "issue": "38", "pages": "8319-8323", "issn-l": null}, "abstract": "Despite slow ongoing progress in increasing the representation of women in academia, women remain significantly under-represented at senior levels, in particular in the natural sciences and engineering. Not infrequently, this is downplayed by bringing forth arguments such as inherent biological differences between genders, that current policies are adequate to address the issue, or by deflecting this as being \"not my problem\" among other examples. In this piece we present scientific evidence that counters these claims, as well as a best-practice example, Genie, from Chalmers University of Technology, where one of the authors is currently employed. We also highlight particular challenges caused by the current COVID-19 pandemic. Finally, we conclude by proposing some possible solutions to the situation and emphasize that we need to all do our part, to ensure that the next generation of academics experience a more diverse, inclusive, and equitable working environment.", "doi": "10.1002/chem.202002522", "pmid": "32583921", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-08T15:52:50.109Z", "modified": "2020-12-08T15:52:50.134Z"}, {"entity": "publication", "iuid": "65e3364e9e5d4f9a8a2d4ff3daef5d7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65e3364e9e5d4f9a8a2d4ff3daef5d7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65e3364e9e5d4f9a8a2d4ff3daef5d7a"}}, "title": "Conspiracy Beliefs Are Associated with Lower Knowledge and Higher Anxiety Levels Regarding COVID-19 among Students at the University of Jordan.", "authors": [{"family": "Sallam", "given": "Malik", "initials": "M"}, {"family": "Dababseh", "given": "Deema", "initials": "D"}, {"family": "Yaseen", "given": "Alaa'", "initials": "A"}, {"family": "Al-Haidar", "given": "Ayat", "initials": "A"}, {"family": "Ababneh", "given": "Nidaa A", "initials": "NA"}, {"family": "Bakri", "given": "Faris G", "initials": "FG"}, {"family": "Mahafzah", "given": "Azmi", "initials": "A"}], "type": "journal article", "published": "2020-07-08", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "14", "pages": null}, "abstract": "The world has been afflicted heavily by the burden of coronavirus disease 2019 (COVID-19) that overwhelmed health care systems and caused severe economic and educational deficits, in addition to anxiety among the public. The main aim of this study was to evaluate the mutual effects of belief that the pandemic was the result of a conspiracy on knowledge and anxiety levels among students at the University of Jordan (UJ). An electronic-based survey was conducted between 29 March, 2020 and 31 March, 2020. The targeted population involved all undergraduate and postgraduate students from the health, scientific and humanities schools at UJ. Survey sections included 26 items on: socio-demographic information, knowledge and sources of information about the disease, attitude towards the false notion that COVID-19 stemmed from a conspiracy and items to assess the anxiety level among students during the quarantine period. The total number of participants was 1540 students. The mean age of study participants was 22 years and females predominated the study population (n = 1145, 74.4%). The majority of participants perceived the disease as moderately dangerous (n = 1079, 70.1%). Males, Jordanians and participants with lower income were more inclined to feel that COVID-19 is very dangerous. A lower level of knowledge and a higher level of anxiety about COVID-19 were associated with the belief that the disease is part of a conspiracy. Females and participants with lower income were more likely to believe that the disease is related to conspiracy. Belief in conspiracy regarding the origin of COVID-19 was associated with misinformation about the availability of a vaccine and the therapeutic use of antibiotics for COVID-19 treatment. The Ministry of Health in Jordan was the most common source of information about COVID-19 reported by the participants (n = 1018). The false belief that COVID-19 was the result of a global conspiracy could be the consequence of a lower level of knowledge about the virus and could lead to a higher level of anxiety, which should be considered in the awareness tools of various media platforms about the current pandemic.", "doi": "10.3390/ijerph17144915", "pmid": "32650409", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "ijerph17144915"}, {"db": "pmc", "key": "PMC7399915"}], "notes": [], "created": "2020-12-08T14:17:45.329Z", "modified": "2022-11-10T07:40:15.463Z"}, {"entity": "publication", "iuid": "fb4d376b71a345b9aff49daecbc61a83", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb4d376b71a345b9aff49daecbc61a83.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb4d376b71a345b9aff49daecbc61a83"}}, "title": "Combination treatments with hydroxychloroquine and azithromycin are compatible with the therapeutic induction of anticancer immune responses.", "authors": [{"family": "Liu", "given": "Peng", "initials": "P"}, {"family": "Zhao", "given": "Liwei", "initials": "L"}, {"family": "Ferrere", "given": "Gladys", "initials": "G"}, {"family": "Alves-Costa-Silva", "given": "Carolina", "initials": "C"}, {"family": "Ly", "given": "Pierre", "initials": "P"}, {"family": "Wu", "given": "Qi", "initials": "Q"}, {"family": "Tian", "given": "Ai-Ling", "initials": "AL"}, {"family": "Derosa", "given": "Lisa", "initials": "L"}, {"family": "Zitvogel", "given": "Laurence", "initials": "L"}, {"family": "Kepp", "given": "Oliver", "initials": "O"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}], "type": "journal article", "published": "2020-07-08", "journal": {"title": "Oncoimmunology", "issn": "2162-4011", "volume": "9", "issue": "1", "pages": "1789284", "issn-l": null}, "abstract": "Amid controversial reports that COVID-19 can be treated with a combination of the antimalarial drug hydroxychloroquine (HCQ) and the antibiotic azithromycin (AZI), a clinical trial (ONCOCOVID, NCT04341207) was launched at Gustave Roussy Cancer Campus to investigate the utility of this combination therapy in cancer patients. In this preclinical study, we investigated whether the combination of HCQ+AZI would be compatible with the therapeutic induction of anticancer immune responses. For this, we used doses of HCQ and AZI that affect whole-body physiology (as indicated by a partial blockade in cardiac and hepatic autophagic flux for HCQ and a reduction in body weight for AZI), showing that their combined administration did not interfere with tumor growth control induced by the immunogenic cell death inducer oxaliplatin. Moreover, the HCQ+AZI combination did not affect the capacity of a curative regimen (cisplatin + crizotinib + PD-1 blockade) to eradicate established orthotopic lung cancers in mice. In conclusion, it appears that HCQ+AZI does not interfere with the therapeutic induction of therapeutic anticancer immune responses.", "doi": "10.1080/2162402X.2020.1789284", "pmid": "32923151", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "1789284"}, {"db": "pmc", "key": "PMC7458592"}], "notes": [], "created": "2020-12-03T15:36:32.115Z", "modified": "2021-02-26T08:45:03.362Z"}, {"entity": "publication", "iuid": "846ec4f0a2d84dc681ee8697ff6ea46c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/846ec4f0a2d84dc681ee8697ff6ea46c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/846ec4f0a2d84dc681ee8697ff6ea46c"}}, "title": "Wastewater-Based Epidemiology: Global Collaborative to Maximize Contributions in the Fight Against COVID-19.", "authors": [{"family": "Bivins", "given": "Aaron", "initials": "A"}, {"family": "North", "given": "Devin", "initials": "D"}, {"family": "Ahmad", "given": "Arslan", "initials": "A"}, {"family": "Ahmed", "given": "Warish", "initials": "W"}, {"family": "Alm", "given": "Eric", "initials": "E"}, {"family": "Been", "given": "Frederic", "initials": "F"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Bijlsma", "given": "Lubertus", "initials": "L"}, {"family": "Boehm", "given": "Alexandria B", "initials": "AB"}, {"family": "Brown", "given": "Joe", "initials": "J"}, {"family": "Buttiglieri", "given": "Gianluigi", "initials": "G"}, {"family": "Calabro", "given": "Vincenza", "initials": "V"}, {"family": "Carducci", "given": "Annalaura", "initials": "A"}, {"family": "Castiglioni", "given": "Sara", "initials": "S"}, {"family": "Cetecioglu Gurol", "given": "Zeynep", "initials": "Z"}, {"family": "Chakraborty", "given": "Sudip", "initials": "S"}, {"family": "Costa", "given": "Federico", "initials": "F"}, {"family": "Curcio", "given": "Stefano", "initials": "S"}, {"family": "de Los Reyes", "given": "Francis L", "initials": "FL"}, {"family": "Delgado Vela", "given": "Jeseth", "initials": "J"}, {"family": "Farkas", "given": "Kata", "initials": "K"}, {"family": "Fernandez-Casi", "given": "Xavier", "initials": "X"}, {"family": "Gerba", "given": "Charles", "initials": "C"}, {"family": "Gerrity", "given": "Daniel", "initials": "D"}, {"family": "Girones", "given": "Rosina", "initials": "R"}, {"family": "Gonzalez", "given": "Raul", "initials": "R"}, {"family": "Haramoto", "given": "Eiji", "initials": "E"}, {"family": "Harris", "given": "Angela", "initials": "A"}, {"family": "Holden", "given": "Patricia A", "initials": "PA"}, {"family": "Islam", "given": "Md Tahmidul", "initials": "MT"}, {"family": "Jones", "given": "Davey L", "initials": "DL"}, {"family": "Kasprzyk-Hordern", "given": "Barbara", "initials": "B"}, {"family": "Kitajima", "given": "Masaaki", "initials": "M"}, {"family": "Kotlarz", "given": "Nadine", "initials": "N"}, {"family": "Kumar", "given": "Manish", "initials": "M"}, {"family": "Kuroda", "given": "Keisuke", "initials": "K"}, {"family": "La Rosa", "given": "Giuseppina", "initials": "G"}, {"family": "Malpei", "given": "Francesca", "initials": "F"}, {"family": "Mautus", "given": "Mariana", "initials": "M"}, {"family": "McLellan", "given": "Sandra L", "initials": "SL"}, {"family": "Medema", "given": "Gertjan", "initials": "G"}, {"family": "Meschke", "given": "John Scott", "initials": "JS"}, {"family": "Mueller", "given": "Jochen", "initials": "J"}, {"family": "Newton", "given": "Ryan J", "initials": "RJ"}, {"family": "Nilsson", "given": "David", "initials": "D"}, {"family": "Noble", "given": "Rachel T", "initials": "RT"}, {"family": "van Nuijs", "given": "Alexander", "initials": "A"}, {"family": "Peccia", "given": "Jordan", "initials": "J"}, {"family": "Perkins", "given": "T Alex", "initials": "TA"}, {"family": "Pickering", "given": "Amy J", "initials": "AJ"}, {"family": "Rose", "given": "Joan", "initials": "J"}, {"family": "Sanchez", "given": "Gloria", "initials": "G"}, {"family": "Smith", "given": "Adam", "initials": "A"}, {"family": "Stadler", "given": "Lauren", "initials": "L"}, {"family": "Stauber", "given": "Christine", "initials": "C"}, {"family": "Thomas", "given": "Kevin", "initials": "K"}, {"family": "van der Voorn", "given": "Tom", "initials": "T"}, {"family": "Wigginton", "given": "Krista", "initials": "K"}, {"family": "Zhu", "given": "Kevin", "initials": "K"}, {"family": "Bibby", "given": "Kyle", "initials": "K"}], "type": "news", "published": "2020-07-07", "journal": {"title": "Environ Sci Technol", "issn": "1520-5851", "volume": "54", "issue": "13", "pages": "7754-7757", "issn-l": null}, "abstract": null, "doi": "10.1021/acs.est.0c02388", "pmid": "32530639", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7299382"}], "notes": [], "created": "2020-12-09T10:05:39.307Z", "modified": "2020-12-09T10:05:39.328Z"}, {"entity": "publication", "iuid": "6e381cbd252b437fa63080f76d62df4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e381cbd252b437fa63080f76d62df4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e381cbd252b437fa63080f76d62df4c"}}, "title": "Relationship Between Odor Intensity Estimates and COVID-19 Prevalence Prediction in a Swedish Population", "authors": [{"family": "Iravani", "given": "Behzad", "initials": "B", "orcid": "0000-0001-9905-1067", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5c799aeccef49a59531ad96984f466b.json"}}, {"family": "Arshamian", "given": "Artin", "initials": "A"}, {"family": "Ravia", "given": "Aharon", "initials": "A"}, {"family": "Mishor", "given": "Eva", "initials": "E"}, {"family": "Snitz", "given": "Kobi", "initials": "K"}, {"family": "Shushan", "given": "Sagit", "initials": "S"}, {"family": "Roth", "given": "Yehudah", "initials": "Y"}, {"family": "Perl", "given": "Ofer", "initials": "O"}, {"family": "Honigstein", "given": "Danielle", "initials": "D"}, {"family": "Weissgross", "given": "Reut", "initials": "R"}, {"family": "Karagach", "given": "Shiri", "initials": "S"}, {"family": "Ernst", "given": "Gernot", "initials": "G"}, {"family": "Okamoto", "given": "Masako", "initials": "M"}, {"family": "Mainen", "given": "Zachary", "initials": "Z"}, {"family": "Monteleone", "given": "Erminio", "initials": "E"}, {"family": "Dinnella", "given": "Caterina", "initials": "C"}, {"family": "Spinelli", "given": "Sara", "initials": "S"}, {"family": "Mari\u00f1o-S\u00e1nchez", "given": "Franklin", "initials": "F"}, {"family": "Ferdenzi", "given": "Camille", "initials": "C"}, {"family": "Smeets", "given": "Monique", "initials": "M"}, {"family": "Touhara", "given": "Kazushige", "initials": "K"}, {"family": "Bensafi", "given": "Moustafa", "initials": "M", "orcid": "0000-0002-2991-3036", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11b9f8b4dfbd4345ad03a0a694d5efcd.json"}}, {"family": "Hummel", "given": "Thomas", "initials": "T", "orcid": "0000-0001-9713-0183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/271198f0dc1f4b3fa9bef3d1225a24bf.json"}}, {"family": "Sobel", "given": "Noam", "initials": "N"}, {"family": "Lundstr\u00f6m", "given": "Johan N", "initials": "JN", "orcid": "0000-0002-3529-8981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a92f50aea024a1fbf0cfda979efef11.json"}}], "type": "journal-article", "published": "2020-07-07", "journal": {"title": "Chem Senses", "issn": "0379-864X", "volume": "45", "issue": "6", "pages": "449-456", "issn-l": null}, "abstract": "In response to the COVID-19 pandemic, countries have implemented various strategies to reduce and slow the spread of the disease in the general population. For countries that have implemented restrictions on its population in a step-wise manner, monitoring of COVID-19 prevalence is of importance to guide decision on when to impose new, or when to abolish old, restrictions. We are here determining whether measures of odor intensity in a large sample can serve as one such measure. Online measures of how intense common household odors are perceived and symptoms of COVID-19 were collected from 2440 Swedes. Average odor intensity ratings were then compared to predicted COVID-19 population prevalence over time in the Swedish population and were found to closely track each other (r=-0.83). Moreover, we found that there was a large difference in rated intensity between individuals with and without COVID-19 symptoms and number of symptoms was related to odor intensity ratings. Finally, we found that individuals progressing from reporting no symptoms to subsequently reporting COVID-19 symptoms demonstrated a large drop in olfactory performance. These data suggest that measures of odor intensity, if obtained in a large and representative sample, can be used as an indicator of COVID-19 disease in the general population. Importantly, this simple measure could easily be implemented in countries without widespread access to COVID-19 testing or implemented as a fast early response before wide-spread testing can be facilitated.", "doi": "10.1093/chemse/bjaa034", "pmid": "32441744", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "5842049"}, {"db": "pmc", "key": "PMC7314115"}], "notes": [], "created": "2020-11-25T09:11:13.432Z", "modified": "2021-12-06T13:17:58.519Z"}, {"entity": "publication", "iuid": "46bea90f079749b5acc9ceed9a2570f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46bea90f079749b5acc9ceed9a2570f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46bea90f079749b5acc9ceed9a2570f9"}}, "title": "Has Venoarterial ECMO Been Underutilized in COVID-19 Patients?", "authors": [{"family": "De Piero", "given": "Maria Elena", "initials": "ME"}, {"family": "Lo Coco", "given": "Valeria", "initials": "V"}, {"family": "Taccone", "given": "Fabio Silvio", "initials": "FS"}, {"family": "Belliato", "given": "Mirko", "initials": "M"}, {"family": "Broman", "given": "Lars M", "initials": "LM"}, {"family": "Malfertheiner", "given": "Maximilian V", "initials": "MV"}, {"family": "Lorusso", "given": "Roberto", "initials": "R"}], "type": "editorial", "published": "2020-07-07", "journal": {"title": "Innovations (Phila)", "issn": "1559-0879", "volume": "15", "issue": "4", "pages": "317-321", "issn-l": null}, "abstract": null, "doi": "10.1177/1556984520939076", "pmid": "32634058", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-08T14:36:09.388Z", "modified": "2020-12-08T14:36:09.411Z"}, {"entity": "publication", "iuid": "0ad3e7bd357b483e955e3a096d969e77", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ad3e7bd357b483e955e3a096d969e77.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ad3e7bd357b483e955e3a096d969e77"}}, "title": "European consensus recommendations for neonatal and paediatric retrievals of positive or suspected COVID-19 patients.", "authors": [{"family": "Terheggen", "given": "Ulrich", "initials": "U"}, {"family": "Heiring", "given": "Christian", "initials": "C"}, {"family": "Kjellberg", "given": "Mattias", "initials": "M"}, {"family": "Hegardt", "given": "Fredrik", "initials": "F"}, {"family": "Kneyber", "given": "Martin", "initials": "M"}, {"family": "Gente", "given": "Maurizio", "initials": "M"}, {"family": "Roehr", "given": "Charles C", "initials": "CC"}, {"family": "Jourdain", "given": "Gilles", "initials": "G"}, {"family": "Tissieres", "given": "Pierre", "initials": "P"}, {"family": "Ramnarayan", "given": "Padmanabhan", "initials": "P"}, {"family": "Breindahl", "given": "Morten", "initials": "M"}, {"family": "van den Berg", "given": "Johannes", "initials": "J"}], "type": "journal article", "published": "2020-07-07", "journal": {"title": "Pediatr Res", "issn": "1530-0447", "volume": null, "issue": null, "pages": null, "issn-l": "0031-3998"}, "abstract": "The 2020 novel coronavirus (SARS-Cov-2) pandemic necessitates tailored recommendations addressing specific procedures for neonatal and paediatric transport of suspected or positive COVID-19 patients. The aim of this consensus statement is to define guidelines for safe clinical care for children needing inter-facility transport while making sure that the clinical teams involved are sufficiently protected from SARS-CoV-2.\r\n\r\nA taskforce, composed of members of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC) Transport section and the European Society for Paediatric Research (ESPR), reviewed the published literature and used a rapid, two-step modified Delphi process to formulate recommendations regarding safety and clinical management during transport of COVID-19 patients.\r\n\r\nThe joint taskforce consisted of a panel of 12 experts who reached an agreement on a set of 17 recommendations specifying pertinent aspects on neonatal and paediatric COVID-19 patient transport. These included: case definition, personal protective equipment, airway management, equipment and strategies for invasive and non-invasive ventilation, special considerations for incubator and open stretcher transports, parents on transport and decontamination of transport vehicles.\r\n\r\nOur consensus recommendations aim to define current best-practice and should help guide transport teams dealing with infants and children with COVID-19 to work safely and effectively.\r\n\r\nWe present European consensus recommendations on pertinent measures for transporting infants and children in times of the coronavirus (SARS-Cov-2 /COVID-19) pandemic.A panel of experts reviewed the evidence around transporting infants and children with proven or suspected COVID-19. Specific guidance on aspects of personal protective equipment, airway management and considerations for incubator and open stretcher transports is presented.Based on scant evidence, best-practice recommendations for neonatal and paediatric transport teams are presented, aiming for the protection of teams and patients. We highlight gaps in knowledge and areas of future research.", "doi": "10.1038/s41390-020-1050-z", "pmid": "32634819", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41390-020-1050-z"}], "notes": [], "created": "2020-11-19T14:31:03.050Z", "modified": "2020-11-30T08:51:26.698Z"}, {"entity": "publication", "iuid": "9f4418e203d646a3aea9f4da8d915c56", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f4418e203d646a3aea9f4da8d915c56.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f4418e203d646a3aea9f4da8d915c56"}}, "title": "Complete protection from covid-19 is possible for health workers.", "authors": [{"family": "Karlsson", "given": "Ulf", "initials": "U"}, {"family": "Fraenkel", "given": "Carl-Johan", "initials": "CJ"}], "type": "editorial", "published": "2020-07-07", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "370", "issue": null, "pages": "m2641", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m2641", "pmid": "32636186", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-08T14:30:49.116Z", "modified": "2020-12-08T14:30:49.127Z"}, {"entity": "publication", "iuid": "f9d8dc3406334b78bbea45064cff29ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f9d8dc3406334b78bbea45064cff29ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f9d8dc3406334b78bbea45064cff29ee"}}, "title": "[The virtual ward - the students' clinical education during the current pandemic].", "authors": [{"family": "Robertson", "given": "Josefina", "initials": "J"}, {"family": "Ahlgren", "given": "Erika", "initials": "E"}, {"family": "Rydberg", "given": "Frida", "initials": "F"}, {"family": "Snygg-Martin", "given": "Ulrika", "initials": "U"}, {"family": "Westin", "given": "Johan", "initials": "J"}, {"family": "Studahl", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2020-07-06", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "volume": "117", "issue": null, "issn-l": "0023-7205"}, "abstract": "On March 17, 2020, the Swedish Government recommended all higher education institutions to move to online and distance learning during the COVID-19 pandemic. The integrated course in Infection, Microbiology, and Immunity at the Programme in Medicine at University of Gothenburg had to be completely transformed. Creative solutions have now replaced the clinical training that normally takes place during the students' clinical education at the hospital. We developed a digital concept entitled \"the virtual ward\", in which we interact with the students in real time. Here, the students are able to follow their patients on a daily basis during teacher-guided sessions.", "doi": null, "pmid": "32633809", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "20077"}], "notes": [], "created": "2020-12-08T14:39:33.360Z", "modified": "2020-12-08T14:39:33.372Z"}, {"entity": "publication", "iuid": "8b1c4e0ddc2441c08331bc2a0429303d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b1c4e0ddc2441c08331bc2a0429303d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b1c4e0ddc2441c08331bc2a0429303d"}}, "title": "Why policy action should focus on the vulnerable commercial sex workers in Uganda during COVID-19 fight.", "authors": [{"family": "Kawala", "given": "Brenda Allen", "initials": "BA"}, {"family": "Kirui", "given": "Brian Kibiwott", "initials": "BK"}, {"family": "Cumber", "given": "Samuel Nambile", "initials": "SN"}], "type": "letter", "published": "2020-07-06", "journal": {"title": "Pan Afr Med J", "issn": "1937-8688", "volume": "35", "issue": "Suppl 2", "pages": "102", "issn-l": null}, "abstract": null, "doi": "10.11604/pamj.supp.2020.35.2.24664", "pmid": "33282057", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "PAMJ-SUPP-35-2-102"}, {"db": "pmc", "key": "PMC7687465"}], "notes": [], "created": "2020-12-10T09:18:47.080Z", "modified": "2020-12-10T09:18:47.091Z"}, {"entity": "publication", "iuid": "7207513ff7874785b676fa1a4be24ddb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7207513ff7874785b676fa1a4be24ddb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7207513ff7874785b676fa1a4be24ddb"}}, "title": "Anti-coagulation for COVID-19 treatment: both anti-thrombotic and anti-inflammatory?", "authors": [{"family": "Paar", "given": "Vera", "initials": "V"}, {"family": "Wernly", "given": "Bernhard", "initials": "B"}, {"family": "Zhou", "given": "Zhichao", "initials": "Z"}, {"family": "Motloch", "given": "Lukas J", "initials": "LJ"}, {"family": "Hoppe", "given": "Uta C", "initials": "UC"}, {"family": "Egle", "given": "Alexander", "initials": "A"}, {"family": "Lichtenauer", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2020-07-06", "journal": {"title": "J Thromb Thrombolysis", "issn": "1573-742X", "volume": null, "issue": null, "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has been linked to a higher risk of mortality compared to influenza, which is mainly due to severe secondary diseases, such as acute respiratory distress syndrome (ARDS). In turn, ARDS is characterized by an acute inflammation and an excessive activity of the coagulation cascade, rising the vulnerability for venous thromboembolic events. In order to investigate the relation of inflammation and the influence of coagulation factors on their release, human peripheral mononuclear blood cells (PBMCs) were treated with autologous serum, heparinized plasma and different doses of fibrin. Thereafter, the concentration of pro-inflammatory cytokines and chemokines in the secretome of PBMCs was measured by enzyme-linked immunosorbent assay. Our analyses revealed autologous serum to significantly increase the secretion of cytokines and chemokines after 24 h of incubation time. Furthermore, the addition of fibrin markedly increased the secretion of cytokines and chemokines by PBMCs in a dose-dependent manner. Consequently, in accordance with previous studies, our study outlines that anti-coagulation may constitute a promising tool for the treatment of SARS-CoV-2, reducing both, the cytokine storm, as well as the risk for thrombotic complications.", "doi": "10.1007/s11239-020-02212-6", "pmid": "32632558", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11239-020-02212-6"}, {"db": "pmc", "key": "PMC7338133"}], "notes": [], "created": "2020-12-08T14:40:18.189Z", "modified": "2021-02-26T08:45:03.055Z"}, {"entity": "publication", "iuid": "ab46cb3b389f498e9f66c700d13ce759", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ab46cb3b389f498e9f66c700d13ce759.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ab46cb3b389f498e9f66c700d13ce759"}}, "title": "A Silent Infection Pandemic of COVID-19: Epidemiological Investigation and Hypothetical Models.", "authors": [{"family": "Geng", "given": "Jianping", "initials": "J"}, {"family": "Yu", "given": "Jun", "initials": "J", "orcid": "0000-0003-2006-758X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30dd1b66e1284ab1aa3566ab21556595.json"}}, {"family": "Lu", "given": "Tao", "initials": "T"}, {"family": "Wang", "given": "Yinhe", "initials": "Y"}, {"family": "Cao", "given": "Yang", "initials": "Y", "orcid": "0000-0002-3552-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7594ca0fdf2d4f238ca04a788a405cdb.json"}}], "type": "journal article", "published": "2020-07-05", "journal": {"title": "Can J Infect Dis Med Microbiol", "issn": "1712-9532", "volume": "2020", "issue": null, "pages": "5120253", "issn-l": null}, "abstract": "To explore the epidemic mode of COVID-19, we made an epidemiological investigation, set up hypothetical models, and compared them with hepatitis A virus (HAV) age-specific epidemic characteristic. In the epidemiological investigation, we reported the first familial COVID-19 silent infection in the world. A 19-year-old healthy female COVID-19 virus carrier without any symptoms caused two mild and one severe pneumonia. In hypothetical models, the silent infection rate ranges from 60% to 80% based on 3 sources: China mainland, evacuation of 4 nationals, and the ship \"Diamond Princess,\" respectively. In comparison with HAV, COVID-19 shows the same infection mode in children (aged 0-9 years), but significant difference in young adults (aged 10-44 years) and the elderly (aged 45 years or older). Therefore, we prejudged that COVID-19 is a silent infection pandemic mainly in young adults but threatens the elderly.", "doi": "10.1155/2020/5120253", "pmid": "32670439", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7341389"}], "notes": [], "created": "2020-12-07T16:37:05.988Z", "modified": "2023-06-19T14:36:40.335Z"}, {"entity": "publication", "iuid": "9c6f1f68c72547ee948469c8d27d2ff3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9c6f1f68c72547ee948469c8d27d2ff3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9c6f1f68c72547ee948469c8d27d2ff3"}}, "title": "Rapid Detection of COVID-19 Coronavirus Using a Reverse Transcriptional Loop-Mediated Isothermal Amplification (RT-LAMP) Diagnostic Platform", "authors": [{"family": "Yu", "given": "Lin", "initials": "L"}, {"family": "Wu", "given": "Shanshan", "initials": "S"}, {"family": "Hao", "given": "Xiaowen", "initials": "X"}, {"family": "Dong", "given": "Xue", "initials": "X"}, {"family": "Mao", "given": "Lingling", "initials": "L"}, {"family": "Pelechano", "given": "Vicent", "initials": "V"}, {"family": "Chen", "given": "Wei Hua", "initials": "WH"}, {"family": "Yin", "given": "Xiushan", "initials": "X"}], "type": "journal-article", "published": "2020-07-01", "journal": {"title": "Clin Chem", "issn": "0009-9147", "issn-l": null, "volume": "66", "issue": "7", "pages": "975-977"}, "abstract": null, "doi": "10.1093/clinchem/hvaa102", "pmid": "32315390", "labels": {"Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Research Area: Diagnostics for virus": null, "Funder: VR": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "5823294"}, {"db": "pmc", "key": "PMC7188121"}], "notes": [], "created": "2020-11-04T07:17:58.514Z", "modified": "2022-02-14T06:39:01.697Z"}, {"entity": "publication", "iuid": "7c12e4c6f6564264835fcdd9ee827c45", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7c12e4c6f6564264835fcdd9ee827c45.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7c12e4c6f6564264835fcdd9ee827c45"}}, "title": "Managing COVID-19 spread with voluntary public-health measures: Sweden as a case study for pandemic control.", "authors": [{"family": "Kamerlin", "given": "Shina C L", "initials": "SCL"}, {"family": "Kasson", "given": "Peter M", "initials": "PM"}], "type": "journal article", "published": "2020-07-01", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "issn-l": "1058-4838", "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic has spread globally, causing extensive illness and mortality. In advance of effective antiviral therapies, countries have applied different public-health strategies to control spread and manage healthcare need. Sweden has taken a unique approach of not implementing strict closures, instead urging personal responsibility. We analyze the results of this and other potential strategies for pandemic control in Sweden.\r\n\r\nWe implemented individual-based modeling of COVID-19 spread in Sweden using population, employment, and household data. Epidemiological parameters for COVID-19 were validated on a limited date range; where substantial uncertainties remained, multiple parameters were tested. The effects of different public-health strategies were tested over a 160-day period, analyzed for their effects on ICU demand and death rate, and compared to Swedish data for April 2020.\r\n\r\nSwedish mortality rates fall intermediate between European countries that quickly imposed stringent public-health controls and countries that acted later. Models most closely reproducing reported mortality data suggest large portions of the population voluntarily self-isolate. Swedish ICU utilization rates remained lower than predicted, but a large fraction of deaths occurred in non-ICU patients. This suggests that patient prognosis was considered in ICU admission, reducing healthcare load at a cost of decreased survival in patients not admitted.\r\n\r\nThe Swedish COVID-19 strategy has thus far yielded a striking result: mild mandates overlaid with voluntary measures can achieve results highly similar to late-onset stringent mandates. However, this policy causes more healthcare demand and mortality than early stringent control and depends on continued public will.", "doi": "10.1093/cid/ciaa864", "pmid": "32609825", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "5866094"}, {"db": "pmc", "key": "PMC7337695"}], "notes": [], "created": "2020-12-08T15:22:07.519Z", "modified": "2022-11-10T07:46:04.133Z"}, {"entity": "publication", "iuid": "541e95e5a6334de69e1c372342eaaf59", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/541e95e5a6334de69e1c372342eaaf59.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/541e95e5a6334de69e1c372342eaaf59"}}, "title": "Utilitarianism and the pandemic.", "authors": [{"family": "Savulescu", "given": "Julian", "initials": "J"}, {"family": "Persson", "given": "Ingmar", "initials": "I"}, {"family": "Wilkinson", "given": "Dominic", "initials": "D"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Bioethics", "issn": "1467-8519", "volume": "34", "issue": "6", "pages": "620-632", "issn-l": null}, "abstract": "There are no egalitarians in a pandemic. The scale of the challenge for health systems and public policy means that there is an ineluctable need to prioritize the needs of the many. It is impossible to treat all citizens equally, and a failure to carefully consider the consequences of actions could lead to massive preventable loss of life. In a pandemic there is a strong ethical need to consider how to do most good overall. Utilitarianism is an influential moral theory that states that the right action is the action that is expected to produce the greatest good. It offers clear operationalizable principles. In this paper we provide a summary of how utilitarianism could inform two challenging questions that have been important in the early phase of the pandemic: (a) Triage: which patients should receive access to a ventilator if there is overwhelming demand outstripping supply? (b) Lockdown: how should countries decide when to implement stringent social restrictions, balancing preventing deaths from COVID-19 with causing deaths and reductions in well-being from other causes? Our aim is not to argue that utilitarianism is the only relevant ethical theory, or in favour of a purely utilitarian approach. However, clearly considering which options will do the most good overall will help societies identify and consider the necessary cost of other values. Societies may choose either to embrace or not to embrace the utilitarian course, but with a clear understanding of the values involved and the price they are willing to pay.", "doi": "10.1111/bioe.12771", "pmid": "32433782", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7276855"}], "notes": [], "created": "2020-12-09T11:36:17.611Z", "modified": "2020-12-09T11:36:17.636Z"}, {"entity": "publication", "iuid": "a43e85c7b8bd42f98fbfd6c4a67d3a83", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a43e85c7b8bd42f98fbfd6c4a67d3a83.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a43e85c7b8bd42f98fbfd6c4a67d3a83"}}, "title": "Uncovering the Devaluation of Nursing Home Staff During COVID-19: Are We Fuelling the Next Health Care Crisis?", "authors": [{"family": "McGilton", "given": "Katherine S", "initials": "KS"}, {"family": "Escrig-Pinol", "given": "Astrid", "initials": "A"}, {"family": "Gordon", "given": "Adam", "initials": "A"}, {"family": "Chu", "given": "Charlene H", "initials": "CH"}, {"family": "Z\u00fa\u00f1iga", "given": "Franziska", "initials": "F"}, {"family": "Sanchez", "given": "Montserrat Gea", "initials": "MG"}, {"family": "Boscart", "given": "Veronique", "initials": "V"}, {"family": "Meyer", "given": "Julienne", "initials": "J"}, {"family": "Corazzini", "given": "Kirsten N", "initials": "KN"}, {"family": "Jacinto", "given": "Alessandro Ferrari", "initials": "AF"}, {"family": "Spilsbury", "given": "Karen", "initials": "K"}, {"family": "Backman", "given": "Annica", "initials": "A"}, {"family": "Scales", "given": "Kezia", "initials": "K"}, {"family": "Fagertun", "given": "Anette", "initials": "A"}, {"family": "Wu", "given": "Bei", "initials": "B"}, {"family": "Edvardsson", "given": "David", "initials": "D"}, {"family": "Lepore", "given": "Michael J", "initials": "MJ"}, {"family": "Leung", "given": "Angela Y M", "initials": "AYM"}, {"family": "Siegel", "given": "Elena O", "initials": "EO"}, {"family": "Noguchi-Watanabe", "given": "Maiko", "initials": "M"}, {"family": "Wang", "given": "Jing", "initials": "J"}, {"family": "Bowers", "given": "Barbara", "initials": "B"}], "type": "editorial", "published": "2020-07-00", "journal": {"title": "J Am Med Dir Assoc", "issn": "1538-9375", "volume": "21", "issue": "7", "pages": "962-965", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jamda.2020.06.010", "pmid": "32674829", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1525-8610(20)30492-8"}, {"db": "pmc", "key": "PMC7287421"}], "notes": [], "created": "2020-12-07T16:36:02.866Z", "modified": "2020-12-07T16:36:02.876Z"}, {"entity": "publication", "iuid": "280d2226abe54b8989ec40218181f134", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/280d2226abe54b8989ec40218181f134.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/280d2226abe54b8989ec40218181f134"}}, "title": "Unconventional Answers to Unprecedented Challenges: The Swedish Experience During the COVID-19 Outbreak.", "authors": [{"family": "Valeriani", "given": "Giuseppe", "initials": "G"}, {"family": "Vukovic", "given": "Iris Sarajlic", "initials": "IS"}, {"family": "Mollica", "given": "Richard", "initials": "R"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "J Prev Med Public Health", "issn": "2233-4521", "volume": "53", "issue": "4", "pages": "233-235", "issn-l": null}, "abstract": "Since its early stages, the coronavirus disease 2019 (COVID-19) pandemic has posed immense challenges in meeting the public health and healthcare and social care needs of migrants. In line with other reports from United Kingdom and United States, data from Sweden's health authority show that migrants have been disproportionately affected by COVID-19. Following the World Health Organization's statements, as well as the European Public Health Association's call for action, several centres in Sweden's most populated areas have activated tools to implement national plans for community outreach through initiatives targeting migrants and ethnic minority groups. Unconventional means should be promoted to mitigate the impact of COVID-19 on migrants and the health of the public at large.", "doi": "10.3961/jpmph.20.235", "pmid": "32752592", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jpmph.20.235"}, {"db": "pmc", "key": "PMC7411250"}], "notes": [], "created": "2020-11-30T08:44:12.012Z", "modified": "2020-11-30T08:44:12.036Z"}, {"entity": "publication", "iuid": "12b4dcc8dc3f4da3aa0981fb96c7e217", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/12b4dcc8dc3f4da3aa0981fb96c7e217.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/12b4dcc8dc3f4da3aa0981fb96c7e217"}}, "title": "The protein expression profile of ACE2 in human tissues.", "authors": [{"family": "Hikmet", "given": "Feria", "initials": "F", "orcid": "0000-0002-3750-9308", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/511acd3a0f344f119d0986f304edda13.json"}}, {"family": "M\u00e9ar", "given": "Loren", "initials": "L"}, {"family": "Edvinsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Micke", "given": "Patrick", "initials": "P"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cfef77b64f644d498532e5e2572a8c5c.json"}}, {"family": "Lindskog", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-5611-1015", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4ead3d38a364b66ac069b9c8bf63897.json"}}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Mol Syst Biol", "issn": "1744-4292", "issn-l": "1744-4292", "volume": "16", "issue": "7", "pages": "e9610"}, "abstract": "The novel SARS-coronavirus 2 (SARS-CoV-2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS-CoV-2 infection, the cell type-specific expression of the host cell surface receptor is necessary. The key protein suggested to be involved in host cell entry is angiotensin I converting enzyme 2 (ACE2). Here, we report the expression pattern of ACE2 across > 150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis. The results were compared with several datasets both on the mRNA and protein level. ACE2 expression was mainly observed in enterocytes, renal tubules, gallbladder, cardiomyocytes, male reproductive cells, placental trophoblasts, ductal cells, eye, and vasculature. In the respiratory system, the expression was limited, with no or only low expression in a subset of cells in a few individuals, observed by one antibody only. Our data constitute an important resource for further studies on SARS-CoV-2 host cell entry, in order to understand the biology of the disease and to aid in the development of effective treatments to the viral infection.", "doi": "10.15252/msb.20209610", "pmid": "32715618", "labels": {"Category: Biochemistry": null, "Category: Proteins": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7383091"}], "notes": [], "created": "2021-06-14T14:56:19.700Z", "modified": "2021-11-26T09:46:31.768Z"}, {"entity": "publication", "iuid": "49eeff9c7fc148e1b2f90ac1722df1c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49eeff9c7fc148e1b2f90ac1722df1c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49eeff9c7fc148e1b2f90ac1722df1c5"}}, "title": "The potential long-term impact of the COVID-19 outbreak on patients with non-communicable diseases in Europe: consequences for healthy ageing.", "authors": [{"family": "Palmer", "given": "Katie", "initials": "K"}, {"family": "Monaco", "given": "Alessandro", "initials": "A"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Onder", "given": "Graziano", "initials": "G"}, {"family": "Maggi", "given": "Stefania", "initials": "S"}, {"family": "Michel", "given": "Jean-Pierre", "initials": "JP"}, {"family": "Prieto", "given": "Rita", "initials": "R"}, {"family": "Sykara", "given": "Georgia", "initials": "G"}, {"family": "Donde", "given": "Shaantanu", "initials": "S"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Aging Clin Exp Res", "issn": "1720-8319", "volume": "32", "issue": "7", "pages": "1189-1194", "issn-l": "1594-0667"}, "abstract": "The early stages of the COVID-19 pandemic have focused on containing SARS-CoV-2 infection and identifying treatment strategies. While controlling this communicable disease is of utmost importance, the long-term effect on individuals with non-communicable diseases (NCD) is significant. Although certain NCDs appear to increase the severity of COVID-19 and mortality risk, SARS-CoV-2 infection in survivors with NCDs may also affect the progression of their pre-existing clinical conditions. Infection containment measures will have substantial short- and long-term consequences; social distancing and quarantine restrictions will reduce physical activity and increase other unhealthy lifestyles, thus increasing NCD risk factors and worsening clinical symptoms. Vitamin D levels might decrease and there might be a rise in mental health disorders. Many countries have made changes to routine management of NCD patients, e.g., cancelling non-urgent outpatient visits, which will have important implications for NCD management, diagnosis of new-onset NCDs, medication adherence, and NCD progression. We may have opportunities to learn from this unprecedented crisis on how to leverage healthcare technologies and improve procedures to optimize healthcare service provision. This article discusses how the COVID-19 outbreak and related infection control measures could hit the most frail individuals, worsening the condition of NCD patients, while further jeopardizing the sustainability of the healthcare systems. We suggest ways to define an integrated strategy that could involve both public institutional entities and the private sector to safeguard frail individuals and mitigate the impact of the outbreak.", "doi": "10.1007/s40520-020-01601-4", "pmid": "32458356", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40520-020-01601-4"}, {"db": "pmc", "key": "PMC7248450"}], "notes": [], "created": "2020-11-25T09:17:28.876Z", "modified": "2020-11-30T09:02:33.085Z"}, {"entity": "publication", "iuid": "c81e59dc42e44e30a7c6de749c714271", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c81e59dc42e44e30a7c6de749c714271.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c81e59dc42e44e30a7c6de749c714271"}}, "title": "The Vascular Surgery COVID-19 Collaborative (VASCC).", "authors": [{"family": "Mouawad", "given": "Nicolas J", "initials": "NJ"}, {"family": "Cuff", "given": "Robert F", "initials": "RF"}, {"family": "Hultgren", "given": "Rebecka", "initials": "R"}, {"family": "Chuen", "given": "Jason", "initials": "J"}, {"family": "Galeazzi", "given": "Edoardo", "initials": "E"}, {"family": "Wohlauer", "given": "Max", "initials": "M"}], "type": "letter", "published": "2020-07-00", "journal": {"title": "J Vasc Surg", "issn": "1097-6809", "volume": "72", "issue": "1", "pages": "379-380", "issn-l": "0741-5214"}, "abstract": "Letter to the editor", "doi": "10.1016/j.jvs.2020.04.463", "pmid": "32334050", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0741-5214(20)31054-5"}, {"db": "pmc", "key": "PMC7175883"}], "notes": [], "created": "2020-11-23T11:51:10.065Z", "modified": "2020-12-09T14:58:38.311Z"}, {"entity": "publication", "iuid": "c5ba8db7add244e7afb0dc120c5eef53", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5ba8db7add244e7afb0dc120c5eef53.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5ba8db7add244e7afb0dc120c5eef53"}}, "title": "The Use of eHealth for the Care of Patients With Diabetes in Connection to the COVID-19 Pandemic.", "authors": [{"family": "Jendle", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "J Diabetes Sci Technol", "issn": "1932-2968", "volume": "14", "issue": "4", "pages": "739-740", "issn-l": null}, "abstract": null, "doi": "10.1177/1932296820922623", "pmid": "32375494", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7673160"}], "notes": [], "created": "2020-12-10T07:34:11.628Z", "modified": "2020-12-10T07:34:20.300Z"}, {"entity": "publication", "iuid": "0a8b001724604a96921c186e67b47605", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a8b001724604a96921c186e67b47605.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a8b001724604a96921c186e67b47605"}}, "title": "The COronavirus Pandemic Epidemiology (COPE) Consortium: A Call to Action.", "authors": [{"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Nguyen", "given": "Long H", "initials": "LH"}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Guo", "given": "Chuan-Guo", "initials": "CG"}, {"family": "Lo", "given": "Chun-Han", "initials": "CH"}, {"family": "Mehta", "given": "Raaj S", "initials": "RS"}, {"family": "Kwon", "given": "Sohee", "initials": "S"}, {"family": "Sikavi", "given": "Daniel R", "initials": "DR"}, {"family": "Magicheva-Gupta", "given": "Marina V", "initials": "MV"}, {"family": "Fatehi", "given": "Zahra S", "initials": "ZS"}, {"family": "Flynn", "given": "Jacqueline J", "initials": "JJ"}, {"family": "Leonardo", "given": "Brianna M", "initials": "BM"}, {"family": "Albert", "given": "Christine M", "initials": "CM"}, {"family": "Andreotti", "given": "Gabriella", "initials": "G"}, {"family": "Beane-Freeman", "given": "Laura E", "initials": "LE"}, {"family": "Balasubramanian", "given": "Bijal A", "initials": "BA"}, {"family": "Brownstein", "given": "John S", "initials": "JS"}, {"family": "Bruinsma", "given": "Fiona", "initials": "F"}, {"family": "Cowan", "given": "Annie N", "initials": "AN"}, {"family": "Deka", "given": "Anusila", "initials": "A"}, {"family": "Ernst", "given": "Michael E", "initials": "ME"}, {"family": "Figueiredo", "given": "Jane C", "initials": "JC"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Gardner", "given": "Christopher D", "initials": "CD"}, {"family": "Ghobrial", "given": "Irene M", "initials": "IM"}, {"family": "Haiman", "given": "Christopher A", "initials": "CA"}, {"family": "Hall", "given": "Janet E", "initials": "JE"}, {"family": "Deming-Halverson", "given": "Sandra L", "initials": "SL"}, {"family": "Kirpach", "given": "Brenda", "initials": "B"}, {"family": "Lacey", "given": "James V", "initials": "JV"}, {"family": "Marchand", "given": "Lo\u00efc Le", "initials": "LL"}, {"family": "Marinac", "given": "Catherine R", "initials": "CR"}, {"family": "Martinez", "given": "Maria Elena", "initials": "ME"}, {"family": "Milne", "given": "Roger L", "initials": "RL"}, {"family": "Murray", "given": "Anne M", "initials": "AM"}, {"family": "Nash", "given": "Denis", "initials": "D"}, {"family": "Palmer", "given": "Julie R", "initials": "JR"}, {"family": "Patel", "given": "Alpa V", "initials": "AV"}, {"family": "Rosenberg", "given": "Lynn", "initials": "L"}, {"family": "Sandler", "given": "Dale P", "initials": "DP"}, {"family": "Sharma", "given": "Shreela V", "initials": "SV"}, {"family": "Schurman", "given": "Shepherd H", "initials": "SH"}, {"family": "Wilkens", "given": "Lynne R", "initials": "LR"}, {"family": "Chavarro", "given": "Jorge E", "initials": "JE"}, {"family": "Eliassen", "given": "A Heather", "initials": "AH"}, {"family": "Hart", "given": "Jaime E", "initials": "JE"}, {"family": "Kang", "given": "Jae Hee", "initials": "JH"}, {"family": "Koenen", "given": "Karestan C", "initials": "KC"}, {"family": "Kubzansky", "given": "Laura D", "initials": "LD"}, {"family": "Mucci", "given": "Lorelei A", "initials": "LA"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Rich-Edwards", "given": "Janet W", "initials": "JW"}, {"family": "Song", "given": "Mingyang", "initials": "M"}, {"family": "Stampfer", "given": "Meir J", "initials": "MJ"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Willett", "given": "Walter C", "initials": "WC"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Spector", "given": "Tim", "initials": "T"}, {"family": "COPE Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Cancer Epidemiol Biomarkers Prev", "issn": "1538-7755", "volume": "29", "issue": "7", "pages": "1283-1289", "issn-l": null}, "abstract": "The rapid pace of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; COVID-19) pandemic presents challenges to the real-time collection of population-scale data to inform near-term public health needs as well as future investigations. We established the COronavirus Pandemic Epidemiology (COPE) consortium to address this unprecedented crisis on behalf of the epidemiology research community. As a central component of this initiative, we have developed a COVID Symptom Study (previously known as the COVID Symptom Tracker) mobile application as a common data collection tool for epidemiologic cohort studies with active study participants. This mobile application collects information on risk factors, daily symptoms, and outcomes through a user-friendly interface that minimizes participant burden. Combined with our efforts within the general population, data collected from nearly 3 million participants in the United States and United Kingdom are being used to address critical needs in the emergency response, including identifying potential hot spots of disease and clinically actionable risk factors. The linkage of symptom data collected in the app with information and biospecimens already collected in epidemiology cohorts will position us to address key questions related to diet, lifestyle, environmental, and socioeconomic factors on susceptibility to COVID-19, clinical outcomes related to infection, and long-term physical, mental health, and financial sequalae. We call upon additional epidemiology cohorts to join this collective effort to strengthen our impact on the current health crisis and generate a new model for a collaborative and nimble research infrastructure that will lead to more rapid translation of our work for the betterment of public health.", "doi": "10.1158/1055-9965.EPI-20-0606", "pmid": "32371551", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "1055-9965.EPI-20-0606"}, {"db": "pmc", "key": "PMC7357669"}, {"db": "mid", "key": "NIHMS1605601"}], "notes": [], "created": "2020-11-30T09:10:08.022Z", "modified": "2020-11-30T09:10:08.046Z"}, {"entity": "publication", "iuid": "e0e15dfc412146968881757d0e0c0e1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e0e15dfc412146968881757d0e0c0e1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e0e15dfc412146968881757d0e0c0e1d"}}, "title": "Structure-based drug designing and immunoinformatics approach for SARS-CoV-2.", "authors": [{"family": "Panda", "given": "Pritam Kumar", "initials": "PK"}, {"family": "Arul", "given": "Murugan Natarajan", "initials": "MN"}, {"family": "Patel", "given": "Paritosh", "initials": "P"}, {"family": "Verma", "given": "Suresh K", "initials": "SK"}, {"family": "Luo", "given": "Wei", "initials": "W"}, {"family": "Rubahn", "given": "Horst-G\u00fcnter", "initials": "H"}, {"family": "Mishra", "given": "Yogendra Kumar", "initials": "YK"}, {"family": "Suar", "given": "Mrutyunjay", "initials": "M"}, {"family": "Ahuja", "given": "Rajeev", "initials": "R"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Sci Adv", "issn": "2375-2548", "issn-l": "2375-2548", "volume": "6", "issue": "28", "pages": "eabb8097"}, "abstract": "The prevalence of respiratory illness caused by the novel SARS-CoV-2 virus associated with multiple organ failures is spreading rapidly because of its contagious human-to-human transmission and inadequate globalhealth care systems. Pharmaceutical repurposing, an effective drug development technique using existing drugs, could shorten development time and reduce costs compared to those of de novo drug discovery. We carried out virtual screening of antiviral compounds targeting the spike glycoprotein (S), main protease (M pro), and the SARS-CoV-2 receptor binding domain (RBD)-angiotensin-converting enzyme 2 (ACE2) complex of SARS-CoV-2. PC786, an antiviral polymerase inhibitor, showed enhanced binding affinity to all the targets. Furthermore, the postfusion conformation of the trimeric S protein RBD with ACE2 revealed conformational changes associated with PC786 drug binding. Exploiting immunoinformatics to identify T cell and B cell epitopes could guide future experimental studies with a higher probability of discovering appropriate vaccine candidates with fewer experiments and higher reliability.", "doi": "10.1126/sciadv.abb8097", "pmid": "32691011", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Imaging": null}, "xrefs": [{"db": "pii", "key": "abb8097"}, {"db": "pmc", "key": "PMC7319274"}], "notes": [], "created": "2020-11-22T09:29:59.106Z", "modified": "2021-02-26T08:45:36.642Z"}, {"entity": "publication", "iuid": "0c693dbf11714aedb01adc0574874d49", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c693dbf11714aedb01adc0574874d49.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c693dbf11714aedb01adc0574874d49"}}, "title": "Severe maternal morbidity and mortality associated with COVID-19: The risk should not be downplayed.", "authors": [{"family": "Westgren", "given": "Magnus", "initials": "M"}, {"family": "Pettersson", "given": "Karin", "initials": "K"}, {"family": "Hagberg", "given": "Henrik", "initials": "H"}, {"family": "Acharya", "given": "Ganesh", "initials": "G"}], "type": "editorial", "published": "2020-07-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "7", "pages": "815-816", "issn-l": "0001-6349"}, "abstract": "Editorial", "doi": "10.1111/aogs.13900", "pmid": "32386440", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7273078"}], "notes": [], "created": "2020-11-25T07:50:33.073Z", "modified": "2020-12-10T07:44:28.141Z"}, {"entity": "publication", "iuid": "50ccecd135cf4a93bfc0e8d922c54278", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50ccecd135cf4a93bfc0e8d922c54278.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50ccecd135cf4a93bfc0e8d922c54278"}}, "title": "Rapid risk assessment from ECDC: Resurgence of reported cases of COVID-19 in the EU/EEA, the UK and EU candidate and potential candidate countries.", "authors": [{"family": "Eurosurveillance editorial team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "26", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.26.2007021", "pmid": "32643600", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7346365"}], "notes": [], "created": "2020-12-08T14:30:09.784Z", "modified": "2020-12-08T14:30:19.350Z"}, {"entity": "publication", "iuid": "5885b52cf6834f5dab52e3606ffac54e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5885b52cf6834f5dab52e3606ffac54e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5885b52cf6834f5dab52e3606ffac54e"}}, "title": "Public Health Agency of Sweden's Brief Report: Pregnant and postpartum women with severe acute respiratory syndrome coronavirus 2 infection in intensive care in Sweden.", "authors": [{"family": "Collin", "given": "Julius", "initials": "J"}, {"family": "Bystr\u00f6m", "given": "Emma", "initials": "E"}, {"family": "Carnahan", "given": "AnnaSara", "initials": "A"}, {"family": "Ahrne", "given": "Malin", "initials": "M"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "7", "pages": "819-822", "issn-l": "0001-6349"}, "abstract": "The Public Health Agency of Sweden has analyzed how many pregnant and postpartum women with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been treated in intensive care units (ICU) in Sweden between 19 March and 20 April 2020 compared with non-pregnant women of similar age. Cases were identified in a special reporting module within the Swedish Intensive Care Registry (SIR). Fifty-three women aged 20-45 years with SARS-CoV-2 were reported in SIR, and 13 of these women were either pregnant or postpartum (<1 week). The results indicate that the risk of being admitted to ICU may be higher in pregnant and postpartum women with laboratory-confirmed SARS-CoV-2 in Sweden, compared with non-pregnant women of similar age.", "doi": "10.1111/aogs.13901", "pmid": "32386441", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7273089"}], "notes": [], "created": "2020-12-10T07:58:07.980Z", "modified": "2021-02-26T08:45:48.195Z"}, {"entity": "publication", "iuid": "50c6a161919c4123b26f46a4f9663d4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50c6a161919c4123b26f46a4f9663d4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50c6a161919c4123b26f46a4f9663d4d"}}, "title": "Perspective: COVID-19, implications of nasal diseases and consequences for their management.", "authors": [{"family": "Jian", "given": "Li", "initials": "L"}, {"family": "Yi", "given": "Wei", "initials": "W"}, {"family": "Zhang", "given": "Nan", "initials": "N"}, {"family": "Wen", "given": "Weiping", "initials": "W"}, {"family": "Krysko", "given": "Olga", "initials": "O"}, {"family": "Song", "given": "Woo-Jung", "initials": "W"}, {"family": "Bachert", "given": "Claus", "initials": "C"}], "type": "editorial", "published": "2020-07-00", "journal": {"title": "J Allergy Clin Immunol", "issn": "1097-6825", "volume": "146", "issue": "1", "pages": "67-69", "issn-l": "0091-6749"}, "abstract": "Editorial", "doi": "10.1016/j.jaci.2020.04.030", "pmid": "32360869", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0091-6749(20)30625-4"}, {"db": "pmc", "key": "PMC7252138"}], "notes": [], "created": "2020-11-25T07:19:54.341Z", "modified": "2020-12-10T07:24:26.859Z"}, {"entity": "publication", "iuid": "a64f9d7c657f4b8188082ecd258c7b56", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a64f9d7c657f4b8188082ecd258c7b56.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a64f9d7c657f4b8188082ecd258c7b56"}}, "title": "Our Experience of Trauma Management During Novel Coronovirus 2019 (COVID-19) Pandemic in a Busy Trauma Center in Southern Iran.", "authors": [{"family": "Akbarialiabad", "given": "Hossein", "initials": "H"}, {"family": "Abdolrahimzadeh Fard", "given": "Hossein", "initials": "H"}, {"family": "Abbasi", "given": "Hamid Reza", "initials": "HR"}, {"family": "Bolandparvaz", "given": "Shahram", "initials": "S"}, {"family": "Mohseni", "given": "Shahin", "initials": "S"}, {"family": "Mehrnous", "given": "Vahid", "initials": "V"}, {"family": "Saleh", "given": "Mina", "initials": "M"}, {"family": "Roushenas", "given": "Sima", "initials": "S"}, {"family": "Paydar", "given": "Shahram", "initials": "S"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Bull Emerg Trauma", "issn": "2322-2522", "volume": "8", "issue": "3", "pages": "199-201", "issn-l": null}, "abstract": "During the past few months, the novel coronavirus 2019 (COVID-19) pandemic has significantly affected medical service provision. In Iran, it has caused around 197,000 inflictions and 9200 deaths up to June 18, 2020. While many departments turned to telehealth in this era, the trauma service should provide non-stop in presence service to the trauma victims. Our trauma center is the largest in the southwest of Iran, with the mean annual admission of 18,500 polytrauma patients. In this center, we designed a safety protocol to mitigate the spread of disease and also have a more robust case finding system, especially among asymptomatic carriers who attend hospitals based on their trauma. In brief, all unstable patients were considered SARS-COV-2 positive and were directed toward the Specialized COVID-19 related ICU. For all stable patients, history, physical examination, CXR, and lab test (Complete Blood Count, Erythrocyte Sedimentation Rate, C-Reactive Protein) were ordered before entering the wards. If there was any suspicion of COVID-19, the stable patient was admitted to the COVID-19 specialized ward. Among all 1805 patients admitted during a ten weeks interval (from January 30, 2020, to April 14, 2020), 84 had a red flag and toward to COVID-19 related wards. Of those, 67 had positive PCR or evidence in CT in favor of the COOVID-19. Moreover, during regular workups, we found that 19 completely asymptomatic trauma victims had typical Chest CT scan findings of COVID-19.", "doi": "10.30476/BEAT.2020.87029", "pmid": "32944581", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7468226"}], "notes": [], "created": "2020-12-03T15:27:34.904Z", "modified": "2021-02-26T08:45:48.547Z"}, {"entity": "publication", "iuid": "021965c398864f9b8c7a42d09c6b08d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/021965c398864f9b8c7a42d09c6b08d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/021965c398864f9b8c7a42d09c6b08d0"}}, "title": "Oncology during the COVID-19 pandemic: challenges, dilemmas and the psychosocial impact on cancer patients.", "authors": [{"family": "Tsamakis", "given": "Konstantinos", "initials": "K"}, {"family": "Gavriatopoulou", "given": "Maria", "initials": "M"}, {"family": "Schizas", "given": "Dimitrios", "initials": "D"}, {"family": "Stravodimou", "given": "Athina", "initials": "A"}, {"family": "Mougkou", "given": "Aikaterini", "initials": "A"}, {"family": "Tsiptsios", "given": "Dimitrios", "initials": "D"}, {"family": "Sioulas", "given": "Vasileios", "initials": "V"}, {"family": "Spartalis", "given": "Eleftherios", "initials": "E"}, {"family": "Sioulas", "given": "Athanasios D", "initials": "AD"}, {"family": "Tsamakis", "given": "Charalampos", "initials": "C"}, {"family": "Charalampakis", "given": "Nikolaos", "initials": "N"}, {"family": "Mueller", "given": "Christoph", "initials": "C"}, {"family": "Arya", "given": "Donna", "initials": "D"}, {"family": "Zarogoulidis", "given": "Paul", "initials": "P"}, {"family": "Spandidos", "given": "Demetrios A", "initials": "DA"}, {"family": "Dimopoulos", "given": "Meletios A", "initials": "MA"}, {"family": "Papageorgiou", "given": "Charalabos", "initials": "C"}, {"family": "Rizos", "given": "Emmanouil", "initials": "E"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Oncol Lett", "issn": "1792-1074", "volume": "20", "issue": "1", "pages": "441-447", "issn-l": null}, "abstract": "COVID-19 has caused unprecedented societal turmoil, triggering a rapid, still ongoing, transformation of healthcare provision on a global level. In this new landscape, it is highly important to acknowledge the challenges this pandemic poses on the care of the particularly vulnerable cancer patients and the subsequent psychosocial impact on them. We have outlined our clinical experience in managing patients with gastrointestinal, hematological, gynaecological, dermatological, neurological, thyroid, lung and paediatric cancers in the COVID-19 era and have reviewed the emerging literature around barriers to care of oncology patients and how this crisis affects them. Moreover, evolving treatment strategies and novel ways of addressing the needs of oncology patients in the new context of the pandemic are discussed.", "doi": "10.3892/ol.2020.11599", "pmid": "32565968", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "OL-0-0-11599"}, {"db": "pmc", "key": "PMC7285823"}], "notes": [], "created": "2020-11-26T12:16:52.516Z", "modified": "2020-11-30T08:59:19.190Z"}, {"entity": "publication", "iuid": "e8b6bd1ad99e460ca94575c9f0f8a8bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e8b6bd1ad99e460ca94575c9f0f8a8bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e8b6bd1ad99e460ca94575c9f0f8a8bd"}}, "title": "Obstetric and intensive-care strategies in a high-risk pregnancy with critical respiratory failure due to COVID-19: A case report.", "authors": [{"family": "Kolkova", "given": "Zuzana", "initials": "Z"}, {"family": "Bjurstr\u00f6m", "given": "Martin F", "initials": "MF"}, {"family": "L\u00e4nsberg", "given": "John-Kalle", "initials": "JK"}, {"family": "Svedas", "given": "Eimantas", "initials": "E"}, {"family": "Hamer", "given": "Maria Andrada", "initials": "MA"}, {"family": "Hansson", "given": "Stefan R", "initials": "SR"}, {"family": "Herbst", "given": "Andreas", "initials": "A"}, {"family": "Zaigham", "given": "Mehreen", "initials": "M"}], "type": "case reports", "published": "2020-07-00", "journal": {"title": "Case Rep Womens Health", "issn": "2214-9112", "volume": "27", "issue": null, "pages": "e00240", "issn-l": null}, "abstract": "With the disease burden increasing daily, there is a lack of evidence regarding the impact of COVID-19 in pregnancy. Healthy pregnant women are still not regarded as a susceptible group despite physiological changes that make pregnant women more vulnerable to severe infection. However, high-risk pregnancies may be associated with severe COVID-19 disease with respiratory failure, as outlined in this report. We discuss the importance of timely delivery and antenatal steroid administration in a critically ill patient.\n\nA 27-year-old pregnant woman (gravida 2, para 1) with type I diabetes, morbid obesity, hypothyroidism and a previous Caesarean section presented with critical respiratory failure secondary to COVID-19 at 32 weeks of gestation. A preterm emergency Caesarean section was performed, after steroid treatment for foetal lung maturation. The patient benefited from prone positioning; however, transient acute renal injury, rhabdomyolysis and sepsis led to prolonged intensive care and mechanical ventilation for 30 days. The baby had an uncomplicated recovery.\n\nCOVID-19 infection in high-risk pregnancies may result in severe maternal and neonatal outcomes such as critical respiratory failure requiring mechanical ventilation and premature termination of the pregnancy. Antenatal steroids may be of benefit for foetal lung maturation but should not delay delivery in severe cases.", "doi": "10.1016/j.crwh.2020.e00240", "pmid": "32714844", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2214-9112(20)30070-9"}, {"db": "pii", "key": "e00240"}, {"db": "pmc", "key": "PMC7340590"}], "notes": [], "created": "2020-12-07T16:13:01.929Z", "modified": "2021-02-26T08:45:48.823Z"}, {"entity": "publication", "iuid": "54f00ae9073c40afbf775f85fbaa23ac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54f00ae9073c40afbf775f85fbaa23ac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54f00ae9073c40afbf775f85fbaa23ac"}}, "title": "Multimodality Cardiovascular Imaging in the Midst of the COVID-19 Pandemic: Ramping Up Safely to a New Normal.", "authors": [{"family": "Zoghbi", "given": "William A", "initials": "WA"}, {"family": "DiCarli", "given": "Marcelo F", "initials": "MF"}, {"family": "Blankstein", "given": "Ron", "initials": "R"}, {"family": "Choi", "given": "Andrew D", "initials": "AD"}, {"family": "Dilsizian", "given": "Vasken", "initials": "V"}, {"family": "Flachskampf", "given": "Frank A", "initials": "FA"}, {"family": "Geske", "given": "Jeffrey B", "initials": "JB"}, {"family": "Grayburn", "given": "Paul A", "initials": "PA"}, {"family": "Jaffer", "given": "Farouc A", "initials": "FA"}, {"family": "Kwong", "given": "Raymond Y", "initials": "RY"}, {"family": "Leipsic", "given": "Jonathan A", "initials": "JA"}, {"family": "Marwick", "given": "Thomas H", "initials": "TH"}, {"family": "Nagel", "given": "Eike", "initials": "E"}, {"family": "Nieman", "given": "Koen", "initials": "K"}, {"family": "Raman", "given": "Subha V", "initials": "SV"}, {"family": "Salerno", "given": "Michael", "initials": "M"}, {"family": "Sengupta", "given": "Partho P", "initials": "PP"}, {"family": "Shaw", "given": "Leslee J", "initials": "LJ"}, {"family": "Chandrashekhar", "given": "Y S", "initials": "YS"}, {"family": "ACC Imaging Council", "given": "", "initials": ""}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "JACC Cardiovasc Imaging", "issn": "1876-7591", "volume": "13", "issue": "7", "pages": "1615-1626", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jcmg.2020.06.001", "pmid": "32646721", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1936-878X(20)30474-5"}, {"db": "pmc", "key": "PMC7290215"}], "notes": [], "created": "2020-11-30T08:51:25.555Z", "modified": "2020-11-30T08:51:25.580Z"}, {"entity": "publication", "iuid": "5fa587f8610347dca914e98d020b66eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5fa587f8610347dca914e98d020b66eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5fa587f8610347dca914e98d020b66eb"}}, "title": "Multidisciplinary research priorities for the COVID-19 pandemic - Authors' reply.", "authors": [{"family": "O'Connor", "given": "Rory C", "initials": "RC"}, {"family": "Hotopf", "given": "Matthew", "initials": "M"}, {"family": "Worthman", "given": "Carol M", "initials": "CM"}, {"family": "Perry", "given": "V Hugh", "initials": "VH"}, {"family": "Tracey", "given": "Irene", "initials": "I"}, {"family": "Wessely", "given": "Simon", "initials": "S"}, {"family": "Arseneault", "given": "Louise", "initials": "L"}, {"family": "Ballard", "given": "Clive", "initials": "C"}, {"family": "Christensen", "given": "Helen", "initials": "H"}, {"family": "Silver", "given": "Roxane Cohen", "initials": "RC"}, {"family": "Ford", "given": "Tamsin", "initials": "T"}, {"family": "John", "given": "Ann", "initials": "A"}, {"family": "Kabir", "given": "Thomas", "initials": "T"}, {"family": "King", "given": "Kate", "initials": "K"}, {"family": "Simpson", "given": "Alan", "initials": "A"}, {"family": "Madan", "given": "Ira", "initials": "I"}, {"family": "Cowan", "given": "Katherine", "initials": "K"}, {"family": "Bullmore", "given": "Ed", "initials": "E"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}], "type": "letter", "published": "2020-07-00", "journal": {"title": "Lancet Psychiatry", "issn": "2215-0374", "volume": "7", "issue": "7", "pages": "e44-e45", "issn-l": "2215-0366"}, "abstract": null, "doi": "10.1016/S2215-0366(20)30247-9", "pmid": "32563319", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2215-0366(20)30247-9"}, {"db": "pmc", "key": "PMC7302786"}], "notes": [], "created": "2020-11-19T19:34:04.325Z", "modified": "2020-12-08T16:42:41.940Z"}, {"entity": "publication", "iuid": "7ec0b821c62c47adb1d094adfc266824", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7ec0b821c62c47adb1d094adfc266824.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7ec0b821c62c47adb1d094adfc266824"}}, "title": "Monoclonal antibodies for the S2 subunit of spike of SARS-CoV-1 cross-react with the newly-emerged SARS-CoV-2.", "authors": [{"family": "Zheng", "given": "Zhiqiang", "initials": "Z"}, {"family": "Monteil", "given": "Vanessa Marthe", "initials": "VM"}, {"family": "Maurer-Stroh", "given": "Sebastian", "initials": "S"}, {"family": "Yew", "given": "Chow Wenn", "initials": "CW"}, {"family": "Leong", "given": "Carol", "initials": "C"}, {"family": "Mohd-Ismail", "given": "Nur Khairiah", "initials": "NK"}, {"family": "Cheyyatraivendran Arularasu", "given": "Suganya", "initials": "S"}, {"family": "Chow", "given": "Vincent Tak Kwong", "initials": "VTK"}, {"family": "Lin", "given": "Raymond Tzer Pin", "initials": "RTP"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Hong", "given": "Wanjin", "initials": "W"}, {"family": "Tan", "given": "Yee-Joo", "initials": "YJ"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "28", "issn-l": null}, "abstract": "BackgroundA novel coronavirus, SARS-CoV-2, which emerged at the end of 2019 and causes COVID-19, has resulted in worldwide human infections. While genetically distinct, SARS-CoV-1, the aetiological agent responsible for an outbreak of severe acute respiratory syndrome (SARS) in 2002-2003, utilises the same host cell receptor as SARS-CoV-2 for entry: angiotensin-converting enzyme 2 (ACE2). Parts of the SARS-CoV-1 spike glycoprotein (S protein), which interacts with ACE2, appear conserved in SARS-CoV-2.AimThe cross-reactivity with SARS-CoV-2 of monoclonal antibodies (mAbs) previously generated against the S protein of SARS-CoV-1 was assessed.MethodsThe SARS-CoV-2 S protein sequence was aligned to those of SARS-CoV-1, Middle East respiratory syndrome (MERS) and common-cold coronaviruses. Abilities of mAbs generated against SARS-CoV-1 S protein to bind SARS-CoV-2 or its S protein were tested with SARS-CoV-2 infected cells as well as cells expressing either the full length protein or a fragment of its S2 subunit. Quantitative ELISA was also performed to compare binding of mAbs to recombinant S protein.ResultsAn immunogenic domain in the S2 subunit of SARS-CoV-1 S protein is highly conserved in SARS-CoV-2 but not in MERS and human common-cold coronaviruses. Four murine mAbs raised against this immunogenic fragment could recognise SARS-CoV-2 S protein expressed in mammalian cell lines. In particular, mAb 1A9 was demonstrated to detect S protein in SARS-CoV-2-infected cells and is suitable for use in a sandwich ELISA format.ConclusionThe cross-reactive mAbs may serve as useful tools for SARS-CoV-2 research and for the development of diagnostic assays for COVID-19.", "doi": "10.2807/1560-7917.ES.2020.25.28.2000291", "pmid": "32700671", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Imaging": null}, "xrefs": [{"db": "pmc", "key": "PMC7376845"}], "notes": [], "created": "2020-12-07T16:22:09.955Z", "modified": "2021-02-26T08:45:36.612Z"}, {"entity": "publication", "iuid": "180b7ff648b8487f9227b1bee6cb8526", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/180b7ff648b8487f9227b1bee6cb8526.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/180b7ff648b8487f9227b1bee6cb8526"}}, "title": "Mobile Health Technology for Enhancing the COVID-19 Response in Africa: A Potential Game Changer?", "authors": [{"family": "Nachega", "given": "Jean B", "initials": "JB"}, {"family": "Leisegang", "given": "Rory", "initials": "R"}, {"family": "Kallay", "given": "Oscar", "initials": "O"}, {"family": "Mills", "given": "Edward J", "initials": "EJ"}, {"family": "Zumla", "given": "Alimuddin", "initials": "A"}, {"family": "Lester", "given": "Richard T", "initials": "RT"}], "type": "editorial", "published": "2020-07-00", "journal": {"title": "Am J Trop Med Hyg", "issn": "1476-1645", "volume": "103", "issue": "1", "pages": "3-5", "issn-l": "0002-9637"}, "abstract": null, "doi": "10.4269/ajtmh.20-0506", "pmid": "32476643", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7356462"}], "notes": [], "created": "2020-11-19T14:52:44.187Z", "modified": "2020-12-09T10:56:27.358Z"}, {"entity": "publication", "iuid": "da8d6c9ff2114a42b5988ab677cadb37", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/da8d6c9ff2114a42b5988ab677cadb37.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/da8d6c9ff2114a42b5988ab677cadb37"}}, "title": "Maternal mental health in the time of the COVID-19 pandemic.", "authors": [{"family": "Thapa", "given": "Suraj B", "initials": "SB"}, {"family": "Mainali", "given": "Anustha", "initials": "A"}, {"family": "Schwank", "given": "Simone E", "initials": "SE"}, {"family": "Acharya", "given": "Ganesh", "initials": "G"}], "type": "editorial", "published": "2020-07-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "7", "pages": "817-818", "issn-l": "0001-6349"}, "abstract": null, "doi": "10.1111/aogs.13894", "pmid": "32374420", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7267371"}], "notes": [], "created": "2020-12-10T07:33:05.949Z", "modified": "2020-12-10T07:35:13.106Z"}, {"entity": "publication", "iuid": "2151e438279c4482b86b2b0c8239b4a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2151e438279c4482b86b2b0c8239b4a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2151e438279c4482b86b2b0c8239b4a4"}}, "title": "Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies.", "authors": [{"family": "Zaigham", "given": "Mehreen", "initials": "M"}, {"family": "Andersson", "given": "Ola", "initials": "O"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "7", "pages": "823-829", "issn-l": "0001-6349"}, "abstract": "The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has exposed vulnerable populations to an unprecedented global health crisis. The knowledge gained from previous human coronavirus outbreaks suggests that pregnant women and their fetuses are particularly susceptible to poor outcomes. The objective of this study was to summarize the clinical manifestations and maternal and perinatal outcomes of COVID-19 during pregnancy.\n\nWe searched databases for all case reports and series from 12 February to 4 April 2020. Multiple terms and combinations were used including COVID-19, pregnancy, maternal mortality, maternal morbidity, complications, clinical manifestations, neonatal morbidity, intrauterine fetal death, neonatal mortality and SARS-CoV-2. Eligibility criteria included peer-reviewed publications written in English or Chinese and quantitative real-time polymerase chain reaction (PCR) or dual fluorescence PCR-confirmed SARS-CoV-2 infection. Unpublished reports, unspecified date and location of the study or suspicion of duplicate reporting, cases with suspected COVID-19 that were not confirmed by a laboratory test, and unreported maternal or perinatal outcomes were excluded. Data on clinical manifestations, maternal and perinatal outcomes including vertical transmission were extracted and analyzed.\n\nEighteen articles reporting data from 108 pregnancies between 8 December 2019 and 1 April 2020 were included in the current study. Most reports described women presenting in the third trimester with fever (68%) and coughing (34%). Lymphocytopenia (59%) with elevated C-reactive protein (70%) was observed and 91% of the women were delivered by cesarean section. Three maternal intensive care unit admissions were noted but no maternal deaths. One neonatal death and one intrauterine death were also reported.\n\nAlthough the majority of mothers were discharged without any major complications, severe maternal morbidity as a result of COVID-19 and perinatal deaths were reported. Vertical transmission of the COVID-19 could not be ruled out. Careful monitoring of pregnancies with COVID-19 and measures to prevent neonatal infection are warranted.", "doi": "10.1111/aogs.13867", "pmid": "32259279", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7262097"}], "notes": [], "created": "2020-11-30T15:55:39.008Z", "modified": "2020-11-30T15:55:39.021Z"}, {"entity": "publication", "iuid": "96eef9ada9a44102903b21f3f0ac210b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/96eef9ada9a44102903b21f3f0ac210b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/96eef9ada9a44102903b21f3f0ac210b"}}, "title": "Management of a COVID-19 outbreak in a hotel in Tenerife, Spain.", "authors": [{"family": "Hoefer", "given": "Andreas", "initials": "A"}, {"family": "Pampaka", "given": "Despina", "initials": "D"}, {"family": "Rivas Wagner", "given": "Eva", "initials": "E"}, {"family": "Alem\u00e1n Herrera", "given": "Araceli", "initials": "A"}, {"family": "Garc\u00eda-Ramos Alonso", "given": "Eduardo", "initials": "E"}, {"family": "L\u00f3pez-Perea", "given": "Noem\u00ed", "initials": "N"}, {"family": "Cano Portero", "given": "Rosa", "initials": "R"}, {"family": "Herrera-Le\u00f3n", "given": "Laura", "initials": "L"}, {"family": "Herrera-Le\u00f3n", "given": "Silvia", "initials": "S"}, {"family": "N\u00fa\u00f1ez Gallo", "given": "Domingo", "initials": "D"}], "type": "case reports", "published": "2020-07-00", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": "96", "issue": null, "pages": "384-386"}, "abstract": "Since the first accounts of SARS-CoV-2, authorities have encountered numerous unprecedented situations threatening public health. This rapid communication addresses events that led to the quarantining of a hotel in Tenerife, Spain and the effectiveness of the rapidly implemented control measures. In total, eight cases have been associated with the hotel. Due to the international nature of the guests, had these timely precautions not been in place, a multinational cluster might have formed.", "doi": "10.1016/j.ijid.2020.05.047", "pmid": "32425635", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(20)30354-4"}, {"db": "pmc", "key": "PMC7231486"}], "notes": [], "created": "2020-12-09T11:43:15.406Z", "modified": "2020-12-09T11:43:54.389Z"}, {"entity": "publication", "iuid": "b8f85e06a4644e5c9870905c0125d822", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8f85e06a4644e5c9870905c0125d822.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8f85e06a4644e5c9870905c0125d822"}}, "title": "International expert consensus statement regarding radiotherapy treatment options for rectal cancer during the COVID 19 pandemic.", "authors": [{"family": "Marijnen", "given": "C A M", "initials": "CAM"}, {"family": "Peters", "given": "F P", "initials": "FP"}, {"family": "R\u00f6del", "given": "C", "initials": "C"}, {"family": "Bujko", "given": "K", "initials": "K"}, {"family": "Haustermans", "given": "K", "initials": "K"}, {"family": "Fokas", "given": "E", "initials": "E"}, {"family": "Glynne-Jones", "given": "R", "initials": "R"}, {"family": "Valentini", "given": "V", "initials": "V"}, {"family": "Spindler", "given": "K-L G", "initials": "KG"}, {"family": "Guren", "given": "M G", "initials": "MG"}, {"family": "Maingon", "given": "Philippe", "initials": "P"}, {"family": "Calvo", "given": "F A", "initials": "FA"}, {"family": "Pares", "given": "O", "initials": "O"}, {"family": "Glimelius", "given": "B", "initials": "B"}, {"family": "Sebag-Montefiore", "given": "D", "initials": "D"}], "type": "letter", "published": "2020-07-00", "journal": {"title": "Radiother Oncol", "issn": "1879-0887", "volume": "148", "issue": null, "pages": "213-215", "issn-l": "0167-8140"}, "abstract": null, "doi": "10.1016/j.radonc.2020.03.039", "pmid": "32342861", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0167-8140(20)30173-0"}, {"db": "pmc", "key": "PMC7194592"}], "notes": [], "created": "2020-12-10T07:14:52.505Z", "modified": "2020-12-10T07:16:00.513Z"}, {"entity": "publication", "iuid": "ec472b86cef64d62be6ea9374a1da38d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec472b86cef64d62be6ea9374a1da38d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec472b86cef64d62be6ea9374a1da38d"}}, "title": "International Organization for the Study of IBD Recommendations for Surgery in Patients With IBD During the Coronavirus Disease 2019 Pandemic.", "authors": [{"family": "Remzi", "given": "Feza H", "initials": "FH"}, {"family": "Panis", "given": "Yves", "initials": "Y"}, {"family": "Spinelli", "given": "Antonino", "initials": "A"}, {"family": "Kotze", "given": "Paulo G", "initials": "PG"}, {"family": "Mantzaris", "given": "Gerassimos", "initials": "G"}, {"family": "S\u00f6derholm", "given": "Johan D", "initials": "JD"}, {"family": "d'Hoore", "given": "Andr\u00e9", "initials": "A"}, {"family": "Bemelman", "given": "Willem A", "initials": "WA"}, {"family": "Yamamoto", "given": "Takayuki", "initials": "T"}, {"family": "Pemberton", "given": "John H", "initials": "JH"}, {"family": "Tiret", "given": "Emmanuel", "initials": "E"}, {"family": "\u00d8resland", "given": "Tom", "initials": "T"}, {"family": "Fleshner", "given": "Phillip", "initials": "P"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Dis Colon Rectum", "issn": "1530-0358", "volume": "63", "issue": "7", "pages": "870-873", "issn-l": null}, "abstract": null, "doi": "10.1097/DCR.0000000000001718", "pmid": "32355056", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-10T07:16:56.833Z", "modified": "2020-12-10T07:17:39.381Z"}, {"entity": "publication", "iuid": "0179eb6762e54a4ca86be4f91c1ebc5d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0179eb6762e54a4ca86be4f91c1ebc5d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0179eb6762e54a4ca86be4f91c1ebc5d"}}, "title": "Impact of COVID-19 on Prostate Cancer Management: Guidelines for Urologists.", "authors": [{"family": "Dovey", "given": "Zachary", "initials": "Z"}, {"family": "Mohamed", "given": "Nihal", "initials": "N"}, {"family": "Gharib", "given": "Yasmine", "initials": "Y"}, {"family": "Ratnani", "given": "Parita", "initials": "P"}, {"family": "Hammouda", "given": "Nada", "initials": "N"}, {"family": "Nair", "given": "Sujit S", "initials": "SS"}, {"family": "Chakravarty", "given": "Dimple", "initials": "D"}, {"family": "Sobotka", "given": "Stanislaw", "initials": "S"}, {"family": "Lantz", "given": "Anna", "initials": "A"}, {"family": "Wiklund", "given": "Peter", "initials": "P"}, {"family": "Kyprianou", "given": "Natasha", "initials": "N"}, {"family": "Tewari", "given": "Ash", "initials": "A"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Eur Urol Open Sci", "issn": "2666-1683", "volume": "20", "pages": "1-11", "issn-l": null}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has resulted in a global health emergency, the like of which has never been seen before. Prostate cancer (PCa) services across the globe have been on hold due to changing medical and surgical priorities. There is also epidemiological evidence that PCa patients have increased incidence and mortality from SARS-CoV-2 infection due to gender differences, age, and higher propensity for risk factors (eg, respiratory disease, obesity, hypertension, and smoking status).\n\nTo contribute to the emerging body of knowledge on the risks of SARS-CoV-2 infection to PCa patients and, in the face of PCa treatment delays, provide evidence-based recommendations for ongoing management of specific PCa patient groups.\n\nA literature search was performed using all sources (MEDLINE, EMBASE, ScienceDirect, Cochrane Libraries, and Web of Science) as well as the media to harness emerging data on the SARS-CoV-2 pandemic and its influence on PCa. Eligibility criteria were originality of data and relevance to PCa management. The authors note that during these unprecedented times, retrospective data are constantly being updated from multiple sources globally.\n\nA total of 72 articles and data sources were found initially. Owing to repetition, lack of originality, or nonrelevance, six articles were rejected, leaving 23 retrospective studies, seven basic science research articles, 15 societal and journal guidelines, and 21 epidemiological data sources, from countries at different stages of SARS-CoV-2 pandemic. These were analyzed qualitatively to produce evidence-based guidelines for the management of PCa patients at different stages of the patient journey, with strategies to reduce the risk of viral spread.\n\nPCa patients may have an increased risk of SARS-CoV-2 infection as well as morbidity and mortality if infected. Once appropriately triaged, and to reduce viral spread, PCa patients can have surveillance by telemedicine, and institute lifestyle changes and social quarantining measures. If risk stratification suggests that treatment should be planned, androgen deprivation therapy can be started, or potentially surgery or radiation therapy is possible on a case-by-case basis.\n\nProstate cancer patients can be followed up remotely until the severe acute respiratory syndrome coronavirus 2 pandemic resolves, but higher-risk cases may have treatment expedited to limit any negative impact on prostate cancer outcomes.", "doi": "10.1016/j.euros.2020.05.005", "pmid": "34173542", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2666-1683(20)35112-0"}, {"db": "pmc", "key": "PMC7296308"}], "notes": [], "created": "2021-06-28T18:10:08.713Z", "modified": "2021-06-28T18:10:08.739Z"}, {"entity": "publication", "iuid": "f696e692cb204174b59deef6989d8d6a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f696e692cb204174b59deef6989d8d6a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f696e692cb204174b59deef6989d8d6a"}}, "title": "Illegal Online Sexual Behavior During the COVID-19 Pandemic: A Call for Action Based on Experiences From the Ongoing Prevent It Research Study.", "authors": [{"family": "Parks", "given": "Allison", "initials": "A"}, {"family": "Sparre", "given": "Charlotte", "initials": "C"}, {"family": "S\u00f6derquist", "given": "Elin", "initials": "E"}, {"family": "Arver", "given": "Stefan", "initials": "S"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Kaldo", "given": "Viktor", "initials": "V"}, {"family": "G\u00f6rts-\u00d6berg", "given": "Katarina", "initials": "K"}, {"family": "Rahm", "given": "Christoffer", "initials": "C"}], "type": "letter", "published": "2020-07-00", "journal": {"title": "Arch Sex Behav", "issn": "1573-2800", "issn-l": "0004-0002", "volume": "49", "issue": "5", "pages": "1433-1435"}, "abstract": null, "doi": "10.1007/s10508-020-01750-7", "pmid": "32488645", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10508-020-01750-7"}, {"db": "pmc", "key": "PMC7266414"}], "notes": [], "created": "2020-11-25T09:30:06.115Z", "modified": "2020-12-11T12:58:18.631Z"}, {"entity": "publication", "iuid": "13ebcfe1236a492abaaf8d03a0b655b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13ebcfe1236a492abaaf8d03a0b655b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13ebcfe1236a492abaaf8d03a0b655b0"}}, "title": "Handling of allergen immunotherapy in the COVID-19 pandemic: An ARIA-EAACI statement.", "authors": [{"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Jutel", "given": "Marek", "initials": "M"}, {"family": "Akdis", "given": "Cezmi", "initials": "C"}, {"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Akdis", "given": "M\u00fcbeccel", "initials": "M"}, {"family": "Bachert", "given": "Claus", "initials": "C"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Ansotegui", "given": "Ignacio", "initials": "I"}, {"family": "Bedbrook", "given": "Anna", "initials": "A"}, {"family": "Bosnic-Anticevich", "given": "Sinthia", "initials": "S"}, {"family": "Canonica", "given": "Giorgio W", "initials": "GW"}, {"family": "Chivato", "given": "Tomas", "initials": "T"}, {"family": "Cruz", "given": "Alvaro A", "initials": "AA"}, {"family": "Czarlewski", "given": "Wienia", "initials": "W"}, {"family": "Del Giacco", "given": "Stefano", "initials": "S"}, {"family": "Du", "given": "Hui", "initials": "H"}, {"family": "Fonseca", "given": "Joao A", "initials": "JA"}, {"family": "Gao", "given": "Yadong", "initials": "Y"}, {"family": "Haahtela", "given": "Tari", "initials": "T"}, {"family": "Hoffmann-Sommergruber", "given": "Karin", "initials": "K"}, {"family": "Ivancevich", "given": "Juan-Carlos", "initials": "J"}, {"family": "Khaltaev", "given": "Nikolai", "initials": "N"}, {"family": "Knol", "given": "Edward F", "initials": "EF"}, {"family": "Kuna", "given": "Piotr", "initials": "P"}, {"family": "Larenas-Linnemann", "given": "Desiree", "initials": "D"}, {"family": "Melen", "given": "Erik", "initials": "E"}, {"family": "Mullol", "given": "Joaquim", "initials": "J"}, {"family": "Naclerio", "given": "Robert", "initials": "R"}, {"family": "Ohta", "given": "Ken", "initials": "K"}, {"family": "Okamoto", "given": "Yoshitaka", "initials": "Y"}, {"family": "O'Mahony", "given": "Liam", "initials": "L"}, {"family": "Onorato", "given": "Gabrielle L", "initials": "GL"}, {"family": "Papadopoulos", "given": "Nikos G", "initials": "NG"}, {"family": "Pawankar", "given": "Ruby", "initials": "R"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Samolinski", "given": "Boleslaw", "initials": "B"}, {"family": "Schwarze", "given": "Jurgen", "initials": "J"}, {"family": "Toppila-Salmi", "given": "Sanna", "initials": "S"}, {"family": "Shamji", "given": "Mohamed H", "initials": "MH"}, {"family": "Teresa Ventura", "given": "Maria", "initials": "M"}, {"family": "Valiulis", "given": "Arunas", "initials": "A"}, {"family": "Yorgancioglu", "given": "Arzu", "initials": "A"}, {"family": "Matricardi", "given": "Paolo", "initials": "P"}, {"family": "Zuberbier", "given": "Torsten", "initials": "T"}, {"family": "ARIA-MASK Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": "75", "issue": "7", "pages": "1546-1554", "issn-l": "0105-4538"}, "abstract": null, "doi": "10.1111/all.14336", "pmid": "32329930", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7264744"}], "notes": [], "created": "2020-11-23T11:47:55.525Z", "modified": "2020-11-23T11:48:33.320Z"}, {"entity": "publication", "iuid": "7156626f870e4e5987ce1779717d55b5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7156626f870e4e5987ce1779717d55b5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7156626f870e4e5987ce1779717d55b5"}}, "title": "Excess all-cause mortality during the COVID-19 pandemic in Europe - preliminary pooled estimates from the EuroMOMO network, March to April 2020.", "authors": [{"family": "Vestergaard", "given": "Lasse S", "initials": "LS"}, {"family": "Nielsen", "given": "Jens", "initials": "J"}, {"family": "Richter", "given": "Lukas", "initials": "L"}, {"family": "Schmid", "given": "Daniela", "initials": "D"}, {"family": "Bustos", "given": "Natalia", "initials": "N"}, {"family": "Braeye", "given": "Toon", "initials": "T"}, {"family": "Denissov", "given": "Gleb", "initials": "G"}, {"family": "Veideman", "given": "Tatjana", "initials": "T"}, {"family": "Luomala", "given": "Oskari", "initials": "O"}, {"family": "M\u00f6tt\u00f6nen", "given": "Teemu", "initials": "T"}, {"family": "Fouillet", "given": "Anne", "initials": "A"}, {"family": "Caserio-Sch\u00f6nemann", "given": "C\u00e9line", "initials": "C"}, {"family": "An der Heiden", "given": "Matthias", "initials": "M"}, {"family": "Uphoff", "given": "Helmut", "initials": "H"}, {"family": "Lytras", "given": "Theodore", "initials": "T"}, {"family": "Gkolfinopoulou", "given": "Kassiani", "initials": "K"}, {"family": "Paldy", "given": "Anna", "initials": "A"}, {"family": "Domegan", "given": "Lisa", "initials": "L"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}, {"family": "De' Donato", "given": "Francesca", "initials": "F"}, {"family": "Noccioli", "given": "Fiammetta", "initials": "F"}, {"family": "Hoffmann", "given": "Patrick", "initials": "P"}, {"family": "Velez", "given": "Telma", "initials": "T"}, {"family": "England", "given": "Kathleen", "initials": "K"}, {"family": "van Asten", "given": "Liselotte", "initials": "L"}, {"family": "White", "given": "Richard A", "initials": "RA"}, {"family": "T\u00f8nnessen", "given": "Ragnhild", "initials": "R"}, {"family": "da Silva", "given": "Susana P", "initials": "SP"}, {"family": "Rodrigues", "given": "Ana P", "initials": "AP"}, {"family": "Larrauri", "given": "Amparo", "initials": "A"}, {"family": "Delgado-Sanz", "given": "Concepci\u00f3n", "initials": "C"}, {"family": "Farah", "given": "Ahmed", "initials": "A"}, {"family": "Galanis", "given": "Ilias", "initials": "I"}, {"family": "Junker", "given": "Christoph", "initials": "C"}, {"family": "Perisa", "given": "Damir", "initials": "D"}, {"family": "Sinnathamby", "given": "Mary", "initials": "M"}, {"family": "Andrews", "given": "Nick", "initials": "N"}, {"family": "O'Doherty", "given": "Mark", "initials": "M"}, {"family": "Marquess", "given": "Diogo Fp", "initials": "DF"}, {"family": "Kennedy", "given": "Sharon", "initials": "S"}, {"family": "Olsen", "given": "Sonja J", "initials": "SJ"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "ECDC Public Health Emergency Team for COVID-19", "given": "", "initials": ""}, {"family": "Krause", "given": "Tyra G", "initials": "TG"}, {"family": "M\u00f8lbak", "given": "K\u00e5re", "initials": "K"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "26", "issn-l": null}, "abstract": "A remarkable excess mortality has coincided with the COVID-19 pandemic in Europe. We present preliminary pooled estimates of all-cause mortality for 24 European countries/federal states participating in the European monitoring of excess mortality for public health action (EuroMOMO) network, for the period March-April 2020. Excess mortality particularly affected \u2265 65 year olds (91% of all excess deaths), but also 45-64 (8%) and 15-44 year olds (1%). No excess mortality was observed in 0-14 year olds.", "doi": "10.2807/1560-7917.ES.2020.25.26.2001214", "pmid": "32643601", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7346364"}], "notes": [], "created": "2020-12-08T14:29:31.649Z", "modified": "2020-12-08T14:29:31.659Z"}, {"entity": "publication", "iuid": "edf06ad57a0542d6a1ecd42c8c6c3cc2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/edf06ad57a0542d6a1ecd42c8c6c3cc2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/edf06ad57a0542d6a1ecd42c8c6c3cc2"}}, "title": "European Society for Neurogastroenterology and Motility recommendations for conducting gastrointestinal motility and function testing in the recovery phase of the COVID-19 pandemic.", "authors": [{"family": "Tack", "given": "Jan", "initials": "J"}, {"family": "Vanuytsel", "given": "Tim", "initials": "T"}, {"family": "Serra", "given": "Jordi", "initials": "J"}, {"family": "Accarino", "given": "Anna", "initials": "A"}, {"family": "Stanghellini", "given": "Vincenzo", "initials": "V"}, {"family": "Barbara", "given": "Giovanni", "initials": "G"}, {"family": "ESNM Consensus Group, the Leuven Consensus Group, the Italian Consensus Group, the Spanish Consensus Group on function testing in the COVID-19 pandemic era", "given": "", "initials": ""}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Neurogastroenterol Motil", "issn": "1365-2982", "volume": "32", "issue": "7", "pages": "e13930", "issn-l": null}, "abstract": "During the peak of the COronaVIrus Disease 2019 (COVID-19) pandemic, care for patients with gastrointestinal motility and functional disorders was largely suspended. In the recovery phases of the pandemic, non-urgent medical care is resumed, but there is a lack of guidance for restarting and safely conducting motility and function testing. Breath tests and insertion of manometry and pH-monitoring probes carry a risk of SARS-CoV-2 spread through droplet formation.\n\nA panel of experts from the European Society for Neurogastroenterology and Motility (ESNM) evaluated emerging national and single-center recommendations to provide the best current evidence and a pragmatic approach to ensure the safe conduct of motility and function testing for both healthcare professionals and patients.\n\nAt a general level, this involves evaluation of the urgency of the procedure, evaluation of the infectious risk associated with the patient, the investigation and the healthcare professional(s) involved, provision of the test planning and test units, education and training of staff, and use of personnel protection equipment. Additional guidance is provided for specific procedures such as esophageal manometry, pH monitoring, and breath tests.\n\nThe ESNM guidelines provide pragmatic and appropriate guidance for the safe conduct of motility and function testing in the COVID-19 pandemic and early recovery phase.", "doi": "10.1111/nmo.13930", "pmid": "32525249", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7300574"}], "notes": [], "created": "2020-12-09T10:07:33.877Z", "modified": "2020-12-09T10:07:33.899Z"}, {"entity": "publication", "iuid": "8af419f2fae34df29919e6ee13faddcc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8af419f2fae34df29919e6ee13faddcc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8af419f2fae34df29919e6ee13faddcc"}}, "title": "European Association of Urology Guidelines Office Rapid Reaction Group: An Organisation-wide Collaborative Effort to Adapt the European Association of Urology Guidelines Recommendations to the Coronavirus Disease 2019 Era.", "authors": [{"family": "Ribal", "given": "Maria J", "initials": "MJ"}, {"family": "Cornford", "given": "Philip", "initials": "P"}, {"family": "Briganti", "given": "Alberto", "initials": "A"}, {"family": "Knoll", "given": "Thomas", "initials": "T"}, {"family": "Gravas", "given": "Stavros", "initials": "S"}, {"family": "Babjuk", "given": "Marek", "initials": "M"}, {"family": "Harding", "given": "Christopher", "initials": "C"}, {"family": "Breda", "given": "Alberto", "initials": "A"}, {"family": "Bex", "given": "Axel", "initials": "A"}, {"family": "GORRG Group", "given": "", "initials": ""}, {"family": "Rassweiler", "given": "Jens J", "initials": "JJ"}, {"family": "G\u00f6zen", "given": "Ali S", "initials": "AS"}, {"family": "Pini", "given": "Giovannalberto", "initials": "G"}, {"family": "Liatsikos", "given": "Evangelos", "initials": "E"}, {"family": "Giannarini", "given": "Gianluca", "initials": "G"}, {"family": "Mottrie", "given": "Alex", "initials": "A"}, {"family": "Subramaniam", "given": "Ramnath", "initials": "R"}, {"family": "Sofikitis", "given": "Nikolaos", "initials": "N"}, {"family": "Rocco", "given": "Bernardo M C", "initials": "BMC"}, {"family": "Xie", "given": "Li-Ping", "initials": "LP"}, {"family": "Witjes", "given": "J Alfred", "initials": "JA"}, {"family": "Mottet", "given": "Nicolas", "initials": "N"}, {"family": "Ljungberg", "given": "B\u00f6rje", "initials": "B"}, {"family": "Roupr\u00eat", "given": "Morgan", "initials": "M"}, {"family": "Laguna", "given": "Maria P", "initials": "MP"}, {"family": "Salonia", "given": "Andrea", "initials": "A"}, {"family": "Bonkat", "given": "Gernot", "initials": "G"}, {"family": "Blok", "given": "Bertil F M", "initials": "BFM"}, {"family": "T\u00fcrk", "given": "Christian", "initials": "C"}, {"family": "Radmayr", "given": "Christian", "initials": "C"}, {"family": "Kitrey", "given": "Noam D", "initials": "ND"}, {"family": "Engeler", "given": "Daniel S", "initials": "DS"}, {"family": "Lumen", "given": "Nicolaas", "initials": "N"}, {"family": "Hakenberg", "given": "Oliver W", "initials": "OW"}, {"family": "Watkin", "given": "Nick", "initials": "N"}, {"family": "Hamid", "given": "Rizwan", "initials": "R"}, {"family": "Olsburgh", "given": "Jonathon", "initials": "J"}, {"family": "Darraugh", "given": "Julie", "initials": "J"}, {"family": "Shepherd", "given": "Robert", "initials": "R"}, {"family": "Smith", "given": "Emma-Jane", "initials": "EJ"}, {"family": "Chapple", "given": "Christopher R", "initials": "CR"}, {"family": "Stenzl", "given": "Arnulf", "initials": "A"}, {"family": "Van Poppel", "given": "Hendrik", "initials": "H"}, {"family": "Wirth", "given": "Manfred", "initials": "M"}, {"family": "S\u00f8nksen", "given": "Jens", "initials": "J"}, {"family": "N'Dow", "given": "James", "initials": "J"}, {"family": "EAU Section Offices and the EAU Guidelines Panels", "given": "", "initials": ""}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Eur Urol", "issn": "1873-7560", "volume": "78", "issue": "1", "pages": "21-28", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic is unlike anything seen before by modern science-based medicine. Health systems across the world are struggling to manage it. Added to this struggle are the effects of social confinement and isolation. This brings into question whether the latest guidelines are relevant in this crisis. We aim to support urologists in this difficult situation by providing tools that can facilitate decision making, and to minimise the impact and risks for both patients and health professionals delivering urological care, whenever possible. We hope that the revised recommendations will assist urologist surgeons across the globe to guide the management of urological conditions during the current COVID-19 pandemic.", "doi": "10.1016/j.eururo.2020.04.056", "pmid": "32376137", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0302-2838(20)30324-9"}, {"db": "pmc", "key": "PMC7183974"}], "notes": [], "created": "2020-12-10T07:36:06.469Z", "modified": "2020-12-10T07:36:06.491Z"}, {"entity": "publication", "iuid": "72356b6b1430403297ae0fd5a1af6e57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/72356b6b1430403297ae0fd5a1af6e57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/72356b6b1430403297ae0fd5a1af6e57"}}, "title": "Ethical triage during the COVID-19 pandemic: a toolkit for neurosurgical resource allocation.", "authors": [{"family": "Hulsbergen", "given": "Alexander F C", "initials": "AFC"}, {"family": "Eijkholt", "given": "Marleen M", "initials": "MM"}, {"family": "Balak", "given": "Naci", "initials": "N"}, {"family": "Brennum", "given": "Jannick", "initials": "J"}, {"family": "Bolger", "given": "Ciar\u00e1n", "initials": "C"}, {"family": "Bohrer", "given": "Anna-Margarete", "initials": "AM"}, {"family": "Feldman", "given": "Zeev", "initials": "Z"}, {"family": "Holsgrove", "given": "Daniel", "initials": "D"}, {"family": "Kitchen", "given": "Neil", "initials": "N"}, {"family": "Mathiesen", "given": "Tiit I", "initials": "TI"}, {"family": "Moojen", "given": "Wouter A", "initials": "WA"}, {"family": "Sampr\u00f3n", "given": "Nicol\u00e1s", "initials": "N"}, {"family": "Sames", "given": "Martin", "initials": "M"}, {"family": "Sandvik", "given": "Ulrika", "initials": "U"}, {"family": "Tisell", "given": "Magnus", "initials": "M"}, {"family": "Broekman", "given": "Marike L D", "initials": "MLD"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Acta Neurochir (Wien)", "issn": "0942-0940", "volume": "162", "issue": "7", "pages": "1485-1490", "issn-l": "0001-6268"}, "abstract": "The COVID-19 pandemic confronts healthcare workers, including neurosurgeons, with difficult choices regarding which patients to treat.\n\nIn order to assist ethical triage, this article gives an overview of the main considerations and ethical principles relevant when allocating resources in times of scarcity.\n\nWe discuss a framework employing four principles: prioritizing the worst off, maximizing benefits, treating patients equally, and promoting instrumental value. We furthermore discuss the role of age and comorbidity in triage and highlight some principles that may seem intuitive but should not form a basis for triage.\n\nThis overview is presented on behalf of the European Association of Neurosurgical Societies and can be used as a toolkit for neurosurgeons faced with ethical dilemmas when triaging patients in times of scarcity.", "doi": "10.1007/s00701-020-04375-w", "pmid": "32405671", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00701-020-04375-w"}, {"db": "pmc", "key": "PMC7220806"}], "notes": [], "created": "2020-11-25T08:04:50.218Z", "modified": "2020-11-30T09:07:55.694Z"}, {"entity": "publication", "iuid": "9b890af069da4a43983d613b4392d539", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b890af069da4a43983d613b4392d539.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b890af069da4a43983d613b4392d539"}}, "title": "Development of passive immunity against SARS-CoV-2 for management of immunodeficient patients-a perspective.", "authors": [{"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}], "type": "editorial", "published": "2020-07-00", "journal": {"title": "J Allergy Clin Immunol", "issn": "1097-6825", "issn-l": "0091-6749", "volume": "146", "issue": "1", "pages": "58-60"}, "abstract": "Editorial", "doi": "10.1016/j.jaci.2020.04.043", "pmid": "32413374", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: H2020": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0091-6749(20)30645-X"}, {"db": "pmc", "key": "PMC7215168"}], "notes": [], "created": "2020-11-25T08:26:38.332Z", "modified": "2021-02-26T08:45:48.511Z"}, {"entity": "publication", "iuid": "449b2397650449f9adffd907a41a9b9d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/449b2397650449f9adffd907a41a9b9d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/449b2397650449f9adffd907a41a9b9d"}}, "title": "COVID-19, chronic inflammatory respiratory diseases and eosinophils-Observations from reported clinical case series.", "authors": [{"family": "Jesenak", "given": "Milos", "initials": "M"}, {"family": "Banovcin", "given": "Peter", "initials": "P"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}], "type": "letter", "published": "2020-07-00", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": "75", "issue": "7", "pages": "1819-1822", "issn-l": "0105-4538"}, "abstract": null, "doi": "10.1111/all.14353", "pmid": "32369190", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-10T07:28:22.865Z", "modified": "2020-12-10T07:28:22.875Z"}, {"entity": "publication", "iuid": "8fc1af79aa724fc4bf30f7dd2e362aff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8fc1af79aa724fc4bf30f7dd2e362aff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8fc1af79aa724fc4bf30f7dd2e362aff"}}, "title": "COVID-19 in pregnancy with comorbidities: More liberal testing strategy is needed.", "authors": [{"family": "Gidl\u00f6f", "given": "Sebastian", "initials": "S"}, {"family": "Savchenko", "given": "Julia", "initials": "J"}, {"family": "Brune", "given": "Thomas", "initials": "T"}, {"family": "Josefsson", "given": "Hampus", "initials": "H"}], "type": "letter", "published": "2020-07-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "7", "pages": "948-949", "issn-l": "0001-6349"}, "abstract": null, "doi": "10.1111/aogs.13862", "pmid": "32249924", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-22T17:08:12.943Z", "modified": "2020-12-09T11:49:29.739Z"}, {"entity": "publication", "iuid": "f546322941284eb1a9ff39d0517dfcdd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f546322941284eb1a9ff39d0517dfcdd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f546322941284eb1a9ff39d0517dfcdd"}}, "title": "COVID-19 in People With Diabetes: Urgently Needed Lessons From Early Reports.", "authors": [{"family": "Riddle", "given": "Matthew C", "initials": "MC"}, {"family": "Buse", "given": "John B", "initials": "JB"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Knowler", "given": "William C", "initials": "WC"}, {"family": "Ratner", "given": "Robert E", "initials": "RE"}, {"family": "Selvin", "given": "Elizabeth", "initials": "E"}, {"family": "Wexler", "given": "Deborah J", "initials": "DJ"}, {"family": "Kahn", "given": "Steven E", "initials": "SE"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Diabetes Care", "issn": "1935-5548", "volume": "43", "issue": "7", "pages": "1378-1381", "issn-l": null}, "abstract": null, "doi": "10.2337/dci20-0024", "pmid": "32409505", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "dci20-0024"}, {"db": "pmc", "key": "PMC7305002"}], "notes": [], "created": "2020-12-10T08:50:46.407Z", "modified": "2020-12-10T08:50:46.431Z"}, {"entity": "publication", "iuid": "fb335d814dd541c58f67290f3969d67f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb335d814dd541c58f67290f3969d67f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb335d814dd541c58f67290f3969d67f"}}, "title": "COVID-19 Pandemic: Consensus guidelines for preferred practices in an aesthetic clinic.", "authors": [{"family": "Kapoor", "given": "Krishan M", "initials": "KM"}, {"family": "Chatrath", "given": "Vandana", "initials": "V"}, {"family": "Boxley", "given": "Sarah G", "initials": "SG"}, {"family": "Nurlin", "given": "Iman", "initials": "I"}, {"family": "Snozzi", "given": "Philippe", "initials": "P"}, {"family": "Demosthenous", "given": "Nestor", "initials": "N"}, {"family": "Belo", "given": "Victoria", "initials": "V"}, {"family": "Chan", "given": "Wai M", "initials": "WM"}, {"family": "Kanaris", "given": "Nicole", "initials": "N"}, {"family": "Kapoor", "given": "Puneet", "initials": "P"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Dermatol Ther", "issn": "1529-8019", "volume": "33", "issue": "4", "pages": "e13597", "issn-l": null}, "abstract": "Strict infection control measures in response to the current COVID-19 pandemic are expected to remain for an extended period. In aesthetic clinics, most procedures are provided on one to one basis by the physician or therapist. In such a scenario, guidelines detailing the infection control measures for aesthetic clinics are of particular importance. An online meeting of an international group of experts in the field of aesthetic medicine, with experience in administration of an aesthetic clinic, was convened. The meeting aimed to provide a set of consensus guidelines to protect clinic staff and patients from SARS-CoV-2 infection. Consensus guidelines for \"preferred practices\" were provided for scheduling of patients, patient evaluation and triaging, and for safety precautions about the different procedures. Procedures were categorized into low-risk, moderate risk, and high-risk based on the likelihood of transmission of SARS-CoV-2 virus from the patient to the treating physician or therapist. While not intended to be complete or exhaustive, these guidelines provide sound infection control measures for aesthetic practices. Since guidelines regarding safety measures and use of PPEs may vary from country to country, the local guidelines should also be followed to prevent COVID-19 infection in aesthetic clinics.", "doi": "10.1111/dth.13597", "pmid": "32415753", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7267045"}], "notes": [], "created": "2020-11-30T09:07:54.552Z", "modified": "2020-11-30T09:07:54.576Z"}, {"entity": "publication", "iuid": "18d87d9d720145059313eeaec0571d68", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18d87d9d720145059313eeaec0571d68.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18d87d9d720145059313eeaec0571d68"}}, "title": "Author Correction: Caring for patients with cancer in the COVID-19 era.", "authors": [{"family": "van de Haar", "given": "Joris", "initials": "J"}, {"family": "Hoes", "given": "Louisa R", "initials": "LR"}, {"family": "Coles", "given": "Charlotte E", "initials": "CE"}, {"family": "Seamon", "given": "Kenneth", "initials": "K"}, {"family": "Fr\u00f6hling", "given": "Stefan", "initials": "S"}, {"family": "J\u00e4ger", "given": "Dirk", "initials": "D"}, {"family": "Valenza", "given": "Franco", "initials": "F"}, {"family": "de Braud", "given": "Filippo", "initials": "F"}, {"family": "De Petris", "given": "Luigi", "initials": "L"}, {"family": "Bergh", "given": "Jonas", "initials": "J"}, {"family": "Ernberg", "given": "Ingemar", "initials": "I"}, {"family": "Besse", "given": "Benjamin", "initials": "B"}, {"family": "Barlesi", "given": "Fabrice", "initials": "F"}, {"family": "Garralda", "given": "Elena", "initials": "E"}, {"family": "Piris-Gim\u00e9nez", "given": "Alejandro", "initials": "A"}, {"family": "Baumann", "given": "Michael", "initials": "M"}, {"family": "Apolone", "given": "Giovanni", "initials": "G"}, {"family": "Soria", "given": "Jean Charles", "initials": "JC"}, {"family": "Tabernero", "given": "Josep", "initials": "J"}, {"family": "Caldas", "given": "Carlos", "initials": "C"}, {"family": "Voest", "given": "Emile E", "initials": "EE"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "volume": "26", "issue": "7", "pages": "1146", "issn-l": "1078-8956"}, "abstract": "An amendment to this paper has been published and can be accessed via a link at the top of the paper.", "doi": "10.1038/s41591-020-0948-7", "pmid": "32494062", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-020-0948-7"}, {"db": "pmc", "key": "PMC7269160"}], "notes": [], "created": "2020-11-25T09:38:02.969Z", "modified": "2020-12-09T10:49:33.755Z"}, {"entity": "publication", "iuid": "34041685e841481e8a7c442c69f3fa9d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/34041685e841481e8a7c442c69f3fa9d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/34041685e841481e8a7c442c69f3fa9d"}}, "title": "Addendum for Euro Surveill. 2020;25(3).", "authors": [{"family": "Eurosurveillance editorial team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "25", "issue": "30", "pages": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.30.2007302", "pmid": "32734858", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7393855"}], "notes": [], "created": "2020-12-07T16:06:30.575Z", "modified": "2020-12-11T12:57:17.295Z"}, {"entity": "publication", "iuid": "5773f521dcfb40b5a8b8f3f58606e0fb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5773f521dcfb40b5a8b8f3f58606e0fb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5773f521dcfb40b5a8b8f3f58606e0fb"}}, "title": "A survey on the impact of the COVID-19 pandemic on motility and functional investigations in Europe and considerations for recommencing activities in the early recovery phase.", "authors": [{"family": "Tack", "given": "Jan", "initials": "J"}, {"family": "Schol", "given": "Jolien", "initials": "J"}, {"family": "Geeraerts", "given": "Annelies", "initials": "A"}, {"family": "Huang", "given": "I-Hsuan", "initials": "I"}, {"family": "Mori", "given": "Hideki", "initials": "H"}, {"family": "Scarpellini", "given": "Emidio", "initials": "E"}, {"family": "Sinonquel", "given": "Pieter", "initials": "P"}, {"family": "Carbone", "given": "Florencia", "initials": "F"}, {"family": "Colomier", "given": "Esther", "initials": "E"}, {"family": "Geysen", "given": "Hannelore", "initials": "H"}, {"family": "Jandee", "given": "Sawangpong", "initials": "S"}, {"family": "Moonen", "given": "An", "initials": "A"}, {"family": "Pannemans", "given": "Jasper", "initials": "J"}, {"family": "Timmermans", "given": "Lien", "initials": "L"}, {"family": "Van den Houte", "given": "Karen", "initials": "K"}, {"family": "Verbeure", "given": "Wout", "initials": "W"}, {"family": "Wauters", "given": "Lucas", "initials": "L"}, {"family": "Bisschops", "given": "Raf", "initials": "R"}, {"family": "Hoffman", "given": "Ilse", "initials": "I"}, {"family": "Roelandt", "given": "Philip", "initials": "P"}, {"family": "Rommel", "given": "Nathalie", "initials": "N"}, {"family": "Simren", "given": "Magnus", "initials": "M"}, {"family": "Suzuki", "given": "Hidekazu", "initials": "H"}, {"family": "Tornblom", "given": "Hans", "initials": "H"}, {"family": "Verbeke", "given": "Kristin", "initials": "K"}, {"family": "Vanuytsel", "given": "Tim", "initials": "T"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Neurogastroenterol Motil", "issn": "1365-2982", "issn-l": null, "volume": "32", "issue": "7", "pages": "e13926"}, "abstract": "The COVID-19 pandemic, declared by WHO on March 13, 2020, had a major global impact on the healthcare system and services. In the acute phase, the presence of the SARS-CoV-2 virus in the aerodigestive tract limited activities in the gastroenterology clinic and procedures to emergencies only. Motility and function testing was interrupted and as we enter the recovery phase, restarting these procedures requires a safety-focused approach with adequate infection prevention for patients and healthcare professionals.\r\n\r\nWe summarized knowledge on the presence of the SARS-CoV-2 virus in the aerodigestive tract and the risk of spread with motility and functional testing. We surveyed 39 European centers documenting how the pandemic affected activities and which measures they are considering for restarting these measurements. We propose recommendations based on current knowledge as applied in our center.\r\n\r\nPositioning of catheters for gastrointestinal motility tests carries a concern for aerosol-borne infection of healthcare workers. The risk is low with breath tests. The surveyed centers stopped almost all motility and function tests from the second half of March. The speed of restarting and the safety measures taken varied highly.\r\n\r\nBased on these findings, we provided recommendations and practical relevant information for motility and function test procedures in the COVID-19 pandemic era, to guarantee a high-quality patient care with adequate infection prevention.", "doi": "10.1111/nmo.13926", "pmid": "32478910", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7300498"}], "notes": [], "created": "2020-12-09T10:55:29.360Z", "modified": "2022-11-10T07:48:14.803Z"}, {"entity": "publication", "iuid": "c508cdc6f84d4fdb8086e170d12eb911", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c508cdc6f84d4fdb8086e170d12eb911.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c508cdc6f84d4fdb8086e170d12eb911"}}, "title": "Safe performance of echocardiography during the COVID-19 pandemic: a practical guide.", "authors": [{"family": "Cameli", "given": "Matteo", "initials": "M"}, {"family": "Pastore", "given": "Maria Concetta", "initials": "MC"}, {"family": "Henein", "given": "Michael", "initials": "M"}, {"family": "Aboumarie", "given": "Hatem Soliman", "initials": "HS"}, {"family": "Mandoli", "given": "Giulia Elena", "initials": "GE"}, {"family": "D'Ascenzi", "given": "Flavio", "initials": "F"}, {"family": "Cameli", "given": "Paolo", "initials": "P"}, {"family": "Franchi", "given": "Federico", "initials": "F"}, {"family": "Mondillo", "given": "Sergio", "initials": "S"}, {"family": "Valente", "given": "Serafina", "initials": "S"}], "type": "journal article", "published": "2020-06-30", "journal": {"title": "Rev Cardiovasc Med", "issn": "1530-6550", "volume": "21", "issue": "2", "pages": "217-223", "issn-l": null}, "abstract": "Coronavirus disease-2019 (COVID-19) outbreak has become a worldwide healthcare emergency, with continuously growing number of infected subjects. Considering the easy virus spread through respiratory droplets produced with cough, sneezes or spit or through close contact with infected people or surfaces, healthcare workers are further exposed to COVID-19. Particularly, echocardiography remains an essential diagnostic service which, due to the close contact with patients during the exam, provides echocardiographers high-risk of contagion. Therefore, the common modalities of performing echocardiography should be improved in this scenario, avoiding performing unnecessary exams, using the appropriate personal protective equipment depending on patients' status and location, optimizing time-effectiveness of the echocardiographic study and accurately sanitizing the environment and devices after each exam. This paper aims to provide a simple guide for the clinicians to balance between providing the best care to each patient and protecting themselves and other patients from the spread of the virus. It also proposes the use of the mnemonic PREVENT to resume the crucial indications to be followed for the execution of appropriate echocardiographic examination during the COVID-19 pandemic.", "doi": "10.31083/j.rcm.2020.02.90", "pmid": "32706210", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "1593391605440-950946668"}], "notes": [], "created": "2020-12-07T16:19:38.826Z", "modified": "2020-12-07T16:19:38.852Z"}, {"entity": "publication", "iuid": "c5eeaacb7f194c1090380a80045ce4da", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5eeaacb7f194c1090380a80045ce4da.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5eeaacb7f194c1090380a80045ce4da"}}, "title": "Olfactory and Gustatory Outcomes in COVID-19: A Prospective Evaluation in Nonhospitalized Subjects.", "authors": [{"family": "Paderno", "given": "Alberto", "initials": "A"}, {"family": "Mattavelli", "given": "Davide", "initials": "D"}, {"family": "Rampinelli", "given": "Vittorio", "initials": "V"}, {"family": "Grammatica", "given": "Alberto", "initials": "A"}, {"family": "Raffetti", "given": "Elena", "initials": "E"}, {"family": "Tomasoni", "given": "Michele", "initials": "M"}, {"family": "Gualtieri", "given": "Tommaso", "initials": "T"}, {"family": "Taboni", "given": "Stefano", "initials": "S"}, {"family": "Zorzi", "given": "Silvia", "initials": "S"}, {"family": "Del Bon", "given": "Francesca", "initials": "F"}, {"family": "Lombardi", "given": "Davide", "initials": "D"}, {"family": "Deganello", "given": "Alberto", "initials": "A"}, {"family": "Redaelli De Zinis", "given": "Luca Oscar", "initials": "LO"}, {"family": "Schreiber", "given": "Alberto", "initials": "A"}], "type": "journal article", "published": "2020-06-30", "journal": {"title": "Otolaryngol Head Neck Surg", "issn": "1097-6817", "volume": "163", "issue": "6", "pages": "194599820939538", "issn-l": "0194-5998"}, "abstract": "To prospectively assess the rate and timing of recovery of olfactory (OD) and gustatory (GD) dysfunction in patients affected by COVID-19.\n\nCohort study.\n\nPopulation-based evaluation in a COVID-19 high-prevalence region.\n\nWe analyzed the clinical course of OD and GD in a cohort of home-quarantined SARS-CoV-2-positive patients from Northern Italy. Physicians administered a survey-based questionnaire at recruitment (T0). During follow-up, patients responded to online dedicated surveys modulated according to symptoms at T0.\n\nA total of 151 patients completed the follow-up survey. OD and/or GD were observed in 83% and 89% of subjects, respectively. Resolution rates of OD and GD at 30 days from onset were 87% and 82%, respectively. Risk factors for late resolution were grade of dysfunction at onset (total vs partial), gender, and presence of nasal congestion. Three (2%) patients previously reporting complete resolution of symptoms complained of subsequent recurrence of OD and/or GD after a mean of 19 days from resolution of the previous episode.\n\nCOVID-19-related OD and GD had high rate of resolution in the first month from onset of symptoms. However, in 10% to 15% of patients, these symptoms showed only partial improvement after this period.", "doi": "10.1177/0194599820939538", "pmid": "32600175", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7331108"}], "notes": [], "created": "2020-11-18T17:12:18.855Z", "modified": "2021-02-26T08:46:13.493Z"}, {"entity": "publication", "iuid": "d5ef2291db25489db53be5bf008166de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5ef2291db25489db53be5bf008166de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5ef2291db25489db53be5bf008166de"}}, "title": "The cholinergic anti-inflammatory pathway alleviates acute lung injury.", "authors": [{"family": "Andersson", "given": "Ulf", "initials": "U"}], "type": "letter", "published": "2020-06-29", "journal": {"title": "Mol Med", "issn": "1528-3658", "volume": "26", "issue": "1", "pages": "64", "issn-l": "1076-1551"}, "abstract": "The ubiquiotous nuclear protein HMGB1 is extracellularly released by dying cells or activated innate immunity cells to promote inflammation. Extracellular HMGB1 plays a prominent role in the pathogenesis of acute lung injury of infectious as well as sterile origin including hyperoxia. Excessive amounts of systemic HMGB1 and HMGB1-partner molecule complexes can be retained in the pulmonary circulation indicated by a substantial reduction of HMGB1 plasma levels in arterial versus venous blood. The cholinergic antiinflammatory mechanism ameliorates pulmonary inflammation by inhibiting HMGB1 release and HMGB1 receptor expression. This comprehension was recently reinforced by results reported in Molecular Medicine by Sitapara and coworkers demonstrating that administration of an \u03b17 nicotinic acetylcholine receptor agonist attenuated hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation. Activating the cholinergic antiinflammatory path might be considered to alleviate severe COVID-19 with or without concurrent oxygen-induced lung injury.", "doi": "10.1186/s10020-020-00184-0", "pmid": "32600316", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s10020-020-00184-0"}, {"db": "pmc", "key": "PMC7322708"}], "notes": [], "created": "2020-12-08T15:25:40.235Z", "modified": "2020-12-08T15:25:40.247Z"}, {"entity": "publication", "iuid": "0274d5946ea445bd80c6f37ead8dfe5e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0274d5946ea445bd80c6f37ead8dfe5e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0274d5946ea445bd80c6f37ead8dfe5e"}}, "title": "Coronavirus Disease Pandemic (COVID-19): Challenges and a Global Perspective.", "authors": [{"family": "Malik", "given": "Yashpal Singh", "initials": "YS"}, {"family": "Kumar", "given": "Naveen", "initials": "N"}, {"family": "Sircar", "given": "Shubhankar", "initials": "S"}, {"family": "Kaushik", "given": "Rahul", "initials": "R"}, {"family": "Bhat", "given": "Sudipta", "initials": "S"}, {"family": "Dhama", "given": "Kuldeep", "initials": "K"}, {"family": "Gupta", "given": "Parakriti", "initials": "P"}, {"family": "Goyal", "given": "Kapil", "initials": "K"}, {"family": "Singh", "given": "Mini P", "initials": "MP"}, {"family": "Ghoshal", "given": "Ujjala", "initials": "U"}, {"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME"}, {"family": "O R", "given": "VinodhKumar", "initials": "V"}, {"family": "Yatoo", "given": "Mohd Iqbal", "initials": "MI"}, {"family": "Tiwari", "given": "Ruchi", "initials": "R"}, {"family": "Pathak", "given": "Mamta", "initials": "M"}, {"family": "Patel", "given": "Shailesh Kumar", "initials": "SK"}, {"family": "Sah", "given": "Ranjit", "initials": "R"}, {"family": "Rodriguez-Morales", "given": "Alfonso J", "initials": "AJ"}, {"family": "Ganesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Kumar", "given": "Prashant", "initials": "P"}, {"family": "Singh", "given": "Raj Kumar", "initials": "RK"}], "type": "journal article", "published": "2020-06-28", "journal": {"title": "Pathogens", "issn": "2076-0817", "volume": "9", "issue": "7", "issn-l": "2076-0817"}, "abstract": "The technology-driven world of the 21 st century is currently confronted with a major threat to humankind, represented by the coronavirus disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome, coronavirus-2 (SARS-CoV-2). As of now, COVID-19 has affected more than 6 million confirmed cases and took 0.39 million human lives. SARS-CoV-2 spreads much faster than its two ancestors, SARS-CoV and Middle East respiratory syndrome-CoV (MERS-CoV), but has low fatality rates. Our analyses speculate that the efficient replication and transmission of SARS-CoV-2 might be due to the high-density basic amino acid residues, preferably positioned in close proximity at both the furin-like cleavage sites (S1/S2 and S2') within the spike protein. Given the high genomic similarities of SARS-CoV-2 to bat SARS-like CoVs, it is likely that bats serve as a reservoir host for its progenitor. Women and children are less susceptible to SARS-CoV-2 infection, while the elderly and people with comorbidities are more prone to serious clinical outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. The cohesive approach amongst researchers across the globe has delivered high-end viral diagnostics. However, home-based point-of-care diagnostics are still under development, which may prove transformative in current COVID-19 pandemic containment. Similarly, vaccines and therapeutics against COVID-19 are currently in the pipeline for clinical trials. In this review, we discuss the noteworthy advancements, focusing on the etiological viral agent, comparative genomic analysis, population susceptibility, disease epidemiology and diagnosis, animal reservoirs, laboratory animal models, disease transmission, therapeutics, vaccine challenges, and disease mitigation measures.", "doi": "10.3390/pathogens9070519", "pmid": "32605194", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "pathogens9070519"}, {"db": "pmc", "key": "PMC7400054"}], "notes": [], "created": "2020-11-19T14:23:51.630Z", "modified": "2020-11-30T08:54:51.546Z"}, {"entity": "publication", "iuid": "e0c42706c478434a9a7dbbba2bba0fc5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e0c42706c478434a9a7dbbba2bba0fc5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e0c42706c478434a9a7dbbba2bba0fc5"}}, "title": "Overcoming fragmentation of health research in Europe: lessons from COVID-19.", "authors": [{"family": "Sipido", "given": "Karin R", "initials": "KR"}, {"family": "Anto\u00f1anzas", "given": "Fernando", "initials": "F"}, {"family": "Celis", "given": "Julio", "initials": "J"}, {"family": "Degos", "given": "Laurent", "initials": "L"}, {"family": "Frackowiak", "given": "Richard", "initials": "R"}, {"family": "Fuster", "given": "Valentin", "initials": "V"}, {"family": "Ganten", "given": "Detlev", "initials": "D"}, {"family": "Gay", "given": "Steffen", "initials": "S"}, {"family": "Hofstraat", "given": "Hans", "initials": "H"}, {"family": "Holgate", "given": "Stephen T", "initials": "ST"}, {"family": "Krestin", "given": "Gabriel", "initials": "G"}, {"family": "Manns", "given": "Michael", "initials": "M"}, {"family": "Meunier", "given": "Francoise", "initials": "F"}, {"family": "Oertel", "given": "Wolfgang", "initials": "W"}, {"family": "Palkonen", "given": "Susanna", "initials": "S"}, {"family": "Pavalkis", "given": "Dainius", "initials": "D"}, {"family": "R\u00fcbsamen-Schaeff", "given": "Helga", "initials": "H"}, {"family": "Smith", "given": "Ulf", "initials": "U"}, {"family": "Stallknecht", "given": "Bente Merete", "initials": "BM"}, {"family": "Zima", "given": "Tom\u00e1\u0161", "initials": "T"}], "type": "letter", "published": "2020-06-27", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "395", "issue": "10242", "pages": "1970-1971", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)31411-2", "pmid": "32559417", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31411-2"}], "notes": [], "created": "2020-12-09T07:45:28.016Z", "modified": "2020-12-09T07:45:28.029Z"}, {"entity": "publication", "iuid": "72abfafc02044690936b841354712977", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/72abfafc02044690936b841354712977.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/72abfafc02044690936b841354712977"}}, "title": "Gendered effects of school closures during the COVID-19 pandemic.", "authors": [{"family": "Burzynska", "given": "Katarzyna", "initials": "K"}, {"family": "Contreras", "given": "Gabriela", "initials": "G"}], "type": "letter", "published": "2020-06-27", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "395", "issue": "10242", "pages": "1968", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)31377-5", "pmid": "32539938", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31377-5"}, {"db": "pmc", "key": "PMC7292576"}], "notes": [], "created": "2020-12-09T07:56:28.304Z", "modified": "2020-12-09T07:56:28.314Z"}, {"entity": "publication", "iuid": "2850cf94d5cb4ab8b9a654e4694fcd05", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2850cf94d5cb4ab8b9a654e4694fcd05.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2850cf94d5cb4ab8b9a654e4694fcd05"}}, "title": "Health equity and COVID-19: global perspectives.", "authors": [{"family": "Shadmi", "given": "Efrat", "initials": "E"}, {"family": "Chen", "given": "Yingyao", "initials": "Y"}, {"family": "Dourado", "given": "In\u00eas", "initials": "I"}, {"family": "Faran-Perach", "given": "Inbal", "initials": "I"}, {"family": "Furler", "given": "John", "initials": "J"}, {"family": "Hangoma", "given": "Peter", "initials": "P"}, {"family": "Hanvoravongchai", "given": "Piya", "initials": "P"}, {"family": "Obando", "given": "Claudia", "initials": "C"}, {"family": "Petrosyan", "given": "Varduhi", "initials": "V"}, {"family": "Rao", "given": "Krishna D", "initials": "KD"}, {"family": "Ruano", "given": "Ana Lorena", "initials": "AL"}, {"family": "Shi", "given": "Leiyu", "initials": "L"}, {"family": "de Souza", "given": "Luis Eugenio", "initials": "LE"}, {"family": "Spitzer-Shohat", "given": "Sivan", "initials": "S"}, {"family": "Sturgiss", "given": "Elizabeth", "initials": "E"}, {"family": "Suphanchaimat", "given": "Rapeepong", "initials": "R"}, {"family": "Uribe", "given": "Manuela Villar", "initials": "MV"}, {"family": "Willems", "given": "Sara", "initials": "S"}], "type": "letter", "published": "2020-06-26", "journal": {"title": "Int J Equity Health", "issn": "1475-9276", "volume": "19", "issue": "1", "pages": "104", "issn-l": null}, "abstract": "The COVID-19 is disproportionally affecting the poor, minorities and a broad range of vulnerable populations, due to its inequitable spread in areas of dense population and limited mitigation capacity due to high prevalence of chronic conditions or poor access to high quality public health and medical care. Moreover, the collateral effects of the pandemic due to the global economic downturn, and social isolation and movement restriction measures, are unequally affecting those in the lowest power strata of societies. To address the challenges to health equity and describe some of the approaches taken by governments and local organizations, we have compiled 13 country case studies from various regions around the world: China, Brazil, Thailand, Sub Saharan Africa, Nicaragua, Armenia, India, Guatemala, United States of America (USA), Israel, Australia, Colombia, and Belgium. This compilation is by no-means representative or all inclusive, and we encourage researchers to continue advancing global knowledge on COVID-19 health equity related issues, through rigorous research and generation of a strong evidence base of new empirical studies in this field.", "doi": "10.1186/s12939-020-01218-z", "pmid": "32586388", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12939-020-01218-z"}, {"db": "pmc", "key": "PMC7316580"}], "notes": [], "created": "2020-12-08T15:49:56.457Z", "modified": "2020-12-08T15:49:56.479Z"}, {"entity": "publication", "iuid": "721dbc34e48a45b0a8d08caa5f332526", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/721dbc34e48a45b0a8d08caa5f332526.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/721dbc34e48a45b0a8d08caa5f332526"}}, "title": "Are official confirmed cases and fatalities counts good enough to study the COVID-19 pandemic dynamics? A critical assessment through the case of Italy.", "authors": [{"family": "Bartoszek", "given": "Krzysztof", "initials": "K"}, {"family": "Guidotti", "given": "Emanuele", "initials": "E"}, {"family": "Iacus", "given": "Stefano Maria", "initials": "SM"}, {"family": "Okr\u00f3j", "given": "Marcin", "initials": "M"}], "type": "journal article", "published": "2020-06-26", "journal": {"title": "Nonlinear Dyn", "issn": "0924-090X", "volume": null, "issue": null, "pages": "1-29", "issn-l": null}, "abstract": "As the COVID-19 outbreak is developing the two most frequently reported statistics seem to be the raw confirmed case and case fatalities counts. Focusing on Italy, one of the hardest hit countries, we look at how these two values could be put in perspective to reflect the dynamics of the virus spread. In particular, we find that merely considering the confirmed case counts would be very misleading. The number of daily tests grows, while the daily fraction of confirmed cases to total tests has a change point. It (depending on region) generally increases with strong fluctuations till (around, depending on region) 15-22 March and then decreases linearly after. Combined with the increasing trend of daily performed tests, the raw confirmed case counts are not representative of the situation and are confounded with the sampling effort. This we observe when regressing on time the logged fraction of positive tests and for comparison the logged raw confirmed count. Hence, calibrating model parameters for this virus's dynamics should not be done based only on confirmed case counts (without rescaling by the number of tests), but take also fatalities and hospitalization count under consideration as variables not prone to be distorted by testing efforts. Furthermore, reporting statistics on the national level does not say much about the dynamics of the disease, which are taking place at the regional level. These findings are based on the official data of total death counts up to 15 April 2020 released by ISTAT and up to 10 May 2020 for the number of cases. In this work, we do not fit models but we rather investigate whether this task is possible at all. This work also informs about a new tool to collect and harmonize official statistics coming from different sources in the form of a package for the R statistical environment and presents the \"COVID-19 Data Hub.\"", "doi": "10.1007/s11071-020-05761-w", "pmid": "32836808", "labels": {"Type: Other": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "5761"}, {"db": "pmc", "key": "PMC7319224"}], "notes": [], "created": "2020-12-07T10:39:54.736Z", "modified": "2021-02-26T08:46:13.245Z"}, {"entity": "publication", "iuid": "9311ddb1127943c3925f38dd3fc1584b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9311ddb1127943c3925f38dd3fc1584b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9311ddb1127943c3925f38dd3fc1584b"}}, "title": "SARS-COV-2 and biomimetics: What saves the planet will save our health.", "authors": [{"family": "Stenvinkel", "given": "P", "initials": "P"}, {"family": "Painer", "given": "J", "initials": "J"}, {"family": "Shiels", "given": "P G", "initials": "PG"}, {"family": "Bansal", "given": "A", "initials": "A"}, {"family": "Fereidouni", "given": "S", "initials": "S"}, {"family": "Natterson-Horowitz", "given": "B", "initials": "B"}, {"family": "Johnson", "given": "R J", "initials": "RJ"}, {"family": "Miranda", "given": "J J", "initials": "JJ"}], "type": "journal article", "published": "2020-06-24", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1111/joim.13128", "pmid": "32583447", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7361468"}], "notes": [], "created": "2020-12-08T15:53:33.978Z", "modified": "2020-12-08T15:53:33.989Z"}, {"entity": "publication", "iuid": "abda8a50c38944a1a031a24d005c13cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abda8a50c38944a1a031a24d005c13cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abda8a50c38944a1a031a24d005c13cc"}}, "title": "Modeling quarantine during epidemics and mass-testing using drones.", "authors": [{"family": "Sedov", "given": "Leonid", "initials": "L"}, {"family": "Krasnochub", "given": "Alexander", "initials": "A"}, {"family": "Polishchuk", "given": "Valentin", "initials": "V"}], "type": "journal article", "published": "2020-06-24", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "15", "issue": "6", "pages": "e0235307", "issn-l": "1932-6203"}, "abstract": "We extend the classical SIR epidemic spread model by introducing the \"quarantined\" compartment. We solve (numerically) the differential equations that govern the extended model and quantify how quarantining \"flattens the curve\" for the proportion of infected population over time. Furthermore, we explore the potential of using drones to deliver tests, enabling mass-testing for the infection; we give a method to estimate the drone fleet needed to deliver the tests in a metropolitan area. Application of our models to COVID-19 spread in Sweden shows how the proposed methods could substantially decrease the peak number of infected people, almost without increasing the duration of the epidemic.", "doi": "10.1371/journal.pone.0235307", "pmid": "32579590", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-11647"}, {"db": "pmc", "key": "PMC7314055"}], "notes": [], "created": "2020-12-08T15:54:48.116Z", "modified": "2020-12-08T15:54:48.127Z"}, {"entity": "publication", "iuid": "eb49878592064e0ab759503cd2c0537d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb49878592064e0ab759503cd2c0537d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb49878592064e0ab759503cd2c0537d"}}, "title": "Simulation-based skills training in non-performing orthopedic surgeons: skills acquisition, motivation, and flow during the COVID-19 pandemic.", "authors": [{"family": "Hedman", "given": "Leif Rune", "initials": "LR"}, {"family": "Fell\u00e4nder-Tsai", "given": "Li", "initials": "L"}], "type": "journal article", "published": "2020-06-23", "journal": {"title": "Acta Orthop", "issn": "1745-3682", "volume": null, "issue": null, "pages": "1-5", "issn-l": null}, "abstract": null, "doi": "10.1080/17453674.2020.1781413", "pmid": "32573303", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-08T16:24:35.275Z", "modified": "2020-12-08T16:24:35.296Z"}, {"entity": "publication", "iuid": "9dfda2d805a9485fa5c8459fbd46db7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9dfda2d805a9485fa5c8459fbd46db7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9dfda2d805a9485fa5c8459fbd46db7a"}}, "title": "Re-positive Cases of Nucleic Acid Tests in Discharged Patients With COVID-19: A Follow-Up Study.", "authors": [{"family": "Qiao", "given": "Xi-Min", "initials": "XM"}, {"family": "Xu", "given": "Xiao-Feng", "initials": "XF"}, {"family": "Zi", "given": "Hao", "initials": "H"}, {"family": "Liu", "given": "Guo-Xiong", "initials": "GX"}, {"family": "Li", "given": "Bing-Hui", "initials": "BH"}, {"family": "Du", "given": "Xiang", "initials": "X"}, {"family": "Tian", "given": "Zhi-Hai", "initials": "ZH"}, {"family": "Liu", "given": "Xiao-Ying", "initials": "XY"}, {"family": "Luo", "given": "Li-Sha", "initials": "LS"}, {"family": "Wang", "given": "Xiao", "initials": "X"}], "type": "journal article", "published": "2020-06-23", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "7", "issue": null, "pages": "349", "issn-l": null}, "abstract": "Background: The frequent emergence of the re-positive patients with COVID-19 is a potential threat worldwide. This study aimed to describe data from admission to follow-up for patients with COVID-19 and analyze the possible causes for re-positive nucleic acid tests to provide more scientific basis for reducing the numbers of re-positive patients after discharge. Methods: We retrospectively recorded 15 patients with COVID-19 admitted to the Xianyang Central Hospital, China. The baseline, exposure histories, clinical syndromes, laboratory characteristics, nucleic acid, and follow-up tests were analyzed, and the radiological characteristics of re-positive patient at different periods were compared. Results: Eight (53.33%) patients had the history of travel to Wuhan, four (26.67%) patients had close contact with confirmed patients, and one (6.67%) patient had close contact with suspected patients. After treatment, all patients had two consecutively negative nucleic acid tests and were discharged from hospital. All patients were followed up for more than 14 days, and the average time from discharge to the first follow-up was 14.67 \u00b1 3.31 days (from 9 to 22 days). Most patients showed no clinical symptoms and negative nucleic acid tests, while one patient had an itchy throat, her CT scan showed a light density shadow in the right lower lobe of the lung, and the nucleic acid was once again positive. The second follow-up of the other 14 patients (except the re-positive one) was conducted 20.80 \u00b1 7.78 days (from 13 to 30 days) after discharge, and all of them had negative nucleic acid tests. The positive patient was immediately readmitted and received a new round of treatment. Her family members and colleagues remained healthy until now. Conclusions: The quality of nucleic acid testing reagents should be enhanced, and the training of nucleic acid sampling operators should be strengthened to reduce the false-negative results in the nucleic acid of SARS-CoV-2; the clinical specimens of throat and nasopharynx swabs can be collected at the same time; IgM- and IgG-specific antibodies of SARS-CoV-2 should be carried out for discharged patients; the radiological characteristics should be evaluated strictly; and the discharge standard can be specified according to the baseline and severity of disease of patients.", "doi": "10.3389/fmed.2020.00349", "pmid": "32656223", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "All data provided in the article", "description": null}], "notes": [], "created": "2020-12-08T14:14:57.177Z", "modified": "2021-02-26T08:45:48.527Z"}, {"entity": "publication", "iuid": "9428858ffe57443e8565e9bc0c31a4de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9428858ffe57443e8565e9bc0c31a4de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9428858ffe57443e8565e9bc0c31a4de"}}, "title": "Maximizing Safety in the Conduct of Alzheimer's Disease Fluid Biomarker Research in the Era of COVID-19.", "authors": [{"family": "Schindler", "given": "Suzanne E", "initials": "SE"}, {"family": "Jicha", "given": "Gregory A", "initials": "GA"}, {"family": "Nelson", "given": "Peter T", "initials": "PT"}, {"family": "Keene", "given": "C Dirk", "initials": "CD"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Molinuevo", "given": "Jos\u00e9 Luis", "initials": "JL"}, {"family": "Masters", "given": "Colin L", "initials": "CL"}, {"family": "Hansson", "given": "Oskar", "initials": "O"}, {"family": "Teunissen", "given": "Charlotte E", "initials": "CE"}, {"family": "Galasko", "given": "Douglas", "initials": "D"}, {"family": "Shaw", "given": "Leslie M", "initials": "LM"}, {"family": "Levey", "given": "Allan I", "initials": "AI"}, {"family": "Silverberg", "given": "Nina", "initials": "N"}], "type": "letter", "published": "2020-06-23", "journal": {"title": "J Alzheimers Dis", "issn": "1875-8908", "volume": "76", "issue": "1", "pages": "27-31", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic led to an abrupt halt of many Alzheimer's disease (AD) research studies at sites spanning the world. This is especially true for studies requiring in-person contact, such as studies collecting biofluids. Since COVID-19 is likely to remain a threat for an extended period, the resumption of fluid biomarker studies requires the development and implementation of procedures that minimize the risk of in-person visits to participants, staff, and individuals handling the biofluid samples. Some issues to consider include structuring the visit workflow to minimize contacts and promote social distancing; screening and/or testing participants and staff for COVID-19; wearing masks and performing hand hygiene; and precautions for handling, storing, and analyzing biofluids. AD fluid biomarker research remains a vitally important public health priority and resuming studies requires appropriate safety procedures to protect research participants and staff.", "doi": "10.3233/JAD-200684", "pmid": "32568212", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "JAD200684"}], "notes": [], "created": "2020-12-08T16:29:25.802Z", "modified": "2020-12-08T16:29:25.825Z"}, {"entity": "publication", "iuid": "26a3f95ac88b41c4a35b29165a82f0e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26a3f95ac88b41c4a35b29165a82f0e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26a3f95ac88b41c4a35b29165a82f0e7"}}, "title": "Does a surgical helmet provide protection against aerosol transmitted disease?", "authors": [{"family": "Temmesfeld", "given": "Max Joachim", "initials": "MJ"}, {"family": "Jakobsen", "given": "Rune Bruhn", "initials": "RB"}, {"family": "Grant", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2020-06-23", "journal": {"title": "Acta Orthop", "issn": "1745-3682", "volume": null, "issue": null, "pages": "1-5", "issn-l": null}, "abstract": "Background and purpose - The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to a global shortage of personal protective equipment (PPE). Various alternatives to ordinary PPE have been suggested to reduce transmission, which is primarily through droplets and aerosols. For many years orthopedic surgeons have been using surgical helmets as personal protection against blood-borne pathogens during arthroplasty surgery. We have investigated the possibility of using the Stryker Flyte surgical helmet as a respiratory protective device against airborne- and droplet-transmitted disease, since the helmet shares many features with powered air-purifying respirators.Materials and methods - Using an aerosol particle generator, we determined the filtration capacity of the Stryker Flyte helmet by placing particle counters measuring the concentrations of 0.3, 0.5, and 5 \u00b5m particles inside and outside of the helmet.Results - We found that the helmet has insufficient capacity for filtrating aerosol particles, and, for 0.3 \u00b5m sized particles, we even recorded an accumulation of particles inside the helmet.Interpretation - We conclude that the Stryker Flyte surgical helmet should not be used as a respiratory protective device when there is a risk for exposure to aerosol containing SARS-CoV-2, the virus causing COVID-19, in accordance with the recommendation from the manufacturer.", "doi": "10.1080/17453674.2020.1771525", "pmid": "32573285", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-08T16:25:11.699Z", "modified": "2020-12-08T16:25:11.711Z"}, {"entity": "publication", "iuid": "2370821b31b14cf8a22f331c2d6bbe77", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2370821b31b14cf8a22f331c2d6bbe77.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2370821b31b14cf8a22f331c2d6bbe77"}}, "title": "COVID-19 IDD: A global survey exploring the impact of COVID-19 on individuals with intellectual and developmental disabilities and their caregivers.", "authors": [{"family": "Linehan", "given": "Christine", "initials": "C"}, {"family": "Araten-Bergam", "given": "Tal", "initials": "T"}, {"family": "Beadle-Brown", "given": "Julie", "initials": "J"}, {"family": "Bigby", "given": "Christine", "initials": "C"}, {"family": "Birkbeck", "given": "Gail", "initials": "G"}, {"family": "Bradley", "given": "Valerie", "initials": "V"}, {"family": "Brown", "given": "Michael", "initials": "M"}, {"family": "Bredewold", "given": "Femmianne", "initials": "F"}, {"family": "Chirwa", "given": "Masauso", "initials": "M"}, {"family": "Kanova", "given": "Sarka", "initials": "S"}, {"family": "Kroll", "given": "Thilo", "initials": "T"}, {"family": "MacLachlan", "given": "Mac", "initials": "M"}, {"family": "Narayan", "given": "Jayanthi", "initials": "J"}, {"family": "Nearchou", "given": "Finiki", "initials": "F"}, {"family": "Nolan", "given": "Adam", "initials": "A"}, {"family": "O'Donovan", "given": "Mary-Ann", "initials": "MA"}, {"family": "Santos", "given": "Flavia H", "initials": "FH"}, {"family": "Siska", "given": "Jan", "initials": "J"}, {"family": "Tideman", "given": "Magnus", "initials": "M"}, {"family": "Tossebro", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2020-06-23", "journal": {"title": "HRB Open Res", "issn": "2515-4826", "volume": "3", "issue": null, "pages": "39", "issn-l": null}, "abstract": "Background: This protocol outlines research to explore the impact of coronavirus disease 2019 (COVID-19) on individuals who have intellectual and developmental disabilities and their caregivers. Evidence suggests that people with intellectual and developmental disabilities experience disparities in healthcare access and utilisation. This disparity was evident early in the pandemic when discussions arose regarding the potential exclusion of this population to critical care. Methods: An anonymous online survey will be conducted with caregivers, both family members and paid staff, to explore the impact of COVID-19 on this population in terms of demographics, living arrangements, access to services, the impact of social distancing, and also carer wellbeing. The survey will be developed by the research team, many of whom are experts in intellectual disability within their own jurisdictions. Using back-translation our team will translate the survey for distribution in 16 countries worldwide for international comparison. The survey team have extensive personal and professional networks in intellectual disability and will promote the survey widely on social media with the support of local disability and advocacy agencies. Statistical descriptive and comparative analyses will be conducted. Ethical approval has been obtained for this study from University College Dublin's Human Research Ethics Committee (HS-20-28-Linehan). Dissemination: Study findings will be prepared in a number of formats in order to meet the needs of different audiences. Outputs will include academic papers, lessons learned paper, practice guidelines, reports, infographics and video content. These outputs will be directed to families, frontline and management delivering disability services, national-level policy makers, healthcare quality and delivery authorities, national pandemic organisations and international bodies.", "doi": "10.12688/hrbopenres.13077.1", "pmid": "33392440", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7745183"}], "notes": [], "created": "2021-01-05T15:17:20.252Z", "modified": "2021-02-26T08:46:59.862Z"}, {"entity": "publication", "iuid": "0ddad22d61894a518568a0db3ecbf194", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ddad22d61894a518568a0db3ecbf194.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ddad22d61894a518568a0db3ecbf194"}}, "title": "Creating misinformation: how a headline in The BMJ about covid-19 spread virally.", "authors": [{"family": "Winters", "given": "Maike", "initials": "M"}, {"family": "Oppenheim", "given": "Ben", "initials": "B"}, {"family": "Pick", "given": "Jonas", "initials": "J"}, {"family": "Nordenstedt", "given": "Helena", "initials": "H"}], "type": "letter", "published": "2020-06-18", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "369", "issue": null, "pages": "m2384", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m2384", "pmid": "32554782", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-09T07:46:47.709Z", "modified": "2020-12-09T07:46:47.718Z"}, {"entity": "publication", "iuid": "4c3bed3cd46f43f491164d00cd961e01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4c3bed3cd46f43f491164d00cd961e01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4c3bed3cd46f43f491164d00cd961e01"}}, "title": "The Coronavirus Pandemic and Lessons Learned in Preschools in Norway, Sweden and the United States: OMEP Policy Forum.", "authors": [{"family": "Pramling Samuelsson", "given": "Ingrid", "initials": "I"}, {"family": "Wagner", "given": "Judith T", "initials": "JT"}, {"family": "Eriksen \u00d8degaard", "given": "Elin", "initials": "E"}], "type": "journal article", "published": "2020-06-17", "journal": {"title": "Int J Early Child", "issn": "0020-7187", "volume": null, "issue": null, "pages": "1-16", "issn-l": null}, "abstract": "The novel coronavirus, also known as COVID-19, has moved rapidly across the world in 2020. This article reports on the recent consequences of the pandemic for early childhood education in Sweden, Norway, and the United States. The authors illustrate the effects of the pandemic on preschools in their countries, against a backdrop of frequent changes in infection and mortality rates, epidemiological understandings, government strategies, and mitigation strategies regarding preschool closures. Teachers report their experiences and actions in specific early childhood education settings, across the three national contexts. These experiential snapshots identify program priorities, parents' and children's reactions, and the commitment and concerns of teachers. The conversations reveal culturally situated similarities of early childhood educational practices but also differences across contexts. Teachers report on the challenges of their experiences but also benefits for their practice and how they engage with children and their families. Ideas about future preparedness for such pandemics are also discussed.", "doi": "10.1007/s13158-020-00267-3", "pmid": "32836368", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "267"}, {"db": "pmc", "key": "PMC7299556"}], "notes": [], "created": "2020-12-07T11:39:17.525Z", "modified": "2020-12-07T11:39:17.551Z"}, {"entity": "publication", "iuid": "49b89c9d3b9b4722899f24bbfcfa22fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49b89c9d3b9b4722899f24bbfcfa22fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49b89c9d3b9b4722899f24bbfcfa22fa"}}, "title": "Strategy for Disease Diagnosis, Progression Prediction, Risk Group Stratification and Treatment-Case of COVID-19.", "authors": [{"family": "Vihinen", "given": "Mauno", "initials": "M"}], "type": "journal article", "published": "2020-06-16", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "7", "issue": null, "pages": "294", "issn-l": null}, "abstract": "A novel strategy is presented for reliable diagnosis and progression prediction of diseases with special attention to COVID-19 pandemic. A plan is presented for how the model can be implemented worldwide in healthcare and how novel treatments and targets can be detected. The idea is based on poikilosis, pervasive heterogeneity, and variation at all levels, systems, and mechanisms. Poikilosis in diseases can be taken into account in pathogenicity model, which is based on distribution of three independent condition measures-extent, modulation, and severity. Pathogenicity model is a population or cohort-based description of disease components. Evidence-based thresholds can be applied to the pathogenicity model and used for diagnosis as well as for early detection of patients in risk of developing the most severe forms of the disease. Analysis of patients with differential course of disease can help in detecting biomarkers of diagnostic and prognostic significance. A practical and feasible plan is presented how the concepts can be implemented in practice. Collaboration of many actors, including the World Health Organization and national health authorities, will be essential for success.", "doi": "10.3389/fmed.2020.00294", "pmid": "32613004", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7308420"}], "notes": [], "created": "2020-12-08T15:19:35.899Z", "modified": "2020-12-08T15:19:35.908Z"}, {"entity": "publication", "iuid": "8a9bb861986d4d25b069df3861b0bc3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a9bb861986d4d25b069df3861b0bc3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a9bb861986d4d25b069df3861b0bc3d"}}, "title": "Ethical Criteria for the Admission and Management of Patients in the ICU Under Conditions of Limited Medical Resources: A Shared International Proposal in View of the COVID-19 Pandemic.", "authors": [{"family": "Tambone", "given": "Vittoradolfo", "initials": "V"}, {"family": "Boudreau", "given": "Donald", "initials": "D"}, {"family": "Ciccozzi", "given": "Massimo", "initials": "M"}, {"family": "Sanders", "given": "Karen", "initials": "K"}, {"family": "Campanozzi", "given": "Laura Leondina", "initials": "LL"}, {"family": "Wathuta", "given": "Jane", "initials": "J"}, {"family": "Violante", "given": "Luciano", "initials": "L"}, {"family": "Cauda", "given": "Roberto", "initials": "R"}, {"family": "Petrini", "given": "Carlo", "initials": "C"}, {"family": "Abbate", "given": "Antonio", "initials": "A"}, {"family": "Alloni", "given": "Rossana", "initials": "R"}, {"family": "Argemi", "given": "Josepmaria", "initials": "J"}, {"family": "Argem\u00ed Renom", "given": "Josep", "initials": "J"}, {"family": "De Benedictis", "given": "Anna", "initials": "A"}, {"family": "Galerneau", "given": "France", "initials": "F"}, {"family": "Garc\u00eda-S\u00e1nchez", "given": "Emilio", "initials": "E"}, {"family": "Ghilardi", "given": "Giampaolo", "initials": "G"}, {"family": "Hafler", "given": "Janet Palmer", "initials": "JP"}, {"family": "Linden", "given": "Magdalena", "initials": "M"}, {"family": "Marcos", "given": "Alfredo", "initials": "A"}, {"family": "Onetti Muda", "given": "Andrea", "initials": "A"}, {"family": "Pandolfi", "given": "Marco", "initials": "M"}, {"family": "Pelaccia", "given": "Thierry", "initials": "T"}, {"family": "Picozzi", "given": "Mario", "initials": "M"}, {"family": "Revello", "given": "Ruben Oscar", "initials": "RO"}, {"family": "Ricci", "given": "Giovanna", "initials": "G"}, {"family": "Rohrbaugh", "given": "Robert", "initials": "R"}, {"family": "Rossi", "given": "Patrizio", "initials": "P"}, {"family": "Sirignano", "given": "Ascanio", "initials": "A"}, {"family": "Spagnolo", "given": "Antonio Gioacchino", "initials": "AG"}, {"family": "Stammers", "given": "Trevor", "initials": "T"}, {"family": "Vel\u00e1zquez", "given": "Lourdes", "initials": "L"}, {"family": "Agazzi", "given": "Evandro", "initials": "E"}, {"family": "Mercurio", "given": "Mark", "initials": "M"}], "type": "journal article", "published": "2020-06-16", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "284", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2020.00284", "pmid": "32612972", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7308475"}], "notes": [], "created": "2020-12-08T15:20:15.113Z", "modified": "2020-12-08T15:20:15.122Z"}, {"entity": "publication", "iuid": "6e1934b517a94c6b8dad3b638f75caca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e1934b517a94c6b8dad3b638f75caca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e1934b517a94c6b8dad3b638f75caca"}}, "title": "Evaluation of the English Version of the Fear of COVID-19 Scale and Its Relationship with Behavior Change and Political Beliefs.", "authors": [{"family": "Winter", "given": "Taylor", "initials": "T"}, {"family": "Riordan", "given": "Benjamin C", "initials": "BC"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Mason", "given": "Andre", "initials": "A"}, {"family": "Poulgrain", "given": "John W", "initials": "JW"}, {"family": "Scarf", "given": "Damian", "initials": "D"}], "type": "journal article", "published": "2020-06-15", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "volume": null, "issue": null, "pages": "1-11", "issn-l": null}, "abstract": "The COVID-19 pandemic has many individuals around the world fearing for their lives. The constant news coverage, rapid transmission, and relatively high mortality rate, make fearfulness a natural response. To assess the fear of COVID-19, the Fear of COVID-19 Scale (FCV-19S) was developed. The primary aim of the present study was to conduct the first psychometric assessment and validation of the English version of the FCV-19S. Two samples were collected in New Zealand. Sample 1 comprised 1624 participants of which 1397 completed all questions and were used in the analyses. Sample 2 comprised 1111 participants of which 1023 completed all questions and were used in the analyses. Several psychometric tests were conducted to ascertain the scale's reliability and validity. Across both samples, the FCV-19S had high internal consistency. Consistent with the earlier validation studies, the FCV-19S displayed a moderately strong relationship with the perceived infectability and germ aversion subscales of the perceived vulnerability to disease scale (PVDS). Furthermore, FCV-19S scores were negatively correlated with the Warwick-Edinburgh Mental Wellbeing Scale (WEMWBS) scores. With respect to the motivating role of fear, there was a significant relationship between FCV-19S scores and adherence to the lockdown rules that were implemented in New Zealand. Finally, consistent with recent reports on the politicization of the COVID-19 pandemic, an exploratory question found that participants who rated themselves as more conservative tended to report lower FCV-19S scores. The English version of the COVID-19S is a sound unidimensional scale with robust psychometric properties and can be used with confidence among English-speaking populations.", "doi": "10.1007/s11469-020-00342-9", "pmid": "32837431", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "342"}, {"db": "pmc", "key": "PMC7295324"}], "notes": [], "created": "2020-12-07T10:35:30.325Z", "modified": "2021-02-26T08:45:48.294Z"}, {"entity": "publication", "iuid": "2d6e328ee4c3402cb4cf9ce713a48b68", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d6e328ee4c3402cb4cf9ce713a48b68.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d6e328ee4c3402cb4cf9ce713a48b68"}}, "title": "Analysing the Combined Health, Social and Economic Impacts of the Corovanvirus Pandemic Using Agent-Based Social Simulation.", "authors": [{"family": "Dignum", "given": "Frank", "initials": "F"}, {"family": "Dignum", "given": "Virginia", "initials": "V"}, {"family": "Davidsson", "given": "Paul", "initials": "P"}, {"family": "Ghorbani", "given": "Amineh", "initials": "A"}, {"family": "van der Hurk", "given": "Mijke", "initials": "M"}, {"family": "Jensen", "given": "Maarten", "initials": "M"}, {"family": "Kammler", "given": "Christian", "initials": "C"}, {"family": "Lorig", "given": "Fabian", "initials": "F"}, {"family": "Ludescher", "given": "Luis Gustavo", "initials": "LG"}, {"family": "Melchior", "given": "Alexander", "initials": "A"}, {"family": "Mellema", "given": "Ren\u00e9", "initials": "R"}, {"family": "Pastrav", "given": "Cezara", "initials": "C"}, {"family": "Vanhee", "given": "Lo\u00efs", "initials": "L"}, {"family": "Verhagen", "given": "Harko", "initials": "H"}], "type": "journal article", "published": "2020-06-15", "journal": {"title": "Minds Mach (Dordr)", "issn": "0924-6495", "volume": null, "issue": null, "pages": "1-18", "issn-l": null}, "abstract": "During the COVID-19 crisis there have been many difficult decisions governments and other decision makers had to make. E.g. do we go for a total lock down or keep schools open? How many people and which people should be tested? Although there are many good models from e.g. epidemiologists on the spread of the virus under certain conditions, these models do not directly translate into the interventions that can be taken by government. Neither can these models contribute to understand the economic and/or social consequences of the interventions. However, effective and sustainable solutions need to take into account this combination of factors. In this paper, we propose an agent-based social simulation tool, ASSOCC, that supports decision makers understand possible consequences of policy interventions, but exploring the combined social, health and economic consequences of these interventions.", "doi": "10.1007/s11023-020-09527-6", "pmid": "32836870", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "9527"}, {"db": "pmc", "key": "PMC7294191"}], "notes": [], "created": "2020-12-07T10:38:03.484Z", "modified": "2020-12-07T10:38:12.876Z"}, {"entity": "publication", "iuid": "e97cac63bbe14a28bca026bd3303fab7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e97cac63bbe14a28bca026bd3303fab7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e97cac63bbe14a28bca026bd3303fab7"}}, "title": "Rotational Thromboelastometry predicts care level in COVID-19", "authors": [{"family": "Almskog", "given": "Lou M", "initials": "LM"}, {"family": "Wikman", "given": "Agneta", "initials": "A"}, {"family": "Svensson", "given": "Jonas", "initials": "J"}, {"family": "Wanecek", "given": "Michael", "initials": "M"}, {"family": "Bottai", "given": "Matteo", "initials": "M"}, {"family": "van der Linden", "given": "Jan", "initials": "J"}, {"family": "\u00c5gren", "given": "Anna", "initials": "A"}], "type": "posted-content", "published": "2020-06-12", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.06.11.20128710", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-17T19:32:22.986Z", "modified": "2021-05-18T08:00:25.274Z"}, {"entity": "publication", "iuid": "8341c717ee3f4a4a98ccae033bcad53b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8341c717ee3f4a4a98ccae033bcad53b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8341c717ee3f4a4a98ccae033bcad53b"}}, "title": "Has Sweden's controversial covid-19 strategy been successful?", "authors": [{"family": "Habib", "given": "Heba", "initials": "H"}], "type": "journal article", "published": "2020-06-12", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "369", "issue": null, "pages": "m2376", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m2376", "pmid": "32532807", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-09T07:57:08.125Z", "modified": "2020-12-09T07:57:08.135Z"}, {"entity": "publication", "iuid": "0d5ace8c4e674605b00185201e9bfcbd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d5ace8c4e674605b00185201e9bfcbd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d5ace8c4e674605b00185201e9bfcbd"}}, "title": "COVID-19 pandemic: Practical considerations on the organization of an allergy clinic - an EAACI/ARIA Position Paper.", "authors": [{"family": "Pfaar", "given": "O", "initials": "O"}, {"family": "Klimek", "given": "L", "initials": "L"}, {"family": "Jutel", "given": "M", "initials": "M"}, {"family": "Akdis", "given": "C A", "initials": "CA"}, {"family": "Bousquet", "given": "J", "initials": "J"}, {"family": "Breiteneder", "given": "H", "initials": "H"}, {"family": "Chinthrajah", "given": "S", "initials": "S"}, {"family": "Diamant", "given": "Z", "initials": "Z"}, {"family": "Eiwegger", "given": "T", "initials": "T"}, {"family": "Fokkens", "given": "W J", "initials": "WJ"}, {"family": "Fritsch", "given": "H W", "initials": "HW"}, {"family": "Nadeau", "given": "K C", "initials": "KC"}, {"family": "O'Hehir", "given": "R E", "initials": "RE"}, {"family": "O'Mahony", "given": "L", "initials": "L"}, {"family": "Rief", "given": "W", "initials": "W"}, {"family": "Sampath", "given": "V", "initials": "V"}, {"family": "Schedlowski", "given": "M", "initials": "M"}, {"family": "Torres", "given": "M", "initials": "M"}, {"family": "Traidl-Hoffmann", "given": "C", "initials": "C"}, {"family": "Wang", "given": "D Y", "initials": "DY"}, {"family": "Zhang", "given": "L", "initials": "L"}, {"family": "Bonini", "given": "M", "initials": "M"}, {"family": "Brehler", "given": "R", "initials": "R"}, {"family": "Brough", "given": "H A", "initials": "HA"}, {"family": "Chivato", "given": "T", "initials": "T"}, {"family": "Del Giacco", "given": "S", "initials": "S"}, {"family": "Dramburg", "given": "S", "initials": "S"}, {"family": "Gawlik", "given": "R", "initials": "R"}, {"family": "Gelincik", "given": "A", "initials": "A"}, {"family": "Hoffmann-Sommergruber", "given": "K", "initials": "K"}, {"family": "Hox", "given": "V", "initials": "V"}, {"family": "Knol", "given": "E", "initials": "E"}, {"family": "Lauerma", "given": "A", "initials": "A"}, {"family": "Matricardi", "given": "P M", "initials": "PM"}, {"family": "Mortz", "given": "C G", "initials": "CG"}, {"family": "Ollert", "given": "M", "initials": "M"}, {"family": "Palomares", "given": "O", "initials": "O"}, {"family": "Riggioni", "given": "C", "initials": "C"}, {"family": "Schwarze", "given": "J", "initials": "J"}, {"family": "Skypala", "given": "I", "initials": "I"}, {"family": "Untersmayr", "given": "S", "initials": "S"}, {"family": "Walusiak-Skorupa", "given": "J", "initials": "J"}, {"family": "Ansotegui", "given": "I", "initials": "I"}, {"family": "Bachert", "given": "C", "initials": "C"}, {"family": "Bedbrook", "given": "A", "initials": "A"}, {"family": "Bosnic-Anticevich", "given": "S", "initials": "S"}, {"family": "Brussino", "given": "L", "initials": "L"}, {"family": "Canonica", "given": "G W", "initials": "GW"}, {"family": "Cardona", "given": "V", "initials": "V"}, {"family": "Carreiro-Martins", "given": "P", "initials": "P"}, {"family": "Cruz", "given": "A A", "initials": "AA"}, {"family": "Czarlewski", "given": "W", "initials": "W"}, {"family": "Fonseca", "given": "J A", "initials": "JA"}, {"family": "Gotua", "given": "M", "initials": "M"}, {"family": "Haatela", "given": "T", "initials": "T"}, {"family": "Ivancevich", "given": "J C", "initials": "JC"}, {"family": "Kuna", "given": "P", "initials": "P"}, {"family": "Kvedariene", "given": "V", "initials": "V"}, {"family": "Larenas-Linnemann", "given": "D", "initials": "D"}, {"family": "Latiff", "given": "A", "initials": "A"}, {"family": "Morais-Almeida", "given": "M", "initials": "M"}, {"family": "Mullol", "given": "J", "initials": "J"}, {"family": "Naclerio", "given": "R", "initials": "R"}, {"family": "Ohta", "given": "K", "initials": "K"}, {"family": "Okamoto", "given": "Y", "initials": "Y"}, {"family": "Onorato", "given": "G L", "initials": "GL"}, {"family": "Papadopoulos", "given": "N G", "initials": "NG"}, {"family": "Patella", "given": "V", "initials": "V"}, {"family": "Regateiro", "given": "F S", "initials": "FS"}, {"family": "Samolinski", "given": "B", "initials": "B"}, {"family": "Suppli Ulrik", "given": "C", "initials": "C"}, {"family": "Toppila-Salmi", "given": "S", "initials": "S"}, {"family": "Valiulis", "given": "A", "initials": "A"}, {"family": "Ventura", "given": "M T", "initials": "MT"}, {"family": "Yorgancioglu", "given": "A", "initials": "A"}, {"family": "Zuberbier", "given": "T", "initials": "T"}, {"family": "Agache", "given": "I", "initials": "I"}], "type": "journal article", "published": "2020-06-12", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": "76", "issue": "3", "pages": "648-676", "issn-l": "0105-4538"}, "abstract": "The Coronavirus disease 2019 (COVID-19) has evolved as a pandemic infectious disease transmitted by the severe acute respiratory syndrome coronavirus (SARS-CoV-)2. Allergists and other health care providers (HCPs) in the field of allergies and associated airway diseases are in the front line, taking care of patients potentially infected with SARS-CoV-2. Hence, strategies and practices to minimize risks of infection for both HCPs and treated patients have to be developed and followed by allergy clinics.\n\nThe scientific information on COVID-19 was analyzed by a literature search in Medline, Pubmed, national and international guidelines from the European Academy of Allergy and Clinical Immunology (EAACI), the Cochrane Library and the Internet.\n\nBased on diagnostic and treatment standards developed by EAACI, on international information regarding COVID-19, on guidelines of the World Health Organization (WHO) and other international organizations as well as on previous experience, a panel of experts including clinicians, psychologists, IT experts and basic scientists along with EAACI and the \"Allergic Rhinitis and its Impact on Asthma (ARIA)\" inititiative have developed recommendations for the optimal management of allergy clinics during the current COVID-19 pandemic. These recommendations are grouped into nine sections on different relevant aspects for the care of patients with allergies.\n\nThis international Position Paper provides recommendations on operational plans and procedures to maintain high standards in the daily clinical care of allergic patients whilst ensuring necessary safety in the current COVID-19 pandemic.", "doi": "10.1111/all.14453", "pmid": "32531110", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7323448"}], "notes": [], "created": "2020-11-25T09:59:36.828Z", "modified": "2021-04-23T16:11:47.867Z"}, {"entity": "publication", "iuid": "162889acebf541c4aa975e0920e09255", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/162889acebf541c4aa975e0920e09255.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/162889acebf541c4aa975e0920e09255"}}, "title": "Proteomic Profiling in Biracial Cohorts Implicates DC-SIGN as a Mediator of Genetic Risk in COVID-19", "authors": [{"family": "Katz", "given": "Daniel H", "initials": "DH", "orcid": "0000-0001-7237-8502", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b20cc0e5af5a45afbd1437ae5f67e1f9.json"}}, {"family": "Tahir", "given": "Usman A", "initials": "UA"}, {"family": "Ngo", "given": "Debby", "initials": "D"}, {"family": "Benson", "given": "Mark", "initials": "M"}, {"family": "Bick", "given": "Alexander G", "initials": "AG"}, {"family": "Pampana", "given": "Akhil", "initials": "A"}, {"family": "Gao", "given": "Yan", "initials": "Y"}, {"family": "Keyes", "given": "Michelle J", "initials": "MJ"}, {"family": "Correa", "given": "Adolfo", "initials": "A"}, {"family": "Sinha", "given": "Sumita", "initials": "S"}, {"family": "Shen", "given": "Dongxiao", "initials": "D"}, {"family": "Yang", "given": "Qiong", "initials": "Q"}, {"family": "Robbins", "given": "Jeremy M", "initials": "JM"}, {"family": "Chen", "given": "Zsu Zsu", "initials": "ZZ"}, {"family": "Cruz", "given": "Daniel E", "initials": "DE"}, {"family": "Peterson", "given": "Bennet", "initials": "B"}, {"family": "Natarajan", "given": "Pradeep", "initials": "P"}, {"family": "Vasan", "given": "Ramachandran S", "initials": "RS"}, {"family": "Smith", "given": "J Gustav", "initials": "JG"}, {"family": "Wang", "given": "Thomas J", "initials": "TJ"}, {"family": "Wilson", "given": "James G", "initials": "JG"}, {"family": "Gerszten", "given": "Robert E", "initials": "RE"}], "type": "posted-content", "published": "2020-06-11", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.06.09.20125690", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Health": null, "Category: Genomics & transcriptomics": null}, "xrefs": [], "notes": [], "created": "2021-06-17T07:59:56.735Z", "modified": "2021-06-17T08:00:14.173Z"}, {"entity": "publication", "iuid": "a11cb5cd27c844e589b01a7d4df0c679", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a11cb5cd27c844e589b01a7d4df0c679.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a11cb5cd27c844e589b01a7d4df0c679"}}, "title": "Associations Between Fear of COVID-19, Mental Health, and Preventive Behaviours Across Pregnant Women and Husbands: An Actor-Partner Interdependence Modelling.", "authors": [{"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Imani", "given": "Vida", "initials": "V"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Timpka", "given": "Toomas", "initials": "T"}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Updegraff", "given": "John A", "initials": "JA"}, {"family": "\u00c5restedt", "given": "Kristofer", "initials": "K"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2020-06-11", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "issn-l": null, "volume": null, "issue": null, "pages": "1-15"}, "abstract": "The present cross-sectional study examined the actor-partner interdependence effect of fear of COVID-19 among Iranian pregnant women and their husbands and its association with their mental health and preventive behaviours during the first wave of the COVID-19 pandemic in 2020. A total of 290 pregnant women and their husbands ( N = 580) were randomly selected from a list of pregnant women in the Iranian Integrated Health System and were invited to respond to psychometric scales assessing fear of COVID-19, depression, anxiety, suicidal intention, mental quality of life, and COVID-19 preventive behaviours. The findings demonstrated significant dyadic relationships between husbands and their pregnant wives' fear of COVID-19, mental health, and preventive behaviours. Pregnant wives' actor effect of fear of COVID-19 was significantly associated with depression, suicidal intention, mental quality of life, and COVID-19 preventive behaviours but not anxiety. Moreover, a husband actor effect of fear of COVID-19 was significantly associated with depression, anxiety, suicidal intention, mental quality of life, and COVID-19 preventive behaviours. Additionally, there were significant partner effects observed for both the pregnant wives and their husbands concerning all outcomes. The present study used a cross-sectional design and so is unable to determine the mechanism or causal ordering of the effects. Also, the data are mainly based on self-reported measures which have some limitations due to its potential for social desirability and recall biases. Based on the findings, couples may benefit from psychoeducation that focuses on the effect of mental health problems on pregnant women and the foetus.", "doi": "10.1007/s11469-020-00340-x", "pmid": "32837427", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "340"}, {"db": "pmc", "key": "PMC7289236"}], "notes": [], "created": "2020-12-07T10:36:04.681Z", "modified": "2021-02-26T08:47:00.131Z"}, {"entity": "publication", "iuid": "80ba3c6566dd4245b48fae35ee04d17a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/80ba3c6566dd4245b48fae35ee04d17a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/80ba3c6566dd4245b48fae35ee04d17a"}}, "title": "Two complementary model-based methods for calculating the risk of international spreading of a novel virus from the outbreak epicentre. The case of COVID-19.", "authors": [{"family": "Massad", "given": "Eduardo", "initials": "E"}, {"family": "Amaku", "given": "Marcos", "initials": "M"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Costa Dos Santos", "given": "Paulo Cesar", "initials": "PC"}, {"family": "Struchiner", "given": "Claudio Jose", "initials": "CJ"}, {"family": "Coutinho", "given": "Francisco Antonio Bezerra", "initials": "FAB"}], "type": "journal article", "published": "2020-06-09", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": "148", "issue": null, "pages": "e109", "issn-l": null}, "abstract": "We present two complementary model-based methods for calculating the risk of international spread of the novel coronavirus SARS-CoV-2 from the outbreak epicentre. One model aims to calculate the number of cases that would be exported from an endemic country to disease-free regions by travellers. The second model calculates the probability that an infected traveller will generate at least one secondary autochthonous case in the visited country. Although this paper focuses on the data from China, our methods can be adapted to calculate the risk of importation and subsequent outbreaks. We found an average R0 = 5.31 (ranging from 4.08 to 7.91) and a risk of spreading of 0.75 latent individuals per 1000 travellers. In addition, one infective traveller would be able to generate at least one secondary autochthonous case in the visited country with a probability of 23%.", "doi": "10.1017/S0950268820001223", "pmid": "32513345", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0950268820001223"}, {"db": "pmc", "key": "PMC7298081"}], "notes": [], "created": "2020-12-09T10:32:44.837Z", "modified": "2021-02-26T08:46:13.339Z"}, {"entity": "publication", "iuid": "bea00c18be9a4b858823b661f7fd1093", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bea00c18be9a4b858823b661f7fd1093.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bea00c18be9a4b858823b661f7fd1093"}}, "title": "Sampling bias and incorrect rooting make phylogenetic network tracing of SARS-COV-2 infections unreliable.", "authors": [{"family": "Mavian", "given": "Carla", "initials": "C", "orcid": "0000-0003-3819-5520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1480d0856ce148d49095321cc9c69977.json"}}, {"family": "Pond", "given": "Sergei Kosakovsky", "initials": "SK"}, {"family": "Marini", "given": "Simone", "initials": "S"}, {"family": "Magalis", "given": "Brittany Rife", "initials": "BR", "orcid": "0000-0001-6088-4651", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13ad1ff37ac54221bf1b1bbd68e37448.json"}}, {"family": "Vandamme", "given": "Anne-Mieke", "initials": "AM"}, {"family": "Dellicour", "given": "Simon", "initials": "S"}, {"family": "Scarpino", "given": "Samuel V", "initials": "SV", "orcid": "0000-0001-5716-2770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90b3b5f60b4745bda076bfa5c36e2201.json"}}, {"family": "Houldcroft", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1833-5285", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1058544bcab84e37b4e9442b80fbd398.json"}}, {"family": "Villabona-Arenas", "given": "Julian", "initials": "J"}, {"family": "Paisie", "given": "Taylor K", "initials": "TK", "orcid": "0000-0002-6024-2744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf0ca78109e2489eb19d25f2bb9d69c2.json"}}, {"family": "Trov\u00e3o", "given": "N\u00eddia S", "initials": "NS", "orcid": "0000-0002-2106-1166", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b13a1d1532074e8c812b4ad41600e17d.json"}}, {"family": "Boucher", "given": "Christina", "initials": "C"}, {"family": "Zhang", "given": "Yun", "initials": "Y"}, {"family": "Scheuermann", "given": "Richard H", "initials": "RH"}, {"family": "Gascuel", "given": "Olivier", "initials": "O"}, {"family": "Lam", "given": "Tommy Tsan-Yuk", "initials": "TT"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Abecasis", "given": "Ana", "initials": "A"}, {"family": "Wilkinson", "given": "Eduan", "initials": "E"}, {"family": "de Oliveira", "given": "Tulio", "initials": "T"}, {"family": "Bento", "given": "Ana I", "initials": "AI", "orcid": "0000-0001-7728-007X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4cc7effceac545aeb92eaa1dd0d8eea3.json"}}, {"family": "Schmidt", "given": "Heiko A", "initials": "HA", "orcid": "0000-0002-2311-8592", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e11b64fb6ed74b50ad88b6d6725c212b.json"}}, {"family": "Martin", "given": "Darren", "initials": "D"}, {"family": "Hadfield", "given": "James", "initials": "J"}, {"family": "Faria", "given": "Nuno", "initials": "N"}, {"family": "Grubaugh", "given": "Nathan D", "initials": "ND"}, {"family": "Neher", "given": "Richard A", "initials": "RA"}, {"family": "Baele", "given": "Guy", "initials": "G", "orcid": "0000-0002-1915-7732", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ed706bd4a744d8da6a2561880e98eba.json"}}, {"family": "Lemey", "given": "Philippe", "initials": "P"}, {"family": "Stadler", "given": "Tanja", "initials": "T"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Crandall", "given": "Keith A", "initials": "KA", "orcid": "0000-0002-0836-3389", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc79bb378b6b473abaa11659ec9620b9.json"}}, {"family": "Leitner", "given": "Thomas", "initials": "T", "orcid": "0000-0001-8160-2588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c26a4f8a2e204bc5930718c55a6d4a25.json"}}, {"family": "Stamatakis", "given": "Alexandros", "initials": "A"}, {"family": "Prosperi", "given": "Mattia", "initials": "M", "orcid": "0000-0002-9021-5595", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73d6b84d966e4738a7ab4556013b3a63.json"}}, {"family": "Salemi", "given": "Marco", "initials": "M"}], "type": "letter", "published": "2020-06-09", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "117", "issue": "23", "pages": "12522-12523", "issn-l": "0027-8424"}, "abstract": "Comment", "doi": "10.1073/pnas.2007295117", "pmid": "32381734", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7293693"}, {"db": "pii", "key": "2007295117"}], "notes": [], "created": "2020-11-25T07:31:25.225Z", "modified": "2023-06-19T15:37:57.813Z"}, {"entity": "publication", "iuid": "ae0bfe026d6d4e9c8821e05c1b33e008", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ae0bfe026d6d4e9c8821e05c1b33e008.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ae0bfe026d6d4e9c8821e05c1b33e008"}}, "title": "Clinical Characteristics of COVID-19 Patients With Gastrointestinal Symptoms: An Analysis of Seven Patients in China.", "authors": [{"family": "Ai", "given": "Jin-Wei", "initials": "JW"}, {"family": "Zi", "given": "Hao", "initials": "H"}, {"family": "Wang", "given": "Yong", "initials": "Y"}, {"family": "Huang", "given": "Qiao", "initials": "Q"}, {"family": "Wang", "given": "Na", "initials": "N"}, {"family": "Li", "given": "Lu-Yao", "initials": "LY"}, {"family": "Pei", "given": "Bin", "initials": "B"}, {"family": "Ji", "given": "Jianguang", "initials": "J"}, {"family": "Zeng", "given": "Xian-Tao", "initials": "XT"}], "type": "journal article", "published": "2020-06-09", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "7", "issue": null, "pages": "308", "issn-l": null}, "abstract": "Objectives: Patients with novel coronavirus disease 2019 (COVID-19) can present with gastrointestinal symptoms as their initial symptoms or as the main manifestations during disease progression, but the clinical characteristics of these patients are still unknown. Methods: We identified COVID-19 patients who admitted to Xiangyang No. 1 People's Hospital and presented with gastrointestinal symptoms as their initial or main symptoms. Their medical records were reviewed by two independent clinical scientists. The epidemiological and clinical characteristics as well as the clinical outcomes were analyzed. Results: Among 142 confirmed COVID-19 cases, 7 (4.9%) of them presented with gastrointestinal symptoms. Three patients had gastrointestinal symptoms as the initial symptoms and chief complaints, and 4 patients as the main symptoms during disease progression. Six patients had symptoms of diarrhea (3-16 days), 7 with anorexia (7-22 days), 6 with upper abdominal discomfort (1-7 days), and 4 with nausea (1-7 days), 1 with heartburn lasting 2 days, and 2 with vomiting symptoms (1 day). The chest CT scan showed typical COVID-19 imaging features, and associated with the progression of the disease. During treatment, 2 patients died due to organ failure. Discussion: COVID-19 patients with gastrointestinal symptoms are relatively rare and might be misdiagnosed. The clinical features include watery stools, anorexia, and upper abdominal discomfort. These patients may have severe disease and be associated with a poor prognosis. The underlying mechanisms of SARS-CoV-2 related gastrointestinal symptoms need to clarify in future studies.", "doi": "10.3389/fmed.2020.00308", "pmid": "32656221", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7325892"}], "notes": [], "created": "2020-12-08T14:15:30.089Z", "modified": "2021-02-26T08:45:48.571Z"}, {"entity": "publication", "iuid": "39cbb22196de4f19883ea00af5966044", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/39cbb22196de4f19883ea00af5966044.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/39cbb22196de4f19883ea00af5966044"}}, "title": "Correction: The challenge of COVID-19 and hematopoietic cell transplantation: EBMT recommendations for management of hematopoietic cell transplant recipients, their donors, and patients undergoing CAR T-cell therapy.", "authors": [{"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Mikulska", "given": "Malgorzata", "initials": "M"}, {"family": "de la Camara", "given": "Rafael", "initials": "R"}, {"family": "Basak", "given": "Grzegorz W", "initials": "GW"}, {"family": "Chabannon", "given": "Christian", "initials": "C"}, {"family": "Corbacioglu", "given": "Selim", "initials": "S"}, {"family": "Duarte", "given": "Rafael", "initials": "R"}, {"family": "Dolstra", "given": "Harry", "initials": "H"}, {"family": "Lankester", "given": "Arjan C", "initials": "AC"}, {"family": "Mohty", "given": "Mohamad", "initials": "M"}, {"family": "Montoto", "given": "Silvia", "initials": "S"}, {"family": "Murray", "given": "John", "initials": "J"}, {"family": "de Latour", "given": "R\u00e9gis Peffault", "initials": "RP"}, {"family": "Snowden", "given": "John A", "initials": "JA"}, {"family": "Yakoub-Agha", "given": "Ibrahim", "initials": "I"}, {"family": "Verhoeven", "given": "Bregje", "initials": "B"}, {"family": "Kr\u00f6ger", "given": "Nicolaus", "initials": "N"}, {"family": "Styczynski", "given": "Jan", "initials": "J"}, {"family": "European Society for Blood and Marrow Transplantation", "given": "", "initials": ""}], "type": "published erratum", "published": "2020-06-08", "journal": {"title": "Bone Marrow Transplant", "issn": "1476-5365", "volume": null, "issue": null, "issn-l": "0268-3369"}, "abstract": "An amendment to this paper has been published and can be accessed via a link at the top of the paper.", "doi": "10.1038/s41409-020-0965-7", "pmid": "32514158", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41409-020-0965-7"}, {"db": "pmc", "key": "PMC7278762"}], "notes": [], "created": "2020-11-25T09:56:54.993Z", "modified": "2020-12-09T10:32:02.389Z"}, {"entity": "publication", "iuid": "112efbced8284cb695c6852237f4b604", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/112efbced8284cb695c6852237f4b604.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/112efbced8284cb695c6852237f4b604"}}, "title": "The influence of the SARS-CoV-2 pandemic on esophagogastric cancer services: an international survey of esophagogastric surgeons.", "authors": [{"family": "Kamarajah", "given": "Sivesh K", "initials": "SK"}, {"family": "Markar", "given": "Sheraz R", "initials": "SR"}, {"family": "Singh", "given": "Pritam", "initials": "P"}, {"family": "Griffiths", "given": "Ewen A", "initials": "EA"}, {"family": "Oesophagogastric Anastomosis Audit Group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-06-05", "journal": {"title": "Dis Esophagus", "issn": "1442-2050", "issn-l": "1120-8694", "volume": null, "issue": null, "pages": null}, "abstract": "Several guidelines to guide clinical practice among esophagogastric surgeons during the COVID-19 pandemic were produced. However, none provide reflection of current service provision. This international survey aimed to clarify the changes observed in esophageal and gastric cancer management and surgery during the COVID-19 pandemic.\r\n\r\nAn online survey covering key areas for esophagogastric cancer services, including staging investigations and oncological and surgical therapy before and during (at two separate time-points-24th March 2020 and 18th April 2020) the COVID-19 pandemic were developed.\r\n\r\nA total of 234 respondents from 225 centers and 49 countries spanning six continents completed the first round of the online survey, of which 79% (n = 184) completed round 2. There was variation in the availability of staging investigations ranging from 26.5% for endoscopic ultrasound to 62.8% for spiral computed tomography scan. Definitive chemoradiotherapy was offered in 14.8% (adenocarcinoma) and 47.0% (squamous cell carcinoma) of respondents and significantly increased by almost three-fold and two-fold, respectively, in both round 1 and 2. There were uncertainty and heterogeneity surrounding prioritization of patients undergoing cancer resections. Of the surgeons symptomatic with COVID-19, only 40.2% (33/82) had routine access to COVID-19 polymerase chain reaction testing for staff. Of those who had testing available (n = 33), only 12.1% (4/33) had tested positive.\r\n\r\nThese data highlight management challenges and several practice variations in caring for patients with esophagogastric cancers. Therefore, there is a need for clear consistent guidelines to be in place in the event of a further pandemic to ensure a standardized level of oncological care for patients with esophagogastric cancers.", "doi": "10.1093/dote/doaa054", "pmid": "32500134", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "5851505"}, {"db": "pmc", "key": "PMC7314222"}], "notes": [], "created": "2020-11-25T09:44:08.645Z", "modified": "2022-11-10T07:53:55.709Z"}, {"entity": "publication", "iuid": "f8d08d0b526240e2b6ab9f13216bea3e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f8d08d0b526240e2b6ab9f13216bea3e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f8d08d0b526240e2b6ab9f13216bea3e"}}, "title": "Severe inflammation in children - cause for awareness during the current pandemic", "authors": [{"family": "Horne", "given": "AnnaCarin", "initials": "A"}, {"family": "Nordenh\u00e4ll", "given": "Lotta", "initials": "L"}], "type": "journal article", "published": "2020-06-05", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": "Clinical manifestations of COVID-19 in children are generally mild and many are asymptomatic. However, recent international reports have described clusters of children presenting with an unusual syndrome of high, persistent fever, severe inflammation and single- or multiorgan dysfunction, with a suspected association to COVID-19 pandemic. It is recommended that clinicians are aware of this rare syndrome and that suspected cases are treated in a multidisciplinary setting.", "doi": null, "pmid": "32542615", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "20094"}], "notes": [], "created": "2020-11-25T10:07:27.646Z", "modified": "2020-12-08T07:19:25.327Z"}, {"entity": "publication", "iuid": "5a3f35577cf0436ea0a28d8f046de55f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5a3f35577cf0436ea0a28d8f046de55f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5a3f35577cf0436ea0a28d8f046de55f"}}, "title": "Changes in Gambling Behavior during the COVID-19 Pandemic-A Web Survey Study in Sweden.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-06-05", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "11", "pages": null}, "abstract": "The COVID-19 pandemic has dramatically changed everyday life, and policy makers have raised concerns about possible changes in gambling patterns during the pandemic. This study aimed to examine whether self-reported gambling has increased during the pandemic, and to examine potential correlates of such a change. This general population survey study in Sweden collected self-report data from 2016 web survey members (51 percent men, nine percent moderate-risk/problem gamblers). Correlates of increased gambling and increased gambling specifically due to COVID-19-related cancellation of sports were calculated. Four percent reported an overall gambling increase during the pandemic. The proportion of individuals reporting an increase, compared to individuals reporting a decrease, was markedly higher for online casinos (0.62), online horse betting (0.76) and online lotteries (0.73), and lower for sports betting (0.11). Overall, gambling increases were independently associated with gambling problems and increased alcohol consumption. In the sub-group, where there was an increase in specific gambling types in response to cancelled sports betting events, rates of gambling problems were high. In conclusion, only a minority report increased gambling in response to the pandemic, but this group has markedly higher gambling problems and changes in alcohol consumption, and may represent a sub-group with a particularly high vulnerability. This calls for preventive action in people with higher gambling risks in response to the pandemic.", "doi": "10.3390/ijerph17114013", "pmid": "32516880", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "ijerph17114013"}, {"db": "pmc", "key": "PMC7312016"}], "notes": [], "created": "2020-12-09T10:30:11.240Z", "modified": "2022-11-10T07:54:17.524Z"}, {"entity": "publication", "iuid": "0be77bad07c449b1adfe016d20bbdcd6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0be77bad07c449b1adfe016d20bbdcd6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0be77bad07c449b1adfe016d20bbdcd6"}}, "title": "Detection of asymptomatic SARS-CoV-2 exposed individuals by a sensitive S-based ELISA", "authors": [{"family": "Rosendal", "given": "Ebba", "initials": "E"}, {"family": "Bystr\u00f6m", "given": "Julia Wigren", "initials": "JW"}, {"family": "Gr\u00f6ning", "given": "Remigius", "initials": "R"}, {"family": "Gwon", "given": "Yong Dae", "initials": "YD"}, {"family": "Nilsson", "given": "Emma", "initials": "E"}, {"family": "Sharma", "given": "Atin", "initials": "A"}, {"family": "Espaillat", "given": "Akbar", "initials": "A"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Thunberg", "given": "Therese", "initials": "T"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Puhar", "given": "Andrea", "initials": "A"}, {"family": "Cava", "given": "Felipe", "initials": "F"}, {"family": "Hedestam", "given": "Gunilla B Karlsson", "initials": "GBK"}, {"family": "Monsen", "given": "Tor", "initials": "T"}, {"family": "Elgh", "given": "Fredrik", "initials": "F"}, {"family": "Blomkvist", "given": "Bert", "initials": "B"}, {"family": "Marklund", "given": "Ingrid", "initials": "I"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Evander", "given": "Magnus", "initials": "M"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Johansson", "given": "Anders", "initials": "A"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "Forsell", "given": "Mattias NE", "initials": "MN", "orcid": "0000-0001-6904-742X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e41c0e1c9c7b499fb3d844d4c572e7bb.json"}}], "type": "posted-content", "published": "2020-06-04", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To assess the current coronavirus pandemic, there is a pressing need to determine the exposure and seroconversion to SARS-CoV-2 on a local and global level. Here, we demonstrate a sensitive and specific S-protein based assay that is well suited for detection of weak SARS- CoV-2-directed IgG responses, and that could identify exposed individuals with asymptomatic infection without the requirement of PCR diagnostics. Our results raise the possibility that on- going population-based studies using less sensitive state-of-the-art serological assays may significantly underestimate the frequency of exposure and seroconversion to SARS-CoV-2.", "doi": "10.1101/2020.06.02.20120477", "pmid": "32577692", "labels": {"Funder: KAW/SciLifeLab": null, "Funder: Vinnova": null, "Type: Preprint": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null, "Research Area: Host cell systems biology and targets": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-04T15:53:34.262Z", "modified": "2021-12-22T13:24:39.638Z"}, {"entity": "publication", "iuid": "4a19975d90fc4ffc8b4111c6836782d2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4a19975d90fc4ffc8b4111c6836782d2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4a19975d90fc4ffc8b4111c6836782d2"}}, "title": "The term \"physical distancing\" is recommended rather than \"social distancing\" during the COVID-19 pandemic for reducing feelings of rejection among people with mental health problems.", "authors": [{"family": "Wasserman", "given": "Danuta", "initials": "D"}, {"family": "van der Gaag", "given": "Rutger", "initials": "R"}, {"family": "Wise", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2020-06-01", "journal": {"title": "Eur Psychiatry", "issn": "1778-3585", "issn-l": "0924-9338", "volume": "63", "issue": "1", "pages": "e52"}, "abstract": "As COVID-19 has plagued our world, the term \"social distancing\" has been widely used with the aim to encourage the general population to physically distance themselves from others in order to reduce the spread of the virus. However, this term can have unintended but detrimental effects, as it evokes negative feelings of being ignored, unwelcome, left alone with one's own fears, and even excluded from society. These feelings may be stronger in people with mental illnesses and in socio-economically disadvantaged groups, such as stigmatized minorities, migrants, and homeless persons [1], many of them also having high risk for suicidal behaviors [2]. Mental health disorders are pervasive worldwide; the global burden accounting for approximately 21.2-32.4% of years lived with disability-more than any other group of illnesses [3]. So, the vulnerable group of people with mental health disorders represents a considerable share of the total global population.", "doi": "10.1192/j.eurpsy.2020.60", "pmid": "32475365", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0924933820000607"}, {"db": "pmc", "key": "PMC7287304"}], "notes": [], "created": "2020-11-25T09:29:57.335Z", "modified": "2022-11-10T07:54:44.175Z"}, {"entity": "publication", "iuid": "c1e74612a5d64ee89229777ca2d62d81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1e74612a5d64ee89229777ca2d62d81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1e74612a5d64ee89229777ca2d62d81"}}, "title": "Recommendations for the management of patients with immune-mediated kidney disease during the severe acute respiratory syndrome coronavirus 2 pandemic.", "authors": [{"family": "Anders", "given": "Hans-Joachim", "initials": "HJ"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Fernandez Juarez", "given": "Gema Maria", "initials": "GM"}, {"family": "Floege", "given": "J\u00fcrgen", "initials": "J"}, {"family": "Goumenos", "given": "Dimitrios", "initials": "D"}, {"family": "Turkmen", "given": "Kultigin", "initials": "K"}, {"family": "van Kooten", "given": "Cees", "initials": "C"}, {"family": "Tesar", "given": "Vladimir", "initials": "V"}, {"family": "Segelmark", "given": "M\u00e5rten", "initials": "M"}], "type": "journal article", "published": "2020-06-01", "journal": {"title": "Nephrol Dial Transplant", "issn": "1460-2385", "volume": "35", "issue": "6", "pages": "920-925", "issn-l": "0931-0509"}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has created major challenges for all countries around the globe. Retrospective studies have identified hypertension, cardiovascular disease, diabetes and older age as risk factors for high morbidity and mortality from COVID-19. There is a general concern that patients with immune-mediated kidney diseases, namely those on immunosuppressive therapies and/or those with more advanced kidney failure, could particularly be at risk for adverse outcomes due to a compromised antiviral immunity. Uncertainties exist on how management routines should be reorganized to minimize the risk of severe acute respiratory syndrome coronavirus 2 infection and what measures are necessary for infected patients. The aim of the present review of the Immunonephrology Working Group of the European Renal Association-European Dialysis and Transplant Association is to provide recommendations for the management of patients with immune-mediated kidney diseases based on the available evidence, similar circumstances with other infectious organisms and expert opinions from across Europe. Such recommendations may help to minimize the risk of encountering COVID-19 or developing complications during COVID-19 in patients with immune-mediated kidney disease.", "doi": "10.1093/ndt/gfaa112", "pmid": "32445573", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "5843427"}, {"db": "pmc", "key": "PMC7313759"}], "notes": [], "created": "2020-11-25T09:12:56.146Z", "modified": "2020-11-30T09:03:28.660Z"}, {"entity": "publication", "iuid": "d056cbfa81d345eb837ec8f343f8a79e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d056cbfa81d345eb837ec8f343f8a79e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d056cbfa81d345eb837ec8f343f8a79e"}}, "title": "Measurement of hydroxychloroquine in blood from SLE patients using LC-HRMS-evaluation of whole blood, plasma, and serum as sample matrices.", "authors": [{"family": "Carlsson", "given": "Henrik", "initials": "H"}, {"family": "Hjorton", "given": "Karin", "initials": "K"}, {"family": "Abujrais", "given": "Sandy", "initials": "S"}, {"family": "R\u00f6nnblom", "given": "Lars", "initials": "L"}, {"family": "\u00c5kerfeldt", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Kultima", "given": "Kim", "initials": "K"}], "type": "journal article", "published": "2020-06-01", "journal": {"title": "Arthritis Res Ther", "issn": "1478-6362", "volume": "22", "issue": "1", "pages": "125", "issn-l": "1478-6354"}, "abstract": "Hydroxychloroquine (HCQ) is the standard of care in the treatment of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and other inflammatory rheumatic diseases and potentially for the treatment in COVID-19 patients. Determination of HCQ for therapeutic drug monitoring (TDM) can be performed in whole blood (WB), serum, and plasma. Direct comparisons of WB, serum, and plasma levels of HCQ in patients with SLE have not previously been reported. We describe a method for the determination of HCQ in human blood using liquid chromatography-high-resolution mass spectrometry (LC-HRMS) and compare the suitability of the three sample matrices.\r\n\r\nA method for the determination of HCQ in human blood using LC-HRMS was developed, validated, and applied for the determination of HCQ levels in WB, serum, and plasma from 26 SLE patients. The reproducibility of the method, in the three matrices, was evaluated using quality control samples and repeated preparations and measurements of patient samples. The performance of the developed method for HCQ measurement in serum was further evaluated by comparison with two previously reported extraction methods.\r\n\r\nThe performance of the presented method demonstrated high accuracy and precision. A large range of HCQ concentrations was observed for the SLE patients in all three matrices (WB, serum, and plasma). The mean levels in WB were approximately two-fold the levels in serum and plasma (813 ng/mL compared to 436 ng/mL and 362 ng/mL, respectively). Spiked quality controls showed high reproducibility for all matrices (coefficient of variation, CV, approx. 5%), whereas in patient samples, equally high-precision was only found using WB as the matrix (CV 3%). The CV for serum and plasma was 14% and 39%, respectively. Two alternative methods applied to serum samples did not demonstrate improved precision.\r\n\r\nA LC-HRMS method for the measurement of HCQ in human blood was developed and validated. Whole blood was found to be the superior sample matrix in terms of sample reproducibility. Thus, whole blood samples should be used for HCQ analysis when patients are monitored for HCQ treatment effects. The assay is in clinical use to monitor levels of HCQ in patients.", "doi": "10.1186/s13075-020-02211-1", "pmid": "32475347", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13075-020-02211-1"}, {"db": "pmc", "key": "PMC7261520"}], "notes": [], "created": "2020-11-19T14:50:28.058Z", "modified": "2021-02-26T08:46:13.524Z"}, {"entity": "publication", "iuid": "9847a5d1a5084ca1b4ae55e88af59985", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9847a5d1a5084ca1b4ae55e88af59985.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9847a5d1a5084ca1b4ae55e88af59985"}}, "title": "Covid-19 - radiologic and histologic features", "authors": [{"family": "Mari Svensson", "given": "Ann", "initials": "A"}, {"family": "Hansen", "given": "Tomas", "initials": "T"}, {"family": "Nyren", "given": "Sven", "initials": "S"}, {"family": "Csatl\u00f3s", "given": "Martin", "initials": "M"}, {"family": "Brunnstr\u00f6m", "given": "Hans", "initials": "H"}], "type": "journal article", "published": "2020-06-01", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": "We here describe the current knowledge about the radiologic and histologic pulmonary features of covid-19, caused by SARS-CoV-2, and present lung histology from a case with fatal disease. Initial findings on computed tomography (CT) typically include peripheral multifocal bilateral ground-glass opacities, and correspondingly microscopic alveolar edema. This is followed by peripheral consolidations with air bronchogram and perilobular pattern on CT, signs of organizing pneumonia, corresponding to loose (potentially reversible) fibrosis. The posterior parts of the lungs and the lower lobes are typically more markedly affected. In severe disease with acute respiratory distress syndrome, thickened interlobular septa and crazy paving pattern appear on CT, which corresponds to histologic diffuse alveolar damage with, depending on the stage of the disease, features such as edema, hyaline membranes, reactive epithelium, inflammation, and fibrosis.", "doi": null, "pmid": "32484232", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "20086"}], "notes": [], "created": "2020-11-22T08:44:16.883Z", "modified": "2021-02-26T08:45:48.489Z"}, {"entity": "publication", "iuid": "e2b308acfdcf4885acf82db9e0f2c298", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2b308acfdcf4885acf82db9e0f2c298.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2b308acfdcf4885acf82db9e0f2c298"}}, "title": "[Covid-19: An ad hoc public health ethics consultation].", "authors": [{"family": "Wild", "given": "Verina", "initials": "V"}, {"family": "Buyx", "given": "Alena", "initials": "A"}, {"family": "Hurst", "given": "Samia", "initials": "S"}, {"family": "Munthe", "given": "Christian", "initials": "C"}, {"family": "Rid", "given": "Annette", "initials": "A"}, {"family": "Schr\u00f6der-B\u00e4ck", "given": "Peter", "initials": "P"}, {"family": "Strech", "given": "Daniel", "initials": "D"}, {"family": "Thompson", "given": "Alison", "initials": "A"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Gesundheitswesen", "issn": "1439-4421", "volume": "82", "issue": "6", "pages": "507-513", "issn-l": null}, "abstract": "In this paper we describe the process and content of our ad hoc public health ethics consultation for a Bavarian health authority in relation to Covid-19.", "doi": "10.1055/a-1174-0086", "pmid": "32604443", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7365938"}], "notes": [], "created": "2020-12-08T15:24:01.743Z", "modified": "2020-12-08T15:24:01.765Z"}, {"entity": "publication", "iuid": "793041f844bb47a6b0459f63b5bf4649", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/793041f844bb47a6b0459f63b5bf4649.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/793041f844bb47a6b0459f63b5bf4649"}}, "title": "Why is COVID-19 so mild in children?", "authors": [{"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}], "type": "editorial", "published": "2020-06-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": "109", "issue": "6", "pages": "1082-1083"}, "abstract": "Editorial", "doi": "10.1111/apa.15271", "pmid": "32212348", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-04T15:21:26.972Z", "modified": "2021-07-14T07:51:13.276Z"}, {"entity": "publication", "iuid": "f07fdb27688443f7a55e2521ea4aa933", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f07fdb27688443f7a55e2521ea4aa933.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f07fdb27688443f7a55e2521ea4aa933"}}, "title": "The importance of naturally attenuated SARS-CoV-2in the fight against COVID-19.", "authors": [{"family": "Armengaud", "given": "Jean", "initials": "J"}, {"family": "Delaunay-Moisan", "given": "Agn\u00e8s", "initials": "A"}, {"family": "Thuret", "given": "Jean-Yves", "initials": "JY"}, {"family": "van Anken", "given": "Eelco", "initials": "E"}, {"family": "Acosta-Alvear", "given": "Diego", "initials": "D"}, {"family": "Arag\u00f3n", "given": "Tom\u00e1s", "initials": "T"}, {"family": "Arias", "given": "Carolina", "initials": "C"}, {"family": "Blondel", "given": "Marc", "initials": "M"}, {"family": "Braakman", "given": "Ineke", "initials": "I"}, {"family": "Collet", "given": "Jean-Fran\u00e7ois", "initials": "JF"}, {"family": "Courcol", "given": "Ren\u00e9", "initials": "R"}, {"family": "Danchin", "given": "Antoine", "initials": "A"}, {"family": "Deleuze", "given": "Jean-Fran\u00e7ois", "initials": "JF"}, {"family": "Lavigne", "given": "Jean-Philippe", "initials": "JP"}, {"family": "Lucas", "given": "Sophie", "initials": "S"}, {"family": "Michiels", "given": "Thomas", "initials": "T"}, {"family": "Moore", "given": "Edward R B", "initials": "ERB"}, {"family": "Nixon-Abell", "given": "Jonathon", "initials": "J"}, {"family": "Rossello-Mora", "given": "Ramon", "initials": "R"}, {"family": "Shi", "given": "Zheng-Li", "initials": "ZL"}, {"family": "Siccardi", "given": "Antonio G", "initials": "AG"}, {"family": "Sitia", "given": "Roberto", "initials": "R"}, {"family": "Tillett", "given": "Daniel", "initials": "D"}, {"family": "Timmis", "given": "Kenneth N", "initials": "KN"}, {"family": "Toledano", "given": "Michel B", "initials": "MB"}, {"family": "van der Sluijs", "given": "Peter", "initials": "P"}, {"family": "Vicenzi", "given": "Elisa", "initials": "E"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Environ Microbiol", "issn": "1462-2920", "volume": "22", "issue": "6", "pages": "1997-2000", "issn-l": null}, "abstract": "The current SARS-CoV-2 pandemic is wreaking havoc throughout the world and has rapidly become a global health emergency. A central question concerning COVID-19 is why some individuals become sick and others not. Many have pointed already at variation in risk factors between individuals. However, the variable outcome of SARS-CoV-2 infections may, at least in part, be due also to differences between the viral subspecies with which individuals are infected. A more pertinent question is how we are to overcome the current pandemic. A vaccine against SARS-CoV-2 would offer significant relief, although vaccine developers have warned that design, testing and production of vaccines may take a year if not longer. Vaccines are based on a handful of different designs (i), but the earliest vaccines were based on the live, attenuated virus. As has been the case for other viruses during earlier pandemics, SARS-CoV-2 will mutate and may naturally attenuate over time (ii). What makes the current pandemic unique is that, thanks to state-of-the-art nucleic acid sequencing technologies, we can follow in detail how SARS-CoV-2 evolves while it spreads. We argue that knowledge of naturally emerging attenuated SARS-CoV-2 variants across the globe should be of key interest in our fight against the pandemic.", "doi": "10.1111/1462-2920.15039", "pmid": "32342578", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7267670"}], "notes": [], "created": "2020-12-10T07:13:58.995Z", "modified": "2020-12-10T07:14:16.138Z"}, {"entity": "publication", "iuid": "bc62516c1ade4b42900f062d118bf82a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bc62516c1ade4b42900f062d118bf82a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bc62516c1ade4b42900f062d118bf82a"}}, "title": "The disproportionate effect of COVID-19 mortality on ethnic minorities: Genetics or health inequalities?", "authors": [{"family": "El-Khatib", "given": "Ziad", "initials": "Z"}, {"family": "Jacobs", "given": "Graeme Brendon", "initials": "GB"}, {"family": "Ikomey", "given": "George Mondinde", "initials": "GM"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": "23", "issue": null, "pages": "100430", "issn-l": null}, "abstract": null, "doi": "10.1016/j.eclinm.2020.100430", "pmid": "32572393", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(20)30174-7"}, {"db": "pii", "key": "100430"}, {"db": "pmc", "key": "PMC7301807"}], "notes": [], "created": "2020-12-08T16:25:48.111Z", "modified": "2020-12-08T16:25:48.121Z"}, {"entity": "publication", "iuid": "65fdc6954fee4cacbb4b1282ea71421b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65fdc6954fee4cacbb4b1282ea71421b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65fdc6954fee4cacbb4b1282ea71421b"}}, "title": "The consequences of the COVID-19 pandemic for self-care in patients supported with a left ventricular assist device.", "authors": [{"family": "Ben Gal", "given": "Tuvia", "initials": "T"}, {"family": "Ben Avraham", "given": "Binyamin", "initials": "B"}, {"family": "Abu-Hazira", "given": "Miriam", "initials": "M"}, {"family": "Frigerio", "given": "Maria", "initials": "M"}, {"family": "Crespo-Leiro", "given": "Maria G", "initials": "MG"}, {"family": "Oppelaar", "given": "Anne Marie", "initials": "AM"}, {"family": "Kato", "given": "Naoko P", "initials": "NP"}, {"family": "Stromberg", "given": "Anna", "initials": "A"}, {"family": "Jaarsma", "given": "Tiny", "initials": "T"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Eur J Heart Fail", "issn": "1879-0844", "volume": "22", "issue": "6", "pages": "933-936", "issn-l": "1388-9842"}, "abstract": null, "doi": "10.1002/ejhf.1868", "pmid": "32391963", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7273102"}], "notes": [], "created": "2020-11-30T09:07:59.472Z", "modified": "2020-11-30T09:07:59.482Z"}, {"entity": "publication", "iuid": "30730f9295124a0ebe25fa06dd1e672e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/30730f9295124a0ebe25fa06dd1e672e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/30730f9295124a0ebe25fa06dd1e672e"}}, "title": "The Role of Pharmacovigilance and ISoP During the Global COVID-19 Pandemic.", "authors": [{"family": "Chandler", "given": "Rebecca E", "initials": "RE"}, {"family": "McCarthy", "given": "Deirdre", "initials": "D"}, {"family": "Delumeau", "given": "Jean-Christophe", "initials": "JC"}, {"family": "Harrison-Woolrych", "given": "Mira", "initials": "M"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Drug Saf", "issn": "1179-1942", "volume": "43", "issue": "6", "pages": "511-512", "issn-l": "0114-5916"}, "abstract": null, "doi": "10.1007/s40264-020-00941-4", "pmid": "32383008", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40264-020-00941-4"}, {"db": "pmc", "key": "PMC7203700"}], "notes": [], "created": "2020-12-10T07:39:37.185Z", "modified": "2020-12-10T07:44:48.952Z"}, {"entity": "publication", "iuid": "c1839231ec1844ed9ef55d3dc7eaf2fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1839231ec1844ed9ef55d3dc7eaf2fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1839231ec1844ed9ef55d3dc7eaf2fa"}}, "title": "Tackling two pandemics: a plea on World Tuberculosis Day.", "authors": [{"family": "Wingfield", "given": "Tom", "initials": "T"}, {"family": "Cuevas", "given": "Luis E", "initials": "LE"}, {"family": "MacPherson", "given": "Peter", "initials": "P"}, {"family": "Millington", "given": "Kerry A", "initials": "KA"}, {"family": "Squire", "given": "S Bertel", "initials": "SB"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "volume": "8", "issue": "6", "pages": "536-538", "issn-l": "2213-2600"}, "abstract": null, "doi": "10.1016/S2213-2600(20)30151-X", "pmid": "32220280", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(20)30151-X"}, {"db": "pmc", "key": "PMC7118542"}], "notes": [], "created": "2020-11-25T07:24:34.379Z", "modified": "2020-12-08T06:57:33.234Z"}, {"entity": "publication", "iuid": "8483b981df644399a2b16f6c0c276fa1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8483b981df644399a2b16f6c0c276fa1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8483b981df644399a2b16f6c0c276fa1"}}, "title": "Systematic review of COVID\u201019 in children shows milder cases and a better prognosis than adults", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "journal-article", "published": "2020-06-00", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "volume": "109", "issue": "6", "pages": "1088-1095", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has affected hundreds of thousands of people. Data on symptoms and prognosis in children are rare.\n\nA systematic literature review was carried out to identify papers on COVID-19, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), using the MEDLINE and Embase databases between January 1 and March 18, 2020.\n\nThe search identified 45 relevant scientific papers and letters. The review showed that children have so far accounted for 1%-5% of diagnosed COVID-19 cases, they often have milder disease than adults and deaths have been extremely rare. Diagnostic findings have been similar to adults, with fever and respiratory symptoms being prevalent, but fewer children seem to have developed severe pneumonia. Elevated inflammatory markers were less common in children, and lymphocytopenia seemed rare. Newborn infants have developed symptomatic COVID-19, but evidence of vertical intrauterine transmission was scarce. Suggested treatment included providing oxygen, inhalations, nutritional support and maintaining fluids and electrolyte balances.\n\nThe coronavirus disease 2019 has occurred in children, but they seemed to have a milder disease course and better prognosis than adults. Deaths were extremely rare.", "doi": "10.1111/apa.15270", "pmid": "32202343", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-04T13:20:33.860Z", "modified": "2020-12-10T09:00:20.059Z"}, {"entity": "publication", "iuid": "88f3f44ed037429b84b2679f50149fb2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/88f3f44ed037429b84b2679f50149fb2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/88f3f44ed037429b84b2679f50149fb2"}}, "title": "Surveillance to improve evidence for community control decisions during the COVID-19 pandemic - Opening the animal epidemic toolbox for Public Health.", "authors": [{"family": "Foddai", "given": "Alessandro", "initials": "A"}, {"family": "Lindberg", "given": "Ann", "initials": "A"}, {"family": "Lubroth", "given": "Juan", "initials": "J"}, {"family": "Ellis-Iversen", "given": "Johanne", "initials": "J"}], "type": "editorial", "published": "2020-06-00", "journal": {"title": "One Health", "issn": "2352-7714", "volume": "9", "issue": null, "pages": "100130", "issn-l": "2352-7714"}, "abstract": "During the first few months of 2020, the COVID-19 pandemic reached Europe and spread around the world. Health systems all over the world are trying to control the outbreak in the shortest possible time. Exotic disease outbreaks are not uncommon in animal health and randomised surveillance is frequently used as support for decision-making. This editorial discusses the possibilities of practicing One Health, by using methods from animal health to enhance surveillance for COVID-19 to provide an evidence base fort decision-making in communities and countries.", "doi": "10.1016/j.onehlt.2020.100130", "pmid": "32292816", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2352-7714(20)30046-X"}, {"db": "pii", "key": "100130"}, {"db": "pmc", "key": "PMC7104048"}], "notes": [], "created": "2020-12-09T12:07:55.701Z", "modified": "2020-12-09T12:07:55.711Z"}, {"entity": "publication", "iuid": "d3ccd047985d4acb94bac604fe32433c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3ccd047985d4acb94bac604fe32433c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3ccd047985d4acb94bac604fe32433c"}}, "title": "Sleep apnoea management in Europe during the COVID-19 pandemic: data from the European Sleep Apnoea Database (ESADA).", "authors": [{"family": "Grote", "given": "Ludger", "initials": "L"}, {"family": "McNicholas", "given": "Walter T", "initials": "WT"}, {"family": "Hedner", "given": "Jan", "initials": "J"}, {"family": "ESADA collaborators", "given": "", "initials": ""}], "type": "letter", "published": "2020-06-00", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "issn-l": "0903-1936", "volume": "55", "issue": "6", "pages": null}, "abstract": null, "doi": "10.1183/13993003.01323-2020", "pmid": "32366489", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "13993003.01323-2020"}, {"db": "pmc", "key": "PMC7236823"}], "notes": [], "created": "2020-12-10T07:27:06.019Z", "modified": "2022-11-10T07:57:10.670Z"}, {"entity": "publication", "iuid": "84d70442f23c48c0bd1adaf3746235fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84d70442f23c48c0bd1adaf3746235fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84d70442f23c48c0bd1adaf3746235fa"}}, "title": "Promoting healthy movement behaviours among children during the COVID-19 pandemic.", "authors": [{"family": "Guan", "given": "Hongyan", "initials": "H"}, {"family": "Okely", "given": "Anthony D", "initials": "AD"}, {"family": "Aguilar-Farias", "given": "Nicolas", "initials": "N"}, {"family": "Del Pozo Cruz", "given": "Borja", "initials": "B"}, {"family": "Draper", "given": "Catherine E", "initials": "CE"}, {"family": "El Hamdouchi", "given": "Asmaa", "initials": "A"}, {"family": "Florindo", "given": "Alex A", "initials": "AA"}, {"family": "J\u00e1uregui", "given": "Alejandra", "initials": "A"}, {"family": "Katzmarzyk", "given": "Peter T", "initials": "PT"}, {"family": "Kontsevaya", "given": "Anna", "initials": "A"}, {"family": "L\u00f6f", "given": "Marie", "initials": "M"}, {"family": "Park", "given": "Wonsoon", "initials": "W"}, {"family": "Reilly", "given": "John J", "initials": "JJ"}, {"family": "Sharma", "given": "Deepika", "initials": "D"}, {"family": "Tremblay", "given": "Mark S", "initials": "MS"}, {"family": "Veldman", "given": "Sanne L C", "initials": "SLC"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Lancet Child Adolesc Health", "issn": "2352-4650", "volume": "4", "issue": "6", "pages": "416-418", "issn-l": null}, "abstract": null, "doi": "10.1016/S2352-4642(20)30131-0", "pmid": "32458805", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2352-4642(20)30131-0"}, {"db": "pmc", "key": "PMC7190292"}], "notes": [], "created": "2020-12-09T11:04:29.834Z", "modified": "2020-12-09T11:04:29.857Z"}, {"entity": "publication", "iuid": "82eecfee1dc44f1384c78e45611f490c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82eecfee1dc44f1384c78e45611f490c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82eecfee1dc44f1384c78e45611f490c"}}, "title": "Population flow drives spatio-temporal distribution of COVID-19 in China.", "authors": [{"family": "Jia", "given": "Jayson S", "initials": "JS"}, {"family": "Lu", "given": "Xin", "initials": "X"}, {"family": "Yuan", "given": "Yun", "initials": "Y"}, {"family": "Xu", "given": "Ge", "initials": "G"}, {"family": "Jia", "given": "Jianmin", "initials": "J"}, {"family": "Christakis", "given": "Nicholas A", "initials": "NA"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "582", "issue": "7812", "pages": "389-394", "issn-l": "0028-0836"}, "abstract": "Sudden, large-scale and diffuse human migration can amplify localized outbreaks of disease into widespread epidemics 1-4. Rapid and accurate tracking of aggregate population flows may therefore be epidemiologically informative. Here we use 11,478,484 counts of mobile phone data from individuals leaving or transiting through the prefecture of Wuhan between 1 January and 24 January 2020 as they moved to 296 prefectures throughout mainland China. First, we document the efficacy of quarantine in ceasing movement. Second, we show that the distribution of population outflow from Wuhan accurately predicts the relative frequency and geographical distribution of infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) until 19 February 2020, across mainland China. Third, we develop a spatio-temporal 'risk source' model that leverages population flow data (which operationalize the risk that emanates from epidemic epicentres) not only to forecast the distribution of confirmed cases, but also to identify regions that have a high risk of transmission at an early stage. Fourth, we use this risk source model to statistically derive the geographical spread of COVID-19 and the growth pattern based on the population outflow from Wuhan; the model yields a benchmark trend and an index for assessing the risk of community transmission of COVID-19 over time for different locations. This approach can be used by policy-makers in any nation with available data to make rapid and accurate risk assessments and to plan the allocation of limited resources ahead of ongoing outbreaks.", "doi": "10.1038/s41586-020-2284-y", "pmid": "32349120", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://static-content.springer.com/esm/art%3A10.1038%2Fs41586-020-2284-y/MediaObjects/41586_2020_2284_MOESM3_ESM.xlsx", "description": "Population outflow data from Wuhan from January 1-24, 2020; COVID-19 case counts as of February 19 and other data for 296 prefectures in mainland China"}], "notes": [], "created": "2020-11-25T07:14:25.611Z", "modified": "2021-02-26T08:45:48.422Z"}, {"entity": "publication", "iuid": "035950dd9daf476c8b949f168f529119", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/035950dd9daf476c8b949f168f529119.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/035950dd9daf476c8b949f168f529119"}}, "title": "Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science.", "authors": [{"family": "Holmes", "given": "Emily A", "initials": "EA"}, {"family": "O'Connor", "given": "Rory C", "initials": "RC"}, {"family": "Perry", "given": "V Hugh", "initials": "VH"}, {"family": "Tracey", "given": "Irene", "initials": "I"}, {"family": "Wessely", "given": "Simon", "initials": "S"}, {"family": "Arseneault", "given": "Louise", "initials": "L"}, {"family": "Ballard", "given": "Clive", "initials": "C"}, {"family": "Christensen", "given": "Helen", "initials": "H"}, {"family": "Cohen Silver", "given": "Roxane", "initials": "R"}, {"family": "Everall", "given": "Ian", "initials": "I"}, {"family": "Ford", "given": "Tamsin", "initials": "T"}, {"family": "John", "given": "Ann", "initials": "A"}, {"family": "Kabir", "given": "Thomas", "initials": "T"}, {"family": "King", "given": "Kate", "initials": "K"}, {"family": "Madan", "given": "Ira", "initials": "I"}, {"family": "Michie", "given": "Susan", "initials": "S"}, {"family": "Przybylski", "given": "Andrew K", "initials": "AK"}, {"family": "Shafran", "given": "Roz", "initials": "R"}, {"family": "Sweeney", "given": "Angela", "initials": "A"}, {"family": "Worthman", "given": "Carol M", "initials": "CM"}, {"family": "Yardley", "given": "Lucy", "initials": "L"}, {"family": "Cowan", "given": "Katherine", "initials": "K"}, {"family": "Cope", "given": "Claire", "initials": "C"}, {"family": "Hotopf", "given": "Matthew", "initials": "M"}, {"family": "Bullmore", "given": "Ed", "initials": "E"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Lancet Psychiatry", "issn": "2215-0374", "volume": "7", "issue": "6", "pages": "547-560", "issn-l": "2215-0366"}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic is having a profound effect on all aspects of society, including mental health and physical health. We explore the psychological, social, and neuroscientific effects of COVID-19 and set out the immediate priorities and longer-term strategies for mental health science research. These priorities were informed by surveys of the public and an expert panel convened by the UK Academy of Medical Sciences and the mental health research charity, MQ: Transforming Mental Health, in the first weeks of the pandemic in the UK in March, 2020. We urge UK research funding agencies to work with researchers, people with lived experience, and others to establish a high level coordination group to ensure that these research priorities are addressed, and to allow new ones to be identified over time. The need to maintain high-quality research standards is imperative. International collaboration and a global perspective will be beneficial. An immediate priority is collecting high-quality data on the mental health effects of the COVID-19 pandemic across the whole population and vulnerable groups, and on brain function, cognition, and mental health of patients with COVID-19. There is an urgent need for research to address how mental health consequences for vulnerable groups can be mitigated under pandemic conditions, and on the impact of repeated media consumption and health messaging around COVID-19. Discovery, evaluation, and refinement of mechanistically driven interventions to address the psychological, social, and neuroscientific aspects of the pandemic are required. Rising to this challenge will require integration across disciplines and sectors, and should be done together with people with lived experience. New funding will be required to meet these priorities, and it can be efficiently leveraged by the UK's world-leading infrastructure. This Position Paper provides a strategy that may be both adapted for, and integrated with, research efforts in other countries.", "doi": "10.1016/S2215-0366(20)30168-1", "pmid": "32304649", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2215-0366(20)30168-1"}, {"db": "pmc", "key": "PMC7159850"}], "notes": [], "created": "2020-11-25T07:16:12.163Z", "modified": "2020-12-09T14:50:53.491Z"}, {"entity": "publication", "iuid": "e92ee2ee22ad4a6182b9acf7f3d86bee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e92ee2ee22ad4a6182b9acf7f3d86bee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e92ee2ee22ad4a6182b9acf7f3d86bee"}}, "title": "Infection prevention guidelines and considerations for paediatric risk groups when reopening primary schools during COVID-19 pandemic, Norway, April 2020.", "authors": [{"family": "Johansen", "given": "Tone Bjordal", "initials": "TB"}, {"family": "Astrup", "given": "Elisabeth", "initials": "E"}, {"family": "Jore", "given": "Solveig", "initials": "S"}, {"family": "Nilssen", "given": "Hege", "initials": "H"}, {"family": "Dahlberg", "given": "Bente Barton", "initials": "BB"}, {"family": "Klingenberg", "given": "Claus", "initials": "C"}, {"family": "Berg", "given": "Are Stuwitz", "initials": "AS"}, {"family": "Greve-Isdahl", "given": "Margrethe", "initials": "M"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "22", "issn-l": null}, "abstract": "In response to the coronavirus disease (COVID-19) pandemic, most countries implemented school closures. In Norway, schools closed on 13 March 2020. The evidence of effect on disease transmission was limited, while negative consequences were evident. Before reopening, risk-assessment for paediatric risk groups was performed, concluding that most children can attend school with few conditions requiring preventative homeschooling. We here present infection prevention and control guidelines for primary schools and recommendations for paediatric risk groups.", "doi": "10.2807/1560-7917.ES.2020.25.22.2000921", "pmid": "32524956", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7336110"}], "notes": [], "created": "2020-12-09T10:08:03.231Z", "modified": "2020-12-09T10:08:17.584Z"}, {"entity": "publication", "iuid": "b9f3736061384153b2c37590835ae09f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9f3736061384153b2c37590835ae09f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9f3736061384153b2c37590835ae09f"}}, "title": "Increased importance of digital medicine and eHealth during the Covid-19 pandemic.", "authors": [{"family": "Thulesius", "given": "Hans", "initials": "H"}], "type": "editorial", "published": "2020-06-00", "journal": {"title": "Scand J Prim Health Care", "issn": "1502-7724", "volume": "38", "issue": "2", "pages": "105-106", "issn-l": null}, "abstract": null, "doi": "10.1080/02813432.2020.1770466", "pmid": "32484725", "labels": {"Type: Other": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-09T10:54:36.128Z", "modified": "2021-02-26T08:45:48.615Z"}, {"entity": "publication", "iuid": "29f2b116641f4317b6d80f5bda3097b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/29f2b116641f4317b6d80f5bda3097b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/29f2b116641f4317b6d80f5bda3097b3"}}, "title": "Income security during public health emergencies: the COVID-19 poverty trap in Vietnam.", "authors": [{"family": "Tran", "given": "Phuong Bich", "initials": "PB"}, {"family": "Hensing", "given": "Gunnel", "initials": "G"}, {"family": "Wingfield", "given": "Tom", "initials": "T"}, {"family": "Atkins", "given": "Salla", "initials": "S"}, {"family": "Sidney Annerstedt", "given": "Kristi", "initials": "K"}, {"family": "Kazibwe", "given": "Joseph", "initials": "J"}, {"family": "Tomeny", "given": "Ewan", "initials": "E"}, {"family": "Biermann", "given": "Olivia", "initials": "O"}, {"family": "Thorpe", "given": "Jennifer", "initials": "J"}, {"family": "Forse", "given": "Rachel", "initials": "R"}, {"family": "L\u00f6nnroth", "given": "Knut", "initials": "K"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "5", "issue": "6", "pages": null, "issn-l": "2059-7908"}, "abstract": "Commentary", "doi": "10.1136/bmjgh-2020-002504", "pmid": "32540965", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-002504"}, {"db": "pmc", "key": "PMC7299029"}], "notes": [], "created": "2020-11-25T10:05:13.301Z", "modified": "2020-12-09T07:54:40.461Z"}, {"entity": "publication", "iuid": "958ff2339c9349c9adebb50b167376fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/958ff2339c9349c9adebb50b167376fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/958ff2339c9349c9adebb50b167376fa"}}, "title": "Income security during periods of ill health: a scoping review of policies, practice and coverage in low-income and middle-income countries.", "authors": [{"family": "Thorpe", "given": "Jennifer", "initials": "J"}, {"family": "Viney", "given": "Kerri", "initials": "K"}, {"family": "Hensing", "given": "Gunnel", "initials": "G"}, {"family": "L\u00f6nnroth", "given": "Knut", "initials": "K"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "5", "issue": "6", "issn-l": "2059-7908"}, "abstract": "The COVID-19 pandemic is a reminder that insufficient income security in periods of ill health leads to economic hardship for individuals and hampers disease control efforts as people struggle to stay home when sick or advised to observe quarantine. Evidence on income security during periods of ill health is growing but has not previously been reviewed as a full body of work concerning low-income and middle-income countries (LMICs). We performed a scoping review to map the range, features, coverage, protective effects and equity of policies that aim to provide income security for adults whose ill health prevents them from participating in gainful work. A total of 134 studies were included, providing data from 95% of LMICs. However, data across the majority of these countries were severely limited. Collectively the included studies demonstrate that coverage of contributory income-security schemes is low, especially for informal and low-income workers. Meanwhile, non-contributory schemes targeting low-income groups are often not explicitly designed to provide income support in periods of ill health, they can be difficult to access and rarely provide sufficient income support to cover the needs of eligible recipients. While identifying an urgent need for more research on illness-related income security in LMICs, this review concludes that scaling up and diversifying the range of income security interventions is crucial for improving coverage and equity. To achieve these outcomes, illness-related income protection must receive greater recognition in health policy and health financing circles, expanding our understanding of financial hardship beyond direct medical costs.", "doi": "10.1136/bmjgh-2020-002425", "pmid": "32540963", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-002425"}, {"db": "pmc", "key": "PMC7299014"}], "notes": [], "created": "2020-11-25T10:01:53.442Z", "modified": "2020-11-30T08:59:22.813Z"}, {"entity": "publication", "iuid": "601676ec450744c9b10e81a53394376d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/601676ec450744c9b10e81a53394376d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/601676ec450744c9b10e81a53394376d"}}, "title": "ISUOG Safety Committee Position Statement on use of personal protective equipment and hazard mitigation in relation to SARS-CoV-2 for practitioners undertaking obstetric and gynecological ultrasound.", "authors": [{"family": "Abramowicz", "given": "J S", "initials": "JS"}, {"family": "Basseal", "given": "J M", "initials": "JM"}, {"family": "Brezinka", "given": "C", "initials": "C"}, {"family": "Dall'Asta", "given": "A", "initials": "A"}, {"family": "Deng", "given": "J", "initials": "J"}, {"family": "Harrison", "given": "G", "initials": "G"}, {"family": "Lee", "given": "J C S", "initials": "JCS"}, {"family": "Lim", "given": "A", "initials": "A"}, {"family": "Mar\u0161al", "given": "K", "initials": "K"}, {"family": "Miloro", "given": "P", "initials": "P"}, {"family": "Poon", "given": "L C", "initials": "LC"}, {"family": "Salvesen", "given": "K \u00c5", "initials": "K\u00c5"}, {"family": "Sande", "given": "R", "initials": "R"}, {"family": "Ter Haar", "given": "G", "initials": "G"}, {"family": "Westerway", "given": "S C", "initials": "SC"}, {"family": "Xie", "given": "M X", "initials": "MX"}, {"family": "Lees", "given": "C", "initials": "C"}], "type": "consensus development conference", "published": "2020-06-00", "journal": {"title": "Ultrasound Obstet Gynecol", "issn": "1469-0705", "volume": "55", "issue": "6", "pages": "886-891", "issn-l": null}, "abstract": null, "doi": "10.1002/uog.22035", "pmid": "32255535", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7262197"}], "notes": [], "created": "2020-11-30T15:55:40.240Z", "modified": "2020-11-30T15:55:40.263Z"}, {"entity": "publication", "iuid": "1e769a312b144bada7f7438a482e40e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1e769a312b144bada7f7438a482e40e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1e769a312b144bada7f7438a482e40e2"}}, "title": "High impact of COVID-19 in long-term care facilities, suggestion for monitoring in the EU/EEA, May 2020.", "authors": [{"family": "ECDC Public Health Emergency Team", "given": "", "initials": ""}, {"family": "Danis", "given": "Kostas", "initials": "K"}, {"family": "Fonteneau", "given": "Laure", "initials": "L"}, {"family": "Georges", "given": "Scarlett", "initials": "S"}, {"family": "Daniau", "given": "C\u00f4me", "initials": "C"}, {"family": "Bernard-Stoecklin", "given": "Sibylle", "initials": "S"}, {"family": "Domegan", "given": "Lisa", "initials": "L"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}, {"family": "Hauge", "given": "Siri Helene", "initials": "SH"}, {"family": "Dequeker", "given": "Sara", "initials": "S"}, {"family": "Vandael", "given": "Eline", "initials": "E"}, {"family": "Van der Heyden", "given": "Johan", "initials": "J"}, {"family": "Renard", "given": "Fran\u00e7oise", "initials": "F"}, {"family": "Sierra", "given": "Natalia Bustos", "initials": "NB"}, {"family": "Ricchizzi", "given": "Enrico", "initials": "E"}, {"family": "Schweickert", "given": "Birgitta", "initials": "B"}, {"family": "Schmidt", "given": "Nicole", "initials": "N"}, {"family": "Abu Sin", "given": "Muna", "initials": "M"}, {"family": "Eckmanns", "given": "Tim", "initials": "T"}, {"family": "Paiva", "given": "Jos\u00e9-Artur", "initials": "JA"}, {"family": "Schneider", "given": "Elke", "initials": "E"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "22", "issn-l": null}, "abstract": "Residents in long-term care facilities (LTCF) are a vulnerable population group. Coronavirus disease (COVID-19)-related deaths in LTCF residents represent 30-60% of all COVID-19 deaths in many European countries. This situation demands that countries implement local and national testing, infection prevention and control, and monitoring programmes for COVID-19 in LTCF in order to identify clusters early, decrease the spread within and between facilities and reduce the size and severity of outbreaks.", "doi": "10.2807/1560-7917.ES.2020.25.22.2000956", "pmid": "32524949", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7336111"}], "notes": [], "created": "2020-12-09T10:08:38.057Z", "modified": "2020-12-09T10:08:38.067Z"}, {"entity": "publication", "iuid": "d0916465c57c4e368de76469fa6306d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d0916465c57c4e368de76469fa6306d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d0916465c57c4e368de76469fa6306d0"}}, "title": "Guidance for anti-VEGF intravitreal injections during the COVID-19 pandemic.", "authors": [{"family": "Korobelnik", "given": "Jean-Fran\u00e7ois", "initials": "JF"}, {"family": "Loewenstein", "given": "Anat", "initials": "A"}, {"family": "Eldem", "given": "Bora", "initials": "B"}, {"family": "Joussen", "given": "Antonia M", "initials": "AM"}, {"family": "Koh", "given": "Adrian", "initials": "A"}, {"family": "Lambrou", "given": "George N", "initials": "GN"}, {"family": "Lanzetta", "given": "Paolo", "initials": "P"}, {"family": "Li", "given": "Xiaoxin", "initials": "X"}, {"family": "L\u00f6vestam-Adrian", "given": "Monica", "initials": "M"}, {"family": "Navarro", "given": "Rafael", "initials": "R"}, {"family": "Okada", "given": "Annabelle A", "initials": "AA"}, {"family": "Pearce", "given": "Ian", "initials": "I"}, {"family": "Rodr\u00edguez", "given": "Francisco J", "initials": "FJ"}, {"family": "Wong", "given": "David T", "initials": "DT"}, {"family": "Wu", "given": "Lihteh", "initials": "L"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Graefes Arch Clin Exp Ophthalmol", "issn": "1435-702X", "volume": "258", "issue": "6", "pages": "1149-1156", "issn-l": null}, "abstract": "There is an urgent need to address how to best provide ophthalmic care for patients with retinal disease receiving intravitreal injections with anti-vascular endothelial growth factor agents during the ongoing global COVID-19 pandemic. This article provides guidance for ophthalmologists on how to deliver the best possible care for patients while minimizing the risk of infection.\n\nThe Vision Academy's Steering Committee of international retinal disease experts convened to discuss key considerations for managing patients with retinal disease during the COVID-19 pandemic. After reviewing the existing literature on the issue, members put forward recommendations that were systematically refined and voted on to develop this guidance.\n\nThe considerations focus on the implementation of steps to minimize the exposure of patients and healthcare staff to COVID-19. These include the use of personal protective equipment, adherence to scrupulous hygiene and disinfection protocols, pre-screening to identify symptomatic patients, and reducing the number of people in waiting rooms. Other important measures include triaging of patients to identify those at the greatest risk of irreversible vision loss and prioritization of treatment visits over monitoring visits where possible. In order to limit patient exposure, ophthalmologists should refrain from using treatment regimens that require frequent monitoring.\n\nManagement of patients with retinal disease receiving intravitreal injections during the COVID-19 pandemic will require adjustment to regular clinical practice to minimize the risk of exposure of patients and healthcare staff, and to prioritize those with the greatest medical need. The safety of patients and healthcare staff should be of paramount importance in all decision-making.", "doi": "10.1007/s00417-020-04703-x", "pmid": "32328757", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00417-020-04703-x"}, {"db": "pmc", "key": "PMC7179379"}], "notes": [], "created": "2020-11-30T15:53:13.584Z", "modified": "2020-11-30T15:53:13.608Z"}, {"entity": "publication", "iuid": "091411a45b3043e18f286c3dd9386cab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/091411a45b3043e18f286c3dd9386cab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/091411a45b3043e18f286c3dd9386cab"}}, "title": "From SARS to COVID-19: A previously unknown SARS- related coronavirus (SARS-CoV-2) of pandemic potential infecting humans - Call for a One Health approach.", "authors": [{"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "One Health", "issn": "2352-7714", "volume": "9", "issue": null, "pages": "100124", "issn-l": "2352-7714"}, "abstract": "Human coronaviruses continue to pose a threat to human health. The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019 which causes coronavirus disease-2019 (COVID-19), an acute respiratory disease marked the third introduction of a highly pathogenic coronavirus into the human population in the twenty-first century. This recent emergence of a previously unknown coronavirus in China leads to huge impacts on humans globally. Covid-19 is a challenge to global public health. Here, we discuss the COVID-19 outbreak in a one health context, highlighting the need for the implementation of one health measures and practices to improve human health and reduce the emergence of pandemic viruses.", "doi": "10.1016/j.onehlt.2020.100124", "pmid": "32195311", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2352-7714(20)30013-6"}, {"db": "pii", "key": "100124"}, {"db": "pmc", "key": "PMC7075990"}], "notes": [], "created": "2020-11-19T14:15:33.908Z", "modified": "2020-12-10T09:03:56.468Z"}, {"entity": "publication", "iuid": "7d9967664a4443e28cf52c8f6bf32d7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d9967664a4443e28cf52c8f6bf32d7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d9967664a4443e28cf52c8f6bf32d7a"}}, "title": "Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment.", "authors": [{"family": "Hrusak", "given": "Ondrej", "initials": "O"}, {"family": "Kalina", "given": "Tomas", "initials": "T"}, {"family": "Wolf", "given": "Joshua", "initials": "J"}, {"family": "Balduzzi", "given": "Adriana", "initials": "A"}, {"family": "Provenzi", "given": "Massimo", "initials": "M"}, {"family": "Rizzari", "given": "Carmelo", "initials": "C"}, {"family": "Rives", "given": "Susana", "initials": "S"}, {"family": "Del Pozo Carlavilla", "given": "Mar\u00eda", "initials": "M"}, {"family": "Alonso", "given": "Maria E V", "initials": "MEV"}, {"family": "Dom\u00ednguez-Pinilla", "given": "Nerea", "initials": "N"}, {"family": "Bourquin", "given": "Jean-Pierre", "initials": "JP"}, {"family": "Schmiegelow", "given": "Kjeld", "initials": "K"}, {"family": "Attarbaschi", "given": "Andishe", "initials": "A"}, {"family": "Grillner", "given": "Pernilla", "initials": "P"}, {"family": "Mellgren", "given": "Karin", "initials": "K"}, {"family": "van der Werff Ten Bosch", "given": "Jutte", "initials": "J"}, {"family": "Pieters", "given": "Rob", "initials": "R"}, {"family": "Brozou", "given": "Triantafyllia", "initials": "T"}, {"family": "Borkhardt", "given": "Arndt", "initials": "A"}, {"family": "Escherich", "given": "Gabriele", "initials": "G"}, {"family": "Lauten", "given": "Melchior", "initials": "M"}, {"family": "Stanulla", "given": "Martin", "initials": "M"}, {"family": "Smith", "given": "Owen", "initials": "O"}, {"family": "Yeoh", "given": "Allen E J", "initials": "AEJ"}, {"family": "Elitzur", "given": "Sarah", "initials": "S"}, {"family": "Vora", "given": "Ajay", "initials": "A"}, {"family": "Li", "given": "Chi-Kong", "initials": "CK"}, {"family": "Ariffin", "given": "Hany", "initials": "H"}, {"family": "Kolenova", "given": "Alexandra", "initials": "A"}, {"family": "Dallapozza", "given": "Luciano", "initials": "L"}, {"family": "Farah", "given": "Roula", "initials": "R"}, {"family": "Lazic", "given": "Jelena", "initials": "J"}, {"family": "Manabe", "given": "Atsushi", "initials": "A"}, {"family": "Styczynski", "given": "Jan", "initials": "J"}, {"family": "Kovacs", "given": "Gabor", "initials": "G"}, {"family": "Ottoffy", "given": "Gabor", "initials": "G"}, {"family": "Felice", "given": "Maria S", "initials": "MS"}, {"family": "Buldini", "given": "Barbara", "initials": "B"}, {"family": "Conter", "given": "Valentino", "initials": "V"}, {"family": "Stary", "given": "Jan", "initials": "J"}, {"family": "Schrappe", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Eur J Cancer", "issn": "1879-0852", "volume": "132", "issue": null, "pages": "11-16", "issn-l": "0959-8049"}, "abstract": "Since the beginning of COVID-19 pandemic, it is known that the severe course of the disease occurs mostly among the elderly, whereas it is rare among children and young adults. Comorbidities, in particular, diabetes and hypertension, clearly associated with age, besides obesity and smoke, are strongly associated with the need for intensive treatment and a dismal outcome. A weaker immunity of the elderly has been proposed as a possible explanation of this uneven age distribution. Thus, there is concern that children treated for cancer may allso be at risk for an unfavourable course of infection. Along the same line, anecdotal information from Wuhan, China, mentioned a severe course of COVID-19 in a child treated for leukaemia.\n\nWe made a flash survey on COVID-19 incidence and severity among children on anticancer treatment. Respondents were asked by email to fill in a short Web-based survey.\n\nWe received reports from 25 countries, where approximately 10,000 patients at risk are followed up. At the time of the survey, more than 200 of these children were tested, nine of whom were positive for COVID-19. Eight of the nine cases had asymptomatic to mild disease, and one was just diagnosed with COVID-19. We also discuss preventive measures that are in place or should be taken and treatment options in immunocompromised children with COVID-19.\n\nThus, even children receiving anticancer chemotherapy may have a mild or asymptomatic course of COVID-19. While we should not underestimate the risk of developing a more severe course of COVID-19 than that observed here, the intensity of preventive measures should not cause delays or obstructions in oncological treatment.", "doi": "10.1016/j.ejca.2020.03.021", "pmid": "32305831", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0959-8049(20)30162-3"}, {"db": "pmc", "key": "PMC7141482"}], "notes": [], "created": "2020-11-23T11:40:21.856Z", "modified": "2020-12-09T14:50:34.476Z"}, {"entity": "publication", "iuid": "8380e9f6f24d407083dc596516f81b09", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8380e9f6f24d407083dc596516f81b09.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8380e9f6f24d407083dc596516f81b09"}}, "title": "Festina lente: hydroxychloroquine, COVID-19 and the role of the rheumatologist.", "authors": [{"family": "Graef", "given": "Elizabeth R", "initials": "ER"}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Putman", "given": "Michael S", "initials": "MS"}, {"family": "Simard", "given": "Julia F", "initials": "JF"}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Berenbaum", "given": "Francis", "initials": "F"}, {"family": "Duarte-Garc\u00eda", "given": "Al\u00ed", "initials": "A"}, {"family": "Grainger", "given": "Rebecca", "initials": "R"}, {"family": "Harrison", "given": "Carly", "initials": "C"}, {"family": "Konig", "given": "Maximilian F", "initials": "MF"}, {"family": "Korsten", "given": "Peter", "initials": "P"}, {"family": "Proulx", "given": "Laurie", "initials": "L"}, {"family": "Richards", "given": "Dawn P", "initials": "DP"}, {"family": "Robinson", "given": "Philip C", "initials": "PC"}, {"family": "Sattui", "given": "Sebastian E", "initials": "SE"}, {"family": "Ugarte-Gil", "given": "Manuel Francisco", "initials": "MF"}, {"family": "Young", "given": "Kristen J", "initials": "KJ"}, {"family": "Kim", "given": "Alfred Hj", "initials": "AH"}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA"}, {"family": "COVID-19 Global Rheumatology Alliance", "given": "", "initials": ""}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Ann Rheum Dis", "issn": "1468-2060", "volume": "79", "issue": "6", "pages": "734-736", "issn-l": null}, "abstract": null, "doi": "10.1136/annrheumdis-2020-217480", "pmid": "32295786", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "annrheumdis-2020-217480"}, {"db": "pmc", "key": "PMC7359879"}, {"db": "mid", "key": "NIHMS1606969"}], "notes": [], "created": "2020-11-30T15:55:37.866Z", "modified": "2020-11-30T15:55:37.889Z"}, {"entity": "publication", "iuid": "c3cc1bf8901d417ba85873a09063b21e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3cc1bf8901d417ba85873a09063b21e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3cc1bf8901d417ba85873a09063b21e"}}, "title": "European Task Force on Atopic Dermatitis statement on severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection and atopic dermatitis.", "authors": [{"family": "Wollenberg", "given": "A", "initials": "A"}, {"family": "Flohr", "given": "C", "initials": "C"}, {"family": "Simon", "given": "D", "initials": "D"}, {"family": "Cork", "given": "M J", "initials": "MJ"}, {"family": "Thyssen", "given": "J P", "initials": "JP"}, {"family": "Bieber", "given": "T", "initials": "T"}, {"family": "de Bruin-Weller", "given": "M S", "initials": "MS"}, {"family": "Weidinger", "given": "S", "initials": "S"}, {"family": "Deleuran", "given": "M", "initials": "M"}, {"family": "Taieb", "given": "A", "initials": "A"}, {"family": "Paul", "given": "C", "initials": "C"}, {"family": "Trzeciak", "given": "M", "initials": "M"}, {"family": "Werfel", "given": "T", "initials": "T"}, {"family": "Seneschal", "given": "J", "initials": "J"}, {"family": "Barbarot", "given": "S", "initials": "S"}, {"family": "Darsow", "given": "U", "initials": "U"}, {"family": "Torrelo", "given": "A", "initials": "A"}, {"family": "Stalder", "given": "J-F", "initials": "JF"}, {"family": "Svensson", "given": "\u00c5", "initials": "\u00c5"}, {"family": "Hijnen", "given": "D", "initials": "D"}, {"family": "Gelmetti", "given": "C", "initials": "C"}, {"family": "Szalai", "given": "Z", "initials": "Z"}, {"family": "Gieler", "given": "U", "initials": "U"}, {"family": "De Raeve", "given": "L", "initials": "L"}, {"family": "Kunz", "given": "B", "initials": "B"}, {"family": "Spuls", "given": "P", "initials": "P"}, {"family": "von Kobyletzki", "given": "L B", "initials": "LB"}, {"family": "F\u00f6lster-Holst", "given": "R", "initials": "R"}, {"family": "Chernyshov", "given": "P V", "initials": "PV"}, {"family": "Christen-Zaech", "given": "S", "initials": "S"}, {"family": "Heratizadeh", "given": "A", "initials": "A"}, {"family": "Ring", "given": "J", "initials": "J"}, {"family": "Vestergaard", "given": "C", "initials": "C"}], "type": "letter", "published": "2020-06-00", "journal": {"title": "J Eur Acad Dermatol Venereol", "issn": "1468-3083", "volume": "34", "issue": "6", "pages": "e241-e242", "issn-l": null}, "abstract": null, "doi": "10.1111/jdv.16411", "pmid": "32223003", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-30T16:01:49.309Z", "modified": "2020-12-08T06:58:52.882Z"}, {"entity": "publication", "iuid": "f5f143610ed24ce6b388a493421004cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f5f143610ed24ce6b388a493421004cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f5f143610ed24ce6b388a493421004cc"}}, "title": "European Society of Minimally Invasive Neurological Therapy (ESMINT) recommendations for optimal interventional neurovascular management in the COVID-19 era.", "authors": [{"family": "Aggour", "given": "Mohamed", "initials": "M"}, {"family": "White", "given": "Phil", "initials": "P"}, {"family": "Kulcsar", "given": "Zsolt", "initials": "Z"}, {"family": "Fiehler", "given": "Jens", "initials": "J"}, {"family": "Brouwer", "given": "Patrick", "initials": "P"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "J Neurointerv Surg", "issn": "1759-8486", "volume": "12", "issue": "6", "pages": "542-544", "issn-l": "1759-8478"}, "abstract": null, "doi": "10.1136/neurintsurg-2020-016137", "pmid": "32303584", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "neurintsurg-2020-016137"}], "notes": [], "created": "2020-11-23T11:37:35.344Z", "modified": "2020-11-30T15:55:36.757Z"}, {"entity": "publication", "iuid": "11edc1b3690e4b4389108f054457a93d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/11edc1b3690e4b4389108f054457a93d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/11edc1b3690e4b4389108f054457a93d"}}, "title": "Drought and COVID-19 in the Eastern Mediterranean Region of the WHO.", "authors": [{"family": "Bellizzi", "given": "S", "initials": "S"}, {"family": "Panu Napodano", "given": "C M", "initials": "CM"}, {"family": "Fiamma", "given": "M", "initials": "M"}, {"family": "Ali Maher", "given": "O", "initials": "O"}], "type": "letter", "published": "2020-06-00", "journal": {"title": "Public Health", "issn": "1476-5616", "volume": "183", "issue": null, "pages": "46-47", "issn-l": null}, "abstract": null, "doi": "10.1016/j.puhe.2020.04.032", "pmid": "32422440", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0033-3506(20)30137-2"}, {"db": "pmc", "key": "PMC7205725"}], "notes": [], "created": "2020-12-09T11:45:41.328Z", "modified": "2020-12-09T11:45:41.338Z"}, {"entity": "publication", "iuid": "c39d8c784a284e0a9e934ca3053fcca1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c39d8c784a284e0a9e934ca3053fcca1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c39d8c784a284e0a9e934ca3053fcca1"}}, "title": "Diagnostic and digital solutions to address the COVID-19 pandemic: The need for international collaboration to close the gap.", "authors": [{"family": "Kyhlstedt", "given": "Mattias", "initials": "M"}, {"family": "Andersson", "given": "Sarah Wamala", "initials": "SW"}], "type": "editorial", "published": "2020-06-00", "journal": {"title": "Health Policy Technol", "issn": "2211-8837", "volume": "9", "issue": "2", "pages": "126-128", "issn-l": null}, "abstract": null, "doi": "10.1016/j.hlpt.2020.04.010", "pmid": "32341908", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2211-8837(20)30045-9"}, {"db": "pmc", "key": "PMC7182749"}], "notes": [], "created": "2020-12-10T07:11:46.097Z", "modified": "2020-12-10T07:12:14.626Z"}, {"entity": "publication", "iuid": "3395e910fcf34fa895cd0fc21ca7741d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3395e910fcf34fa895cd0fc21ca7741d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3395e910fcf34fa895cd0fc21ca7741d"}}, "title": "Chronic Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers Is High Among Intensive Care Unit Patients With Non-COVID-19 Sepsis but Carries a Moderately Increased Risk of Death.", "authors": [{"family": "Sunden-Cullberg", "given": "Jonas", "initials": "J"}], "type": "letter", "published": "2020-06-00", "journal": {"title": "Hypertension", "issn": "1524-4563", "volume": "75", "issue": "6", "pages": "e15-e16", "issn-l": "0194-911X"}, "abstract": "Comment", "doi": "10.1161/HYPERTENSIONAHA.120.15178", "pmid": "32275190", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7188028"}], "notes": [], "created": "2020-11-23T11:26:27.056Z", "modified": "2020-12-09T12:06:04.563Z"}, {"entity": "publication", "iuid": "fa6f8658e56447dd96deb89d7f60a796", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa6f8658e56447dd96deb89d7f60a796.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa6f8658e56447dd96deb89d7f60a796"}}, "title": "COVID-19 pandemic: Effects and evidence-based recommendations for otolaryngology and head and neck surgery practice.", "authors": [{"family": "Kowalski", "given": "Luiz P", "initials": "LP"}, {"family": "Sanabria", "given": "Alvaro", "initials": "A"}, {"family": "Ridge", "given": "John A", "initials": "JA"}, {"family": "Ng", "given": "Wai Tong", "initials": "WT"}, {"family": "de Bree", "given": "Remco", "initials": "R"}, {"family": "Rinaldo", "given": "Alessandra", "initials": "A"}, {"family": "Takes", "given": "Robert P", "initials": "RP"}, {"family": "M\u00e4kitie", "given": "Antti A", "initials": "AA"}, {"family": "Carvalho", "given": "Andre L", "initials": "AL"}, {"family": "Bradford", "given": "Carol R", "initials": "CR"}, {"family": "Paleri", "given": "Vinidh", "initials": "V"}, {"family": "Hartl", "given": "Dana M", "initials": "DM"}, {"family": "Vander Poorten", "given": "Vincent", "initials": "V"}, {"family": "Nixon", "given": "Iain J", "initials": "IJ"}, {"family": "Piazza", "given": "Cesare", "initials": "C"}, {"family": "Lacy", "given": "Peter D", "initials": "PD"}, {"family": "Rodrigo", "given": "Juan P", "initials": "JP"}, {"family": "Guntinas-Lichius", "given": "Orlando", "initials": "O"}, {"family": "Mendenhall", "given": "William M", "initials": "WM"}, {"family": "D'Cruz", "given": "Anil", "initials": "A"}, {"family": "Lee", "given": "Anne W M", "initials": "AWM"}, {"family": "Ferlito", "given": "Alfio", "initials": "A"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Head Neck", "issn": "1097-0347", "volume": "42", "issue": "6", "pages": "1259-1267", "issn-l": "1043-3074"}, "abstract": "The 2019 novel coronavirus disease (COVID-19) is a highly contagious zoonosis produced by SARS-CoV-2 that is spread human-to-human by respiratory secretions. It was declared by the WHO as a public health emergency. The most susceptible populations, needing mechanical ventilation, are the elderly and people with associated comorbidities. There is an important risk of contagion for anesthetists, dentists, head and neck surgeons, maxillofacial surgeons, ophthalmologists, and otolaryngologists. Health workers represent between 3.8% and 20% of the infected population; some 15% will develop severe complaints and among them, many will lose their lives. A large number of patients do not have overt signs and symptoms (fever/respiratory), yet pose a real risk to surgeons (who should know this fact and must therefore apply respiratory protective strategies for all patients they encounter). All interventions that have the potential to aerosolize aerodigestive secretions should be avoided or used only when mandatory. Health workers who are: pregnant, over 55 to 65 years of age, with a history of chronic diseases (uncontrolled hypertension, diabetes mellitus, chronic obstructive pulmonary diseases, and all clinical scenarios where immunosuppression is feasible, including that induced to treat chronic inflammatory conditions and organ transplants) should avoid the clinical attention of a potentially infected patient. Health care facilities should prioritize urgent and emergency visits and procedures until the present condition stabilizes; truly elective care should cease and discussed on a case-by-case basis for patients with cancer. For those who are working with COVID-19 infected patients' isolation is compulsory in the following settings: (a) unprotected close contact with COVID-19 pneumonia patients; (b) onset of fever, cough, shortness of breath, and other symptoms (gastrointestinal complaints, anosmia, and dysgeusia have been reported in a minority of cases). For any care or intervention in the upper aerodigestive tract region, irrespective of the setting and a confirmed diagnosis (eg, rhinoscopy or flexible laryngoscopy in the outpatient setting and tracheostomy or rigid endoscopy under anesthesia), it is strongly recommended that all health care personnel wear personal protective equipment such as N95, gown, cap, eye protection, and gloves. The procedures described are essential in trying to maintain safety of health care workers during COVID-19 pandemic. In particular, otolaryngologists, head and neck, and maxillofacial surgeons are per se exposed to the greatest risk of infection while caring for COVID-19 positive subjects, and their protection should be considered a priority in the present circumstances.", "doi": "10.1002/hed.26164", "pmid": "32270581", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7262203"}], "notes": [], "created": "2020-11-22T17:13:43.745Z", "modified": "2021-02-26T08:45:48.906Z"}, {"entity": "publication", "iuid": "53949d8569d644fea43526782295763e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53949d8569d644fea43526782295763e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53949d8569d644fea43526782295763e"}}, "title": "COVID-19 and urology: a comprehensive review of the literature.", "authors": [{"family": "Puliatti", "given": "Stefano", "initials": "S"}, {"family": "Eissa", "given": "Ahmed", "initials": "A"}, {"family": "Eissa", "given": "Radwa", "initials": "R"}, {"family": "Amato", "given": "Marco", "initials": "M"}, {"family": "Mazzone", "given": "Elio", "initials": "E"}, {"family": "Dell'Oglio", "given": "Paolo", "initials": "P"}, {"family": "Sighinolfi", "given": "Maria Chiara", "initials": "MC"}, {"family": "Zoeir", "given": "Ahmed", "initials": "A"}, {"family": "Micali", "given": "Salvatore", "initials": "S"}, {"family": "Bianchi", "given": "Giampaolo", "initials": "G"}, {"family": "Patel", "given": "Vipul", "initials": "V"}, {"family": "Wiklund", "given": "Peter", "initials": "P"}, {"family": "Coelho", "given": "Rafael F", "initials": "RF"}, {"family": "Bernhard", "given": "Jean-Christophe", "initials": "JC"}, {"family": "Dasgupta", "given": "Prokar", "initials": "P"}, {"family": "Mottrie", "given": "Alexandre", "initials": "A"}, {"family": "Rocco", "given": "Bernardo", "initials": "B"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "BJU Int", "issn": "1464-410X", "volume": "125", "issue": "6", "pages": "E7-E14", "issn-l": "1464-4096"}, "abstract": "To discuss the impact of COVID-19 on global health, particularly on urological practice and to review some of the available recommendations reported in the literature.\n\nIn the current narrative review the PubMed database was searched to identify all the related reports discussing the impact of COVID-19 on the urological field.\n\nThe COVID-19 pandemic is the latest and biggest global health threat. Medical and surgical priorities have changed dramatically to cope with the current challenge. These changes include postponements of all elective outpatient visits and surgical procedures to save facilities and resources for urgent cases and patients with COVID-19 patients. This review discuss some of the related changes in urology.\n\nOver the coming weeks, healthcare workers including urologists will be facing increasingly difficult challenges, and consequently, they should adopt triage strategy to avoid wasting of medical resources and they should endorse sufficient protection policies to guard against infection when dealing with COVID-19 patients.", "doi": "10.1111/bju.15071", "pmid": "32249538", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-22T17:05:52.843Z", "modified": "2020-12-09T11:49:47.884Z"}, {"entity": "publication", "iuid": "26126d85d88b4bfbb806f5648b298c2b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26126d85d88b4bfbb806f5648b298c2b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26126d85d88b4bfbb806f5648b298c2b"}}, "title": "COVID-19 and the policy sciences: initial reactions and perspectives", "authors": [{"family": "Weible", "given": "Christopher M", "initials": "CM"}, {"family": "Nohrstedt", "given": "Daniel", "initials": "D"}, {"family": "Cairney", "given": "Paul", "initials": "P"}, {"family": "Carter", "given": "David P", "initials": "DP"}, {"family": "Crow", "given": "Deserai A", "initials": "DA"}, {"family": "Durnov\u00e1", "given": "Anna P", "initials": "AP"}, {"family": "Heikkila", "given": "Tanya", "initials": "T"}, {"family": "Ingold", "given": "Karin", "initials": "K"}, {"family": "McConnell", "given": "Allan", "initials": "A"}, {"family": "Stone", "given": "Diane", "initials": "D"}], "type": "journal-article", "published": "2020-06-00", "journal": {"title": "Policy Sci", "issn": "0032-2687", "volume": "53", "issue": "2", "pages": "225-241", "issn-l": null}, "abstract": "The world is in the grip of a crisis that stands unprecedented in living memory. The COVID-19 pandemic is urgent, global in scale, and massive in impacts. Following Harold D. Lasswell's goal for the policy sciences to offer insights into unfolding phenomena, this commentary draws on the lessons of the policy sciences literature to understand the dynamics related to COVID-19. We explore the ways in which scientific and technical expertise, emotions, and narratives influence policy decisions and shape relationships among citizens, organizations, and governments. We discuss varied processes of adaptation and change, including learning, surges in policy responses, alterations in networks (locally and globally), implementing policies across transboundary issues, and assessing policy success and failure. We conclude by identifying understudied aspects of the policy sciences that deserve attention in the pandemic's aftermath.", "doi": "10.1007/s11077-020-09381-4", "pmid": "32313308", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "9381"}, {"db": "pmc", "key": "PMC7165254"}], "notes": [], "created": "2020-12-09T14:51:20.654Z", "modified": "2021-12-06T12:55:45.743Z"}, {"entity": "publication", "iuid": "e3b44608bd1a49b48f775d1281f565e6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3b44608bd1a49b48f775d1281f565e6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3b44608bd1a49b48f775d1281f565e6"}}, "title": "A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection", "authors": [{"family": "Casanova", "given": "Jean Laurent", "initials": "JL"}, {"family": "Su", "given": "Helen C", "initials": "HC"}, {"family": "Abel", "given": "Laurent", "initials": "L"}, {"family": "Aiuti", "given": "Alessandro", "initials": "A"}, {"family": "Almuhsen", "given": "Saleh", "initials": "S"}, {"family": "Arias", "given": "Andres Augusto", "initials": "AA"}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Biggs", "given": "Catherine", "initials": "C"}, {"family": "Bogunovic", "given": "Dusan", "initials": "D"}, {"family": "Boisson", "given": "Bertrand", "initials": "B"}, {"family": "Boisson-Dupuis", "given": "Stephanie", "initials": "S"}, {"family": "Bolze", "given": "Alexandre", "initials": "A"}, {"family": "Bondarenko", "given": "Anastasia", "initials": "A"}, {"family": "Bousfiha", "given": "Aziz", "initials": "A"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "Bustamante", "given": "Jacinta", "initials": "J"}, {"family": "Butte", "given": "Manish", "initials": "M"}, {"family": "Casari", "given": "Giorgio", "initials": "G"}, {"family": "Ciancanelli", "given": "Michael", "initials": "M"}, {"family": "Cobat", "given": "Aurelie", "initials": "A"}, {"family": "Condino-Neto", "given": "Antonio", "initials": "A"}, {"family": "Cooper", "given": "Megan", "initials": "M"}, {"family": "Dalgard", "given": "Clifton", "initials": "C"}, {"family": "Espinosa", "given": "Sara", "initials": "S"}, {"family": "Feldman", "given": "Hagit", "initials": "H"}, {"family": "Fellay", "given": "Jacques", "initials": "J"}, {"family": "Franco", "given": "Jose Luis", "initials": "JL"}, {"family": "Hagin", "given": "David", "initials": "D"}, {"family": "Itan", "given": "Yuval", "initials": "Y"}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E"}, {"family": "Lucas", "given": "Carrie", "initials": "C"}, {"family": "Mansouri", "given": "Davood", "initials": "D"}, {"family": "Meyts", "given": "Isabelle", "initials": "I"}, {"family": "Milner", "given": "Joshua", "initials": "J"}, {"family": "Mogensen", "given": "Trine", "initials": "T"}, {"family": "Morio", "given": "Tomohiro", "initials": "T"}, {"family": "Ng", "given": "Lisa", "initials": "L"}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD"}, {"family": "Okada", "given": "Satoshi", "initials": "S"}, {"family": "Ozcelik", "given": "Tayfun", "initials": "T"}, {"family": "Soler Palac\u00edn", "given": "Pere", "initials": "P"}, {"family": "Planas", "given": "Anna", "initials": "A"}, {"family": "Prando", "given": "Carolina", "initials": "C"}, {"family": "Puel", "given": "Anne", "initials": "A"}, {"family": "Pujol", "given": "Aurora", "initials": "A"}, {"family": "Redin", "given": "Claire", "initials": "C"}, {"family": "Renia", "given": "Laurent", "initials": "L"}, {"family": "Rodriguez Gallego", "given": "Jose Carlos", "initials": "JC"}, {"family": "Quintana-Murci", "given": "Lluis", "initials": "L"}, {"family": "Sancho-Shimizu", "given": "Vanessa", "initials": "V"}, {"family": "Sankaran", "given": "Vijay", "initials": "V"}, {"family": "Sepp\u00e4nen", "given": "Mikko R J", "initials": "MRJ"}, {"family": "Shahrooei", "given": "Mohammad", "initials": "M"}, {"family": "Snow", "given": "Andrew", "initials": "A"}, {"family": "Spaan", "given": "Andr\u00e1s", "initials": "A"}, {"family": "Tangye", "given": "Stuart", "initials": "S"}, {"family": "Tur", "given": "Jordi Perez", "initials": "JP"}, {"family": "Turvey", "given": "Stuart", "initials": "S"}, {"family": "Vinh", "given": "Donald C", "initials": "DC"}, {"family": "von Bernuth", "given": "Horst", "initials": "H"}, {"family": "Wang", "given": "Xiaochuan", "initials": "X"}, {"family": "Zawadzki", "given": "Pawel", "initials": "P"}, {"family": "Zhang", "given": "Qian", "initials": "Q"}, {"family": "Zhang", "given": "Shenying", "initials": "S"}], "type": "journal-article", "published": "2020-06-00", "journal": {"title": "Cell", "issn": "0092-8674", "issn-l": null, "volume": "181", "issue": "6", "pages": "1194-1199"}, "abstract": null, "doi": "10.1016/j.cell.2020.05.016", "pmid": null, "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [], "notes": [], "created": "2021-01-08T14:42:51.655Z", "modified": "2021-02-26T08:45:14.484Z"}, {"entity": "publication", "iuid": "c1a203b527b147eb9c8b072439cb950d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1a203b527b147eb9c8b072439cb950d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1a203b527b147eb9c8b072439cb950d"}}, "title": "COVID-19 Pandemic: What Can the West Learn From the East?", "authors": [{"family": "Shokoohi", "given": "Mostafa", "initials": "M"}, {"family": "Osooli", "given": "Mehdi", "initials": "M"}, {"family": "Stranges", "given": "Saverio", "initials": "S"}], "type": "journal article", "published": "2020-05-31", "journal": {"title": "Int J Health Policy Manag", "issn": "2322-5939", "volume": null, "issue": null, "issn-l": null}, "abstract": "Differences in public health approaches to control the coronavirus disease 2019 (COVID-19) pandemic could largely explain substantial variations in epidemiological indicators (such as incidence and mortality) between the West and the East. COVID-19 revealed vulnerabilities of most western countries' healthcare systems in their response to the ongoing public health crisis. Hence, western countries can possibly learn from practices from several East Asian countries regarding infrastructures, epidemiological surveillance and control strategies to mitigate the public health impact of the pandemic. In this paper, we discuss that the lack of rapid and timely community-centered approaches, and most importantly weak public health infrastructures, might have resulted in a high number of infected cases and fatalities in many western countries.", "doi": "10.34172/ijhpm.2020.85", "pmid": "32610736", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-08T15:21:17.919Z", "modified": "2020-12-08T15:21:17.941Z"}, {"entity": "publication", "iuid": "2d3174860b5c42748add3b95c71de385", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d3174860b5c42748add3b95c71de385.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d3174860b5c42748add3b95c71de385"}}, "title": "The invisible pandemic.", "authors": [{"family": "Giesecke", "given": "Johan", "initials": "J"}], "type": "letter", "published": "2020-05-30", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "395", "issue": "10238", "pages": "e98", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)31035-7", "pmid": "32539940", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31035-7"}, {"db": "pmc", "key": "PMC7200128"}], "notes": [], "created": "2020-11-25T10:01:09.416Z", "modified": "2020-12-09T07:55:20.718Z"}, {"entity": "publication", "iuid": "f7811fd8913f43e78c16e387fc37e5f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7811fd8913f43e78c16e387fc37e5f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7811fd8913f43e78c16e387fc37e5f0"}}, "title": "Low prevalence of SARS-CoV-2 among pregnant and postpartum patients with universal screening in Seattle, Washington.", "authors": [{"family": "LaCourse", "given": "Sylvia M", "initials": "SM"}, {"family": "Kachikis", "given": "Alisa", "initials": "A"}, {"family": "Blain", "given": "Michela", "initials": "M"}, {"family": "Simmons", "given": "LaVone E", "initials": "LE"}, {"family": "Mays", "given": "James A", "initials": "JA"}, {"family": "Pattison", "given": "Amber D", "initials": "AD"}, {"family": "Salerno", "given": "Carol C", "initials": "CC"}, {"family": "McCartney", "given": "Stephen A", "initials": "SA"}, {"family": "Kretzer", "given": "Nicole M", "initials": "NM"}, {"family": "Resnick", "given": "Rebecca", "initials": "R"}, {"family": "Shay", "given": "Rosemary L", "initials": "RL"}, {"family": "Savitsky", "given": "Leah M", "initials": "LM"}, {"family": "Curtin", "given": "Anna C", "initials": "AC"}, {"family": "Huebner", "given": "Emily M", "initials": "EM"}, {"family": "Ma", "given": "Kimberly K", "initials": "KK"}, {"family": "Delaney", "given": "Shani", "initials": "S"}, {"family": "Delgado", "given": "Carlos", "initials": "C"}, {"family": "Schippers", "given": "Adrienne", "initials": "A"}, {"family": "Munson", "given": "Jeff", "initials": "J"}, {"family": "Pottinger", "given": "Paul S", "initials": "PS"}, {"family": "Cohen", "given": "Seth", "initials": "S"}, {"family": "Neme", "given": "Santiago", "initials": "S"}, {"family": "Bourassa", "given": "Lori", "initials": "L"}, {"family": "Bryan", "given": "Andrew", "initials": "A"}, {"family": "Greninger", "given": "Alex", "initials": "A"}, {"family": "Jerome", "given": "Keith R", "initials": "KR"}, {"family": "Roxby", "given": "Alison C", "initials": "AC"}, {"family": "Lokken", "given": "Erica", "initials": "E"}, {"family": "Cheng", "given": "Edith", "initials": "E"}, {"family": "Adams Waldorf", "given": "Kristina M", "initials": "KM"}, {"family": "Hitti", "given": "Jane", "initials": "J"}], "type": "journal article", "published": "2020-05-30", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "volume": null, "issue": null, "issn-l": "1058-4838"}, "abstract": "We found a low prevalence of SARS-CoV-2 (2.7% [5/188]) among pregnant and postpartum patients after initiating universal testing. Prevalence among symptomatic patients (22.2% [4/18]) was similar to initial targeted screening approaches (19.1% [8/42]). Among 170 asymptomatic patients, two were positive or inconclusive, respectively; repeat testing at 24 hours was negative.", "doi": "10.1093/cid/ciaa675", "pmid": "32472688", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "5848913"}, {"db": "pmc", "key": "PMC7314151"}], "notes": [], "created": "2020-12-09T11:02:45.999Z", "modified": "2021-02-26T08:45:48.879Z"}, {"entity": "publication", "iuid": "619f0e5a1caf46a19db29becd97df2c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/619f0e5a1caf46a19db29becd97df2c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/619f0e5a1caf46a19db29becd97df2c9"}}, "title": "Effect of COVID-19 response in Uganda on street children", "authors": [{"family": "Kawala", "given": "Brenda Allen", "initials": "BA"}, {"family": "Kirui", "given": "Brian Kibiwott", "initials": "BK"}, {"family": "Cumber", "given": "Samuel Nambile", "initials": "SN"}], "type": "journal-article", "published": "2020-05-29", "journal": {"title": "Pan Afr Med J", "issn": "1937-8688", "volume": "35", "issue": "Supp 2", "pages": "56", "issn-l": null}, "abstract": null, "doi": "10.11604/pamj.supp.2020.35.2.23545", "pmid": "33623581", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-25T10:10:48.886Z", "modified": "2021-02-25T10:11:23.119Z"}, {"entity": "publication", "iuid": "71cc0f9b690a4930a5aa7d9d71e51587", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/71cc0f9b690a4930a5aa7d9d71e51587.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/71cc0f9b690a4930a5aa7d9d71e51587"}}, "title": "Assessing Psychological Response to the COVID-19: The Fear of COVID-19 Scale and the COVID Stress Scales.", "authors": [{"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}], "type": "journal article", "published": "2020-05-29", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "volume": null, "issue": null, "pages": "1-4", "issn-l": null}, "abstract": null, "doi": "10.1007/s11469-020-00334-9", "pmid": "32837424", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "334"}, {"db": "pmc", "key": "PMC7259433"}], "notes": [], "created": "2020-12-07T10:36:43.662Z", "modified": "2020-12-07T10:36:43.672Z"}, {"entity": "publication", "iuid": "0920ab25f86e4d27a1b9f3378fa735b8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0920ab25f86e4d27a1b9f3378fa735b8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0920ab25f86e4d27a1b9f3378fa735b8"}}, "title": "Serological tests should be related to the aim of the testing, as well as the population.", "authors": [{"family": "Modig", "given": "Karin", "initials": "K"}, {"family": "Gem\u00e9s", "given": "Katalin", "initials": "K"}, {"family": "Feychting", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2020-05-27", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": "Expectations are high on serological tests for SARS-CoV-2. Further knowledge of the immunity is needed, but also evaluation of the reliability of the tests. Important for the latter is for which purpose the test is conducted and how common the outcome to be identified is (antibodies). For the determination of immunity at the individual level, the specificity of the test must be very high, preferably 100%. Even tests where the specificity is perceived as high, e.g. 95% or 99%, can lead to a large proportion of false positives, if the proportion of the population actually infected is small.", "doi": null, "pmid": "32463477", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "20081"}], "notes": [], "created": "2020-11-25T08:22:02.643Z", "modified": "2023-06-19T14:48:59.968Z"}, {"entity": "publication", "iuid": "a9b5a357258d4cec9ee60f09d0a2dc3b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a9b5a357258d4cec9ee60f09d0a2dc3b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a9b5a357258d4cec9ee60f09d0a2dc3b"}}, "title": "Rapid point-of-care serology testing for sars-cov-2", "authors": [{"family": "Stackelberg", "given": "Otto", "initials": "O"}, {"family": "Esmaeilzadeh", "given": "Mouna", "initials": "M"}, {"family": "Olsen", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "journal article", "published": "2020-05-27", "journal": {"title": "L\u00e4kartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": "Increasing evidence indicates immunity against severe acute respiratory syndrome coronavirus 2 (sars-cov-2) after covid-19, but it remains unclear for how long the protection remains. Serology testing seems to have a higher sensitivity than molecular diagnostics from 8 days after onset of symtoms, and should be part of risk assessment and epidemiological studies of COVID-19. The performance of commercial serological point-of-care (POC) lateral flow tests are highly manufacturer-dependant. Low sensitivity increases the risk of false negative results and could result in unnecessary quarantine of test persons with developed antibodies. Low specificity increases the risk of false positive results and could lead to false assumptions of immunity. Carefully selected serological POC tests for sars-cov-2 can be used in large scale testing but should only be used by licensed medical staff able to understand their limitations and interpret the results.", "doi": null, "pmid": "32463475", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "20078"}], "notes": [], "created": "2020-11-11T07:18:07.394Z", "modified": "2021-01-17T08:19:34.625Z"}, {"entity": "publication", "iuid": "69a038d2c6724972a73cb9af9a52933a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69a038d2c6724972a73cb9af9a52933a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69a038d2c6724972a73cb9af9a52933a"}}, "title": "Could SARS-CoV-2-Induced Hyperinflammation Magnify the Severity of Coronavirus Disease (CoViD-19) Leading to Acute Respiratory Distress Syndrome?", "authors": [{"family": "Girija", "given": "A S Smiline", "initials": "ASS"}, {"family": "Shankar", "given": "Esaki M", "initials": "EM"}, {"family": "Larsson", "given": "Marie", "initials": "M"}], "type": "journal-article", "published": "2020-05-27", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "11", "issue": null, "pages": "1206", "issn-l": "1664-3224"}, "abstract": null, "doi": "10.3389/fimmu.2020.01206", "pmid": "32574269", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7267050"}], "notes": [], "created": "2020-12-08T16:20:21.680Z", "modified": "2021-12-06T13:19:34.348Z"}, {"entity": "publication", "iuid": "c1f61053726a446fa7eafc9b35b98a00", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1f61053726a446fa7eafc9b35b98a00.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1f61053726a446fa7eafc9b35b98a00"}}, "title": "Early Phylogenetic Diversification of SARS-CoV-2: Determination of Variants and the Effect on Epidemiology, Immunology, and Diagnostics", "authors": [{"family": "Kaden", "given": "Rene", "initials": "R", "orcid": "0000-0002-2111-9751", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2be6374ef0bf4ba39e5f5dbbb059747f.json"}}], "type": "journal-article", "published": "2020-05-26", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "9", "issue": "6", "pages": "1615", "issn-l": "2077-0383"}, "abstract": "The phylogenetic clustering of 95 SARS-CoV-2 sequences from the first 3 months of the pandemic reveals insights into the early evolution of the virus and gives first indications of how the variants are globally distributed. Variants might become a challenge in terms of diagnostics, immunology, and effectiveness of drugs. All available whole genome sequence data from the NCBI database (March 16, 2020) were phylogenetically analyzed, and gene prediction as well as analysis of selected variants were performed. Antigenic regions and the secondary protein structure were predicted for selected variants. While some clusters are presenting the same variant with 100% identical bases, other SARS-CoV-2 lineages show a beginning diversification and phylogenetic clustering due to base substitutions and deletions in the genomes. First molecular epidemiological investigations are possible with the results by adding metadata as travelling history to the presented data. The advantage of variants in source tracing can be a challenge in terms of virulence, immune response, and immunological memory. Variants of viruses often show differences in virulence or antigenicity. This must also be considered in decisions like herd immunity. Diagnostic methods might not work if the variations or deletions are in target regions for the detection of the pathogen. One base substitution was detected in a primer binding site.", "doi": "10.3390/jcm9061615", "pmid": "32466577", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "jcm9061615"}, {"db": "pmc", "key": "PMC7356205"}], "notes": [], "created": "2020-11-19T14:22:24.295Z", "modified": "2021-12-06T13:19:14.235Z"}, {"entity": "publication", "iuid": "135a6c58b8464dc2a03b65a276926648", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/135a6c58b8464dc2a03b65a276926648.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/135a6c58b8464dc2a03b65a276926648"}}, "title": "Environmental impact of the COVID-19 pandemic - a lesson for the future.", "authors": [{"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME", "orcid": "0000-0002-1056-4761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58d2f06f64154a2f9b5b22ffbb7518a3.json"}}, {"family": "Young", "given": "Sean G", "initials": "SG", "orcid": "0000-0002-0054-0627", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47701de524284532ba5e23aac25c1c6e.json"}}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD", "orcid": "0000-0002-7075-1059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4c50079915c44d39c996741c6156bfa.json"}}], "type": "editorial", "published": "2020-05-25", "journal": {"title": "Infect Ecol Epidemiol", "issn": "2000-8686", "issn-l": "2000-8686", "volume": "10", "issue": "1", "pages": "1768023"}, "abstract": "The environment is an integral component of human and animal health. COVID-19 is a global health challenge in the twenty-first century. The emergence of SARS-CoV-2 in Wuhan, China in December 2019, and its spread to regional countries and nowadays affecting more than 210 countries worldwide represents the first pandemic in history to be caused by a coronavirus. The COVID-19 pandemic has huge impacts on most aspects of human activities, as well as on the economy and health care systems. Lock-downs, quarantines and border closures in the wake of the pandemic have led to reductions in air pollution through decreased travel and production. These positive environmental effects are likely mostly temporary, but may serve as an example that changes in our way of life can have prompt positive effects for the environment and demonstrate the usefulness of travel-reducing measures such as teleconferencing. Thus, acknowledging that COVID-19 is first and foremost a global disaster, the pandemic may inspire to future behavioral changes with positive environmental effects.", "doi": "10.1080/20008686.2020.1768023", "pmid": "32922688", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "1768023"}, {"db": "pmc", "key": "PMC7448928"}], "notes": [], "created": "2020-11-22T09:32:53.923Z", "modified": "2021-12-06T13:18:56.009Z"}, {"entity": "publication", "iuid": "085268aa10e74516b1448ef2d74d1975", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/085268aa10e74516b1448ef2d74d1975.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/085268aa10e74516b1448ef2d74d1975"}}, "title": "Clinical and daily respiratory care and clinical trials within the COVID-19 era.", "authors": [{"family": "Diamant", "given": "Zuzana", "initials": "Z", "orcid": "0000-0003-0133-0100", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09c10bc9b15d4e8e80bfd0b11766bb58.json"}}, {"family": "Backer", "given": "Vibeke", "initials": "V", "orcid": "0000-0002-7806-7219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/559002d5b8384167b98a692e0a26a30f.json"}}, {"family": "Bjermer", "given": "Leif", "initials": "L", "orcid": "0000-0002-3441-8099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00285adfb31749e9a0c62eaa99b0b373.json"}}], "type": "editorial", "published": "2020-05-25", "journal": {"title": "Eur Clin Respir J", "issn": "2001-8525", "issn-l": null, "volume": "7", "issue": "1", "pages": "1766817"}, "abstract": "Editorial", "doi": "10.1080/20018525.2020.1766817", "pmid": "32922694", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "1766817"}, {"db": "pmc", "key": "PMC7448908"}], "notes": [], "created": "2020-12-03T15:48:16.477Z", "modified": "2021-12-06T13:18:38.752Z"}, {"entity": "publication", "iuid": "3f3785befa6c48f79fd5365680857182", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f3785befa6c48f79fd5365680857182.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f3785befa6c48f79fd5365680857182"}}, "title": "Gambling During the COVID-19 Crisis - A Cause for Concern.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "Fern\u00e1ndez-Aranda", "given": "Fernando", "initials": "F"}, {"family": "Mench\u00f3n", "given": "Jose M", "initials": "JM"}, {"family": "Potenza", "given": "Marc N", "initials": "MN"}, {"family": "Jim\u00e9nez-Murcia", "given": "Susana", "initials": "S"}], "type": "journal article", "published": "2020-05-21", "journal": {"title": "J Addict Med", "issn": "1935-3227", "volume": "14", "issue": "4", "pages": "e10-e12", "issn-l": null}, "abstract": ": The COVID-19 pandemic has the potential to worsen mental health problems in the general population, including increasing engagement in addictive behaviors. Here, we describe observations suggesting that the current crisis and its sequelae may worsen problem gambling. The current pandemic may impact financial and psychological well-being due to social isolation during spatial distancing, and these stressors in conjunction with substantial changes in gambling markets (land-based, online) during the pandemic may significantly influence gambling behaviors. This situation calls for rapid research initiatives in this area and preventive and regulatory measures by multiple stakeholders.", "doi": "10.1097/ADM.0000000000000690", "pmid": "32433365", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7273946"}], "notes": [], "created": "2020-12-09T11:37:03.546Z", "modified": "2021-12-06T13:17:38.631Z"}, {"entity": "publication", "iuid": "9c189a14da4c4d81a9fdfe210ce73acc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9c189a14da4c4d81a9fdfe210ce73acc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9c189a14da4c4d81a9fdfe210ce73acc"}}, "title": "Chemical Functionalization of 2D Materials", "authors": [{"family": "Mart\u00edn", "given": "Nazario", "initials": "N"}, {"family": "Tagmatarchis", "given": "Nikos", "initials": "N", "orcid": "0000-0001-7590-4635", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68a0b82ac2764eb1951d727f8ec53c51.json"}}, {"family": "Wang", "given": "Qing Hua", "initials": "QH", "orcid": "0000-0002-7982-7275", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8777f9f0f45646309baebeddf649856c.json"}}, {"family": "Zhang", "given": "Xiaoyan", "initials": "X", "orcid": "0000-0002-5469-8630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09b21da8cac141c29584498d44511889.json"}}], "type": "journal-article", "published": "2020-05-20", "journal": {"title": "Chem. Eur. J.", "issn": "0947-6539", "volume": "26", "issue": "29", "pages": "6292-6295", "issn-l": null}, "abstract": "This Special Issue of Chemistry-A European Journal is dedicated to the Chemical Functionalization of 2D Materials, and features some great contributions from experts in the field of 2D materials. This issue was originally assembled to support the Symposium G \"Chemical Functionalization of 2D Materials\" at the European Materials Research Society (E-MRS) 2020 Spring Meeting, which was originally scheduled to be held in Strasbourg, France, from May 25th to 29th, 2020. Although the E-MRS 2020 Spring Meeting has been cancelled due to the COVID-19 outbreak, the publication of this Special Issue has proceeded and has become even more important as the contributors discuss diverse and timely research themes related to 2D materials. In this Editorial, a brief overview of the different types of 2D materials is given, together with the chemical functionalization schemes that can be applied to them to achieve new properties as well as enable improved performance in applications. Some of the articles featured in this Special Issue are also highlighted, with the hope that they will inspire readers and further advance the field.", "doi": "10.1002/chem.202001304", "pmid": "32432399", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-09T11:38:10.781Z", "modified": "2021-12-06T13:16:27.356Z"}, {"entity": "publication", "iuid": "0a042c1b6ea14982811ebbf1d8386f35", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a042c1b6ea14982811ebbf1d8386f35.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a042c1b6ea14982811ebbf1d8386f35"}}, "title": "The pandemic of social media panic travels faster than the COVID-19 outbreak", "authors": [{"family": "Depoux", "given": "Anneliese", "initials": "A"}, {"family": "Martin", "given": "Sam", "initials": "S"}, {"family": "Karafillakis", "given": "Emilie", "initials": "E"}, {"family": "Preet", "given": "Raman", "initials": "R"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Larson", "given": "Heidi", "initials": "H"}], "type": "journal-article", "published": "2020-05-18", "journal": {"title": "J Travel Med", "issn": "1708-8305", "volume": "27", "issue": "3", "issn-l": null}, "abstract": null, "doi": "10.1093/jtm/taaa031", "pmid": "32125413", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5775501"}, {"db": "pmc", "key": "PMC7107516"}], "notes": [], "created": "2020-12-08T06:51:36.786Z", "modified": "2021-12-06T13:15:04.146Z"}, {"entity": "publication", "iuid": "6b6f0a046e184dc19d670a98b5567b07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b6f0a046e184dc19d670a98b5567b07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b6f0a046e184dc19d670a98b5567b07"}}, "title": "High population densities catalyse the spread of COVID-19", "authors": [{"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}, {"family": "Sj\u00f6din", "given": "Henrik", "initials": "H"}], "type": "journal-article", "published": "2020-05-18", "journal": {"title": "J Travel Med", "issn": "1708-8305", "volume": "27", "issue": "3", "issn-l": null}, "abstract": null, "doi": "10.1093/jtm/taaa038", "pmid": "32227186", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5807719"}, {"db": "pmc", "key": "PMC7184409"}], "notes": [], "created": "2020-12-09T11:47:10.998Z", "modified": "2021-12-06T13:14:39.528Z"}, {"entity": "publication", "iuid": "3a86650407624b3db05844404767e6c6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a86650407624b3db05844404767e6c6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a86650407624b3db05844404767e6c6"}}, "title": "COVID-19 outbreak on the Diamond Princess cruise ship: estimating the epidemic potential and effectiveness of public health countermeasures", "authors": [{"family": "Rockl\u00f6v", "given": "J", "initials": "J"}, {"family": "Sj\u00f6din", "given": "H", "initials": "H"}, {"family": "Wilder-Smith", "given": "A", "initials": "A"}], "type": "journal-article", "published": "2020-05-18", "journal": {"title": "J Travel Med", "issn": "1708-8305", "issn-l": null, "volume": "27", "issue": "3", "pages": null}, "abstract": "Cruise ships carry a large number of people in confined spaces with relative homogeneous mixing. On 3 February, 2020, an outbreak of COVID-19 on cruise ship Diamond Princess was reported with 10 initial cases, following an index case on board around 21-25th January. By 4th February, public health measures such as removal and isolation of ill passengers and quarantine of non-ill passengers were implemented. By 20th February, 619 of 3700 passengers and crew (17%) were tested positive.\n\nWe estimated the basic reproduction number from the initial period of the outbreak using SEIR models. We calibrated the models with transient functions of countermeasures to incidence data. We additionally estimated a counterfactual scenario in absence of countermeasures, and established a model stratified by crew and guests to study the impact of differential contact rates among the groups. We also compared scenarios of an earlier versus later evacuation of the ship.\n\nThe basic reproduction rate was initially 4 times higher on-board compared to the ${R}_0$ in the epicentre in Wuhan, but the countermeasures lowered it substantially. Based on the modeled initial ${R}_0$ of 14.8, we estimated that without any interventions within the time period of 21 January to 19 February, 2920 out of the 3700 (79%) would have been infected. Isolation and quarantine therefore prevented 2307 cases, and lowered the ${R}_0$ to 1.78. We showed that an early evacuation of all passengers on 3 February would have been associated with 76 infected persons in their incubation time.\n\nThe cruise ship conditions clearly amplified an already highly transmissible disease. The public health measures prevented more than 2000 additional cases compared to no interventions. However, evacuating all passengers and crew early on in the outbreak would have prevented many more passengers and crew from infection.", "doi": "10.1093/jtm/taaa030", "pmid": "32109273", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "5766334"}, {"db": "pmc", "key": "PMC7107563"}], "notes": [], "created": "2020-12-08T06:57:54.802Z", "modified": "2021-12-06T13:14:19.397Z"}, {"entity": "publication", "iuid": "9fc6eb922a5a4c6db0605957f1abc618", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9fc6eb922a5a4c6db0605957f1abc618.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9fc6eb922a5a4c6db0605957f1abc618"}}, "title": "Esophageal oncologic surgery in SARS-CoV-2 (COVID-19) emergency", "authors": [{"family": "Barbieri", "given": "Lavinia", "initials": "L"}, {"family": "Talavera Urquijo", "given": "Eider", "initials": "E", "orcid": "0000-0002-4793-5378", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db65329d4f1f487fa3afd522549e7430.json"}}, {"family": "Parise", "given": "Paolo", "initials": "P"}, {"family": "Nilsson", "given": "Magnus", "initials": "M"}, {"family": "Reynolds", "given": "John V", "initials": "JV"}, {"family": "Rosati", "given": "Riccardo", "initials": "R"}], "type": "journal-article", "published": "2020-05-15", "journal": {"title": "Dis Esophagus", "issn": "1442-2050", "volume": "33", "issue": "5", "pages": null, "issn-l": "1120-8694"}, "abstract": "Guidelines", "doi": "10.1093/dote/doaa028", "pmid": "32322892", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5823899"}, {"db": "pmc", "key": "PMC7188144"}], "notes": [], "created": "2020-11-23T11:45:36.075Z", "modified": "2021-12-06T13:13:34.720Z"}, {"entity": "publication", "iuid": "c9ed13bb0adf4357acdc4ce11d04ed45", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9ed13bb0adf4357acdc4ce11d04ed45.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9ed13bb0adf4357acdc4ce11d04ed45"}}, "title": "Deubiquitinating Enzymes in Coronaviruses and Possible Therapeutic Opportunities for COVID-19", "authors": [{"family": "Clemente", "given": "Valentino", "initials": "V"}, {"family": "D\u2019Arcy", "given": "Padraig", "initials": "P"}, {"family": "Bazzaro", "given": "Martina", "initials": "M"}], "type": "journal-article", "published": "2020-05-15", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "21", "issue": "10", "pages": "3492", "issn-l": null}, "abstract": "Following the outbreak of novel severe acute respiratory syndrome (SARS)-coronavirus (CoV)2, the majority of nations are struggling with countermeasures to fight infection, prevent spread and improve patient survival. Considering that the pandemic is a recent event, no large clinical trials have been possible and since coronavirus specific drug are not yet available, there is no strong consensus on how to treat the coronavirus disease 2019 (COVID-19) associated viral pneumonia. Coronaviruses code for an important multifunctional enzyme named papain-like protease (PLP), that has many roles in pathogenesis. First, PLP is one of the two viral cysteine proteases, along with 3-chymotripsin-like protease, that is responsible for the production of the replicase proteins required for viral replication. Second, its intrinsic deubiquitinating and deISGylating activities serve to antagonize the host's immune response that would otherwise hinder infection. Both deubiquitinating and deISGylating functions involve the removal of the small regulatory polypeptides, ubiquitin and ISG15, respectively, from target proteins. Ubiquitin modifications can regulate the innate immune response by affecting regulatory proteins, either by altering their stability via the ubiquitin proteasome pathway or by directly regulating their activity. ISG15 is a ubiquitin-like modifier with pleiotropic effects, typically expressed during the host cell immune response. PLP inhibitors have been evaluated during past coronavirus epidemics, and have showed promising results as an antiviral therapy in vitro. In this review, we recapitulate the roles of PLPs in coronavirus infections, report a list of PLP inhibitors and suggest possible therapeutic strategies for COVID-19 treatment, using both clinical and preclinical drugs.", "doi": "10.3390/ijms21103492", "pmid": "32429099", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijms21103492"}, {"db": "pmc", "key": "PMC7278987"}], "notes": [], "created": "2020-11-30T09:04:50.366Z", "modified": "2021-12-06T13:13:11.678Z"}, {"entity": "publication", "iuid": "13a9b64f789f4868a0c2bbb0b75fe84c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13a9b64f789f4868a0c2bbb0b75fe84c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13a9b64f789f4868a0c2bbb0b75fe84c"}}, "title": "COVID-19-Related Suicides in Bangladesh Due to Lockdown and Economic Factors: Case Study Evidence from Media Reports.", "authors": [{"family": "Bhuiyan", "given": "A K M Israfil", "initials": "AKMI"}, {"family": "Sakib", "given": "Najmuj", "initials": "N"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA"}], "type": "journal article", "published": "2020-05-15", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "volume": null, "issue": null, "pages": "1-6", "issn-l": null}, "abstract": null, "doi": "10.1007/s11469-020-00307-y", "pmid": "32427168", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "307"}, {"db": "pmc", "key": "PMC7228428"}], "notes": [], "created": "2020-12-09T11:40:51.584Z", "modified": "2021-12-06T13:12:52.761Z"}, {"entity": "publication", "iuid": "5669972f04844d0c8d2663e7733278b7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5669972f04844d0c8d2663e7733278b7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5669972f04844d0c8d2663e7733278b7"}}, "title": "Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2.", "authors": [{"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Kwon", "given": "Hyesoo", "initials": "H"}, {"family": "Prado", "given": "Patricia", "initials": "P"}, {"family": "Hagelkr\u00fcys", "given": "Astrid", "initials": "A"}, {"family": "Wimmer", "given": "Reiner A", "initials": "RA"}, {"family": "Stahl", "given": "Martin", "initials": "M"}, {"family": "Leopoldi", "given": "Alexandra", "initials": "A"}, {"family": "Garreta", "given": "Elena", "initials": "E"}, {"family": "Hurtado Del Pozo", "given": "Carmen", "initials": "C"}, {"family": "Prosper", "given": "Felipe", "initials": "F"}, {"family": "Romero", "given": "Juan Pablo", "initials": "JP"}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G"}, {"family": "Zhang", "given": "Haibo", "initials": "H"}, {"family": "Slutsky", "given": "Arthur S", "initials": "AS"}, {"family": "Conder", "given": "Ryan", "initials": "R"}, {"family": "Montserrat", "given": "Nuria", "initials": "N"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}], "type": "journal article", "published": "2020-05-14", "journal": {"title": "Cell", "issn": "1097-4172", "issn-l": "0092-8674", "volume": "181", "issue": "4", "pages": "905-913.e7"}, "abstract": "We have previously provided the first genetic evidence that angiotensin converting enzyme 2 (ACE2) is the critical receptor for severe acute respiratory syndrome coronavirus (SARS-CoV), and ACE2 protects the lung from injury, providing a molecular explanation for the severe lung failure and death due to SARS-CoV infections. ACE2 has now also been identified as a key receptor for SARS-CoV-2 infections, and it has been proposed that inhibiting this interaction might be used in treating patients with COVID-19. However, it is not known whether human recombinant soluble ACE2 (hrsACE2) blocks growth of SARS-CoV-2. Here, we show that clinical grade hrsACE2 reduced SARS-CoV-2 recovery from Vero cells by a factor of 1,000-5,000. An equivalent mouse rsACE2 had no effect. We also show that SARS-CoV-2 can directly infect engineered human blood vessel organoids and human kidney organoids, which can be inhibited by hrsACE2. These data demonstrate that hrsACE2 can significantly block early stages of SARS-CoV-2 infections.", "doi": "10.1016/j.cell.2020.04.004", "pmid": "32333836", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: H2020": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0092-8674(20)30399-8"}, {"db": "pmc", "key": "PMC7181998"}], "notes": [], "created": "2020-12-09T14:57:55.780Z", "modified": "2021-12-06T13:12:24.868Z"}, {"entity": "publication", "iuid": "2ce4cebb6df144ffae6ee014ab7b79a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ce4cebb6df144ffae6ee014ab7b79a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ce4cebb6df144ffae6ee014ab7b79a6"}}, "title": "EAPCI Position Statement on Invasive Management of Acute Coronary Syndromes during the COVID-19 pandemic.", "authors": [{"family": "Chieffo", "given": "Alaide", "initials": "A"}, {"family": "Stefanini", "given": "Giulio G", "initials": "GG"}, {"family": "Price", "given": "Susanna", "initials": "S"}, {"family": "Barbato", "given": "Emanuele", "initials": "E"}, {"family": "Tarantini", "given": "Giuseppe", "initials": "G"}, {"family": "Karam", "given": "Nicole", "initials": "N"}, {"family": "Moreno", "given": "Raul", "initials": "R"}, {"family": "Buchanan", "given": "Gill Louise", "initials": "GL"}, {"family": "Gilard", "given": "Martine", "initials": "M"}, {"family": "Halvorsen", "given": "Sigrun", "initials": "S"}, {"family": "Huber", "given": "Kurt", "initials": "K"}, {"family": "James", "given": "Stefan", "initials": "S"}, {"family": "Neumann", "given": "Franz-Josef", "initials": "FJ"}, {"family": "M\u00f6llmann", "given": "Helge", "initials": "H"}, {"family": "Roffi", "given": "Marco", "initials": "M"}, {"family": "Tavazzi", "given": "Guido", "initials": "G"}, {"family": "Mauri Ferr\u00e9", "given": "Josepa", "initials": "J"}, {"family": "Windecker", "given": "Stephan", "initials": "S"}, {"family": "Dudek", "given": "Dariusz", "initials": "D"}, {"family": "Baumbach", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2020-05-14", "journal": {"title": "Eur Heart J", "issn": "1522-9645", "volume": "41", "issue": "19", "pages": "1839-1851", "issn-l": "0195-668X"}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic poses an unprecedented challenge to healthcare worldwide. The infection can be life threatening and require intensive care treatment. The transmission of the disease poses a risk to both patients and healthcare workers. The number of patients requiring hospital admission and intensive care may overwhelm health systems and negatively affect standard care for patients presenting with conditions needing emergency interventions. This position statements aims to assist cardiologists in the invasive management of acute coronary syndrome (ACS) patients in the context of the COVID-19 pandemic. To that end, we assembled a panel of interventional cardiologists and acute cardiac care specialists appointed by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) and from the Acute Cardiovascular Care Association (ACVC) and included the experience from the first and worst affected areas in Europe. Modified diagnostic and treatment algorithms are proposed to adapt evidence-based protocols for this unprecedented challenge. Various clinical scenarios, as well as management algorithms for patients with a diagnosed or suspected COVID-19 infection, presenting with ST- and non-ST-segment elevation ACS are described. In addition, we address the need for re-organization of ACS networks, with redistribution of hub and spoke hospitals, as well as for in-hospital reorganization of emergency rooms and cardiac units, with examples coming from multiple European countries. Furthermore, we provide a guidance to reorganization of catheterization laboratories and, importantly, measures for protection of healthcare providers involved with invasive procedures.", "doi": "10.1093/eurheartj/ehaa381", "pmid": "32405641", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5836093"}, {"db": "pmc", "key": "PMC7239193"}], "notes": [], "created": "2020-12-10T08:49:39.425Z", "modified": "2021-12-06T13:12:03.006Z"}, {"entity": "publication", "iuid": "bad2b8ef26c14d8ea4275d7fdce85d0b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bad2b8ef26c14d8ea4275d7fdce85d0b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bad2b8ef26c14d8ea4275d7fdce85d0b"}}, "title": "Recommendations for Physical Inactivity and Sedentary Behavior During the Coronavirus Disease (COVID-19) Pandemic.", "authors": [{"family": "Ricci", "given": "Fabrizio", "initials": "F"}, {"family": "Izzicupo", "given": "Pascal", "initials": "P"}, {"family": "Moscucci", "given": "Federica", "initials": "F"}, {"family": "Sciomer", "given": "Susanna", "initials": "S"}, {"family": "Maffei", "given": "Silvia", "initials": "S"}, {"family": "Di Baldassarre", "given": "Angela", "initials": "A"}, {"family": "Mattioli", "given": "Anna Vittoria", "initials": "AV"}, {"family": "Gallina", "given": "Sabina", "initials": "S"}], "type": "journal article", "published": "2020-05-12", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "199", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2020.00199", "pmid": "32574294", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7235318"}], "notes": [], "created": "2020-12-08T16:18:42.625Z", "modified": "2021-12-06T13:11:44.902Z"}, {"entity": "publication", "iuid": "42a9ec324c29452b9841ab1130a695bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/42a9ec324c29452b9841ab1130a695bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/42a9ec324c29452b9841ab1130a695bd"}}, "title": "Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 \u2013 implications for microvascular inflammation and hypercoagulopathy in COVID-19", "authors": [{"family": "He", "given": "Liqun", "initials": "L"}, {"family": "M\u00e4e", "given": "Maarja Andaloussi", "initials": "MA"}, {"family": "Muhl", "given": "Lars", "initials": "L"}, {"family": "Sun", "given": "Ying", "initials": "Y"}, {"family": "Pietil\u00e4", "given": "Riikka", "initials": "R"}, {"family": "Nahar", "given": "Khayrun", "initials": "K"}, {"family": "Li\u00e9banas", "given": "Elisa V\u00e1zquez", "initials": "EV"}, {"family": "Fagerlund", "given": "Malin Jonsson", "initials": "MJ"}, {"family": "Oldner", "given": "Anders", "initials": "A"}, {"family": "Liu", "given": "Jianping", "initials": "J"}, {"family": "Genov\u00e9", "given": "Guillem", "initials": "G"}, {"family": "Zhang", "given": "Lei", "initials": "L"}, {"family": "Xie", "given": "Yuan", "initials": "Y"}, {"family": "Leptidis", "given": "Stefanos", "initials": "S"}, {"family": "Mocci", "given": "Giuseppe", "initials": "G"}, {"family": "Stritt", "given": "Simon", "initials": "S"}, {"family": "Osman", "given": "Ahmed", "initials": "A"}, {"family": "Anisimov", "given": "Andrey", "initials": "A"}, {"family": "Hemanthakumar", "given": "Karthik Amudhala", "initials": "KA"}, {"family": "R\u00e4s\u00e4nen", "given": "Markus", "initials": "M"}, {"family": "Mirabeau", "given": "Olivier", "initials": "O"}, {"family": "Hansson", "given": "Emil", "initials": "E"}, {"family": "Bj\u00f6rkegren", "given": "Johan", "initials": "J"}, {"family": "Vanlandewijck", "given": "Michael", "initials": "M"}, {"family": "Blomgren", "given": "Klas", "initials": "K"}, {"family": "M\u00e4kinen", "given": "Taija", "initials": "T"}, {"family": "Peng", "given": "Xiao Rong", "initials": "XR"}, {"family": "Arnold", "given": "Thomas D", "initials": "TD"}, {"family": "Alitalo", "given": "Kari", "initials": "K"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Lendahl", "given": "Urban", "initials": "U"}, {"family": "Betsholtz", "given": "Christer", "initials": "C"}], "type": "posted-content", "published": "2020-05-12", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.05.11.088500", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-20T06:40:52.233Z", "modified": "2021-12-06T13:11:25.970Z"}, {"entity": "publication", "iuid": "614cd9f9b80d48699960dc262af705ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/614cd9f9b80d48699960dc262af705ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/614cd9f9b80d48699960dc262af705ff"}}, "title": "Coronavirus Disease 2019 Return to Work Guidance and Recommendations for Vestibular Clinicians", "authors": [{"family": "Rizk", "given": "Habib G", "initials": "HG"}, {"family": "Strange", "given": "Christine", "initials": "C"}, {"family": "Atallah", "given": "Stephanie", "initials": "S"}, {"family": "Massingale", "given": "Shelly", "initials": "S"}, {"family": "Clendaniel", "given": "Richard", "initials": "R"}], "type": "journal-article", "published": "2020-05-12", "journal": {"title": "Ear Hear", "issn": "1538-4667", "volume": "41", "issue": "4", "pages": "693-696", "issn-l": null}, "abstract": "As states begin issuing progressive deconfinement guidelines, hospitals and institutions are starting to reopen for elective procedures and consultations. Vestibular clinicians are opening their practices to evaluate, test, or treat patients with dizziness and balance problems. The following document, requested by the American Balance Society, collates the current information about the virus, including transmission from asymptomatic carriers, decontamination, and other safety protocols, and provides a return to work guidance for clinicians caring for this population of patients, promoting provider, patient, and staff safety.", "doi": "10.1097/aud.0000000000000903", "pmid": "32427744", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-09T11:39:58.568Z", "modified": "2021-12-06T13:16:51.259Z"}, {"entity": "publication", "iuid": "626155cf829443a982103aceb07bea87", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/626155cf829443a982103aceb07bea87.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/626155cf829443a982103aceb07bea87"}}, "title": "Psychometric Validation of the Bangla Fear of COVID-19 Scale: Confirmatory Factor Analysis and Rasch Analysis", "authors": [{"family": "Sakib", "given": "Najmuj", "initials": "N"}, {"family": "Bhuiyan", "given": "A K M Israfil", "initials": "AKMI"}, {"family": "Hossain", "given": "Sahadat", "initials": "S"}, {"family": "Al Mamun", "given": "Firoj", "initials": "F"}, {"family": "Hosen", "given": "Ismail", "initials": "I"}, {"family": "Abdullah", "given": "Abu Hasnat", "initials": "AH"}, {"family": "Sarker", "given": "Md Abedin", "initials": "MA"}, {"family": "Mohiuddin", "given": "Mohammad Sarif", "initials": "MS"}, {"family": "Rayhan", "given": "Istihak", "initials": "I"}, {"family": "Hossain", "given": "Moazzem", "initials": "M"}, {"family": "Sikder", "given": "Md Tajuddin", "initials": "MT"}, {"family": "Gozal", "given": "David", "initials": "D"}, {"family": "Muhit", "given": "Mohammad", "initials": "M"}, {"family": "Islam", "given": "S M Shariful", "initials": "SMS"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA", "orcid": "0000-0002-1728-8966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6e65a5a97154d159a63cc2ce3f1b7a8.json"}}], "type": "journal-article", "published": "2020-05-11", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "issn-l": null, "volume": null, "issue": null, "pages": "1-12"}, "abstract": "The recently developed Fear of COVID-19 Scale (FCV-19S) is a seven-item uni-dimensional scale that assesses the severity of fears of COVID-19. Given the rapid increase of COVID-19 cases in Bangladesh, we aimed to translate and validate the FCV-19S in Bangla. The forward-backward translation method was used to translate the English version of the questionnaire into Bangla. The reliability and validity properties of the Bangla FCV-19S were rigorously psychometrically evaluated (utilizing both confirmatory factor analysis and Rasch analysis) in relation to socio-demographic variables, national lockdown variables, and response to the Bangla Health Patient Questionnaire. The sample comprised 8550 Bangladeshi participants. The Cronbach \u03b1 value for the Bangla FCV-19S was 0.871 indicating very good internal reliability. The results of the confirmatory factor analysis showed that the uni-dimensional factor structure of the FCV-19S fitted well with the data. The FCV-19S was significantly correlated with the nine-item Bangla Patient Health Questionnaire (PHQ-90) (r = 0.406, p < 0.001). FCV-19S scores were significantly associated with higher worries concerning lockdown. Measurement invariance of the FCV-19S showed no differences with respect to age or gender. The Bangla version of FCV-19S is a valid and reliable tool with robust psychometric properties which will be useful for researchers carrying out studies among the Bangla speaking population in assessing the psychological impact of fear from COVID-19 infection during this pandemic.", "doi": "10.1007/s11469-020-00289-x", "pmid": "32395096", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "289"}, {"db": "pmc", "key": "PMC7213549"}], "notes": [], "created": "2020-12-10T08:40:21.782Z", "modified": "2021-12-06T13:11:04.811Z"}, {"entity": "publication", "iuid": "884f876e112344c6a4d186eb368a32be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/884f876e112344c6a4d186eb368a32be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/884f876e112344c6a4d186eb368a32be"}}, "title": "Interventions for treatment of COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING Project).", "authors": [{"family": "Juul", "given": "Sophie", "initials": "S", "orcid": "0000-0002-6171-2904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76a1c669d07f4d559ae43063bb008b68.json"}}, {"family": "Nielsen", "given": "Niklas", "initials": "N"}, {"family": "Bentzer", "given": "Peter", "initials": "P"}, {"family": "Veroniki", "given": "Areti Angeliki", "initials": "AA"}, {"family": "Thabane", "given": "Lehana", "initials": "L"}, {"family": "Linder", "given": "Adam", "initials": "A"}, {"family": "Klingenberg", "given": "Sarah", "initials": "S"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Jakobsen", "given": "Janus Christian", "initials": "JC"}], "type": "journal article", "published": "2020-05-09", "journal": {"title": "Syst Rev", "issn": "2046-4053", "volume": "9", "issue": "1", "pages": "108", "issn-l": null}, "abstract": "COVID-19 is a rapidly spreading virus infection that has quickly caused extensive burden to individual, families, countries, and the globe. No intervention has yet been proven effective for the treatment of COVID-19. Some randomized clinical trials assessing the effects of different drugs have been published, and more are currently underway. There is an urgent need for a living, dynamic systematic review that continuously evaluates the beneficial and harmful effects of all available interventions for COVID-19.\n\nWe will conduct a living systematic review based on searches of major medical databases (e.g., MEDLINE, EMBASE, CENTRAL) and clinical trial registries from their inception onwards to identify relevant randomized clinical trials. We will update the literature search once a week to continuously assess if new evidence is available. Two review authors will independently extract data and perform risk of bias assessment. We will include randomized clinical trials comparing any intervention for the treatment of COVID-19 (e.g., pharmacological interventions, fluid therapy, invasive or noninvasive ventilation, or similar interventions) with any comparator (e.g., an \"active\" comparator, standard care, placebo, no intervention, or \"active placebo\") for participants in all age groups with a diagnosis of COVID-19. Primary outcomes will be all-cause mortality and serious adverse events. Secondary outcomes will be admission to intensive care, mechanical ventilation, renal replacement therapy, quality of life, and non-serious adverse events. The living systematic review will include aggregate data meta-analyses, Trial Sequential Analyses, network meta-analysis, and individual patient data meta-analyses. Risk of bias will be assessed with domains, an eight-step procedure will be used to assess if the thresholds for clinical significance are crossed, and the certainty of the evidence will be assessed by Grading of Recommendations, Assessment, Development and Evaluations (GRADE).\n\nCOVID-19 has become a pandemic with substantial mortality. A living systematic review evaluating the beneficial and harmful effects of pharmacological and other interventions is urgently needed. This review will continuously inform best practice in treatment and clinical research of this highly prevalent disease.\n\nPROSPERO CRD42020178787.", "doi": "10.1186/s13643-020-01371-0", "pmid": "32386514", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13643-020-01371-0"}, {"db": "pmc", "key": "PMC7210799"}], "notes": [], "created": "2020-11-30T09:08:00.686Z", "modified": "2021-12-06T13:10:13.292Z"}, {"entity": "publication", "iuid": "0cafcc70a7c24a7ab4559b6faf5bba13", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0cafcc70a7c24a7ab4559b6faf5bba13.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0cafcc70a7c24a7ab4559b6faf5bba13"}}, "title": "Development and Potential Usefulness of the COVID-19 Ag Respi-Strip Diagnostic Assay in a Pandemic Context", "authors": [{"family": "Mertens", "given": "Pascal", "initials": "P"}, {"family": "De Vos", "given": "Nathalie", "initials": "N"}, {"family": "Martiny", "given": "Delphine", "initials": "D"}, {"family": "Jassoy", "given": "Christian", "initials": "C"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Cuypers", "given": "Lize", "initials": "L"}, {"family": "Van den Wijngaert", "given": "Sigi", "initials": "S"}, {"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Melin", "given": "Pierrette", "initials": "P"}, {"family": "Stoffels", "given": "Karolien", "initials": "K"}, {"family": "Yin", "given": "Nicolas", "initials": "N"}, {"family": "Mileto", "given": "Davide", "initials": "D"}, {"family": "Delaunoy", "given": "Sabrina", "initials": "S"}, {"family": "Magein", "given": "Henri", "initials": "H"}, {"family": "Lagrou", "given": "Katrien", "initials": "K"}, {"family": "Bouzet", "given": "Justine", "initials": "J"}, {"family": "Serrano", "given": "Gabriela", "initials": "G"}, {"family": "Wautier", "given": "Magali", "initials": "M"}, {"family": "Leclipteux", "given": "Thierry", "initials": "T"}, {"family": "Van Ranst", "given": "Marc", "initials": "M"}, {"family": "Vandenberg", "given": "Olivier", "initials": "O"}, {"family": null, "given": "", "initials": ""}], "type": "journal-article", "published": "2020-05-08", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "7", "issue": null, "pages": "225", "issn-l": null}, "abstract": "Introduction: COVID-19 Ag Respi-Strip, an immunochromatographic (ICT) assay for the rapid detection of SARS-CoV-2 antigen on nasopharyngeal specimen, has been developed to identify positive COVID-19 patients allowing prompt clinical and quarantine decisions. In this original research article, we describe the conception, the analytical and clinical performances as well as the risk management of implementing the COVID-19 Ag Respi-Strip in a diagnostic decision algorithm. Materials and Methods: Development of the COVID-19 Ag Respi-Strip resulted in a ready-to-use ICT assay based on a membrane technology with colloidal gold nanoparticles using monoclonal antibodies directed against the SARS-CoV and SARS-CoV-2 highly conserved nucleoprotein antigen. Four hundred observations were recorded for the analytical performance study and thirty tests were analyzed for the cross-reactivity study. The clinical performance study was performed in a retrospective multi-centric evaluation on aliquots of 328 nasopharyngeal samples. COVID-19 Ag Respi-Strip results were compared with qRT-PCR as golden standard for COVID-19 diagnostics. Results: In the analytical performance study, the reproducibility showed a between-observer disagreement of 1.7%, a robustness of 98%, an overall satisfying user friendliness and no cross-reactivity with other virus-infected nasopharyngeal samples. In the clinical performance study performed in three different clinical laboratories during the ascendant phase of the epidemiological curve, we found an overall sensitivity and specificity of 57.6 and 99.5%, respectively with an accuracy of 82.6%. The cut-off of the ICT was found at CT <22. User-friendliness analysis and risk management assessment through Ishikawa diagram demonstrate that COVID-19 Ag Respi-Strip may be implemented in clinical laboratories according to biosafety recommendations. Conclusion: The COVID-19 Ag Respi-Strip represents a promising rapid SARS-CoV-2 antigen assay for the first-line diagnosis of COVID-19 in 15 min at the peak of the pandemic. Its role in the proposed diagnostic algorithm is complementary to the currently-used molecular techniques.", "doi": "10.3389/fmed.2020.00225", "pmid": "32574326", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7227790"}], "notes": [], "created": "2020-12-08T16:17:00.223Z", "modified": "2021-12-06T13:09:54.471Z"}, {"entity": "publication", "iuid": "908ed23706424854b3d884aeef134258", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/908ed23706424854b3d884aeef134258.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/908ed23706424854b3d884aeef134258"}}, "title": "The Battle Against COVID-19 in Jordan: An Early Overview of the Jordanian Experience", "authors": [{"family": "Al-Tammemi", "given": "Ala'a B", "initials": "AB"}], "type": "journal-article", "published": "2020-05-07", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "188", "issn-l": "2296-2565"}, "abstract": "Since the initial spark of the COVID-19 outbreak in December 2019, which was later declared by the World Health Organization (WHO) to be a global pandemic, all affected countries are implementing various preventive and control measures to mitigate the spread of the disease. The newly emerging virus brings with it uncertainty-not only regarding its behavior and transmission dynamics but also regarding the current lack of approved antiviral therapy or vaccines-and this represents a major challenge for decision makers at various levels and sectors. This article aims to provide an early overview of the COVID-19 battle within the Jordanian context, including general reflections and conclusions on the value of collaborative efforts in crises management.", "doi": "10.3389/fpubh.2020.00188", "pmid": "32574291", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7220996"}], "notes": [], "created": "2020-12-08T16:19:43.270Z", "modified": "2021-12-06T13:09:24.624Z"}, {"entity": "publication", "iuid": "880034e9b5a34bad9a810847f9895f9a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/880034e9b5a34bad9a810847f9895f9a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/880034e9b5a34bad9a810847f9895f9a"}}, "title": "Management of COVID-19-Positive Pediatric Patients Undergoing Minimally Invasive Surgical Procedures: Systematic Review and Recommendations of the Board of European Society of Pediatric Endoscopic Surgeons", "authors": [{"family": "Pini Prato", "given": "Alessio", "initials": "A"}, {"family": "Conforti", "given": "Andrea", "initials": "A"}, {"family": "Almstrom", "given": "Markus", "initials": "M"}, {"family": "Van Gemert", "given": "Wim", "initials": "W"}, {"family": "Scuderi", "given": "Maria G", "initials": "MG"}, {"family": "Khen-Dunlop", "given": "Naziha", "initials": "N"}, {"family": "Draghici", "given": "Isabela", "initials": "I"}, {"family": "Mendoza-Sagaon", "given": "Mario", "initials": "M"}, {"family": "Gin\u00e9 Prades", "given": "Carlos", "initials": "C"}, {"family": "Chiarenza", "given": "Fabio", "initials": "F"}, {"family": "Steyaert", "given": "Henri", "initials": "H"}], "type": "journal-article", "published": "2020-05-07", "journal": {"title": "Front Pediatr", "issn": "2296-2360", "volume": "8", "issue": null, "pages": "259", "issn-l": "2296-2360"}, "abstract": "Introduction: Hospital response to the COVID-19 outbreak has involved the cancellation of elective, deferrable surgeries throughout Europe in order to ensure capacity for emergent surgery and a selection of elective but non-deferrable surgeries. The purpose of this document is to propose technical strategies to assist the pediatric surgeons to minimize the potential aerosolization of viral particles in COVID-19 patients undergoing urgent or emergent surgical treatment using laparoscopic approaches, based on the currently available literature. The situation and recommendations are subject to change with emerging information. Materials and Methods: The Scientific Committee and the Board of the European Society of Pediatric Endoscopic Surgeons gathered together in order to address the issue of minimally invasive surgery during this COVID-19 pandemic. A systematic search through PubMed, Embase, and World Wide Web of the terms \"COVID-19,\" \"Coronavirus,\" and \"SARS-CoV-2\" matched with \"pneumoperitoneum,\" \"laparoscopy,\" \"thoracoscopy,\" \"retroperitoneoscopy,\" and \"surgery\" was performed. Non-English language papers were excluded. A PRISMA report was performed. Criticalities were identified and a consensus was achieved over a number of key aspects. Results: We identified 121 documents. A total of 11 full-text documents were assessed to address all concerns related to the adoption of minimally invasive surgery. All aspect of pediatric minimally invasive surgery, including elective surgery, urgent surgery, laparoscopy, thoracoscopy, retroperitoneoscopy, and pneumoperitoneum creation and maintainance were extensively addressed through systematic review. A consensus regarding urgent laparoscopic procedures, setting and operation techniques was obtained within the Committee and the Board. Conclusions: The ESPES proposes the following recommendations in case minimally invasive surgery is needed in a COVID-19 positive pediatric patients: (1) consider conservative treatment whenever safely possible, (2) dedicate a theater, columns and reusable laparoscopic instrumentation to COVID-19 pediatric patients, (3) prefer disposable instrumentation and cables, (4) use low CO2 insufflation pressures, (5) use low power electrocautery, (6) prefer closed-systems CO2 insufflation and desufflation systems, and (7) avoid leaks through ports. These recommendations are subject to change with emerging information and might be amended in the near future.", "doi": "10.3389/fped.2020.00259", "pmid": "32550670", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7232605"}], "notes": [], "created": "2020-11-26T12:19:59.137Z", "modified": "2021-12-06T13:08:58.197Z"}, {"entity": "publication", "iuid": "86df86b0add04971b430d355b695172f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86df86b0add04971b430d355b695172f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86df86b0add04971b430d355b695172f"}}, "title": "Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?", "authors": [{"family": "Andersson", "given": "Ulf", "initials": "U", "orcid": "0000-0003-0316-3860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee9bbcb5111f446e99ff8b68c4027f5c.json"}}, {"family": "Ottestad", "given": "William", "initials": "W"}, {"family": "Tracey", "given": "Kevin J", "initials": "KJ"}], "type": "journal article", "published": "2020-05-07", "journal": {"title": "Mol Med", "issn": "1528-3658", "volume": "26", "issue": "1", "pages": "42", "issn-l": "1076-1551"}, "abstract": "The 2019 novel coronavirus disease (COVID-19) causes for unresolved reasons acute respiratory distress syndrome in vulnerable individuals. There is a need to identify key pathogenic molecules in COVID-19-associated inflammation attainable to target with existing therapeutic compounds. The endogenous damage-associated molecular pattern (DAMP) molecule HMGB1 initiates inflammation via two separate pathways. Disulfide-HMGB1 triggers TLR4 receptors generating pro-inflammatory cytokine release. Extracellular HMGB1, released from dying cells or secreted by activated innate immunity cells, forms complexes with extracellular DNA, RNA and other DAMP or pathogen-associated molecular (DAMP) molecules released after lytic cell death. These complexes are endocytosed via RAGE, constitutively expressed at high levels in the lungs only, and transported to the endolysosomal system, which is disrupted by HMGB1 at high concentrations. Danger molecules thus get access to cytosolic proinflammatory receptors instigating inflammasome activation. It is conceivable that extracellular SARS-CoV-2 RNA may reach the cellular cytosol via HMGB1-assisted transfer combined with lysosome leakage. Extracellular HMGB1 generally exists in vivo bound to other molecules, including PAMPs and DAMPs. It is plausible that these complexes are specifically removed in the lungs revealed by a 40% reduction of HMGB1 plasma levels in arterial versus venous blood. Abundant pulmonary RAGE expression enables endocytosis of danger molecules to be destroyed in the lysosomes at physiological HMGB1 levels, but causing detrimental inflammasome activation at high levels. Stress induces apoptosis in pulmonary endothelial cells from females but necrosis in cells from males.\n\nBased on these observations we propose extracellular HMGB1 to be considered as a therapeutic target for COVID-19.", "doi": "10.1186/s10020-020-00172-4", "pmid": "32380958", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s10020-020-00172-4"}, {"db": "pmc", "key": "PMC7203545"}], "notes": [], "created": "2020-11-25T07:30:42.009Z", "modified": "2021-12-06T13:08:39.901Z"}, {"entity": "publication", "iuid": "8f6f511b573945a1be8bb0f50b2f68ad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f6f511b573945a1be8bb0f50b2f68ad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f6f511b573945a1be8bb0f50b2f68ad"}}, "title": "COVID-19: a challenge for oncology services.", "authors": [{"family": "Routy", "given": "Bertrand", "initials": "B"}, {"family": "Derosa", "given": "Lisa", "initials": "L"}, {"family": "Zitvogel", "given": "Laurence", "initials": "L", "orcid": "0000-0003-1596-0998", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b10947c1a2b4884b3f502625a28c5e0.json"}}, {"family": "Kroemer", "given": "Guido", "initials": "G", "orcid": "0000-0002-9334-4405", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d17de2122d0429eaa48a733bf2ad28e.json"}}], "type": "editorial", "published": "2020-05-05", "journal": {"title": "Oncoimmunology", "issn": "2162-4011", "volume": "9", "issue": "1", "pages": "1760686", "issn-l": null}, "abstract": null, "doi": "10.1080/2162402X.2020.1760686", "pmid": "32923119", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "1760686"}, {"db": "pmc", "key": "PMC7458620"}], "notes": [], "created": "2020-12-03T15:47:32.730Z", "modified": "2021-12-06T13:07:47.749Z"}, {"entity": "publication", "iuid": "01fac03dcd13402b921d766ed13344f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01fac03dcd13402b921d766ed13344f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01fac03dcd13402b921d766ed13344f4"}}, "title": "Digesting the crisis: autophagy and coronaviruses.", "authors": [{"family": "Carmona-Gutierrez", "given": "Didac", "initials": "D"}, {"family": "Bauer", "given": "Maria A", "initials": "MA"}, {"family": "Zimmermann", "given": "Andreas", "initials": "A"}, {"family": "Kainz", "given": "Katharina", "initials": "K"}, {"family": "Hofer", "given": "Sebastian J", "initials": "SJ"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}, {"family": "Madeo", "given": "Frank", "initials": "F"}], "type": "journal article", "published": "2020-05-04", "journal": {"title": "Microb Cell", "issn": "2311-2638", "volume": "7", "issue": "5", "pages": "119-128", "issn-l": "2311-2638"}, "abstract": "Autophagy is a catabolic pathway with multifaceted roles in cellular homeostasis. This process is also involved in the antiviral response at multiple levels, including the direct elimination of intruding viruses (virophagy), the presentation of viral antigens, the fitness of immune cells, and the inhibition of excessive inflammatory reactions. In line with its central role in immunity, viruses have evolved mechanisms to interfere with or to evade the autophagic process, and in some cases, even to harness autophagy or constituents of the autophagic machinery for their replication. Given the devastating consequences of the current COVID-19 pandemic, the question arises whether manipulating autophagy might be an expedient approach to fight the novel coronavirus SARS-CoV-2. In this piece, we provide a short overview of the evidence linking autophagy to coronaviruses and discuss whether such links may provide actionable targets for therapeutic interventions.", "doi": "10.15698/mic2020.05.715", "pmid": "32391393", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "MIC0270E122"}, {"db": "pmc", "key": "PMC7199282"}], "notes": [], "created": "2020-11-25T07:58:17.099Z", "modified": "2021-12-06T13:06:40.272Z"}, {"entity": "publication", "iuid": "b405175e46c046df86d6925d657f3ed8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b405175e46c046df86d6925d657f3ed8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b405175e46c046df86d6925d657f3ed8"}}, "title": "A united statement of the global chiropractic research community against the pseudoscientific claim that chiropractic care boosts immunity.", "authors": [{"family": "C\u00f4t\u00e9", "given": "Pierre", "initials": "P"}, {"family": "Bussi\u00e8res", "given": "Andr\u00e9", "initials": "A"}, {"family": "Cassidy", "given": "J David", "initials": "JD"}, {"family": "Hartvigsen", "given": "Jan", "initials": "J"}, {"family": "Kawchuk", "given": "Greg N", "initials": "GN"}, {"family": "Leboeuf-Yde", "given": "Charlotte", "initials": "C"}, {"family": "Mior", "given": "Silvano", "initials": "S"}, {"family": "Schneider", "given": "Michael", "initials": "M"}, {"family": "140 signatories# call for an end to pseudoscientific claims on the effect of chiropractic care on immune function", "given": "", "initials": ""}], "type": "journal article", "published": "2020-05-04", "journal": {"title": "Chiropr Man Therap", "issn": "2045-709X", "volume": "28", "issue": "1", "pages": "21", "issn-l": "2045-709X"}, "abstract": "In the midst of the coronavirus pandemic, the International Chiropractors Association (ICA) posted reports claiming that chiropractic care can impact the immune system. These claims clash with recommendations from the World Health Organization and World Federation of Chiropractic. We discuss the scientific validity of the claims made in these ICA reports.\n\nWe reviewed the two reports posted by the ICA on their website on March 20 and March 28, 2020. We explored the method used to develop the claim that chiropractic adjustments impact the immune system and discuss the scientific merit of that claim. We provide a response to the ICA reports and explain why this claim lacks scientific credibility and is dangerous to the public. More than 150 researchers from 11 countries reviewed and endorsed our response.\n\nIn their reports, the ICA provided no valid clinical scientific evidence that chiropractic care can impact the immune system. We call on regulatory authorities and professional leaders to take robust political and regulatory action against those claiming that chiropractic adjustments have a clinical impact on the immune system.", "doi": "10.1186/s12998-020-00312-x", "pmid": "32366319", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12998-020-00312-x"}, {"db": "pmc", "key": "PMC7197358"}], "notes": [], "created": "2020-11-25T07:24:09.543Z", "modified": "2021-12-06T13:06:22.682Z"}, {"entity": "publication", "iuid": "5325440967464cc29a380ee219699347", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5325440967464cc29a380ee219699347.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5325440967464cc29a380ee219699347"}}, "title": "Preventing spread of SARS-CoV-2 and preparing for the COVID-19 outbreak in the surgical department: perspectives from two Scandinavian countries", "authors": [{"family": "Lindeman", "given": "Robbert Jan", "initials": "RJ"}, {"family": "Sund", "given": "Malin", "initials": "M"}, {"family": "L\u00f6fgren", "given": "Jenny", "initials": "J"}, {"family": "Basso", "given": "Trude", "initials": "T"}, {"family": "S\u00f8reide", "given": "Kjetil", "initials": "K", "orcid": "0000-0001-7594-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9c5655fc6aa437d91ed5cc2b4791543.json"}}], "type": "journal-article", "published": "2020-05-01", "journal": {"title": "J Surg Case Rep", "issn": "2042-8812", "issn-l": "2042-8812", "volume": "2020", "issue": "5", "pages": "rjaa131"}, "abstract": "A COVID-19 pandemic was declared on March 11 by the World Health Organization (WHO). The first cases of COVID-19 were confirmed on January 31 in Sweden and on February 26 in Norway. Despite being similar countries with universal healthcare systems, the governmental approaches to mitigation of the epidemic have varied considerably. Norway initiated a societal lockdown effective from March 12, the same day as the first confirmed death. Sweden has initiated a more laxed and gradual strategy based on the appeal for a strong personal sense of responsibility to mitigate the viral spread. In both countries, the first weeks of preparation has seen a strong reduction in elective surgery, with several implemented principles to mitigate SARS-CoV-2 spread and prepare for surgical care for COVID-19 diseases as needed. This invited leading article gives a brief overview of some of the early experiences of the outbreak in two Scandinavian countries.", "doi": "10.1093/jscr/rjaa131", "pmid": "32395226", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "rjaa131"}, {"db": "pmc", "key": "PMC7202331"}], "notes": [], "created": "2020-11-25T07:59:03.840Z", "modified": "2021-12-06T13:04:20.843Z"}, {"entity": "publication", "iuid": "4d4cde731a184da8be9ae3d417ecb902", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4d4cde731a184da8be9ae3d417ecb902.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4d4cde731a184da8be9ae3d417ecb902"}}, "title": "Dysregulation in mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells", "authors": [{"family": "Appelberg", "given": "Sofia", "initials": "S"}, {"family": "Gupta", "given": "Soham", "initials": "S"}, {"family": "Ambikan", "given": "Anoop T", "initials": "AT"}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "V\u00e9gv\u00e1ri", "given": "\u00c1kos", "initials": "\u00c1"}, {"family": "Akusj\u00e4rvi", "given": "Sara Svensson", "initials": "SS"}, {"family": "Benfeitas", "given": "Rui", "initials": "R"}, {"family": "Sperk", "given": "Maike", "initials": "M"}, {"family": "St\u00e5hlberg", "given": "Marie", "initials": "M"}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Singh", "given": "Kamal", "initials": "K"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "posted-content", "published": "2020-05-01", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.04.30.070383", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-14T14:58:17.708Z", "modified": "2021-12-06T13:06:02.092Z"}, {"entity": "publication", "iuid": "aef310ad68884b00ad09dff6ca327828", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aef310ad68884b00ad09dff6ca327828.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aef310ad68884b00ad09dff6ca327828"}}, "title": "What does COVID\u201019 distract us from? A migration studies perspective on the inequities of attention", "authors": [{"family": "Della Rosa", "given": "Asia", "initials": "A", "orcid": "0000-0002-2604-0284", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93497b0315174b4697d5b15e56cd656c.json"}}, {"family": "Goldstein", "given": "Asher", "initials": "A", "orcid": "0000-0003-4314-9596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52c678422cb34e36a9974fc180fa6b13.json"}}], "type": "journal-article", "published": "2020-05-00", "journal": {"title": "Soc Anthropol", "issn": "1469-8676", "volume": "28", "issue": "2", "pages": "257-259", "issn-l": null}, "abstract": null, "doi": "10.1111/1469-8676.12899", "pmid": "32836948", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "SOCA12899"}, {"db": "pmc", "key": "PMC7276791"}], "notes": [], "created": "2020-12-07T10:37:28.561Z", "modified": "2021-12-06T13:15:35.718Z"}, {"entity": "publication", "iuid": "fc4e079187234aeaa3ba585e6cbd4fd7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc4e079187234aeaa3ba585e6cbd4fd7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc4e079187234aeaa3ba585e6cbd4fd7"}}, "title": "The Need of Research Initiatives Amidst and After the Covid-19 Pandemic: A Message from the Editors of the EJVES", "authors": [{"family": "Bj\u00f6rck", "given": "Martin", "initials": "M"}, {"family": "Boyle", "given": "Jonathan R", "initials": "JR"}, {"family": "Dick", "given": "Florian", "initials": "F"}], "type": "journal-article", "published": "2020-05-00", "journal": {"title": "Eur J Vasc Endovasc Surg", "issn": "1078-5884", "volume": "59", "issue": "5", "pages": "695-696", "issn-l": null}, "abstract": "Editorial", "doi": "10.1016/j.ejvs.2020.04.002", "pmid": "32303451", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1078-5884(20)30324-5"}, {"db": "pmc", "key": "PMC7151378"}], "notes": [], "created": "2020-11-22T08:52:45.922Z", "modified": "2021-12-06T13:05:35.086Z"}, {"entity": "publication", "iuid": "0c478d1d514d4c4b9f631e9223d724b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c478d1d514d4c4b9f631e9223d724b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c478d1d514d4c4b9f631e9223d724b0"}}, "title": "Saliva testing for COVID-19?", "authors": [{"family": "Sapkota", "given": "D", "initials": "D"}, {"family": "Thapa", "given": "S B", "initials": "SB"}, {"family": "Hass\u00e9us", "given": "B", "initials": "B"}, {"family": "Jensen", "given": "J L", "initials": "JL"}], "type": "journal-article", "published": "2020-05-00", "journal": {"title": "Br Dent J", "issn": "1476-5373", "volume": "228", "issue": "9", "pages": "658-659", "issn-l": null}, "abstract": null, "doi": "10.1038/s41415-020-1594-7", "pmid": "32385433", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41415-020-1594-7"}], "notes": [], "created": "2020-12-10T07:41:02.939Z", "modified": "2021-12-06T13:05:14.408Z"}, {"entity": "publication", "iuid": "799fba058334420eb8a7605051fb1b71", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/799fba058334420eb8a7605051fb1b71.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/799fba058334420eb8a7605051fb1b71"}}, "title": "Protecting children in low-income and middle-income countries from COVID-19", "authors": [{"family": "Ahmed", "given": "Salahuddin", "initials": "S", "orcid": "0000-0001-6771-0638", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36afb59c938e4bc8bbcaf428373622c4.json"}}, {"family": "Mvalo", "given": "Tisungane", "initials": "T"}, {"family": "Akech", "given": "Samuel", "initials": "S"}, {"family": "Agweyu", "given": "Ambrose", "initials": "A"}, {"family": "Baker", "given": "Kevin", "initials": "K"}, {"family": "Bar-Zeev", "given": "Naor", "initials": "N"}, {"family": "Campbell", "given": "Harry", "initials": "H"}, {"family": "Checkley", "given": "William", "initials": "W"}, {"family": "Chisti", "given": "Mohammod Jobayer", "initials": "MJ"}, {"family": "Colbourn", "given": "Tim", "initials": "T", "orcid": "0000-0002-6917-6552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2cccce75e4b4602ab197604cb444a0a.json"}}, {"family": "Cunningham", "given": "Steve", "initials": "S"}, {"family": "Duke", "given": "Trevor", "initials": "T"}, {"family": "English", "given": "Mike", "initials": "M", "orcid": "0000-0002-7427-0826", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d680cdafc8854a619f1919652dd16aed.json"}}, {"family": "Falade", "given": "Adegoke G", "initials": "AG"}, {"family": "Fancourt", "given": "Nicholas SS", "initials": "NS", "orcid": "0000-0002-1772-9960", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5c4d94e20e74d02a6ee3f4287e0d588.json"}}, {"family": "Ginsburg", "given": "Amy S", "initials": "AS"}, {"family": "Graham", "given": "Hamish R", "initials": "HR", "orcid": "0000-0003-2461-0463", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d2d23d0b7dc40f3979a4342d3898649.json"}}, {"family": "Gray", "given": "Diane M", "initials": "DM"}, {"family": "Gupta", "given": "Madhu", "initials": "M"}, {"family": "Hammitt", "given": "Laura", "initials": "L"}, {"family": "Hesseling", "given": "Anneke C", "initials": "AC"}, {"family": "Hooli", "given": "Shubhada", "initials": "S", "orcid": "0000-0003-4596-448X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20d63548cf4340a2a8e3d092113580d7.json"}}, {"family": "Johnson", "given": "Abdul Wahab BR", "initials": "AWB"}, {"family": "King", "given": "Carina", "initials": "C"}, {"family": "Kirby", "given": "Miles A", "initials": "MA"}, {"family": "Lanata", "given": "Claudio F", "initials": "CF"}, {"family": "Lufesi", "given": "Norman", "initials": "N"}, {"family": "Mackenzie", "given": "Grant A", "initials": "GA"}, {"family": "McCracken", "given": "John P", "initials": "JP"}, {"family": "Moschovis", "given": "Peter P", "initials": "PP", "orcid": "0000-0002-9664-5959", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5df313713eda423196bc8f01c3cccd6a.json"}}, {"family": "Nair", "given": "Harish", "initials": "H"}, {"family": "Oviawe", "given": "Osawaru", "initials": "O"}, {"family": "Pomat", "given": "William S", "initials": "WS"}, {"family": "Santosham", "given": "Mathuram", "initials": "M"}, {"family": "Seddon", "given": "James A", "initials": "JA"}, {"family": "Thahane", "given": "Lineo Keneuoe", "initials": "LK"}, {"family": "Wahl", "given": "Brian", "initials": "B", "orcid": "0000-0002-0037-7364", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a1b355e68f949a3964fac2381982327.json"}}, {"family": "Van der Zalm", "given": "Marieke", "initials": "M"}, {"family": "Verwey", "given": "Charl", "initials": "C"}, {"family": "Yoshida", "given": "Lay Myint", "initials": "LM"}, {"family": "Zar", "given": "Heather J", "initials": "HJ"}, {"family": "Howie", "given": "Stephen RC", "initials": "SR"}, {"family": "McCollum", "given": "Eric D", "initials": "ED", "orcid": "0000-0002-1872-5566", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/95a0edabce86477287b3354ea4861a33.json"}}], "type": "journal-article", "published": "2020-05-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "5", "issue": "5", "pages": "e002844", "issn-l": "2059-7908"}, "abstract": "Editorial", "doi": "10.1136/bmjgh-2020-002844", "pmid": "32461228", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-002844"}, {"db": "pmc", "key": "PMC7254117"}], "notes": [], "created": "2020-11-25T09:21:02.315Z", "modified": "2021-12-06T13:04:54.117Z"}, {"entity": "publication", "iuid": "a25c8dcffb2040b787a0f1d3621f4dce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a25c8dcffb2040b787a0f1d3621f4dce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a25c8dcffb2040b787a0f1d3621f4dce"}}, "title": "Practice recommendations for lung cancer radiotherapy during the COVID-19 pandemic: An ESTRO-ASTRO consensus statement.", "authors": [{"family": "Guckenberger", "given": "Matthias", "initials": "M", "orcid": "0000-0002-7146-9071", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09684c7ae622448f99208130af9e282e.json"}}, {"family": "Belka", "given": "Claus", "initials": "C"}, {"family": "Bezjak", "given": "Andrea", "initials": "A"}, {"family": "Bradley", "given": "Jeffrey", "initials": "J"}, {"family": "Daly", "given": "Megan E", "initials": "ME", "orcid": "0000-0001-7308-6149", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc0b3418cf5d4e1897814f629298d06e.json"}}, {"family": "DeRuysscher", "given": "Dirk", "initials": "D"}, {"family": "Dziadziuszko", "given": "Rafal", "initials": "R", "orcid": "0000-0001-8080-9843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e81c6277a79c41bca7fa5d9a83bc4e6e.json"}}, {"family": "Faivre-Finn", "given": "Corinne", "initials": "C", "orcid": "0000-0001-5617-9781", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e12bb7f823e74c3bb7e16a73b04d594c.json"}}, {"family": "Flentje", "given": "Michael", "initials": "M"}, {"family": "Gore", "given": "Elizabeth", "initials": "E"}, {"family": "Higgins", "given": "Kristin A", "initials": "KA"}, {"family": "Iyengar", "given": "Puneeth", "initials": "P"}, {"family": "Kavanagh", "given": "Brian D", "initials": "BD", "orcid": "0000-0001-5579-1725", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7c5b8b6b8804b22896a1d2efcca9285.json"}}, {"family": "Kumar", "given": "Sameera", "initials": "S"}, {"family": "Le Pechoux", "given": "Cecile", "initials": "C"}, {"family": "Lievens", "given": "Yolande", "initials": "Y"}, {"family": "Lindberg", "given": "Karin", "initials": "K"}, {"family": "McDonald", "given": "Fiona", "initials": "F"}, {"family": "Ramella", "given": "Sara", "initials": "S"}, {"family": "Rengan", "given": "Ramesh", "initials": "R", "orcid": "0000-0001-5379-536X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6006bff18bfe4dd38cce342cf4008e28.json"}}, {"family": "Ricardi", "given": "Umberto", "initials": "U", "orcid": "0000-0003-4406-7621", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4592c02990ab440790e7391977331369.json"}}, {"family": "Rimner", "given": "Andreas", "initials": "A"}, {"family": "Rodrigues", "given": "George B", "initials": "GB"}, {"family": "Schild", "given": "Steven E", "initials": "SE"}, {"family": "Senan", "given": "Suresh", "initials": "S"}, {"family": "Simone", "given": "Charles B", "initials": "CB 2nd"}, {"family": "Slotman", "given": "Ben J", "initials": "BJ", "orcid": "0000-0002-9902-4592", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c53ea83c8d964c08b08ec6efe7d782cb.json"}}, {"family": "Stuschke", "given": "Martin", "initials": "M"}, {"family": "Videtic", "given": "Greg", "initials": "G"}, {"family": "Widder", "given": "Joachim", "initials": "J", "orcid": "0000-0002-9972-6690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12f78661cf184d809e1208fdb742cdbb.json"}}, {"family": "Yom", "given": "Sue S", "initials": "SS", "orcid": "0000-0002-0779-7476", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dcd04dd7ffd94ac79534245657af08ca.json"}}, {"family": "Palma", "given": "David", "initials": "D", "orcid": "0000-0002-9542-0627", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c33cf08374fb445887d22f67b62f1792.json"}}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "Radiother Oncol", "issn": "1879-0887", "volume": "146", "issue": null, "pages": "223-229", "issn-l": "0167-8140"}, "abstract": "The COVID-19 pandemic has caused radiotherapy resource pressures and led to increased risks for lung cancer patients and healthcare staff. An international group of experts in lung cancer radiotherapy established this practice recommendation pertaining to whether and how to adapt radiotherapy for lung cancer in the COVID-19 pandemic.\n\nFor this ESTRO & ASTRO endorsed project, 32 experts in lung cancer radiotherapy contributed to a modified Delphi consensus process. We assessed potential adaptations of radiotherapy in two pandemic scenarios. The first, an early pandemic scenario of risk mitigation, is characterized by an altered risk-benefit ratio of radiotherapy for lung cancer patients due to their increased susceptibility for severe COVID-19 infection, and minimization of patient travelling and exposure of radiotherapy staff. The second, a later pandemic scenario, is characterized by reduced radiotherapy resources requiring patient triage. Six common lung cancer cases were assessed for both scenarios: peripherally located stage I NSCLC, locally advanced NSCLC, postoperative radiotherapy after resection of pN2 NSCLC, thoracic radiotherapy and prophylactic cranial irradiation for limited stage SCLC and palliative thoracic radiotherapy for stage IV NSCLC.\n\nIn a risk-mitigation pandemic scenario, efforts should be made not to compromise the prognosis of lung cancer patients by departing from guideline-recommended radiotherapy practice. In that same scenario, postponement or interruption of radiotherapy treatment of COVID-19 positive patients is generally recommended to avoid exposure of cancer patients and staff to an increased risk of COVID-19 infection. In a severe pandemic scenario characterized by reduced resources, if patients must be triaged, important factors for triage include potential for cure, relative benefit of radiation, life expectancy, and performance status. Case-specific consensus recommendations regarding multimodality treatment strategies and fractionation of radiotherapy are provided.\n\nThis joint ESTRO-ASTRO practice recommendation established pragmatic and balanced consensus recommendations in common clinical scenarios of radiotherapy for lung cancer in order to address the challenges of the COVID-19 pandemic.", "doi": "10.1016/j.radonc.2020.04.001", "pmid": "32342863", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0167-8140(20)30182-1"}, {"db": "pmc", "key": "PMC7252074"}], "notes": [], "created": "2020-11-25T07:13:12.107Z", "modified": "2021-12-06T13:03:46.407Z"}, {"entity": "publication", "iuid": "d0ce868b1d99450081c6108a163f3209", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d0ce868b1d99450081c6108a163f3209.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d0ce868b1d99450081c6108a163f3209"}}, "title": "Managing COVID-19 in the oncology clinic and avoiding the distraction effect.", "authors": [{"family": "Cortiula", "given": "F", "initials": "F"}, {"family": "Pettke", "given": "A", "initials": "A"}, {"family": "Bartoletti", "given": "M", "initials": "M"}, {"family": "Puglisi", "given": "F", "initials": "F"}, {"family": "Helleday", "given": "T", "initials": "T"}], "type": "editorial", "published": "2020-05-00", "journal": {"title": "Annals of Oncology", "issn": "1569-8041", "volume": "31", "issue": "5", "pages": "553-555", "issn-l": "0923-7534"}, "abstract": null, "doi": "10.1016/j.annonc.2020.03.286", "pmid": "32201224", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0923-7534(20)36373-0"}, {"db": "pmc", "key": "PMC7174827"}], "notes": [], "created": "2020-11-04T13:17:26.873Z", "modified": "2021-12-06T13:03:18.096Z"}, {"entity": "publication", "iuid": "915fc7aead7f44f0b92cddf6e2657588", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/915fc7aead7f44f0b92cddf6e2657588.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/915fc7aead7f44f0b92cddf6e2657588"}}, "title": "Management of Advanced Therapies in Parkinson's Disease Patients in Times of Humanitarian Crisis: The COVID-19 Experience.", "authors": [{"family": "Fasano", "given": "Alfonso", "initials": "A"}, {"family": "Antonini", "given": "Angelo", "initials": "A"}, {"family": "Katzenschlager", "given": "Regina", "initials": "R"}, {"family": "Krack", "given": "Paul", "initials": "P"}, {"family": "Odin", "given": "Per", "initials": "P"}, {"family": "Evans", "given": "Andrew H", "initials": "AH"}, {"family": "Foltynie", "given": "Thomas", "initials": "T"}, {"family": "Volkmann", "given": "Jens", "initials": "J"}, {"family": "Merello", "given": "Marcelo", "initials": "M"}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "Mov Disord Clin Pract", "issn": "2330-1619", "volume": "7", "issue": "4", "pages": "361-372", "issn-l": null}, "abstract": "Although the COVID-19 pandemic is affecting a relatively small proportion of the global population, its effects have already reached everyone. The pandemic has the potential to differentially disadvantage chronically ill patients, including those with Parkinson's disease (PD). The first health care reaction has been to limit access to clinics and neurology wards to preserve fragile patients with PD from being infected. In some regions, the shortage of medical staff has also forced movement disorders neurologists to provide care for patients with COVID-19.\n\nTo share the experience of various movement disorder neurologists operating in different world regions and provide a common approach to patients with PD, with a focus on those already on advanced therapies, which may serve as guidance in the current pandemic and for emergency situations that we may face in the future.\n\nMost of us were unprepared to deal with this condition given that in many health care systems, telemedicine has been only marginally available or only limited to email or telephone contacts. In addition, to ensure sufficient access to intensive care unit beds, most elective procedures (including deep brain stimulation or the initiation of infusion therapies) have been postponed. We all hope there will soon be a time when we will return to more regular hospital schedules. However, we should consider this crisis as an opportunity to change our approach and encourage our hospitals and health care systems to facilitate the remote management of chronic neurological patients, including those with advanced PD.", "doi": "10.1002/mdc3.12965", "pmid": "32373652", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "MDC312965"}, {"db": "pmc", "key": "PMC7197306"}], "notes": [], "created": "2020-12-10T07:32:13.596Z", "modified": "2020-12-10T07:32:13.608Z"}, {"entity": "publication", "iuid": "6880115da67342c8aee2da2101ee00ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6880115da67342c8aee2da2101ee00ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6880115da67342c8aee2da2101ee00ee"}}, "title": "ISUOG Safety Committee Position Statement on safe performance of obstetric and gynecological scans and equipment cleaning in context of COVID-19.", "authors": [{"family": "Poon", "given": "L C", "initials": "LC"}, {"family": "Abramowicz", "given": "J S", "initials": "JS"}, {"family": "Dall'Asta", "given": "A", "initials": "A"}, {"family": "Sande", "given": "R", "initials": "R"}, {"family": "Ter Haar", "given": "G", "initials": "G"}, {"family": "Mar\u0161al", "given": "K", "initials": "K"}, {"family": "Brezinka", "given": "C", "initials": "C"}, {"family": "Miloro", "given": "P", "initials": "P"}, {"family": "Basseal", "given": "J", "initials": "J"}, {"family": "Westerway", "given": "S C", "initials": "SC"}, {"family": "Abu-Rustum", "given": "R S", "initials": "RS"}, {"family": "Lees", "given": "C", "initials": "C"}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "Ultrasound Obstet Gynecol", "issn": "1469-0705", "volume": "55", "issue": "5", "pages": "709-712", "issn-l": null}, "abstract": null, "doi": "10.1002/uog.22027", "pmid": "32207189", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-08T06:57:10.479Z", "modified": "2020-12-10T08:59:30.636Z"}, {"entity": "publication", "iuid": "6da4506c756d45aa94417f1e53816578", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6da4506c756d45aa94417f1e53816578.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6da4506c756d45aa94417f1e53816578"}}, "title": "D\u00e9j\u00e0 vu: Stimulating open drug discovery for SARS-CoV-2.", "authors": [{"family": "Ekins", "given": "Sean", "initials": "S"}, {"family": "Mottin", "given": "Melina", "initials": "M"}, {"family": "Ramos", "given": "Paulo R P S", "initials": "PRPS"}, {"family": "Sousa", "given": "Bruna K P", "initials": "BKP"}, {"family": "Neves", "given": "Bruno Junior", "initials": "BJ"}, {"family": "Foil", "given": "Daniel H", "initials": "DH"}, {"family": "Zorn", "given": "Kimberley M", "initials": "KM"}, {"family": "Braga", "given": "Rodolpho C", "initials": "RC"}, {"family": "Coffee", "given": "Megan", "initials": "M"}, {"family": "Southan", "given": "Christopher", "initials": "C"}, {"family": "Puhl", "given": "Ana C", "initials": "AC"}, {"family": "Andrade", "given": "Carolina Horta", "initials": "CH"}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "Drug Discov Today", "issn": "1878-5832", "volume": "25", "issue": "5", "pages": "928-941", "issn-l": null}, "abstract": "In the past decade we have seen two major Ebola virus outbreaks in Africa, the Zika virus in Brazil and the Americas and the current pandemic of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There is a strong sense of d\u00e9j\u00e0 vu because there are still no effective treatments. In the COVID-19 pandemic, despite being a new virus, there are already drugs suggested as active in in vitro assays that are being repurposed in clinical trials. Promising SARS-CoV-2 viral targets and computational approaches are described and discussed. Here, we propose, based on open antiviral drug discovery approaches for previous outbreaks, that there could still be gaps in our approach to drug discovery.", "doi": "10.1016/j.drudis.2020.03.019", "pmid": "32320852", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1359-6446(20)30145-8"}, {"db": "pmc", "key": "PMC7167229"}], "notes": [], "created": "2020-11-30T15:55:34.499Z", "modified": "2020-11-30T15:55:34.523Z"}, {"entity": "publication", "iuid": "66b254f7d31346739b916455b018cd88", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66b254f7d31346739b916455b018cd88.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66b254f7d31346739b916455b018cd88"}}, "title": "Could severe COVID-19 be considered a complementopathy?", "authors": [{"family": "Chatzidionysiou", "given": "Katerina", "initials": "K", "orcid": "0000-0002-2669-1247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5cbb9ca8214426084a1def47e9029b2.json"}}, {"family": "Svenungsson", "given": "Elisabet", "initials": "E"}, {"family": "Faustini", "given": "Francesca", "initials": "F"}], "type": "journal-article", "published": "2020-05-00", "journal": {"title": "Lupus Sci Med", "issn": "2053-8790", "volume": "7", "issue": "1", "pages": "e000415", "issn-l": "2053-8790"}, "abstract": null, "doi": "10.1136/lupus-2020-000415", "pmid": "32430402", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "7/1/e000415"}, {"db": "pmc", "key": "PMC7246101"}], "notes": [], "created": "2020-11-25T09:07:20.316Z", "modified": "2021-12-06T13:01:45.301Z"}, {"entity": "publication", "iuid": "ee1e8b1ebe574af7a398a7a45d56a825", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee1e8b1ebe574af7a398a7a45d56a825.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee1e8b1ebe574af7a398a7a45d56a825"}}, "title": "Classification system and case definition for SARS-CoV-2 infection in pregnant women, fetuses, and neonates.", "authors": [{"family": "Shah", "given": "Prakesh S", "initials": "PS"}, {"family": "Diambomba", "given": "Yenge", "initials": "Y"}, {"family": "Acharya", "given": "Ganesh", "initials": "G"}, {"family": "Morris", "given": "Shaun K", "initials": "SK"}, {"family": "Bitnun", "given": "Ari", "initials": "A"}], "type": "editorial", "published": "2020-05-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "5", "pages": "565-568", "issn-l": "0001-6349"}, "abstract": null, "doi": "10.1111/aogs.13870", "pmid": "32277845", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7262318"}], "notes": [], "created": "2020-11-23T11:28:46.202Z", "modified": "2020-12-09T14:48:38.570Z"}, {"entity": "publication", "iuid": "63e8720413dc48c5b2a905b7a43ef905", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63e8720413dc48c5b2a905b7a43ef905.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63e8720413dc48c5b2a905b7a43ef905"}}, "title": "Caring for patients with cancer in the COVID-19 era.", "authors": [{"family": "van de Haar", "given": "Joris", "initials": "J"}, {"family": "Hoes", "given": "Louisa R", "initials": "LR"}, {"family": "Coles", "given": "Charlotte E", "initials": "CE"}, {"family": "Seamon", "given": "Kenneth", "initials": "K"}, {"family": "Fr\u00f6hling", "given": "Stefan", "initials": "S"}, {"family": "J\u00e4ger", "given": "Dirk", "initials": "D"}, {"family": "Valenza", "given": "Franco", "initials": "F"}, {"family": "de Braud", "given": "Filippo", "initials": "F"}, {"family": "De Petris", "given": "Luigi", "initials": "L"}, {"family": "Bergh", "given": "Jonas", "initials": "J"}, {"family": "Ernberg", "given": "Ingemar", "initials": "I"}, {"family": "Besse", "given": "Benjamin", "initials": "B"}, {"family": "Barlesi", "given": "Fabrice", "initials": "F"}, {"family": "Garralda", "given": "Elena", "initials": "E"}, {"family": "Piris-Gim\u00e9nez", "given": "Alejandro", "initials": "A"}, {"family": "Baumann", "given": "Michael", "initials": "M"}, {"family": "Apolone", "given": "Giovanni", "initials": "G"}, {"family": "Soria", "given": "Jean Charles", "initials": "JC"}, {"family": "Tabernero", "given": "Josep", "initials": "J"}, {"family": "Caldas", "given": "Carlos", "initials": "C"}, {"family": "Voest", "given": "Emile E", "initials": "EE"}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "volume": "26", "issue": "5", "pages": "665-671", "issn-l": "1078-8956"}, "abstract": "The current COVID-19 pandemic challenges oncologists to profoundly re-organize oncological care in order to dramatically reduce hospital visits and admissions and therapy-induced immune-related complications without compromising cancer outcomes. Since COVID-19 is a novel disease, guidance by scientific evidence is often unavailable, and impactful decisions are inevitably made on the basis of expert opinions. Here we report how the seven comprehensive cancer centers of Cancer Core Europe have organized their healthcare systems at an unprecedented scale and pace to make their operations 'pandemic proof'. We identify and discuss many commonalities, but also important local differences, and pinpoint critical research priorities to enable evidence-based remodeling of cancer care during the COVID-19 pandemic. Also, we discuss how the current situation offers a unique window of opportunity for assessing the effects of de-escalating anticancer regimens, which may fast-forward the development of more-refined and less-toxic treatments. By sharing our joint experiences, we offer a roadmap for proceeding and aim to mobilize the global research community to generate the data that are critically needed to offer the best possible care to patients.", "doi": "10.1038/s41591-020-0874-8", "pmid": "32405058", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-020-0874-8"}], "notes": [], "created": "2020-11-25T08:02:57.207Z", "modified": "2020-11-30T09:07:56.925Z"}, {"entity": "publication", "iuid": "0c354790c7ff4f10b5b8a21467a49ea5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c354790c7ff4f10b5b8a21467a49ea5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c354790c7ff4f10b5b8a21467a49ea5"}}, "title": "Burden and prevalence of prognostic factors for severe COVID-19 in Sweden.", "authors": [{"family": "G\u00e9mes", "given": "Katalin", "initials": "K", "orcid": "0000-0003-3335-7850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe866acb6ee744e7a413be9348fd3463.json"}}, {"family": "Talb\u00e4ck", "given": "Mats", "initials": "M"}, {"family": "Modig", "given": "Karin", "initials": "K"}, {"family": "Ahlbom", "given": "Anders", "initials": "A"}, {"family": "Berglund", "given": "Anita", "initials": "A"}, {"family": "Feychting", "given": "Maria", "initials": "M"}, {"family": "Matthews", "given": "Anthony A", "initials": "AA", "orcid": "0000-0002-1290-271X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8d087bad1264a57b5e9d6e3c264bf21.json"}}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "Eur J Epidemiol", "issn": "1573-7284", "issn-l": "0393-2990", "volume": "35", "issue": "5", "pages": "401-409"}, "abstract": "The World Health Organization and European Centre for Disease Prevention and Control suggest that individuals over the age of 70 years or with underlying cardiovascular disease, cancer, chronic obstructive pulmonary disease, asthma, or diabetes are at increased risk of severe COVID-19. However, the prevalence of these prognostic factors is unknown in many countries. We aimed to describe the burden and prevalence of prognostic factors of severe COVID-19 at national and county level in Sweden. We calculated the burden and prevalence of prognostic factors for severe COVID-19 based on records from the Swedish national health care and population registers for 3 years before 1st January 2016. 9,624,428 individuals were included in the study population. 22.1% had at least one prognostic factor for severe COVID-19 (2,131,319 individuals), and 1.6% had at least three factors (154,746 individuals). The prevalence of underlying medical conditions ranged from 0.8% with chronic obstructive pulmonary disease (78,516 individuals) to 7.4% with cardiovascular disease (708,090 individuals), and the county specific prevalence of at least one prognostic factor ranged from 19.2% in Stockholm (416,988 individuals) to 25.9% in Kalmar (60,005 individuals). We show that one in five individuals in Sweden is at increased risk of severe COVID-19. When compared with the critical care capacity at a local and national level, these results can aid authorities in optimally planning healthcare resources during the current pandemic. Findings can also be applied to underlying assumptions of disease burden in modelling efforts to support COVID-19 planning.", "doi": "10.1007/s10654-020-00646-z", "pmid": "32424571", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7233678"}, {"db": "pii", "key": "10.1007/s10654-020-00646-z"}], "notes": [], "created": "2021-06-14T06:37:37.102Z", "modified": "2023-06-19T14:52:50.448Z"}, {"entity": "publication", "iuid": "5506caef258d4d358aebefa4269ad746", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5506caef258d4d358aebefa4269ad746.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5506caef258d4d358aebefa4269ad746"}}, "title": "Allergic respiratory disease care in the COVID-19 era: A EUFOREA statement.", "authors": [{"family": "Scadding", "given": "Glenis K", "initials": "GK"}, {"family": "Hellings", "given": "Peter W", "initials": "PW"}, {"family": "Bachert", "given": "Claus", "initials": "C"}, {"family": "Bjermer", "given": "Leif", "initials": "L"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}, {"family": "Gevaert", "given": "Philippe", "initials": "P"}, {"family": "Kjeldsen", "given": "Anette", "initials": "A"}, {"family": "Kleine-Tebbe", "given": "Jorge", "initials": "J"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Muraro", "given": "Antonella", "initials": "A"}, {"family": "Roberts", "given": "Graham", "initials": "G"}, {"family": "Steinsvik", "given": "Andreas", "initials": "A"}, {"family": "Wagenmann", "given": "Martin", "initials": "M"}, {"family": "Wahn", "given": "Ulrich", "initials": "U"}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "World Allergy Organ J", "issn": "1939-4551", "volume": "13", "issue": "5", "pages": "100124", "issn-l": "1939-4551"}, "abstract": "Spring and Summer 2020 are unique in that the challenges of care for those suffering from pollen allergy coincide with the COVID-19 pandemic. Several considerations are important to allow optimal care of allergic rhinitis (AR) and asthma and hence prevention of coronavirus spread through sneezing, rhinorrhoea, and coughing. This compact overview of recommendations by the EUFOREA expert teams on allergic airway diseases and allergen-specific immunotherapy (AIT) is based on investigation of the current COVID-19 literature in association with the key words above and shared clinical experience of the experts involved. It deals with similarities and differences between AR and coronavirus infection, specific recommendations for allergic disease care in the COVID-19 era, including guidance on AIT.", "doi": "10.1016/j.waojou.2020.100124", "pmid": "32426089", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1939-4551(20)30027-2"}, {"db": "pii", "key": "100124"}, {"db": "pmc", "key": "PMC7229977"}], "notes": [], "created": "2020-11-25T08:35:35.107Z", "modified": "2020-12-09T11:41:32.455Z"}, {"entity": "publication", "iuid": "311580f756de4896bcebd20ebf489053", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/311580f756de4896bcebd20ebf489053.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/311580f756de4896bcebd20ebf489053"}}, "title": "A global recommendation for restrictive provision of fertility treatments during the COVID-19 pandemic.", "authors": [{"family": "Rodriguez-Wallberg", "given": "Kenny A", "initials": "KA"}, {"family": "Wikander", "given": "Ida", "initials": "I"}], "type": "editorial", "published": "2020-05-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "5", "pages": "569-570", "issn-l": "0001-6349"}, "abstract": "Editorial", "doi": "10.1111/aogs.13851", "pmid": "32270485", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7262212"}], "notes": [], "created": "2020-11-22T17:11:24.352Z", "modified": "2020-12-09T12:02:52.026Z"}, {"entity": "publication", "iuid": "aa52c6883f014263ae471d5182574d50", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aa52c6883f014263ae471d5182574d50.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aa52c6883f014263ae471d5182574d50"}}, "title": "[Covid-19 - deaths and analysis].", "authors": [{"family": "Modig", "given": "Karin", "initials": "K"}, {"family": "Ahlbom", "given": "Anders", "initials": "A"}, {"family": "Matthews", "given": "Anthony", "initials": "A"}], "type": "journal article", "published": "2020-04-30", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "volume": "117", "issue": null, "issn-l": "0023-7205"}, "abstract": "Mortality from Covid-19 is monitored in detail and compared between countries with different strategies against the virus. There is, however, often a lack of understanding of what is required in terms of measures and interpretation to enable correct comparisons. The number of deaths from Covid-19 is affected by the testing strategy and many other things that differ between countries. Therefore, today, the most reliable source for monitoring and comparing mortality from Covid-19 is total mortality. In Sweden, there is good correspondence of Covid-19 deaths and total mortality, with a tendency to a higher total mortality indicating some under-reporting of Covid-19 mortality.", "doi": null, "pmid": "32365212", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "F3XL"}], "notes": [], "created": "2020-12-10T07:26:31.854Z", "modified": "2023-01-13T14:49:29.532Z"}, {"entity": "publication", "iuid": "39986cc3e1564ff185d21484709b3b5c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/39986cc3e1564ff185d21484709b3b5c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/39986cc3e1564ff185d21484709b3b5c"}}, "title": "Physical Activity During the Coronavirus (COVID-19) Pandemic: Prevention of a Decline in Metabolic and Immunological Functions", "authors": [{"family": "Jakobsson", "given": "Johan", "initials": "J"}, {"family": "Malm", "given": "Christer", "initials": "C"}, {"family": "Furberg", "given": "Maria", "initials": "M"}, {"family": "Ekelund", "given": "Ulf", "initials": "U"}, {"family": "Svensson", "given": "Michael", "initials": "M"}], "type": "journal-article", "published": "2020-04-30", "journal": {"title": "Front Sports Act Living", "issn": "2624-9367", "volume": "2", "issue": null, "pages": "57", "issn-l": null}, "abstract": null, "doi": "10.3389/fspor.2020.00057", "pmid": "33345048", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7739799"}], "notes": [], "created": "2021-01-07T13:31:10.740Z", "modified": "2021-12-06T12:58:44.937Z"}, {"entity": "publication", "iuid": "68ad55ebf84544769e6502910e61ca19", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68ad55ebf84544769e6502910e61ca19.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68ad55ebf84544769e6502910e61ca19"}}, "title": "[Bats and humans].", "authors": [{"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-04-29", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": "Coronavirus (CoV) species are very common among animals, especially bats. The last two decades three large CoV outbreaks have appeared among humans; Severe Adult Respiratory Syndrome (SARS-1) in 2003, Middle East Respiratory Syndrome (MERS) in 2012 and SARS-2 in 2019, (COVID19). Also a large epidemic among swine, Swine Acute Diarrhea Syndrome (SADS) appeared in 2017 in China. There is a pool of coronavirus among bats which have the potential to infect humans through the ACE2 receptor, and new human epidemics can be expected. Therefore it is of great importance to develop new antivirals and vaccines against CoV as well as to improve the global infectious disease control of these infections.", "doi": null, "pmid": "32365214", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "F3UA"}], "notes": [], "created": "2020-11-25T07:21:34.085Z", "modified": "2021-12-06T12:57:40.712Z"}, {"entity": "publication", "iuid": "ce2f2dd752d04c168bef529206081d55", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ce2f2dd752d04c168bef529206081d55.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ce2f2dd752d04c168bef529206081d55"}}, "title": "Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs.", "authors": [{"family": "Neogi", "given": "Ujjwal", "initials": "U"}, {"family": "Hill", "given": "Kyle J", "initials": "KJ"}, {"family": "Ambikan", "given": "Anoop T", "initials": "AT"}, {"family": "Heng", "given": "Xiao", "initials": "X"}, {"family": "Quinn", "given": "Thomas P", "initials": "TP"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Sarafianos", "given": "Stefan G", "initials": "SG"}, {"family": "Singh", "given": "Kamal", "initials": "K"}], "type": "journal article", "published": "2020-04-26", "journal": {"title": "Pathogens", "issn": "2076-0817", "issn-l": "2076-0817", "volume": "9", "issue": "5", "pages": null}, "abstract": "Coronaviruses (CoVs) are positive-stranded RNA viruses that infect humans and animals. Infection by CoVs such as HCoV-229E, -NL63, -OC43 and -HKU1 leads to the common cold, short lasting rhinitis, cough, sore throat and fever. However, CoVs such as Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and the newest SARS-CoV-2 (the causative agent of COVID-19) lead to severe and deadly diseases with mortality rates ranging between ~1 to 35% depending on factors such as age and pre-existing conditions. Despite continuous global health threats to humans, there are no approved vaccines or drugs targeting human CoVs, and the recent outbreak of COVID-19 emphasizes an urgent need for therapeutic interventions. Using computational and bioinformatics tools, here we present the feasibility of reported broad-spectrum RNA polymerase inhibitors as anti- SARS-CoV-2 drugs targeting its main RNA polymerase, suggesting that investigational and approved nucleoside RNA polymerase inhibitors have potential as anti-SARS-CoV-2 drugs. However, we note that it is also possible for SARS-CoV-2 to evolve and acquire drug resistance mutations against these nucleoside inhibitors.", "doi": "10.3390/pathogens9050320", "pmid": "32357471", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "pathogens9050320"}, {"db": "pmc", "key": "PMC7281371"}], "notes": [], "created": "2020-11-25T07:17:57.790Z", "modified": "2021-02-26T08:45:25.910Z"}, {"entity": "publication", "iuid": "3271a08268724743b19292818e1e1faa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3271a08268724743b19292818e1e1faa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3271a08268724743b19292818e1e1faa"}}, "title": "The unsynchronized changes of CT image and nucleic acid detection in COVID-19: reports the two cases from Gansu, China.", "authors": [{"family": "Gao", "given": "Jing", "initials": "J"}, {"family": "Liu", "given": "Jun-Qiang", "initials": "JQ"}, {"family": "Wen", "given": "Heng-Jun", "initials": "HJ"}, {"family": "Liu", "given": "Hua", "initials": "H"}, {"family": "Hu", "given": "Wei-Dong", "initials": "WD"}, {"family": "Han", "given": "Xia", "initials": "X"}, {"family": "Li", "given": "Chuan-Xing", "initials": "CX"}, {"family": "Wang", "given": "Xiao-Jun", "initials": "XJ"}], "type": "case reports", "published": "2020-04-22", "journal": {"title": "Respir Res", "issn": "1465-993X", "volume": "21", "issue": "1", "pages": "96", "issn-l": "1465-9921"}, "abstract": "The novel coronavirus disease (COVID-19) outbreak started in December 2019 in Wuhan, China, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The CT image is used to assess the disease progress, whereas the continued two times of negative results from SARS-CoV-2 nucleic acid detection had been considered as a criterion for ending antiviral treatment. We compared the two COVID-19 cases with similar backgrounds and CT image repeated intervals under treatment. Our report highlighted the unsynchronized expression in the changes of CT image and nucleic acid detection in COVID-19, and lasting positive nucleic acid test result in patients recovered from pneumonia. It may be contributed to recognize the disease and improve prevention.", "doi": "10.1186/s12931-020-01363-7", "pmid": "32321530", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Provided in the article: CT images for 2 patients over 12 days", "description": null}], "notes": [], "created": "2020-11-23T11:43:52.411Z", "modified": "2021-02-26T08:45:48.033Z"}, {"entity": "publication", "iuid": "0ec3865d29d940b4ae522d567b465ae1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ec3865d29d940b4ae522d567b465ae1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ec3865d29d940b4ae522d567b465ae1"}}, "title": "Systematic Review of Important Viral Diseases in Africa in Light of the \u2018One Health\u2019 Concept", "authors": [{"family": "Chauhan", "given": "Ravendra P", "initials": "RP", "orcid": "0000-0002-4674-8255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d72198d117f42e094daefc52e6d8dfd.json"}}, {"family": "Dessie", "given": "Zelalem G", "initials": "ZG", "orcid": "0000-0001-9056-6822", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aef29117960a411cbfa4718222c2f690.json"}}, {"family": "Noreddin", "given": "Ayman", "initials": "A", "orcid": "0000-0003-4899-1168", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6ff11be70974f57aedb0646be4e17c1.json"}}, {"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME", "orcid": "0000-0002-1056-4761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58d2f06f64154a2f9b5b22ffbb7518a3.json"}}], "type": "journal-article", "published": "2020-04-20", "journal": {"title": "Pathogens", "issn": "2076-0817", "volume": "9", "issue": "4", "pages": "301", "issn-l": "2076-0817"}, "abstract": "Emerging and re-emerging viral diseases are of great public health concern. The recent emergence of Severe Acute Respiratory Syndrome (SARS) related coronavirus (SARS-CoV-2) in December 2019 in China, which causes COVID-19 disease in humans, and its current spread to several countries, leading to the first pandemic in history to be caused by a coronavirus, highlights the significance of zoonotic viral diseases. Rift Valley fever, rabies, West Nile, chikungunya, dengue, yellow fever, Crimean-Congo hemorrhagic fever, Ebola, and influenza viruses among many other viruses have been reported from different African countries. The paucity of information, lack of knowledge, limited resources, and climate change, coupled with cultural traditions make the African continent a hotspot for vector-borne and zoonotic viral diseases, which may spread globally. Currently, there is no information available on the status of virus diseases in Africa. This systematic review highlights the available information about viral diseases, including zoonotic and vector-borne diseases, reported in Africa. The findings will help us understand the trend of emerging and re-emerging virus diseases within the African continent. The findings recommend active surveillance of viral diseases and strict implementation of One Health measures in Africa to improve human public health and reduce the possibility of potential pandemics due to zoonotic viruses.", "doi": "10.3390/pathogens9040301", "pmid": "32325980", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "pathogens9040301"}, {"db": "pmc", "key": "PMC7238228"}], "notes": [], "created": "2020-11-19T14:19:08.521Z", "modified": "2021-12-06T12:56:28.620Z"}, {"entity": "publication", "iuid": "e0e3251f02a949849818c8647d613c7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e0e3251f02a949849818c8647d613c7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e0e3251f02a949849818c8647d613c7a"}}, "title": "Essential care of critical illness must not be forgotten in the COVID-19 pandemic.", "authors": [{"family": "Baker", "given": "Tim", "initials": "T"}, {"family": "Schell", "given": "Carl Otto", "initials": "CO"}, {"family": "Petersen", "given": "Dan Brun", "initials": "DB"}, {"family": "Sawe", "given": "Hendry", "initials": "H"}, {"family": "Khalid", "given": "Karima", "initials": "K"}, {"family": "Mndolo", "given": "Samson", "initials": "S"}, {"family": "Rylance", "given": "Jamie", "initials": "J"}, {"family": "McAuley", "given": "Daniel F", "initials": "DF"}, {"family": "Roy", "given": "Nobhojit", "initials": "N"}, {"family": "Marshall", "given": "John", "initials": "J"}, {"family": "Wallis", "given": "Lee", "initials": "L"}, {"family": "Molyneux", "given": "Elizabeth", "initials": "E"}], "type": "letter", "published": "2020-04-18", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "395", "issue": "10232", "pages": "1253-1254", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)30793-5", "pmid": "32246914", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)30793-5"}, {"db": "pmc", "key": "PMC7270584"}], "notes": [], "created": "2020-11-19T14:16:58.470Z", "modified": "2020-12-09T11:48:50.291Z"}, {"entity": "publication", "iuid": "111c43323baa4cdf84eeecd9a2dc7af9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/111c43323baa4cdf84eeecd9a2dc7af9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/111c43323baa4cdf84eeecd9a2dc7af9"}}, "title": "Steroid-responsive encephalitis in Covid-19 disease", "authors": [{"family": "Pilotto", "given": "Andrea", "initials": "A", "orcid": "0000-0003-2029-6606", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/221835a6e81a4a4eb7e302df55681c23.json"}}, {"family": "Odolini", "given": "Silvia", "initials": "S"}, {"family": "Masciocchi S", "given": "Stefano", "initials": "S"}, {"family": "Comelli", "given": "Agnese", "initials": "A"}, {"family": "Volonghi", "given": "Irene", "initials": "I"}, {"family": "Gazzina", "given": "Stefano", "initials": "S"}, {"family": "Nocivelli", "given": "Sara", "initials": "S"}, {"family": "Pezzini", "given": "Alessandro", "initials": "A"}, {"family": "Foc\u00e0", "given": "Emanuele", "initials": "E"}, {"family": "Caruso", "given": "Arnaldo", "initials": "A"}, {"family": "Leonardi", "given": "Matilde", "initials": "M"}, {"family": "Pasolini", "given": "Maria Pia", "initials": "MP"}, {"family": "Gasparotti R", "given": "Roberto", "initials": "R"}, {"family": "Castelli F", "given": "Francesco", "initials": "F"}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Padovani", "given": "Alessandro", "initials": "A"}], "type": "posted-content", "published": "2020-04-17", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.04.12.20062646", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-06-17T07:56:31.458Z", "modified": "2022-11-22T05:52:11.424Z"}, {"entity": "publication", "iuid": "f3f7011473894c83b2e34fa2ea6980ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f3f7011473894c83b2e34fa2ea6980ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f3f7011473894c83b2e34fa2ea6980ae"}}, "title": "ACE2 and coronavirus - a question of balance and dynamics?", "authors": [{"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A"}, {"family": "Sand\u00e9n", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2020-04-17", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": "The new SARS-CoV-2 virus enters cells via angiotensin-converting enzyme 2 (ACE2). ACE2 counteracts ACE and angiotensin II in the renin-angiotensin-aldosterone system (RAAS) and has critical functions in the lung and cardiovascular system. SARS-CoV was found to down-regulate ACE2, leaving angiotensin II unbalanced in affected organs. A similar effect of SARS-CoV-2 could partly explain risk factors and symptoms, and could potentially be treatable.", "doi": null, "pmid": "32314329", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "F3S3"}], "notes": [], "created": "2020-11-23T11:42:16.237Z", "modified": "2020-12-08T07:17:55.750Z"}, {"entity": "publication", "iuid": "8ff1da243d924635a0a9dbf4d20e1dce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ff1da243d924635a0a9dbf4d20e1dce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ff1da243d924635a0a9dbf4d20e1dce"}}, "title": "COVID-19 and Working Conditions in Health Care.", "authors": [{"family": "Theorell", "given": "T\u00f6res", "initials": "T"}], "type": "editorial", "published": "2020-04-16", "journal": {"title": "Psychother Psychosom", "issn": "1423-0348", "volume": "89", "issue": "4", "pages": "193-194", "issn-l": "0033-3190"}, "abstract": "Editorial", "doi": "10.1159/000507765", "pmid": "32299083", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "000507765"}, {"db": "pmc", "key": "PMC7206352"}], "notes": [], "created": "2020-11-23T11:30:26.354Z", "modified": "2020-12-09T14:49:06.411Z"}, {"entity": "publication", "iuid": "f7a80019e75845f4968677a6d71180bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7a80019e75845f4968677a6d71180bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7a80019e75845f4968677a6d71180bf"}}, "title": "Intervention strategies against COVID-19 and their estimated impact on Swedish healthcare capacity", "authors": [{"family": "Gardner", "given": "Jasmine M", "initials": "JM", "orcid": "0000-0002-6399-8504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/142f79739167491c9024e0fb17187f2f.json"}}, {"family": "Willem", "given": "Lander", "initials": "L", "orcid": "0000-0002-9210-1196", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/485594f08c334c55bcf8b1159db1befc.json"}}, {"family": "Van Der Wijngaart", "given": "Wouter", "initials": "W", "orcid": "0000-0001-8248-6670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08189699080c43df85b527923d969525.json"}}, {"family": "Kamerlin", "given": "Shina Caroline Lynn", "initials": "SCL", "orcid": "0000-0002-3190-1173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce94c3055e2b4f50b0ff4c16eac65658.json"}}, {"family": "Brusselaers", "given": "Nele", "initials": "N", "orcid": "0000-0003-0137-447X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8a4e9c84a5843c18e95fe0becb19506.json"}}, {"family": "Kasson", "given": "Peter", "initials": "P", "orcid": "0000-0002-3111-8103", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa48f188557f4339bbe05fa87f336b37.json"}}], "type": "posted-content", "published": "2020-04-15", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.04.11.20062133", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-17T08:36:28.175Z", "modified": "2022-11-22T05:52:03.951Z"}, {"entity": "publication", "iuid": "09ace0cf9b2b48a8b3235cd5c546314b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/09ace0cf9b2b48a8b3235cd5c546314b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/09ace0cf9b2b48a8b3235cd5c546314b"}}, "title": "Editorial: Covid-19 and Physical and Rehabilitation Medicine.", "authors": [{"family": "Borg", "given": "Kristian", "initials": "K"}, {"family": "Stam", "given": "Henk", "initials": "H"}], "type": "editorial", "published": "2020-04-15", "journal": {"title": "J Rehabil Med", "issn": "1651-2081", "volume": "52", "issue": "4", "pages": "jrm00045", "issn-l": null}, "abstract": null, "doi": "10.2340/16501977-2679", "pmid": "32286673", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-09T12:06:38.361Z", "modified": "2020-12-09T12:06:38.383Z"}, {"entity": "publication", "iuid": "f5023749413543a6bf5155fed22df06c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f5023749413543a6bf5155fed22df06c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f5023749413543a6bf5155fed22df06c"}}, "title": "Pediatric Endocrinology in the Time of the COVID-19 Pandemic.", "authors": [{"family": "Cianfarani", "given": "Stefano", "initials": "S"}], "type": "editorial", "published": "2020-04-09", "journal": {"title": "Horm Res Paediatr", "issn": "1663-2826", "volume": "92", "issue": "6", "pages": "345-346", "issn-l": "1663-2818"}, "abstract": "Editorial", "doi": "10.1159/000507703", "pmid": "32272473", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "000507703"}, {"db": "pmc", "key": "PMC7206355"}], "notes": [], "created": "2020-11-23T11:36:15.264Z", "modified": "2020-12-09T12:04:34.240Z"}, {"entity": "publication", "iuid": "9b929466d23449f79a9fc7631737267f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b929466d23449f79a9fc7631737267f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b929466d23449f79a9fc7631737267f"}}, "title": "F\u00f6rlorat luktsinne \u2013 m\u00f6jligt tidigt tecken p\u00e5 covid-19", "authors": [{"family": "N Lundstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Stj\u00e4rne", "given": "P\u00e4r", "initials": "P"}], "type": "journal article", "published": "2020-04-08", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "volume": "117", "issue": null, "pages": null, "issn-l": "0023-7205"}, "abstract": "Comment", "doi": null, "pmid": "32293016", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "F3P9"}], "notes": [], "created": "2020-11-23T11:29:43.793Z", "modified": "2021-12-06T12:51:58.143Z"}, {"entity": "publication", "iuid": "56b0c4045cd34bcfa299c09a7806480b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56b0c4045cd34bcfa299c09a7806480b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56b0c4045cd34bcfa299c09a7806480b"}}, "title": "Only strict quarantine measures can curb the coronavirus disease (COVID-19) outbreak in Italy, 2020", "authors": [{"family": "Sj\u00f6din", "given": "Henrik", "initials": "H"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Osman", "given": "Sarah", "initials": "S"}, {"family": "Farooq", "given": "Zia", "initials": "Z"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}], "type": "journal-article", "published": "2020-04-02", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "13", "issn-l": null}, "abstract": "Several Italian towns are under lockdown to contain the COVID-19 outbreak. The level of transmission reduction required for physical distancing interventions to mitigate the epidemic is a crucial question. We show that very high adherence to community quarantine (total stay-home policy) and a small household size is necessary for curbing the outbreak in a locked-down town. The larger the household size and amount of time in the public, the longer the lockdown period needed.", "doi": "10.2807/1560-7917.es.2020.25.13.2000280", "pmid": "32265005", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7140595"}], "notes": [], "created": "2020-12-09T12:02:19.916Z", "modified": "2021-12-06T12:50:36.128Z"}, {"entity": "publication", "iuid": "843a79f658174ae8bd88e64050cf7fc9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/843a79f658174ae8bd88e64050cf7fc9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/843a79f658174ae8bd88e64050cf7fc9"}}, "title": "COVID-19: GENERAL GUIDELINES FOR CARDIOVASCULAR SURGEONS (standard guidelines - subject to change).", "authors": [{"family": "Barros", "given": "Leila", "initials": "L"}, {"family": "Rivetti", "given": "Luiz Ant\u00f4nio", "initials": "LA"}, {"family": "Furlanetto", "given": "Beatriz Helena", "initials": "BH"}, {"family": "Teixeira", "given": "Eduardo Miranda", "initials": "EM"}, {"family": "Welikow", "given": "Alexandre", "initials": "A"}], "type": "editorial", "published": "2020-04-01", "journal": {"title": "Braz J Cardiovasc Surg", "issn": "1678-9741", "volume": "35", "issue": "2", "pages": "I-III", "issn-l": null}, "abstract": null, "doi": "10.21470/1678-9741-1-2020-0604", "pmid": "32369287", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7199979"}], "notes": [], "created": "2020-12-10T07:29:07.890Z", "modified": "2020-12-10T07:29:07.913Z"}, {"entity": "publication", "iuid": "377dff7d7d5d47d1861a22cd559bfac5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/377dff7d7d5d47d1861a22cd559bfac5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/377dff7d7d5d47d1861a22cd559bfac5"}}, "title": "The Current Clinically Relevant Findings on COVID-19 Pandemic.", "authors": [{"family": "Pergolizzi", "given": "Joseph V", "initials": "JV"}, {"family": "Magnusson", "given": "Peter", "initials": "P"}, {"family": "LeQuang", "given": "Jo Ann", "initials": "JA"}, {"family": "Breve", "given": "Frank", "initials": "F"}, {"family": "Paladini", "given": "Antonella", "initials": "A"}, {"family": "Rekatsina", "given": "Martina", "initials": "M"}, {"family": "Yeam", "given": "Cheng Teng", "initials": "CT"}, {"family": "Imani", "given": "Farnad", "initials": "F"}, {"family": "Saltelli", "given": "Giorgia", "initials": "G"}, {"family": "Taylor", "given": "Robert", "initials": "R"}, {"family": "Wollmuth", "given": "Charles", "initials": "C"}, {"family": "Varrassi", "given": "Giustino", "initials": "G"}], "type": "journal article", "published": "2020-04-00", "journal": {"title": "Anesth Pain Med", "issn": "2228-7523", "volume": "10", "issue": "2", "pages": "e103819", "issn-l": null}, "abstract": "The emergence of a novel coronavirus and coronavirus disease 2019 (COVID-19) represents a challenge to global healthcare. In the past 20 years, this is the third coronavirus that jumped the species barrier and infected humans. It is highly contagious but associated with low pathogenicity. First identified in Wuhan, China, a city of over 11 million, the disease has since spread to every continent except Antarctica. About 15% to 20% of all cases may be called severe, and it is believed many cases are asymptomatic. The average age of a person with COVID has been reported as 49 years. Worse outcomes are associated with geriatric populations and those with underlying diseases such as cardiovascular, respiratory disorders, and/or diabetes. The coronavirus, like other coronaviruses, is highly contagious and has a latency period of about 14 days. Most patients present with fever and a dry cough, but fever may be absent. Differential diagnosis can be challenging since influenza may present with similar symptoms. Chest radiography or computed tomography may be used to find evidence of secondary pneumonia. Nosocomial infection is of concern, and it has been reported that 3.8% of all cases with COVID-19 in that country involve healthcare workers in China. Most patients have mild disease, and supportive care suffices. A variety of repurposed and investigational drugs are being evaluated. There are currently no antiviral therapies or vaccines, even if many therapies are proposed. Hand hygiene, social distancing, and scientifically sound information are the best strategies at the moment to combat this epidemic.", "doi": "10.5812/aapm.103819", "pmid": "32754437", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7352949"}], "notes": [], "created": "2020-11-26T12:19:57.995Z", "modified": "2020-11-30T08:42:57.911Z"}, {"entity": "publication", "iuid": "39912591ca454520996acbfbd8dba3e6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/39912591ca454520996acbfbd8dba3e6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/39912591ca454520996acbfbd8dba3e6"}}, "title": "The COVID-19 pandemic: The \u2018black swan\u2019 for mental health care and a turning point for e-health", "authors": [{"family": "Wind", "given": "Tim R", "initials": "TR"}, {"family": "Rijkeboer", "given": "Marleen", "initials": "M"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Riper", "given": "Heleen", "initials": "H"}], "type": "journal-article", "published": "2020-04-00", "journal": {"title": "Internet Interv", "issn": "2214-7829", "volume": "20", "issue": null, "pages": "100317", "issn-l": "2214-7829"}, "abstract": "Editorial", "doi": "10.1016/j.invent.2020.100317", "pmid": "32289019", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2214-7829(20)30046-4"}, {"db": "pii", "key": "100317"}, {"db": "pmc", "key": "PMC7104190"}], "notes": [], "created": "2020-11-25T07:15:05.334Z", "modified": "2021-12-06T12:50:54.330Z"}, {"entity": "publication", "iuid": "a285403dbfaf42e893ce70fc3cd5bbde", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a285403dbfaf42e893ce70fc3cd5bbde.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a285403dbfaf42e893ce70fc3cd5bbde"}}, "title": "Novel corona virus disease (COVID\u201019) in pregnancy: What clinical recommendations to follow?", "authors": [{"family": "Liang", "given": "Huan", "initials": "H"}, {"family": "Acharya", "given": "Ganesh", "initials": "G", "orcid": "0000-0002-1997-3107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d1c2ac0dfb849d8b2374451e38cdcba.json"}}], "type": "journal-article", "published": "2020-04-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "0001-6349", "volume": "99", "issue": "4", "pages": "439-442", "issn-l": null}, "abstract": "Editorial", "doi": "10.1111/aogs.13836", "pmid": "32141062", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-22T16:58:43.722Z", "modified": "2021-12-06T12:50:02.730Z"}, {"entity": "publication", "iuid": "8760bdfa78534e329ab14882337e1681", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8760bdfa78534e329ab14882337e1681.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8760bdfa78534e329ab14882337e1681"}}, "title": "Harnessing the immune system via Fc\u03b3R function in immune therapy: a pathway to next\u2010gen mAbs", "authors": [{"family": "Chenoweth", "given": "Alicia M", "initials": "AM"}, {"family": "Wines", "given": "Bruce D", "initials": "BD"}, {"family": "Anania", "given": "Jessica C", "initials": "JC"}, {"family": "Mark Hogarth", "given": "P", "initials": "P"}], "type": "journal-article", "published": "2020-04-00", "journal": {"title": "Immunol Cell Biol", "issn": "0818-9641", "volume": "98", "issue": "4", "pages": "287-304", "issn-l": null}, "abstract": "The human fragment crystallizable (Fc)\u03b3 receptor (R) interacts with antigen-complexed immunoglobulin (Ig)G ligands to both activate and modulate a powerful network of inflammatory host-protective effector functions that are key to the normal physiology of immune resistance to pathogens. More than 100 therapeutic monoclonal antibodies (mAbs) are approved or in late stage clinical trials, many of which harness the potent Fc\u03b3R-mediated effector systems to varying degrees. This is most evident for antibodies targeting cancer cells inducing antibody-dependent killing or phagocytosis but is also true to some degree for the mAbs that neutralize or remove small macromolecules such as cytokines or other Igs. The use of mAb therapeutics has also revealed a \"scaffolding\" role for Fc\u03b3R which, in different contexts, may either underpin the therapeutic mAb action such as immune agonism or trigger catastrophic adverse effects. The still unmet therapeutic need in many cancers, inflammatory diseases or emerging infections such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires increased effort on the development of improved and novel mAbs. A more mature appreciation of the immunobiology of individual Fc\u03b3R function and the complexity of the relationships between Fc\u03b3Rs and antibodies is fueling efforts to develop more potent \"next-gen\" therapeutic antibodies. Such development strategies now include focused glycan or protein engineering of the Fc to increase affinity and/or tailor specificity for selective engagement of individual activating Fc\u03b3Rs or the inhibitory Fc\u03b3RIIb or alternatively, for the ablation of Fc\u03b3R interaction altogether. This review touches on recent aspects of Fc\u03b3R and IgG immunobiology and its relationship with the present and future actions of therapeutic mAbs.", "doi": "10.1111/imcb.12326", "pmid": "32157732", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7228307"}], "notes": [], "created": "2020-11-22T09:23:12.446Z", "modified": "2021-12-06T12:49:37.522Z"}, {"entity": "publication", "iuid": "0468f23a15f441f5b13ce8e44305625a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0468f23a15f441f5b13ce8e44305625a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0468f23a15f441f5b13ce8e44305625a"}}, "title": "A hundred days into the coronavirus disease (COVID-19) pandemic.", "authors": [{"family": "Steffens", "given": "Ines", "initials": "I"}], "type": "editorial", "published": "2020-04-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "14", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.14.2000550", "pmid": "32290905", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7160442"}], "notes": [], "created": "2020-12-09T12:07:21.950Z", "modified": "2021-12-06T12:49:10.360Z"}, {"entity": "publication", "iuid": "924a0d531a614d58a8ed52f344fb1932", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/924a0d531a614d58a8ed52f344fb1932.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/924a0d531a614d58a8ed52f344fb1932"}}, "title": "Novel Coronavirus Infection (COVID-19) in Humans: A Scoping Review and Meta-Analysis.", "authors": [{"family": "Borges do Nascimento", "given": "Israel J\u00fanior", "initials": "IJ"}, {"family": "Cacic", "given": "Nensi", "initials": "N"}, {"family": "Abdulazeem", "given": "Hebatullah Mohamed", "initials": "HM"}, {"family": "von Groote", "given": "Thilo Caspar", "initials": "TC"}, {"family": "Jayarajah", "given": "Umesh", "initials": "U"}, {"family": "Weerasekara", "given": "Ishanka", "initials": "I"}, {"family": "Esfahani", "given": "Meisam Abdar", "initials": "MA"}, {"family": "Civile", "given": "Vinicius Tassoni", "initials": "VT"}, {"family": "Marusic", "given": "Ana", "initials": "A"}, {"family": "Jeroncic", "given": "Ana", "initials": "A"}, {"family": "Carvas Junior", "given": "Nelson", "initials": "N"}, {"family": "Pericic", "given": "Tina Poklepovic", "initials": "TP"}, {"family": "Zakarija-Grkovic", "given": "Irena", "initials": "I"}, {"family": "Meirelles Guimar\u00e3es", "given": "Silvana Mangeon", "initials": "SM"}, {"family": "Luigi Bragazzi", "given": "Nicola", "initials": "N"}, {"family": "Bjorklund", "given": "Maria", "initials": "M"}, {"family": "Sofi-Mahmudi", "given": "Ahmad", "initials": "A"}, {"family": "Altujjar", "given": "Mohammad", "initials": "M"}, {"family": "Tian", "given": "Maoyi", "initials": "M"}, {"family": "Arcani", "given": "Diana Maria Cespedes", "initials": "DMC"}, {"family": "O'Math\u00fana", "given": "D\u00f3nal P", "initials": "DP"}, {"family": "Marcolino", "given": "Milena Soriano", "initials": "MS"}], "type": "journal article", "published": "2020-03-30", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "9", "issue": "4", "issn-l": "2077-0383"}, "abstract": "A growing body of literature on the 2019 novel coronavirus (SARS-CoV-2) is becoming available, but a synthesis of available data has not been conducted. We performed a scoping review of currently available clinical, epidemiological, laboratory, and chest imaging data related to the SARS-CoV-2 infection. We searched MEDLINE, Cochrane CENTRAL, EMBASE, Scopus and LILACS from 01 January 2019 to 24 February 2020. Study selection, data extraction and risk of bias assessment were performed by two independent reviewers. Qualitative synthesis and meta-analysis were conducted using the clinical and laboratory data, and random-effects models were applied to estimate pooled results. A total of 61 studies were included (59,254 patients). The most common disease-related symptoms were fever (82%, 95% confidence interval (CI) 56%-99%; n = 4410), cough (61%, 95% CI 39%-81%; n = 3985), muscle aches and/or fatigue (36%, 95% CI 18%-55%; n = 3778), dyspnea (26%, 95% CI 12%-41%; n = 3700), headache in 12% (95% CI 4%-23%, n = 3598 patients), sore throat in 10% (95% CI 5%-17%, n = 1387) and gastrointestinal symptoms in 9% (95% CI 3%-17%, n = 1744). Laboratory findings were described in a lower number of patients and revealed lymphopenia (0.93 \u00d7 109/L, 95% CI 0.83-1.03 \u00d7 109/L, n = 464) and abnormal C-reactive protein (33.72 mg/dL, 95% CI 21.54-45.91 mg/dL; n = 1637). Radiological findings varied, but mostly described ground-glass opacities and consolidation. Data on treatment options were limited. All-cause mortality was 0.3% (95% CI 0.0%-1.0%; n = 53,631). Epidemiological studies showed that mortality was higher in males and elderly patients. The majority of reported clinical symptoms and laboratory findings related to SARS-CoV-2 infection are non-specific. Clinical suspicion, accompanied by a relevant epidemiological history, should be followed by early imaging and virological assay.", "doi": "10.3390/jcm9040941", "pmid": "32235486", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jcm9040941"}, {"db": "pmc", "key": "PMC7230636"}], "notes": [], "created": "2020-11-30T16:01:46.945Z", "modified": "2020-12-09T11:48:12.765Z"}, {"entity": "publication", "iuid": "b9110c7439e54c1a983a6e0fbc7748c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9110c7439e54c1a983a6e0fbc7748c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9110c7439e54c1a983a6e0fbc7748c9"}}, "title": "COVID-19: towards controlling of a pandemic.", "authors": [{"family": "Bedford", "given": "Juliet", "initials": "J"}, {"family": "Enria", "given": "Delia", "initials": "D"}, {"family": "Giesecke", "given": "Johan", "initials": "J"}, {"family": "Heymann", "given": "David L", "initials": "DL"}, {"family": "Ihekweazu", "given": "Chikwe", "initials": "C"}, {"family": "Kobinger", "given": "Gary", "initials": "G"}, {"family": "Lane", "given": "H Clifford", "initials": "HC"}, {"family": "Memish", "given": "Ziad", "initials": "Z"}, {"family": "Oh", "given": "Myoung-Don", "initials": "MD"}, {"family": "Sall", "given": "Amadou Alpha", "initials": "AA"}, {"family": "Schuchat", "given": "Anne", "initials": "A"}, {"family": "Ungchusak", "given": "Kumnuan", "initials": "K"}, {"family": "Wieler", "given": "Lothar H", "initials": "LH"}, {"family": "WHO Strategic and Technical Advisory Group for Infectious Hazards", "given": "", "initials": ""}], "type": "journal article", "published": "2020-03-28", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "395", "issue": "10229", "pages": "1015-1018", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)30673-5", "pmid": "32197103", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)30673-5"}, {"db": "pmc", "key": "PMC7270596"}], "notes": [], "created": "2020-11-22T17:02:19.626Z", "modified": "2020-12-10T09:04:01.272Z"}, {"entity": "publication", "iuid": "551696f1ed29428c891af663c479317e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/551696f1ed29428c891af663c479317e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/551696f1ed29428c891af663c479317e"}}, "title": "The Fear of COVID-19 Scale: Development and Initial Validation.", "authors": [{"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Imani", "given": "Vida", "initials": "V"}, {"family": "Saffari", "given": "Mohsen", "initials": "M"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "case reports", "published": "2020-03-27", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "issn-l": null, "volume": null, "issue": null, "pages": "1-9"}, "abstract": "The emergence of the COVID-19 and its consequences has led to fears, worries, and anxiety among individuals worldwide. The present study developed the Fear of COVID-19 Scale (FCV-19S) to complement the clinical efforts in preventing the spread and treating of COVID-19 cases.\r\n\r\nThe sample comprised 717 Iranian participants. The items of the FCV-19S were constructed based on extensive review of existing scales on fears, expert evaluations, and participant interviews. Several psychometric tests were conducted to ascertain its reliability and validity properties.\r\n\r\nAfter panel review and corrected item-total correlation testing, seven items with acceptable corrected item-total correlation (0.47 to 0.56) were retained and further confirmed by significant and strong factor loadings (0.66 to 0.74). Also, other properties evaluated using both classical test theory and Rasch model were satisfactory on the seven-item scale. More specifically, reliability values such as internal consistency ( \u03b1 = .82) and test-retest reliability (ICC = .72) were acceptable. Concurrent validity was supported by the Hospital Anxiety and Depression Scale (with depression, r = 0.425 and anxiety, r = 0.511) and the Perceived Vulnerability to Disease Scale (with perceived infectability, r = 0.483 and germ aversion, r = 0.459).\r\n\r\nThe Fear of COVID-19 Scale, a seven-item scale, has robust psychometric properties. It is reliable and valid in assessing fear of COVID-19 among the general population and will also be useful in allaying COVID-19 fears among individuals.", "doi": "10.1007/s11469-020-00270-8", "pmid": "32226353", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "270"}, {"db": "pmc", "key": "PMC7100496"}], "notes": [], "created": "2020-11-30T16:01:48.181Z", "modified": "2022-11-10T07:58:14.325Z"}, {"entity": "publication", "iuid": "c6ab29c6e3564897a13b3610d928cca6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c6ab29c6e3564897a13b3610d928cca6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c6ab29c6e3564897a13b3610d928cca6"}}, "title": "Combating COVID-19-The role of robotics in managing public health and infectious diseases.", "authors": [{"family": "Yang", "given": "Guang-Zhong", "initials": "GZ"}, {"family": "J Nelson", "given": "Bradley", "initials": "B"}, {"family": "Murphy", "given": "Robin R", "initials": "RR"}, {"family": "Choset", "given": "Howie", "initials": "H"}, {"family": "Christensen", "given": "Henrik", "initials": "H"}, {"family": "H Collins", "given": "Steven", "initials": "S"}, {"family": "Dario", "given": "Paolo", "initials": "P"}, {"family": "Goldberg", "given": "Ken", "initials": "K"}, {"family": "Ikuta", "given": "Koji", "initials": "K"}, {"family": "Jacobstein", "given": "Neil", "initials": "N"}, {"family": "Kragic", "given": "Danica", "initials": "D"}, {"family": "Taylor", "given": "Russell H", "initials": "RH"}, {"family": "McNutt", "given": "Marcia", "initials": "M"}], "type": "editorial", "published": "2020-03-25", "journal": {"title": "Sci Robot", "issn": "2470-9476", "volume": "5", "issue": "40", "issn-l": null}, "abstract": "COVID-19 may drive sustained research in robotics to address risks of infectious diseases.", "doi": "10.1126/scirobotics.abb5589", "pmid": "33022599", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "5/40/eabb5589"}], "notes": [], "created": "2020-12-01T18:16:32.224Z", "modified": "2020-12-01T18:16:32.248Z"}, {"entity": "publication", "iuid": "4dbadc63c07b41d4b20a9a1492bba241", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4dbadc63c07b41d4b20a9a1492bba241.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4dbadc63c07b41d4b20a9a1492bba241"}}, "title": "Hypertension and Diabetes Delay the Viral Clearance in COVID-19 Patients", "authors": [{"family": "Chen", "given": "Xiaoping", "initials": "X"}, {"family": "Hu", "given": "Wenjia", "initials": "W"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Mo", "given": "Pingzheng", "initials": "P"}, {"family": "Zhang", "given": "Yongxi", "initials": "Y"}, {"family": "Jiang", "given": "Qunqun", "initials": "Q"}, {"family": "Ma", "given": "Zhiyong", "initials": "Z"}, {"family": "Cao", "given": "Qian", "initials": "Q"}, {"family": "Deng", "given": "Liping", "initials": "L"}, {"family": "Song", "given": "Shihui", "initials": "S"}, {"family": "Zheng", "given": "Ruiying", "initials": "R"}, {"family": "Gao", "given": "Shicheng", "initials": "S"}, {"family": "Ke", "given": "Hengning", "initials": "H"}, {"family": "Gui", "given": "Xien", "initials": "X"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Li", "given": "Jinlin", "initials": "J"}, {"family": "Lindahl", "given": "Johanna F", "initials": "JF"}, {"family": "Xiong", "given": "Yong", "initials": "Y"}], "type": "posted-content", "published": "2020-03-24", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.03.22.20040774", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-17T08:39:04.505Z", "modified": "2023-06-19T15:38:10.655Z"}, {"entity": "publication", "iuid": "5156c5f3e35b41e8b789fbc7915c044c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5156c5f3e35b41e8b789fbc7915c044c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5156c5f3e35b41e8b789fbc7915c044c"}}, "title": "Covid-19 \u2013 uppdatering om klinisk bild och behandling", "authors": [{"family": "Glans", "given": "Hedvig", "initials": "H"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Aleman", "given": "Soo", "initials": "S"}], "type": "journal article", "published": "2020-03-23", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": null, "doi": null, "pmid": "32266709", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "F3HW"}], "notes": [], "created": "2020-11-22T17:09:54.906Z", "modified": "2021-02-26T08:45:48.147Z"}, {"entity": "publication", "iuid": "82ccc1b68ddb4510ae5faf4cd89ac89e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82ccc1b68ddb4510ae5faf4cd89ac89e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82ccc1b68ddb4510ae5faf4cd89ac89e"}}, "title": "COVID-19 healthcare demand and mortality in Sweden in response to non-pharmaceutical (NPIs) mitigation and suppression scenarios", "authors": [{"family": "Sj\u00f6din", "given": "Henrik", "initials": "H"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}, {"family": "Br\u00e4nnstr\u00f6m", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Farooq", "given": "Zia", "initials": "Z"}, {"family": "Kriit", "given": "Hedi Katre", "initials": "HK"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "\u00c5str\u00f6m", "given": "Christofer", "initials": "C"}, {"family": "Thunberg", "given": "Johan", "initials": "J"}, {"family": "S\u00f6derquist", "given": "M\u00e5rten", "initials": "M"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}], "type": "posted-content", "published": "2020-03-23", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.03.20.20039594", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-14T06:39:24.677Z", "modified": "2022-11-22T05:51:45.396Z"}, {"entity": "publication", "iuid": "130e2061ba1041cc976a4b994ce63471", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/130e2061ba1041cc976a4b994ce63471.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/130e2061ba1041cc976a4b994ce63471"}}, "title": "The reproductive number of COVID-19 is higher compared to SARS coronavirus.", "authors": [{"family": "Liu", "given": "Ying", "initials": "Y"}, {"family": "Gayle", "given": "Albert A", "initials": "AA"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}], "type": "journal article", "published": "2020-03-13", "journal": {"title": "J Travel Med", "issn": "1708-8305", "issn-l": null, "volume": "27", "issue": "2", "pages": null}, "abstract": null, "doi": "10.1093/jtm/taaa021", "pmid": "32052846", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5735319"}, {"db": "pmc", "key": "PMC7074654"}], "notes": [], "created": "2020-11-30T16:01:53.074Z", "modified": "2020-12-11T14:18:52.131Z"}, {"entity": "publication", "iuid": "2e73a2c38f314f2ca50f2e333abb227c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e73a2c38f314f2ca50f2e333abb227c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e73a2c38f314f2ca50f2e333abb227c"}}, "title": "Potential impact of seasonal forcing on a SARS-CoV-2 pandemic.", "authors": [{"family": "Neher", "given": "Richard A", "initials": "RA"}, {"family": "Dyrdak", "given": "Robert", "initials": "R", "orcid": "0000-0001-8456-4898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98ad76a0e144478cb3ceabd05c9928b0.json"}}, {"family": "Druelle", "given": "Valentin", "initials": "V"}, {"family": "Hodcroft", "given": "Emma B", "initials": "EB"}, {"family": "Albert", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2020-03-09", "journal": {"title": "Swiss Med Wkly", "issn": "1424-3997", "issn-l": "0036-7672", "volume": "150", "issue": null, "pages": "w20224"}, "abstract": "A novel coronavirus (SARS-CoV-2) first detected in Wuhan, China, has spread rapidly since December 2019, causing more than 100,000 confirmed infections and 4000 fatalities (as of 10 March 2020). The outbreak has been declared a pandemic by the WHO on Mar 11, 2020. Here, we explore how seasonal variation in transmissibility could modulate a SARS-CoV-2 pandemic. Data from routine diagnostics show a strong and consistent seasonal variation of the four endemic coronaviruses (229E, HKU1, NL63, OC43) and we parameterise our model for SARS-CoV-2 using these data. The model allows for many subpopulations of different size with variable parameters. Simulations of different scenarios show that plausible parameters result in a small peak in early 2020 in temperate regions of the Northern Hemisphere and a larger peak in winter 2020/2021. Variation in transmission and migration rates can result in substantial variation in prevalence between regions. While the uncertainty in parameters is large, the scenarios we explore show that transient reductions in the incidence rate might be due to a combination of seasonal variation and infection control efforts but do not necessarily mean the epidemic is contained. Seasonal forcing on SARS-CoV-2 should thus be taken into account in the further monitoring of the global transmission. The likely aggregated effect of seasonal variation, infection control measures, and transmission rate variation is a prolonged pandemic wave with lower prevalence at any given time, thereby providing a window of opportunity for better preparation of health care systems.", "doi": "10.4414/smw.2020.20224", "pmid": "32176808", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "Swiss Med Wkly. 2020;150:w20224"}], "notes": [], "created": "2020-11-17T17:38:57.263Z", "modified": "2023-06-19T14:45:01.419Z"}, {"entity": "publication", "iuid": "f4cd5fc5b81b412089e6ad0921ece7a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f4cd5fc5b81b412089e6ad0921ece7a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f4cd5fc5b81b412089e6ad0921ece7a0"}}, "title": "Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses.", "authors": [{"family": "Raoult", "given": "Didier", "initials": "D"}, {"family": "Zumla", "given": "Alimuddin", "initials": "A"}, {"family": "Locatelli", "given": "Franco", "initials": "F"}, {"family": "Ippolito", "given": "Giuseppe", "initials": "G"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}], "type": "editorial", "published": "2020-03-02", "journal": {"title": "Cell Stress", "issn": "2523-0204", "volume": "4", "issue": "4", "pages": "66-75", "issn-l": "2523-0204"}, "abstract": "Coronaviruses (CoVs) are a large family of enveloped, positive-strand RNA viruses. Four human CoVs (HCoVs), the non-severe acute respiratory syndrome (SARS)-like HCoVs (namely HCoV 229E, NL63, OC43, and HKU1), are globally endemic and account for a substantial fraction of upper respiratory tract infections. Non-SARS-like CoV can occasionally produce severe diseases in frail subjects but do not cause any major (fatal) epidemics. In contrast, SARS like CoVs (namely SARS-CoV and Middle-East respiratory syndrome coronavirus, MERS-CoV) can cause intense short-lived fatal outbreaks. The current epidemic caused by the highly contagious SARS-CoV-2 and its rapid spread globally is of major concern. There is scanty knowledge on the actual pandemic potential of this new SARS-like virus. It might be speculated that SARS-CoV-2 epidemic is grossly underdiagnosed and that the infection is silently spreading across the globe with two consequences: (i) clusters of severe infections among frail subjects could haphazardly occur linked to unrecognized index cases; (ii) the current epidemic could naturally fall into a low-level endemic phase when a significant number of subjects will have developed immunity. Understanding the role of paucisymptomatic subjects and stratifying patients according to the risk of developing severe clinical presentations is pivotal for implementing reasonable measures to contain the infection and to reduce its mortality. Whilst the future evolution of this epidemic remains unpredictable, classic public health strategies must follow rational patterns. The emergence of yet another global epidemic underscores the permanent challenges that infectious diseases pose and underscores the need for global cooperation and preparedness, even during inter-epidemic periods.", "doi": "10.15698/cst2020.04.216", "pmid": "32292881", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "CST0270E115"}, {"db": "pmc", "key": "PMC7064018"}], "notes": [], "created": "2020-11-23T11:27:23.267Z", "modified": "2020-12-09T12:09:26.162Z"}, {"entity": "publication", "iuid": "6067731d14094c8ca594582c6a13d5ab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6067731d14094c8ca594582c6a13d5ab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6067731d14094c8ca594582c6a13d5ab"}}, "title": "Updated rapid risk assessment from ECDC on the outbreak of COVID-19: increased transmission globally.", "authors": [], "type": "journal article", "published": "2020-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "9", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.9.2003051", "pmid": "32156331", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7068166"}], "notes": [], "created": "2020-12-08T06:53:18.558Z", "modified": "2020-12-10T09:04:59.875Z"}, {"entity": "publication", "iuid": "6e5b06134a9e41f4a197a3dba1698631", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e5b06134a9e41f4a197a3dba1698631.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e5b06134a9e41f4a197a3dba1698631"}}, "title": "Updated rapid risk assessment from ECDC on the novel coronavirus disease 2019 (COVID-19) pandemic: increased transmission in the EU/EEA and the UK.", "authors": [{"family": "Eurosurveillance editorial team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "25", "issue": "10", "pages": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.10.2003121", "pmid": "32183937", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7078827"}], "notes": [], "created": "2020-12-08T06:55:01.572Z", "modified": "2020-12-10T09:04:15.038Z"}, {"entity": "publication", "iuid": "555a9a24a05249b9b88c00e2e32d0ac4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/555a9a24a05249b9b88c00e2e32d0ac4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/555a9a24a05249b9b88c00e2e32d0ac4"}}, "title": "Rapidly increasing cumulative incidence of coronavirus disease (COVID-19) in the European Union/European Economic Area and the United Kingdom, 1 January to 15 March 2020.", "authors": [{"family": "Kinross", "given": "Pete", "initials": "P"}, {"family": "Suetens", "given": "Carl", "initials": "C"}, {"family": "Gomes Dias", "given": "Joana", "initials": "J"}, {"family": "Alexakis", "given": "Leonidas", "initials": "L"}, {"family": "Wijermans", "given": "Ariana", "initials": "A"}, {"family": "Colzani", "given": "Edoardo", "initials": "E"}, {"family": "Monnet", "given": "Dominique L", "initials": "DL"}, {"family": "ECDC Public Health Emergency Team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "25", "issue": "11", "pages": null}, "abstract": "The cumulative incidence of coronavirus disease (COVID-19) cases is showing similar trends in European Union/European Economic Area countries and the United Kingdom confirming that, while at a different stage depending on the country, the COVID-19 pandemic is progressing rapidly in all countries. Based on the experience from Italy, countries, hospitals and intensive care units should increase their preparedness for a surge of patients with COVID-19 who will require healthcare, and in particular intensive care.", "doi": "10.2807/1560-7917.ES.2020.25.11.2000285", "pmid": "32186277", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7096777"}], "notes": [], "created": "2020-12-08T06:56:51.256Z", "modified": "2021-02-26T08:45:48.168Z"}, {"entity": "publication", "iuid": "eea6eb2eee9947eead710b14e91c253a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eea6eb2eee9947eead710b14e91c253a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eea6eb2eee9947eead710b14e91c253a"}}, "title": "Potential scenarios for the progression of a COVID-19 epidemic in the European Union and the European Economic Area, March 2020.", "authors": [{"family": "Johnson", "given": "Helen C", "initials": "HC"}, {"family": "Gossner", "given": "C\u00e9line M", "initials": "CM"}, {"family": "Colzani", "given": "Edoardo", "initials": "E"}, {"family": "Kinsman", "given": "John", "initials": "J"}, {"family": "Alexakis", "given": "Leonidas", "initials": "L"}, {"family": "Beaut\u00e9", "given": "Julien", "initials": "J"}, {"family": "W\u00fcrz", "given": "Andrea", "initials": "A"}, {"family": "Tsolova", "given": "Svetla", "initials": "S"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Ekdahl", "given": "Karl", "initials": "K"}], "type": "journal article", "published": "2020-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "9", "issn-l": null}, "abstract": "Two months after the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the possibility of established and widespread community transmission in the European Union and European Economic Area (EU/EEA) is becoming more likely. We provide scenarios for use in preparedness for a possible widespread epidemic. The EU/EEA is moving towards the 'limited sustained transmission' phase. We propose actions to prepare for potential mitigation phases and coordinate efforts to protect the health of citizens.", "doi": "10.2807/1560-7917.ES.2020.25.9.2000202", "pmid": "32156332", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7068161"}], "notes": [], "created": "2020-12-08T06:54:09.547Z", "modified": "2020-12-10T09:04:40.162Z"}, {"entity": "publication", "iuid": "9dc9d035aaaf46ebba4567bc2ce6c865", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9dc9d035aaaf46ebba4567bc2ce6c865.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9dc9d035aaaf46ebba4567bc2ce6c865"}}, "title": "First cases of coronavirus disease 2019 (COVID-19) in the WHO European Region, 24 January to 21 February 2020.", "authors": [{"family": "Spiteri", "given": "Gianfranco", "initials": "G"}, {"family": "Fielding", "given": "James", "initials": "J"}, {"family": "Diercke", "given": "Michaela", "initials": "M"}, {"family": "Campese", "given": "Christine", "initials": "C"}, {"family": "Enouf", "given": "Vincent", "initials": "V"}, {"family": "Gaymard", "given": "Alexandre", "initials": "A"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Sognamiglio", "given": "Paola", "initials": "P"}, {"family": "Sierra Moros", "given": "Maria Jos\u00e9", "initials": "MJ"}, {"family": "Riutort", "given": "Antonio Nicolau", "initials": "AN"}, {"family": "Demina", "given": "Yulia V", "initials": "YV"}, {"family": "Mahieu", "given": "Romain", "initials": "R"}, {"family": "Broas", "given": "Markku", "initials": "M"}, {"family": "Bengn\u00e9r", "given": "Malin", "initials": "M"}, {"family": "Buda", "given": "Silke", "initials": "S"}, {"family": "Schilling", "given": "Julia", "initials": "J"}, {"family": "Filleul", "given": "Laurent", "initials": "L"}, {"family": "Lepoutre", "given": "Agn\u00e8s", "initials": "A"}, {"family": "Saura", "given": "Christine", "initials": "C"}, {"family": "Mailles", "given": "Alexandra", "initials": "A"}, {"family": "Levy-Bruhl", "given": "Daniel", "initials": "D"}, {"family": "Coignard", "given": "Bruno", "initials": "B"}, {"family": "Bernard-Stoecklin", "given": "Sibylle", "initials": "S"}, {"family": "Behillil", "given": "Sylvie", "initials": "S"}, {"family": "van der Werf", "given": "Sylvie", "initials": "S"}, {"family": "Valette", "given": "Martine", "initials": "M"}, {"family": "Lina", "given": "Bruno", "initials": "B"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Nicastri", "given": "Emanuele", "initials": "E"}, {"family": "Casas", "given": "Inmaculada", "initials": "I"}, {"family": "Larrauri", "given": "Amparo", "initials": "A"}, {"family": "Salom Castell", "given": "Magdalena", "initials": "M"}, {"family": "Pozo", "given": "Francisco", "initials": "F"}, {"family": "Maksyutov", "given": "Rinat A", "initials": "RA"}, {"family": "Martin", "given": "Charlotte", "initials": "C"}, {"family": "Van Ranst", "given": "Marc", "initials": "M"}, {"family": "Bossuyt", "given": "Nathalie", "initials": "N"}, {"family": "Siira", "given": "Lotta", "initials": "L"}, {"family": "Sane", "given": "Jussi", "initials": "J"}, {"family": "Tegmark-Wisell", "given": "Karin", "initials": "K"}, {"family": "Palm\u00e9rus", "given": "Maria", "initials": "M"}, {"family": "Broberg", "given": "Eeva K", "initials": "EK"}, {"family": "Beaut\u00e9", "given": "Julien", "initials": "J"}, {"family": "Jorgensen", "given": "Pernille", "initials": "P"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Pereyaslov", "given": "Dmitriy", "initials": "D"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Pukkila", "given": "Jukka", "initials": "J"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "Olsen", "given": "Sonja", "initials": "S"}, {"family": "Ciancio", "given": "Bruno Christian", "initials": "BC"}], "type": "journal article", "published": "2020-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "9", "issn-l": null}, "abstract": "In the WHO European Region, COVID-19 surveillance was implemented 27 January 2020. We detail the first European cases. As at 21 February, nine European countries reported 47 cases. Among 38 cases studied, 21 were linked to two clusters in Germany and France, 14 were infected in China. Median case age was 42 years; 25 were male. Late detection of the clusters' index cases delayed isolation of further local cases. As at 5 March, there were 4,250 cases.", "doi": "10.2807/1560-7917.ES.2020.25.9.2000178", "pmid": "32156327", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7068164"}], "notes": [], "created": "2020-12-08T06:52:02.863Z", "modified": "2020-12-10T09:05:36.064Z"}, {"entity": "publication", "iuid": "7a56f791eb7449fda11f805ef6c6f22e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a56f791eb7449fda11f805ef6c6f22e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a56f791eb7449fda11f805ef6c6f22e"}}, "title": "Note from the editors: World Health Organization declares novel coronavirus (2019-nCoV) sixth public health emergency of international concern.", "authors": [], "type": "journal article", "published": "2020-02-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "5", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.5.200131e", "pmid": "32019636", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7014669"}], "notes": [], "created": "2020-12-08T06:50:47.542Z", "modified": "2020-12-10T09:07:14.293Z"}, {"entity": "publication", "iuid": "3f28068739f0480fb93dab85b6750c3c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f28068739f0480fb93dab85b6750c3c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f28068739f0480fb93dab85b6750c3c"}}, "title": "Latest updates on COVID-19 from the European Centre for Disease Prevention and Control.", "authors": [], "type": "journal article", "published": "2020-02-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "6", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.6.2002131", "pmid": "32070466", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7029450"}], "notes": [], "created": "2020-12-08T06:51:11.110Z", "modified": "2020-12-08T06:51:23.372Z"}, {"entity": "publication", "iuid": "8a6310427b8c4a0ea6204f8c69a060ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a6310427b8c4a0ea6204f8c69a060ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a6310427b8c4a0ea6204f8c69a060ef"}}, "title": "Latest assessment on COVID-19 from the European Centre for Disease Prevention and Control (ECDC).", "authors": [], "type": "journal article", "published": "2020-02-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "8", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.8.2002271", "pmid": "32127126", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7055041"}], "notes": [], "created": "2020-12-08T06:51:46.191Z", "modified": "2020-12-10T09:07:12.084Z"}, {"entity": "publication", "iuid": "4ddd8421feca423ca1949412569cae50", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ddd8421feca423ca1949412569cae50.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ddd8421feca423ca1949412569cae50"}}, "title": "Laboratory readiness and response for novel coronavirus (2019-nCoV) in expert laboratories in 30 EU/EEA countries, January 2020.", "authors": [{"family": "Reusken", "given": "Chantal B E M", "initials": "CBEM"}, {"family": "Broberg", "given": "Eeva K", "initials": "EK"}, {"family": "Haagmans", "given": "Bart", "initials": "B"}, {"family": "Meijer", "given": "Adam", "initials": "A"}, {"family": "Corman", "given": "Victor M", "initials": "VM"}, {"family": "Papa", "given": "Anna", "initials": "A"}, {"family": "Charrel", "given": "Remi", "initials": "R"}, {"family": "Drosten", "given": "Christian", "initials": "C"}, {"family": "Koopmans", "given": "Marion", "initials": "M"}, {"family": "Leitmeyer", "given": "Katrin", "initials": "K"}], "type": "journal article", "published": "2020-02-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "6", "issn-l": null}, "abstract": "Timely detection of novel coronavirus (2019-nCoV) infection cases is crucial to interrupt the spread of this virus. We assessed the required expertise and capacity for molecular detection of 2019-nCoV in specialised laboratories in 30 European Union/European Economic Area (EU/EEA) countries. Thirty-eight laboratories in 24 EU/EEA countries had diagnostic tests available by 29 January 2020. A coverage of all EU/EEA countries was expected by mid-February. Availability of primers/probes, positive controls and personnel were main implementation barriers.", "doi": "10.2807/1560-7917.ES.2020.25.6.2000082", "pmid": "32046815", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7029448"}], "notes": [], "created": "2020-12-10T09:07:15.398Z", "modified": "2020-12-10T09:07:15.407Z"}, {"entity": "publication", "iuid": "18a18e7be6c948a69430c431929b1c8c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18a18e7be6c948a69430c431929b1c8c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18a18e7be6c948a69430c431929b1c8c"}}, "title": "Evaluation of a COVID-19 IgM and IgG rapid test; an efficient tool for assessment of past exposure to SARS-CoV-2", "authors": [{"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Nissen", "given": "Karolina", "initials": "K"}, {"family": "Krambrich", "given": "Janina", "initials": "J"}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B"}, {"family": "Akaberi", "given": "Dario", "initials": "D"}, {"family": "Esmaeilzadeh", "given": "Mouna", "initials": "M"}, {"family": "Salaneck", "given": "Erik", "initials": "E"}, {"family": "Lindahl", "given": "Johanna", "initials": "J"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "journal-article", "published": "2020-01-01", "journal": {"title": "Infect Ecol Epidemiol", "issn": "2000-8686", "issn-l": "2000-8686", "volume": "10", "issue": "1", "pages": "1754538"}, "abstract": "COVID-19 is the most rapidly growing pandemic in modern time, and the need for serological testing is most urgent. Although the diagnostics of acute patients by RT-PCR is both efficient and specific, we are also crucially in need of serological tools for investigating antibody responses and assessing individual and potential herd immunity. We evaluated a commercially available test developed for rapid (within 15 minutes) detection of SARS-CoV-2-specific IgM and IgG by 29 PCR-confirmed COVID-19 cases and 124 negative controls. The results revealed a sensitivity of 69% and 93.1% for IgM and IgG, respectively, based solely on PCR-positivity due to the absence of a serological gold standard. The assay specificities were shown to be 100% for IgM and 99.2% for IgG. This indicates that the test is suitable for assessing previous virus exposure, although negative results may be unreliable during the first weeks after infection. More detailed studies on antibody responses during and post infection are urgently needed.", "doi": "10.1080/20008686.2020.1754538", "pmid": null, "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Imaging": null, "Category: Health": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-04T06:47:15.391Z", "modified": "2021-02-26T08:46:12.946Z"}, {"entity": "publication", "iuid": "835438bc55a64fd2bab901dcb8287ac4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/835438bc55a64fd2bab901dcb8287ac4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/835438bc55a64fd2bab901dcb8287ac4"}}, "title": "Note from the editors: novel coronavirus (2019-nCoV).", "authors": [{"family": "Eurosurveillance editorial team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-01-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "3", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.3.2001231", "pmid": "31992390", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC6988271"}], "notes": [], "created": "2020-12-10T09:07:13.182Z", "modified": "2020-12-10T09:07:13.192Z"}, {"entity": "publication", "iuid": "276c7b56c9bc482782475182bd6bf288", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/276c7b56c9bc482782475182bd6bf288.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/276c7b56c9bc482782475182bd6bf288"}}, "title": "Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS-CoV-2 in an ageing population, consider N-acetylcysteine as early therapeutic intervention", "authors": [{"family": "Nasi", "given": "Aikaterini", "initials": "A", "orcid": "0000-0002-9935-1008", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42e476f1362242ee934f3f2d29c01647.json"}}, {"family": "McArdle", "given": "Stephanie", "initials": "S", "orcid": "0000-0001-6929-9782", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2f69bf332d74e7f814bc12f53c4bca1.json"}}, {"family": "Gaudernack", "given": "Gustav", "initials": "G"}, {"family": "Westman", "given": "Gabriel", "initials": "G"}, {"family": "Melief", "given": "Cornelis", "initials": "C"}, {"family": "Rockberg", "given": "Johan", "initials": "J"}, {"family": "Arens", "given": "Ramon", "initials": "R", "orcid": "0000-0001-5058-4110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/440c6baa3803427fbd9001dfa4725247.json"}}, {"family": "Kouretas", "given": "Demetrios", "initials": "D"}, {"family": "Sj\u00f6lin", "given": "Jan", "initials": "J"}, {"family": "Mangsbo", "given": "Sara", "initials": "S", "orcid": "0000-0002-1355-2678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cf494629d8a4f9584ada4be16dff66b.json"}}], "type": "journal-article", "published": "2020-00-00", "journal": {"title": "Toxicology Reports", "issn": "2214-7500", "issn-l": "2214-7500", "volume": "7", "issue": null, "pages": "768-771"}, "abstract": "During the current COVID-19 pandemic, a need for evaluation of already available drugs for treatment of the disease is crucial. Hereby, based on literature review from the current pandemic and previous outbreaks with corona viruses we analyze the impact of the virus infection on cell stress responses and redox balance. High levels of mortality are noticed in elderly individuals infected with SARS-CoV2 and during the previous SARS-CoV1 outbreak. Elderly individuals maintain a chronic low level of inflammation which is associated with oxidative stress and inflammatory cytokine production, a condition that increases the severity of viral infections in this population. Coronavirus infections can lead to alterations of redox balance in infected cells through modulation of NAD + biosynthesis, PARP function along with altering proteasome and mitochondrial function in the cell thereby leading to enhanced cell stress responses which further exacerbate inflammation. ROS production can increase IL-6 production and lipid peroxidation resulting in cell damage. Therefore, early treatment with anti-oxidants such as NAC during COVID-19 can be a way to bypass the excessive inflammation and cell damage that lead to severe infection, thus early NAC as intervention should be evaluated in a clinical trial setting.", "doi": "10.1016/j.toxrep.2020.06.003", "pmid": "32632359", "labels": {"Funder: KAW/SciLifeLab": null, "Type: Review": null, "Research Area: Drug discovery and repurposing of drugs": null}, "xrefs": [{"db": "pii", "key": "S2214-7500(20)30336-X"}, {"db": "pmc", "key": "PMC7301821"}], "notes": [], "created": "2020-11-04T07:09:44.267Z", "modified": "2022-02-06T17:39:19.668Z"}, {"entity": "publication", "iuid": "2ecd356aee194db0b6de668cf27aac00", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ecd356aee194db0b6de668cf27aac00.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ecd356aee194db0b6de668cf27aac00"}}, "title": "Principles of mental health care during the COVID-19 pandemic", "authors": [{"family": "Kuzman", "given": "Martina Rojnic", "initials": "MR", "orcid": "0000-0001-9646-0594", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fad1012ef6d4d528af166ab01e06c9d.json"}}, {"family": "Curkovic", "given": "Marko", "initials": "M", "orcid": "0000-0002-4855-2133", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29ca35067e324a22839263700264ecab.json"}}, {"family": "Wasserman", "given": "Danuta", "initials": "D"}], "type": "journal-article", "published": "2020-00-00", "journal": {"title": "Eur Psychiatry", "issn": "0924-9338", "volume": "63", "issue": "1", "pages": "e45", "issn-l": null}, "abstract": "We describe the basic principles of mental health care during the COVID-19 pandemic that should be endorsed by the mental health professional associations and incorporated in the health strategies for the management of the COVID-19 pandemic. The main principle is that there should be no substantial differences in the provision of health care for COVID-19 between persons with pre-existing mental health disorders and the ones without previous disorders. Subsequently, the organization of the health care should reflect that as well. These principles should (a) prevent the possible effects of stigmatizing attitudes toward mental health issues, possibly leading to potentially deleterious situations, such as psychiatric patients being treated (even temporarily) separately from other patients, in psychiatric facilities, where the staff is not equipped and trained adequately for the management of COVID-19; (b) highlight the fact that patients with mental health disorders are at greater risk for developing serious complications of COVID-19 infection due to other factors-they often smoke and have comorbidities such as hypertension, diabetes, all associated with higher morbidity and mortality from COVID-19 infection; (c) highlight that measures should be taken to minimize the risk of the spread of infection in psychiatric wards/institutions; (d) provide a general framework for the reorganization of mental health services toward the provision of services for persons in need, including frontline medical workers and patients with COVID-19 without previous mental health problems as well as for persons with pre-existing mental health problems under new circumstances of pandemic.", "doi": "10.1192/j.eurpsy.2020.54", "pmid": "32431255", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0924933820000541"}, {"db": "pmc", "key": "PMC7267055"}], "notes": [], "created": "2020-11-25T09:08:56.007Z", "modified": "2021-12-06T13:17:17.161Z"}, {"entity": "publication", "iuid": "2255c0c2ec314e95ab1e0d30d475f231", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2255c0c2ec314e95ab1e0d30d475f231.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2255c0c2ec314e95ab1e0d30d475f231"}}, "title": "COVID-19: A case report from Bangladesh perspective", "authors": [{"family": "Jahan", "given": "Yasmin", "initials": "Y"}, {"family": "Rahman", "given": "Sohel", "initials": "S"}, {"family": "Rahman", "given": "Atiqur", "initials": "A"}], "type": "journal-article", "published": "2020-00-00", "journal": {"title": "Respir Med Case Rep", "issn": "2213-0071", "volume": "30", "issue": null, "pages": "101068", "issn-l": null}, "abstract": "A 34-year-old man without any significant medical history or comorbidities, suddenly developed fever, and shortness of breath, thereby admitted to the emergency department of a tertiary care hospital, Dhaka, Bangladesh. He had neither a history of traveling to Coronavirus disease (COVID) prone areas nor a direct contact of COVID positive patients. His chest X-ray revealed ground-glass opacity in the right middle and lower zone of the lung. The first polymerase chain reaction (PCR) test on throat and nasal swabs for the COVID upon admission was negative. Based on the chest X-ray result, RT-PCR was done again resulted positive. The patient was primarily treated with chloroquine and azithromycin. On full recovery, he was discharged from the hospital on day 12, after two subsequent throat swab samples tested negative by PCR (24 hours apart). He was encouraged to maintain home quarantine for at least the next 14 days. SARS-CoV-2 RNA by swab remained negative and the blood sample shows the presence of antibody (both IgM and IgG) in his follow-up visit (after 7 days of hospital discharge).", "doi": "10.1016/j.rmcr.2020.101068", "pmid": "32363143", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7194830"}, {"db": "pii", "key": "S2213-0071(20)30173-8"}, {"db": "pii", "key": "101068"}], "notes": [], "created": "2020-12-10T07:25:21.814Z", "modified": "2021-12-06T12:57:00.418Z"}]}
\ No newline at end of file
+{"entity": "publications", "timestamp": "2023-12-08T06:32:26.705Z", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publications.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publications"}}, "publications_count": 3459, "full": true, "publications": [{"entity": "publication", "iuid": "a5a5288d35b84c81a7211dc46aa3f8f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a5a5288d35b84c81a7211dc46aa3f8f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a5a5288d35b84c81a7211dc46aa3f8f9"}}, "title": "Confidence in COVID-19 vaccine effectiveness and safety and its effect on vaccine uptake in Tanzania: A community-based cross-sectional study.", "authors": [{"family": "Mtei", "given": "Monica", "initials": "M", "orcid": "0000-0002-0407-6593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0880cf78afbb447e9af763d5fcc063b6.json"}}, {"family": "Mboya", "given": "Innocent B", "initials": "IB"}, {"family": "Mgongo", "given": "Melina", "initials": "M"}, {"family": "Manongi", "given": "Rachel", "initials": "R"}, {"family": "Amour", "given": "Caroline", "initials": "C"}, {"family": "Bilakwate", "given": "Julieth S", "initials": "JS"}, {"family": "Nyaki", "given": "Ahmed Y", "initials": "AY"}, {"family": "Ngocho", "given": "James", "initials": "J"}, {"family": "Jonas", "given": "Norman", "initials": "N"}, {"family": "Farah", "given": "Amina", "initials": "A"}, {"family": "Amour", "given": "Maryam", "initials": "M"}, {"family": "Kalolo", "given": "Albino", "initials": "A"}, {"family": "Kengia", "given": "James T", "initials": "JT"}, {"family": "Tinuga", "given": "Florian", "initials": "F"}, {"family": "Ngalesoni", "given": "Frida", "initials": "F"}, {"family": "Bakari", "given": "Abdalla H", "initials": "AH"}, {"family": "Kirakoya", "given": "Fatimata B", "initials": "FB"}, {"family": "Araya", "given": "Awet", "initials": "A"}, {"family": "Kapologwe", "given": "Ntuli A", "initials": "NA"}, {"family": "Msuya", "given": "Sia E", "initials": "SE"}], "type": "journal article", "published": "2023-12-31", "journal": {"title": "Hum Vaccin Immunother", "issn": "2164-554X", "volume": "19", "issue": "1", "pages": "2191576", "issn-l": null}, "abstract": "COVID-19 is a major public health threat associated with increased disease burden, mortality, and economic loss to countries and communities. Safe and efficacious COVID-19 vaccines are key in halting and reversing the pandemic. Low confidence in vaccines has been one of the factors leading to hesitancy. We aimed to assess the COVID-19 vaccine confidence (safety and effectiveness), associated factors, and its effects on vaccine uptake among general community members in Tanzania. This was a community-based cross-sectional survey conducted from December 2021 to April 2022 in six regions of Tanzania mainland and two regions in Zanzibar. Participants were interviewed using an electronic questionnaire. Multiple logistic regression models estimated odds ratios (ORs) and 95% confidence interval (CI) for factors associated with vaccine confidence. All analyses were performed using SPSS version 25.0. The study enrolled 3470 general Tanzanian community members; their mean age was 40.3 (standard deviation \u00b114.9) years, and 34% were males. The proportion of COVID-19 vaccine confidence was 54.6%. Geographical region, residence area, COVID-19 disease risk perception, and good knowledge of COVID-19 vaccines were significantly associated with COVID-19 vaccine confidence. Confidence in COVID-19 vaccines was associated with over three times higher odds of vaccine uptake. Confidence in COVID-19 vaccines was low in Tanzania. Innovative community engagement strategies and region-specific interventions are needed to improve comprehensive knowledge and address community perceptions and attitudes toward COVID-19 vaccines.", "doi": "10.1080/21645515.2023.2191576", "pmid": "37017234", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10088920"}], "notes": [], "created": "2023-04-20T17:33:21.814Z", "modified": "2023-04-20T17:33:21.864Z"}, {"entity": "publication", "iuid": "e51c2b2f8cfd4821b00b9ade72030dce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e51c2b2f8cfd4821b00b9ade72030dce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e51c2b2f8cfd4821b00b9ade72030dce"}}, "title": "The influence of the Covid-19 pandemic on municipal meeting places arranging group exercise for older persons.", "authors": [{"family": "Dinse", "given": "Daniella", "initials": "D", "orcid": "0000-0002-4756-6728", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4aaa7aafbba646a39fabc6bb5c708549.json"}}, {"family": "Haak", "given": "Maria", "initials": "M", "orcid": "0000-0002-0054-2542", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b94642fc4c14e8991de97ae05cf49dc.json"}}, {"family": "Nilsson", "given": "Marie", "initials": "M", "orcid": "0000-0003-2762-7041", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6065be7342ee4a0786a7eb5ef9ed074c.json"}}, {"family": "Karlsson", "given": "Staffan", "initials": "S", "orcid": "0000-0002-6624-9963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e647df4e8b2455e939b74098c4a63c3.json"}}, {"family": "Olsson M\u00f6ller", "given": "Ulrika", "initials": "U", "orcid": "0000-0002-6879-9563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62ee4ccae36d4217a611c09fbfcea041.json"}}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Int J Qual Stud Health Well-being", "issn": "1748-2631", "issn-l": null, "volume": "18", "issue": "1", "pages": "2235130"}, "abstract": "Many municipalities today, together with other stakeholders, offer group exercises for the older population via municipal meeting places, focusing on promoting good health. During the Covid-19 pandemic, these group exercises either continued in a modified form or ceased. The aim of this study was to explore involved stakeholders' experiences of group exercises for older persons arranged via municipal meeting places during the Covid-19 pandemic.\r\n\r\nSix online focus group interviews were conducted with 25 stakeholders, such as decision-makers and representatives from the non-profit sector, from seven municipalities in Sweden. Data were analysed using thematic analysis.\r\n\r\nThe collaboration around the group exercises was challenged due to affected communication and decision-making. The stakeholders described the importance of adapting and finding new ways to offer group exercise. Furthermore, the re-arranging of group exercises created concerns about the well-being of the older persons but also happiness with the older persons ability to act for their own well-being during the pandemic.\r\n\r\nThis study highlights the importance of the municipalities exchanging experiences, making the older persons more involved in the decision-making process, enabling a person-centred encounter with the older persons when exercising in groups, and strengthening supportive environments by sharing the ownership of arranging the group exercises with the older persons.", "doi": "10.1080/17482631.2023.2235130", "pmid": "37499132", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10375932"}], "notes": [], "created": "2023-10-04T12:08:42.317Z", "modified": "2023-10-04T12:39:04.249Z"}, {"entity": "publication", "iuid": "2c7332149f534505b1cd8b604e924b12", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c7332149f534505b1cd8b604e924b12.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c7332149f534505b1cd8b604e924b12"}}, "title": "The experiences of patients ill with COVID-19-like symptoms and the role of testing for SARS-CoV-2 in supporting them: A qualitative study in eight European countries during the first wave of the pandemic.", "authors": [{"family": "Hoste", "given": "Melanie E", "initials": "ME", "orcid": "0000-0003-0831-3354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2e7d9961a0d486db33addd840a2f827.json"}}, {"family": "Wanat", "given": "Marta", "initials": "M"}, {"family": "Gobat", "given": "Nina", "initials": "N"}, {"family": "Anastasaki", "given": "Marilena", "initials": "M"}, {"family": "B\u00f6hmer", "given": "Femke", "initials": "F"}, {"family": "Chlabicz", "given": "S\u0142awomir", "initials": "S"}, {"family": "Colliers", "given": "Annelies", "initials": "A", "orcid": "0000-0003-4960-2355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/da75d309875249ab927e572db2b3ec91.json"}}, {"family": "Farrell", "given": "Karen", "initials": "K"}, {"family": "Karkana", "given": "Maria-Nefeli", "initials": "M"}, {"family": "Kinsman", "given": "John", "initials": "J"}, {"family": "Lionis", "given": "Christos", "initials": "C", "orcid": "0000-0002-9324-2839", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4f78c9751aa4b288a80e6dd903f3f56.json"}}, {"family": "Marcinowicz", "given": "Ludmila", "initials": "L"}, {"family": "Reinhardt", "given": "Katrin", "initials": "K"}, {"family": "Skoglund", "given": "Ingmarie", "initials": "I"}, {"family": "Sundvall", "given": "P\u00e4r-Daniel", "initials": "P"}, {"family": "Vellinga", "given": "Akke", "initials": "A", "orcid": "0000-0002-6583-4300", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84b752b8202048bca41ca262b5536985.json"}}, {"family": "Goossens", "given": "Herman", "initials": "H"}, {"family": "Butler", "given": "Christopher C", "initials": "CC"}, {"family": "van der Velden", "given": "Alike", "initials": "A"}, {"family": "Tonkin-Crine", "given": "Sarah", "initials": "S"}, {"family": "Anthierens", "given": "Sibyl", "initials": "S"}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Eur J Gen Pract", "issn": "1751-1402", "issn-l": null, "volume": "29", "issue": "2", "pages": "2212904"}, "abstract": "Access to testing during the first wave of the COVID-19 pandemic was limited, impacting patients with COVID-19-like symptoms. Current qualitative studies have been limited to one country or were conducted outside Europe.\r\n\r\nTo explore - in eight European countries - the experiences of patients consulting in primary care with COVID-19-like symptoms during the first wave of the pandemic.\r\n\r\nSixty-six semi-structured interviews, informed by a topic guide, were conducted by telephone or in person between April and July 2020. Patients with COVID-19-like symptoms were purposively recruited in primary care sites in eight countries and sampled based on age, gender, and symptom presentation. Deductive and inductive thematic analysis techniques were used to develop a framework representing data across settings. Data adequacy was attained by collecting rich data.\r\n\r\nSeven themes were identified, which described the experiences of patients consulting. Two themes are reported in this manuscript describing the role of COVID-19 testing in this experience. Patients described significant distress due to their symptoms, especially those at higher risk of complications from COVID-19, and those with severe symptoms. Patients wanted access to testing to identify the cause of their illness and minimise the burden of managing uncertainty. Some patients testing positive for COVID-19 assumed they would be immune from future infection.\r\n\r\nPatients experiencing novel and severe symptoms, particularly those with comorbidities, experienced a significant emotional and psychological burden due to concerns about COVID-19. Testing provided reassurance over health status and helped patients identify which guidance to follow. Testing positive for SARS-CoV-2 led to some patients thinking they were immune from future infection, thus influencing subsequent behaviour.", "doi": "10.1080/13814788.2023.2212904", "pmid": "37248990", "labels": {"Category: Social Science & Humanities": null, "Funder: H2020": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10249444"}], "notes": [], "created": "2023-10-04T05:08:51.674Z", "modified": "2023-10-04T05:30:49.922Z"}, {"entity": "publication", "iuid": "5479327ce61d4dd39f99c46c502b7f4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5479327ce61d4dd39f99c46c502b7f4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5479327ce61d4dd39f99c46c502b7f4c"}}, "title": "The distorted memories of patients treated in the intensive care unit during the COVID-19 pandemic: A qualitative study.", "authors": [{"family": "Vogel", "given": "Gisela", "initials": "G"}, {"family": "Forinder", "given": "Ulla", "initials": "U"}, {"family": "Sandgren", "given": "Anna", "initials": "A"}, {"family": "Svensen", "given": "Christer", "initials": "C"}, {"family": "Joelsson-Alm", "given": "Eva", "initials": "E"}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "issn-l": null, "volume": "79", "issue": null, "pages": "103522"}, "abstract": "During the COVID-19 pandemic, patients cared for in the intensive care unit were exposed to many risk factors for developing delirium and subsequent distorted memories. Further, seeing healthcare professionals who have been dressed in personal protective equipment and face masks could have affected the patients' memories. Therefore, the aim of this study was to explore memories and how they are experienced and managed by former patients who have been treated for COVID-19 in an intensive care unit.\r\n\r\nSixteen former patients treated for COVID-19 at a large emergency hospital in Sweden were interviewed 3-8 months after discharge from the intensive care unit. The data were interpreted using thematic analysis. The Consolidated Criteria for Reporting Qualitative Research checklist was followed in the reporting of the study.\r\n\r\nParticipants' descriptions of their memories of treatment in the intensive care unit for COVID-19 generated three themes: 'Distorted truth' the content in the memories which implied facing death in an unreal distorted environment. 'Captive,' was the experience and feelings linked to memories with a feeling of being exposed and alone, and 'Coping with memories' explained how participants managed the implications of the memories using a mixture of strategies.\r\n\r\nFor former patients who were admitted to an intensive care unit after a diagnosis of COVID-19, memories caused considerable distress, which were similar to other intensive care patient\u015b experiences, before the pandemic. Emotion-focused and problem-focused strategies could be used to cope with these memories. Healthcare professionals wearing protective equipment gave the patient a distant feeling, but more important was to be treated with attention/care and respect.\r\n\r\nAwareness of the impact of distorted memories on patients who are severely ill and their needs and strategies to cope with these memories can form the basis for early interventions that promotes well-being during care and recovery. Healthcare professionals have an important task to inform patients and their family members about the existence of distorted memories, and talk about the patients' experience of them, to facilitate their recovery.", "doi": "10.1016/j.iccn.2023.103522", "pmid": "37598502", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(23)00139-8"}], "notes": [], "created": "2023-10-05T08:08:44.568Z", "modified": "2023-10-06T04:33:26.762Z"}, {"entity": "publication", "iuid": "9f64fedc77734b37992314525f43aa19", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f64fedc77734b37992314525f43aa19.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f64fedc77734b37992314525f43aa19"}}, "title": "The association of insomnia with long COVID: An international collaborative study (ICOSS-II).", "authors": [{"family": "Chen", "given": "Si-Jing", "initials": "S"}, {"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "Ivers", "given": "Hans", "initials": "H"}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "Merikanto", "given": "Ilona", "initials": "I"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Espie", "given": "Colin A", "initials": "CA"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L"}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y"}, {"family": "Chung", "given": "Frances", "initials": "F"}, {"family": "Yordanova", "given": "Juliana", "initials": "J"}, {"family": "Vidovi\u0107", "given": "Domagoj", "initials": "D"}, {"family": "Reis", "given": "Catia", "initials": "C"}, {"family": "Plazzi", "given": "Giuseppe", "initials": "G"}, {"family": "Penzel", "given": "Thomas", "initials": "T"}, {"family": "Nadorff", "given": "Michael R", "initials": "MR"}, {"family": "Matsui", "given": "Kentaro", "initials": "K"}, {"family": "Mota-Rolim", "given": "Sergio", "initials": "S"}, {"family": "Leger", "given": "Damien", "initials": "D"}, {"family": "Landtblom", "given": "Anne-Marie", "initials": "A"}, {"family": "Korman", "given": "Maria", "initials": "M"}, {"family": "Inoue", "given": "Yuichi", "initials": "Y"}, {"family": "Hrubos-Str\u00f8m", "given": "Harald", "initials": "H"}, {"family": "Chan", "given": "Ngan Yin", "initials": "NY"}, {"family": "Bjelajac", "given": "Adrijana Koscec", "initials": "AK"}, {"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Sleep Med", "issn": "1878-5506", "issn-l": null, "volume": "112", "issue": null, "pages": "216-222"}, "abstract": "There is evidence of a strong association between insomnia and COVID-19, yet few studies have examined the relationship between insomnia and long COVID. This study aimed to investigate whether COVID-19 patients with pre-pandemic insomnia have a greater risk of developing long COVID and whether long COVID is in turn associated with higher incident rates of insomnia symptoms after infection.\r\n\r\nData were collected cross-sectionally (May-Dec 2021) as part of an international collaborative study involving participants from 16 countries. A total of 2311 participants (18-99 years old) with COVID-19 provided valid responses to a web-based survey about sleep, insomnia, and health-related variables. Log-binomial regression was used to assess bidirectional associations between insomnia and long COVID. Analyses were adjusted for age, sex, and health conditions, including sleep apnea, attention and memory problems, chronic fatigue, depression, and anxiety.\r\n\r\nCOVID-19 patients with pre-pandemic insomnia showed a higher risk of developing long COVID than those without pre-pandemic insomnia (70.8% vs 51.4%; adjusted relative risk [RR]: 1.33, 95% confidence interval [CI]: 1.07-1.65). Among COVID-19 cases without pre-pandemic insomnia, the rates of incident insomnia symptoms after infection were 24.1% for short COVID cases and 60.6% for long COVID cases (p < .001). Compared with short COVID cases, long COVID cases were associated with an increased risk of developing insomnia symptoms (adjusted RR: 2.00; 95% CI: 1.50-2.66).\r\n\r\nThe findings support a bidirectional relationship between insomnia and long COVID. These findings highlight the importance of addressing sleep and insomnia in the prevention and management of long COVID.", "doi": "10.1016/j.sleep.2023.09.034", "pmid": "37922783", "labels": {"Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1389-9457(23)00367-2"}], "notes": [], "created": "2023-12-04T07:21:13.017Z", "modified": "2023-12-04T08:13:40.918Z"}, {"entity": "publication", "iuid": "df1add79ba144dcc955eab39d23f0571", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/df1add79ba144dcc955eab39d23f0571.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/df1add79ba144dcc955eab39d23f0571"}}, "title": "Tailored internet-based psychological treatment for psychological problems during the COVID-19 pandemic: A randomized controlled trial.", "authors": [{"family": "Aminoff", "given": "Victoria", "initials": "V"}, {"family": "Bobeck", "given": "Johanna", "initials": "J"}, {"family": "Hjort", "given": "Sofia", "initials": "S"}, {"family": "S\u00f6rliden", "given": "Elise", "initials": "E"}, {"family": "Ludvigsson", "given": "Mikael", "initials": "M"}, {"family": "Berg", "given": "Matilda", "initials": "M"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Internet Interv", "issn": "2214-7829", "issn-l": "2214-7829", "volume": "34", "issue": null, "pages": "100662"}, "abstract": "The COVID-19 pandemic influence mental health in both infected and non-infected populations. In this study we examined if individually tailored internet-based cognitive behavioral therapy (ICBT) could be an effective treatment for psychological symptoms related to the pandemic. Following recruitment we included 76 participants who were randomized to either a treatment group (n = 37) or a waitlist control group (n = 39). The treatment group received 8 modules (out of 16 possible) during 8 weeks with weekly therapist support. We collected data on symptoms of depression, experienced quality of life, anxiety, stress, anger, insomnia, PTSD, and alcohol use before, after the treatment and at one year follow-up. Using multiple regression analysis, group condition was found to be a statistically significant predictor for a decrease, favoring the treatment group, in symptoms of depression, insomnia, and anger with small to moderate effect sizes. The improvements remained at one year follow-up. Group condition did not significantly predict changing symptoms regarding experienced quality of life, anxiety, stress, PTSD and alcohol use. Findings indicate that ICBT is an effective intervention for some psychological symptoms associated with the COVID-19 pandemic. There is a need for further studies on mechanisms of change and on tailored ICBT for problems associated with crises like the pandemic.", "doi": "10.1016/j.invent.2023.100662", "pmid": "37671335", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10475474"}, {"db": "pii", "key": "S2214-7829(23)00062-3"}], "notes": [], "created": "2023-10-06T06:56:36.372Z", "modified": "2023-10-06T11:19:54.405Z"}, {"entity": "publication", "iuid": "d8627c522c93438bab63f8c22c362e8c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d8627c522c93438bab63f8c22c362e8c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d8627c522c93438bab63f8c22c362e8c"}}, "title": "Public health restrictions, directives, and measures in Arctic countries in the first year of the COVID-19 pandemic.", "authors": [{"family": "Peterson", "given": "Malory", "initials": "M", "orcid": "0000-0001-9730-899X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/535cfc55eb4245238a543ceae4955aa0.json"}}, {"family": "Akearok", "given": "Gwen Healey", "initials": "GH", "orcid": "0000-0001-9507-2610", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d74acdff0470400cb32d8790f4c44c6a.json"}}, {"family": "Cueva", "given": "Katie", "initials": "K", "orcid": "0000-0002-8013-9680", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d904d970c544a9fb4a51aa0b54a3d07.json"}}, {"family": "Lavoie", "given": "Jos\u00e9e G", "initials": "JG", "orcid": "0000-0003-2483-431X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/979bb18295514ce28f361f6479080b98.json"}}, {"family": "Larsen", "given": "Christina Vl", "initials": "CV", "orcid": "0000-0002-6245-4222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/122c1ea2512947258ee6e0b3c727651e.json"}}, {"family": "J\u00f3hannsd\u00f3ttir", "given": "L\u00e1ra", "initials": "L", "orcid": "0000-0001-5912-3337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6cd00a909ab4a7fae2beb9765eaa4b6.json"}}, {"family": "Cook", "given": "David", "initials": "D", "orcid": "0000-0001-9200-0515", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0e0ad34240445e78514fd55ce6e76fa.json"}}, {"family": "Nilsson", "given": "Lena Maria", "initials": "LM", "orcid": "0000-0002-2354-7258", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1dc6f1b33370474f9ad51f370d9cf3c3.json"}}, {"family": "Rautio", "given": "Arja", "initials": "A", "orcid": "0000-0002-5816-533X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07a185cd1ef3427b9f49847cbd268617.json"}}, {"family": "Timlin", "given": "Ulla", "initials": "U", "orcid": "0000-0002-7840-4430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a0fcd3b9cb94ca58b719ed94812c719.json"}}, {"family": "San Sebasti\u00e1n", "given": "Miguel", "initials": "M", "orcid": "0000-0001-7234-3510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e7ccb93844f4bd6aba400b70261d37b.json"}}, {"family": "Gladun", "given": "Elena", "initials": "E", "orcid": "0000-0003-2525-6638", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/180f54a51ddc4c3ca988012e0c98a604.json"}}, {"family": "Rink", "given": "Elizabeth", "initials": "E", "orcid": "0000-0002-5738-5496", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5578d7332c574ea4988f8d94a988138b.json"}}, {"family": "Broderstadt", "given": "Ann Ragnhild", "initials": "AR", "orcid": "0000-0003-3843-6953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4de647a328304fd0be8fd6f308758d48.json"}}, {"family": "Dagsvold", "given": "Inger", "initials": "I"}, {"family": "Siri", "given": "Susanna", "initials": "S", "orcid": "0000-0003-3231-8139", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fa098be57c24667a8e4ffa526d1f12f.json"}}, {"family": "Ottendahl", "given": "Charlotte Brandstrup", "initials": "CB", "orcid": "0000-0002-9285-3099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c6f92de274540a0b3ad587252e69425.json"}}, {"family": "Olesen", "given": "Ingelise", "initials": "I"}, {"family": "Zatseva", "given": "Larisa", "initials": "L"}, {"family": "Young", "given": "Rebecca Ipiaqruk", "initials": "RI", "orcid": "0009-0009-3502-1147", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db8a63fdb6f84bf6875a32f57a066840.json"}}, {"family": "Chaliak", "given": "Ay'aqulluk Jim", "initials": "AJ", "orcid": "0009-0003-0559-0871", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba18ca8951c14fbba3f58123107f15ba.json"}}, {"family": "Ophus", "given": "Emily", "initials": "E"}, {"family": "Stoor", "given": "Jon Petter A", "initials": "JPA", "orcid": "0000-0002-1580-8307", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61077580fa204d84ada7e7cdc395dadc.json"}}], "type": "review", "published": "2023-12-00", "journal": {"title": "Int J Circumpolar Health", "issn": "2242-3982", "issn-l": null, "volume": "82", "issue": "1", "pages": "2271211"}, "abstract": "Beginning January of 2020, COVID-19 cases detected in Arctic countries triggered government policy responses to stop transmission and limit caseloads beneath levels that would overwhelm existing healthcare systems. This review details the various restrictions, health mandates, and transmission mitigation strategies imposed by governments in eight Arctic countries (the United States, Canada, Greenland, Norway, Finland, Sweden, Iceland, and Russia) during the first year of the COVID-19 pandemic, through 31 January 2021s31 January 2021. We highlight formal protocols and informal initiatives adopted by local communities in each country, beyond what was mandated by regional or national governments. This review documents travel restrictions, communications, testing strategies, and use of health technology to track and monitor COVID-19 cases. We provide geographical and sociocultural background and draw on local media and communications to contextualise the impact of COVID-19 emergence and prevention measures in Indigenous communities in the Arctic. Countries saw varied case rates associated with local protocols, governance, and population. Still, almost all regions maintained low COVID-19 case rates until November of 2020. This review was produced as part of an international collaboration to identify community-driven, evidence-based promising practices and recommendations to inform pan-Arctic collaboration and decision making in public health during global emergencies.", "doi": "10.1080/22423982.2023.2271211", "pmid": "37898999", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:32:19.806Z", "modified": "2023-12-08T06:22:42.187Z"}, {"entity": "publication", "iuid": "b884f27250514663a9b65039859959f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b884f27250514663a9b65039859959f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b884f27250514663a9b65039859959f7"}}, "title": "Prevalence and factors associated with healthcare avoidance during the COVID-19 pandemic among the S\u00e1mi in Sweden: the S\u00e1miHET study.", "authors": [{"family": "Dresse", "given": "Menayit Tamrat", "initials": "MT", "orcid": "0000-0003-4830-8242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/16cf2e49e4234a4294b5b9ab46f57487.json"}}, {"family": "Stoor", "given": "Jon Petter", "initials": "JP", "orcid": "0000-0002-1580-8307", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61077580fa204d84ada7e7cdc395dadc.json"}}, {"family": "San Sebastian", "given": "Miguel", "initials": "M", "orcid": "0000-0001-7234-3510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e7ccb93844f4bd6aba400b70261d37b.json"}}, {"family": "Nilsson", "given": "Lena Maria", "initials": "LM", "orcid": "0000-0002-2354-7258", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1dc6f1b33370474f9ad51f370d9cf3c3.json"}}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Int J Circumpolar Health", "issn": "2242-3982", "issn-l": null, "volume": "82", "issue": "1", "pages": "2213909"}, "abstract": "The aim of this population-based cross-sectional study was to assess the prevalence of healthcare avoidance during the COVID-19 pandemic and its associated factors among the S\u00e1mi population in Sweden. Data from the \"S\u00e1mi Health on Equal Terms\" (S\u00e1miHET) survey conducted in 2021 were used. Overall, 3,658 individuals constituted the analytical sample. Analysis was framed using the social determinants of health framework. The association between healthcare avoidance and several sociodemographic, material, and cultural factors was explored through log-binomial regression analyses. Sampling weights were applied in all analyses. Thirty percent of the S\u00e1mi in Sweden avoided healthcare during the COVID-19 pandemic. S\u00e1mi women (PR: 1.52, 95% CI: 1.36-1.70), young adults (PR: 1.22, 95% CI:1.05-1.47), S\u00e1mi living outside S\u00e1pmi (PR: 1.17, 95% CI: 1.03-1.34), and those having low income (PR: 1.42, 95% CI:1.19-1.68) and experiencing economic stress (PR: 1.48, 95% CI: 1.31-1.67) had a higher prevalence of healthcare avoidance. The pattern shown in this study can be useful for planning future pandemic responses, which should address healthcare avoidance, particularly among the identified vulnerable groups, including the active participation of the S\u00e1mi themselves.", "doi": "10.1080/22423982.2023.2213909", "pmid": "37216571", "labels": {"Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10208175"}], "notes": [], "created": "2023-10-04T05:09:51.425Z", "modified": "2023-10-04T06:18:54.180Z"}, {"entity": "publication", "iuid": "4b91c5e8663548b2a09a41385d1c5d92", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b91c5e8663548b2a09a41385d1c5d92.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b91c5e8663548b2a09a41385d1c5d92"}}, "title": "Low-intensity online mindfulness-based intervention for university students with anxiety during the COVID-19 pandemic-A randomized controlled trial with 3-month follow-up.", "authors": [{"family": "Young", "given": "Daniel Kim-Wan", "initials": "DK"}, {"family": "Carlbring", "given": "Per", "initials": "P"}, {"family": "Ng", "given": "Petrus Yat-Nam", "initials": "PY"}, {"family": "Cheng", "given": "Daphne Yi Ting", "initials": "DYT"}, {"family": "Chen", "given": "Joseph Qi-Rong", "initials": "JQ"}, {"family": "Ng", "given": "Siu-Man", "initials": "S"}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Internet Interv", "issn": "2214-7829", "issn-l": "2214-7829", "volume": "34", "issue": null, "pages": "100665"}, "abstract": "This study investigated the effectiveness of a low-intensity online mindfulness-based Intervention (iMBI) for alleviating anxiety in university students during the COVID-19 pandemic.\r\n\r\nIn a randomized controlled trial involving 134 participants from a local university in Hong Kong, subjects were randomly assigned to either the intervention group (n = 67) or the inactive control group (n = 67). The intervention group participated in a low-intensity iMBI comprising 16 online modules and two half-day online mindfulness workshops over an eight-week period. Outcomes were measured via an online platform using standardized assessment scales, including the Beck Anxiety Inventory and the Chinese Five Facets Mindfulness Questionnaire, at three different time points: pre-intervention, post-intervention and at a three-month follow-up.\r\n\r\nIntent-to-treat analysis using 2 (group) \u00d7 3 (time) repeated measures of covariance (ANCOVA) showed that the intervention group, compared to the control group, showed a significant reduction in anxiety symptoms with a medium effect size (Cohen's d = 0.5) and a significant improvement in mindfulness skills with a medium effect size (Cohen's d = 0.5) at post-intervention. The effects of the intervention in reducing anxiety and improving mindfulness persisted at the three-month follow-up.\r\n\r\nThe results of this study demonstrate the effectiveness of the low-intensity iMBI in alleviating anxiety among university students.", "doi": "10.1016/j.invent.2023.100665", "pmid": "37840645", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10569980"}, {"db": "pii", "key": "S2214-7829(23)00065-9"}], "notes": [], "created": "2023-11-01T13:34:14.816Z", "modified": "2023-11-02T07:44:47.549Z"}, {"entity": "publication", "iuid": "182d836242834bf391e3c43c66a4141d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/182d836242834bf391e3c43c66a4141d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/182d836242834bf391e3c43c66a4141d"}}, "title": "GLD-SAIPAR Covid-19 survey in Zambia dataset.", "authors": [{"family": "Metheney", "given": "Erica Ann", "initials": "EA"}, {"family": "Lust", "given": "Ellen", "initials": "E"}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Data Brief", "issn": "2352-3409", "issn-l": null, "volume": "51", "issue": null, "pages": "109735"}, "abstract": "In March 2020, Zambia reported their first cases of Covid-19, with the government restricting non-essential travel, banning large public gatherings, and establishing emergency committees to spearhead efforts to contain the pandemic at a national level. The Governance and Local Development Institute (GLD) in collaboration with South African Institute for Policy and Research (SAIPAR) implemented a survey in 2020 to generate a dataset to provide better understanding of citizens' responses to such measures, and the impact of the pandemic on their individual lives and communities. To generate as complete a picture as possible of the local situations over time, we conducted two survey rounds. These rounds resulted in a total of 3925 completed surveys (1022 respondents took both rounds), gathering information on issues including knowledge of Covid-19; attitudes and fears surrounding health and economic impacts; social, economic, and health vulnerabilities; social distancing practices and other preventative measures. Particular attention was paid to the local variation in concerns over the social stigma, levels of enforcement, and engagement of different authorities.", "doi": "10.1016/j.dib.2023.109735", "pmid": "37965609", "labels": {"Category: Social Science & Humanities": null, "Funder: VR": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10641148"}, {"db": "pii", "key": "S2352-3409(23)00804-1"}], "notes": [], "created": "2023-12-04T07:19:29.522Z", "modified": "2023-12-08T06:21:43.891Z"}, {"entity": "publication", "iuid": "a7f18fab206d4d86aa561ea378cbcee3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7f18fab206d4d86aa561ea378cbcee3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7f18fab206d4d86aa561ea378cbcee3"}}, "title": "Effects of fine particulate matter (PM2.5) and meteorological factors on the daily confirmed cases of COVID-19 in Bangkok during 2020\u20132021, Thailand", "authors": [{"family": "Sangkham", "given": "Sarawut", "initials": "S", "orcid": "0000-0002-0507-0177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/156042be10a148acbf5fddef6e7b3b6f.json"}}, {"family": "Islam", "given": "Md Aminul", "initials": "MA"}, {"family": "Sarndhong", "given": "Kritsada", "initials": "K"}, {"family": "Vongruang", "given": "Patipat", "initials": "P"}, {"family": "Hasan", "given": "Mohammad Nayeem", "initials": "MN"}, {"family": "Tiwari", "given": "Ananda", "initials": "A"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}], "type": "journal-article", "published": "2023-12-00", "journal": {"title": "Case Studies in Chemical and Environmental Engineering", "issn": "2666-0164", "issn-l": null, "volume": "8", "issue": null, "pages": "100410"}, "abstract": null, "doi": "10.1016/j.cscee.2023.100410", "pmid": null, "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:33:28.320Z", "modified": "2023-10-04T09:41:09.413Z"}, {"entity": "publication", "iuid": "f95d3431743140bd81bff9689e633b9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f95d3431743140bd81bff9689e633b9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f95d3431743140bd81bff9689e633b9c"}}, "title": "Adolescents' and young people's experiences of social relationships and health concerns during COVID-19.", "authors": [{"family": "Sundler", "given": "Annelie J", "initials": "AJ", "orcid": "0000-0002-9194-3244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7308e89c2f4840268add7c61d26e3fbb.json"}}, {"family": "Bergnehr", "given": "Disa", "initials": "D", "orcid": "0000-0002-6357-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/524674f9584741db8884173f5a79cad3.json"}}, {"family": "Haffejee", "given": "Sadiyya", "initials": "S", "orcid": "0000-0002-9513-6861", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adb65c4ef1ee434caf5e5d7072480208.json"}}, {"family": "Iqbal", "given": "Humera", "initials": "H", "orcid": "0000-0002-3437-3759", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5185c706da4645b2b876109b656311f1.json"}}, {"family": "Orellana", "given": "Marjorie Faulstich", "initials": "MF", "orcid": "0000-0003-2921-5892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33c2dafbb15e4ba4857a757eda516d56.json"}}, {"family": "Vergara Del Solar", "given": "Ana", "initials": "A", "orcid": "0000-0001-7823-3769", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6af89e09de6e455885fffab8c124d47b.json"}}, {"family": "Angeles", "given": "Sophia L", "initials": "SL", "orcid": "0000-0003-1407-2753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc7a158043034ea48799125447ef5dfd.json"}}, {"family": "Faircloth", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-2919-2814", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ac7f62100114af098aee4e7e914c5ef.json"}}, {"family": "Liu", "given": "Lu", "initials": "L", "orcid": "0000-0003-2101-4586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88b3fd92889a4da58f1f77857c4db6ff.json"}}, {"family": "Mwanda", "given": "Anita", "initials": "A", "orcid": "0000-0001-8161-0000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f796590cf01b494f80336fd93d14b87a.json"}}, {"family": "Sep\u00falveda Galeas", "given": "Mauricio", "initials": "M", "orcid": "0000-0002-0736-6596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a5aa9dfad67421fae144dc866e9f1e2.json"}}, {"family": "Simelane", "given": "Thandi", "initials": "T", "orcid": "0000-0001-9906-1820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8443cdc6041c4a7ba103d8413c810b78.json"}}, {"family": "Twamley", "given": "Katherine", "initials": "K", "orcid": "0000-0001-8701-7427", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a090cb6978b14bebb226e224a6347c1b.json"}}, {"family": "Darcy", "given": "Laura", "initials": "L", "orcid": "0000-0002-9383-0227", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ed200c452dc423981354cc103223c0c.json"}}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Int J Qual Stud Health Well-being", "issn": "1748-2631", "issn-l": null, "volume": "18", "issue": "1", "pages": "2251236"}, "abstract": "To illuminate the meaning of social relationships and health concerns as experienced by adolescents and young people during the COVID-19 pandemic.\r\n\r\nA longitudinal qualitative study was conducted. Data reported from 172 adolescents and young people aged 12-24 years in five countries; Chile, South Africa, Sweden, the United Kingdom and the United States collected from May 2020 to June 2021 were analysed via thematic analysis.\r\n\r\nAdolescents and young peoples' experiences of social relationships and health concerns were described in seven themes: Family proximity, conflicts and frustration; difficulties and challenges related to limited living space; peer relations and maintaining friendship in times of social distancing; the importance of school as a place for interaction; vulnerability, emotional distress and uncertainty about the future; health concerns and sense of caring for others; and worries and concerns related to financial hardship. These reports show that the changes to everyday life that were introduced by public responses to the pandemic generated feelings of loneliness, vulnerability, and emotional distress, as well as increased sense of togetherness with family.\r\n\r\nThe everyday lives of adolescents and young people were restricted and affected more by the consequences of the pandemic than by the COVID-19 virus. These experiences had various impacts on well-being and mental health, where some individuals felt more exposed and vulnerable to emotional distress and loneliness than others. Family and peer relationships could be protective and support a sense of togetherness and belonging. Hence, social relationships are important to provide emotional support. Support for adolescents and young people should be tailored accordingly around social and emotional concerns, to encourage health and well-being.", "doi": "10.1080/17482631.2023.2251236", "pmid": "37639471", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10464546"}], "notes": [], "created": "2023-10-05T08:26:01.693Z", "modified": "2023-10-06T04:43:05.249Z"}, {"entity": "publication", "iuid": "b5b0aec2627946a0b9e29efb73968cd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5b0aec2627946a0b9e29efb73968cd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5b0aec2627946a0b9e29efb73968cd0"}}, "title": "A survey of pharmacists' perception of the work environment and patient safety in community pharmacies during the COVID-19 pandemic.", "authors": [{"family": "Ljungberg Persson", "given": "C", "initials": "C"}, {"family": "Nord\u00e9n H\u00e4gg", "given": "A", "initials": "A"}, {"family": "S\u00f6derg\u00e5rd", "given": "B", "initials": "B"}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Explor Res Clin Soc Pharm", "issn": "2667-2766", "issn-l": null, "volume": "12", "issue": null, "pages": "100327"}, "abstract": "Community pharmacies have changed during the COVID-19 pandemic, and new routines have been introduced to address the needs of customers and staff and to reduce the risk of spreading infection. Burnout has been described among staff possibly due to a changed working climate. However, little research has focused on the pandemic's effect on patient safety in community pharmacies.\r\n\r\nTo examine pharmacists' perceptions of the impact of the COVID-19 pandemic on workload, working environment, and patient safety in community pharmacies.\r\n\r\nA survey was distributed to all Swedish community pharmacists, constituting a census study. Questions regarding the pharmacists' perception of the impact of the pandemic on workload, working environment, and patient safety were included. Respondents were asked to provide comments on their working situation. Quantitative results were analysed using descriptive statistics, and comments were analysed using qualitative content analysis.\r\n\r\nThe response rate was 41% (2034 responses). Most pharmacists (62%) considered the workload to be increased during the pandemic while work environment deteriorated (physical work environment was considered worse by 47% of respondents while psychosocial work environment was considered worse by 59%). Despite this, many respondents (55%) believed that patient safety was not affected. Neither having had COVID-19 nor being afraid of contracting it, influenced these perceptions in any substantial way. Findings were consistent regardless of education, professional role, number of years in community pharmacies, or special assignments in the pharmacies. According to the respondents, the communication within pharmacy companies during the pandemic was inadequate.\r\n\r\nThe impact of the pandemic on working conditions is in line with previous findings but the effect on patient safety needs further studies. The respondents felt the management had a limited understanding of the conditions during the pandemic, which stresses the importance of good and clear communication during a crisis.", "doi": "10.1016/j.rcsop.2023.100327", "pmid": "37780549", "labels": {"Category: Social Science & Humanities": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10534261"}, {"db": "pii", "key": "S2667-2766(23)00108-7"}], "notes": [], "created": "2023-11-01T13:33:04.942Z", "modified": "2023-11-02T07:10:43.155Z"}, {"entity": "publication", "iuid": "c816b72c2d304c2b8289761e8b6335bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c816b72c2d304c2b8289761e8b6335bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c816b72c2d304c2b8289761e8b6335bf"}}, "title": "\"Who is Anders Tegnell?\" Unanswered questions hamper COVID-19 vaccine uptake: A qualitative study among ethnic minorities in Sweden.", "authors": [{"family": "Herzig van Wees", "given": "Sibylle", "initials": "S"}, {"family": "St\u00e5lgren", "given": "Maria", "initials": "M"}, {"family": "Viberg", "given": "Nina", "initials": "N"}, {"family": "Puranen", "given": "Bi", "initials": "B"}, {"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM"}, {"family": "Larsson", "given": "Elin C", "initials": "EC"}], "type": "journal article", "published": "2023-11-30", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null, "volume": "41", "issue": "49", "pages": "7476-7481"}, "abstract": "Despite high COVID-19 vaccination coverage in many European countries, vaccination uptake has been lower among ethnic minorities, including in Sweden. This is in spite of the increased risk of contracting the virus and targeted efforts to vaccinate among first and second generation migrants. The aim of this study was to understand this dilemma by investigating ethnic minorities' perceptions and their experience of accessing the COVID-19 vaccine.\r\n\r\nThis is a qualitative study drawing on 18 semi-structured interviews with health volunteers working in ethnic minority communities and with participants from the two largest ethnic minorities in Sweden (Syria and Somalia). Deductive qualitative analysis was completed using the 3C model by WHO (Complacency, Confidence and Convenience).\r\n\r\nComplacency does not appear to be a barrier to intention to vaccinate. Participants are well aware of COVID-19 risk and the benefits of the vaccine. However, confidence in vaccine poses a barrier to uptake and there are a lot of questions and concerns about vaccine side effects, efficacy and related rumors. Confidence in health providers, particularly doctors is high but there was a sense of conflicting information. Accessing individually tailored health information and health providers is not convenient and a major reason for delaying vaccination or not vaccinating at all. Trust in peers, schools and faith-leaders is high and constitute pathways for effective health information sharing.\r\n\r\nEthnic minorities in Sweden are willing to get vaccinated against COVID-19. However, to increase vaccination uptake, access to individually tailored and face to face health information to answer questions about vaccine safety, efficacy, conflicting information and rumors is urgently required.", "doi": "10.1016/j.vaccine.2023.11.016", "pmid": "37953100", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null, "Funder: VR": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(23)01328-2"}], "notes": [], "created": "2023-12-04T07:17:21.272Z", "modified": "2023-12-04T07:45:25.006Z"}, {"entity": "publication", "iuid": "f10412528e554f6d8e9dc77aa8183e3e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f10412528e554f6d8e9dc77aa8183e3e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f10412528e554f6d8e9dc77aa8183e3e"}}, "title": "Vagus nerve SARS-CoV-2 infection and inflammatory reflex dysfunction: Is there a causal relationship?", "authors": [{"family": "Andersson", "given": "Ulf", "initials": "U", "orcid": "0000-0003-0316-3860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee9bbcb5111f446e99ff8b68c4027f5c.json"}}, {"family": "Tracey", "given": "Kevin J", "initials": "KJ"}], "type": "journal article", "published": "2023-11-29", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Autonomic dysfunction is a clinical hallmark of infection caused by SARS-CoV-2, but the underlying mechanisms are unknown. The vagus nerve inflammatory reflex is an important, well-characterized mechanism for the reflexive suppression of cytokine storm, and its experimental or clinical impairment facilitates the onset and progression of hyperinflammation. Recent pathological evidence from COVID-19 victims reveals viral infection and inflammation in the vagus nerve and associated nuclei in the medulla oblongata. Although it has been suggested that vagus nerve inflammation in these patients mediates dysregulated respiration, whether it also contributes to dysfunction of the vagus nerve inflammatory reflex has not been addressed. Because lethality and tissue injury in acute COVID-19 are characterized by cytokine storm, it is plausible to consider evidence that impairment of the inflammatory reflex may contribute to overproduction of cytokines and resultant hyperinflammatory pathogenesis. Accordingly, here the authors discuss the inflammatory reflex, the consequences of its dysfunction in COVID-19, and whether there are opportunities for therapeutic intervention.", "doi": "10.1111/joim.13746", "pmid": "38018736", "labels": {"Category: Health": null, "Type: Review": null}, "xrefs": [], "notes": [], "created": "2023-12-04T07:16:39.033Z", "modified": "2023-12-04T07:26:32.958Z"}, {"entity": "publication", "iuid": "6257590a79f347649a6d6751214d5f57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6257590a79f347649a6d6751214d5f57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6257590a79f347649a6d6751214d5f57"}}, "title": "SARS-CoV-2 variant-specific differences in inhibiting the effects of the PKR-activated integrated stress response.", "authors": [{"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Tynell", "given": "Janne", "initials": "J"}], "type": "journal article", "published": "2023-11-28", "journal": {"title": "Virus Res", "issn": "1872-7492", "issn-l": null, "volume": "339", "issue": null, "pages": "199271"}, "abstract": "The integrated stress response (ISR) is a eukaryotic cell pathway that triggers translational arrest and the formation of stress granules (SGs) in response to various stress signals, including those caused by viral infections. The SARS-CoV-2 nucleocapsid protein has been shown to disrupt SGs, but SARS-CoV-2 interactions with other components of the pathway remains poorly characterized. Here, we show that SARS-CoV-2 infection triggers the ISR through activation of the eIF2\u03b1-kinase PKR while inhibiting a variety of downstream effects. In line with previous studies, SG formation was efficiently inhibited and the induced eIF2\u03b1 phosphorylation only minimally contributed to the translational arrest observed in infected cells. Despite ISR activation and translational arrest, expression of the stress-responsive transcription factors ATF4 and CHOP was not induced in SARS-CoV-2 infected cells. Finally, we found variant-specific differences in the activation of the ISR between ancestral SARS-CoV-2 and the Delta and Omicron BA.1 variants in that Delta infection induced weaker PKR activation while Omicron infection induced higher levels of p-eIF2\u03b1, and greatly increased SG formation compared to the other variants. Our results suggest that different SARS-CoV-2 variants can affect normal cell functions differently, which can have an impact on pathogenesis and treatment strategies.", "doi": "10.1016/j.virusres.2023.199271", "pmid": "37979658", "labels": {"Funder: KAW/SciLifeLab": null, "Category: Other": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S0168-1702(23)00233-2"}], "notes": [], "created": "2023-12-04T07:17:29.224Z", "modified": "2023-12-04T07:54:51.371Z"}, {"entity": "publication", "iuid": "7e151092b98c4eee9afbb19889b3682e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e151092b98c4eee9afbb19889b3682e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e151092b98c4eee9afbb19889b3682e"}}, "title": "Clarity and adaptability of instructions preventing the spread of the COVID-19 virus and its association with individual and organisational factors regarding the psychosocial work environment: a cross-sectional study.", "authors": [{"family": "Hammar", "given": "Lena Marmst\u00e5l", "initials": "LM"}, {"family": "Alam", "given": "Moudud", "initials": "M"}, {"family": "Eklund", "given": "Caroline", "initials": "C"}, {"family": "Bostr\u00f6m", "given": "Anne-Marie", "initials": "A"}, {"family": "L\u00f6venmark", "given": "Annica", "initials": "A"}], "type": "journal article", "published": "2023-11-28", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "issn-l": null, "volume": "23", "issue": "1", "pages": "1312"}, "abstract": "In Sweden, older people in residential care had the highest mortality rates, followed by those who received home care, during the coronavirus disease 2019 (COVID-19) pandemic. Staff working in the care of older people assumed responsibility for preventing the spread of the virus despite lacking the prerequisites and training. This study aimed to investigate the psychosocial work environment during the COVID-19 pandemic among staff in the care of older people and examine the factors associated with staff's perceptions of the clarity of instructions and the ability to follow them.\r\n\r\nA cross-sectional study design was employed using a web survey. The staff's perceptions of their psychosocial environment were analysed using descriptive statistics. The association between organisational and individual factors, as well as the degree of clarity of the instructions and the staff's ability to follow them, were assessed using multivariate (ordinal) regression analysis.\r\n\r\nThe main findings show that perceptions of the clarity and adaptability of the instructions were primarily correlated with organisational factors, as higher responses (positive) for the subscales focusing on role clarity, support and encouragement in leadership at work were associated with the belief that the instructions were clear. Similarly, those indicating high job demands and high individual learning demands were less likely to report that the instructions were clear. Regarding adaptability, high scores for demands on learning and psychological demands were correlated with lower adaptability, while high scores for role clarity, encouraging leadership and social support, were associated with higher adaptability.\r\n\r\nHigh job demands and individual learning demands were demonstrated to decrease the staff's understanding and adoption of instructions. These findings are significant on an organisational level since the work environment must be prepared for potential future pandemics to promote quality improvement and generally increase patient safety and staff health.", "doi": "10.1186/s12913-023-10320-1", "pmid": "38017458", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10683104"}, {"db": "pii", "key": "10.1186/s12913-023-10320-1"}], "notes": [], "created": "2023-12-04T07:21:10.592Z", "modified": "2023-12-04T08:12:50.789Z"}, {"entity": "publication", "iuid": "dd0e2d52e4354c37a9a44d626353f722", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dd0e2d52e4354c37a9a44d626353f722.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dd0e2d52e4354c37a9a44d626353f722"}}, "title": "Associations between changes in habitual sleep duration and lower self-rated health among COVID-19 survivors: findings from a survey across 16 countries/regions.", "authors": [{"family": "Matsui", "given": "Kentaro", "initials": "K"}, {"family": "Chung", "given": "Frances", "initials": "F"}, {"family": "Bjelajac", "given": "Adrijana Koscec", "initials": "AK"}, {"family": "Merikanto", "given": "Ilona", "initials": "I"}, {"family": "Korman", "given": "Maria", "initials": "M"}, {"family": "Mota-Rolim", "given": "S\u00e9rgio", "initials": "S"}, {"family": "Cunha", "given": "Ana Suely", "initials": "AS"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Xue", "given": "Pei", "initials": "P"}, {"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "Espie", "given": "Colin A", "initials": "CA"}, {"family": "Landtblom", "given": "Anne-Marie", "initials": "A"}, {"family": "Penzel", "given": "Thomas", "initials": "T"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Hrubos-Str\u00f8m", "given": "Harald", "initials": "H"}, {"family": "Leger", "given": "Damien", "initials": "D"}, {"family": "Bolstad", "given": "Courtney J", "initials": "CJ"}, {"family": "Nadorff", "given": "Michael R", "initials": "MR"}, {"family": "Plazzi", "given": "Giuseppe", "initials": "G"}, {"family": "Reis", "given": "Catia", "initials": "C"}, {"family": "Chan", "given": "Ngan Yin", "initials": "NY"}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK"}, {"family": "Yordanova", "given": "Juliana", "initials": "J"}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "Inoue", "given": "Yuichi", "initials": "Y"}], "type": "journal article", "published": "2023-11-28", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "23", "issue": "1", "pages": "2352"}, "abstract": "Self-rated health (SRH) is widely recognized as a clinically significant predictor of subsequent mortality risk. Although COVID-19 may impair SRH, this relationship has not been extensively examined. The present study aimed to examine the correlation between habitual sleep duration, changes in sleep duration after infection, and SRH in subjects who have experienced SARS-CoV-2 infection.\r\n\r\nParticipants from 16 countries participated in the International COVID Sleep Study-II (ICOSS-II) online survey in 2021. A total of 10,794 of these participants were included in the analysis, including 1,509 COVID-19 individuals (who reported that they had tested positive for COVID-19). SRH was evaluated using a 0-100 linear visual analog scale. Habitual sleep durations of < 6 h and > 9 h were defined as short and long habitual sleep duration, respectively. Changes in habitual sleep duration after infection of \u2264 -2 h and \u2265 1 h were defined as decreased or increased, respectively.\r\n\r\nParticipants with COVID-19 had lower SRH scores than non-infected participants, and those with more severe COVID-19 had a tendency towards even lower SRH scores. In a multivariate regression analysis of participants who had experienced COVID-19, both decreased and increased habitual sleep duration after infection were significantly associated with lower SRH after controlling for sleep quality (\u03b2 = -0.056 and -0.058, respectively, both p < 0.05); however, associations between current short or long habitual sleep duration and SRH were negligible. Multinomial logistic regression analysis showed that decreased habitual sleep duration was significantly related to increased fatigue (odds ratio [OR] = 1.824, p < 0.01), shortness of breath (OR = 1.725, p < 0.05), diarrhea/nausea/vomiting (OR = 2.636, p < 0.01), and hallucinations (OR = 5.091, p < 0.05), while increased habitual sleep duration was significantly related to increased fatigue (OR = 1.900, p < 0.01).\r\n\r\nChanges in habitual sleep duration following SARS-CoV-2 infection were associated with lower SRH. Decreased or increased habitual sleep duration might have a bidirectional relation with post-COVID-19 symptoms. Further research is needed to better understand the mechanisms underlying these relationships for in order to improve SRH in individuals with COVID-19.", "doi": "10.1186/s12889-023-17258-3", "pmid": "38017498", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10683140"}, {"db": "pii", "key": "10.1186/s12889-023-17258-3"}], "notes": [], "created": "2023-12-04T07:16:41.555Z", "modified": "2023-12-04T07:27:52.983Z"}, {"entity": "publication", "iuid": "65a87ecf50ee42e98fa9d706431bdbc4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65a87ecf50ee42e98fa9d706431bdbc4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65a87ecf50ee42e98fa9d706431bdbc4"}}, "title": "Sociodemographic characteristics and COVID-19 testing rates: spatiotemporal patterns and impact of test accessibility in Sweden.", "authors": [{"family": "Kennedy", "given": "Beatrice", "initials": "B", "orcid": "0000-0002-0066-4814", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d3a346caa424c4dad653097b2518efb.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G"}, {"family": "Hammar", "given": "Ulf", "initials": "U"}, {"family": "Nguyen", "given": "Diem", "initials": "D"}, {"family": "Carrasquilla", "given": "Germ\u00e1n D", "initials": "GD"}, {"family": "van Zoest", "given": "Vera", "initials": "V"}, {"family": "Kristiansson", "given": "Robert S", "initials": "RS"}, {"family": "Fitipaldi", "given": "Hugo", "initials": "H", "orcid": "0000-0001-5352-2134", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3dc5e2fbac6748eaa733dc8ee1abdfa8.json"}}, {"family": "Dekkers", "given": "Koen F", "initials": "KF"}, {"family": "Daivadanam", "given": "Meena", "initials": "M"}, {"family": "Martinell", "given": "Mats", "initials": "M"}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J", "orcid": "0000-0003-1883-2000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e88fdca336ae41c891f0a46e2481b67f.json"}}, {"family": "Fall", "given": "Tove", "initials": "T"}], "type": "journal article", "published": "2023-11-27", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": null, "issue": null, "pages": null}, "abstract": "Diagnostic testing is essential for disease surveillance and test-trace-isolate efforts. We aimed to investigate if residential area sociodemographic characteristics and test accessibility were associated with Coronavirus Disease 2019 (COVID-19) testing rates.\r\n\r\nWe included 426 224 patient-initiated COVID-19 polymerase chain reaction tests from Uppsala County in Sweden from 24 June 2020 to 9 February 2022. Using Poisson regression analyses, we investigated if postal code area Care Need Index (CNI; median 1.0, IQR 0.8-1.4), a composite measure of sociodemographic factors used in Sweden to allocate primary healthcare resources, was associated with COVID-19 daily testing rates after adjustments for community transmission. We assessed if the distance to testing station influenced testing, and performed a difference-in-difference-analysis of a new testing station targeting a disadvantaged neighbourhood.\r\n\r\nWe observed that CNI, i.e. primary healthcare need, was negatively associated with COVID-19 testing rates in inhabitants 5-69 years. More pronounced differences were noted across younger age groups and in Uppsala City, with test rate ratios in children (5-14 years) ranging from 0.56 (95% CI 0.47-0.67) to 0.87 (95% CI 0.80-0.93) across three pandemic waves. Longer distance to the nearest testing station was linked to lower testing rates, e.g. every additional 10 km was associated with a 10-18% decrease in inhabitants 15-29 years in Uppsala County. The opening of the targeted testing station was associated with increased testing, including twice as high testing rates in individuals aged 70-105, supporting an intervention effect.\r\n\r\nEnsuring accessible testing across all residential areas constitutes a promising tool to decrease inequalities in testing.", "doi": "10.1093/eurpub/ckad209", "pmid": "38011903", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null, "Funder: Vinnova": null}, "xrefs": [{"db": "pii", "key": "7452814"}], "notes": [], "created": "2023-12-04T07:17:24.021Z", "modified": "2023-12-04T07:46:26.534Z"}, {"entity": "publication", "iuid": "4e95270ddbc5439b84402aa538a907f3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4e95270ddbc5439b84402aa538a907f3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4e95270ddbc5439b84402aa538a907f3"}}, "title": "Recognition of COVID-19 with occupational origin: a comparison between European countries.", "authors": [{"family": "Nys", "given": "Evelien", "initials": "E"}, {"family": "Pauwels", "given": "Sara", "initials": "S", "orcid": "0000-0002-4335-4867", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5584ae6a4b114978b169e81b9ca992a7.json"}}, {"family": "\u00c1d\u00e1m", "given": "Bal\u00e1zs", "initials": "B", "orcid": "0000-0002-9765-7142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6fd786870d81416facdace843c1d5c60.json"}}, {"family": "Amaro", "given": "Jo\u00e3o", "initials": "J"}, {"family": "Athanasiou", "given": "Athanasios", "initials": "A"}, {"family": "Bashkin", "given": "Osnat", "initials": "O"}, {"family": "Bric", "given": "Tatjana Kofol", "initials": "TK"}, {"family": "Bulat", "given": "Petar", "initials": "P"}, {"family": "Caglayan", "given": "Cigdem", "initials": "C"}, {"family": "Guseva Canu", "given": "Irina", "initials": "I", "orcid": "0000-0001-7059-8421", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef423b959b874a34b443c97c28b89f81.json"}}, {"family": "Cebanu", "given": "Serghei", "initials": "S"}, {"family": "Charbotel", "given": "Barbara", "initials": "B", "orcid": "0000-0001-8805-6225", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7e64698d8444fa089d8b56d87652a7c.json"}}, {"family": "Cirule", "given": "Jolanta", "initials": "J"}, {"family": "Curti", "given": "Stefania", "initials": "S", "orcid": "0000-0003-4343-8873", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a405bfa449cd4d3fbd2ec275bd75bd49.json"}}, {"family": "Davidovitch", "given": "Nadav", "initials": "N"}, {"family": "Dopelt", "given": "Keren", "initials": "K"}, {"family": "Fikfak", "given": "Metoda Dodic", "initials": "MD"}, {"family": "Frilander", "given": "Heikki", "initials": "H"}, {"family": "Gustavsson", "given": "Per", "initials": "P", "orcid": "0000-0003-2221-8599", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43820392bdde47898fac7dd85504a633.json"}}, {"family": "H\u00f6per", "given": "Anje Christina", "initials": "AC"}, {"family": "Kiran", "given": "Sibel", "initials": "S"}, {"family": "Kogevinas", "given": "Manolis", "initials": "M"}, {"family": "Kud\u00e1sz", "given": "Ferenc", "initials": "F"}, {"family": "Kolstad", "given": "Henrik A", "initials": "HA"}, {"family": "Lazarevic", "given": "Sanja Brekalo", "initials": "SB"}, {"family": "Macan", "given": "Jelena", "initials": "J"}, {"family": "Majery", "given": "Nicole", "initials": "N"}, {"family": "Marinaccio", "given": "Alessandro", "initials": "A", "orcid": "0000-0001-9068-2137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91786dfb5147420fb086859745b7f7ea.json"}}, {"family": "Mates", "given": "Dana", "initials": "D"}, {"family": "Mattioli", "given": "Stefano", "initials": "S"}, {"family": "McElvenny", "given": "Damien Martin", "initials": "DM", "orcid": "0000-0003-0953-8336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ffabe7c996ff4f47af509448b20dff49.json"}}, {"family": "Mediouni", "given": "Zakia", "initials": "Z"}, {"family": "Mehlum", "given": "Ingrid Sivesind", "initials": "IS"}, {"family": "Merisalu", "given": "Eda", "initials": "E"}, {"family": "Mijakoski", "given": "Dragan", "initials": "D"}, {"family": "Nena", "given": "Evangelia", "initials": "E"}, {"family": "Noone", "given": "Peter", "initials": "P"}, {"family": "Otelea", "given": "Marina Ruxandra", "initials": "MR"}, {"family": "Pelclova", "given": "Daniela", "initials": "D", "orcid": "0000-0002-0240-5146", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45346161b36c472b83dcb8c33c1e52af.json"}}, {"family": "Pranjic", "given": "Nurka", "initials": "N"}, {"family": "Rosso", "given": "Mark", "initials": "M"}, {"family": "Serra", "given": "Consol", "initials": "C", "orcid": "0000-0001-8337-8356", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83f31809b46f4f4687fa7b88cf0f8543.json"}}, {"family": "Rushton", "given": "Lesley", "initials": "L"}, {"family": "Sandal", "given": "Abdulsamet", "initials": "A", "orcid": "0000-0002-9718-7769", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2dabd0a1ac242139b3fcef9afecca71.json"}}, {"family": "Schernhammer", "given": "Eva S", "initials": "ES"}, {"family": "Stoleski", "given": "Sasho", "initials": "S"}, {"family": "Turner", "given": "Michelle C", "initials": "MC", "orcid": "0000-0002-6431-1997", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76a0a961eee94fa9a4086f3f33c5455d.json"}}, {"family": "van der Molen", "given": "Henk F", "initials": "HF", "orcid": "0000-0002-0719-2020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ff714768c1949e59db29c681e08ed0c.json"}}, {"family": "Varga", "given": "Marek", "initials": "M"}, {"family": "Walusiak-Skorupa", "given": "Jolanta", "initials": "J"}, {"family": "Straif", "given": "Kurt", "initials": "K", "orcid": "0000-0003-1402-2406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/add903f488514f53b504566e7b0d0d3c.json"}}, {"family": "Godderis", "given": "Lode", "initials": "L", "orcid": "0000-0003-4764-8835", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/639b8bdac78742e9aeebe5b33c6dfedb.json"}}], "type": "journal article", "published": "2023-11-23", "journal": {"title": "Occup Environ Med", "issn": "1470-7926", "issn-l": null, "volume": "80", "issue": "12", "pages": "694-701"}, "abstract": "This study aims to present an overview of the formal recognition of COVID-19 as occupational disease (OD) or injury (OI) across Europe.\r\n\r\nA COVID-19 questionnaire was designed by a task group within COST-funded OMEGA-NET and sent to occupational health experts of 37 countries in WHO European region, with a last update in April 2022.\r\n\r\nThe questionnaire was filled out by experts from 35 countries. There are large differences between national systems regarding the recognition of OD and OI: 40% of countries have a list system, 57% a mixed system and one country an open system. In most countries, COVID-19 can be recognised as an OD (57%). In four countries, COVID-19 can be recognised as OI (11%) and in seven countries as either OD or OI (20%). In two countries, there is no recognition possible to date. Thirty-two countries (91%) recognise COVID-19 as OD/OI among healthcare workers. Working in certain jobs is considered proof of occupational exposure in 25 countries, contact with a colleague with confirmed infection in 19 countries, and contact with clients with confirmed infection in 21 countries. In most countries (57%), a positive PCR test is considered proof of disease. The three most common compensation benefits for COVID-19 as OI/OD are disability pension, treatment and rehabilitation. Long COVID is included in 26 countries.\r\n\r\nCOVID-19 can be recognised as OD or OI in 94% of the European countries completing this survey, across different social security and embedded occupational health systems.", "doi": "10.1136/oemed-2022-108726", "pmid": "37984917", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "oemed-2022-108726"}], "notes": [], "created": "2023-12-04T07:17:31.732Z", "modified": "2023-12-04T07:55:46.621Z"}, {"entity": "publication", "iuid": "ade134ab911e43bc9acf2a03f66846ab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ade134ab911e43bc9acf2a03f66846ab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ade134ab911e43bc9acf2a03f66846ab"}}, "title": "The Characterization of CD8+ T-cell Responses in COVID-19.", "authors": [{"family": "Yang", "given": "Yuanting", "initials": "Y"}, {"family": "Miller", "given": "Heather", "initials": "H"}, {"family": "Byazrova", "given": "Maria G", "initials": "MG"}, {"family": "Cndotti", "given": "Fabio", "initials": "F"}, {"family": "Benlagha", "given": "Kamel", "initials": "K"}, {"family": "Camara", "given": "Niels Olsen Saraiva", "initials": "NOS"}, {"family": "Shi", "given": "Junming", "initials": "J"}, {"family": "Forsman", "given": "Huamei", "initials": "H"}, {"family": "Lee", "given": "Pamela", "initials": "P"}, {"family": "Yang", "given": "Lu", "initials": "L"}, {"family": "Filatov", "given": "Alexander", "initials": "A"}, {"family": "Zhai", "given": "Zhimin", "initials": "Z"}, {"family": "Liu", "given": "Chaohong", "initials": "C"}], "type": "journal article", "published": "2023-11-22", "journal": {"title": "Emerg Microbes Infect", "issn": "2222-1751", "issn-l": "2222-1751", "volume": null, "issue": null, "pages": "2287118"}, "abstract": "This review gives an overview of the protective role of CD8+ T cells in SARS-CoV-2 infection. The cross-reactive responses intermediated by CD8+ T cells in unexposed cohorts are described. Additionally, the relevance of resident CD8+ T cells in the upper and lower airway during infection is discussed, and CD8+ T-cell responses following vaccination, including recent worrisome breakthrough infections and variants of concerns (VOCs). Lastly, we explained the correlation between CD8+ T cells and COVID-19 severity. This review aids in a deeper comprehension of the association between CD8+ T cells and SARS-CoV-2 and broadens a vision for future exploration.", "doi": "10.1080/22221751.2023.2287118", "pmid": "37990907", "labels": {"Type: Review": null, "Category: Other": null, "Category: Serology": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-12-04T07:16:50.307Z", "modified": "2023-12-04T07:32:24.229Z"}, {"entity": "publication", "iuid": "3f3bbbd4969d4e8b8665452c64bb8997", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f3bbbd4969d4e8b8665452c64bb8997.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f3bbbd4969d4e8b8665452c64bb8997"}}, "title": "Covid-19 vaccine effectiveness against post-covid-19 condition among 589 722 individuals in Sweden: population based cohort study.", "authors": [{"family": "Lundberg-Morris", "given": "Lisa", "initials": "L", "orcid": "0000-0002-5920-3801", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54811b8c587d4fd89e10b46e7c7f6b81.json"}}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Xu", "given": "Yiyi", "initials": "Y"}, {"family": "Martikainen", "given": "Jari", "initials": "J"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Bygdell", "given": "Maria", "initials": "M", "orcid": "0000-0002-0737-8642", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8384a1c06034aff9aae842750462643.json"}}], "type": "journal article", "published": "2023-11-22", "journal": {"title": "BMJ", "issn": "1756-1833", "issn-l": null, "volume": "383", "issue": null, "pages": "e076990"}, "abstract": "To investigate the effectiveness of primary covid-19 vaccination (first two doses and first booster dose within the recommended schedule) against post-covid-19 condition (PCC).\r\n\r\nPopulation based cohort study.\r\n\r\nSwedish Covid-19 Investigation for Future Insights-a Population Epidemiology Approach using Register Linkage (SCIFI-PEARL) project, a register based cohort study in Sweden.\r\n\r\nAll adults (\u226518 years) with covid-19 first registered between 27 December 2020 and 9 February 2022 (n=589 722) in the two largest regions of Sweden. Individuals were followed from a first infection until death, emigration, vaccination, reinfection, a PCC diagnosis (ICD-10 diagnosis code U09.9), or end of follow-up (30 November 2022), whichever came first. Individuals who had received at least one dose of a covid-19 vaccine before infection were considered vaccinated.\r\n\r\nThe primary outcome was a clinical diagnosis of PCC. Vaccine effectiveness against PCC was estimated using Cox regressions adjusted for age, sex, comorbidities (diabetes and cardiovascular, respiratory, and psychiatric disease), number of healthcare contacts during 2019, socioeconomic factors, and dominant virus variant at time of infection.\r\n\r\nOf 299 692 vaccinated individuals with covid-19, 1201 (0.4%) had a diagnosis of PCC during follow-up, compared with 4118 (1.4%) of 290 030 unvaccinated individuals. Covid-19 vaccination with any number of doses before infection was associated with a reduced risk of PCC (adjusted hazard ratio 0.42, 95% confidence interval 0.38 to 0.46), with a vaccine effectiveness of 58%. Of the vaccinated individuals, 21 111 received one dose only, 205 650 received two doses, and 72 931 received three or more doses. Vaccine effectiveness against PCC for one dose, two doses, and three or more doses was 21%, 59%, and 73%, respectively.\r\n\r\nThe results of this study suggest a strong association between covid-19 vaccination before infection and reduced risk of receiving a diagnosis of PCC. The findings highlight the importance of primary vaccination against covid-19 to reduce the population burden of PCC.", "doi": "10.1136/bmj-2023-076990", "pmid": "37993131", "labels": {"Funder: KAW/SciLifeLab": null, "Category: Post-COVID": null, "Type: Journal article": null, "Funder: VR": null, "Category: Vaccines": null, "Funder: Forte": null}, "xrefs": [{"db": "pmc", "key": "PMC10666099"}], "notes": [], "created": "2023-12-04T07:17:01.634Z", "modified": "2023-12-04T07:38:49.241Z"}, {"entity": "publication", "iuid": "f2276bf4ab9d4c689dbd424dbc8dcb7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f2276bf4ab9d4c689dbd424dbc8dcb7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f2276bf4ab9d4c689dbd424dbc8dcb7a"}}, "title": "SARS-CoV-2 antibodies from children exhibit broad neutralization and belong to adult public clonotypes.", "authors": [{"family": "Wall", "given": "Steven C", "initials": "SC"}, {"family": "Suryadevara", "given": "Naveenchandra", "initials": "N"}, {"family": "Kim", "given": "Changil", "initials": "C"}, {"family": "Shiakolas", "given": "Andrea R", "initials": "AR"}, {"family": "Holt", "given": "Clinton M", "initials": "CM"}, {"family": "Irbe", "given": "Emma B", "initials": "EB"}, {"family": "Wasdin", "given": "Perry T", "initials": "PT"}, {"family": "Suresh", "given": "Yukthi P", "initials": "YP"}, {"family": "Binshtein", "given": "Elad", "initials": "E"}, {"family": "Chen", "given": "Elaine C", "initials": "EC"}, {"family": "Zost", "given": "Seth J", "initials": "SJ"}, {"family": "Canfield", "given": "Elizabeth", "initials": "E"}, {"family": "Crowe", "given": "James E", "initials": "JE"}, {"family": "Thompson-Arildsen", "given": "Mary Ann", "initials": "MA"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Carnahan", "given": "Robert H", "initials": "RH"}, {"family": "Georgiev", "given": "Ivelin S", "initials": "IS"}], "type": "journal article", "published": "2023-11-21", "journal": {"title": "Cell Rep Med", "issn": "2666-3791", "issn-l": "2666-3791", "volume": "4", "issue": "11", "pages": "101267"}, "abstract": "From the beginning of the COVID-19 pandemic, children have exhibited different susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, reinfection, and disease compared with adults. Motivated by the established significance of SARS-CoV-2-neutralizing antibodies in adults, here we characterize SARS-CoV-2-specific antibody repertoires in a young cohort of individuals aged from 5 months to 18 years old. Our results show that neutralizing antibodies in children possess similar genetic features compared to antibodies identified in adults, with multiple antibodies from children belonging to previously established public antibody clonotypes in adults. Notably, antibodies from children show potent neutralization of circulating SARS-CoV-2 variants that have cumulatively resulted in resistance to virtually all approved monoclonal antibody therapeutics. Our results show that children can rely on similar SARS-CoV-2 antibody neutralization mechanisms compared to adults and are an underutilized source for the discovery of effective antibody therapeutics to counteract the ever-evolving pandemic.", "doi": "10.1016/j.xcrm.2023.101267", "pmid": "37935199", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Serology": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S2666-3791(23)00444-5"}], "notes": [], "created": "2023-12-04T07:16:52.853Z", "modified": "2023-12-04T07:34:21.865Z"}, {"entity": "publication", "iuid": "795f95718b05487aa5917cb571b2c48b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/795f95718b05487aa5917cb571b2c48b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/795f95718b05487aa5917cb571b2c48b"}}, "title": "Prolonged gastrointestinal manifestations after recovery from COVID-19.", "authors": [{"family": "Elmunzer", "given": "B Joseph", "initials": "BJ"}, {"family": "Palsson", "given": "Olafur S", "initials": "OS"}, {"family": "Forbes", "given": "Nauzer", "initials": "N"}, {"family": "Zakaria", "given": "Ali", "initials": "A"}, {"family": "Davis", "given": "Christian", "initials": "C"}, {"family": "Canakis", "given": "Andrew", "initials": "A"}, {"family": "Qayed", "given": "Emad", "initials": "E"}, {"family": "Bick", "given": "Benjamin", "initials": "B"}, {"family": "Pawa", "given": "Swati", "initials": "S"}, {"family": "Tierney", "given": "William M", "initials": "WM"}, {"family": "McLeod", "given": "Caroline G", "initials": "CG"}, {"family": "Taylor", "given": "Jason", "initials": "J"}, {"family": "Patel", "given": "Harsh", "initials": "H"}, {"family": "Mendelsohn", "given": "Robin B", "initials": "RB"}, {"family": "Bala", "given": "Gokul", "initials": "G"}, {"family": "Sloan", "given": "Ian", "initials": "I"}, {"family": "Merchant", "given": "Ambreen A", "initials": "AA"}, {"family": "Smith", "given": "Zachary L", "initials": "ZL"}, {"family": "Sendzischew Shane", "given": "Morgan A", "initials": "MA"}, {"family": "Aroniadis", "given": "Olga C", "initials": "OC"}, {"family": "Ordiah", "given": "Collins O", "initials": "CO"}, {"family": "Ruddy", "given": "Johannah M", "initials": "JM"}, {"family": "Simren", "given": "Magnus", "initials": "M"}, {"family": "Tack", "given": "Jan", "initials": "J"}, {"family": "Drossman", "given": "Douglas", "initials": "D"}, {"family": "Rome Foundation Research Institute", "given": "", "initials": ""}, {"family": "North American Alliance for the Study of Digestive Manifestations of COVID-19", "given": "", "initials": ""}], "type": "journal article", "published": "2023-11-21", "journal": {"title": "Clin Gastroenterol Hepatol", "issn": "1542-7714", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Acute enteric infections are well known to result in long-term gastrointestinal disorders. While COVID-19 is principally a respiratory illness, it demonstrates significant gastrointestinal tropism, possibly predisposing to prolonged gut manifestations. We aimed to examine the long-term gastrointestinal impact of hospitalization with COVID-19.\r\n\r\nNested within a large-scale observational cohort study of patients hospitalized with COVID-19 across North America, we performed a follow-up survey of 530 survivors 12-18 months later to assess for persistent GI symptoms and their severity, and for the development of disorders of gut-brain interaction (DGBIs). Eligible patients were identified at the study site level and surveyed electronically. The survey instrument included the Rome IV Diagnostic Questionnaire for Disorders of Gut-Brain Interaction, a rating scale of 24 COVID-related symptoms, the Gastrointestinal Symptoms Rating Scale (GSRS), and the Impact of Events-Revised (IES-R) trauma symptom questionnaire (a measure of post-traumatic stress associated with the illness experience). A regression analysis was performed to explore the factors associated with GI symptom severity at follow-up.\r\n\r\nOf the 530 invited patients, 116 responded (52.6% females; mean age 55.2 years), and 73 of those (60.3%) met criteria for one or more Rome IV DGBI at follow-up, higher than the prevalence in the US general population (p<0.0001). Among patients who experienced COVID-related GI symptoms during the index hospitalization (abdominal pain, nausea, vomiting, or diarrhea), 42.1% retained at least one of these symptoms at follow up; in comparison, 89.8% of respondents retained any (GI or non-GI) COVID-related symptom. The number of moderate or severe GI symptoms experienced during the initial COVID-19 illness by self-report correlated with the development of DGBI and severity of GI symptoms at follow-up. Post-traumatic stress disorder (IES-R score > 33) related to the COVID-19 illness experience was identified in 41.4% of respondents and those individuals had higher DGBI prevalence and GI symptom severity. Regression analysis revealed that higher psychological trauma score (IES-R) was the strongest predictor of GI symptom severity at follow-up.\r\n\r\nIn this follow-up survey of patients 12-18 months after hospitalization with COVID-19, there was a high prevalence of DGBIs and persistent GI symptoms. Prolonged gastrointestinal manifestations were associated with the severity of GI symptoms during hospitalization and with the degree of psychological trauma related to the illness experience.", "doi": "10.1016/j.cgh.2023.11.009", "pmid": "37995983", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1542-3565(23)00947-3"}], "notes": [], "created": "2023-12-04T07:21:15.275Z", "modified": "2023-12-04T08:15:07.362Z"}, {"entity": "publication", "iuid": "ca03b049d5bf4fcfa35160f838170ee7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ca03b049d5bf4fcfa35160f838170ee7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ca03b049d5bf4fcfa35160f838170ee7"}}, "title": "Polymethoxyflavone from Citrus depressa as an inhibitor against various variants of SARS-CoV-2 spike protein.", "authors": [{"family": "Liu", "given": "Ta-Wei", "initials": "T"}, {"family": "Hsu", "given": "Su-Jung", "initials": "S"}, {"family": "Hsieh", "given": "Yves S Y", "initials": "YSY"}, {"family": "Liu", "given": "Hui-Kang", "initials": "H"}, {"family": "Lee", "given": "Ching-Kuo", "initials": "C"}], "type": "journal article", "published": "2023-11-21", "journal": {"title": "J Ethnopharmacol", "issn": "1872-7573", "issn-l": null, "volume": "320", "issue": null, "pages": "117412"}, "abstract": "In traditional Taiwanese medicine, Citrus depressa Hayata serves as the raw material of Chen-Pi which has been widely used to treat respiratory ailments. Scientific investigations have validated the attributes of C. depressa, elucidating its valuable properties, including antioxidative, anti-inflammatory, anticancer, neuroprotion, hepatoprotection, and hypolipidemic effects.\r\n\r\nThis study aims to isolate a universal inhibitor of the SARS-CoV-2 spike protein from C. depressa and confirm the mechanism by which these inhibitors disrupt the binding of the spike protein to hACE2.\r\n\r\nThe whole fruit of C. depressa was subjected to ethanol extraction, following by partitioning to obtain water, butanol, and ethyl acetate fractions. To identify the inhibitory components in citrus fruits, we performed both the SPR assay and the SARS-CoV-2 pseudo-virus assays. Subsequently, we employed a bioassay-guided approach to efficiently isolate and characterize the bioactive constituents that hindered the interaction between the SARS-CoV-2 spike protein and hACE2, using a combination of MPLC and Semi-preparative HPLC for compound isolation. ELISA based spike protein binding assay evaluate the inhibitory activities of the extract and potential constituents against multiple spike protein variants. To further shed light on the inhibitory mechanism, candidate inhibitors were validated through the SPR assay and molecular docking.\r\n\r\nThe crude extract and ethyl acetate layer derived from C. depressa showed significant inhibitory activity on SARS-CoV-2 Omicron BA.4/5, with IC50 of 77.4 \u03bcg/mL and 100 \u03bcg/mL, respectively. Ten potential compounds from C. depressa have been identified with inhibitory activity against various SARS-CoV-2 spike proteins. 2'-hydroxy-4,4',5',6'-tetramethoxychalcone (Cd3) and 5-hydroxy-3',4',6,7,8-pentamethoxyflavone (Cd8) also showed good inhibitory activity to the spike protein, with KD of 0.79 \u03bcM and 37.3 nM, respectively. These findings are in line with prior study, indicating Cd3 and Cd8 can bind to key amino acid residue, disrupting the formation of the spike protein and h-ACE2 complex.\r\n\r\nThis study presents the initial evidence showcasing the inhibitory effect of polymethoxyflavones (PMFs) on the spike protein of SARS-CoV-2. Moreover, the inhibitory activity of C. depressa extracts indicates their potential to prevent infections of different SARS-CoV-2 variants.", "doi": "10.1016/j.jep.2023.117412", "pmid": "37995824", "labels": {"Category: Drug Discovery": null, "Category: Proteins": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S0378-8741(23)01282-5"}], "notes": [], "created": "2023-12-04T07:21:55.540Z", "modified": "2023-12-08T06:02:29.142Z"}, {"entity": "publication", "iuid": "82afc996dbe44aef814dbdedc1c1df0f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82afc996dbe44aef814dbdedc1c1df0f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82afc996dbe44aef814dbdedc1c1df0f"}}, "title": "Social interactions and COVID-19 vaccine hesitancy: Evidence from a full population study in Sweden.", "authors": [{"family": "Klaesson", "given": "Johan", "initials": "J", "orcid": "0000-0001-8752-0428", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb5eec5c485441fca0bc9eccd9bda3c2.json"}}, {"family": "Lobo", "given": "Jos\u00e9", "initials": "J"}, {"family": "Mellander", "given": "Charlotta", "initials": "C"}], "type": "journal article", "published": "2023-11-20", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "11", "pages": "e0289309"}, "abstract": "We investigate whether an individual's information milieu-an individual's residential neighborhood and co-workers-affects the decision to get a COVID-19 vaccine. The decision to accept or refuse a vaccine is intensely personal and involves the processing of information about phenomena likely to be unfamiliar to most individuals. One can thus expect an interplay between an individual's level of education and skills and the information processing of others whom with whom she can interact and whose decision she can probe and observe. Using individual-level data for adults in Sweden, we can identify the proportion of an individual's neighborhood and workplace who are unvaccinated as indicators of possible peer effects. We find that individuals with low levels of educational attainment and occupational skills are more likely to be unvaccinated when exposed to other unvaccinated individuals at work and in the residential neighborhood. The peer effects in each of these information milieus further increases the likelihood of not getting vaccinated-with the two acting as information channels that reinforce one another.", "doi": "10.1371/journal.pone.0289309", "pmid": "37983227", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10659190"}, {"db": "pii", "key": "PONE-D-23-06735"}], "notes": [], "created": "2023-12-04T07:21:42.542Z", "modified": "2023-12-07T12:41:06.815Z"}, {"entity": "publication", "iuid": "ac222a9bcfde4957a35b6468f9650133", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac222a9bcfde4957a35b6468f9650133.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac222a9bcfde4957a35b6468f9650133"}}, "title": "Development of a proteomic signature associated with severe disease for patients with COVID-19 using data from 5 multicenter, randomized, controlled, and prospective studies.", "authors": [{"family": "Castro-Pearson", "given": "Sandra", "initials": "S"}, {"family": "Samorodnitsky", "given": "Sarah", "initials": "S"}, {"family": "Yang", "given": "Kaifeng", "initials": "K"}, {"family": "Lotfi-Emran", "given": "Sahar", "initials": "S"}, {"family": "Ingraham", "given": "Nicholas E", "initials": "NE"}, {"family": "Bramante", "given": "Carolyn", "initials": "C"}, {"family": "Jones", "given": "Emma K", "initials": "EK"}, {"family": "Greising", "given": "Sarah", "initials": "S"}, {"family": "Yu", "given": "Meng", "initials": "M"}, {"family": "Steffen", "given": "Brian", "initials": "B"}, {"family": "Svensson", "given": "Julia", "initials": "J"}, {"family": "\u00c5hlberg", "given": "Eric", "initials": "E"}, {"family": "\u00d6sterberg", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Wacker", "given": "David", "initials": "D"}, {"family": "Guan", "given": "Weihua", "initials": "W"}, {"family": "Puskarich", "given": "Michael", "initials": "M"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Lusczek", "given": "Elizabeth", "initials": "E"}, {"family": "Safo", "given": "Sandra E", "initials": "SE"}, {"family": "Tignanelli", "given": "Christopher J", "initials": "CJ"}], "type": "multicenter study", "published": "2023-11-20", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "20315"}, "abstract": "Significant progress has been made in preventing severe COVID-19 disease through the development of vaccines. However, we still lack a validated baseline predictive biologic signature for the development of more severe disease in both outpatients and inpatients infected with SARS-CoV-2. The objective of this study was to develop and externally validate, via 5 international outpatient and inpatient trials and/or prospective cohort studies, a novel baseline proteomic signature, which predicts the development of moderate or severe (vs mild) disease in patients with COVID-19 from a proteomic analysis of 7000 + proteins. The secondary objective was exploratory, to identify (1) individual baseline protein levels and/or (2) protein level changes within the first 2 weeks of acute infection that are associated with the development of moderate/severe (vs mild) disease. For model development, samples collected from 2 randomized controlled trials were used. Plasma was isolated and the SomaLogic SomaScan platform was used to characterize protein levels for 7301 proteins of interest for all studies. We dichotomized 113 patients as having mild or moderate/severe COVID-19 disease. An elastic net approach was used to develop a predictive proteomic signature. For validation, we applied our signature to data from three independent prospective biomarker studies. We found 4110 proteins measured at baseline that significantly differed between patients with mild COVID-19 and those with moderate/severe COVID-19 after adjusting for multiple hypothesis testing. Baseline protein expression was associated with predicted disease severity with an error rate of 4.7% (AUC = 0.964). We also found that five proteins (Afamin, I-309, NKG2A, PRS57, LIPK) and patient age serve as a signature that separates patients with mild COVID-19 and patients with moderate/severe COVID-19 with an error rate of 1.77% (AUC = 0.9804). This panel was validated using data from 3 external studies with AUCs of 0.764 (Harvard University), 0.696 (University of Colorado), and 0.893 (Karolinska Institutet). In this study we developed and externally validated a baseline COVID-19 proteomic signature associated with disease severity for potential use in both outpatients and inpatients with COVID-19.", "doi": "10.1038/s41598-023-46343-1", "pmid": "37985892", "labels": {"Category: Proteins": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10661735"}, {"db": "pii", "key": "10.1038/s41598-023-46343-1"}], "notes": [], "created": "2023-12-04T07:16:47.812Z", "modified": "2023-12-04T07:30:57.252Z"}, {"entity": "publication", "iuid": "189748c2c3a240e997c9b40a1259268f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/189748c2c3a240e997c9b40a1259268f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/189748c2c3a240e997c9b40a1259268f"}}, "title": "Psychological Health Among Older Adults During and After Quarantine: A Multi-Method Study.", "authors": [{"family": "Durante", "given": "Angela", "initials": "A"}, {"family": "Klompstra", "given": "Leonie", "initials": "L"}, {"family": "Cez\u00f3n-Serrano", "given": "Natalia", "initials": "N", "orcid": "0000-0002-9084-2089", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d45e4252ece4303b70f84036535f93b.json"}}, {"family": "Deka", "given": "Pallav", "initials": "P", "orcid": "0000-0002-3648-9843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d7d30bb4ad843f5a2d9e667df4edaa2.json"}}, {"family": "Arnal-G\u00f3mez", "given": "Anna", "initials": "A"}, {"family": "Querol-Giner", "given": "Felipe", "initials": "F"}, {"family": "Marques-Sule", "given": "Elena", "initials": "E"}], "type": "journal article", "published": "2023-11-19", "journal": {"title": "West J Nurs Res", "issn": "1552-8456", "issn-l": null, "volume": null, "issue": null, "pages": "1939459231214603"}, "abstract": "Depression among older adults is a growing problem. With aging being a risk factor for COVID-19 infection, depression in this population may have been exacerbated. This study aimed to describe experiences and changes in depressive symptoms and well-being of older adults during and after the COVID-19 first wave in Spain.\r\n\r\nThe study used a multi-method design. Participants self-reported depressive symptoms (Geriatric Depression Scale) and well-being (Cantril Ladder of Life). Participants were asked about changes in depressive symptoms or well-being during quarantine. If a change was perceived, they were asked to describe the change. In addition, the Patient Global Impression of Change scale was used. Both quantitative and qualitative analyses were performed on the data.\r\n\r\n111 participants (mean age: 71\u00b15 years; 76% women) completed the study. Sixty-three percent reported mild and 2% reported major depressive symptoms. Nearly half (47.7%) reported changes in depressive symptoms during the lockdown. While 37% reported feeling better during the lockdown, about 11% reported depressive symptoms were worse now compared with during the lockdown. 60% reported worsening well-being during the quarantining period. The qualitative analysis revealed 2 main themes: (1) psychological discomfort (mood deflection, fear/worries, and boredom/inactivity) and (2) social issues (inability to go out, missing family members and others).\r\n\r\nWorsening depressive symptoms and lowering of well-being were noticed in this sample of older adults during and post-COVID lockdowns. Evaluation of mental health in the primary care setting and providing referrals for mental health services is essential for older adults who experienced COVID-19-related lockdowns.", "doi": "10.1177/01939459231214603", "pmid": "37981724", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-12-04T07:21:17.536Z", "modified": "2023-12-04T08:16:11.076Z"}, {"entity": "publication", "iuid": "25a87e142081426496b150b3315b04dc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/25a87e142081426496b150b3315b04dc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/25a87e142081426496b150b3315b04dc"}}, "title": "Dysregulations in hemostasis, metabolism, immune response, and angiogenesis in post-acute COVID-19 syndrome with and without postural orthostatic tachycardia syndrome: a multi-omic profiling study.", "authors": [{"family": "Mahdi", "given": "Ali", "initials": "A"}, {"family": "Zhao", "given": "Allan", "initials": "A"}, {"family": "Fredengren", "given": "Emelie", "initials": "E"}, {"family": "Fedorowski", "given": "Artur", "initials": "A"}, {"family": "Braunschweig", "given": "Frieder", "initials": "F"}, {"family": "Nygren-Bonnier", "given": "Malin", "initials": "M"}, {"family": "Runold", "given": "Michael", "initials": "M"}, {"family": "Bruchfeld", "given": "Judith", "initials": "J"}, {"family": "Nickander", "given": "Jannike", "initials": "J"}, {"family": "Deng", "given": "Qiaolin", "initials": "Q"}, {"family": "Checa", "given": "Antonio", "initials": "A"}, {"family": "Desta", "given": "Liyew", "initials": "L"}, {"family": "Pernow", "given": "John", "initials": "J"}, {"family": "St\u00e5hlberg", "given": "Marcus", "initials": "M"}], "type": "journal article", "published": "2023-11-19", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "20230"}, "abstract": "Post-acute COVID-19 (PACS) are associated with cardiovascular dysfunction, especially postural orthostatic tachycardia syndrome (POTS). Patients with PACS, both in the absence or presence of POTS, exhibit a wide range of persisting symptoms long after the acute infection. Some of these symptoms may stem from alterations in cardiovascular homeostasis, but the exact mechanisms are poorly understood. The aim of this study was to provide a broad molecular characterization of patients with PACS with (PACS + POTS) and without (PACS-POTS) POTS compared to healthy subjects, including a broad proteomic characterization with a focus on plasma cardiometabolic proteins, quantification of cytokines/chemokines and determination of plasma sphingolipid levels. Twenty-one healthy subjects without a prior COVID-19 infection (mean age 43 years, 95% females), 20 non-hospitalized patients with PACS + POTS (mean age 39 years, 95% females) and 22 non-hospitalized patients with PACS-POTS (mean age 44 years, 100% females) were studied. PACS patients were non-hospitalized and recruited \u224818 months after the acute infection. Cardiometabolic proteomic analyses revealed a dysregulation of \u2248200 out of 700 analyzed proteins in both PACS groups vs. healthy subjects with the majority (> 90%) being upregulated. There was a large overlap (> 90%) with no major differences between the PACS groups. Gene ontology enrichment analysis revealed alterations in hemostasis/coagulation, metabolism, immune responses, and angiogenesis in PACS vs. healthy controls. Furthermore, 11 out of 33 cytokines/chemokines were significantly upregulated both in PACS + POTS and PACS-POTS vs. healthy controls and none of the cytokines were downregulated. There were no differences in between the PACS groups in the cytokine levels. Lastly, 16 and 19 out of 88 sphingolipids were significantly dysregulated in PACS + POTS and PACS-POTS, respectively, compared to controls with no differences between the groups. Collectively, these observations suggest a clear and distinct dysregulation in the proteome, cytokines/chemokines, and sphingolipid levels in PACS patients compared to healthy subjects without any clear signature associated with POTS. This enhances our understanding and might pave the way for future experimental and clinical investigations to elucidate and/or target resolution of inflammation and micro-clots and restore the hemostasis and immunity in PACS.", "doi": "10.1038/s41598-023-47539-1", "pmid": "37981644", "labels": {"Funder: Hj\u00e4rt-Lungfonden": null, "Category: Post-COVID": null, "Type: Journal article": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC10658082"}, {"db": "pii", "key": "10.1038/s41598-023-47539-1"}], "notes": [], "created": "2023-12-04T07:21:22.348Z", "modified": "2023-12-04T08:18:40.778Z"}, {"entity": "publication", "iuid": "e13452ceac9d470884e5369e5abbc29e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e13452ceac9d470884e5369e5abbc29e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e13452ceac9d470884e5369e5abbc29e"}}, "title": "A Systematic Review of Assessment Methods for Seafarers' Mental Health and Well-Being During the COVID-19 Pandemic.", "authors": [{"family": "Carrera-Arce", "given": "Maria", "initials": "M", "orcid": "0000-0001-9644-0315", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/907636563bf546f29a54f1afadd02f6f.json"}}, {"family": "Baumler", "given": "Raphael", "initials": "R"}, {"family": "Hollander", "given": "Johan", "initials": "J"}], "type": "systematic review", "published": "2023-11-17", "journal": {"title": "Inquiry", "issn": "1945-7243", "issn-l": null, "volume": "60", "issue": null, "pages": "469580231212218"}, "abstract": "Seafarers spend more time at sea than on land, which makes them a hard-to-reach community. Since their mental health and well-being is usually addressed from a land-based perspective, dedicated and validated methods incorporating maritime specificities are lacking. During the COVID-19 pandemic, research into seafarers' mental health and well-being flourished. However, a systematic review of the literature to assess the type and appropriateness of assessment methods pertaining to the mental health and well-being of seafarers has yet to be undertaken. This study reviews 5 databases (ERIC, Scopus, PubMed, Google Scholar and EBSCO) to assess the methods used to examine seafarers' mental health and well-being during the pandemic. Peer-reviewed literature alongside grey literature that applied quantitative or qualitative instruments to measure seafarers' mental health and/or well-being, published in English between March 2020 and February 2023, was eligible for the review. Studies from all geographic regions and regardless of nationality, rank and ship type of the subjects were explored. Database searches produced 272 records. Five additional records were identified via other methods. We identified 27 studies suitable for review, including 24 published in peer-reviewed scientific journals and 3 reports and surveys produced by the industry or welfare organizations. Assessment methods used to measure seafarers' mental health and well-being vary significantly in the literature. The frequent use of ad hoc questionnaires limits the possibility to replicate and compare the studies due to various inconsistencies. Furthermore, several validation and reliability measures needed more solidity when applied to the seafaring population. Such inadequate measuring and a mix of assessment methods impacted the comparison of results and might inflate the risks of underreporting or overstating mental complaints.", "doi": "10.1177/00469580231212218", "pmid": "37970799", "labels": {"Type: Review": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10655656"}], "notes": [], "created": "2023-12-04T07:22:19.168Z", "modified": "2023-12-08T06:12:38.272Z"}, {"entity": "publication", "iuid": "db7b8628df2a4ce9b97efbf5f92c43ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db7b8628df2a4ce9b97efbf5f92c43ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db7b8628df2a4ce9b97efbf5f92c43ae"}}, "title": "The mortality of COVID-19 in CML patients from 2020 until 2022: results from the EPICOVIDEHA survey.", "authors": [{"family": "El-Ashwah", "given": "Shaimaa", "initials": "S", "orcid": "0000-0003-2210-1534", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46dc0125ae354da09dddd0ffd083d199.json"}}, {"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J", "orcid": "0000-0002-6766-8297", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dea501020d2042ad83d1b024987792f4.json"}}, {"family": "Bilgin", "given": "Yavuz M", "initials": "YM", "orcid": "0000-0002-3783-3407", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c2318f4fc8345eda915937937f5b286.json"}}, {"family": "Itri", "given": "Federico", "initials": "F", "orcid": "0000-0002-3532-5281", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98feda63fd134739ab222629acdc3e46.json"}}, {"family": "\u017d\u00e1k", "given": "Pavel", "initials": "P", "orcid": "0000-0003-4465-5343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/575505da6a594afd909f7d23ee161067.json"}}, {"family": "Weinbergerov\u00e1", "given": "Barbora", "initials": "B", "orcid": "0000-0001-6460-2471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7ef50b8f8dc457ab2badd8481b3fa86.json"}}, {"family": "Verga", "given": "Luisa", "initials": "L", "orcid": "0000-0002-0868-3358", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3cf04033efd8444ea8c1e402612c441f.json"}}, {"family": "Omrani", "given": "Ali S", "initials": "AS", "orcid": "0000-0001-5309-6358", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/388bb06427c140a6b9a7d38484cda5fb.json"}}, {"family": "Silva", "given": "Maria Gomes da", "initials": "MGd", "orcid": "0000-0002-6993-2450", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75ea48d40e3647f189db6f726b4819bc.json"}}, {"family": "Szotkowski", "given": "Tom\u00e1\u0161", "initials": "T"}, {"family": "Marchetti", "given": "Monia", "initials": "M", "orcid": "0000-0001-7615-0572", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2fd4079badec41a7a7215d9b8fc37fb4.json"}}, {"family": "Buquicchio", "given": "Caterina", "initials": "C", "orcid": "0000-0002-3683-5953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d69fdacc414f4db28f00532bf69f9ce4.json"}}, {"family": "Nucci", "given": "Marcio", "initials": "M", "orcid": "0000-0003-4867-0014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/abfb43328b9e49f5bb8a68af1dea23a9.json"}}, {"family": "Sch\u00f6nlein", "given": "Martin", "initials": "M", "orcid": "0000-0002-1010-0975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bc914f4fd004b8695f47c8ef5373941.json"}}, {"family": "Farina", "given": "Francesca", "initials": "F", "orcid": "0000-0002-5124-6970", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06ead8985bd241ee814a94a6186bb898.json"}}, {"family": "Besson", "given": "Caroline", "initials": "C", "orcid": "0000-0003-4364-7173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adc322a60efe4963a3ff76aa00c885d6.json"}}, {"family": "Prezioso", "given": "Lucia", "initials": "L", "orcid": "0000-0003-1660-4960", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15e034f631c941d6877180153dc19b7c.json"}}, {"family": "Nizamuddin", "given": "Summiya", "initials": "S"}, {"family": "D\u00e1vila-Valls", "given": "Julio", "initials": "J", "orcid": "0000-0002-5185-2073", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1fd527ad06f047ca91f40cb7c5691694.json"}}, {"family": "Mart\u00edn-P\u00e9rez", "given": "Sonia", "initials": "S", "orcid": "0000-0001-5809-7165", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e975989b675849e0a41dcb4bae7d1339.json"}}, {"family": "Bonuomo", "given": "Valentina", "initials": "V", "orcid": "0000-0001-6491-8337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/71cfcc19d793475898e9a4e94d9ba5ba.json"}}, {"family": "Van Doesum", "given": "Jaap", "initials": "J", "orcid": "0000-0003-0214-3219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49152311cb004139904554d1c096c05c.json"}}, {"family": "Tisi", "given": "Maria Chiara", "initials": "MC", "orcid": "0000-0001-8231-6700", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/acb0b7f77d2d4c5ca66e2e653261b701.json"}}, {"family": "Passamonti", "given": "Francesco", "initials": "F", "orcid": "0000-0001-8068-5289", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c53c1d6fb8ef4181b5eb4bcb72d22d2d.json"}}, {"family": "M\u00e9ndez", "given": "Gustavo-Adolfo", "initials": "G"}, {"family": "Meers", "given": "Stef", "initials": "S", "orcid": "0000-0003-1754-2175", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a321aeb4b5e4d62a879d16eb31eefbd.json"}}, {"family": "Maertens", "given": "Johan", "initials": "J", "orcid": "0000-0003-4257-5980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4701b45871ba4030a2c57c01edcbf6e0.json"}}, {"family": "L\u00f3pez-Garc\u00eda", "given": "Alberto", "initials": "A", "orcid": "0000-0002-5354-5261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c785356a67e4cbb9835fe9ce04a6153.json"}}, {"family": "Glenth\u00f8j", "given": "Andreas", "initials": "A", "orcid": "0000-0003-2082-0738", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48786cc14bd5452badb25e0a8bf4b099.json"}}, {"family": "Bonnani", "given": "Matteo", "initials": "M", "orcid": "0000-0003-1775-6333", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81694822ac4d4074bfabe757d03f5f9e.json"}}, {"family": "Rinaldi", "given": "Ikhwan", "initials": "I"}, {"family": "Ormazabal-V\u00e9lez", "given": "Irati", "initials": "I", "orcid": "0000-0003-1141-5546", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cb942fd78d248f2b6de7be6befb844c.json"}}, {"family": "Labrador", "given": "Jorge", "initials": "J", "orcid": "0000-0002-3696-0287", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9eab3a75d0294b74a6f9aa9eeb0b32f4.json"}}, {"family": "Kulasekararaj", "given": "Austin", "initials": "A", "orcid": "0000-0003-3180-3570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd4719161efc4d939fe6f4832430a1bc.json"}}, {"family": "Espigado", "given": "Ildefonso", "initials": "I", "orcid": "0000-0002-4043-6613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40c943f7cd0e40998a4a1ae519a39e48.json"}}, {"family": "Demirkan", "given": "Fatih", "initials": "F", "orcid": "0000-0002-1172-8668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20a94af0626a4365bed5bf8235b9ed66.json"}}, {"family": "De Jonge", "given": "Nick", "initials": "N", "orcid": "0000-0002-9901-0887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b6aa76fb242f46839bc0f606613ee4c5.json"}}, {"family": "Collins", "given": "Graham P", "initials": "GP"}, {"family": "Calbacho", "given": "Maria", "initials": "M", "orcid": "0000-0001-8106-4863", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/301b59d7b5074ace866319c0210d60ac.json"}}, {"family": "Blennow", "given": "Ola", "initials": "O", "orcid": "0000-0002-7167-7882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2318c3973e66443aa14fceca0908d127.json"}}, {"family": "Al-Khabori", "given": "Murtadha", "initials": "M", "orcid": "0000-0002-2937-8838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/297d673b7b5f49dbb77c148db94ee040.json"}}, {"family": "Ad\u017ei\u0107-Vuki\u010devi\u0107", "given": "Tatjana", "initials": "T"}, {"family": "Arellano", "given": "Elena", "initials": "E"}, {"family": "Mi\u0161kovi\u0107", "given": "Bojana", "initials": "B"}, {"family": "Mladenovi\u0107", "given": "Milo\u0161", "initials": "M", "orcid": "0000-0002-8350-2182", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6cb8373b8a24520b83e559c9e628eb8.json"}}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "R\u00e1\u010dil", "given": "Zden\u011bk", "initials": "Z", "orcid": "0000-0003-3511-4596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8796025f908f4ba5a37bbdcb8636aecf.json"}}, {"family": "Ammatuna", "given": "Emanuele", "initials": "E", "orcid": "0000-0001-8247-4901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5904d1457399478aaaba50bcc584d502.json"}}, {"family": "Cordoba", "given": "Raul", "initials": "R", "orcid": "0000-0002-7654-8836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14e78d427a5a42c4aa2f063439846f7b.json"}}, {"family": "Hersby", "given": "Ditte Stampe", "initials": "DS", "orcid": "0000-0002-2999-8949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0916e301f874c7caa41b452492466a9.json"}}, {"family": "Gr\u00e4fe", "given": "Stefanie", "initials": "S", "orcid": "0000-0001-7678-0179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6f9279444f64b529761a37a0d2448f4.json"}}, {"family": "Emarah", "given": "Ziad", "initials": "Z", "orcid": "0000-0003-0622-2598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ab9762d99d64abe9098f74d861ef4de.json"}}, {"family": "Hanakova", "given": "Michaela", "initials": "M"}, {"family": "Sacchi", "given": "Maria Vittoria", "initials": "MV", "orcid": "0000-0001-8133-3357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62e9765439304851b3d996f5a4ce6603.json"}}, {"family": "Ijaz", "given": "Marriyam", "initials": "M"}, {"family": "Rahimli", "given": "Laman", "initials": "L", "orcid": "0000-0003-2266-445X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7f04dc07ef64bc99821e22873b88abd.json"}}, {"family": "Nunes Rodrigues", "given": "Raquel", "initials": "R", "orcid": "0000-0002-8347-4281", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59fe3851cbd1404395c359435a99edbf.json"}}, {"family": "Zambrotta", "given": "Giovanni Paolo Maria", "initials": "GPM", "orcid": "0000-0002-8612-2994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa7e3e475561489d8a588f32256d8789.json"}}, {"family": "Marchesi", "given": "Francesco", "initials": "F", "orcid": "0000-0001-6353-2272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e09d8d1e4eb498781444b8d095687a0.json"}}, {"family": "Cornely", "given": "Oliver A", "initials": "OA", "orcid": "0000-0001-9599-3137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3c62d8346924e69b6c99e4007c3831c.json"}}, {"family": "Pagano", "given": "Livio", "initials": "L", "orcid": "0000-0001-8287-928X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbf92a9779614910aeafcc6c21d880e2.json"}}], "type": "journal article", "published": "2023-11-15", "journal": {"title": "Leuk Lymphoma", "issn": "1029-2403", "issn-l": null, "volume": null, "issue": null, "pages": "1-10"}, "abstract": "Since the beginning of the COVID-19 pandemic, there has been an overall improvement in patient mortality. However, haematological malignancy patients continue to experience significant impacts from COVID-19, including high rates of hospitalization, intensive care unit (ICU) admissions, and mortality. In comparison to other haematological malignancy patients, individuals with chronic myeloid leukemia (CML) generally have better prognosis. This study, conducted using a large haematological malignancy patient database (EPICOVIDEHA), demonstrated that the majority of CML patients experienced mild infections. The decline in severe and critical infections over the years can largely be attributed to the widespread administration of vaccinations and the positive response they elicited. Notably, the mortality rate among CML patients was low and exhibited a downward trend in subsequent years. Importantly, our analysis provided confirmation of the effectiveness of vaccinations in CML patients.", "doi": "10.1080/10428194.2023.2280886", "pmid": "37966980", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-12-04T07:21:29.691Z", "modified": "2023-12-07T12:38:00.889Z"}, {"entity": "publication", "iuid": "7472859e351945809c904bdc4f120992", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7472859e351945809c904bdc4f120992.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7472859e351945809c904bdc4f120992"}}, "title": "Compassion fatigue and compassion satisfaction in pediatric and neonatal care nurses during the COVID-19 pandemic in Sweden.", "authors": [{"family": "Blixt", "given": "Cornelia", "initials": "C"}, {"family": "Johansson", "given": "Elin", "initials": "E"}, {"family": "Forsner", "given": "Maria", "initials": "M"}, {"family": "Angelhoff", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2023-11-15", "journal": {"title": "J Pediatr Nurs", "issn": "1532-8449", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Quality of care and the mental and physical health of nurses are interlinked. The COVID-19 pandemic has imposed an extremely high burden on health care. This study aimed to: 1) describe professional quality of life of registered nurses (RN) working in the pediatric and neonatal care units during the COVID-19 pandemic in Sweden, 2) compare professional quality of life between RNs with and without a Master's degree in specialist nursing pediatric care (MSc), and 3) compare differences in professional quality of life associated with the nursing experience (years).\r\n\r\nThis study adopted a cross-sectional survey design. The PROQoL\u00ae-5-questionnaire was administered as a web survey to 160 RNs at four pediatric wards and two neonatal units of two hospitals in Sweden.\r\n\r\nSeventy-one RNs responded to the survey. Overall, they reported a sufficient professional quality of life. RNs with an MSc suffered significantly lower secondary traumatic stress levels. Experienced RNs reported significantly higher compassion satisfaction and lower occupational burnout.\r\n\r\nHigher education and longer experience are beneficial for nurses' professional quality of life when working in pediatric care units.\r\n\r\nResults from this study highlights the importance of offering RN education in pediatric care at master level and supporting novice nurses, to prevent negative professional well-being outcomes in pediatric care, because the health of nurses is of utterly importance when crisis such as a pandemic hits the world. The findings also suggest that the conditions for professional quality of life could improve through activities such as self-care, time for reflection, better working hours, competence-adjusted salary, and educational opportunities.", "doi": "10.1016/j.pedn.2023.11.013", "pmid": "37977972", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0882-5963(23)00332-9"}], "notes": [], "created": "2023-12-04T07:21:19.963Z", "modified": "2023-12-04T08:17:34.467Z"}, {"entity": "publication", "iuid": "7f3f405d6ac543528571bdbb06b10468", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f3f405d6ac543528571bdbb06b10468.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f3f405d6ac543528571bdbb06b10468"}}, "title": "Inequality and COVID-19 in Sweden: Relative risks of nine bad life events, by four social gradients, in pandemic vs. prepandemic years.", "authors": [{"family": "Altmejd", "given": "Adam", "initials": "A", "orcid": "0000-0002-4248-0677", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cf69df3153c4c9ea15d5a4a77c17104.json"}}, {"family": "\u00d6stergren", "given": "Olof", "initials": "O", "orcid": "0000-0002-7156-3260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d22b6331dfb4bd88e2935d0ddec1dd3.json"}}, {"family": "Bj\u00f6rkegren", "given": "Evelina", "initials": "E", "orcid": "0009-0002-4199-6580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2158fdbdcb784347be9cfaff3022ba41.json"}}, {"family": "Persson", "given": "Torsten", "initials": "T"}], "type": "journal article", "published": "2023-11-14", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "issn-l": "0027-8424", "volume": "120", "issue": "46", "pages": "e2303640120"}, "abstract": "The COVID-19 pandemic struck societies directly and indirectly, not just challenging population health but disrupting many aspects of life. Different effects of the spreading virus-and the measures to fight it-are reported and discussed in different scientific fora, with hard-to-compare methods and metrics from different traditions. While the pandemic struck some groups more than others, it is difficult to assess the comprehensive impact on social inequalities. This paper gauges social inequalities using individual-level administrative data for Sweden's entire population. We describe and analyze the relative risks for different social groups in four dimensions-gender, education, income, and world region of birth-to experience three types of COVID-19 incidence, as well as six additional negative life outcomes that reflect general health, access to medical care, and economic strain. During the pandemic, the overall population faced severe morbidity and mortality from COVID-19 and saw higher all-cause mortality, income losses and unemployment risks, as well as reduced access to medical care. These burdens fell more heavily on individuals with low income or education and on immigrants. Although these vulnerable groups experienced larger absolute risks of suffering the direct and indirect consequences of the pandemic, the relative risks in pandemic years (2020 and 2021) were conspicuously similar to those in prepandemic years (2016 to 2019).", "doi": "10.1073/pnas.2303640120", "pmid": "37943837", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null, "Funder: VR": null, "Funder: Forte": null}, "xrefs": [{"db": "pmc", "key": "PMC10655217"}], "notes": [], "created": "2023-12-04T07:17:26.701Z", "modified": "2023-12-04T07:49:00.412Z"}, {"entity": "publication", "iuid": "1bbc233ff8964128a02b28f81b926b1f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1bbc233ff8964128a02b28f81b926b1f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1bbc233ff8964128a02b28f81b926b1f"}}, "title": "Effect of COVID-19 on Bronchiectasis Exacerbation Rates: A Retrospective US Insurance Claims Study.", "authors": [{"family": "\u00c5strand", "given": "Annika", "initials": "A", "orcid": "0000-0002-4231-6682", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2941d27eb5994521b3e009f56e0b06f3.json"}}, {"family": "Kiddle", "given": "Steven J", "initials": "SJ"}, {"family": "Siva Ganesh Mudedla", "given": "Rohith", "initials": "R"}, {"family": "Porwal", "given": "Sanchita", "initials": "S"}, {"family": "Chafekar", "given": "Kaushik", "initials": "K"}, {"family": "Agrawal", "given": "Shubh", "initials": "S"}, {"family": "Seminario", "given": "Carlos", "initials": "C"}, {"family": "Chalmers", "given": "James D", "initials": "JD"}, {"family": "Psallidas", "given": "Ioannis", "initials": "I"}], "type": "journal article", "published": "2023-11-14", "journal": {"title": "Ann Am Thorac Soc", "issn": "2325-6621", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Bronchiectasis is a chronic, progressive disease of bronchial dilation, inflammation, and scarring leading to impaired mucociliary clearance and increased susceptibility to infection. Identified causes include previous severe respiratory infections. A small, single-center UK study demonstrated a reduction in bronchiectasis exacerbations during the first year of the COVID-19 pandemic. No studies have been conducted in a US (commercially insured) cohort to date.\r\n\r\nTo explore the impact of the COVID-19 pandemic on the frequency of exacerbations in a large cohort of commercially insured US patients with bronchiectasis by testing the hypothesis that US patients with bronchiectasis had fewer exacerbations during the pandemic.\r\n\r\nThis retrospective observational cohort study used health insurance claims data from Optum's deidentified Clinformatics\u00ae Data Mart Database, which included US patients and their covered dependents. Eligible patients were aged \uf0b318 years with bronchiectasis; patients with other respiratory conditions were excluded. The main study cohort excluded patients with frequent asthma and/or chronic obstructive pulmonary disease diagnoses. The primary objective was to compare the bronchiectasis exacerbation rate prior to and during the COVID-19 pandemic.\r\n\r\nThe median number of exacerbations per patient per year decreased significantly from the year prior to the COVID-19 pandemic to the first year of the pandemic (1 vs. 0, P < 0.01). More patients had zero exacerbations during the first year of the pandemic than the year prior (57% vs. 24%, McNemar's chi-squared = 122.56, P <0.01).\r\n\r\nIn a U.S. population-based study of patients with ICD codes for bronchiectasis, the rate of exacerbations during year 1 of the COVID-19 pandemic was reduced compared with the 2-year time period preceding the pandemic. Primary Source of Funding (if any): AstraZeneca (Cambridge, UK).", "doi": "10.1513/AnnalsATS.202211-944OC", "pmid": "37962905", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-12-04T07:18:00.850Z", "modified": "2023-12-04T07:59:26.945Z"}, {"entity": "publication", "iuid": "7dfd0dd4385c44f790d21d581c75fcc7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7dfd0dd4385c44f790d21d581c75fcc7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7dfd0dd4385c44f790d21d581c75fcc7"}}, "title": "Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study.", "authors": [{"family": "Kloss", "given": "Philipp", "initials": "P", "orcid": "0009-0006-5424-1290", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47e7bebcfd0e41729b6331175538bfb8.json"}}, {"family": "Lindholz", "given": "Maximilian", "initials": "M", "orcid": "0000-0003-3690-1161", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ff57916db994502a9dc6fc47b334f58.json"}}, {"family": "Milnik", "given": "Annette", "initials": "A", "orcid": "0000-0002-3933-3289", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f78344de2b64fdf861918b93f1eee8c.json"}}, {"family": "Azoulay", "given": "Elie", "initials": "E", "orcid": "0000-0002-8162-1508", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be149aab02dd48498b6b008e119f9946.json"}}, {"family": "Cecconi", "given": "Maurizio", "initials": "M", "orcid": "0000-0002-4376-6538", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79162e2a5da843ee9de35265eacc1d93.json"}}, {"family": "Citerio", "given": "Giuseppe", "initials": "G", "orcid": "0000-0002-5374-3161", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/629ff9a17f4647e5af326467b1252214.json"}}, {"family": "De Corte", "given": "Thomas", "initials": "T", "orcid": "0000-0001-5011-6640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5901255b86c34191815e106debb8a64c.json"}}, {"family": "Duska", "given": "Frantisek", "initials": "F", "orcid": "0000-0003-1559-4078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e34c8d87b5f491ba0e1cd8760db70b0.json"}}, {"family": "Galarza", "given": "Laura", "initials": "L", "orcid": "0000-0002-4658-748X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82e734919a2045e480995be7adab3fed.json"}}, {"family": "Greco", "given": "Massimiliano", "initials": "M", "orcid": "0000-0003-1003-4637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a25a0febf83948fc8d35a2e4122f321c.json"}}, {"family": "Girbes", "given": "Armand R J", "initials": "ARJ", "orcid": "0000-0002-0711-0494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/879982b05a1848e39c9d5f0fbde801ec.json"}}, {"family": "Kesecioglu", "given": "Jozef", "initials": "J", "orcid": "0000-0002-3007-8445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9af039f78ddc46b29b25b2b337c8a01e.json"}}, {"family": "Mellinghoff", "given": "Johannes", "initials": "J", "orcid": "0000-0002-5455-8953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37ddf15c796a4c2ea172764a6c36f9d0.json"}}, {"family": "Ostermann", "given": "Marlies", "initials": "M", "orcid": "0000-0001-9500-9080", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc42fc57504149a29d3ffef5efd9852c.json"}}, {"family": "Pellegrini", "given": "Mariangela", "initials": "M", "orcid": "0000-0001-5668-7399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/97386683452a4afd9e1da948bb9921f2.json"}}, {"family": "Teboul", "given": "Jean-Louis", "initials": "J"}, {"family": "De Waele", "given": "Jan", "initials": "J", "orcid": "0000-0003-1017-9748", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/875fffe346d548b19bd3c0e0ff6fb267.json"}}, {"family": "Wong", "given": "Adrian", "initials": "A", "orcid": "0000-0003-4968-7328", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/338f961fbb48481f893f697e5dfc1d67.json"}}, {"family": "Schaller", "given": "Stefan J", "initials": "SJ", "orcid": "0000-0002-6683-9584", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5c134bb75e14b94bc723f59b7dd790e.json"}}, {"family": "ESICM UNITE COVID Investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2023-11-14", "journal": {"title": "Ann Intensive Care", "issn": "2110-5820", "issn-l": null, "volume": "13", "issue": "1", "pages": "112"}, "abstract": "Early mobilisation (EM) is an intervention that may improve the outcome of critically ill patients. There is limited data on EM in COVID-19 patients and its use during the first pandemic wave.\r\n\r\nThis is a pre-planned subanalysis of the ESICM UNITE-COVID, an international multicenter observational study involving critically ill COVID-19 patients in the ICU between February 15th and May 15th, 2020. We analysed variables associated with the initiation of EM (within 72 h of ICU admission) and explored the impact of EM on mortality, ICU and hospital length of stay, as well as discharge location. Statistical analyses were done using (generalised) linear mixed-effect models and ANOVAs.\r\n\r\nMobilisation data from 4190 patients from 280 ICUs in 45 countries were analysed. 1114 (26.6%) of these patients received mobilisation within 72 h after ICU admission; 3076 (73.4%) did not. In our analysis of factors associated with EM, mechanical ventilation at admission (OR 0.29; 95% CI 0.25, 0.35; p = 0.001), higher age (OR 0.99; 95% CI 0.98, 1.00; p \u2264 0.001), pre-existing asthma (OR 0.84; 95% CI 0.73, 0.98; p = 0.028), and pre-existing kidney disease (OR 0.84; 95% CI 0.71, 0.99; p = 0.036) were negatively associated with the initiation of EM. EM was associated with a higher chance of being discharged home (OR 1.31; 95% CI 1.08, 1.58; p = 0.007) but was not associated with length of stay in ICU (adj. difference 0.91 days; 95% CI - 0.47, 1.37, p = 0.34) and hospital (adj. difference 1.4 days; 95% CI - 0.62, 2.35, p = 0.24) or mortality (OR 0.88; 95% CI 0.7, 1.09, p = 0.24) when adjusted for covariates.\r\n\r\nOur findings demonstrate that a quarter of COVID-19 patients received EM. There was no association found between EM in COVID-19 patients' ICU and hospital length of stay or mortality. However, EM in COVID-19 patients was associated with increased odds of being discharged home rather than to a care facility. Trial registration ClinicalTrials.gov: NCT04836065 (retrospectively registered April 8th 2021).", "doi": "10.1186/s13613-023-01201-1", "pmid": "37962748", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10645963"}, {"db": "pii", "key": "10.1186/s13613-023-01201-1"}, {"db": "ClinicalTrials.gov", "key": "NCT04836065"}], "notes": [], "created": "2023-12-04T07:18:24.292Z", "modified": "2023-12-04T08:10:56.813Z"}, {"entity": "publication", "iuid": "e01dec81018443e792b2ddf21655e90a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e01dec81018443e792b2ddf21655e90a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e01dec81018443e792b2ddf21655e90a"}}, "title": "Australian adults cooked more and tried new recipes during COVID-19 restrictions and lockdowns.", "authors": [{"family": "Margerison", "given": "Claire", "initials": "C"}, {"family": "Aydin", "given": "Gozde", "initials": "G"}, {"family": "Larsson", "given": "Christel", "initials": "C"}, {"family": "Booth", "given": "Alison", "initials": "A"}, {"family": "Worsley", "given": "Anthony", "initials": "A"}, {"family": "Nanayakkara", "given": "Janandani", "initials": "J"}], "type": "journal article", "published": "2023-11-14", "journal": {"title": "Appetite", "issn": "1095-8304", "issn-l": null, "volume": "193", "issue": null, "pages": "107122"}, "abstract": "The lockdowns and restrictions due to COVID-19 caused changes in both food accessibility and availability for people around the globe resulting in changes in food habits and behaviours. To enable a better public health response to the next pandemic, lessons must be learnt from this most recent emergency. This study aimed to examine self-reported changes in food habits and behaviours, of Australian adults during COVID-19 restrictions in 2020. A cross-sectional, convenience, Australia-wide survey, with open-ended and closed-ended questions was conducted online. Respondents were asked to report their demographic characteristics, positive food habit development, worst food-related experiences, changes in food habits and behaviours and cooking and food preparation practices during the COVID-19 restriction period. Adult Australian residents, recruited through social media advertising of the survey. Respondents (n = 764) were mostly female (86%), over 55 years of age (57%, mean age (SD) 53.4 (18.1) years), and half (51%) were not in paid employment. Nearly two-thirds (63%) developed positive food habits, including trying new recipes (54%), eating less take-away (53%) and cooking from scratch (46%) during the COVID-19 restrictions. Furthermore, respondents reported including family members in food preparation and eating together as a family. Negative experiences included being unable to buy certain foods (due to lack of stock and store limits), cooking at home, and being unable to access some food outlets. Australians experienced both positive and negative food experiences during the COVID-19 pandemic and associated lockdown periods, with most experiencing positive changes such as cooking at home from scratch and trying new recipes and relying on less take-away. Females and those who experienced a change in employment status were more likely to develop positive new food habits.", "doi": "10.1016/j.appet.2023.107122", "pmid": "37972657", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0195-6663(23)02584-9"}], "notes": [], "created": "2023-12-04T07:18:11.813Z", "modified": "2023-12-04T08:04:05.090Z"}, {"entity": "publication", "iuid": "5f6fc6f7b8214129970b9ff30aa9bea9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f6fc6f7b8214129970b9ff30aa9bea9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f6fc6f7b8214129970b9ff30aa9bea9"}}, "title": "In their absence; intensive care nurses' experiences of communicating and supporting relatives from a distance.", "authors": [{"family": "Conte", "given": "Helen", "initials": "H", "orcid": "0000-0002-6967-528X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bd58277c2684b7baf50d2d4d79f84e2.json"}}, {"family": "Dorell", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0003-1413-7916", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84070b2733e743229415593f2ebd8fff.json"}}, {"family": "Wedin", "given": "Emilia", "initials": "E"}, {"family": "Eckerblad", "given": "Jeanette", "initials": "J", "orcid": "0000-0002-8241-4973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2eff6313e07f469ea11fb2f49ace934f.json"}}], "type": "journal article", "published": "2023-11-10", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "issn-l": null, "volume": "22", "issue": "1", "pages": "421"}, "abstract": "Having a critically ill family member in the intensive care unit (ICU) is a challenging situation and ICU nurses play an important part in supporting relatives to make sense of the situation. Strict visiting policies inhibited the family's presence in ICUs during 2020-22, and the communication between nurses and families changed drastically. Information and support are at the core of the ICU nurses' profession, and the pandemic backdrop created a split between what intensive care nurses have a professional responsibility to perform and which actions were possible. To get a fuller picture, the aim of this study was: To describe intensive care nurses' experiences of communicating and supporting relatives from a distance while working during visiting restrictions.\r\n\r\nA qualitative descriptive design using individual and semi-structured interviews with 16 ICU nurses. The interviews were analyzed using inductive thematic analysis. This study followed the consolidated criteria for reporting qualitative research (COREQ).\r\n\r\nDue to the visiting restriction during the COVID-19 pandemic, ICU nurses found themselves in a situation where proximity and time to develop an interpersonal connection with relatives disappeared overnight. The nurses' experiences of communicating with and supporting families is described in three themes: \"Finding ways to create order out of chaos\"; \"Guiding the relatives to a fuller picture of the situation\"; and \"Feeling insufficient in their support\".\r\n\r\nVisiting restrictions in the ICU meant that ICU nurses missed vital information about their patients as a person, which might have had a negative effect on personalizing and centring the patient care. But using a combination of digital and audio tools helped nurses to guide the relatives to a clearer picture of the situation as a whole. The support that nurses were able to provide to relatives was often insufficient due to the visiting restriction and as a consequence, they experienced physical and psychological stress.", "doi": "10.1186/s12912-023-01559-4", "pmid": "37950204", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10636861"}, {"db": "pii", "key": "10.1186/s12912-023-01559-4"}], "notes": [], "created": "2023-12-04T07:22:00.454Z", "modified": "2023-12-08T06:05:06.398Z"}, {"entity": "publication", "iuid": "950810ae84c34b23bf0c19681e1195a7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/950810ae84c34b23bf0c19681e1195a7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/950810ae84c34b23bf0c19681e1195a7"}}, "title": "Absenteeism Costs Due to COVID-19 and Their Predictors in Non-Hospitalized Patients in Sweden: A Poisson Regression Analysis.", "authors": [{"family": "Kisiel", "given": "Marta A", "initials": "MA", "orcid": "0000-0002-0410-1509", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0b59298d5ea4cdd86322da52bb78773.json"}}, {"family": "Lee", "given": "Seika", "initials": "S"}, {"family": "Janols", "given": "Helena", "initials": "H", "orcid": "0000-0002-3857-163X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc81fb116a4642e8ad5ae396d3be2c4f.json"}}, {"family": "Faramarzi", "given": "Ahmad", "initials": "A"}], "type": "journal article", "published": "2023-11-10", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "20", "issue": "22", "pages": null}, "abstract": "This study aimed to estimate absenteeism costs and identify their predictors in non-hospitalized patients in Sweden.\r\n\r\nThis cross-sectional study's data were derived from the longitudinal project conducted at Uppsala University Hospital. The mean absenteeism costs due to COVID-19 were calculated using the human capital approach, and a Poisson regression analysis was employed to determine predictors of these costs.\r\n\r\nThe findings showed that the average absenteeism cost due to COVID-19 was USD 1907.1, compared to USD 919.4 before the pandemic (p < 0.001). Notably, the average absenteeism cost for females was significantly higher due to COVID-19 compared to before the pandemic (USD 1973.5 vs. USD 756.3, p = 0.001). Patients who had not fully recovered at the 12-month follow-up exhibited significantly higher costs than those without symptoms at that point (USD 3389.7 vs. USD 546.7, p < 0.001). The Poisson regression revealed that several socioeconomic factors, including age, marital status, country of birth, educational level, smoking status, BMI, and occupation, along with COVID-19-related factors such as severity at onset, pandemic wave, persistent symptoms at the follow-up, and newly introduced treatment for depression after the infection, were significant predictors of the absenteeism costs.\r\n\r\nOur study reveals that the mean absenteeism costs due to COVID-19 doubled compared to the year preceding the pandemic. This information is invaluable for decision-makers and contributes to a better understanding of the economic aspects of COVID-19.", "doi": "10.3390/ijerph20227052", "pmid": "37998283", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10671172"}, {"db": "pii", "key": "ijerph20227052"}], "notes": [], "created": "2023-12-04T07:17:18.768Z", "modified": "2023-12-04T07:44:40.344Z"}, {"entity": "publication", "iuid": "f412bb8763914021a92bba986751c3b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f412bb8763914021a92bba986751c3b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f412bb8763914021a92bba986751c3b3"}}, "title": "The Validity of the ROX Index and APACHE II in Predicting Early, Late, and Non-Responses to Non-Invasive Ventilation in Patients with COVID-19 in a Low-Resource Setting.", "authors": [{"family": "Arunachala", "given": "Sumalatha", "initials": "S", "orcid": "0000-0001-5858-8298", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec761000c8c1429ba3459dcd08529abf.json"}}, {"family": "Parthasarathi", "given": "Ashwaghosha", "initials": "A", "orcid": "0000-0002-7270-0247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c0a5e6837a421cbbb0314628ae7f24.json"}}, {"family": "Basavaraj", "given": "Chetak Kadabasal", "initials": "CK", "orcid": "0000-0002-7422-8353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dea3044d43fb4b648b46945d7cb39367.json"}}, {"family": "Kaleem Ullah", "given": "Mohammed", "initials": "M", "orcid": "0000-0001-8470-3114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1645033dc8e84aa493a444301f0403ad.json"}}, {"family": "Chandran", "given": "Shreya", "initials": "S"}, {"family": "Venkataraman", "given": "Hariharan", "initials": "H"}, {"family": "Vishwanath", "given": "Prashant", "initials": "P"}, {"family": "Ganguly", "given": "Koustav", "initials": "K", "orcid": "0000-0001-8531-8154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58b2e0d7853a4b32920e54042e95061d.json"}}, {"family": "Upadhyay", "given": "Swapna", "initials": "S", "orcid": "0000-0003-4699-4082", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c98621d4161241dd9379dca3fa6e1bf1.json"}}, {"family": "Mahesh", "given": "Padukudru Anand", "initials": "PA", "orcid": "0000-0003-1632-5945", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70c3b10ccc334c4c8195556f07c862d0.json"}}], "type": "journal article", "published": "2023-11-08", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "15", "issue": "11", "pages": null}, "abstract": "The use of the Ratio of Oxygen Saturation (ROX) index to predict the success of high-flow nasal oxygenation (HFNO) is well established. The ROX can also predict the need for intubation, mortality, and is easier to calculate compared with APACHE II. In this prospective study, the primary aim is to compare the ROX (easily administered in resource limited setting) to APACHE II for clinically relevant outcomes such as mortality and the need for intubation. Our secondary aim was to identify thresholds for the ROX index in predicting outcomes such as the length of ICU stay and failure of non-invasive respiratory support therapies and to assess the effectiveness of using the ROX (day 1 at admission, day 2, and day 3) versus Acute physiology and chronic health evaluation (APACHE) II scores (at admission) in patients with Coronavirus Disease 2019 (COVID-19) pneumonia and Acute Respiratory Distress Syndrome (ARDS) to predict early, late, and non-responders. After screening 208 intensive care unit patients, a total of 118 COVID-19 patients were enrolled, who were categorized into early (n = 38), late (n = 34), and non-responders (n = 46). Multinomial logistic regression, receiver operating characteristic (ROC), Multivariate Cox regression, and Kaplan-Meier analysis were conducted. Multinomial logistic regressions between late and early responders and between non- and early responders were associated with reduced risk of treatment failures. ROC analysis for early vs. late responders showed that APACHE II on admission had the largest area under the curve (0.847), followed by the ROX index on admission (0.843). For responders vs. non-responders, we found that the ROX index on admission had a slightly better AUC than APACHE II on admission (0.759 vs. 0.751). A higher ROX index on admission [HR (95% CI): 0.29 (0.13-0.52)] and on day 2 [HR (95% CI): 0.55 (0.34-0.89)] were associated with a reduced risk of treatment failure. The ROX index can be used as an independent predictor of early response and mortality outcomes to HFNO and NIV in COVID-19 pneumonia, especially in low-resource settings, and is non-inferior to APACHE II.", "doi": "10.3390/v15112231", "pmid": "38005908", "labels": {"Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10675664"}, {"db": "pii", "key": "v15112231"}], "notes": [], "created": "2023-12-04T07:21:50.000Z", "modified": "2023-12-08T05:59:30.190Z"}, {"entity": "publication", "iuid": "b624109f710f4b2bb88bf07e30eb2b47", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b624109f710f4b2bb88bf07e30eb2b47.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b624109f710f4b2bb88bf07e30eb2b47"}}, "title": "Research on transportation management model of COVID-19 medical waste: a case study in Beijing, China.", "authors": [{"family": "Liu", "given": "Hao", "initials": "H", "orcid": "0000-0001-9788-7880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a6004a59748404e8a657e1afb55deea.json"}}, {"family": "Yao", "given": "Zhong", "initials": "Z"}, {"family": "Meijer", "given": "Sebastiaan", "initials": "S"}], "type": "journal article", "published": "2023-11-08", "journal": {"title": "Environ Sci Pollut Res Int", "issn": "1614-7499", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "During the COVID-19 pandemic, disposable masks, protective clothing, gloves, and nasopharyngeal swabs collected by nucleic acid testing formed a large amount of medical waste. Medical waste has strict temporary storage time requirements in hospitals, which need to be transported to medical waste disposal plants within the specified time. However, as most of disposal plants are far away from downtown, they also need to be responsible for the transportation and disposal of medical waste in many hospitals, and put forward higher requirement for transportation routes. Rapid and safe disposal of all types of medical waste generated by COVID-19 is crucial to the prevention and control of the epidemic. This paper designs the transportation route optimization model using Anylogic simulation software based on the regional distribution of 118 tertiary hospitals and 2 large medical waste disposal plants in Beijing, China. At the same time, transportation routes of 118 tertiary hospitals in the morning peak, evening peak, all-day, and ordinary periods were simulated based on the Beijing traffic index in 2017. On this basis, through the analysis of the simulation data, the selection of medical waste transport routes for 118 tertiary hospitals in the morning peak, evening peak, all day, and ordinary periods is further clarified, so as to ensure that medical waste can be transported to the medical waste disposal plant in the shortest time. The shortest path and fastest speed transport mode, medical waste transport data set, and the selection of transport mode of 118 tertiary hospitals formed by this research provide certain reference experience for the rapid and safe transport of medical waste during the epidemic period, and also provides corresponding data support for medical waste transportation management in the post-epidemic era and medical waste transportation decision-making when facing major public health problems.", "doi": "10.1007/s11356-023-30605-6", "pmid": "37936037", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11356-023-30605-6"}], "notes": [], "created": "2023-12-04T07:21:39.923Z", "modified": "2023-12-07T12:40:03.112Z"}, {"entity": "publication", "iuid": "dfaf4229ea2c4570810563f0a65176f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dfaf4229ea2c4570810563f0a65176f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dfaf4229ea2c4570810563f0a65176f1"}}, "title": "Global impacts of COVID-19 pandemic on sexual and reproductive health services: An international comparative study on primary care from the INTRePID Consortium.", "authors": [{"family": "Peng", "given": "Kangning", "initials": "K", "orcid": "0009-0002-2693-1615", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8fafaf68b0546bc9d83c672350c0976.json"}}, {"family": "Tu", "given": "Karen", "initials": "K", "orcid": "0000-0003-0883-4934", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5086562fe34a4a72834516124504d597.json"}}, {"family": "Li", "given": "Zhuo", "initials": "Z", "orcid": "0000-0002-2478-2356", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9052afd0ef834630b00ad0ba94fd15e0.json"}}, {"family": "Hallinan", "given": "Christine Mary", "initials": "CM", "orcid": "0000-0002-0471-4444", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/246d6cc9749e40aa9e8a9e7d18bdacf6.json"}}, {"family": "Laughlin", "given": "Adrian", "initials": "A", "orcid": "0000-0003-3545-4785", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f4e4e1c7bde4eefacc198422acfbfa6.json"}}, {"family": "Manski-Nankervis", "given": "Jo-Anne", "initials": "J"}, {"family": "Apajee", "given": "Jemisha", "initials": "J", "orcid": "0000-0002-3847-1604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77d732b7954d4d9a83a573d4795224ae.json"}}, {"family": "Lapadula", "given": "Mar\u00eda Carla", "initials": "MC", "orcid": "0000-0001-5156-121X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a70ba53b70c40f48137c79f6a8f76bc.json"}}, {"family": "Ortigoza", "given": "Angela", "initials": "A", "orcid": "0000-0003-1048-4216", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d5d938eb2914a6491d17b3621dc5dfc.json"}}, {"family": "Da Roza", "given": "Cecilia Clara", "initials": "CC", "orcid": "0009-0005-8900-8790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d2bbf7bc33648d2b3434509145ee222.json"}}, {"family": "Baste", "given": "Valborg", "initials": "V", "orcid": "0000-0001-6640-9747", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f46ec95f421410f8cbea7f76adfa5b0.json"}}, {"family": "Flottorp", "given": "Signe", "initials": "S", "orcid": "0000-0003-2961-7461", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82d07858cb4f466a89042b10ff7de05c.json"}}, {"family": "Wensaas", "given": "Knut-Arne", "initials": "K"}, {"family": "Goh", "given": "Lay Hoon", "initials": "LH", "orcid": "0000-0003-1536-3050", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e099a9f99554dbda150ba9efc517219.json"}}, {"family": "Ling", "given": "Zheng Jye", "initials": "ZJ", "orcid": "0000-0001-9584-4473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d2c1532892648fbaacf9218ac84c5ce.json"}}, {"family": "Kristiansson", "given": "Robert", "initials": "R", "orcid": "0000-0002-3036-1048", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d907aca6a3b45cc940039bd126fd556.json"}}, {"family": "Gaona", "given": "Gabriela", "initials": "G", "orcid": "0009-0003-6767-4819", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06dfa1f570c743d191ac901194a67daf.json"}}, {"family": "Pace", "given": "Wilson D", "initials": "WD", "orcid": "0000-0003-1699-5471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb222b6c1609418383f0e050b1203cfd.json"}}, {"family": "Westfall", "given": "John M", "initials": "JM", "orcid": "0000-0002-1070-0268", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af1a2a43a19b42d28be345960c3c5ad3.json"}}, {"family": "Ng", "given": "Amy Pui Pui", "initials": "APP", "orcid": "0000-0003-3867-6447", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceef0a2d3ef0472fa6c64c58295f45a8.json"}}, {"family": "Wong", "given": "William Chi-Wai", "initials": "WC", "orcid": "0000-0003-2540-4055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2fb491d98344c5d969215333a4d6653.json"}}], "type": "journal article", "published": "2023-11-07", "journal": {"title": "BJOG", "issn": "1471-0528", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To understand how the COVID-19 pandemic has impacted sexual and reproductive health (SRH) visits.\r\n\r\nAn ecological study comparing SRH services volume in different countries before and after the onset of the COVID-19 pandemic.\r\n\r\nSeven countries from the INTernational ConsoRtium of Primary Care BIg Data Researchers (INTRePID) across four continents.\r\n\r\nOver 3.8 million SRH visits to primary care physicians in Australia, China, Canada, Norway, Singapore, Sweden and the USA.\r\n\r\nDifference in average SRH monthly visits before and during the pandemic, with negative binomial regression modelling to compare predicted and observed number of visits during the pandemic for SRH visits.\r\n\r\nMonthly number of visits to primary care physicians from 2018 to 2021.\r\n\r\nDuring the pandemic, the average volume of monthly SRH visits increased in Canada (15.6%, 99% CI 8.1-23.0%) where virtual care was pronounced. China, Singapore, Sweden and the USA experienced a decline (-56.5%, 99% CI -74.5 to -38.5%; -22.7%, 99% CI -38.8 to -6.5%; -19.4%, 99% CI -28.3 to -10.6%; and -22.7%, 99% CI -38.8 to -6.5%, respectively); while Australia and Norway showed insignificant changes (6.5%, 99% CI -0.7 to -13.8% and 1.7%, 99% CI -6.4 to -9.8%). The countries that maintained (Australia, Norway) or surpassed (Canada) pre-pandemic visit rates had the greatest use of virtual care.\r\n\r\nIn-person SRH visits to primary care decreased during the pandemic. Virtual care seemed to counterbalance that decline. Although cervical cancer screening appeared insensitive to virtual care, strategies such as incorporating self-collected samples for HPV testing may provide a solution in a future pandemic.", "doi": "10.1111/1471-0528.17704", "pmid": "37935645", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-12-04T07:22:03.149Z", "modified": "2023-12-08T06:06:23.974Z"}, {"entity": "publication", "iuid": "050221ddba87425e97e1294fd44a25b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/050221ddba87425e97e1294fd44a25b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/050221ddba87425e97e1294fd44a25b2"}}, "title": "Systematic review of seroprevalence of SARS-CoV-2 antibodies and appraisal of evidence, prior to the widespread introduction of vaccine programmes in the WHO European Region, January-December 2020.", "authors": [{"family": "Vaughan", "given": "Aisling", "initials": "A", "orcid": "0000-0002-5966-2303", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c63dcc675d0b4864b935d31792a919fe.json"}}, {"family": "Duffell", "given": "Erika", "initials": "E"}, {"family": "Freidl", "given": "Gudrun S", "initials": "GS"}, {"family": "Lemos", "given": "Diogo Sim\u00e3o", "initials": "DS"}, {"family": "Nardone", "given": "Anthony", "initials": "A"}, {"family": "Valenciano", "given": "M", "initials": "M"}, {"family": "Subissi", "given": "Lorenzo", "initials": "L"}, {"family": "Bergeri", "given": "Isabel", "initials": "I"}, {"family": "K Broberg", "given": "Eeva", "initials": "E", "orcid": "0000-0003-2693-7224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d36a7d92aff486a9afa0d71ad8f4588.json"}}, {"family": "Penttinen", "given": "Pasi", "initials": "P"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "Keramarou", "given": "Maria", "initials": "M"}], "type": "systematic review", "published": "2023-11-06", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "11", "pages": "e064240"}, "abstract": "Systematic review of SARS-CoV-2 seroprevalence studies undertaken in the WHO European Region to measure pre-existing and cumulative seropositivity prior to the roll out of vaccination programmes.\r\n\r\nA systematic review of the literature.\r\n\r\nWe searched MEDLINE, EMBASE and the preprint servers MedRxiv and BioRxiv in the WHO 'COVID-19 Global literature on coronavirus disease' database using a predefined search strategy. Articles were supplemented with unpublished WHO-supported Unity-aligned seroprevalence studies and other studies reported directly to WHO Regional Office for Europe and European Centre for Disease Prevention and Control.\r\n\r\nStudies published before the widespread implementation of COVID-19 vaccination programmes in January 2021 among the general population and blood donors, at national and regional levels.\r\n\r\nAt least two independent researchers extracted the eligible studies; a third researcher resolved any disagreements. Study risk of bias was assessed using a quality scoring system based on sample size, sampling and testing methodologies.\r\n\r\nIn total, 111 studies from 26 countries published or conducted between 1 January 2020 and 31 December 2020 across the WHO European Region were included. A significant heterogeneity in implementation was noted across the studies, with a paucity of studies from the east of the Region. Sixty-four (58%) studies were assessed to be of medium to high risk of bias. Overall, SARS-CoV-2 seropositivity prior to widespread community circulation was very low. National seroprevalence estimates after circulation started ranged from 0% to 51.3% (median 2.2% (IQR 0.7-5.2%); n=124), while subnational estimates ranged from 0% to 52% (median 5.8% (IQR 2.3%-12%); n=101), with the highest estimates in areas following widespread local transmission.\r\n\r\nThe low levels of SARS-CoV-2 antibody in most populations prior to the start of vaccine programmes underlines the critical importance of targeted vaccination of priority groups at risk of severe disease, while maintaining reduced levels of transmission to minimise population morbidity and mortality.", "doi": "10.1136/bmjopen-2022-064240", "pmid": "37931969", "labels": {"Type: Journal article": null, "Category: Serology": null}, "xrefs": [{"db": "pmc", "key": "PMC10632881"}, {"db": "pii", "key": "bmjopen-2022-064240"}], "notes": [], "created": "2023-12-04T07:16:58.717Z", "modified": "2023-12-04T07:37:09.404Z"}, {"entity": "publication", "iuid": "51fa9dcfa576418daf98312c284ae055", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/51fa9dcfa576418daf98312c284ae055.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/51fa9dcfa576418daf98312c284ae055"}}, "title": "Clinical outcomes during and beyond different COVID-19 critical illness variant periods compared with other lower respiratory tract infections.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P", "orcid": "0000-0003-3153-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd6af5accfc84ff9a81983a5ab6683aa.json"}}, {"family": "Baltzer", "given": "Nicholas", "initials": "N"}, {"family": "Granath", "given": "Fredrik", "initials": "F"}, {"family": "Fored", "given": "Michael", "initials": "M"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2023-11-06", "journal": {"title": "Crit Care", "issn": "1466-609X", "issn-l": "1364-8535", "volume": "27", "issue": "1", "pages": "427"}, "abstract": "It is yet to be better understood how outcomes during and after the critical illness potentially differ between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants from other lower respiratory tract infections (LRTIs). We aimed to compare outcomes in adults admitted to an intensive care unit (ICU) with coronavirus disease 2019 (COVID-19) during the Wild-type, Alpha, Delta, and Omicron periods with individuals admitted with other LRTI.\r\n\r\nPopulation-based cohort study in Stockholm, Sweden, using health registries with high coverage, including ICU-admitted adults from 1 January 2016 to 15 September 2022. Outcomes were in-hospital mortality, 180-day post-discharge mortality, 180-day hospital readmission, 180-day days alive and at home (DAAH), and incident diagnoses registered during follow-up.\r\n\r\nThe number of ICU admitted individuals were 1421 Wild-type, 551 Alpha, 190 Delta, 223 Omicron, and 2380 LRTI. In-hospital mortality ranged from 28% (n = 665) in the LRTI cohort to 35% (n = 77) in the Delta cohort. The adjusted cause-specific hazard ratio (CSHR) compared with the LRTI cohort was 1.33 (95% confidence interval [CI] 1.16-1.53) in the Wild-type cohort, 1.53 (1.28-1.82) in the Alpha cohort, 1.70 (1.30-2.24) in the Delta cohort, and 1.59 (1.24-2.02) in the Omicron cohort. Among patients discharged alive from their COVID-19 hospitalization, the post-discharge mortality rates were lower (1-3%) compared with the LRTI cohort (9%), and the risk of hospital readmission was lower (CSHRs ranging from 0.42 to 0.68). Moreover, all COVID-19 cohorts had compared with the LRTI cohort more DAAH after compared with before the critical illness.\r\n\r\nOverall, COVID-19 critical was associated with an increased hazard of in-hospital mortality, but among those discharged alive from the hospital, less severe long-term outcomes were observed compared with other LRTIs.", "doi": "10.1186/s13054-023-04722-0", "pmid": "37932793", "labels": {"Category: Health": null, "Funder: H2020": null, "Type: Journal article": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC10629059"}, {"db": "pii", "key": "10.1186/s13054-023-04722-0"}], "notes": [], "created": "2023-12-04T07:16:55.568Z", "modified": "2023-12-04T07:35:52.922Z"}, {"entity": "publication", "iuid": "c2d63f2534704bab8975066397b41e01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2d63f2534704bab8975066397b41e01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2d63f2534704bab8975066397b41e01"}}, "title": "COVID-19 and mental health in the UK: Depression, anxiety and insomnia and their associations with persistent physical symptoms and risk and vulnerability factors.", "authors": [{"family": "Yu", "given": "Lin", "initials": "L", "orcid": "0000-0003-0038-9266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e37b2c9f27c40f29b16925344a92cc2.json"}}, {"family": "McCracken", "given": "Lance M", "initials": "LM", "orcid": "0000-0002-9734-0153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e7520672ca04462b00b191b756a1b7a.json"}}], "type": "journal article", "published": "2023-11-06", "journal": {"title": "Br J Clin Psychol", "issn": "0144-6657", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Mental health problems and persistent COVID-19 symptoms were prevalent in the context of COVID-19. However, despite the long-observed association between physical symptoms and mental health problems, such association has not been adequately examined in the context of COVID-19. Our understanding of wider patterns of risk and vulnerability factors for mental health also remains limited. This study investigated the associations between general mental health, and persistent physical symptoms, and additional risk and vulnerability factors in the context of COVID-19.\r\n\r\nTwo hundred fourteen adults, living in the UK, recruited via social media, completed the online survey and were included in the analyses. Correlation and regression analyses were conducted to examine the associations of persistent physical symptoms and risk and vulnerability factors with measures of general mental health including depressive symptoms, anxiety and insomnia.\r\n\r\n78.5% of the participants reported between 1 and 26 persistent symptoms, and about 28%-92% of them associated these symptoms with COVID-19 infection. Persistent physical symptoms were uniquely associated with all measures of mental health, \u03b2 = .19-.32. Mental health history and worries were the most prominent risk factors, |\u03b2| = .12-.43.\r\n\r\nPeople who experience more persistent physical symptoms post-COVID-19 have poorer mental health. It may be important to consider and discuss the recovery from COVID-19 beyond a negative COVID-19 test. Multidisciplinary interventions that address the complex impact of COVID-19 for people with long COVID are needed.", "doi": "10.1111/bjc.12446", "pmid": "37929759", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-12-04T07:17:10.617Z", "modified": "2023-12-04T07:40:10.834Z"}, {"entity": "publication", "iuid": "8919e7e19ca4497f8200226738fd2261", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8919e7e19ca4497f8200226738fd2261.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8919e7e19ca4497f8200226738fd2261"}}, "title": "Association of maternal SARS-CoV-2 infection at the time of admission for delivery with labor process and outcomes of vaginal birth: A cohort study.", "authors": [{"family": "Chen", "given": "An", "initials": "A", "orcid": "0000-0001-9419-8254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81fa225490b8418693686d953188c52c.json"}}, {"family": "Acharya", "given": "Ganesh", "initials": "G", "orcid": "0000-0002-1997-3107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d1c2ac0dfb849d8b2374451e38cdcba.json"}}, {"family": "Hu", "given": "Min", "initials": "M"}, {"family": "Gao", "given": "Xin", "initials": "X"}, {"family": "Cheng", "given": "Guizhi", "initials": "G"}, {"family": "Jiang", "given": "Lai", "initials": "L"}, {"family": "Ni", "given": "Qianqian", "initials": "Q", "orcid": "0000-0003-2907-6888", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4c4f0b0477c4d80af90838a17f65546.json"}}], "type": "journal article", "published": "2023-11-05", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "issn-l": "0001-6349", "volume": null, "issue": null, "pages": null}, "abstract": "This study aimed to investigate the impact of maternal SARS-CoV-2 infection at the time of admission for delivery on labor process and outcomes of vaginal birth.\r\n\r\nA cohort study was carried out at the Obstetrics Department of Anhui Provincial Hospital, China, where universal reverse transcriptase polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 infection was introduced for all women admitted for labor and delivery from December 1-31, 2022. Women were divided into positive and negative groups based on the test result. All women having a singleton vaginal birth were included in final analysis. The effect of SARS-CoV-2 positivity on labor process and outcomes of vaginal birth was estimated by regression analyses.\r\n\r\nAmong a total of 360 women included, 87 had a positive SARS-CoV-2 test and 273 a negative test. Women in the positive group had an increased likelihood of having longer labor (median 9.3 vs 8.3 hours; sB [log-transformed] 0.19; 95% confidence interval [CI] 0.09-0.28), episiotomy (39.1% vs 23.8%; adjusted odds ratio [aOR] 2.31; 95% CI 1.27-4.21), grade III meconium-stained amniotic fluid (19.5% vs 7.0%; aOR 2.52; 95% CI 1.15-5.54) and postpartum hospital stay exceeding 37 hours (58.6% vs 46.5%; aOR 1.71; 95% CI 1.00-2.91). They had reduced rates exclusive breastfeeding (26.7% vs 39%; aOR 0.21; 95% CI 0.09-0.46) as well as mixed feeding (46.5% vs 52.2%; aOR 0.28; 95% CI 0.13-0.60) at 1 week postpartum. No significant differences were observed in other aspects of labor process and birth outcomes, including the uptake of labor analgesia, postpartum hemorrhage (>500 mL) or neonatal outcomes.\r\n\r\nA positive maternal SARS-CoV-2 test in labor among women having vaginal birth was associated with a slightly longer duration of labor, increased likelihood of episiotomy, increased incidence of grade III meconium-stained amniotic fluid, a longer postpartum hospital stay and a lower rate of breastfeeding 1 week postpartum. However, it did not have an adverse impact on other birth outcomes.", "doi": "10.1111/aogs.14704", "pmid": "37926941", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-12-04T07:21:57.953Z", "modified": "2023-12-08T06:03:51.376Z"}, {"entity": "publication", "iuid": "65fa3b75224d4d76880140ea4af846bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65fa3b75224d4d76880140ea4af846bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65fa3b75224d4d76880140ea4af846bf"}}, "title": "Psychosocial work environment and mental health among the global workforce of seafarers in the wake of the COVID-19 pandemic.", "authors": [{"family": "Hayes-Mejia", "given": "Rebecca", "initials": "R"}, {"family": "Stafstr\u00f6m", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2023-11-03", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "23", "issue": "1", "pages": "2151"}, "abstract": "The aim of this study was to investigate the impact of the COVID-19 pandemic on the mental health outcomes of international seafarers, who played a crucial role in maintaining global trade during the pandemic. The study examined how changes in psychosocial work environment and policies affected mental health outcomes among seafarers.\r\n\r\nWe analyzed a survey including answers from 17,861 seafarers, serving on 44 different international commercial vessels with 154 different nationalities. Stress, anxiety, and depression were applied as outcome measures in this study. Three sets of independent variables were included; work-related consequences of the COVID-19 pandemic, general psychosocial work environment onboard, and socioeconomic variables. First, we applied binary linear regression, followed by a multivariate linear regression analysis.\r\n\r\nThe study found that changes in safety consciousness and clear communication from employers were associated with better mental health outcomes among seafarers. Eroded policies related to crew changes had a significant negative effect on mental wellbeing due to delays caused by national quarantine guidelines and travel restrictions. The results also showed a discrepancy in mental health outcomes between those onboard and those onshore, with stress being present in both groups.\r\n\r\nThe findings suggest that crisis management within shipping companies played an important role in mitigating adverse mental health outcomes during the pandemic. Clear communication from employers and emphasizing safety issues onboard were effective strategies for promoting better mental wellbeing among seafarers. However, delays in crew changes had a significant negative impact on mental health outcomes, highlighting the need for global cooperation and overarching agreements to protect international seafarers during times of crises.", "doi": "10.1186/s12889-023-17035-2", "pmid": "37924109", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10623868"}, {"db": "pii", "key": "10.1186/s12889-023-17035-2"}], "notes": [], "created": "2023-12-04T07:21:24.874Z", "modified": "2023-12-07T12:34:43.630Z"}, {"entity": "publication", "iuid": "8d4eabeb7fae48c6b387e5f7c7769fd8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d4eabeb7fae48c6b387e5f7c7769fd8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d4eabeb7fae48c6b387e5f7c7769fd8"}}, "title": "Nosocomial SARS-CoV-2 Infections and Mortality During Unique COVID-19 Epidemic Waves.", "authors": [{"family": "Dave", "given": "Nishi", "initials": "N"}, {"family": "Sj\u00f6holm", "given": "Daniel", "initials": "D"}, {"family": "Hedberg", "given": "Pontus", "initials": "P"}, {"family": "Ternhag", "given": "Anders", "initials": "A"}, {"family": "Granath", "given": "Fredrik", "initials": "F"}, {"family": "Verberk", "given": "Janneke D M", "initials": "JDM"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}, {"family": "van der Werff", "given": "Suzanne D", "initials": "SD"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2023-11-01", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "issn-l": null, "volume": "6", "issue": "11", "pages": "e2341936"}, "abstract": "Quantifying the burden of nosocomial SARS-CoV-2 infections and associated mortality is necessary to assess the need for infection prevention and control measures.\r\n\r\nTo investigate the occurrence of nosocomial SARS-CoV-2 infections and associated 30-day mortality among patients admitted to hospitals in Region Stockholm, Sweden.\r\n\r\nA retrospective, matched cohort study divided the period from March 1, 2020, until September 15, 2022, into a prevaccination period, early vaccination and pre-Omicron (period 1), and late vaccination and Omicron (period 2). From among 303 898 patients 18 years or older living in Region Stockholm, 538 951 hospital admissions across all hospitals were included. Hospitalized admissions with nosocomial SARS-CoV-2 infections were matched to as many as 5 hospitalized admissions without nosocomial SARS-CoV-2 by age, sex, length of stay, admission time, and hospital unit.\r\n\r\nNosocomial SARS-CoV-2 infection defined as the first positive polymerase chain reaction test result at least 8 days after hospital admission or within 2 days after discharge.\r\n\r\nPrimary outcome of 30-day mortality was analyzed using time-to-event analyses with a Cox proportional hazards regression model adjusted for age, sex, educational level, and comorbidities.\r\n\r\nAmong 2193 patients with SARS-CoV-2 infections or reinfections (1107 women [50.5%]; median age, 80 [IQR, 71-87] years), 2203 nosocomial SARS-CoV-2 infections were identified. The incidence rate of nosocomial SARS-CoV-2 infections was 1.57 (95% CI, 1.51-1.64) per 1000 patient-days. In the matched cohort, 1487 hospital admissions with nosocomial SARS-CoV-2 infections were matched to 5044 hospital admissions without nosocomial SARS-CoV-2 infections. Thirty-day mortality was higher in the prevaccination period (adjusted hazard ratio [AHR], 2.97 [95% CI, 2.50-3.53]) compared with period 1 (AHR, 2.08 [95% CI, 1.50-2.88]) or period 2 (AHR, 1.22 [95% CI, 0.92-1.60]). Among patients with nosocomial SARS-CoV-2 infections, 30-day AHR comparing those with 2 or more doses of SARS-CoV-2 vaccination and those with less than 2 doses was 0.64 (95% CI, 0.46-0.88).\r\n\r\nIn this matched cohort study, nosocomial SARS-CoV-2 infections were associated with higher 30-day mortality during the early phases of the pandemic and lower mortality during the Omicron variant wave and after the introduction of vaccinations. Mitigation of excess mortality risk from nosocomial transmission should be a strong focus when population immunity is low through implementation of adequate infection prevention and control measures.", "doi": "10.1001/jamanetworkopen.2023.41936", "pmid": "37948082", "labels": {"Category: Health": null, "Type: Journal article": null, "Funder: VR": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10638644"}, {"db": "pii", "key": "2811647"}], "notes": [], "created": "2023-12-04T07:18:03.505Z", "modified": "2023-12-04T08:00:57.189Z"}, {"entity": "publication", "iuid": "1f41dfff404f4c829d233180306820c7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1f41dfff404f4c829d233180306820c7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1f41dfff404f4c829d233180306820c7"}}, "title": "Loneliness Trajectories, Associated Factors and Subsequent Health in Children and Young People During the COVID-19 Pandemic: A National Matched Cohort Study.", "authors": [{"family": "Schneider", "given": "Verena", "initials": "V", "orcid": "0000-0003-0244-6201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/044f9c1301d14599beed760c06e69ebb.json"}}, {"family": "Norris", "given": "Tom", "initials": "T", "orcid": "0000-0002-9140-0776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37e25921ecfc44f19b4de1857a860329.json"}}, {"family": "Nugawela", "given": "Manjula", "initials": "M", "orcid": "0000-0001-5989-9530", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be0b12176bca47aaa506a53fe7702e75.json"}}, {"family": "Dalrymple", "given": "Emma", "initials": "E", "orcid": "0000-0002-6645-932X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3434d84356e24469a672ca1239237238.json"}}, {"family": "Hargreaves", "given": "Dougal", "initials": "D", "orcid": "0000-0003-0722-9847", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5795067bbc194a058ed9bd25336eb088.json"}}, {"family": "K\u00e4ll", "given": "Anton", "initials": "A", "orcid": "0000-0003-1579-8791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/056530bccaae4fbcae0814472aa466a1.json"}}, {"family": "McOwat", "given": "Kelsey", "initials": "K", "orcid": "0000-0003-4170-1498", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b8be458eb274cc58cf5812871bc431b.json"}}, {"family": "Shafran", "given": "Roz", "initials": "R", "orcid": "0000-0003-2729-4961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aeaa53c5076542e893d1ab36c1cd84f2.json"}}, {"family": "Stephenson", "given": "Terence", "initials": "T", "orcid": "0000-0001-8871-7847", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f4906a81ff25438083c766dd2c87f122.json"}}, {"family": "Xu", "given": "Laila", "initials": "L"}, {"family": "Pinto Pereira", "given": "Snehal M", "initials": "SM", "orcid": "0000-0002-0876-8757", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/661bf07493be45519aa27ca074c99344.json"}}, {"family": "CLoCk Consortium members", "given": "", "initials": ""}], "type": "journal article", "published": "2023-11-01", "journal": {"title": "Psychol Res Behav Manag", "issn": "1179-1578", "issn-l": null, "volume": "16", "issue": null, "pages": "4461-4477"}, "abstract": "Loneliness is common amongst children and young people (CYP) and is an independent risk factor for poor health. This study aimed to i) determine whether subgroups of CYP with different loneliness trajectories (during the second year of the pandemic) exist; ii) examine associations with socio-demographic characteristics and subsequent health; and iii) understand whether associations between loneliness and subsequent health were modified by SARS-CoV-2 infection.\r\n\r\nA total of 5851 CYP (N=3260 SARS-CoV-2 positive and 2591 SARS-CoV-2 negative) provided data on loneliness (via the validated 3-item version of the UCLA Loneliness Scale for Children) at least twice in a 12-month period post PCR index-testing (conducted October 2020-March 2021). Latent class growth analyses were used to identify distinct classes of loneliness trajectories. Multinomial logistic regression was used to identify socio-demographic characteristics associated with class membership. Logistic regression models assessed the odds of reporting impairing symptoms 12-months post index-test.\r\n\r\nFour distinct loneliness trajectories were identified: three mostly stable (low, medium, high) and one low-increasing trajectory. Being older, female, living in more deprived areas and testing negative were associated with greater odds of being in the highest vs lowest loneliness trajectory; eg OR for female vs male: 5.6 (95% CI:4.1,7.8); OR for 15-17 vs 11-14 years: 4.5 (95% CI:3.4,6.0). Following higher loneliness trajectories was associated with higher odds of experiencing impairing symptoms 12-months post index-test: ORadjusted (compared to lowest loneliness trajectory) were 15.9 (95% CI:11.9,21.3) (high loneliness), 6.5 (5.3,7.9) (medium loneliness) and 2.3 (1.9,2.8) (low-increasing loneliness). There was no evidence that this association was modified by PCR index-test result.\r\n\r\nAbout 5.3% of CYP were classified into a group experiencing (chronically) high loneliness. Being female, older and from more deprived areas were risk factors of belonging to this group. Results suggest that even small increases from low loneliness levels may be associated with worse health outcomes.", "doi": "10.2147/PRBM.S421165", "pmid": "37936971", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10626032"}, {"db": "pii", "key": "421165"}], "notes": [], "created": "2023-12-04T07:22:10.992Z", "modified": "2023-12-08T06:07:57.553Z"}, {"entity": "publication", "iuid": "093f88c9ee8b4e2980059e4cf0f8929d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/093f88c9ee8b4e2980059e4cf0f8929d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/093f88c9ee8b4e2980059e4cf0f8929d"}}, "title": "Genetic Predisposition to Elevated Levels of Circulating ADAM17 Is Associated with the Risk of Severe COVID-19.", "authors": [{"family": "Pan", "given": "Mengyu", "initials": "M", "orcid": "0000-0002-9899-1345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25a523d6b90a43f8a223f4aa546dc5e4.json"}}, {"family": "Goncalves", "given": "Isabel", "initials": "I"}, {"family": "Edsfeldt", "given": "Andreas", "initials": "A"}, {"family": "Sun", "given": "Jiangming", "initials": "J", "orcid": "0000-0001-6814-1297", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0570b10fe3e246789bbbb07750afe598.json"}}, {"family": "Sw\u00e4rd", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2023-11-01", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "issn-l": null, "volume": "24", "issue": "21", "pages": null}, "abstract": "High levels of ADAM17 activity have emerged as an important mediator in severe COVID-19. This study aims to characterize eventual causal relationships between ADAM17 and COVID-19. Using Mendelian randomization analyses, we examined the causal effects of circulating ADAM17 on COVID-19 outcomes using summary statistics from large, genome-wide association studies of ADAM17 (up to 35,559 individuals) from the Icelandic Cancer Project and deCODE genetics, as well as critically ill COVID-19 patients (cases: 13,769; controls: 1,072,442), hospitalized COVID-19 patients (cases: 32,519; controls: 2,062,805) and reported SARS-CoV-2 infections (cases: 122,616; controls: 2,475,240) from the COVID-19 Host Genetics Initiative. The Mendelian randomization (MR) analyses demonstrated that a 1 standard deviation increase in genetically determined circulating ADAM17 (extracellular domain) was associated with an increased risk of developing critical ill COVID-19 (odds ratio [OR] = 1.26, 95% confidence interval [CI]:1.03-1.55). The multivariable MR analysis suggested a direct causal role of circulating ADAM17 (extracellular domain) in the risk of developing critical COVID-19 (OR = 1.09; 95% CI:1.01-1.17) when accounting for body mass index. No causal effect for the cytoplasmic domain of ADAM17 on COVID-19 was observed. Our results suggest that an increased genetic susceptibility to elevated levels of circulating ADAM17 (extracellular domain) is associated with a higher risk of suffering from severe COVID-19, strengthening the idea that the timely selective inhibition of ADAM17 could be a potential therapeutic target worthy of investigation.", "doi": "10.3390/ijms242115879", "pmid": "37958866", "labels": {"Funder: Hj\u00e4rt-Lungfonden": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10647461"}, {"db": "pii", "key": "ijms242115879"}], "notes": [], "created": "2023-12-04T07:16:35.951Z", "modified": "2023-12-04T07:24:33.921Z"}, {"entity": "publication", "iuid": "4c5e46159aca4fd68ded9ff2d3bdac4e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4c5e46159aca4fd68ded9ff2d3bdac4e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4c5e46159aca4fd68ded9ff2d3bdac4e"}}, "title": "Ex vivo challenge models for infectious diseases.", "authors": [{"family": "Gordhan", "given": "Bhavna Gowan", "initials": "BG"}, {"family": "Liebenberg", "given": "Dale", "initials": "D"}, {"family": "Scarlatti", "given": "Gabriella", "initials": "G"}, {"family": "Herrera", "given": "Carolina", "initials": "C"}, {"family": "Chiodi", "given": "Francesca", "initials": "F"}, {"family": "Martinson", "given": "Neil", "initials": "N"}, {"family": "Fox", "given": "Julie", "initials": "J"}, {"family": "Kana", "given": "Bavesh Davandra", "initials": "BD"}], "type": "journal article", "published": "2023-11-01", "journal": {"title": "Crit Rev Microbiol", "issn": "1549-7828", "issn-l": null, "volume": null, "issue": null, "pages": "1-20"}, "abstract": "Traditionally, molecular mechanisms of pathogenesis for infectious agents were studied in cell culture or animal models but have limitations on the extent to which the resulting data reflect natural infection in humans. The COVID-19 pandemic has highlighted the urgent need to rapidly develop laboratory models that enable the study of host-pathogen interactions, particularly the relative efficacy of preventive measures. Recently, human and animal ex vivo tissue challenge models have emerged as a promising avenue to study immune responses, screen potential therapies and triage vaccine candidates. This approach offers the opportunity to closely approximate human disease from the perspective of pathology and immune response. It has advantages compared to animal models which are expensive, lengthy and often require containment facilities. Herein, we summarize some recent advances in the development of ex vivo tissue challenge models for COVID-19, HIV-1 and other pathogens. We focus on the contribution of these models to enhancing knowledge of host-pathogen interactions, immune modulation, and their value in testing therapeutic agents. We further highlight the advantages and limitations of using ex vivo challenge models and briefly summarize how the use of organoids provides a useful advancement over current approaches. Collectively, these developments have enormous potential for the study of infectious diseases.", "doi": "10.1080/1040841X.2023.2274855", "pmid": "37909097", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-12-04T07:21:47.516Z", "modified": "2023-12-08T05:58:25.875Z"}, {"entity": "publication", "iuid": "ec9e9c6f93e74567bb6a685721a75efb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec9e9c6f93e74567bb6a685721a75efb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec9e9c6f93e74567bb6a685721a75efb"}}, "title": "Vaccine effectiveness against COVID-19 hospitalisation in adults (\u2265 20 years) during Omicron-dominant circulation: I-MOVE-COVID-19 and VEBIS SARI VE networks, Europe, 2021 to 2022.", "authors": [{"family": "Rose", "given": "Angela Mc", "initials": "AM"}, {"family": "Nicolay", "given": "Nathalie", "initials": "N"}, {"family": "Sandonis Mart\u00edn", "given": "Virginia", "initials": "V"}, {"family": "Mazagatos", "given": "Clara", "initials": "C"}, {"family": "Petrovi\u0107", "given": "Goranka", "initials": "G"}, {"family": "Baruch", "given": "Joaquin", "initials": "J"}, {"family": "Denayer", "given": "Sarah", "initials": "S"}, {"family": "Seyler", "given": "Lucie", "initials": "L"}, {"family": "Domegan", "given": "Lisa", "initials": "L"}, {"family": "Launay", "given": "Odile", "initials": "O"}, {"family": "Machado", "given": "Ausenda", "initials": "A"}, {"family": "Burgui", "given": "Cristina", "initials": "C"}, {"family": "Vaikutyte", "given": "Roberta", "initials": "R"}, {"family": "Niessen", "given": "F Annabel", "initials": "FA"}, {"family": "Loghin", "given": "Isabela I", "initials": "II"}, {"family": "Husa", "given": "Petr", "initials": "P"}, {"family": "Aouali", "given": "Nassera", "initials": "N"}, {"family": "Panagiotakopoulos", "given": "George", "initials": "G"}, {"family": "Tolksdorf", "given": "Kristin", "initials": "K"}, {"family": "Horv\u00e1th", "given": "Judit Krisztina", "initials": "JK"}, {"family": "Howard", "given": "Jennifer", "initials": "J"}, {"family": "Pozo", "given": "Francisco", "initials": "F"}, {"family": "Gallardo", "given": "Virtudes", "initials": "V"}, {"family": "Nonkovi\u0107", "given": "Diana", "initials": "D"}, {"family": "D\u017eiugyt\u0117", "given": "Au\u0161ra", "initials": "A"}, {"family": "Bossuyt", "given": "Nathalie", "initials": "N"}, {"family": "Demuyser", "given": "Thomas", "initials": "T"}, {"family": "Duffy", "given": "R\u00f3is\u00edn", "initials": "R"}, {"family": "Luong Nguyen", "given": "Liem Binh", "initials": "LB"}, {"family": "Kislaya", "given": "Irina", "initials": "I"}, {"family": "Mart\u00ednez-Baz", "given": "Iv\u00e1n", "initials": "I"}, {"family": "Gefenaite", "given": "Giedre", "initials": "G"}, {"family": "Knol", "given": "Mirjam J", "initials": "MJ"}, {"family": "Popescu", "given": "Corneliu", "initials": "C"}, {"family": "Sou\u010dkov\u00e1", "given": "Lenka", "initials": "L"}, {"family": "Simon", "given": "Marc", "initials": "M"}, {"family": "Michelaki", "given": "Stella", "initials": "S"}, {"family": "Reiche", "given": "Janine", "initials": "J"}, {"family": "Ferenczi", "given": "Annam\u00e1ria", "initials": "A"}, {"family": "Delgado-Sanz", "given": "Concepci\u00f3n", "initials": "C"}, {"family": "Lovri\u0107 Makari\u0107", "given": "Zvjezdana", "initials": "Z"}, {"family": "Cauchi", "given": "John Paul", "initials": "JP"}, {"family": "Barbezange", "given": "Cyril", "initials": "C"}, {"family": "Van Nedervelde", "given": "Els", "initials": "E"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}, {"family": "Durier", "given": "Christine", "initials": "C"}, {"family": "Guiomar", "given": "Raquel", "initials": "R"}, {"family": "Castilla", "given": "Jes\u00fas", "initials": "J"}, {"family": "Jonikaite", "given": "Indr\u0117", "initials": "I"}, {"family": "Bruijning-Verhagen", "given": "Patricia Cjl", "initials": "PC"}, {"family": "Lazar", "given": "Mihaela", "initials": "M"}, {"family": "Demlov\u00e1", "given": "Regina", "initials": "R"}, {"family": "Wirtz", "given": "Gil", "initials": "G"}, {"family": "Amerali", "given": "Marina", "initials": "M"}, {"family": "D\u00fcrrwald", "given": "Ralf", "initials": "R"}, {"family": "Kunst\u00e1r", "given": "Mih\u00e1ly P\u00e1l", "initials": "MP"}, {"family": "Kissling", "given": "Esther", "initials": "E"}, {"family": "Bacci", "given": "Sabrina", "initials": "S"}, {"family": "Valenciano", "given": "Marta", "initials": "M"}, {"family": "I-MOVE-COVID-19 hospital study team", "given": "", "initials": ""}, {"family": "VEBIS hospital study team", "given": "", "initials": ""}, {"family": "Members of the I-MOVE-COVID-19 and VEBIS hospital study teams (in addition to authors above)", "given": "", "initials": ""}], "type": "journal article", "published": "2023-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "47", "pages": null}, "abstract": "IntroductionThe I-MOVE-COVID-19 and VEBIS hospital networks have been measuring COVID-19 vaccine effectiveness (VE) in participating European countries since early 2021.AimWe aimed to measure VE against PCR-confirmed SARS-CoV-2 in patients \u2265 20 years hospitalised with severe acute respiratory infection (SARI) from December 2021 to July 2022 (Omicron-dominant period).MethodsIn both networks, 46 hospitals (13 countries) follow a similar test-negative case-control protocol. We defined complete primary series vaccination (PSV) and first booster dose vaccination as last dose of either vaccine received \u2265 14 days before symptom onset (stratifying first booster into received < 150 and \u2265 150 days after last PSV dose). We measured VE overall, by vaccine category/product, age group and time since first mRNA booster dose, adjusting by site as a fixed effect, and by swab date, age, sex, and presence/absence of at least one commonly collected chronic condition.ResultsWe included 2,779 cases and 2,362 controls. The VE of all vaccine products combined against hospitalisation for laboratory-confirmed SARS-CoV-2 was 43% (95% CI: 29-54) for complete PSV (with last dose received \u2265 150 days before onset), while it was 59% (95% CI: 51-66) after addition of one booster dose. The VE was 85% (95% CI: 78-89), 70% (95% CI: 61-77) and 36% (95% CI: 17-51) for those with onset 14-59 days, 60-119 days and 120-179 days after booster vaccination, respectively.ConclusionsOur results suggest that, during the Omicron period, observed VE against SARI hospitalisation improved with first mRNA booster dose, particularly for those having symptom onset < 120 days after first booster dose.", "doi": "10.2807/1560-7917.ES.2023.28.47.2300187", "pmid": "37997665", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10668256"}], "notes": [], "created": "2023-12-04T07:17:13.309Z", "modified": "2023-12-04T07:41:40.798Z"}, {"entity": "publication", "iuid": "864b860018f943aea0f61b7bec41c223", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/864b860018f943aea0f61b7bec41c223.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/864b860018f943aea0f61b7bec41c223"}}, "title": "Vaccine effectiveness against COVID-19 hospitalisation in adults (\u2265 20 years) during Alpha- and Delta-dominant circulation: I-MOVE-COVID-19 and VEBIS SARI VE networks, Europe, 2021.", "authors": [{"family": "Rose", "given": "Angela Mc", "initials": "AM"}, {"family": "Nicolay", "given": "Nathalie", "initials": "N"}, {"family": "Sandonis Mart\u00edn", "given": "Virginia", "initials": "V"}, {"family": "Mazagatos", "given": "Clara", "initials": "C"}, {"family": "Petrovi\u0107", "given": "Goranka", "initials": "G"}, {"family": "Niessen", "given": "F Annabel", "initials": "FA"}, {"family": "Machado", "given": "Ausenda", "initials": "A"}, {"family": "Launay", "given": "Odile", "initials": "O"}, {"family": "Denayer", "given": "Sarah", "initials": "S"}, {"family": "Seyler", "given": "Lucie", "initials": "L"}, {"family": "Baruch", "given": "Joaquin", "initials": "J"}, {"family": "Burgui", "given": "Cristina", "initials": "C"}, {"family": "Loghin", "given": "Isabela I", "initials": "II"}, {"family": "Domegan", "given": "Lisa", "initials": "L"}, {"family": "Vaikutyt\u0117", "given": "Roberta", "initials": "R"}, {"family": "Husa", "given": "Petr", "initials": "P"}, {"family": "Panagiotakopoulos", "given": "George", "initials": "G"}, {"family": "Aouali", "given": "Nassera", "initials": "N"}, {"family": "D\u00fcrrwald", "given": "Ralf", "initials": "R"}, {"family": "Howard", "given": "Jennifer", "initials": "J"}, {"family": "Pozo", "given": "Francisco", "initials": "F"}, {"family": "Sastre-Palou", "given": "Bartolom\u00e9", "initials": "B"}, {"family": "Nonkovi\u0107", "given": "Diana", "initials": "D"}, {"family": "Knol", "given": "Mirjam J", "initials": "MJ"}, {"family": "Kislaya", "given": "Irina", "initials": "I"}, {"family": "Luong Nguyen", "given": "Liem Binh", "initials": "LB"}, {"family": "Bossuyt", "given": "Nathalie", "initials": "N"}, {"family": "Demuyser", "given": "Thomas", "initials": "T"}, {"family": "D\u017eiugyt\u0117", "given": "Au\u0161ra", "initials": "A"}, {"family": "Mart\u00ednez-Baz", "given": "Iv\u00e1n", "initials": "I"}, {"family": "Popescu", "given": "Corneliu", "initials": "C"}, {"family": "Duffy", "given": "R\u00f3is\u00edn", "initials": "R"}, {"family": "Kulie\u0161\u0117", "given": "Monika", "initials": "M"}, {"family": "Sou\u010dkov\u00e1", "given": "Lenka", "initials": "L"}, {"family": "Michelaki", "given": "Stella", "initials": "S"}, {"family": "Simon", "given": "Marc", "initials": "M"}, {"family": "Reiche", "given": "Janine", "initials": "J"}, {"family": "Otero-Barr\u00f3s", "given": "Mar\u00eda Teresa", "initials": "MT"}, {"family": "Lovri\u0107 Makari\u0107", "given": "Zvjezdana", "initials": "Z"}, {"family": "Bruijning-Verhagen", "given": "Patricia Cjl", "initials": "PC"}, {"family": "Gomez", "given": "Ver\u00f3nica", "initials": "V"}, {"family": "Lesieur", "given": "Zineb", "initials": "Z"}, {"family": "Barbezange", "given": "Cyril", "initials": "C"}, {"family": "Van Nedervelde", "given": "Els", "initials": "E"}, {"family": "Borg", "given": "Maria-Louise", "initials": "M"}, {"family": "Castilla", "given": "Jes\u00fas", "initials": "J"}, {"family": "Lazar", "given": "Mihaela", "initials": "M"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}, {"family": "Jonikait\u0117", "given": "Indr\u0117", "initials": "I"}, {"family": "Demlov\u00e1", "given": "Regina", "initials": "R"}, {"family": "Amerali", "given": "Marina", "initials": "M"}, {"family": "Wirtz", "given": "Gil", "initials": "G"}, {"family": "Tolksdorf", "given": "Kristin", "initials": "K"}, {"family": "Valenciano", "given": "Marta", "initials": "M"}, {"family": "Bacci", "given": "Sabrina", "initials": "S"}, {"family": "Kissling", "given": "Esther", "initials": "E"}, {"family": "I-MOVE-COVID-19 hospital study team", "given": "", "initials": ""}, {"family": "VEBIS hospital study team", "given": "", "initials": ""}, {"family": "Members of the I-MOVE-COVID-19 and VEBIS hospital study teams (in addition to the named authors)", "given": "", "initials": ""}], "type": "journal article", "published": "2023-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "47", "pages": null}, "abstract": "IntroductionTwo large multicentre European hospital networks have estimated vaccine effectiveness (VE) against COVID-19 since 2021.AimWe aimed to measure VE against PCR-confirmed SARS-CoV-2 in hospitalised severe acute respiratory illness (SARI) patients \u2265 20 years, combining data from these networks during Alpha (March-June)- and Delta (June-December)-dominant periods, 2021.MethodsForty-six participating hospitals across 14 countries follow a similar generic protocol using the test-negative case-control design. We defined complete primary series vaccination (PSV) as two doses of a two-dose or one of a single-dose vaccine \u2265 14 days before onset.ResultsWe included 1,087 cases (538 controls) and 1,669 cases (1,442 controls) in the Alpha- and Delta-dominant periods, respectively. During the Alpha period, VE against hospitalisation with SARS-CoV2 for complete Comirnaty PSV was 85% (95% CI: 69-92) overall and 75% (95% CI: 42-90) in those aged \u2265 80 years. During the Delta period, among SARI patients \u2265 20 years with symptom onset \u2265 150 days from last PSV dose, VE for complete Comirnaty PSV was 54% (95% CI: 18-74). Among those receiving Comirnaty PSV and mRNA booster (any product) \u2265 150 days after last PSV dose, VE was 91% (95% CI: 57-98). In time-since-vaccination analysis, complete all-product PSV VE was > 90% in those with their last dose < 90 days before onset; \u2265 70% in those 90-179 days before onset.ConclusionsOur results from this EU multi-country hospital setting showed that VE for complete PSV alone was higher in the Alpha- than the Delta-dominant period, and addition of a first booster dose during the latter period increased VE to over 90%.", "doi": "10.2807/1560-7917.ES.2023.28.47.2300186", "pmid": "37997666", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10668259"}], "notes": [], "created": "2023-12-04T07:21:45.009Z", "modified": "2023-12-08T05:56:51.779Z"}, {"entity": "publication", "iuid": "0b40ee94b7b14b458eb231e8a2746373", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b40ee94b7b14b458eb231e8a2746373.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b40ee94b7b14b458eb231e8a2746373"}}, "title": "Safety, tolerability, and pharmacokinetics of half-life extended SARS-CoV-2-neutralizing monoclonal antibodies AZD7442 (tixagevimab/cilgavimab) in healthy Japanese adults.", "authors": [{"family": "Okada", "given": "Hiroshi", "initials": "H"}, {"family": "Ishikawa", "given": "Kensuke", "initials": "K"}, {"family": "Itoh", "given": "Yohji", "initials": "Y"}, {"family": "Noda", "given": "Yoshinori", "initials": "Y"}, {"family": "Eto", "given": "Takashi", "initials": "T"}, {"family": "Pilla Reddy", "given": "Venkatesh", "initials": "V"}, {"family": "Chen", "given": "Cecil Chi-Keung", "initials": "CC"}, {"family": "Gibbs", "given": "Michael", "initials": "M"}, {"family": "Johnsson", "given": "Eva", "initials": "E"}], "type": "randomized controlled trial", "published": "2023-11-00", "journal": {"title": "J Infect Chemother", "issn": "1437-7780", "issn-l": null, "volume": "29", "issue": "11", "pages": "1061-1067"}, "abstract": "The aim of this study was to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of AZD7442 (tixagevimab/cilgavimab) in healthy Japanese adults.\r\n\r\nIn this randomized, double-blind, placebo-controlled, phase 1 study, AZD7442 was administered intramuscularly (300 or 600 mg) or intravenously (300 or 1000 mg) to healthy Japanese adults. Primary endpoints were safety, tolerability, and pharmacokinetics. Anti-drug antibodies and neutralizing antibody activities were secondary endpoints.\r\n\r\nA total of 40 participants were randomized to receive AZD7442 (n = 30) or placebo (n = 10). Adverse events (AEs) occurred in 12 (40%) and 3 (30%) participants, respectively; there were no deaths, serious AEs, or AEs leading to study withdrawal. Tixagevimab and cilgavimab had mean half-lives of 82.1-95.9 and 77.9-92.0 days, respectively, which were generally similar regardless of administration route. SARS-CoV-2-neutralizing antibody titers were >4-fold higher than baseline levels from Day 8 to Day 211 in participants receiving AZD7442.\r\n\r\nAZD7442 was well tolerated in healthy Japanese adults, with predictable pharmacokinetics and an extended half-life, consistent with previous studies.\r\n\r\ngov, NCT04896541.", "doi": "10.1016/j.jiac.2023.07.014", "pmid": "37524201", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S1341-321X(23)00181-2"}, {"db": "ClinicalTrials.gov", "key": "NCT04896541"}], "notes": [], "created": "2023-10-05T08:27:04.847Z", "modified": "2023-10-06T05:19:49.899Z"}, {"entity": "publication", "iuid": "339a8a417ff74f17b13b58cd0fbf613f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/339a8a417ff74f17b13b58cd0fbf613f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/339a8a417ff74f17b13b58cd0fbf613f"}}, "title": "Rebound in community antibiotic consumption after the observed decrease during the COVID-19 pandemic, EU/EEA, 2022.", "authors": [{"family": "Ventura-Gabarr\u00f3", "given": "C\u00e8lia", "initials": "C"}, {"family": "Leung", "given": "Vivian H", "initials": "VH"}, {"family": "Vlahovi\u0107-Pal\u010devski", "given": "Vera", "initials": "V"}, {"family": "Machowska", "given": "Anna", "initials": "A"}, {"family": "Monnet", "given": "Dominique L", "initials": "DL"}, {"family": "H\u00f6gberg", "given": "Liselotte Diaz", "initials": "LD"}, {"family": "ESAC-Net study group", "given": "", "initials": ""}, {"family": "ESAC-Net study group participants", "given": "", "initials": ""}], "type": "journal article", "published": "2023-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "46", "pages": null}, "abstract": "We observed a rebound in consumption of antibacterials for systemic use (ATC J01) in the community sector in the European Union/European Economic Area during 2021 and 2022, after an observed decrease between 2019 and 2020. The rates in 2022 returned to pre-COVID-19-pandemic levels and were exceeded in 13 countries. Although these patterns could partly be a result of changes in disease transmission during the study period, it could also reflect a lost opportunity to strengthen and reinforce prudent antibiotic use.", "doi": "10.2807/1560-7917.ES.2023.28.46.2300604", "pmid": "37971660", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10655206"}], "notes": [], "created": "2023-12-04T07:21:27.291Z", "modified": "2023-12-07T12:36:31.985Z"}, {"entity": "publication", "iuid": "3b1550b3072e4388b2abda49ad05e774", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b1550b3072e4388b2abda49ad05e774.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b1550b3072e4388b2abda49ad05e774"}}, "title": "Monoclonal antibodies lock down SARS-CoV-2 spike.", "authors": [{"family": "Huang", "given": "Hsiang-Chi", "initials": "H"}, {"family": "Angeletti", "given": "Davide", "initials": "D"}], "type": "journal article", "published": "2023-11-00", "journal": {"title": "Trends Immunol", "issn": "1471-4981", "issn-l": null, "volume": "44", "issue": "11", "pages": "874-876"}, "abstract": "SARS-CoV-2 rapidly accumulated mutations in its immunodominant receptor-binding domain (RBD), rendering all clinically authorized monoclonal antibodies (mAbs) ineffective. Liu et al. unveil potent human mAbs that neutralize all tested SARS-CoV-2 variants by locking the Spike protein RBD in a downward conformation, thus inhibiting receptor engagement.", "doi": "10.1016/j.it.2023.09.006", "pmid": "37805348", "labels": {"Category: Vaccines": null, "Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1471-4906(23)00202-8"}], "notes": [], "created": "2023-11-01T13:33:13.225Z", "modified": "2023-11-02T07:15:29.144Z"}, {"entity": "publication", "iuid": "6402deb933b348e88b52c62ce13b40c2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6402deb933b348e88b52c62ce13b40c2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6402deb933b348e88b52c62ce13b40c2"}}, "title": "Monitoring COVID-19 vaccine effectiveness against COVID-19 hospitalisation and death using electronic health registries in \u226565 years old population in six European countries, October 2021 to November 2022.", "authors": [{"family": "Kislaya", "given": "Irina", "initials": "I", "orcid": "0000-0001-5772-2416", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75dec9255ced430ea7ec07f05d0f9bd2.json"}}, {"family": "Sent\u00eds", "given": "Alexis", "initials": "A"}, {"family": "Starrfelt", "given": "Jostein", "initials": "J"}, {"family": "Nunes", "given": "Baltazar", "initials": "B"}, {"family": "Mart\u00ednez-Baz", "given": "Iv\u00e1n", "initials": "I"}, {"family": "Nielsen", "given": "Katrine Finderup", "initials": "KF"}, {"family": "AlKerwi", "given": "Ala'a", "initials": "A"}, {"family": "Braeye", "given": "Toon", "initials": "T"}, {"family": "Font\u00e1n-Vela", "given": "Mario", "initials": "M"}, {"family": "Bacci", "given": "Sabrina", "initials": "S"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}, {"family": "Castilla", "given": "Jes\u00fas", "initials": "J", "orcid": "0000-0002-6396-7265", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/737423cde32943e7b14111322dd4a748.json"}}, {"family": "Emborg", "given": "Hanne-Dorthe", "initials": "H"}, {"family": "Hansen", "given": "Christian Holm", "initials": "CH"}, {"family": "Schmitz", "given": "Susanne", "initials": "S"}, {"family": "Van Evercooren", "given": "Izaak", "initials": "I"}, {"family": "Valenciano", "given": "Marta", "initials": "M"}, {"family": "Nardone", "given": "Anthony", "initials": "A"}, {"family": "Nicolay", "given": "Nathalie", "initials": "N"}, {"family": "Monge", "given": "Susana", "initials": "S", "orcid": "0000-0003-1412-3012", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/845f304853994ba4a7481c293fff05df.json"}}, {"family": "VEBIS-Lot4 working group", "given": "", "initials": ""}], "type": "meta-analysis", "published": "2023-11-00", "journal": {"title": "Influenza Other Respir Viruses", "issn": "1750-2659", "issn-l": null, "volume": "17", "issue": "11", "pages": "e13195"}, "abstract": "Within the ECDC-VEBIS project, we prospectively monitored vaccine effectiveness (VE) against COVID-19 hospitalisation and COVID-19-related death using electronic health registries (EHR), between October 2021 and November 2022, in community-dwelling residents aged 65-79 and \u226580 years in six European countries.\r\n\r\nEHR linkage was used to construct population cohorts in Belgium, Denmark, Luxembourg, Navarre (Spain), Norway and Portugal. Using a common protocol, for each outcome, VE was estimated monthly over 8-week follow-up periods, allowing 1 month-lag for data consolidation. Cox proportional-hazards models were used to estimate adjusted hazard ratios (aHR) and VE = (1 - aHR) \u00d7 100%. Site-specific estimates were pooled using random-effects meta-analysis.\r\n\r\nFor \u226580 years, considering unvaccinated as the reference, VE against COVID-19 hospitalisation decreased from 66.9% (95% CI: 60.1; 72.6) to 36.1% (95% CI: -27.3; 67.9) for the primary vaccination and from 95.6% (95% CI: 88.0; 98.4) to 67.7% (95% CI: 45.9; 80.8) for the first booster. Similar trends were observed for 65-79 years. The second booster VE against hospitalisation ranged between 82.0% (95% CI: 75.9; 87.0) and 83.9% (95% CI: 77.7; 88.4) for the \u226580 years and between 39.3% (95% CI: -3.9; 64.5) and 80.6% (95% CI: 67.2; 88.5) for 65-79 years. The first booster VE against COVID-19-related death declined over time for both age groups, while the second booster VE against death remained above 80% for the \u226580 years.\r\n\r\nSuccessive vaccine boosters played a relevant role in maintaining protection against COVID-19 hospitalisation and death, in the context of decreasing VE over time. Multicountry data from EHR facilitate robust near-real-time VE monitoring in the EU/EEA and support public health decision-making.", "doi": "10.1111/irv.13195", "pmid": "38019704", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10682901"}], "notes": [], "created": "2023-12-04T07:21:07.954Z", "modified": "2023-12-04T08:12:04.134Z"}, {"entity": "publication", "iuid": "ab1d5e909397484d9242436e0c5a6ce9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ab1d5e909397484d9242436e0c5a6ce9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ab1d5e909397484d9242436e0c5a6ce9"}}, "title": "Hospital care for critical illness in low-resource settings: lessons learned during the COVID-19 pandemic.", "authors": [{"family": "English", "given": "Mike", "initials": "M", "orcid": "0000-0002-7427-0826", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d680cdafc8854a619f1919652dd16aed.json"}}, {"family": "Oliwa", "given": "Jacquie", "initials": "J"}, {"family": "Khalid", "given": "Karima", "initials": "K"}, {"family": "Onyango", "given": "Onesmus", "initials": "O"}, {"family": "Willows", "given": "Tamara Mulenga", "initials": "TM", "orcid": "0000-0003-0760-5574", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a81a219f7e1647789a38f3bdfd754b16.json"}}, {"family": "Mazhar", "given": "Rosanna", "initials": "R"}, {"family": "Mkumbo", "given": "Elibariki", "initials": "E"}, {"family": "Guinness", "given": "Lorna", "initials": "L", "orcid": "0000-0002-1013-4200", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bf8da5dd3e24b669b1f58ea651be77a.json"}}, {"family": "Schell", "given": "Carl Otto", "initials": "CO", "orcid": "0000-0002-7904-1336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a40b337b45b471d97a102c355c9d874.json"}}, {"family": "Baker", "given": "Tim", "initials": "T", "orcid": "0000-0001-8727-7018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1454fc20049b4d47865268adf16d104a.json"}}, {"family": "McKnight", "given": "Jacob", "initials": "J", "orcid": "0000-0003-1340-2618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ab57e6a797048338416851ae43170a9.json"}}], "type": "journal article", "published": "2023-11-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "issn-l": "2059-7908", "volume": "8", "issue": "11", "pages": null}, "abstract": "Care for the critically ill patients is often considered synonymous with a hospital having an intensive care unit. However, a focus on Essential Emergency and Critical Care (EECC) may obviate the need for much intensive care. Severe COVID-19 presented a specific critical care challenge while also being an exemplar of critical illness in general. Our multidisciplinary team conducted research in Kenya and Tanzania on hospitals' ability to provide EECC as the COVID-19 pandemic unfolded. Important basic inputs were often lacking, especially sufficient numbers of skilled health workers. However, we learnt that higher scores on resource readiness scales were often misleading, as resources were often insufficient or not functional in all the clinical areas they are needed. By following patient journeys, through interviews and group discussions, we revealed gaps in timeliness, continuity and delivery of care. Generic challenges in transitions between departments were identified in the receipt of critically ill patients, the ability to sustain monitoring and treatment and preparation for any subsequent transition. While the global response to COVID-19 focused initially on providing technologies and training, first ventilators and later oxygen, organisational and procedural challenges seemed largely ignored. Yet, they may even be exacerbated by new technologies. Efforts to improve care for the critically ill patients, which is a complex process, must include a whole system and whole facility view spanning all areas of patients' care and their transitions and not be focused on a single location providing 'critical care'. We propose a five-part strategy to support the system changes needed.", "doi": "10.1136/bmjgh-2023-013407", "pmid": "37918869", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10626868"}, {"db": "pii", "key": "bmjgh-2023-013407"}], "notes": [], "created": "2023-12-04T07:18:14.255Z", "modified": "2023-12-04T08:06:12.076Z"}, {"entity": "publication", "iuid": "3fb31ed288224780a8e23fa69b3793e5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3fb31ed288224780a8e23fa69b3793e5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3fb31ed288224780a8e23fa69b3793e5"}}, "title": "Early detection of the emerging SARS-CoV-2 BA.2.86 lineage through integrated genomic surveillance of wastewater and COVID-19 cases in Sweden, weeks 31 to 38 2023.", "authors": [{"family": "Espinosa-Gongora", "given": "Carmen", "initials": "C"}, {"family": "Berg", "given": "Carlo", "initials": "C"}, {"family": "Rehn", "given": "Moa", "initials": "M"}, {"family": "Varg", "given": "Javier Edo", "initials": "JE"}, {"family": "Dillner", "given": "Lena", "initials": "L"}, {"family": "Latorre-Margalef", "given": "Neus", "initials": "N"}, {"family": "Sz\u00e9kely", "given": "Anna J", "initials": "AJ"}, {"family": "Andersson", "given": "Emmi", "initials": "E"}, {"family": "Movert", "given": "Elin", "initials": "E"}], "type": "journal article", "published": "2023-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "46", "pages": null}, "abstract": "The SARS-CoV-2 BA.2.86 Omicron subvariant was first detected in wastewater in Sweden in week 31 2023, using 21 highly specific markers from the 50 investigated. We report BA.2.86's introduction and subsequent spread to all 14 regions performing wastewater sampling, and on 70 confirmed COVID-19 cases, along with the emergence of sublineages JN.1 and JN.2. Further, we investigated two novel mutations defining the unique BA.2.86 branching in Sweden. Our integrated approach enabled variant tracking, offering evidence for well-informed public health interventions.", "doi": "10.2807/1560-7917.ES.2023.28.46.2300595", "pmid": "37971659", "labels": {"Category: Genomics & transcriptomics": null, "Category: Other": null, "Type: Journal article": null, "Funder: VR": null, "Research Area: Environmental virus profiling": null}, "xrefs": [{"db": "pmc", "key": "PMC10655203"}], "notes": [], "created": "2023-12-04T07:16:45.113Z", "modified": "2023-12-04T07:29:26.411Z"}, {"entity": "publication", "iuid": "fff3a02de3024a11a9d52d9ce733906e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fff3a02de3024a11a9d52d9ce733906e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fff3a02de3024a11a9d52d9ce733906e"}}, "title": "Chronic Candida albicans meningitis following critical COVID-19 and serial measurements of (1,3)-\u03b2-D-glucan in cerebrospinal fluid.", "authors": [{"family": "Andreen", "given": "Niklas", "initials": "N"}, {"family": "Brink", "given": "Magnus", "initials": "M"}, {"family": "Hammarstr\u00f6m", "given": "Helena", "initials": "H"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}], "type": "journal article", "published": "2023-11-00", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": "55", "issue": "11", "pages": "794-797"}, "abstract": "Co-infections with invasive candidiasis have been reported to be overrepresented in severe COVID-19. This report presents an unusual case of chronic Candida meningitis following intensive care for COVID-19.", "doi": "10.1080/23744235.2023.2232448", "pmid": "37427429", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Serology": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:08:45.050Z", "modified": "2023-10-04T12:40:11.993Z"}, {"entity": "publication", "iuid": "5c45ab59c680434aad60e81c6c0f1449", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c45ab59c680434aad60e81c6c0f1449.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c45ab59c680434aad60e81c6c0f1449"}}, "title": "COVID-19 vaccination acceptance, safety and side-effects in European patients with severe asthma.", "authors": [{"family": "Bossios", "given": "Apostolos", "initials": "A", "orcid": "0000-0002-0494-2690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/494bc3af38b0417186d9444f1ee3fa97.json"}}, {"family": "Bacon", "given": "Alison M", "initials": "AM", "orcid": "0000-0003-4279-3814", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b6040010eb24885832dc5ed684e7cfc.json"}}, {"family": "Eger", "given": "Katrien", "initials": "K", "orcid": "0000-0002-9628-2174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ec87651e0164ace9872a7186867fa83.json"}}, {"family": "Par\u00f3czai", "given": "D\u00f3ra", "initials": "D"}, {"family": "Schleich", "given": "Florence", "initials": "F", "orcid": "0000-0002-2678-1373", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d65afdf9b1c44cc9d8494084b549f65.json"}}, {"family": "Hanon", "given": "Shane", "initials": "S", "orcid": "0000-0002-1413-7927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7982834fd3b3482e941c666c75273f84.json"}}, {"family": "Sergejeva", "given": "Svetlana", "initials": "S"}, {"family": "Zervas", "given": "Eleftherios", "initials": "E", "orcid": "0000-0001-7436-4550", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0d338ea2b724ccab920b95ae3c42ffe.json"}}, {"family": "Katsoulis", "given": "Konstantinos", "initials": "K"}, {"family": "Aggelopoulou", "given": "Christina", "initials": "C"}, {"family": "Kostikas", "given": "Konstantinos", "initials": "K", "orcid": "0000-0003-0774-3942", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3eaa831d14b14f5e9188d8f05ede185f.json"}}, {"family": "Gaki", "given": "Eleni", "initials": "E"}, {"family": "Rovina", "given": "Nikoletta", "initials": "N"}, {"family": "Csoma", "given": "Zsuzsanna", "initials": "Z"}, {"family": "Grisle", "given": "Ineta", "initials": "I"}, {"family": "Bieksien\u00e9", "given": "Kristina", "initials": "K"}, {"family": "Palacionyte", "given": "Jolita", "initials": "J"}, {"family": "Ten Brinke", "given": "Anneke", "initials": "A"}, {"family": "Hashimoto", "given": "Simone", "initials": "S", "orcid": "0000-0001-8995-3817", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5d3f0acc6674d52bd765e2c0e58f4e1.json"}}, {"family": "Mih\u0103l\u0163an", "given": "Florin", "initials": "F"}, {"family": "Nenasheva", "given": "Natalia", "initials": "N"}, {"family": "Zvezdin", "given": "Biljana", "initials": "B"}, {"family": "\u010cekerevac", "given": "Ivan", "initials": "I"}, {"family": "Hromi\u0161", "given": "Sanja", "initials": "S", "orcid": "0000-0001-6132-1551", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cde21159f74b44be997d9a86750758ec.json"}}, {"family": "\u0106upurdija", "given": "Vojislav", "initials": "V"}, {"family": "Lazic", "given": "Zorica", "initials": "Z"}, {"family": "Chaudhuri", "given": "Rekha", "initials": "R"}, {"family": "Smith", "given": "Steven James", "initials": "SJ"}, {"family": "Rupani", "given": "Hitasha", "initials": "H", "orcid": "0000-0002-0150-138X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72a59c1e6c084f38802075b877b280d1.json"}}, {"family": "Haitchi", "given": "Hans Michael", "initials": "HM", "orcid": "0000-0001-8603-302X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6de760fa29414bf399a0a03e50ddc057.json"}}, {"family": "Kurukulaaratchy", "given": "Ramesh", "initials": "R"}, {"family": "Fulton", "given": "Olivia", "initials": "O", "orcid": "0000-0001-7358-0219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/707e706c3f8149e4aa9a8009017d0028.json"}}, {"family": "Frankem\u00f6lle", "given": "Betty", "initials": "B"}, {"family": "Howarth", "given": "Peter", "initials": "P", "orcid": "0000-0003-0619-7927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ac4536cccd642efa26db94364dceac2.json"}}, {"family": "Porsbjerg", "given": "Celeste", "initials": "C"}, {"family": "Bel", "given": "Elisabeth H", "initials": "EH"}, {"family": "Djukanovic", "given": "Ratko", "initials": "R"}, {"family": "Hyland", "given": "Michael E", "initials": "ME"}], "type": "journal article", "published": "2023-11-00", "journal": {"title": "ERJ Open Res", "issn": "2312-0541", "issn-l": null, "volume": "9", "issue": "6", "pages": null}, "abstract": "Vaccination is vital for achieving population immunity to severe acute respiratory syndrome coronavirus 2, but vaccination hesitancy presents a threat to achieving widespread immunity. Vaccine acceptance in chronic potentially immunosuppressed patients is largely unclear, especially in patients with asthma. The aim of this study was to investigate the vaccination experience in people with severe asthma.\r\n\r\nQuestionnaires about vaccination beliefs (including the Vaccination Attitudes Examination (VAX) scale, a measure of vaccination hesitancy-related beliefs), vaccination side-effects, asthma control and overall safety perceptions following coronavirus disease 2019 (COVID-19) vaccination were sent to patients with severe asthma in 12 European countries between May and June 2021.\r\n\r\n660 participants returned completed questionnaires (87.4% response rate). Of these, 88% stated that they had been, or intended to be, vaccinated, 9.5% were undecided/hesitant and 3% had refused vaccination. Patients who hesitated or refused vaccination had more negative beliefs towards vaccination. Most patients reported mild (48.2%) or no side-effects (43.8%). Patients reporting severe side-effects (5.7%) had more negative beliefs. Most patients (88.8%) reported no change in asthma symptoms after vaccination, while 2.4% reported an improvement, 5.3% a slight deterioration and 1.2% a considerable deterioration. Almost all vaccinated (98%) patients would recommend vaccination to other severe asthma patients.\r\n\r\nUptake of vaccination in patients with severe asthma in Europe was high, with a small minority refusing vaccination. Beliefs predicted vaccination behaviour and side-effects. Vaccination had little impact on asthma control. Our findings in people with severe asthma support the broad message that COVID-19 vaccination is safe and well tolerated.", "doi": "10.1183/23120541.00590-2023", "pmid": "38020570", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10680029"}, {"db": "pii", "key": "00590-2023"}], "notes": [], "created": "2023-12-04T07:21:52.526Z", "modified": "2023-12-08T06:01:06.841Z"}, {"entity": "publication", "iuid": "d3cafd522618442d929eaeda25a1cd6a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3cafd522618442d929eaeda25a1cd6a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3cafd522618442d929eaeda25a1cd6a"}}, "title": "Anticoagulant treatment and COVID-19 mortality among older adults living in nursing homes in Sweden.", "authors": [{"family": "Kananen", "given": "Laura", "initials": "L"}, {"family": "Moln\u00e1r", "given": "Christian", "initials": "C", "orcid": "0000-0002-7852-9233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c3da580139e4721bb89fe2b2f9f0aa6.json"}}, {"family": "Ansker", "given": "Fredrik", "initials": "F"}, {"family": "Kozlowska", "given": "Daria Julianna", "initials": "DJ"}, {"family": "H\u00e4gg", "given": "Sara", "initials": "S"}, {"family": "Jylh\u00e4v\u00e4", "given": "Juulia", "initials": "J", "orcid": "0000-0003-0250-4491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/837f950797ef4d46807b86f70adf6b99.json"}}, {"family": "Religa", "given": "Dorota", "initials": "D"}, {"family": "Raaschou", "given": "Pauline", "initials": "P"}], "type": "journal article", "published": "2023-11-00", "journal": {"title": "Health Sci Rep", "issn": "2398-8835", "issn-l": null, "volume": "6", "issue": "11", "pages": "e1692"}, "abstract": "Anticoagulants (AC) were introduced in March 2020 as standard of care in nursing home (NH) residents affected with COVID-19 in the Stockholm region, Sweden. ACs are proven to reduce the risk of complications and mortality from COVID-19 among patients of other ages and settings, but there is limited scientific evidence underpinning this practice in the NH setting.\r\n\r\nThis matched cohort study included 182 NH residents in the Stockholm Region diagnosed with COVID-19 in March-May 2020. The main exposure was any AC treatment. Exposed (n = 91), 49% prevalent (pre-COVID-19 diagnosis) AC and 51% incident AC were compared with unexposed controls (n = 91). The outcome was 28-days all-cause mortality after COVID-19 infection. The mortality odds ratios (OR) were assessed using logistic regression, adjusted for age, sex, multimorbidity, and mobility, also stratified by incident or prevalent AC-type, age group, and sex.\r\n\r\nOf the 182 individuals diagnosed with COVID-19 (median age 88 years, 68% women), 39% died within 28 days after diagnosis. Use of either incident or prevalent AC was associated with a reduced, adjusted 28-day mortality (OR[95% CI]: 0.31[0.16-0.62]). In stratified analyses, the association was significant in both age groups: 70-89 (OR: 0.37 [0.15-0.89]) and 90-99 years of age (OR: 0.22 [0.07-0.65]. In sex-stratified analysis, the AC-lowering effect was significant in women only (OR: 0.28[0.11-0.67]). In the analyses stratified by AC type, the mortality-lowering effect was observed for both prevalent AC (OR: 0.35[0.12-0.99]) and incident AC (OR: 0.29[0.11-0.76]).\r\n\r\nBoth prevalent and incident use of ACs in prophylactic dosing was associated with reduced 28-day mortality among older individuals with COVID-19 in a NH setting. The effect was seen across age-strata and in women. The findings present new insight in best practice for individuals diagnosed with COVID-19 in the NH setting.", "doi": "10.1002/hsr2.1692", "pmid": "38028709", "labels": {"Category: Health": null, "Type: Journal article": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC10644256"}, {"db": "pii", "key": "HSR21692"}], "notes": [], "created": "2023-12-04T07:17:16.178Z", "modified": "2023-12-04T07:43:18.929Z"}, {"entity": "publication", "iuid": "e14641221957473cbaa6b0c49b004b4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e14641221957473cbaa6b0c49b004b4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e14641221957473cbaa6b0c49b004b4c"}}, "title": "Provision and utilization of maternal health services during the COVID-19 pandemic in 16 hospitals in sub-Saharan Africa.", "authors": [{"family": "Semaan", "given": "Aline", "initials": "A"}, {"family": "Annerstedt", "given": "Kristi Sidney", "initials": "KS"}, {"family": "Be\u0148ov\u00e1", "given": "Lenka", "initials": "L"}, {"family": "Dossou", "given": "Jean-Paul", "initials": "J"}, {"family": "Boyi Hounsou", "given": "Christelle", "initials": "C"}, {"family": "Agballa", "given": "Gottfried", "initials": "G"}, {"family": "Namazzi", "given": "Gertrude", "initials": "G"}, {"family": "Kandeya", "given": "Bianca", "initials": "B"}, {"family": "Meja", "given": "Samuel", "initials": "S"}, {"family": "Ally Mkoka", "given": "Dickson", "initials": "D"}, {"family": "Asefa", "given": "Anteneh", "initials": "A"}, {"family": "El-Halabi", "given": "Soha", "initials": "S"}, {"family": "Hanson", "given": "Claudia", "initials": "C"}], "type": "journal article", "published": "2023-10-31", "journal": {"title": "Front Glob Womens Health", "issn": "2673-5059", "issn-l": null, "volume": "4", "issue": null, "pages": "1192473"}, "abstract": "Maintaining provision and utilization of maternal healthcare services is susceptible to external influences. This study describes how maternity care was provided during the COVID-19 pandemic and assesses patterns of service utilization and perinatal health outcomes in 16 referral hospitals (four each) in Benin, Malawi, Tanzania and Uganda.\r\n\r\nWe used an embedded case-study design and two data sources. Responses to open-ended questions in a health-facility assessment survey were analyzed with content analysis. We described categories of adaptations and care provision modalities during the pandemic at the hospital and maternity ward levels. Aggregate monthly service statistics on antenatal care, delivery, caesarean section, maternal deaths, and stillbirths covering 24 months (2019 and 2020; pre-COVID-19 and COVID-19) were examined.\r\n\r\nDeclines in the number of antenatal care consultations were documented in Tanzania, Malawi, and Uganda in 2020 compared to 2019. Deliveries declined in 2020 compared to 2019 in Tanzania and Uganda. Caesarean section rates decreased in Benin and increased in Tanzania in 2020 compared to 2019. Increases in maternal mortality ratio and stillbirth rate were noted in some months of 2020 in Benin and Uganda, with variability noted between hospitals. At the hospital level, teams were assigned to respond to the COVID-19 pandemic, routine meetings were cancelled, and maternal death reviews and quality improvement initiatives were interrupted. In maternity wards, staff shortages were reported during lockdowns in Uganda. Clinical guidelines and protocols were not updated formally; the number of allowed companions and visitors was reduced.\r\n\r\nVarying approaches within and between countries demonstrate the importance of a contextualized response to the COVID-19 pandemic. Maternal care utilization and the ability to provide quality care fluctuated with lockdowns and travel bans. Women's and maternal health workers' needs should be prioritized to avoid interruptions in the continuum of care and prevent the deterioration of perinatal health outcomes.", "doi": "10.3389/fgwh.2023.1192473", "pmid": "38025986", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10644718"}], "notes": [], "created": "2023-12-04T07:18:16.692Z", "modified": "2023-12-04T08:07:11.348Z"}, {"entity": "publication", "iuid": "54cb5038515147a5952e31eff6e99aa1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54cb5038515147a5952e31eff6e99aa1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54cb5038515147a5952e31eff6e99aa1"}}, "title": "Cost of the COVID-19 pandemic versus the cost-effectiveness of mitigation strategies in EU/UK/OECD: a systematic review.", "authors": [{"family": "Vardavas", "given": "Constantine", "initials": "C", "orcid": "0000-0003-0171-9570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0159edc853c4cce9639d8a845efc820.json"}}, {"family": "Zisis", "given": "Konstantinos", "initials": "K"}, {"family": "Nikitara", "given": "Katerina", "initials": "K", "orcid": "0000-0002-7270-6278", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90ee8c933fa74dfd9da7692d1598e909.json"}}, {"family": "Lagou", "given": "Ioanna", "initials": "I"}, {"family": "Marou", "given": "Valia", "initials": "V"}, {"family": "Aslanoglou", "given": "Katerina", "initials": "K"}, {"family": "Athanasakis", "given": "Konstantinos", "initials": "K"}, {"family": "Phalkey", "given": "Revati", "initials": "R"}, {"family": "Leonardi-Bee", "given": "Jo", "initials": "J", "orcid": "0000-0003-0893-6068", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8701f9786c0743f8acfd8057d258c2b2.json"}}, {"family": "Fernandez", "given": "Esteve", "initials": "E", "orcid": "0000-0003-4239-723X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/675eab40110e4b35b75806cfe231c4f0.json"}}, {"family": "Condell", "given": "Orla", "initials": "O"}, {"family": "Lamb", "given": "Favelle", "initials": "F"}, {"family": "Sandmann", "given": "Frank", "initials": "F"}, {"family": "Pharris", "given": "Anastasia", "initials": "A"}, {"family": "Deogan", "given": "Charlotte", "initials": "C"}, {"family": "Suk", "given": "Jonathan E", "initials": "JE", "orcid": "0000-0003-4689-4583", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9492c0def39d44fe938979ac74c0f5be.json"}}], "type": "systematic review", "published": "2023-10-31", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "10", "pages": "e077602"}, "abstract": "The economic burden of COVID-19 pandemic is substantial, with both direct and indirect costs playing a significant role.\r\n\r\nA systematic literature review was conducted to estimate the cost of the COVID-19 pandemic and the cost-effectiveness of pharmaceutical or non-pharmaceutical interventions. All cost data were adjusted to the 2021 Euro, and interventions compared with null.\r\n\r\nOvid MEDLINE and EMBASE were searched from January 2020 through 22 April 2021.\r\n\r\nStudies regarding COVID-19 outbreak or public health preparedness measures or interventions with outcome measures related to the direct and indirect costs for disease and preparedness and/or response in countries of the European Union (EU), the European Economic Area (EEA), the UK and the Organisation for Economic Co-operation and Development (OECD) of all relevant epidemiological designs which estimate cost within the selected time frame were considered eligible.\r\n\r\nStudies were searched, screened and coded independently by two reviewers with high measure of inter-rater agreement. Data were extracted to a predefined data extraction sheet. The risk of bias was assessed using the Consensus on Health Economic Criteria checklist.\r\n\r\nWe included data from 41 economic studies. Ten studies evaluated the cost of the COVID-19 pandemic, while 31 assessed the cost-benefit of public health surveillance, preparedness and response measures. Overall, the economic burden of the COVID-19 pandemic was found to be substantial. Community screening, bed provision policies, investing in personal-protective-equipment and vaccination strategies were cost-effective. Physical distancing measures were associated with health benefits; however, their cost-effectiveness was dependent on the duration, compliance and the phase of the epidemic in which it was implemented.\r\n\r\nCOVID-19 pandemic is associated with substantial short-term and long-term economic costs to healthcare systems, payers and societies, while interventions including testing and screening policies, vaccination and physical distancing policies were identified as those presenting cost-effective options to deal with the pandemic, dependent on population vaccination and the Re at the stage of the pandemic.", "doi": "10.1136/bmjopen-2023-077602", "pmid": "37907290", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10619092"}, {"db": "pii", "key": "bmjopen-2023-077602"}], "notes": [], "created": "2023-12-04T07:18:21.734Z", "modified": "2023-12-04T08:09:40.929Z"}, {"entity": "publication", "iuid": "11826c7f42bd491d80a67fe6d4f63446", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/11826c7f42bd491d80a67fe6d4f63446.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/11826c7f42bd491d80a67fe6d4f63446"}}, "title": "The sociodemographic patterning of sick leave and determinants of longer sick leave after mild and severe COVID-19: a nationwide register-based study in Sweden.", "authors": [{"family": "Spetz", "given": "Malin", "initials": "M"}, {"family": "Natt Och Dag", "given": "Yvonne", "initials": "Y"}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Nwaru", "given": "Chioma", "initials": "C"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Rosvall", "given": "Maria", "initials": "M", "orcid": "0000-0002-7122-9940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b220132e7064d50bb6649cd82a5bb42.json"}}], "type": "journal article", "published": "2023-10-27", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": null, "issue": null, "pages": null}, "abstract": "Studies on sociodemographic differences in sick leave after coronavirus disease 2019 (COVID-19) are limited and research on COVID-19 long-term health consequences has mainly addressed hospitalized individuals. The aim of this study was to investigate the social patterning of sick leave and determinants of longer sick leave after COVID-19 among mild and severe cases.\r\n\r\nThe study population, from the Swedish multi-register observational study SCIFI-PEARL, included individuals aged 18-64 years in the Swedish population, gainfully employed, with a first positive polymerase chain reaction (PCR) test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from 1 January 2020 until 31 August 2021 (n = 661 780). Using logistic regression models, analyses were adjusted for sociodemographic factors, vaccination, prior sick leave, comorbidities and stratified by hospitalization.\r\n\r\nIn total, 37 420 (5.7%) individuals were on sick leave due to COVID-19 in connection with their first positive COVID-19 test. Individuals on sick leave were more often women, older, had lower income and/or were born outside Sweden. These differences were similar across COVID-19 pandemic phases. The highest proportion of sick leave was seen in the oldest age group (10.3%) with an odds ratio of 4.32 (95% confidence interval 4.18-4.47) compared with the youngest individuals. Among individuals hospitalized due to COVID-19, the sociodemographic pattern was less pronounced, and in some models, even reversed. The intersectional analysis revealed considerable variability in sick leave between sociodemographic groups (range: 1.5-17.0%).\r\n\r\nIn the entire Swedish population of gainfully employed individuals, our findings demonstrated evident sociodemographic differences in sick leave due to COVID-19. In the hospitalized group, the social patterning was different and less pronounced.", "doi": "10.1093/eurpub/ckad191", "pmid": "37889580", "labels": {"Funder: VR": null, "Category: Social Science & Humanities": null, "Funder: KAW/SciLifeLab": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7331116"}], "notes": [], "created": "2023-11-01T13:31:38.666Z", "modified": "2023-11-01T13:43:47.208Z"}, {"entity": "publication", "iuid": "fb599ad2ca4f4be9a1aa5332016357b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb599ad2ca4f4be9a1aa5332016357b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb599ad2ca4f4be9a1aa5332016357b9"}}, "title": "New insights from Norwegian and Swedish sports coaches' employment, practices, and beliefs during the first COVID-19 restriction period.", "authors": [{"family": "Severin", "given": "Anna Cecilia", "initials": "AC"}, {"family": "Skovereng", "given": "Knut", "initials": "K"}, {"family": "Bj\u00f6rklund", "given": "Glenn", "initials": "G"}, {"family": "Hemmestad", "given": "Liv", "initials": "L"}, {"family": "Sandbakk", "given": "\u00d8yvind", "initials": "\u00d8"}, {"family": "Bucher Sandbakk", "given": "Silvana", "initials": "S"}], "type": "journal article", "published": "2023-10-27", "journal": {"title": "Front Sports Act Living", "issn": "2624-9367", "issn-l": null, "volume": "5", "issue": null, "pages": "1277228"}, "abstract": "This study (i) examined Norwegian and Swedish sports coaches' employment, practices, and beliefs during the first wave of the COVID-19 pandemic, (ii) compared these aspects between coaches in Norway and Sweden, two countries with clearly different movement restrictions strategies in this period.\r\n\r\nAn online survey was distributed to coaches via email and social media. The survey was open between June and August 2020. In total, 348 coaches responded, 141 from Norway, and 207 from Sweden.\r\n\r\nAmong responders, 2% had lost their job due to the pandemic, 17% had been furloughed, 28% worked from home office, and 39% worked as usual. Norwegian coaches were more likely to work from home (48% vs. 15%, p < .001), while Swedish coaches were more likely to work as usual (60% vs. 9%, p < .001). Coaches in both countries communicated less frequently with their athletes (p < .001) and had less in-person communication (p < .001) compared to pre-Covid levels. Larger declines existed among Norwegian coaches regarding communication frequency (p < .001) and in-person communication (p < .001). Video calls and phone calls usage increased (p < .001 and p = .009 respectively). We recorded low levels of concern among coaches about the effects of the pandemic on their relationship with their athletes. There were considerable levels of concern about athletes' maintaining their motivation to train (Norway: 43.3%, Sweden: 50.7%), and low levels of concern about the coaches' relationships with their athletes (Norway: 14.1%, Sweden: 17.8%).\r\n\r\nOverall, this study showed the imposed movement restrictions had several negative consequences for the employment and work practices of sports coaches in Norway and Sweden. However, it also highlighted that coaches were able to adapt their work practices to the constraints and were able to maintain relationships with their athletes. The consequences raised in this paper can act as a guide during possible future lockdowns.", "doi": "10.3389/fspor.2023.1277228", "pmid": "37964775", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10641774"}], "notes": [], "created": "2023-12-04T07:22:16.553Z", "modified": "2023-12-08T06:11:50.303Z"}, {"entity": "publication", "iuid": "a3623fd6bde943a695f15b060417e12f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3623fd6bde943a695f15b060417e12f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3623fd6bde943a695f15b060417e12f"}}, "title": "How did providers of home care for older adults manage the early phase of the Covid-19 pandemic? A qualitative case study of managers' experiences in Region Stockholm.", "authors": [{"family": "Agerholm", "given": "Janne", "initials": "J"}, {"family": "Burstr\u00f6m", "given": "Bo", "initials": "B"}, {"family": "Sch\u00f6n", "given": "P\u00e4r", "initials": "P"}, {"family": "Liljas", "given": "Ann", "initials": "A"}], "type": "journal article", "published": "2023-10-27", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "issn-l": null, "volume": "23", "issue": "1", "pages": "1173"}, "abstract": "In the spring of 2020, the Covid-19 outbreak sent a shock wave through the Swedish society and placed an extraordinary pressure on the health and social care system for older people. In the initial phase there were few guidelines for care providers to follow and staff in home care organisations often had to tackle challenges posed by the pandemic as they appeared. The aim of this study was to understand how the spread of Covid-19 was managed in organisations providing home care to older adults in different municipalities in Region Stockholm, and what actions were taken to minimise the spread of the disease among clients and staff.\r\n\r\nA descriptive qualitative study was performed based on eight interviews with managers of home care providers for older adults in three different municipalities in Region Stockholm.Three of the eight providers operate within an integrated care system. Data were analysed using conventional content analysis.\r\n\r\nThree themes were identified covering actions taken to handle the spread of the virus, feelings of insecurity and anxiety, and internal and external factors influencing how the pandemic was tackled. There was no single strategy followed by all municipalities or organisations, however, there were similarities between the organisations. One such example was the introduction of cohort care and the experience of lacking personal protective equipment. Providers in the integrated care system emphasized some advantages with their system that was seen as facilitators for minimising the risk of spreading the virus, like the joint meetings with managers from both health and social care and the close contact with healthcare professionals in relation to dissemination of hygiene instructions.\r\n\r\nSocial care workers providing home care to older persons are an important group in preventing dissemination of infectious diseases like Covid-19. For better readiness and preparedness for future pandemics, municipal home care services would need larger stocks of personal protective equipment, clear guidelines and more training on how to reduce dissemination of disease. Ways to achieve closer communication between health and social care providers should also be investigated.", "doi": "10.1186/s12913-023-10173-8", "pmid": "37891523", "labels": {"Funder: VR": null, "Funder: Forte": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10612274"}, {"db": "pii", "key": "10.1186/s12913-023-10173-8"}], "notes": [], "created": "2023-11-01T13:32:23.591Z", "modified": "2023-11-02T07:03:41.915Z"}, {"entity": "publication", "iuid": "389a662518cd4a27a53b699cd6cea155", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/389a662518cd4a27a53b699cd6cea155.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/389a662518cd4a27a53b699cd6cea155"}}, "title": "Associations between psychosocial wellbeing and experience of gender-based violence at community, household, and intimate-partner levels among a cross-sectional cohort of young people living with and without HIV during COVID-19 in Cape Town, South Africa.", "authors": [{"family": "Hartmann", "given": "Miriam", "initials": "M"}, {"family": "Giovenco", "given": "Danielle", "initials": "D"}, {"family": "Zeebari", "given": "Zangin", "initials": "Z"}, {"family": "Itzikowitz", "given": "Gina", "initials": "G"}, {"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM"}, {"family": "Nielsen", "given": "Anna", "initials": "A"}, {"family": "Pettifor", "given": "Audrey", "initials": "A"}, {"family": "Bekker", "given": "Linda-Gail", "initials": "L"}, {"family": "K\u00e5gesten", "given": "Anna E", "initials": "AE"}], "type": "journal article", "published": "2023-10-27", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "23", "issue": "1", "pages": "2115"}, "abstract": "Growing evidence indicates that gender-based violence (GBV) increased during COVID-19. We investigated self-reported impact of the pandemic on GBV at community, household and intimate partner (IPV) levels among young people and its associations with psychosocial wellbeing, i.e., COVID-related stressors and mental health.\r\n\r\nCross-sectional data were drawn from a survey with young people ages 13-24 (N = 536) living with HIV (YPLWH) and without HIV (YPLWoH), in peri-urban Cape Town, South Africa. The survey, conducted February-October 2021, examined the impact of the initial lockdown on experience and perceived changes in GBV at each level, and pandemic-related psychosocial wellbeing. Descriptive statistics and binomial and multinomial regression analyses were conducted to illustrate exposure and perceived changes in GBV since lockdown, and their association with COVID-related stress factors (e.g., social isolation, anxiety about COVID), mental health (e.g., depression, anxiety), and other risk factors (e.g., age, gender, socioeconomic status) by HIV status.\r\n\r\nParticipants were 70% women with mean age 19 years; 40% were living with HIV. Since lockdown, YPLWoH were significantly more likely than YPLWH to perceive community violence as increasing (45% vs. 28%, p < 0.001), and to report household violence (37% vs. 23%, p = 0.006) and perceive it as increasing (56% vs. 27%, p = 0.002) (ref: decreasing violence). YPLWoH were also more likely to report IPV experience (19% vs. 15%, p = 0.41) and perception of IPV increasing (15% vs. 8%, p = 0.92). In adjusted models, COVID-related stressors and common mental health disorders were only associated with household violence. However, indicators of economic status such as living in informal housing (RRR = 2.07; 95% CI = 1.12-3.83) and food insecurity (Community violence: RRR = 1.79; 95% CI = 1.00-3.20; Household violence: RRR = 1.72; 95% CI = 1.15-2.60) emerged as significant risk factors for exposure to increased GBV particularly among YPLWoH.\r\n\r\nFindings suggest that for young people in this setting, GBV at community and household levels was more prevalent during COVID-19 compared to IPV, especially for YPLWoH. While we found limited associations between COVID-related stressors and GBV, the perceived increases in GBV since lockdown in a setting where GBV is endemic, and the association of household violence with mental health, is a concern for future pandemic responses and should be longitudinally assessed.", "doi": "10.1186/s12889-023-16945-5", "pmid": "37891509", "labels": {"Funder: VR": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10612288"}, {"db": "pii", "key": "10.1186/s12889-023-16945-5"}], "notes": [], "created": "2023-11-01T13:33:27.833Z", "modified": "2023-11-02T07:22:42.743Z"}, {"entity": "publication", "iuid": "2232c85abf2b4e13ae16b60025ee1d92", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2232c85abf2b4e13ae16b60025ee1d92.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2232c85abf2b4e13ae16b60025ee1d92"}}, "title": "Outcomes of SARS-CoV-2 Omicron Variant Infections Compared with Seasonal Influenza and Respiratory Syncytial Virus Infections in Adults Attending the Emergency Department: A Multicentre Cohort Study.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P", "orcid": "0000-0003-3153-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd6af5accfc84ff9a81983a5ab6683aa.json"}}, {"family": "Karlsson Valik", "given": "John", "initials": "J", "orcid": "0000-0002-4521-1886", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eac431272ad4d8eb13c8d56ddef182c.json"}}, {"family": "Abdel Halim", "given": "Lina", "initials": "L"}, {"family": "Alfv\u00e9n", "given": "Tobias", "initials": "T", "orcid": "0000-0002-2328-3512", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3851560b984401780a380ab1262cd8b.json"}}, {"family": "Naucler", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2023-10-26", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "issn-l": "1058-4838", "volume": null, "issue": null, "pages": null}, "abstract": "There is a controversy over the impact of SARS-CoV-2 infections in an era of less virulent variants and an increasing population immunity. We compared outcomes in adults attending the emergency department (ED) with an Omicron, influenza, or respiratory syncytial virus (RSV) infection.\r\n\r\nRetrospective multicentre cohort study including adults attending the ED in six acute care hospitals in Stockholm County, Sweden, with an Omicron, influenza, or RSV infection during 2021-22 and 2015-19. During 2021-22, patients were tested for all three viruses by multiplex PCR testing. The primary outcome was 30-day all-cause mortality. Secondary outcomes were 90-day all-cause mortality, hospitalization, and intensive care unit (ICU) admission.\r\n\r\nA total of 6,385 patients from 2021-22 were included in the main analyses: 4,833 Omicron, 1,099 influenza, and 453 RSV. The 30-day mortality was 7.9% (n=381) in the Omicron, 2.5% (n=28) in the influenza, and 6.0% (n=27) in the RSV cohort. Patients with Omicron had an adjusted 30-day mortality odds ratio (OR) of 2.36 (95% confidence interval [CI] 1.60-3.62) compared with influenza and 1.42 (95% CI 0.94-2.21) compared with RSV. Among unvaccinated Omicron patients, stronger associations were observed compared with both influenza (OR 5.51 [95% CI 3.41-9.18]) and RSV (OR 3.29 [95% CI 2.01-5.56]). Similar trends were observed for secondary outcomes. Findings were consistent in comparisons with 5,709 pre-pandemic influenza 995 RSV patients.\r\n\r\nIn patients attending the ED, infections with Omicron were both more common and associated with more severe outcomes compared with influenza and RSV, in particular among unvaccinated patients.", "doi": "10.1093/cid/ciad660", "pmid": "37883521", "labels": {"Funder: VR": null, "Category: Health": null, "Category: Vaccines": null, "Funder: H2020": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7330559"}], "notes": [], "created": "2023-11-01T13:34:17.238Z", "modified": "2023-11-02T07:47:44.463Z"}, {"entity": "publication", "iuid": "cfcf4b588dcc4cdb8f4ad99979423778", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfcf4b588dcc4cdb8f4ad99979423778.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfcf4b588dcc4cdb8f4ad99979423778"}}, "title": "Cardiovascular dysautonomia in postacute sequelae of SARS-CoV-2 infection.", "authors": [{"family": "St\u00e5hlberg", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0319-6240", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75523cbe45e04142bb03b50707b96804.json"}}, {"family": "Mahdi", "given": "Ali", "initials": "A"}, {"family": "Johansson", "given": "Madeleine", "initials": "M", "orcid": "0000-0001-9057-9148", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f86daf2351f0466f83705bfa26ba0b4a.json"}}, {"family": "Fedorowski", "given": "Artur", "initials": "A", "orcid": "0000-0002-5352-6327", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2ef9375bfba4311868834aec838c8a3.json"}}, {"family": "Olshansky", "given": "Brian", "initials": "B", "orcid": "0000-0002-6044-045X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21da77c6851743e688ce07c56cb0ba75.json"}}], "type": "journal article", "published": "2023-10-25", "journal": {"title": "J Cardiovasc Electrophysiol", "issn": "1540-8167", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Coronavirus disease 2019 (COVID-19) has led to a worldwide pandemic that continues to transform but will not go away. Cardiovascular dysautonomia in postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection has led to persistent symptoms in a large number of patients. Here, we define the condition and its associated symptoms as well as potential mechanisms responsible. We provide a careful and complete overview of the topic addressing novel studies and a generalized approach to the management of individuals with this complex and potentially debilitating problem. We also discuss future research directions and the important knowledge gaps to be addressed in ongoing and planned studies.", "doi": "10.1111/jce.16117", "pmid": "37877234", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:33:10.141Z", "modified": "2023-11-02T07:14:18.246Z"}, {"entity": "publication", "iuid": "2d681a8066d842df8318bbad966b4f7c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d681a8066d842df8318bbad966b4f7c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d681a8066d842df8318bbad966b4f7c"}}, "title": "The role of primary health care in long-term care facilities during the COVID-19 pandemic in 30 European countries: a retrospective descriptive study (Eurodata study).", "authors": [{"family": "Guisado-Clavero", "given": "Marina", "initials": "M", "orcid": "0000-0002-8448-2929", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe6cb00ce6e64ea9ae551a4a65c1093c.json"}}, {"family": "Ares-Blanco", "given": "Sara", "initials": "S", "orcid": "0000-0002-4984-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5929b4be5ff946a2af9b33fde3fb09ec.json"}}, {"family": "Serafini", "given": "Alice", "initials": "A", "orcid": "0000-0002-7396-2839", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dfd0165d3afe49f49370124c8a379a81.json"}}, {"family": "Del Rio", "given": "Lourdes Ramos", "initials": "LR", "orcid": "0000-0003-4850-2053", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/629e28d8cf1d4ba3926ba037e14f5742.json"}}, {"family": "Larrondo", "given": "Ileana Gefaell", "initials": "IG", "orcid": "0000-0002-1635-1003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a6e202b315e4966a1fc58919d4f4e4e.json"}}, {"family": "Fitzgerald", "given": "Louise", "initials": "L", "orcid": "0009-0009-8039-3097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54a11aeb7912445e91a8861314dc9dc3.json"}}, {"family": "Vinker", "given": "Shlomo", "initials": "S"}, {"family": "van Pottebergh", "given": "Gijs", "initials": "G"}, {"family": "Valtonen", "given": "Kirsi", "initials": "K"}, {"family": "Vaes", "given": "Bert", "initials": "B"}, {"family": "Yilmaz", "given": "Canan Tuz", "initials": "CT"}, {"family": "Torzsa", "given": "P\u00e9ter", "initials": "P"}, {"family": "Tilli", "given": "Paula", "initials": "P"}, {"family": "Sentker", "given": "Theresa", "initials": "T"}, {"family": "Seifert", "given": "Bohumil", "initials": "B"}, {"family": "Saurek-Aleksandrovska", "given": "Natalija", "initials": "N"}, {"family": "Sattler", "given": "Martin", "initials": "M"}, {"family": "Petricek", "given": "Goranka", "initials": "G"}, {"family": "Petrazzuoli", "given": "Ferdinando", "initials": "F"}, {"family": "Petek", "given": "Davorina", "initials": "D"}, {"family": "Perj\u00e9s", "given": "\u00c1bel", "initials": "\u00c1"}, {"family": "L\u00f3pez", "given": "Naldy Parodi", "initials": "NP"}, {"family": "Neves", "given": "Ana Luisa", "initials": "AL"}, {"family": "Murauskien\u0117", "given": "Liubov\u0117", "initials": "L"}, {"family": "Lingner", "given": "Heidrun", "initials": "H"}, {"family": "Nessler", "given": "Katarzyna", "initials": "K"}, {"family": "Heleno", "given": "Bruno", "initials": "B"}, {"family": "Krzto\u0144-Kr\u00f3lewiecka", "given": "Anna", "initials": "A"}, {"family": "Kosti\u0107", "given": "Milena", "initials": "M"}, {"family": "Korkmaz", "given": "B\u00fcsra \u00c7imen", "initials": "B\u00c7"}, {"family": "Kne\u017eevi\u0107", "given": "Sne\u017eana", "initials": "S"}, {"family": "Kirkovski", "given": "Aleksandar", "initials": "A"}, {"family": "Karathanos", "given": "Vasilis Trifon", "initials": "VT"}, {"family": "Jandri\u0107-Ko\u010di\u0107", "given": "Marijana", "initials": "M"}, {"family": "Ivanna", "given": "Shushman", "initials": "S"}, {"family": "\u0406\u043b\u044c\u043a\u043e\u0432", "given": "\u041e\u043a\u0441\u0430\u043d\u0430", "initials": "\u041e"}, {"family": "Hoffmann", "given": "Kathryn", "initials": "K"}, {"family": "Han\u017eeva\u010dki", "given": "Miroslav", "initials": "M"}, {"family": "G\u00f3mez-Johansson", "given": "Mila", "initials": "M"}, {"family": "Gjorgjievski", "given": "Dragan", "initials": "D"}, {"family": "Domeyer", "given": "Philippe-Richard J", "initials": "PJ"}, {"family": "Pe\u00f1a", "given": "Maryher Delphin", "initials": "MD"}, {"family": "Divjak", "given": "Asja \u0106osi\u0107", "initials": "A\u0106"}, {"family": "Busneag", "given": "Iliana-Carmen", "initials": "I"}, {"family": "Brutskaya-Stempkovskaya", "given": "Elena", "initials": "E"}, {"family": "Bayen", "given": "Sabine", "initials": "S"}, {"family": "Bakola", "given": "Maria", "initials": "M"}, {"family": "Adler", "given": "Limor", "initials": "L"}, {"family": "Assenova", "given": "Radost", "initials": "R"}, {"family": "Astier-Pe\u00f1a", "given": "Mar\u00eda Pilar", "initials": "MP", "orcid": "0000-0002-3192-7672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/585b3e1ed7df4d63b0342ab0d96ef9c4.json"}}, {"family": "G\u00f3mez Bravo", "given": "Raquel", "initials": "R"}], "type": "journal article", "published": "2023-10-24", "journal": {"title": "Prim Health Care Res Dev", "issn": "1477-1128", "issn-l": null, "volume": "24", "issue": null, "pages": "e60"}, "abstract": "Primary health care (PHC) supported long-term care facilities (LTCFs) in attending COVID-19 patients. The aim of this study is to describe the role of PHC in LTCFs in Europe during the early phase of the pandemic.\r\n\r\nRetrospective descriptive study from 30 European countries using data from September 2020 collected with an ad hoc semi-structured questionnaire. Related variables are SARS-CoV-2 testing, contact tracing, follow-up, additional testing, and patient care.\r\n\r\nTwenty-six out of the 30 European countries had PHC involvement in LTCFs during the COVID-19 pandemic. PHC participated in initial medical care in 22 countries, while, in 15, PHC was responsible for SARS-CoV-2 test along with other institutions. Supervision of individuals in isolation was carried out mostly by LTCF staff, but physical examination or symptom's follow-up was performed mainly by PHC.\r\n\r\nPHC has participated in COVID-19 pandemic assistance in LTCFs in coordination with LTCF staff, public health officers, and hospitals.", "doi": "10.1017/S1463423623000312", "pmid": "37873623", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10594530"}, {"db": "pii", "key": "S1463423623000312"}], "notes": [], "created": "2023-11-01T13:31:47.959Z", "modified": "2023-11-01T13:48:56.332Z"}, {"entity": "publication", "iuid": "b5f16d32127a4318ba630294e5793728", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5f16d32127a4318ba630294e5793728.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5f16d32127a4318ba630294e5793728"}}, "title": "COVID-19 Recovery: Consistent Absence of Cerebrospinal Fluid Biomarker Abnormalities in Patients With Neurocognitive Post-COVID Complications.", "authors": [{"family": "Kanberg", "given": "Nelly", "initials": "N", "orcid": "0000-0002-1064-995X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84d593bfda8f42688e9d4fe713158679.json"}}, {"family": "Grahn", "given": "Anna", "initials": "A"}, {"family": "Stentoft", "given": "Erika", "initials": "E"}, {"family": "Bremell", "given": "Daniel", "initials": "D"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Studahl", "given": "Marie", "initials": "M"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Sch\u00f6ll", "given": "Michael", "initials": "M", "orcid": "0000-0001-7800-1781", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebf046923a9d4540a7a72578663116f2.json"}}, {"family": "Gostner", "given": "Johanna M", "initials": "JM"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Padmanabhan", "given": "Nikhil", "initials": "N"}, {"family": "Cohen", "given": "Rachel", "initials": "R"}, {"family": "Misaghian", "given": "Salvia", "initials": "S"}, {"family": "Romero", "given": "Daniel", "initials": "D"}, {"family": "Campbell", "given": "Christopher", "initials": "C"}, {"family": "Mathew", "given": "Anu", "initials": "A", "orcid": "0000-0003-3327-3083", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc281597abd2491499abebd7bf90fb20.json"}}, {"family": "Wang", "given": "Mingyue", "initials": "M"}, {"family": "Sigal", "given": "George", "initials": "G", "orcid": "0000-0001-7149-6400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5a9e814e36040718224e726b320c248.json"}}, {"family": "Stengelin", "given": "Martin", "initials": "M"}, {"family": "Ed\u00e9n", "given": "Arvid", "initials": "A", "orcid": "0000-0003-2817-9981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54411b4f4cbe422697c5eb3080c23e2c.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2023-10-24", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899", "volume": null, "issue": null, "pages": null}, "abstract": "To investigate evidence of residual viral infection, intrathecal immune activation, central nervous system (CNS) injury, and humoral responses in cerebrospinal fluid (CSF) and plasma in patients recovering from coronavirus disease 2019 (COVID-19), with or without neurocognitive post-COVID condition (PCC).\r\n\r\nThirty-one participants (25 with neurocognitive PCC) underwent clinical examination, lumbar puncture, and venipuncture \u22653 months after COVID-19 symptom onset. Healthy volunteers were included. CSF and plasma severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid and spike antigen (N-Ag, S-Ag), and CSF biomarkers of immune activation and neuronal injury were analyzed.\r\n\r\nSARS-CoV-2 N-Ag or S-Ag were undetectable in all samples and no participant had pleocytosis. We detected no significant differences in CSF and plasma cytokine concentrations, albumin ratio, IgG index, neopterin, \u03b22M, or in CSF biomarkers of neuronal injury and astrocytic damage. Furthermore, principal component analysis (PCA1) analysis did not indicate any significant differences between the study groups in the marker sets cytokines, neuronal markers, or anti-cytokine autoantibodies.\r\n\r\nWe found no evidence of ongoing viral replication, immune activation, or CNS injury in plasma or CSF in patients with neurocognitive PCC compared with COVID-19 controls or healthy volunteers, suggesting that neurocognitive PCC is a consequence of events suffered during acute COVID-19 rather than persistent viral CNS infection or residual CNS inflammation.", "doi": "10.1093/infdis/jiad395", "pmid": "37874918", "labels": {"Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7328977"}], "notes": [], "created": "2023-11-01T13:31:31.776Z", "modified": "2023-11-01T13:41:08.175Z"}, {"entity": "publication", "iuid": "8c84afdc1dc24b0f953ef8e3d9be3979", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c84afdc1dc24b0f953ef8e3d9be3979.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c84afdc1dc24b0f953ef8e3d9be3979"}}, "title": "MRI with generalized diffusion encoding reveals damaged white matter in patients previously hospitalized for COVID-19 and with persisting symptoms at follow-up.", "authors": [{"family": "Boito", "given": "Deneb", "initials": "D"}, {"family": "Eklund", "given": "Anders", "initials": "A"}, {"family": "Tisell", "given": "Anders", "initials": "A"}, {"family": "Levi", "given": "Richard", "initials": "R"}, {"family": "\u00d6zarslan", "given": "Evren", "initials": "E"}, {"family": "Blystad", "given": "Ida", "initials": "I", "orcid": "0000-0002-8857-5698", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5501de014fd4b93894a0e9c8c8b8e14.json"}}], "type": "journal article", "published": "2023-10-22", "journal": {"title": "Brain Commun", "issn": "2632-1297", "issn-l": null, "volume": "5", "issue": "6", "pages": "fcad284"}, "abstract": "There is mounting evidence of the long-term effects of COVID-19 on the central nervous system, with patients experiencing diverse symptoms, often suggesting brain involvement. Conventional brain MRI of these patients shows unspecific patterns, with no clear connection of the symptomatology to brain tissue abnormalities, whereas diffusion tensor studies and volumetric analyses detect measurable changes in the brain after COVID-19. Diffusion MRI exploits the random motion of water molecules to achieve unique sensitivity to structures at the microscopic level, and new sequences employing generalized diffusion encoding provide structural information which are sensitive to intravoxel features. In this observational study, a total of 32 persons were investigated: 16 patients previously hospitalized for COVID-19 with persisting symptoms of post-COVID condition (mean age 60 years: range 41-79, all male) at 7-month follow-up and 16 matched controls, not previously hospitalized for COVID-19, with no post-COVID symptoms (mean age 58 years, range 46-69, 11 males). Standard MRI and generalized diffusion encoding MRI were employed to examine the brain white matter of the subjects. To detect possible group differences, several tissue microstructure descriptors obtainable with the employed diffusion sequence, the fractional anisotropy, mean diffusivity, axial diffusivity, radial diffusivity, microscopic anisotropy, orientational coherence (Cc) and variance in compartment's size (CMD) were analysed using the tract-based spatial statistics framework. The tract-based spatial statistics analysis showed widespread statistically significant differences (P < 0.05, corrected for multiple comparisons using the familywise error rate) in all the considered metrics in the white matter of the patients compared to the controls. Fractional anisotropy, microscopic anisotropy and Cc were lower in the patient group, while axial diffusivity, radial diffusivity, mean diffusivity and CMD were higher. Significant changes in fractional anisotropy, microscopic anisotropy and CMD affected approximately half of the analysed white matter voxels located across all brain lobes, while changes in Cc were mainly found in the occipital parts of the brain. Given the predominant alteration in microscopic anisotropy compared to Cc, the observed changes in diffusion anisotropy are mostly due to loss of local anisotropy, possibly connected to axonal damage, rather than white matter fibre coherence disruption. The increase in radial diffusivity is indicative of demyelination, while the changes in mean diffusivity and CMD are compatible with vasogenic oedema. In summary, these widespread alterations of white matter microstructure are indicative of vasogenic oedema, demyelination and axonal damage. These changes might be a contributing factor to the diversity of central nervous system symptoms that many patients experience after COVID-19.", "doi": "10.1093/braincomms/fcad284", "pmid": "37953843", "labels": {"Category: Health": null, "Type: Journal article": null, "Funder: Vinnova": null}, "xrefs": [{"db": "pmc", "key": "PMC10638510"}, {"db": "pii", "key": "fcad284"}], "notes": [], "created": "2023-12-04T07:17:34.986Z", "modified": "2023-12-04T07:56:51.263Z"}, {"entity": "publication", "iuid": "2817222fdd3a4e4b90b4f90242a904e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2817222fdd3a4e4b90b4f90242a904e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2817222fdd3a4e4b90b4f90242a904e8"}}, "title": "Health-related quality of life after surviving intensive care for COVID-19: a prospective multicenter cohort study.", "authors": [{"family": "Halvorsen", "given": "Peter", "initials": "P"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "H\u00e4stbacka", "given": "Johanna", "initials": "J"}, {"family": "Larsson", "given": "Ing-Marie", "initials": "I"}, {"family": "Eklund", "given": "Rakel", "initials": "R"}, {"family": "Arnberg", "given": "Filip K", "initials": "FK"}, {"family": "Hokkanen", "given": "Laura", "initials": "L"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Wallin", "given": "Ewa", "initials": "E"}, {"family": "Orwelius", "given": "Lotti", "initials": "L"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}], "type": "journal article", "published": "2023-10-21", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "18035"}, "abstract": "In survivors of severe coronavirus disease 2019 (COVID-19) incomplete mental and physical recovery may considerably impact daily activities and health-related quality of life (HRQoL). HRQoL can be evaluated with the RAND-36 questionnaire, a multidimensional instrument that assesses physical and mental aspects of health in eight dimensions. The objective was to investigate HRQoL in intensive care patients previously treated for COVID-19 at three Nordic university hospitals, in a prospective multi-center cohort study. HRQoL was measured using RAND-36, 3-9 months after discharge from intensive care units (ICU). One hospital performed a second follow-up 12 months after discharge. A score under the lower limit of the 95% confidence interval in the reference cohorts was considered as significantly reduced HRQoL. We screened 542 and included 252 patients. There was more than twice as many male (174) as female (78) patients and the median age was 61 (interquartile range, IQR 52-69) years. Hypertension was the most common comorbidity observed in 132 (52%) patients and 121 (48%) patients were mechanically ventilated for a median of 8 (IQR 4-14) days. In RAND-36 physical functioning, physical role functioning, general health (p < 0.001 for all) and social functioning (p < 0.05) were below reference, whereas bodily pain, emotional role functioning and mental health were not. In a time-to-event analysis female sex was associated with a decreased chance of reaching the reference HRQoL in the physical function, bodily pain and mental health dimensions. Higher body mass index was found in the physical functioning dimension and hypertension in the physical functioning, vitality and social functioning dimensions. Similar results were seen for diabetes mellitus in general health, vitality and mental health dimensions, as well as pulmonary illness in the physical role functioning dimension and psychiatric diagnosis in the social functioning dimension. Mechanical ventilation was associated with a decreased likelihood of achieving reference HRQoL in the bodily pain and physical functioning dimensions. Patients treated in an ICU because of COVID-19 had lower HRQoL 3-9 months after ICU discharge than 95% of the general population. Physical dimensions were more severely affected than mental dimensions. Female sex and several comorbidities were associated with a slower rate of recovery.Study registration: clinicaltrials.gov: NCT04316884 registered on the 13th of March 2020, NCT04474249 registered on the 29th of June 2020 and NCT04864938 registered on the 4th of April 2021.", "doi": "10.1038/s41598-023-45346-2", "pmid": "37865685", "labels": {"Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Funder: NordForsk": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10590404"}, {"db": "pii", "key": "10.1038/s41598-023-45346-2"}, {"db": "ClinicalTrials.gov", "key": "NCT04316884"}, {"db": "ClinicalTrials.gov", "key": "NCT04864938"}, {"db": "ClinicalTrials.gov", "key": "NCT04474249"}], "notes": [], "created": "2023-11-01T13:32:33.866Z", "modified": "2023-11-02T07:09:16.017Z"}, {"entity": "publication", "iuid": "c6d57c9e348f451a85788e6e02f86cc5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c6d57c9e348f451a85788e6e02f86cc5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c6d57c9e348f451a85788e6e02f86cc5"}}, "title": "Sex-stratified patterns of emergency cardiovascular admissions prior and during the COVID-19 pandemic.", "authors": [{"family": "Gajewski", "given": "Piotr", "initials": "P"}, {"family": "B\u0142aziak", "given": "Miko\u0142aj", "initials": "M"}, {"family": "Urban", "given": "Szymon", "initials": "S"}, {"family": "Garus", "given": "Mateusz", "initials": "M"}, {"family": "Braunschweig", "given": "Frieder", "initials": "F"}, {"family": "Caldeira", "given": "Daniel", "initials": "D"}, {"family": "Gawor", "given": "Antoni", "initials": "A"}, {"family": "Greenwood", "given": "John P", "initials": "JP"}, {"family": "Guzik", "given": "Mateusz", "initials": "M"}, {"family": "Halfwerk", "given": "Frank R", "initials": "FR"}, {"family": "Iwanek", "given": "Gracjan", "initials": "G"}, {"family": "Jarocki", "given": "Micha\u0142", "initials": "M"}, {"family": "Jura", "given": "Maksym", "initials": "M"}, {"family": "Krzystek-Korpacka", "given": "Ma\u0142gorzata", "initials": "M"}, {"family": "Lewandowski", "given": "\u0141ukasz", "initials": "\u0141"}, {"family": "Lund", "given": "Lars H", "initials": "LH"}, {"family": "Matysiak", "given": "Micha\u0142", "initials": "M"}, {"family": "Pinto", "given": "Fausto", "initials": "F"}, {"family": "Sleziak", "given": "Jakub", "initials": "J"}, {"family": "Wietrzyk", "given": "Weronika", "initials": "W"}, {"family": "Sokolski", "given": "Mateusz", "initials": "M"}, {"family": "Biegus", "given": "Jan", "initials": "J"}, {"family": "Ponikowski", "given": "Piotr", "initials": "P"}, {"family": "Zymli\u0144ski", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2023-10-20", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "17924"}, "abstract": "The COVID-19 pandemic has had a significant impact on global public health, with long-term consequences that are still largely unknown. This study aimed to assess the data regarding acute cardiovascular hospital admissions in five European centers before and during the pandemic. A multicenter, multinational observational registry was created, comparing admissions to the emergency departments during a 3-months period in 2020 (during the pandemic) with the corresponding period in 2019 (pre-pandemic). Data on patient demographics, COVID-19 test results, primary diagnosis, comorbidities, heart failure profile, medication use, and laboratory results were collected. A total of 8778 patients were included in the analysis, with 4447 patients in 2019 and 4331 patients in 2020. The results showed significant differences in the distribution of cardiovascular diseases between the two years. The frequency of pulmonary embolism (PE) increased in 2020 compared to 2019, while acute heart failure (AHF) and other cardiovascular diseases decreased. The odds of PE incidence among hospitalized patients in 2020 were 1.316-fold greater than in 2019. The incidence of AHF was 50.83% less likely to be observed in 2020, and the odds for other cardiovascular diseases increased by 17.42% between the 2 years. Regarding acute coronary syndrome (ACS), the distribution of its types differed between 2019 and 2020, with an increase in the odds of ST-segment elevation myocardial infarction (STEMI) in 2020. Stratification based on sex revealed further insights. Among men, the incidence of AHF decreased in 2020, while other cardiovascular diseases increased. In women, only the incidence of STEMI showed a significant increase. When analyzing the influence of SARS-CoV-2 infection, COVID-positive patients had a higher incidence of PE compared to COVID-negative patients. COVID-positive patients with ACS also exhibited symptoms of heart failure more frequently than COVID-negative patients. These findings provide valuable information on the impact of the COVID-19 pandemic on acute cardiovascular hospital admissions. The increased incidence of PE and changes in the distribution of other cardiovascular diseases highlight the importance of monitoring and managing cardiovascular health during and post pandemic period. The differences observed between sexes emphasize the need for further research to understand potential sex-specific effects of COVID-19 on cardiovascular outcomes.", "doi": "10.1038/s41598-023-44400-3", "pmid": "37864029", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10589214"}, {"db": "pii", "key": "10.1038/s41598-023-44400-3"}], "notes": [], "created": "2023-11-01T13:31:59.668Z", "modified": "2023-11-01T13:52:38.607Z"}, {"entity": "publication", "iuid": "fe14e3f765754e81884374580c4787b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fe14e3f765754e81884374580c4787b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fe14e3f765754e81884374580c4787b9"}}, "title": "Presence of MDSC associates with impaired antigen-specific T cell reactivity following COVID-19 vaccination in cirrhotic patients.", "authors": [{"family": "T\u00f6rnell", "given": "Andreas", "initials": "A"}, {"family": "Blick", "given": "Elin", "initials": "E"}, {"family": "Al-Dury", "given": "Samer", "initials": "S"}, {"family": "Grauers Wiktorin", "given": "Hanna", "initials": "H"}, {"family": "Waern", "given": "Johan", "initials": "J"}, {"family": "Ringlander", "given": "Johan", "initials": "J"}, {"family": "Einarsdottir", "given": "Sigrun", "initials": "S"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Martner", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2023-10-20", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "1287287"}, "abstract": "Cirrhosis entails high risk of serious infections and abated efficiency of vaccination, but the underlying mechanisms are only partially understood. This study aimed at characterizing innate and adaptive immune functions, including antigen-specific T cell responses to COVID-19 vaccination, in patients with compensated and decompensated cirrhosis.\r\n\r\nImmune phenotype and function in peripheral blood from 42 cirrhotic patients and 44 age-matched healthy controls were analysed after two doses of the mRNA-based COVID-19 vaccines [BNT162b2 (Pfizer BioNTech) or mRNA-1273 (Moderna)].\r\n\r\nCirrhotic patients showed significantly reduced blood counts of antigen-presenting dendritic cells (DC) and high counts of monocytic myeloid-derived suppressor cells (M-MDSC) as compared to healthy controls. In addition, monocytic cells recovered from cirrhotic patients showed impaired expression of the antigen-presenting molecule HLA-DR and the co-stimulatory molecule CD86 upon Toll-like receptor (TLR) stimulation. These features were more prominent in patients with decompensated cirrhosis (Child-Pugh classes B & C). Interestingly, while patients with compensated cirrhosis (Child-Pugh class A) showed an inflammatory profile with myeloid cells producing the proinflammatory cytokines IL-6 and TNF, decompensated patients produced reduced levels of these cytokines. Cirrhotic patients, in particular those with more advanced end-stage liver disease, mounted reduced antigen-specific T cell reactivity to COVID-19 vaccination. Vaccine efficiency inversely correlated with levels of M-MDSC.\r\n\r\nThese results implicate MDSC as mediators of immunosuppression, with ensuing deficiency of vaccine-specific T cell responses, in cirrhosis.", "doi": "10.3389/fimmu.2023.1287287", "pmid": "37928515", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10623131"}], "notes": [], "created": "2023-12-04T07:18:19.150Z", "modified": "2023-12-04T08:08:29.929Z"}, {"entity": "publication", "iuid": "8634058b134c4f2fba1f708de9f6f4d1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8634058b134c4f2fba1f708de9f6f4d1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8634058b134c4f2fba1f708de9f6f4d1"}}, "title": "Exploring the Operational and Technical Changes in the Healthcare Sector During the COVID-19 Pandemic.", "authors": [{"family": "Muzaik", "given": "Suhail", "initials": "S"}, {"family": "Davoody", "given": "Nadia", "initials": "N"}], "type": "journal article", "published": "2023-10-20", "journal": {"title": "Stud Health Technol Inform", "issn": "1879-8365", "issn-l": null, "volume": "309", "issue": null, "pages": "277-281"}, "abstract": "The COVID-19 pandemic has affected the healthcare sector globally including Sweden, creating subsequent operational and technical changes to the wide range of digital healthcare services utilized by healthcare professionals or end consumers. A qualitative study using a self-assessment survey based on the national health services digital maturity assessment was used to study these changes from the perspective of personnel working in Swedish healthcare-related organizations. The number of 30 respondents was selected using purposive sampling, out of them 11 responded. The study highlighted positively perceived changes such as boosting digitalization, improving the procurement process, and introducing crisis management teams. Improving the offered digital services, the tools' effectiveness, efficiency, and technical support were also some of the results. On the contrary, the negatively perceived changes were limiting access to the services, limiting technical support, and reprioritizing non-essential services and projects.", "doi": "10.3233/SHTI230796", "pmid": "37869857", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "SHTI230796"}], "notes": [], "created": "2023-11-01T13:33:54.946Z", "modified": "2023-11-02T07:31:50.682Z"}, {"entity": "publication", "iuid": "f60ebbc57875444e85f44356aacf41f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f60ebbc57875444e85f44356aacf41f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f60ebbc57875444e85f44356aacf41f9"}}, "title": "Dual spatially resolved transcriptomics for human host-pathogen colocalization studies in FFPE tissue sections.", "authors": [{"family": "Sounart", "given": "Hailey", "initials": "H"}, {"family": "L\u00e1z\u00e1r", "given": "Enik\u0151", "initials": "E"}, {"family": "Masarapu", "given": "Yuvarani", "initials": "Y"}, {"family": "Wu", "given": "Jian", "initials": "J"}, {"family": "V\u00e1rkonyi", "given": "Tibor", "initials": "T"}, {"family": "Glasz", "given": "Tibor", "initials": "T"}, {"family": "Kiss", "given": "Andr\u00e1s", "initials": "A"}, {"family": "Borgstr\u00f6m", "given": "Erik", "initials": "E"}, {"family": "Hill", "given": "Andrew", "initials": "A"}, {"family": "Rezene", "given": "Sefanit", "initials": "S"}, {"family": "Gupta", "given": "Soham", "initials": "S"}, {"family": "Jurek", "given": "Aleksandra", "initials": "A"}, {"family": "Niesnerov\u00e1", "given": "Anezka", "initials": "A"}, {"family": "Druid", "given": "Henrik", "initials": "H"}, {"family": "Bergmann", "given": "Olaf", "initials": "O"}, {"family": "Giacomello", "given": "Stefania", "initials": "S", "orcid": "0000-0003-0738-1574", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8bc73b6281054b07880ffbe190731e8b.json"}}], "type": "journal article", "published": "2023-10-19", "journal": {"title": "Genome Biol", "issn": "1474-760X", "issn-l": null, "volume": "24", "issue": "1", "pages": "237"}, "abstract": "Technologies to study localized host-pathogen interactions are urgently needed. Here, we present a spatial transcriptomics approach to simultaneously capture host and pathogen transcriptome-wide spatial gene expression information from human formalin-fixed paraffin-embedded (FFPE) tissue sections at a near single-cell resolution. We demonstrate this methodology in lung samples from COVID-19 patients and validate our spatial detection of SARS-CoV-2 against RNAScope and in situ sequencing. Host-pathogen colocalization analysis identified putative modulators of SARS-CoV-2 infection in human lung cells. Our approach provides new insights into host response to pathogen infection through the simultaneous, unbiased detection of two transcriptomes in FFPE samples.", "doi": "10.1186/s13059-023-03080-y", "pmid": "37858234", "labels": {"Funder: VR": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10588020"}, {"db": "pii", "key": "10.1186/s13059-023-03080-y"}], "notes": [], "created": "2023-11-01T13:31:44.650Z", "modified": "2023-11-01T13:46:37.615Z"}, {"entity": "publication", "iuid": "2f9153d723224d5bbe532af9791850a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2f9153d723224d5bbe532af9791850a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2f9153d723224d5bbe532af9791850a1"}}, "title": "Associations between the COVID-19 pandemic and women's fertility intentions: a multi-country, cross-sectional (I-SHARE) study.", "authors": [{"family": "Zhao", "given": "Min", "initials": "M", "orcid": "0000-0002-2997-2431", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/949b26f15bec49f69f865c784f079101.json"}}, {"family": "O'Hara", "given": "Caitlin Alsandria", "initials": "CA"}, {"family": "Sahril", "given": "Norhafizah Bte", "initials": "NB"}, {"family": "Liu", "given": "Huijun", "initials": "H"}, {"family": "Pei", "given": "Kaiyan", "initials": "K"}, {"family": "Ivanova", "given": "Olena", "initials": "O"}, {"family": "Larsson", "given": "Elin C", "initials": "EC"}, {"family": "Shamu", "given": "Simukai", "initials": "S"}, {"family": "Kpokiri", "given": "Eneyi", "initials": "E"}, {"family": "Cleeve", "given": "Amanda", "initials": "A"}, {"family": "Tucker", "given": "Joseph D", "initials": "JD"}, {"family": "Michielsen", "given": "Kristien", "initials": "K"}, {"family": "Zhang", "given": "Wei-Hong", "initials": "W"}], "type": "journal article", "published": "2023-10-19", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-2009", "issn-l": "2515-1991", "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic, together with the subsequent social distancing measures, could lead to shifts in family and fertility planning. This study aimed to explore the associations between the COVID-19 pandemic and changes in fertility intentions among an international sample of reproductive-aged women.\r\n\r\nA multi-country, cross-sectional study based on data from 10 672 women aged 18-49 years who participated in the International Sexual Health And REproductive Health (I-SHARE) study, which organised an international online survey between July 2020 and February 2021. Factors associated with changes in fertility intentions were explored using multinomial probit regression models. Cluster-robust standard errors were used to calculate model parameters.\r\n\r\nOf 10 672 included reproductive-aged women, 14.4% reported changing their fertility intentions due to the pandemic, with 10.2% postponement and 4.2% acceleration. Women who had ever been isolated/quarantined were more likely to postpone their fertility intentions (adjusted odds ratio (AOR)=1.41; 95% CI 1.18 to 1.69) compared with those who had not; women who lived with a steady partner were more likely to want children sooner (AOR=1.57; 95% CI 1.10 to 2.23) compared with those who did not; and those who reported a higher frequency of getting angry, feeling frustrated, or worrying about their finances were more likely to postpone their fertility intentions. The main findings were robust in the sensitivity analyses.\r\n\r\nMost women who changed fertility intentions because of the pandemic have postponed intentions to expand their families. The pandemic-induced exposures were associated with these postponements.", "doi": "10.1136/bmjsrh-2023-201819", "pmid": "37857464", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjsrh-2023-201819"}], "notes": [], "created": "2023-11-01T13:34:07.164Z", "modified": "2023-11-02T07:41:44.536Z"}, {"entity": "publication", "iuid": "2d38dba1bc134593b8a0bce3328c0c0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d38dba1bc134593b8a0bce3328c0c0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d38dba1bc134593b8a0bce3328c0c0e"}}, "title": "Increased risk of hospitalization, intensive care and death due to COVID-19 in patients with adrenal insufficiency: A Swedish nationwide study.", "authors": [{"family": "Bergthorsdottir", "given": "Ragnhildur", "initials": "R", "orcid": "0000-0002-9535-8632", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eca588e634a2462e9ba1a6558944f240.json"}}, {"family": "Esposito", "given": "Daniela", "initials": "D"}, {"family": "Olsson", "given": "Daniel S", "initials": "DS"}, {"family": "Ragnarsson", "given": "Oskar", "initials": "O", "orcid": "0000-0003-0204-9492", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af4ee421a70e4975885e173d824cbaf2.json"}}, {"family": "Dahlqvist", "given": "Per", "initials": "P"}, {"family": "Bensing", "given": "Sophie", "initials": "S"}, {"family": "N\u00e5tman", "given": "Jonatan", "initials": "J"}, {"family": "Johannsson", "given": "Gudmundur", "initials": "G"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2023-10-18", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Patients with adrenal insufficiency (AI) have excess morbidity and mortality related to infectious disorders. Whether patients with AI have increased morbidity and mortality from COVID-19 is unknown.\r\n\r\nIn this linked Swedish national register-based cohort study, patients with primary and secondary AI diagnosis were identified and followed from 1 January 2020 to 28 February 2021. They were compared with a control cohort from the general population matched 10:1 for age and sex. The following COVID-19 outcomes were studied: incidence of COVID-19 infection, rates of hospitalization, intensive care admission and death. Hazard ratios (HR) with 95% confidence intervals (95% CI) adjusted for socioeconomic factors and comorbidities were estimated using Cox regression analysis.\r\n\r\nWe identified 5430 patients with AI and 54,300 matched controls: There were 47.6% women, mean age was 57.1 (standard deviation 18.1) years, and the frequency of COVID-19 infection was similar, but the frequency of hospitalization (2.1% vs. 0.8%), intensive care (0.3% vs. 0.1%) and death (0.8% vs. 0.2%) for COVID-19 was higher in AI patients than matched controls. After adjustment for socioeconomic factors and comorbidities, the HR (95% CI) was increased for hospitalization (1.96, 1.59-2.43), intensive care admission (2.76, 1.49-5.09) and death (2.29, 1.60-3.28).\r\n\r\nPatients with AI have a similar incidence of COVID-19 infection to a matched control population, but a more than twofold increased risk of developing a severe infection or a fatal outcome. They should therefore be prioritized for vaccination, antiviral therapy and other appropriate treatment to mitigate hospitalization and death.", "doi": "10.1111/joim.13731", "pmid": "37850585", "labels": {"Funder: VR": null, "Funder: Forte": null, "Funder: KAW/SciLifeLab": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:32:09.046Z", "modified": "2023-11-01T13:54:10.428Z"}, {"entity": "publication", "iuid": "5cf9ff158e0c48febb96b8790d6544ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5cf9ff158e0c48febb96b8790d6544ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5cf9ff158e0c48febb96b8790d6544ae"}}, "title": "Age, Successive Waves, Immunization, and Mortality in Elderly COVID-19 Haematological Patients: EPICOVIDEHA Findings.", "authors": [{"family": "Rossi", "given": "Giuseppe", "initials": "G"}, {"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J"}, {"family": "Cattaneo", "given": "Chiara", "initials": "C"}, {"family": "Marchesi", "given": "Francesco", "initials": "F"}, {"family": "D\u00e1vila-Valls", "given": "Julio", "initials": "J"}, {"family": "Mart\u00edn-P\u00e9rez", "given": "Sonia", "initials": "S"}, {"family": "Itri", "given": "Federico", "initials": "F"}, {"family": "L\u00f3pez-Garc\u00eda", "given": "Alberto", "initials": "A"}, {"family": "Glenth\u00f8j", "given": "Andreas", "initials": "A"}, {"family": "Silva", "given": "Maria Gomes DA", "initials": "MGD"}, {"family": "Besson", "given": "Caroline", "initials": "C"}, {"family": "Marchetti", "given": "Monia", "initials": "M"}, {"family": "Weinbergerov\u00e1", "given": "Barbora", "initials": "B"}, {"family": "Jaksic", "given": "Ozren", "initials": "O"}, {"family": "Jim\u00e9nez", "given": "Moraima", "initials": "M"}, {"family": "Bilgin", "given": "Yavuz M", "initials": "YM"}, {"family": "Doesum", "given": "Jaap VAN", "initials": "JV"}, {"family": "Farina", "given": "Francesca", "initials": "F"}, {"family": "\u017d\u00e1k", "given": "Pavel", "initials": "P"}, {"family": "Verga", "given": "Luisa", "initials": "L"}, {"family": "Collins", "given": "Graham P", "initials": "GP"}, {"family": "Bonuomo", "given": "Valentina", "initials": "V"}, {"family": "Praet", "given": "Jens VAN", "initials": "JV"}, {"family": "Nucci", "given": "Marcio", "initials": "M"}, {"family": "Meers", "given": "Stef", "initials": "S"}, {"family": "Espigado", "given": "Ildefonso", "initials": "I"}, {"family": "Fracchiolla", "given": "Nicola S", "initials": "NS"}, {"family": "Valkovi\u0107", "given": "Toni", "initials": "T"}, {"family": "Poulsen", "given": "Christian Bj\u00f8rn", "initials": "CB"}, {"family": "\u010colovi\u0107", "given": "Natasha", "initials": "N"}, {"family": "Dragonetti", "given": "Giulia", "initials": "G"}, {"family": "Ledoux", "given": "Marie-Pierre", "initials": "M"}, {"family": "Tascini", "given": "Carlo", "initials": "C"}, {"family": "Buquicchio", "given": "Caterina", "initials": "C"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Passamonti", "given": "Francesco", "initials": "F"}, {"family": "Machado", "given": "Marina", "initials": "M"}, {"family": "Labrador", "given": "Jorge", "initials": "J"}, {"family": "Duarte", "given": "Rafael F", "initials": "RF"}, {"family": "Sch\u00f6nlein", "given": "Martin", "initials": "M"}, {"family": "Prezioso", "given": "Lucia", "initials": "L"}, {"family": "Falces-Romero", "given": "Iker", "initials": "I"}, {"family": "Kulasekararaj", "given": "Austin", "initials": "A"}, {"family": "Garcia-Vidal", "given": "Carolina", "initials": "C"}, {"family": "Fern\u00e1ndez", "given": "Noem\u00ed", "initials": "N"}, {"family": "Abu-Zeinah", "given": "Ghaith", "initials": "G"}, {"family": "Ormazabal-V\u00e9lez", "given": "Irati", "initials": "I"}, {"family": "Ad\u017ei\u0107-Vuki\u010devi\u0107", "given": "Tatjana", "initials": "T"}, {"family": "Piukovics", "given": "Kl\u00e1ra", "initials": "K"}, {"family": "Stoma", "given": "Igor", "initials": "I"}, {"family": "Cuccaro", "given": "Annarosa", "initials": "A"}, {"family": "Magliano", "given": "Gabriele", "initials": "G"}, {"family": "Szotkowski", "given": "Tom\u00e1\u0161", "initials": "T"}, {"family": "Gonz\u00e1lez-L\u00f3pez", "given": "Tom\u00e1s-Jos\u00e9", "initials": "T"}, {"family": "El-Ashwah", "given": "Shaimaa", "initials": "S"}, {"family": "Bergantim", "given": "Rui", "initials": "R"}, {"family": "Sili", "given": "Uluhan", "initials": "U"}, {"family": "Maertens", "given": "Johan", "initials": "J"}, {"family": "Demirkan", "given": "Fatih", "initials": "F"}, {"family": "Ram\u00f3n", "given": "Cristina DE", "initials": "CD"}, {"family": "Petzer", "given": "Verena", "initials": "V"}, {"family": "Principe", "given": "Maria Ilaria Del", "initials": "MID"}, {"family": "Navr\u00e1til", "given": "Milan", "initials": "M"}, {"family": "Dargenio", "given": "Michelina", "initials": "M"}, {"family": "Seval", "given": "Guldane Cengiz", "initials": "GC"}, {"family": "Samarkos", "given": "Michail", "initials": "M"}, {"family": "R\u00e1\u010dil", "given": "Zden\u011bk", "initials": "Z"}, {"family": "Pincz\u00e9s", "given": "L\u00e1szl\u00f3 Imre", "initials": "LI"}, {"family": "Lahmer", "given": "Tobias", "initials": "T"}, {"family": "Busca", "given": "Alessandro", "initials": "A"}, {"family": "M\u00e9ndez", "given": "Gustavo-Adolfo", "initials": "G"}, {"family": "Vena", "given": "Antonio", "initials": "A"}, {"family": "Biernat", "given": "Monika M", "initials": "MM"}, {"family": "Merelli", "given": "Maria", "initials": "M"}, {"family": "Calbacho", "given": "Maria", "initials": "M"}, {"family": "Bara\u0107", "given": "Aleksandra", "initials": "A"}, {"family": "Bavastro", "given": "Martina", "initials": "M"}, {"family": "Limongelli", "given": "Alessandro", "initials": "A"}, {"family": "Ilhan", "given": "Osman", "initials": "O"}, {"family": "Wolf", "given": "Dominik", "initials": "D"}, {"family": "\u00c7olak", "given": "G\u00f6k\u00e7e Melis", "initials": "GM"}, {"family": "Garc\u00eda-Sanz", "given": "Ram\u00f3n", "initials": "R"}, {"family": "Emarah", "given": "Ziad", "initials": "Z"}, {"family": "Mi\u0161kovi\u0107", "given": "Bojana", "initials": "B"}, {"family": "Gr\u00e4fe", "given": "Stefanie", "initials": "S"}, {"family": "Mladenovi\u0107", "given": "Milo\u0161", "initials": "M"}, {"family": "Aiello", "given": "Tommaso Francesco", "initials": "TF"}, {"family": "N\u00fa\u00f1ez-Mart\u00edn-Buitrago", "given": "Luc\u00eda", "initials": "L"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Arellano", "given": "Elena", "initials": "E"}, {"family": "Zambrotta", "given": "Giovanni Paolo Maria", "initials": "GPM"}, {"family": "Ammatuna", "given": "Emanuele", "initials": "E"}, {"family": "Cabirta", "given": "Alba", "initials": "A"}, {"family": "Sacchi", "given": "Maria Vittoria", "initials": "MV"}, {"family": "Rodrigues", "given": "Raquel Nunes", "initials": "RN"}, {"family": "Hersby", "given": "Ditte Stampe", "initials": "DS"}, {"family": "Hanakova", "given": "Michaela", "initials": "M"}, {"family": "Rahimli", "given": "Laman", "initials": "L"}, {"family": "Cordoba", "given": "Raul", "initials": "R"}, {"family": "Cornely", "given": "Oliver A", "initials": "OA"}, {"family": "Pagano", "given": "Livio", "initials": "L"}], "type": "journal article", "published": "2023-10-18", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": null, "issue": null, "pages": null}, "abstract": "Elderly patients with haematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection impact in different age groups remains unstudied in detail.\r\n\r\nWe analysed elderly patients (age groups: 65-70, 71-75, 76-80 and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with haematological malignancy.\r\n\r\nThe study included data from 3,603 elderly patients (aged 65 or older) with haematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukaemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment.\r\n\r\nThese data underscore the heterogeneity of elderly haematological patients, highlight the different impact of COVID waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts.", "doi": "10.1016/j.ijid.2023.10.013", "pmid": "37863310", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(23)00749-X"}], "notes": [], "created": "2023-11-01T13:33:15.755Z", "modified": "2023-11-02T07:16:55.345Z"}, {"entity": "publication", "iuid": "44585b5eb5754910bf3b4e4c6b78b8b8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44585b5eb5754910bf3b4e4c6b78b8b8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44585b5eb5754910bf3b4e4c6b78b8b8"}}, "title": "SARS-CoV-2 evolution in the Omicron era.", "authors": [{"family": "Roemer", "given": "Cornelius", "initials": "C", "orcid": "0000-0002-6138-6539", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cd1cc85b51147fd8aeef3e206f995b3.json"}}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ", "orcid": "0000-0002-0227-5636", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a612a313d5874131ba64d9811a5d4a08.json"}}, {"family": "Hisner", "given": "Ryan", "initials": "R", "orcid": "0000-0001-8296-9373", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73c65e0c64794ba4a6ada6cf6d927102.json"}}, {"family": "Gueli", "given": "Federico", "initials": "F"}, {"family": "Sakaguchi", "given": "Hitoshi", "initials": "H"}, {"family": "Frohberg", "given": "Nicholas", "initials": "N"}, {"family": "Schoenmakers", "given": "Josette", "initials": "J"}, {"family": "Sato", "given": "Kenta", "initials": "K"}, {"family": "O'Toole", "given": "\u00c1ine", "initials": "\u00c1", "orcid": "0000-0001-8083-474X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4faf78c4ee04495b98b3fd8ef32a0a78.json"}}, {"family": "Rambaut", "given": "Andrew", "initials": "A", "orcid": "0000-0003-4337-3707", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d25e62e17c243f3ab72304ca504e296.json"}}, {"family": "Pybus", "given": "Oliver G", "initials": "OG"}, {"family": "Ruis", "given": "Christopher", "initials": "C", "orcid": "0000-0003-0977-5534", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02edb07284dc438b883cb404c615942f.json"}}, {"family": "Murrell", "given": "Ben", "initials": "B", "orcid": "0000-0002-0393-4445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60dac9ecf84d4eb3b90fb4ee1298bc52.json"}}, {"family": "Peacock", "given": "Thomas P", "initials": "TP", "orcid": "0000-0001-7077-2928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/940835adb42b431a882f9af9acf166f7.json"}}], "type": "journal article", "published": "2023-10-16", "journal": {"title": "Nat Microbiol", "issn": "2058-5276", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Since SARS-CoV-2 BA.5 (Omicron) emerged and spread in 2022, Omicron lineages have markedly diversified. Here we review the evolutionary trajectories and processes that underpin the emergence of these lineages, and identify the most prevalent sublineages. We discuss the potential origins of second-generation BA.2 lineages. Simple and complex recombination, antigenic drift and convergent evolution have enabled SARS-CoV-2 to accumulate mutations that alter its antigenicity. We also discuss the potential evolutionary trajectories of SARS-CoV-2 in the future.", "doi": "10.1038/s41564-023-01504-w", "pmid": "37845314", "labels": {"Category: Genomics & transcriptomics": null, "Type: Other": null, "Funder: KAW/SciLifeLab": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41564-023-01504-w"}], "notes": [], "created": "2023-11-01T13:33:52.276Z", "modified": "2023-11-02T07:30:16.619Z"}, {"entity": "publication", "iuid": "980940116302415bb1ddd8726ee46d69", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/980940116302415bb1ddd8726ee46d69.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/980940116302415bb1ddd8726ee46d69"}}, "title": "EuCARE-hospitalised study protocol: a cohort study of patients hospitalised with COVID-19 in the EuCARE project.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P"}, {"family": "Varisco", "given": "Benedetta", "initials": "B"}, {"family": "Bai", "given": "Francesca", "initials": "F"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Naucler", "given": "Pontus", "initials": "P"}, {"family": "Pfeifer", "given": "Nico", "initials": "N"}, {"family": "Cozzi-Lepri", "given": "Alessandro", "initials": "A"}, {"family": "Ceccherini-Silberstein", "given": "Francesca", "initials": "F"}, {"family": "Naumovas", "given": "Daniel", "initials": "D"}, {"family": "Drobniewski", "given": "Francis", "initials": "F"}, {"family": "Jensen", "given": "Bj\u00f6rn-Erik Ole", "initials": "BO"}, {"family": "Toscano", "given": "Cristina", "initials": "C"}, {"family": "Parczewski", "given": "Mi\u0142osz", "initials": "M"}, {"family": "Quintanares", "given": "Gibran Horemheb Rubio", "initials": "GHR"}, {"family": "Mwau", "given": "Matilu", "initials": "M"}, {"family": "Pinto", "given": "Jorge A", "initials": "JA"}, {"family": "Incardona", "given": "Francesca", "initials": "F"}, {"family": "Mommo", "given": "Chiara", "initials": "C"}, {"family": "Marchetti", "given": "Giulia", "initials": "G"}], "type": "clinical trial protocol", "published": "2023-10-16", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "issn-l": null, "volume": "23", "issue": "1", "pages": "690"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), can lead to hospitalisation, particularly in elderly, immunocompromised, and non-vaccinated or partially vaccinated individuals. Although vaccination provides protection, the duration of this protection wanes over time. Additional doses can restore immunity, but the influence of viral variants, specific sequences, and vaccine-induced immune responses on disease severity remains unclear. Moreover, the efficacy of therapeutic interventions during hospitalisation requires further investigation. The study aims to analyse the clinical course of COVID-19 in hospitalised patients, taking into account SARS-CoV-2 variants, viral sequences, and the impact of different vaccines. The primary outcome is all-cause in-hospital mortality, while secondary outcomes include admission to intensive care unit and length of stay, duration of hospitalisation, and the level of respiratory support required.\r\n\r\nThis ongoing multicentre study observes hospitalised adult patients with confirmed SARS-CoV-2 infection, utilising a combination of retrospective and prospective data collection. It aims to gather clinical and laboratory variables from around 35,000 patients, with potential for a larger sample size. Data analysis will involve biostatistical and machine-learning techniques. Selected patients will provide biological material. The study started on October 14, 2021 and is scheduled to end on October 13, 2026.\r\n\r\nThe analysis of a large sample of retrospective and prospective data about the acute phase of SARS CoV-2 infection in hospitalised patients, viral variants and vaccination in several European and non-European countries will help us to better understand risk factors for disease severity and the interplay between SARS CoV-2 variants, immune responses and vaccine efficacy. The main strengths of this study are the large sample size, the long study duration covering different waves of COVID-19 and the collection of biological samples that allows future research.\r\n\r\nThe trial has been registered on ClinicalTrials.gov. The unique identifier assigned to this trial is NCT05463380.", "doi": "10.1186/s12879-023-08658-2", "pmid": "37845624", "labels": {"Category: Health": null, "Funder: H2020": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10580565"}, {"db": "pii", "key": "10.1186/s12879-023-08658-2"}, {"db": "ClinicalTrials.gov", "key": "NCT05463380"}], "notes": [], "created": "2023-11-01T13:31:41.491Z", "modified": "2023-11-01T13:45:05.813Z"}, {"entity": "publication", "iuid": "2045217c9d5b4df2968b59d7905ac27e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2045217c9d5b4df2968b59d7905ac27e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2045217c9d5b4df2968b59d7905ac27e"}}, "title": "Design, structure and plasma binding of ancestral \u03b2-CoV scaffold antigens.", "authors": [{"family": "Hueting", "given": "David", "initials": "D"}, {"family": "Schriever", "given": "Karen", "initials": "K", "orcid": "0000-0002-3677-5508", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/437c22b7bd0344bfa62968e70d0a9ddf.json"}}, {"family": "Sun", "given": "Rui", "initials": "R"}, {"family": "Vlachiotis", "given": "Stelios", "initials": "S"}, {"family": "Zuo", "given": "Fanglei", "initials": "F", "orcid": "0000-0002-4545-1265", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11312f803b4f49d6be77684a634b0caf.json"}}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Persson", "given": "Helena", "initials": "H"}, {"family": "Hofstr\u00f6m", "given": "Camilla", "initials": "C"}, {"family": "Ohlin", "given": "Mats", "initials": "M", "orcid": "0000-0002-5105-1938", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/def6c0678dfd48ea9a1255a8a00e7ebc.json"}}, {"family": "Walld\u00e9n", "given": "Karin", "initials": "K"}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Marcotte", "given": "Harold", "initials": "H", "orcid": "0000-0002-7168-349X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e05b7b044674cc08cd2269ccf8c076e.json"}}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q", "orcid": "0000-0003-1990-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94a32366862b470eba3a15521b9be290.json"}}, {"family": "Andr\u00e9ll", "given": "Juni", "initials": "J", "orcid": "0000-0003-2313-9155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4088371e089f452783d302617a7fac91.json"}}, {"family": "Syr\u00e9n", "given": "Per-Olof", "initials": "P"}], "type": "journal article", "published": "2023-10-16", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "14", "issue": "1", "pages": "6527"}, "abstract": "We report the application of ancestral sequence reconstruction on coronavirus spike protein, resulting in stable and highly soluble ancestral scaffold antigens (AnSAs). The AnSAs interact with plasma of patients recovered from COVID-19 but do not bind to the human angiotensin-converting enzyme 2 (ACE2) receptor. Cryo-EM analysis of the AnSAs yield high resolution structures (2.6-2.8 \u00c5) indicating a closed pre-fusion conformation in which all three receptor-binding domains (RBDs) are facing downwards. The structures reveal an intricate hydrogen-bonding network mediated by well-resolved loops, both within and across monomers, tethering the N-terminal domain and RBD together. We show that AnSA-5 can induce and boost a broad-spectrum immune response against the wild-type RBD as well as circulating variants of concern in an immune organoid model derived from tonsils. Finally, we highlight how AnSAs are potent scaffolds by replacing the ancestral RBD with the wild-type sequence, which restores ACE2 binding and increases the interaction with convalescent plasma.", "doi": "10.1038/s41467-023-42200-x", "pmid": "37845250", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC10579346"}, {"db": "pii", "key": "10.1038/s41467-023-42200-x"}], "notes": [], "created": "2023-11-01T13:33:34.835Z", "modified": "2023-11-02T14:11:11.290Z"}, {"entity": "publication", "iuid": "9e6701a55fc64fdf88baada957443056", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9e6701a55fc64fdf88baada957443056.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9e6701a55fc64fdf88baada957443056"}}, "title": "Boosted production of antibodies which neutralized different SARS-CoV-2 variants in a COVID-19 convalescent following mRNA vaccination - a case study.", "authors": [{"family": "Ravlo", "given": "Erlend", "initials": "E"}, {"family": "Ianevski", "given": "Aleksandr", "initials": "A"}, {"family": "Starheim", "given": "Eirin", "initials": "E"}, {"family": "Wang", "given": "Wei", "initials": "W"}, {"family": "Ji", "given": "Ping", "initials": "P"}, {"family": "Lysvand", "given": "Hilde", "initials": "H"}, {"family": "Smura", "given": "Teemu", "initials": "T"}, {"family": "Kivi", "given": "Gaily", "initials": "G"}, {"family": "Voolaid", "given": "Maia-Liisa", "initials": "M"}, {"family": "Plaan", "given": "Kati", "initials": "K"}, {"family": "Ustav", "given": "Mart", "initials": "M"}, {"family": "Zusinaite", "given": "Eva", "initials": "E"}, {"family": "Tenson", "given": "Tanel", "initials": "T"}, {"family": "Kurg", "given": "Reet", "initials": "R"}, {"family": "Oksenych", "given": "Valentyn", "initials": "V"}, {"family": "Walstad", "given": "Kirsti", "initials": "K"}, {"family": "Nordb\u00f8", "given": "Svein Arne", "initials": "SA"}, {"family": "Kaarb\u00f8", "given": "Mari", "initials": "M"}, {"family": "Ernits", "given": "Karin", "initials": "K"}, {"family": "Bj\u00f8r\u00e5s", "given": "Magnar", "initials": "M"}, {"family": "Kainov", "given": "Denis E", "initials": "DE"}, {"family": "H\u00f8ys\u00e6ter Fenstad", "given": "Mona", "initials": "M"}], "type": "case reports", "published": "2023-10-16", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": null, "issue": null, "pages": null}, "abstract": "Vaccinated convalescents do not develop severe COVID-19 after infection with new SARS-CoV-2 variants. We questioned how mRNA vaccination of convalescents provides protection from emerging virus variant. From the cohort of 71 convalescent plasma donors, we identified a patient who developed immune response to infection with SARS-CoV-2 variant of 20A clade and who subsequently received mRNA vaccine encoding S protein of strain of 19A clade. We showed that vaccination increased the production of immune cells and anti-S antibodies in the serum. Serum antibodies neutralized not only 19A and 20A, but also 20B, 20H, 21J and 21K virus variants. One of the serum antibodies (100F8) completely neutralized 20A, 21J and partially 21K strains. 100F8 was structurally similarly to published Ab188 antibody, which recognized non-conserved epitope on the S protein. We proposed that 100F8 and other serum antibodies of the patient which recognized non- and conserved epitopes of the S protein, could have additive or synergistic effect to neutralize various virus variants. Thus, mRNA vaccination could be beneficial for convalescents because it boosts production of neutralizing antibodies with broad-spectrum activity. -.", "doi": "10.1016/j.ijid.2023.10.011", "pmid": "37852599", "labels": {"Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(23)00748-8"}], "notes": [], "created": "2023-11-01T13:32:11.722Z", "modified": "2023-11-01T13:55:02.083Z"}, {"entity": "publication", "iuid": "0444ca3518ef4347aed3ff1988d9f5b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0444ca3518ef4347aed3ff1988d9f5b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0444ca3518ef4347aed3ff1988d9f5b2"}}, "title": "Measures against COVID-19 affected the spread of human enteric viruses in a Swedish community, as found when monitoring wastewater.", "authors": [{"family": "Wang", "given": "Hao", "initials": "H"}, {"family": "Churqui", "given": "Marianela Patzi", "initials": "MP"}, {"family": "Tunovic", "given": "Timur", "initials": "T"}, {"family": "Enache", "given": "Lucica", "initials": "L"}, {"family": "Johansson", "given": "Anette", "initials": "A"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Norder", "given": "Hel\u00e9ne", "initials": "H"}], "type": "journal article", "published": "2023-10-15", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "issn-l": "0048-9697", "volume": "895", "issue": null, "pages": "165012"}, "abstract": "The quantification of viral genomes in wastewater reflects the prevalence of viral infections within the community. Knowledge of how the spread of common enteric viruses in the community was affected by the Swedish COVID-19 interventions is limited. To investigate this, the weekly wastewater samples collected for monitoring SARS-CoV-2 throughout the COVID-19 pandemic at the Rya sewage treatment plant in Gothenburg were also analyzed for adenovirus, norovirus GII, astrovirus, and rotavirus. The amount of each viral genome was quantified by real-time-qPCR and compared with the quantity of these viral genomes in wastewater from 2017. The results showed that the winter seasonality of norovirus GII and rotavirus in wastewater observed in 2017 was interrupted shortly after the introduction of the COVID-19 interventions, and they remained at low level throughout the pandemic. The circulation pattern of astrovirus and adenovirus was less affected. When the COVID-19 restrictions were lifted in 2022, a dramatic increase was observed in the amount of norovirus GII, rotavirus, and adenovirus genomes in wastewater. The changes in abundance and seasonality of some viruses identified through wastewater monitoring were consistent with changes in the number of patients diagnosed with these viruses. These findings suggest that moderate intervention to prevent COVID-19 significantly reduced the spread of some enteric viruses in the community. The results show that wastewater monitoring is a valuable tool for detecting the spread and outbreaks of viral infections that may cause gastroenteritis also when people do not seek medical help, such as during the COVID-19 pandemic.", "doi": "10.1016/j.scitotenv.2023.165012", "pmid": "37353026", "labels": {"Category: Public Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10284612"}, {"db": "pii", "key": "S0048-9697(23)03635-5"}], "notes": [], "created": "2023-10-04T09:29:53.367Z", "modified": "2023-10-04T09:41:30.000Z"}, {"entity": "publication", "iuid": "3760d53d668c48d4a6913a27074e84b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3760d53d668c48d4a6913a27074e84b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3760d53d668c48d4a6913a27074e84b9"}}, "title": "Umbilical cord clamping in the early phases of the COVID-19 era - A systematic review and meta-analysis of reported practice and recommendations in guidelines.", "authors": [{"family": "Berg", "given": "Johan", "initials": "J"}, {"family": "Thies-Lagergren", "given": "Li", "initials": "L"}, {"family": "Svedenkrans", "given": "Jenny", "initials": "J"}, {"family": "Samkutty", "given": "Jeremiah", "initials": "J"}, {"family": "Larsson", "given": "Sara Marie", "initials": "SM"}, {"family": "Mercer", "given": "Judith S", "initials": "JS"}, {"family": "Rabe", "given": "Heike", "initials": "H"}, {"family": "Andersson", "given": "Ola", "initials": "O"}, {"family": "Zaigham", "given": "Mehreen", "initials": "M"}], "type": "journal article", "published": "2023-10-13", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": null, "issue": null, "pages": null}, "abstract": "In the beginning of the COVID-19 pandemic, delayed umbilical cord clamping (CC) at birth may have been commonly discouraged despite a lack of convincing evidence of mother-to-neonate SARS-CoV-2 transmission. We aimed to systematically review guidelines, reports of practice and to analyze associations between timing of cord clamping and mother-to-neonate SARS-CoV-2 transmission during the early phases of the pandemic.\r\n\r\nMajor databases were searched December 1, 2019 to July 20, 2021.\r\n\r\nstudies and guidelines describing cord clamping practice in women with SARS-CoV-2 infection during pregnancy until two postnatal days, giving birth to live born neonates.\r\n\r\nno extractable data. Two reviewers independently screened studies for eligibility and assessed study quality. Pooled prevalence rates were calculated.\r\n\r\nForty-eight studies (1476 neonates) and 40 guidelines were included. Delayed CC was recommended in 70.0% of the guidelines. Nevertheless, delayed CC was reported less often than early CC: 262/1476 (17.8%) vs. 511/1476 (34.6%). Neonatal SARS-CoV-2 positivity rates were similar following delayed (1.2%) and early CC (1.3%). Most SARS-CoV-2 transmissions (93.3%) occurred in utero.\r\n\r\nDelayed CC did not seem to increase mother-to-neonate SARS-CoV-2 transmission. Due to its benefits, it should be encouraged even in births where the mother has a SARS-CoV-2 infection.", "doi": "10.1016/j.ijid.2023.10.010", "pmid": "37839504", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(23)00747-6"}], "notes": [], "created": "2023-11-01T13:31:51.574Z", "modified": "2023-11-01T13:49:55.161Z"}, {"entity": "publication", "iuid": "041ca07d2c3b4051a87a5ad6910b6b2f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/041ca07d2c3b4051a87a5ad6910b6b2f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/041ca07d2c3b4051a87a5ad6910b6b2f"}}, "title": "A community effort in SARS-CoV-2 drug discovery.", "authors": [{"family": "Schimunek", "given": "Johannes", "initials": "J"}, {"family": "Seidl", "given": "Philipp", "initials": "P"}, {"family": "Elez", "given": "Katarina", "initials": "K"}, {"family": "Hempel", "given": "Tim", "initials": "T"}, {"family": "Le", "given": "Tuan", "initials": "T"}, {"family": "No\u00e9", "given": "Frank", "initials": "F"}, {"family": "Olsson", "given": "Simon", "initials": "S"}, {"family": "Raich", "given": "Llu\u00eds", "initials": "L"}, {"family": "Winter", "given": "Robin", "initials": "R"}, {"family": "Gokcan", "given": "Hatice", "initials": "H"}, {"family": "Gusev", "given": "Filipp", "initials": "F"}, {"family": "Gutkin", "given": "Evgeny M", "initials": "EM"}, {"family": "Isayev", "given": "Olexandr", "initials": "O"}, {"family": "Kurnikova", "given": "Maria G", "initials": "MG"}, {"family": "Narangoda", "given": "Chamali H", "initials": "CH"}, {"family": "Zubatyuk", "given": "Roman", "initials": "R"}, {"family": "Bosko", "given": "Ivan P", "initials": "IP"}, {"family": "Furs", "given": "Konstantin V", "initials": "KV"}, {"family": "Karpenko", "given": "Anna D", "initials": "AD"}, {"family": "Kornoushenko", "given": "Yury V", "initials": "YV"}, {"family": "Shuldau", "given": "Mikita", "initials": "M"}, {"family": "Yushkevich", "given": "Artsemi", "initials": "A"}, {"family": "Benabderrahmane", "given": "Mohammed", "initials": "M"}, {"family": "Bousquet-Melou", "given": "Patrick", "initials": "P"}, {"family": "Bureau", "given": "Ronan", "initials": "R"}, {"family": "Charton", "given": "Beatrice", "initials": "B"}, {"family": "Cirou", "given": "Bertrand", "initials": "B"}, {"family": "Gil", "given": "G\u00e9rard", "initials": "G"}, {"family": "Allen", "given": "William J", "initials": "WJ"}, {"family": "Sirimulla", "given": "Suman", "initials": "S"}, {"family": "Watowich", "given": "Stanley", "initials": "S"}, {"family": "Antonopoulos", "given": "Nick", "initials": "N"}, {"family": "Epitropakis", "given": "Nikolaos", "initials": "N"}, {"family": "Krasoulis", "given": "Agamemnon", "initials": "A"}, {"family": "Pitsikalis", "given": "Vassilis", "initials": "V"}, {"family": "Theodorakis", "given": "Stavros", "initials": "S"}, {"family": "Kozlovskii", "given": "Igor", "initials": "I"}, {"family": "Maliutin", "given": "Anton", "initials": "A"}, {"family": "Medvedev", "given": "Alexander", "initials": "A"}, {"family": "Popov", "given": "Petr", "initials": "P"}, {"family": "Zaretckii", "given": "Mark", "initials": "M"}, {"family": "Eghbal-Zadeh", "given": "Hamid", "initials": "H"}, {"family": "Halmich", "given": "Christina", "initials": "C"}, {"family": "Hochreiter", "given": "Sepp", "initials": "S"}, {"family": "Mayr", "given": "Andreas", "initials": "A"}, {"family": "Ruch", "given": "Peter", "initials": "P"}, {"family": "Widrich", "given": "Michael", "initials": "M"}, {"family": "Berenger", "given": "Francois", "initials": "F"}, {"family": "Kumar", "given": "Ashutosh", "initials": "A"}, {"family": "Yamanishi", "given": "Yoshihiro", "initials": "Y"}, {"family": "Zhang", "given": "Kam", "initials": "K"}, {"family": "Bengio", "given": "Emmanuel", "initials": "E"}, {"family": "Bengio", "given": "Yoshua", "initials": "Y"}, {"family": "Jain", "given": "Moksh", "initials": "M"}, {"family": "Korablyov", "given": "Maksym", "initials": "M"}, {"family": "Liu", "given": "Cheng-Hao", "initials": "C"}, {"family": "Gilles", "given": "Marcous", "initials": "M"}, {"family": "Glaab", "given": "Enrico", "initials": "E"}, {"family": "Barnsley", "given": "Kelly", "initials": "K"}, {"family": "Iyengar", "given": "Suhasini M", "initials": "SM"}, {"family": "Ondrechen", "given": "Mary Jo", "initials": "MJ"}, {"family": "Haupt", "given": "V Joachim", "initials": "VJ"}, {"family": "Kaiser", "given": "Florian", "initials": "F"}, {"family": "Schroeder", "given": "Michael", "initials": "M"}, {"family": "Pugliese", "given": "Luisa", "initials": "L"}, {"family": "Albani", "given": "Simone", "initials": "S"}, {"family": "Athanasiou", "given": "Christina", "initials": "C"}, {"family": "Beccari", "given": "Andrea", "initials": "A"}, {"family": "Carloni", "given": "Paolo", "initials": "P"}, {"family": "D'Arrigo", "given": "Giulia", "initials": "G"}, {"family": "Gianquinto", "given": "Eleonora", "initials": "E"}, {"family": "Go\u00dfen", "given": "Jonas", "initials": "J"}, {"family": "Hanke", "given": "Anton", "initials": "A"}, {"family": "Joseph", "given": "Benjamin P", "initials": "BP"}, {"family": "Kokh", "given": "Daria B", "initials": "DB"}, {"family": "Kovachka", "given": "Sandra", "initials": "S"}, {"family": "Manelfi", "given": "Candida", "initials": "C"}, {"family": "Mukherjee", "given": "Goutam", "initials": "G"}, {"family": "Mu\u00f1iz-Chicharro", "given": "Abraham", "initials": "A"}, {"family": "Musiani", "given": "Francesco", "initials": "F"}, {"family": "Nunes-Alves", "given": "Ariane", "initials": "A"}, {"family": "Paiardi", "given": "Giulia", "initials": "G"}, {"family": "Rossetti", "given": "Giulia", "initials": "G"}, {"family": "Sadiq", "given": "S Kashif", "initials": "SK"}, {"family": "Spyrakis", "given": "Francesca", "initials": "F"}, {"family": "Talarico", "given": "Carmine", "initials": "C"}, {"family": "Tsengenes", "given": "Alexandros", "initials": "A"}, {"family": "Wade", "given": "Rebecca", "initials": "R"}, {"family": "Copeland", "given": "Conner", "initials": "C"}, {"family": "Gaiser", "given": "Jeremiah", "initials": "J"}, {"family": "Olson", "given": "Daniel R", "initials": "DR"}, {"family": "Roy", "given": "Amitava", "initials": "A"}, {"family": "Venkatraman", "given": "Vishwesh", "initials": "V"}, {"family": "Wheeler", "given": "Travis J", "initials": "TJ"}, {"family": "Arthanari", "given": "Haribabu", "initials": "H"}, {"family": "Blaschitz", "given": "Klara", "initials": "K"}, {"family": "Cespugli", "given": "Marco", "initials": "M"}, {"family": "Durmaz", "given": "Vedat", "initials": "V"}, {"family": "Fackeldey", "given": "Konstantin", "initials": "K"}, {"family": "Fischer", "given": "Patrick D", "initials": "PD"}, {"family": "Gorgulla", "given": "Christoph", "initials": "C"}, {"family": "Gruber", "given": "Christian", "initials": "C"}, {"family": "Gruber", "given": "Karl", "initials": "K"}, {"family": "Hetmann", "given": "Michael", "initials": "M"}, {"family": "Kinney", "given": "Jamie E", "initials": "JE"}, {"family": "Das", "given": "Krishna M Padmanabha", "initials": "KMP"}, {"family": "Pandita", "given": "Shreya", "initials": "S"}, {"family": "Singh", "given": "Amit", "initials": "A"}, {"family": "Steinkellner", "given": "Georg", "initials": "G"}, {"family": "Tesseyre", "given": "Guilhem", "initials": "G"}, {"family": "Wagner", "given": "Gerhard", "initials": "G"}, {"family": "Wang", "given": "Zi-Fu", "initials": "Z"}, {"family": "Yust", "given": "Ryan J", "initials": "RJ"}, {"family": "Druzhilovskiy", "given": "Dmitry S", "initials": "DS"}, {"family": "Filimonov", "given": "Dmitry", "initials": "D"}, {"family": "Pogodin", "given": "Pavel V", "initials": "PV"}, {"family": "Poroikov", "given": "Vladimir", "initials": "V"}, {"family": "Rudik", "given": "Anastassia V", "initials": "AV"}, {"family": "Stolbov", "given": "Leonid A", "initials": "LA"}, {"family": "Veselovsky", "given": "Alexander V", "initials": "AV"}, {"family": "De Rosa", "given": "Maria", "initials": "M"}, {"family": "Simone", "given": "Giada De", "initials": "GD"}, {"family": "Gulotta", "given": "Maria R", "initials": "MR"}, {"family": "Lombino", "given": "Jessica", "initials": "J"}, {"family": "Mekni", "given": "Nedra", "initials": "N"}, {"family": "Perricone", "given": "Ugo", "initials": "U"}, {"family": "Casini", "given": "Arturo", "initials": "A"}, {"family": "Embree", "given": "Amanda", "initials": "A"}, {"family": "Gordon", "given": "D Benjamin", "initials": "DB"}, {"family": "Lei", "given": "David", "initials": "D"}, {"family": "Pratt", "given": "Katelin", "initials": "K"}, {"family": "Voigt", "given": "Christopher A", "initials": "CA"}, {"family": "Chen", "given": "Kuang-Yu", "initials": "K"}, {"family": "Jacob", "given": "Yves", "initials": "Y"}, {"family": "Krischuns", "given": "Tim", "initials": "T"}, {"family": "Lafaye", "given": "Pierre", "initials": "P"}, {"family": "Zettor", "given": "Agn\u00e8s", "initials": "A"}, {"family": "Rodr\u00edguez", "given": "M Luis", "initials": "ML"}, {"family": "White", "given": "Kris M", "initials": "KM"}, {"family": "Fearon", "given": "Daren", "initials": "D"}, {"family": "von Delft", "given": "Frank", "initials": "F"}, {"family": "Walsh", "given": "Martin A", "initials": "MA"}, {"family": "Horvath", "given": "Dragos", "initials": "D"}, {"family": "Brooks", "given": "Charles L", "initials": "CL"}, {"family": "Falsafi", "given": "Babak", "initials": "B"}, {"family": "Ford", "given": "Bryan", "initials": "B"}, {"family": "Garc\u00eda-Sastre", "given": "Adolfo", "initials": "A"}, {"family": "Lee", "given": "Sang Yup", "initials": "SY"}, {"family": "Naffakh", "given": "Nadia", "initials": "N"}, {"family": "Varnek", "given": "Alexandre", "initials": "A"}, {"family": "Klambauer", "given": "Guenter", "initials": "G"}, {"family": "Hermans", "given": "Thomas M", "initials": "TM"}], "type": "journal article", "published": "2023-10-13", "journal": {"title": "Mol Inform", "issn": "1868-1751", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic continues to pose a substantial threat to human lives and is likely to do so for years to come. Despite the availability of vaccines, searching for efficient small-molecule drugs that are widely available, including in low- and middle-income countries, is an ongoing challenge. In this work, we report the results of an open science community effort, the \"Billion molecules against Covid-19 challenge\", to identify small-molecule inhibitors against SARS-CoV-2 or relevant human receptors. Participating teams used a wide variety of computational methods to screen a minimum of 1 billion virtual molecules against 6 protein targets. Overall, 31 teams participated, and they suggested a total of 639,024 molecules, which were subsequently ranked to find 'consensus compounds'. The organizing team coordinated with various contract research organizations (CROs) and collaborating institutions to synthesize and test 878 compounds for biological activity against proteases (Nsp5, Nsp3, TMPRSS2), nucleocapsid N, RdRP (only the Nsp12 domain), and (alpha) spike protein S. Overall, 27 compounds with weak inhibition/binding were experimentally identified by binding-, cleavage-, and/or viral suppression assays and are presented here. Open science approaches such as the one presented here contribute to the knowledge base of future drug discovery efforts in finding better SARS-CoV-2 treatments.", "doi": "10.1002/minf.202300262", "pmid": "37833243", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:31:54.098Z", "modified": "2023-12-08T06:20:32.261Z"}, {"entity": "publication", "iuid": "f28d86a7fc294a118412007f577700be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f28d86a7fc294a118412007f577700be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f28d86a7fc294a118412007f577700be"}}, "title": "Obstetric Intervention and Perinatal Outcomes During the Coronavirus Disease 2019 (COVID-19) Pandemic.", "authors": [{"family": "Simon", "given": "Sophie", "initials": "S"}, {"family": "John", "given": "Sid", "initials": "S"}, {"family": "Lisonkova", "given": "Sarka", "initials": "S"}, {"family": "Razaz", "given": "Neda", "initials": "N"}, {"family": "Muraca", "given": "Giulia M", "initials": "GM"}, {"family": "Boutin", "given": "Am\u00e9lie", "initials": "A"}, {"family": "Bedaiwy", "given": "Mohamed A", "initials": "MA"}, {"family": "Brandt", "given": "Justin S", "initials": "JS"}, {"family": "Ananth", "given": "Cande V", "initials": "CV"}, {"family": "Joseph", "given": "K S", "initials": "KS"}], "type": "journal article", "published": "2023-10-12", "journal": {"title": "Obstet Gynecol", "issn": "1873-233X", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To quantify pandemic-related changes in obstetric intervention and perinatal outcomes in the United States.\r\n\r\nWe carried out a retrospective study of all live births and fetal deaths in the United States, 2015-2021, with data obtained from the natality, fetal death, and linked live birth-infant death files of the National Center for Health Statistics. Analyses were carried out among all singletons; singletons of patients with prepregnancy diabetes, prepregnancy hypertension, and hypertensive disorders of pregnancy; and twins. Outcomes of interest included preterm birth, preterm labor induction or preterm cesarean delivery, macrosomia, postterm birth, and perinatal death. Interrupted time series analyses were used to estimate changes in the prepandemic period (January 2015-February 2020), at pandemic onset (March 2020), and in the pandemic period (March 2020-December 2021).\r\n\r\nThe study population included 26,604,392 live births and 155,214 stillbirths. The prepandemic period was characterized by temporal increases in preterm birth and preterm labor induction or cesarean delivery rates and temporal reductions in macrosomia, postterm birth, and perinatal mortality. Pandemic onset was associated with absolute decreases in preterm birth (decrease of 0.322/100 live births, 95% CI 0.506-0.139) and preterm labor induction or cesarean delivery (decrease of 0.190/100 live births, 95% CI 0.334-0.047) and absolute increases in macrosomia (increase of 0.046/100 live births), postterm birth (increase of 0.015/100 live births), and perinatal death (increase of 0.501/1,000 total births, 95% CI 0.220-0.783). These changes were larger in subpopulations at high risk (eg, among singletons of patients with prepregnancy diabetes). Among singletons of patients with prepregnancy diabetes, pandemic onset was associated with a decrease in preterm birth (decrease of 1.634/100 live births) and preterm labor induction or cesarean delivery (decrease of 1.521/100 live births) and increases in macrosomia (increase of 0.328/100 live births) and perinatal death (increase of 9.840/1,000 total births, 95% CI 3.933-15.75). Most changes were reversed in the months after pandemic onset.\r\n\r\nThe onset of the coronavirus disease 2019 (COVID-19) pandemic was associated with a transient decrease in obstetric intervention (especially preterm labor induction or cesarean delivery) and a transient increase in perinatal mortality.", "doi": "10.1097/AOG.0000000000005412", "pmid": "37826851", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "00006250-990000000-00925"}], "notes": [], "created": "2023-11-01T13:34:24.628Z", "modified": "2023-11-02T07:52:28.666Z"}, {"entity": "publication", "iuid": "1bc095eacf4642b386c0e6e595d6ec1f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1bc095eacf4642b386c0e6e595d6ec1f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1bc095eacf4642b386c0e6e595d6ec1f"}}, "title": "Persistent SARS-CoV-2 infection in patients with B-cell deficiency: a case series of successful antiviral treatment of four patients.", "authors": [{"family": "Fax\u00e9n", "given": "Lisa", "initials": "L"}, {"family": "Edvinsson", "given": "Marie", "initials": "M"}], "type": "case reports", "published": "2023-10-11", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "issn-l": "0300-9734", "volume": "128", "issue": null, "pages": null}, "abstract": "Persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in immunocompromised patients remains a major medical challenge. Diagnosing the syndrome is difficult as symptoms may mimic other diseases and treatment guidelines are lacking. We describe a case series of four patients with persistent SARS-CoV-2 infection that all had an underlying B-cell deficiency due to rituximab treatment (in one case in combination with epcoritamab). In all four patients, it was initially difficult to recognize the persistent disease, leading to a duration of illness between 45 and 242 days. Two patients were only positive for SARS-CoV-2 by polymerase chain reaction (PCR) in the nasopharynx at the beginning of the disease but were later repeatedly negative. However, when bronchoalveolar lavage was performed, a positive SARS-CoV-2 PCR was revealed from the lower airways in both patients. The difficulties establishing diagnosis contributed to these two patients' long disease course. The longest disease duration was in the patient treated with rituximab and epcoritamab, who also responded poorly to single standard antiviral treatment. This patient ultimately cleared the infection after administering a combination treatment with remdesivir and nirmatrelvir/ritonavir. After a confirmed diagnosis, the other three patients cleared the infection when they were finally treated with antivirals. Increasing clinicians' awareness of this condition is important as it might be treatable once diagnosed. Further studies are warranted to define the condition and treatment strategy with greater precision.", "doi": "10.48101/ujms.v128.9807", "pmid": "37849689", "labels": {"Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10578053"}, {"db": "pii", "key": "9807"}], "notes": [], "created": "2023-11-01T13:33:25.248Z", "modified": "2023-11-02T07:20:19.184Z"}, {"entity": "publication", "iuid": "634a7e09497f47248acffc706bc8c203", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/634a7e09497f47248acffc706bc8c203.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/634a7e09497f47248acffc706bc8c203"}}, "title": "Changing patterns in the burden of paediatric injuries during the COVID-19 pandemic: a study in Mozambique's central hospitals.", "authors": [{"family": "Amado", "given": "Vanda", "initials": "V", "orcid": "0000-0002-8839-984X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e564fcb429b45c8932476d0df8d086f.json"}}, {"family": "Trott", "given": "Sebastien", "initials": "S"}, {"family": "M\u00f6ller", "given": "Jette", "initials": "J"}, {"family": "Couto", "given": "Maria Tereza", "initials": "MT"}, {"family": "Wallis", "given": "Lee", "initials": "L"}, {"family": "Laflamme", "given": "Lucie", "initials": "L"}], "type": "journal article", "published": "2023-10-06", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "issn-l": null, "volume": "23", "issue": "1", "pages": "1071"}, "abstract": "There is a substantial body of knowledge on the effects of the COVID-19 pandemic on injuries showing frequent but inconsistent reductions in both volume and pattern. Yet, studies specifically addressing children are less common, not least from low- and middle-income countries. This study investigated whether changes in the pattern and outcome of paediatric injury admissions to Mozambique's four regional referral hospitals during 2020.\r\n\r\nClinical charts of paediatric patients presenting to the targeted hospitals with acute injuries were reviewed using a set of child, injury, and outcome characteristics during each of two consecutive restriction periods in 2020 using as a comparator the same periods in 2019, the year before the pandemic. Differences between 2020 and 2019 proportions for any characteristic were examined using the t-test (significance level 0.05).\r\n\r\nDuring both restriction periods, compared with the previous year, reductions in the number of injuries were noticed in nearly all aspects investigated, albeit more remarkably during the first restriction period, in particular, greater proportions of injuries in the home setting and from burns (7.2% and 11.5% respectively) and a reduced one of discharged patients (by 2.5%).\r\n\r\nDuring the restrictions implemented to contend the pandemic in Mozambique in 2020, although each restriction period saw a drop in the volume of injury admissions at central hospitals, the pattern of child, injury and outcome characteristics did not change much, except for an excess of home and burn injuries in the first, more restrictive period. Whether this reflects the nature of the restrictions only or, rather, other mechanisms that came into play, individual or health systems related, remains to be determined.", "doi": "10.1186/s12913-023-10073-x", "pmid": "37803444", "labels": {"Category: Social Science & Humanities": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10559493"}, {"db": "pii", "key": "10.1186/s12913-023-10073-x"}], "notes": [], "created": "2023-11-01T13:34:09.824Z", "modified": "2023-11-02T07:42:56.476Z"}, {"entity": "publication", "iuid": "0c9b00c1c1354d5a86afaba702538d56", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c9b00c1c1354d5a86afaba702538d56.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c9b00c1c1354d5a86afaba702538d56"}}, "title": "COVID-19 vaccine booster doses provide increased protection against COVID-19 hospitalization compared with previously vaccinated individuals: Interim findings from the REFORCO-Brazil real-world effectiveness study during Delta and Omicron.", "authors": [{"family": "Meeraus", "given": "Wilhelmine", "initials": "W"}, {"family": "Stuurman", "given": "Anke L", "initials": "AL"}, {"family": "Durukal", "given": "Ilgaz", "initials": "I"}, {"family": "Conde-Sousa", "given": "Eduardo", "initials": "E"}, {"family": "Lee", "given": "Andrew", "initials": "A"}, {"family": "Maria", "given": "Andr\u00e9 Santa", "initials": "AS"}, {"family": "Furtado", "given": "B\u00e1rbara Emoingt", "initials": "BE"}, {"family": "Ouwens", "given": "Mario", "initials": "M"}, {"family": "Gray", "given": "Christen M", "initials": "CM"}, {"family": "Valverde", "given": "Douglas Andreas", "initials": "DA"}, {"family": "da Silva", "given": "Hugo Gomes", "initials": "HG"}, {"family": "Taylor", "given": "Sylvia", "initials": "S"}], "type": "journal article", "published": "2023-10-06", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null, "volume": "41", "issue": "42", "pages": "6366-6378"}, "abstract": "Although COVID-19 booster vaccination is widely recommended, there is limited long-term, population-level, real-world evidence on the magnitude of improved protection against severe COVID-19 conferred by boosting with monovalent COVID-19 vaccines developed against ancestral SARS-CoV-2, especially in low- or middle-income countries. We present interim results from the first large-scale assessment of the relative vaccine effectiveness (rVE) of first and second booster doses against severe COVID-19 in a low-/middle-income country.\r\n\r\nREFORCO-Brazil is an ongoing, test-negative case-control study (NCT05697705) utilizing Brazil national severe acute respiratory syndrome (SARS) surveillance and vaccination data. In SARS hospitalizations from August 1, 2021 to July 31, 2022, we matched test-positive (via SARS-CoV-2 antigen/reverse transcription polymerase chain reaction [RT-PCR]) cases and test-negative case-controls (via RT-PCR) based on admission date, preceding vaccinations, and age. We evaluated the rVEs of four monovalent COVID-19 vaccines (AZD1222, Ad26.COV2.S, CoronaVac, and BNT162b2) as second boosters compared with any first boosters received \u22654 months previously, and as first boosters compared with primary-series vaccinations completed \u22654 months previously.\r\n\r\nThe overall rVE of second boosters, from 5668 (2238 test-positive) evaluated hospitalizations, was 24.7 % (95 % confidence interval [CI]: 12.6-35.1); the overall rVE of first boosters, from 30,272 (12,063 test-positive) hospitalizations, was 46.8 % (95 % CI: 43.3-50.0). The rVEs of AZD1222 and BNT162b2 were similar: 29.4 % (95 % CI: 8.6-45.5) and 25.5 % (95 % CI: 4.2-42.2), respectively, for second boosters; and 42.5 % (95 % CI: 28.0-54.0) and 50.8 % (95 % CI: 47.5-54.0), respectively, for first boosters. In general, rVEs were higher in elderly (\u226580 years) and immunocompromised/high-risk individuals.\r\n\r\nOur results support the use of AZD1222 and other adenoviral/mRNA vaccine boosters to maintain protection against COVID-19 hospitalization from Omicron subvariants, including in elderly and immunocompromised individuals at increased risk of accelerated waning or severe outcomes.", "doi": "10.1016/j.vaccine.2023.08.085", "pmid": "37704499", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(23)01051-4"}], "notes": [], "created": "2023-10-06T06:52:27.599Z", "modified": "2023-10-06T09:13:58.218Z"}, {"entity": "publication", "iuid": "cb04059790e140e3aacb27d3654f89c2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cb04059790e140e3aacb27d3654f89c2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cb04059790e140e3aacb27d3654f89c2"}}, "title": "Seizures in hospitalised paediatric patients with SARS-CoV-2 and comparison of severity with seizures in hospitalised paediatric patients with other respiratory viruses during the COVID-19 pandemic: a population-based cohort study.", "authors": [{"family": "Anastasopoulou", "given": "Stavroula", "initials": "S", "orcid": "0000-0002-4210-0064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/649861ba67894cba90ec4340f5bc07a3.json"}}, {"family": "Svensson", "given": "Eva", "initials": "E"}, {"family": "Wickstr\u00f6m", "given": "Ronny", "initials": "R"}, {"family": "Hertting", "given": "Olof", "initials": "O"}, {"family": "Rinder", "given": "Malin Ryd", "initials": "MR"}, {"family": "Bennet", "given": "Rutger", "initials": "R"}, {"family": "Eriksson", "given": "Margareta", "initials": "M"}], "type": "journal article", "published": "2023-10-05", "journal": {"title": "Arch Dis Child", "issn": "1468-2044", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To study seizures in patients hospitalised due to SARS-CoV-2 infection, and compare their severity with seizures in patients hospitalised due to other viral respiratory tract infections (RTIs).\r\n\r\nObservational population-based cohort study.\r\n\r\nNorthern Stockholm.\r\n\r\nPatients aged 1 month-18 years hospitalised due to SARS-CoV-2 with and without seizures, and patients of the same age hospitalised due to other viral RTIs with seizures, between 1 March 2020 and 30 June 2022.\r\n\r\nThe prevalence of seizures in hospitalised patients due to SARS-CoV-2, the evaluation of assumed predictors of seizures and the comparison of severity markers in patients with SARS-CoV-2 versus other RTIs.\r\n\r\n32 of 239 included patients (13.4%) admitted due to SARS-CoV-2 infection had seizures. Central nervous system (CNS) disease and the omicron period had significantly increased OR for seizures (OR: 5.12; CI: 2.06 to 12.72 and OR: 3.01; CI: 1.15 to 7.88, respectively). Seizures in patients with SARS-CoV-2 were more common in children older than 5 years (p=0.001), even in the absence of fever (p=0.007), as compared with other viral RTIs. The duration of hospitalisation was longer in patients with seizures due to other viral RTIs (p=0.023). There was no significant difference regarding severity markers of seizures between the two groups.\r\n\r\nCNS disease and the omicron period were risk factors for seizures in patients with SARS-CoV-2, who were older than patients with other RTIs. The severity of seizures was comparable between the two groups; hospitalisation was however longer in patients with other RTIs.", "doi": "10.1136/archdischild-2023-325974", "pmid": "37798081", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "archdischild-2023-325974"}], "notes": [], "created": "2023-11-01T13:32:30.834Z", "modified": "2023-11-02T07:08:08.817Z"}, {"entity": "publication", "iuid": "9c74268f95a24e3ebf847acd863c1c28", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9c74268f95a24e3ebf847acd863c1c28.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9c74268f95a24e3ebf847acd863c1c28"}}, "title": "Extracellular vesicles in plasma and cerebrospinal fluid in patients with COVID-19 and neurological symptoms.", "authors": [{"family": "Taxiarchis", "given": "Apostolos", "initials": "A", "orcid": "0000-0003-2137-715X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c141f0b728747da86c5a682a77eeed3.json"}}, {"family": "Bellander", "given": "Bo-Michael", "initials": "B"}, {"family": "Antovic", "given": "Jovan", "initials": "J"}, {"family": "Soutari", "given": "Nida", "initials": "N"}, {"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Karakoyun", "given": "Can", "initials": "C"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Antovic", "given": "Aleksandra", "initials": "A"}], "type": "journal article", "published": "2023-10-05", "journal": {"title": "Int J Lab Hematol", "issn": "1751-553X", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Increased levels of extracellular vesicles (EVs) are associated with haemostatic disturbances in various clinical settings. However, their role in COVID-19 patients is still not fully clear. In the present study we investigated EVs in plasma from patients with COVID-19 and neurological symptoms in relation to the activation of coagulation.\r\n\r\nNineteen COVID-19 patients with neurological symptoms and twenty-three aged-matched healthy individuals were included. Global coagulation assays were performed and levels of EVs were determined by flow-cytometry in plasma and cerebrospinal fluid (CSF).\r\n\r\nA procoagulant state characterized by significantly increased overall coagulation- (OCP) and overall haemostatic potential (OHP), diminished overall fibrinolytic potential (OFP) together with a denser fibrin structure was found in patients with COVID-19. Flow cytometry revealed elevated levels of plasma circulating EVs derived from neutrophils (MPO+) and platelets (CD61+), as well as EVs expressing phosphatidylserine (PS+) and complement component C5b-9 (TCC+) in patients with COVID-19 compared with controls. The concentrations of PS+, CD61+ and TCC+ EVs were positively correlated with OCP and OHP in COVID-19 patients. Moreover, we identified CD61+, MPO+ and endothelial cell-derived EVs, as well as EVs exposing PS and TCC in the CSF of patients suffering from neurological symptoms during COVID-19.\r\n\r\nThe unique finding in this study was the presence of EVs in the CSF of COVID-19 patients with neurologic manifestations as well as higher expression of complement protein on circulating plasma EVs. EVs may indicate blood-brain barrier damage during SARS-COV-2 infection.", "doi": "10.1111/ijlh.14182", "pmid": "37795549", "labels": {"Funder: KAW/SciLifeLab": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:31:35.468Z", "modified": "2023-11-01T13:42:24.975Z"}, {"entity": "publication", "iuid": "0e323a2c2ff247e589894e18a5dda5f6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e323a2c2ff247e589894e18a5dda5f6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e323a2c2ff247e589894e18a5dda5f6"}}, "title": "Habitual short sleepers with pre-existing medical conditions are at higher risk of Long COVID.", "authors": [{"family": "Berezin", "given": "Linor", "initials": "L"}, {"family": "Waseem", "given": "Rida", "initials": "R"}, {"family": "Merikanto", "given": "Ilona", "initials": "I"}, {"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L"}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Korman", "given": "Maria", "initials": "M"}, {"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "Espie", "given": "Colin", "initials": "C"}, {"family": "Landtblom", "given": "Anne-Marie", "initials": "A"}, {"family": "Penzel", "given": "Thomas", "initials": "T"}, {"family": "Matsui", "given": "Kentaro", "initials": "K"}, {"family": "Hrubos-Str\u00f8m", "given": "Harald", "initials": "H"}, {"family": "Mota-Rolim", "given": "S\u00e9rgio", "initials": "S"}, {"family": "Nadorff", "given": "Michael R", "initials": "MR"}, {"family": "Plazzi", "given": "Giuseppe", "initials": "G"}, {"family": "Reis", "given": "Catia", "initials": "C"}, {"family": "Chan", "given": "Rachel Ngan Yin", "initials": "RNY"}, {"family": "Cunha", "given": "Ana Suely", "initials": "AS"}, {"family": "Yordanova", "given": "Juliana", "initials": "J"}, {"family": "Bjelajac", "given": "Adrijana Koscec", "initials": "AK"}, {"family": "Inoue", "given": "Yuichi", "initials": "Y"}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "Chung", "given": "Frances", "initials": "F"}], "type": "journal article", "published": "2023-10-03", "journal": {"title": "J Clin Sleep Med", "issn": "1550-9397", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Preliminary evidence suggests that the risk of Long COVID is higher among people with pre-existing medical conditions. Based on its proven adjuvant role in immunity, habitual sleep duration may alter the risk for developing Long COVID. The objective of this study was to determine whether the odds of Long COVID are higher amongst those with pre-existing medical conditions, and whether the strength of this association varies by habitual sleep duration.\r\n\r\nUsing data from 13,461 respondents from 16 countries who participated in the 2021 survey based International COVID Sleep Study II (ICOSS II), we studied the associations between habitual sleep duration, pre-existing medical conditions, and Long COVID.\r\n\r\nOf 2,508 individuals who had COVID-19, 61% reported at least one Long COVID symptom. Multivariable logistic regression analysis showed that the risk of having Long COVID was 1.8-fold higher for average-length sleepers (6-9h/night) with pre-existing medical conditions compared to those without pre-existing medical conditions [aOR 1.84 (1.18-2.90), P=0.008]. The risk of Long COVID was 3-fold higher for short sleepers with pre-existing medical conditions [aOR 2.95 (1.04-8.4), P=0.043] and not significantly higher for long sleepers with pre-existing conditions [aOR 2.11 (0.93-4.77), P=0.073] compared to average-length sleepers without pre-existing conditions.\r\n\r\nHabitual short nighttime sleep duration exacerbated the risk of Long COVID in individuals with pre-existing conditions. Restoring nighttime sleep to average duration represents a potentially modifiable behavioral factor to lower the odds of Long COVID for at-risk patients.", "doi": "10.5664/jcsm.10818", "pmid": "37858285", "labels": {"Category: Health": null, "Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:34:19.743Z", "modified": "2023-11-02T07:48:57.999Z"}, {"entity": "publication", "iuid": "8d078daade6a478fabf0a33c296442e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d078daade6a478fabf0a33c296442e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d078daade6a478fabf0a33c296442e7"}}, "title": "A retrospective multicenter cohort study of the association between anti-Factor Xa values and death, thromboembolism, and bleeding in patients with critical COVID-19.", "authors": [{"family": "Jonmarker", "given": "Sandra", "initials": "S", "orcid": "0000-0001-5836-8594", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d28ab27b84f40e2b3d57c91595ece92.json"}}, {"family": "Litorell", "given": "Jacob", "initials": "J"}, {"family": "Alarcon", "given": "Felix", "initials": "F"}, {"family": "Al-Abani", "given": "Kais", "initials": "K", "orcid": "0000-0002-1789-1538", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a63c8ea9d2b4263817a82795ff41e55.json"}}, {"family": "Bj\u00f6rkman", "given": "Sofia", "initials": "S"}, {"family": "Farm", "given": "Maria", "initials": "M", "orcid": "0000-0003-3696-463X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6de1008608a5480e83cad2a4b1148967.json"}}, {"family": "Grip", "given": "Jonathan", "initials": "J", "orcid": "0000-0001-9735-4160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c335d9cd48e4dd4b193b77e61850257.json"}}, {"family": "S\u00f6derberg", "given": "M\u00e5rten", "initials": "M", "orcid": "0000-0002-1043-3630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/947a6a5a9cf840a0ad95685ed3cbff84.json"}}, {"family": "Hollenberg", "given": "Jacob", "initials": "J", "orcid": "0000-0002-3100-9716", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa5fcdb83dfb4b2db965edaa7cdec033.json"}}, {"family": "Wahlin", "given": "Rebecka Rubenson", "initials": "RR", "orcid": "0000-0003-3890-8236", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac398b363ac24711ba64957e9b5d1940.json"}}, {"family": "Kander", "given": "Thomas", "initials": "T", "orcid": "0000-0002-5404-2981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a22b3691ec6c4b8ebe4b4a15ca9e4b02.json"}}, {"family": "Rimling", "given": "Liivi", "initials": "L"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J", "orcid": "0000-0001-8739-7896", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c2fb174ab842c8809900877de8c008.json"}}, {"family": "Joelsson-Alm", "given": "Eva", "initials": "E", "orcid": "0000-0002-9041-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07a091265e654b21bc27fa14b93e4ec0.json"}}, {"family": "Dahlberg", "given": "Martin", "initials": "M", "orcid": "0000-0002-1271-8736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27361cedab254730be4df04b4df64a77.json"}}, {"family": "Cronhjort", "given": "Maria", "initials": "M", "orcid": "0000-0002-0444-8553", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/198af039066341ac8538d5e9b9ea9e32.json"}}], "type": "journal article", "published": "2023-10-02", "journal": {"title": "Thromb J", "issn": "1477-9560", "issn-l": null, "volume": "21", "issue": "1", "pages": "101"}, "abstract": "Patients with critical COVID-19 have a high risk of thromboembolism, but intensified thromboprophylaxis has not been proven beneficial. The activity of low-molecular-weight heparins can be monitored by measuring anti-Factor Xa. We aimed to study the association between anti-Factor Xa values and death, thromboembolism, and bleeding in patients with critical COVID-19.\r\n\r\nThis retrospective cohort study included adult patients with critical COVID-19 admitted to an intensive care unit at three Swedish hospitals between March 2020 and May 2021 with at least one valid peak and/or trough anti-Factor Xa value. Within the peak and trough categories, patients' minimum, median, and maximum values were determined. Logistic regressions with splines were used to assess associations.\r\n\r\nIn total, 408 patients had at least one valid peak and/or trough anti-Factor Xa measurement, resulting in 153 patients with peak values and 300 patients with trough values. Lower peak values were associated with thromboembolism for patients' minimum (p = 0.01), median (p = 0.005) and maximum (p = 0.001) values. No association was seen between peak values and death or bleeding. Higher trough values were associated with death for median (p = 0.03) and maximum (p = 0.002) values and with both bleeding (p = 0.01) and major bleeding (p = 0.02) for maximum values, but there were no associations with thromboembolism.\r\n\r\nMeasuring anti-Factor Xa activity may be relevant for administrating low-molecular-weight heparin to patients with critical COVID-19. Lower peak values were associated with an increased risk of thromboembolism, and higher trough values were associated with an increased risk of death and bleeding. Prospective studies are needed to confirm the results.\r\n\r\nThe study was retrospectively registered at Clinicaltrials.gov, NCT05256524, February 24, 2022.", "doi": "10.1186/s12959-023-00541-z", "pmid": "37784131", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10544466"}, {"db": "pii", "key": "10.1186/s12959-023-00541-z"}, {"db": "ClinicalTrials.gov", "key": "NCT05256524"}], "notes": [], "created": "2023-11-01T13:32:16.871Z", "modified": "2023-11-01T13:57:22.624Z"}, {"entity": "publication", "iuid": "2b4e178db7a44c5688dcaff545589bae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b4e178db7a44c5688dcaff545589bae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b4e178db7a44c5688dcaff545589bae"}}, "title": "Clinical standards for diagnosis, treatment and prevention of post-COVID-19 lung disease.", "authors": [{"family": "Visca", "given": "D", "initials": "D"}, {"family": "Centis", "given": "R", "initials": "R"}, {"family": "Pontali", "given": "E", "initials": "E"}, {"family": "Zampogna", "given": "E", "initials": "E"}, {"family": "Russell", "given": "A-M", "initials": "A"}, {"family": "Migliori", "given": "G B", "initials": "GB"}, {"family": "Andrejak", "given": "C", "initials": "C"}, {"family": "Aro", "given": "M", "initials": "M"}, {"family": "Bayram", "given": "H", "initials": "H"}, {"family": "Berkani", "given": "K", "initials": "K"}, {"family": "Bruchfeld", "given": "J", "initials": "J"}, {"family": "Chakaya", "given": "J M", "initials": "JM"}, {"family": "Chorostowska-Wynimko", "given": "J", "initials": "J"}, {"family": "Crestani", "given": "B", "initials": "B"}, {"family": "Dalcolmo", "given": "M P", "initials": "MP"}, {"family": "D'Ambrosio", "given": "L", "initials": "L"}, {"family": "Dinh-Xuan", "given": "A-T", "initials": "A"}, {"family": "Duong-Quy", "given": "S", "initials": "S"}, {"family": "Fernandes", "given": "C", "initials": "C"}, {"family": "Garc\u00eda-Garc\u00eda", "given": "J-M", "initials": "J"}, {"family": "de Melo Kawassaki", "given": "A", "initials": "A"}, {"family": "Carrozzi", "given": "L", "initials": "L"}, {"family": "Martinez-Garcia", "given": "M A", "initials": "MA"}, {"family": "Martins", "given": "P Carreiro", "initials": "PC"}, {"family": "Mirsaeidi", "given": "M", "initials": "M"}, {"family": "Mohammad", "given": "Y", "initials": "Y"}, {"family": "Naidoo", "given": "R N", "initials": "RN"}, {"family": "Neuparth", "given": "N", "initials": "N"}, {"family": "Sese", "given": "L", "initials": "L"}, {"family": "Silva", "given": "D R", "initials": "DR"}, {"family": "Solovic", "given": "I", "initials": "I"}, {"family": "Sooronbaev", "given": "T M", "initials": "TM"}, {"family": "Spanevello", "given": "A", "initials": "A"}, {"family": "Sverzellati", "given": "N", "initials": "N"}, {"family": "Tanno", "given": "L", "initials": "L"}, {"family": "Tiberi", "given": "S", "initials": "S"}, {"family": "Vasankari", "given": "T", "initials": "T"}, {"family": "Vasarmidi", "given": "E", "initials": "E"}, {"family": "Vitacca", "given": "M", "initials": "M"}, {"family": "Annesi-Maesano", "given": "I", "initials": "I"}], "type": "journal article", "published": "2023-10-01", "journal": {"title": "Int J Tuberc Lung Dis", "issn": "1815-7920", "issn-l": null, "volume": "27", "issue": "10", "pages": "729-741"}, "abstract": "BACKGROUND: The aim of these clinical standards is to provide guidance on 'best practice' care for the diagnosis, treatment and prevention of post-COVID-19 lung disease.METHODS: A panel of international experts representing scientific societies, associations and groups active in post-COVID-19 lung disease was identified; 45 completed a Delphi process. A 5-point Likert scale indicated level of agreement with the draft standards. The final version was approved by consensus (with 100% agreement).RESULTS: Four clinical standards were agreed for patients with a previous history of COVID-19: Standard 1, Patients with sequelae not explained by an alternative diagnosis should be evaluated for possible post-COVID-19 lung disease; Standard 2, Patients with lung function impairment, reduced exercise tolerance, reduced quality of life (QoL) or other relevant signs or ongoing symptoms \u22654 weeks after the onset of first symptoms should be evaluated for treatment and pulmonary rehabilitation (PR); Standard 3, The PR programme should be based on feasibility, effectiveness and cost-effectiveness criteria, organised according to local health services and tailored to an individual patient's needs; and Standard 4, Each patient undergoing and completing PR should be evaluated to determine its effectiveness and have access to a counselling/health education session.CONCLUSION: This is the first consensus-based set of clinical standards for the diagnosis, treatment and prevention of post-COVID-19 lung disease. Our aim is to improve patient care and QoL by guiding clinicians, programme managers and public health officers in planning and implementing a PR programme to manage post-COVID-19 lung disease.", "doi": "10.5588/ijtld.23.0248", "pmid": "37749839", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC10519381"}], "notes": [], "created": "2023-10-06T06:56:22.374Z", "modified": "2023-10-06T11:17:11.963Z"}, {"entity": "publication", "iuid": "8ff5d63b7d214c3ca0b2c2fa34c71790", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ff5d63b7d214c3ca0b2c2fa34c71790.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ff5d63b7d214c3ca0b2c2fa34c71790"}}, "title": "Anxiety and depression played a central role in the COVID-19 mental distress: A network analysis.", "authors": [{"family": "Fico", "given": "Giovanna", "initials": "G"}, {"family": "Oliva", "given": "Vincenzo", "initials": "V"}, {"family": "De Prisco", "given": "Michele", "initials": "M"}, {"family": "Fortea", "given": "Lydia", "initials": "L"}, {"family": "Fortea", "given": "Adriana", "initials": "A"}, {"family": "Gim\u00e9nez-Palomo", "given": "Anna", "initials": "A"}, {"family": "Anmella", "given": "Gerard", "initials": "G"}, {"family": "Hidalgo-Mazzei", "given": "Diego", "initials": "D"}, {"family": "Vazquez", "given": "Mireia", "initials": "M"}, {"family": "Gomez-Ramiro", "given": "Marta", "initials": "M"}, {"family": "Carreras", "given": "Bernat", "initials": "B"}, {"family": "Murru", "given": "Andrea", "initials": "A"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Mortier", "given": "Philippe", "initials": "P"}, {"family": "Vilagut", "given": "Gemma", "initials": "G"}, {"family": "Amigo", "given": "Franco", "initials": "F"}, {"family": "Ferrer", "given": "Montse", "initials": "M"}, {"family": "Garc\u00eda-Mieres", "given": "Helena", "initials": "H"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Alonso", "given": "Jordi", "initials": "J"}], "type": "journal article", "published": "2023-10-01", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "issn-l": null, "volume": "338", "issue": null, "pages": "384-392"}, "abstract": "Psychological, socio-demographics, and clinical factors play an important role in patients with COVID-19, but their relationship is complex. The network approach might be used to disentangle complex interactions in different systems. Using data from a multicentre, cross-sectional, survey among patients with COVID-19 in Spain (July-November 2020), we investigated the network structure of mental disorders symptoms, social support, and psychological resilience, and changes in network structures according to the presence of a pre-existing mental disorder or hospitalization for COVID-19.\r\n\r\nSubjects completed a survey to evaluate sociodemographic characteristics, COVID-19 infection status, resilience, social support, and symptoms of depression, anxiety disorders, post-traumatic stress disorder, panic attacks, and substance use disorder. 2084 patients with COVID-19 were included in the analysis. Network analysis was conducted to evaluate network and bridge centrality, and the network properties were compared between COVID-19 patients with and without a history of lifetime mental disorder, and between hospitalized and non-hospitalized patients.\r\n\r\nGeneralization of our findings may be difficult since differences in network connectivity may exist in different populations or samples.\r\n\r\nAnxiety and depression showed high centrality in patients with COVID-19 and anxiety showed the highest bridge influence in the network. Resilience and social support showed a low influence on mental disorder symptoms. Global network estimations show no statistically significant changes between patients with and without pre-existing mental disorders or between hospitalized and non-hospitalized patients.\r\n\r\nAnxiety might be a key treatment target in patients with COVID-19 since its treatment might prevent other mental health adverse outcomes.", "doi": "10.1016/j.jad.2023.06.034", "pmid": "37336249", "labels": {"Category: Social Science & Humanities": null, "Funder: H2020": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10276655"}, {"db": "pii", "key": "S0165-0327(23)00799-1"}], "notes": [], "created": "2023-10-04T09:31:19.003Z", "modified": "2023-10-04T10:48:42.360Z"}, {"entity": "publication", "iuid": "a9399f5eff8949499e9364604ce29b07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a9399f5eff8949499e9364604ce29b07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a9399f5eff8949499e9364604ce29b07"}}, "title": "The use and access to contraception in Sweden during the COVID-19 pandemic period.", "authors": [{"family": "Envall", "given": "Niklas", "initials": "N", "orcid": "0000-0003-2813-7642", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/374e845be5ee48c89221e0d6d3fd6af6.json"}}, {"family": "Gemzell Danielsson", "given": "Kristina", "initials": "K", "orcid": "0000-0001-6516-1444", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be16fea6bd1042048b8a4008dc005014.json"}}, {"family": "Kopp Kallner", "given": "Helena", "initials": "H", "orcid": "0000-0001-7184-9165", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd943a169d9c47d69749d5831f65a191.json"}}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Eur J Contracept Reprod Health Care", "issn": "1473-0782", "issn-l": null, "volume": "28", "issue": "5", "pages": "275-281"}, "abstract": "Explore perceived access to, the need for, use of, and satisfaction with telemedicine services for contraceptive counselling and prescription-renewal-only during the COVID-19 pandemic, and the impact of the COVID-19 pandemic period on the choice and use of contraceptives.\r\n\r\nInternet-based e-survey of Swedish women of fertile age, 16-49 years.\r\n\r\nIn total, 1016 participants completed the survey. Most participants (69.7%) rated their access to contraceptive services 'as usual'. Among the remaining participants, a higher proportion rated their access as deteriorated (73.4%) compared to improved (26.6%; p < 0.001). In total, 38.0% reported a need for contraceptive counselling, whereof 14.0% had used telemedicine for counselling and reported high satisfaction. Telemedicine for prescription-renewal-only was used by 15.1% of the total population. Two per cent reported use of another contraceptive than their intended, whereof long-acting reversible contraceptives were the most common intended method. The proportion of current contraceptive users was lower than in 2017 (62.4% vs 71.1%, p < 0.001), and current users of long-acting reversible contraception decreased from 30.6% to 19.3% (p < 0.001).\r\n\r\nDuring the COVID-19 pandemic period, most women found their access to contraceptive services unaffected, but more women felt that it had deteriorated than improved. The use of telemedicine was low, and the use of contraception overall fell. Efforts are needed to raise awareness of available services, and TM-provided interventions for maintained quality of care and informed decision-making remain to be evaluated.SHORT CONDENSATIONThe COVID-19 period imposed a change in contraceptive service provision, and efforts are needed to raise awareness of available services, including telemedicine. Access to all contraceptives, including LARCs, is crucial and telemedicine-provided interventions need evaluation.", "doi": "10.1080/13625187.2023.2260516", "pmid": "37902288", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:32:14.142Z", "modified": "2023-11-01T13:56:01.692Z"}, {"entity": "publication", "iuid": "2eab3dd11de845c988ce6eac5a9f9d76", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2eab3dd11de845c988ce6eac5a9f9d76.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2eab3dd11de845c988ce6eac5a9f9d76"}}, "title": "The four domains of the person-centred practice framework from the perspective of critical care nurses in intensive care units during a pandemic.", "authors": [{"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Nordin", "given": "Anna", "initials": "A"}, {"family": "Fredholm", "given": "Angelica", "initials": "A"}, {"family": "Engstr\u00f6m", "given": "\u00c5sa", "initials": "\u00c5"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "issn-l": null, "volume": "78", "issue": null, "pages": "103449"}, "abstract": "The aim was to describe the Person-Centred Practice Framework's four domains (prerequisites, care environment, person-centred processes, and person-centred outcomes) through the perspectives of critical care nurses working in intensive care units during the second year of the COVID-19 pandemic. Furthermore, the aim was to investigate the relationships between prerequisites, care environment, person-centred processes, and person-centred outcomes.\r\n\r\nA cross-sectional study involving questionnaires. Prerequisites were measured using person-related conditions, the care environment by using the Person-Centred Climate Questionnaire-Staff version, the person-centred processes by using the Person-Centred Care Assessment Tool and person-centred outcomes were measured with one question about present health and well-being and by using Self-rated Exhaustion Disorder. Descriptive and analytic statistics were used. Data was collected from July 2021 to November 2021.\r\n\r\nCritical care nurses (n = 217) working in 15 Swedish adult intensive care units.\r\n\r\nParticipants' average length of experience in intensive care units was 14 years, and most participants experienced increased nursing care responsibilities. They perceived the climate as safe but had limitations in terms of its everydayness and community. Participants perceived the organisations both supported and hindered personalized care. Most participants experienced a variety of exhaustion symptoms, and their health had positive relationship with community.\r\n\r\nBy showing how prerequisites, care environment, person-centred process influences critical care nurses' health and well-being, organisations might identify aspects in the work environment that require targeted interventions to reach healthy workplaces.\r\n\r\nTo preserve the health and well-being of critical care nurses and to flourish as humans in their professional roles, they need to interact with and form relationships with their colleagues, patients, and relatives. Organisations should have a person-centred approach for every individual in the workforce to harness each critical care nurses' knowledge and skills for individuals to growth in their roles.", "doi": "10.1016/j.iccn.2023.103449", "pmid": "37169630", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(23)00066-6"}], "notes": [], "created": "2023-10-04T05:12:14.095Z", "modified": "2023-10-04T08:13:38.344Z"}, {"entity": "publication", "iuid": "28090ad69226499a866997ce4999b25f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/28090ad69226499a866997ce4999b25f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/28090ad69226499a866997ce4999b25f"}}, "title": "Social determinants of health and vaccine uptake during the first wave of the COVID-19 pandemic: A systematic review.", "authors": [{"family": "Vardavas", "given": "Constantine", "initials": "C"}, {"family": "Nikitara", "given": "Katerina", "initials": "K"}, {"family": "Aslanoglou", "given": "Katerina", "initials": "K"}, {"family": "Lagou", "given": "Ioanna", "initials": "I"}, {"family": "Marou", "given": "Valia", "initials": "V"}, {"family": "Phalkey", "given": "Revati", "initials": "R"}, {"family": "Leonardi-Bee", "given": "Jo", "initials": "J"}, {"family": "Fernandez", "given": "Esteve", "initials": "E"}, {"family": "Vivilaki", "given": "Victoria", "initials": "V"}, {"family": "Kamekis", "given": "Apostolos", "initials": "A"}, {"family": "Symvoulakis", "given": "Emmanouil", "initials": "E"}, {"family": "Noori", "given": "Teymur", "initials": "T"}, {"family": "Wuerz", "given": "Andrea", "initials": "A"}, {"family": "Suk", "given": "Jonathan E", "initials": "JE"}, {"family": "Deogan", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Prev Med Rep", "issn": "2211-3355", "issn-l": null, "volume": "35", "issue": null, "pages": "102319"}, "abstract": "Social determinants of health significantly impact population health status. The aim of this systematic review was to examine which social vulnerability factors or determinants of health at the individual or county level affected vaccine uptake within the first phase of the vaccination program. We performed a systematic review of peer-reviewed literature published from January 2020 until September 2021 in Medline and Embase (Bagaria et al., 2022) and complemented the review with an assessment of pre-print literature within the same period. We restricted our criteria to studies performed in the EU/UK/EEA/US that report vaccine uptake in the general population as the primary outcome and included various social determinants of health as explanatory variables. This review provides evidence of significant associations between the early phases of vaccination uptake for SARS-CoV-2 and multiple socioeconomic factors including income, poverty, deprivation, race/ethnicity, education and health insurance. The identified associations should be taken into account to increase vaccine uptake in socially vulnerable groups, and to reduce disparities in uptake, in particular within the context of public health preparedness for future pandemics. While further corroboration is needed to explore the generalizability of these findings across the European setting, these results confirm the need to consider vulnerable groups and social determinants of health in the planning and roll-out of SARS-CoV-2 vaccination programs and within the context of future respiratory pandemics.", "doi": "10.1016/j.pmedr.2023.102319", "pmid": "37564118", "labels": {"Category: Public Health": null, "Type: Other": null, "Category: Vaccines": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10410576"}, {"db": "pii", "key": "S2211-3355(23)00210-3"}], "notes": [], "created": "2023-10-05T08:26:56.988Z", "modified": "2023-10-06T05:18:43.511Z"}, {"entity": "publication", "iuid": "f9262871622b4418a92b7fe26ba35003", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f9262871622b4418a92b7fe26ba35003.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f9262871622b4418a92b7fe26ba35003"}}, "title": "Similarities and differences between myocarditis following COVID-19 mRNA vaccine and multiple inflammatory syndrome with cardiac involvement in children.", "authors": [{"family": "Amodio", "given": "Donato", "initials": "D"}, {"family": "Pascucci", "given": "Giuseppe Rubens", "initials": "GR"}, {"family": "Cotugno", "given": "Nicola", "initials": "N"}, {"family": "Rossetti", "given": "Chiara", "initials": "C"}, {"family": "Manno", "given": "Emma Concetta", "initials": "EC"}, {"family": "Pighi", "given": "Chiara", "initials": "C"}, {"family": "Morrocchi", "given": "Elena", "initials": "E"}, {"family": "D'Alessandro", "given": "Annamaria", "initials": "A"}, {"family": "Perrone", "given": "Marco Alfonso", "initials": "MA"}, {"family": "Valentini", "given": "Alessandra", "initials": "A"}, {"family": "Franceschini", "given": "Alessio", "initials": "A"}, {"family": "Chinali", "given": "Marcello", "initials": "M"}, {"family": "Deodati", "given": "Annalisa", "initials": "A"}, {"family": "Azzari", "given": "Chiara", "initials": "C"}, {"family": "Rossi", "given": "Paolo", "initials": "P"}, {"family": "Cianfarani", "given": "Stefano", "initials": "S"}, {"family": "Andreani", "given": "Marco", "initials": "M"}, {"family": "Porzio", "given": "Ottavia", "initials": "O"}, {"family": "Palma", "given": "Paolo", "initials": "P"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Clin Immunol", "issn": "1521-7035", "issn-l": "1521-6616", "volume": "255", "issue": null, "pages": "109751"}, "abstract": "Despite the multiple benefits of vaccination, cardiac adverse Events Following COVID-19 Immunization (c-AEFI) have been reported. These events as well as the severe cardiac involvement reported in Multisystem inflammatory syndrome in children (MIS-C) appear more frequent in young adult males. Herein, we firstly report on the inflammatory profiles of patients experiencing c-AEFI in comparison with age, pubertal age and gender matched MIS-C with cardiac involvement. Proteins related to systemic inflammation were found higher in MIS-C compared to c-AEFI, whereas a higher level in proteins related to myocardial injury was found in c-AEFI. In addition, higher levels of DHEAS, DHEA, and cortisone were found in c-AEFI which persisted at follow-up. No anti-heart muscle and anti-endothelial cell antibodies have been detected. Overall current comparative data showed a distinct inflammatory and androgens profile in c-AEFI patients which results to be well restricted on heart and to persist months after the acute event.", "doi": "10.1016/j.clim.2023.109751", "pmid": "37660743", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S1521-6616(23)00514-4"}], "notes": [], "created": "2023-10-06T06:57:25.920Z", "modified": "2023-10-06T11:44:34.935Z"}, {"entity": "publication", "iuid": "ef42a285208240baa62ce1067842698e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef42a285208240baa62ce1067842698e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef42a285208240baa62ce1067842698e"}}, "title": "SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC).", "authors": [{"family": "Proal", "given": "Amy D", "initials": "AD", "orcid": "0009-0001-9495-8572", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/71ae496981a84b65afae37e357cf914e.json"}}, {"family": "VanElzakker", "given": "Michael B", "initials": "MB"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Bach", "given": "Katie", "initials": "K"}, {"family": "Boribong", "given": "Brittany P", "initials": "BP", "orcid": "0000-0003-1297-6337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb77f79511294f40aca32d51eaf41722.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}, {"family": "Cherry", "given": "Sara", "initials": "S", "orcid": "0000-0003-3956-6610", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ad4bd94f6194d34b799713f6dd29894.json"}}, {"family": "Chertow", "given": "Daniel S", "initials": "DS", "orcid": "0000-0002-1675-1728", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73aa9c5fa5cc484ebb2015a232494c10.json"}}, {"family": "Davies", "given": "Helen E", "initials": "HE", "orcid": "0000-0001-6102-256X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f50576440954cbe858c48cedc8b5965.json"}}, {"family": "Dupont", "given": "Christopher L", "initials": "CL", "orcid": "0000-0002-0896-6542", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7046b17752c5423a9440ad095e12b07a.json"}}, {"family": "Deeks", "given": "Steven G", "initials": "SG"}, {"family": "Eimer", "given": "William", "initials": "W"}, {"family": "Ely", "given": "E Wesley", "initials": "EW"}, {"family": "Fasano", "given": "Alessio", "initials": "A"}, {"family": "Freire", "given": "Marcelo", "initials": "M", "orcid": "0000-0003-4906-7698", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/716676d7968943dab31508c7bd750590.json"}}, {"family": "Geng", "given": "Linda N", "initials": "LN"}, {"family": "Griffin", "given": "Diane E", "initials": "DE"}, {"family": "Henrich", "given": "Timothy J", "initials": "TJ"}, {"family": "Iwasaki", "given": "Akiko", "initials": "A", "orcid": "0000-0002-7824-9856", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1322301ffd9b4e9bb73ade8fd48d3fd3.json"}}, {"family": "Izquierdo-Garcia", "given": "David", "initials": "D"}, {"family": "Locci", "given": "Michela", "initials": "M"}, {"family": "Mehandru", "given": "Saurabh", "initials": "S", "orcid": "0000-0001-9781-2969", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b81ff206ff0442438dc34abdb197326a.json"}}, {"family": "Painter", "given": "Mark M", "initials": "MM", "orcid": "0000-0002-0180-2748", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ec1e890408445f78038bde6f415ae9a.json"}}, {"family": "Peluso", "given": "Michael J", "initials": "MJ"}, {"family": "Pretorius", "given": "Etheresia", "initials": "E"}, {"family": "Price", "given": "David A", "initials": "DA", "orcid": "0000-0001-9416-2737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/734b7fd55fca47f8b00d1281331ef39a.json"}}, {"family": "Putrino", "given": "David", "initials": "D"}, {"family": "Scheuermann", "given": "Richard H", "initials": "RH", "orcid": "0000-0003-1355-892X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e5d8fb69cab46d1a8465f6a9b170d4c.json"}}, {"family": "Tan", "given": "Gene S", "initials": "GS"}, {"family": "Tanzi", "given": "Rudolph E", "initials": "RE", "orcid": "0000-0002-7032-1454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d99336757334246aae0b6ddd36255c2.json"}}, {"family": "VanBrocklin", "given": "Henry F", "initials": "HF"}, {"family": "Yonker", "given": "Lael M", "initials": "LM", "orcid": "0000-0003-1711-8227", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75531a54672a44e7bf7f16d97def6b33.json"}}, {"family": "Wherry", "given": "E John", "initials": "EJ", "orcid": "0000-0003-0477-1956", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8eb744c9e4544fc0b0a7569b48349044.json"}}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Nat Immunol", "issn": "1529-2916", "issn-l": null, "volume": "24", "issue": "10", "pages": "1616-1627"}, "abstract": "Millions of people are suffering from Long COVID or post-acute sequelae of COVID-19 (PASC). Several biological factors have emerged as potential drivers of PASC pathology. Some individuals with PASC may not fully clear the coronavirus SARS-CoV-2 after acute infection. Instead, replicating virus and/or viral RNA-potentially capable of being translated to produce viral proteins-persist in tissue as a 'reservoir'. This reservoir could modulate host immune responses or release viral proteins into the circulation. Here we review studies that have identified SARS-CoV-2 RNA/protein or immune responses indicative of a SARS-CoV-2 reservoir in PASC samples. Mechanisms by which a SARS-CoV-2 reservoir may contribute to PASC pathology, including coagulation, microbiome and neuroimmune abnormalities, are delineated. We identify research priorities to guide the further study of a SARS-CoV-2 reservoir in PASC, with the goal that clinical trials of antivirals or other therapeutics with potential to clear a SARS-CoV-2 reservoir are accelerated.", "doi": "10.1038/s41590-023-01601-2", "pmid": "37667052", "labels": {"Category: Proteins": null, "Category: Post-COVID": null, "Type: Review": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41590-023-01601-2"}], "notes": [], "created": "2023-10-06T06:52:40.952Z", "modified": "2023-10-06T09:52:56.908Z"}, {"entity": "publication", "iuid": "d651eb1d97f847b39b096d2ba9a3e124", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d651eb1d97f847b39b096d2ba9a3e124.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d651eb1d97f847b39b096d2ba9a3e124"}}, "title": "Natural Course of Aortic Stenosis in Older Subjects: Effects of COVID-19.", "authors": [{"family": "Giani", "given": "Anna", "initials": "A"}, {"family": "Xu", "given": "Hong", "initials": "H"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}, {"family": "Fantin", "given": "Francesco", "initials": "F"}, {"family": "Zamboni", "given": "Mauro", "initials": "M"}, {"family": "B\u00e4ck", "given": "Magnus", "initials": "M"}, {"family": "Religa", "given": "Dorota", "initials": "D"}], "type": "observational study", "published": "2023-10-00", "journal": {"title": "J Am Med Dir Assoc", "issn": "1538-9375", "issn-l": null, "volume": "24", "issue": "10", "pages": "1594.e1-1594.e9"}, "abstract": "Both aortic stenosis (AS) and COVID-19 affect the morbidity and mortality burden among older adults. The aim of the study was to examine whether aortic stenosis (AS) affects the prognosis after SARS-CoV-2 infection and whether COVID-19 affects AS prognosis, in a cohort of older adults hospitalized with and without COVID-19.\r\n\r\nObservational study.\r\n\r\nPatients admitted to 9 geriatric clinics in Stockholm from March 2020 to November 2021.\r\n\r\nAS and COVID-19 diagnoses were identified by electronic health records; the outcomes were mortality at 30 days and any time during a median follow-up of 630 days. The associations between AS, COVID-19, and mortality were assessed by using Royston-Parmar models adjusting for age, sex, comorbidities, and admission waves.\r\n\r\nAmong 28,974 patients, 85 had concomitant AS and COVID-19, 529 had only AS, and 5033 had only COVID-19. Both at 30 days and at any time, as compared to patients without, concomitant AS and COVID-19 subjects had a higher mortality rate (438.4 per 100 py, 95% CI 296.2-648.8, and 72.9, 95% CI 53.7-99.0, respectively) and a higher death risk (adjusted HR 5.5, 95% CI 3.7-8.2; and 2.8, 95% CI 2.1-3.9). AS patients presented increased mortality HR both in the presence and absence of COVID-19 at 30 days (1.6, 95% CI 1.1-2.4; and 1.6, 95% CI 1.2-2.2, respectively) and at any time (1.6, 95% CI 1.1-2.1; 1.4, 95% CI 1.2-1.7, respectively).\r\n\r\nAS was a significant mortality risk factor, independent of concomitant COVID-19. Careful AS management should always be pursued, even in acute and post-acute phases of COVID-19.", "doi": "10.1016/j.jamda.2023.07.026", "pmid": "37696497", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1525-8610(23)00715-6"}], "notes": [], "created": "2023-10-06T06:52:25.240Z", "modified": "2023-10-06T09:12:40.597Z"}, {"entity": "publication", "iuid": "de85b64233bf4afc904771cebd31acd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/de85b64233bf4afc904771cebd31acd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/de85b64233bf4afc904771cebd31acd0"}}, "title": "Myoclonus in patients with COVID-19: Findings of autoantibodies against brain structures in cerebrospinal fluid.", "authors": [{"family": "Lindqvist", "given": "Isa", "initials": "I"}, {"family": "Cunningham", "given": "Janet L", "initials": "JL"}, {"family": "Mulder", "given": "Jan", "initials": "J"}, {"family": "Feresiadou", "given": "Amalia", "initials": "A"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Virhammar", "given": "Johan", "initials": "J", "orcid": "0000-0001-9901-2949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9db4ac69a3e8495ea8e71ae60042fa5c.json"}}, {"family": "Kumlien", "given": "Eva", "initials": "E", "orcid": "0000-0002-1952-8791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de1d39588b21438fabae7d27acf4b237.json"}}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Eur J Neurol", "issn": "1468-1331", "issn-l": null, "volume": "30", "issue": "10", "pages": "3142-3148"}, "abstract": "COVID-19 is associated with multiple neurological manifestations. The clinical presentation, trajectory, and treatment response for three cases of myoclonus during COVID-19 infection, with no previous neurological disease, are decsribed.\r\n\r\nAnalysis of cerebrospinal fluid from the cases using indirect immunohistochemistry.\r\n\r\nAntibodies against rodent brain tissue, and similarities in staining patterns were observed, indicating the presence of antineuronal immunoglobulin G autoantibodies targeting astrocytes in the hippocampus.\r\n\r\nOur results demontrate cerebrospinal fluid antineuronal antibodies indicating an an autoimmune involvment in the pathogenesis in COVID-19 associated myoclonus.", "doi": "10.1111/ene.15958", "pmid": "37392418", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:08:31.262Z", "modified": "2023-10-04T12:37:06.510Z"}, {"entity": "publication", "iuid": "d7511b5121ee45ec86cddd07349547ea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d7511b5121ee45ec86cddd07349547ea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d7511b5121ee45ec86cddd07349547ea"}}, "title": "Molnupiravir compared to nirmatrelvir/ritonavir for COVID-19 in high-risk patients with haematological malignancy in Europe. A matched-paired analysis from the EPICOVIDEHA registry.", "authors": [{"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J"}, {"family": "Marchesi", "given": "Francesco", "initials": "F"}, {"family": "Koehler", "given": "Philipp", "initials": "P"}, {"family": "Weinbergerov\u00e1", "given": "Barbora", "initials": "B"}, {"family": "\u010colovi\u0107", "given": "Natasa", "initials": "N"}, {"family": "Falces-Romero", "given": "Iker", "initials": "I"}, {"family": "Buquicchio", "given": "Caterina", "initials": "C"}, {"family": "Farina", "given": "Francesca", "initials": "F"}, {"family": "van Praet", "given": "Jens", "initials": "J"}, {"family": "Biernat", "given": "Monika M", "initials": "MM"}, {"family": "Itri", "given": "Federico", "initials": "F"}, {"family": "Prezioso", "given": "Lucia", "initials": "L"}, {"family": "Tascini", "given": "Carlo", "initials": "C"}, {"family": "Vena", "given": "Antonio", "initials": "A"}, {"family": "Romano", "given": "Alessandra", "initials": "A"}, {"family": "Delia", "given": "Mario", "initials": "M"}, {"family": "D\u00e1vila-Valls", "given": "Julio", "initials": "J"}, {"family": "Mart\u00edn-P\u00e9rez", "given": "Sonia", "initials": "S"}, {"family": "Lavilla-Rubira", "given": "Esperanza", "initials": "E"}, {"family": "Ad\u017ei\u0107-Vuki\u010devi\u0107", "given": "Tatjana", "initials": "T"}, {"family": "Garc\u00eda-Bordallo", "given": "Daniel", "initials": "D"}, {"family": "L\u00f3pez-Garc\u00eda", "given": "Alberto", "initials": "A"}, {"family": "Criscuolo", "given": "Mariana", "initials": "M"}, {"family": "Petzer", "given": "Verena", "initials": "V"}, {"family": "Fracchiolla", "given": "Nicola S", "initials": "NS"}, {"family": "Espigado", "given": "Ildefonso", "initials": "I"}, {"family": "Sili", "given": "Uluhan", "initials": "U"}, {"family": "Meers", "given": "Stef", "initials": "S"}, {"family": "Erben", "given": "Nurettin", "initials": "N"}, {"family": "Cattaneo", "given": "Chiara", "initials": "C"}, {"family": "Tragiannidis", "given": "Athanasios", "initials": "A"}, {"family": "Gavriilaki", "given": "Eleni", "initials": "E"}, {"family": "Sch\u00f6nlein", "given": "Martin", "initials": "M"}, {"family": "Mitrovic", "given": "Mirjana", "initials": "M"}, {"family": "Pantic", "given": "Nikola", "initials": "N"}, {"family": "Merelli", "given": "Maria", "initials": "M"}, {"family": "Labrador", "given": "Jorge", "initials": "J"}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jos\u00e9-\u00c1ngel", "initials": "J"}, {"family": "Glenth\u00f8j", "given": "Andreas", "initials": "A"}, {"family": "Fouquet", "given": "Guillemette", "initials": "G"}, {"family": "Del Principe", "given": "Maria Ilaria", "initials": "MI"}, {"family": "Dargenio", "given": "Michelina", "initials": "M"}, {"family": "Calbacho", "given": "Mar\u00eda", "initials": "M"}, {"family": "Besson", "given": "Caroline", "initials": "C"}, {"family": "Kohn", "given": "Milena", "initials": "M"}, {"family": "Gr\u00e4fe", "given": "Stefanie", "initials": "S"}, {"family": "Hersby", "given": "Ditte Stampe", "initials": "DS"}, {"family": "Arellano", "given": "Elena", "initials": "E"}, {"family": "\u00c7olak", "given": "G\u00f6k\u00e7e Melis", "initials": "GM"}, {"family": "Wolf", "given": "Dominik", "initials": "D"}, {"family": "Marchetti", "given": "Monia", "initials": "M"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Cordoba", "given": "Raul", "initials": "R"}, {"family": "Mi\u0161kovi\u0107", "given": "Bojana", "initials": "B"}, {"family": "Mladenovi\u0107", "given": "Milo\u0161", "initials": "M"}, {"family": "Bavastro", "given": "Martina", "initials": "M"}, {"family": "Limongelli", "given": "Alessandro", "initials": "A"}, {"family": "Rahimli", "given": "Laman", "initials": "L"}, {"family": "Pagano", "given": "Livio", "initials": "L"}, {"family": "Cornely", "given": "Oliver A", "initials": "OA"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Int J Antimicrob Agents", "issn": "1872-7913", "issn-l": null, "volume": "62", "issue": "4", "pages": "106952"}, "abstract": "Molnupiravir and nirmatrelvir/ritonavir are antivirals used to prevent progression to severe SARS-CoV-2 infections and decrease hospitalisation and mortality rates. Nirmatrelvir/ritonavir was authorised in Europe in December 2021, whereas molnupiravir is not yet licensed in Europe as of February 2022. Molnupiravir may be an alternative to nirmatrelvir/ritonavir because it is associated with fewer drug-drug interactions and contraindications. A caveat for molnupiravir is the mode of action induces viral mutations. Mortality rate reduction with molnupiravir was less pronounced than that with nirmatrelvir/ritonavir in patients without haematological malignancy. Little is known about the comparative efficacy of the two drugs in patients with haematological malignancy at high-risk of severe COVID-19. Thus, molnupiravir and nirmatrelvir/ritonavir were compared in a cohort of patients with haematological malignancies.\r\n\r\nClinical data from patients treated with molnupiravir or nirmatrelvir/ritonavir monotherapy for COVID-19 were retrieved from the EPICOVIDEHA registry. Patients treated with molnupiravir were matched by sex, age (\u00b110 years), and severity of baseline haematological malignancy to controls treated with nirmatrelvir/ritonavir.\r\n\r\nA total of 116 patients receiving molnupiravir for the clinical management of COVID-19 were matched to an equal number of controls receiving nirmatrelvir/ritonavir. In each of the groups, 68 (59%) patients were male; with a median age of 64 years (interquartile range [IQR] 53-74) for molnupiravir recipients and 64 years (IQR 54-73) for nirmatrelvir/ritonavir recipients; 56.9% (n=66) of the patients had controlled baseline haematological malignancy, 12.9% (n=15) had stable disease, and 30.2% (n=35) had active disease at COVID-19 onset in each group. During COVID-19 infection, one third of patients from each group were admitted to hospital. Although a similar proportion of patients in the two groups were vaccinated (molnupiravir n=77, 66% vs. nirmatrelvir/ritonavir n=87, 75%), more of those treated with nirmatrelvir/ritonavir had received four vaccine doses (n=27, 23%) compared with those treated with molnupiravir (n=5, 4%) (P<0.001). No differences were detected in COVID-19 severity (P=0.39) or hospitalisation (P=1.0). No statistically significant differences were identified in overall mortality rate (P=0.78) or survival probability (d30 P=0.19, d60 P=0.67, d90 P=0.68, last day of follow up P=0.68). Deaths were either attributed to COVID-19, or the infection was judged by the treating physician to have contributed to death.\r\n\r\nHospitalisation and mortality rates with molnupiravir were comparable to those with nirmatrelvir/ritonavir in high-risk patients with haematological malignancies and COVID-19. Molnupiravir is a plausible alternative to nirmatrelvir/ritonavir for COVID-19 treatment in patients with haematological malignancy.", "doi": "10.1016/j.ijantimicag.2023.106952", "pmid": "37582478", "labels": {"Category: Health": null, "Type: Journal article": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pii", "key": "S0924-8579(23)00231-5"}], "notes": [], "created": "2023-10-05T08:02:33.837Z", "modified": "2023-10-05T08:46:11.473Z"}, {"entity": "publication", "iuid": "25d827196a0f4fc1a51bd72da008cfd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/25d827196a0f4fc1a51bd72da008cfd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/25d827196a0f4fc1a51bd72da008cfd0"}}, "title": "Implementation of a broad public health approach to COVID-19 in Sweden, January 2020 to May 2022.", "authors": [{"family": "Tegnell", "given": "Anders", "initials": "A"}, {"family": "Bess\u00f6", "given": "Anna", "initials": "A"}, {"family": "Bj\u00f6rkholm", "given": "Britta", "initials": "B"}, {"family": "Byfors", "given": "Sara", "initials": "S"}, {"family": "Carlson", "given": "Johan", "initials": "J"}, {"family": "Tegmark Wisell", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "41", "pages": null}, "abstract": "In 2020, the world had to adapt to a pandemic caused by a then novel coronavirus. In addition to its direct impact on morbidity and mortality, the COVID-19 pandemic brought unprecedented control measures and challenges to both individuals and society. Sweden has been seen by many as an outlier in the management of the pandemic. It is therefore of special interest to document the actual management of the pandemic in Sweden during its first 2 years and how public health was affected. In the authors opinion, within the Swedish context, it has been possible to achieve a similar level of effect on mortality and morbidity through recommendations as was achieved through stringent legal measures in comparable countries. This is supported by comparisons of excess mortality that have been published. Furthermore, we see in the available data that the consequences on mental health and living habits were very limited for the majority of the population. Trust in public institutions is high in Sweden, which has been important and is part of the context that made it possible to manage a pandemic with relatively 'soft' measures. We acknowledge challenges in protecting certain vulnerable groups, particularly during the first and second wave.", "doi": "10.2807/1560-7917.ES.2023.28.41.2300063", "pmid": "37824250", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10571492"}], "notes": [], "created": "2023-11-01T13:33:32.026Z", "modified": "2023-11-02T07:23:36.114Z"}, {"entity": "publication", "iuid": "f901d9ad7f8c4b3090a20cf79c347f86", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f901d9ad7f8c4b3090a20cf79c347f86.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f901d9ad7f8c4b3090a20cf79c347f86"}}, "title": "Healthcare workers' experiences of patient safety in the intensive care unit during the COVID-19 pandemic: A multicentre qualitative study.", "authors": [{"family": "Berggren", "given": "Karin", "initials": "K"}, {"family": "Ekstedt", "given": "Mirjam", "initials": "M", "orcid": "0000-0002-4108-391X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd3b314aef4646a5b54fa1132735d1ff.json"}}, {"family": "Joelsson-Alm", "given": "Eva", "initials": "E", "orcid": "0000-0002-9041-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07a091265e654b21bc27fa14b93e4ec0.json"}}, {"family": "Swedberg", "given": "Lena", "initials": "L"}, {"family": "Sackey", "given": "Peter", "initials": "P"}, {"family": "Schandl", "given": "Anna", "initials": "A", "orcid": "0000-0002-3603-1912", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e848555095e546cba3cfcfd8d4609064.json"}}], "type": "multicenter study", "published": "2023-10-00", "journal": {"title": "J Clin Nurs", "issn": "1365-2702", "issn-l": null, "volume": "32", "issue": "19-20", "pages": "7372-7381"}, "abstract": "To describe healthcare workers' experiences of preconditions and patient safety risks in intensive care units during the COVID-19 pandemic.\r\n\r\nHealthcare workers' ability to adapt to changing conditions is crucial to promote patient safety. During the COVID-19 pandemic, healthcare workers' capacity to maintain safe care was challenged and a more in-depth understanding on frontline experiences of patient safety is needed.\r\n\r\nA qualitative descriptive design.\r\n\r\nIndividual interviews were conducted with 29 healthcare workers (nurses, physicians, nurse assistants and physiotherapists) from three Swedish hospitals directly involved in intensive care of COVID-19 patients. Data were analysed with inductive content analysis. Reporting followed the COREQ checklist.\r\n\r\nThree categories were identified. Hazardous changes in working conditions describes patient safety challenges associated with the extreme workload with high stress level. Imperative adaptations induced by changed preconditions for patient safety which include descriptions of safety risks following adaptations related to temporary intensive care facilities, handling shortage of medical equipment and deviations from routines. Safety risks triggered by reorganisation of care describe how the diluted skill-mix and team disruptions exposed patients to safety risks, and that safety performance mostly relied on individual healthcare worker's responsibility.\r\n\r\nThe study suggests that healthcare workers experienced an increase in patient safety risks during the COVID-19 pandemic mainly because the extremely high workload, imperative adaptations, and reorganisation of care regarding skill-mix and teamwork. Patient safety performance relied on the individuals' adaptability and responsibility rather than on system-based safety.\r\n\r\nThis study provides insights on how healthcare workers' experiences can be used as a source of information for recognition of patient safety risks. To improve detection of safety risks during future crises, guidelines on how to approach safety from a system perspective must include healthcare workers' perceptions on safety risks.\r\n\r\nNone in the conceptualisation or design of the study.", "doi": "10.1111/jocn.16793", "pmid": "37291795", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:31:11.760Z", "modified": "2023-10-04T10:45:26.906Z"}, {"entity": "publication", "iuid": "09ec3219c27546cc8c01c94f93fb7933", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/09ec3219c27546cc8c01c94f93fb7933.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/09ec3219c27546cc8c01c94f93fb7933"}}, "title": "GLOBAL RETROSPECTIVE REVIEW OF SEVERE ACUTE RESPIRATORY SYNDROME SARS COV-2 INFECTIONS IN NONDOMESTIC FELIDS: MARCH 2020-FEBRUARY 2021.", "authors": [{"family": "Bartlett", "given": "Susan L", "initials": "SL"}, {"family": "Koeppel", "given": "Katja N", "initials": "KN"}, {"family": "Cushing", "given": "Andrew C", "initials": "AC"}, {"family": "Bellon", "given": "Hugo Fern\u00e1ndez", "initials": "HF"}, {"family": "Almagro", "given": "Vanessa", "initials": "V"}, {"family": "Gyimesi", "given": "Zoltan S", "initials": "ZS"}, {"family": "Thies", "given": "Tammy", "initials": "T"}, {"family": "H\u00e5rd", "given": "Therese", "initials": "T"}, {"family": "Denitton", "given": "Daniel", "initials": "D"}, {"family": "Fox", "given": "Kami Z", "initials": "KZ"}, {"family": "Vodi\u010dka", "given": "Roman", "initials": "R"}, {"family": "Wang", "given": "Leyi", "initials": "L"}, {"family": "Calle", "given": "Paul P", "initials": "PP"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "J Zoo Wildl Med", "issn": "1042-7260", "issn-l": null, "volume": "54", "issue": "3", "pages": "607-616"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in nondomestic felids have been documented in North America, South America, Africa, Europe, and Asia. Between March 2020 and February 2021, at nine institutions across three continents, infection was confirmed in 16 tigers (Panthera tigris), 14 lions (Panthera leo), three snow leopards (Panthera uncia), one cougar (Puma concolor), and one Amur leopard cat (Prionailurus bengalensis euptilurus) ranging from 2 to 21 yr old (average, 10 yr). Infection was suspected in an additional 12 tigers, 4 lions, and 9 cougars. Clinical signs (in order of most to least common) included coughing, ocular and/or nasal discharge, wheezing, sneezing, decreased appetite, lethargy, diarrhea, and vomiting. Most felids recovered uneventfully, but one geriatric tiger with comorbidities developed severe dyspnea and neurologic signs necessitating euthanasia. Clinical signs lasted 1-19 d (average, 8 d); one tiger was asymptomatic. Infection was confirmed by various methods, including antigen tests and/or polymerase chain reaction (PCR) of nasal or oral swabs, tracheal wash, and feces, or virus isolation from feces or tracheal wash. Infection status and resolution were determined by testing nasal swabs from awake animals, fecal PCR, and observation of clinical signs. Shedding of fecal viral RNA was significantly longer than duration of clinical signs. Postinfection seropositivity was confirmed by four institutions including 11 felids (5 lions, 6 tigers). In most instances, asymptomatic or presymptomatic keepers were the presumed or confirmed source of infection, although in some instances the infection source remains uncertain. Almost all infections occurred despite using cloth facemasks and disposable gloves when in proximity to the felids and during food preparation. Although transmission may have occurred during momentary lapses in personal protective equipment compliance, it seems probable that cloth masks are insufficient at preventing transmission of SARS-CoV-2 from humans to nondomestic felids. Surgical or higher grade masks may be warranted when working with nondomestic felids.", "doi": "10.1638/2022-0141", "pmid": "37817628", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:34:22.162Z", "modified": "2023-11-02T07:50:14.136Z"}, {"entity": "publication", "iuid": "1090d3dbe6ed48309de327319b956586", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1090d3dbe6ed48309de327319b956586.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1090d3dbe6ed48309de327319b956586"}}, "title": "Elevated symptoms of depression and anxiety among family members and friends of critically ill COVID-19 patients - an observational study of five cohorts across four countries.", "authors": [{"family": "Lovik", "given": "Anik\u00f3", "initials": "A"}, {"family": "Gonz\u00e1lez-Hij\u00f3n", "given": "Juan", "initials": "J"}, {"family": "Hoffart", "given": "Asle", "initials": "A"}, {"family": "Fawns-Ritchie", "given": "Chloe", "initials": "C"}, {"family": "Magn\u00fasd\u00f3ttir", "given": "Ingibj\u00f6rg", "initials": "I"}, {"family": "Lu", "given": "Li", "initials": "L"}, {"family": "Unnarsd\u00f3ttir", "given": "Anna B\u00e1ra", "initials": "AB"}, {"family": "K\u00e4hler", "given": "Anna K", "initials": "AK"}, {"family": "Campbell", "given": "Archie", "initials": "A"}, {"family": "Hauksd\u00f3ttir", "given": "Arna", "initials": "A"}, {"family": "Chourpiliadis", "given": "Charilaos", "initials": "C"}, {"family": "McCartney", "given": "Daniel L", "initials": "DL"}, {"family": "Thordard\u00f3ttir", "given": "Edda Bj\u00f6rk", "initials": "EB"}, {"family": "Joyce", "given": "Emily E", "initials": "EE"}, {"family": "Frans", "given": "Emma M", "initials": "EM"}, {"family": "Jakobsd\u00f3ttir", "given": "J\u00f3hanna", "initials": "J"}, {"family": "Trogstad", "given": "Lill", "initials": "L"}, {"family": "Andreassen", "given": "Ole A", "initials": "OA"}, {"family": "Magnus", "given": "Per", "initials": "P"}, {"family": "Johnson", "given": "Sverre Urnes", "initials": "SU"}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF"}, {"family": "Aspelund", "given": "Thor", "initials": "T"}, {"family": "Porteous", "given": "David J", "initials": "DJ"}, {"family": "Ask", "given": "Helga", "initials": "H"}, {"family": "Ebrahimi", "given": "Omid V", "initials": "OV"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur Anna", "initials": "UA"}, {"family": "Fang", "given": "Fang", "initials": "F"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "issn-l": null, "volume": "33", "issue": null, "pages": "100733"}, "abstract": "Little is known regarding the mental health impact of having a significant person (family member and/or close friend) with COVID-19 of different severity.\r\n\r\nThe study included five prospective cohorts from four countries (Iceland, Norway, Sweden, and the UK) with self-reported data on COVID-19 and symptoms of depression and anxiety during March 2020-March 2022. We calculated prevalence ratios (PR) of depression and anxiety in relation to having a significant person with COVID-19 and performed a longitudinal analysis in the Swedish cohort to describe temporal patterns.\r\n\r\n162,237 and 168,783 individuals were included in the analysis of depression and anxiety, respectively, of whom 24,718 and 27,003 reported a significant person with COVID-19. Overall, the PR was 1.07 (95% CI: 1.05-1.10) for depression and 1.08 (95% CI: 1.03-1.13) for anxiety in relation to having a significant person with COVID-19. The respective PRs for depression and anxiety were 1.15 (95% CI: 1.08-1.23) and 1.24 (95% CI: 1.14-1.34) if the patient was hospitalized, 1.42 (95% CI: 1.27-1.57) and 1.45 (95% CI: 1.31-1.60) if the patient was ICU-admitted, and 1.34 (95% CI: 1.22-1.46) and 1.36 (95% CI: 1.22-1.51) if the patient died. Individuals with a significant person with hospitalized, ICU-admitted, or fatal COVID-19 showed elevated prevalence of depression and anxiety during the entire year after the COVID-19 diagnosis.\r\n\r\nFamily members and close friends of critically ill COVID-19 patients show persistently elevated prevalence of depressive and anxiety symptoms.\r\n\r\nThis study was primarily supported by NordForsk (COVIDMENT, 105668) and Horizon 2020 (CoMorMent, 847776).", "doi": "10.1016/j.lanepe.2023.100733", "pmid": "37953992", "labels": {"Funder: H2020": null, "Category: Social Science & Humanities": null, "Type: Journal article": null, "Funder: NordForsk": null}, "xrefs": [{"db": "pmc", "key": "PMC10636287"}, {"db": "pii", "key": "S2666-7762(23)00152-7"}], "notes": [], "created": "2023-12-04T07:18:06.279Z", "modified": "2023-12-04T08:01:51.112Z"}, {"entity": "publication", "iuid": "b3b031004380472dab4d6dab50438f3a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b3b031004380472dab4d6dab50438f3a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b3b031004380472dab4d6dab50438f3a"}}, "title": "Effect of the SARS-CoV-2 pandemic on planned and emergency hernia repair in Sweden: a register-based study.", "authors": [{"family": "Ali", "given": "Fathalla", "initials": "F", "orcid": "0000-0002-2090-4563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db5cc2ac937040a497cc3ca444a2b84c.json"}}, {"family": "Sandblom", "given": "Gabriel", "initials": "G"}, {"family": "Fathalla", "given": "Blend", "initials": "B"}, {"family": "Wallin", "given": "G\u00f6ran", "initials": "G"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Hernia", "issn": "1248-9204", "issn-l": null, "volume": "27", "issue": "5", "pages": "1103-1108"}, "abstract": "The COVID-19 has had a profound impact on the health care delivery in Sweden, including deprioritization of benign surgeries during the COVID-19 pandemic. The aim of this study was to assess the effect of COVID-19 pandemic on emergency and planned hernia repair in Sweden.\r\n\r\nData on hernia repairs from January 2016 to December 2021 were retrieved from the Swedish Patient Register using procedural codes. Two groups were formed: COVID-19 group (January 2020-December 2021) and control group (January 2016-December 2019). Demographic data on mean age, gender, and type of hernia were collected.\r\n\r\nThis study showed a weak negative correlation between the number of elective hernia repairs performed each month during the pandemic and the number of emergency repairs carried out during the following 3 months for inguinal hernia repair (p = 0.114) and incisional hernia repair (p = 0.193), whereas there was no correlation for femoral or umbilical hernia repairs.\r\n\r\nThe COVID-19 pandemic had a great impact on planned hernia surgeries in Sweden, but our hypothesis that postponing planned repairs would increase the risk of emergency events was not supported.", "doi": "10.1007/s10029-023-02828-6", "pmid": "37418049", "labels": {"Category: Other": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10533583"}, {"db": "pii", "key": "10.1007/s10029-023-02828-6"}], "notes": [], "created": "2023-10-04T12:08:23.566Z", "modified": "2023-10-04T12:34:22.585Z"}, {"entity": "publication", "iuid": "dfed0a9f25d144c7ae8d1907acc1f19f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dfed0a9f25d144c7ae8d1907acc1f19f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dfed0a9f25d144c7ae8d1907acc1f19f"}}, "title": "Catch-up antibody responses and hybrid immunity in mRNA vaccinated patients at risk of severe COVID-19.", "authors": [{"family": "Al-Dury", "given": "Samer", "initials": "S"}, {"family": "Waldenstr\u00f6m", "given": "Jesper", "initials": "J", "orcid": "0000-0003-2234-0076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/191df8f505f044c28ca294008918db62.json"}}, {"family": "Ringlander", "given": "Johan", "initials": "J", "orcid": "0000-0002-8483-6504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64f85af7dceb436498422e62f1a98c89.json"}}, {"family": "Einarsdottir", "given": "Sigrun", "initials": "S", "orcid": "0000-0003-4756-6805", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cfc4ff4119cd4d1abbbce55d38311147.json"}}, {"family": "Andersson", "given": "Markus", "initials": "M"}, {"family": "Hamah Saed", "given": "Hevar", "initials": "H"}, {"family": "Waern", "given": "Johan", "initials": "J"}, {"family": "Martner", "given": "Anna", "initials": "A", "orcid": "0000-0002-6598-5221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c11a2e719c534772a129782bfb60d35c.json"}}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-6617-5976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7bda9f192dc44c587d8a252ef16516b.json"}}, {"family": "Lagging", "given": "Martin", "initials": "M", "orcid": "0000-0002-7995-3626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f059c2a808c46219b90ea780e413ad9.json"}}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": "55", "issue": "10", "pages": "744-750"}, "abstract": "The immunogenicity of repeated vaccination and hybrid immunity in vulnerable patients remains unclear.\r\n\r\nWe studied the impact of iterative Covid-19 mRNA vaccination and hybrid immunity on antibody levels in immunosuppressed subjects. Patients with liver cirrhosis (n = 38), survivors of allogeneic haematopoietic stem cell transplantation (allo-HSCT) (n = 36) and patients with autoimmune liver disease (n = 14) along with healthy controls (n = 20) were monitored for SARS-CoV-2-S1 IgG after their 1st-3rd vaccine doses, 31 of whom became infected with the Omicron variant after the 2nd dose. Ten uninfected allo-HSCT recipients received an additional 4th vaccine dose.\r\n\r\nUnexpectedly, immunosuppressed patients achieved antibody levels in parity with controls after the 3rd vaccine dose. In all study cohorts, hybrid immunity (effect of vaccination and natural infection) resulted in approximately 10-fold higher antibody levels than vaccine-induced immunity alone.\r\n\r\nThree doses of the Covid-19 mRNA vaccine entailed high antibody concentrations even in immunocompromised individuals, and hybrid-immunity resulted further augmented levels than vaccination alone. Clinical trial registration: EudraCT 2021-000349-42.", "doi": "10.1080/23744235.2023.2230289", "pmid": "37395287", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:07:48.708Z", "modified": "2023-10-04T12:26:01.724Z"}, {"entity": "publication", "iuid": "1930eed8da554f868ccdb3405dceb019", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1930eed8da554f868ccdb3405dceb019.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1930eed8da554f868ccdb3405dceb019"}}, "title": "Access to sexual and reproductive health services among South African young people living with and without HIV during the COVID-19 pandemic.", "authors": [{"family": "Giovenco", "given": "Danielle", "initials": "D"}, {"family": "Pettifor", "given": "Audrey", "initials": "A"}, {"family": "Itzikowitz", "given": "Gina", "initials": "G"}, {"family": "Chung", "given": "Stephanie", "initials": "S"}, {"family": "Qayiya", "given": "Yamkela", "initials": "Y"}, {"family": "K\u0227gesten", "given": "Anna E", "initials": "AE"}, {"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM"}, {"family": "Bekker", "given": "Linda-Gail", "initials": "L"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Contraception", "issn": "1879-0518", "issn-l": null, "volume": "126", "issue": null, "pages": "110119"}, "abstract": "To examine sexual and reproductive health (SRH) service access among South African young people during the COVID-19 pandemic.\r\n\r\nWe utilized cross-sectional data collected from February to October 2021 in Cape Town among young people 13-24 years of age living with and without HIV.\r\n\r\nTwo hundred and fifteen young people living with HIV (YPLWH) and 320 young people living without HIV were included. Young people reported an unmet need for SRH services during COVID-19, and 28% of YPLWH reported missing an HIV care appointment during the COVID-19 lockdowns.\r\n\r\nExpanding access to SRH services for young people during disruptive events is critical to reduce disparities in HIV and other SRH outcomes.", "doi": "10.1016/j.contraception.2023.110119", "pmid": "37467919", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0010-7824(23)00209-3"}], "notes": [], "created": "2023-10-04T12:09:17.106Z", "modified": "2023-10-04T12:50:30.860Z"}, {"entity": "publication", "iuid": "14ceb83c4c3844969152393ee4b41045", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/14ceb83c4c3844969152393ee4b41045.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/14ceb83c4c3844969152393ee4b41045"}}, "title": "A meta-meta-analysis of co-infection, secondary infections, and antimicrobial resistance in COVID-19 patients.", "authors": [{"family": "Suleiman", "given": "Adeiza Shuaibu", "initials": "AS"}, {"family": "Islam", "given": "Md Aminul", "initials": "MA"}, {"family": "Akter", "given": "Mir Salma", "initials": "MS"}, {"family": "Amin", "given": "Mohammad Ruhul", "initials": "MR"}, {"family": "Werkneh", "given": "Adhena Ayaliew", "initials": "AA"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}], "type": "systematic review", "published": "2023-10-00", "journal": {"title": "J Infect Public Health", "issn": "1876-035X", "issn-l": null, "volume": "16", "issue": "10", "pages": "1562-1590"}, "abstract": "The newly discovered coronavirus SARS-CoV-2 has sparked a worldwide pandemic of COVID-19, which has caused havoc on medical infrastructures, economies, and cultures around the world. Determining the whole scenario is essential since SARS-CoV-2 variants and sub-variants keep appearing after vaccinations and booster doses. The objective of this secondary meta-analysis is to analysis co-infection, secondary infections, and antimicrobial resistance (AMR) in COVID-19 patients. This study used five significant databases to conduct a systematic review and an overlap meta-analysis to evaluate the pooled estimates of co-infections and secondary infections. The summary of the meta-analysis showed an overall co-infection effect of 26.19% (95% confidence intervals CI: 21.39-31.01, I2 =98.78, n = 14 meta-analysis) among patients with COVID-19. A coinfection effect of 11.13% (95% CI: 9.7-12.56, I2 =99.14, n = 11 meta-analysis) for bacteria; 9.69% (95% CI: 1.21-7.90, I2 =98.33) for fungal and 3.48% (95% CI: 2.15-4.81, I2 =95.84) for viruses. A secondary infection effect of 19.03% (95% CI: 9.53-28.54, I2 =85.65) was pooled from 2 meta-analyses (Ave: 82 primary studies). This is the first study that compiles the results of all the previous three years meta-analyses into a single source and offers strong proof of co-infections and secondary infections in COVID-19 patients. Early detection of co-infection and AMR is crucial for COVID-19 patients in order to effective treatment.", "doi": "10.1016/j.jiph.2023.07.005", "pmid": "37572572", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1876-0341(23)00240-X"}], "notes": [], "created": "2023-10-05T08:01:54.159Z", "modified": "2023-10-05T08:37:48.264Z"}, {"entity": "publication", "iuid": "5d52e0763b144d49bad1aa7e75f1746a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d52e0763b144d49bad1aa7e75f1746a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d52e0763b144d49bad1aa7e75f1746a"}}, "title": "A comparison of COVID-19 incidence rates across six European countries in 2021.", "authors": [{"family": "Padget", "given": "Michael", "initials": "M"}, {"family": "Adam", "given": "Pauline", "initials": "P"}, {"family": "Dorfmuller", "given": "Marina", "initials": "M"}, {"family": "Blondel", "given": "Clara", "initials": "C"}, {"family": "Campos-Matos", "given": "Ines", "initials": "I"}, {"family": "Fayad", "given": "Myriam", "initials": "M"}, {"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Mesher", "given": "David", "initials": "D"}, {"family": "Pistol", "given": "Adriana", "initials": "A"}, {"family": "Rebolledo", "given": "Javiera", "initials": "J"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Riess", "given": "Maximilian", "initials": "M"}, {"family": "Rusu", "given": "Lavinia Cipriana", "initials": "LC"}, {"family": "Che", "given": "Didier", "initials": "D"}, {"family": "Coignard", "given": "Bruno", "initials": "B"}, {"family": "COVID-19 Study group", "given": "", "initials": ""}, {"family": "COVID-19 Study Group members", "given": "", "initials": ""}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "40", "pages": null}, "abstract": "International comparisons of COVID-19 incidence rates have helped gain insights into the characteristics of the disease, benchmark disease impact, shape public health measures and inform potential travel restrictions and border control measures. However, these comparisons may be biased by differences in COVID-19 surveillance systems and approaches to reporting in each country. To better understand these differences and their impact on incidence comparisons, we collected data on surveillance systems from six European countries: Belgium, England, France, Italy, Romania and Sweden. Data collected included: target testing populations, access to testing, case definitions, data entry and management and statistical approaches to incidence calculation. Average testing, incidence and contextual data were also collected. Data represented the surveillance systems as they were in mid-May 2021. Overall, important differences between surveillance systems were detected. Results showed wide variations in testing rates, access to free testing and the types of tests recorded in national databases, which may substantially limit incidence comparability. By systematically including testing information when comparing incidence rates, these comparisons may be greatly improved. New indicators incorporating testing or existing indicators such as death or hospitalisation will be important to improving international comparisons.", "doi": "10.2807/1560-7917.ES.2023.28.40.2300088", "pmid": "37796443", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10557383"}], "notes": [], "created": "2023-11-01T13:33:22.545Z", "modified": "2023-11-02T07:18:16.856Z"}, {"entity": "publication", "iuid": "9c030619934c4fc3ae03dfc8cdbd0329", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9c030619934c4fc3ae03dfc8cdbd0329.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9c030619934c4fc3ae03dfc8cdbd0329"}}, "title": "Immunogenicity and safety of AZD2816, a beta (B.1.351) variant COVID-19 vaccine, and AZD1222 (ChAdOx1 nCoV-19) as third-dose boosters for previously vaccinated adults: a multicentre, randomised, partly double-blinded, phase 2/3 non-inferiority immunobridging study in the UK and Poland.", "authors": [{"family": "Ramasamy", "given": "Maheshi N", "initials": "MN"}, {"family": "Kelly", "given": "Elizabeth J", "initials": "EJ"}, {"family": "Seegobin", "given": "Seth", "initials": "S"}, {"family": "Dargan", "given": "Paul I", "initials": "PI"}, {"family": "Payne", "given": "Ruth", "initials": "R"}, {"family": "Libri", "given": "Vincenzo", "initials": "V"}, {"family": "Adam", "given": "Matthew", "initials": "M"}, {"family": "Aley", "given": "Parvinder K", "initials": "PK"}, {"family": "Martinez-Alier", "given": "Nuria", "initials": "N"}, {"family": "Church", "given": "Alison", "initials": "A"}, {"family": "Jepson", "given": "Brett", "initials": "B"}, {"family": "Khan", "given": "Mark", "initials": "M"}, {"family": "Matthews", "given": "Sam", "initials": "S"}, {"family": "Townsend", "given": "G Todd", "initials": "GT"}, {"family": "Vekemans", "given": "Johan", "initials": "J"}, {"family": "Bibi", "given": "Sagida", "initials": "S"}, {"family": "Swanson", "given": "Phillip A", "initials": "PA"}, {"family": "Lambe", "given": "Teresa", "initials": "T"}, {"family": "Pangalos", "given": "Menelas N", "initials": "MN"}, {"family": "Villafana", "given": "Tonya", "initials": "T"}, {"family": "Pollard", "given": "Andrew J", "initials": "AJ"}, {"family": "Green", "given": "Justin A", "initials": "JA"}, {"family": "AZD2816 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-09-29", "journal": {"title": "The Lancet Microbe", "issn": "2666-5247", "issn-l": "2666-5247", "volume": null, "issue": null, "pages": null}, "abstract": "This study aimed to evaluate AZD2816, a variant-updated COVID-19 vaccine expressing the full-length SARS-CoV-2 beta (B.1.351) variant spike protein that is otherwise similar to AZD1222 (ChAdOx1 nCoV-19), and AZD1222 as third-dose boosters.\r\n\r\nThis phase 2/3, partly double-blinded, randomised, active-controlled study was done at 19 sites in the UK and four in Poland. Adult participants who had received a two-dose AZD1222 or mRNA vaccine primary series were randomly assigned by means of an Interactive Response Technology-Randomisation and Trial Supply Management system (1:1 within each primary-series cohort, stratified by age, sex, and comorbidities) to receive AZD1222 or AZD2816 (intramuscular injection; 5 \u00d7 1010 viral particles). Participants, investigators, and all sponsor staff members involved in study conduct were masked to randomisation. AZD1222 and AZD2816 doses were prepared by unmasked study staff members. The primary objectives were to evaluate safety and humoral immunogenicity (non-inferiority of day-29 pseudovirus neutralising antibody geometric mean titre [GMT] against ancestral SARS-CoV-2: AZD1222 booster vs AZD1222 primary series [historical controls]; margin 0\u00b767; SARS-CoV-2-seronegative participants). This study is registered with ClinicalTrials.gov, NCT04973449, and is completed.\r\n\r\nBetween June 27 and Sept 30, 2021, 1394 participants of the 1741 screened were randomly assigned to AZD1222 or AZD2816 following an AZD1222 (n=373, n=377) or mRNA vaccine (n=322, n=322) primary series. In SARS-CoV-2-seronegative participants receiving AZD1222 or AZD2816, 78% and 80% (AZD1222 primary series) and 90% and 93%, respectively (mRNA vaccine primary series) reported solicited adverse events to the end of day 8; 2%, 2%, 1%, and 1% had serious adverse events and 12%, 12%, 10%, and 11% had adverse events of special interest, respectively, to the end of day 180. The primary immunogenicity non-inferiority endpoint was met: day-29 neutralising antibody GMT ratios (ancestral SARS-CoV-2) were 1\u00b702 (95% CI 0\u00b790-1\u00b714) and 3\u00b747 (3\u00b709-3\u00b789) with AZD1222 booster versus historical controls (AZD1222 and mRNA vaccine primary series, respectively). Responses against beta were greater with AZD2816 versus AZD1222 (GMT ratios, AZD1222, mRNA vaccine primary series 1\u00b784 [1\u00b763-2\u00b708], 2\u00b722 [1\u00b799-2\u00b747]).\r\n\r\nBoth boosters were well tolerated, with immunogenicity against ancestral SARS-CoV-2 similar to AZD1222 primary-series vaccination. AZD2816 gave greater immune responses against beta versus AZD1222.\r\n\r\nAstraZeneca.", "doi": "10.1016/S2666-5247(23)00177-5", "pmid": "37783221", "labels": {"Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2666-5247(23)00177-5"}, {"db": "ClinicalTrials.gov", "key": "NCT04973449"}], "notes": [], "created": "2023-11-01T13:32:28.537Z", "modified": "2023-11-02T07:07:24.695Z"}, {"entity": "publication", "iuid": "27e0d5700ad1481da547ca6ce00cc480", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27e0d5700ad1481da547ca6ce00cc480.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27e0d5700ad1481da547ca6ce00cc480"}}, "title": "High-Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure due to COVID-19: A Multicenter Phase 2 Trial.", "authors": [{"family": "Di Fenza", "given": "Raffaele", "initials": "R", "orcid": "0000-0002-5675-7139", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bcbe9c9fe5f847fabd8d6e53c1b2ea60.json"}}, {"family": "Shetty", "given": "Naman S", "initials": "NS"}, {"family": "Gianni", "given": "Stefano", "initials": "S", "orcid": "0000-0002-0838-3654", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8a1132dcdb545a295319cb92c8d1557.json"}}, {"family": "Parcha", "given": "Vibhu", "initials": "V"}, {"family": "Giammatteo", "given": "Valentina", "initials": "V"}, {"family": "Safaee Fakhr", "given": "Bijan", "initials": "B"}, {"family": "Tornberg", "given": "Daniel", "initials": "D"}, {"family": "Wall", "given": "Olof", "initials": "O"}, {"family": "Harbut", "given": "Piotr", "initials": "P"}, {"family": "Lai", "given": "Peggy S", "initials": "PS", "orcid": "0000-0001-9501-8606", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b173a83f2ea442788446cd145854b2c.json"}}, {"family": "Li", "given": "Jonathan Z", "initials": "JZ"}, {"family": "Paganoni", "given": "Sabrina", "initials": "S"}, {"family": "Cenci", "given": "Stefano", "initials": "S"}, {"family": "Mueller", "given": "Ariel L", "initials": "AL"}, {"family": "Houle", "given": "Timothy T", "initials": "TT"}, {"family": "Akeju", "given": "Oluwaseun", "initials": "O"}, {"family": "Bittner", "given": "Edward A", "initials": "EA"}, {"family": "Bose", "given": "Somnath", "initials": "S"}, {"family": "Scott", "given": "Louie K", "initials": "LK"}, {"family": "Carroll", "given": "Ryan W", "initials": "RW", "orcid": "0000-0002-7513-7023", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/394cd170a6fc4f418d6849a6e4c694f8.json"}}, {"family": "Ichinose", "given": "Fumito", "initials": "F"}, {"family": "Hedenstierna", "given": "Magnus", "initials": "M"}, {"family": "Arora", "given": "Pankaj", "initials": "P"}, {"family": "Berra", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-2702-2093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b2fe95c4fbc402884a22f1d83931708.json"}}], "type": "journal article", "published": "2023-09-29", "journal": {"title": "Am J Respir Crit Care Med", "issn": "1535-4970", "issn-l": "1073-449X", "volume": null, "issue": null, "pages": null}, "abstract": "The effects of high-dose inhaled nitric oxide on hypoxemia in COVID-19 acute respiratory failure are unknown.\r\n\r\nMechanically ventilated adults with COVID-19 pneumonia were enrolled in a phase II, multicenter, single-blind, randomized, controlled, parallel-arm trial. Participants in the intervention arm received inhaled nitric oxide at 80 parts-per-million (ppm) for 48h, compared with the control group receiving usual care (without placebo). The primary outcome was the change in arterial oxy-genation (PaO2/FiO2) at 48h. The secondary outcomes included: time to reach a PaO2/FiO2>300 mmHg for at least 24h, the proportion of participants with a PaO2/FiO2>300 mmHg at 28 days, and survival at 28- and 90-days.\r\n\r\n193 participants were included in the modified intention-to-treat analysis. The mean change in PaO2/FiO2 ratio at 48h was 28.3 mmHg in the intervention group and -1.4 mmHg in the control group (mean difference: 39.1 mmHg (95%CrI:18.1-60.3). The mean time to reach a PaO2/FiO2>300 mmHg in the interventional group was 8.7 days com-pared to 8.4 days for the control group (mean difference:0.44(95%CrI:-3.63 to 4.53)). At 28 days, the proportion of participants attaining a PaO2/FiO2>300 mmHg was 27.7% in the inhaled nitric oxide group and 17.2% in the controls (RR:2.03(95%CrI:1.11 to 3.86)). Duration of ventilation and mortality at 28 and 90 days did not differ. No serious adverse events were reported.\r\n\r\nThe use of high-dose inhaled nitric oxide resulted in an improvement of PaO2/FiO2 at 48h compared with usual care in adults with acute hypoxemic respiratory failure due to COVID-19. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/). Clinical trial registration available at www.\r\n\r\ngov, ID: NCT04306393.", "doi": "10.1164/rccm.202304-0637OC", "pmid": "37774011", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT04306393"}], "notes": [], "created": "2023-10-06T06:57:10.441Z", "modified": "2023-10-06T11:38:31.714Z"}, {"entity": "publication", "iuid": "032ae9a98555402d8605ba6cadfbad32", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/032ae9a98555402d8605ba6cadfbad32.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/032ae9a98555402d8605ba6cadfbad32"}}, "title": "Comparative study between virus neutralisation testing and other serological methods detecting anti-SARS-CoV-2 antibodies in Europe, 2021.", "authors": [{"family": "M\u00f6gling", "given": "Ramona", "initials": "R"}, {"family": "Reimerink", "given": "Johan", "initials": "J"}, {"family": "Stanoeva", "given": "Kamelia R", "initials": "KR"}, {"family": "Keramarou", "given": "Maria", "initials": "M"}, {"family": "Guiomar", "given": "Raquel", "initials": "R"}, {"family": "Costa", "given": "In\u00eas", "initials": "I"}, {"family": "Haveri", "given": "Anu", "initials": "A"}, {"family": "Holzer", "given": "Barbara", "initials": "B"}, {"family": "Korukluo\u011flu", "given": "G\u00fclay", "initials": "G"}, {"family": "Nguyen", "given": "Trung", "initials": "T"}, {"family": "Pakarna", "given": "Gatis", "initials": "G"}, {"family": "Pancer", "given": "Katarzyna", "initials": "K"}, {"family": "Trilar", "given": "Katarina Prosenc", "initials": "KP"}, {"family": "Protic", "given": "Jelena", "initials": "J"}, {"family": "Stojanovi\u0107", "given": "Marijana", "initials": "M"}, {"family": "De Santis", "given": "Riccardo", "initials": "R"}, {"family": "Lista", "given": "Florigio", "initials": "F"}, {"family": "Vremera", "given": "Teodora", "initials": "T"}, {"family": "Leustean", "given": "Mihaela", "initials": "M"}, {"family": "Pistol", "given": "Adriana", "initials": "A"}, {"family": "Zelena", "given": "Hana", "initials": "H"}, {"family": "Reusken", "given": "Chantal", "initials": "C"}, {"family": "Broberg", "given": "Eeva K", "initials": "EK"}], "type": "journal article", "published": "2023-09-29", "journal": {"title": "J Virol Methods", "issn": "1879-0984", "issn-l": null, "volume": "322", "issue": null, "pages": "114825"}, "abstract": "One consequence of the ongoing coronavirus disease pandemic was the rapid development of both in-house and commercial serological assays detecting anti-SARS-CoV-2 antibodies, in an effort to reliably detect acute and past SARS-CoV-2 infections. It is crucial to evaluate the quality of these serological tests and consequently the sero-epidemiological studies that are performed with the respective tests. Here, we describe the set-up and results of a comparative study, in which a laboratory contracted by the European Centre for Disease Prevention and Control offered a centralised service to EU/EEA Member and pre-accession Member States to test representative serum specimens with known serological results, with the gold standard technique (virus neutralisation tests) to determine the presence of neutralising antibodies. Laboratories from 12 European countries shared 719 serum specimens with the contractor laboratory. We found that in-house serological tests detecting neutralising antibodies showed the highest percent agreement, both positive and negative, with the virus neutralisation test results. Despite extensive differences in virus neutralisation protocols neutralisation titres showed a strong correlation. From the commercial assays, the best positive percent agreement was found for SARS-CoV-2 IgG (sCOVG) (Siemens - Atellica IM Analyzer). Despite lower positive percent agreement of LIAISON SARS-CoV-2 TrimericS IgG kit (Diasorin Inc.), the obtained results showed relatively good correlation with neutralisation titres. The set-up of this study allowed for high comparability between laboratories and enabled laboratories that do not have the capacity or capability to perform VNTs themselves. Given the variety of in-house protocols detecting SARS-CoV-2 specific neutralising antibodies, including the virus strain, it could be of interest to select reference isolates for SARS-CoV-2 diagnostic to be made available for interested EU Member States and pre-accession countries.", "doi": "10.1016/j.jviromet.2023.114825", "pmid": "37778539", "labels": {"Category: Biochemistry": null, "Category: Serology": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0166-0934(23)00150-7"}], "notes": [], "created": "2023-11-01T13:34:01.625Z", "modified": "2023-11-02T07:39:20.575Z"}, {"entity": "publication", "iuid": "36ec5251e59b4ffbb0ba152f3d9aecb7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/36ec5251e59b4ffbb0ba152f3d9aecb7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/36ec5251e59b4ffbb0ba152f3d9aecb7"}}, "title": "Changes in stroke and TIA admissions during the COVID-19 pandemic: A meta-analysis.", "authors": [{"family": "Gunnarsson", "given": "Karin", "initials": "K"}, {"family": "Tofiq", "given": "Avin", "initials": "A", "orcid": "0000-0003-1712-7510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1460dc1501cf4a599430688991f6139f.json"}}, {"family": "Mathew", "given": "Alen", "initials": "A"}, {"family": "Cao", "given": "Yang", "initials": "Y", "orcid": "0000-0002-3552-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7594ca0fdf2d4f238ca04a788a405cdb.json"}}, {"family": "von Euler", "given": "Mia", "initials": "M"}, {"family": "Str\u00f6m", "given": "Jakob O", "initials": "JO"}], "type": "journal article", "published": "2023-09-29", "journal": {"title": "Eur Stroke J", "issn": "2396-9881", "issn-l": null, "volume": null, "issue": null, "pages": "23969873231204127"}, "abstract": "To perform a meta-analysis on how the admissions of stroke and transient ischemic attack (TIA) changed during the Corona Virus infection-19 (COVID-19) pandemic and evaluate if the effect was depending on stroke severity.\r\n\r\nObservational cohort studies comparing the number of stroke and/or TIA admissions during a period of the pandemic compared to a period before the pandemic were identified in PubMed and Embase. After excluding studies with overlapping populations and studies without satisfactory case ascertainment, data was extracted and meta-analyzed.\r\n\r\nA total of 59 studies were included. During the pandemic, there was a decrease in admissions of ischemic stroke (admission rate ratio (ARR) = 0.77, 95% confidence interval (CI): 0.72, 0.82), intracerebral hemorrhage (ARR = 0.79, 95% CI: 0.70, 0.90) and TIA (ARR = 0.66, 95% CI: 0.58, 0.75). Albeit admission rates of both mild (ARR = 0.61, 95% CI: 0.49, 0.77) and severe (ARR = 0.82, 95% CI = 0.71, 0.95) strokes decreased, milder strokes decreased more (proportion ratio (PR) = 0.76, 95% CI: 0.65, 0.89).\r\n\r\nPotential causes for the admission reduction could be strict prioritizations within the health care, patients' fear of acquiring COVID-19, or decreased access to health care due to lockdowns.\r\n\r\nDuring the COVID-19 pandemic, there was a reduction in admissions of stroke and TIA, possibly caused by reluctance to seek medical care.", "doi": "10.1177/23969873231204127", "pmid": "37776062", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:32:25.891Z", "modified": "2023-11-02T07:06:00.857Z"}, {"entity": "publication", "iuid": "89f03addb5ce4c9e9e0d934e562cefec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/89f03addb5ce4c9e9e0d934e562cefec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/89f03addb5ce4c9e9e0d934e562cefec"}}, "title": "The Impact of the COVID-19 Pandemic on the Psychological Well-Being of Caregivers of People with Dementia or Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.", "authors": [{"family": "Soysal", "given": "Pinar", "initials": "P", "orcid": "0000-0002-6042-1718", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9532f14058b74f4ba9ef9a91363ef928.json"}}, {"family": "Veronese", "given": "Nicola", "initials": "N", "orcid": "0000-0002-9328-289X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a2cc37554334aa09c617b388c653fd6.json"}}, {"family": "Smith", "given": "Lee", "initials": "L", "orcid": "0000-0002-5340-9833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4a80139dc424c4a83615832dfdff7fc.json"}}, {"family": "Chen", "given": "Yaohua", "initials": "Y", "orcid": "0000-0003-1778-1790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b457f904786486499affe9db4fd9610.json"}}, {"family": "Akpinar Soylemez", "given": "Burcu", "initials": "B"}, {"family": "Coin", "given": "Alessandra", "initials": "A"}, {"family": "Religa", "given": "Dorota", "initials": "D", "orcid": "0000-0003-4583-4570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e2c968ecffa4c638126d6d8d4a0dbd9.json"}}, {"family": "V\u00e4lim\u00e4ki", "given": "Tarja", "initials": "T", "orcid": "0000-0001-6178-5671", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1d17a5f5f124cf1b87188ef357e78a9.json"}}, {"family": "Alves", "given": "Mariana", "initials": "M"}, {"family": "Shenkin", "given": "Susan D", "initials": "SD", "orcid": "0000-0001-7375-4776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/939e65f9dcda409796466872995bdbd1.json"}}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "Geriatrics (Basel)", "issn": "2308-3417", "issn-l": null, "volume": "8", "issue": "5", "pages": null}, "abstract": "The aim of this systematic review was to investigate the effects of the COVID-19 lockdown on the psychological well-being of caregivers of people with dementia or mild cognitive impairment (PwD/MCI). Electronic databases were searched from inception to August 2022 for observational studies investigating the COVID-19 lockdown and psychological well-being of caregivers of PwD/MCI. Summary estimates of standardized mean differences (SMD) in psychological well-being scores pre- versus during COVID-19 were calculated using a random-effects model. Fifteen studies including 1702 caregivers (65.7% female, mean age 60.40 \u00b1 12.9 years) with PwD/MCI were evaluated. Five studies found no change in psychological well-being parameters, including depression, anxiety, distress, caregiver burden, and quality of life. Ten studies found a worsening in at least one parameter: depression (six studies, n = 1368; SMD = 0.40; 95%CI: 0.09-0.71; p = 0.01, I2 = 86.8%), anxiety (seven studies, n = 1569; SMD = 1.35; 95%CI: 0.05-2.65; I2 = 99.2%), caregiver distress (six studies, n = 1320, SMD = 3.190; 95%CI: 1.42-4.95; p < 0.0001; I2 = 99.4%), and caregiver burden (four studies, n = 852, SMD = 0.34; 95%CI: 0.13-0.56; p = 0.001; I2 = 54.1%) (p < 0.05). There was an increase in depression, anxiety, caregiver burden, and distress in caregivers of PwD/MCI during the lockdown in the COVID pandemic. This could have longer term consequences, and it is essential that caregivers' psychological well-being is assessed and supported, to benefit both themselves and those for whom they care.", "doi": "10.3390/geriatrics8050097", "pmid": "37887970", "labels": {"Type: Review": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10606547"}, {"db": "pii", "key": "geriatrics8050097"}], "notes": [], "created": "2023-11-02T07:26:36.865Z", "modified": "2023-11-02T07:27:19.520Z"}, {"entity": "publication", "iuid": "2102e5f0fcb94665b9e6809fb4fb6148", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2102e5f0fcb94665b9e6809fb4fb6148.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2102e5f0fcb94665b9e6809fb4fb6148"}}, "title": "Reproducibility in pharmacometrics applied in a phase III trial of BCG-vaccination for COVID-19.", "authors": [{"family": "van Wijk", "given": "Rob C", "initials": "RC", "orcid": "0000-0001-7247-1360", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aac8bd1a2d674d6c891c1a0becf997d8.json"}}, {"family": "Mockeliunas", "given": "Laurynas", "initials": "L"}, {"family": "van den Hoogen", "given": "Gerben", "initials": "G"}, {"family": "Upton", "given": "Caryn M", "initials": "CM", "orcid": "0000-0002-7503-3320", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/518562f81f0340acaeb7f202bb01403a.json"}}, {"family": "Diacon", "given": "Andreas H", "initials": "AH"}, {"family": "Simonsson", "given": "Ulrika S H", "initials": "USH", "orcid": "0000-0002-3424-9686", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf510f552f2846b5bbb7740872a7c24a.json"}}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "16292"}, "abstract": "Large clinical trials often generate complex and large datasets which need to be presented frequently throughout the trial for interim analysis or to inform a data safety monitory board (DSMB). In addition, reliable and traceability are required to ensure reproducibility in pharmacometric data analysis. A reproducible pharmacometric analysis workflow was developed during a large clinical trial involving 1000 participants over one year testing Bacillus Calmette-Gu\u00e9rin (BCG) (re)vaccination in coronavirus disease 2019 (COVID-19) morbidity and mortality in frontline health care workers. The workflow was designed to review data iteratively during the trial, compile frequent reports to the DSMB, and prepare for rapid pharmacometric analysis. Clinical trial datasets (n = 41) were transferred iteratively throughout the trial for review. An RMarkdown based pharmacometric processing script was written to automatically generate reports for evaluation by the DSMB. Reports were compiled, reviewed, and sent to the DSMB on average three days after the data cut-off, reflecting the trial progress in real-time. The script was also utilized to prepare for the trial pharmacometric analyses. The same source data was used to create analysis datasets in NONMEM format and to support model script development. The primary endpoint analysis was completed three days after data lock and unblinding, and the secondary endpoint analyses two weeks later. The constructive collaboration between clinical, data management, and pharmacometric teams enabled this efficient, timely, and reproducible pharmacometrics workflow.", "doi": "10.1038/s41598-023-43412-3", "pmid": "37770596", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10539503"}, {"db": "pii", "key": "10.1038/s41598-023-43412-3"}], "notes": [], "created": "2023-10-06T06:57:15.951Z", "modified": "2023-10-06T11:40:12.550Z"}, {"entity": "publication", "iuid": "17149842d47b4a09bb7a58f9d9341fb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/17149842d47b4a09bb7a58f9d9341fb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/17149842d47b4a09bb7a58f9d9341fb1"}}, "title": "Neurofilament light chain on intensive care admission is an independent predictor of mortality in COVID-19: a prospective multicenter study.", "authors": [{"family": "Sievert", "given": "Theodor", "initials": "T", "orcid": "0009-0009-9630-2540", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a8d175437a84f5c863058f2207ca332.json"}}, {"family": "Didriksson", "given": "Ingrid", "initials": "I"}, {"family": "Sp\u00e5ngfors", "given": "Martin", "initials": "M"}, {"family": "Lilja", "given": "Gisela", "initials": "G"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Frigyesi", "given": "Attila", "initials": "A"}, {"family": "Friberg", "given": "Hans", "initials": "H"}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "Intensive Care Med Exp", "issn": "2197-425X", "issn-l": null, "volume": "11", "issue": "1", "pages": "66"}, "abstract": "Neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and total-tau protein (tau) are novel blood biomarkers of neurological injury, and may be used to predict outcomes in critical COVID-19.\r\n\r\nA prospective multicentre cohort study of 117 consecutive and critically ill COVID-19 patients in six intensive care units (ICUs) in southern Sweden between May and November 2020. Serial NfL, GFAP and tau were analysed in relation to mortality, the Glasgow Outcome Scale Extended (GOSE) and the physical (PCS) and mental (MCS) components of health-related quality of life at one year.\r\n\r\nNfL, GFAP and tau on ICU admission predicted one-year mortality with an area under the curve (AUC) of 0.82 (95% confidence interval [CI] 0.74[Formula: see text]0.90), 0.72 (95% CI 0.62[Formula: see text]0.82) and 0.66 (95% CI 0.54[Formula: see text]0.77). NfL on admission was an independent predictor of one-year mortality (p = 0.039). Low NfL and GFAP values were associated with good PCS ([Formula: see text]45) at one year but not with good MCS ([Formula: see text]45) or GOSE ([Formula: see text]5).\r\n\r\nNfL on ICU admission was an independent predictor of mortality. High levels of NfL, GFAP and tau were associated with mortality but not with poor GOSE in survivors at one year. Low levels of NfL and GFAP were associated with improved physical health-related quality of life.", "doi": "10.1186/s40635-023-00547-x", "pmid": "37768470", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null, "Category: Public Health": null, "Funder: H2020": null}, "xrefs": [{"db": "pmc", "key": "PMC10539241"}, {"db": "pii", "key": "10.1186/s40635-023-00547-x"}], "notes": [], "created": "2023-10-06T06:56:44.290Z", "modified": "2023-10-06T11:27:36.202Z"}, {"entity": "publication", "iuid": "49150db4defd486aae6259e7cdee919d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49150db4defd486aae6259e7cdee919d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49150db4defd486aae6259e7cdee919d"}}, "title": "Increased intra-pulmonary shunt and alveolar dead space post COVID-19.", "authors": [{"family": "Farrow", "given": "Catherine E", "initials": "CE"}, {"family": "Robles", "given": "Robert", "initials": "R"}, {"family": "Prisk", "given": "G Kim", "initials": "GK"}, {"family": "Harbut", "given": "Piotr", "initials": "P"}, {"family": "Malhotra", "given": "Atul", "initials": "A"}, {"family": "Amis", "given": "Terence C", "initials": "TC"}, {"family": "Wagner", "given": "Peter D", "initials": "PD"}, {"family": "Kairaitis", "given": "Kristina", "initials": "K"}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "J Appl Physiol (1985)", "issn": "1522-1601", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Increased intrapulmonary shunt(QS/Qt) and alveolar dead space(VD/VT) are present in early recovery from COVID-19. We hypothesized patients recovering from severe-critical acute illness(NIH category 3-5) would have greater and longer-lasting increased QS/Qt and VD/VT than patients with mild-moderate acute illness(NIH 1-2).\r\n\r\n59 unvaccinated patients (33 male, age 52[38-61] years, BMI 28.8[25.3-33.6] kg/m2; median[IQR], 44 previous mild-moderate COVID-19, and 15 severe-critical disease), were studied 15-403 days post-acute SARS-CoV-2 infection. Breathing ambient air, steady-state mean alveolar PCO2 and PO2 were recorded simultaneously with arterial PO2/PCO2 yielding aAPCO2, AaPO2, and from these, QS/Qt%, VD/VT%, and relative alveolar ventilation (40 mmHg/PACO2, VArel) calculated.\r\n\r\nMedian PaCO2 was 39.4[35.6-41.1] mmHg, PaO2 92.3[87.1-98.2mmHg; PACO2 32.8[28.6-35.3] mmHg, PAO2 112.9[109.4-117.0] mmHg, AaPO2 18.8[12.6-26.8] mmHg, aAPCO2 5.9 [4.3-8.0] mmHg, QS/Qt 4.3 [2.1-5.9] % and VD/VT16.6 [12.6-24.4] %. Only 14% of patients had normal QS/Qt and VD/VT;1% increased QS/Qt but normal VD/VT; 49% normal QS/Qt and elevated VD/VT;36% both abnormal QS/Qtand VD/VT. Previous severe-critical COVID-19 predicted increased QS/Qt (2.69 [0.82-4.57]% per category severity [95% CI], p<0.01), but not VD/VT. Increasing age weakly predicted increased VD/VT (1.6 [0.1-3.2]% per decade, p<0.04). Time since infection, BMI and comorbidities were not predictors (all p > 0.11). VArel was increased in most patients.\r\n\r\nIn our population, recovery from COVID-19 was associated with increased QS/Qt in 37% of patients, increased VD/VT in 86%, and increased alveolar ventilation up to ~13 months post infection. NIH severity predicted QS/Qt but not elevated VD/VT. Increased VD/VT suggests pulmonary micro-vascular pathology persists post COVID-19 in most patients.", "doi": "10.1152/japplphysiol.00267.2023", "pmid": "37767555", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:56:06.924Z", "modified": "2023-10-06T11:05:04.600Z"}, {"entity": "publication", "iuid": "8a71d2ffb92044e7b93c1c9be9dd275c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a71d2ffb92044e7b93c1c9be9dd275c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a71d2ffb92044e7b93c1c9be9dd275c"}}, "title": "Impact of COVID-19 in Patients with Heart Failure with Mildly Reduced or Preserved Ejection Fraction Enrolled in the DELIVER Trial.", "authors": [{"family": "Bhatt", "given": "Ankeet S", "initials": "AS"}, {"family": "Kosiborod", "given": "Mikhail N", "initials": "MN"}, {"family": "Claggett", "given": "Brian L", "initials": "BL"}, {"family": "Miao", "given": "Zi Michael", "initials": "ZM"}, {"family": "Vaduganathan", "given": "Muthiah", "initials": "M"}, {"family": "Lam", "given": "Carolyn S P", "initials": "CSP"}, {"family": "Hernandez", "given": "Adrian F", "initials": "AF"}, {"family": "Martinez", "given": "Felipe A", "initials": "FA"}, {"family": "Inzucchi", "given": "Silvio E", "initials": "SE"}, {"family": "Shah", "given": "Sanjiv J", "initials": "SJ"}, {"family": "de Boer", "given": "Rudolf A", "initials": "RA"}, {"family": "Jhund", "given": "Pardeep S", "initials": "PS"}, {"family": "Desai", "given": "Akshay S", "initials": "AS"}, {"family": "Fang", "given": "James C", "initials": "JC"}, {"family": "Han", "given": "Yaling", "initials": "Y"}, {"family": "Comin-Colet", "given": "Josep", "initials": "J"}, {"family": "Dro\u017cd\u017c", "given": "Jaros\u0142aw", "initials": "J"}, {"family": "Vardeny", "given": "Orly", "initials": "O"}, {"family": "Merkely", "given": "Bela", "initials": "B"}, {"family": "Lindholm", "given": "Daniel", "initials": "D"}, {"family": "Peterson", "given": "Magnus", "initials": "M"}, {"family": "Langkilde", "given": "Anna Maria", "initials": "AM"}, {"family": "McMurray", "given": "John J V", "initials": "JJV"}, {"family": "Solomon", "given": "Scott D", "initials": "SD"}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "Eur J Heart Fail", "issn": "1879-0844", "issn-l": "1388-9842", "volume": null, "issue": null, "pages": null}, "abstract": "COVID-19 may affect clinical risk in patients with heart failure. DELIVER began before and was conducted during the COVID-19 pandemic.\r\n\r\nWe evaluated the association between COVID-19 and outcomes among DELIVER participants.\r\n\r\nParticipants with chronic HFmrEF/HFpEF were randomized to dapagliflozin or placebo across 350 sites in 20 countries. COVID-19 was investigator-reported and the contribution of COVID-19 to death was centrally adjudicated. We assessed (1) incidence of COVID-19, (2) event rates before/during the pandemic, and (3) risks of death after diagnosis compared to death in participants without COVID-19. Further, we performed a sensitivity analysis assessing treatment effects censored at pandemic onset.\r\n\r\nOf 6263 participants, 589 (9.4%) developed COVID-19, of whom 307 (52%) required/prolonged hospitalization. 155 deaths (15% of all deaths) were adjudicated as definitely/possibly COVID-19 related. COVID-19 cases and deaths did not differ by randomized assignment. Death-rate in the 12-months following diagnosis was 56.1 (95% CI:48.0 to 65.6) vs. 6.4 (95% CI:6.0-6.8)/100-participant-years among trial participants with versus without COVID-19 (aHR:8.60,95% CI:7.18-10.30). Risk was highest 0-3 months following diagnosis (153.5,95% CI:130.3-180.8) and remained elevated at 3-6 months (12.6,95% CI:6.6-24.3/100-participant-years). After excluding investigator reported fatal COVID-19 events, all-cause death rates in the 12 months following diagnosis among COVID-19 survivors (n = 458) remained higher (aHR: 2.46, 95% CI: 1.83 to 3.33) than all trial participants from randomization, with censoring of participants who developed COVID-19 at the time of diagnosis. Dapagliflozin reduced the CV death/worsening HF events when censoring participants at COVID-19 diagnosis (HR:0.81,95%CI:0.72-0.91) and pandemic onset (HR:0.72,95%CI:0.58-0.89). There were no DKA or major hypoglycemic events within 30-days of COVID-19.\r\n\r\nDELIVER is one of the most extensive experiences with COVID-19 of any cardiovascular trial, with >75% of follow-up time occurring during the pandemic. COVID-19 was common, with >50% of cases leading to hospitalization or death. Treatment benefits of dapagliflozin persisted when censoring at COVID-19 diagnosis and pandemic onset. Patients surviving COVID-19 event had a high early residual risk. This article is protected by copyright. All rights reserved.", "doi": "10.1002/ejhf.3043", "pmid": "37771274", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:55:17.131Z", "modified": "2023-10-06T10:49:36.886Z"}, {"entity": "publication", "iuid": "ffccce5c119444b6a27350ba05693be3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ffccce5c119444b6a27350ba05693be3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ffccce5c119444b6a27350ba05693be3"}}, "title": "Gender differences in patient experience in idiopathic inflammatory myopathies: Sub analysis from the COVAD dataset.", "authors": [{"family": "Yoshida", "given": "Akira", "initials": "A", "orcid": "0000-0003-3590-1637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e26dfbeb7e8486a8492abc2700590df.json"}}, {"family": "Kim", "given": "Minchul", "initials": "M"}, {"family": "Kuwana", "given": "Masataka", "initials": "M"}, {"family": "Ravichandran", "given": "Naveen", "initials": "N"}, {"family": "Makol", "given": "Ashima", "initials": "A"}, {"family": "Sen", "given": "Parikshit", "initials": "P"}, {"family": "Lilleker", "given": "James B", "initials": "JB"}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V"}, {"family": "Kardes", "given": "Sinan", "initials": "S"}, {"family": "Day", "given": "Jessica", "initials": "J"}, {"family": "Milchert", "given": "Marcin", "initials": "M"}, {"family": "Joshi", "given": "Mrudula", "initials": "M"}, {"family": "Gheita", "given": "Tamer", "initials": "T"}, {"family": "Salim", "given": "Babur", "initials": "B"}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T"}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE"}, {"family": "Parodis", "given": "Ioannis", "initials": "I"}, {"family": "Nikiphorou", "given": "Elena", "initials": "E"}, {"family": "Chatterjee", "given": "Tulika", "initials": "T"}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL"}, {"family": "Nune", "given": "Arvind", "initials": "A"}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L"}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA"}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK"}, {"family": "Ziade", "given": "Nelly", "initials": "N"}, {"family": "Knitza", "given": "Johannes", "initials": "J"}, {"family": "Distler", "given": "Oliver", "initials": "O"}, {"family": "Chinoy", "given": "Hector", "initials": "H"}, {"family": "Agarwal", "given": "Vikas", "initials": "V"}, {"family": "Aggarwal", "given": "Rohit", "initials": "R"}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "Mod Rheumatol", "issn": "1439-7609", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "We aimed to investigate gender-based differences in idiopathic inflammatory myopathies (IIMs), with a particular focus on patient-reported outcomes, utilizing data obtained through the international COVID-19 vaccination in autoimmune disease (COVAD) e-survey.\r\n\r\nPatient-reported outcomes including fatigue, pain, and physical function were extracted from the COVAD database and compared between genders, adjusting for demographics and IIM subgroups by multivariable analysis. Inclusion body myositis (IBM) was analysed separately because of substantial differences in outcomes.\r\n\r\n1197 complete responses from patients with IIMs as of 31 August 2021 were analysed. Seventy percent were women. Women were younger (58 [48-68] vs. 69 [58-75] years old, median [IQR], p < 0.001) and more likely to suffer from autoimmune multimorbidity, defined as three or more autoimmune diseases in an individual patient (11.4% vs. 2.8%, p < 0.001). In non-IBM IIMs, fatigue visual analogue scale scores were higher in women (5 [3-7] vs. 4 [2-6], median [IQR], p = 0.004), whereas no significant gender-based differences were noted in IBM. Multivariable analysis in non-IBM IIMs revealed women, residence in high-income countries, overlap myositis, and autoimmune multimorbidity were independently associated with increased fatigue.\r\n\r\nWomen with IIMs suffer from autoimmune multimorbidity and experience increased fatigue compared to men.", "doi": "10.1093/mr/road094", "pmid": "37769200", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "7285588"}], "notes": [], "created": "2023-10-06T06:57:42.055Z", "modified": "2023-10-06T11:47:26.839Z"}, {"entity": "publication", "iuid": "16e8a5f9090f4d7c933c8cfd4386eda0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16e8a5f9090f4d7c933c8cfd4386eda0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16e8a5f9090f4d7c933c8cfd4386eda0"}}, "title": "Evaluation of a human mucosal tissue explant model for SARS-CoV-2 replication.", "authors": [{"family": "Gordhan", "given": "Bhavna Gowan", "initials": "BG"}, {"family": "Herrera", "given": "Carolina", "initials": "C"}, {"family": "Pillay", "given": "Azure-Dee", "initials": "A"}, {"family": "Seiphetlo", "given": "Thabiso", "initials": "T"}, {"family": "Ealand", "given": "Christopher Shawn", "initials": "CS"}, {"family": "Machowski", "given": "Edith", "initials": "E"}, {"family": "Singh", "given": "Natasha", "initials": "N"}, {"family": "Seatholo", "given": "Ntombexolo", "initials": "N"}, {"family": "Otwombe", "given": "Kennedy", "initials": "K"}, {"family": "Lebina", "given": "Limakatso", "initials": "L"}, {"family": "Frise", "given": "Rebecca", "initials": "R"}, {"family": "Scarlatti", "given": "Gabriella", "initials": "G"}, {"family": "Chiodi", "given": "Francesca", "initials": "F"}, {"family": "Martinson", "given": "Neil", "initials": "N"}, {"family": "Fox", "given": "Julie", "initials": "J"}, {"family": "Kana", "given": "Bavesh Davandra", "initials": "BD", "orcid": "0000-0001-9713-3480", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/444ca8b6b7e444f1a55ddab2e87c5f2d.json"}}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "9", "pages": "e0291146"}, "abstract": "With the onset of COVID-19, the development of ex vivo laboratory models became an urgent priority to study host-pathogen interactions in response to the pandemic. In this study, we aimed to establish an ex vivo mucosal tissue explant challenge model for studying SARS-CoV-2 infection and replication. Nasal or oral tissue samples were collected from eligible participants and explants generated from the tissue were infected with various SARS-CoV-2 strains, including IC19 (lineage B.1.13), Beta (lineage B.1.351) and Delta (lineage B.1.617.2). A qRT-PCR assay used to measure viral replication in the tissue explants over a 15-day period, demonstrated no replication for any viral strains tested. Based on this, the ex vivo challenge protocol was modified by reducing the viral infection time and duration of sampling. Despite these changes, viral infectivity of the nasal and oral mucosa was not improved. Since 67% of the enrolled participants were already vaccinated against SARS-CoV-2, it is possible that neutralizing antibodies in explant tissue may have prevented the establishment of infection. However, we were unable to optimize plaque assays aimed at titrating the virus in supernatants from both infected and uninfected tissue, due to limited volume of culture supernatant available at the various collection time points. Currently, the reasons for the inability of these mucosal tissue samples to support replication of SARS-CoV-2 ex vivo remains unclear and requires further investigation.", "doi": "10.1371/journal.pone.0291146", "pmid": "37769001", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Other": null, "Category: Genomics & transcriptomics": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC10538748"}, {"db": "pii", "key": "PONE-D-23-15626"}], "notes": [], "created": "2023-10-06T06:52:46.172Z", "modified": "2023-10-06T12:03:46.988Z"}, {"entity": "publication", "iuid": "beb69223dbf744a6a67c81eddf7d1f94", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/beb69223dbf744a6a67c81eddf7d1f94.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/beb69223dbf744a6a67c81eddf7d1f94"}}, "title": "Endotheliitis and cytokine storm as a mechanism of clot formation in COVID-19 ischemic stroke patients: A histopathologic study of retrieved clots.", "authors": [{"family": "Brinjikji", "given": "Waleed", "initials": "W"}, {"family": "Kallmes", "given": "David F", "initials": "DF", "orcid": "0000-0002-8495-0040", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3afdb017a42249bfb13d88ef55c0b77c.json"}}, {"family": "Virmani", "given": "Renu", "initials": "R"}, {"family": "de Meyer", "given": "Simon F", "initials": "SF"}, {"family": "Yoo", "given": "Albert J", "initials": "AJ"}, {"family": "Humphries", "given": "William", "initials": "W"}, {"family": "Zaidat", "given": "Osama O", "initials": "OO"}, {"family": "Teleb", "given": "Mohamed S", "initials": "MS"}, {"family": "Jones", "given": "Jesse G", "initials": "JG", "orcid": "0000-0002-2682-9736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8b2eb443d9242339db2c60ff1e2ff61.json"}}, {"family": "Siddiqui", "given": "Adnan H", "initials": "AH"}, {"family": "Andersson", "given": "Tommy", "initials": "T"}, {"family": "Nogueira", "given": "Raul G", "initials": "RG"}, {"family": "Gil", "given": "Sara Molina", "initials": "SM"}, {"family": "Douglas", "given": "Andrew", "initials": "A"}, {"family": "Rossi", "given": "Rosanna", "initials": "R", "orcid": "0000-0002-3656-2908", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e94c727f4e504aec82996f36a18c4800.json"}}, {"family": "Rentzos", "given": "Alexander", "initials": "A"}, {"family": "Ceder", "given": "Erik", "initials": "E"}, {"family": "Carlqvist", "given": "Jeanette", "initials": "J"}, {"family": "Dunker", "given": "Dennis", "initials": "D"}, {"family": "Jood", "given": "Katarina", "initials": "K"}, {"family": "Tatlisumak", "given": "Turgut", "initials": "T"}, {"family": "Doyle", "given": "Karen M", "initials": "KM", "orcid": "0000-0001-8984-6296", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a3c861faf81495a97e1e85ea3f8dd88.json"}}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "Interv Neuroradiol", "issn": "2385-2011", "issn-l": null, "volume": null, "issue": null, "pages": "15910199231185804"}, "abstract": "Studies during the COVID-19 pandemic have demonstrated an association between COVID-19 virus infection and the development of acute ischemic stroke, particularly large vessel occlusion (LVO). Studying the characteristics and immunohistochemistry of retrieved stroke emboli during mechanical thrombectomy for LVO may offer insights into the pathogenesis of LVO in COVID-19 patients. We examined retrieved COVID-19 emboli from the STRIP, EXCELLENT, and RESTORE registries and compared their characteristics to a control group.\r\n\r\nWe identified COVID-positive LVO patients from the STRIP, RESTORE, and EXCELLENT studies who underwent mechanical thrombectomy. These patients were matched to a control group controlling for stroke etiology based on Trial of Org 10172 in Acute Stroke Treatment criteria. All clots were stained with Martius Scarlet Blue (MSB) along with immunohistochemistry for interleukin-6 (IL-6), C-reactive protein (CRP), von Willebrand factor (vWF), CD66b, fibrinogen, and citrullinated Histone H3. Clot composition was compared between groups.\r\n\r\nNineteen COVID-19-positive patients and 38 controls were included. COVID-19-positive patients had a significantly higher percentage of CRP and vWF. There was no difference in IL-6, fibrin, CD66b, or citrullinated Histone H3 between groups. Based on MSB staining, there was no statistically significant difference regarding the percentage of red blood cells, white blood cells, fibrin, and platelets.\r\n\r\nOur study found higher concentrations of CRP and vWF in retrieved clots of COVID-19-positive stroke patients compared to COVID-19-negative controls. These findings support the potential role of systemic inflammation as indicated by elevated CRP and endothelial injury as indicated by elevated vWF as precipitating factors in thrombus development in these patients.", "doi": "10.1177/15910199231185804", "pmid": "37769315", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:55:14.627Z", "modified": "2023-10-06T10:48:05.804Z"}, {"entity": "publication", "iuid": "d5d748c6457d43149e8ec2a7fe6063af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5d748c6457d43149e8ec2a7fe6063af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5d748c6457d43149e8ec2a7fe6063af"}}, "title": "Prior physical illness predicts death better than acute physiological derangement on intensive care unit admission in COVID-19: A Swedish registry study.", "authors": [{"family": "Stattin", "given": "Karl", "initials": "K", "orcid": "0000-0003-1537-6740", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/249d788a7d1f4088aca67f8265561b9b.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Kawati", "given": "Rafael", "initials": "R"}], "type": "journal article", "published": "2023-09-27", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "9", "pages": "e0292186"}, "abstract": "COVID-19 is associated with prolonged intensive care unit (ICU) stay and considerable mortality. The onset of persistent critical illness, defined as when prior illness predicts death better than acute physiological derangement, has not been studied in COVID-19. This national cohort study based on the Swedish Intensive Care Registry (SIR) included all patients admitted to a Swedish ICU due to COVID-19 from 6 March 2020 to 9 November 2021. Simplified Acute Physiology Score-3 (SAPS3) Box 1 was used as a measure of prior illness and Box 3 as a measure of acute derangement to evaluate the onset and importance of persistent critical illness in COVID-19. To compare predictive capacity, the area under receiver operating characteristic (AUC) of SAPS3 and its constituent Box 1 and 3 was calculated for 30-day mortality. In 7 969 patients, of which 1 878 (23.6%) died within 30 days of ICU admission, the complete SAPS3 score had acceptable discrimination: AUC 0.75 (95% CI 0.74 to 0.76) but showed under prediction in low-risk patients and over prediction in high-risk patients. SAPS3 Box 1 showed markedly better discrimination than Box 3 (AUC 0.74 vs 0.65, P<0,0001). Using custom logistic models, the difference in predictive performance of prior and acute illness was validated, AUC 0.76 vs AUC 0.69, p<0.0001. Prior physical illness predicts death in COVID-19 better than acute physiological derangement during ICU stay, and the whole SAPS3 score is not significantly better than just prior illness. The results suggests that COVID-19 may exhibit similarities to persistent critical illness immediately from ICU admission, potentially because of long median ICU length-of-stay. Alternatively, the variables in the acute physiological derangement model may not adequately capture the severity of illness in COVID-19.", "doi": "10.1371/journal.pone.0292186", "pmid": "37756328", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Public Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: KAW/SciLifeLab": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC10529545"}, {"db": "pii", "key": "PONE-D-23-04974"}], "notes": [], "created": "2023-10-06T06:52:56.012Z", "modified": "2023-10-06T09:59:42.196Z"}, {"entity": "publication", "iuid": "6c3a64fd6fff4dcaa6aa9206c19e2fba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c3a64fd6fff4dcaa6aa9206c19e2fba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c3a64fd6fff4dcaa6aa9206c19e2fba"}}, "title": "Prevalence of SARS-CoV-2 Omicron Sublineages and Spike Protein Mutations Conferring Resistance against Monoclonal Antibodies in a Swedish Cohort during 2022-2023.", "authors": [{"family": "Haars", "given": "Jonathan", "initials": "J", "orcid": "0009-0003-8735-4097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ac6ff5ce97541b9823d1c9204366e56.json"}}, {"family": "Palanisamy", "given": "Navaneethan", "initials": "N", "orcid": "0000-0003-0369-2316", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e92f0f2edcb4c8eaa66f55c59490717.json"}}, {"family": "Wallin", "given": "Frans", "initials": "F"}, {"family": "M\u00f6lling", "given": "Paula", "initials": "P"}, {"family": "Lindh", "given": "Johan", "initials": "J"}, {"family": "Sundqvist", "given": "Martin", "initials": "M"}, {"family": "Ellstr\u00f6m", "given": "Patrik", "initials": "P"}, {"family": "Kaden", "given": "Ren\u00e9", "initials": "R", "orcid": "0000-0002-2111-9751", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2be6374ef0bf4ba39e5f5dbbb059747f.json"}}, {"family": "Lennerstrand", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2023-09-27", "journal": {"title": "Microorganisms", "issn": "2076-2607", "issn-l": "2076-2607", "volume": "11", "issue": "10", "pages": null}, "abstract": "Monoclonal antibodies (mAbs) are an important treatment option for COVID-19 caused by SARS-CoV-2, especially in immunosuppressed patients. However, this treatment option can become ineffective due to mutations in the SARS-CoV-2 genome, mainly in the receptor binding domain (RBD) of the spike (S) protein. In the present study, 7950 SARS-CoV-2 positive samples from the Uppsala and \u00d6rebro regions of central Sweden, collected between March 2022 and May 2023, were whole-genome sequenced using amplicon-based sequencing methods on Oxford Nanopore GridION, Illumina MiSeq, Illumina HiSeq, or MGI DNBSEQ-G400 instruments. Pango lineages were determined and all single nucleotide polymorphism (SNP) mutations that occurred in these samples were identified. We found that the dominant sublineages changed over time, and mutations conferring resistance to currently available mAbs became common. Notable ones are R346T and K444T mutations in the RBD that confer significant resistance against tixagevimab and cilgavimab mAbs. Further, mutations conferring a high-fold resistance to bebtelovimab, such as the K444T and V445P mutations, were also observed in the samples. This study highlights that resistance mutations have over time rendered currently available mAbs ineffective against SARS-CoV-2 in most patients. Therefore, there is a need for continued surveillance of resistance mutations and the development of new mAbs that target more conserved regions of the RBD.", "doi": "10.3390/microorganisms11102417", "pmid": "37894075", "labels": {"Category: Proteins": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10609123"}, {"db": "pii", "key": "microorganisms11102417"}], "notes": [], "created": "2023-11-01T13:31:56.850Z", "modified": "2023-11-01T13:51:18.963Z"}, {"entity": "publication", "iuid": "53b88ea1a9294cf6940e0dc6bb00c61f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53b88ea1a9294cf6940e0dc6bb00c61f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53b88ea1a9294cf6940e0dc6bb00c61f"}}, "title": "Health Care Personnel's Perspectives on Quality of Palliative Care During the COVID-19 Pandemic - A Cross-Sectional Study.", "authors": [{"family": "Granrud", "given": "Marie Dahlen", "initials": "MD"}, {"family": "Gr\u00f8ndahl", "given": "Vigdis Abrahamsen", "initials": "VA", "orcid": "0000-0002-8296-7682", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c34c6c8599e4466af1a3830060dd660.json"}}, {"family": "Helgesen", "given": "Ann Karin", "initials": "AK", "orcid": "0000-0003-4572-9439", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/673ff54d4a6347dfa0b8bb21481e5a8c.json"}}, {"family": "B\u00e5\u00e5th", "given": "Carina", "initials": "C", "orcid": "0000-0002-9608-336X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05b8f4fac40b4da7a00e69b8451cb25b.json"}}, {"family": "Olsson", "given": "Cecilia", "initials": "C"}, {"family": "Tillfors", "given": "Maria", "initials": "M"}, {"family": "Melin-Johansson", "given": "Christina", "initials": "C"}, {"family": "\u00d6sterlind", "given": "Jane", "initials": "J"}, {"family": "Larsson", "given": "Maria", "initials": "M"}, {"family": "Hov", "given": "Reidun", "initials": "R"}, {"family": "Sandsdalen", "given": "Tuva", "initials": "T", "orcid": "0000-0002-6699-8059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6302338a98b0435b988f28517d845fd5.json"}}], "type": "journal article", "published": "2023-09-27", "journal": {"title": "J Multidiscip Healthc", "issn": "1178-2390", "issn-l": null, "volume": "16", "issue": null, "pages": "2893-2903"}, "abstract": "The provision of high-quality palliative care is challenging, especially during a pandemic like COVID-19. The latter entailed major consequences for health care systems and health care personnel (HCP) in both specialist and community health care services, in Norway and worldwide. The aim of this study was to explore how the HCP perceived the quality of palliative care in nursing homes, medical care units, and intensive care units during the COVID-19 pandemic.\r\n\r\nThis study had a cross-sectional design. A total of 290 HCP from Norway participated in the study (RR = 25.8%) between October and December 2021. The questionnaire comprised items concerning respondents' demographics and quality of care, the latter measured by the short form of the Quality from the Patient's Perspective-Palliative Care instrument, adapted for HCP. The STROBE checklist was used.\r\n\r\nThis study shows that the HCP scored subjective importance as higher in all dimensions, items and single items than their perception of the actual care received. This could indicate a need for improvement in all areas. Information about medication, opportunity to participate in decisions about medical and nursing care and continuity regarding receiving help from the same physician and nurse are examples of areas for improvement.\r\n\r\nStudy results indicate that HCP from nursing homes, medical care units, and intensive care units perceived that quality of palliative care provided was not in line with what they perceived to be important for the patient. This indicate that it was challenging to provide high-quality palliative care during the COVID-19 pandemic.", "doi": "10.2147/JMDH.S419442", "pmid": "37790989", "labels": {"Category: Social Science & Humanities": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10543989"}, {"db": "pii", "key": "419442"}], "notes": [], "created": "2023-11-01T13:33:07.426Z", "modified": "2023-11-02T07:12:31.702Z"}, {"entity": "publication", "iuid": "e318b799f41c458f80c14568469c767f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e318b799f41c458f80c14568469c767f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e318b799f41c458f80c14568469c767f"}}, "title": "Cognitive dysfunction in post-COVID-19 condition: Mechanisms, management, and rehabilitation.", "authors": [{"family": "M\u00f6ller", "given": "Marika", "initials": "M"}, {"family": "Borg", "given": "Kristian", "initials": "K"}, {"family": "Janson", "given": "Christer", "initials": "C"}, {"family": "Lerm", "given": "Maria", "initials": "M"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Niward", "given": "Katarina", "initials": "K"}], "type": "journal article", "published": "2023-09-27", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The long-term effects of COVID-19 on cognitive function have become an area of increasing concern. This paper provides an overview of characteristics, risk factors, possible mechanisms, and management strategies for cognitive dysfunction in post-COVID-19 condition (PCC). Prolonged cognitive dysfunction is one of the most common impairments in PCC, affecting between 17% and 28% of the individuals more than 12 weeks after the infection and persisting in some cases for several years. Cognitive dysfunctions can be manifested as a wide range of symptoms including memory impairment, attention deficit, executive dysfunction, and reduced processing speed. Risk factors for developing PCC, with or without cognitive impairments, include advanced age, preexisting medical conditions, and the severity of acute illness. The underlying mechanisms remain unclear, but proposed contributors include neuroinflammation, hypoxia, vascular damage, and latent virus reactivation not excluding the possibility of direct viral invasion of the central nervous system, illustrating complex viral pathology. As the individual variation of the cognitive impairments is large, a neuropsychological examination and a person-centered multidimensional approach are required. According to the World Health Organization, limited evidence on COVID-19-related cognitive impairments necessitates implementing rehabilitation interventions from established practices of similar conditions. Psychoeducation and compensatory skills training are recommended. Assistive products and environmental modifications adapted to individual needs might be helpful. In specific attention- and working memory dysfunctions, cognitive training-carefully monitored for intensity-might be effective for people who do not suffer from post-exertional malaise. Further research is crucial for evidence-based interventions specific to COVID-19-related cognitive impairments.", "doi": "10.1111/joim.13720", "pmid": "37766515", "labels": {"Category: Rehabilitation": null, "Category: Post-COVID": null, "Type: Review": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:55:23.836Z", "modified": "2023-10-06T10:52:52.998Z"}, {"entity": "publication", "iuid": "e1e6f31128384d6aab68ccc445739304", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e1e6f31128384d6aab68ccc445739304.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e1e6f31128384d6aab68ccc445739304"}}, "title": "SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood.", "authors": [{"family": "Lugar", "given": "Marija", "initials": "M"}, {"family": "Eugster", "given": "Anne", "initials": "A"}, {"family": "Achenbach", "given": "Peter", "initials": "P"}, {"family": "von dem Berge", "given": "Thekla", "initials": "T"}, {"family": "Berner", "given": "Reinhard", "initials": "R"}, {"family": "Besser", "given": "Rachel E J", "initials": "REJ"}, {"family": "Casteels", "given": "Kristina", "initials": "K"}, {"family": "Elding Larsson", "given": "Helena", "initials": "H"}, {"family": "Gemulla", "given": "Gita", "initials": "G"}, {"family": "Kordonouri", "given": "Olga", "initials": "O"}, {"family": "Lindner", "given": "Annett", "initials": "A"}, {"family": "Lundgren", "given": "Markus", "initials": "M"}, {"family": "M\u00fcller", "given": "Denise", "initials": "D"}, {"family": "Oltarzewski", "given": "Mariusz", "initials": "M"}, {"family": "Rochtus", "given": "Anne", "initials": "A"}, {"family": "Scholz", "given": "Marlon", "initials": "M"}, {"family": "Szypowska", "given": "Agnieszka", "initials": "A"}, {"family": "Todd", "given": "John A", "initials": "JA"}, {"family": "Ziegler", "given": "Anette-Gabriele", "initials": "A"}, {"family": "Bonifacio", "given": "Ezio", "initials": "E"}, {"family": "GPPAD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-09-26", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484", "volume": "330", "issue": "12", "pages": "1151-1160"}, "abstract": "The incidence of diabetes in childhood has increased during the COVID-19 pandemic. Elucidating whether SARS-CoV-2 infection is associated with islet autoimmunity, which precedes type 1 diabetes onset, is relevant to disease etiology and future childhood diabetes trends.\r\n\r\nTo determine whether there is a temporal relationship between SARS-CoV-2 infection and the development of islet autoimmunity in early childhood.\r\n\r\nBetween February 2018 and March 2021, the Primary Oral Insulin Trial, a European multicenter study, enrolled 1050 infants (517 girls) aged 4 to 7 months with a more than 10% genetically defined risk of type 1 diabetes. Children were followed up through September 2022.\r\n\r\nSARS-CoV-2 infection identified by SARS-CoV-2 antibody development in follow-up visits conducted at 2- to 6-month intervals until age 2 years from April 2018 through June 2022.\r\n\r\nThe development of multiple (\u22652) islet autoantibodies in follow-up in consecutive samples or single islet antibodies and type 1 diabetes. Antibody incidence rates and risk of developing islet autoantibodies were analyzed.\r\n\r\nConsent was obtained for 885 (441 girls) children who were included in follow-up antibody measurements from age 6 months. SARS-CoV-2 antibodies developed in 170 children at a median age of 18 months (range, 6-25 months). Islet autoantibodies developed in 60 children. Six of these children tested positive for islet autoantibodies at the same time as they tested positive for SARS-CoV-2 antibodies and 6 at the visit after having tested positive for SARS-CoV-2 antibodies. The sex-, age-, and country-adjusted hazard ratio for developing islet autoantibodies when the children tested positive for SARS-CoV-2 antibodies was 3.5 (95% CI, 1.6-7.7; P = .002). The incidence rate of islet autoantibodies was 3.5 (95% CI, 2.2-5.1) per 100 person-years in children without SARS-CoV-2 antibodies and 7.8 (95% CI, 5.3-19.0) per 100 person-years in children with SARS-CoV-2 antibodies (P = .02). Islet autoantibody risk in children with SARS-CoV-2 antibodies was associated with younger age (<18 months) of SARS-CoV-2 antibody development (HR, 5.3; 95% CI, 1.5-18.3; P = .009).\r\n\r\nIn young children with high genetic risk of type 1 diabetes, SARS-CoV-2 infection was temporally associated with the development of islet autoantibodies.", "doi": "10.1001/jama.2023.16348", "pmid": "37682551", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10523173"}, {"db": "pii", "key": "2809621"}], "notes": [], "created": "2023-10-06T06:52:51.234Z", "modified": "2023-10-06T09:57:19.959Z"}, {"entity": "publication", "iuid": "063d887726bc402ea8c328b197fd1246", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/063d887726bc402ea8c328b197fd1246.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/063d887726bc402ea8c328b197fd1246"}}, "title": "Risk factors for ventilator-associated lower respiratory tract infection in COVID-19, a retrospective multicenter cohort study in Sweden.", "authors": [{"family": "Forsberg", "given": "Gustaf", "initials": "G"}, {"family": "Taxbro", "given": "Knut", "initials": "K", "orcid": "0000-0001-8711-9044", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53d41b4a81184f4da24af4065e0371e1.json"}}, {"family": "Elander", "given": "Louise", "initials": "L"}, {"family": "Hanberger", "given": "H\u00e5kan", "initials": "H"}, {"family": "Berg", "given": "S\u00f6ren", "initials": "S"}, {"family": "Idh", "given": "Jonna", "initials": "J"}, {"family": "Berkius", "given": "Johan", "initials": "J"}, {"family": "Ekman", "given": "Andreas", "initials": "A", "orcid": "0000-0001-6939-3365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6d19bd5b69440dcbdb168c292ba435f.json"}}, {"family": "Hammarskj\u00f6ld", "given": "Fredrik", "initials": "F"}, {"family": "Niward", "given": "Katarina", "initials": "K"}, {"family": "Balkhed", "given": "\u00c5se \u00d6stholm", "initials": "\u00c5\u00d6"}], "type": "journal article", "published": "2023-09-26", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": null, "issue": null, "pages": null}, "abstract": "Ventilator-associated lower respiratory tract infections (VA-LRTI) increase morbidity and mortality in intensive care unit (ICU) patients. Higher incidences of VA-LRTI have been reported among COVID-19 patients requiring invasive mechanical ventilation (IMV). The primary objectives of this study were to describe clinical characteristics, incidence, and risk factors comparing patients who developed VA-LRTI to patients who did not, in a cohort of Swedish ICU patients with acute hypoxemic respiratory failure due to COVID-19. Secondary objectives were to decipher changes over the three initial pandemic waves, common microbiology and the effect of VA-LTRI on morbidity and mortality.\r\n\r\nWe conducted a multicenter, retrospective cohort study of all patients admitted to 10 ICUs in southeast Sweden between March 1, 2020 and May 31, 2021 because of acute hypoxemic respiratory failure due to COVID-19 and were mechanically ventilated for at least 48 h. The primary outcome was culture verified VA-LRTI. Patient characteristics, ICU management, clinical course, treatments, microbiological findings, and mortality were registered. Logistic regression analysis was conducted to determine risk factors for first VA-LRTI.\r\n\r\nOf a total of 536 included patients, 153 (28.5%) developed VA-LRTI. Incidence rate of first VA-LRTI was 20.8 per 1000 days of IMV. Comparing patients with VA-LRTI to those without, no differences in mortality, age, sex, or number of comorbidities were found. Patients with VA-LRTI had fewer ventilator-free days, longer ICU stay, were more frequently ventilated in prone position, received corticosteroids more often and were more frequently on antibiotics at intubation. Regression analysis revealed increased adjusted odds-ratio (aOR) for first VA-LRTI in patients treated with corticosteroids (aOR 2.64 [95% confidence interval [CI]] [1.31-5.74]), antibiotics at intubation (aOR 2.01 95% CI [1.14-3.66]), and days of IMV (aOR 1.05 per day of IMV, 95% CI [1.03-1.07]). Few multidrug-resistant pathogens were identified. Incidence of VA-LRTI increased from 14.5 per 1000 days of IMV during the first wave to 24.8 per 1000 days of IMV during the subsequent waves.\r\n\r\nWe report a high incidence of culture-verified VA-LRTI in a cohort of critically ill COVID-19 patients from the first three pandemic waves. VA-LRTI was associated with increased morbidity but not 30-, 60-, or 90-day mortality. Corticosteroid treatment, antibiotics at intubation and time on IMV were associated with increased aOR of first VA-LRTI.", "doi": "10.1111/aas.14338", "pmid": "37751991", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:56:11.830Z", "modified": "2023-10-06T11:13:26.767Z"}, {"entity": "publication", "iuid": "15bb56bcd03e462bb05082b9dfbfffd4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15bb56bcd03e462bb05082b9dfbfffd4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15bb56bcd03e462bb05082b9dfbfffd4"}}, "title": "Outpatient Treatment with AZD7442 (Tixagevimab/Cilgavimab) Prevented COVID-19 Hospitalizations over 6 Months and Reduced Symptom Progression in the TACKLE Randomized Trial.", "authors": [{"family": "Hobbs", "given": "F D Richard", "initials": "FDR"}, {"family": "Montgomery", "given": "Hugh", "initials": "H"}, {"family": "Padilla", "given": "Francisco", "initials": "F"}, {"family": "Sim\u00f3n-Campos", "given": "Jesus Abraham", "initials": "JA"}, {"family": "Kim", "given": "Kenneth", "initials": "K"}, {"family": "Arbetter", "given": "Douglas", "initials": "D"}, {"family": "Padilla", "given": "Kelly W", "initials": "KW"}, {"family": "Reddy", "given": "Venkatesh Pilla", "initials": "VP"}, {"family": "Seegobin", "given": "Seth", "initials": "S"}, {"family": "Streicher", "given": "Katie", "initials": "K"}, {"family": "Templeton", "given": "Alison", "initials": "A"}, {"family": "Viani", "given": "Rolando M", "initials": "RM"}, {"family": "Johnsson", "given": "Eva", "initials": "E"}, {"family": "Koh", "given": "Gavin C K W", "initials": "GCKW"}, {"family": "Esser", "given": "Mark T", "initials": "MT"}], "type": "journal article", "published": "2023-09-26", "journal": {"title": "Infect Dis Ther", "issn": "2193-8229", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "We assessed effects of AZD7442 (tixagevimab/cilgavimab) on deaths from any cause or hospitalizations due to coronavirus disease 2019 (COVID-19) and symptom severity and longer-term safety in the TACKLE adult outpatient treatment study.\r\n\r\nParticipants received 600 mg AZD7442 (n = 452) or placebo (n = 451) \u2264 7 days of COVID-19 symptom onset.\r\n\r\nDeath from any cause or hospitalization for COVID-19 complications or sequelae through day 169 (key secondary endpoint) occurred in 20/399 (5.0%) participants receiving AZD7442 versus 40/407 (9.8%) receiving placebo [relative risk reduction (RRR) 49.1%; 95% confidence interval (CI) 14.5, 69.7; p = 0.009] or 50.7% (95% CI 17.5, 70.5; p = 0.006) after excluding participants unblinded before day 169 for consideration of vaccination). AZD7442 reduced progression of COVID-19 symptoms versus placebo through to day 29 (RRR 12.5%; 95% CI 0.5, 23.0) and improved most symptoms within 1-2 weeks. Over median safety follow-up of 170 days, adverse events occurred in 174 (38.5%) and 196 (43.5%) participants receiving AZD7442 or placebo, respectively. Cardiac serious adverse events occurred in two (0.4%) and three (0.7%) participants receiving AZD7442 or placebo, respectively.\r\n\r\nAZD7442 was well tolerated and reduced hospitalization and mortality through 6 months, and symptom burden through 29 days, in outpatients with mild-to-moderate COVID-19.\r\n\r\nClinicaltrials.gov, NCT04723394. ( https://beta.\r\n\r\ngov/study/NCT04723394 ).", "doi": "10.1007/s40121-023-00861-7", "pmid": "37751015", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40121-023-00861-7"}, {"db": "ClinicalTrials.gov", "key": "NCT04723394"}], "notes": [], "created": "2023-10-06T06:56:24.780Z", "modified": "2023-10-06T11:17:53.372Z"}, {"entity": "publication", "iuid": "d2b12b12e20c4ab0b118cffb5ad29b1a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d2b12b12e20c4ab0b118cffb5ad29b1a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d2b12b12e20c4ab0b118cffb5ad29b1a"}}, "title": "New-Onset Diabetes Mellitus in COVID-19: A Scoping Review.", "authors": [{"family": "Pantea Stoian", "given": "Anca", "initials": "A"}, {"family": "Bica", "given": "Ioana-Cristina", "initials": "I"}, {"family": "Salmen", "given": "Teodor", "initials": "T"}, {"family": "Al Mahmeed", "given": "Wael", "initials": "W"}, {"family": "Al-Rasadi", "given": "Khalid", "initials": "K"}, {"family": "Al-Alawi", "given": "Kamila", "initials": "K"}, {"family": "Banach", "given": "Maciej", "initials": "M"}, {"family": "Banerjee", "given": "Yajnavalka", "initials": "Y"}, {"family": "Ceriello", "given": "Antonio", "initials": "A"}, {"family": "Cesur", "given": "Mustafa", "initials": "M"}, {"family": "Cosentino", "given": "Francesco", "initials": "F"}, {"family": "Firenze", "given": "Alberto", "initials": "A"}, {"family": "Galia", "given": "Massimo", "initials": "M"}, {"family": "Goh", "given": "Su-Yen", "initials": "S"}, {"family": "Janez", "given": "Andrej", "initials": "A"}, {"family": "Kalra", "given": "Sanjay", "initials": "S"}, {"family": "Kapoor", "given": "Nitin", "initials": "N"}, {"family": "Kempler", "given": "Peter", "initials": "P"}, {"family": "Lessan", "given": "Nader", "initials": "N"}, {"family": "Lotufo", "given": "Paulo", "initials": "P"}, {"family": "Mikhaildiis", "given": "Dimitri P", "initials": "DP"}, {"family": "Nibali", "given": "Luigi", "initials": "L"}, {"family": "Papanas", "given": "Nikolaos", "initials": "N"}, {"family": "Powell-Wiley", "given": "Tiffany", "initials": "T"}, {"family": "Rizvi", "given": "Ali A", "initials": "AA"}, {"family": "Sahebkar", "given": "Amirhossein", "initials": "A"}, {"family": "Santos", "given": "Raul D", "initials": "RD"}, {"family": "Toth", "given": "Peter P", "initials": "PP"}, {"family": "Viswanathan", "given": "Vijay", "initials": "V"}, {"family": "Rizzo", "given": "Manfredi", "initials": "M"}, {"family": "Cardiometabolic Panel of International Experts on Syndemic COVID-19 (CAPISCO)", "given": "", "initials": ""}], "type": "journal article", "published": "2023-09-26", "journal": {"title": "Diabetes Ther", "issn": "1869-6953", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic became superimposed on the pre-existing obesity and diabetes mellitus (DM) pandemics. Since COVID-19 infection alters the metabolic equilibrium, it may induce pathophysiologic mechanisms that potentiate new-onset DM, and we evaluated this issue.\r\n\r\nA systematic review of the literature published from the 1 January 2020 until the 20 July 2023 was performed (PROSPERO registration number CRD42022341638). We included only full-text articles of both human clinical and randomized controlled trials published in English and enrolling adults (age > 18 years old) with ongoing or preceding COVID-19 in whom hyperglycemia was detected. The search was based on the following criteria: \"(new-onset diabetes mellitus OR new-onset DM) AND (COVID-19) AND adults\".\r\n\r\nArticles on MEDLINE (n = 70) and the Web of Science database (n = 16) were included and analyzed by two researchers who selected 20 relevant articles. We found evidence of a bidirectional relationship between COVID-19 and DM.\r\n\r\nThis link operates as a pathophysiological mechanism supported by epidemiological data and also by the clinical and biological findings obtained from the affected individuals. The COVID-19 pandemic raised the incidence of DM through different pathophysiological and psychosocial factors.", "doi": "10.1007/s13300-023-01465-7", "pmid": "37751143", "labels": {"Category: Health": null, "Category: Post-COVID": null, "Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s13300-023-01465-7"}], "notes": [], "created": "2023-10-06T06:56:19.951Z", "modified": "2023-10-06T11:16:20.895Z"}, {"entity": "publication", "iuid": "857986e34e8c45918f8e99832b77fba3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/857986e34e8c45918f8e99832b77fba3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/857986e34e8c45918f8e99832b77fba3"}}, "title": "Effects of remdesivir on SARS-CoV-2 viral dynamics and mortality in viraemic patients hospitalized for COVID-19.", "authors": [{"family": "Hagman", "given": "Karl", "initials": "K", "orcid": "0000-0002-5965-6130", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f57f6a390d6f4000ab75562643872ef7.json"}}, {"family": "Hedenstierna", "given": "Magnus", "initials": "M", "orcid": "0000-0001-8539-9820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/561a8bfc411142ab8dc9c4e1bffa93da.json"}}, {"family": "Widaeus", "given": "Jacob", "initials": "J"}, {"family": "Arvidsson", "given": "Emelie", "initials": "E"}, {"family": "Hammas", "given": "Berit", "initials": "B"}, {"family": "Grillner", "given": "Lena", "initials": "L"}, {"family": "Jakobsson", "given": "Jan", "initials": "J", "orcid": "0000-0002-5829-1803", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/940a993e912e4b6e98b913efe6c0c08d.json"}}, {"family": "Gille-Johnson", "given": "Patrik", "initials": "P"}, {"family": "Ursing", "given": "Johan", "initials": "J", "orcid": "0000-0002-5508-9327", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88f0c4ae034f4078869e7b9e85ff2d4e.json"}}], "type": "journal article", "published": "2023-09-26", "journal": {"title": "J Antimicrob Chemother", "issn": "1460-2091", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Studies on the antiviral effects of remdesivir have shown conflicting results. SARS-CoV-2 viraemia could identify patients in whom antiviral treatment may be particularly beneficial.\r\n\r\nTo investigate antiviral effects and clinical outcomes of remdesivir treatment in viraemic patients.\r\n\r\nViraemic patients hospitalized for COVID-19 with ratio of arterial oxygen partial pressure to fractional inspired oxygen of \u2264300, symptom duration \u226410 days, and estimated glomerular filtration rate \u226530 mL/min were included in a cohort. The rate of serum viral clearance and serum viral load decline, 60 day mortality and in-hospital outcomes were estimated. A subgroup analysis including patients with symptom duration \u22647 days was performed.\r\n\r\nA total of 318 viraemic patients were included. Thirty-three percent (105/318) received remdesivir. The rate of serum viral clearance [subhazard risk ratio (SHR) 1.4 (95% CI 0.9-2.0), P = 0.11] and serum viral load decline (P = 0.11) were not significantly different between remdesivir-treated patients and controls. However, the rate of serum viral clearance was non-significantly higher [SHR 1.6 (95% CI 1.0-2.7), P = 0.051] and the viral load decline was faster (P = 0.03) in remdesivir-treated patients with symptom duration \u22647 days at admission. The 60 day mortality [HR 1.0 (95% CI 0.6-1.8), P = 0.97] and adverse in-hospital outcomes [OR 1.4 (95% CI 0.8-2.4), P = 0.31] were not significantly different between remdesivir-treated patients and controls.\r\n\r\nRemdesivir treatment did not significantly change the duration of SARS-CoV-2 viraemia, decline of serum viral load, 60 day mortality or in-hospital adverse outcomes in patients with \u226410 days of symptoms at admission. Remdesivir appeared to reduce the duration of viraemia in a subgroup of patients with \u22647 days of symptoms at admission.", "doi": "10.1093/jac/dkad295", "pmid": "37757451", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7283037"}], "notes": [], "created": "2023-10-06T06:53:00.945Z", "modified": "2023-10-06T10:44:02.277Z"}, {"entity": "publication", "iuid": "7b077a08a6e844f7990e9a5e1d9f9d1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b077a08a6e844f7990e9a5e1d9f9d1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b077a08a6e844f7990e9a5e1d9f9d1d"}}, "title": "De novo design of anti-variant COVID-19 vaccine.", "authors": [{"family": "Goswami", "given": "Arpita", "initials": "A", "orcid": "0000-0001-5632-1610", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4b47cfbebb0432ab41fd84d5d227da6.json"}}, {"family": "Kumar", "given": "Madan", "initials": "M"}, {"family": "Ullah", "given": "Samee", "initials": "S", "orcid": "0000-0003-1987-3672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eca60a20784249e9a7ac35c2b394c79b.json"}}, {"family": "Gore", "given": "Milind M", "initials": "MM"}], "type": "journal article", "published": "2023-09-26", "journal": {"title": "Biol Methods Protoc", "issn": "2396-8923", "issn-l": null, "volume": "8", "issue": "1", "pages": "bpad021"}, "abstract": "Recent studies highlight the effectiveness of hybrid Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) vaccines combining wild-type nucleocapsid and Spike proteins. We have further enhanced this strategy by incorporating delta and omicron variants' spike protein mutations. Both delta and omicron mark the shifts in viral transmissibility and severity in unvaccinated and vaccinated patients. So their mutations are highly crucial for future viral variants also. Omicron is particularly adept at immune evasion by mutating spike epitopes. The rapid adaptations of Omicron and sub-variants to spike-based vaccines and simultaneous transmissibility underline the urgency for new vaccines in the continuous battle against SARS-CoV-2. Therefore, we have added three persistent T-cell-stimulating nucleocapsid peptides similar to homologous sequences from seasonal Human Coronaviruses (HuCoV) and an envelope peptide that elicits a strong T-cell immune response. These peptides are clustered in the hybrid spike's cytoplasmic region with non-immunogenic linkers, enabling systematic arrangement. AlphaFold (Artificial intelligence-based model building) analysis suggests omitting the transmembrane domain enhances these cytoplasmic epitopes' folding efficiency which can ensure persistent immunity for CD4+ structural epitopes. Further molecular dynamics simulations validate the compact conformation of the modeled structures and a flexible C-terminus region. Overall, the structures show stability and less conformational fluctuation throughout the simulation. Also, the AlphaFold predicted structural epitopes maintained their folds during simulation to ensure the specificity of CD4+ T-cell response after vaccination. Our proposed approach may provide options for incorporating diverse anti-viral T-cell peptides, similar to HuCoV, into linker regions. This versatility can be promising to address outbreaks and challenges posed by various viruses for effective management in this era of innovative vaccines.", "doi": "10.1093/biomethods/bpad021", "pmid": "37854896", "labels": {"Category: Proteins": null, "Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10580973"}, {"db": "pii", "key": "bpad021"}], "notes": [], "created": "2023-11-01T13:34:12.261Z", "modified": "2023-11-02T07:44:07.338Z"}, {"entity": "publication", "iuid": "79fe4e4fd2ff463795217ce03e9c6ffc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79fe4e4fd2ff463795217ce03e9c6ffc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79fe4e4fd2ff463795217ce03e9c6ffc"}}, "title": "Comprehensive proteomics and meta-analysis of COVID-19 host response.", "authors": [{"family": "Baba\u010di\u0107", "given": "Haris", "initials": "H", "orcid": "0000-0003-0813-0005", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd5aeeb249db49e08f44314024fae6ef.json"}}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f2dc27d02294a15a6f691be6aab641f.json"}}, {"family": "Ara\u00fajo", "given": "Jos\u00e9 Eduardo", "initials": "JE"}, {"family": "Mermelekas", "given": "Georgios", "initials": "G"}, {"family": "Sharma", "given": "Nidhi", "initials": "N"}, {"family": "Tynell", "given": "Janne", "initials": "J", "orcid": "0000-0001-6930-5230", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/239eab38958f497f9162b6f37610ab73.json"}}, {"family": "Garc\u00eda", "given": "Marina", "initials": "M", "orcid": "0000-0002-9130-3933", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5b109d7a54e4c05a48e0f21c4432be6.json"}}, {"family": "Varnaite", "given": "Renata", "initials": "R"}, {"family": "Asgeirsson", "given": "Hilmir", "initials": "H", "orcid": "0000-0003-3869-8021", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/870e3520475b41f8a4f39744b1ecb3ea.json"}}, {"family": "Glans", "given": "Hedvig", "initials": "H"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J", "orcid": "0000-0002-8100-9562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4eb7262dfac84b819fe79856e96eaf76.json"}}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Pernemalm", "given": "Maria", "initials": "M", "orcid": "0000-0003-4624-031X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6801d3242ee544a59d77ccd7256a4a30.json"}}], "type": "meta-analysis", "published": "2023-09-22", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "14", "issue": "1", "pages": "5921"}, "abstract": "COVID-19 is characterised by systemic immunological perturbations in the human body, which can lead to multi-organ damage. Many of these processes are considered to be mediated by the blood. Therefore, to better understand the systemic host response to SARS-CoV-2 infection, we performed systematic analyses of the circulating, soluble proteins in the blood through global proteomics by mass-spectrometry (MS) proteomics. Here, we show that a large part of the soluble blood proteome is altered in COVID-19, among them elevated levels of interferon-induced and proteasomal proteins. Some proteins that have alternating levels in human cells after a SARS-CoV-2 infection in vitro and in different organs of COVID-19 patients are deregulated in the blood, suggesting shared infection-related changes.The availability of different public proteomic resources on soluble blood proteome alterations leaves uncertainty about the change of a given protein during COVID-19. Hence, we performed a systematic review and meta-analysis of MS global proteomics studies of soluble blood proteomes, including up to 1706 individuals (1039 COVID-19 patients), to provide concluding estimates for the alteration of 1517 soluble blood proteins in COVID-19. Finally, based on the meta-analysis we developed CoViMAPP, an open-access resource for effect sizes of alterations and diagnostic potential of soluble blood proteins in COVID-19, which is publicly available for the research, clinical, and academic community.", "doi": "10.1038/s41467-023-41159-z", "pmid": "37739942", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Other": null, "Funder: KAW/SciLifeLab": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC10516886"}, {"db": "pii", "key": "10.1038/s41467-023-41159-z"}], "notes": [], "created": "2023-10-06T06:52:08.783Z", "modified": "2023-10-06T08:17:43.169Z"}, {"entity": "publication", "iuid": "6df48cf185f94d4d8d35cfe2c6b33d1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6df48cf185f94d4d8d35cfe2c6b33d1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6df48cf185f94d4d8d35cfe2c6b33d1d"}}, "title": "What Is the Impact of the Novel Coronavirus and the Vaccination on Guillain-Barre Syndrome?", "authors": [{"family": "Chen", "given": "Yinuo", "initials": "Y"}, {"family": "Li", "given": "Kezheng", "initials": "K"}, {"family": "Lv", "given": "Wenjing", "initials": "W"}, {"family": "Xie", "given": "Jiali", "initials": "J"}, {"family": "Qian", "given": "Yuqin", "initials": "Y"}, {"family": "Cui", "given": "Can", "initials": "C"}, {"family": "Deng", "given": "Binbin", "initials": "B", "orcid": "0000-0002-4058-0738", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/592a6c15241f467cb88b21a1853ed8be.json"}}], "type": "journal article", "published": "2023-09-20", "journal": {"title": "Mol Neurobiol", "issn": "1559-1182", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has resulted in devastating medical and economic consequences worldwide over the past 3 years. As the pandemic enters a new stage, it is essential to consider the potential impact on rare diseases such as Guillain-Barre syndrome (GBS), which has been intimately associated with COVID-19 since the first COVID-19-related GBS case was reported in January 2020. There are notable differences between COVID-19-related GBS and GBS without COVID-19 in terms of diagnostic types and clinical manifestations. Furthermore, with the widespread administration of COVID-19 vaccines, there have been reports of GBS occurring shortly after vaccination, which requires close attention despite its rarity. This review also explores the vaccines associated with heightened GBS risks, offering insights that may guide vaccination policies and clinical practice. To provide a visual summary of these findings, we have included a graphical abstract. This article will discuss the characteristic manifestations of GBS patients after being positive for the novel coronavirus and the safety of several COVID-19 vaccines. Firstly, this article comprehensively expounds and discusses the epidemiological aspects of novel coronavirus-related GBS. For example, from the perspective of the same population, the expected incidence of GBS in the COVID-19-positive population (persons/100,000 persons/ year) is about 43 times that of the COVID-19-negative population, and the incidence of GBS is significantly increased. Secondly, the clinical characteristics of COVID-19-negative GBS patients and SARS-CoV-2-GBS (SC2-GBS) patients were summarized and compared. Thirdly, this article reviews GBS cases in the current adverse events after COVID-19 vaccination and analyzes and discusses from multiple perspectives, such as the incidence of GBS events, the age proportion of patients, and the interval of onset.", "doi": "10.1007/s12035-023-03638-8", "pmid": "37728848", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "10.1007/s12035-023-03638-8"}], "notes": [], "created": "2023-10-06T06:52:20.586Z", "modified": "2023-10-06T08:47:40.883Z"}, {"entity": "publication", "iuid": "9fab0e58ed044f48bdcf82502fdbfc0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9fab0e58ed044f48bdcf82502fdbfc0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9fab0e58ed044f48bdcf82502fdbfc0e"}}, "title": "Strict self-isolation did not protect Swedish cancer patients on active treatment from the risk of becoming seropositive for SARS-CoV-2.", "authors": [{"family": "Ginman", "given": "Beatrice", "initials": "B"}, {"family": "Pahnke", "given": "Simon", "initials": "S", "orcid": "0000-0002-3541-2027", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f7056035dab4a0080d35b40977463a8.json"}}, {"family": "Freyhult", "given": "Eva", "initials": "E"}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Kolstad", "given": "Linda", "initials": "L"}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Hamberg Levedahl", "given": "Kerstin", "initials": "K"}, {"family": "Enblad", "given": "Gunilla", "initials": "G"}, {"family": "Glimelius", "given": "Ingrid", "initials": "I", "orcid": "0000-0001-6158-3041", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4407b480fb244249063d1cc74513c67.json"}}], "type": "journal article", "published": "2023-09-20", "journal": {"title": "Acta Oncol", "issn": "1651-226X", "issn-l": null, "volume": null, "issue": null, "pages": "1-9"}, "abstract": "Background: Swedish recommendations to reduce the risk of COVID-19 relied on each citizen's own sense of responsibility rather than mandatory lockdowns. We studied how COVID-19-related self-isolation and anxiety correlated to SARS-CoV-2 seropositivity and PCR-positivity in patients with active cancer treatment.Methods: In a longitudinal cohort study at Uppsala University Hospital patients and cancer personnel were included between April 1st 2020 to August 1st 2020. Serological testing for SARS-CoV-2 was done every 8-12-weeks until 30 March 2021. Patients completed a survey at inclusion regarding self-reported COVID-19-related anxiety and self-isolation.Results: A total of 622 patients [n = 475 with solid malignancies (SM), n = 147 with haematological malignancies (HM)], and 358 healthcare personnel were included. The seropositivity rate was lower for patients than for personnel; 10.5% for SM patients, 6.8% for HM patients, and 16.2% for personnel (p = 0.005). Strict adherence to self-isolation guidelines was reported by 54% of patients but was not associated with a lower risk of becoming seropositive [OR = 1.4 (0.8-2.5), p = 0.2]. High anxiety was expressed by 32% of patients, more often by SM patients than HM patients (34% vs 25% [OR = 1.6 (1.1-2.5, p = 0.03)]). Female gender [OR = 3.5 (2.4-5.2), p < 0.001] and being born outside of Europe [OR = 2.9 (1.4-6.4), p = 0.007] were both associated with high anxiety. Patients reporting high anxiety became seropositive to a similar degree as those with low anxiety [OR = 0.7 (0.3-1.2), p = 0.2]. HM patients with PCR-positive COVID-19 were more likely than SM patients to require oxygen therapy, including non-invasive ventilation/intubation (69% vs. 26%, p = 0.005).Conclusion: For Swedish patients on active cancer treatment, high self-assessed COVID-19-related anxiety or strict adherence to self-isolation guidelines were not associated with a lower risk of COVID-19. Patients with HM were less likely to develop serological antibody response after COVID-19 and were more likely to require advanced hospital care, but expressed less COVID-19-related anxiety than patients with SM.", "doi": "10.1080/0284186X.2023.2257873", "pmid": "37729083", "labels": {"Category: Health": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Social Science & Humanities": null, "Category: Serology": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:52:22.926Z", "modified": "2023-10-06T08:49:11.876Z"}, {"entity": "publication", "iuid": "4260eeddc24f443e8616014380ebb666", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4260eeddc24f443e8616014380ebb666.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4260eeddc24f443e8616014380ebb666"}}, "title": "Predictors of the post-COVID condition following mild SARS-CoV-2 infection.", "authors": [{"family": "Reme", "given": "B-A", "initials": "B"}, {"family": "Gjesvik", "given": "J", "initials": "J"}, {"family": "Magnusson", "given": "K", "initials": "K", "orcid": "0000-0003-4851-5794", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2fe6a28f36f40a998b8c9fc3c5ebe73.json"}}], "type": "journal article", "published": "2023-09-20", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "14", "issue": "1", "pages": "5839"}, "abstract": "Whereas the nature of the post-COVID condition following mild acute COVID-19 is increasingly well described in the literature, knowledge of its risk factors, and whether it can be predicted, remains limited. This study, conducted in Norway, uses individual-level register data from 214,667 SARS-CoV-2 infected individuals covering a range of demographic, socioeconomic factors, as well as cause-specific healthcare utilization in the years prior to infection to assess the risk of post-COVID complaints \u22653 months after testing positive. We find that the risk of post-COVID was higher among individuals who prior to infection had been diagnosed with psychological (OR = 2.12, 95% CI 1.84-2.44), respiratory (OR = 2.03, 95% CI 1.78-2.32), or general and unspecified health problems (OR = 1.78, 95% CI 1.52-2.09). To assess the predictability of post-COVID after mild initial disease, we use machine learning methods and find that pre-infection characteristics, combined with information on the SARS-CoV-2 virus type and vaccine status, to a considerable extent (AUC = 0.79, 95% CI 0.75-0.81) could predict the occurrence of post-COVID complaints in our sample.", "doi": "10.1038/s41467-023-41541-x", "pmid": "37730740", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC10511472"}, {"db": "pii", "key": "10.1038/s41467-023-41541-x"}], "notes": [], "created": "2023-10-06T12:26:24.681Z", "modified": "2023-10-06T12:32:45.559Z"}, {"entity": "publication", "iuid": "07d0b69a0592471ba8f3f12bccd0b798", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07d0b69a0592471ba8f3f12bccd0b798.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07d0b69a0592471ba8f3f12bccd0b798"}}, "title": "Mental health, stress, and well-being measured before (2019) and during (2020) COVID-19: a Swedish socioeconomic population-based study.", "authors": [{"family": "Lindqvist Bagge", "given": "Ann-Sophie", "initials": "A"}, {"family": "Lekander", "given": "Mats", "initials": "M", "orcid": "0000-0003-3998-1494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e04a9b05c67472980549da294267381.json"}}, {"family": "Olofsson Bagge", "given": "Roger", "initials": "R", "orcid": "0000-0001-5795-0355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0502c52a1b65446fa2e4b726906c9d51.json"}}, {"family": "Carlander", "given": "Anders", "initials": "A", "orcid": "0000-0002-4435-7648", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb81228e2951462ab407f261fa9e6d02.json"}}], "type": "journal article", "published": "2023-09-20", "journal": {"title": "Psychol Health", "issn": "1476-8321", "issn-l": null, "volume": null, "issue": null, "pages": "1-18"}, "abstract": "Compare mental health, stress, and well-being in the Swedish population as measured before and during the COVID-19 pandemic.\r\n\r\nRepeated cross-sectional design using data measured before (Jan-2019; n = 2791) and during (Oct/Nov-2020; n = 2926) COVID-19 pandemic in Swedish population-representative cohorts. Following constructs were measured: anxiety (Beck Anxiety Inventory), depression (Beck Depression Inventory-II), stress (Perceived Stress Scale-10 items), health-related quality of life (HRQOL[Functional Assessment of Cancer Therapy-General Population]) and self-rated health (SRH) was assessed with a single-item question.\r\n\r\nWhen adjusting for age, sex, education, and income there were significantly higher levels of anxiety (M\u0302 = 9.15 vs. 8.48, p < 0.01) and depression (M\u0302 = 3.64 vs. 3.30, p = 0.03), lower levels of stress (M\u0302 = 14.06 vs. 14.91, p < 0.001), but worsened HRQOL (M\u0302 = 76.40 vs. 77.92, p < 0.01) and SRH (M\u0302 = 6.91 vs. 7.20, p < 0.001), observed in 2020 compared to 2019. For the negative effects seen in anxiety, depression, HRQOL, and SRH, higher income and education had a protective effect. The decrease in stress was also correlated with higher income.\r\n\r\nThe COVID-19 pandemic led to a small but significant worsening in mental health and well-being in the general Swedish population, where higher socioeconomic status seemed to have a protective effect.", "doi": "10.1080/08870446.2023.2257747", "pmid": "37728316", "labels": {"Type: Journal article": null, "Funder: Forte": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:56:02.078Z", "modified": "2023-10-06T10:58:34.391Z"}, {"entity": "publication", "iuid": "c7faff32e1944754ad92588bd7d575fe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7faff32e1944754ad92588bd7d575fe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7faff32e1944754ad92588bd7d575fe"}}, "title": "Prevalence and impact of chronic dysglycaemia among patients with COVID-19 in Swedish intensive care units: a multicentre, retrospective cohort study.", "authors": [{"family": "Balintescu", "given": "Anca", "initials": "A", "orcid": "0000-0001-8665-5742", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/97e90fbd52e64ac7b6d6dbd91a2db88c.json"}}, {"family": "Rysz", "given": "Susanne", "initials": "S"}, {"family": "Hertz", "given": "Carl", "initials": "C"}, {"family": "Grip", "given": "Jonathan", "initials": "J"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Oldner", "given": "Anders", "initials": "A"}, {"family": "Svensen", "given": "Christer", "initials": "C"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}], "type": "observational study", "published": "2023-09-19", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "9", "pages": "e071330"}, "abstract": "Using glycated haemoglobin A1c (HbA1c) screening, we aimed to determine the prevalence of chronic dysglycaemia among patients with COVID-19 admitted to the intensive care unit (ICU). Additionally, we aimed to explore the association between chronic dysglycaemia and clinical outcomes related to ICU stay.\r\n\r\nMulticentre retrospective observational study.\r\n\r\nICUs in three hospitals in Stockholm, Sweden.\r\n\r\nCOVID-19 patients admitted to the ICU between 5 March 2020 and 13 August 2020 with available HbA1c at admission. Chronic dysglycaemia was determined based on previous diabetes history and HbA1c.\r\n\r\nPrimary outcome was the actual prevalence of chronic dysglycaemia (pre-diabetes, unknown diabetes or known diabetes) among COVID-19 patients. Secondary outcome was the association of chronic dysglycaemia with 90-day mortality, ICU length of stay, duration of invasive mechanical ventilation (IMV) and renal replacement therapy (RRT), accounting for treatment selection bias.\r\n\r\nA total of 308 patients with available admission HbA1c were included. Chronic dysglycaemia prevalence assessment was restricted to 206 patients admitted ICUs in which HbA1c was measured on all admitted patients. Chronic dysglycaemia was present in 82.0% (95% CI 76.1% to 87.0%) of patients, with pre-diabetes present in 40.2% (95% CI 33.5% to 47.3%), unknown diabetes in 20.9% (95% CI 15.5% to 27.1%), well-controlled diabetes in 7.8% (95% CI 4.5% to 12.3%) and uncontrolled diabetes in 13.1% (95% CI 8.8% to 18.5%). All patients with available HbA1c were included for the analysis of the relationship between chronic dysglycaemia and secondary outcomes. We found no independent association between chronic dysglycaemia and 90-day mortality, ICU length of stay or duration of IMV. After excluding patients with specific treatment limitations, no association between chronic dysglycaemia and RRT use was observed.\r\n\r\nIn our cohort of critically ill COVID-19 patients, the prevalence of chronic dysglycaemia was 82%. We found no robust associations between chronic dysglycaemia and clinical outcomes when accounting for treatment limitations.", "doi": "10.1136/bmjopen-2022-071330", "pmid": "37730398", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10510869"}, {"db": "pii", "key": "bmjopen-2022-071330"}], "notes": [], "created": "2023-10-06T06:56:14.282Z", "modified": "2023-10-06T11:14:23.235Z"}, {"entity": "publication", "iuid": "f33ccda0af204b66985f5a33d4c2b538", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f33ccda0af204b66985f5a33d4c2b538.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f33ccda0af204b66985f5a33d4c2b538"}}, "title": "The effect of COVID-19 pandemic on perioperative factors: data from the Swedish Perioperative Register.", "authors": [{"family": "Dahlberg", "given": "Karuna", "initials": "K"}, {"family": "M\u00e5nsson", "given": "Sandra", "initials": "S"}, {"family": "Lyckner", "given": "Sara", "initials": "S"}, {"family": "Lindgren", "given": "Lenita", "initials": "L"}, {"family": "Alm", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2023-09-16", "journal": {"title": "Perioper Med (Lond)", "issn": "2047-0525", "issn-l": null, "volume": "12", "issue": "1", "pages": "50"}, "abstract": "The COVID-19 pandemic has affected healthcare organizations in many areas. The aim of this study was to describe surgical interventions, anesthesia, and postoperative outcomes in adult patients during the first wave and 1 year into the COVID-19 pandemic in Sweden, and to compare these outcomes with outcomes during the same period the year before the pandemic.\r\n\r\nData were collected from the Swedish PeriOperative Register, and included 417, 233 perioperative registration of patients \u2265 18 years old between period 1 (March-June 2019), period 2 (March-June 2020), and period 3 (March-June 2021).\r\n\r\nCompared with pre-pandemic (period 1), the number of surgical interventions decreased by 28% in the first wave (period 2); 1 year into the pandemic (period 3), the number of interventions was still 7.5% lower than pre-pandemic. The largest drops between periods 1 and 2 were noted in the specialties of ear, nose, and larynx surgery, - 55.6%; teeth, jaws, mouth, and pharynx surgery, - 45.0%; endocrine system surgery, - 38.8%. The number of acute surgeries remained stable during all three periods. Volatiles were more frequently used for the maintenance of general anesthesia in period 2 than in either period 1 or 3 (p < 0.001). Minor differences were noted throughout the periods in postoperative nausea and vomiting as well as postoperative pain.\r\n\r\nThe COVID-19 pandemic has had an impact on perioperative care in Sweden. During the first wave of the pandemic, the number of surgical interventions decreased, but the number of acute surgeries remained stable compared with pre-pandemic numbers. Perioperative organizations have had and will continue to have challenges handling the increased number of patients needing perioperative care.", "doi": "10.1186/s13741-023-00340-0", "pmid": "37715220", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10504757"}, {"db": "pii", "key": "10.1186/s13741-023-00340-0"}], "notes": [], "created": "2023-10-06T06:56:04.609Z", "modified": "2023-10-06T11:03:20.841Z"}, {"entity": "publication", "iuid": "3ad2fcacd1ce42d7b2baae5a8fdf22d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ad2fcacd1ce42d7b2baae5a8fdf22d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ad2fcacd1ce42d7b2baae5a8fdf22d5"}}, "title": "3D printed fluidic swab for COVID-19 testing with improved diagnostic yield and user comfort.", "authors": [{"family": "Kim", "given": "Joochan", "initials": "J"}, {"family": "Jeon", "given": "Jaehyung", "initials": "J"}, {"family": "Jang", "given": "Hyowon", "initials": "H"}, {"family": "Moon", "given": "Youngkwang", "initials": "Y"}, {"family": "Abafogi", "given": "Abdurhaman Teyib", "initials": "AT"}, {"family": "van Noort", "given": "Danny", "initials": "D"}, {"family": "Lee", "given": "Jinkee", "initials": "J"}, {"family": "Kang", "given": "Taejoon", "initials": "T"}, {"family": "Park", "given": "Sungsu", "initials": "S", "orcid": "0000-0003-3062-1302", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b28d5fc9ffb046f7abe638dafddade3d.json"}}], "type": "journal article", "published": "2023-09-16", "journal": {"title": "Nano Converg", "issn": "2196-5404", "issn-l": null, "volume": "10", "issue": "1", "pages": "45"}, "abstract": "The current standard method of diagnosing coronavirus disease 2019 (COVID-19) involves uncomfortable and invasive nasopharyngeal (NP) sampling using cotton swabs (CS), which can be unsuitable for self-testing. Although mid-turbinate sampling is an alternative, it has a lower diagnostic yield than NP sampling. Nasal wash (NW) has a similar diagnostic yield to NP sampling, but is cumbersome to perform. In this study, we introduce a 3D printed fluidic swab (3DPFS) that enables easy NW sampling for COVID-19 testing with improved diagnostic yield. The 3DPFS comprises a swab head, microchannel, and socket that can be connected to a syringe containing 250 \u00b5L of NW solution. The 3DPFS efficiently collects nasal fluid from the surface of the nasal cavity, resulting in higher sensitivity than CS for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This was confirmed by both reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and lateral flow assays (LFA) in virus-spiked nasal samples and clinical samples. Additionally, users reported greater comfort when using the 3DPFS compared to CS. These findings suggest that the 3DPFS can improve the performance of COVID-19 testing by facilitating efficient and less painful nasal sample collection.", "doi": "10.1186/s40580-023-00393-3", "pmid": "37715925", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10505115"}, {"db": "pii", "key": "10.1186/s40580-023-00393-3"}], "notes": [], "created": "2023-10-06T06:52:38.148Z", "modified": "2023-10-06T09:42:51.637Z"}, {"entity": "publication", "iuid": "3a6b1ba2f32c4f01b56d2579e63069f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a6b1ba2f32c4f01b56d2579e63069f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a6b1ba2f32c4f01b56d2579e63069f8"}}, "title": "The impact of reduced worry on general functioning: A mediation analysis from a randomized trial.", "authors": [{"family": "Andersson", "given": "Erik", "initials": "E", "orcid": "0000-0003-0088-8719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5bd630b521ea445ca28887ae1f5d20b4.json"}}, {"family": "Mataix-Cols", "given": "David", "initials": "D"}, {"family": "Lauri", "given": "Klara Olofsdotter", "initials": "KO"}, {"family": "de Schipper", "given": "Elles", "initials": "E"}, {"family": "Lj\u00f3tsson", "given": "Brj\u00e1nn", "initials": "B"}, {"family": "Aspvall", "given": "Kristina", "initials": "K"}, {"family": "Wahlund", "given": "Tove", "initials": "T"}], "type": "journal article", "published": "2023-09-14", "journal": {"title": "Stress Health", "issn": "1532-2998", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Previous lab findings have indicated that excessive worry may impair cognitive performance and problem solving capabilities but it is unclear if excessive worry also leads to broader impairments in general functioning. We report a secondary process data analysis of a large randomized waitlist-controlled trial (N = 670) of a self-guided online psychological intervention for dysfunctional worry related to the Covid-19 pandemic. Specific aims were to investigate (1) if improvements in general functioning were mediated by reductions in worry related to Covid-19 during the acute intervention phase, and (2) if reduced worry related to Covid-19 during acute intervention phase had a positive long-term impact on general functioning up to 1 year after the end of the intervention. To address aim 1, we used a mediation analysis framework where outcome (general functioning measured with an adapted version of the Work and Social Adjustment Scale) and the hypothesized mediator (worry measured with an adapted version of the Generalised Anxiety Disorder 7-Item Scale) were administered weekly during the controlled phase of the trial of 3 weeks. To address aim 2, we investigated if reductions in worry during the 3-week treatment period predicted improved general functioning at 1- and 12 months after treatment completion. Results showed that improvements in general functioning at week 3 were mediated by reductions in worry during the first 2 weeks of treatment (indirect effect estimate -0.08; 95% CI -0.15, -0.02). A sensitivity analysis indicated that the mediation effects dropped significantly when the residual correlation values between the mediator and the outcome exceeded r = 0. A reversed causation model was not significant. Additionally, reductions in worry during treatment predicted subsequent improvements in general functioning at both 1- and 12-month follow-ups (p < .05, -.001). Altogether, these results provide further support of the importance of targeting worry as a way to improve functioning among the large population of individuals with high levels of worry.", "doi": "10.1002/smi.3319", "pmid": "37706604", "labels": {"Type: Journal article": null, "Funder: Vinnova": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:56:31.383Z", "modified": "2023-10-06T11:18:41.186Z"}, {"entity": "publication", "iuid": "b2ea537b86cd48ad914e5398382be59f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b2ea537b86cd48ad914e5398382be59f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b2ea537b86cd48ad914e5398382be59f"}}, "title": "Temporal trends in hospitalizations and 30-day mortality in older patients during the COVID pandemic from March 2020 to July 2021.", "authors": [{"family": "Garcia-Ptacek", "given": "Sara", "initials": "S"}, {"family": "Xu", "given": "Hong", "initials": "H", "orcid": "0000-0002-7266-3431", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3aac746da836497ea13b648daac184b9.json"}}, {"family": "Annetorp", "given": "Martin", "initials": "M"}, {"family": "Jerlardtz", "given": "Viktoria B\u00e4ck", "initials": "VB"}, {"family": "Cederholm", "given": "Tommy", "initials": "T"}, {"family": "Engstr\u00f6m", "given": "Malin", "initials": "M"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Lundberg", "given": "Lars G\u00f6ran", "initials": "LG"}, {"family": "Metzner", "given": "Carina", "initials": "C"}, {"family": "Olsson", "given": "Maria", "initials": "M"}, {"family": "Nyvang", "given": "Josefina Skog\u00f6", "initials": "JS"}, {"family": "S\u00fchl \u00d6berg", "given": "Carina", "initials": "C"}, {"family": "\u00c5kesson", "given": "Elisabet", "initials": "E"}, {"family": "Religa", "given": "Dorota", "initials": "D"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2023-09-14", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "9", "pages": "e0291237"}, "abstract": "A reduction in mortality risk of COVID-19 throughout the first wave of the pandemic has been reported, but less is known about later waves. This study aimed to describe changes in hospitalizations and mortality of patients receiving inpatient geriatric care for COVID-19 or other causes during the pandemic.\r\n\r\nPatients 70 years and older hospitalized in geriatric hospitals in Stockholm for COVID-19 or other causes between March 2020-July 2021 were included. Data on the incidence of COVID-positive cases and 30-day mortality of the total \u2265 70-year-old population, in relation to weekly hospitalizations and mortality after hospital admissions were analyzed. Findings The total number of hospitalizations was 5,320 for COVID-19 and 32,243 for non-COVID-cases. In COVID-patients, the 30-day mortality rate was highest at the beginning of the first wave (29% in March-April 2020), reached 17% at the second wave peak (November-December) followed by 11-13% in the third wave (March-July 2021). The mortality in non-COVID geriatric patients showed a similar trend, but of lower magnitude (5-10%). During the incidence peaks, COVID-19 hospitalizations displaced non-COVID geriatric patients.\r\n\r\nHospital admissions and 30-day mortality after hospitalizations for COVID-19 increased in periods of high community transmission, albeit with decreasing mortality rates from wave 1 to 3, with a probable vaccination effect in wave 3. Thus, the healthcare system could not compensate for the high community spread of COVID-19 during the pandemic peaks, which also led to displacing care for non-COVID geriatric patients.", "doi": "10.1371/journal.pone.0291237", "pmid": "37708110", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10501674"}, {"db": "pii", "key": "PONE-D-22-12713"}], "notes": [], "created": "2023-09-18T16:00:46.524Z", "modified": "2023-10-06T09:58:21.706Z"}, {"entity": "publication", "iuid": "12ec45c4a43444138c0f4a53b788417a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/12ec45c4a43444138c0f4a53b788417a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/12ec45c4a43444138c0f4a53b788417a"}}, "title": "Symptoms, care consumption, and healthcare costs in hospitalized patients during the first wave of the COVID-19 pandemic.", "authors": [{"family": "Ashman Kr\u00f6\u00f6nstr\u00f6m", "given": "Linda", "initials": "L", "orcid": "0000-0002-4148-4844", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b0b88c35426e4eab9f7ee67e704cf5cf.json"}}, {"family": "Lundgren-Nilsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Kjellby-Wendt", "given": "Gunilla", "initials": "G"}, {"family": "Stibrant Sunnerhagen", "given": "Katharina", "initials": "K"}], "type": "observational study", "published": "2023-09-14", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "9", "pages": "e0291548"}, "abstract": "We aimed to assess symptomatology post discharge from the hospital in patients with COVID-19 treated during the first wave of the COVID-19 pandemic, and to follow care consumption and healthcare costs six months post discharge.\r\n\r\nThis study was a descriptive observational study over time. Data were retrieved from the Sahlgrenska University (SU) hospital registry for patients admitted to an SU hospital during March 2020 to August 2020. Of these, 1014 received a questionnaire approximately six weeks post discharge regarding symptoms. Data regarding care consumption were retrieved from the registry in the Region V\u00e4stra G\u00f6taland for 529 (52.2%) patients who completed the questionnaire. Of these, 466 patients were included in the analysis of care consumption.\r\n\r\nThere was a reported decrease in mobility from admission to discharge in both men (p = 0.02) and women (p = 0.01). The costs of inpatient care amounted to a total of 9 601 459.20 Euro (EUR). Symptoms were reported in 436 (93.6%) patients post discharge, of which weight loss during COVID-19 was most common in both men (n = 220, 77.5%) and women (n = 107, 58.8%). During six-month follow-up, 409 (87%) patients consumed care. Of the registered visits, 868 (27.1%) were related to a COVID-19 diagnosis. The total sum of outpatient care (i.e. visits with a registered COVID-19 diagnosis) was 77 311.30 EUR.\r\n\r\nAt discharge from the hospital, there was a decrease in mobility. Most patients had remaining sequelae post discharge. At six months post discharge, nearly 90% of patients had consumed care, with approximately 20% related to COVID-19. This indicates a persisting need for rehabilitation post discharge from hospital in patients treated for COVID-19.", "doi": "10.1371/journal.pone.0291548", "pmid": "37708157", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10501636"}, {"db": "pii", "key": "PONE-D-23-18622"}], "notes": [], "created": "2023-10-06T06:52:58.476Z", "modified": "2023-10-06T10:43:03.121Z"}, {"entity": "publication", "iuid": "ac117d7f4cd745d5903004c4a12e5fef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac117d7f4cd745d5903004c4a12e5fef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac117d7f4cd745d5903004c4a12e5fef"}}, "title": "SARS-CoV-2-related mortality decrease in nursing home residents given multiple COVID-19 boosters.", "authors": [{"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Fj\u00e4llstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Moln\u00e1r", "given": "Christian", "initials": "C"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Vikstr\u00f6m", "given": "Linnea", "initials": "L"}, {"family": "Wigren-Bystr\u00f6m", "given": "Julia", "initials": "J"}, {"family": "Bennet", "given": "Louise", "initials": "L"}, {"family": "Widerstr\u00f6m", "given": "Micael", "initials": "M"}, {"family": "Rasmussen", "given": "Gunl\u00f6g", "initials": "G"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}], "type": "letter", "published": "2023-09-13", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/S1473-3099(23)00548-0", "pmid": "37716359", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(23)00548-0"}], "notes": [], "created": "2023-09-18T15:57:53.001Z", "modified": "2023-09-18T15:58:15.616Z"}, {"entity": "publication", "iuid": "160e70d0a33f483e8aa20c2ea5a59fd2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/160e70d0a33f483e8aa20c2ea5a59fd2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/160e70d0a33f483e8aa20c2ea5a59fd2"}}, "title": "Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.", "authors": [{"family": "Mihali\u010d", "given": "Filip", "initials": "F", "orcid": "0000-0002-6840-2319", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9750b70b9a374be18d94abbc82fa5bbc.json"}}, {"family": "Benz", "given": "Caroline", "initials": "C", "orcid": "0000-0002-5166-3598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13332514bfe7460db4a0f134718aa211.json"}}, {"family": "Kassa", "given": "Eszter", "initials": "E"}, {"family": "Lindqvist", "given": "Richard", "initials": "R"}, {"family": "Simonetti", "given": "Leandro", "initials": "L", "orcid": "0000-0003-1283-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9ef81e96c104878a6ccea620fc95400.json"}}, {"family": "Inturi", "given": "Raviteja", "initials": "R"}, {"family": "Aronsson", "given": "Hanna", "initials": "H"}, {"family": "Andersson", "given": "Eva", "initials": "E"}, {"family": "Chi", "given": "Celestine N", "initials": "CN"}, {"family": "Davey", "given": "Norman E", "initials": "NE"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK", "orcid": "0000-0001-6553-0940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9024ab251cf44bffbf3229ec909343af.json"}}, {"family": "Jemth", "given": "Per", "initials": "P", "orcid": "0000-0003-1516-7228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c5fe566cf5f44df9c98bb2b1d7078ba.json"}}, {"family": "Ivarsson", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-7081-3846", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b3cf0504a1b476f906c4b3e22b05d5a.json"}}], "type": "journal article", "published": "2023-09-13", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "14", "issue": "1", "pages": "5636"}, "abstract": "The virus life cycle depends on host-virus protein-protein interactions, which often involve a disordered protein region binding to a folded protein domain. Here, we used proteomic peptide phage display (ProP-PD) to identify peptides from the intrinsically disordered regions of the human proteome that bind to folded protein domains encoded by the SARS-CoV-2 genome. Eleven folded domains of SARS-CoV-2 proteins were found to bind 281 peptides from human proteins, and affinities of 31 interactions involving eight SARS-CoV-2 protein domains were determined (KD \u223c 7-300 \u03bcM). Key specificity residues of the peptides were established for six of the interactions. Two of the peptides, binding Nsp9 and Nsp16, respectively, inhibited viral replication. Our findings demonstrate how high-throughput peptide binding screens simultaneously identify potential host-virus interactions and peptides with antiviral properties. Furthermore, the high number of low-affinity interactions suggest that overexpression of viral proteins during infection may perturb multiple cellular pathways.", "doi": "10.1038/s41467-023-41312-8", "pmid": "37704626", "labels": {"Type: Journal article": null, "Category: Proteins": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10499821"}, {"db": "pii", "key": "10.1038/s41467-023-41312-8"}], "notes": [], "created": "2023-09-18T15:51:27.180Z", "modified": "2023-10-06T11:29:41.684Z"}, {"entity": "publication", "iuid": "0fd16b7d2ef24af1b02e8409dd48f602", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0fd16b7d2ef24af1b02e8409dd48f602.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0fd16b7d2ef24af1b02e8409dd48f602"}}, "title": "Identification of essential genes associated with SARS-CoV-2 infection as potential drug target candidates with machine learning algorithms.", "authors": [{"family": "Taheri", "given": "Golnaz", "initials": "G"}, {"family": "Habibi", "given": "Mahnaz", "initials": "M"}], "type": "journal article", "published": "2023-09-13", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "15141"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires the fast discovery of effective treatments to fight this worldwide concern. Several genes associated with the SARS-CoV-2, which are essential for its functionality, pathogenesis, and survival, have been identified. These genes, which play crucial roles in SARS-CoV-2 infection, are considered potential therapeutic targets. Developing drugs against these essential genes to inhibit their regular functions could be a good approach for COVID-19 treatment. Artificial intelligence and machine learning methods provide powerful infrastructures for interpreting and understanding the available data and can assist in finding fast explanations and cures. We propose a method to highlight the essential genes that play crucial roles in SARS-CoV-2 pathogenesis. For this purpose, we define eleven informative topological and biological features for the biological and PPI networks constructed on gene sets that correspond to COVID-19. Then, we use three different unsupervised learning algorithms with different approaches to rank the important genes with respect to our defined informative features. Finally, we present a set of 18 important genes related to COVID-19. Materials and implementations are available at: https://github.com/MahnazHabibi/Gene_analysis .", "doi": "10.1038/s41598-023-42127-9", "pmid": "37704748", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Genomics & transcriptomics": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC10499814"}, {"db": "pii", "key": "10.1038/s41598-023-42127-9"}], "notes": [], "created": "2023-10-06T06:52:11.207Z", "modified": "2023-10-06T08:24:45.259Z"}, {"entity": "publication", "iuid": "ee8a417d0c014b54b315229da0a7672b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee8a417d0c014b54b315229da0a7672b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee8a417d0c014b54b315229da0a7672b"}}, "title": "Psychological distress and musculoskeletal pain in manual therapists during the second wave of the COVID-19 pandemic in Sweden: a cross-sectional study.", "authors": [{"family": "Weiss", "given": "Nathan", "initials": "N", "orcid": "0000-0002-1814-020X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd09b882d55a45d78c868e6fd116d660.json"}}, {"family": "Skillgate", "given": "Eva", "initials": "E"}, {"family": "Ax\u00e9n", "given": "Iben", "initials": "I"}], "type": "journal article", "published": "2023-09-12", "journal": {"title": "Chiropr Man Therap", "issn": "2045-709X", "issn-l": "2045-709X", "volume": "31", "issue": "1", "pages": "34"}, "abstract": "The COVID-19 pandemic had an unprecedented impact on healthcare, and the health of healthcare workers has been subject of much research. However, studies of health-related factors in manual therapists during the COVID-19 pandemic are scarce. Research in this field can provide valuable insights for future crises policy and guidelines, including in regions where the public health response to COVID-19 contrasts with that of most other international jurisdictions. The aim was to describe the prevalence of psychological distress and musculoskeletal pain, and to investigate factors potentially associated with high psychological distress and activity-limiting musculoskeletal pain in clinically active chiropractors and naprapaths during the second wave of the COVID-19 pandemic in Sweden.\r\n\r\nA cross-sectional survey was distributed to a representative sample of Swedish manual therapists, between November 2020 and January 2021. High psychological distress and activity-limiting musculoskeletal pain were investigated regarding associations with residing in a municipality with a high spread of infection, a previous/ongoing SARS-CoV-2 infection, clinical interferences and economic consequences associated with the pandemic. Generalized Linear Models with log link and binomial distribution were used, computing prevalence ratios (PR) with 95% confidence intervals (95% CI).\r\n\r\nA total of 762 participants were included, representing 46% of the source population. The prevalence of depressive, anxiety, and stress symptoms was 17%, 7%, and 12%, respectively. Neck (50%), low back (46%), upper back (40%), and shoulders (39%) were the most prevalent musculoskeletal pain areas. Economic consequences due to the pandemic were associated with high psychological distress (PR = 2.30, 95% CI: 1.48-3.53).\r\n\r\nDuring the second wave of the COVID-19 pandemic in Sweden, manual therapists primarily suffered from musculoskeletal pain related to the back and shoulders, while depressive symptoms were the most common symptom of psychological distress. Owners of businesses that suffered economic consequences had a higher prevalence of high psychological distress, which may call for targeted support of this group in future similar contexts. Future longitudinal studies during the pandemic are warranted to assess these associations further.", "doi": "10.1186/s12998-023-00511-2", "pmid": "37700309", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10498599"}, {"db": "pii", "key": "10.1186/s12998-023-00511-2"}], "notes": [], "created": "2023-10-06T06:52:30.019Z", "modified": "2023-10-06T09:41:12.833Z"}, {"entity": "publication", "iuid": "4e51eab6d2f54fce8ef5f19b576cf214", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4e51eab6d2f54fce8ef5f19b576cf214.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4e51eab6d2f54fce8ef5f19b576cf214"}}, "title": "Comparative effectiveness of mRNA-1273 and BNT162b2 COVID-19 vaccines in immunocompromised individuals: a systematic review and meta-analysis using the GRADE framework.", "authors": [{"family": "Wang", "given": "Xuan", "initials": "X"}, {"family": "Haeussler", "given": "Katrin", "initials": "K"}, {"family": "Spellman", "given": "Anne", "initials": "A"}, {"family": "Phillips", "given": "Leslie E", "initials": "LE"}, {"family": "Ramiller", "given": "Allison", "initials": "A"}, {"family": "Bausch-Jurken", "given": "Mary T", "initials": "MT"}, {"family": "Sharma", "given": "Pawana", "initials": "P"}, {"family": "Krivelyova", "given": "Anna", "initials": "A"}, {"family": "Vats", "given": "Sonam", "initials": "S"}, {"family": "Van de Velde", "given": "Nicolas", "initials": "N"}], "type": "meta-analysis", "published": "2023-09-12", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "1204831"}, "abstract": "Despite representing only 3% of the US population, immunocompromised (IC) individuals account for nearly half of the COVID-19 breakthrough hospitalizations. IC individuals generate a lower immune response after vaccination in general, and the US CDC recommended a third dose of either mRNA-1273 or BNT162b2 COVID-19 vaccines as part of their primary series. Influenza vaccine trials have shown that increasing dosage could improve effectiveness in IC populations. The objective of this systematic literature review and pairwise meta-analysis was to evaluate the clinical effectiveness of mRNA-1273 (50 or 100 mcg/dose) vs BNT162b2 (30 mcg/dose) in IC populations using the GRADE framework.\r\n\r\nThe systematic literature search was conducted in the World Health Organization COVID-19 Research Database. Studies were included in the pairwise meta-analysis if they reported comparisons of mRNA-1273 and BNT162b2 in IC individuals \u226518 years of age; outcomes of interest were symptomatic, laboratory-confirmed SARS-CoV-2 infection, SARS-CoV-2 infection, severe SARS-CoV-2 infection, hospitalization due to COVID-19, and mortality due to COVID-19. Risk ratios (RR) were pooled across studies using random-effects meta-analysis models. Outcomes were also analyzed in subgroups of patients with cancer, autoimmune disease, and solid organ transplant. Risk of bias was assessed using the Newcastle-Ottawa Scale for observational studies. Evidence was evaluated using the GRADE framework.\r\n\r\nOverall, 17 studies were included in the pairwise meta-analysis. Compared with BNT162b2, mRNA-1273 was associated with significantly reduced risk of SARS-CoV-2 infection (RR, 0.85 [95% CI, 0.75-0.97]; P=0.0151; I67.7%), severe SARS-CoV-2 infection (RR, 0.85 [95% CI, 0.77-0.93]; 2 = P=0.0009; I0%), COVID-19-associated hospitalization (RR, 0.88 [95% CI, 0.79-0.97]; 2 = P<0.0001; I0%), and COVID-19-associated mortality (RR, 0.63 [95% CI, 0.44-0.90]; 2 = P=0.0119; I0%) in IC populations. Results were consistent across subgroups. Because of sample size limitations, relative effectiveness of COVID-19 mRNA vaccines in IC populations cannot be studied in randomized trials. Based on nonrandomized studies, evidence certainty among comparisons was type 3 (low) and 4 (very low), reflecting potential biases in observational studies.2 =\r\n\r\nThis GRADE meta-analysis based on a large number of consistent observational studies showed that the mRNA-1273 COVID-19 vaccine is associated with improved clinical effectiveness in IC populations compared with BNT162b2.", "doi": "10.3389/fimmu.2023.1204831", "pmid": "37771594", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10523015"}], "notes": [], "created": "2023-10-06T06:52:18.225Z", "modified": "2023-10-06T08:46:46.071Z"}, {"entity": "publication", "iuid": "f707cac0c9ec4fc6b4115fc65fd5538d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f707cac0c9ec4fc6b4115fc65fd5538d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f707cac0c9ec4fc6b4115fc65fd5538d"}}, "title": "COVID-19 outcomes in patients with a history of immune-mediated glomerular diseases.", "authors": [{"family": "Gauckler", "given": "Philipp", "initials": "P"}, {"family": "Kesenheimer", "given": "Jana S", "initials": "JS"}, {"family": "Geetha", "given": "Duvuru", "initials": "D"}, {"family": "Odler", "given": "Balazs", "initials": "B"}, {"family": "Eller", "given": "Kathrin", "initials": "K"}, {"family": "Laboux", "given": "Timothee", "initials": "T"}, {"family": "Alberici", "given": "Federico", "initials": "F"}, {"family": "Zappa", "given": "Mattia", "initials": "M"}, {"family": "Chebotareva", "given": "Natasha", "initials": "N"}, {"family": "Moiseev", "given": "Sergey", "initials": "S"}, {"family": "Bonilla", "given": "Marco", "initials": "M"}, {"family": "Jhaveri", "given": "Kenar D", "initials": "KD"}, {"family": "Oniszczuk", "given": "Julie", "initials": "J"}, {"family": "Audard", "given": "Vincent", "initials": "V"}, {"family": "Costa", "given": "Denise", "initials": "D"}, {"family": "Mastroianni-Kirsztajn", "given": "Gianna", "initials": "G"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Muto", "given": "Masahiro", "initials": "M"}, {"family": "Windpessl", "given": "Martin", "initials": "M"}, {"family": "Mayer", "given": "Gert", "initials": "G"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2023-09-12", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "1228457"}, "abstract": "Patients with immune-mediated glomerular diseases are considered at high risk for severe COVID-19 outcomes. However, conclusive evidence for this patient population is scarce.\r\n\r\nWe created a global registry and retrospectively collected clinical data of patients with COVID-19 and a previously diagnosed immune-mediated glomerular disease to characterize specific risk factors for severe COVID-19 outcomes.\r\n\r\nFifty-nine patients with a history of immune-mediated glomerular diseases were diagnosed with COVID-19 between 01.03.2020 and 31.08.2021. Over a mean follow-up period of 24.79 \u00b1 18.89 days, ten patients (16.9%) developed acute kidney injury. Overall, 44.1% of patients were managed in an outpatient setting and therefore considered as having \"non-severe\" COVID-19, while 55.9% of patients had severe COVID-19 requiring hospitalization including worse outcomes. Comparing both groups, patients with severe COVID-19 were significantly older (53.55 \u00b1 17.91 versus 39.77 \u00b1 14.95 years, p = .003), had lower serum albumin levels at presentation (3.00 \u00b1 0.80 g/dL versus 3.99 \u00b1 0.68 g/dL, p = .016) and had a higher risk of developing acute kidney injury (27% versus 4%, p = .018). Male sex (p <.001) and ongoing intake of corticosteroids at presentation (p = .047) were also significantly associated with severe COVID-19 outcomes, while the overall use of ongoing immunosuppressive agents and glomerular disease remission status showed no significant association with the severity of COVID-19 (p = .430 and p = .326, respectively).\r\n\r\nOlder age, male sex, ongoing intake of corticosteroids and lower serum albumin levels at presentation were identified as risk factors for severe COVID-19 outcomes in patients with a history of various immune-mediated glomerular diseases.", "doi": "10.3389/fimmu.2023.1228457", "pmid": "37767096", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10520971"}], "notes": [], "created": "2023-10-06T06:55:31.187Z", "modified": "2023-10-06T10:56:25.611Z"}, {"entity": "publication", "iuid": "fde482edb3254b7aa40775042bfddfbf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fde482edb3254b7aa40775042bfddfbf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fde482edb3254b7aa40775042bfddfbf"}}, "title": "Type 1 diabetes, COVID-19 vaccines and short-term safety: Subgroup analysis from the global COVAD study.", "authors": [{"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Ravichandran", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Nair", "given": "Narmadha", "initials": "N"}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Barman", "given": "Bhupen", "initials": "B", "orcid": "0000-0002-5433-1310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7747785ec5fa4743bc70bd20fbca10fd.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Saha", "given": "Sreoshy", "initials": "S", "orcid": "0000-0001-6745-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00238845dd4833ae51ffb75e2fe144.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Pande", "given": "Arun Kumar R", "initials": "AKR", "orcid": "0000-0002-9570-1509", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ffc8a0aa37c14dffb457a50cd61740d5.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Boro", "given": "Hiya", "initials": "H"}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "COVAD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-09-11", "journal": {"title": "J Diabetes Investig", "issn": "2040-1124", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Coronavirus disease 2019 (COVID-19) vaccinations have been proven to be generally safe in healthy populations. However, the data on vaccine safety in patients with type 1 diabetes are scarce. This study aimed to evaluate the frequency and severity of short-term (<7-day) adverse vaccination events (AEs) and their risk factors among type 1 diabetes patients.\r\n\r\nThis study analyzed data from the COVID-19 vaccination in Autoimmune Diseases (COVAD) survey database (May to December 2021; 110 collaborators, 94 countries), comparing <7-day COVID-19 vaccine AE among type 1 diabetes patients and healthy controls (HCs). Descriptive statistics; propensity score matching (1:4) using the variables age, sex and ethnicity; and multivariate analyses were carried out.\r\n\r\nThis study analyzed 5,480 completed survey responses. Of all responses, 5,408 were HCs, 72 were type 1 diabetes patients (43 females, 48.0% white European ancestry) and Pfizer was the most administered vaccine (39%). A total of 4,052 (73.9%) respondents had received two vaccine doses. Patients with type 1 diabetes had a comparable risk of injection site pain, minor and major vaccine AEs, as well as associated hospitalizations to HCs. However, type 1 diabetes patients had a higher risk of severe rashes (3% vs 0.4%, OR 8.0, 95% confidence interval 1.7-36), P = 0.007), although reassuringly, these were rare (n = 2 among type 1 diabetes patients).\r\n\r\nCOVID-19 vaccination was safe and well tolerated in patients with type 1 diabetes with similar AE profiles compared with HCs, although severe rashes were more common in type 1 diabetes patients.", "doi": "10.1111/jdi.14079", "pmid": "37697820", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:56:49.199Z", "modified": "2023-10-06T11:30:56.100Z"}, {"entity": "publication", "iuid": "6eb4985c19994970802917859c7bf524", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6eb4985c19994970802917859c7bf524.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6eb4985c19994970802917859c7bf524"}}, "title": "Gambling helpline contacts during COVID-19-related availability restrictions: an interrupted time series analysis.", "authors": [{"family": "Wall", "given": "H", "initials": "H"}, {"family": "Kristiansen", "given": "S", "initials": "S"}, {"family": "Molander", "given": "O", "initials": "O"}, {"family": "Forsstr\u00f6m", "given": "D", "initials": "D"}, {"family": "Marionneau", "given": "V", "initials": "V"}], "type": "journal article", "published": "2023-09-09", "journal": {"title": "Public Health", "issn": "1476-5616", "issn-l": null, "volume": "224", "issue": null, "pages": "14-19"}, "abstract": "Gambling causes significant public health harms that are addressed in the help service network. Helplines are the most widely used service among those experiencing harms. The COVID-19 pandemic changed the global gambling landscape. This study assesses the effect of COVID-19-related restrictions on help-seeking for gambling via helplines.\r\n\r\nWe analysed data of national helplines in Sweden, Finland, and Denmark before and during the pandemic. The countries differed in their restrictions on the availability and accessibility of gambling during the pandemic.\r\n\r\nWe performed an interrupted time series analysis of contact and web traffic data to helplines in Sweden, Finland, and Denmark before and during the COVID-19 pandemic (2017-2021). We also compared forecasted time series to the actual data to assess change.\r\n\r\nThe results show diverging patterns across the three countries. In Sweden, the number of helpline contacts remained stable throughout COVID-19, but there was an increasing trend in website visits. In Finland, the number of contacts declined during the first wave but rebounded during the second wave. Website visitation increased moderately. In Denmark, the number of contacts to the helpline soared over the COVID-19 period.\r\n\r\nThe diverging results suggest that help-seeking behaviour is likely to be impacted by differing policy approaches to gambling availability and limit-setting, visibility of helplines, and the prevalence of different forms of gambling in the three Nordic countries before and during the pandemic. This has implications for a preventive public health approach for gambling.", "doi": "10.1016/j.puhe.2023.08.013", "pmid": "37696197", "labels": {"Type: Journal article": null, "Funder: Forte": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0033-3506(23)00296-2"}], "notes": [], "created": "2023-10-06T06:55:19.376Z", "modified": "2023-10-06T10:50:22.910Z"}, {"entity": "publication", "iuid": "3a916267a8004d29a0603ec71f47c07f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a916267a8004d29a0603ec71f47c07f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a916267a8004d29a0603ec71f47c07f"}}, "title": "Antibiotic prescriptions among dentists across Norway and the impact of COVID-19 pandemic.", "authors": [{"family": "Tousi", "given": "Farnoush", "initials": "F"}, {"family": "Al Haroni", "given": "Mohammed", "initials": "M"}, {"family": "Lie", "given": "Stein Atle", "initials": "SA"}, {"family": "Lund", "given": "Bodil", "initials": "B"}], "type": "journal article", "published": "2023-09-08", "journal": {"title": "BMC Oral Health", "issn": "1472-6831", "issn-l": null, "volume": "23", "issue": "1", "pages": "649"}, "abstract": "The prescription of antibiotics in dental practice contributes significantly to the total use of antibiotics in primary healthcare. This study aimed to evaluate antibiotic prescription in dental practice during the years 2016-2021 in Norway and their relative contribution to national outpatient consumption and to investigate the influence of age, gender, geographic region, and COVID-19. A further aim was to review differences in prescribing patterns to verify effect of governmental strategies to reduce over-prescribing of antibiotics.\r\n\r\nThis register study investigated the national antibiotic prescription between 2016 and 2021. Data was obtained from the Norwegian prescription register, the Norwegian Institute of Public Health and Statistics Norway. The consumption of 12 common antibiotics was measured using WHO defined daily doses (DDDs), DDD per 1000 inhabitants per day (DIDs 1000).\r\n\r\nA total of 6,049,445 antibiotic prescriptions of the 12 investigated compounds were issued in primary care during the study period. Dentists accounted for 942,350 prescriptions corresponding to 15.6% of the total. An overall decrease in the number of prescriptions by health professions other than dentists during the 5 years (IRR = 0.92, 95% CI:0.92-0.93, p < 0.001) was observed. For dentists a slight increase in the number of prescriptions (IRR = 1.01, 95% CI: 1.01-1.01, p < 0.001) was seen over the study period. The increase of antibiotic prescriptions in dentistry was more pronounced during the COVID-19 pandemic. The 4 most prescribed type of antibiotics based on average number of DDDs of the total period 2016-2021 were in descending order; phenoxymethylpenicillin (1,109,150) followed by amoxicillin (126,244), clindamycin (72,565), and metronidazole (64,599). An unexpected finding was that the prescription of the combination compound amoxicillin/clavulanic acid had significantly increased in dentistry during the last 5 years. Geographic, gender, and age differences in the rates of prescriptions were also seen. The data revealed that there are seasonal variations in dental prescriptions.\r\n\r\nNoticeable differences exist in prescribing patterns of antibiotics in the last 5 years. Restricted access to dental care due to COVID-19 may have resulted in increased antibiotic prescribing in dentistry as opposed to an otherwise downward trend. Despite national guidelines there is still a need for improvement of antibiotic stewardship in dentistry and to define effective methods to disseminate information.", "doi": "10.1186/s12903-023-03380-6", "pmid": "37684614", "labels": {"Category: Health": null, "Type: Journal article": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC10492408"}, {"db": "pii", "key": "10.1186/s12903-023-03380-6"}], "notes": [], "created": "2023-10-06T06:56:54.348Z", "modified": "2023-10-06T11:33:08.611Z"}, {"entity": "publication", "iuid": "c33bb0bd2b7a40c2a1086b25f36e79fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c33bb0bd2b7a40c2a1086b25f36e79fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c33bb0bd2b7a40c2a1086b25f36e79fd"}}, "title": "Perceptions of everyday life during lenient COVID-19 restrictions in Sweden- an interview study.", "authors": [{"family": "Lindgren", "given": "Ingrid", "initials": "I"}, {"family": "Trulsson Schouenborg", "given": "Anna", "initials": "A"}, {"family": "Larsson", "given": "Caroline", "initials": "C"}, {"family": "Stigmar", "given": "Kjerstin", "initials": "K"}], "type": "journal article", "published": "2023-09-07", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "23", "issue": "1", "pages": "1743"}, "abstract": "Both COVID-19 and its associated societal restrictions have affected individuals' health and everyday life. In Sweden, more lenient public health restrictions were implemented, with individuals asked to act responsibly in terms of reducing spread of disease. The majority of studies reporting on experiences of Covid-19 restrictions have been in the context of more substantial mandatory rules aimed at reducing social contact, therefore it is important to describe how more lenient restrictions have impacted individuals' well-being. This study aims to describe perceptions of everyday life during the first wave of the COVID-19 pandemic, perceived by individuals with no underlying medical condition, and living with more lenient public health restrictions in Sweden.\r\n\r\nThe participants were recruited from individuals who originally had participated in an online survey about life satisfaction, health, and physical activity. Fifteen individuals (median age 49, range 26-76 years, seven women) in various social situations, such as living alone/cohabiting, having children at home, geographical area and size of city were interviewed. Qualitative content analysis was applied to the data.\r\n\r\nAn overall theme \"Both hindrances and opportunities in important life domains were experienced within the same person during lenient Covid-19 restrictions\" was derived and covered three categories: \"New possibilities of flexibility in work and better health\", \"Life went on as usual with minor adjustments\" and \"Everyday life changed and became more difficult\" together with eight subcategories. For most participants, both facilitating and hindering important domains in life were described. Unexpected findings were positive experiences regarding working from home, physical activities, leisure time activities and the balance between work and leisure time. In areas where only minor adjustments were made, life was perceived as going on as before. On the other hand, restrictions increased worries and were perceived to have negative effects on social participation.\r\n\r\nThe impact of the pandemic and lenient restrictions in Sweden on the participants\u00b4 everyday life was multifaceted. Both hindrances and opportunities in important life domains were experienced within the same person. An increased flexibility in work- and leisure activities were perceived having positive effects for health and wellbeing and led to a better balance in life.", "doi": "10.1186/s12889-023-16599-3", "pmid": "37679662", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10483720"}, {"db": "pii", "key": "10.1186/s12889-023-16599-3"}], "notes": [], "created": "2023-10-06T06:56:17.554Z", "modified": "2023-10-06T11:15:12.699Z"}, {"entity": "publication", "iuid": "e4a3cefb49924dd39e8d1ba6dba2ed68", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e4a3cefb49924dd39e8d1ba6dba2ed68.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e4a3cefb49924dd39e8d1ba6dba2ed68"}}, "title": "COVID-19 pandemic hits differently: examining its consequences for women's livelihoods and healthcare access - a cross-sectional study in Kinshasa DRC.", "authors": [{"family": "Nkweleko Fankam", "given": "Falone", "initials": "F", "orcid": "0000-0001-7826-9382", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f15dd40fbc11449a8b1ab7fda57ae276.json"}}, {"family": "Ugarte", "given": "William", "initials": "W"}, {"family": "Akilimali", "given": "Pierre", "initials": "P"}, {"family": "Ewane Etah", "given": "Junior", "initials": "J"}, {"family": "\u00c5kerman", "given": "Eva", "initials": "E"}], "type": "journal article", "published": "2023-09-07", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "9", "pages": "e072869"}, "abstract": "The emergence of the COVID-19 pandemic led to multiple preventive actions as primary interventions to contain the spread of the virus. Globally, countries are facing enormous challenges with consequences for use of social, economic and health services. The Democratic Republic of Congo (DRC) was among the African countries implementing strict lockdown at the start of the pandemic, resulting in shortages and decreased access to services. The adverse effects of the pandemic had unpleasant consequences for the country. This study aimed to examine the association between COVID-19 pandemic-related factors, sociodemographic factors, and the need to visit healthcare facilities, including family planning services, among women aged 15-49 years in the DRC.\r\n\r\nWe conducted a secondary analysis of a performance monitoring for action (PMA) cross-sectional COVID-19 phone survey in Kinshasa, DRC, which had a response rate of 74.7%. In total, 1325 randomly selected women aged 15-49 years from the Kinshasa province who had previously participated in the PMA baseline survey participated in the survey. Bivariate and multivariate logistic regressions were used to assess associations.\r\n\r\nThe COVID-19 pandemic and related factors affected 92% of women in the Kinshasa province socioeconomically. A majority were highly economically dependent on their partner or some other sources for their basic needs to be met, and even more worried about the future impact of the pandemic on their household finances. Over 50% of women did not attempt visiting a health service, with some of the top reasons being fear of being infected with COVID-19 and not being able to afford services. We found a significant association between age groups and contraceptive use. The need for and use of contraceptives was higher among women aged 25-34 years than those aged 15-24 or 35-49 years.\r\n\r\nEffective social/economic support to women and girls during pandemics and in crises is essential as it can have lasting beneficial effects on many domains of their lives, including their ability to access health services and the contraceptives of their choice.", "doi": "10.1136/bmjopen-2023-072869", "pmid": "37678942", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10496687"}, {"db": "pii", "key": "bmjopen-2023-072869"}], "notes": [], "created": "2023-10-06T06:56:09.388Z", "modified": "2023-10-06T11:06:05.953Z"}, {"entity": "publication", "iuid": "6f160d0571b7441db235a4a6aa93b071", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f160d0571b7441db235a4a6aa93b071.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f160d0571b7441db235a4a6aa93b071"}}, "title": "Fresh or frozen grafts for allogeneic stem cell transplantation: conceptual considerations and a survey on the practice during the COVID-19 pandemic from the EBMT Infectious Diseases Working Party (IDWP) and Cellular Therapy & Immunobiology Working Party (CTIWP).", "authors": [{"family": "Worel", "given": "N", "initials": "N", "orcid": "0000-0002-3599-8099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0dc334f4e434fb7b018f43f56d9135c.json"}}, {"family": "Ljungman", "given": "P", "initials": "P", "orcid": "0000-0002-8281-3245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4546eb504184683ab712eee858ea9cb.json"}}, {"family": "Verheggen", "given": "I C M", "initials": "ICM"}, {"family": "Hoogenboom", "given": "J D", "initials": "JD"}, {"family": "Knelange", "given": "N S", "initials": "NS"}, {"family": "Eikema", "given": "D-J", "initials": "D"}, {"family": "S\u00e1nchez-Ortega", "given": "I", "initials": "I"}, {"family": "Riillo", "given": "C", "initials": "C"}, {"family": "Centorrino", "given": "I", "initials": "I"}, {"family": "Averbuch", "given": "D", "initials": "D", "orcid": "0000-0001-9614-7274", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/161ea7304f3046d1926a0b58ff122c98.json"}}, {"family": "Chabannon", "given": "C", "initials": "C", "orcid": "0000-0002-3755-4889", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6383ab718ee423da23a515b971751bc.json"}}, {"family": "de la Camara", "given": "R", "initials": "R", "orcid": "0000-0002-8189-5779", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/868bc0284ac640a1bf215e7d7cc86da3.json"}}, {"family": "Kuball", "given": "J", "initials": "J", "orcid": "0000-0002-3914-7806", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93b68b37f90949f681e03905510def84.json"}}, {"family": "Ruggeri", "given": "A", "initials": "A", "orcid": "0000-0002-7261-2765", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22584a74a4864481acc0ef4c17f12fc7.json"}}], "type": "journal article", "published": "2023-09-06", "journal": {"title": "Bone Marrow Transplant", "issn": "1476-5365", "issn-l": "0268-3369", "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic has had a significant impact on medical practices, including the delivery of allogeneic hematopoietic cell transplantation (HCT). In response, transplant centers have made changes to their procedures, including an increased use of cryopreservation for allogeneic haematopoietic progenitor cell (HPC) grafts. The use of cryopreserved grafts for allogeneic HCT has been reviewed and analysed in terms of potential benefits and drawbacks based on existing data on impact on cell subsets, hematological recovery, and clinical outcomes of approximately 2000 patients from different studies. A survey of European Society for Blood and Marrow Transplantation centers was also conducted to assess changes in practice during the pandemic and any unnecessary burdens on HPC donors. Before the pandemic, only 7.4% of transplant centers were routinely cryopreserving HPC products, but this percentage increased to 90% during the pandemic. The results of this review and survey suggest that cryopreservation of HPC grafts is a viable option for allogeneic HCT in certain situations, but further research is needed to determine long-term effects and ethical discussions are required to balance the needs of donors and patients when using frozen allografts.", "doi": "10.1038/s41409-023-02099-w", "pmid": "37673982", "labels": {"Type: Review": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41409-023-02099-w"}], "notes": [], "created": "2023-10-06T06:57:23.413Z", "modified": "2023-10-06T11:43:35.176Z"}, {"entity": "publication", "iuid": "46bc6c34a2ab4384b9c54c5e48b65926", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46bc6c34a2ab4384b9c54c5e48b65926.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46bc6c34a2ab4384b9c54c5e48b65926"}}, "title": "The Use of High-Flow Nasal Cannula and Non-Invasive Mechanical Ventilation in the Management of COVID-19 Patients: A Prospective Study.", "authors": [{"family": "Arunachala", "given": "Sumalatha", "initials": "S", "orcid": "0000-0001-5858-8298", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec761000c8c1429ba3459dcd08529abf.json"}}, {"family": "Parthasarathi", "given": "Ashwaghosha", "initials": "A", "orcid": "0000-0002-7270-0247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c0a5e6837a421cbbb0314628ae7f24.json"}}, {"family": "Basavaraj", "given": "Chetak Kadabasal", "initials": "CK", "orcid": "0000-0002-7422-8353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dea3044d43fb4b648b46945d7cb39367.json"}}, {"family": "Malamardi", "given": "Sowmya", "initials": "S"}, {"family": "Chandran", "given": "Shreya", "initials": "S"}, {"family": "Venkataraman", "given": "Hariharan", "initials": "H"}, {"family": "Ullah", "given": "Mohammed Kaleem", "initials": "MK", "orcid": "0000-0001-8470-3114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1645033dc8e84aa493a444301f0403ad.json"}}, {"family": "Ganguly", "given": "Koustav", "initials": "K", "orcid": "0000-0001-8531-8154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58b2e0d7853a4b32920e54042e95061d.json"}}, {"family": "Upadhyay", "given": "Swapna", "initials": "S", "orcid": "0000-0003-4699-4082", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c98621d4161241dd9379dca3fa6e1bf1.json"}}, {"family": "Mahesh", "given": "Padukudru Anand", "initials": "PA", "orcid": "0000-0003-1632-5945", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70c3b10ccc334c4c8195556f07c862d0.json"}}], "type": "journal article", "published": "2023-09-05", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "15", "issue": "9", "pages": null}, "abstract": "High-flow nasal cannula (HFNC) and ventilator-delivered non-invasive mechanical ventilation (NIV) were used to treat acute respiratory distress syndrome (ARDS) due to COVID-19 pneumonia, especially in low- and middle-income countries (LMICs), due to lack of ventilators and manpower resources despite the paucity of data regarding their efficacy. This prospective study aimed to analyse the efficacy of HFNC versus NIV in the management of COVID-19 ARDS. A total of 88 RT-PCR-confirmed COVID-19 patients with moderate ARDS were recruited. Linear regression and generalized estimating equations (GEEs) were used for trends in vital parameters over time. A total of 37 patients were on HFNC, and 51 were on NIV. Patients in the HFNC group stayed slightly but not significantly longer in the ICU as compared to their NIV counterparts (HFNC vs. NIV: 8.00 (4.0-12.0) days vs. 7.00 (2.0-12.0) days; p = 0.055). Intubation rates, complications, and mortality were similar in both groups. The switch to HFNC from NIV was 5.8%, while 37.8% required a switch to NIV from HFNC. The resolution of respiratory alkalosis was better with NIV. We conclude that in patients with COVID-19 pneumonia with moderate ARDS, the duration of treatment in the ICU, intubation rate, and mortality did not differ significantly with the use of HFNC or NIV for respiratory support.", "doi": "10.3390/v15091879", "pmid": "37766286", "labels": {"Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10535869"}, {"db": "pii", "key": "v15091879"}], "notes": [], "created": "2023-10-06T06:56:33.827Z", "modified": "2023-12-08T06:19:16.007Z"}, {"entity": "publication", "iuid": "db4ad85eac5d4bbe840da6bfb6a0e847", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db4ad85eac5d4bbe840da6bfb6a0e847.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db4ad85eac5d4bbe840da6bfb6a0e847"}}, "title": "Optimal age-specific vaccination control for COVID-19: An Irish case study.", "authors": [{"family": "Zavrakli", "given": "Eleni", "initials": "E", "orcid": "0000-0002-4866-5525", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d1bfa1f3bdd4c7a92e98d2abfe3a7d7.json"}}, {"family": "Parnell", "given": "Andrew", "initials": "A"}, {"family": "Malone", "given": "David", "initials": "D"}, {"family": "Duffy", "given": "Ken", "initials": "K"}, {"family": "Dey", "given": "Subhrakanti", "initials": "S"}], "type": "journal article", "published": "2023-09-05", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "9", "pages": "e0290974"}, "abstract": "The outbreak of a novel coronavirus causing severe acute respiratory syndrome in December 2019 has escalated into a worldwide pandemic. In this work, we propose a compartmental model to describe the dynamics of transmission of infection and use it to obtain the optimal vaccination control. The model accounts for the various stages of the vaccination, and the optimisation is focused on minimising the infections to protect the population and relieve the healthcare system. As a case study, we selected the Republic of Ireland. We use data provided by Ireland's COVID-19 Data-Hub and simulate the evolution of the pandemic with and without the vaccination in place for two different scenarios, one representative of a national lockdown situation and the other indicating looser restrictions in place. One of the main findings of our work is that the optimal approach would involve a vaccination programme where the older population is vaccinated in larger numbers earlier while simultaneously part of the younger population also gets vaccinated to lower the risk of transmission between groups. We compare our simulated results with those of the vaccination policy taken by the Irish government to explore the advantages of our optimisation method. Our comparison suggests that a similar reduction in cases may have been possible even with a reduced set of vaccinations available for use.", "doi": "10.1371/journal.pone.0290974", "pmid": "37669287", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Funder: H2020": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10479919"}, {"db": "pii", "key": "PONE-D-22-29430"}], "notes": [], "created": "2023-10-06T06:57:18.381Z", "modified": "2023-10-09T06:07:48.549Z"}, {"entity": "publication", "iuid": "563c15a9d6e84ace98f3e59d19dc6398", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/563c15a9d6e84ace98f3e59d19dc6398.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/563c15a9d6e84ace98f3e59d19dc6398"}}, "title": "Management of complications after skin surgery relevant for melanoma in the trunk and extremities during the COVID-19 pandemic: a case series report.", "authors": [{"family": "Huang", "given": "Yinglai", "initials": "Y"}, {"family": "Carlsson", "given": "Lena", "initials": "L"}, {"family": "Jogeland", "given": "Karin", "initials": "K"}, {"family": "Samuelsson", "given": "Marianne", "initials": "M"}, {"family": "Larsson", "given": "Lars", "initials": "L"}, {"family": "Jonsborg", "given": "Catarina", "initials": "C"}], "type": "case reports", "published": "2023-09-05", "journal": {"title": "World J Surg Oncol", "issn": "1477-7819", "issn-l": null, "volume": "21", "issue": "1", "pages": "280"}, "abstract": "Patients with melanoma have been found to be at greater risk of adverse outcomes including mortality after contacting COVID-19. Management of postsurgical complications presented additional challenges by potentially increasing exposure to COVID-19 through repeated inpatient admissions to hospital during the pandemic. We report four cases for which skin flaps, lymph ligation, and split-thickness skin graft (STSG) were successfully used in the treatment of complications in the trunk and extremities after wide local excision (WLE). This study details the operative experience in management of postsurgical complications for melanoma in the trunk and extremities during a 6-month period at the height of the COVID-19 pandemic.\r\n\r\nWe present 4 cases detailing management of complications that occurred after wide local excisions performed for melanoma during Feb. to Oct. 2020. Case 1: A 90-year-old man who experienced wound dehiscence and necrosis on the shoulder after non-radical excision for an aggressive melanoma and underwent the side-to-side closure after ellipse formed WLE with modified tangent-to-circle method. Case 2: An 80-year-old man who had undergone excision for melanoma in his left upper arm and histopathology did not show radically. Two weeks after the excision, he underwent a WLE and direct reconstruction with double rotation skin flap. Case 3: A 55-year-old man that experienced a large wound dehiscence on his back due to WLE. He underwent an advanced double skin flap operation. Case 4: A 36-year-old woman who had a lymphorrhea and graft necrosis after WLE and STSG on the right lower leg. A combination of micro lymph ligation and re-STSG was performed. One month after the operation, all wounds had healed. There was no clinical evidence of tumor recurrence after 8 months post procedure.\r\n\r\nSevere complications (e.g., large wound dehiscence, necrosis, or lymphorrhea) following wide local excision of melanoma are infrequent but must be swiftly and appropriately managed, especially during the COVID-19 pandemic to decrease the likelihood of COVID-19 infection and impaired oncology outcomes from delaying systemic cancer therapy due to the complications in primary interventions.", "doi": "10.1186/s12957-023-03084-9", "pmid": "37670317", "labels": {"Category: Health": null, "Category: Other": null, "Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10478401"}, {"db": "pii", "key": "10.1186/s12957-023-03084-9"}], "notes": [], "created": "2023-10-06T06:55:28.836Z", "modified": "2023-10-06T10:54:51.343Z"}, {"entity": "publication", "iuid": "968804a2c4004313b96cfa43ab3c7ea8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/968804a2c4004313b96cfa43ab3c7ea8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/968804a2c4004313b96cfa43ab3c7ea8"}}, "title": "End-of-life decision-making in critically ill old patients with and without coronavirus disease 2019.", "authors": [{"family": "Syrous", "given": "Alma Nordenskj\u00f6ld", "initials": "AN", "orcid": "0000-0002-8599-204X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e76d014cdc440b5ba8dc33aa7583db9.json"}}, {"family": "Gudnadottir", "given": "Gudny", "initials": "G"}, {"family": "Oras", "given": "Jonatan", "initials": "J", "orcid": "0000-0001-8890-6752", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bcac0f5ee544c18ba18e949ce76d121.json"}}, {"family": "Ferguson", "given": "Thalia", "initials": "T"}, {"family": "Lilja", "given": "David", "initials": "D"}, {"family": "Odenstedt Herges", "given": "Helena", "initials": "H", "orcid": "0000-0002-5146-0205", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10c52dc93bee4dd8b6dce4c7b8aa8237.json"}}, {"family": "Larsson", "given": "Emma", "initials": "E"}, {"family": "Block", "given": "Linda", "initials": "L", "orcid": "0000-0002-7736-0093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/829cb3512180455b874595d3f8f42730.json"}}], "type": "journal article", "published": "2023-09-05", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": null, "issue": null, "pages": null}, "abstract": "There are few studies on the differences in end-of-life decisions making in critically ill patients with and without coronavirus disease 2019 (COVID-19). This study aimed to investigate the independent factors that predicted the decision to withdraw or withhold life-sustaining treatments (LST) in critically ill patients and if these decisions were based on different variables for critically ill patients with COVID-19 compared to those for critically ill patients with other diagnoses in a Swedish intensive care unit.\r\n\r\nThis observational pilot study was performed at Sahlgrenska University Hospital, Gothenburg, Sweden. Patients \u226565 years were included from 1 March 2020 to 30 April 2021. The association between a decision to limit LST and a priori selected variables including sex, age, Simplified Acute Physiology Score 3 (SAPS 3), Clinical Frailty Scale \u22654, Charlson Comorbidity Index, Body Mass Index, living at home, invasive and non-invasive mechanical ventilation was assessed using a univariate and multivariable logistic regression model and presented as odds ratio with corresponding 95% confidence intervals.\r\n\r\nThere were 394 patients included in this study, 131 in the non-COVID-19 group and 263 in the COVID-19 group. For the non-COVID-19 cohort, the univariate analysis demonstrated that age and SAPS 3 were significantly associated with the decision to withdraw or withhold life-sustaining treatments, and this association remained in the multivariable analysis, with odds ratios of 1.10 (1.03-1.19) p = .009 and 1.06 (1.03-1.10) p < .001, respectively. For the COVID-19 cohort, the univariate analysis indicated that age, SAPS 3, and Charlson comorbidity index were significantly associated with the decision to withdraw or withhold life-sustaining treatments. However, in multivariable analysis, only the Charlson comorbidity index remained independently associated with the decision to withdraw or withhold life-sustaining treatments, with an odds ratio of 1.26 (1.07-1.49), p = .006.\r\n\r\nDecisions to withdraw or withhold life-sustaining treatments were based on other variables for the critically ill COVID-19 cohort compared to those for the critically ill non-COVID-19 cohort. Further studies are warranted to forge a common path for ethical end-of-life decision-making in critically ill patients.", "doi": "10.1111/aas.14326", "pmid": "37670491", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:55:09.867Z", "modified": "2023-10-06T10:45:20.324Z"}, {"entity": "publication", "iuid": "4ee3d80277934f77933848730ae1f433", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ee3d80277934f77933848730ae1f433.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ee3d80277934f77933848730ae1f433"}}, "title": "Correlates of breakthrough COVID-19 in vaccinated patients with systemic sclerosis: survival analysis from a multicentre international patient-reported survey.", "authors": [{"family": "Ahmed", "given": "Sakir", "initials": "S", "orcid": "0000-0003-4631-311X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd7df1f49c014c33b8ddaae05d8ac052.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Pauling", "given": "John D", "initials": "JD", "orcid": "0000-0002-2793-2364", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e37709273d404d17a88c7c850777b99f.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Ravichandran", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Jagtap", "given": "Kshitij", "initials": "K", "orcid": "0000-0003-2729-737X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822b9da98e5d4eb2975ff97fe484933f.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Saha", "given": "Sreoshy", "initials": "S", "orcid": "0000-0001-6745-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00238845dd4833ae51ffb75e2fe144.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Kardes", "given": "Sinan", "initials": "S", "orcid": "0000-0002-6311-8634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2900c3ca00da476a8914574384a3c9c2.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Wibowo", "given": "Suryo Anggoro Kusumo", "initials": "SAK"}, {"family": "COVAD Study Group", "given": "", "initials": ""}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}], "type": "journal article", "published": "2023-09-05", "journal": {"title": "Rheumatol Int", "issn": "1437-160X", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "This study aimed to assess the incidence, predictors, and outcomes of breakthrough infection (BI) following coronavirus disease (COVID-19) vaccination in patients with systemic sclerosis (SSc), a risk group associated with an immune-suppressed state and high cardiopulmonary disease burden. Cross-sectional data from fully vaccinated respondents with SSc, non-SSc autoimmune rheumatic diseases (AIRDs), and healthy controls (HCs) were extracted from the COVAD database, an international self-reported online survey. BI was defined according to the Centre for Disease Control definition. Infection-free survival was compared between the groups using Kaplan-Meier curves with log-rank tests. Cox proportional regression was used to assess the association between BI and age, sex, ethnicity, and immunosuppressive drugs at the time of vaccination. The severity of BI in terms of hospitalization and requirement for oxygen supplementation was compared between groups. Of 10,900 respondents, 6836 fulfilled the following inclusion criteria: 427 SSc, 2934 other AIRDs, and 3475 HCs. BI were reported in 6.3% of SSc, 6.9% of non-SSc AIRD, and 16.1% of HCs during a median follow-up of 100 (IQR: 60-137) days. SSc had a lower risk for BI than HC [hazard ratio (HR): 0.56 (95% CI 0.46-0.74)]. BIs were associated with age [HR: 0.98 (0.97-0.98)] but not ethnicity or immunosuppressive drugs at the time of vaccination. Patients with SSc were more likely to have asymptomatic COVID-19, but symptomatic patients reported more breathlessness. Hospitalization [SSc: 4 (14.8%), HCs: 37 (6.6%), non-SSc AIRDs: 32(15.8%)] and the need for oxygenation [SSc: 1 (25%); HC: 17 (45.9%); non-SSc AIRD: 13 (40.6%)] were similar between the groups. The incidence of BI in SSc was lower than that in HCs but comparable to that in non-SSc AIRDs. The severity of BI did not differ between the groups. Advancing age, but not ethnicity or immunosuppressive medication use, was associated with BIs.", "doi": "10.1007/s00296-023-05433-z", "pmid": "37668836", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00296-023-05433-z"}], "notes": [], "created": "2023-10-06T06:57:20.805Z", "modified": "2023-10-06T11:42:16.083Z"}, {"entity": "publication", "iuid": "7169dbc16bc04befabcac692ecef94df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7169dbc16bc04befabcac692ecef94df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7169dbc16bc04befabcac692ecef94df"}}, "title": "Post COVID-19 condition after SARS-CoV-2 infections during the omicron surge compared with the delta, alpha, and wild-type periods in Stockholm, Sweden.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P", "orcid": "0000-0003-3153-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd6af5accfc84ff9a81983a5ab6683aa.json"}}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2023-09-04", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899", "volume": null, "issue": null, "pages": null}, "abstract": "Little is known about post COVID-19 condition (PCC) after infections with different SARS-CoV-2 variants. We investigated the risk of PCC diagnosis after primary omicron infections compared with preceding variants in population-based cohorts in Stockholm, Sweden. Compared to omicron (n=215,279, 0.2% receiving a PCC diagnosis), the adjusted hazard ratio (95% confidence interval) was 3.26 (2.80 to 3.80) for delta (n=52,182, 0.5% PCC diagnosis), 5.33 (4.73 to 5.99) for alpha (n=97,978, 1.0% PCC diagnosis), and 6.31 (5.64 to 7.06) for wild-type (n=107,920, 1.3% PCC diagnosis). These findings were consistent across all subgroup analyses except among the ICU-treated.", "doi": "10.1093/infdis/jiad382", "pmid": "37665981", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Post-COVID": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "7259851"}], "notes": [], "created": "2023-10-06T06:52:43.737Z", "modified": "2023-10-06T09:54:10.819Z"}, {"entity": "publication", "iuid": "8452f5efb4e6418a9fef297f94232fce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8452f5efb4e6418a9fef297f94232fce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8452f5efb4e6418a9fef297f94232fce"}}, "title": "Oligomeric State of \u03b2-Coronavirus Non-Structural Protein 10 Stimulators Studied by Small Angle X-ray Scattering.", "authors": [{"family": "Knecht", "given": "Wolfgang", "initials": "W"}, {"family": "Fisher", "given": "S Zo\u00eb", "initials": "SZ"}, {"family": "Lou", "given": "Jiaqi", "initials": "J"}, {"family": "Sele", "given": "C\u00e9leste", "initials": "C"}, {"family": "Ma", "given": "Shumeng", "initials": "S"}, {"family": "Rasmussen", "given": "Anna Andersson", "initials": "AA"}, {"family": "Pinotsis", "given": "Nikos", "initials": "N"}, {"family": "Kozielski", "given": "Frank", "initials": "F", "orcid": "0000-0001-6096-9102", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8544f97e0f8841729c41626e742ec75f.json"}}], "type": "journal article", "published": "2023-09-04", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "issn-l": null, "volume": "24", "issue": "17", "pages": null}, "abstract": "The \u03b2-coronavirus family, encompassing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Severe Acute Respiratory Syndrome Coronavirus (SARS), and Middle East Respiratory Syndrome Coronavirus (MERS), has triggered pandemics within the last two decades. With the possibility of future pandemics, studying the coronavirus family members is necessary to improve knowledge and treatment. These viruses possess 16 non-structural proteins, many of which play crucial roles in viral replication and in other vital functions. One such vital protein is non-structural protein 10 (nsp10), acting as a pivotal stimulator of nsp14 and nsp16, thereby influencing RNA proofreading and viral RNA cap formation. Studying nsp10 of pathogenic coronaviruses is central to unraveling its multifunctional roles. Our study involves the biochemical and biophysical characterisation of full-length nsp10 from MERS, SARS and SARS-CoV-2. To elucidate their oligomeric state, we employed a combination of Multi-detection Size exclusion chromatography (Multi-detection SEC) with multi-angle static light scattering (MALS) and small angle X-ray scattering (SAXS) techniques. Our findings reveal that full-length nsp10s primarily exist as monomers in solution, while truncated versions tend to oligomerise. SAXS experiments reveal a globular shape for nsp10, a trait conserved in all three coronaviruses, although MERS nsp10, diverges most from SARS and SARS-CoV-2 nsp10s. In summary, unbound nsp10 proteins from SARS, MERS, and SARS-CoV-2 exhibit a globular and predominantly monomeric state in solution.", "doi": "10.3390/ijms241713649", "pmid": "37686452", "labels": {"Type: Journal article": null, "Category: Proteins": null, "Category: Imaging": null}, "xrefs": [{"db": "pii", "key": "ijms241713649"}], "notes": [], "created": "2023-10-06T06:57:03.206Z", "modified": "2023-10-06T11:34:06.712Z"}, {"entity": "publication", "iuid": "862c7810ef7a48d7b6334953b87bc98c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/862c7810ef7a48d7b6334953b87bc98c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/862c7810ef7a48d7b6334953b87bc98c"}}, "title": "Reducing intrusive memories after trauma via an imagery-competing task intervention in COVID-19 intensive care staff: a randomised controlled trial.", "authors": [{"family": "Iyadurai", "given": "Lalitha", "initials": "L"}, {"family": "Highfield", "given": "Julie", "initials": "J"}, {"family": "Kanstrup", "given": "Marie", "initials": "M", "orcid": "0000-0003-2060-5288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86830095163d4e14b62d78e8ed149b2e.json"}}, {"family": "Markham", "given": "Alfred", "initials": "A"}, {"family": "Ramineni", "given": "Varsha", "initials": "V", "orcid": "0000-0002-0330-3184", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9d359662cf044ac8308614e0f62f908.json"}}, {"family": "Guo", "given": "Boliang", "initials": "B"}, {"family": "Jaki", "given": "Thomas", "initials": "T"}, {"family": "Kingslake", "given": "Jonathan", "initials": "J", "orcid": "0000-0003-1741-1802", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d55190abd6f5468f8cb4f1890b0744fc.json"}}, {"family": "Goodwin", "given": "Guy M", "initials": "GM"}, {"family": "Summers", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-7269-2873", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd46e0acccc1403eae9148a5273f1a71.json"}}, {"family": "Bonsall", "given": "Michael B", "initials": "MB", "orcid": "0000-0003-0250-0423", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf8ee242158a4422ab7f8c00fb827150.json"}}, {"family": "Holmes", "given": "Emily A", "initials": "EA", "orcid": "0000-0001-7319-3112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be06518242494a02bd7cb6cf60a67541.json"}}], "type": "randomized controlled trial", "published": "2023-09-01", "journal": {"title": "Transl Psychiatry", "issn": "2158-3188", "issn-l": null, "volume": "13", "issue": "1", "pages": "290"}, "abstract": "Intrusive memories (IMs) after traumatic events can be distressing and disrupt mental health and functioning. We evaluated the impact of a brief remotely-delivered digital imagery-competing task intervention on the number of IMs for intensive care unit (ICU) staff who faced repeated trauma exposure during the COVID-19 pandemic using a two-arm, parallel-group, single-blind randomised controlled trial, with the comparator arm receiving delayed access to active treatment (crossover). Eligible participants worked clinically in a UK NHS ICU during the pandemic and had at least 3 IMs of work-related traumatic events in the week before recruitment. Participants were randomly assigned (1:1) to immediate (weeks 1-4) or delayed (weeks 5-8) intervention access. Sequential Bayesian analyses to optimise the intervention and increase trial efficiency are reported elsewhere [1]. The primary endpoint for the pre-specified frequentist analysis of the final study population compared the number of IMs experienced in week 4 between the immediate and delayed access arms. Secondary outcomes included clinical symptoms, work functioning and wellbeing. Safety was assessed throughout the trial by scheduled questions and free report. All analyses were undertaken on an intention-to-treat basis (86 randomised participants). There were significantly fewer intrusive memories during week 4 in the immediate (median = 1, IQR = 0-3, n = 43), compared to the comparator delayed arm (median = 10, IQR = 6-17, n = 43), IRR 0.31, 95% CI: 0.20-0.48, p < 0.001. After crossover, the delayed arm also showed a significant reduction in IMs at week 8 compared to week 4. There were convergent findings for symptoms of PTSD, insomnia and anxiety, work engagement and burnout, general functioning and quality of life. The intervention was found safe and acceptable to participants. All adverse events were unrelated to the study. Our study provides the first evidence of a benefit on reducing IMs, improving other clinical symptoms, work functioning and wellbeing, as well as safety of a brief remotely-delivered digital imagery-competing task intervention. An efficacy trial with an active control and longer follow-up is warranted. The trial is registered at ClinicalTrials.gov (NCT04992390).", "doi": "10.1038/s41398-023-02578-0", "pmid": "37658043", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10474101"}, {"db": "pii", "key": "10.1038/s41398-023-02578-0"}, {"db": "ClinicalTrials.gov", "key": "NCT04992390"}], "notes": [], "created": "2023-10-06T06:57:39.451Z", "modified": "2023-10-06T11:46:28.613Z"}, {"entity": "publication", "iuid": "8d698dc394ec4e62b585236343b3bc0f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d698dc394ec4e62b585236343b3bc0f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d698dc394ec4e62b585236343b3bc0f"}}, "title": "Radiological appearance and lung function six months after invasive ventilation in ICU for COVID-19 pneumonia: An observational follow-up study.", "authors": [{"family": "Konsberg", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-1542-5402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24e0c2f7ceaa45958a0a059f4e4f322d.json"}}, {"family": "Szaro", "given": "Pawel", "initials": "P"}, {"family": "Aneman", "given": "Anders", "initials": "A"}, {"family": "Kjellberg", "given": "Sanna", "initials": "S"}, {"family": "Solidakis", "given": "Nektarios", "initials": "N"}, {"family": "Svedlund", "given": "Sara", "initials": "S"}, {"family": "Nellg\u00e5rd", "given": "Bengt", "initials": "B"}, {"family": "Dalla", "given": "Keti", "initials": "K", "orcid": "0000-0001-7367-2500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f1c43bc04bf49a7adc3559aa5deb916.json"}}], "type": "observational study", "published": "2023-09-01", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "9", "pages": "e0289603"}, "abstract": "Respiratory functional sequelae in COVID-19 patients admitted to the intensive care unit for invasive ventilation are sparsely reported. The aim of this study was to investigate the radiological lung appearance, lung function and their association at 6 months after hospital discharge. It was hypothesized that the degree of pathological morphology on CT scans would correlate with lung function at the time of follow-up.\r\n\r\nIn this single-centre prospective observational study, 86 from 154 patients admitted to ICU due to COVID-19 between March 2020 and May 2021 were followed up at 6 months post discharge with computed tomography (CT) of the chest and pulmonary function tests (PFTs). The PFT results were expressed as z-scores calculated as the difference between the measured and predicted values divided by the standard deviation obtained from a reference population. Correlations were evaluated by Spearman's rho including the 95% confidence interval. Pathological changes on CT were found in 78/85 participants with fibrous parenchymal bands being the most prevalent finding (91%) followed by traction bronchiectasis (64%) and ground glass opacities (41%). Sixty-five participants performed PFTs, and a restrictive pattern was the most prevalent abnormality (34%). Diffusing capacity of the lung for carbon monoxide (DLCO) was reduced in 66% of participants. The CT severity score weakly correlated with forced vital capacity (FVC) z-score (0.295, p = 0.006), DLCO z-score (-0.231, p = 0.032) and alveolar volume (VA) z-score (0.253, p = 0.019).\r\n\r\nMost patients showed persistent radiological abnormalities on CT and reduced lung volumes, impaired diffusion capacity and patterns of restrictive lung function at 6 months post discharge from the ICU. The correlations between abnormalities on CT and lung function tests were weak. Further, studies with a long-term follow-up of lung function in this group of patients are needed.", "doi": "10.1371/journal.pone.0289603", "pmid": "37656699", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Imaging": null}, "xrefs": [{"db": "pmc", "key": "PMC10473523"}, {"db": "pii", "key": "PONE-D-22-31787"}], "notes": [], "created": "2023-10-06T06:57:08.003Z", "modified": "2023-10-06T11:37:14.743Z"}, {"entity": "publication", "iuid": "0fffeafdba3d43eaae8050e352b1b921", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0fffeafdba3d43eaae8050e352b1b921.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0fffeafdba3d43eaae8050e352b1b921"}}, "title": "Pentameric C-reactive protein is a better prognostic biomarker and remains elevated for longer than monomeric CRP in hospitalized patients with COVID-19.", "authors": [{"family": "Hopkins", "given": "Francis R", "initials": "FR"}, {"family": "Nordgren", "given": "Johan", "initials": "J"}, {"family": "Fernandez-Botran", "given": "Rafael", "initials": "R"}, {"family": "Enocsson", "given": "Helena", "initials": "H"}, {"family": "Govender", "given": "Melissa", "initials": "M"}, {"family": "Svanberg", "given": "Cecilia", "initials": "C"}, {"family": "Svensson", "given": "Lennart", "initials": "L"}, {"family": "Hagbom", "given": "Marie", "initials": "M"}, {"family": "Nilsdotter-Augustinsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Nystr\u00f6m", "given": "Sofia", "initials": "S"}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C"}, {"family": "Sj\u00f6wall", "given": "Johanna", "initials": "J"}, {"family": "Larsson", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2023-09-01", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "1259005"}, "abstract": "The differing roles of the pentameric (p) and monomeric (m) C-reactive protein (CRP) isoforms in viral diseases are not fully understood, which was apparent during the COVID-19 pandemic regarding the clinical course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Herein, we investigated the predictive value of the pCRP and mCRP isoforms for COVID-19 severity in hospitalized patients and evaluated how the levels of the protein isoforms changed over time during and after acute illness. This study utilized samples from a well-characterized cohort of Swedish patients with SARS-CoV-2 infection, the majority of whom had known risk factors for severe COVID-19 and required hospitalization. The levels of pCRP were significantly raised in patients with severe COVID-19 and in contrast to mCRP the levels were significantly associated with disease severity. Additionally, the pCRP levels remained elevated for at least six weeks post inclusion, which was longer compared to the two weeks for mCRP. Our data indicates a low level of inflammation lasting for at least six weeks following COVID-19, which might indicate that the disease has an adverse effect on the immune system even after the viral infection is resolved. It is also clear that the current standard method of testing pCRP levels upon hospitalization is a useful marker for predicting disease severity and mCRP testing would not add any clinical relevance for patients with COVID-19.", "doi": "10.3389/fimmu.2023.1259005", "pmid": "37724104", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Proteins": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10505432"}], "notes": [], "created": "2023-10-06T06:52:15.856Z", "modified": "2023-10-06T08:29:02.801Z"}, {"entity": "publication", "iuid": "d953102b4ac049d68c80a689db691673", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d953102b4ac049d68c80a689db691673.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d953102b4ac049d68c80a689db691673"}}, "title": "Occupational risks associated with severe COVID-19 disease and SARS-CoV-2 infection - a Swedish national case-control study conducted from October 2020 to December 2021.", "authors": [{"family": "Tor\u00e9n", "given": "Kjell", "initials": "K"}, {"family": "Albin", "given": "Maria", "initials": "M"}, {"family": "Bergstr\u00f6m", "given": "Tomas", "initials": "T"}, {"family": "Murgia", "given": "Nicola", "initials": "N"}, {"family": "Alderling", "given": "Magnus", "initials": "M"}, {"family": "Schi\u00f6ler", "given": "Linus", "initials": "L"}, {"family": "\u00c5berg", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2023-09-01", "journal": {"title": "Scand J Work Environ Health", "issn": "1795-990X", "issn-l": null, "volume": "49", "issue": "6", "pages": "386-394"}, "abstract": "This study aimed to investigate whether workplace factors and occupations are associated with SARS-CoV-2 infection or severe COVID-19 in the later waves of the pandemic.\r\n\r\nWe studied 552 562 cases with a positive test for SARS-CoV-2 in the Swedish registry of communicable diseases, and 5985 cases with severe COVID-19 based on hospital admissions from October 2020 to December 2021. Four population controls were assigned the index dates of their corresponding cases. We linked job histories to job-exposure matrices to assess the odds for different transmission dimensions and different occupations. We used adjusted conditional logistic analyses to estimate odds ratios (OR) for severe COVID-19 and SARS-CoV-2 with 95% confidence intervals (CI).\r\n\r\nThe highest OR for severe COVID-19 were for: regular contact with infected patients, (OR 1.37, 95% CI 1.23-1.54), close physical proximity (OR 1.47, 95% CI 1.34-1.61), and high exposure to diseases or infections (OR 1.72, 95% CI 1.52-1.96). Mostly working outside had lower OR (OR 0.77, 95% CI 0.57-1.06). The odds for SARS-CoV-2 when mostly working outside were similar (OR 0.83, 95% CI 0.80-0.86). The occupation with the highest OR for severe COVID-19 (compared with low-exposure occupations) was certified specialist physician (OR 2.05, 95% CI 1.31-3.21) among women and bus and tram drivers (OR 2.04, 95% CI 1.49-2.79) among men.\r\n\r\nContact with infected patients, close proximity and crowded workplaces increase the risks for severe COVID-19 and SARS-CoV-2 infection. Outdoor work is associated with decreased odds for SARS-CoV-2 infection and severe COVID-19.", "doi": "10.5271/sjweh.4103", "pmid": "37417898", "labels": {"Type: Journal article": null, "Funder: Forte": null, "Category: Other": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "4103"}], "notes": [], "created": "2023-10-04T12:07:32.911Z", "modified": "2023-10-04T12:16:58.601Z"}, {"entity": "publication", "iuid": "6cc1aecaf6a34214b4f33d84c367e7c2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6cc1aecaf6a34214b4f33d84c367e7c2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6cc1aecaf6a34214b4f33d84c367e7c2"}}, "title": "Trends in invasive bacterial diseases during the first 2 years of the COVID-19 pandemic: analyses of prospective surveillance data from 30 countries and territories in the IRIS Consortium.", "authors": [{"family": "Shaw", "given": "David", "initials": "D"}, {"family": "Abad", "given": "Raquel", "initials": "R"}, {"family": "Amin-Chowdhury", "given": "Zahin", "initials": "Z"}, {"family": "Bautista", "given": "Adriana", "initials": "A"}, {"family": "Bennett", "given": "Desiree", "initials": "D"}, {"family": "Broughton", "given": "Karen", "initials": "K"}, {"family": "Cao", "given": "Bin", "initials": "B"}, {"family": "Casanova", "given": "Carlo", "initials": "C"}, {"family": "Choi", "given": "Eun Hwa", "initials": "EH"}, {"family": "Chu", "given": "Yiu-Wai", "initials": "Y"}, {"family": "Claus", "given": "Heike", "initials": "H"}, {"family": "Coelho", "given": "Juliana", "initials": "J"}, {"family": "Corcoran", "given": "Mary", "initials": "M"}, {"family": "Cottrell", "given": "Simon", "initials": "S"}, {"family": "Cunney", "given": "Robert", "initials": "R"}, {"family": "Cuypers", "given": "Lize", "initials": "L"}, {"family": "Dalby", "given": "Tine", "initials": "T"}, {"family": "Davies", "given": "Heather", "initials": "H"}, {"family": "de Gouveia", "given": "Linda", "initials": "L"}, {"family": "Deghmane", "given": "Ala-Eddine", "initials": "A"}, {"family": "Demczuk", "given": "Walter", "initials": "W"}, {"family": "Desmet", "given": "Stefanie", "initials": "S"}, {"family": "Domenech", "given": "Mirian", "initials": "M"}, {"family": "Drew", "given": "Richard", "initials": "R"}, {"family": "du Plessis", "given": "Mignon", "initials": "M"}, {"family": "Duarte", "given": "Carolina", "initials": "C"}, {"family": "Erlendsd\u00f3ttir", "given": "Helga", "initials": "H"}, {"family": "Fry", "given": "Norman K", "initials": "NK"}, {"family": "Fuursted", "given": "Kurt", "initials": "K"}, {"family": "Hale", "given": "Thomas", "initials": "T"}, {"family": "Henares", "given": "Desiree", "initials": "D"}, {"family": "Henriques-Normark", "given": "Birgitta", "initials": "B"}, {"family": "Hilty", "given": "Markus", "initials": "M"}, {"family": "Hoffmann", "given": "Steen", "initials": "S"}, {"family": "Humphreys", "given": "Hilary", "initials": "H"}, {"family": "Ip", "given": "Margaret", "initials": "M"}, {"family": "Jacobsson", "given": "Susanne", "initials": "S"}, {"family": "Johnson", "given": "Christopher", "initials": "C"}, {"family": "Johnston", "given": "Jillian", "initials": "J"}, {"family": "Jolley", "given": "Keith A", "initials": "KA"}, {"family": "Kawabata", "given": "An\u00edbal", "initials": "A"}, {"family": "Kozakova", "given": "Jana", "initials": "J"}, {"family": "Kristinsson", "given": "Karl G", "initials": "KG"}, {"family": "Krizova", "given": "Pavla", "initials": "P"}, {"family": "Kuch", "given": "Alicja", "initials": "A"}, {"family": "Ladhani", "given": "Shamez", "initials": "S"}, {"family": "L\u00e2m", "given": "Thi\u00ean-Tr\u00ed", "initials": "T"}, {"family": "Le\u00f3n", "given": "Mar\u00eda Eugenia", "initials": "ME"}, {"family": "Lindholm", "given": "Laura", "initials": "L"}, {"family": "Litt", "given": "David", "initials": "D"}, {"family": "Maiden", "given": "Martin C J", "initials": "MCJ"}, {"family": "Martin", "given": "Irene", "initials": "I"}, {"family": "Martiny", "given": "Delphine", "initials": "D"}, {"family": "Mattheus", "given": "Wesley", "initials": "W"}, {"family": "McCarthy", "given": "Noel D", "initials": "ND"}, {"family": "Meehan", "given": "Mary", "initials": "M"}, {"family": "Meiring", "given": "Susan", "initials": "S"}, {"family": "M\u00f6lling", "given": "Paula", "initials": "P"}, {"family": "Morfeldt", "given": "Eva", "initials": "E"}, {"family": "Morgan", "given": "Julie", "initials": "J"}, {"family": "Mulhall", "given": "Robert", "initials": "R"}, {"family": "Mu\u00f1oz-Almagro", "given": "Carmen", "initials": "C"}, {"family": "Murdoch", "given": "David", "initials": "D"}, {"family": "Murphy", "given": "Joy", "initials": "J"}, {"family": "Musilek", "given": "Martin", "initials": "M"}, {"family": "Mzabi", "given": "Alexandre", "initials": "A"}, {"family": "Novakova", "given": "Ludmila", "initials": "L"}, {"family": "Oftadeh", "given": "Shahin", "initials": "S"}, {"family": "Perez-Arg\u00fcello", "given": "Amaresh", "initials": "A"}, {"family": "P\u00e9rez-V\u00e1zquez", "given": "Maria", "initials": "M"}, {"family": "Perrin", "given": "Monique", "initials": "M"}, {"family": "Perry", "given": "Malorie", "initials": "M"}, {"family": "Prevost", "given": "Benoit", "initials": "B"}, {"family": "Roberts", "given": "Maria", "initials": "M"}, {"family": "Rokney", "given": "Assaf", "initials": "A"}, {"family": "Ron", "given": "Merav", "initials": "M"}, {"family": "Sanabria", "given": "Olga Marina", "initials": "OM"}, {"family": "Scott", "given": "Kevin J", "initials": "KJ"}, {"family": "Sheppard", "given": "Carmen", "initials": "C"}, {"family": "Siira", "given": "Lotta", "initials": "L"}, {"family": "Sintchenko", "given": "Vitali", "initials": "V"}, {"family": "Skoczy\u0144ska", "given": "Anna", "initials": "A"}, {"family": "Sloan", "given": "Monica", "initials": "M"}, {"family": "Slotved", "given": "Hans-Christian", "initials": "H"}, {"family": "Smith", "given": "Andrew J", "initials": "AJ"}, {"family": "Steens", "given": "Anneke", "initials": "A"}, {"family": "Taha", "given": "Muhamed-Kheir", "initials": "M"}, {"family": "Toropainen", "given": "Maija", "initials": "M"}, {"family": "Tzanakaki", "given": "Georgina", "initials": "G"}, {"family": "Vainio", "given": "Anni", "initials": "A"}, {"family": "van der Linden", "given": "Mark P G", "initials": "MPG"}, {"family": "van Sorge", "given": "Nina M", "initials": "NM"}, {"family": "Varon", "given": "Emmanuelle", "initials": "E"}, {"family": "Vohrnova", "given": "Sandra", "initials": "S"}, {"family": "von Gottberg", "given": "Anne", "initials": "A"}, {"family": "Yuste", "given": "Jose", "initials": "J"}, {"family": "Zanella", "given": "Rosemeire", "initials": "R"}, {"family": "Zhou", "given": "Fei", "initials": "F"}, {"family": "Brueggemann", "given": "Angela B", "initials": "AB"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "The Lancet Digital Health", "issn": "2589-7500", "issn-l": null, "volume": "5", "issue": "9", "pages": "e582-e593"}, "abstract": "The Invasive Respiratory Infection Surveillance (IRIS) Consortium was established to assess the impact of the COVID-19 pandemic on invasive diseases caused by Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, and Streptococcus agalactiae. We aimed to analyse the incidence and distribution of these diseases during the first 2 years of the COVID-19 pandemic compared to the 2 years preceding the pandemic.\r\n\r\nFor this prospective analysis, laboratories in 30 countries and territories representing five continents submitted surveillance data from Jan 1, 2018, to Jan 2, 2022, to private projects within databases in PubMLST. The impact of COVID-19 containment measures on the overall number of cases was analysed, and changes in disease distributions by patient age and serotype or group were examined. Interrupted time-series analyses were done to quantify the impact of pandemic response measures and their relaxation on disease rates, and autoregressive integrated moving average models were used to estimate effect sizes and forecast counterfactual trends by hemisphere.\r\n\r\nOverall, 116 841 cases were analysed: 76 481 in 2018-19, before the pandemic, and 40 360 in 2020-21, during the pandemic. During the pandemic there was a significant reduction in the risk of disease caused by S pneumoniae (risk ratio 0\u00b747; 95% CI 0\u00b740-0\u00b755), H influenzae (0\u00b751; 0\u00b740-0\u00b766) and N meningitidis (0\u00b726; 0\u00b721-0\u00b731), while no significant changes were observed for S agalactiae (1\u00b702; 0\u00b775-1\u00b740), which is not transmitted via the respiratory route. No major changes in the distribution of cases were observed when stratified by patient age or serotype or group. An estimated 36 289 (95% prediction interval 17 145-55 434) cases of invasive bacterial disease were averted during the first 2 years of the pandemic among IRIS-participating countries and territories.\r\n\r\nCOVID-19 containment measures were associated with a sustained decrease in the incidence of invasive disease caused by S pneumoniae, H influenzae, and N meningitidis during the first 2 years of the pandemic, but cases began to increase in some countries towards the end of 2021 as pandemic restrictions were lifted. These IRIS data provide a better understanding of microbial transmission, will inform vaccine development and implementation, and can contribute to health-care service planning and provision of policies.\r\n\r\nWellcome Trust, NIHR Oxford Biomedical Research Centre, Spanish Ministry of Science and Innovation, Korea Disease Control and Prevention Agency, Torsten S\u00f6derberg Foundation, Stockholm County Council, Swedish Research Council, German Federal Ministry of Health, Robert Koch Institute, Pfizer, Merck, and the Greek National Public Health Organization.", "doi": "10.1016/S2589-7500(23)00108-5", "pmid": "37516557", "labels": {"Funder: VR": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2589-7500(23)00108-5"}], "notes": [], "created": "2023-10-04T12:10:31.535Z", "modified": "2023-10-04T13:15:07.482Z"}, {"entity": "publication", "iuid": "3b387324ed684abbae797117ddd0f81d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b387324ed684abbae797117ddd0f81d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b387324ed684abbae797117ddd0f81d"}}, "title": "The impact of the COVID-19 pandemic on children's learning and wellbeing: Evidence from India.", "authors": [{"family": "Guariso", "given": "Andrea", "initials": "A"}, {"family": "Bj\u00f6rkman Nyqvist", "given": "Martina", "initials": "M"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "J Dev Econ", "issn": "0304-3878", "issn-l": null, "volume": "164", "issue": null, "pages": "103133"}, "abstract": "We study the impact of the COVID-19 pandemic and associated school closure on primary school children's learning and mental wellbeing in Assam, India. Using a comprehensive dataset that tracked and repeatedly surveyed approximately 5000 children across 200 schools between 2018 and 2022, we find that children lost the equivalent of nine months of learning in mathematics and eleven months in language, during the pandemic. Children lacking resources and parental support experienced the largest losses. Regular practice, teacher interaction, and technology were associated with less learning loss. Over the same period, children's psychological wellbeing improved. Our research provides valuable insights for designing post-emergency programs.", "doi": "10.1016/j.jdeveco.2023.103133", "pmid": "37342545", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10264163"}, {"db": "pii", "key": "S0304-3878(23)00088-3"}], "notes": [], "created": "2023-10-04T09:32:19.037Z", "modified": "2023-10-04T11:01:58.570Z"}, {"entity": "publication", "iuid": "1c7f7c858ead4b93b04d424ae469e1fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1c7f7c858ead4b93b04d424ae469e1fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1c7f7c858ead4b93b04d424ae469e1fc"}}, "title": "Seasonal influence on respiratory tract infection severity including COVID-19 quantified through Markov Chain modeling.", "authors": [{"family": "van Wijk", "given": "Rob C", "initials": "RC", "orcid": "0000-0001-7247-1360", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aac8bd1a2d674d6c891c1a0becf997d8.json"}}, {"family": "Mockeliunas", "given": "Laurynas", "initials": "L", "orcid": "0000-0002-7008-4946", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f6959d9dd1f42a1abdd09bdf8d739f3.json"}}, {"family": "Upton", "given": "Caryn M", "initials": "CM"}, {"family": "Peter", "given": "Jonathan", "initials": "J"}, {"family": "Diacon", "given": "Andreas H", "initials": "AH"}, {"family": "Simonsson", "given": "Ulrika S H", "initials": "USH", "orcid": "0000-0002-3424-9686", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf510f552f2846b5bbb7740872a7c24a.json"}}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "CPT Pharmacometrics Syst. Pharmacol.", "issn": "2163-8306", "issn-l": null, "volume": "12", "issue": "9", "pages": "1250-1261"}, "abstract": "Respiratory tract infections (RTIs) are a burden to global health, but their characterization is complicated by the influence of seasonality on incidence and severity. The Re-BCG-CoV-19 trial (NCT04379336) assessed BCG (re)vaccination for protection from coronavirus disease 2019 (COVID-19) and recorded 958 RTIs in 574 individuals followed over 1 year. We characterized the probability of RTI occurrence and severity using a Markov model with health scores (HSs) for four states of symptom severity. Covariate analysis on the transition probability between HSs explored the influence of demographics, medical history, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), or influenza vaccinations, which became available during the trial, SARS-CoV-2 serology, and epidemiology-informed seasonal influence of infection pressure represented as regional COVID-19 pandemic waves, as well as BCG (re)vaccination. The infection pressure reflecting the pandemic waves increased the risk of RTI symptom development, whereas the presence of SARS-CoV-2 antibodies protected against RTI symptom development and increased the probability of symptom relief. Higher probability of symptom relief was also found in participants with African ethnicity and with male biological gender. SARS-CoV-2 or influenza vaccination reduced the probability of transitioning from mild to healthy symptoms. Model diagnostics over calendar-time indicated that COVID-19 cases were under-reported during the first wave by an estimated 2.76-fold. This trial was performed during the initial phase of the COVID-19 pandemic in South Africa and the results reflect that situation. Using this unique clinical dataset of prospectively studied RTIs over the course of 1 year, our Markov Chain model was able to capture risk factors for RTI development and severity, including epidemiology-informed infection pressure.", "doi": "10.1002/psp4.13006", "pmid": "37401774", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10508522"}, {"db": "ClinicalTrials.gov", "key": "NCT04379336"}], "notes": [], "created": "2023-10-04T12:07:40.665Z", "modified": "2023-10-04T12:22:15.271Z"}, {"entity": "publication", "iuid": "ed5ee9e208d34b9283c8973da3e782a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed5ee9e208d34b9283c8973da3e782a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed5ee9e208d34b9283c8973da3e782a1"}}, "title": "Operational challenges and mitigation measures during the COVID-19 pandemic-Lessons from DELIVER.", "authors": [{"family": "Bhatt", "given": "Ankeet S", "initials": "AS"}, {"family": "Lindholm", "given": "Daniel", "initials": "D"}, {"family": "Nilsson", "given": "Ann", "initials": "A"}, {"family": "Zaozerska", "given": "Natalia", "initials": "N"}, {"family": "Claggett", "given": "Brian L", "initials": "BL"}, {"family": "Vaduganathan", "given": "Muthiah", "initials": "M"}, {"family": "Kosiborod", "given": "Mikhail N", "initials": "MN"}, {"family": "Lam", "given": "Carolyn S P", "initials": "CSP"}, {"family": "Hernandez", "given": "Adrian F", "initials": "AF"}, {"family": "Martinez", "given": "Felipe A", "initials": "FA"}, {"family": "Inzucchi", "given": "Silvio E", "initials": "SE"}, {"family": "Shah", "given": "Sanjiv J", "initials": "SJ"}, {"family": "de Boer", "given": "Rudolf A", "initials": "RA"}, {"family": "Desai", "given": "Akshay", "initials": "A"}, {"family": "Jhund", "given": "Pardeep S", "initials": "PS"}, {"family": "Langkilde", "given": "Anna Maria", "initials": "AM"}, {"family": "Petersson", "given": "Magnus", "initials": "M"}, {"family": "McMurray", "given": "John J V", "initials": "JJV"}, {"family": "Solomon", "given": "Scott D", "initials": "SD"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Am Heart J", "issn": "1097-6744", "issn-l": null, "volume": "263", "issue": null, "pages": "133-140"}, "abstract": "Catastrophic disruptions in care delivery threaten the operational efficiency and potentially the validity of clinical research efforts, in particular randomized clinical trials. Most recently, the COVID-19 pandemic affected essentially all aspects of care delivery and clinical research conduct. While consensus statements and clinical guidance documents have detailed potential mitigation measures, few real-world experiences detailing clinical trial adaptations to the COVID-19 pandemic exist, particularly among, large, global registrational cardiovascular trials.\r\n\r\nWe outline the operational impact of COVID-19 and resultant mitigation measures in the Dapagliflozin Evaluation to Improve the LIVEs of Patients with Preserved Ejection Fraction Heart Failure (DELIVER) trial, one of the largest and most globally diverse experiences with COVID-19 of any cardiovascular clinical trial to date. Specifically, we address the needed coordination between academic investigators, trial leadership, clinical sites, and the supporting sponsor to ensure the safety of participants and trial staff, to maintain the fidelity of trial operations, and to prospectively adapt statistical analyses plans to evaluate the impact of COVID-19 and the pandemic at large on trial participants. These discussions included key operational issues such as ensuring delivery of study medications, adaptations to study visits, enhanced COVID-19 related endpoint adjudication, and protocol and analytical plan revisions.\r\n\r\nOur findings may have important implications for establishing consensus on prospective contingency planning in future clinical trials.\r\n\r\ngov: NCT03619213.\r\n\r\nGOV: NCT03619213.", "doi": "10.1016/j.ahj.2023.05.013", "pmid": "37220822", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10200275"}, {"db": "pii", "key": "S0002-8703(23)00132-1"}, {"db": "ClinicalTrials.gov", "key": "NCT03619213"}], "notes": [], "created": "2023-10-04T05:10:17.305Z", "modified": "2023-10-04T06:33:48.984Z"}, {"entity": "publication", "iuid": "cde59eddc81548a1abc15d6ffe2a194a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cde59eddc81548a1abc15d6ffe2a194a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cde59eddc81548a1abc15d6ffe2a194a"}}, "title": "Multiple manifestations of uncontrolled asthma increase the risk of severe COVID-19.", "authors": [{"family": "Selberg", "given": "Stina", "initials": "S"}, {"family": "Karlsson Sundbaum", "given": "Johanna", "initials": "J"}, {"family": "Konradsen", "given": "Jon R", "initials": "JR"}, {"family": "Backman", "given": "Helena", "initials": "H"}, {"family": "Hedman", "given": "Linnea", "initials": "L"}, {"family": "Lindberg", "given": "Anne", "initials": "A"}, {"family": "Stridsman", "given": "Caroline", "initials": "C"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Respir Med", "issn": "1532-3064", "issn-l": "0954-6111", "volume": "216", "issue": null, "pages": "107308"}, "abstract": "Asthma control is of importance when assessing the risk of severe outcomes of COVID-19. The aim of this study was to explore associations of clinical characteristics and the effect of multiple manifestations of uncontrolled asthma with severe COVID-19.\r\n\r\nIn 2014-2020, adult patients with uncontrolled asthma, defined as Asthma Control Test (ACT) \u226419 were identified in the Swedish National Airway Register (SNAR) (n = 24533). The SNAR database, including clinical data, was linked with national registers to identify patients with severe COVID-19 (n = 221). The effect of multiple manifestations of uncontrolled asthma was based on: 1) ACT \u226415, 2) frequent exacerbations and 3) previous asthma inpatient/secondary care and evaluated stepwise. Poisson regression analyses were conducted with severe COVID-19 as the dependent variable.\r\n\r\nIn this cohort with uncontrolled asthma, obesity was the strongest independent risk factor for severe COVID-19 in both sexes, but even greater in men. Multiple manifestations of uncontrolled asthma were more common among those with severe COVID-19 vs. without: one, 45.7 vs. 42.3%, two, 18.1 vs. 9.1% and three, 5.0 vs. 2.1%. The risk ratio (RR) of severe COVID-19 increased with an increasing number of manifestations of uncontrolled asthma: one, RR 1.49 (95% CI 1.09-2.02), two, RR 2.42 (95% CI 1.64-3.57) and three, RR 2.96 (95% CI 1.57-5.60), when adjusted for sex, age, and BMI.\r\n\r\nIt is important to consider the effect of multiple manifestations of uncontrolled asthma and obesity when assessing patients with COVID-19, as this increases the risk of severe outcomes substantially.", "doi": "10.1016/j.rmed.2023.107308", "pmid": "37271301", "labels": {"Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10238115"}, {"db": "pii", "key": "S0954-6111(23)00196-8"}], "notes": [], "created": "2023-10-04T09:30:31.135Z", "modified": "2023-10-04T09:57:30.750Z"}, {"entity": "publication", "iuid": "a39c2ff1e6d94a1f951e4c3f635d65f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a39c2ff1e6d94a1f951e4c3f635d65f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a39c2ff1e6d94a1f951e4c3f635d65f0"}}, "title": "Long-term safety of COVID vaccination in individuals with idiopathic inflammatory myopathies: results from the COVAD study.", "authors": [{"family": "Doskaliuk", "given": "Bohdana", "initials": "B", "orcid": "0000-0003-1650-8928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5c55895beec4f5fa9fe0545f38b72d1.json"}}, {"family": "Ravichandran", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Saha", "given": "Sreoshy", "initials": "S", "orcid": "0000-0001-6745-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00238845dd4833ae51ffb75e2fe144.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Jagtap", "given": "Kshitij", "initials": "K", "orcid": "0000-0003-2729-737X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822b9da98e5d4eb2975ff97fe484933f.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Chen", "given": "Yi Ming", "initials": "YM", "orcid": "0000-0001-7593-3065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/795f1bf1d4824521a3301f7c50f62bc4.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Patel", "given": "Aarat", "initials": "A"}, {"family": "Pauling", "given": "John D", "initials": "JD", "orcid": "0000-0002-2793-2364", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e37709273d404d17a88c7c850777b99f.json"}}, {"family": "Wincup", "given": "Chris", "initials": "C", "orcid": "0000-0002-8742-8311", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a674f02e7f7f45f58167eb24f81502f3.json"}}, {"family": "Barman", "given": "Bhupen", "initials": "B", "orcid": "0000-0002-5433-1310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7747785ec5fa4743bc70bd20fbca10fd.json"}}, {"family": "Tehozol", "given": "Erick Adrian Zamora", "initials": "EAZ", "orcid": "0000-0002-7888-3961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a55c695ac4f4003993a2f511cca7739.json"}}, {"family": "Serrano", "given": "Jorge Rojas", "initials": "JR", "orcid": "0000-0001-6980-7898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/225fd8b396ac40f4a77f1ec229c086b6.json"}}, {"family": "La Torre", "given": "Ignacio Garc\u00eda-De", "initials": "IG", "orcid": "0000-0002-9261-678X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/086b85d66fb84b50bd51bbe5a979dfe3.json"}}, {"family": "Colunga-Pedraza", "given": "Iris J", "initials": "IJ", "orcid": "0000-0002-2786-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50e46ef2c7f44b39a1d28fea6a8e621d.json"}}, {"family": "Merayo-Chalico", "given": "Javier", "initials": "J", "orcid": "0000-0002-5870-0523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d74c0ab33cbe4df586e1a1add37d0e65.json"}}, {"family": "Chibuzo", "given": "Okwara Celestine", "initials": "OC", "orcid": "0000-0002-7727-5657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f415c3f3dea49cb90ae12def4278f00.json"}}, {"family": "Katchamart", "given": "Wanruchada", "initials": "W", "orcid": "0000-0002-8952-5967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9439933b38fb49aca8fdbb5038ff603c.json"}}, {"family": "Goo", "given": "Phonpen Akarawatcharangura", "initials": "PA", "orcid": "0009-0009-7611-9992", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3979fce5848e46d2af71814d96ad0406.json"}}, {"family": "Shumnalieva", "given": "Russka", "initials": "R", "orcid": "0000-0003-2321-6536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/933232cd7feb48ee81b5971f01f52e23.json"}}, {"family": "Hoff", "given": "Leonardo Santos", "initials": "LS", "orcid": "0000-0002-2083-4796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1df7af8caf024ca39c57278fdf18c766.json"}}, {"family": "Kibbi", "given": "Lina El", "initials": "LE", "orcid": "0000-0003-1710-9996", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11bb4fc524264c6897dec9642a0ef7cd.json"}}, {"family": "Halabi", "given": "Hussein", "initials": "H", "orcid": "0000-0002-5174-8292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb337090a5ab4461a07e8620bee1b4b9.json"}}, {"family": "Vaidya", "given": "Binit", "initials": "B", "orcid": "0000-0002-4840-8924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b2296d53fe14fc7a8415f26e03e1944.json"}}, {"family": "Shaharir", "given": "Syahrul Sazliyana", "initials": "SS", "orcid": "0000-0002-9068-8114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1e6310979d44d58b548c61c733412af.json"}}, {"family": "Hasan", "given": "A T M Tanveer", "initials": "ATMT", "orcid": "0000-0002-5332-3319", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ffdb3329292438fac4005923ee79012.json"}}, {"family": "Dey", "given": "Dzifa", "initials": "D", "orcid": "0000-0002-3339-5112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2615e43aeba34a0585679bdd14a1a324.json"}}, {"family": "Guti\u00e9rrez", "given": "Carlos Enrique Toro", "initials": "CET", "orcid": "0000-0002-6084-7049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/980e455c5d114caaaefb6e0b55eaa3b3.json"}}, {"family": "Caballero-Uribe", "given": "Carlo V", "initials": "CV", "orcid": "0000-0002-9845-8620", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42d86c9923424f9a804bab4580b993c3.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "COVAD study group", "given": "", "initials": ""}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Rheumatol Int", "issn": "1437-160X", "issn-l": null, "volume": "43", "issue": "9", "pages": "1651-1664"}, "abstract": "Limited evidence on long-term COVID-19 vaccine safety in patients with idiopathic inflammatory myopathies (IIMs) continues to contribute to vaccine hesitancy. We studied delayed-onset vaccine adverse events (AEs) in patients with IIMs, other systemic autoimmune and inflammatory disorders (SAIDs), and healthy controls (HCs), using data from the second COVID-19 Vaccination in Autoimmune Diseases (COVAD) study. A validated self-reporting e-survey was circulated by the COVAD study group (157 collaborators, 106 countries) from Feb-June 2022. We collected data on demographics, comorbidities, IIM/SAID details, COVID-19 history, and vaccination details. Delayed-onset (> 7 day) AEs were analyzed using regression models. A total of 15165 respondents undertook the survey, of whom 8759 responses from vaccinated individuals [median age 46 (35-58) years, 74.4% females, 45.4% Caucasians] were analyzed. Of these, 1390 (15.9%) had IIMs, 50.6% other SAIDs, and 33.5% HCs. Among IIMs, 16.3% and 10.2% patients reported minor and major AEs, respectively, and 0.72% (n = 10) required hospitalization. Notably patients with IIMs experienced fewer minor AEs than other SAIDs, though rashes were expectedly more than HCs [OR 4.0; 95% CI 2.2-7.0, p < 0.001]. IIM patients with active disease, overlap myositis, autoimmune comorbidities, and ChadOx1 nCOV-19 (Oxford/AstraZeneca) recipients reported AEs more often, while those with inclusion body myositis, and BNT162b2 (Pfizer) recipients reported fewer AEs. Vaccination is reassuringly safe in individuals with IIMs, with AEs, hospitalizations comparable to SAIDs, and largely limited to those with autoimmune multimorbidity and active disease. These observations may inform guidelines to identify high-risk patients warranting close monitoring in the post-vaccination period.", "doi": "10.1007/s00296-023-05345-y", "pmid": "37351634", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10348925"}, {"db": "pii", "key": "10.1007/s00296-023-05345-y"}], "notes": [], "created": "2023-10-04T09:32:26.527Z", "modified": "2023-10-04T11:07:53.247Z"}, {"entity": "publication", "iuid": "29b8c3b876cf42b588d620c08f0cd89f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/29b8c3b876cf42b588d620c08f0cd89f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/29b8c3b876cf42b588d620c08f0cd89f"}}, "title": "Immune responses to SARS-CoV-2 infection and vaccination in children.", "authors": [{"family": "Brodin", "given": "Petter", "initials": "P"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Semin Immunol", "issn": "1096-3618", "issn-l": null, "volume": "69", "issue": null, "pages": "101794"}, "abstract": "During the three years since SARS-CoV-2 infections were first described a wealth of information has been gathered about viral variants and their changing properties, the disease presentations they elicit and how the many vaccines developed in record time protect from COVID-19 severe disease in different populations. A general theme throughout the pandemic has been the observation that children and young people in general fare well, with mild symptoms during acute infection and full recovery thereafter. It has also become clear that this is not universally true, as some children develop severe COVID-19 hypoxic pneumonia and even succumb to the infection, while another group of children develop a rare but serious multisystem inflammatory syndrome (MIS-C) and some other children experience prolonged illness following acute infection, post-COVID. Here I will discuss some of the findings made to explain these diverse disease manifestations in children and young people infected by SARS-CoV-2. I will also discuss the vaccines developed at record speed and their efficacy in protecting children from disease.", "doi": "10.1016/j.smim.2023.101794", "pmid": "37536147", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null, "Category: Vaccines": null, "Funder: H2020": null}, "xrefs": [{"db": "pmc", "key": "PMC10281229"}, {"db": "pii", "key": "S1044-5323(23)00085-4"}], "notes": [], "created": "2023-10-05T08:01:56.621Z", "modified": "2023-10-05T08:38:56.090Z"}, {"entity": "publication", "iuid": "0b24a4a644084329838bcebf6a5eb49b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b24a4a644084329838bcebf6a5eb49b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b24a4a644084329838bcebf6a5eb49b"}}, "title": "ISTH guidelines for antithrombotic treatment in COVID-19: Endorsement by the Scandinavian Society of Anaesthesiology and Intensive Care Medicine.", "authors": [{"family": "Chew", "given": "Michelle S", "initials": "MS", "orcid": "0000-0003-2888-4111", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c68391bb66e94be1ac0a14d69430666e.json"}}, {"family": "Olkkola", "given": "Klaus T", "initials": "KT"}, {"family": "Kalliom\u00e4ki", "given": "Maija-Liisa", "initials": "M"}, {"family": "Rehn", "given": "Marius", "initials": "M"}, {"family": "Sigur\u00f0sson", "given": "Martin Ingi", "initials": "MI"}, {"family": "M\u00f8ller", "given": "Morten Hylander", "initials": "MH", "orcid": "0000-0002-6378-9673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1cf88aaa5c9436a8e70ddfe39cfe4e8.json"}}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": "67", "issue": "8", "pages": "1118-1120"}, "abstract": "The Clinical Practice Committee of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine endorses the ISTH guidelines for antithrombotic treatment in COVID-19. This evidence-based guideline serves as a useful decision aid for Nordic anaesthesiologists caring for patients with COVID-19.", "doi": "10.1111/aas.14259", "pmid": "37318942", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:31:21.293Z", "modified": "2023-10-04T10:49:25.736Z"}, {"entity": "publication", "iuid": "e6045f02c1c24528984fafc7101ed0d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6045f02c1c24528984fafc7101ed0d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6045f02c1c24528984fafc7101ed0d0"}}, "title": "Home care nurses' and managers' work environment during the Covid-19 pandemic: Increased workload, competing demands, and unsustainable trade-offs.", "authors": [{"family": "Rydenf\u00e4lt", "given": "Christofer", "initials": "C"}, {"family": "Persson", "given": "Johanna", "initials": "J"}, {"family": "Erlingsd\u00f3ttir", "given": "Gudbj\u00f6rg", "initials": "G"}, {"family": "Larsson", "given": "Roger", "initials": "R"}, {"family": "Johansson", "given": "Gerd", "initials": "G"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Appl Ergon", "issn": "1872-9126", "issn-l": null, "volume": "111", "issue": null, "pages": "104056"}, "abstract": "Little research exists on how home care nursing personnel have experienced the Covid-19 pandemic. This qualitative study explores the work environment related challenges nurses and managers in home care faced during the pandemic. We discuss these challenges in relation to the Demand-Control-Support Model and reflect on how the organizational dynamics associated with them can be understood using the competing pressures model. During the pandemic, home care nurses and managers experienced both an increased workload and psychosocial strain. For managers, the increased complexity of work was a major problem. We identify three key takeaways related to sustainable crisis management: 1) to support managers' ability to provide social support to their personnel, 2) to increase crisis communication preparedness, and 3) to apply a holistic perspective on protective gear use. We also conclude that the competing pressures model is useful when exploring the dynamics of the work environment in complex organizational contexts.", "doi": "10.1016/j.apergo.2023.104056", "pmid": "37257218", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10230855"}, {"db": "pii", "key": "S0003-6870(23)00094-7"}], "notes": [], "created": "2023-10-04T05:11:54.494Z", "modified": "2023-10-04T07:22:54.879Z"}, {"entity": "publication", "iuid": "2ecacb0f4eee4ef999fdf3621d9fe9bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ecacb0f4eee4ef999fdf3621d9fe9bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ecacb0f4eee4ef999fdf3621d9fe9bd"}}, "title": "High-Density Lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner.", "authors": [{"family": "Correa", "given": "Yubexi", "initials": "Y"}, {"family": "Del Giudice", "given": "Rita", "initials": "R"}, {"family": "Waldie", "given": "Sarah", "initials": "S"}, {"family": "Th\u00e9paut", "given": "Michel", "initials": "M"}, {"family": "Micciula", "given": "Samantha", "initials": "S"}, {"family": "Gerelli", "given": "Yuri", "initials": "Y"}, {"family": "Moulin", "given": "Martine", "initials": "M"}, {"family": "Delaunay", "given": "Clara", "initials": "C"}, {"family": "Fieschi", "given": "Franck", "initials": "F"}, {"family": "Pichler", "given": "Harald", "initials": "H"}, {"family": "Haertlein", "given": "Michael", "initials": "M"}, {"family": "Forsyth", "given": "V Trevor", "initials": "VT"}, {"family": "Le Brun", "given": "Anton", "initials": "A"}, {"family": "Moir", "given": "Michael", "initials": "M"}, {"family": "Russell", "given": "Robert A", "initials": "RA"}, {"family": "Darwish", "given": "Tamim", "initials": "T"}, {"family": "Brinck", "given": "Jonas", "initials": "J"}, {"family": "Wodaje", "given": "Tigist", "initials": "T"}, {"family": "Jansen", "given": "Martin", "initials": "M"}, {"family": "Mart\u00edn", "given": "C\u00e9sar", "initials": "C"}, {"family": "Roosen-Runge", "given": "Felix", "initials": "F"}, {"family": "C\u00e1rdenas", "given": "Marit\u00e9", "initials": "M"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "J Colloid Interface Sci", "issn": "1095-7103", "issn-l": null, "volume": "645", "issue": null, "pages": "627-638"}, "abstract": "There is a close relationship between the SARS-CoV-2 virus and lipoproteins, in particular high-density lipoprotein (HDL). The severity of the coronavirus disease 2019 (COVID-19) is inversely correlated with HDL plasma levels. It is known that the SARS-CoV-2 spike (S) protein binds the HDL particle, probably depleting it of lipids and altering HDL function. Based on neutron reflectometry (NR) and the ability of HDL to efflux cholesterol from macrophages, we confirm these observations and further identify the preference of the S protein for specific lipids and the consequent effects on HDL function on lipid exchange ability. Moreover, the effect of the S protein on HDL function differs depending on the individuals lipid serum profile. Contrasting trends were observed for individuals presenting low triglycerides/high cholesterol serum levels (LTHC) compared to high triglycerides/high cholesterol (HTHC) or low triglycerides/low cholesterol serum levels (LTLC). Collectively, these results suggest that the S protein interacts with the HDL particle and, depending on the lipid profile of the infected individual, it impairs its function during COVID-19 infection, causing an imbalance in lipid metabolism.", "doi": "10.1016/j.jcis.2023.04.137", "pmid": "37167912", "labels": {"Category: Proteins": null, "Funder: VR": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10147446"}, {"db": "pii", "key": "S0021-9797(23)00736-1"}], "notes": [], "created": "2023-10-04T05:08:45.936Z", "modified": "2023-10-04T05:21:15.338Z"}, {"entity": "publication", "iuid": "3acca2f1e999419c83c69f0d31ced23d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3acca2f1e999419c83c69f0d31ced23d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3acca2f1e999419c83c69f0d31ced23d"}}, "title": "High seroprevalence of SARS-CoV-2 antibodies in healthcare workers in COVID-19 wards indicates an occupational hazard-a prospective cohort study during the first year of the COVID-19 pandemic in Kalmar County, Sweden.", "authors": [{"family": "Hultqvist", "given": "Viktor", "initials": "V"}, {"family": "Bonnedahl", "given": "Jonas", "initials": "J"}, {"family": "Edwardsson", "given": "Jonathan", "initials": "J"}, {"family": "Tjernberg", "given": "Ivar", "initials": "I"}, {"family": "Ryd\u00e9n", "given": "Ingvar", "initials": "I"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "APMIS", "issn": "1600-0463", "issn-l": null, "volume": "131", "issue": "9", "pages": "491-497"}, "abstract": "The aim of this study is to report the seroprevalence of SARS-CoV-2 antibodies in healthcare workers with various risk of occupational exposure in Kalmar County, Sweden, during the first year of the coronavirus disease 2019 (COVID-19) pandemic. We performed SARS-CoV-2 antibody measurements at four time points, from May 2020 to May 2021, in 401 healthcare workers (HCW) at seven hospital wards and two residential care facilities, with different risk of SARS-CoV-2 exposure. Overall, the prevalence of SARS-CoV-2 antibodies in HCW in Kalmar County was high compared to similar studies from other countries and increased from May 2020 to May 2021. Initially, 14% of the participants were SARS-CoV-2 seropositive. This number increased to 18% in September and 21% in December 2020. In May 2021, the prevalence of antibodies to nucleocapsid antigen had increased to 28%, while antibodies to spike protein had increased to 95% due to vaccination. A large variation in seroprevalence between different wards was detected and HCW in a COVID-19 designated ward had significantly higher seroprevalence than HCW working in wards without COVID-19 patients, with a risk ratio of 7.28, (95% CI 2.38-22.33) in May 2020. Our findings suggest a relationship between occupational COVID-19 exposure and seropositivity which implies that efficient hygiene routines for health- and social care workers are essential to avoid that COVID-19 care will constitute an occupational hazard.", "doi": "10.1111/apm.13343", "pmid": "37462243", "labels": {"Type: Journal article": null, "Category: Serology": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:07:30.080Z", "modified": "2023-10-04T12:15:22.937Z"}, {"entity": "publication", "iuid": "e75991c1750c4f7786ccf65e35dbb1fb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e75991c1750c4f7786ccf65e35dbb1fb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e75991c1750c4f7786ccf65e35dbb1fb"}}, "title": "High fatigue scores in patients with idiopathic inflammatory myopathies: a multigroup comparative study from the COVAD e-survey.", "authors": [{"family": "Grignaschi", "given": "Silvia", "initials": "S"}, {"family": "Kim", "given": "Minchul", "initials": "M", "orcid": "0000-0001-9737-6255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd2952c6167b4733bfbce019a162b310.json"}}, {"family": "Zanframundo", "given": "Giovanni", "initials": "G"}, {"family": "Ravichandran", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Kardes", "given": "Sinan", "initials": "S", "orcid": "0000-0002-6311-8634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2900c3ca00da476a8914574384a3c9c2.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "COVAD study group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Rheumatol Int", "issn": "1437-160X", "issn-l": null, "volume": "43", "issue": "9", "pages": "1637-1649"}, "abstract": "Idiopathic inflammatory myopathies (IIMs) confer a significant risk of disability and poor quality of life, though fatigue, an important contributing factor, remains under-reported in these individuals. We aimed to compare and analyze differences in visual analog scale (VAS) scores (0-10 cm) for fatigue (VAS-F) in patients with IIMs, non-IIM systemic autoimmune diseases (SAIDs), and healthy controls (HCs). We performed a cross-sectional analysis of the data from the COVID-19 Vaccination in Autoimmune Diseases (COVAD) international patient self-reported e-survey. The COVAD survey was circulated from December 2020 to August 2021, and details including demographics, COVID-19 history, vaccination details, SAID details, global health, and functional status were collected from adult patients having received at least one COVID-19 vaccine dose. Fatigue experienced 1 week prior to survey completion was assessed using a single-item 10 cm VAS. Determinants of fatigue were analyzed in regression models. Six thousand nine hundred and eighty-eight respondents (mean age 43.8 years, 72% female; 55% White) were included in the analysis. The overall VAS-F score was 3 (IQR 1-6). Patients with IIMs had similar fatigue scores (5, IQR 3-7) to non-IIM SAIDs [5 (IQR 2-7)], but higher compared to HCs (2, IQR 1-5; P < 0.001), regardless of disease activity. In adjusted analysis, higher VAS-F scores were seen in females (reference female; coefficient -0.17; 95%CI -0.21 to -13; P < 0.001) and Caucasians (reference Caucasians; coefficient -0.22; 95%CI -0.30 to -0.14; P < 0.001 for Asians and coefficient -0.08; 95%CI -0.13 to 0.30; P = 0.003 for Hispanics) in our cohort. Our study found that patients with IIMs exhibit considerable fatigue, similar to other SAIDs and higher than healthy individuals. Women and Caucasians experience greater fatigue scores, allowing identification of stratified groups for optimized multidisciplinary care and improve outcomes such as quality of life.", "doi": "10.1007/s00296-023-05344-z", "pmid": "37314497", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Funder: H2020": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10265550"}, {"db": "pii", "key": "10.1007/s00296-023-05344-z"}], "notes": [], "created": "2023-10-04T09:32:31.580Z", "modified": "2023-10-04T11:09:52.683Z"}, {"entity": "publication", "iuid": "bf31b0ac62cb410db050e9b0a752e1aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf31b0ac62cb410db050e9b0a752e1aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf31b0ac62cb410db050e9b0a752e1aa"}}, "title": "Exploring the learning needs of clinicians in Belgium and Sweden regarding prone positioning and skin damage prevention: A qualitative study.", "authors": [{"family": "Fourie", "given": "Anika", "initials": "A"}, {"family": "Karlberg-Traav", "given": "Malin", "initials": "M"}, {"family": "Dahlberg", "given": "Karuna", "initials": "K"}, {"family": "Hanssens", "given": "Valerie", "initials": "V"}, {"family": "Smet", "given": "Steven", "initials": "S"}, {"family": "Jaensson", "given": "Maria", "initials": "M"}, {"family": "Beeckman", "given": "Dimitri", "initials": "D"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Nurse Educ Today", "issn": "1532-2793", "issn-l": null, "volume": "128", "issue": null, "pages": "105860"}, "abstract": "During the coronavirus pandemic (COVID -19), the use of prone positioning in critically ill patients with acute respiratory distress syndrome (ARDS) increased substantially. As a result, clinicians had to (re)learn how to treat the patient in the prone position while preventing adverse events such as pressure ulcers, skin tears and moisture-associated skin damage.\r\n\r\nThe purpose of the study was to determine participants' learning needs related to patients in the prone position and the prevention of skin damage, such as pressure ulcers, and what they perceived as a positive or negative learning experience.\r\n\r\nThis study used a qualitative methodological framework and employed an exploratory design.\r\n\r\nA purposive sample of clinicians (n = 20) with direct or indirect work experience with prone ventilated patients was recruited in Belgium and Sweden.\r\n\r\nIndividual semi-structured interviews were conducted in Belgium and Sweden between February and August 2022. Data were analysed thematically using an inductive approach. The COREQ guideline was utilised to comprehensively report on the study.\r\n\r\nTwo themes were identified: 'Adapting to a crisis' and 'How to learn', with the latter having two subthemes: 'balancing theory and practice' and 'co-creating knowledge'. Unexpected circumstances necessitated a personal adaption, a change in learning methods and a pragmatic adaptation of protocols, equipment and working procedures. Participants recognised a multifaceted educational approach which would contribute to a positive learning experience regarding prone positioning and skin damage prevention. The importance of poising theoretical teaching with practical hands-on training was highlighted with an emphasis on interaction, discussion, and networking between peers.\r\n\r\nThe study findings highlight learning approaches which may help inform the development of befitting educational resources for clinicians. Prone therapy for ARDS patients is not limited to the pandemic. Therefore, educational efforts should continue to ensure patient safety in this important area.", "doi": "10.1016/j.nedt.2023.105860", "pmid": "37302346", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10245459"}, {"db": "pii", "key": "S0260-6917(23)00154-5"}], "notes": [], "created": "2023-10-04T09:33:11.219Z", "modified": "2023-10-04T11:19:39.322Z"}, {"entity": "publication", "iuid": "84557420b4864451a9d76aff69578f14", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84557420b4864451a9d76aff69578f14.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84557420b4864451a9d76aff69578f14"}}, "title": "Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2.", "authors": [{"family": "Yang", "given": "Pei-Pei", "initials": "P"}, {"family": "Ye", "given": "Xin-Wei", "initials": "X"}, {"family": "Liu", "given": "Mei-Qin", "initials": "M"}, {"family": "Yang", "given": "Jin-Xuan", "initials": "J"}, {"family": "Feng", "given": "Xiao-Li", "initials": "X"}, {"family": "Li", "given": "Yi-Jing", "initials": "Y"}, {"family": "Zhang", "given": "Kuo", "initials": "K"}, {"family": "Liang", "given": "Hong-Wen", "initials": "H"}, {"family": "Yi", "given": "Yu", "initials": "Y"}, {"family": "Wang", "given": "Lei", "initials": "L", "orcid": "0000-0003-1405-9815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30c6dba79ded4fd1b628ddfd5daf494f.json"}}, {"family": "Liu", "given": "Yi-Xuan", "initials": "Y"}, {"family": "Yang", "given": "Xing-Lou", "initials": "X"}, {"family": "Shi", "given": "Zheng-Li", "initials": "Z"}, {"family": "Feng", "given": "Li-Qiang", "initials": "L"}, {"family": "Chen", "given": "Ling", "initials": "L"}, {"family": "Xue", "given": "Yintong", "initials": "Y"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}, {"family": "Wang", "given": "Hao", "initials": "H"}, {"family": "Zhao", "given": "Yuliang", "initials": "Y"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Adv Healthc Mater", "issn": "2192-2659", "issn-l": null, "volume": "12", "issue": "24", "pages": "e2300673"}, "abstract": "The viral spike (S) protein on the surface of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin-converting enzyme 2 (ACE2) receptors on the host cells, facilitating its entry and infection. Here, functionalized nanofibers targeting the S protein with peptide sequences of IRQFFKK, WVHFYHK and NSGGSVH, which are screened from a high-throughput one-bead one-compound screening strategy, are designed and prepared. The flexible nanofibers support multiple binding sites and efficiently entangle SARS-CoV-2, forming a nanofibrous network that blocks the interaction between the S protein of SARS-CoV-2 and the ACE2 on host cells, and efficiently reduce the invasiveness of SARS-CoV-2. In summary, nanofibers entangling represents a smart nanomedicine for the prevention of SARS-CoV-2.", "doi": "10.1002/adhm.202300673", "pmid": "37139567", "labels": {"Category: Proteins": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:11:52.046Z", "modified": "2023-10-04T07:22:10.555Z"}, {"entity": "publication", "iuid": "4ec4a4b1a1fc4bcda2fabd8ba091ed1b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ec4a4b1a1fc4bcda2fabd8ba091ed1b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ec4a4b1a1fc4bcda2fabd8ba091ed1b"}}, "title": "Digital health funding for COVID-19 vaccine deployment across four major donor agencies.", "authors": [{"family": "Helld\u00e9n", "given": "Daniel", "initials": "D"}, {"family": "Tesfaye", "given": "Sophia", "initials": "S"}, {"family": "Gachen", "given": "Carine", "initials": "C"}, {"family": "Lindstrand", "given": "Ann", "initials": "A"}, {"family": "K\u00e4llander", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "The Lancet Digital Health", "issn": "2589-7500", "issn-l": null, "volume": "5", "issue": "9", "pages": "e627-e631"}, "abstract": "The international response to the COVID-19 pandemic provided opportunities for countries to use digital technologies for vaccine deployment and associated activities, but misaligned digital investments could weaken or fragment national systems. In this review of 311 funding applications from 120 country governments to four donor agencies (UNICEF; Gavi, the Vaccine Alliance; the Global Fund to Fight AIDS, Tuberculosis and Malaria; and the World Bank) up to May 1, 2022, we found that 272 (87%) of the applications included at least one digital aspect and that substantial funding has been dedicated towards digital aspects from donors. The majority of digital aspects concerned immunisation information systems, vaccine acceptance and uptake, and COVID-19 surveillance. As the global community sets its sights on a COVID-19-free world, continued coordinated investments in digital health and health information systems for pandemic preparedness and response will be key to strengthening the resilience of health systems.", "doi": "10.1016/S2589-7500(23)00134-6", "pmid": "37625897", "labels": {"Category: Other": null, "Category: Vaccines": null, "Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2589-7500(23)00134-6"}], "notes": [], "created": "2023-10-05T08:08:39.770Z", "modified": "2023-10-06T04:31:10.944Z"}, {"entity": "publication", "iuid": "63b101b848ae4630a61c9b89c8877dcf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63b101b848ae4630a61c9b89c8877dcf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63b101b848ae4630a61c9b89c8877dcf"}}, "title": "Cognitive ability, health policy, and the dynamics of COVID-19 vaccination.", "authors": [{"family": "Elinder", "given": "Mikael", "initials": "M"}, {"family": "Erixson", "given": "Oscar", "initials": "O"}, {"family": "\u00d6hman", "given": "Mattias", "initials": "M"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "J Health Econ", "issn": "1879-1646", "issn-l": null, "volume": "91", "issue": null, "pages": "102802"}, "abstract": "We examine the relationship between cognitive ability and prompt COVID-19 vaccination using individual-level data on more than 700,000 individuals in Sweden. We find a strong positive association between cognitive ability and swift vaccination, which remains even after controlling for confounding variables with a twin-design. The results suggest that the complexity of the vaccination decision may make it difficult for individuals with lower cognitive abilities to understand the benefits of vaccination. Consistent with this, we show that simplifying the vaccination decision through pre-booked vaccination appointments alleviates almost all of the inequality in vaccination behavior.", "doi": "10.1016/j.jhealeco.2023.102802", "pmid": "37672962", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0167-6296(23)00079-6"}], "notes": [], "created": "2023-10-06T06:56:51.941Z", "modified": "2023-10-06T11:31:47.711Z"}, {"entity": "publication", "iuid": "a7e27207e7a94cd8aff08881f2864f65", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7e27207e7a94cd8aff08881f2864f65.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7e27207e7a94cd8aff08881f2864f65"}}, "title": "A standardised protocol for relative SARS-CoV-2 variant severity assessment, applied to Omicron BA.1 and Delta in six European countries, October 2021 to February 2022.", "authors": [{"family": "Nyberg", "given": "Tommy", "initials": "T"}, {"family": "Bager", "given": "Peter", "initials": "P"}, {"family": "Svalgaard", "given": "Ingrid Bech", "initials": "IB"}, {"family": "Bejko", "given": "Dritan", "initials": "D"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Evans", "given": "Josie", "initials": "J"}, {"family": "Krause", "given": "Tyra Grove", "initials": "TG"}, {"family": "McMenamin", "given": "Jim", "initials": "J"}, {"family": "Mossong", "given": "Jo\u00ebl", "initials": "J"}, {"family": "Mutch", "given": "Heather", "initials": "H"}, {"family": "Omokanye", "given": "Ajibola", "initials": "A"}, {"family": "Peralta-Santos", "given": "Andr\u00e9", "initials": "A"}, {"family": "Pinto-Leite", "given": "Pedro", "initials": "P"}, {"family": "Starrfelt", "given": "Jostein", "initials": "J"}, {"family": "Thelwall", "given": "Simon", "initials": "S"}, {"family": "Veneti", "given": "Lamprini", "initials": "L"}, {"family": "Whittaker", "given": "Robert", "initials": "R"}, {"family": "Wood", "given": "John", "initials": "J"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "Presanis", "given": "Anne M", "initials": "AM"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "36", "pages": null}, "abstract": "Several SARS-CoV-2 variants that evolved during the COVID-19 pandemic have appeared to differ in severity, based on analyses of single-country datasets. With decreased testing and sequencing, international collaborative studies will become increasingly important for timely assessment of the severity of new variants. Therefore, a joint WHO Regional Office for Europe and ECDC working group was formed to produce and pilot a standardised study protocol to estimate relative case-severity of SARS-CoV-2 variants during periods when two variants were co-circulating. The study protocol and its associated statistical analysis code was applied by investigators in Denmark, England, Luxembourg, Norway, Portugal and Scotland to assess the severity of cases with the Omicron BA.1 virus variant relative to Delta. After pooling estimates using meta-analysis methods (random effects estimates), the risk of hospital admission (adjusted hazard ratio (aHR) = 0.41; 95% confidence interval (CI): 0.31-0.54), admission to intensive care unit (aHR = 0.12; 95% CI: 0.05-0.27) and death (aHR = 0.31; 95% CI: 0.28-0.35) was lower for Omicron BA.1 compared with Delta cases. The aHRs varied by age group and vaccination status. In conclusion, this study demonstrates the feasibility of conducting variant severity analyses in a multinational collaborative framework and adds evidence for the reduced severity of the Omicron BA.1 variant.", "doi": "10.2807/1560-7917.ES.2023.28.36.2300048", "pmid": "37676146", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10486193"}], "notes": [], "created": "2023-10-06T06:55:12.366Z", "modified": "2023-10-06T10:47:20.690Z"}, {"entity": "publication", "iuid": "4e8767b8b6054dbeaab6dfe907ae7b97", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4e8767b8b6054dbeaab6dfe907ae7b97.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4e8767b8b6054dbeaab6dfe907ae7b97"}}, "title": "A randomised phase 2a study to investigate the effects of blocking interleukin-33 with tozorakimab in patients hospitalised with COVID-19: ACCORD-2.", "authors": [{"family": "Wilkinson", "given": "Tom", "initials": "T", "orcid": "0000-0003-1771-3851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3239563fcce145ee8d4ab7d35b43a2ad.json"}}, {"family": "De Soyza", "given": "Anthony", "initials": "A", "orcid": "0000-0002-8566-0344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1dc6ec2385014db6aad8bbd5a246ed68.json"}}, {"family": "Carroll", "given": "Miles", "initials": "M", "orcid": "0000-0002-7026-7187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d55790d02914f88a2df413b99c59749.json"}}, {"family": "Chalmers", "given": "James D", "initials": "JD", "orcid": "0000-0001-5514-7868", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37d2cc32f79448a28df83f9ee728cac3.json"}}, {"family": "Crooks", "given": "Michael G", "initials": "MG"}, {"family": "Griffiths", "given": "Gareth", "initials": "G"}, {"family": "Shankar-Hari", "given": "Manu", "initials": "M", "orcid": "0000-0002-5338-2538", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/490ca05f76804685bf9fec3adfa0b0a0.json"}}, {"family": "Ho", "given": "Ling-Pei", "initials": "L"}, {"family": "Horsley", "given": "Alex", "initials": "A", "orcid": "0000-0003-1828-0058", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/088d99884f4642dab5297a7864ef1fe1.json"}}, {"family": "Kell", "given": "Chris", "initials": "C"}, {"family": "Lara", "given": "Beatriz", "initials": "B", "orcid": "0000-0003-0090-8206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d115da5d1e0246af8f08f70a4e9266c4.json"}}, {"family": "Mishra", "given": "Biswa", "initials": "B"}, {"family": "Moate", "given": "Rachel", "initials": "R"}, {"family": "Page", "given": "Clive", "initials": "C"}, {"family": "Pandya", "given": "Hitesh", "initials": "H"}, {"family": "Raw", "given": "Jason", "initials": "J"}, {"family": "Reid", "given": "Fred", "initials": "F"}, {"family": "Saralaya", "given": "Dinesh", "initials": "D"}, {"family": "Scott", "given": "Ian C", "initials": "IC"}, {"family": "Siddiqui", "given": "Salman", "initials": "S"}, {"family": "Ustianowski", "given": "Andy", "initials": "A"}, {"family": "van Zuydam", "given": "Natalie", "initials": "N"}, {"family": "Woodcock", "given": "Ashley", "initials": "A", "orcid": "0000-0002-5428-8578", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d3fb0de3ce5b4352876837cd518b332a.json"}}, {"family": "Singh", "given": "Dave", "initials": "D", "orcid": "0000-0001-8918-7075", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f87ffcbf55547c7832731e3479d55bd.json"}}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "ERJ Open Res", "issn": "2312-0541", "issn-l": null, "volume": "9", "issue": "5", "pages": null}, "abstract": "Increased serum interleukin (IL)-33 predicts poor outcomes in patients hospitalised with coronavirus disease 2019 (COVID-19). We examined the efficacy and safety of tozorakimab, a monoclonal antibody that neutralises IL-33, in improving outcomes in ACCORD-2 (EudraCT: 2020-001736-95).\r\n\r\nACCORD-2 was an open-label, phase 2a study in adults hospitalised with COVID-19. Patients were randomised 1:1 to tozorakimab 300 mg plus standard of care (SoC) or SoC alone. The primary end-point was time to clinical response (sustained clinical improvement of \u22652 points on the World Health Organization ordinal scale, discharge from hospital or fit for discharge) by day 29. Other end-points included death or respiratory failure, mortality and intensive care unit admission by day 29, and safety. Serum IL-33/soluble stimulated-2 (sST2) complex levels were measured by high-sensitivity immunoassay.\r\n\r\nEfficacy analyses included 97 patients (tozorakimab+SoC, n=53; SoC, n=44). Median time to clinical response did not differ between the tozorakimab and SoC arms (8.0 and 9.5 days, respectively; HR 0.96, 80% CI 0.70-1.31; one-sided p=0.33). Tozorakimab was well tolerated and the OR for risk of death or respiratory failure with treatment versus SoC was 0.55 (80% CI 0.27-1.12; p=0.26), while the OR was 0.31 (80% CI 0.09-1.06) in patents with high baseline serum IL-33/sST2 complex levels.\r\n\r\nOverall, ACCORD-2 results suggest that tozorakimab could be a novel therapy for patients hospitalised with COVID-19, warranting further investigation in confirmatory phase 3 studies.", "doi": "10.1183/23120541.00249-2023", "pmid": "37868151", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10588785"}, {"db": "pii", "key": "00249-2023"}], "notes": [], "created": "2023-11-01T13:34:04.363Z", "modified": "2023-11-02T07:40:47.429Z"}, {"entity": "publication", "iuid": "0253ecf537a940588afeebc1bcd7406c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0253ecf537a940588afeebc1bcd7406c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0253ecf537a940588afeebc1bcd7406c"}}, "title": "Alcohol consumption under lockdown measures during the COVID-19 pandemic in three Nordic countries.", "authors": [{"family": "Gunnerlind", "given": "Oscar", "initials": "O", "orcid": "0000-0003-2856-0192", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd5a54cbaeee4a89932f208c10fd5d0a.json"}}, {"family": "Lundqvist", "given": "Robert", "initials": "R"}, {"family": "Ott", "given": "Michael", "initials": "M"}, {"family": "Werneke", "given": "Ursula", "initials": "U", "orcid": "0000-0002-5023-3254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eed3b002ddb4cbba141cbfdc8d3f032.json"}}], "type": "journal article", "published": "2023-08-31", "journal": {"title": "Int J Soc Psychiatry", "issn": "1741-2854", "issn-l": null, "volume": null, "issue": null, "pages": "207640231194486"}, "abstract": "At the beginning of the COVID-19 pandemic, concerns arose about a possible rise in alcohol consumption. Early surveys, however, more commonly pointed towards a decrease of alcohol use. But studies based on self-reports may underestimate alcohol use. They also depend on the population sampled. Because of border closures and gastronomy restrictions, countries with centralised alcohol sales provided a unique opportunity to study total domestic consumption during the pandemic without influence of private import or reliance on self-reports.\r\n\r\nWe examined the correlation between alcohol sales and national COVID-19 restrictions in three such countries, Finland, Norway and Sweden.\r\n\r\nWe conducted this study as a mirror image study, comparing alcohol sales during the first 2 years of the COVID-19 pandemic with the two preceding years. We explored hours of daylight/season as potential confounders.\r\n\r\nWe found no relevant change in alcohol sales during the pandemic years for Finland or Sweden. For Norway, there was a level-change in sales, which could be explained by decreased imports. Sales followed a seasonal pattern. In all three countries, the initial pandemic increase in alcohol sales coincided with an underlying annually recurring seasonal variation.\r\n\r\nThe COVID-19 pandemic had less of an impact on alcohol consumption in the three Nordic countries than could intuitively be expected. The increase of alcohol sales at the beginning of the COVID-19 pandemic coincided with a seasonal rise following a pre-pandemic pattern. Therefore, caution should be exercised with drawing conclusions from data with a short time perspective to avoid attribution bias.", "doi": "10.1177/00207640231194486", "pmid": "37650471", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:02:41.240Z", "modified": "2023-10-05T08:49:41.393Z"}, {"entity": "publication", "iuid": "659e1b32ed7d47b7a951e42b964496a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/659e1b32ed7d47b7a951e42b964496a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/659e1b32ed7d47b7a951e42b964496a6"}}, "title": "Addressing health inequity during the COVID-19 pandemic through primary health care and public health collaboration: a multiple case study analysis in eight high-income countries.", "authors": [{"family": "Vanden Bossche", "given": "Dorien", "initials": "D"}, {"family": "Zhao", "given": "Q Jane", "initials": "QJ"}, {"family": "Ares-Blanco", "given": "Sara", "initials": "S"}, {"family": "Pe\u00f1a", "given": "Maria Pilar Astier", "initials": "MPA"}, {"family": "Decat", "given": "Peter", "initials": "P"}, {"family": "Kondo", "given": "Naoki", "initials": "N"}, {"family": "Kroneman", "given": "Madelon", "initials": "M"}, {"family": "Nishioka", "given": "Daisuke", "initials": "D"}, {"family": "Petrazzuoli", "given": "Ferdinando", "initials": "F"}, {"family": "Rortveit", "given": "Guri", "initials": "G"}, {"family": "Schaubroeck", "given": "Emmily", "initials": "E"}, {"family": "Stark", "given": "Stefanie", "initials": "S"}, {"family": "Pinto", "given": "Andrew D", "initials": "AD"}, {"family": "Willems", "given": "Sara", "initials": "S"}], "type": "journal article", "published": "2023-08-31", "journal": {"title": "Int J Equity Health", "issn": "1475-9276", "issn-l": null, "volume": "22", "issue": "1", "pages": "171"}, "abstract": "The COVID-19 pandemic substantially magnified the inequity gaps among vulnerable populations. Both public health (PH) and primary health care (PHC) have been crucial in addressing the challenges posed by the pandemic, especially in the area of vulnerable populations. However, little is known about the intersection between PH and PHC as a strategy to mitigate the inequity gap. This study aims to assess the collaboration between PHC and PH with a focus on addressing the health needs of vulnerable populations during the COVID-19 pandemic across jurisdictions.\r\n\r\nWe analyzed and compared data from jurisdictional reports of COVID-19 pandemic responses in PHC and PH in Belgium, Canada (Ontario), Germany, Italy, Japan, the Netherlands, Norway, and Spain from 2020 to 2021.\r\n\r\nFour themes emerge from the analysis: (1) the majority of the countries implemented outreach strategies targeting vulnerable groups as a means to ensure continued access to PHC; (2) digital assessment in PHC was found to be present across all the countries; (3) PHC was insufficiently represented at the decision-making level; (4) there is a lack of clear communication channels between PH and PHC in all the countries.\r\n\r\nThis study identified opportunities for collaboration between PHC and PH to reduce inequity gaps and to improve population health, focusing on vulnerable populations. The COVID-19 response in these eight countries has demonstrated the importance of an integrated PHC system. Consequently, the development of effective strategies for responding to and planning for pandemics should take into account the social determinants of health in order to mitigate the unequal impact of COVID-19. Careful, intentional coordination between PH and PHC should be established in normal times as a basis for effective response during future public health emergencies. The pandemic has provided significant insights on how to strengthen health systems and provide universal access to healthcare by fostering stronger connections between PH and PHC.", "doi": "10.1186/s12939-023-01968-6", "pmid": "37653472", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10472729"}, {"db": "pii", "key": "10.1186/s12939-023-01968-6"}], "notes": [], "created": "2023-10-06T06:56:38.772Z", "modified": "2023-10-06T11:24:37.724Z"}, {"entity": "publication", "iuid": "f434c2ddde2e47c7b06209913c57337d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f434c2ddde2e47c7b06209913c57337d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f434c2ddde2e47c7b06209913c57337d"}}, "title": "Super-resolution proximity labeling reveals anti-viral protein network and its structural changes against SARS-CoV-2 viral proteins.", "authors": [{"family": "Lee", "given": "Yun-Bin", "initials": "Y"}, {"family": "Jung", "given": "Minkyo", "initials": "M"}, {"family": "Kim", "given": "Jeesoo", "initials": "J"}, {"family": "Charles", "given": "Afandi", "initials": "A"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Kang", "given": "Jiwoong", "initials": "J"}, {"family": "Kang", "given": "Myeong-Gyun", "initials": "M"}, {"family": "Kwak", "given": "Chulhwan", "initials": "C"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Kim", "given": "Jong-Seo", "initials": "J"}, {"family": "Mun", "given": "Ji Young", "initials": "JY"}, {"family": "Rhee", "given": "Hyun-Woo", "initials": "H"}], "type": "journal article", "published": "2023-08-29", "journal": {"title": "Cell Rep", "issn": "2211-1247", "issn-l": null, "volume": "42", "issue": "8", "pages": "112835"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in human cells by interacting with host factors following infection. To understand the virus and host interactome proximity, we introduce a super-resolution proximity labeling (SR-PL) method with a \"plug-and-playable\" PL enzyme, TurboID-GBP (GFP-binding nanobody protein), and we apply it for interactome mapping of SARS-CoV-2 ORF3a and membrane protein (M), which generates highly perturbed endoplasmic reticulum (ER) structures. Through SR-PL analysis of the biotinylated interactome, 224 and 272 peptides are robustly identified as ORF3a and M interactomes, respectively. Within the ORF3a interactome, RNF5 co-localizes with ORF3a and generates ubiquitin modifications of ORF3a that can be involved in protein degradation. We also observe that the SARS-CoV-2 infection rate is efficiently reduced by the overexpression of RNF5 in host cells. The interactome data obtained using the SR-PL method are presented at https://sarscov2.spatiomics.org. We hope that our method will contribute to revealing virus-host interactions of other viruses in an efficient manner.", "doi": "10.1016/j.celrep.2023.112835", "pmid": "37478010", "labels": {"Type: Journal article": null, "Category: Proteins": null}, "xrefs": [{"db": "pii", "key": "S2211-1247(23)00846-X"}], "notes": [], "created": "2023-10-04T12:10:26.384Z", "modified": "2023-10-04T13:13:13.239Z"}, {"entity": "publication", "iuid": "90c3a6e606bf4d3ca62e2f8c6def2741", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90c3a6e606bf4d3ca62e2f8c6def2741.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90c3a6e606bf4d3ca62e2f8c6def2741"}}, "title": "Prepandemic personal concentrations of per- and polyfluoroalkyl substances (PFAS) and other pollutants: Specific and combined effects on the incidence of COVID-19 disease and SARS-CoV-2 infection.", "authors": [{"family": "Pumarega", "given": "Jos\u00e9", "initials": "J"}, {"family": "Gasull", "given": "Magda", "initials": "M"}, {"family": "Koponen", "given": "Jani", "initials": "J"}, {"family": "Campi", "given": "Laura", "initials": "L"}, {"family": "Rantakokko", "given": "Panu", "initials": "P"}, {"family": "Henr\u00edquez-Hern\u00e1ndez", "given": "Luis A", "initials": "LA"}, {"family": "Aguilar", "given": "Ruth", "initials": "R"}, {"family": "Donat-Vargas", "given": "Carolina", "initials": "C"}, {"family": "Zumbado", "given": "Manuel", "initials": "M"}, {"family": "Villar-Garc\u00eda", "given": "Judit", "initials": "J"}, {"family": "Rius", "given": "Cristina", "initials": "C"}, {"family": "Santiago-D\u00edaz", "given": "Pablo", "initials": "P"}, {"family": "Vidal", "given": "Marta", "initials": "M"}, {"family": "Jimenez", "given": "Alfons", "initials": "A"}, {"family": "Iglesias", "given": "Mar", "initials": "M"}, {"family": "Doba\u00f1o", "given": "Carlota", "initials": "C"}, {"family": "Moncunill", "given": "Gemma", "initials": "G"}, {"family": "Porta", "given": "Miquel", "initials": "M"}], "type": "journal article", "published": "2023-08-29", "journal": {"title": "Environ Res", "issn": "1096-0953", "issn-l": "0013-9351", "volume": "237", "issue": "Pt 2", "pages": "116965"}, "abstract": "To investigate the specific and combined effects of personal concentrations of some per- and polyfluoroalkyl substances (PFAS), other persistent organic pollutants (POPs), and chemical elements -measured in individuals' blood several years before the pandemic- on the development of SARS-CoV-2 infection and COVID-19 disease in the general population.\r\n\r\nWe conducted a prospective cohort study in 240 individuals from the general population of Barcelona. PFAS, other POPs, and chemical elements were measured in plasma, serum, and whole blood samples, respectively, collected in 2016-2017. PFAS were analyzed by liquid chromatography-triple quadrupole mass spectrometry. SARS-CoV-2 infection was detected by rRT-PCR in nasopharyngeal swabs and/or antibody serology in blood samples collected in 2020-2021.\r\n\r\nNo individual PFAS nor their mixtures were significantly associated with SARS-CoV-2 seropositivity or COVID-19 disease. Previously identified mixtures of POPs and elements (Porta et al., 2023) remained significantly associated with seropositivity and COVID-19 when adjusted for PFAS (all OR > 4 or p < 0.05). Nine chemicals comprised mixtures associated with COVID-19: thallium, ruthenium, lead, benzo[b]fluoranthene, DDD, other DDT-related compounds, manganese, tantalum, and aluminium. And nine chemicals comprised the mixtures more consistently associated with SARS-CoV-2 seropositivity: thallium, ruthenium, lead, benzo[b]fluoranthene, DDD, gold, and (protectively) selenium, indium, and iron.\r\n\r\nThe PFAS studied were not associated with SARS-CoV-2 seropositivity or COVID-19. The results confirm the associations between personal blood concentrations of some POPs and chemical elements and the risk of COVID-19 and SARS-CoV-2 infection in what remains the only prospective and population-based cohort study on the topic. Mixtures of POPs and chemical elements may contribute to explain the heterogeneity in the risks of SARS-CoV-2 infection and COVID-19 in the general population.", "doi": "10.1016/j.envres.2023.116965", "pmid": "37652221", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0013-9351(23)01769-3"}], "notes": [], "created": "2023-10-06T06:52:13.472Z", "modified": "2023-10-06T08:27:52.331Z"}, {"entity": "publication", "iuid": "670370e2a10447ef97d64d892dc77928", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/670370e2a10447ef97d64d892dc77928.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/670370e2a10447ef97d64d892dc77928"}}, "title": "Long-term survival after intensive care for COVID-19: a nationwide cohort study of more than 8000 patients.", "authors": [{"family": "H\u00e4ggl\u00f6f", "given": "Elsa", "initials": "E", "orcid": "0000-0001-7741-8980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9298066f63df45aaa4ce3d8b54d14fb6.json"}}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "Zettersten", "given": "Erik", "initials": "E"}, {"family": "Engerstr\u00f6m", "given": "Lars", "initials": "L"}, {"family": "Larsson", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2023-08-29", "journal": {"title": "Ann Intensive Care", "issn": "2110-5820", "issn-l": null, "volume": "13", "issue": "1", "pages": "76"}, "abstract": "Was it worth it-what is the outcome after the extended ICU (intensive care unit) length of stay for COVID-19 patients? Surprisingly, data on long-term mortality in large cohorts are lacking. We investigate long-term mortality including differences between men and women, as previous studies show that men generally suffer a more severe course of COVID-19 in terms of severity of illness and short-term mortality.\r\n\r\nNationwide cohort including all adult COVID-19 patients admitted to Swedish ICUs until August 12, 2022. Primary outcome was 360-day mortality after ICU admission. Logistic regression was used to estimate associations between demographics, comorbidities, clinical characteristics and mortality.\r\n\r\nIn total, 8392 patients were included. Median (IQR) age was 63 (52-72) years and the majority (70.1%) were men. Among the 7390 patients with complete 360-day mortality data, 1775 (24.4%) patients died within 30 days, 2125 (28.8%) within 90 days and 2206 (29.8%) within 360 days from ICU admission. 360-day mortality was 27.1% in women and 31.0% in men. Multivariable logistic regression analysis showed increased risk of 360-day mortality in men compared to women (OR: 1.33, 95% CI: 1.17-1.52). Other variables associated with poor 360-day mortality were age, cardiac disease, COPD/asthma, diabetes, immune deficiency, chronic kidney disease, neuromuscular disease, and malignancy.\r\n\r\nThis study confirms the increased severity of disease in critically ill men with COVID-19, even in a long-term perspective. However, mortality beyond 90 days was strikingly low, indicating high probability of survival after the acute phase of illness.", "doi": "10.1186/s13613-023-01156-3", "pmid": "37642833", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC10465451"}, {"db": "pii", "key": "10.1186/s13613-023-01156-3"}], "notes": [], "created": "2023-10-05T08:08:34.880Z", "modified": "2023-10-05T08:54:18.433Z"}, {"entity": "publication", "iuid": "4915a33bdda740cda0a5c21e21012377", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4915a33bdda740cda0a5c21e21012377.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4915a33bdda740cda0a5c21e21012377"}}, "title": "Impact of Risk Factors on COVID-19 Outcomes in Unvaccinated People with Rheumatic Diseases.", "authors": [{"family": "Yazdany", "given": "Jinoos", "initials": "J", "orcid": "0000-0002-3508-4094", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62bbeb3392ce40d482da768af63f5d54.json"}}, {"family": "Ware", "given": "Anna", "initials": "A", "orcid": "0000-0003-3333-7833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6be3cbe46a3b4190a31e190c195f7e77.json"}}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Grainger", "given": "Rebecca", "initials": "R", "orcid": "0000-0001-9201-8678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9d304e9e29a43a5a7a76679c002a876.json"}}, {"family": "Hachulla", "given": "Eric", "initials": "E"}, {"family": "Richez", "given": "Christophe", "initials": "C"}, {"family": "Cacoub", "given": "Patrice", "initials": "P", "orcid": "0000-0002-6727-4992", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fc3b4f8d7994a7fb48f3facfa27baf8.json"}}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS", "orcid": "0000-0003-0786-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d99dc166f48d4af7b8e46dc999c7444b.json"}}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Jacobsohn", "given": "Lindsay", "initials": "L"}, {"family": "Strangfeld", "given": "Anja", "initials": "A"}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL"}, {"family": "Gossec", "given": "Laure", "initials": "L"}, {"family": "Carmona", "given": "Loreto", "initials": "L"}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S", "orcid": "0000-0002-8611-162X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73b17eb08d984421847f733b7a6a49d4.json"}}, {"family": "Kearsley-Fleet", "given": "Lianne", "initials": "L", "orcid": "0000-0003-0377-1575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9cc64aac266462baf67998b3d49c6f7.json"}}, {"family": "Schaefer", "given": "Martin", "initials": "M", "orcid": "0000-0001-6487-3634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb2c617a7902440eb574fcb1141785ac.json"}}, {"family": "Ribeiro", "given": "Sandra Lucia Euzebio", "initials": "SLE", "orcid": "0000-0002-4777-8659", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2db6a09138844b1690855b8b44af31ec.json"}}, {"family": "Al-Emadi", "given": "Samar", "initials": "S", "orcid": "0000-0001-7942-4831", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49a627d387d042f7b99d821d9676d0d5.json"}}, {"family": "Hasseli", "given": "Rebecca", "initials": "R"}, {"family": "M\u00fcller-Ladner", "given": "Ulf", "initials": "U"}, {"family": "Specker", "given": "Christof", "initials": "C"}, {"family": "Schulze-Koops", "given": "Hendrik", "initials": "H"}, {"family": "Bernardes", "given": "Miguel", "initials": "M"}, {"family": "Machado Fraga", "given": "Vanessa", "initials": "V"}, {"family": "Rodrigues", "given": "Ana Maria", "initials": "AM"}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA", "orcid": "0000-0002-5556-4618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/192552e5e3d2435799e57111ea84502d.json"}}, {"family": "Ljung", "given": "Lotta", "initials": "L"}, {"family": "Di Giuseppe", "given": "Daniela", "initials": "D"}, {"family": "Tidblad", "given": "Liselotte", "initials": "L"}, {"family": "Wise", "given": "Leanna", "initials": "L", "orcid": "0000-0002-6172-9474", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a7e415e8715491bb9d0409d4b008443.json"}}, {"family": "Duarte-Garc\u00eda", "given": "Al\u00ed", "initials": "A", "orcid": "0000-0003-1749-5719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77a5555c1b624ba49ee7c729be2aef95.json"}}, {"family": "Ugarte-Gil", "given": "Manuel F", "initials": "MF", "orcid": "0000-0003-1728-1999", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b49a52ac208747ed9b85f286119da620.json"}}, {"family": "Colunga-Pedraza", "given": "Iris Jazm\u00edn", "initials": "IJ", "orcid": "0000-0002-2786-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50e46ef2c7f44b39a1d28fea6a8e621d.json"}}, {"family": "Mart\u00ednez-Mart\u00ednez", "given": "Marco Ulises", "initials": "MU"}, {"family": "Alpizar-Rodriguez", "given": "Deshire", "initials": "D"}, {"family": "Xavier", "given": "Ricardo Machado", "initials": "RM"}, {"family": "Isnardi", "given": "Carolina A", "initials": "CA"}, {"family": "Pera", "given": "Mariana", "initials": "M"}, {"family": "Pons-Estel", "given": "Guillermo", "initials": "G"}, {"family": "Izadi", "given": "Zara", "initials": "Z"}, {"family": "Gianfrancesco", "given": "Milena A", "initials": "MA", "orcid": "0000-0002-8351-4626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dca9cada1314065ab094be6fc17524e.json"}}, {"family": "Carrara", "given": "Greta", "initials": "G"}, {"family": "Scir\u00e8", "given": "Carlo Alberto", "initials": "CA", "orcid": "0000-0001-7451-0271", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76ebc6c1acb94b2780a38dc4e8aea708.json"}}, {"family": "Zanetti", "given": "Anna", "initials": "A"}, {"family": "Machado", "given": "Pedro M", "initials": "PM", "orcid": "0000-0002-8411-7972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef40d1eea57946e4a37d2e92a02a47cd.json"}}], "type": "journal article", "published": "2023-08-29", "journal": {"title": "Arthritis Care Res (Hoboken)", "issn": "2151-4658", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Approximately one-third of individuals worldwide have not received a COVID-19 vaccine. While studies have investigated risk factors linked to severe COVID-19 among unvaccinated people with rheumatic diseases(RD), we know less about whether these factors changed as the pandemic progressed. We aimed to identify risk factors associated with severe COVID-19 in unvaccinated individuals in different pandemic epochs corresponding to major variants of concern.\r\n\r\nPatients with RD and COVID-19 were entered into the COVID-19 Global Rheumatology Alliance registry between March 2020 and June 2022. An ordinal logistic regression model (not hospitalized, hospitalized, and death) was used with date of COVID-19 diagnosis, age, sex, race and/or ethnicity, comorbidities, RD activity, medications, and the human development index(HDI) as covariates. The main analysis included all unvaccinated patients across COVID-19 pandemic epochs; sub-analyses stratified patients according to rheumatic disease types.\r\n\r\nAmong 19,256 unvaccinated people with RD and COVID-19, those who were older, male, had more comorbidities, used glucocorticoids, had higher disease activity, or lived in lower HDI regions had worse outcomes across epochs. For those with rheumatoid arthritis, sulfasalazine and B-cell depleting therapy were associated with worse outcomes, and TNF-inhibitors were associated with improved outcomes. In those with connective tissue disease or vasculitis, B-cell depleting therapy was associated with worse outcomes.\r\n\r\nRisk factors for severe COVID-19 outcomes were similar throughout pandemic epochs in unvaccinated people with RD. Ongoing efforts, including vaccination, are needed to reduce COVID-19 severity in this population, particularly in those with medical and social vulnerabilities identified in this study. This article is protected by copyright. All rights reserved.", "doi": "10.1002/acr.25220", "pmid": "37643903", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:08:47.001Z", "modified": "2023-10-06T04:36:31.468Z"}, {"entity": "publication", "iuid": "2c3ccb5cc8be45aebd39a89e3bf7627c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c3ccb5cc8be45aebd39a89e3bf7627c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c3ccb5cc8be45aebd39a89e3bf7627c"}}, "title": "Alterations in the gut microbiome and its metabolites are associated with the immune response to mucosal immunization with Lactiplantibacillus plantarum-displaying recombinant SARS-CoV-2 spike epitopes in mice.", "authors": [{"family": "Hwang", "given": "In-Chan", "initials": "I"}, {"family": "Vasquez", "given": "Robie", "initials": "R"}, {"family": "Song", "given": "Ji Hoon", "initials": "JH"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Valeriano", "given": "Valerie Diane", "initials": "VD"}, {"family": "Kang", "given": "Dae-Kyung", "initials": "D"}], "type": "journal article", "published": "2023-08-29", "journal": {"title": "Front Cell Infect Microbiol", "issn": "2235-2988", "issn-l": null, "volume": "13", "issue": null, "pages": "1242681"}, "abstract": "Lactic acid bacteria (LAB) expressing foreign antigens have great potential as mucosal vaccines. Our previous study reported that recombinant Lactiplantibacillus plantarum SK156 displaying SARS-CoV-2 spike S1 epitopes elicited humoral and cell-mediated immune responses in mice. Here, we further examined the effect of the LAB-based mucosal vaccine on gut microbiome composition and function, and gut microbiota-derived metabolites. Forty-nine (49) female BALB/c mice were orally administered L. plantarum SK156-displaying SARS-CoV-2 spike S1 epitopes thrice (at 14-day intervals). Mucosal immunization considerably altered the gut microbiome of mice by enriching the abundance of beneficial gut bacteria, such as Muribaculaceae, Mucispirillum, Ruminococcaceae, Alistipes, Roseburia, and Clostridia vadinBB60. Moreover, the predicted function of the gut microbiome showed increased metabolic pathways for amino acids, energy, carbohydrates, cofactors, and vitamins. The fecal concentration of short-chain fatty acids, especially butyrate, was also altered by mucosal immunization. Notably, alterations in gut microbiome composition, function, and butyrate levels were positively associated with the immune response to the vaccine. Our results suggest that the gut microbiome and its metabolites may have influenced the immunogenicity of the LAB-based SARS-CoV-2 vaccine.", "doi": "10.3389/fcimb.2023.1242681", "pmid": "37705931", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10495993"}], "notes": [], "created": "2023-10-06T06:57:13.128Z", "modified": "2023-10-09T06:22:09.264Z"}, {"entity": "publication", "iuid": "acab9062e3cb4dd9b5570dcc70e685b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/acab9062e3cb4dd9b5570dcc70e685b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/acab9062e3cb4dd9b5570dcc70e685b3"}}, "title": "Quality of life of COVID-19 recovered patients: a 1-year follow-up study from Bangladesh.", "authors": [{"family": "Hawlader", "given": "Mohammad Delwer Hossain", "initials": "MDH"}, {"family": "Rashid", "given": "Md Utba", "initials": "MU"}, {"family": "Khan", "given": "Md Abdullah Saeed", "initials": "MAS"}, {"family": "Liza", "given": "Mowshomi Mannan", "initials": "MM"}, {"family": "Akter", "given": "Sharmin", "initials": "S"}, {"family": "Hossain", "given": "Mohammad Ali", "initials": "MA"}, {"family": "Rahman", "given": "Tajrin", "initials": "T"}, {"family": "Barsha", "given": "Sabrina Yesmin", "initials": "SY"}, {"family": "Shifat", "given": "Alberi Afifa", "initials": "AA"}, {"family": "Hossian", "given": "Mosharop", "initials": "M"}, {"family": "Mishu", "given": "Tahmina Zerin", "initials": "TZ"}, {"family": "Sagar", "given": "Soumik Kha", "initials": "SK"}, {"family": "Manna", "given": "Ridwana Maher", "initials": "RM"}, {"family": "Ahmed", "given": "Nawshin", "initials": "N"}, {"family": "Debu", "given": "Sree Shib Shankar Devnath", "initials": "SSSD"}, {"family": "Chowdhury", "given": "Irin", "initials": "I"}, {"family": "Sabed", "given": "Samanta", "initials": "S"}, {"family": "Ahmed", "given": "Mashrur", "initials": "M"}, {"family": "Borsha", "given": "Sabrina Afroz", "initials": "SA"}, {"family": "Al Zafar", "given": "Faraz", "initials": "F"}, {"family": "Hyder", "given": "Sabiha", "initials": "S"}, {"family": "Enam", "given": "Abdullah", "initials": "A"}, {"family": "Babul", "given": "Habiba", "initials": "H"}, {"family": "Nur", "given": "Naima", "initials": "N"}, {"family": "Haque", "given": "Miah Md Akiful", "initials": "MMA"}, {"family": "Roy", "given": "Shopnil", "initials": "S"}, {"family": "Tanvir Hassan", "given": "K M", "initials": "KM"}, {"family": "Rahman", "given": "Mohammad Lutfor", "initials": "ML"}, {"family": "Nabi", "given": "Mohammad Hayatun", "initials": "MH"}, {"family": "Dalal", "given": "Koustuv", "initials": "K", "orcid": "0000-0001-7393-796X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab5e44a17b7545988cb46cdf5b1f3e4e.json"}}], "type": "journal article", "published": "2023-08-25", "journal": {"title": "Infect Dis Poverty", "issn": "2049-9957", "issn-l": null, "volume": "12", "issue": "1", "pages": "79"}, "abstract": "The COVID-19 pandemic posed a danger to global public health because of the unprecedented physical, mental, social, and environmental impact affecting quality of life (QoL). The study aimed to find the changes in QoL among COVID-19 recovered individuals and explore the determinants of change more than 1 year after recovery in low-resource settings.\r\n\r\nCOVID-19 patients from all eight divisions of Bangladesh who were confirmed positive by reverse transcription-polymerase chain reaction from June 2020 to November 2020 and who subsequently recovered were followed up twice, once immediately after recovery and again 1 year after the first follow-up. The follow-up study was conducted from November 2021 to January 2022 among 2438 individuals using the World Health Organization Quality of Life Brief Version (WHOQOL-BREF). After excluding 48 deaths, 95 were rejected to participate, 618 were inaccessible, and there were 45 cases of incomplete data. Descriptive statistics, paired-sample analyses, generalized estimating equation (GEE) analysis, and multivariable logistic regression analyses were performed to test the mean difference in participants' QoL scores between the two interviews.\r\n\r\nMost participants (n = 1710, 70.1%) were male, and one-fourth (24.4%) were older than 46. The average physical domain score decreased significantly from baseline to follow-up, and the average scores in psychological, social, and environmental domains increased significantly at follow-up (P < 0.05). By the GEE equation approach, after adjusting for other factors, we found that older age groups (P < 0.001), being female (P < 0.001), having hospital admission during COVID-19 illness (P < 0.001), and having three or more chronic diseases (P < 0.001), were significantly associated with lower physical and psychological QoL scores. Higher age and female sex [adjusted odd ratio (aOR) = 1.3, 95% confidence interval (CI) 1.0-1.6] were associated with reduced social domain scores on multivariable logistic regression analysis. Urban or semi-urban people were 49% less likely (aOR = 0.5, 95% CI 0.4-0.7) and 32% less likely (aOR = 0.7, 95% CI 0.5-0.9) to have a reduced QoL score in the psychological domain and the social domain respectively, than rural people. Higher-income people were more likely to experience a decrease in QoL scores in physical, psychological, social, and environmental domains. Married people were 1.8 times more likely (aOR = 1.8, 95% CI 1.3-2.4) to have a decreased social QoL score. In the second interview, people admitted to hospitals during their COVID-19 infection showed a 1.3 times higher chance (aOR = 1.3, 95% CI 1.1-1.6) of a decreased environmental QoL score. Almost 13% of participants developed one or more chronic diseases between the first and second interviews. Moreover, 7.9% suffered from reinfection by COVID-19 during this 1-year time.\r\n\r\nThe present study found that the QoL of COVID-19 recovered people improved 1 year after recovery, particularly in psychological, social, and environmental domains. However, age, sex, the severity of COVID-19, smoking habits, and comorbidities were significantly negatively associated with QoL. Events of reinfection and the emergence of chronic disease were independent determinants of the decline in QoL scores in psychological, social, and physical domains, respectively. Strong policies to prevent and minimize smoking must be implemented in Bangladesh, and we must monitor and manage chronic diseases in people who have recovered from COVID-19.", "doi": "10.1186/s40249-023-01125-9", "pmid": "37626363", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10463646"}, {"db": "pii", "key": "10.1186/s40249-023-01125-9"}], "notes": [], "created": "2023-10-05T08:08:51.924Z", "modified": "2023-10-06T04:39:17.151Z"}, {"entity": "publication", "iuid": "ae50d23c447b4196954c31aa1bdc0fb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ae50d23c447b4196954c31aa1bdc0fb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ae50d23c447b4196954c31aa1bdc0fb1"}}, "title": "Bayesian monitoring of COVID-19 in Sweden.", "authors": [{"family": "Marin", "given": "Robin", "initials": "R"}, {"family": "Runvik", "given": "H\u00e5kan", "initials": "H"}, {"family": "Medvedev", "given": "Alexander", "initials": "A"}, {"family": "Engblom", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2023-08-24", "journal": {"title": "Epidemics", "issn": "1878-0067", "issn-l": null, "volume": "45", "issue": null, "pages": "100715"}, "abstract": "In an effort to provide regional decision support for the public healthcare, we design a data-driven compartment-based model of COVID-19 in Sweden. From national hospital statistics we derive parameter priors, and we develop linear filtering techniques to drive the simulations given data in the form of daily healthcare demands. We additionally propose a posterior marginal estimator which provides for an improved temporal resolution of the reproduction number estimate as well as supports robustness checks via a parametric bootstrap procedure. From our computational approach we obtain a Bayesian model of predictive value which provides important insight into the progression of the disease, including estimates of the effective reproduction number, the infection fatality rate, and the regional-level immunity. We successfully validate our posterior model against several different sources, including outputs from extensive screening programs. Since our required data in comparison is easy and non-sensitive to collect, we argue that our approach is particularly promising as a tool to support monitoring and decisions within public health. Significance: Using public data from Swedish patient registries we develop a national-scale computational model of COVID-19. The parametrized model produces valuable weekly predictions of healthcare demands at the regional level and validates well against several different sources. We also obtain critical epidemiological insights into the disease progression, including, e.g., reproduction number, immunity and disease fatality estimates. The success of the model hinges on our novel use of filtering techniques which allows us to design an accurate data-driven procedure using data exclusively from healthcare demands, i.e., our approach does not rely on public testing and is therefore very cost-effective.", "doi": "10.1016/j.epidem.2023.100715", "pmid": "37703786", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Other": null, "Funder: Vinnova": null}, "xrefs": [{"db": "pii", "key": "S1755-4365(23)00051-8"}], "notes": [], "created": "2023-10-04T12:10:33.906Z", "modified": "2023-10-06T11:35:30.320Z"}, {"entity": "publication", "iuid": "1f0f46e03164417b85380701e798b5a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1f0f46e03164417b85380701e798b5a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1f0f46e03164417b85380701e798b5a9"}}, "title": "Efficacy of Kan Jang\u00ae in Patients with Mild COVID-19: A Randomized, Quadruple-Blind, Placebo-Controlled Trial.", "authors": [{"family": "Ratiani", "given": "Levan", "initials": "L"}, {"family": "Pachkoria", "given": "Elene", "initials": "E"}, {"family": "Mamageishvili", "given": "Nato", "initials": "N"}, {"family": "Shengelia", "given": "Ramaz", "initials": "R"}, {"family": "Hovhannisyan", "given": "Areg", "initials": "A"}, {"family": "Panossian", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8467-4525", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86a40ce1842b4c289c7f09c955ad4325.json"}}], "type": "journal article", "published": "2023-08-22", "journal": {"title": "Pharmaceuticals (Basel)", "issn": "1424-8247", "issn-l": null, "volume": "16", "issue": "9", "pages": null}, "abstract": ". This study aimed to assess the efficacy of the treatment of Kan JangBackground and aim\u00ae, a fixed combination of Andrographis paniculata (Burm. F.) Wall. ex. Nees and Eleutherococcus senticosus (Rupr. & Maxim.) Maxim extracts in patients with mild symptoms of COVID-19. . One hundred and forty patients received six capsules of Kan JangMethods\u00ae (n = 68, daily dose of andrographolides-90 mg) or placebo (n = 72) and supportive treatment (paracetamol) for 14 consecutive days in a randomized, quadruple-blinded, placebo-controlled, two-parallel-group design. The efficacy outcomes were the rate of cases turning to severe, the detection rate of coronavirus SARS-CoV-2 over the time of treatment, the duration, and the severity of symptoms (sore throat, runny nose, cough, headache, fatigue, loss of smell, taste, pain in muscles) in the acute phase of the disease. Other efficacy measures included improving cognitive and physical performance, quality of life, and the levels of inflammatory blood markers-interleukin 6 (IL-6), C-reactive protein, and D-dimer. . Kan JangResults\u00ae significantly (p < 0.05) reduced the rate of cases turning to severe (5.36%) compared to the placebo (17.86%) and decreased the detection rate of SARS-CoV-2 virus over the time of the treatment. The statistical difference in the rates of patients with clinical deterioration in the Kan Jang treatment and placebo control groups was significant (p = 0.0176) both in the 112 patients in the included-per-protocol (IPP) analysis and in the 140 patients in the intended-to-treat (ITT) analysis (p = 0.0236); the absolute risk reduction in cases thanks to the Kan Jang treatment was 12.5%, and the number we needed to treat with Kan Jang was 8. The patient's recovery time (number of sick days at the home/clinic) was shorter in the Kan Jang group compared with the placebo group. The rate of attenuation of inflammatory symptoms in the Kan Jang\u00ae group was significantly higher, decreasing the severity of cough, sore throat/pain, runny nose, and muscle soreness compared with the placebo group. Kan Jang\u00ae significantly decreased the Wisconsin Upper Respiratory Symptoms scores compared to the placebo in the sample size of 140 patients. However, the relief of fatigue and headache and the decrease in IL-6 in the blood were observed only in a subset of 86 patients infected during the second three waves of the pandemic. Kan Jang\u00ae significantly increased physical activity and workout; however, it did not affect cognitive functions (attention and memory), quality of life score, inflammatory marker D-dimer, and C-reactive protein compared with the placebo group. . Overall, the results of this study suggest that Kan JangConclusions\u00ae is effective in treating mild and moderate COVID-19 irrespective of the SARS-CoV-2 variant of infection.", "doi": "10.3390/ph16091196", "pmid": "37765004", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10535596"}, {"db": "pii", "key": "ph16091196"}], "notes": [], "created": "2023-10-06T06:55:26.233Z", "modified": "2023-10-06T10:53:37.475Z"}, {"entity": "publication", "iuid": "24216cd75b2047d8a66e2d97d42d7563", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24216cd75b2047d8a66e2d97d42d7563.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24216cd75b2047d8a66e2d97d42d7563"}}, "title": "Person-centred care in nursing homes during the COVID-19 pandemic: a cross sectional study based on nursing staff and first-line managers' self-reported outcomes.", "authors": [{"family": "Lindner", "given": "Helen", "initials": "H"}, {"family": "Kihlgren", "given": "Annica", "initials": "A"}, {"family": "Pejner", "given": "Margaretha Norell", "initials": "MN"}], "type": "journal article", "published": "2023-08-21", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "issn-l": null, "volume": "22", "issue": "1", "pages": "276"}, "abstract": "COVID-19 has presented many difficulties in providing person-centred care (PCC) in nursing homes (NH). Factors such as organisational support, work condition and leadership may play a crucial role in supporting the performance of PCC during COVID restrictions. The study aim was to evaluate nursing staff and manager perceptions of the opportunities to perform person-centred care during the COVID-19 pandemic.\r\n\r\nNursing staff (NS) (n = 463) and First Line Managers (FLM) (n = 8) within all NHs in one community filled in the SVENIS questionnaire which consists of five areas: perceived organizational support, work climate, person-centred care, work conditions and leadership. A Kruskal-Wallis test was used to perform inter-group comparisons and standard multiple regression was used to investigate which factor contributed most to perform PCC.\r\n\r\nThe comparison analyses indicate that staff from nursing homes for persons with dementia had the highest opportunities to perform PCC during the pandemic. The day shift staff had more opportunities to perform PCC than night shift staff. The results from the standard multiple regression show that a NA's current nursing home was the most significant variable affecting the opportunities to perform PCC. The analyses of both the comparison analyses and the regression suggest that day shift staff from nursing homes for persons with dementia had the highest opportunities to perform PCC during the pandemic. The same group also rated the importance of leadership as high for performing PCC.\r\n\r\nDespite the COVID-19 restrictions and all the criticism directed against the care of older people; the day staff felt that they conducted PCC. Staff in nursing homes for dementia had the highest opportunities for PCC and this may be because they are better prepared to provide care for the individual in NH. The importance of leadership was also evident, which means that investment in FLMs is seen as necessary.", "doi": "10.1186/s12912-023-01437-z", "pmid": "37605177", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10440872"}, {"db": "pii", "key": "10.1186/s12912-023-01437-z"}], "notes": [], "created": "2023-10-05T08:08:54.351Z", "modified": "2023-10-06T04:40:25.696Z"}, {"entity": "publication", "iuid": "7ca4bd5cc52d4aed97bf6158b63fc396", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7ca4bd5cc52d4aed97bf6158b63fc396.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7ca4bd5cc52d4aed97bf6158b63fc396"}}, "title": "Early Onset Delirium During Hospitalization Increases In-Hospital and Postdischarge Mortality in COVID-19 Patients: A Multicenter Prospective Study.", "authors": [{"family": "Trevisan", "given": "Caterina", "initials": "C"}, {"family": "Grande", "given": "Giulia", "initials": "G"}, {"family": "Rebora", "given": "Paola", "initials": "P"}, {"family": "Zucchelli", "given": "Alberto", "initials": "A"}, {"family": "Valsecchi", "given": "Maria Grazia", "initials": "MG"}, {"family": "Foc\u00e0", "given": "Emanuele", "initials": "E"}, {"family": "Ecarnot", "given": "Fiona", "initials": "F"}, {"family": "Marengoni", "given": "Alessandra", "initials": "A"}, {"family": "Bellelli", "given": "Giuseppe", "initials": "G"}], "type": "multicenter study", "published": "2023-08-21", "journal": {"title": "J Clin Psychiatry", "issn": "1555-2101", "issn-l": null, "volume": "84", "issue": "5", "pages": null}, "abstract": "Delirium is a common feature in COVID-19 patients. Although its association with in-hospital mortality has previously been reported, data concerning postdischarge mortality and delirium subtypes are scarce. We evaluated the association between delirium and its subtypes and both in-hospital and postdischarge mortality. Objective: This multicenter longitudinal clinical-based study was conducted in Monza and Brescia, Italy. The study population included 1,324 patients (median age: 68 years) with COVID-19 admitted to 4 acute clinical wards in northern Italy during the first pandemic waves (February 2020 to January 2021). Delirium within 48 hours of hospital admission was assessed through validated scores and/or clinically according to Methods:DSM-5 criteria. The association of delirium-and its subtypes-with in-hospital and postdischarge mortality (over a median observation period of 257 [interquartile range: 189-410] days) was evaluated through Cox proportional hazards models. The 223 patients (16.8%) presenting delirium had around 2-fold increased in-hospital (hazard ratio [HR] = 1.94; 95% CI, 1.38-2.73) and postdischarge (HR = 2.01; 95% CI, 1.48-2.73) mortality than those without delirium. All delirium subtypes were associated with greater risk of death compared to the absence of delirium, but hypoactive delirium revealed the strongest associations with both in-hospital (HR = 2.03; 95% CI, 1.32-3.13) and postdischarge (HR = 2.22; 95% CI, 1.52-3.26) mortality. Results: In patients with COVID-19, early onset delirium is associated not only with in-hospital mortality but also with shorter postdischarge survival. This suggests that delirium detection and management are crucial to improving the prognosis of COVID-19 patients. Conclusions: ClinicalTrials.gov identifier: NCT04412265.Trial Registration:", "doi": "10.4088/JCP.22m14565", "pmid": "37616485", "labels": {"Category: Health": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "22m14565"}, {"db": "ClinicalTrials.gov", "key": "NCT04412265"}], "notes": [], "created": "2023-10-05T08:26:04.491Z", "modified": "2023-10-06T04:45:08.102Z"}, {"entity": "publication", "iuid": "ec5bd7a61fa74750ba0036e4f5db58e4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec5bd7a61fa74750ba0036e4f5db58e4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec5bd7a61fa74750ba0036e4f5db58e4"}}, "title": "Did the COVID-19 pandemic influence inequality in self-reported work environment conditions based on gender and place of birth? A study of a Swedish commercial laundromat.", "authors": [{"family": "Januario", "given": "Leticia Bergamin", "initials": "LB"}, {"family": "Mathiassen", "given": "Svend Erik", "initials": "SE"}, {"family": "Bergstr\u00f6m", "given": "Gunnar", "initials": "G"}, {"family": "Jackson", "given": "Jennie A", "initials": "JA"}], "type": "journal article", "published": "2023-08-21", "journal": {"title": "Appl Ergon", "issn": "1872-9126", "issn-l": null, "volume": "114", "issue": null, "pages": "104113"}, "abstract": "We evaluated differences in work environment conditions and health by gender and place of birth in a commercial laundromat prior to (baseline) and at the end of the first wave of the COVID-19 pandemic (follow-up). Using survey data, including dimensions from the Copenhagen Psychosocial Questionnaire, from forty-one workers, we assessed work environment conditions and health at baseline, follow-up and in change scores between baseline and follow-up. At baseline, men and women reported similar scores, while foreign-born (FB) workers reported better work environment conditions than Swedish-born (SB) workers. During the pandemic, conditions generally declined for all workers, but FB reported smaller declines than SB. A consistent inequality hierarchy across the 4 groups was not clear at baseline, follow-up or in change scores between time points. The study suggests potential cultural differences may exist in how work environment conditions are experienced. This should be considered in future studies and when managing future crises.", "doi": "10.1016/j.apergo.2023.104113", "pmid": "37611535", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0003-6870(23)00151-5"}], "notes": [], "created": "2023-10-05T08:26:35.912Z", "modified": "2023-10-06T05:00:50.941Z"}, {"entity": "publication", "iuid": "3aac4306641a4a01bb31154e6c7616cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3aac4306641a4a01bb31154e6c7616cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3aac4306641a4a01bb31154e6c7616cb"}}, "title": "Two cases of nursing older nursing home residents during COVID-19.", "authors": [{"family": "Jaarsma", "given": "Pier", "initials": "P", "orcid": "0000-0003-4429-2853", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91b16416951a4b2a831961d5e9a7a6d1.json"}}, {"family": "Gelhaus", "given": "Petra", "initials": "P"}, {"family": "Eklund Saksberg", "given": "My", "initials": "M"}], "type": "journal article", "published": "2023-08-19", "journal": {"title": "Nurs Ethics", "issn": "1477-0989", "issn-l": null, "volume": null, "issue": null, "pages": "9697330231185944"}, "abstract": "Two ethical challenges of nursing home nurses during the COVID-19 pandemic in Sweden are discussed in this paper.\r\n\r\nHistorically, the nurse's primary concern is for the person who is ill, which is the core of nurses' moral responsibility and identity. In Sweden, person-centered care is generally deemed important in nursing older nursing home residents.\r\n\r\nTo chart moral responsibilities of nursing home nurses in two cases involving older residents during the COVID-19 pandemic in Sweden.\r\n\r\nWe used Margaret Urban Walker's framework for moral responsibilities and the International Council of Nurses (ICN) code of ethics for nurses (2021) for our normative analysis.\r\n\r\nWritten and verbal consent was obtained before the interviews, and information was given that participation was entirely voluntary and possible to cancel at any time before the work was published. The Swedish Ethical Review Agency gave an advisory opinion stating that there were no ethical objections to this research project (Dnr. 2020-05649).\r\n\r\nCase #1: a palliative older nursing home resident who was coercively tested for COVID-19, and case #2: a COVID-19-infected resident with dementia who was isolated using sedation. The decision that was finally made in the respective case was analyzed in the light of either consequentialist/utilitarian or non-consequentialist/deontological reasons.\r\n\r\nEmpowerment of nurses as moral agents is required for the application of practical wisdom in the balancing of different care relationships (responsibilities), moral identities (professional virtues), and competing moral values. This requires resources and opens possibilities for profound ethical reflection in nursing education and at work.\r\n\r\nDuring the COVID-19 pandemic, the moral and professional responsibility of nursing home nurses to deliver person-centered care was sometimes problematically abandoned in favor of a more utilitarian manner of ethical decision-making.", "doi": "10.1177/09697330231185944", "pmid": "37597000", "labels": {"Funder: Forte": null, "Type: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:08:37.400Z", "modified": "2023-10-05T08:55:22.474Z"}, {"entity": "publication", "iuid": "4ed3677531104d9392850a68bffd903f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ed3677531104d9392850a68bffd903f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ed3677531104d9392850a68bffd903f"}}, "title": "Risk and outcomes of COVID-19 in patients with oxygen-dependent chronic respiratory failure- a national cohort study.", "authors": [{"family": "Sundh", "given": "Josefin", "initials": "J"}, {"family": "Palm", "given": "Andreas", "initials": "A"}, {"family": "Ljunggren", "given": "Mirjam", "initials": "M"}, {"family": "Emilsson", "given": "\u00d6ssur Ingi", "initials": "\u00d6I"}, {"family": "Grote", "given": "Ludger", "initials": "L"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ekstr\u00f6m", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2023-08-19", "journal": {"title": "Respir Med", "issn": "1532-3064", "issn-l": "0954-6111", "volume": "218", "issue": null, "pages": "107392"}, "abstract": "We aimed to evaluate cumulative occurrence and impact of COVID-19 in patients with chronic respiratory failure (CRF) treated with long-term oxygen therapy (LTOT).\r\n\r\nData were obtained from the SCIFI-PEARL study on the entire Swedish population and on patients with oxygen-dependent CRF and no COVID-19 diagnosis before start of LTOT. Analyses were performed for three time periods; pre-alpha (Jan-Dec 2020), alpha (Jan-Mar 2021) and delta/omicron (Apr 2021-May 2022). Cumulative incidence of laboratory-verified COVID-19 was compared between patients with CRF and the general population. Risk factors for severe (hospitalised) to critical (intensive care, or death \u226430 days after infection) COVID-19, and the impact of COVID-19 on one-year mortality, were analysed using multivariable Cox regression.\r\n\r\nCumulative incidence of COVID-19 was higher in patients with CRF than in the general population during the pre-alpha period (6.4%/4.9%, p = 0.002), but less common during the alpha and delta/omicron periods (2.9%/3.8% and 7.8%/15.5%, p < 0.0001 for both). The risk of severe/critical COVID-19 was much higher in CRF patients during all periods (4.9%/0.5%, 3.8%/0.2% and 15.5%/0.5%, p < 0.0001 for all). Risk factors for COVID-19 infection in people with CRF were higher age, cardiovascular and renal disease, and COVID-19 was associated with increased one-year mortality following infection in the pre-alpha (HR 1.79; [95% CI] 1.27-2.53) and alpha periods (1.43; 1.03-1.99).\r\n\r\nPatients with CRF had higher risk of severe/critical COVID-19 than the general population. COVID-19 infection was associated with excess one-year mortality.", "doi": "10.1016/j.rmed.2023.107392", "pmid": "37598894", "labels": {"Category: Health": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pii", "key": "S0954-6111(23)00280-9"}], "notes": [], "created": "2023-10-05T08:02:26.196Z", "modified": "2023-10-05T08:42:32.803Z"}, {"entity": "publication", "iuid": "3e633c6a7f7043679e7d6028c9f85f40", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3e633c6a7f7043679e7d6028c9f85f40.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3e633c6a7f7043679e7d6028c9f85f40"}}, "title": "Variations across Europe in hospitalization and management of pregnant women with SARS-CoV-2 during the initial phase of the pandemic: Multi-national population-based cohort study using the International Network of Obstetric Survey Systems (INOSS).", "authors": [{"family": "de Bruin", "given": "Odette", "initials": "O", "orcid": "0000-0001-6295-3411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cb1846613dd40b0a620d3b57bdf7012.json"}}, {"family": "Engjom", "given": "Hilde", "initials": "H", "orcid": "0000-0003-1582-4283", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c252a103177f4a12a560a5fa1a02941a.json"}}, {"family": "Vousden", "given": "Nicola", "initials": "N"}, {"family": "Ramakrishnan", "given": "Rema", "initials": "R"}, {"family": "Aabakke", "given": "Anna J M", "initials": "AJM", "orcid": "0000-0003-4754-506X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c142bd2b1fc84a7e864d2af58096bcaf.json"}}, {"family": "\u00c4yr\u00e4s", "given": "Outi", "initials": "O", "orcid": "0000-0002-2423-611X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45245d469a6a4629bb3197f51be274bf.json"}}, {"family": "Donati", "given": "Serena", "initials": "S", "orcid": "0000-0002-4607-2072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52c96021dc5f4d41a7098cd3b5815649.json"}}, {"family": "J\u00f3nasd\u00f3ttir", "given": "Eva", "initials": "E"}, {"family": "Knight", "given": "Marian", "initials": "M", "orcid": "0000-0002-1984-4575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c2039d5a7904bb2b86fcc9288b1c4fa.json"}}, {"family": "Overtoom", "given": "Evelien M", "initials": "EM", "orcid": "0000-0001-6454-4531", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd001d702fe0494ebe68a0d0b4dae739.json"}}, {"family": "Salvatore", "given": "Michele A", "initials": "MA"}, {"family": "Sturkenboom", "given": "Miriam C J M", "initials": "MCJM"}, {"family": "Svanvik", "given": "Teresia", "initials": "T", "orcid": "0000-0003-1947-679X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5c912ccb32524c468a81dd35f17f10cb.json"}}, {"family": "Varpula", "given": "Reetta", "initials": "R"}, {"family": "Vercoutere", "given": "An", "initials": "A"}, {"family": "Bloemenkamp", "given": "Kitty W M", "initials": "KWM", "orcid": "0000-0002-1377-4625", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6fc16703b53043369e998576c3e74737.json"}}, {"family": "INOSS COVID-19 Working Group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-08-18", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "issn-l": "0001-6349", "volume": null, "issue": null, "pages": null}, "abstract": "The majority of data on COVID-19 in pregnancy are not from sound population-based active surveillance systems.\r\n\r\nWe conducted a multi-national study of population-based national or regional prospective cohorts using standardized definitions within the International Network of Obstetric Survey systems (INOSS). From a source population of women giving birth between March 1 and August 31, 2020, we included pregnant women admitted to hospital with a positive SARS-CoV-2 PCR test \u22647 days prior to or during admission and up to 2 days after birth. The admissions were further categorized as COVID-19-related or non-COVID-19-related. The primary outcome of interest was incidence of COVID-19-related hospital admission. Secondary outcomes included severe maternal disease (ICU admission and mechanical ventilation) and COVID-19-directed medical treatment.\r\n\r\nIn a source population of 816 628 maternities, a total of 2338 pregnant women were admitted with SARS-CoV-2; among them 940 (40%) were COVID-19-related admissions. The pooled incidence estimate for COVID-19-related admission was 0.59 (95% confidence interval 0.27-1.02) per 1000 maternities, with notable heterogeneity across countries (I2 = 97.3%, P = 0.00). In the COVID-19 admission group, between 8% and 17% of the women were admitted to intensive care, and 5%-13% needed mechanical ventilation. Thromboprophylaxis was the most frequent treatment given during COVID-19-related admission (range 14%-55%). Among 908 infants born to women in the COVID-19-related admission group, 5 (0.6%) stillbirths were reported.\r\n\r\nDuring the initial months of the pandemic, we found substantial variations in incidence of COVID-19-related admissions in nine European countries. Few pregnant women received COVID-19-directed medical treatment. Several barriers to rapid surveillance were identified. Investment in robust surveillance should be prioritized to prepare for future pandemics.", "doi": "10.1111/aogs.14643", "pmid": "37594175", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:01:41.758Z", "modified": "2023-10-05T08:31:24.775Z"}, {"entity": "publication", "iuid": "fd298155e85d4de1bf6e8e9532a22e63", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fd298155e85d4de1bf6e8e9532a22e63.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fd298155e85d4de1bf6e8e9532a22e63"}}, "title": "Hospital Admission Rates in Patients with COPD Throughout the COVID-19 Pandemic.", "authors": [{"family": "Andreen", "given": "Niklas", "initials": "N", "orcid": "0000-0002-7349-3120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/112f52ac7eb84986ba16b220903beb5f.json"}}, {"family": "Westin", "given": "Johan", "initials": "J"}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW", "orcid": "0000-0002-4387-4096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bb5d1f761ef48c4837ed4f984717f0e.json"}}], "type": "journal article", "published": "2023-08-17", "journal": {"title": "Int J Chron Obstruct Pulmon Dis", "issn": "1178-2005", "issn-l": null, "volume": "18", "issue": null, "pages": "1763-1772"}, "abstract": "Several studies report decreased hospital admissions for acute exacerbations of COPD (AECOPD) during the COVID-19 pandemic. However, there are no studies that compare AECOPD admissions with admissions for respiratory infections, including COVID-19. This study aimed to examine hospital admission rates for AECOPD, pneumonia, influenza, and COVID-19 among COPD patients, before and during the COVID-19 pandemic.\r\n\r\nWe obtained anonymized data on hospital admissions of patients with COPD and a primary diagnosis code for AECOPD, pneumonia, influenza, or COVID-19, from the hospital patient admission register at a large Swedish hospital. The study compared the pandemic period (February 2020-March 2022) to a period before the pandemic (June 2017-January 2020). Sequential phases of the pandemic were evaluated separately. Monthly admission rates were compared using Poisson regression, controlling for admission month.\r\n\r\nComparing monthly admission rates during the pandemic with the prepandemic period, incidence rate ratios were 0.72 for AECOPD (95% CI 0.67-0.77; p<0.001), 0.56 for pneumonia (95% CI 0.49-0.62; p<0.001), 0.18 for influenza during the winter period (95% CI 0.10-0.30; p<0.001) and 0.79 for total COPD admissions, including COVID-19 (95% CI 0.75-0.84; p<0.001). The study showed significantly lower rate ratios for AECOPD, pneumonia, and total COPD admissions during the first, second, third, and fifth (Omicron) waves. No significant effect on admissions was seen after the withdrawal of restriction measures.\r\n\r\nThere was a significant reduction in the overall rate of hospital admissions among COPD patients for AECOPD, pneumonia, and respiratory viral infections during the pandemic despite the rise in COVID-19 admissions. However, prepandemic admission levels returned in the post-restriction period.", "doi": "10.2147/COPD.S409452", "pmid": "37608833", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC10441640"}, {"db": "pii", "key": "409452"}], "notes": [], "created": "2023-10-05T08:02:43.676Z", "modified": "2023-10-05T08:51:00.004Z"}, {"entity": "publication", "iuid": "b8666e1363444f6787a65e606a5a9b78", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8666e1363444f6787a65e606a5a9b78.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8666e1363444f6787a65e606a5a9b78"}}, "title": "Pandemic stressors and mental health indicators in eight countries.", "authors": [{"family": "Abdalla", "given": "Salma M", "initials": "SM"}, {"family": "Koya", "given": "Shaffi Fazaludeen", "initials": "SF"}, {"family": "Rosenberg", "given": "Samuel B", "initials": "SB"}, {"family": "Stovall", "given": "Isaac B", "initials": "IB"}, {"family": "Biermann", "given": "Olivia", "initials": "O"}, {"family": "Zeinali", "given": "Zahra", "initials": "Z"}, {"family": "Cohen", "given": "Gregory H", "initials": "GH"}, {"family": "Ettman", "given": "Catherine K", "initials": "CK"}, {"family": "Galea", "given": "Sandro", "initials": "S"}], "type": "journal article", "published": "2023-08-16", "journal": {"title": "Soc Psychiatry Psychiatr Epidemiol", "issn": "1433-9285", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The Covid-19 pandemic has exacted a significant physical, financial, social, and emotional toll on populations throughout the world. This study aimed to document the association between pandemic stressors and mental health during the pandemic across countries that differ in cultural, geographic, economic, and demographic factors.\r\n\r\nWe administered an online survey randomly in Brazil, China, Germany, Egypt, India, Indonesia, Nigeria, and the United States from September 2020 to November 2020. This survey included questions on Covid-19-related stressors as well as the Patient Health Questionnaire-2 and the Primary Care PTSD Checklist to screen for depression and post-traumatic stress disorder (PTSD) symptoms, respectively. We performed bivariable and multivariable regression analyses to assess the prevalence and odds ratios of overall depression symptoms and probable PTSD and in relation to stressors across countries.\r\n\r\nAmong 8754 respondents, 28.9% (95% CI 27.5-30.0%) experienced depression symptoms, and 5.1% (95% CI 4.5-6.0%) experienced probable PTSD. The highest prevalence of depression symptoms was in Egypt (41.3%, 95% CI 37.6-45.0%) and lowest in the United States (24.9%, 95% CI 22.3-27.7%). The highest prevalence of probable PTSD was in Brazil (7.3%, 95% CI 5.6-9.4%) and the lowest in China (1.2%, 95% CI 0.7-2.0%). Overall, experiencing six or more Covid-19-related stressors was associated with both depression symptoms (OR 1.90, 95% CI 1.46-2.48) and probable PTSD (OR 13.8, 95% CI 9.66-19.6).\r\n\r\nThe association between pandemic related stressors and the burden of adverse mental health indicators early in the Covid-19 pandemic transcended geographic, economic, cultural, and demographic differences between countries. The short-term and long-term impacts of the pandemic on mental health should be incorporated in efforts to tackle the consequences of Covid-19.", "doi": "10.1007/s00127-023-02541-w", "pmid": "37587229", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00127-023-02541-w"}], "notes": [], "created": "2023-10-05T08:08:56.769Z", "modified": "2023-10-06T04:41:31.399Z"}, {"entity": "publication", "iuid": "3a7396ea5aa8414ab1dbf4c1cb3eb871", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a7396ea5aa8414ab1dbf4c1cb3eb871.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a7396ea5aa8414ab1dbf4c1cb3eb871"}}, "title": "COVID-19 Restrictions Resulted in Both Positive and Negative Effects on Digital Media Use, Mental Health, and Lifestyle Habits.", "authors": [{"family": "Nutley", "given": "Sissela B", "initials": "SB", "orcid": "0000-0002-0676-0380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76343d4da98a4fa0b45ae8cd79ceb6ae.json"}}, {"family": "Bur\u00e9n", "given": "Jonas", "initials": "J"}, {"family": "Thorell", "given": "Lisa B", "initials": "LB", "orcid": "0000-0002-7417-6637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c947bd794d04fd492bca68071260ed5.json"}}], "type": "journal article", "published": "2023-08-16", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "20", "issue": "16", "pages": null}, "abstract": "While studies have reported effects on digital media during the COVID-19 restrictions, few have included data prior to the pandemic, and most have only measured screen time. We therefore investigated changes in specific digital media activities, as well as mental health and lifestyle habits, in a longitudinal study of adolescents spanning from before the pandemic (T1) to one month into restrictions (T2) and one year later when schools had reopened (T3). Adolescents (16-19 years) rated smartphone use, problematic/addictive media use, negative experiences (e.g., victimization), mental health (i.e., irritability, stress, and closeness), and protective lifestyle habits (i.e., sleep and exercise). Results showed initial decreases in irritability and negative digital experiences, increases in sleep and exercise, as well as a decrease in closeness during remote learning (T2). However, these changes returned to, or superseded, their initial levels at follow-up (T3). There were also increases in digital media use and stress at T3. Conclusively, by investigating specific digital media activities and collecting data both prior to and during different phases of the pandemic, we were able to find both positive and negative effects.", "doi": "10.3390/ijerph20166583", "pmid": "37623169", "labels": {"Type: Journal article": null, "Funder: Forte": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10454500"}, {"db": "pii", "key": "ijerph20166583"}], "notes": [], "created": "2023-10-05T08:26:48.574Z", "modified": "2023-10-06T05:06:46.288Z"}, {"entity": "publication", "iuid": "47f7b9fd9c1f4e7a85351dc2de766f48", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47f7b9fd9c1f4e7a85351dc2de766f48.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47f7b9fd9c1f4e7a85351dc2de766f48"}}, "title": "Nursing Students' Computer Anxiety and Attitudes Before and During the COVID-19 Pandemic.", "authors": [{"family": "Papathanasiou", "given": "Ioanna V", "initials": "IV"}, {"family": "Mantzaris", "given": "Dimitrios", "initials": "D"}, {"family": "Fradelos", "given": "Evangelos C", "initials": "EC"}, {"family": "Christodoulou", "given": "Nikolaos G", "initials": "NG"}, {"family": "Lee", "given": "Ka Yiu", "initials": "KY"}, {"family": "Tsaloglidou", "given": "Areti", "initials": "A"}, {"family": "Albani", "given": "Eleni", "initials": "E"}, {"family": "Malli", "given": "Foteini", "initials": "F"}, {"family": "Gourgoulianis", "given": "Konstantinos I", "initials": "KI"}], "type": "journal article", "published": "2023-08-15", "journal": {"title": "Adv Exp Med Biol", "issn": "0065-2598", "issn-l": null, "volume": "1425", "issue": null, "pages": "377-391"}, "abstract": "Purpose of this research was to investigate how the COVID-19 pandemic affected the level of computer anxiety of nursing students and also their attitude related to computer use. A cross-sectional study was conducted in two periods, one before the COVID-19 pandemic (1st period) and the second during the COVID-19 pandemic (2nd period). The research instrument consisted of three parts, a questionnaire with questions about demographic and educational characteristics such as gender and semester of study, the Computer Anxiety Rating Scale (CARS), that used to assess the nursing students' levels of computer anxiety and the Computer Attitude Scale (CAS) that used to measure nursing students' positive and negative attitudes towards computers. Data from 957 undergraduate nursing students were obtained. Specifically, in the 1st period, 370 nursing students participated (38.66%), while in the 2nd period 587 (61.34%) undergraduates participated. The anxiety of participants during COVID-19 pandemic period was reduced compared to that of participants before the COVID-19 period. Respondents during the COVID-19 pandemic have fewer negative feelings towards computers, based on their answers in contrast to the participants in the study before the COVID-19 pandemic. Computer anxiety and attitudes have change among nursing students among COVID-19 pandemic. Nursing students after the implementation of online training are reporting positive feeling towards computer use and are more confident for their ICT skills.", "doi": "10.1007/978-3-031-31986-0_37", "pmid": "37581812", "labels": {"Type: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:26:12.089Z", "modified": "2023-10-06T04:49:37.366Z"}, {"entity": "publication", "iuid": "eb4c2d66486d424195bec82ba310b6ab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb4c2d66486d424195bec82ba310b6ab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb4c2d66486d424195bec82ba310b6ab"}}, "title": "Inequalities in COVID-19 severe morbidity and mortality by country of birth in Sweden.", "authors": [{"family": "Rostila", "given": "Mikael", "initials": "M", "orcid": "0000-0002-6973-0381", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42aa27e8e952465daa11c765ad564808.json"}}, {"family": "Cederstr\u00f6m", "given": "Agneta", "initials": "A"}, {"family": "Wallace", "given": "Matthew", "initials": "M", "orcid": "0000-0002-8318-7952", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e784144db22491f98c4a7ced1fdfab7.json"}}, {"family": "Aradhya", "given": "Siddartha", "initials": "S", "orcid": "0000-0003-3748-6270", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07f9e1a0528249a7ba6d39e2c0f3a7fe.json"}}, {"family": "Ahrne", "given": "Malin", "initials": "M"}, {"family": "Ju\u00e1rez", "given": "Sol P", "initials": "SP"}], "type": "journal article", "published": "2023-08-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "14", "issue": "1", "pages": "4919"}, "abstract": "Migrants have been more affected by the COVID-19 pandemic. Whether this has varied over the course of the pandemic remains unknown. We examined how inequalities in intensive care unit (ICU) admission and death related to COVID-19 by country of birth have evolved over the course of the pandemic, while considering the contribution of social conditions and vaccination uptake. A population-based cohort study was conducted including adults living in Sweden between March 1, 2020 and June 1, 2022 (n = 7,870,441). Poisson regressions found that migrants from Africa, Middle East, Asia and European countries without EU28/EEA, UK and Switzerland had higher risk of COVID-19 mortality and ICU admission than Swedish-born. High risks of COVID-19 ICU admission was also found in migrants from South America. Inequalities were generally reduced through subsequent waves of the pandemic. In many migrant groups socioeconomic status and living conditions contributed to the disparities while vaccination campaigns were decisive when such became available.", "doi": "10.1038/s41467-023-40568-4", "pmid": "37582909", "labels": {"Type: Journal article": null, "Funder: Forte": null, "Category: Public Health": null, "Category: Social Science & Humanities": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC10427621"}, {"db": "pii", "key": "10.1038/s41467-023-40568-4"}], "notes": [], "created": "2023-10-05T08:02:36.268Z", "modified": "2023-10-05T08:47:35.755Z"}, {"entity": "publication", "iuid": "380828967d5742d18e08ee66be00f624", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/380828967d5742d18e08ee66be00f624.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/380828967d5742d18e08ee66be00f624"}}, "title": "Influence of experience, tenure, and organisational preparedness on nurses' readiness in responding to disasters: An exploration during the COVID-19 pandemic.", "authors": [{"family": "Goniewicz", "given": "Mariusz", "initials": "M"}, {"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}, {"family": "W\u0142oszczak-Szubzda", "given": "Anna", "initials": "A"}, {"family": "Lasota", "given": "Dorota", "initials": "D"}, {"family": "Al-Wathinani", "given": "Ahmed M", "initials": "AM"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}], "type": "journal article", "published": "2023-08-14", "journal": {"title": "J Glob Health", "issn": "2047-2986", "issn-l": "2047-2978", "volume": "13", "issue": null, "pages": "06034"}, "abstract": "The coronavirus 2019 (COVID-19) pandemic has placed unprecedented challenges on the nursing practice, particularly in Poland. Nurses, as crucial healthcare service providers, have faced organisational disruptions, altered working conditions, and heightened professional anxieties.\r\n\r\nWe undertook a comprehensive survey across all medical centres in Lublin, Poland in 2020 to understand nurses' attitudes towards their roles and working conditions during the pandemic. This involved 470 nurses completing a questionnaire which focused on four pivotal areas: readiness to be on call in a disaster situation (even when not formally asked); willingness to work overtime in a disaster without additional compensation, preparedness to undertake health risks by caring for individuals with infectious diseases or exposure to hazardous substances, and willingness to be transferred to other departments during a disaster.\r\n\r\nWe found that excessive workload, fear of infection, and feelings of helplessness significantly influenced nurses' readiness to work overtime, particularly when unpaid. We also presented the ethical dilemmas that nurses encountered during the pandemic and how these dilemmas affected their decision-making processes. We further explored the impact of variables such as nurses' professional experience, tenure, and level of organisational preparedness on their readiness to respond to crisis situations.\r\n\r\nGaining an understanding of nurses' perspectives is key for formulating strategies to bolster their professional engagements and resilience during crises. Addressing these issues can help build a more robust and well-prepared healthcare system that can effectively navigate future crises.", "doi": "10.7189/jogh.13.06034", "pmid": "37572372", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10423066"}], "notes": [], "created": "2023-10-05T08:26:54.564Z", "modified": "2023-10-06T05:17:33.511Z"}, {"entity": "publication", "iuid": "5f742fa06f844a49b6242edfc3f1de15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f742fa06f844a49b6242edfc3f1de15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f742fa06f844a49b6242edfc3f1de15"}}, "title": "Waning protection after vaccination and prior infection against COVID-19-related mortality over 18 months.", "authors": [{"family": "Dietler", "given": "Dominik", "initials": "D"}, {"family": "Kahn", "given": "Fredrik", "initials": "F"}, {"family": "Inghammar", "given": "Malin", "initials": "M"}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2023-08-12", "journal": {"title": "Clin Microbiol Infect", "issn": "1469-0691", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Evidence on waning patterns in protection from vaccine-induced, infection-induced, and hybrid immunity against death is scarce. The aim of this study is to assess the temporal trends in protection against mortality.\r\n\r\nPopulation-based case-control study nested in the total population of Scania Region, Sweden using individual-level registry data of COVID-19-related deaths (<30 days after positive SARS-CoV-2 test) between 27 December 2020 and 3 June 2022. Controls were matched for age, sex, and index date. Conditional logistic regression was used to estimate the preventable fraction (PF) from vaccination (PFvac corresponding to vaccine effectiveness; \u22652 vaccine doses vs. 0 doses), prior infection (PFinf), and hybrid immunity (PFhybrid). PF was calculated as one minus odds ratio. Models were adjusted for comorbidities, long-term care facility residence, prior infection (for PFvac), country of birth, socio-economic conditions, and time since last vaccination (for PFinf).\r\n\r\nIn total, 14 936 individuals (1440 COVID-19-related deaths and 13 496 controls) were included in the case-control analyses (45% females, median age: 84 years). PFvac was above 90% during the first month after vaccination, regardless of the number of vaccine doses. After 6 months, PFvac of two doses waned to 34% (95% CI: -30% to 66%). PFinf for people surviving a SARS-CoV-2 infection waned from 88% (-16% to 99%) 3 months after infection to 62% (34-79%) after 9 months. No differences in waning patterns in PFvac were seen between virus variants, gender, and age.\r\n\r\nGiven the waning of protection against death, continuous surveillance of population immunity status, particularly among the most vulnerable population groups, could help to further fine-tune vaccination recommendations.", "doi": "10.1016/j.cmi.2023.08.007", "pmid": "37580016", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Public Health": null, "Funder: Vinnova": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(23)00388-9"}], "notes": [], "created": "2023-10-05T08:02:23.898Z", "modified": "2023-10-05T08:41:21.267Z"}, {"entity": "publication", "iuid": "8525adc10add43ec92a8865a509bd63b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8525adc10add43ec92a8865a509bd63b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8525adc10add43ec92a8865a509bd63b"}}, "title": "Central nervous system biomarkers GFAp and NfL associate with post-acute cognitive impairment and fatigue following critical COVID-19.", "authors": [{"family": "Bark", "given": "Lovisa", "initials": "L"}, {"family": "Larsson", "given": "Ing-Marie", "initials": "I"}, {"family": "Wallin", "given": "Ewa", "initials": "E"}, {"family": "Simr\u00e9n", "given": "Joel", "initials": "J"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2023-08-12", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "13144"}, "abstract": "A high proportion of patients with coronavirus disease 2019 (COVID-19) experience post-acute COVID-19, including neuropsychiatric symptoms. Objective signs of central nervous system (CNS) damage can be investigated using CNS biomarkers such as glial fibrillary acidic protein (GFAp), neurofilament light chain (NfL) and total tau (t-tau). We have examined whether CNS biomarkers can predict fatigue and cognitive impairment 3-6 months after discharge from the intensive care unit (ICU) in critically ill COVID-19 patients. Fifty-seven COVID-19 patients admitted to the ICU were included with analysis of CNS biomarkers in blood at the ICU and at follow up. Cognitive dysfunction and fatigue were assessed with the Montreal Cognitive Assessment (MoCA) and the Multidimensional Fatigue inventory (MFI-20). Elevated GFAp at follow-up 3-6 months after ICU discharge was associated to the development of mild cognitive dysfunction (p = 0.01), especially in women (p = 0.005). Patients who experienced different dimensions of fatigue at follow-up had significantly lower GFAp in both the ICU and at follow-up, specifically in general fatigue (p = 0.009), physical fatigue (p = 0.004), mental fatigue (p = 0.001), and reduced motivation (p = 0.001). Women showed a more pronounced decrease in GFAp compared to men, except for in mental fatigue where men showed a more pronounced GFAp decrease compared to women. NfL concentration at follow-up was lower in patients who experienced reduced motivation (p = 0.004). Our findings suggest that GFAp and NfL are associated with neuropsychiatric outcome after critical COVID-19.Trial registration The study was registered \u00e0 priori (clinicaltrials.gov: NCT04316884 registered on 2020-03-13 and NCT04474249 registered on 2020-06-29).", "doi": "10.1038/s41598-023-39698-y", "pmid": "37573366", "labels": {"Funder: VR": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: KAW/SciLifeLab": null, "Category: Post-COVID": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10423244"}, {"db": "pii", "key": "10.1038/s41598-023-39698-y"}, {"db": "ClinicalTrials.gov", "key": "NCT04316884"}, {"db": "ClinicalTrials.gov", "key": "NCT04474249"}], "notes": [], "created": "2023-10-05T08:02:46.150Z", "modified": "2023-10-05T08:52:57.648Z"}, {"entity": "publication", "iuid": "19645b528efb4222a1fa99f67fcfa83f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19645b528efb4222a1fa99f67fcfa83f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19645b528efb4222a1fa99f67fcfa83f"}}, "title": "Transparency in Infectious Disease Research: Meta-research Survey of Specialty Journals.", "authors": [{"family": "Zavalis", "given": "Emmanuel A", "initials": "EA"}, {"family": "Contopoulos-Ioannidis", "given": "Despina G", "initials": "DG"}, {"family": "Ioannidis", "given": "John P A", "initials": "JPA"}], "type": "journal article", "published": "2023-08-11", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899", "volume": "228", "issue": "3", "pages": "227-234"}, "abstract": "Infectious diseases carry large global burdens and have implications for society at large. Therefore, reproducible, transparent research is extremely important.\r\n\r\nWe evaluated transparency indicators (code and data sharing, registration, and conflict and funding disclosures) in the 5340 PubMed Central Open Access articles published in 2019 or 2021 in the 9 most cited specialty journals in infectious diseases using the text-mining R package, rtransparent.\r\n\r\nA total of 5340 articles were evaluated (1860 published in 2019 and 3480 in 2021 [of which 1828 were on coronavirus disease 2019, or COVID-19]). Text mining identified code sharing in 98 (2%) articles, data sharing in 498 (9%), registration in 446 (8%), conflict of interest disclosures in 4209 (79%), and funding disclosures in 4866 (91%). There were substantial differences across the 9 journals: 1%-9% for code sharing, 5%-25% for data sharing, 1%-31% for registration, 7%-100% for conflicts of interest, and 65%-100% for funding disclosures. Validation-corrected imputed estimates were 3%, 11%, 8%, 79%, and 92%, respectively. There were no major differences between articles published in 2019 and non-COVID-19 articles in 2021. In 2021, non-COVID-19 articles had more data sharing (12%) than COVID-19 articles (4%).\r\n\r\nData sharing, code sharing, and registration are very uncommon in infectious disease specialty journals. Increased transparency is required.", "doi": "10.1093/infdis/jiad130", "pmid": "37132475", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7150367"}], "notes": [], "created": "2023-10-04T05:09:56.676Z", "modified": "2023-10-04T06:24:40.130Z"}, {"entity": "publication", "iuid": "7a9030d1303f42c58b565c64d9aa8399", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a9030d1303f42c58b565c64d9aa8399.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a9030d1303f42c58b565c64d9aa8399"}}, "title": "Real-World Utilization of Molnupiravir during the COVID-19 Omicron Surge in Israel.", "authors": [{"family": "Weil", "given": "Clara", "initials": "C", "orcid": "0000-0002-0174-7208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7720ae3cd164504b6b6cb631a334704.json"}}, {"family": "Bergroth", "given": "Tobias", "initials": "T"}, {"family": "Eisenberg", "given": "Anna", "initials": "A", "orcid": "0000-0003-4292-0967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/983fc62ecb3544619b5430598e7a50c9.json"}}, {"family": "Whiteside", "given": "Yohance Omar", "initials": "YO", "orcid": "0000-0002-7828-3018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce7b53acac3441df9dc098073b66b995.json"}}, {"family": "Caraco", "given": "Yoseph", "initials": "Y"}, {"family": "Tene", "given": "Lilac", "initials": "L"}, {"family": "Chodick", "given": "Gabriel", "initials": "G", "orcid": "0000-0002-5189-8995", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed9fe6a3219549849c751198e9c47e1c.json"}}], "type": "journal article", "published": "2023-08-10", "journal": {"title": "Epidemiologia (Basel)", "issn": "2673-3986", "issn-l": null, "volume": "4", "issue": "3", "pages": "309-321"}, "abstract": "Molnupiravir (MOV) was introduced in Israel in January 2022 during the SARS-CoV-2 Omicron surge for high-risk patients contraindicated for nirmatrelvir/ritonavir. This retrospective cohort study aimed to describe characteristics of patients offered COVID-19 antiviral treatment in Maccabi Healthcare Services (antiviral treatment-eligible cohort; n = 5596) between 12 January and 28 February 2022, and the subset of these who were dispensed MOV (MOV-treated cohort; n = 1147), as well as outcomes following MOV dispensation. Median (interquartile range) age in the antiviral treatment-eligible and MOV-treated cohorts were 70.5 (61.1, 77.3) and 74.1 (64.3, 81.7) years, respectively. The MOV-treated cohort (male: 53.2%) had high rates of COVID-19 vaccination (91.4%) and comorbidities, including immunosuppression (40.0%) and chronic kidney disease (67.0%; eGFR < 30 mL/min/1.73 m2: 28.8%), and most used comedications either contraindicated or with major potential for drug-drug interactions with nirmatrelvir/ritonavir (87.3%). At 28 days post-MOV dispensation, the cumulative incidence (95% CI) of COVID-19-related hospitalization and/or all-cause mortality was 3.6% (2.5%, 4.6%), with similar rates across sexes and age groups (18-64 vs. \u226565 years), and lower rates among recently vaccinated and/or recently SARS-CoV-2-infected patients. These data describe the characteristics and outcomes for MOV-treated patients in Israel, whose clinical characteristics may preclude the use of nirmatrelvir/ritonavir to treat their COVID-19 infection.", "doi": "10.3390/epidemiologia4030031", "pmid": "37606468", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10443270"}, {"db": "pii", "key": "epidemiologia4030031"}], "notes": [], "created": "2023-10-05T08:01:45.632Z", "modified": "2023-10-05T08:34:09.246Z"}, {"entity": "publication", "iuid": "170e5853d8cc408d975bf1beb2797485", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/170e5853d8cc408d975bf1beb2797485.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/170e5853d8cc408d975bf1beb2797485"}}, "title": "Asthma in the era of COVID-19.", "authors": [{"family": "Assaf", "given": "Sara", "initials": "S"}, {"family": "Stenberg", "given": "Henning", "initials": "H"}, {"family": "Jesenak", "given": "Milos", "initials": "M"}, {"family": "Tarasevych", "given": "Svitlana P", "initials": "SP"}, {"family": "Hanania", "given": "Nicola A", "initials": "NA"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}], "type": "journal article", "published": "2023-08-10", "journal": {"title": "Respir Med", "issn": "1532-3064", "issn-l": "0954-6111", "volume": "218", "issue": null, "pages": "107373"}, "abstract": "Since its global invasion in 2019, COVID-19 has affected several aspects of patients' lives and posed a significant impact on the health care system. Several patient populations were identified to be at high risk of contracting SARS-CoV-2 infection and/or developing severe COVID-19-related sequelae. Conversely, anyone who has contracted SARS-CoV-2 is at risk to experience symptoms and signs consistent with post-COVID manifestations. Patients with asthma were initially thought to be at increased risk and severity for SARS-CoV-2 infection. However, accumulating evidence demonstrates that asthma endotypes/phenotypes and comorbidities influence the risk stratification in this population. Furthermore, initial concerns about the potentially increased risk of poor outcomes with asthma treatments such as inhaled corticosteroids and biologics have not been substantiated. In this review, we provide an update on COVID-19 and asthma, including risk of susceptibility, clinical manifestations and course in this population as well as discuss recommendations for management.", "doi": "10.1016/j.rmed.2023.107373", "pmid": "37567514", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0954-6111(23)00261-5"}], "notes": [], "created": "2023-10-05T08:01:36.893Z", "modified": "2023-10-05T08:29:04.018Z"}, {"entity": "publication", "iuid": "a387f635b5584204bd765f1418785203", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a387f635b5584204bd765f1418785203.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a387f635b5584204bd765f1418785203"}}, "title": "Effects of the COVID-19 pandemic on the physical activity and screen time habits of children aged 11-13 years in Sweden.", "authors": [{"family": "Berggren", "given": "Sara", "initials": "S"}, {"family": "Almquist-Tangen", "given": "Gerd", "initials": "G"}, {"family": "Wolfbrandt", "given": "Olivia", "initials": "O"}, {"family": "Roswall", "given": "Josefine", "initials": "J"}], "type": "journal article", "published": "2023-08-09", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "1241938"}, "abstract": "Physical activity (PA), exercise, sedentary behavior and screen time are lifestyle factors that have been shown to significantly impact child health in different ways. These lifestyle factors were affected to different degrees by global restrictions during the COVID-19 pandemic. We investigated PA and screen time in a cohort of Swedish children in both 2019 and 2021, before and during the pandemic.\r\n\r\nAdolescents born in 2008 in Halland, Sweden, and included in a previous longitudinal birth cohort study were invited to take part in follow-up questionnaires about PA, screen time and COVID-19. A total of 1041 children aged 11 (in 2019) and 13 years (in 2021) replied and 777 of them answered on both occasions.\r\n\r\nMost children (42.1%) reported that their leisure time PA was unchanged from 2019 to 2021. Compared to unchanged PA 33.9% exercised more often (p = 0.011) and 23.9% exercised less (p < 0.001), both differences statistically significant. Roughly, 43.2% of boys and 34.9% of girls in 2021 exercised so that they became breathless or broke a sweat at least 4 times a week not counting physical education in school, corresponding figures for 2019 were 38.2% for boys and 35.2% for girls. The majority of children were able to continue attending leisure time sports clubs during the pandemic, but participation decreased from 88.3% to 76.3% from 11 to 13 years of age. Most reported that sports club routines changed during the pandemic, but only 40.9% reported fewer practice opportunities. Attending a sports club gave greater protection against loss of PA during the pandemic than not belonging to one (41.0% vs. 23.2%, p < 0.001). The majority (71.1%) of children spent more time on screens in 2021 than 2019, with a mean increase of 9.4 h (95% CI 8.6 to 10.2 h) from 20.7 to 30.1 hours per week (p < 0.001) during the study.\r\n\r\nSwedish children largely maintained their levels of PA during the pandemic at 13 years of age and these were possibly safeguarded by the comparably mild pandemic restrictions in Sweden in 2021. However, they did increase their screen time between 11 and 13 years of age.", "doi": "10.3389/fpubh.2023.1241938", "pmid": "37637825", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10447604"}], "notes": [], "created": "2023-10-05T08:26:38.406Z", "modified": "2023-10-06T05:01:54.058Z"}, {"entity": "publication", "iuid": "170bf933f9e242adac8adf3c85197e5f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/170bf933f9e242adac8adf3c85197e5f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/170bf933f9e242adac8adf3c85197e5f"}}, "title": "Regular Inhaled Corticosteroids Use May Protect Against Severe COVID-19 Outcome in COPD.", "authors": [{"family": "Labor", "given": "Marina", "initials": "M", "orcid": "0000-0001-5216-8129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9a750b29a224b7bb07d535004dfdf15.json"}}, {"family": "Kirui", "given": "Brian K", "initials": "BK", "orcid": "0000-0002-6656-6029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b22b96547b344c79b3780723af1f30e0.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW", "orcid": "0000-0002-4387-4096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bb5d1f761ef48c4837ed4f984717f0e.json"}}], "type": "journal article", "published": "2023-08-07", "journal": {"title": "Int J Chron Obstruct Pulmon Dis", "issn": "1178-2005", "issn-l": null, "volume": "18", "issue": null, "pages": "1701-1712"}, "abstract": "Population-based studies provide conflicting evidence about how inhaled corticosteroids (ICS) impact COVID-19 outcomes among COPD patients. We investigated whether regular ICS exposure affects risk, severity, or survival in SARS-CoV-2 infection, using a nationwide linked Swedish population register database.\r\n\r\nDuring January-December 2020, we studied two defined Swedish adult populations - Whole population [\u226540 years] (N = 5243479), and COPD subpopulation [\u226540 years] (N = 133372), in three study cohorts, respectively: 1. Overall cohort (index date 1 Jan 2020), 2. COVID-19 diagnosed sub-cohort (index date = diagnosis date), and 3. COVID-19 hospitalized sub-cohort (index date = admission date). Regular exposure was defined as \u22653 ICS prescriptions in the year before index. Hazard ratios (HRs) for outcomes (COVID-19 onset, hospitalization, ICU admission, or death) related to ICS exposure were estimated using Cox regression. Confounding was controlled by propensity score methods applying Average Treatment effect in the Treated (ATT) weighting.\r\n\r\nRegular ICS use was associated with only very slightly increased onset of COVID-19, hospitalization, ICU admission, and death in the overall whole population cohort and in the overall COPD subpopulation cohort, except for ICU admission (marginally non-significant HRs, up to 1.13); and no clear increase in the diagnosed sub-cohorts. However, in the COVID-19 hospitalized COPD sub-cohort, ICS therapy showed reduced risks against progression to ICU admission and death, significant for death (HR 0.82 95% CI [0.67-0.99]).\r\n\r\nFor COPD patients, ICS therapy offers some protection against progression to ICU admission and death among COVID-19 hospitalized patients. Our findings alleviate concerns about increased risks of COVID-19 by ICS treatment and provide evidence supporting the continuation of ICS therapy for COPD patients.", "doi": "10.2147/COPD.S404913", "pmid": "37576828", "labels": {"Funder: VR": null, "Category: Public Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC10421743"}, {"db": "pii", "key": "404913"}], "notes": [], "created": "2023-10-05T08:01:51.832Z", "modified": "2023-10-05T08:36:13.679Z"}, {"entity": "publication", "iuid": "90cc886cb05544c79682111b99061687", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90cc886cb05544c79682111b99061687.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90cc886cb05544c79682111b99061687"}}, "title": "Attachment and trauma-informed programme to support forcibly displaced parents of youth in Sweden: feasibility and preliminary outcomes of the eConnect Online programme.", "authors": [{"family": "Kristen", "given": "Anna", "initials": "A", "orcid": "0000-0002-6020-7711", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5c8e51cf2423417a8e0a2c7dc91b423f.json"}}, {"family": "Salari", "given": "Raziye", "initials": "R", "orcid": "0000-0002-6363-4030", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e135f6c46ce47af8be2b490675d4f3f.json"}}, {"family": "Moretti", "given": "Marlene", "initials": "M"}, {"family": "Osman", "given": "Fatumo", "initials": "F", "orcid": "0000-0002-0038-9402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4384d1f8230f4c939d1e5e0025e53013.json"}}], "type": "journal article", "published": "2023-08-07", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "8", "pages": "e072368"}, "abstract": "To assess the feasibility, acceptability and the impact of an online parenting programme for forcibly displaced parents of adolescents.\r\n\r\nThe study was a single-arm feasibility study using pre-intervention post-intervention and follow-up assessments.\r\n\r\nParticipants were recruited from municipality-based activities for refugee parents in a small city in the south of Sweden.\r\n\r\nParticipants were forcibly displaced parents (n=23; 47.8% maternal figures) of youth (n=23; 8-17 years old; 26.1% female) from Syria, Afghanistan and Somalia participating in an online parenting programme (eConnect).\r\n\r\neConnect is an attachment-based and trauma-informed parenting intervention and was delivered over the course of 10 weekly sessions.\r\n\r\nFeasibility was assessed by programme enrolment, attendance, completion and acceptability of the online platform and cultural fit of the programme. Primary outcome measures were programme impact on youth mental health problems. Secondary outcome measures were programme impact on family functioning and parent-child attachment insecurity.\r\n\r\nThe eConnect programme was highly feasible in terms of overall enrolment (100%), attendance (89.6%) and retention rates (100%). The online platform was acceptable, with mixed feedback primarily related to the access and usage of technology. Cultural fit of the programme was acceptable. Youth mental health problems (\u03b7 2=0.29) and family functioning significantly improved (\u03b7 2=0.18) over the course of the programme. Unexpectedly, parent reports of youth attachment insecurity significantly worsened (\u03b7 2=0.16).\r\n\r\nThe findings suggest that the online delivery of Connect was a promising way to reduce barriers to service access and improve mental health problems and family functioning among forcibly displaced parents and their children during COVID-19. Future research is needed to explore the acceptability and impact of this programme post-COVID-19, and to develop culturally tailored and psychometrically sound measures for parent and youth reports of attachment.", "doi": "10.1136/bmjopen-2023-072368", "pmid": "37550024", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10407377"}, {"db": "pii", "key": "bmjopen-2023-072368"}], "notes": [], "created": "2023-10-05T08:26:46.032Z", "modified": "2023-10-06T05:05:48.123Z"}, {"entity": "publication", "iuid": "654c48374d554572b94bcccd5d03900e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/654c48374d554572b94bcccd5d03900e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/654c48374d554572b94bcccd5d03900e"}}, "title": "National trends in depression and suicide attempts and COVID-19 pandemic-related factors, 1998-2021: A nationwide study in South Korea.", "authors": [{"family": "Kang", "given": "Jiseung", "initials": "J"}, {"family": "Park", "given": "Jaeyu", "initials": "J"}, {"family": "Lee", "given": "Hojae", "initials": "H"}, {"family": "Lee", "given": "Myeongcheol", "initials": "M"}, {"family": "Kim", "given": "Sunyoung", "initials": "S"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Smith", "given": "Lee", "initials": "L"}, {"family": "Kim", "given": "Min Seo", "initials": "MS"}, {"family": "Rahmati", "given": "Masoud", "initials": "M"}, {"family": "Fond", "given": "Guillaume", "initials": "G"}, {"family": "Boyer", "given": "Laurent", "initials": "L"}, {"family": "L\u00f3pez S\u00e1nchez", "given": "Guillermo F", "initials": "GF"}, {"family": "Elena", "given": "Dragioti", "initials": "D"}, {"family": "Cortese", "given": "Samuele", "initials": "S"}, {"family": "Kim", "given": "Tae", "initials": "T"}, {"family": "Yon", "given": "Dong Keon", "initials": "DK"}], "type": "journal article", "published": "2023-08-06", "journal": {"title": "Asian J Psychiatr", "issn": "1876-2026", "issn-l": null, "volume": "88", "issue": null, "pages": "103727"}, "abstract": "Despite the significant psychiatric effects of the COVID-19 pandemic, there's limited data on the prevalence and risk factors of depression and suicide attempts among South Korean adults.\r\n\r\nA nationwide cross-sectional study using the Korea National Health and Nutrition Examination Survey (KNHANES) data from 1998 to 2021 was conducted. Changes in prevalence and risk factors for depression and suicide attempts were assessed using weighted odds ratios or weighted beta coefficients.\r\n\r\nDuring the observation period (1998-2021), the prevalence of depression increased in the overall population; however, no significant surge was found regarding the COVID-19 pandemic, from 2.78% (95% CI, 2.41-3.15) in 1998-2005-4.96% (4.32-5.61) in 2020 and 5.06% (4.43-5.69) in 2021. However, immediately after the onset of the pandemic, younger ages, male sex, urban residence, higher education, and high economic status became significant vulnerable factors compared to pre-pandemic periods. The prevalence of suicide attempts remained stable, and there was no notable surge specifically related to the COVID-19 pandemic, from 0.23% (95% CI, 0.18-0.28) in 1998-2005-0.45% (0.25-0.66) in 2020 and 0.42% (0.24-0.60) in 2021. Furthermore, no distinct vulnerable factors associated with suicide attempts have been identified.\r\n\r\nThrough this nationwide serial cross-sectional survey study, we emphasized the need for understanding the differential impacts of global crises, such as COVID-19, across varied population subgroups, thereby highlighting the importance of specific and targeted mental health support strategies.", "doi": "10.1016/j.ajp.2023.103727", "pmid": "37633158", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S1876-2018(23)00283-6"}], "notes": [], "created": "2023-10-05T08:26:14.345Z", "modified": "2023-10-06T04:52:01.848Z"}, {"entity": "publication", "iuid": "f910f94cd1d24cac87d244b467352d0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f910f94cd1d24cac87d244b467352d0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f910f94cd1d24cac87d244b467352d0e"}}, "title": "COVID-19 among migrants, refugees, and internally displaced persons: systematic review, meta-analysis and qualitative synthesis of the global empirical literature", "authors": [{"family": "Hintermeier", "given": "Maren", "initials": "M"}, {"family": "Gottlieb", "given": "Nora", "initials": "N"}, {"family": "Rohleder", "given": "Sven", "initials": "S"}, {"family": "Oppenberg", "given": "Jan", "initials": "J"}, {"family": "Baroudi", "given": "Mazen", "initials": "M"}, {"family": "Pernitez-Agan", "given": "Sweetmavourneen", "initials": "S"}, {"family": "Lopez", "given": "Janice", "initials": "J"}, {"family": "Flores", "given": "Sergio", "initials": "S"}, {"family": "Mohsenpour", "given": "Amir", "initials": "A", "orcid": "0000-0001-8419-2430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45c5089d3d844b86b2556c2405d3bdba.json"}}, {"family": "Wickramage", "given": "Kolitha", "initials": "K"}, {"family": "Bozorgmehr", "given": "Kayvan", "initials": "K", "orcid": "0000-0002-1411-1209", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d618d677fbb34dccb3439d863b131350.json"}}], "type": "posted-content", "published": "2023-08-06", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.08.03.23293586", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:02:28.486Z", "modified": "2023-10-05T08:44:03.578Z"}, {"entity": "publication", "iuid": "3097f975fd2649e4b28e4007f8b731b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3097f975fd2649e4b28e4007f8b731b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3097f975fd2649e4b28e4007f8b731b1"}}, "title": "Alcohol, drug and tobacco prevention in Swedish municipalities - impact from the COVID-19 pandemic considering socio-demographic context.", "authors": [{"family": "Owen", "given": "Ulrika", "initials": "U"}, {"family": "M\u00e5nsdotter", "given": "Anna", "initials": "A"}, {"family": "Guldbrandsson", "given": "Karin", "initials": "K"}, {"family": "Lindstr\u00f6m", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2023-08-04", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": null, "issue": null, "pages": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic and measures to prevent the spread of the virus challenged public health practice at the local level in Sweden. The objective of this study was to explore the impact of the pandemic on the prevention of alcohol, drugs and tobacco (ADT) in Sweden during 2020-21 considering socio-demographic context.\r\n\r\nData were collected through the Public Health Agency's survey on ADT prevention in Swedish municipalities (N = 290). This study used data from 2020 and 2021, with a response rate of 90% and 88%, respectively. Survey data were analyzed in logistic regression models (odds ratios, P < 0.05, 95% confidence intervals) against variables of education level, income level and population size from national registers.\r\n\r\nA majority (n = 198, 76%) of the municipalities reported a decrease in ADT prevention during the pandemic. No correlation between the decrease in ADT prevention and socio-demographic conditions was detected. A majority (2020: n = 165, 63%; 2021: n = 174, 68%) of the municipalities also reported that ADT prevention was adapted, however less common in smaller municipalities and municipalities where residents had lower levels of education and lower incomes.\r\n\r\nADT prevention carried out by municipalities in Sweden was initially (2020) deeply affected by the preventive strategies against COVID-19. Adaptation of activities was less common in municipalities with more vulnerable socio-demographic situation. In policy, practice and research, the findings are important not only for continued progress on the national goal of equity in health but also for preparedness for future crises.", "doi": "10.1093/eurpub/ckad127", "pmid": "37541832", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "7237445"}], "notes": [], "created": "2023-10-05T08:26:09.552Z", "modified": "2023-10-06T04:48:21.765Z"}, {"entity": "publication", "iuid": "b025ee64be20412b8be8a8a218882fa0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b025ee64be20412b8be8a8a218882fa0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b025ee64be20412b8be8a8a218882fa0"}}, "title": "Acceptability of restrictions in the COVID-19 pandemic: a population-based survey in Denmark and Sweden.", "authors": [{"family": "Nilsen", "given": "Per", "initials": "P"}, {"family": "Seing", "given": "Ida", "initials": "I"}, {"family": "Sekhon", "given": "Mandeep", "initials": "M"}, {"family": "Kallemose", "given": "Thomas", "initials": "T"}, {"family": "Tj\u00f8rnh\u00f8j-Thomsen", "given": "Tine", "initials": "T"}, {"family": "Stef\u00e1nsd\u00f3ttir", "given": "Nina Th\u00f3rn\u00fd", "initials": "NT"}, {"family": "Vrangb\u00e6k", "given": "Karsten", "initials": "K"}, {"family": "Andersen", "given": "Ove", "initials": "O"}, {"family": "Kirk", "given": "Jeanette Wassar", "initials": "JW"}], "type": "journal article", "published": "2023-08-03", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "988882"}, "abstract": "Denmark and Sweden initially adopted different responses to the COVID-19 pandemic although the two countries share many characteristics. Denmark responded swiftly with many mandatory restrictions. In contrast, Sweden relied on voluntary restrictions and a more \"relaxed\" response during the first wave of the pandemic. However, increased rates of COVID-19 cases led to a new approach that involved many more mandatory restrictions, thus making Sweden's response similar to Denmark's in the second wave of the pandemic.\r\n\r\nThe aim was to investigate and compare the extent to which the populations in Denmark and Sweden considered the COVID-19 restrictions to be acceptable during the first two waves of the pandemic. The study also aimed to identify the characteristics of those who were least accepting of the restrictions in the two countries.\r\n\r\nCross-sectional surveys were conducted in Denmark and Sweden in 2021. The study population was sampled from nationally representative web panels in the two countries, consisting of 2,619 individuals from Denmark and 2,633 from Sweden. The questionnaire captured key socio-demographic characteristics. Acceptability was operationalized based on a theoretical framework consisting of seven constructs and one overarching construct.\r\n\r\nThe respondents' age and gender patterns were similar in the two countries. The proportion of respondents in Denmark who agreed with the statements (\"agree\" alternative) that captured various acceptability constructs was generally higher for the first wave than the second wave of the pandemic. The opposite pattern was seen for Sweden. In Denmark, 66% in the first wave and 50% in the second wave were accepting of the restrictions. The corresponding figures for Sweden was 42% (first wave) and 47% (second wave). Low acceptance of the restrictions, defined as the 25% with the lowest total score on the seven acceptability statements, was associated with younger age, male gender and lower education levels.\r\n\r\nRespondents in Sweden were more accepting of the restrictions in the second wave, when the country used many mandatory restrictions. In contrast, respondents in Denmark were more accepting of the restrictions in the first wave than in the second wave, implying an increased weariness to comply with the restrictions over time. There were considerable socio-demographic differences between those who expressed low acceptance of the restrictions and the others in both countries, suggesting the importance of tailoring communication about the pandemic to different segments of the population.", "doi": "10.3389/fpubh.2023.988882", "pmid": "37601192", "labels": {"Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10434523"}], "notes": [], "created": "2023-10-05T08:26:33.525Z", "modified": "2023-10-06T04:59:24.120Z"}, {"entity": "publication", "iuid": "d50f06e75b39478fa4be8f1aef867936", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d50f06e75b39478fa4be8f1aef867936.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d50f06e75b39478fa4be8f1aef867936"}}, "title": "Waves of inequality: income differences in intensive care due to Covid-19 in Sweden.", "authors": [{"family": "Gauffin", "given": "Karl", "initials": "K", "orcid": "0000-0001-9349-9936", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40b610dc330245929d1c3ea558ef9af4.json"}}, {"family": "\u00d6stergren", "given": "Olof", "initials": "O", "orcid": "0000-0002-7156-3260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d22b6331dfb4bd88e2935d0ddec1dd3.json"}}, {"family": "Cederstr\u00f6m", "given": "Agneta", "initials": "A"}], "type": "journal article", "published": "2023-08-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": "33", "issue": "4", "pages": "574-579"}, "abstract": "Socioeconomically vulnerable groups were overall more likely to develop severe Covid-19, but specific conditions in terms of preparedness, knowledge and the properties of the virus itself changed during the course of the pandemic. Inequalities in Covid-19 may therefore shift over time. This study examines the relationship between income and intensive care (ICU) episodes due to Covid-19 in Sweden during three distinct waves.\r\n\r\nThis study uses Swedish register data on the total adult population and estimates the relative risk (RR) of ICU episodes due to Covid-19 by income quartile for each month between March 2020 and May 2022, and for each wave, using Poisson regression analyses.\r\n\r\nThe first wave had modest income-related inequalities, while the second wave had a clear income gradient, with the lowest income quartile having an increased risk compared to the high-income group [RR: 1.55 (1.36-1.77)]. In the third wave, the overall need for ICU decreased, but RRs increased, particularly in the lowest income quartile [RR: 3.72 (3.50-3.96)]. Inequalities in the third wave were partly explained by differential vaccination coverage by income quartile, although substantial inequalities remained after adjustment for vaccination status [RR: 2.39 (2.20-2.59)].\r\n\r\nThe study highlights the importance of considering the changing mechanisms that connect income and health during a novel pandemic. The finding that health inequalities increased as the aetiology of Covid-19 became better understood could be interpreted through the lens of adapted fundamental cause theory.", "doi": "10.1093/eurpub/ckad094", "pmid": "37322545", "labels": {"Category: Social Science & Humanities": null, "Funder: Forte": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10393505"}, {"db": "pii", "key": "7199199"}], "notes": [], "created": "2023-10-04T09:30:28.649Z", "modified": "2023-10-04T09:56:34.789Z"}, {"entity": "publication", "iuid": "4844edf1bca7409c8a29d94b9035ba7c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4844edf1bca7409c8a29d94b9035ba7c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4844edf1bca7409c8a29d94b9035ba7c"}}, "title": "Trajectory of COVID-19 vaccine hesitancy post-vaccination and public's intention to take booster vaccines: A cross-sectional analysis.", "authors": [{"family": "Salman", "given": "Muhammad", "initials": "M"}, {"family": "Mallhi", "given": "Tauqeer Hussain", "initials": "TH"}, {"family": "Khan", "given": "Yusra Habib", "initials": "YH"}, {"family": "Mustafa", "given": "Zia Ul", "initials": "ZU"}, {"family": "Khan", "given": "Muhammad Tanveer", "initials": "MT"}, {"family": "Khan", "given": "Faiz Ullah", "initials": "FU"}, {"family": "Butt", "given": "Muhammad Hammad", "initials": "MH", "orcid": "0000-0003-4387-1351", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6671444d83444ea2a1c68fcb309b6338.json"}}, {"family": "Shehzadi", "given": "Naureen", "initials": "N"}, {"family": "Farrukh", "given": "Muhammad Junaid", "initials": "MJ"}, {"family": "Waheed", "given": "Maria", "initials": "M"}, {"family": "Azmat", "given": "Fatima", "initials": "F"}, {"family": "Saeed", "given": "Areej", "initials": "A"}, {"family": "Mazhar", "given": "Syeda Ayesha", "initials": "SA"}, {"family": "Ali", "given": "Asim", "initials": "A"}, {"family": "Ashfaq", "given": "Aisha", "initials": "A"}, {"family": "Hussain", "given": "Khalid", "initials": "K"}], "type": "journal article", "published": "2023-08-01", "journal": {"title": "Hum Vaccin Immunother", "issn": "2164-554X", "issn-l": null, "volume": "19", "issue": "2", "pages": "2225990"}, "abstract": "Vaccine hesitancy (VH) is not a new phenomenon in Pakistan and is regarded as one of the primary causes of unsatisfactory vaccination campaigns. This study determined post-vaccination COVID-19 VH, factors influencing COVID-19 vaccine uptake, and public's intent to receive booster vaccinations. A cross-sectional study was conducted among adult population of Lahore, Pakistan. Participants were recruited via convenience sampling between March and May 2022. SPSS version 22 was used for the data analysis. A total of 650 participants were included in the study (age = 28.1 \u00b1 9.7 years; male-to-female ratio nearly 1: 1). The majority of participants received Sinopharm followed by Sinovac vaccine. The top three reasons of vaccine uptake were \"only vaccinated individuals are allowed at the workplace, and educational institutes\" (Relative importance index (RII) = 0.749), \"only vaccinated people are allowed to go to markets, malls and other public places\" (RII = 0.746), and \"protect myself from the infection\" (RII = 0.742). The mean COVID-19 VH score was 24.5 \u00b1 6.2 (95% CI 23.9-24.9), with not being pro-vaccines and poor economic status were the significant predictors of COVID-19 vaccine hesitancy among immunized individuals (p < .05). Acceptance of booster vaccines was negatively associated with younger age and a lower level of education. Furthermore, being pro-vaccine was associated with a greater likelihood of accepting booster vaccines (p = .001). The Pakistani public continues to express VH toward COVID-19 vaccines. Therefore, aggressive measures must be taken to combat the community factors that contribute to it.", "doi": "10.1080/21645515.2023.2225990", "pmid": "37350298", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10332231"}], "notes": [], "created": "2023-10-04T09:31:38.960Z", "modified": "2023-10-04T10:51:23.112Z"}, {"entity": "publication", "iuid": "c58419bfaf374d5ea21b7e947d6e9f8c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c58419bfaf374d5ea21b7e947d6e9f8c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c58419bfaf374d5ea21b7e947d6e9f8c"}}, "title": "Symptoms of depression and anxiety among elite high school student-athletes in Sweden during the COVID-19 pandemic: A repeated cross-sectional study.", "authors": [{"family": "Andersson", "given": "Mitchell J", "initials": "MJ", "orcid": "0000-0002-4753-016X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/574c35f21dad4cdea3510e7fd446cd94.json"}}, {"family": "Kentt\u00e4", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0002-9921-6586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bd3e6dbe34a41eaad16944e0de23c70.json"}}, {"family": "Moesch", "given": "Karin", "initials": "K", "orcid": "0000-0001-6500-182X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/339f5d2f86d94553b0c95483ab7f832c.json"}}, {"family": "Borg", "given": "Elisabet", "initials": "E", "orcid": "0000-0002-7638-347X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/222e6cd7574241d6b963df4c8e4082d1.json"}}, {"family": "Claesdotter-Knutsson", "given": "Emma", "initials": "E", "orcid": "0000-0002-6832-2482", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8738736985b40b3bdf49061f734f62f.json"}}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A", "orcid": "0000-0002-5800-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec14ecdcc0654d8ea864f64ce195752b.json"}}], "type": "journal article", "published": "2023-08-01", "journal": {"title": "J Sports Sci", "issn": "1466-447X", "issn-l": null, "volume": null, "issue": null, "pages": "1-10"}, "abstract": "The COVID-19 pandemic precipitated numerous changes in daily life, including the cancellation and restriction of sports globally. Because sports participation contributes positively to the development of student-athletes, restricting these activities may have led to long-term mental health changes in this population. Using a repeated cross-sectional study design, we measured rates of depression using the Patient Health Questionnaire-2 and anxiety using the Generalized Anxiety Disorder-2 scale in student-athletes attending elite sport high schools in Sweden during the second wave of the pandemic (February 2021; n = 7021) and after all restrictions were lifted (February 2022; n = 6228). Depression among student-athletes decreased from 19.8% in 2021 to 17.8% in 2022 (p = .008, V = .026), while anxiety screening did not change significantly (17.4% to 18.4%, p > .05). Comparisons between classes across years revealed older students exhibited decreases in depressive symptoms, while younger cohorts experienced increases in symptoms of anxiety from 2021 to 2022. Logistic regressions revealed that being female, reporting poorer mental health due to COVID-19, and excessive worry over one's career in sports were significant predictors of both depression and anxiety screenings in 2022. Compared to times when sports participation was limited, the lifting of restrictions was associated with overall reduced levels of depression, but not anxiety.", "doi": "10.1080/02640414.2023.2241783", "pmid": "37527354", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:26:06.817Z", "modified": "2023-10-06T04:46:42.217Z"}, {"entity": "publication", "iuid": "9fe286063aa7428b9c72813afeff6bf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9fe286063aa7428b9c72813afeff6bf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9fe286063aa7428b9c72813afeff6bf3"}}, "title": "COVID-19 vaccine hesitancy among first-generation immigrants living in Sweden.", "authors": [{"family": "Svallfors", "given": "Signe", "initials": "S", "orcid": "0000-0002-8413-1731", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2f5b34aae664a159d64182ad0f6517c.json"}}, {"family": "Larsson", "given": "Elin C", "initials": "EC"}, {"family": "Puranen", "given": "Bi", "initials": "B"}, {"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM"}], "type": "journal article", "published": "2023-08-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": "33", "issue": "4", "pages": "687-694"}, "abstract": "In many countries, immigrants face higher risks of contracting and dying from COVID-19 compared with the native-born population. Moreover, their COVID-19 vaccination uptake tends to be lower. This study aimed to investigate COVID-19 vaccine hesitancy in relation to sociodemographic characteristics, COVID-19-related exposures and social values, norms and perceptions among first-generation immigrants in Sweden. Vaccine hesitancy is an important public health issue to ensure protection against vaccine-preventable mortality and morbidity.\r\n\r\nNation-wide representative data were collected by the Migrant World Values Survey. Descriptive and multinomial multivariate analyses were performed to analyze vaccine hesitancy among 2612 men and women aged \u226516 years.\r\n\r\nOne-quarter of the respondents expressed some degree of vaccine hesitancy; 5% said they would definitely not vaccinate, 7% probably not, 4% did not know and 7% did not want to answer. Young age, arriving to Sweden during the large migration wave in 2015, Eastern European origin, female gender, lower education and low trust in authorities, and less perceived benefits of vaccination were all significant determinants of vaccine hesitancy.\r\n\r\nThe results underscore the importance of trust in healthcare providers and government authorities. Additionally, the importance of providing adequate and targeted information about vaccination to groups who face the largest barriers to care, enabling informed decision-making about the benefits and risks of vaccination in relation to health risks. Given these health risks, it is crucial that government agencies and the health sector address the multiple social dimensions that shape the low vaccine uptake and, in turn, health equity.", "doi": "10.1093/eurpub/ckad073", "pmid": "37229599", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10395762"}, {"db": "pii", "key": "7179915"}], "notes": [], "created": "2023-10-04T05:09:41.008Z", "modified": "2023-10-04T06:05:56.142Z"}, {"entity": "publication", "iuid": "5a7add59b3cd4d1c9ddce8fc1b59912e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5a7add59b3cd4d1c9ddce8fc1b59912e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5a7add59b3cd4d1c9ddce8fc1b59912e"}}, "title": "Were cancer patients worse off than the general population during the COVID-19 pandemic? A population-based study from Norway, Denmark and Iceland during the pre-vaccination era.", "authors": [{"family": "Johansson", "given": "Anna L V", "initials": "ALV"}, {"family": "Skog", "given": "Anna", "initials": "A"}, {"family": "Johannesen", "given": "Tom B\u00f8rge", "initials": "TB"}, {"family": "Myklebust", "given": "Tor \u00c5ge", "initials": "T\u00c5"}, {"family": "Skovlund", "given": "Charlotte Wessel", "initials": "CW"}, {"family": "M\u00f8rch", "given": "Lina Steinrud", "initials": "LS"}, {"family": "Friis", "given": "S\u00f8ren", "initials": "S"}, {"family": "Gamborg", "given": "Mads", "initials": "M"}, {"family": "Kristiansen", "given": "Marnar Fr\u00ed\u00f0heim", "initials": "MF"}, {"family": "Pettersson", "given": "David", "initials": "D"}, {"family": "\u00d3lafsd\u00f3ttir", "given": "El\u00ednborg J", "initials": "EJ"}, {"family": "Birgisson", "given": "Helgi", "initials": "H"}, {"family": "Palsson", "given": "Runolfur", "initials": "R"}, {"family": "Eythorsson", "given": "Elias", "initials": "E"}, {"family": "Irenaeus", "given": "Sandra", "initials": "S"}, {"family": "Lambe", "given": "Mats", "initials": "M"}, {"family": "Ursin", "given": "Giske", "initials": "G"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "issn-l": null, "volume": "31", "issue": null, "pages": "100680"}, "abstract": "In a population-based setting, we investigated the risks of testing positive for SARS-CoV-2 and developing severe COVID-19 outcomes among cancer patients compared with the general population.\r\n\r\nIn nationwide cohorts, we identified all individuals in Norway, Denmark and Iceland who tested positive for SARS-CoV-2 or had a severe COVID-19 outcome (hospitalisation, intensive care, and death) from March until December 2020, using data from national health registries. We estimated standardised incidence ratios (SIRs) with 95% confidence intervals (CIs) comparing cancer patients with the general population.\r\n\r\nDuring the first wave of the pandemic, cancer patients in Norway and Denmark had higher risks of testing SARS-CoV-2 positive compared to the general population. Throughout 2020, recently treated cancer patients were more likely to test SARS-CoV-2 positive. In Iceland, cancer patients experienced no increased risk of testing positive. The risk of COVID-19-related hospitalisation was higher among cancer patients diagnosed within one year of hospitalisation (Norway: SIR = 2.43, 95% CI 1.89-3.09; Denmark: 2.23, 1.96-2.54) and within five years (Norway: 1.58, 1.35-1.83; Denmark: 1.54, 1.42-1.66). Risks were higher in recently treated cancer patients and in those diagnosed with haematologic malignancies, colorectal or lung cancer. Risks of COVID-19-related intensive care and death were higher among cancer patients.\r\n\r\nCancer patients were at increased risk of testing positive for SARS-CoV-2 during the first pandemic wave when testing availability was limited, while relative risks of severe COVID-19 outcomes remained increased in cancer patients throughout 2020. Recent cancer treatment and haematologic malignancy were the strongest risk factors.\r\n\r\nNordic Cancer Union.", "doi": "10.1016/j.lanepe.2023.100680", "pmid": "37547277", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10398597"}, {"db": "pii", "key": "S2666-7762(23)00099-6"}], "notes": [], "created": "2023-10-05T08:01:39.277Z", "modified": "2023-10-05T08:29:59.698Z"}, {"entity": "publication", "iuid": "be720cf5d37342279078fa4d9c77d8b5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be720cf5d37342279078fa4d9c77d8b5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be720cf5d37342279078fa4d9c77d8b5"}}, "title": "The kinetics of SARS-CoV-2 viremia in COVID-19 patients receiving remdesivir.", "authors": [{"family": "Krifors", "given": "Anders", "initials": "A", "orcid": "0000-0003-1230-0492", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea4a8b6ff4ab4b10915071a561af110e.json"}}, {"family": "Karlsson", "given": "Linda", "initials": "L"}, {"family": "Ekman", "given": "Martin", "initials": "M"}, {"family": "Lorant", "given": "Camilla", "initials": "C"}, {"family": "Skorup", "given": "Paul", "initials": "P"}], "type": "observational study", "published": "2023-08-00", "journal": {"title": "Eur J Clin Microbiol Infect Dis", "issn": "1435-4373", "issn-l": null, "volume": "42", "issue": "8", "pages": "951-958"}, "abstract": "Detection of SARS-CoV-2 RNA in serum, viremia, has been linked to disease severity and outcome. The kinetics of viremia in patients receiving remdesivir has not been thoroughly studied and could help predict treatment response and outcome. We investigated the kinetics of SARS-CoV-2 viremia and factors associated with baseline viremia, viral clearance and 30-day mortality in patients receiving remdesivir. An observational study including 378 hospitalised patients (median age 67 years, 67% male) sampled with serum SARS-CoV-2 RT-PCR within \u00b1 24 h of initiation of remdesivir treatment. Baseline viremia was present in 206 (54%) patients with a median Ct value of 35.3 (IQR = 33.3-37.1). In patients with baseline viremia, the estimated probability of viral clearance was 72% by day 5. Ct values decreased significantly during remdesivir treatment for viremic patients, indicating an increase in viral load. In total, 44 patients (12%) died within 30 days, and mortality was significantly associated with viremia at baseline (OR = 2.45, p = 0.01) and lack of viral clearance by day 5 (OR = 4.8, p = < 0.01). Viral clearance was not associated with any individual risk factor. Viremia appears to be a prognostic marker before and during remedesivir treatment. The resolution of viremia was similar to patients not receiving remdesivir in other studies, and the decrease in Ct values during treatment questions the antiviral capacity of remdesivir in vivo. Prospective studies are warranted to confirm our findings.", "doi": "10.1007/s10096-023-04627-4", "pmid": "37243828", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10224642"}, {"db": "pii", "key": "10.1007/s10096-023-04627-4"}], "notes": [], "created": "2023-10-04T05:11:26.703Z", "modified": "2023-10-04T07:12:25.753Z"}, {"entity": "publication", "iuid": "79763b12a76d49b1b9f24d19c77829db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79763b12a76d49b1b9f24d19c77829db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79763b12a76d49b1b9f24d19c77829db"}}, "title": "Spontaneous Resolution of Uncomplicated Appendicitis may Explain Increase in Proportion of Complicated Appendicitis During Covid-19 Pandemic: a Systematic Review and Meta-analysis.", "authors": [{"family": "Andersson", "given": "Roland E", "initials": "RE", "orcid": "0000-0002-1460-0248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/63ebde95890245d58691f0d69acbbcc5.json"}}, {"family": "Agiorgiti", "given": "Maria", "initials": "M"}, {"family": "Bendtsen", "given": "Marcus", "initials": "M"}], "type": "meta-analysis", "published": "2023-08-00", "journal": {"title": "World J Surg", "issn": "1432-2323", "issn-l": null, "volume": "47", "issue": "8", "pages": "1901-1916"}, "abstract": "Reports of an increased proportion of complicated appendicitis during the Covid-19 pandemic suggest a worse outcome due to delay secondary to the restrained access to health care, but may be explained by a concomitant decrease in uncomplicated appendicitis. We analyze the impact of the pandemic on the incidences of complicated and uncomplicated appendicitis.\r\n\r\nWe did a systematic literature search in the PubMed, Embase and Web Of Science databases on December 21, 2022 with the search terms (appendicitis OR appendectomy) AND (\"COVID\" OR SARS-Cov2 OR \"coronavirus\"). Studies reporting the number of complicated and uncomplicated appendicitis during identical calendar periods in 2020 and the pre-pandemic year(s) were included. Reports with indications suggesting a change in how the patients were diagnosed and managed between the two periods were excluded. No protocol was prepared in advance. We did random effects meta-analysis of the change in proportion of complicated appendicitis, expressed as the risk ratio (RR), and of the change in number of patients with complicated and uncomplicated appendicitis during the pandemic compared with pre-pandemic periods, expressed as the incidence ratio (IR). We did separate analyses for studies based on single- and multi-center and regional data, age-categories and prehospital delay.\r\n\r\nThe meta-analysis of 100,059 patients in 63 reports from 25 countries shows an increase in the proportion of complicated appendicitis during the pandemic period (RR 1.39, 95% confidence interval (95% CI 1.25, 1.53). This was mainly explained by a decreased incidence of uncomplicated appendicitis (incidence ratio (IR) 0.66, 95% CI 0.59, 0.73). No increase in complicated appendicitis was seen in multi-center and regional reports combined (IR 0.98, 95% CI 0.90, 1.07).\r\n\r\nThe increased proportion of complicated appendicitis during Covid-19 is explained by a decrease in the incidence of uncomplicated appendicitis, whereas the incidence of complicated appendicitis remained stable. This result is more evident in the multi-center and regional based reports. This suggests an increase in spontaneously resolving appendicitis due to the restrained access to health care. This has important principal implications for the management of patients with suspected appendicitis.", "doi": "10.1007/s00268-023-07027-z", "pmid": "37140609", "labels": {"Category: Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC10158710"}, {"db": "pii", "key": "10.1007/s00268-023-07027-z"}], "notes": [], "created": "2023-10-04T05:11:43.715Z", "modified": "2023-10-04T07:21:04.378Z"}, {"entity": "publication", "iuid": "5f91d408d52142f4b03f19b0f95c8e51", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f91d408d52142f4b03f19b0f95c8e51.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f91d408d52142f4b03f19b0f95c8e51"}}, "title": "Revisiting the personal protective equipment components of transmission-based precautions for the prevention of COVID-19 and other respiratory virus infections in healthcare.", "authors": [{"family": "Plachouras", "given": "Diamantis", "initials": "D"}, {"family": "Kacelnik", "given": "Oliver", "initials": "O"}, {"family": "Rodr\u00edguez-Ba\u00f1o", "given": "Jes\u00fas", "initials": "J"}, {"family": "Birgand", "given": "Gabriel", "initials": "G"}, {"family": "Borg", "given": "Michael A", "initials": "MA"}, {"family": "Kristensen", "given": "Brian", "initials": "B"}, {"family": "Kubele", "given": "Jan", "initials": "J"}, {"family": "Lyytik\u00e4inen", "given": "Outi", "initials": "O"}, {"family": "Presterl", "given": "Elisabeth", "initials": "E"}, {"family": "Reilly", "given": "Jacqui", "initials": "J"}, {"family": "Voss", "given": "Andreas", "initials": "A"}, {"family": "Zingg", "given": "Walter", "initials": "W"}, {"family": "Suetens", "given": "Carl", "initials": "C"}, {"family": "Monnet", "given": "Dominique L", "initials": "DL"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "32", "pages": null}, "abstract": "The COVID-19 pandemic highlighted some potential limitations of transmission-based precautions. The distinction between transmission through large droplets vs aerosols, which have been fundamental concepts guiding infection control measures, has been questioned, leading to considerable variation in expert recommendations on transmission-based precautions for COVID-19. Furthermore, the application of elements of contact precautions, such as the use of gloves and gowns, is based on low-quality and inconclusive evidence and may have unintended consequences, such as increased incidence of healthcare-associated infections and spread of multidrug-resistant organisms. These observations indicate a need for high-quality studies to address the knowledge gaps and a need to revisit the theoretical background regarding various modes of transmission and the definitions of terms related to transmission. Further, we should examine the implications these definitions have on the following components of transmission-based precautions: (i) respiratory protection, (ii) use of gloves and gowns for the prevention of respiratory virus infections, (iii) aerosol-generating procedures and (iv) universal masking in healthcare settings as a control measure especially during seasonal epidemics. Such a review would ensure that transmission-based precautions are consistent and rationally based on available evidence, which would facilitate decision-making, guidance development and training, as well as their application in practice.", "doi": "10.2807/1560-7917.ES.2023.28.32.2200718", "pmid": "37561052", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10416576"}], "notes": [], "created": "2023-10-05T08:26:43.514Z", "modified": "2023-10-06T05:04:46.750Z"}, {"entity": "publication", "iuid": "ec036f75d2c84f21a9062b37be23a7bc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec036f75d2c84f21a9062b37be23a7bc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec036f75d2c84f21a9062b37be23a7bc"}}, "title": "Relative effectiveness of bivalent Original/Omicron BA.4-5 mRNA vaccine in preventing severe COVID-19 in persons 60 years and above during SARS-CoV-2 Omicron XBB.1.5 and other XBB sublineages circulation, Italy, April to June 2023.", "authors": [{"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Sacco", "given": "Chiara", "initials": "C"}, {"family": "Rota", "given": "Maria Cristina", "initials": "MC"}, {"family": "Fotakis", "given": "Emmanouil Alexandros", "initials": "EA"}, {"family": "Petrone", "given": "Daniele", "initials": "D"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Siddu", "given": "Andrea", "initials": "A"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Rezza", "given": "Giovanni", "initials": "G"}, {"family": "Palamara", "given": "Anna Teresa", "initials": "AT"}, {"family": "Brusaferro", "given": "Silvio", "initials": "S"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Italian Integrated Surveillance of COVID-19 study group and of the Italian COVID-19 Vaccines Registry group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "32", "pages": null}, "abstract": "During predominant circulation of SARS-CoV-2 Omicron XBB.1.5 and other XBB sublineages (April-June 2023), we found that a second or third booster of Comirnaty bivalent Original/Omicron BA.4-5 mRNA vaccine, versus a first booster received at least 120 days earlier, was effective in preventing severe COVID-19 for more than 6 months post-administration in persons 60 years and above. In view of autumn 2023 vaccination campaigns, use of bivalent Original/Omicron BA.4-5 mRNA vaccines might be warranted until monovalent COVID-19 vaccines targeting Omicron XBB.1 sublineages become available.", "doi": "10.2807/1560-7917.ES.2023.28.32.2300397", "pmid": "37561053", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10416574"}], "notes": [], "created": "2023-10-05T08:01:48.314Z", "modified": "2023-10-05T08:35:00.591Z"}, {"entity": "publication", "iuid": "60c4d930bc3a4ff78361a04cabad8596", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60c4d930bc3a4ff78361a04cabad8596.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60c4d930bc3a4ff78361a04cabad8596"}}, "title": "Real-world assessment of immunogenicity in immunocompromised individuals following SARS-CoV-2 mRNA vaccination: a one-year follow-up of the prospective clinical trial COVAXID.", "authors": [{"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Mielke", "given": "Stephan", "initials": "S"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "S\u00f6derdahl", "given": "Gunnar", "initials": "G"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE"}, {"family": "Vesterbacka", "given": "Jan", "initials": "J"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": "94", "issue": null, "pages": "104700"}, "abstract": "Immunocompromised patients have varying responses to SARS-CoV-2 mRNA vaccination. However, there is limited information available from prospective clinical trial cohorts with respect to long-term immunogenicity-related responses in these patient groups following three or four vaccine doses, and in applicable cases infection.\r\n\r\nIn a real-world setting, we assessed the long-term immunogenicity-related responses in patients with primary and secondary immunodeficiencies from the prospective open-label clinical trial COVAXID. The original clinical trial protocol included two vaccine doses given on days 0 and 21, with antibody titres measured at six different timepoints over six months. The study cohort has subsequently been followed for one year with antibody responses evaluated in relation to the third and fourth vaccine dose, and in applicable cases SARS-CoV-2 infection. In total 356/539 patients were included in the extended cohort. Blood samples were analysed for binding antibody titres and neutralisation against the Spike protein for all SARS-CoV-2 variants prevailing during the study period, including Omicron subvariants. SARS-CoV-2 infections that did not require hospital care were recorded through quarterly in-person, or phone-, interviews and assessment of IgG antibody titres against SARS-CoV-2 Nucleocapsid. The original clinical trial was registered in EudraCT (2021-000175-37) and clinicaltrials.gov (NCT04780659).\r\n\r\nThe third vaccine dose significantly increased Spike IgG titres against all the SARS-CoV-2 variants analysed in all immunocompromised patient groups. Similarly, neutralisation also increased against all variants studied, except for Omicron. Omicron-specific neutralisation, however, increased after a fourth dose as well as after three doses and infection in many of the patient subgroups. Noteworthy, however, while many patient groups mounted strong serological responses after three and four vaccine doses, comparably weak responders were found among patient subgroups with specific primary immunodeficiencies and subgroups with immunosuppressive medication.\r\n\r\nThe study identifies particularly affected patient groups in terms of development of long-term immunity among a larger group of immunocompromised patients. In particular, the results highlight poor vaccine-elicited neutralising responses towards Omicron subvariants in specific subgroups. The results provide additional knowledge of relevance for future vaccination strategies.\r\n\r\nThe present studies were supported by grants from the Swedish Research Council, the Knut and Alice Wallenberg Foundation, Nordstjernan AB, Region Stockholm, and Karolinska Institutet.", "doi": "10.1016/j.ebiom.2023.104700", "pmid": "37453361", "labels": {"Funder: VR": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10365982"}, {"db": "pii", "key": "S2352-3964(23)00265-7"}, {"db": "ClinicalTrials.gov", "key": "NCT04780659"}], "notes": [], "created": "2023-10-04T12:09:39.916Z", "modified": "2023-10-04T13:00:45.794Z"}, {"entity": "publication", "iuid": "d860da70e0254d6caaa6e69953ce5b58", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d860da70e0254d6caaa6e69953ce5b58.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d860da70e0254d6caaa6e69953ce5b58"}}, "title": "Protection against COVID-19 hospitalisation conferred by primary-series vaccination with AZD1222 in non-boosted individuals: first vaccine effectiveness results of the European COVIDRIVE study and meta-regression analysis.", "authors": [{"family": "Meeraus", "given": "Wilhelmine", "initials": "W"}, {"family": "de Munter", "given": "Leonie", "initials": "L"}, {"family": "Gray", "given": "Christen M", "initials": "CM"}, {"family": "Dwivedi", "given": "Akshat", "initials": "A"}, {"family": "Wyndham-Thomas", "given": "Chlo\u00e9", "initials": "C"}, {"family": "Ouwens", "given": "Mario", "initials": "M"}, {"family": "Hartig-Merkel", "given": "Wendy", "initials": "W"}, {"family": "Drikite", "given": "Laura", "initials": "L"}, {"family": "Rebry", "given": "Griet", "initials": "G"}, {"family": "Carmona", "given": "Antonio", "initials": "A"}, {"family": "Stuurman", "given": "Anke L", "initials": "AL"}, {"family": "Chi Nguyen", "given": "Thi Yen", "initials": "TY"}, {"family": "Mena", "given": "Guillermo", "initials": "G"}, {"family": "Mira-Iglesias", "given": "Ainara", "initials": "A"}, {"family": "Icardi", "given": "Giancarlo", "initials": "G"}, {"family": "Otero-Romero", "given": "Susana", "initials": "S"}, {"family": "Baumgartner", "given": "Sebastian", "initials": "S"}, {"family": "Martin", "given": "Charlotte", "initials": "C"}, {"family": "Taylor", "given": "Sylvia", "initials": "S"}, {"family": "Bollaerts", "given": "Kaatje", "initials": "K"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "issn-l": null, "volume": "31", "issue": null, "pages": "100675"}, "abstract": "Vaccine effectiveness (VE) studies with long-term follow-up are needed to understand durability of protection against severe COVID-19 outcomes conferred by primary-series vaccination in individuals not receiving boosters. COVIDRIVE is a European public-private partnership evaluating brand-specific vaccine effectiveness (VE). We report a prespecified interim analysis of primary-series AZD1222 (ChAdOx1 nCoV-19) VE.\r\n\r\nSeven Study Contributors in Europe collected data on individuals aged \u226518 years who were hospitalised with severe acute respiratory infection (June 1st, 2021-September 5th, 2022) and eligible for COVID-19 vaccination prior to hospitalisation. In this test-negative case-control study, individuals were defined as test-positive cases or test-negative controls (SARS-CoV-2 RT-PCR) and were either fully vaccinated (two AZD1222 doses, 4-12 weeks apart, completed \u226514 days prior to symptom onset; no booster doses) or unvaccinated (no COVID-19 vaccine prior to hospitalisation). The primary objective was to estimate AZD1222 VE against COVID-19 hospitalisation. A literature review and meta-regression were conducted to contextualise findings on durability of protection.\r\n\r\n761 individuals were included during the 15-month analysis period. Overall AZD1222 VE estimate was 72.8% (95% CI, 53.4-84.1). VE was 93.8% (48.6-99.3) in participants who received second AZD1222 doses \u22648 weeks prior to hospitalisation, with spline-based VE estimates demonstrating protection (VE \u2265 50%) 30 weeks post-second dose. Meta-regression analysis (data from seven publications) showed consistent results, with \u226580% protection against COVID-19 hospitalisation through \u223c43 weeks post-second dose, with some degree of waning.\r\n\r\nPrimary-series AZD1222 vaccination confers protection against COVID-19 hospitalisation with enduring levels of VE through \u22656 months.\r\n\r\nAstraZeneca.", "doi": "10.1016/j.lanepe.2023.100675", "pmid": "37547274", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10398604"}, {"db": "pii", "key": "S2666-7762(23)00094-7"}], "notes": [], "created": "2023-10-05T08:02:31.126Z", "modified": "2023-10-05T08:45:16.573Z"}, {"entity": "publication", "iuid": "6aff3364f8b246b88231e72ccb1373f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6aff3364f8b246b88231e72ccb1373f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6aff3364f8b246b88231e72ccb1373f2"}}, "title": "Professional ethics for infectious disease control: moral conflict management in modern public health practice.", "authors": [{"family": "Timpka", "given": "Toomas", "initials": "T"}, {"family": "Nyce", "given": "James M", "initials": "JM"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Public Health", "issn": "1476-5616", "issn-l": null, "volume": "221", "issue": null, "pages": "160-165"}, "abstract": "Despite scientific evidence that confirms their effectiveness, use of vaccines and microbiological mass testing during the COVID-19 pandemic has been associated with social and moral controversies. In this commentary, it is suggested how such conflicts originating from moral/normative imperatives can be managed in infectious disease control.\r\n\r\nThis was a commentary analysis.\r\n\r\nA case example of scientific and public debate regarding infectious disease control and policy-making during the early pandemic response is first presented. The case is used to characterize how conflicts arising from moral constraints occurred during the COVID-19 pandemic. These features are thereafter used as a basis for outlining a strategy for moral conflict prevention and management.\r\n\r\nA challenge for infectious disease control throughout the pandemic was how to manage persuasive initiatives originating from social forces competing with science for influence. Purposively maneuvered information distributed through social media and internet websites could predispose population factions to contest legitimate (evidence and legally based) pandemic response measures. During the pandemic, fact-based criticism of professionals responsible for infectious disease control was mixed with a critique of their moral standards and intentions so as to diminish effectiveness and credibility. Such blending could be curtailed if infectious disease control professionals are made accountable for public health decisions made in the light of prevalent scientific evidence and legislation.\r\n\r\nIf the infectious disease control community would embrace the international code of medical professional ethics, this would help to deal with moral conflicts, especially ones arising from external threats, in modern public health.", "doi": "10.1016/j.puhe.2023.06.017", "pmid": "37463550", "labels": {"Funder: VR": null, "Category: Health": null, "Category: Public Health": null, "Category: Vaccines": null, "Type: Review": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0033-3506(23)00206-8"}], "notes": [], "created": "2023-10-04T12:09:56.263Z", "modified": "2023-10-04T13:05:52.361Z"}, {"entity": "publication", "iuid": "d73e293cf7c34f7c9502549f02659114", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d73e293cf7c34f7c9502549f02659114.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d73e293cf7c34f7c9502549f02659114"}}, "title": "Prevalence of COVID-19 vaccine acceptance among migrant and refugee groups: A systematic review and meta-analysis.", "authors": [{"family": "Alimoradi", "given": "Zainab", "initials": "Z"}, {"family": "Sallam", "given": "Malik", "initials": "M"}, {"family": "Jafari", "given": "Elahe", "initials": "E"}, {"family": "Potenza", "given": "Marc N", "initials": "MN"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Vaccine X", "issn": "2590-1362", "issn-l": null, "volume": "14", "issue": null, "pages": "100308"}, "abstract": "Understanding COVID-19 vaccine hesitancy among migrant and refugee groups is critical for achieving vaccine equity. Therefore, we aimed to estimate the prevalence of COVID-19 vaccine acceptance among migrant and refugee populations.\r\n\r\nA systematic review (PROSPERO: CRD42022333337) was conducted (December 2019-July 2022) using PubMed, Scopus, Web of Science, ProQuest and Google Scholar.\r\n\r\nNineteen studies from 12 countries were included. The pooled estimated prevalence of COVID-19 vaccine willingness among migrant and refugee groups was 70% (19 studies, 95% CI: 62.3-77.4%, I2: 99.19%, \u03c42: 0.03). Female and male participants did not differ significantly with each other (p = 0.64). Although no individual variable contributed statistically significantly in multivariable meta-regression analysis, the multivariable model that considered methodological quality, mean age of participants, participant group and country of origin explained 67% of variance.\r\n\r\nProportions of migrant/refugee groups receiving COVID-19 vaccinations approximated those observed among general populations. Additional studies are needed to examine factors relating to vaccine willingness to identify the most significant factors that may be targeted in interventions.", "doi": "10.1016/j.jvacx.2023.100308", "pmid": "37223070", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10163798"}, {"db": "pii", "key": "S2590-1362(23)00049-9"}], "notes": [], "created": "2023-10-04T05:10:36.538Z", "modified": "2023-10-04T06:46:36.308Z"}, {"entity": "publication", "iuid": "ccc94b53992b4ba1aed223a6e2656d3e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ccc94b53992b4ba1aed223a6e2656d3e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ccc94b53992b4ba1aed223a6e2656d3e"}}, "title": "Local and Systemic Immunity During Five Vaccinations Against SARS-CoV-2 in Zanubrutinib-Treated Patients With Chronic Lymphocytic Leukemia.", "authors": [{"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Wu", "given": "Jinghua", "initials": "J"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Aberg", "given": "Mikael", "initials": "M"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "Naud", "given": "Sabrina", "initials": "S"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Palma", "given": "Marzia", "initials": "M"}, {"family": "Mellstedt", "given": "Hakan", "initials": "H"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Sallberg Chen", "given": "Margaret", "initials": "M"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Ingelman-Sundberg", "given": "Hanna M", "initials": "HM"}, {"family": "Osterborg", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "J Hematol", "issn": "1927-1220", "issn-l": null, "volume": "12", "issue": "4", "pages": "170-175"}, "abstract": "Patients with chronic lymphocytic leukemia (CLL) are vulnerable to coronavirus disease 2019 (COVID-19) and are at risk of inferior response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination, especially if treated with the first-generation Bruton's tyrosine kinase inhibitor (BTKi) ibrutinib. We aimed to evaluate the impact of the third-generation BTKi, zanubrutinib, on systemic and mucosal response to SARS-CoV-2 vaccination.\r\n\r\nNine patients with CLL with ongoing zanubrutinib therapy were included and donated blood and saliva during SARS-CoV-2 vaccination, before vaccine doses 3 and 5 and 2 - 3 weeks after doses 3, 4, and 5. Ibrutinib-treated control patients (n = 7) and healthy aged-matched controls (n = 7) gave blood 2 - 3 weeks after vaccine dose 5. We quantified reactivity and neutralization capacity of SARS-CoV-2-specific IgG and IgA antibodies (Abs) in both serum and saliva, and reactivity of T cells activated with viral peptides.\r\n\r\nBoth zanubrutinib- and ibrutinib-treated patients had significantly, up to 1,000-fold, lower total spike-specific Ab levels after dose 5 compared to healthy controls (P < 0.01). Spike-IgG levels in serum from zanubrutinib-treated patients correlated well to neutralization capacity (r = 0.68; P < 0.0001) and were thus functional. Mucosal immunity (specific IgA in serum and saliva) was practically absent in zanubrutinib-treated patients even after five vaccine doses, whereas healthy controls had significantly higher levels (tested in serum after vaccine dose 5) (P < 0.05). In contrast, T-cell reactivity against SARS-CoV-2 peptides was equally high in zanubrutinib- and ibrutinib-treated patients as in healthy control donors.\r\n\r\nIn our small cohort of zanubrutinib-treated CLL patients, we conclude that up to five doses of SARS-CoV-2 vaccination induced no detectable IgA mucosal immunity, which likely will impair the primary barrier defence against the infection. Systemic IgG responses were also impaired, whereas T-cell responses were normal. Further and larger studies are needed to evaluate the impact of these findings on disease protection.", "doi": "10.14740/jh1140", "pmid": "37692865", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10482612"}], "notes": [], "created": "2023-10-06T06:52:48.781Z", "modified": "2023-10-06T09:56:27.790Z"}, {"entity": "publication", "iuid": "12974aeee56640e7b04a0fe610c40f4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/12974aeee56640e7b04a0fe610c40f4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/12974aeee56640e7b04a0fe610c40f4c"}}, "title": "Living alone and mental health: parallel analyses in UK longitudinal population surveys and electronic health records prior to and during the COVID-19 pandemic.", "authors": [{"family": "McElroy", "given": "Eoin", "initials": "E", "orcid": "0000-0001-5466-8522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf4d10d067cd401896f2e1d5d5407f41.json"}}, {"family": "Herrett", "given": "Emily", "initials": "E", "orcid": "0000-0002-9425-644X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff5906d75a654724bba356031a4394e8.json"}}, {"family": "Patel", "given": "Kishan", "initials": "K", "orcid": "0000-0002-5693-6831", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4edb8e82fdf4c60874bad3eb9ceb6bc.json"}}, {"family": "Piehlmaier", "given": "Dominik M", "initials": "DM", "orcid": "0000-0003-0229-7007", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3957625c2ee04099a46f9b34334516d9.json"}}, {"family": "Gessa", "given": "Giorgio Di", "initials": "GD", "orcid": "0000-0001-6154-1845", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c2319c222cc40069a5f55ead6d361f6.json"}}, {"family": "Huggins", "given": "Charlotte", "initials": "C", "orcid": "0000-0001-5960-4771", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a02a696d498246b78636287e668394c8.json"}}, {"family": "Green", "given": "Michael J", "initials": "MJ", "orcid": "0000-0003-3193-2452", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84efba4af3264153b510906d0f4dcb35.json"}}, {"family": "Kwong", "given": "Alex S F", "initials": "ASF", "orcid": "0000-0003-1953-2771", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65ccb94351224dbdbcaa53d6ef6502ba.json"}}, {"family": "Thompson", "given": "Ellen J", "initials": "EJ", "orcid": "0000-0003-2118-821X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6754739394b24a5c8f5db22905b22c3c.json"}}, {"family": "Zhu", "given": "Jingmin", "initials": "J", "orcid": "0000-0001-8325-7589", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2ea57fd9f164a4687613cc7692ec378.json"}}, {"family": "Mansfield", "given": "Kathryn E", "initials": "KE"}, {"family": "Silverwood", "given": "Richard J", "initials": "RJ", "orcid": "0000-0002-2744-1194", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d46ad9468444d3dbfbe8f392b9fb502.json"}}, {"family": "Mansfield", "given": "Rosie", "initials": "R"}, {"family": "Maddock", "given": "Jane", "initials": "J", "orcid": "0000-0002-7975-4221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96323411c0b4423bb94776fea40f3f79.json"}}, {"family": "Mathur", "given": "Rohini", "initials": "R", "orcid": "0000-0002-3817-8790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/413a53b2b6734b6983ce583bf8ae9849.json"}}, {"family": "Costello", "given": "Ruth E", "initials": "RE", "orcid": "0000-0003-2709-6666", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c0fe69f61b54ab89f9a3de852f872a8.json"}}, {"family": "Matthews", "given": "Anthony", "initials": "A"}, {"family": "Tazare", "given": "John", "initials": "J", "orcid": "0000-0002-7194-2615", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/edd71baff18241099ed99c9770b9aad6.json"}}, {"family": "Henderson", "given": "Alasdair", "initials": "A", "orcid": "0000-0002-8903-4906", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/136c2cef770547d9a777c334746755a7.json"}}, {"family": "Wing", "given": "Kevin", "initials": "K", "orcid": "0000-0003-2335-9641", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a5697cdb0ed469091230d744f22a31c.json"}}, {"family": "Bridges", "given": "Lucy", "initials": "L", "orcid": "0000-0002-4407-9596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07faf17819de4a219027db6f265bad97.json"}}, {"family": "Bacon", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-6354-3454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6616a304a007470e8fce5b54c5874156.json"}}, {"family": "Mehrkar", "given": "Amir", "initials": "A", "orcid": "0000-0002-2098-1278", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee1d683bf7114dc8a4deace10b1cd4ce.json"}}, {"family": "OpenSAFELY Collaborative", "given": "", "initials": ""}, {"family": "Shaw", "given": "Richard John", "initials": "RJ", "orcid": "0000-0002-7906-6066", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e70bea99a7b44fbeaa9841571db846a3.json"}}, {"family": "Wels", "given": "Jacques", "initials": "J", "orcid": "0000-0002-9292-917X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03eb758b02f04c3583536497f996ea68.json"}}, {"family": "Katikireddi", "given": "Srinivasa Vittal", "initials": "SV", "orcid": "0000-0001-6593-9092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9bcdfb6c28e742878e7df8ee66fa6863.json"}}, {"family": "Chaturvedi", "given": "Nish", "initials": "N", "orcid": "0000-0002-6211-2775", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94889a94593342f688fc89e9419ef7d0.json"}}, {"family": "Tomlinson", "given": "Laurie A", "initials": "LA", "orcid": "0000-0001-8848-9493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03f2034f701e46f3919a944d2ac325d7.json"}}, {"family": "Patalay", "given": "Praveetha", "initials": "P", "orcid": "0000-0002-5341-3461", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c768af96078f4a0f9dc121d07bef6f81.json"}}, {"family": "Longitudinal Health and Wellbeing Collaborative", "given": "", "initials": ""}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "BMJ Ment Health", "issn": "2755-9734", "issn-l": null, "volume": "26", "issue": "1", "pages": null}, "abstract": "People who live alone experience greater levels of mental illness; however, it is unclear whether the COVID-19 pandemic had a disproportionately negative impact on this demographic.\r\n\r\nTo describe the mental health gap between those who live alone and with others in the UK prior to and during the COVID-19 pandemic.\r\n\r\nSelf-reported psychological distress and life satisfaction in 10 prospective longitudinal population surveys (LPSs) assessed in the nearest pre-pandemic sweep and three periods during the pandemic. Recorded diagnosis of common and severe mental illnesses between March 2018 and January 2022 in electronic healthcare records (EHRs) within the OpenSAFELY-TPP.\r\n\r\nIn 37 544 LPS participants, pooled models showed greater psychological distress (standardised mean difference (SMD): 0.09 (95% CI: 0.04; 0.14); relative risk: 1.25 (95% CI: 1.12; 1.39)) and lower life satisfaction (SMD: -0.22 (95% CI: -0.30; -0.15)) for those living alone pre-pandemic. This gap did not change during the pandemic. In the EHR analysis of c.16 million records, mental health conditions were more common in those who lived alone (eg, depression 26 (95% CI: 18 to 33) and severe mental illness 58 (95% CI: 54 to 62) more cases more per 100 000). For common mental health disorders, the gap in recorded cases in EHRs narrowed during the pandemic.\r\n\r\nPeople living alone have poorer mental health and lower life satisfaction. During the pandemic, this gap in self-reported distress remained; however, there was a narrowing of the gap in service use.\r\n\r\nGreater mental health need and potentially greater barriers to mental healthcare access for those who live alone need to be considered in healthcare planning.", "doi": "10.1136/bmjment-2023-300842", "pmid": "37562853", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pii", "key": "bmjment-2023-300842"}], "notes": [], "created": "2023-10-05T08:26:51.207Z", "modified": "2023-10-06T05:16:12.883Z"}, {"entity": "publication", "iuid": "fa914e711dd04aa88bad9970b0bea1f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa914e711dd04aa88bad9970b0bea1f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa914e711dd04aa88bad9970b0bea1f0"}}, "title": "Impact of asthma in Europe: A comparison of web search data in 21 European countries.", "authors": [{"family": "Wecker", "given": "Hannah", "initials": "H"}, {"family": "Tizek", "given": "Linda", "initials": "L"}, {"family": "Ziehfreund", "given": "Stefanie", "initials": "S"}, {"family": "Kain", "given": "Alphina", "initials": "A"}, {"family": "Traidl-Hoffmann", "given": "Claudia", "initials": "C"}, {"family": "Zimmermann", "given": "Gregor S", "initials": "GS"}, {"family": "Scala", "given": "Emanuele", "initials": "E"}, {"family": "Elberling", "given": "Jesper", "initials": "J"}, {"family": "Doll", "given": "Ana\u00efs", "initials": "A"}, {"family": "Boffa", "given": "Michael J", "initials": "MJ"}, {"family": "Schmidt", "given": "Lea", "initials": "L"}, {"family": "Sikora", "given": "Mariusz", "initials": "M"}, {"family": "Torres", "given": "Tiago", "initials": "T"}, {"family": "Ballardini", "given": "Natalia", "initials": "N"}, {"family": "Chernyshov", "given": "Pavel V", "initials": "PV"}, {"family": "Buters", "given": "Jeroen", "initials": "J"}, {"family": "Biedermann", "given": "Tilo", "initials": "T"}, {"family": "Zink", "given": "Alexander", "initials": "A"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "World Allergy Organ J", "issn": "1939-4551", "issn-l": "1939-4551", "volume": "16", "issue": "8", "pages": "100805"}, "abstract": "Asthma is a chronic inflammatory disorder of the airways and one of the most important non-communicable diseases worldwide. Analyzing crowdsourced data can help understand public interest and unmet needs as well as potential factors influencing search behavior.\r\n\r\nThe study aimed to investigate asthma-related web search data in Europe to identify possible regional and seasonal variations and to assess public interest.\r\n\r\nGoogle Ads Keyword Planner was used to measure search volume for search terms related to asthma, allergic asthma, and bronchial asthma in 21 European countries between January 2018 and December 2021. The top 10 keywords of each country were categorized qualitatively. Search volume per 100 000 inhabitants was descriptively assessed in terms of regional and seasonal trends. Spearman correlations between search volume and pollen concentration as well as coronavirus disease (COVID-19) cases were investigated.\r\n\r\nThe median search volume per 100 000 inhabitants for asthma and allergic asthma was highest in Northern and Western Europe, while the highest search volume for bronchial asthma was observed in Western and Eastern regions. A seasonal trend was identified for all search terms and in all regions. Correlations were found between search frequency and pollen load and search behavior and COVID-19 cases. Overall, Europeans were most interested in the diseases in general, their treatment options, and symptoms.\r\n\r\nThese results highlighted the need for reliable and region-specific information about the disease and for public campaigns to improve asthma control. The study also emphasizes the importance of using crowdsourced data for a more encompassing overview beyond conventional healthcare data.", "doi": "10.1016/j.waojou.2023.100805", "pmid": "37564904", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10410582"}, {"db": "pii", "key": "S1939-4551(23)00065-0"}], "notes": [], "created": "2023-10-05T08:26:40.891Z", "modified": "2023-10-06T05:03:14.211Z"}, {"entity": "publication", "iuid": "b0d93f664e8e4e268d06ed0166907d8a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b0d93f664e8e4e268d06ed0166907d8a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b0d93f664e8e4e268d06ed0166907d8a"}}, "title": "High Exposure to Perfluoroalkyl Substances and Antibody Responses to SARS-CoV-2 mRNA Vaccine-an Observational Study in Adults from Ronneby, Sweden.", "authors": [{"family": "Andersson", "given": "Axel G", "initials": "AG", "orcid": "0000-0002-1215-8433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/291ed3a52d1c470fad6855915a959b69.json"}}, {"family": "Lundgren", "given": "Anna", "initials": "A"}, {"family": "Xu", "given": "Yiyi", "initials": "Y"}, {"family": "Nielsen", "given": "Christel", "initials": "C"}, {"family": "Lindh", "given": "Christian H", "initials": "CH"}, {"family": "Pineda", "given": "Daniela", "initials": "D"}, {"family": "Cederlund", "given": "Julia", "initials": "J"}, {"family": "Pataridou", "given": "Elisavet", "initials": "E"}, {"family": "S\u00f8gaard T\u00f8ttenborg", "given": "Sandra", "initials": "S"}, {"family": "Ugelvig Petersen", "given": "Kajsa", "initials": "K"}, {"family": "Fletcher", "given": "Tony", "initials": "T"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Bemark", "given": "Mats", "initials": "M"}, {"family": "Jakobsson", "given": "Kristina", "initials": "K"}, {"family": "Li", "given": "Ying", "initials": "Y"}], "type": "observational study", "published": "2023-08-00", "journal": {"title": "Environ Health Perspect", "issn": "1552-9924", "issn-l": null, "volume": "131", "issue": "8", "pages": "87007"}, "abstract": "Per- and polyfluoroalkyl substances (PFAS) are widely used, environmentally ubiquitous, and stable chemicals that have been associated with lower vaccine-induced antibody responses in children; however, data on adults are limited. The drinking water from one of the two waterworks in Ronneby, Sweden, was heavily contaminated for decades with PFAS from firefighting foams, primarily perfluorohexane sulfonic acid and perfluorooctanesulfonic acid (PFOS). Vaccination against SARS-CoV-2 offered a unique opportunity to investigate antibody responses to primary vaccination in adults who had been exposed to PFAS.\r\n\r\nOur objective was to evaluate associations between PFAS, across a wide range of exposure levels, and antibody responses in adults 5 wk and 6 months after a two-dose vaccination regime against SARS-CoV-2.\r\n\r\nAdults age 20-60 y from Ronneby (, median PFOS serum level n=309, fifth to 95th percentile 47 ng/mL) and a group with background exposure (4-213 ng/mL, median PFOS serum level n=47) received two doses of the Spikevax (Moderna) mRNA vaccine. The levels of seven PFAS were measured in serum before vaccination. Serum immunoglobulin G antibodies against the SARS-CoV-2 spike antigen (S-Abs) were measured before vaccination and at 5 wk (4 ng/mL) and 6 months (n=350) after the second vaccine dose. Linear regression analyses were fitted against current, historical, and prenatal exposure to PFAS, adjusting for sex, age, and smoking, excluding individuals with previous SARS-CoV-2-infection.n=329\r\n\r\nPFAS exposure, regardless of how it was estimated, was not negatively associated with antibody levels 5 wk [current PFOS: S-Abs/PFOS interquartile range (IQR); 95% confidence interval (CI): -0.5%, 7] or 6 months (current PFOS: 3% S-Abs/PFOS IQR; 95% CI: -8, 12) after COVID-19 vaccination.-6\r\n\r\nFollowing a strict study protocol, rigorous study design, and few dropouts, we found no indication that PFAS exposure negatively affected antibody responses to COVID-19 mRNA vaccination for up to 6 months after vaccination. https://doi.org/10.1289/EHP11847.", "doi": "10.1289/EHP11847", "pmid": "37578904", "labels": {"Funder: Forte": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10424820"}, {"db": "EudraCT", "key": "2021-000842-16"}], "notes": [], "created": "2023-10-05T08:01:59.033Z", "modified": "2023-10-05T08:40:06.917Z"}, {"entity": "publication", "iuid": "5428e4b796a945bcafd9aee56df86839", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5428e4b796a945bcafd9aee56df86839.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5428e4b796a945bcafd9aee56df86839"}}, "title": "Food-related experiences and behavioral responses among people affected by chemosensory dysfunctions following COVID-19: A scoping review.", "authors": [{"family": "Neuman", "given": "Nicklas", "initials": "N", "orcid": "0000-0001-7970-4753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d135c1772d041e1af59c646a97ca9a0.json"}}, {"family": "Sandvik", "given": "Pernilla", "initials": "P"}, {"family": "Lindholm", "given": "Ninni Bellini", "initials": "NB"}, {"family": "B\u00f6mer-Schulte", "given": "Katharina", "initials": "K"}, {"family": "L\u00f6vestam", "given": "Elin", "initials": "E"}], "type": "review", "published": "2023-08-00", "journal": {"title": "Res Nurs Health", "issn": "1098-240X", "issn-l": null, "volume": "46", "issue": "4", "pages": "385-399"}, "abstract": "A category of symptoms that became characteristic early in the first wave of the coronavirus disease 2019 (COVID-19) pandemic was chemosensory dysfunctions (alterations of smell and taste). Such symptoms substantially affect food and eating-cornerstones for both nutrition-related health outcomes and for quality of life. Based on this, this scoping review aimed to map out existing scientific literature on food-related experiences and related behavioral responses among people affected by chemosensory dysfunctions following COVID-19. A librarian-supported search of PsycInfo, PubMed, and Scopus for publications written in English (2020 to April 26, 2022) was conducted. Two authors searched for and screened publications and three others extracted and collated data. These are reported following the Preferred Reporting Items of Systematic reviews and Meta-Analyses extension for Scoping Reviews. Of 1169 hits, 9 publications were included in the review. The results are thematized as \"Psychological and social aspects\" and \"Nutritional aspects,\" each with the subsections \"Experiences\" and \"Behavioral responses.\" A great variety of food-related problems, nutritional and mental health effects, and implications for social life are identified. People affected by chemosensory dysfunctions following COVID-19 suffer, as evident both in stories from qualitative studies and in measurements of quality of life. The results impact all professions who are and may come to be involved in treating these patients, such as nurses, physicians, dietitians, and psychologists. With more knowledge about the dysfunctions' manifestation, duration, and impact on everyday life, multiprofessional teams need to collaborate in supporting patients medically, psychosocially, and nutritionally.", "doi": "10.1002/nur.22315", "pmid": "37171788", "labels": {"Category: Health": null, "Type: Review": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:10:50.604Z", "modified": "2023-10-04T07:00:13.599Z"}, {"entity": "publication", "iuid": "4958e8848a3946d2be85f7443d18d7cd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4958e8848a3946d2be85f7443d18d7cd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4958e8848a3946d2be85f7443d18d7cd"}}, "title": "Effect of external dead space removal on CO2 homeostasis in mechanically ventilated adult Covid-19 patients.", "authors": [{"family": "\u00d6hman", "given": "Tomas", "initials": "T"}, {"family": "Jalde", "given": "Francesca Campoccia", "initials": "FC"}, {"family": "Fredby", "given": "Magnus", "initials": "M"}, {"family": "Bj\u00f6rne", "given": "H\u00e5kan", "initials": "H"}, {"family": "Karlsson", "given": "Jacob", "initials": "J", "orcid": "0000-0003-2277-0092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a428771f0dc41948d1d1e13131497bc.json"}}], "type": "observational study", "published": "2023-08-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": "67", "issue": "7", "pages": "936-942"}, "abstract": "Patients with Covid-19 respiratory failure present with hypoxemia, often in combination with hypercapnia. In this prospective, observational study we examined the effect of removing external dead space (DS) on CO2 -homeostasis in mechanically ventilated Covid-19 patients. In addition, volumetric capnography was validated for its ability to estimate external DS volume using in vitro measured DS volumes as reference.\r\n\r\nIn total, 10 patients with acute respiratory distress syndrome from Covid-19 were included. Volumetric capnography, mechanical ventilation, and arterial blood gas data were analyzed before and after removal of external DS and analyzed for potentially significant changes in response to DS removal. Measurements of external DS were obtained in circuit using volumetric capnography and compared to actual measured DS volumes off the circuit.\r\n\r\nAfter the removal of external DS, the alveolar minute ventilation and CO2 elimination improved, notwithstanding unchanged respiratory rate and tidal volumes. The increase in CO2 elimination was associated with a decrease in arterial CO2 partial pressure (PaCO2 ). The volumetric capnography method for assessment of external DS showed a low bias of -9 mL (lower limit of agreement -40, 95% CI -60 to -20 mL, upper limit of agreement 21 mL, 95% CI: 1-40 mL) and a percentage error of 48% compared to absolute values measured in vitro.\r\n\r\nRemoval of external DS increased alveolar minute ventilation and CO2 elimination in Covid-19 patients with respiratory failure in the current study. This was associated with a decrease in PaCO2 . This may indicate a decreased CO2 production due to decreased work of breathing and more effective gas-exchange in response to DS removal. In addition, volumetric capnography appears to be a clinically feasible method for continuous measurement of external DS in the current study and may be of value in optimizing ventilator treatment.", "doi": "10.1111/aas.14252", "pmid": "37354078", "labels": {"Category: Health": null, "Funder: Vinnova": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:31:09.191Z", "modified": "2023-10-04T10:44:03.243Z"}, {"entity": "publication", "iuid": "54c4d494ea0b4df8bacb49481ba454ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54c4d494ea0b4df8bacb49481ba454ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54c4d494ea0b4df8bacb49481ba454ff"}}, "title": "Echocardiography phenotypes of right ventricular involvement in COVID-19 ARDS patients and ICU mortality: post-hoc (exploratory) analysis of repeated data from the ECHO-COVID study.", "authors": [{"family": "Huang", "given": "Stephen", "initials": "S"}, {"family": "Vieillard-Baron", "given": "Antoine", "initials": "A"}, {"family": "Evrard", "given": "Bruno", "initials": "B", "orcid": "0000-0003-1829-4927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bba6533429b5415ab89299eda9c64d57.json"}}, {"family": "Prat", "given": "Gwena\u00ebl", "initials": "G"}, {"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Balik", "given": "Martin", "initials": "M"}, {"family": "Clau-Terr\u00e9", "given": "Fernando", "initials": "F"}, {"family": "De Backer", "given": "Daniel", "initials": "D"}, {"family": "Mekontso Dessap", "given": "Armand", "initials": "A"}, {"family": "Orde", "given": "Sam", "initials": "S"}, {"family": "Morelli", "given": "Andrea", "initials": "A"}, {"family": "Sanfilippo", "given": "Filippo", "initials": "F"}, {"family": "Charron", "given": "Cyril", "initials": "C"}, {"family": "Vignon", "given": "Philippe", "initials": "P", "orcid": "0000-0003-4551-5772", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9944b30a58047218e6e4cf59c3572b4.json"}}, {"family": "ECHO-COVID study group", "given": "", "initials": ""}], "type": "observational study", "published": "2023-08-00", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "issn-l": "0342-4642", "volume": "49", "issue": "8", "pages": "946-956"}, "abstract": "Exploratory study to evaluate the association of different phenotypes of right ventricular (RV) involvement and mortality in the intensive care unit (ICU) in patients with acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19).\r\n\r\nPost-hoc analysis of longitudinal data from the multicenter ECHO-COVID observational study in ICU patients who underwent at least two echocardiography examinations. Echocardiography phenotypes were acute cor pulmonale (ACP, RV cavity dilatation with paradoxical septal motion), RV failure (RVF, RV cavity dilatation and systemic venous congestion), and RV dysfunction (tricuspid annular plane systolic excursion \u2264 16 mm). Accelerated failure time model and multistate model were used for analysis.\r\n\r\nOf 281 patients who underwent 948 echocardiography studies during ICU stay, 189 (67%) were found to have at least 1 type of RV involvements during one or several examinations: ACP (105/281, 37.4%), RVF (140/256, 54.7%) and/or RV dysfunction (74/255, 29%). Patients with all examinations displaying ACP had survival time shortened by 0.479 [0.284-0.803] times when compared to patients with all examinations depicting no ACP (P = 0.005). RVF showed a trend towards shortened survival time by a factor of 0.642 [0.405-1.018] (P = 0.059), whereas the impact of RV dysfunction on survival time was inconclusive (P = 0.451). Multistate analysis showed that patients might transit in and out of RV involvement, and those who exhibited ACP in their last critical care echocardiography (CCE) examination had the highest risk of mortality (hazard ratio (HR) 3.25 [2.38-4.45], P < 0.001).\r\n\r\nRV involvement is prevalent in patients ventilated for COVID-19 ARDS. Different phenotypes of RV involvement might lead to different ICU mortality, with ACP having the worst outcome.", "doi": "10.1007/s00134-023-07147-z", "pmid": "37436445", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-023-07147-z"}, {"db": "ClinicalTrials.gov", "key": "NCT04414410"}], "notes": [], "created": "2023-10-04T12:10:45.208Z", "modified": "2023-10-04T13:30:45.479Z"}, {"entity": "publication", "iuid": "78855cf5737a471daf4bde2997a75b88", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/78855cf5737a471daf4bde2997a75b88.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/78855cf5737a471daf4bde2997a75b88"}}, "title": "Concordance between COVID-19 mortality statistics derived from clinical audit and death certificates in \u00d6sterg\u00f6tland county, Sweden.", "authors": [{"family": "Spreco", "given": "A", "initials": "A"}, {"family": "Andersson", "given": "C", "initials": "C"}, {"family": "Sj\u00f6dahl", "given": "R", "initials": "R"}, {"family": "Timpka", "given": "T", "initials": "T"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Public Health", "issn": "1476-5616", "issn-l": null, "volume": "221", "issue": null, "pages": "46-49"}, "abstract": "Despite early notions that correct attribution of deaths caused by SARS-CoV-2 infection is critical to the understanding of the COVID-19 pandemic, three years later, the accuracy of COVID-19 death counts is still contested. We aimed to compare official death statistics with cause-of-death assessments made in a clinical audit routine by experienced physicians having access to the full medical record.\r\n\r\nHealth service quality evaluation.\r\n\r\nIn \u00d6sterg\u00f6tland county (pop. 465,000), Sweden, a clinical audit team assessed from the start of the pandemic the cause of death in individuals having deceased after testing positive for SARS-CoV-2. We estimated the concordance between official data on COVID-19 deaths and data from the clinical audit using correlations (r) between the cause-of-death categories and discrepancies between the absolute numbers of categorised deaths.\r\n\r\nThe concordance between the data sources was poor regarding whether COVID-19 was the underlying or a contributing cause of death. Grouping of the causes increased the correlations to acceptable strength. Also including deaths implicated by a positive SARS-CoV-2 test in the clinical categorisation of COVID-19 deaths reduced the difference in absolute number of deaths; with these modifications, the concordance was acceptable before the COVID-19 vaccination program was initiated (r = 0.97; symmetric mean absolute percentage error (SMAPE) = 19%), while a difference in the absolute numbers of deaths remained in the vaccination period (r = 0.94; SMAPE = 35%).\r\n\r\nThis study highlights that carefulness is warranted when COVID-19 death statistics are used in health service planning and resonates a need for further research on cause-of-death recording methodologies.", "doi": "10.1016/j.puhe.2023.06.007", "pmid": "37399611", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10250145"}, {"db": "pii", "key": "S0033-3506(23)00196-8"}], "notes": [], "created": "2023-10-04T12:07:35.390Z", "modified": "2023-10-04T12:20:18.768Z"}, {"entity": "publication", "iuid": "03df4cb9fa074a96b65ad775b99372a7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/03df4cb9fa074a96b65ad775b99372a7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/03df4cb9fa074a96b65ad775b99372a7"}}, "title": "Collaborative nowcasting of COVID-19 hospitalization incidences in Germany.", "authors": [{"family": "Wolffram", "given": "Daniel", "initials": "D", "orcid": "0000-0003-0318-3669", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce85bc05765a499db19a3df6ec4c142b.json"}}, {"family": "Abbott", "given": "Sam", "initials": "S"}, {"family": "An der Heiden", "given": "Matthias", "initials": "M"}, {"family": "Funk", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-2842-3406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f03dcbc41884648a4eac5892852899a.json"}}, {"family": "G\u00fcnther", "given": "Felix", "initials": "F"}, {"family": "Hailer", "given": "Davide", "initials": "D"}, {"family": "Heyder", "given": "Stefan", "initials": "S"}, {"family": "Hotz", "given": "Thomas", "initials": "T"}, {"family": "van de Kassteele", "given": "Jan", "initials": "J"}, {"family": "K\u00fcchenhoff", "given": "Helmut", "initials": "H"}, {"family": "M\u00fcller-Hansen", "given": "S\u00f6ren", "initials": "S"}, {"family": "Syliqi", "given": "Diell\u00eb", "initials": "D"}, {"family": "Ullrich", "given": "Alexander", "initials": "A"}, {"family": "Weigert", "given": "Maximilian", "initials": "M", "orcid": "0000-0003-4400-134X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4022b7edbd404fa695f562f9fd78a051.json"}}, {"family": "Schienle", "given": "Melanie", "initials": "M"}, {"family": "Bracher", "given": "Johannes", "initials": "J", "orcid": "0000-0002-3777-1410", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/edf3423decee40a8835ae6475a141386.json"}}], "type": "case reports", "published": "2023-08-00", "journal": {"title": "PLoS Comput Biol", "issn": "1553-7358", "issn-l": null, "volume": "19", "issue": "8", "pages": "e1011394"}, "abstract": "Real-time surveillance is a crucial element in the response to infectious disease outbreaks. However, the interpretation of incidence data is often hampered by delays occurring at various stages of data gathering and reporting. As a result, recent values are biased downward, which obscures current trends. Statistical nowcasting techniques can be employed to correct these biases, allowing for accurate characterization of recent developments and thus enhancing situational awareness. In this paper, we present a preregistered real-time assessment of eight nowcasting approaches, applied by independent research teams to German 7-day hospitalization incidences during the COVID-19 pandemic. This indicator played an important role in the management of the outbreak in Germany and was linked to levels of non-pharmaceutical interventions via certain thresholds. Due to its definition, in which hospitalization counts are aggregated by the date of case report rather than admission, German hospitalization incidences are particularly affected by delays and can take several weeks or months to fully stabilize. For this study, all methods were applied from 22 November 2021 to 29 April 2022, with probabilistic nowcasts produced each day for the current and 28 preceding days. Nowcasts at the national, state, and age-group levels were collected in the form of quantiles in a public repository and displayed in a dashboard. Moreover, a mean and a median ensemble nowcast were generated. We find that overall, the compared methods were able to remove a large part of the biases introduced by delays. Most participating teams underestimated the importance of very long delays, though, resulting in nowcasts with a slight downward bias. The accompanying prediction intervals were also too narrow for almost all methods. Averaged over all nowcast horizons, the best performance was achieved by a model using case incidences as a covariate and taking into account longer delays than the other approaches. For the most recent days, which are often considered the most relevant in practice, a mean ensemble of the submitted nowcasts performed best. We conclude by providing some lessons learned on the definition of nowcasting targets and practical challenges.", "doi": "10.1371/journal.pcbi.1011394", "pmid": "37566642", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Other": null, "Funder: NordForsk": null}, "xrefs": [{"db": "pmc", "key": "PMC10446237"}, {"db": "pii", "key": "PCOMPBIOL-D-23-00600"}], "notes": [], "created": "2023-10-05T08:27:07.259Z", "modified": "2023-10-06T05:21:23.352Z"}, {"entity": "publication", "iuid": "280a86d0e27f4240af16b8cfe3cffbab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/280a86d0e27f4240af16b8cfe3cffbab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/280a86d0e27f4240af16b8cfe3cffbab"}}, "title": "Classification of \"Near-patient\" and \"Point-of-Care\" SARS-CoV-2 Nucleic Acid Amplification Test Systems and a first approach to evaluate their analytical independence of operator activities.", "authors": [{"family": "Buchta", "given": "Christoph", "initials": "C"}, {"family": "Zeichhardt", "given": "Heinz", "initials": "H"}, {"family": "Badrick", "given": "Tony", "initials": "T"}, {"family": "Coucke", "given": "Wim", "initials": "W"}, {"family": "Wojtalewicz", "given": "Nathalie", "initials": "N"}, {"family": "Griesmacher", "given": "Andrea", "initials": "A"}, {"family": "Aberle", "given": "Stephan W", "initials": "SW"}, {"family": "Schellenberg", "given": "Ingo", "initials": "I"}, {"family": "Jacobs", "given": "Ellis", "initials": "E"}, {"family": "Nordin", "given": "Gunnar", "initials": "G"}, {"family": "Schweiger", "given": "Christian", "initials": "C"}, {"family": "Schwenoha", "given": "Karin", "initials": "K"}, {"family": "Luppa", "given": "Peter B", "initials": "PB"}, {"family": "Gassner", "given": "Ulrich M", "initials": "UM"}, {"family": "Wagner", "given": "Thomas", "initials": "T"}, {"family": "Kammel", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "J Clin Virol", "issn": "1873-5967", "issn-l": null, "volume": "165", "issue": null, "pages": "105521"}, "abstract": "European legislation defines as \"near-patient testing\" (NPT) what is popularly and in other legislations specified as \"point-of-care testing\" (POCT). Systems intended for NPT/POCT use must be characterized by independence from operator activities during the analytic procedure. However, tools for evaluating this are lacking. We hypothesized that the variability of measurement results obtained from identical samples with a larger number of identical devices by different operators, expressed as the method-specific reproducibility of measurement results reported in External Quality Assessment (EQA) schemes, is an indicator for this characteristic.\r\n\r\nLegal frameworks in the EU, the USA and Australia were evaluated about their requirements for NPT/POCT. EQA reproducibility of seven SARS-CoV-2-NAAT systems, all but one designated as \"POCT\", was calculated from variabilities in Ct values obtained from the respective device types in three different EQA schemes for virus genome detection.\r\n\r\nA matrix for characterizing test systems based on their technical complexity and the required operator competence was derived from requirements of the European In Vitro Diagnostic Regulation (IVDR) 2017/746. Good EQA reproducibility of the measurement results of the test systems investigated implies that different users in different locations have no recognizable influence on their measurement results.\r\n\r\nThe fundamental suitability of test systems for NPT/POCT use according to IVDR can be easily verified using the evaluation matrix presented. EQA reproducibility is a specific characteristic indicating independence from operator activities of NPT/POCT assays. EQA reproducibility of other systems than those investigated here remains to be determined.", "doi": "10.1016/j.jcv.2023.105521", "pmid": "37302248", "labels": {"Category: Health": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10249340"}, {"db": "pii", "key": "S1386-6532(23)00144-0"}], "notes": [], "created": "2023-10-04T09:33:21.018Z", "modified": "2023-10-04T11:24:26.997Z"}, {"entity": "publication", "iuid": "fe5a3c1f5a5b4f54978442d6e30d165e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fe5a3c1f5a5b4f54978442d6e30d165e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fe5a3c1f5a5b4f54978442d6e30d165e"}}, "title": "Certified Registered Nurse Anesthetists' Experience of Relocation to COVID-19 Intensive Care-A Qualitative Interview Study.", "authors": [{"family": "Sundblad", "given": "Hanna", "initials": "H"}, {"family": "Hommel", "given": "Ami", "initials": "A"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "AANA J", "issn": "2162-5239", "issn-l": null, "volume": "91", "issue": "4", "pages": "273-278"}, "abstract": "In spring 2020, a global SARS-Cov-2 pandemic was declared. The number of patients in need of intensive care exceeded the number of available care places at intensive care units (ICUs) and certified registered nurse anesthetists (CRNAs) were relocated to ICUs to support the care during the pandemic. The aim of this study was to illuminate the experiences of the CRNAs regarding relocation to COVID-19 intensive care. An interview study based on qualitative content analysis was conducted. The participants were CRNAs who usually work in the operating unit, however, were relocated to work in the COVID-19 ICU at a university hospital in southern Sweden during the pandemic. Four themes emerge in the results: sense of pride, competence, work environment, and nursing. The results illuminate the CRNAs' experience of relocating from their usual working environment to caring for critically ill patients in a COVID-19 ICU. The CRNAs managed the relocation well, although sometimes it was difficult. The CRNAs showed great loyalty, dedication, competence, and flexibility in their professional capacity. The time they worked in COVID-19 intensive care was a challenging period, but it gave them a well-deserved sense of pride and competence.", "doi": null, "pmid": "37527166", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:01:43.210Z", "modified": "2023-10-05T08:33:29.679Z"}, {"entity": "publication", "iuid": "a6f1f97a78a040648dfc986fcc4278c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6f1f97a78a040648dfc986fcc4278c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6f1f97a78a040648dfc986fcc4278c0"}}, "title": "The impact of hybrid immunity on immune responses after SARS-CoV-2 vaccination in persons with multiple sclerosis treated with disease-modifying therapies.", "authors": [{"family": "Rabenstein", "given": "Monika", "initials": "M"}, {"family": "Thomas", "given": "Olivia G", "initials": "OG"}, {"family": "Carlin", "given": "Giorgia", "initials": "G"}, {"family": "Khademi", "given": "Mohsen", "initials": "M"}, {"family": "H\u00f6gelin", "given": "Klara Asplund", "initials": "KA", "orcid": "0000-0002-3696-355X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e30a564a8ac14f97af8d46d222dff3ab.json"}}, {"family": "Malmestr\u00f6m", "given": "Clas", "initials": "C"}, {"family": "Axelsson", "given": "Markus", "initials": "M"}, {"family": "Brandt", "given": "Anne Frandsen", "initials": "AF"}, {"family": "Gafvelin", "given": "Guro", "initials": "G"}, {"family": "Gr\u00f6nlund", "given": "Hans", "initials": "H"}, {"family": "Kockum", "given": "Ingrid", "initials": "I"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Lycke", "given": "Jan", "initials": "J"}, {"family": "Olsson", "given": "Tomas", "initials": "T"}, {"family": "Hessa", "given": "Tara", "initials": "T"}], "type": "journal article", "published": "2023-07-31", "journal": {"title": "Eur J Neurol", "issn": "1468-1331", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Hybrid immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develops from a combination of natural infection and vaccine-generated immunity. Multiple sclerosis (MS) disease-modifying therapies (DMTs) have the potential to impact humoral and cellular immunity induced by SARS-CoV-2 vaccination and infection. The aims were to compare antibody and T-cell responses after SARS-CoV-2 mRNA vaccination in persons with MS (pwMS) treated with different DMTs and to assess differences between na\u00efvely vaccinated pwMS and pwMS with hybrid immunity vaccinated following a previous SARS-CoV-2 infection.\r\n\r\nAntibody and T-cell responses were determined in pwMS at baseline and 4 and 12 weeks after the second dose of SARS-CoV-2 vaccination in 143 pwMS with or without previous SARS-CoV-2 infection and 40 healthy controls (HCs). The MS cohort comprised natalizumab (n = 22), dimethylfumarate (n = 23), fingolimod (n = 38), cladribine (n = 30), alemtuzumab (n = 17) and teriflunomide (n = 13) treated pwMS. Immunoglobulin G antibody responses to SARS-CoV-2 antigens were measured using a multiplex bead assay and FluoroSpot was used to assess T-cell responses (interferon \u03b3 and interleukin 13).\r\n\r\nHumoral and T-cell responses to vaccination were comparable between na\u00efvely vaccinated HCs and pwMS treated with natalizumab, dimethylfumarate, cladribine, alemtuzumab and teriflunomide, but were suppressed in fingolimod-treated pwMS. Both fingolimod-treated pwMS and HCs vaccinated following a previous SARS-CoV-2 infection had higher antibody levels 4 weeks after vaccination compared to na\u00efvely vaccinated individuals. Antibody and interferon \u03b3 levels 12 weeks after vaccination were positively correlated with time from last treatment course of cladribine.\r\n\r\nThese findings are of relevance for infection risk mitigation and for vaccination strategies amongst pwMS undergoing DMT.", "doi": "10.1111/ene.16015", "pmid": "37522464", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:09:27.597Z", "modified": "2023-10-04T12:53:25.039Z"}, {"entity": "publication", "iuid": "119a8efc353f427ea1abf28986ba5525", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/119a8efc353f427ea1abf28986ba5525.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/119a8efc353f427ea1abf28986ba5525"}}, "title": "Supportive public health leadership for COVID-19 response in Jordan.", "authors": [{"family": "Bellizzi", "given": "Saverio", "initials": "S"}, {"family": "Asghar", "given": "Humayun", "initials": "H"}, {"family": "Bile", "given": "Khalif", "initials": "K"}], "type": "case reports", "published": "2023-07-31", "journal": {"title": "East Mediterr Health J", "issn": "1687-1634", "issn-l": null, "volume": "29", "issue": "7", "pages": "575-579"}, "abstract": "The WHO Regional Office for the Eastern Mediterranean and the United Nations System Staff College (UNSSC) implemented a leadership programme on epidemic and pandemic preparedness and response, specific to the COVID-19 pandemic, during the second half of 2021.\r\n\r\nTo highlight the leadership role played by the WHO Jordan Country Office during the COVID-19 pandemic in collaboration with UNSSC.\r\n\r\nThe WHO Jordan country office successfully leveraged the expertise of UNSSC to implement a leadership training to prepare key stakeholders in Jordan for the response to COVID-19 and similar pandemics or outbreaks. The training curriculum included several modules such as leadership in times of crisis, strategic thinking and planning, emotional resilience, preparedness, adopting a system approach to response, and multisectoral partnership-building for pandemic response. The training helped strengthen the generation of evidence for policymaking and promotion of equitable access to health during the COVID-19 pandemic.\r\n\r\nLeadership capacity strengthening of national counterparts by WHO and partners can help advance efforts at national level to increase the use of evidence for policymaking and response to pandemics and disease outbreaks.", "doi": "10.26719/emhj.23.035", "pmid": "37553746", "labels": {"Category: Public Health": null, "Type: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:08:49.548Z", "modified": "2023-10-06T04:38:03.240Z"}, {"entity": "publication", "iuid": "3610fea119cc4cf5a9d702276b381831", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3610fea119cc4cf5a9d702276b381831.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3610fea119cc4cf5a9d702276b381831"}}, "title": "COVID-19 vaccine safety during pregnancy and breastfeeding in women with autoimmune diseases: results from the COVAD study.", "authors": [{"family": "Andreoli", "given": "Laura", "initials": "L"}, {"family": "Lini", "given": "Daniele", "initials": "D"}, {"family": "Schreiber", "given": "Karen", "initials": "K"}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Naveen", "given": "R", "initials": "R", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Jagtap", "given": "Kshitij", "initials": "K", "orcid": "0000-0003-2729-737X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822b9da98e5d4eb2975ff97fe484933f.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Saha", "given": "Sreoshy", "initials": "S", "orcid": "0000-0001-6745-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00238845dd4833ae51ffb75e2fe144.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Edgar Gracia-Ramos", "given": "Abraham", "initials": "A", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}, {"family": "Patel", "given": "Aarat", "initials": "A"}, {"family": "Pauling", "given": "John D", "initials": "JD", "orcid": "0000-0002-2793-2364", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e37709273d404d17a88c7c850777b99f.json"}}, {"family": "Wincup", "given": "Chris", "initials": "C", "orcid": "0000-0002-8742-8311", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a674f02e7f7f45f58167eb24f81502f3.json"}}, {"family": "Barman", "given": "Bhupen", "initials": "B"}, {"family": "Zamora Tehozol", "given": "Erick Adrian", "initials": "EA", "orcid": "0000-0002-7888-3961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a55c695ac4f4003993a2f511cca7739.json"}}, {"family": "Serrano", "given": "Jorge Rojas", "initials": "JR", "orcid": "0000-0001-6980-7898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/225fd8b396ac40f4a77f1ec229c086b6.json"}}, {"family": "Garc\u00eda-De La Torre", "given": "Ignacio", "initials": "I", "orcid": "0000-0002-9261-678X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/086b85d66fb84b50bd51bbe5a979dfe3.json"}}, {"family": "Colunga-Pedraza", "given": "Iris J", "initials": "IJ", "orcid": "0000-0002-2786-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50e46ef2c7f44b39a1d28fea6a8e621d.json"}}, {"family": "Merayo-Chalico", "given": "Javier", "initials": "J", "orcid": "0000-0002-5870-0523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d74c0ab33cbe4df586e1a1add37d0e65.json"}}, {"family": "Chibuzo", "given": "Okwara Celestine", "initials": "OC"}, {"family": "Katchamart", "given": "Wanruchada", "initials": "W", "orcid": "0000-0002-8952-5967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9439933b38fb49aca8fdbb5038ff603c.json"}}, {"family": "Akarawatcharangura Goo", "given": "Phonpen", "initials": "P"}, {"family": "Shumnalieva", "given": "Russka", "initials": "R", "orcid": "0000-0003-2321-6536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/933232cd7feb48ee81b5971f01f52e23.json"}}, {"family": "Chen", "given": "Yi-Ming", "initials": "Y"}, {"family": "Hoff", "given": "Leonardo Santos", "initials": "LS", "orcid": "0000-0002-2083-4796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1df7af8caf024ca39c57278fdf18c766.json"}}, {"family": "El Kibbi", "given": "Lina", "initials": "L", "orcid": "0000-0003-1710-9996", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11bb4fc524264c6897dec9642a0ef7cd.json"}}, {"family": "Halabi", "given": "Hussein", "initials": "H", "orcid": "0000-0002-5174-8292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb337090a5ab4461a07e8620bee1b4b9.json"}}, {"family": "Vaidya", "given": "Binit", "initials": "B", "orcid": "0000-0002-4840-8924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b2296d53fe14fc7a8415f26e03e1944.json"}}, {"family": "Sazliyana Shaharir", "given": "Syahrul", "initials": "S", "orcid": "0000-0002-9068-8114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1e6310979d44d58b548c61c733412af.json"}}, {"family": "Hasan", "given": "A T M Tanveer", "initials": "ATMT", "orcid": "0000-0002-5332-3319", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ffdb3329292438fac4005923ee79012.json"}}, {"family": "Dey", "given": "Dzifa", "initials": "D"}, {"family": "Guti\u00e9rrez", "given": "Carlos Enrique Toro", "initials": "CET", "orcid": "0000-0002-6084-7049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/980e455c5d114caaaefb6e0b55eaa3b3.json"}}, {"family": "Caballero-Uribe", "given": "Carlo V", "initials": "CV"}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "group", "given": "COVAD study", "initials": "Cs"}, {"family": ",", "given": "", "initials": ""}, {"family": "Chinoy", "given": "Gabriela Arredondo Hector", "initials": "GAH", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}], "type": "journal article", "published": "2023-07-28", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "We investigated COVID-19 vaccine safety in pregnant and breastfeeding women with autoimmune diseases (AID) in the COVID-19 Vaccination in Autoimmune Diseases (COVAD) study.\r\n\r\nDelayed-onset (>7 days) vaccine-related adverse events (AE), disease flares (DF), and AID-related treatment modifications were analyzed upon diagnosis of AID versus healthy controls (HC) and the pregnancy/breastfeeding status at the time of at least one dose of vaccine.\r\n\r\nAmong the 9201 participants to the self-administered online survey, 6787 (73.8%) were women. Forty pregnant and 52 breastfeeding patients with AID were identified, of whom the majority had received at least one dose of COVID-19 vaccine (100% and 96.2%, respectively). AE were reported significantly more frequently in pregnant than in non-pregnant patients (overall AE 45% vs 26%, p= 0.01; minor AE 40% vs 25.9%, p= 0.03; major AE 17.5% vs 4.6%, p< 0.01), but no difference was found in comparison with pregnant HC. No difference was observed between breastfeeding patients and HC with respect to AE. Post-vaccination DF were reported by 17.5% of pregnant and 20% of breastfeeding patients, and by 18.3% of age- and disease-matched non-pregnant and non-breastfeeding patients (n = 262). All pregnant/breastfeeding patients who experienced a DF were managed with glucocorticoids; 28.6% and 20% of them required initiation or change in immunosuppressants, respectively.\r\n\r\nThis study provides reassuring insights into the safety of COVID-19 vaccines administered to women with AID during the gestational and post-partum periods, helping overcome hesitant attitudes, as the benefits for the mother and the fetus by passive immunization appear to outweigh potential risks.", "doi": "10.1093/rheumatology/kead382", "pmid": "37505460", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "7233066"}], "notes": [], "created": "2023-10-04T12:10:03.914Z", "modified": "2023-10-04T13:08:59.955Z"}, {"entity": "publication", "iuid": "02865561b5ed4712a71ebd97c8baa32b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02865561b5ed4712a71ebd97c8baa32b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02865561b5ed4712a71ebd97c8baa32b"}}, "title": "Anxiety, concerns and COVID-19: Cross-country perspectives from families and individuals with neurodevelopmental conditions.", "authors": [{"family": "Sideropoulos", "given": "Vassilis", "initials": "V"}, {"family": "Van Herwegen", "given": "Jo", "initials": "J"}, {"family": "Meuleman", "given": "Ben", "initials": "B"}, {"family": "Alessandri", "given": "Michael", "initials": "M"}, {"family": "Alnemary", "given": "Faisal M", "initials": "FM"}, {"family": "Rad", "given": "Jamal Amani", "initials": "JA"}, {"family": "Lavenex", "given": "Pamela A Banta", "initials": "PAB"}, {"family": "Bolshakov", "given": "Nikita", "initials": "N"}, {"family": "B\u00f6lte", "given": "Sven", "initials": "S"}, {"family": "Buffle", "given": "Paulina", "initials": "P"}, {"family": "Cai", "given": "Ru Y", "initials": "RY"}, {"family": "Campos", "given": "Ruth", "initials": "R"}, {"family": "Chirita-Emandi", "given": "Adela", "initials": "A"}, {"family": "Costa", "given": "Andreia P", "initials": "AP"}, {"family": "Costanzo", "given": "Floriana", "initials": "F"}, {"family": "Des Portes", "given": "Vincent", "initials": "V"}, {"family": "Dukes", "given": "Daniel", "initials": "D"}, {"family": "Faivre", "given": "Laurence", "initials": "L"}, {"family": "Famelart", "given": "Nawelle", "initials": "N"}, {"family": "Fisher", "given": "Marisa H", "initials": "MH"}, {"family": "Gamaiunova", "given": "Liudmilla", "initials": "L"}, {"family": "Giannadou", "given": "Aikaterini", "initials": "A"}, {"family": "Gupta", "given": "Rashmi", "initials": "R"}, {"family": "Hardan", "given": "Antonio Y", "initials": "AY"}, {"family": "Houdayer-Robert", "given": "Fran\u00e7oise", "initials": "F"}, {"family": "Hrncirova", "given": "Lenka", "initials": "L"}, {"family": "Iaochite", "given": "Roberto Tadeu", "initials": "RT"}, {"family": "Jariabkova", "given": "Katarina", "initials": "K"}, {"family": "Klein-Tasman", "given": "Bonita P", "initials": "BP"}, {"family": "Lavenex", "given": "Pierre", "initials": "P"}, {"family": "Malik", "given": "Supriya", "initials": "S"}, {"family": "Mari", "given": "Francesca", "initials": "F"}, {"family": "Martinez-Castilla", "given": "Pastora", "initials": "P"}, {"family": "Menghini", "given": "Deny", "initials": "D"}, {"family": "Nuske", "given": "Heather J", "initials": "HJ"}, {"family": "Palikara", "given": "Olympia", "initials": "O"}, {"family": "Papon", "given": "Anouk", "initials": "A"}, {"family": "Pegg", "given": "Robin S", "initials": "RS"}, {"family": "Pouretemad", "given": "Hamidreza", "initials": "H"}, {"family": "Poustka", "given": "Luise", "initials": "L"}, {"family": "Prosetzky", "given": "Ingolf", "initials": "I"}, {"family": "Renieri", "given": "Alessandra", "initials": "A"}, {"family": "Rhodes", "given": "Sinead M", "initials": "SM"}, {"family": "Riby", "given": "Deborah M", "initials": "DM"}, {"family": "Rossi", "given": "Massimiliano", "initials": "M"}, {"family": "Sadeghi", "given": "Saeid", "initials": "S"}, {"family": "Su", "given": "Xueyen", "initials": "X"}, {"family": "Tai", "given": "Claire", "initials": "C"}, {"family": "Tran", "given": "Michel", "initials": "M"}, {"family": "Tynan", "given": "Fionnuala", "initials": "F"}, {"family": "Uljarevi\u0107", "given": "Mirko", "initials": "M"}, {"family": "Van Hecke", "given": "Amy V", "initials": "AV"}, {"family": "Veiga", "given": "Guida", "initials": "G"}, {"family": "Verloes", "given": "Alain", "initials": "A"}, {"family": "Vicari", "given": "Stefano", "initials": "S"}, {"family": "Werneck-Rohrer", "given": "Sonja G", "initials": "SG"}, {"family": "Zander", "given": "Eric", "initials": "E"}, {"family": "Samson", "given": "Andrea C", "initials": "AC"}], "type": "journal article", "published": "2023-07-28", "journal": {"title": "J Glob Health", "issn": "2047-2986", "issn-l": "2047-2978", "volume": "13", "issue": null, "pages": "04081"}, "abstract": "The COVID-19 pandemic had a major impact on the mental health and well-being of children with neurodevelopmental conditions (NDCs) and of their families worldwide. However, there is insufficient evidence to understand how different factors (e.g., individual, family, country, children) have impacted on anxiety levels of families and their children with NDCs developed over time.\r\n\r\nWe used data from a global survey assessing the experience of 8043 families and their children with NDCs (mean of age (m) = 13.18 years, 37% female) and their typically developing siblings (m = 12.9 years, 45% female) in combination with data from the European Centre for Disease Prevention and Control, the University of Oxford, and the Central Intelligence Agency (CIA) World Factbook, to create a multilevel data set. Using stepwise multilevel modelling, we generated child-, family- and country-related factors that may have contributed to the anxiety levels of children with NDCs, their siblings if they had any, and their parents. All data were reported by parents.\r\n\r\nOur results suggest that parental anxiety was best explained by family-related factors such as concerns about COVID-19 and illness. Children's anxiety was best explained by child-related factors such as children's concerns about loss of routine, family conflict, and safety in general, as well as concerns about COVID-19. In addition, anxiety levels were linked to the presence of pre-existing anxiety conditions for both children with NDCs and their parents.\r\n\r\nThe present study shows that across the globe there was a raise in anxiety levels for both parents and their children with NDCs because of COVID-19 and that country-level factors had little or no impact on explaining differences in this increase, once family and child factors were considered. Our findings also highlight that certain groups of children with NDCs were at higher risk for anxiety than others and had specific concerns. Together, these results show that anxiety of families and their children with NDCs during the COVID-19 pandemic were predicted by very specific concerns and worries which inform the development of future toolkits and policy. Future studies should investigate how country factors can play a protective role during future crises.", "doi": "10.7189/jogh.13.04081", "pmid": "37497751", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10373111"}], "notes": [], "created": "2023-10-04T12:10:01.287Z", "modified": "2023-10-04T13:08:11.013Z"}, {"entity": "publication", "iuid": "959d789ffbd645a49354b747833a4cba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/959d789ffbd645a49354b747833a4cba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/959d789ffbd645a49354b747833a4cba"}}, "title": "The Impact of the COVID-19 Pandemic on Cutaneous Drug Eruptions in a Swedish Health Region without Lockdown.", "authors": [{"family": "Pissa", "given": "Maria", "initials": "M"}, {"family": "Jerkovic Gulin", "given": "Sandra", "initials": "S"}], "type": "journal article", "published": "2023-07-27", "journal": {"title": "Microorganisms", "issn": "2076-2607", "issn-l": "2076-2607", "volume": "11", "issue": "8", "pages": null}, "abstract": "The incidence of severe cutaneous drug eruptions during the COVID-19 period in Sweden has not been studied previously. Our aim was to compare the incidence of these skin reactions in a Swedish health region during the COVID-19 pandemic period with that of the year after: we conducted a retrospective, observational cohort study using data from a national registry of patients diagnosed with cutaneous drug eruptions during the pandemic in Sweden. We included the number of patients diagnosed with severe cutaneous drug eruptions at the Department of Dermatology in the Jonkoping health region during the COVID-19 pandemic (1 April 2020 to 31 March 2021) and the reference period (1 April 2021 to 31 March 2022). We examined the monthly occurrences of cutaneous drug eruptions in three dermatology clinics within the Jonkoping health region. The frequency of these eruptions was determined for two distinct time periods: during the pandemic and post-pandemic. The study included 102 patients with cutaneous drug eruptions: 29 patients were diagnosed during the COVID-19 pandemic period and 73 were diagnosed during the reference period. The difference in the number of cutaneous drug eruptions cases (p-value = 0.0001, 95% CI 1.4995-3.5500, OR 2.3072) during the pandemic period compared to the post-pandemic period was significant. To our knowledge, the impact of the pandemic on cutaneous drug eruptions has not been investigated in EU countries. The increasing and differentiation of the number of diagnosed cutaneous drug eruptions cases after the pandemic could be explained by the removal of COVID-19 restrictions and the more frequent health-seeking behavior during the post-pandemic period.", "doi": "10.3390/microorganisms11081913", "pmid": "37630473", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10459394"}, {"db": "pii", "key": "microorganisms11081913"}], "notes": [], "created": "2023-10-05T08:08:42.023Z", "modified": "2023-10-06T04:31:38.188Z"}, {"entity": "publication", "iuid": "58384bfd215648a29216bdea3bb43ada", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/58384bfd215648a29216bdea3bb43ada.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/58384bfd215648a29216bdea3bb43ada"}}, "title": "Immune response to SARS-CoV-2 mRNA vaccination in multiple sclerosis patients after rituximab treatment interruption.", "authors": [{"family": "Gr\u00f6ning", "given": "Remigius", "initials": "R"}, {"family": "Dernstedt", "given": "Andy", "initials": "A"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Sundstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}], "type": "journal article", "published": "2023-07-27", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "1219560"}, "abstract": "Peripheral B cell depletion via anti-CD20 treatment is a highly effective disease-modifying treatment for reducing new relapses in multiple sclerosis (MS) patients. A drawback of rituximab (RTX) and other anti-CD20 antibodies is a poor immune response to vaccination. While this can be mitigated by treatment interruption of at least six months prior to vaccination, the timing to resume treatment while maintaining subsequent vaccine responses remains undetermined. Here, we characterized SARS-CoV-2 S-directed antibody and B cell responses throughout three BNT162b2 mRNA vaccine doses in RTX-treated MS patients, with the first two doses given during treatment interruption. We examined B-cell mediated immune responses in blood samples from patients with RTX-treated MS throughout three BNT162b2 vaccine doses, compared to an age- and sex-matched healthy control group. The first vaccine dose was given 1.3 years (median) after the last RTX infusion, the second dose one month after the first, and the third dose four weeks after treatment re-initiation. We analyzed SARS-CoV-2 S-directed antibody levels using enzyme-linked immunosorbent assay (ELISA), and the neutralization capacity of patient serum against SARS-CoV-2 S-pseudotyped lentivirus using luciferase reporter assay. In addition, we assessed switched memory (CD19+CD20+CD27+IgD-), unswitched memory (CD19+CD20+CD27+IgD+), na\u00efve (CD19+CD20+CD27-IgD+), and double negative (DN, CD19+CD20+CD27-IgD-) B cell frequencies, as well as their SARS-CoV-2 S-specific (CoV+) and Decay Accelerating Factor-negative (DAF-) subpopulations, using flow cytometry. After two vaccine doses, S-binding antibody levels and neutralization capacity in SARS-CoV-2-na\u00efve MS patients were comparable to vaccinated healthy controls, albeit with greater variation. Higher antibody response levels and CoV+-DN B cell frequencies after the second vaccine dose were predictive of a boost effect after the third dose, even after re-initiation of rituximab treatment. MS patients also exhibited lower frequencies of DAF- memory B cells, a suggested proxy for germinal centre activity, than control individuals. S-binding antibody levels in RTX-treated MS patients after two vaccine doses could help determine which individuals would need to move up their next vaccine booster dose or postpone their next RTX infusion. Our findings also offer first indications on the potential importance of antigenic stimulation of DN B cells and long-term impairment of germinal centre activity in rituximab-treated MS patients.", "doi": "10.3389/fimmu.2023.1219560", "pmid": "37575257", "labels": {"Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10413123"}], "notes": [], "created": "2023-10-05T08:26:16.770Z", "modified": "2023-10-06T04:53:07.553Z"}, {"entity": "publication", "iuid": "a3ff29086df3421ca10205e0fd0dc8c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3ff29086df3421ca10205e0fd0dc8c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3ff29086df3421ca10205e0fd0dc8c9"}}, "title": "Policies on children and schools during the SARS-CoV-2 pandemic in Western Europe.", "authors": [{"family": "Soriano-Arandes", "given": "Antoni", "initials": "A"}, {"family": "Brett", "given": "Ana", "initials": "A"}, {"family": "Buonsenso", "given": "Danilo", "initials": "D"}, {"family": "Emilsson", "given": "Louise", "initials": "L"}, {"family": "de la Fuente Garcia", "given": "Isabel", "initials": "I"}, {"family": "Gkentzi", "given": "Despoina", "initials": "D"}, {"family": "Helve", "given": "Otto", "initials": "O"}, {"family": "Kepp", "given": "Kasper P", "initials": "KP"}, {"family": "Mossberg", "given": "Maria", "initials": "M"}, {"family": "Muka", "given": "Taulant", "initials": "T"}, {"family": "Munro", "given": "Alasdair", "initials": "A"}, {"family": "Papan", "given": "Cihan", "initials": "C"}, {"family": "Perramon-Malavez", "given": "Aida", "initials": "A"}, {"family": "Schaltz-Buchholzer", "given": "Frederik", "initials": "F"}, {"family": "Smeesters", "given": "Pierre R", "initials": "PR"}, {"family": "Zimmermann", "given": "Petra", "initials": "P"}], "type": "journal article", "published": "2023-07-25", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "1175444"}, "abstract": "During the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), mitigation policies for children have been a topic of considerable uncertainty and debate. Although some children have co-morbidities which increase their risk for severe coronavirus disease (COVID-19), and complications such as multisystem inflammatory syndrome and long COVID, most children only get mild COVID-19. On the other hand, consistent evidence shows that mass mitigation measures had enormous adverse impacts on children. A central question can thus be posed: What amount of mitigation should children bear, in response to a disease that is disproportionally affecting older people? In this review, we analyze the distinct child versus adult epidemiology, policies, mitigation trade-offs and outcomes in children in Western Europe. The highly heterogenous European policies applied to children compared to adults did not lead to significant measurable differences in outcomes. Remarkably, the relative epidemiological importance of transmission from school-age children to other age groups remains uncertain, with current evidence suggesting that schools often follow, rather than lead, community transmission. Important learning points for future pandemics are summarized.", "doi": "10.3389/fpubh.2023.1175444", "pmid": "37564427", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10411527"}], "notes": [], "created": "2023-10-05T08:02:38.935Z", "modified": "2023-10-05T08:48:36.368Z"}, {"entity": "publication", "iuid": "5197070c0aaa4a3fa1e29395a456374d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5197070c0aaa4a3fa1e29395a456374d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5197070c0aaa4a3fa1e29395a456374d"}}, "title": "Comparative effectiveness of bivalent BA.4-5 and BA.1 mRNA booster vaccines among adults aged \u226550 years in Nordic countries: nationwide cohort study.", "authors": [{"family": "Andersson", "given": "Niklas Worm", "initials": "NW", "orcid": "0000-0001-7622-6303", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e4000bddcc34ce5987e9ccccc76a858.json"}}, {"family": "Thiesson", "given": "Emilia Myrup", "initials": "EM"}, {"family": "Baum", "given": "Ulrike", "initials": "U"}, {"family": "Pihlstr\u00f6m", "given": "Nicklas", "initials": "N"}, {"family": "Starrfelt", "given": "Jostein", "initials": "J"}, {"family": "Faksov\u00e1", "given": "Krist\u00fdna", "initials": "K"}, {"family": "Poukka", "given": "Eero", "initials": "E"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}, {"family": "Ljung", "given": "Rickard", "initials": "R"}, {"family": "Hviid", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2023-07-25", "journal": {"title": "BMJ", "issn": "1756-1833", "issn-l": null, "volume": "382", "issue": null, "pages": "e075286"}, "abstract": "To estimate the effectiveness of the bivalent mRNA booster vaccines containing the original SARS-CoV-2 and omicron BA.4-5 or BA.1 subvariants as the fourth dose against severe covid-19.\r\n\r\nNationwide cohort analyses, using target trial emulation.\r\n\r\nDenmark, Finland, Norway, and Sweden, from 1 July 2022 to 10 April 2023.\r\n\r\nPeople aged \u226550 years who had received at least three doses of covid-19 vaccine (that is, a primary course and a first booster).\r\n\r\nThe Kaplan-Meier estimator was used to compare the risk of hospital admission and death related to covid-19 in people who received a bivalent Comirnaty (Pfizer-BioNTech) or Spikevax (Moderna) BA.4-5 or BA.1 mRNA booster vaccine as a fourth dose (second booster) with three dose (first booster) vaccinated people and between four dose vaccinated people.\r\n\r\nA total of 1 634 199 people receiving bivalent BA.4-5 fourth dose booster and 1 042 124 receiving bivalent BA.1 fourth dose booster across the four Nordic countries were included. Receipt of a bivalent BA.4-5 booster as a fourth dose was associated with a comparative vaccine effectiveness against admission to hospital with covid-19 of 67.8% (95% confidence interval 63.1% to 72.5%) and a risk difference of -91.9 (95% confidence interval -152.4 to -31.4) per 100 000 people at three months of follow-up compared with having received three doses of vaccine (289 v 893 events). The corresponding comparative vaccine effectiveness and risk difference for bivalent BA.1 boosters (332 v 977 events) were 65.8% (59.1% to 72.4%) and -112.9 (-179.6 to -46.2) per 100 000, respectively. Comparative vaccine effectiveness and risk difference against covid-19 related death were 69.8% (52.8% to 86.8%) and -34.1 (-40.1 to -28.2) per 100 000 for bivalent BA.4-5 booster (93 v 325 events) and 70.0% (50.3% to 89.7%) and -38.7 (-65.4 to -12.0) per 100 000 for BA.1 booster (86 v 286) as a fourth dose. Comparing bivalent BA.4-5 and BA.1 boosters as a fourth dose directly resulted in a three month comparative vaccine effectiveness and corresponding risk difference of -14.9% (-62.3% to 32.4%) and 10.0 (-14.4 to 34.4) per 100 000 people for admission to hospital with covid-19 (802 v 932 unweighted events) and -40.7% (-123.4% to 42.1%) and 8.1 (-3.3 to 19.4) per 100 000 for covid-19 related death (229 v 243 unweighted events). The comparative vaccine effectiveness did not differ across sex and age (<\/\u226570 years) and seemed to be sustained up to six months from the day of vaccination with modest waning.\r\n\r\nVaccination with bivalent BA.4-5 or BA.1 mRNA booster vaccines as a fourth dose was associated with reduced rates of covid-19 related hospital admission and death among adults aged \u226550 years. The protection afforded by the bivalent BA.4-5 and BA.1 boosters did not differ significantly when directly compared, and any potential difference would most likely be very small in absolute numbers.", "doi": "10.1136/bmj-2022-075286", "pmid": "37491022", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10364194"}], "notes": [], "created": "2023-10-04T12:08:15.579Z", "modified": "2023-10-04T12:31:14.841Z"}, {"entity": "publication", "iuid": "0b66e9f896bc494991a0bbf34ef5df9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b66e9f896bc494991a0bbf34ef5df9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b66e9f896bc494991a0bbf34ef5df9c"}}, "title": "Comparative effectiveness of heterologous third dose vaccine schedules against severe covid-19 during omicron predominance in Nordic countries: population based cohort analyses.", "authors": [{"family": "Andersson", "given": "Niklas Worm", "initials": "NW", "orcid": "0000-0001-7622-6303", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e4000bddcc34ce5987e9ccccc76a858.json"}}, {"family": "Thiesson", "given": "Emilia Myrup", "initials": "EM"}, {"family": "Baum", "given": "Ulrike", "initials": "U"}, {"family": "Pihlstr\u00f6m", "given": "Nicklas", "initials": "N"}, {"family": "Starrfelt", "given": "Jostein", "initials": "J"}, {"family": "Faksov\u00e1", "given": "Krist\u00fdna", "initials": "K"}, {"family": "Poukka", "given": "Eero", "initials": "E"}, {"family": "Lund", "given": "Lars Christian", "initials": "LC"}, {"family": "Hansen", "given": "Christian Holm", "initials": "CH"}, {"family": "Aakj\u00e6r", "given": "Mia", "initials": "M"}, {"family": "Kj\u00e6r", "given": "Jesper", "initials": "J"}, {"family": "Cohet", "given": "Catherine", "initials": "C"}, {"family": "Goossens", "given": "Mathijs", "initials": "M"}, {"family": "Andersen", "given": "Morten", "initials": "M"}, {"family": "Hallas", "given": "Jesper", "initials": "J"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}, {"family": "Ljung", "given": "Rickard", "initials": "R"}, {"family": "Hviid", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2023-07-24", "journal": {"title": "BMJ", "issn": "1756-1833", "issn-l": null, "volume": "382", "issue": null, "pages": "e074325"}, "abstract": "To investigate the comparative vaccine effectiveness of heterologous booster schedules (ie, three vaccine doses) compared with primary schedules (two vaccine doses) and with homologous mRNA vaccine booster schedules (three vaccine doses) during a period of omicron predominance.\r\n\r\nPopulation based cohort analyses.\r\n\r\nDenmark, Finland, Norway, and Sweden, 27 December 2020 to 31 December 2022.\r\n\r\nAll adults aged \u226518 years who had received at least a primary vaccination schedule of AZD1222 (Oxford-AstraZeneca) or monovalent SARS-CoV-2 wild type (ancestral) strain based mRNA vaccines BNT162b2 (Pfizer-BioNTech) or mRNA-1273 (Moderna), in any combination.\r\n\r\nThe main outcome measure was country combined risks of covid-19 related hospital admission and death with covid-19 and additional outcomes of covid-19 related admission to an intensive care unit and SARS-CoV-2 infection. During a period of omicron predominance, these outcomes were compared in those who received a heterologous booster versus primary schedule (matched analyses) and versus those who received a homologous mRNA vaccine booster (weighted analyses). Follow-up was for 75 days from day 14 after the booster dose; comparative vaccine effectiveness was calculated as 1-risk ratio.\r\n\r\nAcross the four Nordic countries, 1 086 418 participants had received a heterologous booster schedule of AZD1222+BNT162b2 or mRNA-1273 and 2 505 093 had received a heterologous booster schedule of BNT162b2+mRNA-1273. Compared with the primary schedule only (two doses), the vaccine effectiveness of heterologous booster schedules comprising AZD1222+BNT162b2 or mRNA-1273 and BNT162b2+mRNA-1273 was 82.7% (95% confidence interval 77.1% to 88.2%) and 81.5% (78.9% to 84.2%) for covid-19 related hospital admission and 95.9% (91.6% to 100.0%) and 87.5% (82.5% to 92.6%) for death with covid-19, respectively. Homologous mRNA booster schedules were similarly associated with increased protection against covid-19 related hospital admission (\u226576.5%) and death with covid-19 (\u226584.1%) compared with previous primary course vaccination only. When a heterologous booster schedule was compared with the homologous booster schedule, vaccine effectiveness was 27.2% (3.7% to 50.6%) for AZD1222+BNT162b2 or mRNA-1273 and 23.3% (15.8% to 30.8%) for BNT162b2+mRNA-1273 schedules against covid-19 related hospital admission and 21.7% (-8.3% to 51.7%) and 18.4% (-15.7% to 52.5%) against death with covid-19, respectively.\r\n\r\nHeterologous booster schedules are associated with increased protection against severe, omicron related covid-19 outcomes compared with primary course schedules and homologous booster schedules.", "doi": "10.1136/bmj-2022-074325", "pmid": "37487623", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10360027"}], "notes": [], "created": "2023-10-04T12:07:43.563Z", "modified": "2023-10-04T12:23:39.030Z"}, {"entity": "publication", "iuid": "979c9b04b372456284e6e053caac01f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/979c9b04b372456284e6e053caac01f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/979c9b04b372456284e6e053caac01f4"}}, "title": "COVID-19-Induced Acute Respiratory Distress Syndrome Treated with Hyperbaric Oxygen: Interim Safety Report from a Randomized Clinical Trial (COVID-19-HBO).", "authors": [{"family": "Kjellberg", "given": "Anders", "initials": "A", "orcid": "0000-0002-4819-1024", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81941232265d46679c08c40c068e91c4.json"}}, {"family": "Douglas", "given": "Johan", "initials": "J"}, {"family": "Hassler", "given": "Adrian", "initials": "A"}, {"family": "Al-Ezerjawi", "given": "Sarah", "initials": "S"}, {"family": "Bostr\u00f6m", "given": "Emil", "initials": "E"}, {"family": "Abdel-Halim", "given": "Lina", "initials": "L"}, {"family": "Liwenborg", "given": "Lovisa", "initials": "L"}, {"family": "Hetting", "given": "Eric", "initials": "E"}, {"family": "Jonasdottir Nj\u00e5stad", "given": "Anna Dora", "initials": "AD"}, {"family": "Kowalski", "given": "Jan", "initials": "J"}, {"family": "Catrina", "given": "Sergiu-Bogdan", "initials": "S"}, {"family": "Rodriguez-Wallberg", "given": "Kenny A", "initials": "KA", "orcid": "0000-0003-4378-6181", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d45aa8a66f64858b4f9be050046e8a2.json"}}, {"family": "Lindholm", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2023-07-24", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "12", "issue": "14", "pages": null}, "abstract": "A few prospective trials and case series have suggested that hyperbaric oxygen therapy (HBOT) may be efficacious for the treatment of severe COVID-19, but safety is a concern for critically ill patients. We present an interim analysis of the safety of HBOT via a randomized controlled trial (COVID-19-HBO).\r\n\r\nA randomized controlled, open-label, clinical trial was conducted in compliance with good clinical practice to explore the safety and efficacy of HBOT for severe COVID-19 in critically ill patients with moderate acute respiratory distress syndrome (ARDS). Between 3 June 2020, and 17 May 2021, 31 patients with severe COVID-19 and moderate-to-severe ARDS, a ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FiO2) < 26.7 kPa (200 mmHg), and at least two defined risk factors for intensive care unit (ICU) admission and/or mortality were enrolled in the trial and randomized 1:1 to best practice, or HBOT in addition to best practice. The subjects allocated to HBOT received a maximum of five treatments at 2.4 atmospheres absolute (ATA) for 80 min over seven days. The subjects were followed up for 30 days. The safety endpoints were analyzed.\r\n\r\nAdverse events (AEs) were common. Hypoxia was the most common adverse event reported. There was no statistically significant difference between the groups. Numerically, serious adverse events (SAEs) and barotrauma were more frequent in the control group, and the differences between groups were in favor of the HBOT in PaO2/FiO2 (PFI) and the national early warning score (NEWS); statistically, however, the differences were not significant at day 7, and no difference was observed for the total oxygen burden and cumulative pulmonary oxygen toxicity dose (CPTD).\r\n\r\nHBOT appears to be safe as an intervention for critically ill patients with moderate-to-severe ARDS induced by COVID-19.\r\n\r\nNCT04327505 (31 March 2020) and EudraCT 2020-001349-37 (24 April 2020).", "doi": "10.3390/jcm12144850", "pmid": "37510965", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10381696"}, {"db": "pii", "key": "jcm12144850"}, {"db": "ClinicalTrials.gov", "key": "NCT04327505"}], "notes": [], "created": "2023-10-04T12:09:00.800Z", "modified": "2023-10-04T12:46:57.143Z"}, {"entity": "publication", "iuid": "3a6da6658c9b475c8daae7db7eee70c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a6da6658c9b475c8daae7db7eee70c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a6da6658c9b475c8daae7db7eee70c9"}}, "title": "The European experience with testing and surveillance during the first phase of the COVID-19 pandemic.", "authors": [{"family": "Stoto", "given": "Michael A", "initials": "MA", "orcid": "0000-0001-8293-471X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0312d97d6e2d4101b691bae6dbec98cb.json"}}, {"family": "Reno", "given": "Chiara", "initials": "C"}, {"family": "Tsolova", "given": "Svetla", "initials": "S"}, {"family": "Fantini", "given": "Maria Pia", "initials": "MP"}], "type": "journal article", "published": "2023-07-21", "journal": {"title": "Global Health", "issn": "1744-8603", "issn-l": "1744-8603", "volume": "19", "issue": "1", "pages": "51"}, "abstract": "COVID-19 pandemic provides a unique opportunity to learn the challenges encountered by public health emergency preparedness systems, both in terms of problems encountered and adaptations during and after the first wave, as well as successful responses to them.\r\n\r\nThis work draws on published literature, interviews with countries and institutional documents as part of a European Centre for Disease Prevention and Control project that aims to identify the implications for preparedness measurement derived from COVID-19 pandemic experience in order to advance future preparedness efforts in European Union member states. The analysis focused on testing and surveillance themes and five countries were considered, namely Italy, Germany, Finland, Spain and Croatia. Our analysis shown that a country's ability to conduct testing at scale was critical, especially early in the pandemic, and the inability to scale up testing operations created critical issues for public health operations such as contact tracing. Countries were required to develop new strategies, approaches, and policies under pressure and to review and revise them as the pandemic evolved, also considering that public health systems operate at the national, regional, and local level with respect to testing, contact tracing, and surveillance, and involve both government agencies as well as private organizations. Therefore, communication among multiple public and private entities at all levels and coordination of the testing and surveillance activities was critical.\r\n\r\nWith regard to testing and surveillance, three capabilities that were essential to the COVID-19 response in the first phase, and presumably in other public health emergencies: the ability to scale-up testing, contact tracing, surveillance efforts; flexibility to develop new strategies, approaches, and policies under pressure and to review and revise them as the pandemic evolved; and the ability to coordinate and communicate in complex public health systems that operate at the national, regional, and local level with respect and involve multiple government agencies as well as private organizations.", "doi": "10.1186/s12992-023-00950-9", "pmid": "37480125", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10362750"}, {"db": "pii", "key": "10.1186/s12992-023-00950-9"}], "notes": [], "created": "2023-10-04T12:09:51.345Z", "modified": "2023-10-04T13:03:47.580Z"}, {"entity": "publication", "iuid": "160193d3938347ad86b525744a2c8d29", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/160193d3938347ad86b525744a2c8d29.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/160193d3938347ad86b525744a2c8d29"}}, "title": "The Swedish COVID-19 approach: a scientific dialogue on mitigation policies.", "authors": [{"family": "Bj\u00f6rkman", "given": "Anders", "initials": "A"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Gullberg", "given": "Martin", "initials": "M"}, {"family": "Ludvigsson", "given": "Johnny", "initials": "J"}], "type": "journal article", "published": "2023-07-20", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "1206732"}, "abstract": "During the COVID-19 pandemic, Sweden was among the few countries that did not enforce strict lockdown measures but instead relied more on voluntary and sustainable mitigation recommendations. While supported by the majority of Swedes, this approach faced rapid and continuous criticism. Unfortunately, the respectful debate centered around scientific evidence often gave way to mudslinging. However, the available data on excess all-cause mortality rates indicate that Sweden experienced fewer deaths per population unit during the pandemic (2020-2022) than most high-income countries and was comparable to neighboring Nordic countries through the pandemic. An open, objective scientific dialogue is essential for learning and preparing for future outbreaks.", "doi": "10.3389/fpubh.2023.1206732", "pmid": "37546333", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10399217"}], "notes": [], "created": "2023-10-05T08:26:19.099Z", "modified": "2023-10-06T04:54:29.036Z"}, {"entity": "publication", "iuid": "17188b1b0b85452b82f931ef6a1c0098", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/17188b1b0b85452b82f931ef6a1c0098.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/17188b1b0b85452b82f931ef6a1c0098"}}, "title": "Making things work-In spite of a pandemic small scale enterprise managers' approach to business changes and health issues.", "authors": [{"family": "Landstad", "given": "Bodil J", "initials": "BJ", "orcid": "0000-0001-6558-3129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bdb9f75451d4f2b8c87a8f8a837a09d.json"}}, {"family": "Hedlund", "given": "Marianne", "initials": "M", "orcid": "0000-0002-1789-2477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d8e2939573845109d470f05b8314cee.json"}}, {"family": "Tjulin", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Nordenmark", "given": "Mikael", "initials": "M"}, {"family": "Vinberg", "given": "Stig", "initials": "S"}], "type": "journal article", "published": "2023-07-20", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "7", "pages": "e0288837"}, "abstract": "Covid-19 is one of the worst crises in modern working life with a direct negative impact on many enterprises and organizations. The aim of this study is to explore what managers in Small Scale Enterprises (SSEs) changed in their business during the Covid-19 pandemic, particularly addressing health issues.\r\n\r\nA longitudinal qualitative research methodology was used, interviewing 16 managers of SSEs in the Norwegian and Swedish manufacturing and service sector both before (round 1) and during the pandemic (round 2). In this approach, time is designed into the research process, making change a key focus for analysis.\r\n\r\nThe analysis resulted in two main themes, resilience and demanding occupational health and safety conditions, and five sub-themes. Results show how managers in SSEs changed their business during the Covid-19 pandemic and the impact of these changes. Although, the enterprises were heavily affected in the beginning of the pandemic, several managers found new solutions for their businesses to maintain and reach new customers. They applied a socially responsible management which addressed different health issues.\r\n\r\nCrises like the Covid-19 pandemic will have future impact on SSEs making it important to understand how managers in such enterprises address business and health issues. This knowledge may have practical implications for supporting managers in SSEs in how to perform a socially responsible management and maintain occupational health and safety measures. The managerial implications from this research are that they need to be flexible, reorientable and, at the same time, be loyal to the core business. This study shows the importance of doing longitudinal studies about business and health issues among mangers in SSEs.", "doi": "10.1371/journal.pone.0288837", "pmid": "37471417", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10358884"}, {"db": "pii", "key": "PONE-D-22-33735"}], "notes": [], "created": "2023-10-04T12:08:53.047Z", "modified": "2023-10-04T12:44:21.257Z"}, {"entity": "publication", "iuid": "8e0ff59d5c834afea39bb6f6652728e9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e0ff59d5c834afea39bb6f6652728e9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e0ff59d5c834afea39bb6f6652728e9"}}, "title": "Assessing the Knowledge, Attitudes, and Vaccination Practices Towards COVID-19 Vaccination Among Mainland Chinese Nursing Students and Interns: A Multicenter Cross-Sectional Study.", "authors": [{"family": "Qin", "given": "Zhuzhu", "initials": "Z"}, {"family": "Ye", "given": "Xinxin", "initials": "X"}, {"family": "Liu", "given": "Huanju", "initials": "H", "orcid": "0000-0002-3370-4296", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51415df31c7340ebb01f7537f1a86fce.json"}}, {"family": "Tao", "given": "Yining", "initials": "Y"}, {"family": "Zheng", "given": "Xutong", "initials": "X"}, {"family": "Zhong", "given": "Yanxia", "initials": "Y"}, {"family": "Chen", "given": "Danfeng", "initials": "D"}, {"family": "Ye", "given": "Wan", "initials": "W"}, {"family": "Zhan", "given": "Chenju", "initials": "C"}], "type": "journal article", "published": "2023-07-20", "journal": {"title": "Infect Drug Resist", "issn": "1178-6973", "issn-l": null, "volume": "16", "issue": null, "pages": "4717-4728"}, "abstract": "This study investigated factors influencing the knowledge, attitudes, practice profiles, and vaccination intentions among Chinese nursing students and nursing interns toward the coronavirus disease (COVID-19) vaccination.\r\n\r\nThe multicenter cross-sectional study was based on a self-reported questionnaire collecting information among nursing students and nursing interns from three major geographic regions of China, and the sample was selected by consecutive sampling. The questionnaire was developed by knowledge, attitudes, and practice (KAP) theory. Univariate and multivariate logistic regression were used for statistical analysis.\r\n\r\nA total of 3180 nursing students and interns (effective rate: 99.8%) from six Chinese provinces were polled. The vaccine hesitation rate was 9.65% (307/3180), 2230 participants (70.1%) had gotten at least one dose of the vaccine, and 643 participants (67.7%) had indicated a readiness to be vaccinated. The results showed that older age, higher academic background, perfect vaccine management, others' recommendations, influenza vaccination history, epidemic under control, knowledge of vaccines or intervals, and vaccine knowledge training were associated with higher vaccination rates. Conversely, vaccine hesitancy was caused by a perceived lack of physical need, uncertainty about vaccination requirements, and fear of vaccination.\r\n\r\nThis study provided population-based estimates of COVID-19 vaccine uptake intention among mainland Chinese nursing students and interns. Factors such as age, education, vaccine knowledge, and attitudes influence COVID-19 vaccine behaviour. Relevant authorities should understand the barriers to COVID-19 vaccination from knowledge, attitude and practice, which is significant for formulating effective response strategies in future global public health crises.", "doi": "10.2147/IDR.S415799", "pmid": "37496694", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10366673"}, {"db": "pii", "key": "415799"}], "notes": [], "created": "2023-10-04T12:09:53.826Z", "modified": "2023-10-04T13:04:36.946Z"}, {"entity": "publication", "iuid": "cf40e0b6004f481a992235ec3e50a034", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cf40e0b6004f481a992235ec3e50a034.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cf40e0b6004f481a992235ec3e50a034"}}, "title": "Understanding concerns after severe COVID-19: A self-imposed lockdown guarded by anxiety?", "authors": [{"family": "T\u00f6rnbom", "given": "Karin", "initials": "K", "orcid": "0000-0002-7593-2051", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64aa524f1b9d4b6a8e14312c6b298546.json"}}, {"family": "Larsson", "given": "Alexandra", "initials": "A"}, {"family": "Sunnerhagen", "given": "Katharina S", "initials": "KS"}, {"family": "Palstam", "given": "Annie", "initials": "A"}, {"family": "Persson", "given": "Hanna C", "initials": "HC"}], "type": "journal article", "published": "2023-07-19", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "7", "pages": "e0287981"}, "abstract": "Many people are struggling to get back to their lives after severe COVID-19. To facilitate their reintegration into everyday life, we need to understand how the process is experienced. We aimed to gain deeper knowledge about this process by interviewing persons one year after hospitalisation due to COVID-19.\r\n\r\nThe study is based on a qualitative design, with eleven in-depth interviews conducted one year after discharge for COVID-19. Participants were recruited to form a heterogeneous sample with respect to age, gender and socioeconomic background. All interviews were analysed utilising inductive thematic analysis.\r\n\r\nFrom the participants' narratives four themes were identified: 'Concerns and worries in everyday life', 'Supportive and concerned relatives', 'A new way of life-sorrows and advantages' and 'Seize the day-a greater awareness of one\u00b4s mortality'. Participants described how they tried to create a functioning everyday life. They were generally afraid of getting COVID-19 again and concerned about future life, where their lack of energy played a major role. Narratives were diverse regarding to what extent the struggle to cope was experienced as emotionally challenging or not.\r\n\r\nParticipants described an unpredictable recovery after COVID-19, characterised by ups and downs, which created worries concerning their future. In some cases, the worry of getting COVID-19 again was strong enough to keep participants in their homes, as a self-imposed lockdown guarded by anxiety. However, the narratives also revealed gratitude towards being alive and having coped so well. This led to a more positive outlook on life with a greater focus on intrinsic values, close social relations and the deeper meaning of life.", "doi": "10.1371/journal.pone.0287981", "pmid": "37467220", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10355428"}, {"db": "pii", "key": "PONE-D-22-34035"}], "notes": [], "created": "2023-10-04T12:08:26.208Z", "modified": "2023-10-04T12:35:13.421Z"}, {"entity": "publication", "iuid": "84926b3365624d769652f76338c3b874", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84926b3365624d769652f76338c3b874.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84926b3365624d769652f76338c3b874"}}, "title": "Totality of evidence of the effectiveness of repurposed therapies for COVID-19: Can we use real-world studies alongside randomized controlled trials?", "authors": [{"family": "Mandema", "given": "Jaap", "initials": "J"}, {"family": "Montgomery", "given": "Hugh", "initials": "H"}, {"family": "Dron", "given": "Louis", "initials": "L"}, {"family": "Fu", "given": "Shuai", "initials": "S", "orcid": "0000-0003-1889-3030", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f6c25a0a15240dbace467b7b5b2869e.json"}}, {"family": "Russek-Cohen", "given": "Estelle", "initials": "E"}, {"family": "Bromley", "given": "Christina", "initials": "C"}, {"family": "Mouksassi", "given": "Samer", "initials": "S", "orcid": "0000-0002-7152-6654", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f160080128543c0bb3ff50d0c56f091.json"}}, {"family": "Lalonde", "given": "Amy", "initials": "A"}, {"family": "Springford", "given": "Aaron", "initials": "A", "orcid": "0000-0001-7179-9049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa09157725754184ae5d22671b82af21.json"}}, {"family": "Tsai", "given": "Larry", "initials": "L", "orcid": "0000-0002-4787-2100", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/866e5b6ff6b54c2a8ac0d8b7170aef13.json"}}, {"family": "Ambery", "given": "Phil", "initials": "P"}, {"family": "McNair", "given": "Doug", "initials": "D"}, {"family": "Qizilbash", "given": "Nawab", "initials": "N"}, {"family": "Pocock", "given": "Stuart", "initials": "S"}, {"family": "Zariffa", "given": "N\u00e9vine", "initials": "N", "orcid": "0000-0001-7412-2260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b43d74bd08504288860d6a0ad7ea82c3.json"}}], "type": "journal article", "published": "2023-07-19", "journal": {"title": "Clin Transl Sci", "issn": "1752-8062", "issn-l": "1752-8054", "volume": null, "issue": null, "pages": null}, "abstract": "Rapid and robust strategies to evaluate the efficacy and effectiveness of novel and existing pharmacotherapeutic interventions (repurposed treatments) in future pandemics are required. Observational \"real-world studies\" (RWS) can report more quickly than randomized controlled trials (RCTs) and would have value were they to yield reliable results. Both RCTs and RWS were deployed during the coronavirus disease 2019 (COVID-19) pandemic. Comparing results between them offers a unique opportunity to determine the potential value and contribution of each. A learning review of these parallel evidence channels in COVID-19, based on quantitative modeling, can help improve speed and reliability in the evaluation of repurposed therapeutics in a future pandemic. Analysis of all-cause mortality data from 249 observational RWS and RCTs across eight treatment regimens for COVID-19 showed that RWS yield more heterogeneous results, and generally overestimate the effect size subsequently seen in RCTs. This is explained in part by a few study factors: the presence of RWS that are imbalanced for age, gender, and disease severity, and those reporting mortality at 2 weeks or less. Smaller studies of either type contributed negligibly. Analysis of evidence generated sequentially during the pandemic indicated that larger RCTs drive our ability to make conclusive decisions regarding clinical benefit of each treatment, with limited inference drawn from RWS. These results suggest that when evaluating therapies in future pandemics, (1) large RCTs, especially platform studies, be deployed early; (2) any RWS should be large and should have adequate matching of known confounders and long follow-up; (3) reporting standards and data standards for primary endpoints, explanatory factors, and key subgroups should be improved; in addition, (4) appropriate incentives should be in place to enable access to patient-level data; and (5) an overall aggregate view of all available results should be available at any given time.", "doi": "10.1111/cts.13591", "pmid": "37466279", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:10:13.332Z", "modified": "2023-10-04T13:11:17.887Z"}, {"entity": "publication", "iuid": "75b38a566c9a47e8a475fbbdd05169c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/75b38a566c9a47e8a475fbbdd05169c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/75b38a566c9a47e8a475fbbdd05169c5"}}, "title": "Quality of Life in Healthcare Workers during COVID-19-A Longitudinal Study.", "authors": [{"family": "Jungmar Ridell", "given": "Robin", "initials": "R", "orcid": "0009-0001-1877-427X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/248c00c2b3da4b11bb4b7c39e97e899a.json"}}, {"family": "Orvelius", "given": "Lotti", "initials": "L", "orcid": "0000-0002-8641-8656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22194893b9b94b068cda439a33af1b69.json"}}], "type": "journal article", "published": "2023-07-19", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "20", "issue": "14", "pages": null}, "abstract": "The COVID-19 pandemic occurred in 2020, and affected people's daily life worldwide at work and at home. Healthcare workers are a professional group with heavy workloads, and during the COVID-19 pandemic, their burden increased. The literature from earlier outbreaks describes risks for affected mental health in frontline workers, and the main aim of this study is to examine healthcare workers' quality of life during the COVID-19 pandemic. In addition, we sought to assess if there was any difference in working at a pandemic ward compared to anon-pandemic ward. In this longitudinal and descriptive study, a total of 147 healthcare workers assessed their perceived health every third month over one year using the RAND-36 health survey. RAND-36 is a general instrument that consists of 36 questions and is widely used for assessing quality of life. The healthcare workers in this study showed reductions in perceived quality of life during the first six months of the COVID-19 pandemic. Healthcare workers on a pandemic ward reported a lower score in RAND-36 compared to healthcare workers on a non-pandemic ward. Registered nurses and licensed practical nurses seemed more negatively affected in their quality of life than physicians. Compared to data from the general Swedish population, healthcare workers in this study had less energy during this period.", "doi": "10.3390/ijerph20146397", "pmid": "37510629", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10379197"}, {"db": "pii", "key": "ijerph20146397"}], "notes": [], "created": "2023-10-04T12:08:55.593Z", "modified": "2023-10-04T12:45:15.220Z"}, {"entity": "publication", "iuid": "f0d3d0fe64e8498f872585e04df58e78", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f0d3d0fe64e8498f872585e04df58e78.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f0d3d0fe64e8498f872585e04df58e78"}}, "title": "Protective immunity induced by an inhaled SARS-CoV-2 subunit vaccine.", "authors": [{"family": "Elder", "given": "Elizabeth", "initials": "E"}, {"family": "Bangalore Revanna", "given": "Chandrashekar", "initials": "C"}, {"family": "Johansson", "given": "Catharina", "initials": "C"}, {"family": "Wallin", "given": "Robert P A", "initials": "RPA"}, {"family": "Sj\u00f6dahl", "given": "Johan", "initials": "J"}, {"family": "Winqvist", "given": "Ola", "initials": "O"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}], "type": "journal article", "published": "2023-07-19", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null, "volume": "41", "issue": "32", "pages": "4743-4751"}, "abstract": "Targeting the site of infection is a promising strategy for improving vaccine effectivity. To date, licensed COVID-19 vaccines have been administered intramuscularly despite the fact that SARS-CoV-2 is a respiratory virus. Here, we aim to induce local protective mucosal immune responses with an inhaled subunit vaccine candidate, ISR52, based on the SARS-CoV-2 Spike S1 protein. When tested in a lethal challenge hACE2 transgenic SARS-CoV-2 mouse model, intranasal and intratracheal administration of ISR52 provided superior protection against severe infection, compared to the subcutaneous injection of the vaccine. Interestingly for a protein-based vaccine, inhaled ISR52 elicited both CD4 and CD8 T-cell Spike-specific responses that were maintained for at least 6 months in wild-type mice. Induced IgG and IgA responses cross-reacting with several SARS- CoV-2 variants of concern were detected in the lung and in serum and protected animals displayed neutralizing antibodies. Based on our results, we are developing ISR52 as a dry powder formulation for inhalation, that does not require cold-chain distribution or the use of needle administration, for evaluation in a Phase I/II clinical trial.", "doi": "10.1016/j.vaccine.2023.06.015", "pmid": "37353452", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10242152"}, {"db": "pii", "key": "S0264-410X(23)00684-9"}], "notes": [], "created": "2023-10-04T09:29:58.130Z", "modified": "2023-10-04T09:42:25.916Z"}, {"entity": "publication", "iuid": "53d5d83a2a0443efb9a916f3b7ae1622", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53d5d83a2a0443efb9a916f3b7ae1622.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53d5d83a2a0443efb9a916f3b7ae1622"}}, "title": "European Society of Breast Imaging (EUSOBI) guidelines on the management of axillary lymphadenopathy after COVID-19 vaccination: 2023 revision.", "authors": [{"family": "Schiaffino", "given": "Simone", "initials": "S"}, {"family": "Pinker", "given": "Katja", "initials": "K", "orcid": "0000-0002-2722-7331", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a70e813e2dcb4580a6df060773885849.json"}}, {"family": "Cozzi", "given": "Andrea", "initials": "A"}, {"family": "Magni", "given": "Veronica", "initials": "V"}, {"family": "Athanasiou", "given": "Alexandra", "initials": "A"}, {"family": "Baltzer", "given": "Pascal A T", "initials": "PAT"}, {"family": "Camps Herrero", "given": "Julia", "initials": "J"}, {"family": "Clauser", "given": "Paola", "initials": "P"}, {"family": "Fallenberg", "given": "Eva M", "initials": "EM"}, {"family": "Forrai", "given": "Gabor", "initials": "G"}, {"family": "Fuchsj\u00e4ger", "given": "Michael H", "initials": "MH"}, {"family": "Gilbert", "given": "Fiona J", "initials": "FJ"}, {"family": "Helbich", "given": "Thomas", "initials": "T"}, {"family": "Kilburn-Toppin", "given": "Fleur", "initials": "F"}, {"family": "Kuhl", "given": "Christiane K", "initials": "CK"}, {"family": "Lesaru", "given": "Mihai", "initials": "M"}, {"family": "Mann", "given": "Ritse M", "initials": "RM"}, {"family": "Panizza", "given": "Pietro", "initials": "P"}, {"family": "Pediconi", "given": "Federica", "initials": "F"}, {"family": "Sardanelli", "given": "Francesco", "initials": "F"}, {"family": "Sella", "given": "Tamar", "initials": "T"}, {"family": "Thomassin-Naggara", "given": "Isabelle", "initials": "I"}, {"family": "Zackrisson", "given": "Sophia", "initials": "S"}, {"family": "Pijnappel", "given": "Ruud M", "initials": "RM"}], "type": "journal article", "published": "2023-07-19", "journal": {"title": "Insights Imaging", "issn": "1869-4101", "issn-l": null, "volume": "14", "issue": "1", "pages": "126"}, "abstract": "Axillary lymphadenopathy is a common side effect of COVID-19 vaccination, leading to increased imaging-detected asymptomatic and symptomatic unilateral axillary lymphadenopathy. This has threatened to negatively impact the workflow of breast imaging services, leading to the release of ten recommendations by the European Society of Breast Imaging (EUSOBI) in August 2021. Considering the rapidly changing scenario and data scarcity, these initial recommendations kept a highly conservative approach. As of 2023, according to newly acquired evidence, EUSOBI proposes the following updates, in order to reduce unnecessary examinations and avoid delaying necessary examinations. First, recommendation n. 3 has been revised to state that breast examinations should not be delayed or rescheduled because of COVID-19 vaccination, as evidence from the first pandemic waves highlights how delayed or missed screening tests have a negative effect on breast cancer morbidity and mortality, and that there is a near-zero risk of subsequent malignant findings in asymptomatic patients who have unilateral lymphadenopathy and no suspicious breast findings. Second, recommendation n. 7 has been revised to simplify follow-up strategies: in patients without breast cancer history and no imaging findings suspicious for cancer, symptomatic and asymptomatic imaging-detected unilateral lymphadenopathy on the same side of recent COVID-19 vaccination (within 12 weeks) should be classified as a benign finding (BI-RADS 2) and no further work-up should be pursued. All other recommendations issued by EUSOBI in 2021 remain valid.", "doi": "10.1186/s13244-023-01453-2", "pmid": "37466753", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Imaging": null}, "xrefs": [{"db": "pmc", "key": "PMC10356714"}, {"db": "pii", "key": "10.1186/s13244-023-01453-2"}], "notes": [], "created": "2023-10-04T12:10:08.468Z", "modified": "2023-10-04T13:09:53.088Z"}, {"entity": "publication", "iuid": "f224c212d8b649c6930ea0c2c55cb72c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f224c212d8b649c6930ea0c2c55cb72c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f224c212d8b649c6930ea0c2c55cb72c"}}, "title": "A novel indicator of selection in utero.", "authors": [{"family": "Catalano", "given": "Ralph", "initials": "R", "orcid": "0000-0001-7240-415X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ccf81f67c4f46dc92acca88a7344cc9.json"}}, {"family": "Bruckner", "given": "Tim A", "initials": "TA"}, {"family": "Gemmill", "given": "Alison", "initials": "A", "orcid": "0000-0001-5879-9730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dca36e3db9724dce8360c5f7b362151d.json"}}, {"family": "Casey", "given": "Joan A", "initials": "JA", "orcid": "0000-0002-9809-4695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e83f9b0e8a194572a5769025b1fe611f.json"}}, {"family": "Margerison", "given": "Claire", "initials": "C", "orcid": "0000-0003-0692-2252", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06be6014da274b2886af1733870d98b0.json"}}, {"family": "Hartig", "given": "Terry", "initials": "T"}], "type": "journal article", "published": "2023-07-19", "journal": {"title": "Evol Med Public Health", "issn": "2050-6201", "issn-l": null, "volume": "11", "issue": "1", "pages": "244-250"}, "abstract": "Selection in utero predicts that population stressors raise the standard for how quickly fetuses must grow to avoid spontaneous abortion. Tests of this prediction must use indirect indicators of fetal loss in birth cohorts because vital statistics systems typically register fetal deaths at the 20th week of gestation or later, well after most have occurred. We argue that tests of selection in utero would make greater progress if researchers adopted an indicator of selection against slow-growing fetuses that followed from theory, allowed sex-specific tests and used readily available data. We propose such an indicator and assess its validity as a dependent variable by comparing its values among monthly birth cohorts before, and during, the first 10 months of the COVID-19 pandemic in Sweden.\r\n\r\nWe apply Box-Jenkins methods to 50 pre-pandemic birth cohorts (i.e., December 2016 through January 2020) and use the resulting transfer functions to predict counterfactual values in our suggested indicator for selection for ten subsequent birth cohorts beginning in February 2020. We then plot all 60 residual values as well as their 95% detection interval. If birth cohorts in gestation at the onset of the pandemic lost more slow-growing fetuses than expected from history, more than one of the last 10 (i.e. pandemic-exposed) residuals would fall below the detection interval.\r\n\r\nFour of the last 10 residuals of our indicator for males and for females fell below the 95% detection interval.\r\n\r\nConsistent with selection in utero, Swedish birth cohorts in gestation at the outset of the COVID-19 pandemic included fewer than expected infants who grew slowly in utero.", "doi": "10.1093/emph/eoad018", "pmid": "37485055", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10360163"}, {"db": "pii", "key": "eoad018"}], "notes": [], "created": "2023-10-04T12:10:36.917Z", "modified": "2023-10-04T13:27:54.501Z"}, {"entity": "publication", "iuid": "861bb5ecaf5e4ceca3d0fe78c08c0c07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/861bb5ecaf5e4ceca3d0fe78c08c0c07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/861bb5ecaf5e4ceca3d0fe78c08c0c07"}}, "title": "Relative effectiveness of monovalent and bivalent mRNA boosters in preventing severe COVID-19 due to omicron BA.5 infection up to 4 months post-administration in people aged 60 years or older in Italy: a retrospective matched cohort study.", "authors": [{"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Sacco", "given": "Chiara", "initials": "C"}, {"family": "Fotakis", "given": "Emmanouil Alexandros", "initials": "EA"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Bressi", "given": "Marco", "initials": "M"}, {"family": "Rota", "given": "Maria Cristina", "initials": "MC"}, {"family": "Petrone", "given": "Daniele", "initials": "D"}, {"family": "Siddu", "given": "Andrea", "initials": "A"}, {"family": "Fedele", "given": "Giorgio", "initials": "G"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Palamara", "given": "Anna Teresa", "initials": "AT"}, {"family": "Brusaferro", "given": "Silvio", "initials": "S"}, {"family": "Rezza", "given": "Giovanni", "initials": "G"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}], "type": "journal article", "published": "2023-07-18", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Limited evidence is available on the additional protection conferred by second mRNA vaccine boosters against severe COVID-19 caused by omicron BA.5 infection, and whether the adapted bivalent boosters provide additional protection compared with the monovalent ones. In this study, we aimed to estimate the relative effectiveness of a second booster with monovalent or bivalent mRNA vaccines against severe COVID-19 in Italy.\r\n\r\nLinking data from the Italian vaccination registry and the SARS-CoV-2 surveillance system, between Sept 12, 2022, and Jan 7, 2023, we matched 1:1 each person aged 60 years or older receiving a second booster with a person who had received the first booster only at least 120 days earlier. We used hazard ratios, estimated through Cox proportional hazard models, to compare the hazard of severe COVID-19 between the first booster group and each type of second booster (monovalent mRNA vaccine targeting the original strain of SARS-CoV-2, bivalent mRNA vaccine targeting the original strain plus omicron BA.1 [bivalent original/BA.1], and bivalent mRNA vaccine targeting the original strain plus omicron BA.4 and BA.5 [bivalent original/BA.4-5]). Relative vaccine effectiveness (rVE) was calculated as (1-hazard ratio) \u00d7 100.\r\n\r\nWe analysed a total of 2 129 559 matched pairs. The estimated rVE against severe COVID-19 with the bivalent original/BA.4-5 booster was 50\u00b76% (95% CI 46\u00b70-54\u00b78) in the overall time interval 14-118 days post-administration. Overall, rVE was 49\u00b73% (43\u00b76-54\u00b74) for the bivalent original/BA.1 booster and 26\u00b79% (11\u00b78-39\u00b73) for the monovalent booster. For the bivalent original/BA.4-5 booster, we did not observe relevant differences in rVE between the 60-79-year age group (overall, 53\u00b76%; 46\u00b78-59\u00b75) and those aged 80 years or older (overall, 48\u00b73%; 41\u00b79-54\u00b70).\r\n\r\nThese findings suggest that a second booster with mRNA vaccines provides additional protection against severe COVID-19 due to omicron BA.5 (the predominant circulating subvariant in Italy during the study period) in people aged 60 years or older. Although rVE decreased over time, a second booster with the original/BA.4-5 mRNA vaccine, currently the most used in Italy, was found to be still providing protection 4 months post-administration.\r\n\r\nNextGenerationEU-MUR-PNRR Extended Partnership initiative on Emerging Infectious Diseases (project number PE00000007, INF-ACT).\r\n\r\nFor the Italian translation of the abstract see Supplementary Materials section.", "doi": "10.1016/S1473-3099(23)00374-2", "pmid": "37478877", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(23)00374-2"}], "notes": [], "created": "2023-10-04T12:08:12.943Z", "modified": "2023-10-04T12:30:26.922Z"}, {"entity": "publication", "iuid": "a06d396df52745dfb22dc30368de75ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a06d396df52745dfb22dc30368de75ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a06d396df52745dfb22dc30368de75ef"}}, "title": "Practices of Care in Participatory Design With Older Adults During the COVID-19 Pandemic: Digitally Mediated Study.", "authors": [{"family": "Paluch", "given": "Richard", "initials": "R", "orcid": "0000-0003-0420-7028", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50123f4f07fd4f9bac7aec9cfaaa4618.json"}}, {"family": "Cerna", "given": "Katerina", "initials": "K", "orcid": "0000-0001-8796-343X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31750b30f1584f33abd4e31d8fac84a2.json"}}, {"family": "Kirschsieper", "given": "Dennis", "initials": "D", "orcid": "0009-0000-9081-0418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e3bc92c91af411eb29cfbb736e98389.json"}}, {"family": "M\u00fcller", "given": "Claudia", "initials": "C", "orcid": "0000-0001-8534-546X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06fab12a9dd148a3b68fc7f2524d5272.json"}}], "type": "journal article", "published": "2023-07-17", "journal": {"title": "J Med Internet Res", "issn": "1438-8871", "issn-l": null, "volume": "25", "issue": null, "pages": "e45750"}, "abstract": "Participatory Design (PD), albeit an established approach in User-Centered Design, comes with specific challenges when working with older adults as research participants. Addressing these challenges relates to the reflection and negotiation of the positionalities of the researchers and research participants and includes various acts of giving and receiving help. During the COVID-19 pandemic, facets of positionalities and (mutual) care became particularly evident in qualitative and participatory research settings.\r\n\r\nThe aim of this paper was to systematically analyze care practices of participatory (design) research, which are to different extents practices of the latter. Using a multiyear PD project with older people that had to take place remotely over many months, we specify different practices of care; how they relate to collaborative work in the design project; and represent foundational practices for sustainable, long-term co-design. Our research questions were \"How can digitally-mediated PD work during COVID-19 and can we understand such digital PD as 'care'?\"\r\n\r\nOur data comes from the Joint Programming Initiative \"More Years, Better Lives\" (JPI MYBL), a European Union project that aims to promote digital literacy and technology appropriation among older adults in domestic settings. It targeted the cocreation, by older adults and university researchers, of a mobile demo kit website with cocreated resources, aimed at improving the understanding of use options of digital tools. Through a series of workshops, a range of current IT products was explored by a group of 21 older adults, which served as the basis for joint cocreative work on generating design ideas and prototypes. We reflect on the PD process and examine how the actors enact and manifest care.\r\n\r\nThe use of digital technology allowed the participatory project to continue during the COVID-19 pandemic and accentuated the digital skills of older adults and the improvement of digital literacy as part of \"care.\" We provide empirically based evidence of PD with older adults developing digital literacy and sensitizing concepts, based on the notion of care by Tronto for differentiating aspects and processes of care. The data suggest that it is not enough to focus solely on the technologies and how they are used; it is also necessary to focus on the social structures in which help is available and in which technologies offer opportunities to do care work.\r\n\r\nWe document that the cocreation of different digital media tools can be used to provide a community with mutual care. Our study demonstrates how research participants effectively enact different forms of care and how such \"care\" is a necessary basis for a genuinely participatory approach, which became especially meaningful as a form of support during COVID-19. We reflect on how notions of \"care\" and \"caring\" that were central to the pandemic response are also central to PD.", "doi": "10.2196/45750", "pmid": "37459177", "labels": {"Category: Health": null, "Type: Journal article": null, "Funder: H2020": null}, "xrefs": [{"db": "pmc", "key": "PMC10390970"}, {"db": "pii", "key": "v25i1e45750"}], "notes": [], "created": "2023-10-04T12:09:48.554Z", "modified": "2023-10-04T13:02:21.842Z"}, {"entity": "publication", "iuid": "a6a1b3cc2625453bb09de11b4df67c4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6a1b3cc2625453bb09de11b4df67c4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6a1b3cc2625453bb09de11b4df67c4d"}}, "title": "Comparing severe COVID-19 outcomes of first and second/third waves: a prospective single-centre cohort study of health-related quality of life and pulmonary outcomes 6 months after infection.", "authors": [{"family": "Darlington", "given": "Pernilla", "initials": "P", "orcid": "0000-0002-3411-8838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ded6431af104890a284d0cd458bd8d4.json"}}, {"family": "Ro\u00ebl", "given": "Mari", "initials": "M"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Hanna", "given": "Gabriel", "initials": "G"}, {"family": "Hedman", "given": "Anders", "initials": "A"}, {"family": "Joelsson-Alm", "given": "Eva", "initials": "E"}, {"family": "Schandl", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2023-07-17", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "7", "pages": "e071394"}, "abstract": "We aimed to compare long-term outcomes in intensive care unit (ICU) survivors between the first and second/third waves of the COVID-19 pandemic. More specifically, to assess health-related quality of life (HRQL) and respiratory health 6 months post-ICU and to study potential associations between patient characteristic and treatment variables regarding 6-month outcomes.\r\n\r\nProspective cohort study.\r\n\r\nSingle-centre study of adult COVID-19 patients with respiratory distress admitted to two Swedish ICUs during the first wave (1 March 2020-1 September 2020) and second/third waves (2 September 2020- 1 August 2021) with follow-up approximately 6 months after ICU discharge.\r\n\r\nCritically ill COVID-19 patients who survived for at least 90 days.\r\n\r\nHRQL, extent of residual changes on chest CT scan and pulmonary function were compared between the waves. General linear regression and multivariable logistic regression were used to present mean score differences (MSD) and ORs with 95% CIs.\r\n\r\nOf the 456 (67%) critically ill COVID-19 patients who survived at least 90 days, 278 (61%) were included in the study. Six months after ICU discharge, HRQL was similar between survivors in the pandemic waves, except that the second/third wave survivors had better role physical (MSD 20.2, 95% CI 7.3 to 33.1, p<0.01) and general health (MSD 7.2, 95% CI 0.7 to 13.6, p=0.03) and less bodily pain (MSD 12.2, 95% CI 3.6 to 20.8, p<0.01), while first wave survivors had better diffusing capacity of the lungs for carbon monoxide (OR 1.9, 95% CI 1.1 to 3.5, p=0.03).\r\n\r\nThis study indicates that even though intensive care treatment strategies have changed with time, there are few differences in long-term HRQL and respiratory health seems to remain at 6 months for patients surviving critical COVID-19 in the first and second/third waves of the pandemic.", "doi": "10.1136/bmjopen-2022-071394", "pmid": "37460259", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10357304"}, {"db": "pii", "key": "bmjopen-2022-071394"}], "notes": [], "created": "2023-10-04T12:09:03.426Z", "modified": "2023-10-04T12:48:03.979Z"}, {"entity": "publication", "iuid": "66216a329eff46a9a193603cec068305", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66216a329eff46a9a193603cec068305.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66216a329eff46a9a193603cec068305"}}, "title": "Organised crisis volunteers, COVID-19, and the political steering of crisis management in Sweden.", "authors": [{"family": "Wimelius", "given": "Malin E", "initials": "ME"}, {"family": "Strandh", "given": "Veronica", "initials": "V"}], "type": "journal article", "published": "2023-07-14", "journal": {"title": "Disasters", "issn": "1467-7717", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "This paper explores and analyses the activities of Swedish organised crisis volunteers during the COVID-19 pandemic. Based on a questionnaire and interviews, it sets out to answer two research questions on what characterised organised volunteerism during the pandemic, how organised volunteers experienced cooperation with local public actors, and how they viewed political steering. The paper contributes to a growing literature on the role of volunteers and links that role to views on political steering, something that is rarely done in disaster research. Sweden is a useful case study because of how COVID-19 was managed, as well as because there are organised crisis volunteers and a debate is occurring on how the national system is steered. The paper shows how organised volunteers adapted to changing needs and adopted new roles, that experiences of cooperation with local authorities varied, and that calls were made for a stronger national leadership and for more explicit central political steering.", "doi": "10.1111/disa.12604", "pmid": "37450584", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:09:22.610Z", "modified": "2023-10-04T12:51:45.561Z"}, {"entity": "publication", "iuid": "02e7c304712a42c0a4343afa18dbbaf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02e7c304712a42c0a4343afa18dbbaf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02e7c304712a42c0a4343afa18dbbaf3"}}, "title": "Effect of the COVID-19 pandemic on emergency department attendances for pediatric injuries in Mozambique's central hospitals: an interrupted time series and a comparison within the restriction periods between 2019 and 2020.", "authors": [{"family": "Amado", "given": "Vanda", "initials": "V", "orcid": "0000-0002-8839-984X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e564fcb429b45c8932476d0df8d086f.json"}}, {"family": "Moller", "given": "Jette", "initials": "J"}, {"family": "Couto", "given": "Maria Tereza", "initials": "MT"}, {"family": "Wallis", "given": "Lee", "initials": "L"}, {"family": "Laflamme", "given": "Lucie", "initials": "L"}], "type": "journal article", "published": "2023-07-14", "journal": {"title": "Trauma Surg Acute Care Open", "issn": "2397-5776", "issn-l": null, "volume": "8", "issue": "1", "pages": "e001062"}, "abstract": "Hospital-based studies indicate that restriction measures imposed during the COVID-19 pandemic have affected the number and characteristics of pediatric injuries. However, few studies have been conducted in resource-poor countries. This study aimed to determine whether injury-related emergency department (ED) attendances in Mozambique were affected during the restriction periods in 2020 and how the pattern of injury changed.\r\n\r\nMozambique faced two restriction periods in 2020. An interrupted time series was applied to weekly data of pediatric injuries from the ED records of four central hospitals in Mozambique in 2019 and 2020. Weekly numbers of injuries were modeled using a Poisson regression model to estimate the effect of COVID-19 restrictions on trends over calendar time. Then, for each restriction period, differences in injury mechanisms, severity, need for surgery, and intensive care unit (ICU) attendances were compared between 2019 and 2020.\r\n\r\nDuring the 76 weeks preceding the restrictions, there was a stable trend in ED attendances. The weekly number dropped by 48.7% after implementation of the first restrictions. By the end of 2020, the weekly numbers were back to the levels observed before the restrictions. Road traffic injuries (RTIs) and falls dropped during the first restriction period and RTIs and burns during the second. There was an increase of 80% in ICU attendances in all periods of 2020 at three hospitals during the first and second restriction periods.\r\n\r\nThe COVID-19 restrictions yielded a reduction in the weekly number of pediatric injuries seen at Mozambique's central hospitals, above all RTIs and falls. The drop reflects reductions in visits most importantly for RTIs, falls, and burns, but was accompanied by an increase in the proportion of ICU cases. This effect was not maintained when the restrictions were relaxed. Whether this reflects reduced exposure to injury or hesitancy to seek care remains to be determined.\r\n\r\nLevel III, retrospective study with up to two negative criteria.", "doi": "10.1136/tsaco-2022-001062", "pmid": "37484836", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10350904"}, {"db": "pii", "key": "tsaco-2022-001062"}], "notes": [], "created": "2023-10-04T12:10:28.808Z", "modified": "2023-10-04T13:14:11.870Z"}, {"entity": "publication", "iuid": "5711df6665da4420973aa4d6e5d0592e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5711df6665da4420973aa4d6e5d0592e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5711df6665da4420973aa4d6e5d0592e"}}, "title": "The influence of COVID-19 risk perception and vaccination status on the number of social contacts across Europe: insights from the CoMix study.", "authors": [{"family": "Wambua", "given": "James", "initials": "J"}, {"family": "Loedy", "given": "Neilshan", "initials": "N"}, {"family": "Jarvis", "given": "Christopher I", "initials": "CI"}, {"family": "Wong", "given": "Kerry L M", "initials": "KLM"}, {"family": "Faes", "given": "Christel", "initials": "C"}, {"family": "Grah", "given": "Rok", "initials": "R"}, {"family": "Prasse", "given": "Bastian", "initials": "B"}, {"family": "Sandmann", "given": "Frank", "initials": "F"}, {"family": "Niehus", "given": "Rene", "initials": "R"}, {"family": "Johnson", "given": "Helen", "initials": "H"}, {"family": "Edmunds", "given": "W John", "initials": "WJ"}, {"family": "Beutels", "given": "Philippe", "initials": "P"}, {"family": "Hens", "given": "Niel", "initials": "N"}, {"family": "Coletti", "given": "Pietro", "initials": "P"}], "type": "journal article", "published": "2023-07-13", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "23", "issue": "1", "pages": "1350"}, "abstract": "The SARS-CoV-2 transmission dynamics have been greatly modulated by human contact behaviour. To curb the spread of the virus, global efforts focused on implementing both Non-Pharmaceutical Interventions (NPIs) and pharmaceutical interventions such as vaccination. This study was conducted to explore the influence of COVID-19 vaccination status and risk perceptions related to SARS-CoV-2 on the number of social contacts of individuals in 16 European countries.\r\n\r\nWe used data from longitudinal surveys conducted in the 16 European countries to measure social contact behaviour in the course of the pandemic. The data consisted of representative panels of participants in terms of gender, age and region of residence in each country. The surveys were conducted in several rounds between December 2020 and September 2021 and comprised of 29,292 participants providing a total of 111,103 completed surveys. We employed a multilevel generalized linear mixed effects model to explore the influence of risk perceptions and COVID-19 vaccination status on the number of social contacts of individuals.\r\n\r\nThe results indicated that perceived severity played a significant role in social contact behaviour during the pandemic after controlling for other variables (p-value < 0.001). More specifically, participants who had low or neutral levels of perceived severity reported 1.25 (95% Confidence intervals (CI) 1.13 - 1.37) and 1.10 (95% CI 1.00 - 1.21) times more contacts compared to those who perceived COVID-19 to be a serious illness, respectively. Additionally, vaccination status was also a significant predictor of contacts (p-value < 0.001), with vaccinated individuals reporting 1.31 (95% CI 1.23 - 1.39) times higher number of contacts than the non-vaccinated. Furthermore, individual-level factors played a more substantial role in influencing contact behaviour than country-level factors.\r\n\r\nOur multi-country study yields significant insights on the importance of risk perceptions and vaccination in behavioral changes during a pandemic emergency. The apparent increase in social contact behaviour following vaccination would require urgent intervention in the event of emergence of an immune escaping variant.", "doi": "10.1186/s12889-023-16252-z", "pmid": "37442987", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Social Science & Humanities": null, "Funder: H2020": null}, "xrefs": [{"db": "pmc", "key": "PMC10347859"}, {"db": "pii", "key": "10.1186/s12889-023-16252-z"}], "notes": [], "created": "2023-10-04T12:08:18.368Z", "modified": "2023-10-04T12:32:22.312Z"}, {"entity": "publication", "iuid": "8ecaa819bcdc4d49b92adfe225613ff0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ecaa819bcdc4d49b92adfe225613ff0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ecaa819bcdc4d49b92adfe225613ff0"}}, "title": "Individual-level precision diagnosis for coronavirus disease 2019 related severe outcome: an early study in New York.", "authors": [{"family": "Huang", "given": "Chaorui C", "initials": "CC"}, {"family": "Xu", "given": "Hong", "initials": "H"}], "type": "journal article", "published": "2023-07-13", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "11317"}, "abstract": "Because of inadequate information provided by the on-going population level risk analyses for Coronavirus disease 2019 (COVID-19), this study aimed to evaluate the risk factors and develop an individual-level precision diagnostic method for COVID-19 related severe outcome in New York State (NYS) to facilitate early intervention and predict resource needs for patients with COVID-19. We analyzed COVID-19 related hospital encounter and hospitalization in NYS using Statewide Planning and Research Cooperative System hospital discharge dataset. Logistic regression was performed to evaluate the risk factors for COVID-19 related mortality. We proposed an individual-level precision diagnostic method by taking into consideration of the different weights and interactions of multiple risk factors. Age was the greatest risk factor for COVID-19 related fatal outcome. By adding other demographic variables, dyspnea or hypoxemia and multiple chronic co-morbid conditions, the model predictive accuracy was improved to 0.85 (95% CI 0.84-0.85). We selected cut-off points for predictors and provided a general recommendation to categorize the levels of risk for COVID-19 related fatal outcome, which can facilitate the individual-level diagnosis and treatment, as well as medical resource prediction. We further provided a use case of our method to evaluate the feasibility of public health policy for monoclonal antibody therapy.", "doi": "10.1038/s41598-023-35966-z", "pmid": "37443363", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10344938"}, {"db": "pii", "key": "10.1038/s41598-023-35966-z"}], "notes": [], "created": "2023-10-04T12:08:20.888Z", "modified": "2023-10-04T12:33:28.301Z"}, {"entity": "publication", "iuid": "0a3a113ae8d94215aa2d5d077722c049", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a3a113ae8d94215aa2d5d077722c049.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a3a113ae8d94215aa2d5d077722c049"}}, "title": "Post COVID-19 symptoms are common, also among young adults in the general population.", "authors": [{"family": "Mogensen", "given": "Ida", "initials": "I"}, {"family": "Ekstr\u00f6m", "given": "Sandra", "initials": "S"}, {"family": "Hallberg", "given": "Jenny", "initials": "J"}, {"family": "Georgelis", "given": "Antonios", "initials": "A"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Bergstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Kull", "given": "Inger", "initials": "I"}], "type": "journal article", "published": "2023-07-12", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "11300"}, "abstract": "Post coronavirus disease-19 (post COVID-19) is mainly studied in clinical populations and less is known about post COVID-19 in a young general population. The aim of the study is to investigate the prevalence and symptoms of post COVID-19 and its potential risk factors in young adults. Participants from the Swedish population-based birth cohort BAMSE were included (n = 2022, mean age 26.5 years). Post COVID-19 was assessed through a questionnaire and defined as symptoms after confirmed COVID-19 (registry-based or self-reported positive test) lasting for \u2265 2 months. In total, 681 participants had had confirmed COVID-19. Among them, 112 (16.5%) fulfilled the definition of post COVID-19 (17.8% in females, 14.5% in males, p = 0.26). The most common post COVID-19 symptoms were altered smell and taste (68.8%), dyspnea (33.7%) and fatigue (30.4%). Overall, no major risk factors for post COVID-19 were identified except for being bedbound during COVID-19. However, asthma and rhinitis were associated with the post COVID-19 symptom dyspnea, migraine with altered smell and taste, and lower self-rated health with fatigue. In conclusion, post COVID-19 symptoms are common, also among young adults in the general population. Although not life-threatening, it could have a considerable impact on public health due to the high prevalence and long-term symptoms.", "doi": "10.1038/s41598-023-38315-2", "pmid": "37438424", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC10338459"}, {"db": "pii", "key": "10.1038/s41598-023-38315-2"}], "notes": [], "created": "2023-07-13T11:31:58.051Z", "modified": "2023-10-04T12:29:26.665Z"}, {"entity": "publication", "iuid": "24523286d51a489ab3267bcf49c947b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24523286d51a489ab3267bcf49c947b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24523286d51a489ab3267bcf49c947b4"}}, "title": "Lessons from COVID-19 for Pandemic Preparedness: Proceedings from a Multi-Stakeholder Think Tank.", "authors": [{"family": "Narayanasamy", "given": "Shanti", "initials": "S", "orcid": "0000-0002-6667-2868", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53cc5ca9db8d49678370dbaad3d91ac0.json"}}, {"family": "Curtis", "given": "Lesley H", "initials": "LH"}, {"family": "Hernandez", "given": "Adrian F", "initials": "AF"}, {"family": "Woods", "given": "Christopher W", "initials": "CW"}, {"family": "Moody", "given": "M Anthony", "initials": "MA"}, {"family": "Sulkowski", "given": "Mark", "initials": "M"}, {"family": "Turbett", "given": "Sarah E", "initials": "SE"}, {"family": "Baden", "given": "Lindsey R", "initials": "LR"}, {"family": "Gulick", "given": "Roy M", "initials": "RM"}, {"family": "Pau", "given": "Alice K", "initials": "AK"}, {"family": "Adam", "given": "Stacey J", "initials": "SJ"}, {"family": "Marks", "given": "Peter", "initials": "P"}, {"family": "Stockbridge", "given": "Norman L", "initials": "NL"}, {"family": "Dobbins", "given": "John R", "initials": "JR"}, {"family": "Krofah", "given": "Esther", "initials": "E"}, {"family": "Leav", "given": "Brett", "initials": "B"}, {"family": "Pang", "given": "Phil", "initials": "P"}, {"family": "Roessig", "given": "Lothar", "initials": "L"}, {"family": "Vedin", "given": "Ola", "initials": "O"}, {"family": "Waldstreicher", "given": "Joanne", "initials": "J"}, {"family": "Berman", "given": "Stacey Cromer", "initials": "SC"}, {"family": "Cremisi", "given": "Henry", "initials": "H"}, {"family": "Schofield", "given": "Lesley", "initials": "L"}, {"family": "Gandhi", "given": "Rajesh T", "initials": "RT"}, {"family": "Naggie", "given": "Susanna", "initials": "S"}], "type": "journal article", "published": "2023-07-12", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "issn-l": "1058-4838", "volume": null, "issue": null, "pages": null}, "abstract": "While the Coronavirus Disease 2019 (COVID-19) pandemic continues to present global challenges, sufficient time has passed to reflect on lessons learned and use those insights to inform policy and approaches to prepare for the next pandemic. In May 2022, the Duke Clinical Research Institute (DCRI) convened a Think Tank with thought-leaders from academia, clinical practice, the pharmaceutical industry, patient advocacy, the National Institutes of Health, the US Food and Drug Administration (FDA), and Centers for Disease Control and Prevention (CDC), to share firsthand, expert knowledge of the insights gained from the COVID-19 pandemic and how this acquired knowledge can help inform the next pandemic response. The Think Tank focused on pandemic preparedness, therapeutics, vaccines, and challenges related to clinical trial design and scale-up during the early phase of a pandemic. Based on the multi-faceted discussions, we outline ten key steps to an improved and equitable pandemic response.", "doi": "10.1093/cid/ciad418", "pmid": "37435958", "labels": {"Category: Other": null, "Type: Other": null}, "xrefs": [{"db": "pii", "key": "7223127"}], "notes": [], "created": "2023-10-04T12:10:24.038Z", "modified": "2023-10-04T13:12:14.203Z"}, {"entity": "publication", "iuid": "f0eee6262116469689fc2cacd6e9a821", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f0eee6262116469689fc2cacd6e9a821.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f0eee6262116469689fc2cacd6e9a821"}}, "title": "Additive effects of booster mRNA vaccination and SARS-CoV-2 Omicron infection on T cell immunity across immunocompromised states.", "authors": [{"family": "M\u00fcller", "given": "Thomas R", "initials": "TR", "orcid": "0000-0001-5331-5522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28e705f82ca64e698015b577d25e991c.json"}}, {"family": "Sekine", "given": "Takuya", "initials": "T", "orcid": "0000-0001-7649-0593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a234e0d77c145aa8d23b89fde1c5883.json"}}, {"family": "Trubach", "given": "Darya", "initials": "D", "orcid": "0009-0005-7445-9281", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09dcd62967fe432bbc292f3a10f0458d.json"}}, {"family": "Niessl", "given": "Julia", "initials": "J", "orcid": "0000-0001-8852-1924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70aba42c7f0b400eba1a226ee193d9fd.json"}}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Bergman", "given": "Peter", "initials": "P", "orcid": "0000-0003-3306-3713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15b7290255814a7b9a1a97c3cdb2fc26.json"}}, {"family": "Blennow", "given": "Ola", "initials": "O", "orcid": "0000-0002-7167-7882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2318c3973e66443aa14fceca0908d127.json"}}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Mielke", "given": "Stephan", "initials": "S", "orcid": "0000-0002-8325-9215", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6f17a7cc4774614a3ad5ea9c910d75a.json"}}, {"family": "Nowak", "given": "Piotr", "initials": "P", "orcid": "0000-0003-2747-0734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1d81fdccf9e424fa99ea5227b031843.json"}}, {"family": "Vesterbacka", "given": "Jan", "initials": "J"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Olofsson", "given": "Anna", "initials": "A", "orcid": "0000-0002-7479-315X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b3cfdb6d9cc47e2ad2377d5fe51ca4a.json"}}, {"family": "Amaya Hernandez", "given": "Susana Patricia", "initials": "SP", "orcid": "0000-0003-4425-8145", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a28fef26f85d42d88cea8ea68ba0c7d0.json"}}, {"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Cai", "given": "Curtis", "initials": "C", "orcid": "0000-0002-3490-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52ab789751014f46b6b995a1cdef57a3.json"}}, {"family": "S\u00f6derdahl", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-4423-2458", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e23b3e831934cd786a15cb2183e810e.json"}}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE", "orcid": "0000-0003-1907-3392", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26a3bf24bd044fbda8ffa0c89974bdfe.json"}}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K", "orcid": "0000-0001-7679-9494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02d4d3d9ccc547f7ab18ba69493f6a34.json"}}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M", "orcid": "0000-0002-3793-4064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4bc179656eb442f9ac9dc72c8c6841d.json"}}, {"family": "Ljungman", "given": "Per", "initials": "P", "orcid": "0000-0002-8281-3245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4546eb504184683ab712eee858ea9cb.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Karlsson", "given": "Annika C", "initials": "AC", "orcid": "0000-0002-2028-8393", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9abf28110888427497db1e4abf6ff71d.json"}}, {"family": "Saini", "given": "Sunil Kumar", "initials": "SK", "orcid": "0000-0003-3382-9432", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ad140b13bdd4cd68cf422454b24c29f.json"}}, {"family": "Aleman", "given": "Soo", "initials": "S", "orcid": "0000-0003-0461-4870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b0edb2db8d840989936f67047ce91de.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}], "type": "journal article", "published": "2023-07-12", "journal": {"title": "Sci Transl Med", "issn": "1946-6242", "issn-l": null, "volume": "15", "issue": "704", "pages": "eadg9452"}, "abstract": "Suboptimal immunity to SARS-CoV-2 mRNA vaccination has frequently been observed in individuals with various immunodeficiencies. Given the increased antibody evasion properties of emerging SARS-CoV-2 subvariants, it is necessary to assess whether other components of adaptive immunity generate resilient and protective responses against infection. We assessed T cell responses in 279 individuals, covering five different immunodeficiencies and healthy controls, before and after booster mRNA vaccination, as well as after Omicron infection in a subset of patients. We observed robust and persistent Omicron-reactive T cell responses that increased markedly upon booster vaccination and correlated directly with antibody titers across all patient groups. Poor vaccination responsiveness in immunocompromised or elderly individuals was effectively counteracted by the administration of additional vaccine doses. Functionally, Omicron-reactive T cell responses exhibited a pronounced cytotoxic profile and signs of longevity, characterized by CD45RA+ effector memory subpopulations with stem cell-like properties and increased proliferative capacity. Regardless of underlying immunodeficiency, booster-vaccinated and Omicron-infected individuals appeared protected against severe disease and exhibited enhanced and diversified T cell responses against conserved and Omicron-specific epitopes. Our findings indicate that T cells retain the ability to generate highly functional responses against newly emerging variants, even after repeated antigen exposure and a robust immunological imprint from ancestral SARS-CoV-2 mRNA vaccination.", "doi": "10.1126/scitranslmed.adg9452", "pmid": "37437015", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-07-13T11:33:29.721Z", "modified": "2023-10-04T13:10:33.441Z"}, {"entity": "publication", "iuid": "a76734b17d444d2197424cfb38e73d84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a76734b17d444d2197424cfb38e73d84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a76734b17d444d2197424cfb38e73d84"}}, "title": "A design strategy to generate a SARS-CoV-2 RBD vaccine that abrogates ACE2 binding and improves neutralizing antibody responses.", "authors": [{"family": "Ratswohl", "given": "Christoph", "initials": "C", "orcid": "0000-0001-5413-0730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3c10f6df613450abcf5f5bf55a7b781.json"}}, {"family": "V\u00e1zquez Garc\u00eda", "given": "Clara", "initials": "C", "orcid": "0000-0003-4583-7616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/622a5e04069f4e0baedf9c4a21fed629.json"}}, {"family": "Ahmad", "given": "Ata Ul Wakeel", "initials": "AUW", "orcid": "0009-0003-0734-7904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/699b0a9abd014f9b923b0fd1392c9fd2.json"}}, {"family": "Gonschior", "given": "Hannes", "initials": "H", "orcid": "0000-0002-1775-8120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c36380bcaae467aba65ee13d7b0ffac.json"}}, {"family": "Lebedin", "given": "Mikhail", "initials": "M", "orcid": "0000-0002-3877-7195", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c19b8f990f2415aa1646e45343d082d.json"}}, {"family": "Silvis", "given": "Casper Ewijn", "initials": "CE", "orcid": "0009-0005-0433-2197", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee84cb3452784753b662fae0c62e6879.json"}}, {"family": "Spatt", "given": "Lisa", "initials": "L"}, {"family": "Gerhard", "given": "Cathrin", "initials": "C"}, {"family": "Lehmann", "given": "Martin", "initials": "M", "orcid": "0000-0002-8370-6353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ed100612ee3422f97d023858f63405d.json"}}, {"family": "Sander", "given": "Leif E", "initials": "LE", "orcid": "0000-0002-0476-9947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36c4c59d112a4a2dbdc313dcd69c9702.json"}}, {"family": "Kurth", "given": "Florian", "initials": "F", "orcid": "0000-0002-3807-473X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32dfbcb28c674000bb43fefe2938c711.json"}}, {"family": "Olsson", "given": "Simon", "initials": "S", "orcid": "0000-0002-3927-7897", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b6b2b0004ffe46ef8ba4181876a55762.json"}}, {"family": "de la Rosa", "given": "Kathrin", "initials": "K", "orcid": "0000-0003-4809-3157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee415ff0f17846ed8a136217a243409a.json"}}], "type": "journal article", "published": "2023-07-12", "journal": {"title": "Eur J Immunol", "issn": "1521-4141", "issn-l": null, "volume": null, "issue": null, "pages": "e2350408"}, "abstract": "The structure-based design of antigens holds promise for developing vaccines with higher efficacy and improved safety profiles. We postulate that abrogation of host receptor interaction bears potential for the improvement of vaccines by preventing antigen-induced modification of receptor function as well as the displacement or masking of the immunogen. Antigen modifications may yet destroy epitopes crucial for antibody neutralization. Here, we present a methodology that integrates deep mutational scans to identify and score SARS-CoV-2 receptor binding domain variants that maintain immunogenicity, but lack interaction with the widely expressed host receptor. Single point mutations were scored in silico, validated in vitro, and applied in vivo. Our top-scoring variant receptor binding domain-G502E prevented spike-induced cell-to-cell fusion, receptor internalization, and improved neutralizing antibody responses by 3.3-fold in rabbit immunizations. We name our strategy BIBAX for body-inert, B-cell-activating vaccines, which in the future may be applied beyond SARS-CoV-2 for the improvement of vaccines by design.", "doi": "10.1002/eji.202350408", "pmid": "37435628", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:10:39.531Z", "modified": "2023-10-04T13:28:51.730Z"}, {"entity": "publication", "iuid": "0784cfd79da945169d97f806226c1339", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0784cfd79da945169d97f806226c1339.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0784cfd79da945169d97f806226c1339"}}, "title": "Results of the first nationwide cohort study of outcomes in dialysis and kidney transplant patients before and after vaccination for COVID-19.", "authors": [{"family": "Wijkstr\u00f6m", "given": "Julia", "initials": "J", "orcid": "0000-0001-6183-5878", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c90a939ef95648a5812cda3a5769ca78.json"}}, {"family": "Caldinelli", "given": "Aurora", "initials": "A"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A", "orcid": "0000-0002-9752-9941", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86a352b1ff85430daf1cebd1c210d38b.json"}}, {"family": "Nowak", "given": "Alexandra", "initials": "A"}, {"family": "Artborg", "given": "Angelica", "initials": "A"}, {"family": "Stendahl", "given": "Maria", "initials": "M"}, {"family": "Segelmark", "given": "M\u00e5rten", "initials": "M", "orcid": "0000-0002-1221-0772", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39ab2e6d40d441389c037b936eaac574.json"}}, {"family": "Lindholm", "given": "Bengt", "initials": "B"}, {"family": "Bellocco", "given": "Rino", "initials": "R"}, {"family": "Rydell", "given": "Helena", "initials": "H"}, {"family": "Evans", "given": "Marie", "initials": "M", "orcid": "0000-0001-8650-5795", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adad70f1421b4ae49c160017cfba58a1.json"}}], "type": "journal article", "published": "2023-07-11", "journal": {"title": "Nephrol Dial Transplant", "issn": "1460-2385", "issn-l": "0931-0509", "volume": null, "issue": null, "pages": null}, "abstract": "Patients with kidney replacement therapy (KRT) have been identified as a vulnerable group during the COVID-19 pandemic. This study reports the outcomes of COVID-19 in KRT patients in Sweden, a country where patients on KRT were prioritized early in the vaccination campaign.\r\n\r\nPatients with KRT between January 2019 and December 2021 in the Swedish Renal Registry were included. Data were linked to national healthcare registries. The primary outcome was monthly all-cause mortality over three-years follow-up. The secondary outcomes were monthly COVID-19 related deaths and hospitalizations. The results were compared with the general population using standardized mortality ratios. The difference in risk for COVID-19 related outcomes between dialysis and kidney transplant recipients was assessed in multivariable logistic regression models before and after vaccinations started.\r\n\r\nOn January 1, 2020, there were 4097 patients on dialysis (median age 70) and 5905 kidney transplant recipients (median age 58). Between March 2020 and February 2021, mean all-cause mortality rates increased by 10% (from 720 to 804 deaths) and 22% (from 158 to 206 deaths) in dialysis and kidney transplant recipients respectively compared with the same period 2019. After vaccinations started, all-cause mortality rates during the third wave (April 2021) returned to pre COVID-19 mortality rates among dialysis patients, while mortality rates remained increased among transplant recipients. Dialysis patients had a higher risk for COVID-19 hospitalizations and death before vaccinations started aOR 2.1 (95% CI 1.7-2.5), but a lower risk after vaccination, aOR 0.5 (95% CI 0.4-0.7) compared to kidney transplant recipients.\r\n\r\nThe COVID-19 pandemic in Sweden resulted in increased mortality and hospitalization rates among KRT patients. After vaccinations started, a distinct reduction in hospitalization and mortality rates was observed among dialysis patients, but not in kidney transplant recipients. Early and prioritized vaccinations of KRT patients in Sweden probably saved many lives.", "doi": "10.1093/ndt/gfad151", "pmid": "37433606", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "7222920"}], "notes": [], "created": "2023-10-04T12:08:47.555Z", "modified": "2023-10-04T12:40:55.746Z"}, {"entity": "publication", "iuid": "d70c893e2e234b7887b2b8d5b290ecd4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d70c893e2e234b7887b2b8d5b290ecd4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d70c893e2e234b7887b2b8d5b290ecd4"}}, "title": "Predictors of Sustained Physical Activity During the COVID-19 Pandemic in People With Parkinson Disease in Sweden.", "authors": [{"family": "Moulaee Conradsson", "given": "David", "initials": "D"}, {"family": "Leavy", "given": "Breiffni", "initials": "B"}, {"family": "Hagstr\u00f6mer", "given": "Maria", "initials": "M"}, {"family": "Franz\u00e9n", "given": "Erika", "initials": "E"}], "type": "journal article", "published": "2023-07-10", "journal": {"title": "J Neurol Phys Ther", "issn": "1557-0584", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "During the first wave of the COVID-19 pandemic, people with Parkinson disease (PwPD) reported deterioration in health and physical activity. The aim of this study was to describe 1-year changes in physical activity and perceived health in PwPD during the COVID-19 pandemic and to identify predictors of sustained physical activity.\r\n\r\nThis study compared perceived health and sensor-derived physical activity (Actigraph GT3x) in PwPD between the first (June to July 2020) and third waves (June to July 2021) of the pandemic. Multiple logistic regression analyses were used to predict sustained physical activity across the study period using personal factors, disease severity, and functioning as independent variables.\r\n\r\nSixty-three PwPD (mean age 71.0 years, 41% females) completed both baseline and 1-year follow-up (26 lost to follow-up). PwPD showed a decrease in average number of steps per day (\u0394415 steps, P = 0.048), moderate-to-vigorous-physical activity (\u03947 minutes, P = 0.007) and increase in sedentary time (\u039436 minutes, P <.001) between baseline and 1-year follow-up. While self-perceived walking impairments and depressive symptoms increased significantly, balance confidence decreased between baseline and 1-year follow-up, no significant changes occurred for self-rated health, quality of life, or anxiety. Significant predictors of sustained physical activity levels were 15 years or more of education (odds ratio [OR] = 7.38, P = 0.013) and higher perceived walking ability (OR = 0.18, P = 0.041).\r\n\r\nAmong PwPD with mild to moderate disease severity living in Sweden, factors associated with reduced physical activity levels during the COVID-19 pandemic included older age, lower education levels, and greater perceived walking difficulties.Video Abstract available for more insights from the authors (see the Video, the Supplemental Digital Content, available at: http://links.lww.com/JNPT/A451).", "doi": "10.1097/NPT.0000000000000455", "pmid": "37436217", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "01253086-990000000-00045"}], "notes": [], "created": "2023-10-04T12:09:30.076Z", "modified": "2023-10-04T12:54:56.989Z"}, {"entity": "publication", "iuid": "464dfd70bfc3466082fd3a71ab1be22c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/464dfd70bfc3466082fd3a71ab1be22c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/464dfd70bfc3466082fd3a71ab1be22c"}}, "title": "MEDIATE - Molecular DockIng at homE: Turning collaborative simulations into therapeutic solutions.", "authors": [{"family": "Vistoli", "given": "Giulio", "initials": "G"}, {"family": "Manelfi", "given": "Candida", "initials": "C"}, {"family": "Talarico", "given": "Carmine", "initials": "C"}, {"family": "Fava", "given": "Anna", "initials": "A"}, {"family": "Warshel", "given": "Arieh", "initials": "A"}, {"family": "Tetko", "given": "Igor V", "initials": "IV"}, {"family": "Apostolov", "given": "Rossen", "initials": "R"}, {"family": "Ye", "given": "Yang", "initials": "Y"}, {"family": "Latini", "given": "Chiara", "initials": "C"}, {"family": "Ficarelli", "given": "Federico", "initials": "F"}, {"family": "Palermo", "given": "Gianluca", "initials": "G", "orcid": "0000-0001-7955-8012", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c8395c9ce314613b2fca368fc49a2dd.json"}}, {"family": "Gadioli", "given": "Davide", "initials": "D"}, {"family": "Vitali", "given": "Emanuele", "initials": "E"}, {"family": "Varriale", "given": "Gaetano", "initials": "G"}, {"family": "Pisapia", "given": "Vincenzo", "initials": "V"}, {"family": "Scaturro", "given": "Marco", "initials": "M"}, {"family": "Coletti", "given": "Silvano", "initials": "S"}, {"family": "Gregori", "given": "Daniele", "initials": "D"}, {"family": "Gruffat", "given": "Daniel", "initials": "D"}, {"family": "Leija", "given": "Edgardo", "initials": "E"}, {"family": "Hessenauer", "given": "Sam", "initials": "S"}, {"family": "Delbianco", "given": "Alberto", "initials": "A"}, {"family": "Allegretti", "given": "Marcello", "initials": "M"}, {"family": "Beccari", "given": "Andrea R", "initials": "AR"}], "type": "journal article", "published": "2023-07-10", "journal": {"title": "Expert Opin Drug Discov", "issn": "1746-045X", "issn-l": null, "volume": "18", "issue": "8", "pages": "821-833"}, "abstract": "Collaborative computing has attracted great interest in the possibility of joining the efforts of researchers worldwide. Its relevance has further increased during the pandemic crisis since it allows for the strengthening of scientific collaborations while avoiding physical interactions. Thus, the E4C consortium presents the MEDIATE initiative which invited researchers to contribute via their virtual screening simulations that will be combined with AI-based consensus approaches to provide robust and method-independent predictions. The best compounds will be tested, and the biological results will be shared with the scientific community.\r\n\r\nIn this paper, the MEDIATE initiative is described. This shares compounds' libraries and protein structures prepared to perform standardized virtual screenings. Preliminary analyses are also reported which provide encouraging results emphasizing the MEDIATE initiative's capacity to identify active compounds.\r\n\r\nStructure-based virtual screening is well-suited for collaborative projects provided that the participating researchers work on the same input file. Until now, such a strategy was rarely pursued and most initiatives in the field were organized as challenges. The MEDIATE platform is focused on SARS-CoV-2 targets but can be seen as a prototype which can be utilized to perform collaborative virtual screening campaigns in any therapeutic field by sharing the appropriate input files.", "doi": "10.1080/17460441.2023.2221025", "pmid": "37424369", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null, "Funder: H2020": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:12:49.893Z", "modified": "2023-10-04T13:35:51.361Z"}, {"entity": "publication", "iuid": "c4c830abc4d14a30afe060376ff608dc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c4c830abc4d14a30afe060376ff608dc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c4c830abc4d14a30afe060376ff608dc"}}, "title": "COVID-19 risk perception and public compliance with preventive measures: Evidence from a multi-wave household survey in the MENA region.", "authors": [{"family": "Abu Hatab", "given": "Assem", "initials": "A", "orcid": "0000-0002-6764-1887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/555972d8e62042e19e254cc81a9f3743.json"}}, {"family": "Krautscheid", "given": "Lena", "initials": "L"}, {"family": "Amuakwa-Mensah", "given": "Franklin", "initials": "F", "orcid": "0000-0002-3581-4704", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cb40adcc28c419f99e56a827b03ef74.json"}}], "type": "journal article", "published": "2023-07-10", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "7", "pages": "e0283412"}, "abstract": "This study investigates the association between individuals' concern about contracting COVID-19 and their compliance with recommended preventive and mitigation measures, namely wearing face masks, maintaining social distancing and handwashing, in the context of the Middle East and North Africa (MENA) region. The empirical analysis is based on a panel dataset from the Combined COVID-19 MENA Monitor Household Survey, which was carried out in Jordan, Morocco, Sudan, Tunisia and Egypt. Applying a probit estimation technique, a positive and statistically significant association was found between the level of COVID-19 worries and individuals' compliance with the mitigation measures. Notably, the results revealed that this association followed a \"first-up-then-down\" trend, showing that compliance with the three mitigation measures rose as individuals' worries about contracting the virus increased, and then markedly decreased after they had been infected. Socio-demographic characteristics contributing to lower levels of compliance included being male, being over 60, having lower levels of education and having a lower household income. A cross-country analysis revealed remarkable differences between the five countries, with the strongest association between COVID-19 concerns and adherence to mitigation measures observed in Tunisia and Sudan, and the weakest association seen in Jordan and Morocco. Policy implications are outlined for effective risk communication and management during disease outbreaks and public health emergencies to encourage appropriate public health behaviours.", "doi": "10.1371/journal.pone.0283412", "pmid": "37428731", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10332611"}, {"db": "pii", "key": "PONE-D-22-31846"}], "notes": [], "created": "2023-10-04T12:08:50.332Z", "modified": "2023-10-04T12:42:27.896Z"}, {"entity": "publication", "iuid": "a7d0e355c176491a894c755145aea491", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7d0e355c176491a894c755145aea491.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7d0e355c176491a894c755145aea491"}}, "title": "Sociodemographic disparities affect COVID-19 vaccine uptake in non-elderly adults with increased risk of severe COVID-19.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P", "orcid": "0000-0003-3153-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd6af5accfc84ff9a81983a5ab6683aa.json"}}, {"family": "Sotoodeh", "given": "Adonis", "initials": "A"}, {"family": "Askling", "given": "Helena H", "initials": "HH"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P", "orcid": "0000-0002-8185-2648", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78b415aee4864810b8ce8f1962fa288f.json"}}], "type": "journal article", "published": "2023-07-09", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "There is limited information about sociodemographic disparities in COVID-19 vaccine uptake among non-elderly adults with an increased risk of severe COVID-19. We investigated the COVID-19 vaccine uptake in individuals aged 18-64 years with an increased risk of severe COVID-19 (non-elderly risk group) in Stockholm County, Sweden.\r\n\r\nWe used population-based health and sociodemographic registries with high coverage to perform a cohort study of COVID-19 vaccine uptake of one to four doses up until 21 November 2022. The vaccine uptake in the non-elderly risk group was compared with non-risk groups aged 18-64 years (non-elderly non-risk group) and individuals aged \u226565 years (elderly).\r\n\r\nThe uptake of \u22653 vaccine doses was 55%, 64% and 87% in the non-elderly non-risk group (n = 1,005,182), non-elderly risk group (n = 308,904) and elderly (n = 422,604), respectively. Among non-elderly risk group conditions, Down syndrome showed the strongest positive association with receiving three doses (adjusted risk ratio [aRR] 1.62, 95% confidence interval [CI] 1.54-1.71), whereas chronic liver disease showed the strongest negative association (aRR 0.90, 95% CI 0.88-0.92). Higher vaccine uptake among the non-elderly risk group was associated with increasing age, being born in Sweden, higher education, higher income and living in a household where other adults had been vaccinated. Similar trends were observed for the first, second, third and fourth doses.\r\n\r\nThese results call for measures to tackle sociodemographic disparities in vaccination programmes during and beyond the COVID-19 pandemic.", "doi": "10.1111/joim.13700", "pmid": "37424218", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Vaccines": null, "Category: Social Science & Humanities": null, "Funder: H2020": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:08:33.778Z", "modified": "2023-10-04T12:38:05.602Z"}, {"entity": "publication", "iuid": "6e47af3193934ba68696ee3e1a095195", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e47af3193934ba68696ee3e1a095195.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e47af3193934ba68696ee3e1a095195"}}, "title": "Diabetes status and other factors as correlates of risk for thrombotic and thromboembolic events during SARS-CoV-2 infection: A nationwide retrospective case-control study using Cerner Real-World Data\u2122.", "authors": [{"family": "Tallon", "given": "Erin M", "initials": "EM", "orcid": "0000-0003-1353-6632", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84a1b4722f504e2f8b66735df7ae7155.json"}}, {"family": "Gallagher", "given": "Mary Pat", "initials": "MP"}, {"family": "Staggs", "given": "Vincent S", "initials": "VS"}, {"family": "Ferro", "given": "Diana", "initials": "D"}, {"family": "Murthy", "given": "Deepa Badrinath", "initials": "DB"}, {"family": "Ebekozien", "given": "Osagie", "initials": "O"}, {"family": "Kosiborod", "given": "Mikhail N", "initials": "MN"}, {"family": "Lind", "given": "Marcus", "initials": "M"}, {"family": "Manrique-Acevedo", "given": "Camila", "initials": "C"}, {"family": "Shyu", "given": "Chi-Ren", "initials": "C"}, {"family": "Clements", "given": "Mark A", "initials": "MA"}], "type": "journal article", "published": "2023-07-09", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "7", "pages": "e071475"}, "abstract": "We sought to examine in individuals with SARS-CoV-2 infection whether risk for thrombotic and thromboembolic events (TTE) is modified by presence of a diabetes diagnosis. Furthermore, we analysed whether differential risk for TTEs exists in type 1 diabetes mellitus (T1DM) versus type 2 diabetes mellitus (T2DM).\r\n\r\nRetrospective case-control study.\r\n\r\nThe December 2020 version of the Cerner Real-World Data COVID-19 database is a deidentified, nationwide database containing electronic medical record (EMR) data from 87 US-based health systems.\r\n\r\nWe analysed EMR data for 322 482 patients >17 years old with suspected or confirmed SARS-CoV-2 infection who received care between December 2019 and mid-September 2020. Of these, 2750 had T1DM; 57 811 had T2DM; and 261 921 did not have diabetes.\r\n\r\nTTE, defined as presence of a diagnosis code for myocardial infarction, thrombotic stroke, pulmonary embolism, deep vein thrombosis or other TTE.\r\n\r\nOdds of TTE were substantially higher in patients with T1DM (adjusted OR (AOR) 2.23 (1.93-2.59)) and T2DM (AOR 1.52 (1.46-1.58)) versus no diabetes. Among patients with diabetes, odds of TTE were lower in T2DM versus T1DM (AOR 0.84 (0.72-0.98)).\r\n\r\nRisk of TTE during COVID-19 illness is substantially higher in patients with diabetes. Further, risk for TTEs is higher in those with T1DM versus T2DM. Confirmation of increased diabetes-associated clotting risk in future studies may warrant incorporation of diabetes status into SARS-CoV-2 infection treatment algorithms.", "doi": "10.1136/bmjopen-2022-071475", "pmid": "37423628", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10335498"}, {"db": "pii", "key": "bmjopen-2022-071475"}], "notes": [], "created": "2023-10-04T12:07:51.817Z", "modified": "2023-10-04T12:27:06.639Z"}, {"entity": "publication", "iuid": "3b0dc67557c1496d8ba7b7707a7eaab4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b0dc67557c1496d8ba7b7707a7eaab4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b0dc67557c1496d8ba7b7707a7eaab4"}}, "title": "Electronic Tongue for Direct Assessment of SARS-CoV-2-Free and Infected Human Saliva-A Feasibility Study.", "authors": [{"family": "Falk", "given": "Magnus", "initials": "M"}, {"family": "Psotta", "given": "Carolin", "initials": "C"}, {"family": "Cirovic", "given": "Stefan", "initials": "S"}, {"family": "Ohlsson", "given": "Lars", "initials": "L"}, {"family": "Shleev", "given": "Sergey", "initials": "S", "orcid": "0000-0001-6421-2158", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de6b1d4bf8f346d4baae7225d7d44876.json"}}], "type": "journal article", "published": "2023-07-07", "journal": {"title": "Biosensors (Basel)", "issn": "2079-6374", "issn-l": null, "volume": "13", "issue": "7", "pages": null}, "abstract": "An electronic tongue is a powerful analytical instrument based on an array of non-selective chemical sensors with a partial specificity for data gathering and advanced pattern recognition methods for data analysis. Connecting electronic tongues with electrochemical techniques for data collection has led to various applications, mostly within sensing for food quality and environmental monitoring, but also in biomedical research for the analyses of different bioanalytes in human physiological fluids. In this paper, an electronic tongue consisting of six electrodes (viz., gold, platinum, palladium, titanium, iridium, and glassy carbon) was designed and tested in authentic (undiluted, unpretreated) human saliva samples from eight volunteers, collected before and during the COVID-19 pandemic. Investigations of 11 samples using differential pulse voltammetry and a principal component analysis allowed us to distinguish between SARS-CoV-2-free and infected authentic human saliva. This work, as a proof-of-principle demonstration, provides a new perspective for the use of electronic tongues in the field of enzyme-free electrochemical biosensing, highlighting their potential for future applications in non-invasive biomedical analyses.", "doi": "10.3390/bios13070717", "pmid": "37504115", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10377364"}, {"db": "pii", "key": "bios13070717"}], "notes": [], "created": "2023-10-04T12:08:28.764Z", "modified": "2023-10-04T12:36:09.449Z"}, {"entity": "publication", "iuid": "f1a822b3d12043ea9b8edf0c56c1d403", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1a822b3d12043ea9b8edf0c56c1d403.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1a822b3d12043ea9b8edf0c56c1d403"}}, "title": "Characterising information loss due to aggregating epidemic model outputs", "authors": [{"family": "Sherratt", "given": "Katharine", "initials": "K", "orcid": "0000-0003-2049-3423", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2318c0e1d33c49bc8315d0b179581b11.json"}}, {"family": "Srivastava", "given": "Ajitesh", "initials": "A"}, {"family": "Ainslie", "given": "Kylie", "initials": "K", "orcid": "0000-0001-5419-7206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d900ed1096f431dbe5a2890503e2ae1.json"}}, {"family": "Singh", "given": "David E", "initials": "DE", "orcid": "0000-0002-8125-0049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f1646cc9a394508ba40e9fe2c2bb75e.json"}}, {"family": "Cublier", "given": "Aymar", "initials": "A"}, {"family": "Marinescu", "given": "Maria Cristina", "initials": "MC", "orcid": "0000-0002-6978-2974", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/afe31d3872854952b2a3f7725a21601b.json"}}, {"family": "Carretero", "given": "Jesus", "initials": "J"}, {"family": "Garcia", "given": "Alberto Cascajo", "initials": "AC", "orcid": "0000-0001-5506-1431", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72d4f2d2fe6c4bf09fd10748c7524706.json"}}, {"family": "Franco", "given": "Nicolas", "initials": "N"}, {"family": "Willem", "given": "Lander", "initials": "L", "orcid": "0000-0002-9210-1196", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/485594f08c334c55bcf8b1159db1befc.json"}}, {"family": "Abrams", "given": "Steven", "initials": "S", "orcid": "0000-0001-7353-9304", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c906aa35960e4612801d310cc7e44780.json"}}, {"family": "Faes", "given": "Christel", "initials": "C", "orcid": "0000-0002-1878-9869", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f126c26524e048eda78269dd8d36f6e9.json"}}, {"family": "Beutels", "given": "Philippe", "initials": "P", "orcid": "0000-0001-5034-3595", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1de885449fe44778dd1839a3737ac97.json"}}, {"family": "Hens", "given": "Niel", "initials": "N", "orcid": "0000-0003-1881-0637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72e67c1e6e6f4d3496183bfcd15c1a18.json"}}, {"family": "M\u00fcller", "given": "Sebastian", "initials": "S"}, {"family": "Charlton", "given": "Billy", "initials": "B", "orcid": "0000-0002-4760-996X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/17046ad3048f43fe9a462a56c9b0ad90.json"}}, {"family": "Ewert", "given": "Ricardo", "initials": "R", "orcid": "0000-0002-6973-3099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a979805944554162b50eb9e860600d56.json"}}, {"family": "Paltra", "given": "Sydney", "initials": "S", "orcid": "0000-0002-4935-8586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/781a2344678d4aed9d4b04b69bec979c.json"}}, {"family": "Rakow", "given": "Christian", "initials": "C", "orcid": "0000-0003-3760-2243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b209fde9192647fe81f8e6a169790bd6.json"}}, {"family": "Rehmann", "given": "Jakob", "initials": "J", "orcid": "0000-0002-1666-6419", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b69a6e1b3534dd3a45d3847e9f1d37b.json"}}, {"family": "Conrad", "given": "Tim", "initials": "T", "orcid": "0000-0002-5590-5726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1512820ad7794988966c276b7270b720.json"}}, {"family": "Sch\u00fctte", "given": "Christof", "initials": "C", "orcid": "0000-0001-5232-2683", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb4b8b18ea234b92b78364166afb1ace.json"}}, {"family": "Nagel", "given": "Kai", "initials": "K", "orcid": "0000-0003-2775-6898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a51017fbe39c432397d0b1dcd9ca69d4.json"}}, {"family": "Grah", "given": "Rok", "initials": "R", "orcid": "0000-0003-2539-3560", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/825d13bbd68a4e3483c5bf5dca6b6233.json"}}, {"family": "Niehus", "given": "Rene", "initials": "R", "orcid": "0000-0002-6751-4124", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92be39b444394d7a82b312737c389cc8.json"}}, {"family": "Prasse", "given": "Bastian", "initials": "B", "orcid": "0000-0002-7935-9109", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/108d55fb4f0b4dbf90a12486fb9fa7bf.json"}}, {"family": "Sandmann", "given": "Frank", "initials": "F", "orcid": "0000-0001-5641-1931", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d25db72e13d48238c49df02d06639b2.json"}}, {"family": "Funk", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-2842-3406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f03dcbc41884648a4eac5892852899a.json"}}], "type": "posted-content", "published": "2023-07-07", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.07.05.23292245", "pmid": null, "labels": {"Type: Preprint": null, "Category: Other": null, "Funder: H2020": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:12:46.584Z", "modified": "2023-10-04T13:35:01.081Z"}, {"entity": "publication", "iuid": "15d790dcf72a433a8f785f425901fed1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15d790dcf72a433a8f785f425901fed1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15d790dcf72a433a8f785f425901fed1"}}, "title": "Characterization of a fieldable process for airborne virus detection", "authors": [{"family": "Du", "given": "Huifeng", "initials": "H", "orcid": "0000-0001-6281-4120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/442acad1a604483aa208a36d5ad7717d.json"}}, {"family": "Bruno", "given": "Simone", "initials": "S", "orcid": "0000-0001-9235-8226", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ab2d583e3cd489888297e07e4d997a0.json"}}, {"family": "Overholt", "given": "Kalon J", "initials": "KJ", "orcid": "0000-0001-9127-9112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7896a963a1da4f259cea799965effb2d.json"}}, {"family": "Palacios", "given": "Sebastian", "initials": "S", "orcid": "0009-0004-5736-147X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b51d649f4924c27b696ae994f76a2ed.json"}}, {"family": "Huang", "given": "Hsin Ho", "initials": "HH"}, {"family": "Barajas", "given": "Carlos", "initials": "C"}, {"family": "Gross", "given": "Ben", "initials": "B"}, {"family": "Lee", "given": "Cindy", "initials": "C"}, {"family": "Evile", "given": "Haley K", "initials": "HK"}, {"family": "de Sousa", "given": "Nuno Rufino", "initials": "NR"}, {"family": "Rothfuchs", "given": "Antonio Gigliotti", "initials": "AG", "orcid": "0000-0001-6001-7240", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00102c49ae2d41828272e850cd551c9f.json"}}, {"family": "Vecchio", "given": "Domitilla Del", "initials": "DD", "orcid": "0000-0001-6472-8576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bad192b794b4e94842be0fbb06788a2.json"}}], "type": "posted-content", "published": "2023-07-06", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.07.03.23292170", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:09:24.813Z", "modified": "2023-10-04T12:52:32.022Z"}, {"entity": "publication", "iuid": "2d28b2c9c308489387829597ab87bf6c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d28b2c9c308489387829597ab87bf6c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d28b2c9c308489387829597ab87bf6c"}}, "title": "Rethinking Immunity: An Ethnography of Risk and Migration in Sweden.", "authors": [{"family": "Mirsalehi", "given": "Talieh", "initials": "T", "orcid": "0000-0003-2864-0280", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d3c5321697fd43039f99d63566bebe47.json"}}], "type": "journal article", "published": "2023-07-04", "journal": {"title": "Med Anthropol", "issn": "1545-5882", "issn-l": null, "volume": "42", "issue": "5", "pages": "493-505"}, "abstract": "I outline the interplay between biological and socio-cultural dimensions of immunity and risk in the context of migration from Afghanistan to Sweden during the COVID-19 pandemic. Documenting my interlocutors' responses to everyday situations, I explore the challenges they face in a new society. Their references to immunity reveal ideas about bodily and biological functions, as well as sociocultural aspects of risk and immunity as fluid concepts. Understanding how different groups manage risk, practice care, and perceive immunity requires attention to the circumstances that surround individual and communal experiences of care practices. I reveal their perceptions, hopes, concerns, and strategies for immunization against the real risks they encounter.", "doi": "10.1080/01459740.2023.2213389", "pmid": "37253110", "labels": {"Category: Social Science & Humanities": null, "Type: Other": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:11:31.458Z", "modified": "2023-10-04T07:14:11.996Z"}, {"entity": "publication", "iuid": "2e07c80ee4504031838349be1d2dd99f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e07c80ee4504031838349be1d2dd99f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e07c80ee4504031838349be1d2dd99f"}}, "title": "Limosilactobacillus reuteri DSM 17938 supplementation and SARS-CoV-2 specific antibody response in healthy adults: a randomized, triple-blinded, placebo-controlled trial.", "authors": [{"family": "Forsg\u00e5rd", "given": "Richard A", "initials": "RA", "orcid": "0000-0002-1905-918X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d1d3d507a034502bec7777d404a9686.json"}}, {"family": "Rode", "given": "Julia", "initials": "J", "orcid": "0000-0001-9402-4756", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77722adb4fff41bebf126c2854614bc8.json"}}, {"family": "Lobenius-Palm\u00e9r", "given": "Karin", "initials": "K", "orcid": "0000-0001-6061-4643", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4cb5a2abe4b5407997d4a2f965091f1b.json"}}, {"family": "Kamm", "given": "Annalena", "initials": "A"}, {"family": "Patil", "given": "Snehal", "initials": "S"}, {"family": "Tacken", "given": "Mirriam G J", "initials": "MGJ"}, {"family": "Lentjes", "given": "Marleen A H", "initials": "MAH", "orcid": "0000-0003-4713-907X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6930e85465646889cd093e3490ed91c.json"}}, {"family": "Axelsson", "given": "Jakob", "initials": "J", "orcid": "0000-0003-4146-8374", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07b58911256b4da4b9fce60d9e364777.json"}}, {"family": "Grompone", "given": "Gianfranco", "initials": "G"}, {"family": "Montgomery", "given": "Scott", "initials": "S"}, {"family": "Brummer", "given": "Robert J", "initials": "RJ", "orcid": "0000-0002-0362-0008", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/320dbc6671aa4870b0e498001e756c01.json"}}], "type": "randomized controlled trial", "published": "2023-07-04", "journal": {"title": "Gut Microbes", "issn": "1949-0984", "issn-l": null, "volume": "15", "issue": "1", "pages": "2229938"}, "abstract": "Studies have shown that probiotics can decrease the symptoms of respiratory tract infections as well as increase antibody responses following certain vaccinations. We examined the effect of probiotic supplementation on anti-SARS-CoV-2 specific antibody responses upon SARS-CoV-2 infection as well as after COVID-19 vaccination. In this randomized, triple-blinded, placebo-controlled intervention study with a parallel design, 159 healthy adults without prior SARS-CoV-2 infection or COVID-19 vaccination and any known risk factors for severe COVID-19 were randomly allocated into two study arms. The active treatment arm consumed a probiotic product containing a minimum of 1 \u00d7 108 colony-forming units of Limosilactobacillus reuteri DSM 17938 + 10 \u03bcg vitamin D3 twice daily for 6 months. The placebo arm consumed identical tablets containing only 10 \u03bcg vitamin D3. Anti-SARS-CoV-2 specific antibodies and virus neutralizing antibody titers were analyzed from blood samples collected at baseline, after 3 months, and after 6 months. Differences in serum antibody titers between the two study arms were tested with independent t-test using log-transformed values. In the intention-to-treat (ITT) analysis, SARS-CoV-2 infected individuals in the active treatment arm (n = 6) tended to have higher serum anti-spike IgG (609 [168-1480] BAU/ml vs 111 [36.1-1210] BAU/ml, p = 0.080) and anti-receptor binding domain (RBD) IgG (928 [212-3449] BAU/ml vs (83.7 [22.8-2094] BAU/ml, p = 0.066) levels than individuals in the placebo arm (n = 6). Considering individuals who were fully vaccinated with mRNA-based COVID-19 vaccines, the active treatment arm (n = 10) exhibited significantly higher serum levels of anti-RBD IgA (135 [32.9-976] BAU/ml vs 61.3 [26.7-97.1] BAU/ml, p = 0.036) than the placebo arm (n = 7) >28 days postvaccination. Supplementation with specific probiotics might improve the long-term efficacy of mRNA-based COVID-19 vaccines via enhanced IgA response.", "doi": "10.1080/19490976.2023.2229938", "pmid": "37401761", "labels": {"Category: Other": null, "Category: Vaccines": null, "Funder: H2020": null}, "xrefs": [{"db": "pmc", "key": "PMC10321188"}], "notes": [], "created": "2023-10-04T12:07:54.497Z", "modified": "2023-10-04T12:28:27.762Z"}, {"entity": "publication", "iuid": "6a8e0b3a19ee4b38b0a41b24e28e3a03", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a8e0b3a19ee4b38b0a41b24e28e3a03.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a8e0b3a19ee4b38b0a41b24e28e3a03"}}, "title": "Policies and resources for strengthening of emergency and critical care services in the context of the global COVID-19 pandemic in Kenya.", "authors": [{"family": "Oliwa", "given": "Jacquie Narotso", "initials": "JN", "orcid": "0000-0002-4575-2447", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9eae04e0d0fe47fc9263e1014a63a88d.json"}}, {"family": "Mazhar", "given": "Rosanna Jeffries", "initials": "RJ", "orcid": "0000-0003-2367-2072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/acca58542d9a49088ecbddbf9e0c4c99.json"}}, {"family": "Serem", "given": "George", "initials": "G"}, {"family": "Khalid", "given": "Karima", "initials": "K"}, {"family": "Amoth", "given": "Patrick", "initials": "P"}, {"family": "Kiarie", "given": "Helen", "initials": "H", "orcid": "0000-0003-2048-8173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b6b816132dba47889ba7e551e83d4fcf.json"}}, {"family": "Warfa", "given": "Osman", "initials": "O"}, {"family": "Schell", "given": "Carl Otto", "initials": "CO", "orcid": "0000-0002-7904-1336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a40b337b45b471d97a102c355c9d874.json"}}, {"family": "Baker", "given": "Tim", "initials": "T", "orcid": "0000-0001-8727-7018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1454fc20049b4d47865268adf16d104a.json"}}, {"family": "English", "given": "Mike", "initials": "M", "orcid": "0000-0002-7427-0826", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d680cdafc8854a619f1919652dd16aed.json"}}, {"family": "Mcknight", "given": "Jacob", "initials": "J"}], "type": "journal article", "published": "2023-07-03", "journal": {"title": "PLOS Glob Public Health", "issn": "2767-3375", "issn-l": null, "volume": "3", "issue": "7", "pages": "e0000483"}, "abstract": "Critical illnesses cause several million deaths annually, with many of these occurring in low-resource settings like Kenya. Great efforts have been made worldwide to scale up critical care to reduce deaths from COVID-19. Lower income countries with fragile health systems may not have had sufficient resources to upscale their critical care. We aimed to review how efforts to strengthen emergency and critical care were operationalised during the pandemic in Kenya to point towards how future emergencies should be approached. This was an exploratory study that involved document reviews, and discussions with key stakeholders (donors, international agencies, professional associations, government actors), during the first year of the pandemic in Kenya. Our findings suggest that pre-pandemic health services for the critically ill in Kenya were sparse and unable to meet rising demand, with major limitations noted in human resources and infrastructure. The pandemic response saw galvanised action by the Government of Kenya and other agencies to mobilise resources (approximately USD 218 million). Earlier efforts were largely directed towards advanced critical care but since the human resource gap could not be reduced immediately, a lot of equipment remained unused. We also note that despite strong policies on what resources should be available, the reality on the ground was that there were often critical shortages. While emergency response mechanisms are not conducive to addressing long-term health system issues, the pandemic increased global recognition of the need to fund care for the critically ill. Limited resources may be best prioritised towards a public health approach with focus on provision of relatively basic, lower cost essential emergency and critical care (EECC) that can potentially save the most lives amongst critically ill patients.", "doi": "10.1371/journal.pgph.0000483", "pmid": "37399177", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10317215"}, {"db": "pii", "key": "PGPH-D-22-00633"}], "notes": [], "created": "2023-10-04T12:10:47.776Z", "modified": "2023-10-04T13:31:35.356Z"}, {"entity": "publication", "iuid": "ad853f575d43489183421c0102c22497", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ad853f575d43489183421c0102c22497.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ad853f575d43489183421c0102c22497"}}, "title": "Relationship between People's Interest in Medication Adherence, Health Literacy, and Self-Care: An Infodemiological Analysis in the Pre- and Post-COVID-19 Era.", "authors": [{"family": "Grandieri", "given": "Andrea", "initials": "A", "orcid": "0000-0003-0553-5971", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e8a8fbb98fa4b2fbbb37e729c9276aa.json"}}, {"family": "Trevisan", "given": "Caterina", "initials": "C"}, {"family": "Gentili", "given": "Susanna", "initials": "S"}, {"family": "Vetrano", "given": "Davide Liborio", "initials": "DL", "orcid": "0000-0002-3099-4830", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0124721bb214413a34c965b6accc64b.json"}}, {"family": "Liotta", "given": "Giuseppe", "initials": "G"}, {"family": "Volpato", "given": "Stefano", "initials": "S"}], "type": "journal article", "published": "2023-07-01", "journal": {"title": "J Pers Med", "issn": "2075-4426", "issn-l": null, "volume": "13", "issue": "7", "pages": null}, "abstract": "The prevalence of non-communicable diseases has risen sharply in recent years, particularly among older individuals who require complex drug regimens. Patients are increasingly required to manage their health through medication adherence and self-care, but about 50% of patients struggle to adhere to prescribed treatments. This study explored the relationship between interest in medication adherence, health literacy, and self-care and how it changed during the COVID-19 pandemic. We used Google Trends to measure relative search volumes (RSVs) for these three topics from 2012 to 2022. We found that interest in self-care increased the most over time, followed by health literacy and medication adherence. Direct correlations emerged between RSVs for medication adherence and health literacy (r = 0.674, p < 0.0001), medication adherence and self-care (r = 0.466, p < 0.0001), and health literacy and self-care (r = 0.545, p < 0.0001). After the COVID-19 pandemic outbreak, interest in self-care significantly increased, and Latin countries showed a greater interest in self-care than other geographical areas. This study suggests that people are increasingly interested in managing their health, especially in the context of the recent pandemic, and that infodemiology may provide interesting information about the attitudes of the population toward chronic disease management.", "doi": "10.3390/jpm13071090", "pmid": "37511703", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10381156"}, {"db": "pii", "key": "jpm13071090"}], "notes": [], "created": "2023-10-04T12:09:58.719Z", "modified": "2023-10-04T13:06:56.219Z"}, {"entity": "publication", "iuid": "f8e34c2bbc934c90b3e24f59dbffe111", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f8e34c2bbc934c90b3e24f59dbffe111.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f8e34c2bbc934c90b3e24f59dbffe111"}}, "title": "Preclinical and Human Phase 1 Studies of Aerosolized Hydroxychloroquine: Implications for Antiviral COVID-19 Therapy", "authors": [{"family": "Bentur", "given": "Ohad S", "initials": "OS", "orcid": "0000-0002-5976-7121", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30bdc9224fad462196908646f277a76f.json"}}, {"family": "Hutt", "given": "Richard", "initials": "R"}, {"family": "Brassil", "given": "Donna", "initials": "D"}, {"family": "Kriegegr", "given": "Ana C", "initials": "AC"}, {"family": "B\u00e4ckman", "given": "Per", "initials": "P"}, {"family": "Charous", "given": "B Lauren", "initials": "BL"}, {"family": "Boushey", "given": "Homer", "initials": "H", "orcid": "0000-0002-4373-9265", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e67d654785c2406fb0ce1ba5f3d384a3.json"}}, {"family": "Gonda", "given": "Igor", "initials": "I"}, {"family": "Coller", "given": "Barry S", "initials": "BS", "orcid": "0000-0002-9078-7155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/648db6fb396f49938d98dcdc82b63658.json"}}, {"family": "MacArthur", "given": "Robert B", "initials": "RB", "orcid": "0000-0002-3264-4666", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a38b7120c21a4985be747fc84e7d9bd0.json"}}], "type": "posted-content", "published": "2023-07-01", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.06.22.23291702", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:07:45.920Z", "modified": "2023-10-04T12:24:46.443Z"}, {"entity": "publication", "iuid": "2090449e3a554ddc86000f62047f458c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2090449e3a554ddc86000f62047f458c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2090449e3a554ddc86000f62047f458c"}}, "title": "Use of the neutrophil-to-lymphocyte ratio and an oxygen requirement to predict disease severity in patients with COVID-19.", "authors": [{"family": "Ozawa", "given": "Takuya", "initials": "T"}, {"family": "Asakura", "given": "Takanori", "initials": "T"}, {"family": "Chubachi", "given": "Shotaro", "initials": "S"}, {"family": "Namkoong", "given": "Ho", "initials": "H"}, {"family": "Tanaka", "given": "Hiromu", "initials": "H"}, {"family": "Lee", "given": "Ko", "initials": "K"}, {"family": "Fukushima", "given": "Takahiro", "initials": "T"}, {"family": "Otake", "given": "Shiro", "initials": "S"}, {"family": "Nakagawara", "given": "Kensuke", "initials": "K"}, {"family": "Watase", "given": "Mayuko", "initials": "M"}, {"family": "Masaki", "given": "Katsunori", "initials": "K"}, {"family": "Kamata", "given": "Hirofumi", "initials": "H"}, {"family": "Ishii", "given": "Makoto", "initials": "M"}, {"family": "Hasegawa", "given": "Naoki", "initials": "N"}, {"family": "Harada", "given": "Norihiro", "initials": "N"}, {"family": "Ueda", "given": "Tetsuya", "initials": "T"}, {"family": "Ueda", "given": "Soichiro", "initials": "S"}, {"family": "Ishiguro", "given": "Takashi", "initials": "T"}, {"family": "Arimura", "given": "Ken", "initials": "K"}, {"family": "Saito", "given": "Fukuki", "initials": "F"}, {"family": "Yoshiyama", "given": "Takashi", "initials": "T"}, {"family": "Nakano", "given": "Yasushi", "initials": "Y"}, {"family": "Mutoh", "given": "Yoshikazu", "initials": "Y"}, {"family": "Suzuki", "given": "Yusuke", "initials": "Y"}, {"family": "Edahiro", "given": "Ryuya", "initials": "R"}, {"family": "Murakami", "given": "Koji", "initials": "K"}, {"family": "Okada", "given": "Yukinori", "initials": "Y"}, {"family": "Koike", "given": "Ryuji", "initials": "R"}, {"family": "Kitagawa", "given": "Yuko", "initials": "Y"}, {"family": "Tokunaga", "given": "Katsushi", "initials": "K"}, {"family": "Kimura", "given": "Akinori", "initials": "A"}, {"family": "Imoto", "given": "Seiya", "initials": "S"}, {"family": "Miyano", "given": "Satoru", "initials": "S"}, {"family": "Ogawa", "given": "Seishi", "initials": "S"}, {"family": "Kanai", "given": "Takanori", "initials": "T"}, {"family": "Fukunaga", "given": "Koichi", "initials": "K"}, {"family": "Japan COVID-19 Task Force", "given": "", "initials": ""}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Respir Investig", "issn": "2212-5353", "issn-l": null, "volume": "61", "issue": "4", "pages": "454-459"}, "abstract": "We investigated the association between complete blood count, including neutrophil-to-lymphocyte ratio (NLR) in combination with patient characteristics, and coronavirus disease (COVID-19) outcomes to identify the best prognostic indicator. We analyzed data of patients with confirmed COVID-19 from the nationwide database of the Japan COVID-19 Task Force between February 2020 and November 2021. A composite outcome was defined as the most severe condition, including noninvasive positive-pressure ventilation, high-flow nasal cannula, invasive mechanical ventilation, extracorporeal membrane oxygenation, or death. Of 2425 patients in the analysis, 472 (19.5%) experienced a composite outcome. NLR was the best predictor of composite outcomes, with an area under the curve (AUC) of 0.81, and a sensitivity and specificity of 72.3% and 75.7%, respectively, using a cut-off value of 5.04. The combination of NLR and an oxygen requirement on admission had the highest AUC (0.88). This simple combination may help identify patients at risk of progression to severe disease.", "doi": "10.1016/j.resinv.2023.03.007", "pmid": "37121116", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Category: Serology": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10113601"}, {"db": "pii", "key": "S2212-5345(23)00037-0"}], "notes": [], "created": "2023-10-04T05:11:33.967Z", "modified": "2023-10-04T07:15:20.168Z"}, {"entity": "publication", "iuid": "bede0574495043b5a03b3f9b2178cfea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bede0574495043b5a03b3f9b2178cfea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bede0574495043b5a03b3f9b2178cfea"}}, "title": "The association between leisure engagement and loneliness before and during the COVID-19 pandemic: A Nordic population-based study.", "authors": [{"family": "Nyqvist", "given": "Fredrica", "initials": "F", "orcid": "0000-0001-6554-8040", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc9027ea4dc241a18acd24a108cf33ce.json"}}, {"family": "Nilsson", "given": "Ingeborg", "initials": "I"}, {"family": "N\u00e4sman", "given": "Marina", "initials": "M"}, {"family": "Olofsson", "given": "Birgitta", "initials": "B"}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": "51", "issue": "5", "pages": "744-753"}, "abstract": "The main aim of this study was to examine leisure engagement and loneliness among older adults before and during the COVID-19 pandemic by analysing population-based data from western Finland and northern Sweden.\r\n\r\nThe data originated from the Gerontological Regional Database (GERDA) postal questionnaire study conducted in 2016 (n=7996) and 2021 (n=8148) among older adults aged 65, 70, 75, 80 and 85 years. Associations between loneliness and leisure engagement were analysed using logistic regression.\r\n\r\nIn total, 10% and 9% of the older adults reported loneliness in 2016 and 2021, respectively. The results showed that a lack of engagement in socialising and pleasure was independently associated with loneliness in both study years, while a lack of engagement in cultural activities was associated with loneliness in 2016 only. In 2021, the likelihood of experiencing loneliness was higher in the Finnish region than in the Swedish region. In addition, those reporting a decrease in hobby and socialising leisure activities due to the COVID-19 pandemic were more likely to report loneliness.\r\n\r\nMost leisure activities decreased during the pandemic, suggesting an increase in social isolation. However, this did not reflect an increase in loneliness in the studied regions. The evidence suggests that leisure engagement, especially socialising activities, continued to be important for well-being among older adults during the pandemic. Further, loneliness was affected by contextual factors as well as individual-level characteristics. Thus, according to the measures reported here, the pandemic seemed to have a slightly weakened well-being impact in Finland.", "doi": "10.1177/14034948231171964", "pmid": "37165572", "labels": {"Category: Social Science & Humanities": null, "Funder: VR": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10183342"}], "notes": [], "created": "2023-10-04T05:11:21.823Z", "modified": "2023-10-04T07:10:17.734Z"}, {"entity": "publication", "iuid": "770c1621ca0a42a8a46ddebe70cb92e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/770c1621ca0a42a8a46ddebe70cb92e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/770c1621ca0a42a8a46ddebe70cb92e1"}}, "title": "Taking Risks to Protect Others-Pediatric Vaccination and Moral Responsibility.", "authors": [{"family": "Nihl\u00e9n Fahlquist", "given": "Jessica", "initials": "J", "orcid": "0000-0001-9683-7005", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/927d3a3a934a45dca7f88072507aa153.json"}}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Public Health Ethics", "issn": "1754-9973", "issn-l": null, "volume": "16", "issue": "2", "pages": "127-138"}, "abstract": "The COVID-19 pandemic during 2020-2022 raised ethical questions concerning the balance between individual autonomy and the protection of the population, vulnerable individuals and the healthcare system. Pediatric COVID-19 vaccination differs from, for example, measles vaccination in that children were not as severely affected. The main question concerning pediatric vaccination has been whether the autonomy of parents outweighs the protection of the population. When children are seen as mature enough to be granted autonomy, questions arise about whether they have the right to decline vaccination and who should make the decision when parents disagree with each other and/or the child. In this paper, I argue that children should be encouraged to not only take responsibility for themselves, but for others. The discussion of pediatric vaccination in cases where this kind of risk-benefit ratio exists extends beyond the 2020-2022 pandemic. The pandemic entailed a question that is crucial for the future of public health as a global problem, that is, to what extent children should be seen as responsible decision-makers who are capable of contributing to its management and potential solution. I conclude that society should encourage children to cultivate such responsibility, conceived as a virtue, in the context of public health.", "doi": "10.1093/phe/phad005", "pmid": "37547911", "labels": {"Category: Public Health": null, "Type: Other": null, "Category: Vaccines": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10401494"}, {"db": "pii", "key": "phad005"}], "notes": [], "created": "2023-10-05T08:26:21.511Z", "modified": "2023-10-06T04:56:09.662Z"}, {"entity": "publication", "iuid": "07fa0b12e97341debcc3e6aab2a33c15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07fa0b12e97341debcc3e6aab2a33c15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07fa0b12e97341debcc3e6aab2a33c15"}}, "title": "Prognostic potential of creatinine and Cystatin C in COVID-19 - a retrospective cohort study from Karolinska University Hospital.", "authors": [{"family": "Sj\u00f6str\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Markgren", "given": "Per Olof", "initials": "PO"}, {"family": "Hansson", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Scand J Clin Lab Invest", "issn": "1502-7686", "issn-l": null, "volume": "83", "issue": "4", "pages": "251-257"}, "abstract": "Acute kidney injury (AKI) is common in COVID-19 and is diagnosed using relative serum creatinine increase. Estimated GFR (eGFR) is a more accurate measure of glomerular filtration due to compensation for age and sex. Serum Cystatin-C, less affected by non-renal factors than creatinine, may further improve renal function estimation and add prognostic information. Our aim is to investigate the importance of a calculated eGFR in relation to creatinine as well as the value of Cystatin-C in patients with severe COVID-19. This study is a retrospective cohort study investigating levels and trends of routine laboratory parameters combined with clinical data from 286 consecutive patients with severe COVID-19 from Karolinska University Hospital. AKI developed in 38% of the patients and 15% were treated with hemodialysis. Mortality in the AKI group was 42% compared to 5% in the non-AKI group. At admission, eGFR, but not creatinine, was significantly associated with AKI development, need of intubation and mortality. Moreover, discrepant results between eGFR creatinine (eGFRCR) and eGFR Cystatin-C (eGFRCYS) was common in the ICU patients compared to non-ICU patients and related to outcome. In addition, we found that daily median Cystatin-C levels during the hospital stay were correlated to neutrophil count. eGFRCR was found to be an overall better prognostic marker than creatinine regarding AKI development and prognosis in severe COVID-19. Fulfillment of Shrunken pore syndrome criteria indicated a higher mortality risk. Cystatin-C may be related to neutrophil count, which could be a clue to the discrepant eGFR results.", "doi": "10.1080/00365513.2023.2210291", "pmid": "37167478", "labels": {"Category: Proteins": null, "Category: Serology": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:10:12.197Z", "modified": "2023-10-04T06:28:40.854Z"}, {"entity": "publication", "iuid": "6acd649d6131409fba5f319ad7ac1f48", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6acd649d6131409fba5f319ad7ac1f48.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6acd649d6131409fba5f319ad7ac1f48"}}, "title": "Prognostic performance of blood neurofilament light chain protein in hospitalized COVID-19 patients without major central nervous system manifestations: an individual participant data meta-analysis.", "authors": [{"family": "Abdelhak", "given": "Ahmed", "initials": "A", "orcid": "0000-0001-9731-4169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2c3007e2b3e4af0855c4f64b89a1f69.json"}}, {"family": "Barba", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-4237-6850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0cec76ce00c94352aac33ccbf3a5028d.json"}}, {"family": "Romoli", "given": "Michele", "initials": "M", "orcid": "0000-0001-8009-8543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/954e16c7c9934d23b7b8a489adccf2d4.json"}}, {"family": "Benkert", "given": "Pascal", "initials": "P", "orcid": "0000-0001-6525-8174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a8e93f751ae40cbadbd19d8840639fe.json"}}, {"family": "Conversi", "given": "Francesco", "initials": "F"}, {"family": "D'Anna", "given": "Lucio", "initials": "L", "orcid": "0000-0002-6794-3850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1601767932dc4a4d9a8d0b5113763600.json"}}, {"family": "Masvekar", "given": "Ruturaj R", "initials": "RR", "orcid": "0000-0002-4570-4533", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25270f2a54cf416b9dde587dab0ade04.json"}}, {"family": "Bielekova", "given": "Bibiana", "initials": "B", "orcid": "0000-0002-0959-9430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b2a7812ae084c4b8b8f69168032e0b1.json"}}, {"family": "Prudencio", "given": "Mercedes", "initials": "M", "orcid": "0000-0002-4894-4858", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6206178f7b0448ffb963acacf6e37023.json"}}, {"family": "Petrucelli", "given": "Leonard", "initials": "L", "orcid": "0000-0003-2959-129X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46d6fe83e1494ae6be0214bd3b41e4ef.json"}}, {"family": "Meschia", "given": "James F", "initials": "JF", "orcid": "0000-0002-4475-8142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/590bd75802c640a0949896e6aa8befc8.json"}}, {"family": "Erben", "given": "Young", "initials": "Y", "orcid": "0000-0002-1571-6955", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b026b60bc68648579b7e0370ff00c0fe.json"}}, {"family": "Furlan", "given": "Roberto", "initials": "R", "orcid": "0000-0001-7376-9425", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/940db6ecfcbd4383a1369393fa8e206e.json"}}, {"family": "De Lorenzo", "given": "Rebecca", "initials": "R", "orcid": "0000-0002-1281-7996", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1eddd82f29f64c889211037bb64cf707.json"}}, {"family": "Mandelli", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-6494-7776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4d010bf83e14566bceae44bcd63d36c.json"}}, {"family": "Sutter", "given": "Raoul", "initials": "R", "orcid": "0000-0002-6575-356X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0a395e40bd6464084ec2cddd90f2295.json"}}, {"family": "Hert", "given": "Lisa", "initials": "L"}, {"family": "Epple", "given": "Varenka", "initials": "V", "orcid": "0000-0002-8736-0070", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7773c7cf8f4541019af057e2bbbdeefa.json"}}, {"family": "Marastoni", "given": "Damiano", "initials": "D", "orcid": "0000-0003-0358-9431", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af2ff46eb01a473aa077029d582903b2.json"}}, {"family": "Sellner", "given": "Johann", "initials": "J", "orcid": "0000-0001-8749-5533", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/38b82ef4d31a4939be4e1024faa664bb.json"}}, {"family": "Steinacker", "given": "Petra", "initials": "P"}, {"family": "Aamodt", "given": "Anne Hege", "initials": "AH", "orcid": "0000-0002-2824-2760", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b21211bae394fef867be93f162d8ef8.json"}}, {"family": "Heggelund", "given": "Lars", "initials": "L", "orcid": "0000-0002-1669-1032", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9befa124c647487d803e8dba68495821.json"}}, {"family": "Dyrhol-Riise", "given": "Anne Margarita", "initials": "AM", "orcid": "0000-0003-4009-4032", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/051b91855a064394a525b898992aa834.json"}}, {"family": "Virhammar", "given": "Johan", "initials": "J", "orcid": "0000-0001-9901-2949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9db4ac69a3e8495ea8e71ae60042fa5c.json"}}, {"family": "F\u00e4llmar", "given": "David", "initials": "D", "orcid": "0000-0001-5615-2036", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08e1206ab94a43788a7fc641ee13407c.json"}}, {"family": "Rostami", "given": "Elham", "initials": "E", "orcid": "0000-0003-1218-6247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c95efe7a4cc4fcfa73fac8b49641ca1.json"}}, {"family": "Kumlien", "given": "Eva", "initials": "E", "orcid": "0000-0002-1952-8791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de1d39588b21438fabae7d27acf4b237.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/351fab09f6e24b9f9e6695da83947cb6.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e314740b02c344d2b336a9410e28041e.json"}}, {"family": "Tumani", "given": "Hayrettin", "initials": "H", "orcid": "0000-0002-1647-6201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c76797ddf9d4909a1c5f2140ec3531e.json"}}, {"family": "Sacco", "given": "Simona", "initials": "S", "orcid": "0000-0003-0651-1939", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0447acf2277a43049232a0ad7614d310.json"}}, {"family": "Green", "given": "Ari J", "initials": "AJ", "orcid": "0000-0001-9275-3066", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/829f4905eef64f6b980141ae7b2e6f9b.json"}}, {"family": "Otto", "given": "Markus", "initials": "M", "orcid": "0000-0003-4273-4267", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e472a52c9d04a9fa4161d80fa0c6bdb.json"}}, {"family": "Kuhle", "given": "Jens", "initials": "J", "orcid": "0000-0002-6963-8892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/187936aaf8c342e58dec7adc5b23ad91.json"}}, {"family": "Ornello", "given": "Raffaele", "initials": "R", "orcid": "0000-0001-9501-4031", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/133160eee8a942dd9f7d6cad321520c6.json"}}, {"family": "Foschi", "given": "Matteo", "initials": "M", "orcid": "0000-0002-0321-7155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc49b113289e4deabff8a47fdf0bea6d.json"}}, {"family": "Abu-Rumeileh", "given": "Samir", "initials": "S", "orcid": "0000-0003-0631-8506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8531166b14e04d998571b80fb0e761ff.json"}}], "type": "meta-analysis", "published": "2023-07-00", "journal": {"title": "J Neurol", "issn": "1432-1459", "issn-l": null, "volume": "270", "issue": "7", "pages": "3315-3328"}, "abstract": "To investigate the prognostic value of blood neurofilament light chain protein (NfL) levels in the acute phase of coronavirus disease 2019 (COVID-19).\r\n\r\nWe conducted an individual participant data (IPD) meta-analysis after screening on MEDLINE and Scopus to May 23rd 2022. We included studies with hospitalized adult COVID-19 patients without major COVID-19-associated central nervous system (CNS) manifestations and with a measurement of blood NfL in the acute phase as well as data regarding at least one clinical outcome including intensive care unit (ICU) admission, need of mechanical ventilation (MV) and death. We derived the age-adjusted measures NfL Z scores and conducted mixed-effects modelling to test associations between NfL Z scores and other variables, encompassing clinical outcomes. Summary receiver operating characteristic curves (SROCs) were used to calculate the area under the curve (AUC) for blood NfL.\r\n\r\nWe identified 382 records, of which 7 studies were included with a total of 669 hospitalized COVID-19 cases (mean age 66.2 \u00b1 15.0 years, 68.1% males). Median NfL Z score at admission was elevated compared to the age-corrected reference population (2.37, IQR: 1.13-3.06, referring to 99th percentile in healthy controls). NfL Z scores were significantly associated with disease duration and severity. Higher NfL Z scores were associated with a higher likelihood of ICU admission, need of MV, and death. SROCs revealed AUCs of 0.74, 0.80 and 0.71 for mortality, need of MV and ICU admission, respectively.\r\n\r\nBlood NfL levels were elevated in the acute phase of COVID-19 patients without major CNS manifestations and associated with clinical severity and poor outcome. The marker might ameliorate the performance of prognostic multivariable algorithms in COVID-19.", "doi": "10.1007/s00415-023-11768-1", "pmid": "37184659", "labels": {"Category: Health": null, "Category: Proteins": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10183689"}, {"db": "pii", "key": "10.1007/s00415-023-11768-1"}], "notes": [], "created": "2023-10-04T05:10:19.728Z", "modified": "2023-10-04T06:35:13.442Z"}, {"entity": "publication", "iuid": "25d376987001470aa29efeaa325aa75e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/25d376987001470aa29efeaa325aa75e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/25d376987001470aa29efeaa325aa75e"}}, "title": "New evidence of gender inequality during COVID-19 outbreak in the Middle East and North Africa.", "authors": [{"family": "Abdel-Rahman", "given": "Suzan", "initials": "S"}, {"family": "Awwad", "given": "Fuad A", "initials": "FA"}, {"family": "Qasim", "given": "Muhammad", "initials": "M"}, {"family": "Abonazel", "given": "Mohamed R", "initials": "MR"}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "issn-l": null, "volume": "9", "issue": "7", "pages": "e17705"}, "abstract": "The COVID-19 pandemic has significantly altered employment and income distribution, impacting women and men differently. This study investigates the negative effects of COVID-19 on the labour market, focusing on the gender gap in five countries in the Middle East and North Africa (MENA) region. The study indicates whether women are more susceptible to losing their jobs, either temporarily or permanently, switching their primary occupation, and experiencing decreased working hours and income compared to men during the COVID-19 outbreak. The study utilizes a multivariate Probit model to estimate the relationship between gender and adverse labour outcomes controlling for correlations among outcomes. Data are obtained from the Combined COVID-19 MENA Monitor Household Survey, covering Egypt, Tunisia, Morocco, Jordan, and Sudan. The findings of this study offer empirical evidence of the gender gap in labour market outcomes during the pandemic. Women are more likely than men to experience negative work outcomes, such as permanent job loss and change in their main job. The increased childcare and housework responsibilities have significantly impacted women's labour market outcomes during the pandemic. However, the availability of telework has reduced the likelihood of job loss among women. The study's results contribute to a better understanding of the impact of COVID-19 on gender inequality in understudied MENA countries. Mitigation policies should focus on supporting vulnerable women who have experienced disproportionate negative effects of COVID-19.", "doi": "10.1016/j.heliyon.2023.e17705", "pmid": "37456038", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10338972"}, {"db": "pii", "key": "S2405-8440(23)04913-7"}], "notes": [], "created": "2023-10-04T12:09:05.868Z", "modified": "2023-10-04T12:49:06.026Z"}, {"entity": "publication", "iuid": "c2ca3f8574624b31bb877b6129945208", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2ca3f8574624b31bb877b6129945208.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2ca3f8574624b31bb877b6129945208"}}, "title": "Mucosal immune responses following a fourth SARS-CoV-2 vaccine dose.", "authors": [{"family": "Bladh", "given": "Oscar", "initials": "O"}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Norin", "given": "Nina Greilert", "initials": "NG"}, {"family": "Aguilera", "given": "Katherina", "initials": "K"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "letter", "published": "2023-07-00", "journal": {"title": "The Lancet Microbe", "issn": "2666-5247", "volume": "4", "issue": "7", "pages": "e488", "issn-l": "2666-5247"}, "abstract": null, "doi": "10.1016/S2666-5247(23)00102-7", "pmid": "37086736", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pmc", "key": "PMC10115585"}, {"db": "pii", "key": "S2666-5247(23)00102-7"}], "notes": [], "created": "2023-07-13T11:38:02.948Z", "modified": "2023-07-13T11:38:42.510Z"}, {"entity": "publication", "iuid": "c1ef68d3ddce4d4ea525ceeccd27a474", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1ef68d3ddce4d4ea525ceeccd27a474.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1ef68d3ddce4d4ea525ceeccd27a474"}}, "title": "Impact of the COVID-19 pandemic on Swedish adults aged 77 years and older: Age differences in lifestyle changes.", "authors": [{"family": "Augustsson", "given": "Erika", "initials": "E", "orcid": "0000-0001-9958-4090", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0cd1d8d125cc426e9c0d9c587fbc9513.json"}}, {"family": "Von Saenger", "given": "Isabelle", "initials": "I"}, {"family": "Agahi", "given": "Neda", "initials": "N"}, {"family": "K\u00e5reholt", "given": "Ingemar", "initials": "I"}, {"family": "Ericsson", "given": "Malin", "initials": "M"}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": "51", "issue": "5", "pages": "764-768"}, "abstract": "This study aimed to describe the impact of the COVID-19 pandemic on lifestyle and social activities among older adults in Sweden, with a special focus on differences between the 'younger old' (aged 77-84) and 'older old' (aged 85-109).\r\n\r\nThis study is based on a nationally representative sample of older adults (aged \u2a7e77 years) in Sweden (SWEOLD). Data were collected between May 2021 and April 2022, when many recommendations were removed but the virus was still classified as a public health disease. We studied occurrences and differences between the two age groups in several lifestyle factors and social activities.\r\n\r\nThe younger old displayed larger changes in lifestyles because of the pandemic than the older old. Most changes were found in social interactions with family.\r\n\r\nOur results highlight the large heterogeneity within the Swedish population aged \u2a7e77 years, and that the younger old experienced a bigger lifestyle change than the older old. Previous activity levels might be important to consider in order to understand how regulations may affect the older population. Finally, our findings indicate large age differences in Internet use, which require attention to prevent digital exclusion of an already vulnerable group.", "doi": "10.1177/14034948231172249", "pmid": "37151122", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10170261"}], "notes": [], "created": "2023-10-04T05:12:01.762Z", "modified": "2023-10-04T07:26:10.285Z"}, {"entity": "publication", "iuid": "41d8faa1aee942a1b8f3986561852142", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41d8faa1aee942a1b8f3986561852142.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41d8faa1aee942a1b8f3986561852142"}}, "title": "ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies.", "authors": [{"family": "Grasselli", "given": "Giacomo", "initials": "G", "orcid": "0000-0002-1735-1400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a68eafa11dae413bb14842cfb8647144.json"}}, {"family": "Calfee", "given": "Carolyn S", "initials": "CS"}, {"family": "Camporota", "given": "Luigi", "initials": "L"}, {"family": "Poole", "given": "Daniele", "initials": "D"}, {"family": "Amato", "given": "Marcelo B P", "initials": "MBP"}, {"family": "Antonelli", "given": "Massimo", "initials": "M"}, {"family": "Arabi", "given": "Yaseen M", "initials": "YM"}, {"family": "Baroncelli", "given": "Francesca", "initials": "F"}, {"family": "Beitler", "given": "Jeremy R", "initials": "JR"}, {"family": "Bellani", "given": "Giacomo", "initials": "G"}, {"family": "Bellingan", "given": "Geoff", "initials": "G"}, {"family": "Blackwood", "given": "Bronagh", "initials": "B"}, {"family": "Bos", "given": "Lieuwe D J", "initials": "LDJ"}, {"family": "Brochard", "given": "Laurent", "initials": "L"}, {"family": "Brodie", "given": "Daniel", "initials": "D"}, {"family": "Burns", "given": "Karen E A", "initials": "KEA"}, {"family": "Combes", "given": "Alain", "initials": "A"}, {"family": "D'Arrigo", "given": "Sonia", "initials": "S"}, {"family": "De Backer", "given": "Daniel", "initials": "D"}, {"family": "Demoule", "given": "Alexandre", "initials": "A"}, {"family": "Einav", "given": "Sharon", "initials": "S"}, {"family": "Fan", "given": "Eddy", "initials": "E"}, {"family": "Ferguson", "given": "Niall D", "initials": "ND"}, {"family": "Frat", "given": "Jean-Pierre", "initials": "J"}, {"family": "Gattinoni", "given": "Luciano", "initials": "L"}, {"family": "Gu\u00e9rin", "given": "Claude", "initials": "C"}, {"family": "Herridge", "given": "Margaret S", "initials": "MS"}, {"family": "Hodgson", "given": "Carol", "initials": "C"}, {"family": "Hough", "given": "Catherine L", "initials": "CL"}, {"family": "Jaber", "given": "Samir", "initials": "S"}, {"family": "Juffermans", "given": "Nicole P", "initials": "NP"}, {"family": "Karagiannidis", "given": "Christian", "initials": "C"}, {"family": "Kesecioglu", "given": "Jozef", "initials": "J"}, {"family": "Kwizera", "given": "Arthur", "initials": "A"}, {"family": "Laffey", "given": "John G", "initials": "JG"}, {"family": "Mancebo", "given": "Jordi", "initials": "J"}, {"family": "Matthay", "given": "Michael A", "initials": "MA"}, {"family": "McAuley", "given": "Daniel F", "initials": "DF"}, {"family": "Mercat", "given": "Alain", "initials": "A"}, {"family": "Meyer", "given": "Nuala J", "initials": "NJ"}, {"family": "Moss", "given": "Marc", "initials": "M"}, {"family": "Munshi", "given": "Laveena", "initials": "L"}, {"family": "Myatra", "given": "Sheila N", "initials": "SN"}, {"family": "Ng Gong", "given": "Michelle", "initials": "M"}, {"family": "Papazian", "given": "Laurent", "initials": "L"}, {"family": "Patel", "given": "Bhakti K", "initials": "BK"}, {"family": "Pellegrini", "given": "Mariangela", "initials": "M"}, {"family": "Perner", "given": "Anders", "initials": "A"}, {"family": "Pesenti", "given": "Antonio", "initials": "A"}, {"family": "Piquilloud", "given": "Lise", "initials": "L"}, {"family": "Qiu", "given": "Haibo", "initials": "H"}, {"family": "Ranieri", "given": "Marco V", "initials": "MV"}, {"family": "Riviello", "given": "Elisabeth", "initials": "E"}, {"family": "Slutsky", "given": "Arthur S", "initials": "AS"}, {"family": "Stapleton", "given": "Renee D", "initials": "RD"}, {"family": "Summers", "given": "Charlotte", "initials": "C"}, {"family": "Thompson", "given": "Taylor B", "initials": "TB"}, {"family": "Valente Barbas", "given": "Carmen S", "initials": "CS"}, {"family": "Villar", "given": "Jes\u00fas", "initials": "J"}, {"family": "Ware", "given": "Lorraine B", "initials": "LB"}, {"family": "Weiss", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Zampieri", "given": "Fernando G", "initials": "FG"}, {"family": "Azoulay", "given": "Elie", "initials": "E"}, {"family": "Cecconi", "given": "Maurizio", "initials": "M"}, {"family": "European Society of Intensive Care Medicine Taskforce on ARDS", "given": "", "initials": ""}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "issn-l": "0342-4642", "volume": "49", "issue": "7", "pages": "727-759"}, "abstract": "The aim of these guidelines is to update the 2017 clinical practice guideline (CPG) of the European Society of Intensive Care Medicine (ESICM). The scope of this CPG is limited to adult patients and to non-pharmacological respiratory support strategies across different aspects of acute respiratory distress syndrome (ARDS), including ARDS due to coronavirus disease 2019 (COVID-19). These guidelines were formulated by an international panel of clinical experts, one methodologist and patients' representatives on behalf of the ESICM. The review was conducted in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement recommendations. We followed the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to assess the certainty of evidence and grade recommendations and the quality of reporting of each study based on the EQUATOR (Enhancing the QUAlity and Transparency Of health Research) network guidelines. The CPG addressed 21 questions and formulates 21 recommendations on the following domains: (1) definition; (2) phenotyping, and respiratory support strategies including (3) high-flow nasal cannula oxygen (HFNO); (4) non-invasive ventilation (NIV); (5) tidal volume setting; (6) positive end-expiratory pressure (PEEP) and recruitment maneuvers (RM); (7) prone positioning; (8) neuromuscular blockade, and (9) extracorporeal life support (ECLS). In addition, the CPG includes expert opinion on clinical practice and identifies the areas of future research.", "doi": "10.1007/s00134-023-07050-7", "pmid": "37326646", "labels": {"Category: Health": null, "Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10354163"}, {"db": "pii", "key": "10.1007/s00134-023-07050-7"}], "notes": [], "created": "2023-10-04T09:33:16.169Z", "modified": "2023-10-04T11:21:30.227Z"}, {"entity": "publication", "iuid": "2c8feac8e069488c974dd20db5646552", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c8feac8e069488c974dd20db5646552.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c8feac8e069488c974dd20db5646552"}}, "title": "Does misclassification of former tobacco smokers explain the 'smoker's paradox' in the risk of COVID-19? Insights from the Stockholm Public Health Cohort.", "authors": [{"family": "Shaaban", "given": "Ahmed N", "initials": "AN", "orcid": "0000-0001-8483-638X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b418a223c2054c459cc35896e4ee98db.json"}}, {"family": "Andersson", "given": "Filip", "initials": "F"}, {"family": "Magnusson", "given": "Cecilia", "initials": "C"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}, {"family": "Caspersen", "given": "Ida H", "initials": "IH"}, {"family": "Pe\u00f1a", "given": "Sebastian", "initials": "S"}, {"family": "Karvonen", "given": "Sakari", "initials": "S"}, {"family": "Magnus", "given": "Per", "initials": "P"}, {"family": "Galanti", "given": "Maria R", "initials": "MR", "orcid": "0000-0002-7805-280X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8bc2f32ea87d4ddc9710aad0834aafc5.json"}}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": "51", "issue": "5", "pages": "735-743"}, "abstract": "The association between tobacco smoking and the risk of COVID-19 and its adverse outcomes is controversial, as studies reported contrasting findings. Bias due to misclassification of the exposure in the analyses of current versus non-current smoking could be a possible explanation because former smokers may have higher background risks of the disease due to co-morbidity. The aim of the study was to investigate the extent of this potential bias by separating non-, former, and current smokers when assessing the risk or prognosis of diseases.\r\n\r\nWe analysed data from 43,400 participants in the Stockholm Public Health Cohort, Sweden, with information on smoking obtained prior to the pandemic. We estimated the risk of COVID-19, hospital admissions and death for (a) former and current smokers relative to non-smokers, (b) current smokers relative to non-current smokers, that is, including former smokers; adjusting for potential confounders (aRR).\r\n\r\nThe aRR of a COVID-19 diagnosis was elevated for former smokers compared with non-smokers (1.07; 95% confidence interval (CI) =1.00-1.15); including hospital admission with any COVID-19 diagnosis (aRR= 1.23; 95% CI = 1.03-1.48); or with COVID-19 as the main diagnosis (aRR=1.23, 95% CI= 1.01-1.49); and death within 30 days with COVID-19 as the main or a contributory cause (aRR=1.40; 95% CI=1.00-1.95). Current smoking was negatively associated with risk of COVID-19 (aRR=0.79; 95% CI=0.68-0.91).\r\n\r\nSeparating non-smokers from former smokers when assessing the disease risk or prognosis is essential to avoid bias. However, the negative association between current smoking and the risk of COVID-19 could not be entirely explained by misclassification.", "doi": "10.1177/14034948231174279", "pmid": "37165603", "labels": {"Category: Public Health": null, "Funder: NordForsk": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10183343"}], "notes": [], "created": "2023-10-04T05:09:46.201Z", "modified": "2023-10-04T06:08:29.155Z"}, {"entity": "publication", "iuid": "3dd75d5ee69a4397abe43b08a078fe21", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3dd75d5ee69a4397abe43b08a078fe21.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3dd75d5ee69a4397abe43b08a078fe21"}}, "title": "Cost Effectiveness of Strategies for Caring for Critically Ill Patients with COVID-19 in Tanzania.", "authors": [{"family": "Shah", "given": "Hiral Anil", "initials": "HA", "orcid": "0000-0003-0204-451X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21ddc194342b4a8280e1c0977ced1d43.json"}}, {"family": "Baker", "given": "Tim", "initials": "T", "orcid": "0000-0001-8727-7018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1454fc20049b4d47865268adf16d104a.json"}}, {"family": "Schell", "given": "Carl Otto", "initials": "CO", "orcid": "0000-0002-7904-1336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a40b337b45b471d97a102c355c9d874.json"}}, {"family": "Kuwawenaruwa", "given": "August", "initials": "A", "orcid": "0000-0001-8459-443X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cbb1004e55d04aa6831d0f1ac9c51233.json"}}, {"family": "Awadh", "given": "Khamis", "initials": "K"}, {"family": "Khalid", "given": "Karima", "initials": "K", "orcid": "0000-0001-9917-9853", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7c34a2daebf4e0483d0de27357ce4db.json"}}, {"family": "Kairu", "given": "Angela", "initials": "A", "orcid": "0000-0002-0965-4460", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/655a16b5d0704794a9183726b74eee30.json"}}, {"family": "Were", "given": "Vincent", "initials": "V", "orcid": "0000-0002-3554-795X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59d578f5fe6d4fa0b015dc1fd609c932.json"}}, {"family": "Barasa", "given": "Edwine", "initials": "E", "orcid": "0000-0001-5793-7177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0487b77768174459af77fa6456cf5954.json"}}, {"family": "Baker", "given": "Peter", "initials": "P", "orcid": "0000-0001-9028-9976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/117923062b604fc0b2206c9adeef38b1.json"}}, {"family": "Guinness", "given": "Lorna", "initials": "L", "orcid": "0000-0002-1013-4200", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bf8da5dd3e24b669b1f58ea651be77a.json"}}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Pharmacoecon Open", "issn": "2509-4254", "issn-l": null, "volume": "7", "issue": "4", "pages": "537-552"}, "abstract": "The resources for critical care are limited in many settings, exacerbating the significant morbidity and mortality associated with critical illness. Budget constraints can lead to choices between investing in advanced critical care (e.g. mechanical ventilators in intensive care units) or more basic critical care such as Essential Emergency and Critical Care (EECC; e.g. vital signs monitoring, oxygen therapy, and intravenous fluids).\r\n\r\nWe investigated the cost effectiveness of providing EECC and advanced critical care in Tanzania in comparison with providing 'no critical care' or 'district hospital-level critical care' using coronavirus disease 2019 (COVID-19) as a tracer condition. We developed an open-source Markov model ( https://github.com/EECCnetwork/POETIC_CEA ) to estimate costs and disability-adjusted life-years (DALYs) averted, using a provider perspective, a 28-day time horizon, patient outcomes obtained from an elicitation method involving a seven-member expert group, a normative costing study, and published literature. We performed a univariate and probabilistic sensitivity analysis to assess the robustness of our results.\r\n\r\nEECC is cost effective 94% and 99% of the time when compared with no critical care (incremental cost-effectiveness ratio [ICER] $37 [-$9 to $790] per DALY averted) and district hospital-level critical care (ICER $14 [-$200 to $263] per DALY averted), respectively, relative to the lowest identified estimate of the willingness-to-pay threshold for Tanzania ($101 per DALY averted). Advanced critical care is cost effective 27% and 40% of the time, when compared with the no critical care or district hospital-level critical care scenarios, respectively.\r\n\r\nFor settings where there is limited or no critical care delivery, implementation of EECC could be a highly cost-effective investment. It could reduce mortality and morbidity for critically ill COVID-19 patients, and its cost effectiveness falls within the range considered 'highly cost effective'. Further research is needed to explore the potential of EECC to generate even greater benefits and value for money when patients with diagnoses other than COVID-19 are accounted for.", "doi": "10.1007/s41669-023-00418-x", "pmid": "37178434", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10181924"}, {"db": "pii", "key": "10.1007/s41669-023-00418-x"}], "notes": [], "created": "2023-10-04T05:11:10.509Z", "modified": "2023-10-04T07:08:57.586Z"}, {"entity": "publication", "iuid": "08c5680512c54af484164d9feb458e04", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/08c5680512c54af484164d9feb458e04.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/08c5680512c54af484164d9feb458e04"}}, "title": "Association between hypersomnolence and the COVID-19 pandemic: The International COVID-19 Sleep Study (ICOSS).", "authors": [{"family": "Sarkanen", "given": "Tomi", "initials": "T"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Merikanto", "given": "Ilona", "initials": "I"}, {"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Nadorff", "given": "Michael R", "initials": "MR"}, {"family": "Bolstad", "given": "Courtney J", "initials": "CJ"}, {"family": "Espie", "given": "Colin", "initials": "C"}, {"family": "Matsui", "given": "Kentaro", "initials": "K"}, {"family": "Chung", "given": "Frances", "initials": "F"}, {"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK"}, {"family": "Penzel", "given": "Thomas", "initials": "T"}, {"family": "Mac\u00eado", "given": "Tain\u00e1", "initials": "T"}, {"family": "Mota-Rolim", "given": "S\u00e9rgio", "initials": "S"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Plazzi", "given": "Giuseppe", "initials": "G"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L"}, {"family": "Landtblom", "given": "Anne-Marie", "initials": "A"}, {"family": "Inoue", "given": "Yuichi", "initials": "Y"}, {"family": "Sieminski", "given": "Mariuz", "initials": "M"}, {"family": "Leger", "given": "Damien", "initials": "D"}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y"}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Sleep Med", "issn": "1878-5506", "issn-l": null, "volume": "107", "issue": null, "pages": "108-115"}, "abstract": "The COVID-19 pandemic and related restriction measures have affected our daily life, sleep, and circadian rhythms worldwide. Their effects on hypersomnolence and fatigue remain unclear.\r\n\r\nThe International COVID-19 Sleep Study questionnaire which included items on hypersomnolence such as excessive daytime sleepiness (EDS), and excessive quantity of sleep (EQS), as well as sociodemographic factors, sleep patterns, psychological symptoms, and quality of life was distributed in 15 countries across the world from May to September in 2020.\r\n\r\nAltogether responses from 18,785 survey participants (65% women, median age 39 years) were available for analysis. Only 2.8% reported having had COVID-19. Compared to before the pandemic, the prevalence of EDS, EQS, and fatigue increased from 17.9% to 25.5%, 1.6%-4.9%, and 19.4%-28.3% amid the pandemic, respectively. In univariate logistic regression models, reports of having a COVID-19 were associated with EQS (OR 5.3; 95%-CI 3.6-8.0), EDS (2.6; 2.0-3.4), and fatigue (2.8; 2.1-3.6). In adjusted multivariate logistic regression, sleep duration shorter than desired (3.9; 3.2-4.7), depressive symptoms (3.1; 2.7-3.5), use of hypnotics (2.3; 1.9-2.8), and having reported COVID-19 (1.9; 1.3-2.6) remained strong predictors of EDS. Similar associations emerged for fatigue. In the multivariate model, depressive symptoms (4.1; 3.6-4.6) and reports of having COVID-19 (2.0; 1.4-2.8) remained associated with EQS.\r\n\r\nA large increase in EDS, EQS, and fatigue occurred due to the COVID-19 pandemic, and especially in self-reported cases of COVID-19. These findings warrant a thorough understanding of their pathophysiology to target prevention and treatment strategies for long COVID condition.", "doi": "10.1016/j.sleep.2023.04.024", "pmid": "37156053", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10163923"}, {"db": "pii", "key": "S1389-9457(23)00160-0"}], "notes": [], "created": "2023-10-04T05:10:28.509Z", "modified": "2023-10-04T06:43:00.331Z"}, {"entity": "publication", "iuid": "49656b81c61e436191b96dbd34ab2c02", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49656b81c61e436191b96dbd34ab2c02.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49656b81c61e436191b96dbd34ab2c02"}}, "title": "Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia in middle-income countries.", "authors": [{"family": "van de Munckhof", "given": "Anita", "initials": "A", "orcid": "0000-0001-6028-3426", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e0cc819c9fe4a0b89beb8c30ea0b6b6.json"}}, {"family": "Borhani-Haghighi", "given": "Afshin", "initials": "A", "orcid": "0000-0002-4131-7990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f8cc4b1e730435092ab97b92bbe4d36.json"}}, {"family": "Aaron", "given": "Sanjith", "initials": "S", "orcid": "0000-0002-5151-1500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98fdfb1034344016b5f0c16e10963382.json"}}, {"family": "Krzywicka", "given": "Katarzyna", "initials": "K"}, {"family": "van Kammen", "given": "Mayte S\u00e1nchez", "initials": "MS"}, {"family": "Cordonnier", "given": "Charlotte", "initials": "C"}, {"family": "Kleinig", "given": "Timothy J", "initials": "TJ"}, {"family": "Field", "given": "Thalia S", "initials": "TS", "orcid": "0000-0002-1176-0633", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f08f5ddffb74ae796f60cdf39b3ef8c.json"}}, {"family": "Poli", "given": "Sven", "initials": "S", "orcid": "0000-0002-0286-8781", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c953f4fa37054db9b0ea7127a5593847.json"}}, {"family": "Lemmens", "given": "Robin", "initials": "R"}, {"family": "Scutelnic", "given": "Adrian", "initials": "A"}, {"family": "Lindgren", "given": "Erik", "initials": "E"}, {"family": "Duan", "given": "Jiangang", "initials": "J"}, {"family": "Arslan", "given": "Y\u0131ld\u0131z", "initials": "Y"}, {"family": "van Gorp", "given": "Eric Cm", "initials": "EC"}, {"family": "Kremer Hovinga", "given": "Johanna A", "initials": "JA"}, {"family": "G\u00fcnther", "given": "Albrecht", "initials": "A"}, {"family": "Jood", "given": "Katarina", "initials": "K"}, {"family": "Tatlisumak", "given": "Turgut", "initials": "T"}, {"family": "Putaala", "given": "Jukka", "initials": "J"}, {"family": "Heldner", "given": "Mirjam R", "initials": "MR"}, {"family": "Arnold", "given": "Marcel", "initials": "M"}, {"family": "de Sousa", "given": "Diana Aguiar", "initials": "DA", "orcid": "0000-0002-6702-7924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cc3515119a247859fe1fea025f703ef.json"}}, {"family": "Wasay", "given": "Mohammad", "initials": "M", "orcid": "0000-0003-3750-2613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d31625317cd48779278fb20fee594a8.json"}}, {"family": "Arauz", "given": "Antonio", "initials": "A"}, {"family": "Conforto", "given": "Adriana Bastos", "initials": "AB"}, {"family": "Ferro", "given": "Jos\u00e9 M", "initials": "JM", "orcid": "0000-0002-2343-9097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c8285bcf71c4ed1aa7b57a13c5cb70a.json"}}, {"family": "Coutinho", "given": "Jonathan M", "initials": "JM"}, {"family": "Cerebral Venous Sinus Thrombosis with Thrombocytopenia Syndrome Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-06-30", "journal": {"title": "Int J Stroke", "issn": "1747-4949", "issn-l": null, "volume": null, "issue": null, "pages": "17474930231182901"}, "abstract": "Adenovirus-based COVID-19 vaccines are extensively used in low- and middle-income countries (LMICs). Remarkably, cases of cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) have rarely been reported from LMICs.\r\n\r\nWe studied the frequency, manifestations, treatment, and outcomes of CVST-VITT in LMICs.\r\n\r\nWe report data from an international registry on CVST after COVID-19 vaccination. VITT was classified according to the Pavord criteria. We compared CVST-VITT cases from LMICs to cases from high-income countries (HICs).\r\n\r\nUntil August 2022, 228 CVST cases were reported, of which 63 were from LMICs (all middle-income countries [MICs]: Brazil, China, India, Iran, Mexico, Pakistan, Turkey). Of these 63, 32 (51%) met the VITT criteria, compared to 103 of 165 (62%) from HICs. Only 5 of the 32 (16%) CVST-VITT cases from MICs had definite VITT, mostly because anti-platelet factor 4 antibodies were often not tested. The median age was 26 (interquartile range [IQR] 20-37) versus 47 (IQR 32-58) years, and the proportion of women was 25 of 32 (78%) versus 77 of 103 (75%) in MICs versus HICs, respectively. Patients from MICs were diagnosed later than patients from HICs (1/32 [3%] vs. 65/103 [63%] diagnosed before May 2021). Clinical manifestations, including intracranial hemorrhage, were largely similar as was intravenous immunoglobulin use. In-hospital mortality was lower in MICs (7/31 [23%, 95% confidence interval (CI) 11-40]) than in HICs (44/102 [43%, 95% CI 34-53], p = 0.039).\r\n\r\nThe number of CVST-VITT cases reported from LMICs was small despite the widespread use of adenoviral vaccines. Clinical manifestations and treatment of CVST-VITT cases were largely similar in MICs and HICs, while mortality was lower in patients from MICs.", "doi": "10.1177/17474930231182901", "pmid": "37277922", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:32:36.532Z", "modified": "2023-10-04T11:12:08.100Z"}, {"entity": "publication", "iuid": "b5297743cde049d68ec810db8b68c822", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5297743cde049d68ec810db8b68c822.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5297743cde049d68ec810db8b68c822"}}, "title": "Post-COVID sequelae effect in chronic fatigue syndrome: SARS-CoV-2 triggers latent adenovirus in the oral mucosa.", "authors": [{"family": "Hannestad", "given": "Ulf", "initials": "U"}, {"family": "Apostolou", "given": "Eirini", "initials": "E"}, {"family": "Sj\u00f6gren", "given": "Per", "initials": "P"}, {"family": "Brag\u00e9e", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Polo", "given": "Olli", "initials": "O"}, {"family": "Bertilson", "given": "Bo Christer", "initials": "BC"}, {"family": "Ros\u00e9n", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2023-06-29", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "issn-l": null, "volume": "10", "issue": null, "pages": "1208181"}, "abstract": "The post-viral fatigue syndromes long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have multiple, potentially overlapping, pathological processes. These include persisting reservoirs of virus, e.g., SARS-CoV-2 in long COVID patient's tissues, immune dysregulation with or without reactivation of underlying pathogens, such as Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV6), as we recently described in ME/CFS, and possibly yet unidentified viruses. In the present study we tested saliva samples from two cohorts for IgG against human adenovirus (HAdV): patients with ME/CFS (n = 84) and healthy controls (n = 94), with either mild/asymptomatic SARS-CoV-2 infection or no infection. A significantly elevated anti-HAdV IgG response after SARS-CoV-2 infection was detected exclusively in the patient cohort. Longitudinal/time analysis, before and after COVID-19, in the very same individuals confirmed HAdV IgG elevation after. In plasma there was no HAdV IgG elevation. We conclude that COVID-19 triggered reactivation of dormant HAdV in the oral mucosa of chronic fatigue patients indicating an exhausted dysfunctional antiviral immune response in ME/CFS, allowing reactivation of adenovirus upon stress encounter such as COVID-19. These novel findings should be considered in clinical practice for identification of patients that may benefit from therapy that targets HAdV as well.", "doi": "10.3389/fmed.2023.1208181", "pmid": "37457558", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC10349329"}], "notes": [], "created": "2023-10-04T12:07:38.054Z", "modified": "2023-10-04T12:21:18.720Z"}, {"entity": "publication", "iuid": "3fa5cfcbec3f42e798406ff5e9e3d1d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3fa5cfcbec3f42e798406ff5e9e3d1d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3fa5cfcbec3f42e798406ff5e9e3d1d9"}}, "title": "One year safety and immunogenicity of AZD1222 (ChAdOx1 nCoV-19): Final analysis of a randomized, placebo-controlled phase 1/2 trial in Japan.", "authors": [{"family": "Ishikawa", "given": "Kensuke", "initials": "K"}, {"family": "Nascimento", "given": "Maria-Claudia", "initials": "M"}, {"family": "Asano", "given": "Michiko", "initials": "M"}, {"family": "Hirata", "given": "Hajime", "initials": "H"}, {"family": "Itoh", "given": "Yohji", "initials": "Y"}, {"family": "Kelly", "given": "Elizabeth J", "initials": "EJ"}, {"family": "Matsui", "given": "Akiko", "initials": "A"}, {"family": "Olsson", "given": "Urban", "initials": "U"}, {"family": "Shoemaker", "given": "Kathryn", "initials": "K"}, {"family": "Green", "given": "Justin", "initials": "J"}], "type": "randomized controlled trial", "published": "2023-06-29", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null, "volume": "41", "issue": "29", "pages": "4199-4205"}, "abstract": "Long duration trial data for two-dose COVID-19 vaccines primary series' are uncommon due to unblinding and additional doses. We report one-year follow-up results from a phase 1/2 trial of AZD1222 (ChAdOx1 nCoV-19) in Japan.\r\n\r\nAdults (n = 256) seronegative for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) were stratified by age, 18-55 (n = 128), 56-69 (n = 86) and \u226570-year-old (n = 42), and randomized 3:1 to AZD1222 or placebo. Safety, immunogenicity, and exploratory efficacy data were collected until study Day 365.\r\n\r\nSafety was consistent with previous reports. In AZD1222 vaccinees, humoral responses against SARS-CoV-2 steadily declined over time. By Day 365, anti-SARS-CoV-2 spike-binding (spike) and receptor-binding domain (RBD) mean antibody titers remained above Day 15 levels and pseudovirus neutralizing antibodies were undetectable in many participants.\r\n\r\nAZD1222 is immunogenic and well tolerated in Japanese adults. Expected waning in anti-SARS-CoV-2 humoral responses was observed; spike and RBD antibody titers remained elevated. (ClinicalTrials.gov: NCT04568031).", "doi": "10.1016/j.vaccine.2023.05.015", "pmid": "37271703", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10237326"}, {"db": "pii", "key": "S0264-410X(23)00542-X"}, {"db": "ClinicalTrials.gov", "key": "NCT04568031"}], "notes": [], "created": "2023-10-04T09:30:12.084Z", "modified": "2023-10-04T09:51:35.301Z"}, {"entity": "publication", "iuid": "cca3bfbe17894d229c006db8e4a464d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cca3bfbe17894d229c006db8e4a464d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cca3bfbe17894d229c006db8e4a464d7"}}, "title": "Changes in trauma-related emergency medical services during the COVID-19 lockdown in the Western Cape, South Africa.", "authors": [{"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Stassen", "given": "Willem", "initials": "W"}, {"family": "Laflamme", "given": "Lucie", "initials": "L"}, {"family": "Wallis", "given": "Lee Alan", "initials": "LA"}, {"family": "Hasselberg", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2023-06-27", "journal": {"title": "BMC Emerg Med", "issn": "1471-227X", "issn-l": null, "volume": "23", "issue": "1", "pages": "72"}, "abstract": "To limit virus spread during the COVID pandemic, extensive measures were implemented around the world. In South Africa, these restrictions included alcohol and movement restrictions, factors previously linked to injury burden in the country. Consequently, reports from many countries, including South Africa, have shown a reduction in trauma presentations related to these restrictions. However, only few studies and none from Africa focus on the impact of the pandemic restrictions on the Emergency Medical System (EMS).\r\n\r\nWe present a retrospective, observational longitudinal study including data from all ambulance transports of physical trauma cases collected during the period 2019-01-01 and 2021-02-28 from the Western Cape Government EMS in the Western Cape Province, South Africa (87,167 cases). Within this timeframe, the 35-days strictest lockdown level period was compared to a 35-days period prior to the lockdown and to the same 35-days period in 2019. Injury characteristics (intent, mechanism, and severity) and time were studied in detail. Ambulance transport volumes as well as ambulance response and on-scene time before and during the pandemic were compared. Significance between indicated periods was determined using Chi-square test.\r\n\r\nDuring the strictest lockdown period, presentations of trauma cases declined by > 50%. Ambulance transport volumes decreased for all injury mechanisms and proportions changed. The share of assaults and traffic injuries decreased by 6% and 8%, respectively, while accidental injuries increased by 5%. The proportion of self-inflicted injuries increased by 5%. Studies of injury time showed an increased share of injuries during day shift and a reduction of total injury volume during the weekend during the lockdown. Median response- and on-scene time remained stable in the time-periods studied.\r\n\r\nThis is one of the first reports on the influence of COVID-19 related restrictions on EMS, and the first in South Africa. We report a decline in trauma related ambulance transport volumes in the Western Cape Province as well as changes in injury patterns, largely corresponding to previous findings from hospital settings in South Africa. The unchanged response and on-scene times indicate a well-functioning EMS despite pandemic challenges. More studies are needed, especially disaggregating the different restrictions.", "doi": "10.1186/s12873-023-00840-8", "pmid": "37370047", "labels": {"Category: Health": null, "Category: Other": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10304331"}, {"db": "pii", "key": "10.1186/s12873-023-00840-8"}], "notes": [], "created": "2023-10-04T09:33:06.004Z", "modified": "2023-10-04T11:16:08.902Z"}, {"entity": "publication", "iuid": "2b0291b59f914953869fbec4b66b3bd4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b0291b59f914953869fbec4b66b3bd4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b0291b59f914953869fbec4b66b3bd4"}}, "title": "Students at a crossroad: A cross-sectional survey gauging the impact of COVID-19 on medical and biomedical graduates in the United States and Sweden.", "authors": [{"family": "Lange", "given": "Stephan", "initials": "S", "orcid": "0000-0001-9361-6602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d15f59268b2e47c58612b025e48707bb.json"}}, {"family": "Sot\u00e1k", "given": "Mat\u00fa\u0161", "initials": "M", "orcid": "0000-0002-9984-9340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/238be0180b0f499f9eb0fe69d7b0389a.json"}}, {"family": "Hagberg", "given": "Carolina E", "initials": "CE"}, {"family": "Bagunu", "given": "Grace", "initials": "G"}, {"family": "Vigmo", "given": "Sylvi", "initials": "S"}, {"family": "B\u00f6rgeson", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2023-06-24", "journal": {"title": "Biochem Mol Biol Educ", "issn": "1539-3429", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Graduate programs in medicine and biomedical sciences have been severely impacted by the SARS-CoV-2/COVID-19 pandemic over the last 2 years. Following 2 years since beginning of the pandemic, data on student support, educational and academic performance as well as sentiment on changes to educational programs are starting to emerge. We performed and compared results of two cross-sectional surveys of Swedish and U.S.-based medical and biomedical graduate students on how the pandemic has affected their studies, research productivity and career trajectory. Students were also asked to assess support provided by the university and supervisors. The surveys also captured student demographics and a range of other factors, such as pressures brought on by caretaking and financial responsibilities. We analyzed answers from 264 and 106 students attending graduate programs in universities in Sweden and the United States, respectively. U.S.-based students faced more severe restrictions on their research program compared to students in Sweden, reporting more delays in productivity, scientific output and graduation, and increased worries about their career trajectory. Swedish students had more caretaking responsibilities, although these did not cause any delays in graduation. While support by universities and supervisors was comparable between the countries, financial worries and mental health concerns were particularly prominent in the U.S. cohort. Student performance and outlook was hugely dependent on the breadth of the restrictions and the available support. Besides the governmental and university-led approach to counter the pandemic, societal differences also played a role in how well students were handling effects of the pandemic.", "doi": "10.1002/bmb.21761", "pmid": "37354049", "labels": {"Category: Social Science & Humanities": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:30:48.915Z", "modified": "2023-10-04T10:05:44.722Z"}, {"entity": "publication", "iuid": "a9ee88d043544386b7c7616bb638f012", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a9ee88d043544386b7c7616bb638f012.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a9ee88d043544386b7c7616bb638f012"}}, "title": "Patient reported experiences of Swedish patients being investigated for cancer during the Covid-19 pandemic.", "authors": [{"family": "Tufvesson Stiller", "given": "Helena", "initials": "H", "orcid": "0000-0001-5213-9555", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9e04f2b00a5436192e564e3b0af08cb.json"}}, {"family": "Schmitt-Egenolf", "given": "Marcus", "initials": "M", "orcid": "0000-0002-3858-8474", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84d3fdbf4946483b9651365b34f2333e.json"}}, {"family": "Fohlin", "given": "Helena", "initials": "H", "orcid": "0000-0003-4336-0949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/142b56d58aec4dfab0f217cb3e334a52.json"}}, {"family": "Uppugunduri", "given": "Srinivas", "initials": "S", "orcid": "0000-0003-0572-5580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e6b350c35264d8db2606af67303deed.json"}}], "type": "journal article", "published": "2023-06-24", "journal": {"title": "Support Care Cancer", "issn": "1433-7339", "issn-l": null, "volume": "31", "issue": "7", "pages": "416"}, "abstract": "Patient reported experiences in individuals being investigated for cancer have been recorded in a nationwide survey in Sweden, providing an opportunity to assess the impact of the Covid-19-pandemic.\r\n\r\nQuestionnaires from 45920 patients were analyzed to assess the experience of being investigated for cancer. Data from before the Covid-19-pandemic (2018-2019) was compared to data acquired during the pandemic (2020-2021), using chi-square and Wilcoxon rank sum tests. Both, patients who were cleared from suspicion of cancer and those who were diagnosed with cancer were included.\r\n\r\nFewer patients in total visited health services during the pandemic. However, patients that did seek help did so to a similar extent during as prior to the pandemic. Patient waiting time was perceived to be shorter during the pandemic and judged as neither too long nor too short by most patients. The emotional support to patients improved during the pandemic, whereas the support to next of kin declined. A majority of patients received the results from the investigation in a meeting with the physician. Although there was a preference for receiving results in a meeting with the physician, the pandemic has brought an increasing interest in receiving results by phone.\r\n\r\nSwedish cancer healthcare has shown resilience during the Covid-19-pandemic, maintaining high patient satisfaction while working under conditions of extraordinary pressure. Patients became more open to alternatives to physical \"in person\" health care visits which could lead to more digital visits in the future. However, support to significant others demands special attention.", "doi": "10.1007/s00520-023-07897-y", "pmid": "37354327", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10290588"}, {"db": "pii", "key": "10.1007/s00520-023-07897-y"}], "notes": [], "created": "2023-10-04T09:31:03.603Z", "modified": "2023-10-04T10:41:54.531Z"}, {"entity": "publication", "iuid": "b574a09ae6e4410d84166c128e63fc42", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b574a09ae6e4410d84166c128e63fc42.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b574a09ae6e4410d84166c128e63fc42"}}, "title": "Pulmonary embolism and deep venous thrombosis after COVID-19: long-term risk in a population-based cohort study.", "authors": [{"family": "Sjoland", "given": "Helen", "initials": "H"}, {"family": "Lindgren", "given": "Martin", "initials": "M"}, {"family": "Toska", "given": "Triantafyllia", "initials": "T"}, {"family": "Hansson", "given": "Per-Olof", "initials": "P"}, {"family": "Sandblad", "given": "Katarina Glise", "initials": "KG"}, {"family": "Alex", "given": "Christian", "initials": "C"}, {"family": "Bjorck", "given": "Lena", "initials": "L"}, {"family": "Cronie", "given": "Ottmar", "initials": "O"}, {"family": "Bjork", "given": "Jonas", "initials": "J"}, {"family": "Lundberg", "given": "Christina E", "initials": "CE"}, {"family": "Adiels", "given": "Martin", "initials": "M"}, {"family": "Rosengren", "given": "Annika", "initials": "A"}], "type": "journal article", "published": "2023-06-21", "journal": {"title": "Res Pract Thromb Haemost", "issn": "2475-0379", "issn-l": null, "volume": "7", "issue": "5", "pages": "100284"}, "abstract": "Venous thromboembolism (VTE) (pulmonary embolism (PE) or deep venous thrombosis (DVT)) is common during acute COVID-19. Long-term excess risk has not yet been established.\r\n\r\nTo study long-term VTE risk after COVID-19.\r\n\r\nSwedish citizens aged 18-84 years, hospitalized and/or testing positive for COVID-19 between January 1, 2020, and September 11, 2021 (exposed), stratified by initial hospitalization, were compared to matched (1:5) non-exposed population-derived subjects without COVID-19. Outcomes were incident VTE, PE or DVT recorded within 60, 60-<180, and \u2265180 days. Cox regression was used for evaluation and a model adjusted for age, sex, comorbidities and socioeconomic markers developed to control for confounders.\r\n\r\nAmong exposed patients, 48,861 were hospitalized for COVID-19 (mean age 60.6 years) and 894,121 were without hospitalization (mean age 41.4 years). Among patients hospitalized for COVID-19, fully adjusted hazard ratios (HRs) during 60-<180 days were 6.05 (95% confidence interval (CI) 4.80\u25007.62) for PE and 3.97 (CI 2.96\u25005.33) for DVT, compared to non-exposed with corresponding estimates among COVID-19 without hospitalization 1.17 (CI 1.01\u25001.35) and 0.99 (CI 0.86\u25001.15), based on 475 and 2,311 VTE events, respectively. Long-term (\u2265180 days) HRs in patients hospitalized for COVID-19 were 2.01 (CI 1.51\u25002.68) for PE and 1.46 (CI 1.05\u25002.01) for DVT while non-hospitalized had similar risk to non-exposed, based on 467 and 2,030 VTE events, respectively.\r\n\r\nPatients hospitalized for COVID-19 retained an elevated excess risk of VTE, mainly PE, after 180 days, while long-term risk of VTE in individuals with COVID-19 without hospitalization was similar to the non-exposed.", "doi": "10.1016/j.rpth.2023.100284", "pmid": "37361398", "labels": {"Category: Health": null, "Category: Post-COVID": null, "Funder: VR": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10284449"}, {"db": "pii", "key": "S2475-0379(23)00184-X"}], "notes": [], "created": "2023-10-04T09:30:14.456Z", "modified": "2023-10-04T09:52:58.203Z"}, {"entity": "publication", "iuid": "9045fd55bc8e4a38aea3884a3373343a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9045fd55bc8e4a38aea3884a3373343a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9045fd55bc8e4a38aea3884a3373343a"}}, "title": "COVID-19-related stigma among infected people in Sweden; psychometric properties and levels of stigma in two cohorts as measured by a COVID-19 stigma scale.", "authors": [{"family": "Reinius", "given": "Maria", "initials": "M"}, {"family": "Svedhem", "given": "Veronica", "initials": "V"}, {"family": "Bruchfeld", "given": "Judith", "initials": "J"}, {"family": "Holmstr\u00f6m Larm", "given": "Heidi", "initials": "H"}, {"family": "Nygren-Bonnier", "given": "Malin", "initials": "M"}, {"family": "Eriksson", "given": "Lars E", "initials": "LE", "orcid": "0000-0001-5121-5325", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09bec95869bc450aa97e0aa11485807e.json"}}], "type": "journal article", "published": "2023-06-21", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "6", "pages": "e0287341"}, "abstract": "Epidemics have historically been accompanied by stigma and discrimination. Disease-related stigma has often been shown to have severe consequences for physical, mental and social wellbeing and lead to barriers to diagnosis, treatment and prevention. The aims of this study were to investigate if a HIV-related stigma measure could be adapted and valid and reliable to measure COVID-19-related stigma, and also to investigate levels of self-reported stigma and related factors among people in Sweden with experience of COVID-19 and compare levels of COVID-19-related stigma versus HIV-related stigma among persons living with HIV who had experienced a COVID-19 event.\r\n\r\nCognitive interviews (n = 11) and cross-sectional surveys were made after the acute phase of the illness using a new 12-item COVID-19 Stigma Scale and the established 12-item HIV Stigma Scale in two cohorts (people who had experienced COVID-19 (n = 166/209, 79%) and people living with HIV who had experienced a COVID-19 event (n = 50/91, 55%). Psychometric analysis of the COVID-19 Stigma Scale was performed by calculating floor and ceiling effects, Cronbach's \u03b1 and exploratory factor analysis. Levels of COVID-19 stigma between groups were analysed using the Mann-Whitney U test. Levels of COVID-19 and HIV stigma among people living with HIV with a COVID-19 event were compared using the Wilcoxon signed-rank test.\r\n\r\nThe COVID-19 cohort consisted of 88 (53%) men and 78 (47%) women, mean age 51 (19-80); 143 (87%) living in a higher and 22 (13%) in a lower income area. The HIV + COVID-19 cohort consisted of 34 (68%) men and 16 (32%) women, mean age 51 (26-79); 20 (40%) living in a higher and 30 (60%) in a lower income area. The cognitive interviews showed that the stigma items were easy to understand. Factor analysis suggested a four-factor solution accounting for 77% of the total variance. There were no cross loadings, but two items loaded on factors differing from the original scale. All subscales had acceptable internal consistency, showed high floor and no ceiling effects. There was no statistically significant difference between COVID-19 stigma scores between the two cohorts or between genders. People living in lower income areas reported more negative self-image and concerns about public attitudes related to COVID-19 than people in higher income areas (median score 3 vs 3 and 4 vs 3 on a scale from 3-12, Z = -1.980, p = 0.048 and Z = -2.023, p = 0.024, respectively). People from the HIV + COVID-19 cohort reported more HIV than COVID-19 stigma.\r\n\r\nThe adapted 12-item COVID-19 Stigma Scale may be valid and reliable for measurement of COVID-19-related stigma. However, specific items may need to be rephrased or replaced to better correspond to the COVID-19 context. People who had experienced COVID-19 reported low levels of COVID-19-related stigma in general but people from lower income areas had higher levels of negative self-image and concerns about public attitudes related to COVID-19 than people from areas with higher income, which may call for targeted interventions. Although exhibiting more pronounced HIV stigma levels, people living with HIV who had experienced COVID-19 reported COVID-19-related stigma of the same low magnitude as their peers not living with HIV.", "doi": "10.1371/journal.pone.0287341", "pmid": "37343027", "labels": {"Category: Social Science & Humanities": null, "Funder: VR": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10284413"}, {"db": "pii", "key": "PONE-D-22-35422"}], "notes": [], "created": "2023-10-04T09:30:07.232Z", "modified": "2023-10-04T09:48:40.291Z"}, {"entity": "publication", "iuid": "ae329cc718d04c629791e3fddd27d5ad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ae329cc718d04c629791e3fddd27d5ad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ae329cc718d04c629791e3fddd27d5ad"}}, "title": "Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity", "authors": [{"family": "Brunet-Ratnasingham", "given": "Elsa", "initials": "E", "orcid": "0000-0002-3613-1315", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae34faa98db04e62b0cdd39d9126b782.json"}}, {"family": "Morin", "given": "Sacha", "initials": "S"}, {"family": "Randolph", "given": "Haley E", "initials": "HE"}, {"family": "Labrecque", "given": "Marjorie", "initials": "M"}, {"family": "B\u00e9lair", "given": "Justin", "initials": "J"}, {"family": "Lima-Barbosa", "given": "Rapha\u00ebl", "initials": "R"}, {"family": "Pagliuzza", "given": "Am\u00e9lie", "initials": "A"}, {"family": "Marchitto", "given": "Lorie", "initials": "L"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Niessl", "given": "Julia", "initials": "J"}, {"family": "Cloutier", "given": "Rose", "initials": "R"}, {"family": "Sreng Flores", "given": "Alina M", "initials": "AM"}, {"family": "Brassard", "given": "Nathalie", "initials": "N"}, {"family": "Benlarbi", "given": "Mehdi", "initials": "M"}, {"family": "Pr\u00e9vost", "given": "J\u00e9r\u00e9mie", "initials": "J"}, {"family": "Ding", "given": "Shilei", "initials": "S"}, {"family": "Anand", "given": "Sai Priya", "initials": "SP"}, {"family": "Sannier", "given": "G\u00e9r\u00e9my", "initials": "G"}, {"family": "Bareke", "given": "Eric", "initials": "E"}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ee1510080704cf6a2a6972deb94123f.json"}}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Zhou", "given": "Sirui", "initials": "S"}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T", "orcid": "0000-0001-9510-5646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd273e50091d44c3b3e8d1473ce89b0a.json"}}, {"family": "Morrison", "given": "David", "initials": "D"}, {"family": "Vezina", "given": "Dani", "initials": "D"}, {"family": "Bourassa", "given": "Catherine", "initials": "C"}, {"family": "Gendron-Lepage", "given": "Gabrielle", "initials": "G"}, {"family": "Medjahed", "given": "Halima", "initials": "H"}, {"family": "Point", "given": "Floriane", "initials": "F"}, {"family": "Richard", "given": "Jonathan", "initials": "J"}, {"family": "Larochelle", "given": "Catherine", "initials": "C"}, {"family": "Prat", "given": "Alexandre", "initials": "A"}, {"family": "Arbour", "given": "Nathalie", "initials": "N"}, {"family": "Durand", "given": "Madeleine", "initials": "M"}, {"family": "Brent Richards", "given": "J", "initials": "J"}, {"family": "Moon", "given": "Kevin", "initials": "K"}, {"family": "Chomont", "given": "Nicolas", "initials": "N", "orcid": "0000-0001-9747-5018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/477cede6c34e4908a8e806f6352d3daa.json"}}, {"family": "Finzi", "given": "Andr\u00e9s", "initials": "A"}, {"family": "T\u00e9treault", "given": "Martine", "initials": "M"}, {"family": "Barreiro", "given": "Luis", "initials": "L"}, {"family": "Wolf", "given": "Guy", "initials": "G"}, {"family": "Kaufmann", "given": "Daniel E", "initials": "DE", "orcid": "0000-0003-4467-136X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9581da3f05024ef68e4ded53cb9b413c.json"}}], "type": "posted-content", "published": "2023-06-20", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.06.14.23290814", "pmid": null, "labels": {"Funder: VR": null, "Category: Genomics & transcriptomics": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Preprint": null, "Category: Serology": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:30:00.232Z", "modified": "2023-10-04T09:44:01.052Z"}, {"entity": "publication", "iuid": "4b5a011592d14e78a026c78150d0dd7b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b5a011592d14e78a026c78150d0dd7b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b5a011592d14e78a026c78150d0dd7b"}}, "title": "Lessons learned from pandemic response to COVID-19 in Bangladesh: NGO-based emergency response framework for low- and middle-income countries.", "authors": [{"family": "Ahmed", "given": "Tanvir", "initials": "T", "orcid": "0000-0001-8147-5136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f6ebfebcb3a40128282c0fe6bf61720.json"}}, {"family": "Musarrat", "given": "Parsa", "initials": "P", "orcid": "0000-0002-4210-5228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c80b1a7a9ea4952bf1b7653121b0e4f.json"}}, {"family": "Kabir", "given": "Zarina Nahar", "initials": "ZN", "orcid": "0000-0003-0465-5701", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7e6bafbfd6843e188acefca5ce929b1.json"}}], "type": "journal article", "published": "2023-06-20", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "issn-l": null, "volume": "23", "issue": "1", "pages": "656"}, "abstract": "Response to COVID-19 pandemic in Bangladesh was led by the Government of Bangladesh aided by Non-Government Organisations (NGO) among others. The aim of the study was to explore the activities of such an NGO to understand the philosophy, aspiration and strategy to plan and implement an effective response to COVID-19 pandemic in Bangladesh.\r\n\r\nA case study of a Bangladeshi NGO called SAJIDA Foundation (SF) is presented. From September to November 2021, using document review, field observation and in-depth interviews, four aspects of their COVID-19 pandemic related activities was explored - a) why and how SF initiated their COVID response; b) what adaptations were made to their usual programmes; c) how SF's response to COVID-19 were designed and what were the anticipated challenges including overcoming measures; and d) perception of the staff about SF's activities related to COVID-19. Fifteen in-depth interviews were conducted with three groups of SF staff: frontliners, managers and leaders.\r\n\r\nThe impact of COVID-19 has been beyond health emergencies and posed multidimensional challenges. SF took a two-pronged approach - aid the government to respond to the emergency and adopt an all-inclusive plan to address diverse challenges related to overall well-being of the population. The underlying strategy of their response has been to: define the challenge of COVID-19 and identify required expertise and resources, ensure people's health and social wellbeing, adjust existing organisational processes, ensure functional partnership with other organisations for effective resource and task sharing, and safeguard health and wellbeing of the organisation's own employees.\r\n\r\nThe findings suggest a '4C framework' including four components as the basis of a comprehensive response to emergencies by NGOs: 1. Capability assessment to identify who are in need and what is needed; 2. Collaboration with stakeholders to pool resources and expertise; 3. Compassionate leadership to ensure health and social safety of the employees which ensures their dedication in managing the emergency; and 4. Communication for quick and effective decision making, decentralisation, monitoring and coordination. It is expected that this '4C framework' can help NGOs to embark on a comprehensive response to manage emergencies in resource constrained low- and middle-income countries.", "doi": "10.1186/s12913-023-09643-w", "pmid": "37340495", "labels": {"Category: Social Science & Humanities": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC10283326"}, {"db": "pii", "key": "10.1186/s12913-023-09643-w"}], "notes": [], "created": "2023-10-04T09:30:46.347Z", "modified": "2023-10-04T10:03:45.896Z"}, {"entity": "publication", "iuid": "68a74d771c8a49bf9f26e13b0dd56271", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68a74d771c8a49bf9f26e13b0dd56271.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68a74d771c8a49bf9f26e13b0dd56271"}}, "title": "Drug interventions for prevention of COVID-19 progression to severe disease in outpatients: a systematic review with meta-analyses and trial sequential analyses (The LIVING Project).", "authors": [{"family": "Petersen", "given": "Johanne Juul", "initials": "JJ", "orcid": "0000-0001-9837-1958", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37a5ab98e9c2454599584fc77f72efe1.json"}}, {"family": "J\u00f8rgensen", "given": "Caroline Kamp", "initials": "CK", "orcid": "0000-0002-7756-4694", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1b41bcfde8a482ab3c137ca4124baa3.json"}}, {"family": "Faltermeier", "given": "Pascal", "initials": "P"}, {"family": "Siddiqui", "given": "Faiza", "initials": "F", "orcid": "0000-0002-8358-6259", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/444713ae12884f5cb2f5909e82be8170.json"}}, {"family": "Feinberg", "given": "Joshua", "initials": "J", "orcid": "0000-0003-1975-9300", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76c4aae6c02047078131ddaf618684f5.json"}}, {"family": "Nielsen", "given": "Emil Eik", "initials": "EE"}, {"family": "Torp Kristensen", "given": "Andreas", "initials": "A", "orcid": "0000-0002-4570-236X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d7e7db4d0ce4167a4ea31c1da5df461.json"}}, {"family": "Juul", "given": "Sophie", "initials": "S", "orcid": "0000-0002-6171-2904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76a1c669d07f4d559ae43063bb008b68.json"}}, {"family": "Holgersson", "given": "Johan", "initials": "J"}, {"family": "Nielsen", "given": "Niklas", "initials": "N"}, {"family": "Bentzer", "given": "Peter", "initials": "P"}, {"family": "Thabane", "given": "Lehana", "initials": "L", "orcid": "0000-0003-0355-9734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/499ab3d178774eaa9f6a44345dbf6a7c.json"}}, {"family": "Kwasi Korang", "given": "Steven", "initials": "S"}, {"family": "Klingenberg", "given": "Sarah", "initials": "S"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Jakobsen", "given": "Janus C", "initials": "JC"}], "type": "journal article", "published": "2023-06-20", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "6", "pages": "e064498"}, "abstract": "To assess the effects of interventions authorised by the European Medicines Agency (EMA) or the US Food and Drug Administration (FDA) for prevention of COVID-19 progression to severe disease in outpatients.\r\n\r\nOutpatient treatment.\r\n\r\nParticipants with a diagnosis of COVID-19 and the associated SARS-CoV-2 virus irrespective of age, sex and comorbidities.\r\n\r\nDrug interventions authorised by EMA or FDA.\r\n\r\nPrimary outcomes were all-cause mortality and serious adverse events.\r\n\r\nWe included 17 clinical trials randomising 16 257 participants to 8 different interventions authorised by EMA or FDA. 15/17 of the included trials (88.2%) were assessed at high risk of bias. Only molnupiravir and ritonavir-boosted nirmatrelvir seemed to improve both our primary outcomes. Meta-analyses showed that molnupiravir reduced the risk of death (relative risk (RR) 0.11, 95% CI 0.02 to 0.64; p=0.0145, 2 trials; very low certainty of evidence) and serious adverse events (RR 0.63, 95% CI 0.47 to 0.84; p=0.0018, 5 trials; very low certainty of evidence). Fisher's exact test showed that ritonavir-boosted nirmatrelvir reduced the risk of death (p=0.0002, 1 trial; very low certainty of evidence) and serious adverse events (p<0.0001, 1 trial; very low certainty of evidence) in 1 trial including 2246 patients, while another trial including 1140 patients reported 0 deaths in both groups.\r\n\r\nThe certainty of the evidence was very low, but, from the results of this study, molnupiravir showed the most consistent benefit and ranked highest among the approved interventions for prevention of COVID-19 progression to severe disease in outpatients. The lack of certain evidence should be considered when treating patients with COVID-19 for prevention of disease progression.\r\n\r\nCRD42020178787.", "doi": "10.1136/bmjopen-2022-064498", "pmid": "37339844", "labels": {"Category: Health": null, "Funder: VR": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10314423"}, {"db": "pii", "key": "bmjopen-2022-064498"}], "notes": [], "created": "2023-10-04T09:30:26.060Z", "modified": "2023-10-04T09:54:58.635Z"}, {"entity": "publication", "iuid": "f6cb2deed35b47a0a02ae2df7677df9f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6cb2deed35b47a0a02ae2df7677df9f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6cb2deed35b47a0a02ae2df7677df9f"}}, "title": "Diagnostic Usefulness of Spiroergometry and Risk Factors of Long COVID in Patients with Normal Left Ventricular Ejection Fraction.", "authors": [{"family": "Gryglewska-Wawrzak", "given": "Katarzyna", "initials": "K", "orcid": "0000-0001-7902-3042", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4d37e0f556244848e36712615c66efa.json"}}, {"family": "Sakowicz", "given": "Agata", "initials": "A", "orcid": "0000-0002-5083-2046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2ce71c0e6664383a44c8cc4cb61fcf3.json"}}, {"family": "Banach", "given": "Maciej", "initials": "M", "orcid": "0000-0001-6690-6874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/904a6969b0e244adb21ded395af3ac1a.json"}}, {"family": "Byty\u00e7i", "given": "Ibadete", "initials": "I", "orcid": "0000-0002-8996-4257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba2f218876104573a8e529b1c2b6f671.json"}}, {"family": "Bielecka-Dabrowa", "given": "Agata", "initials": "A", "orcid": "0000-0001-6666-3999", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b7cdcb731104a908bca628cd8b338e6.json"}}], "type": "journal article", "published": "2023-06-20", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "12", "issue": "12", "pages": null}, "abstract": "The emergence of the Coronavirus Disease 2019 (COVID-19) pandemic has brought forth various clinical manifestations and long-term complications, including a condition known as long COVID. Long COVID refers to a persistent set of symptoms that continue beyond the acute phase of the disease. This study investigated the risk factors and the utility of spiroergometry parameters for diagnosing patients with long COVID symptoms. The 146 patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with normal left ventricular ejection fraction and without respiratory diseases were included and divided into two groups: the group demonstrating long COVID symptoms [n = 44] and the group without long COVID symptoms [n = 102]. The clinical examinations, laboratory test results, echocardiography, non-invasive body mass analysis, and spiroergometry were evaluated. ClinicalTrials.gov Identifier: NCT04828629. Patients with long COVID symptoms had significantly higher age [58 (vs.) 44 years; p < 0.0001], metabolic age [53 vs. 45 years; p = 0.02)], left atrial diameter (LA) [37 vs. 35 mm; p = 0.04], left ventricular mass index (LVMI) [83 vs. 74 g/m2, p = 0.04], left diastolic filling velocity (A) [69 vs. 64 cm/s, p = 0.01], the ratio of peak velocity of early diastolic transmitral flow to peak velocity of early diastolic mitral annular motion (E/E') [7.35 vs. 6.05; p = 0.01], and a lower ratio of early to late diastolic transmitral flow velocity (E/A) [1.05 vs. 1.31; p = 0.01] compared to the control group. In cardiopulmonary exercise testing (CPET), long COVID patients presented lower forced vital capacity (FVC) [3.6 vs. 4.3 L; p < 0.0001], maximal oxygen consumption measured during incremental exercise indexed per kilogram (VO2max) [21 vs. 23 mL/min/kg; p = 0.04], respiratory exchange ratio (RER) [1.0 vs. 1.1; p = 0.04], forced expiratory volume in one second (FEV1) [2.90 vs. 3.25 L; p = 0.04], and a higher ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC%) [106 vs. 100%; p = 0.0002]. The laboratory results pointed out that patients with long COVID symptoms also had a lower rate of red blood cells (RBC) [4.4 vs. 4.6 \u00d7 106/uL; p = 0.01]; a higher level of glucose [92 vs. 90 mg/dL; p = 0.03]; a lower glomerular filtration rate (GFR) estimate by Modification of Diet in Renal Disease (MDRD) [88 vs. 95; p = 0.03]; and a higher level of hypersensitive cardiac Troponin T (hs-cTnT) [6.1 vs. 3.9 pg/mL; p = 0.04]. On the multivariate model, only FEV1/FVC% (OR 6.27, 95% CI: 2.64-14.86; p < 0.001) independently predicted the long COVID symptoms. Using the ROC analysis, the FEV1/FVC% \u2265 103 was the most powerful predictor of spiroergometry parameters (0.67 sensitive, 0.71 specific, AUC of 0.73; p < 0.001) in predicting the symptoms of long COVID. Spiroergometry parameters are useful in diagnosing long COVID and differentiating it from cardiovascular disease.", "doi": "10.3390/jcm12124160", "pmid": "37373853", "labels": {"Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10299442"}, {"db": "pii", "key": "jcm12124160"}, {"db": "ClinicalTrials.gov", "key": "NCT04828629"}], "notes": [], "created": "2023-10-04T09:32:51.948Z", "modified": "2023-10-04T11:13:26.785Z"}, {"entity": "publication", "iuid": "c7021304f6614e1aa11f020c15d29276", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7021304f6614e1aa11f020c15d29276.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7021304f6614e1aa11f020c15d29276"}}, "title": "Artificial intelligence-driven prediction of COVID-19-related hospitalization and death: a systematic review.", "authors": [{"family": "Shakibfar", "given": "Saeed", "initials": "S"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Zhao", "given": "Jing", "initials": "J"}, {"family": "Nordeng", "given": "Hedvig Marie Egeland", "initials": "HME"}, {"family": "Sandve", "given": "Geir Kjetil Ferkingstad", "initials": "GKF"}, {"family": "Pavlovic", "given": "Milena", "initials": "M"}, {"family": "Hajiebrahimi", "given": "Mohammadhossein", "initials": "M"}, {"family": "Andersen", "given": "Morten", "initials": "M"}, {"family": "Sessa", "given": "Maurizio", "initials": "M"}], "type": "systematic review", "published": "2023-06-20", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "1183725"}, "abstract": "To perform a systematic review on the use of Artificial Intelligence (AI) techniques for predicting COVID-19 hospitalization and mortality using primary and secondary data sources.\r\n\r\nCohort, clinical trials, meta-analyses, and observational studies investigating COVID-19 hospitalization or mortality using artificial intelligence techniques were eligible. Articles without a full text available in the English language were excluded.\r\n\r\nArticles recorded in Ovid MEDLINE from 01/01/2019 to 22/08/2022 were screened.\r\n\r\nWe extracted information on data sources, AI models, and epidemiological aspects of retrieved studies.\r\n\r\nA bias assessment of AI models was done using PROBAST.\r\n\r\nPatients tested positive for COVID-19.\r\n\r\nWe included 39 studies related to AI-based prediction of hospitalization and death related to COVID-19. The articles were published in the period 2019-2022, and mostly used Random Forest as the model with the best performance. AI models were trained using cohorts of individuals sampled from populations of European and non-European countries, mostly with cohort sample size <5,000. Data collection generally included information on demographics, clinical records, laboratory results, and pharmacological treatments (i.e., high-dimensional datasets). In most studies, the models were internally validated with cross-validation, but the majority of studies lacked external validation and calibration. Covariates were not prioritized using ensemble approaches in most of the studies, however, models still showed moderately good performances with Area under the Receiver operating characteristic Curve (AUC) values >0.7. According to the assessment with PROBAST, all models had a high risk of bias and/or concern regarding applicability.\r\n\r\nA broad range of AI techniques have been used to predict COVID-19 hospitalization and mortality. The studies reported good prediction performance of AI models, however, high risk of bias and/or concern regarding applicability were detected.", "doi": "10.3389/fpubh.2023.1183725", "pmid": "37408750", "labels": {"Funder: Forte": null, "Category: Public Health": null, "Category: Other": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: KAW/SciLifeLab": null, "Type: Review": null, "Funder: NordForsk": null}, "xrefs": [{"db": "pmc", "key": "PMC10319067"}], "notes": [], "created": "2023-10-04T12:09:35.195Z", "modified": "2023-10-04T12:57:56.322Z"}, {"entity": "publication", "iuid": "5ab564d97000495aac9c28ce671845c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5ab564d97000495aac9c28ce671845c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5ab564d97000495aac9c28ce671845c9"}}, "title": "Experiences of aftermath of COVID-19 in relation to social, financial and health related aspects among previously hospitalized patients: a qualitative exploration.", "authors": [{"family": "Nandonik", "given": "Ahmed Jojan", "initials": "AJ"}, {"family": "Das Pooja", "given": "Shangjucta", "initials": "S"}, {"family": "Ahmed", "given": "Tanvir", "initials": "T"}, {"family": "Parvez", "given": "Anwar", "initials": "A"}, {"family": "Kabir", "given": "Zarina Nahar", "initials": "ZN"}], "type": "journal article", "published": "2023-06-15", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "1196810"}, "abstract": "There is increasing evidence of long-term consequences of COVID-19. The world has seen multidimensional impact of the pandemic and Bangladesh is no exception to that. Policymakers in Bangladesh laid out strategies to curb the initial spread of COVID-19. However, long-term consequences of COVID-19 received little or no attention in the country. Evidence suggests that people presumed to be recovered face multidimensional post-covid consequences. This study aimed to describe the aftermath of COVID-19 in relation to social, financial and health related aspects among previously hospitalized patients.\r\n\r\nThis descriptive qualitative study includes participants (n = 14) who were previously hospitalized for COVID-19 and returned home after recovery. The participants were part of a mixed method study from which they were purposively selected. Semi-structured in-depth interviews were conducted over telephone. Inductive content analysis was used to analyze the data.\r\n\r\nTwelve sub-categories emerged from the data analysis which converged into five main categories. The main categories included perspective on physical health, financial struggle, life adjustment, interplay between different domains, and spontaneous support.\r\n\r\nThe lived experiences of COVID-19 recovered patients highlighted multidimensional impact on their daily lives. Physical and psychological wellbeing found to be related to the effort of restoring financial status. People's perception about life altered due to pandemic, for few the pandemic was an opportunity to grow while others found it difficult to accept the hardship. Such multidimensional post COVID-19 impact on people's lives and wellbeing holds considerable implication for response and mitigation plan for future related pandemics.", "doi": "10.3389/fpubh.2023.1196810", "pmid": "37397755", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10311015"}], "notes": [], "created": "2023-10-04T12:08:58.334Z", "modified": "2023-10-04T12:45:46.487Z"}, {"entity": "publication", "iuid": "d881e0269eb546b5b9f6e7afe681a3ea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d881e0269eb546b5b9f6e7afe681a3ea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d881e0269eb546b5b9f6e7afe681a3ea"}}, "title": "Effects of the COVID-19 pandemic on mental health, working, and life situation of employees in the Swedish hospitality industry.", "authors": [{"family": "Feltmann", "given": "Kristin", "initials": "K"}, {"family": "Gustafsson", "given": "Nina-Katri J", "initials": "NJ"}, {"family": "Elg\u00e1n", "given": "Tobias H", "initials": "TH"}, {"family": "Gripenberg", "given": "Johanna", "initials": "J"}, {"family": "Kvillemo", "given": "Pia", "initials": "P"}], "type": "journal article", "published": "2023-06-14", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "1178847"}, "abstract": "Previous studies reported that the coronavirus disease (COVID-19) pandemic has negatively affected the mental health of employees in the hospitality industry internationally, however, its effect in Sweden has not been studied. Unlike several other countries, Sweden never enforced a lockdown. Restaurants, bars, and hotels could remain open and host a limited number of guests but had to abide by certain restrictions.\r\n\r\nA cross-sectional survey was distributed among hospitality industry employees containing questions regarding the perceived effects of the pandemic on the respondents' working and life situations and their physical and psychological health. The sample consisted of 699 individuals, with a response rate of 47.9%.\r\n\r\nAlthough several respondents had been laid off or furloughed, the majority of the sample remained at the same employer. However, more than half of the respondents reported that their economic situation had deteriorated. Compared to before the pandemic, 38.1% experienced elevated levels of stress, 48.3% experienced elevated levels of worry, and 31.4% reported worsened mood. A deteriorating personal economy and difficulty in following COVID-19-related restrictions at work were associated with the worsening of these three mental health aspects. While the fear of becoming infected with COVID-19 was related to higher levels of stress, the fear of infecting others was related to higher levels of worry.\r\n\r\nAlthough Sweden imposed less strict measures than most other countries, the personal economy and mental health of hospitality workers were negatively affected by the COVID-19 pandemic.", "doi": "10.3389/fpubh.2023.1178847", "pmid": "37388155", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10303113"}], "notes": [], "created": "2023-10-04T09:31:14.241Z", "modified": "2023-10-04T10:46:13.914Z"}, {"entity": "publication", "iuid": "35e61dc5b20249189443661e0e8d32db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/35e61dc5b20249189443661e0e8d32db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/35e61dc5b20249189443661e0e8d32db"}}, "title": "Disrupting the opportunity narrative: navigating transformation in times of uncertainty and crisis.", "authors": [{"family": "Moore", "given": "Michele-Lee", "initials": "M"}, {"family": "Hermanus", "given": "Lauren", "initials": "L"}, {"family": "Drimie", "given": "Scott", "initials": "S"}, {"family": "Rose", "given": "Loretta", "initials": "L"}, {"family": "Mbaligontsi", "given": "Mandisa", "initials": "M"}, {"family": "Musarurwa", "given": "Hillary", "initials": "H"}, {"family": "Ogutu", "given": "Moses", "initials": "M"}, {"family": "Oyowe", "given": "Khanyisa", "initials": "K"}, {"family": "Olsson", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2023-06-14", "journal": {"title": "Sustain Sci", "issn": "1862-4057", "issn-l": null, "volume": null, "issue": null, "pages": "1-17"}, "abstract": "COVID-19 posed threats for health and well-being directly, but it also revealed and exacerbated social-ecological inequalities, worsening hunger and poverty for millions. For those focused on transforming complex and problematic system dynamics, the question was whether such devastation could create a formative moment in which transformative change could become possible. Our study examines the experiences of change agents in six African countries engaged in efforts to create or support transformative change processes. To better understand the relationship between crisis, agency, and transformation, we explored how they navigated their changed conditions and the responses to COVID-19. We document three impacts: economic impacts, hunger, and gender-based violence and we examine how they (re)shaped the opportunity contexts for change. Finally, we identify four kinds of uncertainties that emerged as a result of policy responses, including uncertainty about the: (1) robustness of preparing a system to sustain a transformative trajectory, (2) sequencing and scaling of changes within and across systems, (3) hesitancy and exhaustion effects, and (4) long-term effects of surveillance, and we describe the associated change agent strategies. We suggest these uncertainties represent new theoretical ground for future transformations research.\r\n\r\nThe online version contains supplementary material available at 10.1007/s11625-023-01340-1.", "doi": "10.1007/s11625-023-01340-1", "pmid": "37363311", "labels": {"Category: Social Science & Humanities": null, "Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10265562"}, {"db": "pii", "key": "1340"}], "notes": [], "created": "2023-10-04T09:32:21.466Z", "modified": "2023-10-04T11:05:44.341Z"}, {"entity": "publication", "iuid": "6bfd31e9905e445fac42bbb935e9d426", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6bfd31e9905e445fac42bbb935e9d426.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6bfd31e9905e445fac42bbb935e9d426"}}, "title": "Behavioral responses of terrestrial mammals to COVID-19 lockdowns.", "authors": [{"family": "Tucker", "given": "Marlee A", "initials": "MA", "orcid": "0000-0001-7535-3431", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39e654d94797463893f3590bb779d056.json"}}, {"family": "Schipper", "given": "Aafke M", "initials": "AM", "orcid": "0000-0002-5667-0893", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68a75c2ed9924c70897ac6947592c335.json"}}, {"family": "Adams", "given": "Tempe S F", "initials": "TSF"}, {"family": "Attias", "given": "Nina", "initials": "N", "orcid": "0000-0002-9472-6763", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f703ab61b3364654b989cbcc3ed99ce2.json"}}, {"family": "Avgar", "given": "Tal", "initials": "T", "orcid": "0000-0002-8764-6976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8428fb8febb44f49f6cd4abbe4bd61f.json"}}, {"family": "Babic", "given": "Natarsha L", "initials": "NL", "orcid": "0000-0001-6813-9728", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c49b0167d18344f9802d241103a8fa72.json"}}, {"family": "Barker", "given": "Kristin J", "initials": "KJ", "orcid": "0000-0002-1618-7610", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bea5c2a78de34997ab5af9c72359b8ef.json"}}, {"family": "Bastille-Rousseau", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-6799-639X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f1001971c674ae79e6a0b72d5842310.json"}}, {"family": "Behr", "given": "Dominik M", "initials": "DM", "orcid": "0000-0001-7378-8538", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b035004e8f4048c581b6fe5df098c93f.json"}}, {"family": "Belant", "given": "Jerrold L", "initials": "JL"}, {"family": "Beyer", "given": "Dean E", "initials": "DE"}, {"family": "Blaum", "given": "Niels", "initials": "N", "orcid": "0000-0001-6807-5162", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3550ab0cc47b489bb0dddcac51db8563.json"}}, {"family": "Blount", "given": "J David", "initials": "JD", "orcid": "0000-0003-3208-2947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b6367bd4df5545a5ba9ed2a6a53b8ae9.json"}}, {"family": "Bockm\u00fchl", "given": "Dirk", "initials": "D"}, {"family": "Pires Boulhosa", "given": "Ricardo Luiz", "initials": "RL", "orcid": "0000-0002-1212-7805", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c6aaa32848b482ab3e9b18bfda7900b.json"}}, {"family": "Brown", "given": "Michael B", "initials": "MB", "orcid": "0000-0002-0119-0614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a0d7860afa14b10a1a1862aa39c3cfa.json"}}, {"family": "Buuveibaatar", "given": "Bayarbaatar", "initials": "B", "orcid": "0000-0003-0404-269X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd145213190b4541b84fd34417aba1bc.json"}}, {"family": "Cagnacci", "given": "Francesca", "initials": "F", "orcid": "0000-0002-4954-9980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d05696a8933422b8b9b1cde6acb9ac4.json"}}, {"family": "Calabrese", "given": "Justin M", "initials": "JM", "orcid": "0000-0003-0575-6408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67d44f10243745e680172193412492e6.json"}}, {"family": "\u010cerne", "given": "Rok", "initials": "R"}, {"family": "Chamaill\u00e9-Jammes", "given": "Simon", "initials": "S", "orcid": "0000-0003-0505-6620", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4b1216168fc4acd89859a2f7f684faf.json"}}, {"family": "Chan", "given": "Aung Nyein", "initials": "AN", "orcid": "0000-0003-2706-6969", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc84aeda43b540ca84aa81780998ede3.json"}}, {"family": "Chase", "given": "Michael J", "initials": "MJ"}, {"family": "Chaval", "given": "Yannick", "initials": "Y"}, {"family": "Chenaux-Ibrahim", "given": "Yvette", "initials": "Y", "orcid": "0000-0002-7239-9108", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d264598b4f04e77ba0f6c4c98c9e296.json"}}, {"family": "Cherry", "given": "Seth G", "initials": "SG", "orcid": "0000-0003-4242-3629", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6338b3468954b26a4bb6426e6f34346.json"}}, {"family": "\u0106irovi\u0107", "given": "Du\u0161ko", "initials": "D", "orcid": "0000-0001-9468-0948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0997b4f72b3a4cf9b7aa79f20fc2b94e.json"}}, {"family": "\u00c7oban", "given": "Emrah", "initials": "E", "orcid": "0000-0002-9020-2014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1bdeb742f2c48d689e7a13db719b348.json"}}, {"family": "Cole", "given": "Eric K", "initials": "EK", "orcid": "0000-0002-2229-5853", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56e3c4fab7a24dc282847a7010660ca5.json"}}, {"family": "Conlee", "given": "Laura", "initials": "L"}, {"family": "Courtemanch", "given": "Alyson", "initials": "A", "orcid": "0000-0001-7405-7657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b93b87aca8a4b07bfce2915c7afaca4.json"}}, {"family": "Cozzi", "given": "Gabriele", "initials": "G", "orcid": "0000-0002-1744-1940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/468af7bfd1d84ecf9f093421b6e17125.json"}}, {"family": "Davidson", "given": "Sarah C", "initials": "SC", "orcid": "0000-0002-2766-9201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4104be953f3d4f82829883993dc311ae.json"}}, {"family": "DeBloois", "given": "Darren", "initials": "D", "orcid": "0000-0002-5960-0524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/029508ab21c440c9b8623be18da70807.json"}}, {"family": "Dejid", "given": "Nandintsetseg", "initials": "N", "orcid": "0000-0002-5376-3808", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d78e716ee1849c8bac3885e9ddb70a1.json"}}, {"family": "DeNicola", "given": "Vickie", "initials": "V", "orcid": "0000-0003-3558-2541", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa24a0c2330f4f70859ecc45a8898e49.json"}}, {"family": "Desbiez", "given": "Arnaud L J", "initials": "ALJ", "orcid": "0000-0001-5968-6025", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f83ef1c96e74a208e032b68ee33e5cd.json"}}, {"family": "Douglas-Hamilton", "given": "Iain", "initials": "I", "orcid": "0000-0002-7942-7554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c5c3b38ed2c4109887974d48265babc.json"}}, {"family": "Drake", "given": "David", "initials": "D"}, {"family": "Egan", "given": "Michael", "initials": "M"}, {"family": "Eikelboom", "given": "Jasper A J", "initials": "JAJ", "orcid": "0000-0002-5107-4427", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/783112dcb8fa440a8a7f1dc395436670.json"}}, {"family": "Fagan", "given": "William F", "initials": "WF", "orcid": "0000-0003-2433-9052", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9c9b1c4511b42829a6bdc819f83d2b6.json"}}, {"family": "Farmer", "given": "Morgan J", "initials": "MJ", "orcid": "0000-0002-6320-9587", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7762aff3c005490e9817f6d31f8cc708.json"}}, {"family": "Fennessy", "given": "Julian", "initials": "J", "orcid": "0000-0001-5871-8267", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28050549c3f04a328cba87965d802b01.json"}}, {"family": "Finnegan", "given": "Shannon P", "initials": "SP", "orcid": "0000-0003-3265-9996", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/138a7e1b278441eb84bc1ce3bc0821e3.json"}}, {"family": "Fleming", "given": "Christen H", "initials": "CH", "orcid": "0000-0002-9356-6518", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9119e001684465aaab71a752ab721fb.json"}}, {"family": "Fournier", "given": "Bonnie", "initials": "B"}, {"family": "Fowler", "given": "Nicholas L", "initials": "NL", "orcid": "0000-0003-3977-0945", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b18a5ccfac24095ad4df1d65fd8b7bb.json"}}, {"family": "Gantchoff", "given": "Mariela G", "initials": "MG", "orcid": "0000-0002-7098-8072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42810228f6c4465f93b8775e3592a31c.json"}}, {"family": "Garnier", "given": "Alexandre", "initials": "A", "orcid": "0000-0003-3515-8556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc98ff203d0e490394a489f2e31f238b.json"}}, {"family": "Gehr", "given": "Benedikt", "initials": "B", "orcid": "0000-0002-1044-9296", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42fea1cd196a4c72a3e3e78b12e06054.json"}}, {"family": "Geremia", "given": "Chris", "initials": "C"}, {"family": "Goheen", "given": "Jacob R", "initials": "JR", "orcid": "0000-0001-6609-0692", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e21fbd5ccba45ee92e12d568b3ff7fb.json"}}, {"family": "Hauptfleisch", "given": "Morgan L", "initials": "ML", "orcid": "0000-0003-0654-0887", "researcher": {"href": 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"Stewart", "given": "Cheyenne", "initials": "C", "orcid": "0000-0003-3394-1926", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44af4cd029dd44a5b962ef5f0532a610.json"}}, {"family": "Strand", "given": "Olav", "initials": "O"}, {"family": "Sunde", "given": "Peter", "initials": "P", "orcid": "0000-0002-7485-037X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6aeaa45baa1c49be961015b46e902313.json"}}, {"family": "Svoboda", "given": "Nathan J", "initials": "NJ", "orcid": "0000-0002-1939-0569", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81a560acb4194666bd618a4d4d73447a.json"}}, {"family": "Swart", "given": "Jonathan", "initials": "J"}, {"family": "Thompson", "given": "Jeffrey J", "initials": "JJ", "orcid": "0000-0002-5632-1466", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a51bc818b4874660ba0ef67ab54e0312.json"}}, {"family": "Toal", "given": "Katrina L", "initials": "KL"}, {"family": "Uiseb", "given": "Kenneth", "initials": "K", "orcid": "0000-0002-5284-9917", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/16d9082540ad420390d2d9ffd6387c14.json"}}, {"family": "VanAcker", "given": "Meredith C", "initials": "MC", "orcid": "0000-0002-5690-9139", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80932eb728274c65aad725e335addd82.json"}}, {"family": "Velilla", "given": "Marianela", "initials": "M", "orcid": "0000-0002-4212-885X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73a5e56198c746428c55e6eb008ba0a7.json"}}, {"family": "Verzuh", "given": "Tana L", "initials": "TL", "orcid": "0000-0003-4027-5415", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2758992cbdfb413cbd74a836ed38c0bc.json"}}, {"family": "Wachter", "given": "Bettina", "initials": "B", "orcid": "0000-0002-0414-2298", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa93e479797847b7aa92596fa42abca3.json"}}, {"family": "Wagler", "given": "Brittany L", "initials": "BL", "orcid": "0000-0001-9526-820X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b18fb21a5f64401da1c860eac6b18e7e.json"}}, {"family": "Whittington", "given": "Jesse", "initials": "J", "orcid": "0000-0002-4129-7491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1fd61d870e474140acfa1a4c94f7d6a6.json"}}, {"family": "Wikelski", "given": "Martin", "initials": "M", "orcid": "0000-0002-9790-7025", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c024723549c485886b238320b8d2df5.json"}}, {"family": "Wilmers", "given": "Christopher C", "initials": "CC", "orcid": "0000-0003-2063-1478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7bbb1a449b9c47c1ba23cbe52421f41d.json"}}, {"family": "Wittemyer", "given": "George", "initials": "G", "orcid": "0000-0003-1640-5355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a34151a7cae947678b526d0729dfb35b.json"}}, {"family": "Young", "given": "Julie K", "initials": "JK", "orcid": "0000-0003-4522-0157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/978312c400d244298994c1ff848de78b.json"}}, {"family": "Zi\u0119ba", "given": "Filip", "initials": "F"}, {"family": "Zwijacz-Kozica", "given": "Tomasz", "initials": "T", "orcid": "0000-0002-7488-975X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a7eb67e79544a04b42db4c701fb9966.json"}}, {"family": "Huijbregts", "given": "Mark A J", "initials": "MAJ", "orcid": "0000-0002-7037-680X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/292dab5a2730421f806d017d8c048708.json"}}, {"family": "Mueller", "given": "Thomas", "initials": "T", "orcid": "0000-0001-9305-7716", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a8409fac8db41ca8b1ae9b4bd129a8a.json"}}], "type": "journal article", "published": "2023-06-09", "journal": {"title": "Science", "issn": "1095-9203", "issn-l": "0036-8075", "volume": "380", "issue": "6649", "pages": "1059-1064"}, "abstract": "COVID-19 lockdowns in early 2020 reduced human mobility, providing an opportunity to disentangle its effects on animals from those of landscape modifications. Using GPS data, we compared movements and road avoidance of 2300 terrestrial mammals (43 species) during the lockdowns to the same period in 2019. Individual responses were variable with no change in average movements or road avoidance behavior, likely due to variable lockdown conditions. However, under strict lockdowns 10-day 95th percentile displacements increased by 73%, suggesting increased landscape permeability. Animals' 1-hour 95th percentile displacements declined by 12% and animals were 36% closer to roads in areas of high human footprint, indicating reduced avoidance during lockdowns. Overall, lockdowns rapidly altered some spatial behaviors, highlighting variable but substantial impacts of human mobility on wildlife worldwide.", "doi": "10.1126/science.abo6499", "pmid": "37289888", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:32:57.916Z", "modified": "2023-10-04T11:15:23.800Z"}, {"entity": "publication", "iuid": "2e7edc9ebbdc404690076ca003d8d320", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e7edc9ebbdc404690076ca003d8d320.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e7edc9ebbdc404690076ca003d8d320"}}, "title": "Challenges in preserving the \"good doctor\" norm: physicians' discourses on changes to the medical logic during the initial wave of the COVID-19 pandemic.", "authors": [{"family": "H\u00e4rgestam", "given": "Maria", "initials": "M"}, {"family": "Jacobsson", "given": "Maritha", "initials": "M"}, {"family": "B\u00e5\u00e5the", "given": "Fredrik", "initials": "F"}, {"family": "Brulin", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2023-06-08", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "14", "issue": null, "pages": "1083047"}, "abstract": "The COVID-19 pandemic was a tremendous challenge to the practice of modern medicine. In this study, we use neo-institutional theory to gain an in-depth understanding of how physicians in Sweden narrate how they position themselves as physicians when practicing modern medicine during the first wave of the pandemic. At focus is medical logic, which integrates rules and routines based on medical evidence, practical experience, and patient perspectives in clinical decision-making.\r\n\r\nTo understand how physicians construct their versions of the pandemic and how it impacted the medical logic in which they practice, we analyzed the interviews from 28 physicians in Sweden by discursive psychology.\r\n\r\nThe interpretative repertoires showed how COVID-19 created an experience of knowledge vacuum in medical logic and how physicians dealt with clinical patient dilemmas. They had to find unorthodox ways to rebuild a sense of medical evidence while still being responsible for clinical decision-making for patients with critical care needs.\r\n\r\nIn the knowledge vacuum occurring during the first wave of COVID-19, physicians could not use their common medical knowledge nor rely on published evidence or their clinical judgment. They were thus challenged in their norm of being the \"good doctor\". One practical implication of this research is that it provides a rich empirical account where physicians are allowed to mirror, make sense, and normalize their own individual and sometimes painful struggle to uphold the professional role and related medical responsibility in the early phases of the COVID-19 pandemic. It will be important to follow how the tremendous challenge of COVID-19 to medical logic plays out over time in the community of physicians. There are many dimensions to study, with sick leave, burnout, and attrition being some interesting areas.", "doi": "10.3389/fpsyg.2023.1083047", "pmid": "37359864", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Funder: Forte": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10285475"}], "notes": [], "created": "2023-10-04T09:31:01.174Z", "modified": "2023-10-04T10:40:57.789Z"}, {"entity": "publication", "iuid": "197891042362460798eb43322d0e99aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/197891042362460798eb43322d0e99aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/197891042362460798eb43322d0e99aa"}}, "title": "The increasing age of respiratory syncytial virus-related hospitalisation during COVID-19 pandemic in Lyon was associated with reduced hospitalisation costs.", "authors": [{"family": "Roy", "given": "\u00c1lvaro", "initials": "\u00c1"}, {"family": "Polazzi", "given": "St\u00e9phanie", "initials": "S"}, {"family": "Ploin", "given": "Dominique", "initials": "D"}, {"family": "Gillet", "given": "Yves", "initials": "Y"}, {"family": "Javouhey", "given": "Etienne", "initials": "E"}, {"family": "Lina", "given": "Bruno", "initials": "B"}, {"family": "VRS study group in Lyon", "given": "", "initials": ""}, {"family": "Myard-Dury", "given": "Anne-Florence", "initials": "A"}, {"family": "Couray-Targe", "given": "Sandrine", "initials": "S"}, {"family": "Duclos", "given": "Antoine", "initials": "A"}, {"family": "Casalegno", "given": "Jean-S\u00e9bastien", "initials": "J"}], "type": "journal article", "published": "2023-06-07", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null, "volume": "41", "issue": "25", "pages": "3796-3800"}, "abstract": "Preventive measures applied during the COVID-19 pandemic have modified the age distribution, the clinical severity and the incidence of Respiratory Syncytial Virus (RSV) hospitalisations during the 2020/21 RSV season. The aim of the present study was to estimate the impact of these aspects on RSV-associated hospitalisations (RSVH) costs stratified by age group between pre-COVID-19 seasons and 2020/21 RSV season.\r\n\r\nWe compared the incidence, the median costs, and total RSVH costs from the national health insurance perspective in children < 24 months of age during the COVID-19 period (2020/21 RSV season) with a pre-COVID-19 period (2014/17 RSV seasons). Children were born and hospitalised in the Lyon metropolitan area. RSVH costs were extracted from the French medical information system (Programme de M\u00e9dicalisation des Syst\u00e9mes d'Information).\r\n\r\nThe RSVH-incidence rate per 1000 infants aged < 3 months decreased significantly from 4.6 (95 % CI [4.1; 5.2]) to 3.1 (95 % CI [2.4; 4.0]), and increased in older infants and children up to 24 months of age during the 2020/21 RSV season. Overall, RSVH costs for RSVH cases aged below 2 years old decreased by \u20ac201,770 (31 %) during 2020/21 RSV season compared to the mean pre-COVID-19 costs.\r\n\r\nThe sharp reduction in costs of RSVH in infants aged < 3 months outweighed the modest increase in costs observed in the 3-24 months age group. Therefore, conferring a temporal protection through passive immunisation to infants aged < 3 months should have a major impact on RSVH costs even if it results in an increase of RSVH in older children infected later in life. Nevertheless, stakeholders should be aware of this potential increase of RSVH in older age groups presenting with a wider range of disease to avoid any bias in estimating the cost-effectiveness of passive immunisation strategies.", "doi": "10.1016/j.vaccine.2023.05.021", "pmid": "37198017", "labels": {"Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10169568"}, {"db": "pii", "key": "S0264-410X(23)00548-0"}], "notes": [], "created": "2023-10-04T05:11:05.684Z", "modified": "2023-10-04T07:06:48.858Z"}, {"entity": "publication", "iuid": "71bc203ffa044fe28ec637a7c3070875", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/71bc203ffa044fe28ec637a7c3070875.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/71bc203ffa044fe28ec637a7c3070875"}}, "title": "Hindering and enabling factors for young employees with common mental disorder to remain at or return to work affected by the Covid-19 pandemic - a qualitative interview study with young employees and managers.", "authors": [{"family": "Wallberg", "given": "Martina", "initials": "M", "orcid": "0000-0002-8881-1822", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9349fb21e752467c85bd602c36510a91.json"}}, {"family": "Tinnerholm Ljungberg", "given": "Helena", "initials": "H"}, {"family": "Bj\u00f6rk Br\u00e4mberg", "given": "Elisabeth", "initials": "E"}, {"family": "Nybergh", "given": "Lotta", "initials": "L"}, {"family": "Jensen", "given": "Irene", "initials": "I"}, {"family": "Olsson", "given": "Caroline", "initials": "C", "orcid": "0000-0001-7561-2480", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/38563e81bb7d4ec794d7798fed320161.json"}}], "type": "journal article", "published": "2023-06-07", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "6", "pages": "e0286819"}, "abstract": "During the COVID-19 pandemic, changes in working life occurred, even in Sweden, where there was no general lockdown. The aim of this study was to examine how the COVID-19 pandemic was perceived as affecting the hindering and enabling factors among young employees with CMD to remain at or return to work, here as investigated from the perspective of young employees and managers.\r\n\r\nA qualitative design was applied with semistructured interviews with 23 managers and 25 young employees (20-29 years old). The interviews were recorded and transcribed verbatim, and the parts of the interviews related to the aim of this article were analysed using conventional content analysis.\r\n\r\nThe hindering factors were changed working conditions, decreased well-being when spending more time at home, and uncertainty. The enabling factors were decreased demands, increased balance, and well-functioning work processes. For managers it is important to be aware of warning signals indicating blurred boundaries between work and private life, to create and maintain well-functioning communication, and leave room for recovery.\r\n\r\nThe hindering and enabling factors can be described as two sides of the same coin. Changes in the working conditions during the pandemic led to difficulties for both young employees and managers when the margins of maneuver were insufficient.", "doi": "10.1371/journal.pone.0286819", "pmid": "37285347", "labels": {"Category: Social Science & Humanities": null, "Funder: Forte": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10246792"}, {"db": "pii", "key": "PONE-D-22-17806"}], "notes": [], "created": "2023-10-04T09:31:53.412Z", "modified": "2023-10-04T10:57:11.810Z"}, {"entity": "publication", "iuid": "34746c67d2384baa9e428ac6d9b6ad2c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/34746c67d2384baa9e428ac6d9b6ad2c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/34746c67d2384baa9e428ac6d9b6ad2c"}}, "title": "COVID-19 hospitalization outcomes in adults by HIV status; a nation-wide register-based study.", "authors": [{"family": "M\u00f6ller", "given": "Isabela Killander", "initials": "IK", "orcid": "0000-0002-4105-2902", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3278886cd2af47229149a55443b38f09.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Wagner", "given": "Philippe", "initials": "P"}, {"family": "Spar\u00e9n", "given": "P\u00e4r", "initials": "P"}, {"family": "Carlander", "given": "Christina", "initials": "C", "orcid": "0000-0001-9962-5964", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b819f761acf34fdea8f11d0743a5b86c.json"}}], "type": "journal article", "published": "2023-06-07", "journal": {"title": "HIV Med", "issn": "1468-1293", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To assess the outcome of patients hospitalized with COVID-19 by HIV status and risk factors for severe COVID-19 in people living with HIV (PWH), we performed a nationwide cohort study using register data.\r\n\r\nAll people aged \u226518 years hospitalized with a primary COVID-19 diagnosis (U07.1 or U07.2) in Sweden between February 2020 and October 2021 were included. The primary outcome was severe COVID-19 [intensive care unit (ICU) admission or 90-day mortality]. Secondary outcomes were days in hospital and ICU, complications in hospital, and risk factors for severe COVID-19 in PWH. Regression analyses were performed to assess severe COVID-19 by HIV status and risk factors.\r\n\r\nData from 64 815 hospitalized patients were collected, of whom 121 were PWH (0.18%). PWH were younger (p < 0.001), and larger proportions were men (p = 0.014) and migrants (p < 0.001). Almost all PWH had undetectable HIV-RNA (93%) and high CD4 T-cell counts (median = 560 cells/\u03bcL, interquartile range: 376-780). In an unadjusted model, PWH had statistically significant lower odds of severe COVID-19 compared with patients without HIV [odds ratio (OR) = 0.6, 95% confidence interval (CI): 0.34-0.94], but there was no significant difference after adjusting for age and comorbidity (adjusted OR = 0.7, 95% CI: 0.43-1.26). A statistically significant lower proportion of PWH (8%, 95% CI: 5-15%) died within 90 days compared with those without HIV (16%, 95% CI: 15-16%, p = 0.024). There was no statistically significant difference in days in hospital and complications during the hospital stay between PWH and patients without HIV.\r\n\r\nIn this nationwide study including well-treated PWH, HIV was not a risk factor in hospitalized patients for developing severe COVID-19.", "doi": "10.1111/hiv.13515", "pmid": "37286199", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:30:33.798Z", "modified": "2023-10-04T09:58:23.498Z"}, {"entity": "publication", "iuid": "f12410c233584d12a1290f24ac6cac03", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f12410c233584d12a1290f24ac6cac03.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f12410c233584d12a1290f24ac6cac03"}}, "title": "Functional Foods: A Promising Strategy for Restoring Gut Microbiota Diversity Impacted by SARS-CoV-2 Variants.", "authors": [{"family": "Banerjee", "given": "Antara", "initials": "A"}, {"family": "Somasundaram", "given": "Indumathi", "initials": "I"}, {"family": "Das", "given": "Diptimayee", "initials": "D"}, {"family": "Jain Manoj", "given": "Samatha", "initials": "S"}, {"family": "Banu", "given": "Husaina", "initials": "H"}, {"family": "Mitta Suresh", "given": "Pavane", "initials": "P"}, {"family": "Paul", "given": "Sujay", "initials": "S", "orcid": "0000-0001-5024-7261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1c15a587da6470ea73c6e3c29a4ba6b.json"}}, {"family": "Bisgin", "given": "Atil", "initials": "A", "orcid": "0000-0002-2053-9076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13bfbc623c634b269c7c69fbb303254d.json"}}, {"family": "Zhang", "given": "Hong", "initials": "H", "orcid": "0000-0003-1834-1578", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/85be136845f6469c946e000f38f18f28.json"}}, {"family": "Sun", "given": "Xiao-Feng", "initials": "X"}, {"family": "Duttaroy", "given": "Asim K", "initials": "AK", "orcid": "0000-0003-1619-3778", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/464702978fa64a368987901580720fe8.json"}}, {"family": "Pathak", "given": "Surajit", "initials": "S", "orcid": "0000-0002-7306-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2cfa7af2c5c549cc82d6f407b1e1e56b.json"}}], "type": "journal article", "published": "2023-06-05", "journal": {"title": "Nutrients", "issn": "2072-6643", "issn-l": null, "volume": "15", "issue": "11", "pages": null}, "abstract": "Natural herbs and functional foods contain bioactive molecules capable of augmenting the immune system and mediating anti-viral functions. Functional foods, such as prebiotics, probiotics, and dietary fibers, have been shown to have positive effects on gut microbiota diversity and immune function. The use of functional foods has been linked to enhanced immunity, regeneration, improved cognitive function, maintenance of gut microbiota, and significant improvement in overall health. The gut microbiota plays a critical role in maintaining overall health and immune function, and disruptions to its balance have been linked to various health problems. SARS-CoV-2 infection has been shown to affect gut microbiota diversity, and the emergence of variants poses new challenges to combat the virus. SARS-CoV-2 recognizes and infects human cells through ACE2 receptors prevalent in lung and gut epithelial cells. Humans are prone to SARS-CoV-2 infection because their respiratory and gastrointestinal tracts are rich in microbial diversity and contain high levels of ACE2 and TMPRSS2. This review article explores the potential use of functional foods in mitigating the impact of SARS-CoV-2 variants on gut microbiota diversity, and the potential use of functional foods as a strategy to combat these effects.", "doi": "10.3390/nu15112631", "pmid": "37299594", "labels": {"Category: Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC10255361"}, {"db": "pii", "key": "nu15112631"}], "notes": [], "created": "2023-10-04T09:32:23.905Z", "modified": "2023-10-04T11:06:54.692Z"}, {"entity": "publication", "iuid": "e0284c17d08b406b99333dcc60d91f37", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e0284c17d08b406b99333dcc60d91f37.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e0284c17d08b406b99333dcc60d91f37"}}, "title": "Coronavirus disease 2019 and gastrointestinal disorders in children.", "authors": [{"family": "R\u00f6ckert Tjernberg", "given": "Anna", "initials": "A", "orcid": "0000-0001-8126-9738", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14df79dd609a4ec1baa8dfda5d7826c7.json"}}, {"family": "Malmborg", "given": "Petter", "initials": "P"}, {"family": "M\u00e5rild", "given": "Karl", "initials": "K"}], "type": "journal article", "published": "2023-06-05", "journal": {"title": "Therap Adv Gastroenterol", "issn": "1756-283X", "issn-l": null, "volume": "16", "issue": null, "pages": "17562848231177612"}, "abstract": "During the past 3 years, the coronavirus disease 2019 (COVID-19) pandemic has had a great impact on people all over the world. However, it has become evident that disease manifestations and severity differ across age groups. Most children have a milder disease course than adults but possibly more pronounced gastrointestinal (GI) symptoms. Given the child's developing immune system, the impact of COVID-19 on disease development may differ compared to adults. This study reviews the potential bi-directional relationship between COVID-19 and GI diseases in children, focusing on common pediatric conditions such as functional GI disorders (FGID), celiac disease (CeD), and inflammatory bowel disease (IBD). Children with GI diseases, in general, and CeD and IBD, in particular, do not seem to have an increased risk of severe COVID-19, including risks of hospitalization, critical care need, and death. While infections are considered candidate environmental factors in both CeD and IBD pathogenesis, and specific infectious agents are known triggers for FGID, there is still not sufficient evidence to implicate COVID-19 in the development of either of these diseases. However, given the scarcity of data and the possible latency period between environmental triggers and disease development, future investigations in this field are warranted.", "doi": "10.1177/17562848231177612", "pmid": "37305380", "labels": {"Category: Health": null, "Funder: VR": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10243097"}, {"db": "pii", "key": "10.1177_17562848231177612"}], "notes": [], "created": "2023-10-04T09:30:39.172Z", "modified": "2023-10-04T10:00:22.818Z"}, {"entity": "publication", "iuid": "b681fae3e4244f0481cfe1fcd6f88761", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b681fae3e4244f0481cfe1fcd6f88761.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b681fae3e4244f0481cfe1fcd6f88761"}}, "title": "Psychiatric and non-psychiatric population vulnerabilities in time of a crisis: the unsuspected aggression factor.", "authors": [{"family": "Martin", "given": "Sylvia", "initials": "S"}, {"family": "Oltra", "given": "Anna", "initials": "A"}, {"family": "Del Monte", "given": "Jonathan", "initials": "J"}], "type": "journal article", "published": "2023-06-01", "journal": {"title": "BMC Psychiatry", "issn": "1471-244X", "issn-l": null, "volume": "23", "issue": "1", "pages": "386"}, "abstract": "In March 2020, France faced a health crisis due to the COVID-19 outbreak that, like previous infectious disease crises, involved high psychological and emotional stress, a series of factors that influenced the ongoing mental health crisis.\r\n\r\nWe recruited 384 respondents to complete an online questionnaire during the second month of isolation: 176 psychotherapy recipients (68 were currently attending psychiatric care) and 208 healthy controls. We measured demographic characteristics, impulsivity, aggression, hopelessness, suicidal risk, and the global level of anxiety and depression in order to estimate potential discrepancies in clinical measures across these populations.\r\n\r\nOur results indicate that the group currently undergoing psychiatric care was prone to loneliness and social isolation. Regarding clinical and nonclinical population, there were differences in suicidal risk, depression, anxiety, and hopelessness but mainly in aggression. Regression analysis also demonstrated that aggression surprisingly influenced anxiety levels. Patients undergoing therapy compared with patients who were not displayed differences only in suicidal risk, anxiety, and hopelessness, with those undergoing therapy having higher scores. The outpatient group undergoing therapy had a significantly lower level of impulsivity. Moreover, the regression to predict anxiety and depression levels from correlated factors highlighted the potentially heightened role of aggression in predicting anxiety in the clinical group.\r\n\r\nNew research into stress reactions should assess other clinical signals, such as aggression, and examine preventive mental health interventions in times of crisis.", "doi": "10.1186/s12888-023-04843-4", "pmid": "37264352", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10234249"}, {"db": "pii", "key": "10.1186/s12888-023-04843-4"}], "notes": [], "created": "2023-10-04T09:32:55.523Z", "modified": "2023-10-04T11:14:18.576Z"}, {"entity": "publication", "iuid": "41efdcff61bd4f449f244b6fd78cd47a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41efdcff61bd4f449f244b6fd78cd47a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41efdcff61bd4f449f244b6fd78cd47a"}}, "title": "Assessing the availability and quality of COVID-19 mortality data in Europe: a comparative analysis.", "authors": [{"family": "Marinkovi\u0107", "given": "Ivan", "initials": "I"}, {"family": "Tramo\u0161ljanin", "given": "Ana", "initials": "A"}, {"family": "Galjak", "given": "Marko", "initials": "M", "orcid": "0000-0002-1756-3083", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13cc17cd42d04f39a19c9c844b825f12.json"}}], "type": "journal article", "published": "2023-06-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": null, "issue": null, "pages": null}, "abstract": "Researching mortality during the COVID-19 pandemic has been challenging due to methodological inconsistencies and the limited availability of vital statistics data. At the beginning of the pandemic, the World Health Organization recommended daily data publication to inform policy response, but these data were often poor. Final data on COVID-19 deaths in many countries are not yet available, especially for 2021. This report shows that many countries have significant inconsistencies between the preliminary number of deaths and what vital statistics and excess mortality indicate. The inconsistencies in the mortality data raise concerns about the reliability of analyses and public health recommendations.", "doi": "10.1093/eurpub/ckad088", "pmid": "37263603", "labels": {"Category: Other": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7188269"}], "notes": [], "created": "2023-10-04T09:31:16.503Z", "modified": "2023-10-04T10:47:07.312Z"}, {"entity": "publication", "iuid": "adc405a737f54f5b931af68fc3b891ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/adc405a737f54f5b931af68fc3b891ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/adc405a737f54f5b931af68fc3b891ae"}}, "title": "Age and sex differences in cause-specific excess mortality and years of life lost associated with COVID-19 infection in the Swedish population.", "authors": [{"family": "Lundberg", "given": "Christina E", "initials": "CE", "orcid": "0000-0002-9062-9982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8800d9296bee40f9b178e8ab8399a993.json"}}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}, {"family": "Brand\u00e9n", "given": "Maria", "initials": "M"}, {"family": "Cronie", "given": "Ottmar", "initials": "O"}, {"family": "Lindgren", "given": "Martin", "initials": "M"}, {"family": "Edqvist", "given": "Jon", "initials": "J"}, {"family": "\u00c5berg", "given": "Maria", "initials": "M"}, {"family": "Adiels", "given": "Martin", "initials": "M"}, {"family": "Rosengren", "given": "Annika", "initials": "A", "orcid": "0000-0002-5409-6605", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9cd943e45dd14e14b5367c0ad1a2b950.json"}}], "type": "journal article", "published": "2023-06-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": null, "issue": null, "pages": null}, "abstract": "Estimating excess mortality and years of life lost (YLL) attributed to coronavirus disease 19 (COVID-19) infection provides a comprehensive picture of the mortality burden on society. We aimed to estimate the impact of the COVID-19 pandemic on age- and sex-specific excess mortality and YLL in Sweden during the first 17 months of the pandemic.\r\n\r\nIn this population-based observational study, we calculated age- and sex-specific excess all-cause mortality and excess YLL during 2020 and the first 5 months of 2021 and cause-specific death [deaths from cardiovascular disease (CVD), cancer, other causes and deaths excluding COVID-19] in 2020 compared with an average baseline for 2017-19 in the whole Swedish population.\r\n\r\nCOVID-19 deaths contributed 9.9% of total deaths (98 441 deaths, 960 305 YLL) in 2020, accounting for 75 151 YLL (7.7 YLL/death). There were 2672 (5.7%) and 1408 (3.0%) excess deaths, and 19 141 (3.8%) and 3596 (0.8%) excess YLL in men and women, respectively. Men aged 65-110 years and women aged 75-110 years were the greatest contributors. Fewer deaths and YLL from CVD, cancer and other causes were observed in 2020 compared with the baseline adjusted to the population size in 2020.\r\n\r\nCompared with the baseline, excess mortality and YLL from all causes were experienced in Sweden during 2020, with a higher excess observed in men than in women, indicating that more men died at a younger age while more women died at older ages than expected. A notable reduction in deaths and YLL due to CVD suggests a displacement effect from CVD to COVID-19.", "doi": "10.1093/eurpub/ckad086", "pmid": "37263601", "labels": {"Category: Health": null, "Funder: VR": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7188268"}], "notes": [], "created": "2023-10-04T09:30:43.855Z", "modified": "2023-10-04T10:02:39.508Z"}, {"entity": "publication", "iuid": "c45d86d4b8694925aaa296723ab7423f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c45d86d4b8694925aaa296723ab7423f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c45d86d4b8694925aaa296723ab7423f"}}, "title": "The macroeconomics of pandemics around the world: Lives versus livelihoods revisited.", "authors": [{"family": "Alm\u00e5s", "given": "Ingvild", "initials": "I"}, {"family": "Bold", "given": "Tessa", "initials": "T"}, {"family": "von Carnap", "given": "Tillmann", "initials": "T"}, {"family": "Ghisolfi", "given": "Selene", "initials": "S"}, {"family": "Sandefur", "given": "Justin", "initials": "J"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "J Dev Econ", "issn": "0304-3878", "issn-l": null, "volume": "163", "issue": null, "pages": "103099"}, "abstract": "The COVID-19 pandemic led governments around the world to impose unprecedented restrictions on economic activity. Were these restrictions equally justified in poorer countries with fewer demographic risk factors and less ability to weather economic shocks? We develop and estimate a fully specified model of the macroeconomy with epidemiological dynamics, incorporating subsistence constraints in consumption and allowing preferences over \"lives versus livelihoods\" to vary with income. Poorer countries' demography pushes them unambiguously toward laxer policies. But because both infected and susceptible agents near the subsistence constraint will remain economically active in the face of infection risk and even to some extent under government containment policies, optimal policy in poorer countries pushes in the opposite direction. Moreover, for reasonable income-elasticities of the value of a statistical life, the model can fully rationalize equally strict or stricter policies in poorer countries.", "doi": "10.1016/j.jdeveco.2023.103099", "pmid": "37151749", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10102539"}, {"db": "pii", "key": "S0304-3878(23)00054-8"}], "notes": [], "created": "2023-10-04T05:12:09.277Z", "modified": "2023-10-04T07:30:00.817Z"}, {"entity": "publication", "iuid": "3b523ea9895b42db95bb6286ef80952b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b523ea9895b42db95bb6286ef80952b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b523ea9895b42db95bb6286ef80952b"}}, "title": "The IHI Rochester Report 2022 on Healthcare Informatics Research: Resuming After the CoViD-19.", "authors": [{"family": "Combi", "given": "Carlo", "initials": "C"}, {"family": "Facelli", "given": "Julio C", "initials": "JC"}, {"family": "Haddawy", "given": "Peter", "initials": "P"}, {"family": "Holmes", "given": "John H", "initials": "JH"}, {"family": "Koch", "given": "Sabine", "initials": "S"}, {"family": "Liu", "given": "Hongfang", "initials": "H"}, {"family": "Meyer", "given": "Jochen", "initials": "J"}, {"family": "Peleg", "given": "Mor", "initials": "M"}, {"family": "Pozzi", "given": "Giuseppe", "initials": "G"}, {"family": "Stiglic", "given": "Gregor", "initials": "G"}, {"family": "Veltri", "given": "Pierangelo", "initials": "P"}, {"family": "Yang", "given": "Christopher C", "initials": "CC"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "J Healthc Inform Res", "issn": "2509-4971", "issn-l": null, "volume": "7", "issue": "2", "pages": "169-202"}, "abstract": "In 2020, the CoViD-19 pandemic spread worldwide in an unexpected way and suddenly modified many life issues, including social habits, social relationships, teaching modalities, and more. Such changes were also observable in many different healthcare and medical contexts. Moreover, the CoViD-19 pandemic acted as a stress test for many research endeavors, and revealed some limitations, especially in contexts where research results had an immediate impact on the social and healthcare habits of millions of people. As a result, the research community is called to perform a deep analysis of the steps already taken, and to re-think steps for the near and far future to capitalize on the lessons learned due to the pandemic. In this direction, on June 09th-11th, 2022, a group of twelve healthcare informatics researchers met in Rochester, MN, USA. This meeting was initiated by the Institute for Healthcare Informatics-IHI, and hosted by the Mayo Clinic. The goal of the meeting was to discuss and propose a research agenda for biomedical and health informatics for the next decade, in light of the changes and the lessons learned from the CoViD-19 pandemic. This article reports the main topics discussed and the conclusions reached. The intended readers of this paper, besides the biomedical and health informatics research community, are all those stakeholders in academia, industry, and government, who could benefit from the new research findings in biomedical and health informatics research. Indeed, research directions and social and policy implications are the main focus of the research agenda we propose, according to three levels: the care of individuals, the healthcare system view, and the population view.", "doi": "10.1007/s41666-023-00126-5", "pmid": "37359193", "labels": {"Funder: H2020": null, "Type: Other": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10150351"}, {"db": "pii", "key": "126"}], "notes": [], "created": "2023-10-04T09:32:16.624Z", "modified": "2023-10-04T11:01:01.548Z"}, {"entity": "publication", "iuid": "caa0cd6c9f3c41b49d6c8db447f9de06", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/caa0cd6c9f3c41b49d6c8db447f9de06.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/caa0cd6c9f3c41b49d6c8db447f9de06"}}, "title": "New urban habits in Stockholm following COVID-19.", "authors": [{"family": "Legeby", "given": "Ann", "initials": "A", "orcid": "0000-0002-3173-853X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cbe1819ded8340b7a9712da118ce8c12.json"}}, {"family": "Koch", "given": "Daniel", "initials": "D"}, {"family": "Duarte", "given": "F\u00e1bio", "initials": "F", "orcid": "0000-0003-0909-5379", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/527c769b3b2143e99e126eb2af7ecd4e.json"}}, {"family": "Heine", "given": "Cate", "initials": "C"}, {"family": "Benson", "given": "Tom", "initials": "T"}, {"family": "Fugiglando", "given": "Umberto", "initials": "U", "orcid": "0000-0001-6527-8968", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05008e7f430d4dccbe1e060d65ba9178.json"}}, {"family": "Ratti", "given": "Carlo", "initials": "C"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Urban Stud", "issn": "0042-0980", "issn-l": null, "volume": "60", "issue": "8", "pages": "1448-1464"}, "abstract": "During the COVID-19 pandemic, physical distancing, mobility restrictions and self-isolation measures were implemented around the world as the primary intervention to prevent the virus from spreading. Urban life has undergone sweeping changes, with people using spaces in new ways. Stockholm is a particularly relevant case of this phenomenon since most facilities, such as day care centres and schools, have remained open, in contrast to cities with a broader lockdown. In this study, we use Twitter data and an online map survey to study how COVID-19 restrictions have impacted the use of different locations, services and amenities in Stockholm. First, we compare the spatial distribution of 87,000 geolocated tweets pre-COVID-19 and during the COVID-19 pandemic. Second, we analyse 895 survey responses asking people to identify places they 'still visit', 'use more', 'avoid' and self-report reasons for using locations. The survey provides a nuanced understanding of whether and how restrictions have affected people. Service and seclusion were found to be important; therefore, the accessibility of such amenities was analysed, demonstrating how changes in urban habits are related to conditions of the local environment. We find how different parts of the city show different capacities to accommodate new habits and mitigate the effects of restrictions on people's use of urban spaces. In addition to the immediate relevance to COVID-19, this paper thus contributes to understanding how restrictions on movement and gathering, in any situation, expose more profound urban challenges related to segregation and social inequality.", "doi": "10.1177/00420980211070677", "pmid": "37273493", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10230291"}, {"db": "pii", "key": "10.1177_00420980211070677"}], "notes": [], "created": "2023-10-04T09:32:39.460Z", "modified": "2023-10-04T11:12:45.336Z"}, {"entity": "publication", "iuid": "1ef151bcb5714f42a000050ed3c43b52", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ef151bcb5714f42a000050ed3c43b52.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ef151bcb5714f42a000050ed3c43b52"}}, "title": "Leisure mobility changes during the COVID-19 pandemic - An analysis of survey and mobile phone data in Sweden.", "authors": [{"family": "\u00d6sth", "given": "John", "initials": "J"}, {"family": "Toger", "given": "Marina", "initials": "M"}, {"family": "T\u00fcrk", "given": "Umut", "initials": "U"}, {"family": "Kourtit", "given": "Karima", "initials": "K"}, {"family": "Nijkamp", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Res Transp Bus Manag", "issn": "2210-5409", "issn-l": null, "volume": "48", "issue": null, "pages": "100952"}, "abstract": "The COVID-19 pandemic affected travelling in general, and the leisure mobility and the spatial distribution of travellers in particular. In most parts of the world, both domestic and international travel has been replaced by restrictive policies and recommendations on mobility. A modal shift from public transport towards private cars and micro-mobility was also observed. This study seeks to trace the implications of the COVID-19 pandemic for leisure mobility. We use a unique Swedish database containing daily mobility patterns of pseudonymised mobile phone users, combined with a survey on vacation transport behaviour. By contrasting mobility patterns for selected holiday days during the unaffected summer of 2019 with corresponding dates in 2020 and 2021, we are able to model and detect the pandemic effects on tourism and recreational mobility. Moreover, by identifying the general mobility patterns, we analyse whether and how the transport mode has changed. Using data on the spatial distribution of recreational amenities, we identify locations that were favoured during the pandemic. In Sweden, even though the pandemic decreased in spread and severity during the summers, most travel restrictions were still enforced, international vacations uncommon, and larger vacation spots, such as amusement parks and cultural institutions, were closed down. Swedish vacation homes in remote or rural areas were quickly booked. This change in recreational behaviour, where less populated areas, open air and nature recreation were favoured over indoor or crowded urban cultural activities, was more substantial in 2021 than in 2020. This result shows how policies can effectively be developed, so that Swedes respond properly to recommendations and adjust their vacation plans.", "doi": "10.1016/j.rtbm.2023.100952", "pmid": "38013673", "labels": {"Funder: H2020": null, "Category: Social Science & Humanities": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9884620"}, {"db": "pii", "key": "S2210-5395(23)00008-1"}], "notes": [], "created": "2023-12-04T07:22:14.078Z", "modified": "2023-12-08T06:09:30.755Z"}, {"entity": "publication", "iuid": "46fc0cdf480a4887a1989d1e245cf463", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46fc0cdf480a4887a1989d1e245cf463.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46fc0cdf480a4887a1989d1e245cf463"}}, "title": "Job loss and job instability during the COVID-19 pandemic and the risk of depression and anxiety among Swedish employees.", "authors": [{"family": "Blomqvist", "given": "Sandra", "initials": "S"}, {"family": "H\u00f6gn\u00e4s", "given": "Robin S", "initials": "RS"}, {"family": "Virtanen", "given": "Marianna", "initials": "M"}, {"family": "LaMontagne", "given": "Anthony D", "initials": "AD"}, {"family": "Magnusson Hanson", "given": "Linda L", "initials": "LL"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "SSM Popul Health", "issn": "2352-8273", "issn-l": null, "volume": "22", "issue": null, "pages": "101424"}, "abstract": "The COVID-19 pandemic led to permanent and temporary job losses but the mental health consequences of different types of employment transitions are not well-understood. In particular, knowledge is scarce concerning furloughs, which was a common job protection strategy in many high- and upper middle-income countries during this crisis. This study focuses on how different types of job instability and job loss during the pandemic influences depression and anxiety in the context of Sweden. A subset of participants from the Swedish Longitudinal Occupational Survey of Health were contacted in February 2021 and again in February 2022. A total of 1558 individuals participated in either or both waves and worked before the pandemic. We examined whether i) workplace downsizing, ii) furlough, or iii) unemployment/job loss were associated with depression and anxiety over this one-year period during the pandemic. Logistic regression models with cluster-robust standard errors were estimated, adjusting for sociodemographic factors and prior mental health problems. Effect modification by sex and prior mental health problems was also examined. In comparison to stable employment, being furloughed was unrelated to mental health, while experiencing workplace downsizing during the pandemic was associated with an increased risk of anxiety (adjusted Odds Ratio (OR) = 2.09, 95% Confidence interval (CI) = 1.08-4.05). Job loss/unemployment increased the risk of depression (OR = 1.91, 95% CI = 1.02-3.57) compared to being stably employed, but the risk estimate crossed unity when considering prior mental health status. No effect modification by sex or by prior mental health problems was found. This study found that while job loss and downsizing during the COVID-19 pandemic were associated with depression and anxiety, respectively, being furloughed was not. These findings thus suggest that job retention schemes in the form of short-time work allowances, as implemented in Sweden during the COVID-19 pandemic, may prevent mental health problems among employees during economic crises.", "doi": "10.1016/j.ssmph.2023.101424", "pmid": "37159634", "labels": {"Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10158169"}, {"db": "pii", "key": "S2352-8273(23)00089-7"}], "notes": [], "created": "2023-10-04T05:11:24.229Z", "modified": "2023-10-04T07:11:22.409Z"}, {"entity": "publication", "iuid": "4456be75b63f4527b96167b7ef4a4631", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4456be75b63f4527b96167b7ef4a4631.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4456be75b63f4527b96167b7ef4a4631"}}, "title": "In vitro high-content tissue models to address precision medicine challenges.", "authors": [{"family": "Afewerki", "given": "Samson", "initials": "S"}, {"family": "Stocco", "given": "Thiago Domingues", "initials": "TD"}, {"family": "Rosa da Silva", "given": "Andr\u00e9 Diniz", "initials": "AD"}, {"family": "Aguiar Furtado", "given": "Andr\u00e9 Sales", "initials": "AS"}, {"family": "Fernandes de Sousa", "given": "Gustavo", "initials": "G"}, {"family": "Ruiz-Esparza", "given": "Guillermo U", "initials": "GU"}, {"family": "Webster", "given": "Thomas J", "initials": "TJ"}, {"family": "Marciano", "given": "Fernanda R", "initials": "FR"}, {"family": "Str\u00f8mme", "given": "Maria", "initials": "M"}, {"family": "Zhang", "given": "Yu Shrike", "initials": "YS", "orcid": "0000-0002-0045-0808", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a7c59d189474a49a590ae7fcb4f294d.json"}}, {"family": "Lobo", "given": "Anderson Oliveira", "initials": "AO"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Mol Aspects Med", "issn": "1872-9452", "pages": "101108", "volume": "91", "issn-l": null}, "abstract": "The field of precision medicine allows for tailor-made treatments specific to a patient and thereby improve the efficiency and accuracy of disease prevention, diagnosis, and treatment and at the same time would reduce the cost, redundant treatment, and side effects of current treatments. Here, the combination of organ-on-a-chip and bioprinting into engineering high-content in vitro tissue models is envisioned to address some precision medicine challenges. This strategy could be employed to tackle the current coronavirus disease 2019 (COVID-19), which has made a significant impact and paradigm shift in our society. Nevertheless, despite that vaccines against COVID-19 have been successfully developed and vaccination programs are already being deployed worldwide, it will likely require some time before it is available to everyone. Furthermore, there are still some uncertainties and lack of a full understanding of the virus as demonstrated in the high number new mutations arising worldwide and reinfections of already vaccinated individuals. To this end, efficient diagnostic tools and treatments are still urgently needed. In this context, the convergence of bioprinting and organ-on-a-chip technologies, either used alone or in combination, could possibly function as a prominent tool in addressing the current pandemic. This could enable facile advances of important tools, diagnostics, and better physiologically representative in vitro models specific to individuals allowing for faster and more accurate screening of therapeutics evaluating their efficacy and toxicity. This review will cover such technological advances and highlight what is needed for the field to mature for tackling the various needs for current and future pandemics as well as their relevancy towards precision medicine.", "doi": "10.1016/j.mam.2022.101108", "pmid": "35987701", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9384546"}, {"db": "pii", "key": "S0098-2997(22)00053-X"}], "notes": [], "created": "2022-09-12T18:48:08.519Z", "modified": "2023-06-19T15:33:47.094Z"}, {"entity": "publication", "iuid": "7bcff8cad7644b8080abab3d4e51f599", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7bcff8cad7644b8080abab3d4e51f599.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7bcff8cad7644b8080abab3d4e51f599"}}, "title": "High Prevalence of SARS-CoV-2 Omicron Infection Despite High Seroprevalence, Sweden, 2022.", "authors": [{"family": "Groenheit", "given": "Ramona", "initials": "R"}, {"family": "Bacchus", "given": "Philip", "initials": "P"}, {"family": "Galanis", "given": "Ilias", "initials": "I"}, {"family": "Sond\u00e9n", "given": "Klara", "initials": "K"}, {"family": "Bujila", "given": "Ioana", "initials": "I"}, {"family": "Efimova", "given": "Tatiana", "initials": "T"}, {"family": "Garli", "given": "Fredrik", "initials": "F"}, {"family": "Lindsj\u00f6", "given": "Oskar Karlsson", "initials": "OK"}, {"family": "Mansj\u00f6", "given": "Mikael", "initials": "M"}, {"family": "Movert", "given": "Elin", "initials": "E"}, {"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Rapp", "given": "Marie", "initials": "M"}, {"family": "Sperk", "given": "Maike", "initials": "M"}, {"family": "S\u00f6derholm", "given": "Sandra", "initials": "S"}, {"family": "Asin", "given": "Karin Valentin", "initials": "KV"}, {"family": "Zanetti", "given": "Sarah", "initials": "S"}, {"family": "Karlberg", "given": "Maria Lind", "initials": "ML"}, {"family": "Br\u00e5ve", "given": "Andreas", "initials": "A"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Emerg Infect Dis", "issn": "1080-6059", "volume": "29", "issue": "6", "pages": "1240-1243", "issn-l": null}, "abstract": "We performed 2 surveys during 2022 to estimate point prevalences of SARS-CoV-2 infection compared with overall seroprevalence in Sweden. Point prevalence was 1.4% in March and 1.5% in September. Estimated seroprevalence was >80%, including among unvaccinated children. Continued SARS-CoV-2 surveillance is necessary for detecting emerging, possibly more pathogenic variants.", "doi": "10.3201/eid2906.221862", "pmid": "37141616", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10202879"}], "notes": [], "created": "2023-07-13T11:37:13.361Z", "modified": "2023-07-13T11:37:13.365Z"}, {"entity": "publication", "iuid": "6336bc6ca2c14794b41168651fdfdaf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6336bc6ca2c14794b41168651fdfdaf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6336bc6ca2c14794b41168651fdfdaf3"}}, "title": "Establishing severe acute respiratory infection (SARI) surveillance in a sentinel hospital, Ireland, 2021 to 2022.", "authors": [{"family": "Brady", "given": "Melissa", "initials": "M"}, {"family": "Duffy", "given": "Roisin", "initials": "R"}, {"family": "Domegan", "given": "Lisa", "initials": "L"}, {"family": "Salmon", "given": "Abigail", "initials": "A"}, {"family": "Maharjan", "given": "Binita", "initials": "B"}, {"family": "O'Broin", "given": "Cathal", "initials": "C"}, {"family": "Bennett", "given": "Charlene", "initials": "C"}, {"family": "Christle", "given": "James", "initials": "J"}, {"family": "Connell", "given": "Jeff", "initials": "J"}, {"family": "Feeney", "given": "Laura", "initials": "L"}, {"family": "Nurdin", "given": "Nadra", "initials": "N"}, {"family": "Mallon", "given": "Patrick", "initials": "P"}, {"family": "Doran", "given": "Peter", "initials": "P"}, {"family": "McNamara", "given": "Rosa", "initials": "R"}, {"family": "O'Grady", "given": "Sarah", "initials": "S"}, {"family": "McDermott", "given": "Sinead", "initials": "S"}, {"family": "Petty-Saphon", "given": "Naomi", "initials": "N"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "23", "pages": null}, "abstract": "BackgroundIn 2020, due to the COVID-19 pandemic, the European Centre for Disease Prevention and Control (ECDC) accelerated development of European-level severe acute respiratory infection (SARI) surveillance.AimWe aimed to establish SARI surveillance in one Irish hospital as part of a European network E-SARI-NET.MethodsWe used routine emergency department records to identify cases in one adult acute hospital. The SARI case definition was adapted from the ECDC clinical criteria for a possible COVID-19 case. Clinical data were collected using an online questionnaire. Cases were tested for SARS-CoV-2, influenza and respiratory syncytial virus (RSV), including whole genome sequencing (WGS) on SARS-CoV-2 RNA-positive samples and viral characterisation/sequencing on influenza RNA-positive samples. Descriptive analysis was conducted for SARI cases hospitalised between July 2021 and April 2022.ResultsOverall, we identified 437 SARI cases, the incidence ranged from two to 28 cases per week (0.7-9.2/100,000 hospital catchment population). Of 431 cases tested for SARS-CoV-2 RNA, 226 (52%) were positive. Of 349 (80%) cases tested for influenza and RSV RNA, 15 (4.3%) were positive for influenza and eight (2.3%) for RSV. Using WGS, we identified Delta- and Omicron-dominant periods. The resource-intensive nature of manual clinical data collection, specimen management and laboratory supply shortages for influenza and RSV testing were challenging.ConclusionWe successfully established SARI surveillance as part of E-SARI-NET. Expansion to additional sentinel sites is planned following formal evaluation of the existing system. SARI surveillance requires multidisciplinary collaboration, automated data collection where possible, and dedicated personnel resources, including for specimen management.", "doi": "10.2807/1560-7917.ES.2023.28.23.2200740", "pmid": "37289427", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10318943"}], "notes": [], "created": "2023-10-04T09:30:04.862Z", "modified": "2023-10-04T09:47:34.315Z"}, {"entity": "publication", "iuid": "99d71e90a9a64e30a3fdf43372df352c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/99d71e90a9a64e30a3fdf43372df352c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/99d71e90a9a64e30a3fdf43372df352c"}}, "title": "Differences in incidence, nature of symptoms, and duration of long COVID among hospitalised migrant and non-migrant patients in the Netherlands: a retrospective cohort study.", "authors": [{"family": "Chilunga", "given": "Felix Patience", "initials": "FP"}, {"family": "Appelman", "given": "Brent", "initials": "B"}, {"family": "van Vugt", "given": "Michele", "initials": "M"}, {"family": "Kalverda", "given": "Kirsten", "initials": "K"}, {"family": "Smeele", "given": "Patrick", "initials": "P"}, {"family": "van Es", "given": "Josien", "initials": "J"}, {"family": "Wiersinga", "given": "Willem Joost", "initials": "WJ"}, {"family": "Rostila", "given": "Mikael", "initials": "M"}, {"family": "Prins", "given": "Maria", "initials": "M"}, {"family": "Stronks", "given": "Karien", "initials": "K"}, {"family": "Norredam", "given": "Marie", "initials": "M"}, {"family": "Agyemang", "given": "Charles", "initials": "C"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "issn-l": null, "volume": "29", "issue": null, "pages": "100630"}, "abstract": "Comprehensive data on long COVID across ethnic and migrant groups are lacking. We investigated incidence, nature of symptoms, clinical predictors, and duration of long COVID among COVID-19 hospitalised patients in the Netherlands by migration background (Dutch, Turkish, Moroccan, and Surinamese origin, Others).\r\n\r\nWe used COVID-19 admissions and follow up data (January 2021-July 2022) from Amsterdam University Medical Centers. We calculated long COVID incidence proportions per NICE guidelines by migration background and assessed for clinical predictors via robust Poisson regressions. We then examined associations between migration background and long COVID using robust Poisson regressions and adjusted for derived clinical predictors, and other biologically relevant factors. We also assessed long COVID symptom persistence at one-year post-discharge.\r\n\r\n1886 patients were included. 483 patients had long COVID (26%, 95% CI 24-28%) at 12 weeks post-discharge. Symptoms like dizziness, joint pain, insomnia, and headache varied by migration background. Clinical predictors of long COVID were female sex, hospital admission duration, intensive care unit admission, and receiving oxygen, or corticosteroid therapy. Long COVID risk was higher among patients with migration background than Dutch origin patients after adjustments for derived clinical predictors, age, smoking, vaccination status, comorbidities and remdesivir treatment. Only 14% of long COVID symptoms persisted at one-year post-discharge.\r\n\r\nThere are significant differences in occurrence, nature of symptoms, and duration of long COVID by migration background. Studies assessing the spectrum of functional limitation and access to post-COVID healthcare are needed to help plan for appropriate and accessible healthcare interventions.\r\n\r\nThe Amsterdam UMC COVID-19 biobank is supported by the Amsterdam UMC Corona Research Fund and the Talud Foundation (Stichting Talud). The current analyses were supported by the Novo Nordisk Foundation [NNF21OC0067528].", "doi": "10.1016/j.lanepe.2023.100630", "pmid": "37261215", "labels": {"Category: Post-COVID": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10079482"}, {"db": "pii", "key": "S2666-7762(23)00049-2"}], "notes": [], "created": "2023-10-04T09:32:34.156Z", "modified": "2023-10-04T11:11:02.084Z"}, {"entity": "publication", "iuid": "611d3dec80a4496989e28b0aad6ac03d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/611d3dec80a4496989e28b0aad6ac03d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/611d3dec80a4496989e28b0aad6ac03d"}}, "title": "COVID-19 infection in patients on long-term home parenteral nutrition for chronic intestinal failure.", "authors": [{"family": "Pironi", "given": "Loris", "initials": "L"}, {"family": "Jezerski", "given": "Denise", "initials": "D"}, {"family": "Sobocki", "given": "Jacek", "initials": "J"}, {"family": "Lal", "given": "Simon", "initials": "S"}, {"family": "Vanuytsel", "given": "Tim", "initials": "T"}, {"family": "Theilla", "given": "Miriam", "initials": "M"}, {"family": "Sasdelli", "given": "Anna S", "initials": "AS"}, {"family": "Chambrier", "given": "Cecile", "initials": "C"}, {"family": "Matysiak", "given": "Konrad", "initials": "K"}, {"family": "Aimasso", "given": "Umberto", "initials": "U"}, {"family": "Rasmussen", "given": "Henrik H", "initials": "HH"}, {"family": "Jukes", "given": "Amelia", "initials": "A"}, {"family": "Kunecki", "given": "Marek", "initials": "M"}, {"family": "Seguy", "given": "David", "initials": "D"}, {"family": "Schneider", "given": "St\u00e9phane M", "initials": "SM"}, {"family": "Daniels", "given": "Joanne", "initials": "J"}, {"family": "Poullenot", "given": "Florian", "initials": "F"}, {"family": "Mundi", "given": "Manpreet S", "initials": "MS"}, {"family": "Matras", "given": "Przemys\u0142aw", "initials": "P"}, {"family": "Folwarski", "given": "Marcin", "initials": "M"}, {"family": "Crivelli", "given": "Adriana", "initials": "A"}, {"family": "Wyer", "given": "Nicola", "initials": "N"}, {"family": "Ellegard", "given": "Lars", "initials": "L"}, {"family": "Santarpia", "given": "Lidia", "initials": "L"}, {"family": "Arvanitakis", "given": "Marianna", "initials": "M"}, {"family": "Spaggiari", "given": "Corrado", "initials": "C"}, {"family": "Lamprecht", "given": "Georg", "initials": "G"}, {"family": "Guglielmi", "given": "Francesco W", "initials": "FW"}, {"family": "Lezo", "given": "Antonella", "initials": "A"}, {"family": "Layec", "given": "Sabrina", "initials": "S"}, {"family": "Boluda", "given": "Esther Ramos", "initials": "ER"}, {"family": "Guz-Mark", "given": "Anat", "initials": "A"}, {"family": "Gandullia", "given": "Paolo", "initials": "P"}, {"family": "Cuerda", "given": "Cristina", "initials": "C"}, {"family": "Osland", "given": "Emma", "initials": "E"}, {"family": "Spagnuolo", "given": "Maria I", "initials": "MI"}, {"family": "Krznaric", "given": "Zeljko", "initials": "Z"}, {"family": "Masconale", "given": "Luisa", "initials": "L"}, {"family": "Chapman", "given": "Brooke", "initials": "B"}, {"family": "Ma\u00edz-Jim\u00e9nez", "given": "Mar\u00eda", "initials": "M"}, {"family": "Orlandoni", "given": "Paolo", "initials": "P"}, {"family": "Martins da Rocha", "given": "Mariana Hollanda", "initials": "MH"}, {"family": "Virgili-Casas", "given": "M Nuria", "initials": "MN"}, {"family": "Doitchinova-Simeonova", "given": "Maryana", "initials": "M"}, {"family": "Czako", "given": "Laszlo", "initials": "L"}, {"family": "Van Gossum", "given": "Andr\u00e8", "initials": "A"}, {"family": "D'Antiga", "given": "Lorenzo", "initials": "L"}, {"family": "Ee", "given": "Looi C", "initials": "LC"}, {"family": "Warodomwichit", "given": "Daruneewan", "initials": "D"}, {"family": "Taus", "given": "Marina", "initials": "M"}, {"family": "Kola\u010dek", "given": "Sanja", "initials": "S"}, {"family": "Thibault", "given": "Ronan", "initials": "R"}, {"family": "Verlato", "given": "Giovanna", "initials": "G"}, {"family": "Serralde-Z\u00fa\u00f1iga", "given": "Aurora E", "initials": "AE"}, {"family": "Botella-Carretero", "given": "Jos\u00e9 I", "initials": "JI"}, {"family": "Aguayo", "given": "Pilar Serrano", "initials": "PS"}, {"family": "Olveira", "given": "Gabriel", "initials": "G"}, {"family": "Chomtho", "given": "Sirinuch", "initials": "S"}, {"family": "Pisprasert", "given": "Veeradej", "initials": "V"}, {"family": "Moisejevs", "given": "Georgijs", "initials": "G"}, {"family": "Murillo", "given": "Ana Zugasti", "initials": "AZ"}, {"family": "J\u00e1uregui", "given": "Ma Estrella Petrina", "initials": "MEP"}, {"family": "D\u00edez", "given": "Marta Bueno", "initials": "MB"}, {"family": "Jahit", "given": "Mohammad Shukri", "initials": "MS"}, {"family": "Densupsoontorn", "given": "Narumon", "initials": "N"}, {"family": "Tamer", "given": "Ali", "initials": "A"}, {"family": "Brillanti", "given": "Giorgia", "initials": "G"}, {"family": "Joly", "given": "Francisca", "initials": "F"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Clin Nutr ESPEN", "issn": "2405-4577", "issn-l": null, "volume": "55", "issue": null, "pages": "212-220"}, "abstract": "To investigate the incidence and the severity of COVID-19 infection in patients enrolled in the database for home parenteral nutrition (HPN) for chronic intestinal failure (CIF) of the European Society for Clinical Nutrition and Metabolism (ESPEN).\r\n\r\nPeriod of observation: March 1st, 2020 March 1st, 2021.\r\n\r\npatients included in the database since 2015 and still receiving HPN on March 1st, 2020 as well as new patients included in the database during the period of observation. Data related to the previous 12 months and recorded on March 1st 2021: 1) occurrence of COVID-19 infection since the beginning of the pandemic (yes, no, unknown); 2) infection severity (asymptomatic; mild, no-hospitalization; moderate, hospitalization no-ICU; severe, hospitalization in ICU); 3) vaccinated against COVID-19 (yes, no, unknown); 4) patient outcome on March 1st 2021: still on HPN, weaned off HPN, deceased, lost to follow up.\r\n\r\nSixty-eight centres from 23 countries included 4680 patients. Data on COVID-19 were available for 55.1% of patients. The cumulative incidence of infection was 9.6% in the total group and ranged from 0% to 21.9% in the cohorts of individual countries. Infection severity was reported as: asymptomatic 26.7%, mild 32.0%, moderate 36.0%, severe 5.3%. Vaccination status was unknown in 62.0% of patients, non-vaccinated 25.2%, vaccinated 12.8%. Patient outcome was reported as: still on HPN 78.6%, weaned off HPN 10.6%, deceased 9.7%, lost to follow up 1.1%. A higher incidence of infection (p = 0.04), greater severity of infection (p < 0.001) and a lower vaccination percentage (p = 0.01) were observed in deceased patients. In COVID-19 infected patients, deaths due to infection accounted for 42.8% of total deaths.\r\n\r\nIn patients on HPN for CIF, the incidence of COVID-19 infection differed greatly among countries. Although the majority of cases were reported to be asymptomatic or have mild symptoms only, COVID-19 was reported to be fatal in a significant proportion of infected patients. Lack of vaccination was associated with a higher risk of death.", "doi": "10.1016/j.clnesp.2023.03.008", "pmid": "37202049", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10060187"}, {"db": "pii", "key": "S2405-4577(23)00075-X"}], "notes": [], "created": "2023-10-04T05:11:29.125Z", "modified": "2023-10-04T07:13:30.687Z"}, {"entity": "publication", "iuid": "19c8f56c67384179ae91bca3ce302683", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19c8f56c67384179ae91bca3ce302683.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19c8f56c67384179ae91bca3ce302683"}}, "title": "COVID-19 and unintended steps towards further equity in global health research.", "authors": [{"family": "Willows", "given": "Tamara Mulenga", "initials": "TM", "orcid": "0000-0003-0760-5574", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a81a219f7e1647789a38f3bdfd754b16.json"}}, {"family": "Oliwa", "given": "Jacquie", "initials": "J"}, {"family": "Onyango", "given": "Onesmus", "initials": "O"}, {"family": "Mkumbo", "given": "Elibariki", "initials": "E"}, {"family": "Maiba", "given": "John", "initials": "J"}, {"family": "Schell", "given": "Carl Otto", "initials": "CO", "orcid": "0000-0002-7904-1336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a40b337b45b471d97a102c355c9d874.json"}}, {"family": "Baker", "given": "Tim", "initials": "T", "orcid": "0000-0001-8727-7018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1454fc20049b4d47865268adf16d104a.json"}}, {"family": "McKnight", "given": "Jacob", "initials": "J", "orcid": "0000-0003-1340-2618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ab57e6a797048338416851ae43170a9.json"}}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "issn-l": "2059-7908", "volume": "8", "issue": "6", "pages": null}, "abstract": "There was, and possibly still is, potential for COVID-19 to disrupt power inequities and contribute to positive transformation in global health research that increases equity. While there is consensus about the need to decolonise by transforming global health, and a roadmap outlining how we could approach it, there are few examples of steps that could be taken to transform the mechanics of global health research. This paper contributes lessons learnt from experiences and reflections of our diverse multinational team of researchers involved in a multicountry research project. We demonstrate the positive impact on our research project of making further steps towards improving equity within our research practices. Some of the approaches adopted include redistributing power to researchers from the countries of interest at various stages in their career, by involving the whole team in decisions about the research; meaningfully involving the whole team in research data analysis; and providing opportunities for all researchers from the countries of interest to voice their perspectives as first authors in publications. Although this approach is consistent with how research guidance suggests research should be run, in reality it does not often happen in this way. The authors of this paper hope that by sharing our experience, we can contribute towards discussions about the processes required to continue developing a global health sector that is equitable and inclusive.", "doi": "10.1136/bmjgh-2023-011888", "pmid": "37328283", "labels": {"Type: Other": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10276961"}, {"db": "pii", "key": "bmjgh-2023-011888"}], "notes": [], "created": "2023-10-04T09:33:08.709Z", "modified": "2023-10-04T11:17:35.824Z"}, {"entity": "publication", "iuid": "3dafb03d45fe4acdb6cd32d1298d72af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3dafb03d45fe4acdb6cd32d1298d72af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3dafb03d45fe4acdb6cd32d1298d72af"}}, "title": "A comprehensive health effects assessment of the use of sanitizers and disinfectants during COVID-19 pandemic: a global survey.", "authors": [{"family": "Hashemi", "given": "Fallah", "initials": "F"}, {"family": "Hoepner", "given": "Lori", "initials": "L"}, {"family": "Hamidinejad", "given": "Farahnaz Soleimani", "initials": "FS"}, {"family": "Haluza", "given": "Daniela", "initials": "D"}, {"family": "Afrashteh", "given": "Sima", "initials": "S"}, {"family": "Abbasi", "given": "Alireza", "initials": "A"}, {"family": "Omeragi\u0107", "given": "Elma", "initials": "E"}, {"family": "Imamovi\u0107", "given": "Belma", "initials": "B"}, {"family": "Rasheed", "given": "Narin A", "initials": "NA"}, {"family": "Taher", "given": "Taqi M J", "initials": "TMJ"}, {"family": "Kurniasari", "given": "Fitri", "initials": "F"}, {"family": "Wazqar", "given": "Dhuha Youssef", "initials": "DY"}, {"family": "Apal\u0131", "given": "\u00d6zge Ceren", "initials": "\u00d6C"}, {"family": "Yildirim", "given": "Ayca Demir", "initials": "AD"}, {"family": "Zhao", "given": "Bo", "initials": "B"}, {"family": "Kalikyan", "given": "Zaruhi", "initials": "Z"}, {"family": "Guo", "given": "Cui", "initials": "C"}, {"family": "Valbuena", "given": "Andrea Chong", "initials": "AC"}, {"family": "Mititelu", "given": "Magdalena", "initials": "M"}, {"family": "Pando", "given": "Carolina Mart\u00ednez", "initials": "CM"}, {"family": "Saridi", "given": "Maria", "initials": "M"}, {"family": "Toska", "given": "Aikaterini", "initials": "A"}, {"family": "Cuba", "given": "Magalys Lopez", "initials": "ML"}, {"family": "Kwadzokpui", "given": "Precious Kwablah", "initials": "PK"}, {"family": "Tadele", "given": "Niguse", "initials": "N"}, {"family": "Nasibova", "given": "Tohfa", "initials": "T"}, {"family": "Harsch", "given": "Stefanie", "initials": "S"}, {"family": "Munkh-Erdene", "given": "Luvsan", "initials": "L"}, {"family": "Menawi", "given": "Wafaa", "initials": "W"}, {"family": "Evangelou", "given": "Efi", "initials": "E"}, {"family": "Dimova", "given": "Antoniya", "initials": "A"}, {"family": "Marinov", "given": "Dimitar", "initials": "D"}, {"family": "Dimitrova", "given": "Teodora", "initials": "T"}, {"family": "Shalimova", "given": "Anna", "initials": "A"}, {"family": "Fouly", "given": "Howieda", "initials": "H"}, {"family": "Suraya", "given": "Anna", "initials": "A"}, {"family": "da Silva Faquim", "given": "Juliana Pereira", "initials": "JP"}, {"family": "Oumayma", "given": "Bouadil", "initials": "B"}, {"family": "Annunziato", "given": "Maria Antonieta", "initials": "MA"}, {"family": "Lalo", "given": "Rezarta", "initials": "R"}, {"family": "Papastavrou", "given": "Evridiki", "initials": "E"}, {"family": "Ade", "given": "Anju D", "initials": "AD"}, {"family": "Caminada", "given": "Susanna", "initials": "S"}, {"family": "Stojkov", "given": "Svetlana", "initials": "S"}, {"family": "Narvaez", "given": "Carmen Gloria", "initials": "CG"}, {"family": "Mudau", "given": "Lutendo Sylvia", "initials": "LS"}, {"family": "Rassas", "given": "Ines", "initials": "I"}, {"family": "Michel", "given": "Daphnee", "initials": "D"}, {"family": "Kaynar", "given": "Nur Sema", "initials": "NS"}, {"family": "Iqbal", "given": "Sehar", "initials": "S"}, {"family": "Elshwekh", "given": "Halla", "initials": "H"}, {"family": "Hossain", "given": "Irin", "initials": "I"}, {"family": "Al-Fayyadh", "given": "Sadeq", "initials": "S"}, {"family": "Sydorchuk", "given": "Aniuta", "initials": "A"}, {"family": "Alnusairat", "given": "Dua'a M H", "initials": "DMH"}, {"family": "Abdullahi", "given": "Asli Mohamed", "initials": "AM"}, {"family": "Iqbal", "given": "Neelam", "initials": "N"}, {"family": "Pandey", "given": "Apsara", "initials": "A"}, {"family": "G\u00f3mez-G\u00f3mez", "given": "Brenda", "initials": "B"}, {"family": "Akyildiz", "given": "Aysenur Gunaydin", "initials": "AG"}, {"family": "Morosan", "given": "Elena", "initials": "E"}, {"family": "Dwarica", "given": "Daniella", "initials": "D"}, {"family": "Dorj", "given": "Gantuya", "initials": "G"}, {"family": "Hasan", "given": "Sumaya Yusuf", "initials": "SY"}, {"family": "Al-Shdayfat", "given": "Noha M", "initials": "NM"}, {"family": "Knezevic", "given": "Bojana", "initials": "B"}, {"family": "Valladares", "given": "Wendy", "initials": "W"}, {"family": "Severi", "given": "Cecilia", "initials": "C"}, {"family": "Fuentes", "given": "Sofia Cuba", "initials": "SC"}, {"family": "Augusto", "given": "Sofia", "initials": "S"}, {"family": "Sidorova", "given": "Elizaveta", "initials": "E"}, {"family": "Moelyaningrum", "given": "Anita Dewi", "initials": "AD"}, {"family": "Alawad", "given": "Tafaul", "initials": "T"}, {"family": "Khalid", "given": "Atiqa", "initials": "A"}, {"family": "Elehamer", "given": "Nafisa M K", "initials": "NMK"}, {"family": "Mihaylova", "given": "Anna", "initials": "A"}, {"family": "Tsigengagel", "given": "Oxana", "initials": "O"}, {"family": "Menouni", "given": "Aziza", "initials": "A"}, {"family": "Wojtecka", "given": "Agnieszka", "initials": "A"}, {"family": "Hod", "given": "Rozita", "initials": "R"}, {"family": "Idayat", "given": "Yusuf Banke", "initials": "YB"}, {"family": "Othman", "given": "Khadija", "initials": "K"}, {"family": "Harfouch", "given": "Rim M", "initials": "RM"}, {"family": "Paunov", "given": "Tsonco", "initials": "T"}, {"family": "Omar", "given": "Meruyert", "initials": "M"}, {"family": "Benderli", "given": "Nana Christine", "initials": "NC"}, {"family": "Nurika", "given": "Globila", "initials": "G"}, {"family": "Amjad", "given": "Sana", "initials": "S"}, {"family": "Elnoamany", "given": "Salma", "initials": "S"}, {"family": "Elesrigy", "given": "Fatma", "initials": "F"}, {"family": "Shaban", "given": "Marwa Mamdouh", "initials": "MM"}, {"family": "Acevedo-L\u00f3pez", "given": "Dom\u00e9nica", "initials": "D"}, {"family": "Kartashova", "given": "Maria", "initials": "M"}, {"family": "Khalaf", "given": "Atika", "initials": "A"}, {"family": "Jaafar", "given": "Sabah Abdullah", "initials": "SA"}, {"family": "Kadhim", "given": "Taisir A", "initials": "TA"}, {"family": "Hweissa", "given": "Nada Ab", "initials": "NA"}, {"family": "Teng", "given": "Yulong", "initials": "Y"}, {"family": "Mohammed", "given": "Fatima E", "initials": "FE"}, {"family": "Sasikumar", "given": "Thayahlini", "initials": "T"}, {"family": "Hikaambo", "given": "Christabel Nangandu", "initials": "CN"}, {"family": "Kharat", "given": "Aditi", "initials": "A"}, {"family": "Lyamtseva", "given": "Ulyana", "initials": "U"}, {"family": "Aldeeb", "given": "Maya Arfan", "initials": "MA"}, {"family": "Pawlas", "given": "Natalia", "initials": "N"}, {"family": "Khorolsuren", "given": "Lkhagvasuren", "initials": "L"}, {"family": "Koonjul", "given": "Roopeshwaree Pallavi", "initials": "RP"}, {"family": "Ma\u00efnassara", "given": "Halima Boubacar", "initials": "HB"}, {"family": "Chahal", "given": "Priyanka", "initials": "P"}, {"family": "Wangeci", "given": "Rose W", "initials": "RW"}, {"family": "Kumar", "given": "Ainur B", "initials": "AB"}, {"family": "Zamora-Corrales", "given": "Irina", "initials": "I"}, {"family": "Gracy", "given": "Stella", "initials": "S"}, {"family": "Mahamat", "given": "Maimouna", "initials": "M"}, {"family": "Adamczyk", "given": "Jakub", "initials": "J"}, {"family": "Rahman", "given": "Haliza Abdul", "initials": "HA"}, {"family": "Matiashova", "given": "Lolita", "initials": "L"}, {"family": "Elsherif", "given": "Omneya Ezzat", "initials": "OE"}, {"family": "Alkhateeb", "given": "Nazdar E", "initials": "NE"}, {"family": "Aleaga", "given": "Yamil\u00e9", "initials": "Y"}, {"family": "Bahrami", "given": "Shima", "initials": "S"}, {"family": "Al-Salihy", "given": "Shaimaa Rahem", "initials": "SR"}, {"family": "Cabrera-Galeana", "given": "Paula", "initials": "P"}, {"family": "Lalic-Popovic", "given": "Mladena", "initials": "M"}, {"family": "Brown-Myrie", "given": "Eugenie", "initials": "E"}, {"family": "Bhandari", "given": "Divya", "initials": "D"}, {"family": "Mayaboti", "given": "Cinderella Akbar", "initials": "CA"}, {"family": "Stani\u0161i\u0107", "given": "Svetlana", "initials": "S"}, {"family": "Pestic", "given": "Sanda Kreitmayer", "initials": "SK"}, {"family": "Bektay", "given": "Muhammed Yunus", "initials": "MY"}, {"family": "Al Sabbah", "given": "Haleama", "initials": "H"}, {"family": "Hashemi", "given": "Saber", "initials": "S"}, {"family": "Assia", "given": "Bouchetara", "initials": "B"}, {"family": "Merritt", "given": "Anne-Sophie", "initials": "A"}, {"family": "Ramzi", "given": "Zhian", "initials": "Z"}, {"family": "Baboolal", "given": "Himawatee", "initials": "H"}, {"family": "Isstaif", "given": "Juman", "initials": "J"}, {"family": "Shami", "given": "Rula", "initials": "R"}, {"family": "Saad", "given": "Rahma", "initials": "R"}, {"family": "Nyirongo", "given": "Temwanani", "initials": "T"}, {"family": "Hoseini", "given": "Mohammad", "initials": "M", "orcid": "0000-0001-5180-3047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88d9726fdadb43758c8e8e5d941b1267.json"}}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Environ Sci Pollut Res Int", "issn": "1614-7499", "issn-l": null, "volume": "30", "issue": "28", "pages": "72368-72388"}, "abstract": "COVID-19 has affected all aspects of human life so far. From the outset of the pandemic, preventing the spread of COVID-19 through the observance of health protocols, especially the use of sanitizers and disinfectants was given more attention. Despite the effectiveness of disinfection chemicals in controlling and preventing COVID-19, there are critical concerns about their adverse effects on human health. This study aims to assess the health effects of sanitizers and disinfectants on a global scale. A total of 91,056 participants from 154 countries participated in this cross-sectional study. Information on the use of sanitizers and disinfectants and health was collected using an electronic questionnaire, which was translated into 26 languages via web-based platforms. The findings of this study suggest that detergents, alcohol-based substances, and chlorinated compounds emerged as the most prevalent chemical agents compared to other sanitizers and disinfectants examined. Most frequently reported health issues include skin effects and respiratory effects. The Chi-square test showed a significant association between chlorinated compounds (sodium hypochlorite and per-chlorine) with all possible health effects under investigation (p-value <0.001). Examination of risk factors based on multivariate logistic regression analysis showed that alcohols and alcohols-based materials were associated with skin effects (OR, 1.98; 95%CI, 1.87-2.09), per-chlorine was associated with eye effects (OR, 1.83; 95%CI, 1.74-1.93), and highly likely with itching and throat irritation (OR, 2.00; 95%CI, 1.90-2.11). Furthermore, formaldehyde was associated with a higher prevalence of neurological effects (OR, 2.17; 95%CI, 1.92-2.44). Furthermore, formaldehyde was associated with a higher prevalence of neurological effects (OR, 2.17; 95%CI, 1.92-2.44). The use of sodium hypochlorite and per-chlorine also had a high chance of having respiratory effects. The findings of the current study suggest that health authorities need to implement more awareness programs about the side effects of using sanitizers and disinfectants during viral epidemics especially when they are used or overused.", "doi": "10.1007/s11356-023-27197-6", "pmid": "37166731", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10173232"}, {"db": "pii", "key": "10.1007/s11356-023-27197-6"}], "notes": [], "created": "2023-10-04T05:12:04.405Z", "modified": "2023-10-04T07:27:53.594Z"}, {"entity": "publication", "iuid": "8d005afcbfa84b5d896a0c02be7a01e0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d005afcbfa84b5d896a0c02be7a01e0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d005afcbfa84b5d896a0c02be7a01e0"}}, "title": "Changes in lifestyle, adiposity, and cardiometabolic markers among young adults in Sweden during the COVID-19 pandemic.", "authors": [{"family": "Ekstr\u00f6m", "given": "Sandra", "initials": "S"}, {"family": "Andersson", "given": "Niklas", "initials": "N"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "Georgelis", "given": "Antonios", "initials": "A"}, {"family": "Ljungman", "given": "Petter L S", "initials": "PLS"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Bergstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2023-05-31", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "23", "issue": "1", "pages": "1026"}, "abstract": "The COVID-19 pandemic has impacted on public health in several ways. The aim of the study was to investigate changes in lifestyle, adiposity, and cardiometabolic markers among young adults in Sweden during the COVID-19 pandemic and their determinants.\r\n\r\nThe study included 1 004 participants from the population-based birth cohort BAMSE. Anthropometrics, body composition (bioelectric impedance analyses), pulse, and blood pressure were measured before (December 2016-May 2019; mean age 22.6 years) and during (October 2020-June 2021; mean age 25.7 years) the COVID-19 pandemic. Lifestyle changes during the pandemic were assessed through a questionnaire.\r\n\r\nAll measures of adiposity (weight, BMI, body fat percentage, trunk fat percentage) and cardiometabolic markers (blood pressure, pulse) increased during the study period (e.g., body fat percentage by a median of + 0.8% in females, p < 0.001, and + 1.5% in males, p < 0.001). Male sex, non-Scandinavian ethnicity, BMI status (underweight and obesity), and changes in lifestyle factors, e.g., decreased physical activity during the pandemic, were associated with higher increase in BMI and/or adiposity.\r\n\r\nLifestyle factors, adiposity and cardiometabolic markers may have been adversely affected among young adults in Sweden during the COVID-19 pandemic compared with the preceding years. Targeted public health measures to reduce obesity and improve healthy lifestyle are important to prevent future non-communicable diseases.", "doi": "10.1186/s12889-023-15998-w", "pmid": "37259040", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Funder: VR": null, "Funder: Forte": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10230124"}, {"db": "pii", "key": "10.1186/s12889-023-15998-w"}], "notes": [], "created": "2023-10-04T09:30:58.793Z", "modified": "2023-10-04T10:39:32.251Z"}, {"entity": "publication", "iuid": "d68c8a168fc6476b970f546ee7eed474", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d68c8a168fc6476b970f546ee7eed474.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d68c8a168fc6476b970f546ee7eed474"}}, "title": "Reduced Binding between Omicron B.1.1.529 and the Human ACE2 Receptor in a Surrogate Virus Neutralization Test for SARS-CoV-2.", "authors": [{"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Kolstad", "given": "Linda", "initials": "L"}, {"family": "Akaberi", "given": "Dario", "initials": "D"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD", "orcid": "0000-0002-7075-1059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4c50079915c44d39c996741c6156bfa.json"}}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B", "orcid": "0000-0003-0229-093X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ffe383004ef44bc6b7639ce49e8f4295.json"}}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5", "orcid": "0000-0001-8608-6551", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d8e20ea891e4e038dddde238aa79627.json"}}], "type": "journal article", "published": "2023-05-30", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "15", "issue": "6", "pages": null}, "abstract": "The current gold standard assay for detecting neutralizing antibodies (NAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the conventional virus neutralization test (cVNT), which requires infectious virus and a biosafety level 3 laboratory. Here, we report the development of a SARS-CoV-2 surrogate virus neutralization test (sVNT) that, with Luminex technology, detects NAbs. The assay was designed to mimic the virus-host interaction and is based on antibody blockage between the human angiotensin-converting enzyme 2 (hACE2) receptor and the spike (S) protein of the Wuhan, Delta, and Omicron (B.1.1.529) variants of SARS-CoV-2. The sVNT proved to have a 100% correlation with a SARS-CoV-2 cVNT regarding qualitative results. Binding between the hACE2 receptor and the S1 domain of the B.1.1.529 lineage of the Omicron variant was not observed in the assay but between the receptor and an S1 + S2 trimer and the receptor binding domain (RBD) in a reduced manner, suggesting less efficient receptor binding for the B.1.1.529 Omicron variant. The results indicate that the SARS-CoV-2 sVNT is a suitable tool for both the research community and the public health service, as it may serve as an efficient diagnostic alternative to the cVNT.", "doi": "10.3390/v15061280", "pmid": "37376580", "labels": {"Category: Proteins": null, "Funder: VR": null, "Category: Serology": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC10301322"}, {"db": "pii", "key": "v15061280"}], "notes": [], "created": "2023-10-04T09:31:46.194Z", "modified": "2023-10-04T10:54:03.277Z"}, {"entity": "publication", "iuid": "de3655e5b5104cc0a72eb07b0ea09364", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/de3655e5b5104cc0a72eb07b0ea09364.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/de3655e5b5104cc0a72eb07b0ea09364"}}, "title": "Intensive care nurses' experiences of caring for patients during the COVID-19 pandemic based on an analysis of blog posts.", "authors": [{"family": "Skoglund", "given": "Karin", "initials": "K", "orcid": "0000-0001-8008-8169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e6fc2925ce9443e865e3dc39411af54.json"}}, {"family": "\u00c5hlman", "given": "Ebba", "initials": "E"}, {"family": "Mallin", "given": "Sofia", "initials": "S"}, {"family": "Holmgren", "given": "Jessica", "initials": "J", "orcid": "0000-0002-8551-3264", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a97a6a6656dc41f8ac7aad2547261322.json"}}], "type": "journal article", "published": "2023-05-30", "journal": {"title": "Nurs Crit Care", "issn": "1478-5153", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "In 2019, coronavirus disease 2019 (COVID-19) broke out worldwide, leading to a pandemic. Studies have shown that COVID-19 patients in intensive care units (ICUs) require more nursing care than other patients. ICU nurses who care for patients with COVID-19 have shown signs of psychological and physical strain.\r\n\r\nThe aim of this study was to illuminate ICU nurses' experiences of caring for patients with COVID-19 in ICUs during the first wave of the pandemic.\r\n\r\nA qualitative, descriptive and inductive approach was used.\r\n\r\nA total of 70 blog posts from 13 bloggers in the United States, Great Britain, Finland and Sweden were analysed using qualitative inductive manifest content analysis.\r\n\r\nThe results reveal an overall theme: 'An overturned existence under extreme conditions'. Furthermore, three categories-'the virus caused changes in work and private lives', 'unreasonable demands', and to hold on to caring ideals thanks to the support of others'-and seven subcategories were identified.\r\n\r\nCaring for patients with COVID-19 during the first wave of the pandemic was demanding because of a lack of knowledge about the disease and the severity of the illness. This led to ICU nurses experiencing extreme conditions that affected various aspects of their lives. Support from colleagues and teamwork were revealed to be particularly important for how nurses dealt with the demands of working during a pandemic, as was sufficient recovery time between work shifts.\r\n\r\nWork in ICUs was challenging and demanding, even before the pandemic. This study contributes to an understanding of the complex work environment that existed in hospitals during the first wave of the COVID-19 pandemic. The knowledge obtained from this study can be used to revise working conditions and identify health interventions for ICU nurses.", "doi": "10.1111/nicc.12931", "pmid": "37248953", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:09:43.513Z", "modified": "2023-10-04T06:07:09.604Z"}, {"entity": "publication", "iuid": "01ff4dc2353e4b8e8cb12a0ca6ed29a3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01ff4dc2353e4b8e8cb12a0ca6ed29a3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01ff4dc2353e4b8e8cb12a0ca6ed29a3"}}, "title": "The impact of the COVID-19 pandemic on adverse fetal outcomes: A cross-sectional study", "authors": [{"family": "Dageli\u0107", "given": "Andrea", "initials": "A", "orcid": "0000-0001-9374-652X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c003b74a9039488c988a6217611179d5.json"}}, {"family": "Mulic", "given": "Emma", "initials": "E"}, {"family": "Kuzmic Prusac", "given": "Ivana", "initials": "I"}, {"family": "Zekic Tomas", "given": "Sandra", "initials": "S"}], "type": "journal-article", "published": "2023-05-26", "journal": {"title": null, "issn": "0025-7974", "issn-l": null, "volume": "102", "issue": "21", "pages": "e33887"}, "abstract": null, "doi": "10.1097/md.0000000000033887", "pmid": null, "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:10:52.794Z", "modified": "2023-10-04T07:01:12.953Z"}, {"entity": "publication", "iuid": "7b561974f87c49d5ae37c5b8d9642013", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b561974f87c49d5ae37c5b8d9642013.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b561974f87c49d5ae37c5b8d9642013"}}, "title": "Nucleocapsid-specific T cell responses associate with control of SARS-CoV-2 in the upper airways before seroconversion.", "authors": [{"family": "Eser", "given": "Tabea M", "initials": "TM"}, {"family": "Baranov", "given": "Olga", "initials": "O"}, {"family": "Huth", "given": "Manuel", "initials": "M"}, {"family": "Ahmed", "given": "Mohammed I M", "initials": "MIM"}, {"family": "De\u00e1k", "given": "Flora", "initials": "F"}, {"family": "Held", "given": "Kathrin", "initials": "K", "orcid": "0000-0001-7057-6935", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f231ea9496f44e7583759b1bfb4ebdc1.json"}}, {"family": "Lin", "given": "Luming", "initials": "L"}, {"family": "Pekayvaz", "given": "Kami", "initials": "K", "orcid": "0000-0003-4040-650X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4eca6461e96449888f127c3fdb1c32ea.json"}}, {"family": "Leunig", "given": "Alexander", "initials": "A", "orcid": "0000-0002-9179-9203", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a485b7ea41942dc93c9b97f7606a207.json"}}, {"family": "Nicolai", "given": "Leo", "initials": "L", "orcid": "0000-0003-0776-5885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea251a7bafc44037b1e396bc701ee5ec.json"}}, {"family": "Pollakis", "given": "Georgios", "initials": "G", "orcid": "0000-0002-9659-5461", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e3c57acb0fe344d2b70287bf40755970.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}, {"family": "Price", "given": "David A", "initials": "DA", "orcid": "0000-0001-9416-2737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/734b7fd55fca47f8b00d1281331ef39a.json"}}, {"family": "Rubio-Acero", "given": "Raquel", "initials": "R"}, {"family": "Reich", "given": "Jakob", "initials": "J"}, {"family": "Falk", "given": "Philine", "initials": "P"}, {"family": "Markgraf", "given": "Alissa", "initials": "A"}, {"family": "Puchinger", "given": "Kerstin", "initials": "K"}, {"family": "Castelletti", "given": "Noemi", "initials": "N"}, {"family": "Olbrich", "given": "Laura", "initials": "L"}, {"family": "Vanshylla", "given": "Kanika", "initials": "K"}, {"family": "Klein", "given": "Florian", "initials": "F", "orcid": "0000-0003-1376-1792", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc5736c1f6d84545aedc698ba8923b72.json"}}, {"family": "Wieser", "given": "Andreas", "initials": "A"}, {"family": "Hasenauer", "given": "Jan", "initials": "J", "orcid": "0000-0002-4935-3312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e7be5dc819640ff93da1f6e76ef6998.json"}}, {"family": "Kroidl", "given": "Inge", "initials": "I"}, {"family": "Hoelscher", "given": "Michael", "initials": "M"}, {"family": "Geldmacher", "given": "Christof", "initials": "C"}], "type": "journal article", "published": "2023-05-24", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "14", "issue": "1", "pages": "2952"}, "abstract": "Despite intensive research since the emergence of SARS-CoV-2, it has remained unclear precisely which components of the early immune response protect against the development of severe COVID-19. Here, we perform a comprehensive immunogenetic and virologic analysis of nasopharyngeal and peripheral blood samples obtained during the acute phase of infection with SARS-CoV-2. We find that soluble and transcriptional markers of systemic inflammation peak during the first week after symptom onset and correlate directly with upper airways viral loads (UA-VLs), whereas the contemporaneous frequencies of circulating viral nucleocapsid (NC)-specific CD4+ and CD8+ T cells correlate inversely with various inflammatory markers and UA-VLs. In addition, we show that high frequencies of activated CD4+ and CD8+ T cells are present in acutely infected nasopharyngeal tissue, many of which express genes encoding various effector molecules, such as cytotoxic proteins and IFN-\u03b3. The presence of IFNG mRNA-expressing CD4+ and CD8+ T cells in the infected epithelium is further linked with common patterns of gene expression among virus-susceptible target cells and better local control of SARS-CoV-2. Collectively, these results identify an immune correlate of protection against SARS-CoV-2, which could inform the development of more effective vaccines to combat the acute and chronic illnesses attributable to COVID-19.", "doi": "10.1038/s41467-023-38020-8", "pmid": "37225706", "labels": {"Category: Proteins": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10209201"}, {"db": "pii", "key": "10.1038/s41467-023-38020-8"}], "notes": [], "created": "2023-10-04T05:08:42.239Z", "modified": "2023-10-04T05:19:11.862Z"}, {"entity": "publication", "iuid": "74d814ab0f594337b2c3250af3cb3500", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/74d814ab0f594337b2c3250af3cb3500.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/74d814ab0f594337b2c3250af3cb3500"}}, "title": "Association between SARS-CoV-2 infection and newly diagnosed hypertension during pregnancy: prospective, population based cohort study.", "authors": [{"family": "\u00d6rtqvist", "given": "Anne K", "initials": "AK", "orcid": "0000-0001-9019-9233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7bfdbeb2a2d848ec928a6c7f7d112465.json"}}, {"family": "Magnus", "given": "Maria C", "initials": "MC"}, {"family": "Dahlqvist", "given": "Elisabeth", "initials": "E"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Johansson", "given": "Kari", "initials": "K", "orcid": "0000-0002-1497-3079", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f592ab7cb9645098896efc10bee41c4.json"}}, {"family": "Sandstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}, {"family": "Stephansson", "given": "Olof", "initials": "O", "orcid": "0000-0003-1528-4563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39af50356a574c80ba6bd2227ecb5cf5.json"}}], "type": "journal article", "published": "2023-05-24", "journal": {"title": "BMJ Med", "issn": "2754-0413", "issn-l": null, "volume": "2", "issue": "1", "pages": "e000465"}, "abstract": "To study the association between SARS-CoV-2 infection and newly diagnosed hypertension during pregnancy.\r\n\r\nProspective, population based cohort study.\r\n\r\nAll singleton pregnancies after 22 completed gestational weeks registered in the Swedish Pregnancy Register and the Medical Birth Registry of Norway, from 1 March 2020 to 24 May 2022.\r\n\r\n312 456 individuals available for analysis (201 770 in Sweden and 110 686 in Norway), with pregnancies that reached 42 completed gestational weeks by the end of follow-up in the pregnancy registries, excluding individuals with SARS-CoV-2 infection before pregnancy and those with a diagnosis of pre-existing hypertension or onset of hypertension before 20 gestational weeks.\r\n\r\nNewly diagnosed hypertension during pregnancy was defined as a composite outcome of a diagnosis of gestational hypertension, pre-eclampsia, HELLP (haemolysis, elevated liver enzymes, low platelets) syndrome, or eclampsia, from gestational week 20 to one week after delivery. The association between SARS-CoV-2 infection and hypertension during pregnancy was investigated with a stratified Cox proportional hazard model, adjusting for maternal age, body mass index, parity, smoking, region of birth, education, income, coexisting medical conditions, previous hypertension during pregnancy, number of healthcare visits during the past year, and vaccination against SARS-CoV-2. Pre-eclampsia was also analysed as a separate outcome.\r\n\r\nOf 312 456 individuals available for analysis, 8% (n=24 566) had SARS-CoV-2 infection any time during pregnancy, 6% (n=18 051) had a diagnosis of hypertension during pregnancy, and 3% (9899) had pre-eclampsia. SARS-CoV-2 infection during pregnancy was not associated with an increased risk of hypertension during pregnancy (adjusted hazard ratio 0.99, 95% confidence interval 0.93 to 1.04) or pre-eclampsia (0.98, 0.87 to 1.10). The results were similar for SARS-CoV-2 infection in all gestational trimesters and in different time periods that corresponded to dominance of different variants of the SARS-CoV-2 virus.\r\n\r\nThis population based study did not find any evidence of an association between SARS-CoV-2 infection during pregnancy and an increased risk of hypertension during pregnancy or pre-eclampsia.", "doi": "10.1136/bmjmed-2022-000465", "pmid": "37275554", "labels": {"Category: Health": null, "Funder: H2020": null, "Funder: NordForsk": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10230329"}, {"db": "pii", "key": "bmjmed-2022-000465"}], "notes": [], "created": "2023-10-04T09:31:57.973Z", "modified": "2023-10-04T10:59:41.792Z"}, {"entity": "publication", "iuid": "a41b6cfc55034bb69940f6ea84543eda", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a41b6cfc55034bb69940f6ea84543eda.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a41b6cfc55034bb69940f6ea84543eda"}}, "title": "Insomnia and job stressors among healthcare workers who served COVID-19 patients in Bangladesh.", "authors": [{"family": "Rahman", "given": "Farzana", "initials": "F"}, {"family": "Dalal", "given": "Koustuv", "initials": "K"}, {"family": "Hasan", "given": "Mehedi", "initials": "M"}, {"family": "Islam", "given": "Tariful", "initials": "T"}, {"family": "Tuli", "given": "Samiha Nahar", "initials": "SN"}, {"family": "Akter", "given": "Asma", "initials": "A"}, {"family": "Tanvir", "given": "K M", "initials": "KM"}, {"family": "Islam", "given": "Khairul", "initials": "K"}, {"family": "Rahman", "given": "Ashikur", "initials": "A"}, {"family": "Nabi", "given": "Mohammad Hayatun", "initials": "MH"}, {"family": "Rahman", "given": "Mohammad Lutfor", "initials": "ML"}, {"family": "Hossain Hawlader", "given": "Mohammad Delwer", "initials": "MD"}], "type": "journal article", "published": "2023-05-23", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "issn-l": null, "volume": "23", "issue": "1", "pages": "523"}, "abstract": "The global outbreak of COVID-19 has created unprecedented havoc among health care workers, resulting in significant psychological strains like insomnia. This study aimed to analyze insomnia prevalence and job stressors among Bangladeshi health care workers in COVID-19 units.\r\n\r\nWe conducted this cross-sectional study to assess insomnia severity from January to March 2021 among 454 health care workers working in multiple hospitals in Dhaka city with active COVID-dedicated units. We selected 25 hospitals conveniently. We used a structured questionnaire for face-to-face interviews containing sociodemographic variables and job stressors. The severity of insomnia was measured by the Insomnia Severity Scale (ISS). The scale has seven items to evaluate the rate of insomnia, which was categorized as the absence of Insomnia (0-7); sub-threshold Insomnia (8-14); moderate clinical Insomnia (15-21); and severe clinical Insomnia (22-28). To identify clinical insomnia, a cut-off value of 15 was decided primarily. A cut-off score of 15 was initially proposed for identifying clinical insomnia. We performed a chi-square test and adjusted logistic regression to explore the association of different independent variables with clinically significant insomnia using the software SPSS version 25.0.\r\n\r\n61.5% of our study participants were females. 44.9% were doctors, 33.9% were nurses, and 21.1% were other health care workers. Insomnia was more dominant among doctors and nurses (16.2% and 13.6%, respectively) than others (4.2%). We found clinically significant insomnia was associated with several job stressors (p < 0.05). In binary logistic regression, having sick leave (OR = 0.248, 95% CI = 0.116, 0.532) and being entitled to risk allowance (OR = 0.367, 95% CI = 0.124.1.081) showed lower odds of developing Insomnia. Previously diagnosed with COVID-19-positive health care workers had an OR of 2.596 (95% CI = 1.248, 5.399), pointing at negative experiences influencing insomnia. In addition, we observed that any training on risk and hazard increased the chances of suffering from Insomnia (OR = 1.923, 95% CI = 0.934, 3.958).\r\n\r\nIt is evident from the findings that the volatile existence and ambiguity of COVID-19 have induced significant adverse psychological effects and subsequently directed our HCWs toward disturbed sleep and insomnia. The study recommends the imperativeness to formulate and implement collaborative interventions to help HCWs cope with this crisis and mitigate the mental stresses they experience during the pandemic.", "doi": "10.1186/s12913-023-09464-x", "pmid": "37221591", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10204693"}, {"db": "pii", "key": "10.1186/s12913-023-09464-x"}], "notes": [], "created": "2023-10-04T05:10:58.106Z", "modified": "2023-10-04T07:02:39.981Z"}, {"entity": "publication", "iuid": "7e426d44c7a94201b356d6ffe6de95e6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e426d44c7a94201b356d6ffe6de95e6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e426d44c7a94201b356d6ffe6de95e6"}}, "title": "Clustering Analysis Identified Three Long COVID Phenotypes and Their Association with General Health Status and Working Ability.", "authors": [{"family": "Kisiel", "given": "Marta A", "initials": "MA"}, {"family": "Lee", "given": "Seika", "initials": "S"}, {"family": "Malmquist", "given": "Sara", "initials": "S", "orcid": "0009-0002-1404-9721", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2beb89d6d65143b1b212af06fd5315ea.json"}}, {"family": "Rykatkin", "given": "Oliver", "initials": "O"}, {"family": "Holgert", "given": "Sebastian", "initials": "S"}, {"family": "Janols", "given": "Helena", "initials": "H"}, {"family": "Janson", "given": "Christer", "initials": "C"}, {"family": "Zhou", "given": "Xingwu", "initials": "X", "orcid": "0000-0002-9831-9102", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9497b3ea54cc45be9ee3e7fe596b184c.json"}}], "type": "journal article", "published": "2023-05-23", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "12", "issue": "11", "pages": null}, "abstract": "This study aimed to distinguish different phenotypes of long COVID through the post-COVID syndrome (PCS) score based on long-term persistent symptoms following COVID-19 and evaluate whether these symptoms affect general health and work ability. In addition, the study identified predictors for severe long COVID.\r\n\r\nThis cluster analysis included cross-sectional data from three cohorts of patients after COVID-19: non-hospitalized (n = 401), hospitalized (n = 98) and those enrolled at the post-COVID outpatient's clinic (n = 85). All the subjects responded to the survey on persistent long-term symptoms and sociodemographic and clinical factors. K-Means cluster analysis and ordinal logistic regression were used to create PCS scores that were used to distinguish patients' phenotypes.\r\n\r\n506 patients with complete data on persistent symptoms were divided into three distinct phenotypes: none/mild (59%), moderate (22%) and severe (19%). The patients with severe phenotype, with the predominating symptoms were fatigue, cognitive impairment and depression, had the most reduced general health status and work ability. Smoking, snuff, body mass index (BMI), diabetes, chronic pain and symptom severity at COVID-19 onset were factors predicting severe phenotype.\r\n\r\nThis study suggested three phenotypes of long COVID, where the most severe was associated with the highest impact on general health status and working ability. This knowledge on long COVID phenotypes could be used by clinicians to support their medical decisions regarding prioritizing and more detailed follow-up of some patient groups.", "doi": "10.3390/jcm12113617", "pmid": "37297812", "labels": {"Category: Social Science & Humanities": null, "Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10253616"}, {"db": "pii", "key": "jcm12113617"}], "notes": [], "created": "2023-10-04T09:31:36.523Z", "modified": "2023-10-04T10:50:11.813Z"}, {"entity": "publication", "iuid": "8c1fa59dc74846e69add24cb8640bd11", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c1fa59dc74846e69add24cb8640bd11.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c1fa59dc74846e69add24cb8640bd11"}}, "title": "The risk for celiac disease after Covid-19 infection.", "authors": [{"family": "Lexner", "given": "Jesper", "initials": "J"}, {"family": "Lindroth", "given": "Ylva", "initials": "Y"}, {"family": "Sj\u00f6berg", "given": "Klas", "initials": "K"}], "type": "journal article", "published": "2023-05-22", "journal": {"title": "BMC Gastroenterol", "issn": "1471-230X", "issn-l": null, "volume": "23", "issue": "1", "pages": "174"}, "abstract": "Celiac disease (CD) is an autoimmune disease leading to gastrointestinal symptoms and mineral deficiencies. The pathogenetic mechanisms, besides the clear HLA association, are elusive. Among environmental factors infections have been proposed. Covid-19 infection results in a systemic inflammatory response that often also involves the gastrointestinal tract. The aim of the present study was to investigate whether Covid-19 infection could increase the risk for CD.\r\n\r\nAll patients, both children and adults, in the county Sk\u00e5ne (1.4 million citizens) in southern Sweden with newly diagnosed biopsy- or serology-verified CD or a positive tissue transglutaminase antibody test (tTG-ab) during 2016-2021 were identified from registries at the Departments of Pathology and Immunology, respectively. Patients with a positive Covid-19 PCR or antigen test in 2020 and 2021 were identified from the Public Health Agency of Sweden.\r\n\r\nDuring the Covid-19 pandemic (March 2020 - December 2021), there were 201 050 cases of Covid-19 and 568 patients with biopsy- or serology-verified CD or a first-time positive tTG-ab tests, of which 35 patients had been infected with Covid-19 before CD. The incidence of verified CD and tTG-ab positivity was lower in comparison to before the pandemic (May 2018 - February 2020; 22.5 vs. 25.5 cases per 100 000 person-years, respectively, incidence rate difference (IRD) -3.0, 95% CI -5.7 - -0.3, p = 0.028). The incidence of verified CD and tTG-ab positivity in patients with and without prior Covid-19 infection was 21.1 and 22.4 cases per 100 000 person-years, respectively (IRD - 1.3, 95% CI -8.5-5.9, p = 0.75).\r\n\r\nOur results indicate that Covid-19 is not a risk factor for CD development. While gastrointestinal infections seem to be an important part of the CD pathogenesis, respiratory infections probably are of less relevance.", "doi": "10.1186/s12876-023-02795-3", "pmid": "37217874", "labels": {"Category: Serology": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10202072"}, {"db": "pii", "key": "10.1186/s12876-023-02795-3"}], "notes": [], "created": "2023-10-04T05:09:38.514Z", "modified": "2023-10-04T06:04:13.447Z"}, {"entity": "publication", "iuid": "f755a5acb7b34b63ad7d93b44e2f29eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f755a5acb7b34b63ad7d93b44e2f29eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f755a5acb7b34b63ad7d93b44e2f29eb"}}, "title": "Serum IL-23, IL-10, and TNF-\u03b1 predict in-hospital mortality in COVID-19 patients.", "authors": [{"family": "Smail", "given": "Shukur Wasman", "initials": "SW"}, {"family": "Babaei", "given": "Esmaeil", "initials": "E"}, {"family": "Amin", "given": "Kawa", "initials": "K"}, {"family": "Abdulahad", "given": "Wayel H", "initials": "WH"}], "type": "journal article", "published": "2023-05-22", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "1145840"}, "abstract": "The hyperinflammatory response, caused by severe acute respiratory syndrome-2 (SARS-CoV-2), is the most common cause of death in patients with coronavirus disease 2019 (COVID-19). The etiopathogenesis of this illness is not fully understood. Macrophages appear to play a key part in COVID-19's pathogenic effects. Therefore, this study aims to examine serum inflammatory cytokines associated with the activation state of macrophages in COVID-19 patients and attempt to find accurate predictive markers for disease severity and mortality risk in hospital.\r\n\r\n180 patients with COVID-19 and 90 healthy controls (HCs) participated in this study. Patients were divided into three different subgroups, mild (n=81), severe (n=60), and critical groups (n=39). Serum samples were collected and IL (Interleukin)-10, IL-23, tumor necrosis factor-alpha (TNF-\u03b1), interferon-gamma (IFN-\u03b3), IL-17, monocyte chemoattractant protein-1 (MCP-1) and chemokine ligand 3 (CCL3) were determined by ELISA. In parallel, myeloperoxidase (MPO) and C-reactive protein (CRP) were measured using colorimetric and electrochemiluminescence methods, respectively. Data were collected, and their associations with disease progression and mortality were assessed using regression models and receiver operating characteristic (ROC) curves.\r\n\r\nCompared to HCs, a significant increase in IL-23, IL-10, TNF-\u03b1, IFN-\u03b3 and MCP-1, were observed in COVID-19 patients. Serum levels of IL-23, IL-10, and TNF-\u03b1 were significantly higher in COVID-19 patients with critical cases compared to mild and severe cases, and correlated positively with CRP level. However, non-significant changes were found in serum MPO and CCL3 among the studied groups. Moreover, significant positive association has been observed among increased IL-10, IL-23 and TNF-\u03b1 in serum of COVID-19 patients. Furthermore, a binary logistic regression model was applied to predict death's independent factors. Results showed that IL-10 alone or in combination with IL23 and TNF-\u03b1 are strongly linked with non-survivors in COVID-19 patients. Finally, ROC curve results uncovered that IL-10, IL-23 and TNF-\u03b1 were excellent predictors for prognosing COVID-19.\r\n\r\nThe elevations of IL-10, IL-23, and TNF-\u03b1 levels were seen in severe and critical cases of COVID-19 patients and their elevations were linked to the in-hospital mortality of the disease. A prediction model shows that the determination of these cytokines upon admission is important and should be done on COVID-19 patients as a way of evaluating the prognosis of the disease. COVID-19 Patients with high IL-10, IL-23, and TNF-\u03b1 on admission are more likely to experience a severe form of the disease; therefore, those patients should be cautionary monitored and treated.", "doi": "10.3389/fimmu.2023.1145840", "pmid": "37283736", "labels": {"Category: Biochemistry": null, "Category: Serology": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10239952"}], "notes": [], "created": "2023-10-04T09:30:09.738Z", "modified": "2023-10-04T09:50:07.803Z"}, {"entity": "publication", "iuid": "e84173f451f64b809dc0a626971777c8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e84173f451f64b809dc0a626971777c8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e84173f451f64b809dc0a626971777c8"}}, "title": "Staff quality of working life and turnover intentions in municipal nursing care and social welfare: a cross-sectional study.", "authors": [{"family": "Engstr\u00f6m", "given": "Maria", "initials": "M", "orcid": "0000-0002-9912-5350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5497902ecdbb4df0a2678becfdb2678b.json"}}, {"family": "Jarnheden", "given": "Sofia Hanberger", "initials": "SH", "orcid": "0000-0003-4864-2400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/802cfff423144af39472f93e1dd5af5f.json"}}, {"family": "Tham", "given": "Pia", "initials": "P", "orcid": "0000-0003-4155-810X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8544cc6baab44c1c8a8d4fc86653c70f.json"}}], "type": "journal article", "published": "2023-05-19", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "issn-l": null, "volume": "22", "issue": "1", "pages": "171"}, "abstract": "Nurses and social workers are two common professions with a university degree working within municipal nursing care and social welfare. Both groups have high turnover intention rates, and there is a need to better understand their quality of working life and turnover intentions in general and more specifically during the Covid-19 pandemic. This study investigated associations between working life, coping strategies and turnover intentions of staff with a university degree working within municipal care and social welfare during the Covid-19 pandemic.\r\n\r\nA cross-sectional design; 207 staff completed questionnaires and data were analyzed using multiple linear regression analyses.\r\n\r\nTurnover intentions were common. For registered nurses 23% thought of leaving the workplace and 14% the profession 'rather often' and 'very often/always'. The corresponding figures for social workers were 22% (workplace) and 22% (profession). Working life variables explained 34-36% of the variance in turnover intentions. Significant variables in the multiple linear regression models were work-related stress, home-work interface and job-career satisfaction (both for the outcome turnover intentions profession and workplace) and Covid-19 exposure/patients (turnover intentions profession). For the chosen coping strategies, 'exercise', 'recreation and relaxation' and 'improving skills', the results (associations with turnover) were non-significant. However, comparing the groups social workers reported that they used 'recreation and relaxation' more often than were reported by registered nurses.\r\n\r\nMore work-related stress, worse home-work interface and less job-career satisfaction together with Covid-19 exposure/patients (Covid-19 only for turnover profession) increase turnover intentions. Recommendations are that managers should strive for better home-work interface and job-career satisfaction, monitor and counteract work-related stress to prevent turnover intentions.", "doi": "10.1186/s12912-023-01339-0", "pmid": "37202759", "labels": {"Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10195664"}, {"db": "pii", "key": "10.1186/s12912-023-01339-0"}], "notes": [], "created": "2023-10-04T05:09:54.134Z", "modified": "2023-10-04T06:22:41.430Z"}, {"entity": "publication", "iuid": "3f935702fdea4236995c2f3e832343d1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f935702fdea4236995c2f3e832343d1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f935702fdea4236995c2f3e832343d1"}}, "title": "Detoxified synthetic bacterial membrane vesicles as a vaccine platform against bacteria and SARS-CoV-2.", "authors": [{"family": "Park", "given": "Kyong-Su", "initials": "K"}, {"family": "Svennerholm", "given": "Kristina", "initials": "K"}, {"family": "Crescitelli", "given": "Rossella", "initials": "R"}, {"family": "L\u00e4sser", "given": "Cecilia", "initials": "C"}, {"family": "Gribonika", "given": "Inta", "initials": "I"}, {"family": "Andersson", "given": "Mickael", "initials": "M"}, {"family": "Bostr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Alalam", "given": "Hanna", "initials": "H"}, {"family": "Harandi", "given": "Ali M", "initials": "AM"}, {"family": "Farewell", "given": "Anne", "initials": "A"}, {"family": "L\u00f6tvall", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2023-05-19", "journal": {"title": "J Nanobiotechnology", "issn": "1477-3155", "issn-l": null, "volume": "21", "issue": "1", "pages": "156"}, "abstract": "The development of vaccines based on outer membrane vesicles (OMV) that naturally bud off from bacteria is an evolving field in infectious diseases. However, the inherent inflammatory nature of OMV limits their use as human vaccines. This study employed an engineered vesicle technology to develop synthetic bacterial vesicles (SyBV) that activate the immune system without the severe immunotoxicity of OMV. SyBV were generated from bacterial membranes through treatment with detergent and ionic stress. SyBV induced less inflammatory responses in macrophages and in mice compared to natural OMV. Immunization with SyBV or OMV induced comparable antigen-specific adaptive immunity. Specifically, immunization with Pseudomonas aeruginosa-derived SyBV protected mice against bacterial challenge, and this was accompanied by significant reduction in lung cell infiltration and inflammatory cytokines. Further, immunization with Escherichia coli-derived SyBV protected mice against E. coli sepsis, comparable to OMV-immunized group. The protective activity of SyBV was driven by the stimulation of B-cell and T-cell immunity. Also, SyBV were engineered to display the SARS-CoV-2 S1 protein on their surface, and these vesicles induced specific S1 protein antibody and T-cell responses. Collectively, these results demonstrate that SyBV may be a safe and efficient vaccine platform for the prevention of bacterial and viral infections.", "doi": "10.1186/s12951-023-01928-w", "pmid": "37208676", "labels": {"Funder: VR": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10196325"}, {"db": "pii", "key": "10.1186/s12951-023-01928-w"}], "notes": [], "created": "2023-10-04T05:12:11.703Z", "modified": "2023-10-04T08:12:16.374Z"}, {"entity": "publication", "iuid": "cdcd3ca0f01044869cd89862392e5e88", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cdcd3ca0f01044869cd89862392e5e88.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cdcd3ca0f01044869cd89862392e5e88"}}, "title": "Working conditions for healthcare workers at a Swedish university hospital infectious disease department during the COVID-19 pandemic: barriers and facilitators to maintaining employee wellbeing.", "authors": [{"family": "Veje", "given": "Malin", "initials": "M"}, {"family": "Linden", "given": "Karolina", "initials": "K"}, {"family": "Sengpiel", "given": "Verena", "initials": "V"}, {"family": "Carlsson", "given": "Ylva", "initials": "Y"}, {"family": "Jonsdottir", "given": "Ingibj\u00f6rg H", "initials": "IH"}, {"family": "Degl'Innocenti", "given": "Alessio", "initials": "A"}, {"family": "Ahlstrom", "given": "Linda", "initials": "L"}, {"family": "Wijk", "given": "Helle", "initials": "H"}, {"family": "Akerstrom", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2023-05-18", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "14", "issue": null, "pages": "1183084"}, "abstract": "Healthcare workers (HCWs) at infectious disease departments have held the frontline during the COVID-19 pandemic. This study aimed to identify barriers and facilitators to maintaining the employees' wellbeing that may be used to increase preparedness for future pandemics within ID Departments.\r\n\r\nIn September 2020, a web-based survey on demographics and work environment was distributed to all HCWs at the Infectious Disease Department at Sahlgrenska University Hospital. Results were compared with a pre-COVID-19 survey from October 2019. A quantitative analysis of the overall effects of the pandemic on the working conditions of HCWs was conducted; in addition, a qualitative content analysis of open-ended responses was performed.\r\n\r\nIn total, 222 and 149 HCWs completed the pre-COVID-19 and COVID-19 surveys (84 and 54% response rate), respectively. Overall, we found significant changes regarding increased workload, lack of emotional support in stressful work situations, and inability to recover after shifts. These factors correlated both with younger age and concern of becoming infected. The open-ended answers (n = 103, 69%) revealed five generic categories (Workload; Organizational support; Worry and ethical stress; Capability; and Cooperation and unity) with a total of 14 identified factors representing plausible individual and organizational-level barriers or facilitators to sustained employee wellbeing.\r\n\r\nYounger HCWs as well as those expressing worries about contracting the infection were found to be particularly affected during the COVID-19 pandemic and these groups may require additional support in future outbreaks. Factors both increasing and decreasing the pandemic-induced negative health consequences for HCWs were identified; this knowledge may be utilized in the future.", "doi": "10.3389/fpsyg.2023.1183084", "pmid": "37275708", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10233109"}], "notes": [], "created": "2023-10-04T09:31:06.907Z", "modified": "2023-10-04T10:43:01.107Z"}, {"entity": "publication", "iuid": "10db20243623418cb19d0d22385e71b6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/10db20243623418cb19d0d22385e71b6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/10db20243623418cb19d0d22385e71b6"}}, "title": "Vision impairment is common in non-hospitalised patients with post-COVID-19 syndrome.", "authors": [{"family": "Johansson", "given": "Jan", "initials": "J", "orcid": "0000-0002-1093-4179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92589deccb094908acfe20279eab5462.json"}}, {"family": "M\u00f6ller", "given": "Marika", "initials": "M", "orcid": "0000-0001-8700-5186", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cddc264c52e1464ea162c7d9146f9021.json"}}, {"family": "Markovic", "given": "Gabriela", "initials": "G", "orcid": "0000-0002-7500-9531", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e9609af7155478eb2c7cd90694c648e.json"}}, {"family": "Borg", "given": "Kristian", "initials": "K", "orcid": "0000-0001-8748-1772", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c78e26fb1a414c69834b7261e2f93dad.json"}}], "type": "journal article", "published": "2023-05-18", "journal": {"title": "Clin Exp Optom", "issn": "1444-0938", "issn-l": null, "volume": null, "issue": null, "pages": "1-8"}, "abstract": "Vision-related problems can be part of longstanding sequelae after COVID-19 and hamper the return to work and daily activities. Knowledge about symptoms, visual, and oculomotor dysfunctions is however scarce, particularly for non-hospitalised patients. Clinically applicable tools are needed as support in the assessment and determination of intervention needs.\r\n\r\nThe purpose of this study was to evaluate vision-related symptoms, assess visual and oculomotor function, and to test the clinical assessment of saccadic eye movements and sensitivity to visual motion in non-hospitalised post-COVID-19 outpatients. The patients (n = 38) in this observational cohort study were recruited from a post-COVID-19 clinic and had been referred for neurocognitive assessment.\r\n\r\nPatients who reported vision-related symptoms reading problems and intolerance to movement in the environment were examined. A structured symptom assessment and a comprehensive vision examination were undertaken, and saccadic eye movements and visual motion sensitivity were assessed.\r\n\r\nHigh symptom scores (26-60%) and prevalence of visual function impairments were observed. An increased symptom score when reading was associated with less efficient saccadic eye movement behaviour (p < 0.001) and binocular dysfunction (p = 0.029). Patients with severe symptoms in visually busy places scored significantly higher on the Visual Motion Sensitivity Clinical Test Protocol (p = 0.029).\r\n\r\nVision-related symptoms and impairments were prevalent in the study group. The Developmental Eye Movement Test and the Visual Motion Sensitivity Clinical Test Protocol showed promise for clinical assessment of saccadic performance and sensitivity to movement in the environment. Further study will be required to explore the utility of these tools.", "doi": "10.1080/08164622.2023.2213826", "pmid": "37201931", "labels": {"Category: Social Science & Humanities": null, "Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:10:45.543Z", "modified": "2023-10-04T06:57:42.564Z"}, {"entity": "publication", "iuid": "1ef0f962c9724dd284a6914a33072c9a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ef0f962c9724dd284a6914a33072c9a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ef0f962c9724dd284a6914a33072c9a"}}, "title": "Long COVID is primarily a Spike protein Induced Thrombotic Vasculitis", "authors": [{"family": "Kerr", "given": "Robin", "initials": "R", "orcid": "0000-0003-2480-2748", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72bb5381b3d84c7fa0de3fee9efbef73.json"}}, {"family": "Carroll", "given": "Harriet A", "initials": "HA", "orcid": "0000-0002-4998-4675", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/851010212d214d9091381760df4427e4.json"}}], "type": "posted-content", "published": "2023-05-18", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.21203/rs.3.rs-2939263/v1", "pmid": null, "labels": {"Category: Post-COVID": null, "Category: Proteins": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:08:39.096Z", "modified": "2023-10-04T05:17:34.352Z"}, {"entity": "publication", "iuid": "c2a2de1360d04408925c33cdb37d5443", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2a2de1360d04408925c33cdb37d5443.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2a2de1360d04408925c33cdb37d5443"}}, "title": "COVID-19 responses restricted abilities and aspirations for mobility and migration: insights from diverse cities in four continents.", "authors": [{"family": "Jolivet", "given": "Dominique", "initials": "D"}, {"family": "Fransen", "given": "Sonja", "initials": "S", "orcid": "0000-0002-7709-4418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/974425d862624044868ef165bca12048.json"}}, {"family": "Adger", "given": "William Neil", "initials": "WN", "orcid": "0000-0003-4244-2854", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c8a100ec8be42b7bb612dcb9f9ef6ab.json"}}, {"family": "F\u00e1bos", "given": "Anita", "initials": "A", "orcid": "0000-0001-6178-6439", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d17ce3e46d3645dfa4caf5012d4d6499.json"}}, {"family": "Abu", "given": "Mumuni", "initials": "M"}, {"family": "Allen", "given": "Charlotte", "initials": "C"}, {"family": "Boyd", "given": "Emily", "initials": "E", "orcid": "0000-0002-1643-9718", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ad7922a45d94ca2b93584b4835ab1f4.json"}}, {"family": "Carr", "given": "Edward R", "initials": "ER", "orcid": "0000-0001-7784-471X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ac45aa9461b4a42b481371372941be6.json"}}, {"family": "Codjoe", "given": "Samuel Nii Ardey", "initials": "SNA"}, {"family": "Gavonel", "given": "Maria Franco", "initials": "MF", "orcid": "0000-0003-2377-5987", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a3bea59d3fa4acc95f7ec4e9487fa7f.json"}}, {"family": "Gemenne", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Rocky", "given": "Mahmudol Hasan", "initials": "MH"}, {"family": "Lantz", "given": "Jozefina", "initials": "J"}, {"family": "Maculule", "given": "Domingos", "initials": "D"}, {"family": "de Campos", "given": "Ricardo Safra", "initials": "RS"}, {"family": "Siddiqui", "given": "Tasneem", "initials": "T"}, {"family": "Zickgraf", "given": "Caroline", "initials": "C"}], "type": "journal article", "published": "2023-05-18", "journal": {"title": "Humanit Soc Sci Commun", "issn": "2662-9992", "issn-l": null, "volume": "10", "issue": "1", "pages": "250"}, "abstract": "Research on the impacts of COVID-19 on mobility has focused primarily on the increased health vulnerabilities of involuntary migrant and displaced populations. But virtually all migration flows have been truncated and altered because of reduced economic and mobility opportunities of migrants. Here we use a well-established framework of migration decision-making, whereby individual decisions combine the aspiration and ability to migrate, to explain how public responses to the COVID-19 pandemic alter migration patterns among urban populations across the world. The principal responses to COVID-19 pandemic that affected migration are: 1) through travel restrictions and border closures, 2) by affecting abilities to move through economic and other means, and 3) by affecting aspirations to move. Using in-depth qualitative data collected in six cities in four continents (Accra, Amsterdam, Brussels, Dhaka, Maputo, and Worcester), we explore how populations with diverse levels of education and occupations were affected in their current and future mobility decisions. We use data from interviews with sample of internal and international migrants and non-migrants during the 2020 COVID-19 pandemic outbreak to identify the mechanisms through which the pandemic affected their mobility decisions. The results show common processes across the different geographical contexts: individuals perceived increased risks associated with further migration, which affected their migration aspirations, and had reduced abilities to migrate, all of which affected their migration decision-making processes. The results also reveal stark differences in perceived and experienced migration decision-making across precarious migrant groups compared to high-skilled and formally employed international migrants in all settings. This precarity of place is particularly evident in low-income marginalised populations.", "doi": "10.1057/s41599-023-01721-y", "pmid": "37250294", "labels": {"Funder: H2020": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10195652"}, {"db": "pii", "key": "1721"}], "notes": [], "created": "2023-10-04T05:11:03.101Z", "modified": "2023-10-04T07:05:57.264Z"}, {"entity": "publication", "iuid": "c44cf098ca084ba9a279d94f886e5650", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c44cf098ca084ba9a279d94f886e5650.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c44cf098ca084ba9a279d94f886e5650"}}, "title": "Telemedicine for diabetes management during COVID-19: what we have learnt, what and how to implement.", "authors": [{"family": "Rosta", "given": "Laszlo", "initials": "L"}, {"family": "Menyhart", "given": "Adrienn", "initials": "A"}, {"family": "Mahmeed", "given": "Wael Al", "initials": "WA"}, {"family": "Al-Rasadi", "given": "Khalid", "initials": "K"}, {"family": "Al-Alawi", "given": "Kamila", "initials": "K"}, {"family": "Banach", "given": "Maciej", "initials": "M"}, {"family": "Banerjee", "given": "Yajnavalka", "initials": "Y"}, {"family": "Ceriello", "given": "Antonio", "initials": "A"}, {"family": "Cesur", "given": "Mustafa", "initials": "M"}, {"family": "Cosentino", "given": "Francesco", "initials": "F"}, {"family": "Firenze", "given": "Alberto", "initials": "A"}, {"family": "Galia", "given": "Massimo", "initials": "M"}, {"family": "Goh", "given": "Su-Yen", "initials": "S"}, {"family": "Janez", "given": "Andrej", "initials": "A"}, {"family": "Kalra", "given": "Sanjay", "initials": "S"}, {"family": "Kapoor", "given": "Nitin", "initials": "N"}, {"family": "Lessan", "given": "Nader", "initials": "N"}, {"family": "Lotufo", "given": "Paulo", "initials": "P"}, {"family": "Papanas", "given": "Nikolaos", "initials": "N"}, {"family": "Rizvi", "given": "Ali A", "initials": "AA"}, {"family": "Sahebkar", "given": "Amirhossein", "initials": "A"}, {"family": "Santos", "given": "Raul D", "initials": "RD"}, {"family": "Stoian", "given": "Anca Pantea", "initials": "AP"}, {"family": "Toth", "given": "Peter P", "initials": "PP"}, {"family": "Viswanathan", "given": "Vijay", "initials": "V"}, {"family": "Kempler", "given": "Peter", "initials": "P"}, {"family": "Rizzo", "given": "Manfredi", "initials": "M"}], "type": "journal article", "published": "2023-05-17", "journal": {"title": "Front Endocrinol (Lausanne)", "issn": "1664-2392", "issn-l": null, "volume": "14", "issue": null, "pages": "1129793"}, "abstract": "The past two decades have witnessed telemedicine becoming a crucial part of health care as a method to facilitate doctor-patient interaction. Due to technological developments and the incremental acquisition of experience in its use, telemedicine's advantages and cost-effectiveness has led to it being recognised as specifically relevant to diabetology. However, the pandemic created new challenges for healthcare systems and the rate of development of digital services started to grow exponentially. It was soon discovered that COVID-19-infected patients with diabetes had an increased risk of both mortality and debilitating sequelae. In addition, it was observed that this higher risk could be attenuated primarily by maintaining optimal control of the patient's glucose metabolism. As opportunities for actual physical doctor-patient visits became restricted, telemedicine provided the most convenient opportunity to communicate with patients and maintain delivery of care. The wide range of experiences of health care provision during the pandemic has led to the development of several excellent strategies regarding the applicability of telemedicine across the whole spectrum of diabetes care. The continuation of these strategies is likely to benefit clinical practice even after the pandemic crisis is over.", "doi": "10.3389/fendo.2023.1129793", "pmid": "37265696", "labels": {"Category: Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC10231679"}], "notes": [], "created": "2023-10-04T09:33:13.651Z", "modified": "2023-10-04T11:20:33.345Z"}, {"entity": "publication", "iuid": "316bc4a243ca4651b3b53d1cd380f377", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/316bc4a243ca4651b3b53d1cd380f377.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/316bc4a243ca4651b3b53d1cd380f377"}}, "title": "Ultra-Processed Food vs. Fruit and Vegetable Consumption before and during the COVID-19 Pandemic among Greek and Swedish Students.", "authors": [{"family": "Dhammawati", "given": "Friska", "initials": "F"}, {"family": "Fagerberg", "given": "Petter", "initials": "P"}, {"family": "Diou", "given": "Christos", "initials": "C", "orcid": "0000-0002-2461-1928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73e37fdd544145f7a09e5d09a91a3408.json"}}, {"family": "Mavrouli", "given": "Ioanna", "initials": "I"}, {"family": "Koukoula", "given": "Evangelia", "initials": "E"}, {"family": "Lekka", "given": "Eirini", "initials": "E"}, {"family": "Stefanopoulos", "given": "Leandros", "initials": "L", "orcid": "0000-0002-2682-5639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff30bac728204c79adb77b08c9f6c0bc.json"}}, {"family": "Maglaveras", "given": "Nicos", "initials": "N", "orcid": "0000-0002-4919-0664", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02ae3a48f10d4c60971b80f807381fe1.json"}}, {"family": "Heimeier", "given": "Rachel", "initials": "R", "orcid": "0000-0003-4798-1312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0e753a7fa1047a484f8abb065cda4a8.json"}}, {"family": "Karavidopoulou", "given": "Youla", "initials": "Y", "orcid": "0000-0003-3648-9533", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4df84c2905245249ae478b9fbb99124.json"}}, {"family": "Ioakimidis", "given": "Ioannis", "initials": "I"}], "type": "journal article", "published": "2023-05-16", "journal": {"title": "Nutrients", "issn": "2072-6643", "issn-l": null, "volume": "15", "issue": "10", "pages": null}, "abstract": "The COVID-19 pandemic has impacted children's lifestyles, including dietary behaviors. Of particular concern among these behaviors is the heightened prevalence of ultra-processed food (UPF) consumption, which has been linked to the development of obesity and related non-communicable diseases. The present study examines the changes in (1) UPF and (2) vegetable and/or fruit consumption among school-aged children in Greece and Sweden before and during the COVID-19 pandemic.\r\n\r\nThe analyzed dataset consisted of main meal pictures (breakfast, lunch, and dinner) captured by 226 Greek students (94 before the pandemic and 132 during the pandemic) and 421 Swedish students (293 before and 128 during the pandemic), aged 9-18, who voluntarily reported their meals using a mobile application. The meal pictures were collected over four-month periods over two consecutive years; namely, between the 20th of August and the 20th of December in 2019 (before the COVID-19 outbreak) and the same period in 2020 (during the COVID-19 outbreak). The collected pictures were annotated manually by a trained nutritionist. A chi-square test was performed to evaluate the differences in proportions before versus during the pandemic.\r\n\r\nIn total, 10,770 pictures were collected, including 6474 pictures from before the pandemic and 4296 pictures collected during the pandemic. Out of those, 86 pictures were excluded due to poor image quality, and 10,684 pictures were included in the final analyses (4267 pictures from Greece and 6417 pictures from Sweden). The proportion of UPF significantly decreased during vs. before the pandemic in both populations (50% vs. 46%, p = 0.010 in Greece, and 71% vs. 66%, p < 0.001 in Sweden), while the proportion of vegetables and/or fruits significantly increased in both cases (28% vs. 35%, p < 0.001 in Greece, and 38% vs. 42%, p = 0.019 in Sweden). There was a proportional increase in meal pictures containing UPF among boys in both countries. In Greece, both genders showed an increase in vegetables and/or fruits, whereas, in Sweden, the increase in fruit and/or vegetable consumption was solely observed among boys.\r\n\r\nThe proportion of UPF in the Greek and Swedish students' main meals decreased during the COVID-19 pandemic vs. before the pandemic, while the proportion of main meals with vegetables and/or fruits increased.", "doi": "10.3390/nu15102321", "pmid": "37242204", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10222979"}, {"db": "pii", "key": "nu15102321"}], "notes": [], "created": "2023-10-04T05:11:00.506Z", "modified": "2023-10-04T07:04:21.238Z"}, {"entity": "publication", "iuid": "1535d377dc0043e6915cc2128df2a520", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1535d377dc0043e6915cc2128df2a520.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1535d377dc0043e6915cc2128df2a520"}}, "title": "Cardiorespiratory dysautonomia in post-COVID-19 condition: Manifestations, mechanisms and management.", "authors": [{"family": "Fedorowski", "given": "Artur", "initials": "A"}, {"family": "Ols\u00e9n", "given": "Monika Fagevik", "initials": "MF"}, {"family": "Nikesj\u00f6", "given": "Frida", "initials": "F"}, {"family": "Janson", "given": "Christer", "initials": "C", "orcid": "0000-0001-5093-6980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba296cda8ef74430ad5457e71b7dae94.json"}}, {"family": "Bruchfeld", "given": "Judith", "initials": "J"}, {"family": "Lerm", "given": "Maria", "initials": "M", "orcid": "0000-0002-5092-9892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a326e1fb7efa4c4f8f59e7572f6b83bc.json"}}, {"family": "Hedman", "given": "Kristofer", "initials": "K", "orcid": "0000-0002-3751-7180", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30b778f33408413eaf0cce6023e9dfa3.json"}}], "type": "journal article", "published": "2023-05-14", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "A significant proportion of COVID-19 patients experience debilitating symptoms for months after the acute infection. According to recent estimates, approximately 1 out of 10 COVID-19 convalescents reports persistent health issues more than 3 months after initial recovery. This 'post-COVID-19 condition' may include a large variety of symptoms from almost all domains and organs, and for some patients it may mean prolonged sick-leave, homestay and strongly limited activities of daily life. In this narrative review, we focus on the symptoms and signs of post-COVID-19 condition in adults - particularly those associated with cardiovascular and respiratory systems, such as postural orthostatic tachycardia syndrome or airway disorders - and explore the evidence for chronic autonomic dysfunction as a potential underlying mechanism. The most plausible hypotheses regarding cellular and molecular mechanisms behind the wide spectrum of observed symptoms - such as lingering viruses, persistent inflammation, impairment in oxygen sensing systems and circulating antibodies directed to blood pressure regulatory components - are discussed. In addition, an overview of currently available pharmacological and non-pharmacological treatment options is presented.", "doi": "10.1111/joim.13652", "pmid": "37183186", "labels": {"Category: Post-COVID": null, "Type: Review": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:09:48.818Z", "modified": "2023-10-04T06:10:33.707Z"}, {"entity": "publication", "iuid": "721ff2ee08c24dc48b1f10b421760f89", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/721ff2ee08c24dc48b1f10b421760f89.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/721ff2ee08c24dc48b1f10b421760f89"}}, "title": "It turned into something else: patients' long-term experiences of transitions to or from telepsychotherapy during the COVID-19 pandemic.", "authors": [{"family": "von Below", "given": "Camilla", "initials": "C"}, {"family": "Bergsten", "given": "Jenny", "initials": "J"}, {"family": "Midbris", "given": "Ther\u00e9se", "initials": "T"}, {"family": "Philips", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Werbart", "given": "Andrzej", "initials": "A"}], "type": "journal article", "published": "2023-05-12", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "14", "issue": null, "pages": "1142233"}, "abstract": "The shift from in-person therapy to telepsychotherapy during the COVID-19 pandemic was unprepared for, sudden, and inevitable. This study explored patients' long-term experiences of transitions to telepsychotherapy and back to the office.\r\n\r\nData were collected approximately two years after the declaration of COVID-19 as a pandemic. Eleven patients were interviewed (nine women and two men, aged 28 to 56, six in psychodynamic psychotherapy, five in CBT). Treatments switched between in-person and video/telephone sessions. Interview transcripts were analyzed applying the qualitative methodology of inductive thematic analysis.\r\n\r\n(1) The patients experienced the process in telepsychotherapy as impeded. Interventions were difficult to understand and lost impact. Routines surrounding the therapy sessions were lost. Conversations were less serious and lost direction. (2) Understanding was made more difficult when the nuances of non-verbal communication were lost. (3) The emotional relationship was altered. Remote therapy was perceived as something different from regular therapy, and once back in the therapy room, the patients felt that therapy started anew. The emotional presence was experienced as weakened, but some of the patients found expressing their feelings easier in the absence of bodily co-presence. According to the patients, in-person presence contributed to their security and trust, whereas they felt that the therapists were different when working remotely, behaving in a more easygoing and familiar way, as well as more solution-focused, supportive and unprofessional, less understanding and less therapeutic. Despite this, (4) telepsychotherapy also gave the patients an opportunity to take therapy with them into their everyday lives.\r\n\r\nThe results suggest that in the long run, remote psychotherapy was seen as a good enough alternative when needed. The present study indicates that format alternations have an impact on which interventions can be implemented, which can have important implications for psychotherapy training and supervision in an era when telepsychotherapy is becoming increasingly common.", "doi": "10.3389/fpsyg.2023.1142233", "pmid": "37251023", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10213395"}], "notes": [], "created": "2023-10-04T05:11:38.740Z", "modified": "2023-10-04T07:17:13.780Z"}, {"entity": "publication", "iuid": "80b404bff0f7468b8e2191f370d09e8f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/80b404bff0f7468b8e2191f370d09e8f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/80b404bff0f7468b8e2191f370d09e8f"}}, "title": "A novel precision-serology assay for SARS-CoV-2 infection based on linear B-cell epitopes of Spike protein.", "authors": [{"family": "Lundin", "given": "Samuel B", "initials": "SB"}, {"family": "Kann", "given": "Hanna", "initials": "H"}, {"family": "Fulurija", "given": "Alma", "initials": "A"}, {"family": "Andersson", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Nakka", "given": "Sravya S", "initials": "SS"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "L"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Harandi", "given": "Ali M", "initials": "AM"}], "type": "journal article", "published": "2023-05-12", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "1166924"}, "abstract": "The COVID-19 pandemic illustrates the need for serology diagnostics with improved accuracy. While conventional serology based on recognition of entire proteins or subunits thereof has made significant contribution to the antibody assessment space, it often suffers from sub-optimal specificity. Epitope-based, high-precision, serology assays hold potential to capture the high specificity and diversity of the immune system, hence circumventing the cross-reactivity with closely related microbial antigens.\r\n\r\nWe herein report mapping of linear IgG and IgA antibody epitopes of the SARS-CoV-2 Spike (S) protein in samples from SARS-CoV-2 exposed individuals along with certified SARS-CoV-2 verification plasma samples using peptide arrays.\r\n\r\nWe identified 21 distinct linear epitopes. Importantly, we showed that pre-pandemic serum samples contain IgG antibodies reacting to the majority of protein S epitopes, most likely as a result of prior infection with seasonal coronaviruses. Only 4 of the identified SARS-CoV-2 protein S linear epitopes were specific for SARS-CoV-2 infection. These epitopes are located at positions 278-298 and 550-586, just proximal and distal to the RBD, as well as at position 1134-1156 in the HR2 subdomain and at 1248-1271 in the C-terminal subdomain of protein S. To substantiate the applicability of our findings, we tested three of the high-accuracy protein S epitopes in a Luminex assay, using a certified validation plasma sample set from SARS-CoV-2 infected individuals. The Luminex results were well aligned with the peptide array results, and correlated very well with in-house and commercial immune assays for RBD, S1 and S1/S2 domains of protein S.\r\n\r\nWe present a comprehensive mapping of linear B-cell epitopes of SARS-CoV-2 protein S, that identifies peptides suitable for a precision serology assay devoid of cross-reactivity. These results have implications for development of highly specific serology test for exposure to SARS-CoV-2 and other members of the coronaviridae family, as well as for rapid development of serology tests for future emerging pandemic threats.", "doi": "10.3389/fimmu.2023.1166924", "pmid": "37251407", "labels": {"Category: Proteins": null, "Funder: VR": null, "Funder: Vinnova": null, "Category: Serology": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC10213285"}], "notes": [], "created": "2023-10-04T05:08:59.564Z", "modified": "2023-10-04T05:52:28.750Z"}, {"entity": "publication", "iuid": "c5dbc692903546b79ffa2df414f5fcbf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5dbc692903546b79ffa2df414f5fcbf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5dbc692903546b79ffa2df414f5fcbf"}}, "title": "Validation of myocarditis diagnoses in the Swedish patient register for analyses of potential adverse reactions to COVID-19 vaccines.", "authors": [{"family": "Gedeborg", "given": "Rolf", "initials": "R"}, {"family": "Holm", "given": "Lennart", "initials": "L"}, {"family": "Feltelius", "given": "Nils", "initials": "N"}, {"family": "Sundstr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Eggers", "given": "Kai M", "initials": "KM"}, {"family": "Nurminen", "given": "Marja-Leena", "initials": "M"}, {"family": "Gr\u00fcnewald", "given": "Maria", "initials": "M"}, {"family": "Pihlstr\u00f6m", "given": "Nicklas", "initials": "N"}, {"family": "Zethelius", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Ljung", "given": "Rickard", "initials": "R"}], "type": "journal article", "published": "2023-05-11", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "issn-l": "0300-9734", "volume": "128", "issue": null, "pages": null}, "abstract": "Coronavirus disease 2019 (COVID-19) mRNA vaccines are associated with an increased risk of myocarditis using hospital discharge diagnoses as an outcome. The validity of these register-based diagnoses is uncertain.\r\n\r\nPatient records for subjects < 40 years of age and a diagnosis of myocarditis in the Swedish National Patient Register were manually reviewed. Brighton Collaboration diagnosis criteria for myocarditis were applied based on patient history, clinical examination, laboratory data, electrocardiograms, echocardiography, magnetic resonance imaging and myocardial biopsy. Poisson regression was used to estimate incidence rate ratios, comparing the register-based outcome variable to validated outcomes. Interrater reliability was assessed by a blinded re-evaluation.\r\n\r\nOverall, 95.6% (327/342) of cases registered as myocarditis were confirmed (definite, probable or possible myocarditis according to Brighton Collaboration diagnosis criteria, positive predictive value 0.96 [95% CI 0.93-0.98]). Of the 4.4% (15/342) cases reclassified as no myocarditis or as insufficient information, two cases had been exposed to the COVID-19 vaccine no more than 28 days before the myocarditis diagnosis, two cases were exposed >28 days before admission and 11 cases were unexposed to the vaccine. The reclassification had only minor impact on incidence rate ratios for myocarditis following COVID-19 vaccination. In total, 51 cases were sampled for a blinded re-evaluation. Of the 30 randomly sampled cases initially classified as either definite or probably myocarditis, none were re-classified after re-evaluation. Of the in all 15 cases initially classified as no myocarditis or insufficient information, 7 were after re-evaluation re-classified as probable or possible myocarditis. This re-classification was mostly due to substantial variability in electrocardiogram interpretation.\r\n\r\nThis validation of register-based diagnoses of myocarditis by manual patient record review confirmed the register diagnosis in 96% of cases and had high interrater reliability. Reclassification had only a minor impact on the incidence rate ratios for myocarditis following COVID-19 vaccination.", "doi": "10.48101/ujms.v128.9290", "pmid": "37223633", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10202079"}, {"db": "pii", "key": "9290"}], "notes": [], "created": "2023-10-04T05:10:23.710Z", "modified": "2023-10-04T06:36:38.159Z"}, {"entity": "publication", "iuid": "d2755f6aac6b4f11beef7264eb00f65d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d2755f6aac6b4f11beef7264eb00f65d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d2755f6aac6b4f11beef7264eb00f65d"}}, "title": "Social and moral psychology of COVID-19 across 69 countries.", "authors": [{"family": "Azevedo", "given": "Flavio", "initials": "F", "orcid": "0000-0001-9000-8513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7864cb0e9bf846d6b69a6a5bf65cbd91.json"}}, {"family": "Pavlovi\u0107", "given": "Tomislav", "initials": "T"}, {"family": "R\u00eago", "given": "Gabriel G", "initials": "GG"}, {"family": "Ay", "given": "F Ceren", "initials": "FC"}, {"family": "Gjoneska", "given": "Biljana", "initials": "B", "orcid": "0000-0003-1200-6672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37b6c574b4824a4eae77730b96814547.json"}}, {"family": "Etienne", "given": "Tom W", "initials": "TW"}, {"family": "Ross", "given": "Robert M", "initials": "RM", "orcid": "0000-0001-8711-1675", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49cb2e4d713844729ee7d64213f3cdbe.json"}}, {"family": "Sch\u00f6negger", "given": "Philipp", "initials": "P"}, {"family": "Ria\u00f1o-Moreno", "given": "Juli\u00e1n C", "initials": "JC"}, {"family": "Cichocka", "given": "Aleksandra", "initials": "A", "orcid": "0000-0003-1703-1586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0cc1202c8fb34d07952c7d99ab43bf87.json"}}, {"family": "Capraro", "given": "Valerio", "initials": "V"}, {"family": "Cian", "given": "Luca", "initials": "L"}, {"family": "Longoni", "given": "Chiara", "initials": "C"}, {"family": "Chan", "given": "Ho Fai", "initials": "HF", "orcid": "0000-0002-7281-5212", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f60a9007efb4abf8a952c375ea1abdf.json"}}, {"family": "Van Bavel", "given": "Jay J", "initials": "JJ", "orcid": "0000-0002-2520-0442", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/344fbd5da7bc4259b3f70839f401c84c.json"}}, {"family": "Sj\u00e5stad", "given": "Hallgeir", "initials": "H"}, {"family": "Nezlek", "given": "John B", "initials": "JB"}, {"family": "Alfano", "given": "Mark", "initials": "M"}, {"family": "Gelfand", "given": "Michele J", "initials": "MJ"}, {"family": "Birtel", "given": "Mich\u00e8le D", "initials": "MD"}, {"family": "Cislak", "given": "Aleksandra", "initials": "A"}, {"family": "Lockwood", "given": "Patricia L", "initials": "PL", "orcid": "0000-0001-7195-9559", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d77d4779b0ff456b906f2001dc3aa36f.json"}}, {"family": "Abts", "given": "Koen", "initials": "K"}, {"family": "Agadullina", "given": "Elena", "initials": "E"}, {"family": "Aruta", "given": "John Jamir Benzon", "initials": "JJB"}, {"family": "Besharati", "given": "Sahba Nomvula", "initials": "SN"}, {"family": "Bor", "given": "Alexander", "initials": "A", "orcid": "0000-0002-2624-9221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/048bdb252beb4b2599b619f41ace6277.json"}}, {"family": "Choma", "given": "Becky L", "initials": "BL"}, {"family": "Crabtree", "given": "Charles David", "initials": "CD", "orcid": "0000-0001-5144-8671", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4437f3c146f4f649e796f32d01d6052.json"}}, {"family": "Cunningham", "given": "William A", "initials": "WA"}, {"family": "De", "given": "Koustav", "initials": "K"}, {"family": "Ejaz", "given": "Waqas", "initials": "W"}, {"family": "Elbaek", "given": "Christian T", "initials": "CT", "orcid": "0000-0002-7039-4565", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a44f489ddccb4a208ec453424a471bfc.json"}}, {"family": "Findor", "given": "Andrej", "initials": "A"}, {"family": "Flichtentrei", "given": "Daniel", "initials": "D"}, {"family": "Franc", "given": "Renata", "initials": "R"}, {"family": "Gruber", "given": "June", "initials": "J"}, {"family": "Gualda", "given": "Estrella", "initials": "E"}, {"family": "Horiuchi", "given": "Yusaku", "initials": "Y", "orcid": "0000-0003-0295-4089", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f14d5ea8651405c879ccf113b4837da.json"}}, {"family": "Huynh", "given": "Toan Luu Duc", "initials": "TLD"}, {"family": "Ibanez", "given": "Agustin", "initials": "A", "orcid": "0000-0001-6758-5101", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4ec1841513243d981ba5cba471bc1d9.json"}}, {"family": "Imran", "given": "Mostak Ahamed", "initials": "MA"}, {"family": "Israelashvili", "given": "Jacob", "initials": "J"}, {"family": "Jasko", "given": "Katarzyna", "initials": "K"}, {"family": "Kantorowicz", "given": "Jaroslaw", "initials": "J", "orcid": "0000-0002-1186-5427", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/848df4a38f424410994e5c106185d6be.json"}}, {"family": "Kantorowicz-Reznichenko", "given": "Elena", "initials": "E"}, {"family": "Krouwel", "given": "Andr\u00e9", "initials": "A"}, {"family": "Laakasuo", "given": "Michael", "initials": "M"}, {"family": "Lamm", "given": "Claus", "initials": "C", "orcid": "0000-0002-5422-0653", "researcher": {"href": 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"A"}, {"family": "Otterbring", "given": "Tobias", "initials": "T", "orcid": "0000-0002-0283-8777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b90d29c347ca4fb49eb833460f190f7a.json"}}, {"family": "Packer", "given": "Dominic J", "initials": "DJ"}, {"family": "Perry", "given": "Anat", "initials": "A", "orcid": "0000-0003-2329-856X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b6a2128c1dc4cd5aad2dde7566aa37e.json"}}, {"family": "Petersen", "given": "Michael Bang", "initials": "MB"}, {"family": "Puthillam", "given": "Arathy", "initials": "A"}, {"family": "Rothmund", "given": "Tobias", "initials": "T", "orcid": "0000-0003-2979-5129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96685e8f4755437b81d7e1d41381312d.json"}}, {"family": "Santamar\u00eda-Garc\u00eda", "given": "Hernando", "initials": "H"}, {"family": "Schmid", "given": "Petra C", "initials": "PC", "orcid": "0000-0002-9990-5445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f24dbb2b28c44881b862a94f9c6d59e4.json"}}, {"family": "Stoyanov", "given": "Drozdstoy", "initials": "D"}, {"family": "Tewari", "given": "Shruti", "initials": "S"}, {"family": "Todosijevi\u0107", "given": "Bojan", "initials": "B", "orcid": "0000-0002-6116-993X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bed2094110af4e1aa6d4d879c0191924.json"}}, {"family": "Tsakiris", "given": "Manos", "initials": "M"}, {"family": "Tung", "given": "Hans H", "initials": "HH", "orcid": "0000-0001-5332-7582", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90faa443e86948479e05007a0abf5f13.json"}}, {"family": "Umbres", "given": "Radu G", "initials": "RG"}, {"family": "Vanags", "given": "Edmunds", "initials": "E"}, {"family": "Vlasceanu", "given": "Madalina", "initials": "M"}, {"family": "Vonasch", "given": "Andrew", "initials": "A"}, {"family": "Yucel", "given": "Meltem", "initials": "M", "orcid": "0000-0002-7274-5971", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65a44c75ffa1499abea1909977b44e79.json"}}, {"family": "Zhang", "given": "Yucheng", "initials": "Y"}, {"family": "Abad", "given": "Mohcine", "initials": "M"}, {"family": "Adler", "given": "Eli", "initials": "E"}, {"family": "Akrawi", "given": "Narin", "initials": "N"}, {"family": "Mdarhri", "given": "Hamza Alaoui", "initials": "HA"}, {"family": "Amara", "given": "Hanane", "initials": "H"}, {"family": "Amodio", "given": "David M", "initials": "DM"}, {"family": "Antazo", "given": "Benedict G", "initials": "BG"}, {"family": "Apps", "given": "Matthew", "initials": "M"}, {"family": "Ba", "given": "Mouhamadou Hady", "initials": "MH"}, {"family": "Barbosa", "given": "Sergio", "initials": "S"}, {"family": "Bastian", "given": "Brock", "initials": "B"}, {"family": "Berg", "given": "Anton", "initials": "A", "orcid": "0000-0001-7143-762X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f6b2a7c6d0041b39f6a77356b47eca6.json"}}, {"family": "Bernal-Z\u00e1rate", "given": "Maria P", "initials": "MP"}, {"family": "Bernstein", "given": "Michael", "initials": "M"}, {"family": "Bia\u0142ek", "given": "Micha\u0142", "initials": "M", "orcid": "0000-0002-5062-5733", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd43a7a8fd0b465cb56c23de434f04a6.json"}}, {"family": "Bilancini", "given": "Ennio", "initials": "E"}, {"family": "Bogatyreva", "given": "Natalia", "initials": "N"}, {"family": "Boncinelli", "given": "Leonardo", "initials": "L"}, {"family": "Booth", "given": "Jonathan E", "initials": "JE"}, {"family": "Borau", "given": "Sylvie", "initials": "S"}, {"family": "Buchel", "given": "Ondrej", "initials": "O"}, {"family": "Cameron", "given": "C Daryl", "initials": "CD"}, {"family": "Carvalho", "given": "Chrissie F", "initials": "CF"}, {"family": "Celadin", "given": "Tatiana", "initials": "T"}, {"family": "Cerami", "given": "Chiara", "initials": "C"}, {"family": "Chalise", "given": "Hom Nath", "initials": "HN"}, {"family": "Cheng", "given": "Xiaojun", "initials": "X"}, {"family": "Cockcroft", "given": "Kate", "initials": "K"}, {"family": "Conway", "given": "Jane", "initials": "J"}, {"family": "C\u00f3rdoba-Delgado", "given": "Mateo Andres", "initials": "MA"}, {"family": "Crespi", "given": "Chiara", "initials": "C"}, {"family": "Crouzevialle", "given": "Marie", "initials": "M"}, {"family": "Cutler", "given": "Jo", "initials": "J", "orcid": "0000-0003-1073-764X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82741a7a79b4480e8f352876ef8387a3.json"}}, {"family": "Cyprya\u0144ska", "given": "Marzena", "initials": "M"}, {"family": "Dabrowska", "given": "Justyna", "initials": "J"}, {"family": "Daniels", "given": "Michael A", "initials": "MA"}, {"family": "Davis", "given": "Victoria H", "initials": "VH"}, {"family": "Dayley", "given": "Pamala N", "initials": "PN"}, {"family": "Delouv\u00e9e", "given": "Sylvain", "initials": "S"}, {"family": "Denkovski", "given": "Ognjan", "initials": "O"}, {"family": "Dezecache", "given": "Guillaume", "initials": "G"}, {"family": "Dhaliwal", "given": "Nathan A", "initials": "NA"}, {"family": "Diato", "given": "Alelie B", "initials": "AB"}, {"family": "Di Paolo", "given": "Roberto", "initials": "R", "orcid": "0000-0002-6081-6656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8d2c283668e45ca8aed107a3db0ef8c.json"}}, {"family": "Drosinou", "given": "Marianna", "initials": "M"}, {"family": "Dulleck", "given": "Uwe", "initials": "U", "orcid": "0000-0002-0953-5963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ae9e80682d041518c3ae2f05aec127b.json"}}, {"family": "Ekmanis", "given": "J\u0101nis", "initials": "J"}, {"family": "Ertan", "given": "Arhan S", "initials": "AS", "orcid": "0000-0001-9730-8391", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/459a43a3f47548c3a73d95dbba35127e.json"}}, {"family": "Farhana", "given": "Hapsa Hossain", "initials": "HH"}, {"family": "Farkhari", "given": "Fahima", "initials": "F"}, {"family": "Farmer", "given": "Harry", "initials": "H"}, {"family": "Fenwick", "given": "Ali", "initials": "A"}, {"family": "Fidanovski", "given": "Kristijan", "initials": "K"}, {"family": "Flew", "given": "Terry", "initials": "T", "orcid": "0000-0003-4485-9338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42e85004785b47bdb832a1fd244200ec.json"}}, {"family": "Fraser", "given": "Shona", "initials": "S"}, {"family": "Frempong", "given": "Raymond Boadi", "initials": "RB", "orcid": "0000-0002-4603-5570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab32089980fe487a8e6d86e359f8d030.json"}}, {"family": "Fugelsang", "given": "Jonathan A", "initials": "JA"}, {"family": "Gale", "given": "Jessica", "initials": "J"}, {"family": "Garcia-Navarro", "given": "E Bego\u00f1a", "initials": "EB"}, {"family": "Garladinne", "given": "Prasad", "initials": "P"}, {"family": "Ghajjou", "given": "Oussama", "initials": "O"}, {"family": "Gkinopoulos", "given": "Theofilos", "initials": "T"}, {"family": "Gray", "given": "Kurt", "initials": "K", "orcid": "0000-0001-5816-2676", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67471907cc074b69a912d7d08c0b04da.json"}}, {"family": "Griffin", "given": "Siobh\u00e1n M", "initials": "SM", "orcid": "0000-0002-3613-2844", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31c574cb243e4e5a9bce1c3e243db028.json"}}, {"family": "Gronfeldt", "given": "Bjarki", "initials": "B"}, {"family": "G\u00fcmren", "given": "Mert", "initials": "M"}, {"family": "Gurung", "given": "Ranju Lama", "initials": "RL"}, {"family": "Halperin", "given": "Eran", "initials": "E"}, {"family": "Harris", "given": "Elizabeth", "initials": "E"}, {"family": "Herzon", "given": "Volo", "initials": "V"}, {"family": "Hru\u0161ka", "given": "Matej", "initials": "M"}, {"family": "Huang", "given": "Guanxiong", "initials": "G"}, {"family": "Hudecek", "given": "Matthias F C", "initials": "MFC"}, {"family": "Isler", "given": "Ozan", "initials": "O"}, {"family": "Jangard", "given": "Simon", "initials": "S"}, {"family": "Jorgensen", "given": "Frederik J", "initials": "FJ"}, {"family": "Kachanoff", "given": "Frank", "initials": "F"}, {"family": "Kahn", "given": "John", "initials": "J"}, {"family": "Dangol", "given": "Apsara Katuwal", "initials": "AK"}, {"family": "Keudel", "given": "Oleksandra", "initials": "O"}, {"family": "Koppel", "given": "Lina", "initials": "L"}, {"family": "Koverola", "given": "Mika", "initials": "M"}, {"family": "Kubin", "given": "Emily", "initials": "E"}, {"family": "Kunnari", "given": "Anton", "initials": "A"}, {"family": "Kutiyski", "given": "Yordan", "initials": "Y"}, {"family": "Laguna", "given": "Oscar Moreda", "initials": "OM"}, {"family": "Leota", "given": "Josh", "initials": "J"}, {"family": "Lermer", "given": "Eva", "initials": "E", "orcid": "0000-0002-6600-9580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8718588bed3b426c8f3582013e2bde9a.json"}}, {"family": "Levy", "given": "Jonathan", "initials": "J"}, {"family": "Levy", "given": "Neil", "initials": "N"}, {"family": "Li", "given": "Chunyun", "initials": "C"}, {"family": "Long", "given": "Elizabeth U", "initials": "EU"}, {"family": "Magli\u0107", "given": "Marina", "initials": "M", "orcid": "0000-0002-6851-4601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d8c351f3a484c3690ba0fa55f7cebdb.json"}}, {"family": "McCashin", "given": "Darragh", "initials": "D"}, {"family": "Metcalf", "given": "Alexander L", "initials": "AL"}, {"family": "Miklou\u0161i\u0107", "given": "Igor", "initials": "I"}, {"family": "El Mimouni", "given": "Soulaimane", "initials": "S"}, {"family": "Miura", "given": "Asako", "initials": "A"}, {"family": "Molina-Paredes", "given": "Juliana", "initials": "J"}, {"family": "Monroy-Fonseca", "given": "C\u00e9sar", "initials": "C", "orcid": "0000-0003-4696-8159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/715e7e9db3b04bd58083903c33f909ca.json"}}, {"family": "Morales-Marente", "given": "Elena", "initials": "E"}, {"family": "Moreau", "given": "David", "initials": "D"}, {"family": "Muda", "given": "Rafa\u0142", "initials": "R"}, {"family": "Myer", "given": "Annalisa", "initials": "A"}, {"family": "Nash", "given": "Kyle", "initials": "K"}, {"family": "Nesh-Nash", "given": "Tarik", "initials": "T"}, {"family": "Nitschke", "given": "Jonas P", "initials": "JP"}, {"family": "Nurse", "given": "Matthew S", "initials": "MS"}, {"family": "Ohtsubo", "given": "Yohsuke", "initials": "Y"}, {"family": "de Mello", "given": "Victoria Oldemburgo", "initials": "VO"}, {"family": "O'Madagain", "given": "Cathal", "initials": "C"}, {"family": "Onderco", "given": "Michal", "initials": "M"}, {"family": "Palacios-Galvez", "given": "M Soledad", "initials": "MS"}, {"family": "Palom\u00f6ki", "given": "Jussi", "initials": "J"}, {"family": "Pan", "given": "Yafeng", "initials": "Y", "orcid": "0000-0002-5633-8313", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11ad1f48e9064fdea87ca96243bbc3f2.json"}}, {"family": "Papp", "given": "Zs\u00f3fia", "initials": "Z", "orcid": "0000-0001-6257-0568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5bb5540338b94b97b0aa6e9fead937d9.json"}}, {"family": "P\u00e4rnamets", "given": "Philip", "initials": "P", "orcid": "0000-0001-8360-9097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba8ef195b1bc4137be457fd7c81fd8dc.json"}}, {"family": "Paruzel-Czachura", "given": "Mariola", "initials": "M"}, {"family": "Pavlovi\u0107", "given": "Zoran", "initials": "Z"}, {"family": "Pay\u00e1n-G\u00f3mez", "given": "C\u00e9sar", "initials": "C"}, {"family": "Perander", "given": "Silva", "initials": "S"}, {"family": "Pitman", "given": "Michael Mark", "initials": "MM"}, {"family": "Prasad", "given": "Rajib", "initials": "R"}, {"family": "Pyrkosz-Pacyna", "given": "Joanna", "initials": "J"}, {"family": "Rathje", "given": "Steve", "initials": "S"}, {"family": "Raza", "given": "Ali", "initials": "A"}, {"family": "Rhee", "given": "Kasey", "initials": "K"}, {"family": "Robertson", "given": "Claire E", "initials": "CE"}, {"family": "Rodr\u00edguez-Pascual", "given": "Iv\u00e1n", "initials": "I"}, {"family": "Saikkonen", "given": "Teemu", "initials": "T"}, {"family": "Salvador-Ginez", "given": "Octavio", "initials": "O"}, {"family": "Santi", "given": "Gaia C", "initials": "GC"}, {"family": "Santiago-Tovar", "given": "Natalia", "initials": "N"}, {"family": "Savage", "given": "David", "initials": "D"}, {"family": "Scheffer", "given": "Julian A", "initials": "JA"}, {"family": "Schultner", "given": "David T", "initials": "DT"}, {"family": "Schutte", "given": "Enid M", "initials": "EM"}, {"family": "Scott", "given": "Andy", "initials": "A"}, {"family": "Sharma", "given": "Madhavi", "initials": "M"}, {"family": "Sharma", "given": "Pujan", "initials": "P"}, {"family": "Skali", "given": "Ahmed", "initials": "A"}, {"family": "Stadelmann", "given": "David", "initials": "D"}, {"family": "Stafford", "given": "Clara Alexandra", "initials": "CA"}, {"family": "Stanojevi\u0107", "given": "Dragan", "initials": "D"}, {"family": "Stefaniak", "given": "Anna", "initials": "A"}, {"family": "Sternisko", "given": "Anni", "initials": "A"}, {"family": "Stoica", "given": "Augustin", "initials": "A"}, {"family": "Stoyanova", "given": "Kristina K", "initials": "KK"}, {"family": "Strickland", "given": "Brent", "initials": "B"}, {"family": "Sundvall", "given": "Jukka", "initials": "J"}, {"family": "Thomas", "given": "Jeffrey P", "initials": "JP"}, {"family": "Tingh\u00f6g", "given": "Gustav", "initials": "G"}, {"family": "Torgler", "given": "Benno", "initials": "B", "orcid": "0000-0002-9809-963X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9cfc75344e74113bcd7b709ebd5566e.json"}}, {"family": "Traast", "given": "Iris J", "initials": "IJ"}, {"family": "Tucciarelli", "given": "Raffaele", "initials": "R"}, {"family": "Tyrala", "given": "Michael", "initials": "M"}, {"family": "Ungson", "given": "Nick D", "initials": "ND"}, {"family": "Uysal", "given": "Mete S", "initials": "MS"}, {"family": "Van Lange", "given": "Paul A M", "initials": "PAM", "orcid": "0000-0001-7774-6984", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14e8d477999b4beb9878beb5f7ee3e99.json"}}, {"family": "van Prooijen", "given": "Jan-Willem", "initials": "J"}, {"family": "van Rooy", "given": "Dirk", "initials": "D"}, {"family": "V\u00e4stfj\u00e4ll", "given": "Daniel", "initials": "D"}, {"family": "Verkoeijen", "given": "Peter", "initials": "P"}, {"family": "Vieira", "given": "Joana B", "initials": "JB"}, {"family": "von Sikorski", "given": "Christian", "initials": "C"}, {"family": "Walker", "given": "Alexander Cameron", "initials": "AC"}, {"family": "Watermeyer", "given": "Jennifer", "initials": "J"}, {"family": "Wetter", "given": "Erik", "initials": "E"}, {"family": "Whillans", "given": "Ashley", "initials": "A"}, {"family": "White", "given": "Katherine", "initials": "K"}, {"family": "Habib", "given": "Rishad", "initials": "R"}, {"family": "Willardt", "given": "Robin", "initials": "R"}, {"family": "Wohl", "given": "Michael J A", "initials": "MJA"}, {"family": "W\u00f3jcik", "given": "Adrian Dominik", "initials": "AD", "orcid": "0000-0002-7073-6019", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b96aa00cd81f466599febb11c10a3a99.json"}}, {"family": "Wu", "given": "Kaidi", "initials": "K"}, {"family": "Yamada", "given": "Yuki", "initials": "Y", "orcid": "0000-0003-1431-568X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12d5285132e14b7bbca2607a084fb449.json"}}, {"family": "Yilmaz", "given": "Onurcan", "initials": "O"}, {"family": "Yogeeswaran", "given": "Kumar", "initials": "K", "orcid": "0000-0002-1978-5077", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ef06acca6df4009bd0ab178af33551b.json"}}, {"family": "Ziemer", "given": "Carolin-Theresa", "initials": "C"}, {"family": "Zwaan", "given": "Rolf A", "initials": "RA"}, {"family": "Boggio", "given": "Paulo S", "initials": "PS"}, {"family": "Sampaio", "given": "Waldir M", "initials": "WM", "orcid": "0000-0002-6066-4314", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/003b9727584c4c2bb054a6ed2448c809.json"}}], "type": "dataset", "published": "2023-05-11", "journal": {"title": "Sci Data", "issn": "2052-4463", "issn-l": null, "volume": "10", "issue": "1", "pages": "272"}, "abstract": "The COVID-19 pandemic has affected all domains of human life, including the economic and social fabric of societies. One of the central strategies for managing public health throughout the pandemic has been through persuasive messaging and collective behaviour change. To help scholars better understand the social and moral psychology behind public health behaviour, we present a dataset comprising of 51,404 individuals from 69 countries. This dataset was collected for the International Collaboration on Social & Moral Psychology of COVID-19 project (ICSMP COVID-19). This social science survey invited participants around the world to complete a series of moral and psychological measures and public health attitudes about COVID-19 during an early phase of the COVID-19 pandemic (between April and June 2020). The survey included seven broad categories of questions: COVID-19 beliefs and compliance behaviours; identity and social attitudes; ideology; health and well-being; moral beliefs and motivation; personality traits; and demographic variables. We report both raw and cleaned data, along with all survey materials, data visualisations, and psychometric evaluations of key variables.", "doi": "10.1038/s41597-023-02080-8", "pmid": "37169799", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10173241"}, {"db": "pii", "key": "10.1038/s41597-023-02080-8"}], "notes": [], "created": "2023-10-04T05:10:30.964Z", "modified": "2023-10-04T06:44:19.514Z"}, {"entity": "publication", "iuid": "fc726a79a3c0468087e48d2b34902664", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc726a79a3c0468087e48d2b34902664.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc726a79a3c0468087e48d2b34902664"}}, "title": "Current tobacco use and SARS-CoV-2 infection in two Norwegian population-based cohorts.", "authors": [{"family": "Caspersen", "given": "Ida Henriette", "initials": "IH"}, {"family": "Trogstad", "given": "Lill", "initials": "L"}, {"family": "Galanti", "given": "Maria Rosaria", "initials": "MR"}, {"family": "Karvonen", "given": "Sakari", "initials": "S"}, {"family": "Pe\u00f1a", "given": "Sebasti\u00e1n", "initials": "S"}, {"family": "Shaaban", "given": "Ahmed Nabil", "initials": "AN"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}, {"family": "Magnus", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2023-05-10", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "23", "issue": "1", "pages": "846"}, "abstract": "Clear evidence of an increased risk for SARS-CoV-2 infection among smokers has not been established. We aimed to investigate associations between cigarette smoking or use of snus (snuff) and other nicotine-containing products and a positive SARS-CoV-2 test, taking test behavior into account.\r\n\r\nCurrent tobacco use and testing behavior during the pandemic were recorded by adult participants from the Norwegian Mother, Father and Child Cohort Study and The Norwegian Influenza Pregnancy Cohort. SARS-CoV-2 infection status was obtained from The Norwegian Surveillance System for Communicable Diseases (MSIS) in May 2021 (n = 78,860) and antibody measurements (n = 5581). We used logistic regression models stratified by gender and adjusted for age, education, region, number of household members, and work situation.\r\n\r\nSnus use was more common among men (26%) than women (9%) and more prevalent than cigarette smoking. We found no clear associations between cigarette smoking or snus and a COVID-19 diagnosis among men. Associations among women were conflicting, indicating that cigarette smoke was negatively associated with a diagnosis (OR 0.51, 95% CI 0.35, 0.75), while no association was found for snus use (OR 1.07, 95% CI 0.86, 1.34). Compared with non-users of tobacco, both cigarette smokers and snus users had increased odds of being tested for SARS-CoV-2.\r\n\r\nCigarette smoking, but not snus use, was negatively associated with SARS-CoV-2 infection in women. The lack of an association between snus use and SARS-CoV-2 infection in this population with prevalent snus use does not support the hypothesis of a protective effect of nicotine.", "doi": "10.1186/s12889-023-15822-5", "pmid": "37165385", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10170041"}, {"db": "pii", "key": "10.1186/s12889-023-15822-5"}], "notes": [], "created": "2023-10-04T05:08:57.146Z", "modified": "2023-10-04T05:50:44.009Z"}, {"entity": "publication", "iuid": "34b32b64758d4e9eb5e573fc545c5bbf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/34b32b64758d4e9eb5e573fc545c5bbf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/34b32b64758d4e9eb5e573fc545c5bbf"}}, "title": "Articulations of 'Funeral' in Swedish Newspapers During the Covid-19 Pandemic.", "authors": [{"family": "Jarnkvist", "given": "Karin", "initials": "K", "orcid": "0000-0002-6408-2952", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3418f7feda5247efae3f9bb8c785a6e3.json"}}], "type": "journal article", "published": "2023-05-10", "journal": {"title": "Omega (Westport)", "issn": "1541-3764", "issn-l": null, "volume": null, "issue": null, "pages": "302228231174601"}, "abstract": "This article explores how 'funeral' was articulated in Swedish newspapers during the Covid-19 pandemic and how such articulations relate to power and ideology. Articles from the six most prominent Swedish newspapers, published over 2 years, have been analyzed using critical discourse analysis and intersectionality. The study reveals three funeral discourses dominating during different periods of the pandemic: 'Funeral as a risk,' 'Funeral as an essential ritual,' and 'Funeral as a profession.' Altogether, the three discourses expose an ideal of 'the responsible mourner.' This rational woman follows the funeral restrictions and arranges a church funeral shortly after the death of a relative. The 'good funeral' is portrayed as a church funeral with physically present mourners, performed according to the deceased's will and in honor of the dead. The 'bad funeral,' described as the opposite of the 'good funeral,' dominates the understanding of the pandemic funeral situation.", "doi": "10.1177/00302228231174601", "pmid": "37165654", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:11:36.308Z", "modified": "2023-10-04T07:15:59.305Z"}, {"entity": "publication", "iuid": "1fc932cb2ce44153aa4bb828ae2ebc7d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1fc932cb2ce44153aa4bb828ae2ebc7d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1fc932cb2ce44153aa4bb828ae2ebc7d"}}, "title": "Mucosal immunization with lactiplantibacillus plantarum-displaying recombinant SARS-CoV-2 epitopes on the surface induces humoral and mucosal immune responses in mice.", "authors": [{"family": "Hwang", "given": "In-Chan", "initials": "I"}, {"family": "Valeriano", "given": "Valerie Diane", "initials": "VD"}, {"family": "Song", "given": "Ji Hoon", "initials": "JH"}, {"family": "Pereira", "given": "Marcela", "initials": "M"}, {"family": "Oh", "given": "Ju Kyoung", "initials": "JK"}, {"family": "Han", "given": "Kyudong", "initials": "K"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Kang", "given": "Dae-Kyung", "initials": "D"}], "type": "journal article", "published": "2023-05-09", "journal": {"title": "Microb Cell Fact", "issn": "1475-2859", "issn-l": null, "volume": "22", "issue": "1", "pages": "96"}, "abstract": "The use of probiotic lactic acid bacteria as a mucosal vaccine vector is considered a promising alternative compared to the use of other microorganisms because of its \"Generally Regarded as Safe\" status, its potential adjuvant properties, and its tolerogenicity to the host. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease (COVID-19), is highly transmissible and pathogenic. This study aimed to determine the potential of Lactiplantibacillus plantarum expressing SARS-CoV-2 epitopes as a mucosal vaccine against SARS-CoV-2.\r\n\r\nIn this study, the possible antigenic determinants of the spike (S1-1, S1-2, S1-3, and S1-4), membrane (ME1 and ME2), and envelope (E) proteins of SARS-CoV-2 were predicted, and recombinant L. plantarum strains surface-displaying these epitopes were constructed. Subsequently, the immune responses induced by these recombinant strains were compared in vitro and in vivo. Most surface-displayed epitopes induced pro-inflammatory cytokines [tumor necrosis factor alpha (TNF-\u03b1 and interleukin (IL)-6] and anti-inflammatory cytokines (IL-10) in lipopolysaccharide-induced RAW 264.7, with the highest anti-inflammatory to pro-inflammatory cytokine ratio in the S1-1 and S1-2 groups, followed by that in the S1-3 group. When orally administered of recombinant L. plantarum expressing SARS-CoV-2 epitopes in mice, all epitopes most increased the expression of IL-4, along with induced levels of TNF-\u03b1, interferon-gamma, and IL-10, specifically in spike protein groups. Thus, the surface expression of epitopes from the spike S1 protein in L. plantarum showed potential immunoregulatory effects, suggesting its ability to potentially circumvent hyperinflammatory states relevant to monocyte/macrophage cell activation. At 35 days post immunization (dpi), serum IgG levels showed a marked increase in the S1-1, S1-2, and S1-3 groups. Fecal IgA levels increased significantly from 21 dpi in all the antigen groups, but the boosting effect after 35 dpi was explicitly observed in the S1-1, S1-2, and S1-3 groups. Thus, the oral administration of SARS-CoV-2 antigens into mice induced significant humoral and mucosal immune responses.\r\n\r\nThis study suggests that L. plantarum is a potential vector that can effectively deliver SARS-CoV-2 epitopes to intestinal mucosal sites and could serve as a novel approach for SARS-CoV-2 mucosal vaccine development.", "doi": "10.1186/s12934-023-02100-7", "pmid": "37161468", "labels": {"Funder: VR": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10169176"}, {"db": "pii", "key": "10.1186/s12934-023-02100-7"}], "notes": [], "created": "2023-10-04T05:09:02.049Z", "modified": "2023-10-04T05:54:36.250Z"}, {"entity": "publication", "iuid": "5dd3c0e88dc24abe95c6c5328fec4d23", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5dd3c0e88dc24abe95c6c5328fec4d23.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5dd3c0e88dc24abe95c6c5328fec4d23"}}, "title": "Vaccine effectiveness of BNT162b2 mRNA Covid-19 Vaccine in Children below 5 Years in German Primary Care", "authors": [{"family": "Strumann", "given": "Christoph", "initials": "C", "orcid": "0000-0003-2725-6543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ea86e19543e4c0bb8ff7820e029fb1e.json"}}, {"family": "Ranzani", "given": "Otavio", "initials": "O", "orcid": "0000-0002-4677-6862", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/891f1de2767b44efbca8b6e7f5e18874.json"}}, {"family": "Moor", "given": "Jeanne", "initials": "J"}, {"family": "Berner", "given": "Reinhard", "initials": "R", "orcid": "0000-0002-6216-9173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2afcdc91e9424d9285eeb1526874c18b.json"}}, {"family": "T\u00f6pfner", "given": "Nicole", "initials": "N", "orcid": "0000-0002-9693-4419", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8c908b0701b4c6b9fb6e26acb479b8f.json"}}, {"family": "Chao", "given": "Cho Ming", "initials": "CM", "orcid": "0000-0002-0034-8264", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e1c91c06f144eb5bfca0a7126b69e11.json"}}, {"family": "Moor", "given": "Matthias B", "initials": "MB", "orcid": "0000-0002-7717-651X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01cf6b66149b43339c7a79fde358b702.json"}}], "type": "posted-content", "published": "2023-05-08", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.05.05.23289209", "pmid": null, "labels": {"Type: Preprint": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:11:59.151Z", "modified": "2023-10-04T07:25:20.770Z"}, {"entity": "publication", "iuid": "cfbc4759b84b4935802122112005ce87", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfbc4759b84b4935802122112005ce87.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfbc4759b84b4935802122112005ce87"}}, "title": "Vaccine-induced correlate of protection against fatal COVID-19 in older and frail adults during waves of neutralization-resistant variants of concern: an observational study.", "authors": [{"family": "Vikstr\u00f6m", "given": "Linnea", "initials": "L"}, {"family": "Fj\u00e4llstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Gwon", "given": "Yong-Dae", "initials": "Y"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Wigren-Bystr\u00f6m", "given": "Julia", "initials": "J"}, {"family": "Evander", "given": "Magnus", "initials": "M"}, {"family": "Bladh", "given": "Oscar", "initials": "O"}, {"family": "Widerstr\u00f6m", "given": "Micael", "initials": "M"}, {"family": "Molnar", "given": "Christian", "initials": "C"}, {"family": "Rasmussen", "given": "Gunl\u00f6g", "initials": "G"}, {"family": "Bennet", "given": "Louise", "initials": "L"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}, {"family": "Tevell", "given": "Staffan", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}], "type": "journal article", "published": "2023-05-06", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "issn-l": null, "volume": "30", "issue": null, "pages": "100646"}, "abstract": "To inform future preventive measures including repeated vaccinations, we have searched for a clinically useful immune correlate of protection against fatal COVID-19 among nursing homes residents.\r\n\r\nWe performed repeated capillary blood sampling with analysis of S-binding IgG in an open cohort of nursing home residents in Sweden. We analyzed immunological and registry data from 16 September 2021 to 31 August 2022 with follow-up of deaths to 30 September 2022. The study period included implementation of the 3rd and 4th mRNA monovalent vaccine doses and Omicron virus waves.\r\n\r\nA total of 3012 nursing home residents with median age 86 were enrolled. The 3rd mRNA dose elicited a 99-fold relative increase of S-binding IgG in blood and corresponding increase of neutralizing antibodies. The 4th mRNA vaccine dose boosted levels 3.8-fold. Half-life of S-binding IgG was 72 days. A total 528 residents acquired their first SARS-CoV-2 infection after the 3rd or the 4th vaccine dose and the associated 30-day mortality was 9.1%. We found no indication that levels of vaccine-induced antibodies protected against infection with Omicron VOCs. In contrast, the risk of death was inversely correlated to levels of S-directed IgG below the 20th percentile. The death risk plateaued at population average above the lower 35th percentile of S-binding IgG.\r\n\r\nIn the absence of neutralizing antibodies that protect from infection, quantification of S-binding IgG post vaccination may be useful to identify the most vulnerable for fatal COVID-19 among the oldest and frailest. This information is of importance for future strategies to protect vulnerable populations against neutralization resistant variants of concern.\r\n\r\nSwedish Research Council, SciLifeLab via Knut and Alice Wallenberg Foundation, VINNOVA. Swedish Healthcare Regions, and Erling Persson Foundation.", "doi": "10.1016/j.lanepe.2023.100646", "pmid": "37363799", "labels": {"Funder: VR": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10163377"}, {"db": "pii", "key": "S2666-7762(23)00065-0"}], "notes": [], "created": "2023-07-13T11:35:27.330Z", "modified": "2023-10-04T10:01:29.263Z"}, {"entity": "publication", "iuid": "8ad583f7951244339eefca386b4d8b31", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ad583f7951244339eefca386b4d8b31.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ad583f7951244339eefca386b4d8b31"}}, "title": "Knowledge and attitudes toward COVID-19 vaccination in Sudan: A cross-sectional study.", "authors": [{"family": "Badi", "given": "Safaa", "initials": "S"}, {"family": "Babiker", "given": "Loai Abdelgadir", "initials": "LA"}, {"family": "Aldow", "given": "Abdullah Yasseen", "initials": "AY"}, {"family": "Abas", "given": "Almigdad Badr Aldeen", "initials": "ABA"}, {"family": "Eisa", "given": "Mazen Abdelhafiez", "initials": "MA"}, {"family": "Abu-Ali", "given": "Mohamed Nour", "initials": "MN"}, {"family": "Abdella", "given": "Wagass Abdelrhman", "initials": "WA"}, {"family": "Marzouq", "given": "Mohamed Elsir", "initials": "ME"}, {"family": "Ahmed", "given": "Musaab", "initials": "M"}, {"family": "Omer", "given": "Abubakr Ali M", "initials": "AAM"}, {"family": "Ahmed", "given": "Mohamed H", "initials": "MH"}], "type": "journal article", "published": "2023-05-06", "journal": {"title": "AIMS Public Health", "issn": "2327-8994", "issn-l": null, "volume": "10", "issue": "2", "pages": "310-323"}, "abstract": "Vaccines are an essential part of public health interventions to mitigate the devastating health and non-health impacts of COVID-19 pandemic. Despite the fact that Sudan launched the COVID-19 vaccination program in March 2021, only 10% of the population received their two primary doses of vaccines by the end of May 2022. This delayed uptake of vaccines obviously warrants investigation. Therefore, we have conducted this study to evaluate the knowledge, attitude and acceptance of the general population in Sudan toward COVID-19 vaccines.\r\n\r\nA descriptive cross-sectional community-based study. The data were collected using an electronic questionnaire from 403 individuals living in Khartoum, Sudan. The data were processed using the Statistical Package for Social Sciences (SPSS), and data analysis was performed using appropriate tests.\r\n\r\n51% of the participants were found to have sufficient knowledge about the COVID-19 vaccine, and the knowledge level is higher among those educated beyond the secondary school and those who were employed. Among those unvaccinated, only 47% of the participants expressed their intention to take the vaccine when offered to them. The major reason for not trusting the vaccine is safety concerns expressed by 65.5% of the unvaccinated.\r\n\r\nHigher education levels and employment were associated with an increase in sufficient knowledge about the vaccine in around half of the participants. However, most of participants had not taken the vaccine at the time of the study, and the trust in vaccines is not high. Effective interventions by the health authorities are needed to address these issues in order to accelerate the COVID-19 vaccination program in Sudan.", "doi": "10.3934/publichealth.2023023", "pmid": "37304594", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10251048"}, {"db": "pii", "key": "publichealth-10-02-023"}], "notes": [], "created": "2023-10-04T09:31:41.409Z", "modified": "2023-10-04T10:52:10.669Z"}, {"entity": "publication", "iuid": "9a57591bcba24b9093ebed26803aed22", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9a57591bcba24b9093ebed26803aed22.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9a57591bcba24b9093ebed26803aed22"}}, "title": "Companion restrictions in the emergency department during COVID-19: physician perceptions from the Western Cape, South Africa.", "authors": [{"family": "Wiebe", "given": "Lauren E", "initials": "LE", "orcid": "0000-0003-3363-9735", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6559dcbb0024449e97fb89574e910f41.json"}}, {"family": "Alvesson", "given": "Helle Molsted", "initials": "HM"}, {"family": "Stassen", "given": "Willem", "initials": "W", "orcid": "0000-0002-1486-4446", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c751063bf7cf45dc887049c9554e2555.json"}}], "type": "journal article", "published": "2023-05-05", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "5", "pages": "e070982"}, "abstract": "To determine emergency department (ED) physicians' perceptions regarding hospital companions being prohibited from accompanying the patient during COVID-19.\r\n\r\nTwo qualitative datasets were combined. Data collected included voice recordings, narrative interviewing and semistructured interviews. A reflexive thematic analysis was conducted and guided by the Normalisation Process Theory.\r\n\r\nSix hospital EDs in the Western Cape, South Africa.\r\n\r\nConvenience sampling was used to recruit a total of eight physicians working full time in the ED during COVID-19.\r\n\r\nThe lack of physical companions provided an opportunity for physicians to assess and reflect on a companion's role in efficient patient care. Physicians perceived that the COVID-19 restrictions illuminated that patient companions engaged in the ED as providers contributing to patient care by providing collateral information and patient support, while simultaneously engaging as consumers detracting physicians from their priorities and patient care. These restrictions prompted the physicians to consider how they understand their patients largely through the companions. When companions became virtual, the physicians were forced to shift how they perceive their patient, which included increased empathy.\r\n\r\nThe reflections of providers can feed into discussions about values within the healthcare system and can help explore the balance between medical and social safety, especially with companion restrictions still being practised in some hospitals. These perceptions illuminate various tradeoffs physicians had to consider throughout the pandemic and may be used to improve companion policies when planning for the continuation of the COVID-19 pandemic and future disease outbreaks.", "doi": "10.1136/bmjopen-2022-070982", "pmid": "37147101", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10163331"}, {"db": "pii", "key": "bmjopen-2022-070982"}], "notes": [], "created": "2023-10-04T05:10:34.020Z", "modified": "2023-10-04T06:45:49.656Z"}, {"entity": "publication", "iuid": "d9fdabb601214d838e8296641d250b76", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d9fdabb601214d838e8296641d250b76.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d9fdabb601214d838e8296641d250b76"}}, "title": "COVID vaccine evaluation of barriers and resources among families of children with diagnosed allergies.", "authors": [{"family": "Gooding", "given": "Gregory D", "initials": "GD"}, {"family": "Protudjer", "given": "Jennifer L", "initials": "JL"}, {"family": "Gabrielli", "given": "Sofianne", "initials": "S"}, {"family": "Mul\u00e9", "given": "Pasquale", "initials": "P"}, {"family": "Shand", "given": "Greg", "initials": "G"}, {"family": "Zhang", "given": "Xun", "initials": "X"}, {"family": "McCusker", "given": "Christine", "initials": "C"}, {"family": "Noya", "given": "Francisco J", "initials": "FJ"}, {"family": "Harvey", "given": "Maria", "initials": "M"}, {"family": "Chalifour", "given": "M\u00e9lodie", "initials": "M"}, {"family": "Sicard", "given": "Catherine", "initials": "C"}, {"family": "Abrams", "given": "Elissa", "initials": "E"}, {"family": "Amiel", "given": "Jacques-Alexandre", "initials": "J"}, {"family": "Ngo", "given": "Thanh-Thao", "initials": "T"}, {"family": "Bonnici", "given": "Andre", "initials": "A"}, {"family": "MacDonald", "given": "Noni", "initials": "N"}, {"family": "Ben-Shoshan", "given": "Moshe", "initials": "M"}], "type": "journal article", "published": "2023-05-05", "journal": {"title": "Front Allergy", "issn": "2673-6101", "issn-l": null, "volume": "4", "issue": null, "pages": "1101247"}, "abstract": "We aimed to determine vaccine hesitancy and the main barriers associated with the 2019 novel coronavirus, SARS-CoV-2 (COVID-19) vaccination among families of children diagnosed with food/drug/environmental allergies.\r\n\r\nBetween May and June 2021, we approached 146 families seen at the outpatient allergy clinic at the Montreal Children's Hospital and a community allergy practice were invited to complete an anonymous online survey on COVID-19 and vaccination attitudes and behaviour. Uni and multivariable logistic regressions were compared to estimate factors associated with vaccine hesitancy.\r\n\r\nAmong all patients, 24.1% reported vaccine hesitancy. The large majority of parents (95.2%) believed that vaccines work. The most common barrier to vaccination was fear of adverse side effects (57.0%). One-third of participants (31.5%) reported that a history of food, venom and drug allergy was a contraindication for COVID-19 vaccination. Fifty-nine (60.8%) participants stated that the dissemination of additional information would increase their willingness to be vaccinated. Most (96.9%) parents reported that their children's vaccinations were up to date. Hesitant families were more likely to be parents of children aged 6-10 years, be of Asian descent, report that mRNA vaccines are riskier than traditional vaccines, and report that the vaccine should not be given if the child has a history of allergic reaction to vaccines.\r\n\r\nVaccine hesitancy exists mainly among certain ethnic groups and families with young children. Allergies to food, venom and drug allergy are commonly perceived as contraindications for COVID-19 vaccination. Knowledge translation activities addressing parental concerns will help increase vaccination rates.", "doi": "10.3389/falgy.2023.1101247", "pmid": "37216150", "labels": {"Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10198258"}], "notes": [], "created": "2023-10-04T05:09:35.901Z", "modified": "2023-10-04T06:02:16.198Z"}, {"entity": "publication", "iuid": "27e3e8c68bd84f3c969c6cd81e935226", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27e3e8c68bd84f3c969c6cd81e935226.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27e3e8c68bd84f3c969c6cd81e935226"}}, "title": "Efficacy of the combination of monoclonal antibodies against the SARS-CoV-2 Beta and Delta variants.", "authors": [{"family": "Boonkrai", "given": "Chatikorn", "initials": "C"}, {"family": "Cotrone", "given": "Thomas S", "initials": "TS"}, {"family": "Chaisuriyong", "given": "Watchadaporn", "initials": "W"}, {"family": "Tantawichien", "given": "Terapong", "initials": "T"}, {"family": "Thisyakorn", "given": "Usa", "initials": "U"}, {"family": "Fernandez", "given": "Stefan", "initials": "S"}, {"family": "Hunsawong", "given": "Taweewun", "initials": "T"}, {"family": "Reed", "given": "Matthew", "initials": "M"}, {"family": "Wongtangprasert", "given": "Tossapon", "initials": "T"}, {"family": "Audomsun", "given": "Thittaya", "initials": "T"}, {"family": "Phakham", "given": "Tanapati", "initials": "T"}, {"family": "Attakitbancha", "given": "Chadaporn", "initials": "C"}, {"family": "Saelao", "given": "Pijitra", "initials": "P"}, {"family": "Focht", "given": "Dorota", "initials": "D"}, {"family": "Kimbung", "given": "Raymond", "initials": "R"}, {"family": "Welin", "given": "Martin", "initials": "M"}, {"family": "Malik", "given": "Aijaz Ahmad", "initials": "AA"}, {"family": "Pisitkun", "given": "Trairak", "initials": "T"}, {"family": "Srisawat", "given": "Nattachai", "initials": "N", "orcid": "0000-0002-8544-8132", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91b220be054242cd8f36efca9f2a70c8.json"}}], "type": "journal article", "published": "2023-05-04", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "5", "pages": "e0284173"}, "abstract": "The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently the biggest healthcare issue worldwide. This study aimed to develop a monoclonal antibody against SARS-CoV-2 from B cells of recovered COVID-19 patients, which might have beneficial therapeutic purposes for COVID-19 patients. We successfully generated human monoclonal antibodies (hmAbs) against the receptor binding domain (RBD) protein of SARS-CoV-2 using developed hybridoma technology. The isolated hmAbs against the RBD protein (wild-type) showed high binding activity and neutralized the interaction between the RBD and the cellular receptor angiotensin-converting enzyme 2 (ACE2) protein. Epitope binning and crystallography results displayed target epitopes of these antibodies in distinct regions beneficial in the mix as a cocktail. The 3D2 binds to conserved epitopes among multi-variants. Pseudovirion-based neutralization results revealed that the antibody cocktail, 1D1 and 3D2, showed high potency in multiple variants of SARS-CoV-2 infection. In vivo studies showed the ability of the antibody cocktail treatment (intraperitoneal (i.p.) administration) to reduce viral load (Beta variant) in blood and various tissues. While the antibody cocktail treatment (intranasal (i.n.) administration) could not significantly reduce the viral load in nasal turbinate and lung tissue, it could reduce the viral load in blood, kidney, and brain tissue. These findings revealed that the efficacy of the antibody cocktail, 1D1 and 3D2, should be further studied in animal models in terms of timing of administration, optimal dose, and efficacy to mitigate inflammation in targeted tissue such as nasal turbinate and lung.", "doi": "10.1371/journal.pone.0284173", "pmid": "37141227", "labels": {"Category: Serology": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10159178"}, {"db": "pii", "key": "PONE-D-22-27378"}], "notes": [], "created": "2023-10-04T05:08:54.527Z", "modified": "2023-10-04T05:32:42.672Z"}, {"entity": "publication", "iuid": "a1b5dafaa42c438e84a08bf58d2bf8fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a1b5dafaa42c438e84a08bf58d2bf8fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a1b5dafaa42c438e84a08bf58d2bf8fa"}}, "title": "Occupational risk of COVID-19 in foreign-born employees in Denmark.", "authors": [{"family": "Bonde", "given": "J P E", "initials": "JPE", "orcid": "0000-0002-8181-3673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e986911aef045ab8b4b289094387930.json"}}, {"family": "Begtrup", "given": "L M", "initials": "LM"}, {"family": "Jensen", "given": "J H", "initials": "JH"}, {"family": "Flachs", "given": "E M", "initials": "EM"}, {"family": "Jakobsson", "given": "K", "initials": "K"}, {"family": "Nielsen", "given": "C", "initials": "C"}, {"family": "Nilsson", "given": "K", "initials": "K"}, {"family": "Rylander", "given": "L", "initials": "L", "orcid": "0000-0001-8288-8207", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8599a02e51843e8b8f484bc30b6addb.json"}}, {"family": "Vilhelmsson", "given": "A", "initials": "A"}, {"family": "Petersen", "given": "K U", "initials": "KU"}, {"family": "T\u00f8ttenborg", "given": "S S", "initials": "SS", "orcid": "0000-0001-7742-4360", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1e0c5d0c8e249478ce31daacec1d318.json"}}], "type": "journal article", "published": "2023-05-03", "journal": {"title": "Occup Med (Lond)", "issn": "1471-8405", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Foreign-born workers in high-income countries experience higher rates of COVID-19 but the causes are only partially known.\r\n\r\nTo examine if the occupational risk of COVID-19 in foreign-born workers deviates from the risk in native-born employees in Denmark.\r\n\r\nWithin a registry-based cohort of all residents employed in Denmark (n = 2 451 542), we identified four-digit DISCO-08 occupations associated with an increased incidence of COVID-19-related hospital admission during 2020-21 (at-risk occupations). The sex-specific prevalence of at-risk employment in foreign born was compared with the prevalence in native born. Moreover, we examined if the country of birth modified the risk of a positive SARS-CoV-2 polymerase chain reaction (PCR) test and COVID-19-related hospital admission in at-risk occupations.\r\n\r\nWorkers born in low-income countries and male workers from Eastern Europe more often worked in at-risk occupations (relative risks between 1.16 [95% confidence interval {CI} 1.14-1.17] and 1.87 [95% CI 1.82-1.90]). Being foreign-born modified the adjusted risk of PCR test positivity (test for interaction P < 0.0001), primarily because of higher risk in at-risk occupations among men born in Eastern European countries (incidence rate ratio [IRR] 2.39 [95% CI 2.09-2.72] versus IRR 1.19 [95% CI 1.14-1.23] in native-born men). For COVID-19-related hospital admission, no overall interaction was seen, and in women, country of birth did not consistently modify the occupational risk.\r\n\r\nWorkplace viral transmission may contribute to an excess risk of COVID-19 in male workers born in Eastern Europe, but most foreign-born employees in at-risk occupations seem not to be at higher occupational risk than native born.", "doi": "10.1093/occmed/kqad044", "pmid": "37133767", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7150760"}], "notes": [], "created": "2023-10-04T05:08:48.484Z", "modified": "2023-10-04T05:23:13.528Z"}, {"entity": "publication", "iuid": "13eb9e68408349a6b1eade757bfb16f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13eb9e68408349a6b1eade757bfb16f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13eb9e68408349a6b1eade757bfb16f9"}}, "title": "Association between SARS-CoV-2 vaccination and healthcare contacts for menstrual disturbance and bleeding in women before and after menopause: nationwide, register based cohort study.", "authors": [{"family": "Ljung", "given": "Rickard", "initials": "R", "orcid": "0000-0002-0654-4530", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ba40c2b98b1442192811ba44ffbf967.json"}}, {"family": "Xu", "given": "YiYi", "initials": "Y", "orcid": "0000-0001-9106-0049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06663aac11174e88a79cbb8e2ec4f3c0.json"}}, {"family": "Sundstr\u00f6m", "given": "Anders", "initials": "A", "orcid": "0000-0003-2337-3371", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5acbd5b816884f06807b23bd3e2e6cad.json"}}, {"family": "Leach", "given": "Susannah", "initials": "S", "orcid": "0000-0002-9614-2753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18d00be831d241dca238b3253d1b45f6.json"}}, {"family": "Hallberg", "given": "Ebba", "initials": "E"}, {"family": "Bygdell", "given": "Maria", "initials": "M", "orcid": "0000-0002-0737-8642", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8384a1c06034aff9aae842750462643.json"}}, {"family": "Larsson", "given": "Maria", "initials": "M"}, {"family": "Arthurson", "given": "Veronica", "initials": "V"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}, {"family": "Gedeborg", "given": "Rolf", "initials": "R", "orcid": "0000-0002-8850-7863", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/234ef51ed7854efb8bbadc3ce35bf7d9.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}], "type": "journal article", "published": "2023-05-03", "journal": {"title": "BMJ", "issn": "1756-1833", "issn-l": null, "volume": "381", "issue": null, "pages": "e074778"}, "abstract": "To evaluate the risks of any menstrual disturbance and bleeding following SARS-CoV-2 vaccination in women who are premenopausal or postmenopausal.\r\n\r\nA nationwide, register based cohort study.\r\n\r\nAll inpatient and specialised outpatient care in Sweden from 27 December 2020 to 28 February 2022. A subset covering primary care for 40% of the Swedish female population was also included.\r\n\r\n2 946 448 Swedish women aged 12-74 years were included. Pregnant women, women living in nursing homes, and women with history of any menstruation or bleeding disorders, breast cancer, cancer of female genital organs, or who underwent a hysterectomy between 1 January 2015 and 26 December 2020 were excluded.\r\n\r\nSARS-CoV-2 vaccination, by vaccine product (BNT162b2, mRNA-1273, or ChAdOx1 nCoV-19 (AZD1222)) and dose (unvaccinated and first, second, and third dose) over two time windows (one to seven days, considered the control period, and 8-90 days).\r\n\r\nHealthcare contact (admission to hospital or visit) for menstrual disturbance or bleeding before or after menopause (diagnosed with the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision codes N91, N92, N93, N95).\r\n\r\n2 580 007 (87.6%) of 2 946 448 women received at least one SARS-CoV-2 vaccination and 1 652 472 (64.0%) 2 580 007 of vaccinated women received three doses before the end of follow-up. The highest risks for bleeding in women who were postmenopausal were observed after the third dose, in the one to seven days risk window (hazard ratio 1.28 (95% confidence interval 1.01 to 1.62)) and in the 8-90 days risk window (1.25 (1.04 to 1.50)). The impact of adjustment for covariates was modest. Risk of postmenopausal bleeding suggested a 23-33% increased risk after 8-90 days with BNT162b2 and mRNA-1273 after the third dose, but the association with ChAdOx1 nCoV-19 was less clear. For menstrual disturbance or bleeding in women who were premenopausal, adjustment for covariates almost completely removed the weak associations noted in the crude analyses.\r\n\r\nWeak and inconsistent associations were observed between SARS-CoV-2 vaccination and healthcare contacts for bleeding in women who are postmenopausal, and even less evidence was recorded of an association for menstrual disturbance or bleeding in women who were premenopausal. These findings do not provide substantial support for a causal association between SARS-CoV-2 vaccination and healthcare contacts related to menstrual or bleeding disorders.", "doi": "10.1136/bmj-2023-074778", "pmid": "37137493", "labels": {"Category: Health": null, "Funder: VR": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10543813"}], "notes": [], "created": "2023-10-04T05:11:41.147Z", "modified": "2023-10-04T07:18:52.921Z"}, {"entity": "publication", "iuid": "5133ce1ea10e46caae5b032df6ab2b09", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5133ce1ea10e46caae5b032df6ab2b09.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5133ce1ea10e46caae5b032df6ab2b09"}}, "title": "Sociodemographic Factors and Adjustment of Daily Activities During the COVID-19 Pandemic - Findings from the SHARE Corona Survey.", "authors": [{"family": "Olofsson", "given": "Jenny", "initials": "J", "orcid": "0000-0003-0725-951X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed1a80c621ef48b18f45766cc29ce54c.json"}}, {"family": "Fors Connolly", "given": "Filip", "initials": "F", "orcid": "0000-0002-3857-4398", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2fbe2c1c98804f25a5e6c6fdde21fe03.json"}}, {"family": "Malmberg", "given": "Gunnar", "initials": "G", "orcid": "0000-0003-0531-2743", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/efd0e5c960f04373a96ea862b4072b9d.json"}}, {"family": "Josefsson", "given": "Maria", "initials": "M", "orcid": "0000-0002-1812-3581", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b119b08d9787455894f5ee784f0805e5.json"}}, {"family": "Stattin", "given": "Mikael", "initials": "M", "orcid": "0000-0003-0817-0576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9679f7d8f5c8410d83103fcf7d88fe8e.json"}}], "type": "journal article", "published": "2023-05-01", "journal": {"title": "J Aging Soc Policy", "issn": "1545-0821", "issn-l": null, "volume": null, "issue": null, "pages": "1-23"}, "abstract": "In the wake of the COVID-19 pandemic in 2020, older people across Europe have adjusted their daily activities as personal risk avoidance and as an amendment to policy recommendations and restrictions. In this study, we use multilevel logistic regressions to examine to what extent sociodemographic factors are associated with activity reduction among the older population (50+) in Europe and whether these associations are moderated by governmental policy responses to COVID-19. By combining data for~35,000 respondents from the SHARE Corona Survey on reported changes in daily activities and stringency of restrictions at the national level, we find that older age, poorer health and being female versus male were (consistently) associated with greater activity reduction across all activities both in countries with weak and in those with strong restrictions. Associations between education, employment and living situation, on the one hand, and activity reduction, on the other, were weaker and less consistent. We conclude that differences between sociodemographic groups are rather similar for countries with weak and those with strong restrictions and hence argue that group-specific policy recommendation are relevant independent of stringency recommendations.", "doi": "10.1080/08959420.2023.2206077", "pmid": "37125862", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:10:47.974Z", "modified": "2023-10-04T06:58:45.924Z"}, {"entity": "publication", "iuid": "7fdb5107e7e6410682607672a304c086", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7fdb5107e7e6410682607672a304c086.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7fdb5107e7e6410682607672a304c086"}}, "title": "Transition from physical to online shopping alternatives due to the COVID-19 pandemic - A case study of Italy and Sweden.", "authors": [{"family": "Andruetto", "given": "Claudia", "initials": "C"}, {"family": "Bin", "given": "Elisa", "initials": "E"}, {"family": "Susilo", "given": "Yusak", "initials": "Y"}, {"family": "Pernest\u00e5l", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "Transp Res Part A Policy Pract", "issn": "0965-8564", "volume": "171", "pages": "103644", "issn-l": null}, "abstract": "Using 530 responses from an online questionnaire, this study aims to investigate the transition from physical to online shopping alternatives during the first wave of the COVID-19 pandemic at the individual level. The focus areas of the study are Sweden and Italy, two European countries that implemented contrasting prevention measures. This study analyses the impacts of the pandemic on the transition to online shopping activities, and identifies who among the respondents changed their shopping behaviour the most and how; and what the different shopping strategies are and who adopted them. Multivariate statistical analyses, including linear and binary logistic regressions and multinomial logit models, were used to analyse the dataset. In the analysis, the dataset was split between Italy and Sweden to take into account the contrasting prevention measures and the different social and economic backgrounds of the two countries; the results of this study confirm and highlight these differences. Moreover, the socio-demographic and household structures of the respondents were found to influence the amount and the direction of change in shopping behaviour during the first wave of the pandemic. The study also indicates some policies that can be implemented and/or further strengthened to increase the resilience of citizens in facing pandemics and to derive benefit from the behavioural changes that took place during the first wave of the pandemic.", "doi": "10.1016/j.tra.2023.103644", "pmid": "36960356", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10008802"}, {"db": "pii", "key": "S0965-8564(23)00064-2"}], "notes": [], "created": "2023-04-21T16:04:23.892Z", "modified": "2023-04-21T16:04:23.911Z"}, {"entity": "publication", "iuid": "6a85486d50604effabbb6b75db7a7082", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a85486d50604effabbb6b75db7a7082.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a85486d50604effabbb6b75db7a7082"}}, "title": "Segregation and the pandemic: The dynamics of daytime social diversity during COVID-19 in Greater Stockholm.", "authors": [{"family": "M\u00fc\u00fcrisepp", "given": "Kerli", "initials": "K"}, {"family": "J\u00e4rv", "given": "Olle", "initials": "O"}, {"family": "Sj\u00f6blom", "given": "Feliks", "initials": "F"}, {"family": "Toger", "given": "Marina", "initials": "M"}, {"family": "\u00d6sth", "given": "John", "initials": "J"}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "Appl Geogr", "issn": "0143-6228", "volume": "154", "pages": "102926", "issn-l": null}, "abstract": "In this study, we set out to understand how the changes in daily mobility of people during the first wave of the COVID-19 pandemic in spring 2020 influenced daytime spatial segregation. Rather than focusing on spatial separation, we approached this task from the perspective of daytime socio-spatial diversity - the degree to which people from socially different neighbourhoods share urban space during the day. By applying mobile phone data from Greater Stockholm, Sweden, the study examines weekly changes in 1) daytime social diversity across different types of neighbourhoods, and 2) population groups' exposure to diversity in their main daytime activity locations. Our findings show a decline in daytime diversity in neighbourhoods when the pandemic broke out in mid-March 2020. The decrease in diversity was marked in urban centres, and significantly different in neighbourhoods with different socio-economic and ethnic compositions. Moreover, the decrease in people's exposure to diversity in their daytime activity locations was even more profound and long-lasting. In particular, isolation from diversity increased more among residents of high-income majority neighbourhoods than of low-income minority neighbourhoods. We conclude that while some COVID-19-induced changes might have been temporary, the increased flexibility in where people work and live might ultimately reinforce both residential and daytime segregation.", "doi": "10.1016/j.apgeog.2023.102926", "pmid": "36999002", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC9998301"}, {"db": "pii", "key": "S0143-6228(23)00057-7"}], "notes": [], "created": "2023-04-21T15:50:37.167Z", "modified": "2023-04-21T15:50:59.427Z"}, {"entity": "publication", "iuid": "ca29acd5924d4774918cb18f04a947aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ca29acd5924d4774918cb18f04a947aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ca29acd5924d4774918cb18f04a947aa"}}, "title": "Pre- and post-vaccination characteristics and risk factors for COVID-19 outcomes in a Swedish population-based cohort of COPD patients.", "authors": [{"family": "Kirui", "given": "Brian K", "initials": "BK"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW", "orcid": "0000-0002-4387-4096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bb5d1f761ef48c4837ed4f984717f0e.json"}}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Franz\u00e9n", "given": "Stefan", "initials": "S", "orcid": "0000-0001-6622-3838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e2fc66fb68748eba5a7f8eb93c5ff3f.json"}}, {"family": "Stridsman", "given": "Caroline", "initials": "C", "orcid": "0000-0001-6622-3838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e2fc66fb68748eba5a7f8eb93c5ff3f.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "ERJ Open Res", "issn": "2312-0541", "issn-l": null, "volume": "9", "issue": "3", "pages": null}, "abstract": "Evidence on risk factors for Coronavirus disease 2019 (COVID-19) outcomes among patients with COPD in relation to COVID-19 vaccination remains limited. The objectives of the present study were to characterise determinants of COVID-19 infection, hospitalisation, intensive care unit (ICU) admission and death in COPD patients in their unvaccinated state compared to when vaccinated.\r\n\r\nWe included all COPD patients in the Swedish National Airway Register (SNAR). Events of COVID-19 infection (test and/or healthcare encounter), hospitalisation, ICU admission and death were identified from 1 January 2020 to 30 November 2021. Using adjusted Cox regression, associations between baseline sociodemographics, comorbidities, treatments, clinical measurements and COVID-19 outcomes, during unvaccinated and vaccinated follow-up time, were analysed.\r\n\r\nThe population-based COPD cohort included 87 472 patients, among whom 6771 (7.7%) COVID-19 infections, 2897 (3.3%) hospitalisations, 233 (0.3%) ICU admissions and 882 (1.0%) COVID-19 deaths occurred. During unvaccinated follow-up, risk of COVID-19 hospitalisation and death increased with age, male sex, lower education, non-married status and being foreign-born. Comorbidities increased risk of several outcomes, e.g. respiratory failure for infection and hospitalisation (adjusted hazard ratios (HR) 1.78, 95% CI 1.58-2.02 and 2.51, 2.16-2.91, respectively), obesity for ICU admission (3.52, 2.29-5.40) and cardiovascular disease for mortality (2.80, 2.16-3.64). Inhaled COPD therapy was associated with infection, hospitalisation and death. COPD severity was also associated with COVID-19, especially hospitalisation and death. Although the risk factor panorama was similar, COVID-19 vaccination attenuated HRs for some risk factors.\r\n\r\nThis study provides population-based evidence on predictive risk factors for COVID-19 outcomes and highlights the positive implications of COVID-19 vaccination for COPD patients.", "doi": "10.1183/23120541.00711-2022", "pmid": "37377661", "labels": {"Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10291311"}, {"db": "pii", "key": "00711-2022"}], "notes": [], "created": "2023-10-04T09:30:36.503Z", "modified": "2023-10-04T09:59:26.297Z"}, {"entity": "publication", "iuid": "757f413ea2304a4aac07ae5416a34990", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/757f413ea2304a4aac07ae5416a34990.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/757f413ea2304a4aac07ae5416a34990"}}, "title": "Microneedle Patch for Painless Intradermal Collection of Interstitial Fluid Enabling Multianalyte Measurement of Small Molecules, SARS-CoV-2 Antibodies, and Protein Profiling.", "authors": [{"family": "Ribet", "given": "Federico", "initials": "F", "orcid": "0000-0002-3549-0228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70e482c3c2454cb0924540e41bd5eb72.json"}}, {"family": "Bendes", "given": "Annika", "initials": "A"}, {"family": "Fredolini", "given": "Claudia", "initials": "C"}, {"family": "Dobielewski", "given": "Mikolaj", "initials": "M"}, {"family": "B\u00f6ttcher", "given": "Michael", "initials": "M"}, {"family": "Beck", "given": "Olof", "initials": "O"}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM"}, {"family": "Stemme", "given": "G\u00f6ran", "initials": "G"}, {"family": "Roxhed", "given": "Niclas", "initials": "N"}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "Adv Healthc Mater", "issn": "2192-2659", "issn-l": null, "volume": "12", "issue": "13", "pages": "e2202564"}, "abstract": "Blood sampling is a common practice to monitor health, but it entails a series of drawbacks for patients including pain and discomfort. Thus, there is a demand for more convenient ways to obtain samples. Modern analytical techniques enable monitoring of multiple bioanalytes in smaller samples, opening possibilities for new matrices, and microsampling technologies to be adopted. Interstitial fluid (ISF) is an attractive alternative matrix that shows good correlation with plasma concentration dynamics for several analytes and can be sampled in a minimally invasive and painless manner from the skin at the point-of-care. However, there is currently a lack of sampling devices compatible with clinical translation. Here, to tackle state-of-the-art limitations, a cost-effective and compact single-microneedle-based device designed to painlessly collect precisely 1.1 \u00b5L of dermal ISF within minutes is presented. The fluid is volume-metered, dried, and stably stored into analytical-grade paper within the microfluidic device. The obtained sample can be mailed to a laboratory, quantitatively analyzed, and provide molecular insights comparable to blood testing. In a human study, the possibility to monitor various classes of molecular analytes is demonstrated in ISF microsamples, including caffeine, hundreds of proteins, and SARS-CoV-2 antibodies, some being detected in ISF for the first time.", "doi": "10.1002/adhm.202202564", "pmid": "36748807", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Funder: H2020": null}, "xrefs": [{"db": "URL", "key": "https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fadhm.202202564&file=adhm202202564-sup-0001-SuppMat.pdf", "description": "https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fadhm.202202564&file=adhm202202564-sup-0001-SuppMat.pdf"}], "notes": [], "created": "2023-02-13T17:56:35.394Z", "modified": "2023-06-19T14:19:26.937Z"}, {"entity": "publication", "iuid": "97df576b98e6430cbe84455e52197b3a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/97df576b98e6430cbe84455e52197b3a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/97df576b98e6430cbe84455e52197b3a"}}, "title": "Insight into vaccination and meteorological factors on daily COVID-19 cases and mortality in Bangladesh.", "authors": [{"family": "Hasan", "given": "Mohammad Nayeem", "initials": "MN"}, {"family": "Islam", "given": "Md Aminul", "initials": "MA"}, {"family": "Sangkham", "given": "Sarawut", "initials": "S"}, {"family": "Werkneh", "given": "Adhena Ayaliew", "initials": "AA"}, {"family": "Hossen", "given": "Foysal", "initials": "F"}, {"family": "Haque", "given": "Md Atiqul", "initials": "MA"}, {"family": "Alam", "given": "Mohammad Morshad", "initials": "MM"}, {"family": "Rahman", "given": "Md Arifur", "initials": "MA"}, {"family": "Mukharjee", "given": "Sanjoy Kumar", "initials": "SK"}, {"family": "Chowdhury", "given": "Tahmid Anam", "initials": "TA"}, {"family": "Sosa-Hern\u00e1ndez", "given": "Juan Eduardo", "initials": "JE"}, {"family": "Jakariya", "given": "Md", "initials": "M"}, {"family": "Ahmed", "given": "Firoz", "initials": "F"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Sarkodie", "given": "Samuel Asumadu", "initials": "SA"}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "Groundw Sustain Dev", "issn": "2352-801X", "volume": "21", "pages": "100932", "issn-l": null}, "abstract": "The ongoing COVID-19 contagious disease caused by SARS-CoV-2 has disrupted global public health, businesses, and economies due to widespread infection, with 676.41 million confirmed cases and 6.77 million deaths in 231 countries as of February 07, 2023. To control the rapid spread of SARS-CoV-2, it is crucial to determine the potential determinants such as meteorological factors and their roles. This study examines how COVID-19 cases and deaths changed over time while assessing meteorological characteristics that could impact these disparities from the onset of the pandemic. We used data spanning two years across all eight administrative divisions, this is the first of its kind--showing a connection between meteorological conditions, vaccination, and COVID-19 incidences in Bangladesh. We further employed several techniques including Simple Exponential Smoothing (SES), Auto-Regressive Integrated Moving Average (ARIMA), Auto-Regressive Integrated Moving Average with explanatory variables (ARIMAX), and Automatic forecasting time-series model (Prophet). We further analyzed the effects of COVID-19 vaccination on daily cases and deaths. Data on COVID-19 cases collected include eight administrative divisions of Bangladesh spanning March 8, 2020, to January 31, 2023, from available online servers. The meteorological data include rainfall (mm), relative humidity (%), average temperature (\u00b0C), surface pressure (kPa), dew point (\u00b0C), and maximum wind speed (m/s). The observed wind speed and surface pressure show a significant negative impact on COVID-19 cases (-0.89, 95% confidence interval (CI): 1.62 to -0.21) and (-1.31, 95%CI: 2.32 to -0.29), respectively. Similarly, the observed wind speed and surface pressure show a significant negative impact on COVID-19 deaths (-0.87, 95% CI: 1.54 to -0.21) and (-3.11, 95%CI: 4.44 to -1.25), respectively. The impact of meteorological factors is almost similar when vaccination information is included in the model. However, the impact of vaccination in both cases and deaths model is significantly negative (for cases: 1.19, 95%CI: 2.35 to -0.38 and for deaths: 1.55, 95%CI: 2.88 to -0.43). Accordingly, vaccination effectively reduces the number of new COVID-19 cases and fatalities in Bangladesh. Thus, these results could assist future researchers and policymakers in the assessment of pandemics, by making thorough efforts that account for COVID-19 vaccinations and meteorological conditions.", "doi": "10.1016/j.gsd.2023.100932", "pmid": "36945723", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9977696"}, {"db": "pii", "key": "S2352-801X(23)00032-2"}], "notes": [], "created": "2023-04-21T16:07:26.169Z", "modified": "2023-04-21T16:07:26.184Z"}, {"entity": "publication", "iuid": "18e6b93c9ab24c4f91ca0341366a0aae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18e6b93c9ab24c4f91ca0341366a0aae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18e6b93c9ab24c4f91ca0341366a0aae"}}, "title": "Ambient air pollution exposure linked to long COVID among young adults: a nested survey in a population-based cohort in Sweden.", "authors": [{"family": "Yu", "given": "Zhebin", "initials": "Z"}, {"family": "Ekstr\u00f6m", "given": "Sandra", "initials": "S"}, {"family": "Bellander", "given": "Tom", "initials": "T"}, {"family": "Ljungman", "given": "Petter", "initials": "P"}, {"family": "Pershagen", "given": "G\u00f6ran", "initials": "G"}, {"family": "Eneroth", "given": "Kristina", "initials": "K"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "Bergstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Georgelis", "given": "Antonios", "initials": "A"}, {"family": "Stafoggia", "given": "Massimo", "initials": "M"}, {"family": "Gruzieva", "given": "Olena", "initials": "O"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "BAMSE COVID-19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "issn-l": null, "volume": "28", "issue": null, "pages": "100608"}, "abstract": "Post COVID-19 conditions, also known as long COVID, are of public health concern, but little is known about their underlying risk factors. We aimed to investigate associations of air pollution exposure with long COVID among Swedish young adults.\r\n\r\nWe used data from the BAMSE (Children, Allergy, Environment, Stockholm, Epidemiology [in Swedish]) cohort. From October 2021 to February 2022 participants answered a web-questionnaire focusing on persistent symptoms following acute SARS-CoV-2 infection. Long COVID was defined as symptoms after confirmed infection with SARS-CoV-2 lasting for two months or longer. Ambient air pollution levels (particulate matter \u22642.5 \u03bcm [PM2.5], \u226410 \u03bcm [PM10], black carbon [BC] and nitrogen oxides [NOx]) at individual-level addresses were estimated using dispersion modelling.\r\n\r\nA total of 753 participants with SARS-CoV-2 infection were included of whom 116 (15.4%) reported having long COVID. The most common symptoms were altered smell/taste (n = 80, 10.6%), dyspnea (n = 36, 4.8%) and fatigue (n = 34, 4.5%). Median annual PM2.5 exposure in 2019 (pre-pandemic) was 6.39 (interquartile range [IQR] 6.06-6.71) \u03bcg/m3. Adjusted Odds Ratios (95% confidence intervals) of PM2.5 per IQR increase were 1.28 (1.02-1.60) for long COVID, 1.65 (1.09-2.50) for dyspnea symptoms and 1.29 (0.97-1.70) for altered smell/taste. Positive associations were found for the other air pollutants and remained consistent across sensitivity analyses. Associations tended to be stronger among participants with asthma, and those having had COVID during 2020 (versus 2021).\r\n\r\nAmbient long-term PM2.5 exposure may affect the risk of long COVID in young adults, supporting efforts for continuously improving air quality.\r\n\r\nThe study received funding from the Swedish Research Council (grant no. 2020-01886, 2022-06340), the Swedish Research Council for Health, Working life and Welfare (FORTE grant no. 2017-01146), the Swedish Heart-Lung Foundation, Karolinska Institute (no. 2022-01807) and Region Stockholm (ALF project for cohort and database maintenance).", "doi": "10.1016/j.lanepe.2023.100608", "pmid": "37131862", "labels": {"Category: Post-COVID": null, "Funder: VR": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9989696"}, {"db": "pii", "key": "S2666-7762(23)00026-1"}], "notes": [], "created": "2023-10-04T05:10:14.692Z", "modified": "2023-10-04T06:31:11.088Z"}, {"entity": "publication", "iuid": "e2c251d61bc24c6ba1f59716f2af86f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2c251d61bc24c6ba1f59716f2af86f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2c251d61bc24c6ba1f59716f2af86f8"}}, "title": "Lessons learnt during COVID-19: making sense of Australian and Swedish university lecturers' experience.", "authors": [{"family": "Turner", "given": "Kristina", "initials": "K", "orcid": "0000-0002-0585-9207", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43081e9e652c4bd7a7a06d3289a5968c.json"}}, {"family": "O'Brien", "given": "Siobhan", "initials": "S"}, {"family": "Wallstr\u00f6m", "given": "Helena", "initials": "H"}, {"family": "Samuelsson", "given": "Katarina", "initials": "K"}, {"family": "Uusim\u00e4ki", "given": "Sirkka-Liisa Marjatta", "initials": "SM"}], "type": "journal article", "published": "2023-04-28", "journal": {"title": "Int J Educ Technol High Educ", "issn": "2365-9440", "issn-l": null, "volume": "20", "issue": "1", "pages": "25"}, "abstract": "This article reports on a study analysing changes in the use of digital technologies and working from home during the COVID-19 crisis and the impact of these changes on the wellbeing of five female university lecturers from Australia and Sweden. Applying collaborative autoethnographical methods, this study employed Weick's sensemaking framework to explore how the academics made sense of these sudden changes. The Positive emotion, Engagement, Relationships, Meaning, and Accomplishment (PERMA) wellbeing framework was also employed to explore the effect of these changes on the academics' wellbeing. Findings from the reflective narratives show that after the initial experiences of stress, each university lecturer was able to adapt and navigate the online teaching environment during the pandemic. However, the time constraints in preparing and adapting to online teaching, and working from home, were experienced by some of the university lecturers as highly stressful and isolating which impacted their sense of wellbeing. Even so, working from home was recognized as a positive experience, providing time for research, hobbies, and time with family. This study addresses a gap in current knowledge by examining the impact of the sudden transition to online teaching and learning had on academic wellbeing as conceptualised through the PERMA framework. In addition, by applying Weick's sensemaking framework, this study provides a unique perspective around how academics made sense of the sudden switch to online teaching and learning during COVID-19.", "doi": "10.1186/s41239-023-00395-5", "pmid": "37131502", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10139830"}, {"db": "pii", "key": "395"}], "notes": [], "created": "2023-10-04T05:11:08.068Z", "modified": "2023-10-04T07:07:32.243Z"}, {"entity": "publication", "iuid": "f85426a33bd547b5b2d964cd3f37287a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f85426a33bd547b5b2d964cd3f37287a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f85426a33bd547b5b2d964cd3f37287a"}}, "title": "Physical functioning post-COVID-19 and the recovery process: a mixed methods study.", "authors": [{"family": "Tofiq", "given": "Avin", "initials": "A", "orcid": "0000-0003-1712-7510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1460dc1501cf4a599430688991f6139f.json"}}, {"family": "Eriksson Crommert", "given": "Martin", "initials": "M"}, {"family": "Zakrisson", "given": "Ann-Britt", "initials": "AB", "orcid": "0000-0002-8370-8834", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc03287b22de4d27bb5d594b7e4ac7f3.json"}}, {"family": "von Euler", "given": "Mia", "initials": "M"}, {"family": "Nilsing Strid", "given": "Emma", "initials": "E", "orcid": "0000-0002-0483-8981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6022f01a844440ea4ca64f114b47058.json"}}], "type": "journal article", "published": "2023-04-20", "journal": {"title": "Disabil Rehabil", "issn": "1464-5165", "pages": "1-10", "issn-l": null}, "abstract": "To describe physical functioning after severe COVID-19-infection.\n\nAn explanatory sequential mixed method design was used. Thirty-nine participants performed tests and answered questionnaires measuring physical functioning six months after hospitalisation due to COVID-19. Thirty of these participants participated in semi-structured interviews with questions regarding how they perceived their physical functioning and recovery from COVID-19 at 12 months post-hospitalisation.\n\nAt six months, physical functioning measured via chair stand test and hip-worn accelerometers was lower than normal reference values. There was a reduction in breathing muscle strength. Participants estimated their functional status during different activities as lower compared to those before COVID-19-infection, measured with a patient-specific functional scale. At one year after infection, there were descriptions of a rough recovery process and remaining symptoms.\n\nPatients recovering from severe COVID-19 seem to have reduced physical functioning and activity levels, and they perceive their recovery to be slow and difficult. They experienced a lack of clinical support and contradictory advice regarding rehabilitation. Coaching in returning to physical functioning after the infection needs to be better co-ordinated and there is a need for guidelines for health professionals to avoid patients receiving contradictory advice.", "doi": "10.1080/09638288.2023.2201512", "pmid": "37078388", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [], "notes": [], "created": "2023-04-20T17:18:25.671Z", "modified": "2023-04-20T17:18:25.834Z"}, {"entity": "publication", "iuid": "355f4f39a9d045f09a4a8f7b1b5a5114", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/355f4f39a9d045f09a4a8f7b1b5a5114.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/355f4f39a9d045f09a4a8f7b1b5a5114"}}, "title": "Impairment of quality of life due to COVID-19-induced long-term olfactory dysfunction.", "authors": [{"family": "Winter", "given": "Anja L", "initials": "AL"}, {"family": "Henecke", "given": "Sofie", "initials": "S"}, {"family": "Lundstr\u00f6m", "given": "Johan N", "initials": "JN"}, {"family": "Thunell", "given": "Evelina", "initials": "E"}], "type": "journal article", "published": "2023-04-20", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "14", "issue": null, "pages": "1165911"}, "abstract": "Olfactory dysfunction is one of many long-lasting symptoms associated with COVID-19, estimated to affect approximately 60% of individuals and often lasting several months after infection. The associated daily life problems can cause a decreased quality of life.\r\n\r\nHere, we assessed the association between perceived quality of life and both qualitative and quantitative olfactory function (distorted and weakened sense of smell, respectively) in 58 individuals who had undergone confirmed SARS-CoV-2 infection and who complained about olfactory dysfunction.\r\n\r\nParticipants with large quantitative olfactory dysfunction experienced a greater reduction in their quality of life. Moreover, our participants had a high prevalence of qualitative olfactory dysfunction (81%) with a significant correlation between qualitative olfactory dysfunction and daily life impairment. Strong drivers of low quality of life assessments were lack of enjoyment of food as well as worries related to coping with long-term dysfunctions.\r\n\r\nThese results stress the clinical importance of assessing qualitative olfactory dysfunction and the need to develop relevant interventions. Given the poor self-rated quality of life observed, healthcare systems should consider developing support structures, dietary advice, and guidelines adapted to individuals experiencing qualitative olfactory dysfunction.", "doi": "10.3389/fpsyg.2023.1165911", "pmid": "37151341", "labels": {"Category: Post-COVID": null, "Funder: VR": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC10157159"}], "notes": [], "created": "2023-10-04T05:10:26.106Z", "modified": "2023-10-04T06:38:09.971Z"}, {"entity": "publication", "iuid": "a238c04e9e0549458fbbb0ef9cb9d776", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a238c04e9e0549458fbbb0ef9cb9d776.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a238c04e9e0549458fbbb0ef9cb9d776"}}, "title": "Self-care behaviours of patients with left ventricular assist devices in Israel: changes during the COVID-19 pandemic.", "authors": [{"family": "Melnikov", "given": "Semyon", "initials": "S"}, {"family": "Ben Avraham", "given": "Binyamin", "initials": "B"}, {"family": "Itzhaki Ben Zadok", "given": "Osnat", "initials": "O"}, {"family": "Shaul", "given": "Aviv", "initials": "A"}, {"family": "Abuhazira", "given": "Miri", "initials": "M"}, {"family": "Yaari", "given": "Vicky", "initials": "V"}, {"family": "Jaarsma", "given": "Tiny", "initials": "T"}, {"family": "Ben-Gal", "given": "Tuvia", "initials": "T"}], "type": "journal article", "published": "2023-04-19", "journal": {"title": "ESC Heart Fail", "issn": "2055-5822", "issn-l": null}, "abstract": "Left ventricular assist devices (LVADs) support the hearts of patients with advanced heart failure. Following LVAD implantation, patients face a complex regimen of self-care behaviours including self-care maintenance, self-care monitoring and self-care management. However, during the COVID-19 pandemic, symptoms of anxiety and depression may have interfered with their self-care. Currently, little is known on how specific self-care behaviours of LVAD-implanted patients changed during the COVID-19 pandemic. We aim to describe the changes in self-care behaviours among patients with an implanted LVAD in Israel during the COVID-19 pandemic and explore the factors related to self-care behaviour change.\n\nA prospective observational cross-sectional study design. A convenience sample of 27 Israeli LVAD-implanted patients (mean age 62.4 \u00b1 9, 86% male, 78.6% living with a partner) completed the LVAD Self-Care Behaviour Scale (1 = never to 5 = always) and Hospital Anxiety and Depression Scale (0 = not at all to 3 = most of the time). Data were collected before and after the onset of the COVID-19 pandemic in Israel. Statistical analyses included paired t-tests, Pearson's correlations, and one-way repeated measures ANOVAs.\n\nDuring the COVID-19 pandemic, a significant decrease was found in patients' adherence to checking and recording their LVAD speed, flow, power and PI (Pulsatility Index) (P = 0.05), checking their INR (P = 0.01), and daily weighing (P < 0.01). The prevalence of some behaviours (e.g. regularly exercising) increased in some patients and decreased in others. Patients living without a partner worsened their adherence to some of the self-care behaviours (e.g. taking medicines as prescribed), compared with those living with a partner (Mb = 5.0 \u00b1 0 and Md = 5.0 \u00b1 0, delta = 0 vs. Mb = 5.0 \u00b1 0 and Md = 4.6 \u00b1 0.9, delta = -0.4, respectively; F = 4.9, P = 0.04). Women, and not men, tended to improve their adherence to the self-care behaviour such as avoiding kinking, pulling, or moving the LVAD driveline at the exit site (Mb = 4.0 \u00b1 1.0 and Md = 5.0 \u00b1 0, delta = 1.0 vs. Mb = 4.5 \u00b1 0.9 and Md = 4.4 \u00b1 1.2, delta = -0.1, F = 4.7, P = 0.04, respectively). In total, 41% (11) patients reported neither anxiety nor depression, 11% (3) reported anxiety, 15% (4) reported depression, and 44% (12) reported both anxiety and depression. No associations between anxiety and/or depression and self-care behaviours were found.\n\nPriorities in self-care behaviours among patients with implanted LVAD changed after the onset of the COVID-19 pandemic. Factors that assisted with adherence to self-care behaviours included living with a partner and being female. The current results may guide further research on identifying behaviours that are at risk of not being maintained during a time of emergency.", "doi": "10.1002/ehf2.14376", "pmid": "37075748", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-20T17:20:14.850Z", "modified": "2023-04-20T17:20:14.854Z"}, {"entity": "publication", "iuid": "8a5bbed2693e49ad9287f37d8e9ffe0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a5bbed2693e49ad9287f37d8e9ffe0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a5bbed2693e49ad9287f37d8e9ffe0e"}}, "title": "The role of booster vaccination in decreasing COVID-19 age-adjusted case fatality rate: Evidence from 32 countries.", "authors": [{"family": "Zhou", "given": "Cui", "initials": "C"}, {"family": "Wheelock", "given": "\u00c5sa M", "initials": "\u00c5M"}, {"family": "Zhang", "given": "Chutian", "initials": "C"}, {"family": "Ma", "given": "Jian", "initials": "J"}, {"family": "Dong", "given": "Kaixing", "initials": "K"}, {"family": "Pan", "given": "Jingxiang", "initials": "J"}, {"family": "Li", "given": "Zhichao", "initials": "Z"}, {"family": "Liang", "given": "Wannian", "initials": "W"}, {"family": "Gao", "given": "Jing", "initials": "J"}, {"family": "Xu", "given": "Lei", "initials": "L"}], "type": "journal article", "published": "2023-04-18", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "1150095"}, "abstract": "The global COVID-19 pandemic is still ongoing, and cross-country and cross-period variation in COVID-19 age-adjusted case fatality rates (CFRs) has not been clarified. Here, we aimed to identify the country-specific effects of booster vaccination and other features that may affect heterogeneity in age-adjusted CFRs with a worldwide scope, and to predict the benefit of increasing booster vaccination rate on future CFR.\r\n\r\nCross-temporal and cross-country variations in CFR were identified in 32 countries using the latest available database, with multi-feature (vaccination coverage, demographic characteristics, disease burden, behavioral risks, environmental risks, health services and trust) using Extreme Gradient Boosting (XGBoost) algorithm and SHapley Additive exPlanations (SHAP). After that, country-specific risk features that affect age-adjusted CFRs were identified. The benefit of booster on age-adjusted CFR was simulated by increasing booster vaccination by 1-30% in each country.\r\n\r\nOverall COVID-19 age-adjusted CFRs across 32 countries ranged from 110 deaths per 100,000 cases to 5,112 deaths per 100,000 cases from February 4, 2020 to Jan 31, 2022, which were divided into countries with age-adjusted CFRs higher than the crude CFRs and countries with age-adjusted CFRs lower than the crude CFRs (n = 9 and n = 23) when compared with the crude CFR. The effect of booster vaccination on age-adjusted CFRs becomes more important from Alpha to Omicron period (importance scores: 0.03-0.23). The Omicron period model showed that the key risk factors for countries with higher age-adjusted CFR than crude CFR are low GDP per capita and low booster vaccination rates, while the key risk factors for countries with higher age-adjusted CFR than crude CFR were high dietary risks and low physical activity. Increasing booster vaccination rates by 7% would reduce CFRs in all countries with age-adjusted CFRs higher than the crude CFRs.\r\n\r\nBooster vaccination still plays an important role in reducing age-adjusted CFRs, while there are multidimensional concurrent risk factors and precise joint intervention strategies and preparations based on country-specific risks are also essential.", "doi": "10.3389/fpubh.2023.1150095", "pmid": "37143970", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10151823"}], "notes": [], "created": "2023-10-04T05:12:06.882Z", "modified": "2023-10-04T07:28:47.537Z"}, {"entity": "publication", "iuid": "45834f0045954b6280dea027a997784b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/45834f0045954b6280dea027a997784b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/45834f0045954b6280dea027a997784b"}}, "title": "Plasmablasts in previously immunologically na\u00efve COVID-19 patients express markers indicating mucosal homing and secrete antibodies cross-reacting with SARS-CoV-2 variants and other beta-coronaviruses.", "authors": [{"family": "Lundgren", "given": "Anna", "initials": "A"}, {"family": "Leach", "given": "Susannah", "initials": "S", "orcid": "0000-0002-9614-2753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18d00be831d241dca238b3253d1b45f6.json"}}, {"family": "Axelsson", "given": "Hannes", "initials": "H"}, {"family": "Isakson", "given": "Pauline", "initials": "P"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Scharf", "given": "Lydia", "initials": "L"}, {"family": "Andersson", "given": "Bengt A", "initials": "BA"}, {"family": "Miron", "given": "Nicolae", "initials": "N"}, {"family": "Marklund", "given": "Emelie", "initials": "E"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Gisslen", "given": "Magnus", "initials": "M"}, {"family": "Angeletti", "given": "Davide", "initials": "D"}, {"family": "Bemark", "given": "Mats", "initials": "M", "orcid": "0000-0001-7416-9819", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ae923943b6c4b4bb74ca1e14b426351.json"}}], "type": "journal article", "published": "2023-04-18", "journal": {"title": "Clin Exp Immunol", "issn": "1365-2249", "issn-l": null}, "abstract": "Antigen-specific class-switched antibodies are detected at the same time or even before IgM in serum of non-vaccinated individuals infected with SARS-CoV-2. These derive from the first wave of plasmablasts formed. The phenotype and specificity of plasmablasts can reveal information about early B cell activation. Here we have analyzed B cells and plasmablasts circulating in blood of COVID-19 patients not previously exposed to SARS-CoV-2 during and after disease. We find that during infection with the original Wuhan strain, plasmablasts in blood produce IgA1, IgG1 and IgM, and that most express CCR10 and integrin \u03b21, only some integrin \u03b27, while the majority lack CCR9. Plasmablast-secreted antibodies are reactive to the Spike (S) and Nucleocapsid (N) proteins of the Wuhan strain as well as later variants of concern, but also bind S proteins from endemic and non-circulating betacoronaviruses. In contrast, after recovery, antibodies produced from memory B cells target variants of SARS-CoV-2 and SARS-CoV-1 but compared to previously non-infected individuals do not show increased binding to endemic coronaviruses. This suggests that the early antibody response to a large extent stems from pre-existing cross-reactive class-switched memory B cells, but that that although newly formed memory cells target the novel SARS-CoV-2 virus the numbers of broadly cross-reactive memory B cells do not increase extensively. The observations give insight into the role of pre-existing memory B cells in early antibody responses to novel pathogens and may explain why class-switched antibodies are detected early in serum of COVID-19 patients.", "doi": "10.1093/cei/uxad044", "pmid": "37071584", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "7127793"}], "notes": [], "created": "2023-04-20T17:21:24.291Z", "modified": "2023-04-20T17:21:48.207Z"}, {"entity": "publication", "iuid": "a7144432b32143a1949e61e162ef5874", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7144432b32143a1949e61e162ef5874.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7144432b32143a1949e61e162ef5874"}}, "title": "Contact allergy investigations in healthcare workers with face mask-related skin disease.", "authors": [{"family": "Brynolf", "given": "Andreas", "initials": "A", "orcid": "0009-0008-9710-8048", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e085284ebd94b34892969d3c8b364f0.json"}}, {"family": "Hauksson", "given": "Inese", "initials": "I"}, {"family": "Bergendorff", "given": "Ola", "initials": "O"}, {"family": "Svedman", "given": "Cecilia", "initials": "C", "orcid": "0000-0003-4797-0269", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fda1bd9c72f346e499ff64aef7394a56.json"}}, {"family": "Hamnerius", "given": "Nils", "initials": "N", "orcid": "0000-0001-5188-7711", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee788e8a5610497c9ef14e0860375614.json"}}], "type": "journal article", "published": "2023-04-18", "journal": {"title": "Contact Dermatitis", "issn": "1600-0536", "issn-l": null}, "abstract": "During the COVID-19 pandemic, the use of face masks has increased among healthcare workers (HCWs). Questionnaire studies have shown a high frequency of self-reported facial adverse skin reactions. Case reports have been published on face mask-induced allergic contact dermatitis and urticaria.\n\nTo describe the results of the contact allergy investigations in consecutive HCWs investigated for skin reactions to face masks during the COVID-19 pandemic and the results of the chemical investigations of face masks supplied by the hospital.\n\nParticipants were patch tested with baseline series and chemicals previously reported in face masks not included in the baseline series. Face mask(s) brought by the HCW were tested as is and/or in acetone extract. Chemical analyses were performed on nine different face masks for potential allergens.\n\nFifty-eight HCWs were investigated. No contact allergies were found to the face mask(s) tested. Eczema was the most common type of skin reaction, followed by an acneiform reaction. Colophonium-related substances were found in one respirator and 2,6-di-t-butyl-4-methylphenol (BHT) were found in two respirators.\n\nBased on this report, contact allergies to face masks is uncommon. Patch test with colophonium-related substances and BHT should be considered when investigating adverse skin reactions to face masks.", "doi": "10.1111/cod.14318", "pmid": "37072615", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-20T17:20:30.491Z", "modified": "2023-04-20T17:20:30.634Z"}, {"entity": "publication", "iuid": "17cd812532714081a54e15e64974b1a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/17cd812532714081a54e15e64974b1a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/17cd812532714081a54e15e64974b1a0"}}, "title": "Perceived effects of the COVID-19 pandemic on clinical psychology internships in Sweden.", "authors": [{"family": "Bergvall", "given": "Hillevi", "initials": "H", "orcid": "0000-0003-4091-0757", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41be49533571498f99e4542697b14c65.json"}}, {"family": "Larsson", "given": "Cornelia", "initials": "C", "orcid": "0000-0002-3860-0031", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6b2ff2a74f94af4936beb9bf511c9de.json"}}, {"family": "Str\u00e5lin", "given": "Elinor Eskilsson", "initials": "EE", "orcid": "0000-0002-1194-0968", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29195ee7e8b8468dad955f63f4308f5d.json"}}, {"family": "Bohman", "given": "Benjamin", "initials": "B", "orcid": "0000-0002-3415-7511", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/691b47f0c00d431eb46863b5f5c4b5d2.json"}}, {"family": "Alfonsson", "given": "Sven", "initials": "S", "orcid": "0000-0003-4570-5891", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c3e238a169547c596d13c7199defb7a.json"}}], "type": "journal article", "published": "2023-04-17", "journal": {"title": "BMC Med Educ", "issn": "1472-6920", "volume": "23", "issue": "1", "pages": "249", "issn-l": null}, "abstract": "The COVID-19 pandemic has had an unprecedented impact on societies and health care services worldwide, including the clinical training of psychology interns. Some of the pandemic-related restrictions were in breach of the internship requirements, increasing the risk of failed internships and a shortage of new health care professionals. This situation needed to be assessed.\n\nWeb-based surveys were administered to clinical psychology interns in Sweden 2020 (n = 267) and 2021 (n = 340), as well as to supervisors in 2020 (n = 240). The supervisors also provided information about their interns (n = 297).\n\nRisk factors for a prolonged internship, such as pandemic-related absence from work (12.4% in 2020 and 7.9% in 2021), unqualified work (0% in 2020, 3% in 2021), and change in internship content were low. However, remote interactions using digital services increased. Face-to-face patient contacts decreased significantly from 2020 to 2021 (\u03a72 = 5.17, p = .023), while remote work and remote supervision increased significantly (\u03a72 = 53.86, p < .001 and \u03a72 = 8.88, p = .003, respectively). Still, the content in patient contacts and supervision was maintained. Most interns reported no difficulties with remote supervision or supervision in personal protective equipment. However, of the interns who reported difficulties, role-play and skills training in remote supervision were perceived as significantly harder (\u03a72 = 28.67, p < .001) than in supervision using personal protective equipment.\n\nThe present study indicates that clinical training of psychology interns in Sweden could proceed despite a societal crisis. Results suggest that the psychology internship was flexible in the sense that it could be realized in combined face-to-face and remote formats without losing much of its value. However, the results also suggest that some skills may be harder to train in remote supervision.", "doi": "10.1186/s12909-023-04236-x", "pmid": "37069581", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12909-023-04236-x"}, {"db": "pmc", "key": "PMC10106869"}], "notes": [], "created": "2023-04-20T17:22:13.234Z", "modified": "2023-04-20T17:22:13.409Z"}, {"entity": "publication", "iuid": "469629c631504233b7d149d25ba0b295", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/469629c631504233b7d149d25ba0b295.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/469629c631504233b7d149d25ba0b295"}}, "title": "Impact of the COVID-19 pandemic on sick leave among healthcare workers: a register-based observational study.", "authors": [{"family": "Reme", "given": "Bj\u00f8rn-Atle", "initials": "BA"}, {"family": "Gr\u00f8sland", "given": "Mari", "initials": "M", "orcid": "0000-0001-6992-0620", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b6e933f49c14291aaee6aec14079e70.json"}}, {"family": "Gjefsen", "given": "Hege", "initials": "H"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2023-04-17", "journal": {"title": "Occup Environ Med", "issn": "1470-7926", "issn-l": null}, "abstract": "To assess the impact of the COVID-19 pandemic on sick leave among healthcare workers (HCWs) in primary and specialist care and examine its causes.\n\nUsing individual-level register data, we studied monthly proportions of sick leave (all-cause and not related to SARS-CoV-2 infection) from 2017 to February 2022 for all HCWs in primary (N=60 973) and specialist care (N=34 978) in Norway. First, we estimated the impact of the pandemic on sick leave, by comparing the sick leave rates during the pandemic to sick leave rates in 2017-2019. We then examined the impact of COVID-19-related workload on sick leave, by comparing HCWs working in healthcare facilities with different levels of COVID-19 patient loads.\n\nHCWs had elevated monthly rates of all-cause sick leave during the COVID-19 pandemic of 2.8 (95% CI 2.67 to 2.9) and 2.2 (95% CI 2.07 to 2.35) percentage points in primary and specialist care. The corresponding increases for sick leave not related to SARS-CoV-2 infection were 1.2 (95% CI 1.29 to 1.05) and 0.7 (95% CI 0.52 to 0.78) percentage points. All-cause sick leave was higher in areas with high versus low COVID-19 workloads. However, after removing sick leave episodes due to SARS-CoV-2 infections, there was no difference.\n\nThere was a substantial increase in sick leave among HCWs during the pandemic. Our results suggest that the increase was due to HCWs becoming infected with SARS-CoV-2 and/or sector-wide effects, such as strict infection control measures. More differentiated countermeasures should, therefore, be evaluated to limit capacity constraints in healthcare provision.", "doi": "10.1136/oemed-2022-108555", "pmid": "37068949", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "oemed-2022-108555"}], "notes": [], "created": "2023-04-20T17:22:31.021Z", "modified": "2023-04-20T17:22:39.702Z"}, {"entity": "publication", "iuid": "25bbb9029a374ed995bb6332097b568e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/25bbb9029a374ed995bb6332097b568e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/25bbb9029a374ed995bb6332097b568e"}}, "title": "Myeloperoxidase Inhibition in Heart Failure With Preserved or Mildly Reduced Ejection Fraction: SATELLITE Trial Results.", "authors": [{"family": "Lam", "given": "Carolyn S P", "initials": "CSP"}, {"family": "Lund", "given": "Lars H", "initials": "LH"}, {"family": "Shah", "given": "Sanjiv J", "initials": "SJ"}, {"family": "Voors", "given": "Adriaan A", "initials": "AA"}, {"family": "Erlinge", "given": "David", "initials": "D"}, {"family": "Saraste", "given": "Antti", "initials": "A"}, {"family": "Pirazzi", "given": "Carlo", "initials": "C"}, {"family": "Grove", "given": "Erik L", "initials": "EL"}, {"family": "Barasa", "given": "Anders", "initials": "A"}, {"family": "Schou", "given": "Morten", "initials": "M"}, {"family": "Aziz", "given": "Ahmed", "initials": "A"}, {"family": "Svedlund", "given": "Sara", "initials": "S"}, {"family": "Wijngaarden", "given": "Jan VAN", "initials": "JV"}, {"family": "Lindstedt", "given": "Eva-Lotte", "initials": "EL"}, {"family": "Gustavsson", "given": "Andreas", "initials": "A"}, {"family": "Nelander", "given": "Karin", "initials": "K"}, {"family": "Garkaviy", "given": "Pavlo", "initials": "P"}, {"family": "Gan", "given": "Li-Ming", "initials": "LM"}, {"family": "Gabrielsen", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2023-04-16", "journal": {"title": "J Card Fail", "issn": "1532-8414", "issn-l": null}, "abstract": "Inflammation is a key driver of heart failure (HF) with preserved left ventricular ejection fraction (LVEF). AZD4831 inhibits extracellular myeloperoxidase, reduces inflammation and improves microvascular function in preclinical disease models.\n\nIn this double-blind phase 2a study (SATELLITE; NCT03756285), patients with symptomatic HF, LVEF \u226540%, and elevated B-type natriuretic peptides were randomized 2:1 to once-daily oral AZD4831 5 mg or placebo for 90 days. We aimed to assess target engagement (primary endpoint: myeloperoxidase specific activity) and safety of AZD4831.\n\nDue to COVID-19, the study was terminated early after randomizing 41 patients (median age, 74.0 years; 53.7% male). Myeloperoxidase activity was reduced by >50% from baseline to day 30 and 90 in the AZD4831 group, with a placebo-adjusted reduction of 75% (95% confidence interval: 48, 88; nominal P <0.001). No improvements were noted in secondary/exploratory endpoints, apart from a trend in Kansas City Cardiomyopathy Questionnaire overall summary score. No deaths or treatment-related serious adverse events occurred. AZD4831 treatment-related adverse events were generalized maculopapular rash, pruritus and diarrhoea (all n=1).\n\nAZD4831 inhibited myeloperoxidase and was well tolerated in patients with HF and LVEF \u226540%. Efficacy findings were exploratory due to early termination but warrant further clinical investigation of AZD4831.\n\nFew treatments are available for patients with the forms of heart failure known as 'heart failure with preserved or mildly reduced ejection fraction'. Current treatments do not target inflammation, which may play an important role in this condition. We tested a new drug called AZD4831 (mitiperstat), which reduces inflammation by inhibiting the enzyme myeloperoxidase. Among the 41 patients in our clinical trial, AZD4831 had a good safety profile and inhibited myeloperoxidase by the expected amount. Results mean we can conduct further trials to see whether AZD4831 reduces the symptoms of heart failure and improves patients' ability to take physical exercise.", "doi": "10.1016/j.cardfail.2023.04.003", "pmid": "37072105", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1071-9164(23)00142-2"}], "notes": [], "created": "2023-04-20T17:20:48.792Z", "modified": "2023-04-20T17:20:48.822Z"}, {"entity": "publication", "iuid": "60c043206a064d22b94115553cd77baa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60c043206a064d22b94115553cd77baa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60c043206a064d22b94115553cd77baa"}}, "title": "Nurses and global health responsibility: In light of the COVID-19 pandemic and the war in Ukraine.", "authors": [{"family": "Lindberg", "given": "Catharina", "initials": "C", "orcid": "0000-0001-7552-2717", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c36291c5c6394f01beddc951f2272b88.json"}}, {"family": "Brinchmann", "given": "Berit St\u00f8re", "initials": "BS", "orcid": "0000-0001-6541-4931", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6ed725c0172415f836219836632d987.json"}}], "type": "journal article", "published": "2023-04-15", "journal": {"title": "Int Nurs Rev", "issn": "1466-7657", "issn-l": null}, "abstract": "The aim of this paper was to reflect on global ethical challenges for nurses in light of the COVID-19 pandemic and the war in Ukraine and to discuss 'Nurses and Global Health', a new element in the revised ICN Code of Ethics for Nurses, 2021, and its implications for nurses.\n\nThe authors participated in the latest revision of the Code. When we were revising the ICN Code of Ethics, there was neither an ongoing pandemic nor a war in Europe.\n\nRelevant scientific articles and other academic literature, documents from international organisations, and authors' views.\n\nThe discussion emanated from our reflections on how to actually apply the ICN Code of Ethics, i.e., moving the words from the document itself into everyday practice, in light of the COVID-19 pandemic and the war in Ukraine. In the Code, the nurse's responsibility is highlighted, but there is little or no instruction on how to undertake it.\n\nThe ICN Code of Ethics needs to be operationalised through ethical reflection and discussion in all contexts where nurses work, from policy level to the care environment.", "doi": "10.1111/inr.12844", "pmid": "37060544", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-20T17:23:49.316Z", "modified": "2023-04-20T17:23:49.402Z"}, {"entity": "publication", "iuid": "89c2bbb82ff644319505cb83111e7a28", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/89c2bbb82ff644319505cb83111e7a28.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/89c2bbb82ff644319505cb83111e7a28"}}, "title": "Delayed generation of functional virus-specific circulating T follicular helper cells correlates with severe COVID-19.", "authors": [{"family": "Yu", "given": "Meng", "initials": "M", "orcid": "0000-0002-9798-6624", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b6ab0fe226324dddbb38d008f92767de.json"}}, {"family": "Charles", "given": "Afandi", "initials": "A", "orcid": "0000-0003-0022-3303", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f96e5b81f0ee44938ebf4123dffeba1e.json"}}, {"family": "Cagigi", "given": "Alberto", "initials": "A"}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f2dc27d02294a15a6f691be6aab641f.json"}}, {"family": "\u00d6sterberg", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Falck-Jones", "given": "Sara", "initials": "S"}, {"family": "Azizmohammadi", "given": "Lida", "initials": "L"}, {"family": "\u00c5hlberg", "given": "Eric", "initials": "E"}, {"family": "Falck-Jones", "given": "Ryan", "initials": "R", "orcid": "0000-0002-0985-8658", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b100f8839744b7681180a84162a1625.json"}}, {"family": "Svensson", "given": "Julia", "initials": "J"}, {"family": "Nie", "given": "Mu", "initials": "M"}, {"family": "Warnqvist", "given": "Anna", "initials": "A"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Lenart", "given": "Klara", "initials": "K", "orcid": "0000-0002-4984-2618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/695f9cad72624d87a09626b8097d654d.json"}}, {"family": "Arcoverde Cerveira", "given": "Rodrigo", "initials": "R", "orcid": "0000-0002-1145-2534", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/967497a8624d4a889ba820aa8fe42336.json"}}, {"family": "Ols", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-9784-7176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35eb7b8de6434661a729bab979f26c7d.json"}}, {"family": "Lindgren", "given": "Gustaf", "initials": "G"}, {"family": "Lin", "given": "Ang", "initials": "A"}, {"family": "Maecker", "given": "Holden", "initials": "H", "orcid": "0000-0003-0795-9946", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f643c4e99634951a332a6757953878f.json"}}, {"family": "Bell", "given": "Max", "initials": "M", "orcid": "0000-0001-7464-0324", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/530f7609a1f143b69691db5c41b14412.json"}}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Albert", "given": "Jan", "initials": "J", "orcid": "0000-0001-9020-0521", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79a6c7eedadb4a1e8c6fd7b8b522a8e3.json"}}, {"family": "Sundling", "given": "Christopher", "initials": "C", "orcid": "0000-0002-6138-690X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/95f99b6d6c464221919a437b88b46b54.json"}}, {"family": "Czarnewski", "given": "Paulo", "initials": "P"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "F\u00e4rnert", "given": "Anna", "initials": "A"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K", "orcid": "0000-0001-7679-9494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02d4d3d9ccc547f7ab18ba69493f6a34.json"}}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A", "orcid": "0000-0001-6966-7039", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0c96bf27aca45f6b460a555c5425e2d.json"}}], "type": "journal article", "published": "2023-04-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "2164", "issn-l": "2041-1723"}, "abstract": "Effective humoral immune responses require well-orchestrated B and T follicular helper (Tfh) cell interactions. Whether these interactions are impaired and associated with COVID-19 disease severity is unclear. Here, longitudinal blood samples across COVID-19 disease severity are analysed. We find that during acute infection SARS-CoV-2-specific circulating Tfh (cTfh) cells expand with disease severity. SARS-CoV-2-specific cTfh cell frequencies correlate with plasmablast frequencies and SARS-CoV-2 antibody titers, avidity and neutralization. Furthermore, cTfh cells but not other memory CD4 T cells, from severe patients better induce plasmablast differentiation and antibody production compared to cTfh cells from mild patients. However, virus-specific cTfh cell development is delayed in patients that display or later develop severe disease compared to those with mild disease, which correlates with delayed induction of high-avidity neutralizing antibodies. Our study suggests that impaired generation of functional virus-specific cTfh cells delays high-quality antibody production at an early stage, potentially enabling progression to severe disease.", "doi": "10.1038/s41467-023-37835-9", "pmid": "37061513", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10105364"}, {"db": "pii", "key": "10.1038/s41467-023-37835-9"}], "notes": [], "created": "2023-04-17T14:41:16.708Z", "modified": "2023-04-20T17:23:35.166Z"}, {"entity": "publication", "iuid": "a2c1bd96eca245a49b5934f9d2949300", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2c1bd96eca245a49b5934f9d2949300.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2c1bd96eca245a49b5934f9d2949300"}}, "title": "SARS-CoV-2 Antibodies in Commercial Immunoglobulin Products Show Markedly Reduced Cross-reactivities Against Omicron Variants.", "authors": [{"family": "Lindahl", "given": "Hannes", "initials": "H", "orcid": "0000-0002-4447-9426", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae08b00dd81545eab451b58ce0c0481b.json"}}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE"}, {"family": "Bergman", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2023-04-14", "journal": {"title": "J Clin Immunol", "issn": "1573-2592", "pages": "1-8", "issn-l": "0271-9142"}, "abstract": "Patients with antibody deficiencies often receive maintenance treatment with donor plasma-derived immunoglobulin (Ig) preparations to decrease the incidence and severity of infections. We have previously shown that IgG antibodies to the original SARS-CoV-2 strain were not consistently present in off-the-shelf Ig batches produced up to approximately 18 months after the first identified case of COVID-19 in the USA and that Ig batches with anti-SARS-CoV-2 IgG primarily contained vaccine-induced spike specific antibodies. This study aimed to investigate the degree of cross-reactivity between vaccine-induced anti-SARS-CoV-2 antibodies against Wuhan strain and subsequent viral variants.\n\nSamples were collected from 74 Ig batches supplied by three different commercial manufacturers. All batches were used at the Immunodeficiency Unit at the Karolinska University Hospital from the start of the SARS-CoV-2 pandemic until September 2022. Antibody quantity and potential to neutralize virus entry into host cells were assessed against the original SARS-CoV-2 Wuhan strain and the following nine variants: Alpha, Beta, Delta, IHU, and the Omicron BA.1, BA.1.1, BA.1 with spike mutation L452R, BA.2, and BA.3.\n\nIg batches produced approximately 18 months after the SARS-CoV-2 outbreak (from around July 2021) and later consistently contained high quantities of antibodies that bind the Wuhan strain. The Ig batches had overall low reactivity to the SARS-CoV-2 nucleocapsid, which implies that plasma donor spike IgG essentially is the result of vaccination. We assessed the degree of cross-reactivity towards each virus variant by plotting the variant/Wuhan strain ratio, which was consistent regardless of production date, suggesting cross-reactivity with vaccine-induced antibodies rather than virus exposure in the plasma donor population. Viral variants that emerged later during the pandemic systematically had a lower reactivity ratio, except for the Delta and IHU variants. The Ig batches displayed markedly low neutralizing potential towards the Beta variant and all tested Omicron variants.\n\nCommercial Ig batches currently contain large quantities of SARS-CoV-2 vaccine-induced antibodies. Cross-reactivity with variant strains is evident but varies, with markedly low neutralizing potential observed against Omicron variants.", "doi": "10.1007/s10875-023-01486-8", "pmid": "37058198", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10102687"}, {"db": "pii", "key": "10.1007/s10875-023-01486-8"}], "notes": [], "created": "2023-04-20T17:24:45.566Z", "modified": "2023-04-20T17:25:41.233Z"}, {"entity": "publication", "iuid": "fcd7bbf7cd1043369c2e770f00871b66", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fcd7bbf7cd1043369c2e770f00871b66.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fcd7bbf7cd1043369c2e770f00871b66"}}, "title": "Impact of SARS-CoV-2 vaccination and monoclonal antibodies on outcome post CD19-CAR-T: an EPICOVIDEHA survey.", "authors": [{"family": "van Doesum", "given": "Jaap A", "initials": "JA", "orcid": "0000-0003-0214-3219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49152311cb004139904554d1c096c05c.json"}}, {"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J", "orcid": "0000-0002-6766-8297", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dea501020d2042ad83d1b024987792f4.json"}}, {"family": "Marchesi", "given": "Francesco", "initials": "F"}, {"family": "Di Blasi", "given": "Roberta", "initials": "R", "orcid": "0000-0001-9001-573X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b0e256f42ad4d25aef901a2c2df7eab.json"}}, {"family": "Falces-Romero", "given": "Iker", "initials": "I"}, {"family": "Cabirta", "given": "Alba", "initials": "A", "orcid": "0000-0001-7198-8894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ca8361c64eb4563a0f090faaf569e8a.json"}}, {"family": "Farina", "given": "Francesca", "initials": "F"}, {"family": "Besson", "given": "Caroline", "initials": "C", "orcid": "0000-0003-4364-7173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adc322a60efe4963a3ff76aa00c885d6.json"}}, {"family": "Weinbergerov\u00e1", "given": "Barbora", "initials": "B", "orcid": "0000-0001-6460-2471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7ef50b8f8dc457ab2badd8481b3fa86.json"}}, {"family": "Van Praet", "given": "Jens", "initials": "J", "orcid": "0000-0002-7125-7001", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ebcaace10774e8c8727b0638e5ec075.json"}}, {"family": "Sch\u00f6nlein", "given": "Martin", "initials": "M", "orcid": "0000-0002-1010-0975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bc914f4fd004b8695f47c8ef5373941.json"}}, {"family": "Lopez-Garcia", "given": "Alberto", "initials": "A"}, {"family": "Lamure", "given": "Sylvain", "initials": "S"}, {"family": "Guidetti", "given": "Anna", "initials": "A"}, {"family": "De Ram\u00f3n-S\u00e1nchez", "given": "Cristina", "initials": "C", "orcid": "0000-0002-8167-6410", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d42267ab742491d95080c6592197d6a.json"}}, {"family": "Batinic", "given": "Josip", "initials": "J"}, {"family": "Gavriilaki", "given": "Eleni", "initials": "E", "orcid": "0000-0002-8883-8208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5c146006910e4affb970a1ffe9db5989.json"}}, {"family": "Tragiannidis", "given": "Athanasios", "initials": "A"}, {"family": "Tisi", "given": "Maria Chiara", "initials": "MC"}, {"family": "Plantefeve", "given": "Ga\u00ebtan", "initials": "G"}, {"family": "Petzer", "given": "Verena", "initials": "V", "orcid": "0000-0002-9205-1440", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b52c652fbe2245d1a3df0ca220d8ad98.json"}}, {"family": "Ormazabal-Velez", "given": "Irati", "initials": "I"}, {"family": "Marques de Almeida", "given": "Joyce", "initials": "J", "orcid": "0000-0002-0270-3805", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2459904a9cfe4ea78217373c8af0bea1.json"}}, {"family": "Marchetti", "given": "Monia", "initials": "M"}, {"family": "Maertens", "given": "Johan A", "initials": "JA", "orcid": "0000-0003-4257-5980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4701b45871ba4030a2c57c01edcbf6e0.json"}}, {"family": "Machado", "given": "Marina", "initials": "M", "orcid": "0000-0002-8370-2248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/333e7bffca6c41be995da05411c11248.json"}}, {"family": "Kulasekararaj", "given": "Austin G", "initials": "AG", "orcid": "0000-0003-3180-3570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd4719161efc4d939fe6f4832430a1bc.json"}}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jos\u00e9 \u00c1ngel", "initials": "J\u00c1"}, {"family": "Gomes da Silva", "given": "Maria", "initials": "M", "orcid": "0000-0002-6993-2450", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75ea48d40e3647f189db6f726b4819bc.json"}}, {"family": "Fern\u00e1ndez", "given": "Noem\u00ed", "initials": "N"}, {"family": "Espigado", "given": "Ildefonso", "initials": "I", "orcid": "0000-0002-4043-6613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40c943f7cd0e40998a4a1ae519a39e48.json"}}, {"family": "Drgona", "given": "Lubos", "initials": "L", "orcid": "0000-0002-5089-3201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/746b17dbdf2a4b178e6a11454778c725.json"}}, {"family": "Dragonetti", "given": "Giulia", "initials": "G"}, {"family": "Metafuni", "given": "Elisabetta", "initials": "E", "orcid": "0000-0002-4780-1273", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96f59852bc434fb6968356ec092e911b.json"}}, {"family": "Calbacho", "given": "Maria", "initials": "M"}, {"family": "Blennow", "given": "Ola", "initials": "O", "orcid": "0000-0002-7167-7882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2318c3973e66443aa14fceca0908d127.json"}}, {"family": "Wolf", "given": "Dominik", "initials": "D"}, {"family": "van Anrooij", "given": "Bjorn", "initials": "B"}, {"family": "Nunes Rodrigues", "given": "Raquel", "initials": "R"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Mart\u00edn-Gonz\u00e1lez", "given": "Juan-Alberto", "initials": "JA", "orcid": "0000-0002-3734-921X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a309fa9dc9d4f1c93bd9821205a2f72.json"}}, {"family": "Lievin", "given": "Rapha\u00ebl", "initials": "R", "orcid": "0000-0002-5097-591X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d190434cf5f428f9714a761a1b67889.json"}}, {"family": "Jim\u00e9nez", "given": "Moraima", "initials": "M", "orcid": "0000-0003-1444-8562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c9e09b030ce4f8480230679f8c643be.json"}}, {"family": "Grafe", "given": "Stefanie K", "initials": "SK", "orcid": "0000-0001-7678-0179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6f9279444f64b529761a37a0d2448f4.json"}}, {"family": "Garcia-Sanz", "given": "Ramon", "initials": "R"}, {"family": "C\u00f3rdoba", "given": "Ra\u00fal", "initials": "R"}, {"family": "Rahimli", "given": "Laman", "initials": "L"}, {"family": "van Meerten", "given": "Tom", "initials": "T"}, {"family": "Cornely", "given": "Oliver A", "initials": "OA", "orcid": "0000-0001-9599-3137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3c62d8346924e69b6c99e4007c3831c.json"}}, {"family": "Pagano", "given": "Livio", "initials": "L", "orcid": "0000-0001-8287-928X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbf92a9779614910aeafcc6c21d880e2.json"}}], "type": "journal article", "published": "2023-04-14", "journal": {"title": "Blood Adv", "issn": "2473-9537", "issn-l": null}, "abstract": "Patients with previous CD19 directed chimeric antigen receptor T cell therapy (CAR T)-cell therapy have a prolonged vulnerability to viral infections. Coronavirus diseases 2019 (COVID-19) has a great impact and has previously been shown to cause high mortality in this population. Until now, real world data of the impact of vaccination and treatment on patients with COVID-19 after CD19 directed CAR T-cell therapy are lacking. Therefore, this multicenter retrospective study was conducted with data from the EPICOVIDEHA survey. Sixty-four patients were identified. The overall mortality caused by COVID-19 was 31%. Patients infected with the Omicron variant had a significantly lower risk of death due to COVID-19 compared to patients infected with previous variants (7% versus 58% (P=0.012)). Twenty-six patients were vaccinated at time of COVID-19 diagnosis. Two vaccinations showed marked but unsignificant reduction risk of COVID-19 caused mortality (33.3% versus 14.2% (P=0.379)).Also the course of disease appears milder with less frequent ICU admissions (39% versus 14% (P=0.054)) and shorter duration of hospitalization (7 versus 27.5 days (P=0.022)). Of the available treatment options, only monoclonal antibodies seemed to be effectively reducing mortality from 32% to zero (P=0.036). We conclude that survival rates of CAR T-cell recipients with COVID-19 improved over time and that the combination of prior vaccination and monoclonal antibody treatment significantly reduces their risk of death.", "doi": "10.1182/bloodadvances.2022009578", "pmid": "37058479", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "495340"}], "notes": [], "created": "2023-04-20T17:24:06.886Z", "modified": "2023-04-20T17:25:18.658Z"}, {"entity": "publication", "iuid": "e61559363def444894ce2eac0fa0c060", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e61559363def444894ce2eac0fa0c060.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e61559363def444894ce2eac0fa0c060"}}, "title": "Better Anti-Spike IgG Antibody Response to SARS-CoV-2 Vaccine in Patients on Haemodiafiltration than on Haemodialysis.", "authors": [{"family": "Carrera", "given": "Fernando", "initials": "F"}, {"family": "Jacobson", "given": "Stefan H", "initials": "SH"}, {"family": "Costa", "given": "Joana", "initials": "J"}, {"family": "Marques", "given": "Marco", "initials": "M"}, {"family": "Ferrer", "given": "Francisco", "initials": "F"}], "type": "journal article", "published": "2023-04-14", "journal": {"title": "Blood Purif", "issn": "1421-9735", "pages": "1-8", "issn-l": null}, "abstract": "The antibody response to SARS-CoV-2 vaccine in haemodialysis (HD) patients is diminished compared to healthy subjects. The aim of this study was to compare the presence of reactive SARS-CoV-2 antibodies in patients with high-flux HD and on-line haemodiafiltration (HDF) three and 6 months after the second dose of SARS-CoV-2 vaccine since previous studies indicate that a sustained antibody response correlates with protection from disease.\n\nWe included 216 HD patients of which 157 had on-line HDF and 59 high-flux HD and 46 health care workers as controls and studied the presence of reactive anti-spike IgG antibodies three and 6 months after the second dose of SARS-CoV-2 vaccine. Clinical features between the patient groups were similar, but patients with on-line HDF had significantly higher Kt/V.\n\nThe percentage of participants with reactive antibodies was significantly lower in patients compared to controls, both three and 6 months after the second dose of vaccine. Furthermore, the proportion of patients with reactive anti-spike IgG \u22651.0 6 months after the second dose of vaccine was significantly higher in patients with on-line HDF compared to in patients with high-flux HD. In logistic regression analyses adjusted for several clinical features, the variables associated with presence of reactive anti-spike IgG at 3 months after the second dose of vaccine were lower age, HDF treatment, not being obese and not having a previous solid organ transplant. The two variables with the strongest influence on the presence of reactive anti-spike IgG levels 6 months after the second dose of vaccine were treatment with on-line HDF and not having immunosuppressive therapy.\n\nThis is the first study to show that on-line HDF preserves the antibody response better than high-flux HD after vaccination with SARS-CoV-2 vaccine. Treatment strategies that sustain the vaccine response are essential to apply in this vulnerable group of patients.", "doi": "10.1159/000529719", "pmid": "37062269", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "000529719"}], "notes": [], "created": "2023-04-20T17:23:13.282Z", "modified": "2023-04-20T17:23:13.295Z"}, {"entity": "publication", "iuid": "98d740c575f5461fb34c0f42799c3a1c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/98d740c575f5461fb34c0f42799c3a1c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/98d740c575f5461fb34c0f42799c3a1c"}}, "title": "Prevalence of long COVID complaints in persons with and without COVID-19.", "authors": [{"family": "Magnusson", "given": "Karin", "initials": "K"}, {"family": "Turkiewicz", "given": "Aleksandra", "initials": "A"}, {"family": "Flottorp", "given": "Signe Agnes", "initials": "SA"}, {"family": "Englund", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2023-04-13", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "13", "issue": "1", "pages": "6074", "issn-l": "2045-2322"}, "abstract": "We studied the prevalence and patterns of typical long COVID complaints in ~ 2.3 million individuals aged 18-70 years with and without confirmed COVID-19 in a Nation-wide population-based prospective cohort study in Norway. Our main outcome measures were the period prevalence of single-occurring or different combinations of complaints based on medical records: (1) Pulmonary (dyspnea and/or cough), (2) Neurological (concentration problems, memory loss), and/or (3) General complaints (fatigue). In persons testing positive (n = 75 979), 64 (95% confidence interval: 54 to 73) and 122 (111 to 113) more persons per 10 000 persons had pulmonary complaints 5-6 months after the test compared to 10 000 persons testing negative (n = 1 167 582) or untested (n = 1 084 578), respectively. The corresponding difference in prevalence of general complaints (fatigue) was 181 (168 to 195) and 224 (211 to 238) per 10 000, and of neurological complaints 5 (2 to 8) and 9 (6-13) per 10 000. Overlap between complaints was rare. Long COVID complaints were only slightly more prevalent in persons with than without confirmed COVID-19. Still, long COVID may pose a substantial burden to healthcare systems in the future given the lasting high incidence of symptomatic COVID-19 in both vaccinated and unvaccinated individuals.", "doi": "10.1038/s41598-023-32636-y", "pmid": "37055494", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC10100609"}, {"db": "pii", "key": "10.1038/s41598-023-32636-y"}], "notes": [], "created": "2023-04-20T17:26:10.891Z", "modified": "2023-04-20T17:26:10.896Z"}, {"entity": "publication", "iuid": "8d443acded49416b84400eec2820cb88", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d443acded49416b84400eec2820cb88.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d443acded49416b84400eec2820cb88"}}, "title": "Impact assessment of immunization and the COVID-19 pandemic on varicella across Europe using digital epidemiology methods: A descriptive study.", "authors": [{"family": "Sabale", "given": "Ugne", "initials": "U", "orcid": "0000-0003-1874-8730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8386a4d80734ee5bb684d2405977d75.json"}}, {"family": "Jarmale", "given": "Ligita", "initials": "L"}, {"family": "Murtagh", "given": "Janice", "initials": "J"}, {"family": "Pawaskar", "given": "Manjiri", "initials": "M"}, {"family": "Bencina", "given": "Goran", "initials": "G", "orcid": "0000-0001-6293-8211", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b5e3d769bcd43b9a8a76b70188ad470.json"}}], "type": "journal article", "published": "2023-04-12", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "18", "issue": "4", "pages": "e0283465", "issn-l": "1932-6203"}, "abstract": "Varicella is usually a mild disease in children but may be life-threatening, especially in adolescents and adults. Infection control measures implemented during the Coronavirus Disease 2019 (COVID-19) pandemic may have suppressed varicella transmission, potentially creating an 'immunity debt', particularly in countries without universal varicella vaccination.\n\nTo assess trends in Google search engine queries for varicella keywords as a proxy for varicella infection rates and to evaluate the effect of universal varicella vaccination on these trends. A further objective was to assess the impact of the COVID-19 pandemic on varicella keyword search query trends in countries with and without universal varicella vaccination.\n\nThis study used the keyword research tool, Google Trends, to evaluate trends in time series of the relative search query popularity of language-specific varicella keywords in 28 European countries from January 2015 through December 2021. The Google Ads Keyword Planner tool was used to evaluate absolute search volumes from March 2018 through December 2021.\n\nThe relative search query popularity of varicella keywords displayed marked seasonal variation. In all 28 countries, the relative search query popularity of varicella keywords declined after the start of the COVID-19 pandemic (March 2020), compared with pre-pandemic levels (range, -18% to -70%). From April 2020 to July 2021, a period of intense COVID-19 transmission and infection control, absolute search volumes for varicella keywords were lower than pre-pandemic levels but rebounded after July 2021, when infection control measures were relaxed.\n\nThis evaluation of search query trends demonstrated that search query data could be used as a proxy for trends in varicella infection rates and revealed that transmission of varicella may have been suppressed during the COVID-19 pandemic. Consideration should be given to using search query data to better understand the burden of varicella, particularly in countries where surveillance systems are inadequate.", "doi": "10.1371/journal.pone.0283465", "pmid": "37043422", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10096188"}, {"db": "pii", "key": "PONE-D-22-28976"}], "notes": [], "created": "2023-04-20T17:26:54.270Z", "modified": "2023-04-20T17:27:04.009Z"}, {"entity": "publication", "iuid": "781d1e6d1305446697e712e4bce7cb83", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/781d1e6d1305446697e712e4bce7cb83.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/781d1e6d1305446697e712e4bce7cb83"}}, "title": "Subclass-switched anti-spike IgG3 oligoclonal cocktails strongly enhance Fc-mediated opsonization.", "authors": [{"family": "Izadi", "given": "Arman", "initials": "A", "orcid": "0000-0002-0262-1017", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d36b0ac6385471b917f3be9131d4d57.json"}}, {"family": "Hailu", "given": "Arsema", "initials": "A"}, {"family": "Godzwon", "given": "Magdalena", "initials": "M", "orcid": "0000-0002-9745-1160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/386a6fc861e64386bf32de44d013277f.json"}}, {"family": "Wrighton", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-3378-7925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/740aa0208cea4c27a4297849cec4f9f9.json"}}, {"family": "Olofsson", "given": "Berit", "initials": "B", "orcid": "0009-0009-0602-2183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8cdf27b432648f3957550c8b99bc5b2.json"}}, {"family": "Schmidt", "given": "Tobias", "initials": "T"}, {"family": "S\u00f6derlund-Strand", "given": "Anna", "initials": "A", "orcid": "0009-0001-8886-4385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32d681c0fc724de18f0839cbc41f4f34.json"}}, {"family": "Elder", "given": "Elizabeth", "initials": "E", "orcid": "0000-0003-1615-2642", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f34193310b964fe4b87f65ca04193939.json"}}, {"family": "Appelberg", "given": "Sofia", "initials": "S", "orcid": "0000-0002-7381-3606", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a3e2ab8513742af91714b79b472734a.json"}}, {"family": "Valsj\u00f6", "given": "Maria", "initials": "M"}, {"family": "Larsson", "given": "Olivia", "initials": "O"}, {"family": "Wendel-Hansen", "given": "Vidar", "initials": "V", "orcid": "0009-0002-3179-1565", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e54287872af3447d9d35d0dca01f65b6.json"}}, {"family": "Ohlin", "given": "Mats", "initials": "M", "orcid": "0000-0002-5105-1938", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/def6c0678dfd48ea9a1255a8a00e7ebc.json"}}, {"family": "Bahnan", "given": "Wael", "initials": "W"}, {"family": "Nordenfelt", "given": "Pontus", "initials": "P", "orcid": "0000-0002-9481-9951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe1c1345d0bf4316bead223ad6c9f8a8.json"}}], "type": "journal article", "published": "2023-04-11", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "120", "issue": "15", "pages": "e2217590120", "issn-l": "0027-8424"}, "abstract": "Antibodies play a central role in the immune defense against SARS-CoV-2. Emerging evidence has shown that nonneutralizing antibodies are important for immune defense through Fc-mediated effector functions. Antibody subclass is known to affect downstream Fc function. However, whether the antibody subclass plays a role in anti-SARS-CoV-2 immunity remains unclear. Here, we subclass-switched eight human IgG1 anti-spike monoclonal antibodies (mAbs) to the IgG3 subclass by exchanging their constant domains. The IgG3 mAbs exhibited altered avidities to the spike protein and more potent Fc-mediated phagocytosis and complement activation than their IgG1 counterparts. Moreover, combining mAbs into oligoclonal cocktails led to enhanced Fc- and complement receptor-mediated phagocytosis, superior to even the most potent single IgG3 mAb when compared at equivalent concentrations. Finally, in an in vivo model, we show that opsonic mAbs of both subclasses can be protective against a SARS-CoV-2 infection, despite the antibodies being nonneutralizing. Our results suggest that opsonic IgG3 oligoclonal cocktails are a promising idea to explore for therapy against SARS-CoV-2, its emerging variants, and potentially other viruses.", "doi": "10.1073/pnas.2217590120", "pmid": "37011197", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-04-12T16:48:19.412Z", "modified": "2023-04-12T16:48:36.407Z"}, {"entity": "publication", "iuid": "7481bb67ff36401c896db17824f69322", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7481bb67ff36401c896db17824f69322.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7481bb67ff36401c896db17824f69322"}}, "title": "The impact of Covid-19 in patients with chronic myeloid leukemia-a nationwide population-based study.", "authors": [{"family": "Dahl\u00e9n", "given": "Torsten", "initials": "T", "orcid": "0000-0002-3856-7227", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69a3a4703c134438836a76bd0dec1c68.json"}}, {"family": "Flygt", "given": "Hjalmar", "initials": "H"}, {"family": "L\u00fcbking", "given": "Anna", "initials": "A"}, {"family": "Olsson-Str\u00f6mberg", "given": "Ulla", "initials": "U"}, {"family": "Wennstr\u00f6m", "given": "Lovisa", "initials": "L"}, {"family": "Dreimane", "given": "Arta", "initials": "A"}, {"family": "Sj\u00e4lander", "given": "Anders", "initials": "A", "orcid": "0000-0001-9422-1186", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/290cd473f57946678cf6a391cf58c120.json"}}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Li", "given": "Huiqi", "initials": "H", "orcid": "0000-0002-1127-0829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e3bd3ff6b4e4f448f9332081da1dc29.json"}}, {"family": "H\u00f6glund", "given": "Martin", "initials": "M"}, {"family": "Stenke", "given": "Leif", "initials": "L"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2023-04-10", "journal": {"title": "Leukemia", "issn": "1476-5551", "pages": "1-4", "issn-l": null}, "abstract": null, "doi": "10.1038/s41375-023-01893-1", "pmid": "37037908", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10088575"}, {"db": "pii", "key": "10.1038/s41375-023-01893-1"}], "notes": [], "created": "2023-04-17T14:42:01.368Z", "modified": "2023-04-20T17:29:07.885Z"}, {"entity": "publication", "iuid": "90572370bf5049dba72acc96b9bff5bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90572370bf5049dba72acc96b9bff5bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90572370bf5049dba72acc96b9bff5bd"}}, "title": "The febrile infant: Is it COVID-19 or a serious bacterial infection?", "authors": [{"family": "Ohlin", "given": "Andreas", "initials": "A", "orcid": "0000-0003-0531-6189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ba9ad0ed35f4cbc94aff40e614dbb03.json"}}], "type": "editorial", "published": "2023-04-10", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253"}, "abstract": null, "doi": "10.1111/apa.16783", "pmid": "37035897", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2023-04-20T17:29:19.414Z", "modified": "2023-04-20T17:29:19.451Z"}, {"entity": "publication", "iuid": "e33999b56fec47e29b9dbf27d95de814", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e33999b56fec47e29b9dbf27d95de814.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e33999b56fec47e29b9dbf27d95de814"}}, "title": "Family doctors' roles and perceptions on antibiotic consumption and antibiotic resistance in Romania: a qualitative study.", "authors": [{"family": "Ghiga", "given": "Ioana", "initials": "I"}, {"family": "Pitchforth", "given": "Emma", "initials": "E"}, {"family": "St\u00e5lsby Lundborg", "given": "Cecilia", "initials": "C"}, {"family": "Machowska", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2023-04-10", "journal": {"title": "BMC Prim Care", "issn": "2731-4553", "volume": "24", "issue": "1", "pages": "93", "issn-l": null}, "abstract": "Antimicrobial resistance (AMR) is a major global health issue, bringing significant health burden and costs to societies. Increased antibiotic consumption (ABC) is linked to AMR emergence. Some of the known drivers of ABC are antibiotics over-prescription by physicians and their misuse by patients. Family doctors are recognised as important stakeholders in the control of ABC as they prescribe antibiotics and are considered a reliable source of medical information by patients. Therefore, it is important to explore their perceptions, especially in Romania, which has the highest ABC among European Union Member States. Furthermore, there is no published research exploring Romanian family doctors' perceptions regarding this phenomenon.\n\nThis was a qualitative study with data collection via semi-structured interviews among 12 family doctors. Manifest and latent content analysis was used to gain an in-depth understanding of their perceptions. Findings were mapped onto the domains of the Behaviour Change Wheel to facilitate a theory driven systematization and analysis.\n\nTwo main subthemes emerged: i) factors affecting ABC and prescribing and ii) potential interventions to tackle ABC and antibiotic resistance. The factors were further grouped in those that related to the perceived behaviour of family doctors or patients as well as those that had to do with the various systems, local contexts and the COVID-19 pandemic. An overarching theme: 'family doctors in Romania see their role differently when it comes to antibiotic resistance and perceive the lack of patient education or awareness as one of the major drivers of ABC' was articulated. The main findings suggested that the perceived factors span across the capability, opportunity and motivational domains of the behaviour change wheel and could be addressed through a variety of interventions - some identified by the participants. Findings can also be viewed through cultural lenses which shed further light on the family doctor- patient dynamic when it comes to antibiotics use.\n\nPotential interventions to tackle identified factors emerged, revolving mostly on efforts to educate patients or the public. This exploratory research provides key perspectives and facilitates further research on potential interventions to successfully address AMR in Romania or similar settings.", "doi": "10.1186/s12875-023-02047-z", "pmid": "37038124", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10084585"}, {"db": "pii", "key": "10.1186/s12875-023-02047-z"}], "notes": [], "created": "2023-04-20T17:28:19.348Z", "modified": "2023-04-20T17:28:19.361Z"}, {"entity": "publication", "iuid": "ae8737f2cf2e43f4bde138652616bc8d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ae8737f2cf2e43f4bde138652616bc8d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ae8737f2cf2e43f4bde138652616bc8d"}}, "title": "How Older Persons and Health Care Professionals Co-designed a Medication Plan Prototype Remotely to Promote Patient Safety: Case Study.", "authors": [{"family": "Holmqvist", "given": "Malin", "initials": "M", "orcid": "0000-0003-3221-9800", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1ccb090de9941ef9c9198efe68ae74a.json"}}, {"family": "Ros", "given": "Axel", "initials": "A", "orcid": "0000-0001-6302-8068", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a05b39ead83344668c7baeb3e9b9dae6.json"}}, {"family": "Lindenfalk", "given": "Bertil", "initials": "B", "orcid": "0000-0003-0123-6392", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f070b0a31bfa4d14a84541618e813961.json"}}, {"family": "Thor", "given": "Johan", "initials": "J", "orcid": "0000-0003-1814-4478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a3b8c916bd0496b89cf7d42186d8832.json"}}, {"family": "Johansson", "given": "Linda", "initials": "L", "orcid": "0000-0001-7101-3165", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1af866dfcbe7406ab5785fee6fc740cf.json"}}], "type": "journal article", "published": "2023-04-07", "journal": {"title": "JMIR Aging", "issn": "2561-7605", "volume": "6", "pages": "e41950", "issn-l": null}, "abstract": "Harm from medications is a major patient safety challenge. Most adverse drug events arise when a medication is prescribed or reevaluated. Therefore, interventions in this area may improve patient safety. A medication plan, that is, a plan for continued treatment with medications, may support patient safety. Participation of patients in the design of health care products or services may improve patient safety. Co-design, as in the Double Diamond framework from the Design Council, England, can emphasize patient involvement. As the COVID-19 pandemic brought restrictions to face-to-face co-design approaches, interest in remote approaches increased. However, it is uncertain how best to perform remote co-design. Therefore, we explored a remote approach, which brought together older persons and health care professionals to co-design a medication plan prototype in the electronic health record, aiming to support patient safety.\n\nThis study aimed to describe how remote co-design was applied to create a medication plan prototype and to explore participants' experiences with this approach.\n\nWithin a case study design, we explored the experiences of a remote co-design initiative with 14 participants in a regional health care system in southern Sweden. Using descriptive statistics, quantitative data from questionnaires and web-based workshop timestamps were analyzed. A thematic analysis of the qualitative data gathered from workshops, interviews, and free-text responses to the survey questions was performed. Qualitative and quantitative data were compared side by side in the discussion.\n\nThe analysis of the questionnaires revealed that the participants rated the experiences of the co-design initiative very high. In addition, the balance between how much involved persons expressed their wishes and were listened to was considered very good. Marked timestamps from audio recordings showed that the workshops proceeded according to the plan. The thematic analysis yielded the following main themes: Everyone's perspective matters, Learning by sharing, and Mastering a digital space. The themes encompassed what helped to establish a permissive environment that allowed the participants to be involved and share viewpoints. There was a dynamic process of learning and understanding, realizing that despite different backgrounds, there was consensus about the requirements for a medication plan. The remote co-design process seemed appealing, by balancing opportunities and challenges and building an inviting, creative, and tolerant environment.\n\nParticipants experienced that the remote co-design initiative was inclusive of their perspectives and facilitated learning by sharing experiences. The Double Diamond framework was applicable in a digital context and supported the co-design process of the medication plan prototype. Remote co-design is still novel, but with attentiveness to power relations between all involved, this approach may increase opportunities for older persons and health care professionals to collaboratively design products or services that can improve patient safety.", "doi": "10.2196/41950", "pmid": "37027205", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "v6i1e41950"}], "notes": [], "created": "2023-04-20T17:30:17.565Z", "modified": "2023-04-20T17:30:17.755Z"}, {"entity": "publication", "iuid": "972c0def9aee4a7f9c9497925521940d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/972c0def9aee4a7f9c9497925521940d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/972c0def9aee4a7f9c9497925521940d"}}, "title": "Exploring workplace violence on surgical wards in Sweden: a cross-sectional study.", "authors": [{"family": "Jakobsson", "given": "Jenny", "initials": "J"}, {"family": "\u00d6rmon", "given": "Karin", "initials": "K"}, {"family": "Axelsson", "given": "Malin", "initials": "M"}, {"family": "Berthelsen", "given": "Hanne", "initials": "H"}], "type": "journal article", "published": "2023-04-07", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "volume": "22", "issue": "1", "pages": "106", "issn-l": null}, "abstract": "Workplace violence is a global threat to healthcare professionals' occupational health and safety and the situation has worsened during the COVID-19 pandemic. This study aimed to explore workplace violence directed against assistant and registered nurses working on surgical wards in Sweden.\n\nThis cross-sectional study was conducted in April 2022. Using a convenience sampling procedure, 198 assistant and registered nurses responded to an online questionnaire developed for this specific study. The questionnaire comprised 52 items and included, among other items, subscales from validated and previously used instruments. Data analysis included descriptive statistics, the chi-square test, and independent-samples t-test.\n\nThe most frequently reported type of workplace violence was humiliation (28.8%), followed by physical violence (24.2%), threats (17.7%), and unwanted sexual attention (12.1%). Patients and patients' visitors were reported as the main perpetrators of all kinds of exposure. Additionally, one third of the respondents had experienced humiliation from colleagues. Both threats and humiliation showed negative associations with work motivation and health (p < 0.05). Respondents classified as working in a high- or moderate-risk environment were more frequently exposed to threats (p = 0.025) and humiliation (p = 0.003). Meanwhile, half of the respondents were unaware of any action plans or training regarding workplace violence. However, of those who indicated that they had been exposed to workplace violence, the majority had received quite a lot or a lot of support, mainly from colleagues (range 70.8-80.8%).\n\nDespite a high prevalence of workplace violence, and especially of humiliating acts, there appeared to be low preparedness within the hospital organizations to prevent and/or handle such incidents. To improve these conditions, hospital organizations should place more emphasis on preventive measures as part of their systematic work environment management. To help inform such initiatives, it is suggested that future research should focus on the identification of suitable measures regarding different types of incidents, perpetrators, and settings.", "doi": "10.1186/s12912-023-01275-z", "pmid": "37029387", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10079490"}, {"db": "pii", "key": "10.1186/s12912-023-01275-z"}], "notes": [], "created": "2023-04-20T17:30:03.709Z", "modified": "2023-04-20T17:30:03.725Z"}, {"entity": "publication", "iuid": "654faa31ec7f4ec68d7c29f27107de55", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/654faa31ec7f4ec68d7c29f27107de55.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/654faa31ec7f4ec68d7c29f27107de55"}}, "title": "Study protocol of a phase 2, randomised, placebo-controlled, double-blind, adaptive, parallel group clinical study to evaluate the efficacy and safety of recombinant alpha-1-microglobulin in subjects at high risk for acute kidney injury following open-chest cardiac surgery (AKITA trial).", "authors": [{"family": "Mazer", "given": "C David", "initials": "CD", "orcid": "0000-0003-2566-4308", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4562eb6f8cb94b42ba42985a8e534bc4.json"}}, {"family": "Siadati-Fini", "given": "Niloufar", "initials": "N"}, {"family": "Boehm", "given": "Johannes", "initials": "J"}, {"family": "Wirth", "given": "Felix", "initials": "F"}, {"family": "Myjavec", "given": "Andrej", "initials": "A"}, {"family": "Brown", "given": "Craig D", "initials": "CD"}, {"family": "Koyner", "given": "Jay L", "initials": "JL"}, {"family": "Boening", "given": "Andreas", "initials": "A"}, {"family": "Engelman", "given": "Daniel T", "initials": "DT"}, {"family": "Larsson", "given": "Tobias E", "initials": "TE"}, {"family": "Renfurm", "given": "Ronny", "initials": "R"}, {"family": "de Varennes", "given": "Benoit", "initials": "B"}, {"family": "Noiseux", "given": "Nicolas", "initials": "N"}, {"family": "Thielmann", "given": "Matthias", "initials": "M"}, {"family": "Lamy", "given": "Andre", "initials": "A"}, {"family": "Laflamme", "given": "Maxime", "initials": "M"}, {"family": "von Groote", "given": "Thilo", "initials": "T", "orcid": "0000-0002-5287-1137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c09b4126b4124412b1f727eded281171.json"}}, {"family": "Ronco", "given": "Claudio", "initials": "C"}, {"family": "Zarbock", "given": "Alexander", "initials": "A", "orcid": "0000-0002-2124-1714", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6171146769d4287976ae737bbe755cd.json"}}], "type": "clinical trial protocol", "published": "2023-04-06", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "13", "issue": "4", "pages": "e068363", "issn-l": "2044-6055"}, "abstract": "Acute kidney injury (AKI) is a common complication after cardiac surgery (CS) and is associated with adverse short-term and long-term outcomes. Alpha-1-microglobulin (A1M) is a circulating glycoprotein with antioxidant, heme binding and mitochondrial-protective mechanisms. RMC-035 is a modified, more soluble, variant of A1M and has been proposed as a novel targeted therapeutic protein to prevent CS-associated AKI (CS-AKI). RMC-035 was considered safe and generally well tolerated when evaluated in four clinical phase 1 studies.\n\nThis is a phase 2, randomised, double-blind, adaptive design, parallel group clinical study that evaluates RMC-035 compared with placebo in approximately 268 cardiac surgical patients at high risk for CS-AKI. RMC-035 is administered as an intravenous infusion. In total, five doses will be given. Dosing is based on presurgery estimated glomerular filtration rate (eGFR), and will be either 1.3 or 0.65 mg/kg.The primary study objective is to evaluate whether RMC-035 reduces the incidence of postoperative AKI, and key secondary objectives are to evaluate whether RMC-035 improves postoperative renal function compared with placebo. A blinded interim analysis with potential sample size reassessment is planned once 134 randomised subjects have completed dosing. An independent data monitoring committee will evaluate safety and efficacy data at prespecified intervals throughout the trial. The study is a global multicentre study at approximately 30 sites.\n\nThe trial was approved by the joint ethics committee of the physician chamber Westfalen-Lippe and the University of M\u00fcnster (code '2021-778 f-A') and subsequently approved by the responsible ethics committees/relevant institutional review boards for the participating sites. The study is conducted in accordance with Good Clinical Practice, the Declaration of Helsinki and other applicable regulations. Results of this study will be published in a peer-reviewed scientific journal.\n\nNCT05126303.", "doi": "10.1136/bmjopen-2022-068363", "pmid": "37024249", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2022-068363"}, {"db": "ClinicalTrials.gov", "key": "NCT05126303"}], "notes": [], "created": "2023-04-12T16:47:54.133Z", "modified": "2023-04-12T16:47:54.232Z"}, {"entity": "publication", "iuid": "cedb318e6dfe4c94be75c5c45506300b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cedb318e6dfe4c94be75c5c45506300b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cedb318e6dfe4c94be75c5c45506300b"}}, "title": "Epitopes displayed in a cyclic peptide scaffold bind SARS-CoV-2 antibodies.", "authors": [{"family": "Eriksson", "given": "Camilla", "initials": "C"}, {"family": "Gunasekera", "given": "Sunithi", "initials": "S"}, {"family": "Muhammad", "given": "Taj", "initials": "T"}, {"family": "Zhang", "given": "Mingshu", "initials": "M"}, {"family": "Laur\u00e9n", "given": "Ida", "initials": "I"}, {"family": "Mangsbo", "given": "Sara M", "initials": "SM"}, {"family": "Lord", "given": "Martin", "initials": "M"}, {"family": "G\u00f6ransson", "given": "Ulf", "initials": "U"}], "type": "journal article", "published": "2023-04-06", "journal": {"title": "Chembiochem", "issn": "1439-7633", "issn-l": null, "volume": null, "issue": null, "pages": "e202300103"}, "abstract": "The SARS-CoV-2 virus that causes COVID-19 is a global health issue. The spread of the virus has resulted in more than six million deaths to date. The emergence of new viral strains highlights the importance of continuous surveillance of the SARS-CoV-2 virus, using timely and accurate diagnostic tools. Here, we used stable cyclic peptide scaffolds to present antigenic sequences derived from spike protein, reactive to SARS-CoV-2 antibodies. Using peptide sequences from different domains of SARS-CoV-2 spike protein, we grafted epitopes on the peptide scaffold sunflower trypsin inhibitor 1 (SFTI-1). These scaffold peptides were then used to develop a SARS-CoV-2 ELISA to detect SARS-CoV-2 antibodies in serum. We show that displaying epitopes in the scaffold improves reactivity overall. One of the scaffold peptides (S2_1146-1161_c) has reactivity equal to commercial assays, and shows diagnostic potential.", "doi": "10.1002/cbic.202300103", "pmid": "37021633", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-12T16:47:12.592Z", "modified": "2023-04-20T17:31:28.239Z"}, {"entity": "publication", "iuid": "fedaad814d10430d9d7328bf62b46739", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fedaad814d10430d9d7328bf62b46739.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fedaad814d10430d9d7328bf62b46739"}}, "title": "Electrochemical lateral-flow device for rapid COVID-19 antigen-diagnostic testing.", "authors": [{"family": "Deenin", "given": "Wanwisa", "initials": "W"}, {"family": "Yakoh", "given": "Abdulhadee", "initials": "A"}, {"family": "Pimpitak", "given": "Umaporn", "initials": "U"}, {"family": "Pasomsub", "given": "Ekawat", "initials": "E"}, {"family": "Rengpipat", "given": "Sirirat", "initials": "S"}, {"family": "Crespo", "given": "Gast\u00f3n A", "initials": "GA"}, {"family": "Chaiyo", "given": "Sudkate", "initials": "S"}], "type": "journal article", "published": "2023-04-06", "journal": {"title": "Bioelectrochemistry", "issn": "1878-562X", "volume": "152", "pages": "108438", "issn-l": null}, "abstract": "Antigen test kits (ATK) are extensively utilized for screening and diagnosing COVID-19 because they are easy to operate. However, ATKs exhibit poor sensitivity and cannot detect low concentrations of SARS-CoV-2. Herein, we present a new, highly sensitive, and selective device obtained by combining the principle of ATKs with electrochemical detection for COVID-19 diagnosis, which can be quantitatively assessed using a smartphone. An electrochemical test strip (E-test strip) was constructed by attaching a screen-printed electrode inside a lateral-flow device to exploit the remarkable binding affinity of SARS-CoV-2 antigen to ACE2. The ferrocene carboxylic acid attached to SARS-CoV-2 antibody acts as an electroactive species when it binds to SARS-CoV-2 antigen in the sample before it flows continuously to the ACE2-immobilization region on the electrode. Electrochemical-assay signal intensity on smartphones increased proportionally to the concentration of SARS-CoV-2 antigen (LOD = 2.98 pg/mL, under 12 min). Additionally, the application of the single-step E-test strip for COVID-19 screening was demonstrated using nasopharyngeal samples, and the results were consistent with those obtained using the gold standard (RT-PCR). Therefore, the sensor demonstrated excellent performance in assessing and screening COVID-19, and it can be used professionally to accurately verify diagnostic data while remaining rapid, simple, and inexpensive.", "doi": "10.1016/j.bioelechem.2023.108438", "pmid": "37054603", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10077809"}, {"db": "pii", "key": "S1567-5394(23)00075-0"}], "notes": [], "created": "2023-04-20T17:26:29.972Z", "modified": "2023-04-20T17:26:29.999Z"}, {"entity": "publication", "iuid": "4771f29f0a704723929281738b0b3549", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4771f29f0a704723929281738b0b3549.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4771f29f0a704723929281738b0b3549"}}, "title": "Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.", "authors": [{"family": "Matuozzo", "given": "Daniela", "initials": "D"}, {"family": "Talouarn", "given": "Estelle", "initials": "E"}, {"family": "Marchal", "given": "Astrid", "initials": "A"}, {"family": "Zhang", "given": "Peng", "initials": "P"}, {"family": "Manry", "given": "Jeremy", "initials": "J"}, {"family": "Seeleuthner", "given": "Yoann", "initials": "Y"}, {"family": "Zhang", "given": "Yu", "initials": "Y"}, {"family": "Bolze", "given": "Alexandre", "initials": "A"}, {"family": "Chaldebas", "given": "Matthieu", "initials": "M"}, {"family": "Milisavljevic", "given": "Baptiste", "initials": "B"}, {"family": "Gervais", "given": "Adrian", "initials": "A"}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Asano", "given": "Takaki", "initials": "T"}, {"family": "Bizien", "given": "Lucy", "initials": "L"}, {"family": "Barzaghi", "given": "Federica", "initials": "F"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Abou Tayoun", "given": "Ahmad", "initials": "A"}, {"family": "Aiuti", "given": "Alessandro", "initials": "A"}, {"family": "Alavi Darazam", "given": "Ilad", "initials": "I"}, {"family": "Allende", "given": "Luis M", "initials": "LM"}, {"family": "Alonso-Arias", "given": "Rebeca", "initials": "R"}, {"family": "Arias", "given": "Andr\u00e9s Augusto", "initials": "AA"}, {"family": "Aytekin", "given": "Gokhan", "initials": "G"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Bondesan", "given": "Simone", "initials": "S"}, {"family": "Bryceson", "given": "Yenan T", "initials": "YT"}, {"family": "Bustos", "given": "Ingrid G", "initials": "IG"}, {"family": "Cabrera-Marante", "given": "Oscar", "initials": "O"}, {"family": "Carcel", "given": "Sheila", "initials": "S"}, {"family": "Carrera", "given": "Paola", "initials": "P"}, {"family": "Casari", "given": "Giorgio", "initials": "G"}, {"family": "Cha\u00efbi", "given": "Khalil", "initials": "K"}, {"family": "Colobran", "given": "Roger", "initials": "R"}, {"family": "Condino-Neto", "given": "Antonio", "initials": "A"}, {"family": "Covill", "given": "Laura E", "initials": "LE"}, {"family": "Delmonte", "given": "Ottavia M", "initials": "OM"}, {"family": "El Zein", "given": "Loubna", "initials": "L"}, {"family": "Flores", "given": "Carlos", "initials": "C"}, {"family": "Gregersen", "given": "Peter K", "initials": "PK"}, {"family": "Gut", "given": "Marta", "initials": "M"}, {"family": "Haerynck", "given": "Filomeen", "initials": "F"}, {"family": "Halwani", "given": "Rabih", "initials": "R"}, {"family": "Hancerli", "given": "Selda", "initials": "S"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Hatipo\u011flu", "given": "Nevin", "initials": "N"}, {"family": "Karbuz", "given": "Adem", "initials": "A"}, {"family": "Keles", "given": "Sevgi", "initials": "S"}, {"family": "Kyheng", "given": "Christ\u00e8le", "initials": "C"}, {"family": "Leon-Lopez", "given": "Rafael", "initials": "R"}, {"family": "Franco", "given": "Jose Luis", "initials": "JL"}, {"family": "Mansouri", "given": "Davood", "initials": "D"}, {"family": "Martinez-Picado", "given": "Javier", "initials": "J"}, {"family": "Metin Akcan", "given": "Ozge", "initials": "O"}, {"family": "Migeotte", "given": "Isabelle", "initials": "I"}, {"family": "Morange", "given": "Pierre-Emmanuel", "initials": "PE"}, {"family": "Morelle", "given": "Guillaume", "initials": "G"}, {"family": "Martin-Nalda", "given": "Andrea", "initials": "A"}, {"family": "Novelli", "given": "Giuseppe", "initials": "G"}, {"family": "Novelli", "given": "Antonio", "initials": "A"}, {"family": "Ozcelik", "given": "Tayfun", "initials": "T"}, {"family": "Palabiyik", "given": "Figen", "initials": "F"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}, {"family": "de Diego", "given": "Rebeca P\u00e9rez", "initials": "RP"}, {"family": "Planas-Serra", "given": "Laura", "initials": "L"}, {"family": "Pleguezuelo", "given": "Daniel E", "initials": "DE"}, {"family": "Prando", "given": "Carolina", "initials": "C"}, {"family": "Pujol", "given": "Aurora", "initials": "A"}, {"family": "Reyes", "given": "Luis Felipe", "initials": "LF"}, {"family": "Rivi\u00e8re", "given": "Jacques G", "initials": "JG"}, {"family": "Rodriguez-Gallego", "given": "Carlos", "initials": "C"}, {"family": "Rojas", "given": "Julian", "initials": "J"}, {"family": "Rovere-Querini", "given": "Patrizia", "initials": "P"}, {"family": "Schl\u00fcter", "given": "Agatha", "initials": "A"}, {"family": "Shahrooei", "given": "Mohammad", "initials": "M"}, {"family": "Sobh", "given": "Ali", "initials": "A"}, {"family": "Soler-Palacin", "given": "Pere", "initials": "P"}, {"family": "Tandjaoui-Lambiotte", "given": "Yacine", "initials": "Y"}, {"family": "Tipu", "given": "Imran", "initials": "I"}, {"family": "Tresoldi", "given": "Cristina", "initials": "C"}, {"family": "Troya", "given": "Jesus", "initials": "J"}, {"family": "van de Beek", "given": "Diederik", "initials": "D"}, {"family": "Zatz", "given": "Mayana", "initials": "M"}, {"family": "Zawadzki", "given": "Pawel", "initials": "P"}, {"family": "Al-Muhsen", "given": "Saleh Zaid", "initials": "SZ"}, {"family": "Alosaimi", "given": "Mohammed Faraj", "initials": "MF"}, {"family": "Alsohime", "given": "Fahad M", "initials": "FM"}, {"family": "Baris-Feldman", "given": "Hagit", "initials": "H"}, {"family": "Butte", "given": "Manish J", "initials": "MJ"}, {"family": "Constantinescu", "given": "Stefan N", "initials": "SN"}, {"family": "Cooper", "given": "Megan A", "initials": "MA"}, {"family": "Dalgard", "given": "Clifton L", "initials": "CL"}, {"family": "Fellay", "given": "Jacques", "initials": "J"}, {"family": "Heath", "given": "James R", "initials": "JR"}, {"family": "Lau", "given": "Yu-Lung", "initials": "YL"}, {"family": "Lifton", "given": "Richard P", "initials": "RP"}, {"family": "Maniatis", "given": "Tom", "initials": "T"}, {"family": "Mogensen", "given": "Trine H", "initials": "TH"}, {"family": "von Bernuth", "given": "Horst", "initials": "H"}, {"family": "Lermine", "given": "Alban", "initials": "A"}, {"family": "Vidaud", "given": "Michel", "initials": "M"}, {"family": "Boland", "given": "Anne", "initials": "A"}, {"family": "Deleuze", "given": "Jean-Fran\u00e7ois", "initials": "JF"}, {"family": "Nussbaum", "given": "Robert", "initials": "R"}, {"family": "Kahn-Kirby", "given": "Amanda", "initials": "A"}, {"family": "Mentre", "given": "France", "initials": "F"}, {"family": "Tubiana", "given": "Sarah", "initials": "S"}, {"family": "Gorochov", "given": "Guy", "initials": "G"}, {"family": "Tubach", "given": "Florence", "initials": "F"}, {"family": "Hausfater", "given": "Pierre", "initials": "P"}, {"family": "COVID Human Genetic Effort", "given": "", "initials": ""}, {"family": "COVIDeF Study Group", "given": "", "initials": ""}, {"family": "French COVID Cohort Study Group", "given": "", "initials": ""}, {"family": "CoV-Contact Cohort", "given": "", "initials": ""}, {"family": "COVID-STORM Clinicians", "given": "", "initials": ""}, {"family": "COVID Clinicians", "given": "", "initials": ""}, {"family": "Orchestra Working Group", "given": "", "initials": ""}, {"family": "Amsterdam UMC Covid-19 Biobank", "given": "", "initials": ""}, {"family": "NIAID-USUHS COVID Study Group", "given": "", "initials": ""}, {"family": "Meyts", "given": "Isabelle", "initials": "I"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Puel", "given": "Anne", "initials": "A"}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD"}, {"family": "Boisson-Dupuis", "given": "Stephanie", "initials": "S"}, {"family": "Su", "given": "Helen C", "initials": "HC"}, {"family": "Boisson", "given": "Bertrand", "initials": "B"}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL"}, {"family": "Zhang", "given": "Qian", "initials": "Q"}, {"family": "Abel", "given": "Laurent", "initials": "L"}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5369fe152ac94b5a81d4f913d85940a7.json"}}], "type": "journal article", "published": "2023-04-05", "journal": {"title": "Genome Med", "issn": "1756-994X", "issn-l": null, "volume": "15", "issue": "1", "pages": "22"}, "abstract": "We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases.\n\nWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.\n\nNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P = 1.1 \u00d7 10-4) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3-8.2], P = 2.1 \u00d7 10-4). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1-2635.4], P = 3.4 \u00d7 10-3), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3-8.4], P = 7.7 \u00d7 10-8). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 \u00d7 10-5).\n\nRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.", "doi": "10.1186/s13073-023-01173-8", "pmid": "37020259", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10074346"}, {"db": "pii", "key": "10.1186/s13073-023-01173-8"}, {"db": "ClinicalTrials.gov", "key": "NCT04262921"}, {"db": "ClinicalTrials.gov", "key": "NCT04259892"}, {"db": "ClinicalTrials.gov", "key": "NCT04352348"}], "notes": [], "created": "2023-04-12T16:45:00.367Z", "modified": "2023-06-19T15:33:16.774Z"}, {"entity": "publication", "iuid": "ebd0517b643c4bd296f4066e7bd2a421", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ebd0517b643c4bd296f4066e7bd2a421.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ebd0517b643c4bd296f4066e7bd2a421"}}, "title": "Progress in vaccine development for infectious diseases-a Keystone Symposia report.", "authors": [{"family": "Cable", "given": "Jennifer", "initials": "J"}, {"family": "Graham", "given": "Barney S", "initials": "BS"}, {"family": "Koup", "given": "Richard A", "initials": "RA"}, {"family": "Seder", "given": "Robert A", "initials": "RA"}, {"family": "Karik\u00f3", "given": "Katalin", "initials": "K"}, {"family": "Pardi", "given": "Norbert", "initials": "N"}, {"family": "Barouch", "given": "Dan H", "initials": "DH"}, {"family": "Sharma", "given": "Bhawna", "initials": "B"}, {"family": "Rauch", "given": "Susanne", "initials": "S"}, {"family": "Nachbagauer", "given": "Raffael", "initials": "R"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Schotsaert", "given": "Michael", "initials": "M"}, {"family": "Ellebedy", "given": "Ali H", "initials": "AH"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "Irvine", "given": "Darrell J", "initials": "DJ"}, {"family": "Pilkington", "given": "Emily", "initials": "E"}, {"family": "Tahtinen", "given": "Siri", "initials": "S"}, {"family": "Thompson", "given": "Elizabeth A", "initials": "EA"}, {"family": "Feraoun", "given": "Yanis", "initials": "Y"}, {"family": "King", "given": "Neil P", "initials": "NP"}, {"family": "Saunders", "given": "Kevin", "initials": "K"}, {"family": "Alter", "given": "Galit", "initials": "G"}, {"family": "Moin", "given": "Syed M", "initials": "SM"}, {"family": "Sliepen", "given": "Kwinten", "initials": "K"}, {"family": "Hedestam", "given": "Gunilla B Karlsson", "initials": "GBK"}, {"family": "Wardemann", "given": "Hedda", "initials": "H"}, {"family": "Pulendran", "given": "Bali", "initials": "B"}, {"family": "Doria-Rose", "given": "Nicole A", "initials": "NA"}, {"family": "He", "given": "Wan-Ting", "initials": "WT"}, {"family": "Juno", "given": "Jennifer A", "initials": "JA"}, {"family": "Ataca", "given": "Sila", "initials": "S"}, {"family": "Wheatley", "given": "Adam K", "initials": "AK"}, {"family": "McLellan", "given": "Jason S", "initials": "JS"}, {"family": "Walker", "given": "Laura M", "initials": "LM"}, {"family": "Lederhofer", "given": "Julia", "initials": "J"}, {"family": "Lindesmith", "given": "Lisa C", "initials": "LC"}, {"family": "Wille", "given": "Holger", "initials": "H"}, {"family": "Hotez", "given": "Peter J", "initials": "PJ"}, {"family": "Bekker", "given": "Linda-Gail", "initials": "LG"}], "type": "journal article", "published": "2023-04-05", "journal": {"title": "Ann N Y Acad Sci", "issn": "1749-6632", "issn-l": null}, "abstract": "The COVID-19 pandemic has taught us many things, among the most important of which is that vaccines are one of the cornerstones of public health that help make modern longevity possible. While several different vaccines have been successful at stemming the morbidity and mortality associated with various infectious diseases, many pathogens/diseases remain recalcitrant to the development of effective vaccination. Recent advances in vaccine technology, immunology, structural biology, and other fields may yet yield insight that will address these diseases; they may also help improve societies' preparedness for future pandemics. On June 1-4, 2022, experts in vaccinology from academia, industry, and government convened for the Keystone symposium \"Progress in Vaccine Development for Infectious Diseases\" to discuss state-of-the-art technologies, recent advancements in understanding vaccine-mediated immunity, and new aspects of antigen design to aid vaccine effectiveness.", "doi": "10.1111/nyas.14975", "pmid": "37020354", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-04-12T16:57:16.013Z", "modified": "2023-04-12T16:57:16.028Z"}, {"entity": "publication", "iuid": "e9de182c54464427a9bcf42df7f187b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e9de182c54464427a9bcf42df7f187b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e9de182c54464427a9bcf42df7f187b0"}}, "title": "The impact of immunomodulating treatment on the immunogenicity of COVID-19 vaccines in patients with immune-mediated inflammatory rheumatic diseases compared to healthy controls. A Swedish nationwide study (COVID19-REUMA).", "authors": [{"family": "Frodlund", "given": "Martina", "initials": "M"}, {"family": "Nived", "given": "Per", "initials": "P"}, {"family": "Chatzidionysiou", "given": "Aikaterini", "initials": "A"}, {"family": "S\u00f6dergren", "given": "Anna", "initials": "A"}, {"family": "Klingberg", "given": "Eva", "initials": "E"}, {"family": "Bengtsson", "given": "Anders", "initials": "A"}, {"family": "Hansson", "given": "Monika", "initials": "M"}, {"family": "Olsson", "given": "Sophie", "initials": "S"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Klareskog", "given": "Lars", "initials": "L"}, {"family": "Kapetanovic", "given": "Meliha C", "initials": "MC"}], "type": "journal article", "published": "2023-04-04", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null}, "abstract": "To elucidate antibody responses after the second and third dose of COVID-19 vaccine in patients with inflammatory rheumatic diseases (IRD) treated with biologic/targeted disease modifying anti-rheumatic drugs (b/ts DMARDs).\n\nAntibody levels to antigens representing spike full length protein and spike S1 were measured before vaccination, 2-12 weeks after the second dose, before and after the third dose using multiplex bead-based serology assay. Positive antibody response was defined as antibody levels over cut off (seropositivity) in seronegative individuals or \u2265 4-fold increase in antibodies in individuals seropositive for both spike proteins.\n\nPatients (n = 414) receiving b/ts DMARDs (283 had arthritis, 75 systemic vasculitis and 56 other autoimmune diseases) and controls (n = 61) from five Swedish regions participated. Treatments groups were: rituximab (n = 145); abatacept (n = 22); Interleukin 6 receptor inhibitors [IL6i (n = 79)]; JAnus Kinase Inhibitors [JAKi (n = 58)], Tumour Necrosis Factor inhibitor [TNFi (n = 68)] and Interleukin12/23/17 inhibitors [IL12/23/17i (n = 42)]. Percentage of patients with positive antibody response after two doses was significantly lower in rituximab (33,8%) and abatacept (40,9%) (p < 0,001) but not in IL12/23/17i, TNFi or JAKi groups compared to controls (80,3%). Higher age, rituximab treatment and shorter time between last rituximab course and vaccination predicted impaired antibody response. Antibody levels collected 21-40 weeks after second dose decreased significantly (IL6i: p = 0,02; other groups: p < 0,001) compared to levels at 2-12 week but most participants remained seropositive. Proportion of patients with positive antibody response increased after third dose but was still significantly lower in rituximab (p < 0,001).\n\nOlder individuals and patients on maintenance rituximab have an impaired response after two doses of COVID-19 vaccine which improves if the time between last rituximab course and vaccination extends and also after an additional vaccine dose. Rituximab patients should be prioritized for booster vaccine doses. TNFi, JAKi and IL12/23/17i does not diminished humoral response to primary and an additional vaccination.", "doi": "10.1016/j.vaccine.2023.03.065", "pmid": "37076360", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(23)00372-9"}], "notes": [], "created": "2023-04-20T17:19:58.707Z", "modified": "2023-04-20T17:19:58.711Z"}, {"entity": "publication", "iuid": "cfbc238647cc44adbd0dec991239d3af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfbc238647cc44adbd0dec991239d3af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfbc238647cc44adbd0dec991239d3af"}}, "title": "Risk of venous thromboembolism in patients with COVID-19 during 2020; a retrospective cross-sectional study in a Swedish health care system.", "authors": [{"family": "Wretborn", "given": "Jens", "initials": "J"}, {"family": "J\u00f6rg", "given": "Matthias", "initials": "M"}, {"family": "Benjaminsson Nyberg", "given": "Patrik", "initials": "P"}, {"family": "Wilhelms", "given": "Daniel B", "initials": "DB"}], "type": "observational study", "published": "2023-04-04", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "13", "issue": "1", "pages": "5469", "issn-l": "2045-2322"}, "abstract": "To establish the impact of COVID-19 on the pre-test probability for VTE in patients with suspected VTE. This was a retrospective, observational, cross-sectional study of patients 18 years and older undergoing diagnostic tests for VTE in an integrated healthcare system covering a population of 465,000 during the calendar year of 2020. We adjusted for risk factors such as age, sex, previous VTE, ongoing anticoagulant treatment, malignancy, Charlson score, ward care, ICU care and wave of COVID-19. In total, 303 of 5041 patients had a positive diagnosis of COVID-19 around the time of investigation. The prevalence of VTE in COVID-positive patients was 10.2% (36/354), 14.7% (473/3219) in COVID-19 negative patients, and 15.6% (399/2589) in patients without a COVID-19 test. A COVID-positive status was not associated with an increased risk for VTE (crude odds ratio 0.64, 95% CI 0.45-0.91, adjusted odds ratio 0.46, 95%CI 0.19-1.16). We found no increased VTE risk in COVID-positive patients. This indicates that COVID-19 status should not influence VTE workup.The study was pre-registered on May 26, 2020 at ClinicalTrials.gov with identifier NCT04400877.", "doi": "10.1038/s41598-023-32637-x", "pmid": "37015984", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10071240"}, {"db": "pii", "key": "10.1038/s41598-023-32637-x"}, {"db": "ClinicalTrials.gov", "key": "NCT04400877"}], "notes": [], "created": "2023-04-20T17:34:09.863Z", "modified": "2023-04-20T17:34:31.386Z"}, {"entity": "publication", "iuid": "8fb56fd42b8c40bab2e6d38faf82c335", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8fb56fd42b8c40bab2e6d38faf82c335.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8fb56fd42b8c40bab2e6d38faf82c335"}}, "title": "The influence of meteorological factors on COVID-19 spread in Italy during the first and second wave.", "authors": [{"family": "Balboni", "given": "Erica", "initials": "E"}, {"family": "Filippini", "given": "Tommaso", "initials": "T"}, {"family": "Rothman", "given": "Kenneth J", "initials": "KJ"}, {"family": "Costanzini", "given": "Sofia", "initials": "S"}, {"family": "Bellino", "given": "Stefania", "initials": "S"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Brusaferro", "given": "Silvio", "initials": "S"}, {"family": "Ferrari", "given": "Fabrizio", "initials": "F"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}, {"family": "Teggi", "given": "Sergio", "initials": "S"}, {"family": "Vinceti", "given": "Marco", "initials": "M"}], "type": "journal article", "published": "2023-04-03", "journal": {"title": "Environ Res", "issn": "1096-0953", "volume": "228", "pages": "115796", "issn-l": "0013-9351"}, "abstract": "The relation between meteorological factors and COVID-19 spread remains uncertain, particularly with regard to the role of temperature, relative humidity and solar ultraviolet (UV) radiation. To assess this relation, we investigated disease spread within Italy during 2020. The pandemic had a large and early impact in Italy, and during 2020 the effects of vaccination and viral variants had not yet complicated the dynamics. We used non-linear, spline-based Poisson regression of modeled temperature, UV and relative humidity, adjusting for mobility patterns and additional confounders, to estimate daily rates of COVID-19 new cases, hospital and intensive care unit admissions, and deaths during the two waves of the pandemic in Italy during 2020. We found little association between relative humidity and COVID-19 endpoints in both waves, whereas UV radiation above 40 kJ/m2 showed a weak inverse association with hospital and ICU admissions in the first wave, and a stronger relation with all COVID-19 endpoints in the second wave. Temperature above 283 K (10 \u00b0C/50 \u00b0F) showed a strong non-linear negative relation with COVID-19 endpoints, with inconsistent relations below this cutpoint in the two waves. Given the biological plausibility of a relation between temperature and COVID-19, these data add support to the proposition that temperature above 283 K, and possibly high levels of solar UV radiation, reduced COVID-19 spread.", "doi": "10.1016/j.envres.2023.115796", "pmid": "37019296", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10069087"}, {"db": "pii", "key": "S0013-9351(23)00588-1"}], "notes": [], "created": "2023-04-20T17:32:35.870Z", "modified": "2023-04-20T17:32:35.873Z"}, {"entity": "publication", "iuid": "247606a2b6ef4131a55e51ce4a162a24", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/247606a2b6ef4131a55e51ce4a162a24.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/247606a2b6ef4131a55e51ce4a162a24"}}, "title": "Missed opportunities in using lessons from HIV response to combat COVID-19 - looking back while preparing for the next pandemic.", "authors": [{"family": "Panakadan", "given": "Salil", "initials": "S"}, {"family": "Gun", "given": "Arkaprabha", "initials": "A"}, {"family": "Sarkar", "given": "Swarup", "initials": "S"}], "type": "journal article", "published": "2023-04-03", "journal": {"title": "Indian J Med Res", "issn": "0971-5916", "issn-l": null}, "abstract": null, "doi": "10.4103/ijmr.ijmr_313_23", "pmid": "37006024", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "373426"}], "notes": [], "created": "2023-04-20T17:39:44.490Z", "modified": "2023-04-20T17:39:44.507Z"}, {"entity": "publication", "iuid": "e9fd703334084370af67f4e335bed340", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e9fd703334084370af67f4e335bed340.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e9fd703334084370af67f4e335bed340"}}, "title": "Flares after COVID-19 infection in patients with idiopathic inflammatory myopathies: results from the COVAD study.", "authors": [{"family": "Ali", "given": "Sasha Saadia", "initials": "SS"}, {"family": "R", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Saha", "given": "Sreoshy", "initials": "S", "orcid": "0000-0001-6745-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00238845dd4833ae51ffb75e2fe144.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Jagtap", "given": "Kshitij", "initials": "K", "orcid": "0000-0003-2729-737X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822b9da98e5d4eb2975ff97fe484933f.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Edgar Gracia-Ramos", "given": "Abraham", "initials": "A", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Chen", "given": "Yi Ming", "initials": "YM", "orcid": "0000-0001-7593-3065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/795f1bf1d4824521a3301f7c50f62bc4.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-0986-8354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2e6226ae5e7427fbf52e180dd14e28f.json"}}, {"family": "Patel", "given": "Aarat", "initials": "A"}, {"family": "Pauling", "given": "John D", "initials": "JD", "orcid": "0000-0002-2793-2364", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e37709273d404d17a88c7c850777b99f.json"}}, {"family": "Wincup", "given": "Chris", "initials": "C", "orcid": "0000-0002-8742-8311", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a674f02e7f7f45f58167eb24f81502f3.json"}}, {"family": "Barman", "given": "Bhupen", "initials": "B", "orcid": "0000-0002-5433-1310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7747785ec5fa4743bc70bd20fbca10fd.json"}}, {"family": "Zamora Tehozol", "given": "Erick Adrian", "initials": "EA", "orcid": "0000-0002-7888-3961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a55c695ac4f4003993a2f511cca7739.json"}}, {"family": "Rojas Serrano", "given": "Jorge", "initials": "J", "orcid": "0000-0001-6980-7898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/225fd8b396ac40f4a77f1ec229c086b6.json"}}, {"family": "La Torre", "given": "Ignacio Garc\u00eda-De", "initials": "IG", "orcid": "0000-0002-9261-678X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/086b85d66fb84b50bd51bbe5a979dfe3.json"}}, {"family": "Colunga-Pedraza", "given": "Iris J", "initials": "IJ", "orcid": "0000-0002-2786-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50e46ef2c7f44b39a1d28fea6a8e621d.json"}}, {"family": "Merayo-Chalico", "given": "Javier", "initials": "J", "orcid": "0000-0002-5870-0523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d74c0ab33cbe4df586e1a1add37d0e65.json"}}, {"family": "Chibuzo", "given": "Okwara Celestine", "initials": "OC"}, {"family": "Katchamart", "given": "Wanruchada", "initials": "W", "orcid": "0000-0002-8952-5967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9439933b38fb49aca8fdbb5038ff603c.json"}}, {"family": "Goo", "given": "Phonpen Akawatcharangura", "initials": "PA"}, {"family": "Shumnalieva", "given": "Russka", "initials": "R", "orcid": "0000-0003-2321-6536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/933232cd7feb48ee81b5971f01f52e23.json"}}, {"family": "Hoff", "given": "Leonardo Santos", "initials": "LS", "orcid": "0000-0002-2083-4796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1df7af8caf024ca39c57278fdf18c766.json"}}, {"family": "El Kibbi", "given": "Lina", "initials": "L", "orcid": "0000-0003-1710-9996", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11bb4fc524264c6897dec9642a0ef7cd.json"}}, {"family": "Halabi", "given": "Hussein", "initials": "H", "orcid": "0000-0002-5174-8292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb337090a5ab4461a07e8620bee1b4b9.json"}}, {"family": "Vaidya", "given": "Binit", "initials": "B", "orcid": "0000-0002-4840-8924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b2296d53fe14fc7a8415f26e03e1944.json"}}, {"family": "Shaharir", "given": "Syahrul Sazliyana", "initials": "SS", "orcid": "0000-0002-9068-8114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1e6310979d44d58b548c61c733412af.json"}}, {"family": "Hasan", "given": "A T M Tanveer", "initials": "ATMT", "orcid": "0000-0002-5332-3319", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ffdb3329292438fac4005923ee79012.json"}}, {"family": "Dey", "given": "Dzifa", "initials": "D", "orcid": "0000-0002-3339-5112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2615e43aeba34a0585679bdd14a1a324.json"}}, {"family": "Guti\u00e9rrez", "given": "Carlos Enrique Toro", "initials": "CET", "orcid": "0000-0002-6084-7049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/980e455c5d114caaaefb6e0b55eaa3b3.json"}}, {"family": "Caballero-Uribe", "given": "Carlo Vinicio", "initials": "CV", "orcid": "0000-0002-9845-8620", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42d86c9923424f9a804bab4580b993c3.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "COVAD study group", "given": "", "initials": ""}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}], "type": "journal article", "published": "2023-04-02", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "issn-l": null}, "abstract": null, "doi": "10.1093/rheumatology/kead149", "pmid": "37004201", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7099604"}], "notes": [], "created": "2023-04-20T17:40:10.413Z", "modified": "2023-04-20T17:40:11.317Z"}, {"entity": "publication", "iuid": "229dabd823ed479fb027ca750381cb48", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/229dabd823ed479fb027ca750381cb48.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/229dabd823ed479fb027ca750381cb48"}}, "title": "Setting an Agenda: Results of a Consensus Process on Research Directions in Distance Simulation.", "authors": [{"family": "Gross", "given": "Isabel T", "initials": "IT"}, {"family": "Clapper", "given": "Timothy C", "initials": "TC"}, {"family": "Ramachandra", "given": "Geethanjali", "initials": "G"}, {"family": "Thomas", "given": "Anita", "initials": "A"}, {"family": "Ades", "given": "Anne", "initials": "A"}, {"family": "Walsh", "given": "Barbara", "initials": "B"}, {"family": "Kreuzer", "given": "Florian", "initials": "F"}, {"family": "Elkin", "given": "Rachel", "initials": "R"}, {"family": "Wagner", "given": "Michael", "initials": "M"}, {"family": "Whitfill", "given": "Travis", "initials": "T"}, {"family": "Chang", "given": "Todd P", "initials": "TP"}, {"family": "Duff", "given": "Jonathan P", "initials": "JP"}, {"family": "Deutsch", "given": "Ellen S", "initials": "ES"}, {"family": "Loellgen", "given": "Ruth M", "initials": "RM"}, {"family": "Palaganas", "given": "Janice C", "initials": "JC"}, {"family": "Fayyaz", "given": "Jabeen", "initials": "J"}, {"family": "Kessler", "given": "David", "initials": "D"}, {"family": "Calhoun", "given": "Aaron W", "initials": "AW"}], "type": "review", "published": "2023-04-01", "journal": {"title": "Simul Healthc", "issn": "1559-713X", "volume": "18", "issue": "2", "pages": "100-107", "issn-l": null}, "abstract": "The COVID-19 pandemic forced rapid implementation and refinement of distance simulation methodologies in which participants and/or facilitators are not physically colocated. A review of the distance simulation literature showed that heterogeneity in many areas (including nomenclature, methodology, and outcomes) limited the ability to identify best practice. In April 2020, the Healthcare Distance Simulation Collaboration was formed with the goal of addressing these issues. The aim of this study was to identify future research priorities in the field of distance simulation using data derived from this summit.\n\nThis study analyzed textual data gathered during the consensus process conducted at the inaugural Healthcare Distance Simulation Summit to explore participant perceptions of the most pressing research questions regarding distance simulation. Participants discussed education and patient safety standards, simulation facilitators and barriers, and research priorities. Data were qualitatively analyzed using an explicitly constructivist thematic analysis approach, resulting in the creation of a theoretical framework.\n\nOur sample included 302 participants who represented 29 countries. We identified 42 codes clustered within 4 themes concerning key areas in which further research into distance simulation is needed: (1) safety and acceptability, (2) educational/foundational considerations, (3) impact, and (4) areas of ongoing exploration. Within each theme, pertinent research questions were identified and categorized.\n\nDistance simulation presents several challenges and opportunities. Research around best practices, including educational foundation and psychological safety, are especially important as is the need to determine outcomes and long-term effects of this emerging field.", "doi": "10.1097/SIH.0000000000000663", "pmid": "36989108", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "01266021-202304000-00004"}], "notes": [], "created": "2023-04-21T15:55:55.001Z", "modified": "2023-04-21T15:55:55.021Z"}, {"entity": "publication", "iuid": "f5cdf5e7e60f43279f920149fd093bdc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f5cdf5e7e60f43279f920149fd093bdc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f5cdf5e7e60f43279f920149fd093bdc"}}, "title": "Outcome of SARS-CoV2 infection in hematopoietic stem cell transplant recipients for autoimmune diseases.", "authors": [{"family": "Greco", "given": "Raffaella", "initials": "R"}, {"family": "Snowden", "given": "John A", "initials": "JA"}, {"family": "Knelange", "given": "Nina Simone", "initials": "NS"}, {"family": "Tridello", "given": "Gloria", "initials": "G"}, {"family": "Cacciatore", "given": "Carlotta", "initials": "C"}, {"family": "Xhaard", "given": "Alienor", "initials": "A"}, {"family": "Ciceri", "given": "Fabio", "initials": "F"}, {"family": "Collin", "given": "Matthew", "initials": "M"}, {"family": "Ferra", "given": "Christelle", "initials": "C"}, {"family": "De Becker", "given": "Ann", "initials": "A"}, {"family": "Badoglio", "given": "Manuela", "initials": "M"}, {"family": "Averbuch", "given": "Dina", "initials": "D"}, {"family": "Alexander", "given": "Tobias", "initials": "T"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "De la Camara", "given": "Rafael", "initials": "R"}, {"family": "European Society for Blood and Marrow Transplantation (EBMT) COVID19 Task Force, Autoimmune Diseases Working Party (ADWP) and Infectious Diseases Working Party (IDWP)", "given": "", "initials": ""}], "type": "multicenter study", "published": "2023-04-00", "journal": {"title": "J Autoimmun", "issn": "1095-9157", "volume": "136", "pages": "103024", "issn-l": null}, "abstract": "Hematopoietic stem cell transplant (HSCT) recipients may be at high risk of mortality from coronavirus disease 2019 (COVID-19). However, specific data on COVID-19 after treatment with HSCT in patients affected by autoimmune diseases (ADs) are still lacking. In this multicenter observational study of the European Society for Blood and Marrow Transplantation (EBMT), clinical data on COVID-19 in 11 patients affected by severe ADs treated with HSCT (n = 3 allogeneic transplant; n = 8 autologous transplant) are reported. All patients were symptomatic during the initial phase of the SARS-CoV-2 infection. At screening, 5 patients reported upper respiratory symptoms, 3 patients had cough without oxygen requirement, and 6 patients exhibited extra-pulmonary symptoms. Four cases developed a lower respiratory tract disease (LRTD). Hospitalization was required in 6 cases, without necessity of intensive care unit (ICU) admission and/or ventilation/supplemental oxygen. Different interventions were adopted: remdesivir (n = 1), nirmatrelvir/ritonavir (n = 1), sotrovimab (n = 1), immunoglobulins (n = 1). At last follow-up, all patients are alive and had resolution of the infection. The current analysis describing the mild-moderate course of COVID-19 in transplant recipients affected by ADs, similar to the course observed in ADs under standard treatments, provides useful information to support the delivery of HSCT programs in this field. Vaccination and new treatments available for SARS-CoV-2 may be useful to further minimize the risk of infection.", "doi": "10.1016/j.jaut.2023.103024", "pmid": "37001437", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9977622"}, {"db": "pii", "key": "S0896-8411(23)00033-1"}], "notes": [], "created": "2023-04-20T17:41:50.640Z", "modified": "2023-04-20T17:41:50.654Z"}, {"entity": "publication", "iuid": "6084019b59d24fceb0530a9ee8bfd452", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6084019b59d24fceb0530a9ee8bfd452.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6084019b59d24fceb0530a9ee8bfd452"}}, "title": "Non-communicable disease policy implementation from 2014 to 2021: a repeated cross-sectional analysis of global policy data for 194 countries.", "authors": [{"family": "Allen", "given": "Luke N", "initials": "LN"}, {"family": "Wigley", "given": "Simon", "initials": "S"}, {"family": "Holmer", "given": "Hampus", "initials": "H"}, {"family": "Barlow", "given": "Pepita", "initials": "P"}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "Lancet Glob Health", "issn": "2214-109X", "volume": "11", "issue": "4", "pages": "e525-e533", "issn-l": null}, "abstract": "Non-communicable diseases (NCDs) are the world's leading cause of death and disability. Global implementation of WHO-recommended NCD policies has been increasing with time, but in 2019 fewer than half of these policies had been implemented globally. In 2022, WHO released updated data on NCD policy implementation, on the basis of surveys conducted in 2021 during the COVID-19 pandemic. We sought to examine whether the trajectory of global policy implementation changed during this period.\n\nIn this repeated cross-sectional analysis, we used data from the 2015, 2017, 2020, and 2022 WHO progress monitors to calculate NCD policy implementation scores for all 194 WHO member states. We used Welch's ANOVA and Games-Howell post-hoc pairwise testing to examine changes in mean implementation scores for 19 WHO-recommended NCD policies, with assessment at the global, geographical, geopolitical, and country-income levels. We collated sales data on tobacco, alcohol, and junk foods to examine the association between changes in sales and the predicted probability of implementation of policies targeting these products. We also calculated the Corporate Financial Influence Index (CFII) for each country, which was used to assess the association between corporate influence and policy implementation. We used logistic regression to assess the relationship between product sales and the probability of implementing related policies. The relationship between CFII and policy implementation was assessed with Pearson's correlation analysis and random-effects multivariate regression.\n\nAcross the 194 countries, in the years preceding publication of each progress monitor, mean total policy implementation score (out of a potential 18\u00b70) was 7\u00b70 (SD 3\u00b75) in 2014, 8\u00b72 (3\u00b75) in 2016, 8\u00b76 (3\u00b76) in 2019, and 8\u00b76 (3\u00b76) in 2021. Only the differences in mean implementation score between 2014 and the other three report years were deemed statistically significant (pairwise p<0\u00b705). Thus the steady improvement in mean global NCD policy implementation stalled in 2021 at 47\u00b78%. However, from 2019 to 2021, we identified shifts in individual policies: global mean implementation scores increased for policies on tobacco, clinical guidelines, salt, and child food marketing, and decreased for policies on alcohol, breastmilk substitute marketing, physical activity mass media campaigns, risk factor surveys, and national NCD plans and targets. Six of the seven policies with the lowest levels of implementation (global mean score <0\u00b74 out of a potential 1\u00b70) in both 2019 and 2021 were related to tobacco, alcohol, and unhealthy food. From 2020 onwards, we identified weak or no associations between sales of tobacco, alcohol, and junk foods and the predicted probability of implementing policies related to each commodity. Country-level CFII was significantly associated with total policy implementation score (Pearson's r -0\u00b749, 95% CI -0\u00b759 to -0\u00b736), and this finding was supported in multivariate modelling for all policies combined and for all commercial policies except alcohol policies.\n\nNCD policy implementation has stagnated. Progress in the implementation of some policies is matched by decreased implementation of others, particularly those related to unhealthy commodities. To prevent NCDs and their consequences, and attain the Sustainable Development Goals, the rate of NCD policy adoption must be substantially and urgently increased before the next NCD progress monitor and UN high-level meeting on NCDs in 2024.\n\nNone.", "doi": "10.1016/S2214-109X(23)00042-6", "pmid": "36925173", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2214-109X(23)00042-6"}], "notes": [], "created": "2023-04-21T16:12:27.828Z", "modified": "2023-04-21T16:12:27.845Z"}, {"entity": "publication", "iuid": "c06838cf20b24f98b0b4adb60797e096", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c06838cf20b24f98b0b4adb60797e096.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c06838cf20b24f98b0b4adb60797e096"}}, "title": "Nirmatrelvir/ritonavir in COVID-19 patients with haematological malignancies: a report from the EPICOVIDEHA registry.", "authors": [{"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J"}, {"family": "Marchesi", "given": "Francesco", "initials": "F"}, {"family": "Gomes da Silva", "given": "Maria", "initials": "M"}, {"family": "Farina", "given": "Francesca", "initials": "F"}, {"family": "D\u00e1vila-Valls", "given": "Julio", "initials": "J"}, {"family": "Bilgin", "given": "Yavuz M", "initials": "YM"}, {"family": "Glenth\u00f8j", "given": "Andreas", "initials": "A"}, {"family": "Falces-Romero", "given": "Iker", "initials": "I"}, {"family": "Van Doesum", "given": "Jaap", "initials": "J"}, {"family": "Labrador", "given": "Jorge", "initials": "J"}, {"family": "Buquicchio", "given": "Caterina", "initials": "C"}, {"family": "El-Ashwah", "given": "Shaimaa", "initials": "S"}, {"family": "Petzer", "given": "Verena", "initials": "V"}, {"family": "Van Praet", "given": "Jens", "initials": "J"}, {"family": "Sch\u00f6nlein", "given": "Martin", "initials": "M"}, {"family": "Dargenio", "given": "Michelina", "initials": "M"}, {"family": "M\u00e9ndez", "given": "Gustavo-Adolfo", "initials": "GA"}, {"family": "Meers", "given": "Stef", "initials": "S"}, {"family": "Itri", "given": "Federico", "initials": "F"}, {"family": "Giordano", "given": "Antonio", "initials": "A"}, {"family": "Pincz\u00e9s", "given": "L\u00e1szl\u00f3 Imre", "initials": "LI"}, {"family": "Espigado", "given": "Ildefonso", "initials": "I"}, {"family": "Stojanoski", "given": "Zlate", "initials": "Z"}, {"family": "L\u00f3pez-Garc\u00eda", "given": "Alberto", "initials": "A"}, {"family": "Prezioso", "given": "Lucia", "initials": "L"}, {"family": "Jaksic", "given": "Ozren", "initials": "O"}, {"family": "Vena", "given": "Antonio", "initials": "A"}, {"family": "Fracchiolla", "given": "Nicola S", "initials": "NS"}, {"family": "Gonz\u00e1lez-L\u00f3pez", "given": "Tom\u00e1s Jos\u00e9", "initials": "TJ"}, {"family": "Colovi\u0107", "given": "Natasa", "initials": "N"}, {"family": "Delia", "given": "Mario", "initials": "M"}, {"family": "Weinbergerov\u00e1", "given": "Barbora", "initials": "B"}, {"family": "Marchetti", "given": "Monia", "initials": "M"}, {"family": "Marques de Almeida", "given": "Joyce", "initials": "J"}, {"family": "Finizio", "given": "Olimpia", "initials": "O"}, {"family": "Besson", "given": "Caroline", "initials": "C"}, {"family": "Biernat", "given": "Monika M", "initials": "MM"}, {"family": "Valkovi\u0107", "given": "Toni", "initials": "T"}, {"family": "Lahmer", "given": "Tobias", "initials": "T"}, {"family": "Cuccaro", "given": "Annarosa", "initials": "A"}, {"family": "Ormazabal-V\u00e9lez", "given": "Irati", "initials": "I"}, {"family": "Batini\u0107", "given": "Josip", "initials": "J"}, {"family": "Fern\u00e1ndez", "given": "Noem\u00ed", "initials": "N"}, {"family": "De Jonge", "given": "Nick", "initials": "N"}, {"family": "Tascini", "given": "Carlo", "initials": "C"}, {"family": "Anastasopoulou", "given": "Amalia N", "initials": "AN"}, {"family": "Dul\u00e9ry", "given": "R\u00e9my", "initials": "R"}, {"family": "Del Principe", "given": "Maria Ilaria", "initials": "MI"}, {"family": "Plantefeve", "given": "Ga\u00ebtan", "initials": "G"}, {"family": "Papa", "given": "Mario Virgilio", "initials": "MV"}, {"family": "Nucci", "given": "Marcio", "initials": "M"}, {"family": "Jim\u00e9nez", "given": "Moraima", "initials": "M"}, {"family": "Aujayeb", "given": "Avinash", "initials": "A"}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jos\u00e9-\u00c1ngel", "initials": "J\u00c1"}, {"family": "Merelli", "given": "Maria", "initials": "M"}, {"family": "Cattaneo", "given": "Chiara", "initials": "C"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Cabirta", "given": "Alba", "initials": "A"}, {"family": "Varricchio", "given": "Gina", "initials": "G"}, {"family": "Sacchi", "given": "Maria Vittoria", "initials": "MV"}, {"family": "Cordoba", "given": "Raul", "initials": "R"}, {"family": "Arellano", "given": "Elena", "initials": "E"}, {"family": "Gr\u00e4fe", "given": "Stefanie K", "initials": "SK"}, {"family": "Wolf", "given": "Dominik", "initials": "D"}, {"family": "Emarah", "given": "Ziad", "initials": "Z"}, {"family": "Ammatuna", "given": "Emanuele", "initials": "E"}, {"family": "Hersby", "given": "Ditte Stampe", "initials": "DS"}, {"family": "Mart\u00edn-P\u00e9rez", "given": "Sonia", "initials": "S"}, {"family": "Nunes Rodrigues", "given": "Raquel", "initials": "R"}, {"family": "Rahimli", "given": "Laman", "initials": "L"}, {"family": "Pagano", "given": "Livio", "initials": "L"}, {"family": "Cornely", "given": "Oliver A", "initials": "OA"}, {"family": "EPICOVIDEHA registry", "given": "", "initials": ""}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": "58", "pages": "101939", "issn-l": null}, "abstract": "Nirmatrelvir/ritonavir treatment decreases the hospitalisation rate in immunocompetent patients with COVID-19, but data on efficacy in patients with haematological malignancy are scarce. Here, we describe the outcome of nirmatrelvir/ritonavir treatment in a large cohort of the latter patients.\n\nThis is a retrospective cohort study from the multicentre EPICOVIDEHA registry (NCT04733729) on patients with haematological malignancy, who were diagnosed with COVID-19 between January and September 2022. Patients receiving nirmatrelvir/ritonavir were compared to those who did not. A logistic regression was run to determine factors associated with nirmatrelvir/ritonavir administration in our sample. Mortality between treatment groups was assessed with Kaplan-Meier survival plots after matching all the patients with a propensity score. Additionally, a Cox regression was modelled to detect factors associated with mortality in patients receiving nirmatrelvir/ritonavir.\n\nA total of 1859 patients were analysed, 117 (6%) were treated with nirmatrelvir/ritonavir, 1742 (94%) were treated otherwise. Of 117 patients receiving nirmatrelvir/ritonavir, 80% had received \u22651 anti-SARS-CoV-2 vaccine dose before COVID-19 onset, 13% of which received a 2nd vaccine booster. 5% were admitted to ICU. Nirmatrelvir/ritonavir treatment was associated with the presence of extrapulmonary symptoms at COVID-19 onset, for example anosmia, fever, rhinitis, or sinusitis (aOR 2.509, 95%CI 1.448-4.347) and 2nd vaccine booster (aOR 3.624, 95%CI 1.619-8.109). Chronic pulmonary disease (aOR 0.261, 95%CI 0.093-0.732) and obesity (aOR 0.105, 95%CI 0.014-0.776) were not associated with nirmatrelvir/ritonavir use. After propensity score matching, day-30 mortality rate in patients treated with nirmatrelvir/ritonavir was 2%, significantly lower than in patients with SARS-CoV-2 directed treatment other than nirmatrelvir/ritonavir (11%, p = 0.036). No factor was observed explaining the mortality difference in patients after nirmatrelvir/ritonavir administration.\n\nHaematological malignancy patients were more likely to receive nirmatrelvir/ritonavir when reporting extrapulmonary symptoms or 2nd vaccine booster at COVID-19 onset, as opposed to chronic pulmonary disease and obesity. The mortality rate in patients treated with nirmatrelvir/ritonavir was lower than in patients with targeted drugs other than nirmatrelvir/ritonavir.\n\nEPICOVIDEHA has received funds from Optics COMMIT (COVID-19 Unmet Medical Needs and Associated Research Extension) COVID-19 RFP program by GILEAD Science, United States (Project 2020-8223).", "doi": "10.1016/j.eclinm.2023.101939", "pmid": "37041967", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC10078172"}, {"db": "pii", "key": "S2589-5370(23)00116-5"}], "notes": [], "created": "2023-04-20T17:27:35.535Z", "modified": "2023-04-20T17:27:35.548Z"}, {"entity": "publication", "iuid": "ddb832068b7446a09e1cbe96bdfe296d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ddb832068b7446a09e1cbe96bdfe296d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ddb832068b7446a09e1cbe96bdfe296d"}}, "title": "New perspectives on respiratory syncytial virus surveillance at the national level: lessons from the COVID-19 pandemic.", "authors": [{"family": "Teirlinck", "given": "Anne C", "initials": "AC", "orcid": "0000-0002-1172-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e135044218dd473e93ce8aa1af84bfde.json"}}, {"family": "Johannesen", "given": "Caroline K", "initials": "CK"}, {"family": "Broberg", "given": "Eeva K", "initials": "EK"}, {"family": "Penttinen", "given": "Pasi", "initials": "P", "orcid": "0000-0001-6929-1086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b71cf06d6ef4127b7816b76ab9b7bf0.json"}}, {"family": "Campbell", "given": "Harry", "initials": "H"}, {"family": "Nair", "given": "Harish", "initials": "H"}, {"family": "Reeves", "given": "Rachel M", "initials": "RM", "orcid": "0000-0002-8949-1568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8dd33b5dce254580806961ea8168490a.json"}}, {"family": "B\u00f8\u00e5s", "given": "H\u00e5kon", "initials": "H", "orcid": "0000-0002-5917-1563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9cc00f104cd64e53ab58eebd46368861.json"}}, {"family": "Brytting", "given": "Mia", "initials": "M"}, {"family": "Cai", "given": "Wei", "initials": "W"}, {"family": "Carnahan", "given": "AnnaSara", "initials": "A"}, {"family": "Casalegno", "given": "Jean-Sebastien", "initials": "JS"}, {"family": "Danis", "given": "Kostas", "initials": "K", "orcid": "0000-0001-6727-7344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19a6a9cd4dc74ca19c47878e93daa5ef.json"}}, {"family": "De Gascun", "given": "Cillian", "initials": "C"}, {"family": "Ellis", "given": "Joanna", "initials": "J"}, {"family": "Emborg", "given": "Hanne-Dorthe", "initials": "HD"}, {"family": "Gijon", "given": "Manuel", "initials": "M"}, {"family": "Guiomar", "given": "Raquel", "initials": "R"}, {"family": "Hirve", "given": "Siddhivinayak S", "initials": "SS"}, {"family": "Ji\u0159incov\u00e1", "given": "Helena", "initials": "H"}, {"family": "Nohynek", "given": "Hanna", "initials": "H"}, {"family": "Oliva", "given": "Jesus Angel", "initials": "JA", "orcid": "0000-0003-4080-7864", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6aab0b9fa36a4c88ac2e9714d3adacdf.json"}}, {"family": "Osei-Yeboah", "given": "Richard", "initials": "R", "orcid": "0000-0003-4622-3691", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14dca19cd0d84d8299341d3eb1357608.json"}}, {"family": "Paget", "given": "John", "initials": "J"}, {"family": "Pakarna", "given": "Gatis", "initials": "G"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "Presser", "given": "Lance", "initials": "L"}, {"family": "Rapp", "given": "Marie", "initials": "M"}, {"family": "Reiche", "given": "Janine", "initials": "J"}, {"family": "Rodrigues", "given": "Ana Paula", "initials": "AP"}, {"family": "Sepp\u00e4l\u00e4", "given": "Elina", "initials": "E"}, {"family": "Socan", "given": "Maja", "initials": "M"}, {"family": "Szymanski", "given": "Karol", "initials": "K", "orcid": "0000-0003-3269-0774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0811c53f65a34c4285dc00e449c16033.json"}}, {"family": "Trebbien", "given": "Ramona", "initials": "R"}, {"family": "Ve\u010de\u0159ov\u00e1", "given": "Jarom\u00edra", "initials": "J"}, {"family": "van der Werf", "given": "Sylvie", "initials": "S", "orcid": "0000-0002-1148-4456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/610e999fc3fa4d24aceecf5a13122ecf.json"}}, {"family": "Zambon", "given": "Maria", "initials": "M"}, {"family": "Meijer", "given": "Adam", "initials": "A", "orcid": "0000-0001-8074-7582", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa6d8f61c7ca4618a4b00d12144bac2d.json"}}, {"family": "Fischer", "given": "Thea K", "initials": "TK"}], "type": "editorial", "published": "2023-04-00", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "volume": "61", "issue": "4", "issn-l": "0903-1936"}, "abstract": "Learning from the COVID-19 pandemic and considering the effects of this pandemic, we provide recommendations that can guide towards sustainable RSV surveillance with the potential to be integrated into the broader perspective of respiratory surveillance. https://bit.ly/40TsO0G", "doi": "10.1183/13993003.01569-2022", "pmid": "37012081", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10069872"}, {"db": "pii", "key": "61/4/2201569"}], "notes": [], "created": "2023-04-20T17:35:20.998Z", "modified": "2023-04-20T17:39:19.993Z"}, {"entity": "publication", "iuid": "6fba8541d13c406298fc41acd760220c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6fba8541d13c406298fc41acd760220c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6fba8541d13c406298fc41acd760220c"}}, "title": "Emergence and antibody evasion of BQ, BA.2.75 and SARS-CoV-2 recombinant sub-lineages in the face of maturing antibody breadth at the population level.", "authors": [{"family": "Akerman", "given": "Anouschka", "initials": "A"}, {"family": "Milogiannakis", "given": "Vanessa", "initials": "V"}, {"family": "Jean", "given": "Tyra", "initials": "T"}, {"family": "Esneau", "given": "Camille", "initials": "C"}, {"family": "Silva", "given": "Mariana Ruiz", "initials": "MR"}, {"family": "Ison", "given": "Timothy", "initials": "T"}, {"family": "Fichter", "given": "Christina", "initials": "C"}, {"family": "Lopez", "given": "Joseph A", "initials": "JA"}, {"family": "Chandra", "given": "Deborah", "initials": "D"}, {"family": "Naing", "given": "Zin", "initials": "Z"}, {"family": "Caguicla", "given": "Joanna", "initials": "J"}, {"family": "Li", "given": "Daiyang", "initials": "D"}, {"family": "Walker", "given": "Gregory", "initials": "G"}, {"family": "Amatayakul-Chantler", "given": "Supavadee", "initials": "S"}, {"family": "Roth", "given": "Nathan", "initials": "N"}, {"family": "Manni", "given": "Sandro", "initials": "S"}, {"family": "Hauser", "given": "Thomas", "initials": "T"}, {"family": "Barnes", "given": "Thomas", "initials": "T"}, {"family": "Condylios", "given": "Anna", "initials": "A"}, {"family": "Yeang", "given": "Malinna", "initials": "M"}, {"family": "Wong", "given": "Maureen", "initials": "M"}, {"family": "Foster", "given": "Charles S P", "initials": "CSP"}, {"family": "Sato", "given": "Kenta", "initials": "K"}, {"family": "Lee", "given": "Sharon", "initials": "S"}, {"family": "Song", "given": "Yang", "initials": "Y"}, {"family": "Mao", "given": "Lijun", "initials": "L"}, {"family": "Sigmund", "given": "Allison", "initials": "A"}, {"family": "Phu", "given": "Amy", "initials": "A"}, {"family": "Vande More", "given": "Ann Marie", "initials": "AM"}, {"family": "Hunt", "given": "Stephanie", "initials": "S"}, {"family": "Douglas", "given": "Mark", "initials": "M"}, {"family": "Caterson", "given": "Ian", "initials": "I"}, {"family": "Britton", "given": "Warwick", "initials": "W"}, {"family": "Sandgren", "given": "Kerrie", "initials": "K"}, {"family": "Bull", "given": "Rowena", "initials": "R"}, {"family": "Lloyd", "given": "Andrew", "initials": "A"}, {"family": "Triccas", "given": "Jamie", "initials": "J"}, {"family": "Tangye", "given": "Stuart", "initials": "S"}, {"family": "Bartlett", "given": "Nathan W", "initials": "NW"}, {"family": "Darley", "given": "David", "initials": "D"}, {"family": "Matthews", "given": "Gail", "initials": "G"}, {"family": "Stark", "given": "Damien J", "initials": "DJ"}, {"family": "Petoumenos", "given": "Kathy", "initials": "K"}, {"family": "Rawlinson", "given": "William D", "initials": "WD"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Brilot", "given": "Fabienne", "initials": "F"}, {"family": "Cunningham", "given": "Anthony L", "initials": "AL"}, {"family": "Kelleher", "given": "Anthony D", "initials": "AD"}, {"family": "Aggarwal", "given": "Anupriya", "initials": "A"}, {"family": "Turville", "given": "Stuart G", "initials": "SG"}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "volume": "90", "pages": "104545", "issn-l": null}, "abstract": "The Omicron era of the COVID-19 pandemic commenced at the beginning of 2022 and whilst it started with primarily BA.1, it was latter dominated by BA.2 and the related sub-lineage BA.5. Following resolution of the global BA.5 wave, a diverse grouping of Omicron sub-lineages emerged derived from BA.2, BA.5 and recombinants thereof. Whilst emerging from distinct lineages, all shared similar changes in the Spike glycoprotein affording them an outgrowth advantage through evasion of neutralising antibodies.\n\nOver the course of 2022, we monitored the potency and breadth of antibody neutralization responses to many emerging variants in the Australian community at three levels: (i) we tracked over 420,000 U.S. plasma donors over time through various vaccine booster roll outs and Omicron waves using sequentially collected IgG pools; (ii) we mapped the antibody response in individuals using blood from stringently curated vaccine and convalescent cohorts. (iii) finally we determine the in vitro efficacy of clinically approved therapies Evusheld and Sotrovimab.\n\nIn pooled IgG samples, we observed the maturation of neutralization breadth to Omicron variants over time through continuing vaccine and infection waves. Importantly, in many cases, we observed increased antibody breadth to variants that were yet to be in circulation. Determination of viral neutralization at the cohort level supported equivalent coverage across prior and emerging variants with isolates BQ.1.1, XBB.1, BR.2.1 and XBF the most evasive. Further, these emerging variants were resistant to Evusheld, whilst increasing neutralization resistance to Sotrovimab was restricted to BQ.1.1 and XBF. We conclude at this current point in time that dominant variants can evade antibodies at levels equivalent to their most evasive lineage counterparts but sustain an entry phenotype that continues to promote an additional outgrowth advantage. In Australia, BR.2.1 and XBF share this phenotype and, in contrast to global variants, are uniquely dominant in this region in the later months of 2022.\n\nWhilst the appearance of a diverse range of omicron lineages has led to primary or partial resistance to clinically approved monoclonal antibodies, the maturation of the antibody response across both cohorts and a large donor pools importantly observes increasing breadth in the antibody neutralisation responses over time with a trajectory that covers both current and known emerging variants.\n\nThis work was primarily supported by Australian Medical Foundation research grants MRF2005760 (SGT, GM & WDR), Medical Research Future Fund Antiviral Development Call grant (WDR), the New South Wales Health COVID-19 Research Grants Round 2 (SGT & FB) and the NSW Vaccine Infection and Immunology Collaborative (VIIM) (ALC). Variant modeling was supported by funding from SciLifeLab's Pandemic Laboratory Preparedness program to B.M. (VC-2022-0028) and by the European Union's Horizon 2020 research and innovation programme under grant agreement no. 101003653 (CoroNAb) to B.M.", "doi": "10.1016/j.ebiom.2023.104545", "pmid": "37002990", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10060887"}, {"db": "pii", "key": "S2352-3964(23)00110-X"}], "notes": [], "created": "2023-04-20T17:41:13.979Z", "modified": "2023-04-20T17:41:13.982Z"}, {"entity": "publication", "iuid": "04186ca4c37344d585b7d735b4454a72", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/04186ca4c37344d585b7d735b4454a72.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/04186ca4c37344d585b7d735b4454a72"}}, "title": "Contextualising adverse events of special interest to characterise the baseline incidence rates in 24 million patients with COVID-19 across 26 databases: a multinational retrospective cohort study.", "authors": [{"family": "Voss", "given": "Erica A", "initials": "EA"}, {"family": "Shoaibi", "given": "Azza", "initials": "A"}, {"family": "Yin Hui Lai", "given": "Lana", "initials": "L"}, {"family": "Blacketer", "given": "Clair", "initials": "C"}, {"family": "Alshammari", "given": "Thamir", "initials": "T"}, {"family": "Makadia", "given": "Rupa", "initials": "R"}, {"family": "Haynes", "given": "Kevin", "initials": "K"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Rao", "given": "Gowtham", "initials": "G"}, {"family": "van Sandijk", "given": "Sebastiaan", "initials": "S"}, {"family": "Fraboulet", "given": "Clement", "initials": "C"}, {"family": "Boyer", "given": "Laurent", "initials": "L"}, {"family": "Le Carrour", "given": "Tanguy", "initials": "T"}, {"family": "Horban", "given": "Scott", "initials": "S"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Mart\u00ednez Rold\u00e1n", "given": "Jordi", "initials": "J"}, {"family": "Ram\u00edrez-Anguita", "given": "Juan Manuel", "initials": "JM"}, {"family": "Mayer", "given": "Miguel A", "initials": "MA"}, {"family": "de Wilde", "given": "Marcel", "initials": "M"}, {"family": "John", "given": "Luis H", "initials": "LH"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "Roel", "given": "Elena", "initials": "E"}, {"family": "Pistillo", "given": "Andrea", "initials": "A"}, {"family": "Kolde", "given": "Raivo", "initials": "R"}, {"family": "Maljkovi\u0107", "given": "Filip", "initials": "F"}, {"family": "Denaxas", "given": "Spiros", "initials": "S"}, {"family": "Papez", "given": "Vaclav", "initials": "V"}, {"family": "Kahn", "given": "Michael G", "initials": "MG"}, {"family": "Natarajan", "given": "Karthik", "initials": "K"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Secora", "given": "Alex", "initials": "A"}, {"family": "Minty", "given": "Evan P", "initials": "EP"}, {"family": "Shah", "given": "Nigam H", "initials": "NH"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Garcia Morales", "given": "Maria Teresa", "initials": "MT"}, {"family": "Bosca", "given": "Diego", "initials": "D"}, {"family": "Cadenas Juanino", "given": "Honorio", "initials": "H"}, {"family": "Diaz Holgado", "given": "Antonio", "initials": "A"}, {"family": "Pedrera Jim\u00e9nez", "given": "Miguel", "initials": "M"}, {"family": "Serrano Balazote", "given": "Pablo", "initials": "P"}, {"family": "Garc\u00eda Barrio", "given": "Noelia", "initials": "N"}, {"family": "\u015een", "given": "Sel\u00e7uk", "initials": "S"}, {"family": "\u00dcresin", "given": "Ali Ya\u011f\u0131z", "initials": "AY"}, {"family": "Erdogan", "given": "Baris", "initials": "B"}, {"family": "Belmans", "given": "Luc", "initials": "L"}, {"family": "Byttebier", "given": "Geert", "initials": "G"}, {"family": "Malbrain", "given": "Manu L N G", "initials": "MLNG"}, {"family": "Dedman", "given": "Daniel J", "initials": "DJ"}, {"family": "Cuccu", "given": "Zara", "initials": "Z"}, {"family": "Vashisht", "given": "Rohit", "initials": "R"}, {"family": "Butte", "given": "Atul J", "initials": "AJ"}, {"family": "Patel", "given": "Ayan", "initials": "A"}, {"family": "Dahm", "given": "Lisa", "initials": "L"}, {"family": "Han", "given": "Cora", "initials": "C"}, {"family": "Bu", "given": "Fan", "initials": "F"}, {"family": "Arshad", "given": "Faaizah", "initials": "F"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Prieto-Alhambra", "given": "Dani", "initials": "D"}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR"}, {"family": "Schuemie", "given": "Martijn J", "initials": "MJ"}, {"family": "Ryan", "given": "Patrick B", "initials": "PB"}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": "58", "pages": "101932", "issn-l": null}, "abstract": "Adverse events of special interest (AESIs) were pre-specified to be monitored for the COVID-19 vaccines. Some AESIs are not only associated with the vaccines, but with COVID-19. Our aim was to characterise the incidence rates of AESIs following SARS-CoV-2 infection in patients and compare these to historical rates in the general population.\n\nA multi-national cohort study with data from primary care, electronic health records, and insurance claims mapped to a common data model. This study's evidence was collected between Jan 1, 2017 and the conclusion of each database (which ranged from Jul 2020 to May 2022). The 16 pre-specified prevalent AESIs were: acute myocardial infarction, anaphylaxis, appendicitis, Bell's palsy, deep vein thrombosis, disseminated intravascular coagulation, encephalomyelitis, Guillain- Barr\u00e9 syndrome, haemorrhagic stroke, non-haemorrhagic stroke, immune thrombocytopenia, myocarditis/pericarditis, narcolepsy, pulmonary embolism, transverse myelitis, and thrombosis with thrombocytopenia. Age-sex standardised incidence rate ratios (SIR) were estimated to compare post-COVID-19 to pre-pandemic rates in each of the databases.\n\nSubstantial heterogeneity by age was seen for AESI rates, with some clearly increasing with age but others following the opposite trend. Similarly, differences were also observed across databases for same health outcome and age-sex strata. All studied AESIs appeared consistently more common in the post-COVID-19 compared to the historical cohorts, with related meta-analytic SIRs ranging from 1.32 (1.05 to 1.66) for narcolepsy to 11.70 (10.10 to 13.70) for pulmonary embolism.\n\nOur findings suggest all AESIs are more common after COVID-19 than in the general population. Thromboembolic events were particularly common, and over 10-fold more so. More research is needed to contextualise post-COVID-19 complications in the longer term.\n\nNone.", "doi": "10.1016/j.eclinm.2023.101932", "pmid": "37034358", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10072853"}, {"db": "pii", "key": "S2589-5370(23)00109-8"}], "notes": [], "created": "2023-04-20T17:29:48.848Z", "modified": "2023-04-20T17:29:48.862Z"}, {"entity": "publication", "iuid": "02795f7098f24bff96850deb84f65aac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02795f7098f24bff96850deb84f65aac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02795f7098f24bff96850deb84f65aac"}}, "title": "Changes in sexual activities, function, and satisfaction during the COVID-19 pandemic era: a systematic review and meta-analysis.", "authors": [{"family": "Qaderi", "given": "Kowsar", "initials": "K"}, {"family": "Yazdkhasti", "given": "Mansoureh", "initials": "M"}, {"family": "Zangeneh", "given": "Sanaz", "initials": "S"}, {"family": "Behbahani", "given": "Bahar Morshed", "initials": "BM"}, {"family": "Kalhor", "given": "Mehri", "initials": "M"}, {"family": "Shamsabadi", "given": "Ahmadreza", "initials": "A"}, {"family": "Jesmani", "given": "Younes", "initials": "Y"}, {"family": "Norouzi", "given": "Solmaz", "initials": "S"}, {"family": "Kajbafvala", "given": "Mehrnaz", "initials": "M"}, {"family": "Khodavirdilou", "given": "Rasa", "initials": "R"}, {"family": "Rahmani", "given": "Nahid", "initials": "N"}, {"family": "Namadian", "given": "Masoumeh", "initials": "M"}, {"family": "Ezabadi", "given": "Sajjad Ghane", "initials": "SG"}, {"family": "Alkatout", "given": "Ibrahim", "initials": "I"}, {"family": "Mehraeen", "given": "Esmaeel", "initials": "E"}, {"family": "Rasoal", "given": "Dara", "initials": "D"}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "Sex Med", "issn": "2050-1161", "volume": "11", "issue": "2", "pages": "qfad005", "issn-l": null}, "abstract": "Little is known about the impact of the coronavirus on sexual behavior, function, and satisfaction.\n\nThe aim of the present study was to systematically review people's sexual function and behaviors and their changes in sexual activities during the COVID-19 pandemic.\n\nComprehensive searches in PubMed, Web of Science, and Scopus were conducted with keywords in accordance with MeSH terms: COVID-19, SARS-CoV-2, coronavirus, sexual health, sexual function, sexual dysfunctions, sexuality, sexual orientation, sexual activities, and premarital sex. Two reviewers independently assessed full-text articles according to predefined criteria: original design, English studies, and investigating either the general population or sexual minorities.\n\nRisk of bias in the studies was assessed by the Newcastle-Ottawa Scale, and data were pooled via random effects meta-analyses. We utilized the standardized mean difference to evaluate the effects of the COVID-19 pandemic on sexual activity, functioning, and satisfaction. We included 19 studies in the analysis and 11 studies in the meta-analysis, with a sample size of 12 350. To investigate sexual activity changes, a sample size of 8838 was entered into the subgroup analysis, which showed a significant decrease in both genders (5821 women, P < .033; 3017 men, P < .008). A subgroup meta-analysis showed that the sexual function of men and women during the COVID-19 pandemic significantly declined (3974 women, P < .001; 1427 men, P < .001). Sexual desire and arousal decreased in both genders, though mainly in women. In investigating sexual satisfaction changes during the COVID-19 pandemic, a meta-analysis with a sample size of 2711 showed a significant decrease (P < .001). The most indicative changes in sexual behaviors during the pandemic were the increase in masturbating and usage of sex toys. Greater COVID-19 knowledge was associated with lower masturbation, oral sex, and vaginal sex. The more protective behaviors were associated with less hugging, kissing, cuddling, genital touching, watching porn with a partner, and vaginal sex.\n\nThe COVID-19 pandemic led to increased challenges and changes for individuals' sexual behaviors. Efforts for preventive strategies should therefore be concentrated between pandemics, while ensuring that there is information available to the population during a pandemic for help in times of psychological distress or crisis.", "doi": "10.1093/sexmed/qfad005", "pmid": "36970584", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10037164"}, {"db": "pii", "key": "qfad005"}], "notes": [], "created": "2023-04-21T16:00:18.555Z", "modified": "2023-04-21T16:00:42.709Z"}, {"entity": "publication", "iuid": "9187c61acefa4eae9abaaebe2dbac652", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9187c61acefa4eae9abaaebe2dbac652.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9187c61acefa4eae9abaaebe2dbac652"}}, "title": "An XAI approach for COVID-19 detection using transfer learning with X-ray images.", "authors": [{"family": "Sarp", "given": "Salih", "initials": "S"}, {"family": "Catak", "given": "Ferhat Ozgur", "initials": "FO"}, {"family": "Kuzlu", "given": "Murat", "initials": "M"}, {"family": "Cali", "given": "Umit", "initials": "U"}, {"family": "Kusetogullari", "given": "Huseyin", "initials": "H"}, {"family": "Zhao", "given": "Yanxiao", "initials": "Y"}, {"family": "Ates", "given": "Gungor", "initials": "G"}, {"family": "Guler", "given": "Ozgur", "initials": "O"}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": "9", "issue": "4", "pages": "e15137", "issn-l": null}, "abstract": "The coronavirus disease (COVID-19) has continued to cause severe challenges during this unprecedented time, affecting every part of daily life in terms of health, economics, and social development. There is an increasing demand for chest X-ray (CXR) scans, as pneumonia is the primary and vital complication of COVID-19. CXR is widely used as a screening tool for lung-related diseases due to its simple and relatively inexpensive application. However, these scans require expert radiologists to interpret the results for clinical decisions, i.e., diagnosis, treatment, and prognosis. The digitalization of various sectors, including healthcare, has accelerated during the pandemic, with the use and importance of Artificial Intelligence (AI) dramatically increasing. This paper proposes a model using an Explainable Artificial Intelligence (XAI) technique to detect and interpret COVID-19 positive CXR images. We further analyze the impact of COVID-19 positive CXR images using heatmaps. The proposed model leverages transfer learning and data augmentation techniques for faster and more adequate model training. Lung segmentation is applied to enhance the model performance further. We conducted a pre-trained network comparison with the highest classification performance (F1-Score: 98%) using the ResNet model.", "doi": "10.1016/j.heliyon.2023.e15137", "pmid": "37041935", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10080863"}, {"db": "pii", "key": "S2405-8440(23)02344-7"}], "notes": [], "created": "2023-04-20T17:27:55.201Z", "modified": "2023-04-20T17:28:06.103Z"}, {"entity": "publication", "iuid": "69c29e2854784570bf943d9f060510a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69c29e2854784570bf943d9f060510a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69c29e2854784570bf943d9f060510a6"}}, "title": "Systemic sclerosis and COVID-19 vaccine safety: short-term insights from the global COVID-19 vaccination in autoimmune disease (COVAD) survey.", "authors": [{"family": "Naveen", "given": "R", "initials": "R", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Thakare", "given": "Darpan R", "initials": "DR", "orcid": "0000-0002-6852-4869", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b89611ef037490fb80a852b74f67752.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Pauling", "given": "John D", "initials": "JD", "orcid": "0000-0002-2793-2364", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e37709273d404d17a88c7c850777b99f.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Jagtap", "given": "Kshitij", "initials": "K", "orcid": "0000-0003-2729-737X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822b9da98e5d4eb2975ff97fe484933f.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Saha", "given": "Sreoshy", "initials": "S", "orcid": "0000-0001-6745-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00238845dd4833ae51ffb75e2fe144.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Kardes", "given": "Sinan", "initials": "S", "orcid": "0000-0002-6311-8634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2900c3ca00da476a8914574384a3c9c2.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "COVAD Study Group", "given": "", "initials": ""}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}], "type": "journal article", "published": "2023-03-31", "journal": {"title": "Rheumatol Int", "issn": "1437-160X", "pages": "1-11", "issn-l": null}, "abstract": "The safety profile of COVID-19 vaccines is understudied in patients with systemic sclerosis (SSc). We compared short-term adverse events (AEs) 7 days following vaccination in patients with SSc vs other rheumatic (AIRDs), non-rheumatic autoimmune diseases (nrAIDs), and healthy controls (HCs). The COVID-19 Vaccination in autoimmune diseases (COVAD) self-reporting e-survey was circulated by a group of > 110 collaborators in 94 countries from March to December 2021. AEs were analyzed between different groups using regression models. Of 10,679 complete respondents [73.8% females, mean age 43 years, 53% Caucasians], 478 had SSc. 83% had completed two vaccine doses, Pfizer-BioNTech (BNT162b2) (51%) was the most common. Minor and major AEs were reported by 81.2% and 3.3% SSc patients, respectively, and did not differ significantly with disease activity or different vaccine types, though with minor symptom differences. Frequencies of AEs were not affected by background immunosuppression, though SSc patients receiving hydroxychloroquine experienced fatigue less commonly (OR 0.4; 95% CI 0.2-0.8). Frequency of AEs and hospitalisations were similar to other AIRDs, nrAIDs, and HC except a higher risk of chills (OR 1.3; 95% CI 1.0-1.7) and fatigue (OR 1.3; 95% CI 1.0-1.6) compared to other AIRDs. COVID-19 vaccines were largely safe and well tolerated in SSc patients in the short term. Background immunosuppression and disease activity did not influence the vaccination-related short-term AEs.", "doi": "10.1007/s00296-023-05310-9", "pmid": "37000295", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10064600"}, {"db": "pii", "key": "10.1007/s00296-023-05310-9"}], "notes": [], "created": "2023-04-20T17:42:14.492Z", "modified": "2023-04-20T17:42:21.934Z"}, {"entity": "publication", "iuid": "8a7a4dc6524c476fbdf4224540d925f6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a7a4dc6524c476fbdf4224540d925f6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a7a4dc6524c476fbdf4224540d925f6"}}, "title": "Ionizable lipids penetrate phospholipid bilayers with high phase transition temperatures: perspectives from free energy calculations.", "authors": [{"family": "Ermilova", "given": "Inna", "initials": "I"}, {"family": "Swenson", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2023-03-31", "journal": {"title": "Chem Phys Lipids", "issn": "1873-2941", "volume": "253", "pages": "105294", "issn-l": null}, "abstract": "The efficacies of modern gene-therapies strongly depend on their contents. At the same time the most potent formulations might not contain the best compounds. In this work we investigated the effect of phospholipids and their saturation on the binding ability of (6Z,9Z,28Z,31Z)-heptatriacont-6,9,28,31-tetraene-19-yl 4-(dimethylamino) butanoate (DLin-MC3-DMA) to model membranes at the neutral pH. We discovered that DLin-MC3-DMA has affinity to the most saturated monocomponent lipid bilayer 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and an aversion to the unsaturated one 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC). The preference to a certain membrane was also well-correlated to the phase transition temperatures of phospholipid bilayers, and to their structural and dynamical properties. Additionally, in the case of the presence of DLin-MC3-DMA in the membrane with DOPC the ionizable lipid penetrated it, which indicates possible synergistic effects. Comparisons with other ionizable lipids were performed using a model lipid bilayer of 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine (POPC). Particularly, the lipids heptadecan-9-yl 8-[2-hydroxyethyl-(6-oxo-6-undecoxyhexyl)amino]octanoate (SM-102) and [(4-hydroxybutyl) azanediyl] di(hexane-6,1-diyl) bis(2-hexyldecanoate) (ALC-0315) from modern mRNA-vaccines against COVID-19 were investigated and force fields parameters were derived for those new lipids. It was discovered that ALC-0315 binds strongest to the membrane, while DLin-MC3-DMA is not able to reside in the bilayer center. The ability to penetrate the membrane POPC by SM-102 and ALC-0315 can be related to their saturation, comparing to DLin-MC3-DMA.", "doi": "10.1016/j.chemphyslip.2023.105294", "pmid": "37003484", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0009-3084(23)00016-6"}], "notes": [], "created": "2023-04-20T17:40:26.665Z", "modified": "2023-04-20T17:40:26.698Z"}, {"entity": "publication", "iuid": "f937469419534ab381cfbf50a42f32f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f937469419534ab381cfbf50a42f32f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f937469419534ab381cfbf50a42f32f7"}}, "title": "Addressing global disparities in blood pressure control: perspectives of the International Society of Hypertension.", "authors": [{"family": "Schutte", "given": "Aletta E", "initials": "AE", "orcid": "0000-0001-9217-4937", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/101d8070a2cb43b198f974d3c40eaa4c.json"}}, {"family": "Jafar", "given": "Tazeen H", "initials": "TH", "orcid": "0000-0001-7454-8376", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96c13f8991f54072b38dcf21358e886b.json"}}, {"family": "Poulter", "given": "Neil R", "initials": "NR", "orcid": "0000-0002-6292-997X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4533dad3e82f4033bd1759f6792d60ee.json"}}, {"family": "Damasceno", "given": "Albertino", "initials": "A", "orcid": "0000-0002-5547-0224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2545cf0bbaf46629c6a5b0df1e0a887.json"}}, {"family": "Khan", "given": "Nadia A", "initials": "NA"}, {"family": "Nilsson", "given": "Peter M", "initials": "PM", "orcid": "0000-0002-5652-8459", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24f3c955840443a2a7b61839834ca30c.json"}}, {"family": "Alsaid", "given": "Jafar", "initials": "J", "orcid": "0000-0002-0269-5630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8033a5b1ce92459ea5aac83edc94b770.json"}}, {"family": "Neupane", "given": "Dinesh", "initials": "D", "orcid": "0000-0002-1501-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cdf496b02ca4c75ae012d8b88fd2513.json"}}, {"family": "Kario", "given": "Kazuomi", "initials": "K", "orcid": "0000-0002-8251-4480", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fc9431ed85a4f28a68540e3119e63b9.json"}}, {"family": "Beheiry", "given": "Hind", "initials": "H", "orcid": "0000-0001-6905-1867", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc79ed8474c84e24b20f492877aff5d7.json"}}, {"family": "Brouwers", "given": "Sofie", "initials": "S", "orcid": "0000-0002-7081-4881", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06fb9e105ad242489f5e7d8dda926b6b.json"}}, {"family": "Burger", "given": "Dylan", "initials": "D", "orcid": "0000-0003-3951-2911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6998a09484264b42b22222219cd3dc3c.json"}}, {"family": "Charchar", "given": "Fadi J", "initials": "FJ", "orcid": "0000-0002-6164-9941", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db655f3c3bfa4a95837434be78187209.json"}}, {"family": "Cho", "given": "Myeong-Chan", "initials": "MC", "orcid": "0000-0002-0047-0227", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98ded8bfd8194c809224851131643c43.json"}}, {"family": "Guzik", "given": "Tomasz J", "initials": "TJ", "orcid": "0000-0002-5039-7849", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72f67c1d004e45d294553c8a9dec0545.json"}}, {"family": "Haji Al-Saedi", "given": "Ghazi F", "initials": "GF", "orcid": "0000-0001-5261-3106", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c2adbf00e8f4a178adb1458e3cb30bc.json"}}, {"family": "Ishaq", "given": "Muhammad", "initials": "M", "orcid": "0000-0001-9725-2164", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fadfe352b564e738c49ada92afa5700.json"}}, {"family": "Itoh", "given": "Hiroshi", "initials": "H", "orcid": "0000-0003-2514-4919", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb8fd0d9f90549a182897d73f1cb4216.json"}}, {"family": "Jones", "given": "Erika S W", "initials": "ESW", "orcid": "0000-0002-3569-3498", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62c0de53e979472aaad042d112643338.json"}}, {"family": "Khan", "given": "Taskeen", "initials": "T", "orcid": "0000-0002-1676-4895", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/829167b193864e118e478dca9414f7a8.json"}}, {"family": "Kokubo", "given": "Yoshihiro", "initials": "Y", "orcid": "0000-0002-0705-9449", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79bbc719d1a44d5db033585b9fc784e8.json"}}, {"family": "Kotruchin", "given": "Praew", "initials": "P", "orcid": "0000-0003-3519-3415", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fcfb1decd3bd451eb143bbf48db8eb64.json"}}, {"family": "Muxfeldt", "given": "Elizabeth", "initials": "E", "orcid": "0000-0003-3853-7842", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8338f3cb9cab414fbd89828994fe210c.json"}}, {"family": "Odili", "given": "Augustine", "initials": "A", "orcid": "0000-0002-4564-1587", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dff5dcd1a2604323805b91f403b8a038.json"}}, {"family": "Patil", "given": "Mansi", "initials": "M", "orcid": "0000-0002-2337-385X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03056f2f9f4544fd9f1e5f5570e6f262.json"}}, {"family": "Ralapanawa", "given": "Udaya", "initials": "U", "orcid": "0000-0002-7416-7984", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c87c01d2e0294e7dbbad6f39666e34c5.json"}}, {"family": "Romero", "given": "Cesar A", "initials": "CA", "orcid": "0000-0002-8445-9665", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/391ecd75a1b14398989524d9c016b738.json"}}, {"family": "Schlaich", "given": "Markus P", "initials": "MP", "orcid": "0000-0002-1765-0195", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/861a9872844a48718c4b20613099d65a.json"}}, {"family": "Shehab", "given": "Abdulla", "initials": "A", "orcid": "0000-0001-8533-9174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0448033a990d4e08a2736e4efabf90bc.json"}}, {"family": "Mooi", "given": "Ching Siew", "initials": "CS", "orcid": "0000-0002-4425-7989", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9209d3bf7da445ee9e69147c20860be5.json"}}, {"family": "Steckelings", "given": "U Muscha", "initials": "UM", "orcid": "0000-0002-5430-4275", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea42dcd8ea9b4a2c9b4c80bc46c4bccc.json"}}, {"family": "Stergiou", "given": "George", "initials": "G", "orcid": "0000-0002-6132-0038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87b549c63cfa4e5bb947cd868fc7318a.json"}}, {"family": "Touyz", "given": "Rhian M", "initials": "RM", "orcid": "0000-0003-0670-0887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a382d644347d432bbda6ccb135e91cff.json"}}, {"family": "Unger", "given": "Thomas", "initials": "T", "orcid": "0000-0002-0233-8705", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/afdfe83d52034a7481d6ae01a1afbd3a.json"}}, {"family": "Wainford", "given": "Richard D", "initials": "RD", "orcid": "0000-0003-2830-5618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e88bd9e155244c29985b7d5b7acba15.json"}}, {"family": "Wang", "given": "Ji-Guang", "initials": "JG", "orcid": "0000-0001-8511-1524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eafaab42fae54c97860eadc1f1e5e62b.json"}}, {"family": "Williams", "given": "Bryan", "initials": "B", "orcid": "0000-0002-8094-1841", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5491ff3f5d0245728fb17be9d4265105.json"}}, {"family": "Wynne", "given": "Brandi M", "initials": "BM", "orcid": "0000-0003-0861-4245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d76304dc88d74beb923f4bca698e3926.json"}}, {"family": "Tomaszewski", "given": "Maciej", "initials": "M", "orcid": "0000-0001-8215-6567", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f32a5e3c5d544e9a82fc9cc27bbeb9db.json"}}], "type": "journal article", "published": "2023-03-31", "journal": {"title": "Cardiovasc Res", "issn": "1755-3245", "volume": "119", "issue": "2", "pages": "381-409", "issn-l": null}, "abstract": "Raised blood pressure (BP) is the leading cause of preventable death in the world. Yet, its global prevalence is increasing, and it remains poorly detected, treated, and controlled in both high- and low-resource settings. From the perspective of members of the International Society of Hypertension based in all regions, we reflect on the past, present, and future of hypertension care, highlighting key challenges and opportunities, which are often region-specific. We report that most countries failed to show sufficient improvements in BP control rates over the past three decades, with greater improvements mainly seen in some high-income countries, also reflected in substantial reductions in the burden of cardiovascular disease and deaths. Globally, there are significant inequities and disparities based on resources, sociodemographic environment, and race with subsequent disproportionate hypertension-related outcomes. Additional unique challenges in specific regions include conflict, wars, migration, unemployment, rapid urbanization, extremely limited funding, pollution, COVID-19-related restrictions and inequalities, obesity, and excessive salt and alcohol intake. Immediate action is needed to address suboptimal hypertension care and related disparities on a global scale. We propose a Global Hypertension Care Taskforce including multiple stakeholders and societies to identify and implement actions in reducing inequities, addressing social, commercial, and environmental determinants, and strengthening health systems implement a well-designed customized quality-of-care improvement framework.", "doi": "10.1093/cvr/cvac130", "pmid": "36219457", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9619669"}, {"db": "pii", "key": "6758338"}], "notes": [], "created": "2023-04-12T16:46:53.765Z", "modified": "2023-04-12T16:46:54.891Z"}, {"entity": "publication", "iuid": "22e21e095c774dbaa7909cee0507b0d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/22e21e095c774dbaa7909cee0507b0d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/22e21e095c774dbaa7909cee0507b0d0"}}, "title": "The COPE Staff study: Study description and initial report regarding job satisfaction, work-life conflicts, stress, and burnout among Swedish maternal and neonatal healthcare workers during the COVID-19 pandemic.", "authors": [{"family": "Akerstrom", "given": "Magnus", "initials": "M", "orcid": "0000-0002-8469-6193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89ae0148df6f40cfbd1e490e317f1b03.json"}}, {"family": "Sengpiel", "given": "Verena", "initials": "V", "orcid": "0000-0002-3608-7430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d43b587b94df49f88177d0c804ba7688.json"}}, {"family": "Had\u017eibajramovi\u0107", "given": "Emina", "initials": "E", "orcid": "0000-0002-6630-8898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e56ec24563742ac987a8f5d042a1ade.json"}}, {"family": "Carlsson", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-1414-7279", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2453802e12b43008382f79aebd51ddf.json"}}, {"family": "Graner", "given": "Sofie", "initials": "S", "orcid": "0000-0003-1355-9973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e73c3b5e31c4786b42e33a47db0e82e.json"}}, {"family": "Andersson", "given": "Ola", "initials": "O", "orcid": "0000-0002-3972-0457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77b8a87b252041f094508255b8a43df5.json"}}, {"family": "Jonsson", "given": "Maria", "initials": "M", "orcid": "0000-0002-2657-1958", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ef5424eb68f4181bce3b27c17bbe964.json"}}, {"family": "Naurin", "given": "Elin", "initials": "E", "orcid": "0000-0002-7091-994X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54a0a859d7dc428289d8e60b7e90c125.json"}}, {"family": "Veje", "given": "Malin", "initials": "M", "orcid": "0000-0001-5487-0616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de2e59c2ebcf41759a06fda11b6572bd.json"}}, {"family": "Wessberg", "given": "Anna", "initials": "A", "orcid": "0000-0001-8457-9651", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69ed0ec2bf404955acf6d8735166e6db.json"}}, {"family": "Linden", "given": "Karolina", "initials": "K", "orcid": "0000-0002-2792-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a16575cbdf5a4e0ebab52acaf2404273.json"}}], "type": "journal article", "published": "2023-03-30", "journal": {"title": "Int J Gynaecol Obstet", "issn": "1879-3479", "issn-l": null}, "abstract": "To describe the study design of the COPE Staff cohort study on working conditions for maternal and neonatal healthcare workers (MNHCWs), and present baseline data regarding job satisfaction, work-life conflicts, stress, and burnout.\n\nBetween January and April 2021, 957 MNHCWs (administrative and medical staff) completed a baseline survey. Average levels of job satisfaction, work-life conflicts, stress, and burnout, and associations to perceived workload were assessed.\n\nThe average levels of job satisfaction, work-life conflicts, stress, and burnout were 68.6 (95% confidence interval [CI] 64.3-72.8), 42.6 (95% CI 37.3-48.0), 42.0 (95% CI 37.7-46.3), and 1.9 (95% CI 1.6-2.2), respectively. The respondents scoring above critical values indicating clinical burnout ranged between 3% and 18%, respectively, for the four burnout sub-dimensions. Women reported significantly higher levels of stress and burnout. Younger participants had lower job satisfaction and higher levels of work-life conflicts, stress, and burnout. Higher perceived workload was significantly associated with lower job satisfaction levels and higher levels of work-life conflicts, stress, and burnout.\n\nOur results indicate associations between MNHCWs perceived workload and job satisfaction, work-life conflicts, stress, and burnout during the COVID-19 pandemic. Eighteen percent scored above critical values for exhaustion.", "doi": "10.1002/ijgo.14772", "pmid": "36998146", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-21T15:51:23.619Z", "modified": "2023-04-21T15:51:23.853Z"}, {"entity": "publication", "iuid": "5e1ae5bfc1894e15b2929ce6df1089bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e1ae5bfc1894e15b2929ce6df1089bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e1ae5bfc1894e15b2929ce6df1089bf"}}, "title": "Process development for an effective COVID-19 vaccine candidate harboring recombinant SARS-CoV-2 delta plus receptor binding domain produced by Pichia pastoris.", "authors": [{"family": "Kalyoncu", "given": "Sibel", "initials": "S"}, {"family": "Yilmaz", "given": "Semiramis", "initials": "S"}, {"family": "Kuyucu", "given": "Ayca Zeybek", "initials": "AZ"}, {"family": "Sayili", "given": "Dogu", "initials": "D"}, {"family": "Mert", "given": "Olcay", "initials": "O"}, {"family": "Soyturk", "given": "Hakan", "initials": "H"}, {"family": "Gullu", "given": "Seyda", "initials": "S"}, {"family": "Akinturk", "given": "Huseyin", "initials": "H"}, {"family": "Citak", "given": "Erhan", "initials": "E"}, {"family": "Arslan", "given": "Merve", "initials": "M"}, {"family": "Taskinarda", "given": "Melda Guray", "initials": "MG"}, {"family": "Tarman", "given": "Ibrahim Oguzhan", "initials": "IO"}, {"family": "Altun", "given": "Gizem Yilmazer", "initials": "GY"}, {"family": "Ozer", "given": "Ceren", "initials": "C"}, {"family": "Orkut", "given": "Ridvan", "initials": "R"}, {"family": "Demirtas", "given": "Aysegul", "initials": "A"}, {"family": "Tilmensagir", "given": "Idil", "initials": "I"}, {"family": "Keles", "given": "Umur", "initials": "U"}, {"family": "Ulker", "given": "Ceren", "initials": "C"}, {"family": "Aralan", "given": "Gizem", "initials": "G"}, {"family": "Mercan", "given": "Yavuz", "initials": "Y"}, {"family": "Ozkan", "given": "Muge", "initials": "M"}, {"family": "Caglar", "given": "Hasan Onur", "initials": "HO"}, {"family": "Arik", "given": "Gizem", "initials": "G"}, {"family": "Ucar", "given": "Mehmet Can", "initials": "MC"}, {"family": "Yildirim", "given": "Muzaffer", "initials": "M"}, {"family": "Yildirim", "given": "Tugce Canavar", "initials": "TC"}, {"family": "Karadag", "given": "Dilara", "initials": "D"}, {"family": "Bal", "given": "Erhan", "initials": "E"}, {"family": "Erdogan", "given": "Aybike", "initials": "A"}, {"family": "Senturk", "given": "Serif", "initials": "S"}, {"family": "Uzar", "given": "Serdar", "initials": "S"}, {"family": "Enul", "given": "Hakan", "initials": "H"}, {"family": "Adiay", "given": "Cumhur", "initials": "C"}, {"family": "Sarac", "given": "Fahriye", "initials": "F"}, {"family": "Ekiz", "given": "Arzu Tas", "initials": "AT"}, {"family": "Abaci", "given": "Irem", "initials": "I"}, {"family": "Aksoy", "given": "Ozge", "initials": "O"}, {"family": "Polat", "given": "Hivda Ulbegi", "initials": "HU"}, {"family": "Tekin", "given": "Saban", "initials": "S"}, {"family": "Dimitrov", "given": "Stefan", "initials": "S"}, {"family": "Ozkul", "given": "Aykut", "initials": "A"}, {"family": "Wingender", "given": "Gerhard", "initials": "G"}, {"family": "Gursel", "given": "Ihsan", "initials": "I"}, {"family": "Ozturk", "given": "Mehmet", "initials": "M"}, {"family": "Inan", "given": "Mehmet", "initials": "M"}], "type": "journal article", "published": "2023-03-30", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "13", "issue": "1", "pages": "5224", "issn-l": "2045-2322"}, "abstract": "Recombinant protein-based SARS-CoV-2 vaccines are needed to fill the vaccine equity gap. Because protein-subunit based vaccines are easier and cheaper to produce and do not require special storage/transportation conditions, they are suitable for low-/middle-income countries. Here, we report our vaccine development studies with the receptor binding domain of the SARS-CoV-2 Delta Plus strain (RBD-DP) which caused increased hospitalizations compared to other variants. First, we expressed RBD-DP in the Pichia pastoris yeast system and upscaled it to a 5-L fermenter for production. After three-step purification, we obtained RBD-DP with > 95% purity from a protein yield of > 1 g/L of supernatant. Several biophysical and biochemical characterizations were performed to confirm its identity, stability, and functionality. Then, it was formulated in different contents with Alum and CpG for mice immunization. After three doses of immunization, IgG titers from sera reached to > 106 and most importantly it showed high T-cell responses which are required for an effective vaccine to prevent severe COVID-19 disease. A live neutralization test was performed with both the Wuhan strain (B.1.1.7) and Delta strain (B.1.617.2) and it showed high neutralization antibody content for both strains. A challenge study with SARS-CoV-2 infected K18-hACE2 transgenic mice showed good immunoprotective activity with no viruses in the lungs and no lung inflammation for all immunized mice.", "doi": "10.1038/s41598-023-32021-9", "pmid": "36997624", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10062263"}, {"db": "pii", "key": "10.1038/s41598-023-32021-9"}], "notes": [], "created": "2023-04-21T15:51:40.550Z", "modified": "2023-04-21T15:51:40.564Z"}, {"entity": "publication", "iuid": "3879a05a22354ef2a29861a97ec1b3aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3879a05a22354ef2a29861a97ec1b3aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3879a05a22354ef2a29861a97ec1b3aa"}}, "title": "Long-COVID fatigue is not predicted by pre-pandemic plasma IL-6 levels in mild COVID-19.", "authors": [{"family": "Freidin", "given": "Maxim B", "initials": "MB"}, {"family": "Cheetham", "given": "Nathan", "initials": "N"}, {"family": "Duncan", "given": "Emma L", "initials": "EL"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Doores", "given": "Katherine J", "initials": "KJ"}, {"family": "Malim", "given": "Michael H", "initials": "MH"}, {"family": "Rossi", "given": "Niccolo", "initials": "N"}, {"family": "Lord", "given": "Janet M", "initials": "JM"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Borsini", "given": "Alessandra", "initials": "A"}, {"family": "Granville Smith", "given": "Isabelle", "initials": "I"}, {"family": "Falchi", "given": "Mario", "initials": "M"}, {"family": "Pariante", "given": "Carmine", "initials": "C"}, {"family": "Williams", "given": "Frances M K", "initials": "FMK"}], "type": "journal article", "published": "2023-03-30", "journal": {"title": "Inflamm Res", "issn": "1420-908X", "pages": "1-7", "issn-l": null}, "abstract": "Fatigue is a prominent symptom in the general population and may follow viral infection, including SARS-CoV2 infection which causes COVID-19. Chronic fatigue lasting more than three months is the major symptom of the post-COVID syndrome (known colloquially as long-COVID). The mechanisms underlying long-COVID fatigue are unknown. We hypothesized that the development of long-COVID chronic fatigue is driven by the pro-inflammatory immune status of an individual prior to COVID-19.\n\nWe analyzed pre-pandemic plasma levels of IL-6, which plays a key role in persistent fatigue, in N = 1274 community dwelling adults from TwinsUK. Subsequent COVID-19-positive and -negative participants were categorized based on SARS-CoV-2 antigen and antibody testing. Chronic fatigue was assessed using the Chalder Fatigue Scale.\n\nCOVID-19-positive participants exhibited mild disease. Chronic fatigue was a prevalent symptom among this population and significantly higher in positive vs. negative participants (17% vs 11%, respectively; p = 0.001). The qualitative nature of chronic fatigue as determined by individual questionnaire responses was similar in positive and negative participants. Pre-pandemic plasma IL-6 levels were positively associated with chronic fatigue in negative, but not positive individuals. Raised BMI was associated with chronic fatigue in positive participants.\n\nPre-existing increased IL-6 levels may contribute to chronic fatigue symptoms, but there was no increased risk in individuals with mild COVID-19 compared with uninfected individuals. Elevated BMI also increased the risk of chronic fatigue in mild COVID-19, consistent with previous reports.", "doi": "10.1007/s00011-023-01722-2", "pmid": "36995412", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC10062244"}, {"db": "pii", "key": "10.1007/s00011-023-01722-2"}], "notes": [], "created": "2023-04-21T15:53:33.264Z", "modified": "2023-04-21T15:53:33.267Z"}, {"entity": "publication", "iuid": "0922dd1fd6c24abeab55bc0f7ba26b71", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0922dd1fd6c24abeab55bc0f7ba26b71.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0922dd1fd6c24abeab55bc0f7ba26b71"}}, "title": "Gambling and COVID-19: Swedish national gambling data from a state-owned gambling sports and casino operator.", "authors": [{"family": "Balem", "given": "Marianne", "initials": "M", "orcid": "0000-0002-0324-9579", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0413ef1f13d641c98a0de555c4aad642.json"}}, {"family": "Karlsson", "given": "Anna", "initials": "A", "orcid": "0000-0003-1131-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64c210d9f92940ca9860021e69e56a0b.json"}}, {"family": "Widinghoff", "given": "Carolina", "initials": "C", "orcid": "0000-0002-7810-7065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0a6a5a969444d7b8d27a30090c3216e.json"}}, {"family": "Perrot", "given": "Bastien", "initials": "B", "orcid": "0000-0002-3701-6693", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33acfaa75f8549998703777c8269dcf9.json"}}, {"family": "Challet-Bouju", "given": "Ga\u00eblle", "initials": "G", "orcid": "0000-0002-2238-8005", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8363420fee0d48d294ee8e182fe15b08.json"}}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A", "orcid": "0000-0002-5800-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec14ecdcc0654d8ea864f64ce195752b.json"}}], "type": "journal article", "published": "2023-03-30", "journal": {"title": "J Behav Addict", "issn": "2063-5303", "volume": "12", "issue": "1", "pages": "230-241", "issn-l": null}, "abstract": "The lockdown of sports and gambling venues during the coronavirus disease 2019 (COVID-19) pandemic caused a fear of increased gambling on other online gambling types, with a risk for transfer to more addictive gambling than otherwise. This study aimed to estimate changes in gambling activity during COVID-19-affected periods among all gamblers at a Swedish state-owned gambling operator and to analyse observable sex differences.\n\nThis study included gambling tracking data from the Swedish state-owned gambling operator Svenska Spel Sports & Casino (sports betting, online bingo, casino and poker). All individuals (n = 616,245) who gambled at least once from February 10 to July 19, 2020, were included. The study period was divided into four periods according to their expected level of COVID-19 impact on gambling opportunities: one pre-COVID period and three COVID-affected periods (sports cancellation, emerging return of sports, substantial return of sports).\n\nSports betting experienced an apparent decrease, followed by a gradual normalization and an end level substantially below prepandemic levels. For online bingo, gambling levels increased upon sports interruption and then decreased with the return to normality in sports events but remained higher than baseline levels. We observed a similar trend for online poker during the interruption of sports, but with a lower level than baseline levels when sports events normalized. We noticed a trend favouring online casinos during the sports interruption period regarding gambling intensity but not wagering levels.\n\nDramatic changes in the content of the gambling market may divert some gamblers to other gambling types, but maintained effects could not be demonstrated.", "doi": "10.1556/2006.2022.00089", "pmid": "36995980", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-04-21T15:51:54.771Z", "modified": "2023-04-21T15:51:54.989Z"}, {"entity": "publication", "iuid": "fade921f5e854a09b10132d514e27337", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fade921f5e854a09b10132d514e27337.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fade921f5e854a09b10132d514e27337"}}, "title": "The European landscape on allogeneic haematopoeietic cell transplantation in Chronic Lymphocytic Leukaemia between 2009 and 2019: a perspective from the Chronic Malignancies Working Party of the EBMT.", "authors": [{"family": "Tournilhac", "given": "Olivier", "initials": "O", "orcid": "0000-0002-9438-621X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c13ba4e40e4d4297b137a29cddf780f9.json"}}, {"family": "van Gelder", "given": "Michel", "initials": "M"}, {"family": "Eikema", "given": "Dirk-Jan", "initials": "DJ"}, {"family": "Zinger", "given": "Nienke", "initials": "N"}, {"family": "Dreger", "given": "Peter", "initials": "P", "orcid": "0000-0002-7429-8570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4433ddd0ffe348e8ad1495e385e3fd1e.json"}}, {"family": "Bornh\u00e4user", "given": "Martin", "initials": "M"}, {"family": "Vucinic", "given": "Vladan", "initials": "V", "orcid": "0000-0002-8398-285X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9afc2198e04b4d299fa45298534a9b44.json"}}, {"family": "Scheid", "given": "Christof", "initials": "C"}, {"family": "Cornelissen", "given": "Jan J", "initials": "JJ"}, {"family": "Schroeder", "given": "Thomas", "initials": "T"}, {"family": "Jindra", "given": "Pavel", "initials": "P", "orcid": "0000-0002-8415-7069", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7602c74632d04b3b98a5bb0d01f61096.json"}}, {"family": "Sengeloev", "given": "Henrik", "initials": "H"}, {"family": "Nguyen Quoc", "given": "Stephanie", "initials": "S"}, {"family": "Stelljes", "given": "Matthias", "initials": "M"}, {"family": "Blau", "given": "Igor Wolfgang", "initials": "IW"}, {"family": "Mayer", "given": "Jiri", "initials": "J"}, {"family": "Paneesha", "given": "Shankara", "initials": "S"}, {"family": "Chevallier", "given": "Patrice", "initials": "P", "orcid": "0000-0003-3142-5581", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3232eb710cb4a7bb240a5d54f4ef0c8.json"}}, {"family": "Forcade", "given": "Edouard", "initials": "E", "orcid": "0000-0002-8873-2868", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0bfa707a1104de1a132b827238179d4.json"}}, {"family": "Kr\u00f6ger", "given": "Nicolaus", "initials": "N", "orcid": "0000-0001-5103-9966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bcb76aaf69944eb90bff4dce6a4a29f.json"}}, {"family": "Blaise", "given": "Didier", "initials": "D", "orcid": "0000-0002-5684-9447", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09938f98a7bb4e059076c31cb25eabc5.json"}}, {"family": "Gribben", "given": "John", "initials": "J", "orcid": "0000-0002-8505-7430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c243d093ea4a46e68e7d5c1dd052f1b6.json"}}, {"family": "Nielsen", "given": "Bendt", "initials": "B"}, {"family": "Johansson", "given": "Jan-Erik", "initials": "JE"}, {"family": "Kyriakou", "given": "Charalampia", "initials": "C"}, {"family": "Beguin", "given": "Yves", "initials": "Y"}, {"family": "Pioltelli", "given": "Pietro", "initials": "P"}, {"family": "Sampol", "given": "Ant\u00f2nia", "initials": "A", "orcid": "0000-0001-7465-6203", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0345dd93a2514536b82d3c8da6ef87fb.json"}}, {"family": "McLornan", "given": "Donal P", "initials": "DP", "orcid": "0000-0003-1224-091X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c485d00a7f041a184e6863d5d88e4cc.json"}}, {"family": "Schetelig", "given": "Johannes", "initials": "J"}, {"family": "Hayden", "given": "Patrick J", "initials": "PJ", "orcid": "0000-0003-1374-4503", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7cc7cb029ae44d8289498fd80acb6831.json"}}, {"family": "Yakoub-Agha", "given": "Ibrahim", "initials": "I", "orcid": "0000-0003-4524-8782", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/555e2c08de5347fa8ded53ef415ad9d1.json"}}], "type": "journal article", "published": "2023-03-28", "journal": {"title": "Bone Marrow Transplant", "issn": "1476-5365", "pages": "1-4", "issn-l": "0268-3369"}, "abstract": "Allogeneic transplantation (allo-HCT) is a curative treatment in CLL whose efficacy including the most severe forms had led to the 2006 EBMT recommendations. The advent after 2014 of targeted therapies has revolutionized CLL management, allowing prolonged control to patients who have failed immunochemotherapy and/or have TP53 alterations. We analysed the pre COVID pandemic 2009-2019 EBMT registry. The yearly number of allo-HCT raised to 458 in 2011 yet dropped from 2013 onwards to an apparent plateau above 100. Within the 10 countries who were under the EMA for drug approval and performed 83.5% of those procedures, large initial differences were found but the annual number converged to 2-3 per 10 million inhabitants during the 3 most recent years suggesting that allo-HCT remains applied in selected patients. Long-term follow-up on targeted therapies shows that most patients relapse, some early, with risk factors and resistance mechanisms being described. The treatment of patients exposed to both BCL2 and BTK inhibitors and especially those with double refractory disease will become a challenge in which allo-HCT remains a solid option in competition with emerging therapies that have yet to demonstrate their long-term effectiveness.", "doi": "10.1038/s41409-023-01955-z", "pmid": "36977926", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10044103"}, {"db": "pii", "key": "10.1038/s41409-023-01955-z"}], "notes": [], "created": "2023-04-21T15:58:41.357Z", "modified": "2023-04-21T15:58:52.731Z"}, {"entity": "publication", "iuid": "570b29c77de54cf882aad5ca3c22eb43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/570b29c77de54cf882aad5ca3c22eb43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/570b29c77de54cf882aad5ca3c22eb43"}}, "title": "Medical Applications of Nonadditive Entropies.", "authors": [{"family": "Tsallis", "given": "Constantino", "initials": "C", "orcid": "0000-0002-9387-9194", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89cbe0c088dc48f69f0339c432b01c29.json"}}, {"family": "Pasechnik", "given": "Roman", "initials": "R", "orcid": "0000-0003-4231-0149", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce22e54b098840a98f8f0bfafc3f1759.json"}}], "type": "journal article", "published": "2023-03-28", "journal": {"title": "Entropy (Basel)", "issn": "1099-4300", "issn-l": null, "volume": "25", "issue": "4", "pages": null}, "abstract": "The Boltzmann-Gibbs additive entropy SBG=-k\u2211ipilnpi and associated statistical mechanics were generalized in 1988 into nonadditive entropy Sq=k1-\u2211ipiqq-1 and nonextensive statistical mechanics, respectively. Since then, a plethora of medical applications have emerged. In the present review, we illustrate them by briefly presenting image and signal processings, tissue radiation responses, and modeling of disease kinetics, such as for the COVID-19 pandemic.", "doi": "10.3390/e25040578", "pmid": "37190366", "labels": {"Type: Review": null, "Category: Imaging": null}, "xrefs": [{"db": "pmc", "key": "PMC10137456"}, {"db": "pii", "key": "e25040578"}], "notes": [], "created": "2023-10-04T05:11:56.921Z", "modified": "2023-10-04T07:23:35.843Z"}, {"entity": "publication", "iuid": "9a7a008ce380464d8e01b86a3fe63a4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9a7a008ce380464d8e01b86a3fe63a4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9a7a008ce380464d8e01b86a3fe63a4c"}}, "title": "A Case Series on Pregnant Patients with Mild Covid-19 Infection and Signs of Severe Placental Insufficiency.", "authors": [{"family": "Ivert", "given": "A", "initials": "A", "orcid": "0000-0002-3739-1725", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ced16f5a5ab24db6aa5aec2b2c9c12f6.json"}}, {"family": "Lindblad Wollmann", "given": "C", "initials": "C"}, {"family": "Pettersson", "given": "K", "initials": "K"}], "type": "case reports", "published": "2023-03-28", "journal": {"title": "Case Rep Obstet Gynecol", "issn": "2090-6684", "volume": "2023", "pages": "2018551", "issn-l": null}, "abstract": "In this case series, we present five cases of pregnant women who sought medical attention for reduced fetal movements with an ongoing mild maternal Covid-19 infection at a Stockholm hospital in Spring of 2021. At the time of admission, the patients were in gestational week between 24 + 0 and 33 + 5. Abdominal ultrasound at the hospital showed no fetal movements, and cardiotocography (CTG) was pathological. All women delivered via cesarean section within 24 hours after admission. Placental pathology in all cases showed massive perivillous fibrin deposition and extensive histiocytic intervillositis. All placentas were Covid-19 polymerase chain reaction (PCR) positive. The infants were Covid-19 PCR negative. Consistent with other published case reports, we hypothesize that Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect the placenta resulting in massive perivillous fibrin deposition and histiocytic intervillositis leading to acute placental insufficiency and fetal hypoxia. The absence of intrauterine growth restriction also augments the theory of an acute onset of placental insufficiency due to the Covid-19 infection.", "doi": "10.1155/2023/2018551", "pmid": "37025388", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10072962"}], "notes": [], "created": "2023-04-20T17:30:38.579Z", "modified": "2023-04-20T17:30:38.645Z"}, {"entity": "publication", "iuid": "8cb3831d70fc4818aea5cee4def8092f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8cb3831d70fc4818aea5cee4def8092f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8cb3831d70fc4818aea5cee4def8092f"}}, "title": "Sexual and reproductive health in Britain during the first year of the COVID-19 pandemic: cross-sectional population survey (Natsal-COVID-Wave 2) and national surveillance data.", "authors": [{"family": "Mitchell", "given": "Kirstin R", "initials": "KR", "orcid": "0000-0002-4409-6601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2af6a4b606314786806e669e86b92ee0.json"}}, {"family": "Willis", "given": "Malachi", "initials": "M", "orcid": "0000-0002-3173-3990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ca9dea31fdbd4c4db30607d7f3b274fd.json"}}, {"family": "Dema", "given": "Emily", "initials": "E", "orcid": "0000-0002-7254-2023", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3843a1be6fc4e37ac3f8eeff9a2bbb2.json"}}, {"family": "Baxter", "given": "Andrew J", "initials": "AJ", "orcid": "0000-0002-7654-9687", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9814cc9ab7534effba5c569aab450cc4.json"}}, {"family": "Connolly", "given": "Anne", "initials": "A", "orcid": "0000-0003-4953-2182", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65548be760514e228167f010b442043d.json"}}, {"family": "Riddell", "given": "Julie", "initials": "J", "orcid": "0000-0002-8084-4566", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9660f5597db42d19462b83c9f8a1be4.json"}}, {"family": "Bos\u00f3 P\u00e9rez", "given": "Raquel", "initials": "R", "orcid": "0000-0001-7342-4566", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3d61e70a5874b4ea43a1d9d73333605.json"}}, {"family": "Clifton", "given": "Soazig", "initials": "S", "orcid": "0000-0002-4171-0805", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7cea96a2c56409dab9f474144303c30.json"}}, {"family": "Gibbs", "given": "Jo", "initials": "J", "orcid": "0000-0001-5696-0260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8e88ce8b71e4ae3b03749616b5a9eab.json"}}, {"family": "Tanton", "given": "Clare", "initials": "C", "orcid": "0000-0002-4612-1858", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adf2ed41e93f422aa32a1afe93895bed.json"}}, {"family": "Geary", "given": "Rebecca", "initials": "R", "orcid": "0000-0003-1417-1057", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a696d4c9c6024ce58dbcc443326bf362.json"}}, {"family": "Ratna", "given": "Natasha", "initials": "N", "orcid": "0000-0002-8848-7938", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1913b5456b1044e4a0c3f93aa7405fa7.json"}}, {"family": "Mohammed", "given": "Hamish", "initials": "H", "orcid": "0000-0002-2060-7286", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54be4ca28b4b44f7939f51de5f34077c.json"}}, {"family": "Unemo", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1710-2081", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed8c616c8c16456590342443393553cb.json"}}, {"family": "Bonell", "given": "Christopher", "initials": "C", "orcid": "0000-0002-6253-6498", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eeec7c46459414a974c9f42cc3b2baa.json"}}, {"family": "Copas", "given": "Andrew", "initials": "A", "orcid": "0000-0001-8968-5963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0aee9dde1bb2497398a63252a713c88a.json"}}, {"family": "Sonnenberg", "given": "Pam", "initials": "P", "orcid": "0000-0002-1067-1583", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/703eb395b191407eb977ed908453cb30.json"}}, {"family": "Mercer", "given": "Catherine H", "initials": "CH", "orcid": "0000-0002-4220-5034", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6332e0448a8b49c7ab019b7c75768df1.json"}}, {"family": "Field", "given": "Nigel", "initials": "N", "orcid": "0000-0002-2825-6652", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a84330facf864cfe9a4a51550cea9543.json"}}], "type": "journal article", "published": "2023-03-27", "journal": {"title": "Sex Transm Infect", "issn": "1472-3263", "issn-l": "1368-4973"}, "abstract": "To assess sexual behaviour, and sexual and reproductive health (SRH) outcomes, after 1 year of the COVID-19 pandemic in Britain.\n\n6658 participants aged 18-59 and resident in Britain completed a cross-sectional web-panel survey (Natsal-COVID-Wave 2, March-April 2021), 1 year after the first lockdown. Natsal-COVID-2 follows the Natsal-COVID-Wave 1 survey (July-August 2020) which captured impacts in the initial months. Quota-based sampling and weighting resulted in a quasi-representative population sample. Data were contextualised with reference to the most recent probability sample population data (Natsal-3; collected 2010-12; 15 162 participants aged 16-74) and national surveillance data on recorded sexually transmitted infection (STI) testing, conceptions, and abortions in England/Wales (2010-2020). The main outcomes were: sexual behaviour; SRH service use; pregnancy, abortion and fertility management; sexual dissatisfaction, distress and difficulties.\n\nIn the year from the first lockdown, over two-thirds of participants reported one or more sexual partners (women 71.8%; men 69.9%), while fewer than 20.0% reported a new partner (women 10.4%; men 16.8%). Median occasions of sex per month was two. Compared with 2010-12 (Natsal-3), we found less sexual risk behaviour (lower reporting of multiple partners, new partners, and new condomless partners), including among younger participants and those reporting same-sex behaviour. One in 10 women reported a pregnancy; pregnancies were fewer than in 2010-12 and less likely to be scored as unplanned. 19.3% of women and 22.8% of men were distressed or worried about their sex life, significantly more than in 2010-12. Compared with surveillance trends from 2010 to 2019, we found lower than expected use of STI-related services and HIV testing, lower levels of chlamydia testing, and fewer conceptions and abortions.\n\nOur findings are consistent with significant changes in sexual behaviour, SRH, and service uptake in the year following the first lockdown in Britain. These data are foundational to SRH recovery and policy planning.", "doi": "10.1136/sextrans-2022-055680", "pmid": "36973042", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "sextrans-2022-055680"}], "notes": [], "created": "2023-04-21T15:59:49.563Z", "modified": "2023-04-21T15:59:49.823Z"}, {"entity": "publication", "iuid": "a074c5ca733b4ae4896ac4c4e4adb77a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a074c5ca733b4ae4896ac4c4e4adb77a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a074c5ca733b4ae4896ac4c4e4adb77a"}}, "title": "Proteomic characteristics and diagnostic potential of exhaled breath particles in patients with COVID-19.", "authors": [{"family": "Hirdman", "given": "Gabriel", "initials": "G"}, {"family": "Bod\u00e9n", "given": "Embla", "initials": "E"}, {"family": "Kjellstr\u00f6m", "given": "Sven", "initials": "S"}, {"family": "Fraenkel", "given": "Carl-Johan", "initials": "CJ"}, {"family": "Olm", "given": "Franziska", "initials": "F"}, {"family": "Hallgren", "given": "Oskar", "initials": "O"}, {"family": "Lindstedt", "given": "Sandra", "initials": "S"}], "type": "journal article", "published": "2023-03-27", "journal": {"title": "Clin Proteomics", "issn": "1542-6416", "volume": "20", "issue": "1", "pages": "13", "issn-l": null}, "abstract": "SARS-CoV-2 has been shown to predominantly infect the airways and the respiratory tract and too often have an unpredictable and different pathologic pattern compared to other respiratory diseases. Current clinical diagnostical tools in pulmonary medicine expose patients to harmful radiation, are too unspecific or even invasive. Proteomic analysis of exhaled breath particles (EBPs) in contrast, are non-invasive, sample directly from the pathological source and presents as a novel explorative and diagnostical tool.\n\nPatients with PCR-verified COVID-19 infection (COV-POS, n = 20), and patients with respiratory symptoms but with > 2 negative polymerase chain reaction (PCR) tests (COV-NEG, n = 16) and healthy controls (HCO, n = 12) were prospectively recruited. EBPs were collected using a \"particles in exhaled air\" (PExA 2.0) device. Particle per exhaled volume (PEV) and size distribution profiles were compared. Proteins were analyzed using liquid chromatography-mass spectrometry. A random forest machine learning classification model was then trained and validated on EBP data achieving an accuracy of 0.92.\n\nSignificant increases in PEV and changes in size distribution profiles of EBPs was seen in COV-POS and COV-NEG compared to healthy controls. We achieved a deep proteome profiling of EBP across the three groups with proteins involved in immune activation, acute phase response, cell adhesion, blood coagulation, and known components of the respiratory tract lining fluid, among others. We demonstrated promising results for the use of an integrated EBP biomarker panel together with particle concentration for diagnosis of COVID-19 as well as a robust method for protein identification in EBPs.\n\nOur results demonstrate the promising potential for the use of EBP fingerprints in biomarker discovery and for diagnosing pulmonary diseases, rapidly and non-invasively with minimal patient discomfort.", "doi": "10.1186/s12014-023-09403-2", "pmid": "36967377", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10040313"}, {"db": "pii", "key": "10.1186/s12014-023-09403-2"}], "notes": [], "created": "2023-04-21T16:02:51.349Z", "modified": "2023-04-21T16:03:10.432Z"}, {"entity": "publication", "iuid": "d6b973d57dd049d3a1c9caa7041b4b4f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d6b973d57dd049d3a1c9caa7041b4b4f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d6b973d57dd049d3a1c9caa7041b4b4f"}}, "title": "Flares in autoimmune rheumatic diseases in the post-COVID-19 vaccination period - A Cross-sequential study based on COVAD surveys.", "authors": [{"family": "Jagtap", "given": "Kshitij", "initials": "K", "orcid": "0000-0003-2729-737X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822b9da98e5d4eb2975ff97fe484933f.json"}}, {"family": "R", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Vaidya", "given": "Binit", "initials": "B", "orcid": "0000-0002-4840-8924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b2296d53fe14fc7a8415f26e03e1944.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-0986-8354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2e6226ae5e7427fbf52e180dd14e28f.json"}}, {"family": "Saha", "given": "Sreoshy", "initials": "S", "orcid": "0000-0001-6745-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00238845dd4833ae51ffb75e2fe144.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Edgar Gracia-Ramos", "given": "Abraham", "initials": "A", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}, {"family": "Patel", "given": "Aarat", "initials": "A"}, {"family": "Pauling", "given": "John D", "initials": "JD", "orcid": "0000-0002-2793-2364", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e37709273d404d17a88c7c850777b99f.json"}}, {"family": "Wincup", "given": "Chris", "initials": "C", "orcid": "0000-0002-8742-8311", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a674f02e7f7f45f58167eb24f81502f3.json"}}, {"family": "Barman", "given": "Bhupen", "initials": "B", "orcid": "0000-0002-5433-1310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7747785ec5fa4743bc70bd20fbca10fd.json"}}, {"family": "Zamora Tehozol", "given": "Erick Adrian", "initials": "EA", "orcid": "0000-0002-7888-3961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a55c695ac4f4003993a2f511cca7739.json"}}, {"family": "Serrano", "given": "Jorge Rojas", "initials": "JR", "orcid": "0000-0001-6980-7898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/225fd8b396ac40f4a77f1ec229c086b6.json"}}, {"family": "Garc\u00eda-De La Torre", "given": "Ignacio", "initials": "I", "orcid": "0000-0002-9261-678X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/086b85d66fb84b50bd51bbe5a979dfe3.json"}}, {"family": "Colunga-Pedraza", "given": "Iris J", "initials": "IJ", "orcid": "0000-0002-2786-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50e46ef2c7f44b39a1d28fea6a8e621d.json"}}, {"family": "Merayo-Chalico", "given": "Javier", "initials": "J", "orcid": "0000-0002-5870-0523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d74c0ab33cbe4df586e1a1add37d0e65.json"}}, {"family": "Chibuzo", "given": "Okwara Celestine", "initials": "OC", "orcid": "0000-0002-7727-5657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f415c3f3dea49cb90ae12def4278f00.json"}}, {"family": "Katchamart", "given": "Wanruchada", "initials": "W", "orcid": "0000-0002-8952-5967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9439933b38fb49aca8fdbb5038ff603c.json"}}, {"family": "Goo", "given": "Phonpen Akawatcharangura", "initials": "PA"}, {"family": "Shumnalieva", "given": "Russka", "initials": "R", "orcid": "0000-0003-2321-6536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/933232cd7feb48ee81b5971f01f52e23.json"}}, {"family": "Chen", "given": "Yi-Ming", "initials": "YM", "orcid": "0000-0001-7593-3065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/795f1bf1d4824521a3301f7c50f62bc4.json"}}, {"family": "Hoff", "given": "Leonardo Santos", "initials": "LS", "orcid": "0000-0002-2083-4796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1df7af8caf024ca39c57278fdf18c766.json"}}, {"family": "El Kibbi", "given": "Lina", "initials": "L", "orcid": "0000-0003-1710-9996", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11bb4fc524264c6897dec9642a0ef7cd.json"}}, {"family": "Halabi", "given": "Hussein", "initials": "H", "orcid": "0000-0002-5174-8292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb337090a5ab4461a07e8620bee1b4b9.json"}}, {"family": "Sazliyana Shaharir", "given": "Syahrul", "initials": "S", "orcid": "0000-0002-9068-8114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1e6310979d44d58b548c61c733412af.json"}}, {"family": "Hasan", "given": "A T M Tanveer", "initials": "ATMT", "orcid": "0000-0002-5332-3319", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ffdb3329292438fac4005923ee79012.json"}}, {"family": "Dey", "given": "Dzifa", "initials": "D", "orcid": "0000-0002-3339-5112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2615e43aeba34a0585679bdd14a1a324.json"}}, {"family": "Guti\u00e9rrez", "given": "Carlos Enrique Toro", "initials": "CET", "orcid": "0000-0002-6084-7049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/980e455c5d114caaaefb6e0b55eaa3b3.json"}}, {"family": "Caballero-Uribe", "given": "Carlo Vinicio", "initials": "CV", "orcid": "0000-0002-9845-8620", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42d86c9923424f9a804bab4580b993c3.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "COVAD study group", "given": "", "initials": ""}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}], "type": "journal article", "published": "2023-03-24", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "issn-l": null}, "abstract": "Flares of autoimmune rheumatic disease (AIRDs) following COVID-19 vaccination are an outstanding concern in vaccine-hesitant individuals. Therefore, we investigated the incidence, predictors and patterns of flares following vaccination in individuals living with AIRDs using global COVID-19 Vaccination in Autoimmune Diseases (COVAD) surveys.\n\nThe COVAD surveys were used to extract data on flare demographics, comorbidities, COVID-19 history, and vaccination details among patients with AIRDs. Flares following vaccination were identified as patient-reported(a), increased immunosuppression(b), clinical exacerbations(c) and worsening of PROMIS scores(d). We studied flare characteristics and used regression models to differentiate flares among various AIRDs.\n\nOf 15165 total responses, the incidence of flares in 3453 patients with AIRDs was 11.3%, 14.8%, 9.5%, and 26.7% by definitions a-d, respectively. There was moderate agreement between patient-reported and immunosuppression-defined flares (K = 0.403, p = 0.022). Arthritis (61.6%) and fatigue (58.8%) were the most commonly reported symptoms. Self-reported flares were associated with higher comorbidities (p = 0.013), mental health disorders (MHD) (p < 0.001), and autoimmune multimorbidity (AIDm) (p < 0.001).In regression analysis, the presence of AIDm (OR = 1.4;95%CI:1.1-1.7;p=0.003), MHD (OR = 1.7;95%CI:1.1-2.6;p=0.007), and Moderna vaccine (OR = 1.5;95%CI:1.09-2.2;p=0.014) recipients were predictors of flares. Mycophenolate (OR = 0.5;95%CI:0.3-0.8;p=0.009) and glucocorticoids (OR = 0.6;95%CI:0.5-0.8;p=0.003) were protective.A higher frequency of patients with AIRDs reported overall active disease post-vaccination compared to before vaccination (OR = 1.3;95%CI:1.1-1.5;p<0.001).\n\nFlares occur in nearly one in ten individuals with AIRDs after COVID vaccination, with people with comorbidities, especially AID multimorbidity, mental health disorders and use of the Moderna vaccine being particularly vulnerable. Future avenues include exploring flare profiles and optimizing vaccine strategies for this group.", "doi": "10.1093/rheumatology/kead144", "pmid": "36961331", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7085591"}], "notes": [], "created": "2023-04-21T16:03:32.208Z", "modified": "2023-04-21T16:03:32.559Z"}, {"entity": "publication", "iuid": "86e00e5653a54fabbc9a2f6decb2ad37", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86e00e5653a54fabbc9a2f6decb2ad37.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86e00e5653a54fabbc9a2f6decb2ad37"}}, "title": "Syndemic health crises-The growing role of National Public Health Institutes in shaping a coordinated response.", "authors": [{"family": "Tweed", "given": "Sam", "initials": "S", "orcid": "0000-0002-6395-8422", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f2abaf594474ad5a8c3a79edd012803.json"}}, {"family": "Selbie", "given": "Duncan", "initials": "D"}, {"family": "Tegnell", "given": "Anders", "initials": "A"}, {"family": "Viso", "given": "Anne-Catherine", "initials": "AC"}, {"family": "Ahmed", "given": "Abdifatah", "initials": "A"}, {"family": "Mastkov", "given": "Oleksandr", "initials": "O"}, {"family": "Pendergast", "given": "Scott", "initials": "S"}, {"family": "Squires", "given": "Neil", "initials": "N"}], "type": "journal article", "published": "2023-03-23", "journal": {"title": "Int J Health Plann Manage", "issn": "1099-1751", "issn-l": null}, "abstract": "Countries across the world are experiencing syndemic health crises where infectious pathogens including COVID-19 interact with epidemics of communicable and non-communicable diseases. Combined with war, environmental instability and the effects of soaring inflation, a public health crisis has emerged requiring an integrated response. Increasingly, national public health institutes (NPHIs) are at the forefront of leading this, as demonstrated at the 2022 Annual Meeting of the International Association of National Public Health Institutes (IANPHI). These effects are particularly evident where conflict is exacerbating health crises in Ukraine and Somalia. In Ukraine, medical and public health workers have been killed and infrastructure destroyed, which require major efforts to rebuild to international standards. In Somalia, these crises are magnified by the effects of climate change, leading to greater food insecurity, heat-related deaths and famine. National public health institutes are crucial in these contexts and many others to support integrated political responses where health challenges span local, national and international levels and involve multiple stakeholders. This can be seen in strengthening of Integrated Disease Surveillance and work towards the Sustainable Development Goals. National public health institutes also provide integration through the international system, working jointly to build national capacities to deliver essential public health functions. In this context, the 2022 IANPHI Annual meeting agreed the Stockholm Statement, highlighting the role that NPHIs play in tackling the causes and effects of interconnected global and local challenges to public health. This represents an important step in addressing complex health crises and syndemics which require whole-of-society responses, with NPHIs uniquely placed to work across sectors and provide system leadership in response.", "doi": "10.1002/hpm.3634", "pmid": "36959725", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-04-21T16:05:09.001Z", "modified": "2023-04-21T16:05:09.062Z"}, {"entity": "publication", "iuid": "2e4797c19d1e4d4ea6981a7c30418394", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e4797c19d1e4d4ea6981a7c30418394.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e4797c19d1e4d4ea6981a7c30418394"}}, "title": "Involuntary Resistance.", "authors": [{"family": "Baaz", "given": "Mikael", "initials": "M"}, {"family": "Lilja", "given": "Mona", "initials": "M", "orcid": "0000-0003-2773-8534", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9bb2b4cd78b74bab81987a2d1c2ab943.json"}}, {"family": "Wallgren", "given": "Malin", "initials": "M"}], "type": "journal article", "published": "2023-03-23", "journal": {"title": "Int J Polit Cult Soc", "issn": "0891-4486", "issn-l": null, "volume": null, "issue": null, "pages": "1-21"}, "abstract": "This paper problematizes the notion of \"intent\" through the concept of \"involuntary resistance\". Departing from the narratives of employees in nursing homes in Sweden during the Covid-19 pandemic in 2020 and 2021, we suggest that neoliberal norms and a local management that capitalizes on social hierarchies (sex, age, class, etc.) were the context of the strong biopolitical state management that occurred due to the Covid-19 pandemic. The friction between different forms of governing became a seedbed for an involuntary resistance with an unclear intent against the state recommendations. This sheds light upon the need to (re)frame the current dominance of specific types of knowledge that are constructed in the field of resistance. We suggest that new paths of thought are needed-within social sciences-that work towards a wider conceptualizing of resistance, which embraces practices that lie outside the common thought of dissent.", "doi": "10.1007/s10767-023-09442-5", "pmid": "37361706", "labels": {"Category: Social Science & Humanities": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC10034246"}, {"db": "pii", "key": "9442"}], "notes": [], "created": "2023-10-04T09:31:43.756Z", "modified": "2023-10-04T10:52:59.715Z"}, {"entity": "publication", "iuid": "b3ca239b5db743f2a50b5cd6f7e41585", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b3ca239b5db743f2a50b5cd6f7e41585.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b3ca239b5db743f2a50b5cd6f7e41585"}}, "title": "Community participatory learning and action cycle groups to reduce type 2 diabetes in Bangladesh (D:Clare): an updated study protocol for a parallel arm cluster randomised controlled trial.", "authors": [{"family": "King", "given": "Carina", "initials": "C"}, {"family": "Pires", "given": "Malini", "initials": "M"}, {"family": "Ahmed", "given": "Naveed", "initials": "N"}, {"family": "Akter", "given": "Kohenour", "initials": "K"}, {"family": "Kuddus", "given": "Abdul", "initials": "A"}, {"family": "Copas", "given": "Andrew", "initials": "A"}, {"family": "Haghparast-Bidgoli", "given": "Hassan", "initials": "H"}, {"family": "Morrison", "given": "Joanna", "initials": "J"}, {"family": "Nahar", "given": "Tasmin", "initials": "T"}, {"family": "Shaha", "given": "Sanjit Kumer", "initials": "SK"}, {"family": "Khan", "given": "AKAzad", "initials": "A"}, {"family": "Azad", "given": "Kishwar", "initials": "K"}, {"family": "Fottrell", "given": "Edward", "initials": "E", "orcid": "0000-0003-0518-7161", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb5f48cd80b4425984648f889a2a2b45.json"}}], "type": "clinical trial protocol", "published": "2023-03-23", "journal": {"title": "Trials", "issn": "1745-6215", "volume": "24", "issue": "1", "pages": "218", "issn-l": null}, "abstract": "The \"Diabetes: Community-led Awareness, Response and Evaluation\" (D:Clare) trial aims to scale up and replicate an evidence-based participatory learning and action cycle intervention in Bangladesh, to inform policy on population-level T2DM prevention and control.The trial was originally designed as a stepped-wedge cluster randomised controlled trial, with the interventions running from March 2020 to September 2022. Twelve clusters were randomly allocated (1:1) to implement the intervention at months 1 or 12 in two steps, and evaluated through three cross-sectional surveys at months 1, 12 and 24. However, due to the COVID-19 pandemic, we suspended project activities on the 20th of March 2020. As a result of the changed risk landscape and the delays introduced by the COVID-19 pandemic, we changed from the stepped-wedge design to a wait-list parallel arm cluster RCT (cRCT) with baseline data. We had four key reasons for eventually agreeing to change designs: equipoise, temporal bias in exposure and outcomes, loss of power and time and funding considerations.Trial registration ISRCTN42219712 . Registered on 31 October 2019.", "doi": "10.1186/s13063-023-07243-x", "pmid": "36959617", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10034243"}, {"db": "pii", "key": "10.1186/s13063-023-07243-x"}], "notes": [], "created": "2023-04-21T16:05:31.152Z", "modified": "2023-04-21T16:05:31.188Z"}, {"entity": "publication", "iuid": "3c95dafecf78407bbfb32294e1d5700e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3c95dafecf78407bbfb32294e1d5700e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3c95dafecf78407bbfb32294e1d5700e"}}, "title": "Health progression for Covid-19 survivors hospitalized in geriatric clinics in Sweden.", "authors": [{"family": "Kananen", "given": "Laura", "initials": "L", "orcid": "0000-0003-3742-8927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d8f660eb3e4490f8d6d2d12b773d92d.json"}}, {"family": "Hong", "given": "Xu", "initials": "X"}, {"family": "Annetorp", "given": "Martin", "initials": "M"}, {"family": "Mak", "given": "Jonathan K L", "initials": "JKL", "orcid": "0000-0003-4454-8580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4ec879e8b4a4879af61239068143893.json"}}, {"family": "Jylh\u00e4v\u00e4", "given": "Juulia", "initials": "J"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}, {"family": "H\u00e4gg", "given": "Sara", "initials": "S"}, {"family": "Religa", "given": "Dorota", "initials": "D"}], "type": "journal article", "published": "2023-03-22", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "18", "issue": "3", "pages": "e0283344", "issn-l": "1932-6203"}, "abstract": "To analyse if the health progression of geriatric Covid-19 survivors three months after an acute Covid-19 infection was worse than in other geriatric patients. Specifically, we wanted to see if we could see distinct health profiles in the flow of re-admitted Covid-19 patients compared to re-admitted non-Covid-19 controls.\n\nMatched cohort study.\n\nElectronic medical records of geriatric patients hospitalised in geriatric clinics in Stockholm, Sweden, between March 2020 and January 2022. Patients readmitted three months after initial admission were selected for the analysis and Covid-19 survivors (n = 895) were compared to age-sex-Charlson comorbidity index (CCI)-matched non-Covid-19 controls (n = 2685).\n\nWe assessed using binary logistic and Cox regression if a previous Covid-19 infection could be a risk factor for worse health progression indicated by the CCI, hospital frailty risk score (HFRS), mortality and specific comorbidities.\n\nThe patients were mostly older than 75 years and, already at baseline, had typically multiple comorbidities. The Covid-19 patients with readmission had mostly had their acute-phase infection in the 1st or 2nd pandemic waves before the vaccinations. The Covid-19 patients did not have worse health after three months compared to the matched controls according to the CCI (odds ratio, OR[95% confidence interval, CI] = 1.12[0.94-1.34]), HFRS (OR[95%CI] = 1.05[0.87-1.26]), 6-months (hazard ratio, HR[95%CI] = 1.04[0.70-1.52]) and 1-year-mortality risk (HR[95%CI] = 0.89[0.71-1.10]), adjusted for age, sex and health at baseline (the CCI and HFRS).\n\nThe overall health progression of re-hospitalized geriatric Covid-19 survivors did not differ dramatically from other re-hospitalized geriatric patients with similar age, sex and health at baseline. Our results emphasize that Covid-19 was especially detrimental for geriatric patients in the acute-phase, but not in the later phase. Further studies including post-vaccination samples are needed.", "doi": "10.1371/journal.pone.0283344", "pmid": "36947542", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10032538"}, {"db": "pii", "key": "PONE-D-22-21870"}], "notes": [], "created": "2023-04-21T16:06:57.286Z", "modified": "2023-04-21T16:06:57.365Z"}, {"entity": "publication", "iuid": "3f8d510834ab41f097f8cfa99a8c238f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f8d510834ab41f097f8cfa99a8c238f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f8d510834ab41f097f8cfa99a8c238f"}}, "title": "Correlates of protection and viral load trajectories in omicron breakthrough infections in triple vaccinated healthcare workers.", "authors": [{"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Norin", "given": "Nina Greilert", "initials": "NG"}, {"family": "Bladh", "given": "Oscar", "initials": "O"}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f2dc27d02294a15a6f691be6aab641f.json"}}, {"family": "Gordon", "given": "Max", "initials": "M", "orcid": "0000-0002-8080-5815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b07b91dec1424185a3e8ee6c8bbf00d7.json"}}, {"family": "Ng", "given": "Henry", "initials": "H"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Phillipson", "given": "Mia", "initials": "M", "orcid": "0000-0002-2387-0266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/614a4a6f69204c6287a81a79a1a7a8f1.json"}}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "Alm", "given": "Jessica J", "initials": "JJ"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2023-03-22", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "1577", "issn-l": "2041-1723"}, "abstract": "Vaccination offers protection against severe COVID-19 caused by SARS-CoV-2 omicron but is less effective against infection. Characteristics such as serum antibody titer correlation to protection, viral abundance and clearance of omicron infection in vaccinated individuals are scarce. We present a 4-week twice-weekly SARS-CoV-2 qPCR screening in 368 triple vaccinated healthcare workers. Spike-specific IgG levels, neutralization titers and mucosal spike-specific IgA-levels were determined at study start and qPCR-positive participants were sampled repeatedly for two weeks. 81 (cumulative incidence 22%) BA.1, BA.1.1 and BA.2 infections were detected. High serum antibody titers are shown to be protective against infection (p < 0.01), linked to reduced viral load (p < 0.01) and time to viral clearance (p < 0.05). Pre-omicron SARS-CoV-2 infection is independently associated to increased protection against omicron, largely mediated by mucosal spike specific IgA responses (nested models lr test p = 0.02 and 0.008). Only 10% of infected participants remain asymptomatic through the course of their infection. We demonstrate that high levels of vaccine-induced spike-specific WT antibodies are linked to increased protection against infection and to reduced viral load if infected, and suggest that the additional protection offered by pre-omicron SARS-CoV-2 infection largely is mediated by mucosal spike-specific IgA.", "doi": "10.1038/s41467-023-36984-1", "pmid": "36949041", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Omicron VoC": null}, "xrefs": [{"db": "pmc", "key": "PMC10031702"}, {"db": "pii", "key": "10.1038/s41467-023-36984-1"}], "notes": [], "created": "2023-04-21T16:06:33.901Z", "modified": "2023-06-19T14:26:54.012Z"}, {"entity": "publication", "iuid": "0f8947530b744d4286909af61fbb33c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0f8947530b744d4286909af61fbb33c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0f8947530b744d4286909af61fbb33c5"}}, "title": "Clinical pathway of COVID-19 patients in primary health care in 30 European countries: Eurodata study.", "authors": [{"family": "Ares-Blanco", "given": "Sara", "initials": "S", "orcid": "0000-0002-4984-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5929b4be5ff946a2af9b33fde3fb09ec.json"}}, {"family": "Guisado-Clavero", "given": "Marina", "initials": "M", "orcid": "0000-0002-8448-2929", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe6cb00ce6e64ea9ae551a4a65c1093c.json"}}, {"family": "Ramos Del Rio", "given": "Lourdes", "initials": "L", "orcid": "0000-0003-4850-2053", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/629e28d8cf1d4ba3926ba037e14f5742.json"}}, {"family": "Gefaell Larrondo", "given": "Ileana", "initials": "I", "orcid": "0000-0002-1635-1003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a6e202b315e4966a1fc58919d4f4e4e.json"}}, {"family": "Fitzgerald", "given": "Louise", "initials": "L", "orcid": "0009-0009-8039-3097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54a11aeb7912445e91a8861314dc9dc3.json"}}, {"family": "Adler", "given": "Limor", "initials": "L", "orcid": "0000-0002-9335-6596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d78ad3257d4a4337b7dcdf9922159290.json"}}, {"family": "Assenova", "given": "Radost", "initials": "R", "orcid": "0000-0003-2158-5792", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ded85b8b782e4e58aef1767e73bd5c8e.json"}}, {"family": "Bakola", "given": "Maria", "initials": "M", "orcid": "0000-0002-9016-9322", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6da94c24ddbe4917aba9f082cc0de1c0.json"}}, {"family": "Bayen", "given": "Sabine", "initials": "S", "orcid": "0000-0002-3334-9394", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/97df8a37f1314326b345c4d55fe81941.json"}}, {"family": "Brutskaya-Stempkovskaya", "given": "Elena", "initials": "E"}, {"family": "Busneag", "given": "Iliana-Carmen", "initials": "IC", "orcid": "0000-0001-5611-4312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/980a841d76cd48ed81d4187314a10e3f.json"}}, {"family": "Domeyer", "given": "Philippe-Richard", "initials": "PR", "orcid": "0000-0003-4594-1202", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/223b4565009340998b3fb347d5d62450.json"}}, {"family": "Gjorgjievski", "given": "Dragan", "initials": "D", "orcid": "0000-0003-1817-7632", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/196c52fd9c7c4214a6ae708ed49aa08e.json"}}, {"family": "Hoffmann", "given": "Kathryn", "initials": "K", "orcid": "0000-0001-8760-4250", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/97efc06959c84715a62389edbb78f5d6.json"}}, {"family": "\u0406\u043b\u044c\u043a\u043e\u0432", "given": "\u041e\u043a\u0441\u0430\u043d\u0430", "initials": "\u041e", "orcid": "0000-0002-0923-0596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3902996bf15440c4b6f9491b17d40e61.json"}}, {"family": "Trifon Karathanos", "given": "Vasilis", "initials": "V"}, {"family": "Kirkovski", "given": "Aleksandar", "initials": "A", "orcid": "0000-0001-9002-7028", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e2e11e53a2444799bb3af8d1c6fd951.json"}}, {"family": "Kne\u017eevi\u0107", "given": "Sne\u017eana", "initials": "S", "orcid": "0000-0001-9137-2122", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d71f49de1734f4cb1d5c8d601d32dec.json"}}, {"family": "\u00c7imen Korkmaz", "given": "B\u00fcsra", "initials": "B", "orcid": "0000-0001-7224-5734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ac217a7408242f7920df89fdc6c053f.json"}}, {"family": "Heleno", "given": "Bruno", "initials": "B", "orcid": "0000-0002-3943-1858", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/298ecb30af3b4dd39acadc195016c729.json"}}, {"family": "Nessler", "given": "Katarzyna", "initials": "K", "orcid": "0000-0001-9869-7923", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b12b696d11b34519b8cb27cd01db009a.json"}}, {"family": "Murauskien\u0117", "given": "Liubov\u0117", "initials": "L", "orcid": "0000-0002-6625-8843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5196c9522ef74c82a5a5efc07196e3e2.json"}}, {"family": "Neves", "given": "Ana Luisa", "initials": "AL", "orcid": "0000-0002-7107-7211", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/313da3100a6143a5bfa50a983b477d59.json"}}, {"family": "Parodi L\u00f3pez", "given": "Naldy", "initials": "N", "orcid": "0000-0001-6367-9389", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf3c3c30eee1498d980d3be9bebd0543.json"}}, {"family": "Perj\u00e9s", "given": "\u00c1bel", "initials": "\u00c1", "orcid": "0000-0002-7176-1275", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7cf2b396ec4430c81bc3f76ac2d070b.json"}}, {"family": "Petek", "given": "Davorina", "initials": "D", "orcid": "0000-0002-0151-4463", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb8c599dfe4a496aa21408f3521ded5e.json"}}, {"family": "Petrazzuoli", "given": "Ferdinando", "initials": "F", "orcid": "0000-0003-1058-492X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50bb7fdd235f46629be48fdff0a5fd6c.json"}}, {"family": "Petricek", "given": "Goranka", "initials": "G", "orcid": "0000-0002-6614-3085", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd2203cac86047658296c405e6173680.json"}}, {"family": "Seifert", "given": "Bohumil", "initials": "B", "orcid": "0000-0002-6881-8840", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64e3433f85084d9499b345eb10e31052.json"}}, {"family": "Serafini", "given": "Alice", "initials": "A", "orcid": "0000-0002-7396-2839", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dfd0165d3afe49f49370124c8a379a81.json"}}, {"family": "Sentker", "given": "Theresa", "initials": "T", "orcid": "0000-0003-1162-310X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bed1b751e47d419fa5c1e86a517a8161.json"}}, {"family": "Tiili", "given": "Paula", "initials": "P", "orcid": "0000-0002-7916-7262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3939d43175b4bddbaf87dea226190fb.json"}}, {"family": "Torzsa", "given": "P\u00e9ter", "initials": "P"}, {"family": "Vaes", "given": "Bert", "initials": "B", "orcid": "0000-0001-5244-1930", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e0e264d183c46d198df84a956aef74f.json"}}, {"family": "van Pottebergh", "given": "Gijs", "initials": "G", "orcid": "0000-0002-4189-3517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c5f6c9a7d294faab488ade63d22a9bb.json"}}, {"family": "Vinker", "given": "Shlomo", "initials": "S", "orcid": "0000-0001-9804-7103", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e8d0c73cfe04e4c8ac85f6429cbb8cf.json"}}, {"family": "Astier-Pe\u00f1a", "given": "Mar\u00eda Pilar", "initials": "MP", "orcid": "0000-0002-3192-7672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/585b3e1ed7df4d63b0342ab0d96ef9c4.json"}}, {"family": "G\u00f3mez-Bravo", "given": "Raquel", "initials": "R", "orcid": "0000-0002-3786-8626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa876914ef4c487aa47e1b3248deaab5.json"}}, {"family": "Lingner", "given": "Heidrun", "initials": "H", "orcid": "0000-0003-2074-0367", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49f1b26a486540968df9724abbce2d0a.json"}}, {"family": "Clinical investigators\u2020", "given": "", "initials": ""}, {"family": "Clinical investigators:", "given": "", "initials": ""}], "type": "journal article", "published": "2023-03-21", "journal": {"title": "Eur J Gen Pract", "issn": "1751-1402", "pages": "2182879", "issn-l": null}, "abstract": "Most COVID-19 patients were treated in primary health care (PHC) in Europe.\n\nTo demonstrate the scope of PHC workflow during the COVID-19 pandemic emphasising similarities and differences of patient's clinical pathways in Europe.\n\nDescriptive, cross-sectional study with data acquired through a semi-structured questionnaire in PHC in 30 European countries, created ad hoc and agreed upon among all researchers who participated in the study. GPs from each country answered the approved questionnaire. Main variable: PHC COVID-19 acute clinical pathway. All variables were collected from each country as of September 2020.\n\nCOVID-19 clinics in PHC facilities were organised in 8/30. Case detection and testing were performed in PHC in 27/30 countries. RT-PCR and lateral flow tests were performed in PHC in 23/30, free of charge with a medical prescription. Contact tracing was performed mainly by public health authorities. Mandatory isolation ranged from 5 to 14 days. Sick leave certification was given exclusively by GPs in 21/30 countries. Patient hotels or other resources to isolate patients were available in 12/30. Follow-up to monitor the symptoms and/or new complementary tests was made mainly by phone call (27/30). Chest X-ray and phlebotomy were performed in PHC in 18/30 and 23/30 countries, respectively. Oxygen and low-molecular-weight heparin were available in PHC (21/30).\n\nIn Europe PHC participated in many steps to diagnose, treat and monitor COVID-19 patients. Differences among countries might be addressed at European level for the management of future pandemics.", "doi": "10.1080/13814788.2023.2182879", "pmid": "36943232", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-21T16:07:52.599Z", "modified": "2023-04-21T16:07:53.683Z"}, {"entity": "publication", "iuid": "28cf59f0fd4c4db099e848d6975b0b18", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/28cf59f0fd4c4db099e848d6975b0b18.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/28cf59f0fd4c4db099e848d6975b0b18"}}, "title": "Antiepileptogenesis after Stroke - Trials and Tribulations: Methodological Challenges and Recruitment Results of a Phase II Study with Eslicarbazepine Acetate.", "authors": [{"family": "Koepp", "given": "Matthias J", "initials": "MJ", "orcid": "0000-0002-4277-8000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/862bbdee43044d5594cce53574a38387.json"}}, {"family": "Trinka", "given": "Eugen", "initials": "E", "orcid": "0000-0002-5950-2692", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1618693eb8bf416e8891ab2931877a89.json"}}, {"family": "Mah", "given": "Yee-Haur", "initials": "YH"}, {"family": "Bentes", "given": "Carla", "initials": "C", "orcid": "0000-0003-2399-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/152174fbb79b40f0be4db0ba5a05a5b1.json"}}, {"family": "Knake", "given": "Susanne", "initials": "S"}, {"family": "Gigli", "given": "Gian Luigi", "initials": "GL"}, {"family": "Serratosa", "given": "Jos\u00e9 M", "initials": "JM"}, {"family": "Zelano", "given": "Johan", "initials": "J", "orcid": "0000-0001-9445-4545", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1188e644aaa41c4841cf6acbc1ee11a.json"}}, {"family": "Magalh\u00e3es", "given": "Lu\u00eds M", "initials": "LM"}, {"family": "Pereira", "given": "Ana", "initials": "A"}, {"family": "Moreira", "given": "Joana", "initials": "J"}, {"family": "Soares-da-Silva", "given": "Patr\u00edcio", "initials": "P", "orcid": "0000-0002-2446-5078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59911af4073b40809de32fdb7c104739.json"}}], "type": "journal article", "published": "2023-03-21", "journal": {"title": "Epilepsia Open", "issn": "2470-9239", "issn-l": null}, "abstract": "There is currently no evidence to support the use of antiseizure medications to prevent unprovoked seizures following stroke. Experimental animal models suggested a potential antiepileptogenic effect for eslicarbazepine acetate (ESL), and a Phase II, multicentre, randomised, double-blind, placebo-controlled study was designed to test this hypothesis and assess whether ESL treatment for 1 month can prevent unprovoked seizures following stroke. We outline the design and status of this antiepileptogenesis study, and discuss the challenges encountered in its execution to date. Patients at high risk of developing unprovoked seizures after acute intracerebral haemorrhage or acute ischaemic stroke were randomised to receive ESL 800 mg/day or placebo, initiated within 120 hours after primary stroke occurrence. Treatment continued until Day 30, then tapered off. Patients could receive all necessary therapies for stroke treatment according to clinical practice guidelines and standard of care, and are being followed up for 18 months. The primary efficacy endpoint is occurrence of a first unprovoked seizure within 6 months after randomisation ('failure rate'). Secondary efficacy assessments include occurrence of a first unprovoked seizure during 12 months after randomisation and during the entire study; functional outcomes (Barthel Index original 10-item version; National Institutes of Health Stroke Scale); post-stroke depression (Patient Health Questionnaire-9; PHQ-9); and overall survival. Safety assessments include evaluation of treatment-emergent adverse events; laboratory parameters; vital signs; electrocardiogram; suicidal ideation and behaviour (PHQ-9 question 9). The protocol aimed to randomise approximately 200 patients (1:1), recruited from 21 sites in seven European countries and Israel. Despite the challenges encountered, particularly during the COVID-19 pandemic, the study progressed and included a remarkable number of patients, with 129 screened and 125 randomised. Recruitment was stopped after 30 months, the first patient entered in May 2019, and the study is ongoing and following up on patients according to the Clinical Trial Protocol.", "doi": "10.1002/epi4.12735", "pmid": "36944588", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-21T16:07:35.824Z", "modified": "2023-04-21T16:07:36.005Z"}, {"entity": "publication", "iuid": "f99416f34ecf45aa935971c0406d6b38", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f99416f34ecf45aa935971c0406d6b38.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f99416f34ecf45aa935971c0406d6b38"}}, "title": "The burden of disease due to COVID-19 in Sweden 2020-2021: A disability-adjusted life years (DALYs) study.", "authors": [{"family": "Shedrawy", "given": "Jad", "initials": "J", "orcid": "0000-0002-2700-0727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b9672a195ee45fea4ed03b72e371df4.json"}}, {"family": "Ernst", "given": "Patricia", "initials": "P"}, {"family": "L\u00f6nnroth", "given": "Knut", "initials": "K", "orcid": "0000-0001-6944-0256", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a9b9783181c4e63a6edf4985c1b299d.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2023-03-20", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "14034948231160616", "issn-l": "1403-4948"}, "abstract": "The burden of COVID-19 disease can be measured in terms of disability-adjusted life years (DALYs), which is composed of two components: the years of life lost through premature death (YLL) and the number of years lived with disability (YLD), adjusted for level of disability. This study measured DALYs due to COVID-19 in Sweden and compared it to the burden of other diseases.\n\nThe methodology used in the calculation of DALYs was based on the Global Burden of Disease guidelines. The number of patients diagnosed with mild/moderate, severe or critical COVID-19 and/or post-COVID-19 condition between March 2020 and October 2021 was extracted from national registries and used for YLD calculations. In addition, the numbers of death due to COVID-19 in different age groups were used for the YLL calculation.\n\nDuring the study period, 152,877 DALYs were lost to COVID-19 in Sweden, 99.3% of which was attributed to YLL. Loss of DALYs occurred mainly among the elderly, with 66.8% of DALYs attributed to individuals >70 years old. Compared to other diseases, the burden of COVID-19 in 2020 ranked as the eighth leading cause of DALY lost.\n\nSimilar to other countries, the burden of COVID-19 in Sweden was concentrated mainly among the elderly, who contributed most of the DALY lost due to premature mortality. Yet, DALY loss remained lower for COVID-19 than for several other diseases. The contribution of YLD to DALYs lost was minimal. However empirical data on the occurrence and disability of post-COVID-19 condition are scarce, and YLD may therefore be underestimated.", "doi": "10.1177/14034948231160616", "pmid": "36941820", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10033504"}], "notes": [], "created": "2023-04-21T16:08:06.283Z", "modified": "2023-04-21T16:08:06.349Z"}, {"entity": "publication", "iuid": "b69a5c3107a1457baeb8447e677bdd8d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b69a5c3107a1457baeb8447e677bdd8d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b69a5c3107a1457baeb8447e677bdd8d"}}, "title": "Prevalence of depression among students at a Sri Lankan University: A study using the Patient Health Questionnaire-9 (PHQ-9) during the COVID-19 pandemic.", "authors": [{"family": "Wickramasinghe", "given": "Ayanthi", "initials": "A"}, {"family": "Ess\u00e9n", "given": "Birgitta", "initials": "B"}, {"family": "Surenthirakumaran", "given": "Rajendra", "initials": "R"}, {"family": "Axemo", "given": "Pia", "initials": "P"}], "type": "journal article", "published": "2023-03-20", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "23", "issue": "1", "pages": "528", "issn-l": null}, "abstract": "The prevalence of mental health disorders is known to be high among university students globally. Currently there are only a few studies on depression among university students in Sri Lanka. The aim of this study was to screen for the prevalence of Major Depressive Disorder (MDD) and other forms of depression, and to evaluate the factors associated with MDD.\n\nA cross sectional survey using the Patient Health Questionnaire (PHQ-9) was conducted among 637, second-year students from the faculties of Management Studies & Commerce, Science and Medicine at the University of Jaffna, during the Coronavirus (COVID-19) pandemic. Bivariate associations were assessed using chi-squared tests. Logistic regression was used to evaluate factors associated with any type of ragging.\n\nMDD was considered to have been experienced by 31% of the students. From all three faculties, 70% of the students claimed to have experienced some form of depression ranging from mild to severe. The factor associated with MDD was the students' ethnicity.\n\nDue to the high MDD risk among university students, it is imperative to develop psychosocial interventions to ensure early detection of mental health disorders and provide adequate support to safeguard this vulnerable population.", "doi": "10.1186/s12889-023-15427-y", "pmid": "36941588", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10026232"}, {"db": "pii", "key": "10.1186/s12889-023-15427-y"}], "notes": [], "created": "2023-04-21T16:08:15.824Z", "modified": "2023-04-21T16:08:15.837Z"}, {"entity": "publication", "iuid": "0e2e7e401ebe4519acc47ee41c2dbb0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e2e7e401ebe4519acc47ee41c2dbb0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e2e7e401ebe4519acc47ee41c2dbb0e"}}, "title": "Physical and mental health impact of the COVID-19 pandemic at first year in a Spanish adult cohort.", "authors": [{"family": "Castellvi Obiols", "given": "Pere", "initials": "P", "orcid": "0000-0002-3920-8576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5f47e2d780149d2b28dd7079b83858d.json"}}, {"family": "Miranda-Mendizabal", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3649-7509", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f0dbcee3855458bad3a28364ca06660.json"}}, {"family": "Recoder", "given": "Silvia", "initials": "S", "orcid": "0000-0001-9012-0951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2a5bf86399b4f9db4f65ed751dcba55.json"}}, {"family": "Calbo Sebastian", "given": "Ester", "initials": "E", "orcid": "0000-0001-7750-5347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3002f2d890964d378c40eb3ff608e5fc.json"}}, {"family": "Casajuana-Closas", "given": "Marc", "initials": "M", "orcid": "0000-0001-5653-996X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb15f80de6ee4c859881cf3be4302594.json"}}, {"family": "Leiva", "given": "David", "initials": "D", "orcid": "0000-0003-1314-2588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/130239894726413d964750770b59a970.json"}}, {"family": "Manolov", "given": "Rumen", "initials": "R", "orcid": "0000-0002-9387-1926", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2edbbf5db29d412b9d1201a5abbdedd8.json"}}, {"family": "Matilla-Santander", "given": "Nuria", "initials": "N", "orcid": "0000-0002-5249-102X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a546005ec44e4c1c8ba3bed29bffbb5d.json"}}, {"family": "Lloveras-Bernat", "given": "Isaac", "initials": "I"}, {"family": "Forero", "given": "Carlos G", "initials": "CG", "orcid": "0000-0002-5245-0076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4c978c5182343b880503a902be6b36a.json"}}], "type": "journal article", "published": "2023-03-20", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "13", "issue": "1", "pages": "4547", "issn-l": "2045-2322"}, "abstract": "The COVID-19 pandemic and the political and health measures have profoundly affected the health of our populations. However, very few studies have been published assessing its impact using a prospective cohort. The aim of this study is to describe the impact on physical and mental health due to the COVID-19 pandemic in the general population in Spain, and according to COVID-19 clinical status, during the first year of the pandemic. A longitudinal cohort study with two online surveys were performed on a representative sample of the adult Spanish population before (N = 2005, October/November 2019) and during the pandemic (N = 1357, November/December 2020). We assessed disability using the World Health Organisation Disability Assessment Schedule (WHODAS), major depressive episode (MDE) and suicidal thoughts and behaviours (STB), using an adapted version of the Composite International Diagnostic Interview (CIDI 3.0); generalised anxiety disorder (GAD) using the GAD-7 scale; post-traumatic stress disorder (PTSD) symptoms using the PTSD checklist for DSM-5 (PCL-5). For physical health, there was a statistically significant loss of weight (mean/SD) (T0, 73.22/15.56 vs. T1, 71.21/11.94), less use of tobacco (T0, 11.4% vs. T1, 9.0%) and decreased disability (mean/SD) (T0, 21.52/9.22 vs. T1, 19.03/7.32). For mental health, there was a significant increase in MDE (T0, 6.5% vs. T1, 8.8%) and in the prevalence of GAD (T0, 13.7% vs. T1, 17.7%). The prevalence of STB (T0, 15.1% vs. T1, 7.1%) significantly decreased. Individuals who declared they had been diagnosed with COVID-19 (3.6%) showed a worsening in physical health and an increase in mental health problems and PTSD symptoms. Although suicide risk during the first year of the pandemic was significantly less, many suicide risk factors increased: such as the incidence and persistence of MDE and GAD, the presence of PTSD symptoms in those diagnosed with COVID-19, and a worsening in self-assessed health status. We expect an increase in STB in the population in the long-term. Future research should gather information about the long-term impact of the pandemic.", "doi": "10.1038/s41598-023-28336-2", "pmid": "36941282", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10026238"}, {"db": "pii", "key": "10.1038/s41598-023-28336-2"}], "notes": [], "created": "2023-04-21T16:08:29.984Z", "modified": "2023-04-21T16:08:30.303Z"}, {"entity": "publication", "iuid": "06be7b4ac8c447758d200492540d935c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/06be7b4ac8c447758d200492540d935c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/06be7b4ac8c447758d200492540d935c"}}, "title": "Coping with COVID-19 Pandemic and Sustained Health Behavior: A Cross-Sectional Study in Bangladesh.", "authors": [{"family": "Sizear", "given": "Monaemul Islam", "initials": "MI"}, {"family": "Macassa", "given": "Gloria", "initials": "G", "orcid": "0000-0003-4415-7942", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90dedd73015141c287bc67122ace3764.json"}}, {"family": "Chowdhury", "given": "Mohammad Rocky Khan", "initials": "MRK"}, {"family": "Rashid", "given": "Mamunur", "initials": "M", "orcid": "0000-0001-7558-4168", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f94086e479574c90a4bd63fac5ce70ad.json"}}], "type": "journal article", "published": "2023-03-20", "journal": {"title": "Epidemiologia (Basel)", "issn": "2673-3986", "volume": "4", "issue": "1", "pages": "85-93", "issn-l": null}, "abstract": "During the COVID-19 pandemic, people's health behavioral changes have been transposed into a new dimension. Coping with the COVID-19 pandemic may have an impact on sustained health behavior (SHB). Therefore, this study aimed to explore the validity and reliability of the COVID-19 Coping Scale among working-age individuals and to assess whether coping with COVID-19-related stress could influence SHB in this population. A cross-sectional study was conducted based on the population of the city of Dhaka in Bangladesh. A total of 263 working-age individuals (19-65 years) participated in the study. The present study results confirmed the COVID-19 Coping Scale was a valid and reliable instrument for this population. Moreover, the present finding indicated decreased odds of SHB for individuals who rated lower scores on coping with COVID-19 compared to individuals who rated higher scores; the result remained significant after controlling for gender and education (OR 0.68, 95% CI: 0.54-0.87). The present study suggests two important findings: (i) the instrument used in this study was valid and reliable in this population, and (ii) coping with COVID-19-related stress may be an important aspect of practicing SHB. Policymakers may use the highlighted findings to facilitate sustainable health behavior for long-term health benefits and to tackle future pandemics like COVID-19 or in a similar context.", "doi": "10.3390/epidemiologia4010009", "pmid": "36975617", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10048345"}, {"db": "pii", "key": "epidemiologia4010009"}], "notes": [], "created": "2023-04-21T15:59:19.227Z", "modified": "2023-04-21T15:59:19.323Z"}, {"entity": "publication", "iuid": "ece960f599fd4e9a893444d788d8dbdc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ece960f599fd4e9a893444d788d8dbdc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ece960f599fd4e9a893444d788d8dbdc"}}, "title": "Computerization of the Work of General Practitioners: Mixed Methods Survey of Final-Year Medical Students in Ireland.", "authors": [{"family": "Blease", "given": "Charlotte", "initials": "C", "orcid": "0000-0003-3657-2476", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af05b93e66b34265808f33799070ef16.json"}}, {"family": "Kharko", "given": "Anna", "initials": "A", "orcid": "0000-0003-0908-6173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a367f676bc334b7fbdcae307d5e292a2.json"}}, {"family": "Bernstein", "given": "Michael", "initials": "M", "orcid": "0000-0001-7221-0697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe1a4546ab09474c97096de65036f69a.json"}}, {"family": "Bradley", "given": "Colin", "initials": "C", "orcid": "0000-0002-3595-9567", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61ed23f766504570b950289fc569f806.json"}}, {"family": "Houston", "given": "Muiris", "initials": "M", "orcid": "0000-0003-4124-8523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce99d9a5ea2c474bb6185c69ff21ffdc.json"}}, {"family": "Walsh", "given": "Ian", "initials": "I", "orcid": "0000-0002-3750-2499", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c81f5124483a41b5b4b87fb60875bba6.json"}}, {"family": "D Mandl", "given": "Kenneth", "initials": "K", "orcid": "0000-0002-9781-0477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4fb859839a7d46eb963d58e8fa0cab58.json"}}], "type": "journal article", "published": "2023-03-20", "journal": {"title": "JMIR Med Educ", "issn": "2369-3762", "volume": "9", "pages": "e42639", "issn-l": null}, "abstract": "The potential for digital health technologies, including machine learning (ML)-enabled tools, to disrupt the medical profession is the subject of ongoing debate within biomedical informatics.\n\nWe aimed to describe the opinions of final-year medical students in Ireland regarding the potential of future technology to replace or work alongside general practitioners (GPs) in performing key tasks.\n\nBetween March 2019 and April 2020, using a convenience sample, we conducted a mixed methods paper-based survey of final-year medical students. The survey was administered at 4 out of 7 medical schools in Ireland across each of the 4 provinces in the country. Quantitative data were analyzed using descriptive statistics and nonparametric tests. We used thematic content analysis to investigate free-text responses.\n\nIn total, 43.1% (252/585) of the final-year students at 3 medical schools responded, and data collection at 1 medical school was terminated due to disruptions associated with the COVID-19 pandemic. With regard to forecasting the potential impact of artificial intelligence (AI)/ML on primary care 25 years from now, around half (127/246, 51.6%) of all surveyed students believed the work of GPs will change minimally or not at all. Notably, students who did not intend to enter primary care predicted that AI/ML will have a great impact on the work of GPs.\n\nWe caution that without a firm curricular foundation on advances in AI/ML, students may rely on extreme perspectives involving self-preserving optimism biases that demote the impact of advances in technology on primary care on the one hand and technohype on the other. Ultimately, these biases may lead to negative consequences in health care. Improvements in medical education could help prepare tomorrow's doctors to optimize and lead the ethical and evidence-based implementation of AI/ML-enabled tools in medicine for enhancing the care of tomorrow's patients.", "doi": "10.2196/42639", "pmid": "36939809", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "v9i1e42639"}], "notes": [], "created": "2023-04-21T16:09:17.739Z", "modified": "2023-04-21T16:09:17.978Z"}, {"entity": "publication", "iuid": "c36f8f54506f4c818e2bf18f5a4a6a80", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c36f8f54506f4c818e2bf18f5a4a6a80.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c36f8f54506f4c818e2bf18f5a4a6a80"}}, "title": "Vulval Aphthous Ulcers in Adolescents Following COVID-19 Vaccination - Analysis of an international case series.", "authors": [{"family": "Rudolph", "given": "Annette", "initials": "A"}, {"family": "Savage", "given": "Dr Ruth", "initials": "DR"}], "type": "journal article", "published": "2023-03-17", "journal": {"title": "J Pediatr Adolesc Gynecol", "issn": "1873-4332", "issn-l": null}, "abstract": "To review and characterise reports of vulval aphthous ulcers (VAU) following COVID-19 vaccination in VigiBase, the World Health Organization global database of reported potential side effects of medicinal products, to demonstrate the importance and power of case reports for rare suspected adverse reactions and to investigate whether they suggest a potential for COVID-19 vaccination to be a trigger.\n\nCases reporting the Medical Dictionary for Regulatory Activities' (MedDRA) Preferred Term (PT) \"Vulvovaginal ulceration\" and related PTs in adolescent patients aged 12 to 17 years in association with any COVID-19 vaccine were extracted from VigiBase. The cases were clinically reviewed, and causality was assessed by applying the Bradford Hill criteria to the obtained case series.\n\nAs of June 30th, 2022, there were 444 reports for the selected MedDRA PTs following COVID-19 vaccination in VigiBase. Ninety-four de-duplicated reports concerned adolescent female patients. Thirty-seven cases were clinically consistent with the diagnosis of VAU. Upon causality assessment, the analysed case series fulfilled six of the nine Austen Bradford Hill criteria supporting a potential causal relationship.\n\nVAU can be perceived as a traumatic experience, especially in adolescent patients. There is, furthermore, a risk that the ulcers will be misdiagnosed resulting in avoidable investigation and treatment burdens for patients. We communicate our findings to support the small number of published case reports and raise awareness of VAU occurring in a temporal association with COVID-19 vaccination. Furthermore, our analysis supports observations about the value of case reports for the recognition and assessment of rare adverse events.", "doi": "10.1016/j.jpag.2023.03.006", "pmid": "36934803", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10020135"}, {"db": "pii", "key": "S1083-3188(23)00311-X"}], "notes": [], "created": "2023-04-21T16:11:18.536Z", "modified": "2023-04-21T16:11:18.564Z"}, {"entity": "publication", "iuid": "1a0d84990b34405eabcad32112e03176", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1a0d84990b34405eabcad32112e03176.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1a0d84990b34405eabcad32112e03176"}}, "title": "Severe COVID-19 during pregnancy in Sweden, Norway, and Denmark.", "authors": [{"family": "\u00d6rtqvist", "given": "Anne K", "initials": "AK", "orcid": "0000-0001-9019-9233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7bfdbeb2a2d848ec928a6c7f7d112465.json"}}, {"family": "Magnus", "given": "Maria C", "initials": "MC", "orcid": "0000-0002-0568-3774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3530918cfd534021a45a80628c89c580.json"}}, {"family": "Aabakke", "given": "Anna J M", "initials": "AJM", "orcid": "0000-0003-4754-506X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c142bd2b1fc84a7e864d2af58096bcaf.json"}}, {"family": "Urhoj", "given": "Stine Kjaer", "initials": "SK", "orcid": "0000-0002-2069-9723", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b924cc03db2b4fffbb075e2d7e3579ac.json"}}, {"family": "Vinkel Hansen", "given": "Anne", "initials": "A", "orcid": "0000-0003-4523-3521", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7045d9cc7a814e718d962615eebe0a1a.json"}}, {"family": "Nybo Andersen", "given": "Anne-Marie", "initials": "AM"}, {"family": "Krebs", "given": "Lone", "initials": "L", "orcid": "0000-0001-5433-4776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1efab04a970448494fc2e06bfa3a55c.json"}}, {"family": "Pettersson", "given": "Karin", "initials": "K"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE", "orcid": "0000-0002-2199-5225", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eaa51eb1c42a4b12b21b248e363fbf04.json"}}, {"family": "Stephansson", "given": "Olof", "initials": "O", "orcid": "0000-0003-1528-4563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39af50356a574c80ba6bd2227ecb5cf5.json"}}], "type": "journal article", "published": "2023-03-17", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "issn-l": "0001-6349"}, "abstract": "Pregnancy is a risk factor for severe coronavirus disease 2019 (COVID-19) and adverse pregnancy outcomes. We aimed to explore maternal characteristics, pregnancy outcomes, vaccination status, and virus variants among pregnant women admitted to intensive care units (ICU) with severe COVID-19.\n\nWe identified pregnant women admitted to ICU in Sweden (n = 96), Norway (n = 31), and Denmark (n = 16) because of severe COVID-19, from national registers and clinical databases between March 2020 and February 2022 (Denmark), August 2022 (Sweden), or December 2022 (Norway). Their background characteristics, pregnancy outcome, and vaccination status were compared with all birthing women and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test-positive pregnant women during the same time period. We calculated the number admitted to ICU per 10 000 birthing and per 1000 SARS-CoV-2 test-positive women during the Index, Alpha, Delta, and Omicron periods.\n\nWomen admitted to ICU had a higher mean body mass index, were more often of non-Scandinavian origin, had on average lower education and income levels, had a higher proportion of chronic and pregnancy-related conditions, delivered preterm, had neonates with low Apgar scores, and had more infants admitted to neonatal care, compared with all birthing and test-positive pregnant women. Of those admitted to ICU, only 7% had been vaccinated before admission. Overall, the highest proportion of women admitted to ICU per birthing was during the Delta period (4.1 per 10 000 birthing women). In Norway, the highest proportion admitted to ICU per test-positive pregnant women was during the Delta period (17.8 per 1000 test-positive), whereas the highest proportion of admitted per test-positive in Sweden and Denmark was seen during the Index period (15.4 and 8.9 per 1000 test-positive, respectively).\n\nAdmission to ICU because of COVID-19 in pregnancy was a rare event in the Scandinavian countries, but women who were unvaccinated, of non-Scandinavian origin, and with lower socio-economic status were at higher risk of admission to ICU. In addition, women admitted to ICU for COVID-19 had higher risk of adverse pregnancy outcomes.", "doi": "10.1111/aogs.14552", "pmid": "36928990", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-21T16:12:18.383Z", "modified": "2023-04-21T16:12:18.648Z"}, {"entity": "publication", "iuid": "86b59b89448646ff8a5c908dc1d5c06d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86b59b89448646ff8a5c908dc1d5c06d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86b59b89448646ff8a5c908dc1d5c06d"}}, "title": "Correction: Study protocol for a randomized controlled trial evaluating the effectiveness of an internet-based self-help intervention to cope with psychological distress due to COVID-19 in the Italian general population: the RinasciMENTE project.", "authors": [{"family": "Bertuzzi", "given": "Vanessa", "initials": "V", "orcid": "0000-0002-8541-5357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7abc069e75034b0e96265c7d48fb95a2.json"}}, {"family": "Semonella", "given": "Michelle", "initials": "M"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Manzoni", "given": "Gian Mauro", "initials": "GM"}, {"family": "Castelnuovo", "given": "Gianluca", "initials": "G"}, {"family": "Molinari", "given": "Enrico", "initials": "E"}, {"family": "Pietrabissa", "given": "Giada", "initials": "G"}], "type": "published erratum", "published": "2023-03-17", "journal": {"title": "Trials", "issn": "1745-6215", "volume": "24", "issue": "1", "pages": "201", "issn-l": null}, "abstract": null, "doi": "10.1186/s13063-023-07217-z", "pmid": "36932452", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10022985"}, {"db": "pii", "key": "10.1186/s13063-023-07217-z"}], "notes": [], "created": "2023-04-21T16:12:08.811Z", "modified": "2023-04-21T16:12:08.820Z"}, {"entity": "publication", "iuid": "c2ec02b31430403383952bf3cb8e1445", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2ec02b31430403383952bf3cb8e1445.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2ec02b31430403383952bf3cb8e1445"}}, "title": "Life Satisfaction among Self-Employed People in Different Welfare Regimes during the COVID-19 Pandemic: Significance of Household Finances and Concerns about Work.", "authors": [{"family": "Nordenmark", "given": "Mikael", "initials": "M"}, {"family": "Landstad", "given": "Bodil J", "initials": "BJ", "orcid": "0000-0001-6558-3129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bdb9f75451d4f2b8c87a8f8a837a09d.json"}}, {"family": "Tjulin", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Vinberg", "given": "Stig", "initials": "S", "orcid": "0000-0002-5935-5688", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c63c4ca58d242d18741dba0b0af5afb.json"}}], "type": "journal article", "published": "2023-03-15", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "20", "issue": "6", "issn-l": null}, "abstract": "Most studies have shown that self-employed people have higher levels of life satisfaction than employed people due to high levels of job satisfaction, work flexibility, and job control. However, during the COVID-19 pandemic, many self-employed people experienced economic strain and worried about the situation of their employees and survival of the company. The aim of this study was to examine the level of life satisfaction among self-employed people during the COVID-19 pandemic in different welfare regimes. Analyses were mainly based on Eurofound's \"Living, Working and COVID-19\" online survey. Fieldwork took place between April and June 2020 in 27 EU countries. The results showed that there was a significantly lower level of life satisfaction among self-employed people than employed people during the pandemic. This was in contrast to analyses from approximately one year before the pandemic, which showed that life satisfaction was higher among self-employed people. The main reasons for this lower level of life satisfaction among the self-employed during the pandemic were worse household financial situation and more worries about their job. Analyses of life satisfaction among the self-employed in different welfare regimes indicated that self-employed people in the Nordic welfare state regime largely kept their relatively high level of life satisfaction during the pandemic, but this was not the case for self-employed people in other welfare regimes.", "doi": "10.3390/ijerph20065141", "pmid": "36982050", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10049569"}, {"db": "pii", "key": "ijerph20065141"}], "notes": [], "created": "2023-04-21T15:57:00.390Z", "modified": "2023-04-21T15:57:50.063Z"}, {"entity": "publication", "iuid": "2b48e1851208422999e1cae7b9e92800", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b48e1851208422999e1cae7b9e92800.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b48e1851208422999e1cae7b9e92800"}}, "title": "COVID-19 and income inequality: evidence from monthly population registers.", "authors": [{"family": "Angelov", "given": "Nikolay", "initials": "N"}, {"family": "Waldenstr\u00f6m", "given": "Daniel", "initials": "D", "orcid": "0000-0002-0940-2466", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1941a15d28f44dc8f42615088795534.json"}}], "type": "journal article", "published": "2023-03-15", "journal": {"title": "J Econ Inequal", "issn": "1569-1721", "issn-l": null, "volume": null, "issue": null, "pages": "1-29"}, "abstract": "We measure the distributional impact of the COVID-19 pandemic using newly released population register data in Sweden. Monthly earnings inequality increased during the pandemic, and the key driver is income losses among low-paid individuals while middle- and high-income earners were almost unaffected. In terms of employment, as measured by having positive monthly earnings, the pandemic had a larger negative impact on private-sector workers and on women. In terms of earnings conditional on being employed, the effect was still more negative for women, but less negative for private-sector workers compared to publicly employed. Using data on individual take-up of government COVID-19 support, we show that policy significantly dampened the inequality increase, but did not fully offset it. Annual total market income inequality, which also includes capital income and taxable transfers, shows similar patterns of increasing inequality during the pandemic.\r\n\r\nThe online version contains supplementary material available at 10.1007/s10888-022-09560-8.", "doi": "10.1007/s10888-022-09560-8", "pmid": "37360569", "labels": {"Category: Public Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10015130"}, {"db": "pii", "key": "9560"}], "notes": [], "created": "2023-10-04T09:31:51.035Z", "modified": "2023-10-04T10:56:21.962Z"}, {"entity": "publication", "iuid": "87617a1379e04fb7aa3b32595d1bc9d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87617a1379e04fb7aa3b32595d1bc9d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87617a1379e04fb7aa3b32595d1bc9d9"}}, "title": "Recruitment of Adolescent Young Carers to a Psychosocial Support Intervention Study in Six European Countries: Lessons Learned from the ME-WE Project.", "authors": [{"family": "Barbabella", "given": "Francesco", "initials": "F"}, {"family": "Magnusson", "given": "Lennart", "initials": "L"}, {"family": "Boccaletti", "given": "Licia", "initials": "L"}, {"family": "Casu", "given": "Giulia", "initials": "G", "orcid": "0000-0001-5441-3044", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7cd6e9e8122e40fb8aa1fd15dff39c9f.json"}}, {"family": "Hlebec", "given": "Valentina", "initials": "V"}, {"family": "Bolko", "given": "Irena", "initials": "I"}, {"family": "Lewis", "given": "Feylyn", "initials": "F", "orcid": "0000-0003-2306-8182", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35b1b33cf19e44a895362c21b4184b08.json"}}, {"family": "Hoefman", "given": "Renske", "initials": "R", "orcid": "0000-0003-4533-2562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/979bca9baba2402e8c03397c113d9bd2.json"}}, {"family": "Brolin", "given": "Rosita", "initials": "R"}, {"family": "Santini", "given": "Sara", "initials": "S", "orcid": "0000-0003-4705-4631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0b2248297e14350917aa7ec610d87f4.json"}}, {"family": "Socci", "given": "Marco", "initials": "M", "orcid": "0000-0001-9093-2167", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff1725877f3344b9bfa11c4fafa40e9d.json"}}, {"family": "D'Amen", "given": "Barbara", "initials": "B", "orcid": "0000-0002-8986-5216", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ccb20d6201a47d887799947d62154b3.json"}}, {"family": "de Jong", "given": "Yvonne", "initials": "Y"}, {"family": "Bouwman", "given": "Tamara", "initials": "T"}, {"family": "de Jong", "given": "Nynke", "initials": "N"}, {"family": "Leu", "given": "Agnes", "initials": "A", "orcid": "0000-0002-5451-837X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e084dede367e4310bdfd006ad84499eb.json"}}, {"family": "Phelps", "given": "Daniel", "initials": "D"}, {"family": "Guggiari", "given": "Elena", "initials": "E", "orcid": "0000-0002-8656-9825", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc16e1d387114fc482d40dd5be7e89d9.json"}}, {"family": "Wirth", "given": "Alexandra", "initials": "A"}, {"family": "Morgan", "given": "Vicky", "initials": "V"}, {"family": "Becker", "given": "Saul", "initials": "S"}, {"family": "Hanson", "given": "Elizabeth", "initials": "E", "orcid": "0000-0001-7609-4822", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1652497e6384360bc8c55d2670be4a9.json"}}], "type": "randomized controlled trial", "published": "2023-03-14", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "20", "issue": "6", "issn-l": null}, "abstract": "Young carers provide a substantial amount of care to family members and support to friends, yet their situation has not been actively addressed in research and policy in many European countries or indeed globally. Awareness of their situation by professionals and among children and young carers themselves remains low overall. Thus, young carers remain a largely hidden group within society. This study reports and analyses the recruitment process in a multi-centre intervention study offering psychosocial support to adolescent young carers (AYCs) aged 15-17 years. A cluster-randomised controlled trial was designed, with recruitment taking place in Italy, the Netherlands, Slovenia, Sweden, Switzerland and the United Kingdom exploiting various channels, including partnerships with schools, health and social services and carers organisations. In total, 478 AYCs were recruited and, after screening failures, withdrawals and initial dropouts, 217 were enrolled and started the intervention. Challenges encountered in reaching, recruiting and retaining AYCs included low levels of awareness among AYCs, a low willingness to participate in study activities, uncertainty about the prevalence of AYCs, a limited school capacity to support the recruitment; COVID-19 spreading in 2020-2021 and related restrictions. Based on this experience, recommendations are put forward for how to better engage AYCs in research.", "doi": "10.3390/ijerph20065074", "pmid": "36981983", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10049644"}, {"db": "pii", "key": "ijerph20065074"}], "notes": [], "created": "2023-04-21T15:58:06.553Z", "modified": "2023-04-21T15:58:06.801Z"}, {"entity": "publication", "iuid": "39efdd3d431f44b8bea54043da5f5f6d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/39efdd3d431f44b8bea54043da5f5f6d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/39efdd3d431f44b8bea54043da5f5f6d"}}, "title": "The COVID-19 endemic in Vietnam: Contextual considerations and implications.", "authors": [{"family": "Doan", "given": "Linh Phuong", "initials": "LP"}, {"family": "Le Vu", "given": "Minh Ngoc", "initials": "MN"}, {"family": "Vu", "given": "Giang Thu", "initials": "GT"}, {"family": "Le", "given": "Huong Thi", "initials": "HT"}, {"family": "Nguyen", "given": "Long Hoang", "initials": "LH"}, {"family": "Latkin", "given": "Carl A", "initials": "CA"}, {"family": "Ho", "given": "Roger C M", "initials": "RCM"}], "type": "journal article", "published": "2023-03-13", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "11", "pages": "997635", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2023.997635", "pmid": "36992873", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10040746"}], "notes": [], "created": "2023-04-21T15:55:27.197Z", "modified": "2023-04-21T15:55:27.201Z"}, {"entity": "publication", "iuid": "10e18b6f1cc6468784325fed2801dbcf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/10e18b6f1cc6468784325fed2801dbcf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/10e18b6f1cc6468784325fed2801dbcf"}}, "title": "NK cells in COVID-19 - from disease to vaccination.", "authors": [{"family": "Hammer", "given": "Quirin", "initials": "Q"}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Bister", "given": "Jonna", "initials": "J"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4691d38f3268433696d7c65ea235a12b.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}], "type": "journal article", "published": "2023-03-11", "journal": {"title": "J Leukoc Biol", "issn": "1938-3673", "issn-l": null}, "abstract": "Natural killer (NK) cells participate in the host innate immune response to viral infection. Conversely, NK cell dysfunction and hyperactivation can contribute to tissue damage and immunopathology. Here, we review recent studies with respect to NK cell activity during infection with human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Discussed are initial reports of patients hospitalized with coronavirus disease 2019 (COVID-19), which revealed prompt NK cell activation during the acute disease state. Another hallmark of COVID-19, early on observed, was a decrease in numbers of NK cells in the circulation. Data from patients with acute SARS-CoV-2 infection as well as from in vitro models demonstrated strong anti-SARS-CoV-2 activity by NK cells, likely through direct cytotoxicity as well as indirectly by secreting cytokines. Additionally, we describe the molecular mechanisms underlying NK cell recognition of SARS-CoV-2 infected cells, which involve triggering of multiple activating receptors including NKG2D as well as loss-of-inhibition through NKG2A. Discussed is also the ability of NK cells to respond to SARS-CoV-2 infection via antibody dependent cellular cytotoxicity. With the respect to NK cells in the pathogenesis of COVID-19, we review studies demonstrating how hyperactivation and misdirected NK cell responses could contribute to disease course. Finally, while knowledge is still rather limited, we discuss current insights suggesting a contribution of an early NK cell activation-response in the generation of immunity against SARS-CoV-2 following vaccination an anti-SARS-CoV-2 mRNA vaccines.", "doi": "10.1093/jleuko/qiad031", "pmid": "36976012", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7076154"}], "notes": [], "created": "2023-04-21T15:59:08.245Z", "modified": "2023-04-21T15:59:08.257Z"}, {"entity": "publication", "iuid": "01c42b267cba4509987e4de5e9f89818", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01c42b267cba4509987e4de5e9f89818.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01c42b267cba4509987e4de5e9f89818"}}, "title": "COVID-19 and unfavorable changes in mental health unrelated to changes in physical activity, sedentary time, and health behaviors among Swedish adolescents: A longitudinal study.", "authors": [{"family": "Nyberg", "given": "Gisela", "initials": "G"}, {"family": "Helgad\u00f3ttir", "given": "Bj\u00f6rg", "initials": "B"}, {"family": "Kjellenberg", "given": "Karin", "initials": "K"}, {"family": "Ekblom", "given": "\u00d6rjan", "initials": "\u00d6"}], "type": "journal article", "published": "2023-03-10", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "11", "pages": "1115789", "issn-l": "2296-2565"}, "abstract": "The COVID-19 pandemic has had major impact on the daily lives of adolescents. This study examined whether mental health outcomes had changed over the pandemic, and if such changes were related to changes in physical activity (PA), sedentary time, sleep, screen time, and participation in organized sports.\n\nIn this longitudinal study, data were collected in autumn 2019 with follow-up measurements in spring 2021. In total, 558 schools were invited and 34 schools around Stockholm with a variation in socioeconomic background were included. Physical activity and sedentary time were measured for seven consecutive days by accelerometry (Actigraph). Anxiety, health-related quality of life (HRQoL), psychosomatic health, stress, sleep duration, screen time, and organized sports participation were self-reported in questionnaires. Linear models were applied to estimate associations between changes in mental health outcomes and exposures.\n\nFrom the baseline sample of 1,139 participants, 585 (55% girls), mean (SD) age 14.9 (0.3) years, participated in the follow-up. Between 2019 and 2021, there was a decrease in HRQoL [mean difference -1.7 (-2.3, -1.2), p < 0.001], increase in psychosomatic health problems [mean difference 1.8 (1.3, 2.3), p < 0.001], and an increase in the number of participants with high stress [from 94 (28%) to 139 (42%), p < 0.001]. Weekly light PA and sleep duration decreased and weekly sedentary time and screen time increased unrelated to changes in mental health outcomes. An increase in sleep duration during weekdays was significantly related to both a decrease in anxiety (B = -0.71, CI: -1.36, -0.06) and an increase in HRQoL (B = 1.00, CI: 0.51, 1.49).\n\nDuring the COVID-19 pandemic, mental health appears to have been impaired in Swedish adolescents, but unrelated to changes in PA, sedentary time, screen time, or participation in organized sports. However, increased sleep duration on weekdays was related to less anxiety and better HRQoL. The results may help policy makers and other stakeholders comprehend the differential effects of the COVID-19 pandemic on mental health outcomes and help guiding the planning of policy actions.\n\nISRCTN15689873.", "doi": "10.3389/fpubh.2023.1115789", "pmid": "36969680", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10036362"}, {"db": "ISRCTN", "key": "ISRCTN15689873"}], "notes": [], "created": "2023-04-21T16:02:18.488Z", "modified": "2023-04-21T16:02:18.493Z"}, {"entity": "publication", "iuid": "fd9ca1a78b3a4cc8aefa609060b3984a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fd9ca1a78b3a4cc8aefa609060b3984a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fd9ca1a78b3a4cc8aefa609060b3984a"}}, "title": "Living through a Global Pandemic: A Cross-Sectional Study on the Psychological Resilience of the University Population in Iran.", "authors": [{"family": "Ahmadi", "given": "Fereshteh", "initials": "F", "orcid": "0000-0002-8823-6434", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f4f676633f24637b135c494dcb33cc9.json"}}, {"family": "Cetrez", "given": "\u00d6nver Andreas", "initials": "\u00d6A", "orcid": "0000-0001-6274-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3070dcb6e8234c9b973573f7172e7821.json"}}, {"family": "Zandi", "given": "Saeid", "initials": "S", "orcid": "0000-0003-1272-7170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a941295613dc468e8282c9f8f157a4b6.json"}}], "type": "journal article", "published": "2023-03-09", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "20", "issue": "6", "issn-l": null}, "abstract": "This study aimed to describe and understand the individual and social dimensions of resiliency among Iranian academics as professionals during the early wave of the ongoing pandemic. Furthermore, we aimed to emphasize the cultural context in our analysis.\n\nA cross-sectional survey design was adopted. We used convenient sampling, administered through an online survey, among academics at Iranian universities (n = 196, 75% women). We employed the CD-RISC 2 instrument, items on life meaning, and a modified version of Pargament's RCOPE instrument (Meaning, Control, Comfort/Spirituality, Intimacy/Spirituality, and Life Transformation).\n\nThe results revealed a strong level of resilience among men (M = 5.78) and women (M = 5.52). Self-rated health was rated as excellent, very good, or good among a majority (92%) of the participants, more so among men. Family was one of the factors that most strongly gave life meaning, followed by friends, work/school, and religion/spirituality. There was a strong correlation between self-rated health and life as part of a greater whole, being alone, and listening to the sounds of the surrounding nature.\n\nBoth personal and social levels of resilience and meaning-making are seen in the results, with an ability to balance between obstacles and resources. Cultural practices are interdependent, which also include the individual and social dimensions of resiliency and meaning-making.", "doi": "10.3390/ijerph20064844", "pmid": "36981752", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10049328"}, {"db": "pii", "key": "ijerph20064844"}], "notes": [], "created": "2023-04-21T15:58:20.899Z", "modified": "2023-04-21T15:58:20.975Z"}, {"entity": "publication", "iuid": "634c2fd0451c41c980c396b1199b3036", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/634c2fd0451c41c980c396b1199b3036.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/634c2fd0451c41c980c396b1199b3036"}}, "title": "Editorial: Medication safety in COVID-19 management, Volume II.", "authors": [{"family": "Das", "given": "Saibal", "initials": "S"}], "type": "editorial", "published": "2023-03-09", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "14", "pages": "1175152", "issn-l": "1663-9812"}, "abstract": null, "doi": "10.3389/fphar.2023.1175152", "pmid": "36969864", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10034399"}, {"db": "pii", "key": "1175152"}], "notes": [], "created": "2023-04-21T16:01:34.408Z", "modified": "2023-04-21T16:01:42.674Z"}, {"entity": "publication", "iuid": "8a242d597bec44148573ceb5c9f65abf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a242d597bec44148573ceb5c9f65abf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a242d597bec44148573ceb5c9f65abf"}}, "title": "\"Having vaccines is good but not enough\": Requirements for optimal COVID-19 immunization program in Vietnam.", "authors": [{"family": "Doan", "given": "Linh Phuong", "initials": "LP"}, {"family": "Dao", "given": "Nam Gia", "initials": "NG"}, {"family": "Nguyen", "given": "Duy Cao", "initials": "DC"}, {"family": "Dang", "given": "Trang Huyen Thi", "initials": "THT"}, {"family": "Vu", "given": "Giang Thu", "initials": "GT"}, {"family": "Nguyen", "given": "Long Hoang", "initials": "LH"}, {"family": "Vu", "given": "Linh Gia", "initials": "LG"}, {"family": "Le", "given": "Huong Thi", "initials": "HT"}, {"family": "Latkin", "given": "Carl A", "initials": "CA"}, {"family": "Ho", "given": "Cyrus S H", "initials": "CSH"}, {"family": "Ho", "given": "Roger C M", "initials": "RCM"}], "type": "journal article", "published": "2023-03-09", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "11", "pages": "1137401", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2023.1137401", "pmid": "36969663", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10033707"}], "notes": [], "created": "2023-04-21T16:02:31.008Z", "modified": "2023-04-21T16:02:31.022Z"}, {"entity": "publication", "iuid": "5abea92c910c4db68a4228c66e465a01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5abea92c910c4db68a4228c66e465a01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5abea92c910c4db68a4228c66e465a01"}}, "title": "Understanding the impact of the COVID\u201119 pandemic on healthcare services for adults during three waves of COVID\u201119 infections: A South African private sector experience.", "authors": [{"family": "Nematswerani", "given": "N", "initials": "N"}, {"family": "Steenkamp", "given": "L", "initials": "L"}, {"family": "Haneef", "given": "S", "initials": "S"}, {"family": "Naidoo", "given": "R M", "initials": "RM"}, {"family": "Fonn", "given": "S", "initials": "S"}], "type": "journal article", "published": "2023-03-08", "journal": {"title": "S Afr Med J", "issn": "2078-5135", "issn-l": null, "volume": "113", "issue": "4", "pages": "e16505"}, "abstract": "Since the onset of the COVID\u201119 pandemic, healthcare resources have been repurposed to focus on COVID\u201119. Resource reallocation and restrictions to movement that affected general access to care may have inadvertently resulted in undue disruptions in the continuum of care for patients requiring non-COVID\u201119 healthcare services.\r\n\r\nTo describe the change in pattern of health service use in the South African (SA) private sector.\r\n\r\nWe conducted a retrospective study of a nationwide cohort of privately insured individuals. An analysis of claims data was performed for non-COVID\u201119 related healthcare services provided from April 2020 to December 2020 (year 1 of COVID\u201119) and April 2021 to December 2021 (year 2 of COVID\u201119) relative to the same period in 2019 prior to the COVID\u201119 pandemic in SA. Over and above plotting the monthly trends, we tested for statistical significance of the changes using a Wilcoxon test given the non-normality of all the outcomes.\r\n\r\nBetween April and December 2020, relative to the same period in 2021, and also relative to the same period in 2019, we found a 31.9% (p<0.01) and a 16.6% (p<0.01) reduction in emergency room visits, respectively; a 35.9% (p<0.01) and 20.5% (p<0.01) reduction in medical hospital admissions; a 27.4% (p=0.01) and 13.0% (p=0.03) reduction in surgical hospital admissions; a 14.5% (p<0.01) and 4.1% (p=0.16) reduction in face-to-face general practitioner consultations for chronic members; a 24.9% (p=0.06) and 5.2% (p=0.54) reduction in mammography for female members; a 23.4% (p=0.03) and 10.8% (p=0.09) reduction in Pap smear screenings for female members; a 16.5% (p=0.08) and 12.1% (p=0.27) reduction in colorectal cancer registrations and an 18.2% (p=0.08) and 8.9% (p=0.07) decrease in all oncology diagnoses. Uptake of telehealth services throughout the healthcare delivery system increased by 5 708% in 2020 compared with 2019, and 36.1% for 2021 compared with 2020.\r\n\r\nA significant reduction in emergency room visits, hospital admissions and utilisation of primary care services was observed since the start of the pandemic. Further research is required to understand if there are long-term consequences of delayed care. An increase in the use of digital consultations was observed. Research on their acceptability and effectiveness may open new modalities of care, which may have cost- and time-saving benefits.", "doi": "10.7196/SAMJ.2023.v113i4.16505", "pmid": "37283155", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:31:48.559Z", "modified": "2023-10-04T10:55:10.601Z"}, {"entity": "publication", "iuid": "b181239c838c4757a71db6e6435ea230", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b181239c838c4757a71db6e6435ea230.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b181239c838c4757a71db6e6435ea230"}}, "title": "Improved outcomes over time and higher mortality in CMV seropositive allogeneic stem cell transplantation patients with COVID-19; An infectious disease working party study from the European Society for Blood and Marrow Transplantation registry.", "authors": [{"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Tridello", "given": "Gloria", "initials": "G"}, {"family": "Pi\u00f1ana", "given": "Jose Luis", "initials": "JL"}, {"family": "Ciceri", "given": "Fabio", "initials": "F"}, {"family": "Sengeloev", "given": "Henrik", "initials": "H"}, {"family": "Kulagin", "given": "Alexander", "initials": "A"}, {"family": "Mielke", "given": "Stephan", "initials": "S"}, {"family": "Yegin", "given": "Zeynep Arzu", "initials": "ZA"}, {"family": "Collin", "given": "Matthew", "initials": "M"}, {"family": "Einardottir", "given": "Sigrun", "initials": "S"}, {"family": "Lepretre", "given": "Sophie Ducastelle", "initials": "SD"}, {"family": "Maertens", "given": "Johan", "initials": "J"}, {"family": "Campos", "given": "Antonio", "initials": "A"}, {"family": "Metafuni", "given": "Elisabetta", "initials": "E"}, {"family": "Pichler", "given": "Herbert", "initials": "H"}, {"family": "Folber", "given": "Frantisek", "initials": "F"}, {"family": "Solano", "given": "Carlos", "initials": "C"}, {"family": "Nicholson", "given": "Emma", "initials": "E"}, {"family": "Y\u00fcksel", "given": "Meltem Kurt", "initials": "MK"}, {"family": "Carlson", "given": "Kristina", "initials": "K"}, {"family": "Aguado", "given": "Beatriz", "initials": "B"}, {"family": "Besley", "given": "Caroline", "initials": "C"}, {"family": "Byrne", "given": "Jenny", "initials": "J"}, {"family": "Heras", "given": "Immaculada", "initials": "I"}, {"family": "Dignan", "given": "Fiona", "initials": "F"}, {"family": "Kr\u00f6ger", "given": "Nicolaus", "initials": "N"}, {"family": "Robin", "given": "Christine", "initials": "C"}, {"family": "Khan", "given": "Anjum", "initials": "A"}, {"family": "Lenhoff", "given": "Stig", "initials": "S"}, {"family": "Grassi", "given": "Anna", "initials": "A"}, {"family": "Dobsinska", "given": "Veronika", "initials": "V"}, {"family": "Miranda", "given": "Nuno", "initials": "N"}, {"family": "Jimenez", "given": "Maria-Jose", "initials": "MJ"}, {"family": "Yonal-Hindilerden", "given": "Ipek", "initials": "I"}, {"family": "Wilson", "given": "Keith", "initials": "K"}, {"family": "Averbuch", "given": "Dina", "initials": "D"}, {"family": "Cesaro", "given": "Simone", "initials": "S"}, {"family": "Xhaard", "given": "Alienor", "initials": "A"}, {"family": "Knelange", "given": "Nina", "initials": "N"}, {"family": "Styczynski", "given": "Jan", "initials": "J"}, {"family": "Mikulska", "given": "Malgorzata", "initials": "M"}, {"family": "de la Camara", "given": "Rafael", "initials": "R"}], "type": "journal article", "published": "2023-03-07", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "14", "pages": "1125824", "issn-l": "1664-3224"}, "abstract": "COVID-19 has been associated with high morbidity and mortality in allogeneic hematopoietic stem cell transplant (allo-HCT) recipients.\n\nThis study reports on 986 patients reported to the EBMT registry during the first 29 months of the pandemic.\n\nThe median age was 50.3 years (min - max; 1.0 - 80.7). The median time from most recent HCT to diagnosis of COVID-19 was 20 months (min - max; 0.0 - 383.9). The median time was 19.3 (0.0 - 287.6) months during 2020, 21.2 (0.1 - 324.5) months during 2021, and 19.7 (0.1 - 383.9) months during 2022 (p = NS). 145/986 (14.7%) patients died; 124 (12.6%) due to COVID-19 and 21 of other causes. Only 2/204 (1%) fully vaccinated patients died from COVID-19. There was a successive improvement in overall survival over time. In multivariate analysis, increasing age (p<.0001), worse performance status (p<.0001), contracting COVID-19 within the first 30 days (p<.0001) or 30 - 100 days after HCT (p=.003), ongoing immunosuppression (p=.004), pre-existing lung disease (p=.003), and recipient CMV seropositivity (p=.004) had negative impact on overall survival while patients contracting COVID-19 in 2020 (p<.0001) or 2021 (p=.027) had worse overall survival than patients with COVID-19 diagnosed in 2022.\n\nAlthough the outcome of COVID-19 has improved, patients having risk factors were still at risk for severe COVID-19 including death.", "doi": "10.3389/fimmu.2023.1125824", "pmid": "36960069", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10028143"}], "notes": [], "created": "2023-04-21T16:04:40.764Z", "modified": "2023-04-21T16:04:40.779Z"}, {"entity": "publication", "iuid": "65f05be676d24d99a94289740229f478", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65f05be676d24d99a94289740229f478.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65f05be676d24d99a94289740229f478"}}, "title": "Dissection of Antibody Responses of Gam-COVID-Vac-Vaccinated Subjects Suggests Involvement of Epitopes Outside RBD in SARS-CoV-2 Neutralization.", "authors": [{"family": "Byazrova", "given": "Maria", "initials": "M"}, {"family": "Gattinger", "given": "Pia", "initials": "P", "orcid": "0000-0001-6724-8543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d470813c45d04ab295b0df1b02d7cf93.json"}}, {"family": "Astakhova", "given": "Ekaterina", "initials": "E"}, {"family": "Hofer", "given": "Gerhard", "initials": "G"}, {"family": "Khaitov", "given": "Musa", "initials": "M"}, {"family": "Filatov", "given": "Alexander", "initials": "A", "orcid": "0000-0002-6460-9427", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68803e957803458d89d969484dc7420b.json"}}, {"family": "Valenta", "given": "Rudolf", "initials": "R"}], "type": "journal article", "published": "2023-03-07", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "24", "issue": "6", "issn-l": null}, "abstract": "Millions of people have been vaccinated with Gam-COVID-Vac but fine specificities of induced antibodies have not been fully studied. Plasma from 12 na\u00efve and 10 coronavirus disease 2019 (COVID-19) convalescent subjects was obtained before and after two immunizations with Gam-COVID-Vac. Antibody reactivity in the plasma samples (n = 44) was studied on a panel of micro-arrayed recombinant folded and unfolded severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins and 46 peptides spanning the spike protein (S) and by immunoglobulin G (IgG) subclass enzyme-linked immunosorbent assay (ELISA). The ability of Gam-COVID-Vac-induced antibodies to inhibit binding of the receptor-binding domain (RBD) to its receptor angiotensin converting enzyme 2 (ACE2) was investigated in a molecular interaction assay (MIA). The virus-neutralizing capacity of antibodies was studied by the pseudo-typed virus neutralization test (pVNT) for Wuhan-Hu-1 and Omicron. We found that Gam-COVID-Vac vaccination induced significant increases of IgG1 but not of other IgG subclasses against folded S, spike protein subunit 1 (S1), spike protein subunit 2 (S2), and RBD in a comparable manner in na\u00efve and convalescent subjects. Virus neutralization was highly correlated with vaccination-induced antibodies specific for folded RBD and a novel peptide (i.e., peptide 12). Peptide 12 was located close to RBD in the N-terminal part of S1 and may potentially be involved in the transition of the pre- to post-fusion conformation of the spike protein. In summary, Gam-COVID-Vac vaccination induced S-specific IgG1 antibodies in naive and convalescent subjects in a comparable manner. Besides the antibodies specific for RBD, the antibodies induced against a peptide close to the N-terminus of RBD were also associated with virus-neutralization.", "doi": "10.3390/ijms24065104", "pmid": "36982183", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10049224"}, {"db": "pii", "key": "ijms24065104"}], "notes": [], "created": "2023-04-21T15:56:40.490Z", "modified": "2023-04-21T15:56:40.549Z"}, {"entity": "publication", "iuid": "2b3b7fc6d3ce4e78967d2aa8eb20b4ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b3b7fc6d3ce4e78967d2aa8eb20b4ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b3b7fc6d3ce4e78967d2aa8eb20b4ae"}}, "title": "Management of patients with advanced prostate cancer-metastatic and/or castration-resistant prostate cancer: report of the Advanced Prostate Cancer Consensus Conference (APCCC) 2022.", "authors": [{"family": "Gillessen", "given": "Silke", "initials": "S"}, {"family": "Bossi", "given": "Alberto", "initials": "A"}, {"family": "Davis", "given": "Ian D", "initials": "ID"}, {"family": "de Bono", "given": "Johann", "initials": "J"}, {"family": "Fizazi", "given": "Karim", "initials": "K"}, {"family": "James", "given": "Nicholas D", "initials": "ND"}, {"family": "Mottet", "given": "Nicolas", "initials": "N"}, {"family": "Shore", "given": "Neal", "initials": "N"}, {"family": "Small", "given": "Eric", "initials": "E"}, {"family": "Smith", "given": "Matthew", "initials": "M"}, {"family": "Sweeney", "given": "Christopher J", "initials": "CJ"}, {"family": "Tombal", "given": "Bertrand", "initials": "B"}, {"family": "Antonarakis", "given": "Emmanuel S", "initials": "ES"}, {"family": "Aparicio", "given": "Ana M", "initials": "AM"}, {"family": "Armstrong", "given": "Andrew J", "initials": "AJ"}, {"family": "Attard", "given": "Gerhardt", "initials": "G"}, {"family": "Beer", "given": "Tomasz M", "initials": "TM"}, {"family": "Beltran", "given": "Himisha", "initials": "H"}, {"family": "Bjartell", "given": "Anders", "initials": "A"}, {"family": "Blanchard", "given": "Pierre", "initials": "P"}, {"family": "Briganti", "given": "Alberto", "initials": "A"}, {"family": "Bristow", "given": "Rob G", "initials": "RG"}, {"family": "Bulbul", "given": "Muhammad", "initials": "M"}, {"family": "Caffo", "given": "Orazio", "initials": "O"}, {"family": "Castellano", "given": "Daniel", "initials": "D"}, {"family": "Castro", "given": "Elena", "initials": "E"}, {"family": "Cheng", "given": "Heather H", "initials": "HH"}, {"family": "Chi", "given": "Kim N", "initials": "KN"}, {"family": "Chowdhury", "given": "Simon", "initials": "S"}, {"family": "Clarke", "given": "Caroline S", "initials": "CS"}, {"family": "Clarke", "given": "Noel", "initials": "N"}, {"family": "Daugaard", "given": "Gedske", "initials": "G"}, {"family": "De Santis", "given": "Maria", "initials": "M"}, {"family": "Duran", "given": "Ignacio", "initials": "I"}, {"family": "Eeles", "given": "Ross", "initials": "R"}, {"family": "Efstathiou", "given": "Eleni", "initials": "E"}, {"family": "Efstathiou", "given": "Jason", "initials": "J"}, {"family": "Ekeke", "given": "Onyeanunam Ngozi", "initials": "ON"}, {"family": "Evans", "given": "Christopher P", "initials": "CP"}, {"family": "Fanti", "given": "Stefano", "initials": "S"}, {"family": "Feng", "given": "Felix Y", "initials": "FY"}, {"family": "Fonteyne", "given": "Valerie", "initials": "V"}, {"family": "Fossati", "given": "Nicola", "initials": "N"}, {"family": "Frydenberg", "given": "Mark", "initials": "M"}, {"family": "George", "given": "Dan", "initials": "D"}, {"family": "Gleave", "given": "Martin", "initials": "M"}, {"family": "Gravis", "given": "Gwenaelle", "initials": "G"}, {"family": "Halabi", "given": "Susan", "initials": "S"}, {"family": "Heinrich", "given": "Daniel", "initials": "D"}, {"family": "Herrmann", "given": "Ken", "initials": "K"}, {"family": "Higano", "given": "Celestia", "initials": "C"}, {"family": "Hofman", "given": "Michael S", "initials": "MS"}, {"family": "Horvath", "given": "Lisa G", "initials": "LG"}, {"family": "Hussain", "given": "Maha", "initials": "M"}, {"family": "Jereczek-Fossa", "given": "Barbara A", "initials": "BA"}, {"family": "Jones", "given": "Rob", "initials": "R"}, {"family": "Kanesvaran", "given": "Ravindran", "initials": "R"}, {"family": "Kellokumpu-Lehtinen", "given": "Pirkko-Liisa", "initials": "PL"}, {"family": "Khauli", "given": "Raja B", "initials": "RB"}, {"family": "Klotz", "given": "Laurence", "initials": "L"}, {"family": "Kramer", "given": "Gero", "initials": "G"}, {"family": "Leibowitz", "given": "Raja", "initials": "R"}, {"family": "Logothetis", "given": "Christopher", "initials": "C"}, {"family": "Mahal", "given": "Brandon", "initials": "B"}, {"family": "Maluf", "given": "Fernando", "initials": "F"}, {"family": "Mateo", "given": "Joaquin", "initials": "J"}, {"family": "Matheson", "given": "David", "initials": "D"}, {"family": "Mehra", "given": "Niven", "initials": "N"}, {"family": "Merseburger", "given": "Axel", "initials": "A"}, {"family": "Morgans", "given": "Alicia K", "initials": "AK"}, {"family": "Morris", "given": "Michael J", "initials": "MJ"}, {"family": "Mrabti", "given": "Hind", "initials": "H"}, {"family": "Mukherji", "given": "Deborah", "initials": "D"}, {"family": "Murphy", "given": "Declan G", "initials": "DG"}, {"family": "Murthy", "given": "Vedang", "initials": "V"}, {"family": "Nguyen", "given": "Paul L", "initials": "PL"}, {"family": "Oh", "given": "William K", "initials": "WK"}, {"family": "Ost", "given": "Piet", "initials": "P"}, {"family": "O'Sullivan", "given": "Joe M", "initials": "JM"}, {"family": "Padhani", "given": "Anwar R", "initials": "AR"}, {"family": "Pezaro", "given": "Carmel J", "initials": "CJ"}, {"family": "Poon", "given": "Darren M C", "initials": "DMC"}, {"family": "Pritchard", "given": "Colin C", "initials": "CC"}, {"family": "Rabah", "given": "Danny M", "initials": "DM"}, {"family": "Rathkopf", "given": "Dana", "initials": "D"}, {"family": "Reiter", "given": "Robert E", "initials": "RE"}, {"family": "Rubin", "given": "Mark A", "initials": "MA"}, {"family": "Ryan", "given": "Charles J", "initials": "CJ"}, {"family": "Saad", "given": "Fred", "initials": "F"}, {"family": "Sade", "given": "Juan Pablo", "initials": "JP"}, {"family": "Sartor", "given": "Oliver", "initials": "O"}, {"family": "Scher", "given": "Howard I", "initials": "HI"}, {"family": "Sharifi", "given": "Nima", "initials": "N"}, {"family": "Skoneczna", "given": "Iwona", "initials": "I"}, {"family": "Soule", "given": "Howard", "initials": "H"}, {"family": "Spratt", "given": "Daniel E", "initials": "DE"}, {"family": "Srinivas", "given": "Sandy", "initials": "S"}, {"family": "Sternberg", "given": "Cora N", "initials": "CN"}, {"family": "Steuber", "given": "Thomas", "initials": "T"}, {"family": "Suzuki", "given": "Hiroyoshi", "initials": "H"}, {"family": "Sydes", "given": "Matthew R", "initials": "MR"}, {"family": "Taplin", "given": "Mary-Ellen", "initials": "ME"}, {"family": "Tilki", "given": "Derya", "initials": "D"}, {"family": "T\u00fcrkeri", "given": "Levent", "initials": "L"}, {"family": "Turco", "given": "Fabio", "initials": "F"}, {"family": "Uemura", "given": "Hiroji", "initials": "H"}, {"family": "Uemura", "given": "Hirotsugu", "initials": "H"}, {"family": "\u00dcr\u00fcn", "given": "Y\u00fcksel", "initials": "Y"}, {"family": "Vale", "given": "Claire L", "initials": "CL"}, {"family": "van Oort", "given": "Inge", "initials": "I"}, {"family": "Vapiwala", "given": "Neha", "initials": "N"}, {"family": "Walz", "given": "Jochen", "initials": "J"}, {"family": "Yamoah", "given": "Kosj", "initials": "K"}, {"family": "Ye", "given": "Dingwei", "initials": "D"}, {"family": "Yu", "given": "Evan Y", "initials": "EY"}, {"family": "Zapatero", "given": "Almudena", "initials": "A"}, {"family": "Zilli", "given": "Thomas", "initials": "T"}, {"family": "Omlin", "given": "Aurelius", "initials": "A"}], "type": "journal article", "published": "2023-03-03", "journal": {"title": "Eur J Cancer", "issn": "1879-0852", "volume": "185", "pages": "178-215", "issn-l": "0959-8049"}, "abstract": "Innovations in imaging and molecular characterisation together with novel treatment options have improved outcomes in advanced prostate cancer. However, we still lack high-level evidence in many areas relevant to making management decisions in daily clinical practise. The 2022 Advanced Prostate Cancer Consensus Conference (APCCC 2022) addressed some questions in these areas to supplement guidelines that mostly are based on level 1 evidence.\n\nTo present the voting results of the APCCC 2022.\n\nThe experts voted on controversial questions where high-level evidence is mostly lacking: locally advanced prostate cancer; biochemical recurrence after local treatment; metastatic hormone-sensitive, non-metastatic, and metastatic castration-resistant prostate cancer; oligometastatic prostate cancer; and managing side effects of hormonal therapy. A panel of 105 international prostate cancer experts voted on the consensus questions.\n\nThe panel voted on 198 pre-defined questions, which were developed by 117 voting and non-voting panel members prior to the conference following a modified Delphi process. A total of 116 questions on metastatic and/or castration-resistant prostate cancer are discussed in this manuscript. In 2022, the voting was done by a web-based survey because of COVID-19 restrictions.\n\nThe voting reflects the expert opinion of these panellists and did not incorporate a standard literature review or formal meta-analysis. The answer options for the consensus questions received varying degrees of support from panellists, as reflected in this article and the detailed voting results are reported in the supplementary material. We report here on topics in metastatic, hormone-sensitive prostate cancer (mHSPC), non-metastatic, castration-resistant prostate cancer (nmCRPC), metastatic castration-resistant prostate cancer (mCRPC), and oligometastatic and oligoprogressive prostate cancer.\n\nThese voting results in four specific areas from a panel of experts in advanced prostate cancer can help clinicians and patients navigate controversial areas of management for which high-level evidence is scant or conflicting and can help research funders and policy makers identify information gaps and consider what areas to explore further. However, diagnostic and treatment decisions always have to be individualised based on patient characteristics, including the extent and location of disease, prior treatment(s), co-morbidities, patient preferences, and treatment recommendations and should also incorporate current and emerging clinical evidence and logistic and economic factors. Enrolment in clinical trials is strongly encouraged. Importantly, APCCC 2022 once again identified important gaps where there is non-consensus and that merit evaluation in specifically designed trials.\n\nThe Advanced Prostate Cancer Consensus Conference (APCCC) provides a forum to discuss and debate current diagnostic and treatment options for patients with advanced prostate cancer. The conference aims to share the knowledge of international experts in prostate cancer with healthcare providers worldwide. At each APCCC, an expert panel votes on pre-defined questions that target the most clinically relevant areas of advanced prostate cancer treatment for which there are gaps in knowledge. The results of the voting provide a practical guide to help clinicians discuss therapeutic options with patients and their relatives as part of shared and multidisciplinary decision-making. This report focuses on the advanced setting, covering metastatic hormone-sensitive prostate cancer and both non-metastatic and metastatic castration-resistant prostate cancer.\n\nReport of the results of APCCC 2022 for the following topics: mHSPC, nmCRPC, mCRPC, and oligometastatic prostate cancer.\n\nAt APCCC 2022, clinically important questions in the management of advanced prostate cancer management were identified and discussed, and experts voted on pre-defined consensus questions. The report of the results for metastatic and/or castration-resistant prostate cancer is summarised here.", "doi": "10.1016/j.ejca.2023.02.018", "pmid": "37003085", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0959-8049(23)00110-7"}], "notes": [], "created": "2023-04-20T17:40:52.720Z", "modified": "2023-04-20T17:40:52.732Z"}, {"entity": "publication", "iuid": "7af7ee094d4a43fdb14612045b40587b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7af7ee094d4a43fdb14612045b40587b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7af7ee094d4a43fdb14612045b40587b"}}, "title": "Optimising conditions and environments for digital participation in later life: A macro-meso-micro framework of partnership-building.", "authors": [{"family": "Reuter", "given": "Arlind", "initials": "A"}, {"family": "Xu", "given": "Wenqian", "initials": "W"}, {"family": "Iwarsson", "given": "Susanne", "initials": "S"}, {"family": "Olsson", "given": "Tobias", "initials": "T"}, {"family": "Schmidt", "given": "Steven M", "initials": "SM"}], "type": "journal article", "published": "2023-03-02", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "14", "pages": "1107024", "issn-l": "1664-1078"}, "abstract": "The ongoing digitalisation of societies, exacerbated by the COVID-19 pandemic, has led to increased efforts to ensure the digital inclusion of older adults. Digital inclusion strategies throughout the COVID-19 pandemic predominantly focused on increasing access and basic digital literacy of Information and Communication Technologies (ICTs) for all members of society. Older adults, who are more likely to experience digital exclusion, are amongst the target groups of digital inclusion strategies. We propose that beyond digital inclusion, there is a need to focus on digital participation and optimise opportunities for everyone to participate in communities and society in post-pandemic times. Creative digital skills are the foundation of digital participation and can lead to a variety of contributions. Digital participation offers conditions that support agency and active contributions in a digitalised society. Taking macro-, meso-, and micro-level enablers of digital participation in later life into account, we argue for the establishment and implementation of multi-layered and multisectoral partnerships that address environmental factors (including social and physical dimensions) of digital participation and create opportunities for diverse, meaningful and fulfilling engagement with ICTs in later life. The partnership approach can be used in designing and implementing digital participation programmes and should be further evaluated against the needs and lived experiences of older individuals. Foresighted research is needed to investigate key factors of effective partnerships for optimising environments for digital participation in later life.", "doi": "10.3389/fpsyg.2023.1107024", "pmid": "36936014", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10017487"}], "notes": [], "created": "2023-04-21T16:10:59.315Z", "modified": "2023-04-21T16:10:59.331Z"}, {"entity": "publication", "iuid": "bec28b7a63e44bd58fc76b207fe907d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bec28b7a63e44bd58fc76b207fe907d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bec28b7a63e44bd58fc76b207fe907d5"}}, "title": "Prevalence and Characteristics Associated With Post-COVID-19 Condition Among Nonhospitalized Adolescents and Young Adults.", "authors": [{"family": "Selvakumar", "given": "Joel", "initials": "J"}, {"family": "Havdal", "given": "Lise Beier", "initials": "LB"}, {"family": "Drevvatne", "given": "Martin", "initials": "M"}, {"family": "Brodwall", "given": "Elias Myrstad", "initials": "EM"}, {"family": "Lund Berven", "given": "Lise", "initials": "L"}, {"family": "Stiansen-Sonerud", "given": "Tonje", "initials": "T"}, {"family": "Einvik", "given": "Gunnar", "initials": "G"}, {"family": "Leegaard", "given": "Truls Michael", "initials": "TM"}, {"family": "Tjade", "given": "Trygve", "initials": "T"}, {"family": "Michelsen", "given": "Annika E", "initials": "AE"}, {"family": "Mollnes", "given": "Tom Eirik", "initials": "TE"}, {"family": "Lund-Johansen", "given": "Fridtjof", "initials": "F"}, {"family": "Holm\u00f8y", "given": "Trygve", "initials": "T"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Sandler", "given": "Carolina X", "initials": "CX"}, {"family": "Cvejic", "given": "Erin", "initials": "E"}, {"family": "Lloyd", "given": "Andrew R", "initials": "AR"}, {"family": "Wyller", "given": "Vegard Bruun Bratholm", "initials": "VBB"}], "type": "journal article", "published": "2023-03-01", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "volume": "6", "issue": "3", "pages": "e235763", "issn-l": null}, "abstract": "The prevalence and baseline risk factors of post-COVID-19 condition (PCC) remain unresolved among the large number of young people who experienced mild COVID-19.\n\nTo determine the point prevalence of PCC 6 months after the acute infection, to determine the risk of development of PCC adjusted for possible confounders, and to explore a broad range of potential risk factors.\n\nThis cohort study included nonhospitalized individuals from 2 counties in Norway between ages 12 and 25 years who underwent reverse transcription-polymerase chain reaction (RT-PCR) testing. At the early convalescent stage and at 6-month follow-up, participants underwent a clinical examination; pulmonary, cardiac, and cognitive functional testing; immunological and organ injury biomarker analyses; and completion of a questionnaire. Participants were classified according to the World Health Organization case definition of PCC at follow-up. Association analyses of 78 potential risk factors were performed.\n\nSARS-CoV-2 infection.\n\nThe point prevalence of PCC 6 months after RT-PCR testing in the SARS-CoV-2-positive and SARS-CoV-2-negative groups, and the risk difference with corresponding 95% CIs.\n\nA total of 404 individuals testing positive for SARS-CoV-2 and 105 individuals testing negative were enrolled (194 male [38.1%]; 102 non-European [20.0%] ethnicity). A total of 22 of the SARS-CoV-2-positive and 4 of the SARS-CoV-2-negative individuals were lost to follow-up, and 16 SARS-CoV-2-negative individuals were excluded due to SARS-CoV-2 infection in the observational period. Hence, 382 SARS-CoV-2-positive participants (mean [SD] age, 18.0 [3.7] years; 152 male [39.8%]) and 85 SARS-CoV-2-negative participants (mean [SD] age, 17.7 [3.2] years; 31 male [36.5%]) could be evaluated. The point prevalence of PCC at 6 months was 48.5% in the SARS-CoV-2-positive group and 47.1% in the control group (risk difference, 1.5%; 95% CI, -10.2% to 13.1%). SARS-CoV-2 positivity was not associated with the development of PCC (relative risk [RR], 1.06; 95% CI, 0.83 to 1.37; final multivariable model utilizing modified Poisson regression). The main risk factor for PCC was symptom severity at baseline (RR, 1.41; 95% CI, 1.27-1.56). Low physical activity (RR, 0.96; 95% CI, 0.92-1.00) and loneliness (RR, 1.01; 95% CI, 1.00-1.02) were also associated, while biological markers were not. Symptom severity correlated with personality traits.\n\nThe persistent symptoms and disability that characterize PCC are associated with factors other than SARS-CoV-2 infection, including psychosocial factors. This finding raises questions about the utility of the World Health Organization case definition and has implications for the planning of health care services as well as for further research on PCC.", "doi": "10.1001/jamanetworkopen.2023.5763", "pmid": "36995712", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC10064252"}, {"db": "pii", "key": "2802893"}], "notes": [], "created": "2023-04-21T15:52:21.113Z", "modified": "2023-04-21T15:53:16.684Z"}, {"entity": "publication", "iuid": "81e376782a4948a7aa3e7bdc7c9c1609", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/81e376782a4948a7aa3e7bdc7c9c1609.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/81e376782a4948a7aa3e7bdc7c9c1609"}}, "title": "Frequent use of IGHV3-30-3 in SARS-CoV-2 neutralizing antibody responses.", "authors": [{"family": "Pushparaj", "given": "Pradeepa", "initials": "P"}, {"family": "Nicoletto", "given": "Andrea", "initials": "A"}, {"family": "Dopico", "given": "Xaquin Castro", "initials": "XC"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Kim", "given": "Sungyong", "initials": "S"}, {"family": "Ekstr\u00f6m", "given": "Simon", "initials": "S"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Corcoran", "given": "Martin", "initials": "M"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}], "type": "journal article", "published": "2023-03-01", "journal": {"title": "Front Virol", "issn": "2673-818X", "issn-l": null, "volume": "3", "issue": null, "pages": "1128253"}, "abstract": "The antibody response to SARS-CoV-2 shows biased immunoglobulin heavy chain variable (IGHV) gene usage, allowing definition of genetic signatures for some classes of neutralizing antibodies. We investigated IGHV gene usage frequencies by sorting spike-specific single memory B cells from individuals infected with SARS-CoV-2 early in the pandemic. From two study participants and 703 spikespecific B cells, the most used genes were IGHV1-69, IGHV3-30-3, and IGHV3-30. Here, we focused on the IGHV3-30 group of genes and an IGHV3-30-3-using ultrapotent neutralizing monoclonal antibody, CAB-F52, which displayed broad neutralizing activity also in its germline-reverted form. IGHV3-30-3 is encoded by a region of the IGH locus that is highly variable at both the allelic and structural levels. Using personalized IG genotyping, we found that 4 of 14 study participants lacked the IGHV3-30-3 gene on both chromosomes, raising the question if other, highly similar IGHV genes could substitute for IGHV3-30-3 in persons lacking this gene. In the context of CAB-F52, we found that none of the tested IGHV3-33 alleles, but several IGHV3-30 alleles could substitute for IGHV3-30-3, suggesting functional redundancy between the highly homologous IGHV3-30 and IGHV3-30-3 genes for this antibody.", "doi": "10.3389/fviro.2023.1128253", "pmid": "37041983", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC7614418"}, {"db": "URL", "key": "https://www.frontiersin.org/articles/10.3389/fviro.2023.1128253/full#supplementary-material", "description": "https://www.frontiersin.org/articles/10.3389/fviro.2023.1128253/full#supplementary-material"}], "notes": [], "created": "2023-04-12T17:02:23.880Z", "modified": "2023-04-12T17:03:49.485Z"}, {"entity": "publication", "iuid": "66de20f884d741cf9c6fe15b97766203", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66de20f884d741cf9c6fe15b97766203.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66de20f884d741cf9c6fe15b97766203"}}, "title": "Tissue factor activity of small and large extracellular vesicles in different diseases.", "authors": [{"family": "Sachetto", "given": "Ana T A", "initials": "ATA"}, {"family": "Archibald", "given": "Sierra J", "initials": "SJ"}, {"family": "Hisada", "given": "Yohei", "initials": "Y"}, {"family": "Rosell", "given": "Axel", "initials": "A"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "van Es", "given": "Nick", "initials": "N"}, {"family": "Nieuwland", "given": "Rienk", "initials": "R"}, {"family": "Campbell", "given": "Robert A", "initials": "RA"}, {"family": "Middleton", "given": "Elizabeth A", "initials": "EA"}, {"family": "Rondina", "given": "Matthew T", "initials": "MT"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "Res Pract Thromb Haemost", "issn": "2475-0379", "volume": "7", "issue": "3", "pages": "100124", "issn-l": null}, "abstract": "Circulating procoagulant extracellular vesicles (EVs) are increased in diseases, such as cancer, sepsis, and COVID-19. EV tissue factor (TF) activity is associated with disseminated intravascular coagulation in sepsis and venous thrombosis in patients with pancreatic cancer and COVID-19. EVs are commonly isolated by centrifugation at \u223c20,000 g.\n\nIn this study, we analyzed the TF activity of 2 EV populations enriched for large and small EVs in patients with either sepsis, pancreatic cancer, or COVID-19.\n\nEVs were isolated from plasma by sequential centrifugation at 20,000 g (large EVs, LEVs) and then 100,000 g (small EVs, SEVs). We analyzed EVs from plasma prepared from whole blood samples from healthy individuals with or without lipopolysaccharide (LPS) stimulation as well as EVs from plasma samples from patients with either sepsis, pancreatic cancer, or COVID-19. TF-dependent (EV-TF activity) and TF-independent factor Xa (FXa) generation of the EVs was measured.\n\nLPS increased EV-TF activity in LEVs but not SEVs. Similarly, in 2 patients with sepsis who had EV-TF activity above the background of the assay we observed EV-TF activity in LEVs but not SEVs. Patients with pancreatic cancer or COVID-19 had circulating EV-TF activity in both LEVs and SEVs.\n\nWe recommend that EVs are isolated from plasma from patients by centrifugation at 100,000 g rather than 20,000 g to obtain a more accurate measure of levels of circulating EV-TF activity.", "doi": "10.1016/j.rpth.2023.100124", "pmid": "37012986", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10015082"}, {"db": "pii", "key": "S2475-0379(23)00095-X"}], "notes": [], "created": "2023-04-12T16:53:04.397Z", "modified": "2023-04-20T17:35:04.601Z"}, {"entity": "publication", "iuid": "5c1c1d407c184180b0f336a10852eb68", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c1c1d407c184180b0f336a10852eb68.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c1c1d407c184180b0f336a10852eb68"}}, "title": "The effect of time spent sitting and excessive gaming on the weight status, and perceived weight stigma among Taiwanese young adults.", "authors": [{"family": "Kamolthip", "given": "Ruckwongpatr", "initials": "R"}, {"family": "Yang", "given": "Yung-Ning", "initials": "YN"}, {"family": "Latner", "given": "Janet D", "initials": "JD"}, {"family": "O'Brien", "given": "Kerry S", "initials": "KS"}, {"family": "Chang", "given": "Yen-Ling", "initials": "YL"}, {"family": "Lin", "given": "Chien-Chin", "initials": "CC"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": "9", "issue": "3", "pages": "e14298", "issn-l": null}, "abstract": "During the COVID-19 pandemic, physical inactivity and sedentary behaviors (i.e., longer sitting time and excessive gaming) increased because governments across the globe adopted stringent mitigation strategies such as social distancing and lockdowns to curb the spread of the virus. Excessive gaming was one of the coping mechanisms used to deal with the pressure associated with the pandemic. Moreover, perceived weight stigma (PWS) and weight status became more salient concerns among young adults during the COVID-19 pandemic. The current study sought to investigate the relationship between time spent sitting, excessive gaming, weight status, and PWS of Taiwanese Young adults. Additionally, weight status and PWS were examined as mediators between both sedentary behaviors.\n\nThis cross-sectional study involved 600 participants who were recruited through Taiwan universities. All participants completed a demographic questionnaire (including weight and height) and self-report measures including the International Physical Activity Questionnaire short form (IPAQ-SF), the Perceived Weight Stigma Scale (PWSS), and the Internet Gaming Disorder Scale-short form (IGDS9-SF). PROCESS model was performed to test the potential mediation roles of weight status and PWS. Moreover, we categorized participants into two groups based on the sitting-time item in the IPAQ-SF: students whose sitting time was less than 8 h daily, and those more than 8 h daily.\n\nThe group that had less than 8 h had significantly higher PWS and IGDS9-SF scores than the other group. Sitting time was negatively associated with weight status, PWS, and IGDS9-SF. Additionally, we found a significantly direct effect between time spent sitting and excessive gaming. Both weight status and PWS were significant mediators in the association between time spent sitting and excessive gaming.Conclusions: The present study demonstrated important negative correlates of excessive sedentary behaviors. Prevention efforts should focus on promoting physical activity and providing information to decrease sedentary behavior among university students.", "doi": "10.1016/j.heliyon.2023.e14298", "pmid": "36938463", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10018563"}, {"db": "pii", "key": "S2405-8440(23)01505-0"}], "notes": [], "created": "2023-04-21T16:09:37.800Z", "modified": "2023-04-21T16:09:37.814Z"}, {"entity": "publication", "iuid": "befbcb1b88f84f8ab93f91ad0015f19e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/befbcb1b88f84f8ab93f91ad0015f19e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/befbcb1b88f84f8ab93f91ad0015f19e"}}, "title": "Prevalence of ongoing or previous SARS-CoV-2 infection among dental personnel - the Swedish experience.", "authors": [{"family": "Fredriksson", "given": "Lars", "initials": "L"}, {"family": "Cederlund", "given": "Andreas", "initials": "A"}, {"family": "Murray", "given": "My", "initials": "M"}, {"family": "Jansson", "given": "Leif", "initials": "L"}, {"family": "Skott", "given": "Pia", "initials": "P"}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "Acta Odontol Scand", "issn": "1502-3850", "pages": "119-123", "volume": "81", "issue": "2", "issn-l": null}, "abstract": "The seroprevalence of SARS-CoV-2 infection was approximately similar to that in healthcare personnel, and approximately equal compared to that in the general population.\n\nWe carried out an observational cohort study from March to June 2020, including 341 employees randomly selected from Public Dental Service in the County of Stockholm. The primary outcome variable was the prevalence of SARS-CoV-2 RNA and/or antibodies against SARS-CoV-2. Throat samples were analysed for SARS-CoV-2 RNA. Venous blood was collected to detect antibodies against SARS-CoV-2 using the Luminex analysis tool (immunoassay) and ELISA. Logistic regression analysis was used to compare the independent groups and calculate the unadjusted odds ratio.\n\nTo investigate whether personnel in a public dental clinic had a higher frequency of ongoing or previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection than hospital healthcare workers or the general public in Stockholm during weeks 23-25 in 2020.\n\nThe mean age of the participants was 50.1 years, and 11.7% were male. The prevalence of SARS-CoV-2 RNA and/or antibodies against SARS-CoV-2 was 12.0% (95% confidence interval 8.8-16.0). Among them, 82.5% reported symptoms and 85.4% were on sick-leave between March and June 2020.", "doi": "10.1080/00016357.2022.2095023", "pmid": "35771959", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-19T05:28:40.708Z", "modified": "2023-02-27T17:23:18.839Z"}, {"entity": "publication", "iuid": "a6335c7e323041f087c9920a70e0af66", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6335c7e323041f087c9920a70e0af66.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6335c7e323041f087c9920a70e0af66"}}, "title": "Postmortem lung and heart examination of COVID-19 patients in a case series from Jordan.", "authors": [{"family": "Abdaljaleel", "given": "Maram", "initials": "M"}, {"family": "Tawalbeh", "given": "Isra", "initials": "I"}, {"family": "Sallam", "given": "Malik", "initials": "M"}, {"family": "Hani", "given": "Amjad Bani", "initials": "AB"}, {"family": "Al-Abdallat", "given": "Imad M", "initials": "IM"}, {"family": "Omari", "given": "Baheth Al", "initials": "BA"}, {"family": "Al-Mustafa", "given": "Sahar", "initials": "S"}, {"family": "Abder-Rahman", "given": "Hasan", "initials": "H"}, {"family": "Abbas", "given": "Adnan Said", "initials": "AS"}, {"family": "Zureigat", "given": "Mahmoud", "initials": "M"}, {"family": "Al-Abbadi", "given": "Mousa A", "initials": "MA"}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "J Pathol Transl Med", "issn": "2383-7837", "volume": "57", "issue": "2", "pages": "102-112", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) has emerged as a pandemic for more than 2 years. Autopsy examination is an invaluable tool to understand the pathogenesis of emerging infections and their consequent mortalities. The aim of the current study was to present the lung and heart pathological findings of COVID-19-positive autopsies performed in Jordan.\n\nThe study involved medicolegal cases, where the cause of death was unclear and autopsy examination was mandated by law. We included the clinical and pathologic findings of routine gross and microscopic examination of cases that were positive for COVID-19 at time of death. Testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was confirmed through molecular detection by real-time polymerase chain reaction, serologic testing for IgM and electron microscope examination of lung samples.\n\nSeventeen autopsies were included, with male predominance (76.5%), Jordanians (70.6%), and 50 years as the mean age at time of death. Nine out of 16 cases (56.3%) had co-morbidities, with one case lacking such data. Histologic examination of lung tissue revealed diffuse alveolar damage in 13/17 cases (76.5%), and pulmonary microthrombi in 8/17 cases (47.1%). Microscopic cardiac findings were scarcely detected. Two patients died as a direct result of acute cardiac disease with limited pulmonary findings.\n\nThe detection of SARS-CoV-2 in postmortem examination can be an incidental or contributory finding which highlights the value of autopsy examination to determine the exact cause of death in controversial cases.", "doi": "10.4132/jptm.2023.01.30", "pmid": "36950812", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10028009"}, {"db": "pii", "key": "jptm.2023.01.30"}], "notes": [], "created": "2023-04-21T16:06:18.219Z", "modified": "2023-04-21T16:06:18.249Z"}, {"entity": "publication", "iuid": "b7acd11c71a747c680184bf65a33eab4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b7acd11c71a747c680184bf65a33eab4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b7acd11c71a747c680184bf65a33eab4"}}, "title": "Ending tuberculosis in Europe - resetting the course in the post-COVID-19 era.", "authors": [{"family": "Ammon", "given": "Andrea", "initials": "A"}, {"family": "Kluge", "given": "Hans", "initials": "H"}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "28", "issue": "12", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2023.28.12.2300164", "pmid": "36951785", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10037663"}], "notes": [], "created": "2023-04-21T16:05:58.119Z", "modified": "2023-04-21T16:05:58.133Z"}, {"entity": "publication", "iuid": "bc340dba244547368876643044926ea9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bc340dba244547368876643044926ea9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bc340dba244547368876643044926ea9"}}, "title": "Clinical Psychology and the COVID-19 Pandemic: A Mixed Methods Survey Among Members of the European Association of Clinical Psychology and Psychological Treatment (EACLIPT).", "authors": [{"family": "Asbrand", "given": "Julia", "initials": "J", "orcid": "0000-0003-2740-6070", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ec60c3248048dc9d2d6f6295532c82.json"}}, {"family": "Gerdes", "given": "Samantha", "initials": "S", "orcid": "0009-0005-5352-2878", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5baa03eb311c425abe9e7a6242f22a1b.json"}}, {"family": "Breedvelt", "given": "Josefien", "initials": "J", "orcid": "0000-0003-1864-1861", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ef1cfcb7b74c2ab3cb66fb32c3ef94.json"}}, {"family": "Guidi", "given": "Jenny", "initials": "J", "orcid": "0000-0001-6815-2738", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/723aedb65169433cb51b99314509c977.json"}}, {"family": "Hirsch", "given": "Colette", "initials": "C", "orcid": "0000-0003-3579-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/23f55b6faf8d4c8884beeb5bfabb26b2.json"}}, {"family": "Maercker", "given": "Andreas", "initials": "A", "orcid": "0000-0001-6925-3266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15a03c24689741fb919740b0e4dda05c.json"}}, {"family": "Douilliez", "given": "C\u00e9line", "initials": "C", "orcid": "0000-0001-8912-885X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d387fee028b944c9829f6053498b629e.json"}}, {"family": "Andersson", "given": "Gerhard", "initials": "G", "orcid": "0000-0003-4753-6745", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b4074e5f32e453598de03ffcd897f67.json"}}, {"family": "Debban\u00e9", "given": "Martin", "initials": "M", "orcid": "0000-0002-4677-8753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/974ab9e42dd84d5f8bc7968dadd26022.json"}}, {"family": "Cieslak", "given": "Roman", "initials": "R", "orcid": "0000-0002-2413-5343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc9c0ccb0bbb4952b0ef1902d6a92a37.json"}}, {"family": "Rief", "given": "Winfried", "initials": "W", "orcid": "0000-0002-7019-2250", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9e36a5b17d640ec8f3f3f4c185a521e.json"}}, {"family": "Bockting", "given": "Claudi", "initials": "C", "orcid": "0000-0002-9220-9244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/281735678af94747b23f8f95cf1696bf.json"}}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "Clin Psychol Eur", "issn": "2625-3410", "volume": "5", "issue": "1", "pages": "e8109", "issn-l": null}, "abstract": "The COVID-19 pandemic has affected people globally both physically and psychologically. The increased demands for mental health interventions provided by clinical psychologists, psychotherapists and mental health care professionals, as well as the rapid change in work setting (e.g., from face-to-face to video therapy) has proven challenging. The current study investigates European clinical psychologists and psychotherapists' views on the changes and impact on mental health care that occurred due to the COVID-19 pandemic. It further aims to explore individual and organizational processes that assist clinical psychologists' and psychotherapists' in their new working conditions, and understand their needs and priorities.\n\nMembers of the European Association of Clinical Psychology and Psychological Treatment (EACLIPT) were invited (N = 698) to participate in a survey with closed and open questions covering their experiences during the first wave of the pandemic from June to September 2020. Participants (n = 92) from 19 European countries, mostly employed in universities or hospitals, completed the online survey.\n\nResults of qualitative and quantitative analyses showed that clinical psychologists and psychotherapists throughout the first wave of the COVID-19 pandemic managed to continue to provide treatments for patients who were experiencing emotional distress. The challenges (e.g., maintaining a working relationship through video treatment) and opportunities (e.g., more flexible working hours) of working through this time were identified.\n\nRecommendations for mental health policies and professional organizations are identified, such as clear guidelines regarding data security and workshops on conducting video therapy.", "doi": "10.32872/cpe.8109", "pmid": "37064999", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10103154"}, {"db": "pii", "key": "cpe.8109"}], "notes": [], "created": "2023-04-20T17:22:54.225Z", "modified": "2023-04-20T17:22:54.619Z"}, {"entity": "publication", "iuid": "92d1c3da53bc4fffb69d6dfba60ffa5d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/92d1c3da53bc4fffb69d6dfba60ffa5d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/92d1c3da53bc4fffb69d6dfba60ffa5d"}}, "title": "At-home sampling to meet geographical challenges for serological assessment of SARS-CoV-2 exposure in a rural region of northern Sweden, March to May 2021: a retrospective cohort study.", "authors": [{"family": "Bystr\u00f6m", "given": "Julia Wigren", "initials": "JW"}, {"family": "Vikstr\u00f6m", "given": "Linnea", "initials": "L"}, {"family": "Rosendal", "given": "Ebba", "initials": "E"}, {"family": "Gr\u00f6ning", "given": "Remigius", "initials": "R"}, {"family": "Gwon", "given": "Yong-Dae", "initials": "Y"}, {"family": "Nilsson", "given": "Emma", "initials": "E"}, {"family": "Sharma", "given": "Atin", "initials": "A"}, {"family": "Espaillat", "given": "Akbar", "initials": "A"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Puhar", "given": "Andrea", "initials": "A"}, {"family": "Cava", "given": "Felipe", "initials": "F"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Thunberg", "given": "Therese", "initials": "T"}, {"family": "Monsen", "given": "Tor", "initials": "T"}, {"family": "Elgh", "given": "Fredrik", "initials": "F"}, {"family": "Evander", "given": "Magnus", "initials": "M"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Forsell", "given": "Mattias Ne", "initials": "MN"}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "13", "pages": null}, "abstract": "BackgroundThe current SARS-CoV-2 pandemic has highlighted a need for easy and safe blood sampling in combination with accurate serological methodology. Venipuncture for testing is usually performed by trained staff at healthcare centres. Long travel distances to healthcare centres in rural regions may introduce a bias of testing towards relatively large communities with closer access. Rural regions are therefore often not represented in population-based data.AimThe aim of this retrospective cohort study was to develop and implement a strategy for at-home testing in a rural region of Sweden during spring 2021, and to evaluate its role to provide equal health care for its inhabitants.MethodsWe developed a sensitive method to measure antibodies to the S-protein of SARS-CoV-2 and optimised this assay for clinical use together with a strategy of at-home capillary blood sampling.ResultsWe demonstrated that our ELISA gave comparable results after analysis of capillary blood or serum from SARS-CoV-2-experienced individuals. We demonstrated stability of the assay under conditions that reflected temperature and humidity during winter or summer. By assessment of capillary blood samples from 4,122 individuals, we could show both feasibility of the strategy and that implementation shifted the geographical spread of testing in favour of rural areas.ConclusionImplementation of at-home sampling enabled citizens living in remote rural areas access to centralised and sensitive laboratory antibody tests. The strategy for testing used here could therefore enable disease control authorities to get rapid access to information concerning immunity to infectious diseases, even across vast geographical distance.", "doi": "10.2807/1560-7917.ES.2023.28.13.2200432", "pmid": "36995373", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null, "Funder: VR": null, "Funder: Vinnova": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC10064644"}], "notes": [], "created": "2023-04-12T16:46:21.928Z", "modified": "2023-04-12T16:57:03.602Z"}, {"entity": "publication", "iuid": "c156297880874d289605794386f2ba0f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c156297880874d289605794386f2ba0f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c156297880874d289605794386f2ba0f"}}, "title": "Arrival flight efficiency in pre- and post-Covid-19 pandemics.", "authors": [{"family": "Lemetti", "given": "Anastasia", "initials": "A"}, {"family": "Hardell", "given": "Henrik", "initials": "H"}, {"family": "Polishchuk", "given": "Tatiana", "initials": "T"}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "J Air Transp Manag", "issn": "1873-2089", "volume": "107", "pages": "102327", "issn-l": null}, "abstract": "Covid-19 pandemic affected aviation severely, resulting in unprecedented reduction of air traffic. While aviation is slowly re-gaining traffic volumes, we use the opportunity to study the arrival performance in the Terminal Maneuvering Area (TMA) in non-congested scenarios. Applying flight efficiency and environmental performance indicators (PIs) to the historical data of arrivals to Stockholm Arlanda and Gothenburg Landvetter airports, we discover noticeable inefficiencies, despite significant reduction of traffic intensity. We analyze the impact of such factors as weather and traffic intensity on arrival efficiency in isolated scenarios when only one factor dominates: isolated scenario with low traffic and isolated scenario with good weather conditions. Our analysis uncovers that weather has a stronger influence than traffic intensity on the vertical efficiency, while traffic intensity has stronger effect on the lateral efficiency. Impact of traffic intensity on the lateral efficiency might be explained by frequent hold-on patterns and flight trajectory extensions due to vectoring in high traffic conditions. Further investigation is needed to explain weather and vertical/lateral efficiency correlations, the conclusions might be country-specific.", "doi": "10.1016/j.jairtraman.2022.102327", "pmid": "36408128", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0969-6997(22)00146-6"}, {"db": "pmc", "key": "PMC9647021"}], "notes": [], "created": "2022-11-22T10:03:00.151Z", "modified": "2022-11-22T10:03:11.662Z"}, {"entity": "publication", "iuid": "c0d8bacc5149404fb602a317c0f3e022", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c0d8bacc5149404fb602a317c0f3e022.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c0d8bacc5149404fb602a317c0f3e022"}}, "title": "Structures for collaboration and networked adaptation: Emerging themes from the COVID-19 pandemic", "authors": [{"family": "Antonsen", "given": "PhD, Stian", "initials": "PS"}, {"family": "Haavik", "given": "PhD, Torgeir Kolst\u00f8", "initials": "PTK"}, {"family": "Frykmer", "given": "PhD, Tove", "initials": "PT"}, {"family": "Gj\u00f8sund", "given": "Gudveig", "initials": "G"}], "type": "journal-article", "published": "2023-02-28", "journal": {"title": "J Emerg Manag", "issn": "1543-5865", "issn-l": null, "volume": "21", "issue": "7", "pages": "71-84"}, "abstract": null, "doi": "10.5055/jem.0705", "pmid": null, "labels": {"Category: Social Science & Humanities": null, "Type: Other": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:12:23.449Z", "modified": "2023-10-04T08:17:14.166Z"}, {"entity": "publication", "iuid": "1bf2e234720541e487e3d31dd629578b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1bf2e234720541e487e3d31dd629578b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1bf2e234720541e487e3d31dd629578b"}}, "title": "Editorial: Health service management and leadership: COVID-style.", "authors": [{"family": "Dadich", "given": "Ann", "initials": "A"}, {"family": "Buttigieg", "given": "Sandra", "initials": "S"}, {"family": "Macassa", "given": "Gloria", "initials": "G"}, {"family": "West", "given": "Thomas", "initials": "T"}], "type": "editorial", "published": "2023-02-28", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "11", "pages": "1141055", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2023.1141055", "pmid": "36926174", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10011686"}], "notes": [], "created": "2023-04-21T16:13:05.921Z", "modified": "2023-04-21T16:13:05.938Z"}, {"entity": "publication", "iuid": "3af35c66db2c41009aed93edbb5d0054", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3af35c66db2c41009aed93edbb5d0054.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3af35c66db2c41009aed93edbb5d0054"}}, "title": "Worldwide Estimation of Parental Acceptance of COVID-19 Vaccine for Their Children: A Systematic Review and Meta-Analysis.", "authors": [{"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2023-02-24", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "11", "issue": "3", "issn-l": null}, "abstract": "Currently, the best method to well control the spread of COVID-19 without severe mental health problems is to reach herd immunity. Therefore, the vaccination rate of the COVID-19 vaccine is critical. Among the populations, children are the vulnerable ones to get vaccinated; therefore, it is important to assess parents' and guardians' willingness to have their children vaccinated. The present systematic review and meta-analysis synthesized evidence to estimate the parents' acceptance rate of COVID-19 vaccination toward their children. Additionally, factors explaining the acceptance rate were investigated. Four academic databases (PubMed, Scopus, Web of Science, and ProQuest) together with Google Scholar were searched, and the references of the included publications were searched as well. Using the PECO-S framework (population, exposure, comparison, outcome, and study design), observational studies of cross-sectional, cohort, or case-control studies were included. The outcome was parents' or guardians' willingness to let their children be vaccinated. The studies included in the present review were restricted to English and peer-reviewed papers published between December 2019 and July 2022. A total of 98 papers across 69 different countries with 413,590 participants were included. The mean age of the parents was 39.10 (range: 18-70) years and that of their children was 8.45 (range: 0-18) years. The pooled estimated prevalence of parental acceptance to vaccinate their children with the COVID-19 vaccine was 57% (98 studies, 95% CI: 52-62%, I2: 99.92%, \u03c42: 0.06). Moreover, data collection time was a significant factor explaining parental willingness in the multivariable meta-regression, with a 13% decrease in parental willingness by each month increase in time, explaining 11.44% of variance. Qualitative synthesis results showed that parents' COVID-19 vaccine knowledge, trust in theCOVID-19 vaccine, and facilitators in vaccination (e.g., low cost, good vaccine accessibility, and government incentive) were significant factors for higher willingness, while mental health problems (e.g., having worries and psychological distress) were significant factors for lower willingness. Given that the acceptance rate was relatively low (57%) and does not achieve the requirement of herd immunity (i.e., 70%), governments and healthcare authorities should try to elevate parents' knowledge and trust in the COVID-19 vaccine, facilitate in vaccination, and reduce their mental difficulties to improve the overall vaccination rate among children.", "doi": "10.3390/vaccines11030533", "pmid": "36992117", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10051081"}, {"db": "pii", "key": "vaccines11030533"}], "notes": [], "created": "2023-04-21T15:55:33.559Z", "modified": "2023-04-21T15:55:33.576Z"}, {"entity": "publication", "iuid": "f1eb1c6f4d1f4c57b823461a287975eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1eb1c6f4d1f4c57b823461a287975eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1eb1c6f4d1f4c57b823461a287975eb"}}, "title": "Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia.", "authors": [{"family": "Palma Medina", "given": "Laura M", "initials": "LM"}, {"family": "Baba\u010di\u0107", "given": "Haris", "initials": "H"}, {"family": "Dzidic", "given": "Majda", "initials": "M"}, {"family": "Parke", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Garcia", "given": "Marina", "initials": "M"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Unge", "given": "Christian", "initials": "C"}, {"family": "Lourda", "given": "Magda", "initials": "M"}, {"family": "Kvedaraite", "given": "Egle", "initials": "E"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Muvva", "given": "Jagadeeswara Rao", "initials": "JR"}, {"family": "Cornillet", "given": "Martin", "initials": "M"}, {"family": "Emg\u00e5rd", "given": "Johanna", "initials": "J"}, {"family": "Moll", "given": "Kirsten", "initials": "K"}, {"family": "Karolinska K. I./K. COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Flodstr\u00f6m-Tullberg", "given": "Malin", "initials": "M"}, {"family": "Brighenti", "given": "Susanna", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J"}, {"family": "Malmberg", "given": "Karl-Johan", "initials": "KJ"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Svensson", "given": "Mattias", "initials": "M"}, {"family": "Chambers", "given": "Benedict J", "initials": "BJ"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Pernemalm", "given": "Maria", "initials": "M"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2023-02-24", "journal": {"title": "Respir Res", "issn": "1465-993X", "volume": "24", "issue": "1", "pages": "62", "issn-l": "1465-9921"}, "abstract": "COVID-19 remains a major public health challenge, requiring the development of tools to improve diagnosis and inform therapeutic decisions. As dysregulated inflammation and coagulation responses have been implicated in the pathophysiology of COVID-19 and sepsis, we studied their plasma proteome profiles to delineate similarities from specific features.\n\nWe measured 276 plasma proteins involved in Inflammation, organ damage, immune response and coagulation in healthy controls, COVID-19 patients during acute and convalescence phase, and sepsis patients; the latter included (i) community-acquired pneumonia (CAP) caused by Influenza, (ii) bacterial CAP, (iii) non-pneumonia sepsis, and (iv) septic shock patients.\n\nWe identified a core response to infection consisting of 42 proteins altered in both COVID-19 and sepsis, although higher levels of cytokine storm-associated proteins were evident in sepsis. Furthermore, microbiologic etiology and clinical endotypes were linked to unique signatures. Finally, through machine learning, we identified biomarkers, such as TRIM21, PTN and CASP8, that accurately differentiated COVID-19 from CAP-sepsis with higher accuracy than standard clinical markers.\n\nThis study extends the understanding of host responses underlying sepsis and COVID-19, indicating varying disease mechanisms with unique signatures. These diagnostic and severity signatures are candidates for the development of personalized management of COVID-19 and sepsis.", "doi": "10.1186/s12931-023-02364-y", "pmid": "36829233", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12931-023-02364-y"}, {"db": "pmc", "key": "PMC9950694"}], "notes": [], "created": "2023-02-27T17:22:27.856Z", "modified": "2023-02-27T17:29:11.649Z"}, {"entity": "publication", "iuid": "845ac1efd1a14178af13474487957dbd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/845ac1efd1a14178af13474487957dbd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/845ac1efd1a14178af13474487957dbd"}}, "title": "Risk factors for impaired respiratory function post COVID-19: A prospective cohort study of nonhospitalized and hospitalized patients.", "authors": [{"family": "Bj\u00f6rsell", "given": "Tove", "initials": "T"}, {"family": "Sundh", "given": "Josefin", "initials": "J"}, {"family": "Lange", "given": "Anna", "initials": "A"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Tevell", "given": "Staffan", "initials": "S"}, {"family": "Blomberg", "given": "Anders", "initials": "A"}, {"family": "Edin", "given": "Alicia", "initials": "A"}, {"family": "Normark", "given": "Johan", "initials": "J", "orcid": "0000-0001-5831-4369", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cab4f084027e4e4b8f0e5113a499e5c6.json"}}, {"family": "Cajander", "given": "Sara", "initials": "S"}], "type": "journal article", "published": "2023-02-23", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null}, "abstract": "Severe COVID-19 increases the risk for long-term respiratory impairment, but data after mild COVID-19 are scarce. Our aims were to determine risk factors for reduced respiratory function 3-6 months after COVID-19 infection and to investigate if reduced respiratory function would relate to impairment of exercise performance and breathlessness.\n\nPatients with COVID-19 were enrolled at the University Hospitals of Ume\u00e5 and \u00d6rebro, and Karlstad Central Hospital, Sweden. Disease severity was defined as mild (nonhospitalized), moderate (hospitalized with or without oxygen treatment), and severe (intensive care). Spirometry, including diffusion capacity (DLCO ), was performed 3-6 months after hospital discharge or study enrollment (for nonhospitalized patients). Breathlessness (defined as \u22651 according to the modified Medical Research Council scale) and functional exercise capacity (1-min sit-to-stand test; 1-MSTST) were assessed.\n\nBetween April 2020 and May 2021, 337 patients were enrolled in the study. Forced vital capacity and DLCO were significantly lower in patients with severe COVID-19. Among hospitalized patients, 20% had reduced DLCO , versus 4% in nonhospitalized. Breathlessness was found in 40.6% of the participants and was associated with impaired DLCO . A pathological desaturation or heart rate response was observed in 17% of participants during the 1-MSTST. However, this response was not associated with reduced DLCO .\n\nReduced DLCO was the major respiratory impairment 3-6 months following COVID-19, with hospitalization as the most important risk factor. The lack of association between impaired DLCO and pathological physiological responses to exertion suggests that these physiological responses are not primarily related to decreased lung function.", "doi": "10.1111/joim.13614", "pmid": "36815689", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-02-27T17:24:16.046Z", "modified": "2023-02-27T17:24:27.993Z"}, {"entity": "publication", "iuid": "b9313c5ab4074c5291baf361990a877c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9313c5ab4074c5291baf361990a877c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9313c5ab4074c5291baf361990a877c"}}, "title": "Inhaled ciclesonide in adults hospitalised with COVID-19: a randomised controlled open-label trial (HALT COVID-19).", "authors": [{"family": "Brodin", "given": "Daniel", "initials": "D"}, {"family": "Tornhammar", "given": "Per", "initials": "P", "orcid": "0000-0003-1043-1894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30bc2420c4c54a65986ab73c60d45def.json"}}, {"family": "Ueda", "given": "Peter", "initials": "P"}, {"family": "Krifors", "given": "Anders", "initials": "A"}, {"family": "Westerlund", "given": "Eli", "initials": "E", "orcid": "0000-0001-5453-1796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06c564d3974f4436bc6c93b94b99eff6.json"}}, {"family": "Athlin", "given": "Simon", "initials": "S"}, {"family": "Wojt", "given": "Sandra", "initials": "S"}, {"family": "Elvstam", "given": "Olof", "initials": "O"}, {"family": "Neumann", "given": "Anca", "initials": "A"}, {"family": "Elshani", "given": "Arsim", "initials": "A"}, {"family": "Giesecke", "given": "Julia", "initials": "J"}, {"family": "Edvardsson-K\u00e4llkvist", "given": "Jens", "initials": "J"}, {"family": "Bunpuckdee", "given": "Sayam", "initials": "S"}, {"family": "Unge", "given": "Christian", "initials": "C"}, {"family": "Larsson", "given": "Martin", "initials": "M"}, {"family": "Johansson", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Ljungberg", "given": "Johan", "initials": "J"}, {"family": "Lindell", "given": "Jonas", "initials": "J"}, {"family": "Hansson", "given": "Johan", "initials": "J"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Andersson", "given": "Daniel Peter", "initials": "DP", "orcid": "0000-0003-4655-4837", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e35f15e626c045c191bd14a522a85c0e.json"}}], "type": "randomized controlled trial", "published": "2023-02-22", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "13", "issue": "2", "pages": "e064374", "issn-l": "2044-6055"}, "abstract": "To assess the efficacy of inhaled ciclesonide in reducing the duration of oxygen therapy (an indicator of time to clinical improvement) among adults hospitalised with COVID-19.\n\nMulticentre, randomised, controlled, open-label trial.\n\n9 hospitals (3 academic hospitals and 6 non-academic hospitals) in Sweden between 1 June 2020 and 17 May 2021.\n\nAdults hospitalised with COVID-19 and receiving oxygen therapy.\n\nInhaled ciclesonide 320 \u00b5g two times a day for 14 days versus standard care.\n\nPrimary outcome was duration of oxygen therapy, an indicator of time to clinical improvement. Key secondary outcome was a composite of invasive mechanical ventilation/death.\n\nData from 98 participants were analysed (48 receiving ciclesonide and 50 receiving standard care; median (IQR) age, 59.5 (49-67) years; 67 (68%) men). Median (IQR) duration of oxygen therapy was 5.5 (3-9) days in the ciclesonide group and 4 (2-7) days in the standard care group (HR for termination of oxygen therapy 0.73 (95% CI 0.47 to 1.11), with the upper 95% CI being compatible with a 10% relative reduction in oxygen therapy duration, corresponding to a <1 day absolute reduction in a post-hoc calculation). Three participants in each group died/received invasive mechanical ventilation (HR 0.90 (95% CI 0.15 to 5.32)). The trial was discontinued early due to slow enrolment.\n\nIn patients hospitalised with COVID-19 receiving oxygen therapy, this trial ruled out, with 0.95 confidence, a treatment effect of ciclesonide corresponding to more than a 1 day reduction in duration of oxygen therapy. Ciclesonide is unlikely to improve this outcome meaningfully.\n\nNCT04381364.", "doi": "10.1136/bmjopen-2022-064374", "pmid": "36813503", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC9950582"}, {"db": "pii", "key": "bmjopen-2022-064374"}, {"db": "ClinicalTrials.gov", "key": "NCT04381364"}], "notes": [], "created": "2023-02-27T17:21:44.921Z", "modified": "2023-02-27T17:21:59.005Z"}, {"entity": "publication", "iuid": "24e7b24a49204215aa186411efb8ad01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24e7b24a49204215aa186411efb8ad01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24e7b24a49204215aa186411efb8ad01"}}, "title": "Attitudes of Swedish Language Twitter Users Toward COVID-19 Vaccination: Exploratory Qualitative Study.", "authors": [{"family": "Beirakdar", "given": "Safwat", "initials": "S", "orcid": "0000-0002-3015-5754", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f74cf5c04b1492790e518ae4b161779.json"}}, {"family": "Klingborg", "given": "Leon", "initials": "L", "orcid": "0000-0002-1662-7890", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/17924357598546489de2acc485c0643f.json"}}, {"family": "Herzig van Wees", "given": "Sibylle", "initials": "S", "orcid": "0000-0002-5270-1170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e2480c5cb4545a0a707cf74fb9a6322.json"}}], "type": "journal article", "published": "2023-02-22", "journal": {"title": "JMIR Infodemiology", "issn": "2564-1891", "volume": "3", "pages": "e42357", "issn-l": null}, "abstract": "Social media have played an important role in shaping COVID-19 vaccine choices during the pandemic. Understanding people's attitudes toward the vaccine as expressed on social media can help address the concerns of vaccine-hesitant individuals.\n\nThe aim of this study was to understand the attitudes of Swedish-speaking Twitter users toward COVID-19 vaccines.\n\nThis was an exploratory qualitative study that used a social media-listening approach. Between January and March 2022, a total of 2877 publicly available tweets in Swedish were systematically extracted from Twitter. A deductive thematic analysis was conducted using the World Health Organization's 3C model (confidence, complacency, and convenience).\n\nConfidence in the safety and effectiveness of the COVID-19 vaccine appeared to be a major concern expressed on Twitter. Unclear governmental strategies in managing the pandemic in Sweden and the belief in conspiracy theories have further influenced negative attitudes toward vaccines. Complacency-the perceived risk of COVID-19 was low and booster vaccination was unnecessary; many expressed trust in natural immunity. Convenience-in terms of accessing the right information and the vaccine-highlighted a knowledge gap about the benefits and necessity of the vaccine, as well as complaints about the quality of vaccination services.\n\nSwedish-speaking Twitter users in this study had negative attitudes toward COVID-19 vaccines, particularly booster vaccines. We identified attitudes toward vaccines and misinformation, indicating that social media monitoring can help policy makers respond by developing proactive health communication interventions.", "doi": "10.2196/42357", "pmid": "37012999", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9996415"}, {"db": "pii", "key": "v3i1e42357"}], "notes": [], "created": "2023-04-19T16:41:04.539Z", "modified": "2023-04-20T17:34:37.417Z"}, {"entity": "publication", "iuid": "db6afbf613f94ad1a97b041a9a9acdde", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db6afbf613f94ad1a97b041a9a9acdde.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db6afbf613f94ad1a97b041a9a9acdde"}}, "title": "Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity.", "authors": [{"family": "Yoshiji", "given": "Satoshi", "initials": "S", "orcid": "0000-0001-8863-2413", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b4aff6c38b244e98d3ba65db57c1637.json"}}, {"family": "Butler-Laporte", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-5388-0396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/529dc69151d3463e8480b975d70fa759.json"}}, {"family": "Lu", "given": "Tianyuan", "initials": "T", "orcid": "0000-0002-5664-5698", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e379dceef0244aa7b76f24294f72c537.json"}}, {"family": "Willett", "given": "Julian Daniel Sunday", "initials": "JDS"}, {"family": "Su", "given": "Chen-Yang", "initials": "CY", "orcid": "0000-0001-6071-4660", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cdedd44e2dbd4723893f827517a64732.json"}}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T", "orcid": "0000-0001-9510-5646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd273e50091d44c3b3e8d1473ce89b0a.json"}}, {"family": "Morrison", "given": "David R", "initials": "DR", "orcid": "0000-0001-8380-3615", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6099e7b5999e486eb486bac1f455fdc1.json"}}, {"family": "Chen", "given": "Yiheng", "initials": "Y"}, {"family": "Liang", "given": "Kevin", "initials": "K"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Ilboudo", "given": "Yann", "initials": "Y"}, {"family": "Afrasiabi", "given": "Zaman", "initials": "Z", "orcid": "0000-0003-4395-5168", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/794e813ab12a49b8b92067ae83a0b8bb.json"}}, {"family": "Lan", "given": "Shanshan", "initials": "S"}, {"family": "Duggan", "given": "Naomi", "initials": "N"}, {"family": "DeLuca", "given": "Chantal", "initials": "C"}, {"family": "Vaezi", "given": "Mitra", "initials": "M"}, {"family": "Tselios", "given": "Chris", "initials": "C"}, {"family": "Xue", "given": "Xiaoqing", "initials": "X"}, {"family": "Bouab", "given": "Meriem", "initials": "M"}, {"family": "Shi", "given": "Fangyi", "initials": "F"}, {"family": "Laurent", "given": "Laetitia", "initials": "L"}, {"family": "M\u00fcnter", "given": "Hans Markus", "initials": "HM", "orcid": "0000-0002-3165-2840", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f3f86c18235456688c86013f19703b4.json"}}, {"family": "Afilalo", "given": "Marc", "initials": "M"}, {"family": "Afilalo", "given": "Jonathan", "initials": "J"}, {"family": "Mooser", "given": "Vincent", "initials": "V", "orcid": "0000-0002-8632-0448", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7af40c95aeaf4dd7ab639b31f773b89a.json"}}, {"family": "Timpson", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0002-7141-9189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90b26df69dcd46bd9f6e4eebbf46a36f.json"}}, {"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "Zhou", "given": "Sirui", "initials": "S"}, {"family": "Forgetta", "given": "Vincenzo", "initials": "V"}, {"family": "Farjoun", "given": "Yossi", "initials": "Y"}, {"family": "Richards", "given": "J Brent", "initials": "JB", "orcid": "0000-0002-3746-9086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8994152547ee4765b1653b834c52a21a.json"}}], "type": "journal article", "published": "2023-02-20", "journal": {"title": "Nat Metab", "issn": "2522-5812", "pages": "1-17", "issn-l": null}, "abstract": "Obesity is a major risk factor for Coronavirus disease (COVID-19) severity; however, the mechanisms underlying this relationship are not fully understood. As obesity influences the plasma proteome, we sought to identify circulating proteins mediating the effects of obesity on COVID-19 severity in humans. Here, we screened 4,907 plasma proteins to identify proteins influenced by body mass index using Mendelian randomization. This yielded 1,216 proteins, whose effect on COVID-19 severity was assessed, again using Mendelian randomization. We found that an s.d. increase in nephronectin (NPNT) was associated with increased odds of critically ill COVID-19 (OR = 1.71, P = 1.63 \u00d7 10-10). The effect was driven by an NPNT splice isoform. Mediation analyses supported NPNT as a mediator. In single-cell RNA-sequencing, NPNT was expressed in alveolar cells and fibroblasts of the lung in individuals who died of COVID-19. Finally, decreasing body fat mass and increasing fat-free mass were found to lower NPNT levels. These findings provide actionable insights into how obesity influences COVID-19 severity.", "doi": "10.1038/s42255-023-00742-w", "pmid": "36805566", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC9940690"}, {"db": "pii", "key": "10.1038/s42255-023-00742-w"}], "notes": [], "created": "2023-02-27T17:28:10.291Z", "modified": "2023-02-27T17:28:10.490Z"}, {"entity": "publication", "iuid": "85d25302102c460dae7b0c13bb3014db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/85d25302102c460dae7b0c13bb3014db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/85d25302102c460dae7b0c13bb3014db"}}, "title": "New Presentation of CD27 Deficiency; Coronary Ectasia and COVID-19.", "authors": [{"family": "Golchehre", "given": "Zahra", "initials": "Z"}, {"family": "Sharafian", "given": "Samin", "initials": "S"}, {"family": "Momtazmanesh", "given": "Nader", "initials": "N"}, {"family": "Chavoshzadeh", "given": "Zahra", "initials": "Z"}, {"family": "Karimi", "given": "Abdollah", "initials": "A"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Kazemi Aghdam", "given": "Maryam", "initials": "M"}, {"family": "Vahidshahi", "given": "Koroush", "initials": "K"}, {"family": "Hashemimoghaddam", "given": "Seyedehatefeh", "initials": "S"}, {"family": "Kosari", "given": "Farid", "initials": "F"}, {"family": "Khafafpour", "given": "Zahra", "initials": "Z"}, {"family": "Shamsian", "given": "Bibi Shahin", "initials": "BS"}, {"family": "Keramatipour", "given": "Mohammad", "initials": "M"}], "type": "journal article", "published": "2023-02-20", "journal": {"title": "Iran J Allergy Asthma Immunol", "issn": "1735-5249", "volume": "22", "issue": "1", "pages": "110-118", "issn-l": null}, "abstract": "CD27 is a costimulatory receptor involved in the maturation of the innate and adaptive immunity. CD27, through interaction with CD70, plays a role in the control of Epstein-Barr virus (EBV) infection. CD27 deficiency leads to an immune dysregulation disease characterized by EBV susceptibility. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might put patients with primary immunodeficiency at risk for adverse outcomes. Chromogenic in situ hybridization (CISH) study was performed to detect EBV in the lymphoma tissue. Genetic analysis of the patient was done with Whole Exome Sequencing and detected variant was confirmed with PCR-Sanger sequencing. Here we report a 20-month-old boy with CD27 deficiency who developed lymphoma and coronary artery ectasia and had been infected with SARS-CoV-2. Clinical and laboratory findings were incompatible with atypical Kawasaki syndrome or multisystem inflammatory syndrome in children (MIS-C). As CD27 deficiency is a rare immune defect, publishing clinical data about the identified patient(s) can shed light on our knowledge about the related phenotype and the spectrum of clinical manifestations associated with CD27 deficiency. Thus, our findings expanded the spectrum of manifestations beyond EBV infection, highlighting this unusual cardiac sequela that could be related to EBV infection, lymphoma, or an underlying disease.", "doi": "10.18502/ijaai.v22i1.12013", "pmid": "37002625", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-04-20T17:41:34.380Z", "modified": "2023-04-20T17:41:34.413Z"}, {"entity": "publication", "iuid": "a2e01bfc1523496fb967631f70974504", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2e01bfc1523496fb967631f70974504.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2e01bfc1523496fb967631f70974504"}}, "title": "Lipid Nanoparticles Deliver the Therapeutic VEGFA mRNA In Vitro and In Vivo and Transform Extracellular Vesicles for Their Functional Extensions.", "authors": [{"family": "Nawaz", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-0792-8296", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/371c4ed4410a443299531a5137b3f51d.json"}}, {"family": "Heydarkhan-Hagvall", "given": "Sepideh", "initials": "S"}, {"family": "Tangruksa", "given": "Benyapa", "initials": "B"}, {"family": "Gonz\u00e1lez-King Garibotti", "given": "Hern\u00e1n", "initials": "H"}, {"family": "Jing", "given": "Yujia", "initials": "Y"}, {"family": "Maugeri", "given": "Marco", "initials": "M"}, {"family": "Kohl", "given": "Franziska", "initials": "F"}, {"family": "Hultin", "given": "Leif", "initials": "L"}, {"family": "Reyahi", "given": "Azadeh", "initials": "A"}, {"family": "Camponeschi", "given": "Alessandro", "initials": "A"}, {"family": "Kull", "given": "Bengt", "initials": "B"}, {"family": "Christoffersson", "given": "Jonas", "initials": "J"}, {"family": "Grimsholm", "given": "Ola", "initials": "O", "orcid": "0000-0003-2064-2556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35635778f5ff488a9e74710bea12541e.json"}}, {"family": "Jennbacken", "given": "Karin", "initials": "K"}, {"family": "Sundqvist", "given": "Martina", "initials": "M", "orcid": "0000-0002-0859-0792", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a430c7ad6be440c78357a4c7f3e59a95.json"}}, {"family": "Wiseman", "given": "John", "initials": "J"}, {"family": "Bidar", "given": "Abdel Wahad", "initials": "AW"}, {"family": "Lindfors", "given": "Lennart", "initials": "L"}, {"family": "Synnergren", "given": "Jane", "initials": "J"}, {"family": "Valadi", "given": "Hadi", "initials": "H", "orcid": "0000-0003-3482-2451", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebbd5ef128eb464b969e08d93c050246.json"}}], "type": "journal article", "published": "2023-02-19", "journal": {"title": "Adv. Sci.", "issn": "2198-3844", "pages": "e2206187", "issn-l": null}, "abstract": "Lipid nanoparticles (LNPs) are currently used to transport functional mRNAs, such as COVID-19 mRNA vaccines. The delivery of angiogenic molecules, such as therapeutic VEGF-A mRNA, to ischemic tissues for producing new blood vessels is an emerging strategy for the treatment of cardiovascular diseases. Here, the authors deliver VEGF-A mRNA via LNPs and study stoichiometric quantification of their uptake kinetics and how the transport of exogenous LNP-mRNAs between cells is functionally extended by cells' own vehicles called extracellular vesicles (EVs). The results show that cellular uptake of LNPs and their mRNA molecules occurs quickly, and that the translation of exogenously delivered mRNA begins immediately. Following the VEGF-A mRNA delivery to cells via LNPs, a fraction of internalized VEGF-A mRNA is secreted via EVs. The overexpressed VEGF-A mRNA is detected in EVs secreted from three different cell types. Additionally, RNA-Seq analysis reveals that as cells' response to LNP-VEGF-A mRNA treatment, several overexpressed proangiogenic transcripts are packaged into EVs. EVs are further deployed to deliver VEGF-A mRNA in vitro and in vivo. Upon equal amount of VEGF-A mRNA delivery via three EV types or LNPs in vitro, EVs from cardiac progenitor cells are the most efficient in promoting angiogenesis per amount of VEGF-A protein produced. Intravenous administration of luciferase mRNA shows that EVs could distribute translatable mRNA to different organs with the highest amounts of luciferase detected in the liver. Direct injections of VEGF-A mRNA (via EVs or LNPs) into mice heart result in locally produced VEGF-A protein without spillover to liver and circulation. In addition, EVs from cardiac progenitor cells cause minimal production of inflammatory cytokines in cardiac tissue compared with all other treatment types. Collectively, the data demonstrate that LNPs transform EVs as functional extensions to distribute therapeutic mRNA between cells, where EVs deliver this mRNA differently than LNPs.", "doi": "10.1002/advs.202206187", "pmid": "36806740", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-02-27T17:27:20.630Z", "modified": "2023-02-27T17:27:20.759Z"}, {"entity": "publication", "iuid": "ac1abbf0ce2948ee94e770dabb6574fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac1abbf0ce2948ee94e770dabb6574fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac1abbf0ce2948ee94e770dabb6574fd"}}, "title": "Differential regulation of mRNA stability modulates transcriptional memory and facilitates environmental adaptation.", "authors": [{"family": "Li", "given": "Bingnan", "initials": "B", "orcid": "0000-0001-8143-4035", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53b7a6990ba146c0a6417e5301261b5a.json"}}, {"family": "Zeis", "given": "Patrice", "initials": "P", "orcid": "0000-0001-7615-2201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df9459746cb14785ae7b8dcc8f90a485.json"}}, {"family": "Zhang", "given": "Yujie", "initials": "Y"}, {"family": "Alekseenko", "given": "Alisa", "initials": "A"}, {"family": "F\u00fcrst", "given": "Eliska", "initials": "E", "orcid": "0000-0001-7101-5347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/239337d0862a43e6b8d202b8614db1bc.json"}}, {"family": "Sanchez", "given": "Yerma Pareja", "initials": "YP"}, {"family": "Lin", "given": "Gen", "initials": "G", "orcid": "0000-0001-9969-8418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3e8e9a47be743a9b14048fc342b671b.json"}}, {"family": "Tekkedil", "given": "Manu M", "initials": "MM"}, {"family": "Piazza", "given": "Ilaria", "initials": "I"}, {"family": "Steinmetz", "given": "Lars M", "initials": "LM"}, {"family": "Pelechano", "given": "Vicent", "initials": "V", "orcid": "0000-0002-9415-788X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce53b4c829e547399014c2d8042dde35.json"}}], "type": "journal article", "published": "2023-02-17", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "910", "issn-l": "2041-1723"}, "abstract": "Transcriptional memory, by which cells respond faster to repeated stimuli, is key for cellular adaptation and organism survival. Chromatin organization has been shown to play a role in the faster response of primed cells. However, the contribution of post-transcriptional regulation is not yet explored. Here we perform a genome-wide screen to identify novel factors modulating transcriptional memory in S. cerevisiae in response to galactose. We find that depletion of the nuclear RNA exosome increases GAL1 expression in primed cells. Our work shows that gene-specific differences in intrinsic nuclear surveillance factor association can enhance both gene induction and repression in primed cells. Finally, we show that primed cells present altered levels of RNA degradation machinery and that both nuclear and cytoplasmic mRNA decay modulate transcriptional memory. Our results demonstrate that mRNA post-transcriptional regulation, and not only transcription regulation, should be considered when investigating gene expression memory.", "doi": "10.1038/s41467-023-36586-x", "pmid": "36801853", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC9936472"}, {"db": "pii", "key": "10.1038/s41467-023-36586-x"}], "notes": [], "created": "2023-02-27T17:25:01.083Z", "modified": "2023-06-19T15:33:33.755Z"}, {"entity": "publication", "iuid": "86d2b7403ad64b9f8ca7e607937227c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86d2b7403ad64b9f8ca7e607937227c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86d2b7403ad64b9f8ca7e607937227c0"}}, "title": "Increasing serum iron levels and their role in the risk of infectious diseases: a Mendelian randomization approach.", "authors": [{"family": "Butler-Laporte", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-5388-0396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/529dc69151d3463e8480b975d70fa759.json"}}, {"family": "Farjoun", "given": "Yossi", "initials": "Y"}, {"family": "Chen", "given": "Yiheng", "initials": "Y"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Liang", "given": "Kevin Y H", "initials": "KYH"}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T", "orcid": "0000-0001-9510-5646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd273e50091d44c3b3e8d1473ce89b0a.json"}}, {"family": "Su", "given": "Chen-Yang", "initials": "CY"}, {"family": "Yoshiji", "given": "Satoshi", "initials": "S"}, {"family": "Forgetta", "given": "Vincenzo", "initials": "V", "orcid": "0000-0002-6061-4720", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/347fc19ca94d4a498fc5b04634046425.json"}}, {"family": "Richards", "given": "J Brent", "initials": "JB", "orcid": "0000-0002-3746-9086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8994152547ee4765b1653b834c52a21a.json"}}], "type": "journal article", "published": "2023-02-11", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "issn-l": "0300-5771"}, "abstract": "Increased iron stores have been associated with elevated risks of different infectious diseases, suggesting that iron supplementation may increase the risk of infections. However, these associations may be biased by confounding or reverse causation. This is important, since up to 19% of the population takes iron supplementation. We used Mendelian randomization (MR) to bypass these biases and estimate the causal effect of iron on infections.\n\nAs instrumental variables, we used genetic variants associated with iron biomarkers in two genome-wide association studies (GWASs) of European ancestry participants. For outcomes, we used GWAS results from the UK Biobank, FinnGen, the COVID-19 Host Genetics Initiative or 23andMe, for seven infection phenotypes: 'any infections', combined, COVID-19 hospitalization, candidiasis, pneumonia, sepsis, skin and soft tissue infection (SSTI) and urinary tract infection (UTI).\n\nMost of our analyses showed increasing iron (measured by its biomarkers) was associated with only modest changes in the odds of infectious outcomes, with all 95% odds ratios confidence intervals within the 0.88 to 1.26 range. However, for the three predominantly bacterial infections (sepsis, SSTI, UTI), at least one analysis showed a nominally elevated risk with increased iron stores (P <0.05).\n\nUsing MR, we did not observe an increase in risk of most infectious diseases with increases in iron stores. However for bacterial infections, higher iron stores may increase odds of infections. Hence, using genetic variation in iron pathways as a proxy for iron supplementation, iron supplements are likely safe on a population level, but we should continue the current practice of conservative iron supplementation during bacterial infections or in those at high risk of developing them.", "doi": "10.1093/ije/dyad010", "pmid": "36773317", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "7034613"}], "notes": [], "created": "2023-02-13T17:59:17.506Z", "modified": "2023-02-13T17:59:27.451Z"}, {"entity": "publication", "iuid": "82fdb9dd967b4b5b9838d495f2cb101b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82fdb9dd967b4b5b9838d495f2cb101b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82fdb9dd967b4b5b9838d495f2cb101b"}}, "title": "Antibiotic use during coronavirus disease 2019 intensive care unit shape multidrug resistance bacteriuria: A Swedish longitudinal prospective study.", "authors": [{"family": "Karlsson", "given": "Philip A", "initials": "PA"}, {"family": "P\u00e4rssinen", "given": "Julia", "initials": "J"}, {"family": "Danielsson", "given": "Erik A", "initials": "EA"}, {"family": "Fatsis-Kavalopoulos", "given": "Nikos", "initials": "N"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}, {"family": "Wang", "given": "Helen", "initials": "H"}], "type": "journal article", "published": "2023-02-07", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "10", "pages": "1087446", "issn-l": null}, "abstract": "High frequency of antimicrobial prescription and the nature of prolonged illness in COVID-19 increases risk for complicated bacteriuria and antibiotic resistance. We investigated risk factors for bacteriuria in the ICU and the correlation between antibiotic treatment and persistent bacteria.\n\nWe conducted a prospective longitudinal study with urine from indwelling catheters of 101 ICU patients from Uppsala University Hospital, Sweden. Samples were screened and isolates confirmed with MALDI-TOF and whole genome sequencing. Isolates were analyzed for AMR using broth microdilution. Clinical data were assessed for correlation with bacteriuria.\n\nLength of stay linearly correlated with bacteriuria (R2 = 0.99, p \u2264 0.0001). 90% of patients received antibiotics, primarily the beta-lactams (76%) cefotaxime, piperacillin-tazobactam, and meropenem. We found high prevalence of Enterococcus (42%) being associated with increased cefotaxime prescription. Antibiotic-susceptible E. coli were found to cause bacteriuria despite concurrent antibiotic treatment when found in co-culture with Enterococcus.\n\nLonger stays in ICUs increase the risk for bacteriuria in a predictable manner. Likely, high use of cefotaxime drives Enterococcus prevalence, which in turn permit co-colonizing Gram-negative bacteria. Our results suggest biofilms in urinary catheters as a reservoir of pathogenic bacteria with the potential to develop and disseminate AMR.", "doi": "10.3389/fmed.2023.1087446", "pmid": "36824610", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC9941185"}], "notes": [], "created": "2023-02-27T17:27:48.653Z", "modified": "2023-02-27T17:27:48.666Z"}, {"entity": "publication", "iuid": "a4366a6d02d248b797694c9f9ecf6fab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a4366a6d02d248b797694c9f9ecf6fab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a4366a6d02d248b797694c9f9ecf6fab"}}, "title": "High prevalence of persistent symptoms and reduced health-related quality of life 6 months after COVID-19.", "authors": [{"family": "Ahmad", "given": "Irma", "initials": "I"}, {"family": "Edin", "given": "Alicia", "initials": "A"}, {"family": "Granvik", "given": "Christoffer", "initials": "C"}, {"family": "Kumm Persson", "given": "Lowa", "initials": "L"}, {"family": "Tevell", "given": "Staffan", "initials": "S"}, {"family": "M\u00e5nsson", "given": "Emeli", "initials": "E"}, {"family": "Magnuson", "given": "Anders", "initials": "A"}, {"family": "Marklund", "given": "Ingela", "initials": "I"}, {"family": "Persson", "given": "Ida-Lisa", "initials": "IL"}, {"family": "Kauppi", "given": "Anna", "initials": "A"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Sundh", "given": "Josefin", "initials": "J"}, {"family": "Lange", "given": "Anna", "initials": "A"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "Normark", "given": "Johan", "initials": "J"}], "type": "multicenter study", "published": "2023-02-02", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "11", "pages": "1104267", "issn-l": "2296-2565"}, "abstract": "The long-term sequelae after COVID-19 constitute a challenge to public health and increased knowledge is needed. We investigated the prevalence of self-reported persistent symptoms and reduced health-related quality of life (HRQoL) in relation to functional exercise capacity, 6 months after infection, and explored risk factors for COVID-19 sequalae.\n\nThis was a prospective, multicenter, cohort study including 434 patients. At 6 months, physical exercise capacity was assessed by a 1-minute sit-to-stand test (1MSTST) and persistent symptoms were reported and HRQoL was evaluated through the EuroQol 5-level 5-dimension (EQ-5D-5L) questionnaire. Patients with both persistent symptoms and reduced HRQoL were classified into a new definition of post-acute COVID syndrome, PACS+. Risk factors for developing persistent symptoms, reduced HRQoL and PACS+ were identified by multivariable Poisson regression.\n\nPersistent symptoms were experienced by 79% of hospitalized, and 59% of non-hospitalized patients at 6 months. Hospitalized patients had a higher prevalence of self-assessed reduced overall health (28 vs. 12%) and PACS+ (31 vs. 11%). PACS+ was associated with reduced exercise capacity but not with abnormal pulse/desaturation during 1MSTST. Hospitalization was the most important independent risk factor for developing persistent symptoms, reduced overall health and PACS+.\n\nPersistent symptoms and reduced HRQoL are common among COVID-19 survivors, but abnormal pulse and peripheral saturation during exercise could not distinguish patients with PACS+. Patients with severe infection requiring hospitalization were more likely to develop PACS+, hence these patients should be prioritized for clinical follow-up after COVID-19.", "doi": "10.3389/fpubh.2023.1104267", "pmid": "36817925", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC9932930"}], "notes": [], "created": "2023-02-27T17:23:53.661Z", "modified": "2023-02-27T17:24:00.330Z"}, {"entity": "publication", "iuid": "01f72b147d9c4d46b6734b4cfb0424d3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01f72b147d9c4d46b6734b4cfb0424d3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01f72b147d9c4d46b6734b4cfb0424d3"}}, "title": "Mental health indicators in Sweden over a 12-month period during the COVID-19 pandemic - Baseline data of the Omtanke2020 Study.", "authors": [{"family": "Lovik", "given": "Anik\u00f3", "initials": "A"}, {"family": "Gonz\u00e1lez-Hij\u00f3n", "given": "Juan", "initials": "J"}, {"family": "K\u00e4hler", "given": "Anna K", "initials": "AK"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Frans", "given": "Emma M", "initials": "EM"}, {"family": "Magnusson", "given": "Patrik K E", "initials": "PKE"}, {"family": "Pedersen", "given": "Nancy L", "initials": "NL"}, {"family": "Hall", "given": "Per", "initials": "P"}, {"family": "Czene", "given": "Kamila", "initials": "K"}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF"}, {"family": "Fang", "given": "Fang", "initials": "F"}], "type": "journal article", "published": "2023-02-01", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "volume": "322", "pages": "108-117", "issn-l": null}, "abstract": "The ongoing COVID-19 pandemic has had an unprecedented impact on the lives of people globally and is expected to have profound effects on mental health. Here we aim to describe the mental health burden experienced in Sweden using baseline data of the Omtanke2020 Study.\n\nWe analysed self-reported, cross-sectional baseline data collected over a 12-month period (June 9, 2020-June 8, 2021) from the Omtanke2020 Study including 27,950 adults in Sweden. Participants were volunteers or actively recruited through existing cohorts and, after providing informed consent, responded to online questionnaires on socio-demographics, mental and physical health, as well as COVID-19 infection and impact. Poisson regression was fitted to assess the relative risk of demonstrating high level symptoms of depression, anxiety, and COVID-19 related distress.\n\nThe proportion of persons with high level of symptoms was 15.6 %, 9.5 % and 24.5 % for depression, anxiety, and COVID-19 specific post-traumatic stress disorder (PTSD), respectively. Overall, 43.4 % of the participants had significant, clinically relevant symptoms for at least one of the three mental health outcomes and 7.3 % had significant symptoms for all three outcomes. We also observed differences in the prevalence of these outcomes across strata of sex, age, recruitment type, COVID-19 status, region, and seasonality.\n\nWhile the proportion of persons with high mental health burden remains higher than the ones reported in pre-pandemic publications, our estimates are lower than previously reported levels of depression, anxiety, and PTSD during the pandemic in Sweden and elsewhere.", "doi": "10.1016/j.jad.2022.11.004", "pmid": "36379324", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Preprint": null}, "xrefs": [{"db": "pmc", "key": "PMC9657895"}, {"db": "pii", "key": "S0165-0327(22)01252-6"}], "notes": [], "created": "2022-11-25T07:24:27.748Z", "modified": "2023-02-13T18:39:15.011Z"}, {"entity": "publication", "iuid": "5fc7d1a35d05441280c6096db20c361d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5fc7d1a35d05441280c6096db20c361d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5fc7d1a35d05441280c6096db20c361d"}}, "title": "Clinical outcomes of myocarditis after SARS-CoV-2 mRNA vaccination in four Nordic countries: population based cohort study.", "authors": [{"family": "Husby", "given": "Anders", "initials": "A", "orcid": "0000-0002-7634-8455", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b55ca3663d44e5b9a3b3beec78d5f2f.json"}}, {"family": "Gulseth", "given": "Hanne L\u00f8vdal", "initials": "HL"}, {"family": "Hovi", "given": "Petteri", "initials": "P"}, {"family": "Hansen", "given": "J\u00f8rgen Vinsl\u00f8v", "initials": "JV"}, {"family": "Pihlstr\u00f6m", "given": "Nicklas", "initials": "N"}, {"family": "Gunnes", "given": "Nina", "initials": "N"}, {"family": "H\u00e4rk\u00e4nen", "given": "Tommi", "initials": "T", "orcid": "0000-0002-4577-1808", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d721ae724cf2493ebb2b7f7ee71c7623.json"}}, {"family": "Dahl", "given": "Jesper", "initials": "J"}, {"family": "Karlstad", "given": "\u00d8ystein", "initials": "\u00d8"}, {"family": "Heli\u00f6", "given": "Tiina", "initials": "T"}, {"family": "K\u00f8ber", "given": "Lars", "initials": "L"}, {"family": "Ljung", "given": "Rickard", "initials": "R", "orcid": "0000-0002-0654-4530", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ba40c2b98b1442192811ba44ffbf967.json"}}, {"family": "Hviid", "given": "Anders", "initials": "A", "orcid": "0000-0002-7509-9127", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de7b6744ea454106afe080326be26390.json"}}], "type": "journal article", "published": "2023-02-01", "journal": {"title": "BMJ Med", "issn": "2754-0413", "volume": "2", "issue": "1", "pages": "e000373", "issn-l": null}, "abstract": "To investigate the clinical outcomes of myocarditis associated with mRNA vaccines against the SARS-CoV-2 virus compared with other types of myocarditis.\n\nPopulation based cohort study.\n\nNationwide register data from four Nordic countries (Denmark, Finland, Norway, and Sweden), from 1 January 2018 to the latest date of follow-up in 2022.\n\nThe Nordic myocarditis cohort; 7292 individuals aged \u226512 years who had an incident diagnosis of myocarditis as a main or secondary diagnosis, in a population of 23 million individuals in Denmark, Finland, Norway, and Sweden.\n\nHeart failure, or death from any cause within 90 days of admission to hospital for new onset myocarditis, and hospital readmission within 90 days of discharge to hospital for new onset myocarditis. Clinical outcomes of myocarditis associated with SARS-CoV-2 mRNA vaccination, covid-19 disease, and conventional myocarditis were compared.\n\nIn 2018-22, 7292 patients were admitted to hospital with new onset myocarditis, with 530 (7.3%) categorised as having myocarditis associated with SARS-CoV-2 mRNA vaccination, 109 (1.5%) with myocarditis associated with covid-19 disease, and 6653 (91.2%) with conventional myocarditis. At the 90 day follow-up, 62, nine, and 988 patients had been readmitted to hospital in each group (vaccination, covid-19, and conventional myocarditis groups, respectively), corresponding to a relative risk of readmission of 0.79 (95% confidence interval 0.62 to 1.00) and 0.55 (0.30 to 1.04) for the vaccination type and covid-19 type myocarditis groups, respectively, compared with the conventional myocarditis group. At the 90 day follow-up, 27, 18, and 616 patients had a diagnosis of heart failure or died in the vaccination type, covid-19 type, and conventional myocarditis groups, respectively. The relative risk of heart failure within 90 days was 0.56 (95% confidence interval 0.37 to 0.85) and 1.48 (0.86 to 2.54) for myocarditis associated with vaccination and covid-19 disease, respectively, compared with conventional myocarditis; the relative risk of death was 0.48 (0.21 to 1.09) and 2.35 (1.06 to 5.19), respectively. Among patients aged 12-39 years with no predisposing comorbidities, the relative risk of heart failure or death was markedly higher for myocarditis associated with covid-19 disease than for myocarditis associated with vaccination (relative risk 5.78, 1.84 to 18.20).\n\nCompared with myocarditis associated with covid-19 disease and conventional myocarditis, myocarditis after vaccination with SARS-CoV-2 mRNA vaccines was associated with better clinical outcomes within 90 days of admission to hospital.", "doi": "10.1136/bmjmed-2022-000373", "pmid": "36936260", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC9978676"}, {"db": "pii", "key": "bmjmed-2022-000373"}], "notes": [], "created": "2023-04-21T16:10:46.840Z", "modified": "2023-04-21T16:10:46.998Z"}, {"entity": "publication", "iuid": "b504cb171e774762b6d6e809b24fa3da", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b504cb171e774762b6d6e809b24fa3da.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b504cb171e774762b6d6e809b24fa3da"}}, "title": "ThermalProGAN: A sequence-based thermally stable protein generator trained using unpaired data.", "authors": [{"family": "Huang", "given": "Hui-Ling", "initials": "HL"}, {"family": "Weng", "given": "Chong-Heng", "initials": "CH"}, {"family": "Nordling", "given": "Torbj\u00f6rn E M", "initials": "TEM"}, {"family": "Liou", "given": "Yi-Fan", "initials": "YF"}], "type": "journal article", "published": "2023-02-00", "journal": {"title": "J Bioinform Comput Biol", "issn": "1757-6334", "volume": "21", "issue": "1", "pages": "2350008", "issn-l": null}, "abstract": "The synthesis of proteins with novel desired properties is challenging but sought after by the industry and academia. The dominating approach is based on trial-and-error inducing point mutations, assisted by structural information or predictive models built with paired data that are difficult to collect. This study proposes a sequence-based unpaired-sample of novel protein inventor (SUNI) to build ThermalProGAN for generating thermally stable proteins based on sequence information.\n\nThe ThermalProGAN can strongly mutate the input sequence with a median number of 32 residues. A known normal protein, 1RG0, was used to generate a thermally stable form by mutating 51 residues. After superimposing the two structures, high similarity is shown, indicating that the basic function would be conserved. Eighty four molecular dynamics simulation results of 1RG0 and the COVID-19 vaccine candidates with a total simulation time of 840[Formula: see text]ns indicate that the thermal stability increased.\n\nThis proof of concept demonstrated that transfer of a desired protein property from one set of proteins is feasible. Availability and implementation: The source code of ThermalProGAN can be freely accessed at https://github.com/markliou/ThermalProGAN/ with an MIT license. The website is https://thermalprogan.markliou.tw:433. Supplementary information: Supplementary data are available on Github.", "doi": "10.1142/S0219720023500087", "pmid": "36999645", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-21T15:50:15.045Z", "modified": "2023-04-21T15:50:15.092Z"}, {"entity": "publication", "iuid": "fdb6539aac004b4c8217f99ec69a600e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fdb6539aac004b4c8217f99ec69a600e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fdb6539aac004b4c8217f99ec69a600e"}}, "title": "The impact of COVID-19 and COVID vaccination on cardiovascular outcomes.", "authors": [{"family": "Akhtar", "given": "Zubair", "initials": "Z"}, {"family": "Trent", "given": "Mallory", "initials": "M"}, {"family": "Moa", "given": "Aye", "initials": "A"}, {"family": "Tan", "given": "Timothy C", "initials": "TC"}, {"family": "Fr\u00f6bert", "given": "Ole", "initials": "O"}, {"family": "MacIntyre", "given": "C Raina", "initials": "CR", "orcid": "0000-0002-3060-0555", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/283c1daa61384999861ce474d0678572.json"}}], "type": "journal article", "published": "2023-02-00", "journal": {"title": "Eur Heart J Suppl", "issn": "1520-765X", "volume": "25", "issue": "Suppl A", "pages": "A42-A49", "issn-l": null}, "abstract": "COVID-19 is an independent risk factor for cardiovascular disease. COVID-19 vaccination may prevent this, but in some cases, COVID-19 vaccination may cause myocarditis or pericarditis. Patients with COVID-19 may present with non-specific symptoms that have a cardiac origin. This review examines the cardiovascular complications of COVID-19 infection and the impact of COVID-19 vaccination. COVID-19 cardiovascular complications include myocardial injury, pericarditis, coagulopathy, myocardial infarction, heart failure, arrhythmias, and persistent post-acute risk of adverse cardiovascular outcomes. Diagnostic and referral pathways for non-specific symptoms, such as dyspnoea and fatigue, remain unclear. COVID-19 vaccination is cardioprotective overall but is associated with myopericarditis in young males, though at a lower rate than following SARS-CoV-2 infection. Increased awareness among primary care physicians of potential cardiovascular causes of non-specific post-COVID-19 symptoms, including in younger adults, such as fatigue, dyspnoea, and chest pain, is essential. We recommend full vaccination with scheduled booster doses, optimal management of cardiovascular risk factors, rapid treatment of COVID-19, and clear diagnostic, referral, and management pathways for patients presenting with non-specific symptoms to rule out cardiac complications.", "doi": "10.1093/eurheartjsupp/suac123", "pmid": "36937372", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10021497"}, {"db": "pii", "key": "suac123"}], "notes": [], "created": "2023-04-21T16:10:28.105Z", "modified": "2023-04-21T16:10:28.161Z"}, {"entity": "publication", "iuid": "98cff7fe9a404ee19184f6f767404caf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/98cff7fe9a404ee19184f6f767404caf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/98cff7fe9a404ee19184f6f767404caf"}}, "title": "SARS-CoV-2 spike HexaPro formulated in aluminium hydroxide and administered in an accelerated vaccination schedule partially protects Syrian Hamsters against viral challenge despite low neutralizing antibody responses.", "authors": [{"family": "Christensen", "given": "Dennis", "initials": "D"}, {"family": "Polacek", "given": "Charlotta", "initials": "C"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Hartmann", "given": "Katrine Top", "initials": "KT"}, {"family": "Jensen", "given": "Henrik Elvang", "initials": "HE"}, {"family": "Zimmermann", "given": "Julie", "initials": "J"}, {"family": "Jungersen", "given": "Gregers", "initials": "G"}, {"family": "Illigen", "given": "Kristin Engelhart", "initials": "KE"}, {"family": "Isling", "given": "Louise Krag", "initials": "LK"}, {"family": "Fernandez-Antunez", "given": "Carlota", "initials": "C"}, {"family": "Ramirez", "given": "Santseharay", "initials": "S"}, {"family": "Bukh", "given": "Jens", "initials": "J"}, {"family": "Pedersen", "given": "Gabriel Kristian", "initials": "GK"}], "type": "journal article", "published": "2023-01-23", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "941281"}, "abstract": "SARS-CoV-2 continues to pose a threat to human health as new variants emerge and thus a diverse vaccine pipeline is needed. We evaluated SARS-CoV-2 HexaPro spike protein formulated in Alhydrogel\u00ae (aluminium oxyhydroxide) in Syrian hamsters, using an accelerated two dose regimen (given 10 days apart) and a standard regimen (two doses given 21 days apart). Both regimens elicited spike- and RBD-specific IgG antibody responses of similar magnitude, but in vitro virus neutralization was low or undetectable. Despite this, the accelerated two dose regimen offered reduction in viral load and protected against lung pathology upon challenge with homologous SARS-CoV-2 virus (Wuhan-Hu-1). This highlights that vaccine-induced protection against SARS-CoV-2 disease can be obtained despite low neutralizing antibody levels and suggests that accelerated vaccine schedules may be used to confer rapid protection against SARS-CoV-2 disease.", "doi": "10.3389/fimmu.2023.941281", "pmid": "36756130", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Funder: H2020": null}, "xrefs": [{"db": "pmc", "key": "PMC9900178"}, {"db": "URL", "key": "https://www.frontiersin.org/articles/10.3389/fimmu.2023.941281/full#supplementary-material", "description": "https://www.frontiersin.org/articles/10.3389/fimmu.2023.941281/full#supplementary-material"}], "notes": [], "created": "2023-02-13T17:53:06.820Z", "modified": "2023-02-13T17:54:54.510Z"}, {"entity": "publication", "iuid": "6263ba1c3fc449cf85ef048c256bf1b8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6263ba1c3fc449cf85ef048c256bf1b8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6263ba1c3fc449cf85ef048c256bf1b8"}}, "title": "Unravelling the link between sleep and mental health during the COVID-19 pandemic.", "authors": [{"family": "Gonz\u00e1lez-Hij\u00f3n", "given": "Juan", "initials": "J"}, {"family": "K\u00e4hler", "given": "Anna K", "initials": "AK"}, {"family": "Frans", "given": "Emma M", "initials": "EM"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Lovik", "given": "Anik\u00f3", "initials": "A", "orcid": "0000-0002-6397-5011", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e50d5a79a1234cd79b22ec2eebf6f410.json"}}], "type": "journal article", "published": "2023-01-17", "journal": {"title": "Stress Health", "issn": "1532-2998", "issn-l": null}, "abstract": "The emergence of COVID-19 brought unparalleled changes in people's lifestyle, including sleep. We aimed to assess the bidirectional association between sleep quality and mental health and describe how sleep and mental health were affected in Sweden during the COVID-19 pandemic (between June 2020 and September 2021). Data were obtained from the Omtanke2020 study. Participants who completed the baseline survey and each of the 8 monthly follow-up surveys were included (N = 9035). We described the distribution of sleep and mental health in the different Swedish regions using maps and over the study period with longitudinal graphs adjusting for sex, age, recruitment type (self-recruitment or invitation), and COVID-19 status. The inner relationships between mental health, sleep and Covid infection were described through relative importance networks. Finally, we modelled how mental health affects sleep and vice versa using generalized estimating equations with different adjustments. Seasonal and north-south regional variations were found in sleep and mental health outcomes at baseline and attenuated over time. The seasonal variation of sleep and mental health correlated moderately with the incidence rate of COVID-19 in the sample. Networks indicate that the relationship between COVID-19 incidence and mental health varies over time. We observed a bidirectional relationship between sleep quality and quantity at baseline and mental health at follow-up and vice versa. Sleep quality and quantity at baseline was associated with adverse symptom trajectories of mental health at follow-up, and vice versa, during the COVID-19 pandemic. There was also a weak relationship between COVID-19 incidence, sleep, and mental health.", "doi": "10.1002/smi.3223", "pmid": "36649144", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2023-02-13T18:38:35.800Z", "modified": "2023-02-13T18:38:35.856Z"}, {"entity": "publication", "iuid": "13722195d5c8437dbbf2df53eb0ded2e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13722195d5c8437dbbf2df53eb0ded2e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13722195d5c8437dbbf2df53eb0ded2e"}}, "title": "How Sweden approached the COVID-19 pandemic: Summary and commentary on the National Commission Inquiry.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF", "orcid": "0000-0003-1024-5602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1d5e45881a7469ca20a0eb360d891cc.json"}}], "type": "journal article", "published": "2023-01-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": "112", "issue": "1", "pages": "19-33", "issn-l": "0803-5253"}, "abstract": "Sweden initially chose a different disease prevention and control path during the pandemic than many other European countries. In June 2020, the Swedish Government established a National Commission to examine the management of COVID-19 in Sweden. This paper summarises, and discusses, its findings.\n\nThree reports published by the Commission were analysed. The first focused on the care of older people during the pandemic. The second examined disease and infection transmission and control and health care and public health. The third updated the first two reports and also covered economic aspects, crisis management and public communication.\n\nBy 25 February 2022, when the final report was published, 15 800 individuals, 1.5 per 1000 Swedish inhabitants, had died after COVID-19. The death rates were high in spring 2020, but overall excess mortality in 2020-2021 was +0.79%, which was lower than in many other European countries. The Commission suggested that the voluntary measures that were adopted were appropriate and maintained Swedes' personal freedom during the pandemic. However, more extensive and earlier measures should have been taken, especially during the first wave.\n\nThe Swedish COVID-19 Commission felt that earlier and more extensive pandemic action should have been taken, particularly during the first wave.", "doi": "10.1111/apa.16535", "pmid": "36065136", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC9538368"}], "notes": [], "created": "2023-01-13T13:25:04.669Z", "modified": "2023-07-13T11:27:39.751Z"}, {"entity": "publication", "iuid": "c407248f73de4d6e942cd708071d48be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c407248f73de4d6e942cd708071d48be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c407248f73de4d6e942cd708071d48be"}}, "title": "Specific Physiotherapy for Persons in the Post-Acute Phase after Moderate-To-Severe COVID-19: An Experimental Multiple-Baseline Single-Case Study", "authors": [{"family": "Azzabi", "given": "Susann", "initials": "S"}, {"family": "Jones", "given": "Christine", "initials": "C"}, {"family": "S\u00f6derlund", "given": "Anne", "initials": "A"}, {"family": "Nordgren", "given": "Lena", "initials": "L"}], "type": "posted-content", "published": "2023-00-00", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.2139/ssrn.4441260", "pmid": null, "labels": {"Category: Social Science & Humanities": null, "Type: Preprint": null, "Category: Rehabilitation": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:09:58.825Z", "modified": "2023-10-04T06:27:31.281Z"}, {"entity": "publication", "iuid": "a389b5e780ef4cd6b27bcd9c402dd4b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a389b5e780ef4cd6b27bcd9c402dd4b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a389b5e780ef4cd6b27bcd9c402dd4b9"}}, "title": "Mortality in Norway and Sweden During the COVID-19 Pandemic 2020 \u2013 22: A Comparative Study", "authors": [{"family": "Zahl", "given": "Per Henrik", "initials": "PH"}, {"family": "Hemstr\u00f6m", "given": "\u00d6rjan", "initials": "\u00d6"}, {"family": "Johansen", "given": "Rune", "initials": "R"}, {"family": "Mamalund", "given": "Svenn Erik", "initials": "SE"}], "type": "posted-content", "published": "2023-00-00", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.2139/ssrn.4449686", "pmid": null, "labels": {"Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:08:36.783Z", "modified": "2023-10-04T05:16:03.167Z"}, {"entity": "publication", "iuid": "2d56c9b15d764223911a21487cb759e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d56c9b15d764223911a21487cb759e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d56c9b15d764223911a21487cb759e2"}}, "title": "Mitigating Oil Price Volatility Amidst the COVID-19 Pandemic: Leveraging Metal Hedging Strategies with Market Uncertainty", "authors": [{"family": "Hussain", "given": "Saddam", "initials": "S"}, {"family": "Hussain", "given": "Sajid", "initials": "S"}], "type": "posted-content", "published": "2023-00-00", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.2139/ssrn.4515282", "pmid": null, "labels": {"Type: Preprint": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:09:37.410Z", "modified": "2023-10-04T12:59:12.155Z"}, {"entity": "publication", "iuid": "58ba0c3206a0408790805f45ada75fc7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/58ba0c3206a0408790805f45ada75fc7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/58ba0c3206a0408790805f45ada75fc7"}}, "title": "Differential Immunometabolism and Tissue Responses to Delta and Omicron SARS-CoV-2 Variants in Golden Syrian Hamster Models", "authors": [{"family": "Rajaiah", "given": "Rajesh", "initials": "R"}, {"family": "Pandey", "given": "Kabita", "initials": "K"}, {"family": "Ambikan", "given": "Anoop T", "initials": "AT"}, {"family": "Kumar", "given": "Narendra", "initials": "N"}, {"family": "Guda", "given": "Reema", "initials": "R"}, {"family": "Montaner", "given": "Luis", "initials": "L"}, {"family": "Cohen", "given": "Samuel M", "initials": "SM"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}, {"family": "Byrareddy", "given": "Siddappa", "initials": "S"}], "type": "posted-content", "published": "2023-00-00", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.2139/ssrn.4554600", "pmid": null, "labels": {"Type: Preprint": null, "Category: Other": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:55:21.475Z", "modified": "2023-10-06T10:51:17.531Z"}, {"entity": "publication", "iuid": "e251a5b1eb9c4da29ae1ac53e88d79d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e251a5b1eb9c4da29ae1ac53e88d79d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e251a5b1eb9c4da29ae1ac53e88d79d5"}}, "title": "Dexamethasone Treatment for COVID-19 is Related with Increased Mortality in Haematological Malignancy Patients: Results from the EPICOVIDEHA Registry", "authors": [{"family": "Aiello", "given": "Tommaso Francesco", "initials": "TF"}, {"family": "Salmanton-Garcia", "given": "Jon", "initials": "J"}, {"family": "Marchesi", "given": "Francesco", "initials": "F"}, {"family": "Weinbergerova", "given": "Barbora", "initials": "B"}, {"family": "Glenthoj", "given": "Andreas", "initials": "A"}, {"family": "Van Praet", "given": "Jens", "initials": "J"}, {"family": "Farina", "given": "Francesca", "initials": "F"}, {"family": "Davila-Valls", "given": "Julio", "initials": "J"}, {"family": "Mart\u00edn-P\u00e9rez", "given": "Sonia", "initials": "S"}, {"family": "El-Ashwah", "given": "Shaimaa", "initials": "S"}, {"family": "Sch\u00f6nlein", "given": "Martin", "initials": "M"}, {"family": "Falces-Romero", "given": "Iker", "initials": "I"}, {"family": "Labrador", "given": "Jorge", "initials": "J"}, {"family": "Sili", "given": "Uluhan", "initials": "U"}, {"family": "Buquicchio", "given": "Caterina", "initials": "C"}, {"family": "Vena", "given": "Antonio", "initials": "A"}, {"family": "Plantefeve", "given": "Gaetan", "initials": "G"}, {"family": "Petzer", "given": "Verena", "initials": "V"}, {"family": "Biernat", "given": "Monika M", "initials": "MM"}, {"family": "Lahmer", "given": "Tobias", "initials": "T"}, {"family": "Espigado", "given": "Ildefonso", "initials": "I"}, {"family": "van Doesum", "given": "Jaap A", "initials": "JA"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Piukovics", "given": "Kl\u00e1ra", "initials": "K"}, {"family": "Tascini", "given": "Carlo", "initials": "C"}, {"family": "Samarkos", "given": "Michael", "initials": "M"}, {"family": "Bilgin", "given": "Yavuz M", "initials": "YM"}, {"family": "Fianchi", "given": "Luana", "initials": "L"}, {"family": "Itri", "given": "Federico", "initials": "F"}, {"family": "Valkovic", "given": "Toni", "initials": "T"}, {"family": "Fracchiolla", "given": "Nicola S", "initials": "NS"}, {"family": "Dargenio", "given": "Michelina", "initials": "M"}, {"family": "Jimenez", "given": "Moraima", "initials": "M"}, {"family": "Magyari", "given": "Ferenc", "initials": "F"}, {"family": "Lopez-Garcia", "given": "Alberto", "initials": "A"}, {"family": "Prezioso", "given": "Lucia", "initials": "L"}, {"family": "\u010colovic", "given": "Natasa", "initials": "N"}, {"family": "Shumilov", "given": "Evgenii", "initials": "E"}, {"family": "Abu-Zeinah", "given": "Ghaith", "initials": "G"}, {"family": "Lavilla-Rubira", "given": "Esperanza", "initials": "E"}, {"family": "Papa", "given": "Mario Virgilio", "initials": "MV"}, {"family": "Lopez-Gonzalez", "given": "Tom\u00e1s Jos\u00e9", "initials": "TJ"}, {"family": "Pinczes", "given": "L\u00e1szl\u00f3 Imre", "initials": "LI"}, {"family": "Demirkan", "given": "Fatih", "initials": "F"}, {"family": "Ali", "given": "Natasha", "initials": "N"}, {"family": "Besson", "given": "Caroline", "initials": "C"}, {"family": "Fouquet", "given": "Guillemette", "initials": "G"}, {"family": "Romano", "given": "Alessandra", "initials": "A"}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jose Angel", "initials": "JA"}, {"family": "del Principe", "given": "Maria Ilaria", "initials": "MI"}, {"family": "Aujayeb", "given": "Avinash", "initials": "A"}, {"family": "Merelli", "given": "Maria", "initials": "M"}, {"family": "Lamure", "given": "Sylvain", "initials": "S"}, {"family": "Marques De Almeida", "given": "Joyce", "initials": "J"}, {"family": "Gomes da Silva", "given": "Maria", "initials": "M"}, {"family": "Eisa", "given": "Noha", "initials": "N"}, {"family": "Meletiadis", "given": "Joseph", "initials": "J"}, {"family": "Rinaldi", "given": "Ikhwan", "initials": "I"}, {"family": "Finizio", "given": "Olimpia", "initials": "O"}, {"family": "Jak\u0161i\u0107", "given": "Ozren", "initials": "O"}, {"family": "Delia", "given": "Mario", "initials": "M"}, {"family": "Nizamuddin", "given": "Summiya", "initials": "S"}, {"family": "Marchetti", "given": "Monia", "initials": "M"}, {"family": "Machado", "given": "Marina", "initials": "M"}, {"family": "Cernan", "given": "Martin", "initials": "M"}, {"family": "Coppola", "given": "Nicola", "initials": "N"}, {"family": "Gavriilaki", "given": "Eleni", "initials": "E"}, {"family": "Cattaneo", "given": "Chiara", "initials": "C"}, {"family": "Groh", "given": "Ana", "initials": "A"}, {"family": "Stojanoski", "given": "Zlate", "initials": "Z"}, {"family": "Erben", "given": "Nurettin", "initials": "N"}, {"family": "Pantic", "given": "Nikola", "initials": "N"}, {"family": "Mendez", "given": "Gustavo Adolfo", "initials": "GA"}, {"family": "Di Blasi", "given": "Roberta", "initials": "R"}, {"family": "Meers", "given": "Stef", "initials": "S"}, {"family": "De Ramon", "given": "Cristina", "initials": "C"}, {"family": "Bahr", "given": "Nathan C", "initials": "NC"}, {"family": "Emarah", "given": "Ziad", "initials": "Z"}, {"family": "Varricchio", "given": "Gina", "initials": "G"}, {"family": "Cvetanoski", "given": "Milche", "initials": "M"}, {"family": "Garcia-Sanz", "given": "Ram\u00f3n", "initials": "R"}, {"family": "Mitrovic", "given": "Mirjana", "initials": "M"}, {"family": "Lievin", "given": "Rapha\u00ebl", "initials": "R"}, {"family": "Hanakova", "given": "Michaela", "initials": "M"}, {"family": "Racil", "given": "Zden\u011bk", "initials": "Z"}, {"family": "Vehreschild", "given": "Maria", "initials": "M"}, {"family": "Tragiannidis", "given": "Athanasios", "initials": "A"}, {"family": "Nunes Rodrigues", "given": "Raquel", "initials": "R"}, {"family": "Garcia-Bordallo", "given": "Daniel", "initials": "D"}, {"family": "Cordoba", "given": "Raul", "initials": "R"}, {"family": "Cabirta", "given": "Alba", "initials": "A"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Ammatuna", "given": "Emanuele", "initials": "E"}, {"family": "Arellano", "given": "Elena", "initials": "E"}, {"family": "Wolf", "given": "Dominik", "initials": "D"}, {"family": "Prin", "given": "Romane", "initials": "R"}, {"family": "Limongelli", "given": "Alessandro", "initials": "A"}, {"family": "Bavastro", "given": "Martina", "initials": "M"}, {"family": "\u00c7olak", "given": "G\u00f6k\u00e7e Melis", "initials": "GM"}, {"family": "Grafe", "given": "Stefanie K", "initials": "SK"}, {"family": "Hersby", "given": "Ditte Stampe", "initials": "DS"}, {"family": "Rahimli", "given": "Laman", "initials": "L"}, {"family": "Cornely", "given": "Oliver A", "initials": "OA"}, {"family": "Garcia-Vidal", "given": "Carolina", "initials": "C"}, {"family": "Pagano", "given": "Livio", "initials": "L"}], "type": "posted-content", "published": "2023-00-00", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.2139/ssrn.4473151", "pmid": null, "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:31:55.616Z", "modified": "2023-10-04T10:58:26.841Z"}, {"entity": "publication", "iuid": "2984715e091b41cca10d0afc09010d9d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2984715e091b41cca10d0afc09010d9d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2984715e091b41cca10d0afc09010d9d"}}, "title": "Critical Flows Throughout the Covid-19 Pandemic \u2013 a Longitudinal Study on Interdependencies and Resilience in a Swedish Context", "authors": [{"family": "Lindstr\u00f6m M\u00e5nefjord", "given": "Josefin", "initials": "J"}, {"family": "Johansson", "given": "Jonas", "initials": "J"}], "type": "posted-content", "published": "2023-00-00", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.2139/ssrn.4510064", "pmid": null, "labels": {"Category: Other": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:09:32.247Z", "modified": "2023-10-04T12:56:33.856Z"}, {"entity": "publication", "iuid": "44df84b7a2b14cd399c660a2dcc50182", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44df84b7a2b14cd399c660a2dcc50182.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44df84b7a2b14cd399c660a2dcc50182"}}, "title": "Morphological changes without histological myocarditis in hearts of COVID-19 deceased patients", "authors": [{"family": "Razaghi", "given": "Ali", "initials": "A"}, {"family": "Szakos", "given": "Attila", "initials": "A"}, {"family": "Al-Shakarji", "given": "Riham", "initials": "R"}, {"family": "Bj\u00f6rnstedt", "given": "Mikael", "initials": "M"}, {"family": "Szekely", "given": "Laszlo", "initials": "L"}], "type": "journal-article", "published": "2022-12-31", "journal": {"title": "Scandinavian Cardiovascular Journal", "issn": "1401-7431", "volume": "56", "issue": "1", "pages": "166-173", "issn-l": null}, "abstract": "Objective. Patients with underlying heart diseases have a higher risk of dying from Covid-19. It has also been suggested that Covid-19 affects the heart through myocarditis. Despite the rapidly growing research on the management of Covid-19 associated complications, most of the ongoing research is focused on the respiratory complications of Covid-19, and little is known about the prevalence of myocarditis. Design. This study aimed to characterize myocardial involvement by using a panel of antibodies to detect hypoxic and inflammatory changes and the presence of SARS-CoV-2 proteins in heart tissues obtained during the autopsy procedure of Covid-19 deceased patients. Thirty-seven fatal COVID-19 cases and 21 controls were included in this study. Results. Overall, the Covid-19 hearts had several histopathological changes like the waviness of myocytes, fibrosis, contract band necrosis, infiltration of polymorphonuclear neutrophils, vacuolization, and necrosis of myocytes. In addition, endothelial damage and activation were detected in heart tissue. However, viral replication was not detected using RNA in situ hybridization. Also, lymphocyte infiltration, as a hallmark of myocarditis, was not seen in this study. Conclusion. No histological sign of myocarditis was detected in any of our cases; our findings are thus most congruent with the hypothesis of the presence of a circulating endothelium activating factor such as VEGF, originating outside of the heart, probably from the hypoxic part of the Covid-19 lungs.", "doi": "10.1080/14017431.2022.2085320", "pmid": "35678649", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-20T19:29:44.814Z", "modified": "2022-08-19T06:01:01.560Z"}, {"entity": "publication", "iuid": "91d6e059b7e14aab921dec6d04124589", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/91d6e059b7e14aab921dec6d04124589.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/91d6e059b7e14aab921dec6d04124589"}}, "title": "Burden of vaccine-preventable diseases, trends in vaccine coverage and current challenges in the implementation of the expanded program on immunization: A situation analysis of Cameroon.", "authors": [{"family": "Ngwa", "given": "Che Henry", "initials": "CH", "orcid": "0000-0003-1984-7909", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/994a7153e4de4496ace403a940cb7fb5.json"}}, {"family": "Doungtsop", "given": "Brigitte-Carole Keumatio", "initials": "BK"}, {"family": "Bihnwi", "given": "Rengerline", "initials": "R"}, {"family": "Ngo", "given": "Ngo Valery", "initials": "NV"}, {"family": "Yang", "given": "Niendum Mediatrice", "initials": "NM"}], "type": "journal article", "published": "2022-12-31", "journal": {"title": "Hum Vaccin Immunother", "issn": "2164-554X", "issn-l": null, "volume": "18", "issue": "1", "pages": "1939620"}, "abstract": "The discovery and development of vaccines remain one of the major successes of global health with millions of lives saved every year through routine vaccination. Although vaccines provide a safe and cost-effective solution to vaccine-preventable diseases (VPDs), VPDs are still a serious public health problem in most parts of the world, especially in sub-Saharan Africa (SSA) and Asia. In this review, we discuss the burden of VPDs and vaccine coverage several decades after the introduction of the Expanded Program on Immunization (EPI) in Cameroon. We also discuss how different factors affect the implementation of the EPI, highlighting context-specific factors such as the ongoing civil conflict in Cameroon, and the presence of other infectious diseases like COVID-19.", "doi": "10.1080/21645515.2021.1939620", "pmid": "34197271", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8920166"}], "notes": [], "created": "2021-07-05T14:32:04.699Z", "modified": "2023-06-19T15:16:12.262Z"}, {"entity": "publication", "iuid": "1ffb34167f6b46bdb4027e74167a09c7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ffb34167f6b46bdb4027e74167a09c7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ffb34167f6b46bdb4027e74167a09c7"}}, "title": "Sweden's Pandemic Experiment", "authors": [{"family": "Bergmans", "given": "S", "initials": "S"}, {"family": "Lindstr\u00f6m", "given": "M", "initials": "M"}], "type": null, "published": "2022-12-19", "journal": {"title": null, "issn": "ISBN 9781032266718", "issn-l": null, "volume": null, "issue": null, "pages": "322"}, "abstract": "This book considers Sweden\u2019s pandemic management which differed so significantly from much of the rest of the world: it provoked intense and wide-reaching interest, curiosity and criticism. Trans-disciplinary Swedish authors from the humanities, life sciences, social sciences, and cultural studies use a variety of tools to mine deeper into some of the central elements and dimensions in their country\u2019s pandemic management such as understandings of freedom, the execution of power, denialism, exceptionalism, patriotism, the role of expertise and trust in the national state to give a deeper understanding of Sweden\u2019s decisions, failures, successes, and the lessons to be learned.\r\nAimed at readers with interest in global health and politics it will also be of interest in disciplines such as virology,epidemiology, history, cultural studies, ethics, media studies, medicine and economics.\r\nThe Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives.", "doi": "https://doi.org/10.4324/9781003289364", "pmid": null, "labels": {"Type: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-01-16T15:35:40.815Z", "modified": "2023-02-23T06:16:16.600Z"}, {"entity": "publication", "iuid": "3bbafb7e92c0416d8fb72a56545e31c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3bbafb7e92c0416d8fb72a56545e31c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3bbafb7e92c0416d8fb72a56545e31c5"}}, "title": "Re-evaluating Our Knowledge of Health System Resilience During COVID-19: Lessons From the First Two Years of the Pandemic.", "authors": [{"family": "Saulnier", "given": "Dell D", "initials": "DD", "orcid": "0000-0001-7761-0737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d3fc961101845b1ae844339af7495e4.json"}}, {"family": "Duchenko", "given": "Anna", "initials": "A"}, {"family": "Ottilie-Kovelman", "given": "Sierra", "initials": "S"}, {"family": "Tediosi", "given": "Fabrizio", "initials": "F", "orcid": "0000-0001-8671-9400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9884188f9c04312b05212ade939818d.json"}}, {"family": "Blanchet", "given": "Karl", "initials": "K", "orcid": "0000-0003-0498-8020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aad004843f3f44c8b011feedf86831e1.json"}}], "type": "review", "published": "2022-12-06", "journal": {"title": "Int J Health Policy Manag", "issn": "2322-5939", "issn-l": null, "volume": "12", "issue": null, "pages": "6659"}, "abstract": "Health challenges like coronavirus disease 2019 (COVID-19) are becoming increasingly complex, transnational, and unpredictable. Studying health system responses to the COVID-19 pandemic is an opportunity to enhance our understanding of health system resilience and establish a clearer link between theoretical concepts and practical ideas on how to build resilience.\r\n\r\nThis narrative literature review aims to address four questions using a health system resilience framework: (i) What do we understand about the dimensions of resilience? (ii) What aspects of the resilience dimensions remain uncertain? (iii) What aspects of the resilience dimensions are missing from the COVID-19 discussions? and (iv) What has COVID-19 taught us about resilience that is missing from the framework? A scientific literature database search was conducted in December 2020 and in April 2022 to identify publications that discussed health system resilience in relation to COVID-19, excluding articles on psychological and other types of resilience. A total of 63 publications were included.\r\n\r\nThere is good understanding around information sharing, flexibility and good leadership, learning, maintaining essential services, and the need for legitimate, interdependent systems. Decision-making, localized trust, influences on interdependence, and transformation remain uncertain. Vertical interdependence, monitoring risks beyond the health system, and consequences of changes on the system were not discussed. Teamwork, actor legitimacy, values, inclusivity, trans-sectoral resilience, and the role of the private sector are identified as lessons from COVID-19 that should be further explored for health system resilience.\r\n\r\nKnowledge of health system resilience has continued to cohere following the pandemic. The eventual consequences of system changes and the resilience of subsystems are underexplored. Through governance, the concept of health system resilience can be linked to wider issues raised by the pandemic, like inclusivity. Our findings show the utility of resilience theory for strengthening health systems for crises and the benefit of continuing to refine existing resilience theory.", "doi": "10.34172/ijhpm.2022.6659", "pmid": "37579465", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC10125099"}, {"db": "pii", "key": "6659"}], "notes": [], "created": "2023-10-05T08:26:23.977Z", "modified": "2023-10-06T04:58:17.047Z"}, {"entity": "publication", "iuid": "b3e56804818b4607b3846fdce98963cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b3e56804818b4607b3846fdce98963cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b3e56804818b4607b3846fdce98963cc"}}, "title": "Effectiveness of COVID-19 Vaccines over 13 Months Covering the Period of the Emergence of the Omicron Variant in the Swedish Population.", "authors": [{"family": "Xu", "given": "Yiyi", "initials": "Y", "orcid": "0000-0001-9106-0049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06663aac11174e88a79cbb8e2ec4f3c0.json"}}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Kirui", "given": "Brian", "initials": "B", "orcid": "0000-0002-6656-6029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b22b96547b344c79b3780723af1f30e0.json"}}, {"family": "Santosa", "given": "Ailiana", "initials": "A", "orcid": "0000-0002-1848-2867", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/049cb4da029a4e7491b6914f93e8bf17.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}, {"family": "Leach", "given": "Susannah", "initials": "S", "orcid": "0000-0002-9614-2753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18d00be831d241dca238b3253d1b45f6.json"}}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW", "orcid": "0000-0002-4387-4096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bb5d1f761ef48c4837ed4f984717f0e.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2022-12-05", "journal": {"title": "Vaccines", "issn": "2076-393X", "issn-l": null, "volume": "10", "issue": "12", "pages": null}, "abstract": "We estimated real-world vaccine effectiveness (VE) against COVID-19 infection, hospitalization, ICU admission, and death up to 13 months after vaccination. VE before and after the emergence of Omicron was investigated.\r\n\r\nWe used registered data from the entire Swedish population above age 12 (n = 9,153,456). Cox regression with time-varying exposure was used to estimate weekly/monthly VE against COVID-19 outcomes from 27 December 2020 to 31 January 2022. The analyses were stratified by age, sex, and vaccine type (BNT162b2, mRNA-1273, and AZD1222).\r\n\r\nTwo vaccine doses offered good long-lasting protection against infection before Omicron (VE were above 85% for all time intervals) but limited protection against Omicron infection (dropped to 43% by week four and no protection by week 14). For severe COVID-19 outcomes, higher VE was observed during the entire follow-up period. Among individuals above age 65, the mRNA vaccines showed better VE against infection than AZD1222 but similar high VE against hospitalization.\r\n\r\nOur findings provide strong evidence for long-term maintained protection against severe COVID-19 by the basic two-dose schedule, supporting more efforts to encourage unvaccinated persons to get the basic two doses, and encourage vaccinated persons to get a booster to ensure better population-level protection.", "doi": "10.3390/vaccines10122074", "pmid": "36560484", "labels": {"Category: Omicron VoC": null, "Category: Vaccines": null, "Category: Health": null, "Type: Journal article": null, "Research Area: Vaccine": null, "Funder: KAW/SciLifeLab": null, "Topics: Register-based research": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC9782222"}, {"db": "pii", "key": "vaccines10122074"}], "notes": [], "created": "2023-01-11T07:10:07.512Z", "modified": "2023-01-13T10:03:13.606Z"}, {"entity": "publication", "iuid": "e9d5aabd4b404ca2a149b7d83644bbc2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e9d5aabd4b404ca2a149b7d83644bbc2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e9d5aabd4b404ca2a149b7d83644bbc2"}}, "title": "Dying during the COVID-19 Pandemic in Sweden: Relatives' Experiences of End-of-Life Care (the CO-LIVE Study).", "authors": [{"family": "Hedman", "given": "Christel", "initials": "C", "orcid": "0000-0003-4183-7598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f207650ce40e46e5b3ab9d7b716684e7.json"}}, {"family": "F\u00fcrst", "given": "Carl Johan", "initials": "CJ"}, {"family": "Rasmussen", "given": "Birgit H", "initials": "BH", "orcid": "0000-0003-0830-6058", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb3b0176d4654420acbc791974c7cb36.json"}}, {"family": "van der Heide", "given": "Agnes", "initials": "A"}, {"family": "Schelin", "given": "Maria E C", "initials": "MEC"}], "type": "journal article", "published": "2022-12-02", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "23", "issn-l": null}, "abstract": "The COVID-19 pandemic has seen many deaths, but the majority were for causes other than COVID-19. However, end-of-life care in all settings has been affected by measures limiting the spread of the virus, for patients with and without COVID-19. The Swedish coronavirus strategy was different compared to many other countries, which might have affected end-of-life care. The aim was to describe the experiences of end-of-life care for bereaved relatives in Sweden during the \"first wave\" and to compare the experiences for deaths due to COVID-19 with the experiences for deaths for other reasons.\n\nA random sample of addresses for 2400 people who died during March-September 2020 was retrieved from the Swedish Person Address Registry. Relatives were contacted with a questionnaire regarding their experience of end-of-life care, with a focus on communication, participation, and trust.\n\nIn total, 587 relatives (25% response rate) answered the questionnaire (14% COVID-19-deaths, 65% non-COVID-19-deaths, 21% uncertain). In the COVID-19 group 28% of the relatives were allowed visits without restrictions compared to 60% in the non-COVID-19 group (p &lt; 0.01). Only 28% of the relatives in the COVID-19 group reported that the person received \"enough care from physicians\", significantly fewer than the non-COVID group (65%, p &lt; 0.01).\n\nRelatives' experience of end-of-life care for persons with COVID-19 was significantly worse than relatives of persons without COVID-19, but relatives for persons without COVID-19 were also negatively affected.", "doi": "10.3390/ijerph192316146", "pmid": "36498221", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9740982"}, {"db": "pii", "key": "ijerph192316146"}], "notes": [], "created": "2023-01-13T13:30:38.545Z", "modified": "2023-01-13T13:30:38.625Z"}, {"entity": "publication", "iuid": "01d0dfdb226e48828101c520ca11852b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01d0dfdb226e48828101c520ca11852b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01d0dfdb226e48828101c520ca11852b"}}, "title": "The significance of the COVID-19 pandemic for family caregivers of non-COVID-19 patients in need of specialized palliative care at home: a qualitative study.", "authors": [{"family": "Wind", "given": "Gitte", "initials": "G", "orcid": "0000-0002-4907-4225", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59fa80d82c57425cb5654bae8f943cbf.json"}}, {"family": "Vedsegaard", "given": "Helle Wendner", "initials": "HW", "orcid": "0000-0003-0642-0877", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc7be809bef544df89b4aaab46a2de36.json"}}, {"family": "Marsaa", "given": "Kristoffer", "initials": "K", "orcid": "0000-0001-7366-7533", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fb03be244644237ba3eb1a308b13e9d.json"}}, {"family": "True", "given": "Trine Solander", "initials": "TS", "orcid": "0000-0003-4778-3340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ea4a7e652b146fb8949ee69454cca77.json"}}, {"family": "Konradsen", "given": "Hanne", "initials": "H", "orcid": "0000-0002-7477-125X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b462d15cdeec4dcb8371e07cf2e97853.json"}}], "type": "journal article", "published": "2022-12-00", "journal": {"title": "Int J Qual Stud Health Well-being", "issn": "1748-2631", "volume": "17", "issue": "1", "pages": "2113021", "issn-l": null}, "abstract": "It is well known that being a family caregiver of a palliative patient in general is rewarding as well as burdensome. The COVID-19 pandemic may have exacerbated this situation. We therefore explored the significance of the COVID-19 pandemic for family caregivers of non-COVID-19 patients in need of specialized palliative care at home.\n\nOpen-ended, semi-structured telephone interviews were conducted with 15 family caregivers of patients treated by a specialized palliative outpatient unit in a Danish hospital. Interviews were analysed using inductive thematic analysis.\n\nFour themes concerning the significance of the COVID-19 pandemic were identified: 1) being a family caregiver of a patient whose lifespan is already limited, 2) dealing with the risk of passing on COVID-19 oneself, 3) dealing with the risk of others passing on COVID-19 to the patient at home, and 4) living with modified specialized palliative care.\n\nThe COVID-19 pandemic had a radical impact on some family caregivers causing emotional despair. They feared not only infecting the patient with SARS-CoV-2 to cause an untimely death but also being unable to be there for the patient during hospitalization, especially in the patient's final days.", "doi": "10.1080/17482631.2022.2113021", "pmid": "35979626", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9397423"}], "notes": [], "created": "2022-09-12T18:41:52.197Z", "modified": "2022-09-12T18:42:07.522Z"}, {"entity": "publication", "iuid": "192bd823143141d99c5ce6074b66c9cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/192bd823143141d99c5ce6074b66c9cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/192bd823143141d99c5ce6074b66c9cf"}}, "title": "Continuation of fibrate therapy in patients with metabolic syndrome and COVID-19: a beneficial regime worth pursuing.", "authors": [{"family": "Vuorio", "given": "Alpo", "initials": "A", "orcid": "0000-0002-5504-2959", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ced6a984e09a43b2805f1bc49faedaa1.json"}}, {"family": "Brinck", "given": "Jonas", "initials": "J"}, {"family": "Kovanen", "given": "Petri T", "initials": "PT", "orcid": "0000-0002-2532-367X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84f610f43369437ba754d852866a83dd.json"}}], "type": "journal article", "published": "2022-12-00", "journal": {"title": "Ann Med", "issn": "1365-2060", "volume": "54", "issue": "1", "pages": "1952-1955", "issn-l": null}, "abstract": "Based on separate protective mechanisms related to lipid metabolism, viral cell entry and inflammation, fibrate treatment might be advantageous among patients who have been taking fibrates before SARS-CoV-2 infection and continue taking them during the infection. Based on published data on hospitalized COVID-19 patients, we recommend that the clinicians should ask their patients with metabolic syndrome who are already taking fibrates to continue fibrate treatment during the COVID-19 illness. This recommendation applies to both outpatients and hospitalized patients. However, results from the ongoing randomized controlled trials (RCTs) using fenofibrate treatment for the prevention or treatment of COVID-19 have yet to prove that fenofibrate is clinically significant for this indication.KEY MESSAGESThe role of fibrates as a repurpose to treat SARS-CoV-2 is under investigation in at least three ongoing RCTs.Obesity, diabetes, hypertension and dyslipidaemia, individually or clustered as a discrete phenotype, the metabolic syndrome, typically associate with a more severe course of COVID-19.Fibrate treatment seems to be most advantageous among patients who have been taken fibrates before SARS-CoV-2 infection and are continuing to take them during the infection.We recommend that the clinicians encourage their patients who are already taking fibrate to continue using the drug throughout the COVID-19 illness.", "doi": "10.1080/07853890.2022.2095667", "pmid": "35818956", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9278418"}], "notes": [], "created": "2022-08-17T10:37:58.554Z", "modified": "2022-08-17T10:37:58.676Z"}, {"entity": "publication", "iuid": "960c8cf80a514f20bcaaede734be70f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/960c8cf80a514f20bcaaede734be70f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/960c8cf80a514f20bcaaede734be70f4"}}, "title": "Considering medical students' perception, concerns and needs for e-exam during COVID-19: a promising approach to improve subject specific e-exams.", "authors": [{"family": "Ziehfreund", "given": "Stefanie", "initials": "S", "orcid": "0000-0003-3176-1120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce3b717d48094ef79f02636755ea893a.json"}}, {"family": "Reifenrath", "given": "Johannes", "initials": "J"}, {"family": "Wijnen-Meijer", "given": "Marjo", "initials": "M"}, {"family": "Welzel", "given": "Julia", "initials": "J"}, {"family": "Sauter", "given": "Fabian", "initials": "F"}, {"family": "Wecker", "given": "Hannah", "initials": "H"}, {"family": "Biedermann", "given": "Tilo", "initials": "T"}, {"family": "Zink", "given": "Alexander", "initials": "A"}], "type": "journal article", "published": "2022-12-00", "journal": {"title": "Med Educ Online", "issn": "1087-2981", "volume": "27", "issue": "1", "pages": "2114131", "issn-l": null}, "abstract": "The COVID-19 pandemic forced a rapid shift to digital strategies including e-exams in medical schools. However, there are significant concerns, predominately from student perspectives, and further data is required to successfully establish e-assessment in the medical curricula. The objective of the study was to examine medical students' perceptions, concerns, and needs regarding e-assessment to establish a comprehensive e-exam based on these and previous findings and to evaluate its effectiveness in terms of examinee perceptions and further needs. During the 2021 summer term, a cross-sectional study using qualitative and quantitative methods was conducted among all 1077 students at the School of Medicine, Technical University of Munich. They were asked to provide information regarding their characteristics, preferred exam format, e-assessment perception, concerns, and needs in an online questionnaire. Based on these findings, a pilot e-exam including an e-exam preparation for the students were established and subsequently evaluated among 125 pilot e-exam examinees under study consideration via an online-questionnaire. Of the 317 pre-exam participants (73.2% female), 70.3% preferred in-person exams and showed concerns about the technological framework, privacy, and examination requirements. Qualitative analysis showed that these concerns lead to additional exam stress and fear of failure. The 34 (79.4% female) participants who participated in the evaluation survey showed a significantly more positive e-exam perception. The fairness of the platform, the independence from an internet connection, the organization including the e-exam preparation, and the consideration of participant needs were discussed as particularly positive in the open-ended comments. In both surveys, participants requested uniform platforms and processes for all subjects. This study provides evidence for a positive, complementary role of student participation in a successful e-exam implementation. Furthermore, when establishing an e-exam format in the medical curricula, e-exam training, equal accessibility, availability offline, and all-round fairness should be considered.", "doi": "10.1080/10872981.2022.2114131", "pmid": "35993348", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9397442"}], "notes": [], "created": "2022-09-12T18:53:10.704Z", "modified": "2022-09-12T18:53:10.829Z"}, {"entity": "publication", "iuid": "b558292026a7442ba7979879012b5a38", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b558292026a7442ba7979879012b5a38.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b558292026a7442ba7979879012b5a38"}}, "title": "Bayesian nowcasting with leading indicators applied to COVID-19 fatalities in Sweden.", "authors": [{"family": "Bergstr\u00f6m", "given": "Fanny", "initials": "F", "orcid": "0000-0002-0693-3851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fb53e3138c64a00ae6f60214d4d23b6.json"}}, {"family": "G\u00fcnther", "given": "Felix", "initials": "F"}, {"family": "H\u00f6hle", "given": "Michael", "initials": "M", "orcid": "0000-0002-0423-6702", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4c004a5b6de46d7baabeffdef938778.json"}}, {"family": "Britton", "given": "Tom", "initials": "T"}], "type": "journal article", "published": "2022-12-00", "journal": {"title": "PLoS Comput Biol", "issn": "1553-7358", "volume": "18", "issue": "12", "pages": "e1010767", "issn-l": null}, "abstract": "The real-time analysis of infectious disease surveillance data is essential in obtaining situational awareness about the current dynamics of a major public health event such as the COVID-19 pandemic. This analysis of e.g., time-series of reported cases or fatalities is complicated by reporting delays that lead to under-reporting of the complete number of events for the most recent time points. This can lead to misconceptions by the interpreter, for instance the media or the public, as was the case with the time-series of reported fatalities during the COVID-19 pandemic in Sweden. Nowcasting methods provide real-time estimates of the complete number of events using the incomplete time-series of currently reported events and information about the reporting delays from the past. In this paper we propose a novel Bayesian nowcasting approach applied to COVID-19-related fatalities in Sweden. We incorporate additional information in the form of time-series of number of reported cases and ICU admissions as leading signals. We demonstrate with a retrospective evaluation that the inclusion of ICU admissions as a leading signal improved the nowcasting performance of case fatalities for COVID-19 in Sweden compared to existing methods.", "doi": "10.1371/journal.pcbi.1010767", "pmid": "36477048", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC9762573"}, {"db": "pii", "key": "PCOMPBIOL-D-22-01107"}], "notes": [], "created": "2023-01-13T13:33:58.495Z", "modified": "2023-01-13T13:33:58.562Z"}, {"entity": "publication", "iuid": "08ccf53710c34f02a790a5405cea03b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/08ccf53710c34f02a790a5405cea03b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/08ccf53710c34f02a790a5405cea03b9"}}, "title": "Mental health outcomes following COVID-19 infection: impacts of post-COVID impairments and fatigue on depression, anxiety, and insomnia - a web survey in Sweden.", "authors": [{"family": "Badinlou", "given": "Farzaneh", "initials": "F"}, {"family": "Lundgren", "given": "Tobias", "initials": "T"}, {"family": "Jansson-Fr\u00f6jmark", "given": "Markus", "initials": "M"}], "type": "journal article", "published": "2022-11-29", "journal": {"title": "BMC Psychiatry", "issn": "1471-244X", "volume": "22", "issue": "1", "pages": "743", "issn-l": null}, "abstract": "The negative impact of the COVID-19 pandemic on the mental health is now clearly established. However, information on the levels of mental ill health of people infected with COVID-19 and potential correlates of poor mental health is still limited. Therefore, the current study aimed to study indicative of potential mental health problems in individuals with a history of probable or confirmed SARS CoV-2 infection/infections and address the impacts of post-COVID impairments and fatigue following COVID-19 infection/infections on depression, anxiety, and insomnia.\n\nA web-survey including demographics, questions related to COVID-19 status and post-COVID impairments, and standardized measures of depression, anxiety, insomnia, and fatigue was completed by 507 individuals with a history of probable or confirmed SARS CoV-2 infection/infections.\n\nWe found significant rates of significant depression, anxiety, and insomnia in our sample, with more than 70% experiencing levels above the clinical cut offs for at least one psychological health problems. Higher levels of depression, anxiety, and insomnia were associated with the severity of COVID-19 infection in the acute phase, hospitalization because of COVID-19, and higher levels of post-COVID impairments and fatigue. Reduced motivation emerged as the strongest predictor for mental ill health.\n\nThese findings highlight that individuals infected with COVID-19, especially those who still have experienced post-COVID impairments, are more likely to suffer from mental ill-health and may be more vulnerable for poor mental health outcomes. Therefore, more effective actions are needed to take in order to promote and protect mental health of individuals with a history of COVID-19 infection.", "doi": "10.1186/s12888-022-04405-0", "pmid": "36447183", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9708120"}, {"db": "pii", "key": "10.1186/s12888-022-04405-0"}], "notes": [], "created": "2023-01-13T13:49:40.950Z", "modified": "2023-01-13T13:49:40.952Z"}, {"entity": "publication", "iuid": "f2224afaa64745eca88acf3366c2efdb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f2224afaa64745eca88acf3366c2efdb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f2224afaa64745eca88acf3366c2efdb"}}, "title": "Media use and trust during the COVID-19 pandemic: evidence from eight cross-sectional surveys in Sweden.", "authors": [{"family": "Winters", "given": "Maike", "initials": "M", "orcid": "0000-0003-0915-6506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35b530d67b244b999f697b2923b32bbf.json"}}, {"family": "Biermann", "given": "Olivia", "initials": "O"}, {"family": "Bohlin", "given": "Gustav", "initials": "G"}, {"family": "Bergman", "given": "Martin", "initials": "M"}, {"family": "Broun\u00e9us", "given": "Fredrik", "initials": "F"}, {"family": "Zeebari", "given": "Zangin", "initials": "Z"}, {"family": "Nordenstedt", "given": "Helena", "initials": "H"}], "type": "journal article", "published": "2022-11-29", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "volume": "32", "issue": "6", "pages": "976-981", "issn-l": "1101-1262"}, "abstract": "While a lot has been written about Sweden's COVID-19 control strategy, less is known about Swedish residents' media use during the pandemic and trust in and perceived agreement among key stakeholders commenting in the media.\n\nEight online, nationwide surveys were fielded between March and August 2020, during the first wave of the coronavirus pandemic in Sweden, with 8146 responses. Questions were asked on media usage, perceived tone of media, trust in key pandemic stakeholder groups commenting in the media (politicians, journalists, government officials, doctors/healthcare professionals and researchers) and perceived agreement among these key stakeholders about how the pandemic was handled in Sweden.\n\nUsing five or more information sources was associated with increased perceived alarmism in the media. Women and those with tertiary education were more likely to trust key pandemic actors. Trust in doctors/healthcare professionals and researchers remained high over the course of the study, trust in politicians and journalists was relatively low throughout the study period, with a slight increase in April 2020. Trust in key stakeholders was strongly associated with perceived agreement among the key stakeholders.\n\nOur results show that trust in stakeholders was strongly associated with perceived consistency of messages from those stakeholders. The inverse also holds: perceived conflicting messages among stakeholders was associated with low trust in them. Taken together, this could point to the importance of building trust before a crisis. Trust-building efforts could be targeted to men and those with lower educational attainment, as they had lower trust in key stakeholders.", "doi": "10.1093/eurpub/ckac145", "pmid": "36223605", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC9619753"}, {"db": "pii", "key": "6759691"}], "notes": [], "created": "2023-01-13T13:55:42.245Z", "modified": "2023-01-13T13:55:42.281Z"}, {"entity": "publication", "iuid": "bae809b1d1e2474b8e24f68b4c332315", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bae809b1d1e2474b8e24f68b4c332315.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bae809b1d1e2474b8e24f68b4c332315"}}, "title": "Mucosal IgA against SARS-CoV-2 Omicron Infection. Reply.", "authors": [{"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "letter", "published": "2022-11-24", "journal": {"title": "N Engl J Med", "issn": "1533-4406", "issn-l": null, "volume": "387", "issue": "21", "pages": "e55"}, "abstract": null, "doi": "10.1056/NEJMc2213153", "pmid": "36416779", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: H2020": null, "Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "10.1056/NEJMc2213153#sa2"}], "notes": [], "created": "2022-11-25T07:15:01.636Z", "modified": "2022-11-25T07:17:36.842Z"}, {"entity": "publication", "iuid": "70c6b11ead9f439c85df5c95971b36e6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70c6b11ead9f439c85df5c95971b36e6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70c6b11ead9f439c85df5c95971b36e6"}}, "title": "Effects of COVID-19 on the Human Central Olfactory System: A Natural Pre-Post Experiment", "authors": [{"family": "Thunell", "given": "E", "initials": "E", "orcid": "0000-0002-9368-4661", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5da807e735af4a5a8a933fae9b7facc4.json"}}, {"family": "Peter", "given": "M G", "initials": "MG", "orcid": "0000-0003-4472-795X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb77dd5d98864db79f47b9c59edb3530.json"}}, {"family": "Lenoir", "given": "V", "initials": "V", "orcid": "0000-0002-8140-8010", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a2fcaf4f76849ffb23f71e1289381df.json"}}, {"family": "Andersson", "given": "P", "initials": "P", "orcid": "0000-0001-9807-446X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87b95f3d1c8a4aecaa0a7ebfa9e6d0a6.json"}}, {"family": "Landis", "given": "B N", "initials": "BN", "orcid": "0000-0001-6034-3724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14b3e598649c40998778371286527b8c.json"}}, {"family": "Becker", "given": "M", "initials": "M", "orcid": "0000-0001-9644-9053", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00c51cc049aa40799398a72230f16c0d.json"}}, {"family": "Lundstr\u00f6m", "given": "J N", "initials": "JN", "orcid": "0000-0002-3529-8981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a92f50aea024a1fbf0cfda979efef11.json"}}], "type": "journal-article", "published": "2022-11-24", "journal": {"title": "AJNR Am J Neuroradiol", "issn": "0195-6108", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.3174/ajnr.a7713", "pmid": "36423956", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:42:39.664Z", "modified": "2022-11-25T07:11:04.729Z"}, {"entity": "publication", "iuid": "7ab0920969114ec5909c80f2bd372253", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7ab0920969114ec5909c80f2bd372253.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7ab0920969114ec5909c80f2bd372253"}}, "title": "Corrigendum: Vaccine safety surveillance using routinely collected healthcare data\u2014An empirical evaluation of epidemiological designs", "authors": [{"family": "Schuemie", "given": "Martijn J", "initials": "MJ"}, {"family": "Arshad", "given": "Faaizah", "initials": "F"}, {"family": "Pratt", "given": "Nicole", "initials": "N"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Lai", "given": "Lana Y H", "initials": "LYH"}, {"family": "Li", "given": "Xintong", "initials": "X"}, {"family": "Fortin", "given": "Stephen", "initials": "S"}, {"family": "Minty", "given": "Evan", "initials": "E"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}], "type": "journal-article", "published": "2022-11-24", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "issn-l": "1663-9812", "volume": "13", "issue": null, "pages": "1088973"}, "abstract": "[This corrects the article DOI: 10.3389/fphar.2022.893484.].", "doi": "10.3389/fphar.2022.1088973", "pmid": "36506524", "labels": {"Category: Health": null, "Type: Other": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC9731373"}, {"db": "pii", "key": "1088973"}], "notes": [], "created": "2023-01-13T10:01:41.744Z", "modified": "2023-12-08T06:17:45.933Z"}, {"entity": "publication", "iuid": "0e008e3a54a5489dbbdbe804147970ba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e008e3a54a5489dbbdbe804147970ba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e008e3a54a5489dbbdbe804147970ba"}}, "title": "Why women choose self-managed telemedicine abortion in the Netherlands during the COVID-19 pandemic: a national mixed methods study.", "authors": [{"family": "Cui", "given": "Nanke", "initials": "N", "orcid": "0000-0001-6780-7106", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b76f8edda00f4355bb31d820f7183366.json"}}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}, {"family": "Gomperts", "given": "Rebecca", "initials": "R"}], "type": "journal article", "published": "2022-11-21", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-2009", "issn-l": "2515-1991"}, "abstract": "The COVID-19 pandemic has imposed strict lockdown restrictions that have introduced barriers to in-person abortion clinic visits in the Netherlands. Women on Web (WoW) is a global medical abortion telemedicine service operating outside the formal health sector.\n\nTo understand the motivations and perceived barriers women faced when choosing telemedicine abortion outside the formal health sector, and how this was affected by the pandemic.\n\n178 women who completed an online consultation on the Dutch WoW website during the period 6 March 2020 to 5 March 2021 were included in this cross-sectional cohort study and exploratory qualitative study. Patient characteristics and motivations were analysed and associated with the severity of COVID-19 restrictions. Email exchanges in which women could further describe their requests were also examined for recurrent clarification of motivations.\n\nWomen experienced barriers to regular abortion care due to COVID-19 restrictions and had the preference to (1) self-manage their abortion, (2) stay in the comfort of their own home, and (3) keep their abortion private. In particular, women who did not live in the cities where abortion clinics were located experienced barriers to abortion services. As COVID-19 restrictions tightened, it was more frequently mentioned that women sought help from WoW because COVID-19 restrictions and abortion care were not accessible to them in the Netherlands. In the qualitative analysis of email exchanges, the reasons of COVID-19, privacy concerns, and domestic violence were particularly evident.\n\nIn the Netherlands, barriers to receiving adequate abortion care were exacerbated for women in vulnerable positions such as being geographically farther away from an abortion clinic, being in a deprived socioeconomic position, or being in an unsafe home situation. Similar to other medical care, abortion care should be deliverable online.", "doi": "10.1136/bmjsrh-2022-201591", "pmid": "36410763", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjsrh-2022-201591"}], "notes": [], "created": "2022-11-22T10:00:11.822Z", "modified": "2022-11-22T10:00:28.944Z"}, {"entity": "publication", "iuid": "7b8c22670a484cbdac5ca3ae2436fe17", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b8c22670a484cbdac5ca3ae2436fe17.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b8c22670a484cbdac5ca3ae2436fe17"}}, "title": "Human cytomegalovirus infection of epithelial cells increases SARS-CoV-2 superinfection by upregulating the ACE2 receptor.", "authors": [{"family": "Perera", "given": "Marianne R", "initials": "MR", "orcid": "0000-0001-9175-0568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/455783d64b804bb18b75d77628a63d82.json"}}, {"family": "Greenwood", "given": "Edward Jd", "initials": "EJ"}, {"family": "Crozier", "given": "Thomas Wm", "initials": "TW"}, {"family": "Elder", "given": "Elizabeth G", "initials": "EG"}, {"family": "Schmitt", "given": "Janika", "initials": "J"}, {"family": "Crump", "given": "Colin M", "initials": "CM"}, {"family": "Lehner", "given": "Paul J", "initials": "PJ"}, {"family": "Wills", "given": "Mark R", "initials": "MR"}, {"family": "Sinclair", "given": "John H", "initials": "JH"}], "type": "journal article", "published": "2022-11-21", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899"}, "abstract": "SARS-CoV-2, the causative agent of COVID-19, has caused widespread morbidity and mortality since its onset in late 2019. Here, we demonstrate that prior infection with human cytomegalovirus (HCMV) substantially increases infection with SARS-CoV-2 in vitro. HCMV is a common herpesvirus carried by 40-100% of the population which can reactivate in the lung under inflammatory conditions, such as those resulting from SARS-CoV-2 infection. We show in both endothelial and epithelial cell types that HCMV infection upregulates ACE2, the SARS-CoV-2 cell entry receptor. These observations suggest that HCMV reactivation events in the lung of healthy HCMV carriers could exacerbate SARS-CoV-2 infection and subsequent COVID-19 symptoms. This effect could contribute to the disparity of disease severity seen in ethnic minorities and those with lower socio-economic status, due to their higher CMV seroprevalence. Our results warrant further clinical investigation as to whether HCMV infection influences the pathogenesis of SARS-CoV-2.", "doi": "10.1093/infdis/jiac452", "pmid": "36408607", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6835053"}], "notes": [], "created": "2022-11-22T10:02:17.593Z", "modified": "2022-11-22T10:02:17.628Z"}, {"entity": "publication", "iuid": "84ce80a5ceb44e6ea8458c999fea427b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84ce80a5ceb44e6ea8458c999fea427b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84ce80a5ceb44e6ea8458c999fea427b"}}, "title": "Detection of SARS-CoV-2 antibodies in serum and dried blood spot samples of vaccinated individuals using a sensitive homogeneous proximity extension assay.", "authors": [{"family": "Zhao", "given": "Hongxing", "initials": "H"}, {"family": "Wang", "given": "Mengqi", "initials": "M"}, {"family": "Muthelo", "given": "Phathutshedzo", "initials": "P"}, {"family": "L\u00f6f", "given": "Liza", "initials": "L"}, {"family": "Sterky", "given": "Fredrik", "initials": "F"}, {"family": "Gallini", "given": "Radiosa", "initials": "R"}, {"family": "Kumar", "given": "Nallani Vijay", "initials": "NV"}, {"family": "Monsen", "given": "Tor", "initials": "T"}, {"family": "Nilsson", "given": "Kenneth", "initials": "K"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Kamali-Moghaddam", "given": "Masood", "initials": "M"}, {"family": "Mei", "given": "Ya-Fang", "initials": "YF"}, {"family": "Landegren", "given": "Ulf", "initials": "U"}], "type": "journal article", "published": "2022-11-21", "journal": {"title": "N Biotechnol", "issn": "1876-4347", "issn-l": null}, "abstract": "A homogeneous PCR-based assay for sensitive and specific detection of antibodies in serum or dried blood spots (DBS) is presented and the method is used to monitor individuals infected with or vaccinated against SARS-CoV-2. Detection probes were prepared by conjugating the recombinant spike protein subunit 1 (S1), containing the receptor binding domain (RBD) of SARS-CoV-2, to each of a pair of specific oligonucleotides. The same was done for the nucleocapsid protein (NP). Upon incubation with serum or DBS samples, the bi- or multivalency of the antibodies (IgG, IgA or IgM) brings pairs of viral proteins with their conjugated oligonucleotides in proximity and can be detected by a modified proximity extension assay (PEA). Anti-S1 and anti-NP antibodies could be detected simultaneously from one incubation reaction. This Antibody PEA (AbPEA) test uses only 1\u00b5l of neat or up to 100,000-fold diluted serum or one \u00f81.2mm disc cut from a DBS. All 100 investigated sera and 21 DBS collected prior to the COVID-19 outbreak were negative, demonstrating a 100% specificity. The area under the curve, as evaluated by the Receiver Operating Characteristic (ROC) analysis reached 0.998 (95%CI: 0.993-1) for samples taken from 11 days after symptoms onset. The kinetics of antibody responses were monitored after a first and second vaccination using serially collected DBS from 14 individuals. AbPEA offers highly specific and sensitive solution-phase antibody detection without requirement for secondary antibodies, no elution step when using DBS sample and a simple procedure that lends itself to multiplex survey of antibody responses.", "doi": "10.1016/j.nbt.2022.11.004", "pmid": "36423830", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1871-6784(22)00063-2"}], "notes": [], "created": "2022-11-25T07:12:23.583Z", "modified": "2022-11-25T07:12:47.576Z"}, {"entity": "publication", "iuid": "d576447f4dd14b6dae0e0cb5e7ea381e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d576447f4dd14b6dae0e0cb5e7ea381e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d576447f4dd14b6dae0e0cb5e7ea381e"}}, "title": "A comprehensive characterisation of patients diagnosed with post-COVID-19 condition in Sweden 16 months after the introduction of the ICD-10 diagnosis code (U09.9): a population-based cohort study.", "authors": [{"family": "Bygdell", "given": "Maria", "initials": "M"}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Lundberg", "given": "Lisa", "initials": "L"}, {"family": "Gyll", "given": "David", "initials": "D"}, {"family": "Martikainen", "given": "Jari", "initials": "J"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2022-11-18", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": null, "issue": null, "pages": null}, "abstract": "The objective of this study was to provide a comprehensive characterisation of patients diagnosed with post-COVID-19 condition (PCC) during the first 16 months of usage of the International Classification of Diseases revision 10 (ICD-10) diagnosis code U09.9 in Sweden.\n\nWe used data from national registers and primary healthcare databases for all adult inhabitants of the two largest regions in Sweden, comprising 4.1 million inhabitants (approximately 40% of the Swedish population). We present the cumulative incidence and incidence rate of PCC overall and among subgroups and describe COVID-19 patients with or without PCC regarding sociodemographic characteristics, comorbidities, subsequent diseases, COVID-19 severity, and virus variants.\n\nOf all registered COVID-19 cases available for PCC diagnosis (n=506,107), 2.0% (n=10,196) had been diagnosed with PCC using ICD-10 code U09.9 as of 15 February 2022 in the two largest regions in Sweden. The cumulative incidence was higher among women compared to men (2.3% vs 1.6%, p<0.001). The majority of PCC cases (n=7,162, 70.2%) had not been hospitalised for COVID-19. This group was more commonly female (69.9% vs 52.9%, p<0.001), had a tertiary education (51.0% vs 44.1%, p<0.001), and was older (median age difference 5.7 years, p<0.001) compared to non-hospitalised COVID-19 patients without PCC.\n\nThis characterisation furthers the understanding of patients diagnosed with PCC and could support policymakers with appropriate societal and healthcare resource allocation.", "doi": "10.1016/j.ijid.2022.11.021", "pmid": "36410693", "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Research Area: Call 1": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(22)00612-9"}], "notes": [], "created": "2022-11-22T10:01:50.032Z", "modified": "2022-11-25T07:21:32.562Z"}, {"entity": "publication", "iuid": "302309021a0f49308e65147d54053a8e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/302309021a0f49308e65147d54053a8e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/302309021a0f49308e65147d54053a8e"}}, "title": "Self-reported symptom severity, general health, and impairment in post-acute phases of COVID-19: retrospective cohort study of Swedish public employees.", "authors": [{"family": "Larsson", "given": "Simon B", "initials": "SB"}, {"family": "von Feilitzen", "given": "Gustaf Stuk\u00e1t", "initials": "GS"}, {"family": "Andersson", "given": "Maria E", "initials": "ME"}, {"family": "Sikora", "given": "Per", "initials": "P"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Nord\u00e9n", "given": "Rickard", "initials": "R"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Sigstr\u00f6m", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2022-11-17", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "19818", "issn-l": "2045-2322"}, "abstract": "This study aimed to examine current symptom severity and general health in a sample of primarily non-hospitalized persons with polymerase chain reaction (PCR) confirmed COVID-19 in comparison to PCR negative controls. During the first quarter of 2021, we conducted an online survey among public employees in West Sweden, with a valid COVID-19 test result. The survey assessed past-month severity of 28 symptoms and signs, self-rated health, the WHO Disability Assessment Schedule (WHODAS) 2.0 and illness severity at the time of test. We linked participants' responses to their SARS-CoV-2 PCR tests results. We compared COVID-19 positive and negative participants using univariable and multivariable regression analyses. Out of 56,221 invited, 14,222 (25.3%) responded, with a response rate of 50% among SARS-CoV-2 positive individuals. Analysis included 10,194 participants (86.4% women, mean age 45 years) who tested positive 4-12 weeks (N = 1425; subacute) and > 12 weeks (N = 1584; postcovid) prior to the survey, and 7185 PCR negative participants who did not believe that they had had COVID-19. Symptoms were highly prevalent in all groups, with worst symptoms in subacute phase participants, followed by postcovid phase and PCR negative participants. The most specific symptom for COVID-19 was loss of smell or taste. Both WHODAS 2.0 score and self-rated health were worst in subacute participants, and modestly worse in postcovid participants than in negative controls. Female gender, older age and acute illness severity had larger effects on self-rated health and WHODAS 2.0 score in PCR positive participants than in PCR negative. Studies with longer follow-up are needed to determine the long-term improvement after COVID-19.", "doi": "10.1038/s41598-022-24307-1", "pmid": "36396860", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9672032"}, {"db": "pii", "key": "10.1038/s41598-022-24307-1"}], "notes": [], "created": "2022-11-25T07:23:08.875Z", "modified": "2022-11-25T07:23:08.878Z"}, {"entity": "publication", "iuid": "bb8633cac6b742179bc3ea753f065938", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb8633cac6b742179bc3ea753f065938.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb8633cac6b742179bc3ea753f065938"}}, "title": "A population-based, retrospective cohort study of the association between ABO blood group and risk of COVID-19.", "authors": [{"family": "Dahl\u00e9n", "given": "Torsten", "initials": "T", "orcid": "0000-0002-3856-7227", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69a3a4703c134438836a76bd0dec1c68.json"}}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Edgren", "given": "Gustaf", "initials": "G", "orcid": "0000-0002-2198-4745", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8202fb97787474d931b94103878cf32.json"}}], "type": "journal article", "published": "2022-11-13", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null}, "abstract": "Several studies have investigated associations between ABO blood group and risk of COVID-19, with inconsistent results.\n\nTo study associations between ABO blood group and risk of different stages of COVID-19.\n\nThe study was based on nationwide registers encompassing all blood-grouped persons in Sweden, and all of their COVID-19 related outcomes. Associations between ABO blood group and COVID-19 outcomes were estimated using Poisson regression models. Analyses were conducted overall and stratified by vaccination status.\n\nA total of 4,986,878 individuals were included. The incidence rate ratios (IRRs), of testing positive for COVID-19 were 1.08 (95% confidence interval [CI], 1.07-1.08), 1.06 (95% CI, 1.05-1.07), and 1.01 (95% CI, 1.00-1.01) for blood groups A, AB, and B, as compared to O, respectively. Similar associations were seen for risk of hospital admissions, ICU admissions, and risk of death. For most outcomes, associations with ABO blood group were much attenuated or even reversed in vaccinated individuals.\n\nIndividuals with blood groups A, AB, and B are at increased risk of contracting COVID-19 as well as developing more severe forms of the disease. This article is protected by copyright. All rights reserved.", "doi": "10.1111/joim.13588", "pmid": "36372955", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-11-25T10:44:16.941Z", "modified": "2022-11-25T10:44:17.014Z"}, {"entity": "publication", "iuid": "48d95388505149eaa1f7304347c87a05", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/48d95388505149eaa1f7304347c87a05.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/48d95388505149eaa1f7304347c87a05"}}, "title": "Long-term SARS-CoV-2 surveillance in the wastewater of Stockholm: What lessons can be learned from the Swedish perspective?", "authors": [{"family": "Perez-Zabaleta", "given": "Mariel", "initials": "M"}, {"family": "Archer", "given": "Amena", "initials": "A"}, {"family": "Khatami", "given": "Kasra", "initials": "K"}, {"family": "Jafferali", "given": "Mohammed Hakim", "initials": "MH"}, {"family": "Nandy", "given": "Prachi", "initials": "P"}, {"family": "Atasoy", "given": "Merve", "initials": "M"}, {"family": "Birgersson", "given": "Madeleine", "initials": "M"}, {"family": "Williams", "given": "Cecilia", "initials": "C"}, {"family": "Cetecioglu", "given": "Zeynep", "initials": "Z"}], "type": "journal article", "published": "2022-11-08", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "volume": "858", "issue": "Pt 3", "pages": "160023", "issn-l": "0048-9697"}, "abstract": "Wastewater-based epidemiology (WBE) can be used to track the spread of SARS-CoV-2 in a population. This study presents the learning outcomes from over two-year long monitoring of SARS-CoV-2 in Stockholm, Sweden. The three main wastewater treatment plants in Stockholm, with a total of six inlets, were monitored from April 2020 until June 2022 (in total 600 samples). This spans five major SARS-CoV-2 waves, where WBE data provided early warning signals for each wave. Further, the measured SARS-CoV-2 content in the wastewater correlated significantly with the level of positive COVID-19 tests (r = 0.86; p << 0.0001) measured by widespread testing of the population. Moreover, as a proof-of-concept, six SARS-CoV-2 variants of concern were monitored using hpPCR assay, demonstrating that variants can be traced through wastewater monitoring. During this long-term surveillance, two sampling protocols, two RNA concentration/extraction methods, two calculation approaches, and normalization to the RNA virus Pepper mild mottle virus (PMMoV) were evaluated. In addition, a study of storage conditions was performed, demonstrating that the decay of viral RNA was significantly reduced upon the addition of glycerol to the wastewater before storage at -80 \u00b0C. Our results provide valuable information that can facilitate the incorporation of WBE as a prediction tool for possible future outbreaks of SARS-CoV-2 and preparations for future pandemics.", "doi": "10.1016/j.scitotenv.2022.160023", "pmid": "36356735", "labels": {"Category: Other": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Research Area: Environmental virus profiling": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9640212"}, {"db": "pii", "key": "S0048-9697(22)07123-6"}], "notes": [], "created": "2022-11-25T10:50:01.947Z", "modified": "2022-11-25T10:50:01.951Z"}, {"entity": "publication", "iuid": "acbce148a528462aab930c001ed75746", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/acbce148a528462aab930c001ed75746.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/acbce148a528462aab930c001ed75746"}}, "title": "Innate immune mechanisms of mRNA vaccines.", "authors": [{"family": "Verbeke", "given": "Rein", "initials": "R"}, {"family": "Hogan", "given": "Michael J", "initials": "MJ"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "Pardi", "given": "Norbert", "initials": "N"}], "type": "journal article", "published": "2022-11-08", "journal": {"title": "Immunity", "issn": "1074-7613", "volume": "55", "issue": "11", "pages": "1993-2005", "issn-l": null}, "abstract": "The lipid nanoparticle (LNP)-encapsulated, nucleoside-modified mRNA platform has been used to generate safe and effective vaccines in record time against COVID-19. Here, we review the current understanding of the manner whereby mRNA vaccines induce innate immune activation and how this contributes to protective immunity. We discuss innate immune sensing of mRNA vaccines at the cellular and intracellular levels and consider the contribution of both the mRNA and the LNP components to their immunogenicity. A key message that is emerging from recent observations is that the LNP carrier acts as a powerful adjuvant for this novel vaccine platform. In this context, we highlight important gaps in understanding and discuss how new insight into the mechanisms underlying the effectiveness of mRNA-LNP vaccines may enable tailoring mRNA and carrier molecules to develop vaccines with greater effectiveness and milder adverse events in the future.", "doi": "10.1016/j.immuni.2022.10.014", "pmid": "36351374", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC9641982"}, {"db": "pii", "key": "S1074-7613(22)00555-6"}], "notes": [], "created": "2022-11-25T10:51:09.699Z", "modified": "2022-11-25T10:51:09.708Z"}, {"entity": "publication", "iuid": "4bf9511a136b46edaede7c1cedfd44a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4bf9511a136b46edaede7c1cedfd44a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4bf9511a136b46edaede7c1cedfd44a4"}}, "title": "Size distribution of exhaled aerosol particles containing SARS-CoV-2 RNA.", "authors": [{"family": "Alsved", "given": "Malin", "initials": "M", "orcid": "0000-0002-8407-8758", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f599d60401c1483a9422fbb048c6d050.json"}}, {"family": "Nygren", "given": "David", "initials": "D", "orcid": "0000-0003-2426-7204", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d84ae6e240ec4a3caaf519a43f9d7cf9.json"}}, {"family": "Thuresson", "given": "Sara", "initials": "S", "orcid": "0000-0001-8243-3632", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21b29967898c42dd87cd587d662500d5.json"}}, {"family": "Fraenkel", "given": "Carl-Johan", "initials": "CJ", "orcid": "0000-0002-3086-5553", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6aec05367593436baef9decc3616e9c9.json"}}, {"family": "Medstrand", "given": "Patrik", "initials": "P", "orcid": "0000-0003-4259-8744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/558185ff31d94cacb1931015f2e12be4.json"}}, {"family": "L\u00f6ndahl", "given": "Jakob", "initials": "J", "orcid": "0000-0001-9379-592X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7648041474a8469aa54218ca177e4c19.json"}}], "type": "journal article", "published": "2022-11-04", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "pages": "1-6", "issn-l": "2374-4235"}, "abstract": "SARS-CoV-2 in exhaled aerosols is considered an important contributor to the spread of COVID-19. However, characterizing the size distribution of virus-containing aerosol particles has been challenging as high concentrations of SARS-CoV-2 in exhaled air is mainly present close to symptom onset. We present a case study of a person with COVID-19 who was able to participate in extensive measurements of exhaled aerosols already on the day of symptom onset and then for the following three days.\n\nAerosol collection was performed using an eight-stage impactor while the subject was breathing, talking and singing, for 30 min each, once every day. In addition, nasopharyngeal samples, saliva samples, room air samples and information on symptom manifestations were collected every day. Samples were analyzed by RT-qPCR for detection of SARS-CoV-2 RNA.\n\nSARS-CoV-2 RNA was detected in seven of the eight particle size fractions, from 0.34 to >8.1 \u00b5m, with the highest concentrations found in 0.94-2.8 \u00b5m particles. The concentration of SARS-CoV-2 RNA was highest on the day of symptom onset, and declined for each day thereafter.\n\nOur data showed that 90% of the exhaled SARS-CoV-2 RNA was found in aerosol particles <4.5 \u00b5m, indicating the importance of small particles for the transmission of COVID-19 close to symptom onset. These results are important for our understanding of airborne transmission, for developing accurate models and for selecting appropriate mitigation strategies.", "doi": "10.1080/23744235.2022.2140822", "pmid": "36331347", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Funder: Forte": null, "Type: Journal article": null, "Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-11-25T10:53:30.989Z", "modified": "2022-11-25T10:53:45.902Z"}, {"entity": "publication", "iuid": "9b06a05223c148d0b2e540a049dd360d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b06a05223c148d0b2e540a049dd360d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b06a05223c148d0b2e540a049dd360d"}}, "title": "An intersectional analysis of sociodemographic disparities in Covid-19 vaccination: A nationwide register-based study in Sweden.", "authors": [{"family": "Spetz", "given": "M", "initials": "M"}, {"family": "Lundberg", "given": "L", "initials": "L"}, {"family": "Nwaru", "given": "C", "initials": "C"}, {"family": "Li", "given": "H", "initials": "H"}, {"family": "Santosa", "given": "A", "initials": "A"}, {"family": "Ng", "given": "N", "initials": "N"}, {"family": "Leach", "given": "S", "initials": "S"}, {"family": "Gissl\u00e9n", "given": "M", "initials": "M"}, {"family": "Hammar", "given": "N", "initials": "N"}, {"family": "Nyberg", "given": "F", "initials": "F"}, {"family": "Rosvall", "given": "M", "initials": "M"}], "type": "journal article", "published": "2022-11-02", "journal": {"title": "Vaccine", "issn": "1873-2518", "volume": "40", "issue": "46", "pages": "6640-6648", "issn-l": null}, "abstract": "Studies on sociodemographic disparities in Covid-19 vaccination uptake in the general population are still limited and mostly focused on older adults. This study examined sociodemographic differences in Covid-19 vaccination uptake in the total Swedish population aged 18-64 years.\n\nNational Swedish register data within the SCIFI-PEARL project were used to cross-sectionally investigate sociodemographic differences in Covid-19 vaccination among Swedish adults aged 18-64 years (n = 5,987,189) by 12 October 2021. Using logistic regression models, analyses were adjusted for sociodemographic factors, region of residence, history of Covid-19, and comorbidities. An intersectional analysis approach including several cross-classified subgroups was used to further address the complexity of sociodemographic disparities in vaccination uptake.\n\nBy 12 October 2021, 76\u00b70% of the Swedish population 18-64 years old had received at least two doses of Covid-19 vaccine, an additional 5\u00b75% had received only one dose, and 18\u00b75% were non-vaccinated. Non-vaccinated individuals were, compared to vaccinated, more often younger, male, had a lower income, were not gainfully employed, and/or were born outside Sweden. The social patterning for vaccine dose two was similar, but weaker, than for dose one. After multivariable adjustments, findings remained but were attenuated indicating the need to consider different sociodemographic factors simultaneously. The intersectional analysis showed a large variation in vaccine uptake ranging from 32% to 96% in cross-classified subgroups, reflecting considerable sociodemographic heterogeneity in vaccination coverage.\n\nOur study, addressing the entire Swedish population aged 18-64 years, showed broad sociodemographic disparities in Covid-19 vaccine uptake but also wide heterogeneities in coverage. The intersectional analysis approach indicates that focusing on specific sociodemographic factors in isolation and group average risks without considering the heterogeneity within such groups will risk missing the full variability of vaccine coverage.\n\nSciLifeLab / Knut & Alice Wallenberg Foundation, Swedish Research Council, Swedish government ALF agreement, FORMAS.", "doi": "10.1016/j.vaccine.2022.09.065", "pmid": "36210254", "labels": {"Research Area: Vaccine": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Public Health": null, "Category: Health": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC9515344"}, {"db": "pii", "key": "S0264-410X(22)01186-0"}], "notes": [], "created": "2022-11-29T14:27:27.622Z", "modified": "2022-11-29T14:27:27.626Z"}, {"entity": "publication", "iuid": "c3ab49fa7c1c4adeae09264231eff500", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3ab49fa7c1c4adeae09264231eff500.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3ab49fa7c1c4adeae09264231eff500"}}, "title": "Updated Results of the COVID-19 in MS Global Data Sharing Initiative: Anti-CD20 and Other Risk Factors Associated With COVID-19 Severity.", "authors": [{"family": "Simpson-Yap", "given": "Steve", "initials": "S"}, {"family": "Pirmani", "given": "Ashkan", "initials": "A"}, {"family": "Kalincik", "given": "Tomas", "initials": "T"}, {"family": "De Brouwer", "given": "Edward", "initials": "E"}, {"family": "Geys", "given": "Lotte", "initials": "L"}, {"family": "Parciak", "given": "Tina", "initials": "T"}, {"family": "Helme", "given": "Anne", "initials": "A"}, {"family": "Rijke", "given": "Nick", "initials": "N"}, {"family": "Hillert", "given": "Jan A", "initials": "JA"}, {"family": "Moreau", "given": "Yves", "initials": "Y"}, {"family": "Edan", "given": "Gilles", "initials": "G"}, {"family": "Sharmin", "given": "Sifat", "initials": "S"}, {"family": "Spelman", "given": "Tim", "initials": "T"}, {"family": "McBurney", "given": "Robert", "initials": "R"}, {"family": "Schmidt", "given": "Hollie", "initials": "H"}, {"family": "Bergmann", "given": "Arnfin B", "initials": "AB"}, {"family": "Braune", "given": "Stefan", "initials": "S"}, {"family": "Stahmann", "given": "Alexander", "initials": "A"}, {"family": "Middleton", "given": "Rod M", "initials": "RM"}, {"family": "Salter", "given": "Amber", "initials": "A"}, {"family": "Bebo", "given": "Bruce", "initials": "B"}, {"family": "Van der Walt", "given": "Anneke", "initials": "A"}, {"family": "Butzkueven", "given": "Helmut", "initials": "H"}, {"family": "Ozakbas", "given": "Serkan", "initials": "S"}, {"family": "Boz", "given": "Cavit", "initials": "C"}, {"family": "Karabudak", "given": "Rana", "initials": "R"}, {"family": "Alroughani", "given": "Raed", "initials": "R"}, {"family": "Rojas", "given": "Juan I", "initials": "JI"}, {"family": "van der Mei", "given": "Ingrid A", "initials": "IA"}, {"family": "Sciascia do Olival", "given": "Guilherme", "initials": "G"}, {"family": "Magyari", "given": "Melinda", "initials": "M"}, {"family": "Alonso", "given": "Ricardo N", "initials": "RN"}, {"family": "Nicholas", "given": "Richard S", "initials": "RS"}, {"family": "Chertcoff", "given": "Anibal S", "initials": "AS"}, {"family": "de Torres", "given": "Ana Zabalza", "initials": "AZ"}, {"family": "Arrambide", "given": "Georgina", "initials": "G"}, {"family": "Nag", "given": "Nupur", "initials": "N"}, {"family": "Descamps", "given": "Annabel", "initials": "A"}, {"family": "Costers", "given": "Lars", "initials": "L"}, {"family": "Dobson", "given": "Ruth", "initials": "R"}, {"family": "Miller", "given": "Aleisha", "initials": "A"}, {"family": "Rodrigues", "given": "Paulo", "initials": "P"}, {"family": "Pr\u010dkovska", "given": "Vesna", "initials": "V"}, {"family": "Comi", "given": "Giancarlo", "initials": "G"}, {"family": "Peeters", "given": "Liesbet M", "initials": "LM"}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "Neurol Neuroimmunol Neuroinflamm", "issn": "2332-7812", "volume": "9", "issue": "6", "pages": "e200021", "issn-l": null}, "abstract": "Certain demographic and clinical characteristics, including the use of some disease-modifying therapies (DMTs), are associated with severe acute respiratory syndrome coronavirus 2 infection severity in people with multiple sclerosis (MS). Comprehensive exploration of these relationships in large international samples is needed.\n\nClinician-reported demographic/clinical data from 27 countries were aggregated into a data set of 5,648 patients with suspected/confirmed coronavirus disease 2019 (COVID-19). COVID-19 severity outcomes (hospitalization, admission to intensive care unit [ICU], requiring artificial ventilation, and death) were assessed using multilevel mixed-effects ordered probit and logistic regression, adjusted for age, sex, disability, and MS phenotype. DMTs were individually compared with glatiramer acetate, and anti-CD20 DMTs with pooled other DMTs and with natalizumab.\n\nOf 5,648 patients, 922 (16.6%) with suspected and 4,646 (83.4%) with confirmed COVID-19 were included. Male sex, older age, progressive MS, and higher disability were associated with more severe COVID-19. Compared with glatiramer acetate, ocrelizumab and rituximab were associated with higher probabilities of hospitalization (4% [95% CI 1-7] and 7% [95% CI 4-11]), ICU/artificial ventilation (2% [95% CI 0-4] and 4% [95% CI 2-6]), and death (1% [95% CI 0-2] and 2% [95% CI 1-4]) (predicted marginal effects). Untreated patients had 5% (95% CI 2-8), 3% (95% CI 1-5), and 1% (95% CI 0-3) higher probabilities of the 3 respective levels of COVID-19 severity than glatiramer acetate. Compared with pooled other DMTs and with natalizumab, the associations of ocrelizumab and rituximab with COVID-19 severity were also more pronounced. All associations persisted/enhanced on restriction to confirmed COVID-19.\n\nAnalyzing the largest international real-world data set of people with MS with suspected/confirmed COVID-19 confirms that the use of anti-CD20 medication (both ocrelizumab and rituximab), as well as male sex, older age, progressive MS, and higher disability are associated with more severe course of COVID-19.", "doi": "10.1212/NXI.0000000000200021", "pmid": "36038263", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9423711"}, {"db": "pii", "key": "9/6/e200021"}], "notes": [], "created": "2022-10-07T12:45:50.749Z", "modified": "2023-06-19T14:41:09.696Z"}, {"entity": "publication", "iuid": "863172b33d8c41d79b4bd9b33c12cb9a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/863172b33d8c41d79b4bd9b33c12cb9a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/863172b33d8c41d79b4bd9b33c12cb9a"}}, "title": "The association between pre-exposure to glucocorticoids and other immunosuppressant drugs with severe COVID-19 outcomes.", "authors": [{"family": "Brodin", "given": "Rakel", "initials": "R"}, {"family": "van der Werff", "given": "Suzannes Desir\u00e9e", "initials": "SD"}, {"family": "Hedberg", "given": "Pontus", "initials": "P"}, {"family": "F\u00e4rnert", "given": "Anna", "initials": "A"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Requena-M\u00e9ndez", "given": "Ana", "initials": "A"}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "Clin Microbiol Infect", "issn": "1469-0691", "volume": "28", "issue": "11", "pages": "1477-1485", "issn-l": null}, "abstract": "Whether preinfection use of immunosuppressant drugs is associated with COVID-19 severity remains unclear. The study was aimed to determine the association between preinfection use of immunosuppressant drugs with COVID-19 outcomes within 1 month after COVID-19 diagnosis.\n\nThis cohort study included individuals aged \u226518 years with underlying conditions associated with an immunocompromised state and diagnosed with COVID-19 between February 2020 and January 2021 at Karolinska University Hospital, Stockholm. Exposure to immunosuppressant drugs was defined based on dose and duration of drugs (glucocorticoids and drugs included in L01 or L04 chapter of Anatomical Therapeutic Chemical classification) before COVID-19 diagnosis. Outcomes included hospital admission, ICU admission, mechanical ventilation, mortality, renal failure, stroke, pulmonary embolism, and cardiac event. ORs were calculated using logistic regression and baseline covariate adjustment for confounding with inverse probability of treatment weights.\n\nOf 1067 included individuals, 444 were pre-exposed to immunosuppressive treatments before COVID-19 diagnosis (72 high-dose glucocorticoids, 255 L01 drugs (antineoplastics), 198 L04 (other immunosuppressants) and 78 to multiple drugs). There was no association between pre-exposure and hospital admission (OR 0.83, 95% CI 0.64 to 1.09) because of COVID-19. Pre-exposure to L01 or L04 drugs were not associated with hospital admission (adjusted ORs (aORs): 1.23, 0.86 to 1.76 and 1.31, 0.77 to 2.21) or other outcomes. High-dose glucocorticoids (\u226520 mg/day prednisolone equivalent) were associated with hospital admission (aOR 2.50, 1.26 to 4.96), cardiac events (aOR 1.93, 1.08 to 3.46), pulmonary embolism (aOR 2.78, 1.08 to 7.15), and mortality (aOR 3.48, 1.77 to 6.86) due to COVID-19.\n\nAntineoplastic and other immunosuppressants drugs were not associated with COVID-19 severity whereas high-dose glucocorticoids were associated. Further studies should evaluate the effect of pre-exposure of different dose of glucocorticoids on COVID-19 prognosis.", "doi": "10.1016/j.cmi.2022.05.014", "pmid": "35644344", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(22)00270-1"}, {"db": "pmc", "key": "PMC9135501"}], "notes": [], "created": "2022-06-21T17:35:23.959Z", "modified": "2022-10-31T17:26:54.979Z"}, {"entity": "publication", "iuid": "e2ff0bac268343ce8899e4948cf73082", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2ff0bac268343ce8899e4948cf73082.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2ff0bac268343ce8899e4948cf73082"}}, "title": "Patients' perspectives on the effect of the COVID-19 pandemic on access to cancer care and social contacts in Sweden and the UK: a cross-sectional study.", "authors": [{"family": "Edlund", "given": "Karolina", "initials": "K", "orcid": "0000-0003-2349-0076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8004580e2964f19aa44dca6399e4f84.json"}}, {"family": "Dahlstr\u00f6m", "given": "Lisen Arnheim", "initials": "LA", "orcid": "0000-0003-3926-9616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f5cf51d7b8e49cebe5e3743cb7ae71a.json"}}, {"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM", "orcid": "0000-0002-3912-1171", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f69d74b370764e2e93f8c98eca79e064.json"}}, {"family": "van der Kop", "given": "Mia L", "initials": "ML", "orcid": "0000-0002-5590-6833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b5c278a602240feb8953d0c02c029a0.json"}}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "Support Care Cancer", "issn": "1433-7339", "volume": "30", "issue": "11", "pages": "9101-9108", "issn-l": null}, "abstract": "We aimed to determine whether there was a difference in access to cancer-related healthcare between people living in Sweden and the United Kingdom (UK) during the COVID-19 pandemic. We also describe how the pandemic affected social contact of patients undergoing treatment.\n\nThis cross-sectional study used survey data collected through the War on Cancer mobile phone application between September 5, 2020, and January 6, 2021. We included individuals with cancer diagnoses living in Sweden or the UK. The association between difficulty accessing cancer-related healthcare and country was examined using logistic regression. Frequencies were used to describe the effect of the pandemic on social contact.\n\nOf 491 individuals included in the study, 183 were living in the UK and 308 in Sweden. Living in the UK was associated with greater difficulty accessing cancer-related healthcare (n = 99/183, 54.1%) than living in Sweden (n = 100/308, 32.5%) (odds ratio 2.12, 95% CI 1.39-3.23, p < 0.001). The pandemic affected social contact for almost all patients (n = 218/238, 91.6%) undergoing treatment.\n\nThis study highlights the differential impact that the pandemic may have had on patients' access to cancer-related care in the UK and Sweden. In both countries, the pandemic overwhelmingly affected social contact of individuals undergoing cancer treatment. New ways must be found to improve access to cancer-related care and reduce social isolation for patients with cancer during a pandemic.", "doi": "10.1007/s00520-022-07298-7", "pmid": "35984510", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9388965"}, {"db": "pii", "key": "10.1007/s00520-022-07298-7"}], "notes": [], "created": "2022-09-12T18:46:25.822Z", "modified": "2023-01-13T14:44:07.641Z"}, {"entity": "publication", "iuid": "59c5bb6eb35c4aabab0136466bd3af1e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/59c5bb6eb35c4aabab0136466bd3af1e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/59c5bb6eb35c4aabab0136466bd3af1e"}}, "title": "IL-6 signalling biomarkers in hospitalised patients with moderate to severe SARS-CoV-2 infection in a single centre study in Sweden.", "authors": [{"family": "Ziegler", "given": "Louise", "initials": "L"}, {"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Gigante", "given": "Bruna", "initials": "B"}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "Cytokine", "issn": "1043-4666", "issn-l": null, "volume": "159", "issue": null, "pages": "156020"}, "abstract": "COVID-19 disease severity and need for intensive care has been associated with profound immune disturbances in which interleukin 6 (IL-6) is central. IL-6 signals through two pathways: classical IL-6 signalling with C-reactive protein (CRP) as a product is pivotal in the acute immune response against pathogens while IL-6 trans-signalling is involved in prolonged inflammation. We measured biomarkers of the IL-6 classical and trans-signalling pathways in patients with moderate or severe COVID-19 in the first wave of the COVID-19 pandemic.\r\n\r\nIn a longitudinal cohort study including patients admitted to Danderyd hospital, Stockholm, Sweden, with COVID-19 (n = 112), plasma IL-6 mirroring activity in both pathways, CRP as marker of classical signalling and the soluble IL-6 receptor (sIL-6R) and soluble glycoprotein 130 (sgp130) as markers of trans-signalling were analysed at baseline. Potential differences in biomarker levels between groups of moderate and severe COVID-19 defined by care level, level of respiratory support and one-month mortality was analysed, as was correlations between biomarkers. In addition, levels 4 months after hospital admission were compared to those at baseline.\r\n\r\nLevels of IL-6 and CRP were increased in severe COVID-19 whereas IL-6 trans-signalling markers (sIL-6R, sgp130) did not differ between the groups. CRP correlated positively with IL-6 in all patients while correlation with IL-6 could not be demonstrated for sIL-6R and sgp130 in either group. Levels of IL-6, CRP and sIL-6R were significantly decreased after 4 months whereas sgp130 levels increased.\r\n\r\nClassical signalling is the dominating IL-6 pathway in moderate-severe COVID-19.", "doi": "10.1016/j.cyto.2022.156020", "pmid": "36057230", "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "S1043-4666(22)00229-0"}, {"db": "pmc", "key": "PMC9420722"}], "notes": [], "created": "2022-10-13T13:23:08.582Z", "modified": "2022-10-13T14:37:36.652Z"}, {"entity": "publication", "iuid": "c52dd95381fc49d9a6ea4aab11fd7674", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c52dd95381fc49d9a6ea4aab11fd7674.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c52dd95381fc49d9a6ea4aab11fd7674"}}, "title": "Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative.", "authors": [{"family": "Butler-Laporte", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-5388-0396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/529dc69151d3463e8480b975d70fa759.json"}}, {"family": "Povysil", "given": "Gundula", "initials": "G", "orcid": "0000-0003-4625-5909", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/658ac11ede214c9383221afb2d0b5ab1.json"}}, {"family": "Kosmicki", "given": "Jack A", "initials": "JA", "orcid": "0000-0003-1252-6192", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d39c52fe05574c1e90ca5f7e2daa921f.json"}}, {"family": "Cirulli", "given": "Elizabeth T", "initials": "ET", "orcid": "0000-0001-7808-2809", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/da51a8befd454b03b5bf8c50ca1835dd.json"}}, {"family": "Drivas", "given": "Theodore", "initials": "T", "orcid": "0000-0002-8717-0111", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c6643db2e4b4f92abf8a6b53c0d746a.json"}}, {"family": "Furini", "given": "Simone", "initials": "S"}, {"family": "Saad", "given": "Chadi", "initials": "C", "orcid": "0000-0001-6963-9126", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5636bfebba7144e7b729051d07f873ca.json"}}, {"family": "Schmidt", "given": "Axel", "initials": "A"}, {"family": "Olszewski", "given": "Pawel", "initials": "P", "orcid": "0000-0003-1010-8843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89b5f8798556430b867d8fcc5c2afbc6.json"}}, {"family": "Korotko", "given": "Urszula", "initials": "U", "orcid": "0000-0002-1779-8368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37a3dcefa2ca465cb9f3682f76ab5b83.json"}}, {"family": "Quinodoz", "given": "Mathieu", "initials": "M", "orcid": "0000-0002-9841-4433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41616c1f1c294ef585b140d8ee01434d.json"}}, {"family": "\u00c7elik", "given": "Elifnaz", "initials": "E", "orcid": "0000-0002-0324-5228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/043ad752eb754eb29107ebaff6a347c3.json"}}, {"family": "Kundu", "given": "Kousik", "initials": "K", "orcid": "0000-0002-1019-8351", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/775583a7e98545f1a4c5d1b2a94252b6.json"}}, {"family": "Walter", "given": "Klaudia", "initials": "K", "orcid": "0000-0003-4448-0301", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6e8e60bb41e40b399e86ee055bababd.json"}}, {"family": "Jung", "given": "Junghyun", "initials": "J"}, {"family": "Stockwell", "given": "Amy D", "initials": "AD"}, {"family": "Sloofman", "given": "Laura G", "initials": "LG", "orcid": "0000-0001-7628-4378", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/853b4f1cc0b04ed29fa07edb075688bc.json"}}, {"family": "Jordan", "given": "Daniel M", "initials": "DM", "orcid": "0000-0002-5318-8225", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/431bea0f7dbd46b0a60752f575783309.json"}}, {"family": "Thompson", "given": "Ryan C", "initials": "RC", "orcid": "0000-0002-0450-8181", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/acb45eb3b27e4b9191ddacfb0089321f.json"}}, {"family": "Del Valle", "given": "Diane", "initials": "D", "orcid": "0000-0001-6983-5362", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e9483a880d04872a10d52d4eb928e65.json"}}, {"family": "Simons", "given": "Nicole", "initials": "N", "orcid": "0000-0002-3952-1458", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a55f0ff0effc4d02b5ccb0a056b89936.json"}}, {"family": "Cheng", "given": "Esther", "initials": "E"}, {"family": "Sebra", "given": "Robert", "initials": "R"}, {"family": "Schadt", "given": "Eric E", "initials": "EE"}, {"family": "Kim-Schulze", "given": "Seunghee", "initials": "S"}, {"family": "Gnjatic", "given": "Sacha", "initials": "S"}, {"family": "Merad", "given": "Miriam", "initials": "M"}, {"family": "Buxbaum", "given": "Joseph D", "initials": "JD"}, {"family": "Beckmann", "given": "Noam D", "initials": "ND"}, {"family": "Charney", "given": "Alexander W", "initials": "AW"}, {"family": "Przychodzen", "given": "Bartlomiej", "initials": "B"}, {"family": "Chang", "given": "Timothy", "initials": "T", "orcid": "0000-0002-9225-9874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3bbf7182b1949eaaa49a64ca6b1946d.json"}}, {"family": "Pottinger", "given": "Tess D", "initials": "TD"}, {"family": "Shang", "given": "Ning", "initials": "N"}, {"family": "Brand", "given": "Fabian", "initials": "F", "orcid": "0000-0003-1885-7021", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3746b2b297d1475fbf6f40c0a0956bc6.json"}}, {"family": "Fava", "given": "Francesca", "initials": "F"}, {"family": "Mari", "given": "Francesca", "initials": "F"}, {"family": "Chwialkowska", "given": "Karolina", "initials": "K", "orcid": "0000-0001-8053-8959", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c03b0ca07f474484b9c6688e09ad9a1c.json"}}, {"family": "Niemira", "given": "Magdalena", "initials": "M", "orcid": "0000-0002-0701-4961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d67e7303fb3745a0bf8c606095670008.json"}}, {"family": "Pula", "given": "Szymon", "initials": "S", "orcid": "0000-0002-5684-5358", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5922e06d10574062ae4f2a8bea7ac407.json"}}, {"family": "Baillie", "given": "J Kenneth", "initials": "JK"}, {"family": "Stuckey", "given": "Alex", "initials": "A", "orcid": "0000-0001-8636-737X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f4f17b92dec479b8aa367a6e42cbb15.json"}}, {"family": "Salas", "given": "Antonio", "initials": "A"}, {"family": "Bello", "given": "Xabier", "initials": "X", "orcid": "0000-0002-4990-8496", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2dd3d12cbc884c8f811d94300bd67ebc.json"}}, {"family": "Pardo-Seco", "given": "Jacobo", "initials": "J"}, {"family": "G\u00f3mez-Carballa", "given": "Alberto", "initials": "A"}, {"family": "Rivero-Calle", "given": "Irene", "initials": "I"}, {"family": "Martin\u00f3n-Torres", "given": "Federico", "initials": "F"}, {"family": "Ganna", "given": "Andrea", "initials": "A"}, {"family": "Karczewski", "given": "Konrad J", "initials": "KJ", "orcid": "0000-0003-2878-4671", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/803dc14ee46c4c648056d01629e645c8.json"}}, {"family": "Veerapen", "given": "Kumar", "initials": "K"}, {"family": "Bourgey", "given": "Mathieu", "initials": "M", "orcid": "0000-0002-8432-834X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ed235e927a940d6a93a61be66137fec.json"}}, {"family": "Bourque", "given": "Guillaume", "initials": "G", "orcid": "0000-0002-3933-9656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7cf09c10c8d64159a13257ec588633c0.json"}}, {"family": "Eveleigh", "given": "Robert Jm", "initials": "RJ", "orcid": "0000-0002-4147-382X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3163112690e04d5abefa4f00b0d42948.json"}}, {"family": "Forgetta", "given": "Vincenzo", "initials": "V"}, {"family": "Morrison", "given": "David", "initials": "D", "orcid": "0000-0001-8380-3615", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6099e7b5999e486eb486bac1f455fdc1.json"}}, {"family": "Langlais", "given": "David", "initials": "D", "orcid": "0000-0003-4429-0110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6c1d5ffed164e62897e5df85e398629.json"}}, {"family": "Lathrop", "given": "Mark", "initials": "M"}, {"family": "Mooser", "given": "Vincent", "initials": "V", "orcid": "0000-0002-8632-0448", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7af40c95aeaf4dd7ab639b31f773b89a.json"}}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T", "orcid": "0000-0001-9510-5646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd273e50091d44c3b3e8d1473ce89b0a.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Marincevic-Zuniga", "given": "Yanara", "initials": "Y"}, {"family": "Nordlund", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8699-9959", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/63952dae96884221862363826c33746d.json"}}, {"family": "Schiabor Barrett", "given": "Kelly M", "initials": "KM", "orcid": "0000-0001-6194-787X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea0e8ac97dcf4591b579c2eae23ff5e9.json"}}, {"family": "Lee", "given": "William", "initials": "W"}, {"family": "Bolze", "given": "Alexandre", "initials": "A", "orcid": "0000-0001-7399-2766", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45c4e714f3054be69533f8d87f686485.json"}}, {"family": "White", "given": "Simon", "initials": "S", "orcid": "0000-0001-6375-2363", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d73512e150e04226b9862d24daa9c4fb.json"}}, {"family": "Riffle", "given": "Stephen", "initials": "S"}, {"family": "Tanudjaja", "given": "Francisco", "initials": "F"}, {"family": "Sandoval", "given": "Efren", "initials": "E"}, {"family": "Neveux", "given": "Iva", "initials": "I"}, {"family": "Dabe", "given": "Shaun", "initials": "S", "orcid": "0000-0002-2494-962X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d819354f7ed4d30b2d1df61905c9091.json"}}, {"family": "Casadei", "given": "Nicolas", "initials": "N", "orcid": "0000-0003-2209-0580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/413e813f99f8432e982e8849e446a716.json"}}, {"family": "Motameny", "given": "Susanne", "initials": "S", "orcid": "0000-0003-1186-1108", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db935de3e5b44cd99512cfb6342c8214.json"}}, {"family": "Alaamery", "given": "Manal", "initials": "M"}, {"family": "Massadeh", "given": "Salam", "initials": "S", "orcid": "0000-0001-9193-0008", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3214967d998b47c0bc9662c4b1157b2b.json"}}, {"family": "Aljawini", "given": "Nora", "initials": "N"}, {"family": "Almutairi", "given": "Mansour S", "initials": "MS", "orcid": "0000-0003-2736-8991", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51120e073f95436399117a8a0f568de1.json"}}, {"family": "Arabi", "given": "Yaseen M", "initials": "YM", "orcid": "0000-0001-5735-6241", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52d3898b4fb44f53b7d80475874d4894.json"}}, {"family": "Alqahtani", "given": "Saleh A", "initials": "SA"}, {"family": "Al Harthi", "given": "Fawz S", "initials": "FS"}, {"family": "Almutairi", "given": "Amal", "initials": "A"}, {"family": "Alqubaishi", "given": "Fatima", "initials": "F"}, {"family": "Alotaibi", "given": "Sarah", "initials": "S"}, {"family": "Binowayn", "given": "Albandari", "initials": "A"}, {"family": "Alsolm", "given": "Ebtehal A", "initials": "EA"}, {"family": "El Bardisy", "given": "Hadeel", "initials": "H"}, {"family": "Fawzy", "given": "Mohammad", "initials": "M", "orcid": "0000-0002-1318-9979", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6fe7222738b54cb09fce2d5128dcb393.json"}}, {"family": "Cai", "given": "Fang", "initials": "F"}, {"family": "Soranzo", "given": "Nicole", "initials": "N"}, {"family": "Butterworth", "given": "Adam", "initials": "A"}, {"family": "COVID-19 Host Genetics Initiative", "given": "", "initials": ""}, {"family": "DeCOI Host Genetics Group", "given": "", "initials": ""}, {"family": "GEN-COVID Multicenter Study (Italy)", "given": "", "initials": ""}, {"family": "Mount Sinai Clinical Intelligence Center", "given": "", "initials": ""}, {"family": "GEN-COVID consortium (Spain)", "given": "", "initials": ""}, {"family": "GenOMICC Consortium", "given": "", "initials": ""}, {"family": "Japan COVID-19 Task Force", "given": "", "initials": ""}, {"family": "Regeneron Genetics Center", "given": "", "initials": ""}, {"family": "Geschwind", "given": "Daniel H", "initials": "DH"}, {"family": "Arteaga", "given": "Stephanie", "initials": "S", "orcid": "0000-0003-1441-8849", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/652a5da6ce8e4c9bbfdbfe8f11768938.json"}}, {"family": "Stephens", "given": "Alexis", "initials": "A", "orcid": "0000-0002-5979-6838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/249f5a87985a463ab89b8f6f1022d829.json"}}, {"family": "Butte", "given": "Manish J", "initials": "MJ"}, {"family": "Boutros", "given": "Paul C", "initials": "PC"}, {"family": "Yamaguchi", "given": "Takafumi N", "initials": "TN", "orcid": "0000-0003-1082-3871", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac413398e38e48e4bb9f5b94cbf99a11.json"}}, {"family": "Tao", "given": "Shu", "initials": "S"}, {"family": "Eng", "given": "Stefan", "initials": "S", "orcid": "0000-0002-5245-6507", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d618fa1da8142b3bc9a30a86b0b4d1a.json"}}, {"family": "Sanders", "given": "Timothy", "initials": "T"}, {"family": "Tung", "given": "Paul J", "initials": "PJ"}, {"family": "Broudy", "given": "Michael E", "initials": "ME"}, {"family": "Pan", "given": "Yu", "initials": "Y"}, {"family": "Gonzalez", "given": "Alfredo", "initials": "A", "orcid": "0000-0001-8963-3135", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/331f872ae2894743b97ff14504d0324f.json"}}, {"family": "Chavan", "given": "Nikhil", "initials": "N"}, {"family": "Johnson", "given": "Ruth", "initials": "R", "orcid": "0000-0002-1929-0998", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77d872b3614a484dbabd0a66cf12c73a.json"}}, {"family": "Pasaniuc", "given": "Bogdan", "initials": "B"}, {"family": "Yaspan", "given": "Brian", "initials": "B", "orcid": "0000-0002-3787-2510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aaf6d84f442e4b09be17a2b0639db758.json"}}, {"family": "Smieszek", "given": "Sandra", "initials": "S", "orcid": "0000-0002-8006-0454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df8cabc7e6c543d880de72e68357e1b4.json"}}, {"family": "Rivolta", "given": "Carlo", "initials": "C", "orcid": "0000-0002-0733-9950", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91f3a7aa91a64175880dcc3c2e615c11.json"}}, {"family": "Bibert", "given": "Stephanie", "initials": "S"}, {"family": "Bochud", "given": "Pierre-Yves", "initials": "PY", "orcid": "0000-0002-2208-4757", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae5a5781ed614965b039e94739bf7a6a.json"}}, {"family": "Dabrowski", "given": "Maciej", "initials": "M", "orcid": "0000-0003-4150-3985", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a678606a0aa340559fe7916f806af31b.json"}}, {"family": "Zawadzki", "given": "Pawel", "initials": "P", "orcid": "0000-0002-9032-2315", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7695a8653b4e4b878878179e87bc9cc3.json"}}, {"family": "Sypniewski", "given": "Mateusz", "initials": "M"}, {"family": "Kaja", "given": "El\u017cbieta", "initials": "E", "orcid": "0000-0003-1277-6140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb9f22b55cae4da1834f8c3bfb741b59.json"}}, {"family": "Chariyavilaskul", "given": "Pajaree", "initials": "P", "orcid": "0000-0003-1096-6020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/beb2b4f73a5a410891031c2afe2fd6a4.json"}}, {"family": "Nilaratanakul", "given": "Voraphoj", "initials": "V", "orcid": "0000-0002-3964-5477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2ac1d215e144f699c8e5787a90df3cd.json"}}, {"family": "Hirankarn", "given": "Nattiya", "initials": "N", "orcid": "0000-0003-2224-6856", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9073cb795dd4839aa2cda851ba84000.json"}}, {"family": "Shotelersuk", "given": "Vorasuk", "initials": "V", "orcid": "0000-0002-1856-0589", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56f21402edbc4312aa672bf78f0dae0d.json"}}, {"family": "Pongpanich", "given": "Monnat", "initials": "M", "orcid": "0000-0003-3228-3351", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9051b469fa614e62a7b10d4e6ea2db86.json"}}, {"family": "Phokaew", "given": "Chureerat", "initials": "C", "orcid": "0000-0002-4246-2604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2be4f5c04e004ed9a6c61f2d47b0a101.json"}}, {"family": "Chetruengchai", "given": "Wanna", "initials": "W", "orcid": "0000-0003-2495-6595", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78faacad098041d4a386cce12d17c840.json"}}, {"family": "Tokunaga", "given": "Katsushi", "initials": "K"}, {"family": "Sugiyama", "given": "Masaya", "initials": "M", "orcid": "0000-0002-9084-7197", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/834495fe76c64a05a17f430dce9ad007.json"}}, {"family": "Kawai", "given": "Yosuke", "initials": "Y", "orcid": "0000-0003-0666-1224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33862e88b2774937a071237159822561.json"}}, {"family": "Hasegawa", "given": "Takanori", "initials": "T", "orcid": "0000-0001-7251-9950", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/342adeed9885409dbedc94c991dccd3e.json"}}, {"family": "Naito", "given": "Tatsuhiko", "initials": "T"}, {"family": "Namkoong", "given": "Ho", "initials": "H", "orcid": "0000-0001-6181-4284", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cf9a27fc9a6409990b1c5871bdddc90.json"}}, {"family": "Edahiro", "given": "Ryuya", "initials": "R"}, {"family": "Kimura", "given": "Akinori", "initials": "A"}, {"family": "Ogawa", "given": "Seishi", "initials": "S"}, {"family": "Kanai", "given": "Takanori", "initials": "T"}, {"family": "Fukunaga", "given": "Koichi", "initials": "K"}, {"family": "Okada", "given": "Yukinori", "initials": "Y"}, {"family": "Imoto", "given": "Seiya", "initials": "S"}, {"family": "Miyano", "given": "Satoru", "initials": "S", "orcid": "0000-0002-1753-6616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec9d5bbdbac34335906afc0dede1a0df.json"}}, {"family": "Mangul", "given": "Serghei", "initials": "S", "orcid": "0000-0003-4770-3443", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dbe15e382e84d38a0fd859377e39d47.json"}}, {"family": "Abedalthagafi", "given": "Malak S", "initials": "MS"}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ee1510080704cf6a2a6972deb94123f.json"}}, {"family": "Grzymski", "given": "Joseph J", "initials": "JJ", "orcid": "0000-0003-2646-8958", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/212250cafa7b4966914ad7455303c2be.json"}}, {"family": "Washington", "given": "Nicole L", "initials": "NL"}, {"family": "Ossowski", "given": "Stephan", "initials": "S", "orcid": "0000-0002-7416-9568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37310c6c082042b8a743635afd381644.json"}}, {"family": "Ludwig", "given": "Kerstin U", "initials": "KU", "orcid": "0000-0002-8541-2519", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02922a1f71c64a8e9dc6aa1c29a20270.json"}}, {"family": "Schulte", "given": "Eva C", "initials": "EC", "orcid": "0000-0003-3105-5672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b02ec0962cdc4e15853c4a3aeba4992d.json"}}, {"family": "Riess", "given": "Olaf", "initials": "O"}, {"family": "Moniuszko", "given": "Marcin", "initials": "M"}, {"family": "Kwasniewski", "given": "Miroslaw", "initials": "M"}, {"family": "Mbarek", "given": "Hamdi", "initials": "H"}, {"family": "Ismail", "given": "Said I", "initials": "SI"}, {"family": "Verma", "given": "Anurag", "initials": "A", "orcid": "0000-0002-5063-9107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ce606e23fdc4de8865ebb196fde5601.json"}}, {"family": "Goldstein", "given": "David B", "initials": "DB", "orcid": "0000-0001-7627-0259", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5954b96aeb15472bb7bc014760f1ba0b.json"}}, {"family": "Kiryluk", "given": "Krzysztof", "initials": "K", "orcid": "0000-0002-5047-6715", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d1362394dec4a7e934fd6c79ad94df3.json"}}, {"family": "Renieri", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-0846-9220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6388ba45f89d4c3b94c4c6c88f97cadb.json"}}, {"family": "Ferreira", "given": "Manuel A R", "initials": "MAR"}, {"family": "Richards", "given": "J Brent", "initials": "JB", "orcid": "0000-0002-3746-9086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8994152547ee4765b1653b834c52a21a.json"}}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "PLoS Genet", "issn": "1553-7404", "volume": "18", "issue": "11", "pages": "e1010367", "issn-l": null}, "abstract": "Host genetics is a key determinant of COVID-19 outcomes. Previously, the COVID-19 Host Genetics Initiative genome-wide association study used common variants to identify multiple loci associated with COVID-19 outcomes. However, variants with the largest impact on COVID-19 outcomes are expected to be rare in the population. Hence, studying rare variants may provide additional insights into disease susceptibility and pathogenesis, thereby informing therapeutics development. Here, we combined whole-exome and whole-genome sequencing from 21 cohorts across 12 countries and performed rare variant exome-wide burden analyses for COVID-19 outcomes. In an analysis of 5,085 severe disease cases and 571,737 controls, we observed that carrying a rare deleterious variant in the SARS-CoV-2 sensor toll-like receptor TLR7 (on chromosome X) was associated with a 5.3-fold increase in severe disease (95% CI: 2.75-10.05, p = 5.41x10-7). This association was consistent across sexes. These results further support TLR7 as a genetic determinant of severe disease and suggest that larger studies on rare variants influencing COVID-19 outcomes could provide additional insights.", "doi": "10.1371/journal.pgen.1010367", "pmid": "36327219", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9632827"}, {"db": "pii", "key": "PGENETICS-D-22-00434"}, {"db": "URL", "key": "https://github.com/DrGBL/WES.WGS", "description": "https://github.com/DrGBL/WES.WGS"}], "notes": [], "created": "2022-11-29T16:14:29.516Z", "modified": "2022-11-29T16:15:32.496Z"}, {"entity": "publication", "iuid": "6d229c4662244bc9a1951205596cb20c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6d229c4662244bc9a1951205596cb20c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6d229c4662244bc9a1951205596cb20c"}}, "title": "COVID-19 Information in Sweden: Opinions of Immigrants with Limited Proficiency in Swedish.", "authors": [{"family": "Roble", "given": "Sagal", "initials": "S"}, {"family": "W\u00e5ngdahl", "given": "Josefin", "initials": "J"}, {"family": "Warner", "given": "Georgina", "initials": "G", "orcid": "0000-0002-7850-9136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a44058151a6c4ff4be148921ad1e9e57.json"}}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "Health Commun", "issn": "1532-7027", "volume": "37", "issue": "12", "pages": "1510-1519", "issn-l": null}, "abstract": "COVID-19 has highlighted the importance of health information for prevention of communicable disease. Knowledge about groups that have high risk is important to prevent disease transmission. In Sweden, immigrants have been identified as one such group. Yet, little is known about where they have sourced information about COVID-19 and their opinions toward it. The aim of this study was to describe the COVID-19 information sources used by immigrants with limited proficiency in Swedish as well as their opinions on how comprehensive the information has been, the importance of the recommendations and their possibility to follow them. A cross-sectional survey was conducted via introductory Swedish language classes in Region Uppsala (n = 855). The results showed the immigrants were using different information sources, with the majority using school, media and social media. The immigrants' opinions about COVID-19 information differed. Most reported they knew where to find information; however, over two-fifths reported the recommendations from the authorities should be more extensive. The majority reported it is important to follow the recommendations, whereas the possibility to follow the recommendations was more mixed. Age differences in opinions toward COVID-19 information were detected. Although the results were largely positive, there still appears to be a need for improvement in how immigrant groups with limited ability in the host country\u00b4s language are reached. Effective health communication that engages the whole nation is an important factor authorities should commit to as we face the current pandemic. This research suggests that an approach tailored by age could be helpful.", "doi": "10.1080/10410236.2022.2050005", "pmid": "35287507", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-01-13T13:25:27.113Z", "modified": "2023-01-13T13:25:27.159Z"}, {"entity": "publication", "iuid": "3ae9d08a217348928d2628f0596b0ff2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ae9d08a217348928d2628f0596b0ff2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ae9d08a217348928d2628f0596b0ff2"}}, "title": "B-cell repopulation dynamics and drug pharmacokinetics impact SARS-CoV-2 vaccine efficacy in anti-CD20-treated multiple sclerosis patients.", "authors": [{"family": "Asplund H\u00f6gelin", "given": "Klara", "initials": "K", "orcid": "0000-0002-3696-355X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e30a564a8ac14f97af8d46d222dff3ab.json"}}, {"family": "Ruffin", "given": "Nicolas", "initials": "N"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Starvaggi Cucuzza", "given": "Chiara", "initials": "C"}, {"family": "Khademi", "given": "Mohsen", "initials": "M"}, {"family": "Olsson", "given": "Tomas", "initials": "T"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Al Nimer", "given": "Faiez", "initials": "F"}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "Eur J Neurol", "issn": "1468-1331", "issn-l": null, "volume": "29", "issue": "11", "pages": "3317-3328"}, "abstract": "Recent findings document a blunted humoral response to SARS-CoV-2 vaccination in patients on anti-CD20 treatment. Although most patients develop a cellular response, it is still important to identify predictors of seroconversion to optimize vaccine responses.\n\nWe determined antibody responses after SARS-CoV-2 vaccination in a real-world cohort of multiple sclerosis patients (n = 94) treated with anti-CD20, mainly rituximab, with variable treatment duration (median = 2.9, range = 0.4-9.6 years) and time from last anti-CD20 infusion to vaccination (median = 190, range = 60-1032 days).\n\nWe find that presence of B cells and/or rituximab in blood predict seroconversion better than time since last infusion. Using multiple logistic regression, presence of >0.5% B cells increased probability of seroconversion with an odds ratio (OR) of 5.0 (95% confidence interval [CI] = 1.0-28.1, p = 0.055), whereas the corresponding OR for \u22656 months since last infusion was 1.45 (95% CI = 0.20-10.15, p = 0.705). In contrast, detectable rituximab levels were negatively associated with seroconversion (OR = 0.05, 95% CI = 0.002-0.392, p = 0.012). Furthermore, na\u00efve and memory IgG+ B cells correlated with antibody levels. Although retreatment with rituximab at 4 weeks or more after booster depleted spike-specific B cells, it did not noticeably affect the rate of decline in antibody titers. Interferon-\u03b3 and/or interleukin-13 T-cell responses to the spike S1 domain were observed in most patients, but with no correlation to spike antibody levels.\n\nThese findings are relevant for providing individualized guidance to patients and planning of vaccination schemes, in turn optimizing benefit-risk with anti-CD20.", "doi": "10.1111/ene.15492", "pmid": "35808856", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Vaccines": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Vaccine": null}, "xrefs": [{"db": "pmc", "key": "PMC9349816"}], "notes": [], "created": "2022-08-15T14:47:44.894Z", "modified": "2022-10-17T14:51:58.545Z"}, {"entity": "publication", "iuid": "66b4f38551804f02a4d51ce775bafc3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66b4f38551804f02a4d51ce775bafc3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66b4f38551804f02a4d51ce775bafc3d"}}, "title": "Differential Bias for Creatinine- and Cystatin C- Derived Estimated Glomerular Filtration Rate in Critical COVID-19.", "authors": [{"family": "Larsson", "given": "Anders O", "initials": "AO", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2be858ab604743b72383dfdcd14689.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Nyman", "given": "Ulf", "initials": "U"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Eriksson", "given": "Mats B", "initials": "MB", "orcid": "0000-0002-3178-4210", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c90375295094966a51f9d17c275abb6.json"}}], "type": "journal article", "published": "2022-10-26", "journal": {"title": "Biomedicines", "issn": "2227-9059", "volume": "10", "issue": "11", "issn-l": null}, "abstract": "COVID-19 is a systemic disease, frequently affecting kidney function. Dexamethasone is standard treatment in severe COVID-19 cases, and is considered to increase plasma levels of cystatin C. However, this has not been studied in COVID-19. Glomerular filtration rate (GFR) is a clinically important indicator of renal function, but often estimated using equations (eGFR) based on filtered metabolites. This study focuses on sources of bias for eGFRs (mL/min) using a creatinine-based equation (eGFRLMR) and a cystatin C-based equation (eGFRCAPA) in intensive-care-treated patients with COVID-19. This study was performed on 351 patients aged 18 years old or above with severe COVID-19 infections, admitted to the intensive care unit (ICU) in Uppsala University Hospital, a tertiary care hospital in Uppsala, Sweden, between 14 March 2020 and 10 March 2021. Dexamethasone treatment (6 mg for up to 10 days) was introduced 22 June 2020 (n = 232). Values are presented as medians (IQR). eGFRCAPA in dexamethasone-treated patients was 69 (37), and 74 (46) in patients not given dexamethasone (p = 0.01). eGFRLMR was not affected by dexamethasone. eGFRLMR in females was 94 (20), and 75 (38) in males (p = 0.00001). Age and maximal CRP correlated negatively to eGFRCAPA and eGFRLMR, whereas both eGFR equations correlated positively to BMI. In ICU patients with COVID-19, dexamethasone treatment was associated with reduced eGFRCAPA. This finding may be explained by corticosteroid-induced increases in plasma cystatin C. This observation is important from a clinical perspective since adequate interpretation of laboratory results is crucial.", "doi": "10.3390/biomedicines10112708", "pmid": "36359231", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "biomedicines10112708"}], "notes": [], "created": "2022-11-25T10:46:17.171Z", "modified": "2022-11-25T10:46:17.220Z"}, {"entity": "publication", "iuid": "fbe760843fc148f79d4d40761ba99f43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fbe760843fc148f79d4d40761ba99f43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fbe760843fc148f79d4d40761ba99f43"}}, "title": "Do Comorbidities and Daily Medication before SARS-CoV-2 Infection Play a Role in Self-Reported Post-Infection Symptoms?", "authors": [{"family": "Va\u017eg\u0117lien\u0117", "given": "Dovil\u0117", "initials": "D"}, {"family": "Kubilius", "given": "Raimondas", "initials": "R"}, {"family": "Bileviciute-Ljungar", "given": "Indre", "initials": "I"}], "type": "journal article", "published": "2022-10-25", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "11", "issue": "21", "issn-l": "2077-0383"}, "abstract": "This study investigated the associations between health status before SARS-CoV-2 infection and persistent symptoms after acute infection. Data were collected from participants older than 18 years and more than 28 days after acute SARS-CoV-2 infection using an online survey. Sociodemographic data, comorbidities, and daily medication before infection, as well as acute and persistent symptoms were analysed. Among the 1050 participants (mean age 41 years, 88% women, 56% with higher education, 93% working), 538 (51%) reported being healthy and 762 (73%) reported not taking any daily medication prior to infection. Positive laboratory testing was reported by 965 (92%) participants; asymptomatic infection was reported by 30 (3%); and 999 (95%) stayed at home during their acute infection. Reduced physical capacity (40%), fatigue (39%), cognitive difficulties (30-34%), altered sense of smell (24%), headache (20%), tachycardia (20%), unstable mood (19%), hair loss (17%), and insomnia (17%) were the most often reported symptoms. Those taking daily medication before infection reported increased frequency of both acute and persistent symptoms, except for decreased frequency of persistent altered smell and taste. The presence of persistent symptoms was predicted by taking daily medication before infection and by the total number of acute symptoms. Comorbidities before infection did not predict persistent symptoms. Therefore, the role of medication needs further investigation in both acute SARS-CoV-2 infection and post-COVID-19 condition.", "doi": "10.3390/jcm11216278", "pmid": "36362506", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9657459"}, {"db": "pii", "key": "jcm11216278"}], "notes": [], "created": "2022-11-25T10:45:26.774Z", "modified": "2022-11-25T10:45:39.432Z"}, {"entity": "publication", "iuid": "7d7cf123a0dc4d75bd5aa3ca0a0759dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d7cf123a0dc4d75bd5aa3ca0a0759dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d7cf123a0dc4d75bd5aa3ca0a0759dd"}}, "title": "A Multiparametric and High-Throughput Platform for Host-Virus Binding Screens", "authors": [{"family": "Schlegel", "given": "Jan", "initials": "J"}, {"family": "Porebski", "given": "Bartlomiej", "initials": "B"}, {"family": "Andronico", "given": "Luca", "initials": "L"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Edwards", "given": "Steven", "initials": "S"}, {"family": "Brismar", "given": "Hjalmar", "initials": "H"}, {"family": "Murrell", "given": "Benjamin", "initials": "B"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Fernandez-Capetillo", "given": "Oscar", "initials": "O"}, {"family": "Sezgin", "given": "Erdinc", "initials": "E", "orcid": "0000-0002-4915-388X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30c3688527ac4caf8d07426703ace615.json"}}], "type": "posted-content", "published": "2022-10-11", "journal": {"title": "Medrxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.10.10.511545", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-12-01T13:38:49.854Z", "modified": "2023-01-27T13:01:57.807Z"}, {"entity": "publication", "iuid": "2a24a52cd8c84a8eb843e15301deda1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2a24a52cd8c84a8eb843e15301deda1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2a24a52cd8c84a8eb843e15301deda1d"}}, "title": "Estimated Global Proportions of Individuals With Persistent Fatigue, Cognitive, and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021.", "authors": [{"family": "Global Burden of Disease Long COVID Collaborators", "given": "", "initials": ""}, {"family": "Wulf Hanson", "given": "Sarah", "initials": "S"}, {"family": "Abbafati", "given": "Cristiana", "initials": "C"}, {"family": "Aerts", "given": "Joachim G", "initials": "JG"}, {"family": "Al-Aly", "given": "Ziyad", "initials": "Z"}, {"family": "Ashbaugh", "given": "Charlie", "initials": "C"}, {"family": "Ballouz", "given": "Tala", "initials": "T"}, {"family": "Blyuss", "given": "Oleg", "initials": "O"}, {"family": "Bobkova", "given": "Polina", "initials": "P"}, {"family": "Bonsel", "given": "Gouke", "initials": "G"}, {"family": "Borzakova", "given": "Svetlana", "initials": "S"}, {"family": "Buonsenso", "given": "Danilo", "initials": "D"}, {"family": "Butnaru", "given": "Denis", "initials": "D"}, {"family": "Carter", "given": "Austin", "initials": "A"}, {"family": "Chu", "given": "Helen", "initials": "H"}, {"family": "De Rose", "given": "Cristina", "initials": "C"}, {"family": "Diab", "given": "Mohamed Mustafa", "initials": "MM"}, {"family": "Ekbom", "given": "Emil", "initials": "E"}, {"family": "El Tantawi", "given": "Maha", "initials": "M"}, {"family": "Fomin", "given": "Victor", "initials": "V"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Gamirova", "given": "Aysylu", "initials": "A"}, {"family": "Glybochko", "given": "Petr V", "initials": "PV"}, {"family": "Haagsma", "given": "Juanita A", "initials": "JA"}, {"family": "Haghjooy Javanmard", "given": "Shaghayegh", "initials": "S"}, {"family": "Hamilton", "given": "Erin B", "initials": "EB"}, {"family": "Harris", "given": "Gabrielle", "initials": "G"}, {"family": "Heijenbrok-Kal", "given": "Majanka H", "initials": "MH"}, {"family": "Helbok", "given": "Raimund", "initials": "R"}, {"family": "Hellemons", "given": "Merel E", "initials": "ME"}, {"family": "Hillus", "given": "David", "initials": "D"}, {"family": "Huijts", "given": "Susanne M", "initials": "SM"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Jassat", "given": "Waasila", "initials": "W"}, {"family": "Kurth", "given": "Florian", "initials": "F"}, {"family": "Larsson", "given": "Ing-Marie", "initials": "IM"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Liu", "given": "Chelsea", "initials": "C"}, {"family": "Loflin", "given": "Callan D", "initials": "CD"}, {"family": "Malinovschi", "given": "Andrei", "initials": "A"}, {"family": "Mao", "given": "Wenhui", "initials": "W"}, {"family": "Mazankova", "given": "Lyudmila", "initials": "L"}, {"family": "McCulloch", "given": "Denise", "initials": "D"}, {"family": "Menges", "given": "Dominik", "initials": "D"}, {"family": "Mohammadifard", "given": "Noushin", "initials": "N"}, {"family": "Munblit", "given": "Daniel", "initials": "D"}, {"family": "Nekliudov", "given": "Nikita A", "initials": "NA"}, {"family": "Ogbuoji", "given": "Osondu", "initials": "O"}, {"family": "Osmanov", "given": "Ismail M", "initials": "IM"}, {"family": "Pe\u00f1alvo", "given": "Jos\u00e9 L", "initials": "JL"}, {"family": "Petersen", "given": "Maria Skaalum", "initials": "MS"}, {"family": "Puhan", "given": "Milo A", "initials": "MA"}, {"family": "Rahman", "given": "Mujibur", "initials": "M"}, {"family": "Rass", "given": "Verena", "initials": "V"}, {"family": "Reinig", "given": "Nickolas", "initials": "N"}, {"family": "Ribbers", "given": "Gerard M", "initials": "GM"}, {"family": "Ricchiuto", "given": "Antonia", "initials": "A"}, {"family": "Rubertsson", "given": "Sten", "initials": "S"}, {"family": "Samitova", "given": "Elmira", "initials": "E"}, {"family": "Sarrafzadegan", "given": "Nizal", "initials": "N"}, {"family": "Shikhaleva", "given": "Anastasia", "initials": "A"}, {"family": "Simpson", "given": "Kyle E", "initials": "KE"}, {"family": "Sinatti", "given": "Dario", "initials": "D"}, {"family": "Soriano", "given": "Joan B", "initials": "JB"}, {"family": "Spiridonova", "given": "Ekaterina", "initials": "E"}, {"family": "Steinbeis", "given": "Fridolin", "initials": "F"}, {"family": "Svistunov", "given": "Andrey A", "initials": "AA"}, {"family": "Valentini", "given": "Piero", "initials": "P"}, {"family": "van de Water", "given": "Brittney J", "initials": "BJ"}, {"family": "van den Berg-Emons", "given": "Rita", "initials": "R"}, {"family": "Wallin", "given": "Ewa", "initials": "E"}, {"family": "Witzenrath", "given": "Martin", "initials": "M"}, {"family": "Wu", "given": "Yifan", "initials": "Y"}, {"family": "Xu", "given": "Hanzhang", "initials": "H"}, {"family": "Zoller", "given": "Thomas", "initials": "T"}, {"family": "Adolph", "given": "Christopher", "initials": "C"}, {"family": "Albright", "given": "James", "initials": "J"}, {"family": "Amlag", "given": "Joanne O", "initials": "JO"}, {"family": "Aravkin", "given": "Aleksandr Y", "initials": "AY"}, {"family": "Bang-Jensen", "given": "Bree L", "initials": "BL"}, {"family": "Bisignano", "given": "Catherine", "initials": "C"}, {"family": "Castellano", "given": "Rachel", "initials": "R"}, {"family": "Castro", "given": "Emma", "initials": "E"}, {"family": "Chakrabarti", "given": "Suman", "initials": "S"}, {"family": "Collins", "given": "James K", "initials": "JK"}, {"family": "Dai", "given": "Xiaochen", "initials": "X"}, {"family": "Daoud", "given": "Farah", "initials": "F"}, {"family": "Dapper", "given": "Carolyn", "initials": "C"}, {"family": "Deen", "given": "Amanda", "initials": "A"}, {"family": "Duncan", "given": "Bruce B", "initials": "BB"}, {"family": "Erickson", "given": "Megan", "initials": "M"}, {"family": "Ewald", "given": "Samuel B", "initials": "SB"}, {"family": "Ferrari", "given": "Alize J", "initials": "AJ"}, {"family": "Flaxman", "given": "Abraham D", "initials": "AD"}, {"family": "Fullman", "given": "Nancy", "initials": "N"}, {"family": "Gamkrelidze", "given": "Amiran", "initials": "A"}, {"family": "Giles", "given": "John R", "initials": "JR"}, {"family": "Guo", "given": "Gaorui", "initials": "G"}, {"family": "Hay", "given": "Simon I", "initials": "SI"}, {"family": "He", "given": "Jiawei", "initials": "J"}, {"family": "Helak", "given": "Monika", "initials": "M"}, {"family": "Hulland", "given": "Erin N", "initials": "EN"}, {"family": "Kereselidze", "given": "Maia", "initials": "M"}, {"family": "Krohn", "given": "Kris J", "initials": "KJ"}, {"family": "Lazzar-Atwood", "given": "Alice", "initials": "A"}, {"family": "Lindstrom", "given": "Akiaja", "initials": "A"}, {"family": "Lozano", "given": "Rafael", "initials": "R"}, {"family": "Malta", "given": "Deborah Carvalho", "initials": "DC"}, {"family": "M\u00e5nsson", "given": "Johan", "initials": "J"}, {"family": "Mantilla Herrera", "given": "Ana M", "initials": "AM"}, {"family": "Mokdad", "given": "Ali H", "initials": "AH"}, {"family": "Monasta", "given": "Lorenzo", "initials": "L"}, {"family": "Nomura", "given": "Shuhei", "initials": "S"}, {"family": "Pasovic", "given": "Maja", "initials": "M"}, {"family": "Pigott", "given": "David M", "initials": "DM"}, {"family": "Reiner", "given": "Robert C", "initials": "RC"}, {"family": "Reinke", "given": "Grace", "initials": "G"}, {"family": "Ribeiro", "given": "Antonio Luiz P", "initials": "ALP"}, {"family": "Santomauro", "given": "Damian Francesco", "initials": "DF"}, {"family": "Sholokhov", "given": "Aleksei", "initials": "A"}, {"family": "Spurlock", "given": "Emma Elizabeth", "initials": "EE"}, {"family": "Walcott", "given": "Rebecca", "initials": "R"}, {"family": "Walker", "given": "Ally", "initials": "A"}, {"family": "Wiysonge", "given": "Charles Shey", "initials": "CS"}, {"family": "Zheng", "given": "Peng", "initials": "P"}, {"family": "Bettger", "given": "Janet Prvu", "initials": "JP"}, {"family": "Murray", "given": "Christopher J L", "initials": "CJL"}, {"family": "Vos", "given": "Theo", "initials": "T"}], "type": "journal article", "published": "2022-10-10", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484"}, "abstract": "Some individuals experience persistent symptoms after initial symptomatic SARS-CoV-2 infection (often referred to as Long COVID).\n\nTo estimate the proportion of males and females with COVID-19, younger or older than 20 years of age, who had Long COVID symptoms in 2020 and 2021 and their Long COVID symptom duration.\n\nBayesian meta-regression and pooling of 54 studies and 2 medical record databases with data for 1.2 million individuals (from 22 countries) who had symptomatic SARS-CoV-2 infection. Of the 54 studies, 44 were published and 10 were collaborating cohorts (conducted in Austria, the Faroe Islands, Germany, Iran, Italy, the Netherlands, Russia, Sweden, Switzerland, and the US). The participant data were derived from the 44 published studies (10 501 hospitalized individuals and 42 891 nonhospitalized individuals), the 10 collaborating cohort studies (10 526 and 1906), and the 2 US electronic medical record databases (250 928 and 846 046). Data collection spanned March 2020 to January 2022.\n\nSymptomatic SARS-CoV-2 infection.\n\nProportion of individuals with at least 1 of the 3 self-reported Long COVID symptom clusters (persistent fatigue with bodily pain or mood swings; cognitive problems; or ongoing respiratory problems) 3 months after SARS-CoV-2 infection in 2020 and 2021, estimated separately for hospitalized and nonhospitalized individuals aged 20 years or older by sex and for both sexes of nonhospitalized individuals younger than 20 years of age.\n\nA total of 1.2 million individuals who had symptomatic SARS-CoV-2 infection were included (mean age, 4-66 years; males, 26%-88%). In the modeled estimates, 6.2% (95% uncertainty interval [UI], 2.4%-13.3%) of individuals who had symptomatic SARS-CoV-2 infection experienced at least 1 of the 3 Long COVID symptom clusters in 2020 and 2021, including 3.2% (95% UI, 0.6%-10.0%) for persistent fatigue with bodily pain or mood swings, 3.7% (95% UI, 0.9%-9.6%) for ongoing respiratory problems, and 2.2% (95% UI, 0.3%-7.6%) for cognitive problems after adjusting for health status before COVID-19, comprising an estimated 51.0% (95% UI, 16.9%-92.4%), 60.4% (95% UI, 18.9%-89.1%), and 35.4% (95% UI, 9.4%-75.1%), respectively, of Long COVID cases. The Long COVID symptom clusters were more common in women aged 20 years or older (10.6% [95% UI, 4.3%-22.2%]) 3 months after symptomatic SARS-CoV-2 infection than in men aged 20 years or older (5.4% [95% UI, 2.2%-11.7%]). Both sexes younger than 20 years of age were estimated to be affected in 2.8% (95% UI, 0.9%-7.0%) of symptomatic SARS-CoV-2 infections. The estimated mean Long COVID symptom cluster duration was 9.0 months (95% UI, 7.0-12.0 months) among hospitalized individuals and 4.0 months (95% UI, 3.6-4.6 months) among nonhospitalized individuals. Among individuals with Long COVID symptoms 3 months after symptomatic SARS-CoV-2 infection, an estimated 15.1% (95% UI, 10.3%-21.1%) continued to experience symptoms at 12 months.\n\nThis study presents modeled estimates of the proportion of individuals with at least 1 of 3 self-reported Long COVID symptom clusters (persistent fatigue with bodily pain or mood swings; cognitive problems; or ongoing respiratory problems) 3 months after symptomatic SARS-CoV-2 infection.", "doi": "10.1001/jama.2022.18931", "pmid": "36215063", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "2797443"}], "notes": [], "created": "2022-10-17T14:46:34.295Z", "modified": "2022-10-17T14:47:20.543Z"}, {"entity": "publication", "iuid": "74a421fbdf7a4c958ee21843c31befa5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/74a421fbdf7a4c958ee21843c31befa5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/74a421fbdf7a4c958ee21843c31befa5"}}, "title": "Anti-Spike Mucosal IgA Protection against SARS-CoV-2 Omicron Infection.", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f28f2f6ac9648629c2d2de92fe7bb59.json"}}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Svensson", "given": "Julia", "initials": "J"}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Bacchus", "given": "Philip", "initials": "P", "orcid": "0000-0001-9800-1957", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77e288f7a3b94f6181c7c515273081b0.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "letter", "published": "2022-10-06", "journal": {"title": "N Engl J Med", "issn": "1533-4406", "volume": "387", "issue": "14", "pages": "1333-1336", "issn-l": null}, "abstract": null, "doi": "10.1056/NEJMc2209651", "pmid": "36103621", "labels": {"Category: Omicron VoC": null, "Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9511632"}], "notes": [], "created": "2022-10-13T12:55:59.528Z", "modified": "2023-06-19T14:27:04.997Z"}, {"entity": "publication", "iuid": "92c8bd61f38f45bd9d0efd0d0ebde090", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/92c8bd61f38f45bd9d0efd0d0ebde090.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/92c8bd61f38f45bd9d0efd0d0ebde090"}}, "title": "A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses.", "authors": [{"family": "Lenart", "given": "Klara", "initials": "K"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Ols", "given": "Sebastian", "initials": "S"}, {"family": "Yan", "given": "Xianglei", "initials": "X"}, {"family": "Cagigi", "given": "Alberto", "initials": "A"}, {"family": "Cerveira", "given": "Rodrigo Arcoverde", "initials": "RA"}, {"family": "Winge", "given": "Inga", "initials": "I"}, {"family": "Hanczak", "given": "Jakub", "initials": "J"}, {"family": "Mueller", "given": "Stefan O", "initials": "SO"}, {"family": "Jasny", "given": "Edith", "initials": "E"}, {"family": "Schwendt", "given": "Kim", "initials": "K"}, {"family": "Rauch", "given": "Susanne", "initials": "S"}, {"family": "Petsch", "given": "Benjamin", "initials": "B"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2022-10-06", "journal": {"title": "Mol Ther Methods Clin Dev", "issn": "2329-0501", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "A third vaccine dose is often required to achieve potent, long-lasting immune responses. We investigated the impact of three 8 \u03bcg doses of CVnCoV, CureVac's SARS-CoV-2 vaccine candidate containing sequence-optimized unmodified mRNA encoding spike (S) glycoprotein, administered at 0, 4 and 28 weeks on immune responses in rhesus macaques. Following the third dose S-specific binding and neutralizing antibodies increased 50-fold compared with post-dose 2 levels, with increased responses also evident in the lower airways and against the SARS-CoV-2 B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma) and B.1.617.2 (Delta) variants. Enhanced binding affinity of serum antibodies after the third dose correlated with higher somatic hypermutation in S-specific B cells, corresponding with improved binding properties of monoclonal antibodies expressed from isolated B cells. Administration of low dose mRNA led to fewer cells expressing antigen in vivo at the injection site and in the draining lymph nodes compared with a tenfold higher dose, possibly reducing the engagement of precursor cells with the antigen and resulting in the suboptimal response observed following two-dose vaccination schedules in phase IIb/III clinical trials of CVnCoV. However, when immune memory is established, a third dose efficiently boosts the immunological responses as well as improves antibody affinity and breadth.", "doi": "10.1016/j.omtm.2022.10.001", "pmid": "36217434", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Category: Vaccines": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Research Area: Vaccine": null}, "xrefs": [{"db": "pii", "key": "S2329-0501(22)00143-7"}, {"db": "pmc", "key": "PMC9535876"}], "notes": [], "created": "2022-10-13T15:23:38.735Z", "modified": "2022-10-17T14:57:33.385Z"}, {"entity": "publication", "iuid": "74f12da206e64e47a7de84c81a08e340", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/74f12da206e64e47a7de84c81a08e340.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/74f12da206e64e47a7de84c81a08e340"}}, "title": "A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA Viruses.", "authors": [{"family": "Lindqvist", "given": "Richard", "initials": "R"}, {"family": "Benz", "given": "Caroline", "initials": "C", "orcid": "0000-0002-5166-3598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13332514bfe7460db4a0f134718aa211.json"}}, {"family": "Sereikaite", "given": "Vita", "initials": "V"}, {"family": "Maassen", "given": "Lars", "initials": "L"}, {"family": "Laursen", "given": "Louise", "initials": "L"}, {"family": "Jemth", "given": "Per", "initials": "P", "orcid": "0000-0003-1516-7228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c5fe566cf5f44df9c98bb2b1d7078ba.json"}}, {"family": "Str\u00f8mgaard", "given": "Kristian", "initials": "K"}, {"family": "Ivarsson", "given": "Ylva", "initials": "Y"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK", "orcid": "0000-0001-6553-0940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9024ab251cf44bffbf3229ec909343af.json"}}], "type": "journal article", "published": "2022-10-06", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "10", "pages": "2202", "issn-l": "1999-4915"}, "abstract": "Viruses are dependent on host factors in order to efficiently establish an infection and replicate. Targeting the interactions of such host factors provides an attractive strategy to develop novel antivirals. Syntenin is a protein known to regulate the architecture of cellular membranes by its involvement in protein trafficking and has previously been shown to be important for human papilloma virus (HPV) infection. Here, we show that a highly potent and metabolically stable peptide inhibitor that binds to the PDZ1 domain of syntenin inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by blocking the endosomal entry of the virus. Furthermore, we found that the inhibitor also hampered chikungunya infection and strongly reduced flavivirus infection, which is completely dependent on receptor-mediated endocytosis for their entry. In conclusion, we have identified a novel broad spectrum antiviral inhibitor that efficiently targets a broad range of RNA viruses.", "doi": "10.3390/v14102202", "pmid": "36298757", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC9610207"}, {"db": "pii", "key": "v14102202"}], "notes": [], "created": "2022-10-31T17:26:05.478Z", "modified": "2023-06-19T15:04:01.062Z"}, {"entity": "publication", "iuid": "f47961871afa4d0dbb206f09276a3324", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f47961871afa4d0dbb206f09276a3324.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f47961871afa4d0dbb206f09276a3324"}}, "title": "A regression discontinuity analysis of the social distancing recommendations for older adults in Sweden during COVID-19.", "authors": [{"family": "Bonander", "given": "Carl", "initials": "C", "orcid": "0000-0002-1189-9950", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/386ac82b1a4843828b503ec807c08206.json"}}, {"family": "Stranges", "given": "Debora", "initials": "D", "orcid": "0000-0002-1782-8563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26d57656ec964be89179420faace6222.json"}}, {"family": "Gustavsson", "given": "Johanna", "initials": "J"}, {"family": "Almgren", "given": "Matilda", "initials": "M", "orcid": "0000-0003-1555-8069", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/faba1c6d698d4dffbca95ff4ee838626.json"}}, {"family": "Inghammar", "given": "Malin", "initials": "M"}, {"family": "Moghaddassi", "given": "Mahnaz", "initials": "M", "orcid": "0000-0002-0844-4736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a219bde5ba8a4f3f8655ada08d749885.json"}}, {"family": "Nilsson", "given": "Anton", "initials": "A", "orcid": "0000-0001-5774-7189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/915c1fe25c1d43c3ba55c5793d5e59be.json"}}, {"family": "Capdevila Pujol", "given": "Joan", "initials": "J"}, {"family": "Steves", "given": "Claire", "initials": "C"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Gomez", "given": "Maria F", "initials": "MF"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J", "orcid": "0000-0003-1883-2000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e88fdca336ae41c891f0a46e2481b67f.json"}}, {"family": "COVID Symptom Study Sweden", "given": "", "initials": ""}], "type": "journal article", "published": "2022-10-03", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": "32", "issue": "5", "pages": "799-806"}, "abstract": "This article investigates the impact of a non-mandatory and age-specific social distancing recommendation on isolation behaviours and disease outcomes in Sweden during the first wave of the coronavirus disease 2019 (COVID-19) pandemic (March to July 2020). The policy stated that people aged 70 years or older should avoid crowded places and contact with people outside the household.\n\nWe used a regression discontinuity design-in combination with self-reported isolation data from COVID Symptom Study Sweden (n = 96 053; age range: 39-79 years) and national register data (age range: 39-100+ years) on severe COVID-19 disease (hospitalization or death, n = 21 804) and confirmed cases (n = 48 984)-to estimate the effects of the policy.\n\nOur primary analyses showed a sharp drop in the weekly number of visits to crowded places (-13%) and severe COVID-19 cases (-16%) at the 70-year threshold. These results imply that the age-specific recommendations prevented approximately 1800-2700 severe COVID-19 cases, depending on model specification.\n\nIt seems that the non-mandatory, age-specific recommendations helped control COVID-19 disease during the first wave of the pandemic in Sweden, as opposed to not implementing a social distancing policy aimed at older adults. Our study provides empirical data on how populations may react to non-mandatory, age-specific social distancing policies in the face of a novel virus.", "doi": "10.1093/eurpub/ckac101", "pmid": "35962987", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9384721"}, {"db": "pii", "key": "6665904"}], "notes": [], "created": "2022-08-15T15:25:45.226Z", "modified": "2023-06-19T07:42:36.510Z"}, {"entity": "publication", "iuid": "a7a6bb5249734d7f8974f2cde50ef35a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7a6bb5249734d7f8974f2cde50ef35a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7a6bb5249734d7f8974f2cde50ef35a"}}, "title": "Probing effects of the SARS-CoV-2 E protein on membrane curvature and intracellular calcium.", "authors": [{"family": "Mehregan", "given": "Aujan", "initials": "A"}, {"family": "P\u00e9rez-Conesa", "given": "Sergio", "initials": "S"}, {"family": "Zhuang", "given": "Yuxuan", "initials": "Y"}, {"family": "Elbahnsi", "given": "Ahmad", "initials": "A"}, {"family": "Pasini", "given": "Diletta", "initials": "D"}, {"family": "Lindahl", "given": "Erik", "initials": "E"}, {"family": "Howard", "given": "Rebecca J", "initials": "RJ"}, {"family": "Ulens", "given": "Chris", "initials": "C"}, {"family": "Delemotte", "given": "Lucie", "initials": "L", "orcid": "0000-0002-0828-3899", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c75eddd4cc64423e9899dba6115a26c9.json"}}], "type": "journal article", "published": "2022-10-01", "journal": {"title": "Biochim Biophys Acta Biomembr", "issn": "1879-2642", "issn-l": null, "volume": "1864", "issue": "10", "pages": "183994"}, "abstract": "SARS-CoV-2 contains four structural proteins in its genome. These proteins aid in the assembly and budding of new virions at the ER-Golgi intermediate compartment (ERGIC). Current fundamental research efforts largely focus on one of these proteins - the spike (S) protein. Since successful antiviral therapies are likely to target multiple viral components, there is considerable interest in understanding the biophysical role of its other structural proteins, in particular structural membrane proteins. Here, we have focused our efforts on the characterization of the full-length envelope (E) protein from SARS-CoV-2, combining experimental and computational approaches. Recombinant expression of the full-length E protein from SARS-CoV-2 reveals that this membrane protein is capable of independent multimerization, possibly as a tetrameric or smaller species. Fluorescence microscopy shows that the protein localizes intracellularly, and coarse-grained MD simulations indicate it causes bending of the surrounding lipid bilayer, corroborating a potential role for the E protein in viral budding. Although we did not find robust electrophysiological evidence of ion-channel activity, cells transfected with the E protein exhibited reduced intracellular Ca2+, which may further promote viral replication. However, our atomistic MD simulations revealed that previous NMR structures are relatively unstable, and result in models incapable of ion conduction. Our study highlights the importance of using high-resolution structural data obtained from a full-length protein to gain detailed molecular insights, and eventually permitting virtual drug screening.", "doi": "10.1016/j.bbamem.2022.183994", "pmid": "35724739", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: VR": null, "Category: Imaging": null, "Funder: KAW/SciLifeLab": null, "Research Area: Drug discovery and repurposing of drugs": null}, "xrefs": [{"db": "pmc", "key": "PMC9212275"}, {"db": "pii", "key": "S0005-2736(22)00132-8"}], "notes": [], "created": "2022-08-15T13:04:26.500Z", "modified": "2023-10-04T08:21:52.816Z"}, {"entity": "publication", "iuid": "23211eab6ea84a5cb42fac597ead9172", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23211eab6ea84a5cb42fac597ead9172.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23211eab6ea84a5cb42fac597ead9172"}}, "title": "Association of COVID-19 Infection With Wearing Glasses in a High-Prevalence Area in Denmark and Sweden.", "authors": [{"family": "Gregersen", "given": "Rasmus", "initials": "R"}, {"family": "Jacobsen", "given": "Rikke Kart", "initials": "RK"}, {"family": "Laursen", "given": "Jannie", "initials": "J"}, {"family": "Mobech", "given": "Regine", "initials": "R"}, {"family": "Ostrowski", "given": "Sisse Rye", "initials": "SR"}, {"family": "Iversen", "given": "Kasper", "initials": "K"}, {"family": "Petersen", "given": "Janne", "initials": "J"}], "type": "journal article", "published": "2022-10-01", "journal": {"title": "JAMA Ophthalmol", "issn": "2168-6173", "volume": "140", "issue": "10", "pages": "957-964", "issn-l": null}, "abstract": "Observational studies have indicated that glasses might protect against contracting COVID-19 through reduced airborne and contact transmission.\n\nTo investigate the association between wearing one's own glasses with contracting COVID-19 when adjusting for relevant confounders.\n\nThis cohort study was conducted during the first wave of the COVID-19 pandemic (June to August 2020) in Denmark and Sweden, where personal protective equipment was not recommended for the general population at the time. Employees at Falck, an international rescue corps with different job functions (ambulance, health care, office, and field staff, firefighters, and roadside assistance) participated in the study.\n\nThe main exposure was wearing glasses (also including contact lenses and reading glasses), which was assessed in a questionnaire. Persons wearing glasses were compared with those who did not wear glasses (ie, nonusers). To adjust for potential confounders, information on age, sex, job function, and number of workday contacts were included.\n\nThe outcome was COVID-19 infection before (positive polymerase chain reaction test) or during the study period (biweekly voluntary tests with a rapid test). The investigated hypothesis was formulated after collecting the data.\n\nA total of 1279 employees in Denmark and 841 in Sweden were included (839 [39.6%] female and 1281 [60.4%] male; 20.5% were aged <40 years; 57.0%, 40-60 years, and 22.5%, >60 years). Of these, 829 individuals (64.8%) in Denmark and 619 (73.6%) in Sweden wore glasses. Wearing glasses was inversely associated with COVID-19 infection in the Swedish cohort (odds ratio [OR], 0.61 [95% CI, 0.37-0.99]; P = .047; seroprevalence, 9.3%) but not in the Danish cohort (OR, 1.14 [95% CI, 0.53-2.45]; P = .73; seroprevalence, 2.4%). Adjusting for age, sex, job function, and number of workday contacts in Sweden, wearing glasses no longer was associated with COVID-19 infection (OR, 0.64 [95% CI, 0.37-1.11]; P = .11). When stratifying by job function, a large difference was observed among office staff (OR, 0.20 [95% CI, 0.06-0.70]; P = .01) but not ambulance staff (OR, 0.83 [95% CI, 0.41-1.67]; P = .60) nor health care staff (OR, 0.89 [95% CI, 0.35-2.30]; P = .81).\n\nWhile wearing one's glasses was inversely associated with COVID-19 in Sweden in an unadjusted analysis, an association no longer was identified when adjusting for confounders. These results provide inconclusive findings regarding whether wearing one's own glasses is associated with a decreased risk of COVID-19 infections.", "doi": "10.1001/jamaophthalmol.2022.3234", "pmid": "36006635", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9412836"}, {"db": "pii", "key": "2795676"}], "notes": [], "created": "2022-08-26T04:42:09.969Z", "modified": "2023-01-13T13:33:16.749Z"}, {"entity": "publication", "iuid": "ae405af650f2480a8b7b65aee874a1ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ae405af650f2480a8b7b65aee874a1ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ae405af650f2480a8b7b65aee874a1ae"}}, "title": "Years of life lost during the Covid-19 pandemic in Sweden considering variation in life expectancy by level of geriatric care.", "authors": [{"family": "Ebeling", "given": "Marcus", "initials": "M", "orcid": "0000-0002-6531-8525", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68c1d52cda8f44b08a880cff988da4fe.json"}}, {"family": "Acosta", "given": "Enrique", "initials": "E", "orcid": "0000-0001-6250-4018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58eb2562f719445ca58bbe4767ff3c05.json"}}, {"family": "Caswell", "given": "Hal", "initials": "H", "orcid": "0000-0003-4394-6894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cc33d38bae1411d99d1cb998c10b407.json"}}, {"family": "Meyer", "given": "Anna C", "initials": "AC", "orcid": "0000-0003-2749-7179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/85b259806e24408cba7ef935931c0cc9.json"}}, {"family": "Modig", "given": "Karin", "initials": "K", "orcid": "0000-0002-5151-4867", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b60a410c326c43df8256b3ffd7cd38d4.json"}}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "Eur J Epidemiol", "issn": "1573-7284", "volume": "37", "issue": "10", "pages": "1025-1034", "issn-l": "0393-2990"}, "abstract": "The Covid-19 pandemic has not affected the population evenly. This must be acknowledged when it comes to understanding the Covid-19 death toll and answering the question of how many life years have been lost. We use level of geriatric care to account for variation in remaining life expectancy among individuals that died during 2020. Based on a linkage of administrative registers, we estimate remaining life expectancy stratified by age, sex, and care status using an incidence-based multistate model and analyze the number of years of life lost (YLL) during 2020 in Sweden. Our results show that remaining life expectancy between individuals with and without care differs substantially. More than half of all Covid-19 deaths had a remaining life expectancy lower than 4 years. Yet, in a 1-year perspective, Covid-19 did not seem to replace other causes of death. Not considering the differences in remaining life expectancy in the affected populations overestimated YLL by 40% for women and 30% for men, or around 2 years per death. While the unadjusted YLL from Covid-19 amounted to an average of 7.5 years for women and 8.6 years for men, the corresponding YLL adjusted for care status were 5.4 and 6.6, respectively. The total number of YLL to Covid-19 in 2020 is comparable to YLL from ischemic heart disease in 2019 and 2020. Our results urge the use of subgroup specific mortality when counting the burden of Covid-19. YLL are considerably reduced when the varying susceptibility for death is considered, but even if most lifespans were cut in the last years of life, the YLL are still substantial.", "doi": "10.1007/s10654-022-00915-z", "pmid": "36127511", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9488891"}, {"db": "pii", "key": "10.1007/s10654-022-00915-z"}], "notes": [], "created": "2023-01-13T13:53:50.160Z", "modified": "2023-01-13T13:53:50.311Z"}, {"entity": "publication", "iuid": "43e0662d439441f38ff4e351cb71c5e0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/43e0662d439441f38ff4e351cb71c5e0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/43e0662d439441f38ff4e351cb71c5e0"}}, "title": "The Dual Pandemics of COVID-19 and Obesity: Bidirectional Impact.", "authors": [{"family": "Kapoor", "given": "Nitin", "initials": "N"}, {"family": "Kalra", "given": "Sanjay", "initials": "S"}, {"family": "Al Mahmeed", "given": "Wael", "initials": "W"}, {"family": "Al-Rasadi", "given": "Khalid", "initials": "K"}, {"family": "Al-Alawi", "given": "Kamila", "initials": "K"}, {"family": "Banach", "given": "Maciej", "initials": "M"}, {"family": "Banerjee", "given": "Yajnavalka", "initials": "Y"}, {"family": "Ceriello", "given": "Antonio", "initials": "A"}, {"family": "Cesur", "given": "Mustafa", "initials": "M"}, {"family": "Cosentino", "given": "Francesco", "initials": "F"}, {"family": "Firenze", "given": "Alberto", "initials": "A"}, {"family": "Galia", "given": "Massimo", "initials": "M"}, {"family": "Goh", "given": "Su-Yen", "initials": "S"}, {"family": "Janez", "given": "Andrej", "initials": "A"}, {"family": "Kempler", "given": "Peter", "initials": "P"}, {"family": "Lessan", "given": "Nader", "initials": "N"}, {"family": "Lotufo", "given": "Paulo", "initials": "P"}, {"family": "Papanas", "given": "Nikolaos", "initials": "N"}, {"family": "Rizvi", "given": "Ali A", "initials": "AA"}, {"family": "Sahebkar", "given": "Amirhossein", "initials": "A"}, {"family": "Santos", "given": "Raul D", "initials": "RD"}, {"family": "Stoian", "given": "Anca Pantea", "initials": "AP"}, {"family": "Toth", "given": "Peter P", "initials": "PP"}, {"family": "Viswanathan", "given": "Vijay", "initials": "V"}, {"family": "Rizzo", "given": "Manfredi", "initials": "M"}, {"family": "CArdiometabolic Panel of International experts on Syndemic COvid-19 (CAPISCO)", "given": "", "initials": ""}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "Diabetes Ther", "issn": "1869-6953", "issn-l": null, "volume": "13", "issue": "10", "pages": "1723-1736"}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the COVID-19 pandemic, has been shown to disrupt many organ systems in the human body. Though several medical disorders have been affected by this infection, a few illnesses in addition may also play a role in determining the outcome of COVID-19. Obesity is one such disease which is not only affected by the occurrence of COVID-19 but can also result in a worse clinical outcome of COVID-19 infection. This manuscript summarizes the most recent evidence supporting the bidirectional impact of COVID-19 and obesity. It highlights how the presence of obesity can be detrimental to the outcome of COVID-19 in a given patient because of the mechanical limitations in lung compliance and also by the activation of several thrombo-inflammatory pathways. The sociodemographic changes brought about by the pandemic in turn have facilitated the already increasing prevalence of obesity. This manuscript highlights the importance of recognizing these pathways which may further help in policy changes that facilitate appropriate measures to prevent the further worsening of these two pandemics.", "doi": "10.1007/s13300-022-01311-2", "pmid": "36030317", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s13300-022-01311-2"}, {"db": "pmc", "key": "PMC9419639"}], "notes": [], "created": "2022-10-07T12:40:52.100Z", "modified": "2022-10-07T12:41:32.075Z"}, {"entity": "publication", "iuid": "0a56301865724fb4907f0e0c27be5a82", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a56301865724fb4907f0e0c27be5a82.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a56301865724fb4907f0e0c27be5a82"}}, "title": "Severity of COVID19 infection among patients with multiple sclerosis treated with interferon-\u03b2.", "authors": [{"family": "Simpson-Yap", "given": "Steve", "initials": "S", "orcid": "0000-0001-6521-3056", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/845cbea3a2f64b9f880a43d6cc8cdb09.json"}}, {"family": "Pirmani", "given": "Ashkan", "initials": "A"}, {"family": "De Brouwer", "given": "Edward", "initials": "E"}, {"family": "Peeters", "given": "Liesbet M", "initials": "LM"}, {"family": "Geys", "given": "Lotte", "initials": "L"}, {"family": "Parciak", "given": "Tina", "initials": "T"}, {"family": "Helme", "given": "Anne", "initials": "A"}, {"family": "Hillert", "given": "Jan", "initials": "J"}, {"family": "Moreau", "given": "Yves", "initials": "Y"}, {"family": "Edan", "given": "Gilles", "initials": "G"}, {"family": "Spelman", "given": "Tim", "initials": "T"}, {"family": "Sharmin", "given": "Sifat", "initials": "S"}, {"family": "McBurney", "given": "Robert", "initials": "R"}, {"family": "Schmidt", "given": "Hollie", "initials": "H"}, {"family": "Bergmann", "given": "Arnfin", "initials": "A"}, {"family": "Braune", "given": "Stefan", "initials": "S"}, {"family": "Stahmann", "given": "Alexander", "initials": "A"}, {"family": "Middleton", "given": "Rodden", "initials": "R"}, {"family": "Salter", "given": "Amber", "initials": "A"}, {"family": "Bebo", "given": "Bruce", "initials": "B"}, {"family": "van der Walt", "given": "Anneke", "initials": "A"}, {"family": "Butzkueven", "given": "Helmut", "initials": "H"}, {"family": "Ozakbas", "given": "Serkan", "initials": "S"}, {"family": "Karabudak", "given": "Rana", "initials": "R"}, {"family": "Boz", "given": "Cavit", "initials": "C"}, {"family": "Alroughani", "given": "Raed", "initials": "R"}, {"family": "Rojas", "given": "Juan I", "initials": "JI"}, {"family": "van der Mei", "given": "Ingrid", "initials": "I"}, {"family": "Sciascia do Olival", "given": "Guilherme", "initials": "G"}, {"family": "Magyari", "given": "Melinda", "initials": "M"}, {"family": "Alonso", "given": "Ricardo", "initials": "R"}, {"family": "Nicholas", "given": "Richard", "initials": "R"}, {"family": "Chertcoff", "given": "Anibal", "initials": "A"}, {"family": "Zabalza", "given": "Ana", "initials": "A"}, {"family": "Arrambide", "given": "Georgina", "initials": "G"}, {"family": "Nag", "given": "Nupur", "initials": "N"}, {"family": "Descamps", "given": "Annabel", "initials": "A"}, {"family": "Costers", "given": "Lars", "initials": "L"}, {"family": "Dobson", "given": "Ruth", "initials": "R"}, {"family": "Miller", "given": "Aleisha", "initials": "A"}, {"family": "Rodrigues", "given": "Paulo", "initials": "P"}, {"family": "Pr\u010dkovska", "given": "Vesna", "initials": "V"}, {"family": "Comi", "given": "Giancarlo", "initials": "G"}, {"family": "Kalincik", "given": "Tomas", "initials": "T"}], "type": "letter", "published": "2022-10-00", "journal": {"title": "Mult Scler Relat Disord", "issn": "2211-0356", "volume": "66", "pages": "104072", "issn-l": null}, "abstract": "Interferon-\u03b2, a disease-modifying therapy (DMT) for MS, may be associated with less severe COVID-19 in people with MS.\n\nAmong 5,568 patients (83.4% confirmed COVID-19), interferon-treated patients had lower risk of severe COVID-19 compared to untreated, but not to glatiramer-acetate, dimethyl-fumarate, or pooled other DMTs.\n\nIn comparison to other DMTs, we did not find evidence of protective effects of interferon-\u03b2 on the severity of COVID-19, though compared to the untreated, the course of COVID19 was milder among those on interferon-\u03b2. This study does not support the use of interferon-\u03b2 as a treatment to reduce COVID-19 severity in MS.", "doi": "10.1016/j.msard.2022.104072", "pmid": "35917745", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9310378"}, {"db": "pii", "key": "S2211-0348(22)00580-6"}], "notes": [], "created": "2022-08-11T12:02:34.852Z", "modified": "2023-06-19T14:41:22.654Z"}, {"entity": "publication", "iuid": "125837694ec841ec8b0ab596b5e550a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/125837694ec841ec8b0ab596b5e550a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/125837694ec841ec8b0ab596b5e550a6"}}, "title": "Severe COVID-19 in people 55 and older during the first year of the pandemic in Sweden.", "authors": [{"family": "Rosengren", "given": "Annika", "initials": "A"}, {"family": "Lundberg", "given": "Christina E", "initials": "CE"}, {"family": "S\u00f6derberg", "given": "Mia", "initials": "M"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Edqvist", "given": "Jon", "initials": "J"}, {"family": "Lindgren", "given": "Martin", "initials": "M"}, {"family": "\u00c5berg", "given": "Maria", "initials": "M"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Robertson", "given": "Josefina", "initials": "J"}, {"family": "Cronie", "given": "Ottmar", "initials": "O"}, {"family": "Sattar", "given": "Naveed", "initials": "N"}, {"family": "Lagergren", "given": "Jesper", "initials": "J"}, {"family": "Brand\u00e9n", "given": "Maria", "initials": "M"}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}, {"family": "Adiels", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": "292", "issue": "4", "pages": "641-653"}, "abstract": "Exposure to many contacts is the main risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, while risk of serious disease and death is chiefly determined by old age and comorbidities. Relative and population-attributable fractions (PAFs) of multiple medical and social exposures for COVID-19 outcomes have not been evaluated among older adults.\r\n\r\nWe describe the effect of multiple exposures on the odds of testing positive for the virus and of severe disease (hospital care or death) and PAFs in Swedish citizens aged 55 years and above.\r\n\r\nWe used national registers to follow all citizens aged 55 years and above with respect to (1) testing positive, (2) hospitalization, and (3) death between 31 January 2020 and 1 February 2021.\r\n\r\nOf 3,410,241 persons, 156,017 (4.6%, mean age 68.3 years) tested positive for SARS-CoV-2, while 35,999 (1.1%, mean age 76.7 years) were hospitalized or died (12,384 deaths, 0.4%, mean age 84.0 years). Among the total cohort, the proportion living without home care or long-term care was 98.8% among persons aged 55-64 and 22.1% of those aged 95 and above. After multiple adjustment, home care and long-term care were associated with odds ratios of 7.9 (95% confidence interval [CI] 6.8-9.1) and 22.5 (95% CI 19.6-25.7) for mortality, with PAFs of 21.9% (95% CI 20.9-22.9) and 33.3% (95% CI 32.4-34.3), respectively.\r\n\r\nAmong Swedish residents aged 55 years and above, those with home care or long-term care had markedly increased risk for COVID-19 death during the first year of the pandemic, with over 50% of deaths attributable to these factors.", "doi": "10.1111/joim.13522", "pmid": "35612518", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC9348046"}], "notes": [], "created": "2022-06-21T17:51:17.657Z", "modified": "2022-10-13T14:39:34.245Z"}, {"entity": "publication", "iuid": "c247a0d7b8c6418b9ab769b6a49da500", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c247a0d7b8c6418b9ab769b6a49da500.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c247a0d7b8c6418b9ab769b6a49da500"}}, "title": "SARS-CoV-2 spike protein aggregation is triggered by bacterial lipopolysaccharide.", "authors": [{"family": "Petrlova", "given": "Jitka", "initials": "J", "orcid": "0000-0002-7554-3945", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a58aee20cb4847d99c9b307c76fdda74.json"}}, {"family": "Samsudin", "given": "Firdaus", "initials": "F"}, {"family": "Bond", "given": "Peter J", "initials": "PJ"}, {"family": "Schmidtchen", "given": "Artur", "initials": "A", "orcid": "0000-0001-9209-3141", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/426e00c7c8314ea195f2670af469e19a.json"}}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "FEBS Lett", "issn": "1873-3468", "volume": "596", "issue": "19", "pages": "2566-2575", "issn-l": null}, "abstract": "SARS-CoV-2 spike (S) protein is crucial for virus invasion in COVID-19. Here, we showed that lipopolysaccharide (LPS) can trigger S protein aggregation at high doses of LPS and S protein. We demonstrated the formation of S protein aggregates by microscopy analyses, aggregation and gel shift assays. LPS at high levels boosts the formation of S protein aggregates as detected by amytracker and thioflavin T dyes that specifically bind to aggregating proteins. We validated the role of LPS by blocking the formation of aggregates by the endotoxin-scavenging thrombin-derived peptide TCP-25. Aggregation-prone sequences in S protein are predicted to be nearby LPS binding sites, while molecular simulations showed stable formation of S protein-LPS higher-order oligomers. Collectively, our results provide evidence of LPS-induced S protein aggregation.", "doi": "10.1002/1873-3468.14490", "pmid": "36050806", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9538650"}], "notes": [], "created": "2022-10-13T13:15:42.794Z", "modified": "2022-10-13T13:17:51.776Z"}, {"entity": "publication", "iuid": "9a98809b3327409e8e37fc73fd45ad63", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9a98809b3327409e8e37fc73fd45ad63.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9a98809b3327409e8e37fc73fd45ad63"}}, "title": "No effect of remdesivir or betamethasone on upper respiratory tract SARS-CoV-2 RNA kinetics in hospitalised COVID-19 patients: a retrospective observational study.", "authors": [{"family": "Sourander", "given": "Birger", "initials": "B"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "L"}, {"family": "Brink", "given": "Magnus", "initials": "M"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Sundell", "given": "Nicklas", "initials": "N"}, {"family": "Marklund", "given": "Emelie", "initials": "E"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Robertson", "given": "Josefina", "initials": "J"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": "54", "issue": "10", "pages": "703-712"}, "abstract": "The viral kinetics of SARS-CoV-2 has been considered clinically important. While remdesivir and corticosteroids are recommended for COVID-19 patients requiring oxygen support, there is a limited number of published reports on viral kinetics in hospitalised patients with COVID-19 treated with remdesivir or corticosteroids.\r\n\r\nWe conducted a retrospective study by collecting longitudinal samples from the nasopharynx/throat of 123 hospitalised patients (median age 55 years, 74% male) with COVID-19, to evaluate the effects of remdesivir and corticosteroid treatment on viral RNA levels. The subjects were divided into four groups: those receiving remdesivir (n = 25), betamethasone (n = 41), both (n = 15), or neither (n = 42). Time to viral RNA clearance was analysed using Kaplan-Meier plots, categorical data were analysed using Fisher's exact test, and Kruskal-Wallis for continuous data. Viral RNA decline rate was analysed using a mixed effect model.\r\n\r\nWe found no significant difference in SARS-CoV-2 RNA decline rate or time to SARS-CoV-2 RNA clearance between the groups. Moreover, clinical status at baseline was not correlated with time to viral clearance.\r\n\r\nSince SARS-CoV-2 RNA kinetics was not affected by treatment, repeated sampling from the upper respiratory tract cannot be used to evaluate treatment response.", "doi": "10.1080/23744235.2022.2081716", "pmid": "35708280", "labels": {"Category: Drug Discovery": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2022-06-20T18:10:19.043Z", "modified": "2022-10-13T14:40:38.264Z"}, {"entity": "publication", "iuid": "a59e71c204fc4f40a3f4d5c31324c22b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a59e71c204fc4f40a3f4d5c31324c22b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a59e71c204fc4f40a3f4d5c31324c22b"}}, "title": "Infection Rate of SARS-CoV-2 in Asymptomatic Healthcare Workers, Sweden, June 2022.", "authors": [{"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Norin", "given": "Nina Greilert", "initials": "NG"}, {"family": "Bacchus", "given": "Philip", "initials": "P"}, {"family": "Groenheit", "given": "Ramona", "initials": "R"}, {"family": "Br\u00e5ve", "given": "Andreas", "initials": "A"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}], "type": "letter", "published": "2022-10-00", "journal": {"title": "Emerg Infect Dis", "issn": "1080-6059", "volume": "28", "issue": "10", "pages": "2119-2121", "issn-l": null}, "abstract": "Given the recent surge in SARS-CoV-2 Omicron infections, we performed a quantitative PCR screening survey during June 28-29, 2022, in Stockholm, Sweden, to investigate SARS-CoV-2 point prevalence in a group with high exposure risk. Results showed SARS-CoV-2 infection in 2.3% of healthcare workers who were asymptomatic at time of sampling.", "doi": "10.3201/eid2810.221093", "pmid": "35997692", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9514358"}], "notes": [], "created": "2022-08-26T04:45:09.756Z", "modified": "2023-06-19T14:27:18.248Z"}, {"entity": "publication", "iuid": "01c40c37457844aabd726103ec1267ba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01c40c37457844aabd726103ec1267ba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01c40c37457844aabd726103ec1267ba"}}, "title": "Induced abortion and access to contraception in Sweden during the COVID-19 pandemic.", "authors": [{"family": "Niemeyer Hultstrand", "given": "Jenny", "initials": "J", "orcid": "0000-0002-2304-2006", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/abc93f26a58947fea94714306129d45d.json"}}, {"family": "T\u00f6rnroos", "given": "Elin", "initials": "E"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}, {"family": "Larsson", "given": "Margareta I", "initials": "MI"}, {"family": "Makenzius", "given": "Marlene", "initials": "M"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Tyd\u00e9n", "given": "Tanja", "initials": "T"}, {"family": "Ekstrand Ragnar", "given": "Maria", "initials": "M"}], "type": "letter", "published": "2022-10-00", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-2009", "volume": "48", "issue": "4", "pages": "311-312", "issn-l": "2515-1991"}, "abstract": null, "doi": "10.1136/bmjsrh-2022-201464", "pmid": "35332034", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjsrh-2022-201464"}], "notes": [], "created": "2022-04-04T06:58:49.184Z", "modified": "2023-01-13T13:34:18.406Z"}, {"entity": "publication", "iuid": "ac4ad25a4acc4c9ea992394d22cb4c67", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac4ad25a4acc4c9ea992394d22cb4c67.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac4ad25a4acc4c9ea992394d22cb4c67"}}, "title": "Desire to work from home: Results of an Irish study.", "authors": [{"family": "Stefaniec", "given": "Agnieszka", "initials": "A"}, {"family": "Brazil", "given": "William", "initials": "W"}, {"family": "Whitney", "given": "Warren", "initials": "W"}, {"family": "Caulfield", "given": "Brian", "initials": "B"}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "J Transp Geogr", "issn": "0966-6923", "issn-l": null, "volume": "104", "issue": null, "pages": "103416"}, "abstract": "Large levels of working from home (WfH) were induced by social distancing and viral control measures undertaken to mitigate the Covid-19 pandemic. Representing an unpredicted change in the way large amounts of people undertake their day to day work, it is expected that the legacy of this event, in terms of significant alterations to work and commuting patterns will have wide-ranging and long-lasting results. However, how persistent the current trends will be, remains an open question. Therefore, there is a need for a well-represented study of employees' preferences for the post-pandemic future and focus on white-collar workers and their well-established attitudes considering their flexibility in terms of workplace arrangements. This paper presents the results of a survey undertaken in Ireland in the summer of 2021 gauging the desire of office workers to WfH, the format that most appeals to them, the consideration of home relocation based on the ability to WfH, and the factors that may explain such preferences. Results indicate high levels of desire to WfH, either full time or partially, with increased desire to WfH positively correlated to pre-pandemic commute length, and to a perceived increase in work productivity and quality of non-work life as a result of time spent WfH. Additionally, a number of workers state that they may consider home relocation based upon the ability to WfH. These results should be interpreted as the desire to WfH or total addressable market that exists, rather than the likely levels of WfH that will be observed post-Covid.", "doi": "10.1016/j.jtrangeo.2022.103416", "pmid": "35992220", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0966-6923(22)00139-9"}, {"db": "pmc", "key": "PMC9379795"}], "notes": [], "created": "2022-09-12T18:52:28.755Z", "modified": "2022-11-09T08:36:41.448Z"}, {"entity": "publication", "iuid": "3239af756d1f41f3bbfd495afcec99d3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3239af756d1f41f3bbfd495afcec99d3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3239af756d1f41f3bbfd495afcec99d3"}}, "title": "Comprehensive analysis of pathways in Coronavirus 2019 (COVID-19) using an unsupervised machine learning method.", "authors": [{"family": "Taheri", "given": "Golnaz", "initials": "G"}, {"family": "Habibi", "given": "Mahnaz", "initials": "M"}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "Appl Soft Comput", "issn": "1568-4946", "volume": "128", "pages": "109510", "issn-l": null}, "abstract": "The World Health Organization (WHO) introduced \"Coronavirus disease 19\" or \"COVID-19\" as a novel coronavirus in March 2020. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires the fast discovery of effective treatments to fight this worldwide crisis. Artificial intelligence and bioinformatics analysis pipelines can assist with finding biomarkers, explanations, and cures. Artificial intelligence and machine learning methods provide powerful infrastructures for interpreting and understanding the available data. On the other hand, pathway enrichment analysis, as a dominant tool, could help researchers discover potential key targets present in biological pathways of host cells that are targeted by SARS-CoV-2. In this work, we propose a two-stage machine learning approach for pathway analysis. During the first stage, four informative gene sets that can represent important COVID-19 related pathways are selected. These \"representative genes\" are associated with the COVID-19 pathology. Then, two distinctive networks were constructed for COVID-19 related signaling and disease pathways. In the second stage, the pathways of each network are ranked with respect to some unsupervised scorning method based on our defined informative features. Finally, we present a comprehensive analysis of the top important pathways in both networks. Materials and implementations are available at: https://github.com/MahnazHabibi/Pathway.", "doi": "10.1016/j.asoc.2022.109510", "pmid": "35992221", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1568-4946(22)00596-8"}, {"db": "pmc", "key": "PMC9384336"}], "notes": [], "created": "2022-09-12T18:52:34.765Z", "modified": "2022-09-12T18:52:44.843Z"}, {"entity": "publication", "iuid": "2d1ee9ca5d6e413c8099707e881b182c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d1ee9ca5d6e413c8099707e881b182c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d1ee9ca5d6e413c8099707e881b182c"}}, "title": "CODE-EHR best-practice framework for the use of structured electronic health-care records in clinical research.", "authors": [{"family": "Kotecha", "given": "Dipak", "initials": "D"}, {"family": "Asselbergs", "given": "Folkert W", "initials": "FW"}, {"family": "Achenbach", "given": "Stephan", "initials": "S"}, {"family": "Anker", "given": "Stefan D", "initials": "SD"}, {"family": "Atar", "given": "Dan", "initials": "D"}, {"family": "Baigent", "given": "Colin", "initials": "C"}, {"family": "Banerjee", "given": "Amitava", "initials": "A"}, {"family": "Beger", "given": "Birgit", "initials": "B"}, {"family": "Brobert", "given": "Gunnar", "initials": "G"}, {"family": "Casadei", "given": "Barbara", "initials": "B"}, {"family": "Ceccarelli", "given": "Cinzia", "initials": "C"}, {"family": "Cowie", "given": "Martin R", "initials": "MR"}, {"family": "Crea", "given": "Filippo", "initials": "F"}, {"family": "Cronin", "given": "Maureen", "initials": "M"}, {"family": "Denaxas", "given": "Spiros", "initials": "S"}, {"family": "Derix", "given": "Andrea", "initials": "A"}, {"family": "Fitzsimons", "given": "Donna", "initials": "D"}, {"family": "Fredriksson", "given": "Martin", "initials": "M"}, {"family": "Gale", "given": "Chris P", "initials": "CP"}, {"family": "Gkoutos", "given": "Georgios V", "initials": "GV"}, {"family": "Goettsch", "given": "Wim", "initials": "W"}, {"family": "Hemingway", "given": "Harry", "initials": "H"}, {"family": "Ingvar", "given": "Martin", "initials": "M"}, {"family": "Jonas", "given": "Adrian", "initials": "A"}, {"family": "Kazmierski", "given": "Robert", "initials": "R"}, {"family": "L\u00f8gstrup", "given": "Susanne", "initials": "S"}, {"family": "Lumbers", "given": "R Thomas", "initials": "RT"}, {"family": "L\u00fcscher", "given": "Thomas F", "initials": "TF"}, {"family": "McGreavy", "given": "Paul", "initials": "P"}, {"family": "Pi\u00f1a", "given": "Ileana L", "initials": "IL"}, {"family": "Roessig", "given": "Lothar", "initials": "L"}, {"family": "Steinbeisser", "given": "Carl", "initials": "C"}, {"family": "Sundgren", "given": "Mats", "initials": "M"}, {"family": "Tyl", "given": "Beno\u00eet", "initials": "B"}, {"family": "Thiel", "given": "Ghislaine van", "initials": "GV"}, {"family": "Bochove", "given": "Kees van", "initials": "KV"}, {"family": "Vardas", "given": "Panos E", "initials": "PE"}, {"family": "Villanueva", "given": "Tiago", "initials": "T"}, {"family": "Vrana", "given": "Marilena", "initials": "M"}, {"family": "Weber", "given": "Wim", "initials": "W"}, {"family": "Weidinger", "given": "Franz", "initials": "F"}, {"family": "Windecker", "given": "Stephan", "initials": "S"}, {"family": "Wood", "given": "Angela", "initials": "A"}, {"family": "Grobbee", "given": "Diederick E", "initials": "DE"}, {"family": "Innovative Medicines Initiative BigData@Heart Consortium, European Society of Cardiology, and CODE-EHR International Consensus Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "The Lancet Digital Health", "issn": "2589-7500", "volume": "4", "issue": "10", "pages": "e757-e764", "issn-l": null}, "abstract": "Big data is important to new developments in global clinical science that aim to improve the lives of patients. Technological advances have led to the regular use of structured electronic health-care records with the potential to address key deficits in clinical evidence that could improve patient care. The COVID-19 pandemic has shown this potential in big data and related analytics but has also revealed important limitations. Data verification, data validation, data privacy, and a mandate from the public to conduct research are important challenges to effective use of routine health-care data. The European Society of Cardiology and the BigData@Heart consortium have brought together a range of international stakeholders, including representation from patients, clinicians, scientists, regulators, journal editors, and industry members. In this Review, we propose the CODE-EHR minimum standards framework to be used by researchers and clinicians to improve the design of studies and enhance transparency of study methods. The CODE-EHR framework aims to develop robust and effective utilisation of health-care data for research purposes.", "doi": "10.1016/S2589-7500(22)00151-0", "pmid": "36050271", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2589-7500(22)00151-0"}], "notes": [], "created": "2022-10-13T13:06:28.143Z", "modified": "2022-10-13T13:06:28.156Z"}, {"entity": "publication", "iuid": "0f906486a40f462c9c666a0a0e72b164", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0f906486a40f462c9c666a0a0e72b164.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0f906486a40f462c9c666a0a0e72b164"}}, "title": "Favorable Adaptation during SARS-CoV-2-Pandemic as Told by Student-Athletes-A Longitudinal and Behavioral Study.", "authors": [{"family": "Johnson", "given": "Urban", "initials": "U"}, {"family": "Hertting", "given": "Krister", "initials": "K", "orcid": "0000-0003-2347-4391", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98fbb192394e443c8f3feeee090189fe.json"}}, {"family": "Ivarsson", "given": "Andreas", "initials": "A"}, {"family": "Lindgren", "given": "Eva-Carin", "initials": "E"}], "type": "journal article", "published": "2022-09-30", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "19", "issue": "19", "pages": null}, "abstract": "(1) Background: The aim was to explore the impact of adaptive responses (resilience factors) on student-athletes' behaviors during a stressful period of life during the SARS-CoV-2-pandemic of 2020 and 2021. (2) Methods: A constructivist-based grounded theory (CGT) was used guided by a biopsychosocial approach. Based on purposeful sampling, 22 male and female student-athletes were divided into four focus group interviews (FGI) seven months after the outbreak of the SARS-CoV-2-pandemic (October 2020) and 18 of these were followed up by FGI seven months later (May 2021). The mean age was 17.65 and they represented golf and handball. (3) Results: The CGT contained four main categories seven months after the SARS-CoV-2-pandemic outbreak: Social support, Self-discipline, Physical practice and recovery and Management of everyday life. Fourteen months after the SARS-CoV-2-pandemic outbreak, four additional main categories emerged: More extensive social support, Belief in the future, Self-awareness and Responsibility and problem-solving. (4) Conclusions: The CTG suggests that student-athletes' favorable adaptations to the stressful SARS-CoV-2-pandemic period 2020-2021 are based on a gradually developed ability to take responsibility for one's own actions, insight into the importance of deepened social interaction, belief in a positive post-COVID future and increased awareness of physical activity and its relation to perceived health.", "doi": "10.3390/ijerph191912512", "pmid": "36231812", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph191912512"}], "notes": [], "created": "2022-10-17T14:56:32.227Z", "modified": "2022-10-17T14:57:00.351Z"}, {"entity": "publication", "iuid": "7783f0b4be54469c9768b72979029d95", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7783f0b4be54469c9768b72979029d95.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7783f0b4be54469c9768b72979029d95"}}, "title": "Strain on the ICU resources and patient outcomes in the COVID-19 pandemic: A Swedish national registry cohort study.", "authors": [{"family": "Stattin", "given": "Karl", "initials": "K"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Kawati", "given": "Rafael", "initials": "R"}], "type": "journal article", "published": "2022-09-27", "journal": {"title": "Eur J Anaesthesiol", "issn": "1365-2346", "issn-l": null}, "abstract": "The Coronavirus 2019 (COVID-19) pandemic has led to an unprecedented strain on the ICU resources. It is not known how the ICU resources employed in treating COVID-19 patients are related to inpatient characteristics, use of organ support or mortality.\n\nTo investigate how the use of ICU resources relate to use of organ support and mortality in COVID-19 patients.\n\nA national register-based cohort study.\n\nAll Swedish ICUs from March 2020 to November 2021.\n\nAll patients admitted to Swedish ICUs with a primary diagnosis of COVID-19 reported to the national Swedish Intensive Care Register (SIR).\n\nOrgan support (mechanical ventilation, noninvasive ventilation, high-flow oxygen therapy, prone positioning, surgical and percutaneous tracheostomy, central venous catheterisation, continuous renal replacement therapy and intermittent haemodialysis), discharge at night, re-admission, transfer and ICU and 30-day mortality.\n\nSeven thousand nine hundred and sixty-nine patients had a median age of 63 years, and 70% were men. Median daily census was 167% of habitual census, daily new admissions were 20% of habitual census and the median occupancy was 82%. Census and new admissions were associated with mechanical ventilation, OR 1.37 (95% CI 1.28 to 1.48) and OR 1.44 (95% CI 1.13 to 1.84), respectively, but negatively associated with noninvasive ventilation, OR 0.83 (95% CI 0.77 to 0.89) and OR 0.40 (95% CI 0.30 to 52) and high-flow oxygen therapy, OR 0.72 (95% CI 0.67 to 0.77) and OR 0.77 (95% CI 0.61 to 0.97). Occupancy above 90% of available beds was not associated with mechanical ventilation or noninvasive ventilation, but with high-flow oxygen therapy, OR 1.36 (95% CI 1.21 to 1.53). All measures of pressure on resources were associated with transfer to other hospitals, but none were associated with discharge at night, ICU mortality or 30-day mortality.\n\nPressure on ICU resources was associated with more invasive respiratory support, indicating that during these times, ICU resources were reserved for sicker patients.", "doi": "10.1097/EJA.0000000000001760", "pmid": "36156044", "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00003643-990000000-00037"}], "notes": [], "created": "2022-10-13T13:40:52.395Z", "modified": "2022-10-13T13:40:52.407Z"}, {"entity": "publication", "iuid": "1af31fe1dd4e4ce093745b83c68d4e4b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1af31fe1dd4e4ce093745b83c68d4e4b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1af31fe1dd4e4ce093745b83c68d4e4b"}}, "title": "A comparison of impact of comorbidities and demographics on 60-day mortality in ICU patients with COVID-19, sepsis and acute respiratory distress syndrome.", "authors": [{"family": "Ahlstr\u00f6m", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0001-9287-3607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0606fea9cd1048b99690f2e2823004ce.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Larsson", "given": "Ing-Marie", "initials": "I"}, {"family": "Strandberg", "given": "Gunnar", "initials": "G"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}], "type": "journal article", "published": "2022-09-20", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "12", "issue": "1", "pages": "15703"}, "abstract": "Severe Coronavirus disease 2019 (COVID-19) is associated with several pre-existing comorbidities and demographic factors. Similar factors are linked to critical sepsis and acute respiratory distress syndrome (ARDS). We hypothesized that age and comorbidities are more generically linked to critical illness mortality than a specific disease state. We used national databases to identify ICU patients and to retrieve comorbidities. The relative importance of risk factors for 60-day mortality was evaluated using the interaction with disease group (Sepsis, ARDS or COVID-19) in logistic regression models. We included 32,501 adult ICU patients. In the model on 60-day mortality in sepsis and COVID-19 there were significant interactions with disease group for age, sex and asthma. In the model on 60-day mortality in ARDS and COVID-19 significant interactions with cohort were found for acute disease severity, age and chronic renal failure. In conclusion, age and sex play particular roles in COVID-19 mortality during intensive care but the burden of comorbidity was similar between sepsis and COVID-19 and ARDS and COVID-19.", "doi": "10.1038/s41598-022-19539-0", "pmid": "36127433", "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-19539-0"}, {"db": "pmc", "key": "PMC9487845"}], "notes": [], "created": "2022-10-13T13:37:40.483Z", "modified": "2022-10-13T14:41:17.868Z"}, {"entity": "publication", "iuid": "17fb7d6b29a641868a32c5a8e7493ae5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/17fb7d6b29a641868a32c5a8e7493ae5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/17fb7d6b29a641868a32c5a8e7493ae5"}}, "title": "The amount of SARS-CoV-2 RNA in wastewater relates to the development of the pandemic and its burden on the health system.", "authors": [{"family": "Wang", "given": "Hao", "initials": "H"}, {"family": "Churqui", "given": "Marianela Patzi", "initials": "MP"}, {"family": "Tunovic", "given": "Timur", "initials": "T"}, {"family": "Enache", "given": "Lucica", "initials": "L"}, {"family": "Johansson", "given": "Anette", "initials": "A"}, {"family": "K\u00e4rmander", "given": "Ambj\u00f6rn", "initials": "A"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Dotevall", "given": "Leif", "initials": "L"}, {"family": "Brezicka", "given": "Thomas", "initials": "T"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Norder", "given": "Hel\u00e9ne", "initials": "H"}], "type": "journal article", "published": "2022-09-16", "journal": {"title": "iScience", "issn": "2589-0042", "volume": "25", "issue": "9", "pages": "105000", "issn-l": "2589-0042"}, "abstract": "Virus surveillance in wastewater can be a useful indicator of the development of the COVID-19 pandemic in communities. However, knowledge about how the amount of SARS-CoV-2 RNA in wastewater relates to different data on the burden on the health system is still limited. Herein, we monitored the amount of SARS-CoV-2 RNA and the spectrum of virus variants in weekly pooled wastewater samples for two years from mid-February 2020 and compared them with several clinical data. The two-year monitoring showed the weekly changes in the amount of viral RNA in wastewater preceded the hospital care needs for COVID-19 and the number of acute calls on adult acute respiratory distress by 1-2 weeks during the first three waves of COVID-19. Our study demonstrates that virus surveillance in wastewater can predict the development of a pandemic and its burden on the health system, regardless of society's test capacity and possibility of tracking infected cases.", "doi": "10.1016/j.isci.2022.105000", "pmid": "36035197", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(22)01272-X"}, {"db": "pmc", "key": "PMC9398557"}], "notes": [], "created": "2022-10-07T12:44:32.188Z", "modified": "2022-10-07T12:44:57.950Z"}, {"entity": "publication", "iuid": "198df304734544bd97b1dd4d65203aae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/198df304734544bd97b1dd4d65203aae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/198df304734544bd97b1dd4d65203aae"}}, "title": "Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination.", "authors": [{"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Cai", "given": "Curtis", "initials": "C"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Niessl", "given": "Julia", "initials": "J"}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Lange", "given": "Joshua", "initials": "J"}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Mielke", "given": "Stephan", "initials": "S"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "Vesterbacka", "given": "Jan", "initials": "J"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Perez-Potti", "given": "Andre", "initials": "A"}, {"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "M\u00fcller", "given": "Thomas R", "initials": "TR"}, {"family": "Boulouis", "given": "Caroline", "initials": "C"}, {"family": "Kammann", "given": "Tobias", "initials": "T"}, {"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Muvva", "given": "Jagadeeswara Rao", "initials": "JR"}, {"family": "Sobkowiak", "given": "Michal", "initials": "M"}, {"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "S\u00f6derdahl", "given": "Gunnar", "initials": "G"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Grifoni", "given": "Alba", "initials": "A"}, {"family": "Weiskopf", "given": "Daniela", "initials": "D"}, {"family": "Sette", "given": "Alessandro", "initials": "A"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}], "type": "journal article", "published": "2022-09-13", "journal": {"title": "Immunity", "issn": "1074-7613", "issn-l": null, "volume": "55", "issue": "9", "pages": "1732-1746.e5"}, "abstract": "Many immunocompromised patients mount suboptimal humoral immunity after SARS-CoV-2 mRNA vaccination. Here, we assessed the single-cell profile of SARS-CoV-2-specific T cells post-mRNA vaccination in healthy individuals and patients with various forms of immunodeficiencies. Impaired vaccine-induced cell-mediated immunity was observed in many immunocompromised patients, particularly in solid-organ transplant and chronic lymphocytic leukemia patients. Notably, individuals with an inherited lack of mature B cells, i.e., X-linked agammaglobulinemia (XLA) displayed highly functional spike-specific T cell responses. Single-cell RNA-sequencing further revealed that mRNA vaccination induced a broad functional spectrum of spike-specific CD4+ and CD8+ T cells in healthy individuals and patients with XLA. These responses were founded on polyclonal repertoires of CD4+ T cells and robust expansions of oligoclonal effector-memory CD45RA+ CD8+ T cells with stem-like characteristics. Collectively, our data provide the functional continuum of SARS-CoV-2-specific T cell responses post-mRNA vaccination, highlighting that cell-mediated immunity is of variable functional quality across immunodeficiency syndromes.", "doi": "10.1016/j.immuni.2022.07.005", "pmid": "35961317", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Research Area: Pandemic preparedness": null}, "xrefs": [{"db": "pmc", "key": "PMC9293955"}, {"db": "pii", "key": "S1074-7613(22)00338-7"}], "notes": [], "created": "2022-08-15T15:03:48.087Z", "modified": "2023-06-19T15:22:45.168Z"}, {"entity": "publication", "iuid": "914b9bc1bcef42d38359a1786dd84dcf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/914b9bc1bcef42d38359a1786dd84dcf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/914b9bc1bcef42d38359a1786dd84dcf"}}, "title": "Genetic and immunologic evaluation of children with inborn errors of immunity and severe or critical COVID-19.", "authors": [{"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Delavari", "given": "Samaneh", "initials": "S"}, {"family": "Landegren", "given": "Nils", "initials": "N"}, {"family": "Shokri", "given": "Sima", "initials": "S"}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Zuo", "given": "Fanglei", "initials": "F"}, {"family": "Hajebi", "given": "Reza", "initials": "R"}, {"family": "Abolnezhadian", "given": "Farhad", "initials": "F"}, {"family": "Iranparast", "given": "Sara", "initials": "S"}, {"family": "Modaresi", "given": "Mohammadreza", "initials": "M"}, {"family": "Vosughimotlagh", "given": "Ahmad", "initials": "A"}, {"family": "Salami", "given": "Fereshte", "initials": "F"}, {"family": "Aranda-Guill\u00e9n", "given": "Maribel", "initials": "M"}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A"}, {"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "S"}, {"family": "Zhang", "given": "Qian", "initials": "Q"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "J"}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}], "type": "journal article", "published": "2022-09-13", "journal": {"title": "J Allergy Clin Immunol", "issn": "1097-6825", "issn-l": "0091-6749", "volume": null, "issue": null, "pages": null}, "abstract": "Most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals are asymptomatic or only exhibit mild disease. In about 10% of cases, the infection leads to hypoxemic pneumonia, although it is much more rare in children.\r\n\r\nWe evaluated 31 young patients aged 0.5 to 19 years who had preexisting inborn errors of immunity (IEI) but lacked a molecular diagnosis and were later diagnosed with coronavirus disease 2019 (COVID-19) complications.\r\n\r\nGenetic evaluation by whole-exome sequencing was performed in all patients. SARS-CoV-2-specific antibodies, autoantibodies against type I IFN (IFN-I), and inflammatory factors in plasma were measured. We also reviewed COVID-19 disease severity/outcome in reported IEI patients.\r\n\r\nA potential genetic cause of the IEI was identified in 28 patients (90.3%), including mutations that may affect IFN signaling, T- and B-cell function, the inflammasome, and the complement system. From tested patients 65.5% had detectable virus-specific antibodies, and 6.8% had autoantibodies neutralizing IFN-I. Five patients (16.1%) fulfilled the diagnostic criteria of multisystem inflammatory syndrome in children. Eleven patients (35.4%) died of COVID-19 complications. All together, at least 381 IEI children with COVID-19 have been reported in the literature to date. Although many patients with asymptomatic or mild disease may not have been reported, severe presentation of COVID-19 was observed in 23.6% of the published cases, and the mortality rate was 8.7%.\r\n\r\nYoung patients with preexisting IEI may have higher mortality than children without IEI when infected with SARS-CoV-2. Elucidating the genetic basis of IEI patients with severe/critical COVID-19 may help to develop better strategies for prevention and treatment of severe COVID-19 disease and complications in pediatric patients.", "doi": "10.1016/j.jaci.2022.09.005", "pmid": "36113674", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "S0091-6749(22)01185-X"}, {"db": "pmc", "key": "PMC9472457"}], "notes": [], "created": "2022-10-13T13:32:35.129Z", "modified": "2022-10-13T13:34:58.395Z"}, {"entity": "publication", "iuid": "445377ec34e046d7a5d2375bd676828e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/445377ec34e046d7a5d2375bd676828e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/445377ec34e046d7a5d2375bd676828e"}}, "title": "COVID-19 is associated with bystander polyclonal autoreactive B cell activation as reflected by a broad autoantibody production, but none is linked to disease severity.", "authors": [{"family": "Jiang", "given": "Wei", "initials": "W", "orcid": "0000-0002-1374-053X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b3788374c8a4b83a5d94577fa1ff933.json"}}, {"family": "Johnson", "given": "Douglas", "initials": "D"}, {"family": "Adekunle", "given": "Ruth", "initials": "R"}, {"family": "Heather", "given": "Hughes", "initials": "H"}, {"family": "Xu", "given": "Wanli", "initials": "W"}, {"family": "Cong", "given": "Xiaomei", "initials": "X"}, {"family": "Wu", "given": "Xueling", "initials": "X"}, {"family": "Fan", "given": "Hongkuan", "initials": "H"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "L"}, {"family": "Robertson", "given": "Josefina", "initials": "J"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2022-09-10", "journal": {"title": "J Med Virol", "issn": "1096-9071", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Coronavirus disease 2019 (COVID-19) is associated with autoimmune features and autoantibody production in a small subset of the population. Pre-existing neutralizing antitype I interferons (IFNs) autoantibodies are related to the severity of COVID-19. Plasma levels of IgG and IgM against 12 viral antigens and 103 self-antigens were evaluated using an antibody protein array in patients with severe/critical or mild/moderate COVID-19 disease and uninfected controls. Patients exhibited increased IgGs against Severe acute respiratory syndrome coronavirus-2 proteins compared to controls, but no difference was observed in the two patient groups. 78% autoreactive IgGs and 93% autoreactive IgMs were increased in patients versus controls. There was no difference in the plasma levels of anti-type I IFN autoantibodies or neutralizing anti-type I IFN activity of plasma samples from the two patient groups. Increased anti-type I IFN IgGs were correlated with higher lymphocyte accounts, suggesting a role of nonpathogenic autoantibodies. Notably, among the 115 antibodies tested, only plasma levels of IgGs against human coronavirus (HCOV)-229E and HCOV-NL63 spike proteins were associated with mild disease outcome. COVID-19 was associated with a bystander polyclonal autoreactive B cell activation, but none of the autoantibody levels were linked to disease severity. Long-term humoral immunity against HCOV-22E and HCOV-NL63 spike protein was associated with mild disease outcome. Understanding the mechanism of life-threatening COVID-19 is critical to reducing mortality and morbidity.", "doi": "10.1002/jmv.28134", "pmid": "36086941", "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9538121"}], "notes": [], "created": "2022-10-13T13:27:53.034Z", "modified": "2022-10-13T14:41:54.606Z"}, {"entity": "publication", "iuid": "cfc18a5797b240c0920df270cb4586db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfc18a5797b240c0920df270cb4586db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfc18a5797b240c0920df270cb4586db"}}, "title": "Thrombosis with thrombocytopenia after AZD1222 (ChAdOx1 nCov-19) vaccination: Case characteristics and associations.", "authors": [{"family": "Laffan", "given": "Michael A", "initials": "MA"}, {"family": "Rees", "given": "Sue", "initials": "S"}, {"family": "Yadavalli", "given": "Madhavi", "initials": "M"}, {"family": "Ferstenberg", "given": "Lisa Beth", "initials": "LB"}, {"family": "Kumar Shankar", "given": "Nirmal", "initials": "N"}, {"family": "Medin", "given": "Jennie", "initials": "J"}, {"family": "Foskett", "given": "Nadia", "initials": "N"}, {"family": "Arnold", "given": "Matthew", "initials": "M"}, {"family": "Gomes da Silva", "given": "Hugo", "initials": "H"}, {"family": "Bhuyan", "given": "Prakash", "initials": "P"}, {"family": "Nord", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2022-09-09", "journal": {"title": "Vaccine", "issn": "1873-2518", "volume": "40", "issue": "38", "pages": "5585-5593", "issn-l": null}, "abstract": "Post-marketing surveillance for COVID-19 vaccines during the pandemic identified an extremely rare thrombosis with thrombocytopenia syndrome (TTS) reported post-vaccination, requiring further characterisation to improve diagnosis and management.\n\nWe searched the AstraZeneca Global Safety Database (through April 26, 2021) for cases with co-reported thrombocytopenia and thrombosis (using standardised MedDRA queries/high-level terms) following AZD1222 (ChAdOx1 nCoV-19). Cases were adjudicated by experts as 'typical','possible', 'no' or 'unknown' according to available TTS criteria. Additional confirmatory datasets (May 20-June 20, October 1-December 28) were evaluated.\n\nWe identified 573 reports, including 273 (47.6 %) 'typical' and 171 (29.8 %) 'possible' TTS cases. Of these 444 cases, 275 (61.9 %) were female, median age was 50.0 years (IQR: 38.0-60.0). Cerebral venous sinus thrombosis was reported in 196 (44.1 %) cases, splanchnic venous thrombosis in 65 (14.6 %) and thromboses at multiple sites in 119 (26.8 %). Median time to onset was 12.0 days (IQR: 9.0-15.0). Comparison with a pre-pandemic reference population indicated higher rates of autoimmune disorders (13.8 %, 4.4 %), previous heparin therapy (7.4 %, 1.2 %), history of thrombosis (5.5 %, 1.4 %), and immune thrombocytopenia (6.1 %, 0.2 %). Fatality rate was 22.2 % (127/573) overall and 23.6 % (105/444) in 'typical'/'possible' TTS, which decreased from 39.0 % (60/154) in February/March to 15.5 % (45/290) in April. Overall patterns were similar in confirmatory datasets.\n\nThe reporting rate of 'typical'/'possible' TTS post first-dose vaccination in this dataset is 7.5 per million vaccinated persons; few cases were reported after subsequent doses, including booster doses. Peak reporting coincided with media-driven attention. Medical history differences versus a reference population indicate potentially unidentified risk factors. The decreasing fatality rate correlates with increasing awareness and publication of diagnostic/treatment guidelines. Adjudication was hindered by unreported parameters, and an algorithm was developed to classify potential TTS cases; comprehensive reporting could help further improve definition and management of this extremely rare syndrome.", "doi": "10.1016/j.vaccine.2022.08.007", "pmid": "35989136", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(22)00964-1"}, {"db": "pmc", "key": "PMC9388294"}], "notes": [], "created": "2022-09-12T18:49:59.431Z", "modified": "2022-09-12T18:50:20.934Z"}, {"entity": "publication", "iuid": "98c4fad1a2c54587ab229be91b562c70", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/98c4fad1a2c54587ab229be91b562c70.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/98c4fad1a2c54587ab229be91b562c70"}}, "title": "Sialic Acid and Fucose Residues on the SARS-CoV-2 Receptor-Binding Domain Modulate IgG Antibody Reactivity.", "authors": [{"family": "Samuelsson", "given": "Ebba", "initials": "E"}, {"family": "Mirgorodskaya", "given": "Ekaterina", "initials": "E"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "B\u00e4ckstr\u00f6m", "given": "Malin", "initials": "M"}, {"family": "Liljeqvist", "given": "Jan-\u00c5ke", "initials": "J\u00c5"}, {"family": "Nord\u00e9n", "given": "Rickard", "initials": "R", "orcid": "0000-0002-3866-7228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/270f5cf52d6544a78dc4bde1bf1e97a2.json"}}], "type": "journal article", "published": "2022-09-09", "journal": {"title": "ACS Infect Dis", "issn": "2373-8227", "volume": "8", "issue": "9", "pages": "1883-1893", "issn-l": null}, "abstract": "The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is a conserved domain and a target for neutralizing antibodies. We defined the carbohydrate content of the recombinant RBD produced in different mammalian cells. We found a higher degree of complex-type N-linked glycans, with less sialylation and more fucosylation, when the RBD was produced in human embryonic kidney cells compared to the same protein produced in Chinese hamster ovary cells. The carbohydrates on the RBD proteins were enzymatically modulated, and the effect on antibody reactivity was evaluated with serum samples from SARS-CoV-2 positive patients. Removal of all carbohydrates diminished antibody reactivity, while removal of only sialic acids or terminal fucoses improved the reactivity. The RBD produced in Lec3.2.8.1-cells, which generate carbohydrate structures devoid of sialic acids and with reduced fucose content, exhibited enhanced antibody reactivity, verifying the importance of these specific monosaccharides. The results can be of importance for the design of future vaccine candidates, indicating that it is possible to enhance the immunogenicity of recombinant viral proteins.", "doi": "10.1021/acsinfecdis.2c00155", "pmid": "35980012", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:42:27.556Z", "modified": "2022-09-12T18:42:50.047Z"}, {"entity": "publication", "iuid": "968c86731eb34291987dde45dbc6e055", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/968c86731eb34291987dde45dbc6e055.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/968c86731eb34291987dde45dbc6e055"}}, "title": "Recovering from COVID-19 - A Process Characterised by Uncertainty: A Qualitative study.", "authors": [{"family": "Engwall", "given": "Marie", "initials": "M"}, {"family": "T\u00f6rnbom", "given": "Karin", "initials": "K"}, {"family": "Persson", "given": "Hanna C", "initials": "HC"}, {"family": "Palstam", "given": "Annie", "initials": "A"}], "type": "journal article", "published": "2022-09-09", "journal": {"title": "J Rehabil Med", "issn": "1651-2081", "volume": "54", "pages": "jrm00326", "issn-l": null}, "abstract": "To obtain a deeper understanding of the lived experiences of patients with COVID-19, the recovery process and consequences for everyday life 6 months after hospital discharge.\n\nAn explorative qualitative study using individual interviews.\n\nA purposive sampling was applied to recruit persons who had received inpatient hospital care, were discharged approximately 6 months previously, were of working age and had persistent self-reported symptoms at a 3-month follow-up appointment.\n\nSemi-structured interviews were conducted with 15 participants (10 men, 5 women), which were then transcribed and analysed with inductive thematic analysis.\n\nThree themes were identified: \"Status of recovery - two steps forward, one step back\", \"Remaining symptoms caused limitations in everyday life\" and \"Strategies for recovery\". Participants indicated the recovery process through 6 months after discharge was a challenging road, often involving setbacks. A wide range of persistent, fluctuating, or new symptoms negatively impacted many areas of daily life, with fatigue and lack of energy being especially prominent. Participants used a variety of strategies to cope and recover.\n\nThis study increases our knowledge of the lived experiences of COVID-19 based individual experiences. Unexpected symptoms in the recovery process were described and not always possible to forecast.", "doi": "10.2340/jrm.v54.2739", "pmid": "35976769", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:39:02.356Z", "modified": "2022-09-12T18:39:02.362Z"}, {"entity": "publication", "iuid": "79254181a0ab4b0ca26323a6deb65af0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79254181a0ab4b0ca26323a6deb65af0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79254181a0ab4b0ca26323a6deb65af0"}}, "title": "Monitoring of the SARS-CoV-2 Omicron BA.1/BA.2 lineage transition in the Swedish population reveals increased viral RNA levels in BA.2 cases.", "authors": [{"family": "Lentini", "given": "Antonio", "initials": "A"}, {"family": "Pereira", "given": "Antonio", "initials": "A"}, {"family": "Winqvist", "given": "Ola", "initials": "O"}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-7021-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9eef54f4e0534805b173cfae62a75d55.json"}}], "type": "case reports", "published": "2022-09-09", "journal": {"title": "Med (N Y)", "issn": "2666-6340", "issn-l": null, "volume": "3", "issue": "9", "pages": "636-643.e4"}, "abstract": "Throughout the SARS-CoV-2 pandemic, multiple waves of variants of concern have swept across populations, leading to a chain of new and yet more contagious variants dominating COVID-19 cases. Here, we tracked the remarkably rapid shift from Omicron BA.1 to BA.2 sublineage dominance in the Swedish population in early 2022 at a day-by-day basis.\n\nUsing a custom SARS-CoV-2 Omicron BA.1 lineage-typing RT-PCR assay, we analyzed 174,933 clinical upper airway samples collected during January to March 2022.\n\nOur study demonstrates the feasibility and reliability of parallel lineage assignment of select variants at population scale, tracking the dominant sublineage transition from BA.1 to BA.2 at day-to-day resolution and uncovering nearly 2-fold higher levels of viral RNA in cases infected with Omicron BA.2 relative to BA.1.\n\nOur data provide unique insights into the Omicron BA.1 to BA.2 transition that occurred in Sweden during early 2022, and later, across the world. This may help to understand the increased transmissibility of the BA.2 variant.", "doi": "10.1016/j.medj.2022.07.007", "pmid": "35981541", "labels": {"Category: Health": null, "Category: Omicron VoC": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9359497"}, {"db": "pii", "key": "S2666-6340(22)00317-8"}], "notes": [], "created": "2022-03-28T10:31:50.830Z", "modified": "2023-06-19T15:01:12.299Z"}, {"entity": "publication", "iuid": "c73f45508d7b4fb995f7ceccefa7a93d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c73f45508d7b4fb995f7ceccefa7a93d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c73f45508d7b4fb995f7ceccefa7a93d"}}, "title": "Back to life: Is it possible to be myself again? A qualitative study with persons initially hospitalised due to COVID-19.", "authors": [{"family": "T\u00f6rnbom", "given": "Karin", "initials": "K"}, {"family": "Engwall", "given": "Marie", "initials": "M"}, {"family": "Persson", "given": "Hanna C", "initials": "HC"}, {"family": "Palstam", "given": "Annie", "initials": "A"}], "type": "journal article", "published": "2022-09-09", "journal": {"title": "J Rehabil Med", "issn": "1651-2081", "volume": "54", "pages": "jrm00327", "issn-l": null}, "abstract": "To gain a deeper understanding of the lived experiences of patients with COVID-19, regarding rehabilitation, work and social life 6 months after hospital discharge.\n\nAn explorative qualitative study with individual interviews.\n\nPatients of working age with persistent self-reported symptoms at a 3-month follow-up who had received inpatient hospital care with discharge approximately 6 months previously were purposively sampled.\n\nSemi-structured interviews were performed with 10 men and 5 women. The interviews were transcribed verbatim and analysed with inductive thematic analysis.\n\nFour themes were identified: \"Social support - crucial, but decreased over time\", \"Varying needs of, and access to, rehabilitation\", \"Returning to work after COVID-19 - crucial for future prospects\" and \"An overwhelming experience that essentially changed one's personality\".\n\nRehabilitation provided participants with the valuable tools for recovery, giving them hope for future recovery. Support from next of kin was highly valued, creating stronger family bonds. A new meaning and greater appreciation of life was expressed.", "doi": "10.2340/jrm.v54.2742", "pmid": "35976766", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:38:30.988Z", "modified": "2022-09-12T18:38:30.993Z"}, {"entity": "publication", "iuid": "3468fd2046304320ab7fc4fbe3c66355", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3468fd2046304320ab7fc4fbe3c66355.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3468fd2046304320ab7fc4fbe3c66355"}}, "title": "Spatio-temporal predictions of COVID-19 test positivity in Uppsala County, Sweden: a comparative approach.", "authors": [{"family": "van Zoest", "given": "Vera", "initials": "V", "orcid": "0000-0002-3017-0874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72aee535dc8c45478a4cf678e01d2421.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G"}, {"family": "Menzel", "given": "Uwe", "initials": "U"}, {"family": "Wigren", "given": "Anders", "initials": "A"}, {"family": "Kennedy", "given": "Beatrice", "initials": "B", "orcid": "0000-0002-0066-4814", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d3a346caa424c4dad653097b2518efb.json"}}, {"family": "Martinell", "given": "Mats", "initials": "M"}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f34c0d3602439abe6096293c7c732d.json"}}], "type": "journal article", "published": "2022-09-07", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "15176", "issn-l": "2045-2322"}, "abstract": "Previous spatio-temporal COVID-19 prediction models have focused on the prediction of subsequent number of cases, and have shown varying accuracy and lack of high geographical resolution. We aimed to predict trends in COVID-19 test positivity, an important marker for planning local testing capacity and accessibility. We included a full year of information (June 29, 2020-July 4, 2021) with both direct and indirect indicators of transmission, e.g. mobility data, number of calls to the national healthcare advice line and vaccination coverage from Uppsala County, Sweden, as potential predictors. We developed four models for a 1-week-window, based on gradient boosting (GB), random forest (RF), autoregressive integrated moving average (ARIMA) and integrated nested laplace approximations (INLA). Three of the models (GB, RF and INLA) outperformed the na\u00efve baseline model after data from a full pandemic wave became available and demonstrated moderate accuracy. An ensemble model of these three models slightly improved the average root mean square error to 0.039 compared to 0.040 for GB, RF and INLA, 0.055 for ARIMA and 0.046 for the na\u00efve model. Our findings indicate that the collection of a wide variety of data can contribute to spatio-temporal predictions of COVID-19 test positivity.", "doi": "10.1038/s41598-022-19155-y", "pmid": "36071066", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-19155-y"}, {"db": "pmc", "key": "PMC9450842"}], "notes": [], "created": "2022-10-13T13:26:00.407Z", "modified": "2022-10-13T13:26:21.845Z"}, {"entity": "publication", "iuid": "7e7de2c58ea7451fa5926a0741e07232", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e7de2c58ea7451fa5926a0741e07232.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e7de2c58ea7451fa5926a0741e07232"}}, "title": "Protection against SARS-CoV-2 transmission by a parenteral prime-Intranasal boost vaccine strategy.", "authors": [{"family": "Christensen", "given": "Dennis", "initials": "D"}, {"family": "Polacek", "given": "Charlotta", "initials": "C"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Moliner-Morro", "given": "Ainhoa", "initials": "A"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Hartmann", "given": "Katrine Top", "initials": "KT"}, {"family": "Jensen", "given": "Henrik Elvang", "initials": "HE"}, {"family": "Jungersen", "given": "Gregers", "initials": "G"}, {"family": "Illigen", "given": "Kristin", "initials": "K"}, {"family": "Isling", "given": "Louise Krag", "initials": "LK"}, {"family": "Jensen", "given": "Rune Fledelius", "initials": "RF"}, {"family": "Hansen", "given": "Julia Sid", "initials": "JS"}, {"family": "Rosenkrands", "given": "Ida", "initials": "I"}, {"family": "Fernandez-Antunez", "given": "Carlota", "initials": "C"}, {"family": "Ramirez", "given": "Santseharay", "initials": "S"}, {"family": "Follmann", "given": "Frank", "initials": "F"}, {"family": "Bukh", "given": "Jens", "initials": "J"}, {"family": "Pedersen", "given": "Gabriel Kristian", "initials": "GK"}], "type": "journal article", "published": "2022-09-05", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": null, "issue": null, "pages": "104248"}, "abstract": "Licensed vaccines against SARS-CoV-2 effectively protect against severe disease, but display incomplete protection against virus transmission. Mucosal vaccines providing immune responses in the upper airways are one strategy to protect against transmission.\r\n\r\nWe administered Spike HexaPro trimer formulated in a cationic liposomal adjuvant as a parenteral (subcutaneous - s.c.) prime - intranasal boost regimen to elicit airway mucosal immune responses and evaluated this in a Syrian hamster model of virus transmission.\r\n\r\nParenteral prime - intranasal boost elicited high-magnitude serum neutralizing antibody responses and IgA responses in the upper respiratory tract. The vaccine strategy protected against virus in the lower airways and lung pathology, but virus could still be detected in the upper airways. Despite this, the parenteral prime - intranasal booster vaccine effectively protected against onward SARS-CoV-2 transmission.\r\n\r\nThis study suggests that parenteral-prime mucosal boost is an effective strategy for protecting against SARS-CoV-2 infection and highlights that protection against virus transmission may be obtained despite incomplete clearance of virus from the upper respiratory tract. It should be noted that protection against onward transmission was not compared to standard parenteral prime-boost, which should be a focus for future studies.\r\n\r\nThis work was primarily supported by the European Union Horizon 2020 research and innovation program under grant agreement no. 101003653.", "doi": "10.1016/j.ebiom.2022.104248", "pmid": "36088218", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "S2352-3964(22)00430-3"}], "notes": [], "created": "2022-09-12T19:32:33.868Z", "modified": "2022-09-12T19:33:52.615Z"}, {"entity": "publication", "iuid": "d20e1200b5a14722a7cf1ef691ea52dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d20e1200b5a14722a7cf1ef691ea52dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d20e1200b5a14722a7cf1ef691ea52dd"}}, "title": "Cross-direct effects in settings with two mediators.", "authors": [{"family": "Gabriel", "given": "Erin E", "initials": "EE", "orcid": "0000-0002-0504-8404", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a390da0ea8a54bf6a7eec1aec5959ba2.json"}}, {"family": "Sj\u00f6lander", "given": "Arvid", "initials": "A", "orcid": "0000-0001-5226-6685", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9de77f267804d99b19c0e47237cf413.json"}}, {"family": "Follmann", "given": "Dean", "initials": "D"}, {"family": "Sachs", "given": "Michael C", "initials": "MC", "orcid": "0000-0002-1279-8676", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e1b0576ba84040bb393a4ecee4cb3b.json"}}], "type": "journal article", "published": "2022-09-02", "journal": {"title": "Biostatistics", "issn": "1468-4357", "issn-l": null}, "abstract": "When multiple mediators are present, there are additional effects that may be of interest beyond the well-known natural (NDE) and controlled direct effects (CDE). These effects cross the type of control on the mediators, setting one to a constant level and one to its natural level, which differs across subjects. We introduce five such estimands for the cross-CDE and -NDE when two mediators are measured. We consider both the scenario where one mediator is influenced by the other, referred to as sequential mediators, and the scenario where the mediators do not influence each other. Such estimands may be of interest in immunology, as we discuss in relation to measured immunological responses to SARS-CoV-2 vaccination. We provide identifying expressions for the estimands in observational settings where there is no residual confounding, and where intervention, outcome, and mediators are of arbitrary type. We further provide tight symbolic bounds for the estimands in randomized settings where there may be residual confounding of the outcome and mediator relationship and all measured variables are binary.", "doi": "10.1093/biostatistics/kxac037", "pmid": "36050911", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6684013"}], "notes": [], "created": "2022-10-13T13:18:27.085Z", "modified": "2022-10-13T13:18:52.493Z"}, {"entity": "publication", "iuid": "c43434d2bca64fc8af96906e2c5fbccf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c43434d2bca64fc8af96906e2c5fbccf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c43434d2bca64fc8af96906e2c5fbccf"}}, "title": "\"Role of kidney function and concentrations of BAFF, sPD-L1 and sCD25 on mortality in hospitalized patients with COVID-19\".", "authors": [{"family": "Mansouri", "given": "Ladan", "initials": "L"}, {"family": "Sendic", "given": "Senka", "initials": "S"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Jacobson", "given": "Stefan H", "initials": "SH"}, {"family": "Lundahl", "given": "Joachim", "initials": "J"}], "type": "journal article", "published": "2022-09-02", "journal": {"title": "BMC Nephrol", "issn": "1471-2369", "volume": "23", "issue": "1", "pages": "299", "issn-l": null}, "abstract": "Chronic kidney disease (CKD) is a recognized risk factor for severe complications in COVID-19. Our objective was to analyze the association between kidney function / T and B lymphocyte modulatory factors and risk of mortality in COVID-19 patients.\n\nIn-hospital and 30-day mortality were analyzed in COVID-19 patients (n = 110). Plasma levels of selected T and B cell modulators were analyzed and correlated to mortality risk. A subgroup of sex- and eGFR-matched COVID-19 patients was compared to CKD patients without infection and healthy subjects.\n\nCOVID-19 patients who died in hospital and within 30 days had significantly higher BAFF and sCD25 plasma levels than survivors. In logistic regression models patients with high BAFF, sCD25 and sPD-L1 levels had significantly higher risk of both in-hospital and 30-day mortality while there was no association to eGFR. In the subgroup analysis, a higher level of BAFF, IFN-\u03b1, sCD25, sPD-L1 and a lower level of sCD40L was observed in COVID-19 patients compared to the CKD group with corresponding kidney function.\n\nWe demonstrate that kidney function and concentrations of BAFF, sCD25 and PD-L1, independent of previously recognized risk factors; age, male gender, and leukocytosis are associated with risk of in-hospital and 30-day mortality in patients with COVID-19. These data indicate the significance of adaptive immune system modulators in COVID-19 and motivate further analysis to identify new potential prognostic and therapeutic approaches.", "doi": "10.1186/s12882-022-02924-2", "pmid": "36056305", "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12882-022-02924-2"}, {"db": "pmc", "key": "PMC9438228"}], "notes": [], "created": "2022-10-13T13:22:06.214Z", "modified": "2022-10-13T13:22:06.226Z"}, {"entity": "publication", "iuid": "023f130b0f164fcfb08ed1472c1bee2d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/023f130b0f164fcfb08ed1472c1bee2d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/023f130b0f164fcfb08ed1472c1bee2d"}}, "title": "International Perspectives on the Impact of the COVID-19 Pandemic on Adherence to Prescribed Dual Antiplatelet Therapy: A Window Into Acute Cardiovascular Care.", "authors": [{"family": "Pollack", "given": "Charles V", "initials": "CV"}, {"family": "Steg", "given": "P Gabriel", "initials": "PG"}, {"family": "James", "given": "Stefan", "initials": "S"}, {"family": "Jolly", "given": "Sanjit", "initials": "S"}, {"family": "Kosiborod", "given": "Mikhail", "initials": "M"}, {"family": "Bonaca", "given": "Marc P", "initials": "MP"}], "type": "journal article", "published": "2022-09-01", "journal": {"title": "Crit Pathw Cardiol", "issn": "1535-2811", "volume": "21", "issue": "3", "pages": "114-122", "issn-l": null}, "abstract": "An international panel of expert clinicians and researchers in acute cardiac care was convened to review, describe, and contextualize their varied experiences delivering care and maintaining ongoing research during the first year of the COVID-19 pandemic and beyond. A proposed perspective from which care and outcomes could be viewed was the possibility that without routine follow-up and as-accustomed interactions with their care team, patients at risk of acute atherothrombotic events might be less adherent to prescribed antiplatelet medications. This might be manifested by more emergency coronary events or by an increased (and perhaps unidentifiable) incidence of out-of-hospital cardiovascular deaths related to patient anxiety about presenting to hospital during the pandemic. The experiences of the panel members were similar in many regards, which identified opportunities for improvement in cardiac care the next time there is a substantial disruption of usual practice. Regardless of geography or payor system, there was an identified need for better remote care platforms; but stronger infrastructure and consumer facility with remote care technology, improved provider-patient communication to help ensure adherence to primary and secondary prevention medications, and longer-term prescription fills and no-hassle refills on such medications. Profound disruptions in acute cardiovascular research highlighted the need for redundancy or back-up planning for teams engaged in time-sensitive research, to ensure both continuity of protocols and patient safety.", "doi": "10.1097/HPC.0000000000000292", "pmid": "35994719", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00132577-202209000-00002"}, {"db": "pmc", "key": "PMC9389943"}], "notes": [], "created": "2022-09-12T19:00:10.930Z", "modified": "2022-09-12T19:00:21.855Z"}, {"entity": "publication", "iuid": "1863b4966cc3452b824b91225a55eed6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1863b4966cc3452b824b91225a55eed6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1863b4966cc3452b824b91225a55eed6"}}, "title": "High-dimensional multinomial multiclass severity scoring of COVID-19 pneumonia using CT radiomics features and machine learning algorithms.", "authors": [{"family": "Shiri", "given": "Isaac", "initials": "I"}, {"family": "Mostafaei", "given": "Shayan", "initials": "S"}, {"family": "Haddadi Avval", "given": "Atlas", "initials": "A"}, {"family": "Salimi", "given": "Yazdan", "initials": "Y"}, {"family": "Sanaat", "given": "Amirhossein", "initials": "A"}, {"family": "Akhavanallaf", "given": "Azadeh", "initials": "A"}, {"family": "Arabi", "given": "Hossein", "initials": "H"}, {"family": "Rahmim", "given": "Arman", "initials": "A"}, {"family": "Zaidi", "given": "Habib", "initials": "H"}], "type": "journal article", "published": "2022-09-01", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "14817", "issn-l": "2045-2322"}, "abstract": "We aimed to construct a prediction model based on computed tomography (CT) radiomics features to classify COVID-19 patients into severe-, moderate-, mild-, and non-pneumonic. A total of 1110 patients were studied from a publicly available dataset with 4-class severity scoring performed by a radiologist (based on CT images and clinical features). The entire lungs were segmented and followed by resizing, bin discretization and radiomic features extraction. We utilized two feature selection algorithms, namely bagging random forest (BRF) and multivariate adaptive regression splines (MARS), each coupled to a classifier, namely multinomial logistic regression (MLR), to construct multiclass classification models. The dataset was divided into 50% (555 samples), 20% (223 samples), and 30% (332 samples) for training, validation, and untouched test datasets, respectively. Subsequently, nested cross-validation was performed on train/validation to select the features and tune the models. All predictive power indices were reported based on the testing set. The performance of multi-class models was assessed using precision, recall, F1-score, and accuracy based on the 4 \u00d7 4 confusion matrices. In addition, the areas under the receiver operating characteristic curves (AUCs) for multi-class classifications were calculated and compared for both models. Using BRF, 23 radiomic features were selected, 11 from first-order, 9 from GLCM, 1 GLRLM, 1 from GLDM, and 1 from shape. Ten features were selected using the MARS algorithm, namely 3 from first-order, 1 from GLDM, 1 from GLRLM, 1 from GLSZM, 1 from shape, and 3 from GLCM features. The mean absolute deviation, skewness, and variance from first-order and flatness from shape, and cluster prominence from GLCM features and Gray Level Non Uniformity Normalize from GLRLM were selected by both BRF and MARS algorithms. All selected features by BRF or MARS were significantly associated with four-class outcomes as assessed within MLR (All p values < 0.05). BRF + MLR and MARS + MLR resulted in pseudo-R2 prediction performances of 0.305 and 0.253, respectively. Meanwhile, there was a significant difference between the feature selection models when using a likelihood ratio test (p value = 0.046). Based on confusion matrices for BRF + MLR and MARS + MLR algorithms, the precision was 0.856 and 0.728, the recall was 0.852 and 0.722, whereas the accuracy was 0.921 and 0.861, respectively. AUCs (95% CI) for multi-class classification were 0.846 (0.805-0.887) and 0.807 (0.752-0.861) for BRF + MLR and MARS + MLR algorithms, respectively. Our models based on the utilization of radiomic features, coupled with machine learning were able to accurately classify patients according to the severity of pneumonia, thus highlighting the potential of this emerging paradigm in the prognostication and management of COVID-19 patients.", "doi": "10.1038/s41598-022-18994-z", "pmid": "36050434", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-18994-z"}, {"db": "pmc", "key": "PMC9437017"}], "notes": [], "created": "2022-10-13T13:07:03.780Z", "modified": "2022-10-13T13:07:03.796Z"}, {"entity": "publication", "iuid": "86c2b35ac05c4a20a212e1670b3e12c4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86c2b35ac05c4a20a212e1670b3e12c4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86c2b35ac05c4a20a212e1670b3e12c4"}}, "title": "Decreased renal perfusion during acute kidney injury in critical COVID-19 assessed by magnetic resonance imaging: a prospective case control study.", "authors": [{"family": "Luther", "given": "Tomas", "initials": "T"}, {"family": "Eckerbom", "given": "Per", "initials": "P"}, {"family": "Cox", "given": "Eleanor", "initials": "E"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "B\u00fclow", "given": "Sara", "initials": "S"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Torrente", "given": "Francisco Martinez", "initials": "FM"}, {"family": "Weis", "given": "Jan", "initials": "J"}, {"family": "Palm", "given": "Fredrik", "initials": "F"}, {"family": "Francis", "given": "Susan", "initials": "S"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Liss", "given": "Per", "initials": "P"}], "type": "clinical trial", "published": "2022-09-01", "journal": {"title": "Crit Care", "issn": "1466-609X", "issn-l": "1364-8535", "volume": "26", "issue": "1", "pages": "262"}, "abstract": "Renal hypoperfusion has been suggested to contribute to the development of acute kidney injury (AKI) in critical COVID-19. However, limited data exist to support this. We aim to investigate the differences in renal perfusion, oxygenation and water diffusion using multiparametric magnetic resonance imaging in critically ill COVID-19 patients with and without AKI.\r\n\r\nA prospective case-control study where patients without prior kidney disease treated in intensive care for respiratory failure due to COVID-19 were examined. Kidney Disease: Improving Global Outcomes Creatinine criteria were used for group allocation. Main comparisons were tested using Mann-Whitney U test.\r\n\r\nNineteen patients were examined, ten with AKI and nine without AKI. Patients with AKI were examined in median 1 [0-2] day after criteria fulfillment. Age and baseline Plasma-Creatinine were similar in both groups. Total renal blood flow was lower in patients with AKI compared with patients without (median 645 quartile range [423-753] vs. 859 [746-920] ml/min, p = 0.037). Regional perfusion was reduced in both cortex (76 [51-112] vs. 146 [123-169] ml/100 g/min, p = 0.015) and medulla (28 [18-47] vs. 47 [38-73] ml/100 g/min, p = 0.03). Renal venous saturation was similar in both groups (72% [64-75] vs. 72% [63-84], ns.), as was regional oxygenation (R2*) in cortex (17 [16-19] vs. 17 [16-18] 1/s, ns.) and medulla (29 [24-39] vs. 27 [23-29] 1/s, ns.).\r\n\r\nIn critically ill COVID-19 patients with AKI, the total, cortical and medullary renal blood flows were reduced compared with similar patients without AKI, whereas no differences in renal oxygenation were demonstrable in this setting. Trial registration ClinicalTrials ID: NCT02765191 , registered May 6 2014 and updated May 7 2020.", "doi": "10.1186/s13054-022-04132-8", "pmid": "36050748", "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: VR": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-022-04132-8"}, {"db": "pmc", "key": "PMC9434518"}, {"db": "ClinicalTrials.gov", "key": "NCT02765191"}], "notes": [], "created": "2022-10-13T13:09:07.211Z", "modified": "2022-10-13T13:12:09.772Z"}, {"entity": "publication", "iuid": "cd676674860e43b297b2ffd3e77406b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd676674860e43b297b2ffd3e77406b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd676674860e43b297b2ffd3e77406b0"}}, "title": "When ethnographic work turns into distant screen visits: A note on flexible inflexibility during the COVID-19 pandemic.", "authors": [{"family": "Sandberg", "given": "Helena", "initials": "H"}, {"family": "Sundin", "given": "Ebba", "initials": "E", "orcid": "0000-0001-8712-7159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/55da76954579410d8b8c795429f03149.json"}}, {"family": "Sj\u00f6berg", "given": "Ulrika", "initials": "U"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Contemp Issues Early Child", "issn": "1463-9491", "issn-l": null, "volume": "23", "issue": "3", "pages": "361-365"}, "abstract": "This colloquium shares experiences from doing ethnographic fieldwork with young children and the challenges that followed due to the COVID-19 pandemic. The project DIGIKIDS Sweden has its focus on very young children (birth to three years) and their engagement with digital media technologies in their homes. The pandemic put the project on hold, but in the families where the fieldwork had already started, the authors decided to change the methods of data collection. Digital screen visits were introduced and, at first, this seemed to be flexible, and they adjusted to the new environment. At the same time, this flexibility also became an inflexible experience due to the use of technology.", "doi": "10.1177/14639491221107361", "pmid": "37520115", "labels": {"Funder: VR": null, "Category: Other": null, "Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC9194497"}, {"db": "pii", "key": "10.1177_14639491221107361"}], "notes": [], "created": "2023-10-04T12:12:41.646Z", "modified": "2023-10-04T13:32:54.390Z"}, {"entity": "publication", "iuid": "70ac7e22db0848d588ed605cd740756d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70ac7e22db0848d588ed605cd740756d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70ac7e22db0848d588ed605cd740756d"}}, "title": "The effect of different degrees of lockdown and self-identified gender on anxiety, depression and suicidality during the COVID-19 pandemic: Data from the international COMET-G study.", "authors": [{"family": "Fountoulakis", "given": "Konstantinos N", "initials": "KN"}, {"family": "Karakatsoulis", "given": "Grigorios N", "initials": "GN"}, {"family": "Abraham", "given": "Seri", "initials": "S"}, {"family": "Adorjan", "given": "Kristina", "initials": "K"}, {"family": "Ahmed", "given": "Helal Uddin", "initials": "HU"}, {"family": "Alarc\u00f3n", "given": "Renato D", "initials": "RD"}, {"family": "Arai", "given": "Kiyomi", "initials": "K"}, {"family": "Auwal", "given": "Sani Salihu", "initials": "SS"}, {"family": "Berk", "given": "Michael", "initials": "M"}, {"family": "Bjedov", "given": "Sarah", "initials": "S"}, {"family": "Bobes", "given": "Julio", "initials": "J"}, {"family": "Bobes-Bascaran", "given": "Teresa", "initials": "T"}, {"family": "Bourgin-Duchesnay", "given": "Julie", "initials": "J"}, {"family": "Bredicean", "given": "Cristina Ana", "initials": "CA"}, {"family": "Bukelskis", "given": "Laurynas", "initials": "L"}, {"family": "Burkadze", "given": "Akaki", "initials": "A"}, {"family": "Abud", "given": "Indira Indiana Cabrera", "initials": "IIC"}, {"family": "Castilla-Puentes", "given": "Ruby", "initials": "R"}, {"family": "Cetkovich", "given": "Marcelo", "initials": "M"}, {"family": "Colon-Rivera", "given": "Hector", "initials": "H"}, {"family": "Corral", "given": "Ricardo", "initials": "R"}, {"family": "Cortez-Vergara", "given": "Carla", "initials": "C"}, {"family": "Crepin", "given": "Piirika", "initials": "P"}, {"family": "De Berardis", "given": "Domenico", "initials": "D"}, {"family": "Delgado", "given": "Sergio Zamora", "initials": "SZ"}, {"family": "De Lucena", "given": "David", "initials": "D"}, {"family": "De Sousa", "given": "Avinash", "initials": "A"}, {"family": "Stefano", "given": "Ramona Di", "initials": "RD"}, {"family": "Dodd", "given": "Seetal", "initials": "S"}, {"family": "Elek", "given": "Livia Priyanka", "initials": "LP"}, {"family": "Elissa", "given": "Anna", "initials": "A"}, {"family": "Erdelyi-Hamza", "given": "Berta", "initials": "B"}, {"family": "Erzin", "given": "Gamze", "initials": "G"}, {"family": "Etchevers", "given": "Martin J", "initials": "MJ"}, {"family": "Falkai", "given": "Peter", "initials": "P"}, {"family": "Farcas", "given": "Adriana", "initials": "A"}, {"family": "Fedotov", "given": "Ilya", "initials": "I"}, {"family": "Filatova", "given": "Viktoriia", "initials": "V"}, {"family": "Fountoulakis", "given": "Nikolaos K", "initials": "NK"}, {"family": "Frankova", "given": "Iryna", "initials": "I"}, {"family": "Franza", "given": "Francesco", "initials": "F"}, {"family": "Frias", "given": "Pedro", "initials": "P"}, {"family": "Galako", "given": "Tatiana", "initials": "T"}, {"family": "Garay", "given": "Cristian J", "initials": "CJ"}, {"family": "Garcia-\u00c1lvarez", "given": "Leticia", "initials": "L"}, {"family": "Garc\u00eda-Portilla", "given": "Maria Paz", "initials": "MP"}, {"family": "Gonda", "given": "Xenia", "initials": "X"}, {"family": "Gondek", "given": "Tomasz M", "initials": "TM"}, {"family": "Gonz\u00e1lez", "given": "Daniela Morera", "initials": "DM"}, {"family": "Gould", "given": "Hilary", "initials": "H"}, {"family": "Grandinetti", "given": "Paolo", "initials": "P"}, {"family": "Grau", "given": "Arturo", "initials": "A"}, {"family": "Groudeva", "given": "Violeta", "initials": "V"}, {"family": "Hagin", "given": "Michal", "initials": "M"}, {"family": "Harada", "given": "Takayuki", "initials": "T"}, {"family": "Hasan", "given": "Tasdik M", "initials": "TM"}, {"family": "Hashim", "given": "Nurul Azreen", "initials": "NA"}, {"family": "Hilbig", "given": "Jan", "initials": "J"}, {"family": "Hossain", "given": "Sahadat", "initials": "S"}, {"family": "Iakimova", "given": "Rossitza", "initials": "R"}, {"family": "Ibrahim", "given": "Mona", "initials": "M"}, {"family": "Iftene", "given": "Felicia", "initials": "F"}, {"family": "Ignatenko", "given": "Yulia", "initials": "Y"}, {"family": "Irarrazaval", "given": "Matias", "initials": "M"}, {"family": "Ismail", "given": "Zaliha", "initials": "Z"}, {"family": "Ismayilova", "given": "Jamila", "initials": "J"}, {"family": "Jacobs", "given": "Asaf", "initials": "A"}, {"family": "Jakovljevi\u0107", "given": "Miro", "initials": "M"}, {"family": "Jak\u0161i\u0107", "given": "Nenad", "initials": "N"}, {"family": "Javed", "given": "Afzal", "initials": "A"}, {"family": "Kafali", "given": "Helin Yilmaz", "initials": "HY"}, {"family": "Karia", "given": "Sagar", "initials": "S"}, {"family": "Kazakova", "given": "Olga", "initials": "O"}, {"family": "Khalifa", "given": "Doaa", "initials": "D"}, {"family": "Khaustova", "given": "Olena", "initials": "O"}, {"family": "Koh", "given": "Steve", "initials": "S"}, {"family": "Kopishinskaia", "given": "Svetlana", "initials": "S"}, {"family": "Kosenko", "given": "Korneliia", "initials": "K"}, {"family": "Koupidis", "given": "Sotirios A", "initials": "SA"}, {"family": "Kovacs", "given": "Illes", "initials": "I"}, {"family": "Kulig", "given": "Barbara", "initials": "B"}, {"family": "Lalljee", "given": "Alisha", "initials": "A"}, {"family": "Liewig", "given": "Justine", "initials": "J"}, {"family": "Majid", "given": "Abdul", "initials": "A"}, {"family": "Malashonkova", "given": "Evgeniia", "initials": "E"}, {"family": "Malik", "given": "Khamelia", "initials": "K"}, {"family": "Malik", "given": "Najma Iqbal", "initials": "NI"}, {"family": "Mammadzada", "given": "Gulay", "initials": "G"}, {"family": "Mandalia", "given": "Bilvesh", "initials": "B"}, {"family": "Marazziti", "given": "Donatella", "initials": "D"}, {"family": "Mar\u010dinko", "given": "Darko", "initials": "D"}, {"family": "Martinez", "given": "Stephanie", "initials": "S"}, {"family": "Matiekus", "given": "Eimantas", "initials": "E"}, {"family": "Mejia", "given": "Gabriela", "initials": "G"}, {"family": "Memon", "given": "Roha Saeed", "initials": "RS"}, {"family": "Mart\u00ednez", "given": "Xarah Elenne Meza", "initials": "XEM"}, {"family": "Mickevi\u010di\u016bt\u0117", "given": "Dalia", "initials": "D"}, {"family": "Milev", "given": "Roumen", "initials": "R"}, {"family": "Mohammed", "given": "Muftau", "initials": "M"}, {"family": "Molina-L\u00f3pez", "given": "Alejandro", "initials": "A"}, {"family": "Morozov", "given": "Petr", "initials": "P"}, {"family": "Muhammad", "given": "Nuru Suleiman", "initials": "NS"}, {"family": "Musta\u010d", "given": "Filip", "initials": "F"}, {"family": "Naor", "given": "Mika S", "initials": "MS"}, {"family": "Nassieb", "given": "Amira", "initials": "A"}, {"family": "Navickas", "given": "Alvydas", "initials": "A"}, {"family": "Okasha", "given": "Tarek", "initials": "T"}, {"family": "Pandova", "given": "Milena", "initials": "M"}, {"family": "Panfil", "given": "Anca-Livia", "initials": "AL"}, {"family": "Panteleeva", "given": "Liliya", "initials": "L"}, {"family": "Papava", "given": "Ion", "initials": "I"}, {"family": "Patsali", "given": "Mikaella E", "initials": "ME"}, {"family": "Pavlichenko", "given": "Alexey", "initials": "A"}, {"family": "Pejuskovic", "given": "Bojana", "initials": "B"}, {"family": "Da Costa", "given": "Mariana Pinto", "initials": "MP"}, {"family": "Popkov", "given": "Mikhail", "initials": "M"}, {"family": "Popovic", "given": "Dina", "initials": "D"}, {"family": "Raduan", "given": "Nor Jannah Nasution", "initials": "NJN"}, {"family": "Ram\u00edrez", "given": "Francisca Vargas", "initials": "FV"}, {"family": "Rancans", "given": "Elmars", "initials": "E"}, {"family": "Razali", "given": "Salmi", "initials": "S"}, {"family": "Rebok", "given": "Federico", "initials": "F"}, {"family": "Rewekant", "given": "Anna", "initials": "A"}, {"family": "Flores", "given": "Elena Ninoska Reyes", "initials": "ENR"}, {"family": "Rivera-Encinas", "given": "Mar\u00eda Teresa", "initials": "MT"}, {"family": "Saiz", "given": "Pilar", "initials": "P"}, {"family": "de Carmona", "given": "Manuel S\u00e1nchez", "initials": "MS"}, {"family": "Mart\u00ednez", "given": "David Saucedo", "initials": "DS"}, {"family": "Saw", "given": "Jo Anne", "initials": "JA"}, {"family": "Saygili", "given": "G\u00f6rkem", "initials": "G"}, {"family": "Schneidereit", "given": "Patricia", "initials": "P"}, {"family": "Shah", "given": "Bhumika", "initials": "B"}, {"family": "Shirasaka", "given": "Tomohiro", "initials": "T"}, {"family": "Silagadze", "given": "Ketevan", "initials": "K"}, {"family": "Sitanggang", "given": "Satti", "initials": "S"}, {"family": "Skugarevsky", "given": "Oleg", "initials": "O"}, {"family": "Spikina", "given": "Anna", "initials": "A"}, {"family": "Mahalingappa", "given": "Sridevi Sira", "initials": "SS"}, {"family": "Stoyanova", "given": "Maria", "initials": "M"}, {"family": "Szczegielniak", "given": "Anna", "initials": "A"}, {"family": "Tamasan", "given": "Simona Claudia", "initials": "SC"}, {"family": "Tavormina", "given": "Giuseppe", "initials": "G"}, {"family": "Tavormina", "given": "Maurilio Giuseppe Maria", "initials": "MGM"}, {"family": "Theodorakis", "given": "Pavlos N", "initials": "PN"}, {"family": "Tohen", "given": "Mauricio", "initials": "M"}, {"family": "Tsapakis", "given": "Eva Maria", "initials": "EM"}, {"family": "Tukhvatullina", "given": "Dina", "initials": "D"}, {"family": "Ullah", "given": "Irfan", "initials": "I"}, {"family": "Vaidya", "given": "Ratnaraj", "initials": "R"}, {"family": "Vega-Dienstmaier", "given": "Johann M", "initials": "JM"}, {"family": "Vrublevska", "given": "Jelena", "initials": "J"}, {"family": "Vukovic", "given": "Olivera", "initials": "O"}, {"family": "Vysotska", "given": "Olga", "initials": "O"}, {"family": "Widiasih", "given": "Natalia", "initials": "N"}, {"family": "Yashikhina", "given": "Anna", "initials": "A"}, {"family": "Prezerakos", "given": "Panagiotis E", "initials": "PE"}, {"family": "Smirnova", "given": "Daria", "initials": "D"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "volume": "315", "pages": "114702", "issn-l": null}, "abstract": "During the COVID-19 pandemic various degrees of lockdown were applied by countries around the world. It is considered that such measures have an adverse effect on mental health but the relationship of measure intensity with the mental health effect has not been thoroughly studied. Here we report data from the larger COMET-G study pertaining to this question.\n\nDuring the COVID-19 pandemic, data were gathered with an online questionnaire from 55,589 participants from 40 countries (64.85% females aged 35.80 \u00b1 13.61; 34.05% males aged 34.90\u00b113.29 and 1.10% other aged 31.64\u00b113.15). Anxiety was measured with the STAI, depression with the CES-D and suicidality with the RASS. Distress and probable depression were identified with the use of a previously developed cut-off and algorithm respectively.\n\nIt included the calculation of Relative Risk (RR), Factorial ANOVA and Multiple backwards stepwise linear regression analysis RESULTS: Approximately two-thirds were currently living under significant restrictions due to lockdown. For both males and females the risk to develop clinical depression correlated significantly with each and every level of increasing lockdown degree (RR 1.72 and 1.90 respectively). The combined lockdown and psychiatric history increased RR to 6.88 The overall relationship of lockdown with severity of depression, though significant was small.\n\nThe current study is the first which reports an almost linear relationship between lockdown degree and effect in mental health. Our findings, support previous suggestions concerning the need for a proactive targeted intervention to protect mental health more specifically in vulnerable groups.", "doi": "10.1016/j.psychres.2022.114702", "pmid": "35839639", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(22)00298-0"}, {"db": "pmc", "key": "PMC9247180"}], "notes": [], "created": "2022-08-12T08:55:50.569Z", "modified": "2022-08-12T08:55:50.575Z"}, {"entity": "publication", "iuid": "9cc5dabbdf0a4825a47370d9e992c94b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9cc5dabbdf0a4825a47370d9e992c94b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9cc5dabbdf0a4825a47370d9e992c94b"}}, "title": "Suicide numbers during the first 9-15 months of the COVID-19 pandemic compared with pre-existing trends: An interrupted time series analysis in 33 countries.", "authors": [{"family": "Pirkis", "given": "Jane", "initials": "J"}, {"family": "Gunnell", "given": "David", "initials": "D"}, {"family": "Shin", "given": "Sangsoo", "initials": "S"}, {"family": "Del Pozo-Banos", "given": "Marcos", "initials": "M"}, {"family": "Arya", "given": "Vikas", "initials": "V"}, {"family": "Aguilar", "given": "Pablo Analuisa", "initials": "PA"}, {"family": "Appleby", "given": "Louis", "initials": "L"}, {"family": "Arafat", "given": "S M Yasir", "initials": "SMY"}, {"family": "Arensman", "given": "Ella", "initials": "E"}, {"family": "Ayuso-Mateos", "given": "Jose Luis", "initials": "JL"}, {"family": "Balhara", "given": "Yatan Pal Singh", "initials": "YPS"}, {"family": "Bantjes", "given": "Jason", "initials": "J"}, {"family": "Baran", "given": "Anna", "initials": "A"}, {"family": "Behera", "given": "Chittaranjan", "initials": "C"}, {"family": "Bertolote", "given": "Jose", "initials": "J"}, {"family": "Borges", "given": "Guilherme", "initials": "G"}, {"family": "Bray", "given": "Michael", "initials": "M"}, {"family": "Bre\u010di\u0107", "given": "Petrana", "initials": "P"}, {"family": "Caine", "given": "Eric", "initials": "E"}, {"family": "Calati", "given": "Raffaella", "initials": "R"}, {"family": "Carli", "given": "Vladimir", "initials": "V"}, {"family": "Castelpietra", "given": "Giulio", "initials": "G"}, {"family": "Chan", "given": "Lai Fong", "initials": "LF"}, {"family": "Chang", "given": "Shu-Sen", "initials": "SS"}, {"family": "Colchester", "given": "David", "initials": "D"}, {"family": "Coss-Guzm\u00e1n", "given": "Maria", "initials": "M"}, {"family": "Crompton", "given": "David", "initials": "D"}, {"family": "\u0106urkovi\u0107", "given": "Marko", "initials": "M"}, {"family": "Dandona", "given": "Rakhi", "initials": "R"}, {"family": "De Jaegere", "given": "Eva", "initials": "E"}, {"family": "De Leo", "given": "Diego", "initials": "D"}, {"family": "Deisenhammer", "given": "Eberhard A", "initials": "EA"}, {"family": "Dwyer", "given": "Jeremy", "initials": "J"}, {"family": "Erlangsen", "given": "Annette", "initials": "A"}, {"family": "Faust", "given": "Jeremy S", "initials": "JS"}, {"family": "Fornaro", "given": "Michele", "initials": "M"}, {"family": "Fortune", "given": "Sarah", "initials": "S"}, {"family": "Garrett", "given": "Andrew", "initials": "A"}, {"family": "Gentile", "given": "Guendalina", "initials": "G"}, {"family": "Gerstner", "given": "Rebekka", "initials": "R"}, {"family": "Gilissen", "given": "Renske", "initials": "R"}, {"family": "Gould", "given": "Madelyn", "initials": "M"}, {"family": "Gupta", "given": "Sudhir Kumar", "initials": "SK"}, {"family": "Hawton", "given": "Keith", "initials": "K"}, {"family": "Holz", "given": "Franziska", "initials": "F"}, {"family": "Kamenshchikov", "given": "Iurii", "initials": "I"}, {"family": "Kapur", "given": "Navneet", "initials": "N"}, {"family": "Kasal", "given": "Alexandr", "initials": "A"}, {"family": "Khan", "given": "Murad", "initials": "M"}, {"family": "Kirtley", "given": "Olivia J", "initials": "OJ"}, {"family": "Knipe", "given": "Duleeka", "initials": "D"}, {"family": "K\u00f5lves", "given": "Kairi", "initials": "K"}, {"family": "K\u00f6lzer", "given": "Sarah C", "initials": "SC"}, {"family": "Krivda", "given": "Hryhorii", "initials": "H"}, {"family": "Leske", "given": "Stuart", "initials": "S"}, {"family": "Madeddu", "given": "Fabio", "initials": "F"}, {"family": "Marshall", "given": "Andrew", "initials": "A"}, {"family": "Memon", "given": "Anjum", "initials": "A"}, {"family": "Mittendorfer-Rutz", "given": "Ellenor", "initials": "E"}, {"family": "Nestadt", "given": "Paul", "initials": "P"}, {"family": "Neznanov", "given": "Nikolay", "initials": "N"}, {"family": "Niederkrotenthaler", "given": "Thomas", "initials": "T"}, {"family": "Nielsen", "given": "Emma", "initials": "E"}, {"family": "Nordentoft", "given": "Merete", "initials": "M"}, {"family": "Oberlerchner", "given": "Herwig", "initials": "H"}, {"family": "O'Connor", "given": "Rory C", "initials": "RC"}, {"family": "Papsdorf", "given": "Rainer", "initials": "R"}, {"family": "Partonen", "given": "Timo", "initials": "T"}, {"family": "Phillips", "given": "Michael R", "initials": "MR"}, {"family": "Platt", "given": "Steve", "initials": "S"}, {"family": "Portzky", "given": "Gwendolyn", "initials": "G"}, {"family": "Psota", "given": "Georg", "initials": "G"}, {"family": "Qin", "given": "Ping", "initials": "P"}, {"family": "Radeloff", "given": "Daniel", "initials": "D"}, {"family": "Reif", "given": "Andreas", "initials": "A"}, {"family": "Reif-Leonhard", "given": "Christine", "initials": "C"}, {"family": "Rezaeian", "given": "Mohsen", "initials": "M"}, {"family": "Rom\u00e1n-V\u00e1zquez", "given": "Nayda", "initials": "N"}, {"family": "Roskar", "given": "Saska", "initials": "S"}, {"family": "Rozanov", "given": "Vsevolod", "initials": "V"}, {"family": "Sara", "given": "Grant", "initials": "G"}, {"family": "Scavacini", "given": "Karen", "initials": "K"}, {"family": "Schneider", "given": "Barbara", "initials": "B"}, {"family": "Semenova", "given": "Natalia", "initials": "N"}, {"family": "Sinyor", "given": "Mark", "initials": "M"}, {"family": "Tambuzzi", "given": "Stefano", "initials": "S"}, {"family": "Townsend", "given": "Ellen", "initials": "E"}, {"family": "Ueda", "given": "Michiko", "initials": "M"}, {"family": "Wasserman", "given": "Danuta", "initials": "D"}, {"family": "Webb", "given": "Roger T", "initials": "RT"}, {"family": "Winkler", "given": "Petr", "initials": "P"}, {"family": "Yip", "given": "Paul S F", "initials": "PSF"}, {"family": "Zalsman", "given": "Gil", "initials": "G"}, {"family": "Zoja", "given": "Riccardo", "initials": "R"}, {"family": "John", "given": "Ann", "initials": "A"}, {"family": "Spittal", "given": "Matthew J", "initials": "MJ"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": "51", "pages": "101573", "issn-l": null}, "abstract": "Predicted increases in suicide were not generally observed in the early months of the COVID-19 pandemic. However, the picture may be changing and patterns might vary across demographic groups. We aimed to provide a timely, granular picture of the pandemic's impact on suicides globally.\n\nWe identified suicide data from official public-sector sources for countries/areas-within-countries, searching websites and academic literature and contacting data custodians and authors as necessary. We sent our first data request on 22nd June 2021 and stopped collecting data on 31st October 2021. We used interrupted time series (ITS) analyses to model the association between the pandemic's emergence and total suicides and suicides by sex-, age- and sex-by-age in each country/area-within-country. We compared the observed and expected numbers of suicides in the pandemic's first nine and first 10-15 months and used meta-regression to explore sources of variation.\n\nWe sourced data from 33 countries (24 high-income, six upper-middle-income, three lower-middle-income; 25 with whole-country data, 12 with data for area(s)-within-the-country, four with both). There was no evidence of greater-than-expected numbers of suicides in the majority of countries/areas-within-countries in any analysis; more commonly, there was evidence of lower-than-expected numbers. Certain sex, age and sex-by-age groups stood out as potentially concerning, but these were not consistent across countries/areas-within-countries. In the meta-regression, different patterns were not explained by countries' COVID-19 mortality rate, stringency of public health response, economic support level, or presence of a national suicide prevention strategy. Nor were they explained by countries' income level, although the meta-regression only included data from high-income and upper-middle-income countries, and there were suggestions from the ITS analyses that lower-middle-income countries fared less well.\n\nAlthough there are some countries/areas-within-countries where overall suicide numbers and numbers for certain sex- and age-based groups are greater-than-expected, these countries/areas-within-countries are in the minority. Any upward movement in suicide numbers in any place or group is concerning, and we need to remain alert to and respond to changes as the pandemic and its mental health and economic consequences continue.\n\nNone.", "doi": "10.1016/j.eclinm.2022.101573", "pmid": "35935344", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(22)00303-0"}, {"db": "pmc", "key": "PMC9344880"}], "notes": [], "created": "2022-08-11T11:54:15.512Z", "modified": "2022-08-11T11:54:31.471Z"}, {"entity": "publication", "iuid": "e7bc0812ea3a459ca640b1d9f5195864", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e7bc0812ea3a459ca640b1d9f5195864.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e7bc0812ea3a459ca640b1d9f5195864"}}, "title": "Observed protection against SARS-CoV-2 reinfection following a primary infection: A Danish cohort study among unvaccinated using two years of nationwide PCR-test data.", "authors": [{"family": "Michlmayr", "given": "Daniela", "initials": "D"}, {"family": "Hansen", "given": "Christian Holm", "initials": "CH"}, {"family": "Gubbels", "given": "Sophie Madeleine", "initials": "SM"}, {"family": "Valentiner-Branth", "given": "Palle", "initials": "P"}, {"family": "Bager", "given": "Peter", "initials": "P"}, {"family": "Obel", "given": "Niels", "initials": "N"}, {"family": "Drewes", "given": "Birgitte", "initials": "B"}, {"family": "M\u00f8ller", "given": "Camilla Holten", "initials": "CH"}, {"family": "M\u00f8ller", "given": "Frederik Trier", "initials": "FT"}, {"family": "Legarth", "given": "Rebecca", "initials": "R"}, {"family": "M\u00f8lbak", "given": "K\u00e5re", "initials": "K"}, {"family": "Ethelberg", "given": "Steen", "initials": "S"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "20", "pages": "100452", "issn-l": null}, "abstract": "The level of protection after a SARS-CoV-2 infection against reinfection and COVID-19 disease remains important with much of the world still unvaccinated.\n\nAnalysing nationwide, individually referable, Danish register data including RT-PCR-test results, we conducted a cohort study using Cox regression to compare SARS-CoV-2 infection rates before and after a primary infection among still unvaccinated individuals, adjusting for sex, age, comorbidity and residency region. Estimates of protection against infection were calculated as 1 minus the hazard ratio. Estimates of protection against symptomatic infections and infections leading to hospitalisation were also calculated. The prevalence of infections classified as symptomatic or asymptomatic was compared for primary infections and reinfections. The study also assessed protection against each of the main viral variants after a primary infection with an earlier variant by restricting follow-up time to distinct, mutually exclusive periods during which each variant dominated.\n\nUntil 1 July 2021 the estimated protection against reinfection was 83.4% (95%CI: 82.2-84.6%); but lower for the 65+ year-olds (72.2%; 95%CI: 53.2-81.0%). Moderately higher estimates were found for protection against symptomatic disease, 88.3% overall (95%CI: 85.9-90.3%). First-time cases who reported no symptoms were more likely to experience a reinfection (odds ratio: 1.48; 95%CI: 1.35-1.62). By autumn 2021, when infections were almost exclusively caused by the Delta variant, the estimated protection following a recent first infection was 91.3% (95%CI: 89.7-92.7%) compared to 71.4% (95%CI: 66.9-75.3%) after a first infection over a year earlier. With Omicron, a first infection with an earlier variant in the past 3-6 months gave an estimated 51.0% (95%CI: 50.1-52.0%) protection, whereas a first infection longer than 12 months earlier provided only 19.0% (95%CI: 17.2-20.5%) protection. Protection by an earlier variant-infection against hospitalisation due to a new infection was estimated at: 86.6% (95%CI: 46.3-96.7%) for Alpha, 97.2% (95%CI: 89.0-99.3%) for Delta, and 69.8% (95%CI: 51.5-81.2%) for the Omicron variant.\n\nSARS-CoV-2 infection offered a high level of sustained protection against reinfection, comparable with that offered by vaccines, but decreased with the introduction of new main virus variants; dramatically so when Omicron appeared. Protection was lower among the elderly but appeared more pronounced following symptomatic compared to asymptomatic infections. The level of estimated protection against serious disease was somewhat higher than that against infection and possibly longer lasting. Decreases in protection against reinfection, seemed primarily to be driven by viral evolution.\n\nNone.", "doi": "10.1016/j.lanepe.2022.100452", "pmid": "35791335", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(22)00146-6"}, {"db": "pmc", "key": "PMC9245510"}], "notes": [], "created": "2022-08-17T13:07:20.171Z", "modified": "2022-08-17T13:07:20.177Z"}, {"entity": "publication", "iuid": "8794c597e5324ef1ab64bcd361a60c3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8794c597e5324ef1ab64bcd361a60c3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8794c597e5324ef1ab64bcd361a60c3d"}}, "title": "Initiation of antihypertensive drugs to patients with confirmed COVID-19-A population-based cohort study in Sweden.", "authors": [{"family": "Mousa", "given": "Salar Issa", "initials": "SI"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Hajiebrahimi", "given": "Mohammadhossein", "initials": "M", "orcid": "0000-0001-8118-4988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8338602bdf4d40ffb25713e73b1fc719.json"}}, {"family": "Bertilsson", "given": "Rebecka", "initials": "R"}, {"family": "N\u00e5tman", "given": "Jonatan", "initials": "J"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0003-0531-2516", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4911f8524d634e928a77f67c40e1610d.json"}}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Basic Clin Pharmacol Toxicol", "issn": "1742-7843", "volume": "131", "issue": "3", "pages": "196-204", "issn-l": null}, "abstract": "Hypertension is an important risk factor for severe outcomes in patients with COVID-19, and antihypertensive drugs may have a protective effect. However, the pandemic may have negatively impacted health care services for chronic diseases. The aim of this study was to assess initiations of antihypertensive medicines in patients infected by COVID-19.\n\nA cohort study including all Swedish residents 20-80 years old with a COVID-19 positive test compared with an unexposed group without COVID-19 matched for age, sex, and index date (date of confirmed COVID-19). Data were collected within SCIFI-PEARL, a study including linked data on COVID tests, hospital diagnoses, dispensed prescriptions, and socioeconomic data from Swedish national registers. Initiations of different antihypertensive drugs were studied from March 2020 until October 2020. Associations between COVID-19 and initiation of antihypertensives were assessed by a multivariable Cox proportional hazards model.\n\nA total of 224 582 patients (exposed and unexposed) were included. After adjusting for cardiovascular comorbidities and education level, ACEi was the most commonly initiated antihypertensive agent to patients with COVID-19. Hazard ratio and 95% confidence interval for initiation of drug therapy was 1.83 [1.53-2.19] for ACEi, followed by beta-blockers 1.74 [1.55-1.95], calcium channel blockers 1.61 [1.41-1.83], angiotensin receptor blockers 1.61 [1.40-1.86], and diuretics 1.53 [1.32-1.77].\n\nAll antihypertensive medicines were initiated more frequently in COVID-19 patients. This can either be associated with hypertension caused by the COVID-19 infection, more frequent diagnosis of hypertension among people with COVID-19 since they consult health care, or residual confounding factors not adjusted for in the study.", "doi": "10.1111/bcpt.13766", "pmid": "35726121", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9349802"}], "notes": [], "created": "2022-08-17T13:05:13.777Z", "modified": "2022-08-17T13:05:13.888Z"}, {"entity": "publication", "iuid": "3ac144a28cbb44b5bf6a5d2d018dd811", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ac144a28cbb44b5bf6a5d2d018dd811.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ac144a28cbb44b5bf6a5d2d018dd811"}}, "title": "Increased antidepressant use during the COVID-19 pandemic: Findings from the Friuli Venezia Giulia region, Italy, 2015-2020.", "authors": [{"family": "Pazzagli", "given": "Laura", "initials": "L"}, {"family": "Reutfors", "given": "Johan", "initials": "J"}, {"family": "Lucian", "given": "Ejlli", "initials": "E"}, {"family": "Zerial", "given": "Giovanna", "initials": "G"}, {"family": "Perulli", "given": "Alfredo", "initials": "A"}, {"family": "Castelpietra", "given": "Giulio", "initials": "G"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "volume": "315", "pages": "114704", "issn-l": null}, "abstract": "Few studies investigated the impact of the pandemic on antidepressant (AD) use.\n\nThe Social and Health Information System of Friuli Venezia Giulia region, Italy, provided data on AD use. Sex, age, AD class and month used the amount of AD prescriptions, measured by defined daily doses (DDD) per 1000 inhabitants per day, to compare AD use in 2020 with the period 2015-2019. A linear trend model predicted AD use for 2020, based on years 2015-2019.\n\nAD use was on average 20% higher in each month of 2020 when compared with the same month for the period 2015-2019, with an increase of more than 30% in the first four and in the last two months of 2020. The observed AD use in 2020 was higher than predicted, particularly in men, and in the 30-59 years age group.\n\nDescriptive study of AD use without analysis of data at the individual level. No information on psychiatric diagnoses of AD users.\n\nAD use was higher in the first year of the COVID-19 pandemic. Further research is warranted to understand if this may be related to a rise in mental disorders in the general population during the COVID-19 pandemic.", "doi": "10.1016/j.psychres.2022.114704", "pmid": "35830755", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(22)00300-6"}, {"db": "pmc", "key": "PMC9245333"}], "notes": [], "created": "2022-08-17T10:34:16.218Z", "modified": "2022-08-17T10:35:06.031Z"}, {"entity": "publication", "iuid": "7810c03718d54d36b6ca5230a6a64161", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7810c03718d54d36b6ca5230a6a64161.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7810c03718d54d36b6ca5230a6a64161"}}, "title": "Impaired immunity and high attack rates caused by SARS-CoV-2 variants among vaccinated long-term care facility residents.", "authors": [{"family": "Obach", "given": "Doroth\u00e9e", "initials": "D"}, {"family": "Solastie", "given": "Anna", "initials": "A", "orcid": "0000-0002-3848-2768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/95c7cbcd3ad843b4b74b9650e1d78f4a.json"}}, {"family": "Liedes", "given": "Oona", "initials": "O"}, {"family": "Vara", "given": "Saimi", "initials": "S"}, {"family": "Krzy\u017cewska-Dudek", "given": "Eva", "initials": "E", "orcid": "0000-0002-5581-1690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b24b973fe1674251af971a0112680320.json"}}, {"family": "Brinkmann", "given": "Luise", "initials": "L"}, {"family": "Haveri", "given": "Anu", "initials": "A", "orcid": "0000-0003-4620-7536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad75e87cc8d34f5cb3849a646d0e5e99.json"}}, {"family": "Hammer", "given": "Charlotte C", "initials": "CC"}, {"family": "Dub", "given": "Timoth\u00e9e", "initials": "T"}, {"family": "Meri", "given": "Seppo", "initials": "S", "orcid": "0000-0001-9142-501X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51708db39bbc477e9e94d09f99bab271.json"}}, {"family": "Freitag", "given": "Tobias L", "initials": "TL"}, {"family": "Lyytik\u00e4inen", "given": "Outi", "initials": "O"}, {"family": "Melin", "given": "Merit", "initials": "M"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Immun Inflamm Dis", "issn": "2050-4527", "volume": "10", "issue": "9", "pages": "e679", "issn-l": null}, "abstract": "Long-term care facilities (LTCF) residents are at high risk for severe coronavirus disease 2019 (COVID-19), and therefore, COVID-19 vaccinations were prioritized for residents and personnel in Finland at the beginning of 2021.\n\nWe investigated COVID-19 outbreaks in two LTCFs, where residents were once or twice vaccinated. After the outbreaks we measured immunoglobulin G (IgG) antibodies to severe acute respiratory syndrome coronavirus 2 spike glycoprotein, neutralizing antibody (NAb) titers, and cell-mediated immunity markers from residents and healthcare workers (HCWs).\n\nIn LTFC-1, the outbreak was caused by an Alpha variant (B.1.1.7) and the attack rate (AR) among once vaccinated residents was 23%. In LTCF-2 the outbreak was caused by a Beta variant (B.1.351). Its AR was 47% although all residents had received their second dose 1 month before the outbreak. We observed that vaccination had induced lower IgG concentrations, NAb titers and cell-mediated immune responses in residents compared to HCWs. Only 1/8 residents had NAb to the Beta variant after two vaccine doses.\n\nThe vaccinated elderly remain susceptible to breakthrough infections caused by Alpha and Beta variants. The weaker vaccine response in the elderly needs to be addressed in vaccination protocols, while new variants capable of evading vaccine-induced immunity continue to emerge.", "doi": "10.1002/iid3.679", "pmid": "36039644", "labels": {"Category: Vaccines": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9382858"}], "notes": [], "created": "2022-10-07T12:48:28.482Z", "modified": "2022-10-07T12:48:28.632Z"}, {"entity": "publication", "iuid": "8dbd78fd144c4e50a77459317b2f5262", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8dbd78fd144c4e50a77459317b2f5262.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8dbd78fd144c4e50a77459317b2f5262"}}, "title": "Immunomodulation by intravenous omega-3 fatty acid treatment in older subjects hospitalized for COVID-19: A single-blind randomized controlled trial.", "authors": [{"family": "Arnardottir", "given": "Hildur", "initials": "H", "orcid": "0000-0002-5163-3946", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/942fb973fd3e4a1e8f85c10e6fff4423.json"}}, {"family": "Pawelzik", "given": "Sven-Christian", "initials": "SC", "orcid": "0000-0001-8704-6607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5249b23453a347a883217f7c90cfeb00.json"}}, {"family": "Sarajlic", "given": "Philip", "initials": "P", "orcid": "0000-0002-8690-7994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a623ec0669142d889964c3a5697d109.json"}}, {"family": "Quaranta", "given": "Alessandro", "initials": "A", "orcid": "0000-0002-3167-3772", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7821ced4ee8842d69ae9081bde5278d7.json"}}, {"family": "Kolmert", "given": "Johan", "initials": "J"}, {"family": "Religa", "given": "Dorota", "initials": "D", "orcid": "0000-0003-4583-4570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e2c968ecffa4c638126d6d8d4a0dbd9.json"}}, {"family": "Wheelock", "given": "Craig E", "initials": "CE", "orcid": "0000-0002-8113-0653", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7fe4d1cc7804c6d9d1506dc8db516ea.json"}}, {"family": "B\u00e4ck", "given": "Magnus", "initials": "M", "orcid": "0000-0003-0853-5141", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a3a2ec52b7044719f83c4863b5cdb7b.json"}}], "type": "letter", "published": "2022-09-00", "journal": {"title": "Clin Transl Med", "issn": "2001-1326", "volume": "12", "issue": "9", "pages": "e895", "issn-l": null}, "abstract": null, "doi": "10.1002/ctm2.895", "pmid": "36121173", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9484265"}], "notes": [], "created": "2022-10-13T13:36:26.009Z", "modified": "2023-06-19T15:19:23.363Z"}, {"entity": "publication", "iuid": "884a9a950c48485eafe0e7de1980add6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/884a9a950c48485eafe0e7de1980add6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/884a9a950c48485eafe0e7de1980add6"}}, "title": "Geographical distribution of cystic fibrosis carriers as population genetic determinant of COVID-19 spread and fatality in 37 countries.", "authors": [{"family": "Gabbi", "given": "Chiara", "initials": "C"}, {"family": "Renieri", "given": "Alessandra", "initials": "A"}, {"family": "Strandvik", "given": "Birgitta", "initials": "B"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "J Infect", "issn": "1532-2742", "volume": "85", "issue": "3", "pages": "318-321", "issn-l": "0163-4453"}, "abstract": "COVID-19 has shown a relevant heterogeneity in spread and fatality among countries together with a significant variability in its clinical presentation, indicating that host genetic factors may influence COVID-19 pathogenicity. Indeed, subjects carrying single pathogenic variants of the Cystic Fibrosis (CF) Transmembrane Conductance Regulator (CFTR) gene - i.e. CF carriers - are more susceptible to respiratory tract infections and are more likely to undergo severe COVID-19 with higher risk of 14-day mortality. Given that CF carrier prevalence varies among ethnicities and nations, an ecological study in 37 countries was conducted, in order to determine to what extent the diverse CF carrier geographical distribution may have affected COVID-19 spread and fatality during the first pandemic wave. The CF prevalence in countries, as indicator of the geographical distribution of CF carriers, significantly correlated in a direct manner with both COVID-19 prevalence and its Case Fatality Rate (CFR). In a regression study weighted for the number of tests performed, COVID-19 prevalence positively correlated with CF prevalence, while CFR correlated with population percentage older than 65-year, cancer and CF prevalence. Multivariate regression model also confirmed COVID-19 CFR to be associated with CF prevalence, after adjusting for elderly, cancer prevalence, and weighting for the number of tests performed. This study suggests a putative contribution of population genetics of CFTR in understanding the spatial distribution of COVID-19 spread and fatality.", "doi": "10.1016/j.jinf.2022.06.006", "pmid": "35700866", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0163-4453(22)00359-0"}, {"db": "pmc", "key": "PMC9188282"}], "notes": [], "created": "2022-06-20T18:15:47.594Z", "modified": "2022-08-17T13:01:42.707Z"}, {"entity": "publication", "iuid": "3806cd89b54a4248bc55b0da0ad24174", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3806cd89b54a4248bc55b0da0ad24174.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3806cd89b54a4248bc55b0da0ad24174"}}, "title": "Design and Analysis of Studies Based on Hierarchical Composite Endpoints: Insights from the DARE-19 Trial.", "authors": [{"family": "Gasparyan", "given": "Samvel B", "initials": "SB", "orcid": "0000-0002-4797-2208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fe0aea6b8d940a4aa97beac64753452.json"}}, {"family": "Buenconsejo", "given": "Joan", "initials": "J", "orcid": "0000-0003-4514-2208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90cef2fa64d0486681f64332929d92cf.json"}}, {"family": "Kowalewski", "given": "Elaine K", "initials": "EK", "orcid": "0000-0002-7915-877X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0c063ae9205470c9803add8044303bc.json"}}, {"family": "Oscarsson", "given": "Jan", "initials": "J", "orcid": "0000-0002-4573-517X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40a4f5060bd147c08b93f49e441ed37c.json"}}, {"family": "Bengtsson", "given": "Olof F", "initials": "OF", "orcid": "0000-0003-1315-8176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ae11bf6102548649d358e95a3f44766.json"}}, {"family": "Esterline", "given": "Russell", "initials": "R"}, {"family": "Koch", "given": "Gary G", "initials": "GG"}, {"family": "Berwanger", "given": "Otavio", "initials": "O"}, {"family": "Kosiborod", "given": "Mikhail N", "initials": "MN"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Ther Innov Regul Sci", "issn": "2168-4804", "volume": "56", "issue": "5", "pages": "785-794", "issn-l": null}, "abstract": "DARE-19 (NCT04350593) was a randomized trial studying the effects of dapagliflozin, an SGLT2 inhibitor, in hospitalized patients with COVID-19 pneumonia and cardiometabolic risk factors. The conduct of DARE-19 offered the opportunity to define an innovative and clinically meaningful endpoint in a new disease that would best reflect the known profile of dapagliflozin, accompanied by the statistical challenges of analysis and interpretation of such a novel endpoint.\n\nHierarchical composite endpoints (HCEs) are based on clinical outcomes which, unlike traditional composite endpoints incorporate ranking of components according to clinical importance. Design of an HCE requires the clinical considerations specific to the therapeutic area under study and the mechanism of action of the investigational treatment. Statistical aspects for the clinical endpoints include the proper definition of the estimand as suggested by ICH E9(R1) for the precise specification of the treatment effect measured by an HCE.\n\nWe describe the estimand of the DARE-19 trial, where an HCE was constructed to capture the treatment effect of dapagliflozin in hospitalized patients with COVID-19, and was analyzed using a win odds. Practical aspects of designing new studies based on an HCE are described. These include sample size, power, and minimal detectable effect calculations for an HCE based on the win odds analysis, as well as handling of missing data and the clinical interpretability of the win odds in relation to the estimand.\n\nHCEs are flexible endpoints that can be adapted for use in different therapeutic areas, with win odds as the analysis method. DARE-19 is an example of a COVID-19 trial with an HCE as one of the primary endpoints for estimating a clinically interpretable treatment effect in the COVID-19 setting.", "doi": "10.1007/s43441-022-00420-1", "pmid": "35699910", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s43441-022-00420-1"}, {"db": "pmc", "key": "PMC9196151"}], "notes": [], "created": "2022-06-20T18:16:07.446Z", "modified": "2022-08-17T13:02:09.052Z"}, {"entity": "publication", "iuid": "8101495174ac4c04b2cfde72073ef8fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8101495174ac4c04b2cfde72073ef8fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8101495174ac4c04b2cfde72073ef8fa"}}, "title": "COVID-19 clinical outcomes and DMT of MS patients and population-based controls.", "authors": [{"family": "Longinetti", "given": "Elisa", "initials": "E", "orcid": "0000-0002-4789-7172", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c376d8f47e6b4624861918e0f33abb6f.json"}}, {"family": "Bower", "given": "Hannah", "initials": "H"}, {"family": "McKay", "given": "Kyla A", "initials": "KA", "orcid": "0000-0002-9081-1522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8049ba5c52eb42c7bb866f5eee749173.json"}}, {"family": "Englund", "given": "Simon", "initials": "S", "orcid": "0000-0002-1042-4400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f87dfdb3db6f49d385f5266fa53e6262.json"}}, {"family": "Burman", "given": "Joachim", "initials": "J"}, {"family": "Fink", "given": "Katharina", "initials": "K"}, {"family": "Fogdell-Hahn", "given": "Anna", "initials": "A"}, {"family": "Gunnarsson", "given": "Martin", "initials": "M"}, {"family": "Hillert", "given": "Jan", "initials": "J"}, {"family": "Langer-Gould", "given": "Annette", "initials": "A", "orcid": "0000-0001-6891-7147", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fae9d189a7444ecc91c521031c9c1f9b.json"}}, {"family": "Lycke", "given": "Jan", "initials": "J"}, {"family": "Nilsson", "given": "Petra", "initials": "P"}, {"family": "Salzer", "given": "Jonatan", "initials": "J"}, {"family": "Svenningsson", "given": "Anders", "initials": "A"}, {"family": "Mellerg\u00e5rd", "given": "Johan", "initials": "J"}, {"family": "Olsson", "given": "Tomas", "initials": "T"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Frisell", "given": "Thomas", "initials": "T", "orcid": "0000-0002-5735-9626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e9d6be8c47b4d6eb80bd3d57a63172e.json"}}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Ann Clin Transl Neurol", "issn": "2328-9503", "volume": "9", "issue": "9", "pages": "1449-1458", "issn-l": "2328-9503"}, "abstract": "To estimate risks for all-cause mortality and for severe COVID-19 in multiple sclerosis patients and across relapsing-remitting multiple sclerosis patients exposed to disease-modifying therapies.\n\nWe conducted a Swedish nationwide population-based multi-register linkage cohort study and followed all multiple sclerosis patients (n = 17,692 in March 2020), individually age-, sex-, and region-matched to five population-based controls (n = 86,176 in March 2020) during March 2020-June 2021. We compared annual all-cause mortality within and across cohorts, and assessed incidence rates and relative risks for hospitalization, intensive care admission, and death due to COVID-19 in relation to disease-modifying therapy use, using Cox regression.\n\nAbsolute all-cause mortality among multiple sclerosis patients was higher from March to December 2020 than in previous years, but relative risks versus the population-based controls were similar to preceding years. Incidence rates of hospitalization, intensive care admission, and death due to COVID-19 remained in line with those for all-cause hospitalization, intensive care admission, and mortality. Among relapsing-remitting patients on rituximab, trends for differences in risk of hospitalization due to COVID-19 remained in the demographics-, socioeconomic status-, comorbidity-, and multiple sclerosis severity-adjusted model.\n\nRisks of severe COVID-19-related outcomes were increased among multiple sclerosis patients as a whole compared to population controls, but risk increases were also seen for non-COVID-19 hospitalization, intensive care admission, and mortality, and did not significantly differ during the pandemic compared to pre-pandemic years. The risk conveyed by disease-modifying therapies was smaller than previously assumed, likely as a consequence of the possibility to better control for confounders.", "doi": "10.1002/acn3.51646", "pmid": "35993445", "labels": {"Category: Biochemistry": null, "Research Area: Vaccine": null, "Funder: VR": null, "Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:54:21.518Z", "modified": "2022-09-12T18:54:33.463Z"}, {"entity": "publication", "iuid": "54071614f63543689180c5efe559a5f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54071614f63543689180c5efe559a5f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54071614f63543689180c5efe559a5f1"}}, "title": "Age-specific associations between underlying health conditions and hospitalisation, death and in-hospital death among confirmed COVID-19 cases: a multi-country study based on surveillance data, June to December 2020.", "authors": [{"family": "Funk", "given": "Tjede", "initials": "T"}, {"family": "Innocenti", "given": "Francesco", "initials": "F"}, {"family": "Gomes Dias", "given": "Joana", "initials": "J"}, {"family": "Nerlander", "given": "Lina", "initials": "L"}, {"family": "Melillo", "given": "Tanya", "initials": "T"}, {"family": "Gauci", "given": "Charmaine", "initials": "C"}, {"family": "Melillo", "given": "Jackie M", "initials": "JM"}, {"family": "Lenz", "given": "Patrik", "initials": "P"}, {"family": "Sebestova", "given": "Helena", "initials": "H"}, {"family": "Slezak", "given": "Pavel", "initials": "P"}, {"family": "Vlckova", "given": "Iva", "initials": "I"}, {"family": "Berild", "given": "Jacob Dag", "initials": "JD"}, {"family": "Mauroy", "given": "Camilla", "initials": "C"}, {"family": "Sepp\u00e4l\u00e4", "given": "Elina", "initials": "E"}, {"family": "T\u00f8nnessen", "given": "Ragnhild", "initials": "R"}, {"family": "Vergison", "given": "Anne", "initials": "A"}, {"family": "Mossong", "given": "Jo\u00ebl", "initials": "J"}, {"family": "Masi", "given": "Silvana", "initials": "S"}, {"family": "Huiart", "given": "Laetitia", "initials": "L"}, {"family": "Cullen", "given": "Gillian", "initials": "G"}, {"family": "Murphy", "given": "Niamh", "initials": "N"}, {"family": "O'Connor", "given": "Lois", "initials": "L"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}, {"family": "Mook", "given": "Piers", "initials": "P"}, {"family": "Pebody", "given": "Richard G", "initials": "RG"}, {"family": "Bundle", "given": "Nick", "initials": "N"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "27", "issue": "35", "issn-l": null}, "abstract": "BackgroundUnderlying conditions are risk factors for severe COVID-19 outcomes but evidence is limited about how risks differ with age.AimWe sought to estimate age-specific associations between underlying conditions and hospitalisation, death and in-hospital death among COVID-19 cases.MethodsWe analysed case-based COVID-19 data submitted to The European Surveillance System between 2 June and 13 December 2020 by nine European countries. Eleven underlying conditions among cases with only one condition and the number of underlying conditions among multimorbid cases were used as exposures. Adjusted odds ratios (aOR) were estimated using 39 different age-adjusted and age-interaction multivariable logistic regression models, with marginal means from the latter used to estimate probabilities of severe outcome for each condition-age group combination.ResultsCancer, cardiac disorder, diabetes, immunodeficiency, kidney, liver and lung disease, neurological disorders and obesity were associated with elevated risk (aOR: 1.5-5.6) of hospitalisation and death, after controlling for age, sex, reporting period and country. As age increased, age-specific aOR were lower and predicted probabilities higher. However, for some conditions, predicted probabilities were at least as high in younger individuals with the condition as in older cases without it. In multimorbid patients, the aOR for severe disease increased with number of conditions for all outcomes and in all age groups.ConclusionWhile supporting age-based vaccine roll-out, our findings could inform a more nuanced, age- and condition-specific approach to vaccine prioritisation. This is relevant as countries consider vaccination of younger people, boosters and dosing intervals in response to vaccine escape variants.", "doi": "10.2807/1560-7917.ES.2022.27.35.2100883", "pmid": "36052721", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9438397"}], "notes": [], "created": "2022-10-13T13:20:13.681Z", "modified": "2022-10-13T13:20:29.741Z"}, {"entity": "publication", "iuid": "cb78eca0dc3f4bbdba776bbbb624f273", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cb78eca0dc3f4bbdba776bbbb624f273.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cb78eca0dc3f4bbdba776bbbb624f273"}}, "title": "Acute Stress among Nurses in Sweden during the COVID-19 Pandemic.", "authors": [{"family": "Palmborg", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "L\u00f6tvall", "given": "Rebecka", "initials": "R"}, {"family": "Carde\u00f1a", "given": "Etzel", "initials": "E"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Eur J Trauma Dissociation", "issn": "2468-7499", "issn-l": null, "volume": "6", "issue": "3", "pages": "100283"}, "abstract": "Sweden was hit hard in the beginning of the COVID-19 pandemic with deaths per capita among the highest in Europe. The pandemic was a stressful time especially for healthcare workers caring for COVID-19 patients. Various studies have evaluated whether nurses caring for these patients had higher levels of acute stress, but typically with measures that either used older DSM-IV criteria for Acute Stress Disorder (ASD) or general measures of acute stress. We recruited an online sample (N = 101) of nurses in Sweden from COVID-19 specialized units (ICU), Emergency (ER), and other units (Other), and asked them to answer questionnaires retrospectively to the peak of infections in Sweden. We aimed to evaluate: 1) the psychometric properties of the translation of the Stanford Acute Stress Reaction Questionnaire-II (SASRQ-II, which follows DSM-5 criteria for ASD) into Swedish, 2) whether nurses in COVID-19 units had experienced more acute stress than nurses in other units, and 3) the extent of potential acute stress disorder. The SASRQ-II evidenced good construct, convergent and divergent validity, and good reliability. It showed that ICU nurses reported significantly more acute stress than the other two groups, a difference that could not be accounted for by demographic or other variables. A retrospective diagnosis of ASD using the SASRQ-II suggested that 60% of nurses might have fulfilled ASD criteria, but no differences across groups were found.", "doi": "10.1016/j.ejtd.2022.100283", "pmid": "37521718", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC9153182"}, {"db": "pii", "key": "S2468-7499(22)00025-4"}], "notes": [], "created": "2023-10-04T12:10:42.579Z", "modified": "2023-10-04T13:29:52.549Z"}, {"entity": "publication", "iuid": "1de3abb226014908b7f0b2e74a72bc10", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1de3abb226014908b7f0b2e74a72bc10.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1de3abb226014908b7f0b2e74a72bc10"}}, "title": "Computational investigation of the increased virulence and pathogenesis of SARS-CoV-2 lineage B.1.1.7.", "authors": [{"family": "Murugan", "given": "N Arul", "initials": "NA", "orcid": "0000-0003-0185-5724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/293acfd743f94993bd6aca57b01cd604.json"}}, {"family": "Javali", "given": "Prashanth S", "initials": "PS"}, {"family": "Pandianb", "given": "Chitra Jeyaraj", "initials": "CJ"}, {"family": "Ali", "given": "Muhammad Akhtar", "initials": "MA"}, {"family": "Srivastava", "given": "Vaibhav", "initials": "V"}, {"family": "Jeyaraman", "given": "Jeyakanthan", "initials": "J"}], "type": "journal article", "published": "2022-08-31", "journal": {"title": "Phys Chem Chem Phys", "issn": "1463-9084", "volume": "24", "issue": "34", "pages": "20371-20380", "issn-l": null}, "abstract": "New variants of SARS-CoV-2 are being reported worldwide. The World Health Organization has reported Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2) and Omicron (B.1.1.529) as the variants of concern. There are speculations that the variants might evade the host immune responses induced by currently available vaccines and develop resistance to drugs under consideration. The first step of viral infection in COVID-19 occurs through the interaction of the spike protein's receptor-binding domain (RBD) with the peptidase domain of the human ACE-2 (hACE-2) receptor. This study aims to get a molecular-level understanding of the mechanism behind the increased infection rate in the alpha variant. We have computationally studied the spike protein interaction in both the wild-type and B.1.1.7 variant with the hACE-2 receptor using molecular dynamics and MM-GBSA based binding free energy calculations. The binding free energy difference shows that the mutant variant of the spike protein has increased binding affinity for the hACE-2 receptor (i.e. \u0394G(N501Y,A570D) is in the range -7.2 to -7.6 kcal mol-1) and the results were validated using Density functional theory. We demonstrate that with the use of state-of-the-art computational approaches, we can, in advance, predict the virulent nature of variants of SARS-CoV-2 and alert the world healthcare system.", "doi": "10.1039/d2cp00469k", "pmid": "35983778", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:46:02.036Z", "modified": "2022-09-12T18:46:11.422Z"}, {"entity": "publication", "iuid": "95b56a5bc5fd4409a812fb103435b7f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95b56a5bc5fd4409a812fb103435b7f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95b56a5bc5fd4409a812fb103435b7f8"}}, "title": "Target trial emulation: applying principles of randomised trials to observational studies.", "authors": [{"family": "Matthews", "given": "Anthony A", "initials": "AA"}, {"family": "Danaei", "given": "Goodarz", "initials": "G"}, {"family": "Islam", "given": "Nazrul", "initials": "N"}, {"family": "Kurth", "given": "Tobias", "initials": "T"}], "type": "journal article", "published": "2022-08-30", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "378", "pages": "e071108", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj-2022-071108", "pmid": "36041749", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-10-07T12:52:13.418Z", "modified": "2022-10-07T12:52:13.430Z"}, {"entity": "publication", "iuid": "7aea51599cb44f5bbd01b5b25ee4a2c3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7aea51599cb44f5bbd01b5b25ee4a2c3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7aea51599cb44f5bbd01b5b25ee4a2c3"}}, "title": "Standing alone: experiences of vaccine-hesitant Danish healthcare professionals during COVID-19.", "authors": [{"family": "Mars\u00e5", "given": "Kristoffer", "initials": "K"}, {"family": "Kristensen", "given": "Tina B\u00f8gelund", "initials": "TB", "orcid": "0000-0002-1337-2714", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04953b581b8d473f8775c9129a9cc439.json"}}, {"family": "Konradsen", "given": "Hanne", "initials": "H", "orcid": "0000-0002-7477-125X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b462d15cdeec4dcb8371e07cf2e97853.json"}}], "type": "journal article", "published": "2022-08-29", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "14034948221113645", "issn-l": "1403-4948"}, "abstract": "The aim of the study was to explore the experiences of Danish healthcare professionals who were hesitant about the COVID-19 vaccine.\n\nInterviews were conducted over the telephone in January and February 2021.\n\nHealthcare professionals experienced the need to avoid impossible conversations about vaccine hesitancy with their colleagues. They felt a lack of knowledge of long-term experience with the vaccine and a need to balance trust in themselves and the authorities.\n\nHealthcare professionals who were hesitant towards the COVID-19 vaccine felt they had to keep their concerns to themselves and felt isolated and pressured by their managers. This study is especially important for managers, who must ensure a trusting working environment in which employees can discuss their concerns without feeling pressured.", "doi": "10.1177/14034948221113645", "pmid": "36032021", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9425156"}], "notes": [], "created": "2022-10-07T12:42:10.132Z", "modified": "2022-10-07T12:42:10.202Z"}, {"entity": "publication", "iuid": "a10443d35eb74f0f9cf02dc552aa961f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a10443d35eb74f0f9cf02dc552aa961f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a10443d35eb74f0f9cf02dc552aa961f"}}, "title": "Early coronavirus disease 2019 restrictive measures and changes in maternal characteristics, use of assisted reproductive technology, and stillbirth.", "authors": [{"family": "Lisonkova", "given": "Sarka", "initials": "S", "orcid": "0000-0002-1220-310X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fa6497ba976450d811710f9d17d7cdf.json"}}, {"family": "Bone", "given": "Jeffrey N", "initials": "JN", "orcid": "0000-0001-7704-1677", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89c39d4178c944cda324b0f521aa290f.json"}}, {"family": "Muraca", "given": "Giulia M", "initials": "GM"}, {"family": "Razaz", "given": "Neda", "initials": "N", "orcid": "0000-0002-1273-0110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f21859df7854ccba80df15feb16afe1.json"}}, {"family": "Boutin", "given": "Amelie", "initials": "A", "orcid": "0000-0003-1907-2920", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cc105166eb549ed85144b0066c7cb8c.json"}}, {"family": "Brandt", "given": "Justin S", "initials": "JS", "orcid": "0000-0002-3194-1087", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90c6660c689c499c996f99485ece89f5.json"}}, {"family": "Bedaiwy", "given": "Mohamed A", "initials": "MA"}, {"family": "Ananth", "given": "Cande V", "initials": "CV", "orcid": "0000-0002-0410-2595", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/efc995667f254ca7b334d8acb15bf40c.json"}}, {"family": "Joseph", "given": "K S", "initials": "KS", "orcid": "0000-0003-2317-5607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56f6530185df4ed0884f76187da81fc1.json"}}], "type": "journal article", "published": "2022-08-29", "journal": {"title": "Paediatr Perinat Epidemiol", "issn": "1365-3016", "issn-l": null}, "abstract": "The initial COVID-19 pandemic response-related effects on conceptions following the use of assisted reproductive technologies (ART), and on changes in the maternal characteristics of women who conceived during the early vs. pre-pandemic period, have been understudied.\n\nTo examine the effects of ART clinic closures in the United States (US) in March 2020 on the frequency of ART-conceived live births, multiple births and stillbirths; and to describe changes in the characteristics of women who conceived in the early pandemic period.\n\nPopulation-based cohort study including all births in the US from January 2015 to December 2020 (22,907,688 live births; 134,537 stillbirths). Interrupted time series (ITS) methodology was used to estimate rate ratios (RR) of expected versus observed rates in December 2020 (i.e., among births conceived mainly in March 2020). Demographic and clinical characteristics were compared between mothers who conceived in March 2020 versus March 2015-2019.\n\nOverall, 1.1% of live births and 1.7% of stillbirths were conceived by ART. ART-conceived live births decreased by 57.0% in December 2020 (observed vs. expected RR 0.43, 95% confidence interval [CI] 0.40, 0.45), and these declines occurred in all subgroups of women. Multiple births also declined in December 2020. Stillbirth rates increased in December 2020 in ART-conceived births (RR 2.55, 95% CI 1.63, 3.92) but remained unchanged in the non-ART group. Maternal characteristics of women who conceived in the early pandemic versus pre-pandemic period differed and included an increased prevalence of pre-pregnancy obesity class 3 and chronic hypertension.\n\nThe early pandemic closure of ART clinics resulted in a substantial decline in ART-conceived live births and multiple births in December 2020 and an increase in the proportion of stillbirths among ART-conceived births. Women who conceived in the early pandemic period also had an increased prevalence of obesity and chronic hypertension.", "doi": "10.1111/ppe.12925", "pmid": "36038519", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-10-07T12:46:40.148Z", "modified": "2022-10-07T12:46:40.410Z"}, {"entity": "publication", "iuid": "3b7806103bd5433bb21a91e8f197bef2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b7806103bd5433bb21a91e8f197bef2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b7806103bd5433bb21a91e8f197bef2"}}, "title": "Vascular Aging and COVID-19.", "authors": [{"family": "Badaras", "given": "Ignas", "initials": "I", "orcid": "0000-0002-9423-6641", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/454778bb8e734071b6de754a38336a45.json"}}, {"family": "Lau\u010dyt\u0117-Cibulskien\u0117", "given": "Agn\u0117", "initials": "A"}], "type": "journal article", "published": "2022-08-28", "journal": {"title": "Angiology", "issn": "1940-1574", "pages": "33197221121007", "issn-l": null}, "abstract": "Vascular age is determined by functional and structural changes in the arterial wall. When measured by its proxy, pulse wave velocity, it has been shown to predict cardiovascular and total mortality. Disconcordance between chronological and vascular age might represent better or worse vascular health. Cell senescence is caused by oxidative stress and sustained cell replication. Senescent cells acquire senescence-associated secretory phenotype. Oxidative stress, endothelial dysfunction, dysregulation of coagulation and leucocyte infiltration are observed in the aging endothelium. All of these mechanisms lead to increased vascular calcification and stiffness. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can involve the vascular endothelium. It enters cells using angiotensin-converting enzyme 2 (ACE-2) receptors, which are abundant in endothelial cells. The damage this virus does to the endothelium can be direct or indirect. Indirect damage is caused by hyperinflammation. Direct damage results from effects on ACE-2 receptors. The reduction of ACE-2 levels seen during coronavirus disease 2019 (COVID-19) infection might cause vasoconstriction and oxidative stress. COVID-19 and vascular aging share some pathways. Due to the novelty of the virus, there is an urgent need for studies that investigate its long-term effects on vascular health.", "doi": "10.1177/00033197221121007", "pmid": "36031949", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9421419"}], "notes": [], "created": "2022-10-07T12:41:44.367Z", "modified": "2022-10-07T12:41:44.456Z"}, {"entity": "publication", "iuid": "40f0eb51bec5406f9a482adfb5912ef0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/40f0eb51bec5406f9a482adfb5912ef0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/40f0eb51bec5406f9a482adfb5912ef0"}}, "title": "Impact of the COVID-19 pandemic on total, sex- and age-specific all-cause mortality in 20 countries worldwide during 2020: results from the C-MOR project.", "authors": [{"family": "Demetriou", "given": "Christiana A", "initials": "CA"}, {"family": "Achilleos", "given": "Souzana", "initials": "S"}, {"family": "Quattrocchi", "given": "Annalisa", "initials": "A"}, {"family": "Gabel", "given": "John", "initials": "J"}, {"family": "Critselis", "given": "Elena", "initials": "E"}, {"family": "Constantinou", "given": "Constantina", "initials": "C"}, {"family": "Nicolaou", "given": "Nicoletta", "initials": "N"}, {"family": "Ambrosio", "given": "Giuseppe", "initials": "G"}, {"family": "Bennett", "given": "Catherine M", "initials": "CM"}, {"family": "Le Meur", "given": "Nolwenn", "initials": "N", "orcid": "0000-0001-8451-4014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7ccd56127144ac4b7044dfaf98ca8e6.json"}}, {"family": "Critchley", "given": "Julia A", "initials": "JA"}, {"family": "Mortensen", "given": "Laust Hvas", "initials": "LH"}, {"family": "Rodriguez-Llanes", "given": "Jose Manuel", "initials": "JM", "orcid": "0000-0003-3736-736X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/63855d33d8924205b7a3f4cf7f826ee2.json"}}, {"family": "Chong", "given": "Mario", "initials": "M"}, {"family": "Denissov", "given": "Gleb", "initials": "G"}, {"family": "Klepac", "given": "Petra", "initials": "P"}, {"family": "Goldsmith", "given": "Lucy P", "initials": "LP"}, {"family": "Costa", "given": "Antonio Jos\u00e9 Leal", "initials": "AJL"}, {"family": "Hagen", "given": "Terje P", "initials": "TP"}, {"family": "Chan Sun", "given": "Marie", "initials": "M"}, {"family": "Huang", "given": "Qian", "initials": "Q"}, {"family": "Pidmurniak", "given": "Nataliia", "initials": "N"}, {"family": "Zucker", "given": "Inbar", "initials": "I"}, {"family": "Cuthbertson", "given": "Joseph", "initials": "J"}, {"family": "Burstr\u00f6m", "given": "Bo", "initials": "B"}, {"family": "Barron", "given": "Manuel", "initials": "M"}, {"family": "Er\u017een", "given": "Ivan", "initials": "I"}, {"family": "Stracci", "given": "Fabrizio", "initials": "F"}, {"family": "Calmon", "given": "Wilson", "initials": "W"}, {"family": "Martial", "given": "Cyndy", "initials": "C"}, {"family": "Verstiuk", "given": "Olesia", "initials": "O"}, {"family": "Kaufman", "given": "Zalman", "initials": "Z"}, {"family": "Tao", "given": "Wenjing", "initials": "W"}, {"family": "Kereselidze", "given": "Maia", "initials": "M"}, {"family": "Chikhladze", "given": "Nino", "initials": "N"}, {"family": "Polemitis", "given": "Antonis", "initials": "A"}, {"family": "Charalambous", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2022-08-27", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "issn-l": "0300-5771"}, "abstract": "To understand the impact of the COVID-19 pandemic on mortality, this study investigates overall, sex- and age-specific excess all-cause mortality in 20 countries, during 2020.\n\nTotal, sex- and age-specific weekly all-cause mortality for 2015-2020 was collected from national vital statistics databases. Excess mortality for 2020 was calculated by comparing weekly 2020 observed mortality against expected mortality, estimated from historical data (2015-2019) accounting for seasonality, long- and short-term trends. Crude and age-standardized rates were analysed for total and sex-specific mortality.\n\nAustria, Brazil, Cyprus, England and Wales, France, Georgia, Israel, Italy, Northern Ireland, Peru, Scotland, Slovenia, Sweden, and the USA displayed substantial excess age-standardized mortality of varying duration during 2020, while Australia, Denmark, Estonia, Mauritius, Norway, and Ukraine did not. In sex-specific analyses, excess mortality was higher in males than females, except for Slovenia (higher in females) and Cyprus (similar in both sexes). Lastly, for most countries substantial excess mortality was only detectable (Austria, Cyprus, Israel, and Slovenia) or was higher (Brazil, England and Wales, France, Georgia, Italy, Northern Ireland, Sweden, Peru and the USA) in the oldest age group investigated. Peru demonstrated substantial excess mortality even in the <45 age group.\n\nThis study highlights that excess all-cause mortality during 2020 is context dependent, with specific countries, sex- and age-groups being most affected. As the pandemic continues, tracking excess mortality is important to accurately estimate the true toll of COVID-19, while at the same time investigating the effects of changing contexts, different variants, testing, quarantine, and vaccination strategies.", "doi": "10.1093/ije/dyac170", "pmid": "36029524", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6678067"}, {"db": "pmc", "key": "PMC9452146"}], "notes": [], "created": "2022-10-07T12:39:47.036Z", "modified": "2022-10-07T12:39:47.118Z"}, {"entity": "publication", "iuid": "f128d077fdaf4127bdbe1a3b9f04c3af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f128d077fdaf4127bdbe1a3b9f04c3af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f128d077fdaf4127bdbe1a3b9f04c3af"}}, "title": "Presentations of children to emergency departments across Europe and the COVID-19 pandemic: A multinational observational study.", "authors": [{"family": "Nijman", "given": "Ruud G", "initials": "RG", "orcid": "0000-0001-9671-8161", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26477162984840c0bf7a96f496f7c297.json"}}, {"family": "Honeyford", "given": "Kate", "initials": "K", "orcid": "0000-0002-5533-7693", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/106c36a2e1a8490686043452d0913882.json"}}, {"family": "Farrugia", "given": "Ruth", "initials": "R", "orcid": "0000-0002-1553-2486", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a73c5db5b3014380ac3872f27d73b578.json"}}, {"family": "Rose", "given": "Katy", "initials": "K", "orcid": "0000-0002-2020-4161", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be8a1e5aaf9c45b4a154d0f8a03d9974.json"}}, {"family": "Bognar", "given": "Zsolt", "initials": "Z", "orcid": "0000-0002-3744-9333", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e785ea593bba4834bdc5e3f23ddb815d.json"}}, {"family": "Buonsenso", "given": "Danilo", "initials": "D", "orcid": "0000-0001-8567-2639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e070622b9414c78b60ffe8128c2b199.json"}}, {"family": "Da Dalt", "given": "Liviana", "initials": "L", "orcid": "0000-0003-2977-3907", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e19bb4da28564137afdfb37221e0ed5c.json"}}, {"family": "De", "given": "Tisham", "initials": "T", "orcid": "0000-0001-7278-0534", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/326ea5db5b964d999e5476cd57954362.json"}}, {"family": "Maconochie", "given": "Ian K", "initials": "IK", "orcid": "0000-0001-6319-8550", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4777830b1d77433d8415df99b156c9d5.json"}}, {"family": "Parri", "given": "Niccolo", "initials": "N", "orcid": "0000-0002-8098-2504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b286f0ff29b402da7baa7f2fd324a1f.json"}}, {"family": "Roland", "given": "Damian", "initials": "D", "orcid": "0000-0001-9334-5144", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd56730130484fc29a5e6c8e30d39146.json"}}, {"family": "Alfven", "given": "Tobias", "initials": "T", "orcid": "0000-0002-2328-3512", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3851560b984401780a380ab1262cd8b.json"}}, {"family": "Aupiais", "given": "Camille", "initials": "C", "orcid": "0000-0001-7482-0405", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d81b1aa343a43129b778f6ff77da0f7.json"}}, {"family": "Barrett", "given": "Michael", "initials": "M", "orcid": "0000-0003-1775-8347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/55f3b1f81f834837af0d4e3d5c6a10bb.json"}}, {"family": "Basmaci", "given": "Romain", "initials": "R"}, {"family": "Borensztajn", "given": "Dorine", "initials": "D", "orcid": "0000-0002-2437-0757", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/916d54dab1494022b1e099689d96afe2.json"}}, {"family": "Castanhinha", "given": "Susana", "initials": "S", "orcid": "0000-0003-0762-7730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c3142588768e44a181ffeb24f1fc3968.json"}}, {"family": "Vasilico", "given": "Corrine", "initials": "C", "orcid": "0000-0001-8911-1097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/622935bca334454295b551f4b1a4ddd6.json"}}, {"family": "Durnin", "given": "Sheena", "initials": "S", "orcid": "0000-0002-5109-3417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ddf91f56cbd41e799cb59f67331a5dd.json"}}, {"family": "Fitzpatrick", "given": "Paddy", "initials": "P"}, {"family": "Fodor", "given": "Laszlo", "initials": "L", "orcid": "0000-0002-4984-4058", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6751db52f71146f49325f9ae87377ca3.json"}}, {"family": "Gomez", "given": "Borja", "initials": "B", "orcid": "0000-0001-6542-4494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21a0b7480f814dc9b295d90064ff20df.json"}}, {"family": "Greber-Platzer", "given": "Susanne", "initials": "S", "orcid": "0000-0002-3706-8370", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a396b96cb774df8b0d7ee369bdf31a0.json"}}, {"family": "Guedj", "given": "Romain", "initials": "R"}, {"family": "Hartshorn", "given": "Stuart", "initials": "S", "orcid": "0000-0003-0419-1564", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd07611e3974424596f1c06a15b0c64f.json"}}, {"family": "Hey", "given": "Florian", "initials": "F", "orcid": "0000-0001-6183-5798", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40a5401c6a28450fa7739f459f5944cf.json"}}, {"family": "Jankauskaite", "given": "Lina", "initials": "L", "orcid": "0000-0002-6997-4917", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a66e27835a87452181c6d16d37d8a60d.json"}}, {"family": "Kohlfuerst", "given": "Daniela", "initials": "D", "orcid": "0000-0002-1188-9525", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c89a5b53f956492285bbd9eb41486dc4.json"}}, {"family": "Kolnik", "given": "Mojca", "initials": "M", "orcid": "0000-0003-4194-7295", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01ae84eef06542a69573bb235e792b2d.json"}}, {"family": "Lyttle", "given": "Mark D", "initials": "MD", "orcid": "0000-0002-8634-7210", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c196102c81b4abf843cdaed12fe1cd5.json"}}, {"family": "Ma\u00e7\u00e3o", "given": "Patr\u00edcia", "initials": "P"}, {"family": "Mascarenhas", "given": "Maria In\u00eas", "initials": "MI"}, {"family": "Messahel", "given": "Shrouk", "initials": "S", "orcid": "0000-0003-0645-3070", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2654e67acf45429f9c86751a25e1918c.json"}}, {"family": "\u00d6zkan", "given": "Esra Aky\u00fcz", "initials": "EA"}, {"family": "Pu\u010duka", "given": "Zanda", "initials": "Z", "orcid": "0000-0002-6070-3563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1eb4a8297132442aaccf4bf4f7541407.json"}}, {"family": "Reis", "given": "Sofia", "initials": "S"}, {"family": "Rybak", "given": "Alexis", "initials": "A", "orcid": "0000-0002-2898-3710", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eca3664e52894d278a9b8e58d8bd7572.json"}}, {"family": "Ryd Rinder", "given": "Malin", "initials": "M", "orcid": "0000-0002-2947-4117", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b87e79413e84d8bb0a71a16fa3975fc.json"}}, {"family": "Teksam", "given": "Ozlem", "initials": "O"}, {"family": "Turan", "given": "Caner", "initials": "C", "orcid": "0000-0001-9469-5162", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e60e2d771749443283698d7c9c68bbc4.json"}}, {"family": "Thors", "given": "Valt\u00fdr Stef\u00e1nsson", "initials": "VS", "orcid": "0000-0002-0976-9604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe040ce0586f4aa69a84c26a4e58c0bd.json"}}, {"family": "Velasco", "given": "Roberto", "initials": "R", "orcid": "0000-0003-0073-2650", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/492e63741600403ea7a19017f167b203.json"}}, {"family": "Bressan", "given": "Silvia", "initials": "S"}, {"family": "Moll", "given": "Henriette A", "initials": "HA", "orcid": "0000-0001-9304-3322", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ef2448fc7e34cb3bce7b402eb9852cf.json"}}, {"family": "Oostenbrink", "given": "Rianne", "initials": "R", "orcid": "0000-0001-7919-8934", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3902bdbd1604b67b1b29c8ef8890323.json"}}, {"family": "Titomanlio", "given": "Luigi", "initials": "L", "orcid": "0000-0003-4909-803X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b9f5485226f4651afe8e9fa3594cf94.json"}}, {"family": "in association with the REPEM network (Research in European Pediatric Emergency Medicine) as part of the EPISODES study group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-08-26", "journal": {"title": "PLoS Med", "issn": "1549-1676", "volume": "19", "issue": "8", "pages": "e1003974", "issn-l": "1549-1277"}, "abstract": "During the initial phase of the Coronavirus Disease 2019 (COVID-19) pandemic, reduced numbers of acutely ill or injured children presented to emergency departments (EDs). Concerns were raised about the potential for delayed and more severe presentations and an increase in diagnoses such as diabetic ketoacidosis and mental health issues. This multinational observational study aimed to study the number of children presenting to EDs across Europe during the early COVID-19 pandemic and factors influencing this and to investigate changes in severity of illness and diagnoses.\n\nRoutine health data were extracted retrospectively from electronic patient records of children aged 18 years and under, presenting to 38 EDs in 16 European countries for the period January 2018 to May 2020, using predefined and standardized data domains. Observed and predicted numbers of ED attendances were calculated for the period February 2020 to May 2020. Poisson models and incidence rate ratios (IRRs), using predicted counts for each site as offset to adjust for case-mix differences, were used to compare age groups, diagnoses, and outcomes. Reductions in pediatric ED attendances, hospital admissions, and high triage urgencies were seen in all participating sites. ED attendances were relatively higher in countries with lower SARS-CoV-2 prevalence (IRR 2\u00b726, 95% CI 1\u00b790 to 2\u00b770, p < 0.001) and in children aged <12 months (12 to <24 months IRR 0\u00b786, 95% CI 0\u00b784 to 0\u00b789; 2 to <5 years IRR 0\u00b780, 95% CI 0\u00b778 to 0\u00b782; 5 to <12 years IRR 0\u00b768, 95% CI 0\u00b767 to 0\u00b770; 12 to 18 years IRR 0\u00b772, 95% CI 0\u00b770 to 0\u00b774; versus age <12 months as reference group, p < 0.001). The lowering of pediatric intensive care admissions was not as great as that of general admissions (IRR 1\u00b730, 95% CI 1\u00b716 to 1\u00b745, p < 0.001). Lower triage urgencies were reduced more than higher triage urgencies (urgent triage IRR 1\u00b710, 95% CI 1\u00b708 to 1\u00b712; emergent and very urgent triage IRR 1\u00b753, 95% CI 1\u00b749 to 1\u00b757; versus nonurgent triage category, p < 0.001). Reductions were highest and sustained throughout the study period for children with communicable infectious diseases. The main limitation was the retrospective nature of the study, using routine clinical data from a wide range of European hospitals and health systems.\n\nReductions in ED attendances were seen across Europe during the first COVID-19 lockdown period. More severely ill children continued to attend hospital more frequently compared to those with minor injuries and illnesses, although absolute numbers fell.\n\nISRCTN91495258 https://www.isrctn.com/ISRCTN91495258.", "doi": "10.1371/journal.pmed.1003974", "pmid": "36026507", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PMEDICINE-D-22-00899"}], "notes": [], "created": "2022-09-12T19:15:08.788Z", "modified": "2022-09-12T19:15:09.744Z"}, {"entity": "publication", "iuid": "019dcb91399048119825bcefe2415ec4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/019dcb91399048119825bcefe2415ec4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/019dcb91399048119825bcefe2415ec4"}}, "title": "Face mask use during the COVID-19 pandemic: how risk perception, experience with COVID-19, and attitude towards government interact with country-wide policy stringency.", "authors": [{"family": "Wismans", "given": "Annelot", "initials": "A"}, {"family": "van der Zwan", "given": "Peter", "initials": "P"}, {"family": "Wennberg", "given": "Karl", "initials": "K"}, {"family": "Franken", "given": "Ingmar", "initials": "I"}, {"family": "Mukerjee", "given": "Jinia", "initials": "J"}, {"family": "Baptista", "given": "Rui", "initials": "R"}, {"family": "Mar\u00edn", "given": "Jorge Barrientos", "initials": "JB"}, {"family": "Burke", "given": "Andrew", "initials": "A"}, {"family": "Dejardin", "given": "Marcus", "initials": "M"}, {"family": "Janssen", "given": "Frank", "initials": "F"}, {"family": "Letina", "given": "Srebrenka", "initials": "S"}, {"family": "Mill\u00e1n", "given": "Jos\u00e9 Mar\u00eda", "initials": "JM"}, {"family": "Santarelli", "given": "Enrico", "initials": "E"}, {"family": "Torr\u00e8s", "given": "Olivier", "initials": "O"}, {"family": "Thurik", "given": "Roy", "initials": "R"}], "type": "journal article", "published": "2022-08-26", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "1622", "issn-l": null}, "abstract": "During the 2020 COVID-19 pandemic, governments imposed numerous regulations to protect public health, particularly the (mandatory) use of face masks. However, the appropriateness and effectiveness of face mask regulations have been widely discussed, as is apparent from the divergent measures taken across and within countries over time, including mandating, recommending, and discouraging their use. In this study, we analyse how country-level policy stringency and individual-level predictors associate with face mask use during the early stages of the global COVID-19 pandemic.\n\nFirst, we study how (self and other-related) risk perception, (direct and indirect) experience with COVID-19, attitude towards government and policy stringency shape face mask use. Second, we study whether there is an interaction between policy stringency and the individual-level variables. We conduct multilevel analyses exploiting variation in face mask regulations across countries and using data from approximately 7000 students collected in the beginning of the pandemic (weeks 17 through 19, 2020).\n\nWe show that policy stringency is strongly positively associated with face mask use. We find a positive association between self-related risk perception and mask use, but no relationship of mask use with experience with COVID-19 and attitudes towards government. However, in the interaction analyses, we find that government trust and perceived clarity of communication moderate the link between stringency and mask use, with positive government perceptions relating to higher use in countries with regulations and to lower use in countries without regulations.\n\nWe highlight that those countries that aim for widespread use of face masks should set strict measures, stress self-related risks of COVID-19, and use clear communication.", "doi": "10.1186/s12889-022-13632-9", "pmid": "36028876", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-022-13632-9"}, {"db": "pmc", "key": "PMC9412789"}], "notes": [], "created": "2022-10-07T12:37:59.851Z", "modified": "2022-10-07T12:39:28.164Z"}, {"entity": "publication", "iuid": "178091f103d9489385c75bfcc5e42ed3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/178091f103d9489385c75bfcc5e42ed3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/178091f103d9489385c75bfcc5e42ed3"}}, "title": "Call for a unified approach to Monkeypox infection in pregnancy: Lessons from the COVID-19 pandemic.", "authors": [{"family": "Khalil", "given": "Asma", "initials": "A", "orcid": "0000-0003-2802-7670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e4558e368114cfb83c4594f523b38c0.json"}}, {"family": "Samara", "given": "Athina", "initials": "A", "orcid": "0000-0001-6931-1972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ef0cd4edca4b2a837d2b275da0be56.json"}}, {"family": "O'Brien", "given": "Pat", "initials": "P"}, {"family": "Ladhani", "given": "Shamez", "initials": "S"}], "type": "journal article", "published": "2022-08-26", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "5038", "issn-l": "2041-1723"}, "abstract": null, "doi": "10.1038/s41467-022-32638-w", "pmid": "36028491", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-022-32638-w"}, {"db": "pmc", "key": "PMC9412782"}], "notes": [], "created": "2022-10-07T12:37:23.211Z", "modified": "2022-10-07T12:37:35.174Z"}, {"entity": "publication", "iuid": "fb18b1397aad4f3c80a2af8860e8d27c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb18b1397aad4f3c80a2af8860e8d27c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb18b1397aad4f3c80a2af8860e8d27c"}}, "title": "Relatives' perspectives on encounters and communication in nursing homes during the Covid-19 pandemic: a qualitative interview study.", "authors": [{"family": "Eriksson", "given": "Elisabet", "initials": "E"}, {"family": "Hjelm", "given": "Katarina", "initials": "K"}], "type": "journal article", "published": "2022-08-25", "journal": {"title": "BMC Geriatr", "issn": "1471-2318", "volume": "22", "issue": "1", "pages": "706", "issn-l": null}, "abstract": "Relatives of nursing home (NH) residents have experienced national or local restrictions on visiting their elderly family member during the Covid-19 pandemic. Today, many NHs have a multicultural environment, as staff, residents and their relatives speak different languages. Thus far, studies of remote communication with staff with limited language skills during the Covid-19 pandemic are lacking.\n\nThe aim of the present study was to explore relatives' experiences of encounters and communication with staff and residents in NHs during the Covid-19 pandemic.\n\nAn explorative qualitative study using semi-structured telephone interviews with 17 relatives of NH residents (12 women and 5 men). Data were analyzed using qualitative content analysis to identify four main categories and nine sub-categories.\n\nCommunicating during visiting restrictions was challenging, and relatives experienced ups and downs when trying to stay in contact with NH residents and staff. Relatives received general information, but desired information about residents' everyday life without having to ask for it. Moreover, remote communication was difficult for residents with hearing impairment or dementia. Even relatives who understood different languages had to develop strategies to communicate with staff with limited language skills in Swedish and English. Relatives did not mention using translating applications to facilitate communication.\n\nDuring visiting restrictions, relatives lacked information about residents' everyday life and found communication with staff with limited language skills challenging. For this reason, and to enable communication with staff with limited language skills, there is a need to find practical and technical solutions for facilitating remote communication between relatives, residents and staff at NHs.", "doi": "10.1186/s12877-022-03364-1", "pmid": "36008775", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12877-022-03364-1"}, {"db": "pmc", "key": "PMC9409621"}], "notes": [], "created": "2022-09-12T19:08:33.469Z", "modified": "2022-09-12T19:08:33.475Z"}, {"entity": "publication", "iuid": "4b584f3911754e1a8a9dcdc1f132a940", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b584f3911754e1a8a9dcdc1f132a940.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b584f3911754e1a8a9dcdc1f132a940"}}, "title": "Global safety monitoring of COVID-19 vaccines: how pharmacovigilance rose to the challenge.", "authors": [{"family": "Rudolph", "given": "Annette", "initials": "A", "orcid": "0000-0003-2360-7174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5f0f8bf831a4539b0b7939d8a68ce73.json"}}, {"family": "Mitchell", "given": "Joseph", "initials": "J"}, {"family": "Barrett", "given": "Jim", "initials": "J"}, {"family": "Sk\u00f6ld", "given": "Helena", "initials": "H"}, {"family": "Taavola", "given": "Henric", "initials": "H"}, {"family": "Erlanson", "given": "Nils", "initials": "N"}, {"family": "Melgarejo-Gonz\u00e1lez", "given": "Carlos", "initials": "C"}, {"family": "Yue", "given": "Qun-Ying", "initials": "QY"}], "type": "journal article", "published": "2022-08-25", "journal": {"title": "Ther Adv Drug Saf", "issn": "2042-0986", "volume": "13", "pages": "20420986221118972", "issn-l": null}, "abstract": "Pharmacovigilance (PV) came suddenly into the spotlight when several new vaccines, developed as a response to the COVID-19 pandemic, received emergency authorisation and were rolled out on a large scale in late 2020. The vaccines underwent stringent clinical trials and evaluation from regulatory authorities, but with the use of novel technology and an anticipated rapid and vast deployment of the vaccines, the importance of a well-functioning international post marketing safety surveillance system was stressed. International PV stakeholders were faced with several challenges due to the extent of the global vaccination campaign. The unprecedented volume of reports of suspected adverse events following immunization has led to the development and use of new tools. Furthermore, the collaboration between various PV stakeholders was encouraged and strengthened. PV rose to the challenges posed by the currently ongoing global COVID-19 vaccination campaign and successful adaptations were made in a short period of time. However, the pandemic has not ended yet, the vaccination campaign is far from being completed, and further challenges are anticipated. Advances made during the pandemic will be important to strengthen PV in future and ensure to advance medicines' safety together.\n\nGlobal safety monitoring of the COVID-19 vaccines: challenges, preparations, and outlooks Pharmacovigilance (PV) is the umbrella term for all sciences and activities relating to the detection, assessment, understanding, and prevention of adverse effects relating to medicines or vaccines. PV came into the spotlight when several new vaccines were authorised and rolled out as a response to the COVID-19 pandemic.The anticipated extent of the global vaccine rollout stressed the importance of a well-functioning safety surveillance system and international collaborations between patients, health care workers, vaccine producers, regulatory authorities, and PV centres.The identification and communication of potential safety concerns showed that adaptations to PV processes made in a short period of time as well as international collaborations were successful. However, it is important to learn from experiences made so far and to make sure the positive advances are maintained in the future to advance medicines' safety together.", "doi": "10.1177/20420986221118972", "pmid": "36052399", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1177_20420986221118972"}, {"db": "pmc", "key": "PMC9424876"}], "notes": [], "created": "2022-10-13T13:19:14.175Z", "modified": "2022-10-13T13:19:40.906Z"}, {"entity": "publication", "iuid": "e069bf0f7d774e09ba6cec9630efdec7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e069bf0f7d774e09ba6cec9630efdec7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e069bf0f7d774e09ba6cec9630efdec7"}}, "title": "Testing for coronarvirus disease 2019 before cardiac surgery-safe outcome of infected patients.", "authors": [{"family": "Ivert", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Dal\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2022-08-24", "journal": {"title": "J Cardiothorac Surg", "issn": "1749-8090", "volume": "17", "issue": "1", "pages": "201", "issn-l": null}, "abstract": "The aim was to analyze routine preoperative testing for coronavirus disease 2019 (COVID-19) performed to avoid infected cardiac surgical patients transmitting virus during the pandemic.\n\nEvery patient scheduled to undergo cardiac surgery from March 2020 through December 2021 had preoperative polymerase-chain-reaction (PCR) test for COVID-19 by nasopharynx swabs. Any history of COVID-19 was recorded.\n\nIn 15 of 1870 patients (0.8%) with minimal or no airway symptoms unexpected positive PCR tests were detected, and surgery was deferred for two weeks. Totally 38 patients with negative tests had recovered without sequelae from previous COVID-19 a mean of 5 months before the operation. Sixteen patients (0.8%) developed airway symptoms within six weeks after the operation and had positive COVID-19 tests. Body Mass Index was higher and female gender, diabetes mellitus, chronic obstructive pulmonary disease and reduced left ventricular ejection fraction were more common in patients with than in those without COVID-19. Early postoperative outcomes did not differ significantly in patients with versus without COVID-19.\n\nAn unexpected preoperative positive COVID-19 test was detected in less than one percent of patients admitted for cardiac surgery during the pandemic. These operations were deferred to avoid transmission of virus in the hospital. Additionally, one percent of patients were diagnosed with positive COVID-19 tests within six weeks after the operation. There was no outbreak of COVID-19 among hospital staff or patients. All patients with COVID-19 before the operation were operated on safely and postoperative outcomes did not differ significantly compared with COVID-19 negative patients.", "doi": "10.1186/s13019-022-01960-1", "pmid": "36002897", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13019-022-01960-1"}], "notes": [], "created": "2022-08-26T04:43:06.006Z", "modified": "2022-08-26T04:43:07.222Z"}, {"entity": "publication", "iuid": "73c368a02dd448df81ac0b2d0060c6a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/73c368a02dd448df81ac0b2d0060c6a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/73c368a02dd448df81ac0b2d0060c6a1"}}, "title": "Experienced stigma and applied coping strategies during the COVID-19 pandemic in Germany: a mixed-methods study.", "authors": [{"family": "Peters", "given": "Lynn", "initials": "L", "orcid": "0000-0003-4882-6816", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ba436f73aa94aebad063825bea44f30.json"}}, {"family": "Burkert", "given": "Sanne", "initials": "S", "orcid": "0000-0002-9961-4170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/117c68feabcf4bc283cd0b542ea022f2.json"}}, {"family": "Brenner", "given": "Cecilia", "initials": "C"}, {"family": "Gr\u00fcner", "given": "Beate", "initials": "B", "orcid": "0000-0001-6669-3741", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c573876e2e9470badfe5d2b7498ac17.json"}}], "type": "journal article", "published": "2022-08-24", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "8", "pages": "e059472", "issn-l": "2044-6055"}, "abstract": "Health-related stigma is considered a social determinant of health equity and a hidden burden of disease. This study aimed to assess the level and dimensions of stigma and respective coping mechanisms in COVID-19 survivors.\n\nA mixed-methods study with sequential explanatory design was conducted at the University Hospital of Ulm, Germany. Stigma was assessed using the Social Impact Scale (SIS) including adult COVID-19 survivors with mild-to-severe disease. Subsequently, 14 participants were sampled with regard to gender, age and severity of disease for in-depth interviews to understand how stigma was experienced and coping strategies were applied. The questionnaire was analysed using descriptive statistics, t-test and analysis of variance. Content analysis was used for qualitative data.\n\nFrom 61 participants, 58% were men and mean age was 51 years. The quantitative analysis of the SIS indicated an intermediate level of experienced stigma. Participants experienced stigma mainly as 'social rejection' (M=14.22, SD=4.91), followed by 'social isolation' (M=10.17, SD=4.16) and 'internalised shame' (M=8.39, SD=3.32). There was no significant difference in experienced stigma regarding gender, education, occupational status or residual symptoms. However, participants between 30 and 39 years of age experienced higher levels of stigma than other age groups (p=0.034). The qualitative analysis revealed how stigma seemed to arise from misconceptions creating irrational fear of infection, leading to stereotyping, vilification, discrimination and social exclusion of COVID-19 survivors, leaving them feeling vulnerable. Stigma cut through all social levels, from the individual level at the bottom to the institutional and societal level at the top. Social networks protected from experiencing stigma.\n\nCOVID-19-related stigma is a relevant burden in the ongoing pandemic. Providing accurate information and exposing misinformation on disease prevention and treatment seems key to end COVID-19-related stigma.", "doi": "10.1136/bmjopen-2021-059472", "pmid": "36002206", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-059472"}], "notes": [], "created": "2022-08-26T04:43:29.779Z", "modified": "2022-08-26T04:43:29.903Z"}, {"entity": "publication", "iuid": "0c379fbf9ff74982b51c247c9d641a4b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c379fbf9ff74982b51c247c9d641a4b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c379fbf9ff74982b51c247c9d641a4b"}}, "title": "Characteristics and Outcomes of People With Gout Hospitalized Due to COVID-19: Data From the COVID-19 Global Rheumatology Alliance Physician-Reported Registry.", "authors": [{"family": "Jatuworapruk", "given": "Kanon", "initials": "K", "orcid": "0000-0002-9301-8941", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98c57555175a45dcae2058d1986dca81.json"}}, {"family": "Montgomery", "given": "Anna", "initials": "A", "orcid": "0000-0003-3333-7833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6be3cbe46a3b4190a31e190c195f7e77.json"}}, {"family": "Gianfrancesco", "given": "Milena", "initials": "M", "orcid": "0000-0002-8351-4626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dca9cada1314065ab094be6fc17524e.json"}}, {"family": "Conway", "given": "Richard", "initials": "R", "orcid": "0000-0003-2538-3362", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77fe264e6d0d4c87b734f3fa02e42c15.json"}}, {"family": "Durcan", "given": "Laura", "initials": "L", "orcid": "0000-0001-6585-2974", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/287c2710c1124f318c1c48f939654110.json"}}, {"family": "Graef", "given": "Elizabeth R", "initials": "ER", "orcid": "0000-0001-5973-3477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a80ffebe8ad44d34b27689cd1a699229.json"}}, {"family": "Jayatilleke", "given": "Aruni", "initials": "A", "orcid": "0000-0003-0875-4280", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a87e2f22a51b4e5c9300063078169b8a.json"}}, {"family": "Keen", "given": "Helen", "initials": "H", "orcid": "0000-0002-8469-2424", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fc442133e9f4dda9baa0b83d732ce63.json"}}, {"family": "Kilian", "given": "Adam", "initials": "A", "orcid": "0000-0002-5710-7859", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b5228c807444dce92cb2bf0ab3106b3.json"}}, {"family": "Young", "given": "Kristen", "initials": "K", "orcid": "0000-0001-8570-2228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a27d6eed12724bb6ab180caab8fb1c49.json"}}, {"family": "Carmona", "given": "Loreto", "initials": "L", "orcid": "0000-0002-4401-2551", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/798721bfd6a14e2f95267a56c5750ebe.json"}}, {"family": "Cogo", "given": "Adriana Karina", "initials": "AK", "orcid": "0000-0002-9172-8317", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b41c8b74eb548259e966d268c88ce34.json"}}, {"family": "Duarte-Garc\u00eda", "given": "Al\u00ed", "initials": "A", "orcid": "0000-0003-1749-5719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77a5555c1b624ba49ee7c729be2aef95.json"}}, {"family": "Gossec", "given": "Laure", "initials": "L", "orcid": "0000-0002-4528-310X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be93914dbc9b4abb936cbcaf202de05f.json"}}, {"family": "Hasseli", "given": "Rebecca", "initials": "R", "orcid": "0000-0002-2982-8253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aac4e1f1ceab4e72bb816a40c2f80c44.json"}}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL", "orcid": "0000-0001-8242-9262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9ad49b088eb467ba6d1ca1559b88047.json"}}, {"family": "Langlois", "given": "Vincent", "initials": "V", "orcid": "0000-0002-4078-6306", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c85cfd8a1a5f45d5a73aa4c265493431.json"}}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S", "orcid": "0000-0002-8611-162X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73b17eb08d984421847f733b7a6a49d4.json"}}, {"family": "Malcata", "given": "Armando", "initials": "A"}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Schafer", "given": "Martin", "initials": "M", "orcid": "0000-0001-6487-3634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb2c617a7902440eb574fcb1141785ac.json"}}, {"family": "Scir\u00e8", "given": "Carlo Alberto", "initials": "CA", "orcid": "0000-0001-7451-0271", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76ebc6c1acb94b2780a38dc4e8aea708.json"}}, {"family": "Sigurdardottir", "given": "Valgerdur", "initials": "V", "orcid": "0000-0002-9907-4901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a451adf9d32f47b09bee7c8ed0eb22ab.json"}}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA", "orcid": "0000-0002-5556-4618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/192552e5e3d2435799e57111ea84502d.json"}}, {"family": "Strangfeld", "given": "Anja", "initials": "A"}, {"family": "Xavier", "given": "Ricardo M", "initials": "RM", "orcid": "0000-0001-6570-4533", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8c4f81afb3d469cb1a6bc19c42fd9e0.json"}}, {"family": "Bhana", "given": "Suleman", "initials": "S", "orcid": "0000-0003-3805-0946", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d9785cdfa2c4e99ae10bfd9b042be46.json"}}, {"family": "Gore-Massy", "given": "Monique", "initials": "M"}, {"family": "Hausmann", "given": "Jonathan", "initials": "J", "orcid": "0000-0003-0786-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d99dc166f48d4af7b8e46dc999c7444b.json"}}, {"family": "Liew", "given": "Jean W", "initials": "JW", "orcid": "0000-0002-8104-2450", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8099c4a02b6e4c4789fc9e6895abfb01.json"}}, {"family": "Sirotich", "given": "Emily", "initials": "E", "orcid": "0000-0002-7087-8543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c5dfbc359844544aa3684d916185fac.json"}}, {"family": "Sufka", "given": "Paul", "initials": "P", "orcid": "0000-0003-3131-7919", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/164a147aef724296ae7987d6b230c31c.json"}}, {"family": "Wallace", "given": "Zach", "initials": "Z", "orcid": "0000-0003-4708-7038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4cf68e5aa1444f8c8f8164fd0493a850.json"}}, {"family": "Machado", "given": "Pedro M", "initials": "PM", "orcid": "0000-0002-8411-7972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef40d1eea57946e4a37d2e92a02a47cd.json"}}, {"family": "Yazdany", "given": "Jinoos", "initials": "J", "orcid": "0000-0002-3508-4094", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62bbeb3392ce40d482da768af63f5d54.json"}}, {"family": "Grainger", "given": "Rebecca", "initials": "R", "orcid": "0000-0001-9201-8678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9d304e9e29a43a5a7a76679c002a876.json"}}, {"family": "Robinson", "given": "Philip C", "initials": "PC", "orcid": "0000-0002-3156-3418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/950b622d31724172817ccde09902d215.json"}}], "type": "journal article", "published": "2022-08-24", "journal": {"title": "ACR Open Rheumatol", "issn": "2578-5745", "issn-l": null}, "abstract": "To describe people with gout who were diagnosed with coronavirus disease 2019 (COVID-19) and hospitalized and to characterize their outcomes.\n\nData on patients with gout hospitalized for COVID-19 between March 12, 2020, and October 25, 2021, were extracted from the COVID-19 Global Rheumatology Alliance registry. Descriptive statistics were used to describe the demographics, comorbidities, medication exposures, and COVID-19 outcomes including oxygenation or ventilation support and death.\n\nOne hundred sixty-three patients with gout who developed COVID-19 and were hospitalized were included. The mean age was 63 years, and 85% were male. The majority of the group lived in the Western Pacific Region (35%) and North America (18%). Nearly half (46%) had two or more comorbidities, with hypertension (56%), cardiovascular disease (28%), diabetes mellitus (26%), chronic kidney disease (25%), and obesity (23%) being the most common. Glucocorticoids and colchicine were used pre-COVID-19 in 11% and 12% of the cohort, respectively. Over two thirds (68%) of the cohort required supplemental oxygen or ventilatory support during hospitalization. COVID-19-related death was reported in 16% of the overall cohort, with 73% of deaths documented in people with two or more comorbidities.\n\nThis cohort of people with gout and COVID-19 who were hospitalized had high frequencies of ventilatory support and death. This suggests that patients with gout who were hospitalized for COVID-19 may be at risk of poor outcomes, perhaps related to known risk factors for poor outcomes, such as age and presence of comorbidity.", "doi": "10.1002/acr2.11495", "pmid": "36000538", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-26T04:43:49.533Z", "modified": "2022-08-26T04:43:50.160Z"}, {"entity": "publication", "iuid": "41327e2709a34ff8b1b94bc0e9185e82", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41327e2709a34ff8b1b94bc0e9185e82.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41327e2709a34ff8b1b94bc0e9185e82"}}, "title": "Respiratory and systemic monocytes, dendritic cells and myeloid-derived suppressor cells in COVID-19: Implications for disease severity.", "authors": [{"family": "Falck-Jones", "given": "Sara", "initials": "S"}, {"family": "\u00d6sterberg", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A", "orcid": "0000-0001-6966-7039", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0c96bf27aca45f6b460a555c5425e2d.json"}}], "type": "journal article", "published": "2022-08-23", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null}, "abstract": "Since the beginning of the SARS-CoV-2 pandemic in 2020, researchers worldwide have made efforts to understand the mechanisms behind the varying range of COVID-19 disease severity. Since the respiratory tract is the site of infection, and immune cells differ depending on their anatomical location, studying blood is not sufficient to understand the full immunopathogenesis in patients with COVID-19. It is becoming increasingly clear that monocytes, dendritic cells (DCs) and monocytic myeloid-derived suppressor cells (M-MDSCs) are involved in the immunopathology of COVID-19 and may play important roles in determining disease severity. Patients with mild COVID-19 display an early antiviral (interferon) response in the nasopharynx, expansion of activated intermediate monocytes and low levels of M-MDSCs in blood. In contrast, patients with severe COVID-19 seem to lack an early efficient induction of interferons, and skew towards a more suppressive response in blood. This is characterized by downregulation of activation markers and decreased functional capacity of blood monocytes and DCs, reduced circulating DCs and increased levels of HLA-DRlo CD14+ M-MDSCs. These suppressive characteristics could potentially contribute to delayed T cell responses in severe COVID-19 cases. In contrast, airways of patients with severe COVID-19 display hyperinflammation with elevated levels of inflammatory monocytes and monocyte-derived macrophages, and reduced levels of tissue-resident alveolar macrophages. These monocyte-derived cells contribute to excess inflammation by producing cytokines and chemokines. Here, we review the current knowledge on the role of monocytes, DCs and M-MDSCs in COVID-19 and how alterations and the anatomical distribution of these cell populations may relate to disease severity. This article is protected by copyright. All rights reserved.", "doi": "10.1111/joim.13559", "pmid": "35996885", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2022-08-26T04:45:51.973Z", "modified": "2022-08-26T04:45:52.027Z"}, {"entity": "publication", "iuid": "ef5efbb16ed3439d97267aef0736031a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef5efbb16ed3439d97267aef0736031a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef5efbb16ed3439d97267aef0736031a"}}, "title": "Genetic predispositions to psychiatric disorders and the risk of COVID-19.", "authors": [{"family": "Chen", "given": "Wenwen", "initials": "W"}, {"family": "Zeng", "given": "Yu", "initials": "Y"}, {"family": "Suo", "given": "Chen", "initials": "C"}, {"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Chen", "given": "Yilong", "initials": "Y"}, {"family": "Hou", "given": "Can", "initials": "C"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "Sun", "given": "Yajing", "initials": "Y"}, {"family": "Qu", "given": "Yuanyuan", "initials": "Y"}, {"family": "Lu", "given": "Donghao", "initials": "D"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Song", "given": "Huan", "initials": "H", "orcid": "0000-0003-3845-8079", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2e35902226b407487330fc6c7368759.json"}}], "type": "journal article", "published": "2022-08-23", "journal": {"title": "BMC Med", "issn": "1741-7015", "volume": "20", "issue": "1", "pages": "314", "issn-l": null}, "abstract": "Whether a genetic predisposition to psychiatric disorders is associated with coronavirus disease 2019 (COVID-19) is unknown.\n\nOur analytic sample consisted of 287,123 white British participants in UK Biobank who were alive on 31 January 2020. We performed a genome-wide association study (GWAS) analysis for each psychiatric disorder (substance misuse, depression, anxiety, psychotic disorder, and stress-related disorders) in a randomly selected half of the study population (\"base dataset\"). For the other half (\"target dataset\"), the polygenic risk score (PRS) was calculated as a proxy of individuals' genetic predisposition to a given psychiatric phenotype using discovered genetic variants from the base dataset. Ascertainment of COVID-19 was based on the Public Health England dataset, inpatient hospital data, or death registers in UK Biobank. COVID-19 cases from hospitalization records or death records were considered \"severe cases.\" The association between the PRS for psychiatric disorders and COVID-19 risk was examined using logistic regression. We also repeated PRS analyses based on publicly available GWAS summary statistics.\n\nA total of 143,562 participants (including 10,868 COVID-19 cases) were used for PRS analyses. A higher genetic predisposition to psychiatric disorders was associated with an increased risk of any COVID-19 and severe COVID-19. The adjusted odds ratio (OR) for any COVID-19 was 1.07 (95% confidence interval [CI] 1.02-1.13) and 1.06 (95% CI 1.01-1.11) among individuals with a high genetic risk (above the upper tertile of the PRS) for substance misuse and depression, respectively, compared with individuals with a low genetic risk (below the lower tertile). Slightly higher ORs were noted for severe COVID-19, and similar result patterns were obtained in analyses based on publicly available GWAS summary statistics.\n\nOur findings suggest a potential role of genetic factors in the observed phenotypic association between psychiatric disorders and COVID-19. Our data underscore the need for increased medical surveillance for this vulnerable population during the COVID-19 pandemic.", "doi": "10.1186/s12916-022-02520-z", "pmid": "35999565", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12916-022-02520-z"}], "notes": [], "created": "2022-08-26T04:44:51.899Z", "modified": "2022-08-26T04:44:51.929Z"}, {"entity": "publication", "iuid": "c9f20a46bf7a480c9d2cafe1fe5582e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9f20a46bf7a480c9d2cafe1fe5582e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9f20a46bf7a480c9d2cafe1fe5582e2"}}, "title": "Diffuse alveolar damage patterns reflect the immunological and molecular heterogeneity in fatal COVID-19.", "authors": [{"family": "Erjef\u00e4lt", "given": "Jonas S", "initials": "JS"}, {"family": "de Souza Xavier Costa", "given": "Nat\u00e1lia", "initials": "N"}, {"family": "J\u00f6nsson", "given": "Jimmie", "initials": "J"}, {"family": "Cozzolino", "given": "Olga", "initials": "O"}, {"family": "Dantas", "given": "Katia Cristina", "initials": "KC"}, {"family": "Clausson", "given": "Carl-Magnus", "initials": "CM"}, {"family": "Siddhuraj", "given": "Premkumar", "initials": "P"}, {"family": "Lind\u00f6", "given": "Caroline", "initials": "C"}, {"family": "Alyamani", "given": "Manar", "initials": "M"}, {"family": "Lombardi", "given": "Suzete Cleusa Ferreira Spina", "initials": "SCFS"}, {"family": "Mendroni J\u00fanior", "given": "Alfredo", "initials": "A"}, {"family": "Antonangelo", "given": "Leila", "initials": "L"}, {"family": "Faria", "given": "Caroline Silv\u00e9rio", "initials": "CS"}, {"family": "Duarte-Neto", "given": "Amaro Nunes", "initials": "AN"}, {"family": "de Almeida Monteiro", "given": "Renata Aparecida", "initials": "RA"}, {"family": "Rebello Pinho", "given": "Jo\u00e3o Renato", "initials": "JR"}, {"family": "Gomes-Gouv\u00eaa", "given": "Michele Soares", "initials": "MS"}, {"family": "Verciano Pereira", "given": "Roberta", "initials": "R"}, {"family": "Monteiro", "given": "Jhonatas Sirino", "initials": "JS"}, {"family": "Setubal", "given": "Jo\u00e3o Carlos", "initials": "JC"}, {"family": "de Oliveira", "given": "Ellen Pierre", "initials": "EP"}, {"family": "Theodoro Filho", "given": "Jair", "initials": "J"}, {"family": "Sanden", "given": "Caroline", "initials": "C"}, {"family": "Orengo", "given": "Jamie M", "initials": "JM"}, {"family": "Sleeman", "given": "Matthew A", "initials": "MA"}, {"family": "da Silva", "given": "Luiz Fernando Ferraz", "initials": "LFF"}, {"family": "Saldiva", "given": "Paulo Hil\u00e1rio Nascimento", "initials": "PHN"}, {"family": "Dolhnikoff", "given": "Marisa", "initials": "M"}, {"family": "Mauad", "given": "Thais", "initials": "T"}], "type": "journal article", "published": "2022-08-23", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "volume": "83", "pages": "104229", "issn-l": null}, "abstract": "Severe COVID-19 lung disease exhibits a high degree of spatial and temporal heterogeneity, with different histological features coexisting within a single individual. It is important to capture the disease complexity to support patient management and treatment strategies. We provide spatially decoded analyses on the immunopathology of diffuse alveolar damage (DAD) patterns and factors that modulate immune and structural changes in fatal COVID-19.\n\nWe spatially quantified the immune and structural cells in exudative, intermediate, and advanced DAD through multiplex immunohistochemistry in autopsy lung tissue of 18 COVID-19 patients. Cytokine profiling, viral, bacteria, and fungi detection, and transcriptome analyses were performed.\n\nSpatial DAD progression was associated with expansion of immune cells, macrophages, CD8+ T cells, fibroblasts, and (lymph)angiogenesis. Viral load correlated positively with exudative DAD and negatively with disease/hospital length. In all cases, enteric bacteria were isolated, and Candida parapsilosis in eight cases. Cytokines correlated mainly with macrophages and CD8+T cells. Pro-coagulation and acute repair were enriched pathways in exudative DAD whereas intermediate/advanced DAD had a molecular profile of elevated humoral and innate immune responses and extracellular matrix production.\n\nUnraveling the spatial and molecular immunopathology of COVID-19 cases exposes the responses to SARS-CoV-2-induced exudative DAD and subsequent immune-modulatory and remodeling changes in proliferative/advanced DAD that occur side-by-side together with secondary infections in the lungs. These complex features have important implications for disease management and the development of novel treatments.\n\nCNPq, Bill and Melinda Gates Foundation, HC-Convida, FAPESP, Regeneron Pharmaceuticals, and the Swedish Heart & Lung Foundation.", "doi": "10.1016/j.ebiom.2022.104229", "pmid": "36027872", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2352-3964(22)00411-X"}, {"db": "pmc", "key": "PMC9398470"}], "notes": [], "created": "2022-09-12T19:15:23.961Z", "modified": "2022-09-12T19:15:23.966Z"}, {"entity": "publication", "iuid": "d616ec14309e4023a914ce720f7f17c4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d616ec14309e4023a914ce720f7f17c4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d616ec14309e4023a914ce720f7f17c4"}}, "title": "Clinical risk factors of adverse outcomes among women with COVID-19 in the pregnancy and postpartum period: A sequential, prospective meta-analysis.", "authors": [{"family": "Smith", "given": "Emily R", "initials": "ER"}, {"family": "Oakley", "given": "Erin", "initials": "E"}, {"family": "Grandner", "given": "Gargi Wable", "initials": "GW"}, {"family": "Rukundo", "given": "Gordon", "initials": "G"}, {"family": "Farooq", "given": "Fouzia", "initials": "F"}, {"family": "Ferguson", "given": "Kacey", "initials": "K"}, {"family": "Baumann", "given": "Sasha", "initials": "S"}, {"family": "Waldorf", "given": "Kristina Adams", "initials": "KA"}, {"family": "Afshar", "given": "Yalda", "initials": "Y"}, {"family": "Ahlberg", "given": "Mia", "initials": "M"}, {"family": "Ahmadzia", "given": "Homa", "initials": "H"}, {"family": "Akelo", "given": "Victor", "initials": "V"}, {"family": "Aldrovandi", "given": "Grace", "initials": "G"}, {"family": "Bevilacqua", "given": "Elisa", "initials": "E"}, {"family": "Bracero", "given": "Nabal", "initials": "N"}, {"family": "Brandt", "given": "Justin S", "initials": "JS"}, {"family": "Broutet", "given": "Natalie", "initials": "N"}, {"family": "Carrillo", "given": "Jorge", "initials": "J"}, {"family": "Conry", "given": "Jeanne", "initials": "J"}, {"family": "Cosmi", "given": "Erich", "initials": "E"}, {"family": "Crispi", "given": "Fatima", "initials": "F"}, {"family": "Crovetto", "given": "Francesca", "initials": "F"}, {"family": "Gil", "given": "Maria Del Mar", "initials": "MDM"}, {"family": "Delgado-L\u00f3pez", "given": "Camille", "initials": "C"}, {"family": "Divakar", "given": "Hema", "initials": "H"}, {"family": "Driscoll", "given": "Amanda J", "initials": "AJ"}, {"family": "Favre", "given": "Guillaume", "initials": "G"}, {"family": "Buhigas", "given": "Irene Fernandez", "initials": "IF"}, {"family": "Flaherman", "given": "Valerie", "initials": "V"}, {"family": "Gale", "given": "Christopher", "initials": "C"}, {"family": "Godwin", "given": "Christine L", "initials": "CL"}, {"family": "Gottlieb", "given": "Sami", "initials": "S"}, {"family": "Gratac\u00f3s", "given": "Eduard", "initials": "E"}, {"family": "He", "given": "Siran", "initials": "S"}, {"family": "Hernandez", "given": "Olivia", "initials": "O"}, {"family": "Jones", "given": "Stephanie", "initials": "S"}, {"family": "Joshi", "given": "Sheetal", "initials": "S"}, {"family": "Kalafat", "given": "Erkan", "initials": "E"}, {"family": "Khagayi", "given": "Sammy", "initials": "S"}, {"family": "Knight", "given": "Marian", "initials": "M"}, {"family": "Kotloff", "given": "Karen", "initials": "K"}, {"family": "Lanzone", "given": "Antonio", "initials": "A"}, {"family": "Longo", "given": "Valentina Laurita", "initials": "VL"}, {"family": "Le Doare", "given": "Kirsty", "initials": "K"}, {"family": "Lees", "given": "Christoph", "initials": "C"}, {"family": "Litman", "given": "Ethan", "initials": "E"}, {"family": "Lokken", "given": "Erica M", "initials": "EM"}, {"family": "Madhi", "given": "Shabir A", "initials": "SA"}, {"family": "Magee", "given": "Laura A", "initials": "LA"}, {"family": "Martinez-Portilla", "given": "Raigam Jafet", "initials": "RJ"}, {"family": "Metz", "given": "Torri D", "initials": "TD"}, {"family": "Miller", "given": "Emily S", "initials": "ES"}, {"family": "Money", "given": "Deborah", "initials": "D"}, {"family": "Moungmaithong", "given": "Sakita", "initials": "S"}, {"family": "Mullins", "given": "Edward", "initials": "E"}, {"family": "Nachega", "given": "Jean B", "initials": "JB"}, {"family": "Nunes", "given": "Marta C", "initials": "MC"}, {"family": "Onyango", "given": "Dickens", "initials": "D"}, {"family": "Panchaud", "given": "Alice", "initials": "A"}, {"family": "Poon", "given": "Liona C", "initials": "LC"}, {"family": "Raiten", "given": "Daniel", "initials": "D"}, {"family": "Regan", "given": "Lesley", "initials": "L"}, {"family": "Sahota", "given": "Daljit", "initials": "D"}, {"family": "Sakowicz", "given": "Allie", "initials": "A"}, {"family": "Sanin-Blair", "given": "Jose", "initials": "J"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}, {"family": "Temmerman", "given": "Marleen", "initials": "M"}, {"family": "Thorson", "given": "Anna", "initials": "A"}, {"family": "Thwin", "given": "Soe Soe", "initials": "SS"}, {"family": "Tippett Barr", "given": "Beth A", "initials": "BA"}, {"family": "Tolosa", "given": "Jorge E", "initials": "JE"}, {"family": "Tug", "given": "Niyazi", "initials": "N"}, {"family": "Valencia-Prado", "given": "Miguel", "initials": "M"}, {"family": "Visentin", "given": "Silvia", "initials": "S"}, {"family": "von Dadelszen", "given": "Peter", "initials": "P"}, {"family": "Whitehead", "given": "Clare", "initials": "C"}, {"family": "Wood", "given": "Mollie", "initials": "M"}, {"family": "Yang", "given": "Huixia", "initials": "H"}, {"family": "Zavala", "given": "Rebecca", "initials": "R"}, {"family": "Tielsch", "given": "James M", "initials": "JM"}], "type": "journal article", "published": "2022-08-23", "journal": {"title": "Am J Obstet Gynecol", "issn": "1097-6868", "issn-l": null}, "abstract": "This sequential, prospective meta-analysis (sPMA) sought to identify risk factors among pregnant and postpartum women with COVID-19 for adverse outcomes related to: disease severity, maternal morbidities, neonatal mortality and morbidity, adverse birth outcomes.\n\nWe prospectively invited study investigators to join the sPMA via professional research networks beginning in March 2020.\n\nEligible studies included those recruiting at least 25 consecutive cases of COVID-19 in pregnancy within a defined catchment area.\n\nWe included individual patient data from 21 participating studies. Data quality was assessed, and harmonized variables for risk factors and outcomes were constructed. Duplicate cases were removed. Pooled estimates for the absolute and relative risk of adverse outcomes comparing those with and without each risk factor were generated using a two-stage meta-analysis.\n\nWe collected data from 33 countries and territories, including 21,977 cases of SARS-CoV-2 infection in pregnancy or postpartum. We found that women with comorbidities (pre-existing diabetes, hypertension, cardiovascular disease) versus those without were at higher risk for COVID-19 severity and pregnancy health outcomes (fetal death, preterm birth, low birthweight). Participants with COVID-19 and HIV were 1.74 times (95% CI: 1.12, 2.71) more likely to be admitted to the ICU. Pregnant women who were underweight before pregnancy were at higher risk of ICU admission (RR 5.53, 95% CI: 2.27, 13.44), ventilation (RR 9.36, 95% CI: 3.87, 22.63), and pregnancy-related death (RR 14.10, 95% CI: 2.83, 70.36). Pre-pregnancy obesity was also a risk factor for severe COVID-19 outcomes including ICU admission (RR 1.81, 95% CI: 1.26,2.60), ventilation (RR 2.05, 95% CI: 1.20,3.51), any critical care (RR 1.89, 95% CI: 1.28,2.77), and pneumonia (RR 1.66, 95% CI: 1.18,2.33). Anemic pregnant women with COVID-19 also had increased risk of ICU admission (RR 1.63, 95% CI: 1.25, 2.11) and death (RR 2.36, 95% CI: 1.15, 4.81).\n\nWe found that pregnant women with comorbidities including diabetes, hypertension, and cardiovascular disease were at increased risk for severe COVID-19-related outcomes, maternal morbidities, and adverse birth outcomes. We also identified several less commonly-known risk factors, including HIV infection, pre-pregnancy underweight, and anemia. Although pregnant women are already considered a high-risk population, special priority for prevention and treatment should be given to pregnant women with these additional risk factors.", "doi": "10.1016/j.ajog.2022.08.038", "pmid": "36027953", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0002-9378(22)00680-9"}, {"db": "pmc", "key": "PMC9398561"}], "notes": [], "created": "2022-09-12T19:15:47.556Z", "modified": "2022-09-12T19:15:47.562Z"}, {"entity": "publication", "iuid": "255dd60f402c4f3da278ba0e771bd03f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/255dd60f402c4f3da278ba0e771bd03f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/255dd60f402c4f3da278ba0e771bd03f"}}, "title": "The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force.", "authors": [{"family": "Wang", "given": "Qingbo S", "initials": "QS"}, {"family": "Edahiro", "given": "Ryuya", "initials": "R"}, {"family": "Namkoong", "given": "Ho", "initials": "H"}, {"family": "Hasegawa", "given": "Takanori", "initials": "T"}, {"family": "Shirai", "given": "Yuya", "initials": "Y"}, {"family": "Sonehara", "given": "Kyuto", "initials": "K"}, {"family": "Tanaka", "given": "Hiromu", "initials": "H"}, {"family": "Lee", "given": "Ho", "initials": "H"}, {"family": "Saiki", "given": "Ryunosuke", "initials": "R", "orcid": "0000-0001-6984-7187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd5bae576b614b1f9e27c3975f2f72a2.json"}}, {"family": "Hyugaji", "given": "Takayoshi", "initials": "T"}, {"family": "Shimizu", "given": "Eigo", "initials": "E"}, {"family": "Katayama", "given": "Kotoe", "initials": "K", "orcid": "0000-0002-3966-1231", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68f93c3d200e45cea3eaea3a1758f0af.json"}}, {"family": "Kanai", "given": "Masahiro", "initials": "M", "orcid": "0000-0001-5165-4408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01d858a30cea453d91cedab1fd5c8494.json"}}, {"family": "Naito", "given": "Tatsuhiko", "initials": "T", "orcid": "0000-0002-2779-4600", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b0897a4c92b4ca781c81fc0d5520385.json"}}, {"family": "Sasa", "given": "Noah", "initials": "N"}, {"family": "Yamamoto", "given": "Kenichi", "initials": "K", "orcid": "0000-0001-9594-7050", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d494d739ff8469c9f6def67c94cb3ef.json"}}, {"family": "Kato", "given": "Yasuhiro", "initials": "Y"}, {"family": "Morita", "given": "Takayoshi", "initials": "T"}, {"family": "Takahashi", "given": "Kazuhisa", "initials": "K", "orcid": "0000-0001-5749-4118", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d5ac9fceb6f47ffabede76f02a183e4.json"}}, {"family": "Harada", "given": "Norihiro", "initials": "N"}, {"family": "Naito", "given": "Toshio", "initials": "T"}, {"family": "Hiki", "given": "Makoto", "initials": "M"}, {"family": "Matsushita", "given": "Yasushi", "initials": "Y"}, {"family": "Takagi", "given": "Haruhi", "initials": "H"}, {"family": "Ichikawa", "given": "Masako", "initials": "M"}, {"family": "Nakamura", "given": "Ai", "initials": "A"}, {"family": "Harada", "given": "Sonoko", "initials": "S"}, {"family": "Sandhu", "given": "Yuuki", "initials": "Y"}, {"family": "Kabata", "given": "Hiroki", "initials": "H"}, {"family": "Masaki", "given": "Katsunori", "initials": "K"}, {"family": "Kamata", "given": "Hirofumi", "initials": "H"}, {"family": "Ikemura", "given": "Shinnosuke", "initials": "S"}, {"family": "Chubachi", "given": "Shotaro", "initials": "S"}, {"family": "Okamori", "given": "Satoshi", "initials": "S"}, {"family": "Terai", "given": "Hideki", "initials": "H", "orcid": "0000-0002-1118-1930", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d4b3da553c9463a84199024fbe1c41b.json"}}, {"family": "Morita", "given": "Atsuho", "initials": "A"}, {"family": "Asakura", "given": "Takanori", "initials": "T", "orcid": "0000-0003-3122-6937", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2031e5d0b29849d6ba08e174e7da4834.json"}}, {"family": "Sasaki", "given": "Junichi", "initials": "J"}, {"family": "Morisaki", "given": "Hiroshi", "initials": "H"}, {"family": "Uwamino", "given": "Yoshifumi", "initials": "Y"}, {"family": "Nanki", "given": "Kosaku", "initials": "K"}, {"family": "Uchida", "given": "Sho", "initials": "S"}, {"family": "Uno", "given": "Shunsuke", "initials": "S"}, {"family": "Nishimura", "given": "Tomoyasu", "initials": "T"}, {"family": "Ishiguro", "given": "Takashri", "initials": "T"}, {"family": "Isono", "given": "Taisuke", "initials": "T"}, {"family": "Shibata", "given": "Shun", "initials": "S"}, {"family": "Matsui", "given": "Yuma", "initials": "Y"}, {"family": "Hosoda", "given": "Chiaki", "initials": "C"}, {"family": "Takano", "given": "Kenji", "initials": "K"}, {"family": "Nishida", "given": "Takashi", "initials": "T"}, {"family": "Kobayashi", "given": "Yoichi", "initials": "Y"}, {"family": "Takaku", "given": "Yotaro", "initials": "Y"}, {"family": "Takayanagi", "given": "Noboru", "initials": "N"}, {"family": "Ueda", "given": "Soichiro", "initials": "S"}, {"family": "Tada", "given": "Ai", "initials": "A"}, {"family": "Miyawaki", "given": "Masayoshi", "initials": "M"}, {"family": "Yamamoto", "given": "Masaomi", "initials": "M"}, {"family": "Yoshida", "given": "Eriko", "initials": "E"}, {"family": "Hayashi", "given": "Reina", "initials": "R"}, {"family": "Nagasaka", "given": "Tomoki", "initials": "T"}, {"family": "Arai", "given": "Sawako", "initials": "S"}, {"family": "Kaneko", "given": "Yutaro", "initials": "Y"}, {"family": "Sasaki", "given": "Kana", "initials": "K"}, {"family": "Tagaya", "given": "Etsuko", "initials": "E"}, {"family": "Kawana", "given": "Masatoshi", "initials": "M"}, {"family": "Arimura", "given": "Ken", "initials": "K"}, {"family": "Takahashi", "given": "Kunihiko", "initials": "K"}, {"family": "Anzai", "given": "Tatsuhiko", "initials": "T"}, {"family": "Ito", "given": "Satoshi", "initials": "S"}, {"family": "Endo", "given": "Akifumi", "initials": "A"}, {"family": "Uchimura", "given": "Yuji", "initials": "Y"}, {"family": "Miyazaki", "given": "Yasunari", "initials": "Y", "orcid": "0000-0002-9073-9815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cabd9b972ca24453957c822589b9bebd.json"}}, {"family": "Honda", "given": "Takayuki", "initials": "T"}, {"family": "Tateishi", "given": "Tomoya", "initials": "T"}, {"family": "Tohda", "given": "Shuji", "initials": "S"}, {"family": "Ichimura", "given": "Naoya", "initials": "N"}, {"family": "Sonobe", "given": "Kazunari", "initials": "K"}, {"family": "Sassa", "given": "Chihiro Tani", "initials": "CT"}, {"family": "Nakajima", "given": "Jun", "initials": "J"}, {"family": "Nakano", "given": "Yasushi", "initials": "Y"}, {"family": "Nakajima", "given": "Yukiko", "initials": "Y"}, {"family": "Anan", "given": "Ryusuke", "initials": "R"}, {"family": "Arai", "given": "Ryosuke", "initials": "R"}, {"family": "Kurihara", "given": "Yuko", "initials": "Y"}, {"family": "Harada", "given": "Yuko", "initials": "Y"}, {"family": "Nishio", "given": "Kazumi", "initials": "K"}, {"family": "Ueda", "given": "Tetsuya", "initials": "T"}, {"family": "Azuma", "given": "Masanori", "initials": "M"}, {"family": "Saito", "given": "Ryuichi", "initials": "R"}, {"family": "Sado", "given": "Toshikatsu", "initials": "T"}, {"family": "Miyazaki", "given": "Yoshimune", "initials": "Y"}, {"family": "Sato", "given": "Ryuichi", "initials": "R"}, {"family": "Haruta", "given": "Yuki", "initials": "Y"}, {"family": "Nagasaki", "given": "Tadao", "initials": "T"}, {"family": "Yasui", "given": "Yoshinori", "initials": "Y"}, {"family": "Hasegawa", "given": "Yoshinori", "initials": "Y"}, {"family": "Mutoh", "given": "Yoshikazu", "initials": "Y"}, {"family": "Kimura", "given": "Tomoki", "initials": "T"}, {"family": "Sato", "given": "Tomonori", "initials": "T"}, {"family": "Takei", "given": "Reoto", "initials": "R"}, {"family": "Hagimoto", "given": "Satoshi", "initials": "S"}, {"family": "Noguchi", "given": "Yoichiro", "initials": "Y"}, {"family": "Yamano", "given": "Yasuhiko", "initials": "Y"}, {"family": "Sasano", "given": "Hajime", "initials": "H"}, {"family": "Ota", "given": "Sho", "initials": "S"}, {"family": "Nakamori", "given": "Yasushi", "initials": "Y"}, {"family": "Yoshiya", "given": "Kazuhisa", "initials": "K"}, {"family": "Saito", "given": "Fukuki", "initials": "F"}, {"family": "Yoshihara", "given": "Tomoyuki", "initials": "T"}, {"family": "Wada", "given": "Daiki", "initials": "D"}, {"family": "Iwamura", "given": "Hiromu", "initials": "H"}, {"family": "Kanayama", "given": "Syuji", "initials": "S"}, {"family": "Maruyama", "given": "Shuhei", "initials": "S"}, {"family": "Yoshiyama", "given": "Takashi", "initials": "T"}, {"family": "Ohta", "given": "Ken", "initials": "K"}, {"family": "Kokuto", "given": "Hiroyuki", "initials": "H"}, {"family": "Ogata", "given": "Hideo", "initials": "H"}, {"family": "Tanaka", "given": "Yoshiaki", "initials": "Y"}, {"family": "Arakawa", "given": "Kenichi", "initials": "K"}, {"family": "Shimoda", "given": "Masafumi", "initials": "M"}, {"family": "Osawa", "given": "Takeshi", "initials": "T"}, {"family": "Tateno", "given": "Hiroki", "initials": "H"}, {"family": "Hase", "given": "Isano", "initials": "I"}, {"family": "Yoshida", "given": "Shuichi", "initials": "S"}, {"family": "Suzuki", "given": "Shoji", "initials": "S"}, {"family": "Kawada", "given": "Miki", "initials": "M"}, {"family": "Horinouchi", "given": "Hirohisa", "initials": "H"}, {"family": "Saito", "given": "Fumitake", "initials": "F"}, {"family": "Mitamura", "given": "Keiko", "initials": "K"}, {"family": "Hagihara", "given": "Masao", "initials": "M"}, {"family": "Ochi", "given": "Junichi", "initials": "J"}, {"family": "Uchida", "given": "Tomoyuki", "initials": "T"}, {"family": "Baba", "given": "Rie", "initials": "R"}, {"family": "Arai", "given": "Daisuke", "initials": "D"}, {"family": "Ogura", "given": "Takayuki", "initials": "T"}, {"family": "Takahashi", "given": "Hidenori", "initials": "H"}, {"family": "Hagiwara", "given": "Shigehiro", "initials": "S"}, {"family": "Nagao", "given": "Genta", "initials": "G"}, {"family": "Konishi", "given": "Shunichiro", "initials": "S"}, {"family": "Nakachi", "given": "Ichiro", "initials": "I"}, {"family": "Murakami", "given": "Koji", "initials": "K"}, {"family": "Yamada", "given": "Mitsuhiro", "initials": "M", "orcid": "0000-0002-0832-1939", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d3444abf3314d299e9273003635c06a.json"}}, {"family": "Sugiura", "given": "Hisatoshi", "initials": "H", "orcid": 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"researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34661820735e4853b72794b693577d25.json"}}, {"family": "Ishii", "given": "Makoto", "initials": "M", "orcid": "0000-0003-4396-1664", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/baeffc7d32584e36a16ccd0d1d39aeaa.json"}}, {"family": "Koike", "given": "Ryuji", "initials": "R"}, {"family": "Kitagawa", "given": "Yuko", "initials": "Y"}, {"family": "Kimura", "given": "Akinori", "initials": "A"}, {"family": "Imoto", "given": "Seiya", "initials": "S", "orcid": "0000-0002-2989-308X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f199938ef404db986b6697e05d41d56.json"}}, {"family": "Miyano", "given": "Satoru", "initials": "S"}, {"family": "Ogawa", "given": "Seishi", "initials": "S", "orcid": "0000-0002-7778-5374", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/794485862ba3443294803c120ae16e3a.json"}}, {"family": "Kanai", "given": "Takanori", "initials": "T", "orcid": "0000-0002-1466-4532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c701a687e494d90b9fc18a75a909a28.json"}}, {"family": "Fukunaga", "given": "Koichi", "initials": "K"}, {"family": "Okada", "given": "Yukinori", "initials": "Y", "orcid": "0000-0002-0311-8472", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/180d7682259f44da968366b41662b959.json"}}], "type": "journal article", "published": "2022-08-22", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "4830", "issn-l": "2041-1723"}, "abstract": "Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection.", "doi": "10.1038/s41467-022-32276-2", "pmid": "35995775", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-022-32276-2"}, {"db": "pmc", "key": "PMC9395416"}], "notes": [], "created": "2022-09-12T19:06:01.529Z", "modified": "2022-09-12T19:06:02.312Z"}, {"entity": "publication", "iuid": "ab648c6fe66743d389ec34b288e73dcb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ab648c6fe66743d389ec34b288e73dcb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ab648c6fe66743d389ec34b288e73dcb"}}, "title": "Cross-cultural equivalence of parental ratings of child difficulties during the pandemic: Findings from a six-site study.", "authors": [{"family": "Foley", "given": "Sarah", "initials": "S", "orcid": "0000-0001-8900-9885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2661df30ae94fc296211e848a02a0b9.json"}}, {"family": "Ronchi", "given": "Luca", "initials": "L", "orcid": "0000-0001-7723-9376", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1e89c62c76f443288c1df82f370cdf4.json"}}, {"family": "Lecce", "given": "Serena", "initials": "S", "orcid": "0000-0002-2745-3574", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1fd6450ec02142fb9640a78dcd7c9f83.json"}}, {"family": "Feng", "given": "Xin", "initials": "X", "orcid": "0000-0003-4046-5374", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0a3090940da46f081c5f017dffdea0d.json"}}, {"family": "Chan", "given": "Meingold H M", "initials": "MHM", "orcid": "0000-0001-9108-2504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5d5d31a0104485db02d180a25586206.json"}}, {"family": "Hughes", "given": "Claire", "initials": "C", "orcid": "0000-0003-2545-3025", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7032b296d5145428c9ac304f5a80378.json"}}], "type": "journal article", "published": "2022-08-22", "journal": {"title": "Int J Methods Psychiatr Res", "issn": "1557-0657", "pages": "e1933", "issn-l": null}, "abstract": "The Strengths and Difficulties Questionnaire (SDQ) has been shown to be invariant across informants, developmental stage and settings, but tests of cross-cultural equivalence are limited to adolescents' self-reports. The COVID-19 pandemic makes this gap particularly pertinent, given the need to understand whether distinct government approaches (e.g., school closures) are uniquely associated with variability in children's psychosocial outcomes and the reliance on parents' ratings for young children.\n\nWithin a Confirmatory Factor Analysis framework, we tested the cross-cultural measurement invariance of the SDQ across six countries: Australia, China, Italy, Sweden, the United Kingdom and USA, using a sample of 1761 parents of 3- to 8-year-olds (M = 5.76, SD = 1.09).\n\nA five-factors model showed good fit to the data and partial cross-cultural scalar invariance. In this sample, Swedish parents reported the fewest peer problems (Cohen's d = 0.950) and the highest prosocial scores (Cohen's d = 0.547), whilst British parents reported the greatest child emotional (Cohen's d = 0.412) and hyperactivity problems (Cohen's d = 0.535).\n\nThe present results indicate that the parent-version of the SDQ is appropriate for use and comparison across different contexts during the pandemic.", "doi": "10.1002/mpr.1933", "pmid": "35994374", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:59:43.015Z", "modified": "2022-09-12T18:59:43.208Z"}, {"entity": "publication", "iuid": "239a6b95cd38479fb8bf23f47400d393", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/239a6b95cd38479fb8bf23f47400d393.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/239a6b95cd38479fb8bf23f47400d393"}}, "title": "COVID-19 Modeling Outcome versus Reality in Sweden.", "authors": [{"family": "Carlsson", "given": "Marcus", "initials": "M", "orcid": "0000-0002-3761-9072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9492f80f98584a4c949a0114fb44ef71.json"}}, {"family": "S\u00f6derberg-Naucl\u00e9r", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-8955-3610", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f10026ba9a64bfea2fc49de969cdde9.json"}}], "type": "journal article", "published": "2022-08-22", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "8", "issn-l": "1999-4915"}, "abstract": "It has been very difficult to predict the development of the COVID-19 pandemic based on mathematical models for the spread of infectious diseases, and due to major non-pharmacological interventions (NPIs), it is still unclear to what extent the models would have fit reality in a \"do nothing\" scenario. To shed light on this question, the case of Sweden during the time frame from autumn 2020 to spring 2021 is particularly interesting, since the NPIs were relatively minor and only marginally updated. We found that state of the art models are significantly overestimating the spread, unless we assume that social interactions significantly decrease continuously throughout the time frame, in a way that does not correlate well with Google-mobility data nor updates to the NPIs or public holidays. This leads to the question of whether modern SEIR-type mathematical models are unsuitable for modeling the spread of SARS-CoV-2 in the human population, or whether some particular feature of SARS-CoV-2 dampened the spread. We show that, by assuming a certain level of pre-immunity to SARS-CoV-2, we obtain an almost perfect data-fit, and discuss what factors could cause pre-immunity in the mathematical models. In this scenario, a form of herd-immunity under the given restrictions was reached twice (first against the Wuhan-strain and then against the alpha-strain), and the ultimate decline in cases was due to depletion of susceptibles rather than the vaccination campaign.", "doi": "10.3390/v14081840", "pmid": "36016462", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9415753"}, {"db": "pii", "key": "v14081840"}], "notes": [], "created": "2022-09-12T19:14:03.232Z", "modified": "2023-07-13T11:29:53.833Z"}, {"entity": "publication", "iuid": "b6de4fc9b0434827b7ca222118639d0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b6de4fc9b0434827b7ca222118639d0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b6de4fc9b0434827b7ca222118639d0e"}}, "title": "Response to Frequency of new seizures after SARS-CoV-2 infections may depend on the length of follow-up.", "authors": [{"family": "Westman", "given": "Gabriel", "initials": "G"}, {"family": "Zelano", "given": "Johan", "initials": "J"}], "type": "letter", "published": "2022-08-20", "journal": {"title": "Seizure", "issn": "1532-2688", "issn-l": null}, "abstract": null, "doi": "10.1016/j.seizure.2022.08.006", "pmid": "36030113", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1059-1311(22)00185-6"}, {"db": "pmc", "key": "PMC9391083"}], "notes": [], "created": "2022-10-07T12:40:23.381Z", "modified": "2022-10-07T12:40:23.397Z"}, {"entity": "publication", "iuid": "1091fb0317e6482fa445eb910829a150", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1091fb0317e6482fa445eb910829a150.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1091fb0317e6482fa445eb910829a150"}}, "title": "Comparison of SARS-CoV-2 spike RNA sequences in feces and nasopharynx indicates intestinal replication.", "authors": [{"family": "Beck-Friis", "given": "Thomas", "initials": "T"}, {"family": "K\u00e4rmander", "given": "Ambj\u00f6rn", "initials": "A"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Wang", "given": "Hao", "initials": "H"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Norder", "given": "Hel\u00e9ne", "initials": "H"}], "type": "journal article", "published": "2022-08-20", "journal": {"title": "Gut Pathog", "issn": "1757-4749", "volume": "14", "issue": "1", "pages": "35", "issn-l": null}, "abstract": "Little is known of possible selection and replication of SARS-CoV-2 in the intestines and if viral load in feces is associated with severity of disease. Therefore, sequence variations of the spike region in strains collected from feces and nasopharynx (NPH) from the same patients were compared. It was also investigated whether viral load in feces related to severity of COVID-19 in hospitalized patients.\n\nSARS-CoV-2 RNA was found in 88 (79%) fecal samples from 112 patients. The complete spike region could be sequenced in 15 fecal and 14 NPH samples. Fourteen Alpha-variants and one Beta-variant of SARS-CoV-2 were identified. The majority of the viral genetic variants (viral populations) in two fecal samples, but none in NPH, had a reversion of the H69/V70 amino acid deletion normally seen in the Alpha variants. Nine fecal samples contained up to nine minority variants, each which may constitute a separate viral population. Five NPH samples had one genetic variant each, and one NPH sample contained nine minority populations of SARS-CoV-2 spike genes.\n\nThe higher genomic diversity of SARS-CoV-2 in feces compared to NPH, and the reversion of the H69/V70 deletion in Alpha variants from feces indicate a selection of viral strains and replication of SARS-CoV-2 in the gastrointestinal tract.", "doi": "10.1186/s13099-022-00509-w", "pmid": "35987708", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13099-022-00509-w"}, {"db": "pmc", "key": "PMC9392503"}], "notes": [], "created": "2022-09-12T18:48:29.511Z", "modified": "2022-09-12T18:48:29.537Z"}, {"entity": "publication", "iuid": "1fa3baf6ba384548a6d4e9676212cd2b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1fa3baf6ba384548a6d4e9676212cd2b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1fa3baf6ba384548a6d4e9676212cd2b"}}, "title": "COVID-19 and Politically Motivated Reasoning.", "authors": [{"family": "Maguire", "given": "Allegra", "initials": "A"}, {"family": "Persson", "given": "Emil", "initials": "E", "orcid": "0000-0003-2994-0541", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5722c7a43dbc4303859f72218a6739da.json"}}, {"family": "V\u00e4stfj\u00e4ll", "given": "Daniel", "initials": "D"}, {"family": "Tingh\u00f6g", "given": "Gustav", "initials": "G", "orcid": "0000-0002-8159-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c4dcebfe7b0425182298cf35259223c.json"}}], "type": "journal article", "published": "2022-08-20", "journal": {"title": "Med Decis Making", "issn": "1552-681X", "issn-l": null, "volume": null, "issue": null, "pages": "272989X221118078"}, "abstract": "During the COVID-19 pandemic, the world witnessed a partisan segregation of beliefs toward the global health crisis and its management. Politically motivated reasoning, the tendency to interpret information in accordance with individual motives to protect valued beliefs rather than objectively considering the facts, could represent a key process involved in the polarization of attitudes. The objective of this study was to explore politically motivated reasoning when participants assess information regarding COVID-19.\r\n\r\nWe carried out a preregistered online experiment using a diverse sample (N = 1500) from the United States. Both Republicans and Democrats assessed the same COVID-19-related information about the health effects of lockdowns, social distancing, vaccination, hydroxychloroquine, and wearing face masks.\r\n\r\nAt odds with our prestated hypothesis, we found no evidence in line with politically motivated reasoning when interpreting numerical information about COVID-19. Moreover, we found no evidence supporting the idea that numeric ability or cognitive sophistication bolster politically motivated reasoning in the case of COVID-19. Instead, our findings suggest that participants base their assessment on prior beliefs of the matter.\r\n\r\nOur findings suggest that politically polarized attitudes toward COVID-19 are more likely to be driven by lack of reasoning than politically motivated reasoning-a finding that opens potential avenues for combating political polarization about important health care topics.\r\n\r\nParticipants assessed numerical information regarding the effect of different COVID-19 policies.We found no evidence in line with politically motivated reasoning when interpreting numerical information about COVID-19.Participants tend to base their assessment of COVID-19-related facts on prior beliefs of the matter.Politically polarized attitudes toward COVID-19 are more a result of lack of thinking than partisanship.", "doi": "10.1177/0272989X221118078", "pmid": "35993415", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:53:25.098Z", "modified": "2022-11-09T08:37:33.249Z"}, {"entity": "publication", "iuid": "673f5eb1917b413d908fd5821b9cf280", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/673f5eb1917b413d908fd5821b9cf280.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/673f5eb1917b413d908fd5821b9cf280"}}, "title": "Pulmonary Embolism in Post-CoviD-19 Patients, a Literature Review: Red Flag for Increased Awareness?", "authors": [{"family": "Mouzarou", "given": "Angeliki", "initials": "A", "orcid": "0000-0002-6687-5075", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07a30f36479e44bc937fa4bd97026313.json"}}, {"family": "Ioannou", "given": "Maria", "initials": "M"}, {"family": "Leonidou", "given": "Elena", "initials": "E"}, {"family": "Chaziri", "given": "Ioanna", "initials": "I"}], "type": "journal article", "published": "2022-08-19", "journal": {"title": "SN Compr Clin Med", "issn": "2523-8973", "volume": "4", "issue": "1", "pages": "190", "issn-l": null}, "abstract": "Although COVID-19 was primarily considered a respiratory illness, rapidly accumulating data suggest that COVID-19 is associated with a high incidence of venous thromboembolic complications. The primary objective of this review article was to reveal whether we need to increase awareness of pulmonary embolism in the period following the COVID-19 infection given that the epidemiologic facts are still poor. A literature search and a critical review of the collected studies were conducted. An electronic search of PubMed, Science Direct Scopus, Google Scholar, and Excerpta Medica Database (EMBASE) from June 2020 until June 2022. The long-term health consequences of COVID-19 remain largely unclear. This review highlights the importance of awareness of the potentially increased incidence of venous thromboembolism in post-COVID-19 patients, even those with mild or asymptomatic disease. Further research is required to establish appropriate clinical management guidelines for the prevention of thromboembolic complications in the post-COVID-19 period.", "doi": "10.1007/s42399-022-01273-3", "pmid": "35999860", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "1273"}, {"db": "pmc", "key": "PMC9389494"}], "notes": [], "created": "2022-08-26T04:44:27.340Z", "modified": "2022-08-26T04:44:27.396Z"}, {"entity": "publication", "iuid": "3ca706b10da844938e6670e29373f1c8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ca706b10da844938e6670e29373f1c8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ca706b10da844938e6670e29373f1c8"}}, "title": "Global Prevalence and Potential Influencing Factors of COVID-19 Vaccination Hesitancy: A Meta-Analysis.", "authors": [{"family": "Fajar", "given": "Jonny Karunia", "initials": "JK", "orcid": "0000-0002-0309-5813", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5fb04d101ce4d20a4cb8692bbd67659.json"}}, {"family": "Sallam", "given": "Malik", "initials": "M", "orcid": "0000-0002-0165-9670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb490d3ed32f4b76b8a39bd0320bd748.json"}}, {"family": "Soegiarto", "given": "Gatot", "initials": "G", "orcid": "0000-0002-9197-3873", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ead7821cabe648c6a2c0ec9596015f55.json"}}, {"family": "Sugiri", "given": "Yani Jane", "initials": "YJ"}, {"family": "Anshory", "given": "Muhammad", "initials": "M"}, {"family": "Wulandari", "given": "Laksmi", "initials": "L"}, {"family": "Kosasih", "given": "Stephanie Astrid Puspitasari", "initials": "SAP"}, {"family": "Ilmawan", "given": "Muhammad", "initials": "M"}, {"family": "Kusnaeni", "given": "Kusnaeni", "initials": "K"}, {"family": "Fikri", "given": "Muhammad", "initials": "M"}, {"family": "Putri", "given": "Frilianty", "initials": "F"}, {"family": "Hamdi", "given": "Baitul", "initials": "B"}, {"family": "Pranatasari", "given": "Izza Dinalhaque", "initials": "ID"}, {"family": "Aina", "given": "Lily", "initials": "L", "orcid": "0000-0002-3083-9507", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9fe14a514c9c4768a81272f1dd18e10d.json"}}, {"family": "Maghfiroh", "given": "Lailatul", "initials": "L", "orcid": "0000-0002-6923-3887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9869ffbdd0924f06aef5a9f343c342a6.json"}}, {"family": "Ikhriandanti", "given": "Fernanda Septi", "initials": "FS"}, {"family": "Endiaverni", "given": "Wa Ode", "initials": "WO"}, {"family": "Nugraha", "given": "Krisna Wahyu", "initials": "KW", "orcid": "0000-0001-9188-0346", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8909f02dd3c24e258843c32ea5e903d4.json"}}, {"family": "Wiranudirja", "given": "Ory", "initials": "O"}, {"family": "Edinov", "given": "Sally", "initials": "S"}, {"family": "Hamdani", "given": "Ujang", "initials": "U", "orcid": "0000-0001-8867-0030", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ccfb26ce87148e899456efcec7caea9.json"}}, {"family": "Rosyidah", "given": "Lathifatul", "initials": "L"}, {"family": "Lubaba", "given": "Hanny", "initials": "H"}, {"family": "Ariwibowo", "given": "Rinto", "initials": "R"}, {"family": "Andistyani", "given": "Riska", "initials": "R"}, {"family": "Fitriani", "given": "Ria", "initials": "R"}, {"family": "Hasanah", "given": "Miftahul", "initials": "M"}, {"family": "Nafis", "given": "Fardha Ad Durrun", "initials": "FAD"}, {"family": "Tamara", "given": "Fredo", "initials": "F"}, {"family": "Latamu", "given": "Fitri Olga", "initials": "FO"}, {"family": "Kusuma", "given": "Hendrix Indra", "initials": "HI", "orcid": "0000-0003-3555-0136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d3daa17c23742d0ba36d8dad2d7be79.json"}}, {"family": "Rabaan", "given": "Ali A", "initials": "AA", "orcid": "0000-0002-6774-9847", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6f7d6e2db1e34c19ab20d96af6cf384d.json"}}, {"family": "Alhumaid", "given": "Saad", "initials": "S", "orcid": "0000-0003-4552-4513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5b42c928b1a4d75840ad62b355d06f7.json"}}, {"family": "Mutair", "given": "Abbas Al", "initials": "AA"}, {"family": "Garout", "given": "Mohammed", "initials": "M"}, {"family": "Halwani", "given": "Muhammad A", "initials": "MA"}, {"family": "Alfaresi", "given": "Mubarak", "initials": "M", "orcid": "0000-0003-2523-835X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9115c5a248448748bc57159a479f0e8.json"}}, {"family": "Al Azmi", "given": "Reyouf", "initials": "R"}, {"family": "Alasiri", "given": "Nada A", "initials": "NA", "orcid": "0000-0003-2549-9904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1068b2b4acd46988f349835bda1eccf.json"}}, {"family": "Alshukairi", "given": "Abeer N", "initials": "AN"}, {"family": "Dhama", "given": "Kuldeep", "initials": "K", "orcid": "0000-0001-7469-4752", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef8824b2d5dc494ca3c21dc5e783e677.json"}}, {"family": "Harapan", "given": "Harapan", "initials": "H", "orcid": "0000-0001-7630-8413", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06f2d40c26be48cd8ba815701674b0f1.json"}}], "type": "journal article", "published": "2022-08-19", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "Countries worldwide have deployed mass COVID-19 vaccination drives, but there are people who are hesitant to receive the vaccine. Studies assessing the factors associated with COVID-19 vaccination hesitancy are inconclusive. This study aimed to assess the global prevalence of COVID-19 vaccination hesitancy and determine the potential factors associated with such hesitancy. We performed an organized search for relevant articles in PubMed, Scopus, and Web of Science. Extraction of the required information was performed for each study. A single-arm meta-analysis was performed to determine the global prevalence of COVID-19 vaccination hesitancy; the potential factors related to vaccine hesitancy were analyzed using a Z-test. A total of 56 articles were included in our analysis. We found that the global prevalence of COVID-19 vaccination hesitancy was 25%. Being a woman, being a 50-year-old or younger, being single, being unemployed, living in a household with five or more individuals, having an educational attainment lower than an undergraduate degree, having a non-healthcare-related job and considering COVID-19 vaccines to be unsafe were associated with a higher risk of vaccination hesitancy. In contrast, living with children at home, maintaining physical distancing norms, having ever tested for COVID-19, and having a history of influenza vaccination in the past few years were associated with a lower risk of hesitancy to COVID-19 vaccination. Our study provides valuable information on COVID-19 vaccination hesitancy, and we recommend special interventions in the sub-populations with increased risk to reduce COVID-19 vaccine hesitancy.", "doi": "10.3390/vaccines10081356", "pmid": "36016242", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "vaccines10081356"}, {"db": "pmc", "key": "PMC9412456"}], "notes": [], "created": "2022-09-12T19:13:23.853Z", "modified": "2022-09-12T19:13:46.052Z"}, {"entity": "publication", "iuid": "38520aadc94b49758014b1674c74bf4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38520aadc94b49758014b1674c74bf4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38520aadc94b49758014b1674c74bf4d"}}, "title": "Complement C3 inhibition in severe COVID-19 using compstatin AMY-101.", "authors": [{"family": "Skendros", "given": "Panagiotis", "initials": "P", "orcid": "0000-0003-0456-7015", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f3964bd31a644fb9edb3ddb8012d6ae.json"}}, {"family": "Germanidis", "given": "Georgios", "initials": "G", "orcid": "0000-0001-7985-3118", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b064677471a4dfca38ef7e09409822e.json"}}, {"family": "Mastellos", "given": "Dimitrios C", "initials": "DC", "orcid": "0000-0002-6634-3271", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a842782e093409fa426e83d3ef99663.json"}}, {"family": "Antoniadou", "given": "Christina", "initials": "C", "orcid": "0000-0001-7391-6851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c51d5f05105f49ea9303e95bd81cc91e.json"}}, {"family": "Gavriilidis", "given": "Efstratios", "initials": "E", "orcid": "0000-0002-1591-9760", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a54d5da4ddd49f9b478dcb93bc9205f.json"}}, {"family": "Kalopitas", "given": "Georgios", "initials": "G", "orcid": "0000-0002-4962-790X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ec02ed547494cd4a5648a76204675d2.json"}}, {"family": "Samakidou", "given": "Anna", "initials": "A"}, {"family": "Liontos", "given": "Angelos", "initials": "A", "orcid": "0000-0002-0361-0846", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70560431d93d43e2a48579c019d7fcad.json"}}, {"family": "Chrysanthopoulou", "given": "Akrivi", "initials": "A"}, {"family": "Ntinopoulou", "given": "Maria", "initials": "M"}, {"family": "Kogias", "given": "Dionysios", "initials": "D", "orcid": "0000-0002-2505-7076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7914e0d4d3d64f18855f716e8f7f2910.json"}}, {"family": "Karanika", "given": "Ioanna", "initials": "I"}, {"family": "Smyrlis", "given": "Andreas", "initials": "A", "orcid": "0000-0002-3964-5944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9948578678704ba99655ee7d8eecda93.json"}}, {"family": "Cepaityte", "given": "Dainora", "initials": "D", "orcid": "0000-0003-2652-4120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f9344cdf81d4d1293b919741dd63a6e.json"}}, {"family": "Fotiadou", "given": "Iliana", "initials": "I", "orcid": "0000-0002-7618-4243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa2fc15ebd174048a197345093f8a2e5.json"}}, {"family": "Zioga", "given": "Nikoleta", "initials": "N", "orcid": "0000-0002-8614-6742", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed19a1127a244e4891d8460adf6f93c4.json"}}, {"family": "Mitroulis", "given": "Ioannis", "initials": "I"}, {"family": "Gatselis", "given": "Nikolaos K", "initials": "NK", "orcid": "0000-0002-3715-8640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48a938526b5c4b14bd32e1f0dd90b6f8.json"}}, {"family": "Papagoras", "given": "Charalampos", "initials": "C", "orcid": "0000-0001-6207-496X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1ed3220f27c4dd4bcd76135200ebb4c.json"}}, {"family": "Metallidis", "given": "Simeon", "initials": "S"}, {"family": "Milionis", "given": "Haralampos", "initials": "H", "orcid": "0000-0003-3958-2266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d08064024f26409a98b57a024329787a.json"}}, {"family": "Dalekos", "given": "George N", "initials": "GN", "orcid": "0000-0001-7075-8464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4c60cecbf7d4316b5a2e64267ec7925.json"}}, {"family": "Willems", "given": "Loek", "initials": "L"}, {"family": "Persson", "given": "Barbro", "initials": "B"}, {"family": "Manivel", "given": "Vivek Anand", "initials": "VA", "orcid": "0000-0002-6746-7372", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c45a913d5fdc4446987103f9519cf28f.json"}}, {"family": "Nilsson", "given": "Bo", "initials": "B"}, {"family": "Connolly", "given": "E Sander", "initials": "ES"}, {"family": "Iacobelli", "given": "Simona", "initials": "S"}, {"family": "Papadopoulos", "given": "Vasileios", "initials": "V", "orcid": "0000-0002-4188-9518", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6576628a0472453499d211ea786bdc89.json"}}, {"family": "Calado", "given": "Rodrigo T", "initials": "RT", "orcid": "0000-0002-7966-6029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9cc3032ec8444cf69e4bd24bbc1a1c79.json"}}, {"family": "Huber-Lang", "given": "Markus", "initials": "M", "orcid": "0000-0003-2359-6516", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d93a6fbd9f6446f58a91c65078b4dec0.json"}}, {"family": "Risitano", "given": "Antonio M", "initials": "AM"}, {"family": "Yancopoulou", "given": "Despina", "initials": "D"}, {"family": "Ritis", "given": "Konstantinos", "initials": "K"}, {"family": "Lambris", "given": "John D", "initials": "JD", "orcid": "0000-0002-9370-5776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3feb5c64951b4305b97bcffa49e6154a.json"}}], "type": "journal article", "published": "2022-08-19", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "8", "issue": "33", "pages": "eabo2341", "issn-l": "2375-2548"}, "abstract": "Complement C3 activation contributes to COVID-19 pathology, and C3 targeting has emerged as a promising therapeutic strategy. We provide interim data from ITHACA, the first randomized trial evaluating a C3 inhibitor, AMY-101, in severe COVID-19 (PaO2/FiO2 \u2264 300 mmHg). Patients received AMY-101 (n = 16) or placebo (n = 15) in addition to standard of care. AMY-101 was safe and well tolerated. Compared to placebo (8 of 15, 53.3%), a higher, albeit nonsignificant, proportion of AMY-101-treated patients (13 of 16, 81.3%) were free of supplemental oxygen at day 14. Three nonresponders and two placebo-treated patients succumbed to disease-related complications. AMY-101 significantly reduced CRP and ferritin and restrained thrombin and NET generation. Complete and sustained C3 inhibition was observed in all responders. Residual C3 activity in the three nonresponders suggested the presence of a convertase-independent C3 activation pathway overriding the drug's inhibitory activity. These findings support the design of larger trials exploring the potential of C3-based inhibition in COVID-19 or other complement-mediated diseases.", "doi": "10.1126/sciadv.abo2341", "pmid": "35977025", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9385148"}], "notes": [], "created": "2022-09-12T18:39:40.359Z", "modified": "2022-09-12T18:39:41.017Z"}, {"entity": "publication", "iuid": "1a68a79d4505455ab7cb857cd82eafca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1a68a79d4505455ab7cb857cd82eafca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1a68a79d4505455ab7cb857cd82eafca"}}, "title": "Acute Kidney Injury in COVID-19 Patients: Pathogenesis, Clinical Characteristics, Therapy, and Mortality.", "authors": [{"family": "Ch\u00e1vez-Valencia", "given": "Venice", "initials": "V"}, {"family": "Orizaga-de-la-Cruz", "given": "Citlalli", "initials": "C"}, {"family": "Lagunas-Rangel", "given": "Francisco Alejandro", "initials": "FA", "orcid": "0000-0001-7730-6452", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/737bd8eaf59a4ae28b71f4270c1f56c3.json"}}], "type": "journal article", "published": "2022-08-19", "journal": {"title": "Diseases", "issn": "2079-9721", "volume": "10", "issue": "3", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) is a disease caused by infection with the SARS-CoV-2 virus and has represented one of the greatest challenges humanity has faced in recent years. The virus can infect a large number of organs, including the lungs and upper respiratory tract, brain, liver, kidneys, and intestines, among many others. Although the greatest damage occurs in the lungs, the kidneys are not exempt, and acute kidney injury (AKI) can occur in patients with COVID-19. Indeed, AKI is one of the most frequent and serious organic complications of COVID-19. The incidence of COVID-19 AKI varies widely, and the exact mechanisms of how the virus damages the kidney are still unknown. For this reason, the purpose of this review was to assess current findings on the pathogenesis, clinical features, therapy, and mortality of COVID-19 AKI.", "doi": "10.3390/diseases10030053", "pmid": "35997358", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "diseases10030053"}], "notes": [], "created": "2022-08-26T04:45:32.548Z", "modified": "2022-08-26T04:45:32.621Z"}, {"entity": "publication", "iuid": "e71abb03bfb741cbb5c70008a6c0cd26", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e71abb03bfb741cbb5c70008a6c0cd26.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e71abb03bfb741cbb5c70008a6c0cd26"}}, "title": "A universal SARS-CoV DNA vaccine inducing highly cross-reactive neutralizing antibodies and T cells.", "authors": [{"family": "Appelberg", "given": "Sofia", "initials": "S", "orcid": "0000-0002-7381-3606", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a3e2ab8513742af91714b79b472734a.json"}}, {"family": "Ahl\u00e9n", "given": "Gustaf", "initials": "G", "orcid": "0000-0002-2681-6433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eda17940966a4e059f1598116f8572bf.json"}}, {"family": "Yan", "given": "Jingyi", "initials": "J", "orcid": "0000-0002-2266-7338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/071873148bdc4d588d050516bc7d44b0.json"}}, {"family": "Nikouyan", "given": "Negin", "initials": "N", "orcid": "0000-0003-3588-2448", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fefca010183442c093b01849a08149c6.json"}}, {"family": "Weber", "given": "Sofie", "initials": "S"}, {"family": "Larsson", "given": "Olivia", "initials": "O"}, {"family": "H\u00f6glund", "given": "Urban", "initials": "U"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Weber", "given": "Friedemann", "initials": "F", "orcid": "0000-0001-9737-337X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cfac6ca689c5467396ede57ba57092da.json"}}, {"family": "Perlhamre", "given": "Emma", "initials": "E"}, {"family": "Apro", "given": "Johanna", "initials": "J"}, {"family": "Gidlund", "given": "Eva-Karin", "initials": "E"}, {"family": "Tuvesson", "given": "Ola", "initials": "O", "orcid": "0000-0003-2232-026X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/99b2a259824c4a7abac326481f01bc28.json"}}, {"family": "Salati", "given": "Simona", "initials": "S", "orcid": "0000-0002-8072-1128", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd374f0c8bc34c028ba321a68aa4b85e.json"}}, {"family": "Cadossi", "given": "Matteo", "initials": "M"}, {"family": "Tegel", "given": "Hanna", "initials": "H", "orcid": "0000-0002-7067-9173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d3fde7ee5de4dab899746becfae364d.json"}}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Frelin", "given": "Lars", "initials": "L", "orcid": "0000-0001-7452-1667", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd26ddedec244820a9a1e19f76cc5cf8.json"}}, {"family": "Mirazimi", "given": "Ali", "initials": "A", "orcid": "0000-0003-2371-6055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0651be47429c4e5880a13b839d04fe1d.json"}}, {"family": "S\u00e4llberg", "given": "Matti", "initials": "M", "orcid": "0000-0002-8858-5132", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ef589af054b4f94a635ce4021d19ed6.json"}}], "type": "journal article", "published": "2022-08-19", "journal": {"title": "EMBO Mol Med", "issn": "1757-4684", "issn-l": "1757-4676", "volume": null, "issue": null, "pages": "e15821"}, "abstract": "New variants in the SARS-CoV-2 pandemic are more contagious (Alpha/Delta), evade neutralizing antibodies (Beta), or both (Omicron). This poses a challenge in vaccine development according to WHO. We designed a more universal SARS-CoV-2 DNA vaccine containing receptor-binding domain loops from the huCoV-19/WH01, the Alpha, and the Beta variants, combined with the membrane and nucleoproteins. The vaccine induced spike antibodies crossreactive between huCoV-19/WH01, Beta, and Delta spike proteins that neutralized huCoV-19/WH01, Beta, Delta, and Omicron virus in vitro. The vaccine primed nucleoprotein-specific T cells, unlike spike-specific T cells, recognized Bat-CoV sequences. The vaccine protected mice carrying the human ACE2 receptor against lethal infection with the SARS-CoV-2 Beta variant. Interestingly, priming of cross-reactive nucleoprotein-specific T cells alone was 60% protective, verifying observations from humans that T cells protect against lethal disease. This SARS-CoV vaccine induces a uniquely broad and functional immunity that adds to currently used vaccines.", "doi": "10.15252/emmm.202215821", "pmid": "35986481", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:46:48.046Z", "modified": "2022-09-12T18:47:48.444Z"}, {"entity": "publication", "iuid": "5cd512c8ebc74a6aab9caeb6f2afed41", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5cd512c8ebc74a6aab9caeb6f2afed41.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5cd512c8ebc74a6aab9caeb6f2afed41"}}, "title": "Trends in upper respiratory tract infections and antibiotic prescriptions during the COVID-19 pandemic - a national observational study.", "authors": [{"family": "Gisselsson-Solen", "given": "Marie", "initials": "M", "orcid": "0000-0003-2802-2343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef722726120a4d26ad687988eb841f80.json"}}, {"family": "Hermansson", "given": "Ann", "initials": "A"}], "type": "editorial", "published": "2022-08-18", "journal": {"title": "Acta Otolaryngol", "issn": "1651-2251", "pages": "1-4", "issn-l": "0001-6489"}, "abstract": null, "doi": "10.1080/00016489.2022.2109727", "pmid": "35980331", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:43:07.012Z", "modified": "2022-09-12T18:43:07.066Z"}, {"entity": "publication", "iuid": "76b43f698f12496a8052cbbfcdc0ddfe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76b43f698f12496a8052cbbfcdc0ddfe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76b43f698f12496a8052cbbfcdc0ddfe"}}, "title": "Selective Serotonin Reuptake Inhibitors may Influence COVID-19 Prognosis through Antioxidant and Cytoprotective Pathways Mediated by Sigma 1 Receptor Agonism.", "authors": [{"family": "Papadopoulos", "given": "Konstantinos I", "initials": "KI", "orcid": "0000-0003-0041-7853", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/57c63fdf7036465686e79794a5107544.json"}}, {"family": "Papadopoulou", "given": "Alexandra", "initials": "A", "orcid": "0000-0002-7488-8271", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9000ff7673bc4d35bde729ce8829ab5d.json"}}, {"family": "Aw", "given": "Tar-Choon", "initials": "TC", "orcid": "0000-0002-7814-8836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f95d6a8535d41fbb7b5cf40fb091205.json"}}], "type": "journal article", "published": "2022-08-18", "journal": {"title": "Pharmacopsychiatry", "issn": "1439-0795", "issn-l": null}, "abstract": null, "doi": "10.1055/a-1909-2198", "pmid": "35981550", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:45:06.412Z", "modified": "2022-09-12T18:45:22.624Z"}, {"entity": "publication", "iuid": "16a3ca6332634a2791bbb8a73799d0af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16a3ca6332634a2791bbb8a73799d0af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16a3ca6332634a2791bbb8a73799d0af"}}, "title": "An interrupted time series analysis of gambling behavior based on gambling operator revenue-based taxation during the COVID-19 pandemic in Sweden.", "authors": [{"family": "Andersson", "given": "M J", "initials": "MJ"}, {"family": "Balem", "given": "M", "initials": "M"}, {"family": "H\u00e5kansson", "given": "A", "initials": "A"}], "type": "journal article", "published": "2022-08-18", "journal": {"title": "Public Health", "issn": "1476-5616", "volume": "211", "pages": "14-20", "issn-l": null}, "abstract": "The impact of COVID-19 on gambling behavior and the gambling industry itself has been widely speculated. Prior studies have shown how boredom, social isolation, poor mental health, and financial hardships, all of which have been associated with COVID-19, can aggravate problem gambling behaviors in patients with gambling disorders while also luring newcomers. Few studies have used methods other than self-report to assess longitudinal behavioral changes in gambling behavior before versus during the pandemic.\n\nThe present study addresses this gap by using an interrupted time series approach on data obtained from the Swedish Gambling Authority measuring taxation on gambling vendors' revenue between January 2019 and November 2021.\n\nMarch, June, and October 2020 were chosen as interruption points as they correspond to the pandemic's commencement, the return of elite sports, and the second wave of cases in Sweden, respectively. We hypothesized that the pandemic would be associated with both temporary changes for select gambling types and long-term increases in online gambling.\n\nResults revealed the pandemic's onset was associated with transient effects at each point of interruption, as well as long-term upward trends in total gambling and commercial online gambling, excluding horse betting and the state-owned operator for online casinos and betting.\n\nThe present study's findings, although consistent with the theory that gambling activity could increase during the pandemic, contradict previous studies that found no changes or a decrease from pre-COVID-19 levels. Findings indicate that the pandemic and Sweden's reaction to it were associated with increased use of some gambling products.", "doi": "10.1016/j.puhe.2022.07.003", "pmid": "35988505", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0033-3506(22)00198-6"}], "notes": [], "created": "2022-09-12T18:49:20.251Z", "modified": "2022-09-12T18:49:20.257Z"}, {"entity": "publication", "iuid": "6b199a2fa90e431687b033fc4dc3f90f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b199a2fa90e431687b033fc4dc3f90f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b199a2fa90e431687b033fc4dc3f90f"}}, "title": "Patient lead users experience of the COVID-19 pandemic: a qualitative interview study.", "authors": [{"family": "Jansson", "given": "Hanna", "initials": "H", "orcid": "0000-0002-1615-0463", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88337ae732344b7fb3ebc5a04ef9894b.json"}}, {"family": "Stenfors", "given": "Terese", "initials": "T", "orcid": "0000-0002-0854-8631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/785692870b584906b79702cbfdac8866.json"}}, {"family": "Riggare", "given": "Sara", "initials": "S", "orcid": "0000-0002-2256-7310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ffa9b36c39043578cfa21a881699ea7.json"}}, {"family": "Hasson", "given": "Henna", "initials": "H", "orcid": "0000-0002-3827-6841", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1c2ba4af37b4c678656ea948b76fa93.json"}}, {"family": "Reinius", "given": "Maria", "initials": "M", "orcid": "0000-0003-0864-8701", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8dc0b4c1305b49349adfb8f4da310856.json"}}], "type": "journal article", "published": "2022-08-17", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "8", "pages": "e059003", "issn-l": "2044-6055"}, "abstract": "Patient lead users can be defined as patients or relatives who use their knowledge and experience to improve their own or a relative's care situation and/or the healthcare system, and who are active beyond what is usually expected. The objective of this study is to explore patient lead users' experiences and engagement during the early COVID-19 pandemic.\n\nQualitative in-depth interviews with a cross-sectional time horizon.\n\nThe early COVID-19 pandemic in Sweden, from 1 June through 14 September, 2020.\n\nA total of 10 patient lead users were recruited from the Swedish patient lead users (spetspatient) network. All participants were living with different long-term conditions and matched the definition of being patient lead users.\n\nWe found that during the early pandemic, patient lead users experienced that they no longer knew how to best manage their own health and care situations. On an individual level, they described an initial lack of knowledge, new routines, including a change in their health and an experience of people without a disease being in the same situation as them, for a while. On a systemic level, they described a fear of imminent unmet-care backlogs and decreased opportunities for sharing patient perspectives in care organisation, but also described increased networking.\n\nPatient lead users can be seen as an emerging community of practice, and as such could be a valuable resource as a complementary communication channel for an improved health system. The health systems were not able to fully acknowledge and engage with the resource of patient lead users during the pandemic.", "doi": "10.1136/bmjopen-2021-059003", "pmid": "35977768", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-059003"}, {"db": "pmc", "key": "PMC9388713"}], "notes": [], "created": "2022-09-12T18:40:01.486Z", "modified": "2022-09-12T18:40:01.671Z"}, {"entity": "publication", "iuid": "6d6ea640ecfb4b2e89afbd38ac585f69", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6d6ea640ecfb4b2e89afbd38ac585f69.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6d6ea640ecfb4b2e89afbd38ac585f69"}}, "title": "How much are we worth? Experiences of nursing assistants in Swedish nursing homes during the first wave of COVID-19.", "authors": [{"family": "Bergqvist", "given": "Monica", "initials": "M", "orcid": "0000-0002-3061-4885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/024ed86bac7d4d64a4073057c79f05e1.json"}}, {"family": "Bastholm-Rahmner", "given": "Pia", "initials": "P"}, {"family": "Gustafsson", "given": "Lars L", "initials": "LL"}, {"family": "Holmgren", "given": "Katarina", "initials": "K"}, {"family": "Veg", "given": "Anik\u00f3", "initials": "A"}, {"family": "Wachtler", "given": "Caroline", "initials": "C"}, {"family": "Schmidt-Mende", "given": "Katharina", "initials": "K"}], "type": "journal article", "published": "2022-08-17", "journal": {"title": "Int J Older People Nurs", "issn": "1748-3743", "pages": "e12498", "issn-l": null}, "abstract": "NHs have been severely exposed during the COVID-19 pandemic. Little is known about how staff who provide practical daily care of older residents experienced work during the pandemic. The aim of this study was to understand how nursing assistants (NAs) experienced their work at nursing homes (NHs) for older people during the first wave of the COVID-19 pandemic.\n\nWe conducted a qualitative study of focus group discussions with in total 20 participants from four NHs in Stockholm, Sweden. Discussions were held in November 2020. Transcripts were analyzed using inductive thematic analysis.\n\nWe identified three major themes: 1) We felt abandoned, scared and disrespected, 2) We made sure we made it through, and 3) We can do good work with appropriate resources. NAs felt disregarded as they were often left alone without adequate support from managers, registered nurses and the municipalities. NAs felt distressed and guilty and developed their own strategies to cope and manage their work.\n\nDuring the first wave of the COVID-19 pandemic NAs felt abandoned and burdened due to lack of leadership. Organizational improvements are required to protect the wellbeing of NAs and to ensure sustainability of patient safety. NAs are crucial in the care for vulnerable older people and their experiences should constitute a keystone for development of future policy and practice in NHs.", "doi": "10.1111/opn.12498", "pmid": "35978489", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:41:01.840Z", "modified": "2022-09-12T18:41:01.886Z"}, {"entity": "publication", "iuid": "cc3a334d201a409581528d405736ac48", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc3a334d201a409581528d405736ac48.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc3a334d201a409581528d405736ac48"}}, "title": "Efficacy of Kan Jang\u00ae in Patients with Mild COVID-19: Interim Analysis of a Randomized, Quadruple-Blind, Placebo-Controlled Trial.", "authors": [{"family": "Ratiani", "given": "Levan", "initials": "L"}, {"family": "Pachkoria", "given": "Elene", "initials": "E"}, {"family": "Mamageishvili", "given": "Nato", "initials": "N"}, {"family": "Shengelia", "given": "Ramaz", "initials": "R"}, {"family": "Hovhannisyan", "given": "Areg", "initials": "A"}, {"family": "Panossian", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8467-4525", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86a40ce1842b4c289c7f09c955ad4325.json"}}], "type": "journal article", "published": "2022-08-17", "journal": {"title": "Pharmaceuticals (Basel)", "issn": "1424-8247", "volume": "15", "issue": "8", "issn-l": null}, "abstract": "Kan Jang\u00ae, the fixed combination of Andrographis paniculata (Burm. F.) Wall. ex. Nees and Eleutherococcus senticosus (Rupr. & Maxim.) Maxim extracts, is a herbal medicinal product for relieving symptoms of upper respiratory tract infections. This study aimed to assess the efficacy of Kan Jang\u00ae/Nergecov\u00ae on duration and the relief of inflammatory symptoms in adults with mild COVID-19. 86 patients with laboratory-confirmed COVID-19 and mild symptoms for one to three days received supportive treatment (paracetamol) and six Kan Jang\u00ae (daily dose of andrographolides-90 mg) or placebo capsules a day for 14 consecutive days in this randomized, quadruple-blinded, placebo-controlled, two-parallel-group study. The primary efficacy outcomes were the decrease in the acute-phase duration and the severity of symptoms score (sore throat, runny nose, cough, headache, fatigue, loss of smell, taste, pain in muscles), an increase in cognitive functions, physical performance, quality of life, and decrease in IL-6, c-reactive protein, and D-dimer in blood. Kan Jang\u00ae/Nergecov\u00ae was effective in reducing the risk of progression to severe COVID-19, decreasing the disease progression rate by almost 2.5-fold compared to placebo. Absolute risk reduction by Kan Jang treatment is 14%, the relative risk reduction is 243.9%, and the number Needed to Treat is 7.14. Kan Jang\u00ae/Nergecov\u00ae reduces the duration of disease, virus clearance, and days of hospitalization and accelerates recovery of patients, relief of sore throat, muscle pain, runny nose, and normalization of body temperature. Kan Jang\u00ae/Nergecov\u00ae significantly relieves the severity of inflammatory symptoms such as sore throat, runny nose, and muscle pain, decreases pro-inflammatory cytokine IL-6 level in the blood, and increases patients' physical performance (workout) compared to placebo. In this study, for the first time we demonstrate that Kan Jang\u00ae/Nergecov\u00ae is effective in treating mild COVID-19.", "doi": "10.3390/ph15081013", "pmid": "36015163", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ph15081013"}, {"db": "pmc", "key": "PMC9415141"}], "notes": [], "created": "2022-09-12T19:09:35.337Z", "modified": "2022-09-12T19:10:23.139Z"}, {"entity": "publication", "iuid": "f2efe20b1f2d4472831be246d161f6c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f2efe20b1f2d4472831be246d161f6c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f2efe20b1f2d4472831be246d161f6c9"}}, "title": "Impact of ultra-processed food intake on the risk of COVID-19: a prospective cohort study.", "authors": [{"family": "Zhou", "given": "Lihui", "initials": "L"}, {"family": "Li", "given": "Huiping", "initials": "H"}, {"family": "Zhang", "given": "Shunming", "initials": "S"}, {"family": "Yang", "given": "Hongxi", "initials": "H"}, {"family": "Ma", "given": "Yue", "initials": "Y"}, {"family": "Wang", "given": "Yaogang", "initials": "Y"}], "type": "journal article", "published": "2022-08-16", "journal": {"title": "Eur J Nutr", "issn": "1436-6215", "issn-l": null}, "abstract": "Nutrition plays a key role in supporting the human immune system and reducing the risk of infections. However, there is limited evidence exploring the relationship between diet and the risk of COVID-19. This study aimed to assess the associations between consumption of ultra-processed foods (UPF) and COVID-19 risk.\n\nIn total, 41,012 participants from the UK Biobank study with at least 2 of up to 5 times 24-h dietary assessments were included in this study. Dietary intakes were collected using an online 24-h dietary recall questionnaire and food items were categorized according to their degree of processing by the NOVA classification. COVID-19 infection was defined as individuals tested COVID-19 positive or dead of COVID-19. Association between average UPF consumption (% daily gram intake) and COVID-19 infection was assessed by multivariable logistic regression adjusted for potential confounders.\n\nCompared to participants in the lowest quartile of UPF proportion (% daily gram intake) in the diet, participants in the 2nd, 3rd, and highest quartiles were associated with a higher risk of COVID-19 with the odds ratio (OR) value of 1.03 (95% CI: 0.94-1.13), 1.24 (95% CI: 1.13-1.36), and 1.22 (95% CI: 1.12-1.34), respectively (P for trend < 0.001), after adjusting for potential confounders. The results were robust in a series of sensitivity analyses. No interaction effect was identified between the UPF proportions and age groups, education level, body mass index, and comorbidity status. BMI mediated 13.2% of this association.\n\nHigher consumption of UPF was associated with an increased risk of COVID-19 infection. Further studies are needed to better understand the underlying mechanisms in such association.", "doi": "10.1007/s00394-022-02982-0", "pmid": "35972529", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00394-022-02982-0"}], "notes": [], "created": "2022-08-19T05:25:41.640Z", "modified": "2022-08-19T05:25:41.676Z"}, {"entity": "publication", "iuid": "9564edc63b0b4c53aca2c2efaa8d8244", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9564edc63b0b4c53aca2c2efaa8d8244.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9564edc63b0b4c53aca2c2efaa8d8244"}}, "title": "Fundamental social motives measured across forty-two cultures in two waves.", "authors": [{"family": "Pick", "given": "Cari M", "initials": "CM", "orcid": "0000-0002-3703-156X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78a16cde2616434d8b45e193bb7a4d2b.json"}}, {"family": "Ko", "given": "Ahra", "initials": "A"}, {"family": "Kenrick", "given": "Douglas T", "initials": "DT"}, {"family": "Wiezel", "given": "Adi", "initials": "A"}, {"family": "Wormley", "given": "Alexandra S", "initials": "AS", "orcid": "0000-0001-9892-6087", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd7c1f83116043b9b0aafb8eba3ce0f2.json"}}, {"family": "Awad", "given": "Edmond", "initials": "E", "orcid": "0000-0001-7272-7186", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3399850d2c804849830ada06b5a2c264.json"}}, {"family": "Al-Shawaf", "given": "Laith", "initials": "L", "orcid": "0000-0002-8600-0591", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5da08e43eb45476cb8f58e402a30a220.json"}}, {"family": "Barry", "given": "Oumar", "initials": "O"}, {"family": "Bereby-Meyer", "given": "Yoella", "initials": "Y"}, {"family": "Boonyasiriwat", "given": "Watcharaporn", "initials": "W"}, {"family": "Brandst\u00e4tter", "given": "Eduard", "initials": "E"}, {"family": "Ceylan-Batur", "given": "Suzan", "initials": "S"}, {"family": "Choy", "given": "Bryan K C", "initials": "BKC"}, {"family": "Crispim", "given": "Ana Carla", "initials": "AC", "orcid": "0000-0003-3434-5667", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92a6c50510514095856558adcbcea5f0.json"}}, {"family": "Cruz", "given": "Julio Eduardo", "initials": "JE"}, {"family": "David", "given": "Daniel", "initials": "D"}, {"family": "David", "given": "Oana A", "initials": "OA"}, {"family": "Defelipe", "given": "Renata Pereira", "initials": "RP"}, {"family": "Elmas", "given": "Pinar", "initials": "P"}, {"family": "Espinosa", "given": "Agust\u00edn", "initials": "A"}, {"family": "Fernandez", "given": "Ana Maria", "initials": "AM", "orcid": "0000-0003-4132-5891", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62a5afa4f51d4eedb88d47f14e79369a.json"}}, {"family": "Fetvadjiev", "given": "Velichko H", "initials": "VH", "orcid": "0000-0002-5475-5121", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d19fbc56230947648979491718129881.json"}}, {"family": "Fetvadjieva", "given": "Stefka", "initials": "S"}, {"family": "Fischer", "given": "Ronald", "initials": "R"}, {"family": "Galdi", "given": "Silvia", "initials": "S", "orcid": "0000-0002-1343-9245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1f426be397e4444ab9e2a9985db301b.json"}}, {"family": "Galindo-Caballero", "given": "Oscar Javier", "initials": "OJ", "orcid": "0000-0003-4603-6415", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a790435cd0b146b19f284104cd63b6fc.json"}}, {"family": "Golovina", "given": "Elena V", "initials": "EV", "orcid": "0000-0003-3053-6706", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5659b410753b4f908cb6b537adbb7678.json"}}, {"family": "Golovina", "given": "Galina M", "initials": "GM", "orcid": "0000-0002-2747-1422", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3331b31e6ff4acdbfc22b032356ba9f.json"}}, {"family": "Gomez-Jacinto", "given": "Luis", "initials": "L"}, {"family": "Graf", "given": "Sylvie", "initials": "S"}, {"family": "Grossmann", "given": "Igor", "initials": "I", "orcid": "0000-0003-2681-3600", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88e68a874f26479e84ddeca2112a1915.json"}}, {"family": "Gul", "given": "Pelin", "initials": "P"}, {"family": "Halama", "given": "Peter", "initials": "P"}, {"family": "Hamamura", "given": "Takeshi", "initials": "T"}, {"family": "Han", "given": "Shihui", "initials": "S"}, {"family": "Hansson", "given": "Lina S", "initials": "LS"}, {"family": "Hitokoto", "given": "Hidefumi", "initials": "H"}, {"family": "H\u0159eb\u00ed\u010dkov\u00e1", "given": "Martina", "initials": "M", "orcid": "0000-0002-8700-1326", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/224b1347d51b471f85e0f77e98166139.json"}}, {"family": "Ilic", "given": "Darinka", "initials": "D"}, {"family": "Johnson", "given": "Jennifer Lee", "initials": "JL"}, {"family": "Kara-Yakoubian", "given": "Mane", "initials": "M"}, {"family": "Karl", "given": "Johannes A", "initials": "JA"}, {"family": "Kim", "given": "Jinseok P", "initials": "JP"}, {"family": "Koh\u00fat", "given": "Michal", "initials": "M"}, {"family": "Lasselin", "given": "Julie", "initials": "J"}, {"family": "Lee", "given": "Hwaryung", "initials": "H"}, {"family": "Li", "given": "Norman P", "initials": "NP"}, {"family": "Mafra", "given": "Anthonieta Looman", "initials": "AL"}, {"family": "Malanchuk", "given": "Oksana", "initials": "O"}, {"family": "Moran", "given": "Simone", "initials": "S", "orcid": "0000-0002-2261-050X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba0b4c98e1bf4aedb45d4cb5e5c93a5c.json"}}, {"family": "Murata", "given": "Asuka", "initials": "A"}, {"family": "Na", "given": "Jinkyung", "initials": "J"}, {"family": "Ndiaye", "given": "Serigne Abdou Lahat", "initials": "SAL"}, {"family": "O", "given": "Jiaqing", "initials": "J"}, {"family": "Onyishi", "given": "Ike E", "initials": "IE"}, {"family": "Pasay-An", "given": "Eddieson", "initials": "E"}, {"family": "Rizwan", "given": "Muhammed", "initials": "M"}, {"family": "Roth", "given": "Eric", "initials": "E"}, {"family": "Salgado", "given": "Sergio", "initials": "S", "orcid": "0000-0003-1398-3416", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b6bf70dfbf74c1a8c23cdfdc6258bd1.json"}}, {"family": "Samoylenko", "given": "Elena S", "initials": "ES", "orcid": "0000-0001-7980-3903", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b10af86df3744498bfe140dcfb5a91c.json"}}, {"family": "Savchenko", "given": "Tatyana N", "initials": "TN"}, {"family": "Sette", "given": "Catarina", "initials": "C"}, {"family": "Sevincer", "given": "A Timur", "initials": "AT"}, {"family": "Skoog", "given": "Eric", "initials": "E"}, {"family": "Stanciu", "given": "Adrian", "initials": "A"}, {"family": "Suh", "given": "Eunkook M", "initials": "EM"}, {"family": "Sznycer", "given": "Daniel", "initials": "D"}, {"family": "Talhelm", "given": "Thomas", "initials": "T", "orcid": "0000-0002-0954-5758", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65d0fc062c0042479749c70085549e24.json"}}, {"family": "Ugwu", "given": "Fabian O", "initials": "FO"}, {"family": "Uskul", "given": "Ayse K", "initials": "AK"}, {"family": "Uz", "given": "Irem", "initials": "I"}, {"family": "Valentova", "given": "Jaroslava Varella", "initials": "JV"}, {"family": "Varella", "given": "Marco Antonio Correa", "initials": "MAC"}, {"family": "Wei", "given": "Liuqing", "initials": "L"}, {"family": "Zambrano", "given": "Danilo", "initials": "D"}, {"family": "Varnum", "given": "Michael E W", "initials": "MEW", "orcid": "0000-0002-2088-6086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05c99a538ea14289988c9a52f9673a37.json"}}], "type": "journal article", "published": "2022-08-16", "journal": {"title": "Sci Data", "issn": "2052-4463", "volume": "9", "issue": "1", "pages": "499", "issn-l": null}, "abstract": "H\ufeffow does psychology vary across human societies? The fundamental social motives framework adopts an evolutionary approach to capture the broad range of human social goals within a taxonomy of ancestrally recurring threats and opportunities. These motives-self-protection, disease avoidance, affiliation, status, mate acquisition, mate retention, and kin care-are high in fitness relevance and everyday salience, yet understudied cross-culturally. Here, we gathered data on these motives in 42 countries (N = 15,915) in two cross-sectional waves, including 19 countries (N = 10,907) for which data were gathered in both waves. Wave 1 was collected from mid-2016 through late 2019 (32 countries, N = 8,998; 3,302 male, 5,585 female; Mage = 24.43, SD = 7.91). Wave 2 was collected from April through November 2020, during the COVID-19 pandemic (29 countries, N = 6,917; 2,249 male, 4,218 female; Mage = 28.59, SD = 11.31). These data can be used to assess differences and similarities in people's fundamental social motives both across and within cultures, at different time points, and in relation to other commonly studied cultural indicators and outcomes.", "doi": "10.1038/s41597-022-01579-w", "pmid": "35974021", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41597-022-01579-w"}], "notes": [], "created": "2022-08-17T10:31:13.999Z", "modified": "2022-08-19T05:24:57.474Z"}, {"entity": "publication", "iuid": "b2c703b7a7ea4ae5a081a00bc6cd263e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b2c703b7a7ea4ae5a081a00bc6cd263e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b2c703b7a7ea4ae5a081a00bc6cd263e"}}, "title": "Symptoms of anxiety and depression during the COVID-19 pandemic in six European countries and Australia - Differences by prior mental disorders and migration status.", "authors": [{"family": "G\u00e9mes", "given": "Katalin", "initials": "K", "orcid": "0000-0003-3335-7850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe866acb6ee744e7a413be9348fd3463.json"}}, {"family": "Bergstr\u00f6m", "given": "Jakob", "initials": "J"}, {"family": "Papola", "given": "Davide", "initials": "D"}, {"family": "Barbui", "given": "Corrado", "initials": "C"}, {"family": "Lam", "given": "Agnes Iok Fong", "initials": "AIF"}, {"family": "Hall", "given": "Brian J", "initials": "BJ"}, {"family": "Seedat", "given": "Soraya", "initials": "S"}, {"family": "Morina", "given": "Naser", "initials": "N"}, {"family": "Quero", "given": "Soledad", "initials": "S"}, {"family": "Campos", "given": "Daniel", "initials": "D"}, {"family": "Pinucci", "given": "Irene", "initials": "I"}, {"family": "Tarsitani", "given": "Lorenzo", "initials": "L"}, {"family": "Deguen", "given": "S\u00e9verine", "initials": "S"}, {"family": "van der Waerden", "given": "Judith", "initials": "J"}, {"family": "Patan\u00e8", "given": "Martina", "initials": "M"}, {"family": "Sijbrandij", "given": "Marit", "initials": "M"}, {"family": "Acart\u00fcrk", "given": "Ceren", "initials": "C"}, {"family": "Burchert", "given": "Sebastian", "initials": "S"}, {"family": "Bryant", "given": "Richard A", "initials": "RA"}, {"family": "Mittendorfer-Rutz", "given": "Ellenor", "initials": "E"}], "type": "journal article", "published": "2022-08-15", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "volume": "311", "pages": "214-223", "issn-l": null}, "abstract": "Little is known about changes of mental health during the COVID-19 pandemic in potentially disadvantaged groups. We investigated changes in anxiety and depression symptoms during the first year of the pandemic in six European countries and Australia by prior mental disorders and migration status.\n\nOverall, 4674 adults answered a web-based survey in May-June 2020 and were followed by three repeated surveys up to February 2021. Information on psychosocial, financial and demographic, living conditions, prior mental disorders, depression and anxiety symptoms during the pandemic and migration status was collected. Weighted general estimation equations modelling was used to investigate the association between prior mental disorders, migration status, and symptoms over time.\n\nMost participants were <40 years old (48%), women (78%) and highly educated (62%). The baseline prevalence of depressive and anxiety symptoms ranged between 19%-45% and 13%-35%, respectively. In most countries, prevalence rates remained unchanged throughout the pandemic and were higher among people with prior mental disorders than without even after adjustment for several factors. We observed interactions between previous mental disorders and symptoms of anxiety or depression over time in two countries. No difference by migration status was noted.\n\nConvenience sampling limits generalizability. Self-assessed symptoms of depression and anxiety might involve some misclassification.\n\nDepression and anxiety symptoms were worse among individuals with prior mental disorders than without, but there was no clear trend of worsening mental health in the observed groups during the observed period.", "doi": "10.1016/j.jad.2022.05.082", "pmid": "35598751", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9119165"}, {"db": "pii", "key": "S0165-0327(22)00596-1"}], "notes": [], "created": "2022-06-21T17:58:19.742Z", "modified": "2023-06-19T14:52:50.464Z"}, {"entity": "publication", "iuid": "62280c2192c346a1ab87f0b00ac6c948", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/62280c2192c346a1ab87f0b00ac6c948.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/62280c2192c346a1ab87f0b00ac6c948"}}, "title": "Poor long-term recovery after critical COVID-19 during 12 months longitudinal follow-up.", "authors": [{"family": "Larsson", "given": "Ing-Marie", "initials": "IM"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Rubertsson", "given": "Sten", "initials": "S"}, {"family": "Wallin", "given": "Ewa", "initials": "E"}], "type": "journal article", "published": "2022-08-15", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "pages": "103311", "issn-l": null}, "abstract": "This study aimed to describe the burden of illness and impact on health and working situation among former intensive care patients treated for COVID-19.\n\nA prospective cohort study was performed at one intensive care unit of a university hospital in Sweden during the first wave of COVID-19 in spring 2020. The burden of illness in health status, cognitive, physical, and psychological outcomes, and working situation were assessed at four and 12 months after discharge from intensive care, using nine validated instruments.\n\nForty-six participants treated for COVID-19 participated in both follow-ups and were included in this study. General fatigue was reported by 37 of 46 participants (82%) at both follow-ups (p = 1.000). For overall health status 28 (61%) participants at the first follow-up and 26 (57%) (p = 0.414) at the second reported lower values than the general population. Cognitive impairment was seen in 22 (52%) participants at four months and in 13 (31%) at 12 months (p = 0.029). The proportion of participants on sick-leave decreased between the first and second follow-up (24% vs 13%, p = 0.025), but the proportion of participants working full-time was almost the same at both follow-ups (35% vs 37%, p = 0.317).\n\nThe burden of illness of patients treated in intensive care due to COVID-19 included cognitive, physical, and psychological impacts. Cognitive functions were improved after 12 months, but no clear improvements could be distinguished in the physical or psychological outcome. Higher burden of illness was associated with inability to return to work.", "doi": "10.1016/j.iccn.2022.103311", "pmid": "36028412", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(22)00114-8"}, {"db": "pmc", "key": "PMC9376301"}], "notes": [], "created": "2022-09-12T19:16:13.070Z", "modified": "2022-09-12T19:16:13.086Z"}, {"entity": "publication", "iuid": "11fd59eaf9764e9a8e6755f71a276a98", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/11fd59eaf9764e9a8e6755f71a276a98.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/11fd59eaf9764e9a8e6755f71a276a98"}}, "title": "Estimates of the Global Burden of COVID-19 and the Value of Broad and Equitable Access to COVID-19 Vaccines.", "authors": [{"family": "Bell", "given": "Eleanor", "initials": "E"}, {"family": "Brassel", "given": "Simon", "initials": "S"}, {"family": "Oliver", "given": "Edward", "initials": "E"}, {"family": "Schirrmacher", "given": "Hannah", "initials": "H"}, {"family": "Arnetorp", "given": "Sofie", "initials": "S"}, {"family": "Berg", "given": "Katja", "initials": "K"}, {"family": "Darroch-Thompson", "given": "Duncan", "initials": "D"}, {"family": "Pohja-Hutchison", "given": "Paula", "initials": "P"}, {"family": "Mungall", "given": "Bruce", "initials": "B", "orcid": "0000-0002-6772-1633", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/000d4730d4874855be8d266b84e473d5.json"}}, {"family": "Carroll", "given": "Stuart", "initials": "S"}, {"family": "Postma", "given": "Maarten", "initials": "M"}, {"family": "Steuten", "given": "Lotte", "initials": "L"}], "type": "journal article", "published": "2022-08-15", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "The objectives of this research were to produce a macro-level overview of the global COVID-19 burden and estimate the value of access to COVID-19 vaccines. A targeted literature review collated evidence of the burden. Linear modelling and data analysis estimated the health and economic effects of COVID-19 vaccines delivered in 2021, and whether additional value could have been achieved with broader and more equitable access. By 1 December 2020, there had been an estimated 17 million excess deaths due to COVID-19. Low-income countries allocated more than 30% of their healthcare budgets to COVID-19, compared to 8% in high-income countries. All country income groups experienced gross domestic product (GDP) growth lower than predicted in 2020. If all 92 countries eligible for COVAX Advance Market Committee (AMC), access had reached 40% vaccination coverage in 2021, 120% more excess deaths would have been averted, equivalent to USD 5 billion (109) in savings to healthcare systems. Every USD spent by advanced economies on vaccinations for less advanced economies averted USD 28 of economic losses in advanced economies and USD 29 in less advanced economies. The cost to high-income countries when not all countries are vaccinated far outweighs the cost of manufacturing and distributing vaccines globally.", "doi": "10.3390/vaccines10081320", "pmid": "36016208", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "vaccines10081320"}, {"db": "pmc", "key": "PMC9414589"}], "notes": [], "created": "2022-09-12T19:12:59.235Z", "modified": "2022-09-12T19:12:59.286Z"}, {"entity": "publication", "iuid": "6ec8cb2dc00147058afc7de3e5220305", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ec8cb2dc00147058afc7de3e5220305.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ec8cb2dc00147058afc7de3e5220305"}}, "title": "ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19.", "authors": [{"family": "Pietzner", "given": "Maik", "initials": "M", "orcid": "0000-0003-3437-9963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae2392fc827747cea946168e9ab60117.json"}}, {"family": "Chua", "given": "Robert Lorenz", "initials": "RL"}, {"family": "Wheeler", "given": "Eleanor", "initials": "E", "orcid": "0000-0002-8616-6444", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd3b1a02da1d4d2eb7ac766ba6f8bc3a.json"}}, {"family": "Jechow", "given": "Katharina", "initials": "K"}, {"family": "Willett", "given": "Julian D S", "initials": "JDS"}, {"family": "Radbruch", "given": "Helena", "initials": "H", "orcid": "0000-0001-6941-3397", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2079cbe1c9644d808083075882dfaadf.json"}}, {"family": "Trump", "given": "Saskia", "initials": "S"}, {"family": "Heidecker", "given": "Bettina", "initials": "B"}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ee1510080704cf6a2a6972deb94123f.json"}}, {"family": "Heppner", "given": "Frank L", "initials": "FL", "orcid": "0000-0001-9816-8917", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2b4021b116b445b9a1cd7cf7d82b3ba.json"}}, {"family": "Eils", "given": "Roland", "initials": "R"}, {"family": "Mall", "given": "Marcus A", "initials": "MA", "orcid": "0000-0002-4057-2199", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02b1007277d345789ac961a0d9d0eadc.json"}}, {"family": "Richards", "given": "J Brent", "initials": "JB", "orcid": "0000-0002-3746-9086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8994152547ee4765b1653b834c52a21a.json"}}, {"family": "Sander", "given": "Leif-Erik", "initials": "LE", "orcid": "0000-0002-0476-9947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36c4c59d112a4a2dbdc313dcd69c9702.json"}}, {"family": "Lehmann", "given": "Irina", "initials": "I"}, {"family": "Lukassen", "given": "S\u00f6ren", "initials": "S", "orcid": "0000-0001-7045-6327", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f138415d18c54a29a45151d2503c7166.json"}}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0003-1422-2993", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd19f9bbc2994ab3aef6731904c05dd7.json"}}, {"family": "Conrad", "given": "Christian", "initials": "C", "orcid": "0000-0001-7036-342X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee26a84058fe4316a74e87de6021b51b.json"}}, {"family": "Langenberg", "given": "Claudia", "initials": "C", "orcid": "0000-0002-5017-7344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa75a577048f439f9804254975b25c9d.json"}}], "type": "journal article", "published": "2022-08-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "4484", "issn-l": "2041-1723"}, "abstract": "Despite two years of intense global research activity, host genetic factors that predispose to a poorer prognosis of COVID-19 infection remain poorly understood. Here, we prioritise eight robust (e.g., ELF5) or suggestive but unreported (e.g., RAB2A) candidate protein mediators of COVID-19 outcomes by integrating results from the COVID-19 Host Genetics Initiative with population-based plasma proteomics using statistical colocalisation. The transcription factor ELF5 (ELF5) shows robust and directionally consistent associations across different outcome definitions, including a >4-fold higher risk (odds ratio: 4.88; 95%-CI: 2.47-9.63; p-value < 5.0 \u00d7 10-6) for severe COVID-19 per 1 s.d. higher genetically predicted plasma ELF5. We show that ELF5 is specifically expressed in epithelial cells of the respiratory system, such as secretory and alveolar type 2 cells, using single-cell RNA sequencing and immunohistochemistry. These cells are also likely targets of SARS-CoV-2 by colocalisation with key host factors, including ACE2 and TMPRSS2. In summary, large-scale human genetic studies together with gene expression at single-cell resolution highlight ELF5 as a risk gene for severe COVID-19, supporting a role of epithelial cells of the respiratory system in the adverse host response to SARS-CoV-2.", "doi": "10.1038/s41467-022-31999-6", "pmid": "35970849", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-022-31999-6"}], "notes": [], "created": "2022-08-16T15:36:49.489Z", "modified": "2022-08-16T15:36:49.829Z"}, {"entity": "publication", "iuid": "6f8eeeda1af643599fc32e33819ababb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f8eeeda1af643599fc32e33819ababb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f8eeeda1af643599fc32e33819ababb"}}, "title": "COVID-19 and Risk of Oxygen-Dependent Chronic Respiratory Failure: A National Cohort Study.", "authors": [{"family": "Sundh", "given": "Josefin", "initials": "J", "orcid": "0000-0003-1926-8464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0994c494df3b4955bedb00606add70d6.json"}}, {"family": "Ekstr\u00f6m", "given": "Magnus", "initials": "M", "orcid": "0000-0002-7227-5113", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ba0a61aa5e54bd6be6f29d7b5b02033.json"}}, {"family": "Palm", "given": "Andreas", "initials": "A", "orcid": "0000-0002-0590-0417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7f49fdf5aee42af9988590a914afb4f.json"}}, {"family": "Ljunggren", "given": "Mirjam", "initials": "M", "orcid": "0000-0002-8486-6746", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ff050327b5f4bc6834723a8244989e9.json"}}, {"family": "Emilsson", "given": "\u00d6ssur Ingi", "initials": "\u00d6I", "orcid": "0000-0002-7199-8491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/269f70619f6a4880b4f45047f43ab7e1.json"}}, {"family": "Grote", "given": "Ludger", "initials": "L", "orcid": "0000-0002-7405-1682", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8172ded15f0b4332b7ab54d7f131b87a.json"}}, {"family": "Cajander", "given": "Sara", "initials": "S", "orcid": "0000-0003-3921-4244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51683903983f4778bfda99da291f2446.json"}}, {"family": "Li", "given": "Huiqi", "initials": "H", "orcid": "0000-0002-1127-0829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e3bd3ff6b4e4f448f9332081da1dc29.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}], "type": "letter", "published": "2022-08-15", "journal": {"title": "Am J Respir Crit Care Med", "issn": "1535-4970", "issn-l": "1073-449X", "volume": "206", "issue": "4", "pages": "506-509"}, "abstract": null, "doi": "10.1164/rccm.202202-0323LE", "pmid": "35549847", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-01-13T09:57:49.375Z", "modified": "2023-01-13T09:59:02.287Z"}, {"entity": "publication", "iuid": "69915d78ba4142779dd2463e72168f57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69915d78ba4142779dd2463e72168f57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69915d78ba4142779dd2463e72168f57"}}, "title": "COVAD survey 2 long-term outcomes: unmet need and protocol.", "authors": [{"family": "Fazal", "given": "Zoha Zahid", "initials": "ZZ", "orcid": "0000-0003-1576-724X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ca989a85bcfc451285f65a09cc2239a7.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Ravichandran", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-0986-8354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2e6226ae5e7427fbf52e180dd14e28f.json"}}, {"family": "Kardes", "given": "Sinan", "initials": "S", "orcid": "0000-0002-6311-8634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2900c3ca00da476a8914574384a3c9c2.json"}}, {"family": "Kim", "given": "Minchul", "initials": "M", "orcid": "0000-0001-9737-6255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd2952c6167b4733bfbce019a162b310.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Selva-O'Callaghan", "given": "Albert", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0003-2823-9761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef3e202c049b44a2a5e045bac90a393a.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Guti\u00e9rrez", "given": "Carlos-Enrique Toro", "initials": "CT"}, {"family": "Caballero-Uribe", "given": "Carlo Vinicio", "initials": "CV"}, {"family": "Dey", "given": "Dzifa", "initials": "D"}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "COVAD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-08-14", "journal": {"title": "Rheumatol Int", "issn": "1437-160X", "issn-l": null}, "abstract": "Vaccine hesitancy is considered a major barrier to achieving herd immunity against COVID-19. While multiple alternative and synergistic approaches including heterologous vaccination, booster doses, and antiviral drugs have been developed, equitable vaccine uptake remains the foremost strategy to manage pandemic. Although none of the currently approved vaccines are live-attenuated, several reports of disease flares, waning protection, and acute-onset syndromes have emerged as short-term adverse events after vaccination. Hence, scientific literature falls short when discussing potential long-term effects in vulnerable cohorts. The COVAD-2 survey follows on from the baseline COVAD-1 survey with the aim to collect patient-reported data on the long-term safety and tolerability of COVID-19 vaccines in immune modulation. The e-survey has been extensively pilot-tested and validated with translations into multiple languages. Anticipated results will help improve vaccination efforts and reduce the imminent risks of COVID-19 infection, especially in understudied vulnerable groups.", "doi": "10.1007/s00296-022-05157-6", "pmid": "35964271", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00296-022-05157-6"}], "notes": [], "created": "2022-08-16T15:38:25.072Z", "modified": "2022-08-16T15:38:25.387Z"}, {"entity": "publication", "iuid": "28fe8f3c19a34e55be3411e073c704a5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/28fe8f3c19a34e55be3411e073c704a5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/28fe8f3c19a34e55be3411e073c704a5"}}, "title": "Formation of eicosanoids and other oxylipins in human macrophages.", "authors": [{"family": "Radmark", "given": "Olof", "initials": "O"}], "type": "journal article", "published": "2022-08-13", "journal": {"title": "Biochem Pharmacol", "issn": "1873-2968", "pages": "115210", "issn-l": null}, "abstract": "In this review it is attempted to summarize current studies about formation of eicosanoids and other oxylipins in different human macrophages. There are several reports on M1 and M2 cells, also other phenotypes have been described. The eicosanoids formed in the largest amounts are the COX products TxB2 and PGE2. Thus shortlived bioactive TxA2 is a dominating product both in M1- and in M2-lineages, one exception seems to be MGM-CSF, TGF\u03b2 cells. 5-LOX products are produced in both M1 and M2 macrophages, as well as in not fully polarized cells of both lineages. MM-CSF as well as M2 macrophages produced LTC4 more readily compared to M1 lineage cells. In MGM-CSF, TGF\u03b2 cells LTB4 is a major eicosanoid, in line with high expression of LTA4 hydrolase. Recent reports described increased formation of leukotrienes in macrophages subjected to trained immunity with inflammatory transcriptional reprogramming. Also in macrophages derived from monocytes collected from post-COVID-19 patients. 15-LOX-1 is strongly upregulated in CD206+ M2 cells (M2a), differentiated in presence of IL-4. These macrophages also express 15-LOX-2. In incubations with pathogenic E. coli as well as other stimuli 15(S)-HETE and 17(S)-HDHA were major oxylipins formed. Also, the SPM precursor 5,15-diHETE and the SPM RvD5 were produced in considerable amounts, while other SPMs were less abundant. In M2 macrophages incubated with E. coli or S. aureus the cytosolic 15-LOX-1 enzyme accumulated to punctuate structures in a Ca2+ dependent manner with a relatively slow time course, leading to formation of mediators from endogenous substrate. Chalcones, flavone-like anti-inflammatory natural products, induced translocation of 15-LOX-1 in M2 cells, with high formation of 15-LOX derived oxylipins.", "doi": "10.1016/j.bcp.2022.115210", "pmid": "35973581", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0006-2952(22)00304-5"}], "notes": [], "created": "2022-08-17T10:32:10.568Z", "modified": "2022-08-19T05:25:17.438Z"}, {"entity": "publication", "iuid": "4b8dde812e5f412fa4721dd0055a0926", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b8dde812e5f412fa4721dd0055a0926.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b8dde812e5f412fa4721dd0055a0926"}}, "title": "Association between use of novel glucose-lowering drugs and COVID-19 hospitalization and death in patients with type 2 diabetes: a nationwide registry analysis.", "authors": [{"family": "Ferrannini", "given": "Giulia", "initials": "G", "orcid": "0000-0002-0318-7435", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/378055a26c2c4adaa9068e96f58657fd.json"}}, {"family": "Lund", "given": "Lars H", "initials": "LH", "orcid": "0000-0003-1411-4482", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d9e6ace88b04d23ad1778c4c9d9a425.json"}}, {"family": "Benson", "given": "Lina", "initials": "L"}, {"family": "Rizzo", "given": "Manfredi", "initials": "M", "orcid": "0000-0002-9549-8504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d888593722ae4ba2b12a04effd67eaff.json"}}, {"family": "Almahmeed", "given": "Wael", "initials": "W"}, {"family": "Rosano", "given": "Giuseppe M C", "initials": "GMC"}, {"family": "Savarese", "given": "Gianluigi", "initials": "G"}, {"family": "Cosentino", "given": "Francesco", "initials": "F", "orcid": "0000-0002-6967-5685", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/992ccaa4fa4341379b1932bc0b6d1193.json"}}], "type": "journal article", "published": "2022-08-13", "journal": {"title": "Eur Heart J Cardiovasc Pharmacother", "issn": "2055-6845", "issn-l": "2055-6837"}, "abstract": "Type 2 diabetes (T2DM) in patients with coronavirus disease-19 (COVID-19) is associated with worse prognosis. We separately investigated the associations between the use of sodium-glucose cotransporter 2 inhibitors (SGLT2i), glucagon-like peptide-1 receptor agonists (GLP-1 RA) and dipeptidyl peptidase-4 inhibitors (DPP-4i), and the risk of COVID-19 hospitalization and death.\n\nPatients with T2DM registered in the Swedish National Patient Registry and alive on 1st February 2020 were included. \"Incident severe COVID-19\" was defined as the first hospitalization and/or death from COVID-19. A modified Poisson regression approach was applied to a 1:1 propensity score-matched population receiving vs. not receiving SGLT2i, GLP-1 RA and DPP-4i to analyze the associations between their use and I) incident severe COVID-19, II) risk of 30-day mortality in patients hospitalized for COVID-19.Among 344,413 patients, 39,172 (11%) were treated with SGLT2i, 34,290 (10%) with GLP-1 RA and 53,044 (15%) with DPP-4i; 9,538 (2.8%) had incident severe COVID-19 by 15th May 2021. SGLT2i and DPP-4i were associated with a 10% and 11% higher risk of incident severe COVID-19, respectively, whereas there was no association for GLP-1 RA. DPP-4i were also associated with a 10% higher 30-day mortality in patients hospitalized for COVID-19, whereas there was no association for SGLT2i and GLP-1 RA.\n\nSGLT2i and DPP-4i use was associated with higher risk of incident severe COVID-19. DPP-4i use was associated with higher 30-day mortality in patients with COVID-19, whereas SGLT2i use was not. No increased risk for any outcome was observed with GLP-1 RA.", "doi": "10.1093/ehjcvp/pvac044", "pmid": "35963647", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6665927"}], "notes": [], "created": "2022-08-16T15:38:39.733Z", "modified": "2022-08-16T15:38:39.887Z"}, {"entity": "publication", "iuid": "8c8ce2d05d554dc48bcb8c348f5b65f3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c8ce2d05d554dc48bcb8c348f5b65f3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c8ce2d05d554dc48bcb8c348f5b65f3"}}, "title": "Dispositional optimism and all-cause mortality after esophageal cancer surgery: a nationwide population-based cohort study.", "authors": [{"family": "Liu", "given": "Yangjun", "initials": "Y"}, {"family": "Pettersson", "given": "Erik", "initials": "E"}, {"family": "Schandl", "given": "Anna", "initials": "A"}, {"family": "Markar", "given": "Sheraz", "initials": "S"}, {"family": "Johar", "given": "Asif", "initials": "A"}, {"family": "Lagergren", "given": "Pernilla", "initials": "P"}], "type": "journal article", "published": "2022-08-11", "journal": {"title": "Support Care Cancer", "issn": "1433-7339", "issn-l": null}, "abstract": "To examine the association between dispositional optimism and all-cause mortality after esophageal cancer surgery and whether pathological tumor stage and the COVID-19 pandemic modified this association.\n\nThis nationwide, population-based prospective cohort study included 335 patients undergoing esophageal cancer surgery in Sweden between January 1, 2013, and December 31, 2019. Dispositional optimism was measured 1 year post-surgery using Life Orientation Test-Revised (LOT-R). A higher LOT-R sum score represents higher dispositional optimism. Mortality information was obtained from the Swedish Register of the Total Population. All patients were followed up until death or until December 31, 2020, whichever occurred first. Cox regression with adjustments for confounders was used.\n\nThe median follow-up was 20.8 months, during which 125 (37.3%) patients died. Among the included 335 patients, 219 (65.4%) patients had tumor pathologically staged Tis-II, and 300 (89.6%) patients entered the cohort before the COVID-19 pandemic. Both tumor stage and the COVID-19 pandemic were effect modifiers. For each unit increase in LOT-R sum score, the risk of all-cause mortality decreased by 11% (HR 0.89, 95% CI 0.81 to 0.98) among patients with tumor staged Tis-II before the COVID-19 pandemic. This association was non-significant in patients with tumor staged III-IV (HR 0.99, 95% CI 0.92 to 1.07) and during the COVID-19 pandemic (HR 1.08, 95% CI 0.94 to 1.25).\n\nAssessing dispositional optimism may help predict postoperative survival, especially for patients with early and intermediate esophageal cancer. Increasing dispositional optimism might be a potential intervention target to improve survival after esophageal cancer surgery.", "doi": "10.1007/s00520-022-07311-z", "pmid": "35953730", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00520-022-07311-z"}, {"db": "pmc", "key": "PMC9371627"}], "notes": [], "created": "2022-08-16T15:43:14.451Z", "modified": "2022-08-16T15:43:28.384Z"}, {"entity": "publication", "iuid": "d429910ab03c4043b50f3a1a01eb6816", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d429910ab03c4043b50f3a1a01eb6816.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d429910ab03c4043b50f3a1a01eb6816"}}, "title": "Children in the household and risk of severe COVID-19 during the first three waves of the pandemic: a prospective registry-based cohort study of 1.5 million Swedish men.", "authors": [{"family": "Af Geijerstam", "given": "Agnes", "initials": "A", "orcid": "0000-0002-0897-6548", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ab4ce35a27d446da006cd3aece117c2.json"}}, {"family": "Mehlig", "given": "Kirsten", "initials": "K"}, {"family": "Hunsberger", "given": "Monica", "initials": "M"}, {"family": "\u00c5berg", "given": "Maria", "initials": "M"}, {"family": "Lissner", "given": "Lauren", "initials": "L"}], "type": "journal article", "published": "2022-08-11", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "8", "pages": "e063640", "issn-l": "2044-6055"}, "abstract": "To investigate whether Swedish men living with children had elevated risk for severe COVID-19 or infection with SARS-CoV-2 during the first three waves of the pandemic.\n\nProspective registry-based cohort study.\n\n1 557 061 Swedish men undergoing military conscription between 1968 and 2005 at a mean age of 18.3 (SD 0.73) years.\n\nInfection with SARS-CoV-2 and hospitalisation due to COVID-19 from March 2020 to September 2021.\n\nThere was a protective association between preschool children at home and hospitalisation due to COVID-19 during the first and third waves compared with only older or no children at all, with ORs (95% CIs) 0.63 (0.46 to 0.88) and 0.75 (0.68 to 0.94) respectively. No association was observed for living with children 6-12 years old, but for 13-17 years old, the risk increased. Age in 2020 did not explain these associations. Further adjustment for socioeconomic and health factors did not attenuate the results. Exposure to preschool children also had a protective association with testing positive with SARS-CoV-2, with or without hospitalisation, OR=0.91 (95% CI 0.89 to 0.93), while living with children of other ages was associated with increased odds of infection.\n\nCohabiting with preschool children was associated with reduced risk for severe COVID-19. Living with school-age children between 6 and 12 years had no association with severe COVID-19, but sharing the household with teenagers and young adults was associated with elevated risk. Our results are of special interest since preschools and compulsory schools (age 6-15 years) in Sweden did not close in 2020.", "doi": "10.1136/bmjopen-2022-063640", "pmid": "35953248", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2022-063640"}], "notes": [], "created": "2022-08-12T08:29:46.779Z", "modified": "2022-08-12T08:30:25.309Z"}, {"entity": "publication", "iuid": "4ffb1f30bb7b4f93a2b968c49c876566", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ffb1f30bb7b4f93a2b968c49c876566.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ffb1f30bb7b4f93a2b968c49c876566"}}, "title": "A Worldwide Survey of Activities and Practices in Clinical Islet of Langerhans Transplantation.", "authors": [{"family": "Berney", "given": "Thierry", "initials": "T"}, {"family": "Andres", "given": "Axel", "initials": "A"}, {"family": "Bellin", "given": "Melena D", "initials": "MD"}, {"family": "de Koning", "given": "Eelco J P", "initials": "EJP"}, {"family": "Johnson", "given": "Paul R V", "initials": "PRV"}, {"family": "Kay", "given": "Thomas W H", "initials": "TWH"}, {"family": "Lundgren", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Rickels", "given": "Michael R", "initials": "MR"}, {"family": "Scholz", "given": "Hanne", "initials": "H"}, {"family": "Stock", "given": "Peter G", "initials": "PG"}, {"family": "White", "given": "Steve", "initials": "S"}, {"family": "International Islet Transplant Centers", "given": "", "initials": ""}], "type": "journal article", "published": "2022-08-11", "journal": {"title": "Transpl Int", "issn": "1432-2277", "volume": "35", "pages": "10507", "issn-l": null}, "abstract": "A global online survey was administered to 69 islet transplantation programs, covering 84 centers and 5 networks. The survey addressed questions on program organization and activity in the 2000-2020 period, including impact on activity of national health care coverage policies. We obtained full data from 55 institutions or networks worldwide and basic activity data from 6 centers. Additional data were obtained from alternative sources. A total of 94 institutions and 5 networks was identified as having performed islet allotransplantation. 4,365 islet allotransplants (2,608 in Europe, 1,475 in North America, 135 in Asia, 119 in Oceania, 28 in South America) were reported in 2,170 patients in the survey period. From 15 centers active at the start of the study period, the number of simultaneously active islet centers peaked at 54, to progressively decrease to 26 having performed islet allotransplants in 2020. Notably, only 16 centers/networks have done >100 islet allotransplants in the survey period. Types of transplants performed differed notably between North America and the rest of the world, in particular with respect to the near-absence of simultaneous islet-kidney transplantation. Absence of heath care coverage has significantly hampered transplant activity in the past years and the COVID-19 pandemic in 2020.", "doi": "10.3389/ti.2022.10507", "pmid": "36033644", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10507"}, {"db": "pmc", "key": "PMC9402897"}], "notes": [], "created": "2022-10-07T12:44:10.197Z", "modified": "2022-10-07T12:44:10.210Z"}, {"entity": "publication", "iuid": "d9754f165def4dd7a095cb943ff195d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d9754f165def4dd7a095cb943ff195d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d9754f165def4dd7a095cb943ff195d5"}}, "title": "Lung perfusion disturbances in non-hospitalized post-COVID with dyspnea - An MRI feasibility study.", "authors": [{"family": "Yu", "given": "Jimmy", "initials": "J", "orcid": "0000-0002-7744-3251", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed9b255a526c48b8977e46a0c3931ce3.json"}}, {"family": "Granberg", "given": "Tobias", "initials": "T", "orcid": "0000-0001-6700-1022", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9650681881d442895c1c60fdb49677e.json"}}, {"family": "Shams", "given": "Roya", "initials": "R"}, {"family": "Petersson", "given": "Sven", "initials": "S"}, {"family": "Sk\u00f6ld", "given": "Magnus", "initials": "M"}, {"family": "Nyr\u00e9n", "given": "Sven", "initials": "S"}, {"family": "Lundberg", "given": "Johan", "initials": "J", "orcid": "0000-0003-2379-8695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/488ece97feee4422994105a3b4c05e94.json"}}], "type": "journal article", "published": "2022-08-10", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null}, "abstract": "Dyspnea is common after COVID-19. Though the underlying mechanisms are largely unknown, lung perfusion abnormalities could contribute to lingering dyspnea.\n\nTo detect pulmonary perfusion disturbances in non-hospitalized individuals with post-COVID condition and persistent dyspnea 4-13 months after the disease onset.\n\nIndividuals with dyspnea and matched healthy controls were recruited for dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), a six-minute walk test, and an assessment of dyspnea. The DCE-MRI was quantified using two parametric values: mean time-to-peak (TTP) and TTP ratio, reflecting the total lung perfusion resistance and the fraction of lung with delayed perfusion, respectively.\n\nTwenty-eight persons with persistent dyspnea (mean age 46.5\u00b18.0 years, 75% women) and 22 controls (mean age 44.1\u00b110.8 years, 73% women) were included. There was no systematic sex difference in dyspnea. The post-COVID group had no focal perfusion deficits but had higher mean pulmonary TTP (0.43\u00b10.04 vs. 0.41\u00b10.03, P = 0.011) and TTP ratio (0.096\u00b10.052 vs. 0.068\u00b10.027, P = 0.032). Post-COVID males had the highest mean TTP 0.47\u00b10.02 and TTP ratio of 0.160\u00b10.039; compared to male controls and post-COVID females (P = 0.001 and P<0.001 respectively). Correlations between dyspnea and perfusion parameters were demonstrated in males (r = 0.83, P<0.001 for mean TTP; r = 0.76, P = 0.003 for TTP ratio), but not in females.\n\nDCE-MRI demonstrated late contrast bolus arrival in males with post-COVID dyspnea, suggestive of primary vascular lesions or secondary effects of hypoxic vasoconstriction. Since this effect was not regularly observed in female patients, our findings suggest sex differences in the mechanisms underlying post-COVID dyspnea, which warrants further investigation in dedicated trials. This article is protected by copyright. All rights reserved.", "doi": "10.1111/joim.13558", "pmid": "35946904", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-11T11:48:35.115Z", "modified": "2022-08-11T11:48:49.758Z"}, {"entity": "publication", "iuid": "1b8ce8c8a35543d9aaa04b01b5220449", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b8ce8c8a35543d9aaa04b01b5220449.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b8ce8c8a35543d9aaa04b01b5220449"}}, "title": "Employees Perception of Organizational Crises and Their Reactions to Them - A Norwegian Organizational Case Study.", "authors": [{"family": "S\u00f8rensen", "given": "Jarle L\u00f8we", "initials": "JL"}, {"family": "Ranse", "given": "Jamie", "initials": "J"}, {"family": "Gray", "given": "Lesley", "initials": "L"}, {"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}, {"family": "Hertelendy", "given": "Attila J", "initials": "AJ"}], "type": "journal article", "published": "2022-08-10", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "13", "pages": "818422", "issn-l": "1664-1078"}, "abstract": "Organizational sensemaking is crucial for resource planning and crisis management since facing complex strategic problems that exceed their capacity and ability, such as crises, forces organizations to engage in inter-organizational collaboration, which leads to obtaining individual and diverse perspectives to comprehend the issues and find solutions. This online qualitative survey study examines how Norwegian Sea Rescue Society employees perceived the concept of an organizational crisis and how they sensed their co-workers react to it. The scope was the ongoing COVID-19 pandemic, a global event affecting all countries and organizations and responding similarly globally. Data were collected during the Fall of 2020. The instrument of choice was the Internal Crisis Management and Crisis Communication survey (ICMCC). The results showed that the overall sample strongly believed in their organization's overall resilience level. However, a somewhat vague understanding of roles and responsibilities in a crisis where detected, together with some signs of informal communication, rumor spreading, misunderstanding, frustration, and insecurity. This study contributes to the academic field of organizational research, hence crisis management and sensemaking, and could be valuable to managers and decision-makers across sectors. Increased knowledge about how employees react to a crisis may help optimize internal crisis management planning and utilize robust mitigation and response strategies.", "doi": "10.3389/fpsyg.2022.818422", "pmid": "36033100", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9400917"}], "notes": [], "created": "2022-10-07T12:42:32.862Z", "modified": "2022-10-07T12:42:46.047Z"}, {"entity": "publication", "iuid": "bbee8ac14a4647fa850d618ac85e8671", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bbee8ac14a4647fa850d618ac85e8671.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bbee8ac14a4647fa850d618ac85e8671"}}, "title": "Predictors of post-COVID-19 and the impact of persistent symptoms in non-hospitalized patients 12 months after COVID-19, with a focus on work ability.", "authors": [{"family": "Kisiel", "given": "Marta A", "initials": "MA"}, {"family": "Janols", "given": "Helena", "initials": "H"}, {"family": "Nordqvist", "given": "Tobias", "initials": "T"}, {"family": "Bergquist", "given": "Jonas", "initials": "J"}, {"family": "Hagfeldt", "given": "Simone", "initials": "S"}, {"family": "Malinovschi", "given": "Andrei", "initials": "A"}, {"family": "Svartengren", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2022-08-09", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "volume": "127", "issn-l": "0300-9734"}, "abstract": "Better knowledge of long-term symptoms following coronavirus disease 2019 (COVID-19), the so-called post-COVID-19, in non-hospitalized patients is needed. The aim of this study was to study persisent symptoms up to 12 months after COVID-19 in non-hospitalized patients and their impact on work ability. We also investigated predictors of persistent symptoms.\n\nThis study encompassed non-hospitalized adult subjects with a COVID-19 infection confirmed via positive nasopharyngeal swab polymerase chain reaction test during the first wave of the pandemic in Uppsala, Sweden. In total, 566 subjects were sent a survey via e-mail or post with an invitation to participate in the survey 12 months post-diagnosis. The majority of subjects were healthcare workers, as this group was prioritized for testing.\n\nA total of 366 subjects responded, with 47% reporting persistent symptoms 12 months after their COVID-19 diagnosis. The most commonly reported symptoms at this time were impaired sense of smell and/or taste and fatigue. Among the predictors of persistent symptoms were being born abroad, lower physical fitness compared with peers before COVID-19, body mass index >25 kg/m2, cooccurrence of hypertension and chronic pain, and having more than seven of the general COVID-19 symptoms at the onset. Respondents with symptoms after 12 months self-reported negatively about their general health and work ability.\n\nThis study indicated that many people who had mild COVID-19 might have a variety of long-term symptoms. It highlights the importance of considering work ability after mild COVID-19.", "doi": "10.48101/ujms.v127.8794", "pmid": "35991464", "labels": {"Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "8794"}, {"db": "pmc", "key": "PMC9383047"}], "notes": [], "created": "2022-09-12T18:51:48.050Z", "modified": "2022-09-12T18:51:48.079Z"}, {"entity": "publication", "iuid": "5b708890ca7a417f9358dc27e7737fd6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5b708890ca7a417f9358dc27e7737fd6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5b708890ca7a417f9358dc27e7737fd6"}}, "title": "Fear of COVID-19 Among Patients with Inflammatory Bowel Disease as Compared to Patients with Other Gastrointestinal Conditions.", "authors": [{"family": "Lo", "given": "Bobby", "initials": "B"}, {"family": "Barreiro-de Acosta", "given": "Manuel", "initials": "M"}, {"family": "Bernstein", "given": "Charles N", "initials": "CN"}, {"family": "Burisch", "given": "Johan", "initials": "J"}, {"family": "Ferreira", "given": "Nuno", "initials": "N"}, {"family": "Gearry", "given": "Richard B", "initials": "RB"}, {"family": "Mikocka-Walus", "given": "Antonina", "initials": "A"}, {"family": "Mokrowiecka", "given": "Anna", "initials": "A"}, {"family": "Trindade", "given": "In\u00eas A", "initials": "IA"}, {"family": "Knowles", "given": "Simon R", "initials": "SR"}], "type": "journal article", "published": "2022-08-09", "journal": {"title": "Turk J Gastroenterol", "issn": "2148-5607", "issn-l": null}, "abstract": "Although several studies have reported the impact of fears relating to coronavirus-19 on several chronic illnesses, there are few studies focused on gastrointestinal conditions. Therefore, the aim of this study was to compare the fear of coronavirus-19 in patients with inflammatory bowel disease to other gastrointestinal conditions and how the fear of COVID-19 manifests across different demographical backgrounds among inflammatory bowel disease respondents.\n\nParticipants with gastrointestinal conditions (age \u2265 18) were recruited from 27 countries. Demographic, clinical, and psycho- social information was collected. An adapted scale for inflammatory bowel disease patients measuring the fear of coronavirus-19 and gastrointestinal-specific fear of coronavirus-19 was used.\n\nIn 831 participants (312 inflammatory bowel disease), only significant increases in gastrointestinal-fear of coronavirus-19 were found in between inflammatory bowel disease and other gastrointestinal conditions (mean [standard deviation]: 13.5 [5.5] vs 10.9 [5.0], P < .01). Among inflammatory bowel disease respondents, persons on sick leave had significantly more fear of coronavirus-19 than those employed (median [IQR], 31.0 [28.5-39.5] vs 26.0 [20.0-33.0], P = .035) and significantly more gastrointestinal-fear of coro- navirus-19 compared to the employed (18.0 [14.5-22.0] vs 13.0 [9.0-17.0], P = .033) or respondents outside of the labor market (12.0 [7.0-16.0], P = .022). Persons living in a rural setting had significantly more fear of coronavirus-19 compared to persons living in regional setting (29.5 [22.0-37.8] vs 25.0 [20.0-31.3], P = .007) and gastrointestinal-fear of coronavirus-19 (15.0 [11.0-19.8] vs 12.0 [9.0-16.0], P = .02).\n\nRespondents with inflammatory bowel disease are more afraid of coronavirus-19 regarding their disease; especially, per- sons on sick leave or persons living in a rural setting. This should be taken into consideration to personalize the support that health care providers can offer in mitigating fear related to coronavirus-19.", "doi": "10.5152/tjg.2022.21774", "pmid": "35943147", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-11T11:49:37.856Z", "modified": "2022-08-11T11:49:37.892Z"}, {"entity": "publication", "iuid": "6a5ff6060a664312acc7a73a2682bba6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a5ff6060a664312acc7a73a2682bba6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a5ff6060a664312acc7a73a2682bba6"}}, "title": "Ethnic, racial and regional inequalities in access to COVID-19 vaccine, testing and hospitalization: Implications for eradication of the pandemic.", "authors": [{"family": "Ahlberg", "given": "Beth Maina", "initials": "BM"}, {"family": "Bradby", "given": "Hannah", "initials": "H"}], "type": "journal article", "published": "2022-08-09", "journal": {"title": "Front Sociol", "issn": "2297-7775", "volume": "7", "pages": "809090", "issn-l": null}, "abstract": "The COVID-19 pandemic has made visible inequalities as exemplified by unequal access to COVID-19 vaccine across and within countries; inequalities that are also apparent in rates of testing, disease, hospitalization and death from COVID-19 along class, ethnic and racial lines. For a global pandemic such as the COVID-19 to be effectively addressed, there is a need to reflect on the entrenched and structural inequalities within and between countries. While many countries in the global north have acquired more vaccines than they may need, in the global south many have very limited access. While countries in the global north had largely vaccinated their populations by 2022, those in the global south may not even complete vaccinating 70% of their population to enable them reach the so-called herd immunity by 2024. Even in the global north where vaccines are available, ethnic, racialized and poor working classes are disproportionately affected in terms of disproportionately low rates of infection and death. This paper explores the socio-economic and political structural factors that have created and maintain these disparities. In particular we sketch the role of neoliberal developments in deregulating and financializing the system, vaccine hoarding, patent protection and how this contributes to maintaining and widening disparities in access to COVID-19 vaccine and medication.", "doi": "10.3389/fsoc.2022.809090", "pmid": "36017478", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9396233"}], "notes": [], "created": "2022-09-12T19:14:28.562Z", "modified": "2022-09-12T19:14:49.442Z"}, {"entity": "publication", "iuid": "22834b2fed9548b3bb79b639f1a3d7ab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/22834b2fed9548b3bb79b639f1a3d7ab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/22834b2fed9548b3bb79b639f1a3d7ab"}}, "title": "T cell perturbations persist for at least 6 months following hospitalization for COVID-19.", "authors": [{"family": "Govender", "given": "Melissa", "initials": "M"}, {"family": "Hopkins", "given": "Francis R", "initials": "FR"}, {"family": "G\u00f6ransson", "given": "Robin", "initials": "R"}, {"family": "Svanberg", "given": "Cecilia", "initials": "C"}, {"family": "Shankar", "given": "Esaki M", "initials": "EM"}, {"family": "Hjorth", "given": "Maria", "initials": "M"}, {"family": "Nilsdotter-Augustinsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Sj\u00f6wall", "given": "Johanna", "initials": "J"}, {"family": "Nystr\u00f6m", "given": "Sofia", "initials": "S"}, {"family": "Larsson", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2022-08-08", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "13", "pages": "931039", "issn-l": "1664-3224"}, "abstract": "COVID-19 is being extensively studied, and much remains unknown regarding the long-term consequences of the disease on immune cells. The different arms of the immune system are interlinked, with humoral responses and the production of high-affinity antibodies being largely dependent on T cell immunity. Here, we longitudinally explored the effect COVID-19 has on T cell populations and the virus-specific T cells, as well as neutralizing antibody responses, for 6-7 months following hospitalization. The CD8+ TEMRA and exhausted CD57+ CD8+ T cells were markedly affected with elevated levels that lasted long into convalescence. Further, markers associated with T cell activation were upregulated at inclusion, and in the case of CD69+ CD4+ T cells this lasted all through the study duration. The levels of T cells expressing negative immune checkpoint molecules were increased in COVID-19 patients and sustained for a prolonged duration following recovery. Within 2-3 weeks after symptom onset, all COVID-19 patients developed anti-nucleocapsid IgG and spike-neutralizing IgG as well as SARS-CoV-2-specific T cell responses. In addition, we found alterations in follicular T helper (TFH) cell populations, such as enhanced TFH-TH2 following recovery from COVID-19. Our study revealed significant and long-term alterations in T cell populations and key events associated with COVID-19 pathogenesis.", "doi": "10.3389/fimmu.2022.931039", "pmid": "36003367", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9393525"}], "notes": [], "created": "2022-08-26T04:42:30.271Z", "modified": "2022-08-26T04:42:30.286Z"}, {"entity": "publication", "iuid": "c5087e20c8ef4b42b7b9db2e05de09bc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5087e20c8ef4b42b7b9db2e05de09bc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5087e20c8ef4b42b7b9db2e05de09bc"}}, "title": "Global statements to produce and implement evidence in the post-COVID-19 era provide a path forward for rehabilitation - A joint initiative of Cochrane Rehabilitation and the leading journals in the field.", "authors": [{"family": "Negrini", "given": "Stefano", "initials": "S"}, {"family": "Borg", "given": "Kristian", "initials": "K"}, {"family": "Cusick", "given": "Anne", "initials": "A"}, {"family": "Ferriero", "given": "Giorgio", "initials": "G"}, {"family": "Frontera", "given": "Walter R", "initials": "WR"}, {"family": "Gross", "given": "Douglas P", "initials": "DP"}, {"family": "Heinemann", "given": "Allen", "initials": "A"}, {"family": "Machalicek", "given": "Wendy", "initials": "W"}, {"family": "Moore", "given": "Ann Patricia", "initials": "AP"}, {"family": "Nudo", "given": "Randolph J", "initials": "RJ"}, {"family": "P\u00e9rennou", "given": "Dominic", "initials": "D"}, {"family": "Stam", "given": "Henk", "initials": "H"}, {"family": "Kiekens", "given": "Carlotte", "initials": "C"}], "type": "editorial", "published": "2022-08-08", "journal": {"title": "Ann Phys Rehabil Med", "issn": "1877-0665", "volume": "65", "issue": "5", "pages": "101688", "issn-l": null}, "abstract": null, "doi": "10.1016/j.rehab.2022.101688", "pmid": "35811074", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1877-0657(22)00060-4"}, {"db": "pmc", "key": "PMC9359696"}], "notes": [], "created": "2022-08-17T10:39:30.587Z", "modified": "2022-08-17T10:39:30.623Z"}, {"entity": "publication", "iuid": "0b5b126f50454bbc9c63c07953df7ef6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b5b126f50454bbc9c63c07953df7ef6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b5b126f50454bbc9c63c07953df7ef6"}}, "title": "DOCK2 is involved in the host genetics and biology of severe COVID-19.", "authors": [{"family": "Namkoong", "given": "Ho", "initials": "H"}, {"family": "Edahiro", "given": "Ryuya", "initials": "R"}, {"family": "Takano", "given": "Tomomi", "initials": "T", "orcid": "0000-0002-3468-0708", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adde787b5bc444f0a112ba88082598b6.json"}}, {"family": "Nishihara", "given": "Hiroshi", "initials": "H"}, {"family": "Shirai", "given": "Yuya", "initials": "Y"}, {"family": "Sonehara", "given": "Kyuto", "initials": "K"}, {"family": "Tanaka", "given": "Hiromu", "initials": "H"}, {"family": "Azekawa", "given": "Shuhei", "initials": "S"}, {"family": "Mikami", "given": "Yohei", "initials": "Y", "orcid": "0000-0001-5104-4415", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/973a5f4549f34bd48380bb590c496dc1.json"}}, {"family": "Lee", "given": "Ho", "initials": "H"}, {"family": "Hasegawa", "given": "Takanori", "initials": "T"}, {"family": "Okudela", "given": "Koji", "initials": "K"}, {"family": "Okuzaki", "given": "Daisuke", "initials": "D", "orcid": "0000-0002-4552-783X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ccf9bee61674fe38e3acf6221678f35.json"}}, {"family": "Motooka", "given": "Daisuke", "initials": "D"}, {"family": "Kanai", "given": "Masahiro", "initials": "M", "orcid": "0000-0001-5165-4408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01d858a30cea453d91cedab1fd5c8494.json"}}, {"family": "Naito", "given": "Tatsuhiko", "initials": "T", "orcid": "0000-0002-2779-4600", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b0897a4c92b4ca781c81fc0d5520385.json"}}, {"family": "Yamamoto", "given": "Kenichi", "initials": "K", "orcid": "0000-0001-9594-7050", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d494d739ff8469c9f6def67c94cb3ef.json"}}, {"family": "Wang", "given": "Qingbo S", "initials": "QS"}, {"family": "Saiki", "given": "Ryunosuke", "initials": "R", "orcid": "0000-0001-6984-7187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd5bae576b614b1f9e27c3975f2f72a2.json"}}, {"family": "Ishihara", "given": "Rino", "initials": "R", "orcid": "0000-0002-1312-6732", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d8a7f8f668d4e7989545df4ce82f649.json"}}, {"family": "Matsubara", "given": "Yuta", "initials": "Y"}, {"family": "Hamamoto", "given": "Junko", "initials": "J"}, {"family": "Hayashi", "given": "Hiroyuki", "initials": "H"}, {"family": "Yoshimura", "given": "Yukihiro", "initials": "Y"}, {"family": "Tachikawa", "given": "Natsuo", "initials": "N"}, {"family": "Yanagita", "given": "Emmy", "initials": "E"}, {"family": "Hyugaji", "given": "Takayoshi", "initials": "T"}, {"family": "Shimizu", "given": "Eigo", "initials": "E"}, {"family": "Katayama", "given": "Kotoe", "initials": "K", "orcid": "0000-0002-3966-1231", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68f93c3d200e45cea3eaea3a1758f0af.json"}}, {"family": "Kato", "given": "Yasuhiro", "initials": "Y"}, {"family": "Morita", "given": "Takayoshi", "initials": "T"}, {"family": "Takahashi", "given": "Kazuhisa", "initials": "K"}, {"family": "Harada", "given": "Norihiro", "initials": "N"}, {"family": "Naito", "given": "Toshio", "initials": "T"}, {"family": "Hiki", "given": "Makoto", "initials": "M"}, {"family": "Matsushita", "given": "Yasushi", "initials": "Y"}, {"family": "Takagi", "given": "Haruhi", "initials": "H"}, {"family": "Aoki", "given": "Ryousuke", "initials": "R"}, {"family": "Nakamura", "given": "Ai", "initials": "A"}, {"family": "Harada", "given": "Sonoko", "initials": "S"}, {"family": "Sasano", "given": "Hitoshi", "initials": "H"}, {"family": "Kabata", "given": "Hiroki", "initials": "H"}, {"family": "Masaki", "given": "Katsunori", "initials": "K"}, {"family": "Kamata", "given": "Hirofumi", "initials": "H"}, {"family": "Ikemura", "given": "Shinnosuke", "initials": "S"}, {"family": "Chubachi", "given": "Shotaro", "initials": "S"}, {"family": "Okamori", "given": "Satoshi", "initials": "S"}, {"family": "Terai", "given": "Hideki", "initials": "H"}, {"family": "Morita", "given": "Atsuho", "initials": "A"}, {"family": "Asakura", "given": "Takanori", "initials": "T"}, {"family": "Sasaki", "given": "Junichi", "initials": "J"}, {"family": "Morisaki", "given": "Hiroshi", "initials": "H"}, {"family": "Uwamino", "given": "Yoshifumi", "initials": "Y"}, {"family": "Nanki", "given": "Kosaku", "initials": "K"}, {"family": "Uchida", "given": "Sho", "initials": "S"}, {"family": "Uno", "given": "Shunsuke", "initials": "S"}, {"family": "Nishimura", "given": "Tomoyasu", "initials": "T"}, {"family": "Ishiguro", "given": "Takashi", "initials": "T"}, {"family": "Isono", "given": "Taisuke", "initials": "T"}, {"family": "Shibata", "given": "Shun", "initials": "S"}, {"family": "Matsui", "given": "Yuma", "initials": "Y"}, {"family": "Hosoda", "given": "Chiaki", "initials": "C"}, {"family": "Takano", "given": "Kenji", "initials": "K"}, {"family": "Nishida", "given": "Takashi", "initials": "T"}, {"family": "Kobayashi", "given": "Yoichi", "initials": "Y"}, {"family": "Takaku", "given": "Yotaro", "initials": "Y"}, {"family": "Takayanagi", "given": "Noboru", "initials": "N"}, {"family": "Ueda", "given": "Soichiro", "initials": "S"}, {"family": "Tada", "given": "Ai", "initials": "A"}, {"family": "Miyawaki", "given": "Masayoshi", "initials": "M"}, {"family": "Yamamoto", "given": "Masaomi", "initials": "M"}, {"family": "Yoshida", "given": "Eriko", "initials": "E"}, {"family": "Hayashi", "given": "Reina", "initials": "R"}, {"family": "Nagasaka", "given": "Tomoki", "initials": "T"}, {"family": "Arai", "given": "Sawako", "initials": "S"}, {"family": "Kaneko", "given": "Yutaro", "initials": "Y"}, {"family": "Sasaki", "given": "Kana", "initials": "K"}, {"family": "Tagaya", "given": "Etsuko", "initials": "E"}, {"family": "Kawana", "given": "Masatoshi", "initials": "M"}, {"family": "Arimura", "given": "Ken", "initials": "K"}, {"family": "Takahashi", "given": "Kunihiko", "initials": "K"}, {"family": "Anzai", "given": "Tatsuhiko", "initials": "T"}, {"family": "Ito", "given": "Satoshi", "initials": "S"}, {"family": "Endo", "given": "Akifumi", "initials": "A"}, {"family": "Uchimura", "given": "Yuji", "initials": "Y"}, {"family": "Miyazaki", "given": "Yasunari", "initials": "Y"}, {"family": "Honda", "given": "Takayuki", "initials": "T"}, {"family": "Tateishi", "given": "Tomoya", "initials": "T"}, {"family": "Tohda", "given": "Shuji", "initials": "S"}, {"family": "Ichimura", "given": "Naoya", "initials": "N"}, {"family": "Sonobe", "given": "Kazunari", "initials": "K"}, {"family": "Sassa", "given": "Chihiro Tani", "initials": "CT"}, {"family": "Nakajima", "given": "Jun", "initials": "J"}, {"family": "Nakano", "given": "Yasushi", "initials": "Y"}, {"family": "Nakajima", "given": "Yukiko", "initials": "Y"}, {"family": "Anan", "given": "Ryusuke", "initials": "R"}, {"family": "Arai", "given": "Ryosuke", "initials": "R"}, {"family": "Kurihara", "given": "Yuko", "initials": "Y"}, {"family": "Harada", "given": "Yuko", "initials": "Y"}, {"family": "Nishio", "given": "Kazumi", "initials": "K"}, {"family": "Ueda", "given": "Tetsuya", "initials": "T"}, {"family": "Azuma", "given": "Masanori", "initials": "M"}, {"family": "Saito", "given": "Ryuichi", "initials": "R"}, {"family": "Sado", "given": "Toshikatsu", "initials": "T"}, {"family": "Miyazaki", "given": "Yoshimune", "initials": "Y"}, {"family": "Sato", "given": "Ryuichi", "initials": "R"}, {"family": "Haruta", "given": "Yuki", "initials": "Y"}, {"family": "Nagasaki", "given": "Tadao", "initials": "T"}, {"family": "Yasui", "given": "Yoshinori", "initials": "Y"}, {"family": "Hasegawa", "given": "Yoshinori", "initials": "Y"}, {"family": "Mutoh", "given": "Yoshikazu", "initials": "Y"}, {"family": "Kimura", "given": "Tomoki", "initials": "T"}, {"family": "Sato", "given": "Tomonori", "initials": "T"}, {"family": "Takei", "given": "Reoto", "initials": "R"}, {"family": "Hagimoto", "given": "Satoshi", "initials": "S"}, {"family": "Noguchi", "given": "Yoichiro", "initials": "Y"}, {"family": "Yamano", "given": "Yasuhiko", "initials": "Y"}, {"family": "Sasano", "given": "Hajime", "initials": "H"}, {"family": "Ota", "given": "Sho", "initials": "S"}, {"family": "Nakamori", "given": "Yasushi", "initials": "Y"}, {"family": "Yoshiya", "given": "Kazuhisa", "initials": "K"}, {"family": "Saito", "given": "Fukuki", "initials": "F"}, {"family": "Yoshihara", "given": "Tomoyuki", "initials": "T"}, {"family": "Wada", "given": "Daiki", "initials": "D"}, {"family": "Iwamura", "given": "Hiromu", "initials": "H"}, {"family": "Kanayama", "given": "Syuji", "initials": "S"}, {"family": "Maruyama", "given": "Shuhei", "initials": "S"}, {"family": "Yoshiyama", "given": "Takashi", "initials": "T"}, {"family": "Ohta", "given": "Ken", "initials": "K"}, {"family": "Kokuto", "given": "Hiroyuki", "initials": "H"}, {"family": "Ogata", "given": "Hideo", "initials": "H"}, {"family": "Tanaka", "given": "Yoshiaki", "initials": "Y"}, {"family": "Arakawa", "given": "Kenichi", "initials": "K"}, {"family": "Shimoda", "given": "Masafumi", "initials": "M"}, {"family": "Osawa", "given": "Takeshi", "initials": "T"}, {"family": "Tateno", "given": "Hiroki", "initials": "H"}, {"family": "Hase", "given": "Isano", "initials": "I"}, {"family": "Yoshida", "given": "Shuichi", "initials": "S"}, {"family": "Suzuki", "given": "Shoji", "initials": "S"}, {"family": "Kawada", "given": "Miki", "initials": "M"}, {"family": "Horinouchi", "given": "Hirohisa", "initials": "H"}, {"family": "Saito", "given": "Fumitake", "initials": "F"}, {"family": "Mitamura", "given": "Keiko", "initials": "K"}, {"family": "Hagihara", "given": "Masao", "initials": "M"}, {"family": "Ochi", "given": "Junichi", "initials": "J"}, {"family": "Uchida", "given": "Tomoyuki", "initials": "T"}, {"family": "Baba", "given": "Rie", "initials": "R"}, {"family": "Arai", "given": "Daisuke", "initials": "D"}, {"family": "Ogura", "given": "Takayuki", "initials": "T"}, {"family": "Takahashi", "given": "Hidenori", "initials": "H"}, {"family": "Hagiwara", "given": "Shigehiro", "initials": "S"}, {"family": "Nagao", "given": "Genta", "initials": "G"}, {"family": "Konishi", "given": "Shunichiro", "initials": "S"}, {"family": "Nakachi", "given": "Ichiro", "initials": "I"}, {"family": "Murakami", "given": "Koji", "initials": "K"}, {"family": "Yamada", "given": "Mitsuhiro", "initials": "M"}, {"family": "Sugiura", "given": "Hisatoshi", "initials": "H"}, {"family": "Sano", "given": "Hirohito", "initials": "H"}, {"family": "Matsumoto", "given": "Shuichiro", "initials": "S"}, {"family": "Kimura", "given": "Nozomu", "initials": "N"}, {"family": "Ono", "given": "Yoshinao", "initials": "Y"}, {"family": "Baba", "given": "Hiroaki", "initials": "H"}, {"family": "Suzuki", "given": "Yusuke", "initials": "Y"}, {"family": "Nakayama", "given": "Sohei", "initials": "S"}, {"family": "Masuzawa", "given": "Keita", "initials": "K"}, {"family": "Namba", "given": "Shinichi", "initials": "S"}, {"family": "Suzuki", "given": "Ken", "initials": "K"}, {"family": "Naito", "given": "Yoko", "initials": "Y"}, 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"initials": "T"}, {"family": "Amiya", "given": "Saori", "initials": "S"}, {"family": "Hara", "given": "Reina", "initials": "R"}, {"family": "Yamaguchi", "given": "Yuta", "initials": "Y"}, {"family": "Murakami", "given": "Teruaki", "initials": "T"}, {"family": "Kuge", "given": "Tomoki", "initials": "T"}, {"family": "Matsumoto", "given": "Kinnosuke", "initials": "K"}, {"family": "Yamamoto", "given": "Yuji", "initials": "Y"}, {"family": "Yamamoto", "given": "Makoto", "initials": "M"}, {"family": "Yoneda", "given": "Midori", "initials": "M"}, {"family": "Kishikawa", "given": "Toshihiro", "initials": "T"}, {"family": "Yamada", "given": "Shuhei", "initials": "S"}, {"family": "Kawabata", "given": "Shuhei", "initials": "S"}, {"family": "Kijima", "given": "Noriyuki", "initials": "N"}, {"family": "Takagaki", "given": "Masatoshi", "initials": "M"}, {"family": "Sasa", "given": "Noah", "initials": "N"}, {"family": "Ueno", "given": "Yuya", "initials": "Y"}, {"family": "Suzuki", "given": "Motoyuki", 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"Takeru", "initials": "T"}, {"family": "Fujita", "given": "Kazue", "initials": "K"}, {"family": "Saito", "given": "Yoshinobu", "initials": "Y"}, {"family": "Seike", "given": "Masahiro", "initials": "M"}, {"family": "Watanabe", "given": "Hiroko", "initials": "H"}, {"family": "Matsuse", "given": "Hiroto", "initials": "H"}, {"family": "Kodaka", "given": "Norio", "initials": "N"}, {"family": "Nakano", "given": "Chihiro", "initials": "C"}, {"family": "Oshio", "given": "Takeshi", "initials": "T"}, {"family": "Hirouchi", "given": "Takatomo", "initials": "T"}, {"family": "Makino", "given": "Shohei", "initials": "S"}, {"family": "Egi", "given": "Moritoki", "initials": "M"}, {"family": "Biobank Japan Project", "given": "", "initials": ""}, {"family": "Omae", "given": "Yosuke", "initials": "Y"}, {"family": "Nannya", "given": "Yasuhito", "initials": "Y"}, {"family": "Ueno", "given": "Takafumi", "initials": "T", "orcid": "0000-0001-9219-0726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3cc40b72010340a2bba13d406334a1b3.json"}}, {"family": "Katayama", "given": "Kazuhiko", "initials": "K", "orcid": "0000-0002-7692-1151", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2c4b23a809c41d3b080359ad4ee88cd.json"}}, {"family": "Ai", "given": "Masumi", "initials": "M"}, {"family": "Fukui", "given": "Yoshinori", "initials": "Y", "orcid": "0000-0003-2335-8745", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f25a95eb6fc49f9bf216d9c223d6a0d.json"}}, {"family": "Kumanogoh", "given": "Atsushi", "initials": "A", "orcid": "0000-0003-4749-7117", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4565dd205dee4d1fa6644195ece55c6d.json"}}, {"family": "Sato", "given": "Toshiro", "initials": "T", "orcid": "0000-0001-8353-8137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e7a398c59724357ba5a2148184e914a.json"}}, {"family": "Hasegawa", "given": "Naoki", "initials": "N", "orcid": "0000-0003-0717-7450", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8e747324a074632b13eccd27a77b1cc.json"}}, {"family": "Tokunaga", "given": "Katsushi", "initials": "K"}, {"family": "Ishii", "given": "Makoto", "initials": "M", "orcid": "0000-0003-4396-1664", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/baeffc7d32584e36a16ccd0d1d39aeaa.json"}}, {"family": "Koike", "given": "Ryuji", "initials": "R"}, {"family": "Kitagawa", "given": "Yuko", "initials": "Y"}, {"family": "Kimura", "given": "Akinori", "initials": "A"}, {"family": "Imoto", "given": "Seiya", "initials": "S"}, {"family": "Miyano", "given": "Satoru", "initials": "S"}, {"family": "Ogawa", "given": "Seishi", "initials": "S"}, {"family": "Kanai", "given": "Takanori", "initials": "T"}, {"family": "Fukunaga", "given": "Koichi", "initials": "K"}, {"family": "Okada", "given": "Yukinori", "initials": "Y", "orcid": "0000-0002-0311-8472", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/180d7682259f44da968366b41662b959.json"}}], "type": "journal article", "published": "2022-08-08", "journal": {"title": "Nature", "issn": "1476-4687", "issn-l": "0028-0836"}, "abstract": "Identifying the factors underlying severe COVID-19 in the host genetics is an emerging issue1-5. We conducted a genome-wide association study (GWAS) involving 2,393 Japanese COVID-19 cases collected in initial pandemic waves with 3,289 controls, which identified a variant on 5q35 (rs60200309-A) near DOCK2 associated with severe COVID-19 in younger (<65 ages) patients (nCase=440, odds ratio=2.01, P=1.2\u00d710-8). This risk allele was prevalent in East Asians but rare in Europeans, showing a value of non-European GWAS. RNA-seq of 473 bulk peripheral blood identified decreasing effect of the risk allele on DOCK2 expression in younger patients. DOCK2 expression was suppressed in severe forms of COVID-19. Single cell RNA-seq analysis (n=61) identified cell type-specific downregulation of DOCK2 and COVID-19-specific decreasing effects of the risk allele on DOCK2 in non-classical monocytes. Immunohistochemistry of lung specimens from severe COVID-19 pneumonia showed suppressed DOCK2. Moreover, inhibition of DOCK2 function using CPYPP induced much more severe pneumonia in a Syrian hamster model of SARS-CoV-2 infection characterized as weight loss, lung edema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 plays an important role in the host immune response to SARS-CoV-2 infection and development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target.", "doi": "10.1038/s41586-022-05163-5", "pmid": "35940203", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41586-022-05163-5"}], "notes": [], "created": "2022-08-11T11:52:59.253Z", "modified": "2022-08-11T11:52:59.772Z"}, {"entity": "publication", "iuid": "b024bbc25781496fa75cd6860d48563d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b024bbc25781496fa75cd6860d48563d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b024bbc25781496fa75cd6860d48563d"}}, "title": "Coronavirus pandemic in the Nordic countries: Health policy and economy trade-off.", "authors": [{"family": "Irfan", "given": "Furqan B", "initials": "FB"}, {"family": "Minetti", "given": "Raoul", "initials": "R"}, {"family": "Telford", "given": "Ben", "initials": "B"}, {"family": "Ahmed", "given": "Fahad S", "initials": "FS"}, {"family": "Syed", "given": "Ayesha Y", "initials": "AY"}, {"family": "Hollon", "given": "Nick", "initials": "N"}, {"family": "Brauman", "given": "Seth C", "initials": "SC"}, {"family": "Cunningham", "given": "William", "initials": "W"}, {"family": "Awad", "given": "Mohamed E", "initials": "ME"}, {"family": "Saleh", "given": "Khaled J", "initials": "KJ"}, {"family": "Waljee", "given": "Akbar K", "initials": "AK"}, {"family": "Brusselaers", "given": "Nele", "initials": "N"}], "type": "journal article", "published": "2022-08-08", "journal": {"title": "J Glob Health", "issn": "2047-2986", "volume": "12", "pages": "05017", "issn-l": "2047-2978"}, "abstract": "Countries making up the Nordic region - Denmark, Finland, Iceland, Norway, and Sweden - have minimal socioeconomic, cultural, and geographical differences between them, allowing for a fair comparative analysis of the health policy and economy trade-off in their national approaches towards mitigating the impact of the COVID-19 pandemic.\n\nThis study utilized publicly available COVID-19 data of the Nordic countries from January 2020 to January 3, 2021. COVID-19 epidemiology, public health and health policy, health system capacity, and macroeconomic data were analysed for each Nordic country. Joinpoint regression analysis was performed to identify changes in temporal trends using average monthly percent change (AMPC) and average weekly percent change (AWPC).\n\nSweden's health policy, being by far the most relaxed response to COVID-19, was found to have the largest COVID-19 incidence and mortality, and the highest AWPC increases for both indicators (13.5, 95% CI = 5.6, 22.0, P < 0.001; 6.3, 95% CI = 3.5, 9.1, P < 0.001). Denmark had the highest number of COVID-19 tests per capita, consistent with their approach of increased testing as a preventive strategy for disease transmission. Iceland had the second-highest number of tests per capita due to their mass-testing, contact tracing, quarantine and isolation response. Only Norway had a significant increase in unemployment (AMPC = 2.8%, 95% CI = 0.7-4.9, P < 0.009) while the percentage change in real Gross Domestic Product (GDP) was insignificant for all countries.\n\nThere was no trade-off between public health policy and economy during the COVID-19 pandemic in the Nordic region. Sweden's relaxed and delayed COVID-19 health policy response did not benefit the economy in the short term, while leading to disproportionate COVID-19 hospitalizations and mortality.", "doi": "10.7189/jogh.12.05017", "pmid": "35932219", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-08-11T11:56:37.963Z", "modified": "2022-08-11T11:56:37.976Z"}, {"entity": "publication", "iuid": "686e9094e2a844ee97d3d70c71eba151", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/686e9094e2a844ee97d3d70c71eba151.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/686e9094e2a844ee97d3d70c71eba151"}}, "title": "Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants.", "authors": [{"family": "Monteil", "given": "Vanessa", "initials": "V", "orcid": "0000-0002-2652-5695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8ba8a0b1af6423b9cba0fc4bb3177cd.json"}}, {"family": "Eaton", "given": "Brett", "initials": "B"}, {"family": "Postnikova", "given": "Elena", "initials": "E"}, {"family": "Murphy", "given": "Michael", "initials": "M"}, {"family": "Braunsfeld", "given": "Benedict", "initials": "B", "orcid": "0000-0002-0286-8239", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a74b9e08f1e46638f44e0756d9bc4af.json"}}, {"family": "Crozier", "given": "Ian", "initials": "I"}, {"family": "Kricek", "given": "Franz", "initials": "F"}, {"family": "Niederh\u00f6fer", "given": "Janine", "initials": "J"}, {"family": "Schwarzb\u00f6ck", "given": "Alice", "initials": "A"}, {"family": "Breid", "given": "Helene", "initials": "H"}, {"family": "Devignot", "given": "Stephanie", "initials": "S", "orcid": "0000-0002-0618-5611", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bacda93ff066472489568f9273ace099.json"}}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Kellner", "given": "Max J", "initials": "MJ"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Mereiter", "given": "Stefan", "initials": "S", "orcid": "0000-0002-4832-3090", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1974c14a7be4583a96ceecccbda4f19.json"}}, {"family": "Knapp", "given": "Sylvia", "initials": "S", "orcid": "0000-0001-9016-5244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81c1b98b50754c84b62f7867c9dc453f.json"}}, {"family": "Sanchez Jimenez", "given": "Anna", "initials": "A"}, {"family": "Bugajska-Schretter", "given": "Agnes", "initials": "A", "orcid": "0000-0002-2096-5833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6fcc0fa6cf5d4023834339edd6f743db.json"}}, {"family": "Dohnal", "given": "Alexander", "initials": "A", "orcid": "0000-0002-5844-7329", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9683bf8c8dc47c38bff0cbc9232cd4a.json"}}, {"family": "Ruf", "given": "Christine", "initials": "C"}, {"family": "Gugenberger", "given": "Romana", "initials": "R"}, {"family": "Hagelkruys", "given": "Astrid", "initials": "A", "orcid": "0000-0003-3015-4038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aab27066bf2a4cfbbe675bac0df00156.json"}}, {"family": "Montserrat", "given": "Nuria", "initials": "N", "orcid": "0000-0002-1603-1755", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d4cdae2b5b34dd798f73faa0a3aa391.json"}}, {"family": "Kozieradzki", "given": "Ivona", "initials": "I", "orcid": "0000-0001-8189-3346", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c581959ead34ffe814262e1f18b0216.json"}}, {"family": "Hasan Ali", "given": "Omar", "initials": "O", "orcid": "0000-0001-5185-7520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a12bd2b13624a19be85fd370663a239.json"}}, {"family": "Stadlmann", "given": "Johannes", "initials": "J", "orcid": "0000-0001-5693-6690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab12a13b3ddd442588c1c9bda683d9ee.json"}}, {"family": "Holbrook", "given": "Michael R", "initials": "MR", "orcid": "0000-0002-0824-2667", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fca43f2c8e934b438491b1dbf3fc0e7f.json"}}, {"family": "Schmaljohn", "given": "Connie", "initials": "C"}, {"family": "Oostenbrink", "given": "Chris", "initials": "C", "orcid": "0000-0002-4232-2556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37566a0341cf4fd38366e43218cffd23.json"}}, {"family": "Shoemaker", "given": "Robert H", "initials": "RH", "orcid": "0000-0003-3608-1714", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4892275e3a6b472f9ef6a537a55e3dd8.json"}}, {"family": "Mirazimi", "given": "Ali", "initials": "A", "orcid": "0000-0003-2371-6055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0651be47429c4e5880a13b839d04fe1d.json"}}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G", "orcid": "0000-0001-7035-7038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70afca1611904e419eca43bde2d681be.json"}}, {"family": "Penninger", "given": "Josef M", "initials": "JM", "orcid": "0000-0002-8194-3777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e56aaa008524272bf252df804e06991.json"}}], "type": "journal article", "published": "2022-08-08", "journal": {"title": "EMBO Mol Med", "issn": "1757-4684", "volume": "14", "issue": "8", "pages": "e15230", "issn-l": "1757-4676"}, "abstract": "The recent emergence of multiple SARS-CoV-2 variants has caused considerable concern due to both reduced vaccine efficacy and escape from neutralizing antibody therapeutics. It is, therefore, paramount to develop therapeutic strategies that inhibit all known and future SARS-CoV-2 variants. Here, we report that all SARS-CoV-2 variants analyzed, including variants of concern (VOC) Alpha, Beta, Gamma, Delta, and Omicron, exhibit enhanced binding affinity to clinical grade and phase 2 tested recombinant human soluble ACE2 (APN01). Importantly, soluble ACE2 neutralized infection of VeroE6 cells and human lung epithelial cells by all current VOC strains with markedly enhanced potency when compared to reference SARS-CoV-2 isolates. Effective inhibition of infections with SARS-CoV-2 variants was validated and confirmed in two independent laboratories. These data show that SARS-CoV-2 variants that have emerged around the world, including current VOC and several variants of interest, can be inhibited by soluble ACE2, providing proof of principle of a pan-SARS-CoV-2 therapeutic.", "doi": "10.15252/emmm.202115230", "pmid": "35781796", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9350269"}], "notes": [], "created": "2022-08-15T15:27:01.239Z", "modified": "2022-08-15T15:27:40.940Z"}, {"entity": "publication", "iuid": "a3f700fba1f14d279a1fdcfd5903beac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3f700fba1f14d279a1fdcfd5903beac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3f700fba1f14d279a1fdcfd5903beac"}}, "title": "\"Will it Work as Well on Zoom?\" A Natural Experiment During the Covid-19 Pandemic of Delivering Parenting Groups Via Video Conferencing or in Person.", "authors": [{"family": "van Leuven", "given": "Livia", "initials": "L", "orcid": "0000-0002-2048-8600", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c90a8aae3d841b4808ef39e4db41214.json"}}, {"family": "Lalouni", "given": "Maria", "initials": "M"}, {"family": "Forster", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2022-08-08", "journal": {"title": "J Child Fam Stud", "issn": "1062-1024", "pages": "1-14", "issn-l": null}, "abstract": "While rates of child maltreatment increased during the Covid-19-pandemic, face-to-face interventions to support families got difficult to carry out due to restrictions. Meanwhile, many services do not have access to parenting programs designed for digital or remote delivery. A solution employed by some services was to use video conferencing (VC) to deliver their regular parenting programs. This study examined the effectiveness of the universal group-based parenting program ABC offered through VC instead of on-site meetings during the pandemic. Pre and post measurements were collected from 469 parents participating in either 1) ABC with VC meetings only, 2) on-site meetings only, or 3) blended - a combination of VC and on-site sessions. In addition, 74 group leaders completed a survey about their experiences of VC groups. Analyses showed general improvements in parent practices and child conduct over time, but no differences in effectiveness depending on the format of the parent group (VC, blended, or on-site). Qualitative analyses of group leaders' experiences revealed four key-themes pertaining to both challenges (e.g., concerns about parents' ability to benefit and learn parenting skills) and benefits (e.g., reaching parents who would not have been able to attend physical meetings) of VC groups. Overall, this study showed no significant differences in outcomes between the VC, blended, or on-site format of delivery. There are however limitations of this trial, and results should be considered preliminary. Effectiveness and potential negative consequences of replacing interventions intended to be delivered on-site with VC alternatives need to be further investigated in future trials.", "doi": "10.1007/s10826-022-02398-8", "pmid": "35965634", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "2398"}, {"db": "pmc", "key": "PMC9358366"}], "notes": [], "created": "2022-08-16T15:37:45.172Z", "modified": "2022-08-16T15:37:45.248Z"}, {"entity": "publication", "iuid": "49796efbb57e4d2390a404af3b639dec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49796efbb57e4d2390a404af3b639dec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49796efbb57e4d2390a404af3b639dec"}}, "title": "Subjective well-being among psychotherapists during the coronavirus disease pandemic: A cross-cultural survey from 12 european countries.", "authors": [{"family": "Van Hoy", "given": "Angelika", "initials": "A"}, {"family": "Rzeszutek", "given": "Marcin", "initials": "M"}, {"family": "Pi\u0119ta", "given": "Ma\u0142gorzata", "initials": "M"}, {"family": "Mestre", "given": "Jose M", "initials": "JM"}, {"family": "Rodr\u00edguez-Mora", "given": "\u00c1lvaro", "initials": "\u00c1"}, {"family": "Midgley", "given": "Nick", "initials": "N"}, {"family": "Omylinska-Thurston", "given": "Joanna", "initials": "J"}, {"family": "Dopierala", "given": "Anna", "initials": "A"}, {"family": "Falkenstr\u00f6m", "given": "Fredrik", "initials": "F"}, {"family": "Ferlin", "given": "Jennie", "initials": "J"}, {"family": "Gergov", "given": "Vera", "initials": "V"}, {"family": "Lazi\u0107", "given": "Milica", "initials": "M"}, {"family": "Ulberg", "given": "Randi", "initials": "R"}, {"family": "R\u00f8ssberg", "given": "Jan Ivar", "initials": "JI"}, {"family": "Hancheva", "given": "Camellia", "initials": "C"}, {"family": "Stoyanova", "given": "Stanislava", "initials": "S"}, {"family": "Schmidt", "given": "Stefanie J", "initials": "SJ"}, {"family": "Podina", "given": "Ioana R", "initials": "IR"}, {"family": "Ferreira", "given": "Nuno", "initials": "N"}, {"family": "Kagialis", "given": "Antonios", "initials": "A"}, {"family": "L\u00f6ffler-Stastka", "given": "Henriette", "initials": "H"}, {"family": "Gruszczy\u0144ska", "given": "Ewa", "initials": "E"}], "type": "journal article", "published": "2022-08-07", "journal": {"title": "J Psychiatr Res", "issn": "1879-1379", "volume": "154", "pages": "315-323", "issn-l": null}, "abstract": "The aim of this study is to examine the amount of the total variance of the subjective well-being (SWB) of psychotherapists from 12 European countries explained by between-country vs. between-person differences regarding its cognitive (life satisfaction) and affective components (positive affect [PA] and negative affect [NA]). Second, we explored a link between the SWB and their personal (self-efficacy) and social resources (social support) after controlling for sociodemographics, work characteristics, and COVID-19-related distress.\n\nIn total, 2915 psychotherapists from 12 countries (Austria, Bulgaria, Cyprus, Finland, Great Britain, Serbia, Spain, Norway, Poland, Romania, Sweden, and Switzerland) participated in this study. The participants completed the Satisfaction with Life Scale (SWLS), the International Positive and Negative Affect Schedule Short Form (I-PANAS-SF), the General Self-Efficacy Scale, and the Multidimensional Scale of Perceived Social Support.\n\nCognitive well-being (CWB; satisfaction with life) was a more country-dependent component of SWB than affective well-being (AWB). Consequently, at the individual level, significant correlates were found only for AWB but not for CWB. Higher AWB was linked to being female, older age, higher weekly workload, and lower COVID-19-related distress. Self-efficacy and social support explained AWB only, including their main effects and the moderating effect of self-efficacy.\n\nThe results highlight more individual characteristics of AWB compared to CWB, with a more critical role of low self-efficacy for the link between social support and PA rather than NA. This finding suggests the need for greater self-care among psychotherapists regarding their AWB and the more complex conditions underlying their CWB.", "doi": "10.1016/j.jpsychires.2022.07.065", "pmid": "35994913", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0022-3956(22)00443-5"}, {"db": "pmc", "key": "PMC9357039"}], "notes": [], "created": "2022-09-12T19:01:18.681Z", "modified": "2022-09-12T19:01:29.291Z"}, {"entity": "publication", "iuid": "7b4e92ff01204931bc15070565b2691c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b4e92ff01204931bc15070565b2691c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b4e92ff01204931bc15070565b2691c"}}, "title": "Effectiveness of the BNT162b2 mRNA Vaccine Compared with Hybrid Immunity in Populations Prioritized and Non-Prioritized for COVID-19 Vaccination in 2021-2022: A Naturalistic Case-Control Study in Sweden.", "authors": [{"family": "Spreco", "given": "Armin", "initials": "A", "orcid": "0000-0003-0985-8209", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29a7cab23d784f898e1706bb138caa0f.json"}}, {"family": "Dahlstr\u00f6m", "given": "\u00d6rjan", "initials": "\u00d6", "orcid": "0000-0002-3955-0443", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21ead9243d644fe3a280e7b22d974745.json"}}, {"family": "J\u00f6ud", "given": "Anna", "initials": "A", "orcid": "0000-0001-7192-4911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e038a5ce2f5a47bd89e7c221651a3d24.json"}}, {"family": "Nordvall", "given": "Dennis", "initials": "D"}, {"family": "Fagerstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Blomqvist", "given": "Eva", "initials": "E", "orcid": "0000-0003-0036-6662", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/246bd5fbd6e7428b82a39e69e5ad7491.json"}}, {"family": "Gustafsson", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-3270-171X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a43a8fb037c340d5bd85b81fcabc69d5.json"}}, {"family": "Hinkula", "given": "Jorma", "initials": "J", "orcid": "0000-0003-1908-5609", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c5c582ce23e4e608680e31197be2fc7.json"}}, {"family": "Sch\u00f6n", "given": "Thomas", "initials": "T"}, {"family": "Timpka", "given": "Toomas", "initials": "T", "orcid": "0000-0001-6049-5402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebcb4fac20f845a4bd9eaa4bf1660ebb.json"}}], "type": "journal article", "published": "2022-08-07", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "8", "pages": "1273", "issn-l": null}, "abstract": "The term hybrid immunity is used to denote the immunological status of vaccinated individuals with a history of natural infection. Reports of new SARS-CoV-2 variants of concern motivate continuous rethought and renewal of COVID-19 vaccination programs. We used a naturalistic case-control study design to compare the effectiveness of the BNT162b2 mRNA vaccine to hybrid immunity 180 days post-vaccination in prioritized and non-prioritized populations vaccinated before 31 July 2021 in three Swedish counties (total population 1,760,000). Subjects with a positive SARS-CoV-2 test recorded within 6 months before vaccination (n = 36,247; 6%) were matched to vaccinated-only controls. In the prioritized population exposed to the SARS-CoV-2 Alpha and Delta variants post-vaccination, the odds ratio (OR) for breakthrough infection was 2.2 (95% CI, 1.6\u22122.8; p < 0.001) in the vaccinated-only group compared with the hybrid immunity group, while in the later vaccinated non-prioritized population, the OR decreased from 4.3 (95% CI, 2.2\u22128.6; p < 0.001) during circulation of the Delta variant to 1.9 (95% CI, 1.7\u22122.1; p < 0.001) with the introduction of the Omicron variant (B.1.617.2). We conclude that hybrid immunity provides gains in protection, but that the benefits are smaller for risk groups and with circulation of the Omicron variant and its sublineages.", "doi": "10.3390/vaccines10081273", "pmid": "36016162", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9414381"}, {"db": "pii", "key": "vaccines10081273"}], "notes": [], "created": "2022-09-12T19:12:01.791Z", "modified": "2023-06-19T14:58:56.409Z"}, {"entity": "publication", "iuid": "13e363574aaa4eb0944287a36d5f46e9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13e363574aaa4eb0944287a36d5f46e9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13e363574aaa4eb0944287a36d5f46e9"}}, "title": "Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection.", "authors": [{"family": "Barturen", "given": "Guillermo", "initials": "G", "orcid": "0000-0003-2103-1028", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a338918e305480497c4e51b5874dd52.json"}}, {"family": "Carnero-Montoro", "given": "Elena", "initials": "E"}, {"family": "Mart\u00ednez-Bueno", "given": "Manuel", "initials": "M"}, {"family": "Rojo-Rello", "given": "Silvia", "initials": "S"}, {"family": "Sobrino", "given": "Beatriz", "initials": "B"}, {"family": "Porras-Perales", "given": "\u00d3scar", "initials": "\u00d3", "orcid": "0000-0001-7164-6616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8668d9ae7124937bad9b03d231447f3.json"}}, {"family": "Alc\u00e1ntara-Dom\u00ednguez", "given": "Clara", "initials": "C", "orcid": "0000-0002-4925-4955", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7cbf4f6c8e3f4bfea012bc2bcaf46a54.json"}}, {"family": "Bernardo", "given": "David", "initials": "D"}, {"family": "Alarc\u00f3n-Riquelme", "given": "Marta E", "initials": "ME", "orcid": "0000-0002-7632-4154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f74dd701d8442c992fe172be2d2c5bf.json"}}], "type": "journal article", "published": "2022-08-06", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "13", "issue": "1", "pages": "4597"}, "abstract": "SARS-CoV-2 infection can cause an inflammatory syndrome (COVID-19) leading, in many cases, to bilateral pneumonia, severe dyspnea, and in ~5% of these, death. DNA methylation is known to play an important role in the regulation of the immune processes behind COVID-19 progression, however it has not been studied in depth. In this study, we aim to evaluate the implication of DNA methylation in COVID-19 progression by means of a genome-wide DNA methylation analysis combined with DNA genotyping. The results reveal the existence of epigenomic regulation of functional pathways associated with COVID-19 progression and mediated by genetic loci. We find an environmental trait-related signature that discriminates mild from severe cases and regulates, among other cytokines, IL-6 expression via the transcription factor CEBP. The analyses suggest that an interaction between environmental contribution, genetics, and epigenetics might be playing a role in triggering the cytokine storm described in the most severe cases.", "doi": "10.1038/s41467-022-32357-2", "pmid": "35933486", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-022-32357-2"}, {"db": "pmc", "key": "PMC9357033"}], "notes": [], "created": "2022-08-11T11:55:38.059Z", "modified": "2022-11-18T09:52:20.620Z"}, {"entity": "publication", "iuid": "d9711d4c6520454ca075454488bedb44", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d9711d4c6520454ca075454488bedb44.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d9711d4c6520454ca075454488bedb44"}}, "title": "The Perception of the Patient Safety Climate by Health Professionals during the COVID-19 Pandemic-International Research.", "authors": [{"family": "Kosydar-Bochenek", "given": "Justyna", "initials": "J", "orcid": "0000-0003-1028-2286", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6d99072901c46bb9eadd702b89537e7.json"}}, {"family": "Krupa", "given": "Sabina", "initials": "S", "orcid": "0000-0002-3002-3153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/479d63dc95544c2ba3439438fc553192.json"}}, {"family": "Religa", "given": "Dorota", "initials": "D"}, {"family": "Friganovi\u0107", "given": "Adriano", "initials": "A", "orcid": "0000-0002-9528-6464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f01bf1aaf114c6fa7822f3dcb1d4dac.json"}}, {"family": "Oomen", "given": "Ber", "initials": "B"}, {"family": "Brioni", "given": "Elena", "initials": "E"}, {"family": "Iordanou", "given": "Stelios", "initials": "S", "orcid": "0000-0001-7618-0915", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc269f1e185e4d69a880ec7f875ff983.json"}}, {"family": "Suchoparski", "given": "Marcin", "initials": "M"}, {"family": "Knap", "given": "Ma\u0142gorzata", "initials": "M", "orcid": "0000-0003-0425-7631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d232bb7ac80463e9b4199b6a841f05a.json"}}, {"family": "M\u0119drzycka-D\u0105browska", "given": "Wioletta", "initials": "W", "orcid": "0000-0001-8377-4893", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ff04cc1fa0b4a7ba15bcdbdb287fda2.json"}}], "type": "journal article", "published": "2022-08-06", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "15", "issn-l": null}, "abstract": "The patient safety climate is a key element of quality in healthcare. It should be a priority in the healthcare systems of all countries in the world. The goal of patient safety programs is to prevent errors and reduce the potential harm to patients when using healthcare services. A safety climate is also necessary to ensure a safe working environment for healthcare professionals. The attitudes of healthcare workers toward patient safety in various aspects of work, organization and functioning of the ward are important elements of the organization's safety culture. The aim of this study was to determine the perception of the patient safety climate by healthcare workers during the COVID-19 pandemic.\n\nThe study was conducted in five European countries. The Safety Attitude Questionnaire (SAQ) short version was used for the study. A total of 1061 healthcare workers: physicians, nurses and paramedics, participated in this study.\n\nAll groups received the highest mean results on the stress recognition subscale (SR): nurses 98.77, paramedics 96.39 and physician 98.28. Nurses and physicians evaluated work conditions (WC) to be the lowest (47.19 and 44.99), while paramedics evaluated perceptions of management (PM) as the worst (46.44). Paramedics achieved statistically significantly lower scores compared to nurses and physicians in job satisfaction (JS), stress recognition (SR) and perception of management (PM) (p &lt; 0.0001). Paramedics compared to nurses and physicians rank better in working conditions (WC) in relation to patient safety (16.21%). Most often, persons of lower seniority scored higher in all subscales (p = 0.001). In Poland, Spain, France, Turkey, and Greece, healthcare workers scored highest in stress recognition (SR). In Poland, Spain, France, and Turkey, they assessed working conditions (WC) as the worst, while in Greece, the perception of management (PM) had the lowest result.\n\nParticipant perceptions about the patient safety climate were not at a particularly satisfactory level, and there is still a need for the development of patient safety culture in healthcare in Europe. Overall, positive working conditions, good management and effective teamwork can contribute to improving employees' attitudes toward patient safety. This study was carried out during the COVID-19 pandemic and should be repeated after its completion, and comparative studies will allow for a more precise determination of the safety climate in the assessment of employees.", "doi": "10.3390/ijerph19159712", "pmid": "35955067", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19159712"}, {"db": "pmc", "key": "PMC9368342"}], "notes": [], "created": "2022-08-16T15:42:44.739Z", "modified": "2022-08-16T15:42:44.963Z"}, {"entity": "publication", "iuid": "3bd9fe0e284e490b8a2809518c07b50f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3bd9fe0e284e490b8a2809518c07b50f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3bd9fe0e284e490b8a2809518c07b50f"}}, "title": "Binge-Watching and Mental Health Problems: A Systematic Review and Meta-Analysis.", "authors": [{"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Jafari", "given": "Elahe", "initials": "E", "orcid": "0000-0003-2553-8192", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2aee5b18f3b1425c85985e630c206bea.json"}}, {"family": "Potenza", "given": "Marc N", "initials": "MN", "orcid": "0000-0002-6323-1354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b6ecc2df9444fe0bd86487afa9bb58b.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Wu", "given": "Chien-Yi", "initials": "CY", "orcid": "0000-0003-0585-0293", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d56dd8eb9a114f8eb641ae5ca4764e08.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2022-08-06", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "15", "issn-l": null}, "abstract": "Binge-watching, the viewing of online videos or streamed content, may be associated with different types of mental health problems. The present study aimed to investigate the associations between binge-watching and five mental health concerns including depression, loneliness, sleep problems, anxiety, and stress.\n\nAcademic databases of PubMed, Scopus, Web of Science, ProQuest, PsycINFO, and Psych Articles were systematically searched through February of 2022. The Newcastle-Ottawa Scale was used to assess the methodological quality. A meta-analysis was performed on Fisher's z values as effect sizes, using a random effect model. Publication bias, small study effect, and moderators in this association were assessed.\n\nBinge-watching was significantly associated with the five types of mental health concerns with the most robust correlations found with stress (0.32) and anxiety (0.25). Stronger associations between binge-watching and two types of mental health problems (depression and sleep problems) were found during the COVID-19 pandemic than before the pandemic. Moreover, stronger associations between binge-watching and two types of mental health problems (stress and sleep problems) were found in developing countries than in developed countries.\n\nThe associations between binge-watching and mental health concerns were significant and positive. Programs and interventions to reduce binge-watching should be considered and tested.", "doi": "10.3390/ijerph19159707", "pmid": "35955069", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijerph19159707"}, {"db": "pmc", "key": "PMC9368441"}], "notes": [], "created": "2022-08-16T15:42:24.334Z", "modified": "2022-08-16T15:42:24.494Z"}, {"entity": "publication", "iuid": "e899b38a906b49f8a2b14ddd344b04a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e899b38a906b49f8a2b14ddd344b04a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e899b38a906b49f8a2b14ddd344b04a0"}}, "title": "A pilot clinical and radiographic study on the association between periodontitis and serious COVID-19 infection.", "authors": [{"family": "Gardelis", "given": "Panagiotis", "initials": "P"}, {"family": "Zekeridou", "given": "Alkisti", "initials": "A", "orcid": "0000-0001-9468-8958", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe50bb3ddfba4f0a89c53f18025abce1.json"}}, {"family": "Suh", "given": "Noemie", "initials": "N"}, {"family": "Le Terrier", "given": "Christophe", "initials": "C"}, {"family": "Stavropoulos", "given": "Andreas", "initials": "A", "orcid": "0000-0001-8161-3754", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c54209640baf41f4bc60dcec6174e241.json"}}, {"family": "Giannopoulou", "given": "Catherine", "initials": "C"}], "type": "journal article", "published": "2022-08-06", "journal": {"title": "Clin Exp Dent Res", "issn": "2057-4347", "issn-l": null}, "abstract": "During the pandemic of COVID-19, the scientific community tried to identify the risk factors that aggravate the viral infection. Oral health and specifically periodontitis have been shown to have a significant impact on overall health. Current, yet limited, evidence suggests a link between periodontal status and severity of COVID-19 infection.\n\nThe present pilot study aimed to assess whether younger patients (\u226460 years) that have been hospitalized in the intensive care unit (ICU) for severe COVID-19 infection were susceptible to severe periodontitis.\n\nAll dentate patients \u226460 years of age diagnosed with COVID-19 and surviving hospitalization in the ICU were considered for inclusion. Susceptibility to periodontitis was determined by assessing radiographic bone loss (RBL) in recent dental radiographs (posterior bitewings, periapical, and panoramic X-rays). RBL in % was obtained from the most affected tooth and patients were classified into: Stage I, RBL \u2264 15%; Stage II, RBL = 15%-33% and Stage III/IV, RBL \u2265 33%. The grade was defined using the RBL to age ratio on the most severely affected tooth. Patients were attributed to: Grade A, ratio <0.25; Grade B, ratio 0.25-1 and Grade C, ratio >1. Patients classified into Stage III/IV and Grade C were considered highly susceptible to periodontitis.\n\nOf 87 eligible patients, 30 patients were finally assessed radiographically and/or clinically; from the remaining 57 patients, 16 refused participation for various reasons and 41 could not be reached. Based on the radiographic assessment, all patients were periodontally compromised. Half of them were classified with Stage III/IV and Grade B or C; 26.7% were classified with Stage III/IV and Grade C.\n\nThe present pilot study showed that about half of the patients suffering from severe forms of COVID-19 infection in need of ICU admission suffered also from severe periodontitis, and about one-fourth of them were highly susceptible to it.", "doi": "10.1002/cre2.610", "pmid": "35932180", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-11T11:56:56.240Z", "modified": "2022-08-11T11:56:56.345Z"}, {"entity": "publication", "iuid": "aee729d636e1464e89c86ae436a9c572", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aee729d636e1464e89c86ae436a9c572.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aee729d636e1464e89c86ae436a9c572"}}, "title": "Vaccination nudges: A study of pre-booked COVID-19 vaccinations in Sweden.", "authors": [{"family": "Bonander", "given": "Carl", "initials": "C"}, {"family": "Ekman", "given": "Mats", "initials": "M"}, {"family": "Jakobsson", "given": "Niklas", "initials": "N"}], "type": "journal article", "published": "2022-08-05", "journal": {"title": "Soc Sci Med", "issn": "1873-5347", "volume": "309", "pages": "115248", "issn-l": null}, "abstract": "A nudge changes people's actions without removing their options or altering their incentives. During the COVID-19 vaccine rollout, the Swedish Region of Uppsala sent letters with pre-booked appointments to inhabitants aged 16-17 instead of opening up manual appointment booking. Using regional and municipal vaccination data, we document a higher vaccine uptake among 16- to 17-year-olds in Uppsala compared to untreated control regions (constructed using the synthetic control method as well as neighboring municipalities). The results highlight pre-booked appointments as a strategy for increasing vaccination rates in populations with low perceived risk.", "doi": "10.1016/j.socscimed.2022.115248", "pmid": "35969977", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0277-9536(22)00554-8"}, {"db": "pmc", "key": "PMC9354447"}], "notes": [], "created": "2022-08-16T15:37:03.576Z", "modified": "2022-08-19T05:26:49.553Z"}, {"entity": "publication", "iuid": "9a3667b343c94f65adf60d2de6216896", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9a3667b343c94f65adf60d2de6216896.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9a3667b343c94f65adf60d2de6216896"}}, "title": "Risk factors for anxiety and depression among pregnant women during COVID-19 pandemic - results of a web-based multinational cross-sectional study.", "authors": [{"family": "Kajdy", "given": "Anna", "initials": "A"}, {"family": "Sys", "given": "Dorota", "initials": "D"}, {"family": "Pokropek", "given": "Artur", "initials": "A"}, {"family": "Shaw", "given": "Steven W", "initials": "SW"}, {"family": "Chang", "given": "Tung-Yao", "initials": "TY"}, {"family": "Calda", "given": "Pavel", "initials": "P"}, {"family": "Acharya", "given": "Ganesh", "initials": "G"}, {"family": "Ben-Zion", "given": "Maya", "initials": "M"}, {"family": "Biron-Shental", "given": "Tal", "initials": "T"}, {"family": "Borowski", "given": "Dariusz", "initials": "D"}, {"family": "Czuba", "given": "Bartosz", "initials": "B"}, {"family": "Etchegaray", "given": "Adolfo", "initials": "A"}, {"family": "Feduniw", "given": "Stepan", "initials": "S"}, {"family": "Garcia-Mandujano", "given": "Rosario", "initials": "R"}, {"family": "Garcia Santacruz", "given": "Monica", "initials": "M"}, {"family": "Gil", "given": "Maria M", "initials": "MM"}, {"family": "Hassan", "given": "Sonia", "initials": "S"}, {"family": "Kwiatkowski", "given": "Sebastian", "initials": "S"}, {"family": "Martin-Arias", "given": "Arancha", "initials": "A"}, {"family": "Martinez-Portilla", "given": "Raigam Jafet", "initials": "RJ"}, {"family": "Prefumo", "given": "Federico", "initials": "F"}, {"family": "Rabijewski", "given": "Micha\u0142", "initials": "M"}, {"family": "Salomon", "given": "Laurent J", "initials": "LJ"}, {"family": "Tiller", "given": "Heidi", "initials": "H"}, {"family": "Verlohren", "given": "Stefan", "initials": "S"}, {"family": "Voon", "given": "Hian Yan", "initials": "HY"}, {"family": "Fernando Yanque-Robles", "given": "Omar", "initials": "O"}, {"family": "Yong", "given": "Soon Leong", "initials": "SL"}, {"family": "Poon", "given": "Liona C", "initials": "LC"}, {"family": "Mind-COVID Collaborative Team", "given": "", "initials": ""}], "type": "journal article", "published": "2022-08-05", "journal": {"title": "Int J Gynaecol Obstet", "issn": "1879-3479", "issn-l": null}, "abstract": "Mind-COVID is a prospective cross-sectional study aimed to assess risk factors for anxiety and depression among pregnant women during the COVID-19 pandemic. This study compares outcomes in middle-income economies and high-income economies.\n\n7,102 pregnant women from 12 high-income economies and 9 middle-income economies were included. The web-based survey used two standardised instruments, GAD-7 and PHQ-9.\n\nPregnant women in high-income economies reported higher PHQ-9 (0.18 SD, p<<0.001) and GAD-7 (0.08 SD, p=0.005) scores than those living in middle-income economies. Multivariate regression analysis showed that increasing PHQ-9 and GAD-7 scales were associated with mental health problems during pregnancy and the need of psychiatric treatment before pregnancy. PHQ-9 was associated with feeling of burden related to restrictions in social distancing and access to leisure activities. GAD-7 scores were associated with a pregnancy-related complication, fear of adverse outcomes in children related to COVID-19 and feeling of burden related to finances.\n\nAccording to this study, the imposed public health measures and hospital restrictions have left pregnant women more vulnerable during these difficult times. Adequate partner and family support during pregnancy and childbirth can be one of the most important protective factors against anxiety and depression, regardless of national economic status.", "doi": "10.1002/ijgo.14388", "pmid": "35932096", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-11T11:57:19.817Z", "modified": "2022-08-11T11:57:19.852Z"}, {"entity": "publication", "iuid": "3a7132762a8a493a89cfdd6c056d3dce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a7132762a8a493a89cfdd6c056d3dce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a7132762a8a493a89cfdd6c056d3dce"}}, "title": "Challenges imposed by the COVID-19 pandemic on the Obstetrics and Gynecology residency program: a mixed-methods Swedish survey in the COPE Staff cohort study.", "authors": [{"family": "W\u00e5dell", "given": "Matilda", "initials": "M"}, {"family": "\u00d6rtqvist", "given": "Anne K", "initials": "AK"}, {"family": "Linden", "given": "Karolina", "initials": "K"}, {"family": "Akerstrom", "given": "Magnus", "initials": "M"}, {"family": "Andersson", "given": "Ola", "initials": "O"}, {"family": "Carlsson", "given": "Ylva", "initials": "Y"}, {"family": "Graner", "given": "Sofie", "initials": "S"}, {"family": "Jonsson", "given": "Maria", "initials": "M"}, {"family": "Naurin", "given": "Elin", "initials": "E"}, {"family": "Sengpiel", "given": "Verena", "initials": "V"}, {"family": "Veje", "given": "Malin", "initials": "M"}, {"family": "Wessberg", "given": "Anna", "initials": "A"}, {"family": "Zaigham", "given": "Mehreen", "initials": "M"}], "type": "journal article", "published": "2022-08-05", "journal": {"title": "BMC Med Educ", "issn": "1472-6920", "volume": "22", "issue": "1", "pages": "602", "issn-l": null}, "abstract": "To outline how the training program and work situation of residents in Obstetrics and Gynecology (OB-GYN) was affected by the pandemic and to illuminate how residents experienced these changes.\n\nAs part of the COVID-19 in Pregnancy and Early Childhood Staff (COPE Staff) cohort study, between January and May 2021, all participating residents were invited to answer a 28-question online Resident Survey focusing on their specialist education, work situation and experiences during the COVID-19 pandemic. Descriptive statistics were given in percentages for categorical variables and means and standard deviations (SD) for continuous variables. Univariate comparative analyses were performed with the use of the Pearson's Chi-2-test for dichotomous data. The association between residents' worry about the quality and length of their specialist training, with extra clinical hours and transfer to other healthcare institutions were assessed by multivariate logistic regression. Free text responses were analyzed by content analysis.\n\nOf the 162 participating OB-GYN residents, 69% expressed concern that the pandemic would have a negative impact on their training. Ninety-five (95%) reported cancellation/postponement of educational activities, 70% performed fewer surgeries and 27% had been transferred to other healthcare institutions where about half reported having gained more general knowledge as a physician. Working extra clinical hours was reported by 69% (7.4 \u00b1 5.3 hours per week) and 14% had considered changing their profession due to the pandemic. Senior residents, compared to junior residents, more often experienced cancelled/postponed clinical rotations (30% vs 15%, P=0.02) and reported performing fewer surgeries (P=0.02). The qualitative analysis highlighted the lack of surgical procedural training as a major concern for residents.\n\nThe COVID-19 pandemic has strongly impacted the training program and work situation of OB-GYN residents in Sweden. Residents were concerned over the negative impact of the pandemic on their training program and senior residents reported more missed educational opportunities as compared to junior residents. Program directors, head of institutions and clinical supervisors can use the problem areas pinpointed by this study to support residents and compensate for missed educational opportunities. While hands-on-training and operating time cannot be compensated for, the authors hope that the findings of the study can help develop new strategies to minimize the negative impact of the current and future pandemics on resident education and work situation.", "doi": "10.1186/s12909-022-03631-0", "pmid": "35927725", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12909-022-03631-0"}, {"db": "pmc", "key": "PMC9354310"}], "notes": [], "created": "2022-08-11T12:00:24.793Z", "modified": "2022-08-11T12:00:24.806Z"}, {"entity": "publication", "iuid": "76979789107a4e098eaecbc23e9e6f00", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76979789107a4e098eaecbc23e9e6f00.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76979789107a4e098eaecbc23e9e6f00"}}, "title": "COVID-19 vaccination in pregnant women in Sweden and Norway.", "authors": [{"family": "\u00d6rtqvist", "given": "Anne K", "initials": "AK"}, {"family": "Dahlqwist", "given": "Elisabeth", "initials": "E"}, {"family": "Magnus", "given": "Maria C", "initials": "MC"}, {"family": "Ljung", "given": "Rickard", "initials": "R"}, {"family": "Jonsson", "given": "Jerker", "initials": "J"}, {"family": "Aronsson", "given": "Bernice", "initials": "B"}, {"family": "Pasternak", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}], "type": "journal article", "published": "2022-08-05", "journal": {"title": "Vaccine", "issn": "1873-2518", "volume": "40", "issue": "33", "pages": "4686-4692", "issn-l": null}, "abstract": "Vaccines against SARS-CoV-2 are highly effective in preventing severe disease and mortality. Although pregnant women are at increased risk of severe COVID-19, vaccination uptake among pregnant women varies. We used the Swedish and Norwegian population-based health registries to identify pregnant women and to investigate background characteristics associated with not being vaccinated. In this study of 164 560 women giving birth between May 2021 and May 2022, 78% in Sweden and 87% in Norway have been vaccinated with at least one dose at delivery. Not being vaccinated while being pregnant was associated with age below 30 years, low education and income level, birth region other than Scandinavia, smoking during pregnancy, not living with a partner, and gestational diabetes. These results can assist health authorities develop targeted vaccination information to diminish vaccination inequality and prevent severe disease in vulnerable groups.", "doi": "10.1016/j.vaccine.2022.06.083", "pmid": "35842337", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Vaccines": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9273610"}, {"db": "pii", "key": "S0264-410X(22)00859-3"}], "notes": [], "created": "2022-08-12T08:54:24.048Z", "modified": "2023-07-13T11:30:28.895Z"}, {"entity": "publication", "iuid": "e0144e1b48894804a2c8a78d0f70a85b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e0144e1b48894804a2c8a78d0f70a85b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e0144e1b48894804a2c8a78d0f70a85b"}}, "title": "South African University Staff and Students' Perspectives, Preferences, and Drivers of Hesitancy Regarding COVID-19 Vaccines: A Multi-Methods Study.", "authors": [{"family": "George", "given": "Gavin", "initials": "G", "orcid": "0000-0001-7258-8470", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1047f3615ff7472ca7153120996b5a3d.json"}}, {"family": "Strauss", "given": "Michael", "initials": "M", "orcid": "0000-0001-7849-8812", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2460c075273474ca7b13a37b7c309ae.json"}}, {"family": "Lansdell", "given": "Emma", "initials": "E"}, {"family": "Nadesan-Reddy", "given": "Nisha", "initials": "N"}, {"family": "Moroe", "given": "Nomfundo", "initials": "N", "orcid": "0000-0001-7186-5632", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7fc9e62155c4629b1dfb65c3fc49876.json"}}, {"family": "Reddy", "given": "Tarylee", "initials": "T"}, {"family": "Eshun-Wilsonova", "given": "Ingrid", "initials": "I"}, {"family": "Moshabela", "given": "Mosa", "initials": "M"}], "type": "journal article", "published": "2022-08-04", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "COVID-19 vaccine hesitancy poses a threat to the success of vaccination programmes currently being implemented. Concerns regarding vaccine effectiveness and vaccine-related adverse events are potential barriers to vaccination; however, it remains unclear whether tailored messaging and vaccination programmes can influence uptake. Understanding the preferences of key groups, including students, could guide the implementation of youth-targeted COVID-19 vaccination programmes, ensuring optimal uptake. This study examined university staff and students' perspectives, preferences, and drivers of hesitancy regarding COVID-19 vaccines. A multi-methods approach was used-an online convenience sample survey and discrete choice experiment (DCE)-targeting staff and students at the University of KwaZulu-Natal, South Africa. The survey and DCE were available for staff and students, and data were collected from 18 November to 24 December 2021. The survey captured demographic characteristics as well as attitudes and perspectives of COVID-19 and available vaccines using modified Likert rating questions adapted from previously used tools. The DCE was embedded within the survey tool and varied critical COVID-19 vaccine programme characteristics to calculate relative utilities (preferences) and determine trade-offs. A total of 1836 staff and students participated in the study (541 staff, 1262 students, 33 undisclosed). A total of 1145 (62%) respondents reported that they had been vaccinated against COVID-19. Vaccination against COVID-19 was less prevalent among students compared with staff (79% of staff vs. 57% of students). The vaccine's effectiveness (22%), and its safety (21%), ranked as the two dominant reasons for not getting vaccinated. These concerns were also evident from the DCE, with staff and students being significantly influenced by vaccine effectiveness, with participants preferring highly effective vaccines (90% effective) as compared with those listed as being 70% or 50% effective (\u03b2 = -3.72, 95% CI = -4.39 to -3.04); this characteristic had the strongest effect on preferences of any attribute. The frequency of vaccination doses was also found to have a significant effect on preferences with participants deriving less utility from choice alternatives requiring two initial vaccine doses compared with one dose (\u03b2 = -1.00, 95% CI = -1.42 to -0.58) or annual boosters compared with none (\u03b2 = -2.35, 95% CI = -2.85 to -1.86). Notably, an incentive of ZAR 350 (USD 23.28) did have a positive utility (\u03b2 = 1.14, 95% CI = 0.76 to 1.53) as compared with no incentive. Given the slow take-up of vaccination among youth in South Africa, this study offers valuable insights into the factors that drive hesitancy among this population. Concerns have been raised around the safety and effectiveness of vaccines, although there remains a predilection for efficient services. Respondents were not enthusiastic about the prospect of having to take boosters, and this has played out in the roll-out data. Financial incentives may increase both the uptake of the initial dose of vaccines and see a more favourable response to subsequent boosters. Universities should consider tailored messaging regarding vaccine effectiveness and facilitate access to vaccines, to align services with the stated preferences of staff and students.", "doi": "10.3390/vaccines10081250", "pmid": "36016138", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "vaccines10081250"}, {"db": "pmc", "key": "PMC9412872"}], "notes": [], "created": "2022-09-12T19:11:37.572Z", "modified": "2022-09-12T19:11:37.697Z"}, {"entity": "publication", "iuid": "f1d0a53cf20a4652a557b646d63a1bfb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1d0a53cf20a4652a557b646d63a1bfb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1d0a53cf20a4652a557b646d63a1bfb"}}, "title": "Impaired physical function in patients with idiopathic inflammatory myopathies: results from the multicentre COVAD patient-reported e-survey.", "authors": [{"family": "Yoshida", "given": "Akira", "initials": "A", "orcid": "0000-0003-3590-1637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e26dfbeb7e8486a8492abc2700590df.json"}}, {"family": "Kim", "given": "Minchul", "initials": "M", "orcid": "0000-0001-9737-6255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd2952c6167b4733bfbce019a162b310.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Naveen", "given": "R", "initials": "R", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-0986-8354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2e6226ae5e7427fbf52e180dd14e28f.json"}}, {"family": "Kardes", "given": "Sinan", "initials": "S", "orcid": "0000-0002-6311-8634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2900c3ca00da476a8914574384a3c9c2.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Edgar Gracia-Ramos", "given": "Abraham", "initials": "A", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "O'Callaghan", "given": "Albert Selva", "initials": "AS", "orcid": "0000-0003-2823-9761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef3e202c049b44a2a5e045bac90a393a.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "COVAD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-08-03", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "issn-l": null}, "abstract": "The assessment of physical function is fundamental in the management of patients with idiopathic inflammatory myopathies (IIMs). We aimed to investigate the physical function of patients with IIMs compared with those with non-IIM autoimmune rheumatic diseases (AIRDs) utilizing Patient-Reported Outcome Measurement Information System (PROMIS) Physical Function (PF) data obtained in the COVAD study, an international self-reported e-survey assessing the safety of COVID-19 vaccines in AIRDs.\n\nDemographics, AIRD diagnosis, disease activity, and PROMIS PF short form-10a data were extracted from the COVAD database. PROMIS PF-10a scores were compared between disease categories and stratified by disease activity. Factors affecting PROMIS PF-10a scores other than disease activity were identified by multivariable regression analysis in patients with inactive disease.\n\n1057 IIM patients, 3635 non-IIM AIRD patients, and 3981 healthy controls (HCs) responded to the COVAD e-survey from April to August 2021. Using a binomial regression model, the predicted mean of PROMIS PF-10a scores was significantly lower in IIM patients compared with non-IIM AIRD patients or HCs (36.3 [95% confidence interval (CI) 35.5-37.1] vs 41.3 [95%CI 40.2-42.5] vs 46.2 [95%CI 45.8-46.6], P < 0.001), irrespective of disease activity. The independent factors for lower PROMIS PF-10a scores in patients with inactive disease were older age, female, longer disease duration, and a diagnosis of inclusion body myositis or polymyositis.\n\nPhysical function is significantly impaired in IIMs compared with non-IIM AIRDs or HCs, even in patients with inactive disease. Our study highlights a critical need for better strategies to minimize functional disability in patients with IIMs.", "doi": "10.1093/rheumatology/keac441", "pmid": "35920795", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6654606"}], "notes": [], "created": "2022-08-11T12:01:35.086Z", "modified": "2022-08-11T12:01:35.444Z"}, {"entity": "publication", "iuid": "8e6e2fe558dd4111892768da43c2a8f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e6e2fe558dd4111892768da43c2a8f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e6e2fe558dd4111892768da43c2a8f9"}}, "title": "Pre-pandemic Alzheimer Disease Biomarkers and Anxious-Depressive Symptoms During the COVID-19 Confinement in Cognitively Unimpaired Adults.", "authors": [{"family": "Akinci", "given": "Muge", "initials": "M"}, {"family": "Pe\u00f1a-G\u00f3mez", "given": "Cleof\u00e9", "initials": "C"}, {"family": "Operto", "given": "Gregory", "initials": "G"}, {"family": "Fuentes-Julian", "given": "Sherezade", "initials": "S"}, {"family": "Deulofeu", "given": "Carme", "initials": "C"}, {"family": "S\u00e1nchez-Benavides", "given": "Gonzalo", "initials": "G"}, {"family": "Mil\u00e0-Alom\u00e0", "given": "Marta", "initials": "M"}, {"family": "Grau-Rivera", "given": "Oriol", "initials": "O"}, {"family": "Gramunt", "given": "Nina", "initials": "N"}, {"family": "Navarro", "given": "Arcadi", "initials": "A"}, {"family": "Minguill\u00f3n", "given": "Carolina", "initials": "C"}, {"family": "Fauria", "given": "Karine", "initials": "K"}, {"family": "Suridjan", "given": "Ivonne", "initials": "I"}, {"family": "Kollmorgen", "given": "Gwendlyn", "initials": "G"}, {"family": "Bayfield", "given": "Anna", "initials": "A"}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/351fab09f6e24b9f9e6695da83947cb6.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0002-4671-6763", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79e95c490f72402196c43d602ce8e708.json"}}, {"family": "Molinuevo", "given": "Jos\u00e9 Luis", "initials": "JL"}, {"family": "Su\u00e1rez-Calvet", "given": "Marc", "initials": "M"}, {"family": "Gispert", "given": "Juan Domingo", "initials": "JD", "orcid": "0000-0002-6155-0642", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a88d83a5ca4c4a9ea428fcb3f339ca34.json"}}, {"family": "Arenaza-Urquijo", "given": "Eider M", "initials": "EM"}], "type": "journal article", "published": "2022-08-02", "journal": {"title": "Neurology", "issn": "1526-632X", "issn-l": "0028-3878"}, "abstract": "Increased anxious-depressive symptomatology is observed in the preclinical stage of Alzheimer's disease (AD), which may accelerate disease progression. We investigated whether amyloid-\u03b2, , neuroinflammation and sociodemographic factors were associated with cortical thickness in medial temporal lobe structures anxious-depressive symptoms during the COVID-19 confinement.greater\n\nThis retrospective observational study included cognitively unimpaired older adults from the ALFA (Alzheimer and FAmilies) cohort, the majority with a family history of sporadic AD. Participants performed the Hospital Anxiety and Depression Scale (HADS) during the COVID-19 confinement. A subset had available retrospective (on average: 2.4 years before) HADS assessment, amyloid [18F] flutemetamol PET and structural MRI scans and CSF markers of neuroinflammation (interleukin-6 [IL-6], triggering receptor expressed on myeloid cells 2 and glial fibrillary acidic protein levels). We performed multivariable regression models to investigate the associations of linear biomarkers and sociodemographic factors with HADS scores during the confinementpre-pandemic AD-related. . Finally, we explored the role of stress and lifestyle changes (sleep patterns, eating, drinking, smoking habits, and medication use) on the tested associations and performed sex-stratified analyses.We further performed an analysis of covariance in order to adjust by participants' pre-pandemic anxiety-depression levels\n\nWe included 921 (254 with AD biomarkers) participants. Amyloid-\u03b2 positivity (B=3.73; 95%CI=1.1 to 6.36; p=.006), caregiving (B=1.37; 95%CI=0.24 to 2.5; p=.018), sex (women: B=1.95; 95%CI=1.1 to 2.79; p<.001), younger age (B=-0.12; 95%CI=-0.18 to -0.052; p<.001) and lower education (B=-0.16; 95%CI=-0.28 to -0.042; p=.008) were associated with greater anxious-depressive symptoms during the confinement. Considering pre-pandemic anxiety-depression levels, we further observed an association between (B=-5.11; 95%CI=-10.1 to -0.13; lower levels of CSF IL-6p=.044) and HADS scores. The results were independent of stress-related variables and lifestyle changes. Stratified analysis revealed that the associations were mainly driven by women.greater\n\nOur results link AD-related pathophysiology and neuroinflammation with anxious-depressive symptomatology during the COVID-19-related confinement, notably in women. AD pathophysiology may increase neuropsychiatric symptomatology in response to stressors. This association may imply a worse clinical prognosis in people at risk for AD after the pandemic, and thus deserves to be considered by clinicians.greater\n\nClinicalTrials.gov Identifier NCT02485730.", "doi": "10.1212/WNL.0000000000200948", "pmid": "35918160", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "WNL.0000000000200948"}, {"db": "ClinicalTrials.gov", "key": "NCT02485730"}], "notes": [], "created": "2022-08-11T12:02:17.685Z", "modified": "2022-08-11T12:02:17.790Z"}, {"entity": "publication", "iuid": "2cbd31a1040043d09247c2097750ee5e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2cbd31a1040043d09247c2097750ee5e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2cbd31a1040043d09247c2097750ee5e"}}, "title": "Lockdown and No Lockdown: How Norwegian and Swedish Elite Athletes Managed Preparations for Tokyo 2020 and Mental Health Challenges in the Shadow of COVID-19.", "authors": [{"family": "Lundqvist", "given": "Carolina", "initials": "C"}, {"family": "Kristiansen", "given": "Elsa", "initials": "E"}], "type": "journal article", "published": "2022-08-02", "journal": {"title": "Front Sports Act Living", "issn": "2624-9367", "volume": "4", "pages": "918825", "issn-l": null}, "abstract": "The present study explored Norwegian and Swedish Olympic aspirants' perceived challenges for the preparations of Tokyo 2020 Olympic Games (OG) and risk and protective factors for mental health. The focus for this study was the timespan between the declaration of the postponement of Tokyo 2020 and the final months before the Games. A secondary purpose was to explore experiences of both elite athletes affected by lockdown (i.e., Norwegian athletes) and elite athletes not affected by lockdown in their home country (i.e., Swedish athletes). Twelve elite athletes (Norwegian: n = 6; Swedish: n = 6; Women: n = 6; Men: n = 6) with a mean age of 28.25 (SD = 3.60) participated. Semi-structured interviews were conducted between April and June 2021. Seven athletes had qualified and five were still trying to qualify. Eight of the interviewed athletes had previous experiences with OG participation. Template analysis revealed two main themes: (a) challenges and risk-factors for mental health and (b) protective factors. The pandemic exposed athletes to several psychological strains like uncertainty and difficulties with planning and preparations for the OG and personal and social challenges (i.e., worry about physical health and risk of overtraining, social contacts, identity, and life issues). Protective factors included perceived benefits of increased recovery and time for quality training. The athletes used several coping strategies and self-care behaviors (e.g., focus on the controllable, playfulness, putting sports in perspective, daily routines, short-term goals, working or studying for personal development) and they tapped into various internal and external psychosocial resources perceived as protective for mental health, personal growth, resiliency, and adjustment to the pandemic. The holistic perspectives used contribute to an increased understanding of elite sport athletes' mental health needs in stressful and unforeseen situations such as a pandemic.", "doi": "10.3389/fspor.2022.918825", "pmid": "35982760", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9378964"}], "notes": [], "created": "2022-09-12T18:45:36.583Z", "modified": "2022-09-12T18:45:36.595Z"}, {"entity": "publication", "iuid": "31f243e37ec049429d996fc9718824f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/31f243e37ec049429d996fc9718824f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/31f243e37ec049429d996fc9718824f7"}}, "title": "Increased incidence of childhood type 1 diabetes during the COVID-19 pandemic. Figures from an Italian tertiary care center.", "authors": [{"family": "Schiaffini", "given": "Riccardo", "initials": "R", "orcid": "0000-0002-9527-2353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5246b36ef614d9fb2ceb112e0cd80ba.json"}}, {"family": "Deodati", "given": "Annalisa", "initials": "A"}, {"family": "Rapini", "given": "Novella", "initials": "N"}, {"family": "Pampanini", "given": "Valentina", "initials": "V"}, {"family": "Cianfarani", "given": "Stefano", "initials": "S"}], "type": "letter", "published": "2022-08-02", "journal": {"title": "J Diabetes", "issn": "1753-0407", "issn-l": null}, "abstract": null, "doi": "10.1111/1753-0407.13298", "pmid": "35916392", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-11T12:02:59.090Z", "modified": "2022-08-11T12:02:59.148Z"}, {"entity": "publication", "iuid": "115d909766f44e4db43983d9bbdeb689", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/115d909766f44e4db43983d9bbdeb689.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/115d909766f44e4db43983d9bbdeb689"}}, "title": "Computational models predicting the early development of the COVID-19 pandemic in Sweden: systematic review, data synthesis, and secondary validation of accuracy", "authors": [{"family": "Gerlee", "given": "Philip", "initials": "P", "orcid": "0000-0001-8503-0177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ba426c1ab741e781d2b9cd09a0b830.json"}}, {"family": "J\u00f6ud", "given": "Anna", "initials": "A", "orcid": "0000-0001-7192-4911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e038a5ce2f5a47bd89e7c221651a3d24.json"}}, {"family": "Spreco", "given": "Armin", "initials": "A"}, {"family": "Timpka", "given": "Toomas", "initials": "T"}], "type": "journal-article", "published": "2022-08-02", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "13256", "issn-l": "2045-2322"}, "abstract": "Computational models for predicting the early course of the COVID-19 pandemic played a central role in policy-making at regional and national levels. We performed a systematic review, data synthesis, and secondary validation of studies that reported on prediction models addressing the early stages of the COVID-19 pandemic in Sweden. A literature search in January 2021 based on the search triangle model identified 1672 peer-reviewed articles, preprints and reports. After applying inclusion criteria 52 studies remained out of which 12 passed a Risk of Bias Opinion Tool. When comparing model predictions with actual outcomes only 4 studies exhibited an acceptable forecast (mean absolute percentage error, MAPE < 20%). Models that predicted disease incidence could not be assessed due to the lack of reliable data during 2020. Drawing conclusions about the accuracy of the models with acceptable methodological quality was challenging because some models were published before the time period for the prediction, while other models were published during the prediction period or even afterwards. We conclude that the forecasting models involving Sweden developed during the early stages of the COVID-19 pandemic in 2020 had limited accuracy. The knowledge attained in this study can be used to improve the preparedness for coming pandemics.", "doi": "10.1038/s41598-022-16159-6", "pmid": "35918476", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9345013"}, {"db": "pii", "key": "10.1038/s41598-022-16159-6"}], "notes": [], "created": "2022-08-11T12:01:58.698Z", "modified": "2023-06-19T14:58:56.393Z"}, {"entity": "publication", "iuid": "c3a29385ba7848e4b7dae4b8db98a818", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3a29385ba7848e4b7dae4b8db98a818.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3a29385ba7848e4b7dae4b8db98a818"}}, "title": "The Role of Neutrophil-to-Lymphocyte Ratio in Risk Stratification and Prognostication of COVID-19: A Systematic Review and Meta-Analysis.", "authors": [{"family": "Parthasarathi", "given": "Ashwaghosha", "initials": "A", "orcid": "0000-0002-7270-0247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c0a5e6837a421cbbb0314628ae7f24.json"}}, {"family": "Padukudru", "given": "Sunag", "initials": "S", "orcid": "0000-0003-4088-9548", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/815e161a476946c689f312fd8986b5a0.json"}}, {"family": "Arunachal", "given": "Sumalata", "initials": "S"}, {"family": "Basavaraj", "given": "Chetak Kadabasal", "initials": "CK"}, {"family": "Krishna", "given": "Mamidipudi Thirumala", "initials": "MT", "orcid": "0000-0003-2109-5777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cfbac9ab1b3c4afea2f7de6b60fd162a.json"}}, {"family": "Ganguly", "given": "Koustav", "initials": "K", "orcid": "0000-0001-8531-8154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58b2e0d7853a4b32920e54042e95061d.json"}}, {"family": "Upadhyay", "given": "Swapna", "initials": "S"}, {"family": "Anand", "given": "Mahesh Padukudru", "initials": "MP"}], "type": "journal article", "published": "2022-08-01", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "Several studies have proposed that the neutrophil-lymphocyte ratio (NLR) is one of the various biomarkers that can be useful in assessing COVID-19 disease-related outcomes. Our systematic review analyzes the relationship between on-admission NLR values and COVID-19 severity and mortality. Six different severity criteria were used. A search of the literature in various databases was conducted from 1 January 2020 to 1 May 2021. We calculated the pooled standardized mean difference (SMD) for the collected NLR values. A meta-regression analysis was performed, looking at the length of hospitalization and other probable confounders, such as age, gender, and comorbidities. A total of sixty-four studies were considered, which included a total of 15,683 patients. The meta-analysis showed an SMD of 3.12 (95% CI: 2.64-3.59) in NLR values between severe and non-severe patients. A difference of 3.93 (95% CI: 2.35-5.50) was found between survivors and non-survivors of the disease. Upon summary receiver operating characteristics analysis, NLR showed 80.2% (95% CI: 74.0-85.2%) sensitivity and 75.8% (95% CI: 71.3-79.9%) specificity for the prediction of severity and 78.8% (95% CI: 73.5-83.2%) sensitivity and 73.0% (95% CI: 68.4-77.1%) specificity for mortality, and was not influenced by age, gender, or co-morbid conditions. Conclusion: On admission, NLR predicts both severity and mortality in COVID-19 patients, and an NLR &gt; 6.5 is associated with significantly greater the odds of mortality.", "doi": "10.3390/vaccines10081233", "pmid": "36016121", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "vaccines10081233"}, {"db": "pmc", "key": "PMC9415708"}], "notes": [], "created": "2022-09-12T19:11:18.061Z", "modified": "2022-09-12T19:11:18.188Z"}, {"entity": "publication", "iuid": "f6ab87d2afb44facbaa5e35b6a5dcb4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6ab87d2afb44facbaa5e35b6a5dcb4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6ab87d2afb44facbaa5e35b6a5dcb4d"}}, "title": "Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia.", "authors": [{"family": "Zhang", "given": "Qian", "initials": "Q", "orcid": "0000-0002-9040-3289", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/341c0cb0fa7d41448e55344c82d68358.json"}}, {"family": "Matuozzo", "given": "Daniela", "initials": "D", "orcid": "0000-0001-9514-3837", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f3ea98ae5ed468a81d92fd3c5d4782b.json"}}, {"family": "Le Pen", "given": "J\u00e9r\u00e9mie", "initials": "J", "orcid": "0000-0001-7025-9526", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/419c9219d4664b899addbcdde33b7551.json"}}, {"family": "Lee", "given": "Danyel", "initials": "D", "orcid": "0000-0003-3124-0245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a658026d0b444541bc6fa15b1de790ec.json"}}, {"family": "Moens", "given": "Leen", "initials": "L", "orcid": "0000-0002-5347-6526", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49147a953e1c4721bd0181e5d0a3dafb.json"}}, {"family": "Asano", "given": "Takaki", "initials": "T", "orcid": "0000-0003-1424-2433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cce1fe0e7df44b2a7a49fbcb45b1a5a.json"}}, {"family": "Bohlen", "given": "Jonathan", "initials": "J", "orcid": "0000-0003-0458-9484", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9aedda86e36413883cc6558c66727e1.json"}}, {"family": "Liu", "given": "Zhiyong", "initials": "Z", "orcid": "0000-0001-6473-348X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d7b2869a5874679b1b6fdccade088a2.json"}}, {"family": "Moncada-Velez", "given": "Marcela", "initials": "M", "orcid": "0000-0002-3073-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c543a8539a6430b8ff5cd9cf5875bf9.json"}}, {"family": "Kendir-Demirkol", "given": "Yasemin", "initials": "Y", "orcid": "0000-0001-8016-5224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d48a0443bd049bea3e4ab80b48239c3.json"}}, {"family": "Jing", "given": "Huie", "initials": "H", "orcid": "0000-0001-6283-3452", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8904017c1a114ad7aa4a64850450f299.json"}}, {"family": "Bizien", "given": "Lucy", "initials": "L", "orcid": "0000-0001-9163-9122", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ffde5891cfed41db9dc0265155576cc4.json"}}, {"family": "Marchal", "given": "Astrid", "initials": "A", "orcid": "0000-0003-0648-8126", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbf87e3c4eb34dadb828c6f58276e8b0.json"}}, {"family": "Abolhassani", "given": "Hassan", "initials": "H", "orcid": "0000-0002-4838-0407", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36fb362d046748b0a62822960ce20edd.json"}}, {"family": "Delafontaine", "given": "Selket", "initials": "S", "orcid": "0000-0002-8985-8155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/505e15f7fd9e41d3b3f3a9fa8bb3a123.json"}}, {"family": "Bucciol", "given": "Giorgia", "initials": "G", "orcid": "0000-0001-5004-0738", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fde316a981d84407a32dca71fd6f39ba.json"}}, {"family": "COVID Human Genetic Effort", "given": "", "initials": ""}, {"family": "Bayhan", "given": "Gulsum Ical", "initials": "GI", "orcid": "0000-0002-1423-4348", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/974e5811368646b5a90ccc027212db3d.json"}}, {"family": "Keles", "given": "Sevgi", "initials": "S", "orcid": "0000-0001-7344-8947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08e51d507698439cbf08326d10be2310.json"}}, {"family": "Kiykim", "given": "Ayca", "initials": "A", "orcid": "0000-0001-5821-3963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/999518defe2c4fabb42480ccef8ad8c0.json"}}, {"family": "Hancerli", "given": "Selda", "initials": "S", "orcid": "0000-0002-3216-2413", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7414c31e5b704991a1e81912d14eddc8.json"}}, {"family": "Haerynck", "given": "Filomeen", "initials": "F", "orcid": "0000-0001-9161-7361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbe7ce932ab14405b7ad1c1153d39972.json"}}, {"family": "Florkin", "given": "Benoit", "initials": "B", "orcid": "0000-0001-7318-8348", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc4ebf10fd104544803675f66863291b.json"}}, {"family": "Hatipoglu", "given": "Nevin", "initials": "N", "orcid": "0000-0003-2858-0150", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c14f98b8f5e24280a669fa49a297c3dc.json"}}, {"family": "Ozcelik", "given": "Tayfun", "initials": "T", "orcid": "0000-0001-5937-1082", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6665d35db77044aa847a5f394332bb86.json"}}, {"family": "Morelle", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-6511-1674", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0ef829b533e45edb15a3e5c03c2db65.json"}}, {"family": "Zatz", "given": "Mayana", "initials": "M", "orcid": "0000-0003-3970-8025", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d37e5fa0191b433386921fff2e34245b.json"}}, {"family": "Ng", "given": "Lisa F P", "initials": "LFP", "orcid": "0000-0003-4071-5222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0502452f11bf44ba96a6cb952a82a1f5.json"}}, {"family": "Lye", "given": "David Chien", "initials": "DC", "orcid": "0000-0003-0324-0205", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d274935e03904ae2935f07246404d97d.json"}}, {"family": "Young", "given": "Barnaby Edward", "initials": "BE", "orcid": "0000-0003-1010-2230", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/319b1cd3f3b540edb9f9651160eefcb3.json"}}, {"family": "Leo", "given": "Yee-Sin", "initials": "YS", "orcid": "0000-0003-4978-5825", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ca28661a9df44a7b95577da156b54c9.json"}}, {"family": "Dalgard", "given": "Clifton L", "initials": "CL", "orcid": "0000-0003-2025-8239", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22f57b7602714f59bfbcc96a936d77a8.json"}}, {"family": "Lifton", "given": "Richard P", "initials": "RP", "orcid": "0000-0002-5745-5984", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/354dc2abf2a04896b69ef5cba011679f.json"}}, {"family": "Renia", "given": "Laurent", "initials": "L", "orcid": "0000-0003-0349-1557", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/957c86bd7cc941e0a2e7c7de9817e5ce.json"}}, {"family": "Meyts", "given": "Isabelle", "initials": "I", "orcid": "0000-0003-1214-0302", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a5399449f4c4d338b683632944008fb.json"}}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E", "orcid": "0000-0002-7358-9157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c50d261245743539a5813daffcaab72.json"}}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L", "orcid": "0000-0002-8635-9609", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b532108235c415891981621f58ddbfd.json"}}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q", "orcid": "0000-0003-1990-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94a32366862b470eba3a15521b9be290.json"}}, {"family": "Boisson", "given": "Bertrand", "initials": "B", "orcid": "0000-0001-5240-3555", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1dc2dc22a5d240dc889707226eb18a36.json"}}, {"family": "Bastard", "given": "Paul", "initials": "P", "orcid": "0000-0002-5926-8437", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e3388c840d04a25824530a9bf999f01.json"}}, {"family": "Su", "given": "Helen C", "initials": "HC", "orcid": "0000-0002-5582-9110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad550813f03540d9a8240a3d96ad0829.json"}}, {"family": "Boisson-Dupuis", "given": "St\u00e9phanie", "initials": "S", "orcid": "0000-0002-7115-116X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92c785f151bb490aa85764eb62c0508e.json"}}, {"family": "Abel", "given": "Laurent", "initials": "L", "orcid": "0000-0001-7016-6493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fd6c4593c8c492a8dad8e49cb7a832a.json"}}, {"family": "Rice", "given": "Charles M", "initials": "CM", "orcid": "0000-0003-3087-8079", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb21eff3730f4b64a8ebed8b04a9038c.json"}}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY", "orcid": "0000-0002-9449-3672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/273e17cf54524572baff11761631d846.json"}}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5369fe152ac94b5a81d4f913d85940a7.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL", "orcid": "0000-0002-7782-4169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1aca66ab7c39465faf2de03fa8a6722f.json"}}], "type": "journal article", "published": "2022-08-01", "journal": {"title": "J Exp Med", "issn": "1540-9538", "volume": "219", "issue": "8", "issn-l": null}, "abstract": "Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical COVID-19 pneumonia in unvaccinated adults. The risk of COVID-19 pneumonia in unvaccinated children, which is much lower than in unvaccinated adults, remains unexplained. In an international cohort of 112 children (<16 yr old) hospitalized for COVID-19 pneumonia, we report 12 children (10.7%) aged 1.5-13 yr with critical (7 children), severe (3), and moderate (2) pneumonia and 4 of the 15 known clinically recessive and biochemically complete inborn errors of type I IFN immunity: X-linked recessive TLR7 deficiency (7 children) and autosomal recessive IFNAR1 (1), STAT2 (1), or TYK2 (3) deficiencies. Fibroblasts deficient for IFNAR1, STAT2, or TYK2 are highly vulnerable to SARS-CoV-2. These 15 deficiencies were not found in 1,224 children and adults with benign SARS-CoV-2 infection without pneumonia (P = 1.2 \u00d7 10-11) and with overlapping age, sex, consanguinity, and ethnicity characteristics. Recessive complete deficiencies of type I IFN immunity may underlie \u223c10% of hospitalizations for COVID-19 pneumonia in children.", "doi": "10.1084/jem.20220131", "pmid": "35708626", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "213287"}, {"db": "pmc", "key": "PMC9206114"}], "notes": [], "created": "2022-06-20T18:08:01.020Z", "modified": "2022-08-17T12:48:34.870Z"}, {"entity": "publication", "iuid": "6deffae81fdc4c21bf7b2b1d630eff8f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6deffae81fdc4c21bf7b2b1d630eff8f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6deffae81fdc4c21bf7b2b1d630eff8f"}}, "title": "Pharmacovigilance regulatory actions by national pharmacovigilance centres in Arab countries following COVID-19 pandemic.", "authors": [{"family": "Al-Zubiedi", "given": "Sameh A", "initials": "SA", "orcid": "0000-0003-0888-5328", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/686c3af4ef524cdfbcedbae63dba9c77.json"}}, {"family": "Younus", "given": "Manal", "initials": "M"}, {"family": "Al-Khalidi", "given": "Sara", "initials": "S"}, {"family": "Ekilo", "given": "Magnus", "initials": "M"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM", "orcid": "0000-0002-5630-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5162aab03bc04dafa809108461f18667.json"}}], "type": "journal article", "published": "2022-08-01", "journal": {"title": "Expert Opin Drug Saf", "issn": "1744-764X", "issn-l": null}, "abstract": "Pharmacovigilance (PV) activities were affected by COVID-19. Therefore, several health authorities around the world have issued guidelines and practices to ensure that PV activities are maintained and continued during the pandemic. This study aimed to assess the impact of COVID-19 on the preparedness and performance of national PV systems in 14 Arab countries.\n\nThis was a cross-sectional study that was conducted between July and October 2020. National PV centres in 18 Arab countries were invited to participate in this study. Descriptive analysis was used to summarize and present the results of this study.\n\nResponses were obtained from 14 (77.8%) countries. Adverse events reporting was the main PV activity that was covered by PV guidelines and practices. National guidelines and practices covered other PV activities in 8 (57.14%) of the participating countries. Performance and practices of national PV centres vary considerably among participating countries during the pandemic.\n\nThe findings highlight the differences in preparedness and performance of different national PV centres in participating Arab countries. Improving digital infrastructure among participating countries could serve as a useful tool to minimize the impact of the pandemic on PV activities.", "doi": "10.1080/14740338.2022.2108398", "pmid": "35915555", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-08-11T12:03:26.248Z", "modified": "2022-08-11T12:03:26.339Z"}, {"entity": "publication", "iuid": "736b58cbf52142a6926bd2b650b86d2b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/736b58cbf52142a6926bd2b650b86d2b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/736b58cbf52142a6926bd2b650b86d2b"}}, "title": "Ion channel inhibition with amiodarone or verapamil in symptomatic hospitalized nonintensive-care COVID-19 patients: The ReCOVery-SIRIO randomized trial.", "authors": [{"family": "Navarese", "given": "Eliano P", "initials": "EP"}, {"family": "Podhajski", "given": "Przemys\u0142aw", "initials": "P"}, {"family": "Andreotti", "given": "Felicita", "initials": "F"}, {"family": "La Torre", "given": "Giuseppe", "initials": "G"}, {"family": "Gajda", "given": "Robert", "initials": "R"}, {"family": "Radziwanowski", "given": "Adrian", "initials": "A"}, {"family": "Nowicka", "given": "Ma\u0142gorzata", "initials": "M"}, {"family": "Bukowski", "given": "Pawe\u0142", "initials": "P"}, {"family": "Gajda", "given": "Jacek", "initials": "J"}, {"family": "Omy\u0142a", "given": "Maciej", "initials": "M"}, {"family": "Lackowski", "given": "Piotr", "initials": "P"}, {"family": "Piasecki", "given": "Maciej", "initials": "M"}, {"family": "Jasiewicz", "given": "Ma\u0142gorzata", "initials": "M"}, {"family": "Szyma\u0144ski", "given": "Pawe\u0142", "initials": "P"}, {"family": "Pietrzykowski", "given": "\u0141ukasz", "initials": "\u0141"}, {"family": "Michalski", "given": "Piotr", "initials": "P"}, {"family": "Kubica", "given": "Aldona", "initials": "A"}, {"family": "Urbanowicz", "given": "Iwona", "initials": "I"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}, {"family": "Conte", "given": "Max", "initials": "M"}, {"family": "Pinkas", "given": "Jaros\u0142aw", "initials": "J"}, {"family": "Brouwer", "given": "Marc A", "initials": "MA"}, {"family": "Kubica", "given": "Jacek", "initials": "J"}], "type": "journal article", "published": "2022-08-01", "journal": {"title": "Cardiol J", "issn": "1898-018X", "issn-l": null}, "abstract": "Ion channel inhibition may offer protection against coronavirus disease 2019 (COVID-19). Inflammation and reduced platelet count occur during COVID-19 but precise quantification of risk thresholds is unclear. The Recovery-SIRIO study aimed to assess clinical effects of amiodarone and verapamil and to relate patient phenotypes to outcomes.\n\nRECOVERY-SIRIO is a multicenter open-label 1:1:1 investigator-initiated randomized trial with blinded event adjudication. A sample of 804 symptomatic hospitalized nonintensive-care COVID-19 patients, follow-up for 28 days was initially planned.\n\nThe trial was stopped when a total of 215 patients had been randomized to amiodarone (n = 71), verapamil (n = 72) or standard care alone (n = 72). At 15 days, the hazard ratio (hazard ratio [HR], 95% confidence interval [CI]) for clinical improvement was 0.77 (0.52-1.14) with amiodarone and 0.97 (0.81-1.17) with verapamil as compared to usual care. Clinically relevant associations were found between mortality or lack of clinical improvement and higher peak C-reactive protein (CRP) levels or nadir platelet count at 7, 10 and 15 days. Mortality rate increased by 73% every 5 mg/dL increment in peak CRP (HR 1.73, 95% CI 1.27-2.37) and was two-fold higher for every decrement of 100 units in nadir platelet count (HR 2.19, 95% CI 1.37-3.51). By cluster analysis, thresholds of 5 mg/dL for peak CRP and 187 \u00d710\u00b3/mcL for nadir platelet count identified the phenogroup at greatest risk of dying.\n\nIn this randomized trial, neither amiodarone nor verapamil were found to significantly accelerate short-term clinical improvement. Peak CRP and nadir platelet counts were associated with increased mortality both in isolation and by cluster analysis.", "doi": "10.5603/CJ.a2022.0072", "pmid": "35912711", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "VM/OJS/J/88627"}], "notes": [], "created": "2022-08-11T12:04:30.224Z", "modified": "2022-08-11T12:04:30.261Z"}, {"entity": "publication", "iuid": "c74a65a0291343bcb2edbb2ba2f7f3c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c74a65a0291343bcb2edbb2ba2f7f3c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c74a65a0291343bcb2edbb2ba2f7f3c0"}}, "title": "Can aerosols-generating dental, oral and maxillofacial, and orthopedic surgical procedures lead to disease transmission? An implication on the current COVID-19 pandemic.", "authors": [{"family": "Al-Moraissi", "given": "Essam Ahmed", "initials": "EA"}, {"family": "Kaur", "given": "Amanjot", "initials": "A"}, {"family": "G\u00fcnther", "given": "Frank", "initials": "F"}, {"family": "Neff", "given": "Andreas", "initials": "A"}, {"family": "Christidis", "given": "Nikolaos", "initials": "N"}], "type": "systematic review", "published": "2022-08-01", "journal": {"title": "Front Oral Health", "issn": "2673-4842", "volume": "3", "pages": "974644", "issn-l": null}, "abstract": "Various dental, maxillofacial, and orthopedic surgical procedures (DMOSP) have been known to produce bioaerosols, that can lead to the transmission of various infectious diseases. Hence, a systematic review (SR) aimed at generating evidence of aerosols generating DMOSP that can result in the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), further investigating their infectivity and assessing the role of enhanced personal protective equipment (PPE) an essential to preventing the spreading of SARS-CoV-2 during aerosol-generating procedures (AGPs). This SR was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (PRISMA) guidelines based on a well-designed Population, Intervention, Comparison, Outcomes and Study (PICOS) framework, and various databases were searched to retrieve the studies which assessed potential aerosolization during DMOSP. This SR included 80 studies (59 dental and 21 orthopedic) with 7 SR, 47 humans, 5 cadaveric, 16 experimental, and 5 animal studies that confirmed the generation of small-sized < 5 \u03bcm particles in DMOSP. One study confirmed that HIV could be transmitted by aerosolized blood generated by an electric saw and bur. There is sufficient evidence that DMOSP generates an ample amount of bioaerosols, but the infectivity of these bioaerosols to transmit diseases like SARS-CoV-2 generates very weak evidence but still, this should be considered. Confirmation through isolation and culture of viable virus in the clinical environment should be pursued. An evidence provided by the current review was gathered by extrapolation from available experimental and empirical evidence not based on SARS-CoV-2. The results of the present review, therefore, should be interpreted with great caution.", "doi": "10.3389/froh.2022.974644", "pmid": "35979536", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9376374"}], "notes": [], "created": "2022-09-12T18:41:22.127Z", "modified": "2022-09-12T18:41:32.412Z"}, {"entity": "publication", "iuid": "6c5019a8ad1f4e78beb9ad8e3f80fb4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c5019a8ad1f4e78beb9ad8e3f80fb4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c5019a8ad1f4e78beb9ad8e3f80fb4d"}}, "title": "Acute pericarditis in patients receiving coronavirus disease 2019 vaccines: a case series from the community.", "authors": [{"family": "Dini", "given": "Frank L", "initials": "FL"}, {"family": "Franzoni", "given": "Ferdinando", "initials": "F"}, {"family": "Scarf\u00f2", "given": "Giorgia", "initials": "G"}, {"family": "Pugliese", "given": "Nicola Riccardo", "initials": "NR"}, {"family": "Imazio", "given": "Massimo", "initials": "M"}], "type": "journal article", "published": "2022-08-01", "journal": {"title": "J Cardiovasc Med (Hagerstown)", "issn": "1558-2035", "volume": "23", "issue": "8", "pages": "551-558", "issn-l": null}, "abstract": "International agencies reported that cases of pericarditis occur very rarely following the administration of coronavirus disease 2019 (COVID-19) vaccines. Herewith, we described a series of patients from the community diagnosed with acute pericarditis after vaccination.\n\nWe retrospectively included 28 patients (median age 51 years, 79% female) with or without a positive history of acute respiratory syndrome coronavirus 2 recovered infection who were diagnosed with acute pericarditis following the administration of COVID-19 vaccine. We excluded specific identifiable causes of pericarditis, including infectious, autoimmune, neoplastic and metabolic disease. Patients were referred for a complete cardiovascular evaluation. Transthoracic echocardiography (TTE) was performed and diagnosis of acute pericarditis was achieved according to current guidelines.\n\nThere were 16 patients administered with Pfizer-BioNTech/Comirnaty vaccine, 8 with Moderna/Spikevax vaccine and 4 with Astra Zeneca/Vaxzevria vaccine. Nine patients had been previously diagnosed with COVID-19, while the others had no prior history of COVID-19. Eleven patients had no comorbidity while the others had between one and four comorbidities. Ten patients had a history of rheumatic or autoimmune diseases. Chest pain was present in 24 patients. Minor ECG abnormalities were detected in 10 patients, T-wave inversion in 6, and 7 patients had concave ST elevation. The majority of patients showed mild pericardial effusions at TTE. Only two patients exhibited large pericardial effusions.\n\nThis case series shows a higher incidence of acute pericarditis in patients administered with COVID-19 vaccines than previously estimated, probably because of a more comprehensive assessment of clinical as well as echocardiographic parameters.", "doi": "10.2459/JCM.0000000000001342", "pmid": "35904995", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "01244665-990000000-00028"}], "notes": [], "created": "2022-08-12T08:31:22.928Z", "modified": "2022-08-12T08:31:22.933Z"}, {"entity": "publication", "iuid": "68b51851f33c4f63b18049d8f560ce50", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68b51851f33c4f63b18049d8f560ce50.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68b51851f33c4f63b18049d8f560ce50"}}, "title": "Zanubrutinib versus bendamustine and rituximab in untreated chronic lymphocytic leukaemia and small lymphocytic lymphoma (SEQUOIA): a randomised, controlled, phase 3 trial.", "authors": [{"family": "Tam", "given": "Constantine S", "initials": "CS"}, {"family": "Brown", "given": "Jennifer R", "initials": "JR"}, {"family": "Kahl", "given": "Brad S", "initials": "BS"}, {"family": "Ghia", "given": "Paolo", "initials": "P"}, {"family": "Giannopoulos", "given": "Krzysztof", "initials": "K"}, {"family": "Jurczak", "given": "Wojciech", "initials": "W"}, {"family": "\u0160imkovi\u010d", "given": "Martin", "initials": "M"}, {"family": "Shadman", "given": "Mazyar", "initials": "M"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Laurenti", "given": "Luca", "initials": "L"}, {"family": "Walker", "given": "Patricia", "initials": "P"}, {"family": "Opat", "given": "Stephen", "initials": "S"}, {"family": "Chan", "given": "Henry", "initials": "H"}, {"family": "Ciepluch", "given": "Hanna", "initials": "H"}, {"family": "Greil", "given": "Richard", "initials": "R"}, {"family": "Tani", "given": "Monica", "initials": "M"}, {"family": "Trn\u011bn\u00fd", "given": "Marek", "initials": "M"}, {"family": "Brander", "given": "Danielle M", "initials": "DM"}, {"family": "Flinn", "given": "Ian W", "initials": "IW"}, {"family": "Grosicki", "given": "Sebastian", "initials": "S"}, {"family": "Verner", "given": "Emma", "initials": "E"}, {"family": "Tedeschi", "given": "Alessandra", "initials": "A"}, {"family": "Li", "given": "Jianyong", "initials": "J"}, {"family": "Tian", "given": "Tian", "initials": "T"}, {"family": "Zhou", "given": "Lei", "initials": "L"}, {"family": "Marimpietri", "given": "Carol", "initials": "C"}, {"family": "Paik", "given": "Jason C", "initials": "JC"}, {"family": "Cohen", "given": "Aileen", "initials": "A"}, {"family": "Huang", "given": "Jane", "initials": "J"}, {"family": "Robak", "given": "Tadeusz", "initials": "T"}, {"family": "Hillmen", "given": "Peter", "initials": "P"}], "type": "clinical trial, phase iii", "published": "2022-08-00", "journal": {"title": "Lancet Oncol", "issn": "1474-5488", "volume": "23", "issue": "8", "pages": "1031-1043", "issn-l": null}, "abstract": "Zanubrutinib is a next-generation, selective Bruton tyrosine kinase inhibitor with efficacy in relapsed chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). We compared zanubrutinib with bendamustine-rituximab to determine its effectiveness as frontline therapy in patients with CLL or SLL.\n\nWe conducted an open-label, multicentre, phase 3 study at 153 academic or community hospitals in 14 countries and regions. Eligible patients had untreated CLL or SLL requiring treatment as per International Workshop on CLL criteria; were aged 65 years or older, or 18 years or older and had comorbidities; and had an Eastern Cooperative Oncology Group performance status score of 0-2. A central interactive web response system randomly assigned patients without del(17)(p13\u00b71) to zanubrutinib (group A) or bendamustine-rituximab (group B) by sequential block method (permutated blocks with a random block size of four). Patients with del(17)(p13\u00b71) were enrolled in group C and received zanubrutinib. Zanubrutinib was administered orally at 160 mg twice per day (28-day cycles); bendamustine at 90 mg/m2 of body surface area on days 1 and 2 for six cycles plus rituximab at 375 mg/m2 of body surface area the day before or on day 1 of cycle 1, and 500 mg/m2 of body surface area on day 1 of cycles 2-6, were administered intravenously. The primary endpoint was progression-free survival per independent review committee in the intention-to-treat population in groups A and B, with minimum two-sided \u03b1 of 0\u00b705 for superiority. Safety was analysed in all patients who received at least one dose of study treatment. The study is registered with ClinicalTrials.gov, NCT03336333, and is closed to recruitment.\n\nBetween Oct 31, 2017, and July 22, 2019, 590 patients were enrolled; patients without del(17)(p13\u00b71) were randomly assigned to zanubrutinib (group A; n=241) or bendamustine-rituximab (group B; n=238). At median follow-up of 26\u00b72 months (IQR 23\u00b77-29\u00b76), median progression-free survival per independent review committee was not reached in either group (group A 95% CI not estimable [NE] to NE; group B 28\u00b71 months to NE). Progression-free survival was significantly improved in group A versus group B (HR 0\u00b742 [95% CI 0\u00b728 to 0\u00b763]; two-sided p<0\u00b70001). The most common grade 3 or worse adverse event was neutropenia (27 [11%] of 240 patients in group A, 116 [51%] of 227 in group B, and 17 [15%] of 111 patients in group C). Serious adverse events occurred in 88 (37%) of 240 patients in group A, 113 (50%) of 227 patients in group B, and 45 (41%) of 111 patients in group C. Adverse events leading to death occurred in 11 (5%) of 240 patients in group A, 12 (5%) of 227 patients in group B, and three (3%) of 111 patients in group C, most commonly due to COVID-19 (four [2%] of 240 patients in group A), diarrhoea, and aspiration pneumonia (two each [1%] of 227 patients in group B).\n\nZanubrutinib significantly improved progression-free survival versus bendamustine-rituximab, with an acceptable safety profile consistent with previous studies. These data support zanubrutinib as a potential new treatment option for untreated CLL and SLL.\n\nBeiGene.", "doi": "10.1016/S1470-2045(22)00293-5", "pmid": "35810754", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1470-2045(22)00293-5"}, {"db": "ClinicalTrials.gov", "key": "NCT03336333"}], "notes": [], "created": "2022-08-17T10:39:58.703Z", "modified": "2022-08-17T10:39:58.741Z"}, {"entity": "publication", "iuid": "0e5238a4af7444efb0b085cb8e289129", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e5238a4af7444efb0b085cb8e289129.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e5238a4af7444efb0b085cb8e289129"}}, "title": "Young children's voices in an unlocked Sweden during the COVID-19 pandemic.", "authors": [{"family": "Jenholt Nolbris", "given": "M", "initials": "M", "orcid": "0000-0002-6911-1484", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f53d9c5dc5ff46149ef63e16dfa6d7a1.json"}}, {"family": "Ragnarsson", "given": "S", "initials": "S", "orcid": "0000-0002-0646-7184", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44ffe0f652d74510b8caa74f9fb1c01f.json"}}, {"family": "Brorsson", "given": "A-L", "initials": "AL", "orcid": "0000-0002-8136-6340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bdee85ca7c74d93a2881e22997192b7.json"}}, {"family": "Garcia de Avila", "given": "M", "initials": "M", "orcid": "0000-0002-6652-4427", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b1e6b2121ac40969728034efca6c6a9.json"}}, {"family": "Forsner", "given": "M", "initials": "M"}, {"family": "Kull", "given": "I", "initials": "I"}, {"family": "Olinder", "given": "A L", "initials": "AL"}, {"family": "Mattson", "given": "J", "initials": "J"}, {"family": "Nilsson", "given": "S", "initials": "S"}, {"family": "Rullander", "given": "A-C", "initials": "AC"}, {"family": "Rydstr\u00f6m", "given": "L-L", "initials": "LL", "orcid": "0000-0002-1007-1959", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad5251de283d4f73b0c2ac600a34a19a.json"}}, {"family": "Olaya-Contreras", "given": "P", "initials": "P"}, {"family": "Berghammer", "given": "M", "initials": "M"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "volume": "50", "issue": "6", "pages": "693-702", "issn-l": "1403-4948"}, "abstract": "During the COVID-19 pandemic, Sweden was one of the few countries that rejected lockdowns in favour of recommendations for restrictions, including careful hand hygiene and social distancing. Preschools and primary schools remained open. Several studies have shown negative impacts of the pandemic on children, particularly high levels of anxiety. The study aim was to explore how Swedish school-aged children aged 6-14 years, experienced the COVID-19 pandemic and their perceived anxiety.\n\nIn total, 774 children aged 6-14 years and their guardians answered an online questionnaire containing 24 questions, along with two instruments measuring anxiety: the Children's Anxiety Questionnaire and the Numerical Rating Scale. A convergent parallel mixed-methods design was used for analysing the quantitative and qualitative data. Each data source was first analysed separately, followed by a merged interpretative analysis.\n\nThe results showed generally low levels of anxiety, with no significant sex differences. Children who refrained from normal social activities or group activities (n=377) had significantly higher levels of anxiety. Most of the children were able to appreciate the bright side of life, despite the social distancing and refraining from activities, which prevented them from meeting and hugging their loved ones.\n\nThese Swedish children generally experienced low levels of anxiety, except those who refrained from social activities. Life was nonetheless mostly experienced as normal, largely because schools remained open. Keeping life as normal as possible could be one important factor in preventing higher anxiety and depression levels in children during a pandemic.", "doi": "10.1177/14034948221108250", "pmid": "35799462", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9361420"}], "notes": [], "created": "2022-08-17T10:45:35.107Z", "modified": "2023-01-13T13:37:17.582Z"}, {"entity": "publication", "iuid": "61c32411a7c54756878158ee59df6fed", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61c32411a7c54756878158ee59df6fed.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61c32411a7c54756878158ee59df6fed"}}, "title": "Validation of a noninvasive aMMP-8 point-of-care diagnostic methodology in COVID-19 patients with periodontal disease.", "authors": [{"family": "Gupta", "given": "Shipra", "initials": "S", "orcid": "0000-0003-2097-2459", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa6dd4cea3824827b3ead550b8267b2a.json"}}, {"family": "Mohindra", "given": "Ritin", "initials": "R"}, {"family": "Singla", "given": "Mohita", "initials": "M"}, {"family": "Khera", "given": "Sagar", "initials": "S"}, {"family": "Kumar", "given": "Amit", "initials": "A"}, {"family": "Rathnayake", "given": "Nilminie", "initials": "N"}, {"family": "Sorsa", "given": "Timo", "initials": "T"}, {"family": "Pf\u00fctzner", "given": "Andreas", "initials": "A"}, {"family": "R\u00e4is\u00e4nen", "given": "Ismo T", "initials": "IT", "orcid": "0000-0001-5821-5299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5688183e182e4194888dc98301077bab.json"}}, {"family": "Soni", "given": "Roop K", "initials": "RK"}, {"family": "Kanta", "given": "Poonam", "initials": "P"}, {"family": "Jain", "given": "Akanksha", "initials": "A"}, {"family": "Gauba", "given": "Krishan", "initials": "K"}, {"family": "Goyal", "given": "Kapil", "initials": "K"}, {"family": "Singh", "given": "Mini P", "initials": "MP"}, {"family": "Ghosh", "given": "Arnab", "initials": "A"}, {"family": "Kajal", "given": "Kamal", "initials": "K"}, {"family": "Mahajan", "given": "Varun", "initials": "V"}, {"family": "Suri", "given": "Vikas", "initials": "V"}, {"family": "Bhalla", "given": "Ashish", "initials": "A"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Clin Exp Dent Res", "issn": "2057-4347", "volume": "8", "issue": "4", "pages": "988-1001", "issn-l": null}, "abstract": "The aim of this study was to validate an active matrix metalloproteinase (MMP-8) point-of-care diagnostic tool in COVID-19 patients with periodontal disease.\n\nSeventy-two COVID-19-positive and 30 COVID-19-negative subjects were enrolled in the study. Demographic data were recorded, periodontal examination carried out, and chairside tests run for evaluating the expression of active MMP-8 (aMMP-8) in the site with maximum periodontal breakdown via gingival crevicular fluid sampling as well as via a mouth rinse-based kit for general disease activity. In COVID-19-positive patients, the kits were run again once the patients turned COVID-19 negative.\n\nThe overall (n = 102) sensitivity/specificity of the mouthrinse-based kits to detect periodontal disease was 79.41%/36.76% and that of site-specific kits was 64.71%/55.88% while adjusting for age, gender, and smoking status increased the sensitivity and specificity (82.35%/76.47% and 73.53%/88.24, respectively). Receiver operating characteristic (ROC) analysis for the adjusted model revealed very good area under the ROC curve 0.746-0.869 (p < .001) and 0.740-0.872 (p < .001) (the aMMP-8 mouth rinse and site-specific kits, respectively). No statistically significant difference was observed in the distribution of results of aMMP-8 mouth rinse test (p = .302) and aMMP-8 site-specific test (p = .189) once the subjects recovered from COVID-19.\n\nThe findings of the present study support the aMMP-8 point-of-care testing (PoCT) kits as screening tools for periodontitis in COVID-19 patients. The overall screening accuracy can be further increased by utilizing adjunctively risk factors of periodontitis. The reported noninvasive, user-friendly, and objective PoCT diagnostic methodology may provide a way of stratifying risk groups, deciding upon referrals, and in the institution of diligent oral hygiene regimens.", "doi": "10.1002/cre2.589", "pmid": "35818743", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9350191"}], "notes": [], "created": "2022-08-17T10:38:13.639Z", "modified": "2022-08-17T10:38:13.684Z"}, {"entity": "publication", "iuid": "d1eb92db423247949c9d1e0866bfded6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1eb92db423247949c9d1e0866bfded6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1eb92db423247949c9d1e0866bfded6"}}, "title": "SARS-COV-2 a trigger of myelin oligodendrocyte glycoprotein-associated disorder.", "authors": [{"family": "Johnsson", "given": "Magnus", "initials": "M", "orcid": "0000-0001-7151-201X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6bef027f84b48efa6d645d3ce116414.json"}}, {"family": "Asztely", "given": "Fredrik", "initials": "F"}, {"family": "Hejnebo", "given": "Susanne", "initials": "S"}, {"family": "Axelsson", "given": "Markus", "initials": "M"}, {"family": "Malmestr\u00f6m", "given": "Clas", "initials": "C", "orcid": "0000-0003-2477-0088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1de3045467364de388c62f23a8a4e171.json"}}, {"family": "Olausson", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Lycke", "given": "Jan", "initials": "J", "orcid": "0000-0002-7891-8466", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/95ab980b7e15438f94f49826d1c4487a.json"}}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Ann Clin Transl Neurol", "issn": "2328-9503", "volume": "9", "issue": "8", "pages": "1296-1301", "issn-l": "2328-9503"}, "abstract": "SARS-COV-2 frequently cause neurological disorders and is sometimes associated with onset of autoimmune diseases affecting the nervous system. Over recent years, a rare but distinct diagnosis designated myelin oligodendrocyte glycoprotein-associated disorder (MOGAD) has been recognized in patients with attacks of optic neuritis, myelitis, or encephalomyelitis and increased levels of anti-MOG antibodies. The cause of MOGAD is unknown. However, there have been reports of single cases of MOGAD in patients with Covid-19 infection. We report a series of SARS-CoV-2 positive patients that developed MOGAD, but a homology search did not support a cross-reactive immune response to SARS-CoV-2 spike-protein and MOG.", "doi": "10.1002/acn3.51609", "pmid": "35713508", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9349599"}], "notes": [], "created": "2022-06-20T18:05:43.774Z", "modified": "2022-08-17T12:46:46.703Z"}, {"entity": "publication", "iuid": "2805ba660c7c40539470a6f03e67b32d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2805ba660c7c40539470a6f03e67b32d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2805ba660c7c40539470a6f03e67b32d"}}, "title": "Risk factors for multisystem inflammatory syndrome in children - A population-based cohort study of over 2 million children.", "authors": [{"family": "Rhedin", "given": "Samuel", "initials": "S"}, {"family": "Lundholm", "given": "Cecilia", "initials": "C"}, {"family": "Horne", "given": "AnnaCarin", "initials": "A"}, {"family": "Smew", "given": "Awad I", "initials": "AI"}, {"family": "Osvald", "given": "Emma Caffrey", "initials": "EC"}, {"family": "Haddadi", "given": "Araz", "initials": "A"}, {"family": "Alfv\u00e9n", "given": "Tobias", "initials": "T"}, {"family": "Kahn", "given": "Robin", "initials": "R"}, {"family": "Kr\u00f3l", "given": "Petra", "initials": "P"}, {"family": "Swedish Pediatric MIS-C Consortium", "given": "", "initials": ""}, {"family": "Brew", "given": "Bronwyn Haasdyk", "initials": "BH"}, {"family": "Almqvist", "given": "Catarina", "initials": "C"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "19", "pages": "100443", "issn-l": null}, "abstract": "Although severe acute COVID-19 is rare in children, SARS-CoV-2 infection can trigger the novel post-infectious condition multisystem inflammatory syndrome in children (MIS-C). Increased knowledge on risk factors for MIS-C could improve our understanding of the pathogenesis of the condition and better guide targeted public health interventions. The aim of the study was to assess risk factors for MIS-C with the aim to identify vulnerable children.\n\nA register-based cohort study including all children and adolescents <19 years born in Sweden between March 1, 2001- December 31, 2020 was performed. Data on sociodemographic risk factors and comorbidities (sex, age, parental region of birth, parental education, asthma, autoimmune disease, chromosomal anomalies, chronic heart disease, chronic lung disease, obesity, life-limiting condition) were retrieved from national health and population registers. The outcome was MIS-C diagnosis according to the Swedish Pediatric Rheumatology Quality Register during March 1, 2020 - December 8, 2021.Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox regression analysis. Incidence rates per 100 000 person-years were calculated assuming a Poisson distribution.\n\nAmong 2 117 443 children included in the study, 253 children developed MIS-C, corresponding to an incidence rate of 6\u00b78 (95% CI: 6\u00b70-7\u00b76) per 100 000 person-years. Male sex (HR 1\u00b765, 95% CI: 1\u00b728-2\u00b714), age 5-11 years (adjusted HR 1\u00b744, 95% CI: 1\u00b706-1\u00b795 using children 0-4 years as reference), foreign-born parents (HR 2\u00b753, 95% CI: 1\u00b793-3\u00b734), asthma (aHR 1\u00b749, 95% CI: 1\u00b700-2\u00b720), obesity (aHR 2\u00b715, 95% CI: 1\u00b709-4\u00b725) and life-limiting conditions (aHR 3\u00b710, 95% CI: 1\u00b780-5\u00b733) were associated with MIS-C. Children 16-18 years had a reduced risk for MIS-C (aHR 0\u00b745, 95% CI: 0\u00b724-0\u00b785).\n\nWe report increased risks for MIS-C in children with male sex, age 5-11 years, foreign-born parents, asthma, obesity, and life-limiting condition. Knowing these risk populations might facilitate identification of children with MIS-C and potentially guide targeted public health interventions. Nevertheless, the absolute risks for MIS-C were very low.\n\nFinancial support was provided from the Swedish Research Council (grant no 2018-02640), the Swedish Heart-Lung Foundation (grant no 20210416), the Asthma and Allergy Association, Ake Wiberg foundation, the Samariten Foundation, the Society of Child Care, and Region Stockholm.", "doi": "10.1016/j.lanepe.2022.100443", "pmid": "35945929", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(22)00137-5"}, {"db": "pmc", "key": "PMC9353212"}], "notes": [], "created": "2022-08-11T11:49:13.500Z", "modified": "2022-08-11T11:49:13.513Z"}, {"entity": "publication", "iuid": "00a60a53400d4140af4f0c1811e60055", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/00a60a53400d4140af4f0c1811e60055.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/00a60a53400d4140af4f0c1811e60055"}}, "title": "Public health, surveillance policies and actions to prevent community spread of COVID-19 in Denmark, Serbia and Sweden.", "authors": [{"family": "Andersen", "given": "Pernille Tanggaard", "initials": "PT", "orcid": "0000-0001-7334-761X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7af3f08a7c14f0f957525c519bd228f.json"}}, {"family": "Loncarevic", "given": "Natasa", "initials": "N"}, {"family": "Damgaard", "given": "Maria Busk", "initials": "MB"}, {"family": "Jacobsen", "given": "Mette Winge", "initials": "MW"}, {"family": "Bassioni-Stamenic", "given": "Farida", "initials": "F"}, {"family": "Eklund Karlsson", "given": "Leena", "initials": "L", "orcid": "0000-0003-2052-0989", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8ef669769e44be2abff29ee81474c49.json"}}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "711-729", "volume": "50", "issue": "6", "issn-l": "1403-4948"}, "abstract": "Aim: This study investigates the non-medical public health and surveillance policies and actions for tackling the community spread of COVID-19 pandemic in Denmark, Serbia and Sweden during the first five months of the pandemic in 2020. Method: The study is inspired by a process-tracing design for case study with a focus on the non-medical measures and surveillance strategies implemented by the three countries. The comprehensive collection and study of national documents formed the basis of the document analysis. Results: The Danish strategy was to prolong the transmission period, preventing high numbers of infected cases from impacting their healthcare capacity. The government's strategy was characterized by strict governance elements, health guidelines and behavioural recommendations. In Serbia, the main strategy was to prevent the spread and control of the infectious disease by shifting all human and material resources towards the function of controlling the spread. Serbia applied the strictest measures in the fight against coronavirus in relation to other countries in the region and in Europe. The Swedish strategy focused more on recommendations than requirements to motivate the public to modify their behaviours voluntarily. Sweden's loose pandemic strategy implementation focused on voluntary and stepwise action rather than legislation and compulsory measures. Conclusions:The public health policies and actions implemented to prevent community spread of COVID-19 in Denmark, Serbia and Sweden varied during the first five months of the pandemic. The differences in their response were due to delays in implementation, inconsistencies in perspectives towards the outbreak and the capacity of each country in terms of their pandemic preparedness and response.", "doi": "10.1177/14034948211056215", "pmid": "34844483", "labels": {"Type: Review": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T18:10:53.356Z", "modified": "2023-01-13T14:46:19.134Z"}, {"entity": "publication", "iuid": "43eb008807304184af3e179e29e7898e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/43eb008807304184af3e179e29e7898e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/43eb008807304184af3e179e29e7898e"}}, "title": "Outcome of infection with omicron SARS-CoV-2 variant in patients with hematological malignancies: An EPICOVIDEHA survey report.", "authors": [{"family": "Blennow", "given": "Ola", "initials": "O", "orcid": "0000-0002-7167-7882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2318c3973e66443aa14fceca0908d127.json"}}, {"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J", "orcid": "0000-0002-6766-8297", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dea501020d2042ad83d1b024987792f4.json"}}, {"family": "Nowak", "given": "Piotr", "initials": "P", "orcid": "0000-0003-2747-0734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1d81fdccf9e424fa99ea5227b031843.json"}}, {"family": "Itri", "given": "Federico", "initials": "F", "orcid": "0000-0002-3532-5281", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98feda63fd134739ab222629acdc3e46.json"}}, {"family": "Van Doesum", "given": "Jaap", "initials": "J", "orcid": "0000-0003-0214-3219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49152311cb004139904554d1c096c05c.json"}}, {"family": "L\u00f3pez-Garc\u00eda", "given": "Alberto", "initials": "A", "orcid": "0000-0002-5354-5261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c785356a67e4cbb9835fe9ce04a6153.json"}}, {"family": "Farina", "given": "Francesca", "initials": "F", "orcid": "0000-0002-5124-6970", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06ead8985bd241ee814a94a6186bb898.json"}}, {"family": "Jaksic", "given": "Ozren", "initials": "O", "orcid": "0000-0003-4026-285X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/359a2798d30a4a5aa03f587bfb87322f.json"}}, {"family": "Pincz\u00e9s", "given": "L\u00e1szl\u00f3 Imre", "initials": "LI", "orcid": "0000-0003-0453-1709", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed1924c856a44492a74f02654b53ca61.json"}}, {"family": "Bilgin", "given": "Yavuz M", "initials": "YM", "orcid": "0000-0002-3783-3407", "researcher": {"href": 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"Rebeca", "initials": "R", "orcid": "0000-0003-2838-1776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d185c2be2bd4d8b9929a1812ae9d327.json"}}, {"family": "Hoenigl", "given": "Martin", "initials": "M", "orcid": "0000-0002-1653-2824", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f06a81d02454972bb9b64fea7c14dd4.json"}}, {"family": "Dragonetti", "given": "Giulia", "initials": "G", "orcid": "0000-0003-1775-6333", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81694822ac4d4074bfabe757d03f5f9e.json"}}, {"family": "Chai", "given": "Louis Yi Ann", "initials": "LYA"}, {"family": "Kho", "given": "Chi Shan", "initials": "CS"}, {"family": "Bonanni", "given": "Matteo", "initials": "M"}, {"family": "Li\u00e9vin", "given": "Rapha\u00ebl", "initials": "R", "orcid": "0000-0002-5097-591X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d190434cf5f428f9714a761a1b67889.json"}}, {"family": "Marchesi", "given": "Francesco", "initials": "F", "orcid": "0000-0001-6353-2272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e09d8d1e4eb498781444b8d095687a0.json"}}, {"family": "Cornely", "given": "Oliver A", "initials": "OA", "orcid": "0000-0001-9599-3137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3c62d8346924e69b6c99e4007c3831c.json"}}, {"family": "Pagano", "given": "Livio", "initials": "L", "orcid": "0000-0001-8287-928X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbf92a9779614910aeafcc6c21d880e2.json"}}], "type": "letter", "published": "2022-08-00", "journal": {"title": "Am J Hematol", "issn": "0361-8609", "issn-l": null, "volume": "97", "issue": "8", "pages": "E312-E317"}, "abstract": null, "doi": "10.1002/ajh.26626", "pmid": "35702878", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9349555"}], "notes": [], "created": "2022-06-20T18:12:52.201Z", "modified": "2022-08-17T13:00:29.008Z"}, {"entity": "publication", "iuid": "419c229086fc4e749e9c98b961bac8fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/419c229086fc4e749e9c98b961bac8fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/419c229086fc4e749e9c98b961bac8fc"}}, "title": "Monoclonal antibodies binding data for SARS-CoV-2 proteins.", "authors": [{"family": "Mishra", "given": "Nawneet", "initials": "N"}, {"family": "Teyra", "given": "Joan", "initials": "J"}, {"family": "Boytz", "given": "RuthMabel", "initials": "R"}, {"family": "Miersch", "given": "Shane", "initials": "S"}, {"family": "Merritt", "given": "Trudy N", "initials": "TN"}, {"family": "Cardarelli", "given": "Lia", "initials": "L"}, {"family": "Gorelik", "given": "Maryna", "initials": "M"}, {"family": "Mihalic", "given": "Filip", "initials": "F"}, {"family": "Jemth", "given": "Per", "initials": "P"}, {"family": "Davey", "given": "Robert A", "initials": "RA"}, {"family": "Sidhu", "given": "Sachdev S", "initials": "SS"}, {"family": "Leung", "given": "Daisy W", "initials": "DW"}, {"family": "Amarasinghe", "given": "Gaya K", "initials": "GK"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Data Brief", "issn": "2352-3409", "volume": "43", "pages": "108415", "issn-l": null}, "abstract": "SARS-CoV-2 pandemic opens up the curiosity of understanding the coronavirus. This demand for the development of the regent, which can be used for academic and therapeutic applications. The present data provide the biochemical characterization of synthetically developed monoclonal antibodies for the SARS-CoV-2 proteins. The antibodies from phage-displayed antibody libraries were selected with the SARS-CoV-2 proteins immobilized in microwell plates. The clones which bind to the antigen in Fab-phage ELISA were selected, and a two-point competitive phage ELISA was performed. Antibodies binding kinetic of IgGs for SARS-CoV2 proteins further carried with B.L.I. Systematic analysis of binding with different control proteins and purified SARS-CoV-2 ensured the robustness of the antibodies.", "doi": "10.1016/j.dib.2022.108415", "pmid": "35789908", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9232259"}, {"db": "pii", "key": "S2352-3409(22)00612-6"}], "notes": [], "created": "2022-08-17T13:08:36.040Z", "modified": "2023-06-19T15:05:48.083Z"}, {"entity": "publication", "iuid": "b8e48b55409345ff8cabbd0a928ab919", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8e48b55409345ff8cabbd0a928ab919.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8e48b55409345ff8cabbd0a928ab919"}}, "title": "Milder disease trajectory among COVID-19 patients hospitalised with the SARS-CoV-2 Omicron variant compared with the Delta variant in Norway.", "authors": [{"family": "St\u00e5lcrantz", "given": "Jeanette", "initials": "J", "orcid": "0000-0001-8086-4244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e6220d843754651b919cae3e687d3d5.json"}}, {"family": "Kristoffersen", "given": "Anja Br\u00e5then", "initials": "AB"}, {"family": "B\u00f8\u00e5s", "given": "H\u00e5kon", "initials": "H", "orcid": "0000-0002-5917-1563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9cc00f104cd64e53ab58eebd46368861.json"}}, {"family": "Veneti", "given": "Lamprini", "initials": "L"}, {"family": "Sepp\u00e4l\u00e4", "given": "Elina", "initials": "E"}, {"family": "Aasand", "given": "Nina", "initials": "N"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "Kv\u00e5le", "given": "Reidar", "initials": "R"}, {"family": "Bragstad", "given": "Karoline", "initials": "K"}, {"family": "Buanes", "given": "Eirik Alnes", "initials": "EA"}, {"family": "Whittaker", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "volume": "50", "issue": "6", "pages": "676-682", "issn-l": "1403-4948"}, "abstract": "Using individual-level national registry data, we conducted a cohort study to estimate differences in the length of hospital stay, and risk of admission to an intensive care unit and in-hospital death among patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant, compared with patients infected with Delta variant in Norway. We included 409 (38%) patients infected with Omicron and 666 (62%) infected with Delta who were hospitalised with coronavirus disease 2019 (COVID-19) as the main cause of hospitalisation between 6 December 2021 and 6 February 2022. Omicron patients had a 48% lower risk of intensive care admission (adjusted hazard ratios (aHR): 0.52, 95% confidence interval (CI): 0.34-0.80) and a 56% lower risk of in-hospital death (aHR: 0.44, 95%CI: 0.24-0.79) compared with Delta patients. Omicron patients had a shorter length of stay (with or without ICU stay) compared with Delta patients in the age groups from 18 to 79 years and those who had at least completed their primary vaccination. This supports growing evidence of reduced disease severity among hospitalised Omicron patients compared with Delta patients.", "doi": "10.1177/14034948221108548", "pmid": "35799474", "labels": {"Category: Omicron VoC": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-17T10:45:15.917Z", "modified": "2022-08-17T10:45:16.004Z"}, {"entity": "publication", "iuid": "d2cf9578d52c495ca762c0a8332d614c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d2cf9578d52c495ca762c0a8332d614c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d2cf9578d52c495ca762c0a8332d614c"}}, "title": "Lessons from the IMPAACT of coronavirus disease 2019 public health restrictions on food allergy-associated anxiety.", "authors": [{"family": "Golding", "given": "Michael A", "initials": "MA"}, {"family": "Protudjer", "given": "Jennifer L P", "initials": "JLP"}], "type": "editorial", "published": "2022-08-00", "journal": {"title": "Ann Allergy Asthma Immunol", "issn": "1534-4436", "volume": "129", "issue": "2", "pages": "134-135", "issn-l": null}, "abstract": null, "doi": "10.1016/j.anai.2022.05.018", "pmid": "35878957", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1081-1206(22)00450-1"}], "notes": [], "created": "2022-08-12T08:39:02.556Z", "modified": "2022-08-12T08:39:02.586Z"}, {"entity": "publication", "iuid": "1c6630c4d7dc433d982ba605747c9041", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1c6630c4d7dc433d982ba605747c9041.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1c6630c4d7dc433d982ba605747c9041"}}, "title": "Income differences in COVID-19 incidence and severity in Finland among people with foreign and native background: A population-based cohort study of individuals nested within households.", "authors": [{"family": "Saarinen", "given": "Sanni", "initials": "S", "orcid": "0000-0002-4866-002X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/311a9e98129c432782f7e893757c60a1.json"}}, {"family": "Moustgaard", "given": "Heta", "initials": "H"}, {"family": "Remes", "given": "Hanna", "initials": "H", "orcid": "0000-0002-9291-703X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cbdeb824ba154b5595275b2275e32568.json"}}, {"family": "Sallinen", "given": "Riikka", "initials": "R"}, {"family": "Martikainen", "given": "Pekka", "initials": "P", "orcid": "0000-0001-9374-1438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc740067d77b4773826c66c9eddc6827.json"}}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "PLoS Med", "issn": "1549-1676", "volume": "19", "issue": "8", "pages": "e1004038", "issn-l": "1549-1277"}, "abstract": "Although intrahousehold transmission is a key source of Coronavirus Disease 2019 (COVID-19) infections, studies to date have not analysed socioeconomic risk factors on the household level or household clustering of severe COVID-19. We quantify household income differences and household clustering of COVID-19 incidence and severity.\n\nWe used register-based cohort data with individual-level linkage across various administrative registers for the total Finnish population living in working-age private households (N = 4,315,342). Incident COVID-19 cases (N = 38,467) were identified from the National Infectious Diseases Register from 1 July 2020 to 22 February 2021. Severe cases (N = 625) were defined as having at least 3 consecutive days of inpatient care with a COVID-19 diagnosis and identified from the Care Register for Health Care between 1 July 2020 and 31 December 2020. We used 2-level logistic regression with individuals nested within households to estimate COVID-19 incidence and case severity among those infected. Adjusted for age, sex, and regional characteristics, the incidence of COVID-19 was higher (odds ratio [OR] 1.67, 95% CI 1.58 to 1.77, p < 0.001, 28.4% of infections) among individuals in the lowest household income quintile than among those in the highest quintile (18.9%). The difference attenuated (OR 1.23, 1.16 to 1.30, p < 0.001) when controlling for foreign background but not when controlling for other household-level risk factors. In fact, we found a clear income gradient in incidence only among people with foreign background but none among those with native background. The odds of severe illness among those infected were also higher in the lowest income quintile (OR 1.97, 1.52 to 2.56, p < 0.001, 28.0% versus 21.6% in the highest quintile), but this difference was fully attenuated (OR 1.08, 0.77 to 1.52, p = 0.64) when controlling for other individual-level risk factors-comorbidities, occupational status, and foreign background. Both incidence and severity were strongly clustered within households: Around 77% of the variation in incidence and 20% in severity were attributable to differences between households. The main limitation of our study was that the test uptake for COVID-19 may have differed between population subgroups.\n\nLow household income appears to be a strong risk factor for both COVID-19 incidence and case severity, but the income differences are largely driven by having foreign background. The strong household clustering of incidence and severity highlights the importance of household context in the prevention and mitigation of COVID-19 outcomes.", "doi": "10.1371/journal.pmed.1004038", "pmid": "35947575", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PMEDICINE-D-21-04207"}], "notes": [], "created": "2022-08-11T11:47:22.362Z", "modified": "2022-08-12T08:30:09.536Z"}, {"entity": "publication", "iuid": "eb25df38bf974d95a90185675f983989", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb25df38bf974d95a90185675f983989.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb25df38bf974d95a90185675f983989"}}, "title": "Health care utilization and outcomes in older adults after Traumatic Brain Injury: A CENTER-TBI study.", "authors": [{"family": "van der Vlegel", "given": "Marjolein", "initials": "M"}, {"family": "Mikoli\u0107", "given": "Ana", "initials": "A"}, {"family": "Lee Hee", "given": "Quentin", "initials": "Q"}, {"family": "Kaplan", "given": "Z L Rana", "initials": "ZLR"}, {"family": "Retel Helmrich", "given": "Isabel R A", "initials": "IRA"}, {"family": "van Veen", "given": "Ernest", "initials": "E"}, {"family": "Andelic", "given": "Nada", "initials": "N"}, {"family": "Steinbuechel", "given": "Nicole V", "initials": "NV"}, {"family": "Plass", "given": "Anne Marie", "initials": "AM"}, {"family": "Zeldovich", "given": "Marina", "initials": "M"}, {"family": "Wilson", "given": "Lindsay", "initials": "L"}, {"family": "Maas", "given": "Andrew I R", "initials": "AIR"}, {"family": "Haagsma", "given": "Juanita A", "initials": "JA"}, {"family": "Polinder", "given": "Suzanne", "initials": "S"}, {"family": "CENTER-TBI Participants and Investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Injury", "issn": "1879-0267", "volume": "53", "issue": "8", "pages": "2774-2782", "issn-l": null}, "abstract": "The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged \u226565 years, forming a growing public health problem. However, older adults are underrepresented in TBI research. Therefore, we aimed to provide an overview of health-care utilization, and of six-month outcomes after TBI and their determinants in older adults who sustained a TBI.\n\nWe used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. In-hospital and post-hospital health care utilization and outcomes were described for patients aged \u226565 years. Ordinal and linear regression analyses were performed to identify determinants of the Glasgow Outcome Scale Extended (GOSE), health-related quality of life (HRQoL), and mental health symptoms six-months post-injury.\n\nOf 1254 older patients, 45% were admitted to an ICU with a mean length of stay of 9 days. Nearly 30% of the patients received inpatient rehabilitation. In total, 554/1254 older patients completed the six-month follow-up questionnaires. The mortality rate was 9% after mild and 60% after moderate/severe TBI, and full recovery based on GOSE was reported for 44% of patients after mild and 6% after moderate/severe TBI. Higher age and increased injury severity were primarily associated with functional impairment, while pre-injury systemic disease, psychiatric conditions and lower educational level were associated with functional impairment, lower generic and disease-specific HRQoL and mental health symptoms.\n\nThe rate of impairment and disability following TBI in older adults is substantial, and poorer outcomes across domains are associated with worse preinjury health. Nonetheless, a considerable number of patients fully or partially returns to their preinjury functioning. There should not be pessimism about outcomes in older adults who survive.", "doi": "10.1016/j.injury.2022.05.009", "pmid": "35725508", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0020-1383(22)00329-1"}], "notes": [], "created": "2022-08-17T13:04:27.837Z", "modified": "2022-08-17T13:04:27.864Z"}, {"entity": "publication", "iuid": "4a20c42bea8642c68d665eda819b9577", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4a20c42bea8642c68d665eda819b9577.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4a20c42bea8642c68d665eda819b9577"}}, "title": "Gaming and social media use among adolescents in the midst of the COVID-19 pandemic.", "authors": [{"family": "Nilsson", "given": "Anders", "initials": "A", "orcid": "0000-0002-0982-8483", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aaa310c68f1a475380fe60327e00405f.json"}}, {"family": "Rosendahl", "given": "Ingvar", "initials": "I", "orcid": "0000-0002-1325-913X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bbfd62b47d64bf1909cdc79d6d85054.json"}}, {"family": "Jayaram-Lindstr\u00f6m", "given": "Nitya", "initials": "N"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Nordisk Alkohol Nark", "issn": "1458-6126", "volume": "39", "issue": "4", "pages": "347-361", "issn-l": null}, "abstract": "Background and aims: The COVID-19 pandemic has dramatically changed life circumstances for adolescents worldwide. With schools being closed and regular activities being cancelled, gaming and social media use are activities that might gain in importance. There is a risk that these online behaviours have negative effects on other important activities, such as being physically active, sleeping, and studying, as well as general well-being. The aim of this study was to investigate the effects of the COVID-19 pandemic on gaming and social media use, and its effects on the well-being of adolescents. Methods: A total of 1232 adolescents (82.5% female) participated in an anonymous web survey containing questions on gaming, social media use, and perceived negative consequences of gaming and social media use during the COVID-19 pandemic. The results were analysed with a quasi-Poisson regression model. Results: The results indicated an increase in gaming and social media use, which was associated with negative consequences and perceived well-being. A majority of adolescents reported that they used social media more than they felt comfortable with. There were large differences between boys and girls, with girls being more negatively affected across measures. Discussion: The increase in gaming and social media use during the COVID-19 pandemic might have negative effects on the well-being of adolescents, and on other activities that are important to health. Our interpretation of the findings is that gaming and social media use might partly function as coping mechanisms to deal with stress and/or boredom resulting from COVID-19 restrictions. There is a risk that these coping strategies become maladaptive over time. Conclusions: The restrictions from the COVID-19 pandemic have resulted in an increase in the amount of time adolescents spend gaming and on social media, which might have negative effects on their well-being. This study highlights the urgent need to consider adaptive and healthy coping strategies for adolescents given the pandemic may mean that daily living could continue to be altered in the near future.", "doi": "10.1177/14550725221074997", "pmid": "35999947", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1177_14550725221074997"}, {"db": "pmc", "key": "PMC8819558"}], "notes": [], "created": "2022-08-26T04:44:06.685Z", "modified": "2022-08-26T04:44:06.799Z"}, {"entity": "publication", "iuid": "c43b69e1fdf14da28e0eb4ba5b79d1a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c43b69e1fdf14da28e0eb4ba5b79d1a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c43b69e1fdf14da28e0eb4ba5b79d1a4"}}, "title": "Epigenetic mechanisms regulate sex-specific bias in disease manifestations.", "authors": [{"family": "Chlamydas", "given": "Sarantis", "initials": "S"}, {"family": "Markouli", "given": "Mariam", "initials": "M"}, {"family": "Strepkos", "given": "Dimitrios", "initials": "D"}, {"family": "Piperi", "given": "Christina", "initials": "C", "orcid": "0000-0002-2701-0618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15e4ce9ec9754a6b881eaaa8d1de3c17.json"}}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "J Mol Med (Berl)", "issn": "1432-1440", "volume": "100", "issue": "8", "pages": "1111-1123", "issn-l": null}, "abstract": "Sex presents a vital determinant of a person's physiology, anatomy, and development. Recent clinical studies indicate that sex is also involved in the differential manifestation of various diseases, affecting both clinical outcome as well as response to therapy. Genetic and epigenetic changes are implicated in sex bias and regulate disease onset, including the inactivation of the X chromosome as well as sex chromosome aneuploidy. The differential expression of X-linked genes, along with the presence of sex-specific hormones, exhibits a significant impact on immune system function. Several studies have revealed differences between the two sexes in response to infections, including respiratory diseases and COVID-19 infection, autoimmune disorders, liver fibrosis, neuropsychiatric diseases, and cancer susceptibility, which can be explained by sex-biased immune responses. In the present review, we explore the input of genetic and epigenetic interplay in the sex bias underlying disease manifestation and discuss their effects along with sex hormones on disease development and progression, aiming to reveal potential new therapeutic targets. KEY MESSAGES: Sex is involved in the differential manifestation of various diseases. Epigenetic modifications influence X-linked gene expression, affecting immune response to infections, including COVID-19. Epigenetic mechanisms are responsible for the sex bias observed in several respiratory and autoimmune disorders, liver fibrosis, neuropsychiatric diseases, and cancer.", "doi": "10.1007/s00109-022-02227-x", "pmid": "35764820", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00109-022-02227-x"}, {"db": "pmc", "key": "PMC9244100"}], "notes": [], "created": "2022-08-19T05:34:12.520Z", "modified": "2022-08-19T05:34:22.233Z"}, {"entity": "publication", "iuid": "c3deb4b2a368402997300e196e67df11", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3deb4b2a368402997300e196e67df11.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3deb4b2a368402997300e196e67df11"}}, "title": "Corrigendum. Re: de Sousa, N.R., et al., 2022. Detection and isolation of airborne SARS-CoV-2 in a hospital setting. Indoor air, 32(3), e13023.", "authors": [{"family": "Rufino de Sousa", "given": "Nuno", "initials": "N", "orcid": "0000-0002-0670-9788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1cb037a9e7f44a489dd84d6f5ba513d7.json"}}, {"family": "Steponaviciute", "given": "Laura", "initials": "L"}, {"family": "Margerie", "given": "Lucille", "initials": "L", "orcid": "0000-0001-9537-1231", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e7015e5251242ecb70df112f997182b.json"}}, {"family": "Nissen", "given": "Karolina", "initials": "K"}, {"family": "Kjellin", "given": "Midori", "initials": "M", "orcid": "0000-0002-1377-6014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cbf761ec44641a5a70ee1b8f7964a20.json"}}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Salaneck", "given": "Erik", "initials": "E"}, {"family": "Udekwu", "given": "Klas I", "initials": "KI"}, {"family": "Rothfuchs", "given": "Antonio Gigliotti", "initials": "AG", "orcid": "0000-0001-6001-7240", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00102c49ae2d41828272e850cd551c9f.json"}}], "type": "letter", "published": "2022-08-00", "journal": {"title": "Indoor Air", "issn": "0905-6947", "volume": "32", "issue": "8", "pages": "e13085", "issn-l": null}, "abstract": null, "doi": "10.1111/ina.13085", "pmid": "36040276", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-10-07T12:50:16.510Z", "modified": "2022-10-07T12:51:48.911Z"}, {"entity": "publication", "iuid": "e7c6cac338774bdd8fc521b6eaadba9b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e7c6cac338774bdd8fc521b6eaadba9b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e7c6cac338774bdd8fc521b6eaadba9b"}}, "title": "Changes in mortality trends amongst common diseases during the COVID-19 pandemic in Sweden.", "authors": [{"family": "Axenhus", "given": "Michael", "initials": "M", "orcid": "0000-0002-2476-4465", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c8ec5de3a68400981b1caa3e5260828.json"}}, {"family": "Schedin-Weiss", "given": "Sophia", "initials": "S"}, {"family": "Winblad", "given": "Bengt", "initials": "B"}, {"family": "Wimo", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "748-755", "volume": "50", "issue": "6", "issn-l": "1403-4948"}, "abstract": "It has been found that COVID-19 increases deaths within common diseases in countries that have implemented strict lockdowns. In order to elucidate the proper national response to a pandemic, the mortality rates within COVID-19 and various diseases need to be studied in countries whose pandemic response differ. Sweden represents a country with lax pandemic restrictions, and we aimed to study the effects of COVID-19 on historical mortality rates within common diseases during 2020.\n\nRegression models and moving averages were used to predict expected premature mortality per the ICD-10 during 2020 using historical data sets. Predicted values were then compared to recorded premature mortality to identify changes in mortality trends.\n\nSeasonal increased mortality was found within neurological diseases. Infectious diseases, tumours and cardiac disease mortality rates decreased compared to expected outcome.\n\nChanges in mortality trends were observed for several common diseases during the COVID-19 pandemic. Neurological and cardiac conditions, infections and tumours are examples of diseases that were heavily affected by the pandemic. The indirect effects of COVID-19 on certain patient populations should be considered when determining pandemic impact.", "doi": "10.1177/14034948211064656", "pmid": "34933630", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9361422"}], "notes": [], "created": "2022-01-03T15:31:10.078Z", "modified": "2023-01-13T13:36:55.994Z"}, {"entity": "publication", "iuid": "0a372b79beb64fd8a99d8cb5ca649254", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a372b79beb64fd8a99d8cb5ca649254.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a372b79beb64fd8a99d8cb5ca649254"}}, "title": "COVID-19 vaccine hesitancy in Sweden and Italy: The role of trust in authorities.", "authors": [{"family": "Raffetti", "given": "Elena", "initials": "E", "orcid": "0000-0001-8742-3986", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49139fd67cc4feb9e68942e70eecd92.json"}}, {"family": "Mondino", "given": "Elena", "initials": "E"}, {"family": "Di Baldassarre", "given": "Giuliano", "initials": "G"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "803-809", "volume": "50", "issue": "6", "issn-l": "1403-4948"}, "abstract": "The success of vaccination campaigns against COVID-19 infection is vital for moving from a COVID-19 pandemic to an endemic scenario. We aimed to unravel the influence of the risk perception of epidemics along with individual and contextual factors on adherence to COVID-19 vaccination campaigns in Italy and Sweden.\n\nWe compared the results of two nationwide surveys carried out in August 2021 across four domains of epidemic risk perception: perceived likelihood, perceived impact on the individual and perceived individual and authority knowledge. The roles of individual and contextual determinants were also explored.\n\nThe survey included 2144 participants in Sweden (52.3% women) and 2010 in Italy (52.6% women). In both countries, we found that trust in authorities was one of the main drivers of this process, with two-fold increased odds of being vaccinated. Being highly educated and having a higher relative income were associated with a higher adherence to the vaccination campaign (for relative income OR = 1.44, 95% CI 1.23-1.67 in Sweden and OR = 1.18, 95% CI 1.04-1.34 in Italy; for education OR = 1.90, 95% CI 1.30-2.77 in Sweden and OR = 1.47, 95% CI 1.09-1.97 in Italy), whereas a right and centre-right compared with a left and centre-left political orientation was negatively related to vaccination adherence (OR = 0.41, 95% CI 0.25-0.67 in Sweden and OR = 0.47, 95% CI 0.33-0.68 in Italy).\n\nIncreasing trust in authorities, along with an equal global distribution of vaccine doses, can contribute to accelerating vaccination campaigns around the world and, in turn, to move towards an endemic scenario.", "doi": "10.1177/14034948221099410", "pmid": "35656576", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9361415"}], "notes": [], "created": "2022-06-21T17:19:26.872Z", "modified": "2023-01-13T13:26:46.332Z"}, {"entity": "publication", "iuid": "2d8688815a6f4c68bbb3feddac31eff3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d8688815a6f4c68bbb3feddac31eff3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d8688815a6f4c68bbb3feddac31eff3"}}, "title": "COVID vaccination in older adults.", "authors": [{"family": "H\u00e4gg", "given": "Sara", "initials": "S", "orcid": "0000-0002-2452-1500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f65e8028f3a0410099f7dfdbfa79ca42.json"}}, {"family": "Religa", "given": "Dorota", "initials": "D"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Nat Microbiol", "issn": "2058-5276", "volume": "7", "issue": "8", "pages": "1106-1107", "issn-l": null}, "abstract": null, "doi": "10.1038/s41564-022-01166-0", "pmid": "35836001", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41564-022-01166-0"}], "notes": [], "created": "2022-08-12T09:00:47.401Z", "modified": "2022-08-12T09:00:47.457Z"}, {"entity": "publication", "iuid": "9708437ef73e44eda9a26129ec65469d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9708437ef73e44eda9a26129ec65469d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9708437ef73e44eda9a26129ec65469d"}}, "title": "Autoantibodies in COVID-19 correlate with antiviral humoral responses and distinct immune signatures.", "authors": [{"family": "Taeschler", "given": "Patrick", "initials": "P", "orcid": "0000-0003-0522-7629", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b070a1c2cd840849b9e8ce333068867.json"}}, {"family": "Cervia", "given": "Carlo", "initials": "C", "orcid": "0000-0001-7120-8739", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d0c8b0ac68984748ae12d25bf50fdb5d.json"}}, {"family": "Zurbuchen", "given": "Yves", "initials": "Y", "orcid": "0000-0001-5387-9950", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33558ac87673432f8fa00ecad5b9ff6d.json"}}, {"family": "Hasler", "given": "Sara", "initials": "S", "orcid": "0000-0001-7357-9090", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c600e18dbb448dd91b895bb1c380e0f.json"}}, {"family": "Pou", "given": "Christian", "initials": "C", "orcid": "0000-0003-3932-788X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c43110c557a448a58782ba750b5be26e.json"}}, {"family": "Tan", "given": "Ziyang", "initials": "Z", "orcid": "0000-0002-7205-4978", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c593f081713402cac6296f48bffad51.json"}}, {"family": "Adamo", "given": "Sarah", "initials": "S", "orcid": "0000-0002-6161-3156", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01e7ff62bef7421fac217fab2707ed80.json"}}, {"family": "Raeber", "given": "Miro E", "initials": "ME", "orcid": "0000-0003-2609-0246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a14abc410a94f70987ac309368db2c7.json"}}, {"family": "B\u00e4chli", "given": "Esther", "initials": "E", "orcid": "0000-0003-4887-7576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e861fa430c4243e484b8ba62da346f4b.json"}}, {"family": "Rudiger", "given": "Alain", "initials": "A", "orcid": "0000-0001-7943-7624", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d62bfa03c7a41c9905ea62b34b65ee4.json"}}, {"family": "St\u00fcssi-Helbling", "given": "Melina", "initials": "M", "orcid": "0000-0002-7896-6644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0551149ea92e46d8892abc22c8767683.json"}}, {"family": "Huber", "given": "Lars C", "initials": "LC", "orcid": "0000-0001-5378-4716", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bdd38ab4a3ef45cfacdbfb756d794b9f.json"}}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}, {"family": "Nilsson", "given": "Jakob", "initials": "J", "orcid": "0000-0001-5091-8133", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9289345dc02f4457934c6d2771d5fec4.json"}}, {"family": "Probst-M\u00fcller", "given": "Elsbeth", "initials": "E", "orcid": "0000-0002-9046-4196", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d21e67609d84d13a973f89620b68247.json"}}, {"family": "Boyman", "given": "Onur", "initials": "O", "orcid": "0000-0001-8279-5545", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fd89e300ecc4a2b8d4e31f4d85eef8f.json"}}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": "77", "issue": "8", "pages": "2415-2430", "issn-l": "0105-4538"}, "abstract": "Several autoimmune features occur during coronavirus disease 2019 (COVID-19), with possible implications for disease course, immunity, and autoimmune pathology. In this study, we longitudinally screened for clinically relevant systemic autoantibodies to assess their prevalence, temporal trajectory, and association with immunity, comorbidities, and severity of COVID-19.\n\nWe performed highly sensitive indirect immunofluorescence assays to detect antinuclear antibodies (ANA) and antineutrophil cytoplasmic antibodies (ANCA), along with serum proteomics and virome-wide serological profiling in a multicentric cohort of 175 COVID-19 patients followed up to 1 year after infection, eleven vaccinated individuals, and 41 unexposed controls.\n\nCompared with healthy controls, similar prevalence and patterns of ANA were present in patients during acute COVID-19 and recovery. However, the paired analysis revealed a subgroup of patients with transient presence of certain ANA patterns during acute COVID-19. Furthermore, patients with severe COVID-19 exhibited a high prevalence of ANCA during acute disease. These autoantibodies were quantitatively associated with higher SARS-CoV-2-specific antibody titers in COVID-19 patients and in vaccinated individuals, thus linking autoantibody production to increased antigen-specific humoral responses. Notably, the qualitative breadth of antibodies cross-reactive with other coronaviruses was comparable in ANA-positive and ANA-negative individuals during acute COVID-19. In autoantibody-positive patients, multiparametric characterization demonstrated an inflammatory signature during acute COVID-19 and alterations of the B-cell compartment after recovery.\n\nHighly sensitive indirect immunofluorescence assays revealed transient autoantibody production during acute SARS-CoV-2 infection, while the presence of autoantibodies in COVID-19 patients correlated with increased antiviral humoral immune responses and inflammatory immune signatures.", "doi": "10.1111/all.15302", "pmid": "35364615", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9111424"}], "notes": [], "created": "2022-04-04T06:25:29.101Z", "modified": "2022-08-15T13:03:48.444Z"}, {"entity": "publication", "iuid": "eb05c45ac6734422a5c7c047326fc9a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb05c45ac6734422a5c7c047326fc9a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb05c45ac6734422a5c7c047326fc9a0"}}, "title": "A Cohort Study on Influenza Vaccine and All-Cause Mortality in Older Adults: Methodological Concerns and Public Health Implications.", "authors": [{"family": "Lapi", "given": "Francesco", "initials": "F", "orcid": "0000-0002-4342-9128", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06d5cef5638245d598c8c5ae1a514c33.json"}}, {"family": "Marconi", "given": "Ettore", "initials": "E"}, {"family": "Gualano", "given": "Maria Rosaria", "initials": "MR"}, {"family": "Vetrano", "given": "Davide Liborio", "initials": "DL"}, {"family": "Grattagliano", "given": "Ignazio", "initials": "I"}, {"family": "Rossi", "given": "Alessandro", "initials": "A"}, {"family": "Cricelli", "given": "Claudio", "initials": "C"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Drugs Aging", "issn": "1179-1969", "volume": "39", "issue": "8", "pages": "645-656", "issn-l": null}, "abstract": "In 2020, the restrictions adopted to control the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic led to an unprecedented reduction in influenza-related burden. As such, the reduced chance to characterize the circulating virus strains might have increased the risk of vaccine mismatch for the forthcoming winter seasons. The role of an effective influenza vaccination campaign might therefore assume even more value, especially for frail and multimorbid older individuals. Methodological concerns on confounding by indication are always debated in vaccine effectiveness studies and it might be instrumental to give a pragmatic message on an individual's responsibility to receive the influenza vaccine. We therefore investigated the role of specific confounders to explain the association between influenza vaccine and mortality among older adults.\n\nUsing a primary care database, we formed a cohort of patients aged 65 years or older who were actively registered with their general practitioner (GP) at the beginning of each of nine influenza seasons through to the 2018/2019 season. The study index date was the related seasons' starting date. Exposure to the influenza vaccine was operationally defined in the 2 months preceding the index date up to 2 weeks before the exit date. Cox regression models were estimated to calculate hazard ratios (HRs) and their 95% confidence intervals (CI) of death between vaccinated and unvaccinated patients in a time-dependent fashion. The potential confounders sequentially entered the model based on their increasing effect size observed in univariate analyses.\n\nOver the 10 years under study, the influenza vaccine showed a significant protective effect in terms of mortality, reaching 13% reduction (HR 0.87, 95% CI 0.80-0.95) in the 2018/2019 influenza season. When we estimated the multivariate model by sequentially adding the potential confounders, there was an inversion of HR (below the unit) that was significantly explained by the covariates coding for a prior history of lower respiratory tract infections and the presence of the pneumococcal vaccine.\n\nIn the current pandemic scenario, we cannot divert attention to proper use of face masks, social distancing, and hand hygiene, which are important measures to prevent influenza and other respiratory viral infections. Nonetheless, their effectiveness might be negligible without acceptable coverage for influenza vaccine, especially in older patients with a history of lower respiratory tract infections, which appears to be the main source of confounding by indication.", "doi": "10.1007/s40266-022-00958-7", "pmid": "35867212", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9305032"}, {"db": "pii", "key": "10.1007/s40266-022-00958-7"}], "notes": [], "created": "2022-08-12T08:41:43.205Z", "modified": "2023-06-19T15:30:14.102Z"}, {"entity": "publication", "iuid": "a5692e6b107c42baa428115a1abe000a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a5692e6b107c42baa428115a1abe000a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a5692e6b107c42baa428115a1abe000a"}}, "title": "Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework.", "authors": [{"family": "Clerbaux", "given": "Laure-Alix", "initials": "LA", "orcid": "0000-0003-2707-482X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/939248df1b6a46f38a59237a7b2f75dc.json"}}, {"family": "Albertini", "given": "Maria Cristina", "initials": "MC", "orcid": "0000-0003-4549-1475", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b634e74e14b45e5a0b9e9a36213a0a6.json"}}, {"family": "Amig\u00f3", "given": "N\u00faria", "initials": "N", "orcid": "0000-0002-0116-9145", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4d33dc1cbc84a7ba793dcc6db571cd2.json"}}, {"family": "Beronius", "given": "Anna", "initials": "A", "orcid": "0000-0001-9494-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9dd1a7937ff842d3943b11b4c3459f6e.json"}}, {"family": "Bezemer", "given": "Gillina F G", "initials": "GFG"}, {"family": "Coecke", "given": "Sandra", "initials": "S"}, {"family": "Daskalopoulos", "given": "Evangelos P", "initials": "EP"}, {"family": "Del Giudice", "given": "Giusy", "initials": "G"}, {"family": "Greco", "given": "Dario", "initials": "D", "orcid": "0000-0001-9195-9003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a1b8426cfa14677bf4f48740868c9a8.json"}}, {"family": "Grenga", "given": "Lucia", "initials": "L", "orcid": "0000-0001-5560-1717", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db628fe93ed94326869e52a86a47220c.json"}}, {"family": "Mantovani", "given": "Alberto", "initials": "A"}, {"family": "Mu\u00f1oz", "given": "Amalia", "initials": "A"}, {"family": "Omeragic", "given": "Elma", "initials": "E", "orcid": "0000-0002-5996-4926", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ab6ff466682485ebe5f7d0421b68e6e.json"}}, {"family": "Parissis", "given": "Nikolaos", "initials": "N", "orcid": "0000-0001-9478-0885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bff67e49a37d4969b4e88e8cc93344be.json"}}, {"family": "Petrillo", "given": "Mauro", "initials": "M", "orcid": "0000-0002-6782-4704", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8183c35e5c7b40d1a7ea56a85521451b.json"}}, {"family": "Saarim\u00e4ki", "given": "Laura A", "initials": "LA"}, {"family": "Soares", "given": "Helena", "initials": "H", "orcid": "0000-0002-5881-3843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f70a530898734960b5e71b665ecefedf.json"}}, {"family": "Sullivan", "given": "Kristie", "initials": "K"}, {"family": "Landesmann", "given": "Brigitte", "initials": "B"}], "type": "journal article", "published": "2022-07-31", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "11", "issue": "15", "issn-l": "2077-0383"}, "abstract": "Addressing factors modulating COVID-19 is crucial since abundant clinical evidence shows that outcomes are markedly heterogeneous between patients. This requires identifying the factors and understanding how they mechanistically influence COVID-19. Here, we describe how eleven selected factors (age, sex, genetic factors, lipid disorders, heart failure, gut dysbiosis, diet, vitamin D deficiency, air pollution and exposure to chemicals) influence COVID-19 by applying the Adverse Outcome Pathway (AOP), which is well-established in regulatory toxicology. This framework aims to model the sequence of events leading to an adverse health outcome. Several linear AOPs depicting pathways from the binding of the virus to ACE2 up to clinical outcomes observed in COVID-19 have been developed and integrated into a network offering a unique overview of the mechanisms underlying the disease. As SARS-CoV-2 infectibility and ACE2 activity are the major starting points and inflammatory response is central in the development of COVID-19, we evaluated how those eleven intrinsic and extrinsic factors modulate those processes impacting clinical outcomes. Applying this AOP-aligned approach enables the identification of current knowledge gaps orientating for further research and allows to propose biomarkers to identify of high-risk patients. This approach also facilitates expertise synergy from different disciplines to address public health issues.", "doi": "10.3390/jcm11154464", "pmid": "35956081", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jcm11154464"}, {"db": "pmc", "key": "PMC9369763"}], "notes": [], "created": "2022-08-16T15:41:27.289Z", "modified": "2022-08-16T15:41:48.989Z"}, {"entity": "publication", "iuid": "db6c2aa233d643e591911f4079de01cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db6c2aa233d643e591911f4079de01cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db6c2aa233d643e591911f4079de01cb"}}, "title": "VACCELERATE Volunteer Registry: A European study participant database to facilitate clinical trial enrolment.", "authors": [{"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J"}, {"family": "Stewart", "given": "Fiona A", "initials": "FA"}, {"family": "Heringer", "given": "Sarah", "initials": "S"}, {"family": "Koniordou", "given": "Markela", "initials": "M"}, {"family": "\u00c1lvarez-Barco", "given": "Elena", "initials": "E"}, {"family": "Argyropoulos", "given": "Christos D", "initials": "CD"}, {"family": "Themistocleous", "given": "Sophia C", "initials": "SC"}, {"family": "Valle-Sim\u00f3n", "given": "Paula", "initials": "P"}, {"family": "Spivak", "given": "Orly", "initials": "O"}, {"family": "Sou\u010dkov\u00e1", "given": "Lenka", "initials": "L"}, {"family": "Merakou", "given": "Christina", "initials": "C"}, {"family": "Am\u00e9lia Mendon\u00e7a", "given": "Maria", "initials": "M"}, {"family": "Joanna Davis", "given": "Ruth", "initials": "R"}, {"family": "Maria Azzini", "given": "Anna", "initials": "A"}, {"family": "Askling", "given": "Helena H", "initials": "HH"}, {"family": "Vene", "given": "Sirkka", "initials": "S"}, {"family": "Van Damme", "given": "Pierre", "initials": "P"}, {"family": "Steinbach", "given": "Angela", "initials": "A"}, {"family": "Shiamakkides", "given": "George", "initials": "G"}, {"family": "Seidel", "given": "Danila", "initials": "D"}, {"family": "Olesen", "given": "Ole F", "initials": "OF"}, {"family": "Noula", "given": "Evgenia", "initials": "E"}, {"family": "Macken", "given": "Alan", "initials": "A"}, {"family": "Lu\u00eds", "given": "Catarina", "initials": "C"}, {"family": "Leckler", "given": "Janina", "initials": "J"}, {"family": "Launay", "given": "Odile", "initials": "O"}, {"family": "Isitt", "given": "Catherine", "initials": "C"}, {"family": "Hellemans", "given": "Margot", "initials": "M"}, {"family": "Fr\u00edas-Iniesta", "given": "Jes\u00fas", "initials": "J"}, {"family": "Di Marzo", "given": "Romina", "initials": "R"}, {"family": "Carcas", "given": "Antonio J", "initials": "AJ"}, {"family": "Boustras", "given": "George", "initials": "G"}, {"family": "Borobia", "given": "Alberto M", "initials": "AM"}, {"family": "Barta", "given": "Imre", "initials": "I"}, {"family": "Albus", "given": "Kerstin", "initials": "K"}, {"family": "Akova", "given": "Murat", "initials": "M"}, {"family": "Ochando", "given": "Jordi", "initials": "J"}, {"family": "Cohen-Kandli", "given": "Miriam", "initials": "M"}, {"family": "Jane Cox", "given": "Rebecca", "initials": "R"}, {"family": "Husa", "given": "Petr", "initials": "P"}, {"family": "Jancoriene", "given": "Ligita", "initials": "L"}, {"family": "Mallon", "given": "Patrick", "initials": "P"}, {"family": "Marques", "given": "Laura", "initials": "L"}, {"family": "Mellinghoff", "given": "Sibylle C", "initials": "SC"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}, {"family": "Tacconelli", "given": "Evelina", "initials": "E"}, {"family": "T\u00f3th", "given": "Krisztina", "initials": "K"}, {"family": "Zaoutis", "given": "Theoklis E", "initials": "TE"}, {"family": "Zeitlinger", "given": "Markus", "initials": "M"}, {"family": "Cornely", "given": "Oliver A", "initials": "OA"}, {"family": "Pana", "given": "Zoi-Dorothea", "initials": "ZD"}, {"family": "VACCELERATE consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-29", "journal": {"title": "Vaccine", "issn": "1873-2518", "volume": "40", "issue": "31", "pages": "4090-4097", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has evidenced the key role of vaccine design, obtention, production and administration to successfully fight against infectious diseases and to provide efficient remedies for the citizens. Although clinical trials were rapidly established during this pandemic, identifying suitable study subjects can be challenging. For this reason, the University Hospital Cologne established a volunteer registry for participation in clinical trials first in Germany, which has now been incorporated into the European VACCELERATE clinical trials network and grew to a European Volunteer Registry. As such, VACCELERATE's Volunteer Registry aims to become a common entry point for potential volunteers in future clinical trials in Europe.\n\nInterested volunteers who would like to register for clinical trials in the VACCELERATE Volunteer Registry can access the registration questionnaire via http://www.vaccelerate.eu/volunteer-registry. Potential volunteers are requested to provide their current country and area of residence, contact information, including first and last name and e-mail address, age, gender, comorbidities, previous SARS-CoV-2 infection and vaccination status, and maximum distance willing to travel to a clinical trial site. The registry is open to both adults and children, complying with national legal consent requirements.\n\nAs of May 2022, the questionnaire is available in 12 countries and 14 languages. Up to date, more than 36,000 volunteers have registered, mainly from Germany. Within the first year since its establishment, the VACCELERATE Volunteer Registry has matched more than 15,000 volunteers to clinical trials. The VACCELERATE Volunteer Registry will be launched in further European countries in the coming months.\n\nThe VACCELERATE Volunteer Registry is an active single-entry point for European residents interested in COVID-19 clinical trials participation in 12 countries (i.e., Austria, Cyprus, Germany, Greece, Ireland, Lithuania, Norway, Portugal, Spain, Sweden and Turkey). To date, more than 15,000 registered individuals have been connected to clinical trials in Germany alone. The registry is currently in the implementation phase in 5 additional countries (i.e., Belgium, Czech Republic, Hungary, Israel and the Netherlands).", "doi": "10.1016/j.vaccine.2022.05.022", "pmid": "35659449", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(22)00605-3"}], "notes": [], "created": "2022-06-21T17:17:31.581Z", "modified": "2022-06-21T17:17:31.596Z"}, {"entity": "publication", "iuid": "bdf06c9002824a688b8b0092806ac1e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bdf06c9002824a688b8b0092806ac1e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bdf06c9002824a688b8b0092806ac1e1"}}, "title": "Serum concentration of extracellular cold-inducible RNA-binding protein is associated with respiratory failure in COVID-19.", "authors": [{"family": "Schagatay", "given": "Felix", "initials": "F"}, {"family": "Diamant", "given": "Klara", "initials": "K"}, {"family": "Lid\u00e9n", "given": "Mats", "initials": "M"}, {"family": "Edin", "given": "Alicia", "initials": "A"}, {"family": "Athlin", "given": "Simon", "initials": "S"}, {"family": "Hultgren", "given": "Olof", "initials": "O"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Savilampi", "given": "Johanna", "initials": "J"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Lange", "given": "Anna", "initials": "A"}, {"family": "Cajander", "given": "Sara", "initials": "S"}], "type": "journal article", "published": "2022-07-29", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "13", "pages": "945603", "issn-l": "1664-3224"}, "abstract": "Uncontrolled release of damage-associated molecular patterns (DAMPs) is suggested to be a major trigger for the dysregulated host immune response that leads to severe COVID-19. Cold-inducible RNA-binding protein (CIRP), is a newly identified DAMP that aggravates inflammation and tissue injury, and induces respiratory failure in sepsis. Whether CIRP contributes to the pathogenesis of respiratory failure in COVID-19 has not yet been explored.\n\nTo investigate if the concentration of extracellular CIRP (eCIRP) in serum associates with respiratory failure and lung involvement by chest computed tomography (CT) in COVID-19.\n\nHerein we report a prospective observational study of patients with COVID-19 included at two University Hospitals in Sweden between April 2020 and May 2021. Serum from hospitalized patients in \u00d6rebro (N=97) were used to assess the association between eCIRP and the level of respiratory support and its correlation with pulmonary involvement on chest CT and inflammatory biomarkers. A cohort of hospitalized and non-hospitalized patients from Ume\u00e5 (N=78) was used as an external validation cohort. The severity of disease was defined according to the highest degree of respiratory support; mild disease (no oxygen), non-severe hypoxemia (conventional oxygen or high-flow nasal oxygen, HFNO <50% FiO2), and severe hypoxemia (HFNO \u226550% FiO2, mechanical ventilation). Unadjusted and adjusted linear regression was used to evaluate peak eCIRP day 0-4 in respect to severity, age, sex, Charlson comorbidity score, symptom duration, and BMI.\n\nPeak eCIRP concentrations were higher in patients with severe hypoxemia and were independently associated with the degree of respiratory support in both cohorts (\u00d6rebro; p=0.01, Ume\u00e5; p<0.01). The degree of pulmonary involvement measured by CT correlated with eCIRP, rs=0.30, p<0.01 (n=97).\n\nHigh serum levels of eCIRP are associated with acute respiratory failure in COVID-19. Experimental studies are needed to determine if treatments targeting eCIRP reduces the risk of acute respiratory failure in COVID-19.", "doi": "10.3389/fimmu.2022.945603", "pmid": "35967397", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9373926"}], "notes": [], "created": "2022-08-16T15:37:26.634Z", "modified": "2022-08-19T05:27:23.777Z"}, {"entity": "publication", "iuid": "0d58d4714dae496c88ba1233e54f236e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d58d4714dae496c88ba1233e54f236e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d58d4714dae496c88ba1233e54f236e"}}, "title": "Healthy workplace onboard: Insights gained from the COVID-19 impact on mental health and wellbeing of seafarers.", "authors": [{"family": "Carrera-Arce", "given": "Maria", "initials": "M"}, {"family": "Bartusevi\u010dien\u0117", "given": "Inga", "initials": "I"}, {"family": "Divari", "given": "Paschalia", "initials": "P"}], "type": "journal article", "published": "2022-07-29", "journal": {"title": "Work", "issn": "1875-9270", "issn-l": null}, "abstract": "Seafarers' psychological health is seriously affected by COVID-19. The pandemic could act as a catalyst for change with respect to seafarers' mental health protection and promotion.\n\nThe study explores the main factors contributing to the mental health and wellbeing of seafarers. Moreover, elements to help seafarers lessen the impact of the pandemic on their work and life onboard are analyzed, and their role in developing a positive psychosocial environment and promoting a healthy workplace onboard are discussed.\n\nThe study involved the use of an ad hoc questionnaire and the adoption of both quantitative and qualitative methods. The sample included one hundred and five active seafarers.\n\nNinety-six percent of the sample stated that mental health is a very or extremely important part of their general health. Seafarers perceive that their mental health has been seriously impacted by COVID-19. Major factors contributing to seafarers' mental health and wellbeing reveal three groups of factors: rest and spare time-related factors, communication/relationship with the external world, and interaction and social life on board factors.\n\nStrategies suggested by seafarers for coping with \"inevitable\" psychological stress produced by COVID-19 and promoting their wellbeing include managerial, emotional, facilities-related (including communication infrastructure), physical, and social elements to promote wellbeing. Economic, intellectual, and spiritual elements also have to be taken into consideration and require further investigation. Building on seafarers' insights and experiences, a healthy environment onboard should cultivate holistically the four main spheres of a healthy workplace (physical work environment, psychosocial work environment, personal health resources, and enterprise community involvement) and the five features of a healthy psychosocial environment (social, emotional, physical, intellectual and spiritual) under all circumstances, whether exceptional or ordinary.", "doi": "10.3233/WOR-210791", "pmid": "35912771", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "WOR210791"}], "notes": [], "created": "2022-08-11T12:04:07.487Z", "modified": "2022-08-11T12:04:07.502Z"}, {"entity": "publication", "iuid": "853c5874292242dea1b45360476495d6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/853c5874292242dea1b45360476495d6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/853c5874292242dea1b45360476495d6"}}, "title": "Protein Expression Profile of ACE2 in the Normal and COVID-19-Affected Human Brain.", "authors": [{"family": "Lindskog", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-5611-1015", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4ead3d38a364b66ac069b9c8bf63897.json"}}, {"family": "M\u00e9ar", "given": "Loren", "initials": "L", "orcid": "0000-0001-9333-0110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/344121b8f2524853a820ad52ea8de328.json"}}, {"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "F\u00e4llmar", "given": "David", "initials": "D"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Hesselager", "given": "G\u00f6ran", "initials": "G"}, {"family": "Casar-Borota", "given": "Olivera", "initials": "O"}, {"family": "Rostami", "given": "Elham", "initials": "E"}], "type": "journal article", "published": "2022-07-28", "journal": {"title": "J Proteome Res", "issn": "1535-3907", "issn-l": null}, "abstract": "SARS-coronavirus 2 (SARS-CoV-2) that caused the coronavirus disease 2019 (COVID-19) pandemic has posed to be a global challenge. An increasing number of neurological symptoms have been linked to the COVID-19 disease, but the underlying mechanisms of such symptoms and which patients could be at risk are not yet established. The suggested key receptor for host cell entry is angiotensin I converting enzyme 2 (ACE2). Previous studies on limited tissue material have shown no or low protein expression of ACE2 in the normal brain. Here, we used stringently validated antibodies and immunohistochemistry to examine the protein expression of ACE2 in all major regions of the normal brain. The expression pattern was compared with the COVID-19-affected brain of patients with a varying degree of neurological symptoms. In the normal brain, the expression was restricted to the choroid plexus and ependymal cells with no expression in any other brain cell types. Interestingly, in the COVID-19-affected brain, an upregulation of ACE2 was observed in endothelial cells of certain patients, most prominently in the white matter and with the highest expression observed in the patient with the most severe neurological symptoms. The data shows differential expression of ACE2 in the diseased brain and highlights the need to further study the role of endothelial cells in COVID-19 disease in relation to neurological symptoms.", "doi": "10.1021/acs.jproteome.2c00184", "pmid": "35901083", "labels": {"Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9364976"}], "notes": [], "created": "2022-08-12T08:32:57.108Z", "modified": "2022-08-12T08:32:57.176Z"}, {"entity": "publication", "iuid": "fd6adaa59c1f4e41bc3b8161bc015a7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fd6adaa59c1f4e41bc3b8161bc015a7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fd6adaa59c1f4e41bc3b8161bc015a7e"}}, "title": "From novel discovery tools and biomarkers to precision medicine - basic cardiovascular science highlights of 2021/2022.", "authors": [{"family": "Evans", "given": "Paul C", "initials": "PC", "orcid": "0000-0001-7975-681X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9bbd82269e844d92bdb953d9544fbc84.json"}}, {"family": "Davidson", "given": "Sean M", "initials": "SM"}, {"family": "Wojta", "given": "Johann", "initials": "J", "orcid": "0000-0002-1282-9276", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceed4186b4864c1e83d4dbaa35465b2c.json"}}, {"family": "B\u00e4ck", "given": "Magnus", "initials": "M"}, {"family": "Bollini", "given": "Sveva", "initials": "S"}, {"family": "Brittan", "given": "Mairi", "initials": "M", "orcid": "0000-0002-3830-200X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41994a2430ff4dfc82a5e2b95da0cef2.json"}}, {"family": "Catapano", "given": "Alberico L", "initials": "AL", "orcid": "0000-0002-7593-2094", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9be6543658dc4243b3692badcfb51112.json"}}, {"family": "Chaudhry", "given": "Bill", "initials": "B"}, {"family": "Cluitmans", "given": "Matthijs", "initials": "M"}, {"family": "Gnecchi", "given": "Massimiliano", "initials": "M", "orcid": "0000-0001-7435-4328", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b080766181f34bc6aaa22bf38a356839.json"}}, {"family": "Guzik", "given": "Tomasz J", "initials": "TJ", "orcid": "0000-0003-2012-1187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bba211a5749d45668559282301691367.json"}}, {"family": "Hoefer", "given": "Imo", "initials": "I"}, {"family": "Madonna", "given": "Rosalinda", "initials": "R", "orcid": "0000-0001-6455-2777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/628e83f26bb44f578c343e8801a9c848.json"}}, {"family": "Monteiro", "given": "Jo\u00e3o P", "initials": "JP"}, {"family": "Morawietz", "given": "Henning", "initials": "H"}, {"family": "Osto", "given": "Elena", "initials": "E", "orcid": "0000-0001-8196-5696", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8748792f9b8b412abbe0bdb9f5339adb.json"}}, {"family": "Padr\u00f3", "given": "Teresa", "initials": "T"}, {"family": "Sluimer", "given": "Judith C", "initials": "JC"}, {"family": "Tocchetti", "given": "Carlo Gabriele", "initials": "CG"}, {"family": "Van der Heiden", "given": "Kim", "initials": "K", "orcid": "0000-0002-6537-5992", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3450039095254822b1b3fae6a9b70720.json"}}, {"family": "Vilahur", "given": "Gemma", "initials": "G"}, {"family": "Waltenberger", "given": "Johannes", "initials": "J", "orcid": "0000-0002-2417-9880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92915958f5aa420d9562819756473451.json"}}, {"family": "Weber", "given": "Christian", "initials": "C", "orcid": "0000-0003-4610-8714", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c44b7ca02c624d62be15c61fcf389d54.json"}}], "type": "journal article", "published": "2022-07-28", "journal": {"title": "Cardiovasc Res", "issn": "1755-3245", "issn-l": null}, "abstract": "Here we review the highlights of cardiovascular basic science in published in 2021 and early 2022 on behalf of the European Society of Cardiology Council for Basic Cardiovascular Science. We begin with non-coding RNAs which have emerged as central regulators cardiovascular biology, and then discuss how technological developments in single-cell 'omics are providing new insights in cardiovascular development, inflammation and disease. We also review recent discoveries on the biology of extracellular vesicles in driving either protective or pathogenic responses. The Nobel Prize in Physiology or Medicine 2021 recognised the importance of the molecular basis of mechanosensing and here we review breakthroughs in cardiovascular sensing of mechanical force. We also summarise discoveries in the field of atherosclerosis including the role of clonal haematopoiesis of indeterminate potential, and new mechanisms of cross-talk between hyperglycemia, lipid mediators and inflammation. The past 12 months also witnessed major advances in the field of cardiac arrhythmia including new mechanisms of fibrillation. We also focus on inducible pluripotent stem cell (iPSC) technology which has demonstrated disease causality for several genetic polymorphisms in long QT syndrome and aortic valve disease, paving the way for personalized medicine approaches. Finally, the cardiovascular community has continued to better understand COVID-19 with significant advancement in our knowledge of cardiovascular tropism, molecular markers, the mechanism of vaccine-induced thrombotic complications and new anti-viral therapies that protect the cardiovascular system.", "doi": "10.1093/cvr/cvac114", "pmid": "35899362", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6650923"}], "notes": [], "created": "2022-08-12T08:33:39.207Z", "modified": "2022-08-12T08:33:39.606Z"}, {"entity": "publication", "iuid": "ac4dffd654da4755949ea87002895b09", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac4dffd654da4755949ea87002895b09.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac4dffd654da4755949ea87002895b09"}}, "title": "Sociodemographic and Occupational Factors Associated with Low Early Uptake of COVID-19 Vaccine in Hospital-Based Healthcare Workers, Georgia, March-July 2021.", "authors": [{"family": "Lucaccioni", "given": "H\u00e9lo\u00efse", "initials": "H", "orcid": "0000-0003-3080-9794", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5850aabf8a674ee2971fe111b880aeba.json"}}, {"family": "Chakhunashvili", "given": "Giorgi", "initials": "G"}, {"family": "McKnight", "given": "Carl Jason", "initials": "CJ"}, {"family": "Zardiashvili", "given": "Tamila", "initials": "T"}, {"family": "Jorgensen", "given": "Pernille", "initials": "P"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "Kissling", "given": "Esther", "initials": "E"}, {"family": "Katz", "given": "Mark A", "initials": "MA", "orcid": "0000-0002-5532-7276", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/890f00845e274820b1b78a0829f4d01f.json"}}, {"family": "Sanodze", "given": "Lia", "initials": "L"}], "type": "journal article", "published": "2022-07-27", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "In Georgia, an upper-middle income European country, the COVID-19 vaccine rollout began on 15 March 2021 with health workers (HWs), a priority group for vaccination. We assessed the factors associated with COVID-19 vaccination among HWs at six large hospitals in the early stages of the vaccine rollout (March-July 2021). Among 1533 HWs, 274 (17.9%) had received one dose of the COVID-19 vaccine. Strong independent predictors of early vaccine uptake were age &gt; 40 years, especially 50-59 years old (aOR 2.40, 95% CI 1.50-3.88), considering the vaccine as \"somewhat effective\" or \"very effective\" rather than \"not effective\" (aOR 6.33, 95% CI 2.29-26.3 and aOR 10.9, 95% CI 3.88-45.70, respectively), and previous vaccination against seasonal influenza (aOR 2.98, 95% CI 2.19-4.08). Previous SARS-CoV-2 infection was negatively associated with receiving the vaccine (aOR 0.6, 95% CI 0.40-0.80). Compared to physicians, nurses/midwives (aOR 0.22, 95% CI 0.15-0.32), administrative staff (aOR 0.36, 95% CI 0.22-0.56), and ancillary staff (aOR 0.07, 95% CI 0.04-0.15) were less likely to have received the COVID-19 vaccine. Tailoring the COVID-19 vaccine communications campaign to younger and non-physician HWs, and emphasizing the benefits of the COVID-19 vaccine, could help further increase vaccine coverage among HWs in Georgia.", "doi": "10.3390/vaccines10081197", "pmid": "36016084", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "vaccines10081197"}, {"db": "pmc", "key": "PMC9415840"}], "notes": [], "created": "2022-09-12T19:09:52.564Z", "modified": "2022-09-12T19:10:59.840Z"}, {"entity": "publication", "iuid": "838d5e0781814dc0b5b565581bd02829", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/838d5e0781814dc0b5b565581bd02829.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/838d5e0781814dc0b5b565581bd02829"}}, "title": "Silence Among First-Line Managers in Eldercare and Their Continuous Improvement Work During Covid-19.", "authors": [{"family": "Dellve", "given": "Lotta", "initials": "L", "orcid": "0000-0003-0480-1895", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/796e0052b7eb49629ac24f9fc455ce5a.json"}}, {"family": "Jendeby", "given": "Mimmi Kheddache", "initials": "MK", "orcid": "0000-0002-9756-0607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef79afa452a845f18b07a3963567e045.json"}}], "type": "journal article", "published": "2022-07-27", "journal": {"title": "Inquiry", "issn": "1945-7243", "volume": "59", "pages": "469580221107052", "issn-l": null}, "abstract": "Eldercare sector faced severe needs, and unexplained difficulties, to manage daily work and the continuous improvement of routines at operative levels during Covid-19. First-line managers in eldercare have a key role to facilitate learnings but may be hindered in public, hierarchical organizations. This is the first study on the conditions and importance of silence for managerial work in terms of daily operations and continuous improvement work. To identify first-line managers' silence in eldercare, its contextual and supportive conditions, its reasons and its implications for managerial work with regard to daily operations and continuous improvement work. Mixed-method study based on a questionnaire to first-line managers (n = 189) in Swedish public eldercare in 33 randomly selected municipal organizations and one city. The instruments Communication of Critical Issues at Work, Managers Stress Inventory and Managerial Work and an open question were analyzed using: (1) qualitative coding to explore organizational conditions, (2) descriptive statistics, and (3) stepwise regressions to identify associations. The most common forms of silence were quiescent (based on fear of the consequences of speaking up) and acquiescent (based on resignation and demotivation). Organizational conditions shaping managerial silence were due to strict governance and control in a hierarchical organization, lack of support and participation in decision-making and the experience of not being valued. Managers' silence had a negative impact on managerial work and especially work on continuous improvements. The pandemic also offered space for values of occupational professionalism and learning at operational levels. Organizational conditions of support through superiors and management teams decreased silence. Manager silence is detrimental for continuous improvement work and may arise in organizations with dominant values of organizational professionalism. Supportive conditions based on trust and space for occupational professionalism may be important and should be improved to decrease managerial silence and better support continuous improvements.", "doi": "10.1177/00469580221107052", "pmid": "35880855", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9340405"}], "notes": [], "created": "2022-08-12T08:38:02.656Z", "modified": "2022-08-12T08:38:02.745Z"}, {"entity": "publication", "iuid": "38d6d243fdea4bc899b9df57c001eb57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38d6d243fdea4bc899b9df57c001eb57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38d6d243fdea4bc899b9df57c001eb57"}}, "title": "NMR Experiments Provide Insights into Ligand-Binding to the SARS-CoV-2 Spike Protein Receptor-Binding Domain.", "authors": [{"family": "Creutznacher", "given": "Robert", "initials": "R"}, {"family": "Maass", "given": "Thorben", "initials": "T"}, {"family": "Veselkova", "given": "Barbora", "initials": "B"}, {"family": "Ssebyatika", "given": "George", "initials": "G"}, {"family": "Krey", "given": "Thomas", "initials": "T"}, {"family": "Empting", "given": "Martin", "initials": "M"}, {"family": "Tautz", "given": "Norbert", "initials": "N"}, {"family": "Frank", "given": "Martin", "initials": "M"}, {"family": "K\u00f6lbel", "given": "Knut", "initials": "K"}, {"family": "Uetrecht", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1991-7922", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb624da1299f4c7fb23cbb6ed98d5338.json"}}, {"family": "Peters", "given": "Thomas", "initials": "T", "orcid": "0000-0002-7570-8260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f8c890c3f7e4b1688e247f1920fafa8.json"}}], "type": "journal article", "published": "2022-07-27", "journal": {"title": "J Am Chem Soc", "issn": "1520-5126", "volume": "144", "issue": "29", "pages": "13060-13065", "issn-l": null}, "abstract": "We have used chemical shift perturbation (CSP) and saturation transfer difference (STD) NMR experiments to identify and characterize the binding of selected ligands to the receptor-binding domain (RBD) of the spike glycoprotein (S-protein) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We also subjected full-length S-protein to STD NMR experiments, allowing correlations with RBD-based results. CSPs reveal the binding sites for heparin and fondaparinux, and affinities were measured using CSP titrations. We then show that \u03b1-2,3-sialyllactose binds to the S-protein but not to the RBD. Finally, combined CSP and STD NMR experiments show that lifitegrast, a compound used for the treatment of dry eye, binds to the linoleic acid (LA) binding pocket with a dissociation constant in the \u03bcM range. This is an interesting finding, as lifitegrast lends itself well as a blueprint for medicinal chemistry, eventually furnishing novel entry inhibitors targeting the highly conserved LA binding site.", "doi": "10.1021/jacs.2c05603", "pmid": "35830336", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-17T10:35:23.171Z", "modified": "2022-08-17T10:36:02.991Z"}, {"entity": "publication", "iuid": "65043fd61ce841a99504d2db8c4cb5e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65043fd61ce841a99504d2db8c4cb5e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65043fd61ce841a99504d2db8c4cb5e8"}}, "title": "Macrotroponin Complex as a Cause for Cardiac Troponin Increase after COVID-19 Vaccination and Infection.", "authors": [{"family": "Bularga", "given": "Anda", "initials": "A", "orcid": "0000-0002-5530-527X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91b19a9407f94a29aaa1c010933a5971.json"}}, {"family": "Oskoui", "given": "Ellen", "initials": "E"}, {"family": "Fujisawa", "given": "Takeshi", "initials": "T"}, {"family": "Jenks", "given": "Sara", "initials": "S"}, {"family": "Sutherland", "given": "Rachel", "initials": "R"}, {"family": "Apple", "given": "Fred S", "initials": "FS"}, {"family": "Hammarsten", "given": "Ola", "initials": "O"}, {"family": "Mills", "given": "Nicholas L", "initials": "NL", "orcid": "0000-0003-0533-7991", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c76e317e697744878fd74d19e720df4c.json"}}], "type": "journal article", "published": "2022-07-27", "journal": {"title": "Clin Chem", "issn": "1530-8561", "volume": "68", "issue": "8", "pages": "1015-1019", "issn-l": "0009-9147"}, "abstract": null, "doi": "10.1093/clinchem/hvac100", "pmid": "35896175", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6650785"}], "notes": [], "created": "2022-08-12T08:34:39.276Z", "modified": "2022-08-12T08:34:39.362Z"}, {"entity": "publication", "iuid": "fab6ff995328484bb42b4f6f4ee2375f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fab6ff995328484bb42b4f6f4ee2375f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fab6ff995328484bb42b4f6f4ee2375f"}}, "title": "Hypertension in COVID-19, A Risk Factor for Infection or A Late Consequence?", "authors": [{"family": "Barekat", "given": "Maryam", "initials": "M"}, {"family": "Shahrbaf", "given": "Mohammad Amin", "initials": "MA"}, {"family": "Rahi", "given": "Kosar", "initials": "K"}, {"family": "Vosough", "given": "Massoud", "initials": "M"}], "type": "journal article", "published": "2022-07-27", "journal": {"title": "Cell J", "issn": "2228-5806", "volume": "24", "issue": "7", "pages": "424-426", "issn-l": null}, "abstract": "There are a lot of data about the correlation of SARS-CoV-2 infection and hypertension (HTN), but most of them are in the increased risk of morbidity and mortality in patients with HTN. SARS-CoV-2 can interfere with host cells through the renin-angiotensin system (RAS) via the angiotensin-converting enzyme 2 (ACE2) receptor. RAS activation is associated with pro-inflammatory effects through the ACE/Ang II/ Angiotensin II type 1 receptor (AT1R) pathway or anti-inflammatory effects through ACE2/Ang1-7/Mas axis. In the current paper, we discuss the pathophysiology of newly diagnosed HTN and its effect on morbidity in patients with coronavirus disease 2019 (COVID-19).", "doi": "10.22074/cellj.2022.8487", "pmid": "36043411", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9428472"}], "notes": [], "created": "2022-10-13T13:05:46.781Z", "modified": "2022-10-13T13:05:46.809Z"}, {"entity": "publication", "iuid": "e78151a5b69344e8ab24d133a2f328e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e78151a5b69344e8ab24d133a2f328e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e78151a5b69344e8ab24d133a2f328e8"}}, "title": "Transient and durable T cell reactivity after COVID-19.", "authors": [{"family": "Martner", "given": "Anna", "initials": "A", "orcid": "0000-0002-6598-5221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c11a2e719c534772a129782bfb60d35c.json"}}, {"family": "Grauers Wiktorin", "given": "Hanna", "initials": "H", "orcid": "0000-0002-4412-5695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a08f604e1f94feda4e60f01d728e68f.json"}}, {"family": "T\u00f6rnell", "given": "Andreas", "initials": "A", "orcid": "0000-0003-0769-2815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0e49354b88f4f7c8792dfb4216561c8.json"}}, {"family": "Ringlander", "given": "Johan", "initials": "J", "orcid": "0000-0002-8483-6504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64f85af7dceb436498422e62f1a98c89.json"}}, {"family": "Arabpour", "given": "Mohammad", "initials": "M"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-6617-5976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7bda9f192dc44c587d8a252ef16516b.json"}}], "type": "journal article", "published": "2022-07-26", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "119", "issue": "30", "pages": "e2203659119", "issn-l": "0027-8424"}, "abstract": "This study analyzed whole blood samples (n = 56) retrieved from 30 patients at 1 to 21 (median 9) mo after verified COVID-19 to determine the polarity and duration of antigen-specific T cell reactivity against severe acute respiratory syndrome coronavirus 2-derived antigens. Multimeric peptides spanning the entire nucleocapsid protein triggered strikingly synchronous formation of interleukin (IL)-4, IL-12, IL-13, and IL-17 ex vivo until \u223c70 d after confirmed infection, whereafter this reactivity was no longer inducible. In contrast, levels of nucleocapsid-induced IL-2 and interferon-\u03b3 remained stable and highly correlated at 3 to 21 mo after infection. Similar cytokine dynamics were observed in unvaccinated, convalescent patients using whole-blood samples stimulated with peptides spanning the N-terminal portion of the spike 1 protein. These results unravel two phases of T cell reactivity following natural COVID-19: an early, synchronous response indicating transient presence of multipolar, antigen-specific T helper (TH) cells followed by an equally synchronous and durable TH1-like reactivity reflecting long-lasting T cell memory.", "doi": "10.1073/pnas.2203659119", "pmid": "35858456", "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9335198"}], "notes": [], "created": "2022-08-12T08:44:58.936Z", "modified": "2022-08-12T08:45:19.541Z"}, {"entity": "publication", "iuid": "9fab4c18e8884e05879f96f6e51a805a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9fab4c18e8884e05879f96f6e51a805a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9fab4c18e8884e05879f96f6e51a805a"}}, "title": "Examining the relationship between alcohol consumption, psychological distress and COVID-19 related circumstances: An Australian longitudinal study in the first year of the pandemic.", "authors": [{"family": "Mojica-Perez", "given": "Yvette", "initials": "Y"}, {"family": "Livingston", "given": "Michael", "initials": "M"}, {"family": "Pennay", "given": "Amy", "initials": "A"}, {"family": "Callinan", "given": "Sarah", "initials": "S"}], "type": "journal article", "published": "2022-07-26", "journal": {"title": "Addict Behav", "issn": "1873-6327", "volume": "135", "pages": "107439", "issn-l": null}, "abstract": "The aim of this study is to examine the relationship between alcohol consumption, psychological distress and COVID-19 related circumstances (being in lockdown, working from home, providing home-schooling and being furloughed) over the first eight months of the pandemic in Australia.\n\nA longitudinal study with six survey waves over eight months with a convenience sample of 770 participants. Participants were aged 18 or over, lived in Australia and consumed alcohol at least monthly. Demographic data was obtained in the first wave. Data on alcohol consumption, psychological distress (Kessler 10), and COVID-19 related circumstances (being in lockdown, working from home, providing home-schooling and being furloughed) were obtained in each survey wave.\n\nResults from the fixed-effect bivariate regression analyses show that participants reported greater alcohol consumption when they had high psychological distress compared to when they had low psychological distress. Meanwhile, participants reported greater alcohol consumption when they worked from home compared to when they did not work from home. Participants also reported greater alcohol consumption when they provided home-schooling compared with when they did not provide home-schooling. The fixed-effect panel multivariable regression analyses indicated a longitudinal relationship between higher psychological distress and providing home-schooling on increased alcohol consumption.\n\nBroader drinking trends during the COVID-19 pandemic typically indicate increases and decreases in drinking among different members of the population. This study demonstrates that in Australia, it was those who experienced psychological distress and specific impacts of COVID-19 restrictions that were more likely to increase their drinking.", "doi": "10.1016/j.addbeh.2022.107439", "pmid": "35914417", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0306-4603(22)00205-2"}, {"db": "pmc", "key": "PMC9316938"}], "notes": [], "created": "2022-08-11T12:03:50.721Z", "modified": "2022-08-11T12:03:50.763Z"}, {"entity": "publication", "iuid": "081d960b8d3d42cfa84e0fbd8d246cd8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/081d960b8d3d42cfa84e0fbd8d246cd8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/081d960b8d3d42cfa84e0fbd8d246cd8"}}, "title": "Assessing the effectiveness of public health interventions for Covid-19 in Greece and Cyprus.", "authors": [{"family": "Zahariadis", "given": "Nikolaos", "initials": "N"}, {"family": "Exadaktylos", "given": "Theofanis", "initials": "T"}, {"family": "Sparf", "given": "J\u00f6rgen", "initials": "J"}, {"family": "Petridou", "given": "Evangelia", "initials": "E"}, {"family": "Kyriakidis", "given": "Alexandros", "initials": "A"}, {"family": "Papadopoulos", "given": "Ioannis", "initials": "I"}], "type": "journal article", "published": "2022-07-26", "journal": {"title": "Eur Policy Anal", "issn": "2380-6567", "issn-l": null}, "abstract": "In this article, we statistically examine the effectiveness of non-pharmaceutical interventions (NPIs) implemented by the national governments of Greece and Cyprus during 2020 to (a) limit the spread of the SARS-CoV-2 virus, and (b) mitigate the economic fallout brought about by the Covid-19 pandemic. Applying a modified health belief model, we hypothesize that behavioral outcomes at the policy level are a function of NPIs, perceived severity, and social context. We employ a Prais-Winsten estimation in 2-week averages and report panel-corrected standard errors to find that NPIs have clear, yet differential, effects on public health and the economy in terms of statistical significance and time lags. The study provides a critical framework to inform future interventions during emerging pandemics.", "doi": "10.1002/epa2.1153", "pmid": "35942067", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "EPA21153"}, {"db": "pmc", "key": "PMC9349912"}], "notes": [], "created": "2022-08-11T11:49:57.708Z", "modified": "2022-08-11T11:50:13.852Z"}, {"entity": "publication", "iuid": "b1eda1cb4a3a4ebd9a243040fd49a220", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1eda1cb4a3a4ebd9a243040fd49a220.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1eda1cb4a3a4ebd9a243040fd49a220"}}, "title": "Adolescents' Experience of Stress: A Focus Group Interview Study with 16-19-Year-Old Students during the COVID-19 Pandemic.", "authors": [{"family": "Perming", "given": "Camilla", "initials": "C"}, {"family": "Thurn", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Garmy", "given": "Pernilla", "initials": "P", "orcid": "0000-0003-1643-0171", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc4733a9e87a42fea6e7a7323feb61b3.json"}}, {"family": "Einberg", "given": "Eva-Lena", "initials": "EL", "orcid": "0000-0002-5586-3810", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d67e636861d492fb682ec1601422cd0.json"}}], "type": "journal article", "published": "2022-07-26", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "15", "issn-l": null}, "abstract": "The purpose was to investigate stress among adolescents (16-19 years old) during the coronavirus disease 2019 (COVID-19) pandemic. Focus group (n = 9) interviews with students at upper secondary schools (16-19 years old, n = 41) were conducted in southern Sweden during the COVID-19 pandemic in 2021. The interviews were analyzed by qualitative content analysis. The analysis revealed five categories of experience of stress: (1) School-related stress, (2) Stress in relationships and leisure, (3) How stress manifests itself, (4) Stress can increase performance, and (5) Experiences of counteracting stress. The adolescents in the study experienced stress linked to school and relationships, partly due to the COVID-19 pandemic. Distance education during the COVID-19 pandemic increased stress levels. The adolescents stated that high stress levels were experienced negatively and impaired their ability to perform, while moderate stress could contribute to achieving goals and improving performance. School nurses and other health professionals who meet with adolescents are important to support adolescents experiencing stress.", "doi": "10.3390/ijerph19159114", "pmid": "35897483", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19159114"}, {"db": "pmc", "key": "PMC9331051"}], "notes": [], "created": "2022-08-12T08:34:09.420Z", "modified": "2022-08-12T08:34:09.460Z"}, {"entity": "publication", "iuid": "27e5c782afdf4fc3a0742d51b72f6c3a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27e5c782afdf4fc3a0742d51b72f6c3a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27e5c782afdf4fc3a0742d51b72f6c3a"}}, "title": "The Inhibitory Potential of Ferulic Acid Derivatives against the SARS-CoV-2 Main Protease: Molecular Docking, Molecular Dynamics, and ADMET Evaluation.", "authors": [{"family": "Antonopoulou", "given": "Io", "initials": "I", "orcid": "0000-0002-7754-9398", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b07903ae8ac9453ca0e9b1005ab2137e.json"}}, {"family": "Sapountzaki", "given": "Eleftheria", "initials": "E"}, {"family": "Rova", "given": "Ulrika", "initials": "U", "orcid": "0000-0001-7500-2367", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9d7082ee4c84d308472242f35055e9f.json"}}, {"family": "Christakopoulos", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2022-07-25", "journal": {"title": "Biomedicines", "issn": "2227-9059", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "The main protease (Mpro) of SARS-CoV-2 is an appealing target for the development of antiviral compounds, due to its critical role in the viral life cycle and its high conservation among different coronaviruses and the continuously emerging mutants of SARS-CoV-2. Ferulic acid (FA) is a phytochemical with several health benefits that is abundant in plant biomass and has been used as a basis for the enzymatic or chemical synthesis of derivatives with improved properties, including antiviral activity against a range of viruses. This study tested 54 reported FA derivatives for their inhibitory potential against Mpro by in silico simulations. Molecular docking was performed using Autodock Vina, resulting in comparable or better binding affinities for 14 compounds compared to the known inhibitors N3 and GC376. ADMET analysis showed limited bioavailability but significantly improved the solubility for the enzymatically synthesized hits while better bioavailability and druglikeness properties but higher toxicity were observed for the chemically synthesized ones. MD simulations confirmed the stability of the complexes of the most promising compounds with Mpro, highlighting FA rutinoside and compound e27 as the best candidates from each derivative category.", "doi": "10.3390/biomedicines10081787", "pmid": "35892687", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "biomedicines10081787"}, {"db": "pmc", "key": "PMC9329733"}], "notes": [], "created": "2022-08-12T08:34:56.494Z", "modified": "2022-08-12T08:34:56.598Z"}, {"entity": "publication", "iuid": "2803bd89db79418ebbde0e679249a6bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2803bd89db79418ebbde0e679249a6bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2803bd89db79418ebbde0e679249a6bf"}}, "title": "Inflammatory mediators profile in patients hospitalized with COVID-19: A comparative study.", "authors": [{"family": "Tufa", "given": "Abdisa", "initials": "A"}, {"family": "Gebremariam", "given": "Tewodros Haile", "initials": "TH"}, {"family": "Manyazewal", "given": "Tsegahun", "initials": "T"}, {"family": "Getinet", "given": "Tewodros", "initials": "T"}, {"family": "Webb", "given": "Dominic-Luc", "initials": "DL"}, {"family": "Hellstr\u00f6m", "given": "Per M", "initials": "PM"}, {"family": "Genet", "given": "Solomon", "initials": "S"}], "type": "journal article", "published": "2022-07-25", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "13", "pages": "964179", "issn-l": "1664-3224"}, "abstract": "Abnormal inflammatory mediator concentrations during SARS-CoV-2 infection may represent disease severity. We aimed to assess plasma inflammatory mediator concentrations in patients with SARS-CoV-2 in Addis Ababa, Ethiopia. In this study, 260 adults: 126 hospitalized patients with confirmed COVID-19 sorted into severity groups: severe (n=68) and mild or moderate (n=58), and 134 healthy controls were enrolled. We quantified 39 plasma inflammatory mediators using multiplex ELISA. Spearman rank correlation and Mann-Whitney U test were used to identify mechanistically coupled inflammatory mediators and compare disease severity. Compared to healthy controls, patients with COVID-19 had significantly higher levels of interleukins 1\u03b1, 2, 6, 7, 8, 10 and 15, C-reactive protein (CRP), serum amyloid A (SAA), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion protein 1 (VCAM-1), IFN-\u03b3-inducible protein-10 (IP-10, CXCL10), macrophage inflammatory protein-1 alpha (MIP-1\u03b1, CCL3), eotaxin-3 (CCL26), interferon-gamma (IFN-\u03b3), tumor necrosis factor-\u03b1 (TNF-\u03b1), basic fibroblast growth factor (bFGF), placental growth factor (PlGF), and fms-like tyrosine kinase 1 (Flt-1). Patients with severe COVID-19 had higher IL-10 and lower macrophage-derived chemokine (MDC, CCL22) compared to the mild or moderate group (P<0.05). In the receiver operating characteristic curve, SAA, IL-6 and CRP showed strong sensitivity and specificity in predicting the severity and prognosis of COVID-19. Greater age and higher CRP had a significant association with disease severity (P<0.05). Our findings reveal that CRP, SAA, VCAM-1, CXCL10, CCL22 and IL-10 levels are promising biomarkers for COVID-19 disease severity, suggesting that plasma inflammatory mediators could be used as warning indicators of COVID-19 severity, aid in COVID-19 prognosis and treatment.", "doi": "10.3389/fimmu.2022.964179", "pmid": "35958594", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC9359079"}], "notes": [], "created": "2022-08-16T15:40:42.715Z", "modified": "2022-08-16T15:40:48.502Z"}, {"entity": "publication", "iuid": "e423ccc6f6ef417e9c25f79beb912f33", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e423ccc6f6ef417e9c25f79beb912f33.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e423ccc6f6ef417e9c25f79beb912f33"}}, "title": "Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study.", "authors": [{"family": "Izadi", "given": "Zara", "initials": "Z"}, {"family": "Gianfrancesco", "given": "Milena A", "initials": "MA"}, {"family": "Schmajuk", "given": "Gabriela", "initials": "G"}, {"family": "Jacobsohn", "given": "Lindsay", "initials": "L"}, {"family": "Katz", "given": "Patricia", "initials": "P"}, {"family": "Rush", "given": "Stephanie", "initials": "S"}, {"family": "Ja", "given": "Clairissa", "initials": "C"}, {"family": "Taylor", "given": "Tiffany", "initials": "T"}, {"family": "Shidara", "given": "Kie", "initials": "K"}, {"family": "Danila", "given": "Maria I", "initials": "MI"}, {"family": "Wysham", "given": "Katherine D", "initials": "KD"}, {"family": "Strangfeld", "given": "Anja", "initials": "A"}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL"}, {"family": "Gossec", "given": "Laure", "initials": "L"}, {"family": "Carmona", "given": "Loreto", "initials": "L"}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S"}, {"family": "Kearsley-Fleet", "given": "Lianne", "initials": "L"}, {"family": "Schaefer", "given": "Martin", "initials": "M"}, {"family": "Al-Emadi", "given": "Samar", "initials": "S"}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA"}, {"family": "Hsu", "given": "Tiffany Y-T", "initials": "TY"}, {"family": "Patel", "given": "Naomi J", "initials": "NJ"}, {"family": "Wise", "given": "Leanna", "initials": "L"}, {"family": "Gilbert", "given": "Emily", "initials": "E"}, {"family": "Duarte-Garc\u00eda", "given": "Al\u00ed", "initials": "A"}, {"family": "Valenzuela-Almada", "given": "Maria O", "initials": "MO"}, {"family": "Ugarte-Gil", "given": "Manuel F", "initials": "MF"}, {"family": "Ljung", "given": "Lotta", "initials": "L"}, {"family": "Scir\u00e8", "given": "Carlo A", "initials": "CA"}, {"family": "Carrara", "given": "Greta", "initials": "G"}, {"family": "Hachulla", "given": "Eric", "initials": "E"}, {"family": "Richez", "given": "Christophe", "initials": "C"}, {"family": "Cacoub", "given": "Patrice", "initials": "P"}, {"family": "Thomas", "given": "Thierry", "initials": "T"}, {"family": "Santos", "given": "Maria J", "initials": "MJ"}, {"family": "Bernardes", "given": "Miguel", "initials": "M"}, {"family": "Hasseli", "given": "Rebecca", "initials": "R"}, {"family": "Regierer", "given": "Anne", "initials": "A"}, {"family": "Schulze-Koops", "given": "Hendrik", "initials": "H"}, {"family": "M\u00fcller-Ladner", "given": "Ulf", "initials": "U"}, {"family": "Pons-Estel", "given": "Guillermo", "initials": "G"}, {"family": "Tanten", "given": "Romina", "initials": "R"}, {"family": "Nieto", "given": "Romina E", "initials": "RE"}, {"family": "Pisoni", "given": "Cecilia N", "initials": "CN"}, {"family": "Tissera", "given": "Yohana S", "initials": "YS"}, {"family": "Xavier", "given": "Ricardo", "initials": "R"}, {"family": "Lopes Marques", "given": "Claudia D", "initials": "CD"}, {"family": "Pileggi", "given": "Gecilmara C S", "initials": "GCS"}, {"family": "Robinson", "given": "Philip C", "initials": "PC"}, {"family": "Machado", "given": "Pedro M", "initials": "PM"}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS"}, {"family": "Sufka", "given": "Paul", "initials": "P"}, {"family": "Grainger", "given": "Rebecca", "initials": "R"}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Gore-Massy", "given": "Monique", "initials": "M"}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Yazdany", "given": "Jinoos", "initials": "J"}, {"family": "COVID-19 Global Rheumatology Alliance Registry", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-25", "journal": {"title": "Lancet Rheumatol", "issn": "2665-9913", "issn-l": null}, "abstract": "Differences in the distribution of individual-level clinical risk factors across regions do not fully explain the observed global disparities in COVID-19 outcomes. We aimed to investigate the associations between environmental and societal factors and country-level variations in mortality attributed to COVID-19 among people with rheumatic disease globally.\n\nIn this observational study, we derived individual-level data on adults (aged 18-99 years) with rheumatic disease and a confirmed status of their highest COVID-19 severity level from the COVID-19 Global Rheumatology Alliance (GRA) registry, collected between March 12, 2020, and Aug 27, 2021. Environmental and societal factors were obtained from publicly available sources. The primary endpoint was mortality attributed to COVID-19. We used a multivariable logistic regression to evaluate independent associations between environmental and societal factors and death, after controlling for individual-level risk factors. We used a series of nested mixed-effects models to establish whether environmental and societal factors sufficiently explained country-level variations in death.\n\n14 044 patients from 23 countries were included in the analyses. 10 178 (72\u00b75%) individuals were female and 3866 (27\u00b75%) were male, with a mean age of 54\u00b74 years (SD 15\u00b76). Air pollution (odds ratio 1\u00b710 per 10 \u03bcg/m3 [95% CI 1\u00b701-1\u00b717]; p=0\u00b70105), proportion of the population aged 65 years or older (1\u00b719 per 1% increase [1\u00b710-1\u00b730]; p<0\u00b70001), and population mobility (1\u00b703 per 1% increase in number of visits to grocery and pharmacy stores [1\u00b702-1\u00b705]; p<0\u00b70001 and 1\u00b702 per 1% increase in number of visits to workplaces [1\u00b700-1\u00b703]; p=0\u00b7032) were independently associated with higher odds of mortality. Number of hospital beds (0\u00b794 per 1-unit increase per 1000 people [0\u00b788-1\u00b700]; p=0\u00b7046), human development index (0\u00b765 per 0\u00b71-unit increase [0\u00b744-0\u00b796]; p=0\u00b7032), government response stringency (0\u00b783 per 10-unit increase in containment index [0\u00b774-0\u00b793]; p=0\u00b70018), as well as follow-up time (0\u00b778 per month [0\u00b769-0\u00b788]; p<0\u00b70001) were independently associated with lower odds of mortality. These factors sufficiently explained country-level variations in death attributable to COVID-19 (intraclass correlation coefficient 1\u00b72% [0\u00b71-9\u00b75]; p=0\u00b714).\n\nOur findings highlight the importance of environmental and societal factors as potential explanations of the observed regional disparities in COVID-19 outcomes among people with rheumatic disease and lay foundation for a new research agenda to address these disparities.\n\nAmerican College of Rheumatology and European Alliance of Associations for Rheumatology.", "doi": "10.1016/S2665-9913(22)00192-8", "pmid": "35909441", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2665-9913(22)00192-8"}, {"db": "pmc", "key": "PMC9313519"}], "notes": [], "created": "2022-08-11T12:05:46.825Z", "modified": "2022-08-11T12:05:46.841Z"}, {"entity": "publication", "iuid": "1b953f2643e640a9ac8c200626ce9e13", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b953f2643e640a9ac8c200626ce9e13.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b953f2643e640a9ac8c200626ce9e13"}}, "title": "Substantial impact of mobility restrictions on reducing COVID-19 incidence in Italy in 2020.", "authors": [{"family": "Vinceti", "given": "Marco", "initials": "M", "orcid": "0000-0002-0551-2473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a25953d69dcd4b9bb597385be88340bc.json"}}, {"family": "Balboni", "given": "Erica", "initials": "E"}, {"family": "Rothman", "given": "Kenneth J", "initials": "KJ"}, {"family": "Teggi", "given": "Sergio", "initials": "S"}, {"family": "Bellino", "given": "Stefania", "initials": "S"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Ferrari", "given": "Fabrizio", "initials": "F"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}, {"family": "Filippini", "given": "Tommaso", "initials": "T"}], "type": "journal article", "published": "2022-07-24", "journal": {"title": "J Travel Med", "issn": "1708-8305", "issn-l": null}, "abstract": "Italy was the first country after China to be severely affected by the COVID-19 pandemic, in early 2020. The country responded swiftly to the outbreak with a nationwide two-step lockdown, the first one light, and the second one tight. By analysing 2020 national mobile phone movements, we assessed how lockdown compliance influenced its efficacy.\n\nWe measured individual mobility during the first epidemic wave with mobile phone movements tracked through carrier networks, and related this mobility to daily new SARS-CoV-2 infections, hospital admissions, intensive care admissions and deaths attributed to COVID-19, taking into account reason for travel (work-related or not) and the means of transport.\n\nThe tight lockdown resulted in an 82% reduction in mobility for the entire country and was effective in swiftly curbing the outbreak as indicated by a shorter time-to-peak of all health outcomes, particularly for provinces with the highest mobility reductions and the most intense COVID-19 spread. Reduction of work-related mobility was accompanied by a nearly linear benefit in outbreak containment; work-unrelated movements had a similar effect only for restrictions exceeding 50%. Reduction in mobility by car and by airplane was nearly linearly associated with a decrease in most COVID-19 health outcomes, while for train travel reductions exceeding 55% had no additional beneficial effects. The absence of viral variants and vaccine availability during the study period eliminated confounding from these two sources.\n\nAdherence to the COVID-19 tight lockdown during the first wave in Italy was high and effective in curtailing the outbreak. Any work-related mobility reduction was effective, but only high reductions in work-unrelated mobility restrictions were effective. For train travel, there was a threshold above which no further benefit occurred. These findings could be particular to the spread of SARS-CoV-2, but might also apply to other communicable infections with comparable transmission dynamics.", "doi": "10.1093/jtm/taac081", "pmid": "35876268", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6649390"}], "notes": [], "created": "2022-08-12T08:39:30.176Z", "modified": "2022-08-12T08:39:30.205Z"}, {"entity": "publication", "iuid": "f0fae26f35db4e589c037eedb07353a8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f0fae26f35db4e589c037eedb07353a8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f0fae26f35db4e589c037eedb07353a8"}}, "title": "COVID-19 Vaccination In Autoimmune Diseases (COVAD) Study: Vaccine Safety In Idiopathic Inflammatory Myopathies.", "authors": [{"family": "Gil-Vila", "given": "Albert", "initials": "A"}, {"family": "Naveen", "given": "R", "initials": "R"}, {"family": "Selva-O'Callaghan", "given": "Albert", "initials": "A"}, {"family": "Sen", "given": "Parikshit", "initials": "P"}, {"family": "Nune", "given": "Arvind", "initials": "A"}, {"family": "Gaur", "given": "Prithvi Sanjeevkumar", "initials": "PS"}, {"family": "Gonzalez", "given": "Raquel Ar\u00e0nega", "initials": "RA"}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M"}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V"}, {"family": "Kardes", "given": "Sinan", "initials": "S"}, {"family": "Kim", "given": "Minchul", "initials": "M"}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A"}, {"family": "Milchert", "given": "Marcin", "initials": "M"}, {"family": "Gheita", "given": "Tamer", "initials": "T"}, {"family": "Salim", "given": "Babur", "initials": "B"}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T"}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE"}, {"family": "Parodis", "given": "Ioannis", "initials": "I"}, {"family": "Nikiphorou", "given": "Elena", "initials": "E"}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL"}, {"family": "Chatterjee", "given": "Tulika", "initials": "T"}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L"}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA"}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK"}, {"family": "Ziade", "given": "Nelly", "initials": "N"}, {"family": "Knitza", "given": "Johannes", "initials": "J"}, {"family": "Kuwana", "given": "Masataka", "initials": "M"}, {"family": "Distler", "given": "Oliver", "initials": "O"}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V"}, {"family": "Aggarwal", "given": "Rohit", "initials": "R"}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "COVAD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-23", "journal": {"title": "Muscle Nerve", "issn": "1097-4598", "issn-l": null}, "abstract": "We studied COVID-19 vaccination-related adverse events (ADEs) 7-days post-vaccination in patients with idiopathic inflammatory myopathies (IIMs) and other systemic autoimmune and inflammatory disorders (SAIDs).\n\n7-day vaccine ADEs were collected in an international patient self-reported e-survey. Descriptive statistics and multivariable regression were performed.\n\n10,900 respondents [1227 IIMs; 4640 SAIDs; 5033 healthy controls (HCs), median age 42 (IQR 30-55) years, 74% female, 45% Caucasian, 69% completely vaccinated] were analysed. 76.3% IIMs patients reported minor and 4.6% major ADEs. Patients with active IIMs reported more frequent major [OR 2.7 (1.04-7.3)] and minor [OR 1.5 (1.1-2.2)] ADEs than inactive IIMs. Rashes were more frequent in IIMs [OR-2.3(1.2-4.2)] than HCs. ADEs were not impacted by steroid dose, although hydroxychloroquine and intravenous/subcutaneous immunoglobulins were associated with a higher risk of minor ADEs [OR 1.9 (1.1-3.3), OR 2.2 (1.1-4.3)]. Overall, ADEs were less frequent in inclusion body myositis (IBM) and BNT162b2 (Pfizer) vaccine recipients DISCUSSION: 7-day post-vaccination ADEs were comparable in patients with IIMs, SAIDs, and HCs, except for a higher risk of rashes in IIMs. Patients with DM, active disease may be at higher risk, and IBM patients at lower risk of specific ADEs. Overall, the benefit of preventing severe COVID-19 through vaccination likely outweighs the risk of vaccine-related ADEs Our results may inform future guidelines regarding COVID-19 vaccination in patients with SAIDs, and specifically in IIMs. Studies to evaluate long-term outcomes and disease flares are needed to shed more light on developing future COVID-19 vaccination guidelines. This article is protected by copyright. All rights reserved.", "doi": "10.1002/mus.27681", "pmid": "35869701", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9349921"}], "notes": [], "created": "2022-08-12T08:41:00.315Z", "modified": "2022-08-12T08:41:00.388Z"}, {"entity": "publication", "iuid": "4003a925eb2c466f8c22f00f2ea1dbfd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4003a925eb2c466f8c22f00f2ea1dbfd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4003a925eb2c466f8c22f00f2ea1dbfd"}}, "title": "Development of a Prediction Model for COVID-19 Acute Respiratory Distress Syndrome in Patients With Rheumatic Diseases: Results From the Global Rheumatology Alliance Registry.", "authors": [{"family": "Izadi", "given": "Zara", "initials": "Z", "orcid": "0000-0002-1867-0905", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea11c7b8c33a4535bd66a64954de7cd4.json"}}, {"family": "Gianfrancesco", "given": "Milena A", "initials": "MA", "orcid": "0000-0002-8351-4626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dca9cada1314065ab094be6fc17524e.json"}}, {"family": "Aguirre", "given": "Alfredo", "initials": "A", "orcid": "0000-0001-6999-6297", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b39f93f5d6aa452da23107f8608e5304.json"}}, {"family": "Strangfeld", "given": "Anja", "initials": "A"}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL"}, {"family": "Gossec", "given": "Laure", "initials": "L"}, {"family": "Carmona", "given": "Loreto", "initials": "L"}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S", "orcid": "0000-0002-8611-162X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73b17eb08d984421847f733b7a6a49d4.json"}}, {"family": "Kearsley-Fleet", "given": "Lianne", "initials": "L", "orcid": "0000-0003-0377-1575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9cc64aac266462baf67998b3d49c6f7.json"}}, {"family": "Schaefer", "given": "Martin", "initials": "M", "orcid": "0000-0001-6487-3634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb2c617a7902440eb574fcb1141785ac.json"}}, {"family": "Seet", "given": "Andrea M", "initials": "AM"}, {"family": "Schmajuk", "given": "Gabriela", "initials": "G", "orcid": "0000-0003-2687-5043", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9ea497446e44b87b2169bc6c67fbf38.json"}}, {"family": "Jacobsohn", "given": "Lindsay", "initials": "L"}, {"family": "Katz", "given": "Patricia", "initials": "P", "orcid": "0000-0002-8146-2519", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/142b667a5d2c4a6a87af7c4315130d3b.json"}}, {"family": "Rush", "given": "Stephanie", "initials": "S"}, {"family": "Al-Emadi", "given": "Samar", "initials": "S", "orcid": "0000-0001-7942-4831", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49a627d387d042f7b99d821d9676d0d5.json"}}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA", "orcid": "0000-0002-5556-4618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/192552e5e3d2435799e57111ea84502d.json"}}, {"family": "Hsu", "given": "Tiffany Y-T", "initials": "TY"}, {"family": "Patel", "given": "Naomi J", "initials": "NJ"}, {"family": "Wise", "given": "Leanna", "initials": "L", "orcid": "0000-0002-6172-9474", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a7e415e8715491bb9d0409d4b008443.json"}}, {"family": "Gilbert", "given": "Emily", "initials": "E"}, {"family": "Duarte-Garc\u00eda", "given": "Al\u00ed", "initials": "A", "orcid": "0000-0003-1749-5719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77a5555c1b624ba49ee7c729be2aef95.json"}}, {"family": "Valenzuela-Almada", "given": "Maria O", "initials": "MO"}, {"family": "Ugarte-Gil", "given": "Manuel F", "initials": "MF"}, {"family": "Ribeiro", "given": "Sandra L\u00facia Euz\u00e9bio", "initials": "SLE", "orcid": "0000-0002-4777-8659", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2db6a09138844b1690855b8b44af31ec.json"}}, {"family": "de Oliveira Marinho", "given": "Adriana", "initials": "A"}, {"family": "de Azevedo Valadares", "given": "Lilian David", "initials": "LD"}, {"family": "Giuseppe", "given": "Daniela Di", "initials": "DD"}, {"family": "Hasseli", "given": "Rebecca", "initials": "R"}, {"family": "Richter", "given": "Jutta G", "initials": "JG"}, {"family": "Pfeil", "given": "Alexander", "initials": "A", "orcid": "0000-0002-2709-6685", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a810753de5340c189b577ca7e5f5935.json"}}, {"family": "Schmeiser", "given": "Tim", "initials": "T"}, {"family": "Isnardi", "given": "Carolina A", "initials": "CA"}, {"family": "Reyes Torres", "given": "Alvaro A", "initials": "AA"}, {"family": "Alle", "given": "Gelsomina", "initials": "G"}, {"family": "Saurit", "given": "Ver\u00f3nica", "initials": "V"}, {"family": "Zanetti", "given": "Anna", "initials": "A"}, {"family": "Carrara", "given": "Greta", "initials": "G"}, {"family": "Labreuche", "given": "Julien", "initials": "J"}, {"family": "Barnetche", "given": "Thomas", "initials": "T"}, {"family": "Herasse", "given": "Muriel", "initials": "M"}, {"family": "Plassart", "given": "Samira", "initials": "S"}, {"family": "Santos", "given": "Maria Jos\u00e9", "initials": "MJ", "orcid": "0000-0002-7946-1365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d031d58f434247fd83359ee0c7602db5.json"}}, {"family": "Rodrigues", "given": "Ana Maria", "initials": "AM"}, {"family": "Robinson", "given": "Philip C", "initials": "PC", "orcid": "0000-0002-3156-3418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/950b622d31724172817ccde09902d215.json"}}, {"family": "Machado", "given": "Pedro M", "initials": "PM", "orcid": "0000-0002-8411-7972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef40d1eea57946e4a37d2e92a02a47cd.json"}}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS", "orcid": "0000-0003-0786-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d99dc166f48d4af7b8e46dc999c7444b.json"}}, {"family": "Sufka", "given": "Paul", "initials": "P"}, {"family": "Grainger", "given": "Rebecca", "initials": "R", "orcid": "0000-0001-9201-8678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9d304e9e29a43a5a7a76679c002a876.json"}}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Costello", "given": "Wendy", "initials": "W"}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Yazdany", "given": "Jinoos", "initials": "J", "orcid": "0000-0002-3508-4094", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62bbeb3392ce40d482da768af63f5d54.json"}}, {"family": "Global Rheumatology Alliance Registry", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-22", "journal": {"title": "ACR Open Rheumatol", "issn": "2578-5745", "issn-l": null}, "abstract": "Some patients with rheumatic diseases might be at higher risk for coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS). We aimed to develop a prediction model for COVID-19 ARDS in this population and to create a simple risk score calculator for use in clinical settings.\n\nData were derived from the COVID-19 Global Rheumatology Alliance Registry from March 24, 2020, to May 12, 2021. Seven machine learning classifiers were trained on ARDS outcomes using 83 variables obtained at COVID-19 diagnosis. Predictive performance was assessed in a US test set and was validated in patients from four countries with independent registries using area under the curve (AUC), accuracy, sensitivity, and specificity. A simple risk score calculator was developed using a regression model incorporating the most influential predictors from the best performing classifier.\n\nThe study included 8633 patients from 74 countries, of whom 523 (6%) had ARDS. Gradient boosting had the highest mean AUC (0.78; 95% confidence interval [CI]: 0.67-0.88) and was considered the top performing classifier. Ten predictors were identified as key risk factors and were included in a regression model. The regression model that predicted ARDS with 71% (95% CI: 61%-83%) sensitivity in the test set, and with sensitivities ranging from 61% to 80% in countries with independent registries, was used to develop the risk score calculator.\n\nWe were able to predict ARDS with good sensitivity using information readily available at COVID-19 diagnosis. The proposed risk score calculator has the potential to guide risk stratification for treatments, such as monoclonal antibodies, that have potential to reduce COVID-19 disease progression.", "doi": "10.1002/acr2.11481", "pmid": "35869686", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9350083"}], "notes": [], "created": "2022-08-12T08:41:21.838Z", "modified": "2022-08-12T08:41:22.412Z"}, {"entity": "publication", "iuid": "a1d27599cc614d1faeaa0ad9baf77bcf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a1d27599cc614d1faeaa0ad9baf77bcf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a1d27599cc614d1faeaa0ad9baf77bcf"}}, "title": "Nurses' Experiences of Caring for Patients With Suspected or Confirmed COVID-19 in the Initial Stage of the Pandemic.", "authors": [{"family": "Mattsson", "given": "Janet", "initials": "J"}, {"family": "Hedlund", "given": "Elin", "initials": "E"}, {"family": "George-Svahn", "given": "Lisa", "initials": "L"}, {"family": "Scheers-Andersson", "given": "Elina", "initials": "E"}, {"family": "Mazaheri", "given": "Monir", "initials": "M"}, {"family": "Bj\u00f6rling", "given": "Gunilla", "initials": "G", "orcid": "0000-0003-1445-900X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae42c961332e49a3aca05f09c4a70f27.json"}}], "type": "journal article", "published": "2022-07-21", "journal": {"title": "SAGE Open Nurs", "issn": "2377-9608", "volume": "8", "pages": "23779608221114981", "issn-l": null}, "abstract": "Nursing staff have faced various challenges during the global pandemic of COVID-19 such as nursing shortages. The great number of COVID-19 patients requiring hospitalization placed heavy demands on healthcare staff to maintain patient safety and to work according to constantly changing guidelines to prevent the spread of infection.\n\nThe objective was to describe nurses' experiences of caring for patients with suspected or confirmed COVID-19 in the initial phase of the pandemic.\n\nThe study has a qualitative design. Semi-structured interviews were conducted with seven nurses in primary care and hospital care during the initial stage of the pandemic. Qualitative content analysis with an inductive approach was used.\n\nThe nurses expressed that the working routines changed very quickly at the onset of the pandemic. A triage system was implemented to care for patients with symptoms of COVID-19 to prevent transmission between patients. A major change was the constant use of personal protective equipment in patient care. The nurses also experienced a sense of inadequacy regarding the care of the patients and became emotionally affected and exhausted.\n\nThe nurses experienced that many patients worsened clinically, leading to exhausting and difficult nursing care situations. They also experienced increasing responsibility since new protective equipment and procedures needed to be quickly implemented according to frequently changing recommendations, causing the nurses to feel uncertain about how to maintain patient safety. Support from colleagues was crucial to cope throughout the initial stage of the pandemic.", "doi": "10.1177/23779608221114981", "pmid": "35899037", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1177_23779608221114981"}, {"db": "pmc", "key": "PMC9310289"}], "notes": [], "created": "2022-08-12T08:33:56.133Z", "modified": "2022-08-12T08:33:56.186Z"}, {"entity": "publication", "iuid": "a011e37c6ff0437495b432ae29271bdf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a011e37c6ff0437495b432ae29271bdf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a011e37c6ff0437495b432ae29271bdf"}}, "title": "Correction to: Persisting Salivary IgG Against SARS-CoV-2 at 9 Months After Mild COVID-19: A Complementary Approach to Population Surveys.", "authors": [{"family": "Alkharaan", "given": "Hassan", "initials": "H"}, {"family": "Bayati", "given": "Shaghayegh", "initials": "S"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Olsson", "given": "Annika", "initials": "A"}, {"family": "Lindahl", "given": "Karin", "initials": "K"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "Tsilingaridis", "given": "Georgios", "initials": "G"}, {"family": "De Palma", "given": "Patricia", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M", "orcid": "0000-0002-3793-4064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4bc179656eb442f9ac9dc72c8c6841d.json"}}], "type": "published erratum", "published": "2022-07-21", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899"}, "abstract": null, "doi": "10.1093/infdis/jiac121", "pmid": "35859351", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "6647598"}], "notes": [], "created": "2022-08-12T08:42:51.642Z", "modified": "2022-08-12T08:43:07.903Z"}, {"entity": "publication", "iuid": "f1bc151cf7c44c80bb8c06fbbb08d26e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1bc151cf7c44c80bb8c06fbbb08d26e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1bc151cf7c44c80bb8c06fbbb08d26e"}}, "title": "Intrapulmonary Bronchopulmonary Anastomoses in Severe COVID-19-related Acute Respiratory Failure.", "authors": [{"family": "Bodmer", "given": "Jenna", "initials": "J", "orcid": "0000-0003-3110-6679", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4a89b7b5ac7474899be9ef2b0762306.json"}}, {"family": "Levin", "given": "Alice", "initials": "A"}, {"family": "West\u00f6\u00f6", "given": "Christian", "initials": "C"}, {"family": "van der Have", "given": "Oscar", "initials": "O", "orcid": "0000-0003-4726-0697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/120c66dfee0349df981dbe1dff391e8f.json"}}, {"family": "Peruzzi", "given": "Niccol\u00f2", "initials": "N"}, {"family": "Tran-Lundmark", "given": "Karin", "initials": "K"}, {"family": "Abman", "given": "Steven H", "initials": "SH", "orcid": "0000-0002-7292-2085", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/236683b5bd3f4cc6ad63453734a23185.json"}}, {"family": "Galambos", "given": "Csaba", "initials": "C"}], "type": "journal article", "published": "2022-07-20", "journal": {"title": "Am J Respir Crit Care Med", "issn": "1535-4970", "issn-l": "1073-449X"}, "abstract": null, "doi": "10.1164/rccm.202205-0922LE", "pmid": "35857856", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2022-08-12T08:46:06.359Z", "modified": "2022-08-12T08:46:36.162Z"}, {"entity": "publication", "iuid": "236664e051fe44f2a7a3daf4b7131667", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/236664e051fe44f2a7a3daf4b7131667.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/236664e051fe44f2a7a3daf4b7131667"}}, "title": "Compliance with Health Recommendations and Vaccine Hesitancy During the COVID Pandemic in Nine Countries.", "authors": [{"family": "Lansford", "given": "Jennifer E", "initials": "JE", "orcid": "0000-0003-1956-4917", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/099f957450e743acab538878cc487a27.json"}}, {"family": "Rothenberg", "given": "W Andrew", "initials": "WA"}, {"family": "Yotanyamaneewong", "given": "Saengduean", "initials": "S"}, {"family": "Alampay", "given": "Liane Pe\u00f1a", "initials": "LP"}, {"family": "Al-Hassan", "given": "Suha M", "initials": "SM"}, {"family": "Bacchini", "given": "Dario", "initials": "D"}, {"family": "Bornstein", "given": "Marc H", "initials": "MH"}, {"family": "Chang", "given": "Lei", "initials": "L"}, {"family": "Deater-Deckard", "given": "Kirby", "initials": "K"}, {"family": "Di Giunta", "given": "Laura", "initials": "L"}, {"family": "Dodge", "given": "Kenneth A", "initials": "KA"}, {"family": "Gurdal", "given": "Sevtap", "initials": "S"}, {"family": "Liu", "given": "Qin", "initials": "Q"}, {"family": "Long", "given": "Qian", "initials": "Q"}, {"family": "Morgenstern", "given": "Glen", "initials": "G"}, {"family": "Oburu", "given": "Paul", "initials": "P"}, {"family": "Pastorelli", "given": "Concetta", "initials": "C"}, {"family": "Skinner", "given": "Ann T", "initials": "AT"}, {"family": "Sorbring", "given": "Emma", "initials": "E"}, {"family": "Tapanya", "given": "Sombat", "initials": "S"}, {"family": "Steinberg", "given": "Laurence", "initials": "L"}, {"family": "Uribe Tirado", "given": "Liliana Maria", "initials": "LM"}], "type": "journal article", "published": "2022-07-20", "journal": {"title": "Prev Sci", "issn": "1573-6695", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Longitudinal data from the Parenting Across Cultures study of children, mothers, and fathers in 12 cultural groups in nine countries (China, Colombia, Italy, Jordan, Kenya, the Philippines, Sweden, Thailand, and the USA; N = 1331 families) were used to understand predictors of compliance with COVID-19 mitigation strategies and vaccine hesitancy. Confidence in government responses to the COVID pandemic was also examined as a potential moderator of links between pre-COVID risk factors and compliance with COVID mitigation strategies and vaccine hesitancy. Greater confidence in government responses to the COVID pandemic was associated with greater compliance with COVID mitigation strategies and less vaccine hesitancy across cultures and reporters. Pre-COVID financial strain and family stress were less consistent predictors of compliance with COVID mitigation strategies and vaccine hesitancy than confidence in government responses to the pandemic. Findings suggest the importance of bolstering confidence in government responses to future human ecosystem disruptions, perhaps through consistent, clear, non-partisan messaging and transparency in acknowledging limitations and admitting mistakes to inspire compliance with government and public health recommendations.", "doi": "10.1007/s11121-022-01399-9", "pmid": "35857257", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11121-022-01399-9"}], "notes": [], "created": "2022-08-12T08:46:57.085Z", "modified": "2022-08-12T08:47:32.154Z"}, {"entity": "publication", "iuid": "6dcf04f2676e49fcb47b08767d4c064a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6dcf04f2676e49fcb47b08767d4c064a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6dcf04f2676e49fcb47b08767d4c064a"}}, "title": "\"The New Educational Project TELEVASCULAR GAMES During COVID-19 Pandemic.\"", "authors": [{"family": "Chisci", "given": "Emiliano", "initials": "E"}, {"family": "Parlani", "given": "Gianbattista", "initials": "G"}, {"family": "Gatta", "given": "Emanuele", "initials": "E"}, {"family": "Isernia", "given": "Giacomo", "initials": "G"}, {"family": "de Donato", "given": "Gianmarco", "initials": "G"}, {"family": "Antonello", "given": "Michele", "initials": "M"}, {"family": "Simonte", "given": "Gioele", "initials": "G"}, {"family": "K\u00f6lbel", "given": "Tilo", "initials": "T"}, {"family": "Bertoglio", "given": "Luca", "initials": "L"}, {"family": "Yeung", "given": "Kak Khee", "initials": "KK"}, {"family": "Donas", "given": "Konstantinos", "initials": "K"}, {"family": "Fazzini", "given": "Stefano", "initials": "S"}, {"family": "Dias", "given": "Nuno", "initials": "N"}, {"family": "Michelagnoli", "given": "Stefano", "initials": "S"}, {"family": "Televascolare Games Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-20", "journal": {"title": "J Vasc Surg Cases Innov Tech", "issn": "2468-4287", "issn-l": null}, "abstract": "To report methodology and first-year results of a new educational project called \"Televascular Games\", which took place during COVID-19 pandemic.\n\nComplex aneurysmal aortic disease was discussed during a 2-hour competition webinar, according to three modalities. 1) Planning case competition (PCC): 2-4 pre-operative Computed Tomography Angiography (CTA) scans of an already performed selected case were submitted for the competition. CTA-scans were anonymously uploaded, without any reference to the center or the surgeon who performed the case. The competitor had to prepare a presentation of how he/she would have diagnosed, sized, planned, treated and followed up the case, of the medical therapy and of the bail-out maneuvers. 2) Challenging case competition (CCC): the competitor elaborates a presentation of an already treated case concerning an aortic topic and discusses sizing, planning, treatment, possible bail-out maneuvers and obtained results. For the CCC and PCC, the competitors with the best score were pre-selected to present and discuss their plan during the webinars. 3) Quiz competition (QZ): 2-6 angio-CTA scans of already performed selected aortic cases were submitted for the competition. A quiz with multiple-choice questions was answered by the competitors. The top four competitors were selected for the webinars and then they discussed the cases during the webinar. Finally, at the end of the case-discussion, the effective case resolution and follow-up were shown. A final winner was voted via televoting, based on six pre-established criteria. The project was endorsed by different National and International Societies.\n\nBetween October-2020 and December-2021, there were 12 Italian and 1 international webinars with overall 1695 participants (mean 130, range:86-177). Competitors were 54 (mean age 27, range 22-38 years). Two editions were CCCs, two QZs, and nine PCCs. The reliability of the inter-observer sizing of competitors was k=.43 and k=.62 for the proximal and distal sealing measurements respectively and very good (k =.88-.95) in the evaluation of orientation of the vessels, presence of angulations, calcifications and thrombus. The sizing discrepancy resulted in a significant variability of the planning (k=.45). The project ranked 9.6 in a \"10-point\" rating scale by all the participants and competitors.\n\nThe formula of gaming and collegial discussion of aortic cases herein reported has proved valid and attractive during COVID-19 pandemic period. The variability of the results on sizing and planning suggested to confer with a second opinion especially for less experienced surgeons.", "doi": "10.1016/j.jvscit.2022.05.019", "pmid": "35873717", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2468-4287(22)00109-5"}, {"db": "pmc", "key": "PMC9296369"}], "notes": [], "created": "2022-08-12T08:40:33.491Z", "modified": "2022-08-12T08:40:33.519Z"}, {"entity": "publication", "iuid": "5c00b8b46bf74290a4762e8d234a03c1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c00b8b46bf74290a4762e8d234a03c1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c00b8b46bf74290a4762e8d234a03c1"}}, "title": "Methodological guidance for incorporating equity when informing rapid-policy and guideline development.", "authors": [{"family": "Dewidar", "given": "Omar", "initials": "O"}, {"family": "Kawala", "given": "Brenda Allen", "initials": "BA"}, {"family": "Antequera", "given": "Alba", "initials": "A"}, {"family": "Tricco", "given": "Andrea C", "initials": "AC"}, {"family": "Tovey", "given": "David", "initials": "D"}, {"family": "Straus", "given": "Sharon", "initials": "S"}, {"family": "Glover", "given": "Rebecca", "initials": "R"}, {"family": "Tufte", "given": "Janice", "initials": "J"}, {"family": "Magwood", "given": "Olivia", "initials": "O"}, {"family": "Smith", "given": "Maureen", "initials": "M"}, {"family": "Ooi", "given": "Cheow Peng", "initials": "CP"}, {"family": "Dion", "given": "Anna", "initials": "A"}, {"family": "Goetghebeur", "given": "Mireille", "initials": "M"}, {"family": "Reveiz", "given": "Ludovic", "initials": "L"}, {"family": "Negrini", "given": "Stefano", "initials": "S"}, {"family": "Tugwell", "given": "Peter", "initials": "P"}, {"family": "Petkovic", "given": "Jennifer", "initials": "J"}, {"family": "Welch", "given": "Vivian", "initials": "V"}, {"family": "COVID-END Equity Task Force", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-19", "journal": {"title": "J Clin Epidemiol", "issn": "1878-5921", "issn-l": null, "volume": "150", "issue": null, "pages": "142-153"}, "abstract": "We provide guidance for considering equity in rapid reviews through examples of published COVID-19 rapid reviews.\r\n\r\nThis guidance was developed based on a series of methodological meetings, review of internationally renowned guidance such as the Cochrane Handbook and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis for equity-focused systematic reviews (PRISMA-Equity) guideline. We identified Exemplar rapid reviews by searching COVID-19 databases and requesting examples from our team.\r\n\r\nWe proposed the following key steps: 1. involve relevant stakeholders with lived experience in the conduct and design of the review; 2. reflect on equity, inclusion and privilege in team values and composition; 3. develop research question to assess health inequities; 4. conduct searches in relevant disciplinary databases; 5. collect data and critically appraise recruitment, retention and attrition for populations experiencing inequities; 6. analyse evidence on equity; 7. evaluate the applicability of findings to populations experiencing inequities; and 8. adhere to reporting guidelines for communicating review findings. We illustrated these methods through rapid review examples.\r\n\r\nImplementing this guidance could contribute to improving equity considerations in rapid reviews produced in public health emergencies, and help policymakers better understand the distributional impact of diseases on the population.", "doi": "10.1016/j.jclinepi.2022.07.007", "pmid": "35863618", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0895-4356(22)00180-9"}, {"db": "pmc", "key": "PMC9359903"}], "notes": [], "created": "2022-08-12T08:42:08.653Z", "modified": "2022-11-09T08:37:56.301Z"}, {"entity": "publication", "iuid": "1d5ba17b4bf44ac89c3e293f7263ad7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d5ba17b4bf44ac89c3e293f7263ad7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d5ba17b4bf44ac89c3e293f7263ad7a"}}, "title": "Mental health in individuals with self-reported psychiatric symptoms during the COVID-19 pandemic: Baseline data from a swedish longitudinal cohort study.", "authors": [{"family": "Rozental", "given": "Alexander", "initials": "A"}, {"family": "S\u00f6rman", "given": "Karolina", "initials": "K"}, {"family": "Ojala", "given": "Olivia", "initials": "O"}, {"family": "Jangard", "given": "Simon", "initials": "S"}, {"family": "El Alaoui", "given": "Samir", "initials": "S"}, {"family": "M\u00e5nsson", "given": "Kristoffer N T", "initials": "KNT"}, {"family": "Shahnavaz", "given": "Shervin", "initials": "S"}, {"family": "Lundin", "given": "Johan", "initials": "J"}, {"family": "Forsstr\u00f6m", "given": "David", "initials": "D"}, {"family": "Hedman-Lagerl\u00f6f", "given": "Maria", "initials": "M"}, {"family": "Lundgren", "given": "Tobias", "initials": "T"}, {"family": "Jayaram-Lindstr\u00f6m", "given": "Nitya", "initials": "N"}], "type": "journal article", "published": "2022-07-19", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "13", "pages": "933858", "issn-l": "1664-0640"}, "abstract": "Individuals with psychiatric disorders may be both vulnerable and sensitive to rapid societal changes that have occurred during the COVID-19 pandemic. To fully understand these impacts, repeated measurements of these individuals are warranted. The current longitudinal study set out to perform monthly assessment of individuals with common psychiatric disorders using established questionnaires with a possibility for them to self- rate their symptoms, over time.\n\nRecruitment of individuals who identified themselves as struggling with mental health problems, living in Sweden between July 2020 and June 2021 using an online survey. The individuals answered questions on demographics, psychiatric history, current psychiatric symptoms (e.g., Patient Health Questionnaire, PHQ-9; General Anxiety Disorder, GAD-7), somatic health, health-care contacts and any changes therein during the pandemic. Monthly, longitudinal assessments are still ongoing (consenting participants provide data for 1 year), and here we present descriptive statistics from the baseline measurement. All measurements from baseline (>400 items), and follow-ups are presented in detail.\n\nA total of 6.095 participants (average age 35 years) submitted complete baseline data. Marital status (43% single) and number of years of education (48% highest degree being high school) were evenly distributed in this population. The most common lifetime psychiatric disorder in the sample was depressive disorder (80.5%) and generalized anxiety disorder (45.9%), with a substantial proportion having severe symptoms of depression. (30.5%) and anxiety (37.1%). Lifetime suicidal ideation (75.0%) and non-suicidal self-harm (57.7%) were prevalent in the group and 14.5% reported drug use during the pandemic. Allergies (36.8%) were the most common somatic condition, followed by irritable bowel syndrome (18.7%). For those having experienced a traumatic event, 39% showed symptoms during the pandemic indicating PTSD. Regarding contact with mental health services during the pandemic, 22% had established a new contact, and 20% reported to have increased their psychiatric medication compared to before the pandemic.\n\nBaseline data collected during the pandemic from individuals in Sweden with pre-existing psychiatric disorders demonstrate that this sample represents a population suitable for an investigation on the long-term impact of the pandemic, as intended by the longitudinal investigation that is ongoing. Follow-up questionnaires over a 12-month period are being collected and will indicate how the health and well-being of this population was impacted during the changes and uncertainties that have been characteristic of the past 2 years.", "doi": "10.3389/fpsyt.2022.933858", "pmid": "35928773", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9343700"}], "notes": [], "created": "2022-08-11T11:59:59.748Z", "modified": "2022-08-11T11:59:59.764Z"}, {"entity": "publication", "iuid": "810ac4db03734d8891c68503f07daaf2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/810ac4db03734d8891c68503f07daaf2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/810ac4db03734d8891c68503f07daaf2"}}, "title": "Abrupt decreases in infectivity of SARS-CoV-2 in aerosols.", "authors": [{"family": "L\u00f6ndahl", "given": "Jakob", "initials": "J", "orcid": "0000-0001-9379-592X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7648041474a8469aa54218ca177e4c19.json"}}, {"family": "Alsved", "given": "Malin", "initials": "M"}], "type": "journal article", "published": "2022-07-19", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "119", "issue": "29", "pages": "e2208742119", "issn-l": "0027-8424"}, "abstract": null, "doi": "10.1073/pnas.2208742119", "pmid": "35858364", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9304013"}], "notes": [], "created": "2022-08-12T08:45:44.880Z", "modified": "2022-08-12T08:45:44.931Z"}, {"entity": "publication", "iuid": "733f8a5c26e7460db9284901482c7bd9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/733f8a5c26e7460db9284901482c7bd9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/733f8a5c26e7460db9284901482c7bd9"}}, "title": "The effect of herd immunity thresholds on willingness to vaccinate.", "authors": [{"family": "Andersson", "given": "Per A", "initials": "PA", "orcid": "0000-0001-7445-2008", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1fa117de5f540b7a5f13f97803c46b3.json"}}, {"family": "Tingh\u00f6g", "given": "Gustav", "initials": "G", "orcid": "0000-0002-8159-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c4dcebfe7b0425182298cf35259223c.json"}}, {"family": "V\u00e4stfj\u00e4ll", "given": "Daniel", "initials": "D", "orcid": "0000-0003-2873-4500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebf69c8715ab4141a7b06a20d94ca666.json"}}], "type": "journal article", "published": "2022-07-18", "journal": {"title": "Humanit Soc Sci Commun", "issn": "2662-9992", "volume": "9", "issue": "1", "pages": "243", "issn-l": null}, "abstract": "Throughout the COVID-19 pandemic, media and policymakers openly speculated about the number of immune citizens needed to reach a herd immunity threshold. What are the effects of such numerical goals on the willingness to vaccinate? In a large representative sample (N = 1540) of unvaccinated Swedish citizens, we find that giving a low (60%) compared to a high (90%) threshold has direct effects on beliefs about reaching herd immunity and beliefs about how many others that will get vaccinated. Presenting the high threshold makes people believe that herd immunity is harder to reach (on average about half a step on a seven-point scale), compared to the low threshold. Yet at the same time, people also believe that a higher number of the population will get vaccinated (on average about 3.3% more of the population). Since these beliefs affect willingness to vaccinate in opposite directions, some individuals are encouraged and others discouraged depending on the threshold presented. Specifically, in mediation analysis, the high threshold indirectly increases vaccination willingness through the belief that many others will get vaccinated (B = 0.027, p = 0.003). At the same time, the high threshold also decreases vaccination willingness through the belief that the threshold goal is less attainable (B = -0.053, p < 0.001) compared to the low threshold condition. This has consequences for ongoing COVID-19 vaccination and future vaccination campaigns. One message may not fit all, as different groups can be encouraged or discouraged from vaccination.", "doi": "10.1057/s41599-022-01257-7", "pmid": "35874284", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "1257"}, {"db": "pmc", "key": "PMC9294790"}], "notes": [], "created": "2022-08-12T08:40:09.826Z", "modified": "2022-08-12T08:40:09.921Z"}, {"entity": "publication", "iuid": "d7be028906b54732b7f52b626b93497c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d7be028906b54732b7f52b626b93497c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d7be028906b54732b7f52b626b93497c"}}, "title": "Following a healthy/balanced diet predicts lower anxiety and depression during the COVID-19 pandemic.", "authors": [{"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Fortea", "given": "Lydia", "initials": "L"}, {"family": "Pomarol-Clotet", "given": "Edith", "initials": "E"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Fullana", "given": "Miquel \u00c0ngel", "initials": "M\u00c0"}, {"family": "Solanes", "given": "Aleix", "initials": "A"}], "type": "case reports", "published": "2022-07-16", "journal": {"title": "Rev Psiquiatr Salud Ment (Engl Ed)", "issn": "2173-5050", "volume": "15", "issue": "2", "pages": "147-149", "issn-l": null}, "abstract": null, "doi": "10.1016/j.rpsmen.2022.07.003", "pmid": "35840282", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2173-5050(22)00027-9"}, {"db": "pmc", "key": "PMC9274263"}], "notes": [], "created": "2022-08-12T08:55:27.745Z", "modified": "2022-08-12T08:55:27.771Z"}, {"entity": "publication", "iuid": "2679a2dabc50490c856836088dddbab2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2679a2dabc50490c856836088dddbab2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2679a2dabc50490c856836088dddbab2"}}, "title": "Updated SIOG COVID-19 working group recommendations on COVID-19 vaccination among older adults with cancer.", "authors": [{"family": "Soto-Perez-de-Celis", "given": "Enrique", "initials": "E"}, {"family": "Mislang", "given": "Anna Rachelle", "initials": "AR"}, {"family": "Hern\u00e1ndez-Favela", "given": "Celia Gabriela", "initials": "CG"}, {"family": "Russo", "given": "Chiara", "initials": "C"}, {"family": "Colloca", "given": "Giuseppe", "initials": "G"}, {"family": "Williams", "given": "Grant R", "initials": "GR"}, {"family": "O'Hanlon", "given": "Shane", "initials": "S"}, {"family": "Cooper", "given": "Lisa", "initials": "L"}, {"family": "O'Donovan", "given": "Anita", "initials": "A"}, {"family": "Audisio", "given": "Riccardo A", "initials": "RA"}, {"family": "Cheung", "given": "Kwok-Leung", "initials": "KL"}, {"family": "Giron\u00e9s-Sarri\u00f3", "given": "Regina", "initials": "R"}, {"family": "Stauder", "given": "Reinhard", "initials": "R"}, {"family": "Jaklitsch", "given": "Michael", "initials": "M"}, {"family": "Cairo", "given": "Clarito", "initials": "C"}, {"family": "Gil", "given": "Luiz Antonio", "initials": "LA"}, {"family": "Alam", "given": "Mahmood", "initials": "M"}, {"family": "Sattar", "given": "Schroder", "initials": "S"}, {"family": "Kantilal", "given": "Kumud", "initials": "K"}, {"family": "Loh", "given": "Kah Poh", "initials": "KP"}, {"family": "Lichtman", "given": "Stuart M", "initials": "SM"}, {"family": "Brain", "given": "Etienne", "initials": "E"}, {"family": "Wildiers", "given": "Hans", "initials": "H"}, {"family": "Kanesvaran", "given": "Ravindran", "initials": "R"}, {"family": "Battisti", "given": "Nicol\u00f2 Matteo Luca", "initials": "NML"}], "type": "journal article", "published": "2022-07-15", "journal": {"title": "J Geriatr Oncol", "issn": "1879-4076", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jgo.2022.07.005", "pmid": "35853816", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1879-4068(22)00171-0"}, {"db": "pmc", "key": "PMC9283597"}], "notes": [], "created": "2022-08-12T08:49:28.874Z", "modified": "2022-08-12T08:49:28.879Z"}, {"entity": "publication", "iuid": "af44170e42fc454098218a59502ac0ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/af44170e42fc454098218a59502ac0ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/af44170e42fc454098218a59502ac0ef"}}, "title": "Oral manifestations in young adults infected with COVID-19 and impact of smoking: a multi-country cross-sectional study.", "authors": [{"family": "El Tantawi", "given": "Maha", "initials": "M", "orcid": "0000-0003-4989-6584", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b0b3508a71b54068bbfd0a3362541960.json"}}, {"family": "Sabbagh", "given": "Heba Jafar", "initials": "HJ"}, {"family": "Alkhateeb", "given": "Nada Abubakor", "initials": "NA"}, {"family": "Quritum", "given": "Maryam", "initials": "M"}, {"family": "Abourdan", "given": "Joud", "initials": "J"}, {"family": "Qureshi", "given": "Nafeesa", "initials": "N"}, {"family": "Qureshi", "given": "Shabnum", "initials": "S"}, {"family": "Hamoud", "given": "Ahmed", "initials": "A"}, {"family": "Mahmoud", "given": "Nada", "initials": "N"}, {"family": "Odeh", "given": "Ruba", "initials": "R"}, {"family": "Al-Khanati", "given": "Nuraldeen Maher", "initials": "NM"}, {"family": "Jaber", "given": "Rawiah", "initials": "R"}, {"family": "Balkhoyor", "given": "Abdulrahman Loaie", "initials": "AL"}, {"family": "Shabi", "given": "Mohammed", "initials": "M"}, {"family": "Folayan", "given": "Morenike O", "initials": "MO", "orcid": "0000-0002-9008-7730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f05ff9524108435d8c181463693f988e.json"}}, {"family": "Gomaa", "given": "Noha", "initials": "N"}, {"family": "Al Nahdi", "given": "Raqiya", "initials": "R"}, {"family": "Mahmoud", "given": "Nawal", "initials": "N"}, {"family": "El Wazziki", "given": "Hanane", "initials": "H"}, {"family": "Alnaas", "given": "Manal", "initials": "M"}, {"family": "Samodien", "given": "Bahia", "initials": "B"}, {"family": "Mahmoud", "given": "Rawa", "initials": "R"}, {"family": "Abu Assab", "given": "Nour", "initials": "N"}, {"family": "Saad", "given": "Sherin", "initials": "S"}, {"family": "Al-Hachim", "given": "Sondos", "initials": "S"}, {"family": "Alshaikh", "given": "Ali", "initials": "A"}, {"family": "Abdelaziz", "given": "Wafaa", "initials": "W"}], "type": "journal article", "published": "2022-07-15", "journal": {"title": "PeerJ", "issn": "2167-8359", "volume": "10", "pages": "e13555", "issn-l": "2167-8359"}, "abstract": "Oral manifestations and lesions could adversely impact the quality of people's lives. COVID-19 infection may interact with smoking and the impact on oral manifestations is yet to be discovered.\n\nThe aim of this study was to assess the self-reported presence of oral lesions by COVID-19-infected young adults and the differences in the association between oral lesions and COVID-19 infection in smokers and non-smokers.\n\nThis cross-sectional multi-country study recruited 18-to-23-year-old adults. A validated questionnaire was used to collect data on COVID-19-infection status, smoking and the presence of oral lesions (dry mouth, change in taste, and others) using an online platform. Multi-level logistic regression was used to assess the associations between the oral lesions and COVID-19 infection; the modifying effect of smoking on the associations.\n\nData was available from 5,342 respondents from 43 countries. Of these, 8.1% reported COVID-19-infection, 42.7% had oral manifestations and 12.3% were smokers. A significantly greater percentage of participants with COVID-19-infection reported dry mouth and change in taste than non-infected participants. Dry mouth (AOR=, 9=xxx) and changed taste (AOR=, 9=xxx) were associated with COVID-19- infection. The association between COVID-19-infection and dry mouth was stronger among smokers than non-smokers (AOR = 1.26 and 1.03, p = 0.09) while the association with change in taste was stronger among non-smokers (AOR = 1.22 and 1.13, p = 0.86).\n\nDry mouth and changed taste may be used as an indicator for COVID-19 infection in low COVID-19-testing environments. Smoking may modify the association between some oral lesions and COVID-19-infection.", "doi": "10.7717/peerj.13555", "pmid": "35860046", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "13555"}, {"db": "pmc", "key": "PMC9291069"}], "notes": [], "created": "2022-08-12T08:42:26.739Z", "modified": "2022-08-12T08:42:26.838Z"}, {"entity": "publication", "iuid": "0d9ee7903d15472dba9fe4a6d94c737d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d9ee7903d15472dba9fe4a6d94c737d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d9ee7903d15472dba9fe4a6d94c737d"}}, "title": "Immigrant background and socioeconomic status are associated with severe COVID-19 requiring intensive care.", "authors": [{"family": "Nordberg", "given": "Per", "initials": "P"}, {"family": "Jonsson", "given": "Martin", "initials": "M"}, {"family": "Hollenberg", "given": "Jacob", "initials": "J"}, {"family": "Ringh", "given": "Mattias", "initials": "M"}, {"family": "Kiiski Berggren", "given": "Ritva", "initials": "R"}, {"family": "Hofmann", "given": "Robin", "initials": "R"}, {"family": "Svensson", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2022-07-15", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "12133", "issn-l": "2045-2322"}, "abstract": "To determine whether immigrant background and socioeconomic status were associated with increased risk to develop severe Coronavirus disease 2019 (COVID-19) requiring mechanical ventilation at the intensive care unit and to study their effects on 90-day mortality. Nationwide case-control study with personal-level data from the Swedish Intensive Care register linked with socioeconomic data from Statistics Sweden and comorbidity data from the national patient register. For each case of COVID-19 treated with mechanical ventilation at the intensive care unit (outcome), 10 population controls were matched for age, sex and area of residence. Logistic and Cox regression were used to study the association between the exposure (immigrant background, income and educational level) and 90-day mortality. In total, 4 921 cases and 49 210 controls were matched. In the adjusted model, the risk of severe COVID-19 was highest in individuals born in Asia (Odds ratio [OR] = 2.44, 95% confidence interval [CI] = 2.20-2.69), South America (OR = 2.34, 95% CI = 1.82-2.98) and Africa (OR = 2.11, 95% CI = 1.76-2.50). Post-secondary education was associated with a lower risk of severe COVID-19 (OR = 0.75, CI = 0.69-0.82) as was the highest (vs. lowest) income quintile (OR = 0.87, CI = 0.77-0.97). In the fully adjusted Cox-regression analysis birth region of Africa (OR 1.38, CI = 1.03-1.86) and high income (OR 0.75, CI 0.63-0.89) were associated with 90-day mortality. Immigrant background, educational level and income were independently associated with acquiring severe COVID-19 with need for mechanical ventilation.", "doi": "10.1038/s41598-022-15884-2", "pmid": "35840691", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-15884-2"}, {"db": "pmc", "key": "PMC9285186"}], "notes": [], "created": "2022-08-12T08:55:10.836Z", "modified": "2022-08-12T08:55:10.842Z"}, {"entity": "publication", "iuid": "dda4e2f7fa5a492b99c23d4aa742a141", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dda4e2f7fa5a492b99c23d4aa742a141.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dda4e2f7fa5a492b99c23d4aa742a141"}}, "title": "Correction: Evaluation of science advice during the COVID-19 pandemic in Sweden.", "authors": [{"family": "Brusselaers", "given": "Nele", "initials": "N", "orcid": "0000-0003-0137-447X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8a4e9c84a5843c18e95fe0becb19506.json"}}, {"family": "Steadson", "given": "David", "initials": "D", "orcid": "0000-0003-3063-3880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce74e24664974b86943dcc03ba277cd4.json"}}, {"family": "Bjorklund", "given": "Kelly", "initials": "K"}, {"family": "Breland", "given": "Sofia", "initials": "S"}, {"family": "Stilhoff S\u00f6rensen", "given": "Jens", "initials": "J"}, {"family": "Ewing", "given": "Andrew", "initials": "A"}, {"family": "Bergmann", "given": "Sigurd", "initials": "S"}, {"family": "Steineck", "given": "Gunnar", "initials": "G"}], "type": "published erratum", "published": "2022-07-15", "journal": {"title": "Humanit Soc Sci Commun", "issn": "2662-9992", "volume": "9", "issue": "1", "pages": "239", "issn-l": null}, "abstract": "[This corrects the article DOI: 10.1057/s41599-022-01097-5.].", "doi": "10.1057/s41599-022-01254-w", "pmid": "35856700", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "1254"}, {"db": "pmc", "key": "PMC9284503"}], "notes": [], "created": "2022-08-12T08:47:40.670Z", "modified": "2022-08-12T08:47:50.453Z"}, {"entity": "publication", "iuid": "a8ba104875974e309f4d9950c3d67514", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8ba104875974e309f4d9950c3d67514.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8ba104875974e309f4d9950c3d67514"}}, "title": "Cognitive Behavioral Therapy and Acceptance and Commitment Therapy (CBT-ACT) vs. Standard Care After Critical Illness Due to COVID-19: Protocol for a Pilot Randomized Controlled Trial.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Lidin-Darlington", "given": "Pernilla", "initials": "P"}, {"family": "Lilja", "given": "Gisela", "initials": "G"}, {"family": "Nilsson", "given": "Anna", "initials": "A"}, {"family": "Schandl", "given": "Anna", "initials": "A"}, {"family": "Friberg", "given": "Hans", "initials": "H"}], "type": "journal article", "published": "2022-07-15", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "13", "pages": "907215", "issn-l": "1664-0640"}, "abstract": "Post-covid syndrome is an emerging condition involving a wide range of symptoms, including high rates of poor mental health. The diagnostic relevance and clinical severity of these symptoms are largely unknown, and evidence for treatment of post-covid mental health symptoms is lacking. This protocol describes a pilot randomized clinical trial, primarily aiming to assess feasibility, participant adherence and satisfaction in a novel phycho-therapeutic intervention on post-covid anxiety and depression symptoms \u22651 year after critically ill COVID-19. Whether the intervention may generate improvements in post-covid depression, anxiety, post-traumatic stress and health-related quality of life (HRQoL) will be addressed in a following larger trial.\n\nA multicenter, investigator-initiated randomized controlled trial (Clinical Trial Identifier number NCT05119608) including Intensive Care Unit (ICU)-treated COVID-19 survivors, who display symptoms of anxiety and/or depression at follow-up 12 months after hospitalization (Hospital Anxiety and Depression Scale \u22658 for depression or anxiety). Eligible individuals are referred to a psychiatrist for structured diagnostic assessment and inclusion in the trial. Participants will be randomized to either a 10-week cognitive behavioral therapy intervention with added acceptance and commitment therapy (CBT-ACT) or standard care (primary care referral). Primary study outcome measure is feasibility and patient adherence, defined as the proportion of participants who consent to randomization and remain in the study including follow-up. Secondary outcome measures include reduced symptoms in the HADS depression/anxiety subscales, post-traumatic symptoms, HRQoL and user satisfaction at 3 months after the intervention.\n\nThis protocol describes a pilot trial to assess feasibility and preliminary effects of a structured psycho-therapeutic intervention to ameliorate mental health in a population severely affected by COVID-19, where evidence for structured psycho-therapy is lacking.", "doi": "10.3389/fpsyt.2022.907215", "pmid": "35911237", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9334556"}], "notes": [], "created": "2022-08-11T12:04:49.893Z", "modified": "2022-08-11T12:04:49.909Z"}, {"entity": "publication", "iuid": "492bb62d87bc4d089a0e222326142c51", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/492bb62d87bc4d089a0e222326142c51.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/492bb62d87bc4d089a0e222326142c51"}}, "title": "Changes in food-related costs during the COVID-19 pandemic among families managing food allergy.", "authors": [{"family": "Golding", "given": "Michael A", "initials": "MA"}, {"family": "Lemoine-Courcelles", "given": "Cath\u00e9rine", "initials": "C"}, {"family": "Abrams", "given": "Elissa M", "initials": "EM"}, {"family": "Ben-Shoshan", "given": "Moshe", "initials": "M"}, {"family": "B\u00e9gin", "given": "Philippe", "initials": "P"}, {"family": "Chan", "given": "Edmond S", "initials": "ES"}, {"family": "Chu", "given": "Derek K", "initials": "DK"}, {"family": "Gerdts", "given": "Jennifer D", "initials": "JD"}, {"family": "Povolo", "given": "Beatrice", "initials": "B"}, {"family": "Kim", "given": "Harold", "initials": "H"}, {"family": "Simons", "given": "Elinor", "initials": "E"}, {"family": "Upton", "given": "Julia", "initials": "J"}, {"family": "Protudjer", "given": "Jennifer L P", "initials": "JLP"}], "type": "journal article", "published": "2022-07-15", "journal": {"title": "Front Allergy", "issn": "2673-6101", "volume": "3", "pages": "915014", "issn-l": null}, "abstract": "The COVID-19 pandemic has affected the supply, cost, and demand for certain foods, but it is not clear how these changes have affected food-allergic households.\n\nTo describe the changes in food-related costs that have followed COVID-19, as reported by higher- and lower-income households with a food-allergic member.\n\nBetween May 1-June 30, 2020, Canadian households, with at least one food-allergic member, completed an online survey on food shopping and preparation habits before and during the COVID-19 pandemic. The sample was divided into binary groups, either higher or lower than the sample median income. Data were analyzed using descriptive statistics and multiple regression.\n\nThe sample was comprised of 102 participants (i.e., 51/ income group). The three most common food allergies amongst both groups were peanuts, tree nuts and milk. Since the start of the pandemic, both groups reported greater monthly direct grocery costs, although costs amongst the higher-income group were twice as high as the lower-income group ($212.86 vs. $98.89, respectively). Indirect food preparation costs were similarly elevated. Higher-income households with food procurement difficulties reported increased indirect shopping costs following the outbreak of COVID-19, whereas those without such difficulties reported decreased costs. Lower-income households with allergies to milk, wheat, or eggs (i.e., staple allergy) experienced a larger change in indirect food preparation costs following the outbreak of COVID-19 relative to those with other food allergies ($244.58 vs. -$20.28, respectively; p = 0.03).\n\nBoth higher and lower income households with food allergy reported greater direct food costs and indirect food preparation costs following the COVID-19. Households with staple allergy and those with difficulties finding their typical food items were particularly affected.", "doi": "10.3389/falgy.2022.915014", "pmid": "35910861", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9334569"}], "notes": [], "created": "2022-08-11T12:05:21.065Z", "modified": "2022-08-11T12:05:21.099Z"}, {"entity": "publication", "iuid": "c7807ad156c64452a058896d3a6ab36b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7807ad156c64452a058896d3a6ab36b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7807ad156c64452a058896d3a6ab36b"}}, "title": "Protective effects of statins on COVID-19 risk, severity and fatal outcome: a nationwide Swedish cohort study.", "authors": [{"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Franz\u00e9n", "given": "Stefan", "initials": "S"}, {"family": "N\u00e5tman", "given": "Jonatan", "initials": "J"}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Parmryd", "given": "Ingela", "initials": "I"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2022-07-14", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "12047", "issn-l": "2045-2322"}, "abstract": "The impact of statins on COVID-19 remains unclear. This study aims to investigate whether statin exposure assessed both in the population and in well-defined cohorts of COVID-19 patients may affect the risk and severity of COVID-19 using nationwide Swedish population-based register data. A population \u2265 40 years was selected by age/sex-stratified random sampling from the Swedish population on 1 Jan 2020. COVID-19 outcomes were identified from the SmiNet database, the National Patient Register and/or Cause-of-Death Register and linked with the National Prescribed Drug Register and sociodemographic registers. Statin exposure was defined as any statin prescriptions in the year before index date. In Cox regressions, confounding was addressed using propensity score ATT (Average Treatment effect in the Treated) weighting. Of 572,695 individuals in the overall cohort, 22.3% had prior statin treatment. After ATT weighting, protective effects were observed among statin user for hospitalization and COVID-19 death in the overall cohort and onset cohort. In the hospitalized cohort, statin use was only associated with lower risk for death (HR = 0.86, 95% CI 0.79-0.95), but not ICU admission. Statin-treated individuals appear to have lower COVID-19 mortality than nonusers, whether assessed in the general population, from COVID-19 onset or from hospitalization.", "doi": "10.1038/s41598-022-16357-2", "pmid": "35835835", "labels": {"Topics: Register-based research": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-16357-2"}, {"db": "pmc", "key": "PMC9282150"}], "notes": [], "created": "2022-08-12T09:01:17.228Z", "modified": "2022-08-12T09:02:19.709Z"}, {"entity": "publication", "iuid": "f6f8942eecdf4d63ad6c37b4691d8742", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6f8942eecdf4d63ad6c37b4691d8742.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6f8942eecdf4d63ad6c37b4691d8742"}}, "title": "Work-Life Enrichment and Interference Among Swedish Workers: Trends From 2016 Until the COVID-19 Pandemic.", "authors": [{"family": "Brulin", "given": "Emma", "initials": "E"}, {"family": "Leineweber", "given": "Constanze", "initials": "C"}, {"family": "Peristera", "given": "Paraskevi", "initials": "P"}], "type": "journal article", "published": "2022-07-13", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "13", "pages": "854119", "issn-l": "1664-1078"}, "abstract": "The COVID-19 pandemic has altered workers' possibilities to combine work and private life. Work and private life could either interfere with each other, that is, when conflicting demands arise, or enrich, that is, when the two roles are beneficial to one another. Analyzing data from the Swedish Longitudinal Occupational Survey of Health through individual growth models, we investigated time trends of interference and enrichment between work and private life from 2016 through March to September 2020, which is during the first wave of the pandemic. The sample included workers who had remained in the same workplace throughout the study period and worked at least 30% of full time, reaching 5,465 individuals. In addition, we examined trends in level of interference and enrichment across gender and industries. Results showed that Life-to-work interference increased over time in the Swedish working population, but neither did work-to-life interference nor enrichment. We observed only marginal differences across gender. Also, in the industries of fine manufacturing and real-estate activities, a decrease in interference, work-to-life interference, and life-to-work interference, respectively, was observed. In the human health and social care industry, an increase in interference and life-to-work interference was seen. Our conclusion is that overall changes to the possibilities to balance work and private life have occurred for workers in Sweden during the first period of the pandemic. Further studies are needed to study development time trends throughout the pandemic and across different occupations.", "doi": "10.3389/fpsyg.2022.854119", "pmid": "35910960", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9328076"}], "notes": [], "created": "2022-08-11T12:05:05.016Z", "modified": "2022-08-11T12:05:05.022Z"}, {"entity": "publication", "iuid": "b396337b473149e2918bc8cd12aeffaf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b396337b473149e2918bc8cd12aeffaf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b396337b473149e2918bc8cd12aeffaf"}}, "title": "Effectiveness of a fourth dose of mRNA COVID-19 vaccine against all-cause mortality in long-term care facility residents and in the oldest old: A nationwide, retrospective cohort study in Sweden.", "authors": [{"family": "Nordstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Ballin", "given": "Marcel", "initials": "M"}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-07-13", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "pages": "100466", "issn-l": null}, "abstract": "The effect of a fourth dose of COVID-19 vaccine on the risk of death in the oldest and frailest individuals is unknown.\n\nTwo matched cohorts were formed using Swedish nationwide registers. In the first, residents of long-term care facilities (LTCFs) given a fourth dose of an mRNA vaccine from 1 January 2022 onwards were matched 1:1 on birth year and county of residence to residents given at least a third dose (N = 24,524). In the second, all individuals aged \u226580 years given a fourth dose were matched 1:1 to individuals given at least a third dose (N = 394,104). Cox regression models were used to estimate hazard ratios for all-cause mortality in fourth-dose recipients as compared with in third-dose recipients, with relative vaccine effectiveness (VE) estimated as 1 minus the hazard ratio.\n\nFrom 7 days after baseline and onwards, there were 1119 deaths in the LTCF cohort during a median follow-up of 77 days and a maximum follow-up of 126 days. During days 7 to 60, the VE of the fourth dose was 39% (95% CI, 29-48), which declined to 27% (95% CI, -2-48) during days 61 to 126. In the cohort of all individuals aged \u226580 years, there were 5753 deaths during a median follow-up of 73 days and a maximum follow-up of 143 days. During days 7 to 60, the VE of the fourth dose was 71% (95% CI, 69-72), which declined to 54% (95% CI, 48-60) during days 61 to 143. The VE of the fourth dose seemed stronger when it was compared to third-dose recipients where at least four months had passed since vaccination (P < 0\u00b7001 for interaction).\n\nAs compared with a third dose, a fourth dose of an mRNA COVID-19 vaccine, administered during the Omicron era, was associated with reduced risk of death from all causes in residents of LTCFs and in the oldest old during the first two months, after which the protection became slightly lower. These findings suggest that a fourth dose may prevent premature mortality in the oldest and frailest even after the emergence of the Omicron variant, although the timing of vaccination seems to be important with respect to the slight waning observed after two months.\n\nThere was no funding source for this study.", "doi": "10.1016/j.lanepe.2022.100466", "pmid": "35855494", "labels": {"Topics: Register-based research": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(22)00162-4"}, {"db": "pmc", "key": "PMC9277096"}], "notes": [], "created": "2022-08-12T08:48:27.521Z", "modified": "2022-08-12T08:48:27.527Z"}, {"entity": "publication", "iuid": "731c3b854fdd4693bbf5054df50f6f20", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/731c3b854fdd4693bbf5054df50f6f20.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/731c3b854fdd4693bbf5054df50f6f20"}}, "title": "Community-based response to the COVID-19 pandemic: case study of a home isolation centre using flexible surge capacity.", "authors": [{"family": "Phattharapornjaroen", "given": "P", "initials": "P"}, {"family": "Carlstr\u00f6m", "given": "E", "initials": "E"}, {"family": "Sivarak", "given": "O", "initials": "O"}, {"family": "Tansuwannarat", "given": "P", "initials": "P"}, {"family": "Chalermdamrichai", "given": "P", "initials": "P"}, {"family": "Sittichanbuncha", "given": "Y", "initials": "Y"}, {"family": "Kongtoranin", "given": "L", "initials": "L"}, {"family": "Phattranonuthai", "given": "R", "initials": "R"}, {"family": "Marlow", "given": "P", "initials": "P"}, {"family": "Winyuchonjaroen", "given": "W", "initials": "W"}, {"family": "Pongpasupa", "given": "N", "initials": "N"}, {"family": "Khorram-Manesh", "given": "A", "initials": "A"}], "type": "journal article", "published": "2022-07-13", "journal": {"title": "Public Health", "issn": "1476-5616", "volume": "211", "pages": "29-36", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) has consumed many available resources within contingency plans, necessitating new capacity surges and novel approaches. This study aimed to explore the possibility of implementing the concept of flexible surge capacity to reduce the burden on hospitals by focussing on community resources to develop home isolation centres in Bangkok, Thailand.\n\nA qualitative study consisted of observational and semi-structured interview data.\n\nThe development and activities of home isolation centres were observed, and interviews were conducted with leaders and operational workforces. Data were deductively analysed and categorised based on the practical elements necessary in disaster and emergency management.\n\nData were categorised into the seven collaborative elements of the major incident medical management and support model. The command-and-control category demonstrated four subcategories: (1) coordination and collaboration; (2) staff engagement; (3) responsibility clarification; and (4) sustainability. Safety presented two subcategories: (1) patients' information privacy and treatment; and (2) personnel safety and privacy. Communication showed internal and external communications subcategories. Assessment, triage, treatment and transport followed the processes of the COVID-19 treatment protocols according to the World Health Organisation (WHO) guidelines and hospital operations. Several supply- and patient-related challenges were identified and managed during centre development.\n\nThe use of community resources, based on the flexible surge capacity concept, is feasible under restricted circumstances and reduced the burden on hospitals during the COVID-19 pandemic. Continuous education among multidisciplinary volunteer teams facilitated their full participation and engagement. The concept of flexible surge capacity may promote an alternative community-based care opportunity, irrespective of emergencies' aetiology.", "doi": "10.1016/j.puhe.2022.06.025", "pmid": "35994836", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0033-3506(22)00182-2"}, {"db": "pmc", "key": "PMC9276643"}], "notes": [], "created": "2022-09-12T19:00:44.873Z", "modified": "2022-09-12T19:00:56.112Z"}, {"entity": "publication", "iuid": "9e30c2527eb24c79b180aa68c68b2d26", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9e30c2527eb24c79b180aa68c68b2d26.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9e30c2527eb24c79b180aa68c68b2d26"}}, "title": "mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells.", "authors": [{"family": "Bevers", "given": "Sanne", "initials": "S"}, {"family": "Kooijmans", "given": "Sander A A", "initials": "SAA"}, {"family": "Van de Velde", "given": "Elien", "initials": "E"}, {"family": "Evers", "given": "Martijn J W", "initials": "MJW"}, {"family": "Seghers", "given": "Sofie", "initials": "S"}, {"family": "Gitz-Francois", "given": "Jerney J J M", "initials": "JJJM"}, {"family": "van Kronenburg", "given": "Nicky C H", "initials": "NCH"}, {"family": "Fens", "given": "Marcel H A M", "initials": "MHAM"}, {"family": "Mastrobattista", "given": "Enrico", "initials": "E"}, {"family": "Hassler", "given": "Lucie", "initials": "L"}, {"family": "Sork", "given": "Helena", "initials": "H"}, {"family": "Lehto", "given": "Taavi", "initials": "T"}, {"family": "Ahmed", "given": "Kariem E", "initials": "KE"}, {"family": "El Andaloussi", "given": "Samir", "initials": "S"}, {"family": "Fiedler", "given": "Katja", "initials": "K"}, {"family": "Breckpot", "given": "Karine", "initials": "K"}, {"family": "Maes", "given": "Michael", "initials": "M"}, {"family": "Van Hoorick", "given": "Diane", "initials": "D"}, {"family": "Bastogne", "given": "Thierry", "initials": "T"}, {"family": "Schiffelers", "given": "Raymond M", "initials": "RM"}, {"family": "De Koker", "given": "Stefaan", "initials": "S"}], "type": "journal article", "published": "2022-07-12", "journal": {"title": "Mol Ther", "issn": "1525-0024", "issn-l": null}, "abstract": "mRNA vaccines have recently proved to be highly effective against SARS-CoV-2. Key to their success is the lipid-based nanoparticle (LNP), which enables efficient mRNA expression and endows the vaccine with adjuvant properties that drive potent antibody responses. Effective cancer vaccines require long-lived, qualitative CD8 T cell responses instead of antibody responses. Systemic vaccination appears to be the most effective route, but necessitates adaptation of LNP composition to deliver mRNA to antigen-presenting cells. Using a design-of-experiments methodology, we tailored mRNA-LNP compositions to achieve high-magnitude tumor-specific CD8 T cell responses within a single round of optimization. Optimized LNP compositions resulted in enhanced mRNA uptake by multiple splenic immune cell populations. Type I interferon and phagocytes were found to be essential for the T cell response. Surprisingly, we also discovered a yet unidentified role of B cells in stimulating the vaccine-elicited CD8 T cell response. Optimized LNPs displayed a similar, spleen-centered biodistribution profile in non-human primates and did not trigger histopathological changes in liver and spleen, warranting their further assessment in clinical studies. Taken together, our study clarifies the relationship between nanoparticle composition and their T cell stimulatory capacity and provides novel insights into the underlying mechanisms of effective mRNA-LNP-based antitumor immunotherapy.", "doi": "10.1016/j.ymthe.2022.07.007", "pmid": "35821637", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S1525-0016(22)00428-2"}, {"db": "pmc", "key": "PMC9273295"}], "notes": [], "created": "2022-08-17T10:36:40.221Z", "modified": "2022-08-17T10:36:52.133Z"}, {"entity": "publication", "iuid": "c1c8534aa33042ff8fe7fa5a16399331", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1c8534aa33042ff8fe7fa5a16399331.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1c8534aa33042ff8fe7fa5a16399331"}}, "title": "Working conditions for hospital-based maternity and neonatal health care workers during extraordinary situations - A pre-/post COVID-19 pandemic analysis and lessons learned.", "authors": [{"family": "Akerstrom", "given": "Magnus", "initials": "M"}, {"family": "Carlsson", "given": "Ylva", "initials": "Y"}, {"family": "Sengpiel", "given": "Verena", "initials": "V"}, {"family": "Veje", "given": "Malin", "initials": "M"}, {"family": "Elfvin", "given": "Anders", "initials": "A"}, {"family": "Jonsdottir", "given": "Ingibj\u00f6rg H", "initials": "IH"}, {"family": "Degl'Innocenti", "given": "Alessio", "initials": "A"}, {"family": "Ahlstrom", "given": "Linda", "initials": "L"}, {"family": "Wijk", "given": "Helle", "initials": "H"}, {"family": "Linden", "given": "Karolina", "initials": "K"}], "type": "journal article", "published": "2022-07-12", "journal": {"title": "Sex Reprod Healthc", "issn": "1877-5764", "volume": "33", "pages": "100755", "issn-l": null}, "abstract": "The aim of this study was to investigate how the changed work routines during the COVID-19 pandemic has been affecting the working environment for hospital-based maternity and neonatal health care workers, and to identify preventive measures to be used in future situations when health care organizations are under pressure.\n\nAll maternity and neonatal health care workers in a Swedish university hospital were surveyed during October 2019 and September 2020. The data was analyzed by document analysis of implemented changes in working routines, a quantitative analysis of the overall effects on the working conditions, and a qualitative analysis of open-ended responses.\n\nA total of 660 maternity and neonatal health care workers completed the pre-COVID-19 survey (74% response rate) and 382 the COVID-19 survey (35% response rate). Lack of personal protective equipment, worry about becoming infected, uncertainty whether implemented changes were enough, and challenges in communicating updated routines had negative effects on maternity and neonatal health care workers' working conditions. Team spirit and feeling valued by peers had a positive effect.\n\nResults suggest that negative effects on maternity and neonatal health care workers' health can partly be prevented in future critical situations by creating a work climate that acknowledges the employees' worry about being infected, securing adequate pre-conditions for managers, creating a strong psychosocial safety climate and systematically improving the working conditions for the maternity and neonatal health care workers, as well as maintaining the positive perceived effects of increased team spirit and feeling valued by peers.", "doi": "10.1016/j.srhc.2022.100755", "pmid": "35853385", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1877-5756(22)00061-1"}, {"db": "pmc", "key": "PMC9273518"}], "notes": [], "created": "2022-08-12T08:50:16.161Z", "modified": "2022-08-12T08:50:16.166Z"}, {"entity": "publication", "iuid": "77d56ca741194f1b8a8d8f00738a6877", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/77d56ca741194f1b8a8d8f00738a6877.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/77d56ca741194f1b8a8d8f00738a6877"}}, "title": "School Nurses' Perceptions About Student's Wellbeing During the Covid-19 Pandemic in Sweden.", "authors": [{"family": "Martinsson", "given": "Eva", "initials": "E"}, {"family": "Garmy", "given": "Pernilla", "initials": "P", "orcid": "0000-0003-1643-0171", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc4733a9e87a42fea6e7a7323feb61b3.json"}}, {"family": "Einberg", "given": "Eva-Lena", "initials": "EL", "orcid": "0000-0002-5586-3810", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d67e636861d492fb682ec1601422cd0.json"}}], "type": "journal article", "published": "2022-07-12", "journal": {"title": "J Sch Nurs", "issn": "1546-8364", "pages": "10598405221112443", "issn-l": null}, "abstract": "The coronavirus 2019 (Covid-19) pandemic has affected both the private and public lives of people worldwide. Countries have chosen different strategies to reduce the spread of infection, including school closures and distance learning. This study aimed to describe school nurses' perceptions about the wellbeing of students during the Covid-19 pandemic in Sweden. Interviews in five focus groups and one individual were conducted with 17 school nurses in Sweden. The interviews were analyzed using a qualitative content analysis. According to the school nurses' perceptions, students were concerned about spreading infection, becoming infected themselves, their academic performances, and longing for socialization. The change in the school situation involved a slower pace and less anxiety for some students, more or less physical activity, and an increase in screen time.", "doi": "10.1177/10598405221112443", "pmid": "35822231", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9280116"}], "notes": [], "created": "2022-08-17T10:36:15.715Z", "modified": "2022-08-17T10:36:15.752Z"}, {"entity": "publication", "iuid": "ccdb507805c448e09e20070e7245ba29", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ccdb507805c448e09e20070e7245ba29.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ccdb507805c448e09e20070e7245ba29"}}, "title": "Prevalence of fatigue at one-year follow-up from the Gothenburg recovery and rehabilitation after COVID-19 and intensive care unit study.", "authors": [{"family": "Hussain", "given": "Netha", "initials": "N"}, {"family": "Samuelsson", "given": "Carina M", "initials": "CM"}, {"family": "Drummond", "given": "Avril", "initials": "A"}, {"family": "Persson", "given": "Carina U", "initials": "CU"}], "type": "journal article", "published": "2022-07-12", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "11501", "issn-l": "2045-2322"}, "abstract": "Fatigue was a commonly reported sequala after COVID-19. However, there is little literature about the prevalence and predictors of fatigue one year after Intensive Care Unit (ICU) admission following COVID-19. Therefore, the aim of this study was to determine the prevalence of fatigue and to identify the predictors prior to, and during the care period in ICU that were associated with fatigue at one year after ICU admission following COVID-19. The dependent variable, fatigue, was assessed using the Swedish version of Fatigue Assessment Scale (S-FAS), in a cohort of 105 individuals cared for at the ICU at the Sahlgrenska University hospital, Sweden during the first wave of the pandemic. The independent variables were related to demographic factors, comorbidities and complications during ICU admission following COVID-19. Fatigue was reported by 64.4% (n = 67) of the individuals. Age (odds ratio: 0.95, confidence interval: 0.92-0.99) and length of stay in the ICU (odds ratio: 1.04, confidence interval: 1.00-1.07) were statistically significant predictors of fatigue one year after ICU admission following COVID-19. The findings from this study will be important for healthcare practitioners, policy makers and the general public in planning the rehabilitation of individuals who underwent ICU care for COVID-19.", "doi": "10.1038/s41598-022-14787-6", "pmid": "35821226", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-14787-6"}, {"db": "pmc", "key": "PMC9276681"}], "notes": [], "created": "2022-08-17T10:37:13.798Z", "modified": "2022-08-17T10:37:13.811Z"}, {"entity": "publication", "iuid": "0fd3e4f3d2f8406f88be2ebd9ec8eef9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0fd3e4f3d2f8406f88be2ebd9ec8eef9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0fd3e4f3d2f8406f88be2ebd9ec8eef9"}}, "title": "Directly immersible silicon photonic probes: Application to rapid SARS-CoV-2 serological testing.", "authors": [{"family": "Angelopoulou", "given": "Michailia", "initials": "M"}, {"family": "Makarona", "given": "Eleni", "initials": "E"}, {"family": "Salapatas", "given": "Alexandros", "initials": "A"}, {"family": "Misiakos", "given": "Konstantinos", "initials": "K"}, {"family": "Synolaki", "given": "Evgenia", "initials": "E"}, {"family": "Ioannidis", "given": "Anastasios", "initials": "A"}, {"family": "Chatzipanagiotou", "given": "Stylianos", "initials": "S"}, {"family": "Ritvos", "given": "Mikael A", "initials": "MA"}, {"family": "Pasternack", "given": "Arja", "initials": "A"}, {"family": "Ritvos", "given": "Olli", "initials": "O"}, {"family": "Petrou", "given": "Panagiota S", "initials": "PS"}, {"family": "Kakabakos", "given": "Sotirios E", "initials": "SE"}], "type": "journal article", "published": "2022-07-12", "journal": {"title": "Biosens Bioelectron", "issn": "1873-4235", "volume": "215", "pages": "114570", "issn-l": null}, "abstract": "Silicon photonic probes based on broad-band Mach-Zehnder interferometry are explored for the first time as directly immersible immunosensors alleviating the need for microfluidics and pumps. Each probe includes two U-shaped waveguides allowing light in- and out-coupling from the same chip side through a bifurcated fiber and a mechanical coupler. At the opposite chip side, two Mach-Zehnder interferometers (MZI) are located enabling real-time monitoring of binding reactions by immersion of this chip side into a sample. The sensing arm windows of the two MZIs have different length resulting in two distinct peaks in the Fourier domain, the phase shift of which can be monitored independently through Fast Fourier Transform of the output spectrum. The photonic probes analytical potential was demonstrated through detection of antibodies against SARS-CoV-2 in human serum samples. For this, one MZI was functionalized with the Receptor Binding Domain (RBD) of SARS-CoV-2 Spike 1 protein, and the other with bovine serum albumin to serve as reference. The biofunctionalized probes were immersed for 10 min in human serum sample and then for 5 min in goat anti-human IgG Fc specific antibody solution. Using a humanized rat antibody against SARS-CoV-2 RBD, a detection limit of 20 ng/mL was determined. Analysis of human serum samples indicated that the proposed sensor discriminated completely non-infected/non-vaccinated from vaccinated individuals, and the antibodies levels determined correlated well with those determined in the same samples by ELISA. These results demonstrated the potential of the proposed sensor to serve as an efficient tool for expeditious point-of-care testing.", "doi": "10.1016/j.bios.2022.114570", "pmid": "35850040", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0956-5663(22)00610-8"}, {"db": "pmc", "key": "PMC9273522"}], "notes": [], "created": "2022-08-12T08:51:43.044Z", "modified": "2022-08-12T08:51:43.074Z"}, {"entity": "publication", "iuid": "dec4fedc676d4600898cf479f3c3f403", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dec4fedc676d4600898cf479f3c3f403.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dec4fedc676d4600898cf479f3c3f403"}}, "title": "Clinical prediction models for mortality in patients with covid-19: external validation and individual participant data meta-analysis.", "authors": [{"family": "de Jong", "given": "Valentijn M T", "initials": "VMT", "orcid": "0000-0001-9921-3468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5147390937d4bdbb706fd24820bdabc.json"}}, {"family": "Rousset", "given": "Rebecca Z", "initials": "RZ", "orcid": "0000-0001-9355-7286", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/657ff3d472c94b598267473a115a9a24.json"}}, {"family": "Antonio-Villa", "given": "Neftal\u00ed Eduardo", "initials": "NE", "orcid": "0000-0002-6879-1078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2f6ed0f02a24c9db9ec0a0f2a138302.json"}}, {"family": "Buenen", "given": "Arnoldus G", "initials": "AG", "orcid": "0000-0002-0948-1379", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c3427d44e1d840729a381a2a95fd13c2.json"}}, {"family": "Van Calster", "given": "Ben", "initials": "B", "orcid": "0000-0003-1613-7450", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47c7125c051c47b58e7a6462f2ddc79b.json"}}, {"family": "Bello-Chavolla", "given": "Omar Yaxmehen", "initials": "OY", "orcid": "0000-0003-3093-937X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/17af31a1a5914f5bbfa87a312ffdc995.json"}}, {"family": "Brunskill", "given": "Nigel J", "initials": "NJ"}, {"family": "Curcin", "given": "Vasa", "initials": "V", "orcid": "0000-0002-8308-2886", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91c85856301d422b8071753e1d36fd31.json"}}, {"family": "Damen", "given": "Johanna A A", "initials": "JAA", "orcid": "0000-0001-7401-4593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b6107f804af47a3a2b27ceeb6ade6ca.json"}}, {"family": "Ferm\u00edn-Mart\u00ednez", "given": "Carlos A", "initials": "CA", "orcid": "0000-0001-5627-8851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10fdb216049244a6a7d87788674e9a4e.json"}}, {"family": "Fern\u00e1ndez-Chirino", "given": "Luisa", "initials": "L", "orcid": "0000-0002-8326-1219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c06b680084d548d88e4b29e70ed06be4.json"}}, {"family": "Ferrari", "given": "Davide", "initials": "D", "orcid": "0000-0003-2365-4157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/419cc33149304e7ab894b00491377ffd.json"}}, {"family": "Free", "given": "Robert C", "initials": "RC"}, {"family": "Gupta", "given": "Rishi K", "initials": "RK", "orcid": "0000-0002-6257-1285", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/199d63fa58c84f44ba02d388cf89bdb7.json"}}, {"family": "Haldar", "given": "Pranabashis", "initials": "P"}, {"family": "Hedberg", "given": "Pontus", "initials": "P", "orcid": "0000-0003-3153-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd6af5accfc84ff9a81983a5ab6683aa.json"}}, {"family": "Korang", "given": "Steven Kwasi", "initials": "SK", "orcid": "0000-0002-6521-0928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a3fa688bba644138b31d213fefeb31e.json"}}, {"family": "Kurstjens", "given": "Steef", "initials": "S"}, {"family": "Kusters", "given": "Ron", "initials": "R"}, {"family": "Major", "given": "Rupert W", "initials": "RW", "orcid": "0000-0003-4920-623X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/853c99a3b7b149c8a0b6f28d29013785.json"}}, {"family": "Maxwell", "given": "Lauren", "initials": "L"}, {"family": "Nair", "given": "Rajeshwari", "initials": "R"}, {"family": "Naucler", "given": "Pontus", "initials": "P", "orcid": "0000-0002-8185-2648", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78b415aee4864810b8ce8f1962fa288f.json"}}, {"family": "Nguyen", "given": "Tri-Long", "initials": "TL", "orcid": "0000-0002-6376-7212", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4869454669049bab81bb55809f3a446.json"}}, {"family": "Noursadeghi", "given": "Mahdad", "initials": "M"}, {"family": "Rosa", "given": "Rossana", "initials": "R", "orcid": "0000-0002-3755-7780", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13954374ed884b65b833316c1ce8991d.json"}}, {"family": "Soares", "given": "Felipe", "initials": "F", "orcid": "0000-0002-2837-1853", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7f180e740e4496b867c75535a5ddf2c.json"}}, {"family": "Takada", "given": "Toshihiko", "initials": "T", "orcid": "0000-0002-8032-6224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/285f5b69f2c741c3a6e7b268123c5a97.json"}}, {"family": "van Royen", "given": "Florien S", "initials": "FS", "orcid": "0000-0002-6785-214X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d92466b48a0e43f5aa2e326eff1457d6.json"}}, {"family": "van Smeden", "given": "Maarten", "initials": "M", "orcid": "0000-0002-5529-1541", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8dd2487a416242099bd2dffdc5d05be9.json"}}, {"family": "Wynants", "given": "Laure", "initials": "L", "orcid": "0000-0002-3037-122X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb8e9ef168d444e9b821f22e9a4e06ff.json"}}, {"family": "Modr\u00e1k", "given": "Martin", "initials": "M", "orcid": "0000-0002-8886-7797", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e1aceac9a864506b36dbfddab9608c5.json"}}, {"family": "CovidRetro collaboration", "given": "", "initials": ""}, {"family": "Asselbergs", "given": "Folkert W", "initials": "FW", "orcid": "0000-0002-1692-8669", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/578ce5a865454ff3be1545f940cabbdc.json"}}, {"family": "Linschoten", "given": "Marijke", "initials": "M", "orcid": "0000-0002-4541-080X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7714859c3fc420088a20cf23eda12cb.json"}}, {"family": "CAPACITY-COVID consortium", "given": "", "initials": ""}, {"family": "Moons", "given": "Karel G M", "initials": "KGM"}, {"family": "Debray", "given": "Thomas P A", "initials": "TPA", "orcid": "0000-0002-1790-2719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/343d2f07d494422f91507fd6bca0dcad.json"}}], "type": "journal article", "published": "2022-07-12", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "378", "pages": "e069881", "issn-l": null}, "abstract": "To externally validate various prognostic models and scoring rules for predicting short term mortality in patients admitted to hospital for covid-19.\n\nTwo stage individual participant data meta-analysis.\n\nSecondary and tertiary care.\n\n46 914 patients across 18 countries, admitted to a hospital with polymerase chain reaction confirmed covid-19 from November 2019 to April 2021.\n\nMultiple (clustered) cohorts in Brazil, Belgium, China, Czech Republic, Egypt, France, Iran, Israel, Italy, Mexico, Netherlands, Portugal, Russia, Saudi Arabia, Spain, Sweden, United Kingdom, and United States previously identified by a living systematic review of covid-19 prediction models published in The BMJ, and through PROSPERO, reference checking, and expert knowledge.\n\nPrognostic models identified by the living systematic review and through contacting experts. A priori models were excluded that had a high risk of bias in the participant domain of PROBAST (prediction model study risk of bias assessment tool) or for which the applicability was deemed poor.\n\nEight prognostic models with diverse predictors were identified and validated. A two stage individual participant data meta-analysis was performed of the estimated model concordance (C) statistic, calibration slope, calibration-in-the-large, and observed to expected ratio (O:E) across the included clusters.\n\n30 day mortality or in-hospital mortality.\n\nDatasets included 27 clusters from 18 different countries and contained data on 46 914patients. The pooled estimates ranged from 0.67 to 0.80 (C statistic), 0.22 to 1.22 (calibration slope), and 0.18 to 2.59 (O:E ratio) and were prone to substantial between study heterogeneity. The 4C Mortality Score by Knight et al (pooled C statistic 0.80, 95% confidence interval 0.75 to 0.84, 95% prediction interval 0.72 to 0.86) and clinical model by Wang et al (0.77, 0.73 to 0.80, 0.63 to 0.87) had the highest discriminative ability. On average, 29% fewer deaths were observed than predicted by the 4C Mortality Score (pooled O:E 0.71, 95% confidence interval 0.45 to 1.11, 95% prediction interval 0.21 to 2.39), 35% fewer than predicted by the Wang clinical model (0.65, 0.52 to 0.82, 0.23 to 1.89), and 4% fewer than predicted by Xie et al's model (0.96, 0.59 to 1.55, 0.21 to 4.28).\n\nThe prognostic value of the included models varied greatly between the data sources. Although the Knight 4C Mortality Score and Wang clinical model appeared most promising, recalibration (intercept and slope updates) is needed before implementation in routine care.", "doi": "10.1136/bmj-2021-069881", "pmid": "35820692", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9273913"}], "notes": [], "created": "2022-08-17T10:37:35.184Z", "modified": "2022-08-17T10:37:36.106Z"}, {"entity": "publication", "iuid": "81ad262b687b4469a0d28c40a200cfb4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/81ad262b687b4469a0d28c40a200cfb4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/81ad262b687b4469a0d28c40a200cfb4"}}, "title": "Impact of COVID-19 pandemic on families living with autism: An online survey.", "authors": [{"family": "Isensee", "given": "Corinna", "initials": "C"}, {"family": "Schmid", "given": "Benjamin", "initials": "B"}, {"family": "Marschik", "given": "Peter B", "initials": "PB"}, {"family": "Zhang", "given": "Dajie", "initials": "D"}, {"family": "Poustka", "given": "Luise", "initials": "L"}], "type": "journal article", "published": "2022-07-11", "journal": {"title": "Res Dev Disabil", "issn": "1873-3379", "volume": "129", "pages": "104307", "issn-l": null}, "abstract": "The current SARS-CoV-2 global pandemic presents a great challenge for governments, health care professionals and the general population. Individuals with autism spectrum disorder (ASD) might be especially vulnerable to restrictions imposed by the crisis.\n\nThe objective of the study was to examine the impact of the SARSCoV- 2 pandemic on children with ASD and their families.\n\nWe conducted an online survey two months after the beginning of lock-down (18th of May to 5th of July 2020) in Germany and Austria. We investigated behavioral and emotional changes of children related to the lock-down alongside parental stress and intrafamilial burden OUTCOME AND RESULTS: Of the 216 participating families with an autistic child (mean age: 12.23 years), nearly 50% reported aggravation of autistic symptoms and heightened parental stress. Families reported discontinuation of therapy, more intrafamilial conflicts and increase of psychopharmacological medication of the child.\n\nOur report on short-term detrimental effects of the pandemic calls for thorough investigation of long-term sequalae for children and families.", "doi": "10.1016/j.ridd.2022.104307", "pmid": "35908370", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0891-4222(22)00137-8"}, {"db": "pmc", "key": "PMC9271458"}], "notes": [], "created": "2022-08-12T08:31:03.122Z", "modified": "2022-08-12T08:31:03.149Z"}, {"entity": "publication", "iuid": "f6c3188e1df54926b231706fa4c42a81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6c3188e1df54926b231706fa4c42a81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6c3188e1df54926b231706fa4c42a81"}}, "title": "IMpact of COVID-19 in Patients With Severe Alpha-1 Antitrypsin Deficiency: The IMCA1 Study of the EARCO Clinical Research Collaboration.", "authors": [{"family": "Parr", "given": "David G", "initials": "DG"}, {"family": "Chorostowska-Wynimko", "given": "Joanna", "initials": "J"}, {"family": "Corsico", "given": "Angelo", "initials": "A"}, {"family": "Esquinas", "given": "Cristina", "initials": "C"}, {"family": "McElvaney", "given": "Gerard N", "initials": "GN"}, {"family": "Sark", "given": "Annelot D", "initials": "AD"}, {"family": "Sucena", "given": "Maria", "initials": "M"}, {"family": "Tanash", "given": "Hanan", "initials": "H"}, {"family": "Turner", "given": "Alice M", "initials": "AM"}, {"family": "Miravitlles", "given": "Marc", "initials": "M"}], "type": "case reports", "published": "2022-07-11", "journal": {"title": "Arch Bronconeumol", "issn": "1579-2129", "issn-l": null}, "abstract": null, "doi": "10.1016/j.arbres.2022.07.002", "pmid": "35879122", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0300-2896(22)00488-4"}, {"db": "pmc", "key": "PMC9272568"}], "notes": [], "created": "2022-08-12T08:38:44.333Z", "modified": "2022-08-12T08:38:44.362Z"}, {"entity": "publication", "iuid": "7342214e725c4fedba1cba39059bd007", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7342214e725c4fedba1cba39059bd007.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7342214e725c4fedba1cba39059bd007"}}, "title": "Building Process-Oriented Data Science Solutions for Real-World Healthcare.", "authors": [{"family": "Fernandez-Llatas", "given": "Carlos", "initials": "C", "orcid": "0000-0002-2819-5597", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/571fddd1da9f4a4cab2c5b3a35e1214e.json"}}, {"family": "Martin", "given": "Niels", "initials": "N", "orcid": "0000-0003-3279-3853", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7adc49ffd4c04f5990561757d9b05060.json"}}, {"family": "Johnson", "given": "Owen", "initials": "O"}, {"family": "Sepulveda", "given": "Marcos", "initials": "M", "orcid": "0000-0002-9467-7666", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46fce16f5df54618aabfb09089b1057f.json"}}, {"family": "Helm", "given": "Emmanuel", "initials": "E", "orcid": "0000-0002-1323-3511", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/909fe49fc92243eaab55745571d20610.json"}}, {"family": "Munoz-Gama", "given": "Jorge", "initials": "J", "orcid": "0000-0002-6908-3911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/217b35c6e73f4c5b91e953948735f8c8.json"}}], "type": "editorial", "published": "2022-07-10", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "14", "issn-l": null}, "abstract": "The COVID-19 pandemic has highlighted some of the opportunities, problems and barriers facing the application of Artificial Intelligence to the medical domain. It is becoming increasingly important to determine how Artificial Intelligence will help healthcare providers understand and improve the daily practice of medicine. As a part of the Artificial Intelligence research field, the Process-Oriented Data Science community has been active in the analysis of this situation and in identifying current challenges and available solutions. We have identified a need to integrate the best efforts made by the community to ensure that promised improvements to care processes can be achieved in real healthcare. In this paper, we argue that it is necessary to provide appropriate tools to support medical experts and that frequent, interactive communication between medical experts and data miners is needed to co-create solutions. Process-Oriented Data Science, and specifically concrete techniques such as Process Mining, can offer an easy to manage set of tools for developing understandable and explainable Artificial Intelligence solutions. Process Mining offers tools, methods and a data driven approach that can involve medical experts in the process of co-discovering real-world evidence in an interactive way. It is time for Process-Oriented Data scientists to collaborate more closely with healthcare professionals to provide and build useful, understandable solutions that answer practical questions in daily practice. With a shared vision, we should be better prepared to meet the complex challenges that will shape the future of healthcare.", "doi": "10.3390/ijerph19148427", "pmid": "35886279", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "ijerph19148427"}, {"db": "pmc", "key": "PMC9318799"}], "notes": [], "created": "2022-08-12T08:35:57.278Z", "modified": "2022-08-12T08:35:57.470Z"}, {"entity": "publication", "iuid": "94bf1b1dc8d44a16aecfb754f15419aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/94bf1b1dc8d44a16aecfb754f15419aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/94bf1b1dc8d44a16aecfb754f15419aa"}}, "title": "Epilepsy diagnosis after Covid-19: A population-wide study.", "authors": [{"family": "Westman", "given": "Gabriel", "initials": "G"}, {"family": "Zelano", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2022-07-09", "journal": {"title": "Seizure", "issn": "1532-2688", "volume": "101", "pages": "11-14", "issn-l": null}, "abstract": "We aimed to investigate whether SARS-CoV-2 infection was associated with an increased risk of incident epilepsy.\n\nNational register-based matched study. Verified cases of SARS-CoV-2 infection were acquired from the system for communicable disease surveillance in Sweden (SmiNet) and linked to data from the National Patient Register (NPR) and Cause of Death register in Sweden. Cases and non-infected controls were compared using a Cox proportional hazards model.\n\nA total of 1,221,801 SARS-CoV-2 infected patients and 1,223,312 controls were included. Infection was not associated with an increased risk of epilepsy on a whole population level (HR 1.01, 95% CI 0.92-1.12). Statistically significant effects were observed in patients between 61 and 80 years (HR 1.66, 95% CI 1.37-2.02), also when adjusting for stroke, traumatic brain injury, tumours (same age group HR 1.50, 95% CI 1.24-1.82) and mechanical ventilation (HR 1.28, 95% CI 1.05-1.57). In patients 81-100 years, a similar significant difference was observed (HR 1.77, 95% CI 1.30-2.42), which remained after adjustment for stroke, traumatic brain injury and tumours (HR 1.51, 95% CI 1.10-2.05) but not when mechanical ventilation was included as a covariate (HR 1.34, 95% CI 0.97-1.84).\n\nOn a whole population level, SARS-CoV-2 infections is not associated with an increased risk of epilepsy. In patients above 60 years, a moderately increased risk of epilepsy was observed. However, considering potential non-controllable bias and that Covid-19 patients in intensive care present with a lower risk than the general ICU population, the virus-induced epileptogenic effect is likely very small.", "doi": "10.1016/j.seizure.2022.07.005", "pmid": "35842976", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1059-1311(22)00158-3"}, {"db": "pmc", "key": "PMC9270960"}], "notes": [], "created": "2022-08-12T08:54:07.719Z", "modified": "2022-08-12T08:54:48.844Z"}, {"entity": "publication", "iuid": "f6c12008f39a4cfaa851666b5c3309d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6c12008f39a4cfaa851666b5c3309d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6c12008f39a4cfaa851666b5c3309d4"}}, "title": "Differences between Omicron SARS-CoV-2 RBD and other variants in their ability to interact with cell receptors and monoclonal antibodies.", "authors": [{"family": "Giron", "given": "Carolina Corr\u00eaa", "initials": "CC"}, {"family": "Laaksonen", "given": "Aatto", "initials": "A"}, {"family": "Barroso da Silva", "given": "Fernando Lu\u00eds", "initials": "FL"}], "type": "journal article", "published": "2022-07-09", "journal": {"title": "J Biomol Struct Dyn", "issn": "1538-0254", "pages": "1-21", "issn-l": null}, "abstract": "SARS-CoV-2 remains a health threat with the continuous emergence of new variants. This work aims to expand the knowledge about the SARS-CoV-2 receptor-binding domain (RBD) interactions with cell receptors and monoclonal antibodies (mAbs). By using constant-pH Monte Carlo simulations, the free energy of interactions between the RBD from different variants and several partners (Angiotensin-Converting Enzyme-2 (ACE2) polymorphisms and various mAbs) were predicted. Computed RBD-ACE2-binding affinities were higher for two ACE2 polymorphisms (rs142984500 and rs4646116) typically found in Europeans which indicates a genetic susceptibility. This is amplified for Omicron (BA.1) and its sublineages BA.2 and BA.3. The antibody landscape was computationally investigated with the largest set of mAbs so far in the literature. From the 32 studied binders, groups of mAbs were identified from weak to strong binding affinities (e.g. S2K146). These mAbs with strong binding capacity and especially their combination are amenable to experimentation and clinical trials because of their high predicted binding affinities and possible neutralization potential for current known virus mutations and a universal coronavirus.Communicated by Ramaswamy H. Sarma.", "doi": "10.1080/07391102.2022.2095305", "pmid": "35815535", "labels": {"Category: Biochemistry": null, "Category: Omicron VoC": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-17T10:38:34.796Z", "modified": "2022-08-17T10:38:34.809Z"}, {"entity": "publication", "iuid": "976ccf16ac4f43fab2c6e9abaa215b17", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/976ccf16ac4f43fab2c6e9abaa215b17.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/976ccf16ac4f43fab2c6e9abaa215b17"}}, "title": "Willingness to Accept the COVID-19 Vaccine and Related Factors among Indian Adults: A Cross-Sectional Study.", "authors": [{"family": "Parthasarathi", "given": "Ashwaghosha", "initials": "A", "orcid": "0000-0002-7270-0247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c0a5e6837a421cbbb0314628ae7f24.json"}}, {"family": "Puvvada", "given": "Rahul Krishna", "initials": "RK", "orcid": "0000-0002-4813-9509", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b593c073cfa497c985cf5f897212910.json"}}, {"family": "Shankar", "given": "Malavika", "initials": "M", "orcid": "0000-0003-0462-3988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2a17e45d5b143728f26ac2d1cb8737c.json"}}, {"family": "Siddaiah", "given": "Jayaraj Biligere", "initials": "JB", "orcid": "0000-0001-6055-4580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c8166020c084a9f8508e74cfa0b2f25.json"}}, {"family": "Ganguly", "given": "Koustav", "initials": "K", "orcid": "0000-0001-8531-8154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58b2e0d7853a4b32920e54042e95061d.json"}}, {"family": "Upadhyay", "given": "Swapna", "initials": "S", "orcid": "0000-0003-4699-4082", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c98621d4161241dd9379dca3fa6e1bf1.json"}}, {"family": "Mahesh", "given": "Padukudru Anand", "initials": "PA", "orcid": "0000-0003-1632-5945", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70c3b10ccc334c4c8195556f07c862d0.json"}}], "type": "journal article", "published": "2022-07-08", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "7", "issn-l": null}, "abstract": "To achieve herd immunity to a disease, a large portion of the population needs to be vaccinated, which is possible only when there is broad acceptance of the vaccine within the community. Thus, policymakers need to understand how the general public will perceive the vaccine. This study focused on the degree of COVID-19 vaccine hesitancy and refusal and explored sociodemographic correlations that influence vaccine hesitancy and refusal. A cross-sectional online survey was conducted among the adult population of India. The survey consisted of basic demographic questions and questions from the Vaccination Attitudes Examination (VAX) Scale. Multinomial logistical regression was used to identify correlates of vaccine hesitancy and refusal. Of the 1582 people in the study, 9% refused to become vaccinated and 30.8% were hesitant. We found that both hesitancy and refusal predictors were nearly identical (lower socioeconomic status, female gender, and older age groups), except for three groups (subjects aged 45-64 years, those with approximate income &lt;10,000 INR/month, and those residing in rural households) that showed slightly higher odds of vaccine hesitancy than refusal. We need to address the underlying sociodemographic determinants and formulate public awareness programs to address specific subgroups that are at higher risk of rejecting the vaccine and convert those who are undecided or hesitant into those willing to accept the vaccine.", "doi": "10.3390/vaccines10071095", "pmid": "35891259", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "vaccines10071095"}, {"db": "pmc", "key": "PMC9317945"}], "notes": [], "created": "2022-08-12T08:35:37.008Z", "modified": "2022-08-12T08:35:37.236Z"}, {"entity": "publication", "iuid": "bd69868678954cacbb04b9ba22d688c8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bd69868678954cacbb04b9ba22d688c8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bd69868678954cacbb04b9ba22d688c8"}}, "title": "Susceptibility to SARS-Cov-2 infection and risk for severe COVID-19 in patients with prostate cancer on androgen deprivation therapy.", "authors": [{"family": "Gedeborg", "given": "Rolf", "initials": "R", "orcid": "0000-0002-8850-7863", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/234ef51ed7854efb8bbadc3ce35bf7d9.json"}}, {"family": "Loeb", "given": "Stacy", "initials": "S"}, {"family": "Styrke", "given": "Johan", "initials": "J"}, {"family": "Kiiski-Berggren", "given": "Ritva", "initials": "R"}, {"family": "Garmo", "given": "Hans", "initials": "H"}, {"family": "Stattin", "given": "P\u00e4r", "initials": "P"}], "type": "journal article", "published": "2022-07-08", "journal": {"title": "Int J Cancer", "issn": "1097-0215", "issn-l": null}, "abstract": "Androgen deprivation therapy (ADT) has been hypothesized to protect against COVID-19, but previous observational studies of men with prostate cancer on ADT have been inconsistent regarding mortality risk from coronavirus disease 2019 (COVID-19). Using data from the Prostate Cancer data Base Sweden (PCBaSe), we identified a cohort of 114 547 men with prevalent prostate cancer on the start of follow-up in February 2020, and followed them until 16 December 2020 to evaluate the association between ADT and time to test positive for COVID-19. Among men testing positive for COVID-19, we used regression analyses to estimate the association between ADT and risk of COVID-19-related hospital admission/death from any cause within 30 days of the positive test. In total, 1695 men with prostate cancer tested positive for COVID-19. In crude analyses, exposure to ADT was associated with a 3-fold increased risk of both testing positive for COVID-19 infection and subsequent hospital admission/death. Adjustment for age, comorbidity and prostate cancer risk category substantially attenuated the associations: HR 1.3 (95% CI: 1.1-1.5) for testing positive for COVID-19, and OR 1.4 (95% CI: 1.0-1.9) for risk of subsequent hospital admission/death. In conclusion, although these results suggest increased risks of a positive COVID-19 test, and COVID-19-related hospital admission/death in men on ADT, these findings are likely explained by confounding by old age, cancer-associated morbidity and other comorbidities being more prevalent in men on ADT, rather than a direct effect of the therapy.", "doi": "10.1002/ijc.34204", "pmid": "35802468", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9349425"}], "notes": [], "created": "2022-08-17T10:44:51.277Z", "modified": "2022-08-17T10:44:51.330Z"}, {"entity": "publication", "iuid": "c631eaa6b4ca46d28bcbdd61e322c012", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c631eaa6b4ca46d28bcbdd61e322c012.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c631eaa6b4ca46d28bcbdd61e322c012"}}, "title": "Multi-omics personalized network analyses highlight progressive disruption of central metabolism associated with COVID-19 severity.", "authors": [{"family": "Ambikan", "given": "Anoop T", "initials": "AT"}, {"family": "Yang", "given": "Hong", "initials": "H"}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Svensson Akusj\u00e4rvi", "given": "Sara", "initials": "S"}, {"family": "Gupta", "given": "Soham", "initials": "S"}, {"family": "Lourda", "given": "Magda", "initials": "M"}, {"family": "Sperk", "given": "Maike", "initials": "M"}, {"family": "Arif", "given": "Muhammad", "initials": "M"}, {"family": "Zhang", "given": "Cheng", "initials": "C"}, {"family": "Nordqvist", "given": "Hampus", "initials": "H"}, {"family": "Ponnan", "given": "Sivasankaran Munusamy", "initials": "SM"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Treutiger", "given": "Carl Johan", "initials": "CJ"}, {"family": "O'Mahony", "given": "Liam", "initials": "L"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A"}, {"family": "Benfeitas", "given": "Rui", "initials": "R"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "journal article", "published": "2022-07-08", "journal": {"title": "Cell Syst", "issn": "2405-4720", "issn-l": null}, "abstract": "The clinical outcome and disease severity in coronavirus disease 2019 (COVID-19) are heterogeneous, and the progression or fatality of the disease cannot be explained by a single factor like age or comorbidities. In this study, we used system-wide network-based system biology analysis using whole blood RNA sequencing, immunophenotyping by flow cytometry, plasma metabolomics, and single-cell-type metabolomics of monocytes to identify the potential determinants of COVID-19 severity at personalized and group levels. Digital cell quantification and immunophenotyping of the mononuclear phagocytes indicated a substantial role in coordinating the immune cells that mediate COVID-19 severity. Stratum-specific and personalized genome-scale metabolic modeling indicated monocarboxylate transporter family genes (e.g., SLC16A6), nucleoside transporter genes (e.g., SLC29A1), and metabolites such as \u03b1-ketoglutarate, succinate, malate, and butyrate could play a crucial role in COVID-19 severity. Metabolic perturbations targeting the central metabolic pathway (TCA cycle) can be an alternate treatment strategy in severe COVID-19.", "doi": "10.1016/j.cels.2022.06.006", "pmid": "35933992", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2405-4712(22)00276-9"}], "notes": [], "created": "2022-08-11T11:54:54.053Z", "modified": "2022-08-11T11:55:16.618Z"}, {"entity": "publication", "iuid": "8d87314fecdf428a9ebfa402ab51f02f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d87314fecdf428a9ebfa402ab51f02f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d87314fecdf428a9ebfa402ab51f02f"}}, "title": "The need for a food allergy educator program for allied healthcare professionals in Canada.", "authors": [{"family": "Protudjer", "given": "Jennifer L P", "initials": "JLP", "orcid": "0000-0002-3888-8688", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e35d8fddae04acbb44382b43acb0147.json"}}, {"family": "Venter", "given": "Carina", "initials": "C"}, {"family": "Groetch", "given": "Marion", "initials": "M"}, {"family": "Frykas", "given": "Tara Lynn Mary", "initials": "TLM"}, {"family": "Lidington", "given": "Jasmin", "initials": "J"}, {"family": "Kim", "given": "Harold", "initials": "H"}], "type": "letter", "published": "2022-07-07", "journal": {"title": "Allergy Asthma Clin Immunol", "issn": "1710-1484", "volume": "18", "issue": "1", "pages": "62", "issn-l": null}, "abstract": "Owing to a collaborative approach to patient care, and a paucity of allergists in Canada, there is a need to develop a food allergy educational program for allied health care professionals in Canada. Such programs already exist in the United States and Britain. Herein, we describe the outcomes of recent conference proceedings to inform the educational needs for such a program. As part of the 76th Annual Meeting of the Canadian Society of Allergy and Clinical Immunology (CSACI), held virtually due to the COVID-19 pandemic, we hosted a virtual workshop on the need for a food allergy educator program for Canadian allied health professionals. This workshop was co-developed with the CSACI and an industry partner, and featured allergy specialist dietitians. Attendance was open to all conference delegates, and to allied health professionals. As part of the registration process, registrants posed diverse food allergy-related questions, ranging from how to use an epinephrine autoinjector, to daily management and, how to cure food allergy. A national food allergy educator program will empower both allergy and non-allergy specialist healthcare professionals to appropriately counsel patients. This virtually-delivered program will begin to close a gap in healthcare access resulting from the geographic size of Canada, as it will enhance allied healthcare providers' confidence to provide evidence-based food allergy care appropriately for those with food allergy.", "doi": "10.1186/s13223-022-00701-2", "pmid": "35799220", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13223-022-00701-2"}, {"db": "pmc", "key": "PMC9261880"}], "notes": [], "created": "2022-08-17T10:45:57.211Z", "modified": "2022-08-17T10:45:57.264Z"}, {"entity": "publication", "iuid": "27960d2d50744d5d9cd3007dfcc0fc84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27960d2d50744d5d9cd3007dfcc0fc84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27960d2d50744d5d9cd3007dfcc0fc84"}}, "title": "Prevalence of and risk factors for depression, anxiety, and stress in non-hospitalized asymptomatic and mild COVID-19 patients in East Java province, Indonesia.", "authors": [{"family": "Lusida", "given": "Michael Austin Pradipta", "initials": "MAP"}, {"family": "Salamah", "given": "Sovia", "initials": "S", "orcid": "0000-0002-4815-8929", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fcc2cebe9fcf490f992ad65e73622fc3.json"}}, {"family": "Jonatan", "given": "Michael", "initials": "M"}, {"family": "Wiyogo", "given": "Illona Okvita", "initials": "IO"}, {"family": "Asyari", "given": "Claudia Herda", "initials": "CH"}, {"family": "Ali", "given": "Nurarifah Destianizar", "initials": "ND"}, {"family": "Asmara", "given": "Jose", "initials": "J"}, {"family": "Wahyuningtyas", "given": "Ria Indah", "initials": "RI"}, {"family": "Triyono", "given": "Erwin Astha", "initials": "EA"}, {"family": "Ratnadewi", "given": "Ni Kadek", "initials": "NK"}, {"family": "Irzaldy", "given": "Abyan", "initials": "A"}, {"family": "Alkaff", "given": "Firas Farisi", "initials": "FF"}], "type": "journal article", "published": "2022-07-07", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "7", "pages": "e0270966", "issn-l": "1932-6203"}, "abstract": "Despite abundant data on mental health during the COVID-19 pandemic, 3 important knowledge gaps continue to exist, i.e., 1) studies from low-/middle income countries (LMICs); 2) studies in the later period of the COVID-19 pandemic; and 3) studies on non-hospitalized asymptomatic and mild COVID-19 patients. To address the knowledge gaps, we assessed the prevalence of and the risk factors for mental health symptoms among non-hospitalized asymptomatic and mild COVID-19 patients in one LMIC (Indonesia) during the later period of the pandemic.\n\nThis cross-sectional study was conducted in September 2020 in East Java province, Indonesia. Study population consisted of non-hospitalized asymptomatic and mild COVID-19 patients who were diagnosed based on reverse transcriptase-polymerase chain reaction results from nasopharyngeal swab. Mental health symptoms were evaluated using the Depression Anxiety Stress Scale-21.\n\nFrom 778 non-hospitalized asymptomatic and mild COVID-19 patients, 608 patients were included in the analysis. Patients' median age was 35 years old and 61.2% were male. Of these, 22 (3.6%) reported symptoms of depression, 87 (14.3%) reported symptoms of anxiety, and 48 (7.9%) reported symptoms of stress. Multivariate logistic regression analysis showed that females were more likely to report symptoms of stress (adjusted odds ratio (aOR) = 1.98, p-value = 0.028); healthcare workers were more likely to report symptoms of depression and anxiety (aOR = 5.57, p-value = 0.002 and aOR = 2.92, p-value = 0.014, respectively); and those with a recent history of self-quarantine were more likely to report symptoms of depression and stress (aOR 5.18, p = 0.004 and aOR = 1.86, p = 0.047, respectively).\n\nThe reported prevalence of mental health symptoms, especially depression, was relatively low among non-hospitalized asymptomatic and mild COVID-19 patients during the later period of the COVID-19 pandemic in East Java province, Indonesia. In addition, several risk factors have been identified.", "doi": "10.1371/journal.pone.0270966", "pmid": "35797394", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-21429"}, {"db": "pmc", "key": "PMC9262201"}], "notes": [], "created": "2022-08-17T10:46:19.639Z", "modified": "2022-08-17T10:46:58.176Z"}, {"entity": "publication", "iuid": "7e9ab7e05e884d09a7c7cc6bf6e16f4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e9ab7e05e884d09a7c7cc6bf6e16f4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e9ab7e05e884d09a7c7cc6bf6e16f4d"}}, "title": "Vaccine Safety Surveillance Using Routinely Collected Healthcare Data-An Empirical Evaluation of Epidemiological Designs.", "authors": [{"family": "Schuemie", "given": "Martijn J", "initials": "MJ"}, {"family": "Arshad", "given": "Faaizah", "initials": "F"}, {"family": "Pratt", "given": "Nicole", "initials": "N"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Lai", "given": "Lana Y H", "initials": "LYH"}, {"family": "Li", "given": "Xintong", "initials": "X"}, {"family": "Fortin", "given": "Stephen", "initials": "S"}, {"family": "Minty", "given": "Evan", "initials": "E"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}], "type": "journal article", "published": "2022-07-06", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "issn-l": "1663-9812", "volume": "13", "issue": null, "pages": "893484"}, "abstract": "Background: Routinely collected healthcare data such as administrative claims and electronic health records (EHR) can complement clinical trials and spontaneous reports to detect previously unknown risks of vaccines, but uncertainty remains about the behavior of alternative epidemiologic designs to detect and declare a true risk early. Methods: Using three claims and one EHR database, we evaluate several variants of the case-control, comparative cohort, historical comparator, and self-controlled designs against historical vaccinations using real negative control outcomes (outcomes with no evidence to suggest that they could be caused by the vaccines) and simulated positive control outcomes. Results: Most methods show large type 1 error, often identifying false positive signals. The cohort method appears either positively or negatively biased, depending on the choice of comparator index date. Empirical calibration using effect-size estimates for negative control outcomes can bring type 1 error closer to nominal, often at the cost of increasing type 2 error. After calibration, the self-controlled case series (SCCS) design most rapidly detects small true effect sizes, while the historical comparator performs well for strong effects. Conclusion: When applying any method for vaccine safety surveillance we recommend considering the potential for systematic error, especially due to confounding, which for many designs appears to be substantial. Adjusting for age and sex alone is likely not sufficient to address differences between vaccinated and unvaccinated, and for the cohort method the choice of index date is important for the comparability of the groups. Analysis of negative control outcomes allows both quantification of the systematic error and, if desired, subsequent empirical calibration to restore type 1 error to its nominal value. In order to detect weaker signals, one may have to accept a higher type 1 error.", "doi": "10.3389/fphar.2022.893484", "pmid": "35873596", "labels": {"Category: Vaccines": null, "Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9299244"}, {"db": "pii", "key": "893484"}], "notes": [], "created": "2023-01-13T09:56:38.927Z", "modified": "2023-01-13T10:02:34.231Z"}, {"entity": "publication", "iuid": "5a2ca13f8c3a4714b322dc44beac84e5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5a2ca13f8c3a4714b322dc44beac84e5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5a2ca13f8c3a4714b322dc44beac84e5"}}, "title": "The COVID-19 Pandemic and Adolescents' Psychological Distress: A Multinational Cross-Sectional Study.", "authors": [{"family": "Nguyen", "given": "Hang T M", "initials": "HTM"}, {"family": "Nguyen", "given": "Hoang V", "initials": "HV"}, {"family": "Zouini", "given": "Btissame", "initials": "B", "orcid": "0000-0002-9692-2397", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8935bc90d78143139467d7cfe522f70a.json"}}, {"family": "Senhaji", "given": "Meftaha", "initials": "M", "orcid": "0000-0002-1604-4038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96559d09177a4a34802d08bad5369ca0.json"}}, {"family": "Bador", "given": "Kourosh", "initials": "K", "orcid": "0000-0001-9163-6837", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a3c65199d6449119963e936c3605aca.json"}}, {"family": "Meszaros", "given": "Zsuzsa Szombathyne", "initials": "ZS", "orcid": "0000-0003-2775-0453", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb8155e02af84f868e4b8e58f8e6d73d.json"}}, {"family": "Stevanovic", "given": "Dejan", "initials": "D", "orcid": "0000-0001-8236-5246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fd2d9e3b1114cf5bd2a89e5ab0dc766.json"}}, {"family": "Kerekes", "given": "N\u00f3ra", "initials": "N", "orcid": "0000-0002-8854-0399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/175ef55a6f3b45909a0a76b55cc0e4b3.json"}}], "type": "journal article", "published": "2022-07-06", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "14", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has continued for more than two years, and the impact of this pandemic on mental health has become one of the most important research topics in psychiatry and psychology. The aim of the present study was to assess psychological distress in adolescents across five countries (Sweden, Morocco, Serbia, Vietnam, and the United States of America) during the COVID-19 pandemic.\n\nUsing nonparametric analyses we examined the impact of COVID-19 on distress, measured by the Brief Symptom Inventory, in a sample of 4670 adolescents.\n\nOur results showed that the association between the COVID-19 impact and psychological distress in adolescents' lives was positive and moderate in Morocco and Serbia, positive and weak in Vietnam and the United States of America, and negative and weak in Sweden. We also found that female adolescents reported higher distress levels than male adolescents.\n\nCOVID-19 impacted adolescents and their psychological distress differently depending on their residence.", "doi": "10.3390/ijerph19148261", "pmid": "35886118", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19148261"}, {"db": "pmc", "key": "PMC9317312"}], "notes": [], "created": "2022-08-12T08:36:15.802Z", "modified": "2022-08-12T08:36:15.959Z"}, {"entity": "publication", "iuid": "5f8f810d6ce14398a6309fbb26311dca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f8f810d6ce14398a6309fbb26311dca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f8f810d6ce14398a6309fbb26311dca"}}, "title": "Fighting social isolation in times of pandemic COVID-19: the role of video calls for older hospitalized patients.", "authors": [{"family": "D\u00fcrst", "given": "Anne-V\u00e9ronique", "initials": "AV"}, {"family": "Graf", "given": "Christophe E", "initials": "CE"}, {"family": "Ruggiero", "given": "Carmelinda", "initials": "C"}, {"family": "Zekry", "given": "Dina", "initials": "D"}, {"family": "Boccardi", "given": "Virginia", "initials": "V"}, {"family": "Monney", "given": "Lauretta", "initials": "L"}, {"family": "Joss", "given": "Isaline", "initials": "I"}, {"family": "Vuilloud", "given": "Karine", "initials": "K"}, {"family": "Vespignani", "given": "Giulia", "initials": "G"}, {"family": "Bosshard", "given": "Wanda", "initials": "W"}, {"family": "Mecocci", "given": "Patrizia", "initials": "P"}, {"family": "Bula", "given": "Christophe J", "initials": "CJ"}, {"family": "D'Amelio", "given": "Patrizia", "initials": "P", "orcid": "0000-0002-4467-8337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c9b0d8ed88f48339d678ee72467a97d.json"}}], "type": "journal article", "published": "2022-07-06", "journal": {"title": "Aging Clin Exp Res", "issn": "1720-8319", "issn-l": "1594-0667"}, "abstract": "Loneliness and social isolation are associated with anxiety and psychological discomfort, especially amongst the oldest and fragile persons.\n\nSILVER evaluates the acceptance of video calls by old hospitalized patients and their relatives during the ban on visits due to the COVID-19. Moreover, SILVER evaluates if the use of different communication technology is associated with different outcomes in terms of anxiety, fear of self and of others' death and mood.\n\nSILVER is an observational multicentre study. Patients hospitalized in two geriatric units in Switzerland and in one orthogeriatric unit in Italy and their relatives were enrolled. Participants can freely choose to use phone or video calls and were evaluated over a week. We measured anxiety, fear of death and mood at baseline and at the end of the study with standard scales. The use of video or phone calls was associated to a change in these parameters by two-way ANOVA for repeated measures.\n\nSixty-four patients and relatives were enrolled, 26.5% used phone calls and 73.5% video calls. The use of video calls was associated with a reduction in anxiety and fear of death in patients and relatives as compared to participants using phone calls.\n\nOld patients and their relatives accepted and appreciated the use of video calls during hospitalization; moreover, participant using video calls appears to be less anxious and less afraid of death.\n\nVideo calls may be a useful communication tool for hospitalized older patients to keep social relationships with relatives and reduce their anxiety and fear of death.\n\nRetrospectively registered on 1st September 2021 in ClinicalTrials.gov (NCT05000099).", "doi": "10.1007/s40520-022-02188-8", "pmid": "35794314", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40520-022-02188-8"}, {"db": "pmc", "key": "PMC9261146"}, {"db": "ClinicalTrials.gov", "key": "NCT05000099"}], "notes": [], "created": "2022-08-17T10:47:20.389Z", "modified": "2022-08-17T10:47:20.446Z"}, {"entity": "publication", "iuid": "9f28d971c8194812a6292e5c9980d210", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f28d971c8194812a6292e5c9980d210.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f28d971c8194812a6292e5c9980d210"}}, "title": "Experiences of How Health and Lifestyle among Individuals with Knee Pain Have Been Influenced during the COVID-19 Pandemic, a HALLOA Study.", "authors": [{"family": "Sunesson", "given": "Evelina", "initials": "E"}, {"family": "Sylwander", "given": "Charlotte", "initials": "C"}, {"family": "Haglund", "given": "Emma", "initials": "E"}, {"family": "Andersson", "given": "Maria L E", "initials": "MLE", "orcid": "0000-0002-0217-5029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c44d890721546b4b14925b6cc9dc805.json"}}, {"family": "Larsson", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-4341-660X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65ac6fdb68864c928da7f0ad3f2d8b8d.json"}}], "type": "journal article", "published": "2022-07-06", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "14", "issn-l": null}, "abstract": "The COVID-19 pandemic has affected the health and lifestyles of both the general population and of vulnerable groups. Individuals with knee pain are recommended to lead an active lifestyle to relieve pain but find it difficult to maintain health and lifestyle compared to the general population due to the cause of chronic pain, impaired physical function, and a diminished quality of life. This study aimed to explore experiences of how health and lifestyle among individuals with knee pain have been influenced during the COVID-19 pandemic. Interviews (n = 19) were conducted in 2021 and analysed with qualitative content analysis. The results showed how individuals with knee pain adjusted their behaviour and revalued their life to maintain health and lifestyle during COVID-19. Adjusted behaviours emerged, such as spending more time at home, becoming digital, and spending more time outdoors, while revaluing life emerged as having a positive outlook on life and sharing responsibility. In conclusion, behaviour was adjusted, and life revalued to manage health and lifestyle during the pandemic. However, the findings are probably similar to the general population, i.e., individuals with knee pain live similar lives as the general population despite knee pain. The results may contribute to alternative ways of maintaining health and lifestyle in various vulnerable groups and may be applied in situations other than the pandemic.", "doi": "10.3390/ijerph19148255", "pmid": "35886110", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19148255"}, {"db": "pmc", "key": "PMC9315972"}], "notes": [], "created": "2022-08-12T08:36:38.200Z", "modified": "2022-08-12T08:36:38.309Z"}, {"entity": "publication", "iuid": "fcf104220f5242e1a52824105e8f0c05", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fcf104220f5242e1a52824105e8f0c05.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fcf104220f5242e1a52824105e8f0c05"}}, "title": "Dengue Infection - Recent Advances in Disease Pathogenesis in the Era of COVID-19.", "authors": [{"family": "Yong", "given": "Yean Kong", "initials": "YK"}, {"family": "Wong", "given": "Won Fen", "initials": "WF"}, {"family": "Vignesh", "given": "Ramachandran", "initials": "R"}, {"family": "Chattopadhyay", "given": "Indranil", "initials": "I"}, {"family": "Velu", "given": "Vijayakumar", "initials": "V"}, {"family": "Tan", "given": "Hong Yien", "initials": "HY"}, {"family": "Zhang", "given": "Ying", "initials": "Y"}, {"family": "Larsson", "given": "Marie", "initials": "M"}, {"family": "Shankar", "given": "Esaki M", "initials": "EM"}], "type": "journal article", "published": "2022-07-06", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "13", "pages": "889196", "issn-l": "1664-3224"}, "abstract": "The dynamics of host-virus interactions, and impairment of the host's immune surveillance by dengue virus (DENV) serotypes largely remain ambiguous. Several experimental and preclinical studies have demonstrated how the virus brings about severe disease by activating immune cells and other key elements of the inflammatory cascade. Plasmablasts are activated during primary and secondary infections, and play a determinative role in severe dengue. The cross-reactivity of DENV immune responses with other flaviviruses can have implications both for cross-protection and severity of disease. The consequences of a cross-reactivity between DENV and anti-SARS-CoV-2 responses are highly relevant in endemic areas. Here, we review the latest progress in the understanding of dengue immunopathogenesis and provide suggestions to the development of target strategies against dengue.", "doi": "10.3389/fimmu.2022.889196", "pmid": "35874775", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC9299105"}], "notes": [], "created": "2022-08-12T08:39:51.534Z", "modified": "2023-06-19T15:34:07.885Z"}, {"entity": "publication", "iuid": "94bdb76111d34f3f9a8895e350216a9a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/94bdb76111d34f3f9a8895e350216a9a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/94bdb76111d34f3f9a8895e350216a9a"}}, "title": "Comparison of drug prescribing before and during the COVID-19 pandemic: A cross-national European study.", "authors": [{"family": "Selke Krulichov\u00e1", "given": "Iva", "initials": "I", "orcid": "0000-0002-6815-0780", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b42258b4310445be9971d83f1863460e.json"}}, {"family": "Selke", "given": "Gisbert W", "initials": "GW", "orcid": "0000-0002-9614-9875", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4960af9c72b4042b9ec3dcd3436d1b2.json"}}, {"family": "Bennie", "given": "Marion", "initials": "M", "orcid": "0000-0002-4046-629X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d920bb014a2414b8171cc8b88abee31.json"}}, {"family": "Hajiebrahimi", "given": "Mohammadhossein", "initials": "M", "orcid": "0000-0001-8118-4988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8338602bdf4d40ffb25713e73b1fc719.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "F\u00fcrst", "given": "Jurij", "initials": "J"}, {"family": "Garuolien\u0117", "given": "Kristina", "initials": "K", "orcid": "0000-0001-7910-0108", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d0b8225059ef405383282d4d9cf02a2d.json"}}, {"family": "Poluzzi", "given": "Elisabetta", "initials": "E", "orcid": "0000-0002-7209-0426", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74229bb087504277a7d2befc7def7291.json"}}, {"family": "Slab\u00fd", "given": "Juraj", "initials": "J"}, {"family": "Yahni", "given": "Corinne Zara", "initials": "CZ", "orcid": "0000-0002-6831-2233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3118450a58744b3e9088d8d2ceb88c66.json"}}, {"family": "Altini", "given": "Mattia", "initials": "M", "orcid": "0000-0002-1809-184X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fdda0cf8e1e741a6be5c7e574d2de956.json"}}, {"family": "Fantini", "given": "Maria Pia", "initials": "MP", "orcid": "0000-0002-3257-6552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2dc69b69cb434e8ea5b7cb2a9267b6f2.json"}}, {"family": "Ko\u010d\u00ed", "given": "V\u00e1clav", "initials": "V"}, {"family": "McTaggart", "given": "Stuart", "initials": "S", "orcid": "0000-0001-6060-9019", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5502fb30f15c465bb0301428f8a0e2ef.json"}}, {"family": "Pontes", "given": "Caridad", "initials": "C", "orcid": "0000-0002-3274-6048", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bb9e906d55141a58f1379cfa81843cf.json"}}, {"family": "Reno", "given": "Chiara", "initials": "C", "orcid": "0000-0002-7933-2141", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9d5f681fdbe4057b795a9a0e73fe282.json"}}, {"family": "Rosa", "given": "Simona", "initials": "S"}, {"family": "Pedrola", "given": "Marta Turu", "initials": "MT", "orcid": "0000-0001-6957-3155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b0ea18522e843ca954888de7cfff1c2.json"}}, {"family": "Udovi\u010d", "given": "Mitja", "initials": "M"}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0003-0531-2516", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4911f8524d634e928a77f67c40e1610d.json"}}], "type": "journal article", "published": "2022-07-06", "journal": {"title": "Pharmacoepidemiol Drug Saf", "issn": "1099-1557", "issn-l": null}, "abstract": "The COVID-19 pandemic had an impact on health care, with disruption to routine clinical care. Our aim was to describe changes in prescription drugs dispensing in the primary and outpatient sectors during the first year of the pandemic across Europe.\n\nWe used routine administrative data on dispensed medicines in eight European countries (five whole countries, three represented by one region each) from January 2017 to March 2021 to compare the first year of the COVID-19 pandemic with the preceding 3 years.\n\nIn the 10 therapeutic subgroups with the highest dispensed volumes across all countries/regions the relative changes between the COVID-19 period and the year before were mostly of a magnitude similar to changes between previous periods. However, for drugs for obstructive airway diseases the changes in the COVID-19 period were stronger in several countries/regions. In all countries/regions a decrease in dispensed DDDs of antibiotics for systemic use (from -39.4% in Romagna to -14.2% in Scotland) and nasal preparations (from -34.4% in Lithuania to -5.7% in Sweden) was observed. We observed a stockpiling effect in the total market in March 2020 in six countries/regions. In Czechia the observed increase was not significant and in Slovenia volumes increased only after the end of the first lockdown. We found an increase in average therapeutic quantity per pack dispensed, which, however, exceeded 5% only in Slovenia, Germany, and Czechia.\n\nThe findings from this first European cross-national comparison show a substantial decrease in dispensed volumes of antibiotics for systemic use in all countries/regions. The results also indicate that the provision of medicines for common chronic conditions was mostly resilient to challenges faced during the pandemic. However, there were notable differences between the countries/regions for some therapeutic areas.", "doi": "10.1002/pds.5509", "pmid": "35791700", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9350215"}], "notes": [], "created": "2022-08-17T10:47:43.816Z", "modified": "2022-08-17T10:47:44.287Z"}, {"entity": "publication", "iuid": "97a4619db82b4311bbd564a3a54b3cd5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/97a4619db82b4311bbd564a3a54b3cd5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/97a4619db82b4311bbd564a3a54b3cd5"}}, "title": "Scandinavian Nurses' Use of Social Media during the COVID-19 Pandemic-A Berger and Luckman Inspired Analysis of a Qualitative Interview Study.", "authors": [{"family": "Glasdam", "given": "Stinne", "initials": "S", "orcid": "0000-0002-0893-3054", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c56787745d04e05ad85e53ce8df6061.json"}}, {"family": "Jacobsen", "given": "Frode F", "initials": "FF"}, {"family": "Hybholt", "given": "Lisbeth", "initials": "L", "orcid": "0000-0002-9764-8940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11f4283601794ccd903ead36c41ce8a3.json"}}, {"family": "Stjernsw\u00e4rd", "given": "Sigrid", "initials": "S", "orcid": "0000-0002-7152-9206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cda8ee3ae8564252aa6ffe2ab219ada8.json"}}], "type": "journal article", "published": "2022-07-05", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "volume": "10", "issue": "7", "issn-l": null}, "abstract": "There is a knowledge gap about nurses' use of social media in relation to and during the COVID-19 pandemic, which demands the upholding of a physical distance to other people, including patients and their relatives. The study aims to explore how nurses in the Scandinavian countries used social media for professional purposes in relation to the first 15 months of the COVID-19 pandemic. Qualitative, semi-structured interviews with 30 nurses in three Scandinavian countries (Denmark, Norway, and Sweden) were conducted. Thematic analyses were made, methodically inspired by Braun and Clarke, and theoretically inspired by Berger and Luckmann's theory about the construction of social reality. The Standards for Reporting Qualitative Research (SRQR) checklist was used. The results showed that social media was a socialisation tool for establishing new routines in clinical practice. Virtual meeting places supported collective understandings of a specific COVID-19 'reality' and 'knowledge' amongst nurses, with the pandemic bringing to the fore the issue of e-professionalism among nurses relating to their clinical practice. However, social media and virtual education were not commonly used in patient contacts. Further, nurses attempted a re-socialisation of the public to proper COVID-19 behaviour through social media. Moreover, blurred boundaries between acting as a private individual and a professional nurse were identified, where ethics of the nursing profession extended to nurses' private lives.", "doi": "10.3390/healthcare10071254", "pmid": "35885781", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "healthcare10071254"}, {"db": "pmc", "key": "PMC9321788"}], "notes": [], "created": "2022-08-12T08:36:58.308Z", "modified": "2022-08-12T08:37:41.053Z"}, {"entity": "publication", "iuid": "1a8b450f998f4242836f0c0e674bfd5c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1a8b450f998f4242836f0c0e674bfd5c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1a8b450f998f4242836f0c0e674bfd5c"}}, "title": "Impact of the COVID-19 pandemic on hernia surgery in a Swedish healthcare region: a population-based cohort study.", "authors": [{"family": "Kollatos", "given": "Christos", "initials": "C", "orcid": "0000-0001-5601-1794", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0c0f32a7ddd4310a7f83271538c234f.json"}}, {"family": "Hanna", "given": "Sarmad", "initials": "S"}, {"family": "Sandblom", "given": "Gabriel", "initials": "G"}], "type": "journal article", "published": "2022-07-05", "journal": {"title": "BMC Surg", "issn": "1471-2482", "volume": "22", "issue": "1", "pages": "260", "issn-l": null}, "abstract": "Swedish healthcare has been reorganised during the COVID-19 pandemic, affecting the availability of surgery for benign conditions. The aim of this study was to determine the effects of COVID-19 on emergency and elective hernia surgery in a Swedish healthcare region.\n\nUsing procedure codes, data from inguinal and ventral hernia procedures performed at the three hospitals in J\u00f6nk\u00f6ping Region, Sweden, from March 1st 2019 to January 31st 2021, were retrieved from a medical database. The cohort was divided into two groups: the COVID-19 group (March 1st 2020-January 31st 2021) and the control group (March 1st 2019-January 31st 2020). Demographic and preoperative data, hernia type, perioperative findings, and type of surgery were analysed.\n\nA total 1329 patients underwent hernia surgery during the study period; 579 were operated during the COVID-19 period and 750 during the control period. The number of emergency ventral hernia repairs increased during the COVID-19 period, but no difference in inguinal hernia repair rate was seen. The characteristics of patients that underwent hernia repair were similar in the two groups. Moreover, the decrease in elective ventral hernia repair rate during the COVID-19 period did not result in a higher risk for strangulation.\n\nThere is no evidence to suggest that the decrease in the number of elective ventral hernia repairs during the COVID-19 period had any impact on the risk for strangulation. Indications for surgery in patients with a symptomatic ventral or inguinal hernia should be carefully evaluated. Studies with greater power and longer follow-up are needed to gain a full understanding of the effects of the COVID-19 pandemic on hernia surgery.", "doi": "10.1186/s12893-022-01698-6", "pmid": "35790926", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12893-022-01698-6"}, {"db": "pmc", "key": "PMC9255440"}], "notes": [], "created": "2022-08-17T13:07:46.085Z", "modified": "2022-08-17T13:08:18.855Z"}, {"entity": "publication", "iuid": "4b3303eb8cc34f53b1dfd91a3ae8dda9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b3303eb8cc34f53b1dfd91a3ae8dda9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b3303eb8cc34f53b1dfd91a3ae8dda9"}}, "title": "Highly perturbed genes and hub genes associated with type 2 diabetes in different tissues of adult humans: a bioinformatics analytic workflow.", "authors": [{"family": "De Silva", "given": "Kushan", "initials": "K"}, {"family": "Demmer", "given": "Ryan T", "initials": "RT"}, {"family": "J\u00f6nsson", "given": "Daniel", "initials": "D"}, {"family": "Mousa", "given": "Aya", "initials": "A"}, {"family": "Forbes", "given": "Andrew", "initials": "A"}, {"family": "Enticott", "given": "Joanne", "initials": "J"}], "type": "journal article", "published": "2022-07-05", "journal": {"title": "Funct Integr Genomics", "issn": "1438-7948", "issn-l": null}, "abstract": "Type 2 diabetes (T2D) has a complex etiology which is not yet fully elucidated. The identification of gene perturbations and hub genes of T2D may deepen our understanding of its genetic basis. We aimed to identify highly perturbed genes and hub genes associated with T2D via an extensive bioinformatics analytic workflow consisting of five steps: systematic review of Gene Expression Omnibus and associated literature; identification and classification of differentially expressed genes (DEGs); identification of highly perturbed genes via meta-analysis; identification of hub genes via network analysis; and downstream analysis of highly perturbed genes and hub genes. Three meta-analytic strategies, random effects model, vote-counting approach, and p value combining approach, were applied. Hub genes were defined as those nodes having above-average betweenness, closeness, and degree in the network. Downstream analyses included gene ontologies, Kyoto Encyclopedia of Genes and Genomes pathways, metabolomics, COVID-19-related gene sets, and Genotype-Tissue Expression profiles. Analysis of 27 eligible microarrays identified 6284 DEGs (4592 downregulated and 1692 upregulated) in four tissue types. Tissue-specific gene expression was significantly greater than tissue non-specific (shared) gene expression. Analyses revealed 79 highly perturbed genes and 28 hub genes. Downstream analyses identified enrichments of shared genes with certain other diabetes phenotypes; insulin synthesis and action-related pathways and metabolomics; mechanistic associations with apoptosis and immunity-related pathways; COVID-19-related gene sets; and cell types demonstrating over- and under-expression of marker genes of T2D. Our approach provided valuable insights on T2D pathogenesis and pathophysiological manifestations. Broader utility of this pipeline beyond T2D is envisaged.", "doi": "10.1007/s10142-022-00881-5", "pmid": "35788821", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10142-022-00881-5"}, {"db": "pmc", "key": "PMC9255467"}], "notes": [], "created": "2022-08-17T13:09:22.836Z", "modified": "2022-08-17T13:09:50.558Z"}, {"entity": "publication", "iuid": "eb17fcce8461418a8c60d3476e72b39f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb17fcce8461418a8c60d3476e72b39f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb17fcce8461418a8c60d3476e72b39f"}}, "title": "Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency.", "authors": [{"family": "Campbell", "given": "Tessa Mollie", "initials": "TM", "orcid": "0000-0002-7737-2123", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8acc313f985d4822bf652289f0eb1b22.json"}}, {"family": "Liu", "given": "Zhiyong", "initials": "Z", "orcid": "0000-0001-6473-348X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d7b2869a5874679b1b6fdccade088a2.json"}}, {"family": "Zhang", "given": "Qian", "initials": "Q", "orcid": "0000-0002-9040-3289", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/341c0cb0fa7d41448e55344c82d68358.json"}}, {"family": "Moncada-Velez", "given": "Marcela", "initials": "M", "orcid": "0000-0002-3073-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c543a8539a6430b8ff5cd9cf5875bf9.json"}}, {"family": "Covill", "given": "Laura E", "initials": "LE", "orcid": "0000-0002-5086-9877", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12f826545b264c1d855a84c5fc3b73bd.json"}}, {"family": "Zhang", "given": "Peng", "initials": "P", "orcid": "0000-0002-6129-567X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ff2f497bd7841b7994dbdf8d2369a4e.json"}}, {"family": "Alavi Darazam", "given": "Ilad", "initials": "I", "orcid": "0000-0002-4440-335X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e747bb463d434cc8b586845f4609391e.json"}}, {"family": "Bastard", "given": "Paul", "initials": "P", "orcid": "0000-0002-5926-8437", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e3388c840d04a25824530a9bf999f01.json"}}, {"family": "Bizien", "given": "Lucy", "initials": "L", "orcid": "0000-0001-9163-9122", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ffde5891cfed41db9dc0265155576cc4.json"}}, {"family": "Bucciol", "given": "Giorgia", "initials": "G", "orcid": "0000-0001-5004-0738", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fde316a981d84407a32dca71fd6f39ba.json"}}, {"family": "Lind Enoksson", "given": "Sara", "initials": "S", "orcid": "0000-0002-0359-8824", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59b33d03efb841f89d3aa2d89618ff6c.json"}}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E"}, {"family": "Karabela", "given": "\u015eemsi Nur", "initials": "\u015eN", "orcid": "0000-0002-7358-9157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c50d261245743539a5813daffcaab72.json"}}, {"family": "Khan", "given": "Taushif", "initials": "T", "orcid": "0000-0002-7917-8965", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b38d5757c43448c3bf12179d4daaf6c2.json"}}, {"family": "Kendir-Demirkol", "given": "Yasemin", "initials": "Y", "orcid": "0000-0003-2562-3004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a31edf9803d748fea64cfd524f2cfe45.json"}}, {"family": "Arias", "given": "Andres Augusto", "initials": "AA", "orcid": "0000-0002-9478-8403", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd8725e3260449938376f721b1202424.json"}}, {"family": "Mansouri", "given": "Davood", "initials": "D", "orcid": "0000-0002-0564-8282", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5bd15b582b93449aaf4dc5cf76428ae9.json"}}, {"family": "Marits", "given": "Per", "initials": "P", "orcid": "0000-0003-2439-5687", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11e1e104844f49e3acadd1c573578941.json"}}, {"family": "Marr", "given": "Nico", "initials": "N", "orcid": "0000-0002-1927-7072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6b7acf92c1041aca93130dc97b1d2f8.json"}}, {"family": "Migeotte", "given": "Isabelle", "initials": "I", "orcid": "0000-0002-8972-8211", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43cd209fd75647fcbe0bd85bc8b94b19.json"}}, {"family": "Moens", "given": "Leen", "initials": "L", "orcid": "0000-0002-5347-6526", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49147a953e1c4721bd0181e5d0a3dafb.json"}}, {"family": "Ozcelik", "given": "Tayfun", "initials": "T", "orcid": "0000-0001-5937-1082", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6665d35db77044aa847a5f394332bb86.json"}}, {"family": "Pellier", "given": "Isabelle", "initials": "I", "orcid": "0000-0002-7988-4712", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/da3596d83f504628a6f4d86150486cbe.json"}}, {"family": "Sendel", "given": "Anton", "initials": "A", "orcid": "0000-0003-4410-3418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e1d9e27c0334858b83da8fdeeac0f9b.json"}}, {"family": "Shahrooei", "given": "Mohammad", "initials": "M", "orcid": "0000-0002-4974-3441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/165bdcfd868e4bd6b7adf371b9d4124f.json"}}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE", "orcid": "0000-0003-1907-3392", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26a3bf24bd044fbda8ffa0c89974bdfe.json"}}, {"family": "Vandernoot", "given": "Isabelle", "initials": "I", "orcid": "0000-0001-8084-7858", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b424cad4625b4b1eb4d901e206f0aa72.json"}}, {"family": "Willekens", "given": "Karen", "initials": "K", "orcid": "0000-0003-2338-5778", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/946e9a2c438f46f5ac816e827c5d8248.json"}}, {"family": "COVID Human Genetic Effort", "given": "", "initials": ""}, {"family": "Bergman", "given": "Peter", "initials": "P", "orcid": "0000-0003-3306-3713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15b7290255814a7b9a1a97c3cdb2fc26.json"}}, {"family": "Abel", "given": "Laurent", "initials": "L", "orcid": "0000-0001-7016-6493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fd6c4593c8c492a8dad8e49cb7a832a.json"}}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5369fe152ac94b5a81d4f913d85940a7.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL", "orcid": "0000-0002-7782-4169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1aca66ab7c39465faf2de03fa8a6722f.json"}}, {"family": "Meyts", "given": "Isabelle", "initials": "I", "orcid": "0000-0003-1214-0302", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a5399449f4c4d338b683632944008fb.json"}}, {"family": "Bryceson", "given": "Yenan T", "initials": "YT", "orcid": "0000-0002-7783-9934", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e66a62e856374a029c8446e863894afe.json"}}], "type": "journal article", "published": "2022-07-04", "journal": {"title": "J Exp Med", "issn": "1540-9538", "volume": "219", "issue": "7", "issn-l": null}, "abstract": "Autosomal recessive IRF7 deficiency was previously reported in three patients with single critical influenza or COVID-19 pneumonia episodes. The patients' fibroblasts and plasmacytoid dendritic cells produced no detectable type I and III IFNs, except IFN-\u03b2. Having discovered four new patients, we describe the genetic, immunological, and clinical features of seven IRF7-deficient patients from six families and five ancestries. Five were homozygous and two were compound heterozygous for IRF7 variants. Patients typically had one episode of pulmonary viral disease. Age at onset was surprisingly broad, from 6 mo to 50 yr (mean age 29 yr). The respiratory viruses implicated included SARS-CoV-2, influenza virus, respiratory syncytial virus, and adenovirus. Serological analyses indicated previous infections with many common viruses. Cellular analyses revealed strong antiviral immunity and expanded populations of influenza- and SARS-CoV-2-specific memory CD4+ and CD8+ T cells. IRF7-deficient individuals are prone to viral infections of the respiratory tract but are otherwise healthy, potentially due to residual IFN-\u03b2 and compensatory adaptive immunity.", "doi": "10.1084/jem.20220202", "pmid": "35670811", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "213267"}], "notes": [], "created": "2022-06-20T19:32:16.154Z", "modified": "2022-06-20T19:32:16.705Z"}, {"entity": "publication", "iuid": "69969fa1ecae46f88d17372796e6b72c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69969fa1ecae46f88d17372796e6b72c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69969fa1ecae46f88d17372796e6b72c"}}, "title": "A qualitative study on mothers' experiences attending an online infant massage class: \"It is funny! I feel close to my baby!\"", "authors": [{"family": "Khuzaiyah", "given": "Siti", "initials": "S"}, {"family": "Adnani", "given": "Qorinah Estiningtyas Sakilah", "initials": "QES"}, {"family": "Chabibah", "given": "Nur", "initials": "N"}, {"family": "Khanifah", "given": "Milatun", "initials": "M"}, {"family": "Lee", "given": "Ka Yiu", "initials": "KY"}], "type": "journal article", "published": "2022-07-04", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "volume": "21", "issue": "1", "pages": "175", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic impacts maternal and perinatal health. Fear of COVID-19 transmission may lead to psychological disorders among mothers, such as anxiety and depression, which might affect the infant's health. Innovation is needed to address problems related to this condition. This study aimed to explore the experiences of mothers who had attended online infant massage classes. METHODS: This qualitative survey recruited 12 Indonesian mothers who had infants aged < 12 months and joined the online infant massage class. An open-ended question form was used to collect data, which were analyzed using thematic content analysis.\n\nThere were six themes related to the experiences of mothers attending online infant massage classes: favorite session, new knowledge and skills, benefits, barriers during infant massage class, factors related to infant massage practice, and mother's hope.\n\nMothers had a good experience learning infant massage and had better interaction with their infants after the class. The findings show that an online infant massage class could benefit both mothers and infants.", "doi": "10.1186/s12912-022-00952-9", "pmid": "35787698", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12912-022-00952-9"}, {"db": "pmc", "key": "PMC9251925"}], "notes": [], "created": "2022-08-17T13:10:25.816Z", "modified": "2022-08-17T13:11:04.406Z"}, {"entity": "publication", "iuid": "689945ec3e6e417d9ef5a3de0de8f486", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/689945ec3e6e417d9ef5a3de0de8f486.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/689945ec3e6e417d9ef5a3de0de8f486"}}, "title": "The Effect of the COVID-19 Pandemic in Intestinal Rehabilitation and Transplant Patients: Initial Results of the Intestinal Rehabilitation and Transplant Association's International Survey.", "authors": [{"family": "Segovia", "given": "Maria", "initials": "M"}, {"family": "Fernandez", "given": "Maria Florencia", "initials": "MF"}, {"family": "Rumbo", "given": "Carolina", "initials": "C"}, {"family": "Zanfi", "given": "Chiara", "initials": "C"}, {"family": "Herlenius", "given": "Gustaf", "initials": "G"}, {"family": "Testro", "given": "Adam", "initials": "A"}, {"family": "Sharkey", "given": "Lisa", "initials": "L"}, {"family": "Braun", "given": "Felix", "initials": "F"}, {"family": "Jafri", "given": "Syed-Mohammed", "initials": "SM"}, {"family": "Vilca Melendez", "given": "Hector", "initials": "H"}, {"family": "Sanchez Claria", "given": "Rodrigo", "initials": "R"}, {"family": "Ceulemans", "given": "Laurens J", "initials": "LJ"}, {"family": "Hibi", "given": "Taizo", "initials": "T"}, {"family": "Solar", "given": "Hector", "initials": "H"}, {"family": "Ramisch", "given": "Diego", "initials": "D"}, {"family": "Noel", "given": "Gillian", "initials": "G"}, {"family": "Yap", "given": "Jason", "initials": "J"}, {"family": "Dijkstra", "given": "Gerard", "initials": "G"}, {"family": "Schiano", "given": "Thomas", "initials": "T"}, {"family": "Friend", "given": "Peter", "initials": "P"}, {"family": "Lacaille", "given": "Florence", "initials": "F"}, {"family": "Sudan", "given": "Debra", "initials": "D"}, {"family": "Mazariegos", "given": "George", "initials": "G"}, {"family": "Horslen", "given": "Simon", "initials": "S"}, {"family": "Gondolesi", "given": "Gabriel E", "initials": "GE"}], "type": "journal article", "published": "2022-07-01", "journal": {"title": "Transplantation", "issn": "1534-6080", "volume": "106", "issue": "7", "pages": "1289-1292", "issn-l": null}, "abstract": null, "doi": "10.1097/TP.0000000000004112", "pmid": "35731148", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00007890-202207000-00001"}, {"db": "pmc", "key": "PMC9213053"}], "notes": [], "created": "2022-08-17T13:06:38.928Z", "modified": "2022-08-17T13:06:38.942Z"}, {"entity": "publication", "iuid": "0eaabc4df5484e08b432df99ba66bab0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0eaabc4df5484e08b432df99ba66bab0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0eaabc4df5484e08b432df99ba66bab0"}}, "title": "Postacute elevation of D-dimer levels in severe acute respiratory syndrome coronavirus 2-positive nonhospitalized patients with mild symptoms.", "authors": [{"family": "Folkman", "given": "Rebecca", "initials": "R"}, {"family": "Kamal", "given": "Habiba", "initials": "H"}, {"family": "Ahl", "given": "Marcus", "initials": "M"}, {"family": "Szum", "given": "Adrian", "initials": "A"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Aleman", "given": "Soo", "initials": "S"}], "type": "journal article", "published": "2022-07-01", "journal": {"title": "Blood Coagul Fibrinolysis", "issn": "1473-5733", "volume": "33", "issue": "5", "pages": "285-287", "issn-l": null}, "abstract": null, "doi": "10.1097/MBC.0000000000001111", "pmid": "35703244", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00001721-990000000-00001"}], "notes": [], "created": "2022-08-17T12:59:42.144Z", "modified": "2022-08-17T13:00:05.206Z"}, {"entity": "publication", "iuid": "8f5a89f6b1bb484b8c9ddef1e8e7ec67", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f5a89f6b1bb484b8c9ddef1e8e7ec67.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f5a89f6b1bb484b8c9ddef1e8e7ec67"}}, "title": "Multidomain interventions for risk reduction and prevention of cognitive decline and dementia: current developments.", "authors": [{"family": "R\u00f6hr", "given": "Susanne", "initials": "S"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Mangialasche", "given": "Francesca", "initials": "F"}, {"family": "Ngandu", "given": "Tiia", "initials": "T"}, {"family": "Riedel-Heller", "given": "Steffi G", "initials": "SG"}], "type": "journal article", "published": "2022-07-01", "journal": {"title": "Curr Opin Psychiatry", "issn": "1473-6578", "volume": "35", "issue": "4", "pages": "285-292", "issn-l": null}, "abstract": "The potential for dementia prevention is deemed substantial if modifiable risk factors were addressed. First large-scale multidomain lifestyle interventions aiming at reducing risk of cognitive decline and dementia have yielded mixed but promising evidence.\n\nDespite the impact of the COVID-19 pandemic on trials conduction, causing interruptions and delays, the research landscape on multidomain interventions is growing rapidly. The successful Finish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) has led to an adaptation of the FINGER model in trials underway or being planned in over 40 countries. Recent studies identified barriers and facilitators of and adherence to multidomain interventions, showed the suitability of dementia risk scores as surrogate outcomes, and suggested mechanisms. Multidomain interventions are increasingly conducted in the Global South, and study protocols are increasingly testing expanded FINGER models, for example, with pharmacological components, in digital/remote settings and co-designed personalized interventions.\n\nThough results remain mixed, the many ongoing trials will provide more conclusive evidence within the next few years and help to optimize interventions. Continued international collaboration is pivotal to scale and accelerate the development and implementation of effective multidomain interventions as part of larger public health strategies to counteract the global dementia increase.", "doi": "10.1097/YCO.0000000000000792", "pmid": "35703256", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "00001504-990000000-00006"}], "notes": [], "created": "2022-06-20T18:11:52.181Z", "modified": "2022-08-17T12:58:51.225Z"}, {"entity": "publication", "iuid": "bc0b2685b3d34c29bfaf77ecbad868dc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bc0b2685b3d34c29bfaf77ecbad868dc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bc0b2685b3d34c29bfaf77ecbad868dc"}}, "title": "Management of Long COVID-The CoviMouv' Pilot Study: Importance of Adapted Physical Activity for Prolonged Symptoms Following SARS-CoV2 Infection.", "authors": [{"family": "Colas", "given": "Claire", "initials": "C"}, {"family": "Bayle", "given": "Manon", "initials": "M"}, {"family": "Labeix", "given": "Pierre", "initials": "P"}, {"family": "Botelho-Nevers", "given": "Elisabeth", "initials": "E"}, {"family": "Gagneux-Brunon", "given": "Amandine", "initials": "A"}, {"family": "Cazorla", "given": "C\u00e9line", "initials": "C"}, {"family": "Schein", "given": "Flora", "initials": "F"}, {"family": "Breugnon", "given": "Emma", "initials": "E"}, {"family": "Garcin", "given": "Arnauld", "initials": "A"}, {"family": "Feasson", "given": "L\u00e9onard", "initials": "L"}, {"family": "Roche", "given": "Fr\u00e9d\u00e9ric", "initials": "F"}, {"family": "Hupin", "given": "David", "initials": "D"}], "type": "journal article", "published": "2022-07-01", "journal": {"title": "Front Sports Act Living", "issn": "2624-9367", "volume": "4", "pages": "877188", "issn-l": null}, "abstract": "After a COVID-19 infection, some patients have persistent symptoms, the most common is fatigue. To prevent it from becoming chronic (post-COVID-19 syndrome), early management before 3 months could be useful. Exercise and education are recommended.\n\nTo assess fatigue in patients with prolonged symptoms after COVID-19 infection and who received a mixed program of remote adapted physical activity and therapeutic education. The secondary objective was to evaluate the efficacy and safety of this training method thanks to aerobic and anaerobic parameters.\n\n\"CoviMouv': From Coaching in Visual to Mouv in real\" is a nonrandomized controlled pilot study. Patients in telerehabilitation followed 12 remote exercise sessions and 3 therapeutic education workshops. Patients on traditional rehabilitation followed their program with a community-based physiotherapist.\n\nFatigue was reduced after the one-month intervention in both groups (p = 0.010). The majority of aerobic parameters were significantly improved, e.g., maximal oxygen uptake (p = 0.005), walking distance (p = 0.019) or hyperventilation values (p = 0.035). The anaerobic parameter was not improved (p = 0.400). No adverse event was declared.\n\nTelerehabilitation is a good alternative when a face-to-face program is not possible. This care at an early stage of the disease could help prevent the chronicity of post-COVID-19 symptoms and the installation of vicious circles of physical deconditioning. A larger study would be necessary.", "doi": "10.3389/fspor.2022.877188", "pmid": "35847457", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9283867"}], "notes": [], "created": "2022-08-12T08:52:50.981Z", "modified": "2022-08-12T08:52:50.987Z"}, {"entity": "publication", "iuid": "e82f7989e13243b19c9ab5812b957407", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e82f7989e13243b19c9ab5812b957407.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e82f7989e13243b19c9ab5812b957407"}}, "title": "Decision support-tools for early detection of infection in older people (aged> 65 years): a scoping review.", "authors": [{"family": "Masot", "given": "Olga", "initials": "O"}, {"family": "Cox", "given": "Anna", "initials": "A"}, {"family": "Mold", "given": "Freda", "initials": "F"}, {"family": "Sund-Levander", "given": "M\u00e4rtha", "initials": "M"}, {"family": "Tingstr\u00f6m", "given": "Pia", "initials": "P"}, {"family": "Boersema", "given": "Geertien Christelle", "initials": "GC"}, {"family": "Botigu\u00e9", "given": "Teresa", "initials": "T"}, {"family": "Daltrey", "given": "Julie", "initials": "J"}, {"family": "Hughes", "given": "Karen", "initials": "K"}, {"family": "Mayhorn", "given": "Christopher B", "initials": "CB"}, {"family": "Montgomery", "given": "Amy", "initials": "A"}, {"family": "Mullan", "given": "Judy", "initials": "J"}, {"family": "Carey", "given": "Nicola", "initials": "N"}], "type": "journal article", "published": "2022-07-01", "journal": {"title": "BMC Geriatr", "issn": "1471-2318", "volume": "22", "issue": "1", "pages": "552", "issn-l": null}, "abstract": "Infection is more frequent, and serious in people aged > 65 as they experience non-specific signs and symptoms delaying diagnosis and prompt treatment. Monitoring signs and symptoms using decision support tools (DST) is one approach that could help improve early detection ensuring timely treatment and effective care.\n\nTo identify and analyse decision support tools available to support detection of infection in older people (> 65 years).\n\nA scoping review of the literature 2010-2021 following Arksey and O'Malley (2005) framework and PRISMA-ScR guidelines. A search of MEDLINE, Cochrane, EMBASE, PubMed, CINAHL, Scopus and PsycINFO using terms to identify decision support tools for detection of infection in people > 65 years was conducted, supplemented with manual searches.\n\nSeventeen papers, reporting varying stages of development of different DSTs were analysed. DSTs largely focussed on specific types of infection i.e. urine, respiratory, sepsis and were frequently hospital based (n = 9) for use by physicians. Four DSTs had been developed in nursing homes and one a care home, two of which explored detection of non- specific infection.\n\nDSTs provide an opportunity to ensure a consistent approach to early detection of infection supporting prompt action and treatment, thus avoiding emergency hospital admissions. A lack of consideration regarding their implementation in practice means that any attempt to create an optimal validated and tested DST for infection detection will be impeded. This absence may ultimately affect the ability of the workforce to provide more effective and timely care, particularly during the current covid-19 pandemic.", "doi": "10.1186/s12877-022-03218-w", "pmid": "35778707", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12877-022-03218-w"}, {"db": "pmc", "key": "PMC9247966"}], "notes": [], "created": "2022-08-17T13:12:07.701Z", "modified": "2022-08-17T13:12:07.714Z"}, {"entity": "publication", "iuid": "17f887a93df245fbb3c3380cb298d54e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/17f887a93df245fbb3c3380cb298d54e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/17f887a93df245fbb3c3380cb298d54e"}}, "title": "Chemistry of Protein-Phenolic Interactions Toward the Microbiota and Microbial Infections.", "authors": [{"family": "Yilmaz", "given": "Hilal", "initials": "H"}, {"family": "Gultekin Subasi", "given": "Busra", "initials": "B"}, {"family": "Celebioglu", "given": "Hasan Ufuk", "initials": "HU"}, {"family": "Ozdal", "given": "Tugba", "initials": "T"}, {"family": "Capanoglu", "given": "Esra", "initials": "E"}], "type": "journal article", "published": "2022-07-01", "journal": {"title": "Front Nutr", "issn": "2296-861X", "volume": "9", "pages": "914118", "issn-l": null}, "abstract": "Along with health concerns, interest in plants as food and bioactive phytochemical sources has been increased in the last few decades. Phytochemicals as secondary plant metabolites have been the subject of many studies in different fields. Breakthrough for research interest on this topic is re-juvenilized with rising relevance in this global pandemics' era. The recent COVID-19 pandemic attracted the attention of people to viral infections and molecular mechanisms behind these infections. Thus, the core of the present review is the interaction of plant phytochemicals with proteins as these interactions can affect the functions of co-existing proteins, especially focusing on microbial proteins. To the best of our knowledge, there is no work covering the protein-phenolic interactions based on their effects on microbiota and microbial infections. The present review collects and defines the recent data, representing the interactions of phenolic compounds -primarily flavonoids and phenolic acids- with various proteins and explores how these molecular-level interactions account for the human health directly and/or indirectly, such as increased antioxidant properties and antimicrobial capabilities. Furthermore, it provides an insight about the further biological activities of interacted protein-phenolic structure from an antiviral activity perspective. The research on the protein-phenolic interaction mechanisms is of great value for guiding how to take advantage of synergistic effects of proteins and polyphenolics for future medical and nutritive approaches and related technologies.", "doi": "10.3389/fnut.2022.914118", "pmid": "35845785", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC9284217"}], "notes": [], "created": "2022-08-12T08:53:09.405Z", "modified": "2022-08-12T08:53:27.220Z"}, {"entity": "publication", "iuid": "87681bb5e6364fdc9e6084741f69928e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87681bb5e6364fdc9e6084741f69928e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87681bb5e6364fdc9e6084741f69928e"}}, "title": "A rapid assessment of take-home naloxone provision during COVID-19 in Europe.", "authors": [{"family": "McDonald", "given": "Rebecca", "initials": "R"}, {"family": "Eide", "given": "Desiree", "initials": "D"}, {"family": "Abel-Ollo", "given": "Katri", "initials": "K"}, {"family": "Barnsdale", "given": "Lee", "initials": "L"}, {"family": "Carter", "given": "Ben", "initials": "B"}, {"family": "Clausen", "given": "Thomas", "initials": "T"}, {"family": "Day", "given": "Ed", "initials": "E"}, {"family": "Fonseca", "given": "Francina", "initials": "F"}, {"family": "Holm\u00e9n", "given": "Elin", "initials": "E"}, {"family": "Horsburgh", "given": "Kirsten", "initials": "K"}, {"family": "Kelleher", "given": "Mike", "initials": "M"}, {"family": "K\u00e5berg", "given": "Martin", "initials": "M"}, {"family": "Ladenhauf", "given": "Martin", "initials": "M"}, {"family": "McAuley", "given": "Andrew", "initials": "A"}, {"family": "Metrebian", "given": "Nicola", "initials": "N"}, {"family": "Neale", "given": "Joanne", "initials": "J"}, {"family": "Parkin", "given": "Stephen", "initials": "S"}, {"family": "Ratcliffe", "given": "Kevin", "initials": "K"}, {"family": "Rintoul", "given": "Chris", "initials": "C"}, {"family": "Smith", "given": "Josie", "initials": "J"}, {"family": "Stifanoviciute", "given": "Viktorija", "initials": "V"}, {"family": "Torrens", "given": "Marta", "initials": "M"}, {"family": "Thiesen", "given": "Henrik", "initials": "H"}, {"family": "Strang", "given": "John", "initials": "J"}], "type": "journal article", "published": "2022-07-01", "journal": {"title": "Int J Drug Policy", "issn": "1873-4758", "volume": "107", "pages": "103787", "issn-l": null}, "abstract": "In March 2020, the World Health Organization declared COVID-19 a global pandemic. In the following weeks, most European countries implemented national lockdowns to mitigate viral spread. Services for people who use drugs had to quickly revise their operating procedures to rearrange service provision while adhering to lockdown requirements. Given the scarcity of literature published on overdose prevention during COVID-19 in Europe, we aimed to examine how these changes to service provision affected take-home naloxone (THN) programmes and naloxone availability across Europe.\n\nBetween November 2020 and January 2021, we conducted a rapid assessment with country experts from European countries that provide THN. We sent country experts a template to report monthly THN distribution data (January 1, 2019-October 31, 2020) and a structured 6-item survey for completion.\n\nResponses were received from 14 of the 15 European countries with THN provision of which 11 participated in the rapid assessment: Austria, Denmark, England, Estonia, Lithuania, Northern Ireland, Norway, Scotland, Spain (Catalonia only), Sweden, and Wales. All reported reduced organisational capacity during COVID-19, and some put into place a range of novel approaches to manage the restrictions on face-to-face service provision. In six countries, the introduction of programme innovation occurred alongside the publication of government guidelines recommending increased THN provision during COVID-19. Eight of the eleven participating countries managed to maintain 2019-level monthly THN distribution rates or even increase provision during the pandemic.\n\nThrough programme innovation supported by public guidelines, many European THN programmes managed to ensure stable or even increased THN provision during the pandemic, despite social distancing and stay-at-home orders affecting client mobility.", "doi": "10.1016/j.drugpo.2022.103787", "pmid": "35849935", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0955-3959(22)00202-X"}, {"db": "pmc", "key": "PMC9247228"}], "notes": [], "created": "2022-08-12T08:52:12.188Z", "modified": "2022-08-12T08:52:12.218Z"}, {"entity": "publication", "iuid": "d56ed86be45b4b0693bf640956ac99e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d56ed86be45b4b0693bf640956ac99e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d56ed86be45b4b0693bf640956ac99e1"}}, "title": "Treatment seeking for alcohol-related issues during the COVID-19 pandemic: An analysis of an addiction-specialized psychiatric treatment facility.", "authors": [{"family": "Andersson", "given": "Mitchell J", "initials": "MJ"}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": "8", "issue": "7", "pages": "e09934", "issn-l": null}, "abstract": "The COVID-19 pandemic and its societal impact may cause long-term behavioral changes in alcohol use due to increased psychological distress, unemployment, and time spent home. The purpose of this study was to determine whether or not the COVID-19 pandemic had a significant impact on treatment seeking for alcohol use disorders and related problems in a Swedish psychiatric treatment facility. Using an interrupted-time-series design on data derived from an addiction-specific psychiatric treatment facility located in Malm\u00f6, Sweden, we hypothesized that treatment seeking would decrease during the pandemic based on previous research identifying limited alcohol availability and affordability, as well as accessibility to treatment centers as influential factors. In addition, we assessed the predictive power of alcohol sales and number of active cases in the region using simple linear regressions. Results indicated that the pandemic had little to no effect on the number of people needing care, however a significant step change was found in treatment seeking patterns for unique female patients during the second wave (October 2020). Regression analyses indicated that alcohol sales and the number of active cases in the region did not significantly predict treatment seeking. A causal relationship between the onset of the pandemic and variation in treatment seeking for alcohol use could not be established. More research is needed to fully understand the pandemic's impact on alcohol use behavior change.", "doi": "10.1016/j.heliyon.2022.e09934", "pmid": "35855398", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(22)01222-1"}, {"db": "pmc", "key": "PMC9279183"}], "notes": [], "created": "2022-08-12T08:48:53.757Z", "modified": "2022-08-12T08:48:53.762Z"}, {"entity": "publication", "iuid": "2d232ef960984198bc09259d47b6c316", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d232ef960984198bc09259d47b6c316.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d232ef960984198bc09259d47b6c316"}}, "title": "Repurposing of antiviral drugs for COVID-19 and impact of repurposed drugs on the nervous system.", "authors": [{"family": "Punekar", "given": "Madhura", "initials": "M"}, {"family": "Kshirsagar", "given": "Manas", "initials": "M"}, {"family": "Tellapragada", "given": "Chaitanya", "initials": "C"}, {"family": "Patil", "given": "Kanchankumar", "initials": "K"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Microb Pathog", "issn": "1096-1208", "volume": "168", "pages": "105608", "issn-l": null}, "abstract": "The recent pandemic, Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has devastated humanity and is continuing to threaten us. Due to the high transmissibility of this pathogen, researchers are still trying to cope with the treatment and prevention of this disease. Few of them were successful in finding cure for COVID-19 by including repurposed drugs in the treatment. In such pandemic situations, when it is nearly impossible to design and implement a new drug target, previously designed antiviral drugs could help against novel viruses, referred to as drug repurposing/redirecting/repositioning or re-profiling. This review describes the current landscape of the repurposing of antiviral drugs for COVID-19 and the impact of these drugs on our nervous system. In some cases, specific antiviral therapy has been notably associated with neurological toxicity, characterized by peripheral neuropathy, neurocognitive and neuropsychiatric effects within the central nervous system (CNS).", "doi": "10.1016/j.micpath.2022.105608", "pmid": "35654381", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0882-4010(22)00221-2"}], "notes": [], "created": "2022-06-21T17:21:10.384Z", "modified": "2022-06-21T17:21:10.420Z"}, {"entity": "publication", "iuid": "f59339d3ad1844a095d84107b01f0f97", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f59339d3ad1844a095d84107b01f0f97.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f59339d3ad1844a095d84107b01f0f97"}}, "title": "Predicting attitudinal and behavioral responses to COVID-19 pandemic using machine learning.", "authors": [{"family": "Pavlovi\u0107", "given": "Tomislav", "initials": "T", "orcid": "0000-0002-4470-3715", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b5a5d7b53914f58ba60821e70539887.json"}}, {"family": "Azevedo", "given": "Flavio", "initials": "F", "orcid": "0000-0001-9000-8513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7864cb0e9bf846d6b69a6a5bf65cbd91.json"}}, {"family": "De", "given": "Koustav", "initials": "K", "orcid": "0000-0001-9562-0672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d6627eccf1d42baa44ed1ab89430f41.json"}}, {"family": "Ria\u00f1o-Moreno", "given": "Juli\u00e1n C", "initials": "JC", "orcid": "0000-0003-4182-0550", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/152a5f53020c49b8bac49dd90ac28253.json"}}, {"family": "Magli\u0107", "given": "Marina", "initials": "M", "orcid": "0000-0002-6851-4601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d8c351f3a484c3690ba0fa55f7cebdb.json"}}, {"family": "Gkinopoulos", "given": "Theofilos", "initials": "T", "orcid": "0000-0003-1070-6245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79f358d2d829449abfbcaee30042cc75.json"}}, {"family": "Donnelly-Kehoe", "given": "Patricio Andreas", "initials": "PA", "orcid": "0000-0002-3738-9537", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1477fc6c8a649d39e2f3f99d2580e95.json"}}, {"family": "Pay\u00e1n-G\u00f3mez", "given": "C\u00e9sar", "initials": "C", "orcid": "0000-0002-0633-1332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f473ea4639241fda23bf7f76ac9fef9.json"}}, {"family": "Huang", "given": "Guanxiong", "initials": "G", "orcid": "0000-0002-8588-1454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a1c0bc719e64cfb968124490fe30f56.json"}}, {"family": "Kantorowicz", "given": "Jaroslaw", "initials": "J", "orcid": "0000-0002-1186-5427", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/848df4a38f424410994e5c106185d6be.json"}}, {"family": "Birtel", "given": "Mich\u00e8le D", "initials": "MD", "orcid": "0000-0002-2383-9197", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d0e795d0cd4435586f09edfabffa510.json"}}, {"family": "Sch\u00f6negger", "given": "Philipp", "initials": "P", "orcid": "0000-0001-9930-487X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35568fb99a374c0a991a4be87eefa994.json"}}, {"family": "Capraro", "given": "Valerio", "initials": "V", "orcid": "0000-0002-0579-0166", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2eb7cac8bce492b93cf98134a322d4c.json"}}, {"family": "Santamar\u00eda-Garc\u00eda", "given": "Hernando", "initials": "H", "orcid": "0000-0001-9422-3579", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40b9f8cec76a4451862823b554f351c6.json"}}, {"family": "Yucel", "given": "Meltem", "initials": "M", "orcid": "0000-0002-7274-5971", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65a44c75ffa1499abea1909977b44e79.json"}}, {"family": "Ibanez", "given": "Agustin", "initials": "A", "orcid": "0000-0001-6758-5101", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4ec1841513243d981ba5cba471bc1d9.json"}}, {"family": "Rathje", "given": "Steve", "initials": "S", "orcid": "0000-0001-6727-571X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/358b4bc86edc4ff395946f7d420d28b8.json"}}, {"family": "Wetter", "given": "Erik", "initials": "E", "orcid": "0000-0002-5821-6651", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2fa438fa71224f4cb513cee60e632925.json"}}, {"family": "Stanojevi\u0107", "given": "Dragan", "initials": "D", "orcid": "0000-0002-3667-2461", "researcher": {"href": 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"initials": "Z", "orcid": "0000-0002-9231-5100", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/976f634ec7ff487a9e886500ff7f52ca.json"}}, {"family": "Mitkidis", "given": "Panagiotis", "initials": "P", "orcid": "0000-0002-9495-7369", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40b0c9405e1d4aef8a53e669fdb8847d.json"}}, {"family": "Cichocka", "given": "Aleksandra", "initials": "A", "orcid": "0000-0003-1703-1586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0cc1202c8fb34d07952c7d99ab43bf87.json"}}, {"family": "Gelfand", "given": "Michele", "initials": "M"}, {"family": "Alfano", "given": "Mark", "initials": "M", "orcid": "0000-0001-5879-8033", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9adf19b051647d19c86bc89ee440988.json"}}, {"family": "Ross", "given": "Robert M", "initials": "RM", "orcid": "0000-0001-8711-1675", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49cb2e4d713844729ee7d64213f3cdbe.json"}}, {"family": "Sj\u00e5stad", "given": "Hallgeir", "initials": "H", "orcid": "0000-0002-8730-1038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9d4b3d4379f4e3bb43607c0ef08f159.json"}}, {"family": "Nezlek", "given": "John B", "initials": "JB", "orcid": "0000-0003-4963-3637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab0b925a3d5b4c3d9f03d141757d41ba.json"}}, {"family": "Cislak", "given": "Aleksandra", "initials": "A", "orcid": "0000-0002-9880-6947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37e0b6640a76467890fed6a7975b031c.json"}}, {"family": "Lockwood", "given": "Patricia", "initials": "P", "orcid": "0000-0001-7195-9559", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d77d4779b0ff456b906f2001dc3aa36f.json"}}, {"family": "Abts", "given": "Koen", "initials": "K", "orcid": "0000-0001-8546-8347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9128fa7c6104fecabd5e4e52b1ce6ee.json"}}, {"family": "Agadullina", "given": "Elena", "initials": "E", "orcid": "0000-0002-1505-1412", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1d55ff13a5b4373abb3aca1376a41b9.json"}}, {"family": "Amodio", "given": "David M", "initials": "DM", "orcid": "0000-0001-7746-0150", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/909d9da1100b49cfb829c88277849da2.json"}}, {"family": "Apps", "given": "Matthew A J", "initials": "MAJ", "orcid": "0000-0001-5793-2202", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd23864c1da2420aab5bc56d02b7f770.json"}}, {"family": "Aruta", "given": "John Jamir Benzon", "initials": "JJB", "orcid": "0000-0003-4155-1063", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc1b14a0e89b4d9cb7f9c977e34a9a67.json"}}, {"family": "Besharati", "given": "Sahba", "initials": "S", "orcid": "0000-0003-2836-7982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8948fcda91f444f89cc8ddcfe4e489d9.json"}}, {"family": "Bor", "given": "Alexander", "initials": "A", "orcid": "0000-0002-2624-9221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/048bdb252beb4b2599b619f41ace6277.json"}}, {"family": "Choma", "given": "Becky", "initials": "B", "orcid": "0000-0002-8286-8983", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/207911cc2901427598e7b5f60bd927da.json"}}, {"family": "Cunningham", "given": "William", "initials": "W"}, {"family": "Ejaz", "given": "Waqas", "initials": "W", "orcid": "0000-0002-2492-4115", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0540fea51e3740068aa543e3e9bfd57e.json"}}, 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"orcid": "0000-0002-0794-7702", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8177b1e630c54506b665af61a4204f3c.json"}}, {"family": "Zwaan", "given": "Rolf A", "initials": "RA", "orcid": "0000-0001-9967-7879", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c6e9acd4b0c4c3881f364b11f0dc8d0.json"}}, {"family": "Boggio", "given": "Paulo Sergio", "initials": "PS", "orcid": "0000-0002-6109-0447", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1a661afdf824fa596f035139880c521.json"}}, {"family": "Whillans", "given": "Ashley", "initials": "A"}, {"family": "Van Lange", "given": "Paul A M", "initials": "PAM", "orcid": "0000-0001-7774-6984", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14e8d477999b4beb9878beb5f7ee3e99.json"}}, {"family": "Prasad", "given": "Rajib", "initials": "R", "orcid": "0000-0003-0913-1624", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22102152292941f183ae692ea2e24a2a.json"}}, {"family": "Onderco", "given": "Michal", "initials": "M", "orcid": "0000-0001-9911-3782", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeef609fb2c44af5b8f38042a590b931.json"}}, {"family": "O'Madagain", "given": "Cathal", "initials": "C", "orcid": "0000-0002-4086-524X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee7ab547d0f146929e7aece70f30cd24.json"}}, {"family": "Nesh-Nash", "given": "Tarik", "initials": "T", "orcid": "0000-0002-5532-9095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b8406427e494a16b95e8e3aebf40345.json"}}, {"family": "Laguna", "given": "Oscar Moreda", "initials": "OM"}, {"family": "Kubin", "given": "Emily", "initials": "E", "orcid": "0000-0003-0606-8594", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bf123de600e4b958365eb744b78825a.json"}}, {"family": "G\u00fcmren", "given": "Mert", "initials": "M", "orcid": "0000-0002-3298-6295", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46f817818fab49a18e8576bbe9775d11.json"}}, {"family": "Fenwick", "given": "Ali", "initials": "A", "orcid": "0000-0002-5412-9745", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f45980f8496c4d039e2bdbb71bdf7a8c.json"}}, {"family": "Ertan", "given": "Arhan S", "initials": "AS", "orcid": "0000-0001-9730-8391", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/459a43a3f47548c3a73d95dbba35127e.json"}}, {"family": "Bernstein", "given": "Michael J", "initials": "MJ", "orcid": "0000-0002-8083-9839", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12779a2d6b544bf994b765780cde0723.json"}}, {"family": "Amara", "given": "Hanane", "initials": "H", "orcid": "0000-0003-0732-2320", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88b038a62a4845d6a7f46f40071a8d42.json"}}, {"family": "Van Bavel", "given": "Jay Joseph", "initials": "JJ", "orcid": "0000-0002-2520-0442", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/344fbd5da7bc4259b3f70839f401c84c.json"}}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "PNAS Nexus", "issn": "2752-6542", "volume": "1", "issue": "3", "pages": "pgac093", "issn-l": null}, "abstract": "At the beginning of 2020, COVID-19 became a global problem. Despite all the efforts to emphasize the relevance of preventive measures, not everyone adhered to them. Thus, learning more about the characteristics determining attitudinal and behavioral responses to the pandemic is crucial to improving future interventions. In this study, we applied machine learning on the multinational data collected by the International Collaboration on the Social and Moral Psychology of COVID-19 (N = 51,404) to test the predictive efficacy of constructs from social, moral, cognitive, and personality psychology, as well as socio-demographic factors, in the attitudinal and behavioral responses to the pandemic. The results point to several valuable insights. Internalized moral identity provided the most consistent predictive contribution-individuals perceiving moral traits as central to their self-concept reported higher adherence to preventive measures. Similar results were found for morality as cooperation, symbolized moral identity, self-control, open-mindedness, and collective narcissism, while the inverse relationship was evident for the endorsement of conspiracy theories. However, we also found a non-neglible variability in the explained variance and predictive contributions with respect to macro-level factors such as the pandemic stage or cultural region. Overall, the results underscore the importance of morality-related and contextual factors in understanding adherence to public health recommendations during the pandemic.", "doi": "10.1093/pnasnexus/pgac093", "pmid": "35990802", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "pgac093"}, {"db": "pmc", "key": "PMC9381137"}], "notes": [], "created": "2022-09-12T18:51:19.761Z", "modified": "2022-09-12T18:51:22.853Z"}, {"entity": "publication", "iuid": "fa42143e23004ff695be370f9d78be58", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa42143e23004ff695be370f9d78be58.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa42143e23004ff695be370f9d78be58"}}, "title": "Living with the aftermaths of a stroke in the era of the COVID-19 pandemic; the significance of home and close surroundings.", "authors": [{"family": "Kyl\u00e9n", "given": "Maya", "initials": "M"}, {"family": "von Koch", "given": "Lena", "initials": "L"}, {"family": "Wottrich", "given": "Annica Wohlin", "initials": "AW"}, {"family": "Elf", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Health Place", "issn": "1873-2054", "volume": "76", "pages": "102852", "issn-l": null}, "abstract": "Stay-at-home recommendations to reduce the spread of the COVID-19 virus have had a major impact on people's everyday lives. However, while the evidence indicates that such recommendations have caused distress, anxiety, and fear among the public, little is known about how persons living with complex health conditions, e.g., disability after stroke, have experienced and handled the situation. We interviewed fourteen participants (7 women, 7 men) aged 61-91 years living in ordinary housing during summer 2020 to explore how people who recovered after a stroke experienced their everyday lives in their homes and close surroundings during the COVID-19 pandemic recommendations. Three intertwined themes were constructed from the narrative data and the iterative thematic analysis: (1) Places within and out of reach, (2) Upholding activities-strategies and structures, and (3) Adapting to new circumstances. The findings suggest that places within reach were important to maintain activities and provide structure in daily life. The participants seemed to make use of their previous experiences of adjusting to new circumstances after stroke when adapting to living under the stay-at-home recommendations. In addition, feeling that they now shared the restrictions with all other people in society seemed to ease their situations. Access to nature and spaces in the close surroundings was essential for staying socially connected and receiving support in daily life. The significance of the home and the neighbourhood for health experiences among people who recently have had a stroke should inform rehabilitation interventions both during and after pandemics and environmental planning.", "doi": "10.1016/j.healthplace.2022.102852", "pmid": "35803042", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1353-8292(22)00113-7"}, {"db": "pmc", "key": "PMC9222220"}], "notes": [], "created": "2022-08-17T10:44:25.664Z", "modified": "2022-08-17T10:44:36.090Z"}, {"entity": "publication", "iuid": "44c5299a78d54745b8e0de0df6e5aaa9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44c5299a78d54745b8e0de0df6e5aaa9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44c5299a78d54745b8e0de0df6e5aaa9"}}, "title": "Impacts of severity of Covid-19 infection on the morbidity and mortality of surgical patients.", "authors": [{"family": "Al Ani", "given": "Amer", "initials": "A"}, {"family": "Tahtamoni", "given": "Rafeef", "initials": "R"}, {"family": "Mohammad", "given": "Yara", "initials": "Y"}, {"family": "Al-Ayoubi", "given": "Fawzi", "initials": "F"}, {"family": "Haider", "given": "Nadeem", "initials": "N"}, {"family": "Al-Mashhadi", "given": "Ammar", "initials": "A"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Ann Med Surg (Lond)", "issn": "2049-0801", "pages": "103910", "volume": "79", "issn-l": null}, "abstract": "One of the challenges of surgery on patients with active SARS-CoV-2(severe acute respiratory syndrome coronavirus 2) infection is the increased risk of postoperative morbidity and mortality.\n\nThis study will describe and compare the postoperative morbidity and mortality in asymptomatic patients or those with mild infection with those with severe COVID-19 infection undergoing elective or and emergency surgery.\n\nThis is a retrospective study of 37 COVID19 patients who had the infection 7 days prior to and 30 days after emergency or elective surgery. Patients were divided to two groups. Group1: the asymptomatic or those with mild infection that is diagnosed just before surgery (14 patients). Group 2: those who were admitted to the hospital because of severe COVID-19 and were operated for COVID-19 related complications (23 patients). Morbidity and mortality of both groups was studied.\n\nThere was no significant difference in gender between the two groups. There were 5 females (2 in group 1, and 3 in group 2) and 32 males (12 in group 1, and 20 in group 2). Mean age for all patients was 49.8years (38 for group 1 and 57 for group2). Median age for all patients was 50 years (37.5 for group 1 and 57 years for group 2). Sepsis developed in 7 patients (1 patient in group 1 and in 6 patients in group 2). Statistically there was no significant difference in occurrence of sepsis between the two groups. There was a significant difference in the intensive care stay between the two groups (higher in group 2). Four deaths were reported in group 1 and fourteen in group 2. Eighteen out of thirty-seven patients died.\n\nSeverity of COVID-19 infection will prolong the hospitalization and ICU stay in surgical patients with no significant effect on mortality.", "doi": "10.1016/j.amsu.2022.103910", "pmid": "35698648", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2049-0801(22)00670-7"}, {"db": "pmc", "key": "PMC9176105"}], "notes": [], "created": "2022-06-20T18:16:44.976Z", "modified": "2022-08-17T13:02:53.070Z"}, {"entity": "publication", "iuid": "66a8f5b641e34e5e903816b561a944a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66a8f5b641e34e5e903816b561a944a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66a8f5b641e34e5e903816b561a944a1"}}, "title": "Immune responses after omicron infection in triple-vaccinated health-care workers with and without previous SARS-CoV-2 infection.", "authors": [{"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Norin", "given": "Nina Greilert", "initials": "NG"}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Garc\u00eda", "given": "Marina", "initials": "M"}, {"family": "Tecleab", "given": "Teghesti", "initials": "T"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Forsell", "given": "Mattias", "initials": "M"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "letter", "published": "2022-07-00", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "issn-l": null, "volume": "22", "issue": "7", "pages": "943-945"}, "abstract": null, "doi": "10.1016/S1473-3099(22)00362-0", "pmid": "35691303", "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9183210"}, {"db": "pii", "key": "S1473-3099(22)00362-0"}], "notes": [], "created": "2022-06-20T18:21:45.781Z", "modified": "2023-06-19T14:27:30.544Z"}, {"entity": "publication", "iuid": "4a9fbf6212c841cc8bc0ff99dfa7f18b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4a9fbf6212c841cc8bc0ff99dfa7f18b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4a9fbf6212c841cc8bc0ff99dfa7f18b"}}, "title": "Follow-up regimes for sick-listed employees: A comparison of nine north-western European countries.", "authors": [{"family": "Ose", "given": "Solveig Osborg", "initials": "SO"}, {"family": "Kaspersen", "given": "Silje Lill", "initials": "SL"}, {"family": "Leinonen", "given": "Taina", "initials": "T"}, {"family": "Verstappen", "given": "Suzanne", "initials": "S"}, {"family": "de Rijk", "given": "Angelique", "initials": "A"}, {"family": "Spasova", "given": "Slavina", "initials": "S"}, {"family": "Hultqvist", "given": "Sara", "initials": "S"}, {"family": "N\u00f8rup", "given": "Iben", "initials": "I"}, {"family": "P\u00e1lsson", "given": "J\u00f3n R", "initials": "JR"}, {"family": "Blume", "given": "Andreas", "initials": "A"}, {"family": "Paternoga", "given": "Mike", "initials": "M"}, {"family": "Kalseth", "given": "Jorid", "initials": "J"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Health Policy", "issn": "0168-8510", "volume": "126", "issue": "7", "pages": "619-631", "issn-l": null}, "abstract": "The Covid-19 pandemic has revealed the importance of social protection systems, including income security, when health problems arise. The aims of this study are to compare the follow-up regimes for sick-listed employees across nine European countries, and to conduct a qualitative assessment of the differences with respect to burden and responsibility sharing between the social protection system, employers and employees. The tendency highlighted is that countries with shorter employer periods of sick-pay typically have stricter follow-up responsibility for employers because, in practice, they become gatekeepers of the public sickness benefit scheme. In Germany and the UK, employers have few requirements for follow-up compared with the Nordic countries because they bear most of the costs of sickness absence themselves. The same applies in Iceland, where employers carry most of the costs and have no obligation to follow up sick-listed employees. The situation in the Netherlands is paradoxical: employers have strict obligations in the follow-up regime even though they cover all the costs of the sick-leave themselves. During the pandemic, the majority of countries have adjusted their sick-pay system and increased coverage to reduce the risk of spreading Covid-19 because employees are going to work sick or when they should self-quarantine, except for the Netherlands and Belgium, which considered that the current schemes were already sufficient to reduce that risk.", "doi": "10.1016/j.healthpol.2022.05.002", "pmid": "35577620", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0168-8510(22)00104-X"}, {"db": "pmc", "key": "PMC9085445"}], "notes": [], "created": "2022-06-21T18:05:44.262Z", "modified": "2022-06-21T18:05:45.486Z"}, {"entity": "publication", "iuid": "07ee362db00f4e4892091f0ed7f26e18", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07ee362db00f4e4892091f0ed7f26e18.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07ee362db00f4e4892091f0ed7f26e18"}}, "title": "Factors associated with clinical progression to severe COVID-19 in people with cystic fibrosis: A global observational study.", "authors": [{"family": "Carr", "given": "Siobh\u00e1n B", "initials": "SB"}, {"family": "McClenaghan", "given": "Elliot", "initials": "E"}, {"family": "Elbert", "given": "Alexander", "initials": "A"}, {"family": "Faro", "given": "Albert", "initials": "A"}, {"family": "Cosgriff", "given": "Rebecca", "initials": "R"}, {"family": "Abdrakhmanov", "given": "Olzhas", "initials": "O"}, {"family": "Brownlee", "given": "Keith", "initials": "K"}, {"family": "Burgel", "given": "Pierre-R\u00e9gis", "initials": "PR"}, {"family": "Byrnes", "given": "Catherine A", "initials": "CA"}, {"family": "Cheng", "given": "Stephanie Y", "initials": "SY"}, {"family": "Colombo", "given": "Carla", "initials": "C"}, {"family": "Corvol", "given": "Harriet", "initials": "H"}, {"family": "Daneau", "given": "G\u00e9raldine", "initials": "G"}, {"family": "Goss", "given": "Christopher H", "initials": "CH"}, {"family": "Gulmans", "given": "Vincent", "initials": "V"}, {"family": "Gutierrez", "given": "Hector", "initials": "H"}, {"family": "Harutyunyan", "given": "Satenik", "initials": "S"}, {"family": "Helmick", "given": "Meagan", "initials": "M"}, {"family": "Jung", "given": "Andreas", "initials": "A"}, {"family": "Kashirskaya", "given": "Nataliya", "initials": "N"}, {"family": "McKone", "given": "Edward", "initials": "E"}, {"family": "Melo", "given": "Joel", "initials": "J"}, {"family": "Middleton", "given": "Peter G", "initials": "PG"}, {"family": "Mondejar-Lopez", "given": "Pedro", "initials": "P"}, {"family": "de Monestrol", "given": "Isabelle", "initials": "I"}, {"family": "N\u00e4hrlich", "given": "Lutz", "initials": "L"}, {"family": "Padoan", "given": "Rita", "initials": "R"}, {"family": "Parker", "given": "Megan", "initials": "M"}, {"family": "Pastor-Vivero", "given": "M Dolores", "initials": "MD"}, {"family": "Rizvi", "given": "Samar", "initials": "S"}, {"family": "Ruseckaite", "given": "Rasa", "initials": "R"}, {"family": "Salvatore", "given": "Marco", "initials": "M"}, {"family": "da Silva-Filho", "given": "Luiz Vicente R F", "initials": "LVRF"}, {"family": "Versmessen", "given": "Nick", "initials": "N"}, {"family": "Zampoli", "given": "Marco", "initials": "M"}, {"family": "Marshall", "given": "Bruce C", "initials": "BC"}, {"family": "Stephenson", "given": "Anne L", "initials": "AL"}, {"family": "CF Registry Global Collaboration", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "J Cyst Fibros", "issn": "1873-5010", "volume": "21", "issue": "4", "pages": "e221-e231", "issn-l": null}, "abstract": "This international study aimed to characterise the impact of acute SARS-CoV-2 infection in people with cystic fibrosis and investigate factors associated with severe outcomes. Methods Data from 22 countries prior to 13th December 2020 and the introduction of vaccines were included. It was de-identified and included patient demographics, clinical characteristics, treatments, outcomes and sequalae following SARS-CoV-2 infection. Multivariable logistic regression was used to investigate factors associated with clinical progression to severe COVID-19, using the primary outcome of hospitalisation with supplemental oxygen.\n\nSARS-CoV-2 was reported in 1555 people with CF, 1452 were included in the analysis. One third were aged <18 years, and 9.4% were solid-organ transplant recipients. 74.5% were symptomatic and 22% were admitted to hospital. In the non-transplanted cohort, 39.5% of patients with ppFEV1<40% were hospitalised with oxygen verses 3.2% with ppFEV >70%: a 17-fold increase in odds. Worse outcomes were independently associated with older age, non-white race, underweight body mass index, and CF-related diabetes. Prescription of highly effective CFTR modulator therapies was associated with a significantly reduced odds of being hospitalised with oxygen (AOR 0.43 95%CI 0.31-0.60 p<0.001). Transplanted patients were hospitalised with supplemental oxygen therapy (21.9%) more often than non-transplanted (8.8%) and was independently associated with the primary outcome (Adjusted OR 2.45 95%CI 1.27-4.71 p=0.007).\n\nThis is the first study to show that there is a protective effect from the use of CFTR modulator therapy and that people with CF from an ethnic minority are at more risk of severe infection with SARS-CoV-2.", "doi": "10.1016/j.jcf.2022.06.006", "pmid": "35753987", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1569-1993(22)00593-8"}, {"db": "pmc", "key": "PMC9189103"}], "notes": [], "created": "2022-08-19T05:39:10.105Z", "modified": "2022-08-19T05:39:10.118Z"}, {"entity": "publication", "iuid": "2736ce22a4c84406aff2878bf7382293", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2736ce22a4c84406aff2878bf7382293.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2736ce22a4c84406aff2878bf7382293"}}, "title": "Evaluation of a pneumonia multiplex PCR panel for detection of bacterial respiratory tract pathogens from serial specimens collected from hospitalized COVID-19 patients.", "authors": [{"family": "Tellapragada", "given": "Chaitanya", "initials": "C"}, {"family": "Ydsten", "given": "Karin Andersson", "initials": "KA"}, {"family": "Ternhag", "given": "Anders", "initials": "A"}, {"family": "Giske", "given": "Christian G", "initials": "CG"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Eur J Clin Microbiol Infect Dis", "issn": "1435-4373", "volume": "41", "issue": "7", "pages": "1093-1098", "issn-l": null}, "abstract": "We investigated the concordance between the Unyvero Hospitalized Pneumonia (HPN) application and quantitative culture for detection of bacterial pathogens from serial lower respiratory tract (LRT) specimens collected from the same subject. Comparison of results from HPN application and culture was evaluated using 69 LRT samples from 27 subjects, using two evaluation approaches. False positive detections by the HPN application was 29% (20/69) in Evaluation I vs 10% (7/68) in Evaluation II. Additional pathogens detected by the HPN application could be confirmed in many instances by culture positivity for the same organism from previous or subsequent samples from the same subject.", "doi": "10.1007/s10096-022-04466-9", "pmid": "35727430", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10096-022-04466-9"}, {"db": "pmc", "key": "PMC9210330"}], "notes": [], "created": "2022-08-17T13:05:50.911Z", "modified": "2022-08-17T13:05:50.925Z"}, {"entity": "publication", "iuid": "6df11f853339494a86fd28b53ff34350", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6df11f853339494a86fd28b53ff34350.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6df11f853339494a86fd28b53ff34350"}}, "title": "Estimation of COVID-19 vaccine effectiveness against hospitalisation in individuals aged \u2265 65 years using electronic health registries; a pilot study in four EU/EEA countries, October 2021 to March 2022.", "authors": [{"family": "Sent\u00eds", "given": "Alexis", "initials": "A"}, {"family": "Kislaya", "given": "Irina", "initials": "I"}, {"family": "Nicolay", "given": "Nathalie", "initials": "N"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}, {"family": "Starrfelt", "given": "Jostein", "initials": "J"}, {"family": "Mart\u00ednez-Baz", "given": "Iv\u00e1n", "initials": "I"}, {"family": "Castilla", "given": "Jes\u00fas", "initials": "J"}, {"family": "Nielsen", "given": "Katrine Finderup", "initials": "KF"}, {"family": "Hansen", "given": "Christian Holm", "initials": "CH"}, {"family": "Emborg", "given": "Hanne-Dorthe", "initials": "HD"}, {"family": "Nardone", "given": "Anthony", "initials": "A"}, {"family": "Derrough", "given": "Tarik", "initials": "T"}, {"family": "Valenciano", "given": "Marta", "initials": "M"}, {"family": "Nunes", "given": "Baltazar", "initials": "B"}, {"family": "Monge", "given": "Susana", "initials": "S"}, {"family": "VEBIS-Lot4 working group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "27", "issue": "30", "issn-l": null}, "abstract": "By employing a common protocol and data from electronic health registries in Denmark, Navarre (Spain), Norway and Portugal, we estimated vaccine effectiveness (VE) against hospitalisation due to COVID-19 in individuals aged \u2265 65 years old, without previous documented infection, between October 2021 and March 2022. VE was higher in 65-79-year-olds compared with \u2265 80-year-olds and in those who received a booster compared with those who were primary vaccinated. VE remained high (ca 80%) between \u2265 12 and < 24 weeks after the first booster administration, and after Omicron became dominant.", "doi": "10.2807/1560-7917.ES.2022.27.30.2200551", "pmid": "35904059", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9336167"}], "notes": [], "created": "2022-08-12T08:31:50.769Z", "modified": "2022-08-12T08:31:50.775Z"}, {"entity": "publication", "iuid": "257be128e37140f4add47ae92431b41f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/257be128e37140f4add47ae92431b41f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/257be128e37140f4add47ae92431b41f"}}, "title": "Digital tools in allergy and respiratory care.", "authors": [{"family": "Verhoeven", "given": "Elisabeth", "initials": "E"}, {"family": "Rouadi", "given": "Philip", "initials": "P"}, {"family": "Jaoude", "given": "Eliane Abou", "initials": "EA"}, {"family": "Abouzakouk", "given": "Mohamed", "initials": "M"}, {"family": "Ansotegui", "given": "Ignacio", "initials": "I"}, {"family": "Al-Ahmad", "given": "Mona", "initials": "M"}, {"family": "Al-Nesf", "given": "Maryam Ali", "initials": "MA"}, {"family": "Azar", "given": "Cecilio", "initials": "C"}, {"family": "Bahna", "given": "Sami", "initials": "S"}, {"family": "Cuervo-Pardo", "given": "Lyda", "initials": "L"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}, {"family": "Douagui", "given": "Habib", "initials": "H"}, {"family": "Maximiliano G\u00f3mez", "given": "R", "initials": "R"}, {"family": "D\u00edaz", "given": "Sandra Gonz\u00e1lez", "initials": "SG"}, {"family": "Han", "given": "Joseph K", "initials": "JK"}, {"family": "Idriss", "given": "Samar", "initials": "S"}, {"family": "Irani", "given": "Carla", "initials": "C"}, {"family": "Karam", "given": "Marilyn", "initials": "M"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Nsouli", "given": "Talal", "initials": "T"}, {"family": "Scadding", "given": "Glenis", "initials": "G"}, {"family": "Senior", "given": "Brent", "initials": "B"}, {"family": "Smith", "given": "Pete", "initials": "P"}, {"family": "Y\u00e1\u00f1ez", "given": "Anah\u00ed", "initials": "A"}, {"family": "Zaitoun", "given": "Fares", "initials": "F"}, {"family": "Hellings", "given": "Peter W", "initials": "PW"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "World Allergy Organ J", "issn": "1939-4551", "volume": "15", "issue": "7", "pages": "100661", "issn-l": "1939-4551"}, "abstract": "Patient care in the allergy and respiratory fields is advancing rapidly, offering the possibility of the inclusion of a variety of digital tools that aim to improve outcomes of care. Impaired access to several health care facilities during the COVID-19 pandemic has considerably increased the appetite and need for the inclusion of e-health tools amongst end-users. Consequently, a multitude of different e-health tools have been launched worldwide with various registration and access options, and with a wide range of offered benefits. From the perspective of both patients and healthcare providers (HCPs), as well as from a legal and device-related perspective, several features are important for the acceptance, effectiveness,and long-term use of e-health tools. Patients and physicians have different needs and expectations of how digital tools might be of help in the care pathway. There is a need for standardization by defining quality assurance criteria. Therefore, the Upper Airway Diseases Committee of the World Allergy Organization (WAO) has taken the initiative to define and propose criteria for quality, appeal, and applicability of e-health tools in the allergy and respiratory care fields from a patient, clinician, and academic perspective with the ultimate aim to improve patient health and outcomes of care.", "doi": "10.1016/j.waojou.2022.100661", "pmid": "35784945", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1939-4551(22)00037-0"}, {"db": "pmc", "key": "PMC9243254"}], "notes": [], "created": "2022-08-17T13:10:51.707Z", "modified": "2022-08-17T13:10:51.720Z"}, {"entity": "publication", "iuid": "9cb40d5b1e9c472380fa0a51dd85c534", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9cb40d5b1e9c472380fa0a51dd85c534.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9cb40d5b1e9c472380fa0a51dd85c534"}}, "title": "Acute odynophagia: A new symptom of COVID-19 during the SARS-CoV-2 Omicron variant wave in Sweden.", "authors": [{"family": "Piersiala", "given": "Krzysztof", "initials": "K", "orcid": "0000-0003-3711-8371", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a8e2fbec7bb40ef8c1124526d3ac846.json"}}, {"family": "Kakabas", "given": "Lara", "initials": "L"}, {"family": "Bruckova", "given": "Anna", "initials": "A"}, {"family": "Starkhammar", "given": "Magnus", "initials": "M"}, {"family": "Cardell", "given": "Lars Olaf", "initials": "LO"}], "type": "case reports", "published": "2022-07-00", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": "292", "issue": "1", "pages": "154-161", "issn-l": null}, "abstract": "The objective of this study is to present a novel clinical manifestation of infection with the Omicron variant of the SARS-CoV-2 virus affecting mainly young, vaccinated, and healthy adults. We describe a new group of COVID-19 patients seeking emergency care with symptoms similar to the life-threatening condition epiglottitis. Here, we present a case series and discuss management.\n\nWe performed a retrospective single-center case study of patients diagnosed with COVID-19 who were referred to the Ear, Nose, and Throat Emergency Department (ENT ED) between January 1 and January 23, 2022 with clinical symptoms such as acute odynophagia, severe sore throat, and fever. Ethical approval was obtained from the Swedish Ethical Review Authority (2020-02579). Informed consent was obtained from all patients included in the study.\n\nTwenty patients meeting inclusion criteria were identified. Fifteen patients were fully vaccinated against COVID-19. Four patients needed a short hospitalization for their symptoms. The most common diagnoses were COVID-19-associated acute viral laryngotracheitis and/or viral pharyngitis. Six patients presented with signs of secondary bacterial infection and were put on antibiotics.\n\nPrevious variants of SARS-CoV-2 infection affected predominantly the lower respiratory tract and were associated with loss of smell and taste in many patients. The Omicron variant seems to affect predominantly the upper airways and cause acute laryngitis without olfactory dysfunction. In some patients, the clinical manifestation is similar to the symptoms of epiglottitis. In such a case, a prompt examination of the larynx is the gold standard to exclude inflammatory edema in the upper airways. None of the patients described in this study developed epiglottitis. In this study, we discuss the management of acute odynophagia in COVID-19 patients.", "doi": "10.1111/joim.13470", "pmid": "35170099", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Omicron VoC": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC9115132"}], "notes": [], "created": "2023-07-13T11:25:59.766Z", "modified": "2023-07-13T11:25:59.881Z"}, {"entity": "publication", "iuid": "b1afaead4b2549a896f087c73a1b5421", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1afaead4b2549a896f087c73a1b5421.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1afaead4b2549a896f087c73a1b5421"}}, "title": "A Qualitative Serial Analysis of Drawings by Thirteen-to Fifteen-Year-Old Adolescents in Sweden About the First Wave of the Covid-19 Pandemic.", "authors": [{"family": "Tishelman", "given": "Carol", "initials": "C", "orcid": "0000-0003-4161-0342", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1fbfdb57e5124e72bcffcce93b21fa05.json"}}, {"family": "Degen", "given": "Johanna L", "initials": "JL", "orcid": "0000-0002-0530-1385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c045049dcce40d8acc195b696cda010.json"}}, {"family": "Weiss Goitiand\u00eda", "given": "Sof\u00eda", "initials": "S", "orcid": "0000-0001-6538-0786", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5a80a546baf4241a238dd3850dbb9dc.json"}}, {"family": "Kleijberg", "given": "Max", "initials": "M", "orcid": "0000-0003-4036-707X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8087207bbaa34fdc896906ea11ada0fc.json"}}, {"family": "Kleeberg-Niepage", "given": "Andrea", "initials": "A", "orcid": "0000-0002-2433-8714", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fad2466bf73045b48d00493c9ea0ab4a.json"}}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Qual Health Res", "issn": "1049-7323", "pages": "1370-1385", "volume": "32", "issue": "8-9", "issn-l": null}, "abstract": "In this article, we explore the perspectives of 13-15-year-olds living in Sweden about the first wave of the Covid-19 pandemic, through inductive analysis of 187 of their drawings. Through reconstructive serial picture analysis, three types of meaning were derived: (1) A new normal in dystopian scenery points to the disruption of daily life and development of new praxis and meaning in a context of threat and restriction; (2) Disrupted relationships refers to these adolescents' self-portrayal as solitary, without adult guidance or friends prominent; and (3) Negative emotions and compliant behaviors addresses a range of negative emotions and expressions of loss with few proactive strategies illustrated. General existential distress appears in these drawings, seemingly compounded by both developmental stage and other factors in addition to the pandemic context. Drawings suggest a restricted repertoire of ways of dealing with challenges confronting these adolescents, who seemed to feel left to their own resources.", "doi": "10.1177/10497323221101978", "pmid": "35599585", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9350847"}], "notes": [], "created": "2022-06-21T17:58:05.053Z", "modified": "2023-01-13T14:48:28.475Z"}, {"entity": "publication", "iuid": "91af983740274e2e8242aa0949ed018e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/91af983740274e2e8242aa0949ed018e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/91af983740274e2e8242aa0949ed018e"}}, "title": "The Relationship between COVID-19 and Hypothalamic-Pituitary-Adrenal Axis: A Large Spectrum from Glucocorticoid Insufficiency to Excess-The CAPISCO International Expert Panel.", "authors": [{"family": "Jensterle", "given": "Mojca", "initials": "M", "orcid": "0000-0002-8861-8803", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59986ccac1b64e869ae0bd6761209852.json"}}, {"family": "Herman", "given": "Rok", "initials": "R", "orcid": "0000-0002-6053-5686", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff3ab4ee68944de5b693af679f9ca8df.json"}}, {"family": "Jane\u017e", "given": "Andrej", "initials": "A", "orcid": "0000-0002-6594-5254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43670b2197b8438e85feec7094864ce5.json"}}, {"family": "Mahmeed", "given": "Wael Al", "initials": "WA", "orcid": "0000-0003-0312-9910", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/263122e48a624950a78cfa8d0aca83bd.json"}}, {"family": "Al-Rasadi", "given": "Khalid", "initials": "K", "orcid": "0000-0003-0460-1236", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa65f0bc61f44c47860a15aa8b7eba15.json"}}, {"family": "Al-Alawi", "given": "Kamila", "initials": "K"}, {"family": "Banach", "given": "Maciej", "initials": "M"}, {"family": "Banerjee", "given": "Yajnavalka", "initials": "Y", "orcid": "0000-0002-7546-8893", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d8dea02972d4523816d940a6e0d2fb6.json"}}, {"family": "Ceriello", "given": "Antonio", "initials": "A"}, {"family": "Cesur", "given": "Mustafa", "initials": "M", "orcid": "0000-0002-1029-2604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b6591ae68a0442cfba8dbca9f28d9104.json"}}, {"family": "Cosentino", "given": "Francesco", "initials": "F"}, {"family": "Galia", "given": "Massimo", "initials": "M"}, {"family": "Goh", "given": "Su-Yen", "initials": "SY"}, {"family": "Kalra", "given": "Sanjay", "initials": "S"}, {"family": "Kempler", "given": "Peter", "initials": "P"}, {"family": "Lessan", "given": "Nader", "initials": "N", "orcid": "0000-0001-9147-0961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6fe7d1c124a4a349038f540cbf6721f.json"}}, {"family": "Lotufo", "given": "Paulo", "initials": "P"}, {"family": "Papanas", "given": "Nikolaos", "initials": "N", "orcid": "0000-0002-7320-785X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/540620683a4749568584a98e68dc73ed.json"}}, {"family": "Rizvi", "given": "Ali A", "initials": "AA", "orcid": "0000-0002-3714-0790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ab189188b8e4543aafa50f2422c70ea.json"}}, {"family": "Santos", "given": "Raul D", "initials": "RD"}, {"family": "Stoian", "given": "Anca P", "initials": "AP", "orcid": "0000-0003-0555-526X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0aef0cbf4cae4db68b4248baf9a8da4e.json"}}, {"family": "Toth", "given": "Peter P", "initials": "PP", "orcid": "0000-0001-5810-5460", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c17462263aef48dd8f61914bedb1a9a2.json"}}, {"family": "Viswanathan", "given": "Vijay", "initials": "V"}, {"family": "Rizzo", "given": "Manfredi", "initials": "M", "orcid": "0000-0002-9549-8504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d888593722ae4ba2b12a04effd67eaff.json"}}], "type": "journal article", "published": "2022-06-30", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "23", "issue": "13", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) is a highly heterogeneous disease regarding severity, vulnerability to infection due to comorbidities, and treatment approaches. The hypothalamic-pituitary-adrenal (HPA) axis has been identified as one of the most critical endocrine targets of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that might significantly impact outcomes after infection. Herein we review the rationale for glucocorticoid use in the setting of COVID-19 and emphasize the need to have a low index of suspicion for glucocorticoid-induced adrenal insufficiency, adjusting for the glucocorticoid formulation used, dose, treatment duration, and underlying health problems. We also address several additional mechanisms that may cause HPA axis dysfunction, including critical illness-related corticosteroid insufficiency, the direct cytopathic impacts of SARS-CoV-2 infection on the adrenals, pituitary, and hypothalamus, immune-mediated inflammations, small vessel vasculitis, microthrombotic events, the resistance of cortisol receptors, and impaired post-receptor signaling, as well as the dissociation of ACTH and cortisol regulation. We also discuss the increased risk of infection and more severe illness in COVID-19 patients with pre-existing disorders of the HPA axis, from insufficiency to excess. These insights into the complex regulation of the HPA axis reveal how well the body performs in its adaptive survival mechanism during a severe infection, such as SARS-CoV-2, and how many parameters might disbalance the outcomes of this adaptation.", "doi": "10.3390/ijms23137326", "pmid": "35806331", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijms23137326"}, {"db": "pmc", "key": "PMC9266848"}], "notes": [], "created": "2022-08-17T10:41:22.987Z", "modified": "2022-08-17T10:42:24.138Z"}, {"entity": "publication", "iuid": "01e843d52d084c7dbf5d8b9e20438faf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01e843d52d084c7dbf5d8b9e20438faf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01e843d52d084c7dbf5d8b9e20438faf"}}, "title": "Self-Assessed Aspects of Health 3 Months after COVID-19 Hospitalization-A Swedish Cross-Sectional Study.", "authors": [{"family": "Larsson", "given": "Alexandra C", "initials": "AC", "orcid": "0000-0001-9100-4071", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8532302825d744c7b29ccefeb16e11e2.json"}}, {"family": "Engwall", "given": "Marie", "initials": "M"}, {"family": "Palstam", "given": "Annie", "initials": "A", "orcid": "0000-0002-7127-213X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b127bce23f5545a5a17354e60b780f86.json"}}, {"family": "Persson", "given": "Hanna C", "initials": "HC", "orcid": "0000-0001-8633-3292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc8035c749ab4521b549ea820f6b4389.json"}}], "type": "journal article", "published": "2022-06-30", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "13", "issn-l": null}, "abstract": "It is not yet fully understood how the patients self-assess their overall health in the early recovery after COVID-19 and if certain patient groups are more prominent in perceived long-time effects of COVID-19. The aim of this study was to describe self-assessed aspects of health in body function, activity and participation 3 months after hospitalization due to COVID-19 and identify difference between groups depending in age, sex and level of hospital care. This cross-sectional study consists of self-assessed aspects of health and recovery in 168 participants (mean age 64 years old, 69% men) previously hospitalized patients due to COVID-19. We have previously published data, from hospital discharge, on this cohort were predominantly the older patients and previous ICU-treated participants were affected. In this study there were differences in between groups. Of the study population 72% perceived fatigue, 64% respiratory difficulties, 37% perceived symptoms of anxiety. Three-months after COVID-19 this cohort was overall still affected. The recovery process is multifaced and the cohort heterogeneous, hence the rehabilitation needs to be highly individualized, and the follow-up of this patient group is of importance regardless of age, sex and previous level of hospital care.", "doi": "10.3390/ijerph19138020", "pmid": "35805677", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19138020"}, {"db": "pmc", "key": "PMC9265939"}], "notes": [], "created": "2022-08-17T10:42:51.136Z", "modified": "2022-08-17T10:42:51.223Z"}, {"entity": "publication", "iuid": "4b1e5771831f45e5a86dff2c0d89c457", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b1e5771831f45e5a86dff2c0d89c457.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b1e5771831f45e5a86dff2c0d89c457"}}, "title": "Face mask-induced purpura: another unexpected effect of COVID era.", "authors": [{"family": "Piccolo", "given": "V", "initials": "V", "orcid": "0000-0001-7798-4368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1ddb3ce197e446dbc8156e8e3222d5e.json"}}, {"family": "Bassi", "given": "A", "initials": "A", "orcid": "0000-0002-9157-5189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2628d4790c0041b19e8bf037d259ed99.json"}}, {"family": "Mazzatenta", "given": "C", "initials": "C"}, {"family": "Russo", "given": "T", "initials": "T"}, {"family": "Argenziano", "given": "G", "initials": "G", "orcid": "0000-0003-1413-8214", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7fd2179bdb540a784d26cd05f39b77d.json"}}, {"family": "Cutrone", "given": "M", "initials": "M"}, {"family": "Danielsson Darlington", "given": "Markus Es", "initials": "ME"}, {"family": "Grimalt", "given": "R", "initials": "R", "orcid": "0000-0001-7204-8626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b47bbd772ef942cb87ee26fe24e0e0e7.json"}}], "type": "letter", "published": "2022-06-30", "journal": {"title": "J Eur Acad Dermatol Venereol", "issn": "1468-3083", "issn-l": null}, "abstract": null, "doi": "10.1111/jdv.18392", "pmid": "35771119", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9349894"}], "notes": [], "created": "2022-08-19T05:31:31.758Z", "modified": "2022-08-19T05:31:31.879Z"}, {"entity": "publication", "iuid": "5d844d0935554a7f8d3faadc2065998f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d844d0935554a7f8d3faadc2065998f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d844d0935554a7f8d3faadc2065998f"}}, "title": "Development of nurse-led videoconference-delivered cognitive behavioural therapy for domestic violence: Feasibility and acceptability.", "authors": [{"family": "Nesset", "given": "Merete Berg", "initials": "MB", "orcid": "0000-0003-4582-8349", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1fe1e4abc6f546ee8a1071eff3ae456f.json"}}, {"family": "Lauvrud", "given": "Christian", "initials": "C"}, {"family": "Meisingset", "given": "Anne", "initials": "A"}, {"family": "Nyhus", "given": "Eskil", "initials": "E"}, {"family": "Palmstierna", "given": "Tom", "initials": "T"}, {"family": "Lara-Cabrera", "given": "Mariela Loreto", "initials": "ML", "orcid": "0000-0002-7342-9049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bdee466c211435486b6f62b2940e473.json"}}], "type": "journal article", "published": "2022-06-30", "journal": {"title": "J Adv Nurs", "issn": "1365-2648", "issn-l": null}, "abstract": "Because of the COVID-19 lockdown, an internet-based adaption of a nurse-led cognitive behavioural group therapy (CGBT) was provided for perpetrators of domestic violence. The aim of this study was to describe the development of the therapy, examine the initial feasibility and impact on patient satisfaction of the programme and evaluate the associated patient-reported experiences.\n\nProgramme development as well as testing its feasibility and acceptability using cross-sectional survey data.\n\nAnonymous data were collected at a university hospital in Norway between October and December 2021. Feasibility was examined by comparing the numbers of patients who agreed to participate, chose not to participate or dropped out during the intervention. There was a self-reporting scale that evaluated patient satisfaction, and the participants were invited to make suggestions for improvement of the intervention. The results of the study are reported in accordance with the STROBE checklist.\n\nThe videoconference-delivered CGBT was feasible. Two of the 67 patients refused to attend therapy delivered in a remote manner (3.0%), and four patients (6.0%) were classified as non-completers. Overall, patients were satisfied with the therapy.\n\nThis study described a promising nurse-led internet-based intervention for individuals who were domestically violent and had voluntarily sought healthcare help. The participants' satisfaction with the intervention indicates its acceptability and feasibility. However, research on internet-based cognitive behaviour therapy is still in its infancy. These results may guide the future development of internet-based cognitive behavioural therapy (CBT) for individuals who perpetrate domestic violence. Further research is needed on the pros and cons of this mode of service delivery.\n\nThis study addressed the challenges of providing treatment for domestic violence during the COVID-19 pandemic by examining videoconference-delivered CBT for individuals who perpetrate domestic violence.", "doi": "10.1111/jan.15347", "pmid": "35774003", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-17T13:13:56.417Z", "modified": "2022-08-17T13:13:56.503Z"}, {"entity": "publication", "iuid": "23fd55e2b4e14e789737af66351eff51", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23fd55e2b4e14e789737af66351eff51.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23fd55e2b4e14e789737af66351eff51"}}, "title": "Development Work in Swedish Eldercare: Resources for Trustworthy, Integrated Managerial Work During the COVID-19 Pandemic.", "authors": [{"family": "Dellve", "given": "Lotta", "initials": "L"}, {"family": "Williamsson", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-06-30", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "10", "pages": "864272", "issn-l": "2296-2565"}, "abstract": "The extensive needs for developments of eldercare addressing working conditions, care quality, influence, and safety was highlighted during the pandemic. This mixed-method study contribute with knowledge about capability-strengthening development work and its importance for trustworthy managerial work, before and during the COVID-19 pandemic. Questionnaire data and narratives from first-line managers immediately before (n = 284) and 16 months into the pandemic (n = 189), structured interviews with development leaders (n = 25), and documents were analyzed. The results identify different focuses of development work. Strategic-level development leaders focused the strengthening of old adults' capabilities. While operational-level leaders approached strengthening employees' capability. First-line managers' rating of their trustworthy managerial work decreased during the pandemic and was associated with their workload, development support and capability-strengthening projects focusing employees' resources. The study demonstrates the gap between strategic and the operational levels regarding understanding of capability set and needed resources for strengthening capabilities and trustworthy, integrated managerial work regarding safety, influence, and quality conditions for old adults and employees.", "doi": "10.3389/fpubh.2022.864272", "pmid": "35844876", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9280882"}], "notes": [], "created": "2022-08-12T08:53:45.557Z", "modified": "2022-08-12T08:53:45.564Z"}, {"entity": "publication", "iuid": "c29c572267d64128b2d27af013aba852", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c29c572267d64128b2d27af013aba852.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c29c572267d64128b2d27af013aba852"}}, "title": "Mitochondrial dysfunction is associated with lipid metabolism disorder and upregulation of angiotensin-converting enzyme 2.", "authors": [{"family": "Zhao", "given": "Qian", "initials": "Q", "orcid": "0000-0001-9218-9506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd48776ed26440f9a727f785cbd98b38.json"}}, {"family": "Zhou", "given": "Xiaoshan", "initials": "X"}, {"family": "Kuiper", "given": "Raoul", "initials": "R"}, {"family": "Curbo", "given": "Sophie", "initials": "S"}, {"family": "Karlsson", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-06-29", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "6", "pages": "e0270418", "issn-l": "1932-6203"}, "abstract": "Thymidine kinase 2 (TK2) deficiency in humans leads to a myopathic form of mitochondrial DNA (mtDNA) deficiency. Here we present a skeletal and cardiac muscle specific TK2 knockout mouse (mTk2 KO). The mice showed dilated hearts and markedly reduced adipose tissue during week 12 to 16. A severe decrease of mtDNA was found only in skeletal muscle and heart tissue in mTk2 KO mice. Expression analysis of key metabolic genes of 16 weeks knockout mice showed significant changes of genes involved in lipid metabolism, with different patterns in heart and skeletal muscle. Our study further suggests that lipoprotein lipase (LPL) from liver supports the metabolism when heart and skeletal muscle were impaired due to mitochondrial dysfunction. The angiotensin-converting enzyme 2 (ACE2), which is involved in glucose homeostasis, was also affected by mtDNA deficiency in our study. Interestingly, both the gene and protein expression of ACE2 were increased in cardiac tissue of mTk2 KO mice. Since ACE2 is a receptor for the SARS-CoV-2 virus, its regulation in relation to mitochondrial function may have important clinical implications.", "doi": "10.1371/journal.pone.0270418", "pmid": "35767531", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-31565"}, {"db": "pmc", "key": "PMC9242481"}], "notes": [], "created": "2022-08-19T05:32:55.634Z", "modified": "2022-08-19T05:32:55.692Z"}, {"entity": "publication", "iuid": "c7ee9a93593848aea5b72f76cf9d6a2a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7ee9a93593848aea5b72f76cf9d6a2a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7ee9a93593848aea5b72f76cf9d6a2a"}}, "title": "Elementary School Teachers' Perceptions of COVID-19-Related Restrictions on Food Allergy Management.", "authors": [{"family": "Santos", "given": "Mae Jhelene L", "initials": "MJL"}, {"family": "Riediger", "given": "Natalie", "initials": "N", "orcid": "0000-0002-8736-9446", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc59a9c00b1b4d4cb2cbb391b115a789.json"}}, {"family": "Abrams", "given": "Elissa M", "initials": "EM"}, {"family": "Piquemal", "given": "Nathalie", "initials": "N"}, {"family": "Protudjer", "given": "Jennifer L P", "initials": "JLP", "orcid": "0000-0002-3888-8688", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e35d8fddae04acbb44382b43acb0147.json"}}], "type": "journal article", "published": "2022-06-29", "journal": {"title": "Nutrients", "issn": "2072-6643", "volume": "14", "issue": "13", "issn-l": null}, "abstract": "(1) Background: Approximately 7% of Canadian children live with a food allergy (FA). Pre-COVID-19, ~20% of anaphylactic reactions occurred in schools. Yet, teachers reported poor FA-related knowledge, and experiences during the COVID-19 pandemic are not well-studied. Additionally, teachers' management approaches vary widely. We aimed to describe elementary school teachers' perceptions about FA management during the COVID-19 pandemic; (2) Methods: Using a semi-structured interview guide, English-speaking elementary school teachers in Winnipeg, Canada were interviewed virtually. Interviews were audio-recorded and transcribed verbatim. Data were analysed thematically; (3) Results: Most teachers were female and taught in public schools. Two themes were identified. Theme 1, COVID-19 restrictions made mealtimes more manageable, capturing the positive impacts of pandemic restrictions such as seating arrangements and enhanced cleaning. Limited lunchtime supervision prompted some teachers to assume this role. Theme 2, Food allergy management was indirectly adapted to fit changing COVID-19 restrictions, describing how changing restrictions influenced FA-related practices. FA training was offered virtually with less nursing support. Class cohorts and remote learning decreased teachers' perceived risk and FA-related management responsibility; (4) Conclusions: COVID-19-related practices were perceived as positively influencing in-school FA management, although unintended consequences, such as increased supervisory roles for teachers and reduced nursing support, were described.", "doi": "10.3390/nu14132714", "pmid": "35807894", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "nu14132714"}, {"db": "pmc", "key": "PMC9268574"}], "notes": [], "created": "2022-08-17T10:41:54.202Z", "modified": "2022-08-17T10:42:02.391Z"}, {"entity": "publication", "iuid": "9bc47c462b2e4d38ad40b313692930b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9bc47c462b2e4d38ad40b313692930b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9bc47c462b2e4d38ad40b313692930b3"}}, "title": "Citizens' Use of eHealth Services During COVID-19 in Relation to National Policy Goals.", "authors": [{"family": "Koch", "given": "Sabine", "initials": "S"}, {"family": "Vimarlund", "given": "Vivian", "initials": "V"}], "type": "journal article", "published": "2022-06-29", "journal": {"title": "Stud Health Technol Inform", "issn": "1879-8365", "volume": "295", "pages": "12-15", "issn-l": null}, "abstract": "The main goals of the Swedish eHealth strategy are to enable citizens to achieve good and equal health and welfare, and to support self-determination and increased participation in society. We analyzed the relationship between these goals and the use of eHealth services offered for citizens prior to and during the COVID-19 pandemic. Data was collected through a national citizen survey issued in 2019 and 2021 to a sample size of 15.000 representative individuals each. Results showed that the use of eHealth services was highest in the 30-49 years age group and among respondents with high education. There were no major differences between respondents with high, medium, or low income, and neither between respondents with different degrees of self-perceived health, nor between native Swedish and non-Swedish respondents. Changes in use of different eHealth services over time were most probably related to the pandemic and are not significant. All age groups showed a similar relative increase regarding their use of eHealth services, except when searching the Internet for diagnosis and treatment where persons above 75 years of age had the largest increase. Most significant were the increase in online visits and the decrease in maintaining health, training, or food diaries. Strategic goals related to equity seem to be partly met as eHealth services are used to the same degree by different socio-economic groups. However, the older population uses eHealth services less than other age groups and a deeper understanding of the relationship between specific services and their impact on strategic goals is needed.", "doi": "10.3233/SHTI220647", "pmid": "35773793", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "SHTI220647"}], "notes": [], "created": "2022-08-17T13:14:11.436Z", "modified": "2022-08-17T13:14:11.466Z"}, {"entity": "publication", "iuid": "3a05f12e943b40df96ed49f68db01114", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a05f12e943b40df96ed49f68db01114.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a05f12e943b40df96ed49f68db01114"}}, "title": "Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2021.", "authors": [{"family": "Ikonomou", "given": "Laertis", "initials": "L"}, {"family": "Magnusson", "given": "Mattias", "initials": "M"}, {"family": "Dries", "given": "Ruben", "initials": "R"}, {"family": "Herzog", "given": "Erica L", "initials": "EL"}, {"family": "Hynds", "given": "Robert", "initials": "R"}, {"family": "Borok", "given": "Zea", "initials": "Z"}, {"family": "Park", "given": "Jin-Ah", "initials": "JA"}, {"family": "Skolasinski", "given": "Steven", "initials": "S"}, {"family": "Burgess", "given": "Janette K", "initials": "JK"}, {"family": "Turner", "given": "Leigh", "initials": "L"}, {"family": "Mojarad", "given": "Sarah M", "initials": "SM"}, {"family": "Mahoney", "given": "John E", "initials": "JE"}, {"family": "Lynch", "given": "Thomas", "initials": "T"}, {"family": "Lehmann", "given": "Mareike", "initials": "M"}, {"family": "Thannickal", "given": "Victor J", "initials": "VJ"}, {"family": "Hook", "given": "Jaime L", "initials": "JL"}, {"family": "Vaughan", "given": "Andrew E", "initials": "AE"}, {"family": "Hoffman", "given": "Evan T", "initials": "ET"}, {"family": "Weiss", "given": "Daniel J", "initials": "DJ"}, {"family": "Ryan", "given": "Amy L", "initials": "AL"}], "type": "journal article", "published": "2022-06-28", "journal": {"title": "Am J Physiol Lung Cell Mol Physiol", "issn": "1522-1504", "issn-l": null}, "abstract": "The 9th biennial conference titled \"Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases\" was hosted virtually, due to the ongoing COVID-19 pandemic, in collaboration with the University of Vermont Larner College of Medicine, the National Heart, Lung, and Blood Institute, the Alpha-1 Foundation, the Cystic Fibrosis Foundation, and the International Society for Cell & Gene Therapy. The event was held from July 12th through 15th, 2021 with a pre-conference workshop held July 9th. As in previous years the objectives remained to review and discuss the status of active research areas involving stem cells, cellular therapeutics, and bioengineering as they relate to the human lung. Topics included: 1) technological advancements in the in situ analysis of lung tissues, 2) new insights into stem cell signalling and plasticity in lung remodelling and regeneration, 3) the impact of extracellular matrix in stem cell regulation and airway engineering in lung regeneration, 4) differentiating and delivering stem cell therapeutics to the lung, 5) regeneration in response to viral infection, and 6) ethical development of cell-based treatments for lung diseases. This selection of topics represents some of the most dynamic and current research areas in lung biology. The virtual workshop included active discussion on state-of-the-art methods relating to the core features of the 2021 conference, including in-situ protemics, lung-on-chip, iPSC-airway differentiation, and light sheet microscopy. The conference concluded with an open discussion to suggest funding priorities and recommendations for future research directions in basic and translational lung biology.", "doi": "10.1152/ajplung.00113.2022", "pmid": "35762622", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-19T05:35:18.537Z", "modified": "2022-08-19T05:35:18.575Z"}, {"entity": "publication", "iuid": "d24b783fef17424e98d1271acb367c5b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d24b783fef17424e98d1271acb367c5b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d24b783fef17424e98d1271acb367c5b"}}, "title": "Low Prevalence of Mild Alpha-1-Antitrypsin Deficiency in Hospitalized COVID-19-Patients.", "authors": [{"family": "Nygren", "given": "David", "initials": "D", "orcid": "0000-0003-2426-7204", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d84ae6e240ec4a3caaf519a43f9d7cf9.json"}}, {"family": "M\u00f6lstad", "given": "Ulrica", "initials": "U"}, {"family": "Thulesius", "given": "Hans", "initials": "H", "orcid": "0000-0002-3785-5630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f7d45ab8dd94b89873fb2e44a0a8770.json"}}, {"family": "Hillman", "given": "Magnus", "initials": "M"}, {"family": "Broman", "given": "Lars Mikael", "initials": "LM", "orcid": "0000-0003-4124-4581", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6792bc7f2ba4afe931144a4a8a6bca9.json"}}, {"family": "Tanash", "given": "Hanan", "initials": "H"}, {"family": "Landin-Olsson", "given": "Mona", "initials": "M"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}, {"family": "Thunander", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2022-06-28", "journal": {"title": "Int J Gen Med", "issn": "1178-7074", "volume": "15", "pages": "5843-5848", "issn-l": null}, "abstract": "Alpha-1-antitrypsin (AAT) has been shown to inhibit SARS-CoV-2 cell entry and suggested as a therapeutic agent for COVID-19. Furthermore, epidemiological association of high prevalence of Alpha-1-antitrypsin deficiency (AATD) and regional severity of COVID-19-impact has been hypothesized. In our study setting, the estimated prevalence rates of mild (PI*MZ, PI*SS or PI*MS) and moderate-to-severe AATD (PI*ZZ or PI*SZ) are high, 9% and 0.2%, respectively. Our primary aim was to examine the prevalence rate of AATD among hospitalized COVID-19-patients.\n\nIn this prospective observational study, enrollment occurred from December 2020 to January 2021 in two COVID-19-units at Sk\u00e5ne University Hospital, Lund, Sweden. Case definition was a patient hospitalized due to COVID-19. Patients were screened for AATD with PI-typing and if results were inconclusive, PCR for the S- and Z-genes were performed. Patients were categorized as severe or moderate COVID-19 and 30-day-mortality data were collected. The primary outcome was prevalence rate of AATD. The secondary outcome investigated association between presence of mild AATD and severe COVID-19.\n\nWe enrolled 61 patients with COVID-19. Two patients out of 61 (3%) had mild AATD (PI*MZ) and none had moderate-to-severe AATD. 30/61 (49%) had severe COVID-19. Both patients with mild AATD developed severe COVID-19. Yet, presence of AATD was not significantly associated with severe COVID-19 (p=0.24).\n\nMild AATD (PI*MS or PI*MZ) was rare in a small cohort of hospitalized patients with COVID-19 in a study setting with a high background prevalence of AATD.", "doi": "10.2147/IJGM.S370434", "pmid": "35789772", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "370434"}, {"db": "pmc", "key": "PMC9250346"}], "notes": [], "created": "2022-08-17T13:08:54.738Z", "modified": "2022-08-17T13:08:54.844Z"}, {"entity": "publication", "iuid": "59dd4a10ac14474cab50fcc41b94cc76", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/59dd4a10ac14474cab50fcc41b94cc76.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/59dd4a10ac14474cab50fcc41b94cc76"}}, "title": "Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records.", "authors": [{"family": "Thompson", "given": "Ellen J", "initials": "EJ", "orcid": "0000-0003-2118-821X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6754739394b24a5c8f5db22905b22c3c.json"}}, {"family": "Williams", "given": "Dylan M", "initials": "DM", "orcid": "0000-0002-3825-2487", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8be5ce9d68b4fcb870f1dce11ccdaef.json"}}, {"family": "Walker", "given": "Alex J", "initials": "AJ", "orcid": "0000-0003-4932-6135", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/392cc8f956754fabbf68946bf8a3581a.json"}}, {"family": "Mitchell", "given": "Ruth E", "initials": "RE", "orcid": "0000-0002-3506-160X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cbf4d3aa699e4af69037e7539fb4497a.json"}}, {"family": "Niedzwiedz", "given": "Claire L", "initials": "CL", "orcid": "0000-0001-6133-4168", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9cf7719d211648ab98b572b231354e15.json"}}, {"family": "Yang", "given": "Tiffany C", "initials": "TC"}, {"family": "Huggins", "given": "Charlotte F", "initials": "CF"}, {"family": "Kwong", "given": "Alex S F", "initials": "ASF", "orcid": "0000-0003-1953-2771", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65ccb94351224dbdbcaa53d6ef6502ba.json"}}, {"family": "Silverwood", "given": "Richard J", "initials": "RJ", "orcid": "0000-0002-2744-1194", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d46ad9468444d3dbfbe8f392b9fb502.json"}}, {"family": "Di Gessa", "given": "Giorgio", "initials": "G", "orcid": "0000-0001-6154-1845", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c2319c222cc40069a5f55ead6d361f6.json"}}, {"family": "Bowyer", "given": "Ruth C E", "initials": "RCE", "orcid": "0000-0002-6941-8160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eebaf361c184499ca6729aa60cc0af3d.json"}}, {"family": "Northstone", "given": "Kate", "initials": "K"}, {"family": "Hou", "given": "Bo", "initials": "B"}, {"family": "Green", "given": "Michael J", "initials": "MJ", "orcid": "0000-0003-3193-2452", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84efba4af3264153b510906d0f4dcb35.json"}}, {"family": "Dodgeon", "given": "Brian", "initials": "B"}, {"family": "Doores", "given": "Katie J", "initials": "KJ", "orcid": "0000-0002-5507-1725", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d626ec20fb5d424e97a63b876f8cc5f5.json"}}, {"family": "Duncan", "given": "Emma L", "initials": "EL", "orcid": "0000-0002-8143-4403", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26eb842103da464986b66de7d7751548.json"}}, {"family": "Williams", "given": "Frances M K", "initials": "FMK", "orcid": "0000-0002-2998-2744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87a6db988c2e421f81fce7773436aefa.json"}}, {"family": "OpenSAFELY Collaborative", "given": "", "initials": ""}, {"family": "Steptoe", "given": "Andrew", "initials": "A", "orcid": "0000-0001-7808-4943", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/532fa7059d1941df934fb7c759a76057.json"}}, {"family": "Porteous", "given": "David J", "initials": "DJ", "orcid": "0000-0003-1249-6106", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8575eb112a94584aa4fc08ebf3b49b7.json"}}, {"family": "McEachan", "given": "Rosemary R C", "initials": "RRC"}, {"family": "Tomlinson", "given": "Laurie", "initials": "L", "orcid": "0000-0001-8848-9493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03f2034f701e46f3919a944d2ac325d7.json"}}, {"family": "Goldacre", "given": "Ben", "initials": "B"}, {"family": "Patalay", "given": "Praveetha", "initials": "P"}, {"family": "Ploubidis", "given": "George B", "initials": "GB"}, {"family": "Katikireddi", "given": "Srinivasa Vittal", "initials": "SV", "orcid": "0000-0001-6593-9092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9bcdfb6c28e742878e7df8ee66fa6863.json"}}, {"family": "Tilling", "given": "Kate", "initials": "K", "orcid": "0000-0002-1010-8926", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b5bd223d89f4d5cbfbf5decf107d5b9.json"}}, {"family": "Rentsch", "given": "Christopher T", "initials": "CT", "orcid": "0000-0002-1408-7907", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32d3afaa4b844ddb9ecc43e313b877ab.json"}}, {"family": "Timpson", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0002-7141-9189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90b26df69dcd46bd9f6e4eebbf46a36f.json"}}, {"family": "Chaturvedi", "given": "Nishi", "initials": "N", "orcid": "0000-0002-6211-2775", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94889a94593342f688fc89e9419ef7d0.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}], "type": "journal article", "published": "2022-06-28", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "3528", "issn-l": "2041-1723"}, "abstract": "The frequency of, and risk factors for, long COVID are unclear among community-based individuals with a history of COVID-19. To elucidate the burden and possible causes of long COVID in the community, we coordinated analyses of survey data from 6907 individuals with self-reported COVID-19 from 10 UK longitudinal study (LS) samples and 1.1 million individuals with COVID-19 diagnostic codes in electronic healthcare records (EHR) collected by spring 2021. Proportions of presumed COVID-19 cases in LS reporting any symptoms for 12+ weeks ranged from 7.8% and 17% (with 1.2 to 4.8% reporting debilitating symptoms). Increasing age, female sex, white ethnicity, poor pre-pandemic general and mental health, overweight/obesity, and asthma were associated with prolonged symptoms in both LS and EHR data, but findings for other factors, such as cardio-metabolic parameters, were inconclusive.", "doi": "10.1038/s41467-022-30836-0", "pmid": "35764621", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-022-30836-0"}, {"db": "pmc", "key": "PMC9240035"}], "notes": [], "created": "2022-08-19T05:34:48.695Z", "modified": "2022-08-19T05:34:49.333Z"}, {"entity": "publication", "iuid": "1a8957a53d6c4e6fb319f4649104f201", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1a8957a53d6c4e6fb319f4649104f201.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1a8957a53d6c4e6fb319f4649104f201"}}, "title": "Knowledge, Attitude, and Perception of Cancer Patients towards COVID-19 in Pakistan: A Cross-Sectional Study.", "authors": [{"family": "Khattak", "given": "Saadullah", "initials": "S", "orcid": "0000-0001-6798-2991", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/619a53d915304bab9bde893f36292393.json"}}, {"family": "Faheem", "given": "Muhammad", "initials": "M"}, {"family": "Nawaz", "given": "Bilawal", "initials": "B"}, {"family": "Khan", "given": "Maqbool", "initials": "M", "orcid": "0000-0001-7656-0184", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6328703e91874423a0344d277cdf4159.json"}}, {"family": "Khan", "given": "Nazeer Hussain", "initials": "NH", "orcid": "0000-0003-4380-233X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/965d14c87f584cefa64f774f34d0f711.json"}}, {"family": "Ullah", "given": "Nadeem", "initials": "N", "orcid": "0000-0001-6089-8906", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69e0776f1bec447ab4b94b7277ceb178.json"}}, {"family": "Khan", "given": "Taj Ali", "initials": "TA"}, {"family": "Khan", "given": "Rahat Ullah", "initials": "RU", "orcid": "0000-0002-7109-6201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ba9d38e92be45a18c3a95c9fc82fc93.json"}}, {"family": "Haleem", "given": "Kashif Syed", "initials": "KS"}, {"family": "Ren", "given": "Zhi-Guang", "initials": "ZG"}, {"family": "Wu", "given": "Dong-Dong", "initials": "DD"}, {"family": "Ji", "given": "Xin-Ying", "initials": "XY"}], "type": "journal article", "published": "2022-06-28", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "13", "issn-l": null}, "abstract": "Cancer patients, being immunocompromised, are at higher risk of coronavirus disease (COVID-19). The current study determines cancer patients' knowledge, attitude, perception, and impact of the COVID-19 pandemic.\n\nA cross-sectional online survey was conducted in Pakistan from 1 April 2020 to 1 May 2020. The study respondents were cancer patients with ages equal to or greater than 18 years. Following a request for participation, the URL for the survey was distributed on numerous channels. Other social media platforms, including WeChat, WhatsApp, Facebook, Twitter, Instagram, Messenger, and LinkedIn, were used to increase cancer patient interaction. The questionnaire comprised five different sections such as: (1) sociodemographic information, (2) knowledge, (3) attitude, (4) perception, and (5) impact of COVID-19 on cancer patients. Descriptive medical statistics such as frequency, percentage, mean, and standard deviation were used to illustrate the demographic characteristics of the study participants. To compare mean knowledge scores with selected demographic variables, independent sample t-tests and one-way analysis of variance (ANOVA) were used, which are also practical methods in epidemiological, public health and medical research. The cut-off point for statistical significance was set at a p-value of 0.05.\n\nMore than 300 cancer patients were invited, of which 208 agreed to take part. The response rate was 69.33% (208/300). Gender, marital status, and employment status had a significant association with knowledge scores. Of the total recruited participants, 96% (n = 200) (p &lt; 0.01) knew about COVID-19, and 90% were aware of general symptoms of COVID-19 disease, such as route of transmission and preventive measurements. In total, 94.5% (n = 197) (p &lt; 0.01) were willing to accept isolation if they were infected with COVID-19, and 98% (n = 204) (p &lt; 0.01) had reduced their use of public transportation. More than 90% (n = 188) (p &lt; 0.01) of cancer patients were found to be practicing preventative measures such as using a face mask, keeping social distance, and avoiding handshaking and hugging. Around 94.4% (n = 196) (p &lt; 0.01) of cancer patients had been impacted by, stopped or had changed cancer treatment during this pandemic, resulting in COVID-related anxiety and depression.\n\nThe included cancer patients exhibited a good level of COVID-19 knowledge, awareness, positive attitude, and perception. Large-scale studies and efforts are needed to raise COVID-19 awareness among less educated and high-risk populations. The present survey indicates that mass-level effective health education initiatives are required for developing countries to improve and reduce the gap between KAP and COVID-19.", "doi": "10.3390/ijerph19137926", "pmid": "35805584", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19137926"}, {"db": "pmc", "key": "PMC9265320"}], "notes": [], "created": "2022-08-17T10:43:25.603Z", "modified": "2022-08-17T10:43:25.804Z"}, {"entity": "publication", "iuid": "7dff34c69089449393aa9f3d89b939a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7dff34c69089449393aa9f3d89b939a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7dff34c69089449393aa9f3d89b939a2"}}, "title": "Case Report: Post-Partum SARS-CoV-2 Infection After the First French Uterus Transplantation.", "authors": [{"family": "Ayoubi", "given": "Jean Marc", "initials": "JM"}, {"family": "Carbonnel", "given": "Marie", "initials": "M"}, {"family": "Kvarnstr\u00f6m", "given": "Niclas", "initials": "N"}, {"family": "Revaux", "given": "Aurelie", "initials": "A"}, {"family": "Poulain", "given": "Marine", "initials": "M"}, {"family": "Vanlieferinghen", "given": "Sarah", "initials": "S"}, {"family": "Coatantiec", "given": "Yves", "initials": "Y"}, {"family": "Le Marchand", "given": "Mathilde", "initials": "M"}, {"family": "Tourne", "given": "Morgan", "initials": "M"}, {"family": "Pirtea", "given": "Paul", "initials": "P"}, {"family": "Snanoudj", "given": "Renaud", "initials": "R"}, {"family": "Le Guen", "given": "Morgan", "initials": "M"}, {"family": "Dahm-K\u00e4hler", "given": "Pernilla", "initials": "P"}, {"family": "Racowsky", "given": "Catherine", "initials": "C"}, {"family": "Br\u00e4nnstr\u00f6m", "given": "Mats", "initials": "M"}], "type": "case reports", "published": "2022-06-28", "journal": {"title": "Front Surg", "issn": "2296-875X", "volume": "9", "pages": "854225", "issn-l": null}, "abstract": "Absolute uterus factor infertility, whether congenital or acquired, renders the woman unable to carry a child. Although uterus transplantation (UTx) is being increasingly performed as a non-vital procedure to address this unfortunate condition, the immunosuppression required presents risks that are further compounded by pregnancy and during the puerperium period. These vulnerabilities require avoidance of SARS-CoV-2 infection in pregnant UTx recipients especially during the third trimester, as accumulating evidence reveals increased risks of morbidity and mortality. Here we describe a successful UTx case with delivery of a healthy child, but in which both mother and neonate developed asymptomatic SARS-CoV-2 infection seven days after RNA vaccination, on day 35 post-partum. Although the patient was successfully treated with a combination therapy comprised of two monoclonal antibodies, this case highlights the challenges associated with performing UTx in the era of Covid-19. More broadly, the risks of performing non-vital organ transplantation during a pandemic should be discussed among team members and prospective patients, weighing the risks against the benefits in improving the quality of life, which were considerable for our patient who achieved motherhood with the birth of a healthy child.", "doi": "10.3389/fsurg.2022.854225", "pmid": "35836605", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9273879"}], "notes": [], "created": "2022-08-12T08:59:34.409Z", "modified": "2022-08-12T08:59:34.435Z"}, {"entity": "publication", "iuid": "93005bbd70ac43e2aad57a176dd155c8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/93005bbd70ac43e2aad57a176dd155c8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/93005bbd70ac43e2aad57a176dd155c8"}}, "title": "Adapting teaching and learning in times of COVID-19: a comparative assessment among higher education institutions in a global health network in 2020.", "authors": [{"family": "Puradiredja", "given": "Dewi Ismajani", "initials": "DI"}, {"family": "Kintu-Sempa", "given": "Linda", "initials": "L"}, {"family": "Eyber", "given": "Carola", "initials": "C"}, {"family": "Weigel", "given": "Ralf", "initials": "R"}, {"family": "Broucker", "given": "Bruno", "initials": "B"}, {"family": "Lindkvist", "given": "Marie", "initials": "M"}, {"family": "Casamitjana", "given": "Nuria", "initials": "N"}, {"family": "Reynolds", "given": "Rodney", "initials": "R"}, {"family": "Klinkel", "given": "Hans-Friedemann", "initials": "H"}, {"family": "Matteelli", "given": "Alberto", "initials": "A"}, {"family": "Froeschl", "given": "Guenter", "initials": "G"}], "type": "journal article", "published": "2022-06-28", "journal": {"title": "BMC Med Educ", "issn": "1472-6920", "issn-l": null, "volume": "22", "issue": "1", "pages": "507"}, "abstract": "This research examines the ways in which higher education institutions (HEIs) across the tropEd Network for Education in International Health (tropEd) began to adapt their teaching and learning approaches in response to the COVID-19 pandemic in 2020. Already during this early phase of the pandemic HEIs' responses demonstrate global health approaches emphasising cooperation and communication, rather than national health driven strategies that emphasise quarantine and control. Key lessons learnt for multiple dimensions of teaching and learning in global health are thus identified, and challenges and opportunities discussed.\r\n\r\nData collection includes a cross-sectional online survey among tropEd member institutions (n = 19) in mid-2020, and a complementary set of open-ended questions generating free-text responses (n = 9). Quantitative data were analysed using descriptive statistics, textual data were analysed using a Framework Analysis approach.\r\n\r\nWhile early on in the pandemic the focus was on a quick emergency switch to online teaching formats to ensure short-term continuity, and developing the administrative and didactic competence and confidence in digital teaching, there is already recognition among HEIs of the necessity for more fundamental quality and longer-term reforms in higher education in global health. Alongside practical concerns about the limitations of digital teaching, and declines in student numbers, there is a growing awareness of opportunities in terms of inclusivity, the necessity of cross-border cooperation, and a global health approach. The extent to which the lack of physical mobility impacts HEI programmes in global health is debated.\r\n\r\nThe COVID-19 pandemic has brought about preventive measures that have had a considerable impact on various dimensions of academic teaching in global health. Going forward, international HEIs' experiences and response strategies can help generate important lessons for academic institutions across different settings worldwide.", "doi": "10.1186/s12909-022-03568-4", "pmid": "35764985", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12909-022-03568-4"}, {"db": "pmc", "key": "PMC9238047"}], "notes": [], "created": "2022-08-19T05:33:24.334Z", "modified": "2022-11-09T08:38:50.944Z"}, {"entity": "publication", "iuid": "19d3b486739b4d6f8691c56b2afa7a74", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19d3b486739b4d6f8691c56b2afa7a74.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19d3b486739b4d6f8691c56b2afa7a74"}}, "title": "Sensitization symptoms are associated with psychological and cognitive variables in COVID-19 survivors exhibiting post-COVID pain.", "authors": [{"family": "Fern\u00e1ndez-de-Las-Pe\u00f1as", "given": "C\u00e9sar", "initials": "C"}, {"family": "Par\u00e1s-Bravo", "given": "Paula", "initials": "P"}, {"family": "Ferrer-Pargada", "given": "Diego", "initials": "D", "orcid": "0000-0001-9088-5946", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a035c7a4f73a4ffd95b2f99695fdc2b0.json"}}, {"family": "Cancela-Cilleruelo", "given": "Ignacio", "initials": "I"}, {"family": "Rodr\u00edguez-Jim\u00e9nez", "given": "Jorge", "initials": "J"}, {"family": "Nijs", "given": "Jo", "initials": "J"}, {"family": "Arendt-Nielsen", "given": "Lars", "initials": "L"}, {"family": "Herrero-Montes", "given": "Manuel", "initials": "M", "orcid": "0000-0002-5732-8344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3460d36201934582b42366a9e2e736c0.json"}}], "type": "journal article", "published": "2022-06-27", "journal": {"title": "Pain Pract", "issn": "1533-2500", "issn-l": null}, "abstract": "To investigate the association between demographic, clinical, psychological, cognitive, and health-related variables and the Central Sensitization Inventory (CSI) in previously hospitalized COVID-19 survivors exhibiting \"de novo\" post-COVID pain.\n\nSeventy-seven (n = 77) COVID-19 survivors with \"de novo\" post-COVID pain completed demographic (age, height, and weight), clinical (duration and intensity of the pain), psychological (depressive/anxiety levels and sleep quality), cognitive (catastrophizing and kinesiophobia levels), and health-related quality of life variables as well as the CSI. A multivariable correlation analysis was conducted to determine the association between variables, and a stepwise multiple linear regression model was performed to identify CSI predictors.\n\nPatients were assessed a mean of 6.0 (SD 0.8) months after hospital discharge. Twenty-six (33.7%) individuals showed indications of sensitization-associated symptoms (CSI score \u226540 points). The CSI score was positively associated with pain intensity (r: 0.371), anxiety (r: 0.784), depressive (r: 0.709), catastrophizing (r: 0.620), and kinesiophobia (r: 0.359) levels (all, p < 0.001). The stepwise regression analysis revealed that 60.2% of CSI was explained by anxiety levels and pain intensity.\n\nThis study found that psychological and cognitive variables were associated with the CSI score in previously hospitalized COVID-19 survivors with \"de novo\" post-COVID pain. Anxiety levels and the intensity of pain symptoms were independently associated with CSI score suggesting a significant overlap with psychological construct. The \"de novo\" post-COVID pain association with CSI may indicate changes in the pain processing important for managing the pain.", "doi": "10.1111/papr.13146", "pmid": "35757896", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9350126"}], "notes": [], "created": "2022-08-19T05:37:46.172Z", "modified": "2022-08-19T05:37:46.280Z"}, {"entity": "publication", "iuid": "93c3450a3c054009a215c5c1b16e807e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/93c3450a3c054009a215c5c1b16e807e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/93c3450a3c054009a215c5c1b16e807e"}}, "title": "Associations between fear of COVID-19, dental anxiety, and psychological distress among Iranian adolescents.", "authors": [{"family": "Tofangchiha", "given": "Maryam", "initials": "M"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Scheerman", "given": "Janneke F M", "initials": "JFM"}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Ahonen", "given": "Hanna", "initials": "H"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Tadakamadla", "given": "Santosh Kumar", "initials": "SK"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2022-06-27", "journal": {"title": "BDJ Open", "issn": "2056-807X", "volume": "8", "issue": "1", "pages": "19", "issn-l": null}, "abstract": "The present study evaluated the association of fear of COVID-19 with dental anxiety, oral health-related quality of life (OHRQoL), and psychological distress (depression, anxiety and stress), as well as exploring the mediating role of dental anxiety in the association of fear of COVID-19 with OHRQoL and psychological distress.\n\nA cross-sectional study was conducted among adolescents in high schools of Qazvin city (Iran) from March-June 2021, recruited through a two-stage cluster sampling method. All the adolescents completed a self-administered survey assessing (i) fear of COVID-19, (ii) depression, anxiety and stress, (iii) OHRQoL, and (iv) dental anxiety. Structural equation modelling was used to evaluate all the hypothesised associations, and the model fit was estimated.\n\nA total of 2429 adolescents participated in the study. The conceptual model fitted the data well. Fear of COVID-19 had a direct effect on dental anxiety (B = 0.316; bias-corrected bootstrapping 95% CI = 0.282, 0.349), depression (B = 0.302; bias-corrected bootstrapping 95% CI = 0.259, 0.347), anxiety (B = 0.289; bias-corrected bootstrapping 95% CI = 0.246, 0.334), stress (B = 0.282; bias-corrected bootstrapping 95% CI = 0.237, 0.328), and OHRQoL (B = -0.354; bias-corrected bootstrapping 95% CI = -0.530, -0.183). Also, dental anxiety mediated the association of fear of COVID-19 with depression, anxiety stress, and OHRQoL.\n\nHigh levels of fear of COVID-19 were associated with high levels of dental anxiety and poorer OHRQoL. Moreover, fear of COVID-19 was positively associated with anxiety, depression and stress. Increased levels of dental anxiety were also associated with increased anxiety, stress, depression, and poorer OHRQoL.", "doi": "10.1038/s41405-022-00112-w", "pmid": "35760784", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41405-022-00112-w"}, {"db": "pmc", "key": "PMC9237055"}], "notes": [], "created": "2022-08-19T05:36:56.517Z", "modified": "2022-08-19T05:36:56.590Z"}, {"entity": "publication", "iuid": "e9703db559424cb8bf03af9e914f4275", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e9703db559424cb8bf03af9e914f4275.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e9703db559424cb8bf03af9e914f4275"}}, "title": "A comparative analysis of experienced uncertainties in relation to risk communication during COVID19: a four-country study.", "authors": [{"family": "Cristea", "given": "Florin", "initials": "F"}, {"family": "Weishaar", "given": "Heide", "initials": "H"}, {"family": "Geurts", "given": "Brogan", "initials": "B"}, {"family": "Delamou", "given": "Alexandre", "initials": "A"}, {"family": "Tan", "given": "Melisa Mei Jin", "initials": "MMJ"}, {"family": "Legido-Quigley", "given": "Helena", "initials": "H"}, {"family": "Aminu", "given": "Kafayat", "initials": "K"}, {"family": "Mari-S\u00e1ez", "given": "Almudena", "initials": "A"}, {"family": "Rocha", "given": "Carlos", "initials": "C"}, {"family": "Camara", "given": "Bienvenu", "initials": "B"}, {"family": "Barry", "given": "Lansana", "initials": "L"}, {"family": "Thea", "given": "Paul", "initials": "P"}, {"family": "Boucsein", "given": "Johannes", "initials": "J"}, {"family": "Bahr", "given": "Thurid", "initials": "T"}, {"family": "Al-Awlaqi", "given": "Sameh", "initials": "S"}, {"family": "Pozo-Martin", "given": "Francisco", "initials": "F"}, {"family": "Boklage", "given": "Evgeniya", "initials": "E"}, {"family": "Jegede", "given": "Ayodele Samuel", "initials": "AS"}, {"family": "Bcheraoui", "given": "Charbel El", "initials": "CE"}], "type": "journal article", "published": "2022-06-27", "journal": {"title": "Global Health", "issn": "1744-8603", "volume": "18", "issue": "1", "pages": "66", "issn-l": "1744-8603"}, "abstract": "During outbreaks, uncertainties experienced by affected communities can influence their compliance to government guidance on public health. Communicators and authorities are, hence, encouraged to acknowledge and address such uncertainties. However, in the midst of public health crises, it can become difficult to define and identify uncertainties that are most relevant to address. We analyzed data on COVID-19-related uncertainties from four socio-economic contexts to explore how uncertainties can influence people's perception of, and response to Risk Communication and Community Engagement (RCCE) strategies.\n\nThis qualitative study, which adopts an interpretative approach, is based on data from a documentary review, key informant interviews (KII), and focus group discussions (FGD) with members of the general public and people with barriers to information from Germany, Guinea, Nigeria, and Singapore. Transcripts from the KII and FGD were coded and analyzed thematically. We interviewed a total of 155 KIs and conducted 73 FGD. Our analysis uncovered a divergence between uncertainties deemed relevant by stakeholders involved in policy making and uncertainties that people reportedly had to navigate in their everyday lives and which they considered relevant during the pandemic. We identified four types of uncertainties that seemed to have influenced people's assessment of the disease risk and their trust in the pandemic control strategies including RCCE efforts: epidemiological uncertainties (related to the nature and severity of the virus), information uncertainties (related to access to reliable information), social uncertainties (related to social behavior in times of heightened risk), and economic uncertainties (related to financial insecurities).\n\nWe suggest that in future outbreaks, communicators and policy makers could improve the way in which affected communities assess their risk, and increase the trust of these communities in response efforts by addressing non-epidemiological uncertainties in RCCE strategies.", "doi": "10.1186/s12992-022-00857-x", "pmid": "35761365", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12992-022-00857-x"}, {"db": "pmc", "key": "PMC9235152"}], "notes": [], "created": "2022-08-19T05:35:54.224Z", "modified": "2022-08-19T05:35:54.240Z"}, {"entity": "publication", "iuid": "5913952e0d3b4443bcace68980cf43ed", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5913952e0d3b4443bcace68980cf43ed.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5913952e0d3b4443bcace68980cf43ed"}}, "title": "Socio-Ecological Factors and Well-Being among Self-Employed in Europe during the COVID-19 Pandemic.", "authors": [{"family": "Hansson", "given": "Josefine", "initials": "J", "orcid": "0000-0001-6385-1556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04f28c63354f4e11b27b8abdab4c58b7.json"}}, {"family": "Nordenmark", "given": "Mikael", "initials": "M"}, {"family": "Tjulin", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Landstad", "given": "Bodil J", "initials": "BJ"}, {"family": "Vinberg", "given": "Stig", "initials": "S", "orcid": "0000-0002-5935-5688", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c63c4ca58d242d18741dba0b0af5afb.json"}}], "type": "journal article", "published": "2022-06-26", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "13", "issn-l": null}, "abstract": "The self-employed are at increased risk of negative well-being outcomes when facing adversity such as the COVID-19 pandemic. Studies that examine socio-ecological factors that may protect their well-being are warranted.\n\nData were drawn from a cross-sectional survey of European self-employed people (n = 1665). The WHO-5 Well-being Index was used to examine the impact on well-being of factors at four socio-ecological levels. Independent sample t-tests, Pearson correlations and linear regression were applied to analyse differences between groups of self-employed and interactions between variables using SPSS.\n\nWell-being and the socio-ecological factors of resilience, social support, useful work and finding the rules clear were positively correlated with well-being. For self-employed who reported that it was challenging to run their business during the pandemic, social support and finding rules clear were of significantly greater importance to their well-being.\n\nThe findings highlight that the socio-ecological factors of resilience, social support, doing useful work and finding the rules clear affect well-being. The results also indicate that it is vital to consider factors at multiple socio-ecological levels to improve the well-being of the self-employed during adversity.", "doi": "10.3390/ijerph19137840", "pmid": "35805499", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19137840"}, {"db": "pmc", "key": "PMC9266291"}], "notes": [], "created": "2022-08-17T10:43:44.466Z", "modified": "2022-08-17T10:43:53.138Z"}, {"entity": "publication", "iuid": "375d0e6589464233885e6d24fbf73de0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/375d0e6589464233885e6d24fbf73de0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/375d0e6589464233885e6d24fbf73de0"}}, "title": "Epigenetic rewiring of pathways related to odour perception in immune cells exposed to SARS-CoV-2 in vivo and in vitro.", "authors": [{"family": "Huoman", "given": "Johanna", "initials": "J", "orcid": "0000-0003-2509-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83ac07f7b8c64d0090490070a3893006.json"}}, {"family": "Sayyab", "given": "Shumaila", "initials": "S", "orcid": "0000-0002-6048-775X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80e824deb3c54d2089f6615099188de1.json"}}, {"family": "Apostolou", "given": "Eirini", "initials": "E"}, {"family": "Karlsson", "given": "Lovisa", "initials": "L", "orcid": "0000-0003-2704-1788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2776385bc7d6419cb4378f33422425a0.json"}}, {"family": "Porcile", "given": "Lucas", "initials": "L", "orcid": "0000-0002-9164-4113", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4fe6ded8a7f74d64b9f1082da69f19ff.json"}}, {"family": "Rizwan", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-1725-8337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8aa9753dd6ae4622915f731fd54edf54.json"}}, {"family": "Sharma", "given": "Sumit", "initials": "S", "orcid": "0000-0003-0299-1285", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b6ce9aac5824a6f8d034a62e95f642f.json"}}, {"family": "Das", "given": "Jyotirmoy", "initials": "J", "orcid": "0000-0002-5649-4658", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/883ec5a66e47458fa303f9df2572f669.json"}}, {"family": "Ros\u00e9n", "given": "Anders", "initials": "A", "orcid": "0000-0001-5082-6423", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49ec1de9d88d4124a265b477662f0d0a.json"}}, {"family": "Lerm", "given": "Maria", "initials": "M", "orcid": "0000-0002-5092-9892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a326e1fb7efa4c4f8f59e7572f6b83bc.json"}}], "type": "journal article", "published": "2022-06-26", "journal": {"title": "Epigenetics", "issn": "1559-2308", "pages": "1-17", "issn-l": null}, "abstract": "A majority of SARS-CoV-2 recoverees develop only mild-to-moderate symptoms, while some remain completely asymptomatic. Although viruses, including SARS-CoV-2, may evade host immune responses by epigenetic mechanisms including DNA methylation, little is known about whether these modifications are important in defence against and healthy recovery from COVID-19 in the host. To this end, epigenome-wide DNA methylation patterns from COVID-19 convalescents were compared to uninfected controls from before and after the pandemic. Peripheral blood mononuclear cell (PBMC) DNA was extracted from uninfected controls, COVID-19 convalescents, and symptom-free individuals with SARS-CoV-2-specific T cell-responses, as well as from PBMCs stimulated in vitro with SARS-CoV-2. Subsequently, the Illumina MethylationEPIC 850K array was performed, and statistical/bioinformatic analyses comprised differential DNA methylation, pathway over-representation, and module identification analyses. Differential DNA methylation patterns distinguished COVID-19 convalescents from uninfected controls, with similar results in an experimental SARS-CoV-2 infection model. A SARS-CoV-2-induced module was identified in vivo, comprising 66 genes of which six (TP53, INS, HSPA4, SP1, ESR1, and FAS) were present in corresponding in vitro analyses. Over-representation analyses revealed involvement in Wnt, muscarinic acetylcholine receptor signalling, and gonadotropin-releasing hormone receptor pathways. Furthermore, numerous differentially methylated and network genes from both settings interacted with the SARS-CoV-2 interactome. Altered DNA methylation patterns of COVID-19 convalescents suggest recovery from mild-to-moderate SARS-CoV-2 infection leaves longstanding epigenetic traces. Both in vitro and in vivo exposure caused epigenetic modulation of pathways thataffect odour perception. Future studies should determine whether this reflects host-induced protective antiviral defense or targeted viral hijacking to evade host defence.", "doi": "10.1080/15592294.2022.2089471", "pmid": "35758003", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-19T05:37:15.000Z", "modified": "2022-08-19T05:37:15.278Z"}, {"entity": "publication", "iuid": "edd352e915f645408a416238fae795a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/edd352e915f645408a416238fae795a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/edd352e915f645408a416238fae795a1"}}, "title": "Seroprevalence of SARS-CoV-2 in Sweden, April 26 to May 9, 2021.", "authors": [{"family": "Beser", "given": "Jessica", "initials": "J"}, {"family": "Galanis", "given": "Ilias", "initials": "I"}, {"family": "Enkirch", "given": "Theresa", "initials": "T"}, {"family": "K\u00fchlmann Berenzon", "given": "Sharon", "initials": "S"}, {"family": "van Straten", "given": "Edward", "initials": "E"}, {"family": "Duracz", "given": "Jan", "initials": "J"}, {"family": "Rapp", "given": "Marie", "initials": "M"}, {"family": "Zakikhany", "given": "Katherina", "initials": "K"}, {"family": "Mansj\u00f6", "given": "Mikael", "initials": "M"}, {"family": "Wigren Bystr\u00f6m", "given": "Julia", "initials": "J"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Groenheit", "given": "Ramona", "initials": "R"}, {"family": "Tegmark Wisell", "given": "Karin", "initials": "K"}, {"family": "Br\u00e5ve", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2022-06-25", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "10816", "issn-l": "2045-2322"}, "abstract": "A national point seroprevalence study of SARS-CoV-2 was conducted in Sweden in April-May 2021. In total, 2860 individuals 3 to 90 years old from a probability-based web panel were included. Results showed that an estimated 32.6% of the population in Sweden had detectable levels of antibodies, and among non-vaccinated 20.1% had detectable levels of antibodies. We tested for differences in seroprevalence between age groups and by sex and estimated seroprevalence among previously infected participants by time since reporting.", "doi": "10.1038/s41598-022-15183-w", "pmid": "35752708", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-15183-w"}, {"db": "pmc", "key": "PMC9233662"}], "notes": [], "created": "2022-08-19T05:40:11.690Z", "modified": "2022-08-19T05:40:11.696Z"}, {"entity": "publication", "iuid": "49204daeaf184d10a9cef9d6c9613fc1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49204daeaf184d10a9cef9d6c9613fc1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49204daeaf184d10a9cef9d6c9613fc1"}}, "title": "Quality of life among health care workers with and without prior COVID-19 infection in Bangladesh.", "authors": [{"family": "Rahman", "given": "Mahfil Ara", "initials": "MA"}, {"family": "Sagar", "given": "Soumik Kha", "initials": "SK"}, {"family": "Dalal", "given": "Koustuv", "initials": "K", "orcid": "0000-0001-7393-796X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab5e44a17b7545988cb46cdf5b1f3e4e.json"}}, {"family": "Barsha", "given": "Sabrina Yesmin", "initials": "SY"}, {"family": "Ara", "given": "Tasnim", "initials": "T"}, {"family": "Khan", "given": "Md Abdullah Saeed", "initials": "MAS"}, {"family": "Saha", "given": "Shuvajit", "initials": "S"}, {"family": "Sarmin", "given": "Tanjina", "initials": "T"}, {"family": "Hossian", "given": "Mosharop", "initials": "M"}, {"family": "Nabi", "given": "Mohammad Hayatun", "initials": "MH"}, {"family": "Rahman", "given": "Mohammad Lutfor", "initials": "ML"}, {"family": "Hawlader", "given": "Mohammad Delwer Hossain", "initials": "MDH"}], "type": "journal article", "published": "2022-06-25", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "volume": "22", "issue": "1", "pages": "823", "issn-l": null}, "abstract": "Health care workers have been facing difficulties in coping with the COVID-19 infection from the beginning. The study aimed to compare Quality of Life (QOL) among health care workers (HCWs) with and without prior COVID-19 disease.\n\nThis study was conducted from July 2020 to January 2021 among 444 HCWs. We randomly interviewed 3244 participants for our earlier nationwide survey from a list of COVID-19 positive cases after their recovery, and we found 222 HCWs among the respondents. We randomly chose 222 HCWs unaffected by COVID as a comparison group from our selected hospitals. We measured QOL using World Health Organization's WHOQOL-BREF tool. Physical, psychological, environmental, and social ties were the four areas assessed on a 5-point Likert scale where a higher score suggests better QOL. Due to pandemic restrictions, we used telephonic interviews for data collection.\n\nA higher QOL score was observed in HCWs with prior COVID-19 infection in all four domains than HCWs without previous COVID-19 conditions. Comorbidity was negatively associated with QOL scores of the physical (p = 0.001) and (p < 0.001) and psychological (p = 0.05, and (p < 0.05) domains for non-COVID and COVID-affected groups, respectively. Current smoking was significantly associated with lower psychological (p = 0.019) and environmental (p = 0.007) QOL scores among HCWs with prior COVID-19 infection. Hospitalization history due to COVID infection was a contributing factor for lower physical QOL scores (p = 0.048). Environmental (p = 0.016) QOL scores were significantly associated with the monthly income in the prior COVID-19 infection group, and physical scores were significantly associated (p = 0.05) with a monthly income in the non-COVID group.\n\nGovernmental and non-governmental stakeholders should focus on potentially modifiable factors to improve health care workers' quality of life.", "doi": "10.1186/s12913-022-08174-0", "pmid": "35752784", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-022-08174-0"}, {"db": "pmc", "key": "PMC9233781"}], "notes": [], "created": "2022-08-19T05:39:51.105Z", "modified": "2022-08-19T05:39:51.148Z"}, {"entity": "publication", "iuid": "24907a395ed8437eb499edb4f4697bd8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24907a395ed8437eb499edb4f4697bd8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24907a395ed8437eb499edb4f4697bd8"}}, "title": "Have Health Inequalities Increased during the COVID-19 Pandemic? Evidence from Recent Years for Older European Union Citizens.", "authors": [{"family": "Gonz\u00e1lez Rodr\u00edguez", "given": "Irene", "initials": "I"}, {"family": "Pascual S\u00e1ez", "given": "Marta", "initials": "M"}, {"family": "Cantarero Prieto", "given": "David", "initials": "D"}], "type": "journal article", "published": "2022-06-25", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "13", "issn-l": null}, "abstract": "Reducing inequality is one of the current challenges that most societies are facing. Our aim was to analyze the evolution of inequalities in self-assessed health among older Europeans in a time period spanning the 2008 economic crisis and the COVID-19 health crisis. We used data from Waves 2, 4 and 8 of the Survey of Health, Ageing and Retirement in Europe. We used inequality indices that accept ordinal variables. Our empirical results suggest that average inequality declines over time. Gender significantly influences the results. Some of the countries with the highest level of inequality are Denmark and Sweden, and some with the lowest are Estonia and the Netherlands. Our results may be of interest for the development of public policies to reduce inequalities. Special attention should be paid to vulnerable groups, such as the elderly.", "doi": "10.3390/ijerph19137812", "pmid": "35805469", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19137812"}, {"db": "pmc", "key": "PMC9265733"}], "notes": [], "created": "2022-08-17T10:44:08.425Z", "modified": "2022-08-17T10:44:08.442Z"}, {"entity": "publication", "iuid": "1ce2276235264619893a58a1534fe868", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ce2276235264619893a58a1534fe868.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ce2276235264619893a58a1534fe868"}}, "title": "Children with psoriasis and COVID-19: factors associated with an unfavourable COVID-19 course, and the impact of infection on disease progression (Chi-PsoCov registry).", "authors": [{"family": "Zitouni", "given": "J", "initials": "J"}, {"family": "Bursztejn", "given": "A-C", "initials": "AC"}, {"family": "Belloni Fortina", "given": "A", "initials": "A", "orcid": "0000-0001-5791-0775", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f10eaae7700c4eee85c4bbd8947f5d21.json"}}, {"family": "Beauchet", "given": "A", "initials": "A"}, {"family": "Di Lernia", "given": "V", "initials": "V"}, {"family": "Lesiak", "given": "A", "initials": "A"}, {"family": "Thomas", "given": "J", "initials": "J"}, {"family": "Topkarci", "given": "Z", "initials": "Z"}, {"family": "Murashkin", "given": "N", "initials": "N", "orcid": "0000-0003-2252-8570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/780f117056524c3686f523771c79c35e.json"}}, {"family": "Brzezinski", "given": "P", "initials": "P", "orcid": "0000-0001-6817-606X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c59b93962ec045b39373303e1bdbd518.json"}}, {"family": "Torres", "given": "T", "initials": "T", "orcid": "0000-0003-0404-0870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54a6d84c2e9045eab3f506c4860aaeb3.json"}}, {"family": "Chiriac", "given": "A", "initials": "A", "orcid": "0000-0002-0989-4931", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a50fa61a4dc4d728e42c620fc06e8d0.json"}}, {"family": "Luca", "given": "C", "initials": "C"}, {"family": "McPherson", "given": "T", "initials": "T"}, {"family": "Akinde", "given": "M", "initials": "M"}, {"family": "Maruani", "given": "A", "initials": "A"}, {"family": "Epishev", "given": "R", "initials": "R"}, {"family": "Vidaurri de la Cruz", "given": "H", "initials": "H"}, {"family": "Luna", "given": "P C", "initials": "PC"}, {"family": "Amy de la Bret\u00eaque", "given": "M", "initials": "M"}, {"family": "Lasek", "given": "A", "initials": "A", "orcid": "0000-0002-4105-4027", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68e435ca02b345d6902a366c4e8e1879.json"}}, {"family": "Bourrat", "given": "E", "initials": "E"}, {"family": "Bachelerie", "given": "M", "initials": "M"}, {"family": "Mallet", "given": "S", "initials": "S"}, {"family": "Steff", "given": "M", "initials": "M"}, {"family": "Bellissen", "given": "A", "initials": "A"}, {"family": "Neri", "given": "I", "initials": "I"}, {"family": "Zafiriou", "given": "E", "initials": "E", "orcid": "0000-0002-6594-7292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/99d5a40411774f848f72fd5df470583c.json"}}, {"family": "van den Reek", "given": "J M P A", "initials": "JMPA"}, {"family": "Sonkoly", "given": "E", "initials": "E", "orcid": "0000-0002-4909-5413", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc17777e8b4e43ef918ddf68d3dce068.json"}}, {"family": "Mahil", "given": "S K", "initials": "SK"}, {"family": "Smith", "given": "C H", "initials": "CH", "orcid": "0000-0001-9918-1144", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4d49fa2c6a44215b42d5ee1e2e81190.json"}}, {"family": "Flohr", "given": "C", "initials": "C", "orcid": "0000-0003-4884-6286", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13d37914df3244d5ae62b9ece4ce2602.json"}}, {"family": "Bachelez", "given": "H", "initials": "H"}, {"family": "Mah\u00e9", "given": "E", "initials": "E", "orcid": "0000-0001-5780-1827", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f2012056d0e14e66a2d7f97812a768a5.json"}}, {"family": "Groupe de Recherche sur le Psoriasis (GrPso) of the Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie, the Groupe de recherche de la Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie P\u00e9diatrique (GR SFDP), the PsoProtect study group, the British Society of Paediatric Dermatology (BPSD), and the Societ\u00e0 Italiana di Dermatologia Pediatrica (S.I.Der.P.)", "given": "", "initials": ""}], "type": "journal article", "published": "2022-06-24", "journal": {"title": "J Eur Acad Dermatol Venereol", "issn": "1468-3083", "issn-l": null}, "abstract": "The COVID-19 pandemic has raised questions regarding the management of chronic skin diseases, especially in patients on systemic treatments. Data concerning the use of biologics in adults with psoriasis are reassuring, but data specific to children are missing. Moreover, COVID-19 could impact the course of psoriasis in children.\n\nThe aim of this study was therefore to assess the impact of COVID-19 on the psoriasis of children, and the severity of the infection in relation to systemic treatments.\n\nWe set up an international registry of paediatric psoriasis patients. Children were included if they were under 18 years of age, had a history of psoriasis, or developed it within 1 month of COVID-19 and had COVID-19 with or without symptoms.\n\nOne hundred and twenty episodes of COVID-19 in 117 children (mean age: 12.4 years) were reported. The main clinical form of psoriasis was plaque type (69.4%). Most children were without systemic treatment (54.2%); 33 (28.3%) were on biologic therapies, and 24 (20%) on non-biologic systemic drugs. COVID-19 was confirmed in 106 children (88.3%) and 3 children had two COVID-19 infections each. COVID-19 was symptomatic for 75 children (62.5%) with a mean duration of 6.5 days, significantly longer for children on non-biologic systemic treatments (P = 0.02) and without systemic treatment (P = 0.006) when compared with children on biologics. The six children who required hospitalization were more frequently under non-biologic systemic treatment when compared with the other children (P = 0.01), and particularly under methotrexate (P = 0.03). After COVID-19, the psoriasis worsened in 17 cases (15.2%). Nine children (8%) developed a psoriasis in the month following COVID-19, mainly a guttate form (P = 0.01).\n\nBiologics appear to be safe with no increased risk of severe form of COVID-19 in children with psoriasis. COVID-19 was responsible for the development of psoriasis or the worsening of a known psoriasis for some children.", "doi": "10.1111/jdv.18361", "pmid": "35748102", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9349726"}], "notes": [], "created": "2022-08-19T05:40:29.879Z", "modified": "2022-08-19T05:40:49.724Z"}, {"entity": "publication", "iuid": "ebacd66fb4254d659f20819fbec4c072", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ebacd66fb4254d659f20819fbec4c072.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ebacd66fb4254d659f20819fbec4c072"}}, "title": "Susceptibility of Patients with Asthma to Poor Outcome of COVID-19.", "authors": [{"family": "Persson", "given": "Carl", "initials": "C"}], "type": "journal article", "published": "2022-06-23", "journal": {"title": "Am J Respir Crit Care Med", "issn": "1535-4970", "issn-l": "1073-449X"}, "abstract": null, "doi": "10.1164/rccm.202205-0978LE", "pmid": "35737585", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-19T05:50:50.241Z", "modified": "2022-08-19T05:50:50.255Z"}, {"entity": "publication", "iuid": "649df7de666440e992c1c66547d697d6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/649df7de666440e992c1c66547d697d6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/649df7de666440e992c1c66547d697d6"}}, "title": "Long-COVID in children and adolescents: a systematic review and meta-analyses.", "authors": [{"family": "Lopez-Leon", "given": "Sandra", "initials": "S", "orcid": "0000-0001-7504-3441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/311cfec51fe9447283ee5c3a4ca0a3cd.json"}}, {"family": "Wegman-Ostrosky", "given": "Talia", "initials": "T", "orcid": "0000-0002-3207-6697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ebacfc4db6e4a04aab46b7172d828f2.json"}}, {"family": "Ayuzo Del Valle", "given": "Norma Cipatli", "initials": "NC", "orcid": "0000-0002-8110-3532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/222db71f009442798ef9b2ac782bb312.json"}}, {"family": "Perelman", "given": "Carol", "initials": "C", "orcid": "0000-0002-0111-1154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb4874d2c45c4d698c57f5e3705d306d.json"}}, {"family": "Sepulveda", "given": "Rosalinda", "initials": "R", "orcid": "0000-0003-1146-9552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e217c9ab8c24eeca127ffb1dd89b843.json"}}, {"family": "Rebolledo", "given": "Paulina A", "initials": "PA", "orcid": "0000-0002-9808-063X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bbee43f79e147b39028119e0b573c72.json"}}, {"family": "Cuapio", "given": "Angelica", "initials": "A", "orcid": "0000-0002-9451-1914", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f4915fdfa7d460f9b705b56b0fc1c4a.json"}}, {"family": "Villapol", "given": "Sonia", "initials": "S", "orcid": "0000-0002-6174-4113", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04eb73dcc16546b0b153a41bcba039af.json"}}], "type": "journal article", "published": "2022-06-23", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "9950", "issn-l": "2045-2322"}, "abstract": "The objective of this systematic review and meta-analyses is to estimate the prevalence of long-COVID in children and adolescents and to present the full spectrum of symptoms present after acute COVID-19. We have used PubMed and Embase to identify observational studies published before February 10th, 2022 that included a minimum of 30 patients with ages ranging from 0 to 18 years that met the National Institute for Healthcare Excellence (NICE) definition of long-COVID, which consists of both ongoing (4 to 12 weeks) and post-COVID-19 (\u2265 12 weeks) symptoms. Random-effects meta-analyses were performed using the MetaXL software to estimate the pooled prevalence with a 95% confidence interval (CI). Heterogeneity was assessed using I2 statistics. The Preferred Reporting Items for Systematic Reviewers and Meta-analysis (PRISMA) reporting guideline was followed (registration PROSPERO CRD42021275408). The literature search yielded 8373 publications, of which 21 studies met the inclusion criteria, and a total of 80,071 children and adolescents were included. The prevalence of long-COVID was 25.24%, and the most prevalent clinical manifestations were mood symptoms (16.50%), fatigue (9.66%), and sleep disorders (8.42%). Children infected by SARS-CoV-2 had a higher risk of persistent dyspnea, anosmia/ageusia, and/or fever compared to controls. Limitations of the studies analyzed include lack of standardized definitions, recall, selection, misclassification, nonresponse and/or loss of follow-up, and a high level of heterogeneity.", "doi": "10.1038/s41598-022-13495-5", "pmid": "35739136", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-13495-5"}, {"db": "pmc", "key": "PMC9226045"}], "notes": [], "created": "2022-08-19T05:50:23.537Z", "modified": "2022-08-19T05:50:30.738Z"}, {"entity": "publication", "iuid": "bf54121e5e9c41c7922320e941b41e55", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf54121e5e9c41c7922320e941b41e55.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf54121e5e9c41c7922320e941b41e55"}}, "title": "English dictionaries, gold and silver standard corpora for biomedical natural language processing related to SARS-CoV-2 and COVID-19", "authors": [{"family": "Kazemi Rashed", "given": "S", "initials": "S"}, {"family": "Ahmed", "given": "R", "initials": "R"}, {"family": "Frid", "given": "J", "initials": "J"}, {"family": "Aits", "given": "S", "initials": "S"}], "type": null, "published": "2022-06-23", "journal": {"title": "Arxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "https://doi.org/10.48550/arXiv.2003.09865", "pmid": null, "labels": {"Category: Health": null, "Type: Preprint": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "SRA", "key": "https://github.com/Aitslab/corona", "description": "https://github.com/Aitslab/corona"}, {"db": "URL", "key": "https://doi.org/10.5281/zenodo.6642275", "description": "https://doi.org/10.5281/zenodo.6642275"}], "notes": [], "created": "2022-06-23T06:26:18.948Z", "modified": "2023-02-22T08:06:48.608Z"}, {"entity": "publication", "iuid": "07b7e771e6d74fff82e04ed1d6be5533", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07b7e771e6d74fff82e04ed1d6be5533.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07b7e771e6d74fff82e04ed1d6be5533"}}, "title": "COVID-19 vaccine-induced adverse events predict immunogenicity among recipients of allogeneic haematopoietic stem cell transplantation.", "authors": [{"family": "Wiktorin", "given": "Hanna Grauers", "initials": "HG"}, {"family": "Einarsdottir", "given": "Sigrun", "initials": "S"}, {"family": "T\u00f6rnell", "given": "Andreas", "initials": "A"}, {"family": "Arabpour", "given": "Mohammad", "initials": "M"}, {"family": "Issdisai", "given": "Nuttida", "initials": "N"}, {"family": "Waldenstr\u00f6m", "given": "Jesper", "initials": "J"}, {"family": "Ringlander", "given": "Johan", "initials": "J"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K"}, {"family": "Martner", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-06-23", "journal": {"title": "Haematologica", "issn": "1592-8721", "issn-l": null}, "abstract": "Not available.", "doi": "10.3324/haematol.2022.280813", "pmid": "35734932", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-19T05:51:10.760Z", "modified": "2022-08-19T05:51:29.781Z"}, {"entity": "publication", "iuid": "4146548be296461e80f0b92a21d97c59", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4146548be296461e80f0b92a21d97c59.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4146548be296461e80f0b92a21d97c59"}}, "title": "Neurological Involvement in COVID-19 Among Non-Hospitalized Adolescents and Young Adults.", "authors": [{"family": "Havdal", "given": "Lise Beier", "initials": "LB"}, {"family": "Berven", "given": "Lise Lund", "initials": "LL"}, {"family": "Selvakumar", "given": "Joel", "initials": "J"}, {"family": "Stiansen-Sonerud", "given": "Tonje", "initials": "T"}, {"family": "Leegaard", "given": "Truls Michael", "initials": "TM"}, {"family": "Tjade", "given": "Trygve", "initials": "T"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Wyller", "given": "Vegard Bruun Bratholm", "initials": "VBB"}], "type": "journal article", "published": "2022-06-22", "journal": {"title": "Front Neurol", "issn": "1664-2295", "volume": "13", "pages": "915712", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) is prevalent among young people, and neurological involvement has been reported. We investigated neurological symptoms, cognitive test results, and biomarkers of brain injury, as well as associations between these variables in non-hospitalized adolescents and young adults with COVID-19.\n\nThis study reports baseline findings from an ongoing observational cohort study of COVID-19 cases and non-COVID controls aged 12-25 years (Clinical Trials ID: NCT04686734). Symptoms were charted using a standardized questionnaire. Cognitive performance was evaluated by applying tests of working memory, verbal learning, delayed recall, and recognition. The brain injury biomarkers, neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAp), were assayed in serum samples using ultrasensitive immunoassays.\n\nA total of 405 COVID-19 cases and 111 non-COVID cases were prospectively included. Serum Nfl and GFAp concentrations were significantly elevated in COVID-19 cases as compared with non-COVID controls (p = 0.050 and p = 0.014, respectively). The COVID-19 cases reported more fatigue (p < 0.001) and post-exertional malaise (PEM) (p = 0.001) compared to non-COVID-19 controls. Cognitive test performance and clinical neurological examination did not differ across the two groups. Within the COVID-19 group, there were no associations between symptoms, cognitive test results, and NfL or GFAp levels. However, fatigue and PEM were strongly associated with older age and female sex.\n\nNon-hospitalized adolescents and young adults with COVID-19 reported more fatigue and PEM and had slightly elevated levels of brain injury markers, but showed normal cognitive performance. No associations were found between symptoms, brain injury markers, and cognitive test results, but fatigue and PEM were strongly related to female sex and older age.", "doi": "10.3389/fneur.2022.915712", "pmid": "35812102", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9257204"}], "notes": [], "created": "2022-08-17T10:39:11.368Z", "modified": "2022-08-17T10:39:11.383Z"}, {"entity": "publication", "iuid": "3b9514af60f34b5a864db3b1ab5544eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b9514af60f34b5a864db3b1ab5544eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b9514af60f34b5a864db3b1ab5544eb"}}, "title": "Agile software development one year into the COVID-19 pandemic.", "authors": [{"family": "\u00c5gren", "given": "Pernilla", "initials": "P"}, {"family": "Knoph", "given": "Eli", "initials": "E"}, {"family": "Berntsson Svensson", "given": "Richard", "initials": "R"}], "type": "journal article", "published": "2022-06-22", "journal": {"title": "Empir Softw Eng", "issn": "1573-7616", "issn-l": null, "volume": "27", "issue": "6", "pages": "121"}, "abstract": "As a result of the COVID-19 pandemic, many agile practitioners had to transition into a remote work environment. Despite remote work not being a new concept for agile software practitioners, the forced or recommended nature of remote work is new. This study investigates how the involuntary shift to remote work and how social restrictions imposed by the COVID-19 pandemic have affected agile software development (ASD), and how agile practitioners have been affected in terms of ways of working. An explanatory sequential mixed methods study was performed. Data were collected one year into the COVID-19 pandemic through a questionnaire with 96 respondents and in-depth semi-structured interviews with seven practitioners from seven different companies. Data were analyzed through Bayesian analysis and thematic analysis. The results show, in general, that the aspects of ASD that have been the most affected is communication and social interactions, while technical work aspects have not experienced the same changes. Moreover, feeling forced to work remotely has a significant impact on different aspects of ASD, e.g., productivity and communication, and industry practitioners' employment of agile development and ways of working have primarily been affected by the lack of social interaction and the shift to digital communication. The results also suggest that there may be a group maturing debt when teams do go back into office, as digital communication and the lack of psychological safety stand in the way for practitioners' ability to have sensitive discussions and progress as a team in a remote setting.", "doi": "10.1007/s10664-022-10176-9", "pmid": "35757145", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10176"}, {"db": "pmc", "key": "PMC9214195"}], "notes": [], "created": "2022-08-19T05:38:34.428Z", "modified": "2022-11-09T08:40:12.194Z"}, {"entity": "publication", "iuid": "9a83041a95b949c2a1e8748cf44d5cd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9a83041a95b949c2a1e8748cf44d5cd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9a83041a95b949c2a1e8748cf44d5cd0"}}, "title": "S100A4 exerts robust mucosal adjuvant activity for co-administered antigens in mice.", "authors": [{"family": "Sen Chaudhuri", "given": "Arka", "initials": "A"}, {"family": "Yeh", "given": "Yu-Wen", "initials": "YW"}, {"family": "Zewdie", "given": "Olifan", "initials": "O"}, {"family": "Li", "given": "Nga Shan", "initials": "NS"}, {"family": "Sun", "given": "Jia-Bin", "initials": "JB"}, {"family": "Jin", "given": "Tao", "initials": "T"}, {"family": "Wei", "given": "Bin", "initials": "B"}, {"family": "Holmgren", "given": "Jan", "initials": "J"}, {"family": "Xiang", "given": "Zou", "initials": "Z", "orcid": "0000-0003-3925-0296", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61c1684aa00746dfae1bad8c84111033.json"}}], "type": "journal article", "published": "2022-06-21", "journal": {"title": "Mucosal Immunol", "issn": "1935-3456", "issn-l": null}, "abstract": "The lack of clinically applicable mucosal adjuvants is a major hurdle in designing effective mucosal vaccines. We hereby report that the calcium-binding protein S100A4, which regulates a wide range of biological functions, is a potent mucosal adjuvant in mice for co-administered antigens, including the SARS-CoV-2 spike protein, with comparable or even superior efficacy as cholera toxin but without causing any adverse reactions. Intranasal immunization with recombinant S100A4 elicited antigen-specific antibody and pulmonary cytotoxic T cell responses, and these responses were remarkably sustained for longer than 6 months. As a self-protein, S100A4 did not stimulate antibody responses against itself, a quality desired of adjuvants. S100A4 prolonged nasal residence of intranasally delivered antigens and promoted migration of antigen-presenting cells. S100A4-pulsed dendritic cells potently activated cognate T cells. Furthermore, S100A4 induced strong germinal center responses revealed by both microscopy and mass spectrometry, a novel label-free technique for measuring germinal center activity. Importantly, S100A4 did not induce olfactory bulb inflammation after nasal delivery, which is often a safety concern for nasal vaccination. In conclusion, S100A4 may be a promising adjuvant in formulating mucosal vaccines, including vaccines against pathogens that infect via the respiratory tract, such as SARS-CoV-2.", "doi": "10.1038/s41385-022-00535-6", "pmid": "35729204", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41385-022-00535-6"}, {"db": "pmc", "key": "PMC9212208"}], "notes": [], "created": "2022-08-17T13:06:09.232Z", "modified": "2022-08-17T13:06:09.309Z"}, {"entity": "publication", "iuid": "be0427dd3a9f4cb0b82fdfd48240a897", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be0427dd3a9f4cb0b82fdfd48240a897.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be0427dd3a9f4cb0b82fdfd48240a897"}}, "title": "Incidence of acute myocardial injury and its association with left and right ventricular systolic dysfunction in critically ill COVID-19 patients.", "authors": [{"family": "Jansson", "given": "Saga", "initials": "S"}, {"family": "Blixt", "given": "Patrik Johansson", "initials": "PJ"}, {"family": "Didriksson", "given": "Helen", "initials": "H"}, {"family": "Jonsson", "given": "Carina", "initials": "C"}, {"family": "Andersson", "given": "Henrik", "initials": "H"}, {"family": "Hedstr\u00f6m", "given": "Cassandra", "initials": "C"}, {"family": "Engvall", "given": "Jan", "initials": "J"}, {"family": "Aneq", "given": "Meriam \u00c5strom", "initials": "M\u00c5"}, {"family": "Chew", "given": "Michelle S", "initials": "MS", "orcid": "0000-0003-2888-4111", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c68391bb66e94be1ac0a14d69430666e.json"}}], "type": "journal article", "published": "2022-06-21", "journal": {"title": "Ann Intensive Care", "issn": "2110-5820", "volume": "12", "issue": "1", "pages": "56", "issn-l": null}, "abstract": "Previous studies have found an increase in cardiac troponins (cTns) and echocardiographic abnormalities in patients with COVID-19 and reported their association with poor clinical outcomes. Whether acute injury occurs during the course of critical care and if it is associated with cardiac function is unknown. The purpose of this study was to document the incidence of acute myocardial injury (AMInj) and echocardiographically defined left ventricular (LV) and right ventricular (RV) systolic dysfunction in consecutive patients admitted to an intensive care unit (ICU) for COVID-19. The relationship between AMInj and echocardiographic abnormalities during the first 14 days of ICU admission was studied. Finally, the association between echocardiographic findings, AMInj and clinical outcome was evaluated.\n\nSeventy-four consecutive patients (\u226518 years) admitted to the ICU at Link\u00f6ping University Hospital between 19 Mar 2020 and 31 Dec 2020 for COVID-19 were included. High-sensitivity troponin-T (hsTnT) was measured daily for up to 14 days. Transthoracic echocardiography was conducted within 72 h of ICU admission. Acute myocardial injury was defined as an increased hsTnT > 14ng/l and a > 20% absolute change with or without ischaemic symptoms. LV and RV systolic dysfunction was defined as at least 2 abnormal indicators of systolic function specified by consensus guidelines.\n\nIncreased hsTnT was observed in 59% of patients at ICU admission, and 82% developed AMInj with peak levels at 8 (3-13) days after ICU admission. AMInj was not statistically significantly associated with 30-day mortality but was associated with an increased duration of invasive mechanical ventilation (10 (3-13) vs. 5 days (0-9), p=0.001) as well as ICU length of stay (LOS) (19.5 (11-28) vs. 7 days (5-13), p=0.015). After adjustment for SAPS-3 and admission SOFA score, the effect of AMInj was significant only for the duration of mechanical ventilation (p=0.030). The incidence of LV and RV dysfunction was 28% and 22%, respectively. Only indices of LV and RV longitudinal contractility (mitral and tricuspid annular plane systolic excursion) were associated with AMInj. Echocardiographic parameters were not associated with clinical outcome.\n\nMyocardial injury is common in critically ill patients with COVID-19, with AMInj developing in more than 80% after ICU admission. In contrast, LV and RV dysfunction occurred in approximately one-quarter of patients. AMInj was associated with an increased need for mechanical ventilation and ICU LOS but neither AMInj nor ventricular dysfunction was significantly associated with mortality.", "doi": "10.1186/s13613-022-01030-8", "pmid": "35727386", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13613-022-01030-8"}, {"db": "pmc", "key": "PMC9210044"}], "notes": [], "created": "2022-08-17T13:05:26.592Z", "modified": "2022-08-17T13:05:26.639Z"}, {"entity": "publication", "iuid": "8c8b3c1318b14711a433112dcbf8867b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c8b3c1318b14711a433112dcbf8867b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c8b3c1318b14711a433112dcbf8867b"}}, "title": "Building social support: The impact of workgroup characteristics, the COVID-19 pandemic and informal interactions.", "authors": [{"family": "Pauksztat", "given": "Birgit", "initials": "B", "orcid": "0000-0002-2216-0836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c1db1125035420a81d17521e7a82755.json"}}, {"family": "Grech", "given": "Michelle R", "initials": "MR", "orcid": "0000-0002-3323-3607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b2aceb4dce745d780f36935b82dcb85.json"}}], "type": "journal article", "published": "2022-06-21", "journal": {"title": "Work", "issn": "1875-9270", "pages": "1175-1189", "volume": "72", "issue": "4", "issn-l": null}, "abstract": "Social support from colleagues is a key resource for employees and organizations, with beneficial effects on performance, employee well-being and resilience. Although the importance of social support is well-known, the factors that help to build and maintain social support are not equally well understood.\n\nThis study analyzes the impact of workgroup characteristics (i.e., workgroup composition regarding national diversity and tenure; workload) and the COVID-19 pandemic on employees' perceptions of instrumental and emotional support, and examines the mediating role of informal interactions.\n\nThe study is based on responses from 382 seafarers to a cross-sectional online survey. Hypotheses were tested using OLS regression and mediation analysis using PROCESS.\n\nWorkgroup composition regarding national diversity had indirect effects on social support through informal interactions around social foci (here: joint leisure activities). High workload and pressure from the COVID-19 pandemic reduced interactions around social foci, thus contributing to the erosion of perceived social support.\n\nThe findings provide insights on the development of social support, suggesting that informal interactions provide an important mechanism for the development of social support at work. From a theoretical perspective, this highlights the value of a relational perspective on the development of social support, a perspective that is based on the insight that social support is embedded in social relationships. From a practical point of view, this indicates that organizations can proactively foster the development of social support through practices that shape workgroup characteristics and social foci.", "doi": "10.3233/WOR-220020", "pmid": "35723163", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "WOR220020"}], "notes": [], "created": "2022-06-20T18:03:34.602Z", "modified": "2022-08-17T12:45:15.461Z"}, {"entity": "publication", "iuid": "10d1edf47a3741b49c5ce19be486db55", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/10d1edf47a3741b49c5ce19be486db55.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/10d1edf47a3741b49c5ce19be486db55"}}, "title": "Broadly Applicable, Virus-Free Dual Reporter Assay to Identify Compounds Interfering with Membrane Fusion: Performance for HSV-1 and SARS-CoV-2.", "authors": [{"family": "Classen", "given": "Nica", "initials": "N", "orcid": "0000-0002-2745-5748", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ac354339de048e4ba9a7903e4fe8c30.json"}}, {"family": "Ulrich", "given": "Diana", "initials": "D"}, {"family": "Hofemeier", "given": "Arne", "initials": "A"}, {"family": "Hennies", "given": "Marc Tim", "initials": "MT"}, {"family": "Hafezi", "given": "Wali", "initials": "W"}, {"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Romberg", "given": "Marie-Luise", "initials": "ML"}, {"family": "Lorentzen", "given": "Eva U", "initials": "EU", "orcid": "0000-0002-5570-1897", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9d0581149694958919de3f8fe6ef3cc.json"}}, {"family": "Hensel", "given": "Andreas", "initials": "A", "orcid": "0000-0003-0886-8384", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/458c0b3e8d9a47c083f86f80f542b582.json"}}, {"family": "K\u00fchn", "given": "Joachim E", "initials": "JE"}], "type": "journal article", "published": "2022-06-21", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "7", "issn-l": "1999-4915"}, "abstract": "Membrane fusion constitutes an essential step in the replication cycle of numerous viral pathogens, hence it represents an important druggable target. In the present study, we established a virus-free, stable reporter fusion inhibition assay (SRFIA) specifically designed to identify compounds interfering with virus-induced membrane fusion. The dual reporter assay is based on two stable Vero cell lines harboring the third-generation tetracycline (Tet3G) transactivator and a bicistronic reporter gene cassette under the control of the tetracycline responsive element (TRE3G), respectively. Cell-cell fusion by the transient transfection of viral fusogens in the presence of doxycycline results in the expression of the reporter enzyme secreted alkaline phosphatase (SEAP) and the fluorescent nuclear localization marker EYFPNuc. A constitutively expressed, secreted form of nanoluciferase (secNLuc) functioned as the internal control. The performance of the SRFIA was tested for the quantification of SARS-CoV-2- and HSV-1-induced cell-cell fusion, respectively, showing high sensitivity and specificity, as well as the reliable identification of known fusion inhibitors. Parallel quantification of secNLuc enabled the detection of cytotoxic compounds or insufficient transfection efficacy. In conclusion, the SRFIA reported here is well suited for high-throughput screening for new antiviral agents and essentially will be applicable to all viral fusogens causing cell-cell fusion in Vero cells.", "doi": "10.3390/v14071354", "pmid": "35891336", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "v14071354"}, {"db": "pmc", "key": "PMC9322530"}], "notes": [], "created": "2022-08-12T08:35:12.802Z", "modified": "2022-08-12T08:35:12.933Z"}, {"entity": "publication", "iuid": "0f95ab7453574fc49096b75980416597", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0f95ab7453574fc49096b75980416597.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0f95ab7453574fc49096b75980416597"}}, "title": "[Swedish gallstone surgery during the covid-19 pandemic].", "authors": [{"family": "Johan Drott", "given": "Carl", "initials": "C"}, {"family": "Sandblom", "given": "Gabriel", "initials": "G"}, {"family": "\u00d6sterberg", "given": "Johanna", "initials": "J"}, {"family": "Rogmark", "given": "Peder", "initials": "P"}, {"family": "Enochsson", "given": "Lars", "initials": "L"}], "type": "journal article", "published": "2022-06-20", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "volume": "119", "issn-l": "0023-7205"}, "abstract": "The covid-19 pandemic has necessitated reallocation of health care resources. This has raised concerns about the risks associated with postponing surgery for benign conditions that are given low priority. Data from the population-based Swedish National Register for Gallstone Surgery (GallRiks) show that the total number of procedures carried out during the initial months of each wave of the pandemic decreased. This was followed by a moderate increase in the number of procedures performed for acute cholecystitis, biliary pancreatitis, and obstructive jaundice. The consequences of the delayed surgery in the community at large and how this has affected health-related quality of life for patients having their procedure postponed remain to be evaluated, but so far it does not seem to have caused a major impact on public health.", "doi": null, "pmid": "35723571", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "21230"}], "notes": [], "created": "2022-08-17T12:44:12.527Z", "modified": "2022-08-17T12:44:12.540Z"}, {"entity": "publication", "iuid": "5b26867b6a75453abaea1cabf66361a3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5b26867b6a75453abaea1cabf66361a3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5b26867b6a75453abaea1cabf66361a3"}}, "title": "SARS-CoV-2 Specific Antibody Response and T Cell-Immunity in Immunocompromised Patients up to Six Months Post COVID: A Pilot Study.", "authors": [{"family": "Sj\u00f6wall", "given": "Johanna", "initials": "J", "orcid": "0000-0001-5622-866X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/352c62c6701e4bb89b3029d38803b9be.json"}}, {"family": "Hjorth", "given": "Maria", "initials": "M", "orcid": "0000-0002-4195-9387", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ccf79a5f280460aa963ce38b97bc5d7.json"}}, {"family": "Gustafsson", "given": "Annette", "initials": "A"}, {"family": "G\u00f6ransson", "given": "Robin", "initials": "R"}, {"family": "Larsson", "given": "Marie", "initials": "M", "orcid": "0000-0002-4524-0177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8d3f27eebb4456f965bc4da2c99176f.json"}}, {"family": "Waller", "given": "Hjalmar", "initials": "H"}, {"family": "Nordgren", "given": "Johan", "initials": "J", "orcid": "0000-0002-5349-2569", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad771e6e329b4442b045d31dddfdd8ec.json"}}, {"family": "Nilsdotter-Augustinsson", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0001-5719-5601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c315dcd94fd427ea248f6502de0229a.json"}}, {"family": "Nystr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0002-0145-4966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56bc7bc8ab444c81afd336394ae7607d.json"}}], "type": "journal article", "published": "2022-06-20", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "11", "issue": "12", "issn-l": "2077-0383"}, "abstract": "COVID-19 generates SARS-CoV-2-specific antibodies in immunocompetent individuals. However, in immunocompromised patients, the humoral immunity following infection may be impaired or absent. Recently, the assessment of cellular immunity to SARS-CoV-2, both following natural infection and vaccination, has contributed new knowledge regarding patients with low or no antibody responses. As part of a prospective cohort study which included hospitalized patients with COVID-19, we identified immunocompromised patients and compared them with age- and sex-matched immunocompetent patients regarding co-morbidities, biomarkers of COVID-19 and baseline viral load by real-time PCR in nasopharyngeal swabs. Spike and nucleocapsid antibody responses were analyzed at inclusion and after two weeks, six weeks and six months. Plasma immunoglobulin G (IgG) levels were quantified, lymphocyte phenotyping was performed, and SARS-CoV-2 specific CD4 and CD8 T cell responses after in vitro antigen stimulation were assessed at six months post infection. All patients showed IgG levels above or within reference limits. At six months, all patients had detectable SARS-CoV-2 anti-spike antibody levels. SARS-CoV-2 specific T cell responses were detected in 12 of 12 immunocompetent patients and in four of six immunocompromised patients. The magnitude of long-lived SARS-CoV-2 specific T cell responses were significantly correlated with the number of CD4 T cells and NK cells. Determining the durability of the humoral and cellular immune response against SARS-CoV-2 in immunocompromised individuals could be of importance by providing insights into the risk of re-infection and the need for vaccine boosters.", "doi": "10.3390/jcm11123535", "pmid": "35743605", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "jcm11123535"}, {"db": "pmc", "key": "PMC9225567"}], "notes": [], "created": "2022-08-19T05:44:04.368Z", "modified": "2022-08-19T05:44:22.039Z"}, {"entity": "publication", "iuid": "56677e17fc034e98afcf2e59f69e1242", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56677e17fc034e98afcf2e59f69e1242.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56677e17fc034e98afcf2e59f69e1242"}}, "title": "Integrating the CARD (Comfort Ask Relax Distract) system in a mass vaccination clinic to improve the experience of individuals during COVID-19 vaccination: a pre-post implementation study.", "authors": [{"family": "Tetui", "given": "Moses", "initials": "M"}, {"family": "Grindrod", "given": "Kelly", "initials": "K"}, {"family": "Waite", "given": "Nancy", "initials": "N"}, {"family": "VanderDoes", "given": "Jeremy", "initials": "J"}, {"family": "Taddio", "given": "Anna", "initials": "A", "orcid": "0000-0003-4432-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/383c983259be4b55b13c682f9d2a34bb.json"}}], "type": "journal article", "published": "2022-06-20", "journal": {"title": "Hum Vaccin Immunother", "issn": "2164-554X", "pages": "2089500", "issn-l": null}, "abstract": "Many people have negative experiences with vaccination due to stress-related reactions including fear and pain. We used a pre-post study design to evaluate the impact of implementing a modified version of the CARD (Comfort-Ask-Relax-Distract) system on stress-related reactions in individuals aged 12 y or older undergoing COVID-19 vaccinations in mass vaccination clinics. Vaccine recipients reported their level of pain, fear and dizziness during vaccination. Clinic staff reported their attitudes about CARD and use of CARD interventions. CARD improved client symptoms across genders and ages with an average reduction in needle pain, fear and dizziness of 75%, 40% and 44%, respectively. CARD was more effective in younger individuals. Clinic staff reported positive attitudes about CARD and uptake of selected CARD interventions. In summary, the modified CARD system reduced stress-related responses in a general population undergoing COVID-19 vaccinations in a mass vaccination clinic, was feasible and acceptable to staff. Future implementation efforts are recommended that include more diverse cultural contexts and incorporate education of individuals about CARD ahead of time.", "doi": "10.1080/21645515.2022.2089500", "pmid": "35723609", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-20T18:02:30.194Z", "modified": "2022-08-17T12:43:56.064Z"}, {"entity": "publication", "iuid": "c70af74a320e4b07ab68d297de9790b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c70af74a320e4b07ab68d297de9790b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c70af74a320e4b07ab68d297de9790b4"}}, "title": "Increase in admission rates and symptom severity of childhood and adolescent anorexia nervosa in Europe during the COVID-19 pandemic: data from specialized eating disorder units in different European countries.", "authors": [{"family": "Gilsbach", "given": "Susanne", "initials": "S"}, {"family": "Plana", "given": "Maria Teresa", "initials": "MT"}, {"family": "Castro-Fornieles", "given": "Josefina", "initials": "J"}, {"family": "Gatta", "given": "Michela", "initials": "M"}, {"family": "Karlsson", "given": "Gunilla Paulson", "initials": "GP"}, {"family": "Flamarique", "given": "Itziar", "initials": "I"}, {"family": "Raynaud", "given": "Jean-Philippe", "initials": "JP"}, {"family": "Riva", "given": "Anna", "initials": "A"}, {"family": "Solberg", "given": "Anne-Line", "initials": "AL"}, {"family": "van Elburg", "given": "Annemarie A", "initials": "AA"}, {"family": "Wentz", "given": "Elisabet", "initials": "E"}, {"family": "Nacinovich", "given": "Renata", "initials": "R"}, {"family": "Herpertz-Dahlmann", "given": "Beate", "initials": "B"}], "type": "journal article", "published": "2022-06-20", "journal": {"title": "Child Adolesc Psychiatry Ment Health", "issn": "1753-2000", "volume": "16", "issue": "1", "pages": "46", "issn-l": null}, "abstract": "The COVID-19 pandemic, associated with confinement and social isolation, seems to have impacted the course of many mental disorders in children and adolescents. An increase in hospital admission rates for juvenile anorexia nervosa (AN) has been documented in many regions of the world. However, data from Europe are scarce.\n\nWe asked clinicians in specialized eating disorder units in hospitals of maximum care in France, Germany, Italy, Spain, Sweden, and the Netherlands to report on (i) overall (inpatient and outpatient) and (ii) inpatient admission rates for adolescents with AN during 2019 and 2020. Additionally, a modified version of the COVID Isolation Eating Scale (CIES) was used to assess the child and adolescent psychiatrists' estimations of a possible increase in symptom severity in children and adolescents with AN during the COVID-19 pandemic and to (iii) inquire about the contributing factors perceived by the caring professionals.\n\nFour out of six representatives of European hospitals described a higher rate of overall admissions during the pandemic. Three hospitals out of six reported an increase in inpatient admissions, and two centres had constant high numbers of admissions of both outpatients and inpatients. The clinicians perceived a higher symptom severity in 2020 than in 2019, especially involving more frequent use of social media, longer duration of exercising, and more restrictive eating. They supposed an increase in social media consumption, a perceived \"loss of control\", and a lack of in-person assessments and weight controls as the main contributing factors for the deterioration in AN numbers and symptomatology.\n\nThe COVID-19 pandemic seems to have had a deep impact on symptom severity in AN, which is mirrored by a large increase in admission rates across Europe. An increase in exercise, social media consumption, a perceived \"loss of control\", and a lack of face-to-face health care seem to have contributed to this development. Further investigation is required to identify which factors may lead to the increase in incidence and deterioration of childhood and adolescent AN. Possible preventive means for the future could include educating paediatricians and health care workers about AN, regular weight assessment, and home-based treatments.", "doi": "10.1186/s13034-022-00482-x", "pmid": "35725621", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13034-022-00482-x"}, {"db": "pmc", "key": "PMC9208345"}], "notes": [], "created": "2022-08-17T13:04:58.818Z", "modified": "2022-08-17T13:04:58.831Z"}, {"entity": "publication", "iuid": "fa8fe4b9a71a4f3390db169213dcc235", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa8fe4b9a71a4f3390db169213dcc235.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa8fe4b9a71a4f3390db169213dcc235"}}, "title": "COVID-19 conspiracy ideation is associated with the delusion proneness trait and resistance to update of beliefs.", "authors": [{"family": "Acar", "given": "K", "initials": "K"}, {"family": "Horntvedt", "given": "O", "initials": "O"}, {"family": "Cabrera", "given": "A", "initials": "A"}, {"family": "Olsson", "given": "A", "initials": "A"}, {"family": "Ingvar", "given": "M", "initials": "M"}, {"family": "Lebedev", "given": "A V", "initials": "AV"}, {"family": "Petrovic", "given": "P", "initials": "P"}], "type": "journal article", "published": "2022-06-20", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "10352", "issn-l": "2045-2322"}, "abstract": "The rapid spread of conspiracy ideas associated with the recent COVID-19 pandemic represents a major threat to the ongoing and coming vaccination programs. Yet, the cognitive factors underlying the pandemic-related conspiracy beliefs are not well described. We hypothesized that such cognitive style is driven by delusion proneness, a trait phenotype associated with formation of delusion-like beliefs that exists on a continuum in the normal population. To probe this hypothesis, we developed a COVID-19 conspiracy questionnaire (CCQ) and assessed 577 subjects online. Their responses clustered into three factors that included Conspiracy, Distrust and Fear/Action as identified using principal component analysis. We then showed that CCQ (in particular the Conspiracy and Distrust factors) related both to general delusion proneness assessed with Peter's Delusion Inventory (PDI) as well as resistance to belief update using a Bias Against Disconfirmatory Evidence (BADE) task. Further, linear regression and pathway analyses suggested a specific contribution of BADE to CCQ not directly explained by PDI. Importantly, the main results remained significant when using a truncated version of the PDI where questions on paranoia were removed (in order to avoid circular evidence), and when adjusting for ADHD- and autistic traits (that are known to be substantially related to delusion proneness). Altogether, our results strongly suggest that pandemic-related conspiracy ideation is associated with delusion proneness trait phenotype.", "doi": "10.1038/s41598-022-14071-7", "pmid": "35725585", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-14071-7"}, {"db": "pmc", "key": "PMC9208343"}], "notes": [], "created": "2022-08-17T13:04:41.886Z", "modified": "2022-08-17T13:04:41.892Z"}, {"entity": "publication", "iuid": "ef5e6ee82251415ab0690481ddfaf624", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef5e6ee82251415ab0690481ddfaf624.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef5e6ee82251415ab0690481ddfaf624"}}, "title": "Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir.", "authors": [{"family": "Jemth", "given": "Ann-Sofie", "initials": "AS"}, {"family": "Scaletti", "given": "Emma Rose", "initials": "ER"}, {"family": "Homan", "given": "Evert", "initials": "E"}, {"family": "Stenmark", "given": "P\u00e5l", "initials": "P"}, {"family": "Helleday", "given": "Thomas", "initials": "T"}, {"family": "Michel", "given": "Maurice", "initials": "M"}], "type": "journal article", "published": "2022-06-19", "journal": {"title": "J Biol Chem", "issn": "1083-351X", "volume": "298", "issue": "8", "pages": "102169", "issn-l": "0021-9258"}, "abstract": "Remdesivir and molnupiravir have gained considerable interest because of their demonstrated activity against SARS-CoV-2. These antivirals are converted intracellularly to their active triphosphate forms remdesivir-TP and molnupiravir-TP. Cellular hydrolysis of these active metabolites would consequently decrease the efficiency of these drugs; however, whether endogenous enzymes that can catalyze this hydrolysis exist is unknown. Here, we tested remdesivir-TP as a substrate against a panel of human hydrolases and found that only Nudix hydrolase (NUDT) 18 catalyzed the hydrolysis of remdesivir-TP with notable activity. The kcat/Km value of NUDT18 for remdesivir-TP was determined to be 17,700 s-1M-1, suggesting that NUDT18-catalyzed hydrolysis of remdesivir-TP may occur in cells. Moreover, we demonstrate that the triphosphates of the antivirals ribavirin and molnupiravir are also hydrolyzed by NUDT18, albeit with lower efficiency than Remdesivir-TP. Low activity was also observed with the triphosphate forms of sofosbuvir and aciclovir. This is the first report showing that NUDT18 hydrolyzes triphosphates of nucleoside analogs of exogenous origin, suggesting that NUDT18 can act as a cellular sanitizer of modified nucleotides and may influence the antiviral efficacy of remdesivir, molnupiravir, and ribavirin. As NUDT18 is expressed in respiratory epithelial cells, it may limit the antiviral efficacy of remdesivir and molnupiravir against SARS-CoV-2 replication by decreasing the intracellular concentration of their active metabolites at their intended site of action.", "doi": "10.1016/j.jbc.2022.102169", "pmid": "35732208", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0021-9258(22)00611-1"}, {"db": "pmc", "key": "PMC9212496"}], "notes": [], "created": "2022-08-19T05:52:40.420Z", "modified": "2022-08-19T05:52:40.432Z"}, {"entity": "publication", "iuid": "f81a5edc998b42078e254d2da59c4dc0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f81a5edc998b42078e254d2da59c4dc0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f81a5edc998b42078e254d2da59c4dc0"}}, "title": "Sensitization-Associated Post-COVID-19 Symptoms at 6 Months Are Not Associated with Serological Biomarkers at Hospital Admission in COVID-19 Survivors: A Secondary Analysis of a Cohort Study.", "authors": [{"family": "Fern\u00e1ndez-de-Las-Pe\u00f1as", "given": "C\u00e9sar", "initials": "C", "orcid": "0000-0003-3772-9690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f64421a4c1b343f1a1bc17e02236f386.json"}}, {"family": "Herrero-Montes", "given": "Manuel", "initials": "M", "orcid": "0000-0002-5732-8344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3460d36201934582b42366a9e2e736c0.json"}}, {"family": "Ferrer-Pargada", "given": "Diego", "initials": "D"}, {"family": "Izquierdo-Cuervo", "given": "Sheila", "initials": "S"}, {"family": "Arendt-Nielsen", "given": "Lars", "initials": "L", "orcid": "0000-0003-0892-1579", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d147964e28949a49f9572be5317fc04.json"}}, {"family": "Nijs", "given": "Jo", "initials": "J", "orcid": "0000-0002-4976-6563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4c1747ed07f4ef6a09c589a4a9c9f2d.json"}}, {"family": "Par\u00e1s-Bravo", "given": "Paula", "initials": "P", "orcid": "0000-0001-7745-3006", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef0603c7d86b4098b44cfb4aeea8785f.json"}}], "type": "journal article", "published": "2022-06-18", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "11", "issue": "12", "issn-l": "2077-0383"}, "abstract": "Individuals who survived coronavirus disease, 2019 (COVID-19), often have symptoms of sensitization, but the extent to which these symptoms relate to serological biomarkers remains unclear. Therefore, this secondary analysis evaluated the association between serological biomarkers at hospital admission with sensitization-associated post-COVID-19 symptoms in a sample of previously hospitalized COVID-19 survivors. Sixty-seven individuals hospitalized due to SARS-CoV-2 infection in one urban hospital of Madrid (Spain) during the first wave of the pandemic were assessed a mean of 6.0 (SD 0.8) months after hospital discharge. The Central Sensitization Inventory (CSI) was used as rough tool to estimate the presence of sensitization-associated post-COVID-19 symptoms (\u226540/100 points). Levels of 16 serological biomarkers collected at hospital admission were obtained from medical records. Twenty-four (35.8%) patients reported sensitization-associated post-COVID-19 symptoms (CSI \u2265 40 points). Subjects reporting sensitization-associated symptoms had lower ferritin and hemoglobin levels than those not reporting sensitization-associated post-COVID-19 symptoms; however, these differences were small. We observed significant but small negative associations of the CSI score with ferritin (r: -0.251, p = 0.04) and hemoglobin (r: -0.292, p = 0.017) levels. No other significant difference was found. In conclusion, this secondary analysis did not find significant associations between the investigated serological biomarkers at hospital admission and sensitization-associated post-COVID-19 symptoms at 6 months after hospitalization in COVID-19 survivors.", "doi": "10.3390/jcm11123512", "pmid": "35743582", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "jcm11123512"}, {"db": "pmc", "key": "PMC9225549"}], "notes": [], "created": "2022-08-19T05:44:48.081Z", "modified": "2022-08-19T05:44:48.243Z"}, {"entity": "publication", "iuid": "348b1fa1816746bf9c15e7c4861df2ce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/348b1fa1816746bf9c15e7c4861df2ce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/348b1fa1816746bf9c15e7c4861df2ce"}}, "title": "Healthcare Professionals' Experience of Performing Digital Care Visits-A Scoping Review.", "authors": [{"family": "Lampickien\u0117", "given": "Ieva", "initials": "I"}, {"family": "Davoody", "given": "Nadia", "initials": "N", "orcid": "0000-0003-1813-8529", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/842dc06d06834029b4621c61a2623667.json"}}], "type": "journal article", "published": "2022-06-17", "journal": {"title": "Life (Basel)", "issn": "2075-1729", "volume": "12", "issue": "6", "issn-l": null}, "abstract": "The use of digital care visits has been increasing during the COVID-19 pandemic. Learning more about healthcare professionals' technology experiences provides valuable insight and a basis for improving digital visits. This study aimed to explore the existing literature on healthcare professionals' experience performing digital care visits. A scoping review was performed following Arksey & O'Malley's proposed framework using the Preferred Reporting Items for Systematic reviews and Meta-Analyses. The collected data were analyzed using thematic content analysis. Five main themes were identified in the literature: positive experiences/benefits, facilitators, negative experiences/challenges, barriers, and suggestions for improvement. Healthcare professionals mostly reported having an overall positive experience with digital visits and discovered benefits for themselves and the patients. However, opinions were mixed or negative regarding the complexity of decision making, workload and workflow, suitability of this type of care, and other challenges. The suggestions for improvement included training and education, improvements within the system and tools, along with support for professionals. Despite overall positive experiences and benefits for both professionals and patients, clinicians reported challenges such as physical barriers, technical issues, suitability concerns, and others. Digital care visits could not fully replace face-to-face visits.", "doi": "10.3390/life12060913", "pmid": "35743944", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "life12060913"}, {"db": "pmc", "key": "PMC9225275"}], "notes": [], "created": "2022-08-19T05:43:44.038Z", "modified": "2022-08-19T05:43:44.094Z"}, {"entity": "publication", "iuid": "983f426f18fc4baea38dc85d6d68cc0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/983f426f18fc4baea38dc85d6d68cc0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/983f426f18fc4baea38dc85d6d68cc0e"}}, "title": "COVID-19 vaccination-related adverse events among autoimmune disease patients: results from the COVAD study.", "authors": [{"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "R", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Kardes", "given": "Sinan", "initials": "S", "orcid": "0000-0002-6311-8634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2900c3ca00da476a8914574384a3c9c2.json"}}, {"family": "Kim", "given": "Minchul", "initials": "M", "orcid": "0000-0001-9737-6255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd2952c6167b4733bfbce019a162b310.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "O'Callaghan", "given": "Albert Selva", "initials": "AS", "orcid": "0000-0003-2823-9761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef3e202c049b44a2a5e045bac90a393a.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "COVAD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-06-17", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "issn-l": null}, "abstract": "COVID-19 vaccines have been proven to be safe in the healthy population. However, gaps remain in the evidence of their safety in patients with systemic autoimmune and inflammatory disorders (SAIDs). COVID-19 vaccination related adverse events (ADEs) in patients with SAIDs and healthy controls (HC) seven days post-vaccination were assessed in the COVAD study, a patient self-reported cross-sectional survey.\n\nThe survey was circulated in early 2021 by > 110 collaborators (94 countries) to collect SAID details, COVID-19 vaccination details, and 7-day vaccine ADEs, irrespective of respondent vaccination status. Analysis was performed based on data distribution and variable type.\n\n10900 respondents [42 (30-55) years, 74% females and 45% Caucasians] were analyzed. 5,867 patients (54%) with SAIDs were compared with 5033 HCs.79% had minor and only 3% had major vaccine ADEs requiring urgent medical attention (but not hospital admission) overall. Headache [SAIDs=26%, HCs=24%; OR = 1.1 (1.03-1.3); p = 0.014], abdominal pain [SAIDs=2.6%, HCs=1.4%; OR = 1.5 (1.1-2.3); p = 0.011], and dizziness [SAIDs=6%, HCs=4%; OR = 1.3 (1.07-1.6); p = 0.011], were slightly more frequent in SAIDs. Overall, major ADEs [SAIDs=4%, HCs=2%; OR = 1.9 (1.6-2.2); p < 0.001] and, specifically, throat closure [SAIDs=0.5%, HCs=0.3%; OR = 5.7 (2.9-11); p = 0.010] were more frequent in SAIDs though absolute risk was small (0-4%). Major ADEs and hospitalizations (less than 2%) were comparable across vaccine types in SAIDs.\n\nVaccination against COVID-19 is relatively safe in SAID patients. SAIDs were at a higher risk of major ADEs than HCs, though absolute risk was small. There are small differences in minor ADEs between vaccine types in SAID patients.", "doi": "10.1093/rheumatology/keac305", "pmid": "35713499", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6609762"}, {"db": "pmc", "key": "PMC9214139"}], "notes": [], "created": "2022-06-20T18:06:19.191Z", "modified": "2022-08-17T12:47:13.086Z"}, {"entity": "publication", "iuid": "556f775a8812436895594f18d49067f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/556f775a8812436895594f18d49067f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/556f775a8812436895594f18d49067f8"}}, "title": "Public anxiety through various stages of COVID-19 coping: Evidence from China.", "authors": [{"family": "Wu", "given": "Yangyang", "initials": "Y"}, {"family": "Zhang", "given": "Ting", "initials": "T"}, {"family": "Ye", "given": "Ziwen", "initials": "Z"}, {"family": "Chen", "given": "Kai", "initials": "K"}, {"family": "Kuijp", "given": "J van der", "initials": "JV"}, {"family": "Sun", "given": "Xue", "initials": "X"}, {"family": "Han", "given": "Guoyi", "initials": "G"}, {"family": "Zhao", "given": "Yi", "initials": "Y"}, {"family": "Liu", "given": "Yang", "initials": "Y", "orcid": "0000-0001-5477-2186", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43230a960dd84a27ba4777fcd2a0f189.json"}}, {"family": "Huang", "given": "Lei", "initials": "L", "orcid": "0000-0002-9279-878X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5bad866d23b4fd3902a7214f88f5484.json"}}], "type": "journal article", "published": "2022-06-16", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "6", "pages": "e0270229", "issn-l": "1932-6203"}, "abstract": "As countries underwent the initiation, peak, post-peak, and early vaccination stages of COVID-19, the changing risk perception, coping behaviors and corresponding psychological stress experienced by the public over time was rarely reported. We conducted a national scale panel study using social-psychological data collected from 5,983 questionnaires to investigate the interactions between anxiety level, risk perception and coping behavior during different stages of COVID-19 in China. We found that sustained perceiving worries of being infected, first due to domestic and then global pandemic, contributed to the persistent high proportion of respondents with anxiety disorders which even gradually increased over time (56.1% during initiation to 60.4% during early vaccination). Gender was the strongest predictor of anxiety at all stages, with females having less confidence in COVID-19 control and always suffering from much higher anxiety levels than males even during the post peak stage. Excessive protective behavior and frequency of access to COVID-related news also contributed to public anxiety. Additionally, public risk perception was significantly associated with their willingness to vaccinate. The findings verify the feasibility of taking stage-specific and gender-based risk communication strategies to alleviate the pandemic-related public anxiety and promote vaccination by influencing public risk perception and guiding coping behaviors.", "doi": "10.1371/journal.pone.0270229", "pmid": "35709292", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-22-05358"}, {"db": "pmc", "key": "PMC9202924"}], "notes": [], "created": "2022-06-20T18:07:18.211Z", "modified": "2022-08-17T12:47:43.967Z"}, {"entity": "publication", "iuid": "6c7c15fd98be42c6bff33bc2dd174b0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c7c15fd98be42c6bff33bc2dd174b0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c7c15fd98be42c6bff33bc2dd174b0e"}}, "title": "Novel genes and sex differences in COVID-19 severity.", "authors": [{"family": "Cruz", "given": "Raquel", "initials": "R", "orcid": "0000-0002-6964-8898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5697ffeaef2b40b584dc400b00544e76.json"}}, {"family": "Almeida", "given": "Silvia Diz-de", "initials": "SD"}, {"family": "Heredia", "given": "Miguel L\u00f3pez", "initials": "ML"}, {"family": "Quintela", "given": "In\u00e9s", "initials": "I"}, {"family": "Ceballos", "given": "Francisco C", "initials": "FC"}, {"family": "Pita", "given": "Guillermo", "initials": "G"}, {"family": "Lorenzo-Salazar", "given": "Jos\u00e9 M", "initials": "JM"}, {"family": "Gonz\u00e1lez-Montelongo", "given": "Rafaela", "initials": "R"}, {"family": "Gago-Dom\u00ednguez", "given": "Manuela", "initials": "M"}, {"family": "Porras", "given": "Marta Sevilla", "initials": "MS"}, {"family": "Casta\u00f1o", "given": "Jair Antonio Tenorio", "initials": "JAT"}, {"family": "Nevado", "given": "Julian", "initials": "J"}, {"family": "Aguado", "given": "Jose Mar\u00eda", "initials": "JM"}, {"family": "Aguilar", "given": "Carlos", "initials": "C"}, {"family": "Aguilera-Albesa", "given": "Sergio", "initials": "S"}, {"family": "Almadana", "given": "Virginia", "initials": "V"}, {"family": "Almoguera", "given": "Berta", "initials": "B"}, {"family": "Alvarez", "given": "Nuria", "initials": "N"}, {"family": "Andreu-Bernabeu", "given": "\u00c1lvaro", "initials": "\u00c1"}, {"family": "Arana-Arri", "given": "Eunate", "initials": "E"}, {"family": "Arango", "given": "Celso", "initials": "C"}, {"family": "Arranz", "given": "Mar\u00eda J", "initials": "MJ"}, {"family": "Artiga", "given": "Maria-Jesus", "initials": "MJ"}, {"family": "Baptista-Rosas", "given": "Ra\u00fal C", "initials": "RC"}, {"family": "Barreda-S\u00e1nchez", "given": "Mar\u00eda", "initials": "M"}, {"family": "Belhassen-Garcia", "given": "Moncef", "initials": "M"}, {"family": "Bezerra", "given": "Joao F", "initials": "JF"}, {"family": "Bezerra", "given": "Marcos A C", "initials": "MAC"}, {"family": "Boix-Palop", "given": "Luc\u00eda", "initials": "L"}, {"family": "Brion", "given": "Mar\u00eda", "initials": "M", "orcid": "0000-0001-7463-2148", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cd3234359d94481abd8238f3c3086cc.json"}}, {"family": "Brugada", "given": "Ram\u00f3n", "initials": "R"}, {"family": "Bustos", "given": "Matilde", "initials": "M"}, {"family": "Calder\u00f3n", "given": "Enrique J", "initials": "EJ", "orcid": "0000-0002-3166-5086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ec00f43e1fb43c6b754a31cbe723bbf.json"}}, {"family": "Carbonell", "given": "Cristina", "initials": "C"}, {"family": "Castano", "given": "Luis", "initials": "L"}, {"family": "Castelao", "given": "Jose E", "initials": "JE"}, {"family": "Conde-Vicente", "given": "Rosa", "initials": "R"}, {"family": "Cordero-Lorenzana", "given": "M Lourdes", "initials": "ML"}, {"family": "Cortes-Sanchez", "given": "Jose L", "initials": "JL"}, {"family": "Corton", "given": "Marta", "initials": "M"}, {"family": "Darnaude", "given": "M Teresa", "initials": "MT"}, {"family": "De Martino-Rodr\u00edguez", "given": "Alba", "initials": "A"}, {"family": "Campo-P\u00e9rez", "given": "Victor", "initials": "V"}, {"family": "Bustamante", "given": "Aranzazu Diaz", "initials": "AD"}, {"family": "Dom\u00ednguez-Garrido", "given": "Elena", "initials": "E"}, {"family": "Luchessi", "given": "Andre D", "initials": "AD"}, {"family": "Eir\u00f3s", "given": "Roc\u00edo", "initials": "R"}, {"family": "Sanabria", "given": "Gladys Mercedes Estigarribia", "initials": "GME"}, {"family": "Fari\u00f1as", "given": "Mar\u00eda Carmen", "initials": "MC"}, {"family": "Fern\u00e1ndez-Robelo", "given": "Ux\u00eda", "initials": "U"}, {"family": "Fern\u00e1ndez-Rodr\u00edguez", "given": "Amanda", "initials": "A"}, {"family": "Fern\u00e1ndez-Villa", "given": "Tania", "initials": "T"}, {"family": "Gil-Fournier", "given": "Bel\u00e9n", "initials": "B"}, {"family": "G\u00f3mez-Arrue", "given": "Javier", "initials": "J"}, {"family": "\u00c1lvarez", "given": "Beatriz Gonz\u00e1lez", "initials": "BG"}, {"family": "Quir\u00f3s", "given": "Fernan Gonzalez Bernaldo", "initials": "FGB"}, {"family": "Gonz\u00e1lez-Pe\u00f1as", "given": "Javier", "initials": "J"}, {"family": "Guti\u00e9rrez-Bautista", "given": "Juan F", "initials": "JF", "orcid": "0000-0003-1374-0756", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a426ebb240a54f0ab776e410f9244b70.json"}}, {"family": "Herrero", "given": "Mar\u00eda Jos\u00e9", "initials": "MJ"}, {"family": "Herrero-Gonzalez", "given": "Antonio", "initials": "A"}, {"family": "Jimenez-Sousa", "given": "Mar\u00eda A", "initials": "MA"}, {"family": "Lattig", "given": "Mar\u00eda Claudia", "initials": "MC"}, {"family": "Borja", "given": "Anabel Liger", "initials": "AL"}, {"family": "Lopez-Rodriguez", "given": "Rosario", "initials": "R"}, {"family": "Mancebo", "given": "Esther", "initials": "E"}, {"family": "Mart\u00edn-L\u00f3pez", "given": "Caridad", "initials": "C"}, {"family": "Mart\u00edn", "given": "Vicente", "initials": "V"}, {"family": "Martinez-Nieto", "given": "Oscar", "initials": "O"}, {"family": "Martinez-Lopez", "given": "Iciar", "initials": "I"}, {"family": "Martinez-Resendez", "given": "Michel F", "initials": "MF"}, {"family": "Martinez-Perez", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "Mazzeu", "given": "Juliana A", "initials": "JA"}, {"family": "Mac\u00edas", "given": "Eleuterio Merayo", "initials": "EM"}, {"family": "Minguez", "given": "Pablo", "initials": "P"}, {"family": "Cuerda", "given": "Victor Moreno", "initials": "VM"}, {"family": "Silbiger", "given": "Vivian N", "initials": "VN"}, {"family": "Oliveira", "given": "Silviene F", "initials": "SF"}, {"family": "Ortega-Paino", "given": "Eva", "initials": "E"}, {"family": "Parellada", "given": "Mara", "initials": "M"}, {"family": "Paz-Artal", "given": "Estela", "initials": "E"}, {"family": "Santos", "given": "Ney P C", "initials": "NPC"}, {"family": "P\u00e9rez-Matute", "given": "Patricia", "initials": "P"}, {"family": "Perez", "given": "Patricia", "initials": "P"}, {"family": "P\u00e9rez-Tom\u00e1s", "given": "M Elena", "initials": "ME"}, {"family": "Perucho", "given": "Teresa", "initials": "T"}, {"family": "Pinsach-Abuin", "given": "Mel Lina", "initials": "ML"}, {"family": "Pompa-Mera", "given": "Ericka N", "initials": "EN"}, {"family": "Porras-Hurtado", "given": "Gloria L", "initials": "GL"}, {"family": "Pujol", "given": "Aurora", "initials": "A"}, {"family": "Le\u00f3n", "given": "Soraya Ramiro", "initials": "SR"}, {"family": "Resino", "given": "Salvador", "initials": "S"}, {"family": "Fernandes", "given": "Marianne R", "initials": "MR"}, {"family": "Rodr\u00edguez-Ruiz", "given": "Emilio", "initials": "E"}, {"family": "Rodriguez-Artalejo", "given": "Fernando", "initials": "F"}, {"family": "Rodriguez-Garcia", "given": "Jos\u00e9 A", "initials": "JA"}, {"family": "Ruiz-Cabello", "given": "Francisco", "initials": "F"}, {"family": "Ruiz-Hornillos", "given": "Javier", "initials": "J"}, {"family": "Ryan", "given": "Pablo", "initials": "P"}, {"family": "Soria", "given": "Jos\u00e9 Manuel", "initials": "JM"}, {"family": "Souto", "given": "Juan Carlos", "initials": "JC"}, {"family": "Tamayo", "given": "Eduardo", "initials": "E"}, {"family": "Tamayo-Velasco", "given": "Alvaro", "initials": "A"}, {"family": "Taracido-Fernandez", "given": "Juan Carlos", "initials": "JC"}, {"family": "Teper", "given": "Alejandro", "initials": "A"}, {"family": "Torres-Tobar", "given": "Lilian", "initials": "L"}, {"family": "Urioste", "given": "Miguel", "initials": "M"}, {"family": "Valencia-Ramos", "given": "Juan", "initials": "J"}, {"family": "Y\u00e1\u00f1ez", "given": "Zuleima", "initials": "Z"}, {"family": "Zarate", "given": "Ruth", "initials": "R"}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T", "orcid": "0000-0001-9510-5646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd273e50091d44c3b3e8d1473ce89b0a.json"}}, {"family": "Pigazzini", "given": "Sara", "initials": "S"}, {"family": "Degenhardt", "given": "Frauke", "initials": "F", "orcid": "0000-0001-7516-3179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab8dc6a0eb504f41a89c140d68b87b6a.json"}}, {"family": "Butler-Laporte", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-5388-0396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/529dc69151d3463e8480b975d70fa759.json"}}, {"family": "Maya-Miles", "given": "Douglas", "initials": "D"}, {"family": "Bujanda", "given": "Luis", "initials": "L"}, {"family": "Bouysran", "given": "Youssef", "initials": "Y"}, {"family": "Palom", "given": "Adriana", "initials": "A"}, {"family": "Ellinghaus", "given": "David", "initials": "D"}, {"family": "Mart\u00ednez-Bueno", "given": "Manuel", "initials": "M"}, {"family": "Rolker", "given": "Selina", "initials": "S"}, {"family": "Amitrano", "given": "Sara", "initials": "S"}, {"family": "Roade", "given": "Luisa", "initials": "L"}, {"family": "Fava", "given": "Francesca", "initials": "F"}, {"family": "Spinner", "given": "Christoph D", "initials": "CD", "orcid": "0000-0002-3875-5367", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c506eb763b34155bbc6187f4ccb5f62.json"}}, {"family": "Prati", "given": "Daniele", "initials": "D"}, {"family": "Bernardo", "given": "David", "initials": "D"}, {"family": "Garcia", "given": "Federico", "initials": "F"}, {"family": "Darcis", "given": "Gilles", "initials": "G"}, {"family": "Fern\u00e1ndez-Cadenas", "given": "Israel", "initials": "I"}, {"family": "Holter", "given": "Jan Cato", "initials": "JC"}, {"family": "Banales", "given": "Jesus M", "initials": "JM"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Duga", "given": "Stefano", "initials": "S"}, {"family": "Asselta", "given": "Rosanna", "initials": "R"}, {"family": "Pereira", "given": "Alexandre C", "initials": "AC"}, {"family": "Romero-G\u00f3mez", "given": "Manuel", "initials": "M"}, {"family": "Nafr\u00eda-Jim\u00e9nez", "given": "Beatriz", "initials": "B"}, {"family": "Hov", "given": "Johannes R", "initials": "JR"}, {"family": "Migeotte", "given": "Isabelle", "initials": "I"}, {"family": "Renieri", "given": "Alessandra", "initials": "A", "orcid": "0000-0003-3818-0871", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b23966a465254ca6bbcd2c8ded62de72.json"}}, {"family": "Planas", "given": "Anna M", "initials": "AM"}, {"family": "Ludwig", "given": "Kerstin U", "initials": "KU", "orcid": "0000-0002-8541-2519", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02922a1f71c64a8e9dc6aa1c29a20270.json"}}, {"family": "Buti", "given": "Maria", "initials": "M"}, {"family": "Rahmouni", "given": "Souad", "initials": "S"}, {"family": "Alarc\u00f3n-Riquelme", "given": "Marta E", "initials": "ME"}, {"family": "Schulte", "given": "Eva C", "initials": "EC"}, {"family": "Franke", "given": "Andre", "initials": "A"}, {"family": "Karlsen", "given": "Tom H", "initials": "TH"}, {"family": "Valenti", "given": "Luca", "initials": "L"}, {"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "Richards", "given": "Brent", "initials": "B"}, {"family": "Ganna", "given": "Andrea", "initials": "A"}, {"family": "Boada", "given": "Merc\u00e8", "initials": "M"}, {"family": "Rojas", "given": "Itziar", "initials": "I"}, {"family": "Ruiz", "given": "Agust\u00edn", "initials": "A"}, {"family": "S\u00e1nchez", "given": "Pascual", "initials": "P"}, {"family": "Real", "given": "Luis Miguel", "initials": "LM"}, {"family": "SCOURGE Cohort Group", "given": "", "initials": ""}, {"family": "HOSTAGE Cohort Group", "given": "", "initials": ""}, {"family": "GRA@CE Cohort Group", "given": "", "initials": ""}, {"family": "Guillen-Navarro", "given": "Encarna", "initials": "E"}, {"family": "Ayuso", "given": "Carmen", "initials": "C"}, {"family": "Gonz\u00e1lez-Neira", "given": "Anna", "initials": "A"}, {"family": "Riancho", "given": "Jos\u00e9 A", "initials": "JA"}, {"family": "Rojas-Martinez", "given": "Augusto", "initials": "A", "orcid": "0000-0003-3765-6778", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e1011d5dcbe44319ea2cd8a03e63105.json"}}, {"family": "Flores", "given": "Carlos", "initials": "C"}, {"family": "Lapunzina", "given": "Pablo", "initials": "P"}, {"family": "Carracedo", "given": "\u00c1ngel", "initials": "\u00c1"}], "type": "journal article", "published": "2022-06-16", "journal": {"title": "Hum Mol Genet", "issn": "1460-2083", "issn-l": null}, "abstract": "Here we describe the results of a genome-wide study conducted in 11 939 COVID-19 positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (p < 5x10-8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (p = 1.3x10-22 and p = 8.1x10-12, respectively), and for variants in 9q21.32 near TLE1 only among females (p = 4.4x10-8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (p = 2.7x10-8) and ARHGAP33 (p = 1.3x10-8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, p = 4.1x10-8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or \u2265 60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.", "doi": "10.1093/hmg/ddac132", "pmid": "35708486", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6607933"}], "notes": [], "created": "2022-06-20T18:08:48.923Z", "modified": "2022-08-17T12:48:40.142Z"}, {"entity": "publication", "iuid": "2be82183ca284e4181fb956bc2d63ab6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2be82183ca284e4181fb956bc2d63ab6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2be82183ca284e4181fb956bc2d63ab6"}}, "title": "Lifestyle behaviors in Swedish university students before and during the first six months of the COVID-19 pandemic: a cohort study.", "authors": [{"family": "Larsson", "given": "Kristina", "initials": "K"}, {"family": "Onell", "given": "Clara", "initials": "C"}, {"family": "Edlund", "given": "Klara", "initials": "K"}, {"family": "K\u00e4llberg", "given": "Henrik", "initials": "H"}, {"family": "Holm", "given": "Lena W", "initials": "LW"}, {"family": "Sundberg", "given": "Tobias", "initials": "T"}, {"family": "Skillgate", "given": "Eva", "initials": "E"}], "type": "journal article", "published": "2022-06-16", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "1207", "issn-l": null}, "abstract": "Changes in Swedish university students' lifestyle behaviors during the COVID-19 pandemic are unknown. This study aimed to assess physical activity, sitting time, meal frequency and risk substance use (alcohol, tobacco, and illicit use of drugs) in Swedish university students before and during the first six months of the COVID-19 pandemic, for all and stratified by age and sex.\n\nData were obtained from the Sustainable University Life cohort study in which web-based surveys were sent to university students repeatedly for one year. Baseline assessment (before the pandemic) was between August 2019-March 2020, follow-up 1 (FU1) between March-June 2020, and follow-up 2 (FU2) between June-September 2020. Participants reported weekly minutes of physical activity, daily sitting hours, meal frequency by weekly intake of different meals, and motivation for eating irregularly, if so. Also, harmful use of alcohol, tobacco and illicit drugs was assessed. Population means and differences with 95% confidence intervals (95% CI) in lifestyle behaviors between time points were calculated with Generalized Estimating Equations.\n\n1877 students (73% women, mean age 26.5 years) answered the baseline survey. Weekly exercise decreased by -5.7 min (95% CI: -10.0, -1.5) and -7.7 min (95% CI: -12.6, -2.8) between baseline and FU1 and FU2, respectively. Weekly daily activities increased by 5.6 min (95% CI: 0.3, 11.7) and 14.2 min (95% CI: 7.9, 20.5) between baseline and FU1 and FU2. Daily sitting time decreased by -1.4 h (95% CI: -1.7, -1.2) between baseline and FU2. Breakfast intake increased by 0.2 days per week (95% CI: 0.1, 0.3) between baseline and FU2. Lunch intake decreased by -0.2 days per week (95% CI: -0.2, -0.1) between baseline and FU1 and by -0.2 days per week (95% CI: -0.3, -0.0) between baseline and FU2. Dinner intake decreased by -0.1 days per week (95% CI: -0.2, -0.0) between baseline and both FU1 and FU2. Only minor differences in risk substance use were observed. Similar changes were observed in analyses stratified by age and sex.\n\nLifestyle behaviors in Swedish university students slightly improved during the first six months of the COVID-19 pandemic compared to before.\n\nClinicalTrials.gov, NCT04465435 . 10/07/2020.", "doi": "10.1186/s12889-022-13553-7", "pmid": "35710368", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-022-13553-7"}, {"db": "pmc", "key": "PMC9202972"}, {"db": "ClinicalTrials.gov", "key": "NCT04465435"}], "notes": [], "created": "2022-06-20T18:06:39.900Z", "modified": "2022-08-17T12:47:29.378Z"}, {"entity": "publication", "iuid": "cab6d6e06fcb4e34bd7e7ffbb1a41682", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cab6d6e06fcb4e34bd7e7ffbb1a41682.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cab6d6e06fcb4e34bd7e7ffbb1a41682"}}, "title": "High Challenge Exercise and Learning Safe Landing Strategies among Community-Dwelling Older Adults: A Randomized Controlled Trial.", "authors": [{"family": "Arkkukangas", "given": "Marina", "initials": "M", "orcid": "0000-0001-7418-6088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70124d2b28fa4f8f868fb90bc786118d.json"}}, {"family": "Str\u00f6mqvist B\u00e5\u00e5the", "given": "Karin", "initials": "K"}, {"family": "Ekholm", "given": "Anna", "initials": "A"}, {"family": "Tonkonogi", "given": "Michail", "initials": "M"}], "type": "journal article", "published": "2022-06-16", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "12", "issn-l": null}, "abstract": "There is limited research on optimal exercise programs that effectively decrease falls and fall-related injuries in older populations. This randomized controlled trial (RCT) aimed to explore the effects of a 12-week Judo4Balance program on falling techniques, physical and psychological functions, health status, and physical activity levels among 200 community-dwelling older adults (79% women and 21% men) with a mean age of 72 years. The 200 participants were randomly allocated for the Judo4Balce program (n = 100) or control group (n = 100). The RCT intervention started in mid-January 2020 and was abruptly interrupted because of the COVID-19 pandemic. A restart of the RCT was initiated in September 2021, and the 12-week intervention was offered to two groups. This study reports the results from three points of assessment: baseline, 20-month follow-up, and 12-week postintervention. At 20 months follow-up, the control group had significantly decreased physical activity levels (summer p = 0.002 and winter p = 0.003); similar changes were not seen in the exercise group. In the exercise group, learning falling techniques in 6-9 weeks led to sustained fall competence at 20 months follow-up. Further, significant improvements in physical function (exercise group p = 0.009 and control group p &lt; 0.001) and learning falling techniques (p &lt; 0.001 for both groups) were noted in both groups after the 12-week intervention. This effective, supervised, group-based, high-challenge multicomponent exercise program needs to be further evaluated for possible impact on falls and fall-related injuries.", "doi": "10.3390/ijerph19127370", "pmid": "35742618", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19127370"}, {"db": "pmc", "key": "PMC9223480"}], "notes": [], "created": "2022-08-19T05:45:44.848Z", "modified": "2022-08-19T05:45:44.908Z"}, {"entity": "publication", "iuid": "33b737c22915436baa62eeefe8b586aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/33b737c22915436baa62eeefe8b586aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/33b737c22915436baa62eeefe8b586aa"}}, "title": "Private sector engagement in the COVID-19 response: experiences and lessons from the Democratic Republic of Congo, Nigeria, Senegal and Uganda.", "authors": [{"family": "Kabwama", "given": "Steven N", "initials": "SN"}, {"family": "Kiwanuka", "given": "Suzanne N", "initials": "SN"}, {"family": "Mapatano", "given": "Mala Ali", "initials": "MA"}, {"family": "Fawole", "given": "Olufunmilayo I", "initials": "OI"}, {"family": "Seck", "given": "Ibrahima", "initials": "I"}, {"family": "Namale", "given": "Alice", "initials": "A"}, {"family": "Ndejjo", "given": "Rawlance", "initials": "R"}, {"family": "Kizito", "given": "Susan", "initials": "S"}, {"family": "Monje", "given": "Fred", "initials": "F"}, {"family": "Bosonkie", "given": "Marc", "initials": "M"}, {"family": "Egbende", "given": "Landry", "initials": "L"}, {"family": "Bello", "given": "Segun", "initials": "S"}, {"family": "Bamgboye", "given": "Eniola A", "initials": "EA"}, {"family": "Dairo", "given": "Magbagbeola D", "initials": "MD"}, {"family": "Adebowale", "given": "Ayo S", "initials": "AS"}, {"family": "Salawu", "given": "Mobolaji M", "initials": "MM"}, {"family": "Afolabi", "given": "Rotimi F", "initials": "RF"}, {"family": "Diallo", "given": "Issakha", "initials": "I"}, {"family": "Leye", "given": "Mamadou M M", "initials": "MMM"}, {"family": "Ndiaye", "given": "Youssou", "initials": "Y"}, {"family": "Fall", "given": "Mane", "initials": "M"}, {"family": "Bassoum", "given": "Oumar", "initials": "O"}, {"family": "Alfv\u00e9n", "given": "Tobias", "initials": "T"}, {"family": "Sambisa", "given": "William", "initials": "W"}, {"family": "Wanyenze", "given": "Rhoda K", "initials": "RK"}], "type": "journal article", "published": "2022-06-15", "journal": {"title": "Global Health", "issn": "1744-8603", "issn-l": "1744-8603", "volume": "18", "issue": "1", "pages": "60"}, "abstract": "Private entities play a major role in health globally. However, their contribution has not been fully optimized to strengthen delivery of public health services. The COVID-19 pandemic has overwhelmed health systems and precipitated coalitions between public and private sectors to address critical gaps in the response. We conducted a study to document the public and private sector partnerships and engagements to inform current and future responses to public health emergencies.\r\n\r\nThis was a multi-country cross-sectional study conducted in the Democratic Republic of Congo, Nigeria, Senegal and Uganda between November 2020 and March 2021 to assess responses to the COVID-19 pandemic. We conducted a scoping literature review and key informant interviews (KIIs) with private and public health sector stakeholders. The literature reviewed included COVID-19 country guidelines and response plans, program reports and peer-reviewed and non-peer-reviewed publications. KIIs elicited information on country approaches and response strategies specifically the engagement of the private sector in any of the strategic response operations.\r\n\r\nAcross the 4 countries, private sector strengthened laboratory systems, COVID-19 case management, risk communication and health service continuity. In the DRC and Nigeria, private entities supported contact tracing and surveillance activities. Across the 4 countries, the private sector supported expansion of access to COVID-19 testing services through establishing partnerships with the public health sector albeit at unregulated fees. In Senegal and Uganda, governments established partnerships with private sector to manufacture COVID-19 rapid diagnostic tests. The private sector also contributed to treatment and management of COVID-19 cases. In addition, private entities provided personal protective equipment, conducted risk communication to promote adherence to safety procedures and health promotion for health service continuity. However, there were concerns related to reporting, quality and cost of services, calling for quality and price regulation in the provision of services.\r\n\r\nThe private sector contributed to the COVID-19 response through engagement in COVID-19 surveillance and testing, management of COVID-19 cases, and health promotion to maintain health access. There is a need to develop regulatory frameworks for sustainable public-private engagements including regulation of pricing, quality assurance and alignment with national plans and priorities during response to epidemics.", "doi": "10.1186/s12992-022-00853-1", "pmid": "35705961", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12992-022-00853-1"}, {"db": "pmc", "key": "PMC9199342"}], "notes": [], "created": "2022-06-20T18:10:41.041Z", "modified": "2022-08-17T12:58:09.908Z"}, {"entity": "publication", "iuid": "f9435aa3f85149de9a87c626478db9a5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f9435aa3f85149de9a87c626478db9a5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f9435aa3f85149de9a87c626478db9a5"}}, "title": "A prolonged innate systemic immune response in COVID-19.", "authors": [{"family": "Ekstedt", "given": "Sandra", "initials": "S"}, {"family": "Piersiala", "given": "Krzysztof", "initials": "K"}, {"family": "Petro", "given": "Marianne", "initials": "M"}, {"family": "Karlsson", "given": "Agneta", "initials": "A"}, {"family": "K\u00e5gedal", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Kumlien Geor\u00e9n", "given": "Susanna", "initials": "S"}, {"family": "Cardell", "given": "Lars Olaf", "initials": "LO"}], "type": "journal article", "published": "2022-06-15", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "9915", "issn-l": "2045-2322"}, "abstract": "Despite the introduction of vaccines, COVID-19 still affects millions of people worldwide. A better understanding of pathophysiology and the discovery of novel therapies are needed. One of the cells of interest in COVID-19 is the neutrophil. This cell type is being recruited to a site of inflammation as one of the first immune cells. In this project, we investigated a variety of neutrophils phenotypes during COVID-19 by measuring the expression of markers for migration, maturity, activation, gelatinase granules and secondary granules using flow cytometry. We show that neutrophils during COVID-19 exhibit altered phenotypes compared to healthy individuals. The activation level including NETs production and maturity of neutrophils seem to last longer during COVID-19 than expected for innate immunity. Neutrophils as one of the drivers of severe cases of COVID-19 are considered as potential treatment targets. However, for a successful implementation of treatment, there is a need for a better understanding of neutrophil functions and phenotypes in COVID-19. Our study answers some of those questions.", "doi": "10.1038/s41598-022-13986-5", "pmid": "35705573", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-13986-5"}, {"db": "pmc", "key": "PMC9200737"}], "notes": [], "created": "2022-06-20T18:11:26.239Z", "modified": "2022-08-17T12:58:20.345Z"}, {"entity": "publication", "iuid": "87cbba284ec34ff1b0a29296baf8f31a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87cbba284ec34ff1b0a29296baf8f31a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87cbba284ec34ff1b0a29296baf8f31a"}}, "title": "The Every Woman Every Child initiative: supporting countries in Latin America and the Caribbean to reduce social inequalities in health.", "authors": [{"family": "Sanhueza", "given": "Antonio", "initials": "A", "orcid": "0000-0002-1857-3662", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a16398c86edb49bd8bc6c4b70008e040.json"}}, {"family": "Carvajal", "given": "Liliana", "initials": "L", "orcid": "0000-0003-1971-7055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08223ee314804fd897aa13f5e08f7c1d.json"}}, {"family": "Cueva", "given": "Daniel A", "initials": "DA", "orcid": "0000-0002-1871-4680", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be76e4e1e7eb42179379897988af880d.json"}}, {"family": "Caffe", "given": "Sonja", "initials": "S"}, {"family": "Camacho", "given": "Alma Virginia", "initials": "AV"}, {"family": "Berroter\u00e1n", "given": "Mar\u00eda Alejandra", "initials": "MA"}, {"family": "Horowitz", "given": "Deborah", "initials": "D"}, {"family": "Gordillo-Tobar", "given": "Amparo", "initials": "A"}, {"family": "Mujica", "given": "Oscar J", "initials": "OJ", "orcid": "0000-0002-2893-4206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08cf1633e028495ca74ec9513246060b.json"}}, {"family": "Every Woman Every Child Latin America and the Caribbean", "given": "", "initials": ""}], "type": "letter", "published": "2022-06-14", "journal": {"title": "Int J Equity Health", "issn": "1475-9276", "volume": "21", "issue": "1", "pages": "83", "issn-l": null}, "abstract": "The Every Woman Every Child Latin America and the Caribbean (EWEC-LAC) initiative was established in 2017 as a regional inter-agency mechanism. EWEC-LAC coordinates the regional implementation of the Global Strategy for Women's, Children's and Adolescents' Health in Latin America and the Caribbean (LAC), including adaptation to region specific needs, to end preventable deaths, ensure health and well-being and expand enabling environments for the health and well-being of women, children and adolescents. To advance the equitable achievement of these objectives, EWEC-LAC's three working groups collectively support LAC countries in measuring and monitoring social inequalities in health, advocating for their reduction, and designing and implementing equity-oriented strategies, policies and interventions. This support for data-driven advocacy, capacity building, and policy and program solutions toward closing current gaps ensures that no one is left behind. Members of EWEC-LAC include PAHO, UNAIDS, UNFPA, UNICEF, UN WOMEN, the World Bank, the Inter-American Development Bank, USAID, LAC Regional Neonatal Alliance, and the LAC Regional Task Force for the Reduction of Maternal Mortality. To date, EWEC-LAC has developed and collected innovative tools and resources and begun to engage with countries to utilize them to reduce equity gaps. These resources include a framework for the measurement of social inequalities in health, data use and advocacy tools including a data dashboard to visualize trends in social inequalities in health in LAC countries, a methodology for setting targets for the reduction of inequalities, and a compendium of tools, instruments and methods to identify and address social inequalities in health. EWEC-LAC has also engaged regionally to emphasize the importance of recognizing these inequalities at social and political levels, and advocated for the reduction of these gaps. Attention to closing health equity gaps is ever more critical in the face of the COVID-19 pandemic which has exploited existing vulnerabilities. More equitable health systems will be better prepared to confront future health shocks.", "doi": "10.1186/s12939-022-01682-9", "pmid": "35701816", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12939-022-01682-9"}], "notes": [], "created": "2022-06-20T18:15:07.473Z", "modified": "2022-06-20T18:15:29.423Z"}, {"entity": "publication", "iuid": "c2262a7305c24e51974c262e891ff157", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2262a7305c24e51974c262e891ff157.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2262a7305c24e51974c262e891ff157"}}, "title": "Impaired Antibody Response Is Associated with Histone-Release, Organ Dysfunction and Mortality in Critically Ill COVID-19 Patients.", "authors": [{"family": "Lagedal", "given": "Rickard", "initials": "R"}, {"family": "Eriksson", "given": "Oskar", "initials": "O"}, {"family": "S\u00f6rman", "given": "Anna", "initials": "A", "orcid": "0000-0002-1037-1601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7aa6b3c26f634d14be04dc910700ef9f.json"}}, {"family": "Huckriede", "given": "Joram B", "initials": "JB"}, {"family": "Kristensen", "given": "Bjarne", "initials": "B"}, {"family": "Franz\u00e9n", "given": "Stephanie", "initials": "S", "orcid": "0000-0002-5003-2508", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e3799688c8d441fb9f3b62655c75ac26.json"}}, {"family": "Larsson", "given": "Anders", "initials": "A", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2be858ab604743b72383dfdcd14689.json"}}, {"family": "Bergqvist", "given": "Anders", "initials": "A", "orcid": "0000-0002-5789-8777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b0f16ae981064b70adf451e7fb517ab2.json"}}, {"family": "Alving", "given": "Kjell", "initials": "K", "orcid": "0000-0003-0784-0443", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa7365da4fc24c419cedd5d4e3266262.json"}}, {"family": "Forslund", "given": "Anders", "initials": "A"}, {"family": "Persson", "given": "Barbro", "initials": "B"}, {"family": "Ekdahl", "given": "Kristina N", "initials": "KN", "orcid": "0000-0001-7888-1571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a345be186f64a6ea106a3616baec50e.json"}}, {"family": "Garcia de Frutos", "given": "Pablo", "initials": "P", "orcid": "0000-0003-1547-1190", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8aa9ad9840f4838bb74c9eb3aac9658.json"}}, {"family": "Nilsson", "given": "Bo", "initials": "B"}, {"family": "Nicolaes", "given": "Gerry A F", "initials": "GAF"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}], "type": "journal article", "published": "2022-06-14", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "11", "issue": "12", "pages": null}, "abstract": "the pathophysiologic mechanisms explaining differences in clinical outcomes following COVID-19 are not completely described. This study aims to investigate antibody responses in critically ill patients with COVID-19 in relation to inflammation, organ failure and 30-day survival.\r\n\r\nAll patients with PCR-verified COVID-19 and gave consent, and who were admitted to a tertiary Intensive care unit (ICU) in Sweden during March-September 2020 were included. Demography, repeated blood samples and measures of organ function were collected. Analyses of anti-SARS-CoV-2 antibodies (IgM, IgA and IgG) in plasma were performed and correlated to patient outcome and biomarkers of inflammation and organ failure.\r\n\r\nA total of 115 patients (median age 62 years, 77% male) were included prospectively. All patients developed severe respiratory dysfunction, and 59% were treated with invasive ventilation. Thirty-day mortality was 22.6% for all included patients. Patients negative for any anti-SARS-CoV-2 antibody in plasma during ICU admission had higher 30-day mortality compared to patients positive for antibodies. Patients positive for IgM had more ICU-, ventilator-, renal replacement therapy- and vasoactive medication-free days. IgA antibody concentrations correlated negatively with both SAPS3 and maximal SOFA-score and IgM-levels correlated negatively with SAPS3. Patients with antibody levels below the detection limit had higher plasma levels of extracellular histones on day 1 and elevated levels of kidney and cardiac biomarkers, but showed no signs of increased inflammation, complement activation or cytokine release. After adjusting for age, positive IgM and IgG antibodies were still associated with increased 30-day survival, with odds ratio (OR) 7.1 (1.5-34.4) and 4.2 (1.1-15.7), respectively.\r\n\r\nIn patients with severe COVID-19 requiring intensive care, a poor antibody response is associated with organ failure, systemic histone release and increased 30-day mortality.", "doi": "10.3390/jcm11123419", "pmid": "35743491", "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "jcm11123419"}, {"db": "pmc", "key": "PMC9225468"}], "notes": [], "created": "2022-08-19T05:45:15.313Z", "modified": "2022-08-19T12:35:58.860Z"}, {"entity": "publication", "iuid": "f58f8a46b9894a2a99afee5da9ebc9c6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f58f8a46b9894a2a99afee5da9ebc9c6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f58f8a46b9894a2a99afee5da9ebc9c6"}}, "title": "Care home managers' views on the media coverage of COVID-19 outbreaks in care homes for older adults: A case study in Stockholm.", "authors": [{"family": "Morath", "given": "Lenke P", "initials": "LP"}, {"family": "Burstr\u00f6m", "given": "Bo", "initials": "B"}, {"family": "Liljas", "given": "Ann E M", "initials": "AEM", "orcid": "0000-0002-2358-6046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/669cff9e8a5b4042bd0019b7bd92d162.json"}}], "type": "journal article", "published": "2022-06-14", "journal": {"title": "Int J Older People Nurs", "issn": "1748-3743", "pages": "e12483", "issn-l": null}, "abstract": "The COVID-19 pandemic has particularly affected older adults and resulted in high rates of infections and deaths in care homes. We have conducted a case study in which three managers of care homes for older adults in central Stockholm have shared their thoughts on the media coverage of care homes for older adults during the COVID-19 pandemic. We analysed the data using conventional content analysis and identified three themes and five categories. The results show that the managers experienced the media coverage of care homes during the pandemic to be negative and incomplete, causing feelings of sadness and shame amongst themselves and their staff. The negative media coverage further generated added workload as they had to arrange for discussions to answer questions by staff and close relatives of the residents. Informants also thought that there is a lack of knowledge about the role of care homes and subsequently what to expect of them. Finally, informants reported that the pandemic might create an opportunity for system-level policy changes. In light of this, we discuss possible victim blaming of staff and how greater public awareness of the care home sector could facilitate for a debate on policy changes and the low social status of caring for older adults.", "doi": "10.1111/opn.12483", "pmid": "35699305", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9350000"}], "notes": [], "created": "2022-06-20T18:16:23.183Z", "modified": "2022-08-17T13:02:38.833Z"}, {"entity": "publication", "iuid": "51b7cb22b9794702a310bb4b49798ee4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/51b7cb22b9794702a310bb4b49798ee4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/51b7cb22b9794702a310bb4b49798ee4"}}, "title": "COVID-19 outcomes in haematopoietic cell transplant recipients: A systematic review and meta-analysis.", "authors": [{"family": "Lim", "given": "Yeong Jer", "initials": "YJ", "orcid": "0000-0002-9022-2904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8c08d684e83431b99d44a7a612b6325.json"}}, {"family": "Khan", "given": "Umair", "initials": "U"}, {"family": "Karpha", "given": "Indrani", "initials": "I"}, {"family": "Ross", "given": "Andrew", "initials": "A"}, {"family": "Saif", "given": "Muhammad", "initials": "M"}, {"family": "Remberger", "given": "Mats", "initials": "M"}, {"family": "Kalakonda", "given": "Nagesh", "initials": "N"}, {"family": "Pettitt", "given": "Andrew R", "initials": "AR"}, {"family": "Floisand", "given": "Yngvar", "initials": "Y"}], "type": "journal article", "published": "2022-06-14", "journal": {"title": "EJHaem", "issn": "2688-6146", "issn-l": null}, "abstract": "Up-to-date information on coronavirus disease 2019 (COVID-19) outcomes and risk factors in haematopoietic cell transplantation (HCT) recipients is required to inform on decisions about cancer treatment and COVID-19 mitigation strategies. We performed a meta-analysis to address this knowledge gap. All studies with at least five patients who reported COVID-19-related deaths in HCT recipients were included. The primary outcome was COVID-19-related death. Secondary outcomes were COVID-19-related mechanical ventilation (MV) and intensive care unit (ITU) admission. The cumulative COVID-19-related death rate among HCT recipients was 21% (95% confidence interval [CI] 18%-24%), while MV and ITU admission rates were 14% (95% CI 11%-17%) and 18% (95% CI 14%-22%), respectively. Subgroup analysis showed higher death rates in patients who developed COVID-19 within 12 months of HCT (risk ratio [RR] 1.82, 95% CI 1.09-3.03), within 6 months of receiving immunosuppressant drugs (RR 2.11, 95% CI 1.38-3.20) or in the context of active graft-versus-host disease (RR 2.38, 95% CI 1.10-5.16). Our findings support the idea that HCT should remain an integral part of cancer treatment during the COVID-19 pandemic but also highlight the need to prioritise preventative measures in those patients who are at increased risk of adverse COVID-19 outcomes.", "doi": "10.1002/jha2.465", "pmid": "35941880", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "JHA2465"}, {"db": "pmc", "key": "PMC9350043"}], "notes": [], "created": "2022-08-11T11:51:25.952Z", "modified": "2022-08-11T11:51:56.016Z"}, {"entity": "publication", "iuid": "c9f0e8da00d74515a863b2bed87412d1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9f0e8da00d74515a863b2bed87412d1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9f0e8da00d74515a863b2bed87412d1"}}, "title": "Athletes' Mesenchymal Stem Cells Could Be the Best Choice for Cell Therapy in Omicron-Infected Patients.", "authors": [{"family": "Saheli", "given": "Mona", "initials": "M"}, {"family": "Khoramipour", "given": "Kayvan", "initials": "K"}, {"family": "Vosough", "given": "Massoud", "initials": "M", "orcid": "0000-0001-5924-4366", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bf15c1fec524a79b8801694434587e3.json"}}, {"family": "Piryaei", "given": "Abbas", "initials": "A", "orcid": "0000-0002-3182-6214", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1807b026f88d4af8837f34b8d313843f.json"}}, {"family": "Rahmati", "given": "Masoud", "initials": "M", "orcid": "0000-0003-4792-027X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b5fa1a704f045eb97ff31ce02591801.json"}}, {"family": "Suzuki", "given": "Katsuhiko", "initials": "K", "orcid": "0000-0002-6572-5809", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00c6d85718554e2b9fd967bc69514508.json"}}], "type": "journal article", "published": "2022-06-14", "journal": {"title": "Cells", "issn": "2073-4409", "volume": "11", "issue": "12", "issn-l": null}, "abstract": "New severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, Omicron, contains 32 mutations that have caused a high incidence of breakthrough infections or re-infections. These mutations have reduced vaccine protection against Omicron and other new emerging variants. This highlights the need to find effective treatment, which is suggested to be stem cell-based therapy. Stem cells could support respiratory epithelial cells and they could restore alveolar bioenergetics. In addition, they can increase the secretion of immunomodulatory cytokines. However, after transplantation, cell survival and growth rate are low because of an inappropriate microenvironment, and stem cells face ischemia, inflammation, and oxidative stress in the transplantation niche which reduces the cells' survival and growth. Exercise-training can upregulate antioxidant, anti-inflammatory, and anti-apoptotic defense mechanisms and increase growth signaling, thereby improving transplanted cells' survival and growth. Hence, using athletes' stem cells may increase stem-cell therapy outcomes in Omicron-affected patients.", "doi": "10.3390/cells11121926", "pmid": "35741055", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "cells11121926"}, {"db": "pmc", "key": "PMC9221912"}], "notes": [], "created": "2022-08-19T05:48:12.702Z", "modified": "2022-08-19T05:48:12.833Z"}, {"entity": "publication", "iuid": "7cb12a386d7c47e4b404b7d606141ad1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7cb12a386d7c47e4b404b7d606141ad1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7cb12a386d7c47e4b404b7d606141ad1"}}, "title": "Olfactory distortions in the general population.", "authors": [{"family": "Olofsson", "given": "Jonas K", "initials": "JK"}, {"family": "Ekesten", "given": "Fredrik", "initials": "F"}, {"family": "Nordin", "given": "Steven", "initials": "S"}], "type": "journal article", "published": "2022-06-13", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "9776", "issn-l": "2045-2322"}, "abstract": "Parosmia, distorted smell sensations, is a common consequence of respiratory virus infections. The phenomenon is not well understood in terms of its impact and long-term outcomes. We examined self-reported experiences of parosmia in a population-based sample from the Betula study that was conducted in Ume\u00e5 in northern Sweden (baseline data collected in 1998-2000). We used a baseline sample of 2168 individuals aged 35-90 years and with no cognitive impairment at baseline. We investigated the prevalence of parosmia experiences and, using regression analyses, its relationship to other olfactory and cognitive variables and quality of life. Benefitting from the longitudinal study design, we also assessed the persistence of parosmia over 5 and 10 years prospectively. Parosmia experiences were prevalent in 4.8% of the population and it often co-occurred with phantosmia (\"olfactory hallucinations\"), but was not associated with lower self-rated overall quality of life or poor performance on olfactory or cognitive tests. For some individuals, parosmia was retained 5 years (17.0%) or even 10 years later (10.3%). Thus, parosmia experiences are commonly reported in the population, and can be persistent for some individuals, but might be mostly benign in nature. Our work complements research on clinical-level parosmia, which is typically more severe, and recent parosmia reports during the COVID-19 pandemic, where long-term outcomes are still unknown.", "doi": "10.1038/s41598-022-13201-5", "pmid": "35697904", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-13201-5"}], "notes": [], "created": "2022-06-20T18:18:24.318Z", "modified": "2022-06-20T18:18:24.332Z"}, {"entity": "publication", "iuid": "f461eb0c2e0f4a5cb43861847a056bfa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f461eb0c2e0f4a5cb43861847a056bfa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f461eb0c2e0f4a5cb43861847a056bfa"}}, "title": "Influence on study outcomes of an inpatient study by the behavior of the study staff (PINgPOng): study protocol for a randomized clinical trial.", "authors": [{"family": "Coenen", "given": "Martin", "initials": "M", "orcid": "0000-0003-0439-4409", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5bf4db2156e4f24b3ffcd88a024da9a.json"}}, {"family": "Bingel", "given": "Ulrike", "initials": "U"}, {"family": "Zunhammer", "given": "Matthias", "initials": "M"}, {"family": "Berdaguer", "given": "Maria Soledad", "initials": "MS"}, {"family": "Fuhrmann", "given": "Christine", "initials": "C"}, {"family": "Fimmers", "given": "Rolf", "initials": "R"}, {"family": "Rengelshausen", "given": "Jens", "initials": "J"}, {"family": "Hartmann", "given": "Gunther", "initials": "G"}, {"family": "Schedlowski", "given": "Manfred", "initials": "M"}, {"family": "Coch", "given": "Christoph", "initials": "C"}], "type": "clinical trial protocol", "published": "2022-06-13", "journal": {"title": "Trials", "issn": "1745-6215", "volume": "23", "issue": "1", "pages": "488", "issn-l": null}, "abstract": "The placebo effect as the symptom improvement following inert treatments is a fixed component of RCTs to differentiate between specific effects of the tested pharmacological substance from other unspecific effects. The PINgPOng study was set up to analyze the influence of a study team trained to either minimize the placebo response and optimize drug-placebo differences or to maximize the placebo response to increase drug efficacy by unspecific factors on the study results of a RCT in a classical early clinical trial setting.\n\nPINgPOng is a single-center, prospective, randomized, double-blind, placebo-controlled study in a 3-group, 2-sequence, 2-period cross-over design. The study is conducted according to the principles of ICH-GCP and the Declaration of Helsinki on the Phase I-Unit of the University Hospital Bonn. The primary endpoint is the pain intensity in the cold pressor test before and after the administration of 15 mg oxycodone or placebo. The pain intensity is compared between three study conditions: 32 healthy volunteers in each study arm will be treated either by an untrained study team (arm A), by a study team trained to maximize (arm B), or to minimize placebo responses (arm C). Neuroendocrine factors (alpha-amylase activity, salivary cortisol), characteristic traits (anxiety, depression, stress), and somatic reactions are analyzed as covariates of the pain perception.\n\nThe PINgPOng study will allow to answer the question whether and to what extent the behavior of a trained study team (neutral vs. maximize vs. minimize placebo responses) will differentially affect placebo responses in a setting of a highly standardized early clinical trial. The results will help to control the placebo effects by education of the clinical study team and to avoid unnecessary high placebo effects in clinical development.\n\nGerman Clinical Trials Register DRKS00013586 . Registered on December 22, 2017.", "doi": "10.1186/s13063-022-06436-0", "pmid": "35698101", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13063-022-06436-0"}], "notes": [], "created": "2022-06-20T18:18:10.247Z", "modified": "2022-06-20T18:18:10.298Z"}, {"entity": "publication", "iuid": "2ab7837ec8724d3f8643dda0d357dc01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ab7837ec8724d3f8643dda0d357dc01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ab7837ec8724d3f8643dda0d357dc01"}}, "title": "Factors Associated With the Decay of Anti-SARS-CoV-2 S1 IgG Antibodies Among Recipients of an Adenoviral Vector-Based AZD1222 and a Whole-Virion Inactivated BBV152 Vaccine.", "authors": [{"family": "Selvavinayagam", "given": "Sivaprakasam T", "initials": "ST"}, {"family": "Yong", "given": "Yean Kong", "initials": "YK"}, {"family": "Tan", "given": "Hong Yien", "initials": "HY"}, {"family": "Zhang", "given": "Ying", "initials": "Y"}, {"family": "Subramanian", "given": "Gurunathan", "initials": "G"}, {"family": "Rajeshkumar", "given": "Manivannan", "initials": "M"}, {"family": "Vasudevan", "given": "Kalaivani", "initials": "K"}, {"family": "Jayapal", "given": "Priyanka", "initials": "P"}, {"family": "Narayanasamy", "given": "Krishnasamy", "initials": "K"}, {"family": "Ramesh", "given": "Dinesh", "initials": "D"}, {"family": "Palani", "given": "Sampath", "initials": "S"}, {"family": "Larsson", "given": "Marie", "initials": "M"}, {"family": "Shankar", "given": "Esaki M", "initials": "EM"}, {"family": "Raju", "given": "Sivadoss", "initials": "S"}], "type": "journal article", "published": "2022-06-13", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "9", "pages": "887974", "issn-l": null}, "abstract": "The magnitude of protection conferred following recovery from COVID-19 or by vaccine administration, and the duration of protective immunity developed, remains ambiguous.\n\nWe investigated the factors associated with anti-SARS-CoV-2 S1 IgG decay in 519 individuals who recovered from COVID-19 illness or received COVID-19 vaccination with two commercial vaccines, viz., an adenoviral vector-based (AZD1222) and a whole-virion-based inactivated (BBV152) vaccine in Chennai, India from March to December 2021. Blood samples collected during regular follow-up post-infection/-vaccination were examined for anti-SARS-CoV-2 S1 IgG by a commercial automated chemiluminescent immunoassay (CLIA).\n\nAge and underlying comorbidities were the two variables that were independently associated with the development of a breakthrough infection. Individuals who were >60 years of age with underlying comorbid conditions (viz., hypertension, diabetes mellitus and cardiovascular disease) had a ~15 times and ~10 times greater odds for developing a breakthrough infection and hospitalization, respectively. The time elapsed since the first booster dose was associated with attrition in anti-SARS-CoV-2 IgG, where each month passed was associated with an ebb in the anti-SARS-CoV-2 IgG antibody levels by a coefficient of -6 units.\n\nOur findings advocate that the elderly with underlying comorbidities be administered with appropriate number of booster doses with AZD1222 and BBV152 against COVID-19.", "doi": "10.3389/fmed.2022.887974", "pmid": "35770011", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9235407"}], "notes": [], "created": "2022-08-19T05:32:02.750Z", "modified": "2023-06-19T15:34:18.898Z"}, {"entity": "publication", "iuid": "1f548fe422a845ef8b31a29baa318722", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1f548fe422a845ef8b31a29baa318722.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1f548fe422a845ef8b31a29baa318722"}}, "title": "Compliance of healthcare workers with the infection prevention and control guidance in tertiary care hospitals: quantitative findings from an explanatory sequential mixed-methods study in Bangladesh.", "authors": [{"family": "Salwa", "given": "Marium", "initials": "M", "orcid": "0000-0001-7869-3343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc49c7c98d32429387b54911fb024274.json"}}, {"family": "Haque", "given": "M Atiqul", "initials": "MA"}, {"family": "Islam", "given": "Syed Shariful", "initials": "SS"}, {"family": "Islam", "given": "Mohammad Tanvir", "initials": "MT"}, {"family": "Sultana", "given": "Sarmin", "initials": "S"}, {"family": "Khan", "given": "Md Maruf Haque", "initials": "MMH"}, {"family": "Moniruzzaman", "given": "Syed", "initials": "S"}], "type": "journal article", "published": "2022-06-13", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "6", "pages": "e054837", "issn-l": "2044-6055"}, "abstract": "To assess healthcare workers' (HCWs) compliance with the infection prevention and control (IPC) practices and identify the factors influencing this compliance using the Health Belief Model as the theoretical framework.\n\nQuantitative data from an explanatory sequential mixed-methods study were employed in this research.\n\nFrom 17 May to 30 August 2020, 604 physicians and nurses working at six randomly selected tertiary care facilities in Dhaka City in Bangladesh took part in this study.\n\nCompliance with the WHO's guidance on IPC measures, as well as the associated factors, was the primary outcome.\n\nA mean compliance score of 0.49 (\u00b10.25) was observed on a 0-1 scale. HCWs were most compliant with the medical mask wearing guidelines (81%) and were least compliant with the high-touch surface decontamination regulations (23%). Compliance with the IPC guidance was significantly associated with increasing age, female sex, working as a nurse, having non-communicable diseases and history of exposure to patients with COVID-19. Perceived benefits (B=0.039, 95% CI 0.001 to 0.076), self-efficacy (B=0.101, 95% CI 0.060 to 0.142) and cues to action (B=0.045, 95% CI 0.002 to 0.088) were positively associated with compliance. Compliance with IPC guidance was 0.061 times greater among participants who reported low perceived barriers compared with those with high perceived barriers.\n\nOverall, compliance with IPC guidance among HCWs was unsatisfactory. As self-efficacy exerted the greatest contribution to compliance, it should be emphasised in any endeavour to improve HCWs' IPC adherence. Such interventions should also focus on perceived barriers, including unreliability of the information sources, unsafe working places and unavailability of protective equipment and cues to action, including trust in the administration and availability of adequate IPC guidance.", "doi": "10.1136/bmjopen-2021-054837", "pmid": "35697439", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-054837"}], "notes": [], "created": "2022-06-20T18:18:49.066Z", "modified": "2022-06-20T18:18:49.122Z"}, {"entity": "publication", "iuid": "123bc7ea77f849f0ade0b6b2b402043a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/123bc7ea77f849f0ade0b6b2b402043a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/123bc7ea77f849f0ade0b6b2b402043a"}}, "title": "Cohort Profile: COVIDMENT: COVID-19 cohorts on mental health across six nations.", "authors": [{"family": "Unnarsd\u00f3ttir", "given": "Anna B\u00e1ra", "initials": "AB", "orcid": "0000-0002-6421-445X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2da21ebd675c4e329c47bf64bbc1578a.json"}}, {"family": "Lovik", "given": "Anik\u00f3", "initials": "A"}, {"family": "Fawns-Ritchie", "given": "Chloe", "initials": "C"}, {"family": "Ask", "given": "Helga", "initials": "H"}, {"family": "K\u00f5iv", "given": "Kadri", "initials": "K"}, {"family": "Hagen", "given": "Kristen", "initials": "K"}, {"family": "Didriksen", "given": "Maria", "initials": "M", "orcid": "0000-0002-4856-496X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b0efe911882405c9d53fd4a49797d07.json"}}, {"family": "Christoffersen", "given": "Lea Arregui Nordahl", "initials": "LAN"}, {"family": "Gar\u00f0arsson", "given": "Alexander Berg", "initials": "AB"}, {"family": "McIntosh", "given": "Andrew", "initials": "A"}, {"family": "K\u00e4hler", "given": "Anna K", "initials": "AK"}, {"family": "Campbell", "given": "Archie", "initials": "A", "orcid": "0000-0003-0198-5078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e2c09aef9a6458e857d323d5447423d.json"}}, {"family": "Hauksd\u00f3ttir", "given": "Arna", "initials": "A"}, {"family": "Erikstrup", "given": "Christian", "initials": "C", "orcid": "0000-0001-6551-6647", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f01382b51d3e46d8b8c9d74dbed3ce81.json"}}, {"family": "Mikkelsen", "given": "Dorte Helenius", "initials": "DH"}, {"family": "Altschul", "given": "Drew", "initials": "D", "orcid": "0000-0001-7053-4209", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a158612fcea406284cb809b0e9eb6ac.json"}}, {"family": "Thordardottir", "given": "Edda Bjork", "initials": "EB"}, {"family": "Frans", "given": "Emma Maria", "initials": "EM"}, {"family": "Kvale", "given": "Gerd", "initials": "G"}, {"family": "T\u00f3masson", "given": "Gunnar", "initials": "G"}, {"family": "Kariis", "given": "Hanna Maria", "initials": "HM"}, {"family": "J\u00f3nsd\u00f3ttir", "given": "Harpa Lind", "initials": "HL"}, {"family": "R\u00fanarsd\u00f3ttir", "given": "Harpa", "initials": "H"}, {"family": "Magn\u00fasd\u00f3ttir", "given": "Ingibj\u00f6rg", "initials": "I"}, {"family": "Eid", "given": "Jarle", "initials": "J"}, {"family": "Jakobsd\u00f3ttir", "given": "J\u00f3hanna", "initials": "J"}, {"family": "Nielsen", "given": "Kaspar Ren\u00e9", "initials": "KR"}, {"family": "Kaspersen", "given": "Kathrine Agerg\u00e5rd", "initials": "KA"}, {"family": "Milani", "given": "Lili", "initials": "L"}, {"family": "Trogstad", "given": "Lill-Iren Schou", "initials": "LS"}, {"family": "Yi", "given": "Lu", "initials": "L"}, {"family": "Bruun", "given": "Mie Topholm", "initials": "MT"}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF"}, {"family": "Magnus", "given": "Per Minor", "initials": "PM"}, {"family": "Shen", "given": "Qing", "initials": "Q", "orcid": "0000-0002-7214-4797", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/940144ccf8434a33a287ed4ff191be8d.json"}}, {"family": "Nesv\u00e5g", "given": "Ragnar", "initials": "R"}, {"family": "Brandlistuen", "given": "Ragnhild E", "initials": "RE", "orcid": "0000-0001-8054-0960", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/95d019cbc4714bc28863d5e26db63b1a.json"}}, {"family": "M\u00e4gi", "given": "Reedik", "initials": "R"}, {"family": "Ostrowski", "given": "Sisse Rye", "initials": "SR"}, {"family": "L\u00f8khammer", "given": "Solveig", "initials": "S"}, {"family": "Solem", "given": "Stian", "initials": "S"}, {"family": "Reichborn-Kjennerud", "given": "Ted", "initials": "T"}, {"family": "Hansen", "given": "Thomas Folkmann", "initials": "TF"}, {"family": "Werge", "given": "Thomas", "initials": "T"}, {"family": "Aspelund", "given": "Thor", "initials": "T", "orcid": "0000-0002-7998-5433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f3b5030190743e4b0ec0be05afb8fa8.json"}}, {"family": "Porteous", "given": "David J", "initials": "DJ"}, {"family": "Fang", "given": "Fang", "initials": "F", "orcid": "0000-0002-3310-6456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b0852465cd14239a25329b976172792.json"}}, {"family": "Lehto", "given": "Kelli", "initials": "K"}, {"family": "Andreassen", "given": "Ole A", "initials": "OA"}, {"family": "Pedersen", "given": "Ole Birger Vesterager", "initials": "OBV"}, {"family": "Hellard", "given": "Stephanie Le", "initials": "SL"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}], "type": "journal article", "published": "2022-06-13", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "volume": "51", "issue": "3", "pages": "e108-e122", "issn-l": "0300-5771"}, "abstract": null, "doi": "10.1093/ije/dyab234", "pmid": "35020900", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8690101"}, {"db": "pii", "key": "6432503"}], "notes": [], "created": "2022-01-13T20:55:36.883Z", "modified": "2023-02-13T18:37:59.354Z"}, {"entity": "publication", "iuid": "c1e7d453c52d48b7bdcca526b7537a96", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1e7d453c52d48b7bdcca526b7537a96.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1e7d453c52d48b7bdcca526b7537a96"}}, "title": "A retrospective cohort study of the effect of SARS-CoV-2 point of care rapid RT-PCR at the Emergency Department on targeted admission.", "authors": [{"family": "Mortazavi", "given": "Susanne E", "initials": "SE"}, {"family": "Inghammar", "given": "Malin", "initials": "M"}, {"family": "Christiansen", "given": "Claus", "initials": "C"}, {"family": "Pesola", "given": "Anne-Katrine", "initials": "AK"}, {"family": "Stenkilsson", "given": "Mikael", "initials": "M"}, {"family": "Paulsson", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1104-2727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0e37d2d03f64fe78a0e84f53922d29f.json"}}], "type": "journal article", "published": "2022-06-13", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "volume": "22", "issue": "1", "pages": "536", "issn-l": null}, "abstract": "To prevent nosocomial transmission of SARS-CoV-2, infection prevention control (IPC) measures are implemented for patients with symptoms compatible with COVID-19 until reliable test results are available. This delays admission to the most appropriate ward based on the medical condition. SARS-CoV-2 rapid antigen detection (RAD) tests and point-of-care (POC) rapid RT-PCR (VitaPCR) were introduced at emergency department (ED) at Sk\u00e5ne University Hospital, Sweden in late 2020, but the consequence on patient flow and targeted admission is unknown.\n\nPatients presenting at the emergency department of a referral hospital (N = 2940) between 13-Nov-2020 and 12-Jan-2021 were included. The study period was delimited into three periods by the introduction of RAD tests and the VitaPCR. Participant data was collected from hospital records, and outcome variables were Length-of-Stay (LoS), intrahospital transfers and targeted admission to COVID-19 ward.\n\nCompared to baseline (RT-PCR only), RAD tests reduced ED Length-of-Stay (LoS) for participants with positive tests. Negative VitaPCR results reduced mean hospital LoS by 1.5 (95% CI 0.3-2.7) days and admissions to COVID-19 wards from 34.5 (95% CI 28.9-40.5) to 14.7 (95% CI 11.1-19.1) per 100 admissions and reduced transfers between hospital wards in the first 5 days from 50.0 (95% CI 45.0-55.0) to 34.0 (95% CI 30.3-37.9) per 100 admissions.\n\nRAD tests enabled prompt detection of SARS-CoV-2 infection which had pronounced effects on LoS at the ED. Negative VitaPCR enabled cessation of IPC measures and a negative test was associated with increased targeted admissions, reduced intrahospital transfers and shorter LoS at the hospital.", "doi": "10.1186/s12879-022-07497-x", "pmid": "35692041", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12879-022-07497-x"}], "notes": [], "created": "2022-06-20T18:21:13.398Z", "modified": "2022-06-20T18:21:13.445Z"}, {"entity": "publication", "iuid": "6ae19140f6104a0983b7bb365708ad21", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ae19140f6104a0983b7bb365708ad21.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ae19140f6104a0983b7bb365708ad21"}}, "title": "aMMP-8 Oral Fluid PoC Test in Relation to Oral and Systemic Diseases.", "authors": [{"family": "Sorsa", "given": "Timo", "initials": "T"}, {"family": "Nwhator", "given": "Solomon Olusegun", "initials": "SO"}, {"family": "Sakellari", "given": "Dimitra", "initials": "D"}, {"family": "Grigoriadis", "given": "Andreas", "initials": "A"}, {"family": "Umeizudike", "given": "Kehinde Adesola", "initials": "KA"}, {"family": "Brandt", "given": "Ella", "initials": "E"}, {"family": "Keskin", "given": "Mutlu", "initials": "M"}, {"family": "Tervahartiala", "given": "Taina", "initials": "T"}, {"family": "P\u00e4rn\u00e4nen", "given": "Pirjo", "initials": "P"}, {"family": "Gupta", "given": "Shipra", "initials": "S"}, {"family": "Mohindra", "given": "Ritin", "initials": "R"}, {"family": "Bostanci", "given": "Nagihan", "initials": "N"}, {"family": "Buduneli", "given": "Nurcan", "initials": "N"}, {"family": "R\u00e4is\u00e4nen", "given": "Ismo Tapani", "initials": "IT"}], "type": "journal article", "published": "2022-06-10", "journal": {"title": "Front Oral Health", "issn": "2673-4842", "volume": "3", "pages": "897115", "issn-l": null}, "abstract": "The manuscript uses the previously published literature and highlights the benefits of active-matrix metalloproteinase (aMMP)-8 chairside/point-of-care (PoC) diagnostic tools as adjunctive measures in oral and systemic diseases. Previous studies suggest that as a biomarker, aMMP-8 is more precise than total MMP-8, MMP-9, MMP-2, MMP-3, MMP-13, MMP-7, MMP-1, calprotectin, myeloperoxidase (MPO), human neutrophil elastase (HNE), tissue inhibitor of matrix metalloproteinase (TIMP)-1, and bleeding of probing (BOP). Therefore, aMMP-8 could be implemented as the needed key biomarker for the new disease classification for both periodontitis and peri-implantitis. With a sensitivity to the tune of 75-85% and specificity in the range of 80-90%, lateral flow aMMP-8 PoC testing is comparable to catalytic protease activity assays for aMMP-8. The test can be further applied to estimate the glycemic status of an individual, to ascertain whether a person is at risk for COVID-19, in managing the oral side effects of radiotherapy carried in head and neck cancers, and in selected cases pertaining to reproductive health. In the future, aMMP-8 could find application as a potential systemic biomarker in diseases affecting the cardiovascular system, cancers, bacteremia, sepsis, diabetes, obesity, meningitis, as well as pancreatitis. The aMMP-8 PoCT is the first practical test in the emerging new dental clinical field, that is, oral clinical chemistry representing oral medicine, clinical chemistry, peri-implantology, and periodontology.", "doi": "10.3389/froh.2022.897115", "pmid": "35757444", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC9226345"}], "notes": [], "created": "2022-08-19T05:38:03.867Z", "modified": "2022-08-19T05:38:03.904Z"}, {"entity": "publication", "iuid": "55689f4f9c6540d888c7715314d2a70d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/55689f4f9c6540d888c7715314d2a70d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/55689f4f9c6540d888c7715314d2a70d"}}, "title": "Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination.", "authors": [{"family": "Scutelnic", "given": "Adrian", "initials": "A", "orcid": "0000-0001-9053-584X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c03804e51e6434382ecafddecb77bf0.json"}}, {"family": "Krzywicka", "given": "Katarzyna", "initials": "K"}, {"family": "Mbroh", "given": "Joshua", "initials": "J", "orcid": "0000-0002-0108-9161", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44e989b3250f44ba8d76c9998461cea2.json"}}, {"family": "van de Munckhof", "given": "Anita", "initials": "A"}, {"family": "S\u00e1nchez van Kammen", "given": "Mayte", "initials": "M", "orcid": "0000-0001-5614-9689", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae4f548088eb4c099837e35267755c0b.json"}}, {"family": "Aguiar de Sousa", "given": "Diana", "initials": "D"}, {"family": "Lindgren", "given": "Erik", "initials": "E", "orcid": "0000-0002-7628-5044", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e973b3c74ff4e5cba42da605a13bc61.json"}}, {"family": "Jood", "given": "Katarina", "initials": "K"}, {"family": "G\u00fcnther", "given": "Albrecht", "initials": "A"}, {"family": "Hiltunen", "given": "Sini", "initials": "S"}, {"family": "Putaala", "given": "Jukka", "initials": "J", "orcid": "0000-0002-6630-6104", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1930f3c097044b3a00d888744dab332.json"}}, {"family": "Tiede", "given": "Andreas", "initials": "A"}, {"family": "Maier", "given": "Frank", "initials": "F"}, {"family": "Kern", "given": "Rolf", "initials": "R"}, {"family": "Bartsch", "given": "Thorsten", "initials": "T"}, {"family": "Althaus", "given": "Katharina", "initials": "K"}, {"family": "Ciccone", "given": "Alfonso", "initials": "A"}, {"family": "Wiedmann", "given": "Markus", "initials": "M"}, {"family": "Skjelland", "given": "Mona", "initials": "M"}, {"family": "Medina", "given": "Antonio", "initials": "A"}, {"family": "Cuadrado-Godia", "given": "Elisa", "initials": "E"}, {"family": "Cox", "given": "Thomas", "initials": "T"}, {"family": "Aujayeb", "given": "Avinash", "initials": "A"}, {"family": "Raposo", "given": "Nicolas", "initials": "N", "orcid": "0000-0002-9152-4445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e10b5314fc94454b9c9c93eda229c6ff.json"}}, {"family": "Garambois", "given": "Katia", "initials": "K"}, {"family": "Payen", "given": "Jean-Francois", "initials": "JF"}, {"family": "Vuillier", "given": "Fabrice", "initials": "F"}, {"family": "Franchineau", "given": "Guillaume", "initials": "G"}, {"family": "Timsit", "given": "Serge", "initials": "S", "orcid": "0000-0003-0346-8576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7082d2f62ee47dd930342533b8841cf.json"}}, {"family": "Bougon", "given": "David", "initials": "D"}, {"family": "Dubois", "given": "Marie-C\u00e9cile", "initials": "MC"}, {"family": "Tawa", "given": "Audrey", "initials": "A"}, {"family": "Tracol", "given": "Clement", "initials": "C"}, {"family": "De Maistre", "given": "Emmanuel", "initials": "E"}, {"family": "Bonneville", "given": "Fabrice", "initials": "F"}, {"family": "Vayne", "given": "Caroline", "initials": "C"}, {"family": "Mengel", "given": "Annerose", "initials": "A"}, {"family": "Michalski", "given": "Dominik", "initials": "D"}, {"family": "Pelz", "given": "Johann", "initials": "J"}, {"family": "Wittstock", "given": "Matthias", "initials": "M"}, {"family": "Bode", "given": "Felix", "initials": "F"}, {"family": "Zimmermann", "given": "Julian", "initials": "J"}, {"family": "Schouten", "given": "Judith", "initials": "J"}, {"family": "Buture", "given": "Alina", "initials": "A"}, {"family": "Murphy", "given": "Sean", "initials": "S"}, {"family": "Palma", "given": "Vincenzo", "initials": "V", "orcid": "0000-0002-5178-7793", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/917551b107984115bd6544b5079a56d1.json"}}, {"family": "Negro", "given": "Alberto", "initials": "A"}, {"family": "Gutschalk", "given": "Alexander", "initials": "A"}, {"family": "Nagel", "given": "Simon", "initials": "S"}, {"family": "Schoenenberger", "given": "Silvia", "initials": "S", "orcid": "0000-0002-3348-6719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d55b87b9e7b94c0e936017c09d2f4113.json"}}, {"family": "Frisullo", "given": "Giovanni", "initials": "G"}, {"family": "Zanferrari", "given": "Carla", "initials": "C"}, {"family": "Grillo", "given": "Francesco", "initials": "F"}, {"family": "Giammello", "given": "Fabrizio", "initials": "F", "orcid": "0000-0002-2828-1305", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15fc1c416e354e57aa7e27beca2c5288.json"}}, {"family": "Martin", "given": "Mar Morin", "initials": "MM"}, {"family": "Cervera", "given": "Alvaro", "initials": "A"}, {"family": "Burrow", "given": "Jim", "initials": "J"}, {"family": "Garcia Esperon", "given": "Carlos", "initials": "C", "orcid": "0000-0001-8843-5890", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09472127f9334b0683793dd810154088.json"}}, {"family": "Chew", "given": "Beng Lim Alvin", "initials": "BLA"}, {"family": "Kleinig", "given": "Timothy J", "initials": "TJ"}, {"family": "Soriano", "given": "Cristina", "initials": "C"}, {"family": "Zimatore", "given": "Domenico S", "initials": "DS"}, {"family": "Petruzzellis", "given": "Marco", "initials": "M"}, {"family": "Elkady", "given": "Ahmed", "initials": "A"}, {"family": "Miranda", "given": "Miguel S", "initials": "MS"}, {"family": "Fernandes", "given": "Jo\u00e3o", "initials": "J"}, {"family": "Hellstr\u00f6m Vogel", "given": "\u00c5sl\u00f6g", "initials": "\u00c5"}, {"family": "Johansson", "given": "Elias", "initials": "E"}, {"family": "Philip", "given": "Anemon Puthuppallil", "initials": "AP"}, {"family": "Coutts", "given": "Shelagh B", "initials": "SB"}, {"family": "Bal", "given": "Simerpreet", "initials": "S"}, {"family": "Buck", "given": "Brian", "initials": "B"}, {"family": "Legault", "given": "Catherine", "initials": "C"}, {"family": "Blacquiere", "given": "Dylan", "initials": "D"}, {"family": "Katzberg", "given": "Hans D", "initials": "HD"}, {"family": "Field", "given": "Thalia S", "initials": "TS"}, {"family": "Dizonno", "given": "Vanessa", "initials": "V"}, {"family": "Gattringer", "given": "Thomas", "initials": "T", "orcid": "0000-0002-6065-6576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08316e418e954e04b10df2f202714764.json"}}, {"family": "Jacobi", "given": "Christian", "initials": "C"}, {"family": "Devroye", "given": "Annemie", "initials": "A"}, {"family": "Lemmens", "given": "Robin", "initials": "R"}, {"family": "Kristoffersen", "given": "Espen Saxhaug", "initials": "ES", "orcid": "0000-0002-8999-5424", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73de5b72e1914dc7a18152e46ac4befc.json"}}, {"family": "Bandettini di Poggio", "given": "Monica", "initials": "M"}, {"family": "Ghiasian", "given": "Masoud", "initials": "M"}, {"family": "Karapanayiotides", "given": "Theodoros", "initials": "T"}, {"family": "Chatterton", "given": "Sophie", "initials": "S"}, {"family": "Wronski", "given": "Miriam", "initials": "M"}, {"family": "Ng", "given": "Karl", "initials": "K"}, {"family": "Kahnis", "given": "Robert", "initials": "R"}, {"family": "Geeraerts", "given": "Thomas", "initials": "T"}, {"family": "Reiner", "given": "Peggy", "initials": "P"}, {"family": "Cordonnier", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-5697-6892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba080d69348640eb90fba290f58fee11.json"}}, {"family": "Middeldorp", "given": "Saskia", "initials": "S"}, {"family": "Levi", "given": "Marcel", "initials": "M"}, {"family": "van Gorp", "given": "Eric C M", "initials": "ECM"}, {"family": "van de Beek", "given": "Diederik", "initials": "D"}, {"family": "Brodard", "given": "Justine", "initials": "J"}, {"family": "Kremer Hovinga", "given": "Johanna A", "initials": "JA"}, {"family": "Kruip", "given": "Marieke J H A", "initials": "MJHA"}, {"family": "Tatlisumak", "given": "Turgut", "initials": "T"}, {"family": "Ferro", "given": "Jos\u00e9 M", "initials": "JM"}, {"family": "Coutinho", "given": "Jonathan M", "initials": "JM"}, {"family": "Arnold", "given": "Marcel", "initials": "M"}, {"family": "Poli", "given": "Sven", "initials": "S"}, {"family": "Heldner", "given": "Mirjam R", "initials": "MR", "orcid": "0000-0002-3594-2159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8280f8c6ea3a486abae8acc6aa491985.json"}}], "type": "journal article", "published": "2022-06-10", "journal": {"title": "Ann Neurol", "issn": "1531-8249", "issn-l": null}, "abstract": "Cerebral venous thrombosis caused by vaccine-induced immune thrombotic thrombocytopenia (VITT-CVT) is a rare adverse effect of adenovirus-based SARS-CoV-2 vaccines. In March 2021, after autoimmune pathogenesis of VITT was discovered, treatment recommendations were developed. These comprised immunomodulation, non-heparin anticoagulants, and avoidance of platelet transfusion. The aim of this study was to evaluate adherence to these recommendations and its association with mortality.\n\nWe used data from an international prospective registry of patients with CVT after adenovirus-based SARS-CoV-2 vaccination. We analyzed possible, probable or definite VITT-CVT cases included until 18 January 2022. Immunomodulation entailed administration of intravenous immunoglobulins and/or plasmapheresis.\n\n99 VITT-CVT patients from 71 hospitals in 17 countries were analyzed. Five of 38 (13%), 11/24 (46%), and 28/37 (76%) of patients diagnosed in March, April, and from May onwards, respectively, were treated in-line with VITT recommendations (p<0.001). Overall, treatment according to recommendations had no statistically significant influence on mortality (14/44 (32%) vs 29/55 (52%), adjusted OR 0.43 (95%CI 0.16-1.19)). However, patients who received immunomodulation had lower mortality (19/65 (29%) vs 24/34 (70%), adjusted OR 0.19 (95%CI 0.06-0.58)). Treatment with non-heparin anticoagulants instead of heparins was not associated with lower mortality (17/51 (33%) vs 13/35 (37%), adjusted OR 0.70 (95%CI 0.24-2.04)). Mortality was also not significantly influenced by platelet transfusion (17/27 (63%) vs 26/72 (36%), adjusted OR 2.19 (95%CI 0.74-6.54)).\n\nIn VITT-CVT patients, adherence to VITT treatment recommendations improved over time. Immunomodulation seems crucial for reducing mortality of VITT-CVT. This article is protected by copyright. All rights reserved.", "doi": "10.1002/ana.26431", "pmid": "35689346", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-20T19:24:43.957Z", "modified": "2022-06-20T19:24:55.082Z"}, {"entity": "publication", "iuid": "213af95fecd449bb8691218aa8923c26", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/213af95fecd449bb8691218aa8923c26.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/213af95fecd449bb8691218aa8923c26"}}, "title": "Seven domains of persisting problems after hospital-treated Covid-19 indicate a need for a multiprofessional rehabilitation approach.", "authors": [{"family": "Hellgren", "given": "Lovisa", "initials": "L"}, {"family": "Levi", "given": "Richard", "initials": "R"}, {"family": "Divanoglou", "given": "Anestis", "initials": "A"}, {"family": "Birberg-Thornberg", "given": "Ulrika", "initials": "U"}, {"family": "Samuelsson", "given": "Kersti", "initials": "K"}], "type": "journal article", "published": "2022-06-09", "journal": {"title": "J Rehabil Med", "issn": "1651-2081", "issn-l": null}, "abstract": "Objectives To identify domains of persisting problems at 4 months after discharge in patients previously hospitalized due to COVID-19, with focus on the subgroup of patients reporting symptoms to an extent indicative of rehabilitation needs. Design Ambidirectional observational cohort study. Patients All patients with a laboratory-confirmed COVID-19 diagnosis admitted to hospital in a Swedish healthcare region during 1/03-31/05, 2020. After exclusion, 94% of all survivors (n=433) participated in the study. Forty-three percent (n=185) of these reported persisting problems indicating rehabilitation needs and formed a subgroup. Methods Explorative factor analysis based on results from comprehensive telephone interviews covering persisting symptoms, including assessment of impact in daily life. Results Seven domains were identified comprising problems related to vision, cognition, mental fatigue, swallowing, voice, sensorimotor dysfunction and feeling anxious/depressed. The patients in the subgroup reported a median of 8 symptoms/limitations affecting everyday life, and two thirds reported symptoms/limitations in three or more domains. Conclusions Seven problem domains corresponding to specific modalities of rehabilitative interventions were identified. As a majority of patients reported problems from several domains, multiprofessional teams in post-COVID-19 rehabilitation is implicated. Screening of patients previously hospitalized due to COVID-19 should cover all seven domains.", "doi": "10.2340/jrm.v54.2434", "pmid": "35678268", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-20T19:29:58.865Z", "modified": "2022-06-20T19:29:58.879Z"}, {"entity": "publication", "iuid": "9350efb6514a4278a52e306bfaf61a81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9350efb6514a4278a52e306bfaf61a81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9350efb6514a4278a52e306bfaf61a81"}}, "title": "Pre-pandemic Physical Function and Social Network in Relation to COVID-19-Associated Depressive Burden in Older Adults in Sweden.", "authors": [{"family": "Triolo", "given": "Federico", "initials": "F", "orcid": "0000-0002-8732-0036", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a5b676e886a4723942f5bbf96a4e4d8.json"}}, {"family": "Saadeh", "given": "Marguerita", "initials": "M", "orcid": "0000-0002-2689-5784", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/324dbc9ae7ec4e5daab17e7fab6a183c.json"}}, {"family": "Sj\u00f6berg", "given": "Linnea", "initials": "L"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Welmer", "given": "Anna-Karin", "initials": "AK", "orcid": "0000-0001-5819-8724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d248c60e17b48cfa3ea3e90abf1e710.json"}}, {"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A"}, {"family": "Dekhtyar", "given": "Serhiy", "initials": "S", "orcid": "0000-0002-3062-4848", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9767e9072f6a44f6853b4001340eee97.json"}}], "type": "journal article", "published": "2022-06-09", "journal": {"title": "Innov Aging", "issn": "2399-5300", "volume": "6", "issue": "5", "pages": "igac041", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic, as well as the measures intended to limit its spread, have likely affected older adults' depressive burden. Good physical functioning and a rich social network may benefit older adults' mental health. We examined whether pre-pandemic physical functioning and social network were associated with depressive burden during the first wave of the COVID-19 pandemic in Stockholm, Sweden.\n\nA telephone assessment of depressive burden using the symptoms of sadness, anxiety, worrying, reduced sleep, and reduced appetite was conducted in May-September 2020 in 930 older adults from the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K), an ongoing population-based study. Objective measures of gait speed, muscle strength, and balance; and self-reports of social connections and support were collected in 2016-2019. Logistic models were adjusted for sociodemographic, clinical, lifestyle, and pandemic-related factors (loneliness, change in physical and social engagement, and experience of death due to COVID-19).\n\nOnly good muscle strength (odds ratio [OR]: 0.53; 95% confidence interval [CI]: 0.32-0.85; ref: poor strength, \u226517 s) and rich social support (OR: 0.67; 95% CI: 0.45-0.99; ref: poor support) exhibited an independent association with depressive burden, even after accounting for pandemic-related factors. A combination of good muscle strength and rich social support were associated with the greatest reduction in depressive burden (OR: 0.35; 95% CI: 0.18-0.66; ref: poor social support and poor muscle strength).\n\nPrepandemic social support and muscle strength could supply older adults with resilience against the depressive burden associated with the COVID-19 pandemic.", "doi": "10.1093/geroni/igac041", "pmid": "35837440", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "igac041"}, {"db": "pmc", "key": "PMC9273957"}], "notes": [], "created": "2022-08-12T08:58:51.049Z", "modified": "2022-08-12T08:58:51.257Z"}, {"entity": "publication", "iuid": "d4ae1d7ec5f7481e9c9095dfeaf9e0e5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4ae1d7ec5f7481e9c9095dfeaf9e0e5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4ae1d7ec5f7481e9c9095dfeaf9e0e5"}}, "title": "In Vivo Visualization and Quantification of Neutrophil Elastase in Lungs of COVID-19 Patients - A First-In-Human Positron Emission Tomography Study with 11C-GW457427.", "authors": [{"family": "Antoni", "given": "Gunnar", "initials": "G"}, {"family": "Lubberink", "given": "Mark", "initials": "M"}, {"family": "S\u00f6rensen", "given": "Jens", "initials": "J"}, {"family": "Lindstr\u00f6m", "given": "Elin", "initials": "E"}, {"family": "Elgland", "given": "Mathias", "initials": "M"}, {"family": "Eriksson", "given": "Olof", "initials": "O"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Wanhainen", "given": "Anders", "initials": "A"}, {"family": "Sigfridsson", "given": "Jonathan", "initials": "J"}, {"family": "Skorup", "given": "Paul", "initials": "P"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}], "type": "journal article", "published": "2022-06-09", "journal": {"title": "J Nucl Med", "issn": "1535-5667", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "COVID-19 can cause life-threatening lung-inflammation that is suggested to be mediated by neutrophils, whose effector mechanisms in COVID-19 is inexplicit. The aim of the present work is to evaluate a novel PET tracer for neutrophil elastase in COVID-19 patients and healthy controls. METHODS: In this open-label, First-In-Man study, four patients with hypoxia due to COVID-19 and two healthy controls were investigated with positron emission tomography (PET) using the new selective and specific neutrophil elastase PET-tracer [11C]GW457427 and [15O]water for the visualization and quantification of NE and perfusion in the lungs, respectively. RESULTS: [11C]GW457427 accumulated selectively in lung areas with ground-glass opacities on computed tomography characteristic of COVID-19 suggesting high levels on NE in these areas. In the same areas perfusion was severely reduced in comparison to healthy lung tissue as measured with [15O]water. CONCLUSION: The data suggests that NE may be responsible for the severe lung inflammation in COVID-19 patients and that inhibition of NE could potentially reduce the acute inflammatory process and improve the condition.", "doi": "10.2967/jnumed.122.263974", "pmid": "35680418", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "jnumed.122.263974"}], "notes": [], "created": "2022-06-20T19:28:49.814Z", "modified": "2022-08-19T12:36:21.106Z"}, {"entity": "publication", "iuid": "5251c54c69ab46da86cb75a58d411edb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5251c54c69ab46da86cb75a58d411edb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5251c54c69ab46da86cb75a58d411edb"}}, "title": "Age and sex effects on DNA methylation sites linked to genes implicated in severe COVID-19 and SARS-CoV-2 host cell entry.", "authors": [{"family": "Bohlin", "given": "Jon", "initials": "J", "orcid": "0000-0002-0992-1311", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20544b4db3c44a34b7f11715729e927d.json"}}, {"family": "Page", "given": "Christian M", "initials": "CM", "orcid": "0000-0002-1897-3666", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82db13fac79542f6be91580db5e15f64.json"}}, {"family": "Lee", "given": "Yunsung", "initials": "Y"}, {"family": "Pettersson", "given": "John H-O", "initials": "JH", "orcid": "0000-0001-6665-7492", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59b007230a6741888ef96de5e210276c.json"}}, {"family": "Jugessur", "given": "Astanand", "initials": "A"}, {"family": "Magnus", "given": "Per", "initials": "P"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}], "type": "journal article", "published": "2022-06-09", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "6", "pages": "e0269105", "issn-l": "1932-6203"}, "abstract": "Male sex and advanced age are associated with severe symptoms of COVID-19. Sex and age also exhibit substantial associations with genome-wide DNA methylation (DNAm) differences in humans. Using a random sample of Illumina EPIC-based genome-wide methylomes from peripheral whole blood of 1,976 parents, participating in The Norwegian Mother, Father and Child Cohort Study (MoBa), we explored whether DNAm in genes linked to SARS-CoV-2 host cell entry and to severe COVID-19 were associated with sex and age. This was carried out by testing 1,572 DNAm sites (CpGs) located near 45 genes for associations with age and sex. We found that DNAm in 281 and 231 of 1,572 CpGs were associated (pFDR<0.01) with sex and aging, respectively. CpGs linked to SARS-CoV-2 host cell entry genes were all associated with age and sex, except for the ACE2 receptor gene (located on the X-chromosome), which was only associated with sex (pFDR<0.01). Furthermore, we examined whether 1,487 autosomal CpGs associated with host-cell entry and severe COVID-19 were more or less associated with sex and age than what would be expected from the same number of randomly sampled genome-wide CpGs. We found that the CpGs associated with host-cell entry and severe COVID-19 were not more or less associated with sex (R2 = 0.77, p = 0.09) than the CpGs sampled from random genomic regions; age was actually found to be significantly less so (R2 = 0.36, p = 0.04). Hence, while we found wide-spread associations between sex and age at CpGs linked to genes implicated with SARS-CoV-2 host cell entry and severe COVID-19, the effect from the sum of these CpGs was not stronger than that from randomly sampled CpGs; for age it was significantly less so. These findings could suggest that advanced age and male sex may not be unsurmountable barriers for the SARS-CoV-2 virus to evolve increased infectiousness.", "doi": "10.1371/journal.pone.0269105", "pmid": "35679253", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-27385"}], "notes": [], "created": "2022-06-20T19:29:30.046Z", "modified": "2022-06-20T19:29:30.205Z"}, {"entity": "publication", "iuid": "d1dde5aa6de64fe2b824de24260f6fd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1dde5aa6de64fe2b824de24260f6fd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1dde5aa6de64fe2b824de24260f6fd0"}}, "title": "Synthesizing Stakeholders Perspectives on Online Psychological Interventions to Improve the Mental Health of the Italian Population during the COVID-19 Pandemic: An Online Survey Study.", "authors": [{"family": "Bertuzzi", "given": "Vanessa", "initials": "V", "orcid": "0000-0002-8541-5357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7abc069e75034b0e96265c7d48fb95a2.json"}}, {"family": "Semonella", "given": "Michelle", "initials": "M"}, {"family": "Castelnuovo", "given": "Gianluca", "initials": "G", "orcid": "0000-0003-2633-9822", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7463db589ae343e5ae6a7bc47a917c22.json"}}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Pietrabissa", "given": "Giada", "initials": "G"}], "type": "journal article", "published": "2022-06-08", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "12", "issn-l": null}, "abstract": "The COVID-19 pandemic is expected to significantly increase the prevalence of mental health problems, thus raising the need for psychological support interventions around the world. Online psychological interventions have already been shown to be an effective solution to promote psychological treatments. Nevertheless, planning and developing an online intervention, involving possible stakeholders, might facilitate the dissemination of, willingness to use, and success of the future intervention. This study aims to explore and compare the experiences that Italians living in Italy and abroad had with available support services during the COVID-19 pandemic, their needs, and attitudes, as well as possible barriers to online psychological interventions. A sample of 1024 Italians (F = 69.8%; mean age = 41.3; SD = 15.3) was recruited through social media platforms and personal contacts and they were asked to complete an online survey. Results showed that perceived psychological distress during the COVID-19 pandemic improved. In Europe, psychological support was delivered mainly in person (69.0%), while online interventions were primarily used in extra-European countries (57%). Then, only 44% of the total sample was interested in trying an online psychological intervention. Various advantages and disadvantages were defined by stakeholders: The main advantages were the reduction in geographical distances, economic reasons, and the reduction in the waiting list; The main disadvantages were problems with technology, low motivation of users, and privacy/safety reasons. These data made it possible to improve the knowledge regarding the views and attitudes that Italians have about online psychological interventions, and shed light on how to increase the uptake of digital health.", "doi": "10.3390/ijerph19127008", "pmid": "35742257", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19127008"}, {"db": "pmc", "key": "PMC9222987"}], "notes": [], "created": "2022-08-19T05:46:23.067Z", "modified": "2022-08-19T05:47:08.175Z"}, {"entity": "publication", "iuid": "f2fc843354aa430c8c48e3c815fcfd04", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f2fc843354aa430c8c48e3c815fcfd04.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f2fc843354aa430c8c48e3c815fcfd04"}}, "title": "Perceptions of delay when afflicted by an acute myocardial infarction during the first wave of the COVID-19 pandemic.", "authors": [{"family": "Granstr\u00f6m", "given": "Johanna", "initials": "J", "orcid": "0000-0002-3895-3179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/577ea5c47de04511a9b34e470c4d8b67.json"}}, {"family": "Lantz", "given": "Pontus", "initials": "P", "orcid": "0000-0003-4037-3904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6754b9ed3cd45129f456eab5c1e27c2.json"}}, {"family": "Lidin", "given": "Matthias", "initials": "M", "orcid": "0000-0002-2297-5621", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/99c36a92228c473dbebfce62830d2f35.json"}}, {"family": "Wahlstr\u00f6m", "given": "Maria", "initials": "M", "orcid": "0000-0003-4339-9202", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d169b22b55c4b11aa7b13f718f5f97b.json"}}, {"family": "Nymark", "given": "Carolin", "initials": "C", "orcid": "0000-0003-0891-6358", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26ae7dfc5d824e6ba7fda3c21ac670ef.json"}}], "type": "journal article", "published": "2022-06-08", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "issn-l": null}, "abstract": "To describe the perceptions of delay in medical care-seeking, when afflicted by an acute myocardial infarction (AMI) during the first wave of the pandemic.\n\nA qualitative descriptive study with an inductive approach. Fourteen semi-structured interviews were conducted, analysed by qualitative content analysis with a manifest approach. One category and six sub-categories emerged. The decision was reached when the health threat was perceived as critical, which made the earlier thoughts of the pandemic fade away. The risk of infection during medical visits caused fear of contracting the disease. This resulted in hesitation, neglect of symptoms, and avoidance of healthcare visits. Following recommendations from authorities and media about personal responsibility was motivated by fear, affecting the care-seeking.\n\nIt appears that the COVID-19 pandemic raised the threshold for deciding to seek medical care when presenting with an AMI. The pandemic led to increased patient delay due to several reasons among which fear of contracting the disease was prominent. The emotion of fear was related to the external threat to one's own health, due to COVID-19, and not fear of symptoms related to an AMI. The media reporting the healthcare system as overloaded increased insecurity and may have had an influence on delay.", "doi": "10.1093/eurjcn/zvac021", "pmid": "35672906", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6603987"}], "notes": [], "created": "2022-06-20T19:31:19.093Z", "modified": "2022-06-20T19:31:31.810Z"}, {"entity": "publication", "iuid": "35522c10f3744041bf3b7022dcbaeb94", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/35522c10f3744041bf3b7022dcbaeb94.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/35522c10f3744041bf3b7022dcbaeb94"}}, "title": "Pandemetrics: systematically assessing, monitoring, and controlling the evolution of a pandemic.", "authors": [{"family": "Barone", "given": "Stefano", "initials": "S", "orcid": "0000-0002-0339-8435", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7da10883e83473e955b7894ad37b7e8.json"}}, {"family": "Chakhunashvili", "given": "Alexander", "initials": "A"}], "type": "journal article", "published": "2022-06-08", "journal": {"title": "Qual Quant", "issn": "0033-5177", "pages": "1-23", "issn-l": null}, "abstract": "The still ongoing pandemic of SARS-CoV-2 virus and COVID-19 disease, affecting the population worldwide, has demonstrated the need of more accurate methodologies for assessing, monitoring, and controlling an outbreak of such devastating proportions. Authoritative attempts have been made in traditional fields of medicine (epidemiology, virology, infectiology) to address these shortcomings, mainly by relying on mathematical and statistical modeling. However, here, we propose approaching the methodological work from a different, and to some extent alternative, standpoint. Applied systematically, the concepts and tools of statistical engineering and quality management, developed not only in healthcare settings, but also in other scientific contexts, can be very useful in assessing, monitoring, and controlling pandemic events. We propose a methodology based on a set of tools and techniques, formulas, graphs, and tables to support the decision-making concerning the management of a pandemic like COVID-19. This methodological body is hereby named Pandemetrics. This name intends to emphasize the peculiarity of our approach to measuring, and graphically presenting the unique context of the COVID-19 pandemic.", "doi": "10.1007/s11135-022-01424-7", "pmid": "35694109", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "1424"}, {"db": "pmc", "key": "PMC9174634"}], "notes": [], "created": "2022-06-20T18:19:25.551Z", "modified": "2022-06-20T18:19:25.628Z"}, {"entity": "publication", "iuid": "b1d98ccebcc9452f911869284786638e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1d98ccebcc9452f911869284786638e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1d98ccebcc9452f911869284786638e"}}, "title": "Incidence and severity of SARS-CoV-2 infection in former Q fever patients as compared to the Dutch population, 2020-2021.", "authors": [{"family": "den Boogert", "given": "Elisabeth Maria", "initials": "EM", "orcid": "0000-0003-4514-0026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb49158a9d6e43429ef9622f2712b614.json"}}, {"family": "de Lange", "given": "Marit M A", "initials": "MMA"}, {"family": "Wielders", "given": "Cornelia C H", "initials": "CCH", "orcid": "0000-0002-2413-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5b6b985406d4b43ac66c6336dd1e4fe.json"}}, {"family": "Rietveld", "given": "Ariene", "initials": "A"}, {"family": "RIVM COVID-19 Surveillance and Epidemiology Team", "given": "", "initials": ""}, {"family": "Knol", "given": "Mirjam J", "initials": "MJ"}, {"family": "van Gageldonk-Lafeber", "given": "Arianne B", "initials": "AB"}], "type": "journal article", "published": "2022-06-08", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": "150", "pages": "e116", "issn-l": null}, "abstract": "Surveillance data shows a geographical overlap between the early coronavirus disease 2019 (COVID-19) pandemic and the past Q fever epidemic (2007-2010) in the Netherlands. We investigated the relationship between past Q fever and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in 2020/2021, using a retrospective matched cohort study.In January 2021, former Q fever patients received a questionnaire on demographics, SARS-CoV-2 test results and related hospital/intensive care unit (ICU) admissions. SARS-CoV-2 incidence with 95% confidence intervals (CI) in former Q fever patients and standardised incidence ratios (SIR) to compare to the age-standardised SARS-CoV-2 incidence in the general regional population were calculated.Among 890 former Q fever patients (response rate: 68%), 66 had a PCR-confirmed SARS-CoV-2 infection. Of these, nine (14%) were hospitalised and two (3%) were admitted to ICU. From February to June 2020 the SARS-CoV-2 incidence was 1573/100 000 (95% CI 749-2397) in former Q fever patients and 695/100 000 in the general population (SIR 2.26; 95% CI 1.24-3.80). The incidence was not significantly higher from September 2020 to February 2021.We found no sufficient evidence for a difference in SARS-CoV-2 incidence or an increased severity in former Q fever patients vs. the general population during the period with widespread SARS-CoV-2 testing availability (September 2020-February 2021). This indicates that former Q fever patients do not have a higher risk of SARS-CoV-2 infection.", "doi": "10.1017/S0950268822001029", "pmid": "35730315", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0950268822001029"}, {"db": "pmc", "key": "PMC9237486"}], "notes": [], "created": "2022-08-17T13:06:21.531Z", "modified": "2022-08-17T13:06:21.622Z"}, {"entity": "publication", "iuid": "c7207f8b8ccf44f4a2dd7d2a19c2e6b8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7207f8b8ccf44f4a2dd7d2a19c2e6b8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7207f8b8ccf44f4a2dd7d2a19c2e6b8"}}, "title": "COVID-19 news and the US equity market interactions: An inspection through econometric and machine learning lens.", "authors": [{"family": "Jana", "given": "Rabin K", "initials": "RK"}, {"family": "Ghosh", "given": "Indranil", "initials": "I"}, {"family": "Jawadi", "given": "Fredj", "initials": "F", "orcid": "0000-0003-3655-8391", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a38cc17b4a74cc895fcdb29dcd4a8b3.json"}}, {"family": "Uddin", "given": "Gazi Salah", "initials": "GS"}, {"family": "Sousa", "given": "Ricardo M", "initials": "RM"}], "type": "news", "published": "2022-06-08", "journal": {"title": "Ann Oper Res", "issn": "0254-5330", "issn-l": null, "volume": null, "issue": null, "pages": "1-22"}, "abstract": "This study investigates the impact of COVID-19 on the US equity market during the first wave of Coronavirus using a wide range of econometric and machine learning approaches. To this end, we use both daily data related to the US equity market sectors and data about the COVID-19 news over January 1, 2020-March 20, 2020. Accordingly, we show that at an early stage of the outbreak, global COVID-19s fears have impacted the US equity market even differently across sectors. Further, we also find that, as the pandemic gradually intensified its footprint in the US, local fears manifested by daily infections emerged more powerfully compared to its global counterpart in impairing the short-term dynamics of US equity markets.", "doi": "10.1007/s10479-022-04744-x", "pmid": "35698596", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "4744"}, {"db": "pmc", "key": "PMC9175525"}], "notes": [], "created": "2022-06-20T18:17:51.292Z", "modified": "2022-11-09T08:41:00.145Z"}, {"entity": "publication", "iuid": "6b3870582e3b46aca03e66295d52f284", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b3870582e3b46aca03e66295d52f284.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b3870582e3b46aca03e66295d52f284"}}, "title": "Understanding the Role and Impact of Poly (Ethylene Glycol) (PEG) on Nanoparticle Formulation: Implications for COVID-19 Vaccines.", "authors": [{"family": "Pad\u00edn-Gonz\u00e1lez", "given": "Esperanza", "initials": "E"}, {"family": "Lancaster", "given": "Pearl", "initials": "P"}, {"family": "Bottini", "given": "Massimo", "initials": "M"}, {"family": "Gasco", "given": "Paolo", "initials": "P"}, {"family": "Tran", "given": "Lang", "initials": "L"}, {"family": "Fadeel", "given": "Bengt", "initials": "B"}, {"family": "Wilkins", "given": "Terence", "initials": "T"}, {"family": "Monopoli", "given": "Marco P", "initials": "MP"}], "type": "journal article", "published": "2022-06-07", "journal": {"title": "Front Bioeng Biotechnol", "issn": "2296-4185", "volume": "10", "pages": "882363", "issn-l": null}, "abstract": "Poly (ethylene glycol) (PEG) is a widely used polymer in a variety of consumer products and in medicine. PEGylation refers to the conjugation of PEG to drugs or nanoparticles to increase circulation time and reduce unwanted host responses. PEG is viewed as being well-tolerated, but previous studies have identified anti-PEG antibodies and so-called pseudoallergic reactions in certain individuals. The increased use of nanoparticles as contrast agents or in drug delivery, along with the introduction of mRNA vaccines encapsulated in PEGylated lipid nanoparticles has brought this issue to the fore. Thus, while these vaccines have proven to be remarkably effective, rare cases of anaphylaxis have been reported, and this has been tentatively ascribed to the PEGylated carriers, which may trigger complement activation in susceptible individuals. Here, we provide a general overview of the use of PEGylated nanoparticles for pharmaceutical applications, and we discuss the activation of the complement cascade that might be caused by PEGylated nanomedicines for a better understanding of these immunological adverse reactions.", "doi": "10.3389/fbioe.2022.882363", "pmid": "35747492", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "882363"}, {"db": "pmc", "key": "PMC9209764"}], "notes": [], "created": "2022-08-19T05:41:06.956Z", "modified": "2022-08-19T05:41:06.990Z"}, {"entity": "publication", "iuid": "f0eee78f85084e239331766ec731525b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f0eee78f85084e239331766ec731525b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f0eee78f85084e239331766ec731525b"}}, "title": "Renin-Angiotensin Aldosterone System Inhibitors and COVID-19: A Systematic Review and Meta-Analysis Revealing Critical Bias Across a Body of Observational Research.", "authors": [{"family": "Loader", "given": "Jordan", "initials": "J", "orcid": "0000-0001-5623-7478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb84661f9eee4ff6aa5580311b1bf572.json"}}, {"family": "Taylor", "given": "Frances C", "initials": "FC"}, {"family": "Lampa", "given": "Erik", "initials": "E"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2c4588f000c470abf08f2e40852b6d1.json"}}], "type": "journal article", "published": "2022-06-07", "journal": {"title": "J Am Heart Assoc", "issn": "2047-9980", "volume": "11", "issue": "11", "pages": "e025289", "issn-l": null}, "abstract": "Background Renin-angiotensin aldosterone system (RAAS) inhibitor-COVID-19 studies, observational in design, appear to use biased methods that can distort the interaction between RAAS inhibitor use and COVID-19 risk. This study assessed the extent of bias in that research and reevaluated RAAS inhibitor-COVID-19 associations in studies without critical risk of bias. Methods and Results Searches were performed in MEDLINE, EMBASE, and CINAHL databases (December 1, 2019 to October 21, 2021) identifying studies that compared the risk of infection and/or severe COVID-19 outcomes between those using or not using RAAS inhibitors (ie, angiotensin-converting enzyme inhibitors or angiotensin II type-I receptor blockers). Weighted hazard ratios (HR) and 95% CIs were extracted and pooled in fixed-effects meta-analyses, only from studies without critical risk of bias that assessed severe COVID-19 outcomes. Of 169 relevant studies, 164 had critical risks of bias and were excluded. Ultimately, only two studies presented data relevant to the meta-analysis. In 1 351 633 people with uncomplicated hypertension using a RAAS inhibitor, calcium channel blocker, or thiazide diuretic in monotherapy, the risk of hospitalization (angiotensin-converting enzyme inhibitor: HR, 0.76; 95% CI, 0.66-0.87; P<0.001; angiotensin II type-I receptor blockers: HR, 0.86; 95% CI, 0.77-0.97; P=0.015) and intubation or death (angiotensin-converting enzyme inhibitor: HR, 0.64; 95% CI, 0.48-0.85; P=0.002; angiotensin II type-I receptor blockers: HR, 0.74; 95% CI, 0.58-0.95; P=0.019) with COVID-19 was lower in those using a RAAS inhibitor. However, these protective effects are probably not clinically relevant. Conclusions This study reveals the critical risk of bias that exists across almost an entire body of COVID-19 research, raising an important question: Were research methods and/or peer-review processes temporarily weakened during the surge of COVID-19 research or is this lack of rigor a systemic problem that also exists outside pandemic-based research? Registration URL: www.crd.york.ac.uk/prospero/; Unique identifier: CRD42021237859.", "doi": "10.1161/JAHA.122.025289", "pmid": "35624081", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T17:43:48.128Z", "modified": "2022-06-21T17:44:16.895Z"}, {"entity": "publication", "iuid": "63b3d52cc7054ddc857aefb8e82a27ec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63b3d52cc7054ddc857aefb8e82a27ec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63b3d52cc7054ddc857aefb8e82a27ec"}}, "title": "COVID-19 pandemic is associated with increased sleep disturbances and mental health symptoms but not help-seeking: a cross-sectional nation-wide study.", "authors": [{"family": "Moreno", "given": "Claudia Roberta de Castro", "initials": "CRC", "orcid": "0000-0003-1839-9673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a22ff4be344d4bb7941b0b74d4636afe.json"}}, {"family": "Conway", "given": "Silvia G", "initials": "SG"}, {"family": "Assis", "given": "M\u00e1rcia", "initials": "M"}, {"family": "Genta", "given": "Pedro Rodrigues", "initials": "PR"}, {"family": "Pachito", "given": "Daniela V", "initials": "DV"}, {"family": "Tavares", "given": "Almir", "initials": "A"}, {"family": "Sguillar", "given": "Danilo A", "initials": "DA"}, {"family": "Moreira", "given": "Gustavo", "initials": "G"}, {"family": "Drager", "given": "Luciano F", "initials": "LF"}, {"family": "Bacelar", "given": "Andrea", "initials": "A"}], "type": "journal article", "published": "2022-06-07", "journal": {"title": "Sleep Sci", "issn": "1984-0659", "volume": "15", "issue": "1", "pages": "1-7", "issn-l": null}, "abstract": "This study aimed firstly to describe sleep-related and mental health symptoms before and during the COVID-19 pandemic in a national-wide sample and, secondly, to verify attitudes towards help-seeking to treat these symptoms.\n\nData were collected through an online questionnaire sent through the Brazilian Sleep Association's social media. The questionnaire included sociodemographic and sleep aspects questions currently and before the pandemic period. In addition, the survey addressed current and previous anxiety, depression, and burnout symptoms. The outcome help-seeking was addressed in the questionnaire as well by a single question asked when the participant reported mental or sleep problems.\n\nThe study covered 6,360 participants, mean age 43.5 years (SD=14.3), 76.7% female and 63.7% with undergraduate or higher degree filled out the survey. Seventy percent of participants reported sleep disturbances and 80% reported symptoms of anxiety during the pandemic. Help-seeking behavior was found only in one third of them. Hours of sleep reduced from 7.12 to 6.2h, which can be related with the increase in 28.2% of dissatisfaction with sleep duration during the pandemic. The highest frequency of complaints related to sleep was difficulty to fall asleep three or more times a week (going from 27.6% before the pandemic to 58.9% during the pandemic; p<0.001). Moreover, it was observed that help-seeking was more prevalent in men than women, and more in younger participants than in older ones.\n\nThere was an increase of sleep and mental self-reported problems during the pandemic, which was not followed by help-seeking.", "doi": "10.5935/1984-0063.20220027", "pmid": "35662970", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9153976"}], "notes": [], "created": "2022-06-20T19:35:14.867Z", "modified": "2022-06-20T19:35:14.966Z"}, {"entity": "publication", "iuid": "a4bae0fecd924d40a9766319b6c23c26", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a4bae0fecd924d40a9766319b6c23c26.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a4bae0fecd924d40a9766319b6c23c26"}}, "title": "Associations between integrase strand-transfer inhibitors and cardiovascular disease in people living with HIV: a multicentre prospective study from the RESPOND cohort consortium.", "authors": [{"family": "Neesgaard", "given": "Bastian", "initials": "B"}, {"family": "Greenberg", "given": "Lauren", "initials": "L"}, {"family": "Mir\u00f3", "given": "Jose M", "initials": "JM"}, {"family": "Grabmeier-Pfistershammer", "given": "Katharina", "initials": "K"}, {"family": "Wandeler", "given": "Gilles", "initials": "G"}, {"family": "Smith", "given": "Colette", "initials": "C"}, {"family": "De Wit", "given": "St\u00e9phane", "initials": "S"}, {"family": "Wit", "given": "Ferdinand", "initials": "F"}, {"family": "Pelchen-Matthews", "given": "Annegret", "initials": "A"}, {"family": "Mussini", "given": "Cristina", "initials": "C"}, {"family": "Castagna", "given": "Antonella", "initials": "A"}, {"family": "Pradier", "given": "Christian", "initials": "C"}, {"family": "d'Arminio Monforte", "given": "Antonella", "initials": "A"}, {"family": "Vehreschild", "given": "J\u00f6rg J", "initials": "JJ"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Anne", "given": "Alain V", "initials": "AV"}, {"family": "Carr", "given": "Andrew", "initials": "A"}, {"family": "Bansi-Matharu", "given": "Loveleen", "initials": "L"}, {"family": "Lundgren", "given": "Jens D", "initials": "JD"}, {"family": "Garges", "given": "Harmony", "initials": "H"}, {"family": "Rogatto", "given": "Felipe", "initials": "F"}, {"family": "Zangerle", "given": "Robert", "initials": "R"}, {"family": "G\u00fcnthard", "given": "Huldrych F", "initials": "HF"}, {"family": "Rasmussen", "given": "Line D", "initials": "LD"}, {"family": "Necsoi", "given": "Coca", "initials": "C"}, {"family": "van der Valk", "given": "Marc", "initials": "M"}, {"family": "Menozzi", "given": "Marianna", "initials": "M"}, {"family": "Muccini", "given": "Camilla", "initials": "C"}, {"family": "Peters", "given": "Lars", "initials": "L"}, {"family": "Mocroft", "given": "Amanda", "initials": "A"}, {"family": "Ryom", "given": "Lene", "initials": "L"}], "type": "journal article", "published": "2022-06-07", "journal": {"title": "Lancet HIV", "issn": "2352-3018", "issn-l": null}, "abstract": "Although associations between older antiretroviral drug classes and cardiovascular disease in people living with HIV are well described, there is a paucity of data regarding a possible association with integrase strand-transfer inhibitors (INSTIs). We investigated whether exposure to INSTIs was associated with an increased incidence of cardiovascular disease.\n\nRESPOND is a prospective, multicentre, collaboration study between 17 pre-existing European and Australian cohorts and includes more than 32 000 adults living with HIV in clinical care after Jan 1, 2012. Individuals were eligible for inclusion in these analyses if they were older than 18 years, had CD4 cell counts and HIV viral load measurements in the 12 months before or within 3 months after baseline (latest of cohort enrolment or Jan 1, 2012), and had no exposure to INSTIs before baseline. These individuals were subsequently followed up to the earliest of the first cardiovascular disease event (ie, myocardial infarction, stroke, or invasive cardiovascular procedure), last follow-up, or Dec 31, 2019. We used multivariable negative binomial regression to assess associations between cardiovascular disease and INSTI exposure (0 months [no exposure] vs >0 to 6 months, >6 to 12 months, >12 to 24 months, >24 to 36 months, and >36 months), adjusted for cardiovascular risk factors. RESPOND is registered with ClinicalTrials.gov, NCT04090151, and is ongoing.\n\n29 340 people living with HIV were included in these analyses, of whom 7478 (25\u00b75%) were female, 21 818 (74\u00b74%) were male, and 44 (<1%) were transgender, with a median age of 44\u00b73 years (IQR 36\u00b72-51\u00b73) at baseline. As of Dec 31, 2019, 14 000 (47\u00b77%) of 29 340 participants had been exposed to an INSTI. During a median follow-up of 6\u00b716 years (IQR 3\u00b787-7\u00b752; 160 252 person-years), 748 (2\u00b75%) individuals had a cardiovascular disease event (incidence rate of 4\u00b767 events [95% CI 4\u00b734-5\u00b701] per 1000 person-years of follow-up). The crude cardiovascular disease incidence rate was 4\u00b719 events (3\u00b783-4\u00b757) per 1000 person-years in those with no INSTI exposure, which increased to 8\u00b746 events (6\u00b758-10\u00b771) per 1000 person-years in those with more than 0 months to 6 months of exposure, and gradually decreased with increasing length of exposure, until it decreased to similar levels of no exposure at more than 24 months of exposure (4\u00b725 events [2\u00b789-6\u00b704] per 1000 person-years among those with >24 to 36 months of exposure). Compared with those with no INSTI exposure, the risk of cardiovascular disease was increased in the first 24 months of INSTI exposure and thereafter decreased to levels similar to those never exposed (>0 to 6 months of exposure: adjusted incidence rate ratio of 1\u00b785 [1\u00b744-2\u00b739]; >6 to 12 months of exposure: 1\u00b719 [0\u00b784-1\u00b768]; >12 to 24 months of exposure: 1\u00b746 [1\u00b713-1\u00b788]; >24 to 36 months of exposure: 0\u00b789 [0\u00b762-1\u00b729]; and >36 months of exposure: 0\u00b796 [0\u00b769-1\u00b733]; p<0\u00b70001).\n\nAlthough the potential for unmeasured confounding and channelling bias cannot fully be excluded, INSTIs initiation was associated with an early onset, excess incidence of cardiovascular disease in the first 2 years of exposure, after accounting for known cardiovascular disease risk factors. These early findings call for analyses in other large studies, and the potential underlying mechanisms explored further.\n\nThe CHU St Pierre Brussels HIV Cohort, The Austrian HIV Cohort Study, The Australian HIV Observational Database, The AIDS Therapy Evaluation in the Netherlands National Observational HIV cohort, The EuroSIDA cohort, The Frankfurt HIV Cohort Study, The Georgian National AIDS Health Information System, The Nice HIV Cohort, The ICONA Foundation, The Modena HIV Cohort, The PISCIS Cohort Study, The Swiss HIV Cohort Study, The Swedish InfCare HIV Cohort, The Royal Free HIV Cohort Study, The San Raffaele Scientific Institute, The University Hospital Bonn HIV Cohort and The University of Cologne HIV Cohorts, ViiV Healthcare, and Gilead Sciences.", "doi": "10.1016/S2352-3018(22)00094-7", "pmid": "35688166", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2352-3018(22)00094-7"}, {"db": "ClinicalTrials.gov", "key": "NCT04090151"}], "notes": [], "created": "2022-06-20T19:25:55.874Z", "modified": "2022-06-20T19:25:55.914Z"}, {"entity": "publication", "iuid": "b7d2e056b4524e9ba6c651f6f889d7fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b7d2e056b4524e9ba6c651f6f889d7fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b7d2e056b4524e9ba6c651f6f889d7fc"}}, "title": "Adaptive governance of urban green spaces across Latin America ---Insights amid COVID-19.", "authors": [{"family": "Sainz-Santamaria", "given": "Jaime", "initials": "J"}, {"family": "Martinez-Cruz", "given": "Adan L", "initials": "AL"}], "type": "journal article", "published": "2022-06-07", "journal": {"title": "Urban For Urban Green", "issn": "1618-8667", "issn-l": null, "volume": null, "issue": null, "pages": "127629"}, "abstract": "Urban green spaces' well documented role as a hub for physical and mental health was enhanced by restrictions to mobility issued worldwide as a response to COVID-19. In this context, managers of urban green spaces (UGS) were prompted to provide controlled access under impromptu safety protocols. This unprecedented challenge required planning and operational strengths reflecting flexibility, innovation and learning. These management features are essential for an adaptive governance -an underdeveloped research topic within the study of UGS. Using eighteen semi-structured interviews from six countries, we analyze adaptive governance as reflected by UGS managers' responses across Latin America -a region where access to UGS is a matter of public health and of environmental justice. We document responses that can be categorized based on the governance arrangement in place. On one hand, both polycentric and dedicated-management governances have been able to learn through piloting ideas, adapting personnel roles and the function of UGS infrastructure, and adjusting their decision-making process. On the other hand, managers within municipal public services areas -the most prevalent governance arrangement across Latin America- report difficulty to adapt -likely due to their dependence on political will, lack of continuity due limited autonomy, insufficient budgets, absence of formal paths to self-funding, shortage of technical know-how, and insufficient citizens' involvement. We discuss implications of UGS adaptive governance in terms of capacity to deal with future public health, climate-related or other types of shocks.", "doi": "10.1016/j.ufug.2022.127629", "pmid": "35692898", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S1618-8667(22)00172-8"}, {"db": "pmc", "key": "PMC9173828"}], "notes": [], "created": "2022-06-20T18:19:42.797Z", "modified": "2022-11-09T08:41:42.833Z"}, {"entity": "publication", "iuid": "a01b9a875b2a471eb4148059febe5472", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a01b9a875b2a471eb4148059febe5472.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a01b9a875b2a471eb4148059febe5472"}}, "title": "I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations.", "authors": [{"family": "Files", "given": "Daniel Clark", "initials": "DC", "orcid": "0000-0002-1595-4080", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7921bbd010a24850ba0c57d0e591d5ba.json"}}, {"family": "Matthay", "given": "Michael A", "initials": "MA"}, {"family": "Calfee", "given": "Carolyn S", "initials": "CS"}, {"family": "Aggarwal", "given": "Neil R", "initials": "NR"}, {"family": "Asare", "given": "Adam L", "initials": "AL"}, {"family": "Beitler", "given": "Jeremy R", "initials": "JR"}, {"family": "Berger", "given": "Paul A", "initials": "PA"}, {"family": "Burnham", "given": "Ellen L", "initials": "EL"}, {"family": "Cimino", "given": "George", "initials": "G"}, {"family": "Coleman", "given": "Melissa H", "initials": "MH"}, {"family": "Crippa", "given": "Alessio", "initials": "A"}, {"family": "Discacciati", "given": "Andrea", "initials": "A"}, {"family": "Gandotra", "given": "Sheetal", "initials": "S", "orcid": "0000-0002-5475-9704", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/875d45a15b964498992ab468206dd2fa.json"}}, {"family": "Gibbs", "given": "Kevin W", "initials": "KW"}, {"family": "Henderson", "given": "Paul T", "initials": "PT"}, {"family": "Ittner", "given": "Caroline A G", "initials": "CAG"}, {"family": "Jauregui", "given": "Alejandra", "initials": "A"}, {"family": "Khan", "given": "Kashif T", "initials": "KT"}, {"family": "Koff", "given": "Jonathan L", "initials": "JL"}, {"family": "Lang", "given": "Julie", "initials": "J"}, {"family": "LaRose", "given": "Mary", "initials": "M"}, {"family": "Levitt", "given": "Joe", "initials": "J"}, {"family": "Lu", "given": "Ruixiao", "initials": "R"}, {"family": "McKeehan", "given": "Jeffrey D", "initials": "JD"}, {"family": "Meyer", "given": "Nuala J", "initials": "NJ"}, {"family": "Russell", "given": "Derek W", "initials": "DW", "orcid": "0000-0002-2716-1344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13774f6125b448b1a63423f9f5fa1cab.json"}}, {"family": "Thomas", "given": "Karl W", "initials": "KW"}, {"family": "Eklund", "given": "Martin", "initials": "M"}, {"family": "Esserman", "given": "Laura J", "initials": "LJ"}, {"family": "Liu", "given": "Kathleen D", "initials": "KD"}, {"family": "ISPY COVID Adaptive Platform Trial Network", "given": "", "initials": ""}, {"family": "undefined", "given": "", "initials": ""}], "type": "journal article", "published": "2022-06-06", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "6", "pages": "e060664", "issn-l": "2044-6055"}, "abstract": "The COVID-19 pandemic brought an urgent need to discover novel effective therapeutics for patients hospitalised with severe COVID-19. The Investigation of Serial studies to Predict Your Therapeutic Response with Imaging And moLecular Analysis (ISPY COVID-19 trial) was designed and implemented in early 2020 to evaluate investigational agents rapidly and simultaneously on a phase 2 adaptive platform. This manuscript outlines the design, rationale, implementation and challenges of the ISPY COVID-19 trial during the first phase of trial activity from April 2020 until December 2021.\n\nThe ISPY COVID-19 Trial is a multicentre open-label phase 2 platform trial in the USA designed to evaluate therapeutics that may have a large effect on improving outcomes from severe COVID-19. The ISPY COVID-19 Trial network includes academic and community hospitals with significant geographical diversity across the country. Enrolled patients are randomised to receive one of up to four investigational agents or a control and are evaluated for a family of two primary outcomes-time to recovery and mortality. The statistical design uses a Bayesian model with 'stopping' and 'graduation' criteria designed to efficiently discard ineffective therapies and graduate promising agents for definitive efficacy trials. Each investigational agent arm enrols to a maximum of 125 patients per arm and is compared with concurrent controls. As of December 2021, 11 investigational agent arms had been activated, and 8 arms were complete. Enrolment and adaptation of the trial design are ongoing.\n\nISPY COVID-19 operates under a central institutional review board via Wake Forest School of Medicine IRB00066805. Data generated from this trial will be reported in peer-reviewed medical journals.\n\nNCT04488081.", "doi": "10.1136/bmjopen-2021-060664", "pmid": "35667714", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-060664"}, {"db": "ClinicalTrials.gov", "key": "NCT04488081"}], "notes": [], "created": "2022-06-20T19:34:00.059Z", "modified": "2022-06-20T19:34:14.060Z"}, {"entity": "publication", "iuid": "cac43704a1494c379d09ea40681613e4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cac43704a1494c379d09ea40681613e4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cac43704a1494c379d09ea40681613e4"}}, "title": "Critical care nurses' perception of moral distress in intensive care during the COVID-19 pandemic - A pilot study.", "authors": [{"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Nordin", "given": "Anna", "initials": "A"}, {"family": "Engstr\u00f6m", "given": "\u00c5sa", "initials": "\u00c5"}], "type": "journal article", "published": "2022-06-06", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "pages": "103279", "issn-l": null}, "abstract": "To describe critical care nurses' perception of moral distress during the second year of the COVID-19 pandemic.\n\nA cross-sectional study involving a questionnaire was conducted. Participants responded to the Italian version of the Moral Distress Scale-Revised, which consists of 14 items divided in dimensions Futile care (three items), Ethical misconduct (five items), Deceptive communication (three items) and Poor teamwork (three items). For each item, participants were also invited to write about their experiences and participants' intention to leave a position now was measured by a dichotomous question. The data were analysed with descriptive statistics and qualitative content analysis. The study followed the checklist (CHERRIES) for reporting results of internet surveys.\n\nCritical care nurses (n = 71) working in Swedish adult intensive care units.\n\nCritical care nurses experienced the intensity of moral distress as the highest when no one decided to withdraw ventilator support to a hopelessly ill person (Futile care), and when they had to assist another physician or nurse who provided incompetent care (Poor teamwork). Thirty-nine percent of critical care nurses were considering leaving their current position because of moral distress.\n\nDuring the COVID-19 pandemic, critical care nurses, due to their education and experience of intensive care nursing, assume tremendous responsibility for critically ill patients. Throughout, communication within the intensive care team seems to have a bearing on the degree of moral distress. Improvements in communication and teamwork are needed to reduce moral distress among critical care nurses.", "doi": "10.1016/j.iccn.2022.103279", "pmid": "35688753", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(22)00082-9"}], "notes": [], "created": "2022-06-20T19:25:13.462Z", "modified": "2022-06-20T19:25:25.362Z"}, {"entity": "publication", "iuid": "6ebf9ae4745f4cbf92e3d685d0c1e517", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ebf9ae4745f4cbf92e3d685d0c1e517.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ebf9ae4745f4cbf92e3d685d0c1e517"}}, "title": "Angiopoietin-2 Inhibition of Thrombomodulin-Mediated Anticoagulation-A Novel Mechanism That May Contribute to Hypercoagulation in Critically Ill COVID-19 Patients.", "authors": [{"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Fromell", "given": "Karin", "initials": "K", "orcid": "0000-0001-8905-8791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9342eb4305954aba853bdf3a8153ab67.json"}}, {"family": "Larsson", "given": "Anders", "initials": "A", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2be858ab604743b72383dfdcd14689.json"}}, {"family": "Persson", "given": "Barbro", "initials": "B"}, {"family": "Nilsson", "given": "Bo", "initials": "B"}, {"family": "Quaggin", "given": "Susan E", "initials": "SE"}, {"family": "Betsholtz", "given": "Christer", "initials": "C"}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Jeansson", "given": "Marie", "initials": "M", "orcid": "0000-0003-1075-8563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae2c63715b0f4a5b8127552ab84a1bf3.json"}}], "type": "journal article", "published": "2022-06-06", "journal": {"title": "Biomedicines", "issn": "2227-9059", "issn-l": null, "volume": "10", "issue": "6", "pages": null}, "abstract": "Hypercoagulation and endothelial dysfunction play central roles in severe forms of COVID-19 infections, but the molecular mechanisms involved are unclear. Increased plasma levels of the inflammatory cytokine and TIE2 receptor antagonist Angiopoietin-2 were reported in severely ill COVID-19 patients. In vitro experiments suggest that Angiopoietin-2 bind and inhibits thrombomodulin. Thrombomodulin is expressed on the luminal surface of endothelial cells where it is an important member of the intrinsic anticoagulant pathway through activation of protein C. Using clinical data, mouse models, and in vitro assays, we tested if Angiopoietin-2 plays a causal role in COVID-19-associated hypercoagulation through direct inhibition of thrombin/thrombomodulin-mediated physiological anticoagulation. Angiopoietin-2 was measured in 61 patients at admission, and after 10 days in the 40 patients remaining in the ICU. We found that Angiopoietin-2 levels were increased in COVID-19 patients in correlation with disease severity, hypercoagulation, and mortality. In support of a direct effect of Angiopoietin-2 on coagulation, we found that injected Angiopoietin-2 in mice associated to thrombomodulin and resulted in a shortened tail bleeding time, decreased circulating levels of activated protein C, and increased plasma thrombin/antithrombin complexes. Conversely, bleeding time was increased in endothelial-specific Angiopoietin-2 knockout mice, while knockout of Tie2 had no effect on tail bleeding. Using in vitro assays, we found that Angiopoietin-2 inhibited thrombomodulin-mediated anticoagulation and protein C activation in human donor plasma. Our data suggest a novel in vivo mechanism for Angiopoietin-2 in COVID-19-associated hypercoagulation, implicating that Angiopoietin-2 inhibitors may be effective in the treatment of hypercoagulation in severe COVID-19 infection.", "doi": "10.3390/biomedicines10061333", "pmid": "35740360", "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "biomedicines10061333"}, {"db": "pmc", "key": "PMC9220312"}, {"db": "URL", "key": "https://doi.org/10.17044/scilifelab.14229410", "description": "https://doi.org/10.17044/scilifelab.14229410"}], "notes": [], "created": "2022-08-19T05:49:08.807Z", "modified": "2022-08-19T12:36:44.560Z"}, {"entity": "publication", "iuid": "8a0ac9252cfb436fbe1fe3f923db30de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a0ac9252cfb436fbe1fe3f923db30de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a0ac9252cfb436fbe1fe3f923db30de"}}, "title": "Hospital bed occupancy for COVID-19 or with SARS-CoV-2 infection in a Swedish county during the omicron wave.", "authors": [{"family": "Spreco", "given": "Armin", "initials": "A"}, {"family": "Andersson", "given": "Christer", "initials": "C"}, {"family": "Sj\u00f6dahl", "given": "Rune", "initials": "R"}, {"family": "Dahlstr\u00f6m", "given": "\u00d6rjan", "initials": "\u00d6"}, {"family": "Timpka", "given": "Toomas", "initials": "T", "orcid": "0000-0001-6049-5402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebcb4fac20f845a4bd9eaa4bf1660ebb.json"}}], "type": "letter", "published": "2022-06-05", "journal": {"title": "Influenza Other Respir Viruses", "issn": "1750-2659", "issn-l": null}, "abstract": null, "doi": "10.1111/irv.13019", "pmid": "35666005", "labels": {"Category: Omicron VoC": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-20T19:34:35.273Z", "modified": "2022-06-20T19:34:35.310Z"}, {"entity": "publication", "iuid": "97e8169c1e9d46fc836abc9d4315fbd7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/97e8169c1e9d46fc836abc9d4315fbd7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/97e8169c1e9d46fc836abc9d4315fbd7"}}, "title": "Organizational logics in time of crises: How physicians narrate the healthcare response to the Covid-19 pandemic in Swedish hospitals.", "authors": [{"family": "Jacobsson", "given": "Maritha", "initials": "M"}, {"family": "H\u00e4rgestam", "given": "Maria", "initials": "M"}, {"family": "B\u00e5\u00e5the", "given": "Fredrik", "initials": "F"}, {"family": "Hagqvist", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2022-06-03", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "volume": "22", "issue": "1", "pages": "738", "issn-l": null}, "abstract": "The COVID-19 pandemic has challenged healthcare organizations and puts focus on risk management in many ways. Both medical staff and leaders at various levels have been forced to find solutions to problems they had not previously encountered. This study aimed to explore how physicians in Sweden narrated the changes in organizational logic in response to the Covid-19 pandemic using neo-institutional theory and discursive psychology. In specific, we aimed to explore how physicians articulated their understanding of if and, in that case, how the organizational logic has changed during this crisis response.\n\nThe empirical material stems from interviews with 29 physicians in Sweden in the summer and autumn of 2020. They were asked to reflect on the organizational response to the pandemic focusing on leadership, support, working conditions, and patient care.\n\nThe analysis revealed that the organizational logic in Swedish healthcare changed and that the physicians came in troubled positions as leaders. With management, workload, and risk repertoires, the physicians expressed that the organizational logic, to a large extent, was changed based on local contextual circumstances in the 21 self-governing regions. The organizational logic was being altered based upon how the two powerbases (physicians and managers) were interacting over time.\n\nGiven that healthcare probably will deal with future unforeseen crises, it seems essential that healthcare leaders discuss what can be a sustainable organizational logic. There should be more explicit regulatory elements about who is responsible for what in similar situations. The normative elements have probably been stretched during the ongoing crisis, given that physicians have gained practical experience and that there is now also, at least some evidence-based knowledge about this particular pandemic. But the question is what knowledge they need in their education when it comes to dealing with new unknown risks.", "doi": "10.1186/s12913-022-08094-z", "pmid": "35659289", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-022-08094-z"}], "notes": [], "created": "2022-06-21T17:18:03.286Z", "modified": "2022-06-21T17:18:03.302Z"}, {"entity": "publication", "iuid": "cffb2f3684df41d4a4afe77d5311fc77", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cffb2f3684df41d4a4afe77d5311fc77.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cffb2f3684df41d4a4afe77d5311fc77"}}, "title": "Epidemic risk perceptions in Italy and Sweden driven by authority responses to COVID-19.", "authors": [{"family": "Raffetti", "given": "Elena", "initials": "E"}, {"family": "Mondino", "given": "Elena", "initials": "E"}, {"family": "Di Baldassarre", "given": "Giuliano", "initials": "G"}], "type": "journal article", "published": "2022-06-03", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "9291", "issn-l": "2045-2322"}, "abstract": "Understanding public risk perception is an essential step to develop effective measures reducing the spread of disease outbreaks. Here we compare epidemic risk perceptions during two different periods of the COVID-19 pandemic in Italy and Sweden. To this end, we analyzed the results of two nationwide surveys carried out in both countries in two periods characterized by different infection rates: August (N = 4154) and November 2020 (N = 4168). Seven domains of epidemic risk perception were considered: likelihood along with (individual and population) impact, preparedness, and knowledge. The role of the context and period was explored in stratified and formal interaction analyses. In both countries, we found an intensification in epidemic risk perception from August to November 2020. Being male, older and having a higher relative income were associated with a lower perception of the likelihood of epidemics, while excess mortality was marginally related to higher odds. Compared to Sweden, Italy had a higher increase in perception of likelihood and impact, and a concurrent decrease in preparedness and knowledge. The different authority response to the COVID-19 pandemic is associated with a different change over time in risk perception. Regional differences in terms of excess mortality only marginally explained differences in risk perception.", "doi": "10.1038/s41598-022-13218-w", "pmid": "35662262", "labels": {"Type: Journal article": null, "Category: Health": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC9164564"}, {"db": "pii", "key": "10.1038/s41598-022-13218-w"}], "notes": [], "created": "2022-06-20T19:35:33.529Z", "modified": "2023-01-13T14:43:02.040Z"}, {"entity": "publication", "iuid": "0dd07c255c91411ca3447617601e604c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0dd07c255c91411ca3447617601e604c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0dd07c255c91411ca3447617601e604c"}}, "title": "Burden of Disease of COVID-19: Strengthening the Collaboration for National Studies.", "authors": [{"family": "Pires", "given": "Sara Monteiro", "initials": "SM"}, {"family": "Wyper", "given": "Grant M A", "initials": "GMA"}, {"family": "Wengler", "given": "Annelene", "initials": "A"}, {"family": "Pe\u00f1alvo", "given": "Jos\u00e9 L", "initials": "JL"}, {"family": "Haneef", "given": "Romana", "initials": "R"}, {"family": "Moran", "given": "Declan", "initials": "D"}, {"family": "Cuschieri", "given": "Sarah", "initials": "S"}, {"family": "Redondo", "given": "Hernan G", "initials": "HG"}, {"family": "De Pauw", "given": "Robby", "initials": "R"}, {"family": "McDonald", "given": "Scott A", "initials": "SA"}, {"family": "Moon", "given": "Lynelle", "initials": "L"}, {"family": "Shedrawy", "given": "Jad", "initials": "J"}, {"family": "Pallari", "given": "Elena", "initials": "E"}, {"family": "Charalampous", "given": "Periklis", "initials": "P"}, {"family": "Devleesschauwer", "given": "Brecht", "initials": "B"}, {"family": "Von Der Lippe", "given": "Elena", "initials": "E"}], "type": "journal article", "published": "2022-06-03", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "10", "pages": "907012", "issn-l": "2296-2565"}, "abstract": "Quantifying the combined impact of morbidity and mortality is a key enabler to assessing the impact of COVID-19 across countries and within countries relative to other diseases, regions, or demographics. Differences in methods, data sources, and definitions of mortality due to COVID-19 may hamper comparisons. We describe efforts to support countries in estimating the national-level burden of COVID-19 using disability-adjusted life years.\n\nThe European Burden of Disease Network developed a consensus methodology, as well as a range of capacity-building activities to support burden of COVID-19 studies. These activities have supported 11 national studies so far, with study periods between January 2020 and December 2021.\n\nNational studies dealt with various data gaps and different assumptions were made to face knowledge gaps. Still, they delivered broadly comparable results that allow for interpretation of consistencies, as well as differences in the quantified direct health impact of the pandemic.\n\nHarmonized efforts and methodologies have allowed for comparable estimates and communication of results. Future studies should evaluate the impact of interventions, and unravel the indirect health impact of the COVID-19 crisis.", "doi": "10.3389/fpubh.2022.907012", "pmid": "35734754", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC9208200"}], "notes": [], "created": "2022-08-19T05:52:02.531Z", "modified": "2022-08-19T05:52:02.544Z"}, {"entity": "publication", "iuid": "6b3231f157f94108849d7d57fd82e8a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b3231f157f94108849d7d57fd82e8a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b3231f157f94108849d7d57fd82e8a4"}}, "title": "The Karolinska KI/K COVID-19 Immune Atlas: An open resource for immunological research and educational purposes.", "authors": [{"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Ask", "given": "Eivind Heggernes", "initials": "EH", "orcid": "0000-0001-8655-1433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad160fa96dd94738a713f5c6934e61fa.json"}}, {"family": "Cornillet", "given": "Martin", "initials": "M"}, {"family": "Strunz", "given": "Benedikt", "initials": "B"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Rao Muvva", "given": "Jagadeeswara", "initials": "J"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Chambers", "given": "Benedict J", "initials": "BJ", "orcid": "0000-0003-0437-8441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6089d99ec42d475f8f57c8d8cc1ff1de.json"}}, {"family": "Cuapio", "given": "Angelica", "initials": "A", "orcid": "0000-0002-9451-1914", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f4915fdfa7d460f9b705b56b0fc1c4a.json"}}, {"family": "Dzidic", "given": "Majda", "initials": "M"}, {"family": "Filipovic", "given": "Iva", "initials": "I", "orcid": "0000-0002-8166-5500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c79974df90ae4fbf8be348b9b47d0317.json"}}, {"family": "Flodstr\u00f6m-Tullberg", "given": "Malin", "initials": "M"}, {"family": "Garcia", "given": "Marina", "initials": "M"}, {"family": "Gorin", "given": "Jean-Baptiste", "initials": "J"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Hertwig", "given": "Laura", "initials": "L"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Kokkinou", "given": "Efthymia", "initials": "E"}, {"family": "Kvedaraite", "given": "Egle", "initials": "E"}, {"family": "Lourda", "given": "Magda", "initials": "M"}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J"}, {"family": "Maucourant", "given": "Christopher", "initials": "C"}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A"}, {"family": "Palma Medina", "given": "Laura M", "initials": "LM"}, {"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Perez-Potti", "given": "Andr\u00e9", "initials": "A"}, {"family": "Ponzetta", "given": "Andrea", "initials": "A"}, {"family": "Ringqvist", "given": "Emma", "initials": "E"}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Sandberg", "given": "J Tyler", "initials": "JT"}, {"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "Svensson", "given": "Mattias", "initials": "M", "orcid": "0000-0003-1695-7934", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7ae76a597164d02b4fcfadfe53c48a3.json"}}, {"family": "Varnaite", "given": "Renata", "initials": "R"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Karolinska KI/K COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Malmberg", "given": "Karl-Johan", "initials": "K"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}], "type": "journal article", "published": "2022-06-02", "journal": {"title": "Scand J Immunol", "issn": "1365-3083", "issn-l": null, "volume": null, "issue": null, "pages": "e13195"}, "abstract": "The Karolinska KI/K COVID-19 Immune Atlas project was conceptualized in March 2020 as a part of the academic research response to the developing SARS-CoV-2 pandemic. The aim was to rapidly provide a curated dataset covering the acute immune response towards SARS-CoV-2 infection in humans, as it occurred during the first wave. The Immune Atlas was built as an open resource for broad research and educational purposes. It contains a presentation of the response evoked by different immune and inflammatory cells in defined na\u00efve patient-groups as they presented with moderate and severe COVID-19 disease. The present Resource Article describes how the Karolinska KI/K COVID-19 Immune Atlas allow scientists, students, and other interested parties to freely explore the nature of the immune response towards human SARS-CoV-2 infection in an online setting.", "doi": "10.1111/sji.13195", "pmid": "35652743", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Category: Other": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "URL", "key": "http://www.covid19cellatlas.com/", "description": "http://www.covid19cellatlas.com/"}], "notes": [], "created": "2022-06-21T17:25:20.401Z", "modified": "2022-06-21T17:31:07.574Z"}, {"entity": "publication", "iuid": "b0c9b466e4b145bb9cc631e82cf6011c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b0c9b466e4b145bb9cc631e82cf6011c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b0c9b466e4b145bb9cc631e82cf6011c"}}, "title": "The International Academy of Health Sciences Informatics: 2021 Update.", "authors": [{"family": "Hersh", "given": "William R", "initials": "WR"}, {"family": "Haux", "given": "Reinhold", "initials": "R"}, {"family": "Huesing", "given": "Elaine", "initials": "E"}, {"family": "Ball", "given": "Marion J", "initials": "MJ"}, {"family": "Kimura", "given": "Michio", "initials": "M"}, {"family": "Otero", "given": "Paula", "initials": "P"}, {"family": "Detmer", "given": "Don", "initials": "D"}, {"family": "Koch", "given": "Sabine", "initials": "S"}, {"family": "Saranto", "given": "Kaija K", "initials": "KK"}, {"family": "Wright", "given": "Graham", "initials": "G"}], "type": "journal article", "published": "2022-06-02", "journal": {"title": "Yearb Med Inform", "issn": "2364-0502", "issn-l": null}, "abstract": "To summarize the activities of the International Academy of Health Sciences Informatics (IAHSI) in 2021 and welcome its 2021 Class of Fellows.\n\nReport on governance, strategic directions, newly elected fellows, plenary meetings, and other activities of the Academy.\n\nAs in 2020, all of the Academy's activities were carried out virtually due to the COVID-19 pandemic. In 2021, new Board members were elected. Strategic activities in data standards and interoperability and in mentorship moved forward. A new class of 26 Fellows was elected, bringing the total membership of the Academy to 204 Fellows from all regions of the world. In addition, a virtual plenary meeting was held.\n\nThe Academy has continued to pursue its role as the honorific society globally for biomedical and health informatics. Expansion of strategic activities and membership will continue moving forward.", "doi": "10.1055/s-0042-1742501", "pmid": "35654427", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T17:20:41.316Z", "modified": "2022-06-21T17:20:41.329Z"}, {"entity": "publication", "iuid": "b8b02774a6a744df875d0f9e1a91c944", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8b02774a6a744df875d0f9e1a91c944.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8b02774a6a744df875d0f9e1a91c944"}}, "title": "No learning loss in Sweden during the pandemic evidence from primary school reading assessments.", "authors": [{"family": "Hallin", "given": "Anna Eva", "initials": "AE"}, {"family": "Danielsson", "given": "Henrik", "initials": "H"}, {"family": "Nordstr\u00f6m", "given": "Thomas", "initials": "T"}, {"family": "F\u00e4lth", "given": "Linda", "initials": "L"}], "type": "journal article", "published": "2022-06-02", "journal": {"title": "Int J Educ Res", "issn": "0883-0355", "issn-l": null, "volume": "114", "issue": null, "pages": "102011"}, "abstract": "The COVID-19 pandemic has led to worldwide school closures, with a risk of learning loss. Sweden kept primary schools open, but it is unknown whether student and teacher absence and pandemic-related stress factors affected teaching and student progress negatively. In this study, reading assessment data from 97,073 Swedish primary school students (grades 1-3) were analysed to investigate potential learning loss. Results showed that word decoding and reading comprehension scores were not lower during the pandemic compared to before the pandemic, that students from low socio-economic backgrounds were not especially affected, and that the proportion of students with weak decoding skills did not increase during the pandemic. Study limitations are discussed. We conclude that open schools benefitted Swedish primary school students.", "doi": "10.1016/j.ijer.2022.102011", "pmid": "35677729", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0883-0355(22)00089-1"}, {"db": "pmc", "key": "PMC9162440"}], "notes": [], "created": "2022-06-20T19:31:04.068Z", "modified": "2022-11-09T08:42:18.260Z"}, {"entity": "publication", "iuid": "8ecf67a8c27045238eed362c6919a052", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ecf67a8c27045238eed362c6919a052.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ecf67a8c27045238eed362c6919a052"}}, "title": "Integration of systematic screening for tuberculosis in outpatient departments of urban primary healthcare facilities in Zambia: a case study of Kitwe district.", "authors": [{"family": "Zulu", "given": "Davy Wadula", "initials": "DW"}, {"family": "Silumbwe", "given": "Adam", "initials": "A"}, {"family": "Maritim", "given": "Patricia", "initials": "P"}, {"family": "Zulu", "given": "Joseph Mumba", "initials": "JM"}], "type": "journal article", "published": "2022-06-02", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "volume": "22", "issue": "1", "pages": "732", "issn-l": null}, "abstract": "Tuberculosis (TB) is the leading cause of death from a single infectious agent globally, killing about 1.5 million people annually, yet 3 million cases are missed every year. The World Health Organization recommends systematic screening of suspected active TB patients among those visiting the healthcare facilities. While many countries have scaled-up systematic screening of TB, there has been limited assessment of the extent of its integration into the health system. This study sought to explore factors that shape the integration of systematic screening of TB in outpatient departments of primary healthcare facilities in Kitwe district, Zambia.\n\nThis was a qualitative case study with health providers including district managers, TB focal point persons and laboratory personnel working in six purposively selected primary healthcare facilities. Data was collected through key informant (n = 8) and in-depth (n = 15) interviews. Data analysis was conducted using QDA Miner software and guided by Atun's Integration framework.\n\nThe facilitators to integration of systematic screening for TB into out patient departments of primary health facilities included the perceived high burden TB, compatibility of the systematic screening for TB program with healthcare workers training and working schedules, stakeholder knowledge of each others interest and values, regular performance management and integrated outreach of TB screening services. Constraining factors to integration of systematic screening for TB into outpatient departments included complexity of screening for TB in children, unbalanced incentivization mechanisms, ownership and legitimacy of the TB screening program, negative health worker attitudes, social cultural misconceptions of TB and societal stigma as well as the COVID-19 pandemic.\n\nSystematic screening of TB is not fully integrated into the primary healthcare facilities in Zambia to capture all those suspected with active TB that make contact with the health system. Finding the missing TB cases will, therefore, require contextual adaptation of the systematic screening for TB program to local needs and capacities as well as strengthening the health system.", "doi": "10.1186/s12913-022-08043-w", "pmid": "35655301", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-022-08043-w"}], "notes": [], "created": "2022-06-21T17:20:22.124Z", "modified": "2022-06-21T17:20:22.136Z"}, {"entity": "publication", "iuid": "6cca6c1a8846428ba8ad2030031ab08e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6cca6c1a8846428ba8ad2030031ab08e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6cca6c1a8846428ba8ad2030031ab08e"}}, "title": "Changes in Brain-Health Related Modifiable Risk Factors in Older Adults After One Year of COVID-19-Restrictions.", "authors": [{"family": "Waterink", "given": "Lisa", "initials": "L"}, {"family": "Bakker", "given": "Els D", "initials": "ED"}, {"family": "Visser", "given": "Leonie N C", "initials": "LNC"}, {"family": "Mangialasche", "given": "Francesca", "initials": "F"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Deckers", "given": "Kay", "initials": "K"}, {"family": "K\u00f6hler", "given": "Sebastian", "initials": "S"}, {"family": "Sikkes", "given": "Sietske A M", "initials": "SAM"}, {"family": "Prins", "given": "Niels D", "initials": "ND"}, {"family": "Scheltens", "given": "Philip", "initials": "P"}, {"family": "van der Flier", "given": "Wiesje M", "initials": "WM"}, {"family": "Zwan", "given": "Marissa D", "initials": "MD"}], "type": "journal article", "published": "2022-06-02", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "13", "pages": "877460", "issn-l": "1664-0640"}, "abstract": "The COVID-19 pandemic has major influence on lifestyle and mental health, which might affect brain-health and increase the risk of cognitive decline, particularly in older adults. We aimed to describe changes in modifiable risk factors related to brain-health in older adults after one year of COVID-19 restrictions.\n\nAn online survey was disseminated between February and March 2021 to 17,773 registrants of the Dutch Brain Research Registry, aged \u226550, without a self-reported diagnosis of mild cognitive impairment or dementia. Participants were asked to report potential changes in behaviors during the COVID-19 pandemic, compared to pre-pandemic, in eight domains related to brain health: physical activity, sleep, feeling of memory decline, perceived stress, feeling of loneliness, diet, alcohol consumption, and smoking. We used negative binomial regression analyses to relate (socio)demographics, subjective memory complaints and COVID-19 related aspects (fear of, or current/past COVID-19 infection) to the number of reported detrimental and beneficial changes as dependent variable.\n\n3,943 participants (66 \u00b1 8 years old; 76% female; 71% highly educated) completed the survey. After one year of COVID-19-restrictions, 74% reported at least one detrimental lifestyle change unfavorable for their brain health, most frequently reported were feelings of loneliness, sleep problems, and less physical activity. 60% of participants reported at least one beneficial change, which were most often more physical activity, healthier dietary habits, and less alcohol consumption. Individuals who are younger [incidence rate ratio (IRR) = 0.99, 95% CI = 0.98-0.99], female (1.20, 1.11-1.30), living alone (1.20, 1.11-1.28) and in urban environments (1.18, 1.08-1.29), who are less satisfied with their income (1.38, 1.17-1.62), experiencing subjective memory complaints (1.40, 1.28-1.52) and those with a past or current (1.19, 1.06-1.34) or fear of a COVID-19 infection (1.33, 1.25-1.42) reported higher numbers of detrimental changes.\n\nThe COVID-19 pandemic has influenced lifestyle in both positive and negative ways. We identified (socio)demographic factors associated with more detrimental changes in modifiable risk factors related to brain health, suggesting that some individuals are more vulnerable for the impact of the COVID-19 pandemic. These findings provide an opportunity for targeted prevention and education to promote a healthy lifestyle during and after the pandemic.", "doi": "10.3389/fpsyt.2022.877460", "pmid": "35722572", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9201112"}], "notes": [], "created": "2022-06-20T18:04:12.788Z", "modified": "2022-08-17T12:45:33.702Z"}, {"entity": "publication", "iuid": "9cd5cf69381f4d3196ee195a00a48d84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9cd5cf69381f4d3196ee195a00a48d84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9cd5cf69381f4d3196ee195a00a48d84"}}, "title": "A Network Analysis of the Fear of COVID-19 Scale (FCV-19S): A Large-Scale Cross-Cultural Study in Iran, Bangladesh, and Norway.", "authors": [{"family": "Lecuona", "given": "Oscar", "initials": "O", "orcid": "0000-0003-0080-1062", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3c84f17b7bf4210aa39eeb252d8bd33.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Rozgonjuk", "given": "Dmitri", "initials": "D"}, {"family": "Norekv\u00e5l", "given": "Tone M", "initials": "TM"}, {"family": "Iversen", "given": "Marjolein M", "initials": "MM"}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA", "orcid": "0000-0002-1728-8966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6e65a5a97154d159a63cc2ce3f1b7a8.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Lin", "given": "Ting-I", "initials": "TI"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2022-06-02", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "11", "issn-l": null}, "abstract": "The rapid spread of the coronavirus disease 2019 (COVID-19) has led to high levels of fear worldwide. Given that fear is an important factor in causing psychological distress and facilitating preventive behaviors, assessing the fear of COVID-19 is important. The seven-item Fear of COVID-19 Scale (FCV-19S) is a widely used psychometric instrument to assess this fear. However, the factor structure of the FCV-19S remains unclear according to the current evidence. Therefore, the present study used a network analysis to provide further empirical evidence for the factor structure of FCV-19S. A total of 24,429 participants from Iran (n = 10,843), Bangladesh (n = 9906), and Norway (n = 3680) completed the FCV-19S in their local language. A network analysis (via regularized partial correlation networks) was applied to investigate the seven FCV-19S items. Moreover, relationships between the FCV-19S items were compared across gender (males vs. females), age groups (18-30 years, 31-50 years, and &gt;50 years), and countries (Iran, Bangladesh, and Norway). A two-factor structure pattern was observed (three items concerning physical factors, including clammy hands, insomnia, and heart palpitations; four items concerning psychosocial factors, including being afraid, uncomfortable, afraid of dying, and anxious about COVID-19 news). Moreover, this pattern was found to be the same among men and women, across age groups and countries. The network analysis used in the present study verified the two-factor structure for the FCV-19S. Future studies may consider using the two-factor structure of FCV-19S to assess the fear of COVID-19 during the COVID-19 era.", "doi": "10.3390/ijerph19116824", "pmid": "35682405", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19116824"}], "notes": [], "created": "2022-06-20T19:27:26.888Z", "modified": "2022-06-20T19:27:26.996Z"}, {"entity": "publication", "iuid": "f479e90cff3441c792c233351414db88", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f479e90cff3441c792c233351414db88.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f479e90cff3441c792c233351414db88"}}, "title": "Remote investigation and assessment of vital signs (RIA-VS)-proof of concept for contactless estimation of blood pressure, pulse, respiratory rate, and oxygen saturation in patients with suspicion of COVID-19.", "authors": [{"family": "Malmberg", "given": "Stefan", "initials": "S"}, {"family": "Khan", "given": "Taha", "initials": "T"}, {"family": "Gunnarsson", "given": "Ronny", "initials": "R", "orcid": "0000-0001-9183-3072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f25154a31c304d23bb9d37ec121eedd2.json"}}, {"family": "Jacobsson", "given": "Gunnar", "initials": "G"}, {"family": "Sundvall", "given": "P\u00e4r-Daniel", "initials": "PD"}], "type": "journal article", "published": "2022-06-01", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "pages": "1-10", "issn-l": "2374-4235"}, "abstract": "Vital signs are critical in assessing the severity and prognosis of infections, for example, COVID-19, influenza, sepsis, and pneumonia. This study aimed to evaluate a new method for rapid camera-based non-contact measurement of heart rate, blood oxygen saturation, respiratory rate, and blood pressure.\n\nConsecutive adult patients attending a hospital emergency department for suspected COVID-19 infection were invited to participate. Vital signs measured with a new camera-based method were compared to the corresponding standard reference methods. The camera device observed the patient's face for 30 s from \u223c1 m.\n\nBetween 1 April and 1 October 2020, 214 subjects were included in the trial, 131 female (61%) and 83 male (39%). The mean age was 44 years (range 18-81 years). The new camera-based device's vital signs measurements were, on average, very close to the gold standard but the random variation was larger than the reference methods.\n\nThe principle of contactless measurement of blood pressure, pulse, respiratory rate, and oxygen saturation works, which is very promising. However, technical improvements to the equipment used in this study to reduce its random variability is required before clinical implementation. This will likely be a game changer once this is sorted out.\n\nUniversal Trial Number (UTN) U1111-1251-4114 and the ClinicalTrials.gov Identifier NCT04383457.", "doi": "10.1080/23744235.2022.2080249", "pmid": "35651319", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT04383457"}], "notes": [], "created": "2022-06-21T17:31:18.532Z", "modified": "2022-06-21T17:31:18.615Z"}, {"entity": "publication", "iuid": "b69f6910420f46ae80cc4a4072f8d2c4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b69f6910420f46ae80cc4a4072f8d2c4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b69f6910420f46ae80cc4a4072f8d2c4"}}, "title": "Missed nursing care in the critical care unit, before and during the COVID-19 pandemic: A comparative cross-sectional study.", "authors": [{"family": "Falk", "given": "Ann-Charlotte", "initials": "AC"}, {"family": "Nymark", "given": "Carolin", "initials": "C"}, {"family": "G\u00f6ransson", "given": "Katarina E", "initials": "KE"}, {"family": "von Vogelsang", "given": "Ann-Christin", "initials": "AC"}], "type": "journal article", "published": "2022-06-01", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "pages": "103276", "issn-l": null}, "abstract": "Todescribe and evaluate reported missed nursing care in the critical care context during different phases of the COVID-19 pandemic in Sweden.\n\nA comparative cross-sectional design was used, comparing missed nursing care in three samples: before the COVID-19 pandemic in 2019, during the second wave of the pandemic in spring 2020, and during the third wave of the pandemic in fall 2021.\n\nThe study was conducted at critical care units at a university hospital, Sweden.\n\nThe MISSCARE Survey-Swedish version was used to collect data along with two study-specific questions concerning perception of patient safety and quality of care.\n\nSignificantly more overtime hours and number of days absent due to illness were reported during the pandemic. The nurse/patient ratio was above the recommended level at all data collection time points. Most missed nursing care was reported in items concerning basic care. The most reported reasons for missed nursing care in all samples concerned inadequate staffing, urgent situations, and a rise in patient volume. Most nurses in all samples perceived the level of patient safety and quality of care as good, and the majority had no intention to leave their current position.\n\nThe pandemic had a great impact on the critical care workforce but few elements of missed nursing care were affected. To measure and use missed nursing care as a quality indicator could be valuable for nursing managers, to inform them and improve their ability to meet changes in patient needs with different workforce approaches in critical care settings.", "doi": "10.1016/j.iccn.2022.103276", "pmid": "35672210", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(22)00079-9"}], "notes": [], "created": "2022-06-20T19:31:47.138Z", "modified": "2022-06-20T19:31:56.430Z"}, {"entity": "publication", "iuid": "d6bb41724d964351a7463e2ac105f5f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d6bb41724d964351a7463e2ac105f5f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d6bb41724d964351a7463e2ac105f5f7"}}, "title": "Discovery of a Novel Coronavirus in Swedish Bank Voles (Myodes glareolus).", "authors": [{"family": "Wasberg", "given": "Anishia", "initials": "A"}, {"family": "Raghwani", "given": "Jayna", "initials": "J"}, {"family": "Li", "given": "Jinlin", "initials": "J"}, {"family": "Pettersson", "given": "John H-O", "initials": "JH"}, {"family": "Lindahl", "given": "Johanna F", "initials": "JF"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}], "type": "journal article", "published": "2022-06-01", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "6", "issn-l": "1999-4915"}, "abstract": "The unprecedented pandemic COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with bats as original reservoirs, has once again highlighted the importance of exploring the interface of wildlife diseases and human health. In this study, we identified a novel Betacoronavirus from bank voles (Myodes glareolus) in Grims\u00f6, Sweden, and this virus is designated as Grimso virus. Repeated detection over three years and an overall prevalence of 3.4% suggest that the virus commonly occurs in bank voles. Furthermore, phylogenetic analyses indicate that the Grimso virus belongs to a highly divergent Embecovirus lineage predominantly associated with bank voles. Given that bank voles are one of the most common rodent species in Sweden and Europe, our findings indicate that Grimso virus might be circulating widely in bank voles and further point out the importance of sentinel surveillance of coronaviruses in wild small mammalian animals, especially in wild rodents.", "doi": "10.3390/v14061205", "pmid": "35746677", "labels": {"Category: Biochemistry": null, "Research Area: Pandemic preparedness": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "v14061205"}, {"db": "pmc", "key": "PMC9230040"}], "notes": [], "created": "2022-08-19T05:41:46.521Z", "modified": "2022-08-19T05:43:22.484Z"}, {"entity": "publication", "iuid": "0ff90e6d55554880898f48eeadecda4f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ff90e6d55554880898f48eeadecda4f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ff90e6d55554880898f48eeadecda4f"}}, "title": "COVID-19 vaccines coverage and effectiveness against SARS-CoV-2 infection among residents in the largest Health Authority of Lazio region (Italy): a population-based cohort study.", "authors": [{"family": "Fano", "given": "Valeria", "initials": "V", "orcid": "0000-0003-1396-4928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39fbb5a6eee549c9b1cc336f36e8715c.json"}}, {"family": "Coviello", "given": "Enzo", "initials": "E", "orcid": "0000-0002-8396-2306", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c990efa224a4fc58ef9c318cbfe9541.json"}}, {"family": "Consonni", "given": "Dario", "initials": "D", "orcid": "0000-0002-8935-3843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f533ba417cb4950b77f0b4be5ad8f97.json"}}, {"family": "Agresta", "given": "Alessandro", "initials": "A", "orcid": "0000-0001-8890-0342", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/516cab6c029742b4a037b0f3478df969.json"}}, {"family": "Orsini", "given": "Nicola", "initials": "N", "orcid": "0000-0002-2210-5634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6161818f1f74a26883d3b1e37e72f2e.json"}}, {"family": "Crielesi", "given": "Alessia", "initials": "A"}, {"family": "Miglietta", "given": "Antonio Salvatore", "initials": "AS"}, {"family": "Pasqua", "given": "Caterina", "initials": "C"}, {"family": "Vairo", "given": "Francesco", "initials": "F", "orcid": "0000-0002-8375-7468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d99df4cf90cf43df92915c18d8b97e06.json"}}, {"family": "Vivaldi", "given": "Fabio", "initials": "F"}, {"family": "De Angelis", "given": "Giuseppe", "initials": "G"}, {"family": "Colaiocco", "given": "Giovanni", "initials": "G"}, {"family": "Fabiani", "given": "Massimo", "initials": "M", "orcid": "0000-0002-5893-7117", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6edd0048b0204f43972a2cb3dc08518d.json"}}], "type": "journal article", "published": "2022-06-01", "journal": {"title": "Expert Rev Vaccines", "issn": "1744-8395", "pages": "1-11", "issn-l": null}, "abstract": "The waning of the protective effect of COVID-19 vaccines and timing of booster doses are debated.\n\nPopulation-based cohort study in the largest Health-Authority of Lazio region, Italy, on 946,156 residents aged 12+ (study period: 1 January 2021-10 January 2022). Vaccine effectiveness (VE) against any SARS-CoV-2 infection (symptomatic or asymptomatic) was estimated through multivariable negative-binomial models using unvaccinated person-time as a reference.\n\nThe primary vaccination cycle was completed by 81% of residents; of these, 45% received a booster dose. Vaccine coverages were lower for foreigners, and people living in deprived areas, families with children aged 0-11, and households size 1 or 6+. Overall, VE waned from 71% (95% Confidence Interval (CI) 70-73%) 1 month after the second dose to 43% (CI 41-45%) after 4 months and 24% (CI 21-27%) after 6 months, especially in the elderly aged 70+. We observed a prompt restore of VE 15-19 days after the booster dose (69%, CI 67-70%).\n\nOur results support the recommendation of a booster dose 4 months after completion of the primary cycle, giving priority to elderly and fragile individuals. The lower vaccine coverage among social disadvantaged subgroups suggests the need of targeted communication and interventions.", "doi": "10.1080/14760584.2022.2080057", "pmid": "35584901", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T18:02:42.371Z", "modified": "2022-06-21T18:02:58.354Z"}, {"entity": "publication", "iuid": "28ed47e1513143fea34a4e0061bcd804", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/28ed47e1513143fea34a4e0061bcd804.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/28ed47e1513143fea34a4e0061bcd804"}}, "title": "Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double-blind, randomised, controlled, phase 3 trial.", "authors": [{"family": "Upton", "given": "Caryn M", "initials": "CM"}, {"family": "van Wijk", "given": "Rob C", "initials": "RC"}, {"family": "Mockeliunas", "given": "Laurynas", "initials": "L"}, {"family": "Simonsson", "given": "Ulrika S H", "initials": "USH"}, {"family": "McHarry", "given": "Kirsten", "initials": "K"}, {"family": "van den Hoogen", "given": "Gerben", "initials": "G"}, {"family": "Muller", "given": "Chantal", "initials": "C"}, {"family": "von Delft", "given": "Arn\u00e9", "initials": "A"}, {"family": "van der Westhuizen", "given": "Helene-Mari", "initials": "HM"}, {"family": "van Crevel", "given": "Reinout", "initials": "R"}, {"family": "Walzl", "given": "Gerhard", "initials": "G"}, {"family": "Baptista", "given": "Pedro M", "initials": "PM"}, {"family": "Peter", "given": "Jonathan", "initials": "J"}, {"family": "Diacon", "given": "Andreas H", "initials": "AH"}, {"family": "BCG CORONA Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": "48", "pages": "101414", "issn-l": null}, "abstract": "BCG vaccination prevents severe childhood tuberculosis (TB) and was introduced in South Africa in the 1950s. It is hypothesised that BCG trains the innate immune system by inducing epigenetic and functional reprogramming, thus providing non-specific protection from respiratory tract infections. We evaluated BCG for reduction of morbidity and mortality due to COVID-19 in healthcare workers in South Africa.\n\nThis randomised, double-blind, placebo-controlled trial recruited healthcare workers at three facilities in the Western Cape, South Africa, unless unwell, pregnant, breastfeeding, immunocompromised, hypersensitivity to BCG, or undergoing experimental COVID-19 treatment. Participants received BCG or saline intradermally (1:1) and were contacted once every 4 weeks for 1 year. COVID-19 testing was guided by symptoms. Hospitalisation, COVID-19, and respiratory tract infections were assessed with Cox proportional hazard modelling and time-to-event analyses, and event severity with post hoc Markovian analysis. This study is registered with ClinicalTrials.gov, NCT04379336.\n\nBetween May 4 and Oct 23, 2020, we enrolled 1000 healthcare workers with a median age of 39 years (IQR 30-49), 70\u00b74% were female, 16\u00b75% nurses, 14\u00b74% medical doctors, 48\u00b75% had latent TB, and 15\u00b73% had evidence of prior SARS-CoV-2 exposure. Hospitalisation due to COVID-19 occurred in 15 participants (1\u00b75%); ten (66\u00b77%) in the BCG group and five (33\u00b73%) in the placebo group, hazard ratio (HR) 2\u00b70 (95% CI 0\u00b769-5\u00b79, p = 0\u00b720), indicating no statistically significant protection. Similarly, BCG had no statistically significant effect on COVID-19 (p = 0\u00b763, HR = 1\u00b708, 95% CI 0\u00b782-1\u00b742). Two participants (0\u00b72%) died from COVID-19 and two (0\u00b72%) from other reasons, all in the placebo group.\n\nBCG did not protect healthcare workers from SARS-CoV-2 infection or related severe COVID-19 disease and hospitalisation.\n\nFunding provided by EDCTP, grant number RIA2020EF-2968. Additional funding provided by private donors including: Mediclinic, Calavera Capital (Pty) Ltd, Thys Du Toit, Louis Stassen, The Ryan Foundation, and Dream World Investments 401 (Pty) Ltd. The computations were enabled by resources in project SNIC 2020-5-524 provided by the Swedish National Infrastructure for Computing (SNIC) at UPPMAX, partially funded by the Swedish Research Council through grant agreement No. 2018-05,973.", "doi": "10.1016/j.eclinm.2022.101414", "pmid": "35582122", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(22)00144-4"}, {"db": "pmc", "key": "PMC9098089"}, {"db": "ClinicalTrials.gov", "key": "NCT04379336"}], "notes": [], "created": "2022-06-21T18:04:16.071Z", "modified": "2022-06-21T18:04:16.083Z"}, {"entity": "publication", "iuid": "c5f19680051c403ea6589f082ed762df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5f19680051c403ea6589f082ed762df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5f19680051c403ea6589f082ed762df"}}, "title": "SARS-CoV-2 Omicron variants BA.1 and BA.2 both show similarly reduced disease severity of COVID-19 compared to Delta, Germany, 2021 to 2022.", "authors": [{"family": "Sievers", "given": "Claudia", "initials": "C"}, {"family": "Zacher", "given": "Benedikt", "initials": "B"}, {"family": "Ullrich", "given": "Alexander", "initials": "A"}, {"family": "Huska", "given": "Matthew", "initials": "M"}, {"family": "Fuchs", "given": "Stephan", "initials": "S"}, {"family": "Buda", "given": "Silke", "initials": "S"}, {"family": "Haas", "given": "Walter", "initials": "W"}, {"family": "Diercke", "given": "Michaela", "initials": "M"}, {"family": "An der Heiden", "given": "Matthias", "initials": "M"}, {"family": "Kr\u00f6ger", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "27", "issue": "22", "issn-l": null}, "abstract": "German national surveillance data analysis shows that hospitalisation odds associated with Omicron lineage BA.1 or BA.2 infections are up to 80% lower than with Delta infection, primarily in \u2265 35-year-olds. Hospitalised vaccinated Omicron cases' proportions (2.3% for both lineages) seemed lower than those of the unvaccinated (4.4% for both lineages). Independent of vaccination status, the hospitalisation frequency among cases with Delta seemed nearly threefold higher (8.3%) than with Omicron (3.0% for both lineages), suggesting that Omicron inherently causes less severe disease.", "doi": "10.2807/1560-7917.ES.2022.27.22.2200396", "pmid": "35656831", "labels": {"Category: Omicron VoC": null, "Type: Journal article": null, "Category: Health": null, "Category: Genomics & transcriptomics": null}, "xrefs": [], "notes": [], "created": "2022-06-21T17:18:36.850Z", "modified": "2022-06-21T17:18:55.633Z"}, {"entity": "publication", "iuid": "a33a47868288439ebae157b0221bb4f5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a33a47868288439ebae157b0221bb4f5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a33a47868288439ebae157b0221bb4f5"}}, "title": "Risk of SARS-CoV-2 reinfection and COVID-19 hospitalisation in individuals with natural and hybrid immunity: a retrospective, total population cohort study in Sweden.", "authors": [{"family": "Nordstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Ballin", "given": "Marcel", "initials": "M"}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "volume": "22", "issue": "6", "pages": "781-790", "issn-l": null}, "abstract": "Real-world evidence supporting vaccination against COVID-19 in individuals who have recovered from a previous SARS-CoV-2 infection is sparse. We aimed to investigate the long-term protection from a previous infection (natural immunity) and whether natural immunity plus vaccination (hybrid immunity) was associated with additional protection.\n\nIn this retrospective cohort study, we formed three cohorts using Swedish nationwide registers managed by the Public Health Agency of Sweden, the National Board of Health and Welfare, and Statistics Sweden. Cohort 1 included unvaccinated individuals with natural immunity matched pairwise on birth year and sex to unvaccinated individuals without natural immunity at baseline. Cohort 2 and cohort 3 included individuals vaccinated with one dose (one-dose hybrid immunity) or two doses (two-dose hybrid immunity) of a COVID-19 vaccine, respectively, after a previous infection, matched pairwise on birth year and sex to individuals with natural immunity at baseline. Outcomes of this study were documented SARS-CoV-2 infection from March 20, 2020, until Oct 4, 2021, and inpatient hospitalisation with COVID-19 as main diagnosis from March 30, 2020, until Sept 5, 2021.\n\nCohort 1 was comprised of 2 039 106 individuals, cohort 2 of 962 318 individuals, and cohort 3 of 567 810 individuals. During a mean follow-up of 164 days (SD 100), 34 090 individuals with natural immunity in cohort 1 were registered as having had a SARS-CoV-2 reinfection compared with 99 168 infections in non-immune individuals; the numbers of hospitalisations were 3195 and 1976, respectively. After the first 3 months, natural immunity was associated with a 95% lower risk of SARS-CoV-2 infection (adjusted hazard ratio [aHR] 0\u00b705 [95% CI 0\u00b705-0\u00b705] p<0\u00b7001) and an 87% (0\u00b713 [0\u00b711-0\u00b716]; p<0\u00b7001) lower risk of COVID-19 hospitalisation for up to 20 months of follow-up. During a mean follow-up of 52 days (SD 38) in cohort 2, 639 individuals with one-dose hybrid immunity were registered with a SARS-CoV-2 reinfection, compared with 1662 individuals with natural immunity (numbers of hospitalisations were eight and 113, respectively). One-dose hybrid immunity was associated with a 58% lower risk of SARS-CoV-2 reinfection (aHR 0\u00b742 [95% CI 0\u00b738-0\u00b747]; p<0\u00b7001) than natural immunity up to the first 2 months, with evidence of attenuation thereafter up to 9 months (p<0\u00b7001) of follow-up. During a mean follow-up of 66 days (SD 53) in cohort 3, 438 individuals with two-dose hybrid immunity were registered as having had a SARS-CoV-2 reinfection, compared with 808 individuals with natural immunity (numbers of hospitalisations were six and 40, respectively). Two-dose hybrid immunity was associated with a 66% lower risk of SARS-CoV-2 reinfection (aHR 0\u00b734 [95% CI 0\u00b731-0\u00b739]; p<0\u00b7001) than natural immunity, with no significant attenuation up to 9 months (p=0\u00b707). To prevent one reinfection in the natural immunity cohort during follow-up, 767 individuals needed to be vaccinated with two doses. Both one-dose (HR adjusted for age and baseline date 0\u00b706 [95% CI 0\u00b703-0\u00b712]; p<0\u00b7001) and two-dose (HR adjusted for age and baseline date 0\u00b710 [0\u00b704-0\u00b722]; p<0\u00b7001) hybrid immunity were associated with a lower risk of COVID-19 hospitalisation than natural immunity.\n\nThe risk of SARS-CoV-2 reinfection and COVID-19 hospitalisation in individuals who have survived and recovered from a previous infection remained low for up to 20 months. Vaccination seemed to further decrease the risk of both outcomes for up to 9 months, although the differences in absolute numbers, especially in hospitalisations, were small. These findings suggest that if passports are used for societal restrictions, they should acknowledge either a previous infection or vaccination as proof of immunity, as opposed to vaccination only.\n\nNone.", "doi": "10.1016/S1473-3099(22)00143-8", "pmid": "35366962", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8971363"}, {"db": "pii", "key": "S1473-3099(22)00143-8"}], "notes": [], "created": "2022-04-04T06:21:49.284Z", "modified": "2023-07-13T11:28:04.534Z"}, {"entity": "publication", "iuid": "8151ff7d54534086a1eb2b358c68a32d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8151ff7d54534086a1eb2b358c68a32d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8151ff7d54534086a1eb2b358c68a32d"}}, "title": "Rapidly adapting primary care sentinel surveillance across seven countries in Europe for COVID-19 in the first half of 2020: strengths, challenges, and lessons learned.", "authors": [{"family": "Bagaria", "given": "Jayshree", "initials": "J"}, {"family": "Jansen", "given": "Tessa", "initials": "T"}, {"family": "Marques", "given": "Diogo Fp", "initials": "DF"}, {"family": "Hooiveld", "given": "Mariette", "initials": "M"}, {"family": "McMenamin", "given": "Jim", "initials": "J"}, {"family": "de Lusignan", "given": "Simon", "initials": "S"}, {"family": "Vilcu", "given": "Ana-Maria", "initials": "AM"}, {"family": "Meijer", "given": "Adam", "initials": "A"}, {"family": "Rodrigues", "given": "Ana-Paula", "initials": "AP"}, {"family": "Brytting", "given": "Mia", "initials": "M"}, {"family": "Mazagatos", "given": "Clara", "initials": "C"}, {"family": "Cogdale", "given": "Jade", "initials": "J"}, {"family": "van der Werf", "given": "Sylvie", "initials": "S"}, {"family": "Dijkstra", "given": "Frederika", "initials": "F"}, {"family": "Guiomar", "given": "Raquel", "initials": "R"}, {"family": "Enkirch", "given": "Theresa", "initials": "T"}, {"family": "Valenciano", "given": "Marta", "initials": "M"}, {"family": "I-MOVE-COVID-19 study team", "given": "", "initials": ""}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "27", "issue": "26", "issn-l": null}, "abstract": "As the COVID-19 pandemic began in early 2020, primary care influenza sentinel surveillance networks within the Influenza - Monitoring Vaccine Effectiveness in Europe (I-MOVE) consortium rapidly adapted to COVID-19 surveillance. This study maps system adaptations and lessons learned about aligning influenza and COVID-19 surveillance following ECDC / WHO/Europe recommendations and preparing for other diseases possibly emerging in the future. Using a qualitative approach, we describe the adaptations of seven sentinel sites in five European Union countries and the United Kingdom during the first pandemic phase (March-September 2020). Adaptations to sentinel systems were substantial (2/7 sites), moderate (2/7) or minor (3/7 sites). Most adaptations encompassed patient referral and sample collection pathways, laboratory testing and data collection. Strengths included established networks of primary care providers, highly qualified testing laboratories and stakeholder commitments. One challenge was the decreasing number of samples due to altered patient pathways. Lessons learned included flexibility establishing new routines and new laboratory testing. To enable simultaneous sentinel surveillance of influenza and COVID-19, experiences of the sentinel sites and testing infrastructure should be considered. The contradicting aims of rapid case finding and contact tracing, which are needed for control during a pandemic and regular surveillance, should be carefully balanced.", "doi": "10.2807/1560-7917.ES.2022.27.26.2100864", "pmid": "35775429", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9248262"}], "notes": [], "created": "2022-08-17T13:12:39.666Z", "modified": "2022-08-17T13:12:39.680Z"}, {"entity": "publication", "iuid": "21ddc26f77ed4aa39fe287b3b80f6cc8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/21ddc26f77ed4aa39fe287b3b80f6cc8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/21ddc26f77ed4aa39fe287b3b80f6cc8"}}, "title": "Prevalence of gaming addiction and its impact on sleep quality: A cross-sectional study from Pakistan.", "authors": [{"family": "Zaman", "given": "Musharaf", "initials": "M"}, {"family": "Babar", "given": "Muhammad Saad", "initials": "MS"}, {"family": "Babar", "given": "Maryam", "initials": "M"}, {"family": "Sabir", "given": "Faheem", "initials": "F"}, {"family": "Ashraf", "given": "Farzana", "initials": "F"}, {"family": "Tahir", "given": "Muhammad Junaid", "initials": "MJ"}, {"family": "Ullah", "given": "Irfan", "initials": "I"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Ann Med Surg (Lond)", "issn": "2049-0801", "volume": "78", "pages": "103641", "issn-l": null}, "abstract": "Gaming addiction has become a topic of increasing research interest worldwide but little research has been carried out in Pakistan.\n\nThe present study assessed the prevalence of gaming addiction among a Pakistani sample of adults in the general population. It also explored the effects of online gaming addiction upon sleep quality.\n\nA cross-sectional survey was carried out during a national lockdown due to the COVID-19 pandemic in Pakistan. Using a convenience sampling technique, an online survey comprising demographic information, the Game Addiction Scale (GAS), and the Pittsburgh Sleep Quality Index (PSQI) was completed by 618 participants (67.5% male) aged 18-56 years (M = 24.53 years, SD = \u00b15.016).\n\nOut of 618 participants, 57.0% (n=352) played online games. Among gamers, 12.5% (n = 44) were classed as addicted to the gaming based on GAS scores. Compared to those not addicted to gaming, participants with gaming addiction had significantly poorer subjective sleep quality, higher sleep disturbance, lesser sleep duration, and higher daytime dysfunction. Gaming addiction was also more prevalent among males compared to females.\n\nGaming addiction among the Pakistani general population is significantly associated with poor sleep quality. This problem needs to be addressed at both individual and societal levels to avoid adverse long-term health impacts.", "doi": "10.1016/j.amsu.2022.103641", "pmid": "35734653", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2049-0801(22)00401-0"}, {"db": "pmc", "key": "PMC9206897"}], "notes": [], "created": "2022-08-19T05:52:20.807Z", "modified": "2022-08-19T05:52:20.821Z"}, {"entity": "publication", "iuid": "be40558f2b164b9fa6df518204e5e100", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be40558f2b164b9fa6df518204e5e100.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be40558f2b164b9fa6df518204e5e100"}}, "title": "Nurses' lived experiences of caring for patients with COVID-19: a phenomenological study.", "authors": [{"family": "Heydarikhayat", "given": "Nastaran", "initials": "N", "orcid": "0000-0001-9564-325X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dade1d8864584096b8ae0c4e8d3e2653.json"}}, {"family": "Ghanbarzehi", "given": "Nezar", "initials": "N"}, {"family": "Shahkaramzehi", "given": "Zarkhatoon", "initials": "Z"}, {"family": "Sabagh", "given": "Kimya", "initials": "K"}, {"family": "Rohani", "given": "Camelia", "initials": "C"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "J Res Nurs", "issn": "1744-988X", "volume": "27", "issue": "4", "pages": "313-327", "issn-l": null}, "abstract": "COVID-19 is an infectious disease caused by a novel Coronavirus which transmits from person to person throughout the world. This study aimed to explore the lived experiences of nurses' caring for patients with COVID-2019 in the context of the healthcare system of Iran.\n\nThis is a phenomenological study with 13 participant nurses (6 men and 7 women) who were caring for COVID-19 patients in one of the university hospitals in Southeast of Iran. Qualitative data were analysed by the seven steps of Colaizzi's method.\n\nParticipants reported around a five-month history of caring for COVID-19 patients. After analysis, 597 codes, 16 categories, four sub-themes, and one theme were extracted. \"Caring from self-sacrifice to avoidance\" was the main theme of the study with sub-themes of \"Anxiety Chain\", \"Manifestation of Humanitarian Caring\", \"Ethical Challenges\", and \"Challenges of Overcoming Crisis\".\n\nNurses explained their caring experiences with patients on a continuum from humanitarian caring and self-sacrifice to caring avoidance. Because of the multi-sources of psychological stress and ethical challenges together with this infection, healthcare managers should plan for holistic regular psychological support services, prevention of job inequalities, and do strategic planning for access to enough resources in the healthcare system.", "doi": "10.1177/17449871221079175", "pmid": "35837262", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1177_17449871221079175"}, {"db": "pmc", "key": "PMC9272502"}], "notes": [], "created": "2022-08-12T08:59:13.287Z", "modified": "2022-08-12T08:59:13.361Z"}, {"entity": "publication", "iuid": "993a589aaded439bbb88d6ff12b792cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/993a589aaded439bbb88d6ff12b792cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/993a589aaded439bbb88d6ff12b792cb"}}, "title": "Neutralisation sensitivity of the SARS-CoV-2 omicron (B.1.1.529) variant: a cross-sectional study.", "authors": [{"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Kim", "given": "Changil", "initials": "C"}, {"family": "Ehling", "given": "Roy A", "initials": "RA"}, {"family": "Pankow", "given": "Alec", "initials": "A"}, {"family": "Castro Dopico", "given": "Xaquin", "initials": "X"}, {"family": "Dyrdak", "given": "Robert", "initials": "R", "orcid": "0000-0001-8456-4898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98ad76a0e144478cb3ceabd05c9928b0.json"}}, {"family": "Martin", "given": "Darren P", "initials": "DP"}, {"family": "Reddy", "given": "Sai T", "initials": "ST"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Murrell", "given": "Ben", "initials": "B"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "issn-l": null, "volume": "22", "issue": "6", "pages": "813-820"}, "abstract": "The SARS-CoV-2 omicron (B.1.1.529) variant, which was first identified in November, 2021, spread rapidly in many countries, with a spike protein highly diverged from previously known variants, and raised concerns that this variant might evade neutralising antibody responses. We therefore aimed to characterise the sensitivity of the omicron variant to neutralisation.\n\nFor this cross-sectional study, we cloned the sequence encoding the omicron spike protein from a diagnostic sample to establish an omicron pseudotyped virus neutralisation assay. We quantified the neutralising antibody ID50 (the reciprocal dilution that produces 50% inhibition) against the omicron spike protein, and the fold-change in ID50 relative to the spike of wild-type SARS-CoV-2 (ie, the pandemic founder variant), for one convalescent reference plasma pool (WHO International Standard for anti-SARS-CoV-2 immunoglobulin [20/136]), three reference serum pools from vaccinated individuals, and two cohorts from Stockholm, Sweden: one comprising previously infected hospital workers (17 sampled in November, 2021, after vaccine rollout and nine in June or July, 2020, before vaccination) and one comprising serum from 40 randomly sampled blood donors donated during week 48 (Nov 29-Dec 5) of 2021. Furthermore, we assessed the neutralisation of omicron by five clinically relevant monoclonal antibodies (mAbs).\n\nNeutralising antibody responses in reference sample pools sampled shortly after infection or vaccination were substantially less potent against the omicron variant than against wild-type SARS-CoV-2 (seven-fold to 42-fold reduction in ID50 titres). Similarly, for sera obtained before vaccination in 2020 from a cohort of convalescent hospital workers, neutralisation of the omicron variant was low to undetectable (all ID50 titres <20). However, in serum samples obtained in 2021 from two cohorts in Stockholm, substantial cross-neutralisation of the omicron variant was observed. Sera from 17 hospital workers after infection and subsequent vaccination had a reduction in average potency of only five-fold relative to wild-type SARS-CoV-2 (geometric mean ID50 titre 495 vs 105), and two donors had no reduction in potency. A similar pattern was observed in randomly sampled blood donors (n=40), who had an eight-fold reduction in average potency against the omicron variant compared with wild-type SARS-CoV-2 (geometric mean ID50 titre 369 vs 45). We found that the omicron variant was resistant to neutralisation (50% inhibitory concentration [IC50] >10 \u03bcg/mL) by mAbs casirivimab (REGN-10933), imdevimab (REGN-10987), etesevimab (Ly-CoV016), and bamlanivimab (Ly-CoV555), which form part of antibody combinations used in the clinic to treat COVID-19. However, S309, the parent of sotrovimab, retained most of its activity, with only an approximately two-fold reduction in potency against the omicron variant compared with ancestral D614G SARS-CoV-2 (IC50 0\u00b71-0\u00b72 \u03bcg/mL).\n\nThese data highlight the extensive, but incomplete, evasion of neutralising antibody responses by the omicron variant, and suggest that boosting with licensed vaccines might be sufficient to raise neutralising antibody titres to protective levels.\n\nEuropean Union Horizon 2020 research and innovation programme, European and Developing Countries Clinical Trials Partnership, SciLifeLab, and the Erling-Persson Foundation.", "doi": "10.1016/S1473-3099(22)00129-3", "pmid": "35305699", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Omicron VoC": null}, "xrefs": [{"db": "pmc", "key": "PMC8930016"}, {"db": "pii", "key": "S1473-3099(22)00129-3"}], "notes": [], "created": "2022-01-21T16:18:07.075Z", "modified": "2023-06-19T14:45:01.450Z"}, {"entity": "publication", "iuid": "bfb6d404efd348beb404a6db8b205e69", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bfb6d404efd348beb404a6db8b205e69.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bfb6d404efd348beb404a6db8b205e69"}}, "title": "Modelling: Understanding pandemics and how to control them.", "authors": [{"family": "Marion", "given": "Glenn", "initials": "G"}, {"family": "Hadley", "given": "Liza", "initials": "L"}, {"family": "Isham", "given": "Valerie", "initials": "V"}, {"family": "Mollison", "given": "Denis", "initials": "D"}, {"family": "Panovska-Griffiths", "given": "Jasmina", "initials": "J"}, {"family": "Pellis", "given": "Lorenzo", "initials": "L"}, {"family": "Tomba", "given": "Gianpaolo Scalia", "initials": "GS"}, {"family": "Scarabel", "given": "Francesca", "initials": "F"}, {"family": "Swallow", "given": "Ben", "initials": "B"}, {"family": "Trapman", "given": "Pieter", "initials": "P", "orcid": "0000-0003-0569-1659", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a2df9c9216143cd8219de8687414709.json"}}, {"family": "Villela", "given": "Daniel", "initials": "D"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Epidemics", "issn": "1878-0067", "volume": "39", "pages": "100588", "issn-l": null}, "abstract": "New disease challenges, societal demands and better or novel types of data, drive innovations in the structure, formulation and analysis of epidemic models. Innovations in modelling can lead to new insights into epidemic processes and better use of available data, yielding improved disease control and stimulating collection of better data and new data types. Here we identify key challenges for the structure, formulation, analysis and use of mathematical models of pathogen transmission relevant to current and future pandemics.", "doi": "10.1016/j.epidem.2022.100588", "pmid": "35679714", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1755-4365(22)00035-4"}], "notes": [], "created": "2022-06-20T19:29:13.358Z", "modified": "2023-06-19T15:26:45.081Z"}, {"entity": "publication", "iuid": "866944d064874e18a373935bdfbc15c2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/866944d064874e18a373935bdfbc15c2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/866944d064874e18a373935bdfbc15c2"}}, "title": "Modelling preventive measures and their effect on generation times in emerging epidemics.", "authors": [{"family": "Favero", "given": "Martina", "initials": "M", "orcid": "0000-0002-7069-9721", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2db3da80e42141af9f697718f71caa5a.json"}}, {"family": "Scalia Tomba", "given": "Gianpaolo", "initials": "G", "orcid": "0000-0001-6581-8661", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dae7fb6267504aff8ca1f6a05c0b40aa.json"}}, {"family": "Britton", "given": "Tom", "initials": "T", "orcid": "0000-0002-9228-7357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3953e83bbffb428ab0a02f335979acb2.json"}}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "J R Soc Interface", "issn": "1742-5662", "volume": "19", "issue": "191", "pages": "20220128", "issn-l": null}, "abstract": "We present a stochastic epidemic model to study the effect of various preventive measures, such as uniform reduction of contacts and transmission, vaccination, isolation, screening and contact tracing, on a disease outbreak in a homogeneously mixing community. The model is based on an infectivity process, which we define through stochastic contact and infectiousness processes, so that each individual has an independent infectivity profile. In particular, we monitor variations of the reproduction number and of the distribution of generation times. We show that some interventions, i.e. uniform reduction and vaccination, affect the former while leaving the latter unchanged, whereas other interventions, i.e. isolation, screening and contact tracing, affect both quantities. We provide a theoretical analysis of the variation of these quantities, and we show that, in practice, the variation of the generation time distribution can be significant and that it can cause biases in the estimation of reproduction numbers. The framework, because of its general nature, captures the properties of many infectious diseases, but particular emphasis is on COVID-19, for which numerical results are provided.", "doi": "10.1098/rsif.2022.0128", "pmid": "35702865", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9198515"}], "notes": [], "created": "2022-06-20T18:13:38.873Z", "modified": "2022-08-17T13:01:07.267Z"}, {"entity": "publication", "iuid": "e712b712c9b54d0e93648c3e905903b6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e712b712c9b54d0e93648c3e905903b6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e712b712c9b54d0e93648c3e905903b6"}}, "title": "Impact of COVID-19 on palliative care of cancer patients: Perspectives from Pakistan.", "authors": [{"family": "Saeed", "given": "Sajeel", "initials": "S"}, {"family": "Tousif", "given": "Kashif", "initials": "K"}, {"family": "Fatir", "given": "Chaudhary Abdul", "initials": "CA"}, {"family": "Basit", "given": "Jawad", "initials": "J"}, {"family": "Lee", "given": "Ka Yiu", "initials": "KY"}, {"family": "Tahir", "given": "Muhammad Junaid", "initials": "MJ"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Ann Med Surg (Lond)", "issn": "2049-0801", "volume": "78", "pages": "103705", "issn-l": null}, "abstract": "The COVID-19 pandemic has adversely affected the survival rate and palliative care of cancer patients all over the globe. In Pakistan, there are only a few institutions and organizations which provide specialized facilities for palliative care. During the pandemic, these specialized facilities were further limited. As only less than one percent of people had access to palliative care across Pakistan in the pandemic, the situation can be improved by establishing more such departments, providing telemedicine, increasing social media campaigns, and highlighting the importance of palliative care among cancer patients.", "doi": "10.1016/j.amsu.2022.103705", "pmid": "35582458", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2049-0801(22)00465-4"}, {"db": "pmc", "key": "PMC9098974"}], "notes": [], "created": "2022-06-21T18:03:47.165Z", "modified": "2022-06-21T18:03:47.182Z"}, {"entity": "publication", "iuid": "981bd96ab70447d18b1d57b7dc047104", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/981bd96ab70447d18b1d57b7dc047104.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/981bd96ab70447d18b1d57b7dc047104"}}, "title": "Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19.", "authors": [{"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Grip", "given": "Jonathan", "initials": "J"}, {"family": "Lindel\u00f6f", "given": "Linnea", "initials": "L", "orcid": "0000-0002-3654-8874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b0581b9ebda046fdaf4b3c14b0b910a9.json"}}, {"family": "Rooijackers", "given": "Olav", "initials": "O"}, {"family": "Pigazzini", "given": "Sara", "initials": "S"}, {"family": "Niemi", "given": "Mari", "initials": "M"}, {"family": "Cordioli", "given": "Mattia", "initials": "M"}, {"family": "Nkambule", "given": "Lindo", "initials": "L"}, {"family": "Maricic", "given": "Tomislav", "initials": "T"}, {"family": "Ekdahl", "given": "Kristina Nilsson", "initials": "KN"}, {"family": "Nilsson", "given": "Bo", "initials": "B"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ee1510080704cf6a2a6972deb94123f.json"}}, {"family": "Eriksson", "given": "Oskar", "initials": "O", "orcid": "0000-0003-2418-6463", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d2b881e96504b58a64ea3fd004c5d18.json"}}], "type": "letter", "published": "2022-06-00", "journal": {"title": "Nat Immunol", "issn": "1529-2916", "issn-l": null, "volume": "23", "issue": "6", "pages": "861-864"}, "abstract": null, "doi": "10.1038/s41590-022-01227-w", "pmid": "35624204", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41590-022-01227-w"}], "notes": [], "created": "2022-06-21T17:43:29.723Z", "modified": "2022-08-19T12:34:29.000Z"}, {"entity": "publication", "iuid": "d96a9d8d55d344d19b36ea7aeb1f78f5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d96a9d8d55d344d19b36ea7aeb1f78f5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d96a9d8d55d344d19b36ea7aeb1f78f5"}}, "title": "Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study.", "authors": [{"family": "Greco", "given": "Massimiliano", "initials": "M", "orcid": "0000-0003-1003-4637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a25a0febf83948fc8d35a2e4122f321c.json"}}, {"family": "De Corte", "given": "Thomas", "initials": "T", "orcid": "0000-0001-5011-6640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5901255b86c34191815e106debb8a64c.json"}}, {"family": "Ercole", "given": "Ari", "initials": "A", "orcid": "0000-0001-8350-8093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3aaf57ce5a454b7aa5343bbc0462d85b.json"}}, {"family": "Antonelli", "given": "Massimo", "initials": "M", "orcid": "0000-0003-3007-1670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9cdf5e76c1ee43a896a77d6055ae6a10.json"}}, {"family": "Azoulay", "given": "Elie", "initials": "E", "orcid": "0000-0002-8162-1508", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be149aab02dd48498b6b008e119f9946.json"}}, {"family": "Citerio", "given": "Giuseppe", "initials": "G", "orcid": "0000-0002-5374-3161", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/629ff9a17f4647e5af326467b1252214.json"}}, {"family": "Morris", "given": "Andy Conway", "initials": "AC", "orcid": "0000-0002-3211-3216", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f541174f24a5466e96a094b94e42de72.json"}}, {"family": "De Pascale", "given": "Gennaro", "initials": "G", "orcid": "0000-0002-8255-0676", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7866bbe8ae614536bb2a80070212035d.json"}}, {"family": "Duska", "given": "Frantisek", "initials": "F", "orcid": "0000-0003-1559-4078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e34c8d87b5f491ba0e1cd8760db70b0.json"}}, {"family": "Elbers", "given": "Paul", "initials": "P", "orcid": "0000-0003-0447-6893", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dec9d09090cb428bbbbc3a90bf5b1ab1.json"}}, {"family": "Einav", "given": "Sharon", "initials": "S", "orcid": "0000-0001-8963-9633", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7741185472c46dcac6fc1cf5c6b9083.json"}}, {"family": "Forni", "given": "Lui", "initials": "L", "orcid": "0000-0002-0617-5309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33324a9a38a94578acb4522d84c2ded6.json"}}, {"family": "Galarza", "given": "Laura", "initials": "L", "orcid": "0000-0002-4658-748X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82e734919a2045e480995be7adab3fed.json"}}, {"family": "Girbes", "given": "Armand R J", "initials": "ARJ", "orcid": "0000-0002-0711-0494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/879982b05a1848e39c9d5f0fbde801ec.json"}}, {"family": "Grasselli", "given": "Giacomo", "initials": "G", "orcid": "0000-0002-1735-1400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a68eafa11dae413bb14842cfb8647144.json"}}, {"family": "Gusarov", "given": "Vitaly", "initials": "V", "orcid": "0000-0002-2900-1459", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/896c47a24ca94c99b7fa50513fc9387b.json"}}, {"family": "Jubb", "given": "Alasdair", "initials": "A", "orcid": "0000-0001-5593-866X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2d88d0265f54a06aea8ebdf39e2df86.json"}}, {"family": "Kesecioglu", "given": "Jozef", "initials": "J", "orcid": "0000-0002-3007-8445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9af039f78ddc46b29b25b2b337c8a01e.json"}}, {"family": "Lavinio", "given": "Andrea", "initials": "A", "orcid": "0000-0002-8832-918X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a358df8988744dd99f5aecaac0e4a850.json"}}, {"family": "Delgado", "given": "Maria Cruz Martin", "initials": "MCM", "orcid": "0000-0002-7468-4594", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7eef2e9011c4281b952175a824b9f4a.json"}}, {"family": "Mellinghoff", "given": "Johannes", "initials": "J", "orcid": "0000-0002-5455-8953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37ddf15c796a4c2ea172764a6c36f9d0.json"}}, {"family": "Myatra", "given": "Sheila Nainan", "initials": "SN", "orcid": "0000-0001-6761-163X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80f906419daa4f5e87a1c6f7a9b554af.json"}}, {"family": "Ostermann", "given": "Marlies", "initials": "M", "orcid": "0000-0001-9500-9080", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc42fc57504149a29d3ffef5efd9852c.json"}}, {"family": "Pellegrini", "given": "Mariangela", "initials": "M", "orcid": "0000-0001-5668-7399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/97386683452a4afd9e1da948bb9921f2.json"}}, {"family": "Povoa", "given": "Pedro", "initials": "P", "orcid": "0000-0002-7069-7304", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93f2b9dbca90480eb98555b44c69ef58.json"}}, {"family": "Schaller", "given": "Stefan J", "initials": "SJ", "orcid": "0000-0002-6683-9584", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5c134bb75e14b94bc723f59b7dd790e.json"}}, {"family": "Teboul", "given": "Jean-Louis", "initials": "JL", "orcid": "0000-0002-5748-7820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbd174ebc7444e769fc5fd03e9689c21.json"}}, {"family": "Wong", "given": "Adrian", "initials": "A", "orcid": "0000-0003-4968-7328", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/338f961fbb48481f893f697e5dfc1d67.json"}}, {"family": "De Waele", "given": "Jan J", "initials": "JJ", "orcid": "0000-0003-1017-9748", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/875fffe346d548b19bd3c0e0ff6fb267.json"}}, {"family": "Cecconi", "given": "Maurizio", "initials": "M", "orcid": "0000-0002-4376-6538", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79162e2a5da843ee9de35265eacc1d93.json"}}, {"family": "ESICM UNITE-COVID investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "volume": "48", "issue": "6", "pages": "690-705", "issn-l": "0342-4642"}, "abstract": "To accommodate the unprecedented number of critically ill patients with pneumonia caused by coronavirus disease 2019 (COVID-19) expansion of the capacity of intensive care unit (ICU) to clinical areas not previously used for critical care was necessary. We describe the global burden of COVID-19 admissions and the clinical and organizational characteristics associated with outcomes in critically ill COVID-19 patients.\n\nMulticenter, international, point prevalence study, including adult patients with SARS-CoV-2 infection confirmed by polymerase chain reaction (PCR) and a diagnosis of COVID-19 admitted to ICU between February 15th and May 15th, 2020.\n\n4994 patients from 280 ICUs in 46 countries were included. Included ICUs increased their total capacity from 4931 to 7630 beds, deploying personnel from other areas. Overall, 1986 (39.8%) patients were admitted to surge capacity beds. Invasive ventilation at admission was present in 2325 (46.5%) patients and was required during ICU stay in 85.8% of patients. 60-day mortality was 33.9% (IQR across units: 20%-50%) and ICU mortality 32.7%. Older age, invasive mechanical ventilation, and acute kidney injury (AKI) were associated with increased mortality. These associations were also confirmed specifically in mechanically ventilated patients. Admission to surge capacity beds was not associated with mortality, even after controlling for other factors.\n\nICUs responded to the increase in COVID-19 patients by increasing bed availability and staff, admitting up to 40% of patients in surge capacity beds. Although mortality in this population was high, admission to a surge capacity bed was not associated with increased mortality. Older age, invasive mechanical ventilation, and AKI were identified as the strongest predictors of mortality.", "doi": "10.1007/s00134-022-06705-1", "pmid": "35596752", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-022-06705-1"}, {"db": "pmc", "key": "PMC9123859"}], "notes": [], "created": "2022-06-21T17:59:43.200Z", "modified": "2022-06-21T17:59:44.237Z"}, {"entity": "publication", "iuid": "eadd3298440b494c933cb8991a2e96c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eadd3298440b494c933cb8991a2e96c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eadd3298440b494c933cb8991a2e96c0"}}, "title": "An early warning system for emerging SARS-CoV-2 variants.", "authors": [{"family": "Subissi", "given": "Lorenzo", "initials": "L", "orcid": "0000-0001-5147-575X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/454c226e834a4829a330df1c4b604855.json"}}, {"family": "von Gottberg", "given": "Anne", "initials": "A", "orcid": "0000-0002-0243-7455", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa3e854c50af4dbeb6b3c51c8feca226.json"}}, {"family": "Thukral", "given": "Lipi", "initials": "L"}, {"family": "Worp", "given": "Nathalie", "initials": "N"}, {"family": "Oude Munnink", "given": "Bas B", "initials": "BB", "orcid": "0000-0002-9394-1189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19923669d04a47ebb5c7c93d20ecedc3.json"}}, {"family": "Rathore", "given": "Surabhi", "initials": "S"}, {"family": "Abu-Raddad", "given": "Laith J", "initials": "LJ", "orcid": "0000-0003-0790-0506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebbd58612cec4b76aa8f00efc37adefb.json"}}, {"family": "Aguilera", "given": "Ximena", "initials": "X", "orcid": "0000-0002-8153-6733", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be3f762e99094b86b5873d7b44d24a03.json"}}, {"family": "Alm", "given": "Erik", "initials": "E"}, {"family": "Archer", "given": "Brett N", "initials": "BN", "orcid": "0000-0002-4144-1094", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3fb24f334b94306aa5d64c193980852.json"}}, {"family": "Attar Cohen", "given": "Homa", "initials": "H"}, {"family": "Barakat", "given": "Amal", "initials": "A"}, {"family": "Barclay", "given": "Wendy S", "initials": "WS", "orcid": "0000-0002-3948-0895", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a6c3e7314d645c09435f54ee0e6046d.json"}}, {"family": "Bhiman", "given": "Jinal N", "initials": "JN", "orcid": "0000-0001-6354-4003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a8c04d1addc4cbd9bc0624e709c5fb6.json"}}, {"family": "Caly", "given": "Leon", "initials": "L"}, {"family": "Chand", "given": "Meera", "initials": "M"}, {"family": "Chen", "given": "Mark", "initials": "M"}, {"family": "Cullinane", "given": "Ann", "initials": "A"}, {"family": "de Oliveira", "given": "Tulio", "initials": "T"}, {"family": "Drosten", "given": "Christian", "initials": "C", "orcid": "0000-0001-7923-0519", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5181b233d41d4c708b9dce7e74e22f6d.json"}}, {"family": "Druce", "given": "Julian", "initials": "J"}, {"family": "Effler", "given": "Paul", "initials": "P"}, {"family": "El Masry", "given": "Ihab", "initials": "I"}, {"family": "Faye", "given": "Adama", "initials": "A"}, {"family": "Gaseitsiwe", "given": "Simani", "initials": "S"}, {"family": "Ghedin", "given": "Elodie", "initials": "E", "orcid": "0000-0002-1515-725X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ffc96a3fefb4b158fbdc240b18d5149.json"}}, {"family": "Grant", "given": "Rebecca", "initials": "R"}, {"family": "Haagmans", "given": "Bart L", "initials": "BL", "orcid": "0000-0001-6221-2015", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96a8b5e7b73b4998a3c4da5af2181538.json"}}, {"family": "Herring", "given": "Belinda L", "initials": "BL"}, {"family": "Iyer", "given": "Shilpa S", "initials": "SS"}, {"family": "Kassamali", "given": "Zyleen", "initials": "Z", "orcid": "0000-0002-0668-7099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a23574374f264895b8e0ccc9141ec987.json"}}, {"family": "Kakkar", "given": "Manish", "initials": "M", "orcid": "0000-0002-3254-0496", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c3289180dbad4089ab3e557fe14174c8.json"}}, {"family": "Kondor", "given": "Rebecca J", "initials": "RJ"}, {"family": "Leite", "given": "Juliana A", "initials": "JA", "orcid": "0000-0002-8620-114X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0ef59c86dbb441594c9bb03f9083122.json"}}, {"family": "Leo", "given": "Yee-Sin", "initials": "YS", "orcid": "0000-0003-4978-5825", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ca28661a9df44a7b95577da156b54c9.json"}}, {"family": "Leung", "given": "Gabriel M", "initials": "GM"}, {"family": "Marklewitz", "given": "Marco", "initials": "M", "orcid": "0000-0003-1828-8770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08f8a32079f24efb8e4850ac02019606.json"}}, {"family": "Moyo", "given": "Sikhulile", "initials": "S", "orcid": "0000-0003-3821-4592", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24e198ad74e84883a5d79eb36c8df68c.json"}}, {"family": "Mendez-Rico", "given": "Jairo", "initials": "J"}, {"family": "Melhem", "given": "Nada M", "initials": "NM", "orcid": "0000-0002-5423-4908", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80d02c8de4a74f268f26ef9ef1079845.json"}}, {"family": "Munster", "given": "Vincent", "initials": "V", "orcid": "0000-0002-2288-3196", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1f2569e7fe5442d968b3d89c88599d1.json"}}, {"family": "Nahapetyan", "given": "Karen", "initials": "K"}, {"family": "Oh", "given": "Djin-Ye", "initials": "DY"}, {"family": "Pavlin", "given": "Boris I", "initials": "BI"}, {"family": "Peacock", "given": "Thomas P", "initials": "TP", "orcid": "0000-0001-7077-2928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/940835adb42b431a882f9af9acf166f7.json"}}, {"family": "Peiris", "given": "Malik", "initials": "M", "orcid": "0000-0001-8217-5995", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9395f3f6fc44427b0dbf04988bfde22.json"}}, {"family": "Peng", "given": "Zhibin", "initials": "Z"}, {"family": "Poon", "given": "Leo L M", "initials": "LLM", "orcid": "0000-0002-9101-7953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6595eec1d268410fad9018a8c7dd20c6.json"}}, {"family": "Rambaut", "given": "Andrew", "initials": "A", "orcid": "0000-0003-4337-3707", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d25e62e17c243f3ab72304ca504e296.json"}}, {"family": "Sacks", "given": "Jilian", "initials": "J"}, {"family": "Shen", "given": "Yinzhong", "initials": "Y"}, {"family": "Siqueira", "given": "Marilda M", "initials": "MM"}, {"family": "Tessema", "given": "Sofonias K", "initials": "SK"}, {"family": "Volz", "given": "Erik M", "initials": "EM", "orcid": "0000-0001-6268-8937", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9be67903cdcf4953b8905562984517e8.json"}}, {"family": "Thiel", "given": "Volker", "initials": "V", "orcid": "0000-0002-5783-0887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c6d7b184da743e5975d3009cad5a802.json"}}, {"family": "van der Werf", "given": "Sylvie", "initials": "S", "orcid": "0000-0002-1148-4456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/610e999fc3fa4d24aceecf5a13122ecf.json"}}, {"family": "Briand", "given": "Sylvie", "initials": "S"}, {"family": "Perkins", "given": "Mark D", "initials": "MD"}, {"family": "Van Kerkhove", "given": "Maria D", "initials": "MD", "orcid": "0000-0002-6135-0018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/217da117247b46428c2f5ea15c3f1bf9.json"}}, {"family": "Koopmans", "given": "Marion P G", "initials": "MPG", "orcid": "0000-0002-5204-2312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80d7f1e97b934289b7095013ef6e998d.json"}}, {"family": "Agrawal", "given": "Anurag", "initials": "A"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "volume": "28", "issue": "6", "pages": "1110-1115", "issn-l": "1078-8956"}, "abstract": null, "doi": "10.1038/s41591-022-01836-w", "pmid": "35637337", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-022-01836-w"}], "notes": [], "created": "2022-06-21T17:38:16.669Z", "modified": "2022-06-21T17:38:32.806Z"}, {"entity": "publication", "iuid": "c7a44b6b483f4fe0a665c19900fdacb3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7a44b6b483f4fe0a665c19900fdacb3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7a44b6b483f4fe0a665c19900fdacb3"}}, "title": "The chimera of S1 and N proteins of SARS-CoV-2: can it be a potential vaccine candidate for COVID-19?", "authors": [{"family": "Kumar", "given": "Amresh", "initials": "A"}, {"family": "Ladha", "given": "Amit", "initials": "A"}, {"family": "Choudhury", "given": "Ankita", "initials": "A"}, {"family": "Ikbal", "given": "Abu Md Ashif", "initials": "AMA"}, {"family": "Bhattacharjee", "given": "Bedanta", "initials": "B"}, {"family": "Das", "given": "Tanmay", "initials": "T"}, {"family": "Gupta", "given": "Gaurav", "initials": "G"}, {"family": "Sharma", "given": "Chhavi", "initials": "C"}, {"family": "Sarbajna", "given": "Adity", "initials": "A"}, {"family": "Mandal", "given": "Subhash C", "initials": "SC"}, {"family": "Choudhury", "given": "Manabendra Dutta", "initials": "MD"}, {"family": "Ali", "given": "Nahid", "initials": "N"}, {"family": "Slama", "given": "Petr", "initials": "P"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Palit", "given": "Partha", "initials": "P"}, {"family": "Tiwari", "given": "Onkar Nath", "initials": "ON"}], "type": "journal article", "published": "2022-05-31", "journal": {"title": "Expert Rev Vaccines", "issn": "1744-8395", "pages": "1-16", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as one of the biggest global health issues. Spike protein (S) and nucleoprotein (N), the major immunogenic components of SARS-CoV-2, have been shown to be involved in the attachment and replication of the virus inside the host cell.\n\nSeveral investigations have shown that the SARS-CoV-2 nucleoprotein can elicit a cell-mediated immune response capable of regulating viral replication and lowering viral burden. However, the development of an effective vaccine that can stop the transmission of SARS-CoV-2 remains a matter of concern. Literature was retrieved using the keywords COVID-19 vaccine, role of nucleoprotein as vaccine candidate, spike protein, nucleoprotein immune responses against SARS-CoV-2, and chimera vaccine in PubMed, Google Scholar, and Google.\n\nWe have focussed on the use of chimera protein, consisting of N and S-1 protein components of SARS-CoV-2, as a potential vaccine candidate. This may act as a polyvalent mixed recombinant protein vaccine to elicit a strong T and B cell immune response, which will be capable of neutralizing the wild and mutated variants of SARS-CoV-2, and also restricting its attachment, replication, and budding in the host cell.", "doi": "10.1080/14760584.2022.2081156", "pmid": "35604776", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T17:53:36.946Z", "modified": "2022-06-21T17:53:36.980Z"}, {"entity": "publication", "iuid": "1595cf333fbb4fde88159a514e865a3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1595cf333fbb4fde88159a514e865a3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1595cf333fbb4fde88159a514e865a3d"}}, "title": "Guidelines for Perioperative Care in Elective Abdominal and Pelvic Surgery at Primary and Secondary Hospitals in Low-Middle-Income Countries (LMIC's): Enhanced Recovery After Surgery (ERAS) Society Recommendation.", "authors": [{"family": "Oodit", "given": "Ravi", "initials": "R"}, {"family": "Biccard", "given": "Bruce M", "initials": "BM"}, {"family": "Panieri", "given": "Eugenio", "initials": "E"}, {"family": "Alvarez", "given": "Adrian O", "initials": "AO"}, {"family": "Sioson", "given": "Marianna R S", "initials": "MRS"}, {"family": "Maswime", "given": "Salome", "initials": "S"}, {"family": "Thomas", "given": "Viju", "initials": "V"}, {"family": "Kluyts", "given": "Hyla-Louise", "initials": "HL"}, {"family": "Peden", "given": "Carol J", "initials": "CJ"}, {"family": "de Boer", "given": "Hans D", "initials": "HD"}, {"family": "Brindle", "given": "Mary", "initials": "M"}, {"family": "Francis", "given": "Nader K", "initials": "NK"}, {"family": "Nelson", "given": "Gregg", "initials": "G"}, {"family": "Gustafsson", "given": "Ulf O", "initials": "UO"}, {"family": "Ljungqvist", "given": "Olle", "initials": "O"}], "type": "journal article", "published": "2022-05-31", "journal": {"title": "World J Surg", "issn": "1432-2323", "issn-l": null}, "abstract": "This is the first Enhanced Recovery After Surgery (ERAS\u00ae) Society guideline for primary and secondary hospitals in low-middle-income countries (LMIC's) for elective abdominal and gynecologic care.\n\nThe ERAS LMIC Guidelines group was established by the ERAS\u00ae Society in collaboration with different representatives of perioperative care from LMIC's. The group consisted of seven members from the ERAS\u00ae Society and eight members from LMIC's. An updated systematic literature search and evaluation of evidence from previous ERAS\u00ae guidelines was performed by the leading authors of the Colorectal (2018) and Gynecologic (2019) surgery guidelines (Gustafsson et al in World J Surg 43:6592-695, Nelson et al in Int J Gynecol Cancer 29(4):651-668). Meta-analyses randomized controlled trials (RCTs), prospective and retrospective cohort studies from both HIC's and LMIC's were considered for each perioperative item. The members in the LMIC group then applied the current evidence and adapted the recommendations for each intervention as well as identifying possible new items relevant to LMIC's. The Grading of Recommendations, Assessment, Development and Evaluation system (GRADE) methodology was used to determine the quality of the published evidence. The strength of the recommendations was based on importance of the problem, quality of evidence, balance between desirable and undesirable effects, acceptability to key stakeholders, cost of implementation and specifically the feasibility of implementing in LMIC's and determined through discussions and consensus.\n\nIn addition to previously described ERAS\u00ae Society interventions, the following items were included, revised or discussed: the Surgical Safety Checklist (SSC), preoperative routine human immunodeficiency virus (HIV) testing in countries with a high prevalence of HIV/AIDS (CD4 and viral load for those patients that are HIV positive), delirium screening and prevention, COVID 19 screening, VTE prophylaxis, immuno-nutrition, prehabilitation, minimally invasive surgery (MIS) and a standardized postoperative monitoring guideline.\n\nThese guidelines are seen as a starting point to address the urgent need to improve perioperative care and to effect data-driven, evidence-based care in LMIC's.", "doi": "10.1007/s00268-022-06587-w", "pmid": "35641574", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00268-022-06587-w"}], "notes": [], "created": "2022-06-21T17:36:07.435Z", "modified": "2022-06-21T17:36:07.451Z"}, {"entity": "publication", "iuid": "07dd3b7e73b048b29dc9036d4ed4561b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07dd3b7e73b048b29dc9036d4ed4561b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07dd3b7e73b048b29dc9036d4ed4561b"}}, "title": "Critical Care Nurses' Experiences Caring for Patients When Relatives Were not Allowed in the ICUs due to COVID-19 Pandemic.", "authors": [{"family": "Stenman", "given": "Lina", "initials": "L"}, {"family": "H\u00f6gberg", "given": "Lisa", "initials": "L"}, {"family": "Engstr\u00f6m", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0001-6244-6401", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f93844031da44a79bc89f3d73da4477f.json"}}], "type": "journal article", "published": "2022-05-31", "journal": {"title": "SAGE Open Nurs", "issn": "2377-9608", "volume": "8", "pages": "23779608221103627", "issn-l": null}, "abstract": "Health care workers faced new challenges during the COVID-19 pandemic when physical contact with relatives more or less disappeared.\n\nThe aim of this study is to describe the experiences of critical care nurses (CCNs) working in intensive care units (ICUs) under the visiting restrictions imposed as a result of COVID-19.\n\nThis study followed a qualitative design. The purposive sample included CCNs with at least 1 year of experience working in an ICU with a visiting policy affected by the pandemic. Data collection was carried out via semi-structured interviews and analyzed through a qualitative content analysis with an inductive approach.\n\nThe study results are presented in three categories with 10 subcategories. CCNs value the presence of patients' relatives at the bedside and described many challenges when relatives could not be present with the patient during the pandemic.\n\nClose relatives are able to share essential information about the patients and provide much-needed emotional support to them, the relatives' role is of central importance and CCNs value their presence in ICUs more than any positive consequences of them not being there.", "doi": "10.1177/23779608221103627", "pmid": "35669888", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1177_23779608221103627"}, {"db": "pmc", "key": "PMC9163743"}], "notes": [], "created": "2022-06-20T19:32:37.982Z", "modified": "2022-06-20T19:32:38.037Z"}, {"entity": "publication", "iuid": "d264d65d67174ddabfb94234c528049b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d264d65d67174ddabfb94234c528049b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d264d65d67174ddabfb94234c528049b"}}, "title": "An analysis of how health systems integrated priority-setting in the pandemic planning in a sample of Latin America and the Caribbean countries.", "authors": [{"family": "V\u00e9lez", "given": "Claudia-Marcela", "initials": "CM"}, {"family": "Aguilera", "given": "Bernardo", "initials": "B"}, {"family": "Kapiriri", "given": "Lydia", "initials": "L", "orcid": "0000-0002-1237-6369", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec392c3ae33d40f096e713eaa6a2be11.json"}}, {"family": "Essue", "given": "Beverley M", "initials": "BM"}, {"family": "Nouvet", "given": "Elysee", "initials": "E"}, {"family": "Sandman", "given": "Lars", "initials": "L"}, {"family": "Williams", "given": "Iestyn", "initials": "I"}], "type": "journal article", "published": "2022-05-31", "journal": {"title": "Health Res Policy Syst", "issn": "1478-4505", "volume": "20", "issue": "1", "pages": "58", "issn-l": null}, "abstract": "Latin America and the Caribbean (LAC) are among those regions most affected by the COVID-19 pandemic worldwide. The COVID-19 pandemic has strained health systems in the region. In this context of severe healthcare resource constraints, there is a need for systematic priority-setting to support decision-making which ensures the best use of resources while considering the needs of the most vulnerable groups. The aim of this paper was to provide a critical description and analysis of how health systems considered priority-setting in the COVID-19 response and preparedness plans of a sample of 14 LAC countries; and to identify the associated research gaps.\n\nA documentary analysis of COVID-19 preparedness and response plans was performed in a sample of 14 countries in the LAC region. We assessed the degree to which the documented priority-setting processes adhered to established quality indicators of effective priority-setting included in the Kapiriri and Martin framework. We conducted a descriptive analysis of the degree to which the reports addressed the quality parameters for each individual country, as well as a cross-country comparison to explore whether parameters varied according to independent variables.\n\nWhile all plans were led and supported by the national governments, most included only a limited number of quality indicators for effective priority-setting. There was no systematic pattern between the number of quality indicators and the country's health system and political contexts; however, the countries that had the least number of quality indicators tended to be economically disadvantaged.\n\nThis study adds to the literature by providing the first descriptive analysis of the inclusion of priority-setting during a pandemic, using the case of COVID-19 response and preparedness plans in the LAC region. The analysis found that despite the strong evidence of political will and stakeholder participation, none of the plans presented a clear priority-setting process, or used a formal priority-setting framework, to define interventions, populations, geographical regions, healthcare setting or resources prioritized. There is need for case studies that analyse how priority-setting actually occurred during the COVID-19 pandemic and the degree to which the implementation reflected the plans and the parameters of effective priority-setting, as well as the impact of the prioritization processes on population health, with a focus on the most vulnerable groups.", "doi": "10.1186/s12961-022-00861-y", "pmid": "35642055", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12961-022-00861-y"}], "notes": [], "created": "2022-06-21T17:35:46.517Z", "modified": "2022-06-21T17:35:46.600Z"}, {"entity": "publication", "iuid": "6cc5cac975e84955a775563b5c242bf0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6cc5cac975e84955a775563b5c242bf0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6cc5cac975e84955a775563b5c242bf0"}}, "title": "Quality of life (QoL) among COVID-19 recovered healthcare workers in Bangladesh.", "authors": [{"family": "Rashid", "given": "Md Utba", "initials": "MU"}, {"family": "Khan", "given": "Md Abdullah Saeed", "initials": "MAS"}, {"family": "Dalal", "given": "Koustuv", "initials": "K", "orcid": "0000-0001-7393-796X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab5e44a17b7545988cb46cdf5b1f3e4e.json"}}, {"family": "Sagar", "given": "Soumik Kha", "initials": "SK"}, {"family": "Hossian", "given": "Mosharop", "initials": "M"}, {"family": "Barsha", "given": "Sabrina Yesmin", "initials": "SY"}, {"family": "Haque", "given": "Miah Md Akiful", "initials": "MMA"}, {"family": "Ali Hossain", "given": "Mohammad", "initials": "M"}, {"family": "Hayatun Nabi", "given": "Mohammad", "initials": "M"}, {"family": "Hawlader", "given": "Mohammad Delwer Hossain", "initials": "MDH"}], "type": "journal article", "published": "2022-05-30", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "volume": "22", "issue": "1", "pages": "716", "issn-l": null}, "abstract": "The Coronavirus Disease 2019 (COVID-19) caused by the SARS-CoV-2 virus has taken the lives of more than 100,000 healthcare workers (HCWs) so far. Those who survived continuously work under immense physical and psychological pressure, and their quality of life (QoL) is impacted. The study aimed to assess the QoL among HCWs in Bangladesh who recovered from COVID-19.\n\nThis cross-sectional, telephonic interview-based study was conducted among 322 randomly selected HCWs from Bangladesh who were positive for COVID-19 and recovered from the infection before the interview. Data were collected from June to November 2020. We examined the impact of COVID on the QoL of the participants using the validated Bangladesh version of the World Health Organization (WHO) Quality of life questionnaire brief (WHOQOL-BREF). All analyses were done by STATA (Version 16.1).\n\nMore than half of the health care professionals were male (56.0%), aged between 26-35 years (51%), and completed graduation (49%). The majority of the study participants in the four domains were married (n = 263, 81%) and living in Dhaka. The average score of the participants was 70.91 \u00b1 13.07, 62.68 \u00b1 14.99, 66.93 \u00b1 15.14, and 63.56 \u00b1 12.11 in physical, psychological, social relationship and environmental domains, respectively. HCWs in urban areas enjoyed 2.4 times better socially stable lives (OR: 2.42, 95% CI: 1.18-4.96) but 72% less psychologically satisfactory lives.\n\nHCWs' post-COVID quality of life depended on variable interaction of demographic socioeconomic, including old age, female sex, graduation, and higher monthly income. The findings indicate the issues which should be addressed to improve the quality of life of frontline workers who fight against the pandemic.", "doi": "10.1186/s12913-022-07961-z", "pmid": "35637475", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-022-07961-z"}], "notes": [], "created": "2022-06-21T17:36:57.103Z", "modified": "2022-06-21T17:37:33.850Z"}, {"entity": "publication", "iuid": "5e658bf185dd46ceaf587101889e1b73", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e658bf185dd46ceaf587101889e1b73.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e658bf185dd46ceaf587101889e1b73"}}, "title": "Pre-exascale HPC approaches for molecular dynamics simulations. Covid-19 research: A use case.", "authors": [{"family": "Wiecz\u00f3r", "given": "Mi\u0142osz", "initials": "M"}, {"family": "Genna", "given": "Vito", "initials": "V"}, {"family": "Aranda", "given": "Juan", "initials": "J"}, {"family": "Badia", "given": "Rosa M", "initials": "RM", "orcid": "0000-0003-2941-5499", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/118643637250473c831a71d4229a94b4.json"}}, {"family": "Gelp\u00ed", "given": "Josep Llu\u00eds", "initials": "JL"}, {"family": "Gapsys", "given": "Vytautas", "initials": "V", "orcid": "0000-0002-6761-7780", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f09aac84213f4745a30d5aa4b21d39a0.json"}}, {"family": "de Groot", "given": "Bert L", "initials": "BL"}, {"family": "Lindahl", "given": "Erik", "initials": "E"}, {"family": "Municoy", "given": "Mart\u00ed", "initials": "M", "orcid": "0000-0003-4399-153X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822616e19cea40f4a71d758873555eb6.json"}}, {"family": "Hospital", "given": "Adam", "initials": "A"}, {"family": "Orozco", "given": "Modesto", "initials": "M", "orcid": "0000-0002-8608-3278", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d51c4e79f3a4b6f90868149ffbf7daa.json"}}], "type": "journal article", "published": "2022-05-30", "journal": {"title": "Wiley Interdiscip Rev Comput Mol Sci", "issn": "1759-0876", "pages": "e1622", "issn-l": null}, "abstract": "Exascale computing has been a dream for ages and is close to becoming a reality that will impact how molecular simulations are being performed, as well as the quantity and quality of the information derived for them. We review how the biomolecular simulations field is anticipating these new architectures, making emphasis on recent work from groups in the BioExcel Center of Excellence for High Performance Computing. We exemplified the power of these simulation strategies with the work done by the HPC simulation community to fight Covid-19 pandemics. This article is categorized under:Data Science > Computer Algorithms and ProgrammingData Science > Databases and Expert SystemsMolecular and Statistical Mechanics > Molecular Dynamics and Monte-Carlo Methods.", "doi": "10.1002/wcms.1622", "pmid": "35935573", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "WCMS1622"}, {"db": "pmc", "key": "PMC9347456"}], "notes": [], "created": "2022-08-11T11:53:30.133Z", "modified": "2022-08-11T11:53:48.319Z"}, {"entity": "publication", "iuid": "9af1ae25bf344ecf94993e1aa5dab071", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9af1ae25bf344ecf94993e1aa5dab071.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9af1ae25bf344ecf94993e1aa5dab071"}}, "title": "The significance of surface neutrophilic MPO expression level in NETosis and NETosis-associated coagulopathies in covid-19 infected patients.", "authors": [{"family": "Jamali", "given": "Elham", "initials": "E"}, {"family": "Abbasi", "given": "Mojdeh", "initials": "M"}, {"family": "Tayer", "given": "Akbar Hashemi", "initials": "AH"}, {"family": "Monfared", "given": "Ali Arabi", "initials": "AA"}, {"family": "Tandel", "given": "Parisa", "initials": "P"}, {"family": "Tamaddon", "given": "Gholamhossein", "initials": "G"}, {"family": "Kazerooni", "given": "Ehsan Sarraf", "initials": "ES"}, {"family": "Rakhshandehroo", "given": "Shahrokh", "initials": "S"}, {"family": "Ranjbaran", "given": "Reza", "initials": "R"}], "type": "journal article", "published": "2022-05-29", "journal": {"title": "Blood Cells Mol Dis", "issn": "1096-0961", "volume": "96", "pages": "102676", "issn-l": null}, "abstract": "Inflammatory response-induced coagulopathy is a common complication associated with severe form of covid-19 infection. Evidences suggest that neutrophil extracellular traps (NETs) play a significant role in triggering the immunothrombosis in this condition. We aimed to evaluate the diagnostic value of surface neutrophilic myeloperoxidase (MPO) as NETosis biomarker for predicting the risk of covid-19-associated coagulopathies.\n\nCovid-19 infection was assessed by real-time-PCR and plasma d-dimer levels were measured by ELFA. Based on the covid-19 infection and d-dimer level outcomes, patients were categorized into four groups. Any alteration in the serum level of IL-6, H3Cit and neutrophilic surface MPO were analyzed by CLIA, ELISA, and flow cytometry, respectively.\n\nH3Cit variations and different d-dimer values confirmed the association between NETosis and coagulopathies. Findings showed that the expression of neutrophilic MPO reduced in cases with NETosis, which was correlated with increased levels of H3Cit. ANC/MPO ratio was signified as a valuable marker to discriminate the covid-19 and non covid-19-associated coagulopathies and could be considered as a prognostic factor due to its noteworthy correlation with serum IL-6 concentration.\n\nDeclined levels of surface neutrophilic MPO in NETosis correlate with covid-19-associated coagulopathies and increased IL-6 levels, as a potential biomarker of covid-19 disease severity.", "doi": "10.1016/j.bcmd.2022.102676", "pmid": "35661911", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1079-9796(22)00033-X"}], "notes": [], "created": "2022-06-21T17:16:55.067Z", "modified": "2022-06-21T17:16:55.097Z"}, {"entity": "publication", "iuid": "a96ded4eb17e4db38a262e53b6c1976c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a96ded4eb17e4db38a262e53b6c1976c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a96ded4eb17e4db38a262e53b6c1976c"}}, "title": "Transforming or tinkering: the world remains unprepared for the next pandemic threat.", "authors": [{"family": "Clark", "given": "Helen", "initials": "H"}, {"family": "C\u00e1rdenas", "given": "Mauricio", "initials": "M"}, {"family": "Dybul", "given": "Mark", "initials": "M"}, {"family": "Kazatchkine", "given": "Michel", "initials": "M"}, {"family": "Liu", "given": "Joanne", "initials": "J"}, {"family": "Miliband", "given": "David", "initials": "D"}, {"family": "Nordstr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Sudan", "given": "Preeti", "initials": "P"}, {"family": "Zedillo", "given": "Ernesto", "initials": "E"}, {"family": "Obaid", "given": "Thoraya", "initials": "T"}, {"family": "McCarney", "given": "Rosemary", "initials": "R"}, {"family": "Radin", "given": "Elizabeth", "initials": "E"}, {"family": "Eliasz", "given": "Mike Kalmus", "initials": "MK"}, {"family": "McNab", "given": "Christine", "initials": "C"}, {"family": "Legido-Quigley", "given": "Helena", "initials": "H"}, {"family": "Sirleaf", "given": "Ellen Johnson", "initials": "EJ"}], "type": "journal article", "published": "2022-05-28", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "399", "issue": "10340", "pages": "1995-1999", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(22)00929-1", "pmid": "35597246", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(22)00929-1"}, {"db": "pmc", "key": "PMC9114832"}], "notes": [], "created": "2022-06-21T17:58:47.542Z", "modified": "2022-06-21T17:59:16.940Z"}, {"entity": "publication", "iuid": "3232d2ae3e22401c8cbac0ff88028687", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3232d2ae3e22401c8cbac0ff88028687.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3232d2ae3e22401c8cbac0ff88028687"}}, "title": "Battling extraordinary situations and conflicting emotions-A qualitative study of being a newly graduated Registered Nurse in the emergency department during the COVID-19 pandemic.", "authors": [{"family": "Carnesten", "given": "Hillewi", "initials": "H", "orcid": "0000-0002-6512-849X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6fb875140b7345fa9e94862b866e066c.json"}}, {"family": "Wiklund Gustin", "given": "Lena", "initials": "L", "orcid": "0000-0002-9714-577X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8bcbede9d577497495130e22dd6a6c88.json"}}, {"family": "Skoglund", "given": "Karin", "initials": "K", "orcid": "0000-0001-8008-8169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e6fc2925ce9443e865e3dc39411af54.json"}}, {"family": "Von Heideken W\u00e5gert", "given": "Petra", "initials": "P", "orcid": "0000-0001-6292-7010", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4d6dfb26a37419385eb8e257f89d950.json"}}], "type": "journal article", "published": "2022-05-28", "journal": {"title": "Nurs Open", "issn": "2054-1058", "issn-l": null}, "abstract": "To describe newly graduated registered nurses' (NGRNs') experiences of encountering stress in emergency departments (EDs) during the COVID-19 pandemic.\n\nA qualitative descriptive study.\n\nData from 14 in-depth interviews with NGRNs working in an ED for 3-36 months after graduation was analysed by the means of qualitative content analysis as described by Graneheim and Lundman. Interviews were conducted from March to November 2020 covering the first two waves of the pandemic.\n\nData revealed three categories and nine subcategories comprised in the theme Battling extraordinary situations and conflicting emotions. Empowered by acknowledging themselves as important caregivers during the pandemic NGRNs struggle against limitations and exert themselves beyond their known limit. External stressors due to work overload in combination with understaffing force NGRNs into the role of the experienced nurse prematurely and internal stressors derives from part taking in less qualitative care.", "doi": "10.1002/nop2.1250", "pmid": "35633153", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T17:39:20.222Z", "modified": "2022-06-21T17:39:20.361Z"}, {"entity": "publication", "iuid": "1c4f45fce1454dd9a3156ad81c103970", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1c4f45fce1454dd9a3156ad81c103970.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1c4f45fce1454dd9a3156ad81c103970"}}, "title": "Time Trend in SARS-CoV-2 Seropositivity, Surveillance Detection- and Infection Fatality Ratio until Spring 2021 in the Tirschenreuth County-Results from a Population-Based Longitudinal Study in Germany.", "authors": [{"family": "Einhauser", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-4177-4451", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0d657959e714aa18b8cda14ae8b260d.json"}}, {"family": "Peterhoff", "given": "David", "initials": "D", "orcid": "0000-0001-5911-6233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3784a38e6f81455e9af931fae1c0b830.json"}}, {"family": "Beileke", "given": "Stephanie", "initials": "S"}, {"family": "G\u00fcnther", "given": "Felix", "initials": "F", "orcid": "0000-0001-6582-1174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b533ef33e9a4769b5ba32a0e616f5c0.json"}}, {"family": "Niller", "given": "Hans-Helmut", "initials": "HH"}, {"family": "Steininger", "given": "Philipp", "initials": "P"}, {"family": "Kn\u00f6ll", "given": "Antje", "initials": "A"}, {"family": "Korn", "given": "Klaus", "initials": "K", "orcid": "0000-0003-1891-2107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a90fec0b05a4968b6ac28e9c4b675d8.json"}}, {"family": "Berr", "given": "Melanie", "initials": "M"}, {"family": "Sch\u00fctz", "given": "Anja", "initials": "A"}, {"family": "Wiegrebe", "given": "Simon", "initials": "S"}, {"family": "Stark", "given": "Klaus J", "initials": "KJ"}, {"family": "Gessner", "given": "Andr\u00e9", "initials": "A"}, {"family": "Burkhardt", "given": "Ralph", "initials": "R", "orcid": "0000-0003-1924-1202", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4eb3b61804944e6a065c85267832d8a.json"}}, {"family": "Kabesch", "given": "Michael", "initials": "M"}, {"family": "Schedl", "given": "Holger", "initials": "H"}, {"family": "K\u00fcchenhoff", "given": "Helmut", "initials": "H"}, {"family": "Pfahlberg", "given": "Annette B", "initials": "AB", "orcid": "0000-0002-2234-1215", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5c6a8a551ed4d9e9f51afe633b3080c.json"}}, {"family": "Heid", "given": "Iris M", "initials": "IM"}, {"family": "Gefeller", "given": "Olaf", "initials": "O", "orcid": "0000-0002-8985-7582", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15905044556b4978bca8b0728c901348.json"}}, {"family": "\u00dcberla", "given": "Klaus", "initials": "K", "orcid": "0000-0001-7822-3835", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/221ba6c8276a405380303915261e3558.json"}}, {"family": "Wagner", "given": "Ralf", "initials": "R"}], "type": "journal article", "published": "2022-05-27", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "6", "issn-l": "1999-4915"}, "abstract": "Herein, we provide results from a prospective population-based longitudinal follow-up (FU) SARS-CoV-2 serosurveillance study in Tirschenreuth, the county which was hit hardest in Germany in spring 2020 and early 2021. Of 4203 individuals aged 14 years or older enrolled at baseline (BL, June 2020), 3546 participated at FU1 (November 2020) and 3391 at FU2 (April 2021). Key metrics comprising standardized seroprevalence, surveillance detection ratio (SDR), infection fatality ratio (IFR) and success of the vaccination campaign were derived using the Roche N- and S-Elecsys anti-SARS-CoV-2 test together with a self-administered questionnaire. N-seropositivity at BL was 9.2% (1st wave). While we observed a low new seropositivity between BL and FU1 (0.9%), the combined 2nd and 3rd wave accounted for 6.1% new N-seropositives between FU1 and FU2 (ever seropositives at FU2: 15.4%). The SDR decreased from 5.4 (BL) to 1.1 (FU2) highlighting the success of massively increased testing in the population. The IFR based on a combination of serology and registration data resulted in 3.3% between November 2020 and April 2021 compared to 2.3% until June 2020. Although IFRs were consistently higher at FU2 compared to BL across age-groups, highest among individuals aged 70+ (18.3% versus 10.7%, respectively), observed differences were within statistical uncertainty bounds. While municipalities with senior care homes showed a higher IFR at BL (3.0% with senior care home vs. 0.7% w/o), this effect diminished at FU2 (3.4% vs. 2.9%). In April 2021 (FU2), vaccination rate in the elderly was high (&gt;77.4%, age-group 80+).", "doi": "10.3390/v14061168", "pmid": "35746640", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "v14061168"}, {"db": "pmc", "key": "PMC9228731"}], "notes": [], "created": "2022-08-19T05:42:07.176Z", "modified": "2022-08-19T05:42:28.995Z"}, {"entity": "publication", "iuid": "82358c5f8f5d41f385b21a78b1c1cc94", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82358c5f8f5d41f385b21a78b1c1cc94.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82358c5f8f5d41f385b21a78b1c1cc94"}}, "title": "Resilience and post-traumatic growth in the transition to motherhood during the COVID-19 pandemic: A qualitative exploratory study.", "authors": [{"family": "Thomson", "given": "Gill", "initials": "G", "orcid": "0000-0003-3392-8182", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01ec0dfaaa56415eb9121e6451021640.json"}}, {"family": "Cook", "given": "Julie", "initials": "J"}, {"family": "Nowland", "given": "Rebecca", "initials": "R"}, {"family": "Donnellan", "given": "Warren James", "initials": "WJ", "orcid": "0000-0002-0224-9155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32764a489b614baeb20ac6ae07593a85.json"}}, {"family": "Topalidou", "given": "Anastasia", "initials": "A"}, {"family": "Jackson", "given": "Leanne", "initials": "L"}, {"family": "Fallon", "given": "Vicky", "initials": "V"}], "type": "journal article", "published": "2022-05-27", "journal": {"title": "Scand J Caring Sci", "issn": "1471-6712", "issn-l": null}, "abstract": "Most perinatal research relating to COVID-19 focuses on its negative impact on maternal and parental mental health. Currently, there are limited data on how to optimise positive health during the pandemic. We aimed to bridge this knowledge gap by exploring how women have adapted to becoming a new parent during the pandemic and to identify elements of resilience and growth within their narratives. Mothers of infants under the age of 4 months were recruited as part of a wider UK mixed-methods study. Semi-structured interviews with 20 mothers elicited data about how COVID-19 had influenced their transition to parent a new infant, and if and how they adapted during the pandemic, what strategies they used, and if and how these had been effective. Directed qualitative content analysis was undertaken, and pre-existing theoretical frameworks of resilience and post-traumatic growth (PTG) were used to analyse and interpret the data set. The findings show evidence of a range of resilience and PTG concepts experienced during the pandemic in this cohort. Salient resilience themes included personal (active coping, reflective functioning, and meaning-making), relational (social support, partner relationships, and family relationships), and contextual (health and social connectedness) factors. There was also evidence of PTG in terms of the potential for new work-related and leisure opportunities, and women developing wider and more meaningful connections with others. Although further research is needed, and with individuals from diverse socioeconomic backgrounds, these findings emphasise the significance of social support and connectivity as vital to positive mental health. Opportunities to increase digital innovations to connect and support new parents should be maximised to buffer the negative impacts of further social distancing and crisis situations.", "doi": "10.1111/scs.13087", "pmid": "35621069", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2022-06-21T17:45:42.061Z", "modified": "2022-06-21T17:46:19.515Z"}, {"entity": "publication", "iuid": "08da99ee2ab34869aa7cc6201fbf2cda", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/08da99ee2ab34869aa7cc6201fbf2cda.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/08da99ee2ab34869aa7cc6201fbf2cda"}}, "title": "Determination of IgG1 and IgG3 SARS-CoV-2 Spike Protein and Nucleocapsid Binding-Who Is Binding Who and Why?", "authors": [{"family": "Iles", "given": "Jason K", "initials": "JK"}, {"family": "Zmuidinaite", "given": "Raminta", "initials": "R", "orcid": "0000-0001-7728-6623", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/421ae7d6575445888ac6bb7f537b4b16.json"}}, {"family": "Sadee", "given": "Christoph", "initials": "C"}, {"family": "Gardiner", "given": "Anna", "initials": "A"}, {"family": "Lacey", "given": "Jonathan", "initials": "J"}, {"family": "Harding", "given": "Stephen", "initials": "S"}, {"family": "Wallis", "given": "Gregg", "initials": "G"}, {"family": "Patel", "given": "Roshani", "initials": "R"}, {"family": "Roblett", "given": "Debra", "initials": "D"}, {"family": "Heeney", "given": "Jonathan", "initials": "J"}, {"family": "Baxendale", "given": "Helen", "initials": "H"}, {"family": "Iles", "given": "Ray Kruse", "initials": "RK"}], "type": "journal article", "published": "2022-05-27", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "23", "issue": "11", "pages": "6050", "issn-l": null}, "abstract": "The involvement of immunoglobulin (Ig) G3 in the humoral immune response to SARS-CoV-2 infection has been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS) in COVID-19. The exact molecular mechanism is unknown, but it is thought to involve this IgG subtype's differential ability to fix, complement and stimulate cytokine release. We examined the binding of convalescent patient antibodies to immobilized nucleocapsids and spike proteins by matrix-assisted laser desorption/ionization-time of flight (MALDI-ToF) mass spectrometry. IgG3 was a major immunoglobulin found in all samples. Differential analysis of the spectral signatures found for the nucleocapsid versus the spike protein demonstrated that the predominant humoral immune response to the nucleocapsid was IgG3, whilst for the spike protein it was IgG1. However, the spike protein displayed a strong affinity for IgG3 itself, as it would bind from control plasma samples, as well as from those previously infected with SARS-CoV-2, similar to the way protein G binds IgG1. Furthermore, detailed spectral analysis indicated that a mass shift consistent with hyper-glycosylation or glycation was a characteristic of the IgG3 captured by the spike protein.", "doi": "10.3390/ijms23116050", "pmid": "35682724", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9181569"}, {"db": "pii", "key": "ijms23116050"}], "notes": [], "created": "2022-06-20T19:26:26.231Z", "modified": "2023-06-19T14:54:05.767Z"}, {"entity": "publication", "iuid": "3aa502c25f0c4b22b6f27b6881488e53", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3aa502c25f0c4b22b6f27b6881488e53.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3aa502c25f0c4b22b6f27b6881488e53"}}, "title": "Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity.", "authors": [{"family": "Batlle", "given": "Daniel", "initials": "D"}, {"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Garreta", "given": "Elena", "initials": "E"}, {"family": "Hassler", "given": "Luise", "initials": "L"}, {"family": "Wysocki", "given": "Jan", "initials": "J"}, {"family": "Chandar", "given": "Vasuretha", "initials": "V"}, {"family": "Schwartz", "given": "Robert E", "initials": "RE"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Montserrat", "given": "Nuria", "initials": "N"}, {"family": "Bader", "given": "Michael", "initials": "M"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}], "type": "letter", "published": "2022-05-26", "journal": {"title": "Cell", "issn": "1097-4172", "volume": "185", "issue": "11", "pages": "1837-1839", "issn-l": "0092-8674"}, "abstract": null, "doi": "10.1016/j.cell.2022.05.004", "pmid": "35623327", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0092-8674(22)00588-8"}], "notes": [], "created": "2022-06-21T17:44:41.930Z", "modified": "2022-06-21T17:44:41.944Z"}, {"entity": "publication", "iuid": "0e400cb9bc494d649666d89f4e9b636b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e400cb9bc494d649666d89f4e9b636b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e400cb9bc494d649666d89f4e9b636b"}}, "title": "Editorial: Platelet Function in COVID-19.", "authors": [{"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A"}, {"family": "Sand\u00e9n", "given": "Per", "initials": "P"}, {"family": "Mitroulis", "given": "Ioannis", "initials": "I"}, {"family": "van der Meijden", "given": "Paola E J", "initials": "PEJ"}], "type": "editorial", "published": "2022-05-26", "journal": {"title": "Front Cardiovasc Med", "issn": "2297-055X", "volume": "9", "pages": "912472", "issn-l": null}, "abstract": null, "doi": "10.3389/fcvm.2022.912472", "pmid": "35722094", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC9204630"}], "notes": [], "created": "2022-08-17T12:46:16.941Z", "modified": "2022-08-17T12:46:16.954Z"}, {"entity": "publication", "iuid": "7243b81f939c47b88b5e8e0ce022db0a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7243b81f939c47b88b5e8e0ce022db0a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7243b81f939c47b88b5e8e0ce022db0a"}}, "title": "Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction.", "authors": [{"family": "Guimond", "given": "Scott E", "initials": "SE"}, {"family": "Mycroft-West", "given": "Courtney J", "initials": "CJ"}, {"family": "Gandhi", "given": "Neha S", "initials": "NS", "orcid": "0000-0003-3119-6731", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78db66b38cb24a759aaed5fd1a7246e6.json"}}, {"family": "Tree", "given": "Julia A", "initials": "JA"}, {"family": "Le", "given": "Thuy T", "initials": "TT"}, {"family": "Spalluto", "given": "C Mirella", "initials": "CM"}, {"family": "Humbert", "given": "Maria V", "initials": "MV"}, {"family": "Buttigieg", "given": "Karen R", "initials": "KR"}, {"family": "Coombes", "given": "Naomi", "initials": "N"}, {"family": "Elmore", "given": "Michael J", "initials": "MJ"}, {"family": "Wand", "given": "Matthew", "initials": "M"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Said", "given": "Joanna", "initials": "J"}, {"family": "Setoh", "given": "Yin Xiang", "initials": "YX"}, {"family": "Amarilla", "given": "Alberto A", "initials": "AA"}, {"family": "Modhiran", "given": "Naphak", "initials": "N"}, {"family": "Sng", "given": "Julian D J", "initials": "JDJ"}, {"family": "Chhabra", "given": "Mohit", "initials": "M"}, {"family": "Young", "given": "Paul R", "initials": "PR"}, {"family": "Rawle", "given": "Daniel J", "initials": "DJ"}, {"family": "Lima", "given": "Marcelo A", "initials": "MA"}, {"family": "Yates", "given": "Edwin A", "initials": "EA", "orcid": "0000-0001-9365-5433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/16a88f385653436bb561e77ffc4fd73a.json"}}, {"family": "Karlsson", "given": "Richard", "initials": "R"}, {"family": "Miller", "given": "Rebecca L", "initials": "RL", "orcid": "0000-0001-8574-1948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8aae63723f184b4791e0b61f55d023fc.json"}}, {"family": "Chen", "given": "Yen-Hsi", "initials": "YH"}, {"family": "Bagdonaite", "given": "Ieva", "initials": "I", "orcid": "0000-0002-9383-8448", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5981026aabfd475787f9a79a2ea7340f.json"}}, {"family": "Yang", "given": "Zhang", "initials": "Z"}, {"family": "Stewart", "given": "James", "initials": "J"}, {"family": "Nguyen", "given": "Dung", "initials": "D"}, {"family": "Laidlaw", "given": "Stephen", "initials": "S"}, {"family": "Hammond", "given": "Edward", "initials": "E"}, {"family": "Dredge", "given": "Keith", "initials": "K"}, {"family": "Wilkinson", "given": "Tom M A", "initials": "TMA"}, {"family": "Watterson", "given": "Daniel", "initials": "D"}, {"family": "Khromykh", "given": "Alexander A", "initials": "AA"}, {"family": "Suhrbier", "given": "Andreas", "initials": "A"}, {"family": "Carroll", "given": "Miles W", "initials": "MW"}, {"family": "Trybala", "given": "Edward", "initials": "E"}, {"family": "Bergstr\u00f6m", "given": "Tomas", "initials": "T"}, {"family": "Ferro", "given": "Vito", "initials": "V", "orcid": "0000-0003-3306-2550", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/059cdf96e0114bb4ab46289d10956055.json"}}, {"family": "Skidmore", "given": "Mark A", "initials": "MA"}, {"family": "Turnbull", "given": "Jeremy E", "initials": "JE", "orcid": "0000-0002-1791-754X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/066f42660595487e817530f8888ee45a.json"}}], "type": "journal article", "published": "2022-05-25", "journal": {"title": "ACS Cent Sci", "issn": "2374-7943", "volume": "8", "issue": "5", "pages": "527-545", "issn-l": null}, "abstract": "Heparan sulfate (HS) is a cell surface polysaccharide recently identified as a coreceptor with the ACE2 protein for the S1 spike protein on SARS-CoV-2 virus, providing a tractable new therapeutic target. Clinically used heparins demonstrate an inhibitory activity but have an anticoagulant activity and are supply-limited, necessitating alternative solutions. Here, we show that synthetic HS mimetic pixatimod (PG545), a cancer drug candidate, binds and destabilizes the SARS-CoV-2 spike protein receptor binding domain and directly inhibits its binding to ACE2, consistent with molecular modeling identification of multiple molecular contacts and overlapping pixatimod and ACE2 binding sites. Assays with multiple clinical isolates of SARS-CoV-2 virus show that pixatimod potently inhibits the infection of monkey Vero E6 cells and physiologically relevant human bronchial epithelial cells at safe therapeutic concentrations. Pixatimod also retained broad potency against variants of concern (VOC) including B.1.1.7 (Alpha), B.1.351 (Beta), B.1.617.2 (Delta), and B.1.1.529 (Omicron). Furthermore, in a K18-hACE2 mouse model, pixatimod significantly reduced SARS-CoV-2 viral titers in the upper respiratory tract and virus-induced weight loss. This demonstration of potent anti-SARS-CoV-2 activity tolerant to emerging mutations establishes proof-of-concept for targeting the HS-Spike protein-ACE2 axis with synthetic HS mimetics and provides a strong rationale for clinical investigation of pixatimod as a potential multimodal therapeutic for COVID-19.", "doi": "10.1021/acscentsci.1c01293", "pmid": "35647275", "labels": {"Category: Biochemistry": null, "Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9136977"}], "notes": [], "created": "2022-06-21T17:31:54.664Z", "modified": "2023-06-19T14:56:08.925Z"}, {"entity": "publication", "iuid": "456dc8ed53b644328aedc39158d52624", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/456dc8ed53b644328aedc39158d52624.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/456dc8ed53b644328aedc39158d52624"}}, "title": "Prior-aware autoencoders for lung pathology segmentation.", "authors": [{"family": "Astaraki", "given": "Mehdi", "initials": "M"}, {"family": "Smedby", "given": "\u00d6rjan", "initials": "\u00d6"}, {"family": "Wang", "given": "Chunliang", "initials": "C"}], "type": "journal article", "published": "2022-05-25", "journal": {"title": "Med Image Anal", "issn": "1361-8423", "volume": "80", "pages": "102491", "issn-l": null}, "abstract": "Segmentation of lung pathology in Computed Tomography (CT) images is of great importance for lung disease screening. However, the presence of different types of lung pathologies with a wide range of heterogeneities in size, shape, location, and texture, on one side, and their visual similarity with respect to surrounding tissues, on the other side, make it challenging to perform reliable automatic lesion segmentation. To leverage segmentation performance, we propose a deep learning framework comprising a Normal Appearance Autoencoder (NAA) model to learn the distribution of healthy lung regions and reconstruct pathology-free images from the corresponding pathological inputs by replacing the pathological regions with the characteristics of healthy tissues. Detected regions that represent prior information regarding the shape and location of pathologies are then integrated into a segmentation network to guide the attention of the model into more meaningful delineations. The proposed pipeline was tested on three types of lung pathologies, including pulmonary nodules, Non-Small Cell Lung Cancer (NSCLC), and Covid-19 lesion on five comprehensive datasets. The results show the superiority of the proposed prior model, which outperformed the baseline segmentation models in all the cases with significant margins. On average, adding the prior model improved the Dice coefficient for the segmentation of lung nodules by 0.038, NSCLCs by 0.101, and Covid-19 lesions by 0.041. We conclude that the proposed NAA model produces reliable prior knowledge regarding the lung pathologies, and integrating such knowledge into a prior segmentation network leads to more accurate delineations.", "doi": "10.1016/j.media.2022.102491", "pmid": "35653902", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1361-8415(22)00138-4"}], "notes": [], "created": "2022-06-21T17:21:31.741Z", "modified": "2022-06-21T17:21:46.880Z"}, {"entity": "publication", "iuid": "754359aeb3274887b4ed42654c5cb5a7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/754359aeb3274887b4ed42654c5cb5a7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/754359aeb3274887b4ed42654c5cb5a7"}}, "title": "COVID-19 seroprevalence and clinical picture in Swedish pediatric oncology and hematology patients.", "authors": [{"family": "Sundberg", "given": "Emil", "initials": "E", "orcid": "0000-0001-5087-1400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62ac6304201e4ec181ea55bcadd16b0d.json"}}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Nilsson", "given": "Anna", "initials": "A", "orcid": "0000-0001-5885-7101", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e552225ab82346d1b2d727584683f156.json"}}, {"family": "Pahnke", "given": "Simon", "initials": "S"}, {"family": "Enblad", "given": "Gunilla", "initials": "G"}, {"family": "Kolstad", "given": "Linda", "initials": "L"}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Torkki", "given": "Milla", "initials": "M"}, {"family": "Zhou", "given": "Otto", "initials": "O"}, {"family": "Anderson", "given": "Jenna", "initials": "J"}, {"family": "Harila-Saari", "given": "Arja", "initials": "A", "orcid": "0000-0003-2767-5828", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61332c8f7db64f4e81a61f3b68439025.json"}}, {"family": "Palle", "given": "Josefine", "initials": "J"}], "type": "journal article", "published": "2022-05-25", "journal": {"title": "Pediatr Blood Cancer", "issn": "1545-5017", "pages": "e29773", "issn-l": null}, "abstract": "Children develop symptomatic coronavirus disease 2019 (COVID-19) more rarely than adults upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pediatric oncology and hematology patients may be at increased risk of severe COVID-19 due to their underlying disease or treatment. We investigated COVID-19 and seroprevalence of anti-SARS-CoV-2 antibodies, respectively, in a Swedish cohort of pediatric oncology and hematology patients.\n\nPatients (n = 136) were recruited between June 2020 and September 2021 at Uppsala University Children's Hospital, Sweden. Up to six consecutive blood samples per patient were analyzed for wild-type anti-S1 IgM and IgG antibodies (including after vaccination, n = 4). Clinical data on COVID-19 (including polymerase chain reaction [PCR] test results) were collected from electronic medical records. A questionnaire was completed at recruitment.\n\nA cumulative seroprevalence (IgM and IgG) of 33% (45/136 patients, 95% confidence interval: 25%-41%) was observed in this patient cohort, of whom 66% (90/136 patients) were under severe immunosuppressive treatment during the study period. Increasing patient age (p = .037) and PCR test results (p < .002) were associated with seropositivity in nonvaccinated cases. Most seropositive, nonvaccinated cases (32/43, 74%) were never PCR-verified for SARS-CoV-2 infection. Of the 13 patients with PCR-verified infection, nine (69%) reported mild disease. A majority (63%) reported continued school attendance during the pandemic.\n\nSwedish pediatric oncology and hematology patients developed antibodies against SARS-CoV-2, despite their diagnosis and/or treatment, and the observed seroprevalence was similar to that in national pediatric outpatients. PCR-verified cases underestimate the true incidence of COVID-19 in this patient cohort.", "doi": "10.1002/pbc.29773", "pmid": "35615775", "labels": {"Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Research Area: Pandemic preparedness": null, "Type: Journal article": null, "Category: Health": null, "Research Area: Drug discovery and repurposing of drugs": null}, "xrefs": [], "notes": [], "created": "2022-06-21T17:48:12.392Z", "modified": "2022-06-21T17:49:07.415Z"}, {"entity": "publication", "iuid": "737f9cdb4b82484db6b5c7f3e581bb86", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/737f9cdb4b82484db6b5c7f3e581bb86.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/737f9cdb4b82484db6b5c7f3e581bb86"}}, "title": "Assessing Access to WASH in Urban Schools during COVID-19 in Kazakhstan: Case Study of Central Kazakhstan.", "authors": [{"family": "Toleubekov", "given": "Berik", "initials": "B", "orcid": "0000-0003-2156-5513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de10dab596684ac6b713795af6a862d6.json"}}, {"family": "Bolatova", "given": "Zhanerke", "initials": "Z"}, {"family": "Stafstr\u00f6m", "given": "Martin", "initials": "M", "orcid": "0000-0002-6392-3588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/875e62bf093942a990203d3e4dd20d70.json"}}], "type": "journal article", "published": "2022-05-25", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "11", "issn-l": null}, "abstract": "The WHO/UNICEF Joint Monitoring Program (JMP) for Water Supply, Sanitation and Hygiene (WASH) produces global estimates of the real situation of access to water, sanitation and hygiene services, and sanitation and hygiene in households, educational institutes and health care facilities; however it is lacking data on schools in Kazakhstan. Thus, the aim of this research was to assess access to WASH in schools of urban area in Kazakhstan. The study was conducted in seven schools of Central Kazakhstan during the COVID-19 pandemic and restrictive measures. Three data collection methods were used: a questionnaire for administrative staff, a questionnaire for parents and observation. Parents of offline study pupils (only second and third grades due to the pandemic) were included in the survey. Students had access to in-building toilets in all schools connected to the centralized sewer. The number of school toilets varied from 7 (KAZ200085) to 61 (KAZ200089). The average amount of toilets was 28.08 \u00b1 16.97. Only two out of seven schools complied with the requirements of Kazakhstan national sanitary standards for the ratio of school toilets to the number of students. From the questionnaire with the school administrations, it was defined that the primary source of drinking water was the public water supply. All schools regularly disinfect and check the water supply system. At the same time, the results also revealed discrepancies in the answers between administration and parents (2.6% of parents showed that their children have rare access to drinking water), and insufficient monitoring of implementation of WASH services. This study also confirmed that the full provision of access to water and water services in the structure of educational institutions solves several SDG targets.", "doi": "10.3390/ijerph19116438", "pmid": "35682022", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19116438"}], "notes": [], "created": "2022-06-20T19:27:40.112Z", "modified": "2022-06-20T19:27:40.249Z"}, {"entity": "publication", "iuid": "cdf1dc4e16d74a99bdbc48ee13abcea5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cdf1dc4e16d74a99bdbc48ee13abcea5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cdf1dc4e16d74a99bdbc48ee13abcea5"}}, "title": "Amyloidogenesis of SARS-CoV-2 Spike Protein.", "authors": [{"family": "Nystr\u00f6m", "given": "Sofie", "initials": "S", "orcid": "0000-0002-4303-4783", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7996ddca29dc4632a0a37327ad0388b4.json"}}, {"family": "Hammarstr\u00f6m", "given": "Per", "initials": "P", "orcid": "0000-0001-5827-3587", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b57ea4fc5c2842628fe34bb8cda78889.json"}}], "type": "journal article", "published": "2022-05-25", "journal": {"title": "J Am Chem Soc", "issn": "1520-5126", "volume": "144", "issue": "20", "pages": "8945-8950", "issn-l": null}, "abstract": "SARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances together with neurologic and cardiac problems led us to investigate the amyloidogenicity of the SARS-CoV-2 spike protein (S-protein). Amyloid fibril assays of peptide library mixtures and theoretical predictions identified seven amyloidogenic sequences within the S-protein. All seven peptides in isolation formed aggregates during incubation at 37 \u00b0C. Three 20-amino acid long synthetic spike peptides (sequence 192-211, 601-620, 1166-1185) fulfilled three amyloid fibril criteria: nucleation dependent polymerization kinetics by ThT, Congo red positivity, and ultrastructural fibrillar morphology. Full-length folded S-protein did not form amyloid fibrils, but amyloid-like fibrils with evident branching were formed during 24 h of S-protein coincubation with the protease neutrophil elastase (NE) in vitro. NE efficiently cleaved S-protein, rendering exposure of amyloidogenic segments and accumulation of the amyloidogenic peptide 194-203, part of the most amyloidogenic synthetic spike peptide. NE is overexpressed at inflamed sites of viral infection. Our data propose a molecular mechanism for potential amyloidogenesis of SARS-CoV-2 S-protein in humans facilitated by endoproteolysis. The prospective of S-protein amyloidogenesis in COVID-19 disease associated pathogenesis can be important in understanding the disease and long COVID-19.", "doi": "10.1021/jacs.2c03925", "pmid": "35579205", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T18:04:57.349Z", "modified": "2022-06-21T18:04:57.462Z"}, {"entity": "publication", "iuid": "76e6763d7f8044789c7df8692fde2bd3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76e6763d7f8044789c7df8692fde2bd3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76e6763d7f8044789c7df8692fde2bd3"}}, "title": "Venerable vulnerability or remarkable resilience? A prospective study of the impact of the first wave of the COVID-19 pandemic and quarantine measures on loneliness in Swedish older adults with home care.", "authors": [{"family": "Gustafsson", "given": "Per E", "initials": "PE", "orcid": "0000-0002-3972-5362", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9ac282ae534432f9e8135a8070683bc.json"}}, {"family": "Nilsson", "given": "Ingeborg", "initials": "I"}, {"family": "San Sebastian", "given": "Miguel", "initials": "M"}], "type": "journal article", "published": "2022-05-24", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "5", "pages": "e060209", "issn-l": "2044-6055"}, "abstract": "To examine the early impact of the pandemic and of quarantine measures targeting older adults introduced in March 2020 on loneliness among older adults in Sweden.Design Prospective pretest-posttest and controlled interrupted time series designs.\n\nThe population of older adults receiving home care before and during the emergence of the first COVID-19 pandemic wave in Sweden in Spring 2020.\n\nRespondents (n=45 123, mean age 85.6 years, 67.6% women) came from two waves of a total population survey targeting all community-dwelling older adults receiving home care for older adults in Sweden in Spring 2019 and 2020.\n\nSelf-reported loneliness.\n\nResults estimated 14% (95% CI: 10 to 19) higher loneliness in Spring 2020 compared with 2019, taking covariates into account. No impact of the quarantine measure was found (1% increase, 95% CI: -1 to 4).\n\nThe results illustrate the broader public health consequences of the COVID-19 pandemic for older adults, but also suggest a relative resilience among older adults in home care to quarantine measures, at least during the first months of the pandemic. Future studies should examine the long-term effects of sustained pandemic and social distancing measures on loneliness among older adults.", "doi": "10.1136/bmjopen-2021-060209", "pmid": "35613816", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-060209"}], "notes": [], "created": "2022-06-21T17:50:27.186Z", "modified": "2022-06-21T17:50:27.216Z"}, {"entity": "publication", "iuid": "0c4f666e5c354548a2cfcebd30d440c3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c4f666e5c354548a2cfcebd30d440c3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c4f666e5c354548a2cfcebd30d440c3"}}, "title": "Antimicrobial use in Sweden during the COVID-19 pandemic: prescription fill and inpatient care requisition patterns.", "authors": [{"family": "Nakitanda", "given": "Aya Olivia", "initials": "AO"}, {"family": "Karlsson", "given": "P\u00e4r", "initials": "P"}, {"family": "L\u00f6fling", "given": "Lukas", "initials": "L"}, {"family": "Cesta", "given": "Carolyn E", "initials": "CE"}, {"family": "Odsbu", "given": "Ingvild", "initials": "I"}], "type": "journal article", "published": "2022-05-24", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "volume": "22", "issue": "1", "pages": "492", "issn-l": null}, "abstract": "Increased and inappropriate antimicrobial use are the key drivers of the emergence of antimicrobial resistance, and there have been widespread concerns around potential antimicrobial misuse, overuse and their consequences during the COVID-19 pandemic. To better understand the impact of the pandemic on antimicrobial use, particularly in light of the resurgence of COVID-19 cases since the summer of 2020, we assessed trends in antimicrobial prescription fills and hospital requisitions in Sweden during 2020 against those of preceding years.\n\nWe performed a descriptive study using population-based data from the Swedish Prescribed Drug Register and the Swedish e-Health Agency. The weekly number of prescriptions filled and the total volume sold to inpatient care institutions in defined daily doses (DDDs) per 1000 inhabitants for systemic antibacterials (Anatomical Therapeutic Chemical therapeutic subgroup J01 excluding J01XX), antimycotics (J02), antivirals (J05) and antiprotozoals (P01) were computed and evaluated from time series graphs. A time series linear regression with ordinary least squares (OLS) estimation was used to model 2015-2019 data and predict the expected number of prescriptions filled and volumes sold in DDDs per 1000 inhabitants during 2020 with 95% confidence limits.\n\nFrom mid-March 2020, the weekly rate of antibiotic and antiprotozoal prescriptions filled plummeted to unprecedentedly low levels for the rest of the year; while unprecedentedly high numbers of antiviral prescriptions were filled weekly between mid-February and mid-March 2020. There was a net reduction in annual dispensing of antibiotics by 17%; of antiprotozoals by 21%; and of antivirals by 0.3% during 2020 compared to 2019. Inpatient care requisitions of antiprotozoals and antibiotics surged to 6-year highs during March 2020, resulting in a 127% increase in DDDs of antiprotozoals sold from 2019. The volume of antibiotics and antivirals sold to inpatient care institutions in 2020 decreased by 3% and 13% compared to 2019, respectively.\n\nThe overall decline in antimicrobial prescriptions filled in Sweden during 2020 were in part, collateral dividends of the COVID-19 pandemic.", "doi": "10.1186/s12879-022-07405-3", "pmid": "35610597", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC9128331"}, {"db": "pii", "key": "10.1186/s12879-022-07405-3"}], "notes": [], "created": "2023-01-13T13:37:43.906Z", "modified": "2023-01-13T13:37:43.909Z"}, {"entity": "publication", "iuid": "385d9bb6a0ce4897a3dc84dce0af7a1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/385d9bb6a0ce4897a3dc84dce0af7a1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/385d9bb6a0ce4897a3dc84dce0af7a1d"}}, "title": "Editorial: The Consequences of COVID-19 on the Mental Well-Being of Parents, Children and Adolescents.", "authors": [{"family": "Sorbring", "given": "Emma", "initials": "E"}, {"family": "Svensson", "given": "Ylva", "initials": "Y"}, {"family": "Erlandsson", "given": "Soly I", "initials": "SI"}, {"family": "Deater-Deckard", "given": "Kirby", "initials": "K"}], "type": "editorial", "published": "2022-05-23", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "13", "pages": "924599", "issn-l": "1664-0640"}, "abstract": null, "doi": "10.3389/fpsyt.2022.924599", "pmid": "35677874", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC9168802"}], "notes": [], "created": "2022-06-20T19:30:16.042Z", "modified": "2022-06-20T19:30:30.212Z"}, {"entity": "publication", "iuid": "3284070f61ac48e3a02443b00a603a24", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3284070f61ac48e3a02443b00a603a24.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3284070f61ac48e3a02443b00a603a24"}}, "title": "The spoils of war and the long-term spoiling of health conditions of entire nations.", "authors": [{"family": "Navarese", "given": "Eliano P", "initials": "EP"}, {"family": "Grzelakowska", "given": "Klaudyna", "initials": "K"}, {"family": "Mangini", "given": "Francesco", "initials": "F"}, {"family": "Kubica", "given": "Jacek", "initials": "J"}, {"family": "Banach", "given": "Maciej", "initials": "M"}, {"family": "Benn", "given": "Marianne", "initials": "M"}, {"family": "Binder", "given": "Christoph J", "initials": "CJ"}, {"family": "Bor\u00e9n", "given": "Jan", "initials": "J"}, {"family": "Catapano", "given": "Alberico", "initials": "A"}, {"family": "Kronenberg", "given": "Florian", "initials": "F"}, {"family": "Mallat", "given": "Ziad", "initials": "Z"}, {"family": "Moulin", "given": "Philippe", "initials": "P"}, {"family": "\u00d6\u00f6rni", "given": "Katariina", "initials": "K"}, {"family": "Ray", "given": "Kausik K", "initials": "KK"}, {"family": "Roeters van Lennep", "given": "Jeanine E", "initials": "JE"}, {"family": "Romeo", "given": "Stefano", "initials": "S"}, {"family": "Tokgozoglu", "given": "Lale", "initials": "L"}, {"family": "von Eckardstein", "given": "Arnold", "initials": "A"}, {"family": "Zambon", "given": "Alberto", "initials": "A"}, {"family": "Raggi", "given": "Paolo", "initials": "P"}], "type": "editorial", "published": "2022-05-21", "journal": {"title": "Atherosclerosis", "issn": "1879-1484", "issn-l": null}, "abstract": "The healthcare system of Ukraine was already suffering from several shortfalls before February 2022, but the war of aggression started by the Russian leadership is poised to inflict a further severe blow that will have long-lasting consequences for the health of all Ukrainians. In pre-war Ukraine, noncommunicable diseases (NCDs) contributed to 91% of deaths, especially cardiovascular diseases (67%). Ukrainians have a high prevalence of risk factors for NCDs ranking among the highest levels reported by the World Health Organization (WHO) in the European (EU) Region. Cardiovascular disease is one of the key health risks for the conflict-affected Ukrainian population due to significant limitations in access to health care and interruptions in the supply of medicines and resources. The excess mortality observed during the COVID-19 pandemic, due to a combination of viral illness and chronic disease states, is bound to increase exponentially from poorly treated NCDs. In this report, we discuss the impact of the war on the public health of Ukraine and potential interventions to provide remote health assistance to the Ukrainian population.", "doi": "10.1016/j.atherosclerosis.2022.05.012", "pmid": "35644760", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0021-9150(22)00248-9"}], "notes": [], "created": "2022-06-21T17:34:06.754Z", "modified": "2022-06-21T17:34:06.790Z"}, {"entity": "publication", "iuid": "53dae477917e4ae38cd3d373c721a178", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53dae477917e4ae38cd3d373c721a178.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53dae477917e4ae38cd3d373c721a178"}}, "title": "Working With Refugees' Health During COVID-19-The Experience of Health- and Social Care Workers in Sweden.", "authors": [{"family": "Mangrio", "given": "Elisabeth", "initials": "E"}, {"family": "Zdravkovic", "given": "Slobodan", "initials": "S"}, {"family": "Strange", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2022-05-19", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "10", "pages": "811974", "issn-l": "2296-2565"}, "abstract": "In Sweden, often seen as one of the most egalitarian countries, the COVID-19 pandemic exposed high levels of health inequality, especially harming people with a refugee background. This is also despite Sweden's image as a refugee-friendly country. In this context, the aim of this paper is to better understand how Swedish health- and social workers have reacted to the health- and social needs of refugees during the pandemic. The Swedish case is particularly interesting because, as seen in the paper, health- and social workers had the task of communicating health guidance to refugees who were sometimes more reliant on information from abroad where the consensus on COVID-19 restrictions ran contrary to the approach recommended by the Swedish public health authority.\n\nThe study utilizes a qualitative content analysis of 13 in-depth interviews with health- and social workers in Sweden, active in the care of refugees within different kinds of health- and social care settings.\n\nThe analysis showed that healthcare services have remained open during the pandemic but with new precautions at reception areas impacting how refugees access healthcare. As discussed in the article, the shift to digital tools has particularly impacted refugees, worsening already existing barriers to healthcare services faced by those with refugee status. Public health recommendations were poorly designed to the needs of refugees whose living conditions often prevented them from self-isolation and social distancing. Furthermore, Sweden's initially non-restrictive approach to the pandemic instructed health- and social-workers to encourage refugees to take far fewer precautions (e.g., self-isolation, home-schooling, pregnant women to avoid virus hotspots) compared both with European neighbors and the international media typically used by refugees. When Sweden shifted toward a more restrictive approach, health- and social-workers had to revise their guidance in relation to the new recommendations around precautions.\n\nRefugees have faced increased barriers to maintaining their health and wellbeing during the pandemic that exceed those experienced by the rest of the Swedish population. Refugees have, in general, taken precautions in regard to social distancing and followed recommendations but faced challenges with social distancing due to isolation and crowded living. Public health authorities have often failed to acknowledge that individuals use increasingly diverse sources of knowledge when trying to protect their health, and that not everyone has access to the knowledge needed to access healthcare and social systems. At the same time, there is a need to acknowledge that refugees are sometimes a source of expertise that was ignored by the Swedish health and social system during the pandemic. There is a need for urgent efforts to halt the worsening health conditions for this specific group, but also to counter knock-on societal effects and rising health inequity.", "doi": "10.3389/fpubh.2022.811974", "pmid": "35669746", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9163396"}], "notes": [], "created": "2022-06-20T19:32:55.131Z", "modified": "2022-06-20T19:33:05.876Z"}, {"entity": "publication", "iuid": "dd82b322ce1f4cccb12ac2f9ebdccd6c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dd82b322ce1f4cccb12ac2f9ebdccd6c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dd82b322ce1f4cccb12ac2f9ebdccd6c"}}, "title": "The association between maternal characteristics and SARS-CoV-2 in pregnancy: a population-based registry study in Sweden and Norway.", "authors": [{"family": "\u00d6rtqvist", "given": "Anne K", "initials": "AK"}, {"family": "Magnus", "given": "Maria C", "initials": "MC"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Oakley", "given": "Laura", "initials": "L"}, {"family": "Nybo Andersen", "given": "Anne-Marie", "initials": "AM"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}], "type": "journal article", "published": "2022-05-19", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "8355", "issn-l": "2045-2322"}, "abstract": "The objectives of the current study were to identify risk factors for SARS-CoV-2 positivity, and to address how different testing strategies, choice of comparison group, and population background characteristics may influence observed associations. National registries data for 107,627 pregnant women in Sweden and 81,195 in Norway, were used to identify risk factors for SARS-CoV-2, separately for women under non-universal testing (testing by indication) and universal testing (testing of all pregnant women in contact with a delivery ward). We also investigated underlying characteristics associated with testing for SARS-CoV-2. Overall, 2.1% of pregnant women in Sweden and 1.1% in Norway were test-positive during the pandemic's first 18 months. We show that the choice of test strategy for SARS-CoV-2 provided different associations with risk factors for the disease; for instance, women who were overweight, obese or had gestational diabetes had increased odds of being test-positive under non-universal testing, but not under universal testing. Nevertheless, a consistent pattern of association between being born in the Middle East and Africa and test-positivity was found independent of test strategy and in both countries. These women were also less likely to get tested. Our results are useful to consider for surveillance and clinical recommendations for pregnant women during the current and future pandemics.", "doi": "10.1038/s41598-022-12395-y", "pmid": "35589871", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-12395-y"}, {"db": "pmc", "key": "PMC9120467"}], "notes": [], "created": "2022-06-21T18:00:33.000Z", "modified": "2022-06-21T18:00:44.440Z"}, {"entity": "publication", "iuid": "abc068b1ea5d4b08bad47d5041ef7217", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abc068b1ea5d4b08bad47d5041ef7217.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abc068b1ea5d4b08bad47d5041ef7217"}}, "title": "SARS-CoV-2 airway reactivity in children: more of the same?", "authors": [{"family": "Karlsson", "given": "J", "initials": "J", "orcid": "0000-0003-2277-0092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a428771f0dc41948d1d1e13131497bc.json"}}, {"family": "Johansen", "given": "M", "initials": "M"}, {"family": "Engelhardt", "given": "T", "initials": "T"}], "type": "editorial", "published": "2022-05-19", "journal": {"title": "Anaesthesia", "issn": "1365-2044", "issn-l": "0003-2409"}, "abstract": null, "doi": "10.1111/anae.15760", "pmid": "35587812", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T18:01:57.625Z", "modified": "2022-06-21T18:01:57.680Z"}, {"entity": "publication", "iuid": "298d8af4f737432192eebe7e304e2165", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/298d8af4f737432192eebe7e304e2165.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/298d8af4f737432192eebe7e304e2165"}}, "title": "Pandemic responses at the subnational level: Exploring politics, administration, and politicization in Swedish municipalities.", "authors": [{"family": "Sparf", "given": "J\u00f6rgen", "initials": "J", "orcid": "0000-0002-0202-0609", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01828d7aea6742b1a425f44c5c0665cf.json"}}, {"family": "Petridou", "given": "Evangelia", "initials": "E", "orcid": "0000-0001-7316-4899", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21de455914874bdf8fbaf544e51053b0.json"}}, {"family": "Granberg", "given": "Mikael", "initials": "M", "orcid": "0000-0002-5356-4112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee3d0f0c22c749b8ac5ac2f2e09dc4b4.json"}}, {"family": "Becker", "given": "Per", "initials": "P", "orcid": "0000-0001-9379-9461", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b55e9fcbd1c44de2b8c10a5bad30888b.json"}}, {"family": "Onn", "given": "Beatrice", "initials": "B"}], "type": "journal article", "published": "2022-05-19", "journal": {"title": "Eur Policy Anal", "issn": "2380-6567", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The Swedish response to the pandemic at the national level has attracted considerable international attention, but little focus has been placed on the way municipalities dealt with the crisis. Using Hay's dimensions of politicization, namely the capacity for human agency, deliberation in the public domain, and social context, we analyze the politicization of the municipal response to the pandemic in Sweden. We do this based on the analysis of the decision making process to activate (or not) an extraordinary crisis management committee. We find inter alia, that (i) only a quarter of the municipalities activated the committee while a majority of them had an alternate special organization in place; (ii) support to the existing organizational structure was more salient than creating an extraordinary organization, and (iii) a robust municipal structure was deemed to be one able to withstand shocks without resorting to extraordinary governance arrangements. We find a 'conditioned politicization' of the response, privileging administration over politics.", "doi": "10.1002/epa2.1151", "pmid": "35942065", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "EPA21151"}, {"db": "pmc", "key": "PMC9347882"}], "notes": [], "created": "2022-08-11T11:50:43.127Z", "modified": "2022-11-09T08:42:43.355Z"}, {"entity": "publication", "iuid": "2e39de17d4d34be682f9d98fa9e2c57b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e39de17d4d34be682f9d98fa9e2c57b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e39de17d4d34be682f9d98fa9e2c57b"}}, "title": "Pandemic impact on patients with advanced non-COVID-19 illness and their family carers receiving specialised palliative home care: a qualitative study.", "authors": [{"family": "Nyblom", "given": "Stina", "initials": "S", "orcid": "0000-0002-4998-0324", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9037f37fbb29422dab6a2a59a8d74a85.json"}}, {"family": "Benkel", "given": "Inger", "initials": "I"}, {"family": "Carling", "given": "Linn\u00e9a", "initials": "L"}, {"family": "L\u00f6fdahl", "given": "Elisabet", "initials": "E"}, {"family": "Molander", "given": "Ulla", "initials": "U"}, {"family": "\u00d6hl\u00e9n", "given": "Joakim", "initials": "J"}], "type": "journal article", "published": "2022-05-19", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "5", "pages": "e059577", "issn-l": "2044-6055"}, "abstract": "To investigate the experiential impact of the COVID-19 pandemic on patients with non-COVID, life-threatening disease and their family carers.\n\nAn interpretative qualitative design informed by phenomenological hermeneutics and based on data from in-depth interviews, performed between June and September 2020.\n\nPatients receiving specialised palliative home care and their family carers living in Sweden.\n\n22 patients (male/female 11/11) and 17 carers (male/female 5/12) aged 50 years and older. All the patients received specialised palliative home care and most were diagnosed with cancer.\n\naged 18 years or older, diagnosed with an incurable life-threatening, non-COVID disease, sufficient strength to participate and capacity to provide informed consent. Participants were selected through a combination of convenient and consecutive sampling.\n\nThe significance of the pandemic for both patients and carers showed a continuum from being minimally affected in comparison to the severe underlying disease to living in isolation with constant fear of becoming infected and falling ill with COVID-19, which some likened to torture.The imposed restrictions on social contact due to the pandemic were particularly palpable for this group of people with a non-COVID-19, life-limiting condition, as it was said to steal valuable moments of time that had already been measured.Most patients and carers found access to specialised palliative home care was maintained despite the pandemic. This care was of paramount importance for their sense of security and was often their sole visiting social contact.\n\nIn the pandemic situation, highly accessible support from healthcare and social care at home is particularly important to create security for both patients and carers. Thus, to provide appropriate support, it is important for healthcare and social care personnel to be aware of the great diversity of reactions patients in palliative care and their carers may have to a pandemic threat.", "doi": "10.1136/bmjopen-2021-059577", "pmid": "35589359", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-059577"}, {"db": "pmc", "key": "PMC9121113"}], "notes": [], "created": "2022-06-21T18:00:58.929Z", "modified": "2022-06-21T18:00:58.991Z"}, {"entity": "publication", "iuid": "6b86554ba821470f8ff9bbc8e29a8a0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b86554ba821470f8ff9bbc8e29a8a0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b86554ba821470f8ff9bbc8e29a8a0e"}}, "title": "Optimal Drug Regimen and Combined Drug Therapy and Its Efficacy in the Treatment of COVID-19: A Within-Host Modeling Study.", "authors": [{"family": "Chhetri", "given": "Bishal", "initials": "B"}, {"family": "Bhagat", "given": "Vijay M", "initials": "VM"}, {"family": "Vamsi", "given": "D K K", "initials": "DKK", "orcid": "0000-0002-1296-0135", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea3460b1791047619e40a7b1af74e040.json"}}, {"family": "Ananth", "given": "V S", "initials": "VS"}, {"family": "Prakash", "given": "Bhanu", "initials": "B"}, {"family": "Muthusamy", "given": "Swapna", "initials": "S"}, {"family": "Deshmukh", "given": "Pradeep", "initials": "P"}, {"family": "Sanjeevi", "given": "Carani B", "initials": "CB"}], "type": "journal article", "published": "2022-05-19", "journal": {"title": "Acta Biotheor", "issn": "1572-8358", "volume": "70", "issue": "2", "pages": "16", "issn-l": null}, "abstract": "The COVID-19 pandemic has resulted in more than 524 million cases and 6 million deaths worldwide. Various drug interventions targeting multiple stages of COVID-19 pathogenesis can significantly reduce infection-related mortality. The current within-host mathematical modeling study addresses the optimal drug regimen and efficacy of combination therapies in the treatment of COVID-19. The drugs/interventions considered include Arbidol, Remdesivir, Interferon (INF) and Lopinavir/Ritonavir. It is concluded that these drugs, when administered singly or in combination, reduce the number of infected cells and viral load. Four scenarios dealing with the administration of a single drug, two drugs, three drugs and all four are discussed. In all these scenarios, the optimal drug regimen is proposed based on two methods. In the first method, these medical interventions are modeled as control interventions and a corresponding objective function and optimal control problem are formulated. In this framework, the optimal drug regimen is derived. Later, using the comparative effectiveness method, the optimal drug regimen is derived based on the basic reproduction number and viral load. The average number of infected cells and viral load decreased the most when all four drugs were used together. On the other hand, the average number of susceptible cells decreased the most when Arbidol was administered alone. The basic reproduction number and viral load decreased the most when all four interventions were used together, confirming the previously obtained finding of the optimal control problem. The results of this study can help physicians make decisions about the treatment of the life-threatening COVID-19 infection.", "doi": "10.1007/s10441-022-09440-8", "pmid": "35588019", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10441-022-09440-8"}, {"db": "pmc", "key": "PMC9118007"}], "notes": [], "created": "2022-06-21T18:01:41.810Z", "modified": "2022-06-21T18:01:43.241Z"}, {"entity": "publication", "iuid": "bb58767a28484d2fbd148fb1a9341e6d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb58767a28484d2fbd148fb1a9341e6d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb58767a28484d2fbd148fb1a9341e6d"}}, "title": "TTCOV19: timing of tracheotomy in SARS-CoV-2-infected patients: a multicentre, single-blinded, randomized, controlled trial.", "authors": [{"family": "Eeg-Olofsson", "given": "M\u00e5ns", "initials": "M"}, {"family": "Pauli", "given": "Nina", "initials": "N"}, {"family": "Hafsten", "given": "Louise", "initials": "L"}, {"family": "Jacobsson", "given": "Josephine", "initials": "J"}, {"family": "Lundborg", "given": "Christopher", "initials": "C"}, {"family": "Brink", "given": "Magnus", "initials": "M"}, {"family": "Larsson", "given": "Helen", "initials": "H"}, {"family": "Lindell", "given": "Ellen", "initials": "E"}, {"family": "L\u00f6whagen", "given": "Karin", "initials": "K"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Bergquist", "given": "Henrik", "initials": "H"}], "type": "journal article", "published": "2022-05-18", "journal": {"title": "Crit Care", "issn": "1466-609X", "volume": "26", "issue": "1", "pages": "142", "issn-l": "1364-8535"}, "abstract": "Critically ill COVID-19 patients may develop acute respiratory distress syndrome and the need for respiratory support, including mechanical ventilation in the intensive care unit. Previous observational studies have suggested early tracheotomy to be advantageous. The aim of this parallel, multicentre, single-blinded, randomized controlled trial was to evaluate the optimal timing of tracheotomy.\n\nSARS-CoV-2-infected patients within the Region V\u00e4stra G\u00f6taland of Sweden who needed intubation and mechanical respiratory support were included and randomly assigned to early tracheotomy (\u2264 7 days after intubation) or late tracheotomy (\u2265 10 days after intubation). The primary objective was to compare the total number of mechanical ventilation days between the groups.\n\nOne hundred fifty patients (mean age 65 years, 79% males) were included. Seventy-two patients were assigned to early tracheotomy, and 78 were assigned to late tracheotomy. One hundred two patients (68%) underwent tracheotomy of whom sixty-one underwent tracheotomy according to the protocol. The overall median number of days in mechanical ventilation was 18 (IQR 9; 28), but no significant difference was found between the two treatment regimens in the intention-to-treat analysis (between-group difference: - 1.5 days (95% CI - 5.7 to 2.8); p = 0.5). A significantly reduced number of mechanical ventilation days was found in the early tracheotomy group during the per-protocol analysis (between-group difference: - 8.0 days (95% CI - 13.8 to - 2.27); p = 0.0064). The overall correlation between the timing of tracheotomy and days of mechanical ventilation was significant (Spearman's correlation: 0.39, p < 0.0001). The total death rate during intensive care was 32.7%, but no significant differences were found between the groups regarding survival, complications or adverse events.\n\nThe potential superiority of early tracheotomy when compared to late tracheotomy in critically ill patients with COVID-19 was not confirmed by the present randomized controlled trial but is a strategy that should be considered in selected cases where the need for MV for more than 14 days cannot be ruled out. Trial registration NCT04412356 , registered 05/24/2020.", "doi": "10.1186/s13054-022-04005-0", "pmid": "35585614", "labels": {"Category: Biochemistry": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-022-04005-0"}, {"db": "pmc", "key": "PMC9115544"}, {"db": "ClinicalTrials.gov", "key": "NCT04412356"}], "notes": [], "created": "2022-06-21T18:02:19.433Z", "modified": "2022-06-21T18:02:19.446Z"}, {"entity": "publication", "iuid": "bf86788503da4c2a9f9fbc540cb775a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf86788503da4c2a9f9fbc540cb775a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf86788503da4c2a9f9fbc540cb775a0"}}, "title": "Impacts of COVID-19 on people and sea: marine social science imaginations.", "authors": [{"family": "Knutsson", "given": "Per", "initials": "P"}, {"family": "Bavinck", "given": "Maarten", "initials": "M"}], "type": "journal article", "published": "2022-05-18", "journal": {"title": "Marit Stud", "issn": "2212-9790", "issn-l": null, "volume": "21", "issue": "2", "pages": "155-158"}, "abstract": null, "doi": "10.1007/s40152-022-00270-5", "pmid": "35601845", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "270"}, {"db": "pmc", "key": "PMC9114292"}], "notes": [], "created": "2022-06-21T17:56:05.333Z", "modified": "2022-11-22T05:37:52.688Z"}, {"entity": "publication", "iuid": "1b2b7251165d4c37a0d4ec7f404f552a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b2b7251165d4c37a0d4ec7f404f552a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b2b7251165d4c37a0d4ec7f404f552a"}}, "title": "Explaining the complex impact of the Covid-19 pandemic on children with overweight and obesity: a comparative ecological analysis of parents' perceptions in three countries.", "authors": [{"family": "Nowicka", "given": "P", "initials": "P"}, {"family": "Ek", "given": "A", "initials": "A"}, {"family": "Jurca-Simina", "given": "I E", "initials": "IE"}, {"family": "Bouzas", "given": "C", "initials": "C"}, {"family": "Argelich", "given": "E", "initials": "E"}, {"family": "Nordin", "given": "K", "initials": "K"}, {"family": "Garc\u00eda", "given": "S", "initials": "S"}, {"family": "Vasquez Barquero", "given": "M Y", "initials": "MY"}, {"family": "Hoffer", "given": "U", "initials": "U"}, {"family": "Reijs Richards", "given": "H", "initials": "H"}, {"family": "Tur", "given": "J A", "initials": "JA"}, {"family": "Chirita-Emandi", "given": "A", "initials": "A"}, {"family": "Eli", "given": "K", "initials": "K"}], "type": "journal article", "published": "2022-05-17", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "1000", "issn-l": null}, "abstract": "The Covid-19 pandemic has changed children's eating and physical activity behaviours. These changes have been positive for some households and negative for others, revealing health inequalities that have ramifications for childhood obesity. This study investigates the pandemic's impact on families of children aged 2-6 years with overweight or obesity.\n\nDrawing on interviews conducted as part of a randomised controlled trial (RCT) for childhood obesity, thematic analysis was used to examine how parents of pre-schoolers perceived changes in their eating, screentime and physical activity behaviours between the first and second waves of Covid-19. Parents (n = 70, representing 68 families) were interviewed twice during a period of 6 months in three countries with markedly different pandemic policies - Sweden, Romania, and Spain. The analysis is informed by Bronfenbrenner's ecological systems theory, which embeds home- and school-based influences within societal and policy contexts.\n\nThe findings show that, although all participants were recruited from an RCT for families of children with excess weight, they reported different responses to the pandemic's second wave, with some children engaging in healthier eating and physical activity, and others engaging in comfort eating and a more sedentary lifestyle. Differences in children's obesity-related behaviours were closely related to differences in parents' practices, which were, in turn, linked to their emotional and social wellbeing. Notably, across all sites, parents' feeding and physical activity facilitation practices, as well as their emotional and social wellbeing, were embedded in household resilience. In resilient households, where parents had secure housing and employment, they were better able to adapt to the challenges posed by the pandemic, whereas parents who experienced household insecurity found it more difficult to cope.\n\nAs the Covid-19 pandemic is turning into a long-term public health challenge, studies that address household resilience are crucial for developing effective prevention and treatment responses to childhood obesity.", "doi": "10.1186/s12889-022-13351-1", "pmid": "35581642", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-022-13351-1"}, {"db": "pmc", "key": "PMC9113066"}], "notes": [], "created": "2022-06-21T18:04:35.017Z", "modified": "2022-06-21T18:04:35.030Z"}, {"entity": "publication", "iuid": "8db5b4dcddc6416aafb66df37925e9b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8db5b4dcddc6416aafb66df37925e9b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8db5b4dcddc6416aafb66df37925e9b1"}}, "title": "Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm.", "authors": [{"family": "Yang", "given": "Huan", "initials": "H", "orcid": "0000-0001-8796-5523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c22b8c5acc94b878afde7fc4e39c378.json"}}, {"family": "George", "given": "Sam J", "initials": "SJ"}, {"family": "Thompson", "given": "Dane A", "initials": "DA"}, {"family": "Silverman", "given": "Harold A", "initials": "HA"}, {"family": "Tsaava", "given": "T\u00e9a", "initials": "T"}, {"family": "Tynan", "given": "Aisling", "initials": "A"}, {"family": "Pavlov", "given": "Valentin A", "initials": "VA"}, {"family": "Chang", "given": "Eric H", "initials": "EH"}, {"family": "Andersson", "given": "Ulf", "initials": "U"}, {"family": "Brines", "given": "Michael", "initials": "M"}, {"family": "Chavan", "given": "Sangeeta S", "initials": "SS"}, {"family": "Tracey", "given": "Kevin J", "initials": "KJ"}], "type": "journal article", "published": "2022-05-16", "journal": {"title": "Mol Med", "issn": "1528-3658", "volume": "28", "issue": "1", "pages": "57", "issn-l": "1076-1551"}, "abstract": "Severe COVID-19 is characterized by pro-inflammatory cytokine release syndrome (cytokine storm) which causes high morbidity and mortality. Recent observational and clinical studies suggest famotidine, a histamine 2 receptor (H2R) antagonist widely used to treat gastroesophageal reflux disease, attenuates the clinical course of COVID-19. Because evidence is lacking for a direct antiviral activity of famotidine, a proposed mechanism of action is blocking the effects of histamine released by mast cells. Here we hypothesized that famotidine activates the inflammatory reflex, a brain-integrated vagus nerve mechanism which inhibits inflammation via alpha 7 nicotinic acetylcholine receptor (\u03b17nAChR) signal transduction, to prevent cytokine storm.\n\nThe potential anti-inflammatory effects of famotidine and other H2R antagonists were assessed in mice exposed to lipopolysaccharide (LPS)-induced cytokine storm. As the inflammatory reflex is integrated and can be stimulated in the brain, and H2R antagonists penetrate the blood brain barrier poorly, famotidine was administered by intracerebroventricular (ICV) or intraperitoneal (IP) routes.\n\nFamotidine administered IP significantly reduced serum and splenic LPS-stimulated tumor necrosis factor (TNF) and IL-6 concentrations, significantly improving survival. The effects of ICV famotidine were significantly more potent as compared to the peripheral route. Mice lacking mast cells by genetic deletion also responded to famotidine, indicating the anti-inflammatory effects are not mast cell-dependent. Either bilateral sub-diaphragmatic vagotomy or genetic knock-out of \u03b17nAChR abolished the anti-inflammatory effects of famotidine, indicating the inflammatory reflex as famotidine's mechanism of action. While the structurally similar H2R antagonist tiotidine displayed equivalent anti-inflammatory activity, the H2R antagonists cimetidine or ranitidine were ineffective even at very high dosages.\n\nThese observations reveal a previously unidentified vagus nerve-dependent anti-inflammatory effect of famotidine in the setting of cytokine storm which is not replicated by high dosages of other H2R antagonists in clinical use. Because famotidine is more potent when administered intrathecally, these findings are also consistent with a primarily central nervous system mechanism of action.", "doi": "10.1186/s10020-022-00483-8", "pmid": "35578169", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s10020-022-00483-8"}, {"db": "pmc", "key": "PMC9109205"}], "notes": [], "created": "2022-06-21T18:05:26.861Z", "modified": "2022-06-21T18:05:26.918Z"}, {"entity": "publication", "iuid": "290bd3e7e98540d4a01daf46ec50d260", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/290bd3e7e98540d4a01daf46ec50d260.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/290bd3e7e98540d4a01daf46ec50d260"}}, "title": "Expecting parents' perceptions of the digital parental support \"childbirth journey\" constructed as a serious game-an intervention study.", "authors": [{"family": "B\u00e4ckstr\u00f6m", "given": "Caroline", "initials": "C", "orcid": "0000-0003-3347-482X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/362a5834f28143df864284ea02c275d8.json"}}, {"family": "Rolfson", "given": "Tanja", "initials": "T"}, {"family": "Engstr\u00f6m", "given": "Henrik", "initials": "H"}, {"family": "Knez", "given": "Rajna", "initials": "R"}, {"family": "Larsson", "given": "Margaretha", "initials": "M"}], "type": "journal article", "published": "2022-05-16", "journal": {"title": "Digit Health", "issn": "2055-2076", "volume": "8", "pages": "20552076221097776", "issn-l": null}, "abstract": "The aim of this study was to explore expecting parents' perceptions of the Childbirth Journey as an intervention that includes medical information for parental support, constructed as a serious game.\n\nIn this qualitative study, semi-structured interviews were held with expecting parents in Sweden who were able to talk about specific parts of the Childbirth Journey they appreciated or found difficult to understand. A phenomenographic methodology was employed for data analysis.\n\nParticipants perceived the Childbirth Journey to be easily accessible and customized with reliable information. The design and features of the intervention were perceived by the expecting parents to enhance the intervention's usability, appeal, and trustworthiness. When parental couples used the Childbirth Journey together, it gave them an opportunity to discuss and better understand each other's situation. The participants proposed several changes to the existing version of the game, mostly related to extending practical information and illustrated scenarios but also to the further development of the game's design and animations. The participants found the Knowledge portal to be the most appealing part of the Childbirth Journey.\n\nThe Childbirth Journey intervention was concluded to be a valuable digital complement to in-person professional support, especially given the current COVID-19 pandemic restrictions in place in Sweden, which do not allow antenatal visits by partners. However, in its current form, the Childbirth Journey has some deficiencies and would therefore benefit from further development and exploration.", "doi": "10.1177/20552076221097776", "pmid": "35603330", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1177_20552076221097776"}, {"db": "pmc", "key": "PMC9118415"}], "notes": [], "created": "2022-06-21T17:54:46.934Z", "modified": "2022-06-21T17:54:47.025Z"}, {"entity": "publication", "iuid": "3602a2b29b9e424cb4e96bbc15b426bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3602a2b29b9e424cb4e96bbc15b426bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3602a2b29b9e424cb4e96bbc15b426bf"}}, "title": "Complex Mutation Pattern of Omicron BA.2: Evading Antibodies without Losing Receptor Interactions.", "authors": [{"family": "Kannan", "given": "Saathvik R", "initials": "SR"}, {"family": "Spratt", "given": "Austin N", "initials": "AN"}, {"family": "Sharma", "given": "Kalicharan", "initials": "K", "orcid": "0000-0003-0333-2521", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/866b6de8eb3d4073a864e907c70a2c4d.json"}}, {"family": "Goyal", "given": "Ramesh", "initials": "R"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Apparsundaram", "given": "Subbu", "initials": "S"}, {"family": "Lorson", "given": "Christian L", "initials": "CL", "orcid": "0000-0002-1023-2169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58e32f41dbfe4d8a9c1debb7243baa61.json"}}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN", "orcid": "0000-0002-6889-4640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4cbe48df5ac74ffcb8a16b4f6775be1f.json"}}, {"family": "Singh", "given": "Kamal", "initials": "K", "orcid": "0000-0001-6153-8929", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b751253db0945c2b78dc4361b522a19.json"}}], "type": "journal article", "published": "2022-05-16", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "23", "issue": "10", "issn-l": null}, "abstract": "BA.2, a sublineage of Omicron BA.1, is now prominent in many parts of the world. Early reports have indicated that BA.2 is more infectious than BA.1. To gain insight into BA.2 mutation profile and the resulting impact of mutations on interactions with receptor and/or monoclonal antibodies, we analyzed available sequences, structures of Spike/receptor and Spike/antibody complexes, and conducted molecular dynamics simulations. The results showed that BA.2 had 50 high-prevalent mutations, compared to 48 in BA.1. Additionally, 17 BA.1 mutations were not present in BA.2. Instead, BA.2 had 19 unique mutations and a signature Delta variant mutation (G142D). The BA.2 had 28 signature mutations in Spike, compared to 30 in BA.1. This was due to two revertant mutations, S446G and S496G, in the receptor-binding domain (RBD), making BA.2 somewhat similar to Wuhan-Hu-1 (WT), which had G446 and G496. The molecular dynamics simulations showed that the RBD consisting of G446/G496 was more stable than S446/S496 containing RBD. Thus, our analyses suggested that BA.2 evolved with novel mutations (i) to maintain receptor binding similar to WT, (ii) evade the antibody binding greater than BA.1, and (iii) acquire mutation of the Delta variant that may be associated with the high infectivity.", "doi": "10.3390/ijms23105534", "pmid": "35628343", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Category: Omicron VoC": null}, "xrefs": [{"db": "pii", "key": "ijms23105534"}], "notes": [], "created": "2022-06-21T17:40:33.765Z", "modified": "2022-06-21T17:40:43.645Z"}, {"entity": "publication", "iuid": "673d03ccbe7d4a669271abf771c68df8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/673d03ccbe7d4a669271abf771c68df8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/673d03ccbe7d4a669271abf771c68df8"}}, "title": "Intention to get COVID-19 vaccination and its associated predictors: A cross-sectional study among the general public in Algeria.", "authors": [{"family": "Lounis", "given": "Mohamed", "initials": "M"}, {"family": "Abdelhadi", "given": "Samir", "initials": "S"}, {"family": "Rais", "given": "Mohammed Amir", "initials": "MA"}, {"family": "Bencherit", "given": "Djihad", "initials": "D"}, {"family": "Sallam", "given": "Malik", "initials": "M"}], "type": "journal article", "published": "2022-05-13", "journal": {"title": "Vacunas", "issn": "1576-9887", "issn-l": null}, "abstract": "Hesitancy towards COVID-19 vaccination and its rejection remains a major public health concern worldwide, especially in the Middle East and North African countries. The current study aimed to assess the intentions to get COVID-19 vaccines and its determinants among the general public in Algeria.\n\nA self-administered online survey was distributed during August-September 2021 using a convenience-based sampling approach. Data were collected anonymously and analyzed using IBM SPSS v22.0 software.\n\nThe study sample comprised a total of 656 participants, with 51.1% being in favor of COVID-19 vaccines while 18.5% and 30.5% were against or hesitant respectively. Only 38.6% among the study participants got vaccinated. Factors associated with higher odds of acceptance were: male sex, healthcare profession, the belief in natural origin of the pandemic and previous COVID-19 infection in family. The most common cited reasons for COVID-19 vaccine acceptance were the belief that vaccination is the only way to fight COVID-19 and the fear of getting infected by the virus; while the most common reasons of rejection were lack of trust in proper vaccine testing and fear of side effects.\n\nThe overall level of COVID-19 vaccine acceptance in this study was below the levels required to achieve population immunity. Besides certain socio-demographic characteristics, the determinants of COVID-19 vaccine rejection included the embrace of conspiratorial ideas regarding the virus and its vaccination. This should be considered in implementation of interventional measures aiming to promote COVID-19 vaccination in the country.", "doi": "10.1016/j.vacun.2022.04.003", "pmid": "35813989", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1576-9887(22)00039-5"}, {"db": "pmc", "key": "PMC9256516"}], "notes": [], "created": "2022-08-17T10:38:52.801Z", "modified": "2022-08-17T10:38:52.837Z"}, {"entity": "publication", "iuid": "0d15c6a7e22d443f955437406fe427cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d15c6a7e22d443f955437406fe427cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d15c6a7e22d443f955437406fe427cf"}}, "title": "COVID-19 Impact on Household Food Security in Urban and Peri-Urban Areas of Hyderabad, India.", "authors": [{"family": "Padmaja", "given": "Ravula", "initials": "R"}, {"family": "Nedumaran", "given": "Swamikannu", "initials": "S"}, {"family": "Jyosthnaa", "given": "Padmanabhan", "initials": "P"}, {"family": "Kavitha", "given": "Kasala", "initials": "K"}, {"family": "Abu Hatab", "given": "Assem", "initials": "A"}, {"family": "Lagerkvist", "given": "Carl-Johan", "initials": "CJ"}], "type": "journal article", "published": "2022-05-13", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "10", "pages": "814112", "issn-l": "2296-2565"}, "abstract": "This paper investigates the impact of the COVID-19 pandemic on food security and on coping-strategies in urban and peri-urban areas of the Hyderabad, India. Household survey data were collected before (October 2018) and during (January 2021) the onset of the pandemic. Results from logistic regression with the standarized Food Insecurity Expecience Scale (FIES) as dependent variable reveal that close to 40% of the households surveyed experienced a deterioration in food security status during the pandemic. In particular, we find that food security is closely related to the sector of employment in which the primary income- earning member of a household is engaged. To mitigate the impact of the pandemic on their food security, our sampled households adopted a variety of consumption-smoothing strategies including availing credit from both formal and informal sources, and liquidating their savings. Compared to households with severe or moderate level of food insecurity, households facing a mild level of food insecurity relied on stored food as a strategy to smoothen consumption in response to the income shock imparted by the pandemic. In addition, the results indicate that urban households, who adopted similar coping strategies as those adopted by peri-urban households, tended to be more food-insecure. Finally, the duration of unemployment experienced during the pandemic significantly influenced the status of household food security. These findings can inform the formulation of immediate and medium-term policy responses, including social protection policies conductive to mitigating the impacts of the COVID-19 pandemic and ameliorating the governance of urban food security during unexpected events and shocks.", "doi": "10.3389/fpubh.2022.814112", "pmid": "35646805", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9136225"}], "notes": [], "created": "2022-06-21T17:33:21.216Z", "modified": "2022-06-21T17:33:21.232Z"}, {"entity": "publication", "iuid": "50a3e8646978441c839206df02532bc5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50a3e8646978441c839206df02532bc5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50a3e8646978441c839206df02532bc5"}}, "title": "Quality of the Healthcare Services During COVID-19 Pandemic in Selected European Countries.", "authors": [{"family": "Tuczy\u0144ska", "given": "Magdalena", "initials": "M"}, {"family": "Staszewski", "given": "Rafa\u0142", "initials": "R"}, {"family": "Matthews-Kozanecka", "given": "Maja", "initials": "M"}, {"family": "\u017bok", "given": "Agnieszka", "initials": "A"}, {"family": "Baum", "given": "Ewa", "initials": "E"}], "type": "journal article", "published": "2022-05-12", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "10", "pages": "870314", "issn-l": "2296-2565"}, "abstract": "There are several definitions of the quality of healthcare services. It may be defined as a level of value provided by any health care resource, as determined by some measurement. Scientists use a variety of quality measures to attempt to determine health care quality. They use special indicators or based on a patients' or healthcare professional's perception. This article aims to provide a short review of the available data on the quality of healthcare services in selected European countries during the COVID-19 pandemic.\n\nThe research was done by the use of online databases such as PubMed, Google Scholar, and Science Direct. All the studies focused on the quality of healthcare services, yet the studies used different methods to measure this quality. In addition, the results of the authors' survey on the assessment of the quality of healthcare services before and during the COVID-19 pandemic were presented.\n\nAmong twelve studies, four were from the United Kingdom and one each of Catalonia, Italy, Sweden, Poland, Netherlands, France, Germany, Belgium. Patients in the United Kingdom felt that the quality of services was good during the pandemic, whereas the quality declined in the other studies cited. The results of our research also revealed a decrease in the quality of healthcare services provided.\n\nNevertheless the development of telemedicine has had a positive impact on the quality of healthcare services. The COVID-19 pandemic has undoubtedly affected most European countries' quality of healthcare services.", "doi": "10.3389/fpubh.2022.870314", "pmid": "35646786", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9133554"}], "notes": [], "created": "2022-06-21T17:33:41.928Z", "modified": "2022-06-21T17:33:41.942Z"}, {"entity": "publication", "iuid": "4771805ee90843d9ae54590d2abd7a7b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4771805ee90843d9ae54590d2abd7a7b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4771805ee90843d9ae54590d2abd7a7b"}}, "title": "Barriers and Facilitators to Receiving the COVID-19 Vaccination and Development of Theoretically-Informed Implementation Strategies for the Public: Qualitative Study in Hong Kong.", "authors": [{"family": "Wong", "given": "Charlene Hl", "initials": "CH", "orcid": "0000-0003-2623-5855", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0db6ceb15388473bb3a8c6128aa67716.json"}}, {"family": "Zhong", "given": "Claire Cw", "initials": "CC"}, {"family": "Chung", "given": "Vincent Ch", "initials": "VC"}, {"family": "Nilsen", "given": "Per", "initials": "P"}, {"family": "Wong", "given": "Eliza Ly", "initials": "EL", "orcid": "0000-0001-9983-6219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32f2cac9d18445a7b5de24251c6f6be4.json"}}, {"family": "Yeoh", "given": "Eng-Kiong", "initials": "EK"}], "type": "journal article", "published": "2022-05-12", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "5", "issn-l": null}, "abstract": "enhancing uptake of COVID-19 vaccines is an important tool for managing the pandemic. However, in Hong Kong, the COVID-19 vaccination rate in the general population was unsatisfactory during the early phase of the vaccination program. This two-part study aimed to (i) identify barriers and facilitators to receiving vaccinations, and (ii) develop theoretically-informed implementation strategies for promoting uptake.\n\nin part 1, 45 Hong Kong residents who differed in their willingness to vaccinate (willing (n = 15), were unwilling (n = 15), and were hesitant (n = 15)), were interviewed individually in February 2021. They were invited to express their perceptions of receiving the COVID-19 vaccination. The theoretical domains framework (TDF) was applied to guide the interviews and analyses. Behavioral diagnoses from these findings were then used to develop theoretically-informed implementation strategies in part 2, composed of behavior change techniques (BCTs) informed by the established BCT taxonomy.\n\nin part 1, the five main barriers were (i) concerns on severe and long-term side effects; (ii) low confidence in the safety and effectiveness due to concerns of their accelerated development; (iii) unclear information on logistical arrangements of the vaccination program; (iv) insufficient data on safety and effectiveness; and (v) perceived low protection ability conferred by the vaccines. The five main facilitators included (i) healthcare professionals' recommendations; (ii) news from TV, radio, and newspapers as main sources of trustworthy information; (iii) vaccine-related health education delivered by healthcare professionals; (iv) expectations of resuming to a normal social life; and (v) perceived benefits outweighing risks of mild and short-term side effects.\n\nseven implementation strategies were developed in part 2 based on the results above, namely (i) providing trustworthy vaccine-related information and scaling up the promotion; (ii) encouraging healthcare professionals to recommend vaccinations; (iii) giving incentives; (iv) using social influence approaches; (v) allowing a selection of COVID-19 vaccine brands; (vi) increasing accessibility for vaccinations; and (vii) emphasizing social responsibility.", "doi": "10.3390/vaccines10050764", "pmid": "35632520", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "vaccines10050764"}], "notes": [], "created": "2022-06-21T17:39:57.144Z", "modified": "2022-06-21T17:40:13.283Z"}, {"entity": "publication", "iuid": "1b10339b6f5f442bbbd6b427f97707ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b10339b6f5f442bbbd6b427f97707ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b10339b6f5f442bbbd6b427f97707ff"}}, "title": "A Feasibility Study of a Remotely-Delivered Mindfulness-Based Training for Adolescents During the COVID-19 Pandemic.", "authors": [{"family": "Tymofiyeva", "given": "Olga", "initials": "O"}, {"family": "Hu", "given": "Melody Y", "initials": "MY"}, {"family": "Sipes", "given": "Benjamin S", "initials": "BS"}, {"family": "Jakary", "given": "Angela", "initials": "A"}, {"family": "Glidden", "given": "David V", "initials": "DV"}, {"family": "Jariwala", "given": "Namasvi", "initials": "N"}, {"family": "Bhandari", "given": "Sarina", "initials": "S"}, {"family": "Parks", "given": "Kendall C", "initials": "KC"}, {"family": "Nguyen", "given": "Ca", "initials": "C"}, {"family": "Henje", "given": "Eva", "initials": "E"}, {"family": "Yang", "given": "Tony T", "initials": "TT"}], "type": "journal article", "published": "2022-05-12", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "13", "pages": "838694", "issn-l": "1664-0640"}, "abstract": "Social distancing, home confinement, economic challenges, and COVID-19-related illness and deaths during the COVID-19 pandemic can significantly affect mental health in youth. One promising approach to reduce anxiety and depression in adolescents is the neuroscience-based mindfulness intervention Training for Awareness, Resilience, and Action (TARA). The objective of this individually randomized waitlist-controlled trial (RCT) was (1) to test the feasibility of TARA, delivered partially over Zoom, and (2) to assess changes in the emotional wellbeing in healthy adolescents between the ages of 14-18 years old during the COVID-19 pandemic.\n\nTwenty-one healthy adolescents were randomized to the TARA intervention or to the waitlist control group in February 2020, just before the start of the pandemic. The TARA group intervention was delivered in person for the first five sessions and remotely over Zoom for the remaining seven sessions due to the pandemic. The participants' acceptability of TARA was assessed weekly using the Child Session Rating Scale (CSRS). The primary outcome was the emotional wellbeing measured using emotional symptoms subscale of the Strengths and Difficulties Questionnaire (SDQ) pre/post-TARA. We also explored weekly changes in TARA participants' wellbeing using the Child Outcome Rating Scale (CORS).\n\nThe overall session rating in TARA participants improved after the switch to Zoom (Cohen's d = 1.2, p = 0.008). The results of the two-way ANOVA showed no statistically significant difference in the change of the SDQ emotional symptoms during the 12 weeks between the TARA group and waitlist-control group (timepoint \u00d7 group interaction: F = 0.77, p = 0.38). The exploratory analysis using the CORS in the TARA participants showed a significant improvement in their functioning over the weeks of training.\n\nOur results support the feasibility of TARA delivered over Zoom. While our primary outcome did not provide support for the improvement of the emotional wellbeing with TARA compared to a passive control group, our exploratory analysis in the intervention group indicated an improved functioning over the weeks of TARA training. The important general positive impact of this study lies in the possibility of offering a neuroscience-based mindfulness intervention remotely to youth living in remote areas and for all youth during pandemic times.", "doi": "10.3389/fpsyt.2022.838694", "pmid": "35633797", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9133427"}], "notes": [], "created": "2022-06-21T17:38:49.218Z", "modified": "2022-06-21T17:39:01.924Z"}, {"entity": "publication", "iuid": "588e28d247da46e8a413f4f2f7380555", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/588e28d247da46e8a413f4f2f7380555.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/588e28d247da46e8a413f4f2f7380555"}}, "title": "Comparison of years of life lost to 1,565 suicides versus 10,650 COVID-19 deaths in 2020 in Sweden: four times more years of life lost per suicide than per COVID-19 death.", "authors": [{"family": "Ljung", "given": "Rickard", "initials": "R", "orcid": "0000-0002-0654-4530", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ba40c2b98b1442192811ba44ffbf967.json"}}, {"family": "Gr\u00fcnewald", "given": "Maria", "initials": "M", "orcid": "0000-0002-9280-8140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c1e75524a543e6a9f6177f8d7791e2.json"}}, {"family": "Sundstr\u00f6m", "given": "Anders", "initials": "A", "orcid": "0000-0003-2337-3371", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5acbd5b816884f06807b23bd3e2e6cad.json"}}, {"family": "Sundbom", "given": "Lena Thunander", "initials": "LT"}, {"family": "Zethelius", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-1738-0834", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed68e20a415f43d4882fdb44c2e4ee21.json"}}], "type": "journal article", "published": "2022-05-11", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "volume": "127", "issn-l": "0300-9734"}, "abstract": "The burden of disease from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is large; however, suicide affects the population year after year. From a public health perspective, it is important to not neglect contributors to the total burden of disease. The aim of this paper is to compare years of life lost (YLL) to suicide with those lost to coronavirus disease 2019 (COVID-19).\n\nA nationwide cohort study in 2020, in Sweden. YLL was measured as the sex- and age-specific remaining life expectancy at the time of the person's death based on the death risks that pertained to the Swedish population in 2019. YLL to suicide was compared to YLL to COVID-19 and presented by sex and age groups. Suicide deaths in 2020 were estimated as the annual average of suicides in 2015-2019.\n\nAnnual average of suicide was 1,565, whereof 1,076 (68.8%) men and 489 (31.2%) women. In 2020, 10,650 persons died of COVID-19, whereof 5,681 (53.3%) men and 4,969 (46.7%) women. Estimated total YLL to suicide and COVID-19 in 2020 was 53,237 and 90,116, respectively. The COVID-19 YLL to suicide YLL ratio in 2020 was 1.69 (90,116/53,237). Men accounted for 67.1% of suicide YLL and of 56.4% of COVID-19 YLL. Those 44 years or younger accounted for 60.3% of suicide YLL and 3.9% of COVID-19 YLL. Those 75 years and older accounted for 2.9% of suicide YLL and 60.9% of COVID-19 YLL. On average, each suicide generates 34 YLL (53,237/1,565), and each COVID-19 death generates 8.5 YLL (90,116/10,650).\n\nYLL to suicide affects Sweden year after year, foremost attributable to the younger age groups, whereas YLL to COVID-19 is foremost attributable to the elderly. On average, each suicide generates four times more YLL than a COVID-19 death. Enormous efforts and resources have been put on tackling the pandemic, and without these, the burden would probably have been much larger. However, from a public health perspective, it is important to not neglect other contributors to the total burden of disease where national efforts also may have an impact.", "doi": "10.48101/ujms.v127.8533", "pmid": "35722184", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC9169542"}, {"db": "pii", "key": "8533"}], "notes": [], "created": "2022-06-20T18:04:55.929Z", "modified": "2023-01-13T13:40:05.469Z"}, {"entity": "publication", "iuid": "6f6f1f88f28e45819836de1ae35e3526", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f6f1f88f28e45819836de1ae35e3526.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f6f1f88f28e45819836de1ae35e3526"}}, "title": "Can diffusion tensor imaging (DTI) outperform standard magnetic resonance imaging (MRI) investigations in post-COVID-19 autoimmune encephalitis?", "authors": [{"family": "Latini", "given": "Francesco", "initials": "F", "orcid": "0000-0002-4702-526X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30e6260671fb44f4b80218f9acc037fd.json"}}, {"family": "Fahlstr\u00f6m", "given": "Markus", "initials": "M", "orcid": "0000-0002-2502-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce71adf67a984cf6aa8ec4a32cf1d664.json"}}, {"family": "F\u00e4llmar", "given": "David", "initials": "D", "orcid": "0000-0001-5615-2036", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08e1206ab94a43788a7fc641ee13407c.json"}}, {"family": "Marklund", "given": "Niklas", "initials": "N", "orcid": "0000-0002-9797-5626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b0d761a3f60485587650286412498b9.json"}}, {"family": "Cunningham", "given": "Janet L", "initials": "JL", "orcid": "0000-0001-7876-7779", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2f65143e6e34510a93df76eb96d0d7f.json"}}, {"family": "Feresiadou", "given": "Amalia", "initials": "A"}], "type": "journal article", "published": "2022-05-10", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "volume": "127", "issn-l": "0300-9734"}, "abstract": "Neurological and psychiatric manifestations related to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection are widely recognised. Standard magnetic resonance imaging (MRI) investigations are normal in 40-80% of symptomatic patients, eventually delaying appropriate treatment when MRI is unrevealing any structural changes. The aim of this study is to investigate white matter abnormalities during an early stage of post-COVID-19 (coronavirus disease 2019) encephalitis while conventional MRI was normal.\n\nA patient with post-COVID-19 autoimmune encephalitis was investigated by serial MRIs and diffusion tensor imaging (DTI). Ten healthy control individuals (HC) were utilised as a control group for the DTI analysis. Major projection, commissural and association white matter pathways were reconstructed, and multiple diffusion parameters were analysed and then compared to the HC average using a z-test for serial examinations.\n\nEleven days after the onset of neurological symptoms, DTI revealed early white matter changes, compared with HC, when standard MRI was normal. On day 68, DTI showed multiple white matter lesions compared with HC, visible at this time also by the MRI images, indicating inflammatory changes in different association and projection white matter pathways.\n\nWe confirm a limitation in the sensitivity of conventional MRI at the acute setting of post-COVID-19 autoimmune encephalitis. A complementary DTI investigation could be a valuable diagnostic tool in early therapeutic decisions concerning COVID-19-related neurological symptoms.", "doi": "10.48101/ujms.v127.8562", "pmid": "35722186", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "8562"}, {"db": "pmc", "key": "PMC9169543"}], "notes": [], "created": "2022-06-20T18:04:34.750Z", "modified": "2022-08-17T12:45:48.904Z"}, {"entity": "publication", "iuid": "24b14ce13196447b8ec446d4ed60d709", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24b14ce13196447b8ec446d4ed60d709.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24b14ce13196447b8ec446d4ed60d709"}}, "title": "Viral Antigen and Inflammatory Biomarkers in Cerebrospinal Fluid in Patients With COVID-19 Infection and Neurologic Symptoms Compared With Control Participants Without Infection or Neurologic Symptoms.", "authors": [{"family": "Ed\u00e9n", "given": "Arvid", "initials": "A"}, {"family": "Grahn", "given": "Anna", "initials": "A"}, {"family": "Bremell", "given": "Daniel", "initials": "D"}, {"family": "Aghvanyan", "given": "Anahit", "initials": "A"}, {"family": "Bathala", "given": "Pradeepthi", "initials": "P"}, {"family": "Fuchs", "given": "Dietmar", "initials": "D"}, {"family": "Gostner", "given": "Johanna", "initials": "J"}, {"family": "Hagberg", "given": "Lars", "initials": "L"}, {"family": "Kanberg", "given": "Nelly", "initials": "N"}, {"family": "Kanjananimmanont", "given": "Sunsanee", "initials": "S"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Misaghian", "given": "Salvia", "initials": "S"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Sch\u00f6ll", "given": "Michael", "initials": "M"}, {"family": "Sigal", "given": "George", "initials": "G"}, {"family": "Stentoft", "given": "Erika", "initials": "E"}, {"family": "Studahl", "given": "Marie", "initials": "M"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Wang", "given": "Mingyue", "initials": "M"}, {"family": "Stengelin", "given": "Martin", "initials": "M"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2022-05-02", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "volume": "5", "issue": "5", "pages": "e2213253", "issn-l": null}, "abstract": "Neurologic symptoms are common in COVID-19, but the central nervous system (CNS) pathogenesis is unclear, and viral RNA is rarely detected in cerebrospinal fluid (CSF).\n\nTo measure viral antigen and inflammatory biomarkers in CSF in relation to neurologic symptoms and disease severity.\n\nThis cross-sectional study was performed from March 1, 2020, to June 30, 2021, in patients 18 years or older who were admitted to Sahlgrenska University Hospital, Gothenburg, Sweden, with COVID-19. All patients had CSF samples taken because of neurologic symptoms or within a study protocol. Healthy volunteer and prepandemic control groups were included.\n\nSARS-CoV-2 infection.\n\nOutcomes included CSF SARS-CoV-2 nucleocapsid antigen (N-Ag) using an ultrasensitive antigen capture immunoassay platform and CSF biomarkers of immune activation (neopterin, \u03b22-microglobulin, and cytokines) and neuronal injury (neurofilament light protein [NfL]).\n\nForty-four patients (median [IQR] age, 57 [48-69] years; 30 [68%] male; 26 with moderate COVID-19 and 18 with severe COVID-19 based on the World Health Organization Clinical Progression Scale), 10 healthy controls (median [IQR] age, 58 [54-60] years; 5 [50%] male), and 41 patient controls (COVID negative without evidence of CNS infection) (median [IQR] age, 59 [49-70] years; 19 [46%] male) were included in the study. Twenty-one patients were neuroasymptomatic and 23 were neurosymptomatic (21 with encephalopathy). In 31 of 35 patients for whom data were available (89%), CSF N-Ag was detected; viral RNA test results were negative in all. Nucleocapsid antigen was significantly correlated with CSF neopterin (r = 0.38; P = .03) and interferon \u03b3 (r = 0.42; P = .01). No differences in CSF N-Ag concentrations were found between patient groups. Patients had markedly increased CSF neopterin, \u03b22-microglobulin, interleukin (IL) 2, IL-6, IL-10, and tumor necrosis factor \u03b1 compared with controls. Neurosymptomatic patients had significantly higher median (IQR) CSF interferon \u03b3 (86 [47-172] vs 21 [17-81] fg/mL; P = .03) and had a significantly higher inflammatory biomarker profile using principal component analysis compared with neuroasymptomatic patients (0.54; 95% CI, 0.03-1.05; P = .04). Age-adjusted median (IQR) CSF NfL concentrations were higher in patients compared with controls (960 [673-1307] vs 618 [489-786] ng/L; P = .002). No differences were seen in any CSF biomarkers in moderate compared with severe disease.\n\nIn this study of Swedish adults with COVID-19 infection and neurologic symptoms, compared with control participants, viral antigen was detectable in CSF and correlated with CNS immune activation. Patients with COVID-19 had signs of neuroaxonal injury, and neurosymptomatic patients had a more marked inflammatory profile that could not be attributed to differences in COVID-19 severity. These results highlight the clinical relevance of neurologic symptoms and suggest that viral components can contribute to CNS immune responses without direct viral invasion.", "doi": "10.1001/jamanetworkopen.2022.13253", "pmid": "35604688", "labels": {"Category: Biochemistry": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9127556"}, {"db": "pii", "key": "2792536"}], "notes": [], "created": "2022-06-21T17:54:22.642Z", "modified": "2023-06-19T14:45:22.640Z"}, {"entity": "publication", "iuid": "3739638ad7c44737924091555557a402", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3739638ad7c44737924091555557a402.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3739638ad7c44737924091555557a402"}}, "title": "Severe acute respiratory syndrome coronavirus 2 can be detected in exhaled aerosol sampled during a few minutes of breathing or coughing.", "authors": [{"family": "Viklund", "given": "Emilia", "initials": "E", "orcid": "0000-0003-4453-4680", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/332056bb6e88414d9f72c513b31c7959.json"}}, {"family": "Kokelj", "given": "Spela", "initials": "S"}, {"family": "Larsson", "given": "Per", "initials": "P"}, {"family": "Nord\u00e9n", "given": "Rickard", "initials": "R"}, {"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Beck", "given": "Olof", "initials": "O"}, {"family": "Westin", "given": "Johan", "initials": "J"}, {"family": "Olin", "given": "Anna-Carin", "initials": "AC"}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "Influenza Other Respir Viruses", "issn": "1750-2659", "volume": "16", "issue": "3", "pages": "402-410", "issn-l": null}, "abstract": "The knowledge on the concentration of viral particles in exhaled breath is limited. The aim of this study was to explore if severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be detected in aerosol from subjects with the coronavirus disease 2019 (COVID-19) during various types of breathing and coughing and how infection with SARS-CoV-2 may influence the number and size of exhaled aerosol particles.\n\nWe counted and collected endogenous particles in exhaled breath in subjects with COVID-19 disease by two different impaction-based methods, during 20 normal breaths, 10 airway opening breaths, and three coughs, respectively. Breath samples were analyzed with reverse transcription real-time polymerase chain reaction (RT-PCR).\n\nDetection of RNA in aerosol was possible in 10 out of 25 subjects. Presence of virus RNA in aerosol was mainly found in cough samples (n = 8), but also in airway opening breaths (n = 3) and in normal breaths (n = 4), with no overlap between the methods. No association between viral load in aerosol and number exhaled particles <5 \u03bcm was found. Subjects with COVID-19 exhaled less particles than healthy controls during normal breathing and airway opening breaths (all P < 0.05), but not during cough.\n\nSARS-CoV-2 RNA can be detected in exhaled aerosol, sampled during a limited number of breathing and coughing procedures. Detection in aerosol seemed independent of viral load in the upper airway swab as well as of the exhaled number of particles. The infectious potential of the amount of virus detected in aerosol needs to be further explored.", "doi": "10.1111/irv.12964", "pmid": "35037404", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8983906"}], "notes": [], "created": "2022-01-27T07:38:28.676Z", "modified": "2023-06-19T14:19:39.990Z"}, {"entity": "publication", "iuid": "a25e4faab1cd435db55f17485fb41713", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a25e4faab1cd435db55f17485fb41713.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a25e4faab1cd435db55f17485fb41713"}}, "title": "Potential neurological manifestations of COVID-19: a narrative review.", "authors": [{"family": "Pergolizzi", "given": "Joseph V", "initials": "JV", "orcid": "0000-0001-5658-1471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b411beeaa47641bca832e58b7c6a9a69.json"}}, {"family": "Raffa", "given": "Robert B", "initials": "RB", "orcid": "0000-0002-1456-4451", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040955e0221f405494e8870d61dc0378.json"}}, {"family": "Varrassi", "given": "Giustino", "initials": "G", "orcid": "0000-0002-3822-2923", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c88c160784934b09ae6e4d0303fc71b7.json"}}, {"family": "Magnusson", "given": "Peter", "initials": "P", "orcid": "0000-0001-7906-7782", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9484ae1472fe43b39127b01810ffff33.json"}}, {"family": "LeQuang", "given": "Jo Ann", "initials": "JA", "orcid": "0000-0003-4794-0318", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f96aac587798429da2324c43ad9813fa.json"}}, {"family": "Paladini", "given": "Antonella", "initials": "A", "orcid": "0000-0002-1219-9315", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/410a15dde4a84c92ab7c5700879accd8.json"}}, {"family": "Taylor", "given": "Robert", "initials": "R", "orcid": "0000-0001-5971-361X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21635cc313974dbabc0baaa7ac95f6f8.json"}}, {"family": "Wollmuth", "given": "Charles", "initials": "C"}, {"family": "Breve", "given": "Frank", "initials": "F"}, {"family": "Chopra", "given": "Maninder", "initials": "M"}, {"family": "Nalamasu", "given": "Rohit", "initials": "R"}, {"family": "Christo", "given": "Paul J", "initials": "PJ"}, {"family": "NEMA Research Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "Postgrad Med", "issn": "1941-9260", "volume": "134", "issue": "4", "pages": "395-405", "issn-l": "0032-5481"}, "abstract": "Neurological manifestations are increasingly reported in a subset of COVID-19 patients. Previous infections related to coronaviruses, namely Severe Acute Respiratory Syndrome (SARS) and Middle Eastern Respiratory Syndrome (MERS) also appeared to have neurological effects on some patients. The viruses associated with COVID-19 like that of SARS enters the body via the ACE-2 receptors in the central nervous system, which causes the body to balance an immune response against potential damage to nonrenewable cells. A few rare cases of neurological sequelae of SARS and MERS have been reported. A growing body of evidence is accumulating that COVID-19, particularly in severe cases, may have neurological consequences although respiratory symptoms nearly always develop prior to neurological ones. Patients with preexisting neurological conditions may be at elevated risk for COVID-19-associated neurological symptoms. Neurological reports in COVID-19 patients have described encephalopathy, Guillain-Barr\u00e9 syndrome, myopathy, neuromuscular disorders, encephalitis, cephalgia, delirium, critical illness polyneuropathy, and others. Treating neurological symptoms can pose clinical challenges as drugs that suppress immune response may be contraindicated in COVID-19 patients. It is possible that in some COVID-19 patients, neurological symptoms are being overlooked or misinterpreted. To date, neurological manifestations of COVID-19 have been described largely within the disease trajectory and the long-term effects of such manifestations remain unknown.", "doi": "10.1080/00325481.2020.1837503", "pmid": "33089707", "labels": {"Category: Social Science & Humanities": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7799377"}], "notes": [], "created": "2020-11-26T12:16:31.652Z", "modified": "2023-01-13T14:45:28.997Z"}, {"entity": "publication", "iuid": "fce5800c723041d8b1c9b8dcc8e7def2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fce5800c723041d8b1c9b8dcc8e7def2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fce5800c723041d8b1c9b8dcc8e7def2"}}, "title": "Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: Update of a living systematic review and meta-analysis.", "authors": [{"family": "Buitrago-Garcia", "given": "Diana", "initials": "D", "orcid": "0000-0001-9761-206X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21246f1ed5d94488a97190a5e92f5488.json"}}, {"family": "Ipekci", "given": "Aziz Mert", "initials": "AM", "orcid": "0000-0002-0260-9691", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee8671294d5b43f48f76a93236a723be.json"}}, {"family": "Heron", "given": "Leonie", "initials": "L", "orcid": "0000-0002-3820-3343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/873b10a6c024425ebb7c8f6d994ed029.json"}}, {"family": "Imeri", "given": "Hira", "initials": "H", "orcid": "0000-0002-0412-1649", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f82db58c6c3e4bf48102085c1e24bd92.json"}}, {"family": "Araujo-Chaveron", "given": "Lucia", "initials": "L", "orcid": "0000-0002-2110-6088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54a422a247ea4393a3d7383d849f4e18.json"}}, {"family": "Arevalo-Rodriguez", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-7326-4504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28523e3462094df0ad816c3ca1b3cd3d.json"}}, {"family": "Ciapponi", "given": "Agust\u00edn", "initials": "A", "orcid": "0000-0001-5142-6122", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6493e266d9ec4eb0b2b206381516844b.json"}}, {"family": "Cevik", "given": "Muge", "initials": "M", "orcid": "0000-0003-1133-3874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90cabaf2381c4667aa0d4515fc2f3db2.json"}}, {"family": "Hauser", "given": "Anthony", "initials": "A", "orcid": "0000-0002-7221-1929", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4ad8a25f2854575af40c39f93c4c3ac.json"}}, {"family": "Alam", "given": "Muhammad Irfanul", "initials": "MI", "orcid": "0000-0002-8759-6585", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49edca8da0c3453f834d1fec4dfe3876.json"}}, {"family": "Meili", "given": "Kaspar", "initials": "K", "orcid": "0000-0002-9889-4406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a334f6359cd5436fa748f503c5ac24b6.json"}}, {"family": "Meyerowitz", "given": "Eric A", "initials": "EA", "orcid": "0000-0001-7954-6548", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b77f4eeebd94156bfd8b53716a61050.json"}}, {"family": "Prajapati", "given": "Nirmala", "initials": "N", "orcid": "0000-0001-7518-5968", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b573d28168b452aa168f42889153333.json"}}, {"family": "Qiu", "given": "Xueting", "initials": "X", "orcid": "0000-0001-6810-7304", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5eb2980535d4f9a8f6b8b02714545d0.json"}}, {"family": "Richterman", "given": "Aaron", "initials": "A", "orcid": "0000-0001-7920-7191", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13a2fc1e9cba4e16b79ebe473914d3ef.json"}}, {"family": "Robles-Rodriguez", "given": "William Gildardo", "initials": "WG", "orcid": "0000-0002-8383-6844", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c037505a5854c7cb4cc15f4a2c8505d.json"}}, {"family": "Thapa", "given": "Shabnam", "initials": "S"}, {"family": "Zhelyazkov", "given": "Ivan", "initials": "I", "orcid": "0000-0001-6320-7517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d3019d0c667b4d2a9cfc66e2f8cd1541.json"}}, {"family": "Salanti", "given": "Georgia", "initials": "G", "orcid": "0000-0002-3830-8508", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80f3be926d9c4f1a81d9a5ff4717a432.json"}}, {"family": "Low", "given": "Nicola", "initials": "N", "orcid": "0000-0003-4817-8986", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/acef6c2aaf2c4673be2ffe2e3dc5c17d.json"}}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "PLoS Med", "issn": "1549-1676", "volume": "19", "issue": "5", "pages": "e1003987", "issn-l": "1549-1277"}, "abstract": "Debate about the level of asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection continues. The amount of evidence is increasing and study designs have changed over time. We updated a living systematic review to address 3 questions: (1) Among people who become infected with SARS-CoV-2, what proportion does not experience symptoms at all during their infection? (2) What is the infectiousness of asymptomatic and presymptomatic, compared with symptomatic, SARS-CoV-2 infection? (3) What proportion of SARS-CoV-2 transmission in a population is accounted for by people who are asymptomatic or presymptomatic?\n\nThe protocol was first published on 1 April 2020 and last updated on 18 June 2021. We searched PubMed, Embase, bioRxiv, and medRxiv, aggregated in a database of SARS-CoV-2 literature, most recently on 6 July 2021. Studies of people with PCR-diagnosed SARS-CoV-2, which documented symptom status at the beginning and end of follow-up, or mathematical modelling studies were included. Studies restricted to people already diagnosed, of single individuals or families, or without sufficient follow-up were excluded. One reviewer extracted data and a second verified the extraction, with disagreement resolved by discussion or a third reviewer. Risk of bias in empirical studies was assessed with a bespoke checklist and modelling studies with a published checklist. All data syntheses were done using random effects models. Review question (1): We included 130 studies. Heterogeneity was high so we did not estimate a mean proportion of asymptomatic infections overall (interquartile range (IQR) 14% to 50%, prediction interval 2% to 90%), or in 84 studies based on screening of defined populations (IQR 20% to 65%, prediction interval 4% to 94%). In 46 studies based on contact or outbreak investigations, the summary proportion asymptomatic was 19% (95% confidence interval (CI) 15% to 25%, prediction interval 2% to 70%). (2) The secondary attack rate in contacts of people with asymptomatic infection compared with symptomatic infection was 0.32 (95% CI 0.16 to 0.64, prediction interval 0.11 to 0.95, 8 studies). (3) In 13 modelling studies fit to data, the proportion of all SARS-CoV-2 transmission from presymptomatic individuals was higher than from asymptomatic individuals. Limitations of the evidence include high heterogeneity and high risks of selection and information bias in studies that were not designed to measure persistently asymptomatic infection, and limited information about variants of concern or in people who have been vaccinated.\n\nBased on studies published up to July 2021, most SARS-CoV-2 infections were not persistently asymptomatic, and asymptomatic infections were less infectious than symptomatic infections. Summary estimates from meta-analysis may be misleading when variability between studies is extreme and prediction intervals should be presented. Future studies should determine the asymptomatic proportion of SARS-CoV-2 infections caused by variants of concern and in people with immunity following vaccination or previous infection. Without prospective longitudinal studies with methods that minimise selection and measurement biases, further updates with the study types included in this living systematic review are unlikely to be able to provide a reliable summary estimate of the proportion of asymptomatic infections caused by SARS-CoV-2.\n\nOpen Science Framework (https://osf.io/9ewys/).", "doi": "10.1371/journal.pmed.1003987", "pmid": "35617363", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "PMEDICINE-D-22-00260"}], "notes": [], "created": "2022-06-21T17:47:28.227Z", "modified": "2022-06-21T17:47:28.928Z"}, {"entity": "publication", "iuid": "3a73765806e14038a7f427e6cfaeea2e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a73765806e14038a7f427e6cfaeea2e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a73765806e14038a7f427e6cfaeea2e"}}, "title": "Moral Distress Among Operating Room Personnel During the COVID-19 Pandemic: A Qualitative Study", "authors": [{"family": "Fagerdahl", "given": "Ann Mari", "initials": "AM", "orcid": "0000-0002-9170-581X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ade5aac0a60a4ad1b19ccef36320e13e.json"}}, {"family": "Torbj\u00f6rnsson", "given": "Eva", "initials": "E"}, {"family": "Gustavsson", "given": "Martina", "initials": "M", "orcid": "0000-0002-6193-6289", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/658c2b521a9142d494ee474d9944d5b7.json"}}, {"family": "\u00c4lg\u00e5", "given": "Andreas", "initials": "A"}], "type": "journal-article", "published": "2022-05-00", "journal": {"title": "Journal of Surgical Research", "issn": "0022-4804", "volume": "273", "pages": "110-118", "issn-l": null}, "abstract": "The ongoing COVID-19 pandemic has necessitated the reallocation of healthcare resources, and a minimization of elective activities. Healthcare personnel involved in COVID-19 care have been negatively affected by the associated excess stress. The existing COVID-19 research has focused on the experiences among healthcare personnel in general, and not particularly on the operating room team members, who have often been relocated to overburdened workplaces. Therefore, we aimed to explore the experiences in this particular group.\n\nThis study has a qualitative inductive design based on interviews with a strategic sample of 12 operating room team members: surgeons, anesthesiologist, specialist nurses, and nurse assistants. The interviews were analyzed using content analysis.\n\nThree themes were identified: \"Feeling safe in the familiar and anxiety in the unknown\", \"To be the ones left behind\", and \"The possibility for recuperation in a seemingly everlasting situation\". The participants described working hard, although their efforts were experienced as not enough according to their moral ideals. We interpreted this as feelings and signs of moral distress, a commonly described concept in previous studies during the COVID-19 pandemic, and a risk for burn out.\n\nThe operating room team members emphasized the negative stress of being in the unknown, performing work tasks in an unfamiliar place and situation, and experiencing conflicting feelings of relief and guilt. Organizational strategies toward a functional leadership and support should be emphasized. Such strategies might reduce the risk of psychological consequences such as burn out.", "doi": "10.1016/j.jss.2021.12.011", "pmid": "35033820", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0022-4804(21)00740-X"}, {"db": "pmc", "key": "PMC8692083"}], "notes": [], "created": "2022-01-27T07:48:44.330Z", "modified": "2022-06-21T18:15:28.541Z"}, {"entity": "publication", "iuid": "e714e24b70654a99a7bda77f7eb68634", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e714e24b70654a99a7bda77f7eb68634.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e714e24b70654a99a7bda77f7eb68634"}}, "title": "Envisioning sustainable and equitable World Health Assemblies.", "authors": [{"family": "Khorsand", "given": "Parnian", "initials": "P", "orcid": "0000-0002-5347-1629", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5bcdb597d56c4e2a9141a03c59902375.json"}}, {"family": "Chowdhury", "given": "Maisoon", "initials": "M"}, {"family": "Wyns", "given": "Arthur", "initials": "A"}, {"family": "Velin", "given": "Lotta", "initials": "L", "orcid": "0000-0002-1929-6011", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c5b0a7da8a4eb19b92be09bbbef9b1.json"}}, {"family": "Wangari", "given": "Marie-Claire", "initials": "MC", "orcid": "0000-0002-4529-8133", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31a1675605154adda9fef1e2b842a291.json"}}, {"family": "Cipriano", "given": "Gabriela", "initials": "G"}, {"family": "El Omrani", "given": "Omnia", "initials": "O", "orcid": "0000-0002-1655-1195", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4eaa1ea11e884f49a9c60f7f9cd2bc74.json"}}, {"family": "Patil", "given": "Poorvaprabha", "initials": "P"}, {"family": "van Daalen", "given": "Kim", "initials": "K"}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "7", "issue": "5", "issn-l": "2059-7908"}, "abstract": null, "doi": "10.1136/bmjgh-2022-009231", "pmid": "35613838", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2022-009231"}], "notes": [], "created": "2022-06-21T17:49:52.561Z", "modified": "2022-06-21T17:50:07.987Z"}, {"entity": "publication", "iuid": "3d935e59859c4024845fca7dd4df8caa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3d935e59859c4024845fca7dd4df8caa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3d935e59859c4024845fca7dd4df8caa"}}, "title": "Decidual stromal cell therapy for generalized lymphadenopathy as a special clinical manifestation of COVID-19 infection: A case report.", "authors": [{"family": "Pirsalehi", "given": "Ali", "initials": "A"}, {"family": "Soleimani", "given": "Masoud", "initials": "M"}, {"family": "Hajifathali", "given": "Abbas", "initials": "A"}, {"family": "Sadeghi", "given": "Behnam", "initials": "B"}, {"family": "Farhadihosseinabadi", "given": "Behrouz", "initials": "B"}, {"family": "Akhlaghi", "given": "Sedigheh Sadat", "initials": "SS"}, {"family": "Roshandel", "given": "Elham", "initials": "E", "orcid": "0000-0002-3698-4342", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e62f2dd66ca0485091e82ae8562d1505.json"}}], "type": "case reports", "published": "2022-05-00", "journal": {"title": "Clin Case Rep", "issn": "2050-0904", "volume": "10", "issue": "5", "pages": "e05851", "issn-l": null}, "abstract": "We are going through the greatest global health crisis of the last decades, the coronavirus disease 2019 (COVID-19) pandemic. It may cause morbidity and mortality in some cases, and there is no therapeutic approach with reproducible and favorable outcomes. As clinical manifestations differ from patient to patient, any report regarding clinical symptoms has been beneficial for early detection and treatment. Due to the immunomodulatory effect of mesenchymal stem cells (MSCs), MSCs-based therapy has been approved to be one of the therapeutic strategies for COVID-19 management. For the first time in the literature, we reported generalized lymphadenopathy with fever and no sign of respiratory distress in a 16-year-old patient with confirmed COVID-19 infection as the main clinical signs. We also introduce decidual stromal cells as a potential immunomodulatory treatment for COVID-19-infected patients.", "doi": "10.1002/ccr3.5851", "pmid": "35600010", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "CCR35851"}, {"db": "pmc", "key": "PMC9109646"}], "notes": [], "created": "2022-06-21T17:57:22.435Z", "modified": "2022-06-21T17:57:41.697Z"}, {"entity": "publication", "iuid": "8826996b9bfa4f1cb9689c5f1a4bd6b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8826996b9bfa4f1cb9689c5f1a4bd6b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8826996b9bfa4f1cb9689c5f1a4bd6b1"}}, "title": "Critical Influenza and COVID-19-A Comparative Nationwide Case-Control Study.", "authors": [{"family": "Larsson", "given": "Emma", "initials": "E"}, {"family": "Eriksson", "given": "Jesper", "initials": "J"}, {"family": "Eriksson", "given": "Mikael", "initials": "M"}, {"family": "Oldner", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "Crit Care Explor", "issn": "2639-8028", "volume": "4", "issue": "5", "pages": "e0705", "issn-l": null}, "abstract": "Refined knowledge of risk factors for critical influenza and COVID-19 may lead to improved understanding of pathophysiology and better pandemic preparedness.\n\nTo compare risk-factor profiles of patients admitted to intensive care with critical influenza and COVID-19.\n\nA nationwide retrospective matched case-control study, including all adults admitted to an ICU in Sweden with influenza or COVID-19 between 2014 and September 2020 and a matched control population (ratio 1:5, patients:controls).\n\nAdmission to an ICU. The study included 1,873 influenza and 2,567 COVID-19 ICU patients, and 9,365 and 12,835 controls, respectively, matched on sex, age, and geographical region. Influenza patients were older and less likely male, and carried a larger burden of comorbidity and a higher Simplified Acute Physiology Score III score, whereas short-term mortalities were similar when compared to COVID-19 patients. The risk-factor profiles at ICU admission were largely comparable including socioeconomic, psychiatric, and several somatic variables. Hypertension was a strong risk factor in critical COVID-19 patients compared with influenza. Nonglucocorticoid immunosuppressive therapy was associated with critical influenza but not COVID-19. Premorbid medication with statins and renin-angiotensin-aldosterone system inhibitors reduced the risk for both conditions, the opposite was a seen for glucocorticoid medication. Notably, medication with betablockers, oral anticoagulation, and platelet inhibitors reduced the risk of critical COVID-19 but not influenza.\n\nThe risk-factor profiles for critical influenza and COVID-19 were largely comparable; however, some important differences were noted. Hypertension was a stronger risk factor for developing critical COVID-19, whereas the use of betablockers, oral anticoagulants, and platelet inhibitors all reduced the risk of ICU admission for COVID-19 but not influenza. Findings possibly reflected differences in pathophysiological mechanisms between these conditions.", "doi": "10.1097/CCE.0000000000000705", "pmid": "35620773", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9113210"}], "notes": [], "created": "2022-06-21T17:46:41.918Z", "modified": "2022-06-21T17:46:54.296Z"}, {"entity": "publication", "iuid": "07b3875cd4054292815a8c4612d07501", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07b3875cd4054292815a8c4612d07501.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07b3875cd4054292815a8c4612d07501"}}, "title": "Convulsions in children with COVID-19 during the Omicron wave.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF", "orcid": "0000-0003-1024-5602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1d5e45881a7469ca20a0eb360d891cc.json"}}], "type": "case reports", "published": "2022-05-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": "111", "issue": "5", "pages": "1023-1026"}, "abstract": "Most children with COVID-19 have mild symptoms, but data on the Omicron variant are rare. This paper describes unexpected cases with convulsions during 1 week in January 2022.\n\nFour children with COVID-19 were admitted with convulsions to the paediatric department in \u00d6rebro, Sweden, when Omicron accounted for more than 98% of the country's COVID-19 cases. Three children tested positive for the virus, and one had clinical COVID-19. I was able to contact the parents of three boys, who gave consent for these case studies.\n\nTwo boys aged 3 and 21 months tested positive for the virus and a 14-year-old boy tested negative, but had a cold and family members who had tested positive. The teenager had a history of urinary tract infections, but the younger boys had no earlier comorbidities. None had a history of epilepsy or febrile convulsions. The younger children had a fever and the teenager had upper respiratory symptoms. The 3-month-old child had repeated convulsions for several hours, the 21-month-old had continuous convulsions for 15-20 min, and the teenager had a convulsion for 30-60 s, followed by uncharacteristic aggression.\n\nConvulsions may be a sign of the Omicron variant in children with COVID-19.", "doi": "10.1111/apa.16276", "pmid": "35098577", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Omicron VoC": null}, "xrefs": [{"db": "pmc", "key": "PMC9303202"}], "notes": [], "created": "2022-02-06T16:55:21.106Z", "modified": "2023-07-13T11:26:25.599Z"}, {"entity": "publication", "iuid": "4401467d26b944ba942c0ca2330ebac6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4401467d26b944ba942c0ca2330ebac6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4401467d26b944ba942c0ca2330ebac6"}}, "title": "Clinically observed deletions in SARS-CoV-2 Nsp1 affect its stability and ability to inhibit translation.", "authors": [{"family": "Kumar", "given": "Pravin", "initials": "P"}, {"family": "Schexnaydre", "given": "Erin", "initials": "E"}, {"family": "Rafie", "given": "Karim", "initials": "K"}, {"family": "Kurata", "given": "Tatsuaki", "initials": "T"}, {"family": "Terenin", "given": "Ilya", "initials": "I"}, {"family": "Hauryliuk", "given": "Vasili", "initials": "V", "orcid": "0000-0003-2389-5057", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1c92042b0bf4268a03534211e245236.json"}}, {"family": "Carlson", "given": "Lars-Anders", "initials": "LA", "orcid": "0000-0003-2342-6488", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79dd613daf254b33af16fafe01bf767c.json"}}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "FEBS Lett", "issn": "1873-3468", "volume": "596", "issue": "9", "pages": "1203-1213", "issn-l": null}, "abstract": "Nonstructural protein 1 (Nsp1) of SARS-CoV-2 inhibits host cell translation through an interaction between its C-terminal domain and the 40S ribosome. The N-terminal domain (NTD) of Nsp1 is a target of recurring deletions, some of which are associated with altered COVID-19 disease progression. Here, we characterize the efficiency of translational inhibition by clinically observed Nsp1 deletion variants. We show that a frequent deletion of residues 79-89 severely reduces the ability of Nsp1 to inhibit translation while not abrogating Nsp1 binding to the 40S. Notably, while the SARS-CoV-2 5' untranslated region enhances translation of mRNA, it does not protect from Nsp1-mediated inhibition. Finally, thermal stability measurements and structure predictions reveal a correlation between stability of the NTD and the efficiency of translation inhibition.", "doi": "10.1002/1873-3468.14354", "pmid": "35434785", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9081967"}], "notes": [], "created": "2022-10-13T12:59:32.403Z", "modified": "2022-10-13T12:59:32.530Z"}, {"entity": "publication", "iuid": "36edc1be7141435f9e1be136f7a7c17d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/36edc1be7141435f9e1be136f7a7c17d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/36edc1be7141435f9e1be136f7a7c17d"}}, "title": "Changes in Maternal Substance Use During the COVID-19 Pandemic.", "authors": [{"family": "Joyce", "given": "Kayla M", "initials": "KM"}, {"family": "Cameron", "given": "Emily E", "initials": "EE"}, {"family": "Sulymka", "given": "Julia", "initials": "J"}, {"family": "Protudjer", "given": "Jennifer L P", "initials": "JLP"}, {"family": "Roos", "given": "Leslie E", "initials": "LE"}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "J Stud Alcohol Drugs", "issn": "1938-4114", "volume": "83", "issue": "3", "pages": "352-357", "issn-l": null}, "abstract": "Maternal stress and mental health challenges have increased since the coronavirus disease 2019 (COVID-19) pandemic began. Experts are concerned about elevated substance use given its well-known association with negative emotions, but existing research has not examined substance use among mothers during the COVID-19 pandemic. This is a crucial next step to inform policy and service supports given links between maternal substance use and adverse family experiences.\n\nData were collected online between April 14 and 28, 2020. A total of 508 mothers (mean age = 34.8 years, SD = 5.1) with children 0-8 years old participated via the Parenting During the Pandemic study. Mothers self-reported substance use change and motivations for using substances, as well as mental health symptoms.\n\nOf participating mothers, 54.9% did not change, 39.2% increased, and 5.9% decreased their substance use. Findings indicated that mothers with an anxiety disorder or elevated anxiety symptoms were more likely to report increased substance use during the pandemic. Using substances to cope with anxiety, depression, and boredom was elevated among mothers self-reporting increased substance use during the pandemic versus those reporting no change or a decrease in usage. Using substances to cope with anxiety was a risk factor for increased substance use.\n\nMany mothers have increased their substance use since the onset of the COVID-19 pandemic. Results highlight the need to treat maternal anxiety and the importance of teaching mothers coping strategies, other than using substances, to reduce the incidence of increased substance use among mothers and its negative sequelae.", "doi": null, "pmid": "35590175", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T18:00:17.710Z", "modified": "2022-06-21T18:00:17.751Z"}, {"entity": "publication", "iuid": "2178f25932ef44ab8a94a9230fac5ac3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2178f25932ef44ab8a94a9230fac5ac3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2178f25932ef44ab8a94a9230fac5ac3"}}, "title": "Cardiac dysfunction and mortality in critically ill patients with COVID-19: A Swedish multicentre observational study.", "authors": [{"family": "Holmqvist", "given": "Jacob", "initials": "J"}, {"family": "Beck-Friis", "given": "Josefine", "initials": "J", "orcid": "0000-0003-2400-4092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3f3764c8d95410abc83f9c3cca2eaeb.json"}}, {"family": "Jensen", "given": "Carl", "initials": "C"}, {"family": "Dalla", "given": "Keti", "initials": "K", "orcid": "0000-0001-7367-2500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f1c43bc04bf49a7adc3559aa5deb916.json"}}, {"family": "M\u00e5rdstam", "given": "Simon", "initials": "S"}, {"family": "Christensen", "given": "Jens", "initials": "J"}, {"family": "Nord\u00e9n", "given": "Nina", "initials": "N"}, {"family": "Widing", "given": "Hannes", "initials": "H"}, {"family": "Ros\u00e9n-Wetterholm", "given": "Elin", "initials": "E"}, {"family": "Cavefors", "given": "Oscar", "initials": "O"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Redfors", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Oras", "given": "Jonatan", "initials": "J", "orcid": "0000-0001-8890-6752", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bcac0f5ee544c18ba18e949ce76d121.json"}}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "volume": "66", "issue": "5", "pages": "606-614", "issn-l": "0001-5172"}, "abstract": "The prevalence and importance of cardiac dysfunction in critically ill patients with COVID-19 in Sweden is not yet established. The aim of the study was to assess the prevalence of cardiac dysfunction and elevated pulmonary artery pressure (PAP), and its influence on mortality in patients with COVID-19 in intensive care in Sweden.\n\nThis was a multicentre observational study performed in five intensive care units (ICUs) in Sweden. Patients admitted to participating ICU with COVID-19 were examined with echocardiography within 72 h from admission and again after 4 to 7 days. Cardiac dysfunction was defined as left ventricular (LV) dysfunction (ejection fraction <50% and/or regional hypokinesia) or right ventricular (RV) dysfunction (defined as TAPSE <17 mm or visually assessed moderate/severe RV dysfunction).\n\nWe included 132 patients, of whom 127 (96%) were intubated. Cardiac dysfunction was found in 42 (32%) patients. Most patients had cardiac dysfunction at the first assessment (n = 35) while a few developed cardiac dysfunction later (n = 7) and some changed type of dysfunction (n = 3). LV dysfunction was found in 21 and RV dysfunction in 19 patients, while 5 patients had combined dysfunction. Elevated PAP was found in 34 patients (26%) and was more common in patients with RV dysfunction. RV dysfunction and elevated PAP were independently associated with an increased risk of death (OR 3.98, p = .013 and OR 3.88, p = .007, respectively).\n\nCardiac dysfunction occurs commonly in critically ill patients with COVID-19 in Sweden. RV dysfunction and elevated PAP are associated with an increased risk of death.", "doi": "10.1111/aas.14039", "pmid": "35122232", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9111275"}], "notes": [], "created": "2022-02-06T16:45:14.911Z", "modified": "2023-06-19T14:21:31.581Z"}, {"entity": "publication", "iuid": "7f77851d69024d19b295883953bc730d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f77851d69024d19b295883953bc730d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f77851d69024d19b295883953bc730d"}}, "title": "Acute COVID-19 severity and mental health morbidity trajectories in patient populations of six nations: an observational study.", "authors": [{"family": "Magn\u00fasd\u00f3ttir", "given": "Ingibj\u00f6rg", "initials": "I"}, {"family": "Lovik", "given": "Anik\u00f3", "initials": "A"}, {"family": "Unnarsd\u00f3ttir", "given": "Anna B\u00e1ra", "initials": "AB"}, {"family": "McCartney", "given": "Daniel", "initials": "D"}, {"family": "Ask", "given": "Helga", "initials": "H"}, {"family": "K\u00f5iv", "given": "Kadri", "initials": "K"}, {"family": "Christoffersen", "given": "Lea Arregui Nordahl", "initials": "LAN"}, {"family": "Johnson", "given": "Sverre Urnes", "initials": "SU"}, {"family": "Hauksd\u00f3ttir", "given": "Arna", "initials": "A"}, {"family": "Fawns-Ritchie", "given": "Chloe", "initials": "C"}, {"family": "Helenius", "given": "Dorte", "initials": "D"}, {"family": "Gonz\u00e1lez-Hij\u00f3n", "given": "Juan", "initials": "J"}, {"family": "Lu", "given": "Li", "initials": "L"}, {"family": "Ebrahimi", "given": "Omid V", "initials": "OV"}, {"family": "Hoffart", "given": "Asle", "initials": "A"}, {"family": "Porteous", "given": "David J", "initials": "DJ"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Jakobsd\u00f3ttir", "given": "J\u00f3hanna", "initials": "J"}, {"family": "Lehto", "given": "Kelli", "initials": "K"}, {"family": "Andreassen", "given": "Ole A", "initials": "OA"}, {"family": "Pedersen", "given": "Ole B V", "initials": "OBV"}, {"family": "Aspelund", "given": "Thor", "initials": "T"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur Anna", "initials": "UA"}, {"family": "COVIDMENT Collaboration", "given": "", "initials": ""}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "Lancet Public Health", "issn": "2468-2667", "volume": "7", "issue": "5", "pages": "e406-e416", "issn-l": null}, "abstract": "Long-term mental and physical health consequences of COVID-19 (long COVID) are a persistent public health concern. Little is still known about the long-term mental health of non-hospitalised patients with COVID-19 with varying illness severities. Our aim was to assess the prevalence of adverse mental health symptoms among individuals diagnosed with COVID-19 in the general population by acute infection severity up to 16 months after diagnosis.\n\nThis observational follow-up study included seven prospectively planned cohorts across six countries (Denmark, Estonia, Iceland, Norway, Sweden, and the UK). Participants were recruited from March 27, 2020, to Aug 13, 2021. Individuals aged 18 years or older were eligible to participate. In a cross-sectional analysis, we contrasted symptom prevalence of depression, anxiety, COVID-19-related distress, and poor sleep quality (screened with validated mental health instruments) among individuals with and without a diagnosis of COVID-19 at entry, 0-16 months from diagnosis. In a cohort analysis, we further used repeated measures to estimate the change in mental health symptoms before and after COVID-19 diagnosis.\n\nThe analytical cohort consisted of 247 249 individuals, 9979 (4\u00b70%) of whom were diagnosed with COVID-19 during the study period. Mean follow-up was 5\u00b765 months (SD 4\u00b726). Participants diagnosed with COVID-19 presented overall with a higher prevalence of symptoms of depression (prevalence ratio [PR] 1\u00b718 [95% CI 1\u00b703-1\u00b736]) and poorer sleep quality (1\u00b713 [1\u00b703-1\u00b724]) but not symptoms of anxiety (0\u00b797 [0\u00b791-1\u00b703]) or COVID-19-related distress (1\u00b705 [0\u00b793-1\u00b720]) compared with individuals without a COVID-19 diagnosis. Although the prevalence of depression and COVID-19-related distress attenuated with time, individuals diagnosed with COVID-19 but never bedridden due to their illness were consistently at lower risk of depression (PR 0\u00b783 [95% CI 0\u00b775-0\u00b791]) and anxiety (0\u00b777 [0\u00b763-0\u00b794]) than those not diagnosed with COVID-19, whereas patients who were bedridden for more than 7 days were persistently at higher risk of symptoms of depression (PR 1\u00b761 [95% CI 1\u00b727-2\u00b705]) and anxiety (1\u00b743 [1\u00b726-1\u00b763]) than those not diagnosed throughout the study period.\n\nSevere acute COVID-19 illness-indicated by extended time bedridden-is associated with long-term mental morbidity among recovering individuals in the general population. These findings call for increased vigilance of adverse mental health development among patients with a severe acute disease phase of COVID-19.\n\nNordforsk, Horizon2020, Wellcome Trust, and Estonian Research Council.", "doi": "10.1016/S2468-2667(22)00042-1", "pmid": "35298894", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8920517"}, {"db": "pii", "key": "S2468-2667(22)00042-1"}], "notes": [], "created": "2023-02-13T18:38:15.520Z", "modified": "2023-02-13T18:38:15.523Z"}, {"entity": "publication", "iuid": "63501e894e164b0bbdb771e6aed8e8cd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63501e894e164b0bbdb771e6aed8e8cd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63501e894e164b0bbdb771e6aed8e8cd"}}, "title": "Changes in dementia diagnoses in Sweden during the COVID-19 pandemic.", "authors": [{"family": "Axenhus", "given": "Michael", "initials": "M"}, {"family": "Schedin-Weiss", "given": "Sophia", "initials": "S"}, {"family": "Tjernberg", "given": "Lars", "initials": "L"}, {"family": "Wimo", "given": "Anders", "initials": "A"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}, {"family": "Bucht", "given": "Gustaf", "initials": "G"}, {"family": "Winblad", "given": "Bengt", "initials": "B"}], "type": "journal article", "published": "2022-04-26", "journal": {"title": "BMC Geriatr", "issn": "1471-2318", "volume": "22", "issue": "1", "pages": "365", "issn-l": null}, "abstract": "The COVID-19 pandemic has caused large disruptions to healthcare systems. Refocus on COVID-19 related care might have contributed to indirect effects on other healthcare areas. Care focused on acute conditions have been negatively affected although research into the effects on chronic and care intensive patient groups such as patients with dementia diseases is lacking. In this study we evaluated dementia diagnosis trends in Sweden during 2015-2020 according to International Classification of Disease version 10 coding of common dementia diseases.\n\nRegional and national statistics in the form of International Classification of Disease version 10 coding, COVID-19 incidence, mortality data, and population census data were collected from the National Institute of Health and Welfare. Logistic regression analysis was performed to identify trends of dementia diagnosis during 2015-2020. Correlation test was performed between COVID-19 incidence, mortality rates, and dementia coding.\n\nDementia diagnosis incidence has been declining since 2015 and further decline was noted in many regions in Sweden during 2020. As COVID-19 incidence increased, fewer cases of dementia were diagnosed, a decrease that differentially impacted women and those who were advanced in age.\n\nDementia diagnosis incidence in Sweden has been on a decline since 2015. The COVID-19 pandemic caused a further larger decline in dementia diagnosis incidence during 2020. COVID-19 incidence, but not mortality, was associated with decrease in dementia diagnosis incidence. There might be a large number of undiagnosed patients with dementia and healthcare reforms should be enacted to address this. Women and elderly are particularly vulnerable groups.", "doi": "10.1186/s12877-022-03070-y", "pmid": "35473668", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9039601"}, {"db": "pii", "key": "10.1186/s12877-022-03070-y"}], "notes": [], "created": "2023-01-13T13:24:16.248Z", "modified": "2023-07-13T11:28:31.916Z"}, {"entity": "publication", "iuid": "07a7aba3e7594af8a3d7070d543d7b60", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07a7aba3e7594af8a3d7070d543d7b60.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07a7aba3e7594af8a3d7070d543d7b60"}}, "title": "Characterization of the Upper Respiratory Bacterial Microbiome in Critically Ill COVID-19 Patients.", "authors": [{"family": "Bai", "given": "Xiangning", "initials": "X"}, {"family": "Narayanan", "given": "Aswathy", "initials": "A"}, {"family": "Skagerberg", "given": "Magdalena", "initials": "M"}, {"family": "Ce\u00f1a-Diez", "given": "Rafael", "initials": "R", "orcid": "0000-0001-9987-395X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dd115af211249249702e843a35ca885.json"}}, {"family": "Giske", "given": "Christian G", "initials": "CG"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2022-04-23", "journal": {"title": "Biomedicines", "issn": "2227-9059", "volume": "10", "issue": "5", "issn-l": null}, "abstract": "The upper respiratory tract (URT) microbiome can contribute to the acquisition and severity of respiratory viral infections. The described associations between URT microbiota and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are limited at microbiota genus level and by the lack of functional interpretation. Our study, therefore, characterized the URT bacterial microbiome at species level and their encoded pathways in patients with COVID-19 and correlated these to clinical outcomes. Whole metagenome sequencing was performed on nasopharyngeal samples from hospitalized patients with critical COVID-19 (n = 37) and SARS-CoV-2-negative individuals (n = 20). Decreased bacterial diversity, a reduction in commensal bacteria, and high abundance of pathogenic bacteria were observed in patients compared to negative controls. Several bacterial species and metabolic pathways were associated with better respiratory status and lower inflammation. Strong correlations were found between species biomarkers and metabolic pathways associated with better clinical outcome, especially Moraxella lincolnii and pathways of vitamin K2 biosynthesis. Our study demonstrates correlations between the URT microbiome and COVID-19 patient outcomes; further studies are warranted to validate these findings and to explore the causal roles of the identified microbiome biomarkers in COVID-19 pathogenesis.", "doi": "10.3390/biomedicines10050982", "pmid": "35625719", "labels": {"Type: Journal article": null, "Category: Health": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "biomedicines10050982"}], "notes": [], "created": "2022-06-21T17:41:02.435Z", "modified": "2022-06-21T17:42:47.714Z"}, {"entity": "publication", "iuid": "0ec5c2cac37d43749d6f318b8a2c95a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ec5c2cac37d43749d6f318b8a2c95a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ec5c2cac37d43749d6f318b8a2c95a0"}}, "title": "Impact of Long COVID on health and quality of life.", "authors": [{"family": "O' Mahony", "given": "Liam", "initials": "L", "orcid": "0000-0003-4705-3583", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff1b8e3e2a0740c2b80dfc33eb95918c.json"}}, {"family": "Buwalda", "given": "Tanja", "initials": "T", "orcid": "0000-0003-1759-1348", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f77991bf89546659fcad40626ce0337.json"}}, {"family": "Blair", "given": "Matthew", "initials": "M"}, {"family": "Forde", "given": "Brian", "initials": "B"}, {"family": "Lunjani", "given": "Nonhlanhla", "initials": "N"}, {"family": "Ambikan", "given": "Anoop", "initials": "A"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U", "orcid": "0000-0002-0844-3338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5c27a627463945d992d74005f8a60d88.json"}}, {"family": "Barrett", "given": "Peter", "initials": "P", "orcid": "0000-0002-9637-9603", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae6be9f9cf2742c1a5ac01083e07d287.json"}}, {"family": "Geary", "given": "Eoin", "initials": "E"}, {"family": "O'Connor", "given": "Nuala", "initials": "N"}, {"family": "Dineen", "given": "Jennifer", "initials": "J"}, {"family": "Clarke", "given": "Gerard", "initials": "G"}, {"family": "Kelleher", "given": "Eric", "initials": "E"}, {"family": "Horgan", "given": "Mary", "initials": "M"}, {"family": "Jackson", "given": "Arthur", "initials": "A"}, {"family": "Sadlier", "given": "Corinna", "initials": "C", "orcid": "0000-0002-8415-2022", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/036863e36b4d4480b10efc5e1cd8a025.json"}}], "type": "journal article", "published": "2022-04-22", "journal": {"title": "HRB Open Res", "issn": "2515-4826", "volume": "5", "pages": "31", "issn-l": null}, "abstract": "Background: The aim of this study was to measure the impact of post-acute sequelae of COVID-19 (PASC) on quality of life, mental health, ability to work and return to baseline health in an Irish cohort. Methods: We invited individuals with symptoms of COVID-19 lasting more than 14 days to participate in an anonymous online questionnaire. Basic demographic data and self-reported symptoms were recorded. Internationally validated instruments including the patient health questionnaire somatic, anxiety and depressive symptom scales (PHQ-SADS), the Patient Health Questionnaire-15 (PHQ-15) and Chadler fatigue scale (CFQ) were used. Results: We analysed responses from 988 participants with self-reported confirmed (diagnostic/antibody positive; 81%) or suspected (diagnostic/antibody negative or untested; 9%) COVID-19. The majority of respondents were female (88%), white (98%), with a median age of 43.0 (range 15 - 88 years old) and a median BMI of 26.0 (range 16 - 60). At the time of completing this survey, 89% of respondents reported that they have not returned to their pre-COVID-19 level of health. The median number of symptoms reported was 8 (range 0 to 33 symptoms), with a median duration of 12 months (range 1 to 20 months) since time of acute infection. A high proportion of PASC patients reported that they have a moderate or severe limitation in their ability to carry out their usual activities, 38% report their ability to work is severely limited and 33% report a moderate, or higher, level of anxiety or depression. Conclusion: The results of this survey of an Irish cohort with PASC are in line with reports from other settings, and we confirm that patients with PASC reported prolonged, multi-system symptoms which can significantly impact quality of life, affect ability to work and cause significant disability. Dedicated multidisciplinary, cross specialty supports are required to improve outcomes of this patient group.", "doi": "10.12688/hrbopenres.13516.1", "pmid": "36101871", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9440374"}, {"db": "figshare", "key": "10.6084/m9.figshare.19364828.v1"}], "notes": [], "created": "2022-10-13T13:30:19.780Z", "modified": "2022-10-13T13:30:19.933Z"}, {"entity": "publication", "iuid": "4b983ed275bb4432b5d9c6b0caa293f5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b983ed275bb4432b5d9c6b0caa293f5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b983ed275bb4432b5d9c6b0caa293f5"}}, "title": "App-based COVID-19 syndromic surveillance and prediction of hospital admissions in COVID Symptom Study Sweden.", "authors": [{"family": "Kennedy", "given": "Beatrice", "initials": "B", "orcid": "0000-0002-0066-4814", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d3a346caa424c4dad653097b2518efb.json"}}, {"family": "Fitipaldi", "given": "Hugo", "initials": "H", "orcid": "0000-0001-5352-2134", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3dc5e2fbac6748eaa733dc8ee1abdfa8.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U"}, {"family": "Maziarz", "given": "Marlena", "initials": "M", "orcid": "0000-0003-1417-6050", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89782e93a17a4b44a89ad63cd80cce7f.json"}}, {"family": "Tsereteli", "given": "Neli", "initials": "N"}, {"family": "Oskolkov", "given": "Nikolay", "initials": "N", "orcid": "0000-0001-5326-8893", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c7eace8c27946a0b98ef5fcba466b0d.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G", "orcid": "0000-0002-3320-2448", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73494da542e8482694f425eb2de5d52d.json"}}, {"family": "Franks", "given": "Camilla A", "initials": "CA"}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c29a5a2d88b0407ba2e3d62baffffa3e.json"}}, {"family": "Spiliopoulos", "given": "Lampros", "initials": "L"}, {"family": "Adami", "given": "Hans-Olov", "initials": "HO", "orcid": "0000-0001-9592-5791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba3e4202c4be46ed9a2836ba631dce1e.json"}}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J", "orcid": "0000-0003-1883-2000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e88fdca336ae41c891f0a46e2481b67f.json"}}, {"family": "Engblom", "given": "Stefan", "initials": "S", "orcid": "0000-0002-3614-1732", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2d5c78e143c44eba2f0e8b463cefc5d.json"}}, {"family": "Fall", "given": "Katja", "initials": "K", "orcid": "0000-0002-3649-2639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa0adf9b952e4e998c4a2deb07be5907.json"}}, {"family": "Grimby-Ekman", "given": "Anna", "initials": "A", "orcid": "0000-0002-9408-6065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c55950a9f1f4f868363a84975157fe4.json"}}, {"family": "Litton", "given": "Jan-Eric", "initials": "JE"}, {"family": "Martinell", "given": "Mats", "initials": "M"}, {"family": "Oudin", "given": "Anna", "initials": "A", "orcid": "0000-0002-9876-0627", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46d26c6a20434968a730560fb7b160a2.json"}}, {"family": "Sj\u00f6str\u00f6m", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Timpka", "given": "Toomas", "initials": "T", "orcid": "0000-0001-6049-5402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebcb4fac20f845a4bd9eaa4bf1660ebb.json"}}, {"family": "Sudre", "given": "Carole H", "initials": "CH", "orcid": "0000-0001-5753-428X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c26472813fed4007a8757af771de1802.json"}}, {"family": "Graham", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-4170-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f5f4e19812a46ed9e873732ec25e28d.json"}}, {"family": "du Cadet", "given": "Julien Lavigne", "initials": "JL"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "Davies", "given": "Richard", "initials": "R", "orcid": "0000-0003-2050-3994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b82cc92615f462d9af0153a6fb94fde.json"}}, {"family": "Ganesh", "given": "Sajaysurya", "initials": "S"}, {"family": "May", "given": "Anna", "initials": "A"}, {"family": "Ourselin", "given": "S\u00e9bastien", "initials": "S", "orcid": "0000-0002-5694-5340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74c7b9b1633144879042d198c7205656.json"}}, {"family": "Pujol", "given": "Joan Capdevila", "initials": "JC"}, {"family": "Selvachandran", "given": "Somesh", "initials": "S"}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}, {"family": "Gomez", "given": "Maria F", "initials": "MF", "orcid": "0000-0001-6210-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e09e37219c4f42c8a7b3a982da523859.json"}}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74cf1f7094744ee289fa5df041e7cb5b.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f34c0d3602439abe6096293c7c732d.json"}}], "type": "journal article", "published": "2022-04-21", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "13", "issue": "1", "pages": "2110"}, "abstract": "The app-based COVID Symptom Study was launched in Sweden in April 2020 to contribute to real-time COVID-19 surveillance. We enrolled 143,531 study participants (\u226518 years) who contributed 10.6 million daily symptom reports between April 29, 2020 and February 10, 2021. Here, we include data from 19,161 self-reported PCR tests to create a symptom-based model to estimate the individual probability of symptomatic COVID-19, with an AUC of 0.78 (95% CI 0.74-0.83) in an external dataset. These individual probabilities are employed to estimate daily regional COVID-19 prevalence, which are in turn used together with current hospital data to predict next week COVID-19 hospital admissions. We show that this hospital prediction model demonstrates a lower median absolute percentage error (MdAPE: 25.9%) across the five most populated regions in Sweden during the first pandemic wave than a model based on case notifications (MdAPE: 30.3%). During the second wave, the error rates are similar. When we apply the same model to an English dataset, not including local COVID-19 test data, we observe MdAPEs of 22.3% and 19.0% during the first and second pandemic waves, respectively, highlighting the transferability of the prediction model.", "doi": "10.1038/s41467-022-29608-7", "pmid": "35449172", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9023535"}, {"db": "pii", "key": "10.1038/s41467-022-29608-7"}], "notes": [], "created": "2021-06-23T07:15:51.852Z", "modified": "2023-01-13T13:31:54.600Z"}, {"entity": "publication", "iuid": "a6fbf67199f54aef93b69717f097602d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6fbf67199f54aef93b69717f097602d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6fbf67199f54aef93b69717f097602d"}}, "title": "Uncontrolled asthma predicts severe COVID-19: a report from the Swedish National Airway Register.", "authors": [{"family": "Karlsson Sundbaum", "given": "Johanna", "initials": "J", "orcid": "0000-0001-5313-7981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8b5dfbfb761446aa474013fcccdd085.json"}}, {"family": "Konradsen", "given": "Jon R", "initials": "JR"}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW"}, {"family": "Axelsson Fisk", "given": "Sten", "initials": "S"}, {"family": "Pedroletti", "given": "Christophe", "initials": "C"}, {"family": "Sj\u00f6\u00f6", "given": "Yvonne", "initials": "Y"}, {"family": "Syk", "given": "J\u00f6rgen", "initials": "J"}, {"family": "Sterner", "given": "Therese", "initials": "T"}, {"family": "Lindberg", "given": "Anne", "initials": "A"}, {"family": "Tuns\u00e4ter", "given": "Alf", "initials": "A"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ekberg-Jansson", "given": "Ann", "initials": "A"}, {"family": "Stridsman", "given": "Caroline", "initials": "C", "orcid": "0000-0001-6622-3838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e2fc66fb68748eba5a7f8eb93c5ff3f.json"}}], "type": "journal article", "published": "2022-04-19", "journal": {"title": "Ther Adv Respir Dis", "issn": "1753-4666", "issn-l": null, "volume": "16", "issue": null, "pages": "17534666221091183"}, "abstract": "Severe asthma increases the risk of severe COVID-19 outcomes such as hospitalization and death. However, more studies are needed to understand the association between asthma and severe COVID-19.\r\n\r\nA cohort of 150,430 adult asthma patients were identified in the Swedish National Airway Register (SNAR) from 2013 to December 2020. Data on body mass index, smoking habits, lung function, and asthma control test (ACT) were obtained from SNAR, and uncontrolled asthma was defined as ACT \u2a7d19. Patients with severe COVID-19 were identified following hospitalization or in death certificates based on ICD-10 codes U07.1 and U07.2. The Swedish Prescribed Drug register was used to identify comorbidities and data from Statistics Sweden for educational level. Multivariate logistic regression analyses were used to estimate associations with severe COVID-19.\r\n\r\nSevere COVID-19 was identified in 1067 patients (0.7%). Older age (OR = 1.04, 95% CI = 1.03-1.04), male sex (1.42, 1.25-1.61), overweight (1.56, 1.27-1.91), obesity (2.12, 1.73-2.60), high-dose inhaled corticosteroids in combination with long-acting \u03b2-agonists (1.40, 1.22-1.60), dispensed oral corticosteroids \u2a7e2 (1.48, 1.25-1.75), uncontrolled asthma (1.64, 1.35-2.00), cardiovascular disease (1.20, 1.03-1.40), depression (1.47, 1.28-1.68), and diabetes (1.52, 1.29-1.78) were associated with severe COVID-19, while current smoking was inversely associated (0.63, 0.47-0.85). When comparing patients who died from COVID-19 with those discharged alive from hospital until 31 December 2020, older age, male sex, and current smoking were associated with COVID-19 death.\r\n\r\nPatients with uncontrolled asthma and high disease burden, including increased asthma medication intensity, should be identified as risk patients for severe COVID-19. Furthermore, current smoking is strongly associated with COVID-19 death in asthma.", "doi": "10.1177/17534666221091183", "pmid": "35430944", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pmc", "key": "PMC9019327"}], "notes": [], "created": "2023-01-13T09:54:31.722Z", "modified": "2023-01-13T09:56:02.884Z"}, {"entity": "publication", "iuid": "17d4b6ebe48f4891bf1e5a56692d5e69", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/17d4b6ebe48f4891bf1e5a56692d5e69.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/17d4b6ebe48f4891bf1e5a56692d5e69"}}, "title": "The Evolution of Blood Cell Phenotypes, Intracellular and Plasma Cytokines and Morphological Changes in Critically Ill COVID-19 Patients.", "authors": [{"family": "Bergh\u00e4ll", "given": "Elisabeth", "initials": "E", "orcid": "0000-0002-3287-6504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6aacfcdf39b46daaa541c3123927ab6.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Hahn-Str\u00f6mberg", "given": "Victoria", "initials": "V"}], "type": "journal article", "published": "2022-04-19", "journal": {"title": "Biomedicines", "issn": "2227-9059", "issn-l": null, "volume": "10", "issue": "5", "pages": null}, "abstract": "Severe coronavirus disease 2019 (COVID-19) causes a strong inflammatory response. To obtain an overview of inflammatory mediators and effector cells, we studied 25 intensive-care-unit patients during the timeframe after off-label chloroquine treatment and before an introduction of immunomodulatory drugs.\r\n\r\nBlood samples were weekly examined with flow cytometry (FCM) for surface and intracytoplasmic markers, cytokine assays were analyzed for circulating interleukins (ILs), and blood smears were evaluated for morphological changes. Samples from healthy volunteers were used for comparison. Organ function data and 30-day mortality were obtained from medical records.\r\n\r\nCompared to that of the healthy control group, the expression levels of leukocyte surface markers, i.e., the cluster of differentiation (CD) markers CD2, CD4, CD8, CD158d, CD25, CD127, and CD19, were lower (p &lt; 0.001), while those of leukocytes expressing CD33 were increased (p &lt; 0.05). An aberrant expression of CD158d on granulocytes was found on parts of the granulocyte population. The expression levels of intracellular tumor necrosis factor alpha (TNF\u03b1) and IL-1 receptor type 2 in leukocytes were higher (p &lt; 0.001) as well as plasma levels of TNF\u03b1, IL-2, IL-6, IL-8, IL-10 (p &lt; 0.001), interferon gamma (IFN\u03b3) (p &lt; 0.01), and granulocyte-macrophage colony-stimulating factor (GM-CSF) (p &lt; 0.05). The expression levels of CD33+ leukocytes and circulating IL-6 were higher (p &lt; 0.05) among patients with arterial oxygen partial pressure-to-fractional inspired oxygen (PaO2/FiO2) ratios below 13.3 kPa compared to in the remaining patients. The expression levels of TNF\u03b1, IL-2, IL-4, IL-6, IL-8, and IL-10 were higher in patients treated with continuous renal replacement therapy (CRRT) (p &lt; 0.05), and the levels of the maximum plasma creatinine and TNF\u03b1 Spearman's rank-order correlation coefficient (rho = 0.51, p &lt; 0.05) and IL-8 (rho = 0.44, p &lt; 0.05) correlated. Blood smears revealed neutrophil dysplasia with pseudo-Pelger forms being most common.\r\n\r\nThese findings suggest that patients with severe COVID-19, in addition to augmented ILs, lymphopenia, and increased granulocytes, also had effects on the bone marrow.", "doi": "10.3390/biomedicines10050934", "pmid": "35625671", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "biomedicines10050934"}], "notes": [], "created": "2022-06-21T17:43:10.166Z", "modified": "2022-08-19T12:34:49.174Z"}, {"entity": "publication", "iuid": "811f1f490b264020b8b6e2c851d2ef83", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/811f1f490b264020b8b6e2c851d2ef83.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/811f1f490b264020b8b6e2c851d2ef83"}}, "title": "Dissecting the Molecular Mechanisms Surrounding Post-COVID-19 Syndrome and Neurological Features.", "authors": [{"family": "Mohamed", "given": "Mohamed S", "initials": "MS"}, {"family": "Johansson", "given": "Anton", "initials": "A"}, {"family": "Jonsson", "given": "J\u00f6rgen", "initials": "J"}, {"family": "Schi\u00f6th", "given": "Helgi B", "initials": "HB"}], "type": "journal article", "published": "2022-04-12", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "23", "issue": "8", "issn-l": null}, "abstract": "Many of the survivors of the novel coronavirus disease (COVID-19) are suffering from persistent symptoms, causing significant morbidity and decreasing their quality of life, termed \"post-COVID-19 syndrome\" or \"long COVID\". Understanding the mechanisms surrounding PCS is vital to developing the diagnosis, biomarkers, and possible treatments. Here, we describe the prevalence and manifestations of PCS, and similarities with previous SARS epidemics. Furthermore, we look at the molecular mechanisms behind the neurological features of PCS, where we highlight important neural mechanisms that may potentially be involved and pharmacologically targeted, such as glutamate reuptake in astrocytes, the role of NMDA receptors and transporters (EAAT2), ROS signaling, astrogliosis triggered by NF-\u03baB signaling, KNDy neurons, and hypothalamic networks involving Kiss1 (a ligand for the G-protein-coupled receptor 54 (GPR54)), among others. We highlight the possible role of reactive gliosis following SARS-CoV-2 CNS injury, as well as the potential role of the hypothalamus network in PCS manifestations.", "doi": "10.3390/ijms23084275", "pmid": "35457093", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC9028501"}, {"db": "pii", "key": "ijms23084275"}], "notes": [], "created": "2023-01-13T13:33:37.680Z", "modified": "2023-01-13T13:33:37.694Z"}, {"entity": "publication", "iuid": "55a6ebbc875e40729467c6ea2c76a8a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/55a6ebbc875e40729467c6ea2c76a8a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/55a6ebbc875e40729467c6ea2c76a8a6"}}, "title": "Specific T-cell responses for guiding treatment with convalescent plasma in severe COVID-19 and humoral immunodeficiency: a case report.", "authors": [{"family": "Nystr\u00f6m", "given": "Katarina", "initials": "K"}, {"family": "Hjorth", "given": "Maria", "initials": "M"}, {"family": "Fust", "given": "Ramona", "initials": "R"}, {"family": "Nilsdotter-Augustinsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Larsson", "given": "Marie", "initials": "M"}, {"family": "Niward", "given": "Katarina", "initials": "K"}, {"family": "Nystr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0002-0145-4966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56bc7bc8ab444c81afd336394ae7607d.json"}}], "type": "case reports", "published": "2022-04-11", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "volume": "22", "issue": "1", "pages": "362", "issn-l": null}, "abstract": "The immune response to SARS-CoV-2 virus, the cause of COVID-19, is complex. Antibody mediated responses are important for viral clearance but may also drive hyperinflammation in severe COVID-19. We present a case of an individual with a genetic inability to produce antibodies and severe COVID-19, receiving no other specific anti-viral treatment than convalescent COVID-19 plasma, illustrating that hyperinflammation can occur in the absence of a humoral anti-viral response. In addition, the case illustrates that the assessment of SARS-CoV-2 T cell responses can facilitate clinical decision making in patients with COVID-19 and weak or absent humoral immune responses.\n\nA male with X-linked agammaglobulinemia on regular immunoglobulin replacement therapy, hospitalized for 35 days due to severe COVID-19. Systemic inflammatory parameters were highly elevated. After treatment with convalescent COVID-19 plasma he became afebrile and the fatigue diminished. He was discharged on day 42 and nasopharyngeal SARS-CoV-2 PCR eventually was negative on day 49. Evidence of SARS-CoV-2 specific T cells prior to administration of plasma therapy suggested that antibodies were crucial for viral clearance. Regular assessment showed robust and persistent SARS-CoV-2 specific T-cell responses after recovery suggested that prophylactic administration of convalescent COVID-19 plasma was unnecessary.\n\nAssessment of SARS-CoV-2T-cell responses can facilitate the clinical management of COVID-19 patients with humoral immunodeficiencies.", "doi": "10.1186/s12879-022-07323-4", "pmid": "35410137", "labels": {"Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12879-022-07323-4"}, {"db": "pmc", "key": "PMC8996199"}], "notes": [], "created": "2022-10-13T13:01:08.111Z", "modified": "2022-10-13T13:01:08.145Z"}, {"entity": "publication", "iuid": "ed9f0221711e4437bea0df3752e4e0fe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed9f0221711e4437bea0df3752e4e0fe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed9f0221711e4437bea0df3752e4e0fe"}}, "title": "Impact of covid-19 on long-term oxygen therapy 2020: A nationwide study in Sweden.", "authors": [{"family": "Sundh", "given": "Josefin", "initials": "J", "orcid": "0000-0003-1926-8464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0994c494df3b4955bedb00606add70d6.json"}}, {"family": "Palm", "given": "Andreas", "initials": "A"}, {"family": "Wahlberg", "given": "Josefin", "initials": "J"}, {"family": "Runold", "given": "Michael", "initials": "M"}, {"family": "Ekstr\u00f6m", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2022-04-08", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "4", "pages": "e0266367", "issn-l": "1932-6203"}, "abstract": "Covid-19 can cause chronic hypoxic respiratory failure, but the impact on the need for long-term oxygen therapy (LTOT) is unknown. The aim was to investigate change in incidence and characteristics of patients starting LTOT in Sweden 2020 after the outbreak of the pandemic.\n\nPopulation-based observational study using data from the National Registry for Respiratory Failure (Swedevox) and from a survey to all centres prescribing LTOT in Sweden. Swedevox data provided information on incidence of LTOT and characteristics of patients starting LTOT during 2015-2020.\n\nBetween March-Dec 2020, 131 patients started LTOT due to covid-19, corresponding to 20.5% of incident LTOT in Sweden. Compared with 2015-19, the total number of patients starting LTOT did not increase. No significant differences in patient characteristics or underlying causes of hypoxemia were found between patients starting LTOT during 2020 compared 2015-2019. The majority of the LTOT centres estimated that, since the start of the pandemic, the incidence of LTOT was unchanged and the time devoted for LTOT work was the same or slightly less.\n\nCovid-19 caused one fifth of all LTOT starts during the pandemic in 2020. The LTOT incidence overall did not increase possibly due to reduction in other infections.", "doi": "10.1371/journal.pone.0266367", "pmid": "35395039", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8992997"}, {"db": "pii", "key": "PONE-D-21-37749"}], "notes": [], "created": "2023-01-13T13:41:15.466Z", "modified": "2023-01-13T13:41:15.492Z"}, {"entity": "publication", "iuid": "cc323c7ea5b948ddb0f5c9673daaaa59", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc323c7ea5b948ddb0f5c9673daaaa59.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc323c7ea5b948ddb0f5c9673daaaa59"}}, "title": "An olfactory self-test effectively screens for COVID-19.", "authors": [{"family": "Snitz", "given": "Kobi", "initials": "K"}, {"family": "Honigstein", "given": "Danielle", "initials": "D"}, {"family": "Weissgross", "given": "Reut", "initials": "R", "orcid": "0000-0002-6554-9462", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03bcaa7f65b342719a8e846b28c2b282.json"}}, {"family": "Ravia", "given": "Aharon", "initials": "A", "orcid": "0000-0003-2183-9254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3599c1d815e04e338fe4440fdc95be77.json"}}, {"family": "Mishor", "given": "Eva", "initials": "E", "orcid": "0000-0003-4006-3789", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2ede0162e8d4daf81350bacab4d7f9d.json"}}, {"family": "Perl", "given": "Ofer", "initials": "O"}, {"family": "Karagach", "given": "Shiri", "initials": "S"}, {"family": "Medhanie", "given": "Abebe", "initials": "A"}, {"family": "Harel", "given": "Nir", "initials": "N"}, {"family": "Shushan", "given": "Sagit", "initials": "S"}, {"family": "Roth", "given": "Yehudah", "initials": "Y"}, {"family": "Iravani", "given": "Behzad", "initials": "B", "orcid": "0000-0001-9905-1067", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5c799aeccef49a59531ad96984f466b.json"}}, {"family": "Arshamian", "given": "Artin", "initials": "A"}, {"family": "Ernst", "given": "Gernot", "initials": "G", "orcid": "0000-0001-5224-0338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/afb20633af994b808d8e6818812afa59.json"}}, {"family": "Okamoto", "given": "Masako", "initials": "M"}, {"family": "Poo", "given": "Cindy", "initials": "C"}, {"family": "Bonacchi", "given": "Niccol\u00f2", "initials": "N", "orcid": "0000-0001-5228-6918", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b985fa7a1f24d44bd254daba559c128.json"}}, {"family": "Mainen", "given": "Zachary", "initials": "Z", "orcid": "0000-0001-7913-9109", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a189fcf3c6d41f98339f08ebdf8244a.json"}}, {"family": "Monteleone", "given": "Erminio", "initials": "E"}, {"family": "Dinnella", "given": "Caterina", "initials": "C", "orcid": "0000-0002-5765-6057", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/315a95a9248c43dfb7ed2231824b6ced.json"}}, {"family": "Spinelli", "given": "Sara", "initials": "S"}, {"family": "Mari\u00f1o-S\u00e1nchez", "given": "Franklin", "initials": "F"}, {"family": "Ferdenzi", "given": "Camille", "initials": "C"}, {"family": "Smeets", "given": "Monique", "initials": "M"}, {"family": "Touhara", "given": "Kazushige", "initials": "K"}, {"family": "Bensafi", "given": "Moustafa", "initials": "M", "orcid": "0000-0002-2991-3036", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11b9f8b4dfbd4345ad03a0a694d5efcd.json"}}, {"family": "Hummel", "given": "Thomas", "initials": "T"}, {"family": "Lundstr\u00f6m", "given": "Johan N", "initials": "JN", "orcid": "0000-0002-3529-8981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a92f50aea024a1fbf0cfda979efef11.json"}}, {"family": "Sobel", "given": "Noam", "initials": "N", "orcid": "0000-0002-3232-9391", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34beac29a3ed4d169aa33d270f09d186.json"}}], "type": "journal article", "published": "2022-04-05", "journal": {"title": "Commun Med (Lond)", "issn": "2730-664X", "volume": "2", "pages": "34", "issn-l": null}, "abstract": "Key to curtailing the COVID-19 pandemic are wide-scale screening strategies. An ideal screen is one that would not rely on transporting, distributing, and collecting physical specimens. Given the olfactory impairment associated with COVID-19, we developed a perceptual measure of olfaction that relies on smelling household odorants and rating them online.\n\nEach participant was instructed to select 5 household items, and rate their perceived odor pleasantness and intensity using an online visual analogue scale. We used this data to assign an olfactory perceptual fingerprint, a value that reflects the perceived difference between odorants. We tested the performance of this real-time tool in a total of 13,484 participants (462 COVID-19 positive) from 134 countries who provided 178,820 perceptual ratings of 60 different household odorants.\n\nWe observe that olfactory ratings are indicative of COVID-19 status in a country, significantly correlating with national infection rates over time. More importantly, we observe indicative power at the individual level (79% sensitivity and 87% specificity). Critically, this olfactory screen remains effective in participants with COVID-19 but without symptoms, and in participants with symptoms but without COVID-19.\n\nThe current odorant-based olfactory screen adds a component to online symptom-checkers, to potentially provide an added first line of defense that can help fight disease progression at the population level. The data derived from this tool may allow better understanding of the link between COVID-19 and olfaction.", "doi": "10.1038/s43856-022-00095-7", "pmid": "35603293", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "95"}, {"db": "pmc", "key": "PMC9053292"}], "notes": [], "created": "2022-06-21T17:55:17.396Z", "modified": "2022-11-21T15:30:33.313Z"}, {"entity": "publication", "iuid": "049abad9f8c946609902e95615a648a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/049abad9f8c946609902e95615a648a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/049abad9f8c946609902e95615a648a6"}}, "title": "Impact of post-COVID conditions on mental health: a cross-sectional study in Japan and Sweden.", "authors": [{"family": "Matsumoto", "given": "Kazuki", "initials": "K"}, {"family": "Hamatani", "given": "Sayo", "initials": "S", "orcid": "0000-0001-7847-6381", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ed7722373ad4aed8a58e4ee130a925f.json"}}, {"family": "Shimizu", "given": "Eiji", "initials": "E"}, {"family": "K\u00e4ll", "given": "Anton", "initials": "A"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}], "type": "journal article", "published": "2022-04-04", "journal": {"title": "BMC Psychiatry", "issn": "1471-244X", "volume": "22", "issue": "1", "pages": "237", "issn-l": null}, "abstract": "Due to the coronavirus disease 2019 (COVID-19) pandemic, people have undermined their mental health. It has been reported that post-COVID conditions at a certain rate. However, information on the mental health of people with post-COVID conditions is limited. Thus, this study investigated the relationship between post-COVID conditions and mental health.\n\nDesign of the present study was an International and collaborative cross-sectional study in Japan and Sweden from March 18 to June 15, 2021. The analyzed data included 763 adults who participated in online surveys in Japan and Sweden and submitted complete data. In addition to demographic data including terms related to COVID-19, psychiatric symptoms such as depression, anxiety, and post-traumatic stress were measured by using the fear of COVID-19 scale (FCV-19S), Patient Health Questionnaire-9 (PHQ-9), General Anxiety Disorder-7 item (GAD-7), and Impact of Event Scale-Revised (IES-R).\n\nOf the 135 COVID-19 survivors among the 763 total participants, 37.0% (n = 50/135) had COVID-19-related sequelae. First, the results of the Bonferroni-corrected Mann Whitney U test showed that the group infected SARS-CoV-2 with post-COVID conditions scored significantly higher than those without one and the non-infected group on all clinical symptom scales (P \u2264 .05). Next, there was a significant difference that incidence rates of clinical-significant psychiatric symptoms among each group from the results of the Chi-squared test (P \u2264 .001). Finally, the results of the multivariate logistic model revealed that the risk of having more severe clinical symptoms were 2.44-3.48 times higher among participants with post-COVID conditions.\n\nThe results showed that approximately half had some physical symptoms after COVID-19 and that post-COVID conditions may lead to the onset of mental disorders.\n\nThe ethics committee of Chiba University approved this cross-sectional study (approval number: 4129). However, as no medical intervention was conducted, a clinical trial registration was not necessary.", "doi": "10.1186/s12888-022-03874-7", "pmid": "35379224", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8977559"}, {"db": "pii", "key": "10.1186/s12888-022-03874-7"}], "notes": [], "created": "2023-01-13T13:40:33.923Z", "modified": "2023-01-13T13:40:33.970Z"}, {"entity": "publication", "iuid": "1dd2f6a205d9420394113cfef0c78c22", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1dd2f6a205d9420394113cfef0c78c22.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1dd2f6a205d9420394113cfef0c78c22"}}, "title": "COVID-19 IDD: Findings from a global survey exploring family members' and paid staff's perceptions of the impact of COVID-19 on individuals with intellectual and developmental disabilities (IDD) and their caregivers.", "authors": [{"family": "Linehan", "given": "Christine", "initials": "C", "orcid": "0000-0002-9083-3457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b2eec9989c3470fb49471050007ea84.json"}}, {"family": "Birkbeck", "given": "Gail", "initials": "G"}, {"family": "Araten-Bergman", "given": "Tal", "initials": "T", "orcid": "0000-0003-4915-2729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aaffeee537eb4a27b785d4e4db4134c6.json"}}, {"family": "Baumbusch", "given": "Jennifer", "initials": "J"}, {"family": "Beadle-Brown", "given": "Julie", "initials": "J"}, {"family": "Bigby", "given": "Christine", "initials": "C", "orcid": "0000-0001-7001-8976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb03eecfdf5748ccadd49117bea5b00b.json"}}, {"family": "Bradley", "given": "Valerie", "initials": "V"}, {"family": "Brown", "given": "Michael", "initials": "M", "orcid": "0000-0003-3230-401X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34355c671e7b491cbd5b76429680aad3.json"}}, {"family": "Bredewold", "given": "Femmianne", "initials": "F", "orcid": "0000-0002-6231-8263", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7dca30eb8e3f487fb8f7f1bf67d44ed5.json"}}, {"family": "Chirwa", "given": "Masauso", "initials": "M", "orcid": "0000-0002-6293-5034", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f99b5be63ea94917a122bba4751e0168.json"}}, {"family": "Cui", "given": "Jialiang", "initials": "J", "orcid": "0000-0001-8708-1947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/393d73a952544ea28655eb9073fe42b1.json"}}, {"family": "Godoy Gimenez", "given": "Marta", "initials": "M"}, {"family": "Gomeiro", "given": "Tiziano", "initials": "T", "orcid": "0000-0002-2931-9571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74a9af063b354d07bf09cd1f73dac2de.json"}}, {"family": "Kanova", "given": "\u0160\u00e1rka", "initials": "\u0160", "orcid": "0000-0003-0846-5737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19dc6d08bfa648feba2d4d0fa83b6dca.json"}}, {"family": "Kroll", "given": "Thilo", "initials": "T", "orcid": "0000-0003-2082-5117", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb39d4a6cc8f439581040333ce92d6bb.json"}}, {"family": "Li", "given": "Henan", "initials": "H"}, {"family": "MacLachlan", "given": "Mac", "initials": "M"}, {"family": "Narayan", "given": "Jayanthi", "initials": "J", "orcid": "0000-0001-5125-0227", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58b00b867ac3442d8d9d316d9d2dc036.json"}}, {"family": "Nearchou", "given": "Finiki", "initials": "F", "orcid": "0000-0002-2018-9096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db4b9458035a4304a7e588be8533b39c.json"}}, {"family": "Nolan", "given": "Adam", "initials": "A"}, {"family": "O'Donovan", "given": "Mary-Ann", "initials": "MA", "orcid": "0000-0002-3378-5305", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af60d1c4e1464ffaa3c0499892d9fd0e.json"}}, {"family": "Santos", "given": "Flavia H", "initials": "FH", "orcid": "0000-0003-2592-9038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7e5d5f9645d48fabc19480b9af1d79e.json"}}, {"family": "\u0160i\u0161ka", "given": "Jan", "initials": "J", "orcid": "0000-0003-2379-2285", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5471f9d32d384e13a0fcc75e62df4766.json"}}, {"family": "Stainton", "given": "Tim", "initials": "T", "orcid": "0000-0002-5146-2497", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d297befd524e494f8f100394ab2cd84a.json"}}, {"family": "Tideman", "given": "Magnus", "initials": "M", "orcid": "0000-0002-7519-6488", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96ec2f02bc4b40ddadf2969252205539.json"}}, {"family": "Tossebro", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2022-04-04", "journal": {"title": "HRB Open Res", "issn": "2515-4826", "volume": "5", "pages": "27", "issn-l": null}, "abstract": "Background: A growing body of evidence attests to the disproportionate impact of COVID-19 on persons with intellectual and developmental disabilities (IDD) during the pandemic. This study asked caregivers about their perceptions of how COVID-19 impacted them and the people they support. Method: An online survey was conducted in 12 countries during August-September 2020 and sought information on demographics, support practices, information and training, experiences of COVID-19, social distancing, and wellbeing, as measured by the DASS12. This study reports on 3,754 family members, direct support professionals, and managers who participated in the survey. Results: Caregivers observed increases in depression/anxiety, stereotyped behaviours, aggression towards others and weight gain in the person(s) they supported. They also reported difficulties supporting the person(s) to access healthcare. Families reported reducing or ceasing employment and absorbed additional costs when supporting their family member. Direct support professionals experienced changes in staff shifts, staff absences, increased workload and hiring of casual staff. Caregivers' wellbeing revealed high levels of stress, depression, and less so anxiety. The strongest predictor of wellbeing among families was observation of changes in mood in the person(s) they supported, while for direct support professionals, the strongest predictors of wellbeing were reorganisation of staff shifts and increases in new direct support staff. Discussion: Findings support the contention of this population experiencing a disproportionate burden during the COVID-19 pandemic, reflecting historical inequities in access to healthcare and other human rights violations which are now protected under the United Nations Convention on the Rights of Persons with Disabilities.", "doi": "10.12688/hrbopenres.13497.1", "pmid": "35615436", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9111363"}], "notes": [], "created": "2022-06-21T17:49:34.094Z", "modified": "2022-06-21T17:49:34.715Z"}, {"entity": "publication", "iuid": "bbccc3d17c0f49868fc33a111d36c981", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bbccc3d17c0f49868fc33a111d36c981.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bbccc3d17c0f49868fc33a111d36c981"}}, "title": "Correlates of protection, viral load trajectories and symptoms in BA.1, BA.1.1 and BA.2 breakthrough infections in triple vaccinated healthcare workers", "authors": [{"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Greilert Norin", "given": "Nina", "initials": "N"}, {"family": "Bladh", "given": "Oscar", "initials": "O"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Ng", "given": "Henry", "initials": "H"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "Smed S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-4172-975X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc8af93ec4fa47959515a7b39b10a795.json"}}], "type": "posted-content", "published": "2022-04-03", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.04.02.22273333", "pmid": null, "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2022-10-13T15:17:24.431Z", "modified": "2023-06-19T14:27:45.410Z"}, {"entity": "publication", "iuid": "52c856fe22854e7c81a7c9caff161ffa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/52c856fe22854e7c81a7c9caff161ffa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/52c856fe22854e7c81a7c9caff161ffa"}}, "title": "Angiotensin-converting enzyme 2 and Transmembrane protease serine 2 in female and male patients with end-stage kidney disease.", "authors": [{"family": "Arefin", "given": "Samsul", "initials": "S", "orcid": "0000-0002-8050-9100", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0be84768aaf64d4484f0ba0ea99861d3.json"}}, {"family": "Hernandez", "given": "Leah", "initials": "L"}, {"family": "Ward", "given": "Liam J", "initials": "LJ"}, {"family": "Schwarz", "given": "Angelina", "initials": "A"}, {"family": "Barany", "given": "Peter", "initials": "P"}, {"family": "Stenvinkel", "given": "Peter", "initials": "P"}, {"family": "Kublickiene", "given": "Karolina", "initials": "K"}, {"family": "GOING-FWD Collaborators", "given": "", "initials": ""}], "type": "journal article", "published": "2022-04-02", "journal": {"title": "Eur J Clin Invest", "issn": "1365-2362", "pages": "e13786", "issn-l": null}, "abstract": "Individuals with chronic kidney disease are affected by acute respiratory syndrome coronavirus 2 (SARS-CoV-2) due to multiple comorbidities and altered immune system. The first step of the infection process is the binding of SARS-CoV-2 with angiotensin-converting enzyme 2 (ACE2) receptor, followed by its priming by transmembrane protease serine 2 (TMPRSS2). We hypothesized that circulating soluble ACE2 levels, as well as the expressions of ACE2 and TMPRSS2 in the microvasculature, are increased in patients with end-stage kidney disease (ESKD).\n\nA total of 210 participants were enrolled, representing 80 ESKD patients and 73 non-CKD controls for soluble ACE2, and 31 ESKD and 26 non-CKD controls for vasculature and fat tissue bioassays. We have assessed ACE2 expression in blood using ELISA and in tissue using immunofluorescence.\n\nSoluble ACE2 levels were higher in ESKD patients compared to controls however, there is no sex difference observed. In ESKD and controls, soluble ACE2 positively correlated with IL-6 and hsCRP respectively. Similarly, ACE2 tissue expression in the vasculature was higher in ESKD patients, moreover, this higher ACE2 expression was observed only in male ESKD patients. In addition, TMPRSS2 expression was observed in vessels from males and females but showed no sex difference. The expression of ACE2 receptor was higher in ESKD patients on ACE-inhibitor/angiotensin blocker treatment.\n\nESKD is associated with increased ACE2 levels in the circulation and pronounced in male vasculature, however further studies are warranted to assess possible sex differences on specific treatment regime(s) for different comorbidities present in ESKD.", "doi": "10.1111/eci.13786", "pmid": "35366343", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-04-04T06:22:59.917Z", "modified": "2022-04-04T06:23:32.705Z"}, {"entity": "publication", "iuid": "ce32d7ce04f74c4e8ee3ca08a4e892e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ce32d7ce04f74c4e8ee3ca08a4e892e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ce32d7ce04f74c4e8ee3ca08a4e892e7"}}, "title": "ABO and RhD blood group are not associated with mortality and morbidity in critically ill patients; a multicentre observational study of 29 512 patients.", "authors": [{"family": "Kander", "given": "Thomas", "initials": "T"}, {"family": "Bjurstr\u00f6m", "given": "Martin F", "initials": "MF"}, {"family": "Frigyesi", "given": "Attila", "initials": "A"}, {"family": "J\u00f6ud", "given": "Magnus", "initials": "M"}, {"family": "Nilsson", "given": "Caroline U", "initials": "CU"}], "type": "journal article", "published": "2022-04-02", "journal": {"title": "BMC Anesthesiol", "issn": "1471-2253", "volume": "22", "issue": "1", "pages": "91", "issn-l": null}, "abstract": "The ABO and RhD blood group represent antigens on the surface of erythrocytes. The ABO blood group antigens are also present on multiple other cells. Interestingly, previous studies have demonstrated associations between the blood group and many types of disease. The present study aimed to identifying associations between the ABO blood group, the RhD blood group, and morbidity and mortality in a mixed cohort and in six pre-defined subgroups of critically ill patients.\n\nAdult patients admitted to any of the five intensive care units (ICUs) in the Scania Region, Sweden, between February 2007 and April 2021 were eligible for inclusion. The outcomes were mortality analysed at 28- and 90-days as well as at the end of observation and morbidity measured using days alive and free of (DAF) invasive ventilation (DAF ventilation) and DAF circulatory support, including vasopressors or inotropes (DAF circulation), maximum Sequential Organ Failure Assessment score (SOFAmax) the first 28 days after admission and length of stay. All outcomes were analysed in separate multivariable regression models adjusted for age and sex. In addition, in a sensitivity analysis, five subgroups of patients with the main diagnoses sepsis, septic shock, acute respiratory distress syndrome, cardiac arrest and trauma were analysed using the same separate multivariable regression models.\n\nIn total, 29,512 unique patients were included in the analyses. There were no significant differences for any of the outcomes between non-O blood groups and blood group O, or between RhD blood groups. In the sensitivity analysis of subgroups, there were no differences in mortality between non-O blood groups and blood group O or between the RhD blood groups. AB was the most common blood group in the COVID-19 cohort.\n\nThe ABO and RhD blood group do not influence mortality or morbidity in a general critically ill patient population.", "doi": "10.1186/s12871-022-01626-4", "pmid": "35366803", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12871-022-01626-4"}], "notes": [], "created": "2022-04-04T06:22:38.196Z", "modified": "2022-04-04T06:22:38.231Z"}, {"entity": "publication", "iuid": "dbd6140519994f4bad11d82be6f43d99", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dbd6140519994f4bad11d82be6f43d99.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dbd6140519994f4bad11d82be6f43d99"}}, "title": "VCA in the Era of the COVID-19 Pandemic.", "authors": [{"family": "Petruzzo", "given": "Palmina", "initials": "P"}, {"family": "Kanitakis", "given": "Jean", "initials": "J"}, {"family": "Sardu", "given": "Claudia", "initials": "C"}, {"family": "Bassiri Gharb", "given": "Bahar", "initials": "B"}, {"family": "Morelon", "given": "Emmanuel", "initials": "E"}, {"family": "Amer", "given": "Hatem", "initials": "H"}, {"family": "Barret", "given": "Juan", "initials": "J"}, {"family": "Burt", "given": "James", "initials": "J"}, {"family": "Brandacher", "given": "Gerald", "initials": "G"}, {"family": "Gomez", "given": "Tomas", "initials": "T"}, {"family": "Kay", "given": "Simon", "initials": "S"}, {"family": "Kaminska", "given": "Dorotha", "initials": "D"}, {"family": "Kaufman", "given": "Christina L", "initials": "CL"}, {"family": "Kumar", "given": "Dinesh S", "initials": "DS"}, {"family": "Iglesias", "given": "Martin", "initials": "M"}, {"family": "Iyer", "given": "Subramania", "initials": "S"}, {"family": "Landin", "given": "Luis", "initials": "L"}, {"family": "Lanzetta", "given": "Marco", "initials": "M"}, {"family": "Lassus", "given": "Patrick", "initials": "P"}, {"family": "Levin", "given": "Scott", "initials": "S"}, {"family": "Papay", "given": "Francis", "initials": "F"}, {"family": "Pomahac", "given": "Bohdan", "initials": "B"}, {"family": "Sassu", "given": "Paolo", "initials": "P"}, {"family": "Satbhai", "given": "Nilesh G", "initials": "NG"}, {"family": "Talbot", "given": "Simon", "initials": "S"}, {"family": "VCA-COVID Survey Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-04-01", "journal": {"title": "Transplantation", "issn": "1534-6080", "volume": "106", "issue": "4", "pages": "690-692", "issn-l": null}, "abstract": null, "doi": "10.1097/TP.0000000000004041", "pmid": "35333847", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "00007890-202204000-00005"}, {"db": "pmc", "key": "PMC8942593"}], "notes": [], "created": "2022-04-04T06:56:37.125Z", "modified": "2022-04-04T06:56:50.268Z"}, {"entity": "publication", "iuid": "96e41f1753ce4163b558b31d1be31822", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/96e41f1753ce4163b558b31d1be31822.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/96e41f1753ce4163b558b31d1be31822"}}, "title": "Public risk perception and behaviours towards COVID-19 during the first and second waves in Nigeria: a secondary data analysis.", "authors": [{"family": "Ochu", "given": "Chinwe Lucia", "initials": "CL", "orcid": "0000-0002-0630-7332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f390fa99a654ff899f5e9df6fbaf88e.json"}}, {"family": "Onoja", "given": "Michael", "initials": "M"}, {"family": "Olatunji", "given": "David", "initials": "D"}, {"family": "Okusanya", "given": "Babasola O", "initials": "BO"}, {"family": "Usuwa", "given": "Ifeoma Sophia", "initials": "IS", "orcid": "0000-0002-9584-784X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/faff911036d446d2aa187ecb925dbce7.json"}}, {"family": "Akeju", "given": "David O", "initials": "DO"}, {"family": "Disu", "given": "Yahya", "initials": "Y"}, {"family": "Adejo", "given": "Samuel Ojima", "initials": "SO"}, {"family": "Eziechina", "given": "Sunday", "initials": "S"}, {"family": "Nwiyi", "given": "Gloria", "initials": "G"}, {"family": "Okediran", "given": "James Olatunde", "initials": "JO"}, {"family": "Elimian", "given": "Kelly Osezele", "initials": "KO", "orcid": "0000-0003-2729-1613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/695dddf720414c3585d35b30184f0178.json"}}, {"family": "Akande", "given": "Oluwatosin Wuraola", "initials": "OW"}, {"family": "Dunkwu", "given": "Lauryn", "initials": "L"}, {"family": "Fagbemi", "given": "Babafunke", "initials": "B"}, {"family": "Aisiri", "given": "Adolor", "initials": "A"}, {"family": "Agogo", "given": "Emmanuel A", "initials": "EA"}, {"family": "Ebenso", "given": "Bassey", "initials": "B", "orcid": "0000-0003-4147-0968", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40b960008ed04f54adb2d62d088232ee.json"}}, {"family": "Oke", "given": "David Adewale", "initials": "DA"}, {"family": "Igumbor", "given": "Ehimario", "initials": "E"}, {"family": "Ihekweazu", "given": "Chikwe", "initials": "C"}], "type": "journal article", "published": "2022-04-01", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "4", "pages": "e058747", "issn-l": "2044-6055"}, "abstract": "To describe changes in public risk perception and risky behaviours during the first wave (W1) and second wave (W2) of COVID-19 in Nigeria, associated factors and observed trend of the outbreak.\n\nA secondary data analysis of cross-sectional telephone-based surveys conducted during the W1 and W2 of COVID-19 in Nigeria.\n\nNigeria.\n\nData from participants randomly selected from all states in Nigeria.\n\nRisk perception for COVID-19 infection categorised as risk perceived and risk not perceived.\n\nCompliance to public health and social measures (PHSMs) categorised as compliant; non-compliant and indifferent.\n\nComparison of frequencies during both waves using \u03c72 statistic to test for associations. Univariate and multivariate logistic regression analyses helped estimate the unadjusted and adjusted odds of risk perception of oneself contracting COVID-19. Level of statistical significance was set at p<0.05.\n\nTriangulated datasets had a total of 6401 respondents, majority (49.5%) aged 25-35 years. Overall, 55.4% and 56.1% perceived themselves to be at risk of COVID-19 infection during the W1 and W2, respectively. A higher proportion of males than females perceived themselves to be at risk during the W1 (60.3% vs 50.3%, p<0.001) and the W2 (58.3% vs 52.6%, p<0.05). Residing in the south-west was associated with not perceiving oneself at risk of COVID-19 infection (W1-AOdds Ratio (AOR) 0.28; 95% CI 0.20 to 0.40; W2-AOR 0.71; 95% CI 0.52 to 0.97). There was significant increase in non-compliance to PHSMs in the W2 compared with W1. Non-compliance rate was higher among individuals who perceived themselves not to be at risk of getting infected (p<0.001).\n\nRisk communication and community engagement geared towards increasing risk perception of COVID-19 should be implemented, particularly among the identified population groups. This could increase adherence to PHSMs and potentially reduce the burden of COVID-19 in Nigeria.", "doi": "10.1136/bmjopen-2021-058747", "pmid": "35365542", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-058747"}], "notes": [], "created": "2022-04-04T06:23:51.989Z", "modified": "2022-04-04T06:24:14.801Z"}, {"entity": "publication", "iuid": "c14bd0e3ce4b4000bd392cb482fb2de7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c14bd0e3ce4b4000bd392cb482fb2de7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c14bd0e3ce4b4000bd392cb482fb2de7"}}, "title": "Factors associated with physical activity reduction in Swedish older adults during the first COVID-19 outbreak: a longitudinal population-based study.", "authors": [{"family": "Sj\u00f6berg", "given": "Linnea", "initials": "L", "orcid": "0000-0002-1621-1174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20688dd7e9de43798d5261b9f1e227cf.json"}}, {"family": "Triolo", "given": "Federico", "initials": "F"}, {"family": "Saadeh", "given": "Marguerita", "initials": "M"}, {"family": "Dekhtyar", "given": "Serhiy", "initials": "S"}, {"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A"}, {"family": "Welmer", "given": "Anna-Karin", "initials": "AK"}], "type": "journal article", "published": "2022-04-01", "journal": {"title": "Eur Rev Aging Phys Act", "issn": "1813-7253", "volume": "19", "issue": "1", "pages": "9", "issn-l": null}, "abstract": "Physical activity (PA) decreased during the COVID-19 pandemic, especially among older adults, potentially leading to adverse consequences for their health. However, factors associated with reductions of PA during the pandemic have not been examined in a population-based sample of older adults. Thus, the aim of this study was to explore the association of pre-pandemic physical, mental, social and lifestyle factors with reductions in PA in older adults during the first wave of COVID-19, and whether the associations differed by age and sex.\n\nA population-based sample of 624 participants aged 65-99 years were identified from the Swedish National study on Aging and Care in Kungsholmen (SNAC-K) COVID19 Study. Information on pre-pandemic factors was collected through clinical examinations, interviews, and self-administered questionnaires in 2016-2019. Changes in light and intense PA during the first wave of the pandemic (May-September 2020) were self-reported. Data were analyzed using multiple logistic regression models, stratified by age (<70 vs. >80 years) and sex.\n\nThere was an association between pre-pandemic levels of higher depressive symptom burden (Odds Ratio (OR): 2.6, 95% Confidence Interval (CI): 1.1-6.4, <70 years), and impaired balance (OR: 1.7, 95% CI: 1.0-2.8, >80 years old) with reductions in light-intensity PA. Furthermore, the presence of musculoskeletal disease (OR: 1.8, 95% CI: 1.1-2.9, <70 years; OR: 2.3, 95% CI: 1.2-4.4, men), moderate/high levels of neuroticism (OR: 1.6, 95% CI: 1.0-2.6, <70 years; OR: 2.2, 95% CI: 1.3-3.5, women), and poor levels of social support (OR: 2.2, 95% CI: 1.2-4.3, >80 years) were related to reductions in higher-intensity PA. Those who were current smokers (OR: 0.3, 95% CI: 0.1-0.8, <70 years; OR: 0.2, 95% CI: 0.06-0.7, women), or had impaired balance (OR: 0.4, 95% CI: 0.2-0.8, >80 years) were less likely to reduce their levels of higher-intensity PA.\n\nFor future pandemics or waves of COVID-19, development of strategies is warranted for older individuals with psychiatric- or physical illness/dysfunction, as well as those with poor social support to counteract reductions in physical activities.", "doi": "10.1186/s11556-022-00287-z", "pmid": "35365065", "labels": {"Type: Journal article": null, "Topics: Register-based research": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s11556-022-00287-z"}], "notes": [], "created": "2022-04-04T06:24:35.714Z", "modified": "2022-04-04T06:24:35.794Z"}, {"entity": "publication", "iuid": "e145bce692554da09fd3e92b3da5536e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e145bce692554da09fd3e92b3da5536e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e145bce692554da09fd3e92b3da5536e"}}, "title": "Facilitators and barriers for effective staff work in Swedish National governmental crisis response to the COVID-19 pandemic.", "authors": [{"family": "Westman", "given": "Anja", "initials": "A", "orcid": "0000-0002-2794-5026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8650cc30d2a14d79aa16b2e4a3024fe2.json"}}, {"family": "Hugelius", "given": "Karin", "initials": "K", "orcid": "0000-0003-0534-4593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f7d4e9ff0f645598a2473e42806066a.json"}}, {"family": "Weinstein", "given": "Eric", "initials": "E", "orcid": "0000-0002-1147-5656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e061be2d669425e9d462d75d69832ad.json"}}, {"family": "Kurland", "given": "Lisa", "initials": "L"}], "type": "journal article", "published": "2022-04-01", "journal": {"title": "Disaster Med Public Health Prep", "issn": "1938-744X", "pages": "1-16", "issn-l": "1935-7893"}, "abstract": "The COVID-19 crisis response in Sweden was managed foremost by a collaboration of several national agencies. Normally their strategical and operational collaboration is limited, but the pandemic required new and unfamiliar collaborations.\n\nThis study aimed to clarify the facilitators and barriers of perceived effective staff work within and between four national agencies.\n\nA qualitative study of 10 participants with leading roles within the four national agencies' crisis organization, recruited via snowball sampling. The interviews were conducted between August - November 2020 and analyzed using content analysis.\n\nFour categories emerged from the analysis: individual characteristics; intra-agency organization; interorganizational collaboration and governmental directives. Subcategories crystalized from the data were analyzed and divided into factors facilitating or to function as barriers for effective staff work.\n\nIndividual factors such as attitude and approach were important for perceived effective staff work as well as clear mandates and structure of the organization. Barriers for perceived effective staff work includes lack of network, the complexity of the mission and organizational structures as well as lack of preparations and unclear mandates. Although flexibility and adaptability are necessary, they cannot always be planned, but be incorporated indirectly by selecting suitable individuals and optimizing organizational planning.", "doi": "10.1017/dmp.2022.91", "pmid": "35362402", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S193578932200091X"}], "notes": [], "created": "2022-04-04T06:32:24.772Z", "modified": "2022-04-04T06:32:24.868Z"}, {"entity": "publication", "iuid": "9cda8b3c808c40ca99fdaa75eafc009e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9cda8b3c808c40ca99fdaa75eafc009e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9cda8b3c808c40ca99fdaa75eafc009e"}}, "title": "Colon cancer treatment in Sweden during the COVID-19 pandemic: a nationwide register-based study.", "authors": [{"family": "Ekl\u00f6v", "given": "Karolina", "initials": "K", "orcid": "0000-0001-5059-5856", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49b27fb96266496d8561f6c0869da3f6.json"}}, {"family": "Nygren", "given": "Jonas", "initials": "J"}, {"family": "Bringman", "given": "Sven", "initials": "S"}, {"family": "L\u00f6fgren", "given": "Jenny", "initials": "J"}, {"family": "Sj\u00f6vall", "given": "Annika", "initials": "A"}, {"family": "Nordenvall", "given": "Caroline", "initials": "C"}, {"family": "Everhov", "given": "\u00c5sa H", "initials": "\u00c5H"}], "type": "journal article", "published": "2022-04-01", "journal": {"title": "Colorectal Dis", "issn": "1463-1318", "issn-l": null}, "abstract": "The COVID-19 pandemic has reduced the capacity to diagnose and treat cancer worldwide due to the prioritization of COVID-19 treatment.\n\nTo investigate treatment and outcomes of colon cancer in Sweden before and during the COVID-19 pandemic.\n\nIn an observational study, using the Swedish Colorectal Cancer Registry, we included (i) all Swedish patients diagnosed with colon cancer, and (ii) all patients undergoing surgery for colon cancer, in 2016-2020. Incidence of colon cancer, treatments and outcomes in 2020 were compared with 2019.\n\nThe number of colon cancer cases in Sweden in April-May 2020 was 27% lower than the previous year, whereas no difference was observed on an annual level (4589 vs 4763 patients (-4%)). Among patients with colon cancer undergoing surgery in 2020, the proportion resections was 93% vs 94% in 2019, with no increase in acute resections. Time from diagnosis to elective surgery decreased (29 days vs 33 days in 2020 vs 2019). In 2020, more patients underwent a 2-stage procedure with a diverting stoma as first surgery (6.1%) vs (4.4%) in 2019 (p=0.0020) and more patients were treated with preoperative chemotherapy (5.1%) vs (3,5%) 2019 (p= 0.0016). The proportion of patients that underwent laparoscopic surgery increased from 54% to 58% (p=0.0017) There were no differences in length of stay, surgical complications, reoperation, ICU-stay or 30-day mortality between the years.\n\nBased on nationwide annual data, we did not observe adverse effects of the COVID-19 pandemic on colon cancer treatment and short time outcomes in Sweden.", "doi": "10.1111/codi.16129", "pmid": "35362199", "labels": {"Category: Health": null, "Type: Journal article": null, "Topics: Register-based research": null}, "xrefs": [], "notes": [], "created": "2022-04-04T06:32:46.143Z", "modified": "2022-04-04T06:32:46.195Z"}, {"entity": "publication", "iuid": "5fec314aa8ce47189a0984489f9241b5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5fec314aa8ce47189a0984489f9241b5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5fec314aa8ce47189a0984489f9241b5"}}, "title": "The social patterning of Covid-19 vaccine uptake in older adults: A register-based cross-sectional study in Sweden.", "authors": [{"family": "Spetz", "given": "Malin", "initials": "M"}, {"family": "Lundberg", "given": "Lisa", "initials": "L"}, {"family": "Nwaru", "given": "Chioma", "initials": "C"}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Hammar", "given": "Niklas", "initials": "N"}, {"family": "Rosvall", "given": "Maria", "initials": "M"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "15", "pages": "100331", "issn-l": null}, "abstract": "A broad vaccination coverage is crucial for preventing the spread of Covid-19 and reduce serious illness or death. The aim of this study was to examine social inequalities in Covid-19 vaccination uptake as of 17th May 2021 among Swedish adults aged \u2265 60 years.\n\nThe study population comprised a general population cohort aged 60 years or older (n = 350,805), representative of the Swedish population. Data were collected through the nationwide linked multi-register observational study SCIFI-PEARL, and associations between sociodemographic determinants and Covid-19 vaccination uptake were analysed using logistic regression. Intersectional analyses of sociodemographic heterogeneity were performed by taking several overlapping social dimensions into account. Data availability extended to 17 May 2021.\n\nThe overall vaccination coverage was 87\u00b72% by 17th May 2021. Younger age, male sex, lower income, living alone, and being born outside Sweden, were all associated with a lower uptake of vaccination. The lowest Covid-19 vaccination uptake was seen in individuals born in low-or middle-income countries, of which only 60% had received vaccination, with an odds ratio (OR) of not being vaccinated of 6\u00b705 (95% CI: 5\u00b785-6\u00b726) compared to individuals born in Sweden. These associations persisted after adjustments for possible confounding factors. The intersectional analyses showed even larger variations in vaccination in cross-classified sociodemographic subgroups (ranging from 44% to 97%) with marked differences in uptake of vaccination within sociodemographic groups.\n\nThe uptake of Covid-19 vaccine during the spring of 2021 in Sweden varied substantially both between and within sociodemographic groups. The use of an intersectional approach, taking several overlapping social dimensions into account at the same time rather than only using one-dimensional measures, contributes to a better understanding of the complexity in the uptake of vaccination.\n\nSciLifeLab / Knut & Alice Wallenberg Foundation, Swedish Research Council, Swedish government ALF-agreement, FORMAS.", "doi": "10.1016/j.lanepe.2022.100331", "pmid": "35252941", "labels": {"Research Area: Vaccine": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Health": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC8881226"}, {"db": "pii", "key": "S2666-7762(22)00024-2"}], "notes": [], "created": "2022-11-29T14:27:55.286Z", "modified": "2022-11-29T14:27:55.300Z"}, {"entity": "publication", "iuid": "ed71d308d25d45d4a52a25812056550f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed71d308d25d45d4a52a25812056550f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed71d308d25d45d4a52a25812056550f"}}, "title": "The effect of the COVID-19 pandemic on severe asthma care in Europe: will care change for good?", "authors": [{"family": "Eger", "given": "Katrien", "initials": "K", "orcid": "0000-0002-9628-2174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ec87651e0164ace9872a7186867fa83.json"}}, {"family": "Paroczai", "given": "Dora", "initials": "D"}, {"family": "Bacon", "given": "Alison", "initials": "A", "orcid": "0000-0003-4279-3814", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b6040010eb24885832dc5ed684e7cfc.json"}}, {"family": "Schleich", "given": "Florence", "initials": "F"}, {"family": "Sergejeva", "given": "Svetlana", "initials": "S"}, {"family": "Bourdin", "given": "Arnaud", "initials": "A", "orcid": "0000-0002-4645-5209", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f88bf68759c246f3a1a7df2749bf606c.json"}}, {"family": "Vachier", "given": "Isabelle", "initials": "I"}, {"family": "Zervas", "given": "Eleftherios", "initials": "E", "orcid": "0000-0001-7436-4550", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0d338ea2b724ccab920b95ae3c42ffe.json"}}, {"family": "Katsoulis", "given": "Konstantinos", "initials": "K"}, {"family": "Papapetrou", "given": "Dimosthenis", "initials": "D"}, {"family": "Kostikas", "given": "Konstantinos", "initials": "K", "orcid": "0000-0003-0774-3942", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3eaa831d14b14f5e9188d8f05ede185f.json"}}, {"family": "Csoma", "given": "Zsuzsanna", "initials": "Z"}, {"family": "Heffler", "given": "Enrico", "initials": "E"}, {"family": "Canonica", "given": "Giorgio Walter", "initials": "GW", "orcid": "0000-0001-8467-2557", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ccaf06bd57b438fabe0a7c904259881.json"}}, {"family": "Grisle", "given": "Ineta", "initials": "I"}, {"family": "Bieksiene", "given": "Kristina", "initials": "K"}, {"family": "Palacionyte", "given": "Jolita", "initials": "J"}, {"family": "Ten Brinke", "given": "Anneke", "initials": "A"}, {"family": "Hashimoto", "given": "Simone", "initials": "S", "orcid": "0000-0001-8995-3817", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5d3f0acc6674d52bd765e2c0e58f4e1.json"}}, {"family": "Smeenk", "given": "Frank W J M", "initials": "FWJM"}, {"family": "Braunstahl", "given": "Gert-Jan", "initials": "GJ", "orcid": "0000-0001-7671-3742", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/129b78ac29b44216a8f4267281441349.json"}}, {"family": "van der Sar", "given": "Simone", "initials": "S"}, {"family": "Mih\u0103l\u0163an", "given": "Florin", "initials": "F"}, {"family": "Nenasheva", "given": "Natalia", "initials": "N"}, {"family": "Peredelskaya", "given": "Marina", "initials": "M"}, {"family": "Zvezdin", "given": "Biljana", "initials": "B"}, {"family": "\u010cekerevac", "given": "Ivan", "initials": "I"}, {"family": "Hromi\u0161", "given": "Sanja", "initials": "S"}, {"family": "\u0106upurdija", "given": "Vojislav", "initials": "V"}, {"family": "Lazic", "given": "Zorica", "initials": "Z"}, {"family": "Milenkovic", "given": "Branislava", "initials": "B"}, {"family": "Dimic-Janjic", "given": "Sanja", "initials": "S"}, {"family": "Yasinska", "given": "Valentyna", "initials": "V"}, {"family": "Dahl\u00e9n", "given": "Barbro", "initials": "B"}, {"family": "Bossios", "given": "Apostolos", "initials": "A", "orcid": "0000-0002-0494-2690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/494bc3af38b0417186d9444f1ee3fa97.json"}}, {"family": "Lazarinis", "given": "Nikolaos", "initials": "N"}, {"family": "Aronsson", "given": "David", "initials": "D"}, {"family": "Egesten", "given": "Arne", "initials": "A"}, {"family": "Munir", "given": "Abul Kashem Mohammad", "initials": "AKM"}, {"family": "Ahlbeck", "given": "Lars", "initials": "L"}, {"family": "Janson", "given": "Christer", "initials": "C", "orcid": "0000-0001-5093-6980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba296cda8ef74430ad5457e71b7dae94.json"}}, {"family": "\u0160krgat", "given": "Sabina", "initials": "S"}, {"family": "Edelbaher", "given": "Natalija", "initials": "N"}, {"family": "Leuppi", "given": "Joerg", "initials": "J"}, {"family": "Jaun", "given": "Fabienne", "initials": "F"}, {"family": "R\u00fcdiger", "given": "Jochen", "initials": "J"}, {"family": "Pavlov", "given": "Nikolay", "initials": "N"}, {"family": "Gianella", "given": "Pietro", "initials": "P"}, {"family": "Fischer", "given": "Reta", "initials": "R"}, {"family": "Charbonnier", "given": "Florian", "initials": "F"}, {"family": "Chaudhuri", "given": "Rekha", "initials": "R"}, {"family": "Smith", "given": "Steven James", "initials": "SJ"}, {"family": "Doe", "given": "Simon", "initials": "S"}, {"family": "Fawdon", "given": "Michelle", "initials": "M"}, {"family": "Masoli", "given": "Matthew", "initials": "M", "orcid": "0000-0003-0909-0148", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83de342198de485ea699edc035980c3c.json"}}, {"family": "Heaney", "given": "Liam", "initials": "L"}, {"family": "Haitchi", "given": "Hans Michael", "initials": "HM", "orcid": "0000-0001-8603-302X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6de760fa29414bf399a0a03e50ddc057.json"}}, {"family": "Kurukulaaratchy", "given": "Ramesh", "initials": "R"}, {"family": "Fulton", "given": "Olivia", "initials": "O", "orcid": "0000-0001-7358-0219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/707e706c3f8149e4aa9a8009017d0028.json"}}, {"family": "Frankem\u00f6lle", "given": "Betty", "initials": "B"}, {"family": "Gibson", "given": "Toni", "initials": "T", "orcid": "0000-0001-8684-8624", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e804ad5e718648acaddacf249d414ae2.json"}}, {"family": "Needham", "given": "Karen", "initials": "K"}, {"family": "Howarth", "given": "Peter", "initials": "P", "orcid": "0000-0003-0619-7927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ac4536cccd642efa26db94364dceac2.json"}}, {"family": "Djukanovic", "given": "Ratko", "initials": "R"}, {"family": "Bel", "given": "Elisabeth", "initials": "E"}, {"family": "Hyland", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "ERJ Open Res", "issn": "2312-0541", "volume": "8", "issue": "2", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has put pressure on healthcare services, forcing the reorganisation of traditional care pathways. We investigated how physicians taking care of severe asthma patients in Europe reorganised care, and how these changes affected patient satisfaction, asthma control and future care.\n\nIn this European-wide cross-sectional study, patient surveys were sent to patients with a physician-diagnosis of severe asthma, and physician surveys to severe asthma specialists between November 2020 and May 2021.\n\n1101 patients and 268 physicians from 16 European countries contributed to the study. Common physician-reported changes in severe asthma care included use of video/phone consultations (46%), reduced availability of physicians (43%) and change to home-administered biologics (38%). Change to phone/video consultations was reported in 45% of patients, of whom 79% were satisfied or very satisfied with this change. Of 709 patients on biologics, 24% experienced changes in biologic care, of whom 92% were changed to home-administered biologics and of these 62% were satisfied or very satisfied with this change. Only 2% reported worsening asthma symptoms associated with changes in biologic care. Many physicians expect continued implementation of video/phone consultations (41%) and home administration of biologics (52%).\n\nChange to video/phone consultations and home administration of biologics was common in severe asthma care during the COVID-19 pandemic and was associated with high satisfaction levels in most but not all cases. Many physicians expect these changes to continue in future severe asthma care, though satisfaction levels may change after the pandemic.", "doi": "10.1183/23120541.00065-2022", "pmid": "35582679", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00065-2022"}, {"db": "pmc", "key": "PMC8994963"}], "notes": [], "created": "2022-06-21T18:03:14.205Z", "modified": "2022-06-21T18:03:33.900Z"}, {"entity": "publication", "iuid": "b9884b197f3146b0aabf7d635fbd8ab2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9884b197f3146b0aabf7d635fbd8ab2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9884b197f3146b0aabf7d635fbd8ab2"}}, "title": "Short-term rental market crisis management during the COVID-19 pandemic: Stakeholders' perspectives.", "authors": [{"family": "Miguel", "given": "Cristina", "initials": "C"}, {"family": "Pechurina", "given": "Anna", "initials": "A"}, {"family": "Kirkulak-Uludag", "given": "Berna", "initials": "B"}, {"family": "Drotarova", "given": "Maria Hadjielia", "initials": "MH"}, {"family": "Duman\u010di\u0107", "given": "Kosjenka", "initials": "K"}, {"family": "Braje", "given": "Ivana Na\u010dinovi\u0107", "initials": "IN"}, {"family": "Giglio", "given": "Carlo", "initials": "C"}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Int J Hosp Manag", "issn": "0278-4319", "issn-l": null, "volume": "102", "issue": null, "pages": "103147"}, "abstract": "Contingency plans and crisis management strategies have been implemented by the short-term rental industry to deal with the COVID-19 pandemic. This paper examines the strategies adopted by three key groups of stakeholders: short-term rental platforms (e.g. Airbnb, Booking.com), service providers (represented by property management companies and short-term rental associations) and policymakers/tourism experts. The professional service providers, in particular, constitute a significant share of the short-term rental industry, but have not received much scholarly attention. In this respect, our study fills this gap by bringing attention to unexplored segments of the short-term rental industry. By examining and comparing the responses from these key groups, the paper contributes to the ongoing research about the workings of the short-term rental industry and its responses to the COVID-19 crisis.", "doi": "10.1016/j.ijhm.2022.103147", "pmid": "35035022", "labels": {"Topics: Register-based research": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0278-4319(22)00009-3"}, {"db": "pmc", "key": "PMC8752289"}], "notes": [], "created": "2022-01-27T07:40:12.388Z", "modified": "2022-11-22T05:38:29.271Z"}, {"entity": "publication", "iuid": "98335ad0296a4ef6a2c0ac2bebc0ae7b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/98335ad0296a4ef6a2c0ac2bebc0ae7b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/98335ad0296a4ef6a2c0ac2bebc0ae7b"}}, "title": "Prevention of Recurrent Childhood Caries with Probiotic Supplements: A Randomized Controlled Trial with a 12-Month Follow-Up.", "authors": [{"family": "Hassl\u00f6f", "given": "P", "initials": "P", "orcid": "0000-0002-7670-3103", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41a254437667432fb88ce0f53d350059.json"}}, {"family": "Granqvist", "given": "L", "initials": "L"}, {"family": "Stecks\u00e9n-Blicks", "given": "C", "initials": "C"}, {"family": "Twetman", "given": "S", "initials": "S"}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Probiotics Antimicrob Proteins", "issn": "1867-1314", "volume": "14", "issue": "2", "pages": "384-390", "issn-l": null}, "abstract": "The aim of this study was to evaluate the effect of drops containing probiotic bacteria on the recurrence of dental caries in preschool children. The study employed a randomized, placebo-controlled, double-blinded design with two parallel arms. 38 preschool children were enrolled after comprehensive restorative treatment under general anesthesia or conscious sedation (baseline), and they were followed up after 6 and 12 months. Parents of children in the test group were instructed to give 5 daily drops containing two strains of Limosilactobacillus reuteri (DSM 17938 and ATCC PTA 5289) at bedtime. The placebo drops were identically composed but lacked bacteria. The duration of the intervention was 12 months. The primary endpoint was recurrence of new caries lesions on subject level (yes/no), and secondary endpoints were presence of dental plaque and gingivitis. We found high rate of recurrent moderate and extensive lesions after 12 months (67%) but there were no significant differences between the groups. We observed no beneficial effects on dental plaque or gingival inflammation. The findings were however uncertain and inconclusive due to lack of power, a consequence of the COVID-19 pandemic. ClinTrials.gov Identifier: (NCT04929340), June 18, 2021; retrospectively registered.", "doi": "10.1007/s12602-022-09913-9", "pmid": "35083729", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s12602-022-09913-9"}, {"db": "pmc", "key": "PMC8791080"}, {"db": "ClinicalTrials.gov", "key": "NCT04929340"}], "notes": [], "created": "2022-01-31T11:47:22.815Z", "modified": "2022-06-21T18:22:19.051Z"}, {"entity": "publication", "iuid": "9c92fc99dc4e4140973b314269871fb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9c92fc99dc4e4140973b314269871fb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9c92fc99dc4e4140973b314269871fb1"}}, "title": "Preterm birth after the introduction of COVID-19 mitigation measures in Norway, Sweden, and Denmark: a registry-based difference-in-differences study.", "authors": [{"family": "Oakley", "given": "Laura L", "initials": "LL"}, {"family": "\u00d6rtqvist", "given": "Anne K", "initials": "AK"}, {"family": "Kinge", "given": "Jonas", "initials": "J"}, {"family": "Hansen", "given": "Anne Vinkel", "initials": "AV"}, {"family": "Petersen", "given": "Tanja Gram", "initials": "TG"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Telle", "given": "Kjetil E", "initials": "KE"}, {"family": "Magnus", "given": "Maria C", "initials": "MC"}, {"family": "Mortensen", "given": "Laust Hvas", "initials": "LH"}, {"family": "Nybo Andersen", "given": "Anne-Marie", "initials": "AM"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Am J Obstet Gynecol", "issn": "1097-6868", "volume": "226", "issue": "4", "pages": "550.e1-550.e22", "issn-l": null}, "abstract": "Although some studies have reported a decrease in preterm birth following the start of the COVID-19 pandemic, the findings are inconsistent.\n\nThis study aimed to compare the incidences of preterm birth before and after the introduction of COVID-19 mitigation measures in Scandinavian countries using robust population-based registry data.\n\nThis was a registry-based difference-in-differences study using births from January 2014 through December 2020 in Norway, Sweden, and Denmark. The changes in the preterm birth (<37 weeks) rates before and after the introduction of COVID-19 mitigation measures (set to March 12, 2020) were compared with the changes in preterm birth before and after March 12 from 2014 to 2019. The differences per 1000 births were calculated for 2-, 4-, 8-, 12-, and 16-week intervals before and after March 12. The secondary analyses included medically indicated preterm birth, spontaneous preterm birth, and very preterm (<32 weeks) birth.\n\nA total of 1,519,521 births were included in this study. During the study period, 5.6% of the births were preterm in Norway and Sweden, and 5.7% were preterm in Denmark. There was a seasonal variation in the incidence of preterm birth, with the highest incidence during winter. In all the 3 countries, there was a slight overall decline in preterm births from 2014 to 2020. There was no consistent evidence of a change in the preterm birth rates following the introduction of COVID-19 mitigation measures, with difference-in-differences estimates ranging from 3.7 per 1000 births (95% confidence interval, -3.8 to 11.1) for the first 2 weeks after March 12, 2020, to -1.8 per 1000 births (95% confidence interval, -4.6 to 1.1) in the 16 weeks after March 12, 2020. Similarly, there was no evidence of an impact on medically indicated preterm birth, spontaneous preterm birth, or very preterm birth.\n\nUsing high-quality national data on births in 3 Scandinavian countries, each of which implemented different approaches to address the pandemic, there was no evidence of a decline in preterm births following the introduction of COVID-19 mitigation measures.", "doi": "10.1016/j.ajog.2021.11.034", "pmid": "34774824", "labels": {"Category: Public Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8648397"}, {"db": "pii", "key": "S0002-9378(21)01231-X"}], "notes": [], "created": "2021-11-26T14:28:58.085Z", "modified": "2023-01-13T14:47:21.250Z"}, {"entity": "publication", "iuid": "31e069a32bd145999c09803302272995", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/31e069a32bd145999c09803302272995.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/31e069a32bd145999c09803302272995"}}, "title": "Patient and public involvement in the build-up of COVID-19 testing in Sweden.", "authors": [{"family": "Fredriksson", "given": "Mio", "initials": "M", "orcid": "0000-0002-3858-3454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f57456b169b544b2889ddf447163756b.json"}}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Health Expect", "issn": "1369-7625", "volume": "25", "issue": "2", "pages": "541-548", "issn-l": null}, "abstract": "Patient and public involvement in healthcare can be particularly challenging during crises such as the COVID-19 pandemic.\n\nThe aims of the study, which focuses on COVID-19 testing in Sweden, were to explore (1) how, or to what extent, patients and members of the public were involved in decisions about the organization of COVID-19 testing during the first year of pandemic and (2) whether this was seen as feasible or desirable by regional and national stakeholders.\n\nA qualitative interview study was conducted with key organizational stakeholders at three national agencies and within three Swedish regions (n = 16).\n\nThere had been no patient and public involvement activities in the area of COVID-19 testing. The regions had, however, tried to respond to demands or critiques from patients and the public along the way and to adapt the services to respond to their preferences. The need for rapid decision-making, the uncertainty about whom to involve, as well as a hesitation about the appropriateness of involving patients and the public contributed to the lack of involvement.\n\nFuture studies on patient and public involvement during crises should address what structures need to be in place to carry out involvement successfully during crises and when to use activities with varying degrees of power or decision-making authority for patients and members of the public.\n\nFifteen members of the public contributed with short reflections on the study findings.", "doi": "10.1111/hex.13463", "pmid": "35257448", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8957722"}], "notes": [], "created": "2023-01-13T13:32:28.458Z", "modified": "2023-01-13T13:32:28.510Z"}, {"entity": "publication", "iuid": "763b1af1aa094b39ac60e0090b487a6b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/763b1af1aa094b39ac60e0090b487a6b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/763b1af1aa094b39ac60e0090b487a6b"}}, "title": "Modeling COVID-19 Mortality Across 44 Countries: Face Covering May Reduce Deaths.", "authors": [{"family": "Motallebi", "given": "Sahar", "initials": "S"}, {"family": "Cheung", "given": "Rex C Y", "initials": "RCY"}, {"family": "Mohit", "given": "Babak", "initials": "B"}, {"family": "Shahabi", "given": "Shahram", "initials": "S"}, {"family": "Alishahi Tabriz", "given": "Amir", "initials": "A"}, {"family": "Moattari", "given": "Syamak", "initials": "S"}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Am J Prev Med", "issn": "1873-2607", "volume": "62", "issue": "4", "pages": "483-491", "issn-l": null}, "abstract": "Despite ongoing efforts to vaccinate communities against COVID-19, the necessity of face mask use in controlling the pandemic remains subject to debate. Several studies have investigated face masks and COVID-19, covering smaller and less diverse populations than this study's sample. This study examines a hypothesized association of face-covering mandates with COVID-19 mortality decline across 44 countries in 2 continents.\n\nIn a retrospective cohort study, changes in COVID-19\u2012related daily mortality rate per million population from February 15 to May 31, 2020 were compared between 27 countries with and 17 countries without face mask mandates in nearly 1 billion (911,446,220 total) people. Longitudinal mixed effect modeling was applied and adjusted for over 10 relevant demographic, social, clinical, and time-dependent confounders.\n\nAverage COVID-19 mortality per million was 288.54 in countries without face mask policies and 48.40 in countries with face mask policies. In no mask countries, adjusted average daily increase was 0.1553 - 0.0017 X (days since the first case) log deaths per million, compared with 0.0900 - 0.0009 X (days since the first case) log deaths per million in the countries with a mandate. A total of 60 days into the pandemic, countries without face mask mandates had an average daily increase of 0.0533 deaths per million, compared with the average daily increase of 0.0360 deaths per million for countries with face mask mandates.\n\nThis study's significant results show that face mask mandates were associated with lower COVID-19 deaths rates than the rates in countries without mandates. These findings support the use of face masks to prevent excess COVID-19 deaths and should be advised during airborne disease epidemics.", "doi": "10.1016/j.amepre.2021.09.019", "pmid": "35305777", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0749-3797(21)00557-2"}, {"db": "pmc", "key": "PMC8580811"}], "notes": [], "created": "2022-03-23T06:16:41.748Z", "modified": "2022-04-04T07:12:28.738Z"}, {"entity": "publication", "iuid": "c57b1b3cc1e24d3e85c9a87cf3771051", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c57b1b3cc1e24d3e85c9a87cf3771051.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c57b1b3cc1e24d3e85c9a87cf3771051"}}, "title": "Long-term SARS-CoV-2-specific and cross-reactive cellular immune responses correlate with humoral responses, disease severity, and symptomatology.", "authors": [{"family": "Laur\u00e9n", "given": "Ida", "initials": "I", "orcid": "0000-0003-0041-6084", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76b14e85b56d4c898ad853659043b3b2.json"}}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/305bca9e5c6c423898c272bf06ce2f2a.json"}}, {"family": "Lord", "given": "Martin", "initials": "M"}, {"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Gabrielsson", "given": "Lena", "initials": "L"}, {"family": "Chourlia", "given": "Aikaterini", "initials": "A"}, {"family": "Amo\u00eado-Leite", "given": "Catarina", "initials": "C"}, {"family": "Josyula", "given": "Vijay S", "initials": "VS"}, {"family": "Eltahir", "given": "Mohamed", "initials": "M"}, {"family": "Kerzeli", "given": "Iliana", "initials": "I"}, {"family": "Falk", "given": "August J", "initials": "AJ", "orcid": "0000-0002-7773-1851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40d944d7fa964f4292f10012356a2730.json"}}, {"family": "Hober", "given": "Jonathan", "initials": "J"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Wiberg", "given": "Anna", "initials": "A"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Tegel", "given": "Hanna", "initials": "H"}, {"family": "Burman", "given": "Joachim", "initials": "J"}, {"family": "Xu", "given": "Feifei", "initials": "F"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Christoffersson", "given": "Gustaf", "initials": "G"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Philipson", "given": "Mia", "initials": "M"}, {"family": "D\u00f6nnes", "given": "Pierre", "initials": "P"}, {"family": "Lindsay", "given": "Robin", "initials": "R"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Mangsbo", "given": "Sara", "initials": "S", "orcid": "0000-0002-1355-2678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cf494629d8a4f9584ada4be16dff66b.json"}}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Immun Inflamm Dis", "issn": "2050-4527", "issn-l": null, "volume": "10", "issue": "4", "pages": "e595"}, "abstract": "Cellular immune memory responses post coronavirus disease 2019 (COVID-19) have been difficult to assess due to the risks of contaminating the immune response readout with memory responses stemming from previous exposure to endemic coronaviruses. The work herein presents a large-scale long-term follow-up study investigating the correlation between symptomology and cellular immune responses four to five months post seroconversion based on a unique severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific peptide pool that contains no overlapping peptides with endemic human coronaviruses.\r\n\r\nPeptide stimulated memory T cell responses were assessed with dual interferon-gamma (IFN\u03b3) and interleukin (IL)-2 Fluorospot. Serological analyses were performed using a multiplex antigen bead array.\r\n\r\nOur work demonstrates that long-term SARS-CoV-2-specific memory T cell responses feature dual IFN\u03b3 and IL-2 responses, whereas cross-reactive memory T cell responses primarily generate IFN\u03b3 in response to SARS-CoV-2 peptide stimulation. T cell responses correlated to long-term humoral immune responses. Disease severity as well as specific COVID-19 symptoms correlated with the magnitude of the SARS-CoV-2-specific memory T cell response four to five months post seroconversion.\r\n\r\nUsing a large cohort and a SARS-CoV-2-specific peptide pool we were able to substantiate that initial disease severity and symptoms correlate with the magnitude of the SARS-CoV-2-specific memory T cell responses.", "doi": "10.1002/iid3.595", "pmid": "35349756", "labels": {"Category: Health": null, "Research Area: Vaccine": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Type: Journal article": null, "Research Area: High-throughput and high-content serology": null}, "xrefs": [], "notes": [], "created": "2022-02-06T17:26:54.809Z", "modified": "2022-10-13T13:02:04.664Z"}, {"entity": "publication", "iuid": "04e91ab5621d4bb2b45f259dc93181cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/04e91ab5621d4bb2b45f259dc93181cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/04e91ab5621d4bb2b45f259dc93181cf"}}, "title": "Experiences of children with disabilities during the COVID-19 pandemic in Sweden: a qualitative interview study.", "authors": [{"family": "F\u00e4ldt", "given": "Anna Erica", "initials": "AE", "orcid": "0000-0001-7257-8758", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96a1134c3b564ce1919f212eee8d6725.json"}}, {"family": "Klint", "given": "Filippa", "initials": "F"}, {"family": "Warner", "given": "Georgina", "initials": "G"}, {"family": "Sarkadi", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "BMJ Paediatr Open", "issn": "2399-9772", "volume": "6", "issue": "1", "issn-l": null}, "abstract": "The impact of the COVID-19 pandemic on people with disabilities has been described as a 'triple jeopardy'. Not only have they experienced the negative social impacts of disease control measures, but access to required health services has been affected, and, not least, they are at increased risk of severe outcomes from COVID-19. This study aimed to determine how children with disabilities have experienced the pandemic in Sweden and its impact on their lives.\n\nSix children (5-13 years) were interviewed via video conferencing. An interview guide was adapted based on the children's communicative abilities and included augmentative and alternative communication support. Reflective field notes were included in the analysis. The data were analysed using qualitative content analysis.\n\nTwo themes were identified: The child's knowledge of Corona raises anxiety and fear; and Boring Corona makes the child even lonelier. The children had knowledge about and were worried about COVID-19, primarily about illness and death of their grandparents. The children longed for their grandparents and other social contacts at school, and life was described as boring and lonely. Many families lacked adequate tools to communicate with their children about the pandemic.\n\nGiven adequate support, children with disabilities and communication difficulties can give insights to their unique life situations. The interviewed children reported significant impact on their life and school life. Children were worried about their grandparents based on their knowledge about the virus. The enthusiasm with which the children engaged in the interviews is testament to the need and right of all children, regardless of communicative competence, to voice their experiences.", "doi": "10.1136/bmjpo-2021-001398", "pmid": "36053617", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8983410"}, {"db": "pii", "key": "10.1136/bmjpo-2021-001398"}], "notes": [], "created": "2022-10-13T13:20:57.007Z", "modified": "2023-01-13T13:52:53.701Z"}, {"entity": "publication", "iuid": "07eaf63ecf5c47c7a76c49d678fa0c9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07eaf63ecf5c47c7a76c49d678fa0c9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07eaf63ecf5c47c7a76c49d678fa0c9c"}}, "title": "Amyloid processing in COVID\u201019\u2010associated neurological syndromes", "authors": [{"family": "Ziff", "given": "Oliver J", "initials": "OJ", "orcid": "0000-0002-1504-7245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e3814923cdb142d8b934538ba2ec107d.json"}}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0002-3579-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0ae25211e354556a737b1a23c53c6e1.json"}}, {"family": "Mehta", "given": "Puja R", "initials": "PR"}, {"family": "Brown", "given": "Rachel", "initials": "R"}, {"family": "Athauda", "given": "Dilan", "initials": "D"}, {"family": "Heaney", "given": "Judith", "initials": "J"}, {"family": "Heslegrave", "given": "Amanda J", "initials": "AJ"}, {"family": "Benedet", "given": "Andrea Lessa", "initials": "AL"}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/351fab09f6e24b9f9e6695da83947cb6.json"}}, {"family": "Checkley", "given": "Anna M", "initials": "AM"}, {"family": "Houlihan", "given": "Catherine F", "initials": "CF"}, {"family": "Gauthier", "given": "Serge", "initials": "S"}, {"family": "Rosa\u2010Neto", "given": "Pedro", "initials": "P"}, {"family": "Fox", "given": "Nick C", "initials": "NC"}, {"family": "Schott", "given": "Jonathan M", "initials": "JM"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e314740b02c344d2b336a9410e28041e.json"}}, {"family": "Benjamin", "given": "Laura A", "initials": "LA", "orcid": "0000-0002-9685-1664", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15ffcba9a1b94d2d9d33c533c03a23d5.json"}}, {"family": "Paterson", "given": "Ross W", "initials": "RW", "orcid": "0000-0001-9372-3635", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/953284bd6f6b4bcb8fa1bb46644357ed.json"}}], "type": "journal-article", "published": "2022-04-00", "journal": {"title": "J Neurochem", "issn": "0022-3042", "issn-l": null, "volume": "161", "issue": "2", "pages": "146-157"}, "abstract": "SARS-CoV-2 infection can damage the nervous system with multiple neurological manifestations described. However, there is limited understanding of the mechanisms underlying COVID-19 neurological injury. This is a cross-sectional exploratory prospective biomarker cohort study of 21 patients with COVID-19 neurological syndromes (Guillain-Barre Syndrome [GBS], encephalitis, encephalopathy, acute disseminated encephalomyelitis [ADEM], intracranial hypertension, and central pain syndrome) and 23 healthy COVID-19 negative controls. We measured cerebrospinal fluid (CSF) and serum biomarkers of amyloid processing, neuronal injury (neurofilament light), astrocyte activation (GFAp), and neuroinflammation (tissue necrosis factor [TNF] \u0251, interleukin [IL]-6, IL-1\u03b2, IL-8). Patients with COVID-19 neurological syndromes had significantly reduced CSF soluble amyloid precursor protein (sAPP)-\u0251 (p = 0.004) and sAPP\u03b2 (p = 0.03) as well as amyloid \u03b2 (A\u03b2) 40 (p = 5.2 \u00d7 10-8 ), A\u03b242 (p = 3.5 \u00d7 10-7 ), and A\u03b242/A\u03b240 ratio (p = 0.005) compared to controls. Patients with COVID-19 neurological syndromes showed significantly increased neurofilament light (NfL, p = 0.001) and this negatively correlated with sAPP\u0251 and sAPP\u03b2. Conversely, GFAp was significantly reduced in COVID-19 neurological syndromes (p = 0.0001) and this positively correlated with sAPP\u0251 and sAPP\u03b2. COVID-19 neurological patients also displayed significantly increased CSF proinflammatory cytokines and these negatively correlated with sAPP\u0251 and sAPP\u03b2. A sensitivity analysis of COVID-19-associated GBS revealed a non-significant trend toward greater impairment of amyloid processing in COVID-19 central than peripheral neurological syndromes. This pilot study raises the possibility that patients with COVID-19-associated neurological syndromes exhibit impaired amyloid processing. Altered amyloid processing was linked to neuronal injury and neuroinflammation but reduced astrocyte activation.", "doi": "10.1111/jnc.15585", "pmid": "35137414", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9115071"}], "notes": [], "created": "2022-02-11T10:25:39.664Z", "modified": "2023-06-19T07:47:56.235Z"}, {"entity": "publication", "iuid": "83e75c24a2244523a1c138ab61c9f01a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/83e75c24a2244523a1c138ab61c9f01a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/83e75c24a2244523a1c138ab61c9f01a"}}, "title": "Vaccine based on folded RBD-PreS fusion protein with potential to induce sterilizing immunity to SARS-CoV-2 variants.", "authors": [{"family": "Gattinger", "given": "Pia", "initials": "P", "orcid": "0000-0001-6724-8543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d470813c45d04ab295b0df1b02d7cf93.json"}}, {"family": "Kratzer", "given": "Bernhard", "initials": "B", "orcid": "0000-0003-1091-4327", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dde68da106534c85a2fdba7bf06ce4ee.json"}}, {"family": "Tulaeva", "given": "Inna", "initials": "I", "orcid": "0000-0002-5825-2687", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34ba6b200b4540579cc8f5d732832076.json"}}, {"family": "Niespodziana", "given": "Katarzyna", "initials": "K", "orcid": "0000-0003-0700-965X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f98f53416c6439f87513dd4915f2a32.json"}}, {"family": "Ohradanova-Repic", "given": "Anna", "initials": "A", "orcid": "0000-0002-8005-8522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05059e6a105642238652352cc49b5a8b.json"}}, {"family": "Gebetsberger", "given": "Laura", "initials": "L", "orcid": "0000-0002-6480-6228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/397733c00f074e479edb225c45a62363.json"}}, {"family": "Borochova", "given": "Kristina", "initials": "K"}, {"family": "Garner-Spitzer", "given": "Erika", "initials": "E", "orcid": "0000-0002-5283-0458", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/439c4225d3da443d91bb45cb87436042.json"}}, {"family": "Trapin", "given": "Doris", "initials": "D"}, {"family": "Hofer", "given": "Gerhard", "initials": "G"}, {"family": "Keller", "given": "Walter", "initials": "W", "orcid": "0000-0002-2261-958X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24a27b24c2ad4b1883a0805fd97f0b58.json"}}, {"family": "Baumgartner", "given": "Isabella", "initials": "I"}, {"family": "Tancevski", "given": "Ivan", "initials": "I", "orcid": "0000-0001-5116-8960", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb82e679725d48748424895e3fef8fa8.json"}}, {"family": "Khaitov", "given": "Musa", "initials": "M", "orcid": "0000-0003-4961-9640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d6ec5145c294afaac62bef394042c9f.json"}}, {"family": "Karaulov", "given": "Alexander", "initials": "A"}, {"family": "Stockinger", "given": "Hannes", "initials": "H", "orcid": "0000-0001-6404-4430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/134cb6399ed043879f4f834914429698.json"}}, {"family": "Wiedermann", "given": "Ursula", "initials": "U", "orcid": "0000-0002-1302-3223", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ecada0958ed84f0186e48880c874ad07.json"}}, {"family": "Pickl", "given": "Winfried F", "initials": "WF", "orcid": "0000-0003-0430-4952", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/efd20aea311c46f7ad4a2930a5308a8c.json"}}, {"family": "Valenta", "given": "Rudolf", "initials": "R", "orcid": "0000-0001-5944-3365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46fbb364a1fd41c4a2d48836789dfd4c.json"}}], "type": "journal article", "published": "2022-03-31", "journal": {"title": "Allergy", "issn": "1398-9995", "issn-l": "0105-4538"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing global COVID-19 pandemic. One possibility to control the pandemic is to induce sterilizing immunity through the induction and maintenance of neutralizing antibodies preventing SARS-CoV-2 from entering human cells to replicate in.\n\nWe report the construction and in vitro and in vivo characterization of a SARS-CoV-2 subunit vaccine (PreS-RBD) based on a structurally folded recombinant fusion protein consisting of two SARS-CoV-2 Spike protein receptor-binding domains (RBD) fused to the N- and C-terminus of hepatitis B virus (HBV) surface antigen PreS to enable the two unrelated proteins serving as immunologic carriers for each other.\n\nPreS-RBD, but not RBD alone, induced a robust and uniform RBD-specific IgG response in rabbits. Currently available genetic SARS-CoV-2 vaccines induce mainly transient IgG1 responses in vaccinated subjects whereas the PreS-RBD vaccine induced RBD-specific IgG antibodies consisting of an early IgG1 and sustained IgG4 antibody response in a SARS-CoV-2 naive subject. PreS-RBD-specific IgG antibodies were detected in serum and mucosal secretions, reacted with SARS-CoV-2 variants, including the omicron variant of concern and the HBV receptor-binding sites on PreS of currently known HBV genotypes. PreS-RBD-specific antibodies of the immunized subject more potently inhibited the interaction of RBD with its human receptor ACE2 and their virus-neutralizing titers (VNTs) were higher than median VNTs in a random sample of healthy subjects fully immunized with registered SARS-CoV-2 vaccines or in COVID-19 convalescent subjects.\n\nThe PreS-RBD vaccine has the potential to serve as a combination vaccine for inducing sterilizing immunity against SARS-CoV-2 and HBV by stopping viral replication through the inhibition of cellular virus entry.", "doi": "10.1111/all.15305", "pmid": "35357709", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC9111473"}], "notes": [], "created": "2022-04-04T06:34:40.717Z", "modified": "2022-06-21T18:21:30.822Z"}, {"entity": "publication", "iuid": "6e24f7cb3e584302898f650734b1a74a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e24f7cb3e584302898f650734b1a74a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e24f7cb3e584302898f650734b1a74a"}}, "title": "Long-term outcomes of dexamethasone 12 mg versus 6 mg in patients with COVID-19 and severe hypoxaemia.", "authors": [{"family": "Granholm", "given": "Anders", "initials": "A"}, {"family": "Kj\u00e6r", "given": "Maj-Brit N\u00f8rregaard", "initials": "MN"}, {"family": "Munch", "given": "Marie Warrer", "initials": "MW"}, {"family": "Myatra", "given": "Sheila Nainan", "initials": "SN"}, {"family": "Vijayaraghavan", "given": "Bharath Kumar Tirupakuzhi", "initials": "BKT"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Wahlin", "given": "Rebecka Rubenson", "initials": "RR"}, {"family": "Jakob", "given": "Stephan M", "initials": "SM"}, {"family": "Cioccari", "given": "Luca", "initials": "L"}, {"family": "Vesterlund", "given": "Gitte Kingo", "initials": "GK"}, {"family": "Meyhoff", "given": "Tine Sylvest", "initials": "TS"}, {"family": "Helleberg", "given": "Marie", "initials": "M"}, {"family": "M\u00f8ller", "given": "Morten Hylander", "initials": "MH"}, {"family": "Benfield", "given": "Thomas", "initials": "T"}, {"family": "Venkatesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Hammond", "given": "Naomi E", "initials": "NE"}, {"family": "Micallef", "given": "Sharon", "initials": "S"}, {"family": "Bassi", "given": "Abhinav", "initials": "A"}, {"family": "John", "given": "Oommen", "initials": "O"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Kristiansen", "given": "Klaus Tjelle", "initials": "KT"}, {"family": "Ulrik", "given": "Charlotte Suppli", "initials": "CS"}, {"family": "J\u00f8rgensen", "given": "Vibeke Lind", "initials": "VL"}, {"family": "Smitt", "given": "Margit", "initials": "M"}, {"family": "Bestle", "given": "Morten H", "initials": "MH"}, {"family": "Andreasen", "given": "Anne Sofie", "initials": "AS"}, {"family": "Poulsen", "given": "Lone Musaeus", "initials": "LM"}, {"family": "Rasmussen", "given": "Bodil Steen", "initials": "BS"}, {"family": "Br\u00f8chner", "given": "Anne Craveiro", "initials": "AC"}, {"family": "Str\u00f8m", "given": "Thomas", "initials": "T"}, {"family": "M\u00f8ller", "given": "Anders", "initials": "A"}, {"family": "Khan", "given": "Mohd Saif", "initials": "MS"}, {"family": "Padmanaban", "given": "Ajay", "initials": "A"}, {"family": "Divatia", "given": "Jigeeshu Vasishtha", "initials": "JV"}, {"family": "Saseedharan", "given": "Sanjith", "initials": "S"}, {"family": "Borawake", "given": "Kapil", "initials": "K"}, {"family": "Kapadia", "given": "Farhad", "initials": "F"}, {"family": "Dixit", "given": "Subhal", "initials": "S"}, {"family": "Chawla", "given": "Rajesh", "initials": "R"}, {"family": "Shukla", "given": "Urvi", "initials": "U"}, {"family": "Amin", "given": "Pravin", "initials": "P"}, {"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Wamberg", "given": "Christian Aage", "initials": "CA"}, {"family": "Bose", "given": "Neeta", "initials": "N"}, {"family": "Shah", "given": "Mehul S", "initials": "MS"}, {"family": "Darfelt", "given": "Iben S", "initials": "IS"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Lange", "given": "Theis", "initials": "T"}, {"family": "Perner", "given": "Anders", "initials": "A", "orcid": "0000-0002-4668-0123", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5d5120bc69c433f9df2b929d6be905a.json"}}], "type": "journal article", "published": "2022-03-31", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "issn-l": "0342-4642"}, "abstract": "We assessed long-term outcomes of dexamethasone 12 mg versus 6 mg given daily for up to 10 days in patients with coronavirus disease 2019 (COVID-19) and severe hypoxaemia.\n\nWe assessed 180-day mortality and health-related quality of life (HRQoL) using EuroQoL (EQ)-5D-5L index values and EQ visual analogue scale (VAS) in the international, stratified, blinded COVID STEROID 2 trial, which randomised 1000 adults with confirmed COVID-19 receiving at least 10 L/min of oxygen or mechanical ventilation in 26 hospitals in Europe and India. In the HRQoL analyses, higher values indicated better outcomes, and deceased patients were given a score of zero.\n\nWe obtained vital status at 180 days for 963 of 982 patients (98.1%) in the intention-to-treat population, EQ-5D-5L index value data for 922 (93.9%) and EQ VAS data for 924 (94.1%). At 180 days, 164 of 486 patients (33.7%) had died in the 12 mg group versus 184 of 477 (38.6%) in the 6 mg group [adjusted risk difference - 4.3%; 99% confidence interval (CI) - 11.7-3.0; relative risk 0.89; 0.72-1.09; P = 0.13]. The adjusted mean differences between the 12 mg and the 6 mg groups in EQ-5D-5L index values were 0.06 (99% CI - 0.01 to 0.12; P = 0.10) and in EQ VAS scores 4 (- 3 to 10; P = 0.22).\n\nAmong patients with COVID-19 and severe hypoxaemia, dexamethasone 12 mg compared with 6 mg did not result in statistically significant improvements in mortality or HRQoL at 180 days, but the results were most compatible with benefit from the higher dose.", "doi": "10.1007/s00134-022-06677-2", "pmid": "35359168", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-022-06677-2"}, {"db": "pmc", "key": "PMC8970069"}, {"db": "ClinicalTrials.gov", "key": "NCT04509973"}], "notes": [], "created": "2022-04-04T06:33:48.635Z", "modified": "2022-04-04T06:34:05.700Z"}, {"entity": "publication", "iuid": "18980b26d5f84f00b2e0b6e40b94d549", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18980b26d5f84f00b2e0b6e40b94d549.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18980b26d5f84f00b2e0b6e40b94d549"}}, "title": "Impact of the COVID-19 pandemic on subcutaneous venous port-related complications in patients with cancer: a retrospective case-control study.", "authors": [{"family": "Dahlin", "given": "Linnea", "initials": "L", "orcid": "0000-0002-8888-6103", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8dd7b90b88c34a168048b508c6f883b1.json"}}, {"family": "Taxbro", "given": "Knut", "initials": "K"}, {"family": "Hammarskj\u00f6ld", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2022-03-31", "journal": {"title": "World J Surg Oncol", "issn": "1477-7819", "volume": "20", "issue": "1", "pages": "103", "issn-l": null}, "abstract": "Vascular access in cancer patients is of great importance in order to deliver tumour-specific therapy and continues to be so during exceptional conditions. This study aimed to examine the impact of the coronavirus disease 2019 pandemic on the care and complication rates associated with subcutaneous venous port (PORT) insertion in cancer treatment.\n\nWe retrospectively studied all adult cancer patients that received a PORT in 2020 at a Swedish county hospital, including insertion characteristics and in-dwell complication rates for up to 6 months after implantation; these estimates were compared with historic data.\n\nData from 257 patients, of which 56 were haematological patients, were included and compared with those of 168 patients in the control group. The group characteristics were similar, except for the inclusion of haematological patients in the study group. Insertion characteristics showed a shorter waiting time and higher rates of antibiotic and sedative use during the pandemic. The rates of postoperative haematoma and catheter occlusion during the study period were higher than otherwise. The rates of adverse events related to the PORT in the solid tumour group were comparable to those in the control group (18.4% vs. 14.9%). Patients with haematological malignancies were more likely to experience adverse events (37.5% vs. 18.4%) and deep venous thrombosis (7.1% vs. 1.0%) than those with solid tumours.\n\nIn conclusion, the present findings suggest that PORTs remain a safe venous access system even during a pandemic, indicating a robust vascular access service.", "doi": "10.1186/s12957-022-02568-4", "pmid": "35354461", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12957-022-02568-4"}, {"db": "pmc", "key": "PMC8967566"}], "notes": [], "created": "2022-04-04T06:35:00.532Z", "modified": "2022-04-04T06:35:10.622Z"}, {"entity": "publication", "iuid": "0b309d7eb77b4a2eb072680743bb7a12", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b309d7eb77b4a2eb072680743bb7a12.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b309d7eb77b4a2eb072680743bb7a12"}}, "title": "Validation of the Canadian French version of the fear of COVID-19 scale in the general population of Quebec.", "authors": [{"family": "Attieh", "given": "Randa", "initials": "R"}, {"family": "Koffi", "given": "Kouam\u00e9", "initials": "K"}, {"family": "Tour\u00e9", "given": "Moustapha", "initials": "M", "orcid": "0000-0002-7640-0356", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b5b37d4661e49d090af2f83a0061f8b.json"}}, {"family": "Parr-Labb\u00e9", "given": "\u00c9rica", "initials": "\u00c9"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}, {"family": "Poder", "given": "Thomas G", "initials": "TG"}], "type": "journal article", "published": "2022-03-30", "journal": {"title": "Brain Behav", "issn": "2162-3279", "pages": "e32550", "issn-l": null}, "abstract": "The purpose of this study was to develop a Canadian French translation of the fear of COVID-19 scale (FCV-19S) and assess its psychometric characteristics.\n\nA forward and backtranslation process was conducted for the Canadian French version of the FCV-19S. The guidance of the ISPOR task force for translation and cultural adaptation was followed and cognitive debriefing interviews were conducted with six citizens. The final proofread Canadian French FCV-19S was then administered to a large sample of citizens from the province of Quebec in Canada through an online survey. A quota sampling was conducted in 2020. Respondents from the survey also completed the Clinical Outcomes in Routine Evaluation (CORE)-6D and the Sense of Coherence (SOC-3) questionnaires. Several psychometric tests were performed to investigate the reliability (internal consistency) and validity of the Canadian French FCV-19S, including construct validity, concurrent validity, and Rasch analysis.\n\nThe translation process was conducted without any major difficulties. The cognitive debriefing interviews led to no change in the reconciled translation. The survey collected answers from 3428 citizens. Results indicated that the factor structure of the Canadian French FCV-19S is a unidimensional factor fitting well with the data. The scale showed adequate reliability (Cronbach's alpha of .903) and concurrent validity, as indicated by significantly negative correlation with CORE-6D (r = -.410) and SOC-3 (r = -.233). The Canadian French FCV-19S properties tested using Rasch analysis was also very satisfactory.\n\nThe results of the present study indicated that the Canadian French version of FCV-19S is a unidimensional tool with robust psychometric properties in the adult's population of all ages residing in the province of Quebec, Canada.", "doi": "10.1002/brb3.2550", "pmid": "35353955", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-04-04T06:35:37.045Z", "modified": "2022-04-04T06:35:37.121Z"}, {"entity": "publication", "iuid": "2cf3de26096e435d8fd40a28afe2228b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2cf3de26096e435d8fd40a28afe2228b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2cf3de26096e435d8fd40a28afe2228b"}}, "title": "We're on mute! Exclusion of nurses' voices in national decisions and responses to COVID-19: An international perspective.", "authors": [{"family": "Rasmussen", "given": "Bodil", "initials": "B", "orcid": "0000-0002-6789-8260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24463789a4fa42f88a120f098ce640e0.json"}}, {"family": "Holton", "given": "Sara", "initials": "S", "orcid": "0000-0001-9294-7872", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64829fda675a413fbb2b7fedb14f37a9.json"}}, {"family": "Wynter", "given": "Karen", "initials": "K", "orcid": "0000-0003-4620-7691", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a09500b4fc034472b2d89d898f9ac75e.json"}}, {"family": "Phillips", "given": "David J", "initials": "DJ"}, {"family": "David", "given": "Jennifer L", "initials": "JL", "orcid": "0000-0001-6297-6429", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/755ec5167d52464cba85ebeb62bf8dd2.json"}}, {"family": "Rothmann", "given": "Mette Juel", "initials": "MJ", "orcid": "0000-0001-6505-4163", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4fc0ce619c694a1fbd6cd042105bb3b9.json"}}, {"family": "Skjoeth", "given": "Mette Maria", "initials": "MM", "orcid": "0000-0002-3528-4619", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa8742bfe09d4ea2be9f287ff3af0d72.json"}}, {"family": "Wijk", "given": "Helle", "initials": "H", "orcid": "0000-0001-8799-6856", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d845c2268c748dba1348a56f2b82589.json"}}, {"family": "Frederiksen", "given": "Kirsten", "initials": "K", "orcid": "0000-0002-2082-7094", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/938fbb5dfb1b45329e124f17cedee58e.json"}}, {"family": "Ahlstrom", "given": "Linda", "initials": "L", "orcid": "0000-0002-3372-8722", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f026139e64a84dfe9de9cd89aca4f6f7.json"}}, {"family": "Anderson", "given": "Janet E", "initials": "JE", "orcid": "0000-0002-1452-8370", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7fde0f4a4b24d6c8e1d934b30915757.json"}}, {"family": "Harris", "given": "Ruth", "initials": "R", "orcid": "0000-0002-4377-5063", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/635193f5f85f4f62b922411377749704.json"}}, {"family": "Conolly", "given": "Anna", "initials": "A", "orcid": "0000-0002-0747-4597", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4573b079b6cc450dbe271a6bcce1ebf9.json"}}, {"family": "Kent", "given": "Bridie", "initials": "B", "orcid": "0000-0001-9550-1913", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef4f521d21324590bfe3618a30a885c8.json"}}, {"family": "Maben", "given": "Jill", "initials": "J", "orcid": "0000-0002-6168-0455", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a3518673bd24747844fff98628584e0.json"}}], "type": "editorial", "published": "2022-03-29", "journal": {"title": "J Adv Nurs", "issn": "1365-2648", "issn-l": null}, "abstract": null, "doi": "10.1111/jan.15236", "pmid": "35352392", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9111388"}], "notes": [], "created": "2022-04-04T06:36:00.777Z", "modified": "2022-06-21T18:21:06.170Z"}, {"entity": "publication", "iuid": "eb0a8f3e367944d58d8598c523376c6f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb0a8f3e367944d58d8598c523376c6f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb0a8f3e367944d58d8598c523376c6f"}}, "title": "Impacts of changes in environmental exposures and health behaviours due to the COVID-19 pandemic on cardiovascular and mental health: A comparison of Barcelona, Vienna, and Stockholm.", "authors": [{"family": "Koch", "given": "Sarah", "initials": "S"}, {"family": "Khomenko", "given": "Sasha", "initials": "S"}, {"family": "Cirach", "given": "Marta", "initials": "M"}, {"family": "Ubalde-Lopez", "given": "M\u00f2nica", "initials": "M"}, {"family": "Baclet", "given": "Sacha", "initials": "S"}, {"family": "Daher", "given": "Carolyn", "initials": "C"}, {"family": "Hidalgo", "given": "Laura", "initials": "L"}, {"family": "L\u00f5hmus", "given": "Mare", "initials": "M"}, {"family": "Rizzuto", "given": "Debora", "initials": "D"}, {"family": "Rumpler", "given": "Romain", "initials": "R"}, {"family": "Susilo", "given": "Yusak", "initials": "Y"}, {"family": "Venkataraman", "given": "Siddharth", "initials": "S"}, {"family": "Wegener", "given": "Sandra", "initials": "S"}, {"family": "Wellenius", "given": "Gregory A", "initials": "GA"}, {"family": "Woodcock", "given": "James", "initials": "J"}, {"family": "Nieuwenhuijsen", "given": "Mark", "initials": "M"}], "type": "journal article", "published": "2022-03-29", "journal": {"title": "Environ Pollut", "issn": "1873-6424", "pages": "119124", "issn-l": null}, "abstract": "Responses to COVID-19 altered environmental exposures and health behaviours associated with non-communicable diseases. We aimed to (1) quantify changes in nitrogen dioxide (NO2), noise, physical activity, and greenspace visits associated with COVID-19 policies in the spring of 2020 in Barcelona (Spain), Vienna (Austria), and Stockholm (Sweden), and (2) estimated the number of additional and prevented diagnoses of myocardial infarction (MI), stroke, depression, and anxiety based on these changes. We calculated differences in NO2, noise, physical activity, and greenspace visits between pre-pandemic (baseline) and pandemic (counterfactual) levels. With two counterfactual scenarios, we distinguished between Acute Period (March 15th - April 26th, 2020) and Deconfinement Period (May 2nd - June 30th, 2020) assuming counterfactual scenarios were extended for 12 months. Relative risks for each exposure difference were estimated with exposure-risk functions. In the Acute Period, reductions in NO2 (range of change from -16.9 \u03bcg/m3 to -1.1 \u03bcg/m3), noise (from -5 dB(A) to -2 dB(A)), physical activity (from -659 MET*min/wk to -183 MET*min/wk) and greenspace visits (from -20.2 h/m to 1.1 h/m) were largest in Barcelona and smallest in Stockholm. In the Deconfinement Period, NO2 (from -13.9 \u03bcg/m3 to -3.1 \u03bcg/m3), noise (from -3 dB(A) to -1 dB(A)), and physical activity levels (from -524 MET*min/wk to -83 MET*min/wk) remained below pre-pandemic levels in all cities. Greatest impacts were caused by physical activity reductions. If physical activity levels in Barcelona remained at Acute Period levels, increases in annual diagnoses for MI (mean: 572 (95% CI: 224, 943)), stroke (585 (6, 1156)), depression (7903 (5202, 10,936)), and anxiety (16,677 (926, 27,002)) would be anticipated. To decrease cardiovascular and mental health impacts, reductions in NO2 and noise from the first COVID-19 surge should be sustained, but without reducing physical activity. Focusing on cities' connectivity that promotes active transportation and reduces motor vehicle use assists in achieving this goal.", "doi": "10.1016/j.envpol.2022.119124", "pmid": "35367103", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0269-7491(22)00338-4"}], "notes": [], "created": "2022-04-04T06:21:29.659Z", "modified": "2022-04-04T06:21:29.689Z"}, {"entity": "publication", "iuid": "60101c2caae04a6f89bc2b6dbcaed531", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60101c2caae04a6f89bc2b6dbcaed531.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60101c2caae04a6f89bc2b6dbcaed531"}}, "title": "Self-reported mental health status of pregnant women in Sweden during the COVID-19 pandemic: a cross-sectional survey.", "authors": [{"family": "Ho-Fung", "given": "Chung", "initials": "C"}, {"family": "Andersson", "given": "Ewa", "initials": "E"}, {"family": "Hsuan-Ying", "given": "Huang", "initials": "H"}, {"family": "Acharya", "given": "Ganesh", "initials": "G", "orcid": "0000-0002-1997-3107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d1c2ac0dfb849d8b2374451e38cdcba.json"}}, {"family": "Schwank", "given": "Simone", "initials": "S"}], "type": "journal article", "published": "2022-03-28", "journal": {"title": "BMC Pregnancy Childbirth", "issn": "1471-2393", "volume": "22", "issue": "1", "pages": "260", "issn-l": null}, "abstract": "The COVID-19 pandemic has contributed to unprecedented worries and challenges for pregnant women due to social restrictions and changes in maternity care provision. We aimed to investigate the mental health impact of COVID-19 pandemic on pregnant women in Sweden and explore factors associated with poor perinatal mental health in this specific context.\n\nThis was a nation-wide cross-sectional survey of pregnant women living in Sweden. Validated questionnaires were distributed through non-profit organizations\u00b4 websites and social media channels from May 2020 to February 2021. Perinatal depression, anxiety, and acute stress reaction were assessed using the Edinburgh Postnatal Depression Scale (EPDS), Generalized Anxiety Disorder-7 (GAD-7) and Impact Event Scale (Revised) (IES-R), respectively. Sociodemographic characteristics and self-perceived mental well-being were also obtained. Factors associated with mental health outcomes were analyzed using multivariate logistic regression model.\n\nAmong a total of 470 participants, 43.2% (n = 203) reported depression (EPDS \u226513), 25.7% (n = 121) moderate to severe anxiety (GAD-7 score \u2265 10), and 23.7% (n = 110) moderate to severe acute stress reaction (IES-R \u2265 33). 27.4% participants (n = 129) expressed concerns regarding their mental well-being during the pandemic. Pregnant mothers who had sick family members reported poorer mental health outcomes than those who did not (median [Interquartile range (IQR)] EPDS scores: 14.0 [8.75-18.0] vs 11.0 [6.25-15.0], p < .001; median (IQR) GAD7 scores: 7.0 [4.0-12.25] vs 6.0 [3.0-9.0], p = .003); median (IQR) IES-R scores: 20.0 [9.0-38.0] vs 15.0 [7.0-30.0], p = .048). Logistic regression analyses revealed that risk factors for poor mental health outcomes were having a sick family member with any illness, unemployment, and experiencing a substantially stressful life event. Having a higher educational level and a younger age during the pandemic were protective.\n\nDepression and anxiety were highly prevalent among pregnant women in Sweden during the COVID-19 pandemic, indicating a need for professional mental health support for this vulnerable group of population. Unemployment was an associated risk factor whereas younger age and higher educational level were protective suggesting an important role of socio-economic factors in modulating the impact of COVID-19 pandemic on perinatal mental health.", "doi": "10.1186/s12884-022-04553-x", "pmid": "35351030", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12884-022-04553-x"}, {"db": "pmc", "key": "PMC8960205"}], "notes": [], "created": "2022-04-04T06:36:23.404Z", "modified": "2022-04-04T06:36:23.439Z"}, {"entity": "publication", "iuid": "c2a1cee2d065457ba3ed30b21ec49f01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2a1cee2d065457ba3ed30b21ec49f01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2a1cee2d065457ba3ed30b21ec49f01"}}, "title": "The Karolinska NeuroCOVID study protocol: Neurocognitive impairment, biomarkers and advanced imaging in critical care survivors.", "authors": [{"family": "Nelson", "given": "David W", "initials": "DW"}, {"family": "Granberg", "given": "Tobias", "initials": "T"}, {"family": "Andersen", "given": "Pia", "initials": "P"}, {"family": "Jokhadar", "given": "Elias", "initials": "E"}, {"family": "K\u00e5hlin", "given": "Jessica", "initials": "J"}, {"family": "Granstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Hallinder", "given": "Helena", "initials": "H"}, {"family": "Schening", "given": "Anna", "initials": "A"}, {"family": "Thunborg", "given": "Charlotta", "initials": "C"}, {"family": "Walles", "given": "H\u00e5kan", "initials": "H"}, {"family": "Hagman", "given": "G\u00f6ran", "initials": "G"}, {"family": "Shams-Latifi", "given": "Roya", "initials": "R"}, {"family": "Yu", "given": "Jimmy", "initials": "J"}, {"family": "Petersson", "given": "Sven", "initials": "S"}, {"family": "Tzortzakakis", "given": "Antonios", "initials": "A"}, {"family": "Levak", "given": "Nicholas", "initials": "N"}, {"family": "Asp\u00f6", "given": "Malin", "initials": "M"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}], "type": "journal article", "published": "2022-03-25", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172"}, "abstract": "This is the study plan of the Karolinska NeuroCOVID study, a study of neurocognitive impairment after severe COVID-19, relating post-intensive care unit (ICU) cognitive and neurological deficits to biofluid markers and MRI. The COVID-19 pandemic has posed enormous health challenges to individuals and health-care systems worldwide. An emerging feature of severe COVID-19 is that of temporary and extended neurocognitive impairment, exhibiting a myriad of symptoms and signs. The causes of this symptomatology have not yet been fully elucidated.\n\nIn this study, we aim to investigate patients treated for severe COVID-19 in the ICU, as to describe and relate serum-, plasma- and cerebrospinal fluid-borne molecular and cellular biomarkers of immune activity, coagulopathy, cerebral damage, neuronal inflammation, and degeneration, to the temporal development of structural and functional changes within the brain as evident by serial MRI and extensive cognitive assessments at 3-12 months after ICU discharge.\n\nTo date, we have performed 51 3-month follow-up MRIs in the ICU survivors. Of these, two patients (~4%) have had incidental findings on brain MRI findings requiring activation of the Incidental Findings Management Plan. Furthermore, the neuropsychological and neurological examinations have so far revealed varying and mixed patterns. Several patients expressed cognitive and/or mental concerns and fatigue, complaints closely related to brain fog.\n\nThe study goal is to gain a better understanding of the pathological mechanisms and neurological consequences of this new disease, with a special emphasis on neurodegenerative and neuroinflammatory processes, in order to identify targets of intervention and rehabilitation.", "doi": "10.1111/aas.14062", "pmid": "35332517", "labels": {"Category: Health": null, "Funder: VR": null, "Category: Biochemistry": null, "Funder: Forte": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-04-04T06:58:30.523Z", "modified": "2022-04-04T06:58:30.537Z"}, {"entity": "publication", "iuid": "3e554caa8e4348698c04b63cadcfdf08", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3e554caa8e4348698c04b63cadcfdf08.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3e554caa8e4348698c04b63cadcfdf08"}}, "title": "Outcomes of SARS-CoV-2 infection among children and young people with pre-existing rheumatic and musculoskeletal diseases.", "authors": [{"family": "Kearsley-Fleet", "given": "Lianne", "initials": "L", "orcid": "0000-0003-0377-1575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9cc64aac266462baf67998b3d49c6f7.json"}}, {"family": "Chang", "given": "Min-Lee", "initials": "ML", "orcid": "0000-0001-9868-4030", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b28b0d9449d40d4a5eb1580a78f02b7.json"}}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S", "orcid": "0000-0002-8611-162X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73b17eb08d984421847f733b7a6a49d4.json"}}, {"family": "Costello", "given": "Ruth", "initials": "R", "orcid": "0000-0003-2709-6666", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c0fe69f61b54ab89f9a3de852f872a8.json"}}, {"family": "Fingerhutov\u00e1", "given": "\u0160\u00e1rka", "initials": "\u0160", "orcid": "0000-0003-2170-2688", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a96659bf4264bf799ef50ecae0c8b37.json"}}, {"family": "\u0160vestkov\u00e1", "given": "Nat\u00e1lie", "initials": "N"}, {"family": "Belot", "given": "Alexandre", "initials": "A", "orcid": "0000-0003-4902-5332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbf2b4fa1aa14e359603cfc5fdf38439.json"}}, {"family": "Aeschlimann", "given": "Florence A", "initials": "FA", "orcid": "0000-0001-7212-9151", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fd044aff5324e22a42e0d90d2edbfea.json"}}, {"family": "Melki", "given": "Isabelle", "initials": "I", "orcid": "0000-0002-8057-333X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48f0d34d38644394a0707b1bd62d3c0e.json"}}, {"family": "Kon\u00e9-Paut", "given": "Isabelle", "initials": "I", "orcid": "0000-0001-8939-5763", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18d5124274b34a10a72a755258035099.json"}}, {"family": "Eulert", "given": "Sascha", "initials": "S", "orcid": "0000-0002-7921-708X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37cbd77e83b04c82a9b6343afcdc5c83.json"}}, {"family": "Kallinich", "given": "Tilmann", "initials": "T", "orcid": "0000-0003-2404-9397", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b028eb778594e95ade00b6e18fc6bc6.json"}}, {"family": "Berkun", "given": "Yackov", "initials": "Y", "orcid": "0000-0001-9823-4750", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32ae7278290547c58db4994ff2b9c621.json"}}, {"family": "Uziel", "given": "Yosef", "initials": "Y", "orcid": "0000-0003-4655-1652", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d555727f6aa482891e28b936a5b4419.json"}}, {"family": "Raffeiner", "given": "Bernd", "initials": "B", "orcid": "0000-0002-7719-1736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9593bcad2ce747e3a65e7160559e3f5e.json"}}, {"family": "Oliveira Ramos", "given": "Filipa", "initials": "F"}, {"family": "Clemente", "given": "Daniel", "initials": "D", "orcid": "0000-0002-1605-7488", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6527b4ae3e38472cafc253c6e0155dda.json"}}, {"family": "Dackhammar", "given": "Christina", "initials": "C", "orcid": "0000-0001-9389-4282", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd9333db812c40389d8f20149efb4f2b.json"}}, {"family": "Wulffraat", "given": "Nico M", "initials": "NM", "orcid": "0000-0001-9548-5562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a14b62a27efe4966980036c8366d557c.json"}}, {"family": "Waite", "given": "Helen", "initials": "H", "orcid": "0000-0002-8435-9496", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d33974aecf224f8a89df175a5f487c56.json"}}, {"family": "Strangfeld", "given": "Anja", "initials": "A", "orcid": "0000-0002-6233-022X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/644005e83dff44b7bdca5d2b818e17d5.json"}}, {"family": "Mateus", "given": "Elsa F", "initials": "EF", "orcid": "0000-0003-0059-2141", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cbb817ab9e6e448db217bab218522259.json"}}, {"family": "Machado", "given": "Pedro M", "initials": "PM", "orcid": "0000-0002-8411-7972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef40d1eea57946e4a37d2e92a02a47cd.json"}}, {"family": "CARRA Registry Investigators", "given": "", "initials": ""}, {"family": "COVID-19 Global Pediatric Rheumatology Database Investigators", "given": "", "initials": ""}, {"family": "Natter", "given": "Marc", "initials": "M", "orcid": "0000-0003-0748-2674", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8ebb638b08546b99ae50524ac3a41d5.json"}}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL", "orcid": "0000-0001-8242-9262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9ad49b088eb467ba6d1ca1559b88047.json"}}], "type": "journal article", "published": "2022-03-25", "journal": {"title": "Ann Rheum Dis", "issn": "1468-2060", "issn-l": null}, "abstract": "Some adults with rheumatic and musculoskeletal diseases (RMDs) are at increased risk of COVID-19-related death. Excluding post-COVID-19 multisystem inflammatory syndrome of children, children and young people (CYP) are overall less prone to severe COVID-19 and most experience a mild or asymptomatic course. However, it is unknown if CYP with RMDs are more likely to have more severe COVID-19. This analysis aims to describe outcomes among CYP with underlying RMDs with COVID-19.\n\nUsing the European Alliance of Associations for Rheumatology COVID-19 Registry, the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry, and the CARRA-sponsored COVID-19 Global Paediatric Rheumatology Database, we obtained data on CYP with RMDs who reported SARS-CoV-2 infection (presumptive or confirmed). Patient characteristics and illness severity were described, and factors associated with COVID-19 hospitalisation were investigated.\n\n607 CYP with RMDs <19 years old from 25 different countries with SARS-CoV-2 infection were included, the majority with juvenile idiopathic arthritis (JIA; n=378; 62%). Forty-three (7%) patients were hospitalised; three of these patients died. Compared with JIA, diagnosis of systemic lupus erythematosus, mixed connective tissue disease, vasculitis, or other RMD (OR 4.3; 95% CI 1.7 to 11) or autoinflammatory syndrome (OR 3.0; 95% CI 1.1 to 8.6) was associated with hospitalisation, as was obesity (OR 4.0; 95% CI 1.3 to 12).\n\nThis is the most significant investigation to date of COVID-19 in CYP with RMDs. It is important to note that the majority of CYP were not hospitalised, although those with severe systemic RMDs and obesity were more likely to be hospitalised.", "doi": "10.1136/annrheumdis-2022-222241", "pmid": "35338032", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "annrheumdis-2022-222241"}], "notes": [], "created": "2022-04-04T06:50:58.842Z", "modified": "2022-04-04T06:50:59.513Z"}, {"entity": "publication", "iuid": "ffd97f47a3b54f89af1ad45af6c5ff39", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ffd97f47a3b54f89af1ad45af6c5ff39.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ffd97f47a3b54f89af1ad45af6c5ff39"}}, "title": "Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies.", "authors": [{"family": "Hanke", "given": "Leo", "initials": "L", "orcid": "0000-0001-5514-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a35f10de4f2e4aee98278f6ab845613d.json"}}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ", "orcid": "0000-0002-0227-5636", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a612a313d5874131ba64d9811a5d4a08.json"}}, {"family": "Pankow", "given": "Alec", "initials": "A", "orcid": "0000-0001-9108-1683", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a88776116034bc79c08de50a18ad39d.json"}}, {"family": "Vidakovics", "given": "Laura Perez", "initials": "LP", "orcid": "0000-0003-4283-812X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b85cf54481e94b8c95f2bf8db1038395.json"}}, {"family": "Karl", "given": "Vivien", "initials": "V", "orcid": "0000-0001-7026-7622", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d823bd5715bd46c187e252626c726e5c.json"}}, {"family": "Kim", "given": "Changil", "initials": "C", "orcid": "0000-0003-4977-4384", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d36347170c34ca386deee72faccc534.json"}}, {"family": "Urgard", "given": "Egon", "initials": "E"}, {"family": "Smith", "given": "Natalie L", "initials": "NL"}, {"family": "Astorga-Wells", "given": "Juan", "initials": "J", "orcid": "0000-0003-1017-8841", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb77d4b2e89b4662ad360a51d0061ebf.json"}}, {"family": "Ekstr\u00f6m", "given": "Simon", "initials": "S"}, {"family": "Coquet", "given": "Jonathan M", "initials": "JM", "orcid": "0000-0002-5967-4857", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ca3e4664dc444a3a992531ad3dd9201.json"}}, {"family": "McInerney", "given": "Gerald M", "initials": "GM", "orcid": "0000-0003-2257-7241", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7770437d845444a8a07865bf5b62fab0.json"}}, {"family": "Murrell", "given": "Ben", "initials": "B", "orcid": "0000-0002-0393-4445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60dac9ecf84d4eb3b90fb4ee1298bc52.json"}}], "type": "journal article", "published": "2022-03-25", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "8", "issue": "12", "pages": "eabm0220", "issn-l": "2375-2548"}, "abstract": "Conventional approaches to isolate and characterize nanobodies are laborious. We combine phage display, multivariate enrichment, next-generation sequencing, and a streamlined screening strategy to identify numerous anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nanobodies. We characterize their potency and specificity using neutralization assays and hydrogen/deuterium exchange mass spectrometry (HDX-MS). The most potent nanobodies bind to the receptor binding motif of the receptor binding domain (RBD), and we identify two exceptionally potent members of this category (with monomeric half-maximal inhibitory concentrations around 13 and 16 ng/ml). Other nanobodies bind to a more conserved epitope on the side of the RBD and are able to potently neutralize the SARS-CoV-2 founder virus (42 ng/ml), the Beta variant (B.1.351/501Y.V2) (35 ng/ml), and also cross-neutralize the more distantly related SARS-CoV-1 (0.46 \u03bcg/ml). The approach presented here is well suited for the screening of phage libraries to identify functional nanobodies for various biomedical and biochemical applications.", "doi": "10.1126/sciadv.abm0220", "pmid": "35333580", "labels": {"Category: Health": null, "Funder: VR": null, "Category: Biochemistry": null, "Type: Journal article": null, "Funder: H2020": null}, "xrefs": [], "notes": [], "created": "2022-04-04T06:57:31.249Z", "modified": "2022-04-04T06:57:31.448Z"}, {"entity": "publication", "iuid": "d547d3166d794c54b9fcc8d4e39b1fd6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d547d3166d794c54b9fcc8d4e39b1fd6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d547d3166d794c54b9fcc8d4e39b1fd6"}}, "title": "Author Correction: Self-reported COVID-19 vaccine hesitancy and uptake among participants from different racial and ethnic groups in the United States and United Kingdom.", "authors": [{"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Merino", "given": "Jordi", "initials": "J", "orcid": "0000-0001-8312-1438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12ab049914a542b39affcfb4196861d2.json"}}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Lo", "given": "Chun-Han", "initials": "CH", "orcid": "0000-0001-8202-4513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a0d9111318f4084b64f47b5b56c8c85.json"}}, {"family": "Kwon", "given": "Sohee", "initials": "S", "orcid": "0000-0002-4201-9522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/850aeda246cd44e88071b97d54b358b5.json"}}, {"family": "Wang", "given": "Kai", "initials": "K"}, {"family": "Graham", "given": "Mark S", "initials": "MS"}, {"family": "Polidori", "given": "Lorenzo", "initials": "L"}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874802ae65824a90ba50eabdeabb8356.json"}}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Anyane-Yeboa", "given": "Adjoa", "initials": "A"}, {"family": "Astley", "given": "Christina M", "initials": "CM", "orcid": "0000-0002-5063-8470", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98ce30ec7a7d45389d75aba2defce392.json"}}, {"family": "Warner", "given": "Erica T", "initials": "ET"}, {"family": "Hu", "given": "Christina Y", "initials": "CY"}, {"family": "Selvachandran", "given": "Somesh", "initials": "S"}, {"family": "Davies", "given": "Richard", "initials": "R", "orcid": "0000-0003-2050-3994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b82cc92615f462d9af0153a6fb94fde.json"}}, {"family": "Nash", "given": "Denis", "initials": "D"}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74cf1f7094744ee289fa5df041e7cb5b.json"}}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-7284-6767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeefbf47fd384d5390109fe1a903bd18.json"}}, {"family": "COPE Consortium", "given": "", "initials": ""}], "type": "published erratum", "published": "2022-03-25", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "1715", "issn-l": "2041-1723"}, "abstract": null, "doi": "10.1038/s41467-022-29100-2", "pmid": "35338133", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-022-29100-2"}, {"db": "pmc", "key": "PMC8956141"}], "notes": [], "created": "2022-04-04T06:50:41.013Z", "modified": "2022-04-04T06:50:41.134Z"}, {"entity": "publication", "iuid": "5e72d64a6f384c0aa69b85d97a5735f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e72d64a6f384c0aa69b85d97a5735f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e72d64a6f384c0aa69b85d97a5735f0"}}, "title": "A population-based cohort approach to assess excess mortality due to the spread of COVID-19 in Italy, January-May 2020.", "authors": [{"family": "Dorrucci", "given": "Maria", "initials": "M"}, {"family": "Minelli", "given": "Giada", "initials": "G"}, {"family": "Boros", "given": "Stefano", "initials": "S"}, {"family": "Manno", "given": "Valerio", "initials": "V"}, {"family": "Prati", "given": "Sabrina", "initials": "S"}, {"family": "Battaglini", "given": "Marco", "initials": "M"}, {"family": "Corsetti", "given": "Gianni", "initials": "G"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Vescio", "given": "Maria Fenicia", "initials": "MF"}, {"family": "Spuri", "given": "Matteo", "initials": "M"}, {"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Italian Integrated Surveillance COVID-19 Group", "given": "", "initials": ""}, {"family": "Italian Integrated Surveillance COVID-19 group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-03-25", "journal": {"title": "Ann Ist Super Sanita", "issn": "2384-8553", "volume": "58", "issue": "1", "pages": "25-33", "issn-l": null}, "abstract": "To assess the impact of the COVID-19 pandemic on all-cause mortality in Italy during the first wave of the epidemic, taking into consideration the geographical heterogeneity of the spread of COVID-19.\n\nThis study is a retrospective, population-based cohort study using national statistics throughout Italy. Survival analysis was applied to data aggregated by day of death, age groups, sex, and Italian administrative units (107 provinces). We applied Cox models to estimate the relative hazards (RH) of excess mortality, comparing all-cause deaths in 2020 with the expected deaths from all causes in the same time period. The RH of excess deaths was estimated in areas with a high, moderate, and low spread of COVID-19. We reported the estimate also restricting the analysis to the period of March-April 2020 (first peak of the epidemic).\n\nThe study population consisted of 57,204,501 individuals living in Italy as of January 1, 2020. The number of excess deaths was 36,445, which accounts for 13.4% of excess mortalities from all causes during January-May 2020 (i.e., RH = 1.134; 95% confidence interval (CI): 1.129-1.140). In the macro-area with a relatively higher spread of COVID-19 (i.e., incidence rate, IR): 450-1,610 cases per 100,000 residents), the RH of excess deaths was 1.375 (95% CI: 1.364-1.386). In the area with a relatively moderate spread of COVID-19 (i.e., IR: 150-449 cases) it was 1.049 (95% CI: 1.038-1.060). In the area with a relatively lower spread of COVID-19 (i.e., IR: 30-149 cases), it was 0.967 (95% CI: 0.959-0.976). Between March and April (peak months of the first wave of the epidemic in Italy), we estimated an excess mortality from all causes of 43.5%. The RH of all-cause mortality for increments of 500 cases per 100,000 residents was 1.352 (95% CI: 1.346-1.359), corresponding to an increase of about 35%.\n\nOur analysis, making use of a population-based cohort model, estimated all-cause excess mortality in Italy taking account of both time period and of COVID-19 geographical spread. The study highlights the importance of a temporal/geographic framework in analyzing the risk of COVID-19-epidemy related mortality.", "doi": "10.4415/ANN_22_01_04", "pmid": "35324471", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Public Health": null, "Topics: Register-based research": null}, "xrefs": [], "notes": [], "created": "2022-04-04T07:00:43.085Z", "modified": "2022-04-04T07:00:52.509Z"}, {"entity": "publication", "iuid": "320c5e17ea1c4b2b94be7e555e8da3cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/320c5e17ea1c4b2b94be7e555e8da3cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/320c5e17ea1c4b2b94be7e555e8da3cb"}}, "title": "Selection analysis identifies clusters of unusual mutational changes in Omicron lineage BA.1 that likely impact Spike function.", "authors": [{"family": "Martin", "given": "Darren P", "initials": "DP", "orcid": "0000-0002-8785-0870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b43d72fdd57b4f908104e6f3056802ea.json"}}, {"family": "Lytras", "given": "Spyros", "initials": "S", "orcid": "0000-0003-4202-6682", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f440b2fe14e341bd829279d08a4a1de8.json"}}, {"family": "Lucaci", "given": "Alexander G", "initials": "AG"}, {"family": "Maier", "given": "Wolfgang", "initials": "W"}, {"family": "Gr\u00fcning", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Shank", "given": "Stephen D", "initials": "SD"}, {"family": "Weaver", "given": "Steven", "initials": "S"}, {"family": "MacLean", "given": "Oscar A", "initials": "OA", "orcid": "0000-0003-4919-4697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7169fd6ed48a4d10a0851eb90d2fb601.json"}}, {"family": "Orton", "given": "Richard J", "initials": "RJ", "orcid": "0000-0002-3389-4325", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7dae63399f52461ab68cefc6e6bc95d6.json"}}, {"family": "Lemey", "given": "Philippe", "initials": "P"}, {"family": "Boni", "given": "Maciej F", "initials": "MF"}, {"family": "Tegally", "given": "Houriiyah", "initials": "H"}, {"family": "Harkins", "given": "Gordon W", "initials": "GW"}, {"family": "Scheepers", "given": "Cathrine", "initials": "C"}, {"family": "Bhiman", "given": "Jinal N", "initials": "JN"}, {"family": "Everatt", "given": "Josie", "initials": "J"}, {"family": "Amoako", "given": "Daniel G", "initials": "DG"}, {"family": "San", "given": "James Emmanuel", "initials": "JE"}, {"family": "Giandhari", "given": "Jennifer", "initials": "J"}, {"family": "Sigal", "given": "Alex", "initials": "A", "orcid": "0000-0001-8571-2004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/197afb3112db40bd8d11247fa817b44f.json"}}, {"family": "NGS-SA", "given": "", "initials": ""}, {"family": "Williamson", "given": "Carolyn", "initials": "C"}, {"family": "Hsiao", "given": "Nei-Yuan", "initials": "NY"}, {"family": "von Gottberg", "given": "Anne", "initials": "A"}, {"family": "De Klerk", "given": "Arne", "initials": "A"}, {"family": "Shafer", "given": "Robert W", "initials": "RW"}, {"family": "Robertson", "given": "David L", "initials": "DL", "orcid": "0000-0001-6338-0221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7032efbe870440ccba1ebeed797be7b1.json"}}, {"family": "Wilkinson", "given": "Robert J", "initials": "RJ"}, {"family": "Sewell", "given": "B Trevor", "initials": "BT"}, {"family": "Lessells", "given": "Richard", "initials": "R"}, {"family": "Nekrutenko", "given": "Anton", "initials": "A", "orcid": "0000-0002-5987-8032", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e604351c6b64d15926f3392cd87ab87.json"}}, {"family": "Greaney", "given": "Allison J", "initials": "AJ"}, {"family": "Starr", "given": "Tyler N", "initials": "TN"}, {"family": "Bloom", "given": "Jesse D", "initials": "JD", "orcid": "0000-0003-1267-3408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f86f4a7b94e41358a4770ac2aa9b1b4.json"}}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Wilkinson", "given": "Eduan", "initials": "E"}, {"family": "Gupta", "given": "Ravindra K", "initials": "RK", "orcid": "0000-0001-9751-1808", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5fe96ec97d14f06a421cd22417544c9.json"}}, {"family": "de Oliveira", "given": "Tulio", "initials": "T", "orcid": "0000-0002-3027-5254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3dadcb78141a496ba76769d69667bf79.json"}}, {"family": "Kosakovsky Pond", "given": "Sergei L", "initials": "SL", "orcid": "0000-0003-4817-4029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59b8eb4236b3414291e4a0a5f81d5746.json"}}], "type": "journal article", "published": "2022-03-24", "journal": {"title": "Mol Biol Evol", "issn": "1537-1719", "issn-l": null}, "abstract": "Among the 30 non-synonymous nucleotide substitutions in the Omicron S-gene are 13 that have only rarely been seen in other SARS-CoV-2 sequences. These mutations cluster within three functionally important regions of the S-gene at sites that will likely impact (i) interactions between subunits of the Spike trimer and the predisposition of subunits to shift from down to up configurations, (ii) interactions of Spike with ACE2 receptors, and (iii) the priming of Spike for membrane fusion. We show here that, based on both the rarity of these 13 mutations in intrapatient sequencing reads and patterns of selection at the codon sites where the mutations occur in SARS-CoV-2 and related sarbecoviruses, prior to the emergence of Omicron the mutations would have been predicted to decrease the fitness of any virus within which they occurred. We further propose that the mutations in each of the three clusters therefore cooperatively interact to both mitigate their individual fitness costs, and, in combination with other mutations, adaptively alter the function of Spike. Given the evident epidemic growth advantages of Omicron over all previously known SARS-CoV-2 lineages, it is crucial to determine both how such complex and highly adaptive mutation constellations were assembled within the Omicron S-gene, and why, despite unprecedented global genomic surveillance efforts, the early stages of this assembly process went completely undetected.", "doi": "10.1093/molbev/msac061", "pmid": "35325204", "labels": {"Category: Health": null, "Category: Omicron VoC": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6553617"}], "notes": [], "created": "2022-04-04T07:00:24.978Z", "modified": "2022-04-04T07:00:25.380Z"}, {"entity": "publication", "iuid": "c9e79fd52e204fd7879a3be9141be7f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9e79fd52e204fd7879a3be9141be7f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9e79fd52e204fd7879a3be9141be7f7"}}, "title": "Role of Newly Introduced Teledentistry Service in the Management of Dental Emergencies During COVID-19 Pandemic in Qatar: A Cross-Sectional Analysis.", "authors": [{"family": "Ali", "given": "Shaymaa Abdulreda", "initials": "SA", "orcid": "0000-0003-3420-7096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5288ffb0fc4845fd82d93e3858762284.json"}}, {"family": "Al-Qahtani", "given": "Abdul Mueen A", "initials": "AMA"}, {"family": "Al Banai", "given": "Suhayla R", "initials": "SR"}, {"family": "Albaker", "given": "Fatima J", "initials": "FJ"}, {"family": "Almarri", "given": "Alanoud E", "initials": "AE"}, {"family": "Al-Haithami", "given": "Khalid", "initials": "K"}, {"family": "Khandakji", "given": "Mohannad N", "initials": "MN"}, {"family": "El Ansari", "given": "Walid", "initials": "W"}], "type": "journal article", "published": "2022-03-24", "journal": {"title": "Telemed J E Health", "issn": "1556-3669", "issn-l": null}, "abstract": "Introduction:The lockdown imposed by the COVID-19 pandemic rendered teledentistry (TD) necessary to maintain the continuity of oral health services and avoid missing emergency dental conditions, while minimizing face-to-face visits. Our objective was to evaluate the ability of a newly introduced triage-based TD service to deliver its goals, by evaluating its processes and outcomes and assessing the demand for TD. Methods:This cross-sectional report assessed the triage processes and outcomes (triage category, referral to emergency/dental facility undertaken, remote medications prescribed, and procedures performed at the point of referral); and evaluated the demand for the newly introduced TD service during 5 months of the first wave of the pandemic. Results:Of 850 calls, about 70.6% of the samples were managed remotely; 29.4% were categorized as emergency/urgent and referred to the emergency/dental facility. Compared with other complaints, orofacial dental pain was the most common reason for the calls (41.6%, p < 0.0001). About 14.71% of callers received prescription for medications remotely. The most demanded disciplines were general dentistry, orthodontics, and oral surgery, respectively (p < 0.0001). Of those referred to a dental facility, 31.84% required no clinical intervention, 28.7% received orthodontic appliance repair, and 14.3% and 11.2% had urgent dental extractions or root canal treatments. Demand on the service fluctuated through various distinct stages of the lockdown. Conclusions:There has been continuous demand for the newly introduced TD service throughout the period of the current report despite the fluctuations, with most complaints managed remotely. TD was effective and suitable for triage, service delivery, and care during the pandemic.", "doi": "10.1089/tmj.2021.0584", "pmid": "35333637", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2022-04-04T06:57:08.271Z", "modified": "2022-04-04T06:57:08.335Z"}, {"entity": "publication", "iuid": "33c17f7d64144bcbbedd0979d29ac155", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/33c17f7d64144bcbbedd0979d29ac155.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/33c17f7d64144bcbbedd0979d29ac155"}}, "title": "Interpreter-mediated interactions between people using a signed respective spoken language across distances in real time: a scoping review.", "authors": [{"family": "Warnicke", "given": "Camilla", "initials": "C"}, {"family": "Granberg", "given": "Sarah", "initials": "S"}], "type": "journal article", "published": "2022-03-24", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "volume": "22", "issue": "1", "pages": "387", "issn-l": null}, "abstract": "Communication between people who are deaf and sign and people who use a spoken language is possible by means of an interpreter. Interpreting in real time can be performed at a distance, which differs from interpreting face-to-face. Due to COVID-19, interpretation at a distance has increased.\n\nThe objective of this study was to map the existing literature to identify key characteristics by addressing the following question: What is known about interpreted mediated interactions between people using a signed respective spoken language across distances in real time?\n\nEight online databases, complemented by a search in one nonindexed journal of relevance to the review, were used to identify original studies published in 2010-2020, and 17 publications met the inclusion criteria. Charting of the data revealed insight from 17 original studies that were extracted, summarized, and reported.\n\nFour key characteristics were identified: (1) advantages and challenges in remote interpreting; (2) the need for training in remote interpreting and video relay service (VRS); (3) regulations and organizational structures of VRS; and (4) the interpreter as an active party in VRS.\n\nRemote interpreting has several challenges but also advantages. Knowledge of these kinds of interactions is limited, and further research must be initiated and realized, not least due to technological developments and the increased number of interpreting events.", "doi": "10.1186/s12913-022-07776-y", "pmid": "35331227", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-022-07776-y"}, {"db": "pmc", "key": "PMC8943107"}], "notes": [], "created": "2022-04-04T06:59:02.674Z", "modified": "2022-04-04T06:59:02.688Z"}, {"entity": "publication", "iuid": "690ccbdf2df14e38bbf07914827a68f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/690ccbdf2df14e38bbf07914827a68f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/690ccbdf2df14e38bbf07914827a68f1"}}, "title": "Association of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes.", "authors": [{"family": "Magnus", "given": "Maria C", "initials": "MC"}, {"family": "\u00d6rtqvist", "given": "Anne K", "initials": "AK"}, {"family": "Dahlqwist", "given": "Elisabeth", "initials": "E"}, {"family": "Ljung", "given": "Rickard", "initials": "R"}, {"family": "Sk\u00e5r", "given": "Fredrik", "initials": "F"}, {"family": "Oakley", "given": "Laura", "initials": "L"}, {"family": "Macsali", "given": "Ferenc", "initials": "F"}, {"family": "Pasternak", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Gjessing", "given": "H\u00e5kon K", "initials": "HK"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}], "type": "journal article", "published": "2022-03-24", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484", "volume": null, "issue": null, "pages": null}, "abstract": "Data about the safety of vaccines against SARS-CoV-2 during pregnancy are limited.\r\n\r\nTo examine the risk of adverse pregnancy outcomes after vaccination against SARS-CoV-2 during pregnancy.\r\n\r\nThis registry-based retrospective cohort study included 157 521 singleton pregnancies ending after 22 gestational weeks from January 1, 2021, until January 12, 2022 (Sweden), or January 15, 2022 (Norway). The Pregnancy Register in Sweden and the Medical Birth Registry of Norway were linked to vaccination and other registries for identification of exposure and background characteristics.\r\n\r\nData on mRNA vaccines-BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna)-and 1 viral vector vaccine-AZD1222 (AstraZeneca)-were collected from national vaccination registries.\r\n\r\nThe risk of preterm birth and stillbirth was evaluated using Cox regression models, with gestational day as the time metric and vaccination as a time-dependent exposure variable. The risk of small for gestational age, low Apgar score, and neonatal care admission was evaluated using logistic regression. Random-effects meta-analysis was used to combine results between countries.\r\n\r\nAmong the 157 521 singleton births included in the study (103 409 in Sweden and 54 112 in Norway), the mean maternal age at the time of delivery was 31 years, and 28 506 (18%) were vaccinated against SARS-CoV-2 (12.9% with BNT162b2, 4.8% with mRNA-1273, and 0.3% with AZD1222) while pregnant. A total of 0.7%, 8.3%, and 9.1% of individuals delivering were vaccinated during the first, second, and third trimester, respectively. Vaccination against SARS-CoV-2 was not significantly associated with increased risk of preterm birth (6.2 vs 4.9 per 10 000 pregnancy days; adjusted hazard ratio [aHR], 0.98 [95% CI, 0.91 to 1.05]; I2 = 0%; P for heterogeneity = .60), stillbirth (2.1 vs 2.4 per 100 000 pregnancy days; aHR, 0.86 [95% CI, 0.63 to 1.17]), small for gestational age (7.8% vs 8.5%; difference, -0.6% [95% CI, -1.3% to 0.2%]; adjusted OR [aOR], 0.97 [95% CI, 0.90 to 1.04]), low Apgar score (1.5% vs 1.6%; difference, -0.05% [95% CI, -0.3% to 0.1%]; aOR, 0.97 [95% CI, 0.87 to 1.08]), or neonatal care admission (8.5% vs 8.5%; difference, 0.003% [95% CI, -0.9% to 0.9%]; aOR, 0.97 [95% CI, 0.86 to 1.10]).\r\n\r\nIn this population-based study conducted in Sweden and Norway, vaccination against SARS-CoV-2 during pregnancy, compared with no SARS-CoV-2 vaccination during pregnancy, was not significantly associated with an increased risk of adverse pregnancy outcomes. The majority of the vaccinations were with mRNA vaccines during the second and third trimesters of pregnancy, which should be considered in interpreting the findings.", "doi": "10.1001/jama.2022.3271", "pmid": "35323851", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2790608"}], "notes": [], "created": "2022-04-04T07:01:07.549Z", "modified": "2022-04-04T07:01:45.109Z"}, {"entity": "publication", "iuid": "2c847a155f2541e8ab624cfe169d8464", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c847a155f2541e8ab624cfe169d8464.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c847a155f2541e8ab624cfe169d8464"}}, "title": "The cannabinoid receptor-1 gene interacts with stressful life events to increase the risk for problematic alcohol use.", "authors": [{"family": "Bornscheuer", "given": "Lisa", "initials": "L"}, {"family": "Lundin", "given": "Andreas", "initials": "A"}, {"family": "Forsell", "given": "Yvonne", "initials": "Y"}, {"family": "Lavebratt", "given": "Catharina", "initials": "C"}, {"family": "Melas", "given": "Philippe A", "initials": "PA"}], "type": "journal article", "published": "2022-03-23", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "4963", "issn-l": "2045-2322"}, "abstract": "Problematic alcohol use is a major contributor to the global burden of death and disabilities, and it represents a public health concern that has grown substantially following the COVID-19 pandemic. The available treatment options remain limited and to develop better pharmacotherapies for alcohol misuse we need to identify suitable biological targets. Previous research has implicated the brain's endocannabinoid system (ECS) in psychiatric and stress-related outcomes, including substance use and habituation to repeated stress. Moreover, genetic variants in the cannabinoid-1 receptor gene (CNR1; CB1R) have been associated with personality traits, which are in turn predictors of substance use disorders. To date, however, no human genome-wide association study has provided evidence for an involvement of the ECS in substance use outcomes. One reason for this ECS-related \"missing heritability\" may be unexamined gene-environment interactions. To explore this possibility, we conducted cross-sectional analyses using DNA samples and stress-exposure data from a longitudinal Swedish population-based study (N = 2,915). Specifically, we genotyped rs2023239, a functional C/T single nucleotide polymorphism in CNR1, previously reported to be associated with CNR1 binding in the brain, subjective reward following alcohol intake, and alcohol cue-elicited brain activation. Our two outcomes of interest were (i) problematic alcohol use based on the Alcohol Use Disorders Identification Test (AUDIT), and (ii) personality trait scores based on the Five Factor Model. We found no baseline association between rs2023239 and problematic alcohol use or personality traits. However, there was a clear trend for interaction between rs2023239's risk allele (C) and stressful life events (SLEs) in both childhood and adulthood, which predicted problematic alcohol use. Although not significant, there was also some indication that the risk allele interacted with child SLEs to increase scores on neuroticism. Our study supports the notion that the ECS can affect alcohol intake behaviors by interacting with life adversities and is-to the best of our knowledge-the first to focus on the interaction between CNR1 and stressors in both childhood and adulthood in humans. Further studies are warranted to confirm these findings.", "doi": "10.1038/s41598-022-08980-w", "pmid": "35322131", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-08980-w"}, {"db": "pmc", "key": "PMC8941304"}], "notes": [], "created": "2022-04-04T07:01:57.049Z", "modified": "2022-04-04T07:01:57.064Z"}, {"entity": "publication", "iuid": "036b84ea926f49ef991e707003c87736", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/036b84ea926f49ef991e707003c87736.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/036b84ea926f49ef991e707003c87736"}}, "title": "Pandemic trends in health care use: From the hospital bed to self-care with COVID-19.", "authors": [{"family": "Methi", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-7091-0806", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb34bc6f3c664b55b2240d9de0114cd4.json"}}, {"family": "Hern\u00e6s", "given": "Kjersti Helene", "initials": "KH"}, {"family": "Skyrud", "given": "Katrine Damgaard", "initials": "KD"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2022-03-23", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "3", "pages": "e0265812", "issn-l": "1932-6203"}, "abstract": "To explore whether the acute 30-day burden of COVID-19 on health care use has changed from February 2020 to February 2022.\n\nIn all Norwegians (N = 493 520) who tested positive for SARS-CoV-2 in four pandemic waves (February 26th, 2020 -February 16th, 2021 (1st wave dominated by the Wuhan strain), February 17th-July 10th, 2021 (2nd wave dominated by the Alpha variant), July 11th-December 27th, 2021 (3rd wave dominated by the Delta variant), and December 28th, 2021 -January 14th, 2022 (4th wave dominated by the Omicron variant)), we studied the age- and sex-specific share of patients (by age groups 1-19, 20-67, and 68 or more) who had: 1) Relied on self-care, 2) used outpatient care (visiting general practitioners or emergency ward for COVID-19), and 3) used inpatient care (hospitalized \u226524 hours with COVID-19).\n\nWe find a remarkable decline in the use of health care services among COVID-19 patients for all age/sex groups throughout the pandemic. From 83% [95%CI = 83%-84%] visiting outpatient care in the first wave, to 80% [81%-81%], 69% [69%-69%], and 59% [59%-59%] in the second, third, and fourth wave. Similarly, from 4.9% [95%CI = 4.7%-5.0%] visiting inpatient care in the first wave, to 3.6% [3.4%-3.7%], 1.4% [1.3%-1.4%], and 0.5% [0.4%-0.5%]. Of persons testing positive for SARS-CoV-2, 41% [41%-41%] relied on self-care in the 30 days after testing positive in the fourth wave, compared to 16% [15%-16%] in the first wave.\n\nFrom 2020 to 2022, the use of COVID-19 related outpatient care services decreased with 29%, whereas the use of COVID-19 related inpatient care services decreased with 80%.", "doi": "10.1371/journal.pone.0265812", "pmid": "35320323", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-37160"}, {"db": "pmc", "key": "PMC8942224"}], "notes": [], "created": "2022-04-04T07:02:11.806Z", "modified": "2022-04-04T07:02:11.847Z"}, {"entity": "publication", "iuid": "09c87432b4ec47b5b2ebbf1a8bad41b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/09c87432b4ec47b5b2ebbf1a8bad41b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/09c87432b4ec47b5b2ebbf1a8bad41b0"}}, "title": "Lead time of early warning by wastewater surveillance for COVID-19: geographical variations and impacting factors.", "authors": [{"family": "Kumar", "given": "Manish", "initials": "M"}, {"family": "Jiang", "given": "Guangming", "initials": "G"}, {"family": "Kumar Thakur", "given": "Alok", "initials": "A"}, {"family": "Chatterjee", "given": "Shreya", "initials": "S"}, {"family": "Bhattacharya", "given": "Tanushree", "initials": "T"}, {"family": "Mohapatra", "given": "Sanjeeb", "initials": "S"}, {"family": "Chaminda", "given": "Tushara", "initials": "T"}, {"family": "Kumar Tyagi", "given": "Vinay", "initials": "V"}, {"family": "Vithanage", "given": "Meththika", "initials": "M"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Nghiem", "given": "Long D", "initials": "LD"}, {"family": "Sarkar", "given": "Dibyendu", "initials": "D"}, {"family": "Sonne", "given": "Christian", "initials": "C"}, {"family": "Mahlknecht", "given": "J\u00fcrgen", "initials": "J"}], "type": "journal article", "published": "2022-03-23", "journal": {"title": "Chem Eng J", "issn": "1385-8947", "pages": "135936", "issn-l": null}, "abstract": "The global data on the temporal tracking of the COVID-19 through wastewater surveillance needs to be comparatively evaluated to generate a proper and precise understanding of the robustness, advantages, and sensitivity of the wastewater-based epidemiological (WBE) approach. We reviewed the current state of knowledge based on forty scientific articles pertaining to temporal variations in COVID-19 cases captured via viral RNA predictions in wastewater. This paper primarily focuses on analyzing the WBE-based temporal variation reported globally to check if the reported early warning lead-time generated through environmental surveillance is pragmatic or latent. We have compiled the geographical variations reported as lead time in various WBE reports to strike a precise correlation between COVID-19 cases and genome copies detected through wastewater surveillance, with respect to the sampling dates, separately for WASH and non-WASH countries. We highlighted sampling methods, climatic and weather conditions that significantly affected the concentration of viral SARS-CoV-2 RNA detected in wastewater, and thus the lead time reported from the various climatic zones with diverse WASH situations were different. Our major findings are: i) WBE reports around the world are not comparable, especially in terms of gene copies detected, lag-time gained between monitored RNA peak and outbreak/peak of reported case, as well as per capita RNA concentrations; ii) Varying sanitation facility and climatic conditions that impact virus degradation rate are two major interfering features limit the comparability of WBE results, and iii) WBE is better applicable to WASH countries having well-connected sewerage system.", "doi": "10.1016/j.cej.2022.135936", "pmid": "35345777", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1385-8947(22)01434-6"}, {"db": "pmc", "key": "PMC8942437"}], "notes": [], "created": "2022-04-04T06:48:56.332Z", "modified": "2022-04-04T06:48:56.349Z"}, {"entity": "publication", "iuid": "79ff04a2f9d54e14b1d6461044ebd251", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79ff04a2f9d54e14b1d6461044ebd251.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79ff04a2f9d54e14b1d6461044ebd251"}}, "title": "Interactions between glucosides of the tip of the S1 subunit of SARS-CoV-2 spike protein and dry and wet surfaces of CuO and Cu-A model for the surfaces of coinage metals.", "authors": [{"family": "Lousada", "given": "Cl\u00e1udio M", "initials": "CM"}], "type": "journal article", "published": "2022-03-23", "journal": {"title": "Colloids Surf B Biointerfaces", "issn": "1873-4367", "volume": "214", "pages": "112465", "issn-l": null}, "abstract": "Despite their importance there is little knowledge at the atomic scale on the interactions between fragments of SARS-CoV-2 and inorganic materials. Such knowledge is important to understand the survival of the virus at surfaces and for the development of antiviral materials. Here is reported a study of the interactions between glucoside monomers of the tip of the S1 subunit of SARS-CoV-2 spike protein with dry and wet surfaces of CuO and Cu, performed with dispersion corrected density functional theory-DFT. The three glucoside monomers that constitute the tip of S1: 6VSB, 6VXX and 6X6P, were adsorbed onto dry and wet CuO(111) and Cu(110) with different orientations and surface alignments. There are large differences-of up to 1.3 eV-in binding energies between these monomers and the surfaces. These differences depend on: the type of surface; if the surface is wet or dry; if the glucosidic O-atom points towards or away from the surfaces; and to a smaller extent on the surface alignment of the monomers. All monomers bind strongly to the surfaces via molecular adsorption that does not involve bond breaking in the monomers at this stage. 6VSB has the larger adsorption energies-that reach 2.2 eV-due to its larger dipole moment. Both materials bind the monomers more strongly when their surfaces are dry. At Cu(110) the bonds are on average 1 eV stronger when the surface is dry when compared to wet. The difference between dry and wet CuO(111) is smaller, in the order of 0.2 eV. Overall, it is here shown that the stability of the monomers of the tip of the spike protein of the virus is very different at different surfaces. For a given surface the larger binding energies in dry conditions could explain the differences in the surface stability of the spike protein depending on the presence of moisture.", "doi": "10.1016/j.colsurfb.2022.112465", "pmid": "35334309", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0927-7765(22)00148-5"}, {"db": "pmc", "key": "PMC8940556"}], "notes": [], "created": "2022-04-04T06:56:25.566Z", "modified": "2022-04-04T06:56:25.600Z"}, {"entity": "publication", "iuid": "645d7465d1d240e586809755a25e4438", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/645d7465d1d240e586809755a25e4438.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/645d7465d1d240e586809755a25e4438"}}, "title": "Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19.", "authors": [{"family": "Abraham", "given": "George R", "initials": "GR"}, {"family": "Kuc", "given": "Rhoda E", "initials": "RE"}, {"family": "Althage", "given": "Magnus", "initials": "M"}, {"family": "Greasley", "given": "Peter J", "initials": "PJ"}, {"family": "Ambery", "given": "Philip", "initials": "P"}, {"family": "Maguire", "given": "Janet J", "initials": "JJ"}, {"family": "Wilkinson", "given": "Ian B", "initials": "IB"}, {"family": "Hoole", "given": "Stephen P", "initials": "SP"}, {"family": "Cheriyan", "given": "Joseph", "initials": "J"}, {"family": "Davenport", "given": "Anthony P", "initials": "AP"}], "type": "journal article", "published": "2022-03-23", "journal": {"title": "J Mol Cell Cardiol", "issn": "1095-8584", "issn-l": null}, "abstract": "Virus induced endothelial dysregulation is a well-recognised feature of severe Covid-19 infection. Endothelin-1 (ET-1) is the most highly expressed peptide in endothelial cells and a potent vasoconstrictor, thus representing a potential therapeutic target. ET-1 plasma levels were measured in a cohort of 194 Covid-19 patients stratified according to the clinical severity of their illness. Hospitalised patients, including those who died and those developing acute myocardial or kidney injury, had significantly elevated ET-1 plasma levels during the acute phase of infection. The results support the hypothesis that endothelin receptor antagonists may provide clinical benefit for certain Covid-19 patients.", "doi": "10.1016/j.yjmcc.2022.03.007", "pmid": "35339512", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S0022-2828(22)00051-7"}, {"db": "pmc", "key": "PMC8941861"}], "notes": [], "created": "2022-04-04T06:50:16.165Z", "modified": "2022-04-04T06:50:22.716Z"}, {"entity": "publication", "iuid": "9f671df3137144f6a38f39a6187293ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f671df3137144f6a38f39a6187293ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f671df3137144f6a38f39a6187293ee"}}, "title": "Unraveling COVID-19: A Large-Scale Characterization of 4.5 Million COVID-19 Cases Using CHARYBDIS.", "authors": [{"family": "Kostka", "given": "Kristin", "initials": "K", "orcid": "0000-0003-2595-8736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9675cf1b775341f6a3521c7dde950262.json"}}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T", "orcid": "0000-0002-8274-0357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11fd8deb257445e7a93a0a3098b246df.json"}}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A", "orcid": "0000-0003-1202-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47f086bb6ccd49a2a5f11a32c06277c8.json"}}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Pistillo", "given": "Andrea", "initials": "A", "orcid": "0000-0002-4467-0220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/055156368b8845a0bfdc522a53cc1b0d.json"}}, {"family": "Khalid", "given": "Sara", "initials": "S"}, {"family": "Lai", "given": "Lana Y H", "initials": "LYH"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM", "orcid": "0000-0002-5630-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5162aab03bc04dafa809108461f18667.json"}}, {"family": "Dawoud", "given": "Dalia M", "initials": "DM"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Wilcox", "given": "Adam B", "initials": "AB"}, {"family": "Andryc", "given": "Alan", "initials": "A", "orcid": "0000-0002-2663-2298", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9643da291a2b4aee87e4406e36cf6d16.json"}}, {"family": "Williams", "given": "Andrew", "initials": "A"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Jung", "given": "Chi Young", "initials": "CY"}, {"family": "Harle", "given": "Christopher A", "initials": "CA"}, {"family": "Reich", "given": "Christian G", "initials": "CG", "orcid": "0000-0002-3641-055X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6982fa4f228643c6bac91609a0b336d3.json"}}, {"family": "Blacketer", "given": "Clair", "initials": "C"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Dorr", "given": "David A", "initials": "DA"}, {"family": "Burn", "given": "Edward", "initials": "E", "orcid": "0000-0002-9286-1128", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cbd60c98f85a4067aec58f7b7819800c.json"}}, {"family": "Roel", "given": "Elena", "initials": "E"}, {"family": "Tan", "given": "Eng Hooi", "initials": "EH"}, {"family": "Minty", "given": "Evan", "initials": "E"}, {"family": "DeFalco", "given": "Frank", "initials": "F"}, {"family": "de Maeztu", "given": "Gabriel", "initials": "G"}, {"family": "Lipori", "given": "Gigi", "initials": "G"}, {"family": "Alghoul", "given": "Hiba", "initials": "H", "orcid": "0000-0001-8234-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e3deb1abdf54088a29dee7675a18697.json"}}, {"family": "Zhu", "given": "Hong", "initials": "H"}, {"family": "Thomas", "given": "Jason A", "initials": "JA"}, {"family": "Bian", "given": "Jiang", "initials": "J"}, {"family": "Park", "given": "Jimyung", "initials": "J", "orcid": "0000-0002-6998-2546", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa24df935da248cc94db2e63b09a3113.json"}}, {"family": "Mart\u00ednez Rold\u00e1n", "given": "Jordi", "initials": "J"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Banda", "given": "Juan M", "initials": "JM", "orcid": "0000-0001-8499-824X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab57c692026c41f4a50b7dd737594725.json"}}, {"family": "Horcajada", "given": "Juan P", "initials": "JP", "orcid": "0000-0001-9873-5459", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b302a6caec0949c6a652ab115ae8658f.json"}}, {"family": "Kohler", "given": "Julianna", "initials": "J"}, {"family": "Shah", "given": "Karishma", "initials": "K"}, {"family": "Natarajan", "given": "Karthik", "initials": "K", "orcid": "0000-0002-9066-9431", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d68e1b4844f408991c3f79af134ca15.json"}}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Liu", "given": "Li", "initials": "L", "orcid": "0000-0002-5265-4159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/232e751324fa46f3baa9ad4c008d1b99.json"}}, {"family": "Schilling", "given": "Lisa M", "initials": "LM"}, {"family": "Recalde", "given": "Martina", "initials": "M"}, {"family": "Spotnitz", "given": "Matthew", "initials": "M"}, {"family": "Gong", "given": "Mengchun", "initials": "M"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Valveny", "given": "Neus", "initials": "N", "orcid": "0000-0003-1105-5018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b4965da861b4b41a6ed0cd38bce356a.json"}}, {"family": "Weiskopf", "given": "Nicole G", "initials": "NG"}, {"family": "Shah", "given": "Nigam", "initials": "N"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Casajust", "given": "Paula", "initials": "P", "orcid": "0000-0003-2733-5436", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8a3feb959bd461c8c4ad81fcd9dee8b.json"}}, {"family": "Park", "given": "Rae Woong", "initials": "RW"}, {"family": "Schuff", "given": "Robert", "initials": "R"}, {"family": "Seager", "given": "Sarah", "initials": "S"}, {"family": "DuVall", "given": "Scott L", "initials": "SL", "orcid": "0000-0002-4898-3865", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd524264c46548cf861123d43d57151a.json"}}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Song", "given": "Seokyoung", "initials": "S", "orcid": "0000-0002-5653-7005", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92e87edc601f49f8ad197e84d690ed36.json"}}, {"family": "Fern\u00e1ndez-Bertol\u00edn", "given": "Sergio", "initials": "S"}, {"family": "Fortin", "given": "Stephen", "initials": "S"}, {"family": "Magoc", "given": "Tanja", "initials": "T", "orcid": "0000-0001-8213-2266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c3bdfe4f6d9f4d0497d28d18a1baea2e.json"}}, {"family": "Falconer", "given": "Thomas", "initials": "T", "orcid": "0000-0001-6904-1394", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39f9b217653b4b3d8ad2b4ce30d1ca80.json"}}, {"family": "Subbian", "given": "Vignesh", "initials": "V"}, {"family": "Huser", "given": "Vojtech", "initials": "V"}, {"family": "Ahmed", "given": "Waheed-Ul-Rahman", "initials": "WU", "orcid": "0000-0003-0880-0355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27d074e0c92342d299e693d12173356c.json"}}, {"family": "Carter", "given": "William", "initials": "W", "orcid": "0000-0001-5346-3453", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8dcef685912942dca4ed5e04c68c4f9c.json"}}, {"family": "Guan", "given": "Yin", "initials": "Y"}, {"family": "Galvan", "given": "Yankuic", "initials": "Y"}, {"family": "He", "given": "Xing", "initials": "X"}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Ryan", "given": "Patrick B", "initials": "PB"}, {"family": "Suchard", "given": "Marc A", "initials": "MA", "orcid": "0000-0001-9818-479X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f920e0e55c94e91b4dcff796bd24246.json"}}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D", "orcid": "0000-0002-3950-6346", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1c3f99e11244a3b90ba881356d3e259.json"}}], "type": "journal article", "published": "2022-03-22", "journal": {"title": "CLEP", "issn": "1179-1349", "volume": "14", "pages": "369-384", "issn-l": null}, "abstract": "Routinely collected real world data (RWD) have great utility in aiding the novel coronavirus disease (COVID-19) pandemic response. Here we present the international Observational Health Data Sciences and Informatics (OHDSI) Characterizing Health Associated Risks and Your Baseline Disease In SARS-COV-2 (CHARYBDIS) framework for standardisation and analysis of COVID-19 RWD.\n\nWe conducted a descriptive retrospective database study using a federated network of data partners in the United States, Europe (the Netherlands, Spain, the UK, Germany, France and Italy) and Asia (South Korea and China). The study protocol and analytical package were released on 11th June 2020 and are iteratively updated via GitHub. We identified three non-mutually exclusive cohorts of 4,537,153 individuals with a clinical COVID-19 diagnosis or positive test, 886,193 hospitalized with COVID-19, and 113,627 hospitalized with COVID-19 requiring intensive services.\n\nWe aggregated over 22,000 unique characteristics describing patients with COVID-19. All comorbidities, symptoms, medications, and outcomes are described by cohort in aggregate counts and are readily available online. Globally, we observed similarities in the USA and Europe: more women diagnosed than men but more men hospitalized than women, most diagnosed cases between 25 and 60 years of age versus most hospitalized cases between 60 and 80 years of age. South Korea differed with more women than men hospitalized. Common comorbidities included type 2 diabetes, hypertension, chronic kidney disease and heart disease. Common presenting symptoms were dyspnea, cough and fever. Symptom data availability was more common in hospitalized cohorts than diagnosed.\n\nWe constructed a global, multi-centre view to describe trends in COVID-19 progression, management and evolution over time. By characterising baseline variability in patients and geography, our work provides critical context that may otherwise be misconstrued as data quality issues. This is important as we perform studies on adverse events of special interest in COVID-19 vaccine surveillance.", "doi": "10.2147/CLEP.S323292", "pmid": "35345821", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "323292"}, {"db": "pmc", "key": "PMC8957305"}], "notes": [], "created": "2022-04-04T06:48:36.538Z", "modified": "2022-04-04T06:48:37.014Z"}, {"entity": "publication", "iuid": "ca51b638da9740ca8c52978f961759b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ca51b638da9740ca8c52978f961759b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ca51b638da9740ca8c52978f961759b1"}}, "title": "Current Approaches to Vaccine Safety Using Observational Data: A Rationale for the EUMAEUS (Evaluating Use of Methods for Adverse Events Under Surveillance-for Vaccines) Study Design.", "authors": [{"family": "Lai", "given": "Lana Yh", "initials": "LY"}, {"family": "Arshad", "given": "Faaizah", "initials": "F"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "Li", "given": "Xintong", "initials": "X"}, {"family": "Dawoud", "given": "Dalia", "initials": "D"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Pratt", "given": "Nicole", "initials": "N"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Prieto-Alhambra", "given": "Dani", "initials": "D"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Schuemie", "given": "Martijn J", "initials": "MJ"}], "type": "journal article", "published": "2022-03-22", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "issn-l": "1663-9812", "volume": "13", "issue": null, "pages": "837632"}, "abstract": "Post-marketing vaccine safety surveillance aims to detect adverse events following immunization in a population. Whether certain methods of surveillance are more precise and unbiased in generating safety signals is unclear. Here, we synthesized information from existing literature to provide an overview of the strengths, weaknesses, and clinical applications of epidemiologic and analytical methods used in vaccine monitoring, focusing on cohort, case-control and self-controlled designs. These designs are proposed to be evaluated in the EUMAEUS (Evaluating Use of Methods for Adverse Event Under Surveillance-for vaccines) study because of their widespread use and potential utility. Over the past decades, there have been an increasing number of epidemiological study designs used for vaccine safety surveillance. While traditional cohort and case-control study designs remain widely used, newer, novel designs such as the self-controlled case series and self-controlled risk intervals have been developed. Each study design comes with its strengths and limitations, and the most appropriate study design will depend on availability of resources, access to records, number and distribution of cases, and availability of population coverage data. Several assumptions have to be made while using the various study designs, and while the goal is to mitigate any biases, violations of these assumptions are often still present to varying degrees. In our review, we discussed some of the potential biases (i.e., selection bias, misclassification bias and confounding bias), and ways to mitigate them. While the types of epidemiological study designs are well established, a comprehensive comparison of the analytical aspects (including method evaluation and performance metrics) of these study designs are relatively less well studied. We summarized the literature, reporting on two simulation studies, which compared the detection time, empirical power, error rate and risk estimate bias across the above-mentioned study designs. While these simulation studies provided insights on the analytic performance of each of the study designs, its applicability to real-world data remains unclear. To bridge that gap, we provided the rationale of the EUMAEUS study, with a brief description of the study design; and how the use of real-world multi-database networks can provide insights into better methods evaluation and vaccine safety surveillance.", "doi": "10.3389/fphar.2022.837632", "pmid": "35392566", "labels": {"Category: Vaccines": null, "Category: Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8980923"}, {"db": "pii", "key": "837632"}], "notes": [], "created": "2023-01-13T09:52:58.045Z", "modified": "2023-01-13T09:53:58.946Z"}, {"entity": "publication", "iuid": "c621ce38cce94a0bb966a7b453952c00", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c621ce38cce94a0bb966a7b453952c00.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c621ce38cce94a0bb966a7b453952c00"}}, "title": "BMI, sex and outcomes in hospitalised patients in western Sweden during the COVID-19 pandemic.", "authors": [{"family": "Lindgren", "given": "Martin", "initials": "M"}, {"family": "Toska", "given": "Triantafyllia", "initials": "T"}, {"family": "Alex", "given": "Christian", "initials": "C"}, {"family": "Lundberg", "given": "Christina E", "initials": "CE"}, {"family": "Cronie", "given": "Ottmar", "initials": "O"}, {"family": "Rosengren", "given": "Annika", "initials": "A"}, {"family": "Adiels", "given": "Martin", "initials": "M"}, {"family": "Sj\u00f6land", "given": "Helen", "initials": "H"}], "type": "journal article", "published": "2022-03-22", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "4918", "issn-l": "2045-2322"}, "abstract": "High body mass index (BMI) is associated with severe COVID-19 but findings regarding the need of intensive care (IC) and mortality are mixed. Using electronic health records, we identified all patients in western Sweden hospitalised with COVID-19 to evaluate 30-day mortality or assignment to IC. Adjusted logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for outcomes. Of totally 9761 patients, BMI was available in 7325 (75%), included in the study. There was a marked inverse association between BMI and age (underweight and normal weight patients were on average 78 and 75 years, whereas overweight and obese were 68 and 62 years). While older age, male sex and several comorbidities associated with higher mortality after multivariable adjustment, BMI did not. However, BMI \u2265 30 kg/m2 (OR 1.46, 95% CI 1.21-1.75) was associated with need of IC; this association was restricted to women (BMI \u2265 30; OR 1.96 (95% CI 1.41-2.73), and not significant in men; OR 1.22 (95% CI 0.97-1.54). In this comprehensive hospital population with COVID-19, BMI was not associated with 30-day mortality risk. Among the obese, women, but not men, had a higher risk of assignment to IC.", "doi": "10.1038/s41598-022-09027-w", "pmid": "35318438", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8939489"}, {"db": "pii", "key": "10.1038/s41598-022-09027-w"}], "notes": [], "created": "2022-04-04T07:10:13.488Z", "modified": "2023-01-13T13:51:25.566Z"}, {"entity": "publication", "iuid": "7bd80e6ae702469a84e47666eea3e837", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7bd80e6ae702469a84e47666eea3e837.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7bd80e6ae702469a84e47666eea3e837"}}, "title": "Psychological Health and Digital Social Participation of the Older Adults during the COVID-19 Pandemic in Blekinge, Sweden-An Exploratory Study.", "authors": [{"family": "Ghazi", "given": "Sarah Nauman", "initials": "SN", "orcid": "0000-0001-8114-8813", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/100ab0ff0c8d4d0cbd2c29e1e9639099.json"}}, {"family": "Anderberg", "given": "Peter", "initials": "P", "orcid": "0000-0001-9870-8477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b827b4a21b643908e4f069979dd948b.json"}}, {"family": "Berglund", "given": "Johan Sanmartin", "initials": "JS", "orcid": "0000-0003-4312-2246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ecd51160e1e412baa035f8e78150d6e.json"}}, {"family": "Berner", "given": "Jessica", "initials": "J", "orcid": "0000-0002-2848-2377", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d14099d99cf4840b3f27c24929ffcb1.json"}}, {"family": "Dallora", "given": "Ana Luiza", "initials": "AL", "orcid": "0000-0002-6752-017X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc6a17faba5a434ba9b6fc8cfbb6a1dc.json"}}], "type": "journal article", "published": "2022-03-21", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "6", "issn-l": null}, "abstract": "COVID-19 has affected the psychological health of older adults directly and indirectly through recommendations of social distancing and isolation. Using the internet or digital tools to participate in society, one might mitigate the effects of COVID-19 on psychological health. This study explores the social participation of older adults through internet use as a social platform during COVID-19 and its relationship with various psychological health aspects. In this study, we used the survey as a research method, and we collected data through telephonic interviews; and online and paper-based questionnaires. The results showed an association of digital social participation with age and feeling lack of company. Furthermore, in addition, to the increase in internet use in older adults in Sweden during COVID-19, we conclude that digital social participation is essential to maintain psychological health in older adults.", "doi": "10.3390/ijerph19063711", "pmid": "35329398", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8954168"}, {"db": "pii", "key": "ijerph19063711"}], "notes": [], "created": "2022-04-04T06:59:37.623Z", "modified": "2023-01-13T13:54:33.282Z"}, {"entity": "publication", "iuid": "0086246b36c84a929b363e65a2c76447", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0086246b36c84a929b363e65a2c76447.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0086246b36c84a929b363e65a2c76447"}}, "title": "No man is an island: management of the emergency response to the SARS-CoV-2 (COVID-19) outbreak in a large public decentralised service delivery organisation.", "authors": [{"family": "Ohrling", "given": "Mikael", "initials": "M"}, {"family": "Solberg Carlsson", "given": "Karin", "initials": "K"}, {"family": "Brommels", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2022-03-21", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "volume": "22", "issue": "1", "pages": "371", "issn-l": null}, "abstract": "We wanted to better understand whether and how agility can be achieved in a decentralised service delivery organisation in Sweden. The pandemic outbreak of SARS-Cov-2 (Covid-19) provided an opportunity to assess decentralisation as a strategy to improve the responsiveness of healthcare and at the same time handle an unpredictable and unexpected event.\n\nData from in-depth interviews with a crisis management team (n = 23) and free text answers in a weekly survey to subordinated clinical directors, i.e. unit managers, (n = 108) were scrutinised in a directed content analysis. Dynamic capabilities as a prerequisite for dynamic effectiveness, understood as reaching strategic and operative effectiveness simultaneously, were explored by using three frameworks for dynamic effectiveness, dynamic capabilities and delegated authority in a decentralised organisation.\n\nUnpredictable events, such as the pandemic Covid-19 outbreak, demand a high grade of ability to be flexible. We find that a high degree of operational effectiveness, which is imperative in an emergency situation, also is a driver of seeking new strategic positions to even better meet new demands. The characteristics of the dynamic capabilities evolving from this process are described and discussed in relation to decentralisation, defined by decision space, organisational and individual capacity as well as accountability. We present arguments supporting that a decentralised management model can facilitate the agility required in an emergency.\n\nThis study is, to our knowledge, the first of its kind where a decentralised management model in a service delivery organisation in healthcare is studied in relation to crisis management. Although stemming from one organisation, our findings indicating the value of decentralisation in situations of crisis are corroborated by theory, suggesting that they could be relevant in other organisational settings also.", "doi": "10.1186/s12913-022-07716-w", "pmid": "35313891", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-022-07716-w"}, {"db": "pmc", "key": "PMC8935606"}], "notes": [], "created": "2022-03-23T06:14:10.289Z", "modified": "2022-04-04T07:11:17.984Z"}, {"entity": "publication", "iuid": "fb52b1f6da5e4ee0881b3ae3dfb465f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb52b1f6da5e4ee0881b3ae3dfb465f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb52b1f6da5e4ee0881b3ae3dfb465f4"}}, "title": "Improved Binding Affinity of Omicron's Spike Protein for the Human Angiotensin-Converting Enzyme 2 Receptor Is the Key behind Its Increased Virulence.", "authors": [{"family": "Kumar", "given": "Rajender", "initials": "R"}, {"family": "Murugan", "given": "Natarajan Arul", "initials": "NA", "orcid": "0000-0003-0185-5724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/293acfd743f94993bd6aca57b01cd604.json"}}, {"family": "Srivastava", "given": "Vaibhav", "initials": "V", "orcid": "0000-0003-1877-4154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f6299b3ddf14b88866157ec4b4113b0.json"}}], "type": "journal article", "published": "2022-03-21", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "23", "issue": "6", "issn-l": null}, "abstract": "The new variant of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), Omicron, has been quickly spreading in many countries worldwide. Compared to the original virus, Omicron is characterized by several mutations in its genomic region, including the spike protein's receptor-binding domain (RBD). We have computationally investigated the interaction between the RBD of both the wild type and Omicron variant of SARS-CoV-2 with the human angiotensin-converting enzyme 2 (hACE2) receptor using molecular dynamics and molecular mechanics-generalized Born surface area (MM-GBSA)-based binding free energy calculations. The mode of the interaction between Omicron's RBD with the hACE2 receptor is similar to the original SARS-CoV-2 RBD except for a few key differences. The binding free energy difference shows that the spike protein of Omicron has an increased affinity for the hACE2 receptor. The mutated residues in the RBD showed strong interactions with a few amino acid residues of hACE2. More specifically, strong electrostatic interactions (salt bridges) and hydrogen bonding were observed between R493 and R498 residues of the Omicron RBD with D30/E35 and D38 residues of the hACE2, respectively. Other mutated amino acids in the Omicron RBD, e.g., S496 and H505, also exhibited hydrogen bonding with the hACE2 receptor. A pi-stacking interaction was also observed between tyrosine residues (RBD-Tyr501: hACE2-Tyr41) in the complex, which contributes majorly to the binding free energies and suggests that this is one of the key interactions stabilizing the formation of the complex. The resulting structural insights into the RBD:hACE2 complex, the binding mode information within it, and residue-wise contributions to the free energy provide insight into the increased transmissibility of Omicron and pave the way to design and optimize novel antiviral agents.", "doi": "10.3390/ijms23063409", "pmid": "35328828", "labels": {"Category: Health": null, "Category: Omicron VoC": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijms23063409"}, {"db": "pmc", "key": "PMC8955673"}], "notes": [], "created": "2022-04-04T06:59:54.410Z", "modified": "2022-04-04T06:59:54.512Z"}, {"entity": "publication", "iuid": "ecdade19e7e247f18497e4508d9ea7b6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ecdade19e7e247f18497e4508d9ea7b6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ecdade19e7e247f18497e4508d9ea7b6"}}, "title": "Fear of COVID-19 and its association with mental health-related factors: systematic review and meta-analysis.", "authors": [{"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Ohayon", "given": "Maurice M", "initials": "MM", "orcid": "0000-0002-2757-5440", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11af7871e5f948c0b730031f9b2fc03f.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2022-03-21", "journal": {"title": "BJPsych Open", "issn": "2056-4724", "volume": "8", "issue": "2", "pages": "e73", "issn-l": null}, "abstract": "The severity of COVID-19 remains high worldwide. Therefore, millions of individuals are likely to suffer from fear of COVID-19 and related mental health factors.\n\nThe present systematic review and meta-analysis aimed to synthesize empirical evidence to understand fear of COVID-19 and its associations with mental health-related problems during this pandemic period.\n\nRelevant studies were searched for on five databases (Scopus, ProQuest, EMBASE, PubMed Central, and ISI Web of Knowledge), using relevant terms (COVID-19-related fear, anxiety, depression, mental health-related factors, mental well-being and sleep problems). All studies were included for analyses irrespective of their methodological quality, and the impact of quality on pooled effect size was examined by subgroup analysis.\n\nThe meta-analysis pooled data from 91 studies comprising 88 320 participants (mean age 38.88 years; 60.66% females) from 36 countries. The pooled estimated mean of fear of COVID-19 was 13.11 (out of 35), using the Fear of COVID-19 Scale. The associations between fear of COVID-19 and mental health-related factors were mostly moderate (Fisher's z = 0.56 for mental health-related factors; 0.54 for anxiety; 0.42 for stress; 0.40 for depression; 0.29 for sleep problems and -0.24 for mental well-being). Methodological quality did not affect these associations.\n\nFear of COVID-19 has associations with various mental health-related factors. Therefore, programmes for reducing fear of COVID-19 and improving mental health are needed.", "doi": "10.1192/bjo.2022.26", "pmid": "35307051", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2056472422000266"}, {"db": "pmc", "key": "PMC8943231"}], "notes": [], "created": "2022-03-23T06:15:25.083Z", "modified": "2022-04-04T07:11:41.809Z"}, {"entity": "publication", "iuid": "2465b2a255c449c98dbe9eb9e8e85164", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2465b2a255c449c98dbe9eb9e8e85164.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2465b2a255c449c98dbe9eb9e8e85164"}}, "title": "The Swedish gamble: trust in the government and self-efficacy in the battle to combat COVID-19.", "authors": [{"family": "Hassan", "given": "Mohammed Salah", "initials": "MS", "orcid": "0000-0002-1742-2790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e712ec5774ec44d5a84da8da847ec9e9.json"}}, {"family": "Al Halbusi", "given": "Hussam", "initials": "H"}, {"family": "Razali", "given": "Asbah", "initials": "A"}, {"family": "Ariffin", "given": "Raja Noriza Raja", "initials": "RNR"}, {"family": "Williams", "given": "Kent A", "initials": "KA"}], "type": "journal article", "published": "2022-03-19", "journal": {"title": "Curr Psychol", "issn": "1046-1310", "pages": "1-16", "issn-l": null}, "abstract": "Governments around the world have issued movement restrictions and quarantines to combat the SARS-CoV-2 (COVID-19) pandemic. However, the Swedish government has not implemented such measures but has depended on individual responsibility. The extent to which individuals have been encouraged to trust in and be satisfied with government strategies and adopt personal health measures, such as social isolation, remains unclear. This study examines the direct effects of trust in the government and risk perception on self-efficacy. Most importantly, this study intends to explore whether satisfaction with government measures strengthens the relationships between 1) trust in the government and self-efficacy and 2) risk perception and self-efficacy. We test our suggested hypotheses using survey data obtained from 403 Swedish citizens living in Sweden. As predicted, the findings indicate that trust in the government and risk perception positively impact individual self-efficacy. Additionally, the findings reveal that satisfaction with government measures strengthens these relationships; more precisely, the impact of trust in the government and risk perception under a high level of individual satisfaction with government measures is much more positive than that under a low satisfaction level. In practice, a focus on implementing successful policies and excellent individual self-efficacy is required to halt the pandemic, and the findings indicate that combining strictly attentive and adaptive individual strategies with government strategies can minimize the spread of infection.", "doi": "10.1007/s12144-022-02947-w", "pmid": "35340688", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "2947"}, {"db": "pmc", "key": "PMC8933660"}], "notes": [], "created": "2022-04-04T06:49:57.235Z", "modified": "2022-04-04T06:49:57.294Z"}, {"entity": "publication", "iuid": "6221bb142023474cbb6069d730245cce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6221bb142023474cbb6069d730245cce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6221bb142023474cbb6069d730245cce"}}, "title": "Small business managers and Covid-19-The role of a sense of coherence and general resistance resources in coping with stressors.", "authors": [{"family": "Hansson", "given": "Josefine", "initials": "J", "orcid": "0000-0001-6385-1556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04f28c63354f4e11b27b8abdab4c58b7.json"}}, {"family": "Landstad", "given": "Bodil J", "initials": "BJ"}, {"family": "Vinberg", "given": "Stig", "initials": "S"}, {"family": "Hedlund", "given": "Marianne", "initials": "M", "orcid": "0000-0002-1789-2477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d8e2939573845109d470f05b8314cee.json"}}, {"family": "Tjulin", "given": "\u00c5sa", "initials": "\u00c5"}], "type": "journal article", "published": "2022-03-18", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "17", "issue": "3", "pages": "e0265029"}, "abstract": "The response of small business managers to an external event such as the pandemic can have a profound effect on the work environment, health and well-being for themselves and their employees. Previous research on small business managers during the pandemic has mainly focused on traditional pathogenic effects, and there is a lack of studies looking at the issue from a salutogenic health promotion perspective. The aim of this study is to explore whether a sense of coherence and general resistance resources were experienced by small business managers in Sweden and Norway during the Covid-19 pandemic.\r\n\r\nA qualitative design was applied through exploratory interviews with 16 managers of small businesses in Sweden and Norway. A content analysis of the interviews was conducted using the sense of coherence concept by Aaron Antonovsky, with the three main components of comprehensibility, meaningfulness and manageability acting as a conceptual framework for the analysis process.\r\n\r\nWithin the three main sense-of-coherence categories, six general resistance resources were identified as being important for the managers to handle uncertainty during the pandemic. These were understanding rules and regulations, social support, optimism, proactivity, problem-solving and flexibility and cooperation.\r\n\r\nThe small business managers handled the pandemic in a way that worked well in their contexts, and the pandemic generally did not have a negative effect on their businesses or themselves. A salutogenic approach, through which the managers focused on identifying and using resources, was an important factor for managing stressors and adversity during the pandemic. Hence, the concept of salutogenesis may be used as an intervention to foster better health in small businesses, both at a personal and organisational level in order to handle future challenges effectively.", "doi": "10.1371/journal.pone.0265029", "pmid": "35302995", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-40328"}, {"db": "pmc", "key": "PMC8932562"}], "notes": [], "created": "2022-04-04T07:20:30.481Z", "modified": "2022-11-22T05:39:10.634Z"}, {"entity": "publication", "iuid": "d40245a393af4e258f8aeb8480b67790", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d40245a393af4e258f8aeb8480b67790.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d40245a393af4e258f8aeb8480b67790"}}, "title": "Associations between hemostatic markers and mortality in COVID-19 - Compounding effects of D-dimer, antithrombin and PAP complex.", "authors": [{"family": "Bokn\u00e4s", "given": "Niklas", "initials": "N"}, {"family": "Laine", "given": "Cia", "initials": "C"}, {"family": "Hillarp", "given": "Andreas", "initials": "A"}, {"family": "Macwan", "given": "Ankit S", "initials": "AS"}, {"family": "Gustafsson", "given": "Kerstin M", "initials": "KM"}, {"family": "Lindahl", "given": "Tomas L", "initials": "TL"}, {"family": "Holmstr\u00f6m", "given": "Margareta", "initials": "M"}], "type": "journal article", "published": "2022-03-18", "journal": {"title": "Thromb Res", "issn": "1879-2472", "volume": "213", "pages": "97-104", "issn-l": "0049-3848"}, "abstract": "In this single-center cohort study, we applied a panel of laboratory markers to characterize hemostatic function in 217 consecutive patients that underwent testing for COVID-19 as they were admitted to Link\u00f6ping University Hospital between April and June 2020. In the 96 patients that tested positive for SARS-CoV-2 (COVID-19+), the cumulative incidences of death and venous thromboembolism were 24.0% and 19.8% as compared to 12.4% (p = 0.031) and 11.6% (p = 0.13) in the 121 patients that tested negative (COVID-19-). In COVID-19+ patients, we found pronounced increases in plasma levels of von Willebrand factor (vWF) and fibrinogen. Excess mortality was observed in COVID-19+ patients with the following aberrations in hemostatic markers: high D-dimer, low antithrombin or low plasmin-antiplasmin complex (PAP) formation, with Odds Ratios (OR) for death of 4.7 (95% confidence interval (CI95) 1.7-12.9; p = 0.003) for D-dimer >0.5 mg/L, 5.9 (CI95 1.8-19.7; p = 0.004) for antithrombin (AT) \u02c20.85 kIU/l and 4.9 (CI95 1.3-18.3; p = 0.019) for PAP < 1000 \u03bcg/L. Compounding increases in mortality was observed in COVID-19+ patients with combined defects in markers of fibrinolysis and coagulation, with ORs for death of 15.7 (CI95 4.3-57; p < 0.001) for patients with PAP <1000 \u03bcg/L and D-dimer >0.5 mg/L and 15.5 (CI95 2.8-87, p = 0.002) for patients with PAP <1000 \u03bcg/L and AT \u02c20.85 kIU/L. We observed an elevated fraction of incompletely degraded D-dimer fragments in COVID-19+ patients with low PAP, indicating impaired fibrinolytic breakdown of cross-linked fibrin.", "doi": "10.1016/j.thromres.2022.03.013", "pmid": "35316719", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0049-3848(22)00090-1"}, {"db": "pmc", "key": "PMC8930184"}], "notes": [], "created": "2022-03-23T06:13:34.273Z", "modified": "2022-04-04T07:11:04.402Z"}, {"entity": "publication", "iuid": "4b29cfb92af74ba9bb0ae2d414a33423", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b29cfb92af74ba9bb0ae2d414a33423.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b29cfb92af74ba9bb0ae2d414a33423"}}, "title": "Digit ratios and their asymmetries as risk factors of developmental instability and hospitalization for COVID-19.", "authors": [{"family": "Kasielska-Trojan", "given": "A", "initials": "A"}, {"family": "Manning", "given": "J T", "initials": "JT"}, {"family": "Jab\u0142kowski", "given": "M", "initials": "M"}, {"family": "Bia\u0142kowska-Warzecha", "given": "J", "initials": "J"}, {"family": "Hirschberg", "given": "A L", "initials": "AL"}, {"family": "Antoszewski", "given": "B", "initials": "B"}], "type": "journal article", "published": "2022-03-17", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "4573", "issn-l": "2045-2322"}, "abstract": "COVID-19 presents with mild symptoms in the majority of patients but in a minority it progresses to acute illness and hospitalization. Here we consider whether markers for prenatal sex hormones and postnatal stressors on developmental instability, i.e. digit ratios and their directional and unsigned asymmetries, are predictive of hospitalization. We focus on six ratios: 2D:3D; 2D:4D; 2D:5D; 3D:4D; 3D:5D; 4D:5D and compare hospitalized patient and control means for right, and left ratios, directional asymmetries (right-left) and unsigned asymmetries [|(right-left)|]. There were 54 patients and 100 controls. We found (i) patients differed in their digit ratios from controls (patients > controls) in all three ratios that included 5D (2D:5D, 3D:5D and 4D:5D) with small to medium effect sizes (d = 0.3 to 0.64), (ii) they did not differ in their directional asymmetries, and (iii) patients had greater |(right-left)| asymmetry than controls for 2D:4D (d = .74) , and all ratios that included 5D; 2D:5D (d = 0.66), 3D:5D (d = .79), 4D:5D (d = 0.47). The Composite Asymmetry of the two largest effects (2D:4D + 3D:5D) gave a patient and control difference with effect size d = 1.04. All patient versus control differences were independent of sex. We conclude that digit ratio patterns differ between patients and controls and this was most evident in ratios that included 5D. Large |(right-left)| asymmetries in the patients are likely to be a marker for postnatal stressors resulting in developmental perturbations and for potential severity of COVID-19.", "doi": "10.1038/s41598-022-08646-7", "pmid": "35301404", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-08646-7"}, {"db": "pmc", "key": "PMC8931101"}], "notes": [], "created": "2022-04-04T07:21:16.821Z", "modified": "2022-04-04T07:21:16.836Z"}, {"entity": "publication", "iuid": "149cb301610f424897b07ab7001e9771", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/149cb301610f424897b07ab7001e9771.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/149cb301610f424897b07ab7001e9771"}}, "title": "Prophylactic anticoagulation with low molecular weight heparin in COVID-19: cohort studies in Denmark and Sweden.", "authors": [{"family": "Lund", "given": "Lars Christian", "initials": "LC"}, {"family": "Hedberg", "given": "Pontus", "initials": "P"}, {"family": "Andreasen", "given": "Anne Helms", "initials": "AH"}, {"family": "Petersen", "given": "Janne", "initials": "J"}, {"family": "Petersen", "given": "Tonny Studsgaard", "initials": "TS"}, {"family": "Potteg\u00e5rd", "given": "Anton", "initials": "A"}, {"family": "Bodilsen", "given": "Jacob", "initials": "J"}, {"family": "Naucler", "given": "Pontus", "initials": "P"}, {"family": "Hallas", "given": "Jesper", "initials": "J"}, {"family": "Jimenez-Solem", "given": "Espen", "initials": "E"}], "type": "journal article", "published": "2022-03-16", "journal": {"title": "Clin Microbiol Infect", "issn": "1469-0691", "issn-l": null}, "abstract": "To evaluate safety and effectiveness of prophylactic anticoagulation with low molecular weight heparin (LMWH) in individuals hospitalised for COVID-19.\n\nUsing healthcare records from the capital region of Denmark (March 2020-February 2021) and Karolinska University Hospital in Sweden (February 2020-September 2021), we conducted an observational cohort study comparing clinical outcomes 30 days after admission among individuals hospitalised for COVID-19 starting prophylactic LMWH during the first 48 hours of hospitalisation with outcomes among those not receiving prophylactic anticoagulation. We used inverse probability weighting to adjust for confounders and bias due to missing information. Risk ratios, risk differences and robust 95% confidence intervals (CI) were estimated using binomial regression. Country-specific risk ratios were pooled using random-effects meta-analysis.\n\nWe included 1692 and 1868 individuals in the Danish and Swedish cohorts. Of these, 771 (46%) and 1167 (62%) received prophylactic LMWH up to 48 hours after admission. The combined mortality in Denmark and Sweden was 12% (N=432) and the pooled risk ratio was 0.89 (CI 0.61-1.29) comparing individuals who received LMWH to those who did not. The relative risk of ICU admission was 1.12 (CI 0.85-1.48), while we observed no increased risk of bleeding (RR 0.60, 0.14-2.59). The relative risk of venous thromboembolism was 0.68 (CI: 0.33-1.38) in Sweden. Less than 5 VTE events were observed among individuals receiving LMWH in Denmark, preventing a meaningful analysis.\n\nWe found no benefit on mortality with prophylactic LMWH and no increased risk of bleeding among COVID-19 patients receiving prophylactic LMWH.", "doi": "10.1016/j.cmi.2022.03.006", "pmid": "35306190", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(22)00145-8"}, {"db": "pmc", "key": "PMC8926439"}], "notes": [], "created": "2022-03-23T06:15:58.305Z", "modified": "2022-04-04T07:11:58.553Z"}, {"entity": "publication", "iuid": "c535676ff3714e12a544dc95d815f7e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c535676ff3714e12a544dc95d815f7e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c535676ff3714e12a544dc95d815f7e7"}}, "title": "Exposure-lag response of air temperature on COVID-19 incidence in twelve Italian cities: A meta-analysis.", "authors": [{"family": "Fong", "given": "Fang Chyi", "initials": "FC"}, {"family": "Smith", "given": "Daniel Robert", "initials": "DR"}], "type": "journal article", "published": "2022-03-16", "journal": {"title": "Environ Res", "issn": "1096-0953", "pages": "113099", "volume": "212", "issue": "Pt A", "issn-l": "0013-9351"}, "abstract": "The exposure-lag response of air temperature on daily COVID-19 incidence is unclear and there have been concerns regarding the robustness of previous studies. Here we present an analysis of high spatial and temporal resolution using the distributed lag non-linear modelling (DLNM) framework. Utilising nearly two years' worth of data, we fit statistical models to twelve Italian cities to quantify the delayed effect of air temperature on daily COVID-19 incidence, accounting for several categories of potential confounders (meteorological, air quality and non-pharmaceutical interventions). Coefficients and covariance matrices for the temperature term were then synthesised using random effects meta-analysis to yield pooled estimates of the exposure-lag response with effects presented as the relative risk (RR) and cumulative RR (RRcum). The cumulative exposure response curve was non-linear, with peak risk at 15.1 \u00b0C and declining risk at progressively lower and higher temperatures. The lowest RRcum at 0.2 \u00b0C is 0.72 [0.56,0.91] times that of the highest risk. Due to this non-linearity, the shape of the lag response curve necessarily varied by temperature. This work suggests that on a given day, air temperature approximately 15 \u00b0C maximises the incidence of COVID-19, with the effects distributed in the subsequent ten days or more.", "doi": "10.1016/j.envres.2022.113099", "pmid": "35305982", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0013-9351(22)00426-1"}, {"db": "pmc", "key": "PMC8925100"}], "notes": [], "created": "2022-03-23T06:16:18.024Z", "modified": "2022-04-04T07:12:12.668Z"}, {"entity": "publication", "iuid": "426e7a01cb93430a878e86cc81edeaf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/426e7a01cb93430a878e86cc81edeaf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/426e7a01cb93430a878e86cc81edeaf3"}}, "title": "Assessing alternative indicators for Covid-19 policy evaluation, with a counterfactual for Sweden.", "authors": [{"family": "Latour", "given": "Chiara", "initials": "C"}, {"family": "Peracchi", "given": "Franco", "initials": "F", "orcid": "0000-0002-4532-6173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b566a37c94d948abbfbe9edc508cc440.json"}}, {"family": "Spagnolo", "given": "Giancarlo", "initials": "G", "orcid": "0000-0003-4117-6283", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd25c165fd0d474d9c6dc385bd27939b.json"}}], "type": "journal article", "published": "2022-03-16", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "3", "pages": "e0264769", "issn-l": "1932-6203"}, "abstract": "Using the synthetic control method, we construct counterfactuals for what would have happened if Sweden had imposed a lockdown during the first wave of the COVID-19 epidemic. We consider eight different indicators, including a novel one that we construct by adjusting recorded daily COVID-19 deaths to account for weakly excess mortality. Correcting for data problems and re-optimizing the synthetic control for each indicator, we find that a lockdown would have had sizable effects within one week. The much longer delay estimated by two previous studies focusing on the number of positives cases is mainly driven by the extremely low testing frequency that prevailed in Sweden in the first months of the epidemic. This result appears relevant for choosing the timing of future lockdowns and highlights the importance of looking at several indicators to derive robust conclusions. We also find that our novel indicator is effective in correcting errors in the COVID-19 deaths series and that the quantitative effects of the lockdown are stronger than previously estimated.", "doi": "10.1371/journal.pone.0264769", "pmid": "35294472", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8926176"}, {"db": "pii", "key": "PONE-D-21-23290"}], "notes": [], "created": "2023-01-13T13:38:34.149Z", "modified": "2023-01-13T13:38:34.233Z"}, {"entity": "publication", "iuid": "cd0e2a2c31544e2496d2efd2a4b773e3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd0e2a2c31544e2496d2efd2a4b773e3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd0e2a2c31544e2496d2efd2a4b773e3"}}, "title": "Application of the SARS-CoV-2-S1 ACE-2 receptor interaction as the basis of the fully automated assay to detect neutralizing SARS-CoV-2-S1 antibodies in blood samples.", "authors": [{"family": "Filchtinski", "given": "Daniel", "initials": "D"}, {"family": "Sundberg", "given": "Magnus", "initials": "M"}, {"family": "Berthold", "given": "Heike", "initials": "H"}, {"family": "Steller", "given": "Laura", "initials": "L"}, {"family": "Kayser", "given": "Jos\u00e9", "initials": "J"}, {"family": "Holz", "given": "Sanja", "initials": "S"}, {"family": "Hinze", "given": "Mario", "initials": "M"}, {"family": "Braeutigam", "given": "Oxana", "initials": "O"}, {"family": "Schulte-Pelkum", "given": "Johannes", "initials": "J"}, {"family": "Fiedler", "given": "Raimund", "initials": "R"}], "type": "journal article", "published": "2022-03-15", "journal": {"title": "J Immunol Methods", "issn": "1872-7905", "volume": "504", "pages": "113258", "issn-l": null}, "abstract": "A quantitative, high throughput, fully automated diagnostic method for the detection of neutralizing anti-SARS-CoV-2 antibodies was developed on the Phadia system based on the interaction of SARS-CoV-2 S1 protein and the human ACE-2 receptor. This method was compared to the current state of the art plaque reduction neutralization test (PRNT) and a high correlation between the two methods was observed. Using a large cohort of blood samples from convalescent patients and controls the method displays very high sensitivity and specificity (99,8% and 99.99%, respectively). Neutralizing antibody titers of mRNA-1273 and BNT162b2-vaccinated persons can also be quantified with this method as well. This fully automated method provides the possibility to determine anti-SARS-CoV-2 neutralizing antibody concentrations in just 2 h.", "doi": "10.1016/j.jim.2022.113258", "pmid": "35304119", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0022-1759(22)00045-X"}, {"db": "pmc", "key": "PMC8923036"}], "notes": [], "created": "2022-04-04T07:19:52.436Z", "modified": "2022-04-04T07:19:52.472Z"}, {"entity": "publication", "iuid": "93c162d21f494e0a9e1a42eda9e6db43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/93c162d21f494e0a9e1a42eda9e6db43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/93c162d21f494e0a9e1a42eda9e6db43"}}, "title": "Structure-based drug repurposing: Traditional and advanced AI/ML-aided methods.", "authors": [{"family": "Choudhury", "given": "Chinmayee", "initials": "C"}, {"family": "Arul Murugan", "given": "N", "initials": "N"}, {"family": "Deva Priyakumar", "given": "U", "initials": "U"}], "type": "journal article", "published": "2022-03-14", "journal": {"title": "Drug Discov Today", "issn": "1878-5832", "issn-l": null}, "abstract": "The current global health emergency in the form of the Coronavirus 2019 (COVID-19) pandemic has highlighted the need for fast, accurate, and efficient drug discovery pipelines. Traditional drug discovery projects relying on in vitro high-throughput screening (HTS) involve large investments and sophisticated experimental set-ups, affordable only to big biopharmaceutical companies. In this scenario, application of efficient state-of-the-art computational methods and modern artificial intelligence (AI)-based algorithms for rapid screening of repurposable chemical space [approved drugs and natural products (NPs) with proven pharmacokinetic profiles] to identify the initial leads is a powerful option to save resources and time. Structure-based drug repurposing is a popular in silico repurposing approach. In this review, we discuss traditional and modern AI-based computational methods and tools applied at various stages for structure-based drug discovery (SBDD) pipelines. Additionally, we highlight the role of generative models in generating molecules with scaffolds from repurposable chemical space.", "doi": "10.1016/j.drudis.2022.03.006", "pmid": "35301148", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1359-6446(22)00112-X"}, {"db": "pmc", "key": "PMC8920090"}], "notes": [], "created": "2022-04-04T07:21:32.874Z", "modified": "2022-04-04T07:21:32.888Z"}, {"entity": "publication", "iuid": "0fc4043c324c449ca2012a1bbf06b59d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0fc4043c324c449ca2012a1bbf06b59d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0fc4043c324c449ca2012a1bbf06b59d"}}, "title": "Inhibition of the main protease of SARS-CoV-2 (Mpro) by repurposing/designing drug-like substances and utilizing nature's toolbox of bioactive compounds.", "authors": [{"family": "Antonopoulou", "given": "Io", "initials": "I"}, {"family": "Sapountzaki", "given": "Eleftheria", "initials": "E"}, {"family": "Rova", "given": "Ulrika", "initials": "U"}, {"family": "Christakopoulos", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2022-03-14", "journal": {"title": "Comput Struct Biotechnol J", "issn": "2001-0370", "volume": "20", "pages": "1306-1344", "issn-l": "2001-0370"}, "abstract": "The emergence of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has resulted in a long pandemic, with numerous cases and victims worldwide and enormous consequences on social and economic life. Although vaccinations have proceeded and provide a valuable shield against the virus, the approved drugs are limited and it is crucial that further ways to combat infection are developed, that can also act against potential mutations. The main protease (Mpro) of the virus is an appealing target for the development of inhibitors, due to its importance in the viral life cycle and its high conservation among different coronaviruses. Several compounds have shown inhibitory potential against Mpro, both in silico and in vitro, with few of them also having entered clinical trials. These candidates include: known drugs that have been repurposed, molecules specifically designed based on the natural substrate of the protease or on structural moieties that have shown high binding affinity to the protease active site, as well as naturally derived compounds, either isolated or in plant extracts. The aim of this work is to collectively present the results of research regarding Mpro inhibitors to date, focusing on the function of the compounds founded by in silico simulations and further explored by in vitro and in vivo assays. Creating an extended portfolio of promising compounds that may block viral replication by inhibiting Mpro and by understanding involved structure-activity relationships, could provide a basis for the development of effective solutions against SARS-CoV-2 and future related outbreaks.", "doi": "10.1016/j.csbj.2022.03.009", "pmid": "35308802", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2001-0370(22)00084-8"}, {"db": "pmc", "key": "PMC8920478"}], "notes": [], "created": "2022-03-23T06:14:41.590Z", "modified": "2022-04-04T07:11:33.427Z"}, {"entity": "publication", "iuid": "b5e110e4d36741ee9862c91028d624df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5e110e4d36741ee9862c91028d624df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5e110e4d36741ee9862c91028d624df"}}, "title": "Natural SARS-CoV-2 Infection Affects Neutralizing Activity in Saliva of Vaccinees.", "authors": [{"family": "Garziano", "given": "Micaela", "initials": "M"}, {"family": "Utyro", "given": "Olga", "initials": "O"}, {"family": "Poliseno", "given": "Mariacristina", "initials": "M"}, {"family": "Santantonio", "given": "Teresa Antonia", "initials": "TA"}, {"family": "Saulle", "given": "Irma", "initials": "I"}, {"family": "Strizzi", "given": "Sergio", "initials": "S"}, {"family": "Lo Caputo", "given": "Sergio", "initials": "S"}, {"family": "Clerici", "given": "Mario", "initials": "M"}, {"family": "Introini", "given": "Andrea", "initials": "A"}, {"family": "Biasin", "given": "Mara", "initials": "M"}], "type": "journal article", "published": "2022-03-11", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "13", "pages": "820250", "issn-l": "1664-3224"}, "abstract": "SARS-CoV-2 transmission mainly occurs through exposure of the upper airway mucosa to infected secretions such as saliva, which are excreted by an infected person. Thus, oral mucosal immunity plays a central role in the prevention of and early defense against SARS-CoV-2 infection. Although virus-specific antibody response has been extensively investigated in blood samples of SARS-CoV-2-infected patients and vaccinees, local humoral immunity in the oral cavity and its relationship to systemic antibody levels needs to be further addressed.\n\nWe fine-tuned a virus neutralization assay (vNTA) to measure the neutralizing activity (NA) of plasma and saliva samples from 20 SARS-CoV-2-infected (SI), 40 SARS-CoV-2-vaccinated (SV), and 28 SARS-CoV-2-vaccinated subjects with a history of infection (SIV) using the \"wild type\" SARS-CoV-2 lineage B.1 (EU) and the Delta (B.1.617.2) strains. To validate the vNTA results, the presence of neutralizing antibodies (NAbs) to the spike receptor binding domain (RBD) was evaluated with an ELISA assay.\n\nNA to SARS-CoV-2 lineage B.1 (EU) was present in plasma samples from all the tested subjects, with higher titers in SIV compared to both SI and SV. Conversely, NA was detected in saliva samples from 10.3% SV, 45% SI, and 92.6% SIV, with significantly lower titers in SV compared to both SI and SIV. The detection of NAbs in saliva reflected its reduced NA in SV.\n\nThe difference in NA of plasma vs. saliva was confirmed in a vNTA where the SARS-CoV-2 B.1 and Delta strains were tested head-to-head, which also revealed a reduced NA of both specimens compared to the B.1 variant.\n\nThe administration of SARS-CoV-2 vaccines was associated with limited virus NA in the oral cavity, as measured in saliva and in comparison to plasma. This difference was more evident in vaccinees without a history of SARS-CoV-2 infection, possibly highlighting the importance of local exposure at the site of virus acquisition to effectively prevent the infection and block its spread. Nevertheless, the presence of immune escape mutations as possibly represented by the SARS-CoV-2 Delta variant negatively affects both local and systemic efficacy of NA associated with vaccination.", "doi": "10.3389/fimmu.2022.820250", "pmid": "35359971", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8962193"}], "notes": [], "created": "2022-04-04T06:33:12.170Z", "modified": "2022-04-04T06:33:12.183Z"}, {"entity": "publication", "iuid": "1baee0c983ad45ff89c7121e577fd912", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1baee0c983ad45ff89c7121e577fd912.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1baee0c983ad45ff89c7121e577fd912"}}, "title": "Experimental Model of Pulmonary Inflammation Induced by SARS-CoV-2 Spike Protein and Endotoxin.", "authors": [{"family": "Puthia", "given": "Manoj", "initials": "M", "orcid": "0000-0001-6048-7234", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9570effdcf284ffdb350c082fc830dac.json"}}, {"family": "Tanner", "given": "Lloyd", "initials": "L"}, {"family": "Petruk", "given": "Ganna", "initials": "G"}, {"family": "Schmidtchen", "given": "Artur", "initials": "A", "orcid": "0000-0001-9209-3141", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/426e00c7c8314ea195f2670af469e19a.json"}}], "type": "journal article", "published": "2022-03-11", "journal": {"title": "ACS Pharmacol. Transl. Sci.", "issn": "2575-9108", "volume": "5", "issue": "3", "pages": "141-148", "issn-l": null}, "abstract": "COVID-19 is characterized by a dysregulated and excessive inflammatory response and, in severe cases, acute respiratory distress syndrome. We have recently demonstrated a previously unknown high-affinity interaction between the SARS-CoV-2 spike (S) protein and bacterial lipopolysaccharide (LPS), leading to the boosting of inflammation. Here we present a mouse inflammation model employing the coadministration of aerosolized S protein together with LPS to the lungs. Using NF-\u03baB-RE-Luc reporter and C57BL/6 mice followed by combinations of bioimaging, cytokine, chemokine, fluorescence-activated cell sorting, and histochemistry analyses, we show that the model yields severe pulmonary inflammation and a cytokine profile similar to that observed in COVID-19. Therefore, the model offers utility for analyses of the pathophysiological features of COVID-19 and the development of new treatments.", "doi": "10.1021/acsptsci.1c00219", "pmid": "35774232", "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9239546"}], "notes": [], "created": "2022-08-17T13:13:35.479Z", "modified": "2022-08-17T13:13:35.592Z"}, {"entity": "publication", "iuid": "5e5f888e68164ea493149edbf81b7f7d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e5f888e68164ea493149edbf81b7f7d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e5f888e68164ea493149edbf81b7f7d"}}, "title": "Efficacy of Adaptogens in Patients with Long COVID-19: A Randomized, Quadruple-Blind, Placebo-Controlled Trial.", "authors": [{"family": "Karosanidze", "given": "Irina", "initials": "I"}, {"family": "Kiladze", "given": "Ushangi", "initials": "U"}, {"family": "Kirtadze", "given": "Nino", "initials": "N"}, {"family": "Giorgadze", "given": "Mikhail", "initials": "M"}, {"family": "Amashukeli", "given": "Nana", "initials": "N"}, {"family": "Parulava", "given": "Nino", "initials": "N"}, {"family": "Iluridze", "given": "Neli", "initials": "N"}, {"family": "Kikabidze", "given": "Nana", "initials": "N"}, {"family": "Gudavadze", "given": "Nana", "initials": "N"}, {"family": "Gelashvili", "given": "Lali", "initials": "L"}, {"family": "Koberidze", "given": "Vazha", "initials": "V"}, {"family": "Gigashvili", "given": "Eka", "initials": "E"}, {"family": "Jajanidze", "given": "Natela", "initials": "N"}, {"family": "Latsabidze", "given": "Naira", "initials": "N"}, {"family": "Mamageishvili", "given": "Nato", "initials": "N"}, {"family": "Shengelia", "given": "Ramaz", "initials": "R"}, {"family": "Hovhannisyan", "given": "Areg", "initials": "A"}, {"family": "Panossian", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8467-4525", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86a40ce1842b4c289c7f09c955ad4325.json"}}], "type": "journal article", "published": "2022-03-11", "journal": {"title": "Pharmaceuticals (Basel)", "issn": "1424-8247", "volume": "15", "issue": "3", "issn-l": null}, "abstract": "Currently, no effective treatment of comorbid complications or COVID-19 long-haulers during convalescence is known. This randomized, quadruple-blind, placebo-controlled trial aimed to assess the efficacy of adaptogens on the recovery of patients with Long COVID symptoms. One hundred patients with confirmed positive SARS-CoV-2 test, discharged from COVID Hotel isolation, Intensive Care Unit (ICU), or Online Clinics, and who experienced at least three of nine Long COVID symptoms (fatigue, headache, respiratory insufficiency, cognitive performance, mood disorders, loss of smell, taste, and hair, sweatiness, cough, pain in joints, muscles, and chest) in the 30 days before randomization were included in the study of the efficacy of Chisan\u00ae/ADAPT-232 (a fixed combination of adaptogens Rhodiola, Eleutherococcus, and Schisandra) supplementation for two weeks. Chisan\u00ae decreased the duration of fatigue and pain for one and two days, respectively, in 50% of patients. The number of patients with lack of fatigue and pain symptoms was significantly less in the Chisan\u00ae treatment group than in the placebo group on Days 9 (39% vs. 57%, pain relief, p = 0.0019) and 11 (28% vs. 43%, relief of fatigue, * p = 0.0157). Significant relief of severity of all Long COVID symptoms over the time of treatment and the follow-up period was observed in both groups of patients, notably decreasing the level of anxiety and depression from mild and moderate to normal, as well as increasing cognitive performance in patients in the d2 test for attention and increasing their physical activity and workout (daily walk time). However, the significant difference between placebo and Chisan\u00ae treatment was observed only with a workout (daily walk time) and relieving respiratory insufficiency (cough). A clinical assessment of blood markers of the inflammatory response (C-reactive protein) and blood coagulation (D-dimer) did not reveal any significant difference over time between treatment groups except significantly lower IL-6 in the Chisan\u00ae treatment group. Furthermore, a significant difference between the placebo and Chisan\u00ae treatment was observed for creatinine: Chisan\u00ae significantly decreased blood creatinine compared to the placebo, suggesting prevention of renal failure progression in Long COVID. In this study, we, for the first time, demonstrate that adaptogens can increase physical performance in Long COVID and reduce the duration of fatigue and chronic pain. It also suggests that Chisan\u00ae/ADAPT-232 might be useful for preventing the progression of renal failure associated with increasing creatinine.", "doi": "10.3390/ph15030345", "pmid": "35337143", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "ph15030345"}, {"db": "pmc", "key": "PMC8953947"}], "notes": [], "created": "2022-04-04T06:51:25.997Z", "modified": "2022-04-04T06:51:26.077Z"}, {"entity": "publication", "iuid": "2e67f1e6d6c64aa2a85ac23ba45946a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e67f1e6d6c64aa2a85ac23ba45946a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e67f1e6d6c64aa2a85ac23ba45946a1"}}, "title": "How the Innate Immune System of the Blood Contributes to Systemic Pathology in COVID-19-Induced ARDS and Provides Potential Targets for Treatment.", "authors": [{"family": "Nilsson", "given": "Bo", "initials": "B"}, {"family": "Persson", "given": "Barbro", "initials": "B"}, {"family": "Eriksson", "given": "Oskar", "initials": "O"}, {"family": "Fromell", "given": "Karin", "initials": "K"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Huber-Lang", "given": "Markus", "initials": "M"}, {"family": "Ekdahl", "given": "Kristina N", "initials": "KN"}], "type": "journal article", "published": "2022-03-08", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "13", "issue": null, "pages": "840137"}, "abstract": "Most SARS-CoV-2 infected patients experience influenza-like symptoms of low or moderate severity. But, already in 2020 early during the pandemic it became obvious that many patients had a high incidence of thrombotic complications, which prompted treatment with high doses of low-molecular-weight heparin (LMWH; typically 150-300IU/kg) to prevent thrombosis. In some patients, the disease aggravated after approximately 10 days and turned into a full-blown acute respiratory distress syndrome (ARDS)-like pulmonary inflammation with endothelialitis, thrombosis and vascular angiogenesis, which often lead to intensive care treatment with ventilator support. This stage of the disease is characterized by dysregulation of cytokines and chemokines, in particular with high IL-6 levels, and also by reduced oxygen saturation, high risk of thrombosis, and signs of severe pulmonary damage with ground glass opacities. The direct link between SARS-CoV-2 and the COVID-19-associated lung injury is not clear. Indirect evidence speaks in favor of a thromboinflammatory reaction, which may be initiated by the virus itself and by infected damaged and/or apoptotic cells. We and others have demonstrated that life-threatening COVID-19 ARDS is associated with a strong activation of the intravascular innate immune system (IIIS). In support of this notion is that activation of the complement and kallikrein/kinin (KK) systems predict survival, the necessity for usage of mechanical ventilation, acute kidney injury and, in the case of MBL, also coagulation system activation with thromboembolism. The general properties of the IIIS can easily be translated into mechanisms of COVID-19 pathophysiology. The prognostic value of complement and KKsystem biomarkers demonstrate that pharmaceuticals, which are licensed or have passed the phase I trial stage are promising candidate drugs for treatment of COVID-19. Examples of such compounds include complement inhibitors AMY-101 and eculizumab (targeting C3 and C5, respectively) as well as kallikrein inhibitors ecallantide and lanadelumab and the bradykinin receptor (BKR) 2 antagonist icatibant. In this conceptual review we discuss the activation, crosstalk and the therapeutic options that are available for regulation of the IIIS.", "doi": "10.3389/fimmu.2022.840137", "pmid": "35350780", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8957861"}], "notes": [], "created": "2022-04-04T06:37:36.306Z", "modified": "2022-08-19T12:35:35.442Z"}, {"entity": "publication", "iuid": "f1049c44123e48d9bf373c9e55a0808c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1049c44123e48d9bf373c9e55a0808c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1049c44123e48d9bf373c9e55a0808c"}}, "title": "Alphacoronavirus in a Daubenton's Myotis Bat (Myotis daubentonii) in Sweden.", "authors": [{"family": "Lwande", "given": "Olivia Wesula", "initials": "OW"}, {"family": "Thalin", "given": "Therese", "initials": "T"}, {"family": "de Jong", "given": "Johnny", "initials": "J"}, {"family": "Sj\u00f6din", "given": "Andreas", "initials": "A", "orcid": "0000-0001-5350-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea9e0de5833a4fb8b1a0039f80d75497.json"}}, {"family": "N\u00e4slund", "given": "Jonas", "initials": "J", "orcid": "0000-0002-4980-913X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6df0e6caa2340bb83bdf02c8fda67d1.json"}}, {"family": "Evander", "given": "Magnus", "initials": "M", "orcid": "0000-0001-6034-4807", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a6d141b52d747d2a63e32e1b2a2ff3d.json"}}, {"family": "Ecke", "given": "Frauke", "initials": "F", "orcid": "0000-0003-4208-345X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2e4af95902b4c45aeb2b0290fe70ebb.json"}}], "type": "journal article", "published": "2022-03-08", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "3", "issn-l": "1999-4915"}, "abstract": "The ongoing COVID-19 pandemic has stimulated a search for reservoirs and species potentially involved in back and forth transmission. Studies have postulated bats as one of the key reservoirs of coronaviruses (CoVs), and different CoVs have been detected in bats. So far, CoVs have not been found in bats in Sweden and we therefore tested whether they carry CoVs. In summer 2020, we sampled a total of 77 adult bats comprising 74 Myotis daubentonii, 2 Pipistrellus pygmaeus, and 1 M. mystacinus bats in southern Sweden. Blood, saliva and feces were sampled, processed and subjected to a virus next-generation sequencing target enrichment protocol. An Alphacoronavirus was detected and sequenced from feces of a M. daubentonii adult female bat. Phylogenetic analysis of the almost complete virus genome revealed a close relationship with Finnish and Danish strains. This was the first finding of a CoV in bats in Sweden, and bats may play a role in the transmission cycle of CoVs in Sweden. Focused and targeted surveillance of CoVs in bats is warranted, with consideration of potential conflicts between public health and nature conservation required as many bat species in Europe are threatened and protected.", "doi": "10.3390/v14030556", "pmid": "35336963", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "v14030556"}, {"db": "pmc", "key": "PMC8953627"}], "notes": [], "created": "2022-04-04T06:51:48.847Z", "modified": "2022-04-04T06:52:01.079Z"}, {"entity": "publication", "iuid": "9af12608a3ea4e4fbf5519d7c128dbe6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9af12608a3ea4e4fbf5519d7c128dbe6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9af12608a3ea4e4fbf5519d7c128dbe6"}}, "title": "The Impact of COVID-19 Confinement on Tinnitus and Hearing Loss in Older Adults: Data From the LOST in Lombardia Study.", "authors": [{"family": "Jarach", "given": "Carlotta Micaela", "initials": "CM"}, {"family": "Lugo", "given": "Alessandra", "initials": "A"}, {"family": "Stival", "given": "Chiara", "initials": "C"}, {"family": "Bosetti", "given": "Cristina", "initials": "C"}, {"family": "Amerio", "given": "Andrea", "initials": "A"}, {"family": "Cavalieri d'Oro", "given": "Luca", "initials": "L"}, {"family": "Iacoviello", "given": "Licia", "initials": "L"}, {"family": "Odone", "given": "Anna", "initials": "A"}, {"family": "Stuckler", "given": "David", "initials": "D"}, {"family": "Zucchi", "given": "Alberto", "initials": "A"}, {"family": "van den Brandt", "given": "Piet", "initials": "P"}, {"family": "Garavello", "given": "Werner", "initials": "W"}, {"family": "Cederroth", "given": "Christopher R", "initials": "CR"}, {"family": "Schlee", "given": "Winfried", "initials": "W"}, {"family": "Gallus", "given": "Silvano", "initials": "S"}, {"family": "LOST in Lombardia Study Investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2022-03-07", "journal": {"title": "Front Neurol", "issn": "1664-2295", "volume": "13", "pages": "838291", "issn-l": null}, "abstract": "Although a direct relationship between tinnitus or hearing difficulties and COVID-19 has been suggested, current literature provides inconsistent results, and no research has been undertaken in older adults.\n\nIn November 2020, we conducted the LOST in Lombardia survey, a telephone-based cross-sectional study on a sample of 4,400 individuals representative of the general population aged \u226565 years from Lombardy region, Northern Italy. Individuals with diagnosed tinnitus and/or hearing loss were asked whether their conditions had improved or deteriorated in 2020 compared to 2019.\n\nOverall, 8.1% of older adults reported a diagnosis of tinnitus and 10.5% of hearing loss. In 2020 compared to 2019, among individuals with tinnitus, those with increasing severity (5.0%) were similar to those decreasing it (5.3%). Among individuals with hearing loss, more people reported an increase (13.6%) than a decrease (3.2%) in their disease severity. No individual with a diagnosis in 2020 of tinnitus (n = 6) or hearing loss (n = 13) had COVID-19. The incidence of tinnitus was lower in 2020 (rate: 14.8 per 10,000 person-years) than in previous years (rate in 1990-2019: 36.0 per 10,000 person-years; p = 0.026). There was no change in the incidence of hearing loss (p = 0.134).\n\nIn this large representative sample of older adults, on average neither COVID-19 confinement nor SARS-CoV-2 infection appeared to increase the severity or incidence of tinnitus. The increased severity of hearing difficulties may totally or partially be explained by physiologic deterioration of the condition, or by a misperception due to the use of face-masks.", "doi": "10.3389/fneur.2022.838291", "pmid": "35330807", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8940241"}], "notes": [], "created": "2022-04-04T06:59:19.890Z", "modified": "2022-04-04T06:59:19.929Z"}, {"entity": "publication", "iuid": "32408591666645588f30bb91a9bc5573", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/32408591666645588f30bb91a9bc5573.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/32408591666645588f30bb91a9bc5573"}}, "title": "Reduced immunogenicity of a third COVID-19 vaccination among recipients of allogeneic haematopoietic stem cell transplantation.", "authors": [{"family": "Einarsdottir", "given": "Sigrun", "initials": "S"}, {"family": "Martner", "given": "Anna", "initials": "A"}, {"family": "Nicklasson", "given": "Malin", "initials": "M"}, {"family": "Wiktorin", "given": "Hanna Grauers", "initials": "HG"}, {"family": "Arabpour", "given": "Mohammad", "initials": "M"}, {"family": "T\u00f6rnell", "given": "Andreas", "initials": "A"}, {"family": "Vaht", "given": "Krista", "initials": "K"}, {"family": "Waldenstr\u00f6m", "given": "Jesper", "initials": "J"}, {"family": "Ringlander", "given": "Johan", "initials": "J"}, {"family": "Bergstr\u00f6m", "given": "Tomas", "initials": "T"}, {"family": "Brune", "given": "Mats", "initials": "M"}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Lagging", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2022-03-03", "journal": {"title": "Haematologica", "issn": "1592-8721", "issn-l": null}, "abstract": "Not available.", "doi": "10.3324/haematol.2021.280494", "pmid": "35236057", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2022-03-04T06:18:44.595Z", "modified": "2022-03-04T06:19:05.660Z"}, {"entity": "publication", "iuid": "d160f1a1ac56447bbc94ec7cb9d00da0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d160f1a1ac56447bbc94ec7cb9d00da0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d160f1a1ac56447bbc94ec7cb9d00da0"}}, "title": "Human serum from SARS-CoV-2-vaccinated and COVID-19 patients shows reduced binding to the RBD of SARS-CoV-2 Omicron variant.", "authors": [{"family": "Schubert", "given": "Maren", "initials": "M", "orcid": "0000-0002-7041-9056", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/896d0278735a4c96b326666b36fd47c3.json"}}, {"family": "Bertoglio", "given": "Federico", "initials": "F", "orcid": "0000-0001-6477-1785", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f9424e832a44ce9b8482a128fbc91ae.json"}}, {"family": "Steinke", "given": "Stephan", "initials": "S", "orcid": "0000-0001-8559-954X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68ea5cf01e194e4383b0844d01e65f08.json"}}, {"family": "Heine", "given": "Philip Alexander", "initials": "PA", "orcid": "0000-0001-9643-6973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/084dfc2bbcb04ca98100923beb096ecb.json"}}, {"family": "Ynga-Durand", "given": "Mario Alberto", "initials": "MA", "orcid": "0000-0002-8586-3993", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bfb80f86d8c4fdabad58bedaea710f6.json"}}, {"family": "Maass", "given": "Henrike", "initials": "H"}, {"family": "Sammartino", "given": "Jos\u00e8 Camilla", "initials": "JC"}, {"family": "Cassaniti", "given": "Irene", "initials": "I"}, {"family": "Zuo", "given": "Fanglei", "initials": "F", "orcid": "0000-0002-4545-1265", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11312f803b4f49d6be77684a634b0caf.json"}}, {"family": "Du", "given": "Likun", "initials": "L", "orcid": "0000-0002-8448-2187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c03c88bf35744aa69ee3569394758ba6.json"}}, {"family": "Korn", "given": "Janin", "initials": "J"}, {"family": "Milo\u0161evi\u0107", "given": "Marko", "initials": "M"}, {"family": "Wenzel", "given": "Esther Veronika", "initials": "EV", "orcid": "0000-0002-6931-5612", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73e24d78e79d4952a3c188b0e8166bd6.json"}}, {"family": "Krstanovi\u0107", "given": "Fran", "initials": "F"}, {"family": "Polten", "given": "Saskia", "initials": "S"}, {"family": "Pribani\u0107-Mate\u0161i\u0107", "given": "Marina", "initials": "M"}, {"family": "Brizi\u0107", "given": "Ilija", "initials": "I"}, {"family": "Baldanti", "given": "Fausto", "initials": "F", "orcid": "0000-0002-3358-8969", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ad31c69d57a43b69e2a4d609d59ab0c.json"}}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "D\u00fcbel", "given": "Stefan", "initials": "S", "orcid": "0000-0001-8811-7390", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fdc38fd876784e20958f659bb25bdde4.json"}}, {"family": "\u0160usti\u0107", "given": "Alan", "initials": "A"}, {"family": "Marcotte", "given": "Harold", "initials": "H", "orcid": "0000-0002-7168-349X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e05b7b044674cc08cd2269ccf8c076e.json"}}, {"family": "Strengert", "given": "Monika", "initials": "M"}, {"family": "Proti\u0107", "given": "Alen", "initials": "A", "orcid": "0000-0002-6573-852X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41668eb51fb64576b6a864e9e7432f1f.json"}}, {"family": "Piralla", "given": "Antonio", "initials": "A"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q", "orcid": "0000-0003-1990-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94a32366862b470eba3a15521b9be290.json"}}, {"family": "\u010ci\u010din-\u0160ain", "given": "Luka", "initials": "L", "orcid": "0000-0003-3978-778X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42fed6a06cbb42b99166b05c15466483.json"}}, {"family": "Hust", "given": "Michael", "initials": "M", "orcid": "0000-0003-3418-6045", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0587ca1111f84a61aaf8917a123d49c1.json"}}], "type": "journal article", "published": "2022-03-03", "journal": {"title": "BMC Med", "issn": "1741-7015", "issn-l": null, "volume": "20", "issue": "1", "pages": "102"}, "abstract": "The COVID-19 pandemic is caused by the betacoronavirus SARS-CoV-2. In November 2021, the Omicron variant was discovered and immediately classified as a variant of concern (VOC), since it shows substantially more mutations in the spike protein than any previous variant, especially in the receptor-binding domain (RBD). We analyzed the binding of the Omicron RBD to the human angiotensin-converting enzyme-2 receptor (ACE2) and the ability of human sera from COVID-19 patients or vaccinees in comparison to Wuhan, Beta, or Delta RBD variants.\r\n\r\nAll RBDs were produced in insect cells. RBD binding to ACE2 was analyzed by ELISA and microscale thermophoresis (MST). Similarly, sera from 27 COVID-19 patients, 81 vaccinated individuals, and 34 booster recipients were titrated by ELISA on RBDs from the original Wuhan strain, Beta, Delta, and Omicron VOCs. In addition, the neutralization efficacy of authentic SARS-CoV-2 wild type (D614G), Delta, and Omicron by sera from 2\u00d7 or 3\u00d7 BNT162b2-vaccinated persons was analyzed.\r\n\r\nSurprisingly, the Omicron RBD showed a somewhat weaker binding to ACE2 compared to Beta and Delta, arguing that improved ACE2 binding is not a likely driver of Omicron evolution. Serum antibody titers were significantly lower against Omicron RBD compared to the original Wuhan strain. A 2.6\u00d7 reduction in Omicron RBD binding was observed for serum of 2\u00d7 BNT162b2-vaccinated persons. Neutralization of Omicron SARS-CoV-2 was completely diminished in our setup.\r\n\r\nThese results indicate an immune escape focused on neutralizing antibodies. Nevertheless, a boost vaccination increased the level of anti-RBD antibodies against Omicron, and neutralization of authentic Omicron SARS-CoV-2 was at least partially restored. This study adds evidence that current vaccination protocols may be less efficient against the Omicron variant.", "doi": "10.1186/s12916-022-02312-5", "pmid": "35236358", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Category: Omicron VoC": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12916-022-02312-5"}], "notes": [], "created": "2022-01-04T15:39:53.792Z", "modified": "2022-03-04T06:16:50.719Z"}, {"entity": "publication", "iuid": "7703dbb65d114688adfed1a169a34cc0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7703dbb65d114688adfed1a169a34cc0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7703dbb65d114688adfed1a169a34cc0"}}, "title": "High seroconversion rate after vaccination with mRNA BNT162b2 vaccine against SARS-CoV-2 among people with HIV - but HIV viremia matters?", "authors": [{"family": "Xu", "given": "Xinling", "initials": "X"}, {"family": "Vesterbacka", "given": "Jan", "initials": "J"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "COVAXID Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-03-01", "journal": {"title": "AIDS", "issn": "1473-5571", "volume": "36", "issue": "3", "pages": "479-481", "issn-l": null}, "abstract": "Our clinical trial of SARS-COV-2 mRNA vaccine in 90 HIV-infected persons on antiviral treatment demonstrated high seroconversion rate and high levels of spike IgG antibodies after two doses of vaccine. The vaccine was well tolerated and not associated with HIV RNA blips. However, the levels of spike IgG antibodies were lower in HIV patients than in healthy controls, especially among those with HIV RNA more than 50 copies/ml at baseline.", "doi": "10.1097/QAD.0000000000003135", "pmid": "35084386", "labels": {"Category: Health": null, "Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "00002030-202203010-00018"}], "notes": [], "created": "2022-01-31T11:46:52.414Z", "modified": "2022-01-31T11:47:42.552Z"}, {"entity": "publication", "iuid": "e2868a3088b7488ba58a50adb64fc094", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2868a3088b7488ba58a50adb64fc094.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2868a3088b7488ba58a50adb64fc094"}}, "title": "Coping with COVID: risk and resilience factors for mental health in a German representative panel study.", "authors": [{"family": "Riepenhausen", "given": "Antje", "initials": "A", "orcid": "0000-0001-8749-5349", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b96a93d2ea914a52bbcad45210d9dec7.json"}}, {"family": "Veer", "given": "Ilya M", "initials": "IM"}, {"family": "Wackerhagen", "given": "Carolin", "initials": "C"}, {"family": "Reppmann", "given": "Zala C", "initials": "ZC"}, {"family": "K\u00f6ber", "given": "G\u00f6ran", "initials": "G"}, {"family": "Ayuso-Mateos", "given": "Jos\u00e9 Luis", "initials": "JL"}, {"family": "B\u00f6gemann", "given": "Sophie A", "initials": "SA"}, {"family": "Corrao", "given": "Giovanni", "initials": "G"}, {"family": "Felez-Nobrega", "given": "Mireia", "initials": "M"}, {"family": "Abad", "given": "Josep Maria Haro", "initials": "JMH"}, {"family": "Hermans", "given": "Erno", "initials": "E"}, {"family": "van Leeuwen", "given": "Judith", "initials": "J"}, {"family": "Lieb", "given": "Klaus", "initials": "K"}, {"family": "Lorant", "given": "Vincent", "initials": "V"}, {"family": "Mary-Krause", "given": "Murielle", "initials": "M"}, {"family": "Mediavilla", "given": "Roberto", "initials": "R"}, {"family": "Melchior", "given": "Maria", "initials": "M"}, {"family": "Mittendorfer-Rutz", "given": "Ellenor", "initials": "E"}, {"family": "Compagnoni", "given": "Matteo Monzio", "initials": "MM", "orcid": "0000-0002-2105-4572", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8008fcd69074d3fa6689539c259716f.json"}}, {"family": "Pan", "given": "Kuan-Yu", "initials": "KY"}, {"family": "Puhlmann", "given": "Lara", "initials": "L"}, {"family": "Roelofs", "given": "Karin", "initials": "K"}, {"family": "Sijbrandij", "given": "Marit", "initials": "M"}, {"family": "Smith", "given": "Pierre", "initials": "P"}, {"family": "T\u00fcscher", "given": "Oliver", "initials": "O"}, {"family": "Witteveen", "given": "Anke", "initials": "A"}, {"family": "Zerban", "given": "Matthias", "initials": "M"}, {"family": "Kalisch", "given": "Raffael", "initials": "R"}, {"family": "Kr\u00f6ger", "given": "Hannes", "initials": "H"}, {"family": "Walter", "given": "Henrik", "initials": "H"}], "type": "journal article", "published": "2022-03-01", "journal": {"title": "Psychol Med", "issn": "1469-8978", "pages": "1-11", "issn-l": "0033-2917"}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic might affect mental health. Data from population-representative panel surveys with multiple waves including pre-COVID data investigating risk and protective factors are still rare.\n\nIn a stratified random sample of the German household population (n = 6684), we conducted survey-weighted multiple linear regressions to determine the association of various psychological risk and protective factors assessed between 2015 and 2020 with changes in psychological distress [(PD; measured via Patient Health Questionnaire for Depression and Anxiety (PHQ-4)] from pre-pandemic (average of 2016 and 2019) to peri-pandemic (both 2020 and 2021) time points. Control analyses on PD change between two pre-pandemic time points (2016 and 2019) were conducted. Regularized regressions were computed to inform on which factors were statistically most influential in the multicollinear setting.\n\nPHQ-4 scores in 2020 (M = 2.45) and 2021 (M = 2.21) were elevated compared to 2019 (M = 1.79). Several risk factors (catastrophizing, neuroticism, and asking for instrumental support) and protective factors (perceived stress recovery, positive reappraisal, and optimism) were identified for the peri-pandemic outcomes. Control analyses revealed that in pre-pandemic times, neuroticism and optimism were predominantly related to PD changes. Regularized regression mostly confirmed the results and highlighted perceived stress recovery as most consistent influential protective factor across peri-pandemic outcomes.\n\nWe identified several psychological risk and protective factors related to PD outcomes during the COVID-19 pandemic. A comparison of pre-pandemic data stresses the relevance of longitudinal assessments to potentially reconcile contradictory findings. Implications and suggestions for targeted prevention and intervention programs during highly stressful times such as pandemics are discussed.", "doi": "10.1017/S0033291722000563", "pmid": "35301966", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0033291722000563"}, {"db": "pmc", "key": "PMC8943230"}], "notes": [], "created": "2022-04-04T07:20:45.813Z", "modified": "2022-04-04T07:20:45.905Z"}, {"entity": "publication", "iuid": "e9b0e6c430d542bdabbe5cdf483f005b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e9b0e6c430d542bdabbe5cdf483f005b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e9b0e6c430d542bdabbe5cdf483f005b"}}, "title": "Trends in alcohol consumption in relation to the COVID-19 pandemic: A cross-country analysis.", "authors": [{"family": "Plata", "given": "Alejandro", "initials": "A"}, {"family": "Motoki", "given": "Kosuke", "initials": "K"}, {"family": "Spence", "given": "Charles", "initials": "C"}, {"family": "Velasco", "given": "Carlos", "initials": "C"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Int J Gastron Food Sci", "issn": "1878-4518", "volume": "27", "pages": "100397", "issn-l": null}, "abstract": "During the first sequence of lockdowns implemented in many countries around the world in early 2020 as a result of the emerging COVID-19 pandemic, there was widespread concern amongst many health professionals regarding a predicted rise in alcohol consumption. However, studies have reported diverse findings, with some consumer groups exhibiting an increase and others a decrease in their alcohol purchase and consumption patterns. Although the long-lasting changes in alcohol consumption, if any, are still unknown, the current situation has effectively accelerated a number of pre-existing trends which will likely continue in the future. E-commerce is growing steadily, mainly because of the restrictions within the on-trade channel and concerns around catching COVID-19 amongst consumers, thus lifting traditional barriers to the adoption of digital channels. Premiumization has also grown significantly during the pandemic, especially in the spirits category, due, in part, to the fact that consumers have been increasingly trying to recreate bar and restaurant quality gastronomic experiences in the privacy of their own homes. The trend toward homemade experiences is multi-stakeholder as consumers, retailers, restaurateurs, bar owners, and brands all try to help facilitate at-home consumption experiences. Larger size purchases seem to reflect not only the stockpiling phenomena that occurred during the initial phases of the pandemic but also convenience for consumers (e.g., avoiding queues). Additionally, the growing home mixology movement has been observed to result in consumers buying larger amounts of alcohol in order to facilitate cocktail making experimentation at home. It is important to stress, though, that this review was specially focused on available data from the first three quarters of 2020, as an effort to identify and understand the initial impacts the COVID-19 was creating amongst alcohol consumers. It currently remains uncertain how these trends will evolve, and whether or not they will continue post COVID-19 (whenever that might be). Key similarities and differences across national markets are highlighted.", "doi": "10.1016/j.ijgfs.2021.100397", "pmid": "35003399", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1878-450X(21)00096-2"}, {"db": "pmc", "key": "PMC8717736"}], "notes": [], "created": "2022-01-13T21:10:53.363Z", "modified": "2022-01-13T21:10:53.401Z"}, {"entity": "publication", "iuid": "f15625c5aebb43d8951a7f1554f20ca1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f15625c5aebb43d8951a7f1554f20ca1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f15625c5aebb43d8951a7f1554f20ca1"}}, "title": "To vote, or not to vote? Electoral campaigns and the spread of COVID-19.", "authors": [{"family": "Cipullo", "given": "Davide", "initials": "D"}, {"family": "Le Moglie", "given": "Marco", "initials": "M"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Eur J Polit Econ", "issn": "0176-2680", "issn-l": null, "volume": "72", "issue": null, "pages": "102118"}, "abstract": "The possibility to run fair electoral campaigns is necessary for the legitimization of modern democracies through elections. Yet, during a pandemic, the risk that electoral campaigns would enhance the spread of the disease is substantive. In this paper, we estimate the causal impact of electoral campaigns on the spread of COVID-19. Exploiting plausibly exogenous variation in the schedule of local elections across Italy, we show that the electoral campaign preceding this latter led to a significant worsening of the epidemiological situation related to the disease. Our results strongly highlight the importance of undertaking stringent measures along the entire electoral process to minimize its epidemiological consequences.", "doi": "10.1016/j.ejpoleco.2021.102118", "pmid": "35317430", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0176-2680(21)00100-2"}, {"db": "pmc", "key": "PMC8931692"}], "notes": [], "created": "2022-04-04T07:10:49.639Z", "modified": "2022-11-22T05:39:27.695Z"}, {"entity": "publication", "iuid": "6dcc84c5565f4f16bc811dc31d81cb4b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6dcc84c5565f4f16bc811dc31d81cb4b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6dcc84c5565f4f16bc811dc31d81cb4b"}}, "title": "The impact of the COVID-19 pandemic on seafarers' mental health and chronic fatigue: Beneficial effects of onboard peer support, external support and Internet access.", "authors": [{"family": "Pauksztat", "given": "Birgit", "initials": "B"}, {"family": "Grech", "given": "Michelle R", "initials": "MR"}, {"family": "Kitada", "given": "Momoko", "initials": "M"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Mar Policy", "issn": "0308-597X", "volume": "137", "pages": "104942", "issn-l": null}, "abstract": "While commercial shipping remained vital for maintaining global supply chains during the COVID-19 pandemic, measures imposed to control the spread of infection have disrupted crew changes and impacted interactions with port personnel and among crew members on board. Initial reports indicate that this affected work and life on board, the length of seafarers' time on board as well as seafarers' employment and family concerns. However, the consequences for seafarers' well-being are not well understood. The purpose of this study was to examine the effects of the COVID-19 pandemic on seafarers' mental health and chronic fatigue, and to analyze the role of potential mitigating factors, notably onboard peer support, external support and Internet quality. Survey responses from 622 seafarers on international commercial vessels were analyzed using structural equation modeling. Findings suggested that the impact of the pandemic increased seafarers' fatigue and mental health problems. However, they also indicated ways of mitigating the negative impact of the pandemic and increasing resilience by enhancing support from fellow crew members on board, ensuring the availability of external support and providing fast and reliable Internet access.", "doi": "10.1016/j.marpol.2021.104942", "pmid": "35013636", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0308-597X(21)00553-4"}, {"db": "pmc", "key": "PMC8732879"}], "notes": [], "created": "2022-01-13T21:04:46.083Z", "modified": "2022-01-13T21:04:46.121Z"}, {"entity": "publication", "iuid": "29f0d487451f4f468291855f641a3944", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/29f0d487451f4f468291855f641a3944.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/29f0d487451f4f468291855f641a3944"}}, "title": "Risk of severe COVID-19 from the Delta and Omicron variants in relation to vaccination status, sex, age and comorbidities - surveillance results from southern Sweden, July 2021 to January 2022.", "authors": [{"family": "Kahn", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-5566-6350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42eda71f3775400599febc10a4e7359c.json"}}, {"family": "Bonander", "given": "Carl", "initials": "C", "orcid": "0000-0002-1189-9950", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/386ac82b1a4843828b503ec807c08206.json"}}, {"family": "Moghaddassi", "given": "Mahnaz", "initials": "M", "orcid": "0000-0002-0844-4736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a219bde5ba8a4f3f8655ada08d749885.json"}}, {"family": "Rasmussen", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1588-5473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c760e8d21ae441ba236f86e6185d392.json"}}, {"family": "Malmqvist", "given": "Ulf", "initials": "U"}, {"family": "Inghammar", "given": "Malin", "initials": "M", "orcid": "0000-0003-2995-1312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4ab710428614cccb2a537ecab31d0a0.json"}}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J", "orcid": "0000-0003-1883-2000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e88fdca336ae41c891f0a46e2481b67f.json"}}], "type": "journal article", "published": "2022-03-00", "journal": {"issn": "1560-7917", "volume": "27", "issue": "9", "title": "Euro Surveill", "issn-l": null}, "abstract": "We compared the risk of severe COVID-19 during two periods 2021 and 2022 when Delta and Omicron, respectively, were the dominating virus variants in Scania county, Sweden. We adjusted for differences in sex, age, comorbidities, prior infection and vaccination. Risk of severe disease from Omicron was markedly lower among vaccinated cases. It was also lower among the unvaccinated but remained high (> 5%) for older people and middle-aged men with two or more comorbidities. Efforts to increase vaccination uptake should continue.", "doi": "10.2807/1560-7917.ES.2022.27.9.2200121", "pmid": "35241215", "labels": {"Category: Health": null, "Category: Omicron VoC": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8895467"}], "notes": [], "created": "2022-03-04T12:16:55.501Z", "modified": "2023-01-13T13:29:15.838Z"}, {"entity": "publication", "iuid": "ced6307812f3447f90283e6d7a76ed1b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ced6307812f3447f90283e6d7a76ed1b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ced6307812f3447f90283e6d7a76ed1b"}}, "title": "Risk factors associated with an outbreak of COVID-19 in a meat processing plant in southern Germany, April to June 2020.", "authors": [{"family": "Finci", "given": "Iris", "initials": "I"}, {"family": "Siebenbaum", "given": "Remo", "initials": "R"}, {"family": "Richtzenhain", "given": "Josephin", "initials": "J"}, {"family": "Edwards", "given": "Angelika", "initials": "A"}, {"family": "Rau", "given": "Carina", "initials": "C"}, {"family": "Ehrhardt", "given": "Jonas", "initials": "J"}, {"family": "Koiou", "given": "Linda", "initials": "L"}, {"family": "Joggerst", "given": "Brigitte", "initials": "B"}, {"family": "Brockmann", "given": "Stefan O", "initials": "SO"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "27", "issue": "13", "issn-l": null}, "abstract": "Meat processing plants have been prominent hotspots for coronavirus disease (COVID-19) outbreaks around the world. We describe infection prevention measures and risk factors for infection spread at a meat processing plant in Germany with a COVID-19 outbreak from April to June 2020. We analysed a cohort of all employees and defined cases as employees with either a PCR or ELISA positive result. Of 1,270 employees, 453 (36%) had evidence of SARS-CoV-2 infection. The highest attack rates were observed in meat processing and slaughtering areas. Multivariable analysis revealed that being a subcontracted employee (adjusted risk ratio (aRR)): 1.43, 95% CI: 1.06-1.96), working in the meat cutting area (aRR: 2.44, 95% CI: 1.45-4.48), working in the slaughtering area (aRR: 2.35, 95% CI: 1.32-4.45) and being a veterinary inspector (aRR: 4.77, 95% CI: 1.16-23.68) increased infection risk. Sharing accommodation or transportation were not identified as risk factors for infection. Our results suggest that workplace was the main risk factor for infection spread. These results highlight the importance of implementing preventive measures targeting meat processing plants. Face masks, distancing, staggering breaks, increased hygiene and regular testing for SARS-CoV2 helped limit this outbreak, as the plant remained open throughout the outbreak.", "doi": "10.2807/1560-7917.ES.2022.27.13.2100354", "pmid": "35362409", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-04-04T06:26:04.791Z", "modified": "2022-04-04T06:32:06.397Z"}, {"entity": "publication", "iuid": "fbc972343a6d4cd5a996f6174fb380bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fbc972343a6d4cd5a996f6174fb380bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fbc972343a6d4cd5a996f6174fb380bf"}}, "title": "Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19.", "authors": [{"family": "Palmos", "given": "Alish B", "initials": "AB", "orcid": "0000-0001-5748-6652", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dcc29f88bdd44f679b0627ecde4b1369.json"}}, {"family": "Millischer", "given": "Vincent", "initials": "V", "orcid": "0000-0003-1919-9649", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fc3992e3cd045169e4b45e55e621071.json"}}, {"family": "Menon", "given": "David K", "initials": "DK", "orcid": "0000-0002-3228-9692", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a9033d3171140c696fcb18b9983ac2e.json"}}, {"family": "Nicholson", "given": "Timothy R", "initials": "TR", "orcid": "0000-0002-2350-2332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bd53b4c7f1a4b2a853fcefc53184111.json"}}, {"family": "Taams", "given": "Leonie S", "initials": "LS"}, {"family": "Michael", "given": "Benedict", "initials": "B", "orcid": "0000-0002-8693-8926", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d0bd491219e64319aef1794f6ae1761e.json"}}, {"family": "Sunderland", "given": "Geraint", "initials": "G", "orcid": "0000-0001-9040-5949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6fcce9323d74d719807117806217c46.json"}}, {"family": "Griffiths", "given": "Michael J", "initials": "MJ"}, {"family": "COVID Clinical Neuroscience Study Consortium", "given": "", "initials": ""}, {"family": "H\u00fcbel", "given": "Christopher", "initials": "C"}, {"family": "Breen", "given": "Gerome", "initials": "G"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "PLoS Genet", "issn": "1553-7404", "volume": "18", "issue": "3", "pages": "e1010042", "issn-l": null}, "abstract": "In November 2021, the COVID-19 pandemic death toll surpassed five million individuals. We applied Mendelian randomization including >3,000 blood proteins as exposures to identify potential biomarkers that may indicate risk for hospitalization or need for respiratory support or death due to COVID-19, respectively. After multiple testing correction, using genetic instruments and under the assumptions of Mendelian Randomization, our results were consistent with higher blood levels of five proteins GCNT4, CD207, RAB14, C1GALT1C1, and ABO being causally associated with an increased risk of hospitalization or respiratory support/death due to COVID-19 (ORs = 1.12-1.35). Higher levels of FAAH2 were solely associated with an increased risk of hospitalization (OR = 1.19). On the contrary, higher levels of SELL, SELE, and PECAM-1 decrease risk of hospitalization or need for respiratory support/death (ORs = 0.80-0.91). Higher levels of LCTL, SFTPD, KEL, and ATP2A3 were solely associated with a decreased risk of hospitalization (ORs = 0.86-0.93), whilst higher levels of ICAM-1 were solely associated with a decreased risk of respiratory support/death of COVID-19 (OR = 0.84). Our findings implicate blood group markers and binding proteins in both hospitalization and need for respiratory support/death. They, additionally, suggest that higher levels of endocannabinoid enzymes may increase the risk of hospitalization. Our research replicates findings of blood markers previously associated with COVID-19 and prioritises additional blood markers for risk prediction of severe forms of COVID-19. Furthermore, we pinpoint druggable targets potentially implicated in disease pathology.", "doi": "10.1371/journal.pgen.1010042", "pmid": "35239653", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "PGENETICS-D-21-01126"}], "notes": [], "created": "2022-03-04T06:17:49.932Z", "modified": "2022-03-04T06:18:03.322Z"}, {"entity": "publication", "iuid": "e4fb546c8a6f42708ca685bfc253704a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e4fb546c8a6f42708ca685bfc253704a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e4fb546c8a6f42708ca685bfc253704a"}}, "title": "Nowcasting (Short-Term Forecasting) of COVID-19 Hospitalizations Using Syndromic Healthcare Data, Sweden, 2020.", "authors": [{"family": "Spreco", "given": "Armin", "initials": "A"}, {"family": "J\u00f6ud", "given": "Anna", "initials": "A", "orcid": "0000-0001-7192-4911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e038a5ce2f5a47bd89e7c221651a3d24.json"}}, {"family": "Eriksson", "given": "Olle", "initials": "O"}, {"family": "Soltesz", "given": "Kristian", "initials": "K"}, {"family": "K\u00e4llstr\u00f6m", "given": "Reidar", "initials": "R"}, {"family": "Dahlstr\u00f6m", "given": "\u00d6rjan", "initials": "\u00d6"}, {"family": "Eriksson", "given": "Henrik", "initials": "H"}, {"family": "Ekberg", "given": "Joakim", "initials": "J"}, {"family": "Jonson", "given": "Carl-Oscar", "initials": "CO"}, {"family": "Fraenkel", "given": "Carl-Johan", "initials": "CJ"}, {"family": "Lundh", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Gerlee", "given": "Philip", "initials": "P", "orcid": "0000-0001-8503-0177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ba426c1ab741e781d2b9cd09a0b830.json"}}, {"family": "Gustafsson", "given": "Fredrik", "initials": "F"}, {"family": "Timpka", "given": "Toomas", "initials": "T"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Emerg Infect Dis", "issn": "1080-6059", "volume": "28", "issue": "3", "pages": "564-571", "issn-l": null}, "abstract": "We report on local nowcasting (short-term forecasting) of coronavirus disease (COVID-19) hospitalizations based on syndromic (symptom) data recorded in regular healthcare routines in \u00d6sterg\u00f6tland County (population \u2248465,000), Sweden, early in the pandemic, when broad laboratory testing was unavailable. Daily nowcasts were supplied to the local healthcare management based on analyses of the time lag between telenursing calls with the chief complaints (cough by adult or fever by adult) and COVID-19 hospitalization. The complaint cough by adult showed satisfactory performance (Pearson correlation coefficient r>0.80; mean absolute percentage error <20%) in nowcasting the incidence of daily COVID-19 hospitalizations 14 days in advance until the incidence decreased to <1.5/100,000 population, whereas the corresponding performance for fever by adult was unsatisfactory. Our results support local nowcasting of hospitalizations on the basis of symptom data recorded in routine healthcare during the initial stage of a pandemic.", "doi": "10.3201/eid2803.210267", "pmid": "35201737", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8888224"}], "notes": [], "created": "2023-01-13T13:40:49.234Z", "modified": "2023-06-19T14:58:56.435Z"}, {"entity": "publication", "iuid": "6dff0f71c8d54791be1886456cb3fcd2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6dff0f71c8d54791be1886456cb3fcd2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6dff0f71c8d54791be1886456cb3fcd2"}}, "title": "Inequitable impact of infection: social gradients in severe COVID-19 outcomes among all confirmed SARS-CoV-2 cases during the first pandemic wave in Sweden.", "authors": [{"family": "Gustafsson", "given": "Per E", "initials": "PE", "orcid": "0000-0002-3972-5362", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9ac282ae534432f9e8135a8070683bc.json"}}, {"family": "San Sebastian", "given": "Miguel", "initials": "M"}, {"family": "Fonseca-Rodriguez", "given": "Osvaldo", "initials": "O", "orcid": "0000-0002-0253-5928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52ff35d4b27c4150984ca0428976d442.json"}}, {"family": "Fors Connolly", "given": "Anne-Marie", "initials": "AM"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "J Epidemiol Community Health", "issn": "1470-2738", "issn-l": null, "volume": "76", "issue": "3", "pages": "261-267"}, "abstract": "The backdrop of the ubiquitous social inequalities has increasingly come into foreground in research on the COVID-19 pandemic, but the lack of high-quality population-based studies limits our understanding of the inequitable outcomes of the disease. The present study seeks to estimate social gradients in COVID-19 hospitalisations, intensive care admissions and death by education, income and country of birth, while taking into account disparities in comorbidities.\n\nWe used a register-based retrospective open cohort design enrolling all 74 659 confirmed SARS-CoV-2-positive cases aged >25 years in Sweden during the first wave of the pandemic (until 14 September 2020). Information was retrieved from multiple registers and linked by the unique Swedish personal identity number concerning COVID-19 case identification; COVID-19 hospitalisations, intensive care admissions and death; comorbidities as measured by the Charlson Comorbidity Index; and sociodemographic information. Social gradients were estimated by the Relative Index of Inequality (RII) using Cox regression.\n\nAdjusted analyses showed significant social gradients in COVID-19 hospitalisation, intensive care admission, across education, income and country of birth, which were unaffected by adjustment for comorbidities. Education and country of birth gradients were stronger for hospitalisation and intensive care admissions but small to non-existent for death. In contrast, income gradients were consistent across all three COVID-19 outcomes.\n\nSocial gradients in severe COVID-19 outcomes are widespread in Sweden, but appear to be unrelated to pre-existing health disparities. Inequitable outcomes of SARS-CoV-2 infection may therefore be at least partially avoidable and could rely on equitable management of confirmed COVID-19 cases.", "doi": "10.1136/jech-2021-216778", "pmid": "34526373", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8449839"}, {"db": "pii", "key": "jech-2021-216778"}], "notes": [], "created": "2021-09-20T16:49:45.287Z", "modified": "2023-01-13T13:54:20.184Z"}, {"entity": "publication", "iuid": "54b72a2f5d5d4388bf593a0fbc1bbaa5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54b72a2f5d5d4388bf593a0fbc1bbaa5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54b72a2f5d5d4388bf593a0fbc1bbaa5"}}, "title": "Impact of COVID-19 on adolescent travel behavior.", "authors": [{"family": "Liu", "given": "Jianrong", "initials": "J"}, {"family": "Cao", "given": "Qiongwen", "initials": "Q"}, {"family": "Pei", "given": "Mingyang", "initials": "M"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "J Transp Health", "issn": "2214-1405", "volume": "24", "pages": "101326", "issn-l": null}, "abstract": "The outbreak of COVID-19 has significantly impacted travel behavior. However, few studies have analyzed the impact of COVID-19 on adolescent travel behavior. This article analyzed the impact of COVID-19 on adolescent travel behavior using questionnaire survey data.\n\nThis paper first used confirmatory factor analysis (CFA) to explore the psychological factors related to the adolescents' perceptions about the severity of COVID-19. The study then established a logit model to study the effects of COVID-19 in different phases (before, during, and after the epidemic peak), demographic characteristics, and the role of psychological factors on their travel behavior.\n\nThe results show that the phase of COVID-19 did not significantly impact the adolescents' choice of short-distance travel. The frequency of outings per week, the number of exercise sessions per week, and willingness to travel by public transportation decreased significantly in the outbreak phase. Meanwhile, the perception of the severity of COVID-19 significantly impacted adolescent travel behavior.\n\nThis research demonstrates that COVID-19 has led adolescents to reduce their frequency of outings, and they try not to use public transportation. Adolescents appear to be traveling more cautiously in the outbreak phase and the post-epidemic phase.", "doi": "10.1016/j.jth.2021.101326", "pmid": "35013706", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2214-1405(21)00356-X"}, {"db": "pmc", "key": "PMC8730543"}], "notes": [], "created": "2022-01-13T21:04:28.715Z", "modified": "2022-01-13T21:04:28.749Z"}, {"entity": "publication", "iuid": "69ee238aa92f414db1e2f921762e76eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69ee238aa92f414db1e2f921762e76eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69ee238aa92f414db1e2f921762e76eb"}}, "title": "Ethics framework and recommendations to support capabilities of people with intellectual and developmental disabilities during pandemics.", "authors": [{"family": "Sullivan", "given": "William F", "initials": "WF", "orcid": "0000-0002-0520-0541", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e747cb9cd7f3443e8ef4432fc6204ca2.json"}}, {"family": "Bj\u00f6rne", "given": "Petra", "initials": "P", "orcid": "0000-0001-8085-2008", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/226848f597ca496cacf85b62ba73886c.json"}}, {"family": "Heng", "given": "John", "initials": "J", "orcid": "0000-0002-6080-580X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a04c6d3b0274883b6221f74dfd88eb9.json"}}, {"family": "Northway", "given": "Ruth", "initials": "R"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "J Policy Pract Intellect Disabil", "issn": "1741-1122", "volume": "19", "issue": "1", "pages": "116-124", "issn-l": null}, "abstract": "A growing body of knowledge highlights the negative impact of the COVID-19 pandemic on the health and well-being of many people with intellectual and developmental disabilities (IDDs) and their caregivers. The underlying reasons are not only due to biomedical factors but also ethical issues. They stem from longstanding and pervasive structural injustices and negative social attitudes that continue to devalue people with IDD and that underlie certain clinical decisions and frameworks for public-health policies during this pandemic. Unless these fundamental ethical shortcomings are addressed, pandemic responses will continue to undermine the human rights and well-being of people with IDD. This paper proposes an ethics framing for policy and practices regarding clinical care and public health based on Martha Nussbaum's approach to Capability Theory. Such a framework can reorient healthcare professionals and healthcare systems to support the capabilities of people with IDD to protect, recover, and promote health and well-being. It could be applied during this pandemic and in planning for future pandemics. The paper presents some practical recommendations that follow from applying this framework.", "doi": "10.1111/jppi.12413", "pmid": "35601010", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "JPPI12413"}, {"db": "pmc", "key": "PMC9115164"}], "notes": [], "created": "2022-06-21T17:56:57.068Z", "modified": "2022-06-21T17:56:57.217Z"}, {"entity": "publication", "iuid": "639c6314592045dbbc3fb5b75de89134", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/639c6314592045dbbc3fb5b75de89134.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/639c6314592045dbbc3fb5b75de89134"}}, "title": "Detection and isolation of airborne SARS-CoV-2 in a hospital setting.", "authors": [{"family": "Rufino de Sousa", "given": "Nuno", "initials": "N", "orcid": "0000-0002-0670-9788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1cb037a9e7f44a489dd84d6f5ba513d7.json"}}, {"family": "Steponaviciute", "given": "Laura", "initials": "L"}, {"family": "Margerie", "given": "Lucille", "initials": "L", "orcid": "0000-0001-9537-1231", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e7015e5251242ecb70df112f997182b.json"}}, {"family": "Nissen", "given": "Karolina", "initials": "K"}, {"family": "Kjellin", "given": "Midori", "initials": "M", "orcid": "0000-0002-1377-6014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cbf761ec44641a5a70ee1b8f7964a20.json"}}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Salaneck", "given": "Erik", "initials": "E"}, {"family": "Udekwu", "given": "Klas I", "initials": "KI"}, {"family": "Rothfuchs", "given": "Antonio Gigliotti", "initials": "AG", "orcid": "0000-0001-6001-7240", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00102c49ae2d41828272e850cd551c9f.json"}}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Indoor Air", "issn": "0905-6947", "volume": "32", "issue": "3", "pages": "e13023", "issn-l": null}, "abstract": "Transmission mechanisms for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are incompletely understood. In particular, aerosol transmission remains unclear, with viral detection in air and demonstration of its infection potential being actively investigated. To this end, we employed a novel electrostatic collector to sample air from rooms occupied by COVID-19 patients in a major Swedish hospital. Electrostatic air sampling in conjunction with extraction-free, reverse-transcriptase polymerase chain reaction (hid-RT-PCR) enabled detection of SARS-CoV-2 in air from patient rooms (9/22; 41%) and adjoining anterooms (10/22; 45%). Detection with hid-RT-PCR was concomitant with viral RNA presence on the surface of exhaust ventilation channels in patients and anterooms more than 2 m from the COVID-19 patient. Importantly, it was possible to detect active SARS-CoV-2 particles from room air, with a total of 496 plaque-forming units (PFUs) being isolated, establishing the presence of infectious, airborne SARS-CoV-2 in rooms occupied by COVID-19 patients. Our results support circulation of SARS-CoV-2 via aerosols and urge the revision of existing infection control frameworks to include airborne transmission.", "doi": "10.1111/ina.13023", "pmid": "35347788", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null, "Research Area: Pandemic preparedness": null, "Funder: KAW/SciLifeLab": null, "Category: Other": null, "Research Area: Diagnostics for virus": null}, "xrefs": [], "notes": [], "created": "2022-03-29T15:54:03.910Z", "modified": "2022-04-04T06:43:36.321Z"}, {"entity": "publication", "iuid": "53b1f06a77394293a23a2f053f38c850", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53b1f06a77394293a23a2f053f38c850.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53b1f06a77394293a23a2f053f38c850"}}, "title": "Consultations with health care providers and use of self-management strategies for prevention and treatment of COVID-19 related symptoms. A population based cross-sectional study in Norway, Sweden and the Netherlands.", "authors": [{"family": "Kristoffersen", "given": "Agnete E", "initials": "AE"}, {"family": "van der Werf", "given": "Esther T", "initials": "ET"}, {"family": "Stub", "given": "Trine", "initials": "T"}, {"family": "Musial", "given": "Frauke", "initials": "F"}, {"family": "Wider", "given": "Barbara", "initials": "B"}, {"family": "Jong", "given": "Miek C", "initials": "MC"}, {"family": "Wode", "given": "Kathrin", "initials": "K"}, {"family": "Danell", "given": "Jenny-Ann B", "initials": "JB"}, {"family": "Busch", "given": "Martine", "initials": "M"}, {"family": "Hoenders", "given": "H J Rogier", "initials": "HJR"}, {"family": "Nordberg", "given": "Johanna H", "initials": "JH"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Complement Ther Med", "issn": "1873-6963", "volume": "64", "pages": "102792", "issn-l": null}, "abstract": "The present study was initiated to determine consultations with health care providers and use of self-management strategies for prevention or treatment of COVID-19 related symptoms in countries with a full lockdown (Norway), a partial lockdown (the Netherlands) and no lockdown (Sweden) during the first three months of the COVID-19 pandemic, and if such use correlates with worries of being infected by COVID-19 disease.\n\nData were collected in collaboration with Ipsos A/S in April-June 2020. An adapted version of the International Questionnaire to measure use of Complementary and Alternative Medicine (I-CAM-Q) was used with the categories \"for prevention of COVID-19\" and \"to treat COVID-19-related symptoms\" added. Data were collected among a representative sample in Norway, Sweden and the Netherlands using data assisted telephone interviews (Norway, n=990 and Sweden, n=500), and an online survey (the Netherlands, n=1004). Total response rate was 30%.\n\nVery few consulted a health care provider with the intention to treat or prevent COVID-19 (1.2% and 1.0% respectively) with medical doctors mostly visited (1.0% and 0.9% respectively). Similarly, the use of self-management strategies to prevent or treat COVID-19 was low (3.4% and 0.2% respectively); most commonly used for prevention of COVID-19 were vitamins and minerals (2.8%). Consultations with health care providers and use of self-management strategies for prevention of COVID-19 were positively associated with worries of being infected with COVID-19.\n\nThe COVID-19 pandemic does not seem to have evoked a large-scale difference in behavior related to consultations with health care providers or the use of self-management strategies in any of the three countries.", "doi": "10.1016/j.ctim.2021.102792", "pmid": "34826590", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8609665"}, {"db": "pii", "key": "S0965-2299(21)00133-3"}], "notes": [], "created": "2021-12-18T18:18:07.845Z", "modified": "2023-01-13T13:50:24.202Z"}, {"entity": "publication", "iuid": "611e7570be744b3e9fcc1ac31c571e7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/611e7570be744b3e9fcc1ac31c571e7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/611e7570be744b3e9fcc1ac31c571e7e"}}, "title": "In-Flight Transmission of a SARS-CoV-2 Lineage B.1.617.2 Harbouring the Rare S:E484Q Immune Escape Mutation.", "authors": [{"family": "Martinell", "given": "Mats", "initials": "M"}, {"family": "Andersson", "given": "Tanja", "initials": "T"}, {"family": "Mannsverk", "given": "Steinar Sm\u00f8rholm", "initials": "SS"}, {"family": "Bergholm", "given": "Julia", "initials": "J"}, {"family": "Ellstr\u00f6m", "given": "Patrik", "initials": "P"}, {"family": "Hill", "given": "Anna", "initials": "A"}, {"family": "Lindh", "given": "Johan", "initials": "J"}, {"family": "Kaden", "given": "Rene", "initials": "R", "orcid": "0000-0002-2111-9751", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2be6374ef0bf4ba39e5f5dbbb059747f.json"}}], "type": "journal article", "published": "2022-02-28", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "3", "issn-l": "1999-4915"}, "abstract": "We describe a flight-associated infection scenario of seven individuals with a B.1.617.2 (Delta) lineage, harbouring an S:E484Q point mutation. In Sweden, at least 10% of all positive SARS-CoV-2 samples were sequenced in each county; the B.1.717.2 + S:E484Q combination was not detected in Sweden before and was imported within the scenario described in this report. The high transmission rate of the delta lineage combined with the S:E484Q mutation, associated with immune escape in other lineages, makes this specific genetic combination a possible threat to the global fight against the COVID-19 pandemic. Even within the Omicron wave, the B.1.617.2 + S:E484Q variant appeared in community samples in Sweden, as it seems that this combination has an evolutionary gain compared to other B.1.617.2 lineages. The here described genomic combination was not detectable with the common fasta file-based Pango-lineage analysis, hence increasing the probability of the true global prevalence to be higher.", "doi": "10.3390/v14030504", "pmid": "35336908", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "v14030504"}, {"db": "pmc", "key": "PMC8953675"}], "notes": [], "created": "2022-03-28T16:42:05.248Z", "modified": "2022-04-04T06:52:20.339Z"}, {"entity": "publication", "iuid": "0da027ce656c4236937fd53d3ff32362", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0da027ce656c4236937fd53d3ff32362.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0da027ce656c4236937fd53d3ff32362"}}, "title": "Short-term improvement of mental health after a COVID-19 vaccination", "authors": [{"family": "Chourpiliadis", "given": "Charilaos", "initials": "C", "orcid": "0000-0002-4733-5698", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60f9cb9172274531bc75c430eeb74a31.json"}}, {"family": "Lovik", "given": "Anik\u00f3", "initials": "A", "orcid": "0000-0002-6397-5011", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e50d5a79a1234cd79b22ec2eebf6f410.json"}}, {"family": "K\u00e4hler", "given": "Anna K", "initials": "AK", "orcid": "0000-0003-4047-4588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6d52ec01645417eb73e2bfe6c3106bd.json"}}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA", "orcid": "0000-0001-5382-946X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87d1dbec7c6f4942b1db2b999eeb9ece.json"}}, {"family": "Frans", "given": "Emma M", "initials": "EM", "orcid": "0000-0002-9791-687X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/157f412416124221ab8387bfaee3b75b.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF", "orcid": "0000-0002-6619-873X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f9632d685f348cea7a69ebfe51ad0ab.json"}}, {"family": "Fang", "given": "Fang", "initials": "F", "orcid": "0000-0002-3310-6456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b0852465cd14239a25329b976172792.json"}}], "type": "posted-content", "published": "2022-02-27", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.02.22.22271327", "pmid": null, "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Preprint": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-02-13T18:39:58.873Z", "modified": "2023-02-13T18:40:15.895Z"}, {"entity": "publication", "iuid": "45f65fcb21a545e79c2083314dda7609", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/45f65fcb21a545e79c2083314dda7609.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/45f65fcb21a545e79c2083314dda7609"}}, "title": "Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line.", "authors": [{"family": "Ald\u00e9n", "given": "Markus", "initials": "M", "orcid": "0000-0002-5166-0055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb334111adf44509a04451a8d3b36483.json"}}, {"family": "Olofsson Falla", "given": "Francisko", "initials": "F"}, {"family": "Yang", "given": "Daowei", "initials": "D"}, {"family": "Barghouth", "given": "Mohammad", "initials": "M"}, {"family": "Luan", "given": "Cheng", "initials": "C"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}, {"family": "De Marinis", "given": "Yang", "initials": "Y", "orcid": "0000-0002-8081-2142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c85c6f6e14a44415a2bea1cfe224e50c.json"}}], "type": "journal article", "published": "2022-02-25", "journal": {"title": "CIMB", "issn": "1467-3045", "volume": "44", "issue": "3", "pages": "1115-1126", "issn-l": null}, "abstract": "Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 injection. Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of human cells. In this study, we investigated the effect of BNT162b2 on the human liver cell line Huh7 in vitro. Huh7 cells were exposed to BNT162b2, and quantitative PCR was performed on RNA extracted from the cells. We detected high levels of BNT162b2 in Huh7 cells and changes in gene expression of long interspersed nuclear element-1 (LINE-1), which is an endogenous reverse transcriptase. Immunohistochemistry using antibody binding to LINE-1 open reading frame-1 RNA-binding protein (ORFp1) on Huh7 cells treated with BNT162b2 indicated increased nucleus distribution of LINE-1. PCR on genomic DNA of Huh7 cells exposed to BNT162b2 amplified the DNA sequence unique to BNT162b2. Our results indicate a fast up-take of BNT162b2 into human liver cell line Huh7, leading to changes in LINE-1 expression and distribution. We also show that BNT162b2 mRNA is reverse transcribed intracellularly into DNA in as fast as 6 h upon BNT162b2 exposure.", "doi": "10.3390/cimb44030073", "pmid": "35723296", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "cimb44030073"}, {"db": "pmc", "key": "PMC8946961"}], "notes": [], "created": "2022-06-20T18:01:55.926Z", "modified": "2022-08-17T12:44:56.372Z"}, {"entity": "publication", "iuid": "4df609687e91421ebc10c9fc487f13f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4df609687e91421ebc10c9fc487f13f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4df609687e91421ebc10c9fc487f13f9"}}, "title": "The impact of COVID-19 related regulations and restrictions on mobility and potential for sustained climate mitigation across the Netherlands, Sweden and the UK: a data-based commentary.", "authors": [{"family": "Corker", "given": "Elizabeth", "initials": "E", "orcid": "0000-0002-2055-7493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72e2b85d3fc048b782da99c5e92e2774.json"}}, {"family": "Mitev", "given": "Kaloyan", "initials": "K", "orcid": "0000-0001-6148-4852", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa5cfd4a1b0642948d3d3728807b025b.json"}}, {"family": "Nilsson Lewis", "given": "Astrid", "initials": "A", "orcid": "0000-0002-2090-4379", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94deaedf05ea44f695bde2bd28d091a9.json"}}, {"family": "Tamis", "given": "Milan", "initials": "M"}, {"family": "Bouman", "given": "Thijs", "initials": "T", "orcid": "0000-0001-7940-892X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98f3843dc2dd49df9b163eb18e96ba04.json"}}, {"family": "Holmlid", "given": "Stefan", "initials": "S", "orcid": "0000-0002-2529-4303", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3caccddc41004ca58051819bfcbe4c1c.json"}}, {"family": "Lambe", "given": "Fiona", "initials": "F", "orcid": "0000-0003-3664-9891", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b83be50ea2ce4109a7f62a21760c0e22.json"}}, {"family": "Michie", "given": "Susan", "initials": "S", "orcid": "0000-0003-0063-6378", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2da07e2d6bd54e6aa3d3496c8bdac4d8.json"}}, {"family": "Osborne", "given": "Matthew", "initials": "M", "orcid": "0000-0003-0272-1496", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e75a8ae678b48078261ace855732360.json"}}, {"family": "Jan Renes", "given": "Reint", "initials": "R", "orcid": "0000-0003-2448-9480", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4926b953047471e9cc46fa18e978dff.json"}}, {"family": "Steg", "given": "Linda", "initials": "L", "orcid": "0000-0002-8375-9607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87f6c790280e4a17836805c5cd9beb80.json"}}, {"family": "Whitmarsh", "given": "Lorraine", "initials": "L", "orcid": "0000-0002-9054-1040", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d350670e761467cbfe8a92f59075ab6.json"}}], "type": "journal article", "published": "2022-02-24", "journal": {"title": "UCL Open Environ", "issn": "2632-0886", "issn-l": null, "volume": "4", "issue": null, "pages": "e032"}, "abstract": "Human behaviour change is necessary to meet targets set by the Paris Agreement to mitigate climate change. Restrictions and regulations put in place globally to mitigate the spread of COVID-19 during 2020 have had a substantial impact on everyday life, including many carbon-intensive behaviours such as transportation. Changes to transportation behaviour may reduce carbon emissions. Behaviour change theory can offer perspective on the drivers and influences of behaviour and shape recommendations for how policy-makers can capitalise on any observed behaviour changes that may mitigate climate change. For this commentary, we aimed to describe changes in data relating to transportation behaviours concerning working from home during the COVID-19 pandemic across the Netherlands, Sweden and the UK. We display these identified changes in a concept map, suggesting links between the changes in behaviour and levels of carbon emissions. We consider these changes in relation to a comprehensive and easy to understand model of behaviour, the Opportunity, Motivation Behaviour (COM-B) model, to understand the capabilities, opportunities and behaviours related to the observed behaviour changes and potential policy to mitigate climate change. There is now an opportunity for policy-makers to increase the likelihood of maintaining pro-environmental behaviour changes by providing opportunities, improving capabilities and maintaining motivation for these behaviours.", "doi": "10.14324/111.444/ucloe.000032", "pmid": "37228472", "labels": {"Category: Social Science & Humanities": null, "Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10208342"}], "notes": [], "created": "2023-10-04T05:12:20.944Z", "modified": "2023-10-04T08:15:41.184Z"}, {"entity": "publication", "iuid": "4ab647b562b74e799cbad8075838427f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ab647b562b74e799cbad8075838427f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ab647b562b74e799cbad8075838427f"}}, "title": "Duration of SARS-CoV-2 Immune Responses Up to Six Months Following Homologous or Heterologous Primary Immunization with ChAdOx1 nCoV-19 and BNT162b2 mRNA Vaccines.", "authors": [{"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f28f2f6ac9648629c2d2de92fe7bb59.json"}}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/305bca9e5c6c423898c272bf06ce2f2a.json"}}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Nilsson", "given": "Charlotta", "initials": "C"}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2022-02-24", "journal": {"title": "Vaccines", "issn": "2076-393X", "issn-l": null, "volume": "10", "issue": "3", "pages": "359"}, "abstract": "Heterologous primary immunization against SARS-CoV-2 is part of applied recommendations. However, little is known about duration of immune responses after heterologous vaccine regimens. To evaluate duration of immune responses after primary vaccination with homologous adeno-vectored ChAdOx1 nCoV-19 vaccine (ChAd) or heterologous ChAd/BNT162b2 mRNA vaccine (BNT), anti-spike-IgG and SARS-CoV-2 VOC-neutralizing antibody responses were measured in 354 healthcare workers (HCW) at 2 weeks, 3 months, 5 months and 6 months after the second vaccine dose. T-cell responses were investigated using a whole blood interferon gamma (IFN-\u03b3) release assay 2 weeks and 3 months post second vaccine dose. Two hundred and ten HCW immunized with homologous BNT were enrolled for comparison of antibody responses. In study participants na\u00efve to SARS-CoV-2 prior to vaccination, heterologous ChAd/BNT resulted in 6-fold higher peak anti-spike IgG antibody titers compared to homologous ChAd vaccination. The half-life of antibody titers was 3.1 months (95% CI 2.8-3.6) following homologous ChAd vaccination and 1.9 months (95% CI 1.7-2.1) after heterologous vaccination, reducing the GMT difference between the groups to 3-fold 6 months post vaccination. Peak T-cell responses were stronger in ChAd/BNT vaccinees, but no significant difference was observed 3 months post vaccination. SARS-CoV-2 infection prior to vaccination resulted in substantially higher peak GMTs and IFN-\u03b3 levels and enhanced SARS-CoV-2 specific antibody and T cell responses over time. Heterologous primary SARS-CoV-2 immunization with ChAd and BNT elicits a stronger initial immune response compared to homologous vaccination with ChAd. However, although the differences in humoral responses remain over 6 months, the difference in SARS-CoV-2 specific T cell responses are no longer significant three months after vaccination.", "doi": "10.3390/vaccines10030359", "pmid": "35334989", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null, "Funder: VR": null, "Research Area: Drug discovery and repurposing of drugs": null, "Research Area: High-throughput and high-content serology": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC8953845"}, {"db": "pii", "key": "vaccines10030359"}], "notes": [], "created": "2022-03-28T16:45:51.963Z", "modified": "2023-06-19T14:27:58.481Z"}, {"entity": "publication", "iuid": "248d757ee8874cc4a15d38810b8a6e3e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/248d757ee8874cc4a15d38810b8a6e3e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/248d757ee8874cc4a15d38810b8a6e3e"}}, "title": "Influence of the COVID-19 pandemic on abortions and births in Sweden: a mixed-methods study.", "authors": [{"family": "Rydelius", "given": "Johanna", "initials": "J", "orcid": "0000-0003-3480-9177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93fdadd0e5504aa9bedb5f5f8071051b.json"}}, {"family": "Edalat", "given": "Mina", "initials": "M"}, {"family": "Nyman", "given": "Viola", "initials": "V"}, {"family": "Jar-Allah", "given": "Tagrid", "initials": "T", "orcid": "0000-0002-4394-6299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a4815ddb6224ebd8e14cbaa36b7166b.json"}}, {"family": "Milsom", "given": "Ian", "initials": "I"}, {"family": "Hognert", "given": "Helena", "initials": "H"}], "type": "journal article", "published": "2022-02-23", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "2", "pages": "e054076", "issn-l": "2044-6055"}, "abstract": "Although considered an essential service by the WHO, there are indications that access to induced abortion care has been restricted during the COVID-19 pandemic.\n\nTo investigate if the number of induced abortions and ongoing pregnancies changed during the first pandemic wave of COVID-19 in 2020 compared with recent years prior to the pandemic and explore possible reasons for the findings.\n\nConvergent parallel mixed-methods design. Collection of quantitative data from the Swedish National Board of Health and Welfare and the Swedish Pregnancy Register, and qualitative data from interviews.\n\nNational data on abortions (January 2018-June 2020) and births (January 2018-March 2021). Interviews performed at the main abortion clinic, Gothenburg, Sweden, in June 2020.\n\nAll women aged 15-44 years living in Sweden 2018-2020, approximately 1.9 million. 15 women who sought abortion were interviewed.\n\nNumber of abortions and births/1000 women aged 15-44 years. Themes and subthemes identified from interviews.\n\nThe number of abortions and ongoing pregnancies did not change significantly during the study period compared with before the pandemic started. Interview themes identified were the following: meeting with abortion care during the COVID-19 pandemic (availability, and fear of being infected and infecting others); and the impact of the COVID-19 pandemic on the abortion decision (to catch COVID-19 during pregnancy, feelings of loneliness and isolation, and social aspects).\n\nThis study shows that the number of abortions and ongoing pregnancies remained unchanged during the first wave of the COVID-19 pandemic in 2020 in Sweden compared with before the start of the pandemic. Abortion-seeking women did not hesitate to proceed with the abortion. The women expressed a number of fears concerning both availability of care and their health, which could have been properly addressed by the authorities.", "doi": "10.1136/bmjopen-2021-054076", "pmid": "35197343", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8882666"}, {"db": "pii", "key": "bmjopen-2021-054076"}], "notes": [], "created": "2023-01-13T13:33:02.465Z", "modified": "2023-01-13T13:33:02.532Z"}, {"entity": "publication", "iuid": "29818ab97c8a40bdaa3e46989a7512f3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/29818ab97c8a40bdaa3e46989a7512f3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/29818ab97c8a40bdaa3e46989a7512f3"}}, "title": "Evaluation of Simple Lateral Flow Immunoassays for Detection of SARS-CoV-2 Neutralizing Antibodies.", "authors": [{"family": "Nickel", "given": "Olaf", "initials": "O"}, {"family": "Rockstroh", "given": "Alexandra", "initials": "A", "orcid": "0000-0003-1317-5857", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0f920f4daa4468ca4826d82f45f647d.json"}}, {"family": "Borte", "given": "Stephan", "initials": "S"}, {"family": "Wolf", "given": "Johannes", "initials": "J"}], "type": "journal article", "published": "2022-02-23", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "3", "issn-l": null}, "abstract": "Immunization for the generation of protective antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged to be highly effective in preventing hospital admission, need for intensive care treatment and high mortality in the current SARS-CoV-2 pandemic. Lateral flow immune assays (LFIAs) offer a simple and competitive option to monitor antibody production after vaccination. Here, we compared the diagnostic performance of three different lateral flow assays in detecting nucleocapsid protein (NP), S1 subunit (S1) and receptor binding domain (pseudo)-neutralizing antibodies (nRBD) in sera of 107 health care workers prior (V1), two weeks (V2) after first vaccination with BNT162b2 as well as three weeks (V3) and eight months later (V4). In sera at V1, overall specificity was &gt;99%. At V3, LFIAs showed sensitivities between 98.1 and 100%. The comparison of S1 and nRBD LFIA with S1 ELISA and a focus reduction neutralization assay (FRNT) revealed high concordance at V3. Thus, the use of lateral flow immunoassays appears to have reasonable application in the short-term follow-up after vaccination for SARS-CoV-2.", "doi": "10.3390/vaccines10030347", "pmid": "35334979", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "vaccines10030347"}, {"db": "pmc", "key": "PMC8949379"}], "notes": [], "created": "2022-04-04T06:56:07.322Z", "modified": "2022-04-04T06:56:07.376Z"}, {"entity": "publication", "iuid": "2c7797a41e6e44f99348af9ff69c55fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c7797a41e6e44f99348af9ff69c55fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c7797a41e6e44f99348af9ff69c55fa"}}, "title": "Analysis of B Cell Receptor Repertoires Reveals Key Signatures of the Systemic B Cell Response after SARS-CoV-2 Infection.", "authors": [{"family": "Zhang", "given": "Yudi", "initials": "Y"}, {"family": "Yan", "given": "Qihong", "initials": "Q"}, {"family": "Luo", "given": "Kun", "initials": "K"}, {"family": "He", "given": "Ping", "initials": "P"}, {"family": "Hou", "given": "Ruitian", "initials": "R"}, {"family": "Zhao", "given": "Xinwei", "initials": "X"}, {"family": "Wang", "given": "Qian", "initials": "Q"}, {"family": "Yi", "given": "Haisu", "initials": "H"}, {"family": "Liang", "given": "Huan", "initials": "H"}, {"family": "Deng", "given": "Yijun", "initials": "Y"}, {"family": "Hu", "given": "Fengyu", "initials": "F"}, {"family": "Li", "given": "Feng", "initials": "F"}, {"family": "Liu", "given": "Xinglong", "initials": "X"}, {"family": "Feng", "given": "Ying", "initials": "Y"}, {"family": "Li", "given": "Pingchao", "initials": "P"}, {"family": "Qu", "given": "Linbing", "initials": "L"}, {"family": "Chen", "given": "Zhaoming", "initials": "Z"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}, {"family": "Feng", "given": "Liqiang", "initials": "L", "orcid": "0000-0001-6811-2074", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14d1a8f7ddbc4eeeb9f23a2efc12a2fd.json"}}, {"family": "Niu", "given": "Xuefeng", "initials": "X"}, {"family": "Chen", "given": "Ling", "initials": "L", "orcid": "0000-0003-1485-1626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b461d2c202447e6b4bc7ec60a46f51b.json"}}], "type": "journal article", "published": "2022-02-23", "journal": {"title": "J Virol", "issn": "1098-5514", "pages": "e0160021", "volume": "96", "issue": "4", "issn-l": "0022-538X"}, "abstract": "A comprehensive study of the B cell response against SARS-CoV-2 could be significant for understanding the immune response and developing therapeutical antibodies and vaccines. To define the dynamics and characteristics of the antibody repertoire following SARS-CoV-2 infection, we analyzed the mRNA transcripts of immunoglobulin heavy chain (IgH) repertoires of 24 peripheral blood samples collected between 3 and 111 days after symptom onset from 10 COVID-19 patients. Massive clonal expansion of naive B cells with limited somatic hypermutation (SHM) was observed in the second week after symptom onset. The proportion of low-SHM IgG clones strongly correlated with spike-specific IgG antibody titers, highlighting the significant activation of naive B cells in response to a novel virus infection. The antibody isotype switching landscape showed a transient IgA surge in the first week after symptom onset, followed by a sustained IgG elevation that lasted for at least 3 months. SARS-CoV-2 infection elicited poly-germ line reactive antibody responses. Interestingly, 17 different IGHV germ line genes recombined with IGHJ6 showed significant clonal expansion. By comparing the IgH repertoires that we sequenced with the 774 reported SARS-CoV-2-reactive monoclonal antibodies (MAbs), 13 shared spike-specific IgH clusters were found. These shared spike-specific IgH clusters are derived from the same lineage of several recently published neutralizing MAbs, including CC12.1, CC12.3, C102, REGN10977, and 4A8. Furthermore, identical spike-specific IgH sequences were found in different COVID-19 patients, suggesting a highly convergent antibody response to SARS-CoV-2. Our analysis based on sequencing antibody repertoires from different individuals revealed key signatures of the systemic B cell response induced by SARS-CoV-2 infection. IMPORTANCE Although the canonical delineation of serum antibody responses following SARS-CoV-2 infection has been well established, the dynamics of antibody repertoire at the mRNA transcriptional level has not been well understood, especially the correlation between serum antibody titers and the antibody mRNA transcripts. In this study, we analyzed the IgH transcripts and characterized the B cell clonal expansion and differentiation, isotype switching, and somatic hypermutation in COVID-19 patients. This study provided insights at the repertoire level for the B cell response after SARS-CoV-2 infection.", "doi": "10.1128/JVI.01600-21", "pmid": "34878902", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8865482"}], "notes": [], "created": "2021-12-12T07:15:16.732Z", "modified": "2023-06-19T15:34:31.225Z"}, {"entity": "publication", "iuid": "3a9d5263f1c44630b90a37fbb88a8ae0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a9d5263f1c44630b90a37fbb88a8ae0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a9d5263f1c44630b90a37fbb88a8ae0"}}, "title": "SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells.", "authors": [{"family": "Hammer", "given": "Quirin", "initials": "Q"}, {"family": "Dunst", "given": "Josefine", "initials": "J"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Picarazzi", "given": "Francesca", "initials": "F"}, {"family": "Wendorff", "given": "Mareike", "initials": "M"}, {"family": "Momayyezi", "given": "Pouria", "initials": "P"}, {"family": "Huhn", "given": "Ois\u00edn", "initials": "O"}, {"family": "Netskar", "given": "Herman K", "initials": "HK"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Garc\u00eda", "given": "Marina", "initials": "M"}, {"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "Sohlberg", "given": "Ebba", "initials": "E"}, {"family": "Azzimato", "given": "Valerio", "initials": "V"}, {"family": "Aouadi", "given": "Myriam", "initials": "M"}, {"family": "Karolinska COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Severe COVID-19 GWAS Group", "given": "", "initials": ""}, {"family": "Degenhardt", "given": "Frauke", "initials": "F"}, {"family": "Franke", "given": "Andre", "initials": "A"}, {"family": "Spallotta", "given": "Francesco", "initials": "F"}, {"family": "Mori", "given": "Mattia", "initials": "M"}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "R\u00fcckert", "given": "Timo", "initials": "T"}, {"family": "Romagnani", "given": "Chiara", "initials": "C"}, {"family": "Horowitz", "given": "Amir", "initials": "A"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Malmberg", "given": "Karl-Johan", "initials": "K"}], "type": "journal article", "published": "2022-02-21", "journal": {"title": "Cell Rep", "issn": "2211-1247", "issn-l": null, "volume": null, "issue": null, "pages": "110503"}, "abstract": "Natural killer (NK) cells are innate immune cells that contribute to host defense against virus infections. NK cells respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and are activated in patients with acute coronavirus disease 2019 (COVID-19). However, by which mechanisms NK cells detect SARS-CoV-2-infected cells remains largely unknown. Here, we show that the Non-structural protein 13 of SARS-CoV-2 encodes for a peptide that is presented by human leukocyte antigen E (HLA-E). In contrast with self-peptides, the viral peptide prevents binding of HLA-E to the inhibitory receptor NKG2A, thereby rendering target cells susceptible to NK cell attack. In line with these observations, NKG2A-expressing NK cells are particularly activated in patients with COVID-19 and proficiently limit SARS-CoV-2 replication in infected lung epithelial cells in vitro. Thus, these data suggest that a viral peptide presented by HLA-E abrogates inhibition of NKG2A+ NK cells, resulting in missing self-recognition.", "doi": "10.1016/j.celrep.2022.110503", "pmid": "35235832", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2211-1247(22)00239-X"}, {"db": "URL", "key": "https://covid19cellatlas.com/", "description": "https://covid19cellatlas.com/"}], "notes": [], "created": "2022-03-04T06:21:37.615Z", "modified": "2022-03-04T06:22:07.859Z"}, {"entity": "publication", "iuid": "e857ddb683104a0f8f752d24ed30fb87", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e857ddb683104a0f8f752d24ed30fb87.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e857ddb683104a0f8f752d24ed30fb87"}}, "title": "A cohort study of trauma patients in Sweden during the first months of the COVID-19 pandemic: a small reduction in trauma admissions.", "authors": [{"family": "B\u00e4ckstr\u00f6m", "given": "Denise", "initials": "D", "orcid": "0000-0003-4075-4600", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b67dde528cb4fa2b5df5ab9c15f9faa.json"}}, {"family": "Wladis", "given": "Andreas", "initials": "A", "orcid": "0000-0003-4377-0892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e5c5716282a4d63a4ade70eb160f432.json"}}], "type": "journal article", "published": "2022-02-19", "journal": {"title": "Scand J Trauma Resusc Emerg Med", "issn": "1757-7241", "volume": "30", "issue": "1", "pages": "12", "issn-l": "1757-7241"}, "abstract": "Given that Swedish authorities have been widely viewed as having practiced an unusual approach to the COVID-19 pandemic and given that Sweden is notable for a low incidence of trauma, we wanted to learn how the pandemic may have affected the number of trauma admissions in Sweden.\n\nWe conducted a retrospective cohort study based on the Swedish trauma registry (Svenska Traumaregistret). The study period was March 1, 2020 to June 30, 2020. As a basis for comparison, the record for the same time during the previous year, 2019 was used.\n\nDuring the four months of the first wave of COVID-19, 2020 there was a decline of 24.2% in the total number of trauma patients in Sweden. There was no significant change in 30-day mortality rates, 4.7% 2019 and 5.1% 2020, (p = 0.30). The number of injuries per patient was higher during the pandemic 3.8 injuries 2019 and 4.1 injuries 2020 (p = 0.02). The NISS 6, 2019 and 8, 2020 was higher during the pandemic.\n\nAs a consequence of what were seen by many as all too lenient actions taken to deal with COVID-19 in Sweden during spring 2020, there was still a reduction in trauma admissions most likely due to an adherence to the voluntary recommendations, the reduction was not as prominent as what was seen in many countries with harsher restrictions and lockdowns.", "doi": "10.1186/s13049-022-01001-9", "pmid": "35183237", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8857878"}, {"db": "pii", "key": "10.1186/s13049-022-01001-9"}], "notes": [], "created": "2023-01-13T13:43:40.759Z", "modified": "2023-01-13T13:43:40.841Z"}, {"entity": "publication", "iuid": "3f2c42bc11e742e0a6ecca5cad896f2b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f2c42bc11e742e0a6ecca5cad896f2b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f2c42bc11e742e0a6ecca5cad896f2b"}}, "title": "Prevalence and predictive factors of complementary medicine use during the first wave of the COVID-19 pandemic of 2020 in the Netherlands.", "authors": [{"family": "Mulder", "given": "Louise T C", "initials": "LTC"}, {"family": "Busch", "given": "Martine", "initials": "M"}, {"family": "Kristoffersen", "given": "Agnete E", "initials": "AE"}, {"family": "H\u00f6k Nordberg", "given": "Johanna", "initials": "J"}, {"family": "van der Werf", "given": "Esther T", "initials": "ET"}], "type": "journal article", "published": "2022-02-15", "journal": {"title": "BMC Complement Med Ther", "issn": "2662-7671", "volume": "22", "issue": "1", "pages": "43", "issn-l": null}, "abstract": "Major life changing events such as the COVID-19 pandemic may have major impact on one's health and general well-being. This study aimed to determine the prevalence and predictive factors, including gender specific differences, of Complementary Medicine (CM) use (including CM consultations, self-care management and self-help techniques) during the first wave of the COVID-19 pandemic in 2020 in the Netherlands.\n\nCM use was studied among a random representative sample (n = 1004) of the adult Dutch population using an online survey conducted from 22-27 May 2020. The survey included a modified version of I-CAM-Q and additional questions on demographic characteristics, reasons for CM use, perceived effectiveness and side effects.\n\n68.0% of the participants reported to have used CM (CM consultations (13.3%), self-management strategies (59.4%), self-help techniques (30.0%)). Most frequently reported reason of CM use was to improve general well-being (61.6%), prevention and/or treatment of COVID-19 was only reported by 10%. Perceived effectiveness of CM was high and number of experienced side effects low. Being a women, worried to get infected with COVID-19, higher education and living in northern/ middle region of the Netherlands were predictive factors to use CM.\n\nIn the Netherlands, specific groups (e.g. women/ highly educated) use CM, mainly to improve general wellbeing, and seem to benefit of it during the first months of the pandemic. The high perceived effectiveness and low reporting of side effects should encourage medical professionals and policy makers for more openness towards considering CM as being part of an integrative approach to public health in times life changing events occur.", "doi": "10.1186/s12906-022-03528-x", "pmid": "35168630", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12906-022-03528-x"}], "notes": [], "created": "2022-02-17T06:06:01.985Z", "modified": "2022-02-17T06:06:02.017Z"}, {"entity": "publication", "iuid": "1d0e188b725548c192dee5a9bea8fc74", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d0e188b725548c192dee5a9bea8fc74.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d0e188b725548c192dee5a9bea8fc74"}}, "title": "An extended version of Necessary Condition Analysis (NCA) allows more specific conclusions: an example involving well-being and resilience.", "authors": [{"family": "Sorjonen", "given": "Kimmo", "initials": "K"}, {"family": "Melin", "given": "Bo", "initials": "B"}], "type": "journal article", "published": "2022-02-15", "journal": {"title": "BMC Psychiatry", "issn": "1471-244X", "volume": "22", "issue": "1", "pages": "121", "issn-l": null}, "abstract": "After conducting necessary condition analysis (NCA), researchers have concluded that a certain, not too low, level of well-being is necessary but not sufficient for a high level of resilience. However, as acknowledged by the developers of the test, NCA only evaluates if the association between two variables is characterized by some unspecified type of non-randomness and not conditions of necessity.\n\nEarlier reported data on the association between well-being and resilience among Filipino adults (N = 533) in COVID-19 quarantine were re-analyzed with an extended version of NCA.\n\nAnalyses indicated a significant necessity effect of resilience on overall well-being, which is not logically compatible with well-being being necessary but not sufficient for resilience. Analyses with an extended version of NCA suggested that the association between overall well-being and resilience was characterized by equal degrees of necessity and sufficiency.\n\nThe original version of NCA is only capable of evaluating if the association between two variables is characterized by some unspecified type of non-randomness. The extended version of NCA allows researchers to draw more specific conclusions.", "doi": "10.1186/s12888-022-03774-w", "pmid": "35168598", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12888-022-03774-w"}], "notes": [], "created": "2022-02-17T06:06:20.614Z", "modified": "2022-02-17T06:06:20.629Z"}, {"entity": "publication", "iuid": "5f5fd2ae90834b769970e07dfc15b2ba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f5fd2ae90834b769970e07dfc15b2ba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f5fd2ae90834b769970e07dfc15b2ba"}}, "title": "Ventilator-Associated Lower Respiratory Tract Bacterial Infections in COVID-19 Compared With Non-COVID-19 Patients.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P"}, {"family": "Ternhag", "given": "Anders", "initials": "A"}, {"family": "Giske", "given": "Christian G", "initials": "CG"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "\u00d6zenci", "given": "Volkan", "initials": "V"}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Spindler", "given": "Carl", "initials": "C"}, {"family": "Hedlund", "given": "Jonas", "initials": "J"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2022-02-14", "journal": {"title": "Crit Care Med", "issn": "1530-0293", "issn-l": null}, "abstract": "Ventilator-associated lower respiratory tract infections (VA-LRTIs) are associated with prolonged length of stay and increased mortality. We aimed to investigate the occurrence of bacterial VA-LRTI among mechanically ventilated COVID-19 patients and compare these findings to non-COVID-19 cohorts throughout the first and second wave of the pandemic.\n\nRetrospective cohort study.\n\nKarolinska University Hospital, Stockholm, Sweden.\n\nAll patients greater than or equal to 18 years treated with mechanical ventilation between January 1, 2011, and December 31, 2020.\n\nNone.\n\nThe cohort consisted of 20,223 ICU episodes (479 COVID-19), with a VA-LRTI incidence proportion of 30% (129/426) in COVID-19 and 18% (1,081/5,907) in non-COVID-19 among patients ventilated greater than or equal to 48 hours. The median length of ventilator treatment for COVID-19 patients was 10 days (interquartile range, 5-18 d), which was significantly longer than for all other investigated specific diagnoses. The VA-LRTI incidence rate per 1,000 ventilator days at risk was 31 (95% CI, 26-37) for COVID-19 and 34 (95% CI, 32-36) for non-COVID-19. With COVID-19 as reference, adjusted subdistribution hazard ratios for VA-LRTI was 0.29-0.50 (95% CI, < 1) for influenza, bacterial pneumonia, acute respiratory distress syndrome, and severe sepsis, but 1.38 (95% CI, 1.15-1.65) for specific noninfectious diagnoses. Compared with COVID-19 in the first wave of the pandemic, COVID-19 in the second wave had adjusted subdistribution hazard ratio of 1.85 (95% CI, 1.14-2.99). In early VA-LRTI Staphylococcus aureus was more common and Streptococcus pneumoniae, Haemophilus influenzae, and Escherichia coli less common in COVID-19 patients, while Serratia species was more often identified in late VA-LRTI.\n\nCOVID-19 is associated with exceptionally long durations of mechanical ventilation treatment and high VA-LRTI occurrence proportions. The incidence rate of VA-LRTI was compared with the pooled non-COVID-19 cohort, however, not increased in COVID-19. Significant differences in the incidence of VA-LRTI occurred between the first and second wave of the COVID-19 pandemic.", "doi": "10.1097/CCM.0000000000005462", "pmid": "35148524", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "00003246-900000000-94988"}], "notes": [], "created": "2022-02-17T06:15:35.140Z", "modified": "2022-02-17T06:15:35.176Z"}, {"entity": "publication", "iuid": "7a8e4aefcd1740baa1e0c375af71e6fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a8e4aefcd1740baa1e0c375af71e6fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a8e4aefcd1740baa1e0c375af71e6fc"}}, "title": "COVID-19 related distress in the Swedish population: Validation of the Swedish version of the COVID Stress Scales (CSS).", "authors": [{"family": "Carlander", "given": "Anders", "initials": "A", "orcid": "0000-0002-4435-7648", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb81228e2951462ab407f261fa9e6d02.json"}}, {"family": "Lekander", "given": "Mats", "initials": "M"}, {"family": "Asmundson", "given": "Gordon J G", "initials": "GJG"}, {"family": "Taylor", "given": "Steven", "initials": "S"}, {"family": "Olofsson Bagge", "given": "Roger", "initials": "R"}, {"family": "Lindqvist Bagge", "given": "Ann-Sophie", "initials": "AS"}], "type": "journal article", "published": "2022-02-14", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "2", "pages": "e0263888", "issn-l": "1932-6203"}, "abstract": "The COVID Stress Scales (CSS) assess health- and contamination-related distress in the face of a medical outbreak like the ongoing COVID-19 pandemic. Though the CSS is translated into 21 languages, it has not been validated in a Swedish national sample.\n\nOur general objective is to provide a translation, replication, and validation of the CSS and test its convergent- and discriminant validity in relation to anxiety, health anxiety, depression, and stress in the general Swedish population. We also present latent psychometric properties by modelling based on item response theory.\n\nParticipants consisted of 3044 Swedish adults (> 18 years) from a pre-stratified (gender, age, and education) sample from The Swedish Citizen Panel. Mental health status was assessed by validated instruments, including the CSS, PHQ-4, SHAI-14, and PSS-10.\n\nResults indicate that our Swedish translation of CSS has good psychometric properties and consists of 5 correlated factors.\n\nThe CSS is useful either as a unidimensional or multidimensional construct using the CSS scales to measure key facets of pandemic-related stress.\n\nThe findings support the cross-cultural validity of the CSS and its potential utility in understanding many of the emotional challenges posed by the current and future pandemics.", "doi": "10.1371/journal.pone.0263888", "pmid": "35157739", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-37902"}], "notes": [], "created": "2022-02-17T06:11:53.292Z", "modified": "2022-02-17T06:11:53.339Z"}, {"entity": "publication", "iuid": "7fab07b5f64e4a5393a2b95e5f9286dc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7fab07b5f64e4a5393a2b95e5f9286dc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7fab07b5f64e4a5393a2b95e5f9286dc"}}, "title": "Association between pharmaceutical modulation of oestrogen in postmenopausal women in Sweden and death due to COVID-19: a cohort study.", "authors": [{"family": "Sund", "given": "Malin", "initials": "M"}, {"family": "Fonseca-Rodr\u00edguez", "given": "Osvaldo", "initials": "O"}, {"family": "Josefsson", "given": "Andreas", "initials": "A"}, {"family": "Welen", "given": "Karin", "initials": "K"}, {"family": "Fors Connolly", "given": "Anne-Marie", "initials": "AM", "orcid": "0000-0001-9215-4047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff46cc7d9e374929a14350748727ba60.json"}}], "type": "journal article", "published": "2022-02-14", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "2", "pages": "e053032", "issn-l": "2044-6055"}, "abstract": "Determine whether augmentation of oestrogen in postmenopausal women decreases the risk of death following COVID-19.\n\nNationwide registry-based study in Sweden based on registries from the Swedish Public Health Agency (all individuals who tested positive for SARS-CoV-2); Statistics Sweden (socioeconomical variables) and the National Board of Health and Welfare (causes of death).\n\nPostmenopausal women between 50 and 80 years of age with verified COVID-19.\n\nPharmaceutical modulation of oestrogen as defined by (1) women with previously diagnosed breast cancer and receiving endocrine therapy (decreased systemic oestrogen levels); (2) women receiving hormone replacement therapy (increased systemic oestrogen levels) and (3) a control group not fulfilling requirements for group 1 or 2 (postmenopausal oestrogen levels). Adjustments were made for potential confounders such as age, annual disposable income (richest group as the reference category), highest level of education (primary, secondary and tertiary (reference)) and the weighted Charlson Comorbidity Index (wCCI).\n\nDeath following COVID-19.\n\nFrom a nationwide cohort consisting of 49 853 women diagnosed with COVID-19 between 4 February and 14 September 2020 in Sweden, 16 693 were between 50 and 80 years of age. We included 14 685 women in the study with 11 923 (81%) in the control group, 227 (2%) women in group 1 and 2535 (17%) women in group 2. The unadjusted ORs for death following COVID-19 were 2.35 (95% CI 1.51 to 3.65) for group 1 and 0.45 (0.34 to 0.6) for group 2. Only the adjusted OR for death remained significant for group 2 with OR 0.47 (0.34 to 0.63). Absolute risk of death was 4.6% for the control group vs 10.1% and 2.1%, for the decreased and increased oestrogen groups, respectively. The risk of death due to COVID-19 was significantly associated with: age, OR 1.15 (1.14 to 1.17); annual income, poorest 2.79 (1.96 to 3.97), poor 2.43 (91.71 to 3.46) and middle 1.64 (1.11 to 2.41); and education (primary 1.4 (1.07 to 1.81)) and wCCI 1.13 (1.1 to 1.16).\n\nOestrogen supplementation in postmenopausal women is associated with a decreased risk of dying from COVID-19 in this nationwide cohort study. These findings are limited by the retrospective and non-randomised design. Further randomised intervention trials are warranted.", "doi": "10.1136/bmjopen-2021-053032", "pmid": "35165090", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-053032"}], "notes": [], "created": "2022-02-17T06:07:13.014Z", "modified": "2022-02-17T06:07:27.088Z"}, {"entity": "publication", "iuid": "23d4b34eef6e4dc8b4019dc8d6f32450", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23d4b34eef6e4dc8b4019dc8d6f32450.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23d4b34eef6e4dc8b4019dc8d6f32450"}}, "title": "Assessment of maternal and child health care services performance in the context of COVID-19 pandemic in Addis Ababa, Ethiopia: evidence from routine service data.", "authors": [{"family": "Gebreegziabher", "given": "Senedu Bekele", "initials": "SB"}, {"family": "Marrye", "given": "Solomon Sisay", "initials": "SS"}, {"family": "Kumssa", "given": "Tsegaye Hailu", "initials": "TH"}, {"family": "Merga", "given": "Kassa Haile", "initials": "KH"}, {"family": "Feleke", "given": "Alemu Kibret", "initials": "AK"}, {"family": "Dare", "given": "Degu Jerene", "initials": "DJ"}, {"family": "Hallstr\u00f6m", "given": "Inger Kristensson", "initials": "IK"}, {"family": "Yimer", "given": "Solomon Abebe", "initials": "SA"}, {"family": "Shargie", "given": "Mulatu Biru", "initials": "MB"}], "type": "journal article", "published": "2022-02-14", "journal": {"title": "Reprod Health", "issn": "1742-4755", "volume": "19", "issue": "1", "pages": "42", "issn-l": null}, "abstract": "In many settings, health care service provision has been modified to managing COVID-19 cases, and this has been affecting the provision of maternal and child health services. The aim of this study was to assess trends in selected maternal and child health services performance in the context of COVID-19 pandemic.\n\nA cross-sectional data review was conducted in Addis Ababa, Ethiopia from April to May 2021. Routine health management information system database was reviewed from Addis Ababa Health Bureau for the period from July 2019 to March 2021 across all quarters. Proportion and mean with standard deviation were computed. T-test was used to assess statistically significant differences in services mean performance.\n\nPostnatal care visit, new contraceptives accepters, safe abortion care and number of under-5 years old children treated for pneumonia significantly decreased by 9.3% (p-value 0.04), 20.3% (p-value 0.004), 23.7% (p-value 0.01) and 77.2% (p-value < 0.001), respectively during the first 8 months of the COVID-19 pandemic compared to the previous 8 months' average performance. The trends in Antenatal care first visit, new contraceptive accepters, pentavalent-3 vaccination and under-five children treated for pneumonia began to decline in January to March 2020, a quarter when the COVID-19 pandemic began; with accelerated declines in April to June 2020 following national lockdown. The trends for the stated services began to increase during July-September 2020, the last quarter of national lockdown. Contraceptive accepters and pentavalent-1 vaccination continued to decline and showed no recovery until January-March 2021 when this study was completed.\n\nMost of the maternal and child health services performance declined following the onset of COVID-19 pandemic and national lockdown, and most of the services began recovering during July-September 2020, the last quarter of national lockdown. However, new and repeat contraceptive accepters and pentavalent-1 recipients continue to decline and show no recovery during end of the study period. Implementing COVID-19 prevention measures and assuring the community about the safety of service delivery is imperative to ensure continuity of the maternal and child health services. Regular monitoring and evaluation of services performance is required to identify slowly recovering services and respond to potentially volatile changes during the COVID-19 pandemic.", "doi": "10.1186/s12978-022-01353-6", "pmid": "35164776", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12978-022-01353-6"}], "notes": [], "created": "2022-02-17T06:08:00.863Z", "modified": "2022-02-17T06:08:11.512Z"}, {"entity": "publication", "iuid": "dae53a9eb16449ce83d40a8d36a3eb42", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dae53a9eb16449ce83d40a8d36a3eb42.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dae53a9eb16449ce83d40a8d36a3eb42"}}, "title": "Conceptual unclarity about COVID-19 ethnic disparities in Sweden: Implications for public health policy.", "authors": [{"family": "Bredstr\u00f6m", "given": "Anna", "initials": "A", "orcid": "0000-0001-5451-8540", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f5a6ad989aa4b82a0ec03e6090c16e1.json"}}, {"family": "Mulinari", "given": "Shai", "initials": "S", "orcid": "0000-0001-8773-9796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/affaf495414d44bca4566f0a37fcaf14.json"}}], "type": "journal article", "published": "2022-02-13", "journal": {"title": "Health (London)", "issn": "1461-7196", "pages": "13634593221074866", "issn-l": null}, "abstract": "The COVID-19 pandemic has shed light on abundant racial and ethnic health disparities in many countries around the world. In Sweden, statistics on COVID-19 mortality and morbidity from both the first and the second wave of the pandemic show that foreign-born individuals have been disproportionately affected, compared to Swedish-born individuals. However, as demonstrated in this article, key stakeholders including politicians, public authorities, mainstream media, and medical researchers do not draw on the same explanatory framework when conceptualizing the health disparity. Probing the different discourses that were articulated through oral and written accounts during the first wave, the article identifies three different frameworks of how ethnic health disparities in relation to COVID-19 were understood in Sweden: the socioeconomic framework, the culturalist framework and the biological framework. We discuss the importance of our findings for health policy and argue for continued interrogation of epidemiological knowledge production from a critical vantage point in order to successfully combat health inequalities.", "doi": "10.1177/13634593221074866", "pmid": "35152788", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-17T06:12:38.880Z", "modified": "2022-02-17T06:12:53.371Z"}, {"entity": "publication", "iuid": "107ba0ee394b4b7bb09b8756dbe17412", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/107ba0ee394b4b7bb09b8756dbe17412.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/107ba0ee394b4b7bb09b8756dbe17412"}}, "title": "Seroprevalence and T-cell response in 32 children 10 months after COVID-19.", "authors": [{"family": "Moritz", "given": "David", "initials": "D"}, {"family": "Krifors", "given": "Anders", "initials": "A"}, {"family": "Freyhult", "given": "Elisabeth", "initials": "E"}, {"family": "M\u00e5nsson", "given": "Emeli", "initials": "E", "orcid": "0000-0003-2867-1044", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b7d5d97f6954001a6e13398e992a01f.json"}}], "type": "journal article", "published": "2022-02-12", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253"}, "abstract": null, "doi": "10.1111/apa.16287", "pmid": "35150457", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Proteins": null}, "xrefs": [], "notes": [], "created": "2022-02-17T06:13:41.574Z", "modified": "2022-02-17T06:13:57.004Z"}, {"entity": "publication", "iuid": "6416fe9ee2414a359e25352a7fd27f1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6416fe9ee2414a359e25352a7fd27f1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6416fe9ee2414a359e25352a7fd27f1d"}}, "title": "Sequential lateral positioning as a new lung recruitment maneuver: an exploratory study in early mechanically ventilated Covid-19 ARDS patients.", "authors": [{"family": "Rold\u00e1n", "given": "Rollin", "initials": "R"}, {"family": "Rodriguez", "given": "Shalim", "initials": "S"}, {"family": "Barriga", "given": "Fernando", "initials": "F"}, {"family": "Tucci", "given": "Mauro", "initials": "M"}, {"family": "Victor", "given": "Marcus", "initials": "M"}, {"family": "Alcala", "given": "Glasiele", "initials": "G"}, {"family": "Villamonte", "given": "Ren\u00e1n", "initials": "R"}, {"family": "Su\u00e1rez-Sipmann", "given": "Fernando", "initials": "F"}, {"family": "Amato", "given": "Marcelo", "initials": "M"}, {"family": "Brochard", "given": "Laurent", "initials": "L"}, {"family": "Tusman", "given": "Gerardo", "initials": "G"}], "type": "journal article", "published": "2022-02-12", "journal": {"title": "Ann Intensive Care", "issn": "2110-5820", "volume": "12", "issue": "1", "pages": "13", "issn-l": null}, "abstract": "A sequential change in body position from supine-to-both lateral positions under constant ventilatory settings could be used as a postural recruitment maneuver in case of acute respiratory distress syndrome (ARDS), provided that sufficient positive end-expiratory pressure (PEEP) prevents derecruitment. This study aims to evaluate the feasibility and physiological effects of a sequential postural recruitment maneuver in early mechanically ventilated COVID-19 ARDS patients.\n\nA cohort of 15 patients receiving lung-protective mechanical ventilation in volume-controlled with PEEP based on recruitability were prospectively enrolled and evaluated in five sequentially applied positions for 30 min each: Supine-baseline; Lateral-1st side; 2nd Supine; Lateral-2nd side; Supine-final. PEEP level was selected using the recruitment-to-inflation ratio (R/I ratio) based on which patients received PEEP 12 cmH2O for R/I ratio \u2264 0.5 or PEEP 15 cmH2O for R/I ratio > 0.5. At the end of each period, we measured respiratory mechanics, arterial blood gases, lung ultrasound aeration, end-expiratory lung impedance (EELI), and regional distribution of ventilation and perfusion using electric impedance tomography (EIT).\n\nComparing supine baseline and final, respiratory compliance (29 \u00b1 9 vs 32 \u00b1 8 mL/cmH2O; p < 0.01) and PaO2/FIO2 ratio (138 \u00b1 36 vs 164 \u00b1 46 mmHg; p < 0.01) increased, while driving pressure (13 \u00b1 2 vs 11 \u00b1 2 cmH2O; p < 0.01) and lung ultrasound consolidation score decreased [5 (4-5) vs 2 (1-4); p < 0.01]. EELI decreased ventrally (218 \u00b1 205 mL; p < 0.01) and increased dorsally (192 \u00b1 475 mL; p = 0.02), while regional compliance increased in both ventral (11.5 \u00b1 0.7 vs 12.9 \u00b1 0.8 mL/cmH2O; p < 0.01) and dorsal regions (17.1 \u00b1 1.8 vs 18.8 \u00b1 1.8 mL/cmH2O; p < 0.01). Dorsal distribution of perfusion increased (64.8 \u00b1 7.3% vs 66.3 \u00b1 7.2%; p = 0.01).\n\nWithout increasing airway pressure, a sequential postural recruitment maneuver improves global and regional respiratory mechanics and gas exchange along with a redistribution of EELI from ventral to dorsal lung areas and less consolidation. Trial registration ClinicalTrials.gov, NCT04475068. Registered 17 July 2020, https://clinicaltrials.gov/ct2/show/NCT04475068.", "doi": "10.1186/s13613-022-00988-9", "pmid": "35150355", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13613-022-00988-9"}, {"db": "ClinicalTrials.gov", "key": "NCT04475068"}], "notes": [], "created": "2022-02-17T06:14:39.349Z", "modified": "2022-02-17T06:14:51.608Z"}, {"entity": "publication", "iuid": "ac88a0f3969e4dfa9f4b2ad6a11fc37f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac88a0f3969e4dfa9f4b2ad6a11fc37f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac88a0f3969e4dfa9f4b2ad6a11fc37f"}}, "title": "Re: Chen Dong, Sung-Lang Chen, and Wen-Wei Sung's Letter to the Editor re: Karin Wel\u00e9n, Ebba Rosendal, Magnus Gissl\u00e9n, et al. A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome: No Evidence of Benefit, Supported by Epidemiology and In Vitro Data. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2021.12.013.", "authors": [{"family": "Welen", "given": "Karin", "initials": "K"}, {"family": "Rosendal", "given": "Ebba", "initials": "E"}, {"family": "Freyhult", "given": "Eva", "initials": "E"}, {"family": "Fors Connolly", "given": "Anne-Marie", "initials": "AM"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "Josefsson", "given": "Andreas", "initials": "A"}], "type": "letter", "published": "2022-02-12", "journal": {"title": "Eur Urol", "issn": "1873-7560", "issn-l": null}, "abstract": null, "doi": "10.1016/j.eururo.2022.02.001", "pmid": "35168845", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0302-2838(22)01605-0"}], "notes": [], "created": "2022-02-17T06:05:27.796Z", "modified": "2022-02-17T06:05:27.801Z"}, {"entity": "publication", "iuid": "572357eb34bb4861a68ac67d1de20fd4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/572357eb34bb4861a68ac67d1de20fd4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/572357eb34bb4861a68ac67d1de20fd4"}}, "title": "Metabolic Rewiring and Serotonin Depletion in Patients with Post-Acute Sequelae of COVID-19.", "authors": [{"family": "Sadlier", "given": "Corinna", "initials": "C"}, {"family": "Albrich", "given": "Werner C", "initials": "WC"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}, {"family": "Lunjani", "given": "Nonhlanhla", "initials": "N"}, {"family": "Horgan", "given": "Mary", "initials": "M"}, {"family": "O'Toole", "given": "Paul W", "initials": "PW"}, {"family": "O'Mahony", "given": "Liam", "initials": "L"}], "type": "letter", "published": "2022-02-12", "journal": {"title": "Allergy", "issn": "1398-9995", "issn-l": "0105-4538"}, "abstract": null, "doi": "10.1111/all.15253", "pmid": "35150456", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-16T12:05:24.492Z", "modified": "2022-02-17T06:14:20.422Z"}, {"entity": "publication", "iuid": "ff5f3b87ac5f4a3c829af53686ae9225", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff5f3b87ac5f4a3c829af53686ae9225.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff5f3b87ac5f4a3c829af53686ae9225"}}, "title": "Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses.", "authors": [{"family": "Luttens", "given": "Andreas", "initials": "A", "orcid": "0000-0003-2915-7901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39b4f3a4039c4b6aa7e34b57cc923b47.json"}}, {"family": "Gullberg", "given": "Hjalmar", "initials": "H"}, {"family": "Abdurakhmanov", "given": "Eldar", "initials": "E"}, {"family": "Vo", "given": "Duy Duc", "initials": "DD"}, {"family": "Akaberi", "given": "Dario", "initials": "D", "orcid": "0000-0002-9595-9796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e5dfb70a38c41eea193ed13916cdf04.json"}}, {"family": "Talibov", "given": "Vladimir O", "initials": "VO"}, {"family": "Nekhotiaeva", "given": "Natalia", "initials": "N"}, {"family": "Vangeel", "given": "Laura", "initials": "L"}, {"family": "De Jonghe", "given": "Steven", "initials": "S", "orcid": "0000-0002-3872-6558", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b101386f055c47448a6c2c0ea91dfdb7.json"}}, {"family": "Jochmans", "given": "Dirk", "initials": "D"}, {"family": "Krambrich", "given": "Janina", "initials": "J"}, {"family": "Tas", "given": "Ali", "initials": "A"}, {"family": "Lundgren", "given": "Bo", "initials": "B"}, {"family": "Gravenfors", "given": "Ylva", "initials": "Y", "orcid": "0000-0001-6025-4908", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d3fad6d5ee52432db8f07099730198fe.json"}}, {"family": "Craig", "given": "Alexander J", "initials": "AJ"}, {"family": "Atilaw", "given": "Yoseph", "initials": "Y"}, {"family": "Sandstr\u00f6m", "given": "Anja", "initials": "A"}, {"family": "Moodie", "given": "Lindon W K", "initials": "LWK", "orcid": "0000-0002-9500-4535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee771ccfee70464cae2a25da0125ae82.json"}}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "van Hemert", "given": "Martijn J", "initials": "MJ"}, {"family": "Neyts", "given": "Johan", "initials": "J"}, {"family": "Lennerstrand", "given": "Johan", "initials": "J"}, {"family": "Kihlberg", "given": "Jan", "initials": "J", "orcid": "0000-0002-4205-6040", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e47b47a621b6402b935364d11e1a640a.json"}}, {"family": "Sandberg", "given": "Kristian", "initials": "K"}, {"family": "Danielson", "given": "U Helena", "initials": "UH", "orcid": "0000-0003-2728-0340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e14a218e8a44c75816b9843d0df3d0e.json"}}, {"family": "Carlsson", "given": "Jens", "initials": "J", "orcid": "0000-0003-4623-2977", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce715411f7d245f0973ab60fe2cd88c8.json"}}], "type": "journal article", "published": "2022-02-10", "journal": {"title": "J Am Chem Soc", "issn": "1520-5126", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Drugs targeting SARS-CoV-2 could have saved millions of lives during the COVID-19 pandemic, and it is now crucial to develop inhibitors of coronavirus replication in preparation for future outbreaks. We explored two virtual screening strategies to find inhibitors of the SARS-CoV-2 main protease in ultralarge chemical libraries. First, structure-based docking was used to screen a diverse library of 235 million virtual compounds against the active site. One hundred top-ranked compounds were tested in binding and enzymatic assays. Second, a fragment discovered by crystallographic screening was optimized guided by docking of millions of elaborated molecules and experimental testing of 93 compounds. Three inhibitors were identified in the first library screen, and five of the selected fragment elaborations showed inhibitory effects. Crystal structures of target-inhibitor complexes confirmed docking predictions and guided hit-to-lead optimization, resulting in a noncovalent main protease inhibitor with nanomolar affinity, a promising in vitro pharmacokinetic profile, and broad-spectrum antiviral effect in infected cells.", "doi": "10.1021/jacs.1c08402", "pmid": "35142215", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Category: Biochemistry": null, "Type: Journal article": null, "Research Area: Pandemic preparedness": null, "Funder: KAW/SciLifeLab": null, "Research Area: Drug discovery and repurposing of drugs": null}, "xrefs": [{"db": "URL", "key": "https://pubs.acs.org/doi/10.1021/jacs.1c08402.", "description": "https://pubs.acs.org/doi/10.1021/jacs.1c08402."}], "notes": [], "created": "2022-02-11T10:20:00.486Z", "modified": "2022-02-11T10:22:04.258Z"}, {"entity": "publication", "iuid": "e6dcf29c4d9547488fef7e7141f960e0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6dcf29c4d9547488fef7e7141f960e0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6dcf29c4d9547488fef7e7141f960e0"}}, "title": "Placental Tissue Destruction and Insufficiency from COVID-19 Causes Stillbirth and Neonatal Death from Hypoxic-Ischemic Injury: A Study of 68 Cases with SARS-CoV-2 Placentitis from 12 Countries.", "authors": [{"family": "Schwartz", "given": "David A", "initials": "DA"}, {"family": "Avvad-Portari", "given": "Elyzabeth", "initials": "E"}, {"family": "Bab\u00e1l", "given": "Pavel", "initials": "P"}, {"family": "Baldewijns", "given": "Marcella", "initials": "M"}, {"family": "Blomberg", "given": "Marie", "initials": "M"}, {"family": "Bouachba", "given": "Amine", "initials": "A"}, {"family": "Camacho", "given": "Jessica", "initials": "J"}, {"family": "Collardeau-Frachon", "given": "Sophie", "initials": "S"}, {"family": "Colson", "given": "Arthur", "initials": "A"}, {"family": "Dehaene", "given": "Isabelle", "initials": "I"}, {"family": "Ferreres", "given": "Joan Carles", "initials": "JC"}, {"family": "Fitzgerald", "given": "Brendan", "initials": "B"}, {"family": "Garrido-Pontnou", "given": "Marta", "initials": "M"}, {"family": "Gerges", "given": "Hazem", "initials": "H"}, {"family": "Hargitai", "given": "Beata", "initials": "B"}, {"family": "Helguera-Repetto", "given": "A Cecilia", "initials": "AC"}, {"family": "Holmstr\u00f6m", "given": "Sandra", "initials": "S"}, {"family": "Irles", "given": "Claudine Liliane", "initials": "CL"}, {"family": "Leijonhfvud", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Libbrecht", "given": "Sasha", "initials": "S"}, {"family": "Marton", "given": "Tam\u00e1s", "initials": "T"}, {"family": "McEntagart", "given": "Noel", "initials": "N"}, {"family": "Molina", "given": "James T", "initials": "JT"}, {"family": "Morotti", "given": "Raffaella", "initials": "R"}, {"family": "Nadal", "given": "Alfons", "initials": "A"}, {"family": "Navarro", "given": "Alexandra", "initials": "A"}, {"family": "Nelander", "given": "Maria", "initials": "M"}, {"family": "Oviedo", "given": "Angelica", "initials": "A"}, {"family": "Oyamada Otani", "given": "Andre Ricardo", "initials": "AR"}, {"family": "Papadogiannakis", "given": "Nikos", "initials": "N"}, {"family": "Petersen", "given": "Astrid C", "initials": "AC"}, {"family": "Roberts", "given": "Drucilla J", "initials": "DJ"}, {"family": "Saad", "given": "Ali G", "initials": "AG"}, {"family": "Sand", "given": "Anna", "initials": "A"}, {"family": "Schoenmakers", "given": "Sam", "initials": "S"}, {"family": "Sehn", "given": "Jennifer K", "initials": "JK"}, {"family": "Simpson", "given": "Preston R", "initials": "PR"}, {"family": "Thomas", "given": "Kristen", "initials": "K"}, {"family": "Valdespino-V\u00e1zquez", "given": "M Yolotzin", "initials": "MY"}, {"family": "van der Meeren", "given": "Lotte E", "initials": "LE"}, {"family": "Van Dorpe", "given": "Jo", "initials": "J"}, {"family": "Verdijk", "given": "Robert M", "initials": "RM"}, {"family": "Watkins", "given": "Jaclyn C", "initials": "JC"}, {"family": "Zaigham", "given": "Mehreen", "initials": "M"}], "type": "journal article", "published": "2022-02-10", "journal": {"title": "Arch Pathol Lab Med", "issn": "1543-2165", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Perinatal death is an increasingly important problem as the COVID-19 pandemic continues, but the mechanism of death has been unclear.\n\nTo evaluate the role of the placenta in causing stillbirth and neonatal death following maternal infection with COVID-19 and confirmed placental positivity for SARS-CoV-2.\n\nCase-based retrospective clinico-pathological analysis by a multinational group of 44 perinatal specialists from 12 countries of placental and autopsy pathology findings from 64 stillborns and 4 neonatal deaths having placentas testing positive for SARS-CoV-2 following delivery to mothers with COVID-19.\n\nAll 68 placentas had increased fibrin deposition and villous trophoblast necrosis and 66 had chronic histiocytic intervillositis, the three findings constituting SARS-CoV-2 placentitis. Sixty-three placentas had massive perivillous fibrin deposition. Severe destructive placental disease from SARS-CoV-2 placentitis averaged 77.7% tissue involvement. Other findings included multiple intervillous thrombi (37%; 25/68) and chronic villitis (32%; 22/68). The majority (19, 63%) of the 30 autopsies revealed no significant fetal abnormalities except for intrauterine hypoxia and asphyxia. Among all 68 cases, SARS-CoV-2 was detected from a body specimen in 16 of 28 cases tested, most frequently from nasopharyngeal swabs. Four autopsied stillborns had SARS-CoV-2 identified in internal organs.\n\nThe pathology abnormalities composing SARS-CoV-2 placentitis cause widespread and severe placental destruction resulting in placental malperfusion and insufficiency. In these cases, intrauterine and perinatal death likely results directly from placental insufficiency and fetal hypoxic-ischemic injury. There was no evidence that SARS-CoV-2 involvement of the fetus had a role in causing these deaths.", "doi": "10.5858/arpa.2022-0029-SA", "pmid": "35142798", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "477699"}], "notes": [], "created": "2022-02-11T10:15:45.874Z", "modified": "2022-02-17T06:16:40.734Z"}, {"entity": "publication", "iuid": "09663934bf94465288397f7dc679f5d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/09663934bf94465288397f7dc679f5d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/09663934bf94465288397f7dc679f5d0"}}, "title": "Broad anti-SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1/mRNA-1273 vaccination.", "authors": [{"family": "Kaku", "given": "Chengzi I", "initials": "CI", "orcid": "0000-0002-9854-8351", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be56dead52324203a9b37fc32f23626f.json"}}, {"family": "Champney", "given": "Elizabeth R", "initials": "ER"}, {"family": "Normark", "given": "Johan", "initials": "J", "orcid": "0000-0001-5831-4369", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cab4f084027e4e4b8f0e5113a499e5c6.json"}}, {"family": "Garcia", "given": "Marina", "initials": "M", "orcid": "0000-0002-9130-3933", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5b109d7a54e4c05a48e0f21c4432be6.json"}}, {"family": "Johnson", "given": "Carl E", "initials": "CE"}, {"family": "Ahlm", "given": "Clas", "initials": "C", "orcid": "0000-0003-2018-8592", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/833d0293b5d74bbabec63e922cd19d54.json"}}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f2dc27d02294a15a6f691be6aab641f.json"}}, {"family": "Sakharkar", "given": "Mrunal", "initials": "M", "orcid": "0000-0002-2717-5201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2694a69ce874c3f93cf4f9ed8d736dd.json"}}, {"family": "Ackerman", "given": "Margaret E", "initials": "ME", "orcid": "0000-0002-4253-3476", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10fea712c93441dd922bbcb531b46148.json"}}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE", "orcid": "0000-0001-6904-742X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e41c0e1c9c7b499fb3d844d4c572e7bb.json"}}, {"family": "Walker", "given": "Laura M", "initials": "LM", "orcid": "0000-0001-7704-3197", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a40fc6cfefc14436a12cc467c3cacd54.json"}}], "type": "journal article", "published": "2022-02-10", "journal": {"title": "Science", "issn": "1095-9203", "pages": "eabn2688", "issn-l": "0036-8075"}, "abstract": "Heterologous prime-boost immunization strategies have the potential to augment COVID-19 vaccine efficacy. We longitudinally profiled SARS-CoV-2 spike (S)-specific serological and memory B cell (MBC) responses in individuals receiving either homologous (ChAdOx1:ChAdOx1) or heterologous (ChAdOx1:mRNA-1273) prime-boost vaccination. Heterologous mRNA booster immunization induced higher serum neutralizing antibody and MBC responses against SARS-CoV-2 variants of concern (VOCs) compared to homologous ChAdOx1 boosting. Specificity mapping of circulating B cells revealed that mRNA-1273 boost immunofocused ChAdOx1-primed responses onto epitopes expressed on prefusion-stabilized S. Monoclonal antibodies isolated from mRNA-1273 boosted participants displayed overall higher binding affinities and increased breadth of reactivity against VOCs relative to those isolated from ChAdOx1-boosted individuals. Overall, the results provide molecular insight into the enhanced quality of the B cell response induced following heterologous mRNA booster vaccination.", "doi": "10.1126/science.abn2688", "pmid": "35143256", "labels": {"Category: Health": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-11T10:17:32.493Z", "modified": "2022-02-17T06:16:08.848Z"}, {"entity": "publication", "iuid": "bcdfcb32836f42e8b943b15ad2dd61a5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bcdfcb32836f42e8b943b15ad2dd61a5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bcdfcb32836f42e8b943b15ad2dd61a5"}}, "title": "Whole genome analysis and homology modeling of SARS-CoV-2 Indian isolate reveals potent FDA approved drug choice for treating COVID-19.", "authors": [{"family": "Velu", "given": "Periyannan", "initials": "P"}, {"family": "Rathinavel", "given": "Thirumalaisamy", "initials": "T", "orcid": "0000-0003-3137-5895", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25f33e7fd0634e568735a3641d573ef8.json"}}, {"family": "Kumarasamy", "given": "Suresh", "initials": "S", "orcid": "0000-0002-4931-7274", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c46cd8b2ab848aca02e70a5e1f12cd8.json"}}, {"family": "Iqbal", "given": "Muhammad Nasir", "initials": "MN", "orcid": "0000-0002-8875-8400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e141277ae6474ac2a3e1f17d1617834d.json"}}, {"family": "Noor", "given": "Hasnat", "initials": "H"}, {"family": "Ikram", "given": "Ayesha", "initials": "A"}, {"family": "Rajamanickam", "given": "Karthika", "initials": "K"}, {"family": "Shanmugam", "given": "Gnanendra", "initials": "G"}], "type": "journal article", "published": "2022-02-09", "journal": {"title": "J Biomol Struct Dyn", "issn": "1538-0254", "pages": "1-17", "issn-l": null}, "abstract": "Coronaviruses have caused enough devastation in the last two decades. These viruses have some rare features while sharing some common features. Novel coronavirus disease (nCoV-19) caused an outbreak with a fatality rate of 5%. It emerged from China and spread into many countries. The present research focused on genome analysis of Indian nCoV-19 Isolate and its translational product subjected to homology modeling and its subsequent molecular simulations to find out potent FDA approved drug for treating COVID-19. Phylogenetic analysis of SARS-CoV-2 Indian isolate shows close resemblance with 17 countries SARS-CoV-2 isolates. Homology modeling of four non-structural proteins translational product of Indian SARS-CoV-2 genome shows high similarity and allowed regions with the existing PDB deposited SARS-CoV-2 target proteins. Finally, these four generated proteins show more affinity with cobicistat, remdesivir and indinavir out of 14 screened FDA approved drugs in molecular docking which is further proven by molecular dynamics simulation and MMGBSA analysis of target ligand complex with best simulation trajectories. Overall our present research findings is that three proposed drugs namely cobicistat, remdesivir and indinavir showed higher interaction with the model SARS-CoV-2 viral target proteins from the Indian nCoV-19 isolate. These compounds could be used as a starting point for the creation of active antiviral drugs to combat the deadly COVID-19 virus during global pandemic and its subsequent viral infection waves across the globe.Communicated by Ramaswamy H. Sarma.", "doi": "10.1080/07391102.2022.2038272", "pmid": "35139758", "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-11T10:24:41.199Z", "modified": "2022-02-11T10:24:41.351Z"}, {"entity": "publication", "iuid": "d7a6ecface78453e933adb93c529d4ea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d7a6ecface78453e933adb93c529d4ea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d7a6ecface78453e933adb93c529d4ea"}}, "title": "The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury: State-of-the-Art Review.", "authors": [{"family": "Siripanthong", "given": "Bhurint", "initials": "B"}, {"family": "Asatryan", "given": "Babken", "initials": "B"}, {"family": "Hanff", "given": "Thomas C", "initials": "TC"}, {"family": "Chatha", "given": "Salman R", "initials": "SR"}, {"family": "Khanji", "given": "Mohammed Y", "initials": "MY"}, {"family": "Ricci", "given": "Fabrizio", "initials": "F"}, {"family": "Muser", "given": "Daniele", "initials": "D"}, {"family": "Ferrari", "given": "Victor A", "initials": "VA"}, {"family": "Nazarian", "given": "Saman", "initials": "S"}, {"family": "Santangeli", "given": "Pasquale", "initials": "P"}, {"family": "Deo", "given": "Rajat", "initials": "R"}, {"family": "Cooper", "given": "Leslie T", "initials": "LT"}, {"family": "Mohiddin", "given": "Saidi A", "initials": "SA"}, {"family": "Chahal", "given": "C Anwar A", "initials": "CAA"}], "type": "journal article", "published": "2022-02-09", "journal": {"title": "JACC Basic Transl Sci", "issn": "2452-302X", "issn-l": null}, "abstract": "The mechanisms of coronavirus disease 2019 (COVID-19)-related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity.", "doi": "10.1016/j.jacbts.2021.10.011", "pmid": "35165665", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2452-302X(21)00318-1"}, {"db": "pmc", "key": "PMC8828362"}], "notes": [], "created": "2022-02-17T06:06:45.486Z", "modified": "2022-02-17T06:06:45.521Z"}, {"entity": "publication", "iuid": "7616f43c137c4aa59370f1f07a770009", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7616f43c137c4aa59370f1f07a770009.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7616f43c137c4aa59370f1f07a770009"}}, "title": "Little support for a protective effect of ADT against COVID-19.", "authors": [{"family": "Josefsson", "given": "Andreas", "initials": "A", "orcid": "0000-0002-2013-0887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1ba4bf5497b4c6e9334948925e3be76.json"}}], "type": "editorial", "published": "2022-02-09", "journal": {"title": "Scand J Urol", "issn": "2168-1813", "issn-l": null, "volume": null, "issue": null, "pages": "1-2"}, "abstract": null, "doi": "10.1080/21681805.2022.2033313", "pmid": "35137649", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-11T10:24:56.477Z", "modified": "2022-02-11T10:25:30.715Z"}, {"entity": "publication", "iuid": "7673dbe3bac44bc5a6299833d4d3d98d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7673dbe3bac44bc5a6299833d4d3d98d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7673dbe3bac44bc5a6299833d4d3d98d"}}, "title": "Intimate physical contact between people from different households during the COVID-19 pandemic: a mixed-methods study from a large, quasi-representative survey (Natsal-COVID).", "authors": [{"family": "Sonnenberg", "given": "Pam", "initials": "P", "orcid": "0000-0002-1067-1583", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/703eb395b191407eb977ed908453cb30.json"}}, {"family": "Menezes", "given": "Dee", "initials": "D", "orcid": "0000-0002-1628-1228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7babe7d1c2694f6aadde9c1de8ed74be.json"}}, {"family": "Freeman", "given": "Lily", "initials": "L"}, {"family": "Maxwell", "given": "Karen J", "initials": "KJ", "orcid": "0000-0002-2264-6510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43d1a00df778443d880fac4894e93630.json"}}, {"family": "Reid", "given": "David", "initials": "D", "orcid": "0000-0001-6832-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9650baded4724b0fb749dbfea43e1632.json"}}, {"family": "Clifton", "given": "Soazig", "initials": "S", "orcid": "0000-0002-4171-0805", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7cea96a2c56409dab9f474144303c30.json"}}, {"family": "Tanton", "given": "Clare", "initials": "C", "orcid": "0000-0002-4612-1858", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adf2ed41e93f422aa32a1afe93895bed.json"}}, {"family": "Copas", "given": "Andrew", "initials": "A", "orcid": "0000-0001-8968-5963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0aee9dde1bb2497398a63252a713c88a.json"}}, {"family": "Riddell", "given": "Julie", "initials": "J", "orcid": "0000-0002-8084-4566", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9660f5597db42d19462b83c9f8a1be4.json"}}, {"family": "Dema", "given": "Emily", "initials": "E", "orcid": "0000-0002-7254-2023", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3843a1be6fc4e37ac3f8eeff9a2bbb2.json"}}, {"family": "Bos\u00f3 P\u00e9rez", "given": "Raquel", "initials": "R", "orcid": "0000-0001-7342-4566", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3d61e70a5874b4ea43a1d9d73333605.json"}}, {"family": "Gibbs", "given": "Jo", "initials": "J", "orcid": "0000-0001-5696-0260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8e88ce8b71e4ae3b03749616b5a9eab.json"}}, {"family": "Ridge", "given": "Mary-Clare", "initials": "MC", "orcid": "0000-0001-9621-4529", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fda16e5b838e4da895af4b74f233e246.json"}}, {"family": "Macdowall", "given": "Wendy", "initials": "W", "orcid": "0000-0001-5868-8336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3cfc1c64d9b84957a244f64c09b483bf.json"}}, {"family": "Unemo", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1710-2081", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed8c616c8c16456590342443393553cb.json"}}, {"family": "Bonell", "given": "Chris", "initials": "C", "orcid": "0000-0002-6253-6498", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eeec7c46459414a974c9f42cc3b2baa.json"}}, {"family": "Johnson", "given": "Anne M", "initials": "AM", "orcid": "0000-0003-1330-7100", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f878d2115174a69a8de743cc40b6a15.json"}}, {"family": "Mercer", "given": "Catherine H", "initials": "CH", "orcid": "0000-0002-4220-5034", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6332e0448a8b49c7ab019b7c75768df1.json"}}, {"family": "Mitchell", "given": "Kirstin", "initials": "K", "orcid": "0000-0002-4409-6601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2af6a4b606314786806e669e86b92ee0.json"}}, {"family": "Field", "given": "Nigel", "initials": "N", "orcid": "0000-0002-2825-6652", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a84330facf864cfe9a4a51550cea9543.json"}}], "type": "journal article", "published": "2022-02-09", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "2", "pages": "e055284", "issn-l": "2044-6055"}, "abstract": "Physical distancing as a non-pharmaceutical intervention aims to reduce interactions between people to prevent SARS-CoV-2 transmission. Intimate physical contact outside the household (IPCOH) may expand transmission networks by connecting households. We aimed to explore whether intimacy needs impacted adherence to physical distancing following lockdown in Britain in March 2020.\n\nThe Natsal-COVID web-panel survey (July-August 2020) used quota-sampling and weighting to achieve a quasi-representative population sample. We estimate reporting of IPCOH with a romantic/sexual partner in the 4 weeks prior to interview, describe the type of contact, identify demographic and behavioural factors associated with IPCOH and present age-adjusted ORs (aORs). Qualitative interviews (n=18) were conducted to understand the context, reasons and decision making around IPCOH.\n\nOf 6654 participants aged 18-59 years, 9.9% (95% CI 9.1% to 10.6%) reported IPCOH. IPCOH was highest in those aged 18-24 (17.7%), identifying as gay or lesbian (19.5%), and in steady non-cohabiting relationships (56.3%). IPCOH was associated with reporting risk behaviours (eg, condomless sex, higher alcohol consumption). IPCOH was less likely among those reporting bad/very bad health (aOR 0.54; 95% CI 0.32 to 0.93) but more likely among those with COVID-19 symptoms and/or diagnosis (aOR 1.34; 95% CI 1.10 to 1.65). Two-thirds (64.4%) of IPCOH was reported as being within a support bubble. Qualitative interviews found that people reporting IPCOH deliberated over, and made efforts to mitigate, the risks.\n\nGiven 90% of people did not report IPCOH, this contact may not be a large additional contributor to SARS-CoV-2 transmission, although heterogeneity exists within the population. Public health messages need to recognise how single people and partners living apart balance sexual intimacy and relationship needs with adherence to control measures.", "doi": "10.1136/bmjopen-2021-055284", "pmid": "35140158", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-055284"}], "notes": [], "created": "2022-02-11T10:24:02.508Z", "modified": "2022-02-11T10:24:19.538Z"}, {"entity": "publication", "iuid": "6b2601546e12410eb50fc403016bf292", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b2601546e12410eb50fc403016bf292.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b2601546e12410eb50fc403016bf292"}}, "title": "Working conditions in primary healthcare during the COVID-19 pandemic: an interview study with physicians in Sweden.", "authors": [{"family": "Fernemark", "given": "Hanna", "initials": "H", "orcid": "0000-0002-9029-4406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0cd7e6f1012a4ff08bf13b0a17385bfd.json"}}, {"family": "Skagerstr\u00f6m", "given": "Janna", "initials": "J"}, {"family": "Seing", "given": "Ida", "initials": "I"}, {"family": "H\u00e5rdstedt", "given": "Maria", "initials": "M"}, {"family": "Schildmeijer", "given": "Kristina", "initials": "K", "orcid": "0000-0002-0895-674X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05115c15c6834224851474c2635ded5d.json"}}, {"family": "Nilsen", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2022-02-08", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "2", "pages": "e055035", "issn-l": "2044-6055"}, "abstract": "The aim of this study was to explore how the COVID-19 pandemic changed the working conditions of physicians in Swedish primary healthcare.\n\nThis is a descriptive, qualitative study with individual semistructured interviews. Data were analysed using inductive content analysis.\n\nSwedish primary healthcare units in both rural and urban areas.\n\nA total of 11 primary care physicians fulfilled participation.\n\nTwo main categories emerged: 'work organisation and routines' and 'psychosocial work environment', containing three and five subcategories, respectively. The pandemic enforced changes in work organisation and routines. Increased flexibility, including more patient-oriented delivery of care, and novel means of interorganisational and intraorganisational interactions were perceived as positive by physicians. The pandemic also caused several changes in physicians' psychosocial work environment. Increased workload, information overload, as well as ethical considerations and feelings of uncertainty made the work environment stressful for physicians.\n\nThe COVID-19 pandemic affected the working conditions of physicians in Swedish primary healthcare in numerous ways. The pandemic enforced changes in work organisation and routines for physicians in primary healthcare. Further research is needed to investigate how the pandemic will affect primary healthcare in the longer term. Learning from the pandemic is important because this will not be the last crisis that primary care and its healthcare professionals will face.", "doi": "10.1136/bmjopen-2021-055035", "pmid": "35135771", "labels": {"Category: Public Health": null, "Type: Review": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC8829841"}, {"db": "pii", "key": "bmjopen-2021-055035"}], "notes": [], "created": "2022-02-11T10:35:46.204Z", "modified": "2023-01-13T14:47:38.535Z"}, {"entity": "publication", "iuid": "b84fe457b9754ffea8e728b51a1124de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b84fe457b9754ffea8e728b51a1124de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b84fe457b9754ffea8e728b51a1124de"}}, "title": "Reduced dispensing of prescribed antibiotics during the Covid-19 pandemic has not increased severe complications from common infections.", "authors": [{"family": "Norman", "given": "Christer", "initials": "C"}, {"family": "Svensson", "given": "Mikaela", "initials": "M"}, {"family": "Schmidt", "given": "Ingrid", "initials": "I"}, {"family": "Bergfeldt", "given": "Vendela S", "initials": "VS"}, {"family": "Obeid", "given": "Ragda", "initials": "R"}, {"family": "Ternhag", "given": "Anders", "initials": "A"}, {"family": "Struwe", "given": "Johan L", "initials": "JL"}], "type": "journal article", "published": "2022-02-08", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "252", "issn-l": null}, "abstract": "Sweden has seen an accelerated decline in the number of dispensed antibiotic prescriptions from an already low level during the Covid-19 pandemic. This prompted us to explore whether the decrease in antibiotic prescriptions has reached a critically low level and resulted in an increase in treatment of severe complications from common infections. The aim was to study if the accelerated decrease in antibiotic sales has led to an increase in complications in outpatients with common infections.\n\nA population-based nationwide registry study based on the Swedish Prescribed Drug Register and the National Patient Register.\n\nThe total number of dispensed antibiotic prescriptions decreased by 17% during 2020 compared to 2019. The decrease was most pronounced in younger age groups and for antibiotics targeting respiratory tract infections. The number of hospital admissions and visits to open specialist care due to pneumonia or complications related to otitis, tonsillitis, or sinusitis decreased by 4-44%. Prescriptions and numbers of visits or admissions due to urinary tract infections and skin infections remained largely unchanged compared to previous years.\n\nNo increase in complications due to common bacterial infections could be detected despite an unprecedented decline in dispensed antibiotic prescriptions in outpatient care in 2020. The decrease in dispensed antibiotic prescriptions from pharmacies was probably primarily related to a general decrease in the incidence of respiratory infections due to the recommendations and restrictions implemented to mitigate the Covid-19 pandemic in Sweden. This in return led to fewer doctors' visits and consequently to fewer occasions to prescribe antibiotics, be they warranted or not.", "doi": "10.1186/s12889-022-12692-1", "pmid": "35135517", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-022-12692-1"}], "notes": [], "created": "2022-02-11T10:36:04.989Z", "modified": "2022-02-11T10:36:05.002Z"}, {"entity": "publication", "iuid": "b80e10297ec44011b4e0af10c4361471", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b80e10297ec44011b4e0af10c4361471.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b80e10297ec44011b4e0af10c4361471"}}, "title": "NK cell frequencies, function and correlates to vaccine outcome in BNT162b2 mRNA anti-SARS-CoV-2 vaccinated healthy and immunocompromised individuals.", "authors": [{"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Boulouis", "given": "Caroline", "initials": "C"}, {"family": "Filipovic", "given": "Iva", "initials": "I"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Kammann", "given": "Tobias", "initials": "T"}, {"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Hammer", "given": "Quirin", "initials": "Q"}, {"family": "Strunz", "given": "Benedikt", "initials": "B"}, {"family": "P\u00e9rez Potti", "given": "Andr\u00e9", "initials": "A"}, {"family": "Rivera Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Lange", "given": "Joshua", "initials": "J"}, {"family": "Muvva", "given": "Jagadeeswara Rao", "initials": "JR"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Mielke", "given": "Stephan", "initials": "S"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "S\u00f6derdahl", "given": "Gunnar", "initials": "G"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "Sobkowiak", "given": "Michal J", "initials": "MJ"}, {"family": "Gabarrini", "given": "Giorgio", "initials": "G"}, {"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M"}, {"family": "Alici", "given": "Evren", "initials": "E"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG", "orcid": "0000-0003-0908-7387", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48a59f01e46c41038301a586178e8e2a.json"}}], "type": "journal article", "published": "2022-02-08", "journal": {"title": "Mol Med", "issn": "1528-3658", "volume": "28", "issue": "1", "pages": "20", "issn-l": "1076-1551"}, "abstract": "Adaptive immune responses have been studied extensively in the course of mRNA vaccination against COVID-19. Considerably fewer studies have assessed the effects on innate immune cells. Here, we characterized NK cells in healthy individuals and immunocompromised patients in the course of an anti-SARS-CoV-2 BNT162b2 mRNA prospective, open-label clinical vaccine trial. See trial registration description in notes. Results revealed preserved NK cell numbers, frequencies, subsets, phenotypes, and function as assessed through consecutive peripheral blood samplings at 0, 10, 21, and 35 days following vaccination. A positive correlation was observed between the frequency of NKG2C+ NK cells at baseline (Day 0) and anti-SARS-CoV-2 Ab titers following BNT162b2 mRNA vaccination at Day 35. The present results provide basic insights in regards to NK cells in the context of mRNA vaccination, and have relevance for future mRNA-based vaccinations against COVID-19, other viral infections, and cancer.Trial registration: The current study is based on clinical material from the COVAXID open-label, non-randomized prospective clinical trial registered at EudraCT and clinicaltrials.gov (no. 2021-000175-37). Description: https://clinicaltrials.gov/ct2/show/NCT04780659?term=2021-000175-37&draw=2&rank=1 .", "doi": "10.1186/s10020-022-00443-2", "pmid": "35135470", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null, "Research Area: Vaccine": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "10.1186/s10020-022-00443-2"}, {"db": "ClinicalTrials.gov", "key": "NCT04780659"}], "notes": [], "created": "2022-02-11T10:36:36.455Z", "modified": "2022-02-11T10:37:25.339Z"}, {"entity": "publication", "iuid": "63a75994008f423d81539733ef3c83dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63a75994008f423d81539733ef3c83dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63a75994008f423d81539733ef3c83dd"}}, "title": "Levels and Correlates of Objectively Measured Sedentary Behaviour in Young Children: SUNRISE Study Results from 19 Countries.", "authors": [{"family": "Kariippanon", "given": "Katharina E", "initials": "KE"}, {"family": "Chong", "given": "Kar Hau", "initials": "KH"}, {"family": "Janssen", "given": "Xanne", "initials": "X"}, {"family": "Tomaz", "given": "Simone A", "initials": "SA"}, {"family": "Ribeiro", "given": "Evelyn Hc", "initials": "EH"}, {"family": "Munambah", "given": "Nyaradzai", "initials": "N"}, {"family": "Chan", "given": "Cecilia Hs", "initials": "CH"}, {"family": "Chathurangana", "given": "P W Prasad", "initials": "PWP"}, {"family": "Draper", "given": "Catherine E", "initials": "CE"}, {"family": "El Hamdouchi", "given": "Asmaa", "initials": "A"}, {"family": "Florindo", "given": "Alex A", "initials": "AA"}, {"family": "Guan", "given": "Hongyan", "initials": "H"}, {"family": "Ha", "given": "Amy S", "initials": "AS"}, {"family": "Hossain", "given": "Mohammad Sorowar", "initials": "MS"}, {"family": "Kim", "given": "Dong Hoon", "initials": "DH"}, {"family": "Van Kim", "given": "Thanh", "initials": "T"}, {"family": "Koh", "given": "Denise Cl", "initials": "DC"}, {"family": "L\u00f6f", "given": "Marie", "initials": "M"}, {"family": "Pham", "given": "Bang Nguyen", "initials": "BN"}, {"family": "Poh", "given": "Bee Koon", "initials": "BK"}, {"family": "Reilly", "given": "John J", "initials": "JJ"}, {"family": "Staiano", "given": "Amanda E", "initials": "AE"}, {"family": "Suherman", "given": "Adang", "initials": "A"}, {"family": "Tanaka", "given": "Chiaki", "initials": "C"}, {"family": "Tang", "given": "Hong Kim", "initials": "HK"}, {"family": "Tremblay", "given": "Mark S", "initials": "MS"}, {"family": "Webster", "given": "E Kipling", "initials": "EK"}, {"family": "Wickramasinghe", "given": "V Pujitha", "initials": "VP"}, {"family": "Wong", "given": "Jyh Eiin", "initials": "JE"}, {"family": "Okely", "given": "Anthony D", "initials": "AD"}], "type": "journal article", "published": "2022-02-08", "journal": {"title": "Med Sci Sports Exerc", "issn": "1530-0315", "issn-l": null}, "abstract": "There is a paucity of global data on sedentary behaviour during early childhood. The purpose of this study was to examine how device-measured sedentary behaviour in young children differed across geographically, economically, and socio-demographically diverse populations, in an international sample.\n\nThis multinational, cross-sectional study included data from 1071 3-5-year-old children from 19 countries, collected between 2018 and 2020 (pre-COVID). Sedentary behaviour was measured for three consecutive days using activPAL accelerometers. Sedentary time, sedentary fragmentation and seated transport duration were calculated. Linear mixed models were used to examine the differences in sedentary behaviour variables between sex, country-level income groups, urban/rural settings, and population density.\n\nChildren spent 56% (7.4 hours) of their waking time sedentary. The longest average bout duration was 81.1 \u00b1 45.4 min, and an average of 61.1 \u00b1 50.1 min/day was spent in seated transport. Children from upper-middle-income and high-income countries spent a greater proportion of the day sedentary, accrued more sedentary bouts, had shorter breaks between sedentary bouts, and spent significantly more time in seated transport, than children from low-and lower-middle-income countries. Sex and urban/rural residential setting were not associated with any outcomes. Higher population density was associated with several higher sedentary behaviour measures.\n\nThese data advance our understanding of young children's sedentary behaviour patterns globally. Country income levels and population density appear to be stronger drivers of the observed differences, than sex or rural/urban residential setting.", "doi": "10.1249/MSS.0000000000002886", "pmid": "35142711", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "00005768-900000000-95866"}], "notes": [], "created": "2022-02-11T10:18:27.153Z", "modified": "2022-02-11T10:19:36.106Z"}, {"entity": "publication", "iuid": "9932239cb6834b7085d7a0157811c4ab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9932239cb6834b7085d7a0157811c4ab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9932239cb6834b7085d7a0157811c4ab"}}, "title": "Impact of ADAR-induced editing of minor viral RNA populations on replication and transmission of SARS-CoV-2.", "authors": [{"family": "Ringlander", "given": "Johan", "initials": "J", "orcid": "0000-0002-8483-6504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64f85af7dceb436498422e62f1a98c89.json"}}, {"family": "Fingal", "given": "Joshua", "initials": "J", "orcid": "0000-0001-7305-1026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6f14cbba252f4dbc8521a654ee524919.json"}}, {"family": "Kann", "given": "Hanna", "initials": "H", "orcid": "0000-0003-2014-5437", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01fe861a1bdb43e3a1128c4e53c0c757.json"}}, {"family": "Prakash", "given": "Kasthuri", "initials": "K", "orcid": "0000-0002-7454-6802", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3dddc60b620149019a0be56cf5963d2a.json"}}, {"family": "Rydell", "given": "Gustaf", "initials": "G", "orcid": "0000-0001-8093-2251", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83098d13393c48f0bd17864bac898c3e.json"}}, {"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Martner", "given": "Anna", "initials": "A", "orcid": "0000-0002-6598-5221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c11a2e719c534772a129782bfb60d35c.json"}}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Horal", "given": "Peter", "initials": "P"}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K"}, {"family": "Kann", "given": "Michael", "initials": "M", "orcid": "0000-0002-9589-8022", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7f54042fa8e49d6a7580a8059eaf6e8.json"}}], "type": "journal article", "published": "2022-02-08", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "119", "issue": "6", "issn-l": "0027-8424"}, "abstract": "Adenosine deaminases acting on RNA (ADAR) are RNA-editing enzymes that may restrict viral infection. We have utilized deep sequencing to determine adenosine to guanine (A\u2192G) mutations, signifying ADAR activity, in clinical samples retrieved from 93 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients in the early phase of the COVID-19 pandemic. A\u2192G mutations were detected in 0.035% (median) of RNA residues and were predominantly nonsynonymous. These mutations were rarely detected in the major viral population but were abundant in minor viral populations in which A\u2192G was more prevalent than any other mutation (P < 0.001). The A\u2192G substitutions accumulated in the spike protein gene at positions corresponding to amino acids 505 to 510 in the receptor binding motif and at amino acids 650 to 655. The frequency of A\u2192G mutations in minor viral populations was significantly associated with low viral load (P < 0.001). We additionally analyzed A\u2192G mutations in 288,247 SARS-CoV-2 major (consensus) sequences representing the dominant viral population. The A\u2192G mutations observed in minor viral populations in the initial patient cohort were increasingly detected in European consensus sequences between March and June 2020 (P < 0.001) followed by a decline of these mutations in autumn and early winter (P < 0.001). We propose that ADAR-induced deamination of RNA is a significant source of mutated SARS-CoV-2 and hypothesize that the degree of RNA deamination may determine or reflect viral fitness and infectivity.", "doi": "10.1073/pnas.2112663119", "pmid": "35064076", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2112663119"}], "notes": [], "created": "2022-01-26T10:18:08.767Z", "modified": "2022-01-26T10:18:24.353Z"}, {"entity": "publication", "iuid": "503b3407b0e04a9caad1fea91b464a61", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/503b3407b0e04a9caad1fea91b464a61.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/503b3407b0e04a9caad1fea91b464a61"}}, "title": "Ventilation is not Depressed in Hypoxemic Patients with Acute COVID-19 Infection.", "authors": [{"family": "Kairaitis", "given": "Kristina", "initials": "K", "orcid": "0000-0002-8808-3183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3ae5783acd74a84a18d6725d96088ab.json"}}, {"family": "Harbut", "given": "Piotr", "initials": "P"}, {"family": "Hedenstierna", "given": "Goran", "initials": "G"}, {"family": "Prisk", "given": "G Kim", "initials": "GK"}, {"family": "Farrow", "given": "Catherine E", "initials": "CE"}, {"family": "Amis", "given": "Terence", "initials": "T"}, {"family": "Wagner", "given": "Peter D", "initials": "PD"}, {"family": "Malhotra", "given": "Atul", "initials": "A"}], "type": "journal article", "published": "2022-02-07", "journal": {"title": "Am J Respir Crit Care Med", "issn": "1535-4970", "issn-l": "1073-449X"}, "abstract": null, "doi": "10.1164/rccm.202109-2025LE", "pmid": "35130468", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-08T15:11:07.236Z", "modified": "2022-02-08T15:11:07.289Z"}, {"entity": "publication", "iuid": "4efe1b00c2b046248a5c147fc8aa7401", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4efe1b00c2b046248a5c147fc8aa7401.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4efe1b00c2b046248a5c147fc8aa7401"}}, "title": "The presence of serum anti-SARS-CoV-2 IgA appears to protect primary health care workers from COVID-19.", "authors": [{"family": "Hennings", "given": "Viktoria", "initials": "V", "orcid": "0000-0002-7789-8299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0111566cc8d64377a863765d0f8efa19.json"}}, {"family": "Th\u00f6rn", "given": "Karolina", "initials": "K"}, {"family": "Albinsson", "given": "Sofie", "initials": "S", "orcid": "0000-0003-2038-4286", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f8e41ce25d544cba35b78ddad3352d9.json"}}, {"family": "Lingblom", "given": "Christine", "initials": "C", "orcid": "0000-0003-1284-6911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/656c7e73de8c47eb917ef817a44f716e.json"}}, {"family": "Andersson", "given": "Kerstin", "initials": "K"}, {"family": "Andersson", "given": "Christer", "initials": "C"}, {"family": "J\u00e4rbur", "given": "Katarina", "initials": "K"}, {"family": "Pullerits", "given": "Rille", "initials": "R"}, {"family": "Idorn", "given": "Manja", "initials": "M"}, {"family": "Paludan", "given": "Soren R", "initials": "SR"}, {"family": "Eriksson", "given": "Kristina", "initials": "K"}, {"family": "Wenner\u00e5s", "given": "Christine", "initials": "C"}], "type": "journal article", "published": "2022-02-07", "journal": {"title": "Eur J Immunol", "issn": "1521-4141", "issn-l": null}, "abstract": "The patterns of humoral and cellular responses to SARS-CoV-2 were studied in Swedish primary health care workers (n = 156) for 6 months during the Covid-19 pandemic. Serum IgA and IgG to SARS-CoV-2, T cell proliferation and cytokine secretion, demographic and clinical data, PCR-verified infection, and self-reported symptoms were monitored. The multivariate method OPLS-DA was used to identify immune response patterns coupled to protection from Covid-19. Contracting Covid-19 was associated with SARS-CoV-2-specific neutralizing serum IgG, T cell, interferon-\u03b3 and granzyme B responses to SARS-CoV-2, self-reported typical Covid-19 symptoms, male sex, higher BMI and hypertension. Not contracting Covid-19 was associated with female sex, IgA-dominated or no antibody responses to SARS-CoV-2, airborne allergy, and smoking. The IgG-responders had SARS-CoV-2-specific T cell responses including a cytotoxic CD4+ T cell population expressing CD25, CD38, CD69, CD194, CD279, CTLA-4 and granzyme B. IgA-responders with no IgG response to SARS-CoV-2 constituted 10% of the study population. The IgA responses were partially neutralizing and only seen in individuals who did not succumb to Covid-19. To conclude, serum IgG-dominated responses correlated with T cell responses to SARS-CoV-2 and PCR-confirmed Covid-19, whereas IgA-dominated responses correlated with not contracting the infection. This article is protected by copyright. All rights reserved.", "doi": "10.1002/eji.202149655", "pmid": "35128644", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-08T15:12:06.038Z", "modified": "2022-02-08T15:12:36.409Z"}, {"entity": "publication", "iuid": "76290bd128cb4379b2453a6888629443", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76290bd128cb4379b2453a6888629443.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76290bd128cb4379b2453a6888629443"}}, "title": "Status of Planned and Ongoing Paediatric Trials Investigating COVID-19 Vaccines: A Cross-Sectional Study of Paediatric Clinical Trials Planned in Agreed PIPs and/or Registered in Clinical Trial Databases.", "authors": [{"family": "Christiansen", "given": "Helle", "initials": "H", "orcid": "0000-0003-4893-4622", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1e17e022f4d40a9bc2e3f04e1fb1115.json"}}, {"family": "Thirstrup", "given": "Steffen", "initials": "S"}, {"family": "Hallgreen", "given": "Christine Erikstrup", "initials": "CE"}], "type": "journal article", "published": "2022-02-07", "journal": {"title": "Ther Innov Regul Sci", "issn": "2168-4804", "issn-l": null}, "abstract": "The immune system matures throughout childhood; therefore, evidence about the safety and efficacy of vaccines for the prevention of COVID-19 in the paediatric population is important. Efficacy and safety have not been established for COVID-19 vaccines in a large part of the paediatric population at the time of the initial approval for use in adults. This study aims to provide an overview of planned and ongoing paediatric clinical trials investigating the safety and/or efficacy of COVID-19.\n\nWe identified all paediatric clinical trials investigating the safety and/or efficacy of COVID-19 vaccines in clinicaltrials.gov and clinicaltrialregister.eu, as well as all clinical trials planned in agreed PIPs (Paediatric Investigational Plans) as of 11 June 2021. Information about the study design, the paediatric age groups that they included, and the primary and secondary safety and efficacy outcomes were collected, together with expected timelines for the studies.\n\n21 clinical trials were identified through the clinical trial registries and 19 clinical trials were specified in 6 agreed PIPs, 5 of these trials were also in the trial registers. All PIPs stipulated development of the COVID-19 vaccines for the full paediatric population, with a deferral. The earliest expected completion date of a PIPs is March 2024. The majority (14/21) of registered trials are randomised double-blinded studies. All investigated safety, 20 have a surrogate efficacy outcome (immunogenicity), of these 7 also measure clinical efficacy (COVID-19 infections). 18 studies were initiated, of these, all but one is still ongoing and one in adolescents has been finalised.\n\nEven though several trials have been planned in agreed PIPs, the registered paediatric clinical trials identified are most often not part of a PIP.", "doi": "10.1007/s43441-021-00356-y", "pmid": "35129826", "labels": {"Category: Health": null, "Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s43441-021-00356-y"}], "notes": [], "created": "2022-02-08T15:11:35.057Z", "modified": "2022-02-08T15:11:35.125Z"}, {"entity": "publication", "iuid": "54881f5454a14988b68f80c0062998ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54881f5454a14988b68f80c0062998ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54881f5454a14988b68f80c0062998ff"}}, "title": "Corrigendum to \"Presymptomatic viral shedding and infective ability of SARS-CoV-2; a case report\" <[Heliyon Volume 7, Issue 2, February 2021, Article e06328]>.", "authors": [{"family": "Nissen", "given": "Karolina", "initials": "K"}, {"family": "Hagbom", "given": "Marie", "initials": "M"}, {"family": "Krambrich", "given": "Janina", "initials": "J"}, {"family": "Akaberi", "given": "Dario", "initials": "D"}, {"family": "Sharma", "given": "Sumit", "initials": "S"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Svensson", "given": "Lennart", "initials": "L"}, {"family": "Bondeson", "given": "K\u00e5re", "initials": "K"}, {"family": "Salaneck", "given": "Erik", "initials": "E"}], "type": "published erratum", "published": "2022-02-05", "journal": {"title": "Heliyon", "issn": "2405-8440", "pages": "e08906", "issn-l": null}, "abstract": "[This corrects the article DOI: 10.1016/j.heliyon.2021.e06328.].", "doi": "10.1016/j.heliyon.2022.e08906", "pmid": "35155841", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(22)00194-3"}, {"db": "pmc", "key": "PMC8816836"}], "notes": [], "created": "2022-02-17T06:12:14.171Z", "modified": "2022-02-17T06:12:14.177Z"}, {"entity": "publication", "iuid": "40c1407d4e1d4e958520c51db97cdfc0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/40c1407d4e1d4e958520c51db97cdfc0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/40c1407d4e1d4e958520c51db97cdfc0"}}, "title": "Anti-SARS-CoV-2 Action of 5\u03b1-Reductase Inhibitors May be Mediated by Dehydroepiandrosterone.", "authors": [{"family": "Papadopoulos", "given": "Konstantinos I", "initials": "KI", "orcid": "0000-0003-0041-7853", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/57c63fdf7036465686e79794a5107544.json"}}, {"family": "Papadopoulou", "given": "Alexandra", "initials": "A", "orcid": "0000-0002-7488-8271", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9000ff7673bc4d35bde729ce8829ab5d.json"}}, {"family": "Sutheesophon", "given": "Warachaya", "initials": "W", "orcid": "0000-0002-1823-3852", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fab7d634e454e24989da629eafe21dc.json"}}, {"family": "Aw", "given": "Tar-Choon", "initials": "TC", "orcid": "0000-0002-7814-8836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f95d6a8535d41fbb7b5cf40fb091205.json"}}], "type": "letter", "published": "2022-02-04", "journal": {"title": "J Urol", "issn": "1527-3792", "pages": "101097JU0000000000002469", "issn-l": null}, "abstract": null, "doi": "10.1097/JU.0000000000002469", "pmid": "35119308", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2022-02-06T16:45:38.320Z", "modified": "2022-02-08T15:18:26.096Z"}, {"entity": "publication", "iuid": "18b782025bf84c03a2034b37e4eb7d15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18b782025bf84c03a2034b37e4eb7d15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18b782025bf84c03a2034b37e4eb7d15"}}, "title": "RT-PCR cycle threshold value in combination with visual scoring of chest computed tomography at hospital admission predicts outcome in COVID-19.", "authors": [{"family": "Ingberg", "given": "Edvin", "initials": "E"}, {"family": "Ahlstrand", "given": "Erik", "initials": "E"}, {"family": "Cajander", "given": "Per", "initials": "P"}, {"family": "L\u00f6f", "given": "Erika", "initials": "E"}, {"family": "Sundqvist", "given": "Martin", "initials": "M"}, {"family": "Wegener", "given": "Matthias", "initials": "M"}, {"family": "Lid\u00e9n", "given": "Mats", "initials": "M", "orcid": "0000-0002-1346-1450", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2a16a7027194ab9a32ab284641491a4.json"}}, {"family": "Cajander", "given": "Sara", "initials": "S"}], "type": "journal article", "published": "2022-02-03", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "pages": "1-10", "issn-l": "2374-4235"}, "abstract": "COVID-19 has a most variable prognosis. Several risk factors for an unfavourable outcome have been identified including extensive lung involvement on chest CT and high viral load estimated by RT-PCR cycle threshold (Ct) values. We investigated Ct value for outcome prediction, relation between Ct value and extent of lung involvement on chest CT and the combination of Ct value and chest CT lung involvement to predict outcome in COVID-19.\n\nPopulation-based retrospective study on all patients (n = 286) hospitalised for COVID-19 in \u00d6rebro Region, Sweden, between 1 March and 31 August 2020. Nasopharyngeal samples and chest CT at hospital admission were evaluated in relation to outcome of COVID-19.\n\nBoth Ct value and chest CT lung involvement were independently associated with risk for ICU admission or death. Lung involvement was superior as a single parameter, but addition of Ct value increased the prediction performance. Ct value was especially useful to identify patients with high risk for severe disease despite limited lung involvement.\n\nThe addition of RT-PCR Ct value to the assessment of lung involvement on chest CT adds valuable prognostic information in COVID-19. We believe that this information can be used to support clinical decision-making when managing COVID-19 patients.", "doi": "10.1080/23744235.2022.2035428", "pmid": "35114897", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-06T16:47:42.595Z", "modified": "2022-02-06T16:47:42.658Z"}, {"entity": "publication", "iuid": "29ba0134e3e54eb69d2f4b296a8d79b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/29ba0134e3e54eb69d2f4b296a8d79b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/29ba0134e3e54eb69d2f4b296a8d79b3"}}, "title": "ESCMID guidelines on testing for SARS-CoV-2 in asymptomatic individuals to prevent transmission in the healthcare setting.", "authors": [{"family": "Carrara", "given": "Elena", "initials": "E"}, {"family": "Ong", "given": "David S Y", "initials": "DSY"}, {"family": "Hussein", "given": "Khetam", "initials": "K"}, {"family": "Keske", "given": "Siran", "initials": "S"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}, {"family": "Presterl", "given": "Elisabeth", "initials": "E"}, {"family": "Tsioutis", "given": "Constantinos", "initials": "C"}, {"family": "Tschudin-Sutter", "given": "Sarah", "initials": "S"}, {"family": "Tacconelli", "given": "Evelina", "initials": "E"}], "type": "journal article", "published": "2022-02-03", "journal": {"title": "Clin Microbiol Infect", "issn": "1469-0691", "issn-l": null}, "abstract": "This guideline addresses the indications for direct testing of SARS-CoV-2 in asymptomatic individuals in healthcare facilities with the aim to prevent SARS-CoV-2 transmissions in these settings. The benefit of testing asymptomatic individuals to create a safe environment for patients and healthcare workers must be weighed against potential unintended consequences including delaying necessary treatments due to false positive results and lower quality of care due to strict isolation measures.\n\nA total of 9 PICOs on the topic of testing asymptomatic individuals was selected by the panel members. Subsequently, a literature search for existing guidelines and systematic reviews was performed on Pubmed, Epistemonikos, and RecMap using relevant filters available in each database. Data about article/recommendation type, setting, target population, intervention, and quality of the evidence were extracted. Credibility of the systematic reviews were evaluated using the AMSTAR-tool, and level of agreement with available recommendation was evaluated with the AGREE II-score. Because the evidence available from systematic reviews was deemed insufficiently updated to formulate relevant recommendations, an additional search targeting relevant guidance documents from major public health institutions and original studies was performed. Provisional recommendations were discussed via web conferences until agreement was reached and final recommendations was formulated according to the GRADE approach. Questions addressed by the guideline and recommendations: Recommendations were formulated regarding systematic testing in asymptomatic individuals upon admission to a healthcare setting, during hospital stay, prior to elective procedures, and prior to scheduled non-surgical procedures. Moreover, recommendations regarding testing of asymptomatic visitors, personal caregivers and healthcare workers in healthcare facilities were presented. Also, recommendations were given on contact tracing in asymptomatic patients or healthcare workers, and the possibility of a negative screening test to shorten the quarantine period. Furthermore, if applicable, recommendations were specified to transmission rate and vaccination coverage.", "doi": "10.1016/j.cmi.2022.01.007", "pmid": "35124258", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(22)00030-1"}], "notes": [], "created": "2022-02-08T15:16:03.487Z", "modified": "2022-02-08T15:16:03.501Z"}, {"entity": "publication", "iuid": "4a81b2ae9bc84e28a41303f76a7ba873", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4a81b2ae9bc84e28a41303f76a7ba873.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4a81b2ae9bc84e28a41303f76a7ba873"}}, "title": "Clinical and histology features as predictor of severity of mucormycosis in post-COVID-19 patients: An experience from a rural tertiary setting in Central India.", "authors": [{"family": "Jain", "given": "Kavita", "initials": "K", "orcid": "0000-0002-2024-9861", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/765cbc86e8fc41b3818f457b82bcc442.json"}}, {"family": "Surana", "given": "Akshay", "initials": "A"}, {"family": "Choudhary", "given": "Tej Singh", "initials": "TS"}, {"family": "Vaidya", "given": "Sudhakar", "initials": "S"}, {"family": "Nandedkar", "given": "Shirish", "initials": "S"}, {"family": "Purohit", "given": "Manju", "initials": "M", "orcid": "0000-0001-5385-7305", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4b7ea75e9964d40b1d34c569f4197f1.json"}}], "type": "journal article", "published": "2022-02-03", "journal": {"title": "SAGE Open Med", "issn": "2050-3121", "volume": "10", "pages": "20503121221074785", "issn-l": null}, "abstract": "An upsurge in cases of rhinosinusitis with or without associated orbital and/or cerebral involvement by mucormycosis has been observed in post-COVID-19 patients. Our objective is to evaluate the clinical and histopathology features of these patients to determine the severity and develop a scoring on the extent on tissue invasion.\n\nWe prospectively enrolled and analyzed 95 post-COVID-19 patients who presented with the invasive mucormycosis of the head and neck region. Clinical and histology details were noted in predesigned forms. Various histology variables were graded from I to III to propose a scoring system for the severity of the disease.\n\nMucormycosis was common in males with a mean age of 46.8 \u00b1 11 years. Facial pain was the most common presenting complaint and 77% of the patients were diabetic. Most cases (n = 59) showed a moderate degree of neutrophilic infiltrate with \u2a7e50% tissue necrosis and angioinvasion in three or more vessels with a fungal load of 2+/3+. Histology severity grade III was observed in patients who died from cerebral mucormycosis (n = 3) and septicemia (n = 2) and in patients who had undergone orbital exenteration (n = 6).\n\nThe histopathology and severity score classification was directly correlated with the outcome of the patients. Further evaluation and a larger study will help to validate the proposed scoring for its clinical use in all forms and causes of mucormycosis.", "doi": "10.1177/20503121221074785", "pmid": "35140976", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1177_20503121221074785"}, {"db": "pmc", "key": "PMC8819781"}], "notes": [], "created": "2022-02-11T10:23:44.934Z", "modified": "2022-02-11T10:23:45.065Z"}, {"entity": "publication", "iuid": "30b1695564e547bc94c8255556c21995", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/30b1695564e547bc94c8255556c21995.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/30b1695564e547bc94c8255556c21995"}}, "title": "COVID-19 vaccination in the setting of mastocytosis - Pfizer-BioNTech mRNA vaccine is safe and well-tolerated.", "authors": [{"family": "Lazarinis", "given": "Nikolaos", "initials": "N"}, {"family": "Bossios", "given": "Apostolos", "initials": "A"}, {"family": "G\u00fclen", "given": "Theo", "initials": "T"}], "type": "journal article", "published": "2022-02-02", "journal": {"title": "J Allergy Clin Immunol Pract", "issn": "2213-2201", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jaip.2022.01.037", "pmid": "35123098", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2213-2198(22)00117-9"}, {"db": "pmc", "key": "PMC8810433"}], "notes": [], "created": "2022-02-06T16:44:49.496Z", "modified": "2022-02-08T15:17:54.397Z"}, {"entity": "publication", "iuid": "f7f150de5b4244bc8f2c07f33b2b57ab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7f150de5b4244bc8f2c07f33b2b57ab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7f150de5b4244bc8f2c07f33b2b57ab"}}, "title": "Analytical observational study evaluating global pandemic preparedness and the effectiveness of early COVID-19 responses in Ethiopia, Nigeria, Singapore, South Korea, Sweden, Taiwan, UK and USA.", "authors": [{"family": "Nikolaeva", "given": "Alexandra", "initials": "A", "orcid": "0000-0001-9876-8250", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72b6128366414c6abb9a9a53c6fe605b.json"}}, {"family": "Versnel", "given": "Jenny", "initials": "J"}], "type": "journal article", "published": "2022-02-02", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "2", "pages": "e053374", "issn-l": "2044-6055"}, "abstract": "An analysis of early country-specific COVID-19 strategies and the impact of policies, healthcare resources and cultural influences on their effectiveness.\n\nAnalytical observational study.\n\nUSA, UK, Sweden, South Korea, Singapore, Taiwan, Ethiopia and Nigeria.\n\nOxCGRT indices were used to quantify variations in governments' responses, and effectiveness was measured by the number of deaths as a proportion of the population. Hofstede's cultural dimensions, and the availability of healthcare resources, were analysed for their potential impact on effectiveness.\n\nEffective strategies reflect factors such as speed of governmental intervention, cultural norms, population demographics and available resources. While biases, confounders and lack of data at the beginning of the pandemic make inferences challenging, publicly available data suggest that South Korea, Singapore and Taiwan were most successful through rapid identification and isolation of cases, and effective contact tracing systems.\n\nThe rapid spread of the highly transmissible SARS-CoV-2 virus took many countries by surprise and the delayed global response contributed to the severity of the COVID-19 pandemic. The speed at which strategies were implemented is highly correlated to the number of deaths. Factors such as cultural norms and healthcare resources impact effectiveness significantly, implying that implementation of a global 'one size fits all' approach is challenging. Global preparedness should focus on effective surveillance and preparedness strategies to enable timely identification and containment of future threats.", "doi": "10.1136/bmjopen-2021-053374", "pmid": "35110318", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-053374"}, {"db": "pmc", "key": "PMC8811275"}], "notes": [], "created": "2022-02-06T16:49:10.101Z", "modified": "2022-02-06T16:49:10.157Z"}, {"entity": "publication", "iuid": "1e0441ac55c94d91855aaf702ae739a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1e0441ac55c94d91855aaf702ae739a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1e0441ac55c94d91855aaf702ae739a1"}}, "title": "Allergies and COVID-19 vaccines: An ENDA/EAACI Position paper.", "authors": [{"family": "Barbaud", "given": "Annick", "initials": "A"}, {"family": "Garvey", "given": "Lene Heise", "initials": "LH", "orcid": "0000-0002-7777-4501", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77c921b2de6f4d9ea19c1cfea043c502.json"}}, {"family": "Arcolaci", "given": "Alessandra", "initials": "A"}, {"family": "Brockow", "given": "Knut", "initials": "K", "orcid": "0000-0002-2775-3681", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91fc8e9e37ab420fbf2a18c3eb063b71.json"}}, {"family": "Mori", "given": "Francesca", "initials": "F"}, {"family": "Mayorga", "given": "Cristobalina", "initials": "C"}, {"family": "Bonadonna", "given": "Patrizia", "initials": "P", "orcid": "0000-0002-5703-5314", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/220301cdd99d401095b70eadd8cb4b30.json"}}, {"family": "Atanaskovic-Markovic", "given": "Marina", "initials": "M", "orcid": "0000-0003-1354-6072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83efadf622ac4e8f975a4f7edddcda71.json"}}, {"family": "Moral", "given": "Luis", "initials": "L", "orcid": "0000-0002-7066-6073", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e60105059bd74801b78fba9826622c0c.json"}}, {"family": "Zanoni", "given": "Giovanna", "initials": "G"}, {"family": "Pagani", "given": "Mauro", "initials": "M", "orcid": "0000-0002-0591-5416", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c1524ff0274c68a642c8a82c5a63fb.json"}}, {"family": "Soria", "given": "Ang\u00e8le", "initials": "A", "orcid": "0000-0002-8726-6658", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/38633c9e786c45118b3192482cee8436.json"}}, {"family": "Jo\u0161t", "given": "Maja", "initials": "M"}, {"family": "Caubet", "given": "Jean-Christoph", "initials": "JC", "orcid": "0000-0001-5006-5724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8db20fc3c6842688b8f3be3f8742ef6.json"}}, {"family": "Abreu", "given": "Carmo", "initials": "C"}, {"family": "Al-Ahmad", "given": "Mona", "initials": "M"}, {"family": "Alvarez-Perea", "given": "Alberto", "initials": "A", "orcid": "0000-0001-7417-7309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e765e633592843ac887bbf59b533a8be.json"}}, {"family": "Bavbek", "given": "Sevim", "initials": "S", "orcid": "0000-0002-7884-0830", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd4648dd8218433d9891c4a100cd6495.json"}}, {"family": "Benedetta", "given": "Biagioni", "initials": "B"}, {"family": "Beatrice", "given": "Bilo M", "initials": "BM"}, {"family": "Blanca-L\u00f3pez", "given": "Natalia", "initials": "N", "orcid": "0000-0002-1492-9887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb6e84df33bc4b608b0a512b017d2a95.json"}}, {"family": "Bogas Herrera", "given": "G\u00e1dor", "initials": "G"}, {"family": "Buonomo", "given": "Alessandro", "initials": "A"}, {"family": "Calogiuri", "given": "Gianfranco", "initials": "G"}, {"family": "Carli", "given": "Giulia", "initials": "G", "orcid": "0000-0001-6400-9205", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1512d6895f1342d0aef6d2d669e5b638.json"}}, {"family": "Cernadas", "given": "Josefina", "initials": "J"}, {"family": "Cortellini", "given": "Gabriele", "initials": "G"}, {"family": "Celik", "given": "G\u00fclfem", "initials": "G", "orcid": "0000-0001-8654-513X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0bed9b33057341268ed0b5f0c00fc4db.json"}}, {"family": "Demir", "given": "Semra", "initials": "S"}, {"family": "Do\u00f1a", "given": "Inmaculada", "initials": "I", "orcid": "0000-0002-5309-4878", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32509c221e7e473faf9d8170af50cd19.json"}}, {"family": "Dursun Adile", "given": "Berna", "initials": "B"}, {"family": "Eberlein", "given": "Bernadette", "initials": "B", "orcid": "0000-0003-4509-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c7c092fc4c042f19a95fb904663bb7e.json"}}, {"family": "Emilia", "given": "Faria", "initials": "F"}, {"family": "Bryan", "given": "Fernandes", "initials": "F"}, {"family": "Garcez", "given": "Tomaz", "initials": "T"}, {"family": "Garcia-Nunez", "given": "Ignacio", "initials": "I"}, {"family": "Gawlik", "given": "Radoslaw", "initials": "R"}, {"family": "Gelincik", "given": "Asli", "initials": "A", "orcid": "0000-0002-3524-9952", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/266358f8a2974b5aa5fe91c75dcb9fcf.json"}}, {"family": "Gomes", "given": "Eva", "initials": "E"}, {"family": "Gooi", "given": "Jimmy Hc", "initials": "JH"}, {"family": "Grosber", "given": "Martine", "initials": "M"}, {"family": "G\u00fclen", "given": "Theo", "initials": "T"}, {"family": "Hacard", "given": "Florence", "initials": "F"}, {"family": "Cyrille", "given": "Hoarau", "initials": "H"}, {"family": "Janson", "given": "Christer", "initials": "C"}, {"family": "Johnston", "given": "Sebastian L", "initials": "SL"}, {"family": "Joerg", "given": "Lukas", "initials": "L", "orcid": "0000-0003-1512-4279", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e3fbf9104f74debab2cf215b242ad9a.json"}}, {"family": "Kepil \u00d6zdemir", "given": "Se\u00e7il", "initials": "S", "orcid": "0000-0003-2688-9867", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92809dfd8abd4491a916e5eb028c0c63.json"}}, {"family": "Klimek", "given": "Ludger", "initials": "L", "orcid": "0000-0002-2455-0192", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/faa1bbfb4833469db8c698a323958747.json"}}, {"family": "Ko\u0161nik", "given": "Mitja", "initials": "M", "orcid": "0000-0002-4701-7374", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27bf299d920c43559b858bdf014078be.json"}}, {"family": "Kowalski", "given": "Marek L", "initials": "ML"}, {"family": "Kuyucu", "given": "Semanur", "initials": "S"}, {"family": "Kvedariene", "given": "Violeta", "initials": "V"}, {"family": "Julio Laguna", "given": "Jose", "initials": "J"}, {"family": "Carla", "given": "Lombardo", "initials": "L"}, {"family": "Marinho", "given": "Susana", "initials": "S"}, {"family": "Merk", "given": "Hans", "initials": "H"}, {"family": "Meucci", "given": "Elisa", "initials": "E"}, {"family": "Morisset", "given": "Martine", "initials": "M", "orcid": "0000-0002-4028-703X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20f59dfbd72747db87c4a767899e6f82.json"}}, {"family": "Munoz-Cano", "given": "Rosa", "initials": "R", "orcid": "0000-0001-8566-8285", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4775ffb585f64514b502f7340b5d097e.json"}}, {"family": "Murzilli", "given": "Francesco", "initials": "F"}, {"family": "Nakonechna", "given": "Alla", "initials": "A"}, {"family": "Popescu", "given": "Florin-Dan", "initials": "FD"}, {"family": "Porebski", "given": "Grzegorz", "initials": "G", "orcid": "0000-0002-6146-0188", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d1ad79789ab45a5a022e7921f2655cd.json"}}, {"family": "Radice", "given": "Anna", "initials": "A"}, {"family": "Regateiro", "given": "Frederico S", "initials": "FS"}, {"family": "R\u00f6ckmann", "given": "Heike", "initials": "H"}, {"family": "Romano", "given": "Antonino", "initials": "A"}, {"family": "Sargur", "given": "Ravishankar", "initials": "R", "orcid": "0000-0002-8535-630X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b4169bbedcf4f6785f2077772d123ce.json"}}, {"family": "Sastre", "given": "Joaquin", "initials": "J"}, {"family": "Kathrin", "given": "Scherer Hofmeier", "initials": "SH"}, {"family": "Lenka", "given": "Sedl\u00e1\u010dkov\u00e1", "initials": "S"}, {"family": "Marta", "given": "Sobotkova", "initials": "S", "orcid": "0000-0003-3864-8008", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ca2adee8d1f4c94a69666cff8c20729.json"}}, {"family": "Ingrid", "given": "Terreehorst", "initials": "T"}, {"family": "Treudler", "given": "Regina", "initials": "R"}, {"family": "Walusiak-Skorupa", "given": "Jolanta", "initials": "J"}, {"family": "Wedi", "given": "Bettina", "initials": "B", "orcid": "0000-0002-9868-6308", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9715672937a4be5aad8eced12db8722.json"}}, {"family": "W\u00f6hrl", "given": "Stefan", "initials": "S", "orcid": "0000-0002-6324-0007", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89ec6d306f3f4fd98d35536a513277b8.json"}}, {"family": "Zidarn", "given": "Mihael", "initials": "M"}, {"family": "Zuberbier", "given": "Torsten", "initials": "T", "orcid": "0000-0002-1466-8875", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7dc091f64a240fd8fb6443292b812c6.json"}}, {"family": "Agache", "given": "Ioana", "initials": "I", "orcid": "0000-0001-7994-364X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25d9598f74414a38a868c2bcf545e94d.json"}}, {"family": "Torres", "given": "Maria J", "initials": "MJ", "orcid": "0000-0001-5228-471X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6558e75ee5494904a135d8cfe05c1927.json"}}], "type": "journal article", "published": "2022-02-02", "journal": {"title": "Allergy", "issn": "1398-9995", "issn-l": "0105-4538"}, "abstract": "Anaphylaxis, which is rare, has been reported after COVID 19 vaccination, but its management is not standardized.\n\nMembers of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interested in drug allergy participated in an online questionnaire on pre-vaccination screening and management of allergic reactions to COVID-19 vaccines, and literature was analysed.\n\nNo death due to anaphylaxis to COVID-19 vaccines has been confirmed in scientific literature. Potential allergens, polyethylene glycol (PEG), polysorbate and tromethamine, are excipients. The authors propose allergy evaluation of persons with the following histories: 1-anaphylaxis to injectable drug or vaccine containing PEG or derivatives; 2- anaphylaxis to oral/topical PEG containing products; 3-recurrent anaphylaxis of unknown cause; 4-suspected or confirmed allergy to any mRNA vaccine, 5-confirmed allergy to PEG or derivatives. We recommend a prick-to-prick skin test with the left over solution in the suspected vaccine vial to avoid waste. Prick test panel should include PEG 4000 or 3500, PEG 2000 and polysorbate 80. The value of in vitro test is arguable.\n\nThese recommendations, will lead to a better knowledge of the management and mechanisms involved in anaphylaxis to COVID-19 vaccines and enable more people with history of allergy to be vaccinated.", "doi": "10.1111/all.15241", "pmid": "35112371", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-06T16:47:24.640Z", "modified": "2022-02-06T16:47:25.500Z"}, {"entity": "publication", "iuid": "43321e1f33754836912d2d42cb4e6111", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/43321e1f33754836912d2d42cb4e6111.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/43321e1f33754836912d2d42cb4e6111"}}, "title": "Self-reported COVID-19 vaccine hesitancy and uptake among participants from different racial and ethnic groups in the United States and United Kingdom.", "authors": [{"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Merino", "given": "Jordi", "initials": "J", "orcid": "0000-0001-8312-1438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12ab049914a542b39affcfb4196861d2.json"}}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Lo", "given": "Chun-Han", "initials": "CH", "orcid": "0000-0001-8202-4513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a0d9111318f4084b64f47b5b56c8c85.json"}}, {"family": "Kwon", "given": "Sohee", "initials": "S", "orcid": "0000-0002-4201-9522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/850aeda246cd44e88071b97d54b358b5.json"}}, {"family": "Wang", "given": "Kai", "initials": "K"}, {"family": "Graham", "given": "Mark S", "initials": "MS"}, {"family": "Polidori", "given": "Lorenzo", "initials": "L"}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874802ae65824a90ba50eabdeabb8356.json"}}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Anyane-Yeboa", "given": "Adjoa", "initials": "A"}, {"family": "Astley", "given": "Christina M", "initials": "CM", "orcid": "0000-0002-5063-8470", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98ce30ec7a7d45389d75aba2defce392.json"}}, {"family": "Warner", "given": "Erica T", "initials": "ET"}, {"family": "Hu", "given": "Christina Y", "initials": "CY"}, {"family": "Selvachandran", "given": "Somesh", "initials": "S"}, {"family": "Davies", "given": "Richard", "initials": "R", "orcid": "0000-0003-2050-3994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b82cc92615f462d9af0153a6fb94fde.json"}}, {"family": "Nash", "given": "Denis", "initials": "D"}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74cf1f7094744ee289fa5df041e7cb5b.json"}}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-7284-6767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeefbf47fd384d5390109fe1a903bd18.json"}}, {"family": "COPE Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2022-02-01", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "636", "issn-l": "2041-1723"}, "abstract": "Worldwide, racial and ethnic minorities have been disproportionately impacted by COVID-19 with increased risk of infection, its related complications, and death. In the initial phase of population-based vaccination in the United States (U.S.) and United Kingdom (U.K.), vaccine hesitancy may result in differences in uptake. We performed a cohort study among U.S. and U.K. participants who volunteered to take part in the smartphone-based COVID Symptom Study (March 2020-February 2021) and used logistic regression to estimate odds ratios of vaccine hesitancy and uptake. In the U.S. (n = 87,388), compared to white participants, vaccine hesitancy was greater for Black and Hispanic participants and those reporting more than one or other race. In the U.K. (n = 1,254,294), racial and ethnic minority participants showed similar levels of vaccine hesitancy to the U.S. However, associations between participant race and ethnicity and levels of vaccine uptake were observed to be different in the U.S. and the U.K. studies. Among U.S. participants, vaccine uptake was significantly lower among Black participants, which persisted among participants that self-reported being vaccine-willing. In contrast, statistically significant racial and ethnic disparities in vaccine uptake were not observed in the U.K sample. In this study of self-reported vaccine hesitancy and uptake, lower levels of vaccine uptake in Black participants in the U.S. during the initial vaccine rollout may be attributable to both hesitancy and disparities in access.", "doi": "10.1038/s41467-022-28200-3", "pmid": "35105869", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-022-28200-3"}], "notes": [], "created": "2022-02-06T16:51:03.679Z", "modified": "2022-02-06T16:51:03.864Z"}, {"entity": "publication", "iuid": "2f8eb9d568d649e398c46824757736cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2f8eb9d568d649e398c46824757736cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2f8eb9d568d649e398c46824757736cc"}}, "title": "Conditionality of COVID-19 vaccine acceptance in European countries.", "authors": [{"family": "Heyerdahl", "given": "Leonardo W", "initials": "LW"}, {"family": "Vray", "given": "Muriel", "initials": "M"}, {"family": "Lana", "given": "Benedetta", "initials": "B"}, {"family": "Tvardik", "given": "Nastassia", "initials": "N"}, {"family": "Gobat", "given": "Nina", "initials": "N"}, {"family": "Wanat", "given": "Marta", "initials": "M"}, {"family": "Tonkin-Crine", "given": "Sarah", "initials": "S"}, {"family": "Anthierens", "given": "Sibyl", "initials": "S"}, {"family": "Goossens", "given": "Herman", "initials": "H"}, {"family": "Giles-Vernick", "given": "Tamara", "initials": "T"}], "type": "journal article", "published": "2022-02-01", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null}, "abstract": "The COVID-19 vaccine rollout has offered a powerful preventive measure to help control SARS-CoV-2 transmission. Nevertheless, long-standing public hesitation around vaccines heightened concerns that vaccine coverage would not achieve desired public health impacts, particularly in light of more contagious variants. This cross-sectional survey was conducted online just before the European vaccine rollout in December 2020 among 7000 respondents (aged 18-65) in Belgium, France, Germany, Italy, Spain, Sweden, and Ukraine. The survey included open text boxes for fuller explanation of responses. Overall, 56.9% of respondents would accept a COVID-19 vaccine, 19.0% would not, and 24.1% did not know or preferred not to say. By country, between 44% (France) and 66% (Italy) of respondents would accept a COVID-19 vaccine. Respondents expressed conditionality in open responses, voicing concerns about vaccine safety and mistrust of authorities. We highlight lessons learned about the dynamism of vaccine conditionality and persistence of safety concerns.", "doi": "10.1016/j.vaccine.2022.01.054", "pmid": "35125225", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(22)00099-8"}], "notes": [], "created": "2022-02-08T15:15:41.099Z", "modified": "2022-02-08T15:15:41.113Z"}, {"entity": "publication", "iuid": "d4948847193e46a89360c70bc03170dc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4948847193e46a89360c70bc03170dc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4948847193e46a89360c70bc03170dc"}}, "title": "Variations in the financial impact of the COVID-19 pandemic across 5 continents: A cross-sectional, individual level analysis.", "authors": [{"family": "Khetan", "given": "Aditya K", "initials": "AK"}, {"family": "Yusuf", "given": "Salim", "initials": "S"}, {"family": "Lopez-Jaramillo", "given": "Patricio", "initials": "P"}, {"family": "Szuba", "given": "Andrzej", "initials": "A"}, {"family": "Orlandini", "given": "Andres", "initials": "A"}, {"family": "Mat-Nasir", "given": "Nafiza", "initials": "N"}, {"family": "Oguz", "given": "Aytekin", "initials": "A"}, {"family": "Gupta", "given": "Rajeev", "initials": "R"}, {"family": "Avezum", "given": "\u00c1lvaro", "initials": "\u00c1"}, {"family": "Rosnah", "given": "Ismail", "initials": "I"}, {"family": "Poirier", "given": "Paul", "initials": "P"}, {"family": "Teo", "given": "Koon K", "initials": "KK"}, {"family": "Wielgosz", "given": "Andreas", "initials": "A"}, {"family": "Lear", "given": "Scott A", "initials": "SA"}, {"family": "Palileo-Villanueva", "given": "Lia M", "initials": "LM"}, {"family": "Ser\u00f3n", "given": "Pamela", "initials": "P"}, {"family": "Chifamba", "given": "Jephat", "initials": "J"}, {"family": "Rangarajan", "given": "Sumathy", "initials": "S"}, {"family": "Mushtaha", "given": "Maha", "initials": "M"}, {"family": "Mohan", "given": "Deepa", "initials": "D"}, {"family": "Yeates", "given": "Karen", "initials": "K"}, {"family": "McKee", "given": "Martin", "initials": "M"}, {"family": "Mony", "given": "Prem K", "initials": "PK"}, {"family": "Walli-Attaei", "given": "Marjan", "initials": "M"}, {"family": "Khansaheb", "given": "Hamda", "initials": "H"}, {"family": "Rosengren", "given": "Annika", "initials": "A"}, {"family": "Alhabib", "given": "Khalid F", "initials": "KF"}, {"family": "Kruger", "given": "Iolanth\u00e9 M", "initials": "IM"}, {"family": "Paucar", "given": "Mar\u00eda-Jos\u00e9", "initials": "MJ"}, {"family": "Mirrakhimov", "given": "Erkin", "initials": "E"}, {"family": "Assembekov", "given": "Batyrbek", "initials": "B"}, {"family": "Leong", "given": "Darryl P", "initials": "DP"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": "44", "pages": "101284", "issn-l": null}, "abstract": "COVID-19 has caused profound socio-economic changes worldwide. However, internationally comparative data regarding the financial impact on individuals is sparse. Therefore, we conducted a survey of the financial impact of the pandemic on individuals, using an international cohort that has been well-characterized prior to the pandemic.\n\nBetween August 2020 and September 2021, we surveyed 24,506 community-dwelling participants from the Prospective Urban-Rural Epidemiology (PURE) study across high (HIC), upper middle (UMIC)-and lower middle (LMIC)-income countries. We collected information regarding the impact of the pandemic on their self-reported personal finances and sources of income.\n\nOverall, 32.4% of participants had suffered an adverse financial impact, defined as job loss, inability to meet financial obligations or essential needs, or using savings to meet financial obligations. 8.4% of participants had lost a job (temporarily or permanently); 14.6% of participants were unable to meet financial obligations or essential needs at the time of the survey and 16.3% were using their savings to meet financial obligations. Participants with a post-secondary education were least likely to be adversely impacted (19.6%), compared with 33.4% of those with secondary education and 33.5% of those with pre-secondary education. Similarly, those in the highest wealth tertile were least likely to be financially impacted (26.7%), compared with 32.5% in the middle tertile and 30.4% in the bottom tertile participants. Compared with HICs, financial impact was greater in UMIC [odds ratio of 2.09 (1.88-2.33)] and greatest in LMIC [odds ratio of 16.88 (14.69-19.39)]. HIC participants with the lowest educational attainment suffered less financial impact (15.1% of participants affected) than those with the highest education in UMIC (22.0% of participants affected). Similarly, participants with the lowest education in UMIC experienced less financial impact (28.3%) than those with the highest education in LMIC (45.9%). A similar gradient was seen across country income categories when compared by pre-pandemic wealth status.\n\nThe financial impact of the pandemic differs more between HIC, UMIC, and LMIC than between socio-economic categories within a country income level. The most disadvantaged socio-economic subgroups in HIC had a lower financial impact from the pandemic than the most advantaged subgroup in UMIC, with a similar disparity seen between UMIC and LMIC. Continued high levels of infection will exacerbate financial inequity between countries and hinder progress towards the sustainable development goals, emphasising the importance of effective measures to control COVID-19 and, especially, ensuring high vaccine coverage in all countries.\n\nFunding for this study was provided by the Canadian Institutes of Health Research and the International Development Research Centre.", "doi": "10.1016/j.eclinm.2022.101284", "pmid": "35106472", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(22)00014-1"}, {"db": "pmc", "key": "PMC8794545"}], "notes": [], "created": "2022-02-06T16:50:23.395Z", "modified": "2022-02-06T16:50:23.408Z"}, {"entity": "publication", "iuid": "cd6a3a5d47334aa6a79c66e514409e4e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd6a3a5d47334aa6a79c66e514409e4e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd6a3a5d47334aa6a79c66e514409e4e"}}, "title": "The benefits, costs and feasibility of a low incidence COVID-19 strategy.", "authors": [{"family": "Czypionka", "given": "Thomas", "initials": "T"}, {"family": "Iftekhar", "given": "Emil N", "initials": "EN"}, {"family": "Prainsack", "given": "Barbara", "initials": "B"}, {"family": "Priesemann", "given": "Viola", "initials": "V"}, {"family": "Bauer", "given": "Simon", "initials": "S"}, {"family": "Calero Valdez", "given": "Andr\u00e9", "initials": "A"}, {"family": "Cuschieri", "given": "Sarah", "initials": "S"}, {"family": "Glaab", "given": "Enrico", "initials": "E"}, {"family": "Grill", "given": "Eva", "initials": "E"}, {"family": "Krutzinna", "given": "Jenny", "initials": "J"}, {"family": "Lionis", "given": "Christos", "initials": "C"}, {"family": "Machado", "given": "Helena", "initials": "H"}, {"family": "Martins", "given": "Carlos", "initials": "C"}, {"family": "Pavlakis", "given": "George N", "initials": "GN"}, {"family": "Perc", "given": "Matja\u017e", "initials": "M"}, {"family": "Petelos", "given": "Elena", "initials": "E"}, {"family": "Pickersgill", "given": "Martyn", "initials": "M"}, {"family": "Skupin", "given": "Alexander", "initials": "A"}, {"family": "Schernhammer", "given": "Eva", "initials": "E"}, {"family": "Szczurek", "given": "Ewa", "initials": "E"}, {"family": "Tsiodras", "given": "Sotirios", "initials": "S"}, {"family": "Willeit", "given": "Peter", "initials": "P"}, {"family": "Wilmes", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "13", "pages": "100294", "issn-l": null}, "abstract": "In the summer of 2021, European governments removed most NPIs after experiencing prolonged second and third waves of the COVID-19 pandemic. Most countries failed to achieve immunization rates high enough to avoid resurgence of the virus. Public health strategies for autumn and winter 2021 have ranged from countries aiming at low incidence by re-introducing NPIs to accepting high incidence levels. However, such high incidence strategies almost certainly lead to the very consequences that they seek to avoid: restrictions that harm people and economies. At high incidence, the important pandemic containment measure 'test-trace-isolate-support' becomes inefficient. At that point, the spread of SARS-CoV-2 and its numerous harmful consequences can likely only be controlled through restrictions. We argue that all European countries need to pursue a low incidence strategy in a coordinated manner. Such an endeavour can only be successful if it is built on open communication and trust.", "doi": "10.1016/j.lanepe.2021.100294", "pmid": "35005678", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00280-5"}, {"db": "pmc", "key": "PMC8720492"}], "notes": [], "created": "2022-01-13T21:09:51.362Z", "modified": "2022-01-13T21:09:51.378Z"}, {"entity": "publication", "iuid": "a36849b91d9f402f973b726bd0da8b38", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a36849b91d9f402f973b726bd0da8b38.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a36849b91d9f402f973b726bd0da8b38"}}, "title": "Risk of infection, hospitalisation, and death up to 9 months after a second dose of COVID-19 vaccine: a retrospective, total population cohort study in Sweden", "authors": [{"family": "Nordstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Ballin", "given": "Marcel", "initials": "M"}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal-article", "published": "2022-02-00", "journal": {"title": "Lancet", "issn": "0140-6736", "issn-l": null}, "abstract": null, "doi": "10.1016/s0140-6736(22)00089-7", "pmid": null, "labels": {"Category: Health": null, "Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-08T15:10:34.563Z", "modified": "2022-02-08T15:10:34.575Z"}, {"entity": "publication", "iuid": "0de9bcdefa794cf0a6b6b4c519a9c53e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0de9bcdefa794cf0a6b6b4c519a9c53e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0de9bcdefa794cf0a6b6b4c519a9c53e"}}, "title": "Quality of facility-based maternal and newborn care around the time of childbirth during the COVID-19 pandemic: online survey investigating maternal perspectives in 12 countries of the WHO European Region.", "authors": [{"family": "Lazzerini", "given": "Marzia", "initials": "M"}, {"family": "Covi", "given": "Benedetta", "initials": "B"}, {"family": "Mariani", "given": "Ilaria", "initials": "I"}, {"family": "Drglin", "given": "Zalka", "initials": "Z"}, {"family": "Arendt", "given": "Maryse", "initials": "M"}, {"family": "Nedberg", "given": "Ingvild Hersoug", "initials": "IH"}, {"family": "Elden", "given": "Helen", "initials": "H"}, {"family": "Costa", "given": "Raquel", "initials": "R"}, {"family": "Drandi\u0107", "given": "Daniela", "initials": "D"}, {"family": "Radeti\u0107", "given": "Jelena", "initials": "J"}, {"family": "Otelea", "given": "Marina Ruxandra", "initials": "MR"}, {"family": "Miani", "given": "C\u00e9line", "initials": "C"}, {"family": "Brigidi", "given": "Serena", "initials": "S"}, {"family": "Roz\u00e9e", "given": "Virginie", "initials": "V"}, {"family": "Ponikvar", "given": "Barbara Mihevc", "initials": "BM"}, {"family": "Tasch", "given": "Barbara", "initials": "B"}, {"family": "Kongslien", "given": "Sigrun", "initials": "S"}, {"family": "Linden", "given": "Karolina", "initials": "K"}, {"family": "Barata", "given": "Catarina", "initials": "C"}, {"family": "Kurbanovi\u0107", "given": "Magdalena", "initials": "M"}, {"family": "Ru\u017ei\u010di\u0107", "given": "Jovana", "initials": "J"}, {"family": "Batram-Zantvoort", "given": "Stephanie", "initials": "S"}, {"family": "Casta\u00f1eda", "given": "Lara Mart\u00edn", "initials": "LM"}, {"family": "Rochebrochard", "given": "Elise de La", "initials": "E"}, {"family": "Bohinec", "given": "Anja", "initials": "A"}, {"family": "Vik", "given": "Eline Skirnisdottir", "initials": "ES"}, {"family": "Zaigham", "given": "Mehreen", "initials": "M"}, {"family": "Santos", "given": "Teresa", "initials": "T"}, {"family": "Wandschneider", "given": "Lisa", "initials": "L"}, {"family": "Viver", "given": "Ana Canales", "initials": "AC"}, {"family": "\u0106erimagi\u0107", "given": "Amira", "initials": "A"}, {"family": "Sacks", "given": "Emma", "initials": "E"}, {"family": "Valente", "given": "Emanuelle Pessa", "initials": "EP"}, {"family": "IMAgiNE EURO study group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "13", "pages": "100268", "issn-l": null}, "abstract": "Multi-country studies assessing the quality of maternal and newborn care (QMNC) during the COVID-19 pandemic, as defined by WHO Standards, are lacking.\n\nWomen who gave birth in 12 countries of the WHO European Region from March 1, 2020 - March 15, 2021 answered an online questionnaire, including 40 WHO Standard-based Quality Measures.\n\n21,027 mothers were included in the analysis. Among those who experienced labour (N=18,063), 41\u00b78% (26\u00b71%- 63\u00b75%) experienced difficulties in accessing antenatal care, 62% (12\u00b76%-99\u00b70%) were not allowed a companion of choice, 31\u00b71% (16\u00b75%-56\u00b79%) received inadequate breastfeeding support, 34\u00b74% (5\u00b72%-64\u00b78%) reported that health workers were not always using protective personal equipment, and 31\u00b78% (17\u00b78%-53\u00b71%) rated the health workers' number as \"insufficient\". Episiotomy was performed in 20\u00b71% (6\u00b71%-66\u00b70%) of spontaneous vaginal births and fundal pressure applied in 41\u00b72% (11\u00b75% -100%) of instrumental vaginal births. In addition, 23\u00b79% women felt they were not treated with dignity (12\u00b78%-59\u00b78%), 12\u00b75% (7\u00b70%-23\u00b74%) suffered abuse, and 2\u00b74% (0\u00b71%-26\u00b72%) made informal payments. Most findings were significantly worse among women with prelabour caesarean birth (N=2,964). Multivariate analyses confirmed significant differences among countries, with Croatia, Romania, Serbia showing significant lower QMNC Indexes and Luxemburg showing a significantly higher QMNC Index than the total sample. Younger women and those with operative births also reported significantly lower QMNC Indexes.\n\nMothers reports revealed large inequities in QMNC across countries of the WHO European Region. Quality improvement initiatives to reduce these inequities and promote evidence-based, patient-centred respectful care for all mothers and newborns during the COVID-19 pandemic and beyond are urgently needed.\n\nThe study was financially supported by the Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy.\n\nClinicalTrials.gov Identifier: NCT04847336.", "doi": "10.1016/j.lanepe.2021.100268", "pmid": "34977838", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00254-4"}, {"db": "pmc", "key": "PMC8703114"}, {"db": "ClinicalTrials.gov", "key": "NCT04847336"}], "notes": [], "created": "2022-01-04T14:44:07.308Z", "modified": "2022-01-04T14:44:07.321Z"}, {"entity": "publication", "iuid": "c5f19e306adb4417b8cf7ec7c7f08643", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5f19e306adb4417b8cf7ec7c7f08643.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5f19e306adb4417b8cf7ec7c7f08643"}}, "title": "Mortality in hospitalized COVID-19 patients was associated with the COVID-19 admission rate during the first year of the pandemic in Sweden.", "authors": [{"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Wahlstr\u00f6m", "given": "Erik", "initials": "E"}, {"family": "Walther", "given": "Sten", "initials": "S"}, {"family": "Bennet-Bark", "given": "Anna M", "initials": "AM"}, {"family": "Heurgren", "given": "Mona", "initials": "M"}, {"family": "Lind\u00e9n", "given": "Thomas", "initials": "T"}, {"family": "Holm", "given": "Johanna", "initials": "J"}, {"family": "Hanberger", "given": "H\u00e5kan", "initials": "H"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "pages": "145-151", "volume": "54", "issue": "2", "issn-l": "2374-4235"}, "abstract": "Studies from the first pandemic wave found associations between COVID-19 hospital load and mortality. Here, we aimed to study if mortality of hospitalized COVID-19 patients was associated with the COVID-19 admission rate during a full year of the pandemic in Sweden.\n\nObservational review of all patients admitted to hospital with COVID-19 in Sweden between March 2020 and February 2021 (n = 42,017). Primary outcome was 60-day all-cause mortality related to number of COVID-19 hospital admissions per month/100,000 inhabitants. Poisson regression was used to estimate the relative risk for death by month of admission, adjusting for pre-existing factors.\n\nThe overall mortality was 17.4%. Excluding March 2020, mortality was clearly correlated to the number of COVID-19 admissions per month (coefficient of correlation \u03c1=.96; p<.0001). After adjustment for pre-existing factors, the correlation remained significant (\u03c1=.75, p=.02). Patients admitted in December (high admission rate and high mortality) had more comorbidities and longer hospital stays, and patients treated in intensive care units (ICU) had longer pre-ICU hospital stays and worse respiratory status on ICU admission than those admitted in July to September (low admission rate and low mortality).\n\nMortality in hospitalized COVID-19 patients was clearly associated with the COVID-19 admission rate. Admission of healthier patients between pandemic waves and delayed ICU care during wave peaks could contribute to this pattern. The study supports measures to flatten-the-curve to reduce the number of COVID-19 patients admitted to hospital.", "doi": "10.1080/23744235.2021.1983643", "pmid": "34612774", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:27:15.805Z", "modified": "2023-01-13T13:34:39.945Z"}, {"entity": "publication", "iuid": "c37b19480dee4ac5929dad2316314ed8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c37b19480dee4ac5929dad2316314ed8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c37b19480dee4ac5929dad2316314ed8"}}, "title": "Mortality in Norway and Sweden during the COVID-19 pandemic.", "authors": [{"family": "Juul", "given": "Frederik E", "initials": "FE", "orcid": "0000-0003-3317-6988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4523958ae7f845afa749e7925890d292.json"}}, {"family": "Jodal", "given": "Henriette C", "initials": "HC", "orcid": "0000-0001-6957-9469", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6700190f6094980bc6542652f2aa833.json"}}, {"family": "Barua", "given": "Ishita", "initials": "I"}, {"family": "Refsum", "given": "Erle", "initials": "E"}, {"family": "Olsvik", "given": "\u00d8rjan", "initials": "\u00d8"}, {"family": "Helsingen", "given": "Lise M", "initials": "LM"}, {"family": "L\u00f8berg", "given": "Magnus", "initials": "M"}, {"family": "Bretthauer", "given": "Michael", "initials": "M"}, {"family": "Kalager", "given": "Mette", "initials": "M"}, {"family": "Emilsson", "given": "Louise", "initials": "L"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "38-45", "volume": "50", "issue": "1", "issn-l": "1403-4948"}, "abstract": "Background: Norway and Sweden are similar countries in terms of socioeconomics and health care. Norway implemented extensive COVID-19 measures, such as school closures and lockdowns, whereas Sweden did not. Aims: To compare mortality in Norway and Sweden, two similar countries with very different mitigation measures against COVID-19. Methods: Using real-world data from national registries, we compared all-cause and COVID-19-related mortality rates with 95% confidence intervals (CI) per 100,000 person-weeks and mortality rate ratios (MRR) comparing the five preceding years (2015-2019) with the pandemic year (2020) in Norway and Sweden. Results: In Norway, all-cause mortality was stable from 2015 to 2019 (mortality rate 14.6-15.1 per 100,000 person-weeks; mean mortality rate 14.9) and was lower in 2020 than from 2015 to 2019 (mortality rate 14.4; MRR 0.97; 95% CI 0.96-0.98). In Sweden, all-cause mortality was stable from 2015 to 2018 (mortality rate 17.0-17.8; mean mortality rate 17.1) and similar to that in 2020 (mortality rate 17.6), but lower in 2019 (mortality rate 16.2). Compared with the years 2015-2019, all-cause mortality in the pandemic year was 3% higher due to the lower rate in 2019 (MRR 1.03; 95% CI 1.02-1.04). Excess mortality was confined to people aged \u2a7e70 years in Sweden compared with previous years. The COVID-19-associated mortality rates per 100,000 person-weeks during the first wave of the pandemic were 0.3 in Norway and 2.9 in Sweden. Conclusions: All-cause mortality in 2020 decreased in Norway and increased in Sweden compared with previous years. The observed excess deaths in Sweden during the pandemic may, in part, be explained by mortality displacement due to the low all-cause mortality in the previous year.", "doi": "10.1177/14034948211047137", "pmid": "34609261", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8807990"}], "notes": [], "created": "2021-10-10T15:29:25.585Z", "modified": "2023-07-13T11:29:07.186Z"}, {"entity": "publication", "iuid": "952cfb24d67248238d32e5d03d5a3116", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/952cfb24d67248238d32e5d03d5a3116.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/952cfb24d67248238d32e5d03d5a3116"}}, "title": "Mining user reviews of COVID contact-tracing apps: An exploratory analysis of nine European apps.", "authors": [{"family": "Garousi", "given": "Vahid", "initials": "V"}, {"family": "Cutting", "given": "David", "initials": "D"}, {"family": "Felderer", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "J Syst Softw", "issn": "0164-1212", "volume": "184", "pages": "111136", "issn-l": null}, "abstract": "More than 78 countries have developed COVID contact-tracing apps to limit the spread of coronavirus. However, many experts and scientists cast doubt on the effectiveness of those apps. For each app, a large number of reviews have been entered by end-users in app stores.\n\nOur goal is to gain insights into the user reviews of those apps, and to find out the main problems that users have reported. Our focus is to assess the \"software in society\" aspects of the apps, based on user reviews.\n\nWe selected nine European national apps for our analysis and used a commercial app-review analytics tool to extract and mine the user reviews. For all the apps combined, our dataset includes 39,425 user reviews.\n\nResults show that users are generally dissatisfied with the nine apps under study, except the Scottish (\"Protect Scotland\") app. Some of the major issues that users have complained about are high battery drainage and doubts on whether apps are really working.\n\nOur results show that more work is needed by the stakeholders behind the apps (e.g., app developers, decision-makers, public health experts) to improve the public adoption, software quality and public perception of these apps.", "doi": "10.1016/j.jss.2021.111136", "pmid": "34751198", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0164-1212(21)00233-8"}, {"db": "pmc", "key": "PMC8566091"}], "notes": [], "created": "2021-11-26T15:24:59.824Z", "modified": "2021-11-26T15:24:59.858Z"}, {"entity": "publication", "iuid": "112f72343b48421da285c080bad59e9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/112f72343b48421da285c080bad59e9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/112f72343b48421da285c080bad59e9c"}}, "title": "Intensive care-treated COVID-19 patients' perception of their illness and remaining symptoms.", "authors": [{"family": "Wallin", "given": "Ewa", "initials": "E", "orcid": "0000-0003-2492-8666", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9dce246ac6b4c178c7556613294dd2b.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Rubertsson", "given": "Sten", "initials": "S"}, {"family": "Larsson", "given": "Ing-Marie", "initials": "I"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": "66", "issue": "2", "pages": "240-247"}, "abstract": "The remaining symptoms in patients with coronavirus disease 2019 (COVID-19) treated in intensive care unit are limited described. Therefore, we assessed patient's perception of their COVID-19 disease, stay in intensive care, and remaining symptoms three to six months after intensive care.\r\n\r\nProspective cohort study was performed in one intensive care unit of a university hospital in Sweden during the first wave. A questionnaire with open-ended questions and closed-ended questions was used. Data were analyzed using qualitative and quantitative content analysis and descriptive statistics.\r\n\r\nOut of 123 patients treated for COVID-19, 64 answered the questionnaire 3-6 months after discharge from intensive care. Memories from illness and hospital stay revealed in three categories; awareness of the illness, losing anchor to reality and being cared for in a dynamic environment. Information was perceived as spare by 48% and they wanted the information to be more personal. The diary was perceived as personal and was received by 33% patients. The relationship with family was affected among 39% and 13% of the patients indicated that they had not resumed their daily life. A large amount, 84%, indicated that they had remaining symptoms from COVID-19. The dominated symptoms were impaired strength and energy both physically and mentally.\r\n\r\nPatients reported a variety of physical and mental symptoms, and revealed memories from the ICU, and specific awareness of other patients' health. It illustrates the need for screening patients for remaining symptoms after COVID-19 disease and ICU care and may affect resuming patients' daily life.", "doi": "10.1111/aas.13992", "pmid": "34704256", "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pmc", "key": "PMC8653095"}], "notes": [], "created": "2021-11-01T19:42:20.654Z", "modified": "2022-02-08T19:16:01.129Z"}, {"entity": "publication", "iuid": "cfacc9763ebf480ab738d5d9b4caa532", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfacc9763ebf480ab738d5d9b4caa532.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfacc9763ebf480ab738d5d9b4caa532"}}, "title": "How children in Sweden accessed and perceived information during the first phase of the Covid-19 pandemic.", "authors": [{"family": "Rydstr\u00f6m", "given": "Lise-Lott", "initials": "LL", "orcid": "0000-0002-1007-1959", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad5251de283d4f73b0c2ac600a34a19a.json"}}, {"family": "\u00c5ngstr\u00f6m-Br\u00e4nnstr\u00f6m", "given": "Charlotte", "initials": "C"}, {"family": "Blake", "given": "Lucy", "initials": "L"}, {"family": "Brayl", "given": "Lucy", "initials": "L"}, {"family": "Carter", "given": "Bernie", "initials": "B"}, {"family": "Forsner", "given": "Maria", "initials": "M"}, {"family": "Matsson", "given": "Janet", "initials": "J"}, {"family": "Nilsson", "given": "Stefan", "initials": "S"}, {"family": "Jenholt Nolbris", "given": "Margaretha", "initials": "M", "orcid": "0000-0002-6911-1484", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f53d9c5dc5ff46149ef63e16dfa6d7a1.json"}}, {"family": "Kirton", "given": "Jennifer", "initials": "J"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "Protheroe", "given": "Joanne", "initials": "J"}, {"family": "Rullander", "given": "Anna-Clara", "initials": "AC"}, {"family": "Saron", "given": "Holly", "initials": "H"}, {"family": "Lindholm Olinder", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "144-151", "volume": "50", "issue": "1", "issn-l": "1403-4948"}, "abstract": "To describe how children in Sweden accessed and perceived information about SARS-CoV2 and Covid-19 during the first phase of the outbreak.\n\nThis study is a substudy of an international cross-sectional online mixed methods survey examining elements of children's health literacy in relation to Covid-19. The survey included multiple-choice questions, open-ended questions and drawings and collected information from 50 Swedish children (7-12 years). Data were analysed concurrently on a descriptive level using statistics and content analysis. Quantitative and qualitative data, including the drawings, were considered equally important and resulted in six categories, illuminating how children accessed and perceived information about the pandemic.\n\nThe survey showed that children accessed information mainly from school but also from TV. They preferred information from reliable sources. Children reported the information they accessed as easy to understand and it prompted them to ask new questions. They reported they knew a lot about the pandemic, for example, the potential danger to themselves and others and how to act to protect themselves and others. They perceived the pandemic as an intrusion on their lives.\n\nThis study indicates that Swedish children between 7 and 12 years old were well informed about SARS-CoV2 and Covid-19 during the first phase of the pandemic. School was shown to be an important source of information. The children could explain how to act to protect themselves and others from becoming infected by the virus.", "doi": "10.1177/14034948211051884", "pmid": "34736348", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8807992"}], "notes": [], "created": "2021-11-08T09:16:39.380Z", "modified": "2023-01-13T13:51:41.582Z"}, {"entity": "publication", "iuid": "60ee8787609f4c53af2c09abcf3a14a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60ee8787609f4c53af2c09abcf3a14a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60ee8787609f4c53af2c09abcf3a14a0"}}, "title": "Effects of the COVID-19 pandemic on the mental health of seafarers: A comparison using matched samples.", "authors": [{"family": "Pauksztat", "given": "Birgit", "initials": "B"}, {"family": "Andrei", "given": "Daniela M", "initials": "DM"}, {"family": "Grech", "given": "Michelle R", "initials": "MR"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Saf Sci", "issn": "0925-7535", "volume": "146", "pages": "105542", "issn-l": null}, "abstract": "The COVID-19 pandemic and the measures implemented to curb its transmission have altered workplaces and challenged occupational health and safety in unprecedented ways, with high levels of mental distress reported across several industries. In the maritime industry, occupational health and safety risks, including psychosocial risks, were a concern already before the COVID-19 pandemic. However, knowledge about the prevalence of mental health problems and the factors associated with them is still limited. The purpose of this study was to investigate the impact of the COVID-19 pandemic as well as the effects of respondent and work-related characteristics on seafarers' self-reported symptoms of depression and anxiety. Data came from two cross-sectional convenience samples of seafarers on international commercial vessels, surveyed before (Npre-pandemic = 793) and during the pandemic (Npandemic = 504). Matching the two samples on respondent and work-related characteristics using propensity scores, we found that the pandemic contributed to significantly higher levels of depression and anxiety. Further analyses showed that seafarers with longer work periods, those who had been on board longer than expected, and those working on vessels registered with \"Flags of Convenience\" reported significantly higher levels of both depression and anxiety during the pandemic, but not prior to the pandemic. Taken together, these findings suggest that the impact of the COVID-19 pandemic led to a deterioration of working conditions and increased mental health risks for seafarers. Practical implications for safe-guarding occupational health and safety during this and future crises are discussed.", "doi": "10.1016/j.ssci.2021.105542", "pmid": "34744311", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0925-7535(21)00385-4"}, {"db": "pmc", "key": "PMC8556536"}], "notes": [], "created": "2021-11-26T15:36:01.988Z", "modified": "2021-11-26T15:36:02.000Z"}, {"entity": "publication", "iuid": "bbd1f4a00548411baa09980def7774e3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bbd1f4a00548411baa09980def7774e3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bbd1f4a00548411baa09980def7774e3"}}, "title": "Digital communities of practice: one step towards decolonising global health partnerships.", "authors": [{"family": "Sant Fruchtman", "given": "Carmen", "initials": "C", "orcid": "0000-0002-5276-3515", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a71c19d528084816a975a3df84a7e2bc.json"}}, {"family": "Bilal Khalid", "given": "Muhammad", "initials": "M", "orcid": "0000-0003-3986-7093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5037eaca65284f5cad172d462853272d.json"}}, {"family": "Keakabetse", "given": "Tshiamo", "initials": "T", "orcid": "0000-0003-0725-0961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2309f59fae34a388d346452b97f78e5.json"}}, {"family": "Bonito", "given": "Antonio", "initials": "A"}, {"family": "Saulnier", "given": "Dell D", "initials": "DD", "orcid": "0000-0001-7761-0737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d3fc961101845b1ae844339af7495e4.json"}}, {"family": "Mupara", "given": "Lucia Mungapeyi", "initials": "LM", "orcid": "0000-0003-3497-624X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea507bc1ee1248ceb82868ff1d30fa81.json"}}, {"family": "Iqbal", "given": "Shahid", "initials": "S", "orcid": "0000-0002-9211-1212", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b0e092055ca4eb395503bb02161ef31.json"}}, {"family": "de Almeida", "given": "Afonso", "initials": "A"}, {"family": "da Silva", "given": "Hendriketa", "initials": "H"}, {"family": "de Jesus", "given": "Diamantino", "initials": "D"}, {"family": "Prytherch", "given": "Helen", "initials": "H"}, {"family": "Mokalake", "given": "Ellen", "initials": "E"}, {"family": "Cobos Mu\u00f1oz", "given": "Daniel", "initials": "D", "orcid": "0000-0002-5920-1304", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89b7c57ce7304d659ec7a077a0a841dc.json"}}, {"family": "Zafar", "given": "Shamsa", "initials": "S", "orcid": "0000-0003-4397-5505", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/880e602fe5c64b8182e075f1f17caa8c.json"}}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "7", "issue": "2", "issn-l": "2059-7908"}, "abstract": null, "doi": "10.1136/bmjgh-2021-008174", "pmid": "35110274", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-008174"}], "notes": [], "created": "2022-02-06T16:49:54.389Z", "modified": "2022-02-06T16:49:54.650Z"}, {"entity": "publication", "iuid": "a3ed4c5b77514da0a2a847afe8a47040", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3ed4c5b77514da0a2a847afe8a47040.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3ed4c5b77514da0a2a847afe8a47040"}}, "title": "Dataset: COVID-19 epidemic policy and events timeline (Sweden).", "authors": [{"family": "Olofsson", "given": "Tobias", "initials": "T"}, {"family": "Vilhelmsson", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Data Brief", "issn": "2352-3409", "volume": "40", "pages": "107698", "issn-l": null}, "abstract": "The Swedish approach to managing the 2020-2021 COVID-19 pandemic has received significant attention in international scholarly work and press. For this dataset, we have reviewed governmental and media archives to build a detailed timeline that chronicles significant policies, interventions, and events in the Swedish management of COVID-19. The dataset contains summary descriptions of what took place, when it happened, and who the principal actors involved were. Links to primary sources are provided for each entry. Because of the level of detail and saturation, the dataset offers a detailed account of Swedish pandemic governance and will benefit anyone working on Swedish pandemic management or doing comparative work between Sweden and other jurisdictions.", "doi": "10.1016/j.dib.2021.107698", "pmid": "34926743", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2352-3409(21)00973-2"}, {"db": "pmc", "key": "PMC8667349"}, {"db": "URL", "key": "https://doi.org/10.5281/zenodo.5718433", "description": "https://doi.org/10.5281/zenodo.5718433"}], "notes": [], "created": "2022-01-03T15:24:42.157Z", "modified": "2022-01-03T15:25:34.875Z"}, {"entity": "publication", "iuid": "47860632a9a641bc8cfc1e7a85fb5e30", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47860632a9a641bc8cfc1e7a85fb5e30.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47860632a9a641bc8cfc1e7a85fb5e30"}}, "title": "Compliance with recommendations limiting COVID-19 contagion among university students in Sweden: associations with self-reported symptoms, mental health and academic self-efficacy.", "authors": [{"family": "Berman", "given": "Anne H", "initials": "AH", "orcid": "0000-0002-7709-0230", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c6d87ccfe79452d920ffbe797143f38.json"}}, {"family": "Bendtsen", "given": "Marcus", "initials": "M"}, {"family": "Molander", "given": "Olof", "initials": "O"}, {"family": "Lindfors", "given": "Petra", "initials": "P"}, {"family": "Lindner", "given": "Philip", "initials": "P"}, {"family": "Granlund", "given": "Lilian", "initials": "L"}, {"family": "Topooco", "given": "Naira", "initials": "N"}, {"family": "Engstr\u00f6m", "given": "Karin", "initials": "K"}, {"family": "Andersson", "given": "Claes", "initials": "C"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": "50", "issue": "1", "pages": "70-84"}, "abstract": "The COVID-19 containment strategy in Sweden uses public health recommendations relying on personal responsibility for compliance. Universities were one of few public institutions subject to strict closure, meaning that students had to adapt overnight to online teaching. This study investigates the prevalence of self-reported recommendation compliance and associations with self-reported symptoms of contagion, self-experienced effects on mental health and academic self-efficacy among university students in Sweden in May-June 2020.\n\nThis was a cross-sectional 23 question online survey in which data were analysed by multinomial regression, taking a Bayesian analysis approach complemented by null hypothesis testing.\n\nA total of 4495 students consented to respond. Recommendation compliance ranged between 70% and 96%. Women and older students reported higher compliance than did men and younger students. Mild to moderate COVID-19 symptoms were reported by 30%, severe symptoms by fewer than 2%; 15% reported being uncertain and half of the participants reported no symptoms. Mental health effects were reported by over 80%, and changes in academic self-efficacy were reported by over 85%; in both these areas negative effects predominated. Self-reported symptoms and uncertainty about contagion were associated with non-compliance, negative mental health effects, and impaired academic self-efficacy.\n\nStudents generally followed public health recommendations during strict closure of universities, but many reported considerable negative consequences related to mental health and academic self-efficacy. Digital interventions should be developed and evaluated to boost coping skills, build resilience and alleviate student suffering during the pandemic and future similar crises.", "doi": "10.1177/14034948211027824", "pmid": "34213359", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8808007"}], "notes": [], "created": "2021-07-05T15:00:03.045Z", "modified": "2023-06-19T14:25:17.882Z"}, {"entity": "publication", "iuid": "c1f1248fa5f24349b1f8e426ec55841b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1f1248fa5f24349b1f8e426ec55841b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1f1248fa5f24349b1f8e426ec55841b"}}, "title": "Co-circulation of SARS-CoV-2 Alpha and Gamma variants in Italy, February and March 2021.", "authors": [{"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Trentini", "given": "Filippo", "initials": "F"}, {"family": "Guzzetta", "given": "Giorgio", "initials": "G"}, {"family": "Marziano", "given": "Valentina", "initials": "V"}, {"family": "Mammone", "given": "Alessia", "initials": "A"}, {"family": "Sane Schepisi", "given": "Monica", "initials": "M"}, {"family": "Poletti", "given": "Piero", "initials": "P"}, {"family": "Molina Gran\u00e9", "given": "Carla", "initials": "C"}, {"family": "Manica", "given": "Mattia", "initials": "M"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Ajelli", "given": "Marco", "initials": "M"}, {"family": "Rezza", "given": "Giovanni", "initials": "G"}, {"family": "Brusaferro", "given": "Silvio", "initials": "S"}, {"family": "Merler", "given": "Stefano", "initials": "S"}, {"family": "COVID-19 National Microbiology Surveillance Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "27", "issue": "5", "issn-l": null}, "abstract": "BackgroundSeveral SARS-CoV-2 variants of concern (VOC) have emerged through 2020 and 2021. There is need for tools to estimate the relative transmissibility of emerging variants of SARS-CoV-2 with respect to circulating strains.AimWe aimed to assess the prevalence of co-circulating VOC in Italy and estimate their relative transmissibility.MethodsWe conducted two genomic surveillance surveys on 18 February and 18 March 2021 across the whole Italian territory covering 3,243 clinical samples and developed a mathematical model that describes the dynamics of co-circulating strains.ResultsThe Alpha variant was already dominant on 18 February in a majority of regions/autonomous provinces (national prevalence: 54%) and almost completely replaced historical lineages by 18 March (dominant across Italy, national prevalence: 86%). We found a substantial proportion of the Gamma variant on 18 February, almost exclusively in central Italy (prevalence: 19%), which remained similar on 18 March. Nationally, the mean relative transmissibility of Alpha ranged at 1.55-1.57 times the level of historical lineages (95% CrI: 1.45-1.66). The relative transmissibility of Gamma varied according to the assumed degree of cross-protection from infection with other lineages and ranged from 1.12 (95% CrI: 1.03-1.23) with complete immune evasion to 1.39 (95% CrI: 1.26-1.56) for complete cross-protection.ConclusionWe assessed the relative advantage of competing viral strains, using a mathematical model assuming different degrees of cross-protection. We found substantial co-circulation of Alpha and Gamma in Italy. Gamma was not able to outcompete Alpha, probably because of its lower transmissibility.", "doi": "10.2807/1560-7917.ES.2022.27.5.2100429", "pmid": "35115077", "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-06T16:47:07.921Z", "modified": "2022-02-06T16:47:07.934Z"}, {"entity": "publication", "iuid": "657c84fe12664bbcb560de7d0549c6b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/657c84fe12664bbcb560de7d0549c6b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/657c84fe12664bbcb560de7d0549c6b2"}}, "title": "Clinical phenotypes and outcomes of SARS-CoV-2, influenza, RSV and seven other respiratory viruses: a retrospective study using complete hospital data.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P", "orcid": "0000-0003-3153-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd6af5accfc84ff9a81983a5ab6683aa.json"}}, {"family": "Karlsson Valik", "given": "John", "initials": "J"}, {"family": "van der Werff", "given": "Suzanne", "initials": "S"}, {"family": "Tanushi", "given": "Hideyuki", "initials": "H"}, {"family": "Requena Mendez", "given": "Ana", "initials": "A"}, {"family": "Granath", "given": "Fredrik", "initials": "F"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}, {"family": "Dyrdak", "given": "Robert", "initials": "R"}, {"family": "Hertting", "given": "Olof", "initials": "O"}, {"family": "F\u00e4rnert", "given": "Anna", "initials": "A"}, {"family": "Ternhag", "given": "Anders", "initials": "A"}, {"family": "Naucler", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Thorax", "issn": "1468-3296", "volume": "77", "issue": "2", "pages": "154-163", "issn-l": null}, "abstract": "An understanding of differences in clinical phenotypes and outcomes COVID-19 compared with other respiratory viral infections is important to optimise the management of patients and plan healthcare. Herein we sought to investigate such differences in patients positive for SARS-CoV-2 compared with influenza, respiratory syncytial virus (RSV) and other respiratory viruses.\n\nWe performed a retrospective cohort study of hospitalised adults and children (\u226415 years) who tested positive for SARS-CoV-2, influenza virus A/B, RSV, rhinovirus, enterovirus, parainfluenza viruses, metapneumovirus, seasonal coronaviruses, adenovirus or bocavirus in a respiratory sample at admission between 2011 and 2020.\n\nA total of 6321 adult (1721 SARS-CoV-2) and 6379 paediatric (101 SARS-CoV-2) healthcare episodes were included in the study. In adults, SARS-CoV-2 positivity was independently associated with younger age, male sex, overweight/obesity, diabetes and hypertension, tachypnoea as well as better haemodynamic measurements, white cell count, platelet count and creatinine values. Furthermore, SARS-CoV-2 was associated with higher 30-day mortality as compared with influenza (adjusted HR (aHR) 4.43, 95% CI 3.51 to 5.59), RSV (aHR 3.81, 95% CI 2.72 to 5.34) and other respiratory viruses (aHR 3.46, 95% CI 2.61 to 4.60), as well as higher 90-day mortality, ICU admission, ICU mortality and pulmonary embolism in adults. In children, patients with SARS-CoV-2 were older and had lower prevalence of chronic cardiac and respiratory diseases compared with other viruses.\n\nSARS-CoV-2 is associated with more severe outcomes compared with other respiratory viruses, and although associated with specific patient and clinical characteristics at admission, a substantial overlap precludes discrimination based on these characteristics.", "doi": "10.1136/thoraxjnl-2021-216949", "pmid": "34226206", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8260304"}, {"db": "pii", "key": "thoraxjnl-2021-216949"}], "notes": [], "created": "2021-08-06T08:46:41.794Z", "modified": "2023-06-19T14:44:08.102Z"}, {"entity": "publication", "iuid": "c7700ea76af04c2587f6db8b1e4cb614", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7700ea76af04c2587f6db8b1e4cb614.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7700ea76af04c2587f6db8b1e4cb614"}}, "title": "Can field botany be effectively taught as a distance course? Experiences and reflections from the COVID-19 pandemic.", "authors": [{"family": "Auffret", "given": "Alistair G", "initials": "AG"}, {"family": "Ekholm", "given": "Adam", "initials": "A"}, {"family": "H\u00e4m\u00e4l\u00e4inen", "given": "Aino", "initials": "A"}, {"family": "Jonsell", "given": "Mats", "initials": "M"}, {"family": "Lehto", "given": "Carl", "initials": "C"}, {"family": "Nordkvist", "given": "Michelle", "initials": "M"}, {"family": "\u00d6ckinger", "given": "Erik", "initials": "E"}, {"family": "Torstensson", "given": "Peter", "initials": "P"}, {"family": "Viketoft", "given": "Maria", "initials": "M"}, {"family": "Thor", "given": "G\u00f6ran", "initials": "G"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "AoB Plants", "issn": "2041-2851", "volume": "14", "issue": "1", "pages": "plab079", "issn-l": null}, "abstract": "The COVID-19 pandemic that started in 2020 forced a rapid change in university teaching, with large numbers of courses switching to distance learning with very little time for preparation. Courses involving many practical elements and field excursions required particular care if students were to fulfil planned learning outcomes. Here, we present our experiences in teaching field botany in 2020 and 2021. Using a range of methods and tools to introduce students to the subject, promote self-learning and reflection and give rapid and regular feedback, we were able to produce a course that allowed students to achieve the intended learning outcomes and that obtained similarly positive student evaluations to previous years. The course and its outcomes were further improved in 2021. We describe how we structured field botany as a distance course in order that we could give the best possible learning experience for the students. Finally, we reflect on how digital tools can aid teaching such subjects in the future, in a world where public knowledge of natural history is declining.", "doi": "10.1093/aobpla/plab079", "pmid": "35035870", "labels": {"Topics: Register-based research": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "plab079"}, {"db": "pmc", "key": "PMC8757578"}], "notes": [], "created": "2022-01-27T07:40:01.555Z", "modified": "2022-01-27T07:40:01.591Z"}, {"entity": "publication", "iuid": "dc69051024a24f44a2ef332f63c87a44", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dc69051024a24f44a2ef332f63c87a44.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dc69051024a24f44a2ef332f63c87a44"}}, "title": "COVID-19 among young adults in Sweden: self-reported long-term symptoms and associated factors.", "authors": [{"family": "Ekstr\u00f6m", "given": "Sandra", "initials": "S", "orcid": "0000-0002-2060-8190", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d63bc101e23740dcae35eefe950ca767.json"}}, {"family": "Andersson", "given": "Niklas", "initials": "N"}, {"family": "L\u00f6vquist", "given": "Alexandra", "initials": "A"}, {"family": "Lauber", "given": "Andr\u00e9", "initials": "A"}, {"family": "Georgelis", "given": "Antonios", "initials": "A"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E", "orcid": "0000-0002-8248-0663", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58e96082947e4752a23f322e42754097.json"}}, {"family": "Bergstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "85-93", "volume": "50", "issue": "1", "issn-l": "1403-4948"}, "abstract": "The main aim of the study was to describe self-reported symptoms of COVID-19 and examine if long-term symptoms are associated with lifestyle factors or common chronic diseases among Swedish young adults. A secondary aim was to compare the prevalence of smoking and snuff use before and during the COVID-19 pandemic.\n\nThe study population includes 1644 participants aged 23-26 years from the Swedish population-based birth cohort BAMSE. From August to November 2020, the participants answered a web questionnaire on COVID-19 symptoms, lifestyle and health. Information on tobacco use was compared against the previous study follow-up in 2016-2019.\n\nThe prevalence of suspected COVID-19 symptoms was 45.3% (n=742), and 80 of these (10.8%) reported long-term symptoms (\u2a7e4 weeks). There was no significant difference in sociodemographic or lifestyle factors in relation to the duration of suspected COVID-19 symptoms. Rhinitis, migraine and lower self-rated health before the pandemic was more common among participants with long-term symptoms. In addition, there was a tendency for higher prevalences of asthma, chronic bronchitis and depression in this group. The prevalence of smoking decreased from 18.9% before the pandemic to 14.7% during the pandemic, while snuff use increased from 12.7% to 22.4% (P<0.001).\n\nAlmost half of Swedish young adults have had symptoms of suspected COVID-19 from February up to August 2020. Among these, one out of 10 have had long-term symptoms for at least 4 weeks. Long-term symptoms of suspected COVID-19 were associated with several common chronic conditions. Smoking may have decreased during the pandemic, while snuff use may have increased.", "doi": "10.1177/14034948211025425", "pmid": "34148461", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8808012"}], "notes": [], "created": "2021-06-28T18:26:14.483Z", "modified": "2023-01-13T13:27:23.137Z"}, {"entity": "publication", "iuid": "5ece2c02daa34aa399d877bf9a35a88e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5ece2c02daa34aa399d877bf9a35a88e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5ece2c02daa34aa399d877bf9a35a88e"}}, "title": "A systems analysis of the COVID-19 pandemic response in the United Kingdom - Part 1 - The overall context.", "authors": [{"family": "Slater", "given": "David", "initials": "D"}, {"family": "Hollnagel", "given": "Erik", "initials": "E"}, {"family": "MacKinnon", "given": "Ralph", "initials": "R"}, {"family": "Sujan", "given": "Mark", "initials": "M"}, {"family": "Carson-Stevens", "given": "Andrew", "initials": "A"}, {"family": "Ross", "given": "Alistair", "initials": "A"}, {"family": "Bowie", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Saf Sci", "issn": "0925-7535", "volume": "146", "pages": "105525", "issn-l": null}, "abstract": "The most common reaction to suggesting that we could learn valuable lessons from the way the current pandemic has been/ is being handled, is to discourage the attempt; as it is suggested that it can all be done more accurately and authoritatively after the inevitable Public Inquiry (Slater, 2019). On the other hand, a more constructive approach, is to capture and understand the work that was actually done.This would include normal activities, as well as positive adaptations to challenges and failures that may have occurred. Such an approach aimed at improving what worked, rather than blaming people for what went wrong, has the potential to contribute more successfully to controlling the consequences of the current crisis. Such an approach should thus be aimed at detecting and feeding back lessons from emerging and probably unexpected behaviours and helping to design the system to adapt better to counter the effects. The science and discipline of Human Factors (HF) promotes system resilience. This can be defined as an organisation's ability to adjust its functioning before, during or after significant disturbances (such as a pandemic), enabling adaptation and operation under both anticipated and unanticipated circumstances. A \"functional\" approach methodology enables the identification of where the system and its various interdependent functions (an activity or set of activities that are required to give a certain output), could be improved and strengthened; if not immediately, at least for the future. Along these lines, suggestions for adding key resilience functions are additionally identified and outlined. The application and insights gained from this functional approach to the 2015 MERS-Cov pandemic in South Korea has been seen as contributing substantially to the effective response to the current crisis in that country (Min, submitted for publication). In this paper, we present an overarching framework for a series of projects that are planned to carry out focussed systems-based analysis to generate learning from key aspects of the COVID-19 pandemic response in the United Kingdom.", "doi": "10.1016/j.ssci.2021.105525", "pmid": "34658531", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0925-7535(21)00368-4"}, {"db": "pmc", "key": "PMC8501230"}], "notes": [], "created": "2021-10-21T05:01:44.575Z", "modified": "2021-10-21T05:01:44.589Z"}, {"entity": "publication", "iuid": "b145abeb119c458e98cbe2e264a72941", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b145abeb119c458e98cbe2e264a72941.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b145abeb119c458e98cbe2e264a72941"}}, "title": "Pain Burden in Post-COVID-19 Syndrome following Mild COVID-19 Infection.", "authors": [{"family": "Bileviciute-Ljungar", "given": "Indre", "initials": "I"}, {"family": "Norrefalk", "given": "Jan-Rickard", "initials": "JR", "orcid": "0000-0002-7070-3268", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24718b50907344ec9053bfc5d8495f19.json"}}, {"family": "Borg", "given": "Kristian", "initials": "K"}], "type": "journal article", "published": "2022-01-31", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "11", "issue": "3", "pages": "771"}, "abstract": "The global pandemic of SARS-CoV-2 has affected several hundred million people, and many infected people have suffered from a milder initial infection but have never fully recovered. This observational study investigates the pain burden in sufferers of post-COVID-19 syndrome after a milder initial infection. One hundred post-COVID-19 patients filled out questionnaires regarding sociodemographic data, previous comorbidities, present pharmacological treatment, pain intensity and pain localisation. Health-related quality of life, fatigue, emotional status, and insomnia were measured by validated questionnaires. Multiple post-COVID-19 symptoms, including post-exertional malaise, were evaluated by a symptom questionnaire. Among the 100 participants (mean age 44.5 years), 82% were women, 61% had higher education, and 56% were working full or part time. Nine participants reported previous pain or inflammatory conditions. Among the most painful sites were the head/face, chest, lower extremities, and migrating sites. Generalised pain was self-reported by 75 participants and was estimated in 50 participants. Diagnosis of fibromyalgia according to the 2016 criteria was suspected in 40 participants. Subgroup analyses indicated that comorbidities might play a role in the development of pain. In conclusion, a major part of sufferers from post-COVID-19 syndrome develop pain, and in addition to its many disabling symptoms, there is an urgent need for pain management in post-COVID-19 syndrome.", "doi": "10.3390/jcm11030771", "pmid": "35160223", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC8836662"}, {"db": "pii", "key": "jcm11030771"}], "notes": [], "created": "2022-02-17T06:10:30.240Z", "modified": "2023-06-19T15:16:34.767Z"}, {"entity": "publication", "iuid": "453141f6204344c5a19dc358dd5264bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/453141f6204344c5a19dc358dd5264bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/453141f6204344c5a19dc358dd5264bf"}}, "title": "Multi-professional Neurorehabilitation after Covid-19 Infection Should Include Assessment of Visual Function: Visual function after Covid-19 infection.", "authors": [{"family": "Johansson", "given": "Jan", "initials": "J"}, {"family": "Levi", "given": "Richard", "initials": "R"}, {"family": "Jakobsson", "given": "Maria", "initials": "M"}, {"family": "Gunnarsson", "given": "Stina", "initials": "S"}, {"family": "Samuelsson", "given": "Kersti", "initials": "K"}], "type": "journal article", "published": "2022-01-31", "journal": {"title": "Arch Rehabil Res Clin Transl", "issn": "2590-1095", "pages": "100184", "issn-l": null}, "abstract": "To report vision-related symptoms and neuro-visual clinical signs in patients approximately 4 months after discharge from hospitalization after Covid-19 infection. To report on co-existing functional and activity limitations.\n\nThe study is part of an ambi-directional population-based cohort study.\n\nAn outpatient setting in a hospital environment.\n\nPatients from a population-based cohort study including all laboratory-confirmed cases of Covid-19 admitted to hospital during a 3-month period in a health care region in Sweden. Among patients who, based on a standardized telephone interview, were identified as having persisting rehabilitation needs 4 months after discharge (n=185), several (n=57) reported vision-related symptoms. All 57 patients were invited to a neuro-visual examination. Six patients declined, six were unavailable and three did not fulfil the inclusion criteria. Thus 42 patients were included in the analysis.\n\nNot applicable.\n\nVision-related symptoms, neuro-visual function, and co-existing impairments affecting activities of daily life and participation.\n\nThirty-one percent of patients with rehabilitation needs after Covid-19 reported vision-related symptoms. Reading-related issues (73.8%), blurry vision (69.0%), and light sensitivity (66.7%) were the most common symptoms. Patients with reading-related issues showed a higher level of eye strain (p<0.001). Neuro-visual deficits were found in 83.3% of the patients, mainly concerning eye teaming (23.1%-66.7%) and eye movement (28.6%-30.8%) functions. Patients with vision-related symptoms reported fatigue and 18 other co-existing symptoms to a greater extent (p\u22640.0001 to 0.049).\n\nNeuro-visual symptoms and signs should be considered when assessing rehabilitation needs after Covid-19. The association between vision-related issues and co-existing symptoms with an impact on body function and activity/participation underlines the need for multi-professional rehabilitation assessment and intervention.", "doi": "10.1016/j.arrct.2022.100184", "pmid": "35128374", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2590-1095(22)00007-6"}, {"db": "pmc", "key": "PMC8802546"}], "notes": [], "created": "2022-02-08T15:15:20.652Z", "modified": "2022-02-08T15:15:20.658Z"}, {"entity": "publication", "iuid": "b4ec75c22fa64badaf91848a344c0ae3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b4ec75c22fa64badaf91848a344c0ae3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b4ec75c22fa64badaf91848a344c0ae3"}}, "title": "Integrated Sustainable childhood Pneumonia and Infectious disease Reduction in Nigeria (INSPIRING) through whole system strengthening in Jigawa, Nigeria: study protocol for a cluster randomised controlled trial.", "authors": [{"family": "King", "given": "Carina", "initials": "C", "orcid": "0000-0002-6885-6716", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8ac349483b74803a39b937bf149c480.json"}}, {"family": "Burgess", "given": "Rochelle Ann", "initials": "RA"}, {"family": "Bakare", "given": "Ayobami A", "initials": "AA"}, {"family": "Shittu", "given": "Funmilayo", "initials": "F"}, {"family": "Salako", "given": "Julius", "initials": "J"}, {"family": "Bakare", "given": "Damola", "initials": "D"}, {"family": "Uchendu", "given": "Obioma C", "initials": "OC"}, {"family": "Iuliano", "given": "Agnese", "initials": "A"}, {"family": "Isah", "given": "Adamu", "initials": "A"}, {"family": "Adams", "given": "Osebi", "initials": "O"}, {"family": "Haruna", "given": "Ibrahim", "initials": "I"}, {"family": "Magama", "given": "Abdullahi", "initials": "A"}, {"family": "Ahmed", "given": "Tahlil", "initials": "T"}, {"family": "Ahmar", "given": "Samy", "initials": "S"}, {"family": "Cassar", "given": "Christine", "initials": "C"}, {"family": "Valentine", "given": "Paula", "initials": "P"}, {"family": "Olowookere", "given": "Temitayo Folorunso", "initials": "TF"}, {"family": "MacCalla", "given": "Matthew", "initials": "M"}, {"family": "Graham", "given": "Hamish R", "initials": "HR"}, {"family": "McCollum", "given": "Eric D", "initials": "ED"}, {"family": "Falade", "given": "Adegoke G", "initials": "AG"}, {"family": "Colbourn", "given": "Tim", "initials": "T"}, {"family": "INSPIRING Project Consortium", "given": "", "initials": ""}], "type": "clinical trial protocol", "published": "2022-01-31", "journal": {"title": "Trials", "issn": "1745-6215", "volume": "23", "issue": "1", "pages": "95", "issn-l": null}, "abstract": "Child mortality remains unacceptably high, with Northern Nigeria reporting some of the highest rates globally (e.g. 192/1000 live births in Jigawa State). Coverage of key protect and prevent interventions, such as vaccination and clean cooking fuel use, is low. Additionally, knowledge, care-seeking and health system factors are poor. Therefore, a whole systems approach is needed for sustainable reductions in child mortality.\n\nThis is a cluster randomised controlled trial, with integrated process and economic evaluations, conducted from January 2021 to September 2022. The trial will be conducted in Kiyawa Local Government Area, Jigawa State, Nigeria, with an estimated population of 230,000. Clusters are defined as primary government health facility catchment areas (n = 33). The 33 clusters will be randomly allocated (1:1) in a public ceremony, and 32 clusters included in the impact evaluation. The trial will evaluate a locally adapted 'whole systems strengthening' package of three evidence-based methods: community men's and women's groups, Partnership Defined Quality Scorecard and healthcare worker training, mentorship and provision of basic essential equipment and commodities. The primary outcome is mortality of children aged 7 days to 59 months. Mortality will be recorded prospectively using a cohort design, and secondary outcomes measured through baseline and endline cross-sectional surveys. Assuming the following, we will have a minimum detectable effect size of 30%: (a) baseline mortality of 100 per 1000 livebirths, (b) 4480 compounds with 3 eligible children per compound, (c) 80% power, (d) 5% significance, (e) intra-cluster correlation of 0.007 and (f) coefficient of variance of cluster size of 0.74. Analysis will be by intention-to-treat, comparing intervention and control clusters, adjusting for compound and trial clustering.\n\nThis study will provide robust evidence of the effectiveness and cost-effectiveness of community-based participatory learning and action, with integrated health system strengthening and accountability mechanisms, to reduce child mortality. The ethnographic process evaluation will allow for a rich understanding of how the intervention works in this context. However, we encountered a key challenge in calculating the sample size, given the lack of timely and reliable mortality data and the uncertain impacts of the COVID-19 pandemic.\n\nISRCTN 39213655 . Registered on 11 December 2019.", "doi": "10.1186/s13063-021-05859-5", "pmid": "35101109", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13063-021-05859-5"}, {"db": "pmc", "key": "PMC8802253"}], "notes": [], "created": "2022-02-06T16:52:28.794Z", "modified": "2022-02-06T16:52:28.819Z"}, {"entity": "publication", "iuid": "4605d61423c84be6a37ba9454a1991a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4605d61423c84be6a37ba9454a1991a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4605d61423c84be6a37ba9454a1991a9"}}, "title": "Global case fatality rate of coronavirus disease 2019 (COVID-19) by continents and national income: a meta-analysis.", "authors": [{"family": "Ghayda", "given": "Ramy Abou", "initials": "RA"}, {"family": "Lee", "given": "Keum Hwa", "initials": "KH"}, {"family": "Han", "given": "Young Joo", "initials": "YJ"}, {"family": "Ryu", "given": "Seohyun", "initials": "S"}, {"family": "Hong", "given": "Sung Hwi", "initials": "SH"}, {"family": "Yoon", "given": "Sojung", "initials": "S"}, {"family": "Jeong", "given": "Gwang Hun", "initials": "GH"}, {"family": "Yang", "given": "Jae Won", "initials": "JW"}, {"family": "Lee", "given": "Hyo Jeong", "initials": "HJ"}, {"family": "Lee", "given": "Jinhee", "initials": "J"}, {"family": "Lee", "given": "Jun Young", "initials": "JY"}, {"family": "Effenberger", "given": "Maria", "initials": "M"}, {"family": "Eisenhut", "given": "Michael", "initials": "M"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Solmi", "given": "Marco", "initials": "M"}, {"family": "Li", "given": "Han", "initials": "H"}, {"family": "Jacob", "given": "Louis", "initials": "L"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Park", "given": "Myung Bae", "initials": "MB"}, {"family": "Aghayeva", "given": "Sevda", "initials": "S"}, {"family": "Ahmed", "given": "Mohamed Lemine Cheikh Brahim", "initials": "MLCB"}, {"family": "Serouri", "given": "Abdulwahed Al", "initials": "AA"}, {"family": "Al-Shamsi", "given": "Humaid O", "initials": "HO"}, {"family": "Amir-Behghadami", "given": "Mehrdad", "initials": "M"}, {"family": "Baatarkhuu", "given": "Oidov", "initials": "O"}, {"family": "Bashour", "given": "Hyam", "initials": "H"}, {"family": "Bondarenko", "given": "Anastasiia", "initials": "A"}, {"family": "Camacho-Ortiz", "given": "Adrian", "initials": "A"}, {"family": "Castro", "given": "Franz", "initials": "F"}, {"family": "Cox", "given": "Horace", "initials": "H"}, {"family": "Davtyan", "given": "Hayk", "initials": "H"}, {"family": "Douglas", "given": "Kirk", "initials": "K"}, {"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Ebrahim", "given": "Shahul", "initials": "S"}, {"family": "Ferioli", "given": "Martina", "initials": "M"}, {"family": "Harapan", "given": "Harapan", "initials": "H"}, {"family": "Mallah", "given": "Saad I", "initials": "SI"}, {"family": "Ikram", "given": "Aamer", "initials": "A"}, {"family": "Inoue", "given": "Shigeru", "initials": "S"}, {"family": "Jankovic", "given": "Slobodan", "initials": "S"}, {"family": "Jayarajah", "given": "Umesh", "initials": "U", "orcid": "0000-0002-0398-5197", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0bea00924415424fa7972f7aef4788f1.json"}}, {"family": "Jesenak", "given": "Milos", "initials": "M"}, {"family": "Kakodkar", "given": "Pramath", "initials": "P"}, {"family": "Kebede", "given": "Yohannes", "initials": "Y"}, {"family": "Kifle", "given": "Meron", "initials": "M"}, {"family": "Koh", "given": "David", "initials": "D"}, {"family": "Males", "given": "Visnja Kokic", "initials": "VK"}, {"family": "Kotfis", "given": "Katarzyna", "initials": "K"}, {"family": "Lakoh", "given": "Sulaiman", "initials": "S"}, {"family": "Ling", "given": "Lowell", "initials": "L"}, {"family": "Llibre-Guerra", "given": "Jorge", "initials": "J"}, {"family": "Machida", "given": "Masaki", "initials": "M"}, {"family": "Makurumidze", "given": "Richard", "initials": "R"}, {"family": "Mamun", "given": "Mohammed", "initials": "M", "orcid": "0000-0002-1728-8966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6e65a5a97154d159a63cc2ce3f1b7a8.json"}}, {"family": "Masic", "given": "Izet", "initials": "I"}, {"family": "Van Minh", "given": "Hoang", "initials": "H"}, {"family": "Moiseev", "given": "Sergey", "initials": "S"}, {"family": "Nadasdy", "given": "Thomas", "initials": "T"}, {"family": "Nahshon", "given": "Chen", "initials": "C"}, {"family": "\u00d1amendys-Silva", "given": "Silvio A", "initials": "SA"}, {"family": "Yongsi", "given": "Blaise Nguendo", "initials": "BN"}, {"family": "Nielsen", "given": "Henning Bay", "initials": "HB"}, {"family": "Nodjikouambaye", "given": "Zita Aleyo", "initials": "ZA"}, {"family": "Ohnmar", "given": "Ohnmar", "initials": "O"}, {"family": "Oksanen", "given": "Atte", "initials": "A", "orcid": "0000-0003-4143-5580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ad67f37abe44c1aa0e75421648cfb0d.json"}}, {"family": "Owopetu", "given": "Oluwatomi", "initials": "O"}, {"family": "Parperis", "given": "Konstantinos", "initials": "K"}, {"family": "Perez", "given": "Gonzalo Emanuel", "initials": "GE"}, {"family": "Pongpirul", "given": "Krit", "initials": "K"}, {"family": "Rademaker", "given": "Marius", "initials": "M"}, {"family": "Rosa", "given": "Sandro", "initials": "S"}, {"family": "Sah", "given": "Ranjit", "initials": "R"}, {"family": "Sallam", "given": "Dina", "initials": "D"}, {"family": "Schober", "given": "Patrick", "initials": "P"}, {"family": "Singhal", "given": "Tanu", "initials": "T"}, {"family": "Tafaj", "given": "Silva", "initials": "S"}, {"family": "Torres", "given": "Irene", "initials": "I"}, {"family": "Smith Torres-Roman", "given": "J", "initials": "J"}, {"family": "Tsartsalis", "given": "Dimitrios", "initials": "D"}, {"family": "Tsolmon", "given": "Jadamba", "initials": "J"}, {"family": "Tuychiev", "given": "Laziz", "initials": "L"}, {"family": "Vukcevic", "given": "Batric", "initials": "B"}, {"family": "Wanghi", "given": "Guy", "initials": "G"}, {"family": "Wollina", "given": "Uwe", "initials": "U"}, {"family": "Xu", "given": "Ren-He", "initials": "R"}, {"family": "Yang", "given": "Lin", "initials": "L"}, {"family": "Zaidi", "given": "Zoubida", "initials": "Z"}, {"family": "Smith", "given": "Lee", "initials": "L"}, {"family": "Shin", "given": "Jae Il", "initials": "JI", "orcid": "0000-0003-2326-1820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ca450cb43e3478d81ba93be745f0ea0.json"}}], "type": "journal article", "published": "2022-01-31", "journal": {"title": "J Med Virol", "issn": "1096-9071", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The aim of this study is to provide a more accurate representation of COVID-19's CFR by performing meta-analyses by continents and income, and by comparing the result with pooled estimates. We used multiple worldwide data sources on COVID-19 for every country reporting COVID-19 cases. Based on the data, we performed random and fixed meta-analyses for CFR of COVID-19 by continents and income according to each individual calendar date. CFR were estimated based on the different geographical regions and level of income using three models: pooled estimates, fixed- and random-model. In Asia, all three types of CFR initially remained approximately between 2.0% and 3.0%. In the case of pooled estimates and the fixed model results, CFR increased to 4.0%, by then gradually decreasing, while in the case of random-model, CFR remained under 2.0%. Similarly, in Europe, initially the two types of CFR peaked at 9.0% and 10.0%, respectively. The random-model results showed an increase near 5.0%. In high income countries, pooled estimates and fixed-model showed gradually increasing trends with a final pooled estimates and random-model reached about 8.0% and 4.0%, respectively. In middle-income, the pooled estimates and fixed-model have gradually increased reaching up to 4.5%. in low-income countries, CFRs remained similar between 1.5% and 3.0%. Our study emphasizes that COVID-19 CFR is not a fixed or static value. Rather, it is a dynamic estimate that changes with time, population, socioeconomic factors and the mitigatory efforts of individuals countries. This article is protected by copyright. All rights reserved.", "doi": "10.1002/jmv.27610", "pmid": "35099819", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-06T16:54:07.571Z", "modified": "2022-02-06T16:54:40.249Z"}, {"entity": "publication", "iuid": "05cec7cdf3064c9c9162018fddda120d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/05cec7cdf3064c9c9162018fddda120d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/05cec7cdf3064c9c9162018fddda120d"}}, "title": "Evaluation serum levels of Insulin Growth Factor-1 (IGF-1) and its association with clinical parameters in severe COVID-19.", "authors": [{"family": "Feizollahi", "given": "Parisa", "initials": "P"}, {"family": "Matin", "given": "Somaieh", "initials": "S"}, {"family": "Roghani", "given": "Seyed Askar", "initials": "SA"}, {"family": "Mostafaei", "given": "Shayan", "initials": "S"}, {"family": "Safarzadeh", "given": "Elham", "initials": "E"}, {"family": "Taghadosi", "given": "Mahdi", "initials": "M", "orcid": "0000-0002-3516-0130", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f30112bc6d6140479d16934f5223e9a4.json"}}], "type": "journal article", "published": "2022-01-31", "journal": {"title": "Inflammopharmacology", "issn": "1568-5608", "issn-l": null}, "abstract": "Severe coronavirus disease-2019 (COVID-19) is associated with dysregulated immune response and extreme inflammatory injury. Considering the role of insulin growth factor-1 (IGF-1) in immune-mediated and inflammatory reactions, this study was conducted to investigate the IGF-1 contribution to the pathogenesis of severe form of COVID-19.\n\nSixty-two patients with severe COVID-19 and 52 healthy subjects were enrolled in this study. The serum levels of IGF-1 were measured using a solid-phase enzyme-linked chemiluminescent immunoassay on an Immulite 2000 system (Siemens Healthcare Diagnostics.\n\nThe serum levels of IGF-1 had no significant difference in COVID-19 patients compared to the healthy subjects (p = 0.359). There was a positive correlation between IGF-1 and age in the severe COVID-19 patients, while a negative correlation was observed for the serum levels of IGF-1 and age in the control group (r = 0.364, p = 0.036, r = - 0.536, p = 0.001, respectively). Moreover, IGF-1 was remarkably associated with hypertension, neurogenic disease, shock, and nausea in patients with the severe form of COVID-19 (p = 0.031, p = 0.044, p = 0.01, p = 0.03, respectively).\n\nOur results pointed to the complex role of IGF-1 in the severe form of COVID-19, and its association with clinical parameters, and some risk factors in the severe form of COVID-19.", "doi": "10.1007/s10787-021-00908-6", "pmid": "35098386", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10787-021-00908-6"}, {"db": "pmc", "key": "PMC8801278"}], "notes": [], "created": "2022-02-06T16:55:44.236Z", "modified": "2022-02-06T16:55:44.304Z"}, {"entity": "publication", "iuid": "b56709f19e1e42c5b849ae05e968851d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b56709f19e1e42c5b849ae05e968851d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b56709f19e1e42c5b849ae05e968851d"}}, "title": "Bacterial co-infections in community-acquired pneumonia caused by SARS-CoV-2, influenza virus and respiratory syncytial virus.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P"}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Ternhag", "given": "Anders", "initials": "A"}, {"family": "Abdel-Halim", "given": "Lina", "initials": "L"}, {"family": "Hedlund", "given": "Jonas", "initials": "J"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2022-01-31", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "volume": "22", "issue": "1", "pages": "108", "issn-l": null}, "abstract": "A mismatch between a widespread use of broad-spectrum antibiotic agents and a low prevalence of reported bacterial co-infections in patients with SARS-CoV-2 infections has been observed. Herein, we sought to characterize and compare bacterial co-infections at admission in hospitalized patients with SARS-CoV-2, influenza or respiratory syncytial virus (RSV) positive community-acquired pneumonia (CAP).\n\nA retrospective cohort study of bacterial co-infections at admission in SARS-CoV-2, influenza or RSV-positive adult patients with CAP admitted to Karolinska University Hospital in Stockholm, Sweden, from year 2011 to 2020. The prevalence of bacterial co-infections was investigated and compared between the three virus groups. In each virus group, length of stay, ICU-admission and 30-day mortality was compared in patients with and without bacterial co-infection, adjusting for age, sex and co-morbidities. In the SARS-CoV-2 group, risk factors for bacterial co-infection, were assessed using logistic regression models and creation of two scoring systems based on disease severity, age, co-morbidities and inflammatory markers with assessment of concordance statistics.\n\nCompared to influenza and RSV, the bacterial co-infection testing frequency in SARS-CoV-2 was lower for all included test modalities. Four percent [46/1243 (95% CI 3-5)] of all SARS-CoV-2 patients had a bacterial co-infection at admission, whereas the proportion was 27% [209/775 (95% CI 24-30)] and 29% [69/242 (95% CI 23-35)] in influenza and RSV, respectively. S. pneumoniae and S. aureus constituted the most common bacterial findings for all three virus groups. Comparing SARS-CoV-2 positive patients with and without bacterial co-infection at admission, a relevant association could not be demonstrated nor excluded with regards to risk of ICU-admission (aHR 1.53, 95% CI 0.87-2.69) or 30-day mortality (aHR 1.28, 95% CI 0.66-2.46) in adjusted analyses. Bacterial co-infection was associated with increased inflammatory markers, but the diagnostic accuracy was not substantially different in a scoring system based on disease severity, age, co-morbidities and inflammatory parameters [C statistic 0.66 (95% CI 0.59-0.74)], compared to using disease severity, age and co-morbidities only [C statistic 0.63 (95% CI 0.56-0.70)].\n\nThe prevalence of bacterial co-infections was significantly lower in patients with community-acquired SARS-CoV-2 positive pneumonia as compared to influenza and RSV positive pneumonia.", "doi": "10.1186/s12879-022-07089-9", "pmid": "35100984", "labels": {"Category: Health": null, "Type: Journal article": null, "Funder: Vinnova": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12879-022-07089-9"}, {"db": "pmc", "key": "PMC8802536"}], "notes": [], "created": "2022-02-06T16:52:51.200Z", "modified": "2022-02-06T16:53:31.048Z"}, {"entity": "publication", "iuid": "a5fae45113934b8bb907e66a3b263b48", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a5fae45113934b8bb907e66a3b263b48.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a5fae45113934b8bb907e66a3b263b48"}}, "title": "Assessing How Consumers Interpret and Act on Results From At-Home COVID-19 Self-test Kits: A Randomized Clinical Trial.", "authors": [{"family": "Woloshin", "given": "Steven", "initials": "S"}, {"family": "Dewitt", "given": "Barry", "initials": "B"}, {"family": "Krishnamurti", "given": "Tamar", "initials": "T"}, {"family": "Fischhoff", "given": "Baruch", "initials": "B"}], "type": "journal article", "published": "2022-01-31", "journal": {"title": "JAMA Intern Med", "issn": "2168-6114", "issn-l": null}, "abstract": "The US Food and Drug Administration (FDA) authorized SARS-CoV-2 rapid at-home self-test kits for individuals with and without symptoms. How appropriately users interpret and act on the results of at-home COVID-19 self-tests is unknown.\n\nTo assess how users of at-home COVID-19 self-test kits interpret and act on results when given instructions authorized by the FDA, instructions based on decision science principles, or no instructions.\n\nA randomized clinical trial was conducted of 360 adults in the US who were recruited in April 2021 to complete an online survey on their interpretation of at-home COVID-19 self-test results. Participants were given 1 of 3 instruction types and were presented with 1 of 4 risk scenarios. Participants were paid $5 and had a median survey completion time of 8.7 minutes. Data analyses were performed from June to July 2021.\n\nParticipants were randomized to receiving either the FDA-authorized instructions (authorized), the intervention instructions (intervention), or no instructions (control), and to 1 of 4 scenarios: 3 with a high pretest probability of infection (COVID-19 symptoms and/or a close contact with COVID-19) and 1 with low pretest probability (no symptoms and no contact). The intervention instructions were designed using decision science principles.\n\nProportion of participants in the high pretest probability scenarios choosing to quarantine per federal recommendations and perceived probabilities of infection given a negative or positive COVID-19 test result. A Bonferroni correction accounted for multiple comparisons (3 instruction types \u00d7 4 scenarios; \u03b1 = 0.004).\n\nAfter excluding 22 individuals who completed the survey too quickly, the responses of 338 participants (median [IQR] age, 38 [31 to 48] years; 154 (46%) women; 215 (64%) with a college degree or higher) were included in the study analysis. Given a positive test result, 95% (322 of 338; 95% CI, 0.92 to 0.97) of the total participants appropriately chose to quarantine regardless of which instructions they had received. Given a negative test result, participants in the high pretest probability scenarios were more likely to fail to quarantine appropriately with the authorized instructions (33%) than with the intervention (14%; 95% CI for the 19% difference, 6% to 31%; P = .004) or control (24%; 95% CI for the 9% difference, -4% to 23%; P = .02). In the low pretest probability scenario, the proportion choosing unnecessary quarantine was higher with the authorized instructions (31%) than with the intervention (22%; 95% CI for the 9% difference, -14% to 31%) or control (10%; 95% CI for the 21% difference, 0.5% to 41%)-neither comparison was statistically significant (P = .05 and P = .20 respectively).\n\nThe findings of this randomized clinical trial indicate that at-home COVID-19 self-test kit users relying on the authorized instructions may not follow the Centers for Disease Control and Prevention's quarantine recommendations, producing unintended risks and unnecessary disruptions. Redesigned instructions that follow decision science principles may improve compliance.\n\nClinicalTrials.gov Identifier: NCT04758299.", "doi": "10.1001/jamainternmed.2021.8075", "pmid": "35099501", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "2788656"}, {"db": "ClinicalTrials.gov", "key": "NCT04758299"}], "notes": [], "created": "2022-02-06T16:54:52.435Z", "modified": "2022-02-06T16:55:06.381Z"}, {"entity": "publication", "iuid": "93039f55bd154261b34650b56b1ce76f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/93039f55bd154261b34650b56b1ce76f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/93039f55bd154261b34650b56b1ce76f"}}, "title": "An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection.", "authors": [{"family": "Sanchez-Burgos", "given": "Laura", "initials": "L"}, {"family": "G\u00f3mez-L\u00f3pez", "given": "Gonzalo", "initials": "G"}, {"family": "Al-Shahrour", "given": "F\u00e1tima", "initials": "F"}, {"family": "Fernandez-Capetillo", "given": "Oscar", "initials": "O"}], "type": "journal article", "published": "2022-01-31", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "12", "issue": "1", "pages": "1626"}, "abstract": "The ongoing COVID-19 pandemic is one of the biggest health challenges of recent decades. Among the causes of mortality triggered by SARS-CoV-2 infection, the development of an inflammatory \"cytokine storm\" (CS) plays a determinant role. Here, we used transcriptomic data from the bronchoalveolar lavage fluid (BALF) of COVID-19 patients undergoing a CS to obtain gene-signatures associated to this pathology. Using these signatures, we interrogated the Connectivity Map (CMap) dataset that contains the effects of over 5000 small molecules on the transcriptome of human cell lines, and looked for molecules which effects on transcription mimic or oppose those of the CS. As expected, molecules that potentiate immune responses such as PKC activators are predicted to worsen the CS. In addition, we identified the negative regulation of female hormones among pathways potentially aggravating the CS, which helps to understand the gender-related differences in COVID-19 mortality. Regarding drugs potentially counteracting the CS, we identified glucocorticoids as a top hit, which validates our approach as this is the primary treatment for this pathology. Interestingly, our analysis also reveals a potential effect of MEK inhibitors in reverting the COVID-19 CS, which is supported by in vitro data that confirms the anti-inflammatory properties of these compounds.", "doi": "10.1038/s41598-022-05597-x", "pmid": "35102208", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-05597-x"}], "notes": [], "created": "2022-02-04T16:00:23.387Z", "modified": "2022-02-04T16:02:21.636Z"}, {"entity": "publication", "iuid": "fe7406372e8d41658b99738bd1fd23cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fe7406372e8d41658b99738bd1fd23cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fe7406372e8d41658b99738bd1fd23cc"}}, "title": "Seek COVER: using a disease proxy to rapidly develop and validate a personalized risk calculator for COVID-19 outcomes in an international network.", "authors": [{"family": "Williams", "given": "Ross D", "initials": "RD"}, {"family": "Markus", "given": "Aniek F", "initials": "AF"}, {"family": "Yang", "given": "Cynthia", "initials": "C"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "DuVall", "given": "Scott L", "initials": "SL"}, {"family": "Falconer", "given": "Thomas", "initials": "T"}, {"family": "Jonnagaddala", "given": "Jitendra", "initials": "J"}, {"family": "Kim", "given": "Chungsoo", "initials": "C"}, {"family": "Rho", "given": "Yeunsook", "initials": "Y"}, {"family": "Williams", "given": "Andrew E", "initials": "AE"}, {"family": "Machado", "given": "Amanda Alberga", "initials": "AA"}, {"family": "An", "given": "Min Ho", "initials": "MH"}, {"family": "Arag\u00f3n", "given": "Mar\u00eda", "initials": "M"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Burn", "given": "Edward", "initials": "E"}, {"family": "Choi", "given": "Young Hwa", "initials": "YH"}, {"family": "Drakos", "given": "Iannis", "initials": "I"}, {"family": "Abrah\u00e3o", "given": "Maria Tereza Fernandes", "initials": "MTF"}, {"family": "Fern\u00e1ndez-Bertol\u00edn", "given": "Sergio", "initials": "S"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Kaas-Hansen", "given": "Benjamin Skov", "initials": "BS"}, {"family": "Kandukuri", "given": "Prasanna L", "initials": "PL"}, {"family": "Kors", "given": "Jan A", "initials": "JA"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Liaw", "given": "Siaw-Teng", "initials": "ST"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Machnicki", "given": "Gerardo", "initials": "G"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Morales", "given": "Daniel", "initials": "D"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Park", "given": "Rae Woong", "initials": "RW"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A"}, {"family": "Pratt", "given": "Nicole", "initials": "N"}, {"family": "Rao", "given": "Gowtham", "initials": "G"}, {"family": "Reich", "given": "Christian G", "initials": "CG"}, {"family": "Rivera", "given": "Marcela", "initials": "M"}, {"family": "Seinen", "given": "Tom", "initials": "T"}, {"family": "Shoaibi", "given": "Azza", "initials": "A"}, {"family": "Spotnitz", "given": "Matthew E", "initials": "ME"}, {"family": "Steyerberg", "given": "Ewout W", "initials": "EW"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhou", "given": "Lili", "initials": "L"}, {"family": "Ryan", "given": "Patrick B", "initials": "PB"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Reps", "given": "Jenna M", "initials": "JM"}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR"}], "type": "journal article", "published": "2022-01-30", "journal": {"title": "BMC Med Res Methodol", "issn": "1471-2288", "volume": "22", "issue": "1", "pages": "35", "issn-l": null}, "abstract": "We investigated whether we could use influenza data to develop prediction models for COVID-19 to increase the speed at which prediction models can reliably be developed and validated early in a pandemic. We developed COVID-19 Estimated Risk (COVER) scores that quantify a patient's risk of hospital admission with pneumonia (COVER-H), hospitalization with pneumonia requiring intensive services or death (COVER-I), or fatality (COVER-F) in the 30-days following COVID-19 diagnosis using historical data from patients with influenza or flu-like symptoms and tested this in COVID-19 patients.\n\nWe analyzed a federated network of electronic medical records and administrative claims data from 14 data sources and 6 countries containing data collected on or before 4/27/2020. We used a 2-step process to develop 3 scores using historical data from patients with influenza or flu-like symptoms any time prior to 2020. The first step was to create a data-driven model using LASSO regularized logistic regression, the covariates of which were used to develop aggregate covariates for the second step where the COVER scores were developed using a smaller set of features. These 3 COVER scores were then externally validated on patients with 1) influenza or flu-like symptoms and 2) confirmed or suspected COVID-19 diagnosis across 5 databases from South Korea, Spain, and the United States. Outcomes included i) hospitalization with pneumonia, ii) hospitalization with pneumonia requiring intensive services or death, and iii) death in the 30 days after index date.\n\nOverall, 44,507 COVID-19 patients were included for model validation. We identified 7 predictors (history of cancer, chronic obstructive pulmonary disease, diabetes, heart disease, hypertension, hyperlipidemia, kidney disease) which combined with age and sex discriminated which patients would experience any of our three outcomes. The models achieved good performance in influenza and COVID-19 cohorts. For COVID-19 the AUC ranges were, COVER-H: 0.69-0.81, COVER-I: 0.73-0.91, and COVER-F: 0.72-0.90. Calibration varied across the validations with some of the COVID-19 validations being less well calibrated than the influenza validations.\n\nThis research demonstrated the utility of using a proxy disease to develop a prediction model. The 3 COVER models with 9-predictors that were developed using influenza data perform well for COVID-19 patients for predicting hospitalization, intensive services, and fatality. The scores showed good discriminatory performance which transferred well to the COVID-19 population. There was some miscalibration in the COVID-19 validations, which is potentially due to the difference in symptom severity between the two diseases. A possible solution for this is to recalibrate the models in each location before use.", "doi": "10.1186/s12874-022-01505-z", "pmid": "35094685", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8801189"}, {"db": "pii", "key": "10.1186/s12874-022-01505-z"}], "notes": [], "created": "2022-02-06T17:04:47.177Z", "modified": "2023-06-19T15:02:04.233Z"}, {"entity": "publication", "iuid": "5ff0cd52aeff4d118b9046cb52f729a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5ff0cd52aeff4d118b9046cb52f729a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5ff0cd52aeff4d118b9046cb52f729a9"}}, "title": "The experiences of early career geriatricians throughout Europe during the COVID-19 pandemic.", "authors": [{"family": "Mezera", "given": "Vojtech", "initials": "V", "orcid": "0000-0002-8679-5208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53a0de0cbddb4ee8b35b5c6302159732.json"}}, {"family": "Ekdahl", "given": "Anne W", "initials": "AW"}, {"family": "Bertschi", "given": "Dominic", "initials": "D"}, {"family": "Bonnici", "given": "Maria", "initials": "M"}, {"family": "Buzaco", "given": "Rui", "initials": "R"}, {"family": "Rodeles", "given": "Santiago Cotobal", "initials": "SC"}, {"family": "Eruslanova", "given": "Kseniia", "initials": "K"}, {"family": "Matchekhina", "given": "Lubov", "initials": "L"}, {"family": "Bazan", "given": "Laura Monica Perez", "initials": "LMP"}, {"family": "Epelde", "given": "Itxaso Marin", "initials": "IM"}, {"family": "Kotsani", "given": "Marina", "initials": "M"}, {"family": "Femminella", "given": "Grazia Daniela", "initials": "GD"}, {"family": "Koca", "given": "Meltem", "initials": "M"}, {"family": "Dejaeger", "given": "Marian", "initials": "M"}], "type": "journal article", "published": "2022-01-29", "journal": {"title": "Eur Geriatr Med", "issn": "1878-7649", "issn-l": null}, "abstract": "The COVID-19 pandemic has severely affected older adults and brought about unprecedented challenges to geriatricians. We aimed to evaluate the experiences of early career geriatricians (residents or consultants with up to 10 years of experience) throughout Europe using an online survey. We obtained 721 responses. Most of the respondents were females (77.8%) and residents in geriatric medicine (54.6%). The majority (91.4%) were directly involved in the care of patients with COVID-19. The respondents reported moderate levels of anxiety and feelings of being overloaded with work. The anxiety levels were higher in women than in men. Most of the respondents experienced a feeling of a strong restriction on their private lives and a change in their work routine. The residents also reported a moderate disruption in their training and research activities. In conclusion, early career geriatricians experienced a major impact of COVID-19 on their professional and private lives.", "doi": "10.1007/s41999-021-00605-1", "pmid": "35091891", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s41999-021-00605-1"}], "notes": [], "created": "2022-01-31T11:42:19.651Z", "modified": "2022-01-31T11:42:19.721Z"}, {"entity": "publication", "iuid": "98c961ceb77b450cbb159b7679a93ff0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/98c961ceb77b450cbb159b7679a93ff0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/98c961ceb77b450cbb159b7679a93ff0"}}, "title": "The impact of Covid-19 on the initiation of clinical trials in Europe and the United States.", "authors": [{"family": "Lasch", "given": "Florian", "initials": "F"}, {"family": "Psarelli", "given": "Eftychia-Eirini", "initials": "EE"}, {"family": "Herold", "given": "Ralf", "initials": "R"}, {"family": "Mattsson", "given": "Andrea", "initials": "A"}, {"family": "Guizzaro", "given": "Lorenzo", "initials": "L"}, {"family": "P\u00e9tavy", "given": "Frank", "initials": "F"}, {"family": "Schiel", "given": "Anja", "initials": "A"}], "type": "journal article", "published": "2022-01-28", "journal": {"title": "Clin Pharmacol Ther", "issn": "1532-6535", "issn-l": null}, "abstract": "The Covid-19 pandemic has a major impact not only on public health and daily living, but also on clinical trials worldwide. To investigate the potential impact of the Covid-19 pandemic on the initiation of clinical trials, we have descriptively analysed the longitudinal change in phase II and III interventional clinical trials initiated in Europe and in the United States. Based on the public clinical trial register EU Clinical Trials Register and clinicaltrials.gov, we conducted (a) a yearly comparison of the number of initiated trials from 2010 to 2020 and (b) a monthly comparison from January 2020 to February 2021 of the number of initiated trials. The analyses indicate that the Covid-19 pandemic affected both the initiation of clinical trials overall and the initiation of non-Covid-19 trials. An increase in the overall numbers of clinical trials could be observed both in Europe and the US in 2020 as compared to 2019. However, the number of non-Covid-19 trials initiated is reduced as compared to the previous decade, with a slightly larger relative decrease in the US as compared to Europe. Additionally, the monthly trend for the initiation of non-Covid-19 trials differs between regions. In the US, after a sharp decrease in April 2020, trial numbers reached the levels of 2019 from June 2020 onwards. In Europe, the decrease was less pronounced, but trial numbers mainly remained below the 2019 average until February 2021.", "doi": "10.1002/cpt.2534", "pmid": "35090044", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-31T11:43:04.018Z", "modified": "2022-01-31T11:43:04.042Z"}, {"entity": "publication", "iuid": "f26455ac99bd45c1a392a3fbd85b2979", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f26455ac99bd45c1a392a3fbd85b2979.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f26455ac99bd45c1a392a3fbd85b2979"}}, "title": "Social Skills Group Training for Students with Neurodevelopmental Disabilities in Senior High School-A Qualitative Multi-Perspective Study of Social Validity.", "authors": [{"family": "Leifler", "given": "Emma", "initials": "E", "orcid": "0000-0001-5007-0996", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61adfbe1d8e64ceab6c076053cb6ad94.json"}}, {"family": "Coco", "given": "Christina", "initials": "C", "orcid": "0000-0001-7963-8637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29565879a0ef4cb088318d41df64b633.json"}}, {"family": "Fridell", "given": "Anna", "initials": "A"}, {"family": "Borg", "given": "Anna", "initials": "A"}, {"family": "B\u00f6lte", "given": "Sven", "initials": "S"}], "type": "journal article", "published": "2022-01-28", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "3", "issn-l": null}, "abstract": "Including students with neurodevelopmental disabilities (NDDs) in regular classrooms has become a law-enforced common practice in many high- and middle-income countries. Still, without appropriate actions supporting the implementation of inclusive pedagogical practice, students with NDDs remain at increased risk for absenteeism, bullying and underachievement. There is limited knowledge on the feasibility of social skills group training (SSGT) in naturalistic settings. Using a qualitative approach, the objective of this study was to explore the lived experiences of (i) students diagnosed with autism or attention-deficit hyperactivity disorder and those showing subclinical social difficulties receiving either SSGT or active social control activities in a regular senior high school setting, (ii) teachers providing SSGT or the active control activity and (iii) school leaders facilitating the implementation of these actions. Due to the impact of the COVID-19 pandemic, comparison between real life versus digital administration of SSGT was also examined. Within a randomized controlled pilot trial of the school-tailored SSGT SKOLKONTAKT\u00ae, the primary perspectives of 20 students, teachers and school leaders on SSGT or the social control activities were explored. All groups perceived SSGT to enhance school attendance and academic achievement of students, as well as teacher inclusion skills and the social school climate. Findings indicate that SSGT is largely feasible and socially valid, and broader implementation of SSGT in school settings appears meaningful.", "doi": "10.3390/ijerph19031487", "pmid": "35162512", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph19031487"}], "notes": [], "created": "2022-02-17T06:09:18.094Z", "modified": "2022-02-17T06:09:18.193Z"}, {"entity": "publication", "iuid": "c9bcbac993ca42218a2c39ff2598c89c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9bcbac993ca42218a2c39ff2598c89c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9bcbac993ca42218a2c39ff2598c89c"}}, "title": "Inherited IFNAR1 Deficiency in a Child with Both Critical COVID-19 Pneumonia and Multisystem Inflammatory Syndrome.", "authors": [{"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Landegren", "given": "Nils", "initials": "N"}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Materna", "given": "Marie", "initials": "M"}, {"family": "Modaresi", "given": "Mohammadreza", "initials": "M"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Aranda-Guill\u00e9n", "given": "Maribel", "initials": "M"}, {"family": "Sardh", "given": "Fabian", "initials": "F"}, {"family": "Zuo", "given": "Fanglei", "initials": "F"}, {"family": "Zhang", "given": "Peng", "initials": "P"}, {"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Marr", "given": "Nico", "initials": "N"}, {"family": "Khan", "given": "Taushif", "initials": "T"}, {"family": "Ata", "given": "Manar", "initials": "M"}, {"family": "Al-Ali", "given": "Fatima", "initials": "F"}, {"family": "Pescarmona", "given": "Remi", "initials": "R"}, {"family": "Belot", "given": "Alexandre", "initials": "A"}, {"family": "B\u00e9ziat", "given": "Vivien", "initials": "V"}, {"family": "Zhang", "given": "Qian", "initials": "Q"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL"}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q", "orcid": "0000-0003-1990-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94a32366862b470eba3a15521b9be290.json"}}], "type": "journal article", "published": "2022-01-28", "journal": {"title": "J Clin Immunol", "issn": "1573-2592", "issn-l": "0271-9142"}, "abstract": "Inborn errors of immunity (IEI) and autoantibodies to type I interferons (IFNs) underlie critical COVID-19 pneumonia in at least 15% of the patients, while the causes of multisystem inflammatory syndrome in children (MIS-C) remain elusive.\n\nTo detect causal genetic variants in very rare cases with concomitant critical COVID-19 pneumonia and MIS-C.\n\nWhole exome sequencing was performed, and the impact of candidate gene variants was investigated. Plasma levels of cytokines, specific antibodies against the virus, and autoantibodies against type I IFNs were also measured.\n\nWe report a 3-year-old child who died on day 56 of SARS-CoV-2 infection with an unusual clinical presentation, combining both critical COVID-19 pneumonia and MIS-C. We identified a large, homozygous loss-of-function deletion in IFNAR1, underlying autosomal recessive IFNAR1 deficiency.\n\nOur findings confirm that impaired type I IFN immunity can underlie critical COVID-19 pneumonia, while suggesting that it can also unexpectedly underlie concomitant MIS-C. Our report further raises the possibility that inherited or acquired dysregulation of type I IFN immunity might contribute to MIS-C in other patients.", "doi": "10.1007/s10875-022-01215-7", "pmid": "35091979", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10875-022-01215-7"}], "notes": [], "created": "2022-01-31T11:41:50.645Z", "modified": "2022-01-31T11:41:50.669Z"}, {"entity": "publication", "iuid": "2de0e4d64ed54d4380102d6aba32653b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2de0e4d64ed54d4380102d6aba32653b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2de0e4d64ed54d4380102d6aba32653b"}}, "title": "Corrigendum to \"Error rates in SARS-CoV-2 testing examined with Bayes' theorem\" [Heliyon 7 (4), (April 2021) Article e06905].", "authors": [{"family": "Bentley", "given": "Phillip", "initials": "P"}], "type": "published erratum", "published": "2022-01-28", "journal": {"title": "Heliyon", "issn": "2405-8440", "pages": "e08836", "issn-l": null}, "abstract": "[This corrects the article DOI: 10.1016/j.heliyon.2021.e06905.].", "doi": "10.1016/j.heliyon.2022.e08836", "pmid": "35106385", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(22)00124-4"}, {"db": "pmc", "key": "PMC8795781"}], "notes": [], "created": "2022-02-06T16:50:42.414Z", "modified": "2022-02-06T16:50:42.429Z"}, {"entity": "publication", "iuid": "00f475c5a60449c68afa511f7dbbf937", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/00f475c5a60449c68afa511f7dbbf937.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/00f475c5a60449c68afa511f7dbbf937"}}, "title": "Social Work Responses to Domestic Violence During the COVID-19 Pandemic: Experiences and Perspectives of Professionals at Women's Shelters in Sweden.", "authors": [{"family": "Petersson", "given": "Charlotte C", "initials": "CC", "orcid": "0000-0002-2233-9297", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bef9293d9cfa49fb99a23232e1f8905e.json"}}, {"family": "Hansson", "given": "Kristofer", "initials": "K"}], "type": "journal article", "published": "2022-01-27", "journal": {"title": "Clin Soc Work J", "issn": "0091-1674", "issn-l": null, "volume": null, "issue": null, "pages": "1-12"}, "abstract": "This study explores how social work professionals at women's shelters in Sweden experience, understand, and are responding to domestic violence under the impact of the COVID-19 pandemic. A qualitative longitudinal research design was employed, and multiple semi-structured interviews were conducted with 14 professionals at women's shelters over a period of one year. The results are presented in three overall themes; (a) professional challenges due to increased needs, (b) professionals' adjustments to new circumstances, and (c) professionals' attributions regarding client barriers to help seeking. The results show diverse and changing experiences among the professionals as the pandemic progressed. Clients and professionals have shared the same collective trauma associated with the pandemic, which has affected the professionals' understanding of and response to domestic violence. The professionals understand both clients and themselves as being more vulnerable and susceptible to risk under these new circumstances. Social work adjustments focused on maintaining contact, reducing risk and prioritizing safety, which had both positive and negative consequences for both clients and professionals. The study concludes that the professionals coped with the uncertainty they experienced during the pandemic by relying on both their previous knowledge and work experience of domestic violence and their experience of sharing trauma with clients.", "doi": "10.1007/s10615-022-00833-3", "pmid": "35103027", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "833"}, {"db": "pmc", "key": "PMC8792516"}], "notes": [], "created": "2022-02-06T16:51:49.489Z", "modified": "2022-11-22T05:40:09.771Z"}, {"entity": "publication", "iuid": "393d6100ca964841b76331c427e6aa0c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/393d6100ca964841b76331c427e6aa0c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/393d6100ca964841b76331c427e6aa0c"}}, "title": "Risk factors for COVID-19-related death, hospitalization and intensive care: a population-wide study of all inhabitants in Stockholm.", "authors": [{"family": "Hergens", "given": "Maria-Pia", "initials": "MP"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "Haglund", "given": "Per", "initials": "P"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Lampa", "given": "Erik", "initials": "E"}, {"family": "Nederby-\u00d6hd", "given": "Joanna", "initials": "J"}, {"family": "\u00d6stlund", "given": "Maria Rotz\u00e9n", "initials": "MR"}, {"family": "Cars", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2022-01-27", "journal": {"title": "Eur J Epidemiol", "issn": "1573-7284", "issn-l": "0393-2990"}, "abstract": "Since the beginning of the Covid-19 pandemic, the scientific community has explored determinants of Covid 19 disease severity. However, the majority of studies are based on in-hospital patients with high risk of collider- or selection bias. The present investigation details risk factors associated with overall mortality, hospitalization and intensive care unit (ICU) admission in Covid-19 infections, with complete population coverage and high-resolution data on patient characteristics and comorbid conditions This population-based observational study comprises all residents 18 years and older in Stockholm Region-1.8 million inhabitants-using the real-time Covid-19 monitoring framework. The observation period lasted between March 1 to December 31, 2020. Hazard ratios (HR) for risk factors of Covid-19 disease severity were assessed using Cox proportional hazard models. In total, 3322 deaths, 11,508 hospitalizations and 1423 ICU-admissions related to Covid-19 occurred during the study period. Kidney failure, diabetes and obesity increased risk of mortality and so did heart failure and ischemic heart disease. However, atrial fibrillation and hypertension did not. Risk of hospitalization follow a similar pattern, whereas admission to intensive care differs; triage processes where clearly present as certain co-morbid conditions were associated with lower ICU admission. Observed differences in risk of mortality and hospitalization among patients with Covid 19 raise important questions about potentially protective comedication which will be further addressed using the real-time Covid-19 monitoring framework.", "doi": "10.1007/s10654-021-00840-7", "pmid": "35083602", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10654-021-00840-7"}, {"db": "pmc", "key": "PMC8791671"}], "notes": [], "created": "2022-01-31T11:48:07.605Z", "modified": "2022-01-31T11:48:07.617Z"}, {"entity": "publication", "iuid": "983a90975b164a94803529dc4a7b9691", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/983a90975b164a94803529dc4a7b9691.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/983a90975b164a94803529dc4a7b9691"}}, "title": "Humoral immunogenicity and tolerability of heterologous ChAd/BNT compared with homologous BNT/BNT and ChAd/ChAd SARS-CoV-2 vaccination in hemodialysis patients : A multicenter prospective observational study.", "authors": [{"family": "Haase", "given": "Michael", "initials": "M", "orcid": "0000-0001-8212-7416", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3d5795641ee4ff0ab46f79603ba5e73.json"}}, {"family": "Lesny", "given": "Paul", "initials": "P", "orcid": "0000-0003-3001-5257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fd70d53d0644bbca442128b4bbdd676.json"}}, {"family": "Anderson", "given": "Mark", "initials": "M"}, {"family": "Cloherty", "given": "Gavin", "initials": "G"}, {"family": "Stec", "given": "Michael", "initials": "M"}, {"family": "Haase-Fielitz", "given": "Anja", "initials": "A", "orcid": "0000-0001-6881-2249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/281cb6db938041329bca7a38c27e39cd.json"}}, {"family": "Haarhaus", "given": "Mathias", "initials": "M", "orcid": "0000-0001-8274-6356", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b32fbbc042844a8a43fa0ab3dda8557.json"}}, {"family": "Santos-Ara\u00fajo", "given": "Carla", "initials": "C"}, {"family": "Veiga", "given": "Pedro Mota", "initials": "PM"}, {"family": "Macario", "given": "Fernando", "initials": "F"}], "type": "journal article", "published": "2022-01-27", "journal": {"title": "J Nephrol", "issn": "1724-6059", "issn-l": null}, "abstract": "After the reports of severe adverse reactions to the AstraZeneca ChAdOx1-S-nCoV-19 vaccine, patients who had received one dose of ChAdOx1-S-nCoV-19 vaccine were recommended a second dose of Pfizer's BNT162b2 vaccine. In hemodialysis patients, we compared the humoral immunogenicity and tolerability of homologous vaccination with ChAdOx1-nCoV-19/ChAdOx1-nCoV-19 (ChAd/ChAd) and BNT162b2/BNT162b2 (BNT/BNT) with heterologous vaccination of first dose of ChAdOx1-nCoV-19 and a second dose with BNT162b2 (ChAd/BNT).\n\nIn a multicenter prospective observational study, SARS-CoV-2 spike-IgG antibody levels, Nucleocapsid-protein-IgG-antibodies, and vaccine tolerability were assessed 6 weeks after second SARS-CoV-2 vaccination in 137 hemodialysis patients and 24 immunocompetent medical personnel.\n\nIn COVID-19-na\u00efve hemodialysis patients, significantly higher median SARS-CoV-2-spike IgG levels were found after ChAd/BNT (N = 16) compared to BNT/BNT (N = 100) or ChAd/ChAd (N = 10) (1744 [25th-75th percentile 276-2840] BAU/mL versus 361 [25th-75th percentile 120-936] BAU/mL; p = 0.009; 1744 [25th-75th percentile 276-2840] BAU/mL versus 100 [25th-75th percentile 41-346] BAU/mL; p = 0.017, respectively). Vaccinated, COVID-19-na\u00efve medical personnel had median SARS-CoV-2 spike-IgG levels of 650 (25th-75th percentile 217-1402) BAU/mL and vaccinated hemodialysis patients with prior COVID-19 7047 (25th-75th percentile 685-10,794) BAU/mL (N = 11). In multivariable regression analysis, heterologous vaccination (ChAd/BNT) of COVID-19-na\u00efve hemodialysis patients was independently associated with SARS-CoV-2 spike-IgG levels. The first dose of ChAd and the second dose of BNT after the first vaccination with ChAd (heterologous vaccination, ChAd/BNT) were associated with more frequent but manageable side effects compared with homologous BNT.\n\nWithin the limitations of this study, heterologous vaccination with ChAd/BNT appears to induce stronger humoral immunity and more frequent but manageable side effects than homologous vaccination with BNT/BNT or with ChAd/ChAd in COVID-19-na\u00efve hemodialysis patients.", "doi": "10.1007/s40620-022-01247-7", "pmid": "35084719", "labels": {"Category: Health": null, "Category: Other": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40620-022-01247-7"}, {"db": "pmc", "key": "PMC8792133"}], "notes": [], "created": "2022-01-31T11:45:33.489Z", "modified": "2022-01-31T11:45:33.628Z"}, {"entity": "publication", "iuid": "0524427e04e14e1396474c73d00bf50d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0524427e04e14e1396474c73d00bf50d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0524427e04e14e1396474c73d00bf50d"}}, "title": "National identity predicts public health support during a global pandemic.", "authors": [{"family": "Van Bavel", "given": "Jay J", "initials": "JJ", "orcid": "0000-0002-2520-0442", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/344fbd5da7bc4259b3f70839f401c84c.json"}}, {"family": "Cichocka", "given": "Aleksandra", "initials": "A", "orcid": "0000-0003-1703-1586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0cc1202c8fb34d07952c7d99ab43bf87.json"}}, {"family": "Capraro", "given": "Valerio", "initials": "V"}, {"family": "Sj\u00e5stad", "given": "Hallgeir", "initials": "H", "orcid": "0000-0002-8730-1038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9d4b3d4379f4e3bb43607c0ef08f159.json"}}, {"family": "Nezlek", "given": "John B", "initials": "JB", "orcid": "0000-0003-4963-3637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab0b925a3d5b4c3d9f03d141757d41ba.json"}}, {"family": "Pavlovi\u0107", "given": "Tomislav", "initials": "T", "orcid": "0000-0002-4470-3715", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b5a5d7b53914f58ba60821e70539887.json"}}, {"family": "Alfano", "given": "Mark", "initials": "M", "orcid": "0000-0001-5879-8033", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9adf19b051647d19c86bc89ee440988.json"}}, {"family": "Gelfand", "given": "Michele J", "initials": "MJ"}, {"family": "Azevedo", "given": "Flavio", "initials": "F", "orcid": "0000-0001-9000-8513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7864cb0e9bf846d6b69a6a5bf65cbd91.json"}}, {"family": "Birtel", "given": "Mich\u00e8le D", "initials": "MD"}, {"family": "Cislak", "given": "Aleksandra", "initials": "A", "orcid": "0000-0002-9880-6947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37e0b6640a76467890fed6a7975b031c.json"}}, {"family": "Lockwood", "given": "Patricia L", "initials": "PL", "orcid": "0000-0001-7195-9559", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d77d4779b0ff456b906f2001dc3aa36f.json"}}, {"family": "Ross", "given": "Robert Malcolm", "initials": "RM", "orcid": "0000-0001-8711-1675", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49cb2e4d713844729ee7d64213f3cdbe.json"}}, {"family": "Abts", "given": "Koen", "initials": "K", "orcid": "0000-0001-8546-8347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9128fa7c6104fecabd5e4e52b1ce6ee.json"}}, {"family": "Agadullina", "given": "Elena", "initials": "E", "orcid": "0000-0002-1505-1412", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1d55ff13a5b4373abb3aca1376a41b9.json"}}, {"family": "Aruta", "given": "John Jamir Benzon", "initials": "JJB", "orcid": "0000-0003-4155-1063", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc1b14a0e89b4d9cb7f9c977e34a9a67.json"}}, {"family": "Besharati", "given": "Sahba Nomvula", "initials": "SN", "orcid": "0000-0003-2836-7982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8948fcda91f444f89cc8ddcfe4e489d9.json"}}, {"family": "Bor", "given": "Alexander", "initials": "A", "orcid": "0000-0002-2624-9221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/048bdb252beb4b2599b619f41ace6277.json"}}, {"family": "Choma", "given": "Becky L", "initials": "BL"}, {"family": "Crabtree", "given": "Charles David", "initials": "CD", "orcid": "0000-0001-5144-8671", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4437f3c146f4f649e796f32d01d6052.json"}}, {"family": "Cunningham", "given": "William A", "initials": "WA"}, {"family": "De", "given": "Koustav", "initials": "K", "orcid": "0000-0001-9562-0672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d6627eccf1d42baa44ed1ab89430f41.json"}}, {"family": "Ejaz", "given": "Waqas", "initials": "W", "orcid": "0000-0002-2492-4115", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0540fea51e3740068aa543e3e9bfd57e.json"}}, {"family": "Elbaek", "given": "Christian T", "initials": "CT", "orcid": "0000-0002-7039-4565", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a44f489ddccb4a208ec453424a471bfc.json"}}, {"family": "Findor", "given": "Andrej", "initials": "A", "orcid": 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{"family": "Vieira", "given": "Joana B", "initials": "JB"}, {"family": "von Sikorski", "given": "Christian", "initials": "C", "orcid": "0000-0002-3787-8277", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bacd3f29f5ff4a93a75fa018974f0d49.json"}}, {"family": "Walker", "given": "Alexander Cameron", "initials": "AC", "orcid": "0000-0003-1431-6770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e48ea603420489e9ad84494d2266981.json"}}, {"family": "Watermeyer", "given": "Jennifer", "initials": "J", "orcid": "0000-0001-7918-8832", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/361039a0f7cb4ad1ba265ac819f61df3.json"}}, {"family": "Wetter", "given": "Erik", "initials": "E"}, {"family": "Whillans", "given": "Ashley", "initials": "A", "orcid": "0000-0002-1726-6978", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/23afeb4b16404c9fbbb5aec95295e358.json"}}, {"family": "Willardt", "given": "Robin", "initials": "R", "orcid": "0000-0002-2495-3450", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5379e789ed5f4144a062b66ca92e60b7.json"}}, {"family": "Wohl", "given": "Michael J A", "initials": "MJA", "orcid": "0000-0001-6945-5562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/669ce114edff4deca4595eac19f30eda.json"}}, {"family": "W\u00f3jcik", "given": "Adrian Dominik", "initials": "AD", "orcid": "0000-0002-7073-6019", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b96aa00cd81f466599febb11c10a3a99.json"}}, {"family": "Wu", "given": "Kaidi", "initials": "K", "orcid": "0000-0001-6881-7437", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab83e58b6bcb415ea5079ac48c77dd7b.json"}}, {"family": "Yamada", "given": "Yuki", "initials": "Y", "orcid": "0000-0003-1431-568X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12d5285132e14b7bbca2607a084fb449.json"}}, {"family": "Yilmaz", "given": "Onurcan", "initials": "O", "orcid": "0000-0002-6094-7162", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/534f37d570044b1f885ebc4c7e9bab54.json"}}, {"family": "Yogeeswaran", "given": "Kumar", "initials": "K"}, {"family": "Ziemer", "given": "Carolin-Theresa", "initials": "CT", "orcid": "0000-0002-0794-7702", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8177b1e630c54506b665af61a4204f3c.json"}}, {"family": "Zwaan", "given": "Rolf A", "initials": "RA"}, {"family": "Boggio", "given": "Paulo S", "initials": "PS"}], "type": "journal article", "published": "2022-01-26", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "517", "issn-l": "2041-1723"}, "abstract": "Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N = 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r = -0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics.", "doi": "10.1038/s41467-021-27668-9", "pmid": "35082277", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-27668-9"}], "notes": [], "created": "2022-01-31T11:49:07.063Z", "modified": "2022-01-31T11:49:27.807Z"}, {"entity": "publication", "iuid": "c02cba320d9d41c1b0f2f13d26ac7fc9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c02cba320d9d41c1b0f2f13d26ac7fc9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c02cba320d9d41c1b0f2f13d26ac7fc9"}}, "title": "Investigating the current environmental situation in the Middle East and North Africa (MENA) region during the third wave of COVID-19 pandemic: urban vs. rural context.", "authors": [{"family": "Abouzid", "given": "Mohamed", "initials": "M"}, {"family": "El-Sherif", "given": "Dina M", "initials": "DM"}, {"family": "Al Naggar", "given": "Yahya", "initials": "Y"}, {"family": "Alshehri", "given": "Mohammed M", "initials": "MM"}, {"family": "Alothman", "given": "Shaima", "initials": "S"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}, {"family": "Trabelsi", "given": "Rayhana", "initials": "R"}, {"family": "Ibrahim", "given": "Osama Mohamed", "initials": "OM"}, {"family": "Temraz", "given": "Esraa Hamouda", "initials": "EH"}, {"family": "Buimsaedah", "given": "Ahmad", "initials": "A"}, {"family": "Aziz", "given": "Ibrahim Adel", "initials": "IA"}, {"family": "Alwan", "given": "Muhammad", "initials": "M"}, {"family": "Al Hasan", "given": "Nuha Hadi Jasim", "initials": "NHJ"}, {"family": "Ragab", "given": "Heba Nasser", "initials": "HN"}, {"family": "Koraiem", "given": "Abdullah Muhammed", "initials": "AM"}, {"family": "Ahmed", "given": "Mareb H", "initials": "MH"}, {"family": "Temraz", "given": "Heba Hamouda", "initials": "HH"}, {"family": "Madeeh", "given": "Alyaa Khaled", "initials": "AK"}, {"family": "Alshareif", "given": "Mohanned Osama", "initials": "MO"}, {"family": "Elkhafeefi", "given": "Fatimah Saad", "initials": "FS"}, {"family": "Badis", "given": "Imed-Eddine", "initials": "IE"}, {"family": "Abdelslam", "given": "Asmaa E", "initials": "AE"}, {"family": "Ali", "given": "Almajdoub Ali Mohammed", "initials": "AAM"}, {"family": "Kotni", "given": "Nour El Imene", "initials": "NEI"}, {"family": "Amer", "given": "Thuraya", "initials": "T"}], "type": "journal article", "published": "2022-01-26", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "177", "issn-l": null}, "abstract": "Coronavirus 2019 (COVID-19) pandemic led to a massive global socio-economic tragedy that has impacted the ecosystem. This paper aims to contextualize urban and rural environmental situations during the COVID-19 pandemic in the Middle East and North Africa (MENA) Region.\n\nAn online survey was conducted, 6770 participants were included in the final analysis, and 64% were females. The majority of the participants were urban citizens (74%). Over 50% of the urban residents significantly (p < 0.001) reported a reduction in noise, gathering in tourist areas, and gathering in malls and restaurants. Concerning the pollutants, most urban and rural areas have reported an increase in masks thrown in streets (69.49% vs. 73.22%, resp.; p = 0.003). Plastic bags and hospital waste also increased significantly with the same p-value of < 0.001 in urban areas compared with rural ones. The multifactorial logistic model for urban resident predictors achieved acceptable discrimination (AUROC = 0.633) according to age, crowdedness, noise and few pollutants.\n\nThe COVID-19 pandemic had a beneficial impact on the environment and at the same time, various challenges regarding plastic and medical wastes are rising which requires environmental interventions.", "doi": "10.1186/s12889-021-12313-3", "pmid": "35081927", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-12313-3"}, {"db": "pmc", "key": "PMC8790551"}], "notes": [], "created": "2022-01-31T11:49:45.217Z", "modified": "2022-01-31T11:49:45.246Z"}, {"entity": "publication", "iuid": "dd12a80548b54077976f107f7b65cf6d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dd12a80548b54077976f107f7b65cf6d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dd12a80548b54077976f107f7b65cf6d"}}, "title": "Computational Analysis Reveals Monomethylated Triazolopyrimidine as a Novel Inhibitor of SARS-CoV-2 RNA-Dependent RNA Polymerase (RdRp).", "authors": [{"family": "Karthic", "given": "Anandakrishnan", "initials": "A"}, {"family": "Kesarwani", "given": "Veerbhan", "initials": "V", "orcid": "0000-0001-5778-6831", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c0f527583f94625bb9d2106104fb7d2.json"}}, {"family": "Singh", "given": "Rahul Kunwar", "initials": "RK", "orcid": "0000-0003-3630-5706", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02f5d3fe155541d1b88e8c90ba420ab3.json"}}, {"family": "Yadav", "given": "Pavan Kumar", "initials": "PK"}, {"family": "Chaturvedi", "given": "Navaneet", "initials": "N", "orcid": "0000-0002-4265-9255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b6f5bf7d4ff4477b7e35faac4df684c.json"}}, {"family": "Chauhan", "given": "Pallavi", "initials": "P", "orcid": "0000-0002-5160-6673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6f59a01303e4493393dbe2fba6b2e8f7.json"}}, {"family": "Yadav", "given": "Brijesh Singh", "initials": "BS"}, {"family": "Kushwaha", "given": "Sandeep Kumar", "initials": "SK"}], "type": "journal article", "published": "2022-01-26", "journal": {"title": "Molecules", "issn": "1420-3049", "volume": "27", "issue": "3", "issn-l": null}, "abstract": "The human population is still facing appalling conditions due to several outbreaks of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus. The absence of specific drugs, appropriate vaccines for mutants, and knowledge of potential therapeutic agents makes this situation more difficult. Several 1, 2, 4-triazolo [1, 5-a] pyrimidine (TP)-derivative compounds were comprehensively studied for antiviral activities against RNA polymerase of HIV, HCV, and influenza viruses, and showed immense pharmacological interest. Therefore, TP-derivative compounds can be repurposed against the RNA-dependent RNA polymerase (RdRp) protein of SARS-CoV-2. In this study, a meta-analysis was performed to ensure the genomic variability and stability of the SARS-CoV-2 RdRp protein. The molecular docking of natural and synthetic TP compounds to RdRp and molecular dynamic (MD) simulations were performed to analyse the dynamic behaviour of TP compounds at the active site of the RdRp protein. TP compounds were also docked against other non-structural proteins (NSP1, NSP2, NSP3, NSP5, NSP8, NSP13, and NSP15) of SARS-CoV-2. Furthermore, the inhibition potential of TP compounds was compared with Remdesivir and Favipiravir drugs as a positive control. Additionally, TP compounds were analysed for inhibitory activity against SARS-CoV RdRp protein. This study demonstrates that TP analogues (monomethylated triazolopyrimidine and essramycin) represent potential lead molecules for designing an effective inhibitor to control viral replication. Furthermore, in vitro and in vivo studies will strengthen the use of these inhibitors as suitable drug candidates against SARS-CoV-2.", "doi": "10.3390/molecules27030801", "pmid": "35164069", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "molecules27030801"}], "notes": [], "created": "2022-02-17T06:08:36.632Z", "modified": "2022-02-17T06:09:00.719Z"}, {"entity": "publication", "iuid": "cf59a3c7e7c34226b242a79239cb1c2b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cf59a3c7e7c34226b242a79239cb1c2b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cf59a3c7e7c34226b242a79239cb1c2b"}}, "title": "Living conditions, lifestyle habits and health among adults before and after the COVID-19 pandemic outbreak in Sweden - results from a cross-sectional population-based study.", "authors": [{"family": "Molarius", "given": "Anu", "initials": "A"}, {"family": "Persson", "given": "Carina", "initials": "C"}], "type": "journal article", "published": "2022-01-25", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "171", "issn-l": null}, "abstract": "Studies on the public health consequences of COVID-19 pandemic showing data based on robust methods are scarce. The aim of this study was to investigate mental and physical health as well as living conditions and lifestyle habits in the general population before and after the COVID-19 outbreak in Sweden.\n\nThe study is based on 2273 persons 16-84 years who responded to the national public health survey in February-May 2020 in V\u00e4rmland county (overall response rate 45%). The differences between early respondents (before the outbreak, n = 1711) and late respondents (after the outbreak, n = 562) were studied using multivariate logistic regression, adjusting for background characteristics: age, gender, educational level, and country of birth. The same analyses were also completed in the corresponding survey carried out in February-June 2018.\n\nStatistically significant differences between the groups were obtained for economic difficulties and worry about losing one's job, which were more common among late respondents, and for sleeping difficulties, which were more common among early respondents after adjusting for background characteristics. There were no differences in other living conditions nor in lifestyle factors. Prevalence of good self-rated health, high blood pressure, aches in shoulders or neck, anxiety or worry and stress did not differ between the groups. In 2018, the only statistically significant difference between early and late respondents concerned economic difficulties.\n\nVery few differences in living conditions, lifestyle factors and health were observed in the study population before and after the COVID-19 outbreak. The results suggest that, in addition to a possible decrease in sleeping difficulties, the prevalence of being worried about losing one's job increased among the employed after the outbreak.", "doi": "10.1186/s12889-021-12315-1", "pmid": "35078430", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-12315-1"}, {"db": "pmc", "key": "PMC8787439"}], "notes": [], "created": "2022-01-27T06:59:44.489Z", "modified": "2022-01-31T11:50:19.633Z"}, {"entity": "publication", "iuid": "84fdbc5f70264da68f79b41a55046bae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84fdbc5f70264da68f79b41a55046bae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84fdbc5f70264da68f79b41a55046bae"}}, "title": "Effectiveness of tobacco cessation interventions for different groups of tobacco users in Sweden: a study protocol for a national prospective cohort study.", "authors": [{"family": "Rasmussen", "given": "Mette", "initials": "M", "orcid": "0000-0003-2847-1544", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/155367945a2f4bb186320d69eea6a117.json"}}, {"family": "Larsson", "given": "Matz", "initials": "M"}, {"family": "Gilljam", "given": "Hans", "initials": "H"}, {"family": "Adami", "given": "Johanna", "initials": "J"}, {"family": "W\u00e4rjerstam", "given": "Sanne", "initials": "S"}, {"family": "Post", "given": "Ann", "initials": "A"}, {"family": "Bj\u00f6rk-Eriksson", "given": "Thomas", "initials": "T"}, {"family": "Helgason", "given": "Asgeir R", "initials": "AR"}, {"family": "T\u00f8nnesen", "given": "Hanne", "initials": "H"}], "type": "journal article", "published": "2022-01-25", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "1", "pages": "e053090", "issn-l": "2044-6055"}, "abstract": "Tobacco is still one of the single most important risk factors among the lifestyle habits that cause morbidity and mortality in humans. Furthermore, tobacco has a heavy social gradient, as the consequences are even worse among disadvantaged and vulnerable groups. To reduce tobacco-related inequity in health, those most in need should be offered the most effective tobacco cessation intervention. The aim of this study is to facilitate and improve the evaluation of already implemented national tobacco cessation efforts, focusing on 10 disadvantaged and vulnerable groups of tobacco users.\n\nThis is a prospective cohort study. Data will be collected by established tobacco cessation counsellors in Sweden. The study includes adult tobacco or e-cigarette users, including disadvantaged and vulnerable patients, receiving in-person interventions for tobacco or e-cigarette cessation (smoking, snus and/or e-cigarettes). Patient inclusion was initiated in April 2020. For data analyses patients will be sorted into vulnerable groups based on risk factors and compared with tobacco users without the risk factor in question.The primary outcome is continuous successful quitting after 6 months, measured by self-reporting. Secondary outcomes include abstinence at the end of the treatment programme, which could be from minutes over days to weeks, 14-day point prevalence after 6 months, and patient satisfaction with the intervention. Effectiveness of successful quitting will be examined by comparing vulnerable with non-vulnerable patients using a mixed-effect logistic regression model adjusting for potential prognostic factors and known confounders.\n\nThe project will follow the guidelines from the Swedish Data Protection Authority and have been approved by the Swedish Ethical Review Authority before patient inclusion (Dnr: 2019-02221). Only patients providing written informed consent will be included. Both positive and negative results will be published in scientific peer-reviewed journals and presented at national and international conferences. Information will be provided through media available to the public, politicians, healthcare providers and planners as these are all important stakeholders.\n\nNCT04819152.", "doi": "10.1136/bmjopen-2021-053090", "pmid": "35078840", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-053090"}, {"db": "ClinicalTrials.gov", "key": "NCT04819152"}], "notes": [], "created": "2022-01-27T06:59:16.941Z", "modified": "2022-01-31T11:50:05.070Z"}, {"entity": "publication", "iuid": "b6b72a9a8e9f447b858546ce4f87518e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b6b72a9a8e9f447b858546ce4f87518e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b6b72a9a8e9f447b858546ce4f87518e"}}, "title": "Correction for Rando et al., \"Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure\".", "authors": [{"family": "Rando", "given": "Halie M", "initials": "HM", "orcid": "0000-0001-7688-1770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b5a9f4ec1bd48579abca9895dab3ea7.json"}}, {"family": "MacLean", "given": "Adam L", "initials": "AL", "orcid": "0000-0003-0689-7907", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c26b86f5b6704c6bb26549e40cb2a1a6.json"}}, {"family": "Lee", "given": "Alexandra J", "initials": "AJ", "orcid": "0000-0002-0208-3730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/761782ce14b542078b3ee6c0db2bb6ce.json"}}, {"family": "Lordan", "given": "Ronan", "initials": "R", "orcid": "0000-0001-9668-3368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0126a49dfcdf49fcb53041fbdcd91706.json"}}, {"family": "Ray", "given": "Sandipan", "initials": "S", "orcid": "0000-0002-9960-5768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa10e3ee0fd54ba493cbe4cca8fc6eff.json"}}, {"family": "Bansal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-0944-7226", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae5fbe58965d4d2ca9051acb7d654def.json"}}, {"family": "Skelly", "given": "Ashwin N", "initials": "AN", "orcid": "0000-0002-1565-3376", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9818ecec2a65431faf931d73ea71bcb2.json"}}, {"family": "Sell", "given": "Elizabeth", "initials": "E", "orcid": "0000-0002-9658-1107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8da837618164c6e95e39ec75771917c.json"}}, {"family": "Dziak", "given": "John J", "initials": "JJ", "orcid": "0000-0003-0762-5495", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7cab03612a54c61b5f336726df5fd86.json"}}, {"family": "Shinholster", "given": "Lamonica", "initials": "L", "orcid": "0000-0001-6285-005X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/55c5da8c3c764c3fbc5877f15931f19b.json"}}, {"family": "D'Agostino McGowan", "given": "Lucy", "initials": "L", "orcid": "0000-0001-7297-9359", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eaf0882d7094646bd20be91a897cf8f.json"}}, {"family": "Ben Guebila", "given": "Marouen", "initials": "M", "orcid": "0000-0001-5934-966X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e04fc9008f7f4307a76515f913f19adf.json"}}, {"family": "Wellhausen", "given": "Nils", "initials": "N", "orcid": "0000-0001-8955-7582", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/934767f0228241648d70c7b00527deff.json"}}, {"family": "Knyazev", "given": "Sergey", "initials": "S", "orcid": "0000-0003-0385-1831", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5191e5ac40f244369f156171f69b6043.json"}}, {"family": "Boca", "given": "Simina M", "initials": "SM", "orcid": "0000-0002-1400-3398", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3eb0ffeffea24d5cb745b5ca86648e60.json"}}, {"family": "Capone", "given": "Stephen", "initials": "S", "orcid": "0000-0001-7231-1535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e5465fb84654d2d8edc152bc1fabb0a.json"}}, {"family": "Qi", "given": "Yanjun", "initials": "Y", "orcid": "0000-0002-5796-7453", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d48badb4eff4f4f9bf3f15632f0c3a7.json"}}, {"family": "Park", "given": "YoSon", "initials": "Y", "orcid": "0000-0002-0465-4744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d3c095fe591449a8c122645bf540ed5.json"}}, {"family": "Mai", "given": "David", "initials": "D", "orcid": "0000-0002-9238-0164", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c9a0a9f7fd0402b889577876833cb01.json"}}, {"family": "Sun", "given": "Yuchen", "initials": "Y"}, {"family": "Boerckel", "given": "Joel D", "initials": "JD", "orcid": "0000-0003-3126-3025", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c5b796936cf42d7a3ea63f54266f680.json"}}, {"family": "Brueffer", "given": "Christian", "initials": "C", "orcid": "0000-0002-3826-0989", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c4f95c1889f4f098676404aec6125ca.json"}}, {"family": "Byrd", "given": "James Brian", "initials": "JB", "orcid": "0000-0002-0509-3520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bc319c5d0d74676875bd9ff266f5e80.json"}}, {"family": "Kamil", "given": "Jeremy P", "initials": "JP", "orcid": "0000-0001-8422-7656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa225803435a4d7b803176e2ccfbef19.json"}}, {"family": "Wang", "given": "Jinhui", "initials": "J", "orcid": "0000-0002-5796-8130", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5243fdc11744ba89697e8fdf9c2feee.json"}}, {"family": "Velazquez", "given": "Ryan", "initials": "R", "orcid": "0000-0002-3655-3403", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32443d060ec043e59e1683db8be8a2f0.json"}}, {"family": "Szeto", "given": "Gregory L", "initials": "GL", "orcid": "0000-0001-7604-1333", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ca2a47e8bce54293918ec2bec05b0cd0.json"}}, {"family": "Barton", "given": "John P", "initials": "JP", "orcid": "0000-0003-1467-421X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae8b1b4348b5476fa268c2079c6b9c7d.json"}}, {"family": "Goel", "given": "Rishi Raj", "initials": "RR", "orcid": "0000-0003-1715-5191", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ad2f4cb84774051bb9422f314ec0f11.json"}}, {"family": "Mangul", "given": "Serghei", "initials": "S", "orcid": "0000-0003-4770-3443", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dbe15e382e84d38a0fd859377e39d47.json"}}, {"family": "Lubiana", "given": "Tiago", "initials": "T", "orcid": "0000-0003-2473-2313", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/132869d486e241dda1448ef1448ab83c.json"}}, {"family": "COVID-19 Review Consortium", "given": "", "initials": ""}, {"family": "Gitter", "given": "Anthony", "initials": "A", "orcid": "0000-0002-5324-9833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7085c8743e3442859ad6f23198c85456.json"}}, {"family": "Greene", "given": "Casey S", "initials": "CS", "orcid": "0000-0001-8713-9213", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42aaaac8b65642538f28f9cd2045ab8d.json"}}], "type": "journal article", "published": "2022-01-25", "journal": {"title": "mSystems", "issn": "2379-5077", "pages": "e0144721", "issn-l": null}, "abstract": null, "doi": "10.1128/msystems.01447-21", "pmid": "35076276", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2022-01-26T08:23:59.651Z", "modified": "2022-01-26T08:24:00.210Z"}, {"entity": "publication", "iuid": "bafbb26351e0441bafd8aa7de38cd297", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bafbb26351e0441bafd8aa7de38cd297.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bafbb26351e0441bafd8aa7de38cd297"}}, "title": "A patient satisfaction survey and educational package to improve the care of people hospitalised with COVID-19: a quality improvement project, Liverpool, UK.", "authors": [{"family": "Ahmad", "given": "Muhammad Shamsher", "initials": "MS"}, {"family": "Hicks", "given": "Scott Rory", "initials": "SR"}, {"family": "Watson", "given": "Rebecca", "initials": "R"}, {"family": "Ahmed", "given": "Rajia Akter", "initials": "RA"}, {"family": "Jones", "given": "Lewis", "initials": "L"}, {"family": "Vaselli", "given": "Marcella", "initials": "M"}, {"family": "Wu", "given": "Meng-San", "initials": "MS"}, {"family": "Hayat", "given": "Fatima", "initials": "F"}, {"family": "Ratcliffe", "given": "Libuse", "initials": "L"}, {"family": "McKenna", "given": "Mark", "initials": "M"}, {"family": "Hine", "given": "Paul", "initials": "P"}, {"family": "Defres", "given": "Sylviane", "initials": "S"}, {"family": "Wingfield", "given": "Tom", "initials": "T"}], "type": "journal article", "published": "2022-01-25", "journal": {"title": "Wellcome Open Res", "issn": "2398-502X", "volume": "6", "pages": "222", "issn-l": null}, "abstract": "Background: The perspectives and experiences of people hospitalised with COVID-19 have been under-reported during the coronavirus pandemic. We developed and conducted a COVID-19 patient satisfaction survey in a large university-affiliated secondary healthcare centre in Liverpool, UK, during Europe's first coronavirus wave (April-June 2020). The survey found that care was rated highly, including among people of Black Asian and Minority Ethnic (BAME) backgrounds. However, sleep-quality and communication about medications and discharge-planning were identified as areas for improvement. Methods: To improve care for people with COVID-19 admitted to our centre, we designed an educational package for healthcare professionals working on COVID-19 wards. The package, implemented in August 2020, included healthcare worker training sessions on providing holistic care and placement of \"Practice Pointers\" posters. Patient satisfaction was re-evaluated during the second/third COVID-19 waves in Liverpool (September 2020 - February 2021). Results: Across waves, most (95%) respondents reported that they would recommend our hospital to friends and/or family and rated overall care highly. Comparison of the responses of second/third-wave respondents (n=101) with first-wave respondents (n=94) suggested improved patient satisfaction across most care domains but especially those related to having worries and fears addressed and being consulted about medications and their side-effects. Conclusions: People admitted with COVID-19 to our centre in Liverpool, including those from BAME backgrounds, rated the care they received highly. A simple education package improved the feedback on care received by respondents between the first and second/third waves. These UK-first findings are informing regional strategies to improve person-centred care of hospitalised people with COVID-19.", "doi": "10.12688/wellcomeopenres.17163.2", "pmid": "35118199", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8787571.2"}], "notes": [], "created": "2022-02-06T16:46:17.605Z", "modified": "2022-02-08T15:17:21.605Z"}, {"entity": "publication", "iuid": "4b540bc2f54746448d5bdbf914ca7561", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b540bc2f54746448d5bdbf914ca7561.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b540bc2f54746448d5bdbf914ca7561"}}, "title": "The importance of accessory protein variants in the pathogenicity of SARS-CoV-2.", "authors": [{"family": "Hassan", "given": "Sk Sarif", "initials": "SS"}, {"family": "Choudhury", "given": "Pabitra Pal", "initials": "PP"}, {"family": "Dayhoff", "given": "Guy W", "initials": "GW"}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA"}, {"family": "Uhal", "given": "Bruce D", "initials": "BD"}, {"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Pizzol", "given": "Damiano", "initials": "D"}, {"family": "Adadi", "given": "Parise", "initials": "P"}, {"family": "Lal", "given": "Amos", "initials": "A"}, {"family": "Soares", "given": "Antonio", "initials": "A"}, {"family": "Mohamed Abd El-Aziz", "given": "Tarek", "initials": "T"}, {"family": "Brufsky", "given": "Adam M", "initials": "AM"}, {"family": "Azad", "given": "Gajendra Kumar", "initials": "GK"}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Baetas-da-Cruz", "given": "Wagner", "initials": "W"}, {"family": "Takayama", "given": "Kazuo", "initials": "K"}, {"family": "Serrano-Aroca", "given": "\u00c3ngel", "initials": "\u00c3"}, {"family": "Chauhan", "given": "Gaurav", "initials": "G"}, {"family": "Palu", "given": "Giorgio", "initials": "G"}, {"family": "Mishra", "given": "Yogendra Kumar", "initials": "YK"}, {"family": "Barh", "given": "Debmalya", "initials": "D"}, {"family": "Santana Silva", "given": "Raner Jo\u015be", "initials": "RJ"}, {"family": "Andrade", "given": "Bruno Silva", "initials": "BS"}, {"family": "Azevedo", "given": "Vasco", "initials": "V"}, {"family": "G\u00f3es-Neto", "given": "Arist\u00f3teles", "initials": "A"}, {"family": "Bazan", "given": "Nicolas G", "initials": "NG"}, {"family": "Redwan", "given": "Elrashdy M", "initials": "EM"}, {"family": "Tambuwala", "given": "Murtaza", "initials": "M"}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN"}], "type": "journal article", "published": "2022-01-24", "journal": {"title": "Arch Biochem Biophys", "issn": "1096-0384", "volume": "717", "pages": "109124", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 possess putative functions to manipulate host immune mechanisms. These involve interferons, which appear as a consensus function, immune signaling receptor NLRP3 (NLR family pyrin domain-containing 3) inflammasome, and inflammatory cytokines such as interleukin 1\u03b2 (IL-1\u03b2) and are critical in COVID-19 pathology. Outspread variations of each of the six accessory proteins were observed across six continents of all complete SARS-CoV-2 proteomes based on the data reported before November 2020. A decreasing order of percentage of unique variations in the accessory proteins was determined as ORF3a > ORF8 > ORF7a > ORF6 > ORF10 > ORF7b across all continents. The highest and lowest unique variations of ORF3a were observed in South America and Oceania, respectively. These findings suggest that the wide variations in accessory proteins seem to affect the pathogenicity of SARS-CoV-2.", "doi": "10.1016/j.abb.2022.109124", "pmid": "35085577", "labels": {"Category: Health": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0003-9861(22)00009-1"}, {"db": "pmc", "key": "PMC8785432"}], "notes": [], "created": "2022-01-31T11:45:10.498Z", "modified": "2022-01-31T11:45:10.533Z"}, {"entity": "publication", "iuid": "5f5d5f35bd3b4786b8079a511e0db6fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f5d5f35bd3b4786b8079a511e0db6fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f5d5f35bd3b4786b8079a511e0db6fd"}}, "title": "Large gaps in the quality of healthcare experienced by Swedish mothers during the COVID-19 pandemic: A cross-sectional study based on WHO standards.", "authors": [{"family": "Zaigham", "given": "Mehreen", "initials": "M"}, {"family": "Linden", "given": "Karolina", "initials": "K"}, {"family": "Sengpiel", "given": "Verena", "initials": "V"}, {"family": "Mariani", "given": "Ilaria", "initials": "I"}, {"family": "Valente", "given": "Emanuelle Pessa", "initials": "EP"}, {"family": "Covi", "given": "Benedetta", "initials": "B"}, {"family": "Lazzerini", "given": "Marzia", "initials": "M"}, {"family": "Elden", "given": "Helen", "initials": "H"}, {"family": "IMAgiNE EURO Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-01-24", "journal": {"title": "Women Birth", "issn": "1878-1799", "issn-l": null}, "abstract": "Existing healthcare systems have been put under immense pressure during the COVID-19 pandemic. Disruptions in essential maternal and newborn services have come from even high-income countries within the World Health Organization (WHO) European Region.\n\nTo describe the quality of care during pregnancy and childbirth, as reported by the women themselves, during the COVID-19 pandemic in Sweden, using the WHO 'Standards for improving quality of maternal and newborn care in health facilities'.\n\nUsing an anonymous, online questionnaire, women \u226518 years were invited to participate if they had given birth in Sweden from March 1, 2020 to June 30, 2021. The quality of maternal and newborn care was measured using 40 questions across four domains: provision of care, experience of care, availability of human/physical resources, and organisational changes due to COVID-19.\n\nOf the 5003 women included, n = 4528 experienced labour. Of these, 46.7% perceived a poorer quality of maternal and newborn care due to the COVID-19. Fundal pressure was applied in 22.2% of instrumental vaginal births, 36.8% received inadequate breastfeeding support and 6.9% reported some form of abuse. Findings were worse in women undergoing prelabour Caesarean section (CS) (n = 475). Multivariate analysis showed significant associations of the quality of maternal and newborn care to year of birth (P < 0.001), parity (P < 0.001), no pharmacological pain relief (P < 0.001), prelabour CS (P < 0.001), emergency CS (P < 0.001) and overall satisfaction (P < 0.001).\n\nConsiderable gaps over many key quality measures and deviations from women-centred care were noted. Findings were worse in women with prelabour CS. Actions to promote high-quality, evidence-based and respectful care during childbirth for all mothers are urgently needed.", "doi": "10.1016/j.wombi.2022.01.007", "pmid": "35123922", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1871-5192(22)00010-5"}], "notes": [], "created": "2022-02-08T15:16:44.040Z", "modified": "2022-02-08T15:16:44.074Z"}, {"entity": "publication", "iuid": "6ca32244d0bc40a1b1fe81f99ab27022", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ca32244d0bc40a1b1fe81f99ab27022.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ca32244d0bc40a1b1fe81f99ab27022"}}, "title": "Job satisfaction and challenges of working from home during the COVID-19 pandemic: A study in a Swedish academic setting.", "authors": [{"family": "Zandi", "given": "Saeid", "initials": "S"}, {"family": "Ahmadi", "given": "Fereshteh", "initials": "F"}, {"family": "Cetrez", "given": "\u00d6nver Andreas", "initials": "\u00d6A"}, {"family": "Akhavan", "given": "Sharareh", "initials": "S"}], "type": "journal article", "published": "2022-01-24", "journal": {"title": "Work", "issn": "1875-9270", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic changed the academic world in various ways, and most universities are still closed and continue operating via teleworking.\r\n\r\nThis study is intended to investigate how university faculty/staff and students in Sweden have coped with the lockdown and working/studying from home during the pandemic.\r\n\r\nA survey was conducted among 277 women and men working and studying at different universities in Sweden.\r\n\r\nThe results indicate that most (61%) respondents were very or somewhat satisfied with the current work-from-home arrangement. Additionally, they indicate that, overall, almost 30% were working more than usual due to the pandemic and teleworking. The coping methods having the highest impact on overall job satisfaction were: \"thinking about what I can do rather than what I can't do\"; \"being able to access medical resources and medical services if I need to seek help\"; and \"having trust in state or health authorities in my country.\"\r\n\r\nThe study reveals that Sweden can serve as a good example of how university faculty/staff and students can address the occupational challenges caused by a health pandemic and possible subsequent quarantines.", "doi": "10.3233/WOR-210442", "pmid": "35095001", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "WOR210442"}], "notes": [], "created": "2022-02-06T17:03:51.861Z", "modified": "2022-11-22T05:40:30.241Z"}, {"entity": "publication", "iuid": "a72928556fb247c2bef359ecfeea0219", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a72928556fb247c2bef359ecfeea0219.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a72928556fb247c2bef359ecfeea0219"}}, "title": "Effects of the Early Phase of COVID-19 on the Autistic Community in Sweden: A Qualitative Multi-Informant Study Linking to ICF.", "authors": [{"family": "Fridell", "given": "Anna", "initials": "A"}, {"family": "Norrman", "given": "Hjalmar Nobel", "initials": "HN"}, {"family": "Girke", "given": "Linda", "initials": "L"}, {"family": "B\u00f6lte", "given": "Sven", "initials": "S"}], "type": "journal article", "published": "2022-01-24", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "3", "issn-l": null}, "abstract": "While the COVID-19 pandemic is ongoing, early outcome studies indicate severe and pervasive global effects of the pandemic and associated measures to prevent the spread of the virus. General population studies, as well as insight into the outcomes for particular groups, will be necessary in order to mitigate potentially long-term effects as well as to prepare for future epidemics or pandemics. The pandemic conditions have been marked by rapid and abrupt changes and unpredictability which are circumstances that leave the autistic population particularly vulnerable to adverse outcomes following the distinctive features of the diagnosis. Studies are only beginning to delineate the outcomes of the global autism community and the present study adds to these findings by providing a local, multi-perspective, qualitative analysis of the lived experiences of the Swedish autism community. In this study, autistic youth and adults, caregivers of autistic individuals, as well as representatives of Swedish interest organizations were interviewed. Thematic analysis was performed on the population as a whole and patterns of results were formalized according to the International Classification of Function, Disability and Health (ICF-CY). Participants report wide-ranging adverse outcomes of the pandemic relating to mental health and access to support, participation in daily activities and socialization, education, and work as well as parental resources. However, participants also report positive outcomes relating to a reduction in specific social and everyday demands, and normalization of lived experiences. Additionally, interviews outlined some strategies used to cope during pandemic conditions. Implications of these findings are discussed.", "doi": "10.3390/ijerph19031268", "pmid": "35162290", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph19031268"}], "notes": [], "created": "2022-02-17T06:09:37.469Z", "modified": "2022-02-17T06:09:37.480Z"}, {"entity": "publication", "iuid": "232f63dad3c74e8d88722bbe6132904e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/232f63dad3c74e8d88722bbe6132904e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/232f63dad3c74e8d88722bbe6132904e"}}, "title": "A Model Predicting Mortality of Hospitalized Covid-19 Patients Four Days After Admission: Development, Internal and Temporal-External Validation.", "authors": [{"family": "Heber", "given": "Stefan", "initials": "S"}, {"family": "Pereyra", "given": "David", "initials": "D"}, {"family": "Schrottmaier", "given": "Waltraud C", "initials": "WC"}, {"family": "Kammerer", "given": "Kerstin", "initials": "K"}, {"family": "Santol", "given": "Jonas", "initials": "J"}, {"family": "Rumpf", "given": "Benedikt", "initials": "B"}, {"family": "Pawelka", "given": "Erich", "initials": "E"}, {"family": "Hanna", "given": "Markus", "initials": "M"}, {"family": "Scholz", "given": "Alexander", "initials": "A"}, {"family": "Liu", "given": "Markus", "initials": "M"}, {"family": "Hell", "given": "Agnes", "initials": "A"}, {"family": "Heiplik", "given": "Klara", "initials": "K"}, {"family": "Lickefett", "given": "Benno", "initials": "B"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Traugott", "given": "Marianna T", "initials": "MT"}, {"family": "Neub\u00f6ck", "given": "Matthias J", "initials": "MJ"}, {"family": "Sch\u00f6rgenhofer", "given": "Christian", "initials": "C"}, {"family": "Seitz", "given": "Tamara", "initials": "T"}, {"family": "Firbas", "given": "Christa", "initials": "C"}, {"family": "Karolyi", "given": "Mario", "initials": "M"}, {"family": "Weiss", "given": "G\u00fcnter", "initials": "G"}, {"family": "Jilma", "given": "Bernd", "initials": "B"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Bellmann-Weiler", "given": "Rosa", "initials": "R"}, {"family": "Salzer", "given": "Helmut J F", "initials": "HJF"}, {"family": "Szepannek", "given": "Gero", "initials": "G"}, {"family": "Fischer", "given": "Michael J M", "initials": "MJM"}, {"family": "Zoufaly", "given": "Alexander", "initials": "A"}, {"family": "Gleiss", "given": "Andreas", "initials": "A"}, {"family": "Assinger", "given": "Alice", "initials": "A"}], "type": "journal article", "published": "2022-01-24", "journal": {"title": "Front Cell Infect Microbiol", "issn": "2235-2988", "volume": "11", "pages": "795026", "issn-l": null}, "abstract": "To develop and validate a prognostic model for in-hospital mortality after four days based on age, fever at admission and five haematological parameters routinely measured in hospitalized Covid-19 patients during the first four days after admission.\n\nHaematological parameters measured during the first 4 days after admission were subjected to a linear mixed model to obtain patient-specific intercepts and slopes for each parameter. A prediction model was built using logistic regression with variable selection and shrinkage factor estimation supported by bootstrapping. Model development was based on 481 survivors and 97 non-survivors, hospitalized before the occurrence of mutations. Internal validation was done by 10-fold cross-validation. The model was temporally-externally validated in 299 survivors and 42 non-survivors hospitalized when the Alpha variant (B.1.1.7) was prevalent.\n\nThe final model included age, fever on admission as well as the slope or intercept of lactate dehydrogenase, platelet count, C-reactive protein, and creatinine. Tenfold cross validation resulted in a mean area under the receiver operating characteristic curve (AUROC) of 0.92, a mean calibration slope of 1.0023 and a Brier score of 0.076. At temporal-external validation, application of the previously developed model showed an AUROC of 0.88, a calibration slope of 0.95 and a Brier score of 0.073. Regarding the relative importance of the variables, the (apparent) variation in mortality explained by the six variables deduced from the haematological parameters measured during the first four days is higher (explained variation 0.295) than that of age (0.210).\n\nThe presented model requires only variables routinely acquired in hospitals, which allows immediate and wide-spread use as a decision support for earlier discharge of low-risk patients to reduce the burden on the health care system.\n\nAustrian Coronavirus Adaptive Clinical Trial (ACOVACT); ClinicalTrials.gov, identifier NCT04351724.", "doi": "10.3389/fcimb.2021.795026", "pmid": "35141170", "labels": {"Category: Health": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pmc", "key": "PMC8819729"}, {"db": "ClinicalTrials.gov", "key": "NCT04351724"}], "notes": [], "created": "2022-02-11T10:22:45.318Z", "modified": "2022-02-11T10:23:22.712Z"}, {"entity": "publication", "iuid": "9b7b92f7ea4d4787ad56daa4bc4e4930", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b7b92f7ea4d4787ad56daa4bc4e4930.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b7b92f7ea4d4787ad56daa4bc4e4930"}}, "title": "Predictive performance and clinical application of COV50, a urinary proteomic biomarker in early COVID-19 infection: a cohort study", "authors": [{"family": "Staessen", "given": "Jan A", "initials": "JA"}, {"family": "Wendt", "given": "Ralph", "initials": "R"}, {"family": "Yu", "given": "Yu Ling", "initials": "YL"}, {"family": "Thijs", "given": "Lutgarde", "initials": "L"}, {"family": "Siwy", "given": "Justyna", "initials": "J"}, {"family": "Raad", "given": "Julia", "initials": "J"}, {"family": "Metzger", "given": "Jochen", "initials": "J"}, {"family": "Neuhaus", "given": "Barbara", "initials": "B"}, {"family": "Papkalla", "given": "Armin", "initials": "A"}, {"family": "von der Leyen", "given": "Heiko", "initials": "H"}, {"family": "Mebazaa", "given": "Alexandre", "initials": "A"}, {"family": "Dudoignon", "given": "Emmanual", "initials": "E"}, {"family": "Spasovski", "given": "Goce", "initials": "G"}, {"family": "Milenkova", "given": "Mimoza", "initials": "M"}, {"family": "Canevska-Taneska", "given": "Aleksandra", "initials": "A"}, {"family": "Psichogiou", "given": "Mina", "initials": "M"}, {"family": "Rajzer", "given": "Marke W", "initials": "MW"}, {"family": "Fulawka", "given": "Lukasz", "initials": "L"}, {"family": "Dzitkowska-Zabielska", "given": "Magdalena", "initials": "M"}, {"family": "Weiss", "given": "Guenter", "initials": "G"}, {"family": "Feldt", "given": "Torsten", "initials": "T"}, {"family": "Stegemann", "given": "Miriam", "initials": "M"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Zoufaly", "given": "Alexander", "initials": "A"}, {"family": "Schmiedel", "given": "Stefan", "initials": "S"}, {"family": "Seilmaier", "given": "Michael", "initials": "M"}, {"family": "Rumpf", "given": "Benedikt", "initials": "B"}, {"family": "Banasik", "given": "Miroslaw", "initials": "M"}, {"family": "Krajewska", "given": "Magdalena", "initials": "M"}, {"family": "Catanese", "given": "Lorenzo", "initials": "L"}, {"family": "Rupprecht", "given": "Harald", "initials": "H"}, {"family": "Czerwienska", "given": "Beata", "initials": "B"}, {"family": "Peters", "given": "Bjoern", "initials": "B"}, {"family": "Nilsson", "given": "Asa", "initials": "A"}, {"family": "Rothfuss", "given": "Katja", "initials": "K"}, {"family": "Luebbert", "given": "Christoph", "initials": "C"}, {"family": "Mischak", "given": "Harald", "initials": "H"}, {"family": "Beige", "given": "Joachim", "initials": "J"}], "type": "posted-content", "published": "2022-01-23", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.01.20.22269599", "pmid": null, "labels": {"Category: Health": null, "Type: Preprint": null, "Category: Biochemistry": null, "Category: Omicron VoC": null}, "xrefs": [], "notes": [], "created": "2022-01-24T10:43:58.258Z", "modified": "2022-01-26T16:37:04.903Z"}, {"entity": "publication", "iuid": "d9acb2305e904b518161562e376043a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d9acb2305e904b518161562e376043a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d9acb2305e904b518161562e376043a1"}}, "title": "Pilot application of Lecture-Panel-Discussion Model (LPDM) in global collaborative neurosurgical education: a novel training paradigm innovated by the Swedish African Neurosurgery Collaboration.", "authors": [{"family": "Uche", "given": "Enoch Ogbonnaya", "initials": "EO"}, {"family": "Sundblom", "given": "Jimmy", "initials": "J"}, {"family": "Iloabachie", "given": "Izuchukwu", "initials": "I"}, {"family": "Ozoh", "given": "Ignatius I", "initials": "II"}, {"family": "Alalade", "given": "Andrew", "initials": "A"}, {"family": "Revesz", "given": "David", "initials": "D"}, {"family": "Sandvik", "given": "Ulrika", "initials": "U"}, {"family": "Olsson", "given": "Martin", "initials": "M"}, {"family": "Mezue", "given": "Wilfred C", "initials": "WC"}, {"family": "Tisell", "given": "Magnus", "initials": "M"}, {"family": "Ryttlefors", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2022-01-21", "journal": {"title": "Acta Neurochir (Wien)", "issn": "0942-0940", "issn-l": "0001-6268"}, "abstract": "Disruptions in global surgery educational routines by the COVID-19 pandemic have elicited demands for alternative formats for rendering qualitative neurosurgical education. This study presents application of a novel model of online neurosurgical course, the Lecture-Panel-Discussion Model (LPDM).\n\nThis is a cross-sectional survey of participants who attended the Swedish African Neurosurgery Collaboration (SANC)-100A course. Participants evaluated the course through an online self-administered questionnaire using a 5-point Likert scale ranging from very poor-1, poor-2, average (fair)-3, good-4, to excellent-5. SANC-100A comprises a tripod of Lectures, Panel review, and interactive case Discussion. This model (LPDM) was innovated by SANC and applied at the Enugu International Neurosurgery course in February 2021.\n\nThere were 71 attendees, 19 were course faculty, while 52 were participants. Thirty-five attended from Nigeria, 11 from Sweden, 3 from Malawi, 2 from Senegal, and 1 from the UK. Among 44 participants who completed the questionnaire, there were 9 fellows and 35 residents. The overall median course Likert rating was 4.65 \u00b1 0.1. The median overall rating for course events was similar between day 1 (Likert score = 4.45) and day 2 (Likert score = 4.55), U = 55, Z score = 1.10, P = 0.27. The median rating for lectures was 4.50 \u00b1 0.2 and varied from 4.40 on day 1 to 4.55 on day 2. The median rating for panel review was 4.60 \u00b1 0.1 and varied from 4.55 on day 1 to 4.65 on day 2. Interactive case discussions were rated 4.80 on both course days. There was a significant variability in the rating profiles of the course tripod: U = 24.5, P = 0.03. Fifty-one (98%) participants believe LPDM was COVID-19-compliant, while 90% believe the course was beneficial to training and practice.\n\nInitial application of LPDM is rewarded with both high acceptance and high rating among participants.", "doi": "10.1007/s00701-021-05071-z", "pmid": "35059854", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00701-021-05071-z"}], "notes": [], "created": "2022-01-26T10:20:45.277Z", "modified": "2022-01-26T10:20:45.291Z"}, {"entity": "publication", "iuid": "92f14a1b80b249c09fd7efedcc332a40", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/92f14a1b80b249c09fd7efedcc332a40.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/92f14a1b80b249c09fd7efedcc332a40"}}, "title": "Participatory research in times of COVID-19 and beyond: Adjusting your methodological toolkits.", "authors": [{"family": "Sattler", "given": "Claudia", "initials": "C"}, {"family": "Rommel", "given": "Jens", "initials": "J"}, {"family": "Chen", "given": "Cheng", "initials": "C"}, {"family": "Garc\u00eda-Llorente", "given": "Marina", "initials": "M"}, {"family": "Guti\u00e9rrez-Brice\u00f1o", "given": "In\u00e9s", "initials": "I"}, {"family": "Prager", "given": "Katrin", "initials": "K"}, {"family": "Reyes", "given": "Maria F", "initials": "MF"}, {"family": "Schr\u00f6ter", "given": "Barbara", "initials": "B"}, {"family": "Schulze", "given": "Christoph", "initials": "C"}, {"family": "van Bussel", "given": "Lenny G J", "initials": "LGJ"}, {"family": "Loft", "given": "Lasse", "initials": "L"}, {"family": "Matzdorf", "given": "Bettina", "initials": "B"}, {"family": "Kelemen", "given": "Eszter", "initials": "E"}], "type": "journal article", "published": "2022-01-21", "journal": {"title": "One Earth", "issn": "2590-3322", "volume": "5", "issue": "1", "pages": "62-73", "issn-l": null}, "abstract": "Solving grand environmental societal challenges calls for transdisciplinary and participatory methods in social-ecological research. These methods enable co-designing the research, co-producing the results, and co-creating the impacts together with concerned stakeholders. COVID-19 has had serious impacts on the choice of research methods, but reflections on recent experiences of \"moving online\" are still rare. In this perspective, we focus on the challenge of adjusting different participatory methods to online formats used in five transdisciplinary social-ecological research projects. The key added value of our research is the lessons learned from a comparison of the pros and cons of adjusting a broader set of methods to online formats. We conclude that combining the adjusted online approaches with well-established face-to-face formats into more inclusive hybrid approaches can enrich and diversify the pool of available methods for postpandemic research. Furthermore, a more diverse group of participants can be engaged in the research process.", "doi": "10.1016/j.oneear.2021.12.006", "pmid": "35098107", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2590-3322(21)00724-7"}, {"db": "pmc", "key": "PMC8779601"}], "notes": [], "created": "2022-02-06T16:55:58.322Z", "modified": "2022-02-06T16:55:58.360Z"}, {"entity": "publication", "iuid": "8e0d6a9eb1764446be31099616f108c4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e0d6a9eb1764446be31099616f108c4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e0d6a9eb1764446be31099616f108c4"}}, "title": "T cell immune responses following vaccination with mRNA BNT162b2 against SARS-CoV-2 in patients with chronic lymphocytic leukemia: results from a prospective open-label clinical trial.", "authors": [{"family": "Blixt", "given": "Lisa", "initials": "L"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Lundin", "given": "Jeanette", "initials": "J"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Lange", "given": "Joshua", "initials": "J"}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2022-01-20", "journal": {"title": "Haematologica", "issn": "1592-8721", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Not available.", "doi": "10.3324/haematol.2021.280300", "pmid": "35045694", "labels": {"Category: Health": null, "Research Area: Vaccine": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null, "Category: Biochemistry": null, "Funder: VR": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-27T07:06:13.587Z", "modified": "2022-02-08T19:16:56.522Z"}, {"entity": "publication", "iuid": "3d77564dec9844b2be0cb5f748485ca0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3d77564dec9844b2be0cb5f748485ca0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3d77564dec9844b2be0cb5f748485ca0"}}, "title": "SARS-CoV-2 infections in children: Understanding diverse outcomes.", "authors": [{"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}], "type": "journal article", "published": "2022-01-20", "journal": {"title": "Immunity", "issn": "1074-7613", "issn-l": null}, "abstract": "SARS-CoV-2 infections mostly lead to mild or even asymptomatic infections in children, but the reasons for this are not fully understood. More efficient local tissue responses, better thymic function, and cross-reactive immunity have all been proposed to explain this. In rare cases of children and young people, but very rarely in adults, post-infectious hyperinflammatory syndromes can develop and be serious. Here, I will discuss our current understanding of SARS-CoV-2 infections in children and hypothesize that a life history and energy allocation perspective might offer an additional explanation to mild infections, viral dynamics, and the higher incidence of rare multisystem inflammatory syndromes in children and young people.", "doi": "10.1016/j.immuni.2022.01.014", "pmid": "35093190", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1074-7613(22)00043-7"}, {"db": "pmc", "key": "PMC8769938"}], "notes": [], "created": "2022-01-24T09:19:30.621Z", "modified": "2022-02-06T17:06:42.917Z"}, {"entity": "publication", "iuid": "e83da5ea90ee4b06bc174c3608e8d23b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e83da5ea90ee4b06bc174c3608e8d23b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e83da5ea90ee4b06bc174c3608e8d23b"}}, "title": "Novel universal SARS-CoV DNA vaccine inducing neutralizing antibodies to huCoV-19/WH01, Beta, Delta and Omicron variants and T cells to Bat-CoV", "authors": [{"family": "Appelberg", "given": "K Sofia", "initials": "KS"}, {"family": "Ahlen", "given": "Gustaf", "initials": "G"}, {"family": "Nikoyan", "given": "Negin", "initials": "N"}, {"family": "Yan", "given": "Jingy", "initials": "J"}, {"family": "Weber", "given": "Sofie", "initials": "S"}, {"family": "Larsson", "given": "Olivia", "initials": "O"}, {"family": "H\u00f6glund", "given": "Urban", "initials": "U"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Weber", "given": "Friedemann", "initials": "F", "orcid": "0000-0001-9737-337X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cfac6ca689c5467396ede57ba57092da.json"}}, {"family": "Perlhamre", "given": "Emma", "initials": "E"}, {"family": "Apro", "given": "Johanna", "initials": "J"}, {"family": "Gidlund", "given": "Eva Karin", "initials": "EK"}, {"family": "Tuvesson", "given": "Ola", "initials": "O"}, {"family": "Cadossi", "given": "Matteo", "initials": "M"}, {"family": "Salati", "given": "SImona", "initials": "S"}, {"family": "Tegel", "given": "Hanna", "initials": "H"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Frelin", "given": "Lars", "initials": "L", "orcid": "0000-0001-7452-1667", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd26ddedec244820a9a1e19f76cc5cf8.json"}}, {"family": "mirazimi", "given": "ali", "initials": "a"}, {"family": "Sallberg", "given": "Matti", "initials": "M", "orcid": "0000-0002-8858-5132", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ef589af054b4f94a635ce4021d19ed6.json"}}], "type": "posted-content", "published": "2022-01-20", "journal": {"title": "Research Square", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.21203/rs.3.rs-1276351/v1", "pmid": null, "labels": {"Category: Health": null, "Category: Omicron VoC": null, "Type: Preprint": null, "Category: Drug Discovery": null, "Category: Vaccines": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2022-01-24T10:55:49.379Z", "modified": "2022-01-26T16:38:06.958Z"}, {"entity": "publication", "iuid": "f302bc3bc1c24074ab1bb8f78b8b243f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f302bc3bc1c24074ab1bb8f78b8b243f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f302bc3bc1c24074ab1bb8f78b8b243f"}}, "title": "High prevalence of olfactory disorders 18 months after contracting COVID-19", "authors": [{"family": "Tognetti", "given": "Arnaud", "initials": "A"}, {"family": "Thunell", "given": "Evelina", "initials": "E"}, {"family": "Olsson", "given": "Mats J", "initials": "MJ"}, {"family": "Greilert", "given": "Nina", "initials": "N"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Lundstr\u00f6m", "given": "Johan N", "initials": "JN", "orcid": "0000-0002-3529-8981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a92f50aea024a1fbf0cfda979efef11.json"}}], "type": "posted-content", "published": "2022-01-20", "journal": {"title": "MedRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.01.20.22269490", "pmid": null, "labels": {"Category: Health": null, "Type: Preprint": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [], "notes": [], "created": "2022-01-24T10:45:16.438Z", "modified": "2022-02-09T10:21:37.412Z"}, {"entity": "publication", "iuid": "2d906d15a3034d36b0d9c471c35ad573", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d906d15a3034d36b0d9c471c35ad573.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d906d15a3034d36b0d9c471c35ad573"}}, "title": "A Workflow of Integrated Resources to Catalyze Network Pharmacology Driven COVID-19 Research.", "authors": [{"family": "Zahor\u00e1nszky-K\u0151halmi", "given": "Gergely", "initials": "G", "orcid": "0000-0002-2534-8770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70698b6bf86944b29f19bbf9c2d86ee0.json"}}, {"family": "Siramshetty", "given": "Vishal B", "initials": "VB"}, {"family": "Kumar", "given": "Praveen", "initials": "P"}, {"family": "Gurumurthy", "given": "Manideep", "initials": "M"}, {"family": "Grillo", "given": "Busola", "initials": "B"}, {"family": "Mathew", "given": "Biju", "initials": "B"}, {"family": "Metaxatos", "given": "Dimitrios", "initials": "D"}, {"family": "Backus", "given": "Mark", "initials": "M"}, {"family": "Mierzwa", "given": "Tim", "initials": "T"}, {"family": "Simon", "given": "Reid", "initials": "R"}, {"family": "Grishagin", "given": "Ivan", "initials": "I"}, {"family": "Brovold", "given": "Laura", "initials": "L"}, {"family": "Math\u00e9", "given": "Ewy A", "initials": "EA", "orcid": "0000-0003-4491-8107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/526c8532f9b844e1b26ff8f4b131aab2.json"}}, {"family": "Hall", "given": "Matthew D", "initials": "MD", "orcid": "0000-0002-5073-442X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5b2d73bea15483db987059eccaf46ad.json"}}, {"family": "Michael", "given": "Samuel G", "initials": "SG"}, {"family": "Godfrey", "given": "Alexander G", "initials": "AG"}, {"family": "Mestres", "given": "Jordi", "initials": "J", "orcid": "0000-0002-5202-4501", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ca82613f43dc465b847d30b08de7c560.json"}}, {"family": "Jensen", "given": "Lars J", "initials": "LJ", "orcid": "0000-0001-7885-715X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0da9399aac04409eb3b87ac9f00728a8.json"}}, {"family": "Oprea", "given": "Tudor I", "initials": "TI", "orcid": "0000-0002-6195-6976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c480e6e946bd4c43ac430fd0309df71e.json"}}], "type": "journal article", "published": "2022-01-20", "journal": {"title": "J Chem Inf Model", "issn": "1549-960X", "issn-l": null}, "abstract": "In the event of an outbreak due to an emerging pathogen, time is of the essence to contain or to mitigate the spread of the disease. Drug repositioning is one of the strategies that has the potential to deliver therapeutics relatively quickly. The SARS-CoV-2 pandemic has shown that integrating critical data resources to drive drug-repositioning studies, involving host-host, host-pathogen, and drug-target interactions, remains a time-consuming effort that translates to a delay in the development and delivery of a life-saving therapy. Here, we describe a workflow we designed for a semiautomated integration of rapidly emerging data sets that can be generally adopted in a broad network pharmacology research setting. The workflow was used to construct a COVID-19 focused multimodal network that integrates 487 host-pathogen, 63 278 host-host protein, and 1221 drug-target interactions. The resultant Neo4j graph database named \"Neo4COVID19\" is made publicly accessible via a web interface and via API calls based on the Bolt protocol. Details for accessing the database are provided on a landing page (https://neo4covid19.ncats.io/). We believe that our Neo4COVID19 database will be a valuable asset to the research community and will catalyze the discovery of therapeutics to fight COVID-19.", "doi": "10.1021/acs.jcim.1c00431", "pmid": "35057621", "labels": {"Category: Health": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-26T10:21:09.747Z", "modified": "2022-01-26T10:21:09.983Z"}, {"entity": "publication", "iuid": "8fb2b02dc0744b3997713ef4b0ec145e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8fb2b02dc0744b3997713ef4b0ec145e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8fb2b02dc0744b3997713ef4b0ec145e"}}, "title": "A Method for Estimating the Number of Infections From the Reported Number of Deaths.", "authors": [{"family": "Br\u00e4nnstr\u00f6m", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Sj\u00f6din", "given": "Henrik", "initials": "H"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}], "type": "journal article", "published": "2022-01-20", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "648545", "issn-l": "2296-2565"}, "abstract": "At the outset of an epidemic, available case data typically underestimate the total number of infections due to insufficient testing, potentially hampering public responses. Here, we present a method for statistically estimating the true number of cases with confidence intervals from the reported number of deaths and estimates of the infection fatality ratio; assuming that the time from infection to death follows a known distribution. While the method is applicable to any epidemic with a significant mortality rate, we exemplify the method by applying it to COVID-19. Our findings indicate that the number of unreported COVID-19 infections in March 2020 was likely to be at least one order of magnitude higher than the reported cases, with the degree of underestimation among the countries considered being particularly high in the United Kingdom.", "doi": "10.3389/fpubh.2021.648545", "pmid": "35111706", "labels": {"Category: Other": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8802715"}], "notes": [], "created": "2022-02-06T16:48:45.724Z", "modified": "2022-02-06T16:48:45.737Z"}, {"entity": "publication", "iuid": "f1d335e823fa47ffaf043b0138ee7479", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1d335e823fa47ffaf043b0138ee7479.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1d335e823fa47ffaf043b0138ee7479"}}, "title": "Overexpression of the SARS-CoV-2 receptor angiotensin converting enzyme 2 in cardiomyocytes of failing hearts.", "authors": [{"family": "Vukusic", "given": "Kristina", "initials": "K"}, {"family": "Thorsell", "given": "Annika", "initials": "A"}, {"family": "Muslimovic", "given": "Aida", "initials": "A"}, {"family": "Jonsson", "given": "Marianne", "initials": "M"}, {"family": "Dellgren", "given": "G\u00f6ran", "initials": "G"}, {"family": "Lindahl", "given": "Anders", "initials": "A"}, {"family": "Sandstedt", "given": "Joakim", "initials": "J"}, {"family": "Hammarsten", "given": "Ola", "initials": "O"}], "type": "journal article", "published": "2022-01-19", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "965", "issn-l": "2045-2322"}, "abstract": "Hospitalized patients who die from Covid-19 often have pre-existing heart disease. The SARS-CoV-2 virus is dependent on the ACE2 receptor to be able to infect cells. It is possible that the strong link between cardiovascular comorbidities and a poor outcome following a SARS-CoV-2 infection is sometimes due to viral myocarditis. The aim was to examine the expression of ACE2 in normal hearts and hearts from patients with terminal heart failure. The ACE2 expression was measured by global quantitative proteomics and RT-qPCR in left ventricular (LV) tissue from explanted hearts. Immunohistochemistry was used to examine ACE2 expression in cardiomyocytes, fibroblasts and endothelial cells. In total, tissue from 14 organ donors and 11 patients with terminal heart failure were included. ACE2 expression was 2.6 times higher in 4 hearts from patients with terminal heart failure compared with 6 healthy donor hearts. The results were confirmed by immunohistochemistry where more than half of cardiomyocytes or fibroblasts showed expression of ACE2 in hearts from patients with terminal heart failure. In healthy donor hearts ACE2 was not expressed or found in few fibroblasts. A small subpopulation of endothelial cells expressed ACE2 in both groups. Upregulated ACE2 expression in cardiomyocytes may increase the risk of SARS-CoV-2 myocarditis in patients with heart failure.", "doi": "10.1038/s41598-022-04956-y", "pmid": "35046458", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-04956-y"}, {"db": "pmc", "key": "PMC8770525"}], "notes": [], "created": "2022-01-27T07:04:03.703Z", "modified": "2022-01-27T07:04:03.717Z"}, {"entity": "publication", "iuid": "6635e3f8535740968c9fdc520dc224e6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6635e3f8535740968c9fdc520dc224e6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6635e3f8535740968c9fdc520dc224e6"}}, "title": "Loss of Y in leukocytes as a risk factor for critical COVID-19 in men", "authors": [{"family": "Bruhn-Olszewska", "given": "Bo\u017cena", "initials": "B", "orcid": "0000-0003-2141-0247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dedfa26bf2d048b7b8e45b5e057c92a1.json"}}, {"family": "Davies", "given": "Hanna", "initials": "H", "orcid": "0000-0002-6289-3815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e47c749e23324a6dbbe27c4fc980d44d.json"}}, {"family": "Sarkisyan", "given": "Daniil", "initials": "D", "orcid": "0000-0002-2451-4386", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e35e9da7e5074089a9c12af2f8fac728.json"}}, {"family": "Juhas", "given": "Ulana", "initials": "U", "orcid": "0000-0001-8393-5845", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2eb6588951114e6ea94c2044e057baa8.json"}}, {"family": "Rychlicka-Buniowska", "given": "Edyta", "initials": "E", "orcid": "0000-0001-8050-2489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/408d42c146da46dcb096476de68870ce.json"}}, {"family": "W\u00f3jcik", "given": "Magdalena", "initials": "M"}, {"family": "Horbacz", "given": "Monika", "initials": "M", "orcid": "0000-0003-1644-2957", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cd269c5ae484ab5bdf9cc96b4e5803d.json"}}, {"family": "J\u0105kalski", "given": "Marcin", "initials": "M", "orcid": "0000-0002-5481-9148", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65510c2de4984c5ab5c221af3c00258e.json"}}, {"family": "Olszewski", "given": "Pawe\u0142", "initials": "P", "orcid": "0000-0002-2788-5254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7546c2273a0b41318e03b0b6b8386644.json"}}, {"family": "Westholm", "given": "Jakub O", "initials": "JO", "orcid": "0000-0002-6849-6220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8f7f8b02a9748f09626d373504ed84d.json"}}, {"family": "Smialowska", "given": "Agata", "initials": "A"}, {"family": "Wierzba", "given": "Karol", "initials": "K", "orcid": "0000-0003-1257-4047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/acaa0094bb054d10bf5b9037e5e05468.json"}}, {"family": "Naluai", "given": "\u00c5sa Torinsson", "initials": "\u00c5T", "orcid": "0000-0002-0504-6492", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ec904138d45463ea133b3ea7a062e08.json"}}, {"family": "Jern", "given": "Niklas", "initials": "N"}, {"family": "Andersson", "given": "Lars Magnus", "initials": "LM", "orcid": "0000-0002-9203-5969", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9cc0ebc0e6d433fbec6ca555a329ca3.json"}}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD", "orcid": "0000-0002-7075-1059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4c50079915c44d39c996741c6156bfa.json"}}, {"family": "Filipowicz", "given": "Natalia", "initials": "N", "orcid": "0000-0002-9673-2649", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf3f9e58fdfe466e8e4a224c0b451878.json"}}, {"family": "Janson", "given": "Eva Tiensuu", "initials": "ET", "orcid": "0000-0002-1649-4880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce68e15ca80a4813b20e055ea8c408c0.json"}}, {"family": "Rubertsson", "given": "Sten", "initials": "S"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Dumanski", "given": "Jan P", "initials": "JP", "orcid": "0000-0002-1489-1452", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f429f169193e41c78e76c206e9540cd8.json"}}], "type": "posted-content", "published": "2022-01-19", "journal": {"title": "MedRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.01.19.22269521", "pmid": null, "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Type: Preprint": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Funder: VR": null, "Research Area: Call 2": null}, "xrefs": [], "notes": [], "created": "2022-01-24T10:47:41.713Z", "modified": "2022-11-22T05:53:59.725Z"}, {"entity": "publication", "iuid": "1048b06d2e1146f2a460ad4b0a260684", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1048b06d2e1146f2a460ad4b0a260684.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1048b06d2e1146f2a460ad4b0a260684"}}, "title": "Assessment of biosafety implementation in clinical diagnostic laboratories in pakistan related to the COVID-19 pandemic.", "authors": [{"family": "Sarwar", "given": "Samreen", "initials": "S"}, {"family": "Shahzad", "given": "Faheem", "initials": "F"}, {"family": "Vajeeha", "given": "Ayesha", "initials": "A"}, {"family": "Munir", "given": "Rimsha", "initials": "R"}, {"family": "Yaqoob", "given": "Amina", "initials": "A"}, {"family": "Naeem", "given": "Aniqa", "initials": "A"}, {"family": "Sattar", "given": "Mamoona", "initials": "M"}, {"family": "Gull", "given": "Sheereen", "initials": "S"}], "type": "journal article", "published": "2022-01-19", "journal": {"title": "J Biosaf Biosecur", "issn": "2588-9338", "issn-l": null}, "abstract": "Laboratory diagnostic capacity is crucial for an optimal national response to a public health emergency such as the COVID-19 pandemic. Preventing laboratory-acquired infections and the loss of critical human resources, especially during a public health emergency, requires laboratories to have a good biorisk management system in place. In this study, we aimed to evaluate laboratory biosafety and biosecurity in Pakistan during the COVID-19 pandemic. In this cross-sectional study, a self-rated anonymous questionnaire was distributed to laboratory professionals (LPs) working in clinical diagnostic laboratories, including laboratories performing polymerase chain reaction (PCR)-based COVID-19 diagnostic testing in Punjab, Sindh, Khyber Pakhtunkhwa, and Gilgit-Baltistan provinces as well as Islamabad during March 2020 to April 2020. The questionnaire assessed knowledge and perceptions of LPs, resource availability, and commitment by top management in these laboratories. In total, 58.6% of LPs performing COVID-19 testing reported that their laboratory did not conduct a biorisk assessment before starting COVID-19 testing in their facility. Only 31% of LPs were aware that COVID-19 testing could be performed at a biosafety level 2 laboratory, as per the World Health Organization interim biosafety guidelines. A sufficiently high percentage of LPs did not feel confident in their ability to handle COVID-19 samples (32.8%), spills (43.1%), or other accidents (32.8%). These findings demonstrate the need for effective biosafety program implementation, proper training, and establishing competency assessment methods. These findings also suggested that identifying and addressing gaps in existing biorisk management systems through sustainable interventions and preparing LPs for surge capacity is crucial to better address public health emergencies.", "doi": "10.1016/j.jobb.2022.01.001", "pmid": "35072000", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2588-9338(22)00001-2"}, {"db": "pmc", "key": "PMC8768056"}], "notes": [], "created": "2022-01-26T10:16:06.535Z", "modified": "2022-01-26T10:16:06.564Z"}, {"entity": "publication", "iuid": "ac9452c851ea4129b2d9be95df87dfe5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac9452c851ea4129b2d9be95df87dfe5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac9452c851ea4129b2d9be95df87dfe5"}}, "title": "The global pandemic and changes in women's reproductive health: an observational study.", "authors": [{"family": "Haile", "given": "Liya", "initials": "L", "orcid": "0000-0001-9170-4879", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a55e8c5467f64375a0bb34018bcb3253.json"}}, {"family": "van de Roemer", "given": "Niels", "initials": "N"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K", "orcid": "0000-0001-6516-1444", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be16fea6bd1042048b8a4008dc005014.json"}}, {"family": "Perell\u00f3 Cap\u00f3", "given": "Josep", "initials": "J"}, {"family": "Lete Lasa", "given": "I\u00f1aki", "initials": "I", "orcid": "0000-0002-0266-3970", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c04f7883288f46889b29558128ed0ed6.json"}}, {"family": "Vannuccini", "given": "Silvia", "initials": "S", "orcid": "0000-0001-5790-587X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a60b6384996455eaf747bba3f2f5be0.json"}}, {"family": "Koch", "given": "Martin C", "initials": "MC"}, {"family": "Hildebrandt", "given": "Thomas", "initials": "T", "orcid": "0000-0002-7605-4465", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1f934af7558459d8e228980d1423995.json"}}, {"family": "Calaf", "given": "Joaquim", "initials": "J", "orcid": "0000-0002-2407-7884", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3750306e7cd4f69a59a3120e08c051d.json"}}], "type": "journal article", "published": "2022-01-18", "journal": {"title": "Eur J Contracept Reprod Health Care", "issn": "1473-0782", "pages": "1-5", "issn-l": null}, "abstract": "The COVID-19 global pandemic has led to the death of millions around the world and impacted the overall health of many people. In this article we aim to compare reproductive health indicators in the first 6 months of 2020 to the prior year, as well as explore stress and quality of life during this time.\n\nThis retrospective observational study examined the menstrual cycles of 1159 women who were using a fertility tracking device to record their menstrual cycle and BBT data. We utilised a supplemental mobile application to administer a supplemental survey to collect data on stress and quality of life. Descriptive analyses were conducted with t-tests for two-group comparisons.\n\nStudy participants from 15 countries contributed to a total of 13,194 cycles. 23.1% (268/1159) responded to the survey focussed on assessing psychosocial distress. 44.4% (119/268) of the study participants reported that they had noticed a change in their menstrual cycle, temperature curve, or menstruation in the past 12 months. Cycle analysis found the average cycle length and pre-ovulation phase length was longer in the first 6 months of 2019, while the average days of menstruation was slightly longer in 2020.\n\nOur findings indicate that menstrual cycle indicators changed only slightly in the first 6 months of 2020 but were still statistically significant. We were also able to understand that these study participants had some level of awareness of changes to their menstrual health.", "doi": "10.1080/13625187.2021.2024161", "pmid": "35040737", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-27T07:10:09.391Z", "modified": "2022-01-27T07:35:46.040Z"}, {"entity": "publication", "iuid": "87391f11a89f41ccbdefccfb22773983", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87391f11a89f41ccbdefccfb22773983.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87391f11a89f41ccbdefccfb22773983"}}, "title": "Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function.", "authors": [{"family": "Martin", "given": "Darren P", "initials": "DP"}, {"family": "Lytras", "given": "Spyros", "initials": "S"}, {"family": "Lucaci", "given": "Alexander G", "initials": "AG"}, {"family": "Maier", "given": "Wolfgang", "initials": "W"}, {"family": "Gr\u00fcning", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Shank", "given": "Stephen D", "initials": "SD"}, {"family": "Weaver", "given": "Steven", "initials": "S"}, {"family": "MacLean", "given": "Oscar A", "initials": "OA"}, {"family": "Orton", "given": "Richard J", "initials": "RJ"}, {"family": "Lemey", "given": "Philippe", "initials": "P"}, {"family": "Boni", "given": "Maciej F", "initials": "MF"}, {"family": "Tegally", "given": "Houriiyah", "initials": "H"}, {"family": "Harkins", "given": "Gordon", "initials": "G"}, {"family": "Scheepers", "given": "Cathrine", "initials": "C"}, {"family": "Bhiman", "given": "Jinal N", "initials": "JN"}, {"family": "Everatt", "given": "Josie", "initials": "J"}, {"family": "Amoako", "given": "Daniel G", "initials": "DG"}, {"family": "San", "given": "James Emmanuel", "initials": "JE"}, {"family": "Giandhari", "given": "Jennifer", "initials": "J"}, {"family": "Sigal", "given": "Alex", "initials": "A"}, {"family": "NGS-SA", "given": "", "initials": ""}, {"family": "Williamson", "given": "Carolyn", "initials": "C"}, {"family": "Hsiao", "given": "Nei-Yuan", "initials": "NY"}, {"family": "von Gottberg", "given": "Anne", "initials": "A"}, {"family": "De Klerk", "given": "Arne", "initials": "A"}, {"family": "Shafer", "given": "Robert W", "initials": "RW"}, {"family": "Robertson", "given": "David L", "initials": "DL"}, {"family": "Wilkinson", "given": "Robert J", "initials": "RJ"}, {"family": "Sewell", "given": "B Trevor", "initials": "BT"}, {"family": "Lessells", "given": "Richard", "initials": "R"}, {"family": "Nekrutenko", "given": "Anton", "initials": "A"}, {"family": "Greaney", "given": "Allison J", "initials": "AJ"}, {"family": "Starr", "given": "Tyler N", "initials": "TN"}, {"family": "Bloom", "given": "Jesse D", "initials": "JD"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Wilkinson", "given": "Eduan", "initials": "E"}, {"family": "Gupta", "given": "Ravindra K", "initials": "RK"}, {"family": "de Oliveira", "given": "Tulio", "initials": "T"}, {"family": "Kosakovsky Pond", "given": "Sergei L", "initials": "SL"}], "type": "preprint", "published": "2022-01-18", "journal": {"title": "bioRxiv", "issn-l": null}, "abstract": "Among the 30 non-synonymous nucleotide substitutions in the Omicron S-gene are 13 that have only rarely been seen in other SARS-CoV-2 sequences. These mutations cluster within three functionally important regions of the S-gene at sites that will likely impact (i) interactions between subunits of the Spike trimer and the predisposition of subunits to shift from down to up configurations, (ii) interactions of Spike with ACE2 receptors, and (iii) the priming of Spike for membrane fusion. We show here that, based on both the rarity of these 13 mutations in intrapatient sequencing reads and patterns of selection at the codon sites where the mutations occur in SARS-CoV-2 and related sarbecoviruses, prior to the emergence of Omicron the mutations would have been predicted to decrease the fitness of any genomes within which they occurred. We further propose that the mutations in each of the three clusters therefore cooperatively interact to both mitigate their individual fitness costs, and adaptively alter the function of Spike. Given the evident epidemic growth advantages of Omicron over all previously known SARS-CoV-2 lineages, it is crucial to determine both how such complex and highly adaptive mutation constellations were assembled within the Omicron S-gene, and why, despite unprecedented global genomic surveillance efforts, the early stages of this assembly process went completely undetected.", "doi": "10.1101/2022.01.14.476382", "pmid": "35075456", "labels": {"Category: Omicron VoC": null, "Type: Preprint": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8786225"}], "notes": [], "created": "2022-02-23T11:16:48.684Z", "modified": "2022-02-23T11:17:06.235Z"}, {"entity": "publication", "iuid": "9b93133c2f8a45d1927cf1886ac94805", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b93133c2f8a45d1927cf1886ac94805.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b93133c2f8a45d1927cf1886ac94805"}}, "title": "Potential role of neurofilament in COVID-19 and preeclampsia.", "authors": [{"family": "Samara", "given": "Athina", "initials": "A"}, {"family": "Herlenius", "given": "Eric", "initials": "E"}, {"family": "O' Brien", "given": "Patrick", "initials": "P"}, {"family": "Khalil", "given": "Asma", "initials": "A"}], "type": "news", "published": "2022-01-18", "journal": {"title": "Cell Rep Med", "issn": "2666-3791", "volume": "3", "issue": "1", "pages": "100490", "issn-l": "2666-3791"}, "abstract": "Neurofilament light (NFL) is a promising circulating biomarker in preeclampsia and COVID-19, even without evident neurological complications. Several pathways might contribute to the elevated serum NFL levels seen in both pathologies. Future studies will determine whether NFL is a long COVID marker and delineate NFL's role in COVID-19-associated preeclampsia.", "doi": "10.1016/j.xcrm.2021.100490", "pmid": "35103255", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2666-3791(21)00367-0"}, {"db": "pmc", "key": "PMC8764750"}], "notes": [], "created": "2022-02-06T16:51:21.210Z", "modified": "2022-02-06T16:51:21.225Z"}, {"entity": "publication", "iuid": "e409259f8b5c49bca0bd43c1a5e47f07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e409259f8b5c49bca0bd43c1a5e47f07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e409259f8b5c49bca0bd43c1a5e47f07"}}, "title": "Politicians polarize and experts depolarize public support for COVID-19 management policies across countries.", "authors": [{"family": "Flores", "given": "Alexandra", "initials": "A"}, {"family": "Cole", "given": "Jennifer C", "initials": "JC"}, {"family": "Dickert", "given": "Stephan", "initials": "S"}, {"family": "Eom", "given": "Kimin", "initials": "K"}, {"family": "Jiga-Boy", "given": "Gabriela M", "initials": "GM", "orcid": "0000-0003-3163-8798", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dac90441cd3642eabb3ed61932ba22db.json"}}, {"family": "Kogut", "given": "Tehila", "initials": "T", "orcid": "0000-0001-8652-5112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56c2ee61d26b45c799115f41b68d6c77.json"}}, {"family": "Loria", "given": "Riley", "initials": "R"}, {"family": "Mayorga", "given": "Marcus", "initials": "M", "orcid": "0000-0001-5471-0655", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d12c67fe7be433282cdecf395edca4a.json"}}, {"family": "Pedersen", "given": "Eric J", "initials": "EJ"}, {"family": "Pereira", "given": "Beatriz", "initials": "B", "orcid": "0000-0002-1091-0943", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b713e52b7d4744f2bd2de606a92dae2f.json"}}, {"family": "Rubaltelli", "given": "Enrico", "initials": "E", "orcid": "0000-0002-7521-755X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2283c6a303c24124a700b154b2d62b97.json"}}, {"family": "Sherman", "given": "David K", "initials": "DK"}, {"family": "Slovic", "given": "Paul", "initials": "P", "orcid": "0000-0002-7473-6403", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e42d731725348998fcff156270435f5.json"}}, {"family": "V\u00e4stfj\u00e4ll", "given": "Daniel", "initials": "D"}, {"family": "Van Boven", "given": "Leaf", "initials": "L", "orcid": "0000-0003-4187-8779", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd5678aef638457dab8264e41775c3dc.json"}}], "type": "journal article", "published": "2022-01-18", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "119", "issue": "3", "issn-l": "0027-8424"}, "abstract": "Political polarization impeded public support for policies to reduce the spread of COVID-19, much as polarization hinders responses to other contemporary challenges. Unlike previous theory and research that focused on the United States, the present research examined the effects of political elite cues and affective polarization on support for policies to manage the COVID-19 pandemic in seven countries (n = 12,955): Brazil, Israel, Italy, South Korea, Sweden, the United Kingdom, and the United States. Across countries, cues from political elites polarized public attitudes toward COVID-19 policies. Liberal and conservative respondents supported policies proposed by ingroup politicians and parties more than the same policies from outgroup politicians and parties. Respondents disliked, distrusted, and felt cold toward outgroup political elites, whereas they liked, trusted, and felt warm toward both ingroup political elites and nonpartisan experts. This affective polarization was correlated with policy support. These findings imply that policies from bipartisan coalitions and nonpartisan experts would be less polarizing, enjoying broader public support. Indeed, across countries, policies from bipartisan coalitions and experts were more widely supported. A follow-up experiment replicated these findings among US respondents considering international vaccine distribution policies. The polarizing effects of partisan elites and affective polarization emerged across nations that vary in cultures, ideologies, and political systems. Contrary to some propositions, the United States was not exceptionally polarized. Rather, these results suggest that polarizing processes emerged simply from categorizing people into political ingroups and outgroups. Political elites drive polarization globally, but nonpartisan experts can help resolve the conflicts that arise from it.", "doi": "10.1073/pnas.2117543119", "pmid": "35042779", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2117543119"}], "notes": [], "created": "2022-01-27T07:06:55.025Z", "modified": "2022-01-27T07:06:55.297Z"}, {"entity": "publication", "iuid": "be6c92969d4f4a0eb3c57bee4076a14e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be6c92969d4f4a0eb3c57bee4076a14e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be6c92969d4f4a0eb3c57bee4076a14e"}}, "title": "Impact of the COVID-19 pandemic on the incidence and mortality of hospital-onset bloodstream infection: a cohort study.", "authors": [{"family": "Valik", "given": "John Karlsson", "initials": "JK", "orcid": "0000-0002-4521-1886", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eac431272ad4d8eb13c8d56ddef182c.json"}}, {"family": "Hedberg", "given": "Pontus", "initials": "P"}, {"family": "Holmberg", "given": "Fredrik", "initials": "F"}, {"family": "van der Werff", "given": "Suzanne Desir\u00e9e", "initials": "SD"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2022-01-18", "journal": {"title": "BMJ Qual Saf", "issn": "2044-5423", "issn-l": null}, "abstract": "The COVID-19 pandemic burdens hospitals, but consequences for quality of care outcomes such as healthcare-associated infections are largely unknown. This cohort included all adult hospital episodes (n=186 945) at an academic centre between January 2018 and January 2021. Data were collected from the hospitals' electronic health record data repository. Hospital-onset bloodstream infection (HOB) was defined as any positive blood culture obtained \u226548 hours after admission classified based on microbiological and hospital administrative data. Subgroup analyses were performed with exclusion of potential contaminant bacteria. The cohort was divided into three groups: controls (prepandemic period), non-COVID-19 (pandemic period) and COVID-19 (pandemic period) based on either PCR-confirmed SARS-CoV-2 infections from respiratory samples or International Classification of Diseases 10th Revision diagnoses U071 and U72 at discharge. Adjusted incidence rate ratios (aIRR) and risk of death in patients with HOB were compared between the prepandemic and pandemic periods using Poisson and logistic regression. The incidence of HOB was increased for the COVID-19 group compared with the prepandemic period (aIRR 3.34, 95% CI 2.97 to 3.75). In the non-COVID-19 group, the incidence was slightly increased compared with prepandemic levels (aIRR 1.20, 95% CI 1.08 to 1.32), but the difference decreased when excluding potential contaminant bacteria (aIRR 1.15, 95% CI 1.00 to 1.31, p=0.04). The risk of dying increased for both the COVID-19 group (adjusted odds ratio (aOR) 2.44, 95% CI 1.75 to 3.38) and the non-COVID-19 group (aOR 1.63, 95% CI 1.22 to 2.16) compared with the prepandemic controls. These findings were consistent also when excluding potential contaminants. In summary, we observed a higher incidence of HOB during the COVID-19 pandemic, and the mortality risk associated with HOB was greater, compared with the prepandemic period. Results call for specific attention to quality of care during the pandemic.", "doi": "10.1136/bmjqs-2021-014243", "pmid": "35042764", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjqs-2021-014243"}], "notes": [], "created": "2022-01-27T07:07:10.389Z", "modified": "2022-01-27T07:07:10.470Z"}, {"entity": "publication", "iuid": "782143d0f4d244e4864d0676fde7793d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/782143d0f4d244e4864d0676fde7793d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/782143d0f4d244e4864d0676fde7793d"}}, "title": "How has the University Community Been Coping During the COVID-19 Pandemic? An Iranian Survey.", "authors": [{"family": "Ahmadi", "given": "Fereshteh", "initials": "F"}, {"family": "Cetrez", "given": "\u00d6nver A", "initials": "\u00d6A"}, {"family": "Akhavan", "given": "Sharareh", "initials": "S"}, {"family": "Khodayarifard", "given": "Mohammad", "initials": "M"}, {"family": "Zandi", "given": "Saeid", "initials": "S"}], "type": "journal article", "published": "2022-01-18", "journal": {"title": "Front Sociol", "issn": "2297-7775", "issn-l": null, "volume": "6", "issue": null, "pages": "645670"}, "abstract": "Objectives: The present study, one of the first to look at COVID-19 and coping in Iran, aimed at mapping, describing and understanding the coping methods academics employ as protective resources to deal with the psychological challenges and social isolation during the COVID-19 pandemic. We specifically aimed at identifying the meaning-making coping methods used and understanding the influence of culture. The guiding research question has been: Are there differences in meaning-making coping methods by gender, age group, work/student status, and place of residence? Design: The study, which used convenience sampling, was a quantitative inquiry. It employed a modified version of the RCOPE scale among faculty/staff members and students in Iran (n = 196, 75% women). Results: The most frequently used coping method among all subgroups of the study sample was thinking that life is part of a greater whole, followed by praying to Allah/God. The least used coping methods were the negative religious ones. Gender differences were found for being alone and contemplating, stronger for men. Thinking that life is part of a greater whole was found mainly among on-campus students. Praying to Allah/God was most common among the youngest staff and students, as well as among women. Two segments of respondents were discovered-the Theists and Non-theists-where the former used more religious coping methods, were more likely to be women, older staff and students, on-campus students, married, have children, and lived in capital. Conclusions: Our conclusion is that the RCOPE methods, which include religious and spiritual meaning-making methods, are of great importance to the studied Iranian informants. However, they use some secular existential meaning-making coping strategies too. This is explained by the role of religion in the larger orientation system and frame of reference in parallel with a secular worldview. Further, a sharp distinction between religious and secular worldviews was not found, which is explained by the fact that secular norms are hardly internalized in ways of thinking in Iran.", "doi": "10.3389/fsoc.2021.645670", "pmid": "35118154", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "645670"}, {"db": "pmc", "key": "PMC8804233"}], "notes": [], "created": "2022-02-06T16:46:47.401Z", "modified": "2022-11-22T05:40:56.916Z"}, {"entity": "publication", "iuid": "8e579aec7c4344b894b2a8a236a106ba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e579aec7c4344b894b2a8a236a106ba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e579aec7c4344b894b2a8a236a106ba"}}, "title": "Can They Stay or Will They Go? A Cross Sectional Study of Managers' Attitudes towards Their Senior Employees.", "authors": [{"family": "Nilsson", "given": "Kerstin", "initials": "K", "orcid": "0000-0002-3193-205X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81335f480e0d4c7590701b5a164c269e.json"}}, {"family": "Nilsson", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2022-01-18", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "3", "issn-l": null}, "abstract": "A larger amount of older people need to participate in working life due to the global demographic change. It is the employer, through the manager, who enables employees to have access to measures in the workplace that facilitate and enable a sustainable extended working life. The aim of this study was to evaluate work life factors associated with managers believing their employees can work versus wanting to work until age 65 or older. This cross-sectional study included 249 managers in the Swedish municipality sector. Logistic regression analysis was used to investigate associations between different univariate estimates and in data modelling using the SwAge-model. The result stated that 79% of managers believed their employees 'can' work and 58% of managers believed their employees 'want to' work until age 65 or older. Health, physical work environment, skills and competence are associated the strongest to managers believing employees 'can' work until age 65 or older. Insufficient social support at work and lacking possibilities for relocations associated the strongest to managers believing employees would not 'want to' work until age 65 or older. Though, several countries (especially in Europe) have included in their social policy measures that retirement age be increased after 65, proposing ages approaching 70. When these proposals become laws, through obligation, people will have no choice (if they want to or if they can continue working). However, people's attitudes to work may be different (especially after the COVID-19 pandemic), and this analysis of the participating managers' attitudes showed there is a difference between why employees 'can' versus 'want' to work respectively. Therefore, different strategies may be needed to contribute to employees both being able to and willing to participate in working life until an older age. These findings on managers' perspectives, regarding whether they believe employees would be able to versus would want to work and the SwAge-model, will hopefully contribute to an increased understanding of organisational actions and measures in the process of creating a sustainable extended working life and to increase senior employees' employability.", "doi": "10.3390/ijerph19031057", "pmid": "35162080", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19031057"}], "notes": [], "created": "2022-02-17T06:10:01.874Z", "modified": "2022-02-17T06:10:15.286Z"}, {"entity": "publication", "iuid": "90a1865683244d27a10a4f43f5f9bd8d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90a1865683244d27a10a4f43f5f9bd8d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90a1865683244d27a10a4f43f5f9bd8d"}}, "title": "COVID-19 Severity and Cardiovascular Disease: An Inseparable Link.", "authors": [{"family": "Henein", "given": "Michael Y", "initials": "MY", "orcid": "0000-0002-6089-5614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe79bb10eb4348948599443b7b396faf.json"}}, {"family": "Cameli", "given": "Matteo", "initials": "M", "orcid": "0000-0003-3872-8964", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e64899d051a84cd8a0cac5f503e03251.json"}}, {"family": "Pastore", "given": "Maria Concetta", "initials": "MC", "orcid": "0000-0002-7223-141X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/55e79d1bf0294864ae1cdb57aa4a4844.json"}}, {"family": "Mandoli", "given": "Giulia Elena", "initials": "GE", "orcid": "0000-0002-3184-3006", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc927b7843b44bdd87232563c7faff19.json"}}], "type": "editorial", "published": "2022-01-18", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "11", "issue": "3", "issn-l": "2077-0383"}, "abstract": "The COVID-19 pandemic is a global health issue that has so far affected over 250 million people worldwide [...].", "doi": "10.3390/jcm11030479", "pmid": "35159931", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "jcm11030479"}], "notes": [], "created": "2022-02-17T06:11:18.116Z", "modified": "2022-02-17T06:11:32.211Z"}, {"entity": "publication", "iuid": "6cff8b952d0f4794bf399b05db141eb3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6cff8b952d0f4794bf399b05db141eb3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6cff8b952d0f4794bf399b05db141eb3"}}, "title": "Perceived Changes in Sexual Interest and Distress About Discrepant Sexual Interest During the First Phase of COVID-19 Pandemic: A Multi-Country Assessment in Cohabiting Partnered Individuals.", "authors": [{"family": "\u0160tulhofer", "given": "Aleksandar", "initials": "A", "orcid": "0000-0001-5138-3644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1eaa60cb1a874757ab9306915557c39c.json"}}, {"family": "Mehuli\u0107", "given": "Jasmina", "initials": "J"}, {"family": "Briken", "given": "Peer", "initials": "P"}, {"family": "Klapilov\u00e1", "given": "Kate\u0159ina", "initials": "K"}, {"family": "de Graaf", "given": "Hanneke", "initials": "H"}, {"family": "Carvalheira", "given": "Ana Alexandra", "initials": "AA"}, {"family": "L\u00f6fgren-M\u00e5rtenson", "given": "Charlotta", "initials": "C"}, {"family": "Nobre", "given": "Pedro", "initials": "P"}, {"family": "Chollier", "given": "Marie", "initials": "M"}, {"family": "K\u00f6se", "given": "\u00d6zlem", "initials": "\u00d6"}, {"family": "Elmerstig", "given": "Eva", "initials": "E"}, {"family": "Lan\u00e7on", "given": "Christophe", "initials": "C"}, {"family": "Pl\u00e1\u0161ilov\u00e1", "given": "Leona", "initials": "L"}, {"family": "Schr\u00f6der", "given": "Johanna", "initials": "J"}], "type": "journal article", "published": "2022-01-17", "journal": {"title": "Arch Sex Behav", "issn": "1573-2800", "issn-l": "0004-0002"}, "abstract": "Due to COVID-19 pandemic, different restrictive measures in terms of physical distancing and lockdowns have been introduced in most European countries, affecting all facets of social life. Currently, little is known about how partnered individuals perceive changes in their sexual life during this complex emergency. This study explored retrospectively assessed changes in sexual interest for one's partner and levels of distress related to perceived sexual interest discrepancy during the first phase of the pandemic in a large-scale online sample of partnered individuals (n = 4813; Mage = 38.5 years, SD = 10.74) recruited between May and July 2020 in seven European Union countries and Turkey. We also examined the possible role of approach/avoidance motives for sex in reported changes in sexual interest and associated distress. Most participants (53%) reported no change in their sexual interest during the pandemic, followed by those who reported an increase (28.5%). The pattern was similar across the eight countries. Distress about discrepant sexual interest, which was only weakly related to changes in sexual interest, was significantly associated with relationship quality and emotional closeness with a partner, coping with and worrying about the pandemic, and specific motivation for sex. In contrast to avoidant and relationship-focused approach motivation, ego-focused approach motivation was related to stable sexual interest during the pandemic. The current study contributes to the understanding of the link between sexual interest and complex emergencies. Considering that the COVID-19 pandemic continues, the reported experiences and perceptions are prone to change.", "doi": "10.1007/s10508-021-02279-z", "pmid": "35039982", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10508-021-02279-z"}, {"db": "pmc", "key": "PMC8763301"}], "notes": [], "created": "2022-01-27T07:36:01.051Z", "modified": "2022-01-27T07:36:01.110Z"}, {"entity": "publication", "iuid": "65f8bc7f05004142a11717a6c44b2815", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65f8bc7f05004142a11717a6c44b2815.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65f8bc7f05004142a11717a6c44b2815"}}, "title": "Multiomics integration-based molecular characterizations of COVID-19.", "authors": [{"family": "Li", "given": "Chuan-Xing", "initials": "CX", "orcid": "0000-0003-2189-5010", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b85683a869f446be80700b375582d4d3.json"}}, {"family": "Gao", "given": "Jing", "initials": "J", "orcid": "0000-0002-7732-456X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ec4995699874336b6f0eca4f9812fd5.json"}}, {"family": "Zhang", "given": "Zicheng", "initials": "Z"}, {"family": "Chen", "given": "Lu", "initials": "L"}, {"family": "Li", "given": "Xun", "initials": "X"}, {"family": "Zhou", "given": "Meng", "initials": "M"}, {"family": "Wheelock", "given": "\u00c5sa M", "initials": "\u00c5M"}], "type": "journal article", "published": "2022-01-17", "journal": {"title": "Brief Bioinform", "issn": "1477-4054", "volume": "23", "issue": "1", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rapidly became a global health challenge, leading to unprecedented social and economic consequences. The mechanisms behind the pathogenesis of SARS-CoV-2 are both unique and complex. Omics-scale studies are emerging rapidly and offer a tremendous potential to unravel the puzzle of SARS-CoV-2 pathobiology, as well as moving forward with diagnostics, potential drug targets, risk stratification, therapeutic responses, vaccine development and therapeutic innovation. This review summarizes various aspects of understanding multiomics integration-based molecular characterizations of COVID-19, which to date include the integration of transcriptomics, proteomics, genomics, lipidomics, immunomics and metabolomics to explore virus targets and developing suitable therapeutic solutions through systems biology tools. Furthermore, this review also covers an abridgment of omics investigations related to disease pathogenesis and virulence, the role of host genetic variation and a broad array of immune and inflammatory phenotypes contributing to understanding COVID-19 traits. Insights into this review, which combines existing strategies and multiomics integration profiling, may help further advance our knowledge of COVID-19.", "doi": "10.1093/bib/bbab485", "pmid": "34864875", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC8769889"}, {"db": "pii", "key": "6447675"}], "notes": [], "created": "2023-01-13T13:28:31.791Z", "modified": "2023-07-13T11:29:23.254Z"}, {"entity": "publication", "iuid": "92bd885f2293490888030e991224833d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/92bd885f2293490888030e991224833d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/92bd885f2293490888030e991224833d"}}, "title": "Healthcare use in 700 000 children and adolescents for six months after covid-19: before and after register based cohort study.", "authors": [{"family": "Magnusson", "given": "Karin", "initials": "K", "orcid": "0000-0003-4851-5794", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2fe6a28f36f40a998b8c9fc3c5ebe73.json"}}, {"family": "Skyrud", "given": "Katrine Damgaard", "initials": "KD"}, {"family": "Suren", "given": "P\u00e5l", "initials": "P"}, {"family": "Greve-Isdahl", "given": "Margrethe", "initials": "M"}, {"family": "St\u00f8rdal", "given": "Ketil", "initials": "K"}, {"family": "Kristoffersen", "given": "Doris Tove", "initials": "DT"}, {"family": "Telle", "given": "Kjetil", "initials": "K"}], "type": "journal article", "published": "2022-01-17", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "376", "pages": "e066809", "issn-l": null}, "abstract": "To explore whether and for how long use of healthcare services is increased among children and adolescents after covid-19.\n\nBefore and after register based study.\n\nGeneral population of Norway.\n\nNorwegians aged 1-19 years (n=706 885) who were tested for SARS-CoV-2 from 1 August 2020 to 1 February 2021 (n=10 279 positive, n=275 859 negative) or not tested (n=420 747) and were not admitted to hospital, by age groups 1-5, 6-15, and 16-19 years.\n\nMonthly percentages of all cause and cause specific healthcare use in primary care (general practitioner, emergency ward) and specialist care (outpatient, inpatient) from six months before to about six months after the week of being tested for SARS-CoV-2, using a difference-in-differences approach.\n\nA substantial short term relative increase in primary care use was observed for participants during the first month after a positive SARS-CoV-2 test result compared with those who tested negative (age 1-5 years: 339%, 95% confidence interval 308% to 369%; 6-15 years: 471%, 450% to 491%; 16-19 years: 401%, 380% to 422%). Use of primary care for the younger age groups was still increased at two months (1-5 years: 22%, 4% to 40%; 6-15 years: 14%, 2% to 26%) and three months (1-5 years: 26%, 7% to 46%, 6-15 years: 15%, 3% to 28%), but not for the oldest group (16-19 years: 11%, -2% to 24% and 6%, -7% to 19%, respectively). Children aged 1-5 years who tested positive also showed a minor long term (\u22646 months) relative increase in primary care use (13%, -0% to 26%) that was not observed for the older age groups, compared with same aged children who tested negative. Results were similar yet the age differences less pronounced compared with untested controls. For all age groups, the increase in primary care visits was due to respiratory and general or unspecified conditions. No increased use of specialist care was observed.\n\nCovid-19 among children and adolescents was found to have limited impact on healthcare services in Norway. Preschool aged children might take longer to recover (3-6 months) than primary or secondary school students (1-3 months), usually because of respiratory conditions.", "doi": "10.1136/bmj-2021-066809", "pmid": "35039315", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8762452"}], "notes": [], "created": "2022-01-27T07:38:14.686Z", "modified": "2022-01-27T07:38:14.743Z"}, {"entity": "publication", "iuid": "7dd32d0115a74a9aa9d819dcd6f91cf8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7dd32d0115a74a9aa9d819dcd6f91cf8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7dd32d0115a74a9aa9d819dcd6f91cf8"}}, "title": "Severe multisystem inflammatory syndrome (MIS-C/A) after confirmed SARS-CoV-2 infection: a report of four adult cases", "authors": [{"family": "Sansone", "given": "M", "initials": "M"}, {"family": "Studahl", "given": "M", "initials": "M"}, {"family": "Berg", "given": "S", "initials": "S"}, {"family": "Gissl\u00e9n", "given": "M", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}, {"family": "Sundell", "given": "N", "initials": "N"}], "type": "journal-article", "published": "2022-01-16", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4235", "issn-l": null, "volume": null, "issue": null, "pages": "1-6"}, "abstract": "Multisystem inflammatory syndrome (MIS) triggered by a recent SARS-Cov-2 infection has been recognised worldwide. Although predominantly affecting children (MIS-C), similar presentations have been reported among adults (MIS-A).\n\nA retrospective case series describing four critically ill patients with MIS-C/A diagnosed between January and April 2021 at Sahlgrenska University Hospital, Gothenburg, Sweden. Clinical presentation, laboratory and radiological findings, treatment and outcome are reported.\n\nCases occurred in previously healthy patients with a history of laboratory-confirmed mild SARS-CoV-2 infection four to seven weeks earlier. The median age was 24 years (range 19-43) and 3/4 were male. All fulfilled suggested MIS-C/A criteria according to the US Centre for Disease Control and all required care at an intensive care unit. Treatment was initiated with intravenous immunoglobulin, interleukin-1-receptor antagonists, and pulse steroids in 3/4 cases which resulted in rapid clinical improvement. No severe complications were noticed in any case during a three-month follow-up period.\n\nMIS-C/A should be considered, irrespective of age, in patients with fever, hyperinflammation and multiple organ system involvements emerging weeks after COVID-19. Previously suggested treatment regimens for MIS-C seem to be applicable also for MIS-A.", "doi": "10.1080/23744235.2021.2025422", "pmid": "35034549", "labels": {"Category: Health": null, "Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [], "notes": [], "created": "2022-01-27T07:41:24.997Z", "modified": "2022-02-06T17:32:32.457Z"}, {"entity": "publication", "iuid": "966230056df94b2e846d8626a6add138", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/966230056df94b2e846d8626a6add138.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/966230056df94b2e846d8626a6add138"}}, "title": "Long-term exposure to ambient air pollution and incidence of depression: A population-based cohort study in China.", "authors": [{"family": "Wei", "given": "Fang", "initials": "F"}, {"family": "Yu", "given": "Zhebin", "initials": "Z"}, {"family": "Zhang", "given": "Xinhan", "initials": "X"}, {"family": "Wu", "given": "Mengyin", "initials": "M"}, {"family": "Wang", "given": "Jianbing", "initials": "J"}, {"family": "Shui", "given": "Liming", "initials": "L"}, {"family": "Lin", "given": "Hongbo", "initials": "H"}, {"family": "Jin", "given": "Mingjuan", "initials": "M"}, {"family": "Tang", "given": "Mengling", "initials": "M"}, {"family": "Chen", "given": "Kun", "initials": "K"}], "type": "journal article", "published": "2022-01-15", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "volume": "804", "pages": "149986", "issn-l": "0048-9697"}, "abstract": "Long-term exposure to ambient air pollution was linked to depression incidence, although the results were limited and inconsistent.\n\nTo investigate the effects of long-term air pollution exposure on depression risk prospectively in China.\n\nThe present study used data from Yinzhou Cohort on adults without depression at baseline, and followed up until April 2020. Two-year moving average concentrations of particulate matter with a diameter \u2264 2.5 \u03bcm (PM2.5), \u226410 \u03bcm (PM10) and nitrogen dioxide (NO2) were measured using land-use regression (LUR) models for each participant. Depression cases were ascertained using the Health Information System (HIS) of the local health administration by linking the unique identifiers. We conducted Cox regression models with time-varying exposures to estimate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of depression with each pollutant, after adjusting for a sequence of individual covariates as demographic characteristics, lifestyles, and comorbidity. Besides, physical activity, baseline potential depressive symptoms, cancer status, COVID-19 pandemic, different outcome definitions and air pollution exposure windows were considered in sensitivity analyses.\n\nAmong the 30,712 adults with a mean age of 62.22 \u00b1 11.25, 1024 incident depression cases were identified over totaling 98,619 person-years of observation. Interquartile range increments of the air pollutants were associated with increased risks of depression, and the corresponding HRs were 1.59 (95%CI: 1.46, 1.72) for PM2.5, 1.49 (95%CI: 1.35, 1.64) for PM10 and 1.58 (95%CI: 1.42, 1.77) for NO2. Subgroup analyses suggested that participants without taking any protective measures towards air pollution were more susceptible. The results remained robust in all sensitivity analyses.\n\nLong-term exposure to ambient air pollution was identified as a risk factor for depression onset. Strategies to reduce air pollution are necessary to decrease the disease burden of depression.", "doi": "10.1016/j.scitotenv.2021.149986", "pmid": "34798713", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(21)05061-0"}], "notes": [], "created": "2021-11-26T14:04:59.512Z", "modified": "2021-11-26T14:04:59.526Z"}, {"entity": "publication", "iuid": "5eddcc6107ba40b295898a133c0168eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5eddcc6107ba40b295898a133c0168eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5eddcc6107ba40b295898a133c0168eb"}}, "title": "Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2.", "authors": [{"family": "Bahnan", "given": "Wael", "initials": "W"}, {"family": "Wrighton", "given": "Sebastian", "initials": "S"}, {"family": "Sundwall", "given": "Martin", "initials": "M"}, {"family": "Bl\u00e4ckberg", "given": "Anna", "initials": "A"}, {"family": "Larsson", "given": "Olivia", "initials": "O"}, {"family": "H\u00f6glund", "given": "Urban", "initials": "U"}, {"family": "Khakzad", "given": "Hamed", "initials": "H"}, {"family": "Godzwon", "given": "Magdalena", "initials": "M"}, {"family": "Walle", "given": "Maria", "initials": "M"}, {"family": "Elder", "given": "Elisabeth", "initials": "E"}, {"family": "Strand", "given": "Anna S\u00f6derlund", "initials": "AS"}, {"family": "Happonen", "given": "Lotta", "initials": "L"}, {"family": "Andr\u00e9", "given": "Oscar", "initials": "O"}, {"family": "Ahnlide", "given": "Johannes Kumra", "initials": "JK"}, {"family": "Hellmark", "given": "Thomas", "initials": "T"}, {"family": "Wendel-Hansen", "given": "Vidar", "initials": "V"}, {"family": "Wallin", "given": "Robert Pa", "initials": "RP"}, {"family": "Malmst\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Malmstr\u00f6m", "given": "Lars", "initials": "L"}, {"family": "Ohlin", "given": "Mats", "initials": "M"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}, {"family": "Nordenfelt", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "12", "issue": null, "pages": "808932"}, "abstract": "Spike-specific antibodies are central to effective COVID19 immunity. Research efforts have focused on antibodies that neutralize the ACE2-Spike interaction but not on non-neutralizing antibodies. Antibody-dependent phagocytosis is an immune mechanism enhanced by opsonization, where typically, more bound antibodies trigger a stronger phagocyte response. Here, we show that Spike-specific antibodies, dependent on concentration, can either enhance or reduce Spike-bead phagocytosis by monocytes independently of the antibody neutralization potential. Surprisingly, we find that both convalescent patient plasma and patient-derived monoclonal antibodies lead to maximum opsonization already at low levels of bound antibodies and is reduced as antibody binding to Spike protein increases. Moreover, we show that this Spike-dependent modulation of opsonization correlate with the outcome in an experimental SARS-CoV-2 infection model. These results suggest that the levels of anti-Spike antibodies could influence monocyte-mediated immune functions and propose that non-neutralizing antibodies could confer protection to SARS-CoV-2 infection by mediating phagocytosis.", "doi": "10.3389/fimmu.2021.808932", "pmid": "35095897", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Category: Vaccines": null, "Research Area: Vaccine": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC8796240"}], "notes": [], "created": "2022-01-18T15:28:04.664Z", "modified": "2022-02-08T19:18:01.159Z"}, {"entity": "publication", "iuid": "0d6ac289da3a4cb4bb7423c49a0cf64a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d6ac289da3a4cb4bb7423c49a0cf64a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d6ac289da3a4cb4bb7423c49a0cf64a"}}, "title": "SARS-CoV-2 phase I transmission and mutability linked to the interplay of climatic variables: a global observation on the pandemic spread.", "authors": [{"family": "Sabarathinam", "given": "Chidambaram", "initials": "C"}, {"family": "Mohan Viswanathan", "given": "Prasanna", "initials": "P"}, {"family": "Senapathi", "given": "Venkatramanan", "initials": "V"}, {"family": "Karuppannan", "given": "Shankar", "initials": "S"}, {"family": "Samayamanthula", "given": "Dhanu Radha", "initials": "DR"}, {"family": "Gopalakrishnan", "given": "Gnanachandrasamy", "initials": "G"}, {"family": "Alagappan", "given": "Ramanathan", "initials": "R"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Environ Sci Pollut Res Int", "issn": "1614-7499", "issn-l": null}, "abstract": "The study aims to determine the impact of global meteorological parameters on SARS-COV-2, including population density and initiation of lockdown in twelve different countries. The daily trend of these parameters and COVID-19 variables from February 15th to April 25th, 2020, were considered. Asian countries show an increasing trend between infection rate and population density. A direct relationship between the time-lapse of the first infected case and the period of suspension of movement controls the transmissivity of COVID-19 in Asian countries. The increase in temperature has led to an increase in COVID-19 spread, while the decrease in humidity is consistent with the trend in daily deaths during the peak of the pandemic in European countries. Countries with 65\u00b0F temperature and 5 mm rainfall have a negative impact on COVID-19 spread. Lower oxygen availability in the atmosphere, fine droplets of submicron size together with infectious aerosols, and low wind speed have contributed to the increase in total cases and mortality in Germany and France. The onset of the D614G mutation and subsequent changes to D614 before March, later G614 in mid-March, and S943P, A831V, D839/Y/N/E in April were observed in Asian and European countries. The results of the correlation and factor analysis show that the COVID-19 cases and the climatic factors are significantly correlated with each other. The optimum meteorological conditions for the prevalence of G614 were identified. It was observed that the complex interaction of global meteorological factors and changes in the mutational form of CoV-2 phase I influenced the daily mortality rate along with other comorbid factors. The results of this study could help the public and policymakers to create awareness of the COVID-19 pandemic.", "doi": "10.1007/s11356-021-17481-8", "pmid": "35028838", "labels": {"Category: Genomics & transcriptomics": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11356-021-17481-8"}, {"db": "pmc", "key": "PMC8758228"}], "notes": [], "created": "2022-01-27T08:03:53.271Z", "modified": "2022-01-27T08:03:53.308Z"}, {"entity": "publication", "iuid": "26568a5562674a6aa0dba0ae047d4f41", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26568a5562674a6aa0dba0ae047d4f41.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26568a5562674a6aa0dba0ae047d4f41"}}, "title": "SARS-CoV-2 outbreaks in hospitals and long-term care facilities in Germany: a national observational study.", "authors": [{"family": "Suwono", "given": "Beneditta", "initials": "B"}, {"family": "Steffen", "given": "Annika", "initials": "A"}, {"family": "Schweickert", "given": "Birgitta", "initials": "B"}, {"family": "Sch\u00f6nfeld", "given": "Viktoria", "initials": "V"}, {"family": "Brandl", "given": "Michael", "initials": "M"}, {"family": "Sandfort", "given": "Mirco", "initials": "M"}, {"family": "Willrich", "given": "Niklas", "initials": "N"}, {"family": "Eckmanns", "given": "Tim", "initials": "T"}, {"family": "Haller", "given": "Sebastian", "initials": "S"}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "pages": "100303", "issn-l": null}, "abstract": "Outbreaks of coronavirus disease (COVID-19) in hospitals and long-term care facilities (LTCFs) pose serious public health threats. We analysed how frequency and size of SARS-CoV-2 outbreaks in hospitals and LTCFs have altered since the beginning of the pandemic, in particular since the start of the vaccination campaign.\n\nWe used mandatory notification data on SARS-CoV-2 cases in Germany and stratified by outbreak cases in hospitals and LTCFs. German vaccination coverage data were analysed. We studied the association of the occurrence of SARS-CoV-2 outbreaks and outbreak cases with SARS-CoV-2 cases in Germany throughout the four pandemic waves. We built also counterfactual scenarios with the first pandemic wave as the baseline.\n\nBy 21 September 2021, there were 4,147,387 SARS-CoV-2 notified cases since March 2020. About 20% of these cases were reported as being related to an outbreak, with 1% of the cases in hospitals and 4% in LTCFs. The median number of outbreak cases in the different phases was smaller (\u22645) in hospitals than in LTCFs (>10). In the first and second pandemic waves, we observed strong associations in both facility types between SARS-CoV-2 outbreak cases and total number of notified SARS-CoV-2 cases. However, during the third pandemic wave we observed a decline in outbreak cases in both facility types and only a weak association between outbreak cases and all cases.\n\nThe vaccination campaign and non-pharmaceutical interventions have been able to protect vulnerable risk groups in hospitals and LTCFs.\n\nNo specific funding.", "doi": "10.1016/j.lanepe.2021.100303", "pmid": "35043103", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00289-1"}, {"db": "pmc", "key": "PMC8759004"}], "notes": [], "created": "2022-01-27T07:06:39.744Z", "modified": "2022-01-27T07:06:39.757Z"}, {"entity": "publication", "iuid": "d5b05f520ab34ed8b3f72d7f97878f26", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5b05f520ab34ed8b3f72d7f97878f26.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5b05f520ab34ed8b3f72d7f97878f26"}}, "title": "Perceptions of changes in practice patterns and patient care among heart failure nurses during the COVID-19 pandemic.", "authors": [{"family": "Prasun", "given": "Marilyn A", "initials": "MA"}, {"family": "Blakeman", "given": "John R", "initials": "JR"}, {"family": "Vuckovic", "given": "Karen", "initials": "K"}, {"family": "Kim", "given": "MyoungJin", "initials": "M"}, {"family": "Albert", "given": "Nancy", "initials": "N"}, {"family": "Stamp", "given": "Kelly D", "initials": "KD"}, {"family": "Jaarsma", "given": "Tiny", "initials": "T"}, {"family": "Riegel", "given": "Barbara", "initials": "B"}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Heart Lung", "issn": "1527-3288", "volume": "52", "pages": "152-158", "issn-l": null}, "abstract": "The Coronavirus (COVID-19) had a profound impact on the delivery of care in both hospital and outpatient settings across the United States. Patients with heart failure (HF) and healthcare providers had to abruptly adapt.\n\nTo describe how the COVID-19 pandemic affected practice patterns of HF nurses.\n\nPracticing HF nurses completed a cross-sectional, anonymous, web-based survey of perceptions of HF practice. Analyses involved descriptive and comparative statistics.\n\nOf 171 nurses who completed surveys, outpatient HF visits decreased and 63.2% added telehealth visits. Despite spending about 29 min educating patients during visits, 27.5% of nurses perceived that the pandemic decreased patients' abilities to provide optimal self-care. Nurses reported decreased ability to collect objective data (62.4%; n = 78), although subjective assessment stayed the same (41.6%; n = 52).\n\nNurses' practice patterns provided insight into patient care changes made during COVID-19. Most core components of HF management were retained, but methods of delivery during the pandemic differed.", "doi": "10.1016/j.hrtlng.2022.01.004", "pmid": "35091263", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0147-9563(22)00005-X"}], "notes": [], "created": "2022-01-31T11:42:44.061Z", "modified": "2022-01-31T11:42:44.095Z"}, {"entity": "publication", "iuid": "35b02b7fb97748b09597e7d962742b69", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/35b02b7fb97748b09597e7d962742b69.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/35b02b7fb97748b09597e7d962742b69"}}, "title": "Patients' and clinicians' perspectives on the primary care consultations for acute respiratory infections during the first wave of the COVID-19 pandemic: an eight-country qualitative study in Europe.", "authors": [{"family": "Wanat", "given": "Marta", "initials": "M"}, {"family": "Hoste", "given": "Melanie Eugenie", "initials": "ME"}, {"family": "Gobat", "given": "Nina Helene", "initials": "NH"}, {"family": "Anastasaki", "given": "Marilena", "initials": "M"}, {"family": "B\u00f6hmer", "given": "Femke", "initials": "F"}, {"family": "Chlabicz", "given": "Slawomir", "initials": "S"}, {"family": "Colliers", "given": "Annelies", "initials": "A"}, {"family": "Farrell", "given": "Karen", "initials": "K"}, {"family": "Hollerbach", "given": "Sophie", "initials": "S"}, {"family": "Karkana", "given": "Maria-Nefeli", "initials": "MN"}, {"family": "Kinsman", "given": "John", "initials": "J"}, {"family": "Lionis", "given": "Christos", "initials": "C"}, {"family": "Marcinowicz", "given": "Ludmila", "initials": "L"}, {"family": "Reinhardt", "given": "Katrin", "initials": "K"}, {"family": "Skoglund", "given": "Ingmarie", "initials": "I"}, {"family": "Sundvall", "given": "P\u00e4r-Daniel", "initials": "PD"}, {"family": "Vellinga", "given": "Akke", "initials": "A"}, {"family": "Goossens", "given": "Herman", "initials": "H"}, {"family": "Butler", "given": "Christopher", "initials": "C"}, {"family": "van der Velden", "given": "Alike", "initials": "A"}, {"family": "Anthierens", "given": "Sibyl", "initials": "S"}, {"family": "Tonkin-Crine", "given": "Sarah", "initials": "S"}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "BJGP Open", "issn": "2398-3795", "issn-l": null}, "abstract": "The impact of the COVID-19 pandemic on patients' and clinicians' perceptions of healthcare-seeking behaviour and delivery of care is unclear. The pandemic accelerated the use of remote care and understanding its benefits and drawbacks may inform its implementation during this and future healthcare emergencies.\n\nTo explore patients' and primary care professionals' (PCPs) experiences of primary care delivery in the first wave of the pandemic.\n\nQualitative study using semi-structured interviews in primary care in eight European countries RESULTS: We conducted 146 interviews with 80 PCPs and 66 patients consulting for respiratory tract infection (RTI) symptoms, in eight European countries (England, Ireland, Belgium, the Netherlands, Greece, Poland, Sweden and Germany). Data was collected between April and July 2020 and analysed using thematic analysis. We found that patients accepted telemedicine when PCPs spent time to understand and address their concerns, but a minority preferred in-person consultations. PCPs felt that remote consultations created emotional distance between themselves and patients, and they reported having to manage diverse COVID-19-related medical and social concerns.\n\nRemote consultations for RTI symptoms may be acceptable long-term if both groups are happy to use this format but it is important that PCPs take time to address patients' concerns and provide safety-netting advice.", "doi": "10.3399/BJGPO.2021.0172", "pmid": "35031559", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "BJGPO.2021.0172"}], "notes": [], "created": "2022-01-27T08:02:44.413Z", "modified": "2022-01-27T08:02:44.450Z"}, {"entity": "publication", "iuid": "953bc095647240c7b0f72fe33901310d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/953bc095647240c7b0f72fe33901310d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/953bc095647240c7b0f72fe33901310d"}}, "title": "Mini review ATF4 and GRP78 as novel molecular targets in ER-Stress modulation for critical COVID-19 patients.", "authors": [{"family": "Shahriari-Felordi", "given": "Mahtab", "initials": "M"}, {"family": "Alikhani", "given": "Hani Keshavarz", "initials": "HK"}, {"family": "Hashemian", "given": "Seyed-Mohammad Reza", "initials": "SR"}, {"family": "Hassan", "given": "Moustapha", "initials": "M"}, {"family": "Vosough", "given": "Massoud", "initials": "M", "orcid": "0000-0001-5924-4366", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bf15c1fec524a79b8801694434587e3.json"}}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Mol Biol Rep", "issn": "1573-4978", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in more than 4.4 million deaths worldwide as of August 24, 2021. Viral infections such as SARS-CoV2 are associated with endoplasmic reticulum (ER) stress and also increased the level of reactive oxygen species. Activating transcription factor 4 (ATF4) is preferentially translated under integrated stress conditions and controls the genes involved in protein homeostasis, amino acid transport and metabolism, and also protection from oxidative stress. The GRP78, regulated either directly or indirectly by ATF4, is an essential chaperone in the ER and overexpressed and appears on the surface of almost all cells during stress and function as a SARS-CoV2 receptor. In this mini-review article, we briefly discuss the effects of SARS-CoV2 infection on the ER stress, and then the stress modulator functions of ATF4 and GRP78 as novel therapeutic targets were highlighted. Finally, the effects of GRP78 inhibitory components as potential factors for targeted therapies for COVID-19 critical cases were discussed.", "doi": "10.1007/s11033-021-07071-9", "pmid": "35028855", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11033-021-07071-9"}, {"db": "pmc", "key": "PMC8758217"}], "notes": [], "created": "2022-01-27T08:03:24.300Z", "modified": "2022-01-27T08:03:24.405Z"}, {"entity": "publication", "iuid": "804c55f24f01497f88d27d292dd8fda9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/804c55f24f01497f88d27d292dd8fda9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/804c55f24f01497f88d27d292dd8fda9"}}, "title": "Innovative vaccine approaches-a Keystone Symposia report.", "authors": [{"family": "Cable", "given": "Jennifer", "initials": "J"}, {"family": "Rappuoli", "given": "Rino", "initials": "R"}, {"family": "Klemm", "given": "Elizabeth J", "initials": "EJ"}, {"family": "Kang", "given": "Gagandeep", "initials": "G"}, {"family": "Mutreja", "given": "Ankur", "initials": "A"}, {"family": "Wright", "given": "Gavin J", "initials": "GJ"}, {"family": "Pizza", "given": "Mariagrazia", "initials": "M"}, {"family": "Castro", "given": "Sowmya Ajay", "initials": "SA"}, {"family": "Hoffmann", "given": "Joseph P", "initials": "JP"}, {"family": "Alter", "given": "Galit", "initials": "G"}, {"family": "Carfi", "given": "Andrea", "initials": "A"}, {"family": "Pollard", "given": "Andrew J", "initials": "AJ"}, {"family": "Krammer", "given": "Florian", "initials": "F"}, {"family": "Gupta", "given": "Ravindra K", "initials": "RK"}, {"family": "Wagner", "given": "Caroline E", "initials": "CE"}, {"family": "Machado", "given": "Viviane", "initials": "V"}, {"family": "Modjarrad", "given": "Kayvon", "initials": "K"}, {"family": "Corey", "given": "Lawrence", "initials": "L"}, {"family": "B Gilbert", "given": "Peter", "initials": "P"}, {"family": "Dougan", "given": "Gordon", "initials": "G"}, {"family": "Lurie", "given": "Nicole", "initials": "N"}, {"family": "Bjorkman", "given": "Pamela J", "initials": "PJ"}, {"family": "Chiu", "given": "Christopher", "initials": "C"}, {"family": "Nemes", "given": "Elisa", "initials": "E"}, {"family": "Gordon", "given": "Stephen B", "initials": "SB"}, {"family": "Steer", "given": "Andrew C", "initials": "AC"}, {"family": "Rudel", "given": "Thomas", "initials": "T"}, {"family": "Blish", "given": "Catherine A", "initials": "CA"}, {"family": "Sandberg", "given": "John Tyler", "initials": "JT"}, {"family": "Brennan", "given": "Kiva", "initials": "K"}, {"family": "Klugman", "given": "Keith P", "initials": "KP"}, {"family": "Stuart", "given": "Lynda M", "initials": "LM"}, {"family": "Madhi", "given": "Shabir A", "initials": "SA"}, {"family": "Karp", "given": "Christopher L", "initials": "CL"}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Ann N Y Acad Sci", "issn": "1749-6632", "issn-l": null}, "abstract": "The rapid development of COVID-19 vaccines was the result of decades of research to establish flexible vaccine platforms and understand pathogens with pandemic potential, as well as several novel changes to the vaccine discovery and development processes that partnered industry and governments. And while vaccines offer the potential to drastically improve global health, low-and-middle-income countries around the world often experience reduced access to vaccines and reduced vaccine efficacy. Addressing these issues will require novel vaccine approaches and platforms, deeper insight how vaccines mediate protection, and innovative trial designs and models. On June 28-30, 2021, experts in vaccine research, development, manufacturing, and deployment met virtually for the Keystone eSymposium \"Innovative Vaccine Approaches\" to discuss advances in vaccine research and development.", "doi": "10.1111/nyas.14739", "pmid": "35029310", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2022-01-27T08:03:06.543Z", "modified": "2022-01-27T08:03:06.584Z"}, {"entity": "publication", "iuid": "cd22576c59ec4b4a92e86277221098a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd22576c59ec4b4a92e86277221098a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd22576c59ec4b4a92e86277221098a9"}}, "title": "Exploring the Role of Innate Lymphocytes in the Immune System of Bats and Virus-Host Interactions.", "authors": [{"family": "Sia", "given": "Wan Rong", "initials": "WR"}, {"family": "Zheng", "given": "Yichao", "initials": "Y"}, {"family": "Han", "given": "Fei", "initials": "F"}, {"family": "Chen", "given": "Shiwei", "initials": "S"}, {"family": "Ma", "given": "Shaohua", "initials": "S"}, {"family": "Wang", "given": "Lin-Fa", "initials": "LF", "orcid": "0000-0003-2752-0535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f70fbadea6be4dc69282db33d7bfa8a5.json"}}, {"family": "Leeansyah", "given": "Edwin", "initials": "E", "orcid": "0000-0003-0505-4967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/440347079ebb4d979467290e00173eeb.json"}}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "1", "issn-l": "1999-4915"}, "abstract": "Bats are reservoirs of a large number of viruses of global public health significance, including the ancestral virus for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the causative agent of coronavirus disease 2019 (COVID-19). Although bats are natural carriers of multiple pathogenic viruses, they rarely display signs of disease. Recent insights suggest that bats have a more balanced host defense and tolerance system to viral infections that may be linked to the evolutionary adaptation to powered flight. Therefore, a deeper understanding of bat immune system may provide intervention strategies to prevent zoonotic disease transmission and to identify new therapeutic targets. Similar to other eutherian mammals, bats have both innate and adaptive immune systems that have evolved to detect and respond to invading pathogens. Bridging these two systems are innate lymphocytes, which are highly abundant within circulation and barrier tissues. These cells share the characteristics of both innate and adaptive immune cells and are poised to mount rapid effector responses. They are ideally suited as the first line of defense against early stages of viral infections. Here, we will focus on the current knowledge of innate lymphocytes in bats, their function, and their potential role in host-pathogen interactions. Moreover, given that studies into bat immune systems are often hindered by a lack of bat-specific research tools, we will discuss strategies that may aid future research in bat immunity, including the potential use of organoid models to delineate the interplay between innate lymphocytes, bat viruses, and host tolerance.", "doi": "10.3390/v14010150", "pmid": "35062356", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "v14010150"}], "notes": [], "created": "2022-01-26T10:20:02.038Z", "modified": "2022-01-26T10:20:02.135Z"}, {"entity": "publication", "iuid": "5648e9ee898a42f18e107473e4e2c5cd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5648e9ee898a42f18e107473e4e2c5cd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5648e9ee898a42f18e107473e4e2c5cd"}}, "title": "Cyberchondria, Fear of COVID-19, and Risk Perception Mediate the Association between Problematic Social Media Use and Intention to Get a COVID-19 Vaccine.", "authors": [{"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK", "orcid": "0000-0003-0530-8138", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d442447b551649d8a5372c6bf0075c91.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Chen", "given": "Hsin-Pao", "initials": "HP"}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Timpka", "given": "Toomas", "initials": "T", "orcid": "0000-0001-6049-5402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebcb4fac20f845a4bd9eaa4bf1660ebb.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "1", "issn-l": null}, "abstract": "Vaccination is the most effective way to control the COVID-19 pandemic, but vaccination hesitancy threatens this effort worldwide. Consequently, there is a need to understand what influences individuals' intention to get a COVID-19 vaccine. Restriction of information gathering on societal developments to social media may influence attitudes towards COVID-19 vaccination through exposure to disinformation and imbalanced arguments. The present study examined the association between problematic social media use and intention to get the COVID-19 vaccine, taking into account the mediating roles of cyberchondria, fear of COVID-19, and COVID-19 risk perception. In a cross-sectional survey study, a total of 10,843 residents of Qazvin City, Iran completed measures on problematic social media use, fear of COVID-19, cyberchondria, COVID-19 risk perception, and intention to get a COVID-19 vaccine. The data were analyzed using structural equation modeling (SEM). The results showed that there was no direct association between problematic social media use and intention to get a COVID-19 vaccine. Nonetheless, cyberchondria, fear of COVID-19, and COVID-19 risk perception (each or serially) mediated associations between problematic social media use and intention to get a COVID-19 vaccine. These results add to the understanding of the role of problematic social media use in COVID-19 vaccine hesitancy, i.e., it is not the quantity of social media use per se that matters. This knowledge of the mediating roles of cyberchondria, fear of COVID-19, and COVID-19 risk perception can be used by public health experts and policymakers when planning educational interventions and other initiatives in COVID-19 vaccination programs.", "doi": "10.3390/vaccines10010122", "pmid": "35062783", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "vaccines10010122"}], "notes": [], "created": "2022-01-26T10:18:52.219Z", "modified": "2022-01-26T10:18:52.299Z"}, {"entity": "publication", "iuid": "359626a625b640da95854297479aa467", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/359626a625b640da95854297479aa467.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/359626a625b640da95854297479aa467"}}, "title": "Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19.", "authors": [{"family": "Huffman", "given": "Jennifer E", "initials": "JE", "orcid": "0000-0002-9672-2491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad45db8dbb6a4829ab92daae4d5d027f.json"}}, {"family": "Butler-Laporte", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-5388-0396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/529dc69151d3463e8480b975d70fa759.json"}}, {"family": "Khan", "given": "Atlas", "initials": "A", "orcid": "0000-0002-6651-2725", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1224033b68be41e285c2aba79a4e9b41.json"}}, {"family": "Pairo-Castineira", "given": "Erola", "initials": "E"}, {"family": "Drivas", "given": "Theodore G", "initials": "TG"}, {"family": "Peloso", "given": "Gina M", "initials": "GM", "orcid": "0000-0002-5355-8636", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0baa678d09b4574b98d26876010c8e4.json"}}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T", "orcid": "0000-0001-9510-5646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd273e50091d44c3b3e8d1473ce89b0a.json"}}, {"family": "COVID-19 Host Genetics Initiative", "given": "", "initials": ""}, {"family": "Ganna", "given": "Andrea", "initials": "A"}, {"family": "Verma", "given": "Anurag", "initials": "A"}, {"family": "Baillie", "given": "J Kenneth", "initials": "JK", "orcid": "0000-0001-5258-793X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35a72da3ac10479d87eba693bbe66b4d.json"}}, {"family": "Kiryluk", "given": "Krzysztof", "initials": "K"}, {"family": "Richards", "given": "J Brent", "initials": "JB", "orcid": "0000-0002-3746-9086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8994152547ee4765b1653b834c52a21a.json"}}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ee1510080704cf6a2a6972deb94123f.json"}}], "type": "journal article", "published": "2022-01-13", "journal": {"title": "Nat Genet", "issn": "1546-1718", "issn-l": null}, "abstract": "The OAS1/2/3 cluster has been identified as a risk locus for severe COVID-19 among individuals of European ancestry, with a protective haplotype of approximately 75 kilobases (kb) derived from Neanderthals in the chromosomal region 12q24.13. This haplotype contains a splice variant of OAS1, which occurs in people of African ancestry independently of gene flow from Neanderthals. Using trans-ancestry fine-mapping approaches in 20,779 hospitalized cases, we demonstrate that this splice variant is likely to be the SNP responsible for the association at this locus, thus strongly implicating OAS1 as an effector gene influencing COVID-19 severity.", "doi": "10.1038/s41588-021-00996-8", "pmid": "35027740", "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41588-021-00996-8"}, {"db": "URL", "key": "https://doi.org/10.5281/zenodo.5708333", "description": "https://doi.org/10.5281/zenodo.5708333"}, {"db": "URL", "key": "https://www.covid19hg.org/results/r6/", "description": "https://www.covid19hg.org/results/r6/"}, {"db": "URL", "key": "https://cadd.gs.washington.edu/score", "description": "https://cadd.gs.washington.edu/score"}, {"db": "URL", "key": "https://www.internationalgenome.org/data", "description": "https://www.internationalgenome.org/data"}], "notes": [], "created": "2022-01-16T12:57:33.433Z", "modified": "2022-01-16T13:00:04.033Z"}, {"entity": "publication", "iuid": "0800ea3269874a8fae8604415ed16e3e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0800ea3269874a8fae8604415ed16e3e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0800ea3269874a8fae8604415ed16e3e"}}, "title": "Integrated epi-econ assessment of vaccination.", "authors": [{"family": "Boppart", "given": "Timo", "initials": "T"}, {"family": "Harmenberg", "given": "Karl", "initials": "K"}, {"family": "Krusell", "given": "Per", "initials": "P"}, {"family": "Olsson", "given": "Jonna", "initials": "J"}], "type": "journal article", "published": "2022-01-13", "journal": {"title": "J Econ Dyn Control", "issn": "0165-1889", "pages": "104308", "issn-l": null}, "abstract": "Using an integrated epi-econ model, we compute the value of vaccines for Covid-19, both under a planner's solution and in competitive equilibrium. The specific model, developed in Boppart, Harmenberg, Hassler, Krusell, and Olsson (2021), factors in not just value-of-life aspects along with standard economic variables but also the value of leisure activities that rely on a social component. We find that the societal value of vaccination is large; we estimate that, translated into monetary terms, the value of vaccinating one young individual in the competitive equilibrium is $17,800. Externalities are large: less than half the societal value is internalized by individuals (assuming that they act purely in their self-interest). Finally, behavioral responses are important, with a substantial share of the value of vaccines being attributed to people enjoying more socially-oriented leisure when more people are vaccinated.", "doi": "10.1016/j.jedc.2022.104308", "pmid": "35039700", "labels": {"Category: Health": null, "Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0165-1889(22)00013-6"}, {"db": "pmc", "key": "PMC8755642"}], "notes": [], "created": "2022-01-27T07:36:18.097Z", "modified": "2022-01-27T07:37:59.857Z"}, {"entity": "publication", "iuid": "445906135b7d45e1bf7d39fe5cf4dffd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/445906135b7d45e1bf7d39fe5cf4dffd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/445906135b7d45e1bf7d39fe5cf4dffd"}}, "title": "Daily uplifts during the COVID-19 pandemic: what is considered helpful in everyday life?", "authors": [{"family": "Eklund", "given": "Rakel", "initials": "R"}, {"family": "Bondjers", "given": "Kristina", "initials": "K"}, {"family": "Hensler", "given": "Ida", "initials": "I"}, {"family": "Bragesj\u00f6", "given": "Maria", "initials": "M"}, {"family": "Johannesson", "given": "Kerstin Bergh", "initials": "KB"}, {"family": "Arnberg", "given": "Filip K", "initials": "FK"}, {"family": "Sveen", "given": "Josefin", "initials": "J"}], "type": "journal article", "published": "2022-01-13", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "85", "issn-l": null}, "abstract": "Knowledge of what is uplifting and helpful during pandemics could inform the design of sustainable pandemic recommendations in the future. We have explored individuals' views on helpful and uplifting aspects of everyday life during the coronavirus disease 2019 (COVID-19) pandemic.\n\nParticipants answered a brief, daily survey via text messages during 14 consecutive days in July-August, 2020. The survey included the question: \"During the past 24 hours, is there anything that has made you feel good or helped you in your life?\" We used content analysis to compile responses from 693 participants, who provided 4,490 free-text answers, which resulted in 24 categories subsumed under 7 themes.\n\nPositive aspects during the COVID-19 pandemic primarily related to social interactions, in real life or digitally, with family, friends and others. Other important aspects concerning work, colleagues and maintaining everyday life routines. One theme concerning vacations, going on excursions and being in nature. Leisure and recreation activities, such as hobbies and physical exercise, also emerged as important, as did health-related factors. Bodily sensations, thoughts, feelings and activities that benefited well-being were mentioned frequently. Lastly, people commented on the government strategies for containing COVID-19, and whether to comply with restrictions.\n\nTo summarize, daily uplifts and helpful aspects of everyday life centered around social relationships. To comply with recommendations on physical distancing, people found creative ways to maintain social connections both digitally and face-to-face. Social interaction, maintenance of everyday life routines, hobbies and physical activity appeared to be important for well-being.", "doi": "10.1186/s12889-022-12506-4", "pmid": "35027034", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-022-12506-4"}, {"db": "pmc", "key": "PMC8757393"}], "notes": [], "created": "2022-01-27T08:14:03.975Z", "modified": "2022-01-27T08:14:03.987Z"}, {"entity": "publication", "iuid": "9043e44a6cf04e9a8a14a5d652b177b5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9043e44a6cf04e9a8a14a5d652b177b5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9043e44a6cf04e9a8a14a5d652b177b5"}}, "title": "ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFN\u03b3-driven immunopathology.", "authors": [{"family": "Gawish", "given": "Riem", "initials": "R", "orcid": "0000-0003-4267-2131", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f738be3889746db9270e409da92b2b5.json"}}, {"family": "Starkl", "given": "Philipp", "initials": "P", "orcid": "0000-0001-7521-129X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8877b7b32fe4b20b9ef859ccaff5938.json"}}, {"family": "Pimenov", "given": "Lisabeth", "initials": "L"}, {"family": "Hladik", "given": "Anastasiya", "initials": "A"}, {"family": "Lakovits", "given": "Karin", "initials": "K"}, {"family": "Oberndorfer", "given": "Felicitas", "initials": "F"}, {"family": "Cronin", "given": "Shane Jf", "initials": "SJ"}, {"family": "Ohradanova-Repic", "given": "Anna", "initials": "A", "orcid": "0000-0002-8005-8522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05059e6a105642238652352cc49b5a8b.json"}}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G"}, {"family": "Agerer", "given": "Benedikt", "initials": "B"}, {"family": "Endler", "given": "Lukas", "initials": "L"}, {"family": "Capraz", "given": "T\u00fcmay", "initials": "T"}, {"family": "Perthold", "given": "Jan W", "initials": "JW"}, {"family": "Cikes", "given": "Domagoj", "initials": "D"}, {"family": "Koglgruber", "given": "Rubina", "initials": "R"}, {"family": "Hagelkruys", "given": "Astrid", "initials": "A"}, {"family": "Montserrat", "given": "Nuria", "initials": "N"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Boon", "given": "Louis", "initials": "L"}, {"family": "Stockinger", "given": "Hannes", "initials": "H", "orcid": "0000-0001-6404-4430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/134cb6399ed043879f4f834914429698.json"}}, {"family": "Bergthaler", "given": "Andreas", "initials": "A"}, {"family": "Oostenbrink", "given": "Chris", "initials": "C", "orcid": "0000-0002-4232-2556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37566a0341cf4fd38366e43218cffd23.json"}}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}, {"family": "Knapp", "given": "Sylvia", "initials": "S", "orcid": "0000-0001-9016-5244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81c1b98b50754c84b62f7867c9dc453f.json"}}], "type": "journal article", "published": "2022-01-13", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "11", "issn-l": null}, "abstract": "Despite tremendous progress in the understanding of COVID-19, mechanistic insight into immunological, disease-driving factors remains limited. We generated maVie16, a mouse-adapted SARS-CoV-2, by serial passaging of a human isolate. In silico modeling revealed how only three Spike mutations of maVie16 enhanced interaction with murine ACE2. maVie16 induced profound pathology in BALB/c and C57BL/6 mice, and the resulting mouse COVID-19 (mCOVID-19) replicated critical aspects of human disease, including early lymphopenia, pulmonary immune cell infiltration, pneumonia, and specific adaptive immunity. Inhibition of the proinflammatory cytokines IFN\u03b3 and TNF substantially reduced immunopathology. Importantly, genetic ACE2-deficiency completely prevented mCOVID-19 development. Finally, inhalation therapy with recombinant ACE2 fully protected mice from mCOVID-19, revealing a novel and efficient treatment. Thus, we here present maVie16 as a new tool to model COVID-19 for the discovery of new therapies and show that disease severity is determined by cytokine-driven immunopathology and critically dependent on ACE2 in vivo.", "doi": "10.7554/eLife.74623", "pmid": "35023830", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8776253"}, {"db": "pii", "key": "74623"}], "notes": [], "created": "2022-01-27T08:14:33.232Z", "modified": "2023-06-19T14:37:10.312Z"}, {"entity": "publication", "iuid": "d4dabb16e6ba4d8981a4d7c5fd8d170b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4dabb16e6ba4d8981a4d7c5fd8d170b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4dabb16e6ba4d8981a4d7c5fd8d170b"}}, "title": "SARS-CoV-2 induces a durable and antigen specific humoral immunity after asymptomatic to mild COVID-19 infection", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f28f2f6ac9648629c2d2de92fe7bb59.json"}}, {"family": "Jernbom Falk", "given": "August", "initials": "A", "orcid": "0000-0002-7773-1851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40d944d7fa964f4292f10012356a2730.json"}}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/305bca9e5c6c423898c272bf06ce2f2a.json"}}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Gabrielsson", "given": "Lena", "initials": "L"}, {"family": "Salomonsson", "given": "Ann Christin", "initials": "AC"}, {"family": "Isaksson", "given": "Eva", "initials": "E", "orcid": "0000-0003-0289-8750", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30fe14f786534ff49600d0ef859d30ca.json"}}, {"family": "Rudberg", "given": "Ann Sofie", "initials": "AS"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C", "orcid": "0000-0003-0880-5375", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7394cf1c96945888fc8765568f5407c.json"}}, {"family": "Andersson", "given": "Eni", "initials": "E", "orcid": "0000-0002-5115-0637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8200b399e954f3482aec53a62df3b54.json"}}, {"family": "Olofsson", "given": "Jennie", "initials": "J"}, {"family": "Skoglund", "given": "Lovisa", "initials": "L"}, {"family": "Yousef", "given": "Jamil", "initials": "J", "orcid": "0000-0001-5915-1258", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/324e111715fc4029badd136232057025.json"}}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f2dc27d02294a15a6f691be6aab641f.json"}}, {"family": "Olausson", "given": "Mikaela", "initials": "M"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Tegel", "given": "Hanna", "initials": "H"}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "journal-article", "published": "2022-01-12", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "17", "issue": "1", "pages": "e0262169"}, "abstract": null, "doi": "10.1371/journal.pone.0262169", "pmid": "35020778", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Research Area: Drug discovery and repurposing of drugs": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-01-05T09:43:17.149Z", "modified": "2022-02-14T14:46:43.789Z"}, {"entity": "publication", "iuid": "86bede1137574ee892bfd81d8edfb49c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86bede1137574ee892bfd81d8edfb49c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86bede1137574ee892bfd81d8edfb49c"}}, "title": "Rapid cytokine release assays for analysis of SARS-CoV-2-specific T cells in whole blood.", "authors": [{"family": "T\u00f6rnell", "given": "Andreas", "initials": "A", "orcid": "0000-0003-0769-2815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0e49354b88f4f7c8792dfb4216561c8.json"}}, {"family": "Grauers Wiktorin", "given": "Hanna", "initials": "H"}, {"family": "Ringlander", "given": "Johan", "initials": "J", "orcid": "0000-0002-8483-6504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64f85af7dceb436498422e62f1a98c89.json"}}, {"family": "Arabpour", "given": "Mohammad", "initials": "M"}, {"family": "Nilsson", "given": "Malin R", "initials": "MR"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Kiffin", "given": "Roberta", "initials": "R"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K"}, {"family": "Martner", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899", "volume": null, "issue": null, "pages": null}, "abstract": "Waning of IgG antibodies against SARS-CoV-2 complicates diagnosis of past infection. Durability of T cell memory against SARS-CoV-2 remains unclear, and most current T cell protocols are unsuited for large-scale automation.\r\n\r\nWhole blood samples from 31 patients with verified past COVID-19 and 46 controls, out of which 40 received SARS-CoV-2 vaccine were stimulated with peptides spanning the nucleocapsid (NC) or spike 1 (S1) regions of SARS-CoV-2 and analyzed for interferon-\u03b3 (IFN-\u03b3) in supernatant plasma. Diagnostic accuracy of these assays was evaluated against serum anti-NC and anti-receptor-binding domain S1 IgG.\r\n\r\nInduction of IFN-\u03b3 in whole blood by NC or S1 peptides diagnosed past COVID-19 with high accuracy (AUC=0.93, AUC=0.95, respectively). In accordance with previous studies, NC-IgG levels rapidly waned with only 5/17 patients (29%) remaining seropositive >180 days after infection. By contrast, NC-peptide-induced T cell memory responses remained in 13/17 (76%) subjects >180 days after infection (P=0.012 vs. NC-IgG, McNemar test). After two vaccine doses, 18/18 donors exhibited S1-specific T cell memory.\r\n\r\nCytokine release assays for the monitoring of T cell memory in whole blood may be useful for evaluation of complications following unverified past COVID-19 and for long-term assessment of vaccine-induced T cell immunity.", "doi": "10.1093/infdis/jiac005", "pmid": "35022764", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "6504009"}], "notes": [], "created": "2022-01-13T20:54:06.771Z", "modified": "2022-01-27T08:16:10.671Z"}, {"entity": "publication", "iuid": "1ebcd2295d00429aad5aa2b70d0e4584", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ebcd2295d00429aad5aa2b70d0e4584.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ebcd2295d00429aad5aa2b70d0e4584"}}, "title": "Melflufen or pomalidomide plus dexamethasone for patients with multiple myeloma refractory to lenalidomide (OCEAN): a randomised, head-to-head, open-label, phase 3 study.", "authors": [{"family": "Schjesvold", "given": "Fredrik H", "initials": "FH"}, {"family": "Dimopoulos", "given": "Meletios-Athanasios", "initials": "MA"}, {"family": "Delimpasi", "given": "Sosana", "initials": "S"}, {"family": "Robak", "given": "Pawel", "initials": "P"}, {"family": "Coriu", "given": "Daniel", "initials": "D"}, {"family": "Legiec", "given": "Wojciech", "initials": "W"}, {"family": "Pour", "given": "Lud\u011bk", "initials": "L"}, {"family": "\u0160pi\u010dka", "given": "Ivan", "initials": "I"}, {"family": "Masszi", "given": "Tamas", "initials": "T"}, {"family": "Doronin", "given": "Vadim", "initials": "V"}, {"family": "Minarik", "given": "Jiri", "initials": "J"}, {"family": "Salogub", "given": "Galina", "initials": "G"}, {"family": "Alekseeva", "given": "Yulia", "initials": "Y"}, {"family": "Lazzaro", "given": "Antonio", "initials": "A"}, {"family": "Maisnar", "given": "Vladimir", "initials": "V"}, {"family": "Mikala", "given": "G\u00e1bor", "initials": "G"}, {"family": "Rosi\u00f1ol", "given": "Laura", "initials": "L"}, {"family": "Liberati", "given": "Anna Marina", "initials": "AM"}, {"family": "Symeonidis", "given": "Argiris", "initials": "A"}, {"family": "Moody", "given": "Victoria", "initials": "V"}, {"family": "Thuresson", "given": "Marcus", "initials": "M"}, {"family": "Byrne", "given": "Catriona", "initials": "C"}, {"family": "Harmenberg", "given": "Johan", "initials": "J"}, {"family": "Bakker", "given": "Nicolaas A", "initials": "NA"}, {"family": "H\u00e1jek", "given": "Roman", "initials": "R"}, {"family": "Mateos", "given": "Maria-Victoria", "initials": "MV"}, {"family": "Richardson", "given": "Paul G", "initials": "PG"}, {"family": "Sonneveld", "given": "Pieter", "initials": "P"}, {"family": "OCEAN (OP-103) Investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "Lancet Haematol", "issn": "2352-3026", "issn-l": null}, "abstract": "Melphalan flufenamide (melflufen), an alkylating peptide-drug conjugate, plus dexamethasone showed clinical activity and manageable safety in the phase 2 HORIZON study. We aimed to determine whether melflufen plus dexamethasone would provide a progression-free survival benefit compared with pomalidomide plus dexamethasone in patients with previously treated multiple myeloma.\n\nIn this randomised, open-label, head-to-head, phase 3 study (OCEAN), adult patients (aged \u226518 years) were recruited from 108 university hospitals, specialist hospitals, and community-based centres in 21 countries across Europe, North America, and Asia. Eligible patients had an ECOG performance status of 0-2; must have had relapsed or refractory multiple myeloma, refractory to lenalidomide (within 18 months of randomisation) and to the last line of therapy; and have received two to four previous lines of therapy (including lenalidomide and a proteasome inhibitor). Patients were randomly assigned (1:1), stratified by age, number of previous lines of therapy, and International Staging System score, to either 28-day cycles of melflufen and dexamethasone (melflufen group) or pomalidomide and dexamethasone (pomalidomide group). All patients received dexamethasone 40 mg orally on days 1, 8, 15, and 22 of each cycle. In the melflufen group, patients received melflufen 40 mg intravenously over 30 min on day 1 of each cycle and in the pomalidomide group, patients received pomalidomide 4 mg orally daily on days 1 to 21 of each cycle. The primary endpoint was progression-free survival assessed by an independent review committee in the intention-to-treat (ITT) population. Safety was assessed in patients who received at least one dose of study medication. This study is registered with ClinicalTrials.gov, NCT03151811, and is ongoing.\n\nBetween June 12, 2017, and Sept 3, 2020, 246 patients were randomly assigned to the melflufen group (median age 68 years [IQR 60-72]; 107 [43%] were female) and 249 to the pomalidomide group (median age 68 years [IQR 61-72]; 109 [44%] were female). 474 patients received at least one dose of study drug (melflufen group n=228; pomalidomide group n=246; safety population). Data cutoff was Feb 3, 2021. Median progression-free survival was 6\u00b78 months (95% CI 5\u00b70-8\u00b75; 165 [67%] of 246 patients had an event) in the melflufen group and 4\u00b79 months (4\u00b72-5\u00b77; 190 [76%] of 249 patients had an event) in the pomalidomide group (hazard ratio [HR] 0\u00b779, [95% CI 0\u00b764-0\u00b798]; p=0\u00b7032), at a median follow-up of 15\u00b75 months (IQR 9\u00b74-22\u00b78) in the melflufen group and 16\u00b73 months (10\u00b71-23\u00b72) in the pomalidomide group. Median overall survival was 19\u00b78 months (95% CI 15\u00b71-25\u00b76) at a median follow-up of 19\u00b78 months (IQR 12\u00b70-25\u00b70) in the melflufen group and 25\u00b70 months (95% CI 18\u00b71-31\u00b79) in the pomalidomide group at a median follow-up of 18\u00b76 months (IQR 11\u00b78-23\u00b77; HR 1\u00b710 [95% CI 0\u00b785-1\u00b744]; p=0\u00b747). The most common grade 3 or 4 treatment-emergent adverse events were thrombocytopenia (143 [63%] of 228 in the melflufen group vs 26 [11%] of 246 in the pomalidomide group), neutropenia (123 [54%] vs 102 [41%]), and anaemia (97 [43%] vs 44 [18%]). Serious treatment-emergent adverse events occurred in 95 (42%) patients in the melflufen group and 113 (46%) in the pomalidomide group, the most common of which were pneumonia (13 [6%] vs 21 [9%]), COVID-19 pneumonia (11 [5%] vs nine [4%]), and thrombocytopenia (nine [4%] vs three [1%]). 27 [12%] patients in the melflufen group and 32 [13%] in the pomalidomide group had fatal treatment-emergent adverse events. Fatal treatment-emergent adverse events were considered possibly treatment related in two patients in the melflufen group (one with acute myeloid leukaemia, one with pancytopenia and acute cardiac failure) and four patients in the pomalidomide group (two patients with pneumonia, one with myelodysplastic syndromes, one with COVID-19 pneumonia).\n\nMelflufen plus dexamethasone showed superior progression-free survival than pomalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma.\n\nOncopeptides AB.", "doi": "10.1016/S2352-3026(21)00381-1", "pmid": "35032434", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2352-3026(21)00381-1"}, {"db": "ClinicalTrials.gov", "key": "NCT03151811"}], "notes": [], "created": "2022-01-27T08:01:51.013Z", "modified": "2022-01-27T08:02:32.941Z"}, {"entity": "publication", "iuid": "39bc0b2add3e4b35a4e165267c32aebd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/39bc0b2add3e4b35a4e165267c32aebd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/39bc0b2add3e4b35a4e165267c32aebd"}}, "title": "Hospital Admissions for Respiratory Tract Infections in Children Aged 0-5 Years for 2017/2023.", "authors": [{"family": "Methi", "given": "Fredrik", "initials": "F"}, {"family": "St\u00f8rdal", "given": "Ketil", "initials": "K"}, {"family": "Telle", "given": "Kjetil", "initials": "K"}, {"family": "Larsen", "given": "Vilde Bergstad", "initials": "VB"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "Front Pediatr", "issn": "2296-2360", "volume": "9", "pages": "822985", "issn-l": "2296-2360"}, "abstract": "Aim: To compare hospital admissions across common respiratory tract infections (RTI) in 2017-21, and project possible hospital admissions for the RTIs among children aged 0-12 months and 1-5 years in 2022 and 2023. Methods: In 644 885 children aged 0-12 months and 1-5 years, we plotted the observed monthly number of RTI admissions [upper- and lower RTI, influenza, respiratory syncytial virus (RSV), and COVID-19] from January 1st, 2017 until October 31st, 2021. We also plotted the number of RTI admissions with a need for respiratory support. We used the observed data to project four different scenarios of RTI admissions for the rest of 2021 until 2023, with different impacts on hospital wards: (1) \"Business as usual,\" (2) \"Continuous lockdown,\" (3) \"Children's immunity debt,\" and (4) \"Maternal and child immunity debt.\" Results: By October 31st, 2021, the number of simultaneous RTI admissions had exceeded the numbers usually observed at the typical season peak in January, i.e., ~900. Based on our observed data and assuming that children and their mothers (who transfer antibodies to the very youngest) have not been exposed to RTI over the last one and a half years, our scenarios suggest that hospitals should be prepared to handle two to three times as many RTI admissions, and two to three times as many RTI admissions requiring respiratory support among 0-5-year-olds as normal, from November 2021 to April 2022. Conclusion: Scenarios with immunity debt suggest that pediatric hospital wards and policy makers should plan for extended capacity.", "doi": "10.3389/fped.2021.822985", "pmid": "35096720", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8790534"}], "notes": [], "created": "2022-02-06T16:56:19.763Z", "modified": "2022-02-06T16:56:19.769Z"}, {"entity": "publication", "iuid": "4c9b95143255486b93902708459647f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4c9b95143255486b93902708459647f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4c9b95143255486b93902708459647f0"}}, "title": "Health care utilization following \"digi-physical\" assessment compared to physical assessment for infectious symptoms in primary care.", "authors": [{"family": "Entezarjou", "given": "Artin", "initials": "A"}, {"family": "Sj\u00f6beck", "given": "Maria", "initials": "M"}, {"family": "Midl\u00f6v", "given": "Patrik", "initials": "P"}, {"family": "Nymberg", "given": "Veronica Milos", "initials": "VM"}, {"family": "Vigren", "given": "Lina", "initials": "L"}, {"family": "Labaf", "given": "Ashkan", "initials": "A"}, {"family": "Jakobsson", "given": "Ulf", "initials": "U"}, {"family": "Calling", "given": "Susanna", "initials": "S"}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "BMC Prim Care", "issn": "2731-4553", "volume": "23", "pages": "4", "issn-l": null}, "abstract": "The use of chat-based digital visits (eVisits) to assess infectious symptoms in primary care is rapidly increasing. The \"digi-physical\" model of care uses eVisits as the first line of assessment while assuming a certain proportion of patients will inevitably need to be further assessed through urgent physical examination within 48 h. It is unclear to what extent this approach can mitigate physical visits compared to assessing patients directly using office visits.\n\nThis pre-COVID-19-pandemic observational study followed up \"digi-physical\" eVisit patients (n = 1188) compared to office visit patients (n = 599) with respiratory or urinary symptoms. Index visits occurred between March 30th 2016 and March 29th 2019. The primary outcome was subsequent physical visits to physicians within two weeks using registry data from Sk\u00e5ne county, Sweden (Region Sk\u00e5nes V\u00e5rddatabas, RSVD).\n\nNo significant differences in subsequent physical visits within two weeks (excluding the first 48 h) were noted following \"digi-physical\" care compared to office visits (179 (18.0%) vs. 102 (17.6%), P = .854). As part of the \"digital-physical\" concept, a significantly larger proportion of eVisit patients had a physical visit within 48 h compared to corresponding office visit patients (191 (16.1%) vs. 19 (3.2%), P < .001), with 150 (78.5%) of these eVisit patients recommended some form of follow-up by the eVisit physician.\n\nMost eVisit patients (68.9%) with respiratory and urinary symptoms have no subsequent physical visits. Beyond an unavoidable portion of patients requiring urgent physical examination within 48 h, \"digi-physical\" management of respiratory and urinary symptoms results in comparable subsequent health care utilization compared to office visits. eVisit providers may need to optimize use of resources to minimize the proportion of patients being assessed both digitally and physically within 48 h as part of the \"digi-physical\" concept.\n\nClinicaltrials.gov identifier: NCT03474887.\n\nThe online version contains supplementary material available at 10.1186/s12875-021-01618-2.", "doi": "10.1186/s12875-021-01618-2", "pmid": "35036998", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "1618"}, {"db": "pmc", "key": "PMC8753946"}, {"db": "ClinicalTrials.gov", "key": "NCT03474887"}], "notes": [], "created": "2022-01-27T07:38:39.967Z", "modified": "2022-01-27T07:38:40.002Z"}, {"entity": "publication", "iuid": "ec5b43c5579b48b993c1bde3ea0b43f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec5b43c5579b48b993c1bde3ea0b43f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec5b43c5579b48b993c1bde3ea0b43f1"}}, "title": "Europe must come together to confront omicron.", "authors": [{"family": "Health professionals and researchers from across Europe", "given": "", "initials": ""}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "376", "pages": "o90", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.o90", "pmid": "35027352", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2022-01-27T08:04:55.333Z", "modified": "2022-01-27T08:05:01.654Z"}, {"entity": "publication", "iuid": "ece53f8821f84bd69158ea993ccbb0ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ece53f8821f84bd69158ea993ccbb0ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ece53f8821f84bd69158ea993ccbb0ff"}}, "title": "Childhood cancer survivorship care during the COVID-19 pandemic: an international report of practice implications and provider concerns.", "authors": [{"family": "van den Oever", "given": "Selina R", "initials": "SR"}, {"family": "Pluijm", "given": "Saskia M F", "initials": "SMF"}, {"family": "Skinner", "given": "Rod", "initials": "R"}, {"family": "Glaser", "given": "Adam", "initials": "A"}, {"family": "Mulder", "given": "Ren\u00e9e L", "initials": "RL"}, {"family": "Armenian", "given": "Saro", "initials": "S"}, {"family": "Bardi", "given": "Edit", "initials": "E"}, {"family": "Berger", "given": "Claire", "initials": "C"}, {"family": "Ehrhardt", "given": "Matthew J", "initials": "MJ"}, {"family": "Gilleland Marchak", "given": "Jordan", "initials": "J"}, {"family": "Haeusler", "given": "Gabrielle M", "initials": "GM"}, {"family": "Hartogh", "given": "Jaap den", "initials": "JD"}, {"family": "Hjorth", "given": "Lars", "initials": "L"}, {"family": "Kepak", "given": "Tomas", "initials": "T"}, {"family": "Kriviene", "given": "Izolda", "initials": "I"}, {"family": "Langer", "given": "Thorsten", "initials": "T"}, {"family": "Maeda", "given": "Miho", "initials": "M"}, {"family": "M\u00e1rquez-Vega", "given": "Catalina", "initials": "C"}, {"family": "Michel", "given": "Gisela", "initials": "G"}, {"family": "Muraca", "given": "Monica", "initials": "M"}, {"family": "Najib", "given": "Mohamed", "initials": "M"}, {"family": "Nathan", "given": "Paul C", "initials": "PC"}, {"family": "Panasiuk", "given": "Anna", "initials": "A"}, {"family": "Prasad", "given": "Maya", "initials": "M"}, {"family": "Roganovic", "given": "Jelena", "initials": "J"}, {"family": "Uyttebroeck", "given": "Anne", "initials": "A"}, {"family": "Winther", "given": "Jeanette F", "initials": "JF"}, {"family": "Zadravec Zaletel", "given": "Lorna", "initials": "L"}, {"family": "van Dalen", "given": "Elvira C", "initials": "EC"}, {"family": "van der Pal", "given": "Helena J H", "initials": "HJH"}, {"family": "Hudson", "given": "Melissa M", "initials": "MM"}, {"family": "Kremer", "given": "Leontien C M", "initials": "LCM"}, {"family": "IGHG COVID-19 working group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "J Cancer Surviv", "issn": "1932-2267", "issn-l": null}, "abstract": "Long-term follow-up (LTFU) care is essential to optimise health outcomes in childhood cancer survivors (CCS). We aimed to assess the impact of the COVID-19 pandemic on LTFU services and providers.\n\nA COVID-19 working group within the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) distributed a questionnaire to LTFU service providers in 37 countries across Europe, Asia, North America, Central/South America, and Australia. The questionnaire assessed how care delivery methods changed during the pandemic and respondents' level of worry about the pandemic's impact on LTFU care delivery, their finances, their health, and that of their family and friends.\n\nAmong 226 institutions, providers from 178 (79%) responded. Shortly after the initial outbreak, 42% of LTFU clinics closed. Restrictions during the pandemic resulted in fewer in-person consultations and an increased use of telemedicine, telephone, and email consultations. The use of a risk assessment to prioritise the method of LTFU consultation for individual CCS increased from 12 to 47%. While respondents anticipated in-person consultations to remain the primary method for LTFU service delivery, they expected significantly increased use of telemedicine and telephone consultations after the pandemic. On average, respondents reported highest levels of worry about psychosocial well-being of survivors.\n\nThe pandemic necessitated changes in LTFU service delivery, including greater use of virtual LTFU care and risk-stratification to identify CCS that need in-person evaluations.\n\nIncreased utilisation of virtual LTFU care and risk stratification is likely to persist post-pandemic.", "doi": "10.1007/s11764-021-01120-9", "pmid": "35020136", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11764-021-01120-9"}], "notes": [], "created": "2022-01-13T20:59:59.684Z", "modified": "2022-01-13T20:59:59.713Z"}, {"entity": "publication", "iuid": "0adb863d25c64639a287d0914a64f96c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0adb863d25c64639a287d0914a64f96c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0adb863d25c64639a287d0914a64f96c"}}, "title": "BMI in early adulthood is associated with severe COVID-19 later in life - a prospective cohort study of 1.5 million Swedish men.", "authors": [{"family": "Robertson", "given": "Josefina", "initials": "J", "orcid": "0000-0002-2167-6822", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b16ed75f7eb4950beacd818fe23d5e5.json"}}, {"family": "Adiels", "given": "Martin", "initials": "M"}, {"family": "Lissner", "given": "Lauren", "initials": "L"}, {"family": "Mehlig", "given": "Kirsten", "initials": "K"}, {"family": "Af Geijerstam", "given": "Agnes", "initials": "A"}, {"family": "Lindgren", "given": "Martin", "initials": "M"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Ekblom Bak", "given": "Elin", "initials": "E"}, {"family": "Rosengren", "given": "Annika", "initials": "A"}, {"family": "\u00c5berg", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "Obesity (Silver Spring)", "issn": "1930-739X", "issn-l": null}, "abstract": "Overweight and obesity have been identified as risk factors for severe COVID-19, however, prospective cohort studies investigating the association between overweight early in life and severity of COVID-19 are lacking.\n\nWe included 1,551,670 Swedish men, born 1950-1987, with body mass index (BMI) registered at age 18. They were followed until January 9, 2021. COVID-19 cases and comorbidities were identified through the National Patient, Intensive Care, and Cause of Death registries. Outcomes were: 1) hospitalization, 2) intensive care unit admission, and 3) death.\n\nWe found 4,315 cases (mean age 56.4 years, SD 8.8) hospitalized due to COVID-19, of which 729 were admitted to an intensive care unit, and altogether 224 deaths. The risk for hospital admission increased with higher values of BMI (kg/m2 ), despite adjustment for comorbidities, from odds ratio (OR) 1.19 (95% CI 1.08-1.31) at BMI 22.5-25 to 1.68 (1.39-2.02) at BMI \u226530 compared to BMI 18.5-20. ORs for intensive care unit admission were 1.44 (1.13-1.84) at BMI 22.5-25 and 2.61 (1.73-3.93) at BMI \u226530.\n\nHigher BMI in early adulthood was associated with severe COVID-19 many years later with a risk increase starting already at BMI \u226522.5. This underlines the necessity of preventive actions against overweight in youth to offer protection against coming viral pandemics.", "doi": "10.1002/oby.23378", "pmid": "35023305", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-01-13T20:53:28.070Z", "modified": "2022-01-27T08:15:25.788Z"}, {"entity": "publication", "iuid": "b9613c0c5cab4be28151d60193f28d1c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9613c0c5cab4be28151d60193f28d1c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9613c0c5cab4be28151d60193f28d1c"}}, "title": "A first remotely-delivered guided brief intervention to reduce intrusive memories of psychological trauma for healthcare staff working during the ongoing COVID-19 pandemic: Study protocol for a randomised controlled trial.", "authors": [{"family": "Singh", "given": "Laura", "initials": "L"}, {"family": "Kanstrup", "given": "Marie", "initials": "M"}, {"family": "Gamble", "given": "Beau", "initials": "B"}, {"family": "Geranmayeh", "given": "Anahita", "initials": "A"}, {"family": "G\u00f6ransson", "given": "Katarina E", "initials": "KE"}, {"family": "Rudman", "given": "Ann", "initials": "A"}, {"family": "Dahl", "given": "Oili", "initials": "O"}, {"family": "Lindstr\u00f6m", "given": "Veronica", "initials": "V"}, {"family": "H\u00f6rberg", "given": "Anna", "initials": "A"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}, {"family": "Moulds", "given": "Michelle L", "initials": "ML"}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "Contemp Clin Trials Commun", "issn": "2451-8654", "pages": "100884", "issn-l": null}, "abstract": "Addressing the mental health needs of healthcare staff exposed to psychologically traumatic events at work during the COVID-19 pandemic is a pressing global priority. We need to swiftly develop interventions to target the psychological consequences (e.g., persistent intrusive memories of trauma). Interventions for healthcare staff must be brief, flexible, fitted around the reality and demands of working life under the pandemic, and repeatable during ongoing/further trauma exposure. Intervention delivery during the pandemic should be remote to mitigate risk of infection; e.g., here using a blend of digitalized self-administered materials (e.g., video instructions) and guided (remote) support from a researcher. This parallel groups, two-arm, randomised controlled trial (RCT) with healthcare staff working during the COVID-19 pandemic is the first evaluation of whether a digitalized form of a brief cognitive task intervention, which is remotely-delivered (guided), reduces intrusive memories. Healthcare staff (target N = 130 completers) who experience intrusive memories of work-related traumatic event(s) during the COVID-19 pandemic (\u22652 in the week before inclusion) will be randomly allocated (1:1) to receive either the cognitive task intervention or an active (attention placebo) control, and followed up at 1-week, 1-month, 3-months, and 6-months post-intervention. The primary outcome will be the number of intrusive memories reported during Week 5; secondary and other outcomes include the number of intrusive memories reported during Week 1, and other intrusive symptoms. Findings will inform further development and dissemination of a brief cognitive task intervention to target intrusive memories.", "doi": "10.1016/j.conctc.2022.100884", "pmid": "35036626", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2451-8654(22)00001-1"}, {"db": "pmc", "key": "PMC8752164"}], "notes": [], "created": "2022-01-27T07:39:12.779Z", "modified": "2022-01-27T07:39:12.815Z"}, {"entity": "publication", "iuid": "15ab40122fc94d8b978a421f3b54face", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15ab40122fc94d8b978a421f3b54face.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15ab40122fc94d8b978a421f3b54face"}}, "title": "The local and global mental health effects of the Covid-19 pandemic.", "authors": [{"family": "Akay", "given": "Alpaslan", "initials": "A"}], "type": "journal article", "published": "2022-01-11", "journal": {"title": "Econ Hum Biol", "issn": "1873-6130", "volume": "45", "pages": "101095", "issn-l": null}, "abstract": "This paper investigates the mental health effects of the local and global level Covid-19 pandemic among the UK population. To identify the effect, we use a high-quality dataset and an original strategy where we match the previous day's confirmed pandemic cases to a four-month panel of individual mental health information observed during the interview next day. The approach suggested in this paper aims to identify the average mental health effect on the overall population for the first and second waves of the pandemic. Using a linear fixed-effects model specification, we report robust findings that the average mental health in the UK is substantially reduced by the local and global pandemic. The total reduction in the average mental health of the UK population during our sampling period (April - June, 2020) is about 1.5% for the local and 2.4% for the global cases, which sum up to a 3.9% reduction. Extrapolating the total reduction in average mental health during the first wave of the pandemic (February - September, 2020) sums up to 2.8% while the effect is as large as 9.6% for the first and second waves together, which covers roughly a year since the start. An extensive robustness check suggests that the findings are stable with respect to alternative pandemic datasets, measures, estimators, functional forms, and time functions. The characteristics of the most vulnerable individuals (e.g., elderly, chronic illness, and job security concerns) and their household conditions (e.g., living alone and no private space) are explored. The paper discusses on the implications of the results.", "doi": "10.1016/j.ehb.2021.101095", "pmid": "35092869", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1570-677X(21)00120-9"}, {"db": "pmc", "key": "PMC8750697"}], "notes": [], "created": "2022-01-31T11:40:41.594Z", "modified": "2022-02-06T17:07:27.067Z"}, {"entity": "publication", "iuid": "257c8ebf09e843069de1b8dda587e433", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/257c8ebf09e843069de1b8dda587e433.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/257c8ebf09e843069de1b8dda587e433"}}, "title": "Swallowing function in COVID-19 patients after invasive mechanical ventilation.", "authors": [{"family": "Lindh", "given": "Margareta Gonzalez", "initials": "MG"}, {"family": "Mattsson", "given": "Gustav", "initials": "G"}, {"family": "Koyi", "given": "Hirsh", "initials": "H"}, {"family": "Johansson", "given": "Monica Blom", "initials": "MB"}, {"family": "Razmi", "given": "Robin", "initials": "R"}, {"family": "Palm", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2022-01-11", "journal": {"title": "Arch Rehabil Res Clin Transl", "issn": "2590-1095", "pages": "100177", "issn-l": null}, "abstract": "To explore swallowing function and risk factors associated with delayed recovery of swallowing in COVID-19 patients post invasive mechanical ventilation using the Functional Oral Intake Scale (FOIS).\n\nLongitudinal cohort study.\n\n3 secondary-level hospitals.\n\nInvasively ventilated patients (n=28), hospitalized with severe COVID-19 who were referred to the Speech and Language Pathology (SLP) departments post mechanical ventilation between March 5 and July 5 2020 for an evaluation of swallowing function before commencing oral diet.\n\nSLP assessment, advice and therapy for dysphagia.\n\nOral intake levels at baseline and hospital discharge according to the Functional Oral Intake Scale (FOIS). Patients were stratified according to FOIS (1-5=dysphagia, 6-7= functional oral intake). Data regarding comorbidities, frailty, intubation and tracheostomy, proning and SLP evaluation were collected.\n\nDysphagia was found in 71% of the patients at baseline (in total 79% male, age 61 \u00b112 years, BMI 30 \u00b18 kg/m2). Median FOIS score at baseline was 2 (IQR 1) vs 5 (IQR 2.5) at hospital discharge. Patients with dysphagia were older (64 \u00b18.5 vs 53 \u00b116 years; p= 0.019), had a higher incidence of hypertension (70% vs 12%; p=0.006) were ventilated invasively longer (16 \u00b17 vs 10 \u00b12 days; p=0.017) or with tracheostomy (9 \u00b19 vs 1 \u00b12 days; p=0.03) longer. A negative association was found between swallowing dysfunction at bedside and days hospitalized (r=-0.471, p=0.01), and number of days at the Intensive Care Unit (ICU) (r=-0.48, p=0.01).\n\nDysphagia is prevalent in COVID-19 patients post invasive mechanical ventilation and is associated with number of days in hospital and number of days in the ICU. Swallowing function and tolerance of oral diet improved at discharge (p<0.001).", "doi": "10.1016/j.arrct.2021.100177", "pmid": "35036903", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2590-1095(21)00093-8"}, {"db": "pmc", "key": "PMC8748224"}], "notes": [], "created": "2022-01-27T07:38:50.922Z", "modified": "2022-01-27T07:38:50.958Z"}, {"entity": "publication", "iuid": "15da31ac86004e92b1ec0cb6dae07880", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15da31ac86004e92b1ec0cb6dae07880.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15da31ac86004e92b1ec0cb6dae07880"}}, "title": "Preclinical evaluation of [11C]GW457427 as a tracer for neutrophil elastase.", "authors": [{"family": "Estrada", "given": "Sergio", "initials": "S"}, {"family": "Elgland", "given": "Mathias", "initials": "M"}, {"family": "Selvaraju", "given": "Ram Kumar", "initials": "RK"}, {"family": "Mani", "given": "Kevin", "initials": "K"}, {"family": "Tegler", "given": "Gustaf", "initials": "G"}, {"family": "Wanhainen", "given": "Anders", "initials": "A"}, {"family": "W\u00e5gs\u00e4ter", "given": "Dick", "initials": "D"}, {"family": "Bergstr\u00f6m", "given": "Mats", "initials": "M"}, {"family": "Jimenez-Royo", "given": "Pilar", "initials": "P"}, {"family": "Jahan", "given": "Mahabuba", "initials": "M"}, {"family": "Nordeman", "given": "Patrik", "initials": "P"}, {"family": "Antoni", "given": "Gunnar", "initials": "G"}], "type": "journal article", "published": "2022-01-11", "journal": {"title": "Nucl Med Biol", "issn": "1872-9614", "volume": "106-107", "pages": "62-71", "issn-l": null}, "abstract": "Neutrophils are part of the innate immune system and function as a first line of defense against invading microorganisms. Overactivity of the immune system may result in a devastating immuno-inflammation with extensive damage to tissue leading to organ damage and/or failure. The literature suggests several human diseases in which neutrophil elastase (NE) is postulated to be important in the pathophysiology including inflammatory bowel disease (IBD), chronic obstructive pulmonary disorder (COPD), abdominal aortic aneurysms (AAA), breast and lung cancer, and recently also in Sars-cov-2 virus infection (Covid-19). In particular, the lungs are affected by the destructive power of the protease neutrophil elastase (NE). In this paper, we report the pre-clinical development of a selective and specific positron emission tomography (PET) tracer, [11C]GW457427, as an in vivo biomarker for the study of NE, now available for human studies.\n\n[11C]GW457427 was produced by methylation of GW447631 using [11C]methyl triflate and GMP validated production and quality control methods were developed. Chemical purity was high with no traces of the precursor GW611437 or other uv-absorbing compounds. A method for the determination of intact [11C]GW457427 in plasma was developed and the binding characteristics were evaluated in vitro and in vivo. An animal model for lung inflammation was used to investigate the specificity and sensitivity of the [11C]GW457427 tracer for neutrophil elastase (NE) in pulmonary inflammation, verified by blockade using two structurally different elastase inhibitors.\n\n[11C]GW457427 was obtained in approximately 45% radiochemical yield and with a radiochemical purity higher than 98%. Molar activity was in the range 130-360 GBq/\u03bcmol. Binding to NE was shown to be highly specific both in vitro and in vivo and a significantly higher uptake of tracer was found in a lipopolysaccharide mouse model of pulmonary inflammation compared with control animals. The uptake in lung tissue measured as standardized uptake value (SUV) strongly correlated with tissue NE content as measured by ELISA. In vitro studies also showed specific tracer binding in aortic tissue of patients with abdominal aorta aneurysm (AAA). The rate of metabolism in rats was appropriate considering the critical balance between available tracer for binding and requirement for blood clearance with about 40% and 20% intact [11C]GW457427 in plasma at 5 and 40 min, respectively. Radioactivity was cleared from blood and organs in control animals with mainly hepatobiliary excretion with distribution in the intestines and the urinary bladder; but without retention of the tracer in healthy organs of interests such as the lung, liver, kidneys or in the cardiovascular system. A dosimetry study in rat indicated that the whole-body effective dose was 2.2 \u03bcSv/MBq with bone marrow as the limiting organ. It is estimated that up to five PET-CT investigations could be performed in humans without exceeding a total dose of 10 mSv.\n\n[11C]GW457427 is a promising in vivo PET-biomarker for NE with high specific binding demonstrated both in vitro and in vivo. A GMP validated production method including quality control has been developed and a microdosing toxicity study performed with no adverse signs. [11C]GW457427 is currently being evaluated in a First-In-Man PET study.", "doi": "10.1016/j.nucmedbio.2022.01.001", "pmid": "35066391", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0969-8051(22)00001-4"}], "notes": [], "created": "2022-01-26T10:17:17.214Z", "modified": "2022-01-26T10:17:17.250Z"}, {"entity": "publication", "iuid": "ed70688f95074af8a1fea26b7f1e2959", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed70688f95074af8a1fea26b7f1e2959.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed70688f95074af8a1fea26b7f1e2959"}}, "title": "Nordic responses to covid-19 from a health promotion perspective.", "authors": [{"family": "Thualagant", "given": "Nicole", "initials": "N", "orcid": "0000-0002-5197-8979", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d68eb2cd38d64995bb48f0354726c6fd.json"}}, {"family": "Simonsen", "given": "Nina", "initials": "N", "orcid": "0000-0003-1376-7588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/862fdf76669f44b7b1ddea945c3a5953.json"}}, {"family": "Sarvim\u00e4ki", "given": "Anneli", "initials": "A"}, {"family": "Stenbock-Hult", "given": "Bettina", "initials": "B"}, {"family": "Olafsdottir", "given": "Helga S", "initials": "HS"}, {"family": "Fosse", "given": "Elisabeth", "initials": "E"}, {"family": "Torp", "given": "Steffen", "initials": "S"}, {"family": "Ringsberg", "given": "Karin C", "initials": "KC"}, {"family": "Forrinder", "given": "Ulla", "initials": "U"}, {"family": "Tillgren", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2022-01-11", "journal": {"issn": "1460-2245", "title": "Health Promot Int", "issn-l": null}, "abstract": "On 30 January 2020, the disease covid-19 was declared by the World Health Organization to be an international threat to human health and on 11 March 2020, the outbreak was declared a pandemic. The aim of this study was to analyse policy strategies developed by the five Nordic countries during the first 3 months of the pandemic from a health promotion perspective in order to identify Nordic responses to the crisis. Although the Nordic countries have a long tradition of co-operation as well as similar social welfare policies and legislation, each country developed their own strategies towards the crisis. The strategies identified were analysed from a health promotion perspective emanating from five principles: intersectorality, sustainability, equity, empowerment and a lifecourse perspective. Denmark, Finland and Norway had lockdowns to varying degrees, whereas Sweden and Iceland had no lockdowns. Iceland implemented a test and tracking strategy from the very beginning. All countries based their recommendations and restrictions on appeals to solidarity and trust in institutions and fellow citizens. The analysis showed that the strategies in all countries could be related to health promotion principles with some differences between the countries especially regarding equity and sustainability. The Nordic governments took responsibility for protecting their citizens by developing policy strategies based on restrictions and recommendations congruent with the principles of health promotion. The findings also identified issues that will pose challenges for future pandemic strategies.", "doi": "10.1093/heapro/daab211", "pmid": "35022714", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6503709"}], "notes": [], "created": "2022-01-13T20:54:40.485Z", "modified": "2022-01-27T08:16:28.127Z"}, {"entity": "publication", "iuid": "8dff9cc6d4b04c53ac781df81a4b0ac9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8dff9cc6d4b04c53ac781df81a4b0ac9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8dff9cc6d4b04c53ac781df81a4b0ac9"}}, "title": "Lessons from COVID-19 for managing transboundary climate risks and building resilience.", "authors": [{"family": "Ringsmuth", "given": "Andrew K", "initials": "AK"}, {"family": "Otto", "given": "Ilona M", "initials": "IM"}, {"family": "van den Hurk", "given": "Bart", "initials": "B"}, {"family": "Lahn", "given": "Glada", "initials": "G"}, {"family": "Reyer", "given": "Christopher P O", "initials": "CPO"}, {"family": "Carter", "given": "Timothy R", "initials": "TR"}, {"family": "Magnuszewski", "given": "Piotr", "initials": "P"}, {"family": "Monasterolo", "given": "Irene", "initials": "I"}, {"family": "Aerts", "given": "Jeroen C J H", "initials": "JCJH"}, {"family": "Benzie", "given": "Magnus", "initials": "M"}, {"family": "Campiglio", "given": "Emanuele", "initials": "E"}, {"family": "Fronzek", "given": "Stefan", "initials": "S"}, {"family": "Gaupp", "given": "Franziska", "initials": "F"}, {"family": "Jarzabek", "given": "Lukasz", "initials": "L"}, {"family": "Klein", "given": "Richard J T", "initials": "RJT"}, {"family": "Knaepen", "given": "Hanne", "initials": "H"}, {"family": "Mechler", "given": "Reinhard", "initials": "R"}, {"family": "Mysiak", "given": "Jaroslav", "initials": "J"}, {"family": "Sillmann", "given": "Jana", "initials": "J"}, {"family": "Stuparu", "given": "Dana", "initials": "D"}, {"family": "West", "given": "Chris", "initials": "C"}], "type": "journal article", "published": "2022-01-11", "journal": {"title": "Clim Risk Manag", "issn": "2212-0963", "pages": "100395", "issn-l": null}, "abstract": "COVID-19 has revealed how challenging it is to manage global, systemic and compounding crises. Like COVID-19, climate change impacts, and maladaptive responses to them, have potential to disrupt societies at multiple scales via networks of trade, finance, mobility and communication, and to impact hardest on the most vulnerable. However, these complex systems can also facilitate resilience if managed effectively. This review aims to distil lessons related to the transboundary management of systemic risks from the COVID-19 experience, to inform climate change policy and resilience building. Evidence from diverse fields is synthesised to illustrate the nature of systemic risks and our evolving understanding of resilience. We describe research methods that aim to capture systemic complexity to inform better management practices and increase resilience to crises. Finally, we recommend specific, practical actions for improving transboundary climate risk management and resilience building. These include mapping the direct, cross-border and cross-sectoral impacts of potential climate extremes, adopting adaptive risk management strategies that embrace heterogenous decision-making and uncertainty, and taking a broader approach to resilience which elevates human wellbeing, including societal and ecological resilience.", "doi": "10.1016/j.crm.2022.100395", "pmid": "35036298", "labels": {"Topics: Register-based research": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2212-0963(22)00002-X"}, {"db": "pmc", "key": "PMC8750828"}], "notes": [], "created": "2022-01-27T07:39:29.268Z", "modified": "2022-01-27T07:39:29.304Z"}, {"entity": "publication", "iuid": "2fb6bea55079411390651ca203fab727", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2fb6bea55079411390651ca203fab727.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2fb6bea55079411390651ca203fab727"}}, "title": "Fighting the COVID pandemic: national policy choices in non-pharmaceutical interventions.", "authors": [{"family": "Alfano", "given": "Vincenzo", "initials": "V"}, {"family": "Ercolano", "given": "Salvatore", "initials": "S"}, {"family": "Pinto", "given": "Mauro", "initials": "M"}], "type": "journal article", "published": "2022-01-11", "journal": {"title": "J Policy Model", "issn": "0161-8938", "issn-l": null}, "abstract": "The COVID-19 pandemic pushed countries to adopt various non-pharmaceutical interventions (NPIs). Due to the features of the pandemic, which spread over time and space, governments could decide whether or not to follow policy choices made by leaders of countries affected by the virus before them. In this study, we aim to empirically model the adoption of NPIs during the first wave of COVID-19 in the 14 European countries with more than 10 million inhabitants, in order to detect whether a policy diffusion mechanism occurred. By means of a multivariate approach based on Principal Component Analysis and Cluster Analysis, we manage to derive three clusters representing different behaviour models to which the different European countries belong in the different periods of the first wave: pre-pandemic, summer relaxation and deep-lockdown scenarios. These results bring a two-fold contribution: on the one hand, they may help us to understand differences and similarities among European countries during the first wave of the COVID-19 outbreak and guide future quantitative or qualitative studies; on the other, our findings suggest that with minor exceptions (such as Sweden and Poland), different countries adopted very similar policy strategies, which are likely to be due more to the unfolding of the pandemic than to specific governmental strategies.", "doi": "10.1016/j.jpolmod.2021.11.003", "pmid": "35034999", "labels": {"Topics: Register-based research": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0161-8938(22)00001-1"}, {"db": "pmc", "key": "PMC8750834"}], "notes": [], "created": "2022-01-27T07:40:32.473Z", "modified": "2022-01-27T07:40:32.509Z"}, {"entity": "publication", "iuid": "8c5a03884ef049498703cc650b5f7eab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c5a03884ef049498703cc650b5f7eab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c5a03884ef049498703cc650b5f7eab"}}, "title": "COVID vaccine-induced pustular psoriasis in patients with previous plaque type psoriasis.", "authors": [{"family": "Piccolo", "given": "Vincenzo", "initials": "V", "orcid": "0000-0001-7798-4368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1ddb3ce197e446dbc8156e8e3222d5e.json"}}, {"family": "Russo", "given": "Teresa", "initials": "T"}, {"family": "Mazzatenta", "given": "Carlo", "initials": "C"}, {"family": "Bassi", "given": "Andrea", "initials": "A", "orcid": "0000-0002-9157-5189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2628d4790c0041b19e8bf037d259ed99.json"}}, {"family": "Argenziano", "given": "Giuseppe", "initials": "G"}, {"family": "Cutrone", "given": "Mario", "initials": "M"}, {"family": "Danielsson Darlington", "given": "Markus", "initials": "M"}, {"family": "Grimalt", "given": "Ramon", "initials": "R"}], "type": "letter", "published": "2022-01-11", "journal": {"title": "J Eur Acad Dermatol Venereol", "issn": "1468-3083", "issn-l": null}, "abstract": null, "doi": "10.1111/jdv.17918", "pmid": "35015916", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-13T21:04:00.367Z", "modified": "2022-01-13T21:04:00.457Z"}, {"entity": "publication", "iuid": "e291a0aa78b34963944fabe6c12277b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e291a0aa78b34963944fabe6c12277b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e291a0aa78b34963944fabe6c12277b1"}}, "title": "A Global Map of COVID-19 Vaccine Acceptance Rates per Country: An Updated Concise Narrative Review.", "authors": [{"family": "Sallam", "given": "Malik", "initials": "M", "orcid": "0000-0002-0165-9670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb490d3ed32f4b76b8a39bd0320bd748.json"}}, {"family": "Al-Sanafi", "given": "Mariam", "initials": "M", "orcid": "0000-0002-1366-3693", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dd8ddbcd9bc49c486fecaa5be0bc2bf.json"}}, {"family": "Sallam", "given": "Mohammed", "initials": "M", "orcid": "0000-0003-3273-524X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d118dbd1d1b4619b46af0480b8670f2.json"}}], "type": "journal article", "published": "2022-01-11", "journal": {"title": "J Multidiscip Healthc", "issn": "1178-2390", "volume": "15", "pages": "21-45", "issn-l": null}, "abstract": "The delay or refusal of vaccination, which defines vaccine hesitancy, is a major challenge to successful control of COVID-19 epidemic. The huge number of publications addressing COVID-19 vaccine hesitancy necessitates periodic review to provide a concise summary of COVID-19 vaccine acceptance rates worldwide. In the current narrative review, data on COVID-19 vaccine acceptance rates were retrieved from surveys in 114 countries/territories. In East and Southern Africa (n = 9), the highest COVID-19 vaccine acceptance rate was reported in Ethiopia (92%), while the lowest rate was reported in Zimbabwe (50%). In West/Central Africa (n = 13), the highest rate was reported in Niger (93%), while the lowest rate was reported in Cameroon (15%). In Asia and the Pacific (n = 16), the highest rates were reported in Nepal and Vietnam (97%), while the lowest rate was reported in Hong Kong (42%). In Eastern Europe/Central Asia (n = 7), the highest rates were reported in Montenegro (69%) and Kazakhstan (64%), while the lowest rate was reported in Russia (30%). In Latin America and the Caribbean (n = 20), the highest rate was reported in Mexico (88%), while the lowest rate was reported in Haiti (43%). In the Middle East/North Africa (MENA, n = 22), the highest rate was reported in Tunisia (92%), while the lowest rate was reported in Iraq (13%). In Western/Central Europe and North America (n = 27), the highest rates were reported in Canada (91%) and Norway (89%), while the lowest rates were reported in Cyprus and Portugal (35%). COVID-19 vaccine acceptance rates \u226560% were seen in 72/114 countries/territories, compared to 42 countries/territories with rates between 13% and 59%. The phenomenon of COVID-19 vaccine hesitancy appeared more pronounced in the MENA, Europe and Central Asia, and Western/Central Africa. More studies are recommended in Africa, Eastern Europe and Central Asia to address intentions of the general public to get COVID-19 vaccination.", "doi": "10.2147/JMDH.S347669", "pmid": "35046661", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "347669"}, {"db": "pmc", "key": "PMC8760993"}], "notes": [], "created": "2022-01-27T07:03:42.486Z", "modified": "2022-01-27T07:03:42.581Z"}, {"entity": "publication", "iuid": "e03da05d0d4141368fbdd11d9def96c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e03da05d0d4141368fbdd11d9def96c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e03da05d0d4141368fbdd11d9def96c9"}}, "title": "Trials and Treatments for Vascular Brain Health: Risk Factor Modification and Cognitive Outcomes.", "authors": [{"family": "Kivipelto", "given": "Miia", "initials": "M", "orcid": "0000-0003-0992-3875", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4fcc583c88c24eb58c1a17bae81d4668.json"}}, {"family": "Palmer", "given": "Katie", "initials": "K", "orcid": "0000-0001-8783-016X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d6ec60063a647308b02d7fd8f72a1b7.json"}}, {"family": "Hoang", "given": "Tina D", "initials": "TD"}, {"family": "Yaffe", "given": "Kristine", "initials": "K", "orcid": "0000-0003-0919-3825", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/827527252aca469880c3424682107e4d.json"}}], "type": "journal article", "published": "2022-01-10", "journal": {"title": "Stroke", "issn": "1524-4628", "pages": "STROKEAHA121032614", "issn-l": null}, "abstract": "There is robust evidence linking vascular health to brain health, cognition, and dementia. In this article, we present evidence from trials of vascular risk factor treatment on cognitive outcomes. We summarize findings from randomized controlled trials of antihypertensives, lipid-lowering medications, diabetes treatments (including antidiabetic drugs versus placebo, and intensive versus standard glycemic control), and multidomain interventions (that target several domains simultaneously such as control of vascular and metabolic factors, nutrition, physical activity, and cognitive stimulation etc). We report that evidence on the efficacy of vascular risk reduction interventions is promising, but not yet conclusive, and several methodological limitations hamper interpretation. Evidence mainly comes from high-income countries and, as cognition and dementia have not been the primary outcomes of many trials, evaluation of cognitive changes have often been limited. As the cognitive aging process occurs over decades, it is unclear whether treatment during the late-life window is optimal for dementia prevention, yet older individuals have been the target of most trials thus far. Further, many trials have not been powered to explore interactions with modifiers such as age, race, and apolipoprotein E, even though sub-analyses from some trials indicate that the success of interventions differs depending on patient characteristics. Due to the complex multifactorial etiology of dementia, and variations in risk factors between individuals, multidomain interventions targeting several risk factors and mechanisms are likely to be needed and the long-term sustainability of preventive interventions will require personalized approaches that could be facilitated by digital health tools. This is especially relevant during the coronavirus disease 2019 (COVID-19) pandemic, where intervention strategies will need to be adapted to the new normal, when face-to-face engagement with participants is limited and public health measures may create changes in lifestyle that affect individuals' vascular risk profiles and subsequent risk of cognitive decline.", "doi": "10.1161/STROKEAHA.121.032614", "pmid": "35000424", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-13T21:12:39.205Z", "modified": "2022-01-13T21:12:53.206Z"}, {"entity": "publication", "iuid": "b05d09cb683c41b095a9898e26e93670", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b05d09cb683c41b095a9898e26e93670.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b05d09cb683c41b095a9898e26e93670"}}, "title": "Repurposing of Medicines in the EU: Launch of a Pilot Framework.", "authors": [{"family": "Asker-Hagelberg", "given": "Charlotte", "initials": "C"}, {"family": "Boran", "given": "Tomas", "initials": "T"}, {"family": "Bouygues", "given": "Christelle", "initials": "C"}, {"family": "Eskola", "given": "Sini Marika", "initials": "SM"}, {"family": "Helmle", "given": "Laszlo", "initials": "L"}, {"family": "Hern\u00e1ndez", "given": "C\u00e9sar", "initials": "C"}, {"family": "Hou\u00fdez", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Lee", "given": "Helen", "initials": "H"}, {"family": "Lingri", "given": "Dimitra D", "initials": "DD"}, {"family": "Louette", "given": "Laurent", "initials": "L"}, {"family": "Meheus", "given": "Lydie", "initials": "L"}, {"family": "Penninckx", "given": "Wim", "initials": "W"}, {"family": "Stepniewska", "given": "Beata", "initials": "B"}], "type": "journal article", "published": "2022-01-10", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "8", "pages": "817663", "issn-l": null}, "abstract": "Repurposing of authorised medicines has been under discussion for a long time. Drug repurposing is the process of identifying a new use for an existing medicine in an indication outside the scope of the original approved indication. Indeed, the COVID-19 health crisis has brought the concept to the frontline by proving the usefulness of this practise in favour of patients for an early access to treatment. Under the umbrella of the Pharmaceutical Committee and as a result of the discussions at the European Commission Expert Group on Safe and Timely Access to Medicines for Patients (STAMP) a virtual Repurposing Observatory Group (RepOG) was set up in 2019 to define and test the practical aspects of a pilot project thought to provide support to \"not-for-profit\" stakeholders generating or gathering data for a new therapeutic use for an authorised medicine. The group's initial plan was impacted by the outbreak of the SARS-CoV-2 pandemic and the launch of the pilot needed to be postponed. This article describes the progress and the activities conducted by the group during this past and yet extraordinary 2020-2021 to keep the project alive and explores on the background of this topic together with the obvious opportunities this health crisis has brought up in terms of repurposing of medicines.", "doi": "10.3389/fmed.2021.817663", "pmid": "35083258", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8784735"}], "notes": [], "created": "2022-01-31T11:48:41.243Z", "modified": "2022-01-31T11:48:41.256Z"}, {"entity": "publication", "iuid": "47d3fbe67a97499d8273b9ea33b939d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47d3fbe67a97499d8273b9ea33b939d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47d3fbe67a97499d8273b9ea33b939d7"}}, "title": "Heroes, victims, and villains in news media narratives about COVID-19. Analysing moralising discourse in Swedish newspaper reporting during the spring of 2020.", "authors": [{"family": "Skog", "given": "Frida", "initials": "F"}, {"family": "Lundstr\u00f6m", "given": "Ragnar", "initials": "R"}], "type": "journal article", "published": "2022-01-10", "journal": {"title": "Soc Sci Med", "issn": "1873-5347", "issn-l": null, "volume": "294", "issue": null, "pages": "114718"}, "abstract": "This paper explores news media discourse about COVID-19 during the spring of 2020 in Sweden, aiming to provide an understanding of how moralising discourse is employed in narratives about public health risks and responses. We investigate print news media content about the corona virus and COVID-19 during the early stages of the outbreak, guided analytically by framework focusing on the relationship between moral panics and moral regulation. We direct attention, first, to how both moral majorities and villains, i.e., 'folk devils', and heroes are constructed in the news. Secondly, we look at how visions for interventions are produced discursively in relation to such constructions. Our findings suggest that moralising discourse largely target risk behaviours and health care claims of middle-class groups. We also find that news media discourse about the pandemic in Sweden is marked by attacks on government interventions that are distinctly different from observations in other contexts. In conclusion, we discuss these observations in relation the political and discursive context, and the potential impact of moralising discourse on the legitimacy of public health interventions and the welfare state. Finally, we also discuss how our findings can inform theoretical discussions about political populism, moralising discourse and public health.", "doi": "10.1016/j.socscimed.2022.114718", "pmid": "35085897", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0277-9536(22)00021-1"}, {"db": "pmc", "key": "PMC8743484"}], "notes": [], "created": "2022-01-31T11:43:59.900Z", "modified": "2022-11-22T05:41:23.500Z"}, {"entity": "publication", "iuid": "2c389a8a7c8646bba44c12940f051816", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c389a8a7c8646bba44c12940f051816.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c389a8a7c8646bba44c12940f051816"}}, "title": "Effective Learning in Virtual Conferences: The Application of Five Principles of Learning.", "authors": [{"family": "Hofst\u00e4dter-Thalmann", "given": "Eva", "initials": "E"}, {"family": "Rotgans", "given": "Jerome I", "initials": "JI", "orcid": "0000-0003-4043-8261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28e7b128b0af4b228210644314f3cca2.json"}}, {"family": "Aybar Perez", "given": "Noelia", "initials": "N"}, {"family": "Nordquist", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2022-01-10", "journal": {"title": "J Eur CME", "issn": "2161-4083", "issn-l": null, "volume": "11", "issue": "1", "pages": "2019435"}, "abstract": "In this article, we examine the adaptation of learning among scientists and healthcare professionals in conferences and symposia from face-to-face to fully virtual meetings accelerated in the last years. Advantages and limitations for both settings have been described in different research studies but the effectiveness of learning can be reflected similarly by applying five fundamental principles of learning, which are based on empirical research in cognitive psychology. From a practical context, we compared the individual learning outcomes from two satellite symposia conducted face-to-face in 2019 and virtually in 2021 at the European Congress of Urology, EAU. Although both conference formats were almost identical, the five principles of learning were applied in both symposia. There were also some differences due to adaptation to online conferences, and our findings suggest that the virtual conference was perceived as significantly more effective than the face-to-face conference on all five criteria, and digital learning is a valid alternative to face-to-face conferences. What still needs to be better understood and analysed is the informal learning that is taking place during conferences, but suggesting an active design of any digital event by combining \"technical literacy\u00b7 with \"learning literacy\" will enable us to better analyse and study the impact of learning using the five learning principles in the design of other events in the future.", "doi": "10.1080/21614083.2021.2019435", "pmid": "35036048", "labels": {"Topics: Register-based research": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "2019435"}, {"db": "pmc", "key": "PMC8757606"}], "notes": [], "created": "2022-01-27T07:39:42.217Z", "modified": "2022-11-22T05:42:08.960Z"}, {"entity": "publication", "iuid": "4e9e8ed8fd3045c4b466ade89269d35e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4e9e8ed8fd3045c4b466ade89269d35e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4e9e8ed8fd3045c4b466ade89269d35e"}}, "title": "Characteristics and outcomes of COVID-19 patients with and without asthma from the United States, South Korea, and Europe.", "authors": [{"family": "Morales", "given": "Daniel", "initials": "D"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Lai", "given": "Lana", "initials": "L"}, {"family": "Sena", "given": "Anthony", "initials": "A"}, {"family": "Duvall", "given": "Scott", "initials": "S"}, {"family": "Suchard", "given": "Marc", "initials": "M"}, {"family": "Verhamme", "given": "Katia", "initials": "K", "orcid": "0000-0001-8162-4904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46ea3f9b89684f919ded6cda30a7170f.json"}}, {"family": "Rjinbeek", "given": "Peter", "initials": "P"}, {"family": "Posada", "given": "Joe", "initials": "J"}, {"family": "Ahmed", "given": "Waheed", "initials": "W"}, {"family": "Alshammary", "given": "Thamer", "initials": "T"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Blacketer", "given": "Clair", "initials": "C"}, {"family": "Burn", "given": "Ed", "initials": "E"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "You", "given": "Seng", "initials": "S"}, {"family": "Dawoud", "given": "Dalia", "initials": "D"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Gong", "given": "Menchung", "initials": "M"}, {"family": "Jonnagaddala", "given": "Jitendra", "initials": "J"}, {"family": "Lynch", "given": "Kristine", "initials": "K"}, {"family": "Matheny", "given": "Michael", "initials": "M"}, {"family": "Minty", "given": "Evan", "initials": "E"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Uribe", "given": "Albert", "initials": "A"}, {"family": "Recalde", "given": "Martina", "initials": "M"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Scheumie", "given": "Martijn", "initials": "M"}, {"family": "Shah", "given": "Karishma", "initials": "K"}, {"family": "Shah", "given": "Nigam", "initials": "N"}, {"family": "Schilling", "given": "Lisa", "initials": "L"}, {"family": "Vizcaya", "given": "David", "initials": "D"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Durate-Salles", "given": "Talita", "initials": "T"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}], "type": "journal article", "published": "2022-01-10", "journal": {"title": "J Asthma", "issn": "1532-4303", "pages": "1-14", "issn-l": null}, "abstract": "Objective: Large international comparisons describing the clinical characteristics of patients with COVID-19 are limited. The aim of the study was to perform a large-scale descriptive characterization of COVID-19 patients with asthma.Methods: We included nine databases contributing data from January-June 2020 from the US, South Korea (KR), Spain, UK and the Netherlands. We defined two cohorts of COVID-19 patients ('diagnosed' and 'hospitalized') based on COVID-19 disease codes. We followed patients from COVID-19 index date to 30 days or death. We performed descriptive analysis and reported the frequency of characteristics and outcomes in people with asthma defined by codes and prescriptions.Results: The diagnosed and hospitalized cohorts contained 666,933 and 159,552 COVID-19 patients respectively. Exacerbation in people with asthma was recorded in 1.6%-8.6% of patients at presentation. Asthma prevalence ranged from 6.2% (95%CI 5.7-6.8) to 18.5% (95%CI 18.2-18.8) in the diagnosed cohort and 5.2% (95%CI 4.0-6.8) to 20.5% (95%CI 18.6-22.6) in the hospitalized cohort. Asthma patients with COVID-19 had high prevalence of comorbidity including hypertension, heart disease, diabetes and obesity. Mortality ranged from 2.1% (95%CI 1.8-2.4) to 16.9% (95%CI 13.8-20.5) and similar or lower compared to COVID-19 patients without asthma. Acute respiratory distress syndrome occurred in 15%-30% of hospitalized COVID-19 asthma patients.Conclusion: The prevalence of asthma among COVID-19 patients varies internationally. Asthma patients with COVID-19 have high comorbidity. The prevalence of asthma exacerbation at presentation was low. Whilst mortality was similar among COVID-19 patients with and without asthma, this could be confounded by differences in clinical characteristics. Further research could help identify high-risk asthma patients.", "doi": "10.1080/02770903.2021.2025392", "pmid": "35012410", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-13T21:06:24.354Z", "modified": "2022-01-13T21:06:34.436Z"}, {"entity": "publication", "iuid": "1d45408f77254505981cbcae69859833", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d45408f77254505981cbcae69859833.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d45408f77254505981cbcae69859833"}}, "title": "COVID-19 pandemic impact on cytopathology practice in the post-lockdown period: An international, multicenter study.", "authors": [{"family": "Vigliar", "given": "Elena", "initials": "E"}, {"family": "Pisapia", "given": "Pasquale", "initials": "P", "orcid": "0000-0002-6429-0620", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/852012229c1845389cd2edf7be3bc629.json"}}, {"family": "Dello Iacovo", "given": "Filippo", "initials": "F"}, {"family": "Alcaraz-Mateos", "given": "Eduardo", "initials": "E"}, {"family": "Al\u00ec", "given": "Greta", "initials": "G"}, {"family": "Ali", "given": "Syed Z", "initials": "SZ"}, {"family": "Baloch", "given": "Zubair W", "initials": "ZW"}, {"family": "Bellevicine", "given": "Claudio", "initials": "C", "orcid": "0000-0002-7479-6457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d949e1ed72c2460a8063ee8be1bc5943.json"}}, {"family": "Bongiovanni", "given": "Massimo", "initials": "M", "orcid": "0000-0001-9846-6682", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84e33246c3844d6cb5682085e59a8401.json"}}, {"family": "Botsun", "given": "Pavlina", "initials": "P"}, {"family": "Bruzzese", "given": "Dario", "initials": "D"}, {"family": "Bubendorf", "given": "Lukas", "initials": "L", "orcid": "0000-0001-5970-1803", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00e786919dfd4d7a9ad0c5fcb93e1f10.json"}}, {"family": "B\u00fcttner", "given": "Reinhard", "initials": "R"}, {"family": "Canberk", "given": "Sule", "initials": "S", "orcid": "0000-0002-3736-1323", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26dc73d74c604ce3bab1ca1f7c55561b.json"}}, {"family": "Capitanio", "given": "Arrigo", "initials": "A"}, {"family": "Casadio", "given": "Chiara", "initials": "C"}, {"family": "Cazacu", "given": "Eugeniu", "initials": "E"}, {"family": "Cochand-Priollet", "given": "Beatrix", "initials": "B"}, {"family": "D'Amuri", "given": "Alessandro", "initials": "A"}, {"family": "Davis", "given": "Katelynn", "initials": "K"}, {"family": "Eloy", "given": "Catarina", "initials": "C", "orcid": "0000-0001-7642-1280", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf436dea894e4c7fa1c499b83d218f39.json"}}, {"family": "Engels", "given": "Marianne", "initials": "M"}, {"family": "Fadda", "given": "Guido", "initials": "G"}, {"family": "Fontanini", "given": "Gabriella", "initials": "G"}, {"family": "Fulciniti", "given": "Franco", "initials": "F"}, {"family": "Hofman", "given": "Paul", "initials": "P", "orcid": "0000-0003-0431-9353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80753da68c474a46a5fd85c76e468fdb.json"}}, {"family": "Iaccarino", "given": "Antonino", "initials": "A"}, {"family": "Ieni", "given": "Antonio", "initials": "A"}, {"family": "Jiang", "given": "Xiaoyin Sara", "initials": "XS", "orcid": "0000-0002-3069-3130", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5826f5fd5af4a84ac308e9368fbcad9.json"}}, {"family": "Kakudo", "given": "Kennichi", "initials": "K", "orcid": "0000-0002-0347-7264", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2cbc47cb73124e98ac7d540b562f0b97.json"}}, {"family": "Kern", "given": "Izidor", "initials": "I"}, {"family": "Kholova", "given": "Ivana", "initials": "I"}, {"family": "Linton McDermott", "given": "Kathryn M", "initials": "KM"}, {"family": "Liu", "given": "Chinhua", "initials": "C"}, {"family": "Lobo", "given": "Anandi", "initials": "A"}, {"family": "Lozano", "given": "Maria D", "initials": "MD", "orcid": "0000-0002-6796-9380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54800a1ac917410c9cfa7ab5f3b22bc2.json"}}, {"family": "Malapelle", "given": "Umberto", "initials": "U"}, {"family": "Maleki", "given": "Zahra", "initials": "Z", "orcid": "0000-0003-3273-4802", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31b3a0890ae1476abfa8eb1bfd8df3ee.json"}}, {"family": "Michelow", "given": "Pamela", "initials": "P"}, {"family": "Mikula", "given": "Michael W", "initials": "MW"}, {"family": "Musayev", "given": "Jamal", "initials": "J"}, {"family": "\u00d6zg\u00fcn", "given": "Gonca", "initials": "G"}, {"family": "Oznur", "given": "Meltem", "initials": "M"}, {"family": "Peir\u00f3 Marqu\u00e9s", "given": "Francisca Maria", "initials": "FM"}, {"family": "Poller", "given": "David", "initials": "D"}, {"family": "Pyzlak", "given": "Michal", "initials": "M"}, {"family": "Robinson", "given": "Betsy", "initials": "B"}, {"family": "Rossi", "given": "Esther Diana", "initials": "ED", "orcid": "0000-0003-3819-4229", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/353c4e390a6646f0a52cd11d0ec6aeb7.json"}}, {"family": "Roy-Chowdhuri", "given": "Sinchita", "initials": "S", "orcid": "0000-0002-9447-7701", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ca8b8486db4f45eebd213b3d4770fa0f.json"}}, {"family": "Saieg", "given": "Mauro", "initials": "M", "orcid": "0000-0002-9438-226X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/921ab9772dbb44e69e06da15d306ca48.json"}}, {"family": "Savic Prince", "given": "Spasenija", "initials": "S"}, {"family": "Schmitt", "given": "Fernando C", "initials": "FC"}, {"family": "Segu\u00ed Iv\u00e1\u00f1ez", "given": "Francisco Javier", "initials": "FJ"}, {"family": "\u0160toos-Vei\u0107", "given": "Tajana", "initials": "T"}, {"family": "Sulaieva", "given": "Oksana", "initials": "O"}, {"family": "Sweeney", "given": "Brenda J", "initials": "BJ"}, {"family": "Tuccari", "given": "Giovanni", "initials": "G"}, {"family": "van Velthuysen", "given": "Marie-Louise", "initials": "ML"}, {"family": "VanderLaan", "given": "Paul A", "initials": "PA", "orcid": "0000-0002-7234-5652", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d17424496a6b41efbc5d6fba770344a8.json"}}, {"family": "Vielh", "given": "Philippe", "initials": "P"}, {"family": "Viola", "given": "Patrizia", "initials": "P"}, {"family": "Voorham", "given": "Quirinus J M", "initials": "QJM"}, {"family": "Weynand", "given": "Birgit", "initials": "B"}, {"family": "Zeppa", "given": "Pio", "initials": "P", "orcid": "0000-0001-7358-5925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9687953aaff245c8aa33b11d17655cbf.json"}}, {"family": "Faquin", "given": "William C", "initials": "WC", "orcid": "0000-0002-9043-7171", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf42ad6f77864413a0a1d273f6a6c977.json"}}, {"family": "Pitman", "given": "Martha Bishop", "initials": "MB"}, {"family": "Troncone", "given": "Giancarlo", "initials": "G", "orcid": "0000-0003-1630-5805", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a12ba1f7a12141b6b95e6e715b12e9db.json"}}], "type": "journal article", "published": "2022-01-10", "journal": {"title": "Cancer Cytopathol", "issn": "1934-6638", "issn-l": null}, "abstract": "In a previous worldwide survey, the authors showed a drastic reduction in the number of cytological specimens processed during the coronavirus disease 2019 \"lockdown\" period along with an increase in malignancy rates. To assess the continued impact of the pandemic on cytological practices around the world, they undertook a second follow-up worldwide survey collecting data from the post-lockdown period (2020).\n\nParticipants were asked to provide data regarding their cytopathology activity during the first 12 weeks of their respective national post-lockdown period (2020), which ranged from April 4 to October 31. Differences between the post-lockdown period and the corresponding 2019 period were evaluated, and the authors specifically focused on rates of malignant diagnoses.\n\nA total of 29 respondents from 17 countries worldwide joined the survey. Overall, a lower number of cytological specimens (n = 236,352) were processed in comparison with the same period in 2019 (n = 321,466) for a relative reduction of 26.5%. The overall malignancy rate showed a statistically significant increase (12,442 [5.26%] vs 12,882 [4.01%]; P < .001) during the same time period. Similar results were obtained if both malignancy and suspicious for malignancy rates were considered together (15,759 [6.58%] vs 16,011 [4.98%]; P < .001).\n\nThe data showed a persistent reduction in the cytological specimen volume during the post-lockdown period (2020). However, the relative increase in the cytological workload in the late part of the post-lockdown is a promising finding of a slow return to normality.", "doi": "10.1002/cncy.22547", "pmid": "35006650", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-13T21:09:27.944Z", "modified": "2022-01-13T21:09:28.530Z"}, {"entity": "publication", "iuid": "0e7c6e43fa9549238ec093d52cb77749", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e7c6e43fa9549238ec093d52cb77749.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e7c6e43fa9549238ec093d52cb77749"}}, "title": "A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo.", "authors": [{"family": "Hanke", "given": "Leo", "initials": "L", "orcid": "0000-0001-5514-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a35f10de4f2e4aee98278f6ab845613d.json"}}, {"family": "Das", "given": "Hrishikesh", "initials": "H", "orcid": "0000-0001-7495-7065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/496d4befba454f3f85e23ddd413ada9c.json"}}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Perez Vidakovics", "given": "Laura", "initials": "L", "orcid": "0000-0003-4283-812X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b85cf54481e94b8c95f2bf8db1038395.json"}}, {"family": "Urgard", "given": "Egon", "initials": "E"}, {"family": "Moliner-Morro", "given": "Ainhoa", "initials": "A"}, {"family": "Kim", "given": "Changil", "initials": "C", "orcid": "0000-0003-4977-4384", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d36347170c34ca386deee72faccc534.json"}}, {"family": "Karl", "given": "Vivien", "initials": "V"}, {"family": "Pankow", "given": "Alec", "initials": "A"}, {"family": "Smith", "given": "Natalie L", "initials": "NL"}, {"family": "Porebski", "given": "Bartlomiej", "initials": "B"}, {"family": "Fernandez-Capetillo", "given": "Oscar", "initials": "O"}, {"family": "Sezgin", "given": "Erdinc", "initials": "E", "orcid": "0000-0002-4915-388X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30c3688527ac4caf8d07426703ace615.json"}}, {"family": "Pedersen", "given": "Gabriel K", "initials": "GK"}, {"family": "Coquet", "given": "Jonathan M", "initials": "JM", "orcid": "0000-0002-5967-4857", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ca3e4664dc444a3a992531ad3dd9201.json"}}, {"family": "H\u00e4llberg", "given": "B Martin", "initials": "BM", "orcid": "0000-0002-6781-0345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea241fd233ca40a6be4ffa1472d2aa06.json"}}, {"family": "Murrell", "given": "Ben", "initials": "B", "orcid": "0000-0002-0393-4445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60dac9ecf84d4eb3b90fb4ee1298bc52.json"}}, {"family": "McInerney", "given": "Gerald M", "initials": "GM", "orcid": "0000-0003-2257-7241", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7770437d845444a8a07865bf5b62fab0.json"}}], "type": "journal article", "published": "2022-01-10", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "13", "issue": "1", "pages": "155"}, "abstract": "Antibodies binding to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike have therapeutic promise, but emerging variants show the potential for virus escape. This emphasizes the need for therapeutic molecules with distinct and novel neutralization mechanisms. Here we describe the isolation of a nanobody that interacts simultaneously with two RBDs from different spike trimers of SARS-CoV-2, rapidly inducing the formation of spike trimer-dimers leading to the loss of their ability to attach to the host cell receptor, ACE2. We show that this nanobody potently neutralizes SARS-CoV-2, including the beta and delta variants, and cross-neutralizes SARS-CoV. Furthermore, we demonstrate the therapeutic potential of the nanobody against SARS-CoV-2 and the beta variant in a human ACE2 transgenic mouse model. This naturally elicited bispecific monomeric nanobody establishes an uncommon strategy for potent inactivation of viral antigens and represents a promising antiviral against emerging SARS-CoV-2 variants.", "doi": "10.1038/s41467-021-27610-z", "pmid": "35013189", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Funder: H2020": null, "Research Area: Drug discovery and repurposing of drugs": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC8748511"}, {"db": "URL", "key": "https://www.ebi.ac.uk/emdb/EMD-12465", "description": "https://www.ebi.ac.uk/emdb/EMD-12465"}, {"db": "URL", "key": "https://www.ebi.ac.uk/emdb/EMD-12461", "description": "https://www.ebi.ac.uk/emdb/EMD-12461"}], "notes": [], "created": "2022-01-11T06:56:36.794Z", "modified": "2022-02-17T08:51:26.108Z"}, {"entity": "publication", "iuid": "4f962a14f58b4d73ae2463bc11156c41", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4f962a14f58b4d73ae2463bc11156c41.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4f962a14f58b4d73ae2463bc11156c41"}}, "title": "Premature mortality attributable to COVID-19: potential years of life lost in 17 countries around the world, January-August 2020.", "authors": [{"family": "Ugarte", "given": "Maider Pagola", "initials": "MP"}, {"family": "Achilleos", "given": "Souzana", "initials": "S", "orcid": "0000-0002-1688-9225", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce5b51f054484805abea56ebad2bffc6.json"}}, {"family": "Quattrocchi", "given": "Annalisa", "initials": "A"}, {"family": "Gabel", "given": "John", "initials": "J"}, {"family": "Kolokotroni", "given": "Ourania", "initials": "O"}, {"family": "Constantinou", "given": "Constantina", "initials": "C"}, {"family": "Nicolaou", "given": "Nicoletta", "initials": "N"}, {"family": "Rodriguez-Llanes", "given": "Jose Manuel", "initials": "JM"}, {"family": "Huang", "given": "Qian", "initials": "Q"}, {"family": "Verstiuk", "given": "Olesia", "initials": "O"}, {"family": "Pidmurniak", "given": "Nataliia", "initials": "N"}, {"family": "Tao", "given": "Jennifer Wenjing", "initials": "JW"}, {"family": "Burstr\u00f6m", "given": "Bo", "initials": "B"}, {"family": "Klepac", "given": "Petra", "initials": "P"}, {"family": "Erzen", "given": "Ivan", "initials": "I"}, {"family": "Chong", "given": "Mario", "initials": "M"}, {"family": "Barron", "given": "Manuel", "initials": "M"}, {"family": "Hagen", "given": "Terje P", "initials": "TP"}, {"family": "Kalmatayeva", "given": "Zhanna", "initials": "Z"}, {"family": "Davletov", "given": "Kairat", "initials": "K"}, {"family": "Zucker", "given": "Inbar", "initials": "I"}, {"family": "Kaufman", "given": "Zalman", "initials": "Z"}, {"family": "Kereselidze", "given": "Maia", "initials": "M"}, {"family": "Kandelaki", "given": "Levan", "initials": "L"}, {"family": "Le Meur", "given": "Nolwenn", "initials": "N"}, {"family": "Goldsmith", "given": "Lucy", "initials": "L"}, {"family": "Critchley", "given": "Julia A", "initials": "JA"}, {"family": "Pinilla", "given": "Maria Angelica", "initials": "MA"}, {"family": "Jaramillo", "given": "Gloria Isabel", "initials": "GI"}, {"family": "Teixeira", "given": "Domingos", "initials": "D"}, {"family": "Gom\u00e9z", "given": "Lara Ferrero", "initials": "LF"}, {"family": "Lobato", "given": "Jackeline", "initials": "J"}, {"family": "Ara\u00fajo", "given": "Carolina", "initials": "C"}, {"family": "Cuthbertson", "given": "Joseph", "initials": "J"}, {"family": "Bennett", "given": "Catherine M", "initials": "CM"}, {"family": "Polemitis", "given": "Antonis", "initials": "A"}, {"family": "Charalambous", "given": "Andreas", "initials": "A"}, {"family": "Demetriou", "given": "Christiana A", "initials": "CA"}, {"family": "C-MOR consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2022-01-09", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "54", "issn-l": null}, "abstract": "Understanding the impact of the burden of COVID-19 is key to successfully navigating the COVID-19 pandemic. As part of a larger investigation on COVID-19 mortality impact, this study aims to estimate the Potential Years of Life Lost (PYLL) in 17 countries and territories across the world (Australia, Brazil, Cape Verde, Colombia, Cyprus, France, Georgia, Israel, Kazakhstan, Peru, Norway, England & Wales, Scotland, Slovenia, Sweden, Ukraine, and the United States [USA]).\n\nAge- and sex-specific COVID-19 death numbers from primary national sources were collected by an international research consortium. The study period was established based on the availability of data from the inception of the pandemic to the end of August 2020. The PYLL for each country were computed using 80 years as the maximum life expectancy.\n\nAs of August 2020, 442,677 (range: 18-185,083) deaths attributed to COVID-19 were recorded in 17 countries which translated to 4,210,654 (range: 112-1,554,225) PYLL. The average PYLL per death was 8.7 years, with substantial variation ranging from 2.7 years in Australia to 19.3 PYLL in Ukraine. North and South American countries as well as England & Wales, Scotland and Sweden experienced the highest PYLL per 100,000 population; whereas Australia, Slovenia and Georgia experienced the lowest. Overall, males experienced higher PYLL rate and higher PYLL per death than females. In most countries, most of the PYLL were observed for people aged over 60 or 65 years, irrespective of sex. Yet, Brazil, Cape Verde, Colombia, Israel, Peru, Scotland, Ukraine, and the USA concentrated most PYLL in younger age groups.\n\nOur results highlight the role of PYLL as a tool to understand the impact of COVID-19 on demographic groups within and across countries, guiding preventive measures to protect these groups under the ongoing pandemic. Continuous monitoring of PYLL is therefore needed to better understand the burden of COVID-19 in terms of premature mortality.", "doi": "10.1186/s12889-021-12377-1", "pmid": "35000578", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-12377-1"}], "notes": [], "created": "2022-01-13T21:12:19.822Z", "modified": "2022-01-13T21:12:19.852Z"}, {"entity": "publication", "iuid": "5a5acc90669347b880b44b80f950c5b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5a5acc90669347b880b44b80f950c5b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5a5acc90669347b880b44b80f950c5b3"}}, "title": "Occupation and COVID-19 diagnosis, hospitalisation and ICU admission among foreign-born and Swedish-born employees: a register-based study.", "authors": [{"family": "Nwaru", "given": "Chioma Adanma", "initials": "CA", "orcid": "0000-0002-1772-2347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/901880ae4f9143cc96fedf11aa673bc7.json"}}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Franz\u00e9n", "given": "Stefan", "initials": "S"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}], "type": "journal article", "published": "2022-01-07", "journal": {"title": "J Epidemiol Community Health", "issn": "1470-2738", "issn-l": null}, "abstract": "Research on occupation and risk of COVID-19 among foreign-born workers is lacking. We investigated whether working in essential occupations was associated with COVID-19 diagnosis, hospitalisation and intensive care unit (ICU) admission and whether foreign-born workers in similar occupations as Swedish-born individuals had a higher risk of the studied outcomes.\n\nOccupational data (2018-2019) of 326 052 employees (20-65 years) who were resident in Sweden as of 1 January 2020 were linked to COVID-19 data registered from 1 January 2020 to 28 February 2021. We analysed the risk of COVID-19 outcomes in different occupational groups and in four immigrant/occupation intersectional groups using Cox proportional hazards regression with adjustments for sociodemographic and socioeconomic characteristics and pre-existing comorbidities.\n\nWe identified 29797, 1069 and 152 cases of COVID-19 diagnosis, hospitalisations and ICU admissions, respectively, in our cohort. Workers in essential occupations had an elevated risk of COVID-19 diagnosis, hospitalisation, and ICU admissions. Healthcare workers had a higher risk of all the outcomes compared with other essential workers. Relative to Swedish-born workers in non-essential occupations, foreign-born workers in essential occupations had 1.85 (95% CI 1.78 to 1.93), 3.80 (95% CI 3.17 to 4.55) and 3.79 (95% CI 2.33 to 6.14) times higher risk of COVID-19 diagnosis, hospitalisation and ICU admission, respectively. The corresponding risks among Swedish-born workers in essential occupations were 1.44 (95% CI 1.40 to 1.49), 1.30 (95% CI 1.08 to 1.56) and 1.46 (95% CI 0.90 to 2.38).\n\nOccupation was associated with COVID-19 outcomes and contributed to the burden of COVID-19 among foreign-born individuals in this study.", "doi": "10.1136/jech-2021-218278", "pmid": "34996808", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "jech-2021-218278"}], "notes": [], "created": "2022-01-10T15:29:08.356Z", "modified": "2022-01-10T15:29:08.430Z"}, {"entity": "publication", "iuid": "52e1e554737e44d5996fffab9096eb18", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/52e1e554737e44d5996fffab9096eb18.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/52e1e554737e44d5996fffab9096eb18"}}, "title": "Immunity to SARS-CoV-2 up to 15 months after infection.", "authors": [{"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Piralla", "given": "Antonio", "initials": "A"}, {"family": "Zuo", "given": "Fanglei", "initials": "F"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Cassaniti", "given": "Irene", "initials": "I"}, {"family": "Wan", "given": "Hui", "initials": "H"}, {"family": "Kumagai-Braesh", "given": "Makiko", "initials": "M"}, {"family": "Andr\u00e9ll", "given": "Juni", "initials": "J"}, {"family": "Percivalle", "given": "Elena", "initials": "E"}, {"family": "Sammartino", "given": "Jos\u00e8 Camilla", "initials": "JC"}, {"family": "Wang", "given": "Yating", "initials": "Y"}, {"family": "Vlachiotis", "given": "Stelios", "initials": "S"}, {"family": "Attevall", "given": "Janine", "initials": "J"}, {"family": "Bergami", "given": "Federica", "initials": "F"}, {"family": "Ferrari", "given": "Alessandro", "initials": "A"}, {"family": "Colaneri", "given": "Marta", "initials": "M"}, {"family": "Vecchia", "given": "Marco", "initials": "M"}, {"family": "Sambo", "given": "Margherita", "initials": "M"}, {"family": "Zuccaro", "given": "Valentina", "initials": "V"}, {"family": "Asperges", "given": "Erika", "initials": "E"}, {"family": "Bruno", "given": "Raffaele", "initials": "R"}, {"family": "Oggionni", "given": "Tiberio", "initials": "T"}, {"family": "Meloni", "given": "Federica", "initials": "F"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Bertoglio", "given": "Federico", "initials": "F"}, {"family": "Schubert", "given": "Maren", "initials": "M"}, {"family": "Calzolai", "given": "Luigi", "initials": "L"}, {"family": "Varani", "given": "Luca", "initials": "L"}, {"family": "Hust", "given": "Michael", "initials": "M"}, {"family": "Xue", "given": "Yintong", "initials": "Y"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}], "type": "journal article", "published": "2022-01-07", "journal": {"title": "iScience", "issn": "2589-0042", "pages": "103743", "issn-l": "2589-0042"}, "abstract": "Information concerning the longevity of immunity to SARS-CoV-2 following natural infection may have considerable implications for durability of immunity induced by vaccines. Here, we monitored the SARS-CoV-2 specific immune response in COVID-19 patients followed up to 15 months after symptoms onset. Following a peak at day 15-28 post-infection, the IgG antibody response and plasma neutralizing titers gradually decreased over time but stabilized after 6 months. Compared to G614, plasma neutralizing titers were more than 8-fold lower against variants Beta, Gamma and Delta. SARS-CoV-2-specific memory B and T cells persisted in the majority of patients up to 15 months although a significant decrease in specific T cells, but not B cells, was observed between 6 and 15 months. The antiviral specific immunity especially memory B cells in COVID-19 convalescent patients is long-lasting, but some variants of concern may at least partially escape the neutralizing activity of plasma antibodies.", "doi": "10.1016/j.isci.2022.103743", "pmid": "35018336", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(22)00013-X"}, {"db": "pmc", "key": "PMC8736281"}], "notes": [], "created": "2022-01-13T20:59:32.521Z", "modified": "2022-01-13T20:59:32.535Z"}, {"entity": "publication", "iuid": "2fa81706e5ad425182dc27b9e57922ac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2fa81706e5ad425182dc27b9e57922ac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2fa81706e5ad425182dc27b9e57922ac"}}, "title": "COVID-19 related outcomes among individuals with neurodegenerative diseases: a cohort analysis in the UK biobank.", "authors": [{"family": "Hu", "given": "Yihan", "initials": "Y"}, {"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Hou", "given": "Can", "initials": "C"}, {"family": "Chen", "given": "Wenwen", "initials": "W"}, {"family": "Zhang", "given": "Hanyue", "initials": "H"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Sun", "given": "Yajing", "initials": "Y"}, {"family": "Qu", "given": "Yuanyuan", "initials": "Y"}, {"family": "Feychting", "given": "Maria", "initials": "M"}, {"family": "Valdimarsdottir", "given": "Unnur", "initials": "U"}, {"family": "Song", "given": "Huan", "initials": "H", "orcid": "0000-0003-3845-8079", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2e35902226b407487330fc6c7368759.json"}}, {"family": "Fang", "given": "Fang", "initials": "F"}], "type": "journal article", "published": "2022-01-07", "journal": {"title": "BMC Neurol", "issn": "1471-2377", "volume": "22", "issue": "1", "pages": "15", "issn-l": null}, "abstract": "An increased susceptibility to COVID-19 has been suggested for individuals with neurodegenerative diseases, but data are scarce from longitudinal studies.\n\nIn this community-based cohort study, we included 96,275 participants of the UK Biobank who had available SARS-CoV-2 test results in Public Health England. Of these, 2617 had a clinical diagnosis of neurodegenerative diseases in the UK Biobank inpatient hospital data before the outbreak of COVID-19 (defined as January 31st, 2020), while the remaining participants constituted the reference group. We then followed both groups from January 31st, 2020 to June 14th, 2021 for ascertainment of COVID-19 outcomes, including any COVID-19, inpatient care for COVID-19, and COVID-19 related death. Logistic regression was applied to estimate the association between neurogenerative disease and risks of COVID-19 outcomes, adjusted for multiple confounders and somatic comorbidities.\n\nWe observed an elevated risk of COVID-19 outcomes among individuals with a neurodegenerative disease compared with the reference group, corresponding to a fully adjusted odds ratio of 2.47 (95%CI 2.25-2.71) for any COVID-19, 2.18 (95%CI 1.94-2.45) for inpatient COVID-19, and 3.67 (95%CI 3.11-4.34) for COVID-19 related death. Among individuals with a positive test result for SARS-CoV-2, individuals with neurodegenerative diseases had also a higher risk of COVID-19 related death than others (fully adjusted odds ratio 2.08; 95%CI 1.71-2.53).\n\nAmong UK Biobank participants who received at least one test for SARS-CoV-2, a pre-existing diagnosis of neurodegenerative disease was associated with a subsequently increased risk of COVID-19, especially COVID-19 related death.", "doi": "10.1186/s12883-021-02536-7", "pmid": "34996388", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8739517"}, {"db": "pii", "key": "10.1186/s12883-021-02536-7"}], "notes": [], "created": "2022-01-10T15:30:44.904Z", "modified": "2023-06-19T14:48:12.016Z"}, {"entity": "publication", "iuid": "57157113a28045798857617d872a36db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/57157113a28045798857617d872a36db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/57157113a28045798857617d872a36db"}}, "title": "COVID-19 collateral damage-psychological burden and behavioural changes among older adults during the first outbreak in Stockholm, Sweden: a cross-sectional study.", "authors": [{"family": "Beridze", "given": "Giorgi", "initials": "G", "orcid": "0000-0002-2615-226X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0a1b88868e743d180580c5545dc3b3f.json"}}, {"family": "Triolo", "given": "Federico", "initials": "F"}, {"family": "Grande", "given": "Giulia", "initials": "G"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A", "orcid": "0000-0001-9064-9222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/166407b0da5346b3aef841949b0212da.json"}}], "type": "journal article", "published": "2022-01-07", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "1", "pages": "e058422", "issn-l": "2044-6055"}, "abstract": "To explore the indirect negative effects of COVID-19 restrictions (collateral damage) on the lives and health of older adults living in central Stockholm, and to characterise the sociodemographic profile of those with the highest susceptibility to this damage.\n\nCross-sectional study.\n\nDistrict of Kungsholmen in Stockholm, Sweden.\n\nOlder adults aged 68 years and above (n=1231) who participated in the ad hoc COVID-19-related phone questionnaire administered by trained staff between May and June 2020 and who had previously attended the regular follow-up assessment of the Swedish National study on Aging and Care in Kungsholmen (SNAC-K) during 2016-2019.\n\nThree dimensions of collateral damage: psychological burden (feelings of worry, stress and loneliness), reductions in social and physical activities, and reductions in medical and social care use since the beginning of the pandemic. Logistic regression models were used to test the association between age, sex, education and living arrangement, and the risk of collateral damage.\n\nVast majority of participants adhered to the national public health recommendations, with over three-quarters practising self-isolation (n=928). Half of the sample reported psychological burden, 55.3% reported reductions in social or physical activity, and 11.3% reported decreased medical or social care use. Over three quarters of participants (77.8%) were affected by at least one of the three collateral damage dimensions. Female sex was the strongest sociodemographic predictor of both individual and co-occurring dimensions of collateral damage.\n\nCOVID-19 and its restrictions during the first half of 2020 had a negative effect on the health and lives of a majority of the elderly living in central Stockholm. Women were at a higher risk of these negative consequences. We emphasise the need for predefined, evidence-based interventions to support those who are most susceptible to these consequences, both during the pandemic and once the outbreak is overcome.", "doi": "10.1136/bmjopen-2021-058422", "pmid": "34996805", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-058422"}], "notes": [], "created": "2022-01-10T15:29:48.426Z", "modified": "2022-01-10T15:29:48.506Z"}, {"entity": "publication", "iuid": "11d995e1fa8945db86dd93e86bc0fe4a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/11d995e1fa8945db86dd93e86bc0fe4a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/11d995e1fa8945db86dd93e86bc0fe4a"}}, "title": "What Do Physicians Think About the Use of Telemedicine to Recruit and Assess Participants in mHealth-Related Clinical Studies as a Consequence of the COVID-19 Pandemic?", "authors": [{"family": "Pereira", "given": "Ana Margarida", "initials": "AM", "orcid": "0000-0002-5468-0932", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8bb795e913654a9d80a82086f074f65c.json"}}, {"family": "Almeida", "given": "Rute", "initials": "R"}, {"family": "Amaral", "given": "Rita", "initials": "R"}, {"family": "Alves-Correia", "given": "Magna", "initials": "M"}, {"family": "Mendes", "given": "Sandra", "initials": "S"}, {"family": "Fonseca", "given": "Jo\u00e3o Almeida", "initials": "JA"}, {"family": "J\u00e1come", "given": "Cristina", "initials": "C"}], "type": "journal article", "published": "2022-01-06", "journal": {"title": "Telemed J E Health", "issn": "1556-3669", "issn-l": null}, "abstract": "Objectives:To evaluate physician's opinion and availability to participate in mHealth-related clinical studies with patient recruitment and assessment via telemedicine and to identify characteristics associated with the willingness to participate. Methods:Cross-sectional, observational study, based on an anonymous web survey conducted in May-Jun of 2020 to 237 physicians, from Portugal and Spain that collaborated with an asthma mHealth project (INSPIRERS). Results:Response rate was 51% (n = 120). Most (74%, n = 89) physicians were available to participate in such studies, but 62% anticipated lower recruiting capacity and 40% increased difficulty in obtaining quality data. Physicians aged \u226440 years, from secondary care (vs. general practitioners) and that used apps in personal life or clinical practice were more likely to be available. Conclusions:Three-quarters of the physicians were available to participate in mHealth-related clinical studies with patient recruitment and assessment through telemedicine. Age group, medical specialty, and app use were associated with the willingness to participate.", "doi": "10.1089/tmj.2021.0462", "pmid": "34990295", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-01-10T15:33:44.220Z", "modified": "2022-01-10T15:33:44.300Z"}, {"entity": "publication", "iuid": "901e928acfc04a9bab8320ab02f54b3e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/901e928acfc04a9bab8320ab02f54b3e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/901e928acfc04a9bab8320ab02f54b3e"}}, "title": "The Views and Needs of People With Parkinson Disease Regarding Wearable Devices for Disease Monitoring: Mixed Methods Exploration.", "authors": [{"family": "Kenny", "given": "Lorna", "initials": "L", "orcid": "0000-0002-5351-3091", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c99b991bb46f40c48d2bd92e392a431d.json"}}, {"family": "Moore", "given": "Kevin", "initials": "K", "orcid": "0000-0003-0712-2222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26393cb529d64dd4b4c4250b2af2cfce.json"}}, {"family": "O' Riordan", "given": "Cl\u00edona", "initials": "C", "orcid": "0000-0002-0509-3141", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eac991a073e040dcad6217fd9a272cc4.json"}}, {"family": "Fox", "given": "Siobhan", "initials": "S", "orcid": "0000-0002-6854-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a51699627a4f48efa9149b4e3642da49.json"}}, {"family": "Barton", "given": "John", "initials": "J", "orcid": "0000-0002-0671-5678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8c553326196499e8e842ea2cc53932f.json"}}, {"family": "Tedesco", "given": "Salvatore", "initials": "S", "orcid": "0000-0002-7752-2240", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0356fa19135145ad82e2a0738f0391b7.json"}}, {"family": "Sica", "given": "Marco", "initials": "M", "orcid": "0000-0003-4188-4482", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b03fc2e7f34843229b1ca469c08959b5.json"}}, {"family": "Crowe", "given": "Colum", "initials": "C", "orcid": "0000-0002-7479-9922", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb5c7f1c8b754c9b8ecde7025b1e9bc7.json"}}, {"family": "Alam\u00e4ki", "given": "Antti", "initials": "A", "orcid": "0000-0001-6293-6232", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b7b4de949974b03ac1a20387ec77ec8.json"}}, {"family": "Condell", "given": "Joan", "initials": "J", "orcid": "0000-0002-3517-2182", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56fb9f68e28547a6a93e5786726f41d7.json"}}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A", "orcid": "0000-0003-3534-456X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26229455bc3d42f6aea6b541c4d74b48.json"}}, {"family": "Timmons", "given": "Suzanne", "initials": "S", "orcid": "0000-0001-7790-9552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9bb14fd40cfb49799dd29451e885d14b.json"}}], "type": "journal article", "published": "2022-01-06", "journal": {"title": "JMIR Form Res", "issn": "2561-326X", "volume": "6", "issue": "1", "pages": "e27418", "issn-l": null}, "abstract": "Wearable devices can diagnose, monitor, and manage neurological disorders such as Parkinson disease. With a growing number of wearable devices, it is no longer a case of whether a wearable device can measure Parkinson disease motor symptoms, but rather which features suit the user. Concurrent with continued device development, it is important to generate insights on the nuanced needs of the user in the modern era of wearable device capabilities.\n\nThis study aims to understand the views and needs of people with Parkinson disease regarding wearable devices for disease monitoring and management.\n\nThis study used a mixed method parallel design, wherein survey and focus groups were concurrently conducted with people living with Parkinson disease in Munster, Ireland. Surveys and focus group schedules were developed with input from people with Parkinson disease. The survey included questions about technology use, wearable device knowledge, and Likert items about potential device features and capabilities. The focus group participants were purposively sampled for variation in age (all were aged >50 years) and sex. The discussions concerned user priorities, perceived benefits of wearable devices, and preferred features. Simple descriptive statistics represented the survey data. The focus groups analyzed common themes using a qualitative thematic approach. The survey and focus group analyses occurred separately, and results were evaluated using a narrative approach.\n\nOverall, 32 surveys were completed by individuals with Parkinson disease. Four semistructured focus groups were held with 24 people with Parkinson disease. Overall, the participants were positive about wearable devices and their perceived benefits in the management of symptoms, especially those of motor dexterity. Wearable devices should demonstrate clinical usefulness and be user-friendly and comfortable. Participants tended to see wearable devices mainly in providing data for health care professionals rather than providing feedback for themselves, although this was also important. Barriers to use included poor hand function, average technology confidence, and potential costs. It was felt that wearable device design that considered the user would ensure better compliance and adoption.\n\nWearable devices that allow remote monitoring and assessment could improve health care access for patients living remotely or are unable to travel. COVID-19 has increased the use of remotely delivered health care; therefore, future integration of technology with health care will be crucial. Wearable device designers should be aware of the variability in Parkinson disease symptoms and the unique needs of users. Special consideration should be given to Parkinson disease-related health barriers and the users' confidence with technology. In this context, a user-centered design approach that includes people with Parkinson disease in the design of technology will likely be rewarded with improved user engagement and the adoption of and compliance with wearable devices, potentially leading to more accurate disease management, including self-management.", "doi": "10.2196/27418", "pmid": "34989693", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "v6i1e27418"}], "notes": [], "created": "2022-01-10T15:33:59.352Z", "modified": "2022-01-10T15:33:59.759Z"}, {"entity": "publication", "iuid": "9600647319b848768a61f3a666f9c5b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9600647319b848768a61f3a666f9c5b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9600647319b848768a61f3a666f9c5b4"}}, "title": "Quality of training in cervical cancer radical surgery: a survey from the European Network of Young Gynaecologic Oncologists (ENYGO).", "authors": [{"family": "Bizzarri", "given": "Nicol\u00f2", "initials": "N", "orcid": "0000-0002-1727-904X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e74a49b3221461d87f46384492b5b7f.json"}}, {"family": "Pletnev", "given": "Andrei", "initials": "A"}, {"family": "Razumova", "given": "Zoia", "initials": "Z", "orcid": "0000-0001-6598-0896", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f9dd79d57f44a0ab455974d84356528.json"}}, {"family": "Zalewski", "given": "Kamil", "initials": "K"}, {"family": "Theofanakis", "given": "Charalampos", "initials": "C"}, {"family": "Selcuk", "given": "Ilker", "initials": "I"}, {"family": "Nikolova", "given": "Tanja", "initials": "T"}, {"family": "Lanner", "given": "Maximilian", "initials": "M"}, {"family": "G\u00f3mez-Hidalgo", "given": "Natalia R", "initials": "NR", "orcid": "0000-0003-3217-0453", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f3834258eca4d02b3825b5921e452b1.json"}}, {"family": "Kacperczyk-Bartnik", "given": "Joanna", "initials": "J", "orcid": "0000-0003-2539-3894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/471ce2b6e21949a4bcaa0b1aee57d217.json"}}, {"family": "Querleu", "given": "Denis", "initials": "D", "orcid": "0000-0002-3984-4812", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3971070784b9412995250d8c87ebcc27.json"}}, {"family": "Cibula", "given": "David", "initials": "D"}, {"family": "Verheijen", "given": "Ren\u00e9 H M", "initials": "RHM"}, {"family": "Fagotti", "given": "Anna", "initials": "A", "orcid": "0000-0001-5579-335X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd97a1bb600c43b4a47b2080ea6a4438.json"}}], "type": "journal article", "published": "2022-01-06", "journal": {"title": "Int J Gynecol Cancer", "issn": "1525-1438", "issn-l": null}, "abstract": "The European Society of Gynaecological Oncology (ESGO) and partners are committed to improving the training for gynecologic oncology fellows. The aim of this survey was to assess the type and level of training in cervical cancer surgery and to investigate whether the Laparoscopic Approach to Cervical Cancer (LACC) trial results impacted training in radical surgery for gynecologic oncology fellows.\n\nIn June 2020, a 47-question electronic survey was shared with European Network of Young Gynaecologic Oncologists (ENYGO) members. Specialist fellows in obstetrics and gynecology, and gynecologic oncology, from high- and low-volume centers, who started training between January 1, 2017 and January 1, 2020 or started before January 1, 2017 but finished their training at least 6 months after the LACC trial publication (October 2018), were included.\n\n81 of 125 (64.8%) respondents were included. The median time from the start of the fellowship to completion of the survey was 28 months (range 6-48). 56 (69.1%) respondents were still fellows-in-training. 6 of 56 (10.7%) and 14 of 25 (56.0%) respondents who were still in training and completed the fellowship, respectively, performed \u226510 radical hysterectomies during their training. Fellows trained in an ESGO accredited center had a higher chance to perform sentinel lymph node biopsy (60.4% vs 30.3%; p=0.027). There was no difference in the mean number of radical hysterectomies performed by fellows during fellowship before and after the LACC trial publication (8\u00b112.0 vs 7\u00b18.4, respectively; p=0.46). A significant reduction in number of minimally invasive radical hysterectomies was noted when comparing the period before and after the LACC trial (38.5% vs 13.8%, respectively; p<0.001).\n\nExposure to radical surgery for cervical cancer among gynecologic oncology fellows is low. Centralization of cervical cancer cases to high-volume centers may provide an increase in fellows' exposure to radical procedures. The LACC trial publication was associated with a decrease in minimally invasive radical hysterectomies performed by fellows.", "doi": "10.1136/ijgc-2021-002812", "pmid": "34992130", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijgc-2021-002812"}], "notes": [], "created": "2022-01-10T15:31:46.177Z", "modified": "2022-01-10T15:31:46.351Z"}, {"entity": "publication", "iuid": "13d86c561e5a47a79c5193613849a726", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13d86c561e5a47a79c5193613849a726.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13d86c561e5a47a79c5193613849a726"}}, "title": "Psychometric properties of the Fear of COVID-19 Scale: A response to de Medeiros et al. \"Psychometric properties of the Brazilian version of the Fear of COVID-19 Scale (FCV-19S)\".", "authors": [{"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "editorial", "published": "2022-01-06", "journal": {"title": "Curr Psychol", "issn": "1046-1310", "pages": "1-2", "issn-l": null}, "abstract": null, "doi": "10.1007/s12144-021-02686-4", "pmid": "35018078", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "2686"}, {"db": "pmc", "key": "PMC8734124"}], "notes": [], "created": "2022-01-13T21:00:30.676Z", "modified": "2022-01-13T21:00:30.690Z"}, {"entity": "publication", "iuid": "5099542421be45c89ca7a6a5f7f92733", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5099542421be45c89ca7a6a5f7f92733.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5099542421be45c89ca7a6a5f7f92733"}}, "title": "Is There a Link between COVID-19 and Periodontal Disease? A Narrative Review.", "authors": [{"family": "Grigoriadis", "given": "Andreas", "initials": "A", "orcid": "0000-0002-5542-2230", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2031eae513c4a7fa7e10c3bffa33683.json"}}, {"family": "R\u00e4is\u00e4nen", "given": "Ismo T", "initials": "IT"}, {"family": "P\u00e4rn\u00e4nen", "given": "Pirjo", "initials": "P"}, {"family": "Tervahartiala", "given": "Taina", "initials": "T"}, {"family": "Sorsa", "given": "Timo", "initials": "T"}, {"family": "Sakellari", "given": "Dimitra", "initials": "D"}], "type": "journal article", "published": "2022-01-06", "journal": {"title": "Eur J Dent", "issn": "1305-7456", "issn-l": null}, "abstract": "The coronavirus disease-2019 (COVID-19) pandemic greatly affected human well-being, social behavior, global economy, and healthcare systems. Everyday clinical practice in dentistry has been adjusted to the increased hazards of aerosol production by routine dental procedures. The objective of this study was to assess the existing literature to determine possible mechanisms of a relationship between COVID-19 and periodontitis, as well as describe findings from relevant epidemiological studies.Scarce data exist in the literature that directly addresses the relationship between the two diseases. However, several data describe the role of the oral cavity and periodontal tissues as portals of entry of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), and the contribution of cytokines known to be produced in periodontal disease to severe forms of COVID-19. It is also suggested from the current literature that periodontal disease, shown to be associated with systemic diseases such as diabetes mellitus, cardiovascular and respiratory diseases, shares common risk factors with-especially-severe forms of COVID-19.Further clinical studies are required to establish the relationship between these diseases. Oral hygiene performance and intact periodontal tissues can assist in mitigating the pandemic, and it is suggested that dental practitioners can contribute to identifying at-risk patients.", "doi": "10.1055/s-0041-1740223", "pmid": "34991165", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2022-01-10T15:32:00.493Z", "modified": "2022-01-10T15:33:01.416Z"}, {"entity": "publication", "iuid": "96f60f2aefe946beb5a0066138f3fcea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/96f60f2aefe946beb5a0066138f3fcea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/96f60f2aefe946beb5a0066138f3fcea"}}, "title": "Towards an optimal monoclonal antibody with higher binding affinity to the receptor-binding domain of SARS-CoV-2 spike proteins from different variants", "authors": [{"family": "Neamtu", "given": "Andrei", "initials": "A"}, {"family": "Mocci", "given": "Francesca", "initials": "F", "orcid": "0000-0003-1394-9146", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c727688989c44760a562f662759e9159.json"}}, {"family": "Laaksonen", "given": "Aatto", "initials": "A", "orcid": "0000-0001-9783-4535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3643d2a0d8094741960ef22c433ef52e.json"}}, {"family": "Barroso da Silva", "given": "Fernando L", "initials": "FL", "orcid": "0000-0003-2526-2085", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af9b9974afba4701b8c4875200458c79.json"}}], "type": "posted-content", "published": "2022-01-05", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.01.04.474958", "pmid": null, "labels": {"Category: Omicron VoC": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2022-01-21T16:20:52.980Z", "modified": "2022-01-21T16:22:00.578Z"}, {"entity": "publication", "iuid": "0c1b1ad99f3b44578c6c0520a8c6816e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c1b1ad99f3b44578c6c0520a8c6816e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c1b1ad99f3b44578c6c0520a8c6816e"}}, "title": "The ratio of cardiac troponin T to troponin I may indicate non-necrotic troponin release among COVID-19 patients.", "authors": [{"family": "Hammarsten", "given": "Ola", "initials": "O"}, {"family": "Ljungqvist", "given": "Pontus", "initials": "P"}, {"family": "Redfors", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Wernbom", "given": "Mathias", "initials": "M"}, {"family": "Widing", "given": "Hannes", "initials": "H"}, {"family": "Lindahl", "given": "Bertil", "initials": "B"}, {"family": "Salahuddin", "given": "Sabin", "initials": "S"}, {"family": "Sammantar", "given": "Ruwayda", "initials": "R"}, {"family": "Jha", "given": "Sandeep", "initials": "S"}, {"family": "Ravn-Fischer", "given": "Annica", "initials": "A"}, {"family": "Brink", "given": "Magnus", "initials": "M"}, {"family": "Gisslen", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2022-01-05", "journal": {"title": "Clin Chim Acta", "issn": "1873-3492", "issn-l": "0009-8981", "volume": "527", "issue": null, "pages": "33-37"}, "abstract": "Although cardiac troponin T (cTnT) and troponin I(cTnI) are expressed to similar amount in cardiac tissue, cTnI often reach ten-times higher peak levels compared to cTnT in patients with myocardial necrosis such as in acute myocardial infarction (MI). In contrast, similar levels of cTnT and cTnI are observed in other situations such as stable atrial fibrillation and after strenuous exercise.\n\nExamine cTnT and cTnI levels in relation to COVID-19 disease and MI.\n\nClinical and laboratory data from the local hospital from an observational cohort study of 27 patients admitted with COVID-19 and 15 patients with myocardial infarction (MI) that were analyzed with paired cTnT and cTnI measurement during hospital care.\n\nLevels of cTnI were lower than cTnT in COVID-19 patients (TnI/TnT ratio 0.3, IQR: 0.1-0.6). In contrast, levels of cTnI were 11 times higher compared to cTnT in 15 patients with MI (TnI/TnT ratio 11, IQR: 7-14). The peak cTnI/cTnT ratio among the patients with MI following successful percutaneous intervention were 14 (TnI/TnT ratio 14, IQR: 12-23). The 5 COVID-19 patient samples collected under possible necrotic events had a cTnI/cTnT ratio of 5,5 (IQR: 1,9-8,3).\n\nIn patients with COVID-19, cTnT is often elevated to higher levels than cTnI in sharp contrast to patients with MI, indicating that the release of cardiac troponin has a different cause in COVID-19 patients.", "doi": "10.1016/j.cca.2021.12.030", "pmid": "34998858", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S0009-8981(21)00459-9"}, {"db": "pmc", "key": "PMC8744390"}], "notes": [], "created": "2022-01-10T11:51:34.183Z", "modified": "2022-02-06T17:33:39.186Z"}, {"entity": "publication", "iuid": "816288de60f1430e94cf34b9fe9c777c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/816288de60f1430e94cf34b9fe9c777c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/816288de60f1430e94cf34b9fe9c777c"}}, "title": "Psychometric evaluation of fear of COVID-19 Scale (FCV-19S) among Chinese primary and middle schoolteachers, and their students.", "authors": [{"family": "Chen", "given": "I-Hua", "initials": "IH"}, {"family": "Chen", "given": "Chao-Ying", "initials": "CY"}, {"family": "Zhao", "given": "Ke-Yun", "initials": "KY"}, {"family": "Gamble", "given": "Jeffrey H", "initials": "JH"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2022-01-05", "journal": {"title": "Curr Psychol", "issn": "1046-1310", "pages": "1-17", "issn-l": null}, "abstract": "Utilizing a large-scale cross-sectional survey, the present study tested the advanced psychometric properties of Fear of COVID-19 Scale (FCV-19S) in specific populations (i.e., primary and middle schoolteachers, and their students). The present study also examined the association between perceived fear of COVID-19 and psychological distress among home-room teachers (i.e., teachers who teach all their students in one classroom all day) and their students. The results among participants (11,134 teachers and 4,335 students) indicated good internal reliability of FCV-19S and excellent factorial validity with a two-factor structure utilizing these specific populations. Furthermore, the multilevel analysis showed that home-room teachers' psychological distress, but not fear of COVID-19, was positively associated with their students. In sum, the FCV-19S is a useful tool to assess the fear of COVID-19 on potentially vulnerable populations (i.e., primary/middle schoolteachers and their students). Future studies are encouraged to use the present study's findings to investigate possible underlying mechanisms for developing effective coping strategies and interventions.\n\nThe online version contains supplementary material available at 10.1007/s12144-021-02471-3.", "doi": "10.1007/s12144-021-02471-3", "pmid": "35002189", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2471"}, {"db": "pmc", "key": "PMC8727075"}], "notes": [], "created": "2022-01-13T21:11:56.448Z", "modified": "2022-01-13T21:11:56.494Z"}, {"entity": "publication", "iuid": "8f35ecffb0674516a54335b722d34bc9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f35ecffb0674516a54335b722d34bc9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f35ecffb0674516a54335b722d34bc9"}}, "title": "Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16.", "authors": [{"family": "Kozielski", "given": "Frank", "initials": "F"}, {"family": "Sele", "given": "C\u00e9leste", "initials": "C"}, {"family": "Talibov", "given": "Vladimir O", "initials": "VO"}, {"family": "Lou", "given": "Jiaqi", "initials": "J"}, {"family": "Dong", "given": "Danni", "initials": "D"}, {"family": "Wang", "given": "Qian", "initials": "Q"}, {"family": "Shi", "given": "Xinyue", "initials": "X"}, {"family": "Nyblom", "given": "Maria", "initials": "M"}, {"family": "Rogstam", "given": "Annika", "initials": "A"}, {"family": "Krojer", "given": "Tobias", "initials": "T"}, {"family": "Fisher", "given": "Zo\u00eb", "initials": "Z", "orcid": "0000-0001-8287-0269", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84513a785fda44798344a51a5c960ff7.json"}}, {"family": "Knecht", "given": "Wolfgang", "initials": "W", "orcid": "0000-0001-9530-7598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/034349dc8d0a404c9ecb0fa6cb63b44d.json"}}], "type": "journal article", "published": "2022-01-05", "journal": {"title": "RSC Chem Biol", "issn": "2633-0679", "volume": "3", "issue": "1", "pages": "44-55", "issn-l": null}, "abstract": "Since the emergence of SARS-CoV-2 in 2019, Covid-19 has developed into a serious threat to our health, social and economic systems. Although vaccines have been developed in a tour-de-force and are now increasingly available, repurposing of existing drugs has been less successful. There is a clear need to develop new drugs against SARS-CoV-2 that can also be used against future coronavirus infections. Non-structural protein 10 (nsp10) is a conserved stimulator of two enzymes crucial for viral replication, nsp14 and nsp16, exhibiting exoribonuclease and methyltransferase activities. Interfering with RNA proofreading or RNA cap formation represents intervention strategies to inhibit replication. We applied fragment-based screening using nano differential scanning fluorometry and X-ray crystallography to identify ligands targeting SARS-CoV-2 nsp10. We identified four fragments located in two distinct sites: one can be modelled to where it would be located in the nsp14-nsp10 complex interface and the other in the nsp16-nsp10 complex interface. Microscale thermophoresis (MST) experiments were used to quantify fragment affinities for nsp10. Additionally, we showed by MST that the interaction by nsp14 and 10 is weak and thereby that complex formation could be disrupted by small molecules. The fragments will serve as starting points for the development of more potent analogues using fragment growing techniques and structure-based drug design.", "doi": "10.1039/d1cb00135c", "pmid": "35128408", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "d1cb00135c"}, {"db": "pmc", "key": "PMC8729259"}, {"db": "URL", "key": "https://www.rcsb.org/structure/7ORR", "description": "https://www.rcsb.org/structure/7ORR"}, {"db": "URL", "key": "https://www.rcsb.org/structure/7ORU", "description": "https://www.rcsb.org/structure/7ORU"}, {"db": "URL", "key": "https://www.rcsb.org/structure/7ORW", "description": "https://www.rcsb.org/structure/7ORW"}, {"db": "URL", "key": "https://www.rcsb.org/structure/7ORV", "description": "https://www.rcsb.org/structure/7ORV"}, {"db": "URL", "key": "https://zenodo.org/record/5234009#.Ygzu4d_TVBw", "description": "https://zenodo.org/record/5234009#.Ygzu4d_TVBw"}], "notes": [], "created": "2022-02-08T15:12:57.601Z", "modified": "2022-02-16T14:45:03.822Z"}, {"entity": "publication", "iuid": "f5e4a19529c9460db484bb7110e5b52b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f5e4a19529c9460db484bb7110e5b52b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f5e4a19529c9460db484bb7110e5b52b"}}, "title": "Heterologous immunization with inactivated vaccine followed by mRNA booster elicits strong humoral and cellular immune responses against the SARS-CoV-2 Omicron variant", "authors": [{"family": "Zuo", "given": "Fanglei", "initials": "F"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Piralla", "given": "Antonio", "initials": "A"}, {"family": "Bertoglio", "given": "Federico", "initials": "F"}, {"family": "de Campos-Mata", "given": "Leire", "initials": "L"}, {"family": "Wan", "given": "Hui", "initials": "H"}, {"family": "Schubert", "given": "Maren", "initials": "M"}, {"family": "Wang", "given": "Yating", "initials": "Y"}, {"family": "Sun", "given": "Rui", "initials": "R"}, {"family": "Cassaniti", "given": "Irene", "initials": "I"}, {"family": "Vlachiotis", "given": "Stelios", "initials": "S"}, {"family": "Kumagai-Braesch", "given": "Makiko", "initials": "M"}, {"family": "Andr\u00e9ll", "given": "Juni", "initials": "J"}, {"family": "Zhang", "given": "Zhaoxia", "initials": "Z"}, {"family": "Xue", "given": "Yintong", "initials": "Y"}, {"family": "Wenzel", "given": "Esther Veronika", "initials": "EV"}, {"family": "Calzolai", "given": "Luigi", "initials": "L"}, {"family": "Varani", "given": "Luca", "initials": "L"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Chavoshzadeh", "given": "Zahra", "initials": "Z"}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Hust", "given": "Michael", "initials": "M", "orcid": "0000-0003-3418-6045", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0587ca1111f84a61aaf8917a123d49c1.json"}}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}], "type": "posted-content", "published": "2022-01-05", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.01.04.22268755", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Health": null, "Category: Omicron VoC": null}, "xrefs": [], "notes": [], "created": "2022-01-12T20:54:35.413Z", "modified": "2022-01-21T15:44:21.528Z"}, {"entity": "publication", "iuid": "c10a0714bf2a447fac79cff2efabad6c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c10a0714bf2a447fac79cff2efabad6c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c10a0714bf2a447fac79cff2efabad6c"}}, "title": "Suicidal Ideation during the COVID-19 Pandemic among A Large-Scale Iranian Sample: The Roles of Generalized Trust, Insomnia, and Fear of COVID-19.", "authors": [{"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Ehsani", "given": "Narges", "initials": "N"}, {"family": "Ohayon", "given": "Maurice M", "initials": "MM"}, {"family": "Chen", "given": "Shun-Hua", "initials": "SH", "orcid": "0000-0002-6158-5829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22cb281a4d004f29ad4c944f1f6c344c.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2022-01-04", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "volume": "10", "issue": "1", "issn-l": null}, "abstract": "The novel 2019 coronavirus disease (COVID-19) is still not under control globally. The pandemic has caused mental health issues among many different cohorts and suicidal ideation in relation to COVID-19 has been reported in a number of recent studies. Therefore, the present study proposed a model to explain the associations between generalized trust, fear of COVID-19, insomnia, and suicidal ideation during the COVID-19 pandemic among a large-scale Iranian sample. Utilizing cluster sampling with multistage stratification, residents from Qazvin province in Iran were invited to participate in the present study. Adults aged over 18 years (n = 10,843; 6751 [62.3%] females) completed 'paper-and-pencil' questionnaires with the assistance of a trained research assistant. Structural equation modeling (SEM) was applied to understand the associations between generalized trust, fear of COVID-19, insomnia, and suicidal ideation. Slightly over one-fifth of the participants (n = 2252; 20.8%) reported suicidal ideation. Moreover, the SEM results indicated that generalized trust was indirectly associated with suicidal ideation via fear of COVID-19 and insomnia. Furthermore, generalized trust was not directly associated with suicidal ideation. The proposed model was invariant across gender groups, age groups, and participants residing in different areas (i.e., urban vs. rural). Generalized trust might reduce individuals' suicidal ideation during the COVID-19 pandemic period via reduced levels of fear of COVID-19 and insomnia. Healthcare providers and policymakers may want to assist individuals in developing their generalized trust, reducing fear of COVID-19, and improving insomnia problems to avoid possible suicidal behaviors.", "doi": "10.3390/healthcare10010093", "pmid": "35052258", "labels": {"Category: Public Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "healthcare10010093"}], "notes": [], "created": "2022-01-26T10:24:50.075Z", "modified": "2022-01-26T10:24:50.163Z"}, {"entity": "publication", "iuid": "85f1e00155fd49f48d305e0694acae51", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/85f1e00155fd49f48d305e0694acae51.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/85f1e00155fd49f48d305e0694acae51"}}, "title": "Structural basis of Omicron neutralization by affinity-matured public antibodies", "authors": [{"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Pushparaj", "given": "Pradeepa", "initials": "P"}, {"family": "Das", "given": "Hrishikesh", "initials": "H"}, {"family": "Kim", "given": "Changil", "initials": "C"}, {"family": "Kim", "given": "Sungyong", "initials": "S"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Dyrdak", "given": "Robert", "initials": "R", "orcid": "0000-0001-8456-4898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98ad76a0e144478cb3ceabd05c9928b0.json"}}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "H\u00e4llberg", "given": "B Martin", "initials": "BM", "orcid": "0000-0002-6781-0345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea241fd233ca40a6be4ffa1472d2aa06.json"}}], "type": "posted-content", "published": "2022-01-04", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.01.03.474825", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Health": null, "Category: Omicron VoC": null}, "xrefs": [], "notes": [], "created": "2022-01-12T20:56:05.166Z", "modified": "2023-06-19T14:45:01.436Z"}, {"entity": "publication", "iuid": "1731370beba149bda4ea02b21c210e81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1731370beba149bda4ea02b21c210e81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1731370beba149bda4ea02b21c210e81"}}, "title": "Informal caregiver support needs and burden: a survey in Lithuania.", "authors": [{"family": "Biliunaite", "given": "Ieva", "initials": "I", "orcid": "0000-0002-9111-0891", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51a4248a3ff9484bbc49137b51d2f71a.json"}}, {"family": "Kazlauskas", "given": "Evaldas", "initials": "E", "orcid": "0000-0002-6654-6220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/325ffed05ee04a7fb3aefc3dd9e168e1.json"}}, {"family": "Sanderman", "given": "Robbert", "initials": "R"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}], "type": "journal article", "published": "2022-01-04", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "1", "pages": "e054607", "issn-l": "2044-6055"}, "abstract": "A demand for informal care exists worldwide. Lithuania presents an interesting case example where the need for the informal care is increasing, but relatively little research has been conducted documenting caregivers' experiences and needs.\n\nThe main objective of this study was to investigate Lithuanian informal caregiver characteristics, support needs and burden. In addition, the impact of the COVID-19 on the caregiver's and care receiver's well-being was investigated.\n\nThe study was conducted online between May and September 2020. Informal caregivers and individuals with informal caregiving experiences were invited to participate in the survey. The survey questionnaire comprised 38 multiple-choice items including participant demographic characteristics, availability of the support, support needs, well-being and the impact of the COVID-19 pandemic. In addition, caregiver burden was assessed with the 24-item Caregiver Burden Inventory (CBI).\n\nA total of 226 individuals completed the survey. Most of the participants were women (87.6%). Almost half of the participants (48.7%) were not receiving any support, and a total of 73.9% expressed a need to receive more professional support. Participants were found to experience high burden on the CBI (M=50.21, SD=15.63). Women were found to be significantly more burdened than men (p=0.011). Even though many participants experienced psychological problems (55.8%), only 2.2% were receiving any psychological support. Finally, majority of the participants did not experience any changes in their own (63.7%) or the well-being of their care receiver (68.1%) due to the COVID-19 pandemic.\n\nMost of the participants were identified as intensive caregivers experiencing a high burden. A majority did not experience changes in their well-being due to COVID-19. We propose several recommendations for increasing accessibility and availability of support for informal caregivers in Lithuania based on the study findings.", "doi": "10.1136/bmjopen-2021-054607", "pmid": "34983768", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-054607"}], "notes": [], "created": "2022-01-10T15:42:11.114Z", "modified": "2022-01-10T15:42:27.894Z"}, {"entity": "publication", "iuid": "73e04d2e08b24dcb8c8839169bb1d85b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/73e04d2e08b24dcb8c8839169bb1d85b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/73e04d2e08b24dcb8c8839169bb1d85b"}}, "title": "Evidence of Air and Surface Contamination with SARS-CoV-2 in a Major Hospital in Portugal.", "authors": [{"family": "Silva", "given": "Priscilla Gomes da", "initials": "PGD"}, {"family": "Gon\u00e7alves", "given": "Jos\u00e9", "initials": "J", "orcid": "0000-0003-2191-527X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7bc13d9c6bec4167aca395c18335bae8.json"}}, {"family": "Lopes", "given": "Ariana Isabel Brito", "initials": "AIB"}, {"family": "Esteves", "given": "Nury Alves", "initials": "NA"}, {"family": "Bamba", "given": "Gustavo Emanuel Enes", "initials": "GEE"}, {"family": "Nascimento", "given": "Maria S\u00e3o Jos\u00e9", "initials": "MSJ", "orcid": "0000-0002-6157-4978", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54388d9b1cc447168086583c0ef4f9a5.json"}}, {"family": "Branco", "given": "Pedro T B S", "initials": "PTBS", "orcid": "0000-0002-4163-0936", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b0c4d92fbc947a2b280ab17a64e9247.json"}}, {"family": "Soares", "given": "Ruben R G", "initials": "RRG", "orcid": "0000-0001-5958-5232", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2fc2815bc25c4fb78df63294947ee184.json"}}, {"family": "Sousa", "given": "Sofia I V", "initials": "SIV", "orcid": "0000-0002-4139-673X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f368cca1ed2144718a95ef3632ba7b3a.json"}}, {"family": "Mesquita", "given": "Jo\u00e3o R", "initials": "JR", "orcid": "0000-0001-8769-8103", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/233b221fd5d7472fab41c89a19beadd5.json"}}], "type": "journal article", "published": "2022-01-04", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "1", "issn-l": null}, "abstract": "As the third wave of the COVID-19 pandemic hit Portugal, it forced the country to reintroduce lockdown measures due to hospitals reaching their full capacities. Under these circumstances, environmental contamination by SARS-CoV-2 in different areas of one of Portugal's major Hospitals was assessed between 21 January and 11 February 2021. Air samples (n = 44) were collected from eleven different areas of the Hospital (four COVID-19 and seven non-COVID-19 areas) using Coriolis\u00ae \u03bc and Coriolis\u00ae Compact cyclone air sampling devices. Surface sampling was also performed (n = 17) on four areas (one COVID-19 and three non-COVID-19 areas). RNA extraction followed by a one-step RT-qPCR adapted for quantitative purposes were performed. Of the 44 air samples, two were positive for SARS-CoV-2 RNA (6575 copies/m3 and 6662.5 copies/m3, respectively). Of the 17 surface samples, three were positive for SARS-CoV-2 RNA (200.6 copies/cm2, 179.2 copies/cm2, and 201.7 copies/cm2, respectively). SARS-CoV-2 environmental contamination was found both in air and on surfaces in both COVID-19 and non-COVID-19 areas. Moreover, our results suggest that longer collection sessions are needed to detect point contaminations. This reinforces the need to remain cautious at all times, not only when in close contact with infected individuals. Hand hygiene and other standard transmission-prevention guidelines should be continuously followed to avoid nosocomial COVID-19.", "doi": "10.3390/ijerph19010525", "pmid": "35010785", "labels": {"Category: Other": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph19010525"}], "notes": [], "created": "2022-01-13T21:07:50.384Z", "modified": "2022-01-13T21:07:59.578Z"}, {"entity": "publication", "iuid": "6229e6d010c64da2802a196b60b10ea9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6229e6d010c64da2802a196b60b10ea9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6229e6d010c64da2802a196b60b10ea9"}}, "title": "Scaling the Children Immunization App (CIMA) to Support Child Refugees and Parents in the Time of the COVID-19 Pandemic: A Social Capital Approach to Scale a Smartphone Application in Zaatari Camp, Jordan.", "authors": [{"family": "Khader", "given": "Yousef S", "initials": "YS"}, {"family": "Maalouf", "given": "Wadih", "initials": "W"}, {"family": "Khdair", "given": "Mohammad Abu", "initials": "MA"}, {"family": "Al-Nsour", "given": "Mohannad", "initials": "M"}, {"family": "Aga", "given": "Eresso", "initials": "E"}, {"family": "Khalifa", "given": "Adam", "initials": "A"}, {"family": "Kassasbeh", "given": "Mohamad", "initials": "M"}, {"family": "El-Halabi", "given": "Soha", "initials": "S"}, {"family": "Alfven", "given": "Tobias", "initials": "T"}, {"family": "El-Khatib", "given": "Ziad", "initials": "Z", "orcid": "0000-0003-0756-7280", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31747e0476314de9bf53d8c8f3d1d147.json"}}], "type": "journal article", "published": "2022-01-03", "journal": {"title": "J Epidemiol Glob Health", "issn": "2210-6014", "issn-l": null}, "abstract": "Children vaccination is a key intervention for their survival, especially among refugees. Yet, children vaccination registration is done manually in refugees camps and there is no possibility to send reminders to parents to come back on time. We aimed to boost the parental registration of children's vaccination records on a Children Immunization app (CIMA) while also availing the parents with useful parenting skills under COVID-19-related stress.\n\nWe incorporated United Nations Office on Drugs and Crime (UNODC) Parenting Skills under COVID-19 information material, through CIMA in Arabic and English languages. We recruited 1100 children in February-March 2021, through a community health promotion dissemination approach. A team of two nurses from the local population and two volunteers (one trained nurse and one trained social worker), from the camp, was formed. They promoted the CIMA app at two clinics and through households visits in Zaatari refugee camp. Qualitative data on impressions and observations of the interactions with the Zaatari camp community were also collected.\n\nA total of 1100 children, up to 15 months of age, eligible for vaccination were enrolled in CIMA, whereby the staff explained the content of the app in terms of vaccination schedule, health promotion materials for vaccination and parenting skills to their caregivers. During the household visits, the volunteers identified a total of 70 children that have incomplete history of vaccination records (n = 42/70 girls, 60%). Also, opportunities and challenges for scaling the app were documented.\n\nThe scaling of CIMA as an innovative means of dissemination of risk and health information in challenging context such as refugee camps was feasible. In the context of vaccination needs for children, in refugee settings, such a need is more eminent, particularly in the context of COVID-19.", "doi": "10.1007/s44197-021-00029-x", "pmid": "34978708", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s44197-021-00029-x"}, {"db": "pmc", "key": "PMC8721635"}], "notes": [], "created": "2022-01-04T14:43:02.544Z", "modified": "2022-01-10T15:43:57.754Z"}, {"entity": "publication", "iuid": "790d80d81559486d90955b9d06bec5fb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/790d80d81559486d90955b9d06bec5fb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/790d80d81559486d90955b9d06bec5fb"}}, "title": "COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease - 3rd CIAO AOP Design Workshop.", "authors": [{"family": "Clerbaux", "given": "Laure-Alix", "initials": "LA"}, {"family": "Amig\u00f3", "given": "N\u00faria", "initials": "N"}, {"family": "Amorim", "given": "Maria Jo\u00e3o", "initials": "MJ"}, {"family": "Bal-Price", "given": "Anna", "initials": "A"}, {"family": "Batista Leite", "given": "Sofia", "initials": "S"}, {"family": "Beronius", "given": "Anna", "initials": "A"}, {"family": "Bezemer", "given": "Gillina F G", "initials": "GFG"}, {"family": "Bostroem", "given": "Ann-Charlotte", "initials": "AC"}, {"family": "Carusi", "given": "Annamaria", "initials": "A"}, {"family": "Coecke", "given": "Sandra", "initials": "S"}, {"family": "Concha", "given": "Rachel", "initials": "R"}, {"family": "Daskalopoulos", "given": "Evangelos P", "initials": "EP"}, {"family": "Debernardi", "given": "Francesca", "initials": "F"}, {"family": "Edrosa", "given": "Eizleayne", "initials": "E"}, {"family": "Edwards", "given": "Steve W", "initials": "SW"}, {"family": "Filipovska", "given": "Julija", "initials": "J"}, {"family": "Garcia-Reyero", "given": "Nat\u00e0lia", "initials": "N"}, {"family": "Gavins", "given": "Felicity N E", "initials": "FNE"}, {"family": "Halappanavar", "given": "Sabina", "initials": "S"}, {"family": "Hargreaves", "given": "Alan J", "initials": "AJ"}, {"family": "Hogberg", "given": "Helena T", "initials": "HT"}, {"family": "Huynh", "given": "Myl\u00e8ne T", "initials": "MT"}, {"family": "Jacobson", "given": "Daniel", "initials": "D"}, {"family": "Josephs-Spaulding", "given": "Jonathan", "initials": "J"}, {"family": "Kim", "given": "Young Jun", "initials": "YJ"}, {"family": "Kong", "given": "Hyun Joon", "initials": "HJ"}, {"family": "Krebs", "given": "Catharine E", "initials": "CE"}, {"family": "Lam", "given": "Ann", "initials": "A"}, {"family": "Landesmann", "given": "Brigitte", "initials": "B"}, {"family": "Layton", "given": "Adrienne", "initials": "A"}, {"family": "Lee", "given": "Yong Oh", "initials": "YO"}, {"family": "Macmillan", "given": "Donna S", "initials": "DS"}, {"family": "Mantovani", "given": "Alberto", "initials": "A"}, {"family": "Margiotta-Casaluci", "given": "Luigi", "initials": "L"}, {"family": "Martens", "given": "Marvin", "initials": "M"}, {"family": "Masereeuw", "given": "Rosalinde", "initials": "R"}, {"family": "Mayasich", "given": "Sally A", "initials": "SA"}, {"family": "Mei", "given": "Liang Merlin", "initials": "LM"}, {"family": "Mortensen", "given": "Holly", "initials": "H"}, {"family": "Munoz Pineiro", "given": "Amalia", "initials": "A"}, {"family": "Nymark", "given": "Penny", "initials": "P"}, {"family": "Ohayon", "given": "Elan", "initials": "E"}, {"family": "Ojasi", "given": "Joshi", "initials": "J"}, {"family": "Paini", "given": "Alicia", "initials": "A"}, {"family": "Parissis", "given": "Nikolaos", "initials": "N"}, {"family": "Parvatam", "given": "Surat", "initials": "S"}, {"family": "Pistollato", "given": "Francesca", "initials": "F"}, {"family": "Sachana", "given": "Magdalini", "initials": "M"}, {"family": "S\u00f8rli", "given": "Jorid Birkelund", "initials": "JB"}, {"family": "Sullivan", "given": "Kristie M", "initials": "KM"}, {"family": "Sund", "given": "Jukka", "initials": "J"}, {"family": "Tanabe", "given": "Shihori", "initials": "S"}, {"family": "Tsaioun", "given": "Katya", "initials": "K"}, {"family": "Vinken", "given": "Mathieu", "initials": "M"}, {"family": "Viviani", "given": "Laura", "initials": "L"}, {"family": "Waspe", "given": "Jennifer", "initials": "J"}, {"family": "Willett", "given": "Catherine", "initials": "C"}, {"family": "Wittwehr", "given": "Clemens", "initials": "C"}], "type": "editorial", "published": "2022-01-03", "journal": {"title": "ALTEX", "issn": "1868-596X", "issn-l": null}, "abstract": "On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO workshop. The CIAO project \"Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework\" aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological key events (KE) toward an adverse outcome, such as respiratory distress, anosmia or multiorgan failure. Assembling the individual AOPs into a network highlights shared KEs as central biological nodes involved in multiple outcomes observed in COVID-19 patients. During the workshop, the KEs and AOPs established so far by the CIAO members were presented and positioned on a timeline of the disease course. Modulating factors influencing the progression and severity of the disease were also addressed, as well as factors beyond purely biological phenomena. CIAO relies on an interdisciplinary crowdsourcing effort, therefore, approaches to expand the CIAO network by widening the crowd and reaching stakeholders were also discussed. To conclude the workshop, it was decided that the AOPs/KEs will be further consolidated, integrating viral variants and long COVID when relevant, while an outreach campaign will be launched to broaden the CIAO scientific crowd.", "doi": "10.14573/altex.2112161", "pmid": "35032963", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2022-01-27T08:01:19.129Z", "modified": "2022-01-27T08:01:19.141Z"}, {"entity": "publication", "iuid": "e8c30921f2d5452399e9ee79e9b6029c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e8c30921f2d5452399e9ee79e9b6029c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e8c30921f2d5452399e9ee79e9b6029c"}}, "title": "Inclusion of Essential Universal Health Coverage Services in Essential Packages of Health Services: A Review of 45 Low- and Lower- Middle Income Countries.", "authors": [{"family": "Shekh Mohamed", "given": "Idil", "initials": "I", "orcid": "0000-0001-8793-601X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/530ee0a9cc58442aafd51798fc54a8fe.json"}}, {"family": "Hepburn", "given": "Jasmine Sprague", "initials": "JS", "orcid": "0000-0002-0917-3181", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b48672dcc13b4596a58890e94992ffdf.json"}}, {"family": "Ekman", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0001-7630-7904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1f4d8ed39cc483a802c179c1f37c53d.json"}}, {"family": "Sundewall", "given": "Jesper", "initials": "J", "orcid": "0000-0001-5357-5754", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c5701bdabae44638729d729958821db.json"}}], "type": "journal article", "published": "2022-01-01", "journal": {"title": "Health Syst Reform", "issn": "2328-8620", "volume": "8", "issue": "1", "pages": "e2006587", "issn-l": null}, "abstract": "Expanding service coverage and achieving universal health coverage (UHC) is a priority for many low- and middle-income countries. Though UHC is a long-term goal, its importance and relevance have only increased since the start of the COVID-19 pandemic. The first step on the road to UHC is to define and develop essential packages of health services (EPHSs), a list of clinical and public health services that a government has deemed a priority and is to provide. However, the nature of these lists of services in low- and lower-middle-income countries is largely unknown. This study examines the contents of 45 countries' EPHSs to determine the inclusion of essential UHC (EUHC) services as defined by the Disease Control Priorities, which comprises 21 specific essential packages of interventions. EPHSs were collected from publicly available sources and their contents were analyzed in two stages, firstly, to determine the level of specificity and detail of the content of EPHSs and, secondly, to determine which essential UHC services were included. Findings show that there are large variations in the level of specificity among EPHSs and that though EUHC services are included to a large extent, variations exist regarding which services are included between countries. The results provide an overview of how countries are designing EPHSs as a policy tool and are progressing toward providing a full range of EUHC services. Additionally, the study introduces new tools and methods for UHC policy analysts and researchers to study the contents of EPHSs in future investigations.", "doi": "10.1080/23288604.2021.2006587", "pmid": "35060830", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2022-01-26T10:20:24.847Z", "modified": "2022-01-26T10:20:24.998Z"}, {"entity": "publication", "iuid": "255e08a4b562434cb10d5c4b99e40fbe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/255e08a4b562434cb10d5c4b99e40fbe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/255e08a4b562434cb10d5c4b99e40fbe"}}, "title": "COVID-19 Pulmonary Pathology: The Experience of European Pulmonary Pathologists throughout the First Two Waves of the Pandemic.", "authors": [{"family": "Fortarezza", "given": "Francesco", "initials": "F"}, {"family": "Pezzuto", "given": "Federica", "initials": "F", "orcid": "0000-0002-8023-3108", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f2021982e9bc4f2aa6c75fc8ea679bc5.json"}}, {"family": "Hofman", "given": "Paul", "initials": "P", "orcid": "0000-0003-0431-9353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80753da68c474a46a5fd85c76e468fdb.json"}}, {"family": "Kern", "given": "Izidor", "initials": "I"}, {"family": "Panizo", "given": "Angel", "initials": "A", "orcid": "0000-0001-8405-7378", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3510815aee214ab7bc89ac6ea9af60b6.json"}}, {"family": "von der Th\u00fcsen", "given": "Jan", "initials": "J", "orcid": "0000-0001-9699-4860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/703d4cdc0b10482391d986defbfe0b9a.json"}}, {"family": "Timofeev", "given": "Sergei", "initials": "S", "orcid": "0000-0002-7098-9024", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dbf89525c1b40ae968ebacad2cf26b8.json"}}, {"family": "Gorkiewicz", "given": "Gregor", "initials": "G", "orcid": "0000-0003-1149-4782", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7745a0222ee340a4897d7bd58f6d4e7f.json"}}, {"family": "Berezowska", "given": "Sabina", "initials": "S", "orcid": "0000-0001-5442-9791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61f52024cff94937b61c28841e8f9912.json"}}, {"family": "de Level", "given": "Laurence", "initials": "L", "orcid": "0000-0003-3994-516X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c0844df584e45b88b88f785e3e272cf.json"}}, {"family": "Ortiz-Villal\u00f3n", "given": "Cristian", "initials": "C"}, {"family": "Lunardi", "given": "Francesca", "initials": "F", "orcid": "0000-0001-5792-4683", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/702db0cd99754d57994f3a5f0e2beb4a.json"}}, {"family": "Calabrese", "given": "Fiorella", "initials": "F"}], "type": "journal article", "published": "2022-01-01", "journal": {"title": "Diagnostics (Basel)", "issn": "2075-4418", "volume": "12", "issue": "1", "issn-l": null}, "abstract": "Autoptic studies of patients who died from COVID-19 constitute an important step forward in improving our knowledge in the pathophysiology of SARS-CoV-2 infection. Systematic analyses of lung tissue, the organ primarily targeted by the disease, were mostly performed during the first wave of the pandemic. Analyses of pathological lesions at different times offer a good opportunity to better understand the disease and how its evolution has been influenced mostly by new SARS-CoV-2 variants or the different therapeutic approaches. In this short report we summarize responses collected from a questionnaire survey that investigated important pathological data during the first two pandemic waves (spring-summer 2020; autumn-winter 2020-2021). The survey was submitted to expert lung pathologists from nine European countries involved in autoptic procedures in both pandemic waves. The frequency of each lung lesion was quite heterogeneous among the participants. However, a higher frequency of pulmonary superinfections, both bacterial and especially fungal, was observed in the second wave compared to the first. Obtaining a deeper knowledge of the pathological lesions at the basis of this complex and severe disease, which change over time, is crucial for correct patient management and treatment. Autoptic examination is a useful tool to achieve this goal.", "doi": "10.3390/diagnostics12010095", "pmid": "35054262", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "diagnostics12010095"}], "notes": [], "created": "2022-01-26T10:21:31.500Z", "modified": "2022-01-26T10:21:31.796Z"}, {"entity": "publication", "iuid": "b7ee308346fa414fb9d99656c2200991", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b7ee308346fa414fb9d99656c2200991.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b7ee308346fa414fb9d99656c2200991"}}, "title": "Soluble TNF receptors predict acute kidney injury and mortality in critically ill COVID-19 patients: A prospective observational study", "authors": [{"family": "Sancho Ferrando", "given": "Elena", "initials": "E"}, {"family": "Hanslin", "given": "Katja", "initials": "K"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Larsson", "given": "Anders", "initials": "A", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2be858ab604743b72383dfdcd14689.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}], "type": "journal-article", "published": "2022-01-00", "journal": {"title": "Cytokine", "issn": "1043-4666", "issn-l": null, "volume": "149", "issue": null, "pages": "155727"}, "abstract": null, "doi": "10.1016/j.cyto.2021.155727", "pmid": "34628127", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:53:51.144Z", "modified": "2022-02-15T08:24:46.792Z"}, {"entity": "publication", "iuid": "036acb2ce314488696558f11b81b706b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/036acb2ce314488696558f11b81b706b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/036acb2ce314488696558f11b81b706b"}}, "title": "Salivary IgG to SARS-CoV-2 indicates seroconversion and correlates to serum neutralization in mRNA-vaccinated immunocompromised individuals", "authors": [{"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "Pin", "given": "Elisa", "initials": "E", "orcid": "0000-0002-2158-2674", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5568b1a9e3c456c8ee4a95eaa55b103.json"}}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "S\u00f6derdahl", "given": "Gunnar", "initials": "G"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "Mielke", "given": "Stephan", "initials": "S", "orcid": "0000-0002-8325-9215", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6f17a7cc4774614a3ad5ea9c910d75a.json"}}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Bergman", "given": "Peter", "initials": "P", "orcid": "0000-0003-3306-3713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15b7290255814a7b9a1a97c3cdb2fc26.json"}}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Valentini", "given": "Davide", "initials": "D"}, {"family": "Blennow", "given": "Ola", "initials": "O", "orcid": "0000-0002-7167-7882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2318c3973e66443aa14fceca0908d127.json"}}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Gabarrini", "given": "Giorgio", "initials": "G", "orcid": "0000-0001-6936-4919", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a032980c1f294d1890979602c1a0326c.json"}}, {"family": "Al-Manei", "given": "Khaled", "initials": "K", "orcid": "0000-0003-0787-5849", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b311d335e194bba9d46406e1b73181a.json"}}, {"family": "Alkharaan", "given": "Hassan", "initials": "H"}, {"family": "Sobkowiak", "given": "Micha\u0142 Jacek", "initials": "MJ", "orcid": "0000-0003-2932-1994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f50e79d47d6845a7aeaf6deb5fe545e7.json"}}, {"family": "Yousef", "given": "Jamil", "initials": "J"}, {"family": "Mravinacova", "given": "Sara", "initials": "S"}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Xu", "given": "Xinling", "initials": "X"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K", "orcid": "0000-0001-7679-9494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02d4d3d9ccc547f7ab18ba69493f6a34.json"}}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C", "orcid": "0000-0003-0880-5375", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7394cf1c96945888fc8765568f5407c.json"}}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}, {"family": "Ljunggren", "given": "Hans Gustaf", "initials": "HG"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Aleman", "given": "Soo", "initials": "S", "orcid": "0000-0003-0461-4870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b0edb2db8d840989936f67047ce91de.json"}}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M"}], "type": "journal-article", "published": "2022-01-00", "journal": {"title": "Med (N Y)", "issn": "2666-6340", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Immunocompromised individuals are highly susceptible to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Whether vaccine-induced immunity in these individuals involves oral cavity, a primary site of infection, is presently unknown.\r\n\r\nImmunocompromised patients (n=404) and healthy controls (n=82) participated in a prospective clinical trial (NCT04780659) encompassing two doses of the mRNA BNT162b2 vaccine. Primary immunodeficiency (PID), secondary immunodeficiencies caused by human immunodeficiency virus (HIV) infection, allogeneic hematopoietic stem cell transplantation (HSCT)/chimeric antigen receptor T cell therapy (CAR-T), solid organ transplantation (SOT), and chronic lymphocytic leukemia (CLL) patients were included. Salivary and serum immunoglobulin G (IgG) reactivities to SARS-CoV-2 spike were measured by multiplex bead-based assays and Elecsys\u00ae Anti-SARS-CoV-2 S assay.\r\n\r\nIgG responses to SARS-CoV-2 spike antigens in saliva in HIV and HSCT/CAR-T groups were comparable to healthy controls after vaccination. The PID, SOT, and CLL patients had weaker responses, influenced mainly by disease parameters or immunosuppressants. Salivary responses correlated remarkably well with specific IgG titers and the neutralizing capacity in serum. Receiver operating characteristic curve analysis for the predictive power of salivary IgG yielded AUC=0.95, PPV=90.7% for entire cohort after vaccination.\r\n\r\nSaliva conveys vaccine responses induced by mRNA BNT162b2. The predictive power of salivary Spike-IgG makes it highly suitable for screening vulnerable groups for revaccination.\r\n\r\nKnut and Alice Wallenberg Foundation, Erling Perssons family foundation, Region Stockholm, Swedish Research Council, Karolinska Institutet, Swedish Blood Cancer Foundation, PID patient organization of Sweden, Nordstjernan AB, Center for Medical Innovation (CIMED), Swedish Medical Research Council, Stockholm County Council (ALF).", "doi": "10.1016/j.medj.2022.01.001", "pmid": "35075450", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null, "Research Area: Vaccine": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S2666-6340(22)00036-8"}, {"db": "pmc", "key": "PMC8770252"}], "notes": [], "created": "2022-01-26T08:15:37.719Z", "modified": "2022-02-08T19:21:59.070Z"}, {"entity": "publication", "iuid": "d14fe499bb034711ad8edfcb089c9e8f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d14fe499bb034711ad8edfcb089c9e8f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d14fe499bb034711ad8edfcb089c9e8f"}}, "title": "Robust humoral and cellular immune responses and low risk for reinfection at least 8 months following asymptomatic to mild COVID-19.", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f28f2f6ac9648629c2d2de92fe7bb59.json"}}, {"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/305bca9e5c6c423898c272bf06ce2f2a.json"}}, {"family": "Jernbom Falk", "given": "August", "initials": "A", "orcid": "0000-0002-7773-1851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40d944d7fa964f4292f10012356a2730.json"}}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N", "orcid": "0000-0003-1492-9745", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb052bdf68e4475acf519080b8ac386.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c735ef404391493980e4e51d70459ce0.json"}}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Laur\u00e9n", "given": "Ida", "initials": "I"}, {"family": "Gabrielsson", "given": "Lena", "initials": "L"}, {"family": "Salomonsson", "given": "Ann-Christin", "initials": "AC"}, {"family": "Aguilera", "given": "Katherina", "initials": "K"}, {"family": "Kihlgren", "given": "Martha", "initials": "M"}, {"family": "M\u00e5nsson", "given": "Maja", "initials": "M"}, {"family": "Rosell", "given": "Axel", "initials": "A", "orcid": "0000-0001-6280-0562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4da18c480a2d4c80ad6c7d1f97bbf917.json"}}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C", "orcid": "0000-0003-0880-5375", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7394cf1c96945888fc8765568f5407c.json"}}, {"family": "Andersson", "given": "Eni", "initials": "E"}, {"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc2c612e12284831866002f6759932d5.json"}}, {"family": "Skoglund", "given": "Lovisa", "initials": "L"}, {"family": "Yousef", "given": "Jamil", "initials": "J", "orcid": "0000-0001-5915-1258", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/324e111715fc4029badd136232057025.json"}}, {"family": "Pin", "given": "Elisa", "initials": "E", "orcid": "0000-0002-2158-2674", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5568b1a9e3c456c8ee4a95eaa55b103.json"}}, {"family": "Lord", "given": "Martin", "initials": "M", "orcid": "0000-0002-3238-3187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ddcd91137ed4f8c88b2beb2db340081.json"}}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M", "orcid": "0000-0002-7858-8233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb515ec509a94036b64bd69339bc2401.json"}}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Tegel", "given": "Hanna", "initials": "H"}, {"family": "D\u00f6nnes", "given": "Pierre", "initials": "P", "orcid": "0000-0002-4613-2952", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6924b18d27749ad99d20c69442ea52b.json"}}, {"family": "Phillipson", "given": "Mia", "initials": "M", "orcid": "0000-0002-2387-0266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/614a4a6f69204c6287a81a79a1a7a8f1.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Mangsbo", "given": "Sara", "initials": "S", "orcid": "0000-0002-1355-2678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cf494629d8a4f9584ada4be16dff66b.json"}}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1345-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a53a433db6f04a458e3d420f0c9995c5.json"}}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": "291", "issue": "1", "pages": "72-80"}, "abstract": "Emerging data support detectable immune responses for months after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination, but it is not yet established to what degree and for how long protection against reinfection lasts.\n\nWe investigated SARS-CoV-2-specific humoral and cellular immune responses more than 8 months post-asymptomatic, mild and severe infection in a cohort of 1884 healthcare workers (HCW) and 51 hospitalized COVID-19 patients. Possible protection against SARS-CoV-2 reinfection was analyzed by a weekly 3-month polymerase chain reaction (PCR) screening of 252 HCW that had seroconverted 7 months prior to start of screening and 48 HCW that had remained seronegative at multiple time points.\n\nAll COVID-19 patients and 96% (355/370) of HCW who were anti-spike IgG positive at inclusion remained anti-spike IgG positive at the 8-month follow-up. Circulating SARS-CoV-2-specific memory T cell responses were detected in 88% (45/51) of COVID-19 patients and in 63% (233/370) of seropositive HCW. The cumulative incidence of PCR-confirmed SARS-CoV-2 infection was 1% (3/252) among anti-spike IgG positive HCW (0.13 cases per 100 weeks at risk) compared to 23% (11/48) among anti-spike IgG negative HCW (2.78 cases per 100 weeks at risk), resulting in a protective effect of 95.2% (95% CI 81.9%-99.1%).\n\nThe vast majority of anti-spike IgG positive individuals remain anti-spike IgG positive for at least 8 months regardless of initial COVID-19 disease severity. The presence of anti-spike IgG antibodies is associated with a substantially reduced risk of reinfection up to 9 months following asymptomatic to mild COVID-19.", "doi": "10.1111/joim.13387", "pmid": "34459525", "labels": {"Research Area: Viral sequence evolution": null, "Research Area: Drug discovery and repurposing of drugs": null, "Category: Biochemistry": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Biobanks for COVID-19 research": null, "Research Area: Host cell systems biology and targets": null}, "xrefs": [{"db": "pmc", "key": "PMC8661920"}], "notes": [], "created": "2021-09-01T07:50:22.235Z", "modified": "2022-02-06T17:12:35.708Z"}, {"entity": "publication", "iuid": "b7c57303c3964ef7ab66ba926324329d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b7c57303c3964ef7ab66ba926324329d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b7c57303c3964ef7ab66ba926324329d"}}, "title": "Rehabilitation needs following COVID-19: Five-month post-discharge clinical follow-up of individuals with concerning self-reported symptoms.", "authors": [{"family": "Wahlgren", "given": "Carl", "initials": "C"}, {"family": "Divanoglou", "given": "Anestis", "initials": "A"}, {"family": "Larsson", "given": "Melanie", "initials": "M"}, {"family": "Nilsson", "given": "Emma", "initials": "E"}, {"family": "\u00d6stholm Balkhed", "given": "\u00c5se", "initials": "\u00c5"}, {"family": "Niward", "given": "Katarina", "initials": "K"}, {"family": "Birberg Thornberg", "given": "Ulrika", "initials": "U"}, {"family": "Lilliecreutz Gudmundsson", "given": "Eva", "initials": "E"}, {"family": "Levi", "given": "Richard", "initials": "R"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": "43", "pages": "101219", "issn-l": null}, "abstract": "This report describes and objectivizes reported problems among a cohort of previously hospitalized COVID-19 patients by clinical examination and determination of the required level of rehabilitation sevices.\n\nThis report forms part of the Link\u00f6ping COVID-19 Study (LinCoS) that included 745 individuals from one of 21 Swedish healthcare regions, Region \u00d6sterg\u00f6tland (R\u00d6), admitted to hospital for COVID-19 during March 1st-May 31st, 2020. In this descriptive ambidirectional cohort study, all 185 individuals who had reported concerning persisting symptoms were invited to a multi-professional clinical assessment of somatic, functional, affective, neuropsychological status and rehabilitation needs. Rehabilitation needs were assessed using three sub-scales of the Rehabilitation Complexity Scale-Extended.\n\nAmong the 158 (85\u00b74%) cases consenting and included in the analysis, we found a broad array of symptoms and signs attributable to COVID-19 involving respiratory, visual, auditory, motor, sensory and cognitive functions that could be confirmed clinically at five months post-discharge. This translated into 16% [95% CI 13-20] of survivors (70/433) of the total regional cohort of hospitalised patients requiring further rehabilitative interventions at follow-up. Weakness in extremities was reported in 28\u00b75% [21\u00b76, 36\u00b72] (45/158). On examination, clinically overt muscle weakness could be corroborated in 15 individuals (10\u00b75%) [6\u00b71, 16\u00b74]. 48% [40, 56] (76/158) reported cognitive symptoms, while the physician noted overt cognitive impairments in only 3% [1\u00b71, 7\u00b75]. In neuropsychological testing, 37% [28-46] (45/122) performed 1.5 SD below the norm, indicating neurocognitive deficits. Fifty-five individuals (34\u00b78%) [27\u00b74, 42\u00b78] reported new or aggravated pain. In three fourths of them, it exerted a 'moderate' or worse detrimental effect on their ability to work.\n\nOur study underscores the importance of providing extensive examination of cases with persisting problems after COVID-19, especially since symptoms such as fatigue and breathlessness are highly nonspecific, but may represent significant underlying functional impairments. Robust neurocognitive testing should be performed, as cognitive problems may easily be overlooked during routine medical consultation. In the Swedish context, most rehabilitative interventions could be provided in a primary care setting. A substantial minority of patients should be triaged to specialized rehabilitation services.", "doi": "10.1016/j.eclinm.2021.101219", "pmid": "34901798", "labels": {"Category: Rehabilitation": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(21)00500-9"}, {"db": "pmc", "key": "PMC8645256"}], "notes": [], "created": "2021-12-18T17:59:27.619Z", "modified": "2021-12-18T17:59:27.633Z"}, {"entity": "publication", "iuid": "67fddc2eeb544fe988649656d7cfb401", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/67fddc2eeb544fe988649656d7cfb401.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/67fddc2eeb544fe988649656d7cfb401"}}, "title": "Reduced risk of hospitalisation among reported COVID-19 cases infected with the SARS-CoV-2 Omicron BA.1 variant compared with the Delta variant, Norway, December 2021 to January 2022.", "authors": [{"family": "Veneti", "given": "Lamprini", "initials": "L"}, {"family": "B\u00f8\u00e5s", "given": "H\u00e5kon", "initials": "H"}, {"family": "Br\u00e5then Kristoffersen", "given": "Anja", "initials": "A"}, {"family": "St\u00e5lcrantz", "given": "Jeanette", "initials": "J"}, {"family": "Bragstad", "given": "Karoline", "initials": "K"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "Storm", "given": "Margrethe Larsdatter", "initials": "ML"}, {"family": "Aasand", "given": "Nina", "initials": "N"}, {"family": "R\u00f8", "given": "Gunnar", "initials": "G"}, {"family": "Starrfelt", "given": "Jostein", "initials": "J"}, {"family": "Sepp\u00e4l\u00e4", "given": "Elina", "initials": "E"}, {"family": "Kv\u00e5le", "given": "Reidar", "initials": "R"}, {"family": "Vold", "given": "Line", "initials": "L"}, {"family": "Nyg\u00e5rd", "given": "Karin", "initials": "K"}, {"family": "Buanes", "given": "Eirik Alnes", "initials": "EA"}, {"family": "Whittaker", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "27", "issue": "4", "issn-l": null}, "abstract": "We included 39,524 COVID-19 Omicron and 51,481 Delta cases reported in Norway from December 2021 to January 2022. We estimated a 73% reduced risk of hospitalisation (adjusted hazard ratio: 0.27; 95% confidence interval: 0.20-0.36) for Omicron compared with Delta. Compared with unvaccinated groups, Omicron cases who had completed primary two-dose vaccination 7-179 days before diagnosis had a lower reduced risk than Delta (66% vs 93%). People vaccinated with three doses had a similar risk reduction (86% vs 88%).", "doi": "10.2807/1560-7917.ES.2022.27.4.2200077", "pmid": "35086614", "labels": {"Category: Health": null, "Category: Omicron VoC": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-31T11:43:40.150Z", "modified": "2022-01-31T11:43:40.164Z"}, {"entity": "publication", "iuid": "b3e8607d21ca42449bcaf014acc8d025", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b3e8607d21ca42449bcaf014acc8d025.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b3e8607d21ca42449bcaf014acc8d025"}}, "title": "Persistent endotheliopathy in the pathogenesis of long COVID syndrome: Comment from von Meijenfeldt et al.", "authors": [{"family": "von Meijenfeldt", "given": "Fien A", "initials": "FA", "orcid": "0000-0003-0274-2414", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76b5cb67f6e243459441f06d41f0816c.json"}}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Adelmeijer", "given": "Jelle", "initials": "J"}, {"family": "Thalin", "given": "Charlotte", "initials": "C"}, {"family": "Lisman", "given": "Ton", "initials": "T", "orcid": "0000-0002-3503-7140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7431e810d13c443ca5dacbf5d368e60b.json"}}], "type": "letter", "published": "2022-01-00", "journal": {"title": "J Thromb Haemost", "issn": "1538-7836", "volume": "20", "issue": "1", "pages": "267-269", "issn-l": null}, "abstract": "To the Editor: With great interest we read the recent brief report by dr. Fogarty and colleagues providing evidence for persistent endothelial cell activation in convalescent COVID-19 patients [1]. The authors showed that plasma levels of von Willebrand factor (VWF), factor VIII, and soluble thrombomodulin were elevated at a median of 68 days after initial COVID-19 symptom resolution or discharge from the hospital. Interestingly, not all these patients experienced severe disease. Levels of endothelial injury markers were associated with long-term symptoms, including dyspnoea, fatigue and concentration impairment, often referred to as long COVID.", "doi": "10.1111/jth.15580", "pmid": "34731533", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8646477"}], "notes": [], "created": "2021-11-08T09:15:44.315Z", "modified": "2022-02-06T17:17:13.773Z"}, {"entity": "publication", "iuid": "46f10e72a5c1456791b0fcee1e08b0ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46f10e72a5c1456791b0fcee1e08b0ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46f10e72a5c1456791b0fcee1e08b0ca"}}, "title": "Modelling the direct virus exposure risk associated with respiratory events.", "authors": [{"family": "Wang", "given": "Jietuo", "initials": "J", "orcid": "0000-0002-0422-8024", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/365ae54f06934c93aff3fd56f6bb03c2.json"}}, {"family": "Dalla Barba", "given": "Federico", "initials": "F"}, {"family": "Roccon", "given": "Alessio", "initials": "A"}, {"family": "Sardina", "given": "Gaetano", "initials": "G"}, {"family": "Soldati", "given": "Alfredo", "initials": "A"}, {"family": "Picano", "given": "Francesco", "initials": "F", "orcid": "0000-0002-3943-8187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b1cf61e22c3421498d87d8df32ef247.json"}}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "J R Soc Interface", "issn": "1742-5662", "volume": "19", "issue": "186", "pages": "20210819", "issn-l": null}, "abstract": "The outbreak of the COVID-19 pandemic highlighted the importance of accurately modelling the pathogen transmission via droplets and aerosols emitted while speaking, coughing and sneezing. In this work, we present an effective model for assessing the direct contagion risk associated with these pathogen-laden droplets. In particular, using the most recent studies on multi-phase flow physics, we develop an effective yet simple framework capable of predicting the infection risk associated with different respiratory activities in different ambient conditions. We start by describing the mathematical framework and benchmarking the model predictions against well-assessed literature results. Then, we provide a systematic assessment of the effects of physical distancing and face coverings on the direct infection risk. The present results indicate that the risk of infection is vastly impacted by the ambient conditions and the type of respiratory activity, suggesting the non-existence of a universal safe distance. Meanwhile, wearing face masks provides excellent protection, effectively limiting the transmission of pathogens even at short physical distances, i.e. 1 m.", "doi": "10.1098/rsif.2021.0819", "pmid": "35016556", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Funder: VR": null}, "xrefs": [{"db": "URL", "key": "http://dx.doi.org/10.6084/m9.figshare.16826374", "description": "http://dx.doi.org/10.6084/m9.figshare.16826374"}], "notes": [], "created": "2022-01-13T21:01:11.242Z", "modified": "2022-01-13T21:03:34.222Z"}, {"entity": "publication", "iuid": "dee615b15b7b408c8ccef80f93daeed6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dee615b15b7b408c8ccef80f93daeed6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dee615b15b7b408c8ccef80f93daeed6"}}, "title": "Initial impacts of the COVID-19 pandemic on sexual and reproductive health service use and unmet need in Britain: findings from a quasi-representative survey (Natsal-COVID).", "authors": [{"family": "Dema", "given": "Emily", "initials": "E"}, {"family": "Gibbs", "given": "Jo", "initials": "J"}, {"family": "Clifton", "given": "Soazig", "initials": "S"}, {"family": "Copas", "given": "Andrew J", "initials": "AJ"}, {"family": "Tanton", "given": "Clare", "initials": "C"}, {"family": "Riddell", "given": "Julie", "initials": "J"}, {"family": "P\u00e9rez", "given": "Raquel Bos\u00f3", "initials": "RB"}, {"family": "Reid", "given": "David", "initials": "D"}, {"family": "Bonell", "given": "Chris", "initials": "C"}, {"family": "Unemo", "given": "Magnus", "initials": "M"}, {"family": "Mercer", "given": "Catherine H", "initials": "CH"}, {"family": "Mitchell", "given": "Kirstin R", "initials": "KR"}, {"family": "Sonnenberg", "given": "Pam", "initials": "P"}, {"family": "Field", "given": "Nigel", "initials": "N"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "Lancet Public Health", "issn": "2468-2667", "volume": "7", "issue": "1", "pages": "e36-e47", "issn-l": null}, "abstract": "The COVID-19 pandemic has affected sexual and reproductive health (SRH) service use and unmet need, but the impact is unknown. We aimed to determine the proportion of participants reporting sexual risk behaviours, SRH service use and unmet need, and to assess remote sexually transmitted infection (STI) testing service use after the first national lockdown in Britain.\n\nWe used data from the National Surveys of Sexual Attitudes and Lifestyles (Natsal)-COVID cross-sectional, quasi-representative web survey (Natsal-COVID Wave 1). Adults aged 18-59 years who resided in England, Scotland, or Wales completed the survey between July 29 and Aug 10, 2020, which included questions about the approximate 4-month period after announcement of the initial lockdown in Britain (March 23, 2020). Quota-based sampling and weighting were used to achieve a quasi-representative population sample. Participants aged 45-59 years were excluded from services analysis due to low rates of SRH service use. Among individuals aged 18-44 years, we estimated reported SRH service use and inability to access, and calculated age-adjusted odds ratios (aORs) among sexually experienced individuals (those reporting any sexual partner in their lifetime) and sexually active individuals (those reporting any sexual partner in the past year). Unweighted denominators and weighted estimates are presented hereafter.\n\n6654 individuals had complete interviews and were included in the analysis. Among 3758 participants aged 18-44 years, 82\u00b70% reported being sexually experienced, and 73\u00b77% reported being sexually active. 20\u00b78% of sexually experienced participants aged 18-44 years reported using SRH services in the 4-month period. Overall, 9\u00b77% of 3108 participants (9\u00b75% of men; 9\u00b79% of women) reported being unable to use a service they needed, although of the participants who reported trying but not being able to use a SRH service at least once, 76\u00b74% of participants also reported an instance of successful use. 5\u00b79% of 1221 sexually active men and 3\u00b76% of 1560 sexually active women reported use of STI-related services and 14\u00b78% of 1728 sexually experienced women reported use of contraceptive services, with SRH service use highest among individuals aged 18-24 years. Sexually active participants reporting condomless sex with new partners since lockdown were much more likely to report using STI-related services than those who did not report condomless sex (aOR 23\u00b78 [95% CI 11\u00b76-48\u00b79]) for men, 10\u00b75 [3\u00b79-28\u00b72] for women) and, among men, were also more likely to have an unsuccessful attempt at STI-service use (aOR 13\u00b73 [5\u00b73-32\u00b79]). Among 106 individuals who reported using STI testing services, 64\u00b74% accessed services remotely (telephone, video, or online). Among 2581 women aged 25-59 years, 2\u00b74% reported cervical screening compared with an estimated 6% in a comparable 4-month period before the pandemic.\n\nMany people accessed SRH care during the initial lockdown; however, young people and those reporting sexual risk behaviours reported difficulties in accessing services and thus such services might need to address a backlog of need.\n\nWellcome Trust, The Economic and Social Research Council, The National Institute for Health Research, Medical Research Council/Chief Scientist Office and Public Health Sciences Unit, and UCL Coronavirus Response Fund.", "doi": "10.1016/S2468-2667(21)00253-X", "pmid": "34995541", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2468-2667(21)00253-X"}], "notes": [], "created": "2022-01-10T15:31:13.250Z", "modified": "2022-01-10T15:31:13.264Z"}, {"entity": "publication", "iuid": "99ed1321db26492d99260e63ebb3cb29", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/99ed1321db26492d99260e63ebb3cb29.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/99ed1321db26492d99260e63ebb3cb29"}}, "title": "Global Behaviors, Perceptions, and the Emergence of Social Norms at the Onset of the COVID-19 Pandemic.", "authors": [{"family": "Hensel", "given": "Lukas", "initials": "L"}, {"family": "Witte", "given": "Marc", "initials": "M"}, {"family": "Caria", "given": "A Stefano", "initials": "AS"}, {"family": "Fetzer", "given": "Thiemo", "initials": "T"}, {"family": "Fiorin", "given": "Stefano", "initials": "S"}, {"family": "G\u00f6tz", "given": "Friedrich M", "initials": "FM"}, {"family": "Gomez", "given": "Margarita", "initials": "M"}, {"family": "Haushofer", "given": "Johannes", "initials": "J"}, {"family": "Ivchenko", "given": "Andriy", "initials": "A"}, {"family": "Kraft-Todd", "given": "Gordon", "initials": "G"}, {"family": "Reutskaja", "given": "Elena", "initials": "E"}, {"family": "Roth", "given": "Christopher", "initials": "C"}, {"family": "Yoeli", "given": "Erez", "initials": "E"}, {"family": "Jachimowicz", "given": "Jon M", "initials": "JM"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "J Econ Behav Organ", "issn": "0167-2681", "issn-l": null, "volume": "193u", "issue": null, "pages": "473-496"}, "abstract": "We conducted a large-scale survey covering 58 countries and over 100,000 respondents between late March and early April 2020 to study beliefs and attitudes towards citizens' and governments' responses at the onset of the COVID-19 pandemic. Most respondents reported holding normative beliefs in support of COVID-19 containment measures, as well as high rates of adherence to these measures. They also believed that their government and their country's citizens were not doing enough and underestimated the degree to which others in their country supported strong behavioral and policy responses to the pandemic. Normative beliefs were strongly associated with adherence, as well as beliefs about others' and the government's response. Lockdowns were associated with greater optimism about others' and the government's response, and improvements in measures of perceived mental well-being; these effects tended to be larger for those with stronger normative beliefs. Our findings highlight how social norms can arise quickly and effectively to support cooperation at a global scale.", "doi": "10.1016/j.jebo.2021.11.015", "pmid": "34955573", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0167-2681(21)00487-X"}, {"db": "pmc", "key": "PMC8684329"}], "notes": [], "created": "2022-01-04T15:24:43.619Z", "modified": "2022-11-22T05:42:28.273Z"}, {"entity": "publication", "iuid": "7468bf355bed49c5a260c0c5f2d0b6eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7468bf355bed49c5a260c0c5f2d0b6eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7468bf355bed49c5a260c0c5f2d0b6eb"}}, "title": "Correction: Effects of the COVID-19 pandemic on patients with inflammatory joint diseases in Sweden: from infection severity to impact on care provision.", "authors": [], "type": "journal article", "published": "2022-01-00", "journal": {"title": "RMD Open", "issn": "2056-5933", "volume": "8", "issue": "1", "issn-l": null}, "abstract": null, "doi": "10.1136/rmdopen-2021-001987corr1", "pmid": "35042729", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "rmdopen-2021-001987corr1"}, {"db": "pmc", "key": "PMC8783965"}], "notes": [], "created": "2022-01-27T07:07:25.027Z", "modified": "2022-01-27T07:07:25.042Z"}, {"entity": "publication", "iuid": "7a040f43e3654844a378be43affb954b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a040f43e3654844a378be43affb954b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a040f43e3654844a378be43affb954b"}}, "title": "Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.", "authors": [{"family": "Fallerini", "given": "Chiara", "initials": "C"}, {"family": "Picchiotti", "given": "Nicola", "initials": "N"}, {"family": "Baldassarri", "given": "Margherita", "initials": "M"}, {"family": "Zguro", "given": "Kristina", "initials": "K"}, {"family": "Daga", "given": "Sergio", "initials": "S"}, {"family": "Fava", "given": "Francesca", "initials": "F"}, {"family": "Benetti", "given": "Elisa", "initials": "E"}, {"family": "Amitrano", "given": "Sara", "initials": "S"}, {"family": "Bruttini", "given": "Mirella", "initials": "M"}, {"family": "Palmieri", "given": "Maria", "initials": "M"}, {"family": "Croci", "given": "Susanna", "initials": "S"}, {"family": "Lista", "given": "Mirjam", "initials": "M"}, {"family": "Beligni", "given": "Giada", "initials": "G"}, {"family": "Valentino", "given": "Floriana", "initials": "F"}, {"family": "Meloni", "given": "Ilaria", "initials": "I"}, {"family": "Tanfoni", "given": "Marco", "initials": "M"}, {"family": "Minnai", "given": "Francesca", "initials": "F"}, {"family": "Colombo", "given": "Francesca", "initials": "F"}, {"family": "Cabri", "given": "Enrico", "initials": "E"}, {"family": "Fratelli", "given": "Maddalena", "initials": "M"}, {"family": "Gabbi", "given": "Chiara", "initials": "C"}, {"family": "Mantovani", "given": "Stefania", "initials": "S"}, {"family": "Frullanti", "given": "Elisa", "initials": "E"}, {"family": "Gori", "given": "Marco", "initials": "M"}, {"family": "Crawley", "given": "Francis P", "initials": "FP"}, {"family": "Butler-Laporte", "given": "Guillaume", "initials": "G"}, {"family": "Richards", "given": "Brent", "initials": "B"}, {"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Ludwig", "given": "Kerstin U", "initials": "KU"}, {"family": "Schulte", "given": "Eva C", "initials": "EC"}, {"family": "Pairo-Castineira", "given": "Erola", "initials": "E"}, {"family": "Baillie", "given": "John Kenneth", "initials": "JK"}, {"family": "Schmidt", "given": "Axel", "initials": "A"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "WES/WGS Working Group Within the HGI", "given": "", "initials": ""}, {"family": "GenOMICC Consortium", "given": "", "initials": ""}, {"family": "GEN-COVID Multicenter Study", "given": "", "initials": ""}, {"family": "Mari", "given": "Francesca", "initials": "F"}, {"family": "Renieri", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-0846-9220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6388ba45f89d4c3b94c4c6c88f97cadb.json"}}, {"family": "Furini", "given": "Simone", "initials": "S"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "Hum Genet", "issn": "0340-6717", "issn-l": null, "volume": "141", "issue": "1", "pages": "147-173"}, "abstract": "The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management.", "doi": "10.1007/s00439-021-02397-7", "pmid": "34889978", "labels": {"Type: Journal article": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pmc", "key": "PMC8661833"}, {"db": "pii", "key": "10.1007/s00439-021-02397-7"}], "notes": [], "created": "2021-12-12T06:48:31.290Z", "modified": "2023-07-13T11:31:18.816Z"}, {"entity": "publication", "iuid": "bd9e593ee2964a518247d66165ff1c1e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bd9e593ee2964a518247d66165ff1c1e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bd9e593ee2964a518247d66165ff1c1e"}}, "title": "Associations of pre-pandemic levels of physical function and physical activity with COVID-19-like symptoms during the outbreak.", "authors": [{"family": "Saadeh", "given": "Marguerita", "initials": "M", "orcid": "0000-0002-2689-5784", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/324dbc9ae7ec4e5daab17e7fab6a183c.json"}}, {"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A"}, {"family": "Vetrano", "given": "Davide Liborio", "initials": "DL"}, {"family": "von Rosen", "given": "Philip", "initials": "P"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Welmer", "given": "Anna-Karin", "initials": "AK"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "Aging Clin Exp Res", "issn": "1720-8319", "volume": "34", "issue": "1", "pages": "235-247", "issn-l": "1594-0667"}, "abstract": "One's physical function and physical activity levels can predispose or protect from the development of respiratory infections. We aimed to explore the associations between pre-pandemic levels of physical function and physical activity and the development of COVID-19-like symptoms in Swedish older adults.\n\nWe analyzed data from 904 individuals aged \u2265 68 years from the population-based Swedish National study on Aging and Care in Kungsholmen. COVID-19-like symptoms were assessed by phone interview (March-June 2020) and included fever, cough, sore throat and/or a cold, headache, pain in muscles, legs and joints, loss of taste and/or odor, breathing difficulties, chest pain, gastrointestinal symptoms, and eye inflammation. Muscle strength, mobility, and physical activity were examined in 2016-2018 by objective testing. Data were analyzed using logistic regression models in the total sample and stratifying by age.\n\nDuring the first outbreak of the pandemic, 325 (36%) individuals from our sample developed COVID-19-like symptoms. Those with slower performance in the chair stand test had an odds ratio (OR) of 1.5 (95% confidence interval [CI] 1.1-2.1) for presenting with COVID-19-like symptoms compared to better performers, after adjusting for potential confounders. The association was even higher among people aged \u2265 80 years (OR 2.6; 95% CI 1.5-4.7). No significant associations were found between walking speed or engagement in moderate-to-vigorous physical activity and the likelihood to develop COVID-19-like symptoms.\n\nPoor muscle strength, a possible indicator of frailty, may predispose older adults to higher odds of developing COVID-19-like symptoms, especially among the oldest-old.", "doi": "10.1007/s40520-021-02006-7", "pmid": "34716912", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8556821"}, {"db": "pii", "key": "10.1007/s40520-021-02006-7"}], "notes": [], "created": "2021-11-01T19:52:53.543Z", "modified": "2023-06-19T15:29:59.121Z"}, {"entity": "publication", "iuid": "4d20e161965b43b89cd46cf341eab89c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4d20e161965b43b89cd46cf341eab89c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4d20e161965b43b89cd46cf341eab89c"}}, "title": "Association between first language and SARS-CoV-2 infection rates, hospitalization, intensive care admissions and death in Finland: a population-based observational cohort study.", "authors": [{"family": "Holmberg", "given": "Ville", "initials": "V"}, {"family": "Salmi", "given": "Heli", "initials": "H"}, {"family": "Kattainen", "given": "Salla", "initials": "S"}, {"family": "Ollgren", "given": "Jukka", "initials": "J"}, {"family": "Kantele", "given": "Anu", "initials": "A"}, {"family": "Pynn\u00f6nen", "given": "Juulia", "initials": "J"}, {"family": "J\u00e4rvinen", "given": "Asko", "initials": "A"}, {"family": "Forsblom", "given": "Erik", "initials": "E"}, {"family": "Sil\u00e9n", "given": "Suvi", "initials": "S"}, {"family": "Kivivuori", "given": "Sanna-Maria", "initials": "SM"}, {"family": "Meretoja", "given": "Atte", "initials": "A"}, {"family": "H\u00e4stbacka", "given": "Johanna", "initials": "J"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "Clin Microbiol Infect", "issn": "1469-0691", "volume": "28", "issue": "1", "pages": "107-113", "issn-l": null}, "abstract": "Motivated by reports of increased risk of coronavirus disease 2019 (COVID-19) in ethnic minorities of high-income countries, we explored whether patients with a foreign first language are at an increased risk of COVID-19 infections, more serious presentations, or worse outcomes.\n\nIn a retrospective observational population-based quality registry study covering a population of 1.7 million, we studied the incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), admissions to specialist healthcare and the intensive care unit (ICU), and all-cause case fatality in different language groups between 27th February and 3rd August 2020 in Southern Finland. A first language other than Finnish, Swedish or S\u00e1mi served as a surrogate marker for a foreign ethnic background.\n\nIn total, 124 240 individuals were tested, and among the 118 300 (95%) whose first language could be determined, 4005 (3.4%) were COVID-19-positive, 623 (0.5%) were admitted to specialized hospitals, and 147 (0.1%) were admitted to the ICU; 254 (0.2%) died. Those with a foreign first language had lower testing rates (348, 95%CI 340-355 versus 758, 95%CI 753-762 per 10 000, p < 0.0001), higher incidence (36, 95%CI 33-38 versus 22, 95%CI 21-23 per 10 000, p < 0.0001), and higher positivity rates (103, 95%CI 96-109 versus 29, 95%CI 28-30 per 1000, p < 0.0001). There was no significant difference in ICU admissions, disease severity at ICU admission, or ICU outcomes. Case fatality by 90 days was 7.7% in domestic cases and 1.2% in those with a foreign first language, explained by demographics (age- and sex-adjusted HR 0.49, 95%CI 0.21-1.15).\n\nThe population with a foreign first language was at an increased risk for testing positive for SARS-CoV-2, but when hospitalized they had outcomes similar to those in the native, domestic language population. This suggests that special attention should be paid to the prevention and control of infectious diseases among language minorities.", "doi": "10.1016/j.cmi.2021.08.022", "pmid": "34949510", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(21)00484-5"}, {"db": "pmc", "key": "PMC8482016"}], "notes": [], "created": "2022-01-04T15:29:14.195Z", "modified": "2022-01-04T15:29:14.219Z"}, {"entity": "publication", "iuid": "a2842bb0d7a54c41838a25b1708d64d2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2842bb0d7a54c41838a25b1708d64d2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2842bb0d7a54c41838a25b1708d64d2"}}, "title": "Characterizing Post-COVID Syndrome in Outpatient and Inpatient Setting in Sweden Using Diagnosis Codes - A Nationwide Observational Cohort and Matched Cohort Study", "authors": [{"family": "Ollila", "given": "Hanna M", "initials": "HM"}, {"family": "Fonseca", "given": "Osvaldo", "initials": "O"}, {"family": "Caspersen", "given": "Ida Henriette", "initials": "IH"}, {"family": "Kalucza", "given": "Sebastian", "initials": "S"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Trogstad", "given": "Lill", "initials": "L"}, {"family": "Magnus", "given": "Per", "initials": "P"}, {"family": "Hulvej Rod", "given": "Naja", "initials": "N"}, {"family": "Ganna", "given": "Andrea", "initials": "A"}, {"family": "Eriksson", "given": "Marie", "initials": "M"}, {"family": "Fors Connolly", "given": "Anne Marie", "initials": "AM"}], "type": "journal-article", "published": "2022-00-00", "journal": {"title": "SSRN Journal", "issn": "1556-5068", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.2139/ssrn.4276607", "pmid": null, "labels": {"Research Area: Vaccine": null, "Type: Preprint": null, "Category: Health": null, "Topics: Register-based research": null, "Category: Post-COVID": null}, "xrefs": [], "notes": [], "created": "2022-11-29T08:49:10.019Z", "modified": "2022-11-29T09:29:28.220Z"}, {"entity": "publication", "iuid": "5d991aa79d974f8fad60017f9324ba52", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d991aa79d974f8fad60017f9324ba52.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d991aa79d974f8fad60017f9324ba52"}}, "title": "Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges.", "authors": [{"family": "Masterson", "given": "C H", "initials": "CH"}, {"family": "Ceccato", "given": "A", "initials": "A"}, {"family": "Artigas", "given": "A", "initials": "A"}, {"family": "Dos Santos", "given": "C", "initials": "C"}, {"family": "Rocco", "given": "P R", "initials": "PR"}, {"family": "Rolandsson Enes", "given": "S", "initials": "S"}, {"family": "Weiss", "given": "D J", "initials": "DJ"}, {"family": "McAuley", "given": "D", "initials": "D"}, {"family": "Matthay", "given": "M A", "initials": "MA"}, {"family": "English", "given": "K", "initials": "K"}, {"family": "Curley", "given": "G F", "initials": "GF"}, {"family": "Laffey", "given": "J G", "initials": "JG", "orcid": "0000-0002-1246-9573", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9ea7776786048ec82a309a61925d42d.json"}}], "type": "journal article", "published": "2021-12-31", "journal": {"title": "Intensive Care Med Exp", "issn": "2197-425X", "volume": "9", "issue": "1", "pages": "61", "issn-l": null}, "abstract": "Severe viral pneumonia is a significant cause of morbidity and mortality globally, whether due to outbreaks of endemic viruses, periodic viral epidemics, or the rarer but devastating global viral pandemics. While limited anti-viral therapies exist, there is a paucity of direct therapies to directly attenuate viral pneumonia-induced lung injury, and management therefore remains largely supportive. Mesenchymal stromal/stem cells (MSCs) are receiving considerable attention as a cytotherapeutic for viral pneumonia. Several properties of MSCs position them as a promising therapeutic strategy for viral pneumonia-induced lung injury as demonstrated in pre-clinical studies in relevant models. More recently, early phase clinical studies have demonstrated a reassuring safety profile of these cells. These investigations have taken on an added importance and urgency during the COVID-19 pandemic, with multiple trials in progress across the globe. In parallel with clinical translation, strategies are being investigated to enhance the therapeutic potential of these cells in vivo, with different MSC tissue sources, specific cellular products including cell-free options, and strategies to 'licence' or 'pre-activate' these cells, all being explored. This review will assess the therapeutic potential of MSC-based therapies for severe viral pneumonia. It will describe the aetiology and epidemiology of severe viral pneumonia, describe current therapeutic approaches, and examine the data suggesting therapeutic potential of MSCs for severe viral pneumonia in pre-clinical and clinical studies. The challenges and opportunities for MSC-based therapies will then be considered.", "doi": "10.1186/s40635-021-00424-5", "pmid": "34970706", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s40635-021-00424-5"}], "notes": [], "created": "2022-01-04T14:58:20.132Z", "modified": "2022-01-04T14:58:20.209Z"}, {"entity": "publication", "iuid": "2f28263688924fa99d560148ba0d0bec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2f28263688924fa99d560148ba0d0bec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2f28263688924fa99d560148ba0d0bec"}}, "title": "Identifying Risk of Adverse Outcomes in COVID-19 Patients via Artificial Intelligence-Powered Analysis of 12-Lead Intake Electrocardiogram.", "authors": [{"family": "Sridhar", "given": "Arun R", "initials": "AR"}, {"family": "Chen", "given": "Zih-Hua", "initials": "ZH"}, {"family": "Mayfield", "given": "Jacob J", "initials": "JJ"}, {"family": "Fohner", "given": "Alison E", "initials": "AE"}, {"family": "Arvanitis", "given": "Panagiotis", "initials": "P"}, {"family": "Atkinson", "given": "Sarah", "initials": "S"}, {"family": "Braunschweig", "given": "Frieder", "initials": "F"}, {"family": "Chatterjee", "given": "Neal A", "initials": "NA"}, {"family": "Zamponi", "given": "Alessio Falasca", "initials": "AF"}, {"family": "Johnson", "given": "Gregory", "initials": "G"}, {"family": "Joshi", "given": "Sanika A", "initials": "SA"}, {"family": "Lassen", "given": "Mats C H", "initials": "MCH"}, {"family": "Poole", "given": "Jeanne E", "initials": "JE"}, {"family": "Rumer", "given": "Christopher", "initials": "C"}, {"family": "Skaarup", "given": "Kristoffer G", "initials": "KG"}, {"family": "Biering-S\u00f8rensen", "given": "Tor", "initials": "T"}, {"family": "Blomstrom-Lundqvist", "given": "Carina", "initials": "C"}, {"family": "Linde", "given": "Cecilia M", "initials": "CM"}, {"family": "Maleckar", "given": "Mary M", "initials": "MM"}, {"family": "Boyle", "given": "Patrick M", "initials": "PM"}], "type": "journal article", "published": "2021-12-31", "journal": {"title": "Cardiovasc Digit Health J", "issn": "2666-6936", "issn-l": null}, "abstract": "Adverse events in COVID-19 are difficult to predict. Risk stratification is encumbered by the need to protect healthcare workers. We hypothesize that AI can help identify subtle signs of myocardial involvement in the 12-lead electrocardiogram (ECG), which could help predict complications.\n\nUse intake ECGs from COVID-19 patients to train AI models to predict risk of mortality or major adverse cardiovascular events (MACE).\n\nWe studied intake ECGs from 1448 COVID-19 patients (60.5% male, 63.4\u00b116.9 years). Records were labeled by mortality (death vs. discharge) or MACE (no events vs. arrhythmic, heart failure [HF], or thromboembolic [TE] events), then used to train AI models; these were compared to conventional regression models developed using demographic and comorbidity data.\n\n245 (17.7%) patients died (67.3% male, 74.5\u00b114.4 years); 352 (24.4%) experienced at least one MACE (119 arrhythmic; 107 HF; 130 TE). AI models predicted mortality and MACE with area under the curve (AUC) values of 0.60\u00b10.05 and 0.55\u00b10.07, respectively; these were comparable to AUC values for conventional models (0.73\u00b10.07 and 0.65\u00b10.10). There were no prominent temporal trends in mortality rate or MACE incidence in our cohort; holdout testing with data from after a cutoff date (June 9, 2020) did not degrade model performance.\n\nUsing intake ECGs alone, our AI models had limited ability to predict hospitalized COVID-19 patients' risk of mortality or MACE. Our models' accuracy was comparable to that of conventional models built using more in-depth information, but translation to clinical use would require higher sensitivity and positive predictive value. In the future, we hope that mixed-input AI models utilizing both ECG and clinical data may be developed to enhance predictive accuracy.", "doi": "10.1016/j.cvdhj.2021.12.003", "pmid": "35005676", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2666-6936(21)00146-8"}, {"db": "pmc", "key": "PMC8719367"}], "notes": [], "created": "2022-01-13T21:10:16.886Z", "modified": "2022-01-13T21:10:16.926Z"}, {"entity": "publication", "iuid": "0d6ab44032aa4e2780a6e8133916cf4e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d6ab44032aa4e2780a6e8133916cf4e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d6ab44032aa4e2780a6e8133916cf4e"}}, "title": "Baseline knowledge and attitudes on COVID-19 among hotels' staff: A cross-sectional study in Kigali, Rwanda.", "authors": [{"family": "Hagabimana", "given": "Aphrodis", "initials": "A", "orcid": "0000-0003-3658-4020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a791da28dc4401180cf45fe59ed2b8b.json"}}, {"family": "Omolo", "given": "Jared", "initials": "J"}, {"family": "El-Khatib", "given": "Ziad", "initials": "Z"}, {"family": "Rwagasore", "given": "Edson", "initials": "E"}, {"family": "Benemariya", "given": "Noella", "initials": "N"}, {"family": "Nsekuye", "given": "Olivier", "initials": "O"}, {"family": "Kabeja", "given": "Adeline", "initials": "A"}, {"family": "Balisanga", "given": "Helene", "initials": "H"}, {"family": "Umutoni", "given": "Angela", "initials": "A"}, {"family": "Musafili", "given": "Aimable", "initials": "A"}, {"family": "Ndagijimana", "given": "Albert", "initials": "A"}], "type": "journal article", "published": "2021-12-31", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "12", "pages": "e0261744", "issn-l": "1932-6203"}, "abstract": "The World Health Organization declared coronavirus disease 2019 (COVID-19) as a global pandemic on the 11th of March, 2020. Hotels and other public establishments have been associated with higher transmission rates. Sensitisation of staff and strengthening of Infection Prevention and Control (IPC) practices in such settings are important interventions. This study assessed the baseline knowledge and attitudes on COVID-19 among hotels' representatives in Kigali, Rwanda.\n\nA cross-sectional study was conducted among hotels' staff in Kigali in July 2020. A structured questionnaire was self-administered to 104 participants. Baseline knowledge and attitudes were assessed using a number of pre-test questions and mean scores were used to dichotomise the participants' responses as satisfactory or unsatisfactory.\n\nAll of the 104 hotels' staff completed the self-administered questionnaires. Sixty-seven percent (n = 70) were male and 58% (n = 60) were aged between 30 and 44 years. The satisfactory rate of correct answers was 63%\u00b12.4 (n = 66) on knowledge and 68%\u00b11.7 (n = 71) on attitudes evaluation. Participants with University education were more likely to have satisfactory knowledge (AOR: 2.6, 95% C.I: 1.07-6.58) than those with secondary education or less. The staff working in the front-office (AOR: 0.05; 95% CI 0.01-0.54) and housekeeping (AOR: 0.09; 95% C.I: 0.01-0.87) were less likely to have satisfactory attitudes than those working in the administration.\n\nHotels' staff based in the capital of Rwanda have shown satisfactory knowledge and attitudes regarding appropriate IPC practices for preventing the COVID-19 transmission. Educational interventions are needed to improve their knowledge and attitudes for better prevention in this setting.", "doi": "10.1371/journal.pone.0261744", "pmid": "34972131", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-30529"}], "notes": [], "created": "2022-01-04T14:57:44.192Z", "modified": "2022-01-04T14:57:44.255Z"}, {"entity": "publication", "iuid": "2249183c14434629ab13489a5ec18ac4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2249183c14434629ab13489a5ec18ac4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2249183c14434629ab13489a5ec18ac4"}}, "title": "A cohort study of the effect of SARS-CoV-2 point of care rapid RT-PCR at the Emergency Department on targeted admission", "authors": [{"family": "Mortazavi", "given": "Susanne E", "initials": "SE"}, {"family": "Inghammar", "given": "Malin", "initials": "M"}, {"family": "Christiansen", "given": "Claus", "initials": "C"}, {"family": "Pesola", "given": "Anne Katrine", "initials": "AK"}, {"family": "Stenkilsson", "given": "Mikael", "initials": "M"}, {"family": "Paulsson", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1104-2727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0e37d2d03f64fe78a0e84f53922d29f.json"}}], "type": "posted-content", "published": "2021-12-31", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.12.29.21268501", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:42:04.720Z", "modified": "2022-01-04T15:42:04.767Z"}, {"entity": "publication", "iuid": "e4ca08d68b2545e686009a01d2c3b963", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e4ca08d68b2545e686009a01d2c3b963.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e4ca08d68b2545e686009a01d2c3b963"}}, "title": "Toothbrush as a sampling methodology for detection of SARS- CoV-2.", "authors": [{"family": "Gupta", "given": "Shipra", "initials": "S", "orcid": "0000-0003-2097-2459", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa6dd4cea3824827b3ead550b8267b2a.json"}}, {"family": "Mohindra", "given": "Ritin", "initials": "R"}, {"family": "Jain", "given": "Akanksha", "initials": "A"}, {"family": "Singla", "given": "Mohita", "initials": "M"}, {"family": "Sorsa", "given": "Timo", "initials": "T"}, {"family": "R\u00e4is\u00e4nen", "given": "Ismo", "initials": "I", "orcid": "0000-0001-5821-5299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5688183e182e4194888dc98301077bab.json"}}, {"family": "Malhotra", "given": "Meenakshi", "initials": "M"}, {"family": "Soni", "given": "Roop Kishor", "initials": "RK"}, {"family": "Kumar", "given": "Amit", "initials": "A"}, {"family": "Kanta", "given": "Poonam", "initials": "P"}, {"family": "Gauba", "given": "Krishan", "initials": "K"}, {"family": "Singh", "given": "Mini P", "initials": "MP"}, {"family": "Ghosh", "given": "Arnab", "initials": "A"}, {"family": "Suri", "given": "Vikas", "initials": "V"}], "type": "letter", "published": "2021-12-30", "journal": {"title": "Oral Dis", "issn": "1601-0825", "issn-l": null}, "abstract": null, "doi": "10.1111/odi.14122", "pmid": "34967494", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T14:59:04.321Z", "modified": "2022-01-04T14:59:04.366Z"}, {"entity": "publication", "iuid": "c68e747b1b914f13a00ff1399358cd10", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c68e747b1b914f13a00ff1399358cd10.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c68e747b1b914f13a00ff1399358cd10"}}, "title": "Experiences of Stress - A Focus Group Interview Study Among Swedish Adolescents During the COVID-19 Pandemic.", "authors": [{"family": "H\u00f6rbo", "given": "Moa", "initials": "M"}, {"family": "Johansson", "given": "Camilla", "initials": "C"}, {"family": "Garnow", "given": "Tide", "initials": "T"}, {"family": "Garmy", "given": "Pernilla", "initials": "P", "orcid": "0000-0003-1643-0171", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc4733a9e87a42fea6e7a7323feb61b3.json"}}, {"family": "Einberg", "given": "Eva-Lena", "initials": "EL", "orcid": "0000-0002-5586-3810", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d67e636861d492fb682ec1601422cd0.json"}}], "type": "journal article", "published": "2021-12-30", "journal": {"title": "J Sch Nurs", "issn": "1546-8364", "pages": "10598405211071002", "issn-l": null}, "abstract": "Adolescence can be a stressful period in life. The period contains challenges associated with the transition from childhood to adulthood (body changes, changes in interpersonal relationships, and identity changes). The aim was to investigate experiences of stress among adolescents in addition to stress related to the COVID-19 pandemic. Focus group interviews (n = 8) were conducted with girls (n = 22) and boys (n = 19) aged 13-15 in southern Sweden. The transcribed interviews were analyzed with qualitative content analysis. Analysis of the collected material resulted in two categories with four sub-categories each of which highlights adolescents' experiences of stress. The results show that adolescents' have a variety of experiences of stress, i.e., what they mean are the sources of stress and how stress is manifested. The adolescents experienced how stress was manifested both physically and emotionally. This affected both their sleep and performance. The adolescents reflected on both positive and negative manifestations of stress.", "doi": "10.1177/10598405211071002", "pmid": "34967254", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T14:59:47.820Z", "modified": "2022-01-04T14:59:47.935Z"}, {"entity": "publication", "iuid": "cd00b8efc485401f883f70b7c92aeb11", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd00b8efc485401f883f70b7c92aeb11.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd00b8efc485401f883f70b7c92aeb11"}}, "title": "The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males.", "authors": [{"family": "Croci", "given": "Susanna", "initials": "S"}, {"family": "Venneri", "given": "Mary Anna", "initials": "MA"}, {"family": "Mantovani", "given": "Stefania", "initials": "S"}, {"family": "Fallerini", "given": "Chiara", "initials": "C"}, {"family": "Benetti", "given": "Elisa", "initials": "E"}, {"family": "Picchiotti", "given": "Nicola", "initials": "N"}, {"family": "Campolo", "given": "Federica", "initials": "F"}, {"family": "Imperatore", "given": "Francesco", "initials": "F"}, {"family": "Palmieri", "given": "Maria", "initials": "M"}, {"family": "Daga", "given": "Sergio", "initials": "S"}, {"family": "Gabbi", "given": "Chiara", "initials": "C"}, {"family": "Montagnani", "given": "Francesca", "initials": "F"}, {"family": "Beligni", "given": "Giada", "initials": "G"}, {"family": "Farias", "given": "Ticiana D J", "initials": "TDJ"}, {"family": "Carriero", "given": "Miriam Lucia", "initials": "ML"}, {"family": "Di Sarno", "given": "Laura", "initials": "L"}, {"family": "Alaverdian", "given": "Diana", "initials": "D"}, {"family": "Aslaksen", "given": "Sigrid", "initials": "S"}, {"family": "Cubellis", "given": "Maria Vittoria", "initials": "MV"}, {"family": "Spiga", "given": "Ottavia", "initials": "O", "orcid": "0000-0002-0263-7107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc173dee23db417c8875e9c9c8f9125b.json"}}, {"family": "Baldassarri", "given": "Margherita", "initials": "M"}, {"family": "Fava", "given": "Francesca", "initials": "F"}, {"family": "Norman", "given": "Paul J", "initials": "PJ"}, {"family": "Frullanti", "given": "Elisa", "initials": "E"}, {"family": "Isidori", "given": "Andrea M", "initials": "AM", "orcid": "0000-0002-9037-5417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d1bed69cf714996b0a64db788a882f5.json"}}, {"family": "Amoroso", "given": "Antonio", "initials": "A"}, {"family": "Mari", "given": "Francesca", "initials": "F"}, {"family": "Furini", "given": "Simone", "initials": "S"}, {"family": "Mondelli", "given": "Mario U", "initials": "MU"}, {"family": "Chiariello", "given": "Mario", "initials": "M"}, {"family": "Renieri", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-0846-9220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6388ba45f89d4c3b94c4c6c88f97cadb.json"}}, {"family": "Meloni", "given": "Ilaria", "initials": "I"}], "type": "journal article", "published": "2021-12-29", "journal": {"title": "Autophagy", "issn": "1554-8635", "pages": "1-11", "issn-l": null}, "abstract": "The polymorphism L412F in TLR3 has been associated with several infectious diseases. However, the mechanism underlying this association is still unexplored. Here, we show that the L412F polymorphism in TLR3 is a marker of severity in COVID-19. This association increases in the sub-cohort of males. Impaired macroautophagy/autophagy and reduced TNF/TNF\u03b1 production was demonstrated in HEK293 cells transfected with TLR3L412F-encoding plasmid and stimulated with specific agonist poly(I:C). A statistically significant reduced survival at 28 days was shown in L412F COVID-19 patients treated with the autophagy-inhibitor hydroxychloroquine (p = 0.038). An increased frequency of autoimmune disorders such as co-morbidity was found in L412F COVID-19 males with specific class II HLA haplotypes prone to autoantigen presentation. Our analyses indicate that L412F polymorphism makes males at risk of severe COVID-19 and provides a rationale for reinterpreting clinical trials considering autophagy pathways.Abbreviations: AP: autophagosome; AUC: area under the curve; BafA1: bafilomycin A1; COVID-19: coronavirus disease-2019; HCQ: hydroxychloroquine; RAP: rapamycin; ROC: receiver operating characteristic; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2; TLR: toll like receptor; TNF/TNF-\u03b1: tumor necrosis factor.", "doi": "10.1080/15548627.2021.1995152", "pmid": "34964709", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:01:02.575Z", "modified": "2022-01-04T15:01:02.690Z"}, {"entity": "publication", "iuid": "d84e2dd02797453f8032f1c41fa1d769", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d84e2dd02797453f8032f1c41fa1d769.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d84e2dd02797453f8032f1c41fa1d769"}}, "title": "Fear of COVID-19, compliance with recommendations against virus transmission, and attitudes towards vaccination in Sweden.", "authors": [{"family": "H\u00e5kansson", "given": "A", "initials": "A"}, {"family": "Claesdotter", "given": "E", "initials": "E"}], "type": "journal article", "published": "2021-12-29", "journal": {"title": "Heliyon", "issn": "2405-8440", "pages": "e08699", "issn-l": null}, "abstract": "Following the immense impact of the COVID-19 pandemic on health and everyday lives world-wide, people's fear of COVID-19 has been studied in a number of settings using the Fear of COVID scale. In Sweden, virus-preventing strategies have differed from comparable countries, with low use of formal lock-down procedures. It is crucial to study correlates of non-compliance with COVID-19 recommendations, and unwillingness to become vaccinated. This study aims to study whether fear of COVID is associated with mental distress and attitudes towards the pandemic, and to study correlates of non-compliance with key anti-COVID recommendations and with reluctancy to vaccination. This anonymous online survey study in web panel participants (N=1,501) aimed to study a range of behavioral changes during COVID-19. Recommendations and vaccinations reluctancy were analyzed in logistic regressions against socio-demographic data, COVID-19 status, and mental health history. Internal consistency of the Fear of COVID scale was calculated. The Fear of COVID scale had a satisfactory internal consistency (Cronbach-alpha 0.84), and was significantly associated with compliance with all COVID-19 recommendations and with mental health. Non-compliance with recommendations was associated with low fear of disease and younger age, among other variables. Being against vaccination was associated, among other variables, with low fear of disease and with low education. In conclusion, the Fear of COVID scale appears to be associated with key attitudes towards the COVID-19 disease. Anti-virus strategies may need to promote compliance with recommendations in subgroups who feel low fear of disease or who believe not to be in a risk group for severe disease.", "doi": "10.1016/j.heliyon.2021.e08699", "pmid": "34981036", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)02802-4"}, {"db": "pmc", "key": "PMC8716143"}], "notes": [], "created": "2022-01-10T15:42:41.325Z", "modified": "2022-01-10T15:42:41.337Z"}, {"entity": "publication", "iuid": "694fdd8ecb754578a81e168adc034800", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/694fdd8ecb754578a81e168adc034800.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/694fdd8ecb754578a81e168adc034800"}}, "title": "Effect of Previous SARS-CoV-2 Infection on Antibody Response to a Single Immunization with the Pfizer BNT162b mRNA Vaccine Among Healthcare Workers in Foggia, Italy.", "authors": [{"family": "Homan", "given": "Tobias", "initials": "T"}, {"family": "Fortunato", "given": "Francesca", "initials": "F"}, {"family": "Corso", "given": "Gaetano", "initials": "G"}, {"family": "Lopalco", "given": "Pier Luigi", "initials": "PL"}, {"family": "Prato", "given": "Rosa", "initials": "R"}, {"family": "Martinelli", "given": "Domenico", "initials": "D", "orcid": "0000-0001-8028-3167", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84b47c38792d47a39a6ca9ff9d38f502.json"}}], "type": "journal article", "published": "2021-12-29", "journal": {"title": "Infect Dis Ther", "issn": "2193-8229", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Data have suggested that SARS-CoV-2 infection causes an antibody response at least as strong as one BNT162b2 vaccine dose. Nevertheless, some aspects require further investigation to better understand the immunogenicity of one vaccine dose among infected individuals. Thus, we evaluated how previous SARS-CoV-2 infection may influence the humoral immunity after a single Pfizer BNT162b mRNA vaccine dose in a sample of healthcare workers (HCWs).\n\nAs part of the routine surveillance activity conducted among HCWs of the Policlinico Riuniti Foggia Hospital (Apulia region, Italy), we conducted a retrospective serosurvey in the period January-March 2021. We compared specific antibody titres (anti-spike IgGs measured by enzyme-linked immunoassay, ELISA) after SARS-CoV-2 infection and after the first dose of the BNT162b2 vaccine, analysing the impact of sex, age, time since infection, and presence of symptoms on the humoral response.\n\nWe included in the study 58 HCWs (mean age 44.1 years, 48.2% male) with anti-spike IgG titres available before and after the first BNT162b2 vaccine dose. Among these, we observed higher titres in previously infected cases (N = 21) than in COVID-19-na\u00efve subjects (N = 37) (medians 1510 vs. 0.68; p < 0.001). A statistically significant difference in anti-spike IgG titres was also observed among previously infected HCWs before vaccine dose in comparison with post-dose infection-na\u00efve HCWs (medians 18.37 vs. 0.68, p < 0.001). Among infected individuals, no differences by sex, age, or time since infection were reported (p > 0.05). Post-dose titres of symptomatic and asymptomatic infected HCWs slightly differed (medians = 1900 vs. 1090; p = 0.048).\n\nOur data support the viable hypothesis of a single-dose vaccine regimen in individuals with a history of COVID-19, but no conclusion on duration of protection in this group can be drawn from our study.", "doi": "10.1007/s40121-021-00582-9", "pmid": "34964938", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40121-021-00582-9"}, {"db": "pmc", "key": "PMC8715151"}], "notes": [], "created": "2022-01-04T15:00:03.072Z", "modified": "2022-01-04T15:00:42.340Z"}, {"entity": "publication", "iuid": "8b6f545f64ee4f3b9bf47069406c68a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b6f545f64ee4f3b9bf47069406c68a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b6f545f64ee4f3b9bf47069406c68a2"}}, "title": "Biosensor-Enabled Deconvolution of the Avidity-Induced Affinity Enhancement for the SARS-CoV-2 Spike Protein and ACE2 Interaction.", "authors": [{"family": "Gutgsell", "given": "Aspen Rene", "initials": "AR"}, {"family": "Gunnarsson", "given": "Anders", "initials": "A"}, {"family": "Forss\u00e9n", "given": "Patrik", "initials": "P"}, {"family": "Gordon", "given": "Euan", "initials": "E"}, {"family": "Fornstedt", "given": "Torgny", "initials": "T", "orcid": "0000-0002-7123-2066", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53811bd2e7764434b2482324fc9cade9.json"}}, {"family": "Geschwindner", "given": "Stefan", "initials": "S", "orcid": "0000-0002-2154-8345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36d7770aaccf4324a28dc5166afb5eeb.json"}}], "type": "journal article", "published": "2021-12-29", "journal": {"title": "Anal Chem", "issn": "1520-6882", "issn-l": null}, "abstract": "Avidity is an effective and frequent phenomenon employed by nature to achieve extremely high-affinity interactions. As more drug discovery efforts aim to disrupt protein-protein interactions, it is becoming increasingly common to encounter systems that utilize avidity effects and to study these systems using surface-based technologies, such as surface plasmon resonance (SPR) or biolayer interferometry. However, heterogeneity introduced from multivalent binding interactions complicates the analysis of the resulting sensorgram. A frequently applied practice is to fit the data based on a 1:1 binding model, and if the fit does not describe the data adequately, then the experimental setup is changed to favor a 1:1 binding interaction. This reductionistic approach is informative but not always biologically relevant. Therefore, we aimed to develop an SPR-based assay that would reduce the heterogeneity to enable the determination of the kinetic rate constants for multivalent binding interactions using the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and the human receptor angiotensin-converting enzyme 2 (ACE2) as a model system. We employed a combinatorial approach to generate a sensor surface that could distinguish between monovalent and multivalent interactions. Using advanced data analysis algorithms to analyze the resulting sensorgrams, we found that controlling the surface heterogeneity enabled the deconvolution of the avidity-induced affinity enhancement for the SARS-CoV-2 spike protein and ACE2 interaction.", "doi": "10.1021/acs.analchem.1c04372", "pmid": "34964599", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:01:21.322Z", "modified": "2022-01-04T15:10:01.638Z"}, {"entity": "publication", "iuid": "ff01ddd3a9c243118b711c0d1af77ad4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff01ddd3a9c243118b711c0d1af77ad4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff01ddd3a9c243118b711c0d1af77ad4"}}, "title": "A hot topic at the environment-health nexus: Investigating the impact of climate change on infectious diseases.", "authors": [{"family": "Grobusch", "given": "Lena C", "initials": "LC"}, {"family": "Grobusch", "given": "Martin P", "initials": "MP"}], "type": "journal article", "published": "2021-12-29", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712"}, "abstract": "COVID-19 pandemic aside, climate change is the ultimate challenge of our time. However, to date, there has been insufficient political thrust to make that much-needed climate action a reality.\n\nInfectious diseases represent only one facet of the threats arising from climate change. Direct impacts from climate change include the more frequent occurrence and increased magnitude of extreme weather events, as well as changing temperatures and precipitation patterns. For climate-sensitive infectious diseases, these changes implicate a shift in geographic and temporal distribution, seasonality, and transmission intensity.\n\nSusceptibility to deleterious effects of climate change is a net result not only of the interplay of environmental factors but also governed by human, societal, and economic factors, with social inequalities being a major determinant of vulnerability. The global South is already disproportionately affected by the climate crisis. The financial capacity to pursue adaptation options is also limited and unevenly distributed.\n\nClimate change-induced mortality and morbidity from both infectious and non-infectious diseases, amongst other adverse scenarios, is expected to rise globally in the future. The coming decade will be crucial for using all opportunities left to develop and implement adequate mitigation- and adaptation strategies.", "doi": "10.1016/j.ijid.2021.12.350", "pmid": "34973415", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)01250-9"}], "notes": [], "created": "2022-01-04T14:45:52.481Z", "modified": "2022-01-04T14:45:52.494Z"}, {"entity": "publication", "iuid": "2eed46b16b7d48628da3742f43526c30", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2eed46b16b7d48628da3742f43526c30.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2eed46b16b7d48628da3742f43526c30"}}, "title": "Disturbances in sleep, circadian rhythms and daytime functioning in relation to coronavirus infection and Long-COVID - A multinational ICOSS study.", "authors": [{"family": "Merikanto", "given": "Ilona", "initials": "I", "orcid": "0000-0002-1222-6678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50ed32f3146e4c0aa13e934d46eeb4af.json"}}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y"}, {"family": "Chung", "given": "Frances", "initials": "F"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L", "orcid": "0000-0003-3613-6631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e700e607f114414dba66aa366e3158b6.json"}}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK", "orcid": "0000-0002-5745-5474", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bbe4815f36d48959f5e81a5cf650088.json"}}, {"family": "Korman", "given": "Maria", "initials": "M"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "2nd ICOSS members", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-28", "journal": {"title": "J Sleep Res", "issn": "1365-2869", "pages": "e13542", "issn-l": "0962-1105"}, "abstract": "This protocol paper describes the second survey produced by the International Covid Sleep Study (ICOSS) group with the aim to examine the associations between SARS-CoV-2 infection and sleep, sleepiness, and circadian problems as potential predisposing factors for more severe COVID-19 disease profile and for development of Long-COVID in the general population. The survey consists of 47 questions on sleep, daytime sleepiness, circadian rhythm, health, mental wellbeing, life habits, and socioeconomic situation before and during the pandemic, and conditional questions to those reporting having had coronavirus infection, being vaccinated, or suffering from particular sleep symptoms or sleep disorders. Surveys will be administered online between May and November 2021 in Austria, Brazil, Bulgaria, Canada, China, Croatia, Finland, France, Germany, Israel, Italy, Japan, Norway, Portugal, Sweden and USA. Data collected by the survey will give valuable information on the open questions regarding COVID-19 disease risk factors, symptomatology and evolution of Long-COVID, and on other long-term consequences related to the pandemic.", "doi": "10.1111/jsr.13542", "pmid": "34964184", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:10:20.693Z", "modified": "2022-01-04T15:10:20.746Z"}, {"entity": "publication", "iuid": "ff0ff881a2e04993b01ac47c9fa43740", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff0ff881a2e04993b01ac47c9fa43740.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff0ff881a2e04993b01ac47c9fa43740"}}, "title": "Impact of COVID-19 Lockdown in Eating Disorders: A Multicentre Collaborative International Study.", "authors": [{"family": "Baenas", "given": "Isabel", "initials": "I"}, {"family": "Etxandi", "given": "Mikel", "initials": "M"}, {"family": "Mungu\u00eda", "given": "Lucero", "initials": "L", "orcid": "0000-0002-9751-810X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c45fa0084904a0daa70185f2c205f93.json"}}, {"family": "Granero", "given": "Roser", "initials": "R", "orcid": "0000-0001-6308-3198", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fcdba2a95cdb4c6ca52341bb3eaa8cd6.json"}}, {"family": "Mestre-Bach", "given": "Gemma", "initials": "G", "orcid": "0000-0001-5345-0484", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4bfd9cd50f94f16ae65c3efcb320ef9.json"}}, {"family": "S\u00e1nchez", "given": "Isabel", "initials": "I"}, {"family": "Ortega", "given": "Emilio", "initials": "E", "orcid": "0000-0002-2217-8905", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/967b2d8a952d4a64a3431d6377c9d623.json"}}, {"family": "Andreu", "given": "Alba", "initials": "A", "orcid": "0000-0001-9854-1531", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1ad984c75d446bba8e0b0711f92d492.json"}}, {"family": "Moize", "given": "Violeta L", "initials": "VL"}, {"family": "Fern\u00e1ndez-Real", "given": "Jose-Manuel", "initials": "JM"}, {"family": "Tinahones", "given": "Francisco J", "initials": "FJ"}, {"family": "Di\u00e9guez", "given": "Carlos", "initials": "C"}, {"family": "Fr\u00fchbeck", "given": "Gema", "initials": "G", "orcid": "0000-0002-8305-7154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5f1175d35d1415eb468c233efea3a7d.json"}}, {"family": "Le Grange", "given": "Daniel", "initials": "D", "orcid": "0000-0001-7293-9496", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f4e9d3d0bb3e4d6bbcadb48755345a0b.json"}}, {"family": "Tchanturia", "given": "Kate", "initials": "K", "orcid": "0000-0001-8988-3265", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27ec6341a4ed4a0eb1b9d0b2b4ba26b4.json"}}, {"family": "Karwautz", "given": "Andreas", "initials": "A", "orcid": "0000-0001-9053-998X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6fa0398cf9494fb8a627efe84d8ea526.json"}}, {"family": "Zeiler", "given": "Michael", "initials": "M", "orcid": "0000-0002-7087-6134", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64a514e9d496437a9ca03b3487761c78.json"}}, {"family": "Imgart", "given": "Hartmut", "initials": "H"}, {"family": "Zanko", "given": "Annika", "initials": "A"}, {"family": "Favaro", "given": "Angela", "initials": "A"}, {"family": "Claes", "given": "Laurence", "initials": "L", "orcid": "0000-0002-2287-3158", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05668afa36ac44e0a41baefe3fe15627.json"}}, {"family": "Shekriladze", "given": "Ia", "initials": "I", "orcid": "0000-0002-2787-0503", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6cbb53e06b24d05b7a06e27abe4025c.json"}}, {"family": "Serrano-Troncoso", "given": "Eduardo", "initials": "E"}, {"family": "Cecilia-Costa", "given": "Raquel", "initials": "R"}, {"family": "Rangil", "given": "Teresa", "initials": "T"}, {"family": "Loran-Meler", "given": "Maria Eulalia", "initials": "ME"}, {"family": "Soriano-Pacheco", "given": "Jos\u00e9", "initials": "J"}, {"family": "Carceller-Sindreu", "given": "Mar", "initials": "M"}, {"family": "Navarrete", "given": "Rosa", "initials": "R"}, {"family": "Lozano", "given": "Meritxell", "initials": "M"}, {"family": "Linares", "given": "Raquel", "initials": "R"}, {"family": "Gudiol", "given": "Carlota", "initials": "C"}, {"family": "Carratala", "given": "Jordi", "initials": "J", "orcid": "0000-0003-3209-2563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/457c5afc94f04abf8213883af22e6881.json"}}, {"family": "Plana", "given": "Maria T", "initials": "MT"}, {"family": "Graell", "given": "Montserrat", "initials": "M"}, {"family": "Gonz\u00e1lez-Parra", "given": "David", "initials": "D"}, {"family": "G\u00f3mez-Del Barrio", "given": "Jos\u00e9 A", "initials": "JA", "orcid": "0000-0002-0843-2575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6859029c9c794890b4c413182e6ebd6d.json"}}, {"family": "Sep\u00falveda", "given": "Ana R", "initials": "AR", "orcid": "0000-0002-6041-2889", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17286862c654184bd6d2c372ed2dd34.json"}}, {"family": "S\u00e1nchez-Gonz\u00e1lez", "given": "J\u00e9ssica", "initials": "J"}, {"family": "Machado", "given": "Paulo P P", "initials": "PPP", "orcid": "0000-0003-4277-9203", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78c76a513fda475389e9733feed37285.json"}}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A", "orcid": "0000-0002-5800-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec14ecdcc0654d8ea864f64ce195752b.json"}}, {"family": "T\u00fary", "given": "Ferenc", "initials": "F", "orcid": "0000-0002-7283-5088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6552d5b04a814f7ca33d605d11bb6066.json"}}, {"family": "P\u00e1szthy", "given": "Bea", "initials": "B"}, {"family": "Stein", "given": "Daniel", "initials": "D"}, {"family": "Papezov\u00e1", "given": "Hana", "initials": "H"}, {"family": "Gricova", "given": "Jana", "initials": "J"}, {"family": "Bax", "given": "Brigita", "initials": "B"}, {"family": "Borisenkov", "given": "Mikhail F", "initials": "MF", "orcid": "0000-0002-4310-2010", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9cefa16d6c14d8fbbef76031166b08b.json"}}, {"family": "Popov", "given": "Sergey V", "initials": "SV", "orcid": "0000-0003-1763-8898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/740f23b384674f6681e744c38593bc32.json"}}, {"family": "Gubin", "given": "Denis G", "initials": "DG"}, {"family": "Petrov", "given": "Ivan M", "initials": "IM", "orcid": "0000-0003-0823-3434", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54707d4b6a1c43dd8ced55e544ecbdc8.json"}}, {"family": "Isakova", "given": "Dilara", "initials": "D"}, {"family": "Mustafina", "given": "Svetlana V", "initials": "SV", "orcid": "0000-0003-4716-876X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3822f19c5c474c4784a6cf63b18bfe8f.json"}}, {"family": "Kim", "given": "Youl-Ri", "initials": "YR"}, {"family": "Nakazato", "given": "Michiko", "initials": "M", "orcid": "0000-0002-4025-7594", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1b76b8cf7c947cd96fb042248ab8d71.json"}}, {"family": "Godart", "given": "Nathalie", "initials": "N"}, {"family": "van Voren", "given": "Robert", "initials": "R"}, {"family": "Ilnytska", "given": "Tetiana", "initials": "T", "orcid": "0000-0003-1734-1568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dfd94d8f0d0b43e5abf6732f7b8b7362.json"}}, {"family": "Chen", "given": "Jue", "initials": "J"}, {"family": "Rowlands", "given": "Katie", "initials": "K"}, {"family": "Voderholzer", "given": "Ulrich", "initials": "U", "orcid": "0000-0003-0261-3145", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07d8956c0b9942559bf43303a1df32d5.json"}}, {"family": "Monteleone", "given": "Alessio M", "initials": "AM"}, {"family": "Treasure", "given": "Janet", "initials": "J"}, {"family": "Jim\u00e9nez-Murcia", "given": "Susana", "initials": "S", "orcid": "0000-0002-3596-8033", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ac03a841eb041898475d397a496f40d.json"}}, {"family": "Fern\u00e1ndez-Aranda", "given": "Fernando", "initials": "F", "orcid": "0000-0002-2968-9898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc6962e9696f4bb68aac669a99db8ad6.json"}}], "type": "journal article", "published": "2021-12-27", "journal": {"title": "Nutrients", "issn": "2072-6643", "volume": "14", "issue": "1", "issn-l": null}, "abstract": "The COVID-19 lockdown has had a significant impact on mental health. Patients with eating disorders (ED) have been particularly vulnerable.\n\n(1) To explore changes in eating-related symptoms and general psychopathology during lockdown in patients with an ED from various European and Asian countries; and (2) to assess differences related to diagnostic ED subtypes, age, and geography.\n\nThe sample comprised 829 participants, diagnosed with an ED according to DSM-5 criteria from specialized ED units in Europe and Asia. Participants were assessed using the COVID-19 Isolation Scale (CIES).\n\nPatients with binge eating disorder (BED) experienced the highest impact on weight and ED symptoms in comparison with other ED subtypes during lockdown, whereas individuals with other specified feeding and eating disorders (OFSED) had greater deterioration in general psychological functioning than subjects with other ED subtypes. Finally, Asian and younger individuals appeared to be more resilient.\n\nThe psychopathological changes in ED patients during the COVID-19 lockdown varied by cultural context and individual variation in age and ED diagnosis. Clinical services may need to target preventive measures and adapt therapeutic approaches for the most vulnerable patients.", "doi": "10.3390/nu14010100", "pmid": "35010974", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "nu14010100"}], "notes": [], "created": "2022-01-13T21:06:58.879Z", "modified": "2022-01-13T21:06:59.811Z"}, {"entity": "publication", "iuid": "d488e23ab7044f878bd2c3574727a9a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d488e23ab7044f878bd2c3574727a9a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d488e23ab7044f878bd2c3574727a9a2"}}, "title": "Disease severity related to VOC dominance in unvaccinated SARS-CoV-2 positive adults without risk factors in Sweden", "authors": [{"family": "Wahlstr\u00f6m", "given": "Erik", "initials": "E", "orcid": "0000-0002-0800-8520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f623177f84a4f4ba85571b106e4cec5.json"}}, {"family": "Bruce", "given": "Daniel", "initials": "D"}, {"family": "Bennet Bark", "given": "Anna M", "initials": "AM"}, {"family": "Walther", "given": "Sten", "initials": "S"}, {"family": "Hanberger", "given": "H\u00e5kan", "initials": "H", "orcid": "0000-0002-4199-0229", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ccccceb630874fc5ab7507a313b59039.json"}}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-8801-3169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37509c3832244b019b91a1fe2cbe183e.json"}}], "type": "posted-content", "published": "2021-12-27", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.12.23.21268040", "pmid": null, "labels": {"Type: Preprint": null, "Category: Vaccines": null, "Category: Health": null, "Funder: VR": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:42:57.654Z", "modified": "2022-01-04T15:43:35.405Z"}, {"entity": "publication", "iuid": "0814a4ea41f54f73a151983bdea6511c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0814a4ea41f54f73a151983bdea6511c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0814a4ea41f54f73a151983bdea6511c"}}, "title": "Clinical grade ACE2 effectively inhibits SARS-CoV-2 Omicron infections", "authors": [{"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Stephanie", "given": "Devignot", "initials": "D"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Kellner", "given": "Max J", "initials": "MJ"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Mereiter", "given": "Stefan", "initials": "S"}, {"family": "Knapp", "given": "Sylvia", "initials": "S"}, {"family": "Montserrat", "given": "Nuria", "initials": "N"}, {"family": "Braunsfeld", "given": "Benedict", "initials": "B"}, {"family": "Kozieradzki", "given": "Ivona", "initials": "I"}, {"family": "Ali", "given": "Omar Hasan", "initials": "OH"}, {"family": "Hagelkruys", "given": "Astrid", "initials": "A"}, {"family": "Stadlmann", "given": "Johannes", "initials": "J"}, {"family": "Oostenbrink", "given": "Chris", "initials": "C"}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}], "type": "posted-content", "published": "2021-12-27", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.12.25.474113", "pmid": null, "labels": {"Category: Health": null, "Type: Preprint": null, "Category: Biochemistry": null, "Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null, "Category: Omicron VoC": null}, "xrefs": [], "notes": [], "created": "2022-01-17T10:10:34.079Z", "modified": "2022-01-21T16:21:24.414Z"}, {"entity": "publication", "iuid": "82393755f88348d28f9b87e3f8855197", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82393755f88348d28f9b87e3f8855197.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82393755f88348d28f9b87e3f8855197"}}, "title": "Brand-Specific Enhanced Safety Surveillance Study of GSK's Quadrivalent Seasonal Influenza Vaccine, Conducted During the COVID-19 Pandemic, in Belgium, Germany and Spain, for the 2020/21 Season.", "authors": [{"family": "Dos Santos", "given": "Ga\u00ebl", "initials": "G", "orcid": "0000-0001-8623-3478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e24881d9d6a54aebbc46d19ecd6db87b.json"}}, {"family": "Wang", "given": "Hao", "initials": "H", "orcid": "0000-0001-8293-6969", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1b2f6e2c99943c4ad8699c47c7ffdad.json"}}, {"family": "Jindal", "given": "Pooja", "initials": "P", "orcid": "0000-0001-6528-8875", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ac2ddaacf10499aa5215402e247e31d.json"}}, {"family": "Rybo", "given": "Maria", "initials": "M", "orcid": "0000-0002-6678-0455", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822d718fbc3c49778221473c87ed2c16.json"}}, {"family": "Roul", "given": "H\u00e9l\u00e8ne", "initials": "H", "orcid": "0000-0001-9912-6540", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73b2d969cf3b411ea76655257410a811.json"}}, {"family": "Pallem", "given": "Sridevi", "initials": "S", "orcid": "0000-0002-8435-7132", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f3e1c7911a142f18c155f04959746bc.json"}}, {"family": "Eckermann", "given": "Tamara", "initials": "T"}, {"family": "Godderis", "given": "Lode", "initials": "L", "orcid": "0000-0003-4764-8835", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/639b8bdac78742e9aeebe5b33c6dfedb.json"}}, {"family": "Mart\u00ednez G\u00f3mez", "given": "Xavier", "initials": "X", "orcid": "0000-0003-4583-9734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/17a4aee6258946b388292ad1a0d9255a.json"}}, {"family": "Godard", "given": "Eric", "initials": "E"}, {"family": "Soler", "given": "Muriel", "initials": "M", "orcid": "0000-0002-8169-0730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/63db46695baa4e3c8652cdf990f65d9b.json"}}, {"family": "Yousefi", "given": "Mitra", "initials": "M", "orcid": "0000-0003-3076-5701", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31e3ce5af02d4535aaaf6f440b77e8e7.json"}}, {"family": "Salamanca de la Cueva", "given": "Ignacio", "initials": "I", "orcid": "0000-0003-0561-9913", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ecdb4aaf428b40c78ab014c41fa8e320.json"}}, {"family": "Nwoji", "given": "Ugo", "initials": "U", "orcid": "0000-0002-2946-703X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e630d6f34a914319ba2dd25204adb0fc.json"}}], "type": "journal article", "published": "2021-12-27", "journal": {"title": "Infect Dis Ther", "issn": "2193-8229", "issn-l": null}, "abstract": "Seasonal influenza poses a major public health burden worldwide. Influenza vaccines, updated yearly to match circulating strains based on World Health Organization (WHO) recommendations, are the cornerstone of prevention and require regular monitoring. The COVID-19 pandemic is expected to cause logistical, site access and medical staff constraints and could affect the safety profile of influenza vaccines.\n\nFollowing European Medicines Agency guidance, an enhanced safety surveillance (ESS) study assessed the frequency and severity of predefined and other adverse events (AEs) occurring within 7 days of receiving GSK's inactivated quadrivalent seasonal influenza vaccine (IIV4), in Belgium, Germany and Spain in 2020/21, using adverse drug reaction (ADR) cards.\n\nDuring the 2020/21 influenza season, 1054 participants vaccinated with GSK's IIV4 were enrolled (all adults in Belgium and Germany, 30% adults/70% children in Spain); 96 eligible children received a second dose. Overall, 1042 participants completed the study. After doses 1 and 2, 98.9% and 100% of participants, respectively, returned their completed ADR card. After doses 1 and 2, 37.8% (398/1054) and 13.5% (13/96) of participants, respectively, reported at least one AE. The most frequently reported categories of AEs were \"general disorders and administration site conditions\" (e.g. injection site pain) and \"nervous system disorders\" (e.g. headache). There were no deaths or serious AEs deemed related to GSK's IIV4.\n\nThis ESS study assessed AEs in near real time. The COVID-19 pandemic did not alter the safety profile of GSK's IIV4. No safety signals were detected during the study, which confirms the excellent safety profile of GSK's IIV4.", "doi": "10.1007/s40121-021-00571-y", "pmid": "34961900", "labels": {"Category: Post-COVID": null, "Category: Vaccines": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40121-021-00571-y"}, {"db": "pmc", "key": "PMC8711683"}], "notes": [], "created": "2022-01-04T15:10:47.472Z", "modified": "2022-01-04T15:10:47.851Z"}, {"entity": "publication", "iuid": "339ebb8c228e4553bec7ec6e3ad6f6c8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/339ebb8c228e4553bec7ec6e3ad6f6c8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/339ebb8c228e4553bec7ec6e3ad6f6c8"}}, "title": "A large scale meta-analytic atlas of mental health problems prevalence during the COVID-19 early pandemic.", "authors": [{"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Li", "given": "Han", "initials": "H"}, {"family": "Tsitsas", "given": "George", "initials": "G"}, {"family": "Lee", "given": "Keum Hwa", "initials": "KH"}, {"family": "Choi", "given": "Jiwoo", "initials": "J"}, {"family": "Kim", "given": "Jiwon", "initials": "J"}, {"family": "Choi", "given": "Young Jo", "initials": "YJ"}, {"family": "Tsamakis", "given": "Konstantinos", "initials": "K"}, {"family": "Estrad\u00e9", "given": "Andr\u00e9s", "initials": "A"}, {"family": "Agorastos", "given": "Agorastos", "initials": "A"}, {"family": "Vancampfort", "given": "Davy", "initials": "D"}, {"family": "Tsiptsios", "given": "Dimitrios", "initials": "D"}, {"family": "Thompson", "given": "Trevor", "initials": "T"}, {"family": "Mosina", "given": "Anna", "initials": "A"}, {"family": "Vakadaris", "given": "Georgios", "initials": "G"}, {"family": "Fusar-Poli", "given": "Paolo", "initials": "P"}, {"family": "Carvalho", "given": "Andre F", "initials": "AF"}, {"family": "Correll", "given": "Christoph U", "initials": "CU"}, {"family": "Han", "given": "Young Joo", "initials": "YJ"}, {"family": "Park", "given": "Seoyeon", "initials": "S"}, {"family": "Il Shin", "given": "Jae", "initials": "J"}, {"family": "Solmi", "given": "Marco", "initials": "M"}], "type": "journal article", "published": "2021-12-27", "journal": {"title": "J Med Virol", "issn": "1096-9071", "issn-l": null}, "abstract": "The COVID-19 pandemic and related restrictions can impact mental health. In order to quantify the mental health burden of COVID-19 pandemic, we conducted a systematic review and meta-analysis, searching World Health Organization COVID-19/PsycInfo/PubMed databases (09/29/2020), including observational studies reporting on mental health outcomes in any population affected by COVID-19. Primary outcomes were the prevalence of anxiety, depression, stress, sleep problems, post-traumatic symptoms. Sensitivity analyses were conducted on severe mental health problems, in high-quality studies, and in representative samples. Subgroup analyses were conducted stratified by age, sex, country income level, and COVID-19 infection status. One-hundred-seventy-three studies from February-July 2020 were included (n=502,261, median sample=948, age=34.4 years, females=63%). Ninety-one percent were cross-sectional studies, and 18.5%/57.2% were of high/moderate quality. Highest prevalence emerged for post-traumatic symptoms in COVID-19 infected people (94%), followed by behavioural problems in those with prior mental disorders (77%), fear in healthcare workers (71%), anxiety in caregivers/family members of people with COVID-19 (42%), general health/social contact/passive coping style in the general population (38%), depression in those with prior somatic disorders (37%), and fear in other-than-healthcare workers (29%). Females and people with COVID-19 infection had higher rates of almost all outcomes; college students/young adults of anxiety, depression, sleep problems, suicidal ideation; adults of fear and post-traumatic symptoms. Anxiety, depression, and post-traumatic symptoms were more prevalent in low-/middle-income countries, sleep problems in high-income countries. The COVID-19 pandemic adversely impacts mental health in unique manners across population subgroups. Our results inform tailored preventive strategies and interventions to mitigate current, future, and transgenerational adverse mental health of the COVID-19 pandemic. This article is protected by copyright. All rights reserved.", "doi": "10.1002/jmv.27549", "pmid": "34958144", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:24:01.051Z", "modified": "2022-01-04T15:24:28.475Z"}, {"entity": "publication", "iuid": "12990ec8a3de4a1cb085b315d2fe3209", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/12990ec8a3de4a1cb085b315d2fe3209.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/12990ec8a3de4a1cb085b315d2fe3209"}}, "title": "Validating Insomnia Severity Index (ISI) in a Bangladeshi Population: Using Classical Test Theory and Rasch Analysis.", "authors": [{"family": "Mamun", "given": "Mohammed A", "initials": "MA", "orcid": "0000-0002-1728-8966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6e65a5a97154d159a63cc2ce3f1b7a8.json"}}, {"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Gozal", "given": "David", "initials": "D", "orcid": "0000-0001-8195-6036", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50940954296643fabb4d15a69d4e4bb4.json"}}, {"family": "Manzar", "given": "Md Dilshad", "initials": "MD", "orcid": "0000-0002-5571-3310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/003777905ef4485fa4fd18c9f0cc16ec.json"}}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Huang", "given": "Ru-Yi", "initials": "RY", "orcid": "0000-0001-6867-7171", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3169b8bbbc4f4409961cbd2cf47b2c6b.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-12-25", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "1", "issn-l": null}, "abstract": "The COVID-19 outbreak is associated with sleep problems and mental health issues among individuals. Therefore, there is a need to assess sleep efficiency during this tough period. Unfortunately, the commonly used instrument on insomnia severity-the Insomnia Severity Index (ISI)-has never been translated and validated among Bangladeshis. Additionally, the ISI has never been validated during a major protracted disaster (such as the COVID-19 outbreak) when individuals encounter mental health problems. The present study aimed to translate the ISI into Bangla language (ISI-Bangla) and validate its psychometric properties. First, the linguistic validity of the ISI-Bangla was established. Then, 9790 Bangladeshis (mean age = 26.7 years; SD = 8.5; 5489 [56.1%] males) completed the Bangla versions of the following questionnaires: ISI, Fear of COVID-19 Scale (FCV-19S), and Patient Health Questionnaire-9 (PHQ-9). All the participants also answered an item on suicidal ideation. Classical test theory and Rasch analyses were conducted to evaluate the psychometric properties of the ISI-Bangla. Both classical test theory and Rasch analyses support a one-factor structure for the ISI-Bangla. Moreover, no substantial differential item functioning was observed across different subgroups (gender, depression status (determined using PHQ-9), and suicidal ideation). Additionally, concurrent validity of the ISI-Bangla was supported by significant and moderate correlations with FCV-19S and PHQ-9; known-group validity was established by the significant difference of the ISI-Bangla scores between participants who experienced suicidal ideation and those without. The present psychometric validation conducted during the COVID-19 outbreak suggests that the ISI-Bangla is a promising and operationally adequate instrument to assess insomnia in Bangladeshis.", "doi": "10.3390/ijerph19010225", "pmid": "35010485", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph19010225"}], "notes": [], "created": "2022-01-13T21:08:26.021Z", "modified": "2022-01-13T21:08:26.201Z"}, {"entity": "publication", "iuid": "d3698936851f43e5bff38669fd8afc2e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3698936851f43e5bff38669fd8afc2e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3698936851f43e5bff38669fd8afc2e"}}, "title": "Surgical helmets can be converted into efficient disinfectable powered air-purifying respirators.", "authors": [{"family": "Temmesfeld", "given": "Max", "initials": "M"}, {"family": "Gorzkowska-Sobas", "given": "Agnieszka Anna", "initials": "AA"}, {"family": "Hedlund", "given": "Kenny", "initials": "K"}, {"family": "\u00d8yen", "given": "Martin \u00d8hlund", "initials": "M\u00d8"}, {"family": "Kanten", "given": "Lars", "initials": "L"}, {"family": "Grant", "given": "Peter", "initials": "P"}, {"family": "Jakobsen", "given": "Rune B", "initials": "RB"}], "type": "journal article", "published": "2021-12-25", "journal": {"title": "Am J Infect Control", "issn": "1527-3296", "issn-l": null}, "abstract": "Filtering facepiece respirators often fail to provide sufficient protection due to a poor fit. Powered air-purifying respirators (PAPRs) are not designed for healthcare personnel, and are challenging to disinfect. Surgical helmets (SH) are available in many US hospitals but do not provide respiratory protection. Several modifications to SH have been suggested, but none are sufficiently compliant with safety and efficiency standards. The purpose of this investigation was the development of a filter adaptor, which converts SHs into efficient, safe and disinfectable PAPRs.\n\nFour critical features were investigated close to regulatory requirements: total inward leakage (TIL) of particles, CO2 concentrations, intra-helmet differential pressure, and automated disinfection.\n\nThe average TIL in the two independent tests were 0.005% and 0.01%. CO2 concentrations were lower than in the original SH. The modification generates a positive differential pressure. The filter's performance was not compromised after 50 cycles in a sterilization machine.\n\nThe modified SH provides several hundred times better protection than FFP-3 masks.\n\nSurgical helmets can be modified into safe, efficient, and disinfectable PAPRs, suitable for HCP and the OR in particular. They can play a role in the preparedness for upcoming events requiring efficient respiratory protection.", "doi": "10.1016/j.ajic.2021.12.002", "pmid": "34958857", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0196-6553(21)00841-5"}], "notes": [], "created": "2022-01-04T15:23:41.932Z", "modified": "2022-01-04T15:23:41.946Z"}, {"entity": "publication", "iuid": "492db880c06643539af84fc60d1a3e89", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/492db880c06643539af84fc60d1a3e89.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/492db880c06643539af84fc60d1a3e89"}}, "title": "Influenza A H1N1\u2013mediated pre-existing immunity to SARS-CoV-2 predicts COVID-19 outbreak dynamics", "authors": [{"family": "Almaz\u00e1n", "given": "Nerea Mart\u00edn", "initials": "NM"}, {"family": "Rahbar", "given": "Afsar", "initials": "A"}, {"family": "Carlsson", "given": "Marcus", "initials": "M"}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Kolstad", "given": "Linda", "initials": "L"}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B"}, {"family": "Pantalone", "given": "Mattia Russel", "initials": "MR"}, {"family": "Fuchs", "given": "Ilona Lewensohn", "initials": "IL"}, {"family": "Naucl\u00e9r", "given": "Anna", "initials": "A"}, {"family": "Ohlin", "given": "Mats", "initials": "M"}, {"family": "Sacharczuk", "given": "Mariusz", "initials": "M"}, {"family": "Religa", "given": "Piotr", "initials": "P"}, {"family": "Am\u00e9r", "given": "Stefan", "initials": "S"}, {"family": "Moln\u00e1r", "given": "Christian", "initials": "C"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Susrud", "given": "Andres", "initials": "A"}, {"family": "S\u00f6rensen", "given": "Birger", "initials": "B"}, {"family": "S\u00f6derberg-Naucl\u00e9r", "given": "Cecilia", "initials": "C"}], "type": "posted-content", "published": "2021-12-25", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.12.23.21268321", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null, "Category: Genomics & transcriptomics": null, "Funder: KAW/SciLifeLab": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Drug discovery and repurposing of drugs": null, "Category: Omicron VoC": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:44:30.390Z", "modified": "2022-02-14T14:40:41.897Z"}, {"entity": "publication", "iuid": "28e70e03c04d4f56aa48b44cb2361a06", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/28e70e03c04d4f56aa48b44cb2361a06.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/28e70e03c04d4f56aa48b44cb2361a06"}}, "title": "Acute Stress in Health Workers during Two Consecutive Epidemic Waves of COVID-19.", "authors": [{"family": "J\u00e1uregui Renaud", "given": "Kathrine", "initials": "K", "orcid": "0000-0002-2165-1422", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15f62be9e24a4fac9cdbcdeaafcdf713.json"}}, {"family": "Cooper-Bribiesca", "given": "Davis", "initials": "D", "orcid": "0000-0002-4273-1181", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a29e74edc3fd4cad8860996e46014d6f.json"}}, {"family": "Mart\u00ednez-Pichardo", "given": "Elizabet", "initials": "E"}, {"family": "Miguel Puga", "given": "Jos\u00e9 A", "initials": "JA"}, {"family": "Rasc\u00f3n-Mart\u00ednez", "given": "Dulce M", "initials": "DM", "orcid": "0000-0002-3074-679X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ecd8f18e63eb4506b0ac6bfbcf01c4da.json"}}, {"family": "S\u00e1nchez Hurtado", "given": "Luis A", "initials": "LA"}, {"family": "Colin Mart\u00ednez", "given": "Tania", "initials": "T"}, {"family": "Espinosa-Poblano", "given": "Eliseo", "initials": "E"}, {"family": "Anda-Garay", "given": "Juan Carlos", "initials": "JC"}, {"family": "Gonz\u00e1lez Diaz", "given": "Jorge I", "initials": "JI"}, {"family": "Carde\u00f1a", "given": "Etzel", "initials": "E"}, {"family": "Avelar Garnica", "given": "Francisco", "initials": "F"}], "type": "journal article", "published": "2021-12-25", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "1", "issn-l": null}, "abstract": "The COVID-19 pandemic has provoked generalized uncertainty around the world, with health workers experiencing anxiety, depression, burnout, insomnia, and stress. Although the effects of the pandemic on mental health may change as it evolves, the majority of reports have been web-based, cross-sectional studies. We performed a study assessing acute stress in frontline health workers during two consecutive epidemic waves. After screening for trait anxiety/depression and dissociative experiences, we evaluated changes in acute stress, considering resilience, state anxiety, burnout, depersonalization/derealization symptoms, and quality of sleep as cofactors. During the first epidemic wave (April 2020), health workers reported acute stress related to COVID-19, which was related to state anxiety. After the first epidemic wave, acute stress decreased, with no increase during the second epidemic wave (December 2020), and further decreased when vaccination started. During the follow-up (April 2020 to February 2021), the acute stress score was related to bad quality of sleep. However, acute stress, state anxiety, and burnout were all related to trait anxiety/depression, while the resilience score was invariant through time. Overall, the results emphasize the relevance of mental health screening before, during, and after an epidemic wave of infections, in order to enable coping during successive sanitary crises.", "doi": "10.3390/ijerph19010206", "pmid": "35010465", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph19010206"}], "notes": [], "created": "2022-01-13T21:08:44.552Z", "modified": "2022-01-13T21:08:44.686Z"}, {"entity": "publication", "iuid": "c7a4115a060d4271ae3121c23213beaf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7a4115a060d4271ae3121c23213beaf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7a4115a060d4271ae3121c23213beaf"}}, "title": "The incidence of melanoma during the COVID-19 pandemic in a Swedish health care region without lockdown.", "authors": [{"family": "Pissa", "given": "Maria", "initials": "M"}, {"family": "Gulin", "given": "Sandra Jerkovic", "initials": "SJ"}], "type": "journal article", "published": "2021-12-24", "journal": {"title": "JAAD Int", "issn": "2666-3287", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jdin.2021.12.004", "pmid": "34977816", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-3287(21)00104-8"}, {"db": "pmc", "key": "PMC8702400"}], "notes": [], "created": "2022-01-04T14:44:22.298Z", "modified": "2022-01-04T14:44:22.336Z"}, {"entity": "publication", "iuid": "6f7c3e78cc6a451989d470d385d4948e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f7c3e78cc6a451989d470d385d4948e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f7c3e78cc6a451989d470d385d4948e"}}, "title": "SARS-CoV-2 Post Vaccinated Adverse Effects and Efficacy in the Egyptian Population.", "authors": [{"family": "Elgendy", "given": "Marwa O", "initials": "MO", "orcid": "0000-0002-5466-0552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/092137ee2845486aa4c0a926a2d4c0a2.json"}}, {"family": "El-Gendy", "given": "Ahmed O", "initials": "AO", "orcid": "0000-0002-0980-5185", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37a05711bd4f4a67bd6af36f6df989e6.json"}}, {"family": "Alzarea", "given": "Abdulaziz Ibrahim", "initials": "AI", "orcid": "0000-0003-0604-6299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb86c921515b4f69b3ee4a9c496ee44e.json"}}, {"family": "Mahmoud", "given": "Sarah", "initials": "S"}, {"family": "Alqahtani", "given": "Saad S", "initials": "SS"}, {"family": "Fahmy", "given": "Alzhraa M", "initials": "AM"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}, {"family": "Sayed", "given": "Ahmed M", "initials": "AM", "orcid": "0000-0002-1442-183X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/013ee0ba73bb4d7f87fd285c65e49725.json"}}, {"family": "Alatawi", "given": "Ahmed D", "initials": "AD"}, {"family": "Abdelrahim", "given": "Mohamed E A", "initials": "MEA", "orcid": "0000-0003-0227-8404", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/feb86f846aee415dac74ef2f455ecb42.json"}}, {"family": "Alanazi", "given": "Abdullah S", "initials": "AS", "orcid": "0000-0002-8120-4018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22f197492bd64d478a6c5ac6072708c6.json"}}], "type": "journal article", "published": "2021-12-24", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "1", "issn-l": null}, "abstract": "Vaccines are the solution to overcome SARS-CoV-2. This study aimed to determine the post-Sinopharm vaccine safety-profile and immunity through antibody titers. Data were collected using a structured questionnaire from Egyptian participants who received two doses of Sinopharm vaccine. Data were divided into three parts, the first and second parts were to detect participants' post-first and second dose symptoms and practices, and the third for the results of IgG anti spike protein antibodies test and laboratory tests. Pain, redness, swelling at the injection site, headache, fatigue, and lethargy were the most common post-vaccine symptoms for both first and second doses. Most of the participants felt mild or no symptoms after vaccination. The symptoms started mostly during the first day post-vaccination and lasted for no more than two days. Forty-nine percent of the participants resulted in positive antibodies tests on day 18 post-vaccination. The average antibody level for vaccinated participants with past SARS-CoV-2 infection was much higher than that for non-past infected participants. These vaccines' administration methods need to be reevaluated by changing the dose, dose interval, adding a third dose, or mixing it with other vaccines with different techniques to improve their protection rates. Further studies are required to validate this finding.", "doi": "10.3390/vaccines10010018", "pmid": "35062679", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "vaccines10010018"}], "notes": [], "created": "2022-01-26T10:19:21.276Z", "modified": "2022-01-26T10:19:42.647Z"}, {"entity": "publication", "iuid": "a7d9bdf7e3a041e482c3586e9755e774", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7d9bdf7e3a041e482c3586e9755e774.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7d9bdf7e3a041e482c3586e9755e774"}}, "title": "Personal Social Networks of Community-Dwelling Oldest Old During the Covid-19 Pandemic-A Qualitative Study.", "authors": [{"family": "Kulmala", "given": "Jenni", "initials": "J"}, {"family": "Tiilikainen", "given": "Elisa", "initials": "E"}, {"family": "Lisko", "given": "Inna", "initials": "I"}, {"family": "Ngandu", "given": "Tiia", "initials": "T"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Solomon", "given": "Alina", "initials": "A"}], "type": "journal article", "published": "2021-12-24", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "770965", "issn-l": "2296-2565"}, "abstract": "The COVID-19 pandemic and its related restrictions have affected the everyday life of older people. Advanced age is a significant predisposing factor for a more severe COVID-19 infection, increasing the risk for hospitalization and mortality. Even though restrictions have been, thus, well-grounded, they may also have had detrimental effects on the social well-being of older people. Personal networks and social activity are known protective factors against the premature decline in health and functioning, and it is widely acknowledged that social isolation increases feelings of loneliness, poor quality of life, and even the risk for diseases and disabilities among older adults. This qualitative study investigated changes in personal networks among community-dwelling oldest-old individuals (persons aged 80 and over) during the first and second waves of the COVID-19 pandemic in Finland. The data is part of the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE85+) study, which is an ongoing large longitudinal population-based study in Finland. In this qualitative sub-study, we analyzed fifteen in-depth telephone interviews using directed content analyses and identified five types of changes in personal social networks during the pandemic. In type 1, all social contacts were significantly reduced due to official recommendations and fear of the virus. Type 2 included modified ways of being socially active i.e., by deploying new technology, and in type 3, social contacts increased during the lockdown. In type 4, personal social networks were changed unexpectedly or dramatically due to a death of a spouse, for example. In type 5, we observed stable social networks, which had not been affected by the pandemic. At an individual level, one person could have had different types of changes during the pandemic. These results highlight the heterogeneity of the oldest olds' personal social networks and changes related to them during the exceptional times of the COVID-19 pandemic. Social activity and personal networks play an important role in the well-being of the oldest old, but individual situations, needs, and preferences toward personal social networks should be taken into account when planning social activities, policies, and interventions.", "doi": "10.3389/fpubh.2021.770965", "pmid": "35004583", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8739883"}], "notes": [], "created": "2022-01-13T21:10:36.758Z", "modified": "2022-01-13T21:10:36.774Z"}, {"entity": "publication", "iuid": "67e12edf73e84fa38eb02d787339cf33", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/67e12edf73e84fa38eb02d787339cf33.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/67e12edf73e84fa38eb02d787339cf33"}}, "title": "COVID-19 and stillbirth: direct vs indirect effect of the pandemic.", "authors": [{"family": "Khalil", "given": "A", "initials": "A", "orcid": "0000-0003-2802-7670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e4558e368114cfb83c4594f523b38c0.json"}}, {"family": "Blakeway", "given": "H", "initials": "H"}, {"family": "Samara", "given": "A", "initials": "A"}, {"family": "O'Brien", "given": "P", "initials": "P"}], "type": "journal article", "published": "2021-12-24", "journal": {"title": "Ultrasound Obstet Gynecol", "issn": "1469-0705", "issn-l": null}, "abstract": null, "doi": "10.1002/uog.24846", "pmid": "34951732", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:26:30.102Z", "modified": "2022-01-04T15:26:30.156Z"}, {"entity": "publication", "iuid": "0f880ab1d5454514afb4045f0c9a7704", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0f880ab1d5454514afb4045f0c9a7704.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0f880ab1d5454514afb4045f0c9a7704"}}, "title": "Response to Letter to the Editor: Comment on \"Body mass index and Mini Nutritional Assessment-Short Form as predictors of in-geriatric hospital mortality in older adults with COVID-19\" (by Caf\u00e9 Balc\u0131, MD, Hacettepe University Faculty of Medicine Department of Internal Medicine Division of Geriatric Medicine).", "authors": [{"family": "Kananen", "given": "Laura", "initials": "L"}, {"family": "Religa", "given": "Dorota", "initials": "D"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}, {"family": "H\u00e4gg", "given": "Sara", "initials": "S"}, {"family": "Julh\u00e4v\u00e4", "given": "Juulia", "initials": "J"}, {"family": "Cederholm", "given": "Tommy", "initials": "T"}], "type": "letter", "published": "2021-12-23", "journal": {"title": "Clin Nutr", "issn": "1532-1983", "issn-l": null}, "abstract": null, "doi": "10.1016/j.clnu.2021.12.027", "pmid": "35027222", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0261-5614(21)00584-7"}, {"db": "pmc", "key": "PMC8695347"}], "notes": [], "created": "2022-01-27T08:13:47.281Z", "modified": "2022-01-27T08:13:47.286Z"}, {"entity": "publication", "iuid": "5fa87903c2a649fb95e9eba28af4b30b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5fa87903c2a649fb95e9eba28af4b30b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5fa87903c2a649fb95e9eba28af4b30b"}}, "title": "Distance Learning Effects Among Italian Children and Parents During COVID-19 Related School Lockdown.", "authors": [{"family": "Crisci", "given": "Giulia", "initials": "G"}, {"family": "Mammarella", "given": "Irene C", "initials": "IC"}, {"family": "Moscardino", "given": "Ughetta M M", "initials": "UMM"}, {"family": "Roch", "given": "Maja", "initials": "M"}, {"family": "Thorell", "given": "Lisa B", "initials": "LB"}], "type": "journal article", "published": "2021-12-23", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "782353", "issn-l": "1664-0640"}, "abstract": "Background: During the COVID-19 pandemic, both children and their parents experienced consequences related to distance learning (DL). However, positive and negative effects have varied greatly among families, and the specific factors explaining these differences in experiences are still underexplored. In this study, we examined children's executive functions (EF) and parents' psychological well-being in relation to negative and positive effects of DL on both children and their parents. Method: Participants were 637 Italian parents (92% mothers) with a child (48% male) aged between 6 and 19 years involved in DL due to school closures during the first wave of the COVID-19 pandemic. Data were collected using an online survey. We performed three fixed-order hierarchical multiple regression analyses with child age and sex, children's EF deficits, and parents' psychological well-being as independent variables, and DL-related negative effects (on the child and on the parent) and DL-related positive effects as dependent variables. Results: The results of the regression analyses showed that for negative effects of DL, younger age and greater EF deficits explained most part of the variance. Specifically, regarding negative effects on children, the most important factor was EF deficits, whereas regarding negative effects on parents, child age was the most important factor. For positive effects of DL, all variables explained only a small part of the variance. Child age was the most important factor, but EF deficits and parents' psychological well-being also had a significant impact. Conclusions: The effects of DL during school closures vary widely across families. Our findings indicate that intervention efforts need to consider background variables, child factors, as well as parent factors when supporting families with homeschooling in times of pandemic.", "doi": "10.3389/fpsyt.2021.782353", "pmid": "35002803", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8732950"}], "notes": [], "created": "2022-01-13T21:11:22.012Z", "modified": "2022-01-13T21:11:22.026Z"}, {"entity": "publication", "iuid": "f7fc256aa7c44d34ad6da0ab245d9b4e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7fc256aa7c44d34ad6da0ab245d9b4e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7fc256aa7c44d34ad6da0ab245d9b4e"}}, "title": "Androgen deprivation therapy, comorbidity, cancer stage and mortality from COVID-19 in men with prostate cancer.", "authors": [{"family": "Gedeborg", "given": "Rolf", "initials": "R", "orcid": "0000-0002-8850-7863", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/234ef51ed7854efb8bbadc3ce35bf7d9.json"}}, {"family": "Lindhagen", "given": "Lars", "initials": "L"}, {"family": "Loeb", "given": "Stacy", "initials": "S"}, {"family": "Styrke", "given": "Johan", "initials": "J"}, {"family": "Garmo", "given": "Hans", "initials": "H"}, {"family": "Stattin", "given": "P\u00e4r", "initials": "P"}], "type": "journal article", "published": "2021-12-23", "journal": {"title": "Scand J Urol", "issn": "2168-1813", "pages": "1-8", "issn-l": null}, "abstract": "Androgens facilitate entrance of the severe acute respiratory syndrome coronavirus 2 into respiratory epithelial cells, and male sex is associated with a higher risk of death from corona virus disease (COVID-19). Androgen deprivation therapy (ADT) could possibly improve COVID-19 outcomes.\n\nIn a case-control study nested in the Prostate Cancer data Base Sweden (PCBaSe) RAPID 2019, we evaluated the association between ADT and COVID-19 as registered cause of death in men with prostate cancer. Each case was matched to 50 controls by region. We used conditional logistic regression to adjust for confounders and also evaluated potential impact of residual confounding.\n\nWe identified 474 men who died from COVID-19 in March-December 2020. In crude analyses, ADT exposure was associated with an increased risk of COVID-19 death (odds ratio [OR] 5.05, 95% CI: 4.18-6.10); however, the OR was substantially attenuated after adjustment for age, comorbidity, prostate cancer characteristics at diagnosis, recent healthcare use, and indicators of advanced cancer (adjusted OR 1.25, 95% CI: 0.95-1.65). If adjustment has accounted for at least 85% of confounding, then the true effect could be no more than a 5% reduction of the odds for COVID-19 death.\n\nThe increased mortality from COVID-19 in men with prostate cancer treated with ADT was mainly related to high age, comorbidity, and more advanced prostate cancer. There was no evidence to support the hypothesis that ADT is associated with improved COVID-19 outcomes.", "doi": "10.1080/21681805.2021.2019304", "pmid": "34939533", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-03T15:35:02.365Z", "modified": "2022-01-03T15:35:42.285Z"}, {"entity": "publication", "iuid": "5a96c0779f7449aea420f70eef901728", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5a96c0779f7449aea420f70eef901728.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5a96c0779f7449aea420f70eef901728"}}, "title": "What now for Sweden and covid-19?", "authors": [{"family": "Paterlini", "given": "Marta", "initials": "M"}], "type": "journal article", "published": "2021-12-22", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "375", "pages": "n3081", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.n3081", "pmid": "34937690", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2022-01-03T15:33:31.328Z", "modified": "2022-01-03T15:33:31.344Z"}, {"entity": "publication", "iuid": "093ffa468c994870b232e6c8f9da47f6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/093ffa468c994870b232e6c8f9da47f6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/093ffa468c994870b232e6c8f9da47f6"}}, "title": "The Exposome and Immune Health in Times of the COVID-19 Pandemic.", "authors": [{"family": "Morales", "given": "Javier S", "initials": "JS"}, {"family": "Valenzuela", "given": "Pedro L", "initials": "PL", "orcid": "0000-0003-1730-3369", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0526f21ccb3c442085a7e77fd5ff49e9.json"}}, {"family": "Castillo-Garc\u00eda", "given": "Adri\u00e1n", "initials": "A"}, {"family": "Butrague\u00f1o", "given": "Javier", "initials": "J"}, {"family": "Jim\u00e9nez-Pav\u00f3n", "given": "David", "initials": "D", "orcid": "0000-0002-8977-4744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0b7642d758d4e2aa4f69df83a0c2c73.json"}}, {"family": "Carrera-Bastos", "given": "Pedro", "initials": "P"}, {"family": "Lucia", "given": "Alejandro", "initials": "A"}], "type": "journal article", "published": "2021-12-22", "journal": {"title": "Nutrients", "issn": "2072-6643", "volume": "14", "issue": "1", "issn-l": null}, "abstract": "Growing evidence supports the importance of lifestyle and environmental exposures-collectively referred to as the 'exposome'-for ensuring immune health. In this narrative review, we summarize and discuss the effects of the different exposome components (physical activity, body weight management, diet, sun exposure, stress, sleep and circadian rhythms, pollution, smoking, and gut microbiome) on immune function and inflammation, particularly in the context of the current coronavirus disease 2019 (COVID-19) pandemic. We highlight the potential role of 'exposome improvements' in the prevention-or amelioration, once established-of this disease as well as their effect on the response to vaccination. In light of the existing evidence, the promotion of a healthy exposome should be a cornerstone in the prevention and management of the COVID-19 pandemic and other eventual pandemics.", "doi": "10.3390/nu14010024", "pmid": "35010900", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "nu14010024"}], "notes": [], "created": "2022-01-13T21:07:19.748Z", "modified": "2022-01-13T21:07:21.095Z"}, {"entity": "publication", "iuid": "dd739d1768c84ea29a5623e9375eb5ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dd739d1768c84ea29a5623e9375eb5ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dd739d1768c84ea29a5623e9375eb5ca"}}, "title": "SARS-CoV-2 reactive and neutralizing antibodies discovered by single-cell sequencing of plasma cells and mammalian display.", "authors": [{"family": "Ehling", "given": "Roy A", "initials": "RA"}, {"family": "Weber", "given": "C\u00e9dric R", "initials": "CR"}, {"family": "Mason", "given": "Derek M", "initials": "DM"}, {"family": "Friedensohn", "given": "Simon", "initials": "S"}, {"family": "Wagner", "given": "Bastian", "initials": "B"}, {"family": "Bieberich", "given": "Florian", "initials": "F"}, {"family": "Kapetanovic", "given": "Edo", "initials": "E"}, {"family": "Vazquez-Lombardi", "given": "Rodrigo", "initials": "R"}, {"family": "Di Roberto", "given": "Rapha\u00ebl B", "initials": "RB"}, {"family": "Hong", "given": "Kai-Lin", "initials": "KL"}, {"family": "Wagner", "given": "Camille", "initials": "C"}, {"family": "Pataia", "given": "Michele", "initials": "M"}, {"family": "Overath", "given": "Max D", "initials": "MD"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Yermanos", "given": "Alexander", "initials": "A"}, {"family": "Cuny", "given": "Andreas P", "initials": "AP"}, {"family": "Savic", "given": "Miodrag", "initials": "M"}, {"family": "Rudolf", "given": "Fabian", "initials": "F"}, {"family": "Reddy", "given": "Sai T", "initials": "ST"}], "type": "journal article", "published": "2021-12-22", "journal": {"title": "Cell Rep", "issn": "2211-1247", "pages": "110242", "issn-l": null}, "abstract": "Characterization of COVID-19 antibodies has largely focused on memory B cells; however, it is the antibody-secreting plasma cells that are directly responsible for the production of serum antibodies, which play a critical role in resolving SARS-CoV-2 infection. Little is known about the specificity of plasma cells, largely because plasma cells lack surface antibody expression, thereby complicating their screening. Here, we describe a technology pipeline that integrates single-cell antibody repertoire sequencing and mammalian display to interrogate the specificity of plasma cells from 16 convalescent patients. Single-cell sequencing allows us to profile antibody repertoire features and identify expanded clonal lineages. Mammalian display screening is used to reveal that 43 antibodies (of 132 candidates) derived from expanded plasma cell lineages are specific to SARS-CoV-2 antigens, including antibodies with high affinity to the SARS-CoV-2 receptor-binding domain (RBD) that exhibit potent neutralization and broad binding to the RBD of SARS-CoV-2 variants (of concern/interest).", "doi": "10.1016/j.celrep.2021.110242", "pmid": "34998467", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2211-1247(21)01751-4"}, {"db": "URL", "key": "https://github.com/LSSI-ETH", "description": "https://github.com/LSSI-ETH"}, {"db": "URL", "key": "https://dx.doi.org/10.17632/rvd7999gk4.1", "description": "Fully annotated extracted antibody sequences and single cell results"}, {"db": "BioProject", "key": "http://www.ncbi.nlm.nih.gov/bioproject/782883", "description": "http://www.ncbi.nlm.nih.gov/bioproject/782883"}, {"db": "URL", "key": "http://www.ncbi.nlm.nih.gov/bioproject/782992", "description": "http://www.ncbi.nlm.nih.gov/bioproject/782992"}], "notes": [], "created": "2022-01-10T11:52:01.582Z", "modified": "2022-01-10T11:54:42.355Z"}, {"entity": "publication", "iuid": "d06ea09961354e1eb33ebe12c661c146", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d06ea09961354e1eb33ebe12c661c146.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d06ea09961354e1eb33ebe12c661c146"}}, "title": "Characteristics and outcomes of patients with COVID-19 with and without prevalent hypertension: a multinational cohort study.", "authors": [{"family": "Reyes", "given": "Carlen", "initials": "C", "orcid": "0000-0001-8486-3265", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64ac81f77bd340b0a29d97ee85d1f5c8.json"}}, {"family": "Pistillo", "given": "Andrea", "initials": "A"}, {"family": "Fern\u00e1ndez-Bertol\u00edn", "given": "Sergio", "initials": "S"}, {"family": "Recalde", "given": "Martina", "initials": "M"}, {"family": "Roel", "given": "Elena", "initials": "E"}, {"family": "Puente", "given": "Diana", "initials": "D"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Blacketer", "given": "Clair", "initials": "C"}, {"family": "Lai", "given": "Lana", "initials": "L"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Ahmed", "given": "Waheed-Ui-Rahman", "initials": "WU"}, {"family": "Alser", "given": "Osaid", "initials": "O", "orcid": "0000-0001-6743-803X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c919eb8e21f74327b80f25eae0313eb6.json"}}, {"family": "Alghoul", "given": "Heba", "initials": "H", "orcid": "0000-0001-8234-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e3deb1abdf54088a29dee7675a18697.json"}}, {"family": "Areia", "given": "Carlos", "initials": "C", "orcid": "0000-0002-4668-7069", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7232f54be5df43f0b984d0117d88a054.json"}}, {"family": "Dawoud", "given": "Dalia", "initials": "D"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A", "orcid": "0000-0003-1202-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47f086bb6ccd49a2a5f11a32c06277c8.json"}}, {"family": "Valveny", "given": "Neus", "initials": "N"}, {"family": "de Maeztu", "given": "Gabriel", "initials": "G"}, {"family": "Sorl\u00ed Red\u00f3", "given": "Luisa", "initials": "L"}, {"family": "Martinez Roldan", "given": "Jordi", "initials": "J"}, {"family": "Lopez Montesinos", "given": "Inmaculada", "initials": "I"}, {"family": "Schilling", "given": "Lisa M", "initials": "LM"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Shah", "given": "Nigam", "initials": "N"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "DuVall", "given": "Scott L", "initials": "SL"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR", "orcid": "0000-0003-0621-1979", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d03ea51cfd6344d5a6469fef31e9f941.json"}}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Kostka", "given": "Kristin", "initials": "K", "orcid": "0000-0003-2595-8736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9675cf1b775341f6a3521c7dde950262.json"}}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T", "orcid": "0000-0002-8274-0357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11fd8deb257445e7a93a0a3098b246df.json"}}], "type": "journal article", "published": "2021-12-22", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "12", "pages": "e057632", "issn-l": "2044-6055"}, "abstract": "To characterise patients with and without prevalent hypertension and COVID-19 and to assess adverse outcomes in both inpatients and outpatients.\n\nThis is a retrospective cohort study using 15 healthcare databases (primary and secondary electronic healthcare records, insurance and national claims data) from the USA, Europe and South Korea, standardised to the Observational Medical Outcomes Partnership common data model. Data were gathered from 1 March to 31 October 2020.\n\nTwo non-mutually exclusive cohorts were defined: (1) individuals diagnosed with COVID-19 (diagnosed cohort) and (2) individuals hospitalised with COVID-19 (hospitalised cohort), and stratified by hypertension status. Follow-up was from COVID-19 diagnosis/hospitalisation to death, end of the study period or 30 days.\n\nDemographics, comorbidities and 30-day outcomes (hospitalisation and death for the 'diagnosed' cohort and adverse events and death for the 'hospitalised' cohort) were reported.\n\nWe identified 2 851 035 diagnosed and 563 708 hospitalised patients with COVID-19. Hypertension was more prevalent in the latter (ranging across databases from 17.4% (95% CI 17.2 to 17.6) to 61.4% (95% CI 61.0 to 61.8) and from 25.6% (95% CI 24.6 to 26.6) to 85.9% (95% CI 85.2 to 86.6)). Patients in both cohorts with hypertension were predominantly >50 years old and female. Patients with hypertension were frequently diagnosed with obesity, heart disease, dyslipidaemia and diabetes. Compared with patients without hypertension, patients with hypertension in the COVID-19 diagnosed cohort had more hospitalisations (ranging from 1.3% (95% CI 0.4 to 2.2) to 41.1% (95% CI 39.5 to 42.7) vs from 1.4% (95% CI 0.9 to 1.9) to 15.9% (95% CI 14.9 to 16.9)) and increased mortality (ranging from 0.3% (95% CI 0.1 to 0.5) to 18.5% (95% CI 15.7 to 21.3) vs from 0.2% (95% CI 0.2 to 0.2) to 11.8% (95% CI 10.8 to 12.8)). Patients in the COVID-19 hospitalised cohort with hypertension were more likely to have acute respiratory distress syndrome (ranging from 0.1% (95% CI 0.0 to 0.2) to 65.6% (95% CI 62.5 to 68.7) vs from 0.1% (95% CI 0.0 to 0.2) to 54.7% (95% CI 50.5 to 58.9)), arrhythmia (ranging from 0.5% (95% CI 0.3 to 0.7) to 45.8% (95% CI 42.6 to 49.0) vs from 0.4% (95% CI 0.3 to 0.5) to 36.8% (95% CI 32.7 to 40.9)) and increased mortality (ranging from 1.8% (95% CI 0.4 to 3.2) to 25.1% (95% CI 23.0 to 27.2) vs from 0.7% (95% CI 0.5 to 0.9) to 10.9% (95% CI 10.4 to 11.4)) than patients without hypertension.\n\nCOVID-19 patients with hypertension were more likely to suffer severe outcomes, hospitalisations and deaths compared with those without hypertension.", "doi": "10.1136/bmjopen-2021-057632", "pmid": "34937726", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-057632"}, {"db": "pmc", "key": "PMC8704062"}], "notes": [], "created": "2022-01-03T15:34:18.912Z", "modified": "2022-01-03T15:34:32.723Z"}, {"entity": "publication", "iuid": "87c62cac7b124fa7a08738b66eae598f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87c62cac7b124fa7a08738b66eae598f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87c62cac7b124fa7a08738b66eae598f"}}, "title": "Plasma Leptin Is Increased in Intensive Care Patients with COVID-19-An Investigation Performed in the PronMed-Cohort.", "authors": [{"family": "Larsson", "given": "Anders", "initials": "A", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2be858ab604743b72383dfdcd14689.json"}}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Eriksson", "given": "Mats", "initials": "M", "orcid": "0000-0002-3178-4210", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c90375295094966a51f9d17c275abb6.json"}}], "type": "journal article", "published": "2021-12-21", "journal": {"title": "Biomedicines", "issn": "2227-9059", "issn-l": null, "volume": "10", "issue": "1", "pages": null}, "abstract": "COVID-19 has shaken the world and intensive care units (ICU) have been challenged by numerous patients suffering from a previously unknown disease. Leptin is a polypeptide pleiotropic hormone, mainly expressed by adipocytes. It acts as a proinflammatory cytokine and is associated with several conditions, known to increase the risk of severe COVID-19. Very little is known about leptin in severe viral disorders. Plasma leptin was analyzed in 222 out of 229 patients with severe COVID-19 on admission to an ICU at Uppsala University Hospital, a tertiary care hospital in Sweden, and compared to plasma leptin in 25 healthy blood donors. COVID-19 was confirmed by positive PCR. Leptin levels were significantly higher in patients with COVID-19 (18.3 ng \u00d7 mL-1; IQR = 30.4), than in healthy controls (7.8 ng \u00d7 mL-1; IQR = 6.4). Women had significantly higher leptin values (22.9 ng \u00d7 mL-1; IQR = 29.8) than men (17.5 ng \u00d7 mL-1; IQR = 29.9). Mortality at 30 days was 23% but was not associated with increased leptin levels. Neither median duration of COVID-19 before admission to ICU (10 days; IQR = 4) or median length of ICU stay (8 days; IQR = 11) correlated with the plasma leptin levels. Leptin levels in COVID-19 were higher in females than in males. Both treatment (e.g., use of corticosteroids) and prophylaxis (vaccines) have been improved since the start of the COVID-19 pandemic, which may contribute to some difficulties in deciphering relations between COVID-19 and leptin.", "doi": "10.3390/biomedicines10010004", "pmid": "35052684", "labels": {"Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Biochemistry": null, "Funder: VR": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "biomedicines10010004"}], "notes": [], "created": "2022-01-26T10:22:24.166Z", "modified": "2022-02-08T19:22:23.653Z"}, {"entity": "publication", "iuid": "ef350c9ac7a04e84bc75cd86b285cc1e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef350c9ac7a04e84bc75cd86b285cc1e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef350c9ac7a04e84bc75cd86b285cc1e"}}, "title": "Considerations for COVID-19 management in reception centers for refugees, asylum seekers and migrants, Spain 2020.", "authors": [{"family": "Hoefer", "given": "Andreas", "initials": "A"}, {"family": "Pampaka", "given": "Despina", "initials": "D"}, {"family": "Castrillejo", "given": "Daniel", "initials": "D"}, {"family": "Luenga-Cabrera", "given": "Jos\u00e9", "initials": "J"}, {"family": "Paisi", "given": "Martha", "initials": "M"}, {"family": "Herrera-Le\u00f3n", "given": "Silvia", "initials": "S"}, {"family": "L\u00f3pez-Perea", "given": "Noem\u00ed", "initials": "N"}, {"family": "Del Diego-Salas", "given": "Jorge", "initials": "J"}], "type": "journal article", "published": "2021-12-21", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": null, "issue": null, "pages": null}, "abstract": "Shortly after the declaration of the COVID-19 pandemic, governments around the world were urged to leave no population behind. Following a COVID-19 risk evaluation in a refugee and asylum seekers reception center, in September 2020, we considered the priorities of managing COVID-19 in these settings. We encourage actions on four fronts to reduce the COVID-19 associated burden amongst these vulnerable populations based on our interviews, observations and recommendations: (i) decongestion, (ii) facilitated testing, (iii) screening for symptoms and (iv) targeted public health and risk communication.", "doi": "10.1016/j.ijid.2021.12.341", "pmid": "34952212", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)01240-6"}, {"db": "pmc", "key": "PMC8690219"}], "notes": [], "created": "2022-01-04T15:26:01.536Z", "modified": "2022-11-22T05:43:02.433Z"}, {"entity": "publication", "iuid": "1366fc55cc6947d495356d3d29942458", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1366fc55cc6947d495356d3d29942458.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1366fc55cc6947d495356d3d29942458"}}, "title": "Chaplain Leadership During COVID-19: An International Expert Panel.", "authors": [{"family": "Szilagyi", "given": "Csaba", "initials": "C", "orcid": "0000-0002-0413-3025", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d833cb5acf3f432395c8b03de5554f81.json"}}, {"family": "Vandenhoeck", "given": "Anne", "initials": "A", "orcid": "0000-0003-0479-6408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d02323e639d4c38acbe70795fe2f6db.json"}}, {"family": "Best", "given": "Megan C", "initials": "MC"}, {"family": "Desjardins", "given": "Cate Michelle", "initials": "CM", "orcid": "0000-0002-7928-3239", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c98b6cd4026249cdaffd63d17cf0d302.json"}}, {"family": "Drummond", "given": "David A", "initials": "DA"}, {"family": "Fitchett", "given": "George", "initials": "G"}, {"family": "Harrison", "given": "Simon", "initials": "S"}, {"family": "Haythorn", "given": "Trace", "initials": "T", "orcid": "0000-0001-7681-6522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/018d1123ea7c4a5e9b4886eb4a1052ab.json"}}, {"family": "Holmes", "given": "Cheryl", "initials": "C"}, {"family": "Muthert", "given": "Hanneke", "initials": "H", "orcid": "0000-0002-1975-6102", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2442aa919afa40669626e7f91ae961d8.json"}}, {"family": "Nuzum", "given": "Daniel", "initials": "D", "orcid": "0000-0002-9907-5680", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ef033373aa741dfab63209ec5238ff9.json"}}, {"family": "Verhoef", "given": "Joost H A", "initials": "JHA"}, {"family": "Willander", "given": "Erika", "initials": "E"}], "type": "journal article", "published": "2021-12-21", "journal": {"title": "J Pastoral Care Counsel", "issn": "2167-776X", "pages": "15423050211067724", "issn-l": null}, "abstract": "Chaplain leadership may have played a pivotal role in shaping chaplains' roles in health care amidst the COVID-19 pandemic. We convened an international expert panel to identify expert perception on key chaplain leadership factors. Six leadership themes of professional confidence, engaging and trust-building with executives, decision-making, innovation and creativity, building integrative and trusting connections with colleagues, and promoting cultural competencies emerged as central to determining chaplains' integration, perceived value, and contributions during the pandemic.", "doi": "10.1177/15423050211067724", "pmid": "34931932", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-03T15:30:43.220Z", "modified": "2022-01-03T15:30:43.448Z"}, {"entity": "publication", "iuid": "9bec6670580f4b5ebfa595be1ce83f4a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9bec6670580f4b5ebfa595be1ce83f4a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9bec6670580f4b5ebfa595be1ce83f4a"}}, "title": "The COVID-19 pandemic as experienced by adults with congenital heart disease from Belgium, Norway, and South Korea: impact on life domains, patient-reported outcomes, and experiences with care.", "authors": [{"family": "Moons", "given": "Philip", "initials": "P", "orcid": "0000-0002-8609-4516", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c7081af91424589a389e04745224849.json"}}, {"family": "Goossens", "given": "Eva", "initials": "E", "orcid": "0000-0003-3421-5256", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3869f53db0f542ac9c1ddf2a2527d2dc.json"}}, {"family": "Luyckx", "given": "Koen", "initials": "K", "orcid": "0000-0001-8862-5598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/794e7a8d0d2f4ead85fffcb95e054be4.json"}}, {"family": "Kovacs", "given": "Adrienne H", "initials": "AH", "orcid": "0000-0002-2687-0384", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/efc671a612194680a5db5e0bf04cf1d9.json"}}, {"family": "Andresen", "given": "Brith", "initials": "B", "orcid": "0000-0003-4359-9757", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/127245033cae4fc59d8eaeb693b52064.json"}}, {"family": "Moon", "given": "Ju Ryoung", "initials": "JR", "orcid": "0000-0002-4285-0295", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f415f05186a4935bc3ddc3de52059f9.json"}}, {"family": "Van De Bruaene", "given": "Alexander", "initials": "A", "orcid": "0000-0002-0469-8640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/603e48f2c9284953a674b3bae0392d1d.json"}}, {"family": "Rassart", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8535-1499", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d560e6e869849f6a9a8b23cb6765795.json"}}, {"family": "Van Bulck", "given": "Liesbet", "initials": "L", "orcid": "0000-0001-8975-4455", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bfadcaac546b4a818af2651cef4d0973.json"}}, {"family": "APPROACH-IS II consortium and ISACHD\n", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-20", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "issn-l": null}, "abstract": "The coronavirus disease-2019 (COVID-19) pandemic poses significant challenges to many groups within societies, and especially for people with chronic health conditions. It is, however, unknown whether and how the pandemic has thus far affected the physical and mental health of patient populations. Therefore, we investigated how the pandemic affected the lives of adults with congenital heart disease (CHD), compared pre- and peri-pandemic patient-reported outcome measures (PROMs) and a patient-reported experience measure (PREM), and investigated whether having had COVID-19 impacted pre-/peri-pandemic differences of the PROMs and PREM.\n\nAs part of the ongoing APPROACH-IS II project, we longitudinally surveyed 716 adults with CHD from Belgium, Norway, and South Korea. Pre-pandemic measures were administered from August 2019 to February 2020 and the peri-pandemic surveys were completed September 2020-April 2021. The majority of patients indicated that their social lives (80%), mental health (58%), and professional lives/education (51%) were negatively impacted by the pandemic. Patients felt worried (65%), were afraid (55%), reported the pandemic felt 'close' to them (53%), and were stressed (52%). However, differences between pre- and peri-pandemic scores on the PROMs and PREM were negligibly small (Cohen's d < 0.20). Across measures, 5.8-15.8% of patients demonstrated changes (improved or worsened scores) that exceeded the minimal clinically important difference. There were no difference-in-differences for PROMs and PREM between patients who did vs. did not have COVID-19.\n\nAlthough the COVID-19 pandemic has been disruptive in many ways, pre- to peri-pandemic changes in PROMs and PREM of adults with CHD were negligibly small.", "doi": "10.1093/eurjcn/zvab120", "pmid": "34927192", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6470369"}], "notes": [], "created": "2022-01-03T15:26:00.354Z", "modified": "2022-01-03T15:26:00.655Z"}, {"entity": "publication", "iuid": "741cface6f554bdfb3637d2cb1c2f4c7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/741cface6f554bdfb3637d2cb1c2f4c7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/741cface6f554bdfb3637d2cb1c2f4c7"}}, "title": "Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor.", "authors": [{"family": "Capraz", "given": "T\u00fcmay", "initials": "T", "orcid": "0000-0002-2547-067X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/16b4b4685c774fa394868d772e33e1a0.json"}}, {"family": "Kienzl", "given": "Nikolaus F", "initials": "NF", "orcid": "0000-0001-8057-3930", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00ccebd4f3c34f38b227a2ad414f9dfb.json"}}, {"family": "Laurent", "given": "Elisabeth", "initials": "E", "orcid": "0000-0002-5234-5524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a18c078a3654424b48790ac3409a684.json"}}, {"family": "Perthold", "given": "Jan W", "initials": "JW", "orcid": "0000-0002-8575-0278", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a40db3855af4c39ae1958e99072117a.json"}}, {"family": "F\u00f6derl-H\u00f6benreich", "given": "Esther", "initials": "E", "orcid": "0000-0003-2066-1036", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a769b59ed6e74abca396b6bb69461548.json"}}, {"family": "Gr\u00fcnwald-Gruber", "given": "Clemens", "initials": "C", "orcid": "0000-0002-6097-8348", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/065d1d48a41b4bd6ae83d28277037bea.json"}}, {"family": "Maresch", "given": "Daniel", "initials": "D"}, {"family": "Monteil", "given": "Vanessa", "initials": "V", "orcid": "0000-0002-2652-5695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8ba8a0b1af6423b9cba0fc4bb3177cd.json"}}, {"family": "Niederh\u00f6fer", "given": "Janine", "initials": "J"}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G", "orcid": "0000-0001-7035-7038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70afca1611904e419eca43bde2d681be.json"}}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Zatloukal", "given": "Kurt", "initials": "K", "orcid": "0000-0001-5299-7218", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6a34a836db947d0a327f197a5f938fb.json"}}, {"family": "Mach", "given": "Lukas", "initials": "L", "orcid": "0000-0001-9013-5408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e58ab479be1e4abd9f95f0c5737f280b.json"}}, {"family": "Penninger", "given": "Josef M", "initials": "JM", "orcid": "0000-0002-8194-3777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e56aaa008524272bf252df804e06991.json"}}, {"family": "Oostenbrink", "given": "Chris", "initials": "C", "orcid": "0000-0002-4232-2556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37566a0341cf4fd38366e43218cffd23.json"}}, {"family": "Stadlmann", "given": "Johannes", "initials": "J", "orcid": "0000-0001-5693-6690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab12a13b3ddd442588c1c9bda683d9ee.json"}}], "type": "journal article", "published": "2021-12-20", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "10", "issn-l": null}, "abstract": "Infection and viral entry of SARS-CoV-2 crucially depends on the binding of its Spike protein to angiotensin converting enzyme 2 (ACE2) presented on host cells. Glycosylation of both proteins is critical for this interaction. Recombinant soluble human ACE2 can neutralize SARS-CoV-2 and is currently undergoing clinical tests for the treatment of COVID-19. We used 3D structural models and molecular dynamics simulations to define the ACE2 N-glycans that critically influence Spike-ACE2 complex formation. Engineering of ACE2 N-glycosylation by site-directed mutagenesis or glycosidase treatment resulted in enhanced binding affinities and improved virus neutralization without notable deleterious effects on the structural stability and catalytic activity of the protein. Importantly, simultaneous removal of all accessible N-glycans from recombinant soluble human ACE2 yields a superior SARS-CoV-2 decoy receptor with promise as effective treatment for COVID-19 patients.", "doi": "10.7554/eLife.73641", "pmid": "34927585", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8730730"}, {"db": "pii", "key": "73641"}], "notes": [], "created": "2022-01-03T15:26:30.313Z", "modified": "2023-06-19T14:37:25.873Z"}, {"entity": "publication", "iuid": "b5b248ae72da40448398da21a0a9cf85", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5b248ae72da40448398da21a0a9cf85.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5b248ae72da40448398da21a0a9cf85"}}, "title": "Immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in older residents of a long-term care facility: relation with age, frailty and prior infection status.", "authors": [{"family": "Seiffert", "given": "Piotr", "initials": "P", "orcid": "0000-0001-7987-5640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3350920951f422eac0c2667c7aae4c9.json"}}, {"family": "Konka", "given": "Adam", "initials": "A"}, {"family": "Kasperczyk", "given": "Janusz", "initials": "J", "orcid": "0000-0002-6945-1200", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f0d95aa2fe1446bafb2ed67696b4146.json"}}, {"family": "Kawa", "given": "Jacek", "initials": "J", "orcid": "0000-0002-2804-7885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4126c74290704df495c610f0b5646d97.json"}}, {"family": "Lejawa", "given": "Mateusz", "initials": "M", "orcid": "0000-0002-1228-7534", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e36f837cd6054b2592d7b7d5dbd57a03.json"}}, {"family": "Ma\u015blanka-Seiffert", "given": "Barbara", "initials": "B", "orcid": "0000-0002-5524-0760", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2529abd1474e49d295c477ffeb767c36.json"}}, {"family": "Zembala-John", "given": "Joanna", "initials": "J", "orcid": "0000-0001-5787-3820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91acb29e031941d6b33a968d7e57cb3e.json"}}, {"family": "Bugdol", "given": "Monika", "initials": "M", "orcid": "0000-0002-6917-0441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/38995f1aae584d2182028ef11a89da3a.json"}}, {"family": "Romanik", "given": "Ma\u0142gorzata", "initials": "M", "orcid": "0000-0003-0377-9833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a748240d8bd48b5a126909ab565022d.json"}}, {"family": "Bu\u0142dak", "given": "Rafa\u0142", "initials": "R", "orcid": "0000-0002-0405-0596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44aad3c48a484fd1bf10681a361b795d.json"}}, {"family": "Marcisz", "given": "Czes\u0142aw", "initials": "C", "orcid": "0000-0001-9313-1007", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed63975fc6ca41e89b876d4df2408df3.json"}}, {"family": "Derejczyk", "given": "Jaros\u0142aw", "initials": "J"}, {"family": "Religa", "given": "Dorota", "initials": "D", "orcid": "0000-0003-4583-4570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e2c968ecffa4c638126d6d8d4a0dbd9.json"}}], "type": "journal article", "published": "2021-12-19", "journal": {"title": "Biogerontology", "issn": "1573-6768", "issn-l": null}, "abstract": "Clinical and biological assessment of the COVID-19 vaccine efficacy in the frail population is of crucial importance. The study focuses on measuring the levels of anti-SARS-CoV-2 IgG antibodies before and after BNT162b2 mRNA COVID-19 vaccination among long-term care facility (LTCF) elderly residents. We conducted a prospective, single-center, observational study among LTCF residents. The study protocol was based on three blood sample acquisitions: first taken at baseline-5 days before the first dose of the vaccine, second-20 days after the first dose, and third-12 days after the second shot of the vaccine. The comparison was made for two cohorts: patients with and without prior COVID-19 infection. The data was collected from January to March 2021. A total number of 78 LTCF residents (55 women and 23 men) aged 62-104, 85.72 \u00b1 7.59 years (mean \u00b1 SD), were enrolled in the study. All study participants were investigated for the presence of SARS-CoV-2 anti-spike (S) protein IgG, using a chemiluminescent immunoassay. Frailty was assessed with the Clinical Frailty Scale. Among elderly COVID-19 survivors in LTCF, a single dose of vaccine significantly increased anti-SARS-CoV-2 IgG antibody levels. IgG concentration after a single and double dose was comparable, which may suggest that elderly COVID-19 survivors do not require a second dose of vaccine. For residents without a previous history of COVID-19, two doses are needed to achieve an effective serological response. The level of anti-SARS-CoV-2 IgG antibodies after vaccination with BNT162b2 mRNA COVID-19 did not correlate with the frailty and age of the studied individuals.", "doi": "10.1007/s10522-021-09944-9", "pmid": "34923608", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10522-021-09944-9"}], "notes": [], "created": "2021-12-20T08:32:52.960Z", "modified": "2021-12-20T08:32:53.315Z"}, {"entity": "publication", "iuid": "625ae786f98c4461aea160f935df1fb6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/625ae786f98c4461aea160f935df1fb6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/625ae786f98c4461aea160f935df1fb6"}}, "title": "The impact of COVID-19 on oncology professionals-one year on: lessons learned from the ESMO Resilience Task Force survey series.", "authors": [{"family": "Lim", "given": "K H J", "initials": "KHJ"}, {"family": "Murali", "given": "K", "initials": "K"}, {"family": "Thorne", "given": "E", "initials": "E"}, {"family": "Punie", "given": "K", "initials": "K"}, {"family": "Kamposioras", "given": "K", "initials": "K"}, {"family": "Oing", "given": "C", "initials": "C"}, {"family": "O'Connor", "given": "M", "initials": "M"}, {"family": "\u00c9lez", "given": "E", "initials": "E"}, {"family": "Amaral", "given": "T", "initials": "T"}, {"family": "Garrido", "given": "P", "initials": "P"}, {"family": "Lambertini", "given": "M", "initials": "M"}, {"family": "Devnani", "given": "B", "initials": "B"}, {"family": "Westphalen", "given": "C B", "initials": "CB"}, {"family": "Morgan", "given": "G", "initials": "G"}, {"family": "Haanen", "given": "J B A G", "initials": "JBAG"}, {"family": "Hardy", "given": "C", "initials": "C"}, {"family": "Banerjee", "given": "S", "initials": "S"}], "type": "journal article", "published": "2021-12-17", "journal": {"title": "ESMO Open", "issn": "2059-7029", "volume": "7", "issue": "1", "pages": "100374", "issn-l": null}, "abstract": "COVID-19 has had a significant impact on the well-being and job performance of oncology professionals globally. The European Society for Medical Oncology (ESMO) Resilience Task Force collaboration set out to investigate and monitor well-being since COVID-19 in relation to work, lifestyle and support factors in oncology professionals 1 year on since the start of the pandemic.\n\nAn online, anonymous survey was conducted in February/March 2021 (Survey III). Key outcome variables included risk of poor well-being or distress (expanded Well-Being Index), feeling burnout (single item from expanded Well-Being Index), and job performance since COVID-19. Longitudinal analysis of responses to the series of three surveys since COVID-19 was carried out, and responses to job demands and resources questions were interrogated. SPSS V.26.0/V.27.0 and GraphPad Prism V9.0 were used for statistical analyses.\n\nResponses from 1269 participants from 104 countries were analysed in Survey III: 55% (n = 699/1269) female, 54% (n = 686/1269) >40 years, and 69% (n = 852/1230) of white ethnicity. There continues to be an increased risk of poor well-being or distress (n = 464/1169, 40%) and feeling burnout (n = 660/1169, 57%) compared with Survey I (25% and 38% respectively, P < 0.0001), despite improved job performance. Compared with the initial period of the pandemic, more participants report feeling overwhelmed with workload (45% versus 29%, P < 0.0001). There remain concerns about the negative impact of the pandemic on career development/training (43%), job security (37%). and international fellowship opportunities (76%). Alarmingly, 25% (n = 266/1086) are considering changing their future career with 38% (n = 100/266) contemplating leaving the profession.\n\nOncology professionals continue to face increased job demands. There is now significant concern regarding potential attrition in the oncology workforce. National and international stakeholders must act immediately and work closely with oncology professionals to draw up future-proof recovery plans.", "doi": "10.1016/j.esmoop.2021.100374", "pmid": "35007996", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2059-7029(21)00336-7"}, {"db": "pmc", "key": "PMC8677468"}], "notes": [], "created": "2022-01-13T21:09:07.089Z", "modified": "2022-01-13T21:09:07.104Z"}, {"entity": "publication", "iuid": "fe20006bef944898a5ba6fb7a08430f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fe20006bef944898a5ba6fb7a08430f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fe20006bef944898a5ba6fb7a08430f8"}}, "title": "Predicting regional COVID-19 hospital admissions in Sweden using mobility data.", "authors": [{"family": "Gerlee", "given": "Philip", "initials": "P", "orcid": "0000-0001-8503-0177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ba426c1ab741e781d2b9cd09a0b830.json"}}, {"family": "Karlsson", "given": "Julia", "initials": "J"}, {"family": "Fritzell", "given": "Ingrid", "initials": "I"}, {"family": "Brezicka", "given": "Thomas", "initials": "T"}, {"family": "Spreco", "given": "Armin", "initials": "A"}, {"family": "Timpka", "given": "Toomas", "initials": "T"}, {"family": "J\u00f6ud", "given": "Anna", "initials": "A", "orcid": "0000-0001-7192-4911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e038a5ce2f5a47bd89e7c221651a3d24.json"}}, {"family": "Lundh", "given": "Torbj\u00f6rn", "initials": "T"}], "type": "journal article", "published": "2021-12-17", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "24171", "issn-l": "2045-2322"}, "abstract": "The transmission of COVID-19 is dependent on social mixing, the basic rate of which varies with sociodemographic, cultural, and geographic factors. Alterations in social mixing and subsequent changes in transmission dynamics eventually affect hospital admissions. We employ these observations to model and predict regional hospital admissions in Sweden during the COVID-19 pandemic. We use an SEIR-model for each region in Sweden in which the social mixing is assumed to depend on mobility data from public transport utilisation and locations for mobile phone usage. The results show that the model could capture the timing of the first and beginning of the second wave of the pandemic 3 weeks in advance without any additional assumptions about seasonality. Further, we show that for two major regions of Sweden, models with public transport data outperform models using mobile phone usage. We conclude that a model based on routinely collected mobility data makes it possible to predict future hospital admissions for COVID-19 3 weeks in advance.", "doi": "10.1038/s41598-021-03499-y", "pmid": "34921175", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8683437"}, {"db": "pii", "key": "10.1038/s41598-021-03499-y"}], "notes": [], "created": "2021-12-20T08:33:34.441Z", "modified": "2023-06-19T14:58:56.449Z"}, {"entity": "publication", "iuid": "c1d3881f25114bf690e10d021c077a59", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1d3881f25114bf690e10d021c077a59.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1d3881f25114bf690e10d021c077a59"}}, "title": "Potential SARS-CoV-2 infectiousness among asymptomatic healthcare workers.", "authors": [{"family": "Pimenoff", "given": "Ville N", "initials": "VN", "orcid": "0000-0002-0813-7031", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6df74f265514d7b8fa216d9bad0ead6.json"}}, {"family": "Elfstr\u00f6m", "given": "Miriam", "initials": "M"}, {"family": "Conneryd Lundgren", "given": "Kalle", "initials": "K"}, {"family": "Klevebro", "given": "Susanna", "initials": "S", "orcid": "0000-0002-1261-6502", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e192d615f8648c0ae28b5ccaf1d6803.json"}}, {"family": "Melen", "given": "Erik", "initials": "E"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}], "type": "journal article", "published": "2021-12-17", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "12", "pages": "e0260453", "issn-l": "1932-6203"}, "abstract": "A majority of SARS-CoV-2 infections are transmitted from a minority of infected subjects, some of which may be symptomatic or pre-symptomatic. We aimed to quantify potential infectiousness among asymptomatic healthcare workers (HCWs) in relation to prior or later symptomatic disease. We previously (at the onset of the SARS-CoV-2 epidemic) performed a cohort study of SARS-CoV-2 infections among 27,000 healthcare workers (HCWs) at work in the capital region of Sweden. We performed both SARS-CoV-2 RT-PCR and serology. Furthermore, the cohort was comprehensively followed for sick leave, both before and after sampling. In the present report, we used the cohort database to quantify potential infectiousness among HCWs at work. Those who had sick leave either before or after sampling were classified as post-symptomatic or pre-symptomatic, whereas the virus-positive subjects with no sick leave were considered asymptomatic. About 0.2% (19/9449) of HCW at work were potentially infectious and pre-symptomatic (later had disease) and 0.17% (16/9449) were potentially infectious and asymptomatic (never had sick leave either before nor after sampling). Thus, 33% and 28% of all the 57 potentially infectious subjects were pre-symptomatic or asymptomatic, respectively. When a questionnaire was administered to HCWs with past infection, only 10,5% of HCWs had had no indication at all of having had SARS-CoV-2 infection (\"truly asymptomatic\"). Our findings provide a unique quantification of the different groups of asymptomatic, potentially infectious HCWs.", "doi": "10.1371/journal.pone.0260453", "pmid": "34919570", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-25144"}, {"db": "URL", "key": "https://doi.org/10.1371/journal.pone.0260453.s001", "description": "https://doi.org/10.1371/journal.pone.0260453.s001"}], "notes": [], "created": "2021-12-18T17:37:11.654Z", "modified": "2021-12-18T17:40:54.884Z"}, {"entity": "publication", "iuid": "92fce9aeea0f4e6d8dde3d2c05f4f4f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/92fce9aeea0f4e6d8dde3d2c05f4f4f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/92fce9aeea0f4e6d8dde3d2c05f4f4f2"}}, "title": "Nuclear receptors: from molecular mechanisms to therapeutics.", "authors": [{"family": "Frigo", "given": "Daniel E", "initials": "DE", "orcid": "0000-0002-0713-471X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9838d42de57e4631b568c08cb22415cb.json"}}, {"family": "Bondesson", "given": "Maria", "initials": "M"}, {"family": "Williams", "given": "Cecilia", "initials": "C"}], "type": "editorial", "published": "2021-12-17", "journal": {"title": "Essays Biochem", "issn": "1744-1358", "volume": "65", "issue": "6", "pages": "847-856", "issn-l": null}, "abstract": "Nuclear receptors are classically defined as ligand-activated transcription factors that regulate key functions in reproduction, development, and physiology. Humans have 48 nuclear receptors, which when dysregulated are often linked to diseases. Because most nuclear receptors can be selectively activated or inactivated by small molecules, they are prominent therapeutic targets. The basic understanding of this family of transcription factors was accelerated in the 1980s upon the cloning of the first hormone receptors. During the next 20 years, a deep understanding of hormone signaling was achieved that has translated to numerous clinical applications, such as the development of standard-of-care endocrine therapies for hormonally driven breast and prostate cancers. A 2004 issue of this journal reviewed progress on elucidating the structures of nuclear receptors and their mechanisms of action. In the current issue, we focus on the broad application of new knowledge in this field for therapy across diverse disease states including cancer, cardiovascular disease, various inflammatory diseases, the aging brain, and COVID-19.", "doi": "10.1042/EBC20210020", "pmid": "34825698", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "230306"}, {"db": "pmc", "key": "PMC8628184"}], "notes": [], "created": "2021-12-18T18:18:28.799Z", "modified": "2021-12-18T18:18:28.866Z"}, {"entity": "publication", "iuid": "5c11ae1352184b6f8745bef1b04f1249", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c11ae1352184b6f8745bef1b04f1249.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c11ae1352184b6f8745bef1b04f1249"}}, "title": "Fluvastatin mitigates SARS-CoV-2 infection in human lung cells.", "authors": [{"family": "Zapatero-Belinch\u00f3n", "given": "Francisco J", "initials": "FJ"}, {"family": "Moeller", "given": "Rebecca", "initials": "R"}, {"family": "Lasswitz", "given": "Lisa", "initials": "L"}, {"family": "van Ham", "given": "Marco", "initials": "M"}, {"family": "Becker", "given": "Miriam", "initials": "M"}, {"family": "Brogden", "given": "Graham", "initials": "G"}, {"family": "Rosendal", "given": "Ebba", "initials": "E"}, {"family": "Bi", "given": "Wenjie", "initials": "W"}, {"family": "Carriqu\u00ed-Madro\u00f1al", "given": "Bel\u00e9n", "initials": "B"}, {"family": "Islam", "given": "Koushikul", "initials": "K"}, {"family": "Lenman", "given": "Annasara", "initials": "A"}, {"family": "Gunesch", "given": "Antonia P", "initials": "AP"}, {"family": "Kirui", "given": "Jared", "initials": "J"}, {"family": "Pietschmann", "given": "Thomas", "initials": "T"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "J\u00e4nsch", "given": "Lothar", "initials": "L"}, {"family": "Gerold", "given": "Gisa", "initials": "G"}], "type": "journal article", "published": "2021-12-17", "journal": {"title": "iScience", "issn": "2589-0042", "issn-l": "2589-0042", "volume": "24", "issue": "12", "pages": "103469"}, "abstract": "Clinical data of patients suffering from COVID-19 indicates that statin therapy, used to treat hypercholesterolemia, is associated with a better disease outcome. Whether statins directly affect virus replication or influence the clinical outcome through modulation of immune responses is unknown. We therefore investigated the effect of statins on SARS-CoV-2 infection in human lung cells and found that only fluvastatin inhibited low and high pathogenic coronaviruses in vitro and ex vivo in a dose-dependent manner. Quantitative proteomics revealed that fluvastatin and other tested statins modulated the cholesterol synthesis pathway without altering innate antiviral immune responses in infected lung epithelial cells. However, fluvastatin treatment specifically downregulated proteins that modulate protein translation and viral replication. Collectively, these results support the notion that statin therapy poses no additional risk to individuals exposed to SARS-CoV-2 and that fluvastatin has a moderate beneficial effect on SARS-CoV-2 infection of human lung cells.", "doi": "10.1016/j.isci.2021.103469", "pmid": "34812415", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(21)01440-1"}, {"db": "pmc", "key": "PMC8599137"}], "notes": [], "created": "2021-11-26T13:23:20.647Z", "modified": "2022-02-08T19:22:50.309Z"}, {"entity": "publication", "iuid": "4eceb96b17c1499e9310bdcc0f425bc2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4eceb96b17c1499e9310bdcc0f425bc2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4eceb96b17c1499e9310bdcc0f425bc2"}}, "title": "Differential Effect of SARS-CoV-2 Spike Glycoprotein 1 on Human Bronchial and Alveolar Lung Mucosa Models: Implications for Pathogenicity.", "authors": [{"family": "Rahman", "given": "Mizanur", "initials": "M"}, {"family": "Irmler", "given": "Martin", "initials": "M"}, {"family": "Keshavan", "given": "Sandeep", "initials": "S", "orcid": "0000-0002-2403-4083", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ada27ca05f7448838ea73da4e78220a6.json"}}, {"family": "Introna", "given": "Micol", "initials": "M", "orcid": "0000-0002-5564-1994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f3b999bbb7a4a19969f3ee84273091a.json"}}, {"family": "Beckers", "given": "Johannes", "initials": "J", "orcid": "0000-0002-1038-7160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9add2aa14db44646a7be17d450c14da0.json"}}, {"family": "Palmberg", "given": "Lena", "initials": "L"}, {"family": "Johanson", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8759-9567", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb124bc8baaf4bf8a811a2ffa0abdf0d.json"}}, {"family": "Ganguly", "given": "Koustav", "initials": "K", "orcid": "0000-0001-8531-8154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58b2e0d7853a4b32920e54042e95061d.json"}}, {"family": "Upadhyay", "given": "Swapna", "initials": "S"}], "type": "journal article", "published": "2021-12-17", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "13", "issue": "12", "pages": null}, "abstract": "The SARS-CoV-2 spike protein mediates attachment of the virus to the host cell receptor and fusion between the virus and the cell membrane. The S1 subunit of the spike glycoprotein (S1 protein) contains the angiotensin converting enzyme 2 (ACE2) receptor binding domain. The SARS-CoV-2 variants of concern contain mutations in the S1 subunit. The spike protein is the primary target of neutralizing antibodies generated following infection, and constitutes the viral component of mRNA-based COVID-19 vaccines.\r\n\r\nTherefore, in this work we assessed the effect of exposure (24 h) to 10 nM SARS-CoV-2 recombinant S1 protein on physiologically relevant human bronchial (bro) and alveolar (alv) lung mucosa models cultured at air-liquid interface (ALI) (n = 6 per exposure condition). Corresponding sham exposed samples served as a control. The bro-ALI model was developed using primary bronchial epithelial cells and the alv-ALI model using representative type II pneumocytes (NCI-H441).\r\n\r\nExposure to S1 protein induced the surface expression of ACE2, toll like receptor (TLR) 2, and TLR4 in both bro-ALI and alv-ALI models. Transcript expression analysis identified 117 (bro-ALI) and 97 (alv-ALI) differentially regulated genes (p \u2264 0.01). Pathway analysis revealed enrichment of canonical pathways such as interferon (IFN) signaling, influenza, coronavirus, and anti-viral response in the bro-ALI. Secreted levels of interleukin (IL) 4 and IL12 were significantly (p < 0.05) increased, whereas IL6 decreased in the bro-ALI. In the case of alv-ALI, enriched terms involving p53, APRIL (a proliferation-inducing ligand) tight junction, integrin kinase, and IL1 signaling were identified. These terms are associated with lung fibrosis. Further, significantly (p < 0.05) increased levels of secreted pro-inflammatory cytokines IFN\u03b3, IL1\ua7b5, IL2, IL4, IL6, IL8, IL10, IL13, and tumor necrosis factor alpha were detected in alv-ALI, whereas IL12 was decreased. Altered levels of these cytokines are also associated with lung fibrotic response.\r\n\r\nIn conclusion, we observed a typical anti-viral response in the bronchial model and a pro-fibrotic response in the alveolar model. The bro-ALI and alv-ALI models may serve as an easy and robust platform for assessing the pathogenicity of SARS-CoV-2 variants of concern at different lung regions.", "doi": "10.3390/v13122537", "pmid": "34960806", "labels": {"Category: Biochemistry": null, "Category: Vaccines": null, "Type: Journal article": null, "Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "v13122537"}, {"db": "pmc", "key": "PMC8708014"}, {"db": "URL", "key": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE185657", "description": "Gene Expression Omnibus database at NCBI (GSE185657)."}, {"db": "URL", "key": "https://www.mdpi.com/article/10.3390/v13122537/s1,", "description": "Supplementary material"}], "notes": [], "created": "2022-01-04T15:11:12.348Z", "modified": "2022-01-04T15:17:02.253Z"}, {"entity": "publication", "iuid": "7a685b9a808d41ba8d4943943ba9679f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a685b9a808d41ba8d4943943ba9679f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a685b9a808d41ba8d4943943ba9679f"}}, "title": "COVID-19 and Hygiene Hypothesis: increment of the Inflammatory Bowel Diseases in next generation?", "authors": [{"family": "Shahrbaf", "given": "Mohammad Amin", "initials": "MA"}, {"family": "Hassan", "given": "Moustapha", "initials": "M"}, {"family": "Vosough", "given": "Massoud", "initials": "M"}], "type": "editorial", "published": "2021-12-17", "journal": {"title": "Expert Rev Gastroenterol Hepatol", "issn": "1747-4132", "issn-l": null}, "abstract": null, "doi": "10.1080/17474124.2022.2020647", "pmid": "34919489", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-12-18T17:41:19.125Z", "modified": "2021-12-18T17:41:19.137Z"}, {"entity": "publication", "iuid": "dbfbeda66edb44c19af79e0644236fff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dbfbeda66edb44c19af79e0644236fff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dbfbeda66edb44c19af79e0644236fff"}}, "title": "Age-Stratified Risk of Cerebral Venous Sinus Thrombosis After SARS-CoV-2 Vaccination.", "authors": [{"family": "Krzywicka", "given": "Katarzyna", "initials": "K", "orcid": "0000-0002-9478-0401", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fca2d6da76f7470d8b22079b153956d4.json"}}, {"family": "van de Munckhof", "given": "Anita", "initials": "A"}, {"family": "S\u00e1nchez van Kammen", "given": "Mayte", "initials": "M", "orcid": "0000-0001-5614-9689", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae4f548088eb4c099837e35267755c0b.json"}}, {"family": "Heldner", "given": "Mirjam R", "initials": "MR", "orcid": "0000-0002-3594-2159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8280f8c6ea3a486abae8acc6aa491985.json"}}, {"family": "Jood", "given": "Katarina", "initials": "K"}, {"family": "Lindgren", "given": "Erik", "initials": "E", "orcid": "0000-0002-7628-5044", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e973b3c74ff4e5cba42da605a13bc61.json"}}, {"family": "Tatlisumak", "given": "Turgut", "initials": "T"}, {"family": "Putaala", "given": "Jukka", "initials": "J", "orcid": "0000-0002-6630-6104", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1930f3c097044b3a00d888744dab332.json"}}, {"family": "Kremer Hovinga", "given": "Johanna A", "initials": "JA", "orcid": "0000-0002-1300-7135", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f84022d8c60647929b2d7c45fa2e3849.json"}}, {"family": "Middeldorp", "given": "Saskia", "initials": "S"}, {"family": "Levi", "given": "Marcel M", "initials": "MM"}, {"family": "Cordonnier", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-5697-6892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba080d69348640eb90fba290f58fee11.json"}}, {"family": "Arnold", "given": "Marcel", "initials": "M"}, {"family": "Zwinderman", "given": "Aeilko H", "initials": "AH"}, {"family": "Ferro", "given": "Jos\u00e9 M", "initials": "JM"}, {"family": "Coutinho", "given": "Jonathan M", "initials": "JM", "orcid": "0000-0002-8284-982X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98cadafdcc044688bab25a3d7f9562b9.json"}}, {"family": "Aguiar de Sousa", "given": "Diana", "initials": "D"}], "type": "journal article", "published": "2021-12-17", "journal": {"title": "Neurology", "issn": "1526-632X", "issn-l": "0028-3878"}, "abstract": "Cerebral Venous Sinus Thrombosis (CVST) as a part of the thrombosis and thrombocytopenia syndrome is a rare adverse drug reaction of SARS-CoV-2 vaccination. Estimated background rate of CVST with thrombocytopenia is 0.1 per million per month. We assessed the age-stratified risk of CVST with and without thrombocytopenia after SARS-CoV-2 vaccination.\n\nWe estimated the absolute risk of CVST with and without thrombocytopenia within 28 days of first dose of four SARS-CoV-2 vaccinations, using data from the European Medicines Agency's EudraVigilance database (until 13 June 2021). As a denominator, we used data on vaccine delivery from 31 European countries. For 22.8 million adults from 25 countries, we estimated the absolute risk of CVST after the first dose of ChAdOx1 nCov-19 per age category.\n\nThe absolute risk of CVST within 28 days of first dose vaccination was 7.5 (95%CI 6.9-8.3), 0.7 (95%CI 0.2-2.4), 0.6 (95%CI 0.5-0.7) and 0.6 (95%CI 0.3-1.1) per million of first doses of ChAdOx1 nCov-19, Ad26.COV2.S, BNT162b2 and mRNA-1273, respectively. The absolute risk of CVST with thrombocytopenia within 28 days of first dose vaccination was 4.4 (95%CI 3.9-4.9), 0.7 (95%CI 0.2-2.4), 0.0 (95%CI 0.0-0.1) and 0.0 (95%CI 0.0-0.2) per million of first doses of ChAdOx1 nCov-19, Ad26.COV2.S, BNT162b2 and mRNA-1273, respectively. In recipients of ChAdOx1 nCov-19, the absolute risk of CVST, both with and without thrombocytopenia, was the highest in the 18-24 years age group (7.3 per million, 95%CI 2.8-18.8 and 3.7 per million, 95%CI 1.0-13.3, respectively). The risk of CVST with thrombocytopenia in ChAdOx1 nCov-19 recipients was the lowest in the age group\u226570 years (0.2, 95%CI 0.0-1.3). Age <60 compared to \u226560 was a predictor for CVST with thrombocytopenia (incidence rate ratio 5.79; 95%CI 2.98-11.24, p<0.001).\n\nThe risk of CVST with thrombocytopenia within 28 days of first dose vaccination with ChAdOx1 nCov-19 was higher in younger age groups. The risk of CVST with thrombocytopenia was slightly increased in patients receiving Ad26.COV2.S, compared with the estimated background risk. The risk of CVST with thrombocytopenia was not increased in recipients of SARS-CoV-2 mRNA vaccines.", "doi": "10.1212/WNL.0000000000013148", "pmid": "34921101", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "WNL.0000000000013148"}], "notes": [], "created": "2021-12-20T08:34:08.337Z", "modified": "2021-12-20T08:34:28.616Z"}, {"entity": "publication", "iuid": "a8981553df5d4274aaf529cd2b45a7f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8981553df5d4274aaf529cd2b45a7f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8981553df5d4274aaf529cd2b45a7f4"}}, "title": "", "authors": [{"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Fortea", "given": "Lydia", "initials": "L"}, {"family": "Pomarol-Clotet", "given": "Edith", "initials": "E"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Fullana", "given": "Miquel \u00c0ngel", "initials": "M\u00c0"}, {"family": "Solanes", "given": "Aleix", "initials": "A"}], "type": "case reports", "published": "2021-12-17", "journal": {"title": "Rev Psiquiatr Salud Ment", "issn": "1989-4600", "issn-l": null}, "abstract": null, "doi": "10.1016/j.rpsm.2021.12.004", "pmid": "34934465", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1888-9891(21)00134-8"}, {"db": "pmc", "key": "PMC8679503"}], "notes": [], "created": "2022-01-03T15:32:31.237Z", "modified": "2022-01-03T15:32:31.274Z"}, {"entity": "publication", "iuid": "05e8d837a24143c3978edafe2c1bf029", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/05e8d837a24143c3978edafe2c1bf029.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/05e8d837a24143c3978edafe2c1bf029"}}, "title": "Privacy Personas for IoT-Based Health Research: A Privacy Calculus Approach.", "authors": [{"family": "Maus", "given": "Benjamin", "initials": "B"}, {"family": "Olsson", "given": "Carl Magnus", "initials": "CM"}, {"family": "Salvi", "given": "Dario", "initials": "D"}], "type": "journal article", "published": "2021-12-16", "journal": {"title": "Front Digit Health", "issn": "2673-253X", "volume": "3", "pages": "675754", "issn-l": null}, "abstract": "The reliance on data donation from citizens as a driver for research, known as citizen science, has accelerated during the Sars-Cov-2 pandemic. An important enabler of this is Internet of Things (IoT) devices, such as mobile phones and wearable devices, that allow continuous data collection and convenient sharing. However, potentially sensitive health data raises privacy and security concerns for citizens, which research institutions and industries must consider. In e-commerce or social network studies of citizen science, a privacy calculus related to user perceptions is commonly developed, capturing the information disclosure intent of the participants. In this study, we develop a privacy calculus model adapted for IoT-based health research using citizen science for user engagement and data collection. Based on an online survey with 85 participants, we make use of the privacy calculus to analyse the respondents' perceptions. The emerging privacy personas are clustered and compared with previous research, resulting in three distinct personas which can be used by designers and technologists who are responsible for developing suitable forms of data collection. These are the 1) Citizen Science Optimist, the 2) Selective Data Donor, and the 3) Health Data Controller. Together with our privacy calculus for citizen science based digital health research, the three privacy personas are the main contributions of this study.", "doi": "10.3389/fdgth.2021.675754", "pmid": "34977856", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8716597"}], "notes": [], "created": "2022-01-04T14:43:51.211Z", "modified": "2022-01-04T14:43:51.251Z"}, {"entity": "publication", "iuid": "e070d5249b4e439f89b74961ed0f16fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e070d5249b4e439f89b74961ed0f16fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e070d5249b4e439f89b74961ed0f16fa"}}, "title": "Mechanistic Studies of an Automated Lipid Nanoparticle Reveal Critical Pharmaceutical Properties Associated with Enhanced mRNA Functional Delivery In Vitro and In Vivo.", "authors": [{"family": "Cui", "given": "Lili", "initials": "L", "orcid": "0000-0002-0668-2837", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a298a8143c1042e3a9bf00b0bc6dadd8.json"}}, {"family": "Hunter", "given": "Morag R", "initials": "MR"}, {"family": "Sonzini", "given": "Silvia", "initials": "S"}, {"family": "Pereira", "given": "Sara", "initials": "S"}, {"family": "Romanelli", "given": "Steven M", "initials": "SM"}, {"family": "Liu", "given": "Kai", "initials": "K"}, {"family": "Li", "given": "Weimin", "initials": "W"}, {"family": "Liang", "given": "Lihuan", "initials": "L"}, {"family": "Yang", "given": "Bin", "initials": "B"}, {"family": "Mahmoudi", "given": "Najet", "initials": "N"}, {"family": "Desai", "given": "Arpan S", "initials": "AS"}], "type": "journal article", "published": "2021-12-16", "journal": {"title": "Small", "issn": "1613-6829", "pages": "e2105832", "issn-l": null}, "abstract": "Recently, lipid nanoparticles (LNPs) have attracted attention due to their emergent use for COVID-19 mRNA vaccines. The success of LNPs can be attributed to ionizable lipids, which enable functional intracellular delivery. Previously, the authors established an automated high-throughput platform to screen ionizable lipids and identified that the LNPs generated using this automated technique show comparable or increased mRNA functional delivery in vitro as compared to LNPs prepared using traditional microfluidics techniques. In this study, the authors choose one benchmark lipid, DLin-MC3-DMA (MC3), and investigate whether the automated formulation technique can enhance mRNA functional delivery in vivo. Interestingly, a 4.5-fold improvement in mRNA functional delivery in vivo by automated LNPs as compared to LNPs formulated by conventional microfluidics techniques, is observed. Mechanistic studies reveal that particles with large size accommodate more mRNA per LNP, possess more hydrophobic surface, are more hemolytic, bind a larger protein corona, and tend to accumulate more in macropinocytosomes, which may quantitatively benefit mRNA cytosolic delivery. These data suggest that mRNA loading per particle is a critical factor that accounts for the enhanced mRNA functional delivery of automated LNPs. These mechanistic findings provide valuable insight underlying the enhanced mRNA functional delivery to accelerate future mRNA LNP product development.", "doi": "10.1002/smll.202105832", "pmid": "34914866", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:35:48.170Z", "modified": "2022-01-04T15:36:24.454Z"}, {"entity": "publication", "iuid": "54d97da6ea8f443aa5ddb6a2e05821cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54d97da6ea8f443aa5ddb6a2e05821cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54d97da6ea8f443aa5ddb6a2e05821cc"}}, "title": "An Integrated Deep Learning and Belief Rule Base Intelligent System to Predict Survival of COVID-19 Patient under Uncertainty.", "authors": [{"family": "Ahmed", "given": "Tawsin Uddin", "initials": "TU"}, {"family": "Jamil", "given": "Mohammad Newaj", "initials": "MN"}, {"family": "Hossain", "given": "Mohammad Shahadat", "initials": "MS"}, {"family": "Islam", "given": "Raihan Ul", "initials": "RU", "orcid": "0000-0002-3090-7645", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/597e3542e3fb49d881e100f33115eaf3.json"}}, {"family": "Andersson", "given": "Karl", "initials": "K"}], "type": "journal article", "published": "2021-12-16", "journal": {"title": "Cognit Comput", "issn": "1866-9956", "pages": "1-17", "issn-l": null}, "abstract": "The novel Coronavirus-induced disease COVID-19 is the biggest threat to human health at the present time, and due to the transmission ability of this virus via its conveyor, it is spreading rapidly in almost every corner of the globe. The unification of medical and IT experts is required to bring this outbreak under control. In this research, an integration of both data and knowledge-driven approaches in a single framework is proposed to assess the survival probability of a COVID-19 patient. Several neural networks pre-trained models: Xception, InceptionResNetV2, and VGG Net, are trained on X-ray images of COVID-19 patients to distinguish between critical and non-critical patients. This prediction result, along with eight other significant risk factors associated with COVID-19 patients, is analyzed with a knowledge-driven belief rule-based expert system which forms a probability of survival for that particular patient. The reliability of the proposed integrated system has been tested by using real patient data and compared with expert opinion, where the performance of the system is found promising.", "doi": "10.1007/s12559-021-09978-8", "pmid": "34931129", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "9978"}, {"db": "pmc", "key": "PMC8674031"}], "notes": [], "created": "2022-01-03T15:30:04.377Z", "modified": "2022-01-03T15:30:20.090Z"}, {"entity": "publication", "iuid": "09bb87f27350469aae706ca7d2cc2b45", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/09bb87f27350469aae706ca7d2cc2b45.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/09bb87f27350469aae706ca7d2cc2b45"}}, "title": "[Insights from creating a covid-19 biobank in Sweden].", "authors": [{"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Cornillet", "given": "Martin", "initials": "M"}, {"family": "Rooijackers", "given": "Olav", "initials": "O"}, {"family": "I Eriksson", "given": "Lars", "initials": "L"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas", "initials": "N"}], "type": "journal article", "published": "2021-12-15", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "volume": "118", "issn-l": "0023-7205"}, "abstract": "Biobanks function as important repositories for biological samples collected in health care. As such, they play an important role in enabling important medical research over time. In response to the covid-19 outbreak in Stockholm, Sweden, a group of specialists in intensive care, infectious diseases, and clinical microbiology, as well as scientists with experience in immunology and viral diseases, rapidly gathered. The group discussed how to cope with the prevailing situation, both from a clinical and a research-oriented perspective. Among strategies decided was an attempt to rapidly organize a biological sample collection organized in a biobank for immediate but also long-term research purposes. Given the pandemic conditions with a new virus, the biobank project and associated immediate immunological research tasks turned out to be challenging. In the following months, many lessons were learned from the systematic collection of clinical samples and associated immunological research. Many insights were gained of value for future pandemic preparedness.", "doi": null, "pmid": "34910294", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "21163"}], "notes": [], "created": "2021-12-18T17:49:56.486Z", "modified": "2023-01-13T13:31:26.174Z"}, {"entity": "publication", "iuid": "2a414026535b44c6829650be10fddf84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2a414026535b44c6829650be10fddf84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2a414026535b44c6829650be10fddf84"}}, "title": "Promoting a Syndemic Approach for Cardiometabolic Disease Management During COVID-19: The CAPISCO International Expert Panel.", "authors": [{"family": "Al Mahmeed", "given": "Wael", "initials": "W"}, {"family": "Al-Rasadi", "given": "Khalid", "initials": "K"}, {"family": "Banerjee", "given": "Yajnavalka", "initials": "Y"}, {"family": "Ceriello", "given": "Antonio", "initials": "A"}, {"family": "Cosentino", "given": "Francesco", "initials": "F"}, {"family": "Galia", "given": "Massimo", "initials": "M"}, {"family": "Goh", "given": "Su-Yen", "initials": "SY"}, {"family": "Kempler", "given": "Peter", "initials": "P"}, {"family": "Lessan", "given": "Nader", "initials": "N"}, {"family": "Papanas", "given": "Nikolaos", "initials": "N"}, {"family": "Rizvi", "given": "Ali A", "initials": "AA"}, {"family": "Santos", "given": "Raul D", "initials": "RD"}, {"family": "Stoian", "given": "Anca P", "initials": "AP"}, {"family": "Toth", "given": "Peter P", "initials": "PP"}, {"family": "Rizzo", "given": "Manfredi", "initials": "M"}, {"family": "CArdiometabolic Panel of International experts on Syndemic COvid-19 (CAPISCO)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-15", "journal": {"title": "Front Cardiovasc Med", "issn": "2297-055X", "volume": "8", "pages": "787761", "issn-l": null}, "abstract": "Efforts in the fight against COVID-19 are achieving success in many parts of the world, although progress remains slow in other regions. We believe that a syndemic approach needs to be adopted to address this pandemic given the strong apparent interplay between COVID-19, its related complications, and the socio-structural environment. We have assembled an international, multidisciplinary group of researchers and clinical practitioners to promote a novel syndemic approach to COVID-19: the CArdiometabolic Panel of International experts on Syndemic COvid-19 (CAPISCO). This geographically diverse group aims to facilitate collaborative-networking and scientific exchanges between researchers and clinicians facing a multitude of challenges on different continents during the pandemic. In the present article we present our \"manifesto\", with the intent to provide evidence-based guidance to the global medical and scientific community for better management of patients both during and after the current pandemic.", "doi": "10.3389/fcvm.2021.787761", "pmid": "34977193", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8715947"}], "notes": [], "created": "2022-01-04T14:44:36.587Z", "modified": "2022-01-04T14:44:36.601Z"}, {"entity": "publication", "iuid": "bfe0bc74fda7427ea3ac315a88fe927d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bfe0bc74fda7427ea3ac315a88fe927d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bfe0bc74fda7427ea3ac315a88fe927d"}}, "title": "Experiences of Online COVID-19 Information Acquisition among Persons with Type 2 Diabetes and Varying eHealth Literacy.", "authors": [{"family": "Sj\u00f6str\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Hajdarevic", "given": "Senada", "initials": "S", "orcid": "0000-0003-0661-8269", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9575f7283b80416997f0b3ef20e487b2.json"}}, {"family": "H\u00f6rnsten", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "\u00d6berg", "given": "Ulrika", "initials": "U", "orcid": "0000-0002-2803-8006", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49f675b644a844159d0154b032fec924.json"}}, {"family": "Isaksson", "given": "Ulf", "initials": "U", "orcid": "0000-0001-5191-4599", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac5e6ad1dacd498980527d25095c895f.json"}}], "type": "journal article", "published": "2021-12-15", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "24", "issn-l": null}, "abstract": "During the COVID-19 pandemic, the Internet has been a major source of information for people to keep updated with news and guidelines. However, concerns have been raised about the 'infodemic', which includes the overabundance of online information and the spread of misleading information. Adequate eHealth literacy skills among world citizens have therefore been emphasized as vital during the pandemic. Persons with type 2 diabetes have been at increased risk of severe outcomes of COVID-19 disease. This study aimed to explore online COVID-19 information acquisition experiences among persons with type 2 diabetes and varying eHealth literacy. Fifty-eight participants filled out the eHealth Literacy Scale (eHEALS), along with a qualitative questionnaire with free-text questions. Additionally, 10 participants were interviewed. Thematic analysis was applied to identify patterns in participants' experiences. Two domains were identified: perceived challenges with online information about COVID-19, and coping strategies to manage challenges. The perceived challenges were: being exposed to information overload, dealing with conflicting information, and being strongly emotionally affected. The related coping strategies were: protecting oneself, trusting authorities, taking command, and using common sense. These strategies often involved triangulation of the information obtained, including participants consulting their common sense, various sources, or family and friends. This paper highlights the crucial role of authorities in delivering online information, that according to health literacy principles, is easy to access, understand, and use. Furthermore, our results reinforce the importance of diabetes nurses, as well as healthcare professionals in general, in encouraging patients to share their Internet findings, promote information from reliable sources, and deliver tailored information that suits individual needs. Because our results underline the importance of social support in eHealth literacy and the assessment of online health information, the inclusion of family and friends needs to be increasingly considered in diabetes care. Due to the small homogenous sample, the results of this study cannot be generalized. However, the reader can assess the transferability to other situations and settings based on our contextual descriptions.", "doi": "10.3390/ijerph182413240", "pmid": "34948852", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182413240"}, {"db": "pmc", "key": "PMC8701656"}], "notes": [], "created": "2022-01-04T15:29:32.581Z", "modified": "2022-01-04T15:29:32.750Z"}, {"entity": "publication", "iuid": "ba0357094cd74fde9ff8bf38087793f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ba0357094cd74fde9ff8bf38087793f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ba0357094cd74fde9ff8bf38087793f7"}}, "title": "Dapagliflozin in patients with COVID-19: mind the kidneys - Authors' reply.", "authors": [{"family": "Kosiborod", "given": "Mikhail N", "initials": "MN"}, {"family": "Esterline", "given": "Russell", "initials": "R"}, {"family": "Oscarsson", "given": "Jan", "initials": "J"}, {"family": "Gasparyan", "given": "Samvel B", "initials": "SB"}, {"family": "Furtado", "given": "Remo H M", "initials": "RHM"}, {"family": "Verma", "given": "Subodh", "initials": "S"}, {"family": "Berwanger", "given": "Otavio", "initials": "O"}], "type": "letter", "published": "2021-12-15", "journal": {"title": "Lancet Diabetes Endocrinol", "issn": "2213-8595", "issn-l": null}, "abstract": null, "doi": "10.1016/S2213-8587(21)00326-0", "pmid": "34921753", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-8587(21)00326-0"}], "notes": [], "created": "2021-12-20T08:33:08.636Z", "modified": "2021-12-20T08:33:08.651Z"}, {"entity": "publication", "iuid": "c58762d3b71e4eaba096566c42f6a804", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c58762d3b71e4eaba096566c42f6a804.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c58762d3b71e4eaba096566c42f6a804"}}, "title": "Acute COVID-19 severity and 16-month mental morbidity trajectories in patient populations of six nations", "authors": [{"family": "Magn\u00fasd\u00f3ttir", "given": "Ingibj\u00f6rg", "initials": "I", "orcid": "0000-0002-1983-6049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/774d5ab207a74688accb27001d15e4aa.json"}}, {"family": "Lovik", "given": "Anik\u00f3", "initials": "A"}, {"family": "Unnarsd\u00f3ttir", "given": "Anna B\u00e1ra", "initials": "AB", "orcid": "0000-0002-6421-445X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2da21ebd675c4e329c47bf64bbc1578a.json"}}, {"family": "McCartney", "given": "Daniel", "initials": "D"}, {"family": "Ask", "given": "Helga", "initials": "H"}, {"family": "K\u00f5iv", "given": "Kadri", "initials": "K"}, {"family": "Nordahl Christoffersen", "given": "Lea Arregui", "initials": "LA"}, {"family": "Johnson", "given": "Sverre Urnes", "initials": "SU"}, {"family": "McIntosh", "given": "Andrew", "initials": "A", "orcid": "0000-0002-0198-4588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc50c9e995964aa5be11a155b7f95c64.json"}}, {"family": "K\u00e4hler", "given": "Anna K", "initials": "AK"}, {"family": "Campbell", "given": "Archie", "initials": "A"}, {"family": "Hauksd\u00f3ttir", "given": "Arna", "initials": "A"}, {"family": "Fawns-Ritchie", "given": "Chloe", "initials": "C"}, {"family": "Erikstrup", "given": "Christian", "initials": "C", "orcid": "0000-0001-6551-6647", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f01382b51d3e46d8b8c9d74dbed3ce81.json"}}, {"family": "Helenius", "given": "Dorte", "initials": "D"}, {"family": "Altschul", "given": "Drew", "initials": "D"}, {"family": "Thordardottir", "given": "Edda Bjork", "initials": "EB"}, {"family": "Ey\u00fe\u00f3rsson", "given": "El\u00edas", "initials": "E"}, {"family": "Frans", "given": "Emma M", "initials": "EM"}, {"family": "T\u00f3masson", "given": "Gunnar", "initials": "G"}, {"family": "J\u00f3nsd\u00f3ttir", "given": "Harpa Lind", "initials": "HL"}, {"family": "R\u00fanarsd\u00f3ttir", "given": "Harpa", "initials": "H"}, {"family": "Hjalgrim", "given": "Henrik", "initials": "H"}, {"family": "Har\u00f0ard\u00f3ttir", "given": "Hr\u00f6nn", "initials": "H"}, {"family": "Gonz\u00e1lez-Hij\u00f3n", "given": "Juan", "initials": "J"}, {"family": "Banasik", "given": "Karina", "initials": "K"}, {"family": "Dinh", "given": "Khoa Manh", "initials": "KM"}, {"family": "Lu", "given": "Li", "initials": "L"}, {"family": "Milani", "given": "Lili", "initials": "L"}, {"family": "Trogstad", "given": "Lill", "initials": "L"}, {"family": "Didriksen", "given": "Maria", "initials": "M"}, {"family": "Ebrahimi", "given": "Omid V", "initials": "OV"}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF"}, {"family": "Magnus", "given": "Per Minor", "initials": "PM"}, {"family": "Shen", "given": "Qing", "initials": "Q"}, {"family": "Nesv\u00e5g", "given": "Ragnar", "initials": "R"}, {"family": "M\u00e4gi", "given": "Reedik", "initials": "R"}, {"family": "P\u00e1lsson", "given": "Run\u00f3lfur", "initials": "R", "orcid": "0000-0001-6763-1702", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df1c1ec369a54d3ba12048edb675ab6a.json"}}, {"family": "Ostrowski", "given": "Sisse Rye", "initials": "SR"}, {"family": "Werge", "given": "Thomas", "initials": "T"}, {"family": "Hoffart", "given": "Asle", "initials": "A"}, {"family": "Porteous", "given": "David J", "initials": "DJ"}, {"family": "Fang", "given": "Fang", "initials": "F", "orcid": "0000-0002-3310-6456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b0852465cd14239a25329b976172792.json"}}, {"family": "Jakobsd\u00f3ttir", "given": "J\u00f3hanna", "initials": "J"}, {"family": "Lehto", "given": "Kelli", "initials": "K"}, {"family": "Andreassen", "given": "Ole A", "initials": "OA", "orcid": "0000-0002-4461-3568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f105232b5e5a443abbc17ac88f9b4ad6.json"}}, {"family": "Pedersen", "given": "Ole B V", "initials": "OBV"}, {"family": "Aspelund", "given": "Thor", "initials": "T", "orcid": "0000-0002-7998-5433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f3b5030190743e4b0ec0be05afb8fa8.json"}}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur Anna", "initials": "UA", "orcid": "0000-0001-5382-946X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87d1dbec7c6f4942b1db2b999eeb9ece.json"}}], "type": "posted-content", "published": "2021-12-15", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.12.13.21267368", "pmid": null, "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2023-02-13T18:39:49.120Z", "modified": "2023-02-13T18:39:49.262Z"}, {"entity": "publication", "iuid": "603e4932d45040fe8bf99638dd6c7b31", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/603e4932d45040fe8bf99638dd6c7b31.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/603e4932d45040fe8bf99638dd6c7b31"}}, "title": "The impact of the COVID-19 school closure on adolescents\u2019 use of mental healthcare services in Sweden", "authors": [{"family": "Svaleryd", "given": "Helena", "initials": "H", "orcid": "0000-0003-3072-5224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79dfce3f625e418490cac3f369f3e9e8.json"}}, {"family": "Bj\u00f6rkegren", "given": "Evelina", "initials": "E"}, {"family": "Vlachos", "given": "Jonas", "initials": "J", "orcid": "0000-0002-7717-9155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b8b751862ab4c34b580e5ace974b36c.json"}}], "type": "posted-content", "published": "2021-12-14", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.12.12.21267684", "pmid": null, "labels": {"Category: Other": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:45:44.699Z", "modified": "2022-11-22T05:43:32.647Z"}, {"entity": "publication", "iuid": "b027237f614b41f59ccd65d0b432edea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b027237f614b41f59ccd65d0b432edea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b027237f614b41f59ccd65d0b432edea"}}, "title": "Harnessing Twitter data to survey public attention and attitudes towards COVID-19 vaccines in the UK.", "authors": [{"family": "Fazel", "given": "Seena", "initials": "S"}, {"family": "Zhang", "given": "Le", "initials": "L"}, {"family": "Javid", "given": "Babak", "initials": "B"}, {"family": "Brikell", "given": "Isabell", "initials": "I"}, {"family": "Chang", "given": "Zheng", "initials": "Z"}], "type": "journal article", "published": "2021-12-14", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "23402", "issn-l": "2045-2322"}, "abstract": "Attitudes to COVID-19 vaccination vary considerably within and between countries. Although the contribution of socio-demographic factors to these attitudes has been studied, the role of social media and how it interacts with news about vaccine development and efficacy is uncertain. We examined around 2 million tweets from 522,893 persons in the UK from November 2020 to January 2021 to evaluate links between Twitter content about vaccines and major scientific news announcements about vaccines. The proportion of tweets with negative vaccine content varied, with reductions of 20-24% on the same day as major news announcement. However, the proportion of negative tweets reverted back to an average of around 40% within a few days. Engagement rates were higher for negative tweets. Public health messaging could consider the dynamics of Twitter-related traffic and the potential contribution of more targeted social media campaigns to address vaccine hesitancy.", "doi": "10.1038/s41598-021-02710-4", "pmid": "34907201", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-02710-4"}], "notes": [], "created": "2021-12-18T17:53:48.734Z", "modified": "2021-12-18T17:53:48.747Z"}, {"entity": "publication", "iuid": "0e9ffe8c65604633a45f7f253a9ee75f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e9ffe8c65604633a45f7f253a9ee75f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e9ffe8c65604633a45f7f253a9ee75f"}}, "title": "Estimating the SARS-CoV-2 infected population fraction and the infection-to-fatality ratio: a data-driven case study based on Swedish time series data.", "authors": [{"family": "Wacker", "given": "Andreas", "initials": "A"}, {"family": "J\u00f6ud", "given": "Anna", "initials": "A", "orcid": "0000-0001-7192-4911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e038a5ce2f5a47bd89e7c221651a3d24.json"}}, {"family": "Bernhardsson", "given": "Bo", "initials": "B"}, {"family": "Gerlee", "given": "Philip", "initials": "P", "orcid": "0000-0001-8503-0177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ba426c1ab741e781d2b9cd09a0b830.json"}}, {"family": "Gustafsson", "given": "Fredrik", "initials": "F"}, {"family": "Soltesz", "given": "Kristian", "initials": "K"}], "type": "journal article", "published": "2021-12-14", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "23963", "issn-l": "2045-2322"}, "abstract": "We demonstrate that finite impulse response (FIR) models can be applied to analyze the time evolution of an epidemic with its impact on deaths and healthcare strain. Using time series data for COVID-19-related cases, ICU admissions and deaths from Sweden, the FIR model gives a consistent epidemiological trajectory for a simple delta filter function. This results in a consistent scaling between the time series if appropriate time delays are applied and allows the reconstruction of cases for times before July 2020, when RT-PCR testing was not widely available. Combined with randomized RT-PCR study results, we utilize this approach to estimate the total number of infections in Sweden, and the corresponding infection-to-fatality ratio (IFR), infection-to-case ratio (ICR), and infection-to-ICU admission ratio (IIAR). Our values for IFR, ICR and IIAR are essentially constant over large parts of 2020 in contrast with claims of healthcare adaptation or mutated virus variants importantly affecting these ratios. We observe a diminished IFR in late summer 2020 as well as a strong decline during 2021, following the launch of a nation-wide vaccination program. The total number of infections during 2020 is estimated to 1.3 million, indicating that Sweden was far from herd immunity.", "doi": "10.1038/s41598-021-03269-w", "pmid": "34907208", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8671402"}, {"db": "pii", "key": "10.1038/s41598-021-03269-w"}], "notes": [], "created": "2021-12-18T17:52:24.620Z", "modified": "2023-06-19T15:31:02.834Z"}, {"entity": "publication", "iuid": "fcca4b56268f4b11ba3093964206d768", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fcca4b56268f4b11ba3093964206d768.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fcca4b56268f4b11ba3093964206d768"}}, "title": "ECG pathology and its association with death in critically ill COVID-19 patients, a cohort study.", "authors": [{"family": "Ros\u00e9n", "given": "Jacob", "initials": "J", "orcid": "0000-0001-9518-5834", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ce3d5b2cb914d72bbd476b7e1127c8d.json"}}, {"family": "Noreland", "given": "Maria", "initials": "M"}, {"family": "Stattin", "given": "Karl", "initials": "K"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Malinovschi", "given": "Andrei", "initials": "A"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Uppsala Intensive Care COVID-19 Research Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-14", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "12", "pages": "e0261315"}, "abstract": "We investigated the prevalence of ECG abnormalities and their association with mortality, organ dysfunction and cardiac biomarkers in a cohort of COVID-19 patients admitted to the intensive care unit (ICU).\r\n\r\nThis cohort study included patients with COVID-19 admitted to the ICU of a tertiary hospital in Sweden. ECG, clinical data and laboratory findings during ICU stay were extracted from medical records and ECGs obtained near ICU admission were reviewed by two independent physicians.\r\n\r\nEighty patients had an acceptable ECG near ICU-admission. In the entire cohort 30-day mortality was 28%. Compared to patients with normal ECG, among whom 30-day mortality was 16%, patients with ECG fulfilling criteria for prior myocardial infarction had higher mortality, 63%, odds ratio (OR) 9.61 (95% confidence interval (CI) 2.02-55.6) adjusted for Simplified Acute Physiology Score 3 and patients with ST-T abnormalities had 50% mortality and OR 6.05 (95% CI 1.82-21.3) in univariable analysis. Both prior myocardial infarction pattern and ST-T pathology were associated with need for vasoactive treatment and higher peak plasma levels of troponin-I, NT-pro-BNP (N-terminal pro-Brain Natriuretic Peptide), and lactate during ICU stay compared to patients with normal ECG.\r\n\r\nECG with prior myocardial infarction pattern or acute ST-T pathology at ICU admission is associated with death, need for vasoactive treatment and higher levels of biomarkers of cardiac damage and strain in severely ill COVID-19 patients, and should alert clinicians to a poor prognosis.", "doi": "10.1371/journal.pone.0261315", "pmid": "34905575", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Public Health": null, "Funder: VR": null, "Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-28860"}, {"db": "pmc", "key": "PMC8670711"}, {"db": "URL", "key": "https://doi.org/10.1371/journal.pone.0261315.s001", "description": "https://doi.org/10.1371/journal.pone.0261315.s001"}, {"db": "URL", "key": "https://doi.org/10.17044/scilifelab.14229410.v1", "description": "https://doi.org/10.17044/scilifelab.14229410.v1"}], "notes": [], "created": "2021-12-18T17:54:37.568Z", "modified": "2021-12-18T17:57:22.337Z"}, {"entity": "publication", "iuid": "144f781f894f4fa89b8d27a5bb748f5c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/144f781f894f4fa89b8d27a5bb748f5c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/144f781f894f4fa89b8d27a5bb748f5c"}}, "title": "Does Confinement Affect Treatment Dropout Rates in Patients With Gambling Disorder? A Nine-Month Observational Study.", "authors": [{"family": "Baenas", "given": "Isabel", "initials": "I"}, {"family": "Etxandi", "given": "Mikel", "initials": "M"}, {"family": "Codina", "given": "Ester", "initials": "E"}, {"family": "Granero", "given": "Roser", "initials": "R"}, {"family": "Fern\u00e1ndez-Aranda", "given": "Fernando", "initials": "F"}, {"family": "G\u00f3mez-Pe\u00f1a", "given": "M\u00f3nica", "initials": "M"}, {"family": "Moragas", "given": "Laura", "initials": "L"}, {"family": "Rivas", "given": "Sandra", "initials": "S"}, {"family": "Potenza", "given": "Marc N", "initials": "MN"}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "Del Pino-Guti\u00e9rrez", "given": "Amparo", "initials": "A"}, {"family": "Mora-Maltas", "given": "Bernat", "initials": "B"}, {"family": "Valenciano-Mendoza", "given": "Eduardo", "initials": "E"}, {"family": "Mench\u00f3n", "given": "Jos\u00e9 M", "initials": "JM"}, {"family": "Jim\u00e9nez-Murcia", "given": "Susana", "initials": "S"}], "type": "journal article", "published": "2021-12-14", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "761802", "issn-l": "1664-1078"}, "abstract": "Background and Aims: COVID-19 pandemic and confinement have represented a challenge for patients with gambling disorder (GD). Regarding treatment outcome, dropout may have been influenced by these adverse circumstances. The aims of this study were: (a) to analyze treatment dropout rates in patients with GD throughout two periods: during and after the lockdown and (b) to assess clinical features that could represent vulnerability factors for treatment dropout. Methods: The sample consisted of n=86 adults, mostly men (n=79, 91.9%) and with a mean age of 45years old (SD=16.85). Patients were diagnosed with GD according to DSM-5 criteria and were undergoing therapy at a Behavioral Addiction Unit when confinement started. Clinical data were collected through a semi-structured interview and protocolized psychometric assessment. A brief telephone survey related to COVID-19 concerns was also administered at the beginning of the lockdown. Dropout data were evaluated at two moments throughout a nine-month observational period (T1: during the lockdown, and T2: after the lockdown). Results: The risk of dropout during the complete observational period was R=32/86=0.372 (37.2%), the Incidence Density Rate (IDR) ratio T2/T1 being equal to 0.052/0.033=1.60 (p=0.252). Shorter treatment duration (p=0.007), lower anxiety (p=0.025), depressive symptoms (p=0.045) and lower use of adaptive coping strategies (p=0.046) characterized patients who abandoned treatment during the lockdown. Briefer duration of treatment (p=0.001) and higher employment concerns (p=0.044) were highlighted in the individuals who dropped out after the lockdown. Treatment duration was a predictor of dropout in both periods (p=0.005 and p<0.001, respectively). Conclusion: The present results suggest an impact of the COVID-19 pandemic on treatment dropout among patients with GD during and after the lockdown, being treatment duration a predictor of dropout. Assessing vulnerability features in GD may help clinicians identify high-risk individuals and enhance prevention and treatment approaches in future similar situations.", "doi": "10.3389/fpsyg.2021.761802", "pmid": "34970193", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8712884"}], "notes": [], "created": "2022-01-04T14:58:37.916Z", "modified": "2022-01-04T14:58:37.933Z"}, {"entity": "publication", "iuid": "7ac9e51b73514b76bbabcc91dab96516", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7ac9e51b73514b76bbabcc91dab96516.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7ac9e51b73514b76bbabcc91dab96516"}}, "title": "Comprehensive Contact Tracing, Testing and Sequencing Show Limited Transmission of SARS-CoV-2 between Children in Schools in Norway, August 2020 to May 2021.", "authors": [{"family": "Winje", "given": "Brita Askeland", "initials": "BA", "orcid": "0000-0003-2858-7248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff6f41b97fb5447cb80574cb6e671a80.json"}}, {"family": "Ofitserova", "given": "Trine Skogset", "initials": "TS"}, {"family": "Brynildsrud", "given": "Ola Br\u00f8nstad", "initials": "OB"}, {"family": "Greve-Isdahl", "given": "Margrethe", "initials": "M"}, {"family": "Bragstad", "given": "Karoline", "initials": "K"}, {"family": "Rykkvin", "given": "Rikard", "initials": "R"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "Lund", "given": "Hilde Marie", "initials": "HM"}, {"family": "Nyg\u00e5rd", "given": "Karin", "initials": "K"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}, {"family": "Brandal", "given": "Lin Thorstensen", "initials": "LT"}], "type": "journal article", "published": "2021-12-14", "journal": {"title": "Microorganisms", "issn": "2076-2607", "volume": "9", "issue": "12", "issn-l": "2076-2607"}, "abstract": "The role of children in the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in schools has been a topic of controversy. In this study among school contacts of SARS-CoV-2 positive children in 43 contact-investigations, we investigated SARS-CoV-2 transmission in Norway, August 2020-May 2021. All participants were tested twice within seven to ten days, using SARS-CoV-2 PCR on home-sampled saliva. Positive samples were whole genome sequenced. Among the 559 child contacts, eight tested positive (1.4%, 95% CI 0.62-2.80), with no significant difference between primary (1.0%, 95% CI 0.27-2.53) and secondary schools (2.6%, 95% CI 0.70-6.39), p = 0.229, nor by viral strain, non-Alpha (1.4%, 95% CI 0.50-2.94) and Alpha variant (B.1.1.7) (1.7%, 95% CI 0.21-5.99), p = 0.665. One adult contact (1/100) tested positive. In 34 index cases, we detected 13 different SARS-CoV-2 Pango lineage variants, with B.1.1.7 being most frequent. In the eight contact-investigations with SARS-CoV-2 positive contacts, four had the same sequence identity as the index, one had no relation, and three were inconclusive. With mitigation measures in place, the spread of SARS-CoV-2 from children in schools is limited. By excluding contact-investigations with adult cases known at the time of enrolment, our data provide a valid estimate on the role of children in the transmission of SARS-CoV-2 in schools.", "doi": "10.3390/microorganisms9122587", "pmid": "34946187", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "microorganisms9122587"}, {"db": "pmc", "key": "PMC8705768"}], "notes": [], "created": "2022-01-04T15:31:42.547Z", "modified": "2022-01-04T15:31:42.605Z"}, {"entity": "publication", "iuid": "8f1e7fb4b8374e2eb1cda889dcc4a2b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f1e7fb4b8374e2eb1cda889dcc4a2b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f1e7fb4b8374e2eb1cda889dcc4a2b2"}}, "title": "Broad anti-SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1/mRNA-1273 prime-boost vaccination", "authors": [{"family": "Kaku", "given": "Chengzi I", "initials": "CI", "orcid": "0000-0002-9854-8351", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be56dead52324203a9b37fc32f23626f.json"}}, {"family": "Champney", "given": "Elizabeth R", "initials": "ER"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Johnson", "given": "Carl E", "initials": "CE"}, {"family": "Ahlm", "given": "Clas", "initials": "C", "orcid": "0000-0003-2018-8592", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/833d0293b5d74bbabec63e922cd19d54.json"}}, {"family": "Sakharkar", "given": "Mrunal", "initials": "M", "orcid": "0000-0002-2717-5201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2694a69ce874c3f93cf4f9ed8d736dd.json"}}, {"family": "Ackerman", "given": "Margaret E", "initials": "ME", "orcid": "0000-0002-4253-3476", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10fea712c93441dd922bbcb531b46148.json"}}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE", "orcid": "0000-0001-6904-742X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e41c0e1c9c7b499fb3d844d4c572e7bb.json"}}, {"family": "Walker", "given": "Laura M", "initials": "LM", "orcid": "0000-0001-7704-3197", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a40fc6cfefc14436a12cc467c3cacd54.json"}}], "type": "posted-content", "published": "2021-12-14", "journal": {"title": "MedRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.12.13.21267598", "pmid": null, "labels": {"Type: Preprint": null, "Category: Vaccines": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Research Area: Vaccine": null, "Funder: VR": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:46:15.910Z", "modified": "2022-02-14T14:55:09.518Z"}, {"entity": "publication", "iuid": "9633f53476a44e038f64329f6684a8ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9633f53476a44e038f64329f6684a8ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9633f53476a44e038f64329f6684a8ee"}}, "title": "Biomarkers Predict In-Hospital Major Adverse Cardiac Events in COVID-19 Patients: A Multicenter International Study.", "authors": [{"family": "Henein", "given": "Michael Y", "initials": "MY", "orcid": "0000-0002-6089-5614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe79bb10eb4348948599443b7b396faf.json"}}, {"family": "Mandoli", "given": "Giulia Elena", "initials": "GE", "orcid": "0000-0002-3184-3006", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc927b7843b44bdd87232563c7faff19.json"}}, {"family": "Pastore", "given": "Maria Concetta", "initials": "MC", "orcid": "0000-0002-7223-141X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/55e79d1bf0294864ae1cdb57aa4a4844.json"}}, {"family": "Ghionzoli", "given": "Nicol\u00f2", "initials": "N"}, {"family": "Hasson", "given": "Fouhad", "initials": "F"}, {"family": "Nisar", "given": "Muhammad K", "initials": "MK", "orcid": "0000-0002-5132-3972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/57bb7f7ab7c04904a4c0032679c32880.json"}}, {"family": "Islam", "given": "Mohammed", "initials": "M"}, {"family": "Bandera", "given": "Francesco", "initials": "F"}, {"family": "Marrocco-Trischitta", "given": "Massimiliano M", "initials": "MM"}, {"family": "Baroni", "given": "Irene", "initials": "I"}, {"family": "Malagoli", "given": "Alessandro", "initials": "A", "orcid": "0000-0001-9119-4311", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3808163253445a0923454d2df22ad30.json"}}, {"family": "Rossi", "given": "Luca", "initials": "L"}, {"family": "Biagi", "given": "Andrea", "initials": "A"}, {"family": "Citro", "given": "Rodolfo", "initials": "R"}, {"family": "Ciccarelli", "given": "Michele", "initials": "M", "orcid": "0000-0003-2379-1960", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d76634bdc8024f53ba78a6e72ab3d041.json"}}, {"family": "Silverio", "given": "Angelo", "initials": "A", "orcid": "0000-0001-9749-8092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/610b8ded802247ceb13def87bcc5a1d7.json"}}, {"family": "Biagioni", "given": "Giulia", "initials": "G"}, {"family": "Moutiris", "given": "Joseph A", "initials": "JA"}, {"family": "Vancheri", "given": "Federico", "initials": "F", "orcid": "0000-0002-5268-063X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c112118f1d94c1a95466127919064e4.json"}}, {"family": "Mazzola", "given": "Giovanni", "initials": "G"}, {"family": "Geraci", "given": "Giulio", "initials": "G"}, {"family": "Thomas", "given": "Liza", "initials": "L"}, {"family": "Altman", "given": "Mikhail", "initials": "M"}, {"family": "Pernow", "given": "John", "initials": "J"}, {"family": "Ahmed", "given": "Mona", "initials": "M", "orcid": "0000-0002-9579-1380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4164b11cface4f849c5e08bf41c8c5d9.json"}}, {"family": "Santoro", "given": "Ciro", "initials": "C", "orcid": "0000-0002-6329-1680", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2e9af60986147238aff6cd0dd5e9600.json"}}, {"family": "Esposito", "given": "Roberta", "initials": "R"}, {"family": "Casas", "given": "Guillem", "initials": "G", "orcid": "0000-0001-7122-320X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f0ed65a87cc40a28c45996b0510981a.json"}}, {"family": "Fern\u00e1ndez-Galera", "given": "Rub\u00e9n", "initials": "R"}, {"family": "Gonzalez", "given": "Maribel", "initials": "M"}, {"family": "Rodriguez Palomares", "given": "Jose", "initials": "J"}, {"family": "Byty\u00e7i", "given": "Ibadete", "initials": "I", "orcid": "0000-0002-8996-4257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba2f218876104573a8e529b1c2b6f671.json"}}, {"family": "Dini", "given": "Frank Lloyd", "initials": "FL", "orcid": "0000-0003-1458-4820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/548dbd176bf0475b8c70c8942610312b.json"}}, {"family": "Cameli", "given": "Paolo", "initials": "P", "orcid": "0000-0001-8639-2882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30defb513b86480dbeb48f1b75c95327.json"}}, {"family": "Franchi", "given": "Federico", "initials": "F"}, {"family": "Bajraktari", "given": "Gani", "initials": "G", "orcid": "0000-0003-0410-968X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a2b0b473f4e471fb3443c28bf9002b9.json"}}, {"family": "Badano", "given": "Luigi Paolo", "initials": "LP"}, {"family": "Cameli", "given": "Matteo", "initials": "M", "orcid": "0000-0003-3872-8964", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e64899d051a84cd8a0cac5f503e03251.json"}}], "type": "journal article", "published": "2021-12-14", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "10", "issue": "24", "issn-l": "2077-0383"}, "abstract": "The COVID-19 pandemic carries a high burden of morbidity and mortality worldwide. We aimed to identify possible predictors of in-hospital major cardiovascular (CV) events in COVID-19.\n\nWe retrospectively included patients hospitalized for COVID-19 from 10 centers. Clinical, biochemical, electrocardiographic, and imaging data at admission and medications were collected. Primary endpoint was a composite of in-hospital CV death, acute heart failure (AHF), acute myocarditis, arrhythmias, acute coronary syndromes (ACS), cardiocirculatory arrest, and pulmonary embolism (PE).\n\nOf the 748 patients included, 141(19%) reached the set endpoint: 49 (7%) CV death, 15 (2%) acute myocarditis, 32 (4%) sustained-supraventricular or ventricular arrhythmias, 14 (2%) cardiocirculatory arrest, 8 (1%) ACS, 41 (5%) AHF, and 39 (5%) PE. Patients with CV events had higher age, body temperature, creatinine, high-sensitivity troponin, white blood cells, and platelet counts at admission and were more likely to have systemic hypertension, renal failure (creatinine \u2265 1.25 mg/dL), chronic obstructive pulmonary disease, atrial fibrillation, and cardiomyopathy. On univariate and multivariate analysis, troponin and renal failure were associated with the composite endpoint. Kaplan-Meier analysis showed a clear divergence of in-hospital composite event-free survival stratified according to median troponin value and the presence of renal failure (Log rank p < 0.001).\n\nOur findings, derived from a multicenter data collection study, suggest the routine use of biomarkers, such as cardiac troponin and serum creatinine, for in-hospital prediction of CV events in patients with COVID-19.", "doi": "10.3390/jcm10245863", "pmid": "34945166", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "jcm10245863"}, {"db": "pmc", "key": "PMC8703972"}], "notes": [], "created": "2022-01-04T15:32:03.472Z", "modified": "2022-01-04T15:32:03.918Z"}, {"entity": "publication", "iuid": "19cbe373455c4122b9b149c0f0f6afa6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19cbe373455c4122b9b149c0f0f6afa6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19cbe373455c4122b9b149c0f0f6afa6"}}, "title": "Sleep and daytime problems during the COVID-19 pandemic and effects of coronavirus infection, confinement and financial suffering: a multinational survey using a harmonised questionnaire.", "authors": [{"family": "Partinen", "given": "Markku", "initials": "M", "orcid": "0000-0002-8182-9368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7920bcc4716848f7bd1cb89c8bdd0d5a.json"}}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "Espie", "given": "Colin", "initials": "C"}, {"family": "Chung", "given": "Frances", "initials": "F", "orcid": "0000-0001-9576-3606", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed55f48b6d8e400b8fd2c591a738260a.json"}}, {"family": "Penzel", "given": "Thomas", "initials": "T", "orcid": "0000-0002-4304-0112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0dc4e472c71460ab792f74bc8163a9a.json"}}, {"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Bolstad", "given": "Courtney J", "initials": "CJ"}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J"}, {"family": "Chan", "given": "Rachel Ngan Yin", "initials": "RNY"}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L"}, {"family": "Han", "given": "Fang", "initials": "F"}, {"family": "Inoue", "given": "Yuichi", "initials": "Y"}, {"family": "Matsui", "given": "Kentaro", "initials": "K"}, {"family": "Leger", "given": "Damien", "initials": "D"}, {"family": "Cunha", "given": "Ana Suely", "initials": "AS"}, {"family": "Merikanto", "given": "Ilona", "initials": "I"}, {"family": "Mota-Rolim", "given": "Sergio", "initials": "S"}, {"family": "Nadorff", "given": "Michael", "initials": "M"}, {"family": "Plazzi", "given": "Giuseppe", "initials": "G"}, {"family": "Schneider", "given": "Jules", "initials": "J"}, {"family": "Sieminski", "given": "Mariusz", "initials": "M"}, {"family": "Wing", "given": "Yun-Kwok", "initials": "Y"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B", "orcid": "0000-0001-7051-745X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b72d97a35fa4590b5d05f0fd3524f2e.json"}}], "type": "journal article", "published": "2021-12-13", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "12", "pages": "e050672"}, "abstract": "Sleep is important for human health and well-being. No previous study has assessed whether the COVID-19 pandemic impacts sleep and daytime function across the globe.\r\n\r\nThis large-scale international survey used a harmonised questionnaire. Fourteen countries participated during the period of May-August 2020. Sleep and daytime problems (poor sleep quality, sleep onset and maintenance problems, nightmares, hypnotic use, fatigue and excessive sleepiness) occurring 'before' and 'during' the pandemic were investigated. In total, 25 484 people participated and 22 151 (86.9%) responded to the key parameters and were included. Effects of COVID-19, confinement and financial suffering were considered. In the fully adjusted logistic regression models, results (weighted and stratified by country) were adjusted for gender, age, marital status, educational level, ethnicity, presence of sleep problems before COVID-19 and severity of the COVID-19 pandemic in each country at the time of the survey.\r\n\r\nThe responders were mostly women (64%) with a mean age 41.8 (SD 15.9) years (median 39, range 18-95). Altogether, 3.0% reported having had COVID-19; 42.2% reported having been in confinement; and 55.9% had suffered financially. All sleep and daytime problems worsened during the pandemic by about 10% or more. Also, some participants reported improvements in sleep and daytime function. For example, sleep quality worsened in about 20% of subjects and improved in about 5%. COVID-19 was particularly associated with poor sleep quality, early morning awakening and daytime sleepiness. Confinement was associated with poor sleep quality, problems falling asleep and decreased use of hypnotics. Financial suffering was associated with all sleep and daytime problems, including nightmares and fatigue, even in the fully adjusted logistic regression models.\r\n\r\nSleep problems, fatigue and excessive sleepiness increased significantly worldwide during the first phase of the COVID-19 pandemic. Problems were associated with confinement and especially with financial suffering.", "doi": "10.1136/bmjopen-2021-050672", "pmid": "34903540", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-050672"}, {"db": "pmc", "key": "PMC8671846"}], "notes": [], "created": "2021-12-18T17:58:46.977Z", "modified": "2022-11-22T05:44:08.358Z"}, {"entity": "publication", "iuid": "6276d42a70524ee0bbfd239bccd5247a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6276d42a70524ee0bbfd239bccd5247a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6276d42a70524ee0bbfd239bccd5247a"}}, "title": "Pre-pandemic psychological and behavioral predictors of responses to the COVID-19 pandemic in nine countries.", "authors": [{"family": "Lansford", "given": "Jennifer E", "initials": "JE", "orcid": "0000-0003-1956-4917", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/099f957450e743acab538878cc487a27.json"}}, {"family": "Skinner", "given": "Ann T", "initials": "AT"}, {"family": "Godwin", "given": "Jennifer", "initials": "J"}, {"family": "Chang", "given": "Lei", "initials": "L"}, {"family": "Deater-Deckard", "given": "Kirby", "initials": "K"}, {"family": "Di Giunta", "given": "Laura", "initials": "L"}, {"family": "Dodge", "given": "Kenneth A", "initials": "KA"}, {"family": "Gurdal", "given": "Sevtap", "initials": "S"}, {"family": "Liu", "given": "Qin", "initials": "Q"}, {"family": "Long", "given": "Qian", "initials": "Q"}, {"family": "Oburu", "given": "Paul", "initials": "P"}, {"family": "Pastorelli", "given": "Concetta", "initials": "C"}, {"family": "Sorbring", "given": "Emma", "initials": "E"}, {"family": "Steinberg", "given": "Laurence", "initials": "L"}, {"family": "Tapanya", "given": "Sombat", "initials": "S"}, {"family": "Uribe Tirado", "given": "Liliana Maria", "initials": "LM"}, {"family": "Yotanyamaneewong", "given": "Saengduean", "initials": "S"}, {"family": "Alampay", "given": "Liane Pe\u00f1a", "initials": "LP"}, {"family": "Al-Hassan", "given": "Suha M", "initials": "SM"}, {"family": "Bacchini", "given": "Dario", "initials": "D"}, {"family": "Bornstein", "given": "Marc H", "initials": "MH"}], "type": "journal article", "published": "2021-12-13", "journal": {"title": "Dev Psychopathol", "issn": "1469-2198", "pages": "1-16", "issn-l": null}, "abstract": "Prior to the COVID-19 pandemic, adolescents (N = 1,330; Mages = 15 and 16; 50% female), mothers, and fathers from nine countries (China, Colombia, Italy, Jordan, Kenya, Philippines, Sweden, Thailand, United States) reported on adolescents' internalizing and externalizing problems, adolescents completed a lab-based task to assess tendency for risk-taking, and adolescents reported on their well-being. During the pandemic, participants (Mage = 20) reported on changes in their internalizing, externalizing, and substance use compared to before the pandemic. Across countries, adolescents' internalizing problems pre-pandemic predicted increased internalizing during the pandemic, and poorer well-being pre-pandemic predicted increased externalizing and substance use during the pandemic. Other relations varied across countries, and some were moderated by confidence in the government's handling of the pandemic, gender, and parents' education.", "doi": "10.1017/S0954579421001139", "pmid": "34895387", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0954579421001139"}], "notes": [], "created": "2021-12-18T18:03:30.717Z", "modified": "2021-12-18T18:03:30.766Z"}, {"entity": "publication", "iuid": "0e063f882a674f9f8044b640a8967486", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e063f882a674f9f8044b640a8967486.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e063f882a674f9f8044b640a8967486"}}, "title": "Omicron SARS-CoV-2 variant: Unique features and their impact on pre-existing antibodies.", "authors": [{"family": "Kannan", "given": "Saathvik R", "initials": "SR"}, {"family": "Spratt", "given": "Austin N", "initials": "AN"}, {"family": "Sharma", "given": "Kalicharan", "initials": "K"}, {"family": "Chand", "given": "Hitendra S", "initials": "HS"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}, {"family": "Singh", "given": "Kamal", "initials": "K"}], "type": "journal article", "published": "2021-12-13", "journal": {"title": "J Autoimmun", "issn": "1095-9157", "issn-l": null, "volume": "126", "issue": null, "pages": "102779"}, "abstract": "Severe Acute Respiratory Coronavirus (SARS-CoV-2) has been emerging in the form of different variants since its first emergence in early December 2019. A new Variant of Concern (VOC) named the Omicron variant (B.1.1.529) was reported recently. This variant has a large number of mutations in the S protein. To date, there exists a limited information on the Omicron variant. Here we present the analyses of mutation distribution, the evolutionary relationship of Omicron with previous variants, and probable structural impact of mutations on antibody binding. Our analyses show the presence of 46 high prevalence mutations specific to Omicron. Twenty-three of these are localized within the spike (S) protein and the rest localized to the other 3 structural proteins of the virus, the envelope (E), membrane (M), and nucleocapsid (N). Phylogenetic analysis showed that the Omicron is closely related to the Gamma (P.1) variant. The structural analyses showed that several mutations are localized to the region of the S protein that is the major target of antibodies, suggesting that the mutations in the Omicron variant may affect the binding affinities of antibodies to the S protein.", "doi": "10.1016/j.jaut.2021.102779", "pmid": "34915422", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Category: Omicron VoC": null}, "xrefs": [{"db": "pii", "key": "S0896-8411(21)00187-6"}], "notes": [], "created": "2021-12-18T17:45:00.563Z", "modified": "2022-01-12T20:58:21.050Z"}, {"entity": "publication", "iuid": "0aa5c8f8220e471593a756d4bc1b6241", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0aa5c8f8220e471593a756d4bc1b6241.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0aa5c8f8220e471593a756d4bc1b6241"}}, "title": "Emergence, evolution, and vaccine production approaches of SARS-CoV-2 virus: benefits of getting vaccinated and common questions.", "authors": [{"family": "Hassanin", "given": "Abdallah A", "initials": "AA"}, {"family": "Haidar Abbas Raza", "given": "Sayed", "initials": "S"}, {"family": "Ahmed Ujjan", "given": "Javed", "initials": "J"}, {"family": "Aysh ALrashidi", "given": "Ayshah", "initials": "A"}, {"family": "Sitohy", "given": "Basel M", "initials": "BM"}, {"family": "Al-Surhanee", "given": "Ameena A", "initials": "AA"}, {"family": "Saad", "given": "Ahmed M", "initials": "AM"}, {"family": "Mohamed Al-Hazani", "given": "Tahani", "initials": "T"}, {"family": "Osman Atallah", "given": "Osama", "initials": "O"}, {"family": "Al Syaad", "given": "Khalid M", "initials": "KM"}, {"family": "Ezzat Ahmed", "given": "Ahmed", "initials": "A"}, {"family": "Swelum", "given": "Ayman A", "initials": "AA"}, {"family": "El-Saadony", "given": "Mohamed T", "initials": "MT"}, {"family": "Sitohy", "given": "Mahmoud Z", "initials": "MZ"}], "type": "journal article", "published": "2021-12-13", "journal": {"title": "Saudi J Biol Sci", "issn": "1319-562X", "issn-l": null}, "abstract": "The emergence of coronavirus disease 2019 (COVID-19) pandemic in Wuhan city, China at the end of 2019 made it urgent to identify the origin of the causal pathogen and its molecular evolution, to appropriately design an effective vaccine. This study analyzes the evolutionary background of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or SARS-2) in accordance with its close relative SARS-CoV (SARS-1), which was emerged in 2002. A comparative genomic and proteomic study was conducted on SARS-2, SARS-1, and Middle East respiratory syndrome coronavirus (MERS), which was emerged in 2012. In silico analysis inferred the genetic variability among the tested viruses. The SARS-1 genome harbored 11 genes encoding 12 proteins, while SARS-2 genome contained only 10 genes encoding for 10 proteins. MERS genome contained 11 genes encoding 11 proteins. The analysis also revealed a slight variation in the whole genome size of SARS-2 comparing to its siblings resulting from sequential insertions and deletions (indels) throughout the viral genome particularly ORF1AB, spike, ORF10 and ORF8. The effective indels were observed in the gene encoding the spike protein that is responsible for viral attachment to the angiotensin-converting enzyme 2 (ACE2) cell receptor and initiating infection. These indels are responsible for the newly emerging COVID-19 variants \u03b1CoV, \u03b2CoV, \u03b3CoV and \u03b4CoV. Nowadays, few effective COVID-19 vaccines developed based on spike (S) glycoprotein were approved and become available worldwide. Currently available vaccines can relatively prevent the spread of COVID-19 and suppress the disease. The traditional (killed or attenuated virus vaccine and antibody-based vaccine) and innovated vaccine production technologies (RNA- and DNA-based vaccines and viral vectors) are summarized in this review. We finally highlight the most common questions related to COVID-19 disease and the benefits of getting vaccinated.", "doi": "10.1016/j.sjbs.2021.12.020", "pmid": "34924802", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1319-562X(21)01053-6"}, {"db": "pmc", "key": "PMC8667566"}], "notes": [], "created": "2022-01-03T15:21:37.660Z", "modified": "2022-01-03T15:21:51.284Z"}, {"entity": "publication", "iuid": "92a3a47c712744c8956a96910197caf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/92a3a47c712744c8956a96910197caf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/92a3a47c712744c8956a96910197caf3"}}, "title": "Clinical presentation and disease course in patients with flu-like illness: does microbiological aetiology matter?", "authors": [{"family": "Verheij", "given": "Theo", "initials": "T"}, {"family": "Cianci", "given": "Daniela", "initials": "D"}, {"family": "van der Velden", "given": "Alike", "initials": "A"}, {"family": "Butler", "given": "Christopher C", "initials": "CC"}, {"family": "Bongard", "given": "Emily", "initials": "E"}, {"family": "Coenen", "given": "Samuel", "initials": "S"}, {"family": "Colliers", "given": "Annelies", "initials": "A"}, {"family": "Francis", "given": "Nick", "initials": "N"}, {"family": "Little", "given": "Paul", "initials": "P"}, {"family": "Godycki-Cwirko", "given": "Maciek", "initials": "M"}, {"family": "Llor", "given": "Carl", "initials": "C"}, {"family": "Chlabicz", "given": "Slawomir", "initials": "S"}, {"family": "Lionis", "given": "Christos", "initials": "C"}, {"family": "Sundvall", "given": "P\u00e4r-Daniel", "initials": "PD"}, {"family": "Bjerrum", "given": "Lars", "initials": "L"}, {"family": "De Sutter", "given": "An", "initials": "A"}, {"family": "Aabenhus", "given": "Rune", "initials": "R"}, {"family": "Jonassen Harbin", "given": "Nicolay", "initials": "N"}, {"family": "Lindbaek", "given": "Morten", "initials": "M"}, {"family": "Glinz", "given": "Dominik", "initials": "D"}, {"family": "Bucher", "given": "Heiner", "initials": "H"}, {"family": "Kovacs", "given": "Bernadett", "initials": "B"}, {"family": "Seifert", "given": "Bohumil", "initials": "B"}, {"family": "Touboul Lundgren", "given": "Pia", "initials": "P"}, {"family": "de Paor", "given": "Muireann", "initials": "M"}, {"family": "Radzeviciene JUrgute", "given": "Ruta", "initials": "R"}, {"family": "Matheeussen", "given": "Veerle", "initials": "V"}, {"family": "Goossens", "given": "Herman", "initials": "H"}, {"family": "Ieven", "given": "Margareta", "initials": "M"}], "type": "journal article", "published": "2021-12-13", "journal": {"title": "Br J Gen Pract", "issn": "1478-5242", "issn-l": null}, "abstract": "There is little evidence about the relation between aetiology, illness severity and clinical course of respiratory tract infections (RTI) in primary care. Understanding these associations would aid to develop effective management strategies for these infections.\n\nTo investigate whether the clinical presentation and illness course differ between RTI in whom a viral pathogen was detected and those in whom a potential bacterial pathogen was found.\n\nPost hoc analysis of data from a pragmatic randomised trial on the effects of oseltamivir in patients with influenza-like illness (ILI) in primary care (n=3266) in 15 European countries.\n\nPatient characteristics, signs and symptoms were registered at baseline. Naso-pharyngeal (adults) or nasal and pharyngeal (children) swabs were taken for PCR analysis. Patients were followed up until 28 days after inclusion. Regression models and Kaplan-Meier curves were used to analyse the relation between aetiology, clinical presentation at baseline and course of disease including complications.\n\nExcept for a less prominent congested nose (OR 0.55, CI 0.35 - 0.86) and acute cough (OR 0.52, CI 0.27 - 0.65) in ILI patients in whom a possible bacterial pathogen was isolated, there were no clear clinical differences in presentations between those with a possible bacterial aetiology than in those with a viral one. Also the course of disease and complications were not related to aetiology.\n\nGiven the currently available microbiological tests and antimicrobial treatments, and outside pandemics like COVID-19, microbiological testing in primary care patients with ILI seems to have limited value.", "doi": "10.3399/BJGP.2021.0344", "pmid": "34990385", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "BJGP.2021.0344"}], "notes": [], "created": "2022-01-10T15:32:25.010Z", "modified": "2022-01-10T15:33:16.872Z"}, {"entity": "publication", "iuid": "8a4515a6f1e84870b7936c53b3260746", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a4515a6f1e84870b7936c53b3260746.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a4515a6f1e84870b7936c53b3260746"}}, "title": "COVID-19 pandemic and the great impulse to telemedicine: the basis of the WONCA Europe Statement on Telemedicine at the WHO Europe 70th Regional Meeting September 2020.", "authors": [{"family": "Petrazzuoli", "given": "Ferdinando", "initials": "F", "orcid": "0000-0003-1058-492X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50bb7fdd235f46629be48fdff0a5fd6c.json"}}, {"family": "Kurpas", "given": "Donata", "initials": "D"}, {"family": "Vinker", "given": "Shlomo", "initials": "S"}, {"family": "Sarkisova", "given": "Valentina", "initials": "V"}, {"family": "Eleftheriou", "given": "Androulla", "initials": "A"}, {"family": "\u017bakowicz", "given": "Anna", "initials": "A", "orcid": "0000-0001-9658-8918", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/047c309284f143e8a5fd0e1103a53a1b.json"}}, {"family": "Aarendonk", "given": "Diederik", "initials": "D", "orcid": "0000-0002-8973-5446", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f2df4a7937fa4833a73389b2a420a730.json"}}, {"family": "Ungan", "given": "Mehmet", "initials": "M", "orcid": "0000-0002-6078-2177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5017979702474b50820ef5d65bb10433.json"}}], "type": "journal article", "published": "2021-12-13", "journal": {"title": "Prim Health Care Res Dev", "issn": "1477-1128", "volume": "22", "pages": "e80", "issn-l": null}, "abstract": "Telemedicine is the use of telecommunication and information technologies to support the delivery of healthcare at a distance, guaranteeing patients healthcare by facilitating access where barriers exist; the COVID-19 pandemic has attracted worldwide interest in this field.The purpose of this paper is to highlight the main pros and cons of telemedicine, which serve as the basis of the WONCA Europe Statement at the WHO Europe 70th Regional Meeting on 14 September 2020.Pros of telemedicine include virtual healthcare at home, where patients receive support in certain conditions without leaving their houses. During a pandemic, it can be adopted to limit physical human interaction. Unfortunately, it can negatively affect the quality of the doctor-patient relationship, the quality of the physical examination, and the quality of care. Telemedicine requires effective infrastructure and robust investments to be feasible and effective.", "doi": "10.1017/S1463423621000633", "pmid": "34895388", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1463423621000633"}], "notes": [], "created": "2021-12-18T18:03:07.295Z", "modified": "2021-12-18T18:03:07.462Z"}, {"entity": "publication", "iuid": "15e8d389e07a4f74905c650a0fbe6b30", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15e8d389e07a4f74905c650a0fbe6b30.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15e8d389e07a4f74905c650a0fbe6b30"}}, "title": "Mental health indicators in Sweden over a 12-month period during the COVID-19 pandemic", "authors": [{"family": "Lovik", "given": "Anik\u00f3", "initials": "A", "orcid": "0000-0002-6397-5011", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e50d5a79a1234cd79b22ec2eebf6f410.json"}}, {"family": "Gonz\u00e1lez-Hij\u00f3n", "given": "Juan", "initials": "J", "orcid": "0000-0002-3354-6697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/035df95b22194d599ab916c363018cb0.json"}}, {"family": "K\u00e4hler", "given": "Anna K", "initials": "AK", "orcid": "0000-0003-4047-4588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6d52ec01645417eb73e2bfe6c3106bd.json"}}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA", "orcid": "0000-0001-5382-946X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87d1dbec7c6f4942b1db2b999eeb9ece.json"}}, {"family": "Frans", "given": "Emma M", "initials": "EM", "orcid": "0000-0002-9791-687X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/157f412416124221ab8387bfaee3b75b.json"}}, {"family": "Magnusson", "given": "Patrik K E", "initials": "PKE"}, {"family": "Pedersen", "given": "Nancy L", "initials": "NL", "orcid": "0000-0001-8057-3543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d52d7b52d5d44febc084912148555d2.json"}}, {"family": "Hall", "given": "Per", "initials": "P", "orcid": "0000-0002-5640-9126", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36cad09fa55242b38353f6cc9081e65d.json"}}, {"family": "Czene", "given": "Kamila", "initials": "K", "orcid": "0000-0002-3233-5695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43c2cbe995a64134bc53e1c57800d798.json"}}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF", "orcid": "0000-0002-6619-873X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f9632d685f348cea7a69ebfe51ad0ab.json"}}, {"family": "Fang", "given": "Fang", "initials": "F", "orcid": "0000-0002-3310-6456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b0852465cd14239a25329b976172792.json"}}], "type": "posted-content", "published": "2021-12-11", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.12.10.21267338", "pmid": null, "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Preprint": null, "Funder: NordForsk": null}, "xrefs": [], "notes": [], "created": "2023-02-13T18:39:39.428Z", "modified": "2023-10-04T08:18:19.334Z"}, {"entity": "publication", "iuid": "6b238744a79b413380ea8cb666d8ea3e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b238744a79b413380ea8cb666d8ea3e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b238744a79b413380ea8cb666d8ea3e"}}, "title": "Immunogenicity after six months of BNT162b2 vaccination in frail or disabled nursing home residents: the COVID\u2010A Study", "authors": [{"family": "R\u00edos", "given": "Sergio Salmer\u00f3n", "initials": "SS"}, {"family": "Zamora", "given": "Elisa Bel\u00e9n Cort\u00e9s", "initials": "EBC"}, {"family": "C\u00e9spedes", "given": "Almudena Avenda\u00f1o", "initials": "AA"}, {"family": "Rizos", "given": "Luis Romero", "initials": "LR"}, {"family": "S\u00e1nchez\u2010Jurado", "given": "Pedro Manuel", "initials": "PM"}, {"family": "S\u00e1nchez\u2010Nievas", "given": "Gin\u00e9s", "initials": "G"}, {"family": "Romero", "given": "Marta Mas", "initials": "MM"}, {"family": "Tabernero Sahuquillo", "given": "Mar\u00eda Teresa", "initials": "MT"}, {"family": "Se\u00f1alada", "given": "Jos\u00e9 Joaqu\u00edn Blas", "initials": "JJB"}, {"family": "Romero", "given": "Antonio Murillo", "initials": "AM"}, {"family": "Nogueras", "given": "Inmaculada Garc\u00eda", "initials": "IG"}, {"family": "Dios Estrella Cazalla", "given": "Juan", "initials": "J"}, {"family": "Andr\u00e9s\u2010Pretel", "given": "Fernando", "initials": "F"}, {"family": "Lauschke", "given": "Volker Martin", "initials": "VM"}, {"family": "Stebbing", "given": "Justin", "initials": "J"}, {"family": "Abizanda", "given": "Pedro", "initials": "P", "orcid": "0000-0002-4707-2963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed9e8a3fed5842cd9ad7d5653b85c4a1.json"}}], "type": "journal-article", "published": "2021-12-11", "journal": {"title": "J Am Geriatr Soc", "issn": "0002-8614", "issn-l": null}, "abstract": null, "doi": "10.1111/jgs.17620", "pmid": null, "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:45:43.140Z", "modified": "2021-12-12T06:45:43.166Z"}, {"entity": "publication", "iuid": "ce55eff25b8f4e148e130386faafb114", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ce55eff25b8f4e148e130386faafb114.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ce55eff25b8f4e148e130386faafb114"}}, "title": "The profile of the COvid-19 VACcination register SAFEty study in Sweden (CoVacSafe-SE).", "authors": [{"family": "Ljung", "given": "Rickard", "initials": "R"}, {"family": "Sundstr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Gr\u00fcnewald", "given": "Maria", "initials": "M"}, {"family": "Backman", "given": "Charlotte", "initials": "C"}, {"family": "Feltelius", "given": "Nils", "initials": "N"}, {"family": "Gedeborg", "given": "Rolf", "initials": "R"}, {"family": "Zethelius", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2021-12-10", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "volume": "126", "issn-l": "0300-9734"}, "abstract": "The coronavirus disease 2019 (COVID-19) vaccines have been rapidly implemented in national vaccination programs world-wide after accelerated approval processes. The large population exposure achieved in very short time requires systematic monitoring of safety. The Swedish Medical Products Agency has launched a project platform for epidemiological surveillance to detect and characterise suspected adverse effects of COVID-19 vaccines in Sweden.\n\nThe platform includes all individuals 12 years or older in Sweden in 2021 and will be updated annually. Data, including vaccine and COVID-19 disease data, socioeconomic and demographic data, comorbidity, prescribed medicines and healthcare utilisation outcomes, are obtained from several national registers in collaboration with other Swedish Government agencies. Data from 2015 to 2019 are used as a historical comparison cohort unexposed to both the COVID-19 pandemic and to the COVID-19 vaccines.\n\nThe primary study cohort includes 8,305,978 adults 18 years and older permanently residing in Sweden on 31 December 2020. The historical control cohort includes 8,679,641 subjects. By 31 July 2021, around 50% of those 18 years and older and two-thirds of those 50 years and older were vaccinated with at least one dose, 90% of those 70 years or older had two doses.\n\nThe nationwide register-based study cohort created by the Swedish Medical Products Agency with regular updates of individual level linkage of COVID-19 vaccination exposure data to other health data registers will facilitate both safety signal detection and evaluation and other pharmacoepidemiological studies.", "doi": "10.48101/ujms.v126.8136", "pmid": "34984096", "labels": {"Category: Vaccines": null, "Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC8693580"}, {"db": "pii", "key": "8136"}], "notes": [], "created": "2022-01-10T15:34:26.263Z", "modified": "2023-01-13T13:39:24.450Z"}, {"entity": "publication", "iuid": "e629e0b88f764cb6a5e5e0616bead01b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e629e0b88f764cb6a5e5e0616bead01b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e629e0b88f764cb6a5e5e0616bead01b"}}, "title": "Safeguarding people living in vulnerable conditions in the COVID-19 era through universal health coverage and social protection.", "authors": [{"family": "Barron", "given": "Gabriela Cuevas", "initials": "GC"}, {"family": "Laryea-Adjei", "given": "George", "initials": "G"}, {"family": "Vike-Freiberga", "given": "Vaira", "initials": "V"}, {"family": "Abubakar", "given": "Ibrahim", "initials": "I"}, {"family": "Dakkak", "given": "Henia", "initials": "H"}, {"family": "Devakumar", "given": "Delanjathan", "initials": "D"}, {"family": "Johnsson", "given": "Anders", "initials": "A"}, {"family": "Karabey", "given": "Selma", "initials": "S"}, {"family": "Labont\u00e9", "given": "Ronald", "initials": "R"}, {"family": "Legido-Quigley", "given": "Helena", "initials": "H"}, {"family": "Lloyd-Sherlock", "given": "Peter", "initials": "P"}, {"family": "Olufadewa", "given": "Isaac Iyinoluwa", "initials": "II"}, {"family": "Ray", "given": "Harold Calvin", "initials": "HC"}, {"family": "Redlener", "given": "Irwin", "initials": "I"}, {"family": "Redlener", "given": "Karen", "initials": "K"}, {"family": "Serageldin", "given": "Ismail", "initials": "I"}, {"family": "Lima", "given": "Nisia Trindade", "initials": "NT"}, {"family": "Viana", "given": "Virgilio", "initials": "V"}, {"family": "Zappone", "given": "Katherine", "initials": "K"}, {"family": "Huynh", "given": "Uyen Kim", "initials": "UK"}, {"family": "Schlosberg", "given": "Nicole", "initials": "N"}, {"family": "Sun", "given": "Hanlu", "initials": "H"}, {"family": "Karadag", "given": "Ozge", "initials": "O"}, {"family": "Lancet Commission on COVID-19: Task Force on Humanitarian Relief, Social Protection and Vulnerable Groups", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-10", "journal": {"title": "Lancet Public Health", "issn": "2468-2667", "issn-l": null}, "abstract": "The COVID-19 pandemic is unprecedented. The pandemic not only induced a public health crisis, but has led to severe economic, social, and educational crises. Across economies and societies, the distributional consequences of the pandemic have been uneven. Among groups living in vulnerable conditions, the pandemic substantially magnified the inequality gaps, with possible negative implications for these individuals' long-term physical, socioeconomic, and mental wellbeing. This Viewpoint proposes priority, programmatic, and policy recommendations that governments, resource partners, and relevant stakeholders should consider in formulating medium-term to long-term strategies for preventing the spread of COVID-19, addressing the virus's impacts, and decreasing health inequalities. The world is at a never more crucial moment, requiring collaboration and cooperation from all sectors to mitigate the inequality gaps and improve people's health and wellbeing with universal health coverage and social protection, in addition to implementation of the health in all policies approach.", "doi": "10.1016/S2468-2667(21)00235-8", "pmid": "34906331", "labels": {"Type: Review": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2468-2667(21)00235-8"}, {"db": "pmc", "key": "PMC8665842"}], "notes": [], "created": "2021-12-18T17:54:05.429Z", "modified": "2021-12-18T17:54:05.441Z"}, {"entity": "publication", "iuid": "57212c7f13c042b986a0532a73c0e0c1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/57212c7f13c042b986a0532a73c0e0c1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/57212c7f13c042b986a0532a73c0e0c1"}}, "title": "Infectious complications and vaccines", "authors": [{"family": "Ljungman", "given": "Per", "initials": "P"}], "type": "journal-article", "published": "2021-12-10", "journal": {"issn": "1520-4391", "volume": "2021", "issue": "1", "pages": "587-591", "issn-l": null}, "abstract": null, "doi": "10.1182/hematology.2021000294", "pmid": null, "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:51:52.783Z", "modified": "2021-12-12T06:51:52.898Z"}, {"entity": "publication", "iuid": "0a34a24ce00441bc96f56bc382e194e3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a34a24ce00441bc96f56bc382e194e3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a34a24ce00441bc96f56bc382e194e3"}}, "title": "The Depression: Online Therapy Study (D:OTS)-A Pilot Study of an Internet-Based Psychodynamic Treatment for Adolescents with Low Mood in the UK, in the Context of the COVID-19 Pandemic.", "authors": [{"family": "Midgley", "given": "Nick", "initials": "N"}, {"family": "Guerrero-Tates", "given": "Brenda", "initials": "B", "orcid": "0000-0001-6329-7444", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b32ab4ed632f47f9863ccc50421e02c1.json"}}, {"family": "Mortimer", "given": "Rose", "initials": "R"}, {"family": "Edbrooke-Childs", "given": "Julian", "initials": "J"}, {"family": "Mechler", "given": "Jakob", "initials": "J", "orcid": "0000-0002-1296-3432", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69054a3745b04d12b759a754b88148c7.json"}}, {"family": "Lindqvist", "given": "Karin", "initials": "K"}, {"family": "Hajkowski", "given": "Susan", "initials": "S"}, {"family": "Leibovich", "given": "Liat", "initials": "L"}, {"family": "Martin", "given": "Peter", "initials": "P", "orcid": "0000-0003-4638-0638", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f85a19380ba34972a839e5453514ae65.json"}}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Vlaescu", "given": "George", "initials": "G"}, {"family": "Lilliengren", "given": "Peter", "initials": "P"}, {"family": "Kitson", "given": "Annabel", "initials": "A"}, {"family": "Butler-Wheelhouse", "given": "Pamela", "initials": "P"}, {"family": "Philips", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2021-12-09", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "24", "issn-l": null}, "abstract": "Introduction: Face-to-face therapy is unavailable to many young people with mental health difficulties in the UK. Internet-based treatments are a low-cost, flexible, and accessible option that may be acceptable to young people. This pilot study examined the feasibility, acceptability and effectiveness of an English-language adaptation of internet-based psychodynamic treatment (iPDT) for depressed adolescents, undertaken during the COVID-19 pandemic in the UK. Methods: A single-group, uncontrolled design was used. A total of 23 adolescents, 16-18 years old and experiencing depression, were recruited to this study. Assessments were made at baseline and end of treatment, with additional weekly assessments of depression and anxiety symptoms. Results: Findings showed that it was feasible to recruit to this study during the pandemic, and to deliver the iPDT model with a good level of treatment acceptability. A statistically significant reduction in depressive symptoms and emotion dysregulation was found, with large effect size, by the end of treatment. Whilst anxiety symptoms decreased, this did not reach statistical significance. Conclusions: The findings suggest that this English-language adaptation of iPDT, with some further revisions, is feasible to deliver and acceptable for adolescents with depression. Preliminary data indicate that iPDT appears to be effective in reducing depressive symptoms in adolescents.", "doi": "10.3390/ijerph182412993", "pmid": "34948601", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182412993"}, {"db": "pmc", "key": "PMC8702018"}], "notes": [], "created": "2022-01-04T15:31:18.484Z", "modified": "2022-01-04T15:31:26.495Z"}, {"entity": "publication", "iuid": "75c2e73874374773acdbf004d6dba2a8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/75c2e73874374773acdbf004d6dba2a8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/75c2e73874374773acdbf004d6dba2a8"}}, "title": "Surveillance of COVID-19 vaccine effectiveness \u2013 a real-time case-control study in southern Sweden", "authors": [{"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J", "orcid": "0000-0003-1883-2000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e88fdca336ae41c891f0a46e2481b67f.json"}}, {"family": "Bonander", "given": "Carl", "initials": "C", "orcid": "0000-0002-1189-9950", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/386ac82b1a4843828b503ec807c08206.json"}}, {"family": "Moghaddassi", "given": "Mahnaz", "initials": "M", "orcid": "0000-0002-0844-4736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a219bde5ba8a4f3f8655ada08d749885.json"}}, {"family": "Rasmussen", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1588-5473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c760e8d21ae441ba236f86e6185d392.json"}}, {"family": "Malmqvist", "given": "Ulf", "initials": "U"}, {"family": "Kahn", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-5566-6350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42eda71f3775400599febc10a4e7359c.json"}}, {"family": "Inghammar", "given": "Malin", "initials": "M", "orcid": "0000-0003-2995-1312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4ab710428614cccb2a537ecab31d0a0.json"}}], "type": "posted-content", "published": "2021-12-09", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.12.09.21267515", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:47:57.738Z", "modified": "2022-01-04T15:47:57.811Z"}, {"entity": "publication", "iuid": "2c51df9483e84e5582c25da75f2caf02", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c51df9483e84e5582c25da75f2caf02.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c51df9483e84e5582c25da75f2caf02"}}, "title": "Indirect effects of COVID-19 on the environment: How deep and how long?", "authors": [{"family": "Vadiati", "given": "Meysam", "initials": "M"}, {"family": "Beynaghi", "given": "Ali", "initials": "A"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Bandala", "given": "Erick R", "initials": "ER"}, {"family": "Mozafari", "given": "Masoud", "initials": "M"}], "type": "journal article", "published": "2021-12-09", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "pages": "152255", "issn-l": "0048-9697"}, "abstract": "Although the World Health Organization (WHO) announcement released in early March 2020 stated there is no proven evidence that the COVID-19 virus can survive in drinking water or sewage, there has been some recent evidence that coronaviruses can survive in low-temperature environments and in groundwater for more than a week. Some studies have also found SARS-CoV-2 genetic materials in raw municipal wastewater, which highlights a potential avenue for viral spread. A lack of information about the presence and spread of COVID-19 in the environment may lead to decisions based on local concerns and prevent the integration of the prevalence of SARS-CoV-2 into the global water cycle. Several studies have optimistically assumed that coronavirus has not yet affected water ecosystems, but this assumption may increase the possibility of subsequent global water issues. More studies are needed to provide a comprehensive picture of COVID-19 occurrence and outbreak in aquatic environments and more specifically in water resources. As scientific efforts to report reliable news, conduct rapid and precise research on COVID-19, and advocate for scientists worldwide to overcome this crisis increase, more information is required to assess the extent of the effects of the COVID-19 pandemic on the environment. The goals of this study are to estimate the extent of the environmental effects of the pandemic, as well as identify related knowledge gaps and avenues for future research.", "doi": "10.1016/j.scitotenv.2021.152255", "pmid": "34896489", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(21)07331-9"}, {"db": "pmc", "key": "PMC8660132"}], "notes": [], "created": "2021-12-18T18:02:36.372Z", "modified": "2021-12-18T18:02:36.384Z"}, {"entity": "publication", "iuid": "9f7d2dc2f2ba4d5f814c6b9181f721b6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f7d2dc2f2ba4d5f814c6b9181f721b6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f7d2dc2f2ba4d5f814c6b9181f721b6"}}, "title": "Increasing risk of breakthrough COVID-19 in outbreaks with high attack rates in European long-term care facilities, July to October 2021", "authors": [{"family": "Suetens", "given": "Carl", "initials": "C"}, {"family": "Kinross", "given": "Pete", "initials": "P"}, {"family": "Gallego Berciano", "given": "Pilar", "initials": "P"}, {"family": "Arroyo Nebreda", "given": "Virginia", "initials": "V"}, {"family": "Hassan", "given": "Eline", "initials": "E"}, {"family": "Calba", "given": "Cl\u00e9mentine", "initials": "C"}, {"family": "Fernandes", "given": "Eugenia", "initials": "E"}, {"family": "Peralta-Santos", "given": "Andre", "initials": "A"}, {"family": "Casaca", "given": "Pedro", "initials": "P"}, {"family": "Shodu", "given": "Nathalie", "initials": "N"}, {"family": "Dequeker", "given": "Sara", "initials": "S"}, {"family": "Kontopidou", "given": "Flora", "initials": "F"}, {"family": "Pappa", "given": "Lamprini", "initials": "L"}, {"family": "Kacelnik", "given": "Oliver", "initials": "O"}, {"family": "B\u00f8rseth", "given": "Anita Wang", "initials": "AW"}, {"family": "O\u2019Connor", "given": "Lois", "initials": "L"}, {"family": "Garvey", "given": "Patricia", "initials": "P"}, {"family": "Liausedien\u0117", "given": "Rasa", "initials": "R"}, {"family": "Valintelien\u0117", "given": "Rolanda", "initials": "R"}, {"family": "Ernst", "given": "Corinna", "initials": "C"}, {"family": "Mossong", "given": "Jo\u00ebl", "initials": "J"}, {"family": "\u0160tefkovi\u010dov\u00e1", "given": "M\u00e1ria", "initials": "M"}, {"family": "Prostin\u00e1kov\u00e1", "given": "Zuzana", "initials": "Z"}, {"family": "Danielsen", "given": "Ann Caroline", "initials": "AC"}, {"family": "Mougkou", "given": "Aikaterini", "initials": "A"}, {"family": "Lamb", "given": "Favelle", "initials": "F"}, {"family": "Cenciarelli", "given": "Orlando", "initials": "O"}, {"family": "Monnet", "given": "Dominique L", "initials": "DL"}, {"family": "Plachouras", "given": "Diamantis", "initials": "D"}], "type": "journal-article", "published": "2021-12-09", "journal": {"issn": "1560-7917", "volume": "26", "issue": "49", "title": "Euro Surveill", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.es.2021.26.49.2101070", "pmid": null, "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:55:12.065Z", "modified": "2021-12-12T06:55:12.078Z"}, {"entity": "publication", "iuid": "50574c4460054f4bac0c05e7f605b4f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50574c4460054f4bac0c05e7f605b4f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50574c4460054f4bac0c05e7f605b4f7"}}, "title": "Autoantibodies and infection with SARS-CoV2 infection: The spectrum from association to clinical implicationreport of the 15th Dresden symposium on autoantibodies.", "authors": [{"family": "Damoiseaux", "given": "Jan", "initials": "J"}, {"family": "Dotan", "given": "Arad", "initials": "A"}, {"family": "Fritzler", "given": "Marvin J", "initials": "MJ"}, {"family": "Bogdanos", "given": "Dimitrios P", "initials": "DP"}, {"family": "Meroni", "given": "Pier Luigi", "initials": "PL"}, {"family": "Roggenbuck", "given": "Dirk", "initials": "D"}, {"family": "Goldman", "given": "Michel", "initials": "M"}, {"family": "Landegren", "given": "Nils", "initials": "N"}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Shoenfeld", "given": "Yehuda", "initials": "Y"}, {"family": "Conrad", "given": "Karsten", "initials": "K"}], "type": "journal article", "published": "2021-12-09", "journal": {"title": "Autoimmun Rev", "issn": "1873-0183", "pages": "103012", "issn-l": null}, "abstract": "The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Symposium on Autoantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting.", "doi": "10.1016/j.autrev.2021.103012", "pmid": "34896650", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1568-9972(21)00294-9"}, {"db": "pmc", "key": "PMC8656211"}], "notes": [], "created": "2021-12-18T18:01:27.322Z", "modified": "2021-12-18T18:01:36.807Z"}, {"entity": "publication", "iuid": "ea1e1a34cf7d4dabbd5a5918e7571cbd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ea1e1a34cf7d4dabbd5a5918e7571cbd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ea1e1a34cf7d4dabbd5a5918e7571cbd"}}, "title": "Convalescent plasma treatment in severely immunosuppressed patients hospitalized with COVID-19: an observational study of 28 cases.", "authors": [{"family": "Ljungquist", "given": "Oskar", "initials": "O"}, {"family": "Lundgren", "given": "Maria", "initials": "M"}, {"family": "Iliachenko", "given": "Elena", "initials": "E"}, {"family": "M\u00e5nsson", "given": "Fredrik", "initials": "F"}, {"family": "B\u00f6ttiger", "given": "Blenda", "initials": "B"}, {"family": "Landin-Olsson", "given": "Mona", "initials": "M"}, {"family": "Wik\u00e9n", "given": "Christian", "initials": "C"}, {"family": "Rosendal", "given": "Ebba", "initials": "E"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "Wigren", "given": "Bystr\u00f6m J", "initials": "BJ"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Kjeldsen-Kragh", "given": "Jens", "initials": "J"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1588-5473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c760e8d21ae441ba236f86e6185d392.json"}}, {"family": "Kahn", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-5566-6350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42eda71f3775400599febc10a4e7359c.json"}}, {"family": "Holm", "given": "Karin", "initials": "K", "orcid": "0000-0002-8289-5949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7f590df41084ab28d7a1ac80b1b90e7.json"}}], "type": "journal article", "published": "2021-12-08", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "pages": "1-9", "issn-l": "2374-4235"}, "abstract": "Immunosuppressed patients are particularly vulnerable to severe infection from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), risking prolonged viremia and symptom duration. In this study we describe clinical and virological treatment outcomes in a heterogeneous group of patients with severe immunosuppression due to various causes suffering from COVID-19 infection, who were all treated with convalescent plasma (CCP) along with standard treatment.\n\nWe performed an observational, retrospective case series between May 2020 to March 2021 at three sites in Sk\u00e5ne, Sweden, with a population of nearly 1.4 million people. All patients hospitalized for COVID-19 who received CCP with the indication severe immunosuppression as defined by the treating physician were included in the study (n = 28).\n\nIn total, 28 severely immunocompromised patients, half of which previously had been treated with rituximab, who had received in-hospital convalescent plasma treatment of COVID-19 were identified. One week after CCP treatment, 13 of 28 (46%) patients had improved clinically defined as a decrease of at least one point at the WHO-scale. Three patients had increased score points of whom two had died. For 12 patients, the WHO-scale was unchanged.\n\nAs one of only few studies on CCP treatment of COVID-19 in hospitalized patients with severe immunosuppression, this study adds descriptive data. The study design prohibits conclusions on safety and efficacy, and the results should be interpreted with caution. Prospective, randomized trials are needed to investigate this further.", "doi": "10.1080/23744235.2021.2013528", "pmid": "34878955", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-12T07:15:43.946Z", "modified": "2021-12-12T07:15:44.023Z"}, {"entity": "publication", "iuid": "cc31f7e80cd84d1eb9ef8e03aa706616", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc31f7e80cd84d1eb9ef8e03aa706616.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc31f7e80cd84d1eb9ef8e03aa706616"}}, "title": "What a Pandemic Has Taught Us About the Potential for Innovation in Rural Health: Commencing an Ethnography in Canada, the United States, Sweden, and Australia.", "authors": [{"family": "Petrie", "given": "Samuel", "initials": "S"}, {"family": "Carson", "given": "Dean", "initials": "D"}, {"family": "Peters", "given": "Paul", "initials": "P"}, {"family": "Hurtig", "given": "Anna-Karin", "initials": "AK"}, {"family": "LeBlanc", "given": "Michele", "initials": "M"}, {"family": "Simpson", "given": "Holly", "initials": "H"}, {"family": "Barnabe", "given": "Jaymie", "initials": "J"}, {"family": "Young", "given": "Mikayla", "initials": "M"}, {"family": "Ostafichuk", "given": "Mara", "initials": "M"}, {"family": "Hodge", "given": "Heidi", "initials": "H"}, {"family": "Gladman", "given": "Justin", "initials": "J"}, {"family": "Smale", "given": "Matilda", "initials": "M"}, {"family": "Gonzalez Garcia", "given": "Manueal", "initials": "M"}], "type": "journal article", "published": "2021-12-07", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "768624", "issn-l": "2296-2565"}, "abstract": "The COVID-19 pandemic coincided with a multi-national federally funded research project examining the potential for health and care services in small rural areas to identify and implement innovations in service delivery. The project has a strong focus on electronic health (eHealth) but covers other areas of innovation as well. The project has been designed as an ethnography to prelude a realist evaluation, asking the question under what conditions can local health and care services take responsibility for designing and implementing new service models that meet local needs? The project had already engaged with several health care practitioners and research students based in Canada, Sweden, Australia, and the United States. Our attention is particularly on rural communities with fewer than 5,000 residents and which are relatively isolated from larger service centres. Between March and September 2020, the project team undertook ethnographic and auto-ethnographic research in their own communities to investigate what the service model responses to the pandemic were, and the extent to which local service managers were able to customize their responses to suit the needs of their communities. An initial program theory drawn from the extant literature suggested that \"successful\" response to the pandemic would depend on a level of local autonomy, \"absorptive capacity,*\" strong service-community connections, an \"anti-fragile\u2020\" approach to implementing change, and a realistic recognition of the historical barriers to implementing eHealth and other innovations in these types of rural communities. The field research in 2020 has refined the theory by focusing even more attention on absorptive capacity and community connections, and by suggesting that some level of ignorance of the barriers to innovation may be beneficial. The research also emphasized the role and power of external actors to the community which had not been well-explored in the literature. This paper will summarize both what the field research revealed about the capacity to respond well to the COVID-19 challenge and highlight the gaps in innovative strategies at a managerial level required for rapid response to system stress. *Absorptive Capacity is defined as the ability of an organization (community, clinic, hospital) to adapt to change. Organizations with flexible capacity can incorporate change in a productive fashion, while those with rigid capacity take longer to adapt, and may do so inappropriately. \u2020Antifragility is defined as an entities' ability to gain stability through stress. Biological examples include building muscle through consistent use, and bones becoming stronger through subtle stress. Antifragility has been used as a guiding principle in programme implementation in the past.", "doi": "10.3389/fpubh.2021.768624", "pmid": "34950628", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8688687"}], "notes": [], "created": "2022-01-04T15:27:50.199Z", "modified": "2022-01-04T15:27:50.212Z"}, {"entity": "publication", "iuid": "052ca3e645354ab7a97015a64dd0b35e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/052ca3e645354ab7a97015a64dd0b35e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/052ca3e645354ab7a97015a64dd0b35e"}}, "title": "Training the trainers: Finding new educational opportunities in the virtual world.", "authors": [{"family": "Baessler", "given": "Franziska", "initials": "F", "orcid": "0000-0001-7280-9675", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8397969848e4bbf90e3b54df39bdb1b.json"}}, {"family": "Sartorius", "given": "Norman", "initials": "N", "orcid": "0000-0001-8708-6289", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04897447954f4336ae2d7f094bbc4571.json"}}, {"family": "Javed", "given": "Afzal", "initials": "A", "orcid": "0000-0003-2518-0688", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c17ce249596343c78ae97f5a7c68c916.json"}}, {"family": "Tasman", "given": "Allan", "initials": "A"}, {"family": "Coskun", "given": "Bulent", "initials": "B", "orcid": "0000-0002-6381-8120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba8f859894574029adfc05e94b15f5f5.json"}}, {"family": "Frydecka", "given": "Dorota", "initials": "D", "orcid": "0000-0001-8582-9958", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd965f723ffb48b283e8e318b6baba75.json"}}, {"family": "Kazakova", "given": "Olga", "initials": "O", "orcid": "0000-0003-3261-3429", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8434c5d25ce64f048f4b8b56b2ec3a9d.json"}}, {"family": "Sampogna", "given": "Gaia", "initials": "G", "orcid": "0000-0002-9547-2793", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8aa29f1af234c24b093c46f4cad7a22.json"}}, {"family": "Zhabenko", "given": "Olena", "initials": "O", "orcid": "0000-0001-7986-2970", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e133dad8f94e43b8be67aebe6af4ba3e.json"}}, {"family": "Koelkebeck", "given": "Katja", "initials": "K", "orcid": "0000-0002-0469-3997", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/63a95a4ddeca4835afd611a064d3dacf.json"}}, {"family": "Hepdurgun", "given": "Cenan", "initials": "C", "orcid": "0000-0002-2809-0277", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8bdd4d5544674a94a6418472283e5648.json"}}, {"family": "Zafar", "given": "Ali", "initials": "A", "orcid": "0000-0002-1305-7407", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3834361e7e34408890e0889c9dc6668e.json"}}, {"family": "Fiorillo", "given": "Andrea", "initials": "A", "orcid": "0000-0002-6926-0762", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89a321877c9049918b8fec9cd5b09c84.json"}}], "type": "journal article", "published": "2021-12-07", "journal": {"title": "Asia Pac Psychiatry", "issn": "1758-5872", "pages": "e12499", "issn-l": null}, "abstract": "The COVID-19 pandemic has disrupted scientific gatherings and conferences, opening up opportunities for virtual learning platforms. Realizing the potential of online academic exchanges, the World Psychiatric Association (WPA) also developed virtual avenues and information systems for capacity building of mental health professionals across the world. Among its first such initiatives, the WPA organized a virtual Train the Trainers workshop, where 123 psychiatrists, psychiatric trainees, and educators from 45 countries participated. The innovative and interactive workshop allowed participants to get to know each other, exchange educational and professional experiences, and ask questions or receive advice from experts. Keynote speakers, including WPA President Prof. Afzal Javed and Prof. Norman Sartorius, stressed upon the importance of finding innovative solutions in psychiatry training and the need to improve teaching and training in the field of psychiatry, especially in the provision of leadership and communication skills. Online training methods can provide easy access to academics and students while reducing the organizational and logistical costs. They have the potential to improve educational equality and allow the voice of the underprivileged scientists to be heard across the globe. The devastating impact on access to mental health services during COVID-19 underscores the urgent need for online training, particularly in countries where the ratio of psychiatrists to patients is inadequate and doctors concentrate more on treatment than on research and education. Virtual educational interventions could prove incredibly useful in the future just as they are being successfully utilized in local and regional contexts during the pandemic.", "doi": "10.1111/appy.12499", "pmid": "34873842", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-12-12T07:10:44.650Z", "modified": "2021-12-12T07:10:45.043Z"}, {"entity": "publication", "iuid": "8e1f894a5f5249e5961aebb3314dfbfd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e1f894a5f5249e5961aebb3314dfbfd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e1f894a5f5249e5961aebb3314dfbfd"}}, "title": "Resilience in care organisations: challenges in maintaining support for vulnerable people in Europe during the Covid-19 pandemic.", "authors": [{"family": "Orru", "given": "Kati", "initials": "K"}, {"family": "Nero", "given": "Kristi", "initials": "K"}, {"family": "Naevestad", "given": "Tor-Olav", "initials": "TO"}, {"family": "Schieffelers", "given": "Abriel", "initials": "A"}, {"family": "Olson", "given": "Alexandra", "initials": "A"}, {"family": "Airola", "given": "Merja", "initials": "M"}, {"family": "Kazemekaityte", "given": "Austeja", "initials": "A"}, {"family": "Lovasz", "given": "Gabriella", "initials": "G"}, {"family": "Scurci", "given": "Giuseppe", "initials": "G"}, {"family": "Ludvigsen", "given": "Johanna", "initials": "J"}, {"family": "de Los Rios P\u00e9rez", "given": "Daniel A", "initials": "DA"}], "type": "journal article", "published": "2021-12-07", "journal": {"title": "Disasters", "issn": "1467-7717", "issn-l": null}, "abstract": "The Covid-19 pandemic has challenged the resilience of care organisations (and those dependent on them), especially when services are stopped or restricted. This study focuses on the experiences of care organisations that offer services to individuals in highly precarious situations in 10 European countries. It is based on 32 qualitative interviews and three workshops with managers and staff. The four key types of organisations reviewed largely had the same adaptation patterns in all countries. The most drastic changes were experienced by day centres, which had to suspend or digitise services, whereas night shelters and soup kitchens had to reorganise broadly their work; residential facilities were minimally affected. Given the drastic surge in demand for services, reliance on an overburdened (volunteer) workforce, and a lack of crisis plans, the care organisations with long-term trust networks with clients and intra-organisational cooperation adapted easier. The outcomes were worse for new clients, migrants, psychologically vulnerable people, and those with limited communicative abilities.", "doi": "10.1111/disa.12526", "pmid": "34874082", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-12-12T07:11:20.679Z", "modified": "2021-12-12T07:11:36.858Z"}, {"entity": "publication", "iuid": "a9889a45330745ef9afbcd594c736357", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a9889a45330745ef9afbcd594c736357.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a9889a45330745ef9afbcd594c736357"}}, "title": "Plasma Proteome Fingerprints Reveal Distinctiveness and Clinical Outcome of SARS-CoV-2 Infection.", "authors": [{"family": "Bauer", "given": "Wolfgang", "initials": "W", "orcid": "0000-0002-1063-3237", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae14a94fec6e47a58fb0571d872eb474.json"}}, {"family": "Weber", "given": "Marcus", "initials": "M"}, {"family": "Diehl-Wiesenecker", "given": "Eva", "initials": "E"}, {"family": "Galtung", "given": "Noa", "initials": "N", "orcid": "0000-0002-4379-9516", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/afc2ffad4bff4f3bbddc701f06254b53.json"}}, {"family": "Prpic", "given": "Monika", "initials": "M"}, {"family": "Somasundaram", "given": "Rajan", "initials": "R"}, {"family": "Tauber", "given": "Rudolf", "initials": "R"}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67a59fa5de37434c8b7151039c192a37.json"}}, {"family": "Micke", "given": "Patrick", "initials": "P", "orcid": "0000-0003-1210-5961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24f9f5e6c72d414b869d2adeed4b9951.json"}}, {"family": "Kappert", "given": "Kai", "initials": "K", "orcid": "0000-0001-6976-0428", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/803023090ed64c3eb77f84a84d561c67.json"}}], "type": "journal article", "published": "2021-12-07", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "13", "issue": "12", "pages": "2456"}, "abstract": "We evaluated how plasma proteomic signatures in patients with suspected COVID-19 can unravel the pathophysiology, and determine kinetics and clinical outcome of the infection.\r\n\r\nPlasma samples from patients presenting to the emergency department (ED) with symptoms of COVID-19 were stratified into: (1) patients with suspected COVID-19 that was not confirmed (n = 44); (2) non-hospitalized patients with confirmed COVID-19 (n = 44); (3) hospitalized patients with confirmed COVID-19 (n = 53) with variable outcome; and (4) patients presenting to the ED with minor diseases unrelated to SARS-CoV-2 infection (n = 20). Besides standard of care diagnostics, 177 circulating proteins related to inflammation and cardiovascular disease were analyzed using proximity extension assay (PEA, Olink) technology.\r\n\r\nComparative proteome analysis revealed 14 distinct proteins as highly associated with SARS-CoV-2 infection and 12 proteins with subsequent hospitalization (p < 0.001). ADM, IL-6, MCP-3, TRAIL-R2, and PD-L1 were each predictive for death (AUROC curve 0.80-0.87). The consistent increase of these markers, from hospital admission to intensive care and fatality, supported the concept that these proteins are of major clinical relevance.\r\n\r\nWe identified distinct plasma proteins linked to the presence and course of COVID-19. These plasma proteomic findings may translate to a protein fingerprint, helping to assist clinical management decisions.", "doi": "10.3390/v13122456", "pmid": "34960725", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Drug discovery and repurposing of drugs": null}, "xrefs": [{"db": "pii", "key": "v13122456"}, {"db": "pmc", "key": "PMC8706135"}], "notes": [], "created": "2021-12-18T18:26:19.356Z", "modified": "2022-01-04T15:50:46.848Z"}, {"entity": "publication", "iuid": "2fe18e9c5e8a46e291d0c66359a4a8f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2fe18e9c5e8a46e291d0c66359a4a8f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2fe18e9c5e8a46e291d0c66359a4a8f8"}}, "title": "Imiquimod Boosts Interferon Response, and Decreases ACE2 and Pro-Inflammatory Response of Human Bronchial Epithelium in Asthma.", "authors": [{"family": "Nieto-Fontarigo", "given": "Juan Jos\u00e9", "initials": "JJ"}, {"family": "Tillgren", "given": "Sofia", "initials": "S"}, {"family": "Cerps", "given": "Samuel", "initials": "S"}, {"family": "Sverrild", "given": "Asger", "initials": "A"}, {"family": "Hvidtfeldt", "given": "Morten", "initials": "M"}, {"family": "Ramu", "given": "Sangeetha", "initials": "S"}, {"family": "Menzel", "given": "Mandy", "initials": "M"}, {"family": "Sander", "given": "Adam Frederik", "initials": "AF"}, {"family": "Porsbjerg", "given": "Celeste", "initials": "C"}, {"family": "Uller", "given": "Lena", "initials": "L"}], "type": "journal article", "published": "2021-12-07", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "12", "pages": "743890", "issn-l": "1664-3224"}, "abstract": "Both anti-viral and anti-inflammatory bronchial effects are warranted to treat viral infections in asthma. We sought to investigate if imiquimod, a TLR7 agonist, exhibits such dual actions in ex vivo cultured human bronchial epithelial cells (HBECs), targets for SARS-CoV-2 infectivity.\n\nTo investigate bronchial epithelial effects of imiquimod of potential importance for anti-viral treatment in asthmatic patients.\n\nEffects of imiquimod alone were examined in HBECs from healthy (N=4) and asthmatic (N=18) donors. Mimicking SARS-CoV-2 infection, HBECs were stimulated with poly(I:C), a dsRNA analogue, or SARS-CoV-2 spike-protein 1 (SP1; receptor binding) with and without imiquimod treatment. Expression of SARS-CoV-2 receptor (ACE2), pro-inflammatory and anti-viral cytokines were analyzed by RT-qPCR, multiplex ELISA, western blot, and Nanostring and proteomic analyses.\n\nImiquimod reduced ACE2 expression at baseline and after poly(I:C) stimulation. Imiquimod also reduced poly(I:C)-induced pro-inflammatory cytokines including IL-1\u03b2, IL-6, IL-8, and IL-33. Furthermore, imiquimod increased IFN-\u03b2 expression, an effect potentiated in presence of poly(I:C) or SP1. Multiplex mRNA analysis verified enrichment in type-I IFN signaling concomitant with suppression of cytokine signaling pathways induced by imiquimod in presence of poly(I:C). Exploratory proteomic analyses revealed potentially protective effects of imiquimod on infections.\n\nImiquimod triggers viral resistance mechanisms in HBECs by decreasing ACE2 and increasing IFN-\u03b2 expression. Additionally, imiquimod improves viral infection tolerance by reducing viral stimulus-induced epithelial cytokines involved in severe COVID-19 infection. Our imiquimod data highlight feasibility of producing pluripotent drugs potentially suited for anti-viral treatment in asthmatic subjects.", "doi": "10.3389/fimmu.2021.743890", "pmid": "34950134", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8688760"}], "notes": [], "created": "2022-01-04T15:28:07.292Z", "modified": "2022-01-04T15:28:07.306Z"}, {"entity": "publication", "iuid": "635c7b339a06434fa64ae02072cf14ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/635c7b339a06434fa64ae02072cf14ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/635c7b339a06434fa64ae02072cf14ef"}}, "title": "An observational study of intermediate or high dose thromboprophylaxis for critically ill COVID-19 patients.", "authors": [{"family": "Jonmarker", "given": "Sandra", "initials": "S", "orcid": "0000-0001-5836-8594", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d28ab27b84f40e2b3d57c91595ece92.json"}}, {"family": "Litorell", "given": "Jacob", "initials": "J"}, {"family": "Dahlberg", "given": "Martin", "initials": "M"}, {"family": "Stackelberg", "given": "Otto", "initials": "O"}, {"family": "Everhov", "given": "\u00c5sa H", "initials": "\u00c5H"}, {"family": "S\u00f6derberg", "given": "M\u00e5rten", "initials": "M"}, {"family": "Rubenson-Wahlin", "given": "Rebecka", "initials": "R"}, {"family": "G\u00fcnther", "given": "Mattias", "initials": "M", "orcid": "0000-0003-2372-6114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9150a7883334344ba7c4abfbe273fef.json"}}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}, {"family": "Hollenberg", "given": "Jacob", "initials": "J"}, {"family": "Joelsson-Alm", "given": "Eva", "initials": "E", "orcid": "0000-0002-9041-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07a091265e654b21bc27fa14b93e4ec0.json"}}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-12-07", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172"}, "abstract": "Critically ill COVID-19 patients have a high reported incidence of thromboembolic complications and the optimal dose of thromboprophylaxis is not yet determined. The aim of this study was to investigate if 90-day mortality differed between patients treated with intermediate or high dose thromboprophylaxis.\n\nIn this retrospective study, all critically ill COVID-19 patients admitted to intensive care from March 6 until July 15, 2020, were eligible. Patients were categorized into groups according to daily dose of thromboprophylaxis. Dosing was based on local standardized recommendations, not on degree of critical illness or risk of thrombosis. Cox proportional hazards regression was used to estimate hazard ratios of death within 90 days from ICU admission. Multivariable models were adjusted for sex, age, body-mass index, Simplified Acute Physiology Score III, invasive respiratory support, glucocorticoids, and dosing strategy of thromboprophylaxis.\n\nA total of 165 patients were included; 92 intermediate and 73 high dose thromboprophylaxis. Baseline characteristics did not differ between groups. The 90-day mortality was 19.6% in patients with intermediate dose and 19.2% in patients with high dose thromboprophylaxis. Multivariable hazard ratio of death within 90 days was 0.74 (95% CI, 0.36-1.53) for the high dose group compared to intermediate dose group. Multivariable hazard ratio for thromboembolic events and bleedings within 28 days were 0.93 (95% CI 0.37-2.29) and 0.84 (95% CI 0.28-2.54) for high versus intermediate dose, respectively.\n\nA difference in 90-day mortality between intermediate and high dose thromboprophylaxis could neither be confirmed nor rejected due to a small sample size.", "doi": "10.1111/aas.14013", "pmid": "34875111", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-12T07:14:59.689Z", "modified": "2021-12-12T07:14:59.804Z"}, {"entity": "publication", "iuid": "ceb2eb041f8846e2909fc611030c9123", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ceb2eb041f8846e2909fc611030c9123.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ceb2eb041f8846e2909fc611030c9123"}}, "title": "1H, 13C and 15N resonance assignment of the SARS-CoV-2 full-length nsp1 protein and its mutants reveals its unique secondary structure features in solution.", "authors": [{"family": "Agback", "given": "Tatiana", "initials": "T"}, {"family": "Dominguez", "given": "Francisco", "initials": "F"}, {"family": "Frolov", "given": "Ilya", "initials": "I"}, {"family": "Frolova", "given": "Elena I", "initials": "EI"}, {"family": "Agback", "given": "Peter", "initials": "P", "orcid": "0000-0003-2226-0746", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/660f06a0871c4d87a362f2a7dbf1dc98.json"}}], "type": "journal article", "published": "2021-12-07", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "12", "pages": "e0251834", "issn-l": "1932-6203"}, "abstract": "Structural characterization of the SARS-CoV-2 full length nsp1 protein will be an essential tool for developing new target-directed antiviral drugs against SARS-CoV-2 and for further understanding of intra- and intermolecular interactions of this protein. As a first step in the NMR studies of the protein, we report the 1H, 13C and 15N resonance backbone assignment as well as the C\u03b2 of the apo form of the full-lengthSARS-CoV-2 nsp1 including the folded domain together with the flaking N- and C- terminal intrinsically disordered fragments. The 19.8 kD protein was characterized by high-resolution NMR. Validation of assignment have been done by using two different mutants, H81P and K129E/D48E as well as by amino acid specific experiments. According to the obtained assignment, the secondary structure of the folded domain in solution was almost identical to its previously published X-ray structure as well as another published secondary structure obtained by NMR, but some discrepancies have been detected. In the solution SARS-CoV-2 nsp1 exhibited disordered, flexible N- and C-termini with different dynamic characteristics. The short peptide in the beginning of the disordered C-terminal domain adopted two different conformations distinguishable on the NMR time scale. We propose that the disordered and folded nsp1 domains are not fully independent units but are rather involved in intramolecular interactions. Studies of the structure and dynamics of the SARS-CoV-2 mutant in solution are on-going and will provide important insights into the molecular mechanisms underlying these interactions.", "doi": "10.1371/journal.pone.0251834", "pmid": "34874953", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-14234"}, {"db": "URL", "key": "https://bmrb.io/data_library/summary/index.php?bmrbId=50915", "description": "https://bmrb.io/data_library/summary/index.php?bmrbId=50915"}], "notes": [], "created": "2021-12-12T07:11:59.861Z", "modified": "2021-12-12T07:14:03.149Z"}, {"entity": "publication", "iuid": "2ebebec3c32942c3bf6b1fd15d1623fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ebebec3c32942c3bf6b1fd15d1623fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ebebec3c32942c3bf6b1fd15d1623fa"}}, "title": "Impact of the COVID-19 pandemic on food production and animal health.", "authors": [{"family": "Rahimi", "given": "Parastoo", "initials": "P"}, {"family": "Islam", "given": "Md Saiful", "initials": "MS"}, {"family": "Duarte", "given": "Phelipe Magalh\u00e3es", "initials": "PM"}, {"family": "Tazerji", "given": "Sina Salajegheh", "initials": "SS"}, {"family": "Sobur", "given": "Md Abdus", "initials": "MA"}, {"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME"}, {"family": "Ashour", "given": "Hossam M", "initials": "HM"}, {"family": "Rahman", "given": "Md Tanvir", "initials": "MT"}], "type": "journal article", "published": "2021-12-06", "journal": {"title": "Trends Food Sci Technol", "issn": "0924-2244", "issn-l": null}, "abstract": "The new coronavirus, named the severe acute respiratory coronavirus syndrome 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 2019 (COVID-19). COVID-19 originated in China and spread to other countries and continents causing a variety of respiratory and non-respiratory symptoms that led to death in severe cases.\n\nIn this review, we discuss and analyze the impact of the COVID-19 pandemic on animal production systems and food products including meat, dairy, eggs, and processed food, in addition to assessing the pandemic's impact on animal health care systems, animal health care quality, animal welfare, food chain sustainability, and the global economy. We also provide effective recommendations to animal producers, veterinary healthcare professionals, workers in animal products industries, and governments to alleviate the effects of the pandemic on livestock farming and production systems.\n\nPort restrictions, border restrictions, curfews, and social distancing limitations led to reduced quality, productivity, and competitiveness of key productive sectors. The restrictions have hit the livestock sector hard by disrupting the animal feed supply chain, reducing animal farming services, limiting animal health services including delays in diagnosis and treatment of diseases, limiting access to markets and consumers, and reducing labor-force participation. The inhumane culling of animals jeopardized animal welfare. Egg smashing, milk dumping, and other animal product disruptions negatively impacted food production, consumption, and access to food originating from animals. In summary, COVID-triggered lockdowns and limitations on local and international trade have taken their toll on food production, animal production, and animal health and welfare. COVID-19 reverberations could exacerbate food insecurity, hunger, and global poverty. The effects could be massive on the most vulnerable populations and the poorest nations.", "doi": "10.1016/j.tifs.2021.12.003", "pmid": "34898853", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0924-2244(21)00660-9"}, {"db": "pmc", "key": "PMC8647343"}], "notes": [], "created": "2021-12-18T18:00:15.493Z", "modified": "2021-12-18T18:00:15.507Z"}, {"entity": "publication", "iuid": "6033244c29174016b12902edef9cdb24", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6033244c29174016b12902edef9cdb24.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6033244c29174016b12902edef9cdb24"}}, "title": "Convalescence plasma treatment of COVID-19: results from a prematurely terminated randomized controlled open-label study in Southern Sweden.", "authors": [{"family": "Holm", "given": "Karin", "initials": "K", "orcid": "0000-0002-8289-5949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7f590df41084ab28d7a1ac80b1b90e7.json"}}, {"family": "Lundgren", "given": "Maria N", "initials": "MN"}, {"family": "Kjeldsen-Kragh", "given": "Jens", "initials": "J"}, {"family": "Ljungquist", "given": "Oskar", "initials": "O"}, {"family": "B\u00f6ttiger", "given": "Blenda", "initials": "B"}, {"family": "Wik\u00e9n", "given": "Christian", "initials": "C"}, {"family": "\u00d6berg", "given": "Jonas", "initials": "J"}, {"family": "Fernstr\u00f6m", "given": "Nils", "initials": "N"}, {"family": "Rosendal", "given": "Ebba", "initials": "E"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "Wigren Bystr\u00f6m", "given": "Julia", "initials": "J"}, {"family": "Forsell", "given": "Mattias", "initials": "M"}, {"family": "Landin-Olsson", "given": "Mona", "initials": "M"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-12-04", "journal": {"title": "BMC Res Notes", "issn": "1756-0500", "volume": "14", "issue": "1", "pages": "440", "issn-l": null}, "abstract": "Convalescent plasma has been tried as therapy for various viral infections. Early observational studies of convalescent plasma treatment for hospitalized COVID-19 patients were promising, but randomized controlled studies were lacking at the time. The objective of this study was to investigate if convalescent plasma is beneficial to hospitalized patients with COVID-19.\n\nHospitalized patients with confirmed COVID-19 and an oxygen saturation below 94% were randomized 1:1 to receive convalescent plasma in addition to standard of care or standard of care only. The primary outcome was number of days of oxygen treatment to keep saturation above 93% within 28 days from inclusion. The study was prematurely terminated when thirty-one of 100 intended patients had been included. The median time of oxygen treatment among survivors was 11 days (IQR 6-15) for the convalescent plasma group and 7 days (IQR 5-9) for the standard of care group (p = 0.4, median difference -4). Two patients in the convalescent plasma group and three patients in the standard of care group died (p = 0.64, OR 0.49, 95% CI 0.08-2.79). Thus no significant differences were observed between the groups. Trial registration ClinicalTrials NCT04600440, retrospectively registered Oct 23, 2020.", "doi": "10.1186/s13104-021-05847-7", "pmid": "34863304", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13104-021-05847-7"}, {"db": "ClinicalTrials.gov", "key": "NCT04600440"}], "notes": [], "created": "2021-12-12T07:18:34.485Z", "modified": "2021-12-12T07:18:34.529Z"}, {"entity": "publication", "iuid": "e1e268c1633f431a94c89397bef8d775", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e1e268c1633f431a94c89397bef8d775.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e1e268c1633f431a94c89397bef8d775"}}, "title": "Longevity of anti-spike and anti-nucleocapsid antibodies after COVID-19 in solid organ transplant recipients compared to immunocompetent controls.", "authors": [{"family": "S\u00f8fteland", "given": "John Mackay", "initials": "JM", "orcid": "0000-0001-7993-5906", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ab059cbe643422e9da67347e1123200.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Liljeqvist", "given": "Jan-\u00c5ke", "initials": "J\u00c5"}, {"family": "Friman", "given": "Vanda", "initials": "V"}, {"family": "de Coursey", "given": "Emily", "initials": "E"}, {"family": "Karason", "given": "Kristjan", "initials": "K"}, {"family": "Ekelund", "given": "Jan", "initials": "J"}, {"family": "Felldin", "given": "Marie", "initials": "M"}, {"family": "Magnusson", "given": "Jesper", "initials": "J", "orcid": "0000-0002-5630-0155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d2adc110fad45618c8dc73505a3358b.json"}}, {"family": "Baid-Agrawal", "given": "Seema", "initials": "S"}, {"family": "Wallquist", "given": "Carin", "initials": "C"}, {"family": "Schult", "given": "Andreas", "initials": "A"}, {"family": "Jacobsson", "given": "Hanna", "initials": "H"}, {"family": "Bergdahl", "given": "Anders", "initials": "A"}, {"family": "Bemark", "given": "Mats", "initials": "M", "orcid": "0000-0001-7416-9819", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ae923943b6c4b4bb74ca1e14b426351.json"}}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Holm Gunnarsson", "given": "Inger", "initials": "I"}, {"family": "Stenstr\u00f6m", "given": "Jan", "initials": "J"}, {"family": "Leach", "given": "Susannah", "initials": "S", "orcid": "0000-0002-9614-2753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18d00be831d241dca238b3253d1b45f6.json"}}], "type": "journal article", "published": "2021-12-03", "journal": {"title": "Am J Transplant", "issn": "1600-6143", "issn-l": null}, "abstract": "Solid organ transplant recipients (SOTRs) are on lifelong immunosuppression, which may interfere with adaptive immunity to COVID-19. The data on dynamics and duration of antibody response in SOTRs are limited. This longitudinal study examined the longevity of both anti-spike (S)- and anti-nucleocapsid (N)-specific IgG-antibodies after COVID-19 in SOTRs compared to matched immunocompetent persons. SOTRs (n=65) were matched with controls (n=65) for COVID-19 disease severity, age, and sex in order of priority. Serum-IgG-antibodies against N- and S-antigens of SARS-CoV-2 were analyzed. At 1 and 9 months after COVID-19, anti-S-IgG detectability decreased from 91% to 82% in SOTRs versus 100% to 95% in controls, whereas the anti-N-IgG decreased from 63% to 29% in SOTRs versus 89% to 46% in controls. A matched paired analysis showed SOTRs having significantly lower levels of anti-N-IgG at all time points (1-month P=0.007, 3-months P<0.001, 6-months P=0.019 and 9-months P=0.021) but not anti-S-IgG at any time points. A mixed-model analysis confirmed these findings except for anti-S-IgG at one month (p=0.005) and identified severity score as the most important predictor of antibody response. SOTRs mount comparable S-specific, but not N-specific, antibody responses to SARS-CoV-2 infection compared to immunocompetent controls.", "doi": "10.1111/ajt.16909", "pmid": "34860447", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-13T06:15:42.289Z", "modified": "2021-12-13T06:16:04.675Z"}, {"entity": "publication", "iuid": "4d61723b79c4473b863d8be10bd85269", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4d61723b79c4473b863d8be10bd85269.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4d61723b79c4473b863d8be10bd85269"}}, "title": "Waning infant pertussis during COVID-19 pandemic.", "authors": [{"family": "Falkenstein-Hagander", "given": "Kathy", "initials": "K", "orcid": "0000-0001-8070-8591", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6bc0ee6ad2a241be887a0261ffcec215.json"}}, {"family": "Appelqvist", "given": "Emma", "initials": "E"}, {"family": "Cavefors", "given": "Ann-Sofie Frisk", "initials": "AF"}, {"family": "K\u00e4llberg", "given": "Henrik", "initials": "H"}, {"family": "Nilsson", "given": "Lennart Jan", "initials": "LJ"}, {"family": "Silfverdal", "given": "Sven-Arne", "initials": "SA", "orcid": "0000-0002-3606-3797", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82e58fba252946a091a386588684f781.json"}}, {"family": "Storsaeter", "given": "Jann", "initials": "J"}, {"family": "Aronsson", "given": "Bernice", "initials": "B"}], "type": "journal article", "published": "2021-12-02", "journal": {"title": "Arch Dis Child", "issn": "1468-2044", "issn-l": null}, "abstract": "Measures to reduce the spread of COVID-19 have been associated with reduction in other respiratory infections. Results of a national Swedish cohort study of infant pertussis during April 2020-September 2021 were compared with those during January 2014-March 2020. The number of pertussis cases decreased significantly during the COVID-19 pandemic, from an average of 21 infant cases per quarter of a year before the pandemic to an average of 1 case per quarter during the pandemic. Swedish strategies to mitigate the spread of COVID-19 seem to have had an impact on pertussis incidence in infants.", "doi": "10.1136/archdischild-2021-323055", "pmid": "34857511", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "archdischild-2021-323055"}], "notes": [], "created": "2021-12-18T18:07:33.933Z", "modified": "2021-12-18T18:07:34.039Z"}, {"entity": "publication", "iuid": "ced65694d052422c83e7f1562e1398ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ced65694d052422c83e7f1562e1398ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ced65694d052422c83e7f1562e1398ca"}}, "title": "Soluble Urokinase Plasminogen Activator Receptor (suPAR) Independently Predicts Severity and Length of Hospitalisation in Patients With COVID-19.", "authors": [{"family": "Enocsson", "given": "Helena", "initials": "H"}, {"family": "Idoff", "given": "Cornelia", "initials": "C"}, {"family": "Gustafsson", "given": "Annette", "initials": "A"}, {"family": "Govender", "given": "Melissa", "initials": "M"}, {"family": "Hopkins", "given": "Francis", "initials": "F"}, {"family": "Larsson", "given": "Marie", "initials": "M"}, {"family": "Nilsdotter-Augustinsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Sj\u00f6wall", "given": "Johanna", "initials": "J"}], "type": "journal article", "published": "2021-12-02", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "8", "pages": "791716", "issn-l": null}, "abstract": "Background: Efficient healthcare based on prognostic variables in hospitalised patients with COVID-19 could reduce the risk of complications and death. Recently, soluble urokinase Plasminogen Activator Receptor (suPAR) was shown to predict respiratory failure, kidney injury, and clinical outcome in patients with SARS-CoV-2 infection. The aim of this study was to investigate the value of suPAR as a prognostic tool, in comparison with other variables, regarding disease severity and length of hospital stay in patients with COVID-19. Patients and Methods: Individuals hospitalised with COVID-19 (40 males, 20 females; median age 57.5 years) with a median symptom duration of 10 days and matched, healthy controls (n = 30) were included. Admission levels of suPAR were measured in serum by enzyme-linked immunosorbent assay. Blood cell counts, C-reactive protein (CRP) levels, lactate dehydrogenase (LDH), plasma creatinine and estimated glomerular filtration rates were analysed and oxygen demand, level of care and length of hospitalisation recorded. Results: Patients had significantly higher suPAR levels compared to controls (P < 0.001). Levels were higher in severely/critically (median 6.6 ng/mL) compared with moderately ill patients (median 5.0 ng/mL; P = 0.002). In addition, suPAR levels correlated with length of hospitalisation (rho = 0.35; P = 0.006). Besides suPAR, LDH, CRP, neutrophil count, neutrophil-to-monocyte and neutrophil-to-lymphocyte ratio, body mass index and chronic renal failure were discriminators of COVID-19 severity and/or predictors of length of hospitalisation. Conclusion: Admission levels of suPAR were higher in patients who developed severe/critical COVID-19 and associated with length of hospital stay. In addition, we showed that suPAR functioned as an independent predictor of COVID-19 disease severity.", "doi": "10.3389/fmed.2021.791716", "pmid": "34926532", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8674575"}], "notes": [], "created": "2022-01-03T15:22:31.284Z", "modified": "2022-01-03T15:22:59.724Z"}, {"entity": "publication", "iuid": "d248640d9017480f810e715041594cc3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d248640d9017480f810e715041594cc3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d248640d9017480f810e715041594cc3"}}, "title": "Randomised clinical trials in critical care: past, present and future.", "authors": [{"family": "Granholm", "given": "Anders", "initials": "A", "orcid": "0000-0001-5799-7655", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d058ecb91d4c482abbee511b044ddf75.json"}}, {"family": "Alhazzani", "given": "Waleed", "initials": "W"}, {"family": "Derde", "given": "Lennie P G", "initials": "LPG"}, {"family": "Angus", "given": "Derek C", "initials": "DC"}, {"family": "Zampieri", "given": "Fernando G", "initials": "FG"}, {"family": "Hammond", "given": "Naomi E", "initials": "NE"}, {"family": "Sweeney", "given": "Rob Mac", "initials": "RM"}, {"family": "Myatra", "given": "Sheila N", "initials": "SN"}, {"family": "Azoulay", "given": "Elie", "initials": "E"}, {"family": "Rowan", "given": "Kathryn", "initials": "K"}, {"family": "Young", "given": "Paul J", "initials": "PJ"}, {"family": "Perner", "given": "Anders", "initials": "A"}, {"family": "M\u00f8ller", "given": "Morten Hylander", "initials": "MH"}], "type": "journal article", "published": "2021-12-02", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "issn-l": "0342-4642"}, "abstract": "Randomised clinical trials (RCTs) are the gold standard for providing unbiased evidence of intervention effects. Here, we provide an overview of the history of RCTs and discuss the major challenges and limitations of current critical care RCTs, including overly optimistic effect sizes; unnuanced conclusions based on dichotomization of results; limited focus on patient-centred outcomes other than mortality; lack of flexibility and ability to adapt, increasing the risk of inconclusive results and limiting knowledge gains before trial completion; and inefficiency due to lack of re-use of trial infrastructure. We discuss recent developments in critical care RCTs and novel methods that may provide solutions to some of these challenges, including a research programme approach (consecutive, complementary studies of multiple types rather than individual, independent studies), and novel design and analysis methods. These include standardization of trial protocols; alternative outcome choices and use of core outcome sets; increased acceptance of uncertainty, probabilistic interpretations and use of Bayesian statistics; novel approaches to assessing heterogeneity of treatment effects; adaptation and platform trials; and increased integration between clinical trials and clinical practice. We outline the advantages and discuss the potential methodological and practical disadvantages with these approaches. With this review, we aim to inform clinicians and researchers about conventional and novel RCTs, including the rationale for choosing one or the other methodological approach based on a thorough discussion of pros and cons. Importantly, the most central feature remains the randomisation, which provides unparalleled restriction of confounding compared to non-randomised designs by reducing confounding to chance.", "doi": "10.1007/s00134-021-06587-9", "pmid": "34853905", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-021-06587-9"}, {"db": "pmc", "key": "PMC8636283"}], "notes": [], "created": "2021-12-18T18:08:36.279Z", "modified": "2021-12-18T18:08:36.311Z"}, {"entity": "publication", "iuid": "4b5d4b1020ba4be3b34456be993e921a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b5d4b1020ba4be3b34456be993e921a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b5d4b1020ba4be3b34456be993e921a"}}, "title": "Lifestyle and mental health 1 year into COVID-19.", "authors": [{"family": "Barbieri", "given": "Paolo Nicola", "initials": "PN"}, {"family": "Giuntella", "given": "Osea", "initials": "O"}, {"family": "Saccardo", "given": "Silvia", "initials": "S"}, {"family": "Sadoff", "given": "Sally", "initials": "S"}], "type": "journal article", "published": "2021-12-02", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "23349", "issn-l": "2045-2322"}, "abstract": "In previous work, Giuntella et al. (Proc Natl Acad Sci 118:e2016632118, 2021), we documented large disruptions to physical activity, sleep, time use and mental health among young adults at the onset of the COVID-19 pandemic in Spring 2020. This study explores the trends 1 year into COVID-19, as vaccines began to roll out, COVID-19 deaths declined, and social distancing measures eased in the United States. We combine biometric and survey data from multiple cohorts of college students spanning Spring 2019 through Spring 2021 (N = 1179). Our results show persistent impacts of the pandemic on physical activity and mental health. One year into the pandemic, daily steps averaged about 6300 per day compared to about 9800 per day prior to the pandemic, a 35% decline. Almost half of participants were at risk of clinical depression compared to a little over one-third prior to the pandemic, a 36% increase. The impacts on screen time, social interactions and sleep duration at the onset of COVID-19 largely dissipated over the course of the pandemic, though screen time remained significantly higher than pre-pandemic levels. In contrast to the sharp changes in lifestyle and mental health documented as the pandemic emerged in March 2020, we do not find evidence of behavioral changes or improvements in mental well-being over the course of Spring 2021 as the pandemic eased.", "doi": "10.1038/s41598-021-02702-4", "pmid": "34857806", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-02702-4"}, {"db": "pmc", "key": "PMC8640003"}], "notes": [], "created": "2021-12-18T18:07:18.938Z", "modified": "2021-12-18T18:07:18.950Z"}, {"entity": "publication", "iuid": "6bda32f2b9534efea4411fa34bd79b94", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6bda32f2b9534efea4411fa34bd79b94.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6bda32f2b9534efea4411fa34bd79b94"}}, "title": "Secondary effects of the COVID-19 pandemic on surgical management of hepatopancreatobiliary malignancies in the Nordic capitals.", "authors": [{"family": "Holmberg", "given": "Marcus", "initials": "M", "orcid": "0000-0002-7217-4240", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76b4c749d77a400d83c23c415c1162de.json"}}, {"family": "Koppatz", "given": "Hanna", "initials": "H"}, {"family": "Jansson", "given": "Anders", "initials": "A"}, {"family": "Hillings\u00f8", "given": "Jens Georg", "initials": "JG", "orcid": "0000-0002-2381-7836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb166927097b40fe82cacd2d2f4793bf.json"}}, {"family": "Noergaard Larsen", "given": "Peter", "initials": "P"}, {"family": "Lassen", "given": "Kristoffer", "initials": "K", "orcid": "0000-0003-0039-6554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/401fe4d0146a494db0e6cf59b7be9d54.json"}}, {"family": "Sallinen", "given": "Ville", "initials": "V", "orcid": "0000-0001-5394-4169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/85f283d1d6554ad5a8475ceb27e195bc.json"}}, {"family": "Yaqub", "given": "Sheraz", "initials": "S", "orcid": "0000-0002-5696-2319", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4327b96c3bc4b9fbe30dd894b62c559.json"}}, {"family": "Sparrelid", "given": "Ernesto", "initials": "E"}], "type": "journal article", "published": "2021-12-01", "journal": {"title": "Br J Surg", "issn": "1365-2168", "issn-l": null}, "abstract": null, "doi": "10.1093/bjs/znab405", "pmid": "34850850", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6447105"}], "notes": [], "created": "2021-12-18T18:09:38.851Z", "modified": "2021-12-18T18:09:39.053Z"}, {"entity": "publication", "iuid": "cfb3f01277ce402fbb487d4eb3edf6f5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfb3f01277ce402fbb487d4eb3edf6f5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfb3f01277ce402fbb487d4eb3edf6f5"}}, "title": "Rituximab Infusion Timing, Cumulative Dose, and Hospitalization for COVID-19 in Persons With Multiple Sclerosis in Sweden.", "authors": [{"family": "McKay", "given": "Kyla A", "initials": "KA"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Englund", "given": "Simon", "initials": "S"}, {"family": "He", "given": "Anna", "initials": "A"}, {"family": "Langer-Gould", "given": "Annette", "initials": "A"}, {"family": "Hillert", "given": "Jan", "initials": "J"}, {"family": "Frisell", "given": "Thomas", "initials": "T"}], "type": "clinical trial", "published": "2021-12-01", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "volume": "4", "issue": "12", "pages": "e2136697", "issn-l": null}, "abstract": null, "doi": "10.1001/jamanetworkopen.2021.36697", "pmid": "34851401", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "2786701"}, {"db": "pmc", "key": "PMC8637249"}], "notes": [], "created": "2021-12-18T18:09:05.760Z", "modified": "2021-12-18T18:09:05.773Z"}, {"entity": "publication", "iuid": "249f16ed4f2846019d1404d1d2f0c6f5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/249f16ed4f2846019d1404d1d2f0c6f5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/249f16ed4f2846019d1404d1d2f0c6f5"}}, "title": "Occupational exposure and risk of transmission of SARS-CoV2 among European anaesthetists.", "authors": [{"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Longrois", "given": "Dan", "initials": "D"}, {"family": "Bruder", "given": "Nicolas", "initials": "N"}], "type": "journal article", "published": "2021-12-01", "journal": {"title": "Eur J Anaesthesiol", "issn": "1365-2346", "volume": "38", "issue": "12", "pages": "1272-1273", "issn-l": null}, "abstract": null, "doi": "10.1097/EJA.0000000000001607", "pmid": "34735396", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "00003643-202112000-00008"}], "notes": [], "created": "2021-11-26T15:40:44.860Z", "modified": "2021-11-26T15:40:44.874Z"}, {"entity": "publication", "iuid": "1022991309d94307b1cdce7fed18bade", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1022991309d94307b1cdce7fed18bade.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1022991309d94307b1cdce7fed18bade"}}, "title": "Impact of the COVID-19 Pandemic on the General Mental Health in Sweden: No Observed Changes in the Dispensed Amount of Common Psychotropic Medications in the Region of Scania.", "authors": [{"family": "Wolfschlag", "given": "Mirjam", "initials": "M"}, {"family": "Grudet", "given": "C\u00e9cile", "initials": "C"}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-12-01", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "731297", "issn-l": "1664-0640"}, "abstract": "Some first investigations have focused on the consequences of the COVID-19 pandemic for the general mental health after its outbreak in 2020. According to multiple self-reporting surveys, symptoms of stress, anxiety, and depression have risen worldwide. Even some studies based on health care records start to be published, providing more objective and statistically reliable results. Additionally, concerns have been raised, to what extend the access to mental health care has been compromised by the COVID-19 outbreak. The aim of this study was to detect changes in prescription trends of common psychotropic medications in the Swedish region of Scania. The monthly dispensed amounts of selected pharmaceuticals were compared from January 2018 until January 2021, regarding the prescription trends before and after the outbreak of COVID-19. Using an interrupted time series analysis for each medication, no general trend changes were observed. On the one hand, a possible deterioration of the general mental health could not be confirmed by these results. On the other hand, the access to mental health care did not seem to be impaired by the pandemic. When interpreting findings related to the COVID-19 pandemic, regional differences and country-specific approaches for coping with the pandemic should be considered. The Swedish population, for instance, never experienced a full \"lock-down\" and within Sweden the time point of the outbreak waves differed regionally. In general, the effects of the COVID-19 outbreak on mental health are still unclear and need to be investigated further in an international comparison.", "doi": "10.3389/fpsyt.2021.731297", "pmid": "34925084", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8671297"}], "notes": [], "created": "2022-01-03T15:22:11.541Z", "modified": "2022-01-03T15:22:11.553Z"}, {"entity": "publication", "iuid": "975ae46bee0a4573a8a3cb07c24dbab1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/975ae46bee0a4573a8a3cb07c24dbab1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/975ae46bee0a4573a8a3cb07c24dbab1"}}, "title": "Immunogenicity and tolerability of COVID-19 vaccination in peritoneal dialysis patients-A prospective observational cohort study.", "authors": [{"family": "Haase", "given": "Michael", "initials": "M", "orcid": "0000-0001-8212-7416", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3d5795641ee4ff0ab46f79603ba5e73.json"}}, {"family": "Lesny", "given": "Paul", "initials": "P"}, {"family": "Haase-Fielitz", "given": "Anja", "initials": "A"}, {"family": "Anderson", "given": "Mark", "initials": "M"}, {"family": "Cloherty", "given": "Gavin", "initials": "G"}, {"family": "Stec", "given": "Michael", "initials": "M"}, {"family": "Lucas", "given": "Carlos", "initials": "C"}, {"family": "Santos-Araujo", "given": "Carla", "initials": "C"}, {"family": "Haarhaus", "given": "Mathias", "initials": "M"}, {"family": "Macario", "given": "Fernando", "initials": "F"}], "type": "journal article", "published": "2021-12-01", "journal": {"title": "Semin Dial", "issn": "1525-139X", "issn-l": null}, "abstract": "In peritoneal dialysis (PD) patients, information on the immunogenicity and tolerability of SARS-CoV-2 vaccination is still scarce. We compared the immunogenicity and tolerability of SARS-CoV-2 vaccination of PD patients with that of medical personnel.\n\nIn a prospective observational cohort study, PD patients and immunocompetent medical personnel were evaluated for SARS-CoV-2 spike-IgG- and Nucleocapsid-IgG-antibody-levels before, 2 weeks after the first, and 6 weeks after the second SARS-CoV-2 vaccination and vaccine tolerability after the first and second vaccination.\n\nIn COVID-19-na\u00efve PD patients (N = 19), lower SARS-CoV-2-spike-IgG-levels were found compared with COVID-19-na\u00efve medical personnel (N = 24) 6 weeks after second vaccination (median 1438 AU/ml [25th-75th percentile 775-5261] versus 4577 [1529-9871]; p = 0.045). This finding resulted in a lower rate of strong vaccine response (spike-IgG \u2265 1000 AU/ml) of COVID-19-na\u00efve PD patients compared with medical personnel (58% versus 92%; p = 0.013), but not for seroconversion rate (spike-IgG \u2265 50 AU/ml: 100% vs. 100%; p > 0.99). After first vaccination, COVID-na\u00efve PD patients presented with significantly fewer side effects than medical personnel (number of any side effect: 1 [1-2] vs. 4 [1-7]; p = 0.015). A similar pattern with slightly decreased frequencies of side effects was observed for tolerability of second SARS-CoV-2 vaccination in PD patients and medical personnel (number of any side effects: 1 [1-1] vs. 2 [1-5]; p = 0.006).\n\nSARS-CoV-2 vaccination in COVID-19-na\u00efve PD patients appeared to induce a very high rate of seroconversion but a substantially lower rate of patients with a strong response compared with medical personnel. Vaccination appeared to be safe in the PD patients studied.", "doi": "10.1111/sdi.13043", "pmid": "34854131", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T18:08:07.445Z", "modified": "2021-12-18T18:08:07.524Z"}, {"entity": "publication", "iuid": "a1d55643d2544ade95def5ade92d4e63", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a1d55643d2544ade95def5ade92d4e63.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a1d55643d2544ade95def5ade92d4e63"}}, "title": "First comparison of conventional activated sludge versus root-zone treatment for SARS-CoV-2 RNA removal from wastewaters: Statistical and temporal significance.", "authors": [{"family": "Kumar", "given": "Manish", "initials": "M"}, {"family": "Kuroda", "given": "Keisuke", "initials": "K"}, {"family": "Joshi", "given": "Madhvi", "initials": "M"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Barcelo", "given": "Damia", "initials": "D"}], "type": "journal article", "published": "2021-12-01", "journal": {"title": "Chem Eng J", "issn": "1385-8947", "volume": "425", "pages": "130635", "issn-l": null}, "abstract": "In the initial pandemic phase, effluents from wastewater treatment facilities were reported mostly free from Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) RNA, and thus conventional wastewater treatments were generally considered effective. However, there is a lack of first-hand data on i) comparative efficacy of various treatment processes for SARS-CoV-2 RNA removal; and ii) temporal variations in the removal efficacy of a given treatment process in the backdrop of active COVID-19 cases. This work provides a comparative account of the removal efficacy of conventional activated sludge (CAS) and root zone treatments (RZT) based on weekly wastewater surveillance data, consisting of forty-four samples, during a two-month period. The average genome concentration was higher in the inlets of CAS-based wastewater treatment plant (WWTP) in the Sargasan ward (1.25 \u00d7 103 copies/ L), than that of RZT-based WWTP (7.07 \u00d7 102 copies/ L) in an academic institution campus of Gandhinagar, Gujarat, India. ORF 1ab and S genes appeared to be more sensitive to treatment i.e., significantly reduced (p < 0.05) than N genes (p > 0.05). CAS treatment exhibited better RNA removal efficacy (p = 0.014) than RZT (p = 0.032). Multivariate analyses suggested that the effective genome concentration should be calculated based on the presence/absence of multiple genes. The present study stresses that treated effluents are not always free from SARS-CoV-2 RNA, and the removal efficacy of a given WWTP is prone to exhibit temporal variability owing to variations in active COVID-19 cases in the vicinity and genetic material accumulation over the time. Disinfection seems less effective than the adsorption and coagulation processes for SARS-CoV-2 removal. Results stress the need for further research on mechanistic insight on SARS-CoV-2 removal through various treatment processes taking solid-liquid partitioning into account.", "doi": "10.1016/j.cej.2021.130635", "pmid": "34149304", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S1385-8947(21)02221-X"}, {"db": "pmc", "key": "PMC8200644"}], "notes": [], "created": "2021-06-28T18:24:38.522Z", "modified": "2021-06-28T18:25:01.598Z"}, {"entity": "publication", "iuid": "43d35f6703f84ec795db14f09a692c1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/43d35f6703f84ec795db14f09a692c1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/43d35f6703f84ec795db14f09a692c1d"}}, "title": "Emergence of new SARS-CoV-2 Variant of Concern Omicron (B.1.1.529) - highlights Africa's research capabilities, but exposes major knowledge gaps, inequities of vaccine distribution, inadequacies in global COVID-19 response and control efforts.", "authors": [{"family": "Petersen", "given": "Eskild", "initials": "E"}, {"family": "Ntoumi", "given": "Francine", "initials": "F"}, {"family": "Hui", "given": "David S", "initials": "DS"}, {"family": "Abubakar", "given": "Aisha", "initials": "A"}, {"family": "Kramer", "given": "Laura D", "initials": "LD"}, {"family": "Obiero", "given": "Christina", "initials": "C"}, {"family": "Tambyah", "given": "Paul Anantharajah", "initials": "PA"}, {"family": "Blumberg", "given": "Lucille", "initials": "L"}, {"family": "Yapi", "given": "Richard", "initials": "R"}, {"family": "Al-Abri", "given": "Seif", "initials": "S"}, {"family": "Pinto", "given": "Tatiana de Castro Abreu", "initials": "TCA"}, {"family": "Yeboah-Manu", "given": "Dorothy", "initials": "D"}, {"family": "Haider", "given": "Najmul", "initials": "N"}, {"family": "Asogun", "given": "Danny", "initials": "D"}, {"family": "Velavan", "given": "Thirumalaisamy P", "initials": "TP"}, {"family": "Kapata", "given": "Nathan", "initials": "N"}, {"family": "Bates", "given": "Matthew", "initials": "M"}, {"family": "Ansumana", "given": "Rashid", "initials": "R"}, {"family": "Montaldo", "given": "Chiara", "initials": "C"}, {"family": "Mucheleng'anga", "given": "Luchenga", "initials": "L"}, {"family": "Tembo", "given": "John", "initials": "J"}, {"family": "Mwaba", "given": "Peter", "initials": "P"}, {"family": "Himwaze", "given": "Cordelia M", "initials": "CM"}, {"family": "Hamid", "given": "Muzamil Mahdi Abdel", "initials": "MMA"}, {"family": "Mfinanga", "given": "Sayoki", "initials": "S"}, {"family": "Mboera", "given": "Leonard", "initials": "L"}, {"family": "Raj", "given": "Tajudeen", "initials": "T"}, {"family": "Aklillu", "given": "Eleni", "initials": "E"}, {"family": "Veas", "given": "Francisco", "initials": "F"}, {"family": "Edwards", "given": "Sarah", "initials": "S"}, {"family": "Kaleebu", "given": "Pontiano", "initials": "P"}, {"family": "McHugh", "given": "Timothy D", "initials": "TD"}, {"family": "Chakaya", "given": "Jeremiah", "initials": "J"}, {"family": "Nyirenda", "given": "Thomas", "initials": "T"}, {"family": "Bockarie", "given": "Moses", "initials": "M"}, {"family": "Nyasulu", "given": "Peter S", "initials": "PS"}, {"family": "Wejse", "given": "Christian", "initials": "C"}, {"family": "Muyembe-Tamfum", "given": "Jean-Jacques", "initials": "JJ"}, {"family": "Azhar", "given": "Esam I", "initials": "EI"}, {"family": "Maeurer", "given": "Markus", "initials": "M"}, {"family": "Nachega", "given": "Jean B", "initials": "JB"}, {"family": "Kock", "given": "Richard", "initials": "R"}, {"family": "Ippolito", "given": "Giuseppe", "initials": "G"}, {"family": "Zumla", "given": "Alimuddin", "initials": "A"}], "type": "editorial", "published": "2021-12-01", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712"}, "abstract": null, "doi": "10.1016/j.ijid.2021.11.040", "pmid": "34863925", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)00888-2"}], "notes": [], "created": "2021-12-12T07:17:49.046Z", "modified": "2021-12-12T07:17:49.060Z"}, {"entity": "publication", "iuid": "d8a5430224524a14a61f7f510d8ee762", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d8a5430224524a14a61f7f510d8ee762.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d8a5430224524a14a61f7f510d8ee762"}}, "title": "Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality", "authors": [{"family": "Nakanishi", "given": "Tomoko", "initials": "T", "orcid": "0000-0001-9510-5646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd273e50091d44c3b3e8d1473ce89b0a.json"}}, {"family": "Pigazzini", "given": "Sara", "initials": "S", "orcid": "0000-0002-0641-9393", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b0633eaa95524db89712be8570a96731.json"}}, {"family": "Degenhardt", "given": "Frauke", "initials": "F", "orcid": "0000-0001-7516-3179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab8dc6a0eb504f41a89c140d68b87b6a.json"}}, {"family": "Cordioli", "given": "Mattia", "initials": "M", "orcid": "0000-0002-4872-0520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/973dc15953ef42ddb7844615904f887d.json"}}, {"family": "Butler-Laporte", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-5388-0396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/529dc69151d3463e8480b975d70fa759.json"}}, {"family": "Maya-Miles", "given": "Douglas", "initials": "D", "orcid": "0000-0002-0669-6526", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1ef23ddbaa8475192c07bd33bcbf435.json"}}, {"family": "Bujanda", "given": "Luis", "initials": "L", "orcid": "0000-0002-4353-9968", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de96cde07e1d49d2a2001537b317111a.json"}}, {"family": "Bouysran", "given": "Youssef", "initials": "Y"}, {"family": "Niemi", "given": "Mari E K", "initials": "MEK", "orcid": "0000-0003-0696-6175", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87d6c30c910c4c989095e2f026194490.json"}}, {"family": "Palom", "given": "Adriana", "initials": "A", "orcid": "0000-0002-0130-1302", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a89c9483db484981ad3f218056b35c9a.json"}}, {"family": "Ellinghaus", "given": "David", "initials": "D", "orcid": "0000-0002-4332-6110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a6cdcc3819e45a08ab598ae7afbfb94.json"}}, {"family": "Khan", "given": "Atlas", "initials": "A"}, {"family": "Mart\u00ednez-Bueno", "given": "Manuel", "initials": "M"}, {"family": "Rolker", "given": "Selina", "initials": "S"}, {"family": "Amitrano", "given": "Sara", "initials": "S"}, {"family": "Roade Tato", "given": "Luisa", "initials": "L"}, {"family": "Fava", "given": "Francesca", "initials": "F"}, {"family": "Spinner", "given": "Christoph D", "initials": "CD", "orcid": "0000-0002-3875-5367", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c506eb763b34155bbc6187f4ccb5f62.json"}}, {"family": "Prati", "given": "Daniele", "initials": "D", "orcid": "0000-0002-2281-7498", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/050d5b4534914e2cb3c9ec64bc5fedaa.json"}}, {"family": "Bernardo", "given": "David", "initials": "D", "orcid": "0000-0002-2843-6696", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5cdb7b8db1f4cb18eda0884c430704f.json"}}, {"family": "Garcia", "given": "Federico", "initials": "F"}, {"family": "Darcis", "given": "Gilles", "initials": "G"}, {"family": "Fern\u00e1ndez-Cadenas", "given": "Israel", "initials": "I"}, {"family": "Holter", "given": "Jan Cato", "initials": "JC", "orcid": "0000-0003-1618-5022", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7b6512c252a422badaaa120ee2aa700.json"}}, {"family": "Banales", "given": "Jesus M", "initials": "JM"}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Kiryluk", "given": "Krzysztof", "initials": "K", "orcid": "0000-0002-5047-6715", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d1362394dec4a7e934fd6c79ad94df3.json"}}, {"family": "Duga", "given": "Stefano", "initials": "S", "orcid": "0000-0003-3457-1410", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f14e5b5dec36415fa1627265d55f8754.json"}}, {"family": "Asselta", "given": "Rosanna", "initials": "R"}, {"family": "Pereira", "given": "Alexandre C", "initials": "AC", "orcid": "0000-0002-7782-5540", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bb55d803b824076b67a01d2790d2986.json"}}, {"family": "Romero-G\u00f3mez", "given": "Manuel", "initials": "M", "orcid": "0000-0001-8494-8947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64e5a4afafa14d5eaeb7957c0061622a.json"}}, {"family": "Nafr\u00eda-Jim\u00e9nez", "given": "Beatriz", "initials": "B", "orcid": "0000-0002-4698-5680", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/782c0cfe62d94457a45fa94098bf3aab.json"}}, {"family": "Hov", "given": "Johannes R", "initials": "JR", "orcid": "0000-0002-5900-8096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83964c456ae5424f8138304aa9dbc26b.json"}}, {"family": "Migeotte", "given": "Isabelle", "initials": "I"}, {"family": "Renieri", "given": "Alessandra", "initials": "A"}, {"family": "Planas", "given": "Anna M", "initials": "AM", "orcid": "0000-0002-6147-1880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ecaec25d7eeb43bca29edd1ed56cecc7.json"}}, {"family": "Ludwig", "given": "Kerstin U", "initials": "KU", "orcid": "0000-0002-8541-2519", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02922a1f71c64a8e9dc6aa1c29a20270.json"}}, {"family": "Buti", "given": "Maria", "initials": "M", "orcid": "0000-0002-0732-3078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4207dfbc876c49a58e210b056d3b0191.json"}}, {"family": "Rahmouni", "given": "Souad", "initials": "S", "orcid": "0000-0003-0956-0242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4dac12a55b94325b711fd13394a4285.json"}}, {"family": "Alarc\u00f3n-Riquelme", "given": "Marta E", "initials": "ME", "orcid": "0000-0002-7632-4154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f74dd701d8442c992fe172be2d2c5bf.json"}}, {"family": "Schulte", "given": "Eva C", "initials": "EC", "orcid": "0000-0003-3105-5672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b02ec0962cdc4e15853c4a3aeba4992d.json"}}, {"family": "Franke", "given": "Andre", "initials": "A"}, {"family": "Karlsen", "given": "Tom H", "initials": "TH"}, {"family": "Valenti", "given": "Luca", "initials": "L", "orcid": "0000-0001-8909-0345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/964a9d9544f64f2080930bcaec06d1cf.json"}}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ee1510080704cf6a2a6972deb94123f.json"}}, {"family": "Richards", "given": "J Brent", "initials": "JB", "orcid": "0000-0002-3746-9086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8994152547ee4765b1653b834c52a21a.json"}}, {"family": "Ganna", "given": "Andrea", "initials": "A"}], "type": "journal-article", "published": "2021-12-01", "journal": {"title": "J Clin Invest", "issn": "1558-8238", "issn-l": null, "volume": "131", "issue": "23", "pages": null}, "abstract": "Abstract\r\nBackground There is considerable variability in COVID-19 outcomes amongst younger adults\u2014and some of this variation may be due to genetic predisposition. We characterized the clinical implications of the major genetic risk factor for COVID-19 severity, and its age-dependent effect, using individual-level data in a large international multi-centre consortium.\r\n\r\nMethod The major common COVID-19 genetic risk factor is a chromosome 3 locus, tagged by the marker rs10490770. We combined individual level data for 13,424 COVID-19 positive patients (N=6,689 hospitalized) from 17 cohorts in nine countries to assess the association of this genetic marker with mortality, COVID-19-related complications and laboratory values. We next examined if the magnitude of these associations varied by age and were independent from known clinical COVID-19 risk factors.\r\n\r\nFindings We found that rs10490770 risk allele carriers experienced an increased risk of all-cause mortality (hazard ratio [HR] 1\u00b74, 95% confidence interval [CI] 1\u00b72\u20131\u00b76) and COVID-19 related mortality (HR 1\u00b75, 95%CI 1\u00b73\u20131\u00b78). Risk allele carriers had increased odds of several COVID-19 complications: severe respiratory failure (odds ratio [OR] 2\u00b70, 95%CI 1\u00b76-2\u00b76), venous thromboembolism (OR 1\u00b77, 95%CI 1\u00b72-2\u00b74), and hepatic injury (OR 1\u00b76, 95%CI 1\u00b72-2\u00b70). Risk allele carriers \u2264 60 years had higher odds of death or severe respiratory failure (OR 2\u00b76, 95%CI 1\u00b78-3\u00b79) compared to those > 60 years OR 1\u00b75 (95%CI 1\u00b73-1\u00b79, interaction p-value=0\u00b704). Amongst individuals \u2264 60 years who died or experienced severe respiratory COVID-19 outcome, we found that 31\u00b78% (95%CI 27\u00b76-36\u00b72) were risk variant carriers, compared to 13\u00b79% (95%CI 12\u00b76-15\u00b72%) of those not experiencing these outcomes. Prediction of death or severe respiratory failure among those \u2264 60 years improved when including the risk allele (AUC 0\u00b782 vs 0\u00b784, p=0\u00b7016) and the prediction ability of rs10490770 risk allele was similar to, or better than, most established clinical risk factors.\r\n\r\nInterpretation The major common COVID-19 risk locus on chromosome 3 is associated with increased risks of morbidity and mortality\u2014and these are more pronounced amongst individuals \u2264 60 years. The effect on COVID-19 severity was similar to, or larger than most established risk factors, suggesting potential implications for clinical risk management.", "doi": "10.1172/jci152386", "pmid": "34597274", "labels": {"Category: Genomics & transcriptomics": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: VR": null, "Type: Journal article": null}, "xrefs": [{"db": "URL", "key": "https://www.medrxiv.org/node/316122.external-links.html", "description": "Procedures for accessing data can be found here (data cannot be publicly shared)"}], "notes": [], "created": "2021-03-15T17:30:18.883Z", "modified": "2022-02-14T16:22:27.472Z"}, {"entity": "publication", "iuid": "900640627af44768b241c6508c8be114", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/900640627af44768b241c6508c8be114.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/900640627af44768b241c6508c8be114"}}, "title": "ACE2 Peptide Fragment Interaction with Different S1 Protein Sites.", "authors": [{"family": "Kuznetsov", "given": "Aleksei", "initials": "A"}, {"family": "Arukuusk", "given": "Piret", "initials": "P"}, {"family": "H\u00e4rk", "given": "Heleri", "initials": "H"}, {"family": "Juronen", "given": "Erkki", "initials": "E"}, {"family": "Ustav", "given": "Mart", "initials": "M"}, {"family": "Langel", "given": "\u00dclo", "initials": "\u00dc"}, {"family": "J\u00e4rv", "given": "Jaak", "initials": "J", "orcid": "0000-0003-1042-2701", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/420b8713e79744df8f4f8c4b83c120d1.json"}}], "type": "journal article", "published": "2021-12-01", "journal": {"title": "Int J Pept Res Ther", "issn": "1573-3149", "volume": "28", "issue": "1", "pages": "7", "issn-l": null}, "abstract": "We study the effect of the peptide QAKTFLDKFNHEAEDLFYQ on the kinetics of the SARS-CoV-2 spike protein S1 binding to angiotensin-converting enzyme 2 (ACE2), with the aim to characterize the interaction mechanism of the SARS-CoV2 virus with its host cell. This peptide corresponds to the sequence 24-42 of the ACE2 \u03b11 domain, which marks the binding site for the S1 protein. The kinetics of S1-ACE2 complex formation was measured in the presence of various concentrations of the peptide using bio-layer interferometry. Formation of the S1-ACE2 complex was inhibited by the peptide in cases where it was preincubated with S1 protein before the binding experiment. The kinetic analysis of S1-ACE2 complex dissociation revealed that preincubation stabilized this complex, and this effect was dependent on the peptide concentration as well as the preincubation time. The results point to the formation of the ternary complex of S1 with ACE2 and the peptide. This is possible in the presence of another binding site for the S1 protein beside the receptor-binding domain for ACE2, which binds the peptide QAKTFLDKFNHEAEDLFYQ. Therefore, we conducted computational mapping of the S1 protein surface, revealing two additional binding sites located at some distance from the main receptor-binding domain on S1. We suggest the possibility to predict and test the short protein derived peptides for development of novel strategies in inhibiting virus infections.\n\nThe online version contains supplementary material available at 10.1007/s10989-021-10324-7.", "doi": "10.1007/s10989-021-10324-7", "pmid": "34867130", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10324"}, {"db": "pmc", "key": "PMC8634746"}], "notes": [], "created": "2021-12-12T07:06:25.059Z", "modified": "2021-12-12T07:06:25.142Z"}, {"entity": "publication", "iuid": "1837bfc6926f48cfa24e4dedbed1098a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1837bfc6926f48cfa24e4dedbed1098a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1837bfc6926f48cfa24e4dedbed1098a"}}, "title": "To be or not to be vaccinated against COVID-19 - The adolescents' perspective - A mixed-methods study in Sweden.", "authors": [{"family": "Nilsson", "given": "S", "initials": "S"}, {"family": "Mattson", "given": "J", "initials": "J"}, {"family": "Berghammer", "given": "M", "initials": "M"}, {"family": "Brorsson", "given": "A-L", "initials": "AL"}, {"family": "Forsner", "given": "M", "initials": "M"}, {"family": "Jenholt Nolbris", "given": "M", "initials": "M"}, {"family": "Kull", "given": "I", "initials": "I"}, {"family": "Lindholm Olinder", "given": "A", "initials": "A"}, {"family": "Ragnarsson", "given": "S", "initials": "S"}, {"family": "Rullander", "given": "A-C", "initials": "AC"}, {"family": "Rydstr\u00f6m", "given": "L-L", "initials": "LL"}, {"family": "Andr\u00e9ia Garcia de Avila", "given": "M", "initials": "M"}, {"family": "Olaya-Contreras", "given": "P", "initials": "P"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Vaccine X", "issn": "2590-1362", "issn-l": null, "volume": "9", "issue": null, "pages": "100117"}, "abstract": "Vaccination of the population seems to be an important strategy in halting the COVID-19 pandemic in both local and global society. The aim of this study was to explore Swedish adolescents' willingness to be vaccinated against COVID-19 and its association with sociodemographic and other possible factors. A survey was distributed in Sweden between 7 July and 8 November 2020. The main qualitative question concerned adolescents' thoughts on vaccination against COVID-19 and evaluated whether the adolescents would like to be vaccinated when a COVID-19 vaccine is made available. In total, 702 adolescents aged between 15 and 19 responded to the questionnaire. A convergent parallel mixed-methods design was used. The results showed that nearly one in three adolescents had not decided if they wanted to get a COVID-19 vaccine, i.e. 30.5%: n = 214. Of the participants 54.3% (n = 381) were willing to be vaccinated. Girls had higher levels of anxiety about the vaccine compared to boys. In addition, high levels of anxiety impacted on the participants' willingness to be vaccinated. One reason for being undecided about the vaccine was that participants felt they did not know enough about it. Practising social distancing increased willingness to be vaccinated, as reflected in the qualitative results which showed participants wanted to be vaccinated to protect others. The results impart important knowledge to healthcare professionals and contribute to their communication with adolescents about vaccine hesitancy.", "doi": "10.1016/j.jvacx.2021.100117", "pmid": "34693273", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S2590-1362(21)00034-6"}, {"db": "pmc", "key": "PMC8524812"}], "notes": [], "created": "2021-10-26T18:23:43.089Z", "modified": "2021-11-29T06:17:03.926Z"}, {"entity": "publication", "iuid": "a50334cf1c724ceaa95e3cc107ba0693", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a50334cf1c724ceaa95e3cc107ba0693.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a50334cf1c724ceaa95e3cc107ba0693"}}, "title": "The Unyvero Hospital-Acquired pneumonia panel for diagnosis of secondary bacterial pneumonia in COVID-19 patients.", "authors": [{"family": "Tellapragada", "given": "Chaitanya", "initials": "C"}, {"family": "Giske", "given": "Christian G", "initials": "CG"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Eur J Clin Microbiol Infect Dis", "issn": "1435-4373", "volume": "40", "issue": "12", "pages": "2479-2485", "issn-l": null}, "abstract": "The study was undertaken to evaluate the performance of Unyvero Hospitalized Pneumonia (HPN) panel application, a multiplex PCR-based method for the detection of bacterial pathogens from lower respiratory tract (LRT) samples, obtained from COVID-19 patients with suspected secondary hospital-acquired pneumonia. Residual LRT samples obtained from critically ill COVID-19 patients with predetermined microbiological culture results were tested using the Unyvero HPN Application. Performance evaluation of the HPN Application was carried out using the standard-of-care (SoC) microbiological culture findings as the reference method. Eighty-three LRT samples were used in the evaluation. The HPN Application had a full concordance with SoC findings in 59/83 (71%) samples. The new method detected additional bacterial species in 21 (25%) and failed at detecting a bacterial species present in lower respiratory culture in 3 (3.6%) samples. Overall the sensitivity, specificity, positive, and negative predictive values of the HPN Application were 95.1% (95%CI 96.5-98.3%), 98.3% (95% CI 97.5-98.9%), 71.6% (95% CI 61.0-80.3%), and 99.8% (95% CI 99.3-99.9%), respectively. In conclusion, the HPN Application demonstrated higher diagnostic yield in comparison with the culture and generated results within 5 h.", "doi": "10.1007/s10096-021-04194-6", "pmid": "33661410", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10096-021-04194-6"}, {"db": "pmc", "key": "PMC7930892"}], "notes": [], "created": "2021-03-06T10:23:44.394Z", "modified": "2021-11-18T12:18:22.450Z"}, {"entity": "publication", "iuid": "706709cf6e124a22a1aa0c37efde7172", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/706709cf6e124a22a1aa0c37efde7172.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/706709cf6e124a22a1aa0c37efde7172"}}, "title": "Swedish middle school students' psychosocial well-being during the COVID-19 pandemic: A longitudinal study.", "authors": [{"family": "Vira", "given": "Emily G", "initials": "EG"}, {"family": "Skoog", "given": "Ther\u00e9se", "initials": "T"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "SSM Popul Health", "issn": "2352-8273", "volume": "16", "pages": "100942", "issn-l": null}, "abstract": "Child well-being concerns amidst the COVID-19 pandemic have been reported from countries with strict lockdowns and school closures. Sweden's middle school students attended school as normal during the pandemic, but it is still unknown how their well-being has changed during the pandemic. This study aimed to assess differences in Swedish students' psychosocial well-being from before to during the pandemic. Longitudinal data (N = 849) were collected via self-report surveys across two time-points separated by approximately one year. The second data collection took place 8-9 months after the start of the pandemic in Sweden. We measured psychological adjustment, relationships to significant others and school adjustment. Findings revealed significant mean-level decreases in students' school adjustment during the pandemic. There were no meaningful mean-level decreases in students' relationships to significant others. Students' psychological adjustment showed significant but mostly negligible mean-level decreases, and no differences in emotional problems during the pandemic. The findings are explained based on students' developmental stage and the handling of the pandemic in the Swedish school context. Based on this first longitudinal study on students' wellbeing during the COVID-19 pandemic, we conclude that Swedish middle school students who continued formal schooling show mainly positive adaptations, and thus appear to be resilient during the COVID-19 pandemic.", "doi": "10.1016/j.ssmph.2021.100942", "pmid": "34664029", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2352-8273(21)00217-2"}, {"db": "pmc", "key": "PMC8516135"}], "notes": [], "created": "2021-10-21T04:57:18.209Z", "modified": "2021-10-21T04:57:18.231Z"}, {"entity": "publication", "iuid": "078e400f924141a7b6ac8c40f1daf541", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/078e400f924141a7b6ac8c40f1daf541.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/078e400f924141a7b6ac8c40f1daf541"}}, "title": "Revival of ecological studies during the COVID-19 pandemic.", "authors": [{"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}, {"family": "Modig", "given": "Karin", "initials": "K"}, {"family": "Kahn", "given": "Fredrik", "initials": "F"}, {"family": "Ahlbom", "given": "Anders", "initials": "A", "orcid": "0000-0003-1093-1901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f33a2deb34d945878518ba196b3f6728.json"}}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Eur J Epidemiol", "issn": "1573-7284", "volume": "36", "issue": "12", "pages": "1225-1229", "issn-l": "0393-2990"}, "abstract": null, "doi": "10.1007/s10654-021-00830-9", "pmid": "34951671", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10654-021-00830-9"}, {"db": "pmc", "key": "PMC8703212"}], "notes": [], "created": "2022-01-04T15:26:57.207Z", "modified": "2022-01-04T15:27:31.950Z"}, {"entity": "publication", "iuid": "904eec4259f24c22aa26316b21f08c15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/904eec4259f24c22aa26316b21f08c15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/904eec4259f24c22aa26316b21f08c15"}}, "title": "Respiratory infection risk-based ventilation design method.", "authors": [{"family": "Kurnitski", "given": "Jarek", "initials": "J"}, {"family": "Kiil", "given": "Martin", "initials": "M"}, {"family": "Wargocki", "given": "Pawel", "initials": "P"}, {"family": "Boerstra", "given": "Atze", "initials": "A"}, {"family": "Sepp\u00e4nen", "given": "Olli", "initials": "O"}, {"family": "Olesen", "given": "Bjarne", "initials": "B"}, {"family": "Morawska", "given": "Lidia", "initials": "L"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Build Environ", "issn": "0360-1323", "volume": "206", "pages": "108387", "issn-l": null}, "abstract": "A new design method is proposed to calculate outdoor air ventilation rates to control respiratory infection risk in indoor spaces. We propose to use this method in future ventilation standards to complement existing ventilation criteria based on the perceived air quality and pollutant removal. The proposed method makes it possible to calculate the required ventilation rate at a given probability of infection and quanta emission rate. Present work used quanta emission rates for SARS-CoV-2 and consequently the method can be applied for other respiratory viruses with available quanta data. The method was applied to case studies representing typical rooms in public buildings. To reduce the probability of infection, the total airflow rate per infectious person revealed to be the most important parameter to reduce the infection risk. Category I ventilation rate prescribed in the EN 16798-1 standard satisfied many but not all type of spaces examined. The required ventilation rates started from about 80 L/s per room. Large variations between the results for the selected case studies made it impossible to provide a simple rule for estimating the required ventilation rates. Consequently, we conclude that to design rooms with a low infection risk the newly developed ventilation design method must be used.", "doi": "10.1016/j.buildenv.2021.108387", "pmid": "34602721", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0360-1323(21)00784-8"}, {"db": "pmc", "key": "PMC8462055"}], "notes": [], "created": "2021-10-11T18:01:41.194Z", "modified": "2021-10-11T18:01:41.235Z"}, {"entity": "publication", "iuid": "ad6319278115441b8d67e949c2c8929f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ad6319278115441b8d67e949c2c8929f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ad6319278115441b8d67e949c2c8929f"}}, "title": "Patterns and predictors of sick leave after Covid-19 and long Covid in a national Swedish cohort", "authors": [{"family": "Westerlind", "given": "Emma", "initials": "E"}, {"family": "Palstam", "given": "Annie", "initials": "A"}, {"family": "Sunnerhagen", "given": "Katharina S", "initials": "KS"}, {"family": "Persson", "given": "Hanna C", "initials": "HC"}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "1023"}, "abstract": "The impact of Covid-19 and its long-term consequences is not yet fully understood. Sick leave can be seen as an indicator of health in a working age population, and the present study aimed to investigate sick-leave patterns after Covid-19, and potential factors predicting longer sick leave in hospitalised and non-hospitalised people with Covid-19.\r\n\r\nThe present study is a comprehensive national registry-based study in Sweden with a 4-month follow-up. All people who started to receive sickness benefits for Covid-19 during March 1 to August 31, 2020, were included. Predictors of sick leave \u22651 month and long Covid (\u226512 weeks) were analysed with logistic regression in the total population and in separate models depending on inpatient care due to Covid-19.\r\n\r\nA total of 11,955 people started sick leave for Covid-19 within the inclusion period. The median sick leave was 35 days, 13.3% were on sick leave for long Covid, and 9.0% remained on sick leave for the whole follow-up period. There were 2960 people who received inpatient care due to Covid-19, which was the strongest predictor of longer sick leave. Sick leave the year prior to Covid-19 and older age also predicted longer sick leave. No clear pattern of socioeconomic factors was noted.\r\n\r\nA substantial number of people are on sick leave due to Covid-19. Sick leave may be protracted, and sick leave for long Covid is quite common. The severity of Covid-19 (needing inpatient care), prior sick leave, and age all seem to predict the likelihood of longer sick leave. However, no socioeconomic factor could clearly predict longer sick leave, indicating the complexity of this condition. The group needing long sick leave after Covid-19 seems to be heterogeneous, indicating a knowledge gap.", "doi": "10.1186/s12889-021-11013-2", "pmid": "34059034", "labels": {"Category: Rehabilitation": null, "Category: Post-COVID": null, "Type: Journal article": null, "Funder: Forte": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11013-2"}], "notes": [], "created": "2021-06-02T13:13:29.154Z", "modified": "2021-11-19T10:41:14.086Z"}, {"entity": "publication", "iuid": "f3ea01c51f5943808fabda31a757f721", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f3ea01c51f5943808fabda31a757f721.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f3ea01c51f5943808fabda31a757f721"}}, "title": "Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study.", "authors": [{"family": "Sattui", "given": "Sebastian E", "initials": "SE"}, {"family": "Conway", "given": "Richard", "initials": "R"}, {"family": "Putman", "given": "Michael S", "initials": "MS"}, {"family": "Seet", "given": "Andrea M", "initials": "AM"}, {"family": "Gianfrancesco", "given": "Milena A", "initials": "MA"}, {"family": "Beins", "given": "Kaley", "initials": "K"}, {"family": "Hill", "given": "Catherine", "initials": "C"}, {"family": "Liew", "given": "David", "initials": "D"}, {"family": "Mackie", "given": "Sarah L", "initials": "SL"}, {"family": "Mehta", "given": "Puja", "initials": "P"}, {"family": "Neill", "given": "Lorna", "initials": "L"}, {"family": "Gomez", "given": "Gimena", "initials": "G"}, {"family": "Salinas", "given": "Maria Isabel Haye", "initials": "MIH"}, {"family": "Maldonado", "given": "Federico Nicolas", "initials": "FN"}, {"family": "Mariz", "given": "Henrique Ataide", "initials": "HA"}, {"family": "de Sousa Studart", "given": "Samia Araujo", "initials": "SA"}, {"family": "Araujo", "given": "Nafice Costa", "initials": "NC"}, {"family": "Knight", "given": "Ann", "initials": "A"}, {"family": "Rozza", "given": "Davide", "initials": "D"}, {"family": "Quartuccio", "given": "Luca", "initials": "L"}, {"family": "Samson", "given": "Maxime", "initials": "M"}, {"family": "Bally", "given": "St\u00e9phane", "initials": "S"}, {"family": "Maria", "given": "Alexandre Tj", "initials": "AT"}, {"family": "Chazerain", "given": "Pascal", "initials": "P"}, {"family": "Hasseli", "given": "Rebecca", "initials": "R"}, {"family": "M\u00fcller-Ladner", "given": "Ulf", "initials": "U"}, {"family": "Hoyer", "given": "Bimba F", "initials": "BF"}, {"family": "Voll", "given": "Reinhard", "initials": "R"}, {"family": "Torres", "given": "Rita Pinheiro", "initials": "RP"}, {"family": "Luis", "given": "Mariana", "initials": "M"}, {"family": "Ribeirio", "given": "Sandra Lucia Euzebio", "initials": "SLE"}, {"family": "Al-Emadi", "given": "Samar", "initials": "S"}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA"}, {"family": "Hsu", "given": "Tiffany Y-T", "initials": "TY"}, {"family": "D'Silva", "given": "Kristin M", "initials": "KM"}, {"family": "Patel", "given": "Naomi J", "initials": "NJ"}, {"family": "Wise", "given": "Leanna", "initials": "L"}, {"family": "Gilbert", "given": "Emily", "initials": "E"}, {"family": "Almada", "given": "Maria Valenzuela", "initials": "MV"}, {"family": "Duarte-Garc\u00eda", "given": "Al\u00ed", "initials": "A"}, {"family": "Ugarte-Gil", "given": "Manuel", "initials": "M"}, {"family": "Jacobsohn", "given": "Lindsay", "initials": "L"}, {"family": "Izadi", "given": "Zara", "initials": "Z"}, {"family": "Strangfeld", "given": "Anja", "initials": "A"}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL"}, {"family": "Gossec", "given": "Laure", "initials": "L"}, {"family": "Carmona", "given": "Loreto", "initials": "L"}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S"}, {"family": "Kearsley-Fleet", "given": "Lianne", "initials": "L"}, {"family": "Schaefer", "given": "Martin", "initials": "M"}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS"}, {"family": "Sufka", "given": "Paul", "initials": "P"}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Grainger", "given": "Rebecca", "initials": "R"}, {"family": "Machado", "given": "Pedro M", "initials": "PM"}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Yazdany", "given": "Jinoos", "initials": "J"}, {"family": "Robinson", "given": "Philip C", "initials": "PC"}, {"family": "Global Rheumatology Alliance", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Lancet Rheumatol", "issn": "2665-9913", "volume": "3", "issue": "12", "pages": "e855-e864", "issn-l": null}, "abstract": "Patients with primary systemic vasculitis or polymyalgia rheumatica might be at a high risk for poor COVID-19 outcomes due to the treatments used, the potential organ damage cause by primary systemic vasculitis, and the demographic factors associated with these conditions. We therefore aimed to investigate factors associated with COVID-19 outcomes in patients with primary systemic vasculitis or polymyalgia rheumatica.\n\nIn this retrospective cohort study, adult patients (aged \u226518 years) diagnosed with COVID-19 between March 12, 2020, and April 12, 2021, who had a history of primary systemic vasculitis (antineutrophil cytoplasmic antibody [ANCA]-associated vasculitis, giant cell arteritis, Beh\u00e7et's syndrome, or other vasculitis) or polymyalgia rheumatica, and were reported to the COVID-19 Global Rheumatology Alliance registry were included. To assess COVID-19 outcomes in patients, we used an ordinal COVID-19 severity scale, defined as: (1) no hospitalisation; (2) hospitalisation without supplemental oxygen; (3) hospitalisation with any supplemental oxygen or ventilation; or (4) death. Multivariable ordinal logistic regression analyses were used to estimate odds ratios (ORs), adjusting for age, sex, time period, number of comorbidities, smoking status, obesity, glucocorticoid use, disease activity, region, and medication category. Analyses were also stratified by type of rheumatic disease.\n\nOf 1202 eligible patients identified in the registry, 733 (61\u00b70%) were women and 469 (39\u00b70%) were men, and their mean age was 63\u00b78 years (SD 17\u00b71). A total of 374 (31\u00b71%) patients had polymyalgia rheumatica, 353 (29\u00b74%) had ANCA-associated vasculitis, 183 (15\u00b72%) had giant cell arteritis, 112 (9\u00b73%) had Beh\u00e7et's syndrome, and 180 (15\u00b70%) had other vasculitis. Of 1020 (84\u00b79%) patients with outcome data, 512 (50\u00b72%) were not hospitalised, 114 (11\u00b72%) were hospitalised and did not receive supplemental oxygen, 239 (23\u00b74%) were hospitalised and received ventilation or supplemental oxygen, and 155 (15\u00b72%) died. A higher odds of poor COVID-19 outcomes were observed in patients who were older (per each additional decade of life OR 1\u00b744 [95% CI 1\u00b731-1\u00b757]), were male compared with female (1\u00b738 [1\u00b705-1\u00b780]), had more comorbidities (per each additional comorbidity 1\u00b739 [1\u00b723-1\u00b758]), were taking 10 mg/day or more of prednisolone compared with none (2\u00b714 [1\u00b750-3\u00b704]), or had moderate, or high or severe disease activity compared with those who had disease remission or low disease activity (2\u00b712 [1\u00b749-3\u00b702]). Risk factors varied among different disease subtypes.\n\nAmong patients with primary systemic vasculitis and polymyalgia rheumatica, severe COVID-19 outcomes were associated with variable and largely unmodifiable risk factors, such as age, sex, and number of comorbidities, as well as treatments, including high-dose glucocorticoids. Our results could be used to inform mitigation strategies for patients with these diseases.\n\nAmerican College of Rheumatology and the European Alliance of Associations for Rheumatology.", "doi": "10.1016/S2665-9913(21)00316-7", "pmid": "34778843", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2665-9913(21)00316-7"}, {"db": "pmc", "key": "PMC8570701"}], "notes": [], "created": "2021-11-26T14:13:12.026Z", "modified": "2021-11-26T14:13:12.041Z"}, {"entity": "publication", "iuid": "74a2d3a88e74486eb9d5899b4fbb201d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/74a2d3a88e74486eb9d5899b4fbb201d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/74a2d3a88e74486eb9d5899b4fbb201d"}}, "title": "Nudging healthcare professionals to improve treatment of COVID-19: a narrative review", "authors": [{"family": "Vilhelmsson", "given": "Andreas", "initials": "A", "orcid": "0000-0002-6635-8182", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48e38ddf17384577a77c07639249ecc8.json"}}, {"family": "Sant'Anna", "given": "Anita", "initials": "A"}, {"family": "Wolf", "given": "Axel", "initials": "A"}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "BMJ Open Qual", "issn": "2399-6641", "volume": "10", "issue": "4", "pages": "e001522", "issn-l": null}, "abstract": null, "doi": "10.1136/bmjoq-2021-001522", "pmid": null, "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:54:04.021Z", "modified": "2021-12-12T06:54:04.271Z"}, {"entity": "publication", "iuid": "5d2e70aff6164745ab02cd7192646084", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d2e70aff6164745ab02cd7192646084.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d2e70aff6164745ab02cd7192646084"}}, "title": "Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms.", "authors": [{"family": "Zhong", "given": "Wen", "initials": "W"}, {"family": "Altay", "given": "Ozlem", "initials": "O"}, {"family": "Arif", "given": "Muhammad", "initials": "M"}, {"family": "Edfors", "given": "Fredrik", "initials": "F"}, {"family": "Doganay", "given": "Levent", "initials": "L"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A"}, {"family": "Uhlen", "given": "Mathias", "initials": "M"}, {"family": "Fagerberg", "given": "Linn", "initials": "L", "orcid": "0000-0003-0198-7137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/735a371341c246a88f09c1efea5a5f57.json"}}], "type": "clinical trial, phase ii", "published": "2021-12-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "volume": "74", "pages": "103723", "issn-l": null}, "abstract": "COVID-19 has caused millions of deaths globally, yet the cellular mechanisms underlying the various effects of the disease remain poorly understood. Recently, a new analytical platform for comprehensive analysis of plasma protein profiles using proximity extension assays combined with next generation sequencing has been developed, which allows for multiple proteins to be analyzed simultaneously without sacrifice on accuracy or sensitivity.\n\nWe analyzed the plasma protein profiles of COVID-19 patients (n = 50) with mild and moderate symptoms by comparing the protein levels in newly diagnosed patients with the protein levels in the same individuals after 14 days.\n\nThe study has identified more than 200 proteins that are significantly elevated during infection and many of these are related to cytokine response and other immune-related functions. In addition, several other proteins are shown to be elevated, including SCARB2, a host cell receptor protein involved in virus entry. A comparison with the plasma protein response in patients with severe symptoms shows a highly similar pattern, but with some interesting differences.\n\nThe study presented here demonstrates the usefulness of \"next generation plasma protein profiling\" to identify molecular signatures of importance for disease progression and to allow monitoring of disease during recovery from the infection. The results will facilitate further studies to understand the molecular mechanism of the immune-related response of the SARS-CoV-2 virus.\n\nThis work was financially supported by Knut and Alice Wallenberg Foundation.", "doi": "10.1016/j.ebiom.2021.103723", "pmid": "34844191", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8626206"}, {"db": "pii", "key": "S2352-3964(21)00517-X"}], "notes": [], "created": "2021-12-18T18:11:33.370Z", "modified": "2023-06-19T15:39:44.480Z"}, {"entity": "publication", "iuid": "635551968c97474e8cc1a35c1be3193d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/635551968c97474e8cc1a35c1be3193d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/635551968c97474e8cc1a35c1be3193d"}}, "title": "National health governance, science and the media: drivers of COVID-19 responses in Germany, Sweden and the UK in 2020.", "authors": [{"family": "Hanson", "given": "Claudia", "initials": "C", "orcid": "0000-0001-8066-7873", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c06a2e703c840788ccdf3b2c4c972bc.json"}}, {"family": "Luedtke", "given": "Susanne", "initials": "S"}, {"family": "Spicer", "given": "Neil", "initials": "N"}, {"family": "Stilhoff S\u00f6rensen", "given": "Jens", "initials": "J"}, {"family": "Mayhew", "given": "Susannah", "initials": "S"}, {"family": "Mounier-Jack", "given": "Sandra", "initials": "S"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "12", "issn-l": "2059-7908"}, "abstract": "The COVID-19 pandemic is an unprecedented global crisis in which governments had to act in a situation of rapid change and substantial uncertainty. The governments of Germany, Sweden and the UK have taken different paths allowing learning for future pandemic preparedness. To help inform discussions on preparedness, inspired by resilience frameworks, this paper reviews governance structures, and the role of science and the media in the COVID-19 response of Germany, Sweden and the UK in 2020. We mapped legitimacy, interdependence, knowledge generation and the capacity to deal with uncertainty.Our analysis revealed stark differences which were linked to pre-existing governing structures, the traditional role of academia, experience of crisis management and the communication of uncertainty-all of which impacted on how much people trusted their government. Germany leveraged diversity and inclusiveness, a 'patchwork quilt', for which it was heavily criticised during the second wave. The Swedish approach avoided plurality and largely excluded academia, while in the UK's academia played an important role in knowledge generation and in forcing the government to review its strategies. However, the vivant debate left the public with confusing and rapidly changing public health messages. Uncertainty and the lack of evidence on how best to manage the COVID-19 pandemic-the main feature during the first wave-was only communicated explicitly in Germany. All country governments lost trust of their populations during the epidemic due to a mix of communication and transparency failures, and increased questioning of government legitimacy and technical capacity by the public.", "doi": "10.1136/bmjgh-2021-006691", "pmid": "34872972", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8764706"}, {"db": "pii", "key": "bmjgh-2021-006691"}], "notes": [], "created": "2021-12-12T07:10:21.949Z", "modified": "2023-01-13T13:28:12.610Z"}, {"entity": "publication", "iuid": "a957c1c71ff2471b879730385ff59136", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a957c1c71ff2471b879730385ff59136.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a957c1c71ff2471b879730385ff59136"}}, "title": "More than 50 long-term effects of COVID-19: a systematic review and meta-analysis", "authors": [{"family": "Lopez-Leon", "given": "Sandra", "initials": "S", "orcid": "0000-0001-7504-3441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/311cfec51fe9447283ee5c3a4ca0a3cd.json"}}, {"family": "Wegman-Ostrosky", "given": "Talia", "initials": "T", "orcid": "0000-0002-3207-6697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ebacfc4db6e4a04aab46b7172d828f2.json"}}, {"family": "Perelman", "given": "Carol", "initials": "C", "orcid": "0000-0002-0111-1154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb4874d2c45c4d698c57f5e3705d306d.json"}}, {"family": "Sepulveda", "given": "Rosalinda", "initials": "R", "orcid": "0000-0003-1146-9552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e217c9ab8c24eeca127ffb1dd89b843.json"}}, {"family": "Rebolledo", "given": "Paulina A", "initials": "PA", "orcid": "0000-0002-9808-063X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bbee43f79e147b39028119e0b573c72.json"}}, {"family": "Cuapio", "given": "Angelica", "initials": "A", "orcid": "0000-0002-9451-1914", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f4915fdfa7d460f9b705b56b0fc1c4a.json"}}, {"family": "Villapol", "given": "Sonia", "initials": "S", "orcid": "0000-0002-6174-4113", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04eb73dcc16546b0b153a41bcba039af.json"}}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": null}, "abstract": null, "doi": "10.1038/s41598-021-95565-8", "pmid": null, "labels": {"Type: Preprint": null, "Type: Review": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-17T19:33:26.821Z", "modified": "2022-07-06T04:52:15.537Z"}, {"entity": "publication", "iuid": "508d0a8b8a5a4f6684354585ced2f945", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/508d0a8b8a5a4f6684354585ced2f945.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/508d0a8b8a5a4f6684354585ced2f945"}}, "title": "Measuring changes in alcohol use in Finland and Norway during the COVID-19 pandemic: Comparison between data sources.", "authors": [{"family": "M\u00e4kel\u00e4", "given": "Pia", "initials": "P", "orcid": "0000-0002-3343-2139", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c978b04d84144cb694a974c01022890b.json"}}, {"family": "Rossow", "given": "Ingeborg", "initials": "I", "orcid": "0000-0001-8652-9367", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab426c14c36143d0bd2da8eb86f74e97.json"}}, {"family": "Moan", "given": "Inger Synn\u00f8ve", "initials": "IS", "orcid": "0000-0002-9021-8665", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fd744b5fb9f46e6868ab5b624ce81e4.json"}}, {"family": "Bye", "given": "Elin K", "initials": "EK", "orcid": "0000-0001-7559-8885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98e8956f35d94c1c8142605e7cdb51f7.json"}}, {"family": "Kilian", "given": "Carolin", "initials": "C", "orcid": "0000-0001-5913-6488", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed0409bb90b346cd9001bebb46bdcf87.json"}}, {"family": "Raitasalo", "given": "Kirsimarja", "initials": "K", "orcid": "0000-0001-7909-8562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28001f1928d44b98af9bd7d509477ae3.json"}}, {"family": "Allebeck", "given": "Peter", "initials": "P", "orcid": "0000-0002-2778-6467", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de9f0e1c3e4d402b93e61ad1c5a771fb.json"}}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Int J Methods Psychiatr Res", "issn": "1557-0657", "issn-l": null, "volume": "30", "issue": "4", "pages": "e1892"}, "abstract": "To examine (1) how a rapid data collection using a convenience sample fares in estimating change in alcohol consumption when compared to more conventional data sources, and (2) how alcohol consumption changed in Finland and Norway during the first months of the COVID-19 pandemic.\n\nThree different types of data sources were used for the 2nd quarter of 2020 and 2019: sales statistics combined with data on unrecorded consumption; the rapid European Alcohol Use and COVID-19 (ESAC) survey (Finland: n = 3800, Norway: n = 17,092); and conventional population surveys (Finland: n = 2345, Norway: n1 = 1328, n2 = 2189, n3 = 25,708). Survey measures of change were retrospective self-reports.\n\nThe statistics indicate that alcohol consumption decreased in Finland by 9%, while little change was observed in Norway. In all surveys, reporting a decrease in alcohol use was more common than reporting an increase (ratios 2-2.6 in Finland, 1.3-2 in Norway). Compared to conventional surveys, in the ESAC survey fewer respondents reported no change and past-year alcohol consumption was higher.\n\nThe rapid survey using convenience sampling gave similar results on change in drinking as conventional surveys but higher past-year drinking, suggesting self-selection effects. Aspects of the pandemic driving alcohol consumption down were equally strong or stronger than those driving it up.", "doi": "10.1002/mpr.1892", "pmid": "34449127", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8633923"}], "notes": [], "created": "2021-09-01T07:29:54.053Z", "modified": "2023-06-19T07:32:29.877Z"}, {"entity": "publication", "iuid": "e3b9bb4510224866b575e818109cc8b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3b9bb4510224866b575e818109cc8b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3b9bb4510224866b575e818109cc8b0"}}, "title": "Mapping the human genetic architecture of COVID-19.", "authors": [{"family": "COVID-19 Host Genetics Initiative", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Nature", "issn": "1476-4687", "issn-l": "0028-0836", "volume": "600", "issue": "7889", "pages": "472-477"}, "abstract": "The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3-7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.", "doi": "10.1038/s41586-021-03767-x", "pmid": "34237774", "labels": {"Funder: VR": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Research Area: Vaccine": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41586-021-03767-x"}, {"db": "pmc", "key": "PMC8674144"}], "notes": [], "created": "2021-08-06T10:53:44.989Z", "modified": "2022-02-06T17:38:20.820Z"}, {"entity": "publication", "iuid": "b8e256df3ccd48239acb1ee143624cfb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8e256df3ccd48239acb1ee143624cfb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8e256df3ccd48239acb1ee143624cfb"}}, "title": "Managers of micro-sized enterprises and Covid-19: impact on business operations, work-life balance and well-being.", "authors": [{"family": "Vinberg", "given": "Stig", "initials": "S", "orcid": "0000-0002-5935-5688", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c63c4ca58d242d18741dba0b0af5afb.json"}}, {"family": "Danielsson", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Int J Circumpolar Health", "issn": "2242-3982", "volume": "80", "issue": "1", "pages": "1959700", "issn-l": null}, "abstract": "The aim of this study is to identify how managers of micro-sized enterprises experience the impact of the Covid-19 pandemic on their business operations, work-life balance and well-being. Further, the study aims to make comparisons between managers of micro-sized businesses and managers of small-sized businesses. This mixed-method study is based on qualitative interviews with ten managers of micro-sized enterprises and a questionnaire answered by 95 managers of micro-sized and small-sized enterprises in regions in the north of Sweden. Managers of micro-sized enterprises reported significantly worse scores for mental well-being, job satisfaction and life satisfaction in comparison with managers of small-sized enterprises. Three themes emerged from the qualitative analysis: Changed leadership role, Impact on private life and Impact on well-being. In the interviews, the managers of micro-sized enterprises reported that the pandemic had increased their workload and forced them to mobilise strategies for enterprise survival. This study indicates that managers of micro-sized enterprises had changed their leadership role and increased their workload and number of work tasks, including supporting the employees, developing strategies for business survival and applying for governmental support. However, the managers demonstrated creativity in finding new solutions for their enterprises.", "doi": "10.1080/22423982.2021.1959700", "pmid": "34378496", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-08-12T17:06:29.217Z", "modified": "2021-08-12T17:08:20.118Z"}, {"entity": "publication", "iuid": "ea0c1b175467424bbc1e77816c8aa57d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ea0c1b175467424bbc1e77816c8aa57d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ea0c1b175467424bbc1e77816c8aa57d"}}, "title": "Insecurity, lack of support, and frustration: A sociological analysis of how three groups of students reflect on their distance education during the pandemic in Sweden.", "authors": [{"family": "Lidegran", "given": "Ida", "initials": "I", "orcid": "0000-0003-3193-5565", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d260c6beaac7465ea0a6c426ee30008f.json"}}, {"family": "Hultqvist", "given": "Elisabeth", "initials": "E"}, {"family": "Bertilsson", "given": "Emil", "initials": "E"}, {"family": "B\u00f6rjesson", "given": "Mikael", "initials": "M"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Eur J Educ", "issn": "1465-3435", "issn-l": null, "volume": "56", "issue": "4", "pages": "550-563"}, "abstract": "This article investigates the situation of Swedish upper secondary school students who have been subject to distance education during the COVID-19 pandemic crisis. We understand the transition from onsite education to distance education as a recontextualization of pedagogical practice, our framing follows loosely concepts from Bernstein. Given that the field of upper secondary education is highly socially structured it is relevant to enquire into the social dimensions of distance education. For this purpose, we have analysed answers to an open-ended question in a survey answered by 3,726 students, and related them to a cluster analysis distinguishing three main clusters of students: urban upper-middle-class, immigrant working-class, and rural working-class. The urban upper-middle-class students experienced problems decoding new requirements and were troubled by blurred boundaries between school and home. This group invests the most in schooling, and therefore expresses comparatively more anxiety for reaching anticipated achievements. Immigrant working-class students were comparatively more discontented by a lack of school support and request clearer instructions. In this new educational situation, characterized by a weak framing, they have difficulties decoding the requirements. The rural working-class students appear comparatively more disconnected from the school situation. Unlike urban upper-middle-class students, for whom the school invades the home and private sphere, the rural working-class students seldom experienced that the school intruded their home; accordingly, their studies collapsed into sleep-in-mornings and a holiday feeling.", "doi": "10.1111/ejed.12477", "pmid": "34898738", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "EJED12477"}, {"db": "pmc", "key": "PMC8646562"}], "notes": [], "created": "2021-12-18T18:00:37.973Z", "modified": "2022-11-22T05:44:45.823Z"}, {"entity": "publication", "iuid": "086c3c198dec478c9ddc11bc755e5ff8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/086c3c198dec478c9ddc11bc755e5ff8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/086c3c198dec478c9ddc11bc755e5ff8"}}, "title": "Initial assessment of the COVID-19 vaccination's impact on case numbers, hospitalisations and deaths in people aged 80 years and older, 15 EU/EEA countries, December 2020 to May 2021.", "authors": [{"family": "Nicolay", "given": "Nathalie", "initials": "N"}, {"family": "Innocenti", "given": "Francesco", "initials": "F"}, {"family": "Beaut\u00e9", "given": "Julien", "initials": "J"}, {"family": "U\u010dakar", "given": "Veronika", "initials": "V"}, {"family": "Grgi\u010d Vitek", "given": "Marta", "initials": "M"}, {"family": "Poukka", "given": "Eero", "initials": "E"}, {"family": "Hannila-Handelberg", "given": "Tuula", "initials": "T"}, {"family": "Gauci", "given": "Charmaine", "initials": "C"}, {"family": "Melillo", "given": "Tanya", "initials": "T"}, {"family": "Georgakopoulou", "given": "Theano", "initials": "T"}, {"family": "Jarkovsky", "given": "Jiri", "initials": "J"}, {"family": "Slezak", "given": "Pavel", "initials": "P"}, {"family": "Delgado-Sanz", "given": "Concepci\u00f3n", "initials": "C"}, {"family": "Olmedo-Lucer\u00f3n", "given": "Carmen", "initials": "C"}, {"family": "Suija", "given": "Heleene", "initials": "H"}, {"family": "Liausediene", "given": "Rasa", "initials": "R"}, {"family": "O'Lorcain", "given": "Piaras", "initials": "P"}, {"family": "Murphy", "given": "Niamh", "initials": "N"}, {"family": "Peralta-Santos", "given": "Andr\u00e9", "initials": "A"}, {"family": "Casaca", "given": "Pedro", "initials": "P"}, {"family": "Gregoriou", "given": "Ioanna", "initials": "I"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Spiteri", "given": "Gianfranco", "initials": "G"}, {"family": "Ravasi", "given": "Giovanni", "initials": "G"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "48", "issn-l": null}, "abstract": "Prioritisation of elderly people in COVID-19 vaccination campaigns aimed at reducing severe outcomes in this group. Using EU/EEA surveillance and vaccination uptake, we estimated the risk ratio of case, hospitalisation and death notifications in people 80 years and older compared with 25-59-year-olds. Highest impact was observed for full vaccination uptake 80% or higher with reductions in notification rates of cases up to 65% (IRR: 0.35; 95% CI: 0.13-0.99), hospitalisations up to 78% (IRR: 0.22; 95% CI: 0.13-0.37) and deaths up to 84% (IRR: 0.16; 95% CI: 0.13-0.20).", "doi": "10.2807/1560-7917.ES.2021.26.48.2101030", "pmid": "34857068", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8641072"}], "notes": [], "created": "2021-12-18T18:07:47.120Z", "modified": "2021-12-18T18:07:47.135Z"}, {"entity": "publication", "iuid": "9288b382d01b42629711ac1c5ae10c9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9288b382d01b42629711ac1c5ae10c9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9288b382d01b42629711ac1c5ae10c9c"}}, "title": "Human papillomavirus vaccination in the European Union/European Economic Area and globally: a moral dilemma.", "authors": [{"family": "Colzani", "given": "Edoardo", "initials": "E"}, {"family": "Johansen", "given": "Kari", "initials": "K"}, {"family": "Johnson", "given": "Helen", "initials": "H"}, {"family": "Pastore Celentano", "given": "Lucia", "initials": "L"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "50", "issn-l": null}, "abstract": "While many European Union/European Economic Area (EU/EEA) countries recently expanded human papillomavirus (HPV) vaccination to boys, HPV vaccine supply is currently limited for girls in low- and middle-income countries (LMIC) that are severely affected by HPV.Globally, about 50% of countries have introduced HPV vaccination. Some LMIC with high burden of cervical cancer have not yet introduced HPV vaccination, or are reaching suboptimal vaccination coverage. While WHO issued a call for cervical cancer elimination in 2018, a global shortage of HPV vaccines is currently predicted to last at least until 2024.We reviewed national policies of EU/EEA countries and recommendations of the World Health Organization (WHO) Strategic Advisory Group of Experts on immunisation to discuss current challenges and dose-sparing options. Several EU/EEA countries have extended HPV vaccination to boys and the European Cancer Organisation has issued a resolution for elimination of all HPV-associated cancers in both sexes. The European Centre for Disease Prevention and Control concluded in its 2020 guidance that cost-effectiveness of extending routine vaccination to boys depends on several context-specific factors. The extension of HPV vaccination to boys in EU/EEA countries may affect global availability of vaccines. Temporary dose-sparing options could be considered during the COVID-19 post-pandemic period.", "doi": "10.2807/1560-7917.ES.2021.26.50.2001659", "pmid": "34915976", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T17:44:17.021Z", "modified": "2021-12-18T17:44:17.034Z"}, {"entity": "publication", "iuid": "5d377c22678c463fb0fcddfaf34db158", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d377c22678c463fb0fcddfaf34db158.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d377c22678c463fb0fcddfaf34db158"}}, "title": "Epidemiological characterisation of the first 785 SARS-CoV-2 Omicron variant cases in Denmark, December 2021.", "authors": [{"family": "Espenhain", "given": "Laura", "initials": "L"}, {"family": "Funk", "given": "Tjede", "initials": "T"}, {"family": "Overvad", "given": "Maria", "initials": "M"}, {"family": "Edslev", "given": "Sofie Marie", "initials": "SM"}, {"family": "Fonager", "given": "Jannik", "initials": "J"}, {"family": "Ingham", "given": "Anna C\u00e4cilia", "initials": "AC"}, {"family": "Rasmussen", "given": "Morten", "initials": "M"}, {"family": "Madsen", "given": "Sarah Leth", "initials": "SL"}, {"family": "Espersen", "given": "Caroline Hjorth", "initials": "CH"}, {"family": "Sieber", "given": "Raphael N", "initials": "RN"}, {"family": "Stegger", "given": "Marc", "initials": "M"}, {"family": "Gunalan", "given": "Vithiagaran", "initials": "V"}, {"family": "Wilkowski", "given": "Bartlomiej", "initials": "B"}, {"family": "Larsen", "given": "Nicolai Balle", "initials": "NB"}, {"family": "Legarth", "given": "Rebecca", "initials": "R"}, {"family": "Cohen", "given": "Arieh Sierra", "initials": "AS"}, {"family": "Nielsen", "given": "Finn", "initials": "F"}, {"family": "Lam", "given": "Janni Uyen Hoa", "initials": "JUH"}, {"family": "Lavik", "given": "Kjetil Erdogan", "initials": "KE"}, {"family": "Karakis", "given": "Marianne", "initials": "M"}, {"family": "Spiess", "given": "Katja", "initials": "K"}, {"family": "Marving", "given": "Ellinor", "initials": "E"}, {"family": "Nielsen", "given": "Christian", "initials": "C"}, {"family": "Wiid Svarrer", "given": "Christina", "initials": "C"}, {"family": "Bybjerg-Grauholm", "given": "Jonas", "initials": "J"}, {"family": "Olsen", "given": "Stefan Schytte", "initials": "SS"}, {"family": "Jensen", "given": "Anders", "initials": "A"}, {"family": "Krause", "given": "Tyra Grove", "initials": "TG"}, {"family": "M\u00fcller", "given": "Luise", "initials": "L"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "50", "issn-l": null}, "abstract": "By 9 December 2021, 785 SARS-CoV-2 Omicron variant cases have been identified in Denmark. Most cases were fully (76%) or booster-vaccinated (7.1%); 34 (4.3%) had a previous SARS-CoV-2 infection. The majority of cases with available information reported symptoms (509/666; 76%) and most were infected in Denmark (588/644; 91%). One in five cases cannot be linked to previous cases, indicating widespread community transmission. Nine cases have been hospitalised, one required intensive care and no deaths have been registered.", "doi": "10.2807/1560-7917.ES.2021.26.50.2101146", "pmid": "34915977", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T17:42:47.527Z", "modified": "2021-12-18T17:42:47.539Z"}, {"entity": "publication", "iuid": "ce16ae5550dd4daf93f8efb4d2fe95dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ce16ae5550dd4daf93f8efb4d2fe95dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ce16ae5550dd4daf93f8efb4d2fe95dd"}}, "title": "Digital media content and co-viewing amongst Swedish 4- to 6-year-olds during COVID-19 pandemic.", "authors": [{"family": "Sundqvist", "given": "Annette", "initials": "A", "orcid": "0000-0001-9611-6523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1ee75c32ea3490d9c8f4f8d60c1005a.json"}}, {"family": "Heimann", "given": "Mikael", "initials": "M", "orcid": "0000-0001-5025-9975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58e5802e62bb41f28642119aab148b35.json"}}], "type": "letter", "published": "2021-12-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": "110", "issue": "12", "pages": "3329-3330"}, "abstract": "COVID-19 restrictions have increased the use of digital media and studies have suggested that children's screen time has increased by 10 hours a week since the pandemic.1 However, screen time is a very basic measure and it is also important to consider the content and context of digital media. Digital media may have negative effects on behaviour, language and memory,2,3 but this may be moderated by the positive effects of joint media engagement between children and their parents.", "doi": "10.1111/apa.16090", "pmid": "34469600", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC8653155"}], "notes": [], "created": "2021-09-06T15:53:34.789Z", "modified": "2023-06-19T14:54:35.006Z"}, {"entity": "publication", "iuid": "c42cd7518bcc45228097ec02379a869e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c42cd7518bcc45228097ec02379a869e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c42cd7518bcc45228097ec02379a869e"}}, "title": "Differences in risk for SARS-CoV-2 infection among healthcare workers", "authors": [{"family": "Elfstr\u00f6m", "given": "K Miriam", "initials": "KM"}, {"family": "Blomqvist", "given": "Jonas", "initials": "J"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Pimenoff", "given": "Ville N", "initials": "VN", "orcid": "0000-0002-0813-7031", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6df74f265514d7b8fa216d9bad0ead6.json"}}, {"family": "Arroyo M\u00fchr", "given": "Laila Sara", "initials": "LS"}, {"family": "Lundgren", "given": "Kalle Conneryd", "initials": "KC"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "Prev Med Rep", "issn": "2211-3355", "issn-l": null, "volume": "24", "issue": null, "pages": "101518"}, "abstract": "Healthcare workers (HCWs) are a risk group for SARS-CoV-2 infection, but which healthcare work that conveys risk and to what extent such risk can be prevented is not clear. Starting on April 24th, 2020, all employees at work (n = 15,300) at the Karolinska University Hospital, Stockholm, Sweden were invited and 92% consented to participate in a SARS-CoV-2 cohort study. Complete SARS-CoV-2 serology was available for n = 12,928 employees and seroprevalences were analyzed by age, sex, profession, patient contact, and hospital department. Relative risks were estimated to examine the association between type of hospital department as a proxy for different working environment exposure and risk for seropositivity, adjusting for age, sex, sampling week, and profession. Wards that were primarily responsible for COVID-19 patients were at increased risk (adjusted OR 1.95 (95% CI 1.65-2.32) with the notable exception of the infectious diseases and intensive care units (adjusted OR 0.86 (95% CI 0.66-1.13)), that were not at increased risk despite being highly exposed. Several units with similar types of work varied greatly in seroprevalences. Among the professions examined, nurse assistants had the highest risk (adjusted OR 1.62 (95% CI 1.38-1.90)). Although healthcare workers, in particular nurse assistants, who attend to COVID-19 patients are a risk group for SARS-CoV-2 infection, several units caring for COVID-19 patients had no excess risk. Large variations in seroprevalences among similar units suggest that healthcare work-related risk of SARS-CoV-2 infection may be preventable.", "doi": "10.1016/j.pmedr.2021.101518", "pmid": "34458081", "labels": {"Funder: KAW/SciLifeLab": null, "Category: Health": null, "Research Area: High-throughput and high-content serology": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2211-3355(21)00208-4"}, {"db": "pmc", "key": "PMC8379088"}], "notes": [], "created": "2021-04-10T07:52:23.920Z", "modified": "2022-02-06T17:35:15.389Z"}, {"entity": "publication", "iuid": "da5951f63d5744ed9f8e6bb8a6b7df0c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/da5951f63d5744ed9f8e6bb8a6b7df0c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/da5951f63d5744ed9f8e6bb8a6b7df0c"}}, "title": "Depression, anxiety and suicidal behaviour among college students: Comparisons pre-COVID-19 and during the pandemic.", "authors": [{"family": "McLafferty", "given": "Margaret", "initials": "M"}, {"family": "Brown", "given": "Natasha", "initials": "N"}, {"family": "McHugh", "given": "Rachel", "initials": "R"}, {"family": "Ward", "given": "Caoimhe", "initials": "C"}, {"family": "Stevenson", "given": "Ailis", "initials": "A"}, {"family": "McBride", "given": "Louise", "initials": "L"}, {"family": "Brady", "given": "John", "initials": "J"}, {"family": "Bjourson", "given": "Anthony J", "initials": "AJ"}, {"family": "O'Neill", "given": "Siobhan M", "initials": "SM"}, {"family": "Walsh", "given": "Colum P", "initials": "CP"}, {"family": "Murray", "given": "Elaine K", "initials": "EK"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Psychiatry Res Commun", "issn": "2772-5987", "volume": "1", "issue": "2", "pages": "100012", "issn-l": null}, "abstract": "Many students struggle with psychological problems during their college years. These problems may be even more apparent during the COVID-19 pandemic with the accompanying restrictions and transition to an online learning environment, but few longitudinal studies have been conducted to date. The aim of this study was to compare symptoms of depression, anxiety and suicidality prior to and during the pandemic, and identify stressors.\n\nThis study was conducted among students attending Ulster University, Northern Ireland (NI) and LYIT, Republic of Ireland (ROI), as part of the World Mental Health International College Student Initiative (WMH-ICS). Data was collected from first year students in September 2019. The completed response rate was 25.22% (NI) and 41.9% (ROI) in relation to the number of first-year students registered. A follow up study was conducted in Autumn 2020, with 884 students fully completing the online survey in both years, equating to just under half of those who completed initially.\n\nHigh levels of mental health problems were found in year 1, especially in the ROI. Levels of depression increased significantly in year 2, particularly among students in NI, however, levels of anxiety decreased. No significant variations were found for suicidal behaviour. Several stressors were revealed, including increased social isolation, and worrying about loved ones.\n\nThe findings may not be generalised to other student populations.\n\nThis study reveals variation in symptoms of depression and anxiety since the onset of the pandemic. In particular, the large increase in students with depression is of concern.", "doi": "10.1016/j.psycom.2021.100012", "pmid": "34977911", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2772-5987(21)00012-X"}, {"db": "pmc", "key": "PMC8574925"}], "notes": [], "created": "2022-01-04T14:43:28.782Z", "modified": "2022-01-04T14:43:28.821Z"}, {"entity": "publication", "iuid": "7b60e6c3be494a6c9e59e8b83866fa06", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b60e6c3be494a6c9e59e8b83866fa06.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b60e6c3be494a6c9e59e8b83866fa06"}}, "title": "Clinical outcomes in cancer patients with COVID-19 in Sweden.", "authors": [{"family": "Bondeson", "given": "Lisa", "initials": "L"}, {"family": "Thulin", "given": "Anna", "initials": "A"}, {"family": "Ny", "given": "Lars", "initials": "L", "orcid": "0000-0003-3864-5958", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/861e0a04f51e453ca92d6cca8624e187.json"}}, {"family": "Levin", "given": "Max", "initials": "M"}, {"family": "Svensson", "given": "Johanna", "initials": "J"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Zhao", "given": "Zhiyuan", "initials": "Z", "orcid": "0000-0002-6962-1791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/540e3389bb044d9991e81a68320dd224.json"}}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Acta Oncol", "issn": "1651-226X", "pages": "1572-1579", "volume": "60", "issue": "12", "issn-l": null}, "abstract": "The results of studies on the relationship between cancer and COVID-19 have been conflicting and therefore further studies are needed. We aimed to examine the incidence of COVID-19 among patients at one of the largest oncology departments in Sweden, and to evaluate and identify risk factors for poor outcomes, hospital care and death, associated with COVID-19 among cancer patients.\n\nThis retrospective study included cancer patients at a single center who tested positive for SARS-CoV-2 by PCR either in hospital, primary health care center or commercial laboratory between 1 March and 14 August 2020. Clinical and demographic data were collected from the medical records. Logistic regression analysis was used to identify variables that associated the primary outcomes of need for hospital care and death within 30 days of positive test.\n\nOf 10,774 patients from the Department of Oncology at Sahlgrenska University Hospital, 135 tested positive for SARS-CoV-2 (1.3%). Twenty-eight patients were excluded from further the data collection since they did not meet the inclusion criteria. Altogether, 107 cancer patients were included and the case fatality rate (CFR) was 12% (13) within 30 days of confirmed SARS-CoV-2 infection by PCR. Increasing years of age (OR 1.10; CI 95% 1.03-1.18), palliative treatment intent (OR 15.7; CI 95% 1.8-135.8), and transition to end-of-life care (OR 52.0; CI 95% 3.7-735.6) were associated with increased odds of death within 30 days. Male sex was associated with needing hospital care (OR 3.7; CI 95% 1.50-9.1).\n\nAs in the general population, male sex was found to be at greater risk of needing hospital care for COVID-19, with terminal cancer disease, and older age increasing the odds of fatality. Compared to the general population, slightly more cancer patients had COVID-19. The CFR was within the lower range of others reported in cancer patients.", "doi": "10.1080/0284186X.2021.1973679", "pmid": "34530692", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-09-20T16:54:02.162Z", "modified": "2023-01-13T13:30:58.420Z"}, {"entity": "publication", "iuid": "cad95e26023141d3a2014a198a44eea6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cad95e26023141d3a2014a198a44eea6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cad95e26023141d3a2014a198a44eea6"}}, "title": "Characteristics and definitive outcomes of COVID-19 patients admitted to a secondary hospital intensive care unit in Sweden.", "authors": [{"family": "Sj\u00f6str\u00f6m", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-5671-2563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7135a88659334a8eba1250f0caa3941c.json"}}, {"family": "M\u00e5nsson", "given": "Emeli", "initials": "E"}, {"family": "Viklund Kamienny", "given": "Josefin", "initials": "J"}, {"family": "\u00d6stberg", "given": "Erland", "initials": "E"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Health Sci Rep", "issn": "2398-8835", "volume": "4", "issue": "4", "pages": "e446", "issn-l": null}, "abstract": "Most published reports of COVID-19 Intensive Care Unit (ICU) patients are from large tertiary hospitals and often present short-term or incomplete outcome data. There are reports indicating that ICUs with fewer beds are associated with higher mortality. This study aimed to investigate the definitive outcome and patient characteristics of the complete first wave of COVID-19 patients admitted to ICU in a secondary hospital.\n\nIn this prospective observational study, all patients with respiratory failure and a positive SARS-CoV-2 test admitted to V\u00e4ster\u00e5s Hospital ICU between 24 March and July 22, 2020 were included. The primary outcome was defined as 90-day mortality. Secondary outcomes included ICU length of stay, hospital length of stay, number of days with invasive ventilation, need for vasopressors/inotropes, and use of renal replacement therapy.\n\nFifty-three patients were included. Median age (range) was 59 (33-76) and 74% were men. Obesity and hypertension were the most common comorbidities and 45% of the patients were born outside Europe. Ninety-day mortality was 30%. Median ICU length of stay (interquartile range) was 14 (5-24) days and the duration of invasive mechanical ventilation 16 (12-26) days. No patients received dialysis at 90-day follow-up.\n\nIn this cohort of COVID-19 patients treated in a secondary hospital ICU, mortality rates were low compared to early studies from China, Italy, and the United States, but similar to other government-funded hospitals in Scandinavia. A preparatory reorganization enabled an increase in ICU capacity, hence avoiding an overwhelmed intensive care organization.", "doi": "10.1002/hsr2.446", "pmid": "34938894", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "HSR2446"}, {"db": "pmc", "key": "PMC8670731"}], "notes": [], "created": "2022-01-03T15:34:46.050Z", "modified": "2022-01-03T15:34:46.133Z"}, {"entity": "publication", "iuid": "34c0583ae1ea4e0c83bb5bac2f979093", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/34c0583ae1ea4e0c83bb5bac2f979093.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/34c0583ae1ea4e0c83bb5bac2f979093"}}, "title": "COVID-19 trends and severity among symptomatic children aged 0-17 years in 10 European Union countries, 3 August 2020 to 3 October 2021.", "authors": [{"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Dave", "given": "Nishi", "initials": "N"}, {"family": "Pharris", "given": "Anastasia", "initials": "A"}, {"family": "Spiteri", "given": "Gianfranco", "initials": "G"}, {"family": "Deogan", "given": "Charlotte", "initials": "C"}, {"family": "Suk", "given": "Jonathan E", "initials": "JE"}, {"family": "Study group members", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "50", "issn-l": null}, "abstract": "We estimated risks of severe outcomes in 820,404 symptomatic paediatric COVID-19 cases reported by 10 European Union countries between August 2020 and October 2021. Case and hospitalisation rates rose as transmission increased but severe outcomes were rare: 9,611 (1.2%) were hospitalised, 640 (0.08%) required intensive care and 84 (0.01%) died. Despite increased individual risk (adjusted odds ratio hospitalisation: 7.3; 95% confidence interval: 3.3-16.2; intensive care: 8.7; 6.2-12.3) in cases with comorbidities, most (83.7%) hospitalised children had no comorbidity.", "doi": "10.2807/1560-7917.ES.2021.26.50.2101098", "pmid": "34915968", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T17:44:33.895Z", "modified": "2021-12-18T17:44:33.907Z"}, {"entity": "publication", "iuid": "09c78ca7f2f44a6f8173de8e305a5ff5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/09c78ca7f2f44a6f8173de8e305a5ff5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/09c78ca7f2f44a6f8173de8e305a5ff5"}}, "title": "COVID-19 is Associated with an Acquired Factor XIII Deficiency.", "authors": [{"family": "von Meijenfeldt", "given": "Fien A", "initials": "FA"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Adelmeijer", "given": "Jelle", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Thalin", "given": "Charlotte", "initials": "C"}, {"family": "Lisman", "given": "Ton", "initials": "T"}], "type": "letter", "published": "2021-12-00", "journal": {"title": "Thromb Haemost", "issn": "2567-689X", "issn-l": "0340-6245", "volume": "121", "issue": "12", "pages": "1668-1669"}, "abstract": "No Abstract.", "doi": "10.1055/a-1450-8414", "pmid": "33742434", "labels": {"Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-22T10:28:03.488Z", "modified": "2022-02-06T17:15:14.074Z"}, {"entity": "publication", "iuid": "ac5fb4e2b68f4c5b8ee3a19341e6f046", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac5fb4e2b68f4c5b8ee3a19341e6f046.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac5fb4e2b68f4c5b8ee3a19341e6f046"}}, "title": "Asthma Diagnosis without Aerosol-Generating Procedures (Spirometry): Evidence for and Beyond the COVID-19 Pandemic", "authors": [{"family": "Kankaanranta", "given": "Hannu", "initials": "H"}, {"family": "Lehtim\u00e4ki", "given": "Lauri", "initials": "L"}, {"family": "Tuomisto", "given": "Leena E", "initials": "LE"}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "The Journal of Allergy and Clinical Immunology: In Practice", "issn": "2213-2198", "volume": "9", "issue": "12", "pages": "4252-4253", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jaip.2021.09.036", "pmid": null, "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:45:57.547Z", "modified": "2021-12-12T06:45:57.570Z"}, {"entity": "publication", "iuid": "460adc71009e4637b23139398f8c251a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/460adc71009e4637b23139398f8c251a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/460adc71009e4637b23139398f8c251a"}}, "title": "Appendicitis as a possible safety signal for the COVID-19 vaccines.", "authors": [{"family": "Mitchell", "given": "Joseph", "initials": "J"}, {"family": "Yue", "given": "Qun-Ying", "initials": "QY"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Vaccine X", "issn": "2590-1362", "volume": "9", "pages": "100122", "issn-l": null}, "abstract": "This study reviewed cases of appendicitis following administration of COVID-19 vaccines reported to VigiBase, the WHO database of individual case safety reports (ICSRs). Three hundred fifty-eight cases were identified, and disproportionate reporting was noted, with 329 calculated expected cases. Upon review, 24 ICSRs were excluded, so 334 unique ICSRs underwent clinical review from 19 countries. Forty-eight percent of ICSRs reported imaging and 69% noted surgical intervention. The cases were clinically coherent, with an apparent increase in reporting in the four days post-vaccination and a possible dose-response relationship. Appendicitis has been suggested as an adverse event of special interest post-vaccination against COVID-19 after a numerical increase in the vaccine arm of a clinical trial. The case series may be affected by differences in global patterns of reporting, and it is not possible to prove nor disprove causality from this case series. Global longitudinal studies are required to clarify any possible relationship.", "doi": "10.1016/j.jvacx.2021.100122", "pmid": "34746743", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2590-1362(21)00039-5"}, {"db": "pmc", "key": "PMC8565092"}], "notes": [], "created": "2021-11-26T15:34:13.902Z", "modified": "2021-11-26T15:34:26.952Z"}, {"entity": "publication", "iuid": "f7fbe5dff8494271a1aacb6195cf6751", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7fbe5dff8494271a1aacb6195cf6751.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7fbe5dff8494271a1aacb6195cf6751"}}, "title": "Angiotensin-Converting Enzyme 2 (SARS-CoV-2 receptor) expression in human skeletal muscle.", "authors": [{"family": "Perez-Valera", "given": "Mario", "initials": "M", "orcid": "0000-0002-8332-729X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35803b8f85964ce29760fbfad3aa06ac.json"}}, {"family": "Martinez-Canton", "given": "Miriam", "initials": "M", "orcid": "0000-0002-2925-3429", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77d454baf0894523ba5bc199eab7f95a.json"}}, {"family": "Gallego-Selles", "given": "Angel", "initials": "A", "orcid": "0000-0002-8068-9586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70d49ae713f2483fa618b92fbf1588d1.json"}}, {"family": "Galv\u00e1n-Alvarez", "given": "Victor", "initials": "V", "orcid": "0000-0002-1272-3471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f1c4f6e96b34be0a806da80c295efec.json"}}, {"family": "Gelabert-Rebato", "given": "Miriam", "initials": "M", "orcid": "0000-0002-8963-5568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0a3ce72669b4327b37c5a50bfc4e063.json"}}, {"family": "Morales-Alamo", "given": "David", "initials": "D", "orcid": "0000-0001-8463-397X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b9030289cfc412eb3ad0520a4f415fb.json"}}, {"family": "Santana", "given": "Alfredo", "initials": "A"}, {"family": "Martin-Rodriguez", "given": "Saul", "initials": "S", "orcid": "0000-0003-2423-5309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b26c4d0d7634deaa6a8869f40782e01.json"}}, {"family": "Ponce-Gonzalez", "given": "Jesus Gustavo", "initials": "JG", "orcid": "0000-0002-5982-7761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a276f5133dcc4bebb7bfae3939dd8f1b.json"}}, {"family": "Larsen", "given": "Steen", "initials": "S", "orcid": "0000-0002-5170-4337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c7e2c4f43b74b5ea6a52ec74ebb67ac.json"}}, {"family": "Losa-Reyna", "given": "Jose", "initials": "J", "orcid": "0000-0001-9545-5654", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/811b803c1ee749868f4b8ef94c82ded2.json"}}, {"family": "Perez-Suarez", "given": "Ismael", "initials": "I", "orcid": "0000-0002-7969-0061", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1ee30dc71c947028d55aecb45de60f3.json"}}, {"family": "Dorado", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-6616-6810", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db7e83e02066409988f34726d87735c5.json"}}, {"family": "Curtelin", "given": "David", "initials": "D", "orcid": "0000-0001-6462-382X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b9aecb9e275413a93fb0fc49b9198e6.json"}}, {"family": "Gonzalez-Henriquez", "given": "Juan Jose", "initials": "JJ", "orcid": "0000-0002-0622-5580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f66fd2bee3cd4391b23f6cba17aa7af3.json"}}, {"family": "Boushel", "given": "Robert", "initials": "R"}, {"family": "Hallen", "given": "Jostein", "initials": "J", "orcid": "0000-0002-6646-0734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8ad3bb0c71742dd95d6c584dc484254.json"}}, {"family": "de Pablos Velasco", "given": "Pedro", "initials": "P", "orcid": "0000-0002-9190-2581", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/951391585db9407bb6e42de7edb31c54.json"}}, {"family": "Freixinet-Gilart", "given": "Jorge", "initials": "J"}, {"family": "Holmberg", "given": "Hans-Christer", "initials": "HC", "orcid": "0000-0002-3814-6246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6325cd0a9474be49df847f6677f96bb.json"}}, {"family": "Helge", "given": "Jorn W", "initials": "JW", "orcid": "0000-0001-9724-5423", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0080b3aa65ce4d879c8c9c10e68b8d80.json"}}, {"family": "Martin-Rincon", "given": "Marcos", "initials": "M", "orcid": "0000-0002-3685-2331", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a26c0e8c2de4c07af458b07036369b4.json"}}, {"family": "Calbet", "given": "Jose A L", "initials": "JAL", "orcid": "0000-0002-9215-6234", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef57535cde26435ab75c47827f26bc48.json"}}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Scand J Med Sci Sports", "issn": "1600-0838", "issn-l": null, "volume": "31", "issue": "12", "pages": "2249-2258"}, "abstract": "The study aimed to determine the levels of skeletal muscle angiotensin-converting enzyme 2 (ACE2, the SARS-CoV-2 receptor) protein expression in men and women and assess whether ACE2 expression in skeletal muscle is associated with cardiorespiratory fitness and adiposity. The level of ACE2 in vastus lateralis muscle biopsies collected in previous studies from 170 men (age: 19-65 years, weight: 56-137 kg, BMI: 23-44) and 69 women (age: 18-55 years, weight: 41-126 kg, BMI: 22-39) was analyzed in duplicate by western blot. VO2 max was determined by ergospirometry and body composition by DXA. ACE2 protein expression was 1.8-fold higher in women than men (p = 0.001, n = 239). This sex difference disappeared after accounting for the percentage of body fat (fat %), VO2 max per kg of legs lean mass (VO2 max-LLM) and age (p = 0.47). Multiple regression analysis showed that the fat % (\u03b2 = 0.47) is the main predictor of the variability in ACE2 protein expression in skeletal muscle, explaining 5.2% of the variance. VO2 max-LLM had also predictive value (\u03b2 = 0.09). There was a significant fat % by VO2 max-LLM interaction, such that for subjects with low fat %, VO2 max-LLM was positively associated with ACE2 expression while as fat % increased the slope of the positive association between VO2 max-LLM and ACE2 was reduced. In conclusion, women express higher amounts of ACE2 in their skeletal muscles than men. This sexual dimorphism is mainly explained by sex differences in fat % and cardiorespiratory fitness. The percentage of body fat is the main predictor of the variability in ACE2 protein expression in human skeletal muscle.", "doi": "10.1111/sms.14061", "pmid": "34551157", "labels": {"Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8662278"}], "notes": [], "created": "2021-10-27T05:14:42.763Z", "modified": "2023-06-19T14:55:14.813Z"}, {"entity": "publication", "iuid": "efe78cba12754f37bbd373087552168b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/efe78cba12754f37bbd373087552168b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/efe78cba12754f37bbd373087552168b"}}, "title": "Alcohol consumption during the COVID-19 pandemic in Europe: a large-scale cross-sectional study in 21 countries.", "authors": [{"family": "Kilian", "given": "Carolin", "initials": "C", "orcid": "0000-0001-5913-6488", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed0409bb90b346cd9001bebb46bdcf87.json"}}, {"family": "Rehm", "given": "J\u00fcrgen", "initials": "J", "orcid": "0000-0001-5665-0385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83f5b8ddf5844eb6a1118d8ec4c4dca2.json"}}, {"family": "Allebeck", "given": "Peter", "initials": "P", "orcid": "0000-0002-2778-6467", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de9f0e1c3e4d402b93e61ad1c5a771fb.json"}}, {"family": "Braddick", "given": "Fleur", "initials": "F", "orcid": "0000-0001-6755-4567", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e9df2867269470ab43dd6802b5abb49.json"}}, {"family": "Gual", "given": "Antoni", "initials": "A", "orcid": "0000-0002-7130-981X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a9b53e2b8644056920e73b5b1d014d9.json"}}, {"family": "Bart\u00e1k", "given": "Miroslav", "initials": "M", "orcid": "0000-0002-7265-6514", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77e98268e4ef42f6a5a036b75d6a1c56.json"}}, {"family": "Bloomfield", "given": "Kim", "initials": "K", "orcid": "0000-0002-9740-126X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/17159b4979b74d4b81543e53c1e339ef.json"}}, {"family": "Gil", "given": "Artyom", "initials": "A", "orcid": "0000-0002-0548-5380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a39dedff1af2460a9053e78804085087.json"}}, {"family": "Neufeld", "given": "Maria", "initials": "M", "orcid": "0000-0001-6364-3765", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/641c0a90ba5c41ab904f9d1b8212b387.json"}}, {"family": "O'Donnell", "given": "Amy", "initials": "A", "orcid": "0000-0003-4071-9434", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ae93b46570e4fe092eb0dde1bf3edae.json"}}, {"family": "Petru\u017eelka", "given": "Benjamin", "initials": "B", "orcid": "0000-0003-0318-3589", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/135b991aff2a486cb76a4f362d85b5e6.json"}}, {"family": "Rogalewicz", "given": "Vladimir", "initials": "V", "orcid": "0000-0001-5432-4148", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/904dc3953e4e42d4ac5f317f7b3c5b36.json"}}, {"family": "Schulte", "given": "Bernd", "initials": "B", "orcid": "0000-0003-1139-030X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79c126298bdf42518d5d0384a7e1ec42.json"}}, {"family": "Manthey", "given": "Jakob", "initials": "J", "orcid": "0000-0003-1231-3760", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5e779db5bf14c38aad0f3a964b7d9bd.json"}}, {"family": "European Study Group on Alcohol Use and COVID-19", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Addiction", "issn": "1360-0443", "issn-l": null, "volume": "116", "issue": "12", "pages": "3369-3380"}, "abstract": "To investigate changes in alcohol consumption during the first months of the COVID-19 pandemic in Europe as well as its associations with income and experiences of distress related to the pandemic.\n\nCross-sectional on-line survey conducted between 24 April and 22 July 2020.\n\nTwenty-one European countries.\n\nA total of 31 964 adults reporting past-year drinking.\n\nChanges in alcohol consumption were measured by asking respondents about changes over the previous month in their drinking frequency, the quantity they consumed and incidence of heavy episodic drinking events. Individual indicators were combined into an aggregated consumption-change score and scaled to a possible range of -1 to +1. Using this score as the outcome, multi-level linear regressions tested changes in overall drinking, taking into account sampling weights and baseline alcohol consumption [Alcohol Use Disorder Identification Test (AUDIT-C)] and country of residence serving as random intercept. Similar models were conducted for each single consumption-change indicator.\n\nThe aggregated consumption-change score indicated an average decrease in alcohol consumption of -0.14 [95% confidence interval (CI) = -0.18, -0.10]. Statistically significant decreases in consumption were found in all countries, except Ireland (-0.08, 95% CI = -0.17, 0.01) and the United Kingdom (+0.10, 95% CI = 0.03, 0.17). Decreases in drinking were mainly driven by a reduced frequency of heavy episodic drinking events (-0.17, 95% CI = -0.20, -0.14). Declines in consumption were less marked among those with low- or average incomes and those experiencing distress.\n\nOn average, alcohol consumption appears to have declined during the first months of the COVID-19 pandemic in Europe. Both reduced availability of alcohol and increased distress may have affected consumption, although the former seems to have had a greater impact in terms of immediate effects.", "doi": "10.1111/add.15530", "pmid": "34109685", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-11T05:05:21.772Z", "modified": "2023-06-19T07:32:42.997Z"}, {"entity": "publication", "iuid": "196bb322291948ddb3242acd3929326f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/196bb322291948ddb3242acd3929326f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/196bb322291948ddb3242acd3929326f"}}, "title": "Acquired olfactory loss alters functional connectivity and morphology", "authors": [{"family": "Iravani", "given": "Behzad", "initials": "B"}, {"family": "Peter", "given": "Moa G", "initials": "MG"}, {"family": "Arshamian", "given": "Artin", "initials": "A"}, {"family": "Olsson", "given": "Mats J", "initials": "MJ"}, {"family": "Hummel", "given": "Thomas", "initials": "T"}, {"family": "Kitzler", "given": "Hagen H", "initials": "HH"}, {"family": "Lundstr\u00f6m", "given": "Johan N", "initials": "JN"}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": null}, "abstract": null, "doi": "10.1038/s41598-021-95968-7", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-15T15:48:22.155Z", "modified": "2022-07-06T06:58:18.400Z"}, {"entity": "publication", "iuid": "15f52e9d5ead4387aae6b6cd95392dae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15f52e9d5ead4387aae6b6cd95392dae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15f52e9d5ead4387aae6b6cd95392dae"}}, "title": "A population-based dataset concerning predictors of willingness to get a COVID-19 vaccine in Iran.", "authors": [{"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}, {"family": "Yahaghi", "given": "Rafat", "initials": "R"}, {"family": "Ahmadizade", "given": "Safie", "initials": "S"}, {"family": "Fotuhi", "given": "Razie", "initials": "R"}, {"family": "Taherkhani", "given": "Elham", "initials": "E"}, {"family": "Ranjbaran", "given": "Mehdi", "initials": "M"}, {"family": "Buchali", "given": "Zeinab", "initials": "Z"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Data Brief", "issn": "2352-3409", "issn-l": null, "volume": "39", "issue": null, "pages": "107459"}, "abstract": "The global issue of preventing the spread of COVID-19 is challenging. One of the most efficient ways to control the pandemic is to have a full coverage of COVID-19 vaccination. Therefore, this paper collected survey data to understand the intention and willingness of COVID-19 vaccination uptake in Qazvin, Iran. With the use of a paper-and-pencil method and multistage stratified cluster sampling, research personnel approached and interviewed a representative sample of adults in Qazvin (n = 10843) between February 19 and April 9, 2021. The survey asked questions regarding sociodemographic information, fear of COVID-19, perceived COVID-19 infectability, perceived behavioral control over COVID-19 vaccination, subjective norm of COVID-19 vaccination, attitude towards COVID-19 vaccination, and intention to get COVID-19 vaccinated. The data collected from this survey were analyzed using descriptive statistics, which were carried out using the IBM SPSS version 17.0.", "doi": "10.1016/j.dib.2021.107459", "pmid": "34660863", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC8500683"}, {"db": "pii", "key": "S2352-3409(21)00741-1"}], "notes": [], "created": "2021-10-21T05:00:29.137Z", "modified": "2023-06-19T15:21:28.910Z"}, {"entity": "publication", "iuid": "5209cda5a4434416b9a275a6087f708e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5209cda5a4434416b9a275a6087f708e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5209cda5a4434416b9a275a6087f708e"}}, "title": "A global observational analysis to understand changes in air quality during exceptionally low anthropogenic emission conditions", "authors": [{"family": "Sokhi", "given": "Ranjeet S", "initials": "RS"}, {"family": "Singh", "given": "Vikas", "initials": "V"}, {"family": "Querol", "given": "Xavier", "initials": "X"}, {"family": "Finardi", "given": "Sandro", "initials": "S"}, {"family": "Targino", "given": "Admir Cr\u00e9so", "initials": "AC"}, {"family": "Andrade", "given": "Maria de Fatima", "initials": "MdF"}, {"family": "Pavlovic", "given": "Radenko", "initials": "R"}, {"family": "Garland", "given": "Rebecca M", "initials": "RM"}, {"family": "Massagu\u00e9", "given": "Jordi", "initials": "J"}, {"family": "Kong", "given": "Shaofei", "initials": "S"}, {"family": "Baklanov", "given": "Alexander", "initials": "A"}, {"family": "Ren", "given": "Lu", "initials": "L"}, {"family": "Tarasova", "given": "Oksana", "initials": "O"}, {"family": "Carmichael", "given": "Greg", "initials": "G"}, {"family": "Peuch", "given": "Vincent Henri", "initials": "VH"}, {"family": "Anand", "given": "Vrinda", "initials": "V"}, {"family": "Arbilla", "given": "Graciela", "initials": "G"}, {"family": "Badali", "given": "Kaitlin", "initials": "K"}, {"family": "Beig", "given": "Gufran", "initials": "G"}, {"family": "Belalcazar", "given": "Luis Carlos", "initials": "LC"}, {"family": "Bolignano", "given": "Andrea", "initials": "A"}, {"family": "Brimblecombe", "given": "Peter", "initials": "P"}, {"family": "Camacho", "given": "Patricia", "initials": "P"}, {"family": "Casallas", "given": "Alejandro", "initials": "A"}, {"family": "Charland", "given": "Jean Pierre", "initials": "JP"}, {"family": "Choi", "given": "Jason", "initials": "J"}, {"family": "Chourdakis", "given": "Eleftherios", "initials": "E"}, {"family": "Coll", "given": "Isabelle", "initials": "I"}, {"family": "Collins", "given": "Marty", "initials": "M"}, {"family": "Cyrys", "given": "Josef", "initials": "J"}, {"family": "da Silva", "given": "Cleyton Martins", "initials": "CM"}, {"family": "Di Giosa", "given": "Alessandro Domenico", "initials": "AD"}, {"family": "Di Leo", "given": "Anna", "initials": "A"}, {"family": "Ferro", "given": "Camilo", "initials": "C"}, {"family": "Gavidia-Calderon", "given": "Mario", "initials": "M"}, {"family": "Gayen", "given": "Amiya", "initials": "A"}, {"family": "Ginzburg", "given": "Alexander", "initials": "A"}, {"family": "Godefroy", "given": "Fabrice", "initials": "F"}, {"family": "Gonzalez", "given": "Yuri Alexandra", "initials": "YA"}, {"family": "Guevara-Luna", "given": "Marco", "initials": "M"}, {"family": "Haque", "given": "Sk Mafizul", "initials": "SM"}, {"family": "Havenga", "given": "Henno", "initials": "H"}, {"family": "Herod", "given": "Dennis", "initials": "D"}, {"family": "H\u00f5rrak", "given": "Urmas", "initials": "U"}, {"family": "Hussein", "given": "Tareq", "initials": "T"}, {"family": "Ibarra", "given": "Sergio", "initials": "S"}, {"family": "Jaimes", "given": "Monica", "initials": "M"}, {"family": "Kaasik", "given": "Marko", "initials": "M"}, {"family": "Khaiwal", "given": "Ravindra", "initials": "R"}, {"family": "Kim", "given": "Jhoon", "initials": "J"}, {"family": "Kousa", "given": "Anu", "initials": "A"}, {"family": "Kukkonen", "given": "Jaakko", "initials": "J"}, {"family": "Kulmala", "given": "Markku", "initials": "M"}, {"family": "Kuula", "given": "Joel", "initials": "J"}, {"family": "La Violette", "given": "Nathalie", "initials": "N"}, {"family": "Lanzani", "given": "Guido", "initials": "G"}, {"family": "Liu", "given": "Xi", "initials": "X"}, {"family": "MacDougall", "given": "Stephanie", "initials": "S"}, {"family": "Manseau", "given": "Patrick M", "initials": "PM"}, {"family": "Marchegiani", "given": "Giada", "initials": "G"}, {"family": "McDonald", "given": "Brian", "initials": "B"}, {"family": "Mishra", "given": "Swasti Vardhan", "initials": "SV"}, {"family": "Molina", "given": "Luisa T", "initials": "LT"}, {"family": "Mooibroek", "given": "Dennis", "initials": "D"}, {"family": "Mor", "given": "Suman", "initials": "S"}, {"family": "Moussiopoulos", "given": "Nicolas", "initials": "N"}, {"family": "Murena", "given": "Fabio", "initials": "F"}, {"family": "Niemi", "given": "Jarkko V", "initials": "JV"}, {"family": "Noe", "given": "Steffen", "initials": "S"}, {"family": "Nogueira", "given": "Thiago", "initials": "T"}, {"family": "Norman", "given": "Michael", "initials": "M"}, {"family": "P\u00e9rez-Cama\u00f1o", "given": "Juan Luis", "initials": "JL"}, {"family": "Pet\u00e4j\u00e4", "given": "Tuukka", "initials": "T"}, {"family": "Piketh", "given": "Stuart", "initials": "S"}, {"family": "Rathod", "given": "Aditi", "initials": "A"}, {"family": "Reid", "given": "Ken", "initials": "K"}, {"family": "Retama", "given": "Armando", "initials": "A"}, {"family": "Rivera", "given": "Olivia", "initials": "O"}, {"family": "Rojas", "given": "N\u00e9stor Y", "initials": "NY"}, {"family": "Rojas-Quincho", "given": "Jhojan P", "initials": "JP"}, {"family": "San Jos\u00e9", "given": "Roberto", "initials": "R"}, {"family": "S\u00e1nchez", "given": "Od\u00f3n", "initials": "O"}, {"family": "Seguel", "given": "Rodrigo J", "initials": "RJ"}, {"family": "Sillanp\u00e4\u00e4", "given": "Salla", "initials": "S"}, {"family": "Su", "given": "Yushan", "initials": "Y"}, {"family": "Tapper", "given": "Nigel", "initials": "N"}, {"family": "Terrazas", "given": "Antonio", "initials": "A"}, {"family": "Timonen", "given": "Hilkka", "initials": "H"}, {"family": "Toscano", "given": "Domenico", "initials": "D"}, {"family": "Tsegas", "given": "George", "initials": "G"}, {"family": "Velders", "given": "Guus J M", "initials": "GJM"}, {"family": "Vlachokostas", "given": "Christos", "initials": "C"}, {"family": "von Schneidemesser", "given": "Erika", "initials": "E"}, {"family": "VPM", "given": "Rajasree", "initials": "R"}, {"family": "Yadav", "given": "Ravi", "initials": "R"}, {"family": "Zalakeviciute", "given": "Rasa", "initials": "R"}, {"family": "Zavala", "given": "Miguel", "initials": "M"}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "Environ Int", "issn": "0160-4120", "volume": "157", "pages": "106818", "issn-l": null}, "abstract": null, "doi": "10.1016/j.envint.2021.106818", "pmid": null, "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-27T09:40:05.202Z", "modified": "2021-08-27T09:40:05.218Z"}, {"entity": "publication", "iuid": "2d92617b4d3e42e2beca4d29d9785cba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d92617b4d3e42e2beca4d29d9785cba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d92617b4d3e42e2beca4d29d9785cba"}}, "title": "A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome: No Evidence of Benefit, Supported by Epidemiology and In Vitro Data", "authors": [{"family": "Wel\u00e9n", "given": "Karin", "initials": "K"}, {"family": "Rosendal", "given": "Ebba", "initials": "E"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Lenman", "given": "Annasara", "initials": "A"}, {"family": "Freyhult", "given": "Eva", "initials": "E"}, {"family": "Fonseca-Rodr\u00edguez", "given": "Osvaldo", "initials": "O"}, {"family": "Bremell", "given": "Daniel", "initials": "D"}, {"family": "Stranne", "given": "Johan", "initials": "J"}, {"family": "Balkhed", "given": "\u00c5se \u00d6stholm", "initials": "\u00c5\u00d6"}, {"family": "Niward", "given": "Katarina", "initials": "K"}, {"family": "Repo", "given": "Johanna", "initials": "J"}, {"family": "Robinsson", "given": "David", "initials": "D"}, {"family": "Henningsson", "given": "Anna J", "initials": "AJ"}, {"family": "Styrke", "given": "Johan", "initials": "J"}, {"family": "Angelin", "given": "Martin", "initials": "M"}, {"family": "Lindquist", "given": "Elisabeth", "initials": "E"}, {"family": "Allard", "given": "Annika", "initials": "A"}, {"family": "Becker", "given": "Miriam", "initials": "M"}, {"family": "Rudolfsson", "given": "Stina", "initials": "S"}, {"family": "Buckland", "given": "Robert", "initials": "R"}, {"family": "Carlsson", "given": "Camilla Thellenberg", "initials": "CT"}, {"family": "Bjartell", "given": "Anders", "initials": "A"}, {"family": "Nilsson", "given": "Anna C", "initials": "AC"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Connolly", "given": "Anne Marie Fors", "initials": "AMF"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "Josefsson", "given": "Andreas", "initials": "A"}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "European Urology", "issn": "0302-2838", "issn-l": null}, "abstract": null, "doi": "10.1016/j.eururo.2021.12.013", "pmid": "34980495", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T14:42:26.854Z", "modified": "2022-01-10T15:43:27.765Z"}, {"entity": "publication", "iuid": "d14b85b93cb844bcbed101295548421f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d14b85b93cb844bcbed101295548421f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d14b85b93cb844bcbed101295548421f"}}, "title": "Unsuccessful and Successful Clinical Trials in Acute Respiratory Distress Syndrome: Addressing Physiology-Based Gaps.", "authors": [{"family": "Villar", "given": "Jes\u00fas", "initials": "J"}, {"family": "Ferrando", "given": "Carlos", "initials": "C"}, {"family": "Tusman", "given": "Gerardo", "initials": "G"}, {"family": "Berra", "given": "Lorenzo", "initials": "L"}, {"family": "Rodr\u00edguez-Su\u00e1rez", "given": "Pedro", "initials": "P"}, {"family": "Su\u00e1rez-Sipmann", "given": "Fernando", "initials": "F"}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "Front Physiol", "issn": "1664-042X", "volume": "12", "pages": "774025", "issn-l": null}, "abstract": "The acute respiratory distress syndrome (ARDS) is a severe form of acute hypoxemic respiratory failure caused by an insult to the alveolar-capillary membrane, resulting in a marked reduction of aerated alveoli, increased vascular permeability and subsequent interstitial and alveolar pulmonary edema, reduced lung compliance, increase of physiological dead space, and hypoxemia. Most ARDS patients improve their systemic oxygenation, as assessed by the ratio between arterial partial pressure of oxygen and inspired oxygen fraction, with conventional intensive care and the application of moderate-to-high levels of positive end-expiratory pressure. However, in some patients hypoxemia persisted because the lungs are markedly injured, remaining unresponsive to increasing the inspiratory fraction of oxygen and positive end-expiratory pressure. For decades, mechanical ventilation was the only standard support technique to provide acceptable oxygenation and carbon dioxide removal. Mechanical ventilation provides time for the specific therapy to reverse the disease-causing lung injury and for the recovery of the respiratory function. The adverse effects of mechanical ventilation are direct consequences of the changes in pulmonary airway pressures and intrathoracic volume changes induced by the repetitive mechanical cycles in a diseased lung. In this article, we review 14 major successful and unsuccessful randomized controlled trials conducted in patients with ARDS on a series of techniques to improve oxygenation and ventilation published since 2010. Those trials tested the effects of adjunctive therapies (neuromuscular blocking agents, prone positioning), methods for selecting the optimum positive end-expiratory pressure (after recruitment maneuvers, or guided by esophageal pressure), high-frequency oscillatory ventilation, extracorporeal oxygenation, and pharmacologic immune modulators of the pulmonary and systemic inflammatory responses in patients affected by ARDS. We will briefly comment physiology-based gaps of negative trials and highlight the possible needs to address in future clinical trials in ARDS.", "doi": "10.3389/fphys.2021.774025", "pmid": "34916959", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8669801"}], "notes": [], "created": "2021-12-18T17:42:17.076Z", "modified": "2021-12-18T17:42:17.088Z"}, {"entity": "publication", "iuid": "acb0b2a3a77b41a6b28110c03160a6b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/acb0b2a3a77b41a6b28110c03160a6b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/acb0b2a3a77b41a6b28110c03160a6b4"}}, "title": "The effects of different travel modes and travel destinations on COVID-19 transmission in global cities.", "authors": [{"family": "Zhu", "given": "Rui", "initials": "R"}, {"family": "Anselin", "given": "Luc", "initials": "L"}, {"family": "Batty", "given": "Michael", "initials": "M"}, {"family": "Kwan", "given": "Mei-Po", "initials": "MP"}, {"family": "Chen", "given": "Min", "initials": "M"}, {"family": "Luo", "given": "Wei", "initials": "W"}, {"family": "Cheng", "given": "Tao", "initials": "T"}, {"family": "Lim", "given": "Che Kang", "initials": "CK"}, {"family": "Santi", "given": "Paolo", "initials": "P"}, {"family": "Cheng", "given": "Cheng", "initials": "C"}, {"family": "Gu", "given": "Qiushi", "initials": "Q"}, {"family": "Wong", "given": "Man Sing", "initials": "MS"}, {"family": "Zhang", "given": "Kai", "initials": "K"}, {"family": "L\u00fc", "given": "Guonian", "initials": "G"}, {"family": "Ratti", "given": "Carlo", "initials": "C"}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "Sci Bull (Beijing)", "issn": "2095-9273", "issn-l": null}, "abstract": null, "doi": "10.1016/j.scib.2021.11.023", "pmid": "34868708", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2095-9273(21)00731-3"}, {"db": "pmc", "key": "PMC8631046"}], "notes": [], "created": "2021-12-12T07:08:23.462Z", "modified": "2021-12-12T07:09:00.122Z"}, {"entity": "publication", "iuid": "df7653ff47fd45239730fb0c6777cc43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/df7653ff47fd45239730fb0c6777cc43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/df7653ff47fd45239730fb0c6777cc43"}}, "title": "Epidemiology and factors associated with COVID-19 outbreak-related deaths in patients admitted to medical centers of Mazandaran University of Medical Sciences.", "authors": [{"family": "Khankeh", "given": "Hamidreza", "initials": "H"}, {"family": "Farrokhi", "given": "Mehrdad", "initials": "M"}, {"family": "Ghadicolaei", "given": "Hassan Talebi", "initials": "HT"}, {"family": "Mazhin", "given": "Sadegh Ahmadi", "initials": "SA"}, {"family": "Roudini", "given": "Juliet", "initials": "J"}, {"family": "Mohsenzadeh", "given": "Yazdan", "initials": "Y"}, {"family": "Hadinejad", "given": "Zoya", "initials": "Z"}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "J Educ Health Promot", "issn": "2277-9531", "volume": "10", "pages": "426", "issn-l": null}, "abstract": "The first case of COVID-19 was reported in Iran on February 19, 2020, in Qom. Since Mazandaran is one of the high-risk provinces with many patients and deaths, this study was conducted to investigate the epidemiological characteristics of COVID-19-related deaths in Mazandaran.\n\nIn this descriptive study, demographic information and clinical findings in patients who died following COVID-19 in the medical centers of Mazandaran University of Medical Sciences from February 8, 2020, to October 10, 2020, were extracted. Data were analyzed by using SPSS 21. Logistic regression was used to compare the data. P < 0.05 was considered as the significance level.\n\nOut of a total of 34,039 patients admitted during the 8 months, 2907 patients died. Of these, 1529 (52%) were male, and the rest were female. In terms of age, 10 cases in the age group of fewer than 15 years, 229 cases in the age group of 15-44 years, 864 patients in the age group of 45-64 years, and 1793 people in the age group of 65 years and over died. 2206 people (more than 75%) by personal visit referred to medical centers. The mortality rate was more than 8 cases per 100 hospitalized patients. Men were 16% more likely to die from COVID-19 than women.\n\nOlder adults over 65 have the highest incidence and death rate due to this disease. The incidence rate was higher in women, and the death rate was higher in men, which differs from the national pattern.", "doi": "10.4103/jehp.jehp_192_21", "pmid": "35071632", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "JEHP-10-426"}, {"db": "pmc", "key": "PMC8719545"}], "notes": [], "created": "2022-01-26T10:16:48.419Z", "modified": "2022-01-26T10:16:48.452Z"}, {"entity": "publication", "iuid": "d4d0b48d3aee47a6b6f277156b63cfc3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4d0b48d3aee47a6b6f277156b63cfc3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4d0b48d3aee47a6b6f277156b63cfc3"}}, "title": "Effects of immunosuppressive drugs on COVID-19 severity in patients with autoimmune hepatitis.", "authors": [{"family": "Efe", "given": "Cumali", "initials": "C", "orcid": "0000-0001-6593-5702", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cd621ab96e04e678b0188c48d54b90a.json"}}, {"family": "Lammert", "given": "Craig", "initials": "C", "orcid": "0000-0003-3809-640X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3c2fe9871074a22a95a55375edc3b62.json"}}, {"family": "Ta\u015f\u00e7\u0131lar", "given": "Koray", "initials": "K"}, {"family": "Dhanasekaran", "given": "Renumathy", "initials": "R", "orcid": "0000-0001-8819-7511", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/144c4ddb38ed4c99adca4b6ae626a533.json"}}, {"family": "Ebik", "given": "Berat", "initials": "B"}, {"family": "Higuera-de la Tijera", "given": "Fatima", "initials": "F"}, {"family": "Cal\u0131\u015fkan", "given": "Ali R", "initials": "AR"}, {"family": "Peralta", "given": "Mirta", "initials": "M"}, {"family": "Gerussi", "given": "Alessio", "initials": "A"}, {"family": "Massoumi", "given": "Hatef", "initials": "H"}, {"family": "Catana", "given": "Andreea M", "initials": "AM"}, {"family": "Purnak", "given": "Tugrul", "initials": "T"}, {"family": "Rigamonti", "given": "Cristina", "initials": "C"}, {"family": "Aldana", "given": "Andres J G", "initials": "AJG"}, {"family": "Khakoo", "given": "Nidah", "initials": "N"}, {"family": "Nazal", "given": "Leyla", "initials": "L"}, {"family": "Frager", "given": "Shalom", "initials": "S"}, {"family": "Demir", "given": "Nurhan", "initials": "N"}, {"family": "Irak", "given": "Kader", "initials": "K"}, {"family": "Meleko\u011flu-Ellik", "given": "Zeynep", "initials": "Z"}, {"family": "Kacmaz", "given": "H\u00fcseyin", "initials": "H"}, {"family": "Balaban", "given": "Yasemin", "initials": "Y"}, {"family": "Atay", "given": "Kadri", "initials": "K"}, {"family": "Eren", "given": "Fatih", "initials": "F"}, {"family": "Alvares-da-Silva", "given": "Mario R", "initials": "MR"}, {"family": "Cristoferi", "given": "Laura", "initials": "L"}, {"family": "Urzua", "given": "\u00c1lvaro", "initials": "\u00c1"}, {"family": "E\u015fkazan", "given": "Tu\u011f\u00e7e", "initials": "T"}, {"family": "Magro", "given": "Bianca", "initials": "B"}, {"family": "Snijders", "given": "Romee", "initials": "R"}, {"family": "Barut\u00e7u", "given": "Sezgin", "initials": "S"}, {"family": "Lytvyak", "given": "Ellina", "initials": "E"}, {"family": "Zazueta", "given": "Godolfino M", "initials": "GM"}, {"family": "Demirezer-Bolat", "given": "Aylin", "initials": "A"}, {"family": "Ayd\u0131n", "given": "Mesut", "initials": "M"}, {"family": "Heurgue-Berlot", "given": "Alexandra", "initials": "A"}, {"family": "De Martin", "given": "Eleonora", "initials": "E"}, {"family": "Ekin", "given": "Naz\u0131m", "initials": "N"}, {"family": "Y\u0131ld\u0131r\u0131m", "given": "S\u00fcmeyra", "initials": "S"}, {"family": "Yavuz", "given": "Ahmet", "initials": "A"}, {"family": "B\u0131y\u0131k", "given": "Murat", "initials": "M"}, {"family": "Narro", "given": "Graciela C", "initials": "GC"}, {"family": "K\u0131y\u0131c\u0131", "given": "Murat", "initials": "M"}, {"family": "Aky\u0131ld\u0131z", "given": "Murat", "initials": "M"}, {"family": "Kahramano\u011flu-Aksoy", "given": "Evrim", "initials": "E"}, {"family": "Vincent", "given": "Maria", "initials": "M"}, {"family": "Carr", "given": "Rotonya M", "initials": "RM"}, {"family": "G\u00fcn\u015far", "given": "Fulya", "initials": "F"}, {"family": "Reyes", "given": "Eira C", "initials": "EC"}, {"family": "Harputluo\u011flu", "given": "Murat", "initials": "M"}, {"family": "Aloman", "given": "Costica", "initials": "C"}, {"family": "Gatselis", "given": "Nikolaos K", "initials": "NK"}, {"family": "\u00dcst\u00fcnda\u011f", "given": "Y\u00fccel", "initials": "Y"}, {"family": "Brahm", "given": "Javier", "initials": "J"}, {"family": "Vargas", "given": "Nataly C E", "initials": "NCE"}, {"family": "G\u00fczelbulut", "given": "Fatih", "initials": "F", "orcid": "0000-0003-4889-208X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b376f922688245a6a37c9d9db086c5c0.json"}}, {"family": "Garcia", "given": "Sandro R", "initials": "SR"}, {"family": "Aguirre", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-6291-2545", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e597179292724adeafa651fb99c26573.json"}}, {"family": "Anders", "given": "Margarita", "initials": "M"}, {"family": "Ratusnu", "given": "Natalia", "initials": "N"}, {"family": "Hatemi", "given": "Ibrahim", "initials": "I"}, {"family": "Mendizabal", "given": "Manuel", "initials": "M"}, {"family": "Floreani", "given": "Annarosa", "initials": "A"}, {"family": "Fagiuoli", "given": "Stefano", "initials": "S"}, {"family": "Silva", "given": "Marcelo", "initials": "M"}, {"family": "Idilman", "given": "Ramazan", "initials": "R"}, {"family": "Satapathy", "given": "Sanjaya K", "initials": "SK", "orcid": "0000-0003-0153-2829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46079042944846e2a2ab5791ffd3ac85.json"}}, {"family": "Silveira", "given": "Marina", "initials": "M"}, {"family": "Drenth", "given": "Joost P H", "initials": "JPH", "orcid": "0000-0001-8027-3073", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7b6dc5554ee4911b90e100f311d69ca.json"}}, {"family": "Dalekos", "given": "George N", "initials": "GN"}, {"family": "N Assis", "given": "David", "initials": "D"}, {"family": "Bj\u00f6rnsson", "given": "Einar", "initials": "E", "orcid": "0000-0002-8392-0632", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d61afcd69274877ab6be778e0b191f6.json"}}, {"family": "Boyer", "given": "James L", "initials": "JL"}, {"family": "Yoshida", "given": "Eric M", "initials": "EM"}, {"family": "Invernizzi", "given": "Pietro", "initials": "P", "orcid": "0000-0003-3262-1998", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2e4ae30eec648eea09a264143952d7e.json"}}, {"family": "Levy", "given": "Cynthia", "initials": "C", "orcid": "0000-0001-5498-6037", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15588be194364b57b71d2f15526456c7.json"}}, {"family": "Montano-Loza", "given": "Aldo J", "initials": "AJ", "orcid": "0000-0002-2511-7980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a64b4bf7fe0848c6bde4f61b031d8900.json"}}, {"family": "Schiano", "given": "Thomas D", "initials": "TD"}, {"family": "Ridruejo", "given": "Ezequiel", "initials": "E"}, {"family": "Wahlin", "given": "Staffan", "initials": "S"}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "Liver Int", "issn": "1478-3231", "issn-l": null}, "abstract": "We investigated associations between baseline use of immunosuppressive drugs and severity of Coronavirus Disease 2019 (COVID-19) in autoimmune hepatitis (AIH).\n\nData of AIH patients with laboratory confirmed COVID-19 were retrospectively collected from 15 countries. The outcomes of AIH patients who were on immunosuppression at the time of COVID-19 were compared to patients who were not on AIH medication. The clinical courses of COVID-19 were classified as (i)-no hospitalization, (ii)-hospitalization without oxygen supplementation, (iii)-hospitalization with oxygen supplementation by nasal cannula or mask, (iv)-intensive care unit (ICU) admission with non-invasive mechanical ventilation, (v)-ICU admission with invasive mechanical ventilation or (vi)-death and analysed using ordinal logistic regression.\n\nWe included 254 AIH patients (79.5%, female) with a median age of 50 (range, 17-85) years. At the onset of COVID-19, 234 patients (92.1%) were on treatment with glucocorticoids (n = 156), thiopurines (n = 151), mycophenolate mofetil (n = 22) or tacrolimus (n = 16), alone or in combinations. Overall, 94 (37%) patients were hospitalized and 18 (7.1%) patients died. Use of systemic glucocorticoids (adjusted odds ratio [aOR] 4.73, 95% CI 1.12-25.89) and thiopurines (aOR 4.78, 95% CI 1.33-23.50) for AIH was associated with worse COVID-19 severity, after adjusting for age-sex, comorbidities and presence of cirrhosis. Baseline treatment with mycophenolate mofetil (aOR 3.56, 95% CI 0.76-20.56) and tacrolimus (aOR 4.09, 95% CI 0.69-27.00) were also associated with more severe COVID-19 courses in a smaller subset of treated patients.\n\nBaseline treatment with systemic glucocorticoids or thiopurines prior to the onset of COVID-19 was significantly associated with COVID-19 severity in patients with AIH.", "doi": "10.1111/liv.15121", "pmid": "34846800", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T18:10:28.983Z", "modified": "2021-12-18T18:10:29.323Z"}, {"entity": "publication", "iuid": "1ff9c3f0e55f4ec5bac4e50071aa7305", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ff9c3f0e55f4ec5bac4e50071aa7305.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ff9c3f0e55f4ec5bac4e50071aa7305"}}, "title": "Cohort study of the characteristics and outcomes in patients with COVID-19 and in-hospital cardiac arrest.", "authors": [{"family": "Holm", "given": "Astrid", "initials": "A", "orcid": "0000-0003-4226-7494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7dede94c48304ae09e2db9691584ab36.json"}}, {"family": "Jerkeman", "given": "Matilda", "initials": "M"}, {"family": "Sultanian", "given": "Pedram", "initials": "P", "orcid": "0000-0002-6941-6659", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/903a11645aaa4218bd36f1e51187783c.json"}}, {"family": "Lundgren", "given": "Peter", "initials": "P"}, {"family": "Ravn-Fischer", "given": "Annica", "initials": "A"}, {"family": "Israelsson", "given": "Johan", "initials": "J"}, {"family": "Giesecke", "given": "Jasna", "initials": "J"}, {"family": "Herlitz", "given": "Johan", "initials": "J"}, {"family": "Rawshani", "given": "Araz", "initials": "A", "orcid": "0000-0003-2066-3533", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ffcc83bb40a4a22aec7dffe6c890da0.json"}}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "11", "pages": "e054943", "issn-l": "2044-6055"}, "abstract": "We studied characteristics, survival, causes of cardiac arrest, conditions preceding cardiac arrest, predictors of survival and trends in the prevalence of COVID-19 among in-hospital cardiac arrest (IHCA) cases.\n\nRegistry-based observational study.\n\nWe studied all cases (\u226518 years of age) of IHCA receiving cardiopulmonary resuscitation in the Swedish Registry for Cardiopulmonary Resuscitation during 15 March 2020 to 31 December 2020. A total of 1613 patients were included and divided into the following groups: ongoing infection (COVID-19+; n=182), no infection (COVID-19-; n=1062) and unknown/not assessed (n=369).\n\nWe studied monthly trends in proportions of COVID-19 associated IHCAs, causes of IHCA in relation to COVID-19 status, clinical conditions preceding the cardiac arrest and predictors of survival.\n\nThe rate of COVID-19+ patients suffering an IHCA increased to 23% during the first pandemic wave (April), then abated to 3% in July, and then increased to 19% during the second wave (December). Among COVID-19+ cases, 43% had respiratory insufficiency or infection as the underlying cause of the cardiac arrest, compared with 18% among COVID-19- cases. The most common clinical sign preceding cardiac arrest was hypoxia (57%) among COVID-19+ cases. OR for 30-day survival for COVID-19+ cases was 0.50 (95% CI 0.33 to 0.76), compared with COVID-19- cases.\n\nDuring pandemic peaks, up to one-fourth of all IHCAs are complicated by COVID-19, and these patients have halved chance of survival, with women displaying the worst outcomes.", "doi": "10.1136/bmjopen-2021-054943", "pmid": "34848525", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-054943"}, {"db": "pmc", "key": "PMC8635887"}], "notes": [], "created": "2021-12-18T18:09:55.672Z", "modified": "2021-12-18T18:09:55.806Z"}, {"entity": "publication", "iuid": "3e5fbd3eafad422c9ff64235ae8e42eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3e5fbd3eafad422c9ff64235ae8e42eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3e5fbd3eafad422c9ff64235ae8e42eb"}}, "title": "Avoiding bias in self-controlled case series studies of coronavirus disease 2019.", "authors": [{"family": "Fonseca-Rodr\u00edguez", "given": "Osvaldo", "initials": "O"}, {"family": "Fors Connolly", "given": "Anne-Marie", "initials": "AM", "orcid": "0000-0001-9215-4047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff46cc7d9e374929a14350748727ba60.json"}}, {"family": "Katsoularis", "given": "Ioannis", "initials": "I"}, {"family": "Lindmark", "given": "Krister", "initials": "K"}, {"family": "Farrington", "given": "Paddy", "initials": "P", "orcid": "0000-0002-7148-2612", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/586b1e765406444d85c192ba61708ce0.json"}}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "Stat Med", "issn": "1097-0258", "issn-l": null, "volume": "40", "issue": "27", "pages": "6197-6208"}, "abstract": "Many studies, including self-controlled case series (SCCS) studies, are being undertaken to quantify the risks of complications following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). One such SCCS study, based on all COVID-19 cases arising in Sweden over an 8-month period, has shown that SARS-CoV-2 infection increases the risks of AMI and ischemic stroke. Some features of SARS-CoV-2 infection and COVID-19, present in this study and likely in others, complicate the analysis and may introduce bias. In the present paper we describe these features, and explore the biases they may generate. Motivated by data-based simulations, we propose methods to reduce or remove these biases.", "doi": "10.1002/sim.9179", "pmid": "34470078", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8661887"}], "notes": [], "created": "2021-09-06T06:17:45.140Z", "modified": "2023-06-19T14:47:13.405Z"}, {"entity": "publication", "iuid": "bd9c86c4cf594ec6a0e7a3155401ba54", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bd9c86c4cf594ec6a0e7a3155401ba54.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bd9c86c4cf594ec6a0e7a3155401ba54"}}, "title": "Application of Stem Cell-Derived Extracellular Vesicles as an Innovative Theranostics in Microbial Diseases.", "authors": [{"family": "Keshavarz Alikhani", "given": "Hani", "initials": "H"}, {"family": "Shokoohian", "given": "Bahare", "initials": "B"}, {"family": "Rezasoltani", "given": "Sama", "initials": "S"}, {"family": "Hossein-Khannazer", "given": "Nikoo", "initials": "N"}, {"family": "Yadegar", "given": "Abbas", "initials": "A"}, {"family": "Hassan", "given": "Moustapha", "initials": "M"}, {"family": "Vosough", "given": "Massoud", "initials": "M"}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "Front Microbiol", "issn": "1664-302X", "volume": "12", "pages": "785856", "issn-l": null}, "abstract": "Extracellular vesicles (EVs), as nano-/micro-scale vehicles, are membranous particles containing various cargoes including peptides, proteins, different types of RNAs and other nucleic acids, and lipids. These vesicles are produced by all cell types, in which stem cells are a potent source for them. Stem cell-derived EVs could be promising platforms for treatment of infectious diseases and early diagnosis. Infectious diseases are responsible for more than 11 million deaths annually. Highly transmissible nature of some microbes, such as newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), drives researcher's interest to set up different strategies to develop novel therapeutic strategies. Recently, EVs-based diagnostic and therapeutic approaches have been launched and gaining momentum very fast. The efficiency of stem cell-derived EVs on treatment of clinical complications of different viruses and bacteria, such as SARS-CoV-2, hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), Staphylococcus aureus, Escherichia coli has been demonstrated. On the other hand, microbial pathogens are able to incorporate their components into their EVs. The microbe-derived EVs have different physiological and pathological impacts on the other organisms. In this review, we briefly discussed biogenesis and the fate of EVs. Then, EV-based therapy was described and recent developments in understanding the potential application of stem cell-derived EVs on pathogenic microorganisms were recapitulated. Furthermore, the mechanisms by which EVs were exploited to fight against infectious diseases were highlighted. Finally, the deriver challenges in translation of stem cell-derived EVs into the clinical arena were explored.", "doi": "10.3389/fmicb.2021.785856", "pmid": "34917064", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8669997"}], "notes": [], "created": "2021-12-18T17:41:45.760Z", "modified": "2021-12-18T17:42:00.602Z"}, {"entity": "publication", "iuid": "61cb9195191e453f9f426b4888551047", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61cb9195191e453f9f426b4888551047.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61cb9195191e453f9f426b4888551047"}}, "title": "Using Ecological Momentary Assessment to Study the Development of COVID-19 Worries in Sweden: Longitudinal Study.", "authors": [{"family": "Schulz", "given": "Peter Johannes", "initials": "PJ", "orcid": "0000-0003-4281-489X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e186ea7760d84db695253b781d054226.json"}}, {"family": "Andersson", "given": "Elin M", "initials": "EM", "orcid": "0000-0002-9847-4196", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/febdb7c142b048deb0b5ffd9f998f289.json"}}, {"family": "Bizzotto", "given": "Nicole", "initials": "N", "orcid": "0000-0002-4730-1367", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ccad820d0f746ef92ca47b5e24a17fb.json"}}, {"family": "Norberg", "given": "Margareta", "initials": "M", "orcid": "0000-0003-2475-7131", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d9734ccbd5e46c5be2b3922d9af4b81.json"}}], "type": "journal article", "published": "2021-11-29", "journal": {"title": "J Med Internet Res", "issn": "1438-8871", "volume": "23", "issue": "11", "pages": "e26743", "issn-l": null}, "abstract": "The foray of COVID-19 around the globe has certainly instigated worries in many people, and lockdown measures may well have triggered more specific worries. Sweden, more than other countries, relied on voluntary measures to fight the pandemic. This provides a particularly interesting context to assess people's reactions to the threat of the pandemic.\n\nThe general aim of this study was to better understand the worried reactions to the virus and the associated lockdown measures. As there have been very few longitudinal studies in this area published to date, development of feelings of worry over time was analyzed over a longer range than in previous research. Affective variables, worry in particular, were included because most of the research in this field has focused on cognitive variables. To employ new methodology, ecological momentary assessment was used for data collection and a multilevel modeling approach was adopted for data analysis.\n\nResults were based on an unbalanced panel sample of 260 Swedish participants filling in 3226 interview questionnaires by smartphone over a 7-week period in 2020 during the rapid rise of cases in the early phase of the pandemic. Causal factors considered in this study included the perceived severity of an infection, susceptibility of a person to the threat posed by the virus, perceived efficacy of safeguarding measures, and assessment of government action against the spread of COVID-19. The effect of these factors on worries was traced in two analytical steps: the effects at the beginning of the study and the effect on the trend during the study.\n\nThe level of general worry related to COVID-19 was modest (mean 6.67, SD 2.54 on an 11-point Likert scale); the increase during the study period was small, but the interindividual variation of both the worry level and its increase over time was large. Findings confirmed that the hypothesized causal factors (severity of infection, susceptibility to the threat of the virus, efficacy of safeguarding, and assessment of government preventive action) did indeed affect the level of worry.\n\nThe results confirmed earlier research in a very special case and demonstrated the usefulness of a different study design, which takes a longitudinal perspective, and a new type of data analysis borrowed from multilevel study design.", "doi": "10.2196/26743", "pmid": "34847065", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "v23i11e26743"}], "notes": [], "created": "2021-12-18T18:10:14.526Z", "modified": "2021-12-18T18:10:14.690Z"}, {"entity": "publication", "iuid": "383c0fe192104c33b63bb8e5ec51a54a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/383c0fe192104c33b63bb8e5ec51a54a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/383c0fe192104c33b63bb8e5ec51a54a"}}, "title": "The Glomerular Endothelium Restricts Albumin Filtration.", "authors": [{"family": "Ballermann", "given": "Barbara J", "initials": "BJ"}, {"family": "Nystr\u00f6m", "given": "Jenny", "initials": "J"}, {"family": "Haraldsson", "given": "B\u00f6rje", "initials": "B"}], "type": "journal article", "published": "2021-11-29", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "8", "pages": "766689", "issn-l": null}, "abstract": "Inflammatory activation and/or dysfunction of the glomerular endothelium triggers proteinuria in many systemic and localized vascular disorders. Among them are the thrombotic microangiopathies, many forms of glomerulonephritis, and acute inflammatory episodes like sepsis and COVID-19 illness. Another example is the chronic endothelial dysfunction that develops in cardiovascular disease and in metabolic disorders like diabetes. While the glomerular endothelium is a porous sieve that filters prodigious amounts of water and small solutes, it also bars the bulk of albumin and large plasma proteins from passing into the glomerular filtrate. This endothelial barrier function is ascribed predominantly to the endothelial glycocalyx with its endothelial surface layer, that together form a relatively thick, mucinous coat composed of glycosaminoglycans, proteoglycans, glycolipids, sialomucins and other glycoproteins, as well as secreted and circulating proteins. The glycocalyx/endothelial surface layer not only covers the glomerular endothelium; it extends into the endothelial fenestrae. Some glycocalyx components span or are attached to the apical endothelial cell plasma membrane and form the formal glycocalyx. Other components, including small proteoglycans and circulating proteins like albumin and orosomucoid, form the endothelial surface layer and are bound to the glycocalyx due to weak intermolecular interactions. Indeed, bound plasma albumin is a major constituent of the endothelial surface layer and contributes to its barrier function. A role for glomerular endothelial cells in the barrier of the glomerular capillary wall to protein filtration has been demonstrated by many elegant studies. However, it can only be fully understood in the context of other components, including the glomerular basement membrane, the podocytes and reabsorption of proteins by tubule epithelial cells. Discovery of the precise mechanisms that lead to glycocalyx/endothelial surface layer disruption within glomerular capillaries will hopefully lead to pharmacological interventions that specifically target this important structure.", "doi": "10.3389/fmed.2021.766689", "pmid": "34912827", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8667033"}], "notes": [], "created": "2021-12-18T17:48:23.056Z", "modified": "2022-01-04T15:36:39.995Z"}, {"entity": "publication", "iuid": "c3ab6905010440e1a70238b3d4ff0777", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3ab6905010440e1a70238b3d4ff0777.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3ab6905010440e1a70238b3d4ff0777"}}, "title": "Safety and efficacy of the mRNA BNT162b2 vaccine against SARS-CoV-2 in five groups of immunocompromised patients and healthy controls in a prospective open-label clinical trial.", "authors": [{"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Mielke", "given": "Stephan", "initials": "S"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "S\u00f6derdahl", "given": "Gunnar", "initials": "G"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Vesterbacka", "given": "Jan", "initials": "J"}, {"family": "Lindgren", "given": "Gustaf", "initials": "G"}, {"family": "Blixt", "given": "Lisa", "initials": "L"}, {"family": "Friman", "given": "Gustav", "initials": "G"}, {"family": "Wahren-Borgstr\u00f6m", "given": "Emilie", "initials": "E"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Gomez", "given": "Angelica Cuapio", "initials": "AC"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Valentini", "given": "Davide", "initials": "D"}, {"family": "Norlin", "given": "Anna-Carin", "initials": "A"}, {"family": "Thalme", "given": "Anders", "initials": "A"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "Chen", "given": "Margaret S\u00e4llberg", "initials": "MS"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "COVAXID-collaborator group (shown separately)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-29", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": "74", "issue": null, "pages": "103705"}, "abstract": "Patients with immunocompromised disorders have mainly been excluded from clinical trials of vaccination against COVID-19. Thus, the aim of this prospective clinical trial was to investigate safety and efficacy of BNT162b2 mRNA vaccination in five selected groups of immunocompromised patients and healthy controls.\r\n\r\n539 study subjects (449 patients and 90 controls) were included. The patients had either primary (n=90), or secondary immunodeficiency disorders due to human immunodeficiency virus infection (n=90), allogeneic hematopoietic stem cell transplantation/CAR T cell therapy (n=90), solid organ transplantation (SOT) (n=89), or chronic lymphocytic leukemia (CLL) (n=90). The primary endpoint was seroconversion rate two weeks after the second dose. The secondary endpoints were safety and documented SARS-CoV-2 infection.\r\n\r\nAdverse events were generally mild, but one case of fatal suspected unexpected serious adverse reaction occurred. 72.2% of the immunocompromised patients seroconverted compared to 100% of the controls (p=0.004). Lowest seroconversion rates were found in the SOT (43.4%) and CLL (63.3%) patient groups with observed negative impact of treatment with mycophenolate mofetil and ibrutinib, respectively.\r\n\r\nThe results showed that the mRNA BNT162b2 vaccine was safe in immunocompromised patients. Rate of seroconversion was substantially lower than in healthy controls, with a wide range of rates and antibody titres among predefined patient groups and subgroups. This clinical trial highlights the need for additional vaccine doses in certain immunocompromised patient groups to improve immunity.\r\n\r\nKnut and Alice Wallenberg Foundation, the Swedish Research Council, Nordstjernan AB, Region Stockholm, Karolinska Institutet, and organizations for PID/CLL-patients in Sweden.", "doi": "10.1016/j.ebiom.2021.103705", "pmid": "34861491", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Research Area: Vaccine": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S2352-3964(21)00499-0"}, {"db": "pmc", "key": "PMC8629680"}], "notes": [], "created": "2021-12-13T06:18:22.479Z", "modified": "2022-02-08T19:23:35.378Z"}, {"entity": "publication", "iuid": "9772ddb501a945128727b5f4d0cad4da", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9772ddb501a945128727b5f4d0cad4da.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9772ddb501a945128727b5f4d0cad4da"}}, "title": "Evaluation of an Access-Risk-Knowledge (ARK) Platform for Governance of Risk and Change in Complex Socio-Technical Systems", "authors": [{"family": "McDonald", "given": "Nick", "initials": "N"}, {"family": "McKenna", "given": "Lucy", "initials": "L", "orcid": "0000-0002-6035-7656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b86ff32ca1bf48159697fb2fe2f9551b.json"}}, {"family": "Vining", "given": "Rebecca", "initials": "R", "orcid": "0000-0002-2715-8129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6439c14ee8414e53af9294862d552196.json"}}, {"family": "Doyle", "given": "Brian", "initials": "B", "orcid": "0000-0002-9106-9526", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5dadad0ba26f4f6080691dee6f5a74dd.json"}}, {"family": "Liang", "given": "Junli", "initials": "J"}, {"family": "Ward", "given": "Marie E", "initials": "ME", "orcid": "0000-0002-6638-8461", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c905fcea73cc450cbe0e74287b0eb109.json"}}, {"family": "Ulfvengren", "given": "Pernilla", "initials": "P", "orcid": "0000-0002-9709-540X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc00902f545941139d3a4cce8187eae1.json"}}, {"family": "Geary", "given": "Una", "initials": "U"}, {"family": "Guilfoyle", "given": "John", "initials": "J"}, {"family": "Shuhaiber", "given": "Arwa", "initials": "A"}, {"family": "Hernandez", "given": "Julio", "initials": "J", "orcid": "0000-0003-1347-9631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0184091779e41ecbc5d33105d23034c.json"}}, {"family": "Fogarty", "given": "Mary", "initials": "M"}, {"family": "Healy", "given": "Una", "initials": "U"}, {"family": "Tallon", "given": "Christopher", "initials": "C"}, {"family": "Brennan", "given": "Rob", "initials": "R", "orcid": "0000-0001-8236-362X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94edffbb874e4802bba1ef5efb442c4b.json"}}], "type": "journal-article", "published": "2021-11-29", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "23", "pages": "12572", "issn-l": null}, "abstract": null, "doi": "10.3390/ijerph182312572", "pmid": null, "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:56:14.716Z", "modified": "2021-12-12T06:56:14.981Z"}, {"entity": "publication", "iuid": "e7a3924e7b744217b6a3a136c7aadeec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e7a3924e7b744217b6a3a136c7aadeec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e7a3924e7b744217b6a3a136c7aadeec"}}, "title": "Coronavirus disease 2019 in patients with Behcet's disease: a report of 59 cases in Iran.", "authors": [{"family": "Shahram", "given": "Farhad", "initials": "F", "orcid": "0000-0003-1830-6203", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54cc2725d5914d2eb2b8de5bce99c147.json"}}, {"family": "Esalatmanesh", "given": "Kamal", "initials": "K", "orcid": "0000-0001-9675-5237", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b00277eb98524eadbd9d4524e3958a38.json"}}, {"family": "Khabbazi", "given": "Alireza", "initials": "A", "orcid": "0000-0002-9482-6967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c640608a4c7450e9684bcb7b81b6d90.json"}}, {"family": "Rezaieyazdi", "given": "Zahra", "initials": "Z", "orcid": "0000-0001-8731-7999", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cedb94d93a434d37825e67d516b9cd33.json"}}, {"family": "Mirfeizi", "given": "Zahra", "initials": "Z"}, {"family": "Sadeghi", "given": "Alireza", "initials": "A", "orcid": "0000-0002-7406-4790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5682d53ed18245b6a00334b4aaa8c710.json"}}, {"family": "Soroosh", "given": "Mohsen", "initials": "M"}, {"family": "Kavosi", "given": "Hoda", "initials": "H", "orcid": "0000-0003-4762-6943", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b435e9ba4d1c4a999585594ab71664f9.json"}}, {"family": "Alikhani", "given": "Majid", "initials": "M"}, {"family": "Mostafaei", "given": "Shayan", "initials": "S", "orcid": "0000-0002-1966-1306", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24bfddb5f547448e88fa79f34c78ee23.json"}}], "type": "journal article", "published": "2021-11-29", "journal": {"title": "Clin Rheumatol", "issn": "1434-9949", "issn-l": null}, "abstract": "To present the clinical characteristics, disease course, management, and outcomes of COVID-19 infection in patients with Behcet's disease (BD).\n\nIn this retrospective cohort study, we retrieved BD patients with definite diagnosis of COVID-19 infection. Demographic data, comorbidities, features related both to BD and COVID-19 infection, treatments, and outcomes were collected. Comparisons between patients with or without hospitalization were performed. All statistical analyzes were performed using SPSS version 25. We considered p < 0.05 statistically significant.\n\nWe identified 61 episodes of COVID-19 infection in 59 BD patients. The prevalence was 0.69%. The median age was 45 years (IQR = 20), and the median disease duration was 162 months (IQR = 195). BD features were similar except for higher rate of arterial involvement and positive pathergy test in infected patients. Thirty-five episodes (62.5%) happened in non-active patients; 39% had a comorbid disease. COVID manifestations were the same as the general population. Flu-like symptoms were the most common (85%), followed by fever (66%), ageusia/anosmia (56%), headache (51%), and pulmonary involvement (48%). There was no change in BD symptoms in 74%. Fifteen patients (25.4%) were hospitalized, and one patient (1.7%) died. Receiving glucocorticoids (p < 0.03) and cytotoxic drugs (p < 0.02) were associated with an increased rate of hospitalization.\n\nThe incidence of COVID-19 infection in BD patients was not higher than general population in Iran. They showed milder form of disease with lower morbidity and mortality rate. Most were on immunosuppressive drugs, or had a comorbidity apart from BD. No significant effect on BD course was shown. Key Points \u2022 The incidence of COVID-19 infection in patients with Behcet's disease is not higher. \u2022 They showed milder form of infection with lower morbidity and mortality rate. \u2022 No significant effect on Behcet's disease course was shown with COVID19 infection. \u2022 BD patients can be managed according to the guidelines used for general population.", "doi": "10.1007/s10067-021-06004-y", "pmid": "34842999", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10067-021-06004-y"}, {"db": "pmc", "key": "PMC8628030"}], "notes": [], "created": "2021-12-18T18:12:18.769Z", "modified": "2021-12-18T18:12:29.094Z"}, {"entity": "publication", "iuid": "22607e4c502043ae9c2d0bb4e98a8a8f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/22607e4c502043ae9c2d0bb4e98a8a8f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/22607e4c502043ae9c2d0bb4e98a8a8f"}}, "title": "COVID-19 Fear Among Pakistanis: Psychometric Evaluation of the Fear of COVID-19 Scale Using Item Response Theory and Confirmatory Factor Analysis.", "authors": [{"family": "Ullah", "given": "Irfan", "initials": "I", "orcid": "0000-0003-1100-101X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8d5a7e15ae6487cbdda0de3b2a531c3.json"}}, {"family": "Tahir", "given": "Muhammad Junaid", "initials": "MJ", "orcid": "0000-0002-0335-6681", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3192523e30b47e4ba6579ed8ab36661.json"}}, {"family": "Ali", "given": "Sajjad", "initials": "S", "orcid": "0000-0002-8024-5942", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26d9173903254605b87536aacb209621.json"}}, {"family": "Waseem", "given": "Rabia", "initials": "R"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA", "orcid": "0000-0002-1728-8966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6e65a5a97154d159a63cc2ce3f1b7a8.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-11-29", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "pages": "1-16", "issn-l": null}, "abstract": "The Fear of COVID-19 Scale (FCV-19S) assesses the fear of the novel coronavirus disease 2019 (COVID-19) and has been translated and validated into over 20 languages. The present study conducted confirmatory factor analysis (CFA) and item response theory (IRT) analyses on the FCV-19S among a sample of 937 Pakistani adults (mean [SD] age of 25.83 [11.80] years; 537 [57.3%] females). The CFA and IRT confirmed the unidimensionality of the FCV-19S. The Likert-type scale used in the FCV-19S was supported by the proper threshold orderings. Additionally, no DIF contrast had an absolute value larger than 0.5 regarding the participants' characteristics of gender, age, living status, and education in the IRT findings. The FCV-19S was found to be valid and reliable with strong psychometric properties among the Pakistani adult population.", "doi": "10.1007/s11469-021-00656-2", "pmid": "34867122", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "656"}, {"db": "pmc", "key": "PMC8628831"}], "notes": [], "created": "2021-12-13T06:07:01.885Z", "modified": "2021-12-13T06:07:20.741Z"}, {"entity": "publication", "iuid": "61ae5f5a56ba41f4909e80b7caa89fce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61ae5f5a56ba41f4909e80b7caa89fce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61ae5f5a56ba41f4909e80b7caa89fce"}}, "title": "A Survey of Psychiatric Healthcare Workers' Perception of Working Environment and Possibility to Recover Before and After the First Wave of COVID-19 in Sweden.", "authors": [{"family": "Alexiou", "given": "Eirini", "initials": "E"}, {"family": "Steingrimsson", "given": "Steinn", "initials": "S"}, {"family": "Akerstrom", "given": "Magnus", "initials": "M"}, {"family": "Jonsdottir", "given": "Ingibj\u00f6rg H", "initials": "IH"}, {"family": "Ahlstrom", "given": "Linda", "initials": "L"}, {"family": "Finizia", "given": "Caterina", "initials": "C"}, {"family": "Wijk", "given": "Helle", "initials": "H"}, {"family": "Degl'Innocenti", "given": "Alessio", "initials": "A"}], "type": "journal article", "published": "2021-11-29", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "770955", "issn-l": "1664-0640"}, "abstract": "Objective: This study aimed to investigate the impact of the first wave of the COVID-19 pandemic on perceived working environment, including the possibility to recover, among psychiatric healthcare workers (PHCWs) in comparison with pre-pandemic measures. Method: A link to an anonymous, web-based COVID-19 related survey was sent via email to all PHCWs at a university hospital in Sweden (n = 1,618) in September 2020. The response rate was 38% (566 of 1,507 eligible participants). Working environment survey responses collected in 2019 were used as pre-pandemic comparators. Statistical analyses were performed to assess overall impact over time on work demands, support, motivation, and recovery, stratified by professional role, and considering variables such as access to personal protective equipment. Results: The percentage of individuals responding negatively to statements about working environment increased significantly for most items after the first wave. Similarly, the increase of five of the investigated factors indicated a more negative perception of recovery during the pandemic. Registered nurses reported a greater negative impact of the pandemic on perceived working conditions and ability to recover than other professional groups. PHCWs working with patients with COVID-19 (35%) who reported being worried about becoming infected (12%) or infecting others (17%), or lacking adequate personal protective equipment (22%) were more negatively impacted regarding work environment-related items than those who did not. Conclusions: PHCWs' working environment and possibility for recovery were impacted by the first wave of the COVID-19 pandemic, nurses being most affected. Although psychiatric services do not directly care for patients with severe COVID-19 infection, the results from this study suggests that mental health services should also prepare for future pandemics.", "doi": "10.3389/fpsyt.2021.770955", "pmid": "34912253", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8666504"}], "notes": [], "created": "2021-12-18T17:48:55.226Z", "modified": "2022-01-04T15:36:57.557Z"}, {"entity": "publication", "iuid": "70c06bfda3fd453ea00196690a20d869", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70c06bfda3fd453ea00196690a20d869.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70c06bfda3fd453ea00196690a20d869"}}, "title": "The Meaning of Critical Illness for People Suffering From COVID-19: When a Frightening Unreality Becomes Reality.", "authors": [{"family": "Engstr\u00f6m", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0001-6244-6401", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f93844031da44a79bc89f3d73da4477f.json"}}, {"family": "Juuso", "given": "P\u00e4ivi", "initials": "P"}, {"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Nordin", "given": "Anna", "initials": "A"}, {"family": "Str\u00f6mb\u00e4ck", "given": "Ulrica", "initials": "U"}], "type": "journal article", "published": "2021-11-27", "journal": {"title": "Qual Health Res", "issn": "1049-7323", "pages": "10497323211050048", "issn-l": null}, "abstract": "The aim of this study was to elucidate the meaning of critical illness for people with COVID-19. This study used a qualitative design. Thirteen people who were critically ill with COVID-19 during 2020 and admitted to a COVID-19 intensive care unit in northern Sweden participated in the study. Data collection was conducted as individual interviews with a narrative approach, and data were analyzed with phenomenological hermeneutic interpretation. The participants did not think they would get critically ill with this unexpected illness. They experienced terrible nightmares where their relatives had been killed, and they missed their relatives both in their dreams and in reality, as they had not been allowed to be with them due to the virus. Gratefulness was described for surviving. Participants described thoughts of not being able to imagine going through this again. They felt fear and loneliness, as a terrifying unreality had become a reality.", "doi": "10.1177/10497323211050048", "pmid": "34839759", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T18:12:43.579Z", "modified": "2021-12-18T18:12:43.660Z"}, {"entity": "publication", "iuid": "41d9d59911dd4b5cbb0b4bf1de8af240", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41d9d59911dd4b5cbb0b4bf1de8af240.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41d9d59911dd4b5cbb0b4bf1de8af240"}}, "title": "Patients diagnosed with COVID-19 and treated with anakinra: a real-world study in the USA.", "authors": [{"family": "Rich", "given": "Carly", "initials": "C", "orcid": "0000-0003-4717-5855", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07ef31d5e3c64104813c74bdebd028c9.json"}}, {"family": "Eriksson", "given": "Daniel", "initials": "D"}, {"family": "Dolfi", "given": "Fabrizio", "initials": "F"}, {"family": "Jablonska", "given": "Katarzyna", "initials": "K"}, {"family": "Dabbous", "given": "Firas", "initials": "F"}, {"family": "Nazir", "given": "Jameel", "initials": "J"}], "type": "journal article", "published": "2021-11-27", "journal": {"title": "Clin Exp Immunol", "issn": "1365-2249", "issn-l": null}, "abstract": "Anakinra, a recombinant, non-glycosylated human interleukin (IL)-1 receptor antagonist, has been used in real-world clinical practice to manage hyperinflammation in COVID-19. This retrospective, observational study analyses USA hospital inpatient data of patients diagnosed with moderate/severe COVID-19 and treated with anakinra between 1 April and 31 August 2020. Of the 119 patients included in the analysis, 63.9% were male, 48.6% were of black ethnicity and the mean (standard deviation [SD]) age was 64.7 (12.5) years. Mean (SD) time from hospital admission to anakinra initiation was 7.3 (6.1) days. Following anakinra initiation, 73.1% of patients received antibiotics, 55.5% received antithrombotics, and 91.0% received corticosteroids. Overall, 64.7% of patients required intensive care unit (ICU) admittance, and 28.6% received mechanical ventilation following admission. Patients who did not require ICU admittance or who were discharged alive experienced a significantly shorter time between hospital admission and receiving anakinra treatment compared with those admitted to the ICU (5 vs 8 days; p = 0.002) or those who died in hospital (6 vs 9 days; p = 0.01). Patients with myocardial infarction or renal conditions were six times (p < 0.01) and three times (p = 0.01), respectively, more likely to die in hospital than be discharged alive. A longer time from hospital admission until anakinra treatment was associated with significantly higher mortality (p = 0.01). Findings from this real-world study suggest that a shorter time from hospital admission to anakinra treatment is associated with significantly lower ICU admissions and mortality among patients with moderate/severe COVID-19.", "doi": "10.1093/cei/uxab024", "pmid": "35020840", "labels": {"Category: Drug Discovery": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6445008"}], "notes": [], "created": "2022-01-13T20:56:01.552Z", "modified": "2022-01-13T20:56:01.634Z"}, {"entity": "publication", "iuid": "877c283b6bc944c2b65464cc5278954a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/877c283b6bc944c2b65464cc5278954a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/877c283b6bc944c2b65464cc5278954a"}}, "title": "COVID-19 and myocardial infarction - Authors' reply.", "authors": [{"family": "Katsoularis", "given": "Ioannis", "initials": "I"}, {"family": "Fonseca-Rodr\u00edguez", "given": "Osvaldo", "initials": "O"}, {"family": "Farrington", "given": "Paddy", "initials": "P"}, {"family": "Lindmark", "given": "Krister", "initials": "K"}, {"family": "Connolly", "given": "Anne-Marie Fors", "initials": "AF"}], "type": "letter", "published": "2021-11-27", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "398", "issue": "10315", "pages": "1964", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(21)02320-5", "pmid": "34838176", "labels": {"Type: Other": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8616566"}, {"db": "pii", "key": "S0140-6736(21)02320-5"}], "notes": [], "created": "2021-12-18T18:12:54.982Z", "modified": "2023-06-19T14:47:25.471Z"}, {"entity": "publication", "iuid": "978bd8de884f43a484e720b400afd240", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/978bd8de884f43a484e720b400afd240.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/978bd8de884f43a484e720b400afd240"}}, "title": "A multitask transfer learning framework for the prediction of virus-human protein-protein interactions.", "authors": [{"family": "Dong", "given": "Thi Ngan", "initials": "TN", "orcid": "0000-0002-3240-9068", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac25fc1b1e684ea8bfb683a927e62de0.json"}}, {"family": "Brogden", "given": "Graham", "initials": "G"}, {"family": "Gerold", "given": "Gisa", "initials": "G"}, {"family": "Khosla", "given": "Megha", "initials": "M"}], "type": "journal article", "published": "2021-11-27", "journal": {"title": "BMC Bioinformatics", "issn": "1471-2105", "volume": "22", "issue": "1", "pages": "572", "issn-l": null}, "abstract": "Viral infections are causing significant morbidity and mortality worldwide. Understanding the interaction patterns between a particular virus and human proteins plays a crucial role in unveiling the underlying mechanism of viral infection and pathogenesis. This could further help in prevention and treatment of virus-related diseases. However, the task of predicting protein-protein interactions between a new virus and human cells is extremely challenging due to scarce data on virus-human interactions and fast mutation rates of most viruses.\n\nWe developed a multitask transfer learning approach that exploits the information of around 24 million protein sequences and the interaction patterns from the human interactome to counter the problem of small training datasets. Instead of using hand-crafted protein features, we utilize statistically rich protein representations learned by a deep language modeling approach from a massive source of protein sequences. Additionally, we employ an additional objective which aims to maximize the probability of observing human protein-protein interactions. This additional task objective acts as a regularizer and also allows to incorporate domain knowledge to inform the virus-human protein-protein interaction prediction model.\n\nOur approach achieved competitive results on 13 benchmark datasets and the case study for the SARS-COV-2 virus receptor. Experimental results show that our proposed model works effectively for both virus-human and bacteria-human protein-protein interaction prediction tasks. We share our code for reproducibility and future research at https://git.l3s.uni-hannover.de/dong/multitask-transfer .", "doi": "10.1186/s12859-021-04484-y", "pmid": "34837942", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12859-021-04484-y"}, {"db": "pmc", "key": "PMC8626732"}], "notes": [], "created": "2021-12-18T18:13:13.723Z", "modified": "2021-12-18T18:13:13.776Z"}, {"entity": "publication", "iuid": "461999d72d1b4338a4999a7334412c17", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/461999d72d1b4338a4999a7334412c17.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/461999d72d1b4338a4999a7334412c17"}}, "title": "Post-Translational Modification of HMGB1 Disulfide Bonds in Stimulating and Inhibiting Inflammation.", "authors": [{"family": "Andersson", "given": "Ulf", "initials": "U", "orcid": "0000-0003-0316-3860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee9bbcb5111f446e99ff8b68c4027f5c.json"}}, {"family": "Tracey", "given": "Kevin J", "initials": "KJ"}, {"family": "Yang", "given": "Huan", "initials": "H"}], "type": "journal article", "published": "2021-11-26", "journal": {"title": "Cells", "issn": "2073-4409", "volume": "10", "issue": "12", "issn-l": null}, "abstract": "High mobility group box 1 protein (HMGB1), a highly conserved nuclear DNA-binding protein, is a \"damage-associated molecular pattern\" molecule (DAMP) implicated in both stimulating and inhibiting innate immunity. As reviewed here, HMGB1 is an oxidation-reduction sensitive DAMP bearing three cysteines, and the post-translational modification of these residues establishes its proinflammatory and anti-inflammatory activities by binding to different extracellular cell surface receptors. The redox-sensitive signaling mechanisms of HMGB1 also occupy an important niche in innate immunity because HMGB1 may carry other DAMPs and pathogen-associated molecular pattern molecules (PAMPs). HMGB1 with DAMP/PAMP cofactors bind to the receptor for advanced glycation end products (RAGE) which internalizes the HMGB1 complexes by endocytosis for incorporation in lysosomal compartments. Intra-lysosomal HMGB1 disrupts lysosomal membranes thereby releasing the HMGB1-transported molecules to stimulate cytosolic sensors that mediate inflammation. This HMGB1-DAMP/PAMP cofactor pathway slowed the development of HMGB1-binding antagonists for diagnostic or therapeutic use. However, recent discoveries that HMGB1 released from neurons mediates inflammation via the TLR4 receptor system, and that cancer cells express fully oxidized HMGB1 as an immunosuppressive mechanism, offer new paths to targeting HMGB1 for inflammation, pain, and cancer.", "doi": "10.3390/cells10123323", "pmid": "34943830", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "cells10123323"}, {"db": "pmc", "key": "PMC8699546"}], "notes": [], "created": "2022-01-03T15:35:56.729Z", "modified": "2022-01-03T15:35:56.782Z"}, {"entity": "publication", "iuid": "abc9c029bee04f64b31151f71dd181fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abc9c029bee04f64b31151f71dd181fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abc9c029bee04f64b31151f71dd181fa"}}, "title": "COVID-19-specific metabolic imprint yields insights into multiorgan system perturbations.", "authors": [{"family": "Cornillet", "given": "Martin", "initials": "M"}, {"family": "Strunz", "given": "Benedikt", "initials": "B"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Ponzetta", "given": "Andrea", "initials": "A"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Muvva", "given": "Jagadeeswara Rao", "initials": "JR"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Chambers", "given": "Benedict J", "initials": "BJ"}, {"family": "Dzidic", "given": "Majda", "initials": "M"}, {"family": "Filipovic", "given": "Iva", "initials": "I"}, {"family": "Gorin", "given": "Jean-Baptiste", "initials": "JB"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Hertwig", "given": "Laura", "initials": "L"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Kokkinou", "given": "Efthymia", "initials": "E"}, {"family": "Kvedaraite", "given": "Egle", "initials": "E"}, {"family": "Lourda", "given": "Magda", "initials": "M"}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J"}, {"family": "Maucourant", "given": "Christopher", "initials": "C"}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A"}, {"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Perez-Potti", "given": "Andr\u00e9", "initials": "A"}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Sandberg", "given": "John Tyler", "initials": "JT"}, {"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "Svensson", "given": "Mattias", "initials": "M"}, {"family": "Varnaite", "given": "Renata", "initials": "R"}, {"family": "Karolinska KI/K COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4691d38f3268433696d7c65ea235a12b.json"}}], "type": "journal article", "published": "2021-11-26", "journal": {"title": "Eur J Immunol", "issn": "1521-4141", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Corona disease 2019 (COVID-19) affects multiple organ systems. Recent studies have indicated perturbations in the circulating metabolome linked to COVID-19 severity. However, several questions pertain with respect to the metabolome in COVID-19. We performed an in-depth assessment of 1129 unique metabolites in 27 hospitalized COVID-19 patients and integrated results with large-scale proteomic and immunology data to capture multiorgan system perturbations. More than half of the detected metabolic alterations in COVID-19 were driven by patient-specific confounding factors ranging from comorbidities to xenobiotic substances. Systematically adjusting for this, a COVID-19-specific metabolic imprint was defined which, over time, underwent a switch in response to severe acute respiratory syndrome coronavirus-2 seroconversion. Integration of the COVID-19 metabolome with clinical, cellular, molecular, and immunological severity scales further revealed a network of metabolic trajectories aligned with multiple pathways for immune activation, and organ damage including neurological inflammation and damage. Altogether, this resource refines our understanding of the multiorgan system perturbations in severe COVID-19 patients.", "doi": "10.1002/eji.202149626", "pmid": "34837225", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null}, "xrefs": [{"db": "URL", "key": "http://www.covid19cellatlas.com", "description": "http://www.covid19cellatlas.com"}], "notes": [], "created": "2021-11-29T06:50:01.953Z", "modified": "2022-02-14T14:51:25.826Z"}, {"entity": "publication", "iuid": "d57da8e8898541a99e1eb3eeec229a67", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d57da8e8898541a99e1eb3eeec229a67.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d57da8e8898541a99e1eb3eeec229a67"}}, "title": "Working conditions in the long-term care sector: A comparative study of migrant and native workers in Austria and Sweden.", "authors": [{"family": "Simmons", "given": "Cassandra", "initials": "C", "orcid": "0000-0002-3053-4244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d023b23170f4381b3b56e2d0299760c.json"}}, {"family": "Rodrigues", "given": "Ricardo", "initials": "R", "orcid": "0000-0001-8438-4184", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93f762464a28446cadf03fe7c1f3a744.json"}}, {"family": "Szebehely", "given": "Marta", "initials": "M", "orcid": "0000-0001-6956-7329", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f91b8962e79467695591ce7db084b3d.json"}}], "type": "journal article", "published": "2021-11-25", "journal": {"title": "Health Soc Care Community", "issn": "1365-2524", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Increased demand for long-term care (LTC) services alongside precarious working conditions has resulted in labour shortages in the LTC sector, which has led to an increasing share of workers of migrant origin filling these jobs. Previous research on migrant care workers has also highlighted the seeming gap in working conditions relative to native workers. However, lack of disaggregated data on migrant and native care workers, alongside single-case studies, may have concealed potential disadvantages faced by certain groups and insufficiently accounted for differences in migration regimes and organisation of LTC sectors. To address these gaps, we carried out a comparative study on various working conditions of migrant and native LTC workers in Austria and Sweden. Using the international Nordcare survey on care sector working conditions, carried out in Austria in 2017 (n = 792) and in Sweden in 2015 (n = 708), we employed t-tests and multivariate logistic regressions to compare the working conditions of migrant and native carers in home and residential care in each country. We found that worse working conditions in Sweden compared to Austria may be explained by differences in training requirements of the LTC workforce and the relatively large for-profit private sector. Country of origin also plays a paramount role in the differences in working conditions experienced by migrants compared to native care workers, with non-European migrants being more likely to face a number of precarious working conditions. Our findings highlight the need to continue addressing precarious working conditions across the sector, particularly during the COVID-19 pandemic where poor working conditions have been linked to increased COVID-related deaths in nursing homes. Our findings also emphasise the importance of policies that consider the various challenges experienced by different migrant groups in the LTC sector, who may particularly be at risk of presenteeism during the COVID-19 pandemic.", "doi": "10.1111/hsc.13657", "pmid": "34825423", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T18:18:50.075Z", "modified": "2022-11-22T05:45:43.886Z"}, {"entity": "publication", "iuid": "7a72853feee044088b4630148605d8f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a72853feee044088b4630148605d8f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a72853feee044088b4630148605d8f8"}}, "title": "Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome.", "authors": [{"family": "Masood", "given": "Kiran Iqbal", "initials": "KI"}, {"family": "Yameen", "given": "Maliha", "initials": "M"}, {"family": "Ashraf", "given": "Javeria", "initials": "J"}, {"family": "Shahid", "given": "Saba", "initials": "S"}, {"family": "Mahmood", "given": "Syed Faisal", "initials": "SF"}, {"family": "Nasir", "given": "Asghar", "initials": "A"}, {"family": "Nasir", "given": "Nosheen", "initials": "N"}, {"family": "Jamil", "given": "Bushra", "initials": "B"}, {"family": "Ghanchi", "given": "Najia Karim", "initials": "NK"}, {"family": "Khanum", "given": "Iffat", "initials": "I"}, {"family": "Razzak", "given": "Safina Abdul", "initials": "SA"}, {"family": "Kanji", "given": "Akbar", "initials": "A"}, {"family": "Hussain", "given": "Rabia", "initials": "R"}, {"family": "E Rottenberg", "given": "Martin", "initials": "M"}, {"family": "Hasan", "given": "Zahra", "initials": "Z"}], "type": "journal article", "published": "2021-11-25", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "22958", "issn-l": "2045-2322"}, "abstract": "Understanding key host protective mechanisms against SARS-CoV-2 infection can help improve treatment modalities for COVID-19. We used a blood transcriptome approach to study biomarkers associated with differing severity of COVID-19, comparing severe and mild Symptomatic disease with Asymptomatic COVID-19 and uninfected Controls. There was suppression of antigen presentation but upregulation of inflammatory and viral mRNA translation associated pathways in Symptomatic as compared with Asymptomatic cases. In severe COVID-19, CD177 a neutrophil marker, was upregulated while interferon stimulated genes (ISGs) were downregulated. Asymptomatic COVID-19 cases displayed upregulation of ISGs and humoral response genes with downregulation of ICAM3 and TLR8. Compared across the COVID-19 disease spectrum, we found type I interferon (IFN) responses to be significantly upregulated (IFNAR2, IRF2BP1, IRF4, MAVS, SAMHD1, TRIM1), or downregulated (SOCS3, IRF2BP2, IRF2BPL) in Asymptomatic as compared with mild and severe COVID-19, with the dysregulation of an increasing number of ISGs associated with progressive disease. These data suggest that initial early responses against SARS-CoV-2 may be effectively controlled by ISGs. Therefore, we hypothesize that treatment with type I interferons in the early stage of COVID-19 may limit disease progression by limiting SARS-CoV-2 in the host.", "doi": "10.1038/s41598-021-02489-4", "pmid": "34824360", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-02489-4"}, {"db": "pmc", "key": "PMC8617268"}], "notes": [], "created": "2021-12-18T18:19:04.143Z", "modified": "2021-12-18T18:19:04.157Z"}, {"entity": "publication", "iuid": "2d5318adb0dd496d8f88c3835268cc12", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d5318adb0dd496d8f88c3835268cc12.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d5318adb0dd496d8f88c3835268cc12"}}, "title": "Thrombosis and Bleeding After Implementation of an Intermediate-Dose Prophylactic Anticoagulation Protocol in ICU Patients With COVID-19: A Multicenter Screening Study.", "authors": [{"family": "Al-Abani", "given": "Kais", "initials": "K", "orcid": "0000-0002-1789-1538", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a63c8ea9d2b4263817a82795ff41e55.json"}}, {"family": "Kilhamn", "given": "Naima", "initials": "N", "orcid": "0000-0002-7797-9558", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4eef69c580c944989ee65bdf7a0cdb06.json"}}, {"family": "Maret", "given": "Eva", "initials": "E"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J", "orcid": "0000-0001-8739-7896", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c2fb174ab842c8809900877de8c008.json"}}], "type": "journal article", "published": "2021-11-25", "journal": {"title": "J Intensive Care Med", "issn": "1525-1489", "pages": "8850666211051960", "issn-l": null}, "abstract": "Thrombosis and bleeding after implementation of an intermediate-dose prophylactic anticoagulation protocol in intensive care unit (ICU) patients with coronavirus disease 2019 (COVID-19): a multicenter screening study Background: Venous thromboembolism (VTE) is common among critically ill patients with COVID-19. Information regarding VTE prevalence and bleeding complications after implementation of intermediate-dose prophylactic anticoagulation in such patients is, however, limited. Methods: We performed a prospective, observational study in 6 ICUs in 2 university-affiliated teaching hospitals in Sweden. After implementation of an intermediate-dose prophylactic anticoagulation protocol, we performed ultrasound screening for proximal lower-extremity deep vein thrombosis (DVT) and collected routine computed tomography pulmonary angiography exam results. Results: A total of 100 COVID-19 patients were included from June 21, 2020, through February 18, 2021. During a median follow-up of 120 (IQR, 89-134) days, we found VTE in 37 patients with the majority (78.4%) being diagnosed after ICU arrival. Overall, 20 patients had proximal lower-extremity DVT with 95% being detected on ultrasound screening; 22 patients had pulmonary vascular thrombosis; and 4 patients had venous thrombosis at other sites. A total of 6 patients had both proximal lower-extremity DVT and pulmonary vascular thrombosis. On univariate logistic regression analysis of 14 baseline characteristics, only pre-existing heart failure was associated with VTE (OR 4.67, 95% CI 1.13-19.34). Major and non-major bleeding occurred in 10 and 18 patients, respectively. Conclusions: In our cohort of ICU patients with COVID-19, we observed a high prevalence of VTE and bleeding complications after implementation of intermediate-dose anticoagulation. In approximately half of patients, VTE was identified on screening ultrasound.", "doi": "10.1177/08850666211051960", "pmid": "34821162", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T13:05:15.915Z", "modified": "2021-12-18T18:20:59.763Z"}, {"entity": "publication", "iuid": "e782f8c5f6f74285a6d78de609f94e64", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e782f8c5f6f74285a6d78de609f94e64.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e782f8c5f6f74285a6d78de609f94e64"}}, "title": "Associations between compliance with covid-19 public health recommendations and perceived contagion in others: a self-report study in Swedish university students.", "authors": [{"family": "Andersson", "given": "Claes", "initials": "C", "orcid": "0000-0001-9819-2474", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2dce70574f549a6badd1af98fad130a.json"}}, {"family": "Bendtsen", "given": "Marcus", "initials": "M"}, {"family": "Molander", "given": "Olof", "initials": "O"}, {"family": "Granlund", "given": "Lilian", "initials": "L"}, {"family": "Topooco", "given": "Naira", "initials": "N"}, {"family": "Engstr\u00f6m", "given": "Karin", "initials": "K"}, {"family": "Lindfors", "given": "Petra", "initials": "P"}, {"family": "Berman", "given": "Anne H", "initials": "AH"}], "type": "journal article", "published": "2021-11-25", "journal": {"title": "BMC Res Notes", "issn": "1756-0500", "volume": "14", "issue": "1", "pages": "429", "issn-l": null}, "abstract": "During the COVID pandemic, government authorities worldwide have tried to limit the spread of the virus. Sweden's distinctive feature was the use of voluntary public health recommendations. Few studies have evaluated the effectiveness of this strategy. Based on data collected in the spring of 2020, this study explored associations between compliance with recommendations and observed symptoms of contagion in others, using self-report data from university students.\n\nCompliance with recommendations ranged between 69.7 and 95.7 percent. Observations of moderate symptoms of contagion in \"Someone else I have had contact with\" and \"Another person\" were markedly associated with reported self-quarantine, which is the most restrictive recommendation, complied with by 81.2% of participants. Uncertainty regarding the incidence and severity of contagion in cohabitants was markedly associated with the recommendation to avoid public transportation, a recommendation being followed by 69.7%. It is concluded that students largely followed the voluntary recommendations implemented in Sweden, suggesting that coercive measures were not necessary. Compliance with recommendations were associated with the symptoms students saw in others, and with the perceived risk of contagion in the student's immediate vicinity. It is recommended that voluntary recommendations should stress personal relevance, and that close relatives are at risk.", "doi": "10.1186/s13104-021-05848-6", "pmid": "34823585", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8613723"}, {"db": "pii", "key": "10.1186/s13104-021-05848-6"}], "notes": [], "created": "2021-11-26T13:04:20.837Z", "modified": "2023-06-19T14:24:54.892Z"}, {"entity": "publication", "iuid": "d50564289b6b497dbcea278b78f1c958", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d50564289b6b497dbcea278b78f1c958.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d50564289b6b497dbcea278b78f1c958"}}, "title": "The Paradox of Political Accountability and Deficits in the Preconditions for Service Delivery in Elderly Care: A Qualitative Study of Swedish Politicians", "authors": [{"family": "Porter", "given": "Susann", "initials": "S"}, {"family": "Muhonen", "given": "Tuija", "initials": "T"}], "type": "journal-article", "published": "2021-11-24", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "23", "pages": "12350", "issn-l": null}, "abstract": null, "doi": "10.3390/ijerph182312350", "pmid": null, "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:56:32.225Z", "modified": "2021-12-12T06:56:32.244Z"}, {"entity": "publication", "iuid": "032f79d2b198402daefeca79ebaacd96", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/032f79d2b198402daefeca79ebaacd96.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/032f79d2b198402daefeca79ebaacd96"}}, "title": "Impact of the Covid-19 pandemic on primary care utilization: evidence from Sweden using national register data.", "authors": [{"family": "Ekman", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0001-7630-7904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1f4d8ed39cc483a802c179c1f37c53d.json"}}, {"family": "Arvidsson", "given": "Eva", "initials": "E"}, {"family": "Thulesius", "given": "Hans", "initials": "H"}, {"family": "Wilkens", "given": "Jens", "initials": "J"}, {"family": "Cronberg", "given": "Olof", "initials": "O"}], "type": "journal article", "published": "2021-11-24", "journal": {"title": "BMC Res Notes", "issn": "1756-0500", "volume": "14", "issue": "1", "pages": "424", "issn-l": null}, "abstract": "To analyze changes in primary care utilization as a result of the Covid-19 pandemic. Swedish national register data from 2019 to 2020 on utilization of services were used to compare overall utilization levels and across types of contacts and patient groups. A specific objective was to assess the extent to which remote types of patient consultations were able to compensate for any observed fall in on-site visits. Data were stratified by sex and age to investigate any demographic pattern.\n\nFindings show significant reductions in overall utilization of services as the pandemic occurred in the first quarter of 2020. On-site visits fell during the first wave of the pandemic and rebounded thereafter. Patients over 65 years of age appear to have reduced utilization to a larger extent compared with younger groups. Simultaneously, remote contacts increased from around 12% before the pandemic to 17% of the total number of consultations. However, the net effect of changes in service utilization suggests an overall reduction of around 12 percent in the number of primary care consultations as a result of the pandemic. No differences between men and women were observed. Further research will continue to monitor changes in primary care utilization as the pandemic continues.", "doi": "10.1186/s13104-021-05839-7", "pmid": "34819161", "labels": {"Type: Journal article": null, "Topics: Register-based research": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13104-021-05839-7"}, {"db": "pmc", "key": "PMC8611625"}], "notes": [], "created": "2021-11-26T13:05:55.405Z", "modified": "2021-12-18T18:21:41.694Z"}, {"entity": "publication", "iuid": "f11c8ef92e004250bd551f84fd6c7803", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f11c8ef92e004250bd551f84fd6c7803.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f11c8ef92e004250bd551f84fd6c7803"}}, "title": "The impact of COVID-19 on cancer care and oncology clinical research: an experts' perspective.", "authors": [{"family": "Sessa", "given": "C", "initials": "C"}, {"family": "Cortes", "given": "J", "initials": "J"}, {"family": "Conte", "given": "P", "initials": "P"}, {"family": "Cardoso", "given": "F", "initials": "F"}, {"family": "Choueiri", "given": "T", "initials": "T"}, {"family": "Dummer", "given": "R", "initials": "R"}, {"family": "Lorusso", "given": "P", "initials": "P"}, {"family": "Ottmann", "given": "O", "initials": "O"}, {"family": "Ryll", "given": "B", "initials": "B"}, {"family": "Mok", "given": "T", "initials": "T"}, {"family": "Tempero", "given": "M", "initials": "M"}, {"family": "Comis", "given": "S", "initials": "S"}, {"family": "Oliva", "given": "C", "initials": "C"}, {"family": "Peters", "given": "S", "initials": "S"}, {"family": "Tabernero", "given": "J", "initials": "J"}], "type": "journal article", "published": "2021-11-23", "journal": {"title": "ESMO Open", "issn": "2059-7029", "volume": "7", "issue": "1", "pages": "100339", "issn-l": null}, "abstract": "The coronavirus disease-19 (COVID-19) pandemic promises to have lasting impacts on cancer clinical trials that could lead to faster patient access to new treatments. In this article, an international panel of oncology experts discusses the lasting impacts of the pandemic on oncology clinical trials and proposes solutions for clinical trial stakeholders, with the support of recent data on worldwide clinical trials collected by IQVIA. These lasting impacts and proposed solutions encompass three topic areas. Firstly, acceleration and implementation of new operational approaches to oncology trials with patient-centric, fully decentralized virtual approaches that include remote assessments via telemedicine and remote devices. Geographical differences in the uptake of remote technology, including telemedicine, are discussed in the article, focusing on the impact of the local adoption of new operational approaches. Secondly, innovative clinical trials. The pandemic has highlighted the need for new trial designs that accelerate research and limit risks and burden for patients while driving optimization of clinical trial objectives and endpoints, while testing is being minimized. Areas of considerations for clinical trial stakeholders are discussed in detail. In addition, the COVID-19 pandemic has exposed the underrepresentation of minority groups in clinical trials; the approach for oncology clinical trials to improve generalizability of efficacy and outcomes data is discussed. Thirdly, a new problem-focused collaborative framework between oncology trial stakeholders, including decision makers, to leverage and further accelerate the innovative approaches in clinical research developed during the COVID-19 pandemic. This could shorten timelines for patient access to new treatments by addressing the cultural and technological barriers to adopting new operational approaches and innovative clinical trials. The role of the different stakeholders is described, with the aim of making COVID-19 a catalyst for positive change in oncology clinical research and eventually in cancer care.", "doi": "10.1016/j.esmoop.2021.100339", "pmid": "34953404", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2059-7029(21)00301-X"}, {"db": "pmc", "key": "PMC8608656"}], "notes": [], "created": "2022-01-04T15:25:35.957Z", "modified": "2022-01-04T15:25:35.963Z"}, {"entity": "publication", "iuid": "e67e39136bfb4bfbb52f5866da426b32", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e67e39136bfb4bfbb52f5866da426b32.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e67e39136bfb4bfbb52f5866da426b32"}}, "title": "Self-scored impairments in functioning and disability in post-COVID syndrome following mild COVID-19 infection.", "authors": [{"family": "Norrefalk", "given": "Jan-Rickard", "initials": "JR", "orcid": "0000-0002-7070-3268", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24718b50907344ec9053bfc5d8495f19.json"}}, {"family": "Borg", "given": "Kristian", "initials": "K"}, {"family": "Bileviciute-Ljungar", "given": "Indre", "initials": "I"}], "type": "journal article", "published": "2021-11-23", "journal": {"title": "J Rehabil Med", "issn": "1651-2081", "issn-l": null, "volume": "53", "issue": "11 (November)", "pages": "jrm00239"}, "abstract": "To investigate functioning, activity and disability in people with post-COVID syndrome.\n\nCross-sectional.\n\nParticipants were recruited online via Facebook and a stakeholders' organization for post-COVID syndrome in Sweden.\n\nSociodemographic data and International Classification of Functioning, Disability and Health (ICF)-based questionnaire were collected via an online platform and analysed.\n\nA total of 100 participants were included (mean age 44.5 years, 82% women, 61% with higher education, and 56% working full- or part-time). For the ICF component Body Functions, the most impaired functions were: fatigability and energy drive (98-99%); higher cognitive functions (74-94%); sleep functions (98%); muscle functions (93%); respiratory functions (92%); heart functions (82%); emotional functions (80%); sexual functions (77%); pain problems (56-90%); and thermoregulatory functions (68%). For the component Activity, the most frequent limitations were: handling stressful situations (98%); remunerative employment (95%); recreation and leisure (94%); climbing the stairs (94%); doing housework (84%); and informal socializing (64%). The most frequent degrees of impairment/limitations were light and moderate, except for severe-complete for fatigue, higher cognitive functions, multitasking, handling stressful situations; and recreation and leisure activities.\n\nPost-COVID syndrome following a mild COVID-19 infection can result in impaired body functions and activities. These results support the importance of a multidisciplinary rehabilitation approach for these patients.", "doi": "10.2340/jrm.v53.188", "pmid": "34643243", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC8638742"}], "notes": [], "created": "2021-10-21T05:08:19.835Z", "modified": "2023-06-19T15:16:57.208Z"}, {"entity": "publication", "iuid": "2864668bd1e647ecbd7fe29293402ec6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2864668bd1e647ecbd7fe29293402ec6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2864668bd1e647ecbd7fe29293402ec6"}}, "title": "Risk of severe COVID-19 and mortality in patients with established chronic liver disease: a nationwide matched cohort study.", "authors": [{"family": "Simon", "given": "Tracey G", "initials": "TG"}, {"family": "Hagstr\u00f6m", "given": "Hannes", "initials": "H"}, {"family": "Sharma", "given": "Rajani", "initials": "R"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Roelstraete", "given": "Bjorn", "initials": "B"}, {"family": "Larsson", "given": "Emma", "initials": "E"}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "journal article", "published": "2021-11-23", "journal": {"title": "BMC Gastroenterol", "issn": "1471-230X", "volume": "21", "issue": "1", "pages": "439", "issn-l": null}, "abstract": "Some, but not all, prior studies have suggested that patients with chronic liver disease are at increased risk of contracting COVID-19 and developing more severe disease. However, nationwide data are lacking from well-phenotyped cohorts with liver histology and comparisons to matched general population controls.\n\nWe conducted a nationwide cohort study of all Swedish adults with chronic liver disease (CLD) confirmed by liver biopsy between 1966 and 2017 (n = 42,320), who were alive on February 1, 2020. CLD cases were matched to \u2264 5 population comparators by age, sex, calendar year and county (n = 182,147). Using Cox regression, we estimated multivariable-adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for COVID-19 hospitalization and severe COVID-19 (intensive care admission or death due to COVID-19).\n\nBetween February 1 and July 31, 2020, 161 (0.38%) CLD patients and 435 (0.24%) general population controls were hospitalized with COVID-19 (aHR = 1.36, 95% CI = 1.11-1.66), while 65 (0.15%) CLD patients and 191 (0.10%) controls developed severe COVID-19 (aHR = 1.08, 95% CI = 0.79-1.48). Results were similar in patients with CLD due to alcohol use, nonalcoholic fatty liver disease, viral hepatitis, autoimmune hepatitis, and other etiologies. Among patients with cirrhosis (n = 2549), the aHRs for COVID-19 hospitalization and for severe COVID-19 were 1.08 (95% CI 0.48-2.40) and 1.23 (95% CI = 0.37-4.04), respectively, compared to controls. Moreover, among all patients diagnosed with COVID-19, the presence of underlying CLD was not associated with increased mortality (aHR = 0.85, 95% CI = 0.61-1.19).\n\nIn this nationwide cohort, patients with CLD had a higher risk of hospitalization for COVID-19 compared to the general population, but they did not have an increased risk of developing severe COVID-19.", "doi": "10.1186/s12876-021-02017-8", "pmid": "34814851", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12876-021-02017-8"}, {"db": "pmc", "key": "PMC8609512"}], "notes": [], "created": "2021-11-26T13:18:35.808Z", "modified": "2021-12-10T19:35:57.119Z"}, {"entity": "publication", "iuid": "35aa3cd093fd45d89865f8821d247ed6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/35aa3cd093fd45d89865f8821d247ed6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/35aa3cd093fd45d89865f8821d247ed6"}}, "title": "Changes in young adults' mental well-being before and during the early stage of the COVID-19 pandemic: disparities between ethnic groups in Germany.", "authors": [{"family": "Plenty", "given": "Stephanie", "initials": "S", "orcid": "0000-0001-7994-4829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4ecdc074a5e4829a9938e329048169c.json"}}, {"family": "Bracegirdle", "given": "Chloe", "initials": "C"}, {"family": "Dollmann", "given": "J\u00f6rg", "initials": "J"}, {"family": "Spiegler", "given": "Olivia", "initials": "O"}], "type": "journal article", "published": "2021-11-23", "journal": {"title": "Child Adolesc Psychiatry Ment Health", "issn": "1753-2000", "volume": "15", "issue": "1", "pages": "69", "issn-l": null}, "abstract": "The COVID-19 pandemic resulted in substantial disruptions to the daily lives of young people. Yet knowledge is lacking about changes in mental well-being among young adults, whether those from ethnic minorities were more adversely impacted by the pandemic than the ethnic majority, and the extent to which pandemic-related stressors contributed to any declines in mental well-being.\n\nWe draw on nationally representative German CILS4COVID data, collected early in the pandemic (N = 3517, Mage = 25). Respondents provided information on mental well-being (psychosomatic complaints, anxiety, depression, life satisfaction) and exposure to pandemic-related stressors (financial worries, health worries, discrimination, contact with COVID-19). Responses on mental well-being were matched to responses from two pre-pandemic waves. Individual fixed effects regressions examined ethnic group differences in changes in mental well-being prior to, and at the early stage of, the pandemic. Path analysis tested the role of pandemic-related stressors in declines in mental well-being.\n\nOverall, young adults' mental well-being had improved at the pandemic assessment compared to pre-pandemic assessments, and few ethnic group differences in changes were found. However, greater pandemic-related stressors were associated with worsened mental well-being at the pandemic assessment. Among Asian minorities, indirect effects were found on anxiety via health worries, and on depression via health worries and discrimination. For Turkish, Middle Eastern and African minorities, indirect effects on anxiety and depression were found via health worries.\n\nWe did not find widespread declines in mental well-being among young adults at the early stage of the pandemic, and changes in mental well-being prior to and at the early stage of the pandemic were mostly similar across ethnic German and minority groups. Nevertheless, pandemic-related stressors posed risks for young adults' mental well-being, particularly increased discrimination and health worries among Asian minorities, and health worries among Turkish, Middle Eastern and African minorities.", "doi": "10.1186/s13034-021-00418-x", "pmid": "34814926", "labels": {"Type: Journal article": null, "Topics: Register-based research": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13034-021-00418-x"}, {"db": "pmc", "key": "PMC8609988"}], "notes": [], "created": "2021-11-26T13:17:39.305Z", "modified": "2021-12-18T18:23:44.625Z"}, {"entity": "publication", "iuid": "d1fc8ca94c4b47b8ad6d10438d522bb7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1fc8ca94c4b47b8ad6d10438d522bb7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1fc8ca94c4b47b8ad6d10438d522bb7"}}, "title": "COVID-19 Vaccine Hesitancy in the United States: A Systematic Review", "authors": [{"family": "Yasmin", "given": "Farah", "initials": "F"}, {"family": "Najeeb", "given": "Hala", "initials": "H"}, {"family": "Moeed", "given": "Abdul", "initials": "A"}, {"family": "Naeem", "given": "Unaiza", "initials": "U"}, {"family": "Asghar", "given": "Muhammad Sohaib", "initials": "MS"}, {"family": "Chughtai", "given": "Najeeb Ullah", "initials": "NU"}, {"family": "Yousaf", "given": "Zohaib", "initials": "Z"}, {"family": "Seboka", "given": "Binyam Tariku", "initials": "BT"}, {"family": "Ullah", "given": "Irfan", "initials": "I"}, {"family": "Lin", "given": "Chung Ying", "initials": "CY"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal-article", "published": "2021-11-23", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2021.770985", "pmid": null, "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:52:36.907Z", "modified": "2021-12-12T06:53:00.510Z"}, {"entity": "publication", "iuid": "c4e922a935614f2084722b199ef6635c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c4e922a935614f2084722b199ef6635c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c4e922a935614f2084722b199ef6635c"}}, "title": "A Genetic Trap in Yeast for Inhibitors of SARS-CoV-2 Main Protease.", "authors": [{"family": "Alalam", "given": "Hanna", "initials": "H"}, {"family": "Sigurdard\u00f3ttir", "given": "Sunniva", "initials": "S"}, {"family": "Bourgard", "given": "Catarina", "initials": "C"}, {"family": "Tiukova", "given": "Ievgeniia", "initials": "I", "orcid": "0000-0002-0408-3515", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b86de4d9336b48daa3cd8cd3d2420573.json"}}, {"family": "King", "given": "Ross D", "initials": "RD"}, {"family": "Gr\u00f8tli", "given": "Morten", "initials": "M", "orcid": "0000-0003-3621-4222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0039e14b21d5401a833de03544270f70.json"}}, {"family": "Sunnerhagen", "given": "Per", "initials": "P", "orcid": "0000-0002-0967-8729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89127120ae8b43bea9681b7eadf1872b.json"}}], "type": "journal article", "published": "2021-11-23", "journal": {"title": "mSystems", "issn": "2379-5077", "pages": "e0108721", "issn-l": null}, "abstract": "The ongoing COVID-19 pandemic urges searches for antiviral agents that can block infection or ameliorate its symptoms. Using dissimilar search strategies for new antivirals will improve our overall chances of finding effective treatments. Here, we have established an experimental platform for screening of small molecule inhibitors of the SARS-CoV-2 main protease in Saccharomyces cerevisiae cells, genetically engineered to enhance cellular uptake of small molecules in the environment. The system consists of a fusion of the Escherichia coli toxin MazF and its antitoxin MazE, with insertion of a protease cleavage site in the linker peptide connecting the MazE and MazF moieties. Expression of the viral protease confers cleavage of the MazEF fusion, releasing the MazF toxin from its antitoxin, resulting in growth inhibition. In the presence of a small molecule inhibiting the protease, cleavage is blocked and the MazF toxin remains inhibited, promoting growth. The system thus allows positive selection for inhibitors. The engineered yeast strain is tagged with a fluorescent marker protein, allowing precise monitoring of its growth in the presence or absence of inhibitor. We detect an established main protease inhibitor by a robust growth increase, discernible down to 1 \u03bcM. The system is suitable for robotized large-scale screens. It allows in vivo evaluation of drug candidates and is rapidly adaptable for new variants of the protease with deviant site specificities. IMPORTANCE The COVID-19 pandemic may continue for several years before vaccination campaigns can put an end to it globally. Thus, the need for discovery of new antiviral drug candidates will remain. We have engineered a system in yeast cells for the detection of small molecule inhibitors of one attractive drug target of SARS-CoV-2, its main protease, which is required for viral replication. The ability to detect inhibitors in live cells brings the advantage that only compounds capable of entering the cell and remain stable there will score in the system. Moreover, because of its design in yeast cells, the system is rapidly adaptable for tuning the detection level and eventual modification of the protease cleavage site in the case of future mutant variants of the SARS-CoV-2 main protease or even for other proteases.", "doi": "10.1128/mSystems.01087-21", "pmid": "34812651", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Funder: VR": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC8609969"}], "notes": [], "created": "2021-11-26T13:20:05.776Z", "modified": "2021-12-10T17:56:45.258Z"}, {"entity": "publication", "iuid": "8b4f25b4edb743179b967a65d0b202dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b4f25b4edb743179b967a65d0b202dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b4f25b4edb743179b967a65d0b202dd"}}, "title": "Population-based study of multisystem inflammatory syndrome associated with COVID-19 found that 36% of children had persistent symptoms.", "authors": [{"family": "Kahn", "given": "Robin", "initials": "R", "orcid": "0000-0002-3167-1179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ac84bfddfbf425bad7a1484aa57414c.json"}}, {"family": "Berg", "given": "Stefan", "initials": "S"}, {"family": "Berntson", "given": "Lillemor", "initials": "L", "orcid": "0000-0003-3962-0453", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56b35f89d1b749b6bb447932384fe4d2.json"}}, {"family": "Berthold", "given": "Elisabet", "initials": "E"}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}, {"family": "B\u00e4ckstr\u00f6m", "given": "Fredrik", "initials": "F"}, {"family": "Compagno", "given": "Michele", "initials": "M"}, {"family": "Fasth", "given": "Anders", "initials": "A", "orcid": "0000-0002-0033-740X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f29cd19b2c7544bb83ce6879ffba2dc6.json"}}, {"family": "Lingman Framme", "given": "Jenny", "initials": "J"}, {"family": "Horne", "given": "AnnaCarin", "initials": "A"}, {"family": "H\u00e4tting", "given": "Josefin", "initials": "J"}, {"family": "Kr\u00f3l", "given": "Petra", "initials": "P"}, {"family": "Kukka", "given": "Antti J", "initials": "AJ"}, {"family": "Mossberg", "given": "Maria", "initials": "M"}, {"family": "M\u00e5nsson", "given": "Bengt", "initials": "B"}, {"family": "Nordenh\u00e4ll", "given": "Charlotta", "initials": "C"}, {"family": "Idring Nordstr\u00f6m", "given": "Selma", "initials": "S"}, {"family": "Khammari Nystr\u00f6m", "given": "Fatine", "initials": "F"}, {"family": "Palmblad", "given": "Karin", "initials": "K"}, {"family": "Rasti", "given": "Reza", "initials": "R"}, {"family": "Rudolph", "given": "Andr\u00e9", "initials": "A"}, {"family": "Rydenman", "given": "Karin", "initials": "K"}, {"family": "Sundberg", "given": "Erik", "initials": "E"}, {"family": "S\u00e4ve-S\u00f6derbergh", "given": "Eva", "initials": "E"}, {"family": "Altman", "given": "Maria", "initials": "M", "orcid": "0000-0001-8316-0154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9efee5220a52450fa208d78ef82a0e20.json"}}], "type": "journal article", "published": "2021-11-22", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253"}, "abstract": "Our aim was to describe the outcomes of multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19.\n\nThis national, population-based, longitudinal, multicentre study used Swedish data that were prospectively collected between 1 December 2020 and 31 May 2021. All patients met the World Health Organization criteria for MIS-C. The outcomes 2 and 8 weeks after diagnosis are presented, and follow-up protocols are suggested.\n\nWe identified 152 cases, and 133 (87%) participated. When followed up 2 weeks after MIS-C was diagnosed, 43% of the 119 patients had abnormal results, including complete blood cell counts, platelet counts, albumin levels, electrocardiograms and echocardiograms. After 8 weeks, 36% of 89 had an abnormal patient history, but clinical findings were uncommon. Echocardiogram results were abnormal in 5% of 67, and the most common complaint was fatigue. Older children and those who received intensive care were more likely to report symptoms and have abnormal cardiac results.\n\nMore than a third (36%) of the patients had persistent symptoms 8 weeks after MIS-C, and 5% had abnormal echocardiograms. Older age and higher levels of initial care appeared to be risk factors. Structured follow-up visits are important after MIS-C.", "doi": "10.1111/apa.16191", "pmid": "34806789", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T13:55:47.806Z", "modified": "2021-12-10T18:07:00.711Z"}, {"entity": "publication", "iuid": "c06d810ebd4b428ea3e8bf99e4f1872c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c06d810ebd4b428ea3e8bf99e4f1872c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c06d810ebd4b428ea3e8bf99e4f1872c"}}, "title": "Influenza outcomes in patients with inflammatory joint diseases and DMARDs: how do they compare to those of COVID-19?", "authors": [{"family": "Bower", "given": "Hannah", "initials": "H", "orcid": "0000-0002-2046-3833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac82ea2714c34d58a762b3cc168cbd4a.json"}}, {"family": "Frisell", "given": "Thomas", "initials": "T", "orcid": "0000-0002-5735-9626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e9d6be8c47b4d6eb80bd3d57a63172e.json"}}, {"family": "Di Giuseppe", "given": "Daniela", "initials": "D"}, {"family": "Delcoigne", "given": "B\u00e9n\u00e9dicte", "initials": "B"}, {"family": "Askling", "given": "Johan", "initials": "J", "orcid": "0000-0003-0433-0616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26359d7da52744208ca84bc65a5401cb.json"}}], "type": "journal article", "published": "2021-11-22", "journal": {"title": "Ann Rheum Dis", "issn": "1468-2060", "issn-l": null}, "abstract": "To estimate absolute and relative risks for seasonal influenza outcomes in patients with inflammatory joint diseases (IJDs) and disease-modifying antirheumatic drugs (DMARDs). To contextualise recent findings on corresponding COVID-19 risks.\n\nUsing Swedish nationwide registers for this cohort study, we followed 116 989 patients with IJD and matched population comparators across four influenza seasons (2015-2019). We quantified absolute risks of hospitalisation and death due to influenza, and compared IJD to comparators via Cox regression. We identified 71 556 patients with IJD on active treatment with conventional synthetic DMARDs and biological disease-modifying antirheumatic drugs (bDMARDs)/targeted synthetic disease-modifying antirheumatic drug (tsDMARDs) at the start of each influenza season, estimated risks for the same outcomes and compared these risks across DMARDs via Cox regression.\n\nPer season, average risks for hospitalisation listing influenza were 0.25% in IJD and 0.1% in the general population, corresponding to a crude HR of 2.38 (95% CI 2.21 to 2.56) that decreased to 1.44 (95% CI 1.33 to 1.56) following adjustments for comorbidities. For death listing influenza, the corresponding numbers were 0.015% and 0.006% (HR=2.63, 95% CI 1.93 to 3.58, and HR=1.46, 95% CI 1.07 to 2.01). Absolute risks for influenza outcomes were half (hospitalisation) and one-tenth (death) of those for COVID-19, but relative estimates comparing IJD to the general population were similar.\n\nIn absolute terms, COVID-19 in IJD outnumbers that of average seasonal influenza, but IJD entails a 50%-100% increase in risk for hospitalisation and death for both types of infections, which is largely dependent on associated comorbidities. Overall, bDMARDs/tsDMARDs do not seem to confer additional risk for hospitalisation or death related to seasonal influenza.", "doi": "10.1136/annrheumdis-2021-221461", "pmid": "34810197", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "annrheumdis-2021-221461"}, {"db": "pmc", "key": "PMC8610614"}], "notes": [], "created": "2021-11-26T13:53:59.516Z", "modified": "2021-12-10T18:04:20.305Z"}, {"entity": "publication", "iuid": "22fb1f7377424f5692811dbdffbf56d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/22fb1f7377424f5692811dbdffbf56d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/22fb1f7377424f5692811dbdffbf56d4"}}, "title": "Functional Antibodies Against SARS-CoV-2 Receptor Binding Domain Variants with Mutations N501Y or E484K in Human Milk from COVID-19-Vaccinated, -Recovered, and -Unvaccinated Women.", "authors": [{"family": "Demers-Mathieu", "given": "Veronique", "initials": "V", "orcid": "0000-0002-7937-6355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db7be05c02af4ba8a72768cd239f1f5e.json"}}, {"family": "Hakansson", "given": "Anders P", "initials": "AP"}, {"family": "Hall", "given": "Stephanie", "initials": "S"}, {"family": "Lavangnananda", "given": "Sirima", "initials": "S"}, {"family": "Fels", "given": "Shawn", "initials": "S"}, {"family": "Medo", "given": "Elena", "initials": "E"}], "type": "journal article", "published": "2021-11-22", "journal": {"title": "Breastfeed Med", "issn": "1556-8342", "issn-l": null}, "abstract": "New variants are evolving in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and receptor binding domain (RBD) mutations have been associated with a higher capacity to evade neutralizing antibodies (NAbs). We aimed at determining the impact of COVID-19 vaccine and infection on human milk antibody titers and activity against the RBD mutations from SARS-CoV-2 variants of concern. Background: Milk samples were collected from 19 COVID-19 vaccinated women, 10 women who had a positive COVID-19 PCR test, and 13 unvaccinated women. The titers and NAbs of secretory IgA (SIgA)/IgA, secretory IgM (IgM)/IgM, and IgG against SARS-CoV-2 RBD with mutations N501Y or E484K were measured by using ELISA and a surrogate virus neutralization assay. Materials and Methods: The titers of human milk IgG against N501Y were higher in the COVID-19 vaccine group than in the no-vaccine group but comparable with the COVID-19 PCR group. Other antibody titers did not differ between the three groups. The titers of SIgA/IgA were higher than those of SIgM/IgM and IgG in all three groups. The titers of SIgM/IgM and the inhibition of NAbs were higher against the mutation E484K than N501Y. Milk NAb did not differ between the three groups, but the inhibition of NAb against binding of the two mutant RBD proteins to their receptor was higher in the COVID-19 vaccine and PCR groups than in milk from prepandemic women. Results: COVID-19 vaccination and exposure of mothers to SARS-CoV-2 influenced the titers and NAbs in breast milk against the variants of concern.Conclusions:", "doi": "10.1089/bfm.2021.0232", "pmid": "34809492", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-11-26T13:54:16.969Z", "modified": "2021-12-10T18:05:02.477Z"}, {"entity": "publication", "iuid": "32657b84d5e64b6791e48042b4c0dbbb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/32657b84d5e64b6791e48042b4c0dbbb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/32657b84d5e64b6791e48042b4c0dbbb"}}, "title": "Drivers and social implications of Artificial Intelligence adoption in healthcare during the COVID-19 pandemic.", "authors": [{"family": "Frank", "given": "Darius-Aurel", "initials": "DA", "orcid": "0000-0002-1577-7352", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0a5cb4ef9514e01a08632ec84866fbf.json"}}, {"family": "Elb\u00e6k", "given": "Christian T", "initials": "CT", "orcid": "0000-0002-7039-4565", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a44f489ddccb4a208ec453424a471bfc.json"}}, {"family": "B\u00f8rsting", "given": "Caroline Kj\u00e6r", "initials": "CK"}, {"family": "Mitkidis", "given": "Panagiotis", "initials": "P"}, {"family": "Otterbring", "given": "Tobias", "initials": "T"}, {"family": "Borau", "given": "Sylvie", "initials": "S"}], "type": "journal article", "published": "2021-11-22", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "11", "pages": "e0259928", "issn-l": "1932-6203"}, "abstract": "The COVID-19 pandemic continues to impact people worldwide-steadily depleting scarce resources in healthcare. Medical Artificial Intelligence (AI) promises a much-needed relief but only if the technology gets adopted at scale. The present research investigates people's intention to adopt medical AI as well as the drivers of this adoption in a representative study of two European countries (Denmark and France, N = 1068) during the initial phase of the COVID-19 pandemic. Results reveal AI aversion; only 1 of 10 individuals choose medical AI over human physicians in a hypothetical triage-phase of COVID-19 pre-hospital entrance. Key predictors of medical AI adoption are people's trust in medical AI and, to a lesser extent, the trait of open-mindedness. More importantly, our results reveal that mistrust and perceived uniqueness neglect from human physicians, as well as a lack of social belonging significantly increase people's medical AI adoption. These results suggest that for medical AI to be widely adopted, people may need to express less confidence in human physicians and to even feel disconnected from humanity. We discuss the social implications of these findings and propose that successful medical AI adoption policy should focus on trust building measures-without eroding trust in human physicians.", "doi": "10.1371/journal.pone.0259928", "pmid": "34807907", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-20575"}, {"db": "pmc", "key": "PMC8608336"}], "notes": [], "created": "2021-11-26T13:55:05.093Z", "modified": "2021-12-10T18:06:08.493Z"}, {"entity": "publication", "iuid": "7b2ef4c42a3d47fc89c04b015438c234", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b2ef4c42a3d47fc89c04b015438c234.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b2ef4c42a3d47fc89c04b015438c234"}}, "title": "Accessible data curation and analytics for international-scale citizen science datasets.", "authors": [{"family": "Murray", "given": "Benjamin", "initials": "B", "orcid": "0000-0002-2413-923X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebec738df0224bf4874fd6c08fd23fae.json"}}, {"family": "Kerfoot", "given": "Eric", "initials": "E"}, {"family": "Chen", "given": "Liyuan", "initials": "L"}, {"family": "Deng", "given": "Jie", "initials": "J"}, {"family": "Graham", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-4170-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f5f4e19812a46ed9e873732ec25e28d.json"}}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Molteni", "given": "Erika", "initials": "E", "orcid": "0000-0001-7773-8140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9aed1fbe444b48d4bfacb12050953c8e.json"}}, {"family": "Canas", "given": "Liane S", "initials": "LS", "orcid": "0000-0002-2553-1284", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c8d4abc0be246a1b77bf183be19efb6.json"}}, {"family": "Antonelli", "given": "Michela", "initials": "M"}, {"family": "Klaser", "given": "Kerstin", "initials": "K"}, {"family": "Visconti", "given": "Alessia", "initials": "A", "orcid": "0000-0003-4144-2019", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ce0429ccf674827aedbb8d05a53145c.json"}}, {"family": "Hammers", "given": "Alexander", "initials": "A", "orcid": "0000-0001-9530-4848", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aade93dbff2d4187a039a8e50027ed9c.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-7284-6767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeefbf47fd384d5390109fe1a903bd18.json"}}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Davies", "given": "Richard", "initials": "R", "orcid": "0000-0003-2050-3994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b82cc92615f462d9af0153a6fb94fde.json"}}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Modat", "given": "Marc", "initials": "M"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}], "type": "journal article", "published": "2021-11-22", "journal": {"title": "Sci Data", "issn": "2052-4463", "issn-l": null, "volume": "8", "issue": "1", "pages": "297"}, "abstract": "The Covid Symptom Study, a smartphone-based surveillance study on COVID-19 symptoms in the population, is an exemplar of big data citizen science. As of May 23rd, 2021, over 5 million participants have collectively logged over 360 million self-assessment reports since its introduction in March 2020. The success of the Covid Symptom Study creates significant technical challenges around effective data curation. The primary issue is scale. The size of the dataset means that it can no longer be readily processed using standard Python-based data analytics software such as Pandas on commodity hardware. Alternative technologies exist but carry a higher technical complexity and are less accessible to many researchers. We present ExeTera, a Python-based open source software package designed to provide Pandas-like data analytics on datasets that approach terabyte scales. We present its design and capabilities, and show how it is a critical component of a data curation pipeline that enables reproducible research across an international research group for the Covid Symptom Study.", "doi": "10.1038/s41597-021-01071-x", "pmid": "34811392", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41597-021-01071-x"}, {"db": "pmc", "key": "PMC8608807"}, {"db": "URL", "key": "https://github.com/KCL-BMEIS/ExeTera", "description": "https://github.com/KCL-BMEIS/ExeTera"}, {"db": "URL", "key": "https://github.com/KCL-BMEIS/ExeTera/wiki", "description": "https://github.com/KCL-BMEIS/ExeTera/wiki"}], "notes": [], "created": "2021-11-26T13:50:02.786Z", "modified": "2021-12-10T18:03:32.696Z"}, {"entity": "publication", "iuid": "15305e51a3c54f05ae698e9df0084837", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15305e51a3c54f05ae698e9df0084837.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15305e51a3c54f05ae698e9df0084837"}}, "title": "Defining the impact of SARS-COV-2 on delivery of CAR T-cell therapy in Europe: a retrospective survey from the CTIWP of the EBMT.", "authors": [{"family": "Ghorashian", "given": "Sara", "initials": "S", "orcid": "0000-0002-1555-2946", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fec721406a44d8983774c214511454d.json"}}, {"family": "Malard", "given": "Florent", "initials": "F"}, {"family": "Y\u00fcksel", "given": "Meltem Kurt", "initials": "MK"}, {"family": "Mauff", "given": "Katya", "initials": "K"}, {"family": "Hoogenboom", "given": "Jorinde D", "initials": "JD"}, {"family": "Urbano-Ispizua", "given": "Alvaro", "initials": "A"}, {"family": "Kuball", "given": "J\u00fcrgen", "initials": "J", "orcid": "0000-0002-3914-7806", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93b68b37f90949f681e03905510def84.json"}}, {"family": "de la Camara", "given": "Rafael", "initials": "R", "orcid": "0000-0002-8189-5779", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/868bc0284ac640a1bf215e7d7cc86da3.json"}}, {"family": "Ljungman", "given": "Per", "initials": "P", "orcid": "0000-0002-8281-3245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4546eb504184683ab712eee858ea9cb.json"}}, {"family": "Ruggeri", "given": "Annalisa", "initials": "A"}, {"family": "Chabannon", "given": "Christian", "initials": "C", "orcid": "0000-0002-3755-4889", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6383ab718ee423da23a515b971751bc.json"}}], "type": "letter", "published": "2021-11-20", "journal": {"title": "Bone Marrow Transplant", "issn": "1476-5365", "issn-l": "0268-3369"}, "abstract": null, "doi": "10.1038/s41409-021-01483-8", "pmid": "34802048", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41409-021-01483-8"}, {"db": "pmc", "key": "PMC8605455"}], "notes": [], "created": "2021-11-26T13:56:54.008Z", "modified": "2021-12-10T17:55:26.855Z"}, {"entity": "publication", "iuid": "21d56c12669e4c4fa3c217c0af208c34", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/21d56c12669e4c4fa3c217c0af208c34.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/21d56c12669e4c4fa3c217c0af208c34"}}, "title": "Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials.", "authors": [{"family": "Axfors", "given": "Cathrine", "initials": "C"}, {"family": "Janiaud", "given": "Perrine", "initials": "P"}, {"family": "Schmitt", "given": "Andreas M", "initials": "AM"}, {"family": "Van't Hooft", "given": "Janneke", "initials": "J"}, {"family": 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"initials": "Y"}, {"family": "Webb", "given": "Steve A", "initials": "SA"}, {"family": "Wiese", "given": "Lothar", "initials": "L"}, {"family": "Wik\u00e9n", "given": "Christian", "initials": "C"}, {"family": "Wood", "given": "Erica M", "initials": "EM"}, {"family": "Yusubalieva", "given": "Gaukhar M", "initials": "GM"}, {"family": "Zacharowski", "given": "Kai", "initials": "K"}, {"family": "Zarychanski", "given": "Ryan", "initials": "R"}, {"family": "Khanna", "given": "Nina", "initials": "N"}, {"family": "Moher", "given": "David", "initials": "D"}, {"family": "Goodman", "given": "Steven N", "initials": "SN"}, {"family": "Ioannidis", "given": "John P A", "initials": "JPA"}, {"family": "Hemkens", "given": "Lars G", "initials": "LG"}], "type": "journal article", "published": "2021-11-20", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "volume": "21", "issue": "1", "pages": "1170", "issn-l": null}, "abstract": "Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment and all-cause mortality in patients with COVID-19, using data from all available randomized clinical trials, including unpublished and ongoing trials (Open Science Framework, https://doi.org/10.17605/OSF.IO/GEHFX ).\n\nIn this collaborative systematic review and meta-analysis, clinical trial registries (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform), the Cochrane COVID-19 register, the LOVE database, and PubMed were searched until April 8, 2021. Investigators of trials registered by March 1, 2021, without published results were contacted via email. Eligible were ongoing, discontinued and completed randomized clinical trials that compared convalescent plasma with placebo or no treatment in COVID-19 patients, regardless of setting or treatment schedule. Aggregated mortality data were extracted from publications or provided by investigators of unpublished trials and combined using the Hartung-Knapp-Sidik-Jonkman random effects model. We investigated the contribution of unpublished trials to the overall evidence.\n\nA total of 16,477 patients were included in 33 trials (20 unpublished with 3190 patients, 13 published with 13,287 patients). 32 trials enrolled only hospitalized patients (including 3 with only intensive care unit patients). Risk of bias was low for 29/33 trials. Of 8495 patients who received convalescent plasma, 1997 died (23%), and of 7982 control patients, 1952 died (24%). The combined risk ratio for all-cause mortality was 0.97 (95% confidence interval: 0.92; 1.02) with between-study heterogeneity not beyond chance (I2 = 0%). The RECOVERY trial had 69.8% and the unpublished evidence 25.3% of the weight in the meta-analysis.\n\nConvalescent plasma treatment of patients with COVID-19 did not reduce all-cause mortality. These results provide strong evidence that convalescent plasma treatment for patients with COVID-19 should not be used outside of randomized trials. Evidence synthesis from collaborations among trial investigators can inform both evidence generation and evidence application in patient care.", "doi": "10.1186/s12879-021-06829-7", "pmid": "34800996", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12879-021-06829-7"}, {"db": "pmc", "key": "PMC8605464"}, {"db": "URL", "key": "Open Science Framework https://osf.io/gehfx/", "description": "https://osf.io/gehfx/"}], "notes": [], "created": "2021-11-26T13:57:19.972Z", "modified": "2021-11-26T13:58:22.778Z"}, {"entity": "publication", "iuid": "ba87bfd694b0454f8117a4874c4dd903", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ba87bfd694b0454f8117a4874c4dd903.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ba87bfd694b0454f8117a4874c4dd903"}}, "title": "Parturient with Covid-19 and need for intensive care: an observational study in the Nordic countries.", "authors": [{"family": "Karlsson", "given": "Ove", "initials": "O"}, {"family": "Hein", "given": "Anette", "initials": "A"}, {"family": "Eriksson", "given": "Susanne Ledin", "initials": "SL"}, {"family": "Pettersson", "given": "Karin", "initials": "K"}], "type": "letter", "published": "2021-11-19", "journal": {"title": "Am J Obstet Gynecol MFM", "issn": "2589-9333", "pages": "100532", "issn-l": null}, "abstract": null, "doi": "10.1016/j.ajogmf.2021.100532", "pmid": "34808399", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2589-9333(21)00228-7"}, {"db": "pmc", "key": "PMC8603919"}], "notes": [], "created": "2021-11-26T13:54:43.704Z", "modified": "2021-12-10T18:05:37.974Z"}, {"entity": "publication", "iuid": "2204d45084694f919be24fa50620fda0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2204d45084694f919be24fa50620fda0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2204d45084694f919be24fa50620fda0"}}, "title": "Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities.", "authors": [{"family": "Kruse", "given": "Thomas", "initials": "T"}, {"family": "Benz", "given": "Caroline", "initials": "C", "orcid": "0000-0002-5166-3598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13332514bfe7460db4a0f134718aa211.json"}}, {"family": "Garvanska", "given": "Dimitriya H", "initials": "DH"}, {"family": "Lindqvist", "given": "Richard", "initials": "R"}, {"family": "Mihalic", "given": "Filip", "initials": "F"}, {"family": "Coscia", "given": "Fabian", "initials": "F"}, {"family": "Inturi", "given": "Raviteja", "initials": "R", "orcid": "0000-0003-1344-3962", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6636c43ae584420fbe80f82393225824.json"}}, {"family": "Sayadi", "given": "Ahmed", "initials": "A"}, {"family": "Simonetti", "given": "Leandro", "initials": "L", "orcid": "0000-0003-1283-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9ef81e96c104878a6ccea620fc95400.json"}}, {"family": "Nilsson", "given": "Emma", "initials": "E"}, {"family": "Ali", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-8858-6776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0515e4fd072741b0a01456320bbf73de.json"}}, {"family": "Kliche", "given": "Johanna", "initials": "J"}, {"family": "Moliner Morro", "given": "Ainhoa", "initials": "A"}, {"family": "Mund", "given": "Andreas", "initials": "A", "orcid": "0000-0002-7843-5341", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e533a4bd6914e68be49773ccf0db693.json"}}, {"family": "Andersson", "given": "Eva", "initials": "E"}, {"family": "McInerney", "given": "Gerald", "initials": "G", "orcid": "0000-0003-2257-7241", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7770437d845444a8a07865bf5b62fab0.json"}}, {"family": "Mann", "given": "Matthias", "initials": "M"}, {"family": "Jemth", "given": "Per", "initials": "P", "orcid": "0000-0003-1516-7228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c5fe566cf5f44df9c98bb2b1d7078ba.json"}}, {"family": "Davey", "given": "Norman E", "initials": "NE"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK", "orcid": "0000-0001-6553-0940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9024ab251cf44bffbf3229ec909343af.json"}}, {"family": "Nilsson", "given": "Jakob", "initials": "J", "orcid": "0000-0003-4100-1125", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f2ecaef653e54c63b20d88574c03b8b2.json"}}, {"family": "Ivarsson", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-7081-3846", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b3cf0504a1b476f906c4b3e22b05d5a.json"}}], "type": "journal article", "published": "2021-11-19", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "6761"}, "abstract": "Viral proteins make extensive use of short peptide interaction motifs to hijack cellular host factors. However, most current large-scale methods do not identify this important class of protein-protein interactions. Uncovering peptide mediated interactions provides both a molecular understanding of viral interactions with their host and the foundation for developing novel antiviral reagents. Here we describe a viral peptide discovery approach covering 23 coronavirus strains that provides high resolution information on direct virus-host interactions. We identify 269 peptide-based interactions for 18 coronaviruses including a specific interaction between the human G3BP1/2 proteins and an \u03a6xFG peptide motif in the SARS-CoV-2 nucleocapsid (N) protein. This interaction supports viral replication and through its \u03a6xFG motif N rewires the G3BP1/2 interactome to disrupt stress granules. A peptide-based inhibitor disrupting the G3BP1/2-N interaction dampened SARS-CoV-2 infection showing that our results can be directly translated into novel specific antiviral reagents.", "doi": "10.1038/s41467-021-26498-z", "pmid": "34799561", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null, "Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC8605023"}, {"db": "pii", "key": "10.1038/s41467-021-26498-z"}], "notes": [], "created": "2021-11-26T14:03:59.548Z", "modified": "2023-06-19T15:06:00.564Z"}, {"entity": "publication", "iuid": "57ffc67fec3d47b49ba7cb301f827abc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/57ffc67fec3d47b49ba7cb301f827abc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/57ffc67fec3d47b49ba7cb301f827abc"}}, "title": "High sleep fragmentation parallels poor subjective sleep quality during the third wave of the Covid-19 pandemic: An actigraphic study.", "authors": [{"family": "Conte", "given": "Francesca", "initials": "F", "orcid": "0000-0002-5429-5831", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25298eaae41b49a58d9103796937f69e.json"}}, {"family": "De Rosa", "given": "Oreste", "initials": "O"}, {"family": "Rescott", "given": "Marissa Lynn", "initials": "ML"}, {"family": "Arabia", "given": "Teresa Pia", "initials": "TP"}, {"family": "D'Onofrio", "given": "Paolo", "initials": "P"}, {"family": "Lustro", "given": "Alessio", "initials": "A"}, {"family": "Malloggi", "given": "Serena", "initials": "S", "orcid": "0000-0003-1813-8916", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb2487e0d35c41f8b75fba2f7a6441d2.json"}}, {"family": "Molinaro", "given": "Danila", "initials": "D"}, {"family": "Spagnoli", "given": "Paola", "initials": "P"}, {"family": "Giganti", "given": "Fiorenza", "initials": "F", "orcid": "0000-0002-9362-5258", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/99e3ab3bd59b425ab8b21b806500774e.json"}}, {"family": "Barbato", "given": "Giuseppe", "initials": "G", "orcid": "0000-0001-6523-5327", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47264cf640f74008afde9622672a452d.json"}}, {"family": "Ficca", "given": "Gianluca", "initials": "G", "orcid": "0000-0001-9519-4351", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c00e9acb5674411ac84ab79c36b8b22.json"}}], "type": "journal article", "published": "2021-11-19", "journal": {"title": "J Sleep Res", "issn": "1365-2869", "pages": "e13519", "issn-l": "0962-1105"}, "abstract": "Studies on sleep during the Covid-19 pandemic have mostly been conducted during the first wave of contagion (spring 2020). To follow up on two Italian studies addressing subjective sleep features during the second wave (autumn 2020), here we assess sleep during the third wave (spring 2021) in a sample of healthy adults from Campania (Southern Italy). Actigraphic data (on 2 nights) and the Pittsburgh Sleep Quality Index were collected from 82 participants (40 F, mean age: 32.5 \u00b1 11.5 years) from 11 March to 18 April 2021, when Campania was classified as a \"red zone\", i.e. it was subjected to strict restrictions, only slightly looser than those characterizing the first national lockdown (spring 2020). Although objective sleep duration and architecture appeared in the normal range, the presence of disrupted sleep was indexed by a relevant degree of sleep fragmentation (number of awakenings \u2265 1 min: 12.7 \u00b1 6.12; number of awakenings \u2265 5 min: 3.04 \u00b1 1.52), paralleled by poor subjective sleep quality (Pittsburgh Sleep Quality Index global score: 5.77 \u00b1 2.58). These data suggest that the relevant subjective sleep impairments reported during the first wave could have relied on subtle sleep disruptions that were undetected by the few objective sleep studies from the same period. Taken together with sleep data on previous phases of the pandemic, our findings show that the detrimental effects on sleep determined by the initial pandemic outbreak have not abated across the subsequent waves of contagion, and highlight the need for interventions addressing sleep health in global emergencies.", "doi": "10.1111/jsr.13519", "pmid": "34797004", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T14:05:35.775Z", "modified": "2021-11-26T14:05:35.965Z"}, {"entity": "publication", "iuid": "42a5b1f5ed414ca89ebfa2f8135b2fdf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/42a5b1f5ed414ca89ebfa2f8135b2fdf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/42a5b1f5ed414ca89ebfa2f8135b2fdf"}}, "title": "Fear of COVID-19 and Trust in the Healthcare System Mediates the Association between Individual's Risk Perception and Preventive COVID-19 Behaviours among Iranians.", "authors": [{"family": "Alijanzadeh", "given": "Mehran", "initials": "M"}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK", "orcid": "0000-0003-0530-8138", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d442447b551649d8a5372c6bf0075c91.json"}}, {"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Mahmoudi", "given": "Narges", "initials": "N"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Liu", "given": "Hsien-Kuan", "initials": "HK", "orcid": "0000-0003-0176-1381", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee8322e92e0e4d9cb5739b6fa1ac9d7f.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-11-19", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "22", "issn-l": null}, "abstract": "Problems caused by the novel coronavirus disease-2019 (COVID-19) and its mutations have brought challenges in pandemic control for all countries worldwide. The present study examines the mediating roles of fear of COVID-19 and trust in the healthcare system in the association between individual's risk perception and performing preventive COVID-19 behaviours among Iranians. A cross-sectional study design was used to collect data from 3652 residents of Qazvin province in Iran from 3 February to 15 April 2021 using a multistage stratified cluster sampling method. Participants responded to an online questionnaire concerning their fear of COVID-19, risk perception, trust in the healthcare system, and preventive COVID-19 behaviours. Small to medium positive interrelationships were observed between the variables of the study. Fear of COVID-19, trust in the healthcare system or both (fear of COVID-19 and trust in the healthcare system) mediated the association between an individual's risk perception and performing preventive COVID-19 behaviours. The study demonstrated there are at least four ways through which an individual's risk perception can influence preventive COVID-19 behaviours. Therefore, clinicians, health communicators, and researchers may capitalize on these findings to enhance preventive COVID-19 behaviours to help mitigate the spread of COVID-19 infection.", "doi": "10.3390/ijerph182212146", "pmid": "34831900", "labels": {"Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182212146"}, {"db": "pmc", "key": "PMC8621944"}], "notes": [], "created": "2021-12-18T18:16:01.936Z", "modified": "2021-12-18T18:16:02.033Z"}, {"entity": "publication", "iuid": "f645e0019835455a984c862319a6db39", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f645e0019835455a984c862319a6db39.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f645e0019835455a984c862319a6db39"}}, "title": "Clinical and hospitalisation predictors of COVID-19 in the first month of the pandemic, Portugal.", "authors": [{"family": "Perez Duque", "given": "Mariana", "initials": "M", "orcid": "0000-0001-9999-8402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6f20ad39f5c74255b07b64d6dc93f17c.json"}}, {"family": "Saad", "given": "Neil J", "initials": "NJ"}, {"family": "Lucaccioni", "given": "H\u00e9lo\u00efse", "initials": "H"}, {"family": "Costa", "given": "Cristina", "initials": "C"}, {"family": "McMahon", "given": "Geroid", "initials": "G"}, {"family": "Machado", "given": "Firmino", "initials": "F"}, {"family": "Balasegaram", "given": "Sooria", "initials": "S"}, {"family": "S\u00e1 Machado", "given": "Rita", "initials": "R"}], "type": "journal article", "published": "2021-11-19", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "11", "pages": "e0260249", "issn-l": "1932-6203"}, "abstract": "COVID-19 mainly presents as a respiratory disease with flu-like symptoms, however, recent findings suggest that non-respiratory symptoms can occur early in the infection and cluster together in different groups in different regions. We collected surveillance data among COVID-19 suspected cases tested in mainland Portugal during the first wave of the pandemic, March-April 2020. A multivariable logistic-regression analysis was performed to ascertain the effects of age, sex, prior medical condition and symptoms on the likelihood of testing positive and hospitalisation. Of 25,926 COVID-19 suspected cases included in this study, 5,298 (20%) tested positive. Symptoms were grouped into ten clusters, of which two main ones: one with cough and fever and another with the remainder. There was a higher odds of a positive test with increasing age, myalgia and headache. The odds of being hospitalised increased with age, presence of fever, dyspnoea, or having a prior medical condition although these results varied by region. Presence of cough and other respiratory symptoms did not predict COVID-19 compared to non-COVID respiratory disease patients in any region. Dyspnoea was a strong determinant of hospitalisation, as well as fever and the presence of a prior medical condition, whereas these results varied by region.", "doi": "10.1371/journal.pone.0260249", "pmid": "34797879", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-13990"}, {"db": "pmc", "key": "PMC8604361"}], "notes": [], "created": "2021-11-26T14:05:16.418Z", "modified": "2021-11-26T14:05:16.473Z"}, {"entity": "publication", "iuid": "75fa1f2465c24fa18ebf10faee384bc8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/75fa1f2465c24fa18ebf10faee384bc8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/75fa1f2465c24fa18ebf10faee384bc8"}}, "title": "COVID-19 Testing in Sweden During 2020-Split Responsibilities and Multi-Level Challenges.", "authors": [{"family": "Fredriksson", "given": "Mio", "initials": "M"}, {"family": "Hallberg", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-11-19", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "754861", "issn-l": "2296-2565"}, "abstract": "Sweden's use of soft response measures early in the COVID-19 pandemic received a good deal of international attention. Within Sweden, one of the most debated aspects of the pandemic response has been COVID-19 testing and the time it took to increase testing capacity. In this article, the development of and the debate surrounding COVID-19 testing in Sweden during 2020 is described in detail, with a particular focus on the coordination between national and regional actors in the decentralised healthcare system. A qualitative case study was carried out based on qualitative document analysis with a chronological presentation. To understand COVID-19 testing in Sweden, two aspects of its public administration model emerged as particularly important: (i) the large and independent government agencies and (ii) self-governing regions and municipalities. In addition, the responsibility principle in Swedish crisis management was crucial. Overall, the results show that mass testing was a new area for coordination and involved a number of national and regional actors with partly different views on their respective roles, responsibilities and interpretations of the laws and regulations. The description shows the ambiguities in the purpose of testing and the shortcomings in communication and cooperation during the first half of 2020, but after that an increasing consistency among the crucial actors. During the first half of 2020, testing capacity in Sweden was limited and reserved to protect the most vulnerable in society. Because mass testing for viruses is not normally carried out by the 21 self-governing regions responsible for healthcare and communicable disease prevention, and the Public Health Agency of Sweden stated that there was no medical reason to test members of the public falling ill with COVID-like symptoms, the responsibility for mass testing fell through the cracks during the first few months of the pandemic. This article thus illustrates problems associated with multi-level governance in healthcare during a crisis and illustrates the discrepancy between the health service's focus on the individual and the public health-oriented work carried out within communicable disease control.", "doi": "10.3389/fpubh.2021.754861", "pmid": "34869171", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC8639858"}], "notes": [], "created": "2021-12-12T07:09:35.537Z", "modified": "2023-07-13T11:28:19.389Z"}, {"entity": "publication", "iuid": "0c76fbcbdeaf4122ba8d9d2e761978e6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c76fbcbdeaf4122ba8d9d2e761978e6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c76fbcbdeaf4122ba8d9d2e761978e6"}}, "title": "'Who will do it if I don't?' Nurse anaesthetists' experiences of working in the intensive care unit during the COVID-19 pandemic.", "authors": [{"family": "Hallgren", "given": "Jenny", "initials": "J"}, {"family": "Larsson", "given": "Margaretha", "initials": "M"}, {"family": "Kjell\u00e9n", "given": "Malin", "initials": "M"}, {"family": "Lagerroth", "given": "David", "initials": "D"}, {"family": "B\u00e4ckstr\u00f6m", "given": "Caroline", "initials": "C"}], "type": "journal article", "published": "2021-11-19", "journal": {"title": "Aust Crit Care", "issn": "1036-7314", "issn-l": null}, "abstract": "During the COVID-19 pandemic, the workload on the intensive care unit (ICU) increased nationally in Sweden as well as globally. Certified registered nurse anaesthetists (CRNAs) in Sweden were transferred at short notice to work with seriously ill patients with COVID-19 in the ICU, which is not part of the CRNAs' specialist area. However, limited research has shed light on healthcare professionals' experiences of the pandemic.\n\nThis study illuminates CRNAs' experiences of working in the ICU during the COVID-19 pandemic.\n\nThis study used a qualitative method with an inductive approach to interview nurse anaesthetists who worked in the ICU during the COVID-19 pandemic.\n\nThe participants experienced ambivalent feelings towards their work in the ICU. They also lacked information, which created feelings of uncertainty and resulted in expectations that did not correspond to the reality. They described that owing to an inadequate introduction, they could only provide \"sufficient\" care, which in many cases caused ethical stress. Not being able to get to know their new colleagues well enough to create effective cooperation created frustration. Even though the participants experienced the work in the ICU as demanding and challenging, overall, they enjoyed their time in the ICU and were treated well by their colleagues.\n\nAlthough CRNAs cannot replace intensive care nurses, they are a useful resource in the ICU in the care of patients with COVID-19. Healthcare workers who are allocated from their ordinary units to the ICU need adequate information and support from their work managers to be able to provide the best possible care and to stay healthy themselves.", "doi": "10.1016/j.aucc.2021.11.003", "pmid": "34955333", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1036-7314(21)00171-5"}, {"db": "pmc", "key": "PMC8602969"}], "notes": [], "created": "2022-01-04T15:25:03.308Z", "modified": "2022-01-04T15:25:03.321Z"}, {"entity": "publication", "iuid": "eb87609ca02340e78b47e4023949bbcd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb87609ca02340e78b47e4023949bbcd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb87609ca02340e78b47e4023949bbcd"}}, "title": "The extent of neuroradiological findings in COVID-19 shows correlation with blood biomarkers, Glasgow coma scale score and days in intensive care.", "authors": [{"family": "F\u00e4llmar", "given": "David", "initials": "D"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ"}, {"family": "Jackmann", "given": "Sven", "initials": "S"}, {"family": "Pavel", "given": "Radu", "initials": "R"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Westman", "given": "Gabriel", "initials": "G"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Virhammar", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2021-11-18", "journal": {"title": "J Neuroradiol", "issn": "0150-9861", "issn-l": null}, "abstract": "A wide range of neuroradiological findings has been reported in patients with coronavirus disease 2019 (COVID-19), ranging from subcortical white matter changes to infarcts, haemorrhages and focal contrast media enhancement. These have been descriptively but inconsistently reported and correlations with clinical findings and biomarkers have been difficult to extract from the literature. The purpose of this study was to quantify the extents of neuroradiological findings in a cohort of patients with COVID-19 and neurological symptoms, and to investigate correlations with clinical findings, duration of intensive care and biomarkers in blood.\n\nPatients with positive SARS-CoV-2 and at least one new-onset neurological symptom were included from April until July 2020. Nineteen patients were examined regarding clinical symptoms, biomarkers in blood and MRI of the brain. In order to quantify the MRI findings, a semi-quantitative neuroradiological severity scale was constructed a priori, and applied to the MR images by two specialists in neuroradiology.\n\nThe score from the severity scale correlated significantly with blood biomarkers of CNS injury (glial fibrillary acidic protein, total-tau, ubiquitin carboxyl-terminal hydrolase L1) and inflammation (C-reactive protein), Glasgow Coma Scale score, and the number of days spent in intensive care. The underlying radiological assessments had inter-rater agreements of 90.5%/86% (for assessments with 2/3 alternatives). Total intraclass correlation was 0.80. Previously reported neuroradiological findings in COVID-19 have been diverse and heterogenous. In this study, the extent of findings in MRI examination of the brain, quantified using a structured report, shows correlation with relevant biomarkers.", "doi": "10.1016/j.neurad.2021.11.003", "pmid": "34800562", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0150-9861(21)00167-X"}, {"db": "pmc", "key": "PMC8599173"}], "notes": [], "created": "2021-11-26T14:02:06.243Z", "modified": "2021-12-10T17:54:55.138Z"}, {"entity": "publication", "iuid": "61d8c768c9ee42fb8ec88ce2408194e9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61d8c768c9ee42fb8ec88ce2408194e9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61d8c768c9ee42fb8ec88ce2408194e9"}}, "title": "Red blood cell blood group A antigen level affects the ability of heparin and PfEMP1 antibodies to disrupt Plasmodium falciparum rosettes.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P", "orcid": "0000-0003-3153-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd6af5accfc84ff9a81983a5ab6683aa.json"}}, {"family": "Sirel", "given": "Madle", "initials": "M"}, {"family": "Moll", "given": "Kirsten", "initials": "K"}, {"family": "Kiwuwa", "given": "Mpungu Steven", "initials": "MS"}, {"family": "H\u00f6glund", "given": "Petter", "initials": "P"}, {"family": "Ribacke", "given": "Ulf", "initials": "U"}, {"family": "Wahlgren", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2021-11-18", "journal": {"title": "Malar J", "issn": "1475-2875", "volume": "20", "issue": "1", "pages": "441", "issn-l": null}, "abstract": "The histo-blood group ABO system has been associated with adverse outcomes in COVID-19, thromboembolic diseases and Plasmodium falciparum malaria. An integral part of the severe malaria pathogenesis is rosetting, the adherence of parasite infected red blood cells (RBCs) to uninfected RBCs. Rosetting is influenced by the host's ABO blood group (Bg) and rosettes formed in BgA have previously been shown to be more resilient to disruption by heparin and shield the parasite derived surface antigens from antibodies. However, data on rosetting in weak BgA subgroups is scarce and based on investigations of relatively few donors.\n\nAn improved high-throughput flow cytometric assay was employed to investigate rosetting characteristics in an extensive panel of RBC donor samples of all four major ABO Bgs, as well as low BgA expressing samples.\n\nAll non-O Bgs shield the parasite surface antigens from strain-specific antibodies towards P. falciparum erythrocyte membrane protein 1 (PfEMP1). A positive correlation between A-antigen levels on RBCs and rosette tightness was observed, protecting the rosettes from heparin- and antibody-mediated disruption.\n\nThese results provide new insights into how the ABO Bg system affects the disease outcome and cautions against interpreting the results from the heterogeneous BgA phenotype as a single group in epidemiological and experimental studies.", "doi": "10.1186/s12936-021-03975-w", "pmid": "34794445", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12936-021-03975-w"}, {"db": "pmc", "key": "PMC8600353"}], "notes": [], "created": "2021-11-26T14:10:07.743Z", "modified": "2021-11-26T14:10:07.797Z"}, {"entity": "publication", "iuid": "701bbb9615b6499f804cebf6ab23736f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/701bbb9615b6499f804cebf6ab23736f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/701bbb9615b6499f804cebf6ab23736f"}}, "title": "Are sex disparities in COVID-19 a predictable outcome of failing men's health provision?", "authors": [{"family": "Tharakan", "given": "Tharu", "initials": "T"}, {"family": "Khoo", "given": "Christopher C", "initials": "CC", "orcid": "0000-0002-1706-2457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4577a71a676e449caa7c8f224b4da83f.json"}}, {"family": "Giwercman", "given": "Aleksander", "initials": "A"}, {"family": "Jayasena", "given": "Channa N", "initials": "CN", "orcid": "0000-0002-2578-8223", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b94255faecdd403a951cd4d854c1fb7d.json"}}, {"family": "Sofikitis", "given": "Nikolaos", "initials": "N", "orcid": "0000-0003-1528-4029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/878fcbbf78bf4f98bc7622484e44415d.json"}}, {"family": "Salonia", "given": "Andrea", "initials": "A", "orcid": "0000-0002-0595-7165", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/940b454070ba44e8ad349d3c8f6c06c3.json"}}, {"family": "Minhas", "given": "Suks", "initials": "S"}], "type": "journal article", "published": "2021-11-18", "journal": {"title": "Nat Rev Urol", "issn": "1759-4820", "issn-l": null}, "abstract": "The COVID-19 pandemic, caused by the SARS-CoV-2 coronavirus, has taken a catastrophic toll on society, health-care systems and the economy. Notably, COVID-19 has been shown to be associated with a higher mortality rate in men than in women. This disparity is likely to be a consequence of a failure to invest in men's health, as it has also been established that men have a lower life expectancy and poorer outcomes from non-communicable diseases than women. A variety of biological, social and economic factors have contributed to the sex disparities in mortality from COVID-19. A streamlined men's health programme - with the urologist as the gatekeeper of men's health - is needed to help prevent future tragedies of this nature.", "doi": "10.1038/s41585-021-00535-4", "pmid": "34795426", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41585-021-00535-4"}, {"db": "pmc", "key": "PMC8600906"}], "notes": [], "created": "2021-11-26T14:08:51.860Z", "modified": "2021-11-26T14:08:52.023Z"}, {"entity": "publication", "iuid": "d60de72901f74a45895fc2c45e98c87b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d60de72901f74a45895fc2c45e98c87b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d60de72901f74a45895fc2c45e98c87b"}}, "title": "Analyzing the Stressors for Frontline Soldiers Fighting Against Coronavirus Disease 2019 Pandemic.", "authors": [{"family": "Shaukat", "given": "Muhammad Zeeshan", "initials": "MZ"}, {"family": "Scholz", "given": "Miklas", "initials": "M"}, {"family": "Qazi", "given": "Tehmina Fiaz", "initials": "TF"}, {"family": "Niazi", "given": "Abdul Aziz Khan", "initials": "AAK"}, {"family": "Basit", "given": "Abdul", "initials": "A"}, {"family": "Mahmood", "given": "Asif", "initials": "A"}], "type": "journal article", "published": "2021-11-18", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "751882", "issn-l": "1664-1078"}, "abstract": "This study aimed to analyze stressors to which medical staff is vulnerable due to the coronavirus disease 2019 (COVID-19) pandemic. It also imposes a hierarchy on complex relations among stressors for excavating underlying structure and builds a model of interrelationships contrasting reality. The design of this study comprises a literature survey, data collection from primary sources, and analysis. Stressors have been explored from within current published/unpublished literature and validated by experts through approval vote. Data were collected from the focus group (panel of experts), and interpretive structural modeling (ISM) was used as the research methodology. Findings of ISM are avowed through \"cross-impact matrix multiplication applied to classification\" (MICMAC) analysis. As a result of the literature survey, a list of stressors was generated, and a total of 19 stressors qualified as representative of the phenomenon. The results of ISM show that two stressors (i.e., \"unavailability of proper personal protective equipment (PPE)\" and \"lack of proper communication\") emerged as the most critical stressors since they occupy the bottom of the model, whereas, four stressors (i.e., \"anxious about isolation/quarantine,\" \"subject to violent crimes,\" \"feeling frustrated and powerless,\" and \"exhausting shifts/hours without clear end\") are relatively less critical since they occupy the top of the model. The rest of the stressors occupy the middle of the model and therefore, have moderate-severe effects on frontline soldiers. The results of MICMAC show that the stressor \"subject to violent crimes\" is classified in the dependent cluster and the remaining fall in the linkage cluster but no stressor falls in independent and autonomous. Overall results indicate that all stressors are relevant to the phenomenon under this study, but they are currently not settled. This study is invaluable for policymakers, frontline soldiers, researchers, the international community, and society since it provides a lot of new information that is helpful in refining strategies and combating influential stressors.", "doi": "10.3389/fpsyg.2021.751882", "pmid": "34867641", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8636429"}], "notes": [], "created": "2021-12-12T07:07:18.693Z", "modified": "2021-12-12T07:07:36.228Z"}, {"entity": "publication", "iuid": "18e86ad4da7e436aacdfe11da55bc5f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18e86ad4da7e436aacdfe11da55bc5f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18e86ad4da7e436aacdfe11da55bc5f1"}}, "title": "Obstructive sleep apnea is an independent risk factor for severe COVID-19: a population-based study.", "authors": [{"family": "R\u00f6gnvaldsson", "given": "Kristj\u00e1n Godsk", "initials": "KG"}, {"family": "Ey\u00fe\u00f3rsson", "given": "El\u00edas S\u00e6bj\u00f6rn", "initials": "ES"}, {"family": "Emilsson", "given": "\u00d6ssur Ingi", "initials": "\u00d6I"}, {"family": "Eysteinsd\u00f3ttir", "given": "Bj\u00f6rg", "initials": "B"}, {"family": "P\u00e1lsson", "given": "Run\u00f3lfur", "initials": "R"}, {"family": "Gottfre\u00f0sson", "given": "Magn\u00fas", "initials": "M"}, {"family": "Gu\u00f0mundsson", "given": "Gunnar", "initials": "G"}, {"family": "Steingr\u00edmsson", "given": "Vilhj\u00e1lmur", "initials": "V"}], "type": "journal article", "published": "2021-11-17", "journal": {"title": "Sleep", "issn": "1550-9109", "issn-l": null}, "abstract": "Obstructive sleep apnea (OSA) has been proposed as a risk factor for severe COVID-19. Confounding is an important consideration as OSA is associated with several known risk factors for severe COVID-19. Our aim was to assess the association of OSA with hospitalization due to COVID-19 using a population-based cohort with detailed information on OSA and comorbidities.\n\nIncluded were all community-dwelling Icelandic citizens 18 years of age and older diagnosed with SARS-CoV-2 infection in 2020. Data on demographics, comorbidities, and outcomes of COVID-19 was obtained from centralized national registries. Diagnosis of OSA was retrieved from the centralized Sleep Department Registry at Landspitali-The National University Hospital. Severe COVID-19 was defined as the composite outcome of hospitalization and death. The associations between OSA and the outcome were expressed as odds ratios (OR) with 95% confidence intervals (95% CI), calculated using logistic regression models and inverse probability weighting.\n\nA total of 4,756 individuals diagnosed with SARS-CoV-2 infection in Iceland were included in the study (1.3% of the Icelandic population), of whom 185 had a diagnosis of OSA. In total, 238 were hospitalized or died, 38 of whom had OSA. Adjusted for age, sex, and BMI, OSA was associated with poor outcome (OR 2.2, 95% CI 1.4 -3.5). This association was slightly attenuated (OR 2.0, 95% CI 2.0, 1.2-3.2) when adjusted for demographic characteristics and various comorbidities.\n\nOSA was associated with twofold increase in risk of severe COVID-19, and the association was not explained by obesity or other comorbidities.", "doi": "10.1093/sleep/zsab272", "pmid": "34791469", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6430441"}], "notes": [], "created": "2021-11-26T14:10:27.773Z", "modified": "2021-11-26T14:10:27.786Z"}, {"entity": "publication", "iuid": "2db2e9c0e8964a27b948c7c2d484f5bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2db2e9c0e8964a27b948c7c2d484f5bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2db2e9c0e8964a27b948c7c2d484f5bf"}}, "title": "Impact of the Double Mutants on Spike Protein of SARS-CoV-2 B.1.617 Lineage on the Human ACE2 Receptor Binding: A Structural Insight.", "authors": [{"family": "Khan", "given": "Mohd Imran", "initials": "MI"}, {"family": "Baig", "given": "Mohammad Hassan", "initials": "MH", "orcid": "0000-0001-8227-4838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1fe7992c2c94f768b7b8d781c99c618.json"}}, {"family": "Mondal", "given": "Tanmoy", "initials": "T"}, {"family": "Alorabi", "given": "Mohammed", "initials": "M", "orcid": "0000-0002-4326-6066", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab180e94a4ae4dcf99c5f8ae79697e44.json"}}, {"family": "Sharma", "given": "Tanuj", "initials": "T"}, {"family": "Dong", "given": "Jae-June", "initials": "JJ", "orcid": "0000-0002-2420-2155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0de75e6c65df43d9a886bf95063d625a.json"}}, {"family": "Cho", "given": "Jae Yong", "initials": "JY"}], "type": "journal article", "published": "2021-11-17", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "11", "issn-l": "1999-4915"}, "abstract": "The recent emergence of novel SARS-CoV-2 variants has threatened the efforts to contain the COVID-19 pandemic. The emergence of these \"variants of concern\" has increased immune escape and has supplanted the ancestral strains. The novel variants harbored by the B.1.617 lineage (kappa and delta) carry mutations within the receptor-binding domain of spike (S) protein (L452R + E484Q and L452R + T478K), the region binding to the host receptor. The double mutations carried by these novel variants are primarily responsible for an upsurge number of COVID-19 cases in India. In this study, we thoroughly investigated the impact of these double mutations on the binding capability to the human host receptor. We performed several structural analyses and found that the studied double mutations increase the binding affinity of the spike protein to the human host receptor (ACE2). Furthermore, our study showed that these double mutants might be a dominant contributor enhancing the receptor-binding affinity of SARS-CoV-2 and consequently making it more stable. We also investigated the impact of these mutations on the binding affinity of two monoclonal antibodies (Abs) (2-15 and LY-CoV555) and found that the presence of the double mutations also hinders its binding with the studied Abs. The principal component analysis, free energy landscape, intermolecular interaction, and other investigations provided a deeper structural insight to better understand the molecular mechanism responsible for increased viral transmissibility of these variants.", "doi": "10.3390/v13112295", "pmid": "34835101", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "v13112295"}, {"db": "pmc", "key": "PMC8625741"}], "notes": [], "created": "2021-12-18T18:14:46.920Z", "modified": "2021-12-18T18:14:47.044Z"}, {"entity": "publication", "iuid": "6f4adb0b60cf45539307221b47720cde", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f4adb0b60cf45539307221b47720cde.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f4adb0b60cf45539307221b47720cde"}}, "title": "Impact of COVID-19 on global burn care.", "authors": [{"family": "Laura", "given": "Pompermaier", "initials": "P"}, {"family": "Jos\u00e9", "given": "Adorno", "initials": "A"}, {"family": "Nikki", "given": "Allorto", "initials": "A"}, {"family": "Khaled", "given": "Altarrah", "initials": "A"}, {"family": "Barret", "given": "Juan P", "initials": "JP"}, {"family": "Jeffery", "given": "Carter", "initials": "C"}, {"family": "Shobha", "given": "Chamania", "initials": "C"}, {"family": "Jack", "given": "Chong Si", "initials": "CS"}, {"family": "Scott", "given": "Corlew", "initials": "C"}, {"family": "Nadia", "given": "Depetris", "initials": "D"}, {"family": "Moustafa", "given": "Elmasry", "initials": "E"}, {"family": "Liao", "given": "Junlin", "initials": "J"}, {"family": "Josef", "given": "Haik", "initials": "H"}, {"family": "Briana", "given": "Horwath", "initials": "H"}, {"family": "Sunil", "given": "Keswani", "initials": "K"}, {"family": "Tetsuro", "given": "Kiyozumi", "initials": "K"}, {"family": "Jorge", "given": "Leon-Villapalos", "initials": "LV"}, {"family": "Gaoxing", "given": "Luo", "initials": "L"}, {"family": "Hajime", "given": "Matsumura", "initials": "M"}, {"family": "Ariel", "given": "Miranda-Altamirano", "initials": "MA"}, {"family": "Naiem", "given": "Moiemen", "initials": "M"}, {"family": "Kiran", "given": "Nakarmi", "initials": "N"}, {"family": "Nawar", "given": "Ahmed", "initials": "A"}, {"family": "Faustin", "given": "Ntirenganya", "initials": "N"}, {"family": "Anthony", "given": "Olekwu", "initials": "O"}, {"family": "Tom", "given": "Potokar", "initials": "P"}, {"family": "Liang", "given": "Qiao", "initials": "Q"}, {"family": "Man", "given": "Rai Shankar", "initials": "RS"}, {"family": "Ingrid", "given": "Steinvall", "initials": "S"}, {"family": "Ahmed", "given": "Tanveer", "initials": "T"}, {"family": "Molina", "given": "Vana Luiz Philipe", "initials": "VLP"}, {"family": "Shelley", "given": "Wall", "initials": "W"}, {"family": "Mark", "given": "Fisher", "initials": "F"}], "type": "journal article", "published": "2021-11-17", "journal": {"title": "Burns", "issn": "1879-1409", "issn-l": null}, "abstract": "Worldwide, different strategies have been chosen to face the COVID-19-patient surge, often affecting access to health care for other patients. This observational study aimed to investigate whether the standard of burn care changed globally during the pandemic, and whether country\u00b4s income, geographical location, COVID-19-transmission pattern, and levels of specialization of the burn units affected reallocation of resources and access to burn care.\n\nThe Burn Care Survey is a questionnaire developed to collect information on the capacity to provide burn care by burn units around the world, before and during the pandemic. The survey was distributed between September and October 2020. McNemar`s test analyzed differences between services provided before and during the pandemic, \u03c72 or Fisher's exact test differences between groups. Multivariable logistic regression analyzed the independent effect of different factors on keeping the burn units open during the pandemic.\n\nThe survey was completed by 234 burn units in 43 countries. During the pandemic, presence of burn surgeons did not change (p = 0.06), while that of anesthetists and dedicated nursing staff was reduced (<0.01), and so did the capacity to manage patients in all age groups (p = 0.04). Use of telemedicine was implemented (p < 0.01), collaboration between burn centers was not. Burn units in LMICs and LICs were more likely to be closed, after adjustment for other factors.\n\nDuring the pandemic, most burn units were open, although availability of standard resources diminished worldwide. The use of telemedicine increased, suggesting the implementation of new strategies to manage burns. Low income was independently associated with reduced access to burn care.", "doi": "10.1016/j.burns.2021.11.010", "pmid": "34903416", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0305-4179(21)00312-0"}, {"db": "pmc", "key": "PMC8664090"}], "notes": [], "created": "2021-12-18T17:59:08.739Z", "modified": "2021-12-18T17:59:08.775Z"}, {"entity": "publication", "iuid": "9bd7f6ad9b65462e99a211e5e7ebbfbb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9bd7f6ad9b65462e99a211e5e7ebbfbb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9bd7f6ad9b65462e99a211e5e7ebbfbb"}}, "title": "Duration of SARS-CoV-2 viremia and its correlation to mortality and inflammatory parameters in patients hospitalized for COVID-19: a cohort study.", "authors": [{"family": "Hagman", "given": "Karl", "initials": "K"}, {"family": "Hedenstierna", "given": "Magnus", "initials": "M"}, {"family": "Rudling", "given": "Johan", "initials": "J"}, {"family": "Gille-Johnson", "given": "Patrik", "initials": "P"}, {"family": "Hammas", "given": "Berit", "initials": "B"}, {"family": "Grabbe", "given": "Malin", "initials": "M"}, {"family": "Jakobsson", "given": "Jan", "initials": "J"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Ursing", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2021-11-17", "journal": {"title": "Diagn Microbiol Infect Dis", "issn": "1879-0070", "volume": "102", "issue": "3", "pages": "115595", "issn-l": null}, "abstract": "SARS-CoV-2 viremia at admission is associated with high risk for mortality. However, longitudinal data on viremia duration are limited. Viremic patients hospitalized for COVID-19 were included in a cohort. Time to serum viral clearance and the effect of viremia duration on the odds of mortality were calculated. One hundred and twenty-one viremic patients were included. Median age was 62 (IQR 52-71) years and 68% were males. The total in-hospital mortality of the cohort was 33%. Median time from admission to serum viral clearance was 7 (95% CI 6-8) days. Duration of viremia showed a relative risk ratio of 1.40 (95% CI 1.02-1.92) for the odds of mortality in an adjusted multinomial logistic regression. Serum viral clearance coincided with defervescence and decreasing C-reactive protein. Median time to serum viral clearance was 7 days after admission. The odds of mortality increased with 40% for each additional day of viremia.", "doi": "10.1016/j.diagmicrobio.2021.115595", "pmid": "34896666", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0732-8893(21)00286-8"}, {"db": "pmc", "key": "PMC8595972"}], "notes": [], "created": "2021-12-18T18:00:53.948Z", "modified": "2021-12-18T18:00:53.984Z"}, {"entity": "publication", "iuid": "e4bfeb90baee400ea2e8bdf13019a27d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e4bfeb90baee400ea2e8bdf13019a27d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e4bfeb90baee400ea2e8bdf13019a27d"}}, "title": "Critical care nurses' experiences of working during the first phase of the COVID-19 pandemic - Applying the Person-centred Practice Framework.", "authors": [{"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Nordin", "given": "Anna", "initials": "A"}, {"family": "Engstr\u00f6m", "given": "\u00c5sa", "initials": "\u00c5"}], "type": "journal article", "published": "2021-11-17", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "pages": "103179", "issn-l": null}, "abstract": "The aim of the study was to deductively study person-centred care, based on critical care nurses' experiences during the first phase of the CoViD-19 pandemic.\n\nThe study used a qualitative design.\n\nData collection was conducted as individual interviews and was analysed with qualitative content analysis with a deductive approach.\n\nSix critical care nurses working in a special CoViD-19 intensive care unit during the first phase of the pandemic participated.\n\nThe findings are presented within the four domains of person-centred practice: the prerequisites, the care environment, person-centred processes and person-centred outcomes. While the ambition and knowledge about how to work in accordance with person-centred practice were high, there were several obstacles to perform it.\n\nWe need to prepare ahead of time so that nurses have optimal organisational prerequisites to be able to work in accordance with person-centred practice, also during pandemics and other crisis, which means to be able to give nursing care in accordance with the ill person's needs and resources.", "doi": "10.1016/j.iccn.2021.103179", "pmid": "34895797", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(21)00168-3"}, {"db": "pmc", "key": "PMC8595352"}], "notes": [], "created": "2021-12-18T18:02:17.054Z", "modified": "2021-12-18T18:02:17.065Z"}, {"entity": "publication", "iuid": "3a3a2ac661554126906792aff64d19e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a3a2ac661554126906792aff64d19e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a3a2ac661554126906792aff64d19e2"}}, "title": "Flow as a Key Predictor of Subjective Well-Being Among Chinese University Students: A Chain Mediating Model.", "authors": [{"family": "Wu", "given": "Jun", "initials": "J"}, {"family": "Xie", "given": "Mei", "initials": "M"}, {"family": "Lai", "given": "Yao", "initials": "Y"}, {"family": "Mao", "given": "Yanhui", "initials": "Y"}, {"family": "Harmat", "given": "Laszlo", "initials": "L"}], "type": "journal article", "published": "2021-11-16", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "743906", "issn-l": "1664-1078"}, "abstract": "The present study investigated a conceptual model by testing flow experience and subjective well-being of university students during Coronavirus Diseas-19 (COVID-19) via considering their underlying mechanisms of academic self-efficacy and self-esteem. A total of 1,109 Chinese university students completed a questionnaire containing scales of subjective well-being, flow, academic self-efficacy, and self-esteem. Results yielded from the structural equation modeling analysis indicated a significant and positive association between flow experience and subjective well-being, and such an association was sequentially mediated by academic self-efficacy and self-esteem. Findings also provided empirical evidence for the proposed model highlighting the significant role of flow experience at the higher educational context in predicting subjective well-being of Chinese university students, and how such a relation can be supported by suggested mediating roles academic self-efficacy and self-esteem played.", "doi": "10.3389/fpsyg.2021.743906", "pmid": "34867624", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8636857"}], "notes": [], "created": "2021-12-12T07:06:54.204Z", "modified": "2021-12-12T07:06:54.218Z"}, {"entity": "publication", "iuid": "886aeb7ea151492486db7977a020afe9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/886aeb7ea151492486db7977a020afe9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/886aeb7ea151492486db7977a020afe9"}}, "title": "COVID-19 and risk of subsequent life-threatening secondary infections: a matched cohort study in UK Biobank.", "authors": [{"family": "Hou", "given": "Can", "initials": "C"}, {"family": "Hu", "given": "Yihan", "initials": "Y"}, {"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Chen", "given": "Wenwen", "initials": "W"}, {"family": "Zeng", "given": "Yu", "initials": "Y"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Sun", "given": "Yajing", "initials": "Y"}, {"family": "Qu", "given": "Yuanyuan", "initials": "Y"}, {"family": "Gottfre\u00f0sson", "given": "Magn\u00fas", "initials": "M"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "journal article", "published": "2021-11-16", "journal": {"title": "BMC Med", "issn": "1741-7015", "volume": "19", "issue": "1", "pages": "301", "issn-l": null}, "abstract": "With the increasing number of people infected with and recovered from coronavirus disease 2019 (COVID-19), the extent of major health consequences of COVID-19 is unclear, including risks of severe secondary infections.\n\nBased on 445,845 UK Biobank participants registered in England, we conducted a matched cohort study where 5151 individuals with a positive test result or hospitalized with a diagnosis of COVID-19 were included in the exposed group. We then randomly selected up to 10 matched individuals without COVID-19 diagnosis for each exposed individual (n = 51,402). The life-threatening secondary infections were defined as diagnoses of severe secondary infections with high mortality rates (i.e., sepsis, endocarditis, and central nervous system infections) from the UK Biobank inpatient hospital data, or deaths from these infections from mortality data. The follow-up period was limited to 3 months after the initial COVID-19 diagnosis. Using a similar study design, we additionally constructed a matched cohort where exposed individuals were diagnosed with seasonal influenza from either inpatient hospital or primary care data between 2010 and 2019 (6169 exposed and 61,555 unexposed individuals). After controlling for multiple confounders, Cox models were used to estimate hazard ratios (HRs) of life-threatening secondary infections after COVID-19 or seasonal influenza.\n\nIn the matched cohort for COVID-19, 50.22% of participants were male, and the median age at the index date was 66 years. During a median follow-up of 12.71 weeks, the incidence rate of life-threatening secondary infections was 2.23 (123/55.15) and 0.25 (151/600.55) per 1000 person-weeks for all patients with COVID-19 and their matched individuals, respectively, which corresponded to a fully adjusted HR of 8.19 (95% confidence interval [CI] 6.33-10.59). The corresponding HR of life-threatening secondary infections among all patients with seasonal influenza diagnosis was 4.50, 95% CI 3.34-6.08 (p for difference < 0.01). Also, elevated HRs were observed among hospitalized individuals for life-threatening secondary infections following hospital discharge, both in the COVID-19 (HR = 6.28 [95% CI 4.05-9.75]) and seasonal influenza (6.01 [95% CI 3.53-10.26], p for difference = 0.902) cohorts.\n\nCOVID-19 patients have increased subsequent risks of life-threatening secondary infections, to an equal extent or beyond risk elevations observed for patients with seasonal influenza.", "doi": "10.1186/s12916-021-02177-0", "pmid": "34781951", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12916-021-02177-0"}, {"db": "pmc", "key": "PMC8592806"}], "notes": [], "created": "2021-11-26T14:12:01.306Z", "modified": "2021-11-26T14:12:01.341Z"}, {"entity": "publication", "iuid": "ba2274ccc726426ea87ac013ad38e11c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ba2274ccc726426ea87ac013ad38e11c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ba2274ccc726426ea87ac013ad38e11c"}}, "title": "Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models.", "authors": [{"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Mandolesi", "given": "Marco", "initials": "M"}, {"family": "Urgard", "given": "Egon", "initials": "E"}, {"family": "Kim", "given": "Changil", "initials": "C"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Perez Vidakovics", "given": "Laura", "initials": "L"}, {"family": "Pankow", "given": "Alec", "initials": "A"}, {"family": "Smith", "given": "Natalie L", "initials": "NL"}, {"family": "Castro Dopico", "given": "Xaquin", "initials": "X"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}, {"family": "Coquet", "given": "Jonathan M", "initials": "JM"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Murrell", "given": "Ben", "initials": "B"}], "type": "journal article", "published": "2021-11-16", "journal": {"title": "Cell Rep Med", "issn": "2666-3791", "issn-l": "2666-3791", "volume": "2", "issue": "11", "pages": "100450"}, "abstract": "Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) with resistance to neutralizing antibodies are threatening to undermine vaccine efficacy. Vaccination and infection have led to widespread humoral immunity against the pandemic founder (Wu-Hu-1). Against this background, it is critical to assess the outcomes of subsequent immunization with variant antigens. It is not yet clear whether heterotypic boosts would be compromised by original antigenic sin, where pre-existing responses to a prior variant dampen responses to a new one, or whether the memory B cell repertoire would bridge the gap between Wu-Hu-1 and VOCs. We show, in macaques immunized with Wu-Hu-1 spike, that a single dose of adjuvanted beta variant receptor binding domain (RBD) protein broadens neutralizing antibody responses to heterologous VOCs. Passive transfer of plasma sampled after Wu-Hu-1 spike immunization only partially protects K18-hACE2 mice from lethal challenge with a beta variant isolate, whereas plasma sampled following heterotypic RBD boost protects completely against disease.", "doi": "10.1016/j.xcrm.2021.100450", "pmid": "34723224", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Funder: VR": null, "Category: Genomics & transcriptomics": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "S2666-3791(21)00318-9"}, {"db": "pmc", "key": "PMC8536561"}, {"db": "URL", "key": "https://github.com/MurrellGroup/VOCfreq", "description": "Code used for analyses"}], "notes": [], "created": "2021-11-02T15:33:54.198Z", "modified": "2021-11-18T13:48:31.567Z"}, {"entity": "publication", "iuid": "3828890895b942c8bd11d40e982ecb75", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3828890895b942c8bd11d40e982ecb75.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3828890895b942c8bd11d40e982ecb75"}}, "title": "Predicting Work-Life Conflict: Types and Levels of Enacted and Preferred Work-Nonwork Boundary (In)Congruence and Perceived Boundary Control.", "authors": [{"family": "Mellner", "given": "Christin", "initials": "C"}, {"family": "Peters", "given": "Pascale", "initials": "P"}, {"family": "Dragt", "given": "Maria Johanna", "initials": "MJ"}, {"family": "Toivanen", "given": "Susanna", "initials": "S"}], "type": "journal article", "published": "2021-11-15", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "772537", "issn-l": "1664-1078"}, "abstract": "In 2020, everyday life changed dramatically for employees worldwide as a result of the outbreak of the Covid-19 pandemic, where an estimated 558 million employees started working from home. The pandemic, therefore, marks a fundamental shift of individuals' work-nonwork boundaries, which can impact work-life conflict. In particular, the interplay between individuals' enacted boundaries (degree to which they separate/segment or blend/integrate work-nonwork), preferred boundaries (degree of preferred segmentation or integration of work-nonwork), and perceived control over work-nonwork boundaries, may relate to work-life conflict. This study, the first to the best of our knowledge, examines whether different types and levels of work-nonwork boundary (in)congruence matter for work-life conflict, and whether perceived boundary control moderates these relationships. Boundary (in)congruence represents the degree of (mis)fit between enacted and preferred segmentation or integration. Several types of (in)congruence are distinguished: \"segmentation congruence\" (enacting and preferring segmentation); \"integration congruence\" (enacting and preferring integration); \"intrusion\" (enacting integration but preferring segmentation) and \"distance\" (enacting segmentation but preferring integration). Data from 1,229 managers working in public and private organizations in Sweden was analyzed using polynomial regression analysis with response surface modeling and moderation analysis in SPSS Process. Findings showed that \"integration congruence\" was related with higher work-life conflict than \"segmentation congruence.\" Moreover, a U-shaped relationship between incongruence and work-life conflict was found: the more incongruence, the more work-life conflict. Specifically, \"intrusion\" was related to higher work-life conflict than \"distance.\" Finally, boundary control mitigated the effect of incongruence (especially \"intrusion\") on work-life conflict. From our findings, we may conclude that work-life conflict is impacted differently depending on the type and level of boundary (in)congruence. Particularly enacted and/or preferred integration may be problematic when it comes to work-life conflict, rather than just (in)congruence per se. Moreover, boundary control can be viewed as a key factor in combating work-life conflict, especially among individuals who enact integration, but prefer segmentation. Taken together, our study contributes new and substantial knowledge by showing the importance for research and HRM-policies that take into account different types and levels of boundary (in)congruence, as these are associated with different levels of work-life conflict, which, in turn, are moderated by boundary control.", "doi": "10.3389/fpsyg.2021.772537", "pmid": "34867680", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8636054"}], "notes": [], "created": "2021-12-12T07:08:00.780Z", "modified": "2021-12-12T07:08:00.794Z"}, {"entity": "publication", "iuid": "634ab65b283f4ad5ad0e20b5d53623ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/634ab65b283f4ad5ad0e20b5d53623ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/634ab65b283f4ad5ad0e20b5d53623ef"}}, "title": "Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know?", "authors": [{"family": "Bisaccia", "given": "Giandomenico", "initials": "G", "orcid": "0000-0003-4606-3093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9ff7c6f9a724caea1cae5493f4951af.json"}}, {"family": "Ricci", "given": "Fabrizio", "initials": "F", "orcid": "0000-0002-1401-6623", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1dab56ecc21e43909dcc6881ffef5892.json"}}, {"family": "Recce", "given": "Vittoria", "initials": "V"}, {"family": "Serio", "given": "Antonio", "initials": "A"}, {"family": "Iannetti", "given": "Giovanni", "initials": "G"}, {"family": "Chahal", "given": "Anwar A", "initials": "AA", "orcid": "0000-0001-7825-8827", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/792261f66ef641ab8f135eb75586ff38.json"}}, {"family": "St\u00e5hlberg", "given": "Marcus", "initials": "M"}, {"family": "Khanji", "given": "Mohammed Yunus", "initials": "MY"}, {"family": "Fedorowski", "given": "Artur", "initials": "A", "orcid": "0000-0002-5352-6327", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2ef9375bfba4311868834aec838c8a3.json"}}, {"family": "Gallina", "given": "Sabina", "initials": "S"}], "type": "journal article", "published": "2021-11-15", "journal": {"title": "J Cardiovasc Dev Dis", "issn": "2308-3425", "volume": "8", "issue": "11", "issn-l": null}, "abstract": "Post-acute sequelae of SARS-CoV-2 (PASC), or long COVID syndrome, is emerging as a major health issue in patients with previous SARS-CoV-2 infection. Symptoms commonly experienced by patients include fatigue, palpitations, chest pain, dyspnea, reduced exercise tolerance, and \"brain fog\". Additionally, symptoms of orthostatic intolerance and syncope suggest the involvement of the autonomic nervous system. Signs of cardiovascular autonomic dysfunction appear to be common in PASC and are similar to those observed in postural orthostatic tachycardia syndrome and inappropriate sinus tachycardia. In this review, we report on the epidemiology of PASC, discuss current evidence and possible mechanisms underpinning the dysregulation of the autonomic nervous system, and suggest nonpharmacological and pharmacological interventions to treat and relieve symptoms of PASC-associated dysautonomia.", "doi": "10.3390/jcdd8110156", "pmid": "34821709", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jcdd8110156"}, {"db": "pmc", "key": "PMC8621226"}], "notes": [], "created": "2021-11-26T13:04:49.442Z", "modified": "2021-12-18T18:20:39.207Z"}, {"entity": "publication", "iuid": "85651f060d974f45a6b00cb2151928c8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/85651f060d974f45a6b00cb2151928c8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/85651f060d974f45a6b00cb2151928c8"}}, "title": "COVID-19 water, sanitation, and hygiene response: Review of measures and initiatives adopted by governments, regulators, utilities, and other stakeholders in 84 countries.", "authors": [{"family": "Gin\u00e9-Garriga", "given": "Ricard", "initials": "R"}, {"family": "Delepiere", "given": "Antoine", "initials": "A"}, {"family": "Ward", "given": "Robin", "initials": "R"}, {"family": "Alvarez-Sala", "given": "Jorge", "initials": "J"}, {"family": "Alvarez-Murillo", "given": "Isabel", "initials": "I"}, {"family": "Mariezcurrena", "given": "Virginia", "initials": "V"}, {"family": "Sandberg", "given": "Henning G\u00f6ransson", "initials": "HG"}, {"family": "Saikia", "given": "Panchali", "initials": "P"}, {"family": "Avello", "given": "Pilar", "initials": "P"}, {"family": "Thakar", "given": "Kanika", "initials": "K"}, {"family": "Ibrahim", "given": "Esmaeil", "initials": "E"}, {"family": "Nouvellon", "given": "Alban", "initials": "A"}, {"family": "El Hattab", "given": "Omar", "initials": "O"}, {"family": "Hutton", "given": "Guy", "initials": "G"}, {"family": "Jim\u00e9nez", "given": "Alejandro", "initials": "A"}], "type": "journal article", "published": "2021-11-15", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "issn-l": "0048-9697", "volume": "795", "issue": null, "pages": "148789"}, "abstract": "The COVID-19 pandemic has shone a light on handwashing as an inexpensive, widely applicable response measure. In consequence, most governments have taken action to promote access to water and sanitation services for all. This paper documents an overview of initiatives and interventions that countries have implemented during the first months of the COVID-19 response. Initiatives have been identified across 84 countries worldwide, and categorized into those that aimed at securing water, sanitation, and hygiene (WASH) for all, and those that sought to provide technical and financial support to service providers. The pandemic has not hit countries in the same way. Accordingly, results show disparities in the response between and within regions, with the level of activity found in the countries varying largely in terms of ambition and scope. Hygiene promotion and infection prevention and control (IPC) has been widely adopted - at least one response measure found in 94% of mapped countries -, although not always matched in ambition with the assured availability of soap, water, and handwashing facilities. Support to vulnerable households to promote basic access to WASH services at scale was weak (38% of countries) or implemented locally (25%), and requiring additional focus, particularly in rural areas and small towns. In addition, parallel support needs to be extended to service providers or to households themselves in the form of cash transfers, in order to ensure the financial viability and the continuity of services. All lessons learned distilled from the pandemic should help strengthen the enabling environment for more resilient services in future emergencies. Areas for focus could include developing specific pandemic response strategies and plans; strengthening coordination; and establishing emergency financial support mechanisms for water operators, for example. Overall, findings presented herein contribute to enhance current and future pandemics prevention, mitigation, and recovery.", "doi": "10.1016/j.scitotenv.2021.148789", "pmid": "34243010", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(21)03861-4"}, {"db": "pmc", "key": "PMC8254381"}], "notes": [], "created": "2021-08-06T07:57:24.602Z", "modified": "2021-09-20T16:23:07.056Z"}, {"entity": "publication", "iuid": "3e7419528ada4d74b76965da0815779b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3e7419528ada4d74b76965da0815779b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3e7419528ada4d74b76965da0815779b"}}, "title": "COVID-19 vaccination in autoimmune disease (COVAD) survey protocol.", "authors": [{"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Aggarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-0986-8354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2e6226ae5e7427fbf52e180dd14e28f.json"}}, {"family": "Kardes", "given": "Sinan", "initials": "S", "orcid": "0000-0002-6311-8634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2900c3ca00da476a8914574384a3c9c2.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "O'Callaghan", "given": "Albert Selva", "initials": "AS", "orcid": "0000-0003-2823-9761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef3e202c049b44a2a5e045bac90a393a.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Cagnotto", "given": "Giovanni", "initials": "G", "orcid": "0000-0002-1682-8158", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91574e9defd848a78539eabd351940c1.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Aggarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-2089-027X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31cc5ee9caf34d889e61e31520b4399b.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "COVAD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-15", "journal": {"title": "Rheumatol Int", "issn": "1437-160X", "issn-l": null}, "abstract": "The coronavirus disease-2019 (COVID-19) pandemic continues to be a cause of unprecedented global morbidity and mortality. Whilst COVID-19 vaccination has emerged as the only tangible solution to reducing poor clinical outcomes, vaccine hesitancy continues to be an obstacle to achieving high levels of vaccine uptake. This represents particular risk to patients with autoimmune diseases, a group already at increased risk of hospitalization and poor clinical outcomes related to COVID-19 infection. Whilst there is a paucity of long-term safety and efficacy data of COVID-19 vaccination in patients with autoimmune diseases, the current evidence strongly suggests that the benefits of vaccination outweigh the risks of adverse effects and disease flares. Herein, we report the protocol of the COVID-19 Vaccination in Autoimmune Diseases (COVAD) study, an ongoing international collaborative study involving 29 countries and over 110 investigators.", "doi": "10.1007/s00296-021-05046-4", "pmid": "34779868", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00296-021-05046-4"}, {"db": "pmc", "key": "PMC8591970"}], "notes": [], "created": "2021-11-26T14:12:43.355Z", "modified": "2021-11-26T14:12:44.102Z"}, {"entity": "publication", "iuid": "58c44fae885640b0a222a91d48740176", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/58c44fae885640b0a222a91d48740176.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/58c44fae885640b0a222a91d48740176"}}, "title": "Utilization of health care services before and after media attention about fatal side effects of the AstraZeneca vaccine: a nation-wide register-based event study.", "authors": [{"family": "Larsen", "given": "Vilde Bergstad", "initials": "VB"}, {"family": "Gr\u00f8sland", "given": "Mari", "initials": "M"}, {"family": "Telle", "given": "Kjetil", "initials": "K"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2021-11-13", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "issn-l": null, "volume": "21", "issue": "1", "pages": "1229"}, "abstract": "Survey studies have found that vaccinated persons tend to report more side effects after being given information about side effects rather than benefits. However, the impact of high media attention about vaccine-related side effects on the utilization of health care is unknown. We aimed to assess whether utilization of health care services for newly vaccinated health care workers changed after media attention about fatal side effects of the AstraZeneca vaccine on March 11th, 2021, and whether changes differed by age, sex, or occupation.\r\n\r\nWe utilized individual-level data on health care use, vaccination, employment, and demographics available in the Norwegian emergency preparedness register Beredt C19. In all 99,899 health care workers in Norway who were vaccinated with AstraZeneca between February 11th and March 11th, we used an event-study design with a matched comparison group to compare the change in primary and inpatient specialist care use from 14 days before to 14 days after the information shock on March 11th, 2021.\r\n\r\nPrimary health care use increased with 8.2 daily consultations per 1000 health care workers (95% CI 7.51 to 8.89) the week following March 11th for those vaccinated with AstraZeneca (n = 99,899), compared with no increase for the unvaccinated comparison group (n = 186,885). Utilization of inpatient care also increased with 0.8 daily hospitalizations per 1000 health care workers (95% CI 0.37 to 1.23) in week two after March 11th. The sharpest increase in daily primary health care use in the first week after March 11th was found for women aged 18-44 (10.6 consultations per 1000, 95% CI 9.52 to 11.68) and for cleaners working in the health care sector (9.8 consultations per 1000, 95% CI 3.41 to 16.19).\r\n\r\nHealth care use was higher after the media reports of a few cases of fatal or severe side effects of the AstraZeneca vaccine. Our results suggest that the reports did not only lead vaccinated individuals to contact primary health care more, but also that physicians referred and treated more cases to specialist care after the new information.", "doi": "10.1186/s12913-021-07233-2", "pmid": "34774045", "labels": {"Type: Journal article": null, "Topics: Register-based research": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-021-07233-2"}, {"db": "pmc", "key": "PMC8590367"}], "notes": [], "created": "2021-11-26T15:07:46.550Z", "modified": "2021-11-29T06:06:38.104Z"}, {"entity": "publication", "iuid": "550af56a537a48ef9b110f14802614cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/550af56a537a48ef9b110f14802614cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/550af56a537a48ef9b110f14802614cb"}}, "title": "Just how common is TTS after a second dose of the ChAdOx1 nCov-19 vaccine? - Authors' reply.", "authors": [{"family": "Bhuyan", "given": "Prakash", "initials": "P"}, {"family": "Medin", "given": "Jennie", "initials": "J"}, {"family": "da Silva", "given": "Hugo Gomes", "initials": "HG"}, {"family": "Yadavalli", "given": "Madhavi", "initials": "M"}, {"family": "Nord", "given": "Magnus", "initials": "M"}], "type": "letter", "published": "2021-11-13", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "398", "issue": "10313", "pages": "1801-1802", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(21)02317-5", "pmid": "34774142", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)02317-5"}], "notes": [], "created": "2021-11-26T14:29:42.406Z", "modified": "2021-11-26T14:29:42.420Z"}, {"entity": "publication", "iuid": "194df91105ef49e1ad019cfe7228e489", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/194df91105ef49e1ad019cfe7228e489.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/194df91105ef49e1ad019cfe7228e489"}}, "title": "General stress among young adults with asthma during the COVID-19 pandemic.", "authors": [{"family": "Ekstr\u00f6m", "given": "Sandra", "initials": "S"}, {"family": "Mogensen", "given": "Ida", "initials": "I"}, {"family": "Georgelis", "given": "Antonios", "initials": "A"}, {"family": "Westman", "given": "Marit", "initials": "M"}, {"family": "Almqvist", "given": "Catarina", "initials": "C"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Bergstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "BAMSE COVID-19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-13", "journal": {"title": "J Allergy Clin Immunol Pract", "issn": "2213-2201", "issn-l": null}, "abstract": "The COVID-19 pandemic has profoundly affected the lives of the global population.\n\nTo explore anxiety and stress in relation to COVID-19 among young adults, and the potential influence of asthma and allergic rhinitis.\n\nThis cross-sectional study included 1,644 participants from the population-based birth cohort BAMSE, participating in a follow-up at 24 years of age and a COVID-19 follow-up conducted in August-November 2020 (mean age 25.3 years). Anxiety and concern related to COVID-19 were analyzed as general anxiety, concern of own health and health of family members, and contact with online healthcare providers due to concern about COVID-19. Stress was measured with the perceived stress scale (PSS-10).\n\nAround half of the participants reported increased anxiety due to COVID-19 and this was more common among females (57.0%, compared to 42.6% in males, p<0.001). Young adults with asthma reported more concern about their own health (adjusted odds ratio (adj OR): 1.50, 95% confidence interval (CI): 1.12-2.02) and perceived stress (adjusted regression coefficient (adj \u03b2): 1.49 CI: 0.52-2.45) compared to peers without asthma, and this was more pronounced among females and those with uncontrolled asthma. Symptoms of allergic rhinitis were not associated with increased concern or anxiety in relation to COVID-19.\n\nYoung adults with asthma experience more COVID-19 related health concerns, compared to those without asthma; especially females and participants with uncontrolled asthma This needs to be considered in the care of young people with asthma.", "doi": "10.1016/j.jaip.2021.10.069", "pmid": "34785389", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2213-2198(21)01260-5"}, {"db": "pmc", "key": "PMC8590620"}], "notes": [], "created": "2021-11-26T14:11:36.607Z", "modified": "2021-11-26T14:11:36.621Z"}, {"entity": "publication", "iuid": "0dcc8509723f41338670ce7ef4e5bb71", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0dcc8509723f41338670ce7ef4e5bb71.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0dcc8509723f41338670ce7ef4e5bb71"}}, "title": "Gaming Activity and Possible Changes in Gaming Behavior Among Young People During the COVID-19 Pandemic: Cross-sectional Online Survey Study.", "authors": [{"family": "Claesdotter-Knutsson", "given": "Emma", "initials": "E"}, {"family": "Andr\u00e9", "given": "Frida", "initials": "F"}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-11-13", "journal": {"title": "JMIR Serious Games", "issn": "2291-9279", "issn-l": null}, "abstract": "Young people's daily lives and social interactions changed remarkably during the COVID-19 pandemic as schools and cinemas closed, leisure activities were cancelled, and gatherings were regulated. Questions have been raised by the media, schools, policymakers and research communities about the effect on young people's online behaviors.\n\nThe aim of this cross-sectional study was to study self-reported changes in gaming, focusing on a younger section of the population during the COVID-19 pandemic in Sweden. We also wanted to look at potential risk factors behind problematic gaming during the pandemic, including gaming patterns, gambling behavior, psychological distress, certain sociodemographic characteristics, health factors, and school situation.\n\nThis was an anonymous online survey study of web panel participants in Sweden (N=1,501) to study changes in gaming behaviors during the COVID-19 pandemic. Self-reported increases in gaming were analyzed in logistic regressions against sociodemographic and health factors.\n\nWithin the whole study population that reported changes in gaming activity we found significant differences in age, employment status, disposable income, whether they ever played on loot boxes, time spent at home, school attendance, psychological distress, gambling and gaming problems, and significant differences in changes in alcohol consumption and changes in exercise habits. When examining the age group 16-24 years old that reported changes in gaming activity, we found significant differences within the group in disposable income, time at home and school attendance. When examining the age group 25-39 years old that reported changes in gaming activity, we found significant differences within the group in employment status, disposable income, time spent at home, whether the respondents are studying, school attendance level, psychological distress, gaming problems, as well as significant differences in changes in alcohol consumption and changes in exercise habits. Psychological distress (all age groups analyzed together; age group 25-39 years old), drinking less alcohol (all age groups analyzed together), spending more time at home (all age groups analyzed together), gaming problems and exercising less (age group 25-39 years old) were positively correlated to a self-reported increase in gaming activity. Being employed (age group 25-39 years old) and being over 40 years of age (all age groups analyzed together) were negatively correlated to increased gaming. We found no significant correlations in the age group 16-24 years old.\n\nThose who reported increased gaming during the COVID-19 pandemic were more likely to be 16-39 years old. In the age group 25-39 years old the increase was associated with psychological distress, reporting less exercise and being unemployed. COVID-19 may present a risk factor of increased online gaming in a small but vulnerable group. More research and preferably longitudinal studies are needed in the field of gaming and effects of the COVID-19 pandemic.", "doi": "10.2196/33059", "pmid": "34817386", "labels": {"Type: Journal article": null, "Category: Other": null, "Topics: Register-based research": null}, "xrefs": [], "notes": [], "created": "2021-11-26T13:06:15.801Z", "modified": "2021-12-18T18:22:51.084Z"}, {"entity": "publication", "iuid": "be53c97c1d794cc586bdddce6d92d246", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be53c97c1d794cc586bdddce6d92d246.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be53c97c1d794cc586bdddce6d92d246"}}, "title": "Beneficial Effects of Anticoagulants on the Clinical Outcomes of COVID-19 Patients.", "authors": [{"family": "Jamil", "given": "Zubia", "initials": "Z"}, {"family": "Khan", "given": "Azmat Ali", "initials": "AA", "orcid": "0000-0001-5955-3783", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fbf30007a9a4702b4fb2171acf8b7a4.json"}}, {"family": "Khalid", "given": "Samreen", "initials": "S"}, {"family": "Asghar", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-9017-2206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0e95806bb4a4dca8363a6d9618c678d.json"}}, {"family": "Muhammad", "given": "Khalid", "initials": "K", "orcid": "0000-0001-6488-1722", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a33153a6137841cbaec30e195174ddff.json"}}, {"family": "Waheed", "given": "Yasir", "initials": "Y", "orcid": "0000-0002-5789-4215", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9dc6b28db595446b8d4fd02142a077e0.json"}}], "type": "journal article", "published": "2021-11-13", "journal": {"title": "Antibiotics (Basel)", "issn": "2079-6382", "volume": "10", "issue": "11", "issn-l": null}, "abstract": "(1) Background: Severe coronavirus disease can be complicated by a hypercoagulable state in conjunction with sepsis, increasing the risk of venous thromboembolism. This study aimed to observe the effect of anticoagulants on 30-day high-dependency unit (HDU) outcomes of moderate to severe coronavirus disease 2019 (COVID-19) patients of a tertiary care hospital at Rawalpindi, Pakistan. (2) Methods: A retrospective propensity-based case-control study was carried out to examine COVID-19 patients admitted to the HDU. Patient groups who did and did not receive anticoagulants were labeled as \"anticoagulant\" and \"non-anticoagulant\", respectively. Case-control matching (1:1) was performed via propensity scores (calculated by a regression model). Kaplan-Meier and logrank analyses were used to study survival probability. Single predictors of outcomes were determined by Cox regression analysis. (3) Results: The anticoagulant group had elevated D-dimers, advanced age, more comorbidities and a higher frequency of severe disease compared to the non-anticoagulant group (p < 0.05). Therefore, 47 cases and 47 matched controls were selected based on their propensity scores. The primary endpoint was outcome (survived vs. died). The 30-day in-HDU mortality was 25.5% for cases and 61.7% for controls (p = 0.0004). The median time from admission to death was 16 days for the case group and 7 days for the control group (p < 0.0001). The 30-day mortality was 19.1% for the enoxaparin group and 16.4% for the heparin group (p > 0.05). Enoxaparin (therapeutic and prophylactic doses) and heparin (prophylactic dose) were found to be independent factors affecting the outcomes of these patients (p < 0.001). (4) Conclusions: Anticoagulants play a beneficial role in reducing mortality among COVID-19 patients. Both anticoagulant formulations, enoxaparin (therapeutic and prophylactic doses) and heparin (prophylactic dose), were associated with improving survival among these patients.", "doi": "10.3390/antibiotics10111394", "pmid": "34827332", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "antibiotics10111394"}, {"db": "pmc", "key": "PMC8615249"}], "notes": [], "created": "2021-12-18T18:17:40.214Z", "modified": "2021-12-18T18:17:40.354Z"}, {"entity": "publication", "iuid": "aa0ac8acb86d4d32907c7a91390df8c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aa0ac8acb86d4d32907c7a91390df8c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aa0ac8acb86d4d32907c7a91390df8c0"}}, "title": "Partial oral antibiotic treatment for bacterial brain abscess: an open-label randomized non-inferiority trial (ORAL).", "authors": [{"family": "Bodilsen", "given": "Jacob", "initials": "J", "orcid": "0000-0002-7398-814X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d14a292f44b4962bb6d543d059debc8.json"}}, {"family": "Brouwer", "given": "Matthijs C", "initials": "MC"}, {"family": "van de Beek", "given": "Diederik", "initials": "D"}, {"family": "Tattevin", "given": "Pierre", "initials": "P"}, {"family": "Tong", "given": "Steven", "initials": "S"}, {"family": "Naucler", "given": "Pontus", "initials": "P"}, {"family": "Nielsen", "given": "Henrik", "initials": "H"}], "type": "equivalence trial", "published": "2021-11-12", "journal": {"title": "Trials", "issn": "1745-6215", "volume": "22", "issue": "1", "pages": "796", "issn-l": null}, "abstract": "The advised standard treatment for bacterial brain abscess following surgery is 6 to 8 weeks of intravenous (IV) antibiotic treatment, but an early switch to oral antibiotic treatment has been suggested to be equally effective.\n\nThis investigator-initiated, international, multi-center, parallel group, open-label, randomized (1:1 allocation) controlled trial will examine if oral treatment after 2 weeks of IV antibiotic therapy is non-inferior to standard 6-8 weeks of IV antibiotics for bacterial brain abscess in adults (\u2265 18 years of age). The study will be conducted at hospitals across Denmark, the Netherlands, France, Australia, and Sweden. Exclusion criteria are severe immunocompromise or impaired gastro-intestinal absorption, pregnancy, device-related brain abscesses, and brain abscess caused by nocardia, tuberculosis, or Pseudomonas spp. The primary objective is a composite endpoint at 6 months after randomization consisting of all-cause mortality, intraventricular rupture of brain abscess, unplanned re-aspiration or excision of brain abscess, relapse, or recurrence. The primary endpoint will be adjudicated by an independent blinded endpoint committee. Secondary outcomes include extended Glasgow Outcome Scale scores and all-cause mortality at end of treatment as well as 3, 6, and 12 months since randomization, completion of assigned treatment, IV catheter associated complications, durations of admission and antibiotic treatment, severe adverse events, quality of life scores, and cognitive evaluations. The planned sample size is 450 patients for a one-sided alpha of 0.025 and a power of 90% to exclude a difference in favor of standard treatment of more than 10%. Date of initiation of first study center was November 3, 2020, with active recruitment for 3 years and follow-up for 1 year of all patients.\n\nThe results of this study may guide future recommendations for treatment of bacterial brain abscess. If early transition to oral antibiotics proves non-inferior to standard IV treatment, this will provide considerable health and costs benefits.\n\nClinicalTrials.gov NCT04140903, first registered 28.10.2019. EudraCT number: 2019-002845-39, first registered 03.07.2019.", "doi": "10.1186/s13063-021-05783-8", "pmid": "34772441", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13063-021-05783-8"}, {"db": "pmc", "key": "PMC8588941"}, {"db": "ClinicalTrials.gov", "key": "NCT04140903"}], "notes": [], "created": "2021-11-26T15:08:14.926Z", "modified": "2021-11-26T15:08:14.985Z"}, {"entity": "publication", "iuid": "00e2bf08d8c844b4a437f7a44ec4e7d2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/00e2bf08d8c844b4a437f7a44ec4e7d2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/00e2bf08d8c844b4a437f7a44ec4e7d2"}}, "title": "The association between first and second wave COVID-19 mortality in Italy.", "authors": [{"family": "Vinceti", "given": "Marco", "initials": "M", "orcid": "0000-0002-0551-2473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a25953d69dcd4b9bb597385be88340bc.json"}}, {"family": "Filippini", "given": "Tommaso", "initials": "T", "orcid": "0000-0003-2100-0344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/caaa012b164e4fe3962d2cce410cd008.json"}}, {"family": "Rothman", "given": "Kenneth J", "initials": "KJ", "orcid": "0000-0003-2398-1705", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60d1be3be5cd4d40a4bd796f7b5faed1.json"}}, {"family": "Di Federico", "given": "Silvia", "initials": "S"}, {"family": "Orsini", "given": "Nicola", "initials": "N", "orcid": "0000-0002-2210-5634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6161818f1f74a26883d3b1e37e72f2e.json"}}], "type": "journal article", "published": "2021-11-11", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "21", "issue": "1", "pages": "2069", "issn-l": null}, "abstract": "The relation between the magnitude of successive waves of the COVID-19 outbreak within the same communities could be useful in predicting the scope of new outbreaks.\n\nWe investigated the extent to which COVID-19 mortality in Italy during the second wave was related to first wave mortality within the same provinces. We compared data on province-specific COVID-19 2020 mortality in two time periods, corresponding to the first wave (February 24-June 30, 2020) and to the second wave (September 1-December 31, 2020), using cubic spline regression.\n\nFor provinces with the lowest crude mortality rate in the first wave (February-June), i.e. < 22 cases/100,000/month, mortality in the second wave (September-December) was positively associated with mortality during the first wave. In provinces with mortality greater than 22/100,000/month during the first wave, higher mortality in the first wave was associated with a lower second wave mortality. Results were similar when the analysis was censored at October 2020, before the implementation of region-specific measures against the outbreak. Neither vaccination nor variant spread had any role during the study period.\n\nThese findings indicate that provinces with the most severe initial COVID-19 outbreaks, as assessed through mortality data, faced milder second waves.", "doi": "10.1186/s12889-021-12126-4", "pmid": "34763690", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-12126-4"}, {"db": "pmc", "key": "PMC8582237"}], "notes": [], "created": "2021-11-26T15:15:22.465Z", "modified": "2021-11-26T15:15:22.635Z"}, {"entity": "publication", "iuid": "30a7a3647f8048f39edc4c8f51995693", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/30a7a3647f8048f39edc4c8f51995693.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/30a7a3647f8048f39edc4c8f51995693"}}, "title": "Does COVID-19 cause pre-eclampsia?", "authors": [{"family": "Khalil", "given": "A", "initials": "A", "orcid": "0000-0003-2802-7670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e4558e368114cfb83c4594f523b38c0.json"}}, {"family": "Samara", "given": "A", "initials": "A"}, {"family": "Chowdhury", "given": "T", "initials": "T"}, {"family": "O'Brien", "given": "P", "initials": "P"}], "type": "journal article", "published": "2021-11-11", "journal": {"title": "Ultrasound Obstet Gynecol", "issn": "1469-0705", "issn-l": null}, "abstract": null, "doi": "10.1002/uog.24809", "pmid": "34766403", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-11-26T15:14:32.705Z", "modified": "2021-11-26T15:14:32.763Z"}, {"entity": "publication", "iuid": "cf772b0823c44d21af699e5a1a2d38f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cf772b0823c44d21af699e5a1a2d38f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cf772b0823c44d21af699e5a1a2d38f2"}}, "title": "Conducting In-Depth Interviews via Mobile Phone with Persons with Common Mental Disorders and Multimorbidity: The Challenges and Advantages as Experienced by Participants and Researchers.", "authors": [{"family": "Azad", "given": "Azad\u00e9", "initials": "A"}, {"family": "Sernbo", "given": "Elisabet", "initials": "E"}, {"family": "Sv\u00e4rd", "given": "Veronica", "initials": "V", "orcid": "0000-0002-3868-0254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7ca2d10512349b99cee9e0f1c5dc274.json"}}, {"family": "Holmlund", "given": "Lisa", "initials": "L", "orcid": "0000-0001-8321-0174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53f74a6dae5e489782ca1566f3edea16.json"}}, {"family": "Bj\u00f6rk Br\u00e4mberg", "given": "Elisabeth", "initials": "E", "orcid": "0000-0002-0204-5144", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ecc3851dd7b44208efeea67732361a3.json"}}], "type": "journal article", "published": "2021-11-11", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "22", "issn-l": null}, "abstract": "Qualitative interviews are generally conducted in person. As the coronavirus pandemic (COVID-19) prevents in-person interviews, methodological studies which investigate the use of the telephone for persons with different illness experiences are needed. The aim was to explore experiences of the use of telephone during semi-structured research interviews, from the perspective of participants and researchers. Data were collected from mobile phone interviews with 32 individuals who had common mental disorders or multimorbidity which were analyzed thematically, as well as field notes reflecting researchers' experiences. The findings reveal several advantages of conducting interviews using mobile phones: flexibility, balanced anonymity and power relations, as well as a positive effect on self-disclosure and emotional display (leading to less emotional work and social responsibility). Challenges included the loss of human encounter, intense listening, and worries about technology, as well as sounds or disturbances in the environment. However, the positive aspects of not seeing each other were regarded as more important. In addition, we present some strategies before, during, and after conducting telephone interviews. Telephone interviews can be a valuable first option for data collection, allowing more individuals to be given a fair opportunity to share their experiences.", "doi": "10.3390/ijerph182211828", "pmid": "34831582", "labels": {"Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182211828"}, {"db": "pmc", "key": "PMC8619936"}], "notes": [], "created": "2021-12-18T18:16:12.225Z", "modified": "2021-12-18T18:16:12.357Z"}, {"entity": "publication", "iuid": "f49303d656f140cfa8c868576cd1316b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f49303d656f140cfa8c868576cd1316b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f49303d656f140cfa8c868576cd1316b"}}, "title": "Potential impact of the COVID-19 pandemic on the national and regional incidence, epidemiology and diagnostic testing of chlamydia and gonorrhoea in Sweden, 2020.", "authors": [{"family": "Saarentausta", "given": "Katariina", "initials": "K"}, {"family": "Ivarsson", "given": "Lovisa", "initials": "L"}, {"family": "Jacobsson", "given": "Susanne", "initials": "S"}, {"family": "Herrmann", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Sundqvist", "given": "Martin", "initials": "M"}, {"family": "Unemo", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-11-10", "journal": {"title": "APMIS", "issn": "1600-0463", "issn-l": null}, "abstract": "The COVID-19 pandemic has challenged the societies and health care systems globally, and resulted in many social and physical distancing restrictions to limit the spread of SARS-CoV-2. These restrictions have also likely affected the frequency of intimate contacts and the spread of sexually transmitted infections (STIs). Compared to most other countries, Sweden especially in Spring-Autumn 2020 pursued mainly milder voluntary, that is, not mandatory enforced by laws, recommended restrictions and the impacts of these on society and spread of STIs remain largely unknown. We describe the potential impact of the COVID-19 pandemic on the national and regional incidence, epidemiology and diagnostic testing of chlamydia and gonorrhoea in Sweden in 2020. Compared to 2019, we found a significant decrease in incidence of chlamydia (-4.5%) and gonorrhoea (-17.5%), and in diagnostic testing (-10.5% for chlamydia, -9.4% for gonorrhoea) in 2020. However, the decrease in chlamydia incidence, which has mainly been decreasing in the last 10 years, was not significant when compared with the average incidence in 2017-2019. The largest decrease in national incidence of both infections was observed among young and heterosexual patients, however, some Swedish regions showed an increased incidence, particularly of chlamydia. Increased \"internet-based self-sampling\" testing approach partly compensated for a decreased attendance at STI clinics. Studies, including sexual behaviour, prevention, reasons for attending STI health care, STIs in different anatomical sites and management of STIs, are required to elucidate the impact of COVID-19-associated social and physical distancing restrictions on sexual activity and the incidence and epidemiology of chlamydia and gonorrhoea in Sweden.", "doi": "10.1111/apm.13191", "pmid": "34758169", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T15:22:34.410Z", "modified": "2021-11-26T15:22:34.431Z"}, {"entity": "publication", "iuid": "53dd7dfa906448b1aea795e4962f0f89", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53dd7dfa906448b1aea795e4962f0f89.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53dd7dfa906448b1aea795e4962f0f89"}}, "title": "Impacts of mild and severe COVID-19 on sick leave.", "authors": [{"family": "Skyrud", "given": "Katrine", "initials": "K", "orcid": "0000-0001-7504-9253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa7b45c41c544ba098093febd55117c8.json"}}, {"family": "Telle", "given": "Kjetil", "initials": "K"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2021-11-10", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "issn-l": "0300-5771", "volume": "50", "issue": "5", "pages": "1745-1747"}, "abstract": null, "doi": "10.1093/ije/dyab182", "pmid": "34458903", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6359516"}, {"db": "pmc", "key": "PMC8499817"}], "notes": [], "created": "2021-09-01T07:47:46.351Z", "modified": "2021-11-18T13:50:25.240Z"}, {"entity": "publication", "iuid": "b272ffc2e1ba4ad9b0ea7696c08ed7bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b272ffc2e1ba4ad9b0ea7696c08ed7bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b272ffc2e1ba4ad9b0ea7696c08ed7bf"}}, "title": "From chaos to control - experiences of healthcare workers during the early phase of the COVID-19 pandemic: a focus group study.", "authors": [{"family": "R\u00fccker", "given": "Fredrik", "initials": "F"}, {"family": "H\u00e5rdstedt", "given": "Maria", "initials": "M"}, {"family": "R\u00fccker", "given": "Sekai Chenai Mathabire", "initials": "SCM"}, {"family": "Aspelin", "given": "Emma", "initials": "E"}, {"family": "Smirnoff", "given": "Alexander", "initials": "A"}, {"family": "Lindblom", "given": "Anders", "initials": "A"}, {"family": "Gustavsson", "given": "Catharina", "initials": "C", "orcid": "0000-0002-8709-4446", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ccad80107b2d47289e4a795a8dfb4a26.json"}}], "type": "journal article", "published": "2021-11-10", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "volume": "21", "issue": "1", "pages": "1219", "issn-l": null}, "abstract": "The Coronavirus disease 2019 (COVID-19) pandemic has caused overwhelming challenges to healthcare systems worldwide. Healthcare workers (HCWs) have faced particular challenges: being exposed to the coronavirus SARS-CoV-2 and caring for patients having a new and potentially life-threatening disease. The aim of this study was to explore how HCWs in the Swedish healthcare system perceived their work situation during the first phase of the COVID-19 pandemic in 2020.\n\nFocus group discussions and interviews with HCWs were performed from June to October 2020 in one Swedish healthcare region. A purposeful sampling approach was used to select a variety of professions (physicians, nurses, nurse aides and cleaners) and workplaces (hospital inpatient wards, emergency department, nursing home and home care service). Qualitative content analysis was used for data analysis.\n\nIn total, 51 HCWs participated in eight focus group discussions and one HCW participated in an individual interview. The content analysis identified two main categories: 'Concerns about the risk of infection and transmission of infection to others', and 'Transition from chaos to managing in a new and challenging work situation'. The findings revealed how HCWs perceived working conditions, including experiences of fear for personal health, confusion and uncertainty regarding personal protective equipment and infection prevention and control (PPE/IPC), and fear of infecting others. Both fearful and appreciating attitudes were achieved from the surrounding community. Helpful strategies for transition from chaos to control were lifted i.e. present and supportive leadership, and finding comfort and strength in the working team. Both helplessness and meaningfulness were described when caring for COVID-19 patients.\n\nThis study provides unique insights into HCWs experiences of an extremely challenging work situation during the first phase of the COVID-19 pandemic, including feelings of stress and insecurity in a chaotic and hazardous working environment. But there is also mitigation of these challenges and even positive experiences including feelings of safety and meaningfulness. To enhance safety among HCWs in healthcare crises such as the COVID-19 pandemic, the findings highlight the importance of avoiding confusion about PPE/IPC, having a supportive healthcare leadership and ensuring accurate information provision about virus transmission to the public.", "doi": "10.1186/s12913-021-07248-9", "pmid": "34758837", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-021-07248-9"}, {"db": "pmc", "key": "PMC8579171"}], "notes": [], "created": "2021-11-26T15:22:04.914Z", "modified": "2021-11-26T15:22:04.968Z"}, {"entity": "publication", "iuid": "c1a3fc23659846ab983c7656417045fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1a3fc23659846ab983c7656417045fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1a3fc23659846ab983c7656417045fc"}}, "title": "Fear of COVID-19 lead to procrastination among Turkish university students: The mediating role of intolerance of uncertainty.", "authors": [{"family": "Do\u011fan\u00fclk\u00fc", "given": "Hac\u0131 Arif", "initials": "HA"}, {"family": "Korkmaz", "given": "Ozan", "initials": "O"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-11-10", "journal": {"title": "BMC Psychol", "issn": "2050-7283", "volume": "9", "issue": "1", "pages": "178", "issn-l": null}, "abstract": "The COVID-19 outbreak has not only increased mortality but has also negatively affected mental health among populations across the world. Furthermore, individuals are experiencing uncertainty about their current and future situation because of the pandemic. Therefore, the present study investigated the mediating role of intolerance of uncertainty in the relationship between fear of COVID-19 and procrastination among a sample of Turkish university students.\n\nBetween October and November 2020, 450 university students (291 females and 159 males aged 17 to 24 years) from three state universities in Turkey completed an online survey. Correlation analysis and structural equation modeling methods were employed to examine a model for understanding the general procrastination during COVID-19 pandemic.\n\nThe results of the correlation analysis indicated that the fear of COVID-19 was positively correlated with both intolerance of uncertainty (r = .26, p < .001) and procrastination (r = .23, p < .001). The mediation analysis also showed that intolerance of uncertainty had a significant mediating role in the relationship between fear of COVID-19 and procrastination (\u03b2 = .11, p < .001).\n\nReducing the fear of COVID-19 and intolerance of uncertainty is likely to contribute to reducing individuals' procrastination behaviors during the pandemic.", "doi": "10.1186/s40359-021-00681-9", "pmid": "34758865", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s40359-021-00681-9"}, {"db": "pmc", "key": "PMC8579725"}], "notes": [], "created": "2021-11-26T15:21:49.770Z", "modified": "2021-11-26T15:21:49.804Z"}, {"entity": "publication", "iuid": "82f55ec89a3747aaa9cc0ee95306a936", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82f55ec89a3747aaa9cc0ee95306a936.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82f55ec89a3747aaa9cc0ee95306a936"}}, "title": "Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trial.", "authors": [{"family": "Granholm", "given": "Anders", "initials": "A", "orcid": "0000-0001-5799-7655", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d058ecb91d4c482abbee511b044ddf75.json"}}, {"family": "Munch", "given": "Marie Warrer", "initials": "MW"}, {"family": "Myatra", "given": "Sheila Nainan", "initials": "SN"}, {"family": "Vijayaraghavan", "given": "Bharath Kumar Tirupakuzhi", "initials": "BKT"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Wahlin", "given": "Rebecka Rubenson", "initials": "RR"}, {"family": "Jakob", "given": "Stephan M", "initials": "SM"}, {"family": "Cioccari", "given": "Luca", "initials": "L"}, {"family": "Kj\u00e6r", "given": "Maj-Brit N\u00f8rregaard", "initials": "MN"}, {"family": "Vesterlund", "given": "Gitte Kingo", "initials": "GK"}, {"family": "Meyhoff", "given": "Tine Sylvest", "initials": "TS"}, {"family": "Helleberg", "given": "Marie", "initials": "M"}, {"family": "M\u00f8ller", "given": "Morten Hylander", "initials": "MH"}, {"family": "Benfield", "given": "Thomas", "initials": "T"}, {"family": "Venkatesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Hammond", "given": "Naomi E", "initials": "NE"}, {"family": "Micallef", "given": "Sharon", "initials": "S"}, {"family": "Bassi", "given": "Abhinav", "initials": "A"}, {"family": "John", "given": "Oommen", "initials": "O"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Kristiansen", "given": "Klaus Tjelle", "initials": "KT"}, {"family": "Ulrik", "given": "Charlotte Suppli", "initials": "CS"}, {"family": "J\u00f8rgensen", "given": "Vibeke Lind", "initials": "VL"}, {"family": "Smitt", "given": "Margit", "initials": "M"}, {"family": "Bestle", "given": "Morten H", "initials": "MH"}, {"family": "Andreasen", "given": "Anne Sofie", "initials": "AS"}, {"family": "Poulsen", "given": "Lone Musaeus", "initials": "LM"}, {"family": "Rasmussen", "given": "Bodil Steen", "initials": "BS"}, {"family": "Br\u00f8chner", "given": "Anne Craveiro", "initials": "AC"}, {"family": "Str\u00f8m", "given": "Thomas", "initials": "T"}, {"family": "M\u00f8ller", "given": "Anders", "initials": "A"}, {"family": "Khan", "given": "Mohd Saif", "initials": "MS"}, {"family": "Padmanaban", "given": "Ajay", "initials": "A"}, {"family": "Divatia", "given": "Jigeeshu Vasishtha", "initials": "JV"}, {"family": "Saseedharan", "given": "Sanjith", "initials": "S"}, {"family": "Borawake", "given": "Kapil", "initials": "K"}, {"family": "Kapadia", "given": "Farhad", "initials": "F"}, {"family": "Dixit", "given": "Subhal", "initials": "S"}, {"family": "Chawla", "given": "Rajesh", "initials": "R"}, {"family": "Shukla", "given": "Urvi", "initials": "U"}, {"family": "Amin", "given": "Pravin", "initials": "P"}, {"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Wamberg", "given": "Christian Aage", "initials": "CA"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Lange", "given": "Theis", "initials": "T"}, {"family": "Perner", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-11-10", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "issn-l": "0342-4642"}, "abstract": "We compared dexamethasone 12 versus 6 mg daily for up to 10 days in patients with coronavirus disease 2019 (COVID-19) and severe hypoxaemia in the international, randomised, blinded COVID STEROID 2 trial. In the primary, conventional analyses, the predefined statistical significance thresholds were not reached. We conducted a pre-planned Bayesian analysis to facilitate probabilistic interpretation.\n\nWe analysed outcome data within 90 days in the intention-to-treat population (data available in 967 to 982 patients) using Bayesian models with various sensitivity analyses. Results are presented as median posterior probabilities with 95% credible intervals (CrIs) and probabilities of different effect sizes with 12 mg dexamethasone.\n\nThe adjusted mean difference on days alive without life support at day 28 (primary outcome) was 1.3 days (95% CrI -0.3 to 2.9; 94.2% probability of benefit). Adjusted relative risks and probabilities of benefit on serious adverse reactions was 0.85 (0.63 to 1.16; 84.1%) and on mortality 0.87 (0.73 to 1.03; 94.8%) at day 28 and 0.88 (0.75 to 1.02; 95.1%) at day 90. Probabilities of benefit on days alive without life support and days alive out of hospital at day 90 were 85 and 95.7%, respectively. Results were largely consistent across sensitivity analyses, with relatively low probabilities of clinically important harm with 12 mg on all outcomes in all analyses.\n\nWe found high probabilities of benefit and low probabilities of clinically important harm with dexamethasone 12 mg versus 6 mg daily in patients with COVID-19 and severe hypoxaemia on all outcomes up to 90 days.", "doi": "10.1007/s00134-021-06573-1", "pmid": "34757439", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-021-06573-1"}, {"db": "pmc", "key": "PMC8579417"}, {"db": "ClinicalTrials.gov", "key": "NCT04509973"}, {"db": "CTRI", "key": "CTRI/2020/10/028731"}], "notes": [], "created": "2021-11-26T15:22:50.796Z", "modified": "2021-11-26T15:22:50.839Z"}, {"entity": "publication", "iuid": "44db6ce5a85b416fb6d9dbeff3b0ba79", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44db6ce5a85b416fb6d9dbeff3b0ba79.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44db6ce5a85b416fb6d9dbeff3b0ba79"}}, "title": "Crosstalk between the renin-angiotensin, complement and kallikrein-kinin systems in inflammation.", "authors": [{"family": "Bekassy", "given": "Zivile", "initials": "Z", "orcid": "0000-0002-5942-281X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/66f1635f53944e9b9bea08d62caa4f17.json"}}, {"family": "Lopatko Fagerstr\u00f6m", "given": "Ingrid", "initials": "I"}, {"family": "Bader", "given": "Michael", "initials": "M"}, {"family": "Karpman", "given": "Diana", "initials": "D", "orcid": "0000-0001-7220-7658", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a7a12da87fb48359206955185eb7b4e.json"}}], "type": "journal article", "published": "2021-11-10", "journal": {"title": "Nat Rev Immunol", "issn": "1474-1741", "issn-l": "1474-1733"}, "abstract": "During severe inflammatory and infectious diseases, various mediators modulate the equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review describes the interactive roles of the renin-angiotensin system, the complement system, and the closely linked kallikrein-kinin and contact systems in cell biological functions such as vascular tone and leakage, inflammation, chemotaxis, thrombosis and cell proliferation. Specific attention is given to the role of these systems in systemic inflammation in the vasculature and tissues during hereditary angioedema, cardiovascular and renal glomerular disease, vasculitides and COVID-19. Moreover, we discuss the therapeutic implications of these complex interactions, given that modulation of one system may affect the other systems, with beneficial or deleterious consequences.", "doi": "10.1038/s41577-021-00634-8", "pmid": "34759348", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41577-021-00634-8"}, {"db": "pmc", "key": "PMC8579187"}], "notes": [], "created": "2021-11-26T15:21:35.598Z", "modified": "2021-11-26T15:21:35.698Z"}, {"entity": "publication", "iuid": "64996e79702540a8a8c5a5ec12612391", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/64996e79702540a8a8c5a5ec12612391.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/64996e79702540a8a8c5a5ec12612391"}}, "title": "Prevalence of Gastrointestinal Symptoms in Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Results of the Prospective Controlled Multinational GI-COVID-19 Study.", "authors": [{"family": "Marasco", "given": "Giovanni", "initials": "G"}, {"family": "Cremon", "given": "Cesare", "initials": "C"}, {"family": "Barbaro", "given": "Maria Raffaella", "initials": "MR"}, {"family": "Salvi", "given": "Daniele", "initials": "D"}, {"family": "Cacciari", "given": "Giulia", "initials": "G"}, {"family": "Kagramanova", "given": "Anna", "initials": "A"}, {"family": "Bordin", "given": "Dmitry", "initials": "D"}, {"family": "Drug", "given": "Vasile", "initials": "V"}, {"family": "Miftode", "given": "Edgidia", "initials": "E"}, {"family": "Fusaroli", "given": "Pietro", "initials": "P"}, {"family": "Mohamed", "given": "Salem Youssef", "initials": "SY"}, {"family": "Ricci", "given": "Chiara", "initials": "C"}, {"family": "Bellini", "given": "Massimo", "initials": "M"}, {"family": "Rahman", "given": "M Masudur", "initials": "MM"}, {"family": "Melcarne", "given": "Luigi", "initials": "L"}, {"family": "Santos", "given": "Javier", "initials": "J"}, {"family": "Lobo", "given": "Beatriz", "initials": "B"}, {"family": "Bor", "given": "Serhat", "initials": "S"}, {"family": "Yapali", "given": "Suna", "initials": "S"}, {"family": "Akyol", "given": "Deniz", "initials": "D"}, {"family": "Sapmaz", "given": "Ferdane Pirincci", "initials": "FP"}, {"family": "Urun", "given": "Yonca Yilmaz", "initials": "YY"}, {"family": "Eskazan", "given": "Tugce", "initials": "T"}, {"family": "Celebi", "given": "Altay", "initials": "A"}, {"family": "Kacmaz", "given": "Huseyin", "initials": "H"}, {"family": "Ebik", "given": "Berat", "initials": "B"}, {"family": "Binicier", "given": "Hatice Cilem", "initials": "HC"}, {"family": "Bugdayci", "given": "Mehmet Sait", "initials": "MS"}, {"family": "Ya\u011fc\u0131", "given": "Munkhtsetseg Banzragch", "initials": "MB"}, {"family": "Pullukcu", "given": "Husnu", "initials": "H"}, {"family": "Kaya", "given": "Berrin Yal\u0131nbas", "initials": "BY"}, {"family": "Tureyen", "given": "Ali", "initials": "A"}, {"family": "Hatemi", "given": "\u0130brahim", "initials": "\u0130"}, {"family": "Koc", "given": "Elif Sitre", "initials": "ES"}, {"family": "Sirin", "given": "Goktug", "initials": "G"}, {"family": "Cal\u0131skan", "given": "Ali Riza", "initials": "AR"}, {"family": "Bengi", "given": "Goksel", "initials": "G"}, {"family": "Al\u0131s", "given": "Esra Ergun", "initials": "EE"}, {"family": "Lukic", "given": "Snezana", "initials": "S"}, {"family": "Trajkovska", "given": "Meri", "initials": "M"}, {"family": "Hod", "given": "Keren", "initials": "K"}, {"family": "Dumitrascu", "given": "Dan", "initials": "D"}, {"family": "Pietrangelo", "given": "Antonello", "initials": "A"}, {"family": "Corradini", "given": "Elena", "initials": "E"}, {"family": "Simren", "given": "Magnus", "initials": "M"}, {"family": "Sjolund", "given": "Jessica", "initials": "J"}, {"family": "Tornkvist", "given": "Navkiran", "initials": "N"}, {"family": "Ghoshal", "given": "Uday C", "initials": "UC"}, {"family": "Kolokolnikova", "given": "Olga", "initials": "O"}, {"family": "Colecchia", "given": "Antonio", "initials": "A"}, {"family": "Serra", "given": "Jordi", "initials": "J"}, {"family": "Maconi", "given": "Giovanni", "initials": "G"}, {"family": "De Giorgio", "given": "Roberto", "initials": "R"}, {"family": "Danese", "given": "Silvio", "initials": "S"}, {"family": "Portincasa", "given": "Pietro", "initials": "P"}, {"family": "Di Stefano", "given": "Michele", "initials": "M"}, {"family": "Maggio", "given": "Marcello", "initials": "M"}, {"family": "Philippou", "given": "Elena", "initials": "E"}, {"family": "Lee", "given": "Yeong Yeh", "initials": "YY"}, {"family": "Venturi", "given": "Alessandro", "initials": "A"}, {"family": "Borghi", "given": "Claudio", "initials": "C"}, {"family": "Zoli", "given": "Marco", "initials": "M"}, {"family": "Gionchetti", "given": "Paolo", "initials": "P"}, {"family": "Viale", "given": "Pierluigi", "initials": "P"}, {"family": "Stanghellini", "given": "Vincenzo", "initials": "V"}, {"family": "Barbara", "given": "Giovanni", "initials": "G"}, {"family": "and the GI-COVID19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-09", "journal": {"title": "Am J Gastroenterol", "issn": "1572-0241", "issn-l": null}, "abstract": "Gastrointestinal (GI) symptoms in coronavirus-19 disease (COVID-19) have been reported with great variability and without standardization. In hospitalized patients, we aimed to evaluate the prevalence of GI symptoms, factors associated with their occurrence, and variation at 1 month.\n\nThe GI-COVID-19 is a prospective, multicenter, controlled study. Patients with and without COVID-19 diagnosis were recruited at hospital admission and asked for GI symptoms at admission and after 1 month, using the validated Gastrointestinal Symptom Rating Scale questionnaire.\n\nThe study included 2036 hospitalized patients. A total of 871 patients (575 COVID+ and 296 COVID-) were included for the primary analysis. GI symptoms occurred more frequently in patients with COVID-19 (59.7%; 343/575 patients) than in the control group (43.2%; 128/296 patients) (P < 0.001). Patients with COVID-19 complained of higher presence or intensity of nausea, diarrhea, loose stools, and urgency as compared with controls. At a 1-month follow-up, a reduction in the presence or intensity of GI symptoms was found in COVID-19 patients with GI symptoms at hospital admission. Nausea remained increased over controls. Factors significantly associated with nausea persistence in COVID-19 were female sex, high body mass index, the presence of dyspnea, and increased C-reactive protein levels.\n\nThe prevalence of GI symptoms in hospitalized patients with COVID-19 is higher than previously reported. Systemic and respiratory symptoms are often associated with GI complaints. Nausea may persist after the resolution of COVID-19 infection.", "doi": "10.14309/ajg.0000000000001541", "pmid": "34751672", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00000434-990000000-00142"}, {"db": "ClinicalTrials.gov", "key": "NCT04691895"}], "notes": [], "created": "2021-11-26T15:24:24.070Z", "modified": "2021-11-26T15:24:24.106Z"}, {"entity": "publication", "iuid": "2b4e6205c4f342c4805d41dd1d723a40", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b4e6205c4f342c4805d41dd1d723a40.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b4e6205c4f342c4805d41dd1d723a40"}}, "title": "Length of hospital stay and risk of intensive care admission and in-hospital death among COVID-19 patients in Norway: a register-based cohort study comparing patients fully vaccinated with an mRNA vaccine to unvaccinated patients", "authors": [{"family": "Whittaker", "given": "Robert", "initials": "R"}, {"family": "Br\u00e5then Kristofferson", "given": "Anja", "initials": "A"}, {"family": "Valcarcel Salamanca", "given": "Beatriz", "initials": "B"}, {"family": "Sepp\u00e4l\u00e4", "given": "Elina", "initials": "E"}, {"family": "Golestani", "given": "Karan", "initials": "K"}, {"family": "Kv\u00e5le", "given": "Reidar", "initials": "R"}, {"family": "Watle", "given": "Sara Viksmoen", "initials": "SV"}, {"family": "Buanes", "given": "Eirik Alnes", "initials": "EA"}], "type": "posted-content", "published": "2021-11-09", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.11.05.21265958", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:44:50.667Z", "modified": "2022-01-04T15:44:50.668Z"}, {"entity": "publication", "iuid": "93e4da7e9f8943779eb12a1d7d20110e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/93e4da7e9f8943779eb12a1d7d20110e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/93e4da7e9f8943779eb12a1d7d20110e"}}, "title": "COVID-19: What have we learned? What are the public health challenges?", "authors": [{"family": "Zeegers Paget", "given": "Dineke", "initials": "D"}, {"family": "Allebeck", "given": "Peter", "initials": "P", "orcid": "0000-0002-2778-6467", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de9f0e1c3e4d402b93e61ad1c5a771fb.json"}}, {"family": "Nagyova", "given": "Iveta", "initials": "I"}], "type": "journal-article", "published": "2021-11-09", "journal": {"title": "Eur J Public Health", "issn": "1101-1262", "volume": "31", "issue": "Supplement_4", "pages": "iv1-iv2", "issn-l": null}, "abstract": null, "doi": "10.1093/eurpub/ckab150", "pmid": "34751364", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8576293"}, {"db": "pii", "key": "6423460"}], "notes": [], "created": "2021-11-26T15:24:39.334Z", "modified": "2023-06-19T07:31:51.619Z"}, {"entity": "publication", "iuid": "acb1627ba8ce46d6923061af7507618b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/acb1627ba8ce46d6923061af7507618b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/acb1627ba8ce46d6923061af7507618b"}}, "title": "Advancing African Medicines Agency through Global Health Diplomacy for an Equitable Pan-African Universal Health Coverage: A Scoping Review.", "authors": [{"family": "Chattu", "given": "Vijay Kumar", "initials": "VK", "orcid": "0000-0001-9840-8335", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cebeeb53463e436e9ce1ffc57ec4a9b4.json"}}, {"family": "Dave", "given": "Vishal B", "initials": "VB", "orcid": "0000-0001-8099-1569", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0606a7312b9843c6ac11ba4e7440adc9.json"}}, {"family": "Reddy", "given": "K Srikanth", "initials": "KS"}, {"family": "Singh", "given": "Bawa", "initials": "B"}, {"family": "Sahiledengle", "given": "Biniyam", "initials": "B", "orcid": "0000-0002-1114-4849", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c434b82648f4f4c96d13e82c4a61ae1.json"}}, {"family": "Heyi", "given": "Demisu Zenbaba", "initials": "DZ"}, {"family": "Nattey", "given": "Cornelius", "initials": "C"}, {"family": "Atlaw", "given": "Daniel", "initials": "D", "orcid": "0000-0002-2968-4958", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f44d2cf7abb4db4affc9bad0e273cc7.json"}}, {"family": "Jackson", "given": "Kioko", "initials": "K"}, {"family": "El-Khatib", "given": "Ziad", "initials": "Z", "orcid": "0000-0003-0756-7280", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31747e0476314de9bf53d8c8f3d1d147.json"}}, {"family": "Eltom", "given": "Akram Ali", "initials": "AA"}], "type": "journal article", "published": "2021-11-09", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "22", "pages": null}, "abstract": "The African continent is home to 15% of the world's population and suffers from a disease burden of more than 25% globally. In this COVID-19 era, the high burden and mortality are further worsened due to inequities, inequalities such as inadequate health systems, scarce financial and human resources, as well as unavailability of inexpensive medicines of good quality, safety, and efficacy. The Universal Health Coverage ensures that people have access to high-quality essential health services, secure, reliable, and affordable essential medicines and vaccines, as well as financial security. This paper aimed at addressing the critical need for a continental African Medicines Agency (AMA) in addressing the inequities and the role of global health diplomacy in building consensus to support the ratification of the Treaty of AMA. A literature review was done in Scopus, Web of Science, MEDLINE/PubMed, and Google Scholar search engine to identify the critical literature in the context of study objectives. All the articles published after 2015 till 2021 in the context of AMA were included. African Health Strategy 2016-2030 highlighted the importance of an African regulatory mechanism for medicines and medical products. Through global health diplomacy (GHD), the African Union and its partners can negotiate and cooperate in providing infrastructural, administrative, and regulatory support for establishing the AMA. The paper emphasizes the South-South cooperation and highlights the contributions of India and China in the supply of medicines and vaccines to Africa. A strong AMA created through GHD can be a vital instrument in utilizing Trade-Related Aspects of Intellectual Property Rights (TRIPS) flexibilities extension and an ideal partner for European and other regional regulatory authorities seeking to stem the tide of counterfeit, sub-standard, or fake products.", "doi": "10.3390/ijerph182211758", "pmid": "34831511", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph182211758"}, {"db": "pmc", "key": "PMC8621302"}], "notes": [], "created": "2021-12-18T18:16:31.169Z", "modified": "2021-12-18T18:16:59.133Z"}, {"entity": "publication", "iuid": "210b5b5071e9404daef80cc8c61a3440", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/210b5b5071e9404daef80cc8c61a3440.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/210b5b5071e9404daef80cc8c61a3440"}}, "title": "Rapid and sensitive detection of SARS-CoV-2 infection using quantitative peptide enrichment LC-MS analysis.", "authors": [{"family": "Hober", "given": "Andreas", "initials": "A", "orcid": "0000-0001-8947-2562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20274f9e591044c1936d134df8a1950d.json"}}, {"family": "Tran-Minh", "given": "Khue Hua", "initials": "KH"}, {"family": "Foley", "given": "Dominic", "initials": "D"}, {"family": "McDonald", "given": "Thomas", "initials": "T"}, {"family": "Vissers", "given": "Johannes Pc", "initials": "JP"}, {"family": "Pattison", "given": "Rebecca", "initials": "R"}, {"family": "Ferries", "given": "Samantha", "initials": "S"}, {"family": "Hermansson", "given": "Sigurd", "initials": "S"}, {"family": "Betner", "given": "Ingvar", "initials": "I"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M"}, {"family": "Razavi", "given": "Morteza", "initials": "M"}, {"family": "Yip", "given": "Richard", "initials": "R"}, {"family": "Pope", "given": "Matthew E", "initials": "ME"}, {"family": "Pearson", "given": "Terry W", "initials": "TW"}, {"family": "Andersson", "given": "Leigh N", "initials": "LN"}, {"family": "Bartlett", "given": "Amy", "initials": "A"}, {"family": "Calton", "given": "Lisa", "initials": "L"}, {"family": "Alm", "given": "Jessica J", "initials": "JJ"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Edfors", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-0017-7987", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1908b42d06b74ee99706fb235d4bda90.json"}}], "type": "journal article", "published": "2021-11-08", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "10", "issn-l": null}, "abstract": "Reliable, robust, large-scale molecular testing for SARS-CoV-2 is essential for monitoring the ongoing Covid-19 pandemic. We have developed a scalable analytical approach to detect viral proteins based on peptide immunoaffinity enrichment combined with liquid chromatography - mass spectrometry (LC-MS). This is a multiplexed strategy, based on targeted proteomics analysis and read-out by LC-MS, capable of precisely quantifying and confirming the presence of SARS-CoV-2 in PBS swab media from combined throat/nasopharynx/saliva samples.<br />The results reveal that the levels of SARS-CoV-2 measured by LC-MS correlate well with their corresponding RT-PCR readout (r=0.79). The analytical workflow shows similar turnaround times as regular RT-PCR instrumentation with a quantitative readout of viral proteins corresponding to cycle thresholds (Ct) equivalents ranging from 21 to 34. Using RT-PCR as a reference, we demonstrate that the LC-MS-based method has 100% negative percent agreement (estimated specificity) and 95% positive percent agreement (estimated sensitivity) when analyzing clinical samples collected from asymptomatic individuals with a Ct within the limit of detection of the mass spectrometer (Ct \u226430). These results suggest that a scalable analytical method based on LC-MS has a place in future pandemic preparedness centers to complement current virus detection technologies.", "doi": "10.7554/eLife.70843", "pmid": "34747696", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "70843"}, {"db": "URL", "key": "http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD026366", "description": "PXD026366"}, {"db": "URL", "key": "https://panoramaweb.org/sars-cov-2_siscapa.url", "description": "https://panoramaweb.org/sars-cov-2_siscapa.url"}], "notes": [], "created": "2021-11-26T15:26:16.157Z", "modified": "2021-11-26T15:29:02.059Z"}, {"entity": "publication", "iuid": "07d46c6a5c20498da11b302b3193ee2c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07d46c6a5c20498da11b302b3193ee2c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07d46c6a5c20498da11b302b3193ee2c"}}, "title": "Poor outcome of patients with COVID-19 after CAR T-cell therapy for B-cell malignancies: results of a multicenter study on behalf of the European Society for Blood and Marrow Transplantation (EBMT) Infectious Diseases Working Party and the European Hematology Association (EHA) Lymphoma Group.", "authors": [{"family": "Spanjaart", "given": "Anne Mea", "initials": "AM"}, {"family": "Ljungman", "given": "Per", "initials": "P", "orcid": "0000-0002-8281-3245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4546eb504184683ab712eee858ea9cb.json"}}, {"family": "de La Camara", "given": "Rafael", "initials": "R", "orcid": "0000-0002-8189-5779", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/868bc0284ac640a1bf215e7d7cc86da3.json"}}, {"family": "Tridello", "given": "Gloria", "initials": "G"}, {"family": "Ortiz-Maldonado", "given": "Valent\u00edn", "initials": "V"}, {"family": "Urbano-Ispizua", "given": "Alvaro", "initials": "A"}, {"family": "Barba", "given": "Pere", "initials": "P", "orcid": "0000-0003-1038-5197", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e74c0f29540e4f59aa53f83fec63148f.json"}}, {"family": "Kwon", "given": "Mi", "initials": "M", "orcid": "0000-0002-3855-7774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04365251372d4a07bc1f72e2aaa487d1.json"}}, {"family": "Caballero", "given": "Dolores", "initials": "D"}, {"family": "Sesques", "given": "Pierre", "initials": "P"}, {"family": "Bachy", "given": "Emmanuel", "initials": "E"}, {"family": "Di Blasi", "given": "Roberta", "initials": "R"}, {"family": "Thieblemont", "given": "Catherine", "initials": "C"}, {"family": "Calkoen", "given": "Friso", "initials": "F", "orcid": "0000-0001-9059-0929", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3922445905394bcc810e480b12115a2c.json"}}, {"family": "Mutsaers", "given": "Pim", "initials": "P", "orcid": "0000-0002-3924-8578", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/abf9518b9408436ea710a959f84412af.json"}}, {"family": "Maertens", "given": "Johan", "initials": "J", "orcid": "0000-0003-4257-5980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4701b45871ba4030a2c57c01edcbf6e0.json"}}, {"family": "Giannoni", "given": "Livia", "initials": "L"}, {"family": "Nicholson", "given": "Emma", "initials": "E"}, {"family": "Collin", "given": "Matthew", "initials": "M", "orcid": "0000-0001-6585-9586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28e509d4da164f1d95963e649a3a6d78.json"}}, {"family": "Vaz", "given": "Carlos Pinho", "initials": "CP"}, {"family": "Metafuni", "given": "Elisabetta", "initials": "E"}, {"family": "Martinez-Lopez", "given": "Joaquin", "initials": "J"}, {"family": "Dignan", "given": "Fiona L", "initials": "FL"}, {"family": "Ribera", "given": "Josep-Maria", "initials": "JM"}, {"family": "Nagler", "given": "Arnon", "initials": "A"}, {"family": "Folber", "given": "Frantisek", "initials": "F"}, {"family": "Sanderson", "given": "Robin", "initials": "R"}, {"family": "Bloor", "given": "Adrian", "initials": "A", "orcid": "0000-0003-4550-220X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48157ff9b02f48b1878d9fea89853d4c.json"}}, {"family": "Ciceri", "given": "Fabio", "initials": "F"}, {"family": "Knelange", "given": "Nina", "initials": "N"}, {"family": "Ayuk", "given": "Francis", "initials": "F"}, {"family": "Kroger", "given": "Nicolaus", "initials": "N"}, {"family": "Kersten", "given": "Marie Jos\u00e9", "initials": "MJ"}, {"family": "Mielke", "given": "Stephan", "initials": "S", "orcid": "0000-0003-0167-6021", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b98a5979f3d4471bbbed5f392c31d1ce.json"}}], "type": "journal article", "published": "2021-11-08", "journal": {"title": "Leukemia", "issn": "1476-5551", "issn-l": null}, "abstract": null, "doi": "10.1038/s41375-021-01466-0", "pmid": "34750508", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41375-021-01466-0"}, {"db": "pmc", "key": "PMC8573311"}], "notes": [], "created": "2021-11-26T15:25:32.981Z", "modified": "2021-11-26T15:25:33.293Z"}, {"entity": "publication", "iuid": "2414e9421be64e729b4ecf0ff54aa539", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2414e9421be64e729b4ecf0ff54aa539.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2414e9421be64e729b4ecf0ff54aa539"}}, "title": "How an outbreak became a pandemic: a chronological analysis of crucial junctures and international obligations in the early months of the COVID-19 pandemic.", "authors": [{"family": "Singh", "given": "Sudhvir", "initials": "S"}, {"family": "McNab", "given": "Christine", "initials": "C"}, {"family": "Olson", "given": "Rose McKeon", "initials": "RM"}, {"family": "Bristol", "given": "Nellie", "initials": "N"}, {"family": "Nolan", "given": "Cody", "initials": "C"}, {"family": "Bergstr\u00f8m", "given": "Elin", "initials": "E"}, {"family": "Bartos", "given": "Michael", "initials": "M"}, {"family": "Mabuchi", "given": "Shunsuke", "initials": "S"}, {"family": "Panjabi", "given": "Raj", "initials": "R"}, {"family": "Karan", "given": "Abraar", "initials": "A"}, {"family": "Abdalla", "given": "Salma M", "initials": "SM"}, {"family": "Bonk", "given": "Mathias", "initials": "M"}, {"family": "Jamieson", "given": "Margaret", "initials": "M"}, {"family": "Werner", "given": "George K", "initials": "GK"}, {"family": "Nordstr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Legido-Quigley", "given": "Helena", "initials": "H"}, {"family": "Phelan", "given": "Alexandra", "initials": "A"}], "type": "journal article", "published": "2021-11-08", "journal": {"title": "Lancet", "issn": "1474-547X", "issn-l": "0140-6736"}, "abstract": "Understanding the spread of SARS-CoV-2, how and when evidence emerged, and the timing of local, national, regional, and global responses is essential to establish how an outbreak became a pandemic and to prepare for future health threats. With that aim, the Independent Panel for Pandemic Preparedness and Response has developed a chronology of events, actions, and recommendations, from December, 2019, when the first cases of COVID-19 were identified in China, to the end of March, 2020, by which time the outbreak had spread extensively worldwide and had been characterised as a pandemic. Datapoints are based on two literature reviews, WHO documents and correspondence, submissions to the Panel, and an expert verification process. The retrospective analysis of the chronology shows a dedicated initial response by WHO and some national governments, but also aspects of the response that could have been quicker, including outbreak notifications under the International Health Regulations (IHR), presumption and confirmation of human-to-human transmission of SARS-CoV-2, declaration of a Public Health Emergency of International Concern, and, most importantly, the public health response of many national governments. The chronology also shows that some countries, largely those with previous experience with similar outbreaks, reacted quickly, even ahead of WHO alerts, and were more successful in initially containing the virus. Mapping actions against IHR obligations, the chronology shows where efficiency and accountability could be improved at local, national, and international levels to more quickly alert and contain health threats in the future. In particular, these improvements include necessary reforms to international law and governance for pandemic preparedness and response, including the IHR and a potential framework convention on pandemic preparedness and response.", "doi": "10.1016/S0140-6736(21)01897-3", "pmid": "34762857", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)01897-3"}, {"db": "pmc", "key": "PMC8575464"}], "notes": [], "created": "2021-11-26T15:16:22.583Z", "modified": "2021-11-26T15:16:48.040Z"}, {"entity": "publication", "iuid": "26a045fa28384ae5abc4f75b80218a65", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26a045fa28384ae5abc4f75b80218a65.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26a045fa28384ae5abc4f75b80218a65"}}, "title": "COVID-19 and CAR-T cells: current challenges and future directions-a report from the EPICOVIDEHA survey by EHA-IDWP.", "authors": [{"family": "Busca", "given": "Alessandro", "initials": "A"}, {"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J", "orcid": "0000-0002-6766-8297", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dea501020d2042ad83d1b024987792f4.json"}}, {"family": "Corradini", "given": "Paolo", "initials": "P", "orcid": "0000-0002-9186-1353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d0e56ba864949b68f35a952b7d18036.json"}}, {"family": "Marchesi", "given": "Francesco", "initials": "F"}, {"family": "Cabirta", "given": "Alba", "initials": "A", "orcid": "0000-0001-7198-8894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ca8361c64eb4563a0f090faaf569e8a.json"}}, {"family": "Di Blasi", "given": "Roberta", "initials": "R", "orcid": "0000-0001-9001-573X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b0e256f42ad4d25aef901a2c2df7eab.json"}}, {"family": "Dulery", "given": "Remy", "initials": "R", "orcid": "0000-0002-5024-1713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e911a2d994434edbb736f77b7ccfcd72.json"}}, {"family": "Lamure", "given": "Sylvain", "initials": "S", "orcid": "0000-0001-5980-305X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0dc734a9a9e4016b2a1699809823fe2.json"}}, {"family": "Farina", "given": "Francesca", "initials": "F"}, {"family": "Weinbergerov\u00e1", "given": "Barbora", "initials": "B", "orcid": "0000-0001-6460-2471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7ef50b8f8dc457ab2badd8481b3fa86.json"}}, {"family": "Batini\u0107", "given": "Josip", "initials": "J"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Lopez-Garcia", "given": "Alberto", "initials": "A", "orcid": "0000-0002-5354-5261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c785356a67e4cbb9835fe9ce04a6153.json"}}, {"family": "Drgona", "given": "Lubos", "initials": "L", "orcid": "0000-0002-5089-3201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/746b17dbdf2a4b178e6a11454778c725.json"}}, {"family": "Espigado", "given": "Ildefonso", "initials": "I", "orcid": "0000-0002-4043-6613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40c943f7cd0e40998a4a1ae519a39e48.json"}}, {"family": "Falces-Romero", "given": "Iker", "initials": "I"}, {"family": "Garcia-Sanz", "given": "Ramon", "initials": "R", "orcid": "0000-0003-4120-2787", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8823f2241b74c59bac5fd3915041b1a.json"}}, {"family": "Garcia-Vidal", "given": "Carolina", "initials": "C", "orcid": "0000-0002-8915-0683", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d07f1141779e4aef88a4b126526d241e.json"}}, {"family": "Guidetti", "given": "Anna", "initials": "A"}, {"family": "Khanna", "given": "Nina", "initials": "N"}, {"family": "Kulesekararaj", "given": "Austin", "initials": "A", "orcid": "0000-0003-3180-3570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd4719161efc4d939fe6f4832430a1bc.json"}}, {"family": "Maertens", "given": "Johan", "initials": "J", "orcid": "0000-0003-4257-5980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4701b45871ba4030a2c57c01edcbf6e0.json"}}, {"family": "Hoenigl", "given": "Martin", "initials": "M", "orcid": "0000-0002-1653-2824", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f06a81d02454972bb9b64fea7c14dd4.json"}}, {"family": "Klimko", "given": "Nikolai", "initials": "N", "orcid": "0000-0001-6095-7531", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/da32e1ffe46c49f5a891df4e452b5ce7.json"}}, {"family": "Koehler", "given": "Philipp", "initials": "P"}, {"family": "Pagliuca", "given": "Antonio", "initials": "A"}, {"family": "Passamonti", "given": "Francesco", "initials": "F"}, {"family": "Cornely", "given": "Oliver", "initials": "O", "orcid": "0000-0001-9599-3137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3c62d8346924e69b6c99e4007c3831c.json"}}, {"family": "Pagano", "given": "Livio", "initials": "L", "orcid": "0000-0001-8287-928X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbf92a9779614910aeafcc6c21d880e2.json"}}], "type": "journal article", "published": "2021-11-08", "journal": {"title": "Blood Adv", "issn": "2473-9537", "issn-l": null}, "abstract": "Patients receiving chimeric antigen receptor T cells (CAR-T cells) therapy may be particularly susceptible to coronavirus disease 2019 (COVID-19) because of several factors including the immunosuppression associated to the underlying disease and delayed cytopenias. Regrettably, data on outcomes of CAR-T recipients with COVID-19 are extremely scarce. The aim of this study was to investigate the characteristics and outcomes of COVID-19 in patients treated with CAR-T therapy. The European Hematology Association - Scientific Working Group Infection in Hematology endorsed a survey to collect and analyze data from patients developing COVID-19 after CAR-T therapy. Overall, 459 patients treated with CAR-T cells were reported from 18 European centers. The prevalence of COVID-19 cases was 4.8%. Median time from CAR-T therapy and COVID-19 diagnosis was 169 days. Severe infection occurred in 66.7% of patients and 43.3% of the subjects required admission to ICU. The COVID-19 mortality was 33%. In multivariable analysis, the disease status at the time of COVID-19 trended marginally towards adverse outcome (P=0.075). In conclusion, we documented a high fatality rate for CAR-T patients with COVID-19, supporting the need to design successful interventions to mitigate the risk of infection in this vulnerable group of patients.", "doi": "10.1182/bloodadvances.2021005616", "pmid": "34749396", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "477883"}, {"db": "pmc", "key": "PMC8575532"}], "notes": [], "created": "2021-11-26T15:25:48.657Z", "modified": "2021-11-26T15:25:48.910Z"}, {"entity": "publication", "iuid": "c43d6c2225434e9f9fa38e7116ea1531", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c43d6c2225434e9f9fa38e7116ea1531.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c43d6c2225434e9f9fa38e7116ea1531"}}, "title": "Avian influenza, a new threat to public health in Europe?", "authors": [{"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Baldinelli", "given": "Francesca", "initials": "F"}, {"family": "Fusaro", "given": "Alice", "initials": "A"}, {"family": "Terregino", "given": "Calogero", "initials": "C"}], "type": "journal article", "published": "2021-11-08", "journal": {"title": "Clin Microbiol Infect", "issn": "1469-0691", "issn-l": null}, "abstract": "In our comment we outline the unprecedented situation on avian influenza virus in Europe and globally. We discuss the rapid emergence, diversification, global spread and impact of circulating avian influenza viruses of clade 2.3.4.4b in the light of increasing number of human cases globally and transmission events to other mammal species in Europe. Low levels of circulation of seasonal influenza due to the ongoing SARS-CoV-2 pandemic might hamper the early identification of human avian influenza cases due to lack of awareness or testing. This comment aims to raise awareness among clinicians, microbiologists and animal, public as well as occupational health experts about the ongoing threat of avian influenza viruses to human health also in Europe.", "doi": "10.1016/j.cmi.2021.11.005", "pmid": "34763057", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(21)00632-7"}], "notes": [], "created": "2021-11-26T15:15:47.163Z", "modified": "2021-11-26T15:15:57.578Z"}, {"entity": "publication", "iuid": "83ac762900b94d5e82d42f3f5d2a59e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/83ac762900b94d5e82d42f3f5d2a59e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/83ac762900b94d5e82d42f3f5d2a59e7"}}, "title": "Risk of hospitalization and risk of death for health care workers with COVID-19 in nine European countries, January 2020-January 2021.", "authors": [{"family": "Ferland", "given": "Lisa", "initials": "L"}, {"family": "Carvalho", "given": "Carlos", "initials": "C"}, {"family": "Dias", "given": "Joana Gomes", "initials": "JG"}, {"family": "Lamb", "given": "Favelle", "initials": "F"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Suetens", "given": "Carl", "initials": "C"}, {"family": "Beaut\u00e9", "given": "Julien", "initials": "J"}, {"family": "Kinross", "given": "Pete", "initials": "P"}, {"family": "Plachouras", "given": "Diamantis", "initials": "D"}, {"family": "Hannila-Handelberg", "given": "Tuula", "initials": "T"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "van Gageldonk-Lafeber", "given": "Rianne", "initials": "R"}, {"family": "Teirlinck", "given": "Anne C", "initials": "AC"}, {"family": "Mossong", "given": "Jo\u00ebl", "initials": "J"}, {"family": "Vergison", "given": "Anne", "initials": "A"}, {"family": "Melillo", "given": "Jackie", "initials": "J"}, {"family": "Melillo", "given": "Tanya", "initials": "T"}, {"family": "Mook", "given": "Piers", "initials": "P"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "Coutinho Rehse", "given": "Ana Paula", "initials": "AP"}, {"family": "Monnet", "given": "Dominique L", "initials": "DL"}], "type": "journal article", "published": "2021-11-06", "journal": {"title": "J Hosp Infect", "issn": "1532-2939", "issn-l": null}, "abstract": "We present and compare COVID-19 attack rates for infection, hospitalization, admission to intensive care unit (ICU), and death, in health care workers (HCW) and non-HCWs in nine European countries from 31 January 2020 to 13 January 2021. Adjusted attack rate ratios in HCWs (compared to non-HCWs) were 3.0 [95% confidence interval: 2.2-4.0] for infection, 1.8 [1.2-2.7] for hospitalization, 1.9 [1.1-3.2] for ICU admission and 0.9 [0.4-2.0] for death. Among hospitalized cases, case-fatality ratio was 1.8% in HCWs and 8.2% in non-HCWs. Differences might be due to better/earlier access to treatment, differential under-ascertainment, and to the healthy worker effect.", "doi": "10.1016/j.jhin.2021.10.015", "pmid": "34752802", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0195-6701(21)00379-0"}], "notes": [], "created": "2021-11-26T15:24:11.932Z", "modified": "2021-11-26T15:24:11.966Z"}, {"entity": "publication", "iuid": "1be19e040a094cac92dc986abf48c657", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1be19e040a094cac92dc986abf48c657.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1be19e040a094cac92dc986abf48c657"}}, "title": "Partner responsiveness moderates the relation between COVID-19-related stressors and changes in mood during the pandemic.", "authors": [{"family": "Soares", "given": "Lorrayne Stephane", "initials": "LS"}, {"family": "Rodrigues", "given": "Aliny Cristina", "initials": "AC"}, {"family": "de Paula", "given": "Jonas Jardim", "initials": "JJ"}, {"family": "Thorell", "given": "Lisa B", "initials": "LB"}, {"family": "de Miranda", "given": "Debora Marques", "initials": "DM"}], "type": "case reports", "published": "2021-11-06", "journal": {"title": "Curr Psychol", "issn": "1046-1310", "issn-l": null, "volume": null, "issue": null, "pages": "1-8"}, "abstract": "The COVID-19 pandemic has created an unusually stressful situation for many people around the world. Due to the restrictions, many have been isolated in their homes, and having a responsive partner may have become even more important. The present study aimed to investigate (1) whether there were any differences in social and work-related stressors and changes in negative mood during the COVID-19 pandemic as a function of marital status, and (2) whether perceived partner responsiveness can attenuate the associations between COVID-19-related stressors and changes in negative mood. The participants were 2,400 Brazilian adults recruited via the Internet, using a virtual sampling strategy. They were assigned to three distinct groups based on their relationship status. The results showed that a relatively large proportion of the sample reported increased levels of negative mood, and that married/cohabitating couples reported low levels of negative change in mood compared to single participants. We also found that partner responsiveness attenuated the association between stress and mental health, but only for people who were dating. Our study contributes new insights by showing that effects on mental health during the COVID-19 pandemic are dependent on relationship type and perceived partner responsiveness.", "doi": "10.1007/s12144-021-02429-5", "pmid": "34776716", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2429"}, {"db": "pmc", "key": "PMC8571670"}], "notes": [], "created": "2021-11-26T14:28:31.819Z", "modified": "2021-11-26T14:29:20.306Z"}, {"entity": "publication", "iuid": "280c373efc0a471f938e926d69a253f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/280c373efc0a471f938e926d69a253f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/280c373efc0a471f938e926d69a253f8"}}, "title": "Heart failure in type 2 diabetes: current perspectives on screening, diagnosis and management.", "authors": [{"family": "Ceriello", "given": "Antonio", "initials": "A", "orcid": "0000-0001-8122-3203", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1409105396004023a189c4ea96e0f410.json"}}, {"family": "Catrinoiu", "given": "Doina", "initials": "D"}, {"family": "Chandramouli", "given": "Chanchal", "initials": "C"}, {"family": "Cosentino", "given": "Francesco", "initials": "F"}, {"family": "Dombrowsky", "given": "Annique Cornelia", "initials": "AC"}, {"family": "Itzhak", "given": "Baruch", "initials": "B"}, {"family": "Lalic", "given": "Nebojsa Mali\u0107", "initials": "NM"}, {"family": "Prattichizzo", "given": "Francesco", "initials": "F"}, {"family": "Schnell", "given": "Oliver", "initials": "O"}, {"family": "Seferovi\u0107", "given": "Petar M", "initials": "PM"}, {"family": "Valensi", "given": "Paul", "initials": "P"}, {"family": "Standl", "given": "Eberhard", "initials": "E"}, {"family": "D&CVD EASD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-06", "journal": {"title": "Cardiovasc Diabetol", "issn": "1475-2840", "volume": "20", "issue": "1", "pages": "218", "issn-l": null}, "abstract": "Type 2 diabetes is one of the most relevant risk factors for heart failure, the prevalence of which is increasing worldwide. The aim of the review is to highlight the current perspectives of the pathophysiology of heart failure as it pertains to type 2 diabetes. This review summarizes the proposed mechanistic bases, explaining the myocardial damage induced by diabetes-related stressors and other risk factors, i.e., cardiomyopathy in type 2 diabetes. We highlight the complex pathology of individuals with type 2 diabetes, including the relationship with chronic kidney disease, metabolic alterations, and heart failure. We also discuss the current criteria used for heart failure diagnosis and the gold standard screening tools for individuals with type 2 diabetes. Currently approved pharmacological therapies with primary use in type 2 diabetes and heart failure, and the treatment-guiding role of NT-proBNP are also presented. Finally, the influence of the presence of type 2 diabetes as well as heart failure on COVID-19 severity is briefly discussed.", "doi": "10.1186/s12933-021-01408-1", "pmid": "34740359", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12933-021-01408-1"}], "notes": [], "created": "2021-11-08T09:21:26.835Z", "modified": "2021-11-08T09:21:26.892Z"}, {"entity": "publication", "iuid": "a7133775d8e644d393d407b3da392cab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7133775d8e644d393d407b3da392cab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7133775d8e644d393d407b3da392cab"}}, "title": "Objective Assessment of Covid-19 Severity Affecting the Vocal and Respiratory System Using a Wearable, Autonomous Sound Collar.", "authors": [{"family": "Ishac", "given": "D", "initials": "D"}, {"family": "Matta", "given": "S", "initials": "S"}, {"family": "Bin", "given": "S", "initials": "S"}, {"family": "Aziz", "given": "H", "initials": "H"}, {"family": "Karam", "given": "E", "initials": "E"}, {"family": "Abche", "given": "A", "initials": "A"}, {"family": "Nassar", "given": "G", "initials": "G", "orcid": "0000-0002-8413-3307", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37be6a1d90b243f5ab4ca936d4537a2d.json"}}], "type": "journal article", "published": "2021-11-05", "journal": {"title": "Cell Mol Bioeng", "issn": "1865-5025", "pages": "1-20", "issn-l": null}, "abstract": "Since the outbreak began in January 2020, Covid-19 has affected more than 161 million people worldwide and resulted in about 3.3 million deaths. Despite efforts to detect human infection with the virus as early as possible, the confirmatory test still requires the analysis of sputum or blood with estimated results available within approximately 30 minutes; this may potentially be followed by clinical referral if the patient shows signs of aggravated pneumonia. This work aims to implement a soft collar as a sound device dedicated to the objective evaluation of the pathophysiological state resulting from dysphonia of laryngeal origin or respiratory failure of inflammatory origin, in particular caused by Covid-19.\n\nIn this study, we exploit the vibrations of waves generated by the vocal and respiratory system of 30 people. A biocompatible acoustic sensor embedded in a soft collar around the neck collects these waves. The collar is also equipped with thermal sensors and a cross-data analysis module in both the temporal and frequency domains (STFT). The optimal coupling conditions and the electrical and dimensional characteristics of the sensors were defined based on a mathematical approach using a matrix formalism.\n\nThe characteristics of the signals in the time domain combined with the quantities obtained from the STFT offer multidimensional information and a decision support tool for determining a pathophysiological state representative of the symptoms explored. The device, tested on 30 people, was able to differentiate patients with mild symptoms from those who had developed acute signs of respiratory failure on a severity scale of 1 to 10.\n\nWith the health constraints imposed by the effects of Covid-19, the heavy organization to be implemented resulting from the flow of diagnostics, tests and clinical management, it was urgent to develop innovative and safe biomedical technologies. This passive listening technique will contribute to the non-invasive assessment and dynamic observation of lesions. Moreover, it merits further examination to provide support for medical operators to improve clinical management.\n\nThe online version contains supplementary material available at 10.1007/s12195-021-00712-w.", "doi": "10.1007/s12195-021-00712-w", "pmid": "34777597", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "712"}, {"db": "pmc", "key": "PMC8570400"}], "notes": [], "created": "2021-11-26T14:27:31.945Z", "modified": "2021-11-26T14:27:32.026Z"}, {"entity": "publication", "iuid": "2e52c172c947474e89a0f1ab9da80a78", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e52c172c947474e89a0f1ab9da80a78.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e52c172c947474e89a0f1ab9da80a78"}}, "title": "Internet addiction and sleep quality among medical students during the COVID-19 pandemic: A multinational cross-sectional survey.", "authors": [{"family": "Tahir", "given": "Muhammad Junaid", "initials": "MJ"}, {"family": "Malik", "given": "Najma Iqbal", "initials": "NI", "orcid": "0000-0002-3521-1014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c17242b513143b18e3bb8108f009ca4.json"}}, {"family": "Ullah", "given": "Irfan", "initials": "I", "orcid": "0000-0003-1100-101X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8d5a7e15ae6487cbdda0de3b2a531c3.json"}}, {"family": "Khan", "given": "Hamza Rafique", "initials": "HR"}, {"family": "Perveen", "given": "Shahida", "initials": "S"}, {"family": "Ramalho", "given": "Rodrigo", "initials": "R"}, {"family": "Siddiqi", "given": "Ahsun Rizwan", "initials": "AR", "orcid": "0000-0003-4699-6221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a86efce9fcb4b8d8e3563d416b5fe83.json"}}, {"family": "Waheed", "given": "Summaiya", "initials": "S", "orcid": "0000-0003-1199-3039", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c767edcc9e1940ccb289fa8063ba7c98.json"}}, {"family": "Shalaby", "given": "Mahmoud Mohamed Mohamed", "initials": "MMM", "orcid": "0000-0001-7237-4616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51ae61a95e0243438b5603032c6bc49b.json"}}, {"family": "De Berardis", "given": "Domenico", "initials": "D"}, {"family": "Jain", "given": "Samiksha", "initials": "S"}, {"family": "Vetrivendan", "given": "Gautham Lakshmipriya", "initials": "GL"}, {"family": "Chatterjee", "given": "Harshita", "initials": "H"}, {"family": "Gopar Franco", "given": "William Xochitun", "initials": "WX"}, {"family": "Shafiq", "given": "Muhammad Ahsan", "initials": "MA", "orcid": "0000-0002-2255-4544", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb7c68b72c2a424c8dacee6414d5fb07.json"}}, {"family": "Fatima", "given": "Naira Taiba", "initials": "NT"}, {"family": "Abeysekera", "given": "Maria", "initials": "M", "orcid": "0000-0002-3222-5402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47aee02b846743a4aa205920b66b045a.json"}}, {"family": "Sayyeda", "given": "Qudsia", "initials": "Q"}, {"family": "Shamat", "given": "Shamat Fathi", "initials": "SF"}, {"family": "Aiman", "given": "Wajeeha", "initials": "W", "orcid": "0000-0001-8306-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef22926250924ef3af43732b663197e6.json"}}, {"family": "Akhtar", "given": "Qirat", "initials": "Q"}, {"family": "Devi", "given": "Arooj", "initials": "A"}, {"family": "Aftab", "given": "Anam", "initials": "A"}, {"family": "Shoib", "given": "Sheikh", "initials": "S"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-11-05", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "11", "pages": "e0259594", "issn-l": "1932-6203"}, "abstract": "The emergence of the COVID-19 pandemic has affected the lives of many people, including medical students. The present study explored internet addiction and changes in sleep patterns among medical students during the pandemic and assessed the relationship between them.\n\nA cross-sectional study was carried out in seven countries, the Dominican Republic, Egypt, Guyana, India, Mexico, Pakistan, and Sudan, using a convenience sampling technique, an online survey comprising demographic details, information regarding COVID-19, the Pittsburgh Sleep Quality Index (PSQI), and the Internet Addiction Test (IAT).\n\nIn total, 2749 participants completed the questionnaire. Of the total, 67.6% scored above 30 in the IAT, suggesting the presence of an Internet addiction, and 73.5% scored equal and above 5 in the PSQI, suggesting poor sleep quality. Internet addiction was found to be significant predictors of poor sleep quality, causing 13.2% of the variance in poor sleep quality. Participants who reported COVID-19 related symptoms had disturbed sleep and higher internet addiction levels when compared with those who did not. Participants who reported a diagnosis of COVID-19 reported poor sleep quality. Those living with a COVID-19 diagnosed patient reported higher internet addiction and worse sleep quality compared with those who did not have any COVID-19 patients in their surroundings.\n\nThe results of this study suggest that internet addiction and poor sleep quality are two issues that require addressing amongst medical students. Medical training institutions should do their best to minimize their negative impact, particularly during the current COVID-19 pandemic.", "doi": "10.1371/journal.pone.0259594", "pmid": "34739502", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-19421"}, {"db": "pmc", "key": "PMC8570473"}], "notes": [], "created": "2021-11-08T09:20:03.775Z", "modified": "2021-11-26T15:37:15.553Z"}, {"entity": "publication", "iuid": "8f20f3230f124a80863085063aa508b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f20f3230f124a80863085063aa508b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f20f3230f124a80863085063aa508b4"}}, "title": "Gastrointestinal Manifestations and Possible Mechanisms of COVID-19 in Different Periods.", "authors": [{"family": "Zhang", "given": "Mengmeng", "initials": "M"}, {"family": "Chen", "given": "Luni", "initials": "L"}, {"family": "Qian", "given": "Jiaming", "initials": "J", "orcid": "0000-0001-6611-9475", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/97782f236bdb4f5db68af8f464f1634c.json"}}], "type": "journal article", "published": "2021-11-05", "journal": {"title": "J Dig Dis", "issn": "1751-2980", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19), as a new infectious disease, has spread worldwide. COVID-19 mainly impacts respiratory system, but digestive manifestations have been frequently described in COVID-19 cases as well, even as the initial symptoms. And there have been several reports about the different gastrointestinal (GI) manifestations in mild and severe patients or in remission stages. So it is reasonable to consult that GI symptoms have distinct characteristics in different periods of COVID-19. Therefore, this review article will try to summarize the gastrointestinal manifestations and possible mechanisms of COVID-19 in different periods, and explain the significance of gastrointestinal manifestations in systemic inflammatory injury. This article is protected by copyright. All rights reserved.", "doi": "10.1111/1751-2980.13065", "pmid": "34738727", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-11-08T09:19:20.920Z", "modified": "2021-11-26T15:39:49.918Z"}, {"entity": "publication", "iuid": "32ee20e91fb54cbd8899a8b1077d4d67", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/32ee20e91fb54cbd8899a8b1077d4d67.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/32ee20e91fb54cbd8899a8b1077d4d67"}}, "title": "Physical Function, Cognitive Function, and Daily Activities in Patients Hospitalized Due to COVID-19: A Descriptive Cross-Sectional Study in Sweden.", "authors": [{"family": "Larsson", "given": "Alexandra C", "initials": "AC", "orcid": "0000-0001-9100-4071", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8532302825d744c7b29ccefeb16e11e2.json"}}, {"family": "Palstam", "given": "Annie", "initials": "A"}, {"family": "Persson", "given": "Hanna C", "initials": "HC", "orcid": "0000-0001-8633-3292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc8035c749ab4521b549ea820f6b4389.json"}}], "type": "journal article", "published": "2021-11-04", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "21", "issn-l": null}, "abstract": "An estimated 14-20% of people infected with COVID-19 require medical care. The aim of the present study was to evaluate physical function, cognitive function, and daily activities in patients hospitalized due to COVID-19, and to investigate differences depending on age and admission to the intensive care unit (ICU). This prospective descriptive cross-sectional study included a consecutive sample of 211 patients (mean age 65.1 years, 67.3% men) hospitalized due to COVID-19 in Sweden. Data regarding physical function and daily activities were collected in hospital from July 2020 to February 2021. The average length of hospital stay was 33.8 days, and 48.8% of the patients were admitted to the ICU. Physical function (grip- and lower body strength) was reduced in both groups, and significantly more in the older group, \u226565 years old, compared to the younger. Furthermore, the older group also had significantly less ability to perform activities in daily life, and had significantly reduced cognitive function as compared to the younger age group. In patients treated in the ICU, physical impairments as well as the activity level were significantly more pronounced compared to patients not treated in the ICU. Patients hospitalized due to COVID-19 are physically impaired, have mild cognitive impairments, and have difficulties performing daily activities. The findings in this study indicate the need for out-patient follow-up and rehabilitation for patients hospitalized due to COVID-19, especially in older patients and patients treated in the ICU.", "doi": "10.3390/ijerph182111600", "pmid": "34770113", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182111600"}, {"db": "pmc", "key": "PMC8582899"}], "notes": [], "created": "2021-11-26T15:08:28.992Z", "modified": "2021-11-26T15:08:29.085Z"}, {"entity": "publication", "iuid": "c527b9a6aa9c4e09857d147f3a39a164", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c527b9a6aa9c4e09857d147f3a39a164.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c527b9a6aa9c4e09857d147f3a39a164"}}, "title": "Digital Entry-Level Education in Physiotherapy: a Commentary to Inform Post-COVID-19 Future Directions.", "authors": [{"family": "Rossettini", "given": "Giacomo", "initials": "G", "orcid": "0000-0002-1623-7681", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a762502a2851423abc3f64ebc500eb2f.json"}}, {"family": "Turolla", "given": "Andrea", "initials": "A", "orcid": "0000-0002-1609-8060", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02bc8df4293942a6bb90e78787e347e7.json"}}, {"family": "Gudjonsdottir", "given": "Bjorg", "initials": "B", "orcid": "0000-0003-4566-9333", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/082e09793ae7433796603a7352364699.json"}}, {"family": "Kapreli", "given": "Eleni", "initials": "E", "orcid": "0000-0001-6752-427X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44e98c8f41f042b2834bc757fbefa1ee.json"}}, {"family": "Salchinger", "given": "Beate", "initials": "B", "orcid": "0000-0003-2132-5384", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bad611449f04d4382fec7dfc8f1785e.json"}}, {"family": "Verheyden", "given": "Geert", "initials": "G", "orcid": "0000-0003-3095-8175", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19a2c35a537e4483923467fa8ecef9ab.json"}}, {"family": "Palese", "given": "Alvisa", "initials": "A", "orcid": "0000-0002-3508-844X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea400153bf344f98a5e06367b0442e17.json"}}, {"family": "Dell'Isola", "given": "Andrea", "initials": "A", "orcid": "0000-0002-0319-458X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d8ea417b7c447f8bc4da9f47f9feb39.json"}}, {"family": "de Caro", "given": "John Xerri", "initials": "JX", "orcid": "0000-0003-1198-1660", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aaa4c4a9eeb24a01af410608a82465da.json"}}], "type": "editorial", "published": "2021-11-04", "journal": {"title": "Med Sci Educ", "issn": "2156-8650", "pages": "1-13", "issn-l": null}, "abstract": "Currently, the coronavirus disease 2019 (COVID-19) severely influences physiotherapy education which is based mostly on face-to-face teaching. Thus, educators have been compelled to adapt their pedagogical approaches moving to digital education. In this commentary, we debate on digital education highlighting its effectiveness, the users' perspectives, and its weakness in the context of physiotherapy teaching aimed at informing post-COVID-19 future directions in this educational field. Existing evidence on digital education produced before COVID-19 supports its implementation into entry-level physiotherapy education. However, some challenges (e.g. social inequality and evaluation of students) threaten its applicability in post-COVID-19 era, calling educators to take appropriate actions.", "doi": "10.1007/s40670-021-01439-z", "pmid": "34754600", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "1439"}, {"db": "pmc", "key": "PMC8567978"}], "notes": [], "created": "2021-11-26T15:23:41.362Z", "modified": "2021-11-26T15:23:50.633Z"}, {"entity": "publication", "iuid": "862d1ff1e9f6423da651586d40730006", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/862d1ff1e9f6423da651586d40730006.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/862d1ff1e9f6423da651586d40730006"}}, "title": "Whole-Blood DNA Methylation Analysis Reveals Respiratory Environmental Traits Involved in COVID-19 Severity Following SARS-CoV-2 Infection", "authors": [{"family": "Barturen", "given": "Guillermo", "initials": "G", "orcid": "0000-0003-2103-1028", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a338918e305480497c4e51b5874dd52.json"}}, {"family": "Carnero-Montoro", "given": "Elena", "initials": "E"}, {"family": "Mart\u00ednez-Bueno", "given": "Manuel", "initials": "M"}, {"family": "Rojo-Rello", "given": "Silvia", "initials": "S"}, {"family": "Sobrino", "given": "Beatriz", "initials": "B"}, {"family": "Alc\u00e1ntara-Dom\u00ednguez", "given": "Clara", "initials": "C"}, {"family": "Bernardo", "given": "David", "initials": "D"}, {"family": "Alarc\u00f3n-Riquelme", "given": "Marta E", "initials": "ME"}], "type": "posted-content", "published": "2021-11-03", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.11.03.21260184", "pmid": null, "labels": {"Category: Health": null, "Type: Preprint": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-11-08T09:24:08.423Z", "modified": "2021-11-08T09:24:08.467Z"}, {"entity": "publication", "iuid": "0adda81270ec4cc89f61c155e06af98d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0adda81270ec4cc89f61c155e06af98d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0adda81270ec4cc89f61c155e06af98d"}}, "title": "Telephone-based behavioral activation with mental imagery for depression: A pilot randomized clinical trial in isolated older adults during the Covid-19 pandemic.", "authors": [{"family": "Pellas", "given": "Johnny", "initials": "J", "orcid": "0000-0002-0707-0832", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b194cea3f31a427b99b5dadcc7ab378d.json"}}, {"family": "Renner", "given": "Fritz", "initials": "F"}, {"family": "Ji", "given": "Julie L", "initials": "JL"}, {"family": "Damberg", "given": "Mattias", "initials": "M"}], "type": "journal article", "published": "2021-11-03", "journal": {"title": "Int J Geriatr Psychiatry", "issn": "1099-1166", "issn-l": null}, "abstract": "To shield vulnerable persons, particularly the elderly, during the Covid-19 pandemic governments around the world have advised to use social distancing and self-isolation. Social isolation might put older adults at an increased risk for mental health problems such as depression. There is a need for brief, easy-accessible psychological treatments for depressive symptoms that can be delivered remotely. The aim of this study was to investigate the feasibility, acceptability, and preliminary efficacy of telephone-delivered Behavioral Activation with Mental Imagery (BA-MI) for the treatment of depressive symptoms in individuals 65 years and older living in isolation during the Covid-19 pandemic.\n\nIn this open-label pilot randomized clinical trial, N = 41 individuals aged 65 years or older with clinically significant symptoms of depression were randomly assigned to either a BA-MI treatment condition, or an Attention-Assessment control condition delivered over the telephone over a 4-week period.\n\nDepressive symptoms decreased more in the treatment condition compared to the control condition. At post-treatment, 2 out of 16 participants in the treatment condition met diagnostic criteria for depression compared to 9 out of 13 in the control condition. Most participants in the treatment condition were satisfied with the treatment and few adverse effects were observed.\n\nThis pilot study suggests that behavioral activation with mental imagery delivered over the telephone is feasible, acceptable, and potentially efficacious for the treatment of depressive symptoms in older individuals living in isolation. Replication in larger samples is needed.", "doi": "10.1002/gps.5646", "pmid": "34729823", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T15:41:40.865Z", "modified": "2021-11-26T15:41:40.938Z"}, {"entity": "publication", "iuid": "41c5838635aa470197d9531080584fbb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41c5838635aa470197d9531080584fbb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41c5838635aa470197d9531080584fbb"}}, "title": "Changes in Self-Reported Web-Based Gambling Activity During the COVID-19 Pandemic: Cross-sectional Study.", "authors": [{"family": "Claesdotter-Knutsson", "given": "Emma", "initials": "E", "orcid": "0000-0002-6832-2482", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8738736985b40b3bdf49061f734f62f.json"}}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A", "orcid": "0000-0002-5800-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec14ecdcc0654d8ea864f64ce195752b.json"}}], "type": "journal article", "published": "2021-11-03", "journal": {"title": "JMIR Serious Games", "issn": "2291-9279", "volume": "9", "issue": "4", "pages": "e30747", "issn-l": null}, "abstract": "The COVID\u201119 pandemic has affected not only somatic health with over 3.7 million deaths worldwide, but also has had a huge impact on psychological health, creating what amounts to a mental health crisis. The negative effect of the pandemic on traditional addictions is well described and concerning, and the same has been seen for gambling.\n\nThis study explores self-reported web-based gambling behavior during the COVID\u201119 pandemic in Sweden. We investigated overall changes, but also changes in specific web-based gambling types, and whether they are associated with certain risk factors or lifestyle changes.\n\nOur study is based on an anonymous web-based survey of web panel participants in Sweden (N=1501) designed to study a range of behavioral changes during the COVID\u201119 pandemic. Increases in gambling were analyzed using logistic regression models against sociodemographic data and psychological distress.\n\nThe majority of the respondents who gambled reported no changes in their gambling habits during the COVID\u201119 pandemic. We found significant associations with the problem gambling severity index (PGSI), the Kessler score (indicating psychological distress), employment status, changes in alcohol habits, and self-exclusion when looking at overall changes in gambling activity in the pandemic. In the subgroup that reported an increase in gambling activity, we found an association with both the PGSI and Kessler scores. The PGSI score was also an independent predictor for all specific web-based gambling (horses, sports, poker, and casino) whereas the Kessler score only had a significant impact on changes in casino gambling. In addition, male gender was an independent predictor for gambling on sports and casino gambling.\n\nThe majority of respondents who gambled reported no changes in their gambling activity during the COVID\u201119 pandemic. The group that reported an increase in overall gambling activity during the COVID-19 pandemic represent a group with gambling problems and psychological distress. The group that reported increased sports and casino gambling were often male, and this group seemed to experience more psychological distress.", "doi": "10.2196/30747", "pmid": "34730540", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "v9i4e30747"}, {"db": "pmc", "key": "PMC8568044"}], "notes": [], "created": "2021-11-08T09:15:10.855Z", "modified": "2021-11-26T15:41:19.258Z"}, {"entity": "publication", "iuid": "5bcd844252e14ddfae807c3083021b97", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5bcd844252e14ddfae807c3083021b97.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5bcd844252e14ddfae807c3083021b97"}}, "title": "Changes in Mental Health and Views on Communication and Activities of Public Institutions among Swedes during the COVID-19 Pandemic-A Cross-Sectional Repeated Measures Design.", "authors": [{"family": "Kerstis", "given": "Birgitta", "initials": "B", "orcid": "0000-0003-0242-0343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b50ad01a7fdd43b589b7ec07cf98f220.json"}}, {"family": "Giannotta", "given": "Fabrizia", "initials": "F"}, {"family": "W\u00e5gert", "given": "Petra von Heideken", "initials": "PVH", "orcid": "0000-0001-6292-7010", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4d6dfb26a37419385eb8e257f89d950.json"}}, {"family": "Hellstr\u00f6m", "given": "Charlotta", "initials": "C", "orcid": "0000-0003-1675-4408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a211ac4b50f24a3ca7be0deb42bc3362.json"}}, {"family": "Lindberg", "given": "Daniel", "initials": "D", "orcid": "0000-0002-8541-1727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f40c1556e4545a3a69893d276425af9.json"}}, {"family": "Stier", "given": "Jonas", "initials": "J"}, {"family": "Elv\u00e9n", "given": "Maria", "initials": "M", "orcid": "0000-0001-5356-916X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d90589956db4920b99e166ed4c6dfb2.json"}}], "type": "journal article", "published": "2021-11-03", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "volume": "9", "issue": "11", "issn-l": null}, "abstract": "Although many studies have been conducted on the effects of COVID-19 on individual lives, only a few focus on the changes in mental health and views of public institutions during the pandemic. This study aimed to investigate how mental health, i.e., life satisfaction, worries, and psychological distress, and views on public institutions' communication and activities have changed among Swedes during the COVID-19 pandemic, and whether this was moderated by age and sex. In April-May 2020 (survey 1) and in January-February 2021 (survey 2), 2554 adults and 1904 newly recruited adults, respectively, anonymously completed online surveys. We found that life satisfaction and psychological distress did not change from survey 1 to survey 2. However, the level of worries increased, and the positive views of the public institutions decreased. Moreover, worries and psychological distress increased more in young adults than older adults. Finally, the change in the views of the public institutions was not related to the change in worries. Our results highlight the COVID-19 long-term impacts on individual mental health and call for the need for future research concerning the consequences for the population, especially among young adults. The results also indicate that the views on activities of public authorities decreased over time, especially among men. Given that loss of this trust can have vastly negative effects, for instance, on the vaccine campaign, it is important to monitor this trend, to increase awareness among Swedish authorities. The results also stress for institutions to provide adequate support both during the COVID-19 pandemic and in a future crisis.", "doi": "10.3390/healthcare9111498", "pmid": "34828544", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "healthcare9111498"}, {"db": "pmc", "key": "PMC8625226"}], "notes": [], "created": "2021-12-18T18:17:09.585Z", "modified": "2021-12-18T18:17:15.382Z"}, {"entity": "publication", "iuid": "d6f9488ca04245678ffcb70d7f6bd3e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d6f9488ca04245678ffcb70d7f6bd3e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d6f9488ca04245678ffcb70d7f6bd3e7"}}, "title": "Rolling Circle Amplification in Integrated Microsystems: An Uncut Gem toward Massively Multiplexed Pathogen Diagnostics and Genotyping.", "authors": [{"family": "Soares", "given": "Ruben R G", "initials": "RRG", "orcid": "0000-0001-5958-5232", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2fc2815bc25c4fb78df63294947ee184.json"}}, {"family": "Madaboosi", "given": "Narayanan", "initials": "N"}, {"family": "Nilsson", "given": "Mats", "initials": "M", "orcid": "0000-0001-9985-0387", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/797aac5da3e9472a98af20d637d89784.json"}}], "type": "journal article", "published": "2021-11-02", "journal": {"title": "Acc Chem Res", "issn": "1520-4898", "issn-l": null, "volume": "54", "issue": "21", "pages": "3979-3990"}, "abstract": "The development of robust methods allowing the precise detection of specific nucleic acid sequences is of major societal relevance, paving the way for significant advances in biotechnology and biomedical engineering. These range from a better understanding of human disease at a molecular level, allowing the discovery and development of novel biopharmaceuticals and vaccines, to the improvement of biotechnological processes providing improved food quality and safety, efficient green fuels, and smart textiles. Among these applications, the significance of pathogen diagnostics as the main focus of this Account has become particularly clear during the recent SARS-CoV-2 pandemic. In this context, while RT-PCR is the gold standard method for unambiguous detection of genetic material from pathogens, other isothermal amplification alternatives circumventing rapid heating-cooling cycles up to \u223c95 \u00b0C are appealing to facilitate the translation of the assay into point-of-care (PoC) analytical platforms. Furthermore, the possibility of routinely multiplexing the detection of tens to hundreds of target sequences with single base pair specificity, currently not met by state-of-the-art methods available in clinical laboratories, would be instrumental along the path to tackle emergent viral variants and antimicrobial resistance genes. Here, we advocate that padlock probes (PLPs), first reported by Nilsson et al. in 1994, coupled with rolling circle amplification (RCA), termed here as PLP-RCA, is an underexploited technology in current arena of isothermal nucleic acid amplification tests (NAATs) providing an unprecedented degree of multiplexing, specificity, versatility, and amenability to integration in miniaturized PoC platforms. Furthermore, the intrinsically digital amplification of PLP-RCA retains spatial information and opens new avenues in the exploration of pathogenesis with spatial multiomics analysis of infected cells and tissue.The Account starts by introducing PLP-RCA in a nutshell focusing individually on the three main assay steps, namely, (1) PLP design and ligation mechanism, (2) RCA after probe ligation, and (3) detection of the RCA products. Each subject is touched upon succinctly but with sufficient detail for the reader to appreciate some assay intricacies and degree of versatility depending on the analytical challenge at hand. After familiarizing the reader with the method, we discuss specific examples of research in our group and others using PLP-RCA for viral, bacterial, and fungal diagnostics in a variety of clinical contexts, including the genotyping of antibiotic resistance genes and viral subtyping. Then, we dissect key developments in the miniaturization and integration of PLP-RCA to minimize user input, maximize analysis throughput, and expedite the time to results, ultimately aiming at PoC applications. These developments include molecular enrichment for maximum sensitivity, spatial arrays to maximize analytical throughput, automation of liquid handling to streamline the analytical workflow in miniaturized devices, and seamless integration of signal transduction to translate RCA product titers (and ideally spatial information) into a readable output. Finally, we position PLP-RCA in the current landscape of NAATs and furnish a systematic Strengths, Weaknesses, Opportunities and Threats analysis to shine light upon unpolished edges to uncover the gem with potential for ubiquitous, precise, and unbiased pathogen diagnostics.", "doi": "10.1021/acs.accounts.1c00438", "pmid": "34637281", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC8567418"}], "notes": [], "created": "2021-10-21T05:29:45.915Z", "modified": "2021-12-07T10:01:21.291Z"}, {"entity": "publication", "iuid": "7c8fb306e45e4631a707195122800f01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7c8fb306e45e4631a707195122800f01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7c8fb306e45e4631a707195122800f01"}}, "title": "Management of personal protective equipment during the COVID-19 pandemic in England and the state of New York: A comparative case study.", "authors": [{"family": "Barber", "given": "Amy", "initials": "A"}, {"family": "Vinzent", "given": "Anna\u00eblle", "initials": "A"}, {"family": "Williams", "given": "Imani", "initials": "I"}], "type": "journal article", "published": "2021-11-02", "journal": {"title": "J Emerg Manag", "issn": "1543-5865", "issn-l": null, "volume": "18", "issue": "7", "pages": "71-89"}, "abstract": "The COVID-19 crisis placed extraordinary demands on the supply of personal protective equipment (PPE) at the beginning of 2020. These were coupled with shocks to the supply chain resulting from the disease. Many typically well-resourced health systems faced subsequent shortages of equipment and had to implement new strategies to manage their stocks. Stockpiles of protective equipment were held in both the United States and United Kingdom intended to prevent shortages.\r\n\r\nCross-comparative case study approach by applying Pettigrew and Whipp's framework for change management.\r\n\r\nThe health systems of England and New York state from January 2020 to the end of April 2020.\r\n\r\nBoth cases reacted slowly to their outbreaks and faced problems with supplying enough PPE to their health systems. Their stockpiles were not enough to prevent shortages, with many distribution problems resulting from inadequate governance mechanisms. No sustainable responses to supply disruptions were implemented during the study period in either case. Health systems planned interventions along each part of the supply chain from production and importing, to usage guidelines.\r\n\r\nGlobal supply chains are vulnerable to disruptions caused by international crises, and existing mitigation strategies have not been wholly successful. The existence of stockpiles is insufficient to preventing shortages of necessary equipment in clinical settings. Both the governance and quality of stockpiles, as well as distribution channels are important for preventing shortages. At the time of writing, it is not possible to judge the strength of strategies adopted in these cases.", "doi": "10.5055/jem.0531", "pmid": "34723349", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "jem.0531"}], "notes": [], "created": "2021-11-02T15:44:29.443Z", "modified": "2021-11-02T15:45:06.409Z"}, {"entity": "publication", "iuid": "a7e380d43e2a49ae9d45952a3a365992", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7e380d43e2a49ae9d45952a3a365992.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7e380d43e2a49ae9d45952a3a365992"}}, "title": "Longitudinal Follow Up of Immune Responses to SARS-CoV-2 in Health Care Workers in Sweden With Several Different Commercial IgG-Assays, Measurement of Neutralizing Antibodies and CD4+ T-Cell Responses.", "authors": [{"family": "Marklund", "given": "Emelie", "initials": "E"}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Lundgren", "given": "Anna", "initials": "A"}, {"family": "Liljeqvist", "given": "Jan-\u00c5ke", "initials": "J\u00c5"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Bemark", "given": "Mats", "initials": "M"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-11-02", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "12", "issue": null, "pages": "750448"}, "abstract": "The risk of SARS-CoV-2 infection among health care workers (HCWs) is a concern, but studies that conclusively determine whether HCWs are over-represented remain limited. Furthermore, methods used to confirm past infection vary and the immunological response after mild COVID-19 is still not well defined.\n\n314 HCWs were recruited from a Swedish Infectious Diseases clinic caring for COVID-19 patients. IgG antibodies were measured using two commercial assays (Abbot Architect nucleocapsid (N)-assay and YHLO iFlash-1800 N and spike (S)-assays) at five time-points, from March 2020 to January 2021, covering two pandemic waves. Seroprevalence was assessed in matched blood donors at three time-points. More extensive analyses were performed in 190 HCWs in September/October 2020, including two additional IgG-assays (DiaSorin LiaisonXL S1/S2 and Abbot Architect receptor-binding domain (RBD)-assays), neutralizing antibodies (NAbs), and CD4+ T-cell reactivity using an in-house developed in vitro whole-blood assay based on flow cytometric detection of activated cells after stimulation with Spike S1-subunit or Spike, Membrane and Nucleocapsid (SMN) overlapping peptide pools.\n\nSeroprevalence was higher among HCWs compared to sex and age-matched blood donors at all time-points. Seropositivity increased from 6.4% to 16.3% among HCWs between May 2020 and January 2021, compared to 3.6% to 11.9% among blood donors. We found significant correlations and high levels of agreement between NAbs and all four commercial IgG-assays. At 200-300 days post PCR-verified infection, there was a wide variation in sensitivity between the commercial IgG-assays, ranging from <30% in the N-assay to >90% in the RBD-assay. There was only moderate agreement between NAbs and CD4+ T-cell reactivity to S1 or SMN. Pre-existing CD4+ T-cell reactivity was present in similar proportions among HCW who subsequently became infected and those that did not.\n\nHCWs in COVID-19 patient care in Sweden have been infected with SARS-CoV-2 at a higher rate compared to blood donors. We demonstrate substantial variation between different IgG-assays and propose that multiple serological targets should be used to verify past infection. Our data suggest that CD4+ T-cell reactivity is not a suitable measure of past infection and does not reliably indicate protection from infection in naive individuals.", "doi": "10.3389/fimmu.2021.750448", "pmid": "34795668", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Research Area: Vaccine": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null, "Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pmc", "key": "PMC8593002"}], "notes": [], "created": "2021-12-13T08:52:58.680Z", "modified": "2022-02-14T15:04:31.373Z"}, {"entity": "publication", "iuid": "d407dcf3c4104c5cac5305cf00d65c47", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d407dcf3c4104c5cac5305cf00d65c47.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d407dcf3c4104c5cac5305cf00d65c47"}}, "title": "Identification and Development of Therapeutics for COVID-19.", "authors": [{"family": "Rando", "given": "Halie M", "initials": "HM", "orcid": "0000-0001-7688-1770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b5a9f4ec1bd48579abca9895dab3ea7.json"}}, {"family": "Wellhausen", "given": "Nils", "initials": "N", "orcid": "0000-0001-8955-7582", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/934767f0228241648d70c7b00527deff.json"}}, {"family": "Ghosh", "given": "Soumita", "initials": "S", "orcid": "0000-0002-2783-2750", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5304077580743148d3d23ee7c77be93.json"}}, {"family": "Lee", "given": "Alexandra J", "initials": "AJ", "orcid": "0000-0002-0208-3730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/761782ce14b542078b3ee6c0db2bb6ce.json"}}, {"family": "Dattoli", "given": "Anna Ada", "initials": "AA", "orcid": "0000-0003-1462-831X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fc8cf6436ef47e99880470f63f5f86a.json"}}, {"family": "Hu", "given": "Fengling", "initials": "F", "orcid": "0000-0003-1081-5038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a309350c038479199dc70af0e80a8e6.json"}}, {"family": "Byrd", "given": "James Brian", "initials": "JB", "orcid": "0000-0002-0509-3520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bc319c5d0d74676875bd9ff266f5e80.json"}}, {"family": "Rafizadeh", "given": "Diane N", "initials": "DN", "orcid": "0000-0002-2838-067X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69c8d2c22f44431ea262b7266d6be0de.json"}}, {"family": "Lordan", "given": "Ronan", "initials": "R", "orcid": "0000-0001-9668-3368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0126a49dfcdf49fcb53041fbdcd91706.json"}}, {"family": "Qi", "given": "Yanjun", "initials": "Y", "orcid": "0000-0002-5796-7453", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d48badb4eff4f4f9bf3f15632f0c3a7.json"}}, {"family": "Sun", "given": "Yuchen", "initials": "Y"}, {"family": "Brueffer", "given": "Christian", "initials": "C", "orcid": "0000-0002-3826-0989", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c4f95c1889f4f098676404aec6125ca.json"}}, {"family": "Field", "given": "Jeffrey M", "initials": "JM", "orcid": "0000-0001-7161-7284", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/851e90805f1a44b2b92711899eedb386.json"}}, {"family": "Ben Guebila", "given": "Marouen", "initials": "M", "orcid": "0000-0001-5934-966X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e04fc9008f7f4307a76515f913f19adf.json"}}, {"family": "Jadavji", "given": "Nafisa M", "initials": "NM", "orcid": "0000-0002-3557-7307", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/202cad28eb7f4f67a152ecc180ad9ffb.json"}}, {"family": "Skelly", "given": "Ashwin N", "initials": "AN", "orcid": "0000-0002-1565-3376", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9818ecec2a65431faf931d73ea71bcb2.json"}}, {"family": "Ramsundar", "given": "Bharath", "initials": "B", "orcid": "0000-0001-8450-4262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/461ff07ac9794d8cb1bc205d94bb193f.json"}}, {"family": "Wang", "given": "Jinhui", "initials": "J", "orcid": "0000-0002-5796-8130", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5243fdc11744ba89697e8fdf9c2feee.json"}}, {"family": "Goel", "given": "Rishi Raj", "initials": "RR", "orcid": "0000-0003-1715-5191", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ad2f4cb84774051bb9422f314ec0f11.json"}}, {"family": "Park", "given": "YoSon", "initials": "Y", "orcid": "0000-0002-0465-4744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d3c095fe591449a8c122645bf540ed5.json"}}, {"family": "COVID-19 Review Consortium  Vikas Bansal,  John P. Barton,  Simina M. Boca,  Joel D. Boerckel,  Christian Brueffer,  James Brian Byrd,  Stephen Capone,  Shikta Das,  Anna Ada Dattoli,  John J. Dziak,  Jeffrey M. Field,  Soumita Ghosh,  Anthony Gitter,  Rishi Raj Goel,  Casey S. Greene,  Marouen Ben Guebila,  Daniel S. Himmelstein,  Fengling Hu,  Nafisa M. Jadavji,  Jeremy P. Kamil,  Sergey Knyazev,  Likhitha Kolla,  Alexandra J. Lee,  Ronan Lordan,  Tiago Lubiana,  Temitayo Lukan,  Adam L. MacLean,  David Mai,  Serghei Mangul,  David Manheim,  Lucy D\u2019Agostino McGowan,  Amruta Naik,  YoSon Park,  Dimitri Perrin,  Yanjun Qi,  Diane N. Rafizadeh,  Bharath Ramsundar,  Halie M. Rando,  Sandipan Ray,  Michael P. Robson,  Vincent Rubinetti,  Elizabeth Sell,  Lamonica Shinholster,  Ashwin N. Skelly,  Yuchen Sun,  Yusha Sun,  Gregory L. Szeto,  Ryan Velazquez,  Jinhui Wang,  Nils Wellhausen", "given": "", "initials": ""}, {"family": "Boca", "given": "Simina M", "initials": "SM", "orcid": "0000-0002-1400-3398", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3eb0ffeffea24d5cb745b5ca86648e60.json"}}, {"family": "Gitter", "given": "Anthony", "initials": "A", "orcid": "0000-0002-5324-9833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7085c8743e3442859ad6f23198c85456.json"}}, {"family": "Greene", "given": "Casey S", "initials": "CS", "orcid": "0000-0001-8713-9213", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42aaaac8b65642538f28f9cd2045ab8d.json"}}], "type": "journal article", "published": "2021-11-02", "journal": {"title": "mSystems", "issn": "2379-5077", "pages": "e0023321", "issn-l": null}, "abstract": "After emerging in China in late 2019, the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread worldwide, and as of mid-2021, it remains a significant threat globally. Only a few coronaviruses are known to infect humans, and only two cause infections similar in severity to SARS-CoV-2: Severe acute respiratory syndrome-related coronavirus, a species closely related to SARS-CoV-2 that emerged in 2002, and Middle East respiratory syndrome-related coronavirus, which emerged in 2012. Unlike the current pandemic, previous epidemics were controlled rapidly through public health measures, but the body of research investigating severe acute respiratory syndrome and Middle East respiratory syndrome has proven valuable for identifying approaches to treating and preventing novel coronavirus disease 2019 (COVID-19). Building on this research, the medical and scientific communities have responded rapidly to the COVID-19 crisis and identified many candidate therapeutics. The approaches used to identify candidates fall into four main categories: adaptation of clinical approaches to diseases with related pathologies, adaptation based on virological properties, adaptation based on host response, and data-driven identification (ID) of candidates based on physical properties or on pharmacological compendia. To date, a small number of therapeutics have already been authorized by regulatory agencies such as the Food and Drug Administration (FDA), while most remain under investigation. The scale of the COVID-19 crisis offers a rare opportunity to collect data on the effects of candidate therapeutics. This information provides insight not only into the management of coronavirus diseases but also into the relative success of different approaches to identifying candidate therapeutics against an emerging disease. IMPORTANCE The COVID-19 pandemic is a rapidly evolving crisis. With the worldwide scientific community shifting focus onto the SARS-CoV-2 virus and COVID-19, a large number of possible pharmaceutical approaches for treatment and prevention have been proposed. What was known about each of these potential interventions evolved rapidly throughout 2020 and 2021. This fast-paced area of research provides important insight into how the ongoing pandemic can be managed and also demonstrates the power of interdisciplinary collaboration to rapidly understand a virus and match its characteristics with existing or novel pharmaceuticals. As illustrated by the continued threat of viral epidemics during the current millennium, a rapid and strategic response to emerging viral threats can save lives. In this review, we explore how different modes of identifying candidate therapeutics have borne out during COVID-19.", "doi": "10.1128/mSystems.00233-21", "pmid": "34726496", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8562484"}], "notes": [], "created": "2021-11-08T09:05:54.814Z", "modified": "2021-11-08T09:05:55.435Z"}, {"entity": "publication", "iuid": "6c2429fdd2724204a56226054af6dd87", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c2429fdd2724204a56226054af6dd87.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c2429fdd2724204a56226054af6dd87"}}, "title": "Youths' and Parents' Experiences and Perceived Effects of Internet-Based Cognitive Behavioral Therapy for Anxiety Disorders in Primary Care: Mixed Methods Study.", "authors": [{"family": "Lilja", "given": "Josefine Lotten", "initials": "JL", "orcid": "0000-0003-3623-5760", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3afa9b5d0b6448a5ba4a74576c5c96ed.json"}}, {"family": "Rupcic Ljustina", "given": "Mirna", "initials": "M", "orcid": "0000-0002-7904-326X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53b6cdc53961456693332fa4df4e77b5.json"}}, {"family": "Nissling", "given": "Linnea", "initials": "L", "orcid": "0000-0001-6479-2973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/efa4203dddeb46abacba7575fd13e6a1.json"}}, {"family": "Larsson", "given": "Anna Caroline", "initials": "AC", "orcid": "0000-0001-7530-3039", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ddc347021dd42018899efe7a3790588.json"}}, {"family": "Weineland", "given": "Sandra", "initials": "S", "orcid": "0000-0003-2428-4004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87597556008d43bf8cdbf52bcc98774b.json"}}], "type": "journal article", "published": "2021-11-01", "journal": {"title": "JMIR Pediatr Parent", "issn": "2561-6722", "volume": "4", "issue": "4", "pages": "e26842", "issn-l": null}, "abstract": "Anxiety is common among youths in primary care. Face-to-face treatment has been the first choice for clinicians, but during the COVID-19 pandemic, digital psychological interventions have substantially increased. Few studies have examined young people's interest in internet treatment or the attitudes they and their parents have toward it.\n\nThis study aims to investigate adolescents' and parents' attitudes toward and experiences of internet-based cognitive behavioral anxiety treatment in primary care and its presumptive effects.\n\nThe study used mixed methods, analyzing qualitative data thematically and quantitative data with nonparametric analysis. Participants were 14 adolescents and 14 parents recruited in adolescent primary health care clinics. The adolescents and their parents filled out mental health questionnaires before and after treatment, and were interviewed during ongoing treatment.\n\nThe quantitative data indicated that the internet-delivered cognitive behavioral therapy program used in this study was successful in reducing symptoms (\u03c722=8.333; P=.02) and that adolescents' motivation is essential to the treatment outcome (r=0.58; P=.03). The qualitative results show that youths highly value their independence and freedom to organize treatment work on their own terms. The parents expressed uncertainty about their role and how to support their child in treatment. It was important for parents to respect the youths' need for autonomy while also engaging with them in the treatment work.\n\nInternet treatment in primary care is accepted by both youths and their parents, who need clarification about the difference between their role and the therapist's role. Patient motivation should be considered before treatment, and therapists need to continue to develop the virtual alliance. Finally, primary care should be clearer in informing adolescents and their parents about the possibility of internet treatment.", "doi": "10.2196/26842", "pmid": "34723830", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "v4i4e26842"}], "notes": [], "created": "2021-11-02T15:45:37.788Z", "modified": "2021-11-02T15:45:53.028Z"}, {"entity": "publication", "iuid": "e441957c608a4603accba1b7e3c65524", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e441957c608a4603accba1b7e3c65524.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e441957c608a4603accba1b7e3c65524"}}, "title": "Transient increased immunoglobulin levels in a hyper-IgM syndrome patient with COVID-19 infection.", "authors": [{"family": "Safarirad", "given": "Molood", "initials": "M"}, {"family": "Ganji", "given": "Ali Abbaszadeh", "initials": "AA"}, {"family": "Nazari", "given": "Farzad", "initials": "F"}, {"family": "Yazdani", "given": "Reza", "initials": "R"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Motlagh", "given": "Ahmad Vosughi", "initials": "AV"}], "type": "case reports", "published": "2021-11-01", "journal": {"title": "Allergol Immunopathol (Madr)", "issn": "1578-1267", "volume": "49", "issue": "6", "pages": "63-66", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people around the world. This zoonotic-enveloped virus is primarily transmitted through inhalation. Infected people are commonly asymptomatic or manifest mild symptoms, including fever, cough, diarrhea, and fatigue. However, it may lead to severe patterns associated with multiple organ failure in individuals with an impaired immune system.\n\nHere we report a 7-year-old girl with hyper-immunoglobulin M (IgM) (HIgM) phenotype, admitted to the hospital emergency department with fever, cough, and pneumonia symptoms because of the COVID-19 infection. Coronavirus infection was confirmed by a positive real-time polymerase chain reaction test. Surprisingly, serum levels of both IgG and IgA of the patient were transiently normalized during the COVID-19 infection when tested prior to the monthly injection of intravenous immunoglobulin. After she recovered from the COVID infection, her immunoglobulin levels returned to the primary stage and she demonstrated HIgM phenotype.\n\nSince this transient increase in the levels of immunoglobulins was solely observed during the COVID-19 infection, and no other infectious episodes were diagnosed in the patient, clarifying the exact cause would help to understand in a better manner the implications and specification of humoral immunity in patients with primary antibody deficiencies.", "doi": "10.15586/aei.v49i6.92", "pmid": "34761659", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T15:17:15.274Z", "modified": "2021-11-26T15:17:15.308Z"}, {"entity": "publication", "iuid": "6a88d04a68fa4a1b84cde55ec30756bc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a88d04a68fa4a1b84cde55ec30756bc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a88d04a68fa4a1b84cde55ec30756bc"}}, "title": "The Role of Perceived Organizational Support in Mental Health of Healthcare Workers During the COVID-19 Pandemic: A Cross-Sectional Study.", "authors": [{"family": "Chatzittofis", "given": "Andreas", "initials": "A"}, {"family": "Constantinidou", "given": "Anastasia", "initials": "A"}, {"family": "Artemiadis", "given": "Artemios", "initials": "A"}, {"family": "Michailidou", "given": "Kyriaki", "initials": "K"}, {"family": "Karanikola", "given": "Maria N K", "initials": "MNK"}], "type": "journal article", "published": "2021-11-01", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "707293", "issn-l": "1664-0640"}, "abstract": "Background: Data support the link between the coronavirus disease 2019 (COVID-19) pandemic and mental distress in healthcare workers (HCWs). Although previous studies have documented the association between organizational policies and employees' psychological and mental status, there is still scant evidence regarding the effect of perceived organizational support (POS) on mental distress in HCWs during the pandemic. Aims: The present study aimed to assess the association between POS and mental distress in HCWs during the COVID-19 pandemic. The role of POS in stress, depressive and trauma symptoms in HCWs was investigated. Methods: This was an online cross-sectional study in 424 HCWs. Data were collected during the first wave of the pandemic, and included demographics, a 7-item questionnaire assessing POS, the \"Patient Health Questionnaire\" assessing depressive symptoms, the \"Impact of Events Scale Revised,\" measuring post-traumatic stress disorder (PTSD) symptoms and the \"Perceived Stress Scale\" assessing perceived stress. Results: The mean POS score was 3.33 [standard deviation:1.85; range 0-7]. Younger (p < 0.001), less experienced (p < 0.001), female (p = 0.002), and non-physician HCWs (p = 0.031) were more likely to report lower self-perceived organizational support than older, male, more experienced physicians. Self-perceived organizational support was significantly and negatively associated with and self-assessed intensity of stress, depressive and traumatic symptoms, after adjusting for putative confounders (p < 0.001). Discussion: Self-perceived organizational support was significantly associated with HCWs' self-assessed mental status during the pandemic. Organizational support and mental distress should be addressed simultaneously in HCWs during the COVID-19 pandemic to increase resilience among them.", "doi": "10.3389/fpsyt.2021.707293", "pmid": "34790134", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8591071"}], "notes": [], "created": "2021-11-26T14:10:56.848Z", "modified": "2021-11-26T14:10:56.860Z"}, {"entity": "publication", "iuid": "d5e8b547d4e5441691d8aed2a6a281ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5e8b547d4e5441691d8aed2a6a281ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5e8b547d4e5441691d8aed2a6a281ae"}}, "title": "COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study.", "authors": [{"family": "Chatzikonstantinou", "given": "Thomas", "initials": "T", "orcid": "0000-0003-4105-1253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/23021761f08c4fefa1086c5c865f5b10.json"}}, {"family": "Kapetanakis", "given": "Anargyros", "initials": "A"}, {"family": "Scarf\u00f2", "given": "Lydia", "initials": "L"}, {"family": "Karakatsoulis", "given": "Georgios", "initials": "G"}, {"family": "Allsup", "given": "David", "initials": "D", "orcid": "0000-0001-6159-6109", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2a3916e351f436e8408a950d209d2e7.json"}}, {"family": "Cabrero", "given": "Alejandro Alonso", "initials": "AA"}, {"family": "Andres", "given": "Martin", "initials": "M", "orcid": "0000-0001-9891-2988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa6138aa170b4ff3a8dd2f86a6470f25.json"}}, {"family": "Antic", "given": "Darko", "initials": "D"}, {"family": "Baile", "given": "M\u00f3nica", "initials": "M"}, {"family": "Baliakas", "given": "Panagiotis", "initials": "P"}, {"family": "Bron", "given": "Dominique", "initials": "D"}, {"family": "Capasso", "given": "Antonella", "initials": "A"}, {"family": "Chatzileontiadou", "given": "Sofia", "initials": "S"}, {"family": "Cordoba", "given": "Raul", "initials": "R"}, {"family": "Correa", "given": "Juan-Gonzalo", "initials": "JG"}, {"family": "Cu\u00e9llar-Garc\u00eda", "given": "Carolina", "initials": "C"}, {"family": "De Paoli", "given": "Lorenzo", "initials": "L"}, {"family": "De Paolis", "given": "Maria Rosaria", "initials": "MR"}, {"family": "Del Poeta", "given": "Giovanni", "initials": "G"}, {"family": "Demosthenous", "given": "Christos", "initials": "C"}, {"family": "Dimou", "given": "Maria", "initials": "M", "orcid": "0000-0001-8197-9895", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7193d5fe6b549c4a2b9786e7572d63f.json"}}, {"family": "Donaldson", "given": "David", "initials": "D"}, {"family": "Doubek", "given": "Michael", "initials": "M", "orcid": "0000-0002-1269-6282", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5407e6865c7045f1bc6e595eb7047eaa.json"}}, {"family": "Efstathopoulou", "given": "Maria", "initials": "M"}, {"family": "Eichhorst", "given": "Barbara", "initials": "B"}, {"family": "El-Ashwah", "given": "Shaimaa", "initials": "S"}, {"family": "Enrico", "given": "Alicia", "initials": "A", "orcid": "0000-0002-1983-6145", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/074670e0454c43a3b9435c0312fc6a35.json"}}, {"family": "Espinet", "given": "Blanca", "initials": "B", "orcid": "0000-0002-4294-8145", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0f362ec00c9449c95b6e68c76c8db2c.json"}}, {"family": "Farina", "given": "Lucia", "initials": "L"}, {"family": "Ferrari", "given": "Angela", "initials": "A"}, {"family": "Foglietta", "given": "Myriam", "initials": "M"}, {"family": "Frederiksen", "given": "Henrik", "initials": "H", "orcid": "0000-0001-8905-0220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dd8e0ff7ffe4154a4bf63e0e2d2ebe5.json"}}, {"family": "F\u00fcrstenau", "given": "Moritz", "initials": "M", "orcid": "0000-0002-6593-0140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e940c65de1ea4811982480c9e043e3ed.json"}}, {"family": "Garc\u00eda-Marco", "given": "Jos\u00e9 A", "initials": "JA", "orcid": "0000-0002-8993-5982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae24000421684dd4b672a42c0175db23.json"}}, {"family": "Garc\u00eda-Serra", "given": "Roc\u00edo", "initials": "R", "orcid": "0000-0003-4857-1016", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64be4a6881bd4ee2bb3cdfe4f98aed63.json"}}, {"family": "Gentile", "given": "Massimo", "initials": "M"}, {"family": "Gimeno", "given": "Eva", "initials": "E"}, {"family": "Glenth\u00f8j", "given": "Andreas", "initials": "A"}, {"family": "Gomes da Silva", "given": "Maria", "initials": "M"}, {"family": "Gutwein", "given": "Odit", "initials": "O"}, {"family": "Hakobyan", "given": "Yervand K", "initials": "YK", "orcid": "0000-0002-9074-7831", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b93ae93cedf140bd818d21a7787a5b18.json"}}, {"family": "Herishanu", "given": "Yair", "initials": "Y"}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jos\u00e9 \u00c1ngel", "initials": "J\u00c1", "orcid": "0000-0003-4550-757X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d071af0c0a14dc695bcda29033b49ce.json"}}, {"family": "Herold", "given": "Tobias", "initials": "T", "orcid": "0000-0002-9615-9432", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce3888ebd0dc407983804c9f7cf2a1d5.json"}}, {"family": "Innocenti", "given": "Idanna", "initials": "I"}, {"family": "Itchaki", "given": "Gilad", "initials": "G"}, {"family": "Jaksic", "given": "Ozren", "initials": "O"}, {"family": "Janssens", "given": "Ann", "initials": "A"}, {"family": "Kalashnikova", "given": "\u041elga B", "initials": "\u041eB", "orcid": "0000-0002-1856-1055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c829e1da08b14c72ad0aa0eafd5b485d.json"}}, {"family": "Kalici\u0144ska", "given": "El\u017cbieta", "initials": "E"}, {"family": "Karlsson", "given": "Linda Katharina", "initials": "LK", "orcid": "0000-0003-3317-7550", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7755dec3898c4e33a5729825a8d2dacd.json"}}, {"family": "Kater", "given": "Arnon P", "initials": "AP"}, {"family": "Kersting", "given": "Sabina", "initials": "S"}, {"family": "Labrador", "given": "Jorge", "initials": "J", "orcid": "0000-0002-3696-0287", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9eab3a75d0294b74a6f9aa9eeb0b32f4.json"}}, {"family": "Lad", "given": "Deepesh", "initials": "D", "orcid": "0000-0003-3754-7774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7beb53ecbdd449e8bee3890151070af0.json"}}, {"family": "Laurenti", "given": "Luca", "initials": "L"}, {"family": "Levin", "given": "Mark-David", "initials": "MD", "orcid": "0000-0003-2139-3547", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf8f1dcff71143b7932a884334bc1eff.json"}}, {"family": "Lista", "given": "Enrico", "initials": "E"}, {"family": "Lopez-Garcia", "given": "Alberto", "initials": "A", "orcid": "0000-0002-5354-5261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c785356a67e4cbb9835fe9ce04a6153.json"}}, {"family": "Malerba", "given": "Lara", "initials": "L"}, {"family": "Marasca", "given": "Roberto", "initials": "R", "orcid": "0000-0002-6431-6878", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d0c310570274da69fb28946c66020e7.json"}}, {"family": "Marchetti", "given": "Monia", "initials": "M", "orcid": "0000-0001-7615-0572", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2fd4079badec41a7a7215d9b8fc37fb4.json"}}, {"family": "Marquet", "given": "Juan", "initials": "J"}, {"family": "Mattsson", "given": "Mattias", "initials": "M"}, {"family": "Mauro", "given": "Francesca R", "initials": "FR"}, {"family": "Milosevic", "given": "Ivana", "initials": "I"}, {"family": "Mir\u00e1s", "given": "Fatima", "initials": "F"}, {"family": "Morawska", "given": "Marta", "initials": "M"}, {"family": "Motta", "given": "Marina", "initials": "M"}, {"family": "Munir", "given": "Talha", "initials": "T"}, {"family": "Murru", "given": "Roberta", "initials": "R"}, {"family": "Niemann", "given": "Carsten U", "initials": "CU", "orcid": "0000-0001-9880-5242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b594ef0644e54a568dbe3de6847c4369.json"}}, {"family": "Rodrigues", "given": "Raquel Nunes", "initials": "RN"}, {"family": "Olivieri", "given": "Jacopo", "initials": "J"}, {"family": "Orsucci", "given": "Lorella", "initials": "L"}, {"family": "Papaioannou", "given": "Maria", "initials": "M"}, {"family": "Pavlovsky", "given": "Miguel Arturo", "initials": "MA"}, {"family": "Piskunova", "given": "Inga", "initials": "I"}, {"family": "Popov", "given": "Viola Maria", "initials": "VM", "orcid": "0000-0002-1200-379X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d0058f0e37c4164adfdc4cff9f162cc.json"}}, {"family": "Quaglia", "given": "Francesca Maria", "initials": "FM", "orcid": "0000-0003-4347-3775", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81838e15a03441b88702c3449ef0c4d1.json"}}, {"family": "Quaresmini", "given": "Giulia", "initials": "G", "orcid": "0000-0002-0993-9693", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fb23db20963401a96c3ac6e030259ae.json"}}, {"family": "Qvist", "given": "Kristian", "initials": "K"}, {"family": "Reda", "given": "Gianluigi", "initials": "G", "orcid": "0000-0003-4687-7089", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ecd84c2c9bf44fd8c7635c1420621a4.json"}}, {"family": "Rigolin", "given": "Gian Matteo", "initials": "GM", "orcid": "0000-0002-8370-5190", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e7020e591b04b72ac7ee221f8b262ba.json"}}, {"family": "Ruchlemer", "given": "Rosa", "initials": "R"}, {"family": "Saghumyan", "given": "Gevorg", "initials": "G"}, {"family": "Shrestha", "given": "Amit", "initials": "A"}, {"family": "\u0160imkovi\u010d", "given": "Martin", "initials": "M"}, {"family": "\u0160pa\u010dek", "given": "Martin", "initials": "M"}, {"family": "Sportoletti", "given": "Paolo", "initials": "P"}, {"family": "Stanca", "given": "Oana", "initials": "O"}, {"family": "Stavroyianni", "given": "Niki", "initials": "N"}, {"family": "Tadmor", "given": "Tamar", "initials": "T", "orcid": "0000-0002-3435-8612", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c968d69d0b545aaa6c99104419ac961.json"}}, {"family": "Te Raa", "given": "Doreen", "initials": "D"}, {"family": "Tonino", "given": "Sanne H", "initials": "SH"}, {"family": "Trentin", "given": "Livio", "initials": "L", "orcid": "0000-0003-1222-6149", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/affdda253d72414db28ee8e2d7682835.json"}}, {"family": "Van Der Spek", "given": "Ellen", "initials": "E"}, {"family": "van Gelder", "given": "Michel", "initials": "M"}, {"family": "van Kampen", "given": "Roel", "initials": "R"}, {"family": "Varettoni", "given": "Marzia", "initials": "M"}, {"family": "Visentin", "given": "Andrea", "initials": "A"}, {"family": "Vitale", "given": "Candida", "initials": "C", "orcid": "0000-0002-2592-8724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/654bf15e55d64f3cb3e3c43657f57c64.json"}}, {"family": "Wasik-Szczepanek", "given": "Ewa", "initials": "E"}, {"family": "Wr\u00f3bel", "given": "Tomasz", "initials": "T"}, {"family": "San Segundo", "given": "Lucrecia Y\u00e1\u00f1ez", "initials": "LY"}, {"family": "Yassin", "given": "Mohamed", "initials": "M"}, {"family": "Coscia", "given": "Marta", "initials": "M"}, {"family": "Rambaldi", "given": "Alessandro", "initials": "A"}, {"family": "Montserrat", "given": "Emili", "initials": "E"}, {"family": "Fo\u00e0", "given": "Robin", "initials": "R", "orcid": "0000-0002-5021-3026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/058a918147d247a2b0e64bca35a84ef1.json"}}, {"family": "Cuneo", "given": "Antonio", "initials": "A"}, {"family": "Stamatopoulos", "given": "Kostas", "initials": "K", "orcid": "0000-0001-8529-640X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a516e0bd6e842e5ac5c023013d6862a.json"}}, {"family": "Ghia", "given": "Paolo", "initials": "P", "orcid": "0000-0003-3750-7342", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e306a735d4d402886e386e15bfc117a.json"}}], "type": "journal article", "published": "2021-11-01", "journal": {"title": "Leukemia", "issn": "1476-5551", "issn-l": null}, "abstract": "Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41-0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02-1.04; HR = 1.79, 95% CI:1.04-3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.", "doi": "10.1038/s41375-021-01450-8", "pmid": "34725454", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41375-021-01450-8"}, {"db": "pmc", "key": "PMC8559135"}], "notes": [], "created": "2021-11-08T09:05:36.612Z", "modified": "2021-11-08T09:05:37.508Z"}, {"entity": "publication", "iuid": "b08deb7e4eb84c94955fbab22705a606", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b08deb7e4eb84c94955fbab22705a606.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b08deb7e4eb84c94955fbab22705a606"}}, "title": "Antibody response to COVID-19 mRNA vaccine (Comirnaty) in myeloma patients treated with high-dose melphalan and/or immunotherapy.", "authors": [{"family": "Lockmer", "given": "Sandra", "initials": "S"}, {"family": "Uttervall", "given": "Katarina", "initials": "K"}, {"family": "Kashif", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-7545-8548", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5441406f8f5343afa5e2cf8862fafc34.json"}}, {"family": "Sv\u00e4rd", "given": "Carina", "initials": "C"}, {"family": "Malmsten", "given": "Katarina", "initials": "K"}, {"family": "Fletcher-Torres", "given": "Evellyn", "initials": "E"}, {"family": "Alici", "given": "Evren", "initials": "E"}, {"family": "Lund", "given": "Johan", "initials": "J"}, {"family": "Nahi", "given": "Hareth", "initials": "H"}], "type": "letter", "published": "2021-11-01", "journal": {"title": "Am J Hematol", "issn": "0361-8609", "issn-l": null, "volume": "96", "issue": "11", "pages": "E443-E446"}, "abstract": null, "doi": "10.1002/ajh.26348", "pmid": "34524709", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-09-20T06:20:49.999Z", "modified": "2021-11-29T06:14:03.414Z"}, {"entity": "publication", "iuid": "ee59d1bd5bd64046968130fc3e8c53d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee59d1bd5bd64046968130fc3e8c53d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee59d1bd5bd64046968130fc3e8c53d4"}}, "title": "A trans-national examination of the impact of the COVID-19 pandemic on abortion requests through a telemedicine service", "authors": [{"family": "van Ooijen", "given": "Li\u00ebn Trudi", "initials": "LT"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}, {"family": "Gomperts", "given": "Rebecca", "initials": "R"}, {"family": "Waltz", "given": "Mitzi", "initials": "M", "orcid": "0000-0002-9089-2545", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/afe1d32b56984165980321020e20b071.json"}}], "type": "journal-article", "published": "2021-11-01", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-1991", "pages": "bmjsrh-2021-201159", "issn-l": null}, "abstract": null, "doi": "10.1136/bmjsrh-2021-201159", "pmid": null, "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-11-02T15:46:57.720Z", "modified": "2021-11-02T15:46:57.782Z"}, {"entity": "publication", "iuid": "f77db87c3a68476492f41c818af91eb0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f77db87c3a68476492f41c818af91eb0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f77db87c3a68476492f41c818af91eb0"}}, "title": "Virological and immunological features of SARS-COV-2 infected children with distinct symptomatology.", "authors": [{"family": "Cotugno", "given": "Nicola", "initials": "N"}, {"family": "Ruggiero", "given": "Alessandra", "initials": "A"}, {"family": "Pascucci", "given": "Giuseppe Rubens", "initials": "GR"}, {"family": "Bonfante", "given": "Francesco", "initials": "F"}, {"family": "Petrara", "given": "Maria Raffaella", "initials": "MR"}, {"family": "Pighi", "given": "Chiara", "initials": "C"}, {"family": "Cifaldi", "given": "Loredana", "initials": "L"}, {"family": "Zangari", "given": "Paola", "initials": "P"}, {"family": "Bernardi", "given": "Stefania", "initials": "S"}, {"family": "Cursi", "given": "Laura", "initials": "L"}, {"family": "Santilli", "given": "Veronica", "initials": "V"}, {"family": "Manno", "given": "Emma Concetta", "initials": "EC"}, {"family": "Amodio", "given": "Donato", "initials": "D"}, {"family": "Linardos", "given": "Giulia", "initials": "G"}, {"family": "Piccioni", "given": "Livia", "initials": "L"}, {"family": "Barbieri", "given": "Maria Antonietta", "initials": "MA"}, {"family": "Perrotta", "given": "Daniela", "initials": "D"}, {"family": "Campana", "given": "Andrea", "initials": "A"}, {"family": "Don\u00e0", "given": "Daniele", "initials": "D"}, {"family": "Giaquinto", "given": "Carlo", "initials": "C"}, {"family": "CACTUS Study Team", "given": "", "initials": ""}, {"family": "Concato", "given": "Carlo", "initials": "C"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "Rossi", "given": "Paolo", "initials": "P"}, {"family": "De Rossi", "given": "Anita", "initials": "A"}, {"family": "Palma", "given": "Paolo", "initials": "P", "orcid": "0000-0002-3066-4719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36e1a02e86a142c2b2d131154fb46f1c.json"}}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Pediatr Allergy Immunol", "issn": "1399-3038", "issn-l": null, "volume": "32", "issue": "8", "pages": "1833-1842"}, "abstract": "Although SARS-CoV-2 immunizations have started in most countries, children are not currently included in the vaccination programs; thus, it remains crucial to define their anti-SARS-CoV-2 immune response in order to minimize the risk for other epidemic waves. This study sought to provide a description of the virology ad anti-SARS-CoV-2 immunity in children with distinct symptomatology.\n\nBetween March and July 2020, we recruited 15 SARS-CoV-2 asymptomatic (AS) and 51 symptomatic (SY) children, stratified according to WHO clinical classification. We measured SARS-CoV-2 viral load using ddPCR and qPCR in longitudinally collected nasopharyngeal swab samples. To define anti-SARS-CoV-2 antibodies, we measured neutralization activity and total IgG load (DiaSorin). We also evaluated antigen-specific B and CD8+T cells, using a labeled S1+S2 protein and ICAM expression, respectively. Plasma protein profiling was performed with Olink.\n\nVirological profiling showed that AS patients had lower viral load at diagnosis (p = .004) and faster virus clearance (p = .0002) compared with SY patients. Anti-SARS-CoV-2 humoral and cellular response did not appear to be associated with the presence of symptoms. AS and SY patients showed similar titers of SARS-CoV-2 IgG, levels of neutralizing activity, and frequency of Ag-specific B and CD8+ T cells, whereas pro-inflammatory plasma protein profile was found to be associated with symptomatology.\n\nWe demonstrated the development of anti-SARS-CoV-2 humoral and cellular response with any regard to symptomatology, suggesting the ability of both SY and AS patients to contribute toward herd immunity. The virological profiling of AS patients suggested that they have lower virus load associated with faster virus clearance.", "doi": "10.1111/pai.13585", "pmid": "34174102", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8420243"}], "notes": [], "created": "2021-06-28T17:53:46.908Z", "modified": "2023-06-19T15:17:49.739Z"}, {"entity": "publication", "iuid": "2bbb4b1d4816465e817881ddb995850c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2bbb4b1d4816465e817881ddb995850c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2bbb4b1d4816465e817881ddb995850c"}}, "title": "The impact of public health interventions in the Nordic countries during the first year of SARS-CoV-2 transmission and evolution.", "authors": [{"family": "Duchene", "given": "Sebastian", "initials": "S"}, {"family": "Featherstone", "given": "Leo", "initials": "L"}, {"family": "Freiesleben de Blasio", "given": "Birgitte", "initials": "B"}, {"family": "Holmes", "given": "Edward C", "initials": "EC"}, {"family": "Bohlin", "given": "Jon", "initials": "J"}, {"family": "Pettersson", "given": "John H-O", "initials": "JH"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "44", "issn-l": null}, "abstract": "BackgroundMany countries have attempted to mitigate and control COVID-19 through non-pharmaceutical interventions, particularly with the aim of reducing population movement and contact. However, it remains unclear how the different control strategies impacted the local phylodynamics of the causative SARS-CoV-2 virus.AimWe aimed to assess the duration of chains of virus transmission within individual countries and the extent to which countries exported viruses to their geographical neighbours.MethodsWe analysed complete SARS-CoV-2 genomes to infer the relative frequencies of virus importation and exportation, as well as virus transmission dynamics, in countries of northern Europe. We examined virus evolution and phylodynamics in Denmark, Finland, Iceland, Norway and Sweden during the first year of the COVID-19 pandemic.ResultsThe Nordic countries differed markedly in the invasiveness of control strategies, which we found reflected in transmission chain dynamics. For example, Sweden, which compared with the other Nordic countries relied more on recommendation-based rather than legislation-based mitigation interventions, had transmission chains that were more numerous and tended to have more cases. This trend increased over the first 8 months of 2020. Together with Denmark, Sweden was a net exporter of SARS-CoV-2. Norway and Finland implemented legislation-based interventions; their transmission chain dynamics were in stark contrast to their neighbouring country Sweden.ConclusionSweden constituted an epidemiological and evolutionary refugium that enabled the virus to maintain active transmission and spread to other geographical locations. Our analysis reveals the utility of genomic surveillance where monitoring of active transmission chains is a key metric.", "doi": "10.2807/1560-7917.ES.2021.26.44.2001996", "pmid": "34738512", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8569925"}], "notes": [], "created": "2021-11-08T09:17:03.828Z", "modified": "2021-11-26T15:40:09.852Z"}, {"entity": "publication", "iuid": "fe9e07f2554c481b8ee7ea06b75e911f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fe9e07f2554c481b8ee7ea06b75e911f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fe9e07f2554c481b8ee7ea06b75e911f"}}, "title": "Risk of SARS-CoV-2 exposure among hospital healthcare workers in relation to patient contact and type of care.", "authors": [{"family": "Klevebro", "given": "Susanna", "initials": "S", "orcid": "0000-0002-1261-6502", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e192d615f8648c0ae28b5ccaf1d6803.json"}}, {"family": "Bahram", "given": "Fuad", "initials": "F"}, {"family": "Elfstr\u00f6m", "given": "K Miriam", "initials": "KM"}, {"family": "Hellberg", "given": "Ulrika", "initials": "U"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Merid", "given": "Simon Kebede", "initials": "SK"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Tornvall", "given": "Per", "initials": "P"}, {"family": "Wang", "given": "Gang", "initials": "G"}, {"family": "Conneryd Lundgren", "given": "Kalle", "initials": "K"}, {"family": "Ponzer", "given": "Sari", "initials": "S"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E", "orcid": "0000-0002-8248-0663", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58e96082947e4752a23f322e42754097.json"}}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": "49", "issue": "7", "pages": "707-712"}, "abstract": "We aimed to assess prevalence of IgG antibodies to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and factors associated with seropositivity in a large cohort of healthcare workers (HCWs).\n\nFrom 11 May until 11 June 2020, 3981 HCWs at a large Swedish emergency care hospital provided serum samples and questionnaire data. Presence of IgG antibodies to SARS-CoV-2 was measured as an indicator of SARS-CoV-2 exposure.\n\nThe total seroprevalence was 18% and increased during the study period. Among the seropositive HCWs, 11% had been entirely asymptomatic. Participants who worked with COVID-19 patients had higher odds for seropositivity: adjusted odds ratio 1.96 (95% confidence intervals 1.59-2.42). HCWs from three of the departments managing COVID-19 patients had significantly higher seroprevalences, whereas the prevalence among HCWs from the intensive care unit (also managing COVID-19 patients) was significantly lower.\n\nHCWs in contact with SARS-CoV-2 infected patients had a variable, but on average higher, likelihood for SARS-CoV-2 infections.", "doi": "10.1177/14034948211022434", "pmid": "34148454", "labels": {"Funder: KAW/SciLifeLab": null, "Research Area: High-throughput and high-content serology": null, "Funder: VR": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8521364"}], "notes": [], "created": "2021-01-29T17:26:04.393Z", "modified": "2023-06-19T15:25:12.116Z"}, {"entity": "publication", "iuid": "24f0afc328f44bff9346ba4f3046ff91", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24f0afc328f44bff9346ba4f3046ff91.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24f0afc328f44bff9346ba4f3046ff91"}}, "title": "Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021.", "authors": [{"family": "Benschop", "given": "Kimberley Sm", "initials": "KS"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Anton", "given": "Andres", "initials": "A"}, {"family": "Andr\u00e9s", "given": "Cristina", "initials": "C"}, {"family": "Aranzamendi", "given": "Maitane", "initials": "M"}, {"family": "Armannsd\u00f3ttir", "given": "Brynja", "initials": "B"}, {"family": "Bailly", "given": "Jean-Luc", "initials": "JL"}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Baldvinsd\u00f3ttir", "given": "Gu\u00f0r\u00fan Erna", "initials": "GE"}, {"family": "Beard", "given": "Stuart", "initials": "S"}, {"family": "Berginc", "given": "Natasa", "initials": "N"}, {"family": "B\u00f6ttcher", "given": "Sindy", "initials": "S"}, {"family": "Blomqvist", "given": "Soile", "initials": "S"}, {"family": "Bubba", "given": "Laura", "initials": "L"}, {"family": "Calvo", "given": "Cristina", "initials": "C"}, {"family": "Cabrerizo", "given": "Maria", "initials": "M"}, {"family": "Cavallero", "given": "Annalisa", "initials": "A"}, {"family": "Celma", "given": "Cristina", "initials": "C"}, {"family": "Ceriotti", "given": "Ferruccio", "initials": "F"}, {"family": "Costa", "given": "In\u00eas", "initials": "I"}, {"family": "Cottrell", "given": "Simon", "initials": "S"}, {"family": "Del Cuerpo", "given": "Margarita", "initials": "M"}, {"family": "Dean", "given": "Jonathan", "initials": "J"}, {"family": "Dembinski", "given": "Jennifer L", "initials": "JL"}, {"family": "Diedrich", "given": "Sabine", "initials": "S"}, {"family": "Diez-Domingo", "given": "Javier", "initials": "J"}, {"family": "Dorenberg", "given": "DagnyHaug", "initials": "D"}, {"family": "Duizer", "given": "Erwin", "initials": "E"}, {"family": "Dyrdak", "given": "Robert", "initials": "R"}, {"family": "Fanti", "given": "Diana", "initials": "D"}, {"family": "Farkas", "given": "Agnes", "initials": "A"}, {"family": "Feeney", "given": "Susan", "initials": "S"}, {"family": "Flipse", "given": "Jacky", "initials": "J"}, {"family": "De Gascun", "given": "Cillian", "initials": "C"}, {"family": "Galli", "given": "Cristina", "initials": "C"}, {"family": "Georgieva", "given": "Irina", "initials": "I"}, {"family": "Gifford", "given": "Laura", "initials": "L"}, {"family": "Guiomar", "given": "Raquel", "initials": "R"}, {"family": "H\u00f6nemann", "given": "Mario", "initials": "M"}, {"family": "Ikonen", "given": "Niina", "initials": "N"}, {"family": "Jeanno\u00ebl", "given": "Marion", "initials": "M"}, {"family": "Josset", "given": "Laurence", "initials": "L"}, {"family": "Keeren", "given": "Kathrin", "initials": "K"}, {"family": "L\u00f3pez-Labrador", "given": "F Xavier", "initials": "FX"}, {"family": "Maier", "given": "Melanie", "initials": "M"}, {"family": "McKenna", "given": "James", "initials": "J"}, {"family": "Meijer", "given": "Adam", "initials": "A"}, {"family": "Mengual-Chuli\u00e1", "given": "Beatriz", "initials": "B"}, {"family": "Midgley", "given": "Sofie E", "initials": "SE"}, {"family": "Mirand", "given": "Audrey", "initials": "A"}, {"family": "Montes", "given": "Milagrosa", "initials": "M"}, {"family": "Moore", "given": "Catherine", "initials": "C"}, {"family": "Morley", "given": "Ursula", "initials": "U"}, {"family": "Murk", "given": "Jean-Luc", "initials": "JL"}, {"family": "Nikolaeva-Glomb", "given": "Lubomira", "initials": "L"}, {"family": "Numanovic", "given": "Sanela", "initials": "S"}, {"family": "Oggioni", "given": "Massimo", "initials": "M"}, {"family": "Palminha", "given": "Paula", "initials": "P"}, {"family": "Pariani", "given": "Elena", "initials": "E"}, {"family": "Pellegrinelli", "given": "Laura", "initials": "L"}, {"family": "Piralla", "given": "Antonio", "initials": "A"}, {"family": "Pietsch", "given": "Corinna", "initials": "C"}, {"family": "Pi\u00f1eiro", "given": "Luis", "initials": "L"}, {"family": "Rabella", "given": "N\u00faria", "initials": "N"}, {"family": "Rainetova", "given": "Petra", "initials": "P"}, {"family": "Uceda Renteria", "given": "Sara Colonia", "initials": "SC"}, {"family": "Romero", "given": "Mar\u00eda P", "initials": "MP"}, {"family": "Reynders", "given": "Marijke", "initials": "M"}, {"family": "Roorda", "given": "Lieuwe", "initials": "L"}, {"family": "Savolainen-Kopra", "given": "Carita", "initials": "C"}, {"family": "Schuffenecker", "given": "Isabelle", "initials": "I"}, {"family": "Soynova", "given": "Aysa", "initials": "A"}, {"family": "Swanink", "given": "Caroline Ma", "initials": "CM"}, {"family": "Ursic", "given": "Tina", "initials": "T"}, {"family": "Verweij", "given": "Jaco J", "initials": "JJ"}, {"family": "Vila", "given": "Jorgina", "initials": "J"}, {"family": "Vuorinen", "given": "Tytti", "initials": "T"}, {"family": "Simmonds", "given": "Peter", "initials": "P"}, {"family": "Fischer", "given": "Thea K", "initials": "TK"}, {"family": "Harvala", "given": "Heli", "initials": "H"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "45", "issn-l": null}, "abstract": "We report a rapid increase in enterovirus D68 (EV-D68) infections, with 139 cases reported from eight European countries between 31 July and 14 October 2021. This upsurge is in line with the seasonality of EV-D68 and was presumably stimulated by the widespread reopening after COVID-19 lockdown. Most cases were identified in September, but more are to be expected in the coming months. Reinforcement of clinical awareness, diagnostic capacities and surveillance of EV-D68 is urgently needed in Europe.", "doi": "10.2807/1560-7917.ES.2021.26.45.2100998", "pmid": "34763750", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8646978"}], "notes": [], "created": "2021-11-26T15:15:11.761Z", "modified": "2023-06-19T14:43:53.882Z"}, {"entity": "publication", "iuid": "e686547fbd854c61b8cef013d5938d3b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e686547fbd854c61b8cef013d5938d3b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e686547fbd854c61b8cef013d5938d3b"}}, "title": "Predictors of severe COVID-19 in a registry-based Swedish cohort of patients with COPD", "authors": [{"family": "Stridsman", "given": "Caroline", "initials": "C", "orcid": "0000-0001-6622-3838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e2fc66fb68748eba5a7f8eb93c5ff3f.json"}}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW", "orcid": "0000-0002-4387-4096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bb5d1f761ef48c4837ed4f984717f0e.json"}}, {"family": "Konradsen", "given": "Jon R", "initials": "JR", "orcid": "0000-0001-7745-8624", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12c585ede9a64cb593a6dc5dbd5f02ed.json"}}, {"family": "Axelsson Fisk", "given": "Sten", "initials": "S"}, {"family": "Pedroletti", "given": "Christophe", "initials": "C"}, {"family": "Sj\u00f6\u00f6", "given": "Yvonne", "initials": "Y"}, {"family": "Syk", "given": "J\u00f6rgen", "initials": "J"}, {"family": "Sterner", "given": "Therese", "initials": "T"}, {"family": "Lindberg", "given": "Anne", "initials": "A", "orcid": "0000-0002-3292-7471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc3222a49f994e7cb8812c32e24c3a73.json"}}, {"family": "Tuns\u00e4ter", "given": "Alf", "initials": "A"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ekberg-Jansson", "given": "Ann", "initials": "A"}, {"family": "Karlsson Sundbaum", "given": "Johanna", "initials": "J"}], "type": "journal-article", "published": "2021-11-00", "journal": {"title": "Eur Respir J", "issn": "0903-1936", "issn-l": null, "volume": "58", "issue": "5", "pages": "2101920"}, "abstract": null, "doi": "10.1183/13993003.01920-2021", "pmid": "34413151", "labels": {"Type: Journal article": null, "Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [], "notes": [], "created": "2021-08-20T12:36:17.060Z", "modified": "2021-12-06T14:30:39.904Z"}, {"entity": "publication", "iuid": "3acc45d672b949c2bdc96cff5a2f37e9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3acc45d672b949c2bdc96cff5a2f37e9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3acc45d672b949c2bdc96cff5a2f37e9"}}, "title": "Plasma endostatin correlates with hypoxia and mortality in COVID-19-associated acute respiratory failure.", "authors": [{"family": "Asif", "given": "Sana", "initials": "S", "orcid": "0000-0001-7924-0936", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/336d0f6c0519467b848a7c05790665d8.json"}}, {"family": "Ruge", "given": "Thoralph", "initials": "T", "orcid": "0000-0002-1170-5183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d6fd0aae4374003924cfcc1acd004a9.json"}}, {"family": "Larsson", "given": "Anders", "initials": "A", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2be858ab604743b72383dfdcd14689.json"}}, {"family": "Anderberg", "given": "Sara B\u00fclow", "initials": "SB"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Fritiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}], "type": "clinical trial", "published": "2021-11-00", "journal": {"title": "Biomark Med", "issn": "1752-0371", "volume": "15", "issue": "16", "pages": "1509-1517", "issn-l": null}, "abstract": "Background: The contribution of endothelial injury in the pathogenesis of COVID-19-associated acute respiratory distress syndrome (ARDS) and resulting respiratory failure remains unclear. Plasma endostatin, an endogenous inhibitor of angiogenesis and endothelial dysfunction is upregulated during hypoxia, inflammation and progress of pulmonary disease. Aim: To investigate if plasma endostatin is associated to hypoxia, inflammation and 30-day mortality in patients with severe COVID-19 infection. Method: Samples for blood analysis and plasma endostatin quantification were collected from adult patients with ongoing COVID-19 (n = 109) on admission to intensive care unit (day 1). Demographic characteristics and 30-day mortality data were extracted from medical records. The ability of endostatin to predict mortality was analyzed using receiving operating characteristics and Kaplan-Meier analysis with a cutoff at 46.2 ng/ml was used to analyze the association to survival. Results: Plasma endostatin levels correlated with; PaO2/FiO2 (r = -0.3, p < 0.001), arterial oxygen tension (r = -0.2, p = 0.01), lactate (r = 0.2, p = 0.04), C-reactive protein (r = 0.2, p = 0.04), ferritin (r = 0.2, p = 0.09), D-dimer (r = 0.2, p = 0.08) and IL-6 (r = 0.4, p < 0.001). Nonsurvivors at 30 days had higher plasma endostatin levels than survivors (72 \u00b1 26 vs 56 \u00b1 16 ng/ml, p = 0.01). Receiving operating characteristic curve (area under the curve 0.7) showed that plasma endostatin >46.2 ng/ml predicts mortality with a sensitivity of 92% and specificity of 71%. In patients with plasma endostatin >46.2 ng/ml probability of survival was lower (p = 0.02) in comparison to those with endostatin <46.2 ng/ml. Conclusion: Our results suggest that plasma endostatin is an early biomarker for disease severity in COVID-19.", "doi": "10.2217/bmm-2021-0111", "pmid": "34668393", "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC8547279"}], "notes": [], "created": "2021-10-21T04:38:51.737Z", "modified": "2021-12-12T18:10:59.396Z"}, {"entity": "publication", "iuid": "fdfafb1234274fd1ad40058ec2ffc6d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fdfafb1234274fd1ad40058ec2ffc6d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fdfafb1234274fd1ad40058ec2ffc6d0"}}, "title": "Meta-analysis of the clinical performance of commercial SARS-CoV-2 nucleic acid and antibody tests up to 22 August 2020.", "authors": [{"family": "Van Walle", "given": "Ivo", "initials": "I"}, {"family": "Leitmeyer", "given": "Katrin", "initials": "K"}, {"family": "Broberg", "given": "Eeva K", "initials": "EK"}, {"family": "European COVID-19 microbiological laboratories group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "45", "issn-l": null}, "abstract": "BackgroundReliable testing for SARS-CoV-2 is key for the management of the COVID-19 pandemic.AimWe estimate diagnostic accuracy for nucleic acid and antibody tests 5 months into the COVID-19 pandemic, and compare with manufacturer-reported accuracy.MethodsWe reviewed the clinical performance of SARS-CoV-2 nucleic acid and antibody tests based on 93,757 test results from 151 published studies and 20,205 new test results from 12 countries in the European Union and European Economic Area (EU/EEA).ResultsPooling the results and considering only results with 95% confidence interval width \u2264 5%, we found four nucleic acid tests, including one point-of-care test and three antibody tests, with a clinical sensitivity \u2265 95% for at least one target population (hospitalised, mild or asymptomatic, or unknown). Nine nucleic acid tests and 25 antibody tests, 12 of them point-of-care tests, had a clinical specificity of \u2265 98%. Three antibody tests achieved both thresholds. Evidence for nucleic acid point-of-care tests remains scarce at present, and sensitivity varied substantially. Study heterogeneity was low for eight of 14 sensitivity and 68 of 84 specificity results with confidence interval width \u2264 5%, and lower for nucleic acid tests than antibody tests. Manufacturer-reported clinical performance was significantly higher than independently assessed in 11 of 32 and four of 34 cases, respectively, for sensitivity and specificity, indicating a need for improvement in this area.ConclusionContinuous monitoring of clinical performance within more clearly defined target populations is needed.", "doi": "10.2807/1560-7917.ES.2021.26.45.2001675", "pmid": "34763752", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T15:14:55.635Z", "modified": "2021-11-26T15:14:55.648Z"}, {"entity": "publication", "iuid": "16b928a1028b4122b7001d154096d8d3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16b928a1028b4122b7001d154096d8d3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16b928a1028b4122b7001d154096d8d3"}}, "title": "Mental health and well-being during COVID-19 lockdown: A survey case report of high-level male and female players of an Italian Serie A football club.", "authors": [{"family": "Ivarsson", "given": "Andreas", "initials": "A", "orcid": "0000-0002-8987-5975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e77e48568e184548a5da063cb6b339be.json"}}, {"family": "McCall", "given": "Alan", "initials": "A", "orcid": "0000-0003-3780-8153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/128f2983992a4f9b95332e3a130c9aaa.json"}}, {"family": "Mutch", "given": "Stephen", "initials": "S"}, {"family": "Giuliani", "given": "Alessia", "initials": "A"}, {"family": "Bassetto", "given": "Rita", "initials": "R"}, {"family": "Fanchini", "given": "Maurizio", "initials": "M"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Sci Med Footb", "issn": "2473-4446", "volume": "5", "issue": "sup1", "pages": "70-75", "issn-l": null}, "abstract": "To describe high-level footballers' levels and changes in mental health and well-being throughout a 8-week period of lockdown and restricted training during the COVID-19 pandemic.\n\nOne-hundred and one players belonging to four teams (women's and men's, first and U19 teams) of the same Italian Serie A club participated in the study. Data were collected through an online questionnaire, and administered at 2, 3, 5, 7 and 9 weeks after the start of the lockdown . Well-being, positive and negative affects measurements were examined.\n\nAcross the five measures, 36% of players reported clinical levels in depressive symptoms (scores \u226450) on at least one occasion. Thirteen percent of the players reported clinical levels on > 50% of the occasions. There was a decrease in depressive symptoms and negative affects over the period. No change was found in positive affects.\n\nHigh number of players reportedclinical levels of depressive symptoms compared to what was found previously in high-level athletes. The number decrease during the 8-week period. A similar trend was found for negative affects.Despite a higher prevalence in depressive symptoms earlier during lockdown, this improved as players progressed towards fewer restrictions.", "doi": "10.1080/24733938.2021.1962540", "pmid": "35077318", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-26T08:23:20.767Z", "modified": "2022-01-26T08:23:20.850Z"}, {"entity": "publication", "iuid": "b0c2ec5ca4eb4f45a757c95cf83e92ad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b0c2ec5ca4eb4f45a757c95cf83e92ad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b0c2ec5ca4eb4f45a757c95cf83e92ad"}}, "title": "Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia: The COVID STEROID randomised, placebo-controlled trial.", "authors": [{"family": "Munch", "given": "Marie Warrer", "initials": "MW", "orcid": "0000-0003-1127-9599", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd56f64f991042da935f6f3836e087b0.json"}}, {"family": "Meyhoff", "given": "Tine Sylvest", "initials": "TS", "orcid": "0000-0002-1840-1596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/766fe5fd044944faabf6a96e8d6a72f0.json"}}, {"family": "Helleberg", "given": "Marie", "initials": "M"}, {"family": "Kjaer", "given": "Maj-Brit N\u00f8rregaard", "initials": "MN", "orcid": "0000-0002-6536-0504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df8fa07399b448a5b689089e505dab58.json"}}, {"family": "Granholm", "given": "Anders", "initials": "A"}, {"family": "Hjorts\u00f8", "given": "Carl Johan Steensen", "initials": "CJS", "orcid": "0000-0003-0413-9715", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/669b4f267a51406e9f074db4ba66629f.json"}}, {"family": "Jensen", "given": "Thomas Steen", "initials": "TS"}, {"family": "M\u00f8ller", "given": "Morten Hylander", "initials": "MH", "orcid": "0000-0002-6378-9673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1cf88aaa5c9436a8e70ddfe39cfe4e8.json"}}, {"family": "Hjortrup", "given": "Peter Buhl", "initials": "PB"}, {"family": "Wetterslev", "given": "Mik", "initials": "M", "orcid": "0000-0002-8798-1133", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9848ee20a294a7da581dec0d23383c7.json"}}, {"family": "Vesterlund", "given": "Gitte Kingo", "initials": "GK", "orcid": "0000-0001-5221-3938", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6eb5ff4bc5054887bfac267b8c8af411.json"}}, {"family": "Russell", "given": "Lene", "initials": "L"}, {"family": "J\u00f8rgensen", "given": "Vibeke Lind", "initials": "VL"}, {"family": "Kristiansen", "given": "Klaus Tjelle", "initials": "KT"}, {"family": "Benfield", "given": "Thomas", "initials": "T"}, {"family": "Ulrik", "given": "Charlotte Suppli", "initials": "CS"}, {"family": "Andreasen", "given": "Anne Sofie", "initials": "AS"}, {"family": "Bestle", "given": "Morten Heiberg", "initials": "MH"}, {"family": "Poulsen", "given": "Lone Musaeus", "initials": "LM"}, {"family": "Hildebrandt", "given": "Thomas", "initials": "T"}, {"family": "Knudsen", "given": "Lene Surland", "initials": "LS"}, {"family": "M\u00f8ller", "given": "Anders", "initials": "A"}, {"family": "S\u00f8lling", "given": "Christoffer Grant", "initials": "CG"}, {"family": "Br\u00f8chner", "given": "Anne Craveiro", "initials": "AC"}, {"family": "Rasmussen", "given": "Bodil Steen", "initials": "BS", "orcid": "0000-0003-2190-145X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa66146077394afea60f71d4be6daf06.json"}}, {"family": "Nielsen", "given": "Henrik", "initials": "H"}, {"family": "Christensen", "given": "Steffen", "initials": "S"}, {"family": "Str\u00f8m", "given": "Thomas", "initials": "T"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Wahlin", "given": "Rebecka Rubenson", "initials": "RR"}, {"family": "Jakob", "given": "Stephan M", "initials": "SM"}, {"family": "Cioccari", "given": "Luca", "initials": "L"}, {"family": "Venkatesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Hammond", "given": "Naomi", "initials": "N"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Myatra", "given": "Sheila Nainan", "initials": "SN"}, {"family": "Jensen", "given": "Marie Qvist", "initials": "MQ"}, {"family": "Leistner", "given": "Jens Wolfgang", "initials": "JW"}, {"family": "Mikkelsen", "given": "Vibe Sommer", "initials": "VS", "orcid": "0000-0001-9518-0566", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e265103e395f42dba402abee098091bd.json"}}, {"family": "Svenningsen", "given": "Jens S", "initials": "JS"}, {"family": "Laursen", "given": "Signe Bj\u00f8rn", "initials": "SB"}, {"family": "Hatley", "given": "Emma Victoria", "initials": "EV"}, {"family": "Kristensen", "given": "Camilla Meno", "initials": "CM"}, {"family": "Al-Alak", "given": "Ali", "initials": "A"}, {"family": "Clapp", "given": "Esben", "initials": "E"}, {"family": "Jonassen", "given": "Trine Bak", "initials": "TB"}, {"family": "Bjerregaard", "given": "Caroline L\u00f8kke", "initials": "CL"}, {"family": "\u00d8sterby", "given": "Niels Christian Haubjerg", "initials": "NCH"}, {"family": "Jespersen", "given": "Mette Mindedahl", "initials": "MM"}, {"family": "Abou-Kassem", "given": "Dalia", "initials": "D"}, {"family": "Lassen", "given": "Mathilde Languille", "initials": "ML"}, {"family": "Zaabalawi", "given": "Reem", "initials": "R"}, {"family": "Daoud", "given": "Mohammed Mahmoud", "initials": "MM"}, {"family": "Abdi", "given": "Suhayb", "initials": "S"}, {"family": "Meier", "given": "Nick", "initials": "N"}, {"family": "la Cour", "given": "Kirstine", "initials": "K"}, {"family": "Derby", "given": "Cecilie Bauer", "initials": "CB"}, {"family": "Damlund", "given": "Birka Ravnholt", "initials": "BR"}, {"family": "Laigaard", "given": "Jens", "initials": "J"}, {"family": "Andersen", "given": "Lene Lund", "initials": "LL"}, {"family": "Mikkelsen", "given": "Johan", "initials": "J"}, {"family": "Jensen", "given": "Jeppe Lundholm Stadarfeld", "initials": "JLS", "orcid": "0000-0001-9247-8623", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/072014c0fcb84d5992707959e11dad7f.json"}}, {"family": "Rasmussen", "given": "Anders H\u00f8rby", "initials": "AH"}, {"family": "Arnerl\u00f6v", "given": "Emil", "initials": "E"}, {"family": "Lykke", "given": "Mathilde", "initials": "M"}, {"family": "Holst-Hansen", "given": "Mikkel Zacharias Bystrup", "initials": "MZB"}, {"family": "T\u00f8stesen", "given": "Boris Wied", "initials": "BW"}, {"family": "Schwab", "given": "Janne", "initials": "J"}, {"family": "Madsen", "given": "Emilie Kabel", "initials": "EK"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Lange", "given": "Theis", "initials": "T"}, {"family": "Perner", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": "65", "issue": "10", "pages": "1421-1430"}, "abstract": "In the early phase of the pandemic, some guidelines recommended the use of corticosteroids for critically ill patients with COVID-19, whereas others recommended against the use despite lack of firm evidence of either benefit or harm. In the COVID STEROID trial, we aimed to assess the effects of low-dose hydrocortisone on patient-centred outcomes in adults with COVID-19 and severe hypoxia.\n\nIn this multicentre, parallel-group, placebo-controlled, blinded, centrally randomised, stratified clinical trial, we randomly assigned adults with confirmed COVID-19 and severe hypoxia (use of mechanical ventilation or supplementary oxygen with a flow of at least 10 L/min) to either hydrocortisone (200 mg/d) vs a matching placebo for 7 days or until hospital discharge. The primary outcome was the number of days alive without life support at day 28 after randomisation.\n\nThe trial was terminated early when 30 out of 1000 participants had been enrolled because of external evidence indicating benefit from corticosteroids in severe COVID-19. At day 28, the median number of days alive without life support in the hydrocortisone vs placebo group were 7 vs 10 (adjusted mean difference: -1.1 days, 95% CI -9.5 to 7.3, P = .79); mortality was 6/16 vs 2/14; and the number of serious adverse reactions 1/16 vs 0/14.\n\nIn this trial of adults with COVID-19 and severe hypoxia, we were unable to provide precise estimates of the benefits and harms of hydrocortisone as compared with placebo as only 3% of the planned sample size were enrolled.\n\nClinicalTrials.gov: NCT04348305. European Union Drug Regulation Authorities Clinical Trials (EudraCT) Database: 2020-001395-15.", "doi": "10.1111/aas.13941", "pmid": "34138478", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8441888"}, {"db": "ClinicalTrials.gov", "key": "NCT04348305", "description": "European Union Drug Regulation Authorities Clinical Trials (EudraCT) Database: 2020-001395-15"}], "notes": [], "created": "2021-06-28T18:40:57.689Z", "modified": "2021-11-18T16:16:11.068Z"}, {"entity": "publication", "iuid": "dda5b431d9a64e4b8ed2ae8c5297c020", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dda5b431d9a64e4b8ed2ae8c5297c020.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dda5b431d9a64e4b8ed2ae8c5297c020"}}, "title": "Labor market effects of COVID-19 in Sweden and its neighbors: Evidence from administrative data.", "authors": [{"family": "Juranek", "given": "Steffen", "initials": "S"}, {"family": "Paetzold", "given": "J\u00f6rg", "initials": "J"}, {"family": "Winner", "given": "Hannes", "initials": "H"}, {"family": "Zoutman", "given": "Floris", "initials": "F"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Kyklos (Oxford)", "issn": "0023-5962", "issn-l": null, "volume": "74", "issue": "4", "pages": "512-526"}, "abstract": "This paper studies the labor market effects of non-pharmaceutical interventions (NPIs) to combat the COVID-19 pandemic. We focus on the Nordic countries which showed one of the highest variations in NPIs despite having similar community spread of COVID-19 at the onset of the pandemic: While Denmark, Finland and Norway imposed strict measures ('lockdowns'), Sweden decided for much lighter restrictions. Empirically, we use novel administrative data on weekly new unemployment and furlough spells from all 56 regions of the Nordic countries to compare the labor market outcomes of Sweden with the ones of its neighbors. Our evidence suggests that the labor markets of all countries were severely hit by the pandemic, although Sweden performed slightly better than its neighbors. Specifically, we find the worsening of the Swedish labor market to occur around 2 to 3 weeks later than in the other Nordic countries, and that its cumulative sum of new unemployment and furlough spells remained significantly lower (about 20-25%) during the time period of our study (up to week 21 of 2020).", "doi": "10.1111/kykl.12282", "pmid": "34908590", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "KYKL12282"}, {"db": "pmc", "key": "PMC8661996"}], "notes": [], "created": "2021-12-18T17:51:49.333Z", "modified": "2022-02-17T12:30:17.871Z"}, {"entity": "publication", "iuid": "0bd2b077da9d4a3091509a0596a30967", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0bd2b077da9d4a3091509a0596a30967.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0bd2b077da9d4a3091509a0596a30967"}}, "title": "How did micro-mobility change in response to COVID-19 pandemic? A case study based on spatial-temporal-semantic analytics", "authors": [{"family": "Li", "given": "Aoyong", "initials": "A", "orcid": "0000-0001-8032-5881", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a4e9267faa04311aafbfebc430a6852.json"}}, {"family": "Zhao", "given": "Pengxiang", "initials": "P"}, {"family": "Haitao", "given": "He", "initials": "H", "orcid": "0000-0002-6371-1358", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fcca1873da74684bda05ab77e5ee9a2.json"}}, {"family": "Mansourian", "given": "Ali", "initials": "A"}, {"family": "Axhausen", "given": "Kay W", "initials": "KW"}], "type": "journal-article", "published": "2021-11-00", "journal": {"title": "Computers, Environment and Urban Systems", "issn": "0198-9715", "volume": "90", "pages": "101703", "issn-l": null}, "abstract": null, "doi": "10.1016/j.compenvurbsys.2021.101703", "pmid": null, "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:52:03.764Z", "modified": "2021-10-11T17:52:03.891Z"}, {"entity": "publication", "iuid": "e050dfe1bcaa4bc998955d2a21416596", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e050dfe1bcaa4bc998955d2a21416596.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e050dfe1bcaa4bc998955d2a21416596"}}, "title": "Health and financial costs of adverse childhood experiences in 28 European countries: a systematic review and meta-analysis.", "authors": [{"family": "Hughes", "given": "Karen", "initials": "K"}, {"family": "Ford", "given": "Kat", "initials": "K"}, {"family": "Bellis", "given": "Mark A", "initials": "MA"}, {"family": "Glendinning", "given": "Freya", "initials": "F"}, {"family": "Harrison", "given": "Emma", "initials": "E"}, {"family": "Passmore", "given": "Jonathon", "initials": "J"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Lancet Public Health", "issn": "2468-2667", "volume": "6", "issue": "11", "pages": "e848-e857", "issn-l": null}, "abstract": "Adverse childhood experiences (ACEs) are associated with increased health risks across the life course. We aimed to estimate the annual health and financial burden of ACEs for 28 European countries.\n\nIn this systematic review and meta-analysis, we searched MEDLINE, CINAHL, PsycINFO, Applied Social Sciences Index and Abstracts, Criminal Justice Databases, and Education Resources Information Center for quantitative studies (published Jan 1, 1990, to Sept 8, 2020) that reported prevalence of ACEs and risks of health outcomes associated with ACEs. Pooled relative risks were calculated for associations between ACEs and harmful alcohol use, smoking, illicit drug use, high body-mass index, depression, anxiety, interpersonal violence, cancer, type 2 diabetes, cardiovascular disease, stroke, and respiratory disease. Country-level ACE prevalence was calculated using available data. Country-level population attributable fractions (PAFs) due to ACEs were generated and applied to 2019 estimates of disability-adjusted life-years. Financial costs (US$ in 2019) were estimated using an adapted human capital approach.\n\nIn most countries, interpersonal violence had the largest PAFs due to ACEs (range 14\u00b77-53\u00b75%), followed by harmful alcohol use (15\u00b77-45\u00b70%), illicit drug use (15\u00b72-44\u00b79%), and anxiety (13\u00b79%-44\u00b78%). Harmful alcohol use, smoking, and cancer had the highest ACE-attributable costs in many countries. Total ACE-attributable costs ranged from $0\u00b71 billion (Montenegro) to $129\u00b74 billion (Germany) and were equivalent to between 1\u00b71% (Sweden and Turkey) and 6\u00b70% (Ukraine) of nations' gross domestic products.\n\nAvailability of ACE data varies widely between countries and country-level estimates cannot be directly compared. However, findings suggest ACEs are associated with major health and financial costs across European countries. The cost of not investing to prevent ACEs must be recognised, particularly as countries look to recover from the COVID-19 pandemic, which interrupted services and education, and potentially increased risk factors for ACEs.\n\nWHO Regional Office for Europe.", "doi": "10.1016/S2468-2667(21)00232-2", "pmid": "34756168", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2468-2667(21)00232-2"}, {"db": "pmc", "key": "PMC8573710"}], "notes": [], "created": "2021-11-26T15:23:07.766Z", "modified": "2021-11-26T15:23:07.780Z"}, {"entity": "publication", "iuid": "a6de81647b9d48ff81db31a531c34ff8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6de81647b9d48ff81db31a531c34ff8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6de81647b9d48ff81db31a531c34ff8"}}, "title": "Evolutionary analysis of the Delta and Delta Plus variants of the SARS-CoV-2 viruses.", "authors": [{"family": "Kannan", "given": "Saathvik R", "initials": "SR"}, {"family": "Spratt", "given": "Austin N", "initials": "AN"}, {"family": "Cohen", "given": "Alisha R", "initials": "AR"}, {"family": "Naqvi", "given": "S Hasan", "initials": "SH"}, {"family": "Chand", "given": "Hitendra S", "initials": "HS"}, {"family": "Quinn", "given": "Thomas P", "initials": "TP"}, {"family": "Lorson", "given": "Christian L", "initials": "CL"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}, {"family": "Singh", "given": "Kamal", "initials": "K"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "J Autoimmun", "issn": "1095-9157", "volume": "124", "pages": "102715", "issn-l": null}, "abstract": "Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been rapidly evolving in the form of new variants. At least eleven known variants have been reported. The objective of this study was to delineate the differences in the mutational profile of Delta and Delta Plus variants. High-quality sequences (n = 1756) of Delta (B.1.617.2) and Delta Plus (AY.1 or B.1.617.2.1) variants were used to determine the prevalence of mutations (\u226520 %) in the entire SARS-CoV-2 genome, their co-existence, and change in prevalence over a period of time. Structural analysis was conducted to get insights into the impact of mutations on antibody binding. A Sankey diagram was generated using phylogenetic analysis coupled with sequence-acquisition dates to infer the migration of the Delta Plus variant and its presence in the United States. The Delta Plus variant had a significant number of high-prevalence mutations (\u226520 %) than in the Delta variant. Signature mutations in Spike (G142D, A222V, and T95I) existed at a more significant percentage in the Delta Plus variant than the Delta variant. Three mutations in Spike (K417N, V70F, and W258L) were exclusively present in the Delta Plus variant. A new mutation was identified in ORF1a (A1146T), which was only present in the Delta Plus variant with ~58 % prevalence. Furthermore, five key mutations (T95I, A222V, G142D, R158G, and K417N) were significantly more prevalent in the Delta Plus than in the Delta variant. Structural analyses revealed that mutations alter the sidechain conformation to weaken the interactions with antibodies. Delta Plus, which first emerged in India, reached the United States through England and Japan, followed by its spread to more than 20 the United States. Based on the results presented here, it is clear that the Delta and Delta Plus variants have unique mutation profiles, and the Delta Plus variant is not just a simple addition of K417N to the Delta variant. Highly correlated mutations may have emerged to keep the structural integrity of the virus.", "doi": "10.1016/j.jaut.2021.102715", "pmid": "34399188", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8354793"}, {"db": "pii", "key": "S0896-8411(21)00123-2"}], "notes": [], "created": "2021-08-17T06:35:35.248Z", "modified": "2023-01-13T14:45:01.860Z"}, {"entity": "publication", "iuid": "45243b8fa33a46138df138172a5df835", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/45243b8fa33a46138df138172a5df835.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/45243b8fa33a46138df138172a5df835"}}, "title": "Estimated number of deaths directly averted in people 60 years and older as a result of COVID-19 vaccination in the WHO European Region, December 2020 to November 2021.", "authors": [{"family": "Mesl\u00e9", "given": "Margaux Mi", "initials": "MM"}, {"family": "Brown", "given": "Jeremy", "initials": "J"}, {"family": "Mook", "given": "Piers", "initials": "P"}, {"family": "Hagan", "given": "Jos\u00e9", "initials": "J"}, {"family": "Pastore", "given": "Roberta", "initials": "R"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Spiteri", "given": "Gianfranco", "initials": "G"}, {"family": "Ravasi", "given": "Giovanni", "initials": "G"}, {"family": "Nicolay", "given": "Nathalie", "initials": "N"}, {"family": "Andrews", "given": "Nick", "initials": "N"}, {"family": "Dykhanovska", "given": "Tetiana", "initials": "T"}, {"family": "Mossong", "given": "Jo\u00ebl", "initials": "J"}, {"family": "Sadkowska-Todys", "given": "Ma\u0142gorzata", "initials": "M"}, {"family": "Nikiforova", "given": "Raina", "initials": "R"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}, {"family": "Mazagatos", "given": "Clara", "initials": "C"}, {"family": "Kyncl", "given": "Jan", "initials": "J"}, {"family": "McMenamin", "given": "Jim", "initials": "J"}, {"family": "Melillo", "given": "Tanya", "initials": "T"}, {"family": "Kaoustou", "given": "Stella", "initials": "S"}, {"family": "L\u00e9vy-Bruhl", "given": "Daniel", "initials": "D"}, {"family": "Haarhuis", "given": "Freek", "initials": "F"}, {"family": "Rich", "given": "Rivka", "initials": "R"}, {"family": "Kall", "given": "Meaghan", "initials": "M"}, {"family": "Nitzan", "given": "Dorit", "initials": "D"}, {"family": "Smallwood", "given": "Catherine", "initials": "C"}, {"family": "Pebody", "given": "Richard G", "initials": "RG"}], "type": "journal article", "published": "2021-11-00", "journal": {"issn": "1560-7917", "volume": "26", "issue": "47", "title": "Euro Surveill", "issn-l": null}, "abstract": "Since December 2019, over 1.5 million SARS-CoV-2-related fatalities have been recorded in the World Health Organization European Region - 90.2% in people \u2265 60 years. We calculated lives saved in this age group by COVID-19 vaccination in 33 countries from December 2020 to November 2021, using weekly reported deaths and vaccination coverage. We estimated that vaccination averted 469,186 deaths (51% of 911,302 expected deaths; sensitivity range: 129,851-733,744; 23-62%). Impact by country ranged 6-93%, largest when implementation was early.", "doi": "10.2807/1560-7917.ES.2021.26.47.2101021", "pmid": "34823641", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8619871"}], "notes": [], "created": "2021-11-26T13:03:12.068Z", "modified": "2021-12-18T18:20:10.012Z"}, {"entity": "publication", "iuid": "729c6621d33d4b269c6ce37008c4ae81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/729c6621d33d4b269c6ce37008c4ae81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/729c6621d33d4b269c6ce37008c4ae81"}}, "title": "Epidemiological comparison of the first and second waves of the COVID-19 pandemic in Nigeria, February 2020-April 2021.", "authors": [{"family": "Akande", "given": "Oluwatosin Wuraola", "initials": "OW", "orcid": "0000-0001-6906-895X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7ce51eb7a0b4a04b6af2802c88e2290.json"}}, {"family": "Elimian", "given": "Kelly Osezele", "initials": "KO", "orcid": "0000-0003-2729-1613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/695dddf720414c3585d35b30184f0178.json"}}, {"family": "Igumbor", "given": "Ehimario", "initials": "E", "orcid": "0000-0002-6313-6031", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff090388bcf945529573cefac01ec72d.json"}}, {"family": "Dunkwu", "given": "Lauryn", "initials": "L"}, {"family": "Kaduru", "given": "Chijioke", "initials": "C"}, {"family": "Olopha", "given": "Olubunmi Omowunmi", "initials": "OO"}, {"family": "Ohanu", "given": "Dabri Olohije", "initials": "DO"}, {"family": "Nwozor", "given": "Lilian", "initials": "L"}, {"family": "Agogo", "given": "Emmanuel", "initials": "E"}, {"family": "Aruna", "given": "Olusola", "initials": "O"}, {"family": "Balogun", "given": "Muhammad Shakir", "initials": "MS"}, {"family": "Aderinola", "given": "Olaolu", "initials": "O"}, {"family": "Ahumibe", "given": "Anthony", "initials": "A"}, {"family": "Arinze", "given": "Chinedu", "initials": "C"}, {"family": "Badaru", "given": "Sikiru Olanrewaju", "initials": "SO"}, {"family": "Nwachukwu", "given": "William", "initials": "W"}, {"family": "Dada", "given": "Augustine Olajide", "initials": "AO"}, {"family": "Erameh", "given": "Cyril", "initials": "C"}, {"family": "Hamza", "given": "Khadeejah", "initials": "K"}, {"family": "Mohammed", "given": "Tarik Benjamin", "initials": "TB"}, {"family": "Ndodo", "given": "Nnaemeka", "initials": "N"}, {"family": "Obiekea", "given": "Celestina", "initials": "C"}, {"family": "Ofoegbunam", "given": "Chinenye", "initials": "C"}, {"family": "Ogunbode", "given": "Oladipo", "initials": "O"}, {"family": "Ohonsi", "given": "Cornelius", "initials": "C"}, {"family": "Tobin", "given": "Ekaete Alice", "initials": "EA", "orcid": "0000-0001-5059-807X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b9b83f10c75414db97e06c515b1ef8d.json"}}, {"family": "Yashe", "given": "Rimamdeyati", "initials": "R"}, {"family": "Adekaiyaoja", "given": "Afolabi", "initials": "A"}, {"family": "Asuzu", "given": "Michael C", "initials": "MC"}, {"family": "Audu", "given": "Rosemary Ajuma", "initials": "RA"}, {"family": "Bello", "given": "Muhammad Bashir", "initials": "MB"}, {"family": "Bello", "given": "Shaibu Oricha", "initials": "SO"}, {"family": "Deeni", "given": "Yusuf Yahaya", "initials": "YY"}, {"family": "Disu", "given": "Yahya", "initials": "Y"}, {"family": "Joseph", "given": "Gbenga", "initials": "G"}, {"family": "Ezeokafor", "given": "Chidiebere", "initials": "C"}, {"family": "Habib", "given": "Zaiyad Garba", "initials": "ZG"}, {"family": "Ibeh", "given": "Christian", "initials": "C"}, {"family": "Ike", "given": "Ifeanyi Franklin", "initials": "IF"}, {"family": "Iwara", "given": "Emem", "initials": "E"}, {"family": "Luka-Lawal", "given": "Rejoice Kudirat", "initials": "RK"}, {"family": "Namara", "given": "Geoffrey", "initials": "G"}, {"family": "Okwor", "given": "Tochi", "initials": "T"}, {"family": "Olajide", "given": "Lois", "initials": "L"}, {"family": "Ilesanmi", "given": "Oluwafunke Olufemi", "initials": "OO"}, {"family": "Omonigho", "given": "Solomon", "initials": "S"}, {"family": "Oyiri", "given": "Ferdinand", "initials": "F"}, {"family": "Takpa", "given": "Koubagnine", "initials": "K"}, {"family": "Ugbogulu", "given": "Nkem Usha", "initials": "NU"}, {"family": "Ibekwe", "given": "Priscilla", "initials": "P"}, {"family": "Oladejo", "given": "John", "initials": "J"}, {"family": "Ilori", "given": "Elsie", "initials": "E"}, {"family": "Ochu", "given": "Chinwe Lucia", "initials": "CL", "orcid": "0000-0002-0630-7332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f390fa99a654ff899f5e9df6fbaf88e.json"}}, {"family": "Ihekweazu", "given": "Chikwe", "initials": "C"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "11", "issn-l": "2059-7908"}, "abstract": "With reports of surges in COVID-19 case numbers across over 50 countries, country-level epidemiological analysis is required to inform context-appropriate response strategies for containment and mitigation of the outbreak. We aimed to compare the epidemiological features of the first and second waves of COVID-19 in Nigeria.\n\nWe conducted a retrospective analysis of the Surveillance Outbreak Response Management and Analysis System data of the first and second epidemiological waves, which were between 27 February and 24 October 2020, and 25 October 2020 to 3 April 2021, respectively. Descriptive statistical measures including frequencies and percentages, test positivity rate (TPR), cumulative incidence (CI) and case fatality rates (CFRs) were compared. A p value of <0.05 was considered statistically significant. All statistical analyses were carried out in STATA V.13.\n\nThere were 802 143 tests recorded during the study period (362 550 and 439 593 in the first and second waves, respectively). Of these, 66 121 (18.2%) and 91 644 (20.8%) tested positive in the first and second waves, respectively. There was a 21.3% increase in the number of tests conducted in the second wave with TPR increasing by 14.3%. CI during the first and second waves were 30.3/100 000 and 42.0/100 000 respectively. During the second wave, confirmed COVID-19 cases increased among females and people 30 years old or younger and decreased among urban residents and individuals with travel history within 14 days of sample collection (p value <0.001). Most confirmed cases were asymptomatic at diagnosis during both waves: 74.9% in the first wave; 79.7% in the second wave. CFR decreased during the second wave (0.7%) compared with the first wave (1.8%).\n\nNigeria experienced a larger but less severe second wave of COVID-19. Continued implementation of public health and social measures is needed to mitigate the resurgence of another wave.", "doi": "10.1136/bmjgh-2021-007076", "pmid": "34794956", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-007076"}, {"db": "pmc", "key": "PMC8602923"}], "notes": [], "created": "2021-11-26T14:09:34.010Z", "modified": "2021-11-26T14:09:34.139Z"}, {"entity": "publication", "iuid": "31f4a05cc65c4d73a38ca74b9fc9f02f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/31f4a05cc65c4d73a38ca74b9fc9f02f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/31f4a05cc65c4d73a38ca74b9fc9f02f"}}, "title": "Decrease in community antibiotic consumption during the COVID-19 pandemic, EU/EEA, 2020.", "authors": [{"family": "H\u00f6gberg", "given": "Liselotte Diaz", "initials": "LD"}, {"family": "Vlahovi\u0107-Pal\u010devski", "given": "Vera", "initials": "V"}, {"family": "Pereira", "given": "C\u00e1tia", "initials": "C"}, {"family": "Weist", "given": "Klaus", "initials": "K"}, {"family": "Monnet", "given": "Dominique L", "initials": "DL"}, {"family": "ESAC-Net study group", "given": "", "initials": ""}, {"family": "ESAC-Net study group participants", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "46", "issn-l": null}, "abstract": "We present a European Union/European Economic Area-wide overview of the changes in consumption of antibacterials for systemic use (ATC J01) in the community between 2019 and 2020 as reported to the European Surveillance of Antimicrobial Consumption Network. Overall antibiotic consumption decreased by 18.3% between 2019 and 2020, the largest annual decrease in the network's two-decade history. We observed a strong association between the level of community antibiotic consumption in 2019 and the size of the decrease between 2019 and 2020.", "doi": "10.2807/1560-7917.ES.2021.26.46.2101020", "pmid": "34794534", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T14:09:52.886Z", "modified": "2021-11-26T14:09:52.901Z"}, {"entity": "publication", "iuid": "a46b973999d8441ca28db616716d9418", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a46b973999d8441ca28db616716d9418.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a46b973999d8441ca28db616716d9418"}}, "title": "Beyond building back better: imagining a future for human and planetary health.", "authors": [{"family": "de Le\u00f3n", "given": "Emilia Arag\u00f3n", "initials": "EA"}, {"family": "Shriwise", "given": "Amanda", "initials": "A"}, {"family": "Tomson", "given": "G\u00d6ran", "initials": "G"}, {"family": "Morton", "given": "Stephen", "initials": "S"}, {"family": "Lemos", "given": "Diogo Sim\u00e3o", "initials": "DS"}, {"family": "Menne", "given": "Bettina", "initials": "B"}, {"family": "Dooris", "given": "Mark", "initials": "M"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Lancet Planet Health", "issn": "2542-5196", "volume": "5", "issue": "11", "pages": "e827-e839", "issn-l": null}, "abstract": "COVID-19 is disrupting and transforming the world. We argue that transformations catalysed by this pandemic should be used to improve human and planetary health and wellbeing. This paradigm shift requires decision makers and policy makers to go beyond building back better, by nesting the economic domain of sustainable development within social and environmental domains. Drawing on the engage, assess, align, accelerate, and account (E4As) approach to implementing the 2030 Agenda for Sustainable Development, we explore the implications of this kind of radical transformative change, focusing particularly on the role of the health sector. We conclude that a recovery and transition from the COVID-19 pandemic that delivers the future humanity wants and needs requires more than a technical understanding of the transformation at hand. It also requires commitment and courage from leaders and policy makers to challenge dominant constructs and to work towards a truly thriving, equitable, and sustainable future to create a world where economic development is not an end goal itself, but a means to secure the health and wellbeing of people and the planet.", "doi": "10.1016/S2542-5196(21)00262-X", "pmid": "34774123", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2542-5196(21)00262-X"}, {"db": "pmc", "key": "PMC8600369"}], "notes": [], "created": "2021-11-26T14:29:59.933Z", "modified": "2021-11-26T14:50:38.618Z"}, {"entity": "publication", "iuid": "5c9dac66360b4cf9963f4ccc473e1a37", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c9dac66360b4cf9963f4ccc473e1a37.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c9dac66360b4cf9963f4ccc473e1a37"}}, "title": "Allergen Immunotherapy management during vaccinations: An international survey.", "authors": [{"family": "Masieri", "given": "Simonetta", "initials": "S"}, {"family": "Bachert", "given": "Claus", "initials": "C"}, {"family": "Ojeda", "given": "Pedro", "initials": "P"}, {"family": "Kim", "given": "Chang-Keun", "initials": "CK"}, {"family": "Carlo", "given": "Cavaliere", "initials": "C"}, {"family": "Giorgio", "given": "Ciprandi", "initials": "C"}, {"family": "Study Group on AIT & Vaccinations", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "World Allergy Organ J", "issn": "1939-4551", "volume": "14", "issue": "11", "pages": "100601", "issn-l": "1939-4551"}, "abstract": "Vaccination against viral and bacterial pathogens represents a challenging issue in allergic subjects, mainly concerning patients undergoing allergen immunotherapy (AIT). For this reason, an international survey has been performed involving a panel of experts who responded to a series of questions, also concerning the COVID-19 impact on allergen immunotherapy and vaccinations. The results showed that co-administration of vaccines and AIT requires caution, mainly during the pandemic era. Moreover, the choice of AIT product should be oriented considering also the safety profile.", "doi": "10.1016/j.waojou.2021.100601", "pmid": "34777679", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1939-4551(21)00095-8"}, {"db": "pmc", "key": "PMC8575483"}], "notes": [], "created": "2021-11-26T14:25:04.676Z", "modified": "2021-11-26T14:25:04.693Z"}, {"entity": "publication", "iuid": "398f1033a4704b8c8d3fee900804eaba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/398f1033a4704b8c8d3fee900804eaba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/398f1033a4704b8c8d3fee900804eaba"}}, "title": "Flexibility during the COVID-19 Pandemic Response: Healthcare Facility Assessment Tools for Resilient Evaluation.", "authors": [{"family": "Brambilla", "given": "Andrea", "initials": "A", "orcid": "0000-0001-7891-0336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24f99c1c49954fd9a1806ce9641c1dce.json"}}, {"family": "Sun", "given": "Tian-Zhi", "initials": "TZ"}, {"family": "Elshazly", "given": "Waleed", "initials": "W"}, {"family": "Ghazy", "given": "Ahmed", "initials": "A"}, {"family": "Barach", "given": "Paul", "initials": "P"}, {"family": "Lindahl", "given": "G\u00f6ran", "initials": "G"}, {"family": "Capolongo", "given": "Stefano", "initials": "S"}], "type": "journal article", "published": "2021-10-31", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "21", "issn-l": null}, "abstract": "Healthcare facilities are facing huge challenges due to the outbreak of COVID-19. Around the world, national healthcare contingency plans have struggled to cope with the population health impact of COVID-19, with healthcare facilities and critical care systems buckling under the extraordinary pressures. COVID-19 has starkly highlighted the lack of reliable operational tools for assessing the level sof flexibility of a hospital building to support strategic and agile decision making. The aim of this study was to modify, improve and test an existing assessment tool for evaluating hospital facilities flexibility and resilience. We followed a five-step process for collecting data by (i) doing a literature review about flexibility principles and strategies, (ii) reviewing healthcare design guidelines, (iii) examining international healthcare facilities case studies, (iv) conducting a critical review and optimization of the existing tool, and (v) assessing the usability of the evaluation tool. The new version of the OFAT framework (Optimized Flexibility Assessment Tool) is composed of nine evaluation parameters and subdivided into measurable variables with scores ranging from 0 to 10. The pilot testing of case studies enabled the assessment and verification the OFAT validity and reliability in support of decision makers in addressing flexibility of hospital design and/or operations. Healthcare buildings need to be designed and built based on principles of flexibility to accommodate current healthcare operations, adapting to time-sensitive physical transformations and responding to contemporary and future public health emergencies.", "doi": "10.3390/ijerph182111478", "pmid": "34769993", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijerph182111478"}, {"db": "pmc", "key": "PMC8583089"}], "notes": [], "created": "2021-11-26T15:08:47.801Z", "modified": "2021-11-26T15:08:47.858Z"}, {"entity": "publication", "iuid": "9aa3eb392c194c629eb50d77a4876866", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9aa3eb392c194c629eb50d77a4876866.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9aa3eb392c194c629eb50d77a4876866"}}, "title": "Cardiovascular events and safety outcomes associated with remdesivir using a World Health Organization international pharmacovigilance database.", "authors": [{"family": "Jung", "given": "Se Yong", "initials": "SY", "orcid": "0000-0003-1337-563X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e77bcc25ff234e30b8b5b67aab7dc06f.json"}}, {"family": "Kim", "given": "Min Seo", "initials": "MS"}, {"family": "Li", "given": "Han", "initials": "H"}, {"family": "Lee", "given": "Keum Hwa", "initials": "KH", "orcid": "0000-0002-1511-9587", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f05874950d04389af6deb3a0067b914.json"}}, {"family": "Koyanagi", "given": "Ai", "initials": "A", "orcid": "0000-0002-9565-5004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ed135d1694d4ec9858491cfbcba065d.json"}}, {"family": "Solmi", "given": "Marco", "initials": "M"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A", "orcid": "0000-0002-2945-2946", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9e0f16d2f4a444c82a37156bcf3f1b4.json"}}, {"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Tizaoui", "given": "Kalthoum", "initials": "K"}, {"family": "Cargnin", "given": "Sarah", "initials": "S"}, {"family": "Terrazzino", "given": "Salvatore", "initials": "S", "orcid": "0000-0002-4909-1121", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/643fa55ffcdb43fb90bad571f8c0e121.json"}}, {"family": "Hong", "given": "Sung Hwi", "initials": "SH"}, {"family": "Abou Ghayda", "given": "Ramy", "initials": "R"}, {"family": "Kim", "given": "Nam Kyun", "initials": "NK"}, {"family": "Chung", "given": "Seo Kyoung", "initials": "SK"}, {"family": "Jacob", "given": "Louis", "initials": "L", "orcid": "0000-0003-1071-1239", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f59bc7c0941a462aa7426d8e2a995b30.json"}}, {"family": "Salem", "given": "Joe-Elie", "initials": "JE", "orcid": "0000-0002-0331-3307", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48ca28bff1864378845333f93c6926f8.json"}}, {"family": "Yon", "given": "Dong Keon", "initials": "DK", "orcid": "0000-0003-1628-9948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/747eb5856d2e444fbc1e5aaef8d3aa40.json"}}, {"family": "Lee", "given": "Seung Won", "initials": "SW", "orcid": "0000-0001-5632-5208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b38b67e00dbf4d80a72a30152b99c0a3.json"}}, {"family": "Kostev", "given": "Karel", "initials": "K"}, {"family": "Kim", "given": "Ah Young", "initials": "AY"}, {"family": "Jung", "given": "Jo Won", "initials": "JW"}, {"family": "Choi", "given": "Jae Young", "initials": "JY"}, {"family": "Shin", "given": "Jin Soo", "initials": "JS"}, {"family": "Park", "given": "Soon-Jung", "initials": "SJ"}, {"family": "Choi", "given": "Seong Woo", "initials": "SW"}, {"family": "Ban", "given": "Kiwon", "initials": "K"}, {"family": "Moon", "given": "Sung-Hwan", "initials": "SH"}, {"family": "Go", "given": "Yun Young", "initials": "YY"}, {"family": "Shin", "given": "Jae Il", "initials": "JI", "orcid": "0000-0003-2326-1820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ca450cb43e3478d81ba93be745f0ea0.json"}}, {"family": "Smith", "given": "Lee", "initials": "L"}], "type": "journal article", "published": "2021-10-31", "journal": {"title": "Clin Transl Sci", "issn": "1752-8062", "issn-l": "1752-8054"}, "abstract": "On October 2020, the US Food and Drug Administration (FDA) approved remdesivir as the first drug for the treatment of coronavirus disease 2019 (COVID-19), increasing remdesivir prescriptions worldwide. However, potential cardiovascular (CV) toxicities associated with remdesivir remain unknown. We aimed to characterize the CV adverse drug reactions (ADRs) associated with remdesivir using VigiBase, an individual case safety report database of the World Health Organization (WHO). Disproportionality analyses of CV-ADRs associated with remdesivir were performed using reported odds ratios and information components. We conducted in vitro experiments using cardiomyocytes derived from human pluripotent stem cell cardiomyocytes (hPSC-CMs) to confirm cardiotoxicity of remdesivir. To distinguish drug-induced CV-ADRs from COVID-19 effects, we restricted analyses to patients with COVID-19 and found that, after adjusting for multiple confounders, cardiac arrest (adjusted odds ratio [aOR]: 1.88, 95% confidence interval [CI]: 1.08-3.29), bradycardia (aOR: 2.09, 95% CI: 1.24-3.53), and hypotension (aOR: 1.67, 95% CI: 1.03-2.73) were associated with remdesivir. In vitro data demonstrated that remdesivir reduced the cell viability of hPSC-CMs in time- and dose-dependent manners. Physicians should be aware of potential CV consequences following remdesivir use and implement adequate CV monitoring to maintain a tolerable safety margin.", "doi": "10.1111/cts.13168", "pmid": "34719115", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:54:53.842Z", "modified": "2021-11-01T19:54:54.146Z"}, {"entity": "publication", "iuid": "f011d680507b424ca14ca9eda9d3eb7b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f011d680507b424ca14ca9eda9d3eb7b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f011d680507b424ca14ca9eda9d3eb7b"}}, "title": "Stockpiling and food worries: Changing habits and choices in the midst of COVID-19 pandemic.", "authors": [{"family": "Amuakwa-Mensah", "given": "Franklin", "initials": "F"}, {"family": "Amuakwa-Mensah", "given": "Salome", "initials": "S"}, {"family": "Klege", "given": "Rebecca Afua", "initials": "RA"}, {"family": "Adom", "given": "Philip Kofi", "initials": "PK"}], "type": "journal article", "published": "2021-10-30", "journal": {"title": "Socioecon Plann Sci", "issn": "0038-0121", "pages": "101181", "issn-l": null}, "abstract": "Albeit, governments have instituted strong containment measures in the wake of the COVID-19 pandemic, concerns of continuous local spread and economic impact of the virus are impacting global food chains and food security. This paper investigates the effect of concern about the i) local spread and ii) economic impact of COVID-19, on the change in the amount of food and necessities bought in twelve Sub-Sahara African countries. In addition, we examine if these effects are channeled through food worries. The study uses a unique survey dataset by GeoPoll collected in April 2020 (first round) and May 2020 (second round) and employs a multinomial logit and generalized structural equation models. We find significant effect of concern about COVID-19 on change in the package size of food and necessities bought, which is heterogeneous across gender group and rural-urban divide. Our results reveal that concerns of COVID-19 might be promoting stockpiling behavior among females and those with no food worries (due to having sufficient money or resources). This if not properly managed could in the medium to long-term affect the food supply chain, food waste and exacerbate food worries problem especially for already food deprived homes. We discuss the policy implications.", "doi": "10.1016/j.seps.2021.101181", "pmid": "34744190", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0038-0121(21)00173-7"}, {"db": "pmc", "key": "PMC8562977"}], "notes": [], "created": "2021-11-26T15:36:31.982Z", "modified": "2021-11-26T15:36:32.016Z"}, {"entity": "publication", "iuid": "f6aa34deb2484c9cab3553f51015f89d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6aa34deb2484c9cab3553f51015f89d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6aa34deb2484c9cab3553f51015f89d"}}, "title": "Quality of Life, Needs and Fears of Mothers of Children with Disabilities in Saudi Arabia during the COVID-19 Lockdown.", "authors": [{"family": "Al Awaji", "given": "Nisreen", "initials": "N"}, {"family": "Aldhahi", "given": "Monira", "initials": "M", "orcid": "0000-0002-5255-4860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a3b7b4eb7d6440da62df1e4d091329b.json"}}, {"family": "Akil", "given": "Shahnaz", "initials": "S", "orcid": "0000-0002-3256-4543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c031d893b12b4c4ca8cbb330a89384d0.json"}}, {"family": "Awad", "given": "Salwa", "initials": "S"}, {"family": "Mortada", "given": "Eman", "initials": "E"}], "type": "journal article", "published": "2021-10-30", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "21", "pages": null}, "abstract": "Substantial changes in life dynamics resulting from the outbreak of the coronavirus disease 2019 (COVID-19) could have an impact on the quality of life (QoL) of mothers of children with and without disabilities. This study compared the quality of life (QoL) of mothers of children with disabilities (MCD) to the QoL of mothers of children without disabilities (CON) in Saudi Arabia during COVID-19 lockdown. It explored mothers' concerns and the type of support they need during the quarantine. A comparative cross-sectional study was conducted during the lockdown. An online questionnaire was distributed to mothers raising children with and without disabilities in Saudi Arabia. A total of 340 mothers participated in the study by completing the survey: 93 MCD and 247 CON. The QoL of MCD and CON was assessed using the WHOQOL-BREF questionnaire. Furthermore, detailed information was provided by the mothers regarding their needs and concerns during the lockdown. The results of the study revealed that the overall QoL was significantly higher in the CON group, compared to the MCD group, during the COVID-19 lockdown. The social well-being and environmental well-being reported by MCD were significantly lower on the total scale of the WHOQOL-BREF than those reported by the CON group. The comparison between the two groups revealed significant differences in the support required by mothers during the COVID-19 pandemic: a higher percentage of MCD needed emotional and psychological support, especially from family members. The major concerns reported by MCD were the deterioration of their children's medical conditions and the lack of medical supplies during the lockdown.", "doi": "10.3390/ijerph182111442", "pmid": "34769958", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182111442"}, {"db": "pmc", "key": "PMC8583177"}], "notes": [], "created": "2021-11-26T15:09:15.845Z", "modified": "2022-02-17T12:28:28.363Z"}, {"entity": "publication", "iuid": "6c6a0d8aa3044e1d85c5d613e6374d85", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c6a0d8aa3044e1d85c5d613e6374d85.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c6a0d8aa3044e1d85c5d613e6374d85"}}, "title": "On the brink of disruption: Applying Resilience Engineering to anticipate system performance under crisis.", "authors": [{"family": "Arcuri", "given": "Rodrigo", "initials": "R"}, {"family": "Bellas", "given": "Hugo Cesar", "initials": "HC"}, {"family": "Ferreira", "given": "Denise de Souza", "initials": "DS"}, {"family": "Bulh\u00f5es", "given": "B\u00e1rbara", "initials": "B"}, {"family": "Vidal", "given": "Mario Cesar Rodr\u00edguez", "initials": "MCR"}, {"family": "Carvalho", "given": "Paulo Victor Rodrigues de", "initials": "PVR"}, {"family": "Jatob\u00e1", "given": "Alessandro", "initials": "A"}, {"family": "Hollnagel", "given": "Erik", "initials": "E"}], "type": "journal article", "published": "2021-10-30", "journal": {"title": "Appl Ergon", "issn": "1872-9126", "volume": "99", "pages": "103632", "issn-l": null}, "abstract": "As COVID-19 spread across Brazil, it quickly reached remote regions including Amazon's ultra-peripheral locations where patient transportation through rivers is added to the list of obstacles to overcome. This article analyses the pandemic's effects in the access of riverine communities to the prehospital emergency healthcare system in the Brazilian Upper Amazon River region. To do so, we present two studies that by using a Resilience Engineering approach aimed to predict the functioning of the Brazilian Mobile Emergency Medical Service (SAMU) for riverside and coastal areas during the COVID-19 pandemic, based on the normal system functioning. Study I, carried out before the pandemic, applied ethnographic methods for data collection and the Functional Resonance Analysis Method - FRAM for data analysis in order to develop a model of the mobile emergency care in the region during typical conditions of operation. Study II then estimated how changes in variability dynamics would alter system functioning during the pandemic, arriving at three trends that could lead the service to collapse. Finally, the accuracy of predictions is discussed after the pandemic first peaked in the region. Findings reveal that relatively small changes in variability dynamics can deliver strong implications to operating care and safety of expeditions aboard water ambulances. Also, important elements that add to the resilient capabilities of the system are extra-organizational, and thus during the pandemic safety became jeopardized as informal support networks grew fragile. Using FRAM for modelling regular operation enabled prospective scenario analysis that accurately predicted disruptions in providing emergency care to riverine population.", "doi": "10.1016/j.apergo.2021.103632", "pmid": "34740073", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0003-6870(21)00279-9"}, {"db": "pmc", "key": "PMC8557093"}], "notes": [], "created": "2021-11-08T09:20:43.862Z", "modified": "2021-11-08T09:20:43.899Z"}, {"entity": "publication", "iuid": "ac08bcfa36fc43cdab597875f30bf61d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac08bcfa36fc43cdab597875f30bf61d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac08bcfa36fc43cdab597875f30bf61d"}}, "title": "Circulating levels of calprotectin, a signature of neutrophil activation in prediction of severe respiratory failure in COVID-19 patients: a multicenter, prospective study (CalCov study).", "authors": [{"family": "Garc\u00eda de Guadiana-Romualdo", "given": "Luis", "initials": "L", "orcid": "0000-0003-3028-3198", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2733220d3ab54ff5adb9fe765ee033a8.json"}}, {"family": "Rodr\u00edguez Rojas", "given": "Carlos", "initials": "C"}, {"family": "Morell-Garc\u00eda", "given": "Daniel", "initials": "D"}, {"family": "Andaluz-Ojeda", "given": "David", "initials": "D"}, {"family": "Rodr\u00edguez Mulero", "given": "Mar\u00eda Dolores", "initials": "MD"}, {"family": "Rodr\u00edguez-Borja", "given": "Enrique", "initials": "E"}, {"family": "Ballesteros-Vizoso", "given": "Antonieta", "initials": "A"}, {"family": "Calvo", "given": "Mar\u00eda Dolores", "initials": "MD"}, {"family": "Albert-Botella", "given": "Lourdes", "initials": "L"}, {"family": "Pozo Gir\u00e1ldez", "given": "Adela", "initials": "A"}, {"family": "Llompart-Alabern", "given": "Isabel", "initials": "I"}, {"family": "Bolado Jim\u00e9nez", "given": "Cristina", "initials": "C"}, {"family": "Hern\u00e1ndez Olivo", "given": "Marta", "initials": "M"}, {"family": "Fern\u00e1ndez Presa", "given": "Luc\u00eda", "initials": "L"}, {"family": "Ortega-P\u00e9rez", "given": "Juan", "initials": "J"}, {"family": "Fora Romero", "given": "Mar\u00eda Jos\u00e9", "initials": "MJ"}, {"family": "Campos-Rodr\u00edguez", "given": "Valerio", "initials": "V"}, {"family": "Ballester F\u00e9rriz", "given": "Andrea", "initials": "A"}, {"family": "Guiu-Mart\u00ed", "given": "Alexandra M", "initials": "AM"}, {"family": "Pinilla Arribas", "given": "Leyre", "initials": "L"}, {"family": "Galindo Mart\u00ednez", "given": "Mar\u00eda", "initials": "M"}, {"family": "Puerto-Lara", "given": "Edwin R", "initials": "ER"}, {"family": "L\u00f3pez Tarazaga", "given": "Ana Belen", "initials": "AB"}, {"family": "Ros Braquehais", "given": "Mar\u00eda Salom\u00e9", "initials": "MS"}, {"family": "Nogales Mart\u00edn", "given": "Leonor", "initials": "L"}, {"family": "Juez Santamar\u00eda", "given": "Celia", "initials": "C"}, {"family": "Trapiello Fern\u00e1ndez", "given": "Wysalli", "initials": "W"}, {"family": "Espinilla Fern\u00e1ndez", "given": "Virginia", "initials": "V"}, {"family": "Havelka", "given": "Aleksandra", "initials": "A"}, {"family": "Albaladejo-Ot\u00f3n", "given": "Mar\u00eda Dolores", "initials": "MD"}], "type": "journal article", "published": "2021-10-30", "journal": {"title": "Inflamm Res", "issn": "1420-908X", "issn-l": null}, "abstract": "Severe COVID-19 is characterized by a dysregulated immune response in which neutrophils play a critical role. Calprotectin reflects neutrophil activation and is involved in the self-amplifying thrombo-inflammatory storm in severe COVID-19. We aimed to evaluate the role of calprotectin in early prediction of severity in COVID-19 patients.\n\nThis was a multicenter prospective observational study enrolling consecutive adult COVID-19 patients. On arrival to emergency department, blood samples were collected for laboratory tests, including serum calprotectin. The primary outcome was severe respiratory failure requiring invasive mechanical ventilation and the secondary outcome was need for Intensive Care Unit (ICU) admission.\n\nStudy population included 395 patients, 57 (14.4%) required invasive mechanical ventilation and 100 (25.3%) were admitted to ICU. Median serum calprotectin levels were significantly higher in intubated (3.73 mg/L vs. 2.63 mg/L; p < 0.001) and ICU patients (3.48 mg/L vs. 2.60 mg/L; p = 0.001). Calprotectin showed a significant accuracy to predict the need for invasive mechanical ventilation (ROC AUC 0.723) and ICU admission (ROC AUC 0.650). In multivariate analysis, serum calprotectin was an independent predictor of invasive mechanical ventilation (OR 1.161) and ICU admission (OR 1.068).\n\nSerum calprotectin can be used as an early predictor of severity in COVID-19 patients.", "doi": "10.1007/s00011-021-01516-4", "pmid": "34718856", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00011-021-01516-4"}], "notes": [], "created": "2021-11-01T19:54:06.861Z", "modified": "2021-11-01T19:54:21.246Z"}, {"entity": "publication", "iuid": "df253a1d3287495c9060e507e78366d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/df253a1d3287495c9060e507e78366d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/df253a1d3287495c9060e507e78366d9"}}, "title": "The mediational role of trust in the healthcare system in the association between generalized trust and willingness to get COVID-19 vaccination in Iran.", "authors": [{"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Yahaghai", "given": "Rafat", "initials": "R"}, {"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-10-29", "journal": {"title": "Hum Vaccin Immunother", "issn": "2164-554X", "pages": "1-8", "issn-l": null}, "abstract": "For some individuals, there appears to be some level of unwillingness in getting a COVID-19 vaccine which may be due to trust issues. The present study used a mediation model to investigate how trust is associated with an individual's willingness to get COVID-19 vaccination among Iranians. A total of 10,843 Iranian adults were recruited in Qazvin province using a multistage stratified cluster sampling method. The survey was completed between February 19 and April 9, 2021. The findings showed that generalized trust was positively associated with trust in the healthcare system, trust in the healthcare system was positively associated with willingness to get COVID-19 vaccination, and generalized trust was positively associated with willingness to get COVID-19 vaccination. Also, trust in the healthcare system mediated the association between generalized trust and willingness to get COVID-19 vaccination. There were some significant demographic differences in COVID-19 vaccination willingness. The findings suggest that generalized trust plays a significant role in directly or indirectly influencing individuals' willingness to get COVID-19 vaccine. Therefore, government bodies and health officials may utilize these findings to appeal in a more transparent and professional manner in encouraging individuals to get a COVID-19 vaccine. However, for those with lower trust levels (in general and in the healthcare system), the focus may be to re-build and/or regain the individuals' trust through carefully planned transparent communication, information dissemination, and ethical education to help increase the uptake of COVID-19 vaccination.", "doi": "10.1080/21645515.2021.1993689", "pmid": "34715009", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:52:03.368Z", "modified": "2021-11-01T19:52:19.468Z"}, {"entity": "publication", "iuid": "629a71d80887407eb7e5a456db40bb93", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/629a71d80887407eb7e5a456db40bb93.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/629a71d80887407eb7e5a456db40bb93"}}, "title": "Patient delay prior to care-seeking in acute myocardial infarction during the outbreak of the coronavirus SARS-CoV2 pandemic.", "authors": [{"family": "Lidin", "given": "Matthias", "initials": "M"}, {"family": "Lyng\u00e5", "given": "Patrik", "initials": "P"}, {"family": "Kinch-Westerdahl", "given": "Annika", "initials": "A"}, {"family": "Nymark", "given": "Carolin", "initials": "C", "orcid": "0000-0003-0891-6358", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26ae7dfc5d824e6ba7fda3c21ac670ef.json"}}], "type": "journal article", "published": "2021-10-29", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "issn-l": null}, "abstract": "To examine patient delay in seeking medical care when afflicted by an acute myocardial infarction during March-June 2020.\n\nThis was a cross-sectional study in a region in Sweden during the first wave of the COVID-19 pandemic examining patients selected from the national registry (SWEDEHEART). Eligible patients were those with acute myocardial infarction, and a total of 602 patients were invited. A self-administered psychometric evaluated questionnaire, 'Patients' appraisal, emotions, and action tendencies preceding care-seeking in acute myocardial infarction' (AMI), was sent to the patients, and questions regarding COVID-19 were added. A total of 326 patients answered the questionnaire. Of these, 19% hesitated to seek medical care because of the pandemic, which was related to a fear that the healthcare services were already overcrowded with patients with COVID-19, followed by a fear of becoming infected with COVID-19 in hospital. Characteristics of this cohort were significantly higher prevalences of women, immigrants, smokers, and patients with type 2 diabetes.\n\nDuring the outbreak and first wave of the COVID-19 pandemic, women and immigrants delayed seeking medical care for AMI because of fears about overcrowded hospitals and about becoming infected themselves. Therefore, during the COVID-19 pandemic, it is especially important to convey information about how and when to seek medical care. A collaboration involving the healthcare professionals, patient organizations, and the media would be desirable.", "doi": "10.1093/eurjcn/zvab087", "pmid": "34718511", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6414289"}], "notes": [], "created": "2021-11-01T19:53:39.156Z", "modified": "2021-11-01T19:53:39.196Z"}, {"entity": "publication", "iuid": "f7807f3a744240b5aa8bc1c5aad426d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7807f3a744240b5aa8bc1c5aad426d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7807f3a744240b5aa8bc1c5aad426d4"}}, "title": "Effect of Resilience on Health-Related Quality of Life during the COVID-19 Pandemic: A Cross-Sectional Study.", "authors": [{"family": "Aldhahi", "given": "Monira I", "initials": "MI", "orcid": "0000-0002-5255-4860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a3b7b4eb7d6440da62df1e4d091329b.json"}}, {"family": "Akil", "given": "Shahnaz", "initials": "S", "orcid": "0000-0002-3256-4543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c031d893b12b4c4ca8cbb330a89384d0.json"}}, {"family": "Zaidi", "given": "Uzma", "initials": "U"}, {"family": "Mortada", "given": "Eman", "initials": "E"}, {"family": "Awad", "given": "Salwa", "initials": "S"}, {"family": "Al Awaji", "given": "Nisreen", "initials": "N", "orcid": "0000-0002-1853-0398", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ea5b5f49bdb409fada8f8aab77ae39b.json"}}], "type": "journal article", "published": "2021-10-29", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "21", "pages": null}, "abstract": "The unprecedented outbreak of coronavirus disease 2019 (COVID-19) has caused a huge global health and economic crisis. The aim of the study was to examine the extent to which the resilience of a person is associated with the quality of life (QoL) of adults amongst Saudi Arabia. A cross-sectional study was conducted among a sample of adults in Saudi Arabia. A total of 385 adults voluntarily participated in and completed the survey. The quality of life was measured using the \"World Health Organization QoL\". The \"Connor-Davidson Resilience Scale\" instrument was also used to assess resilience during the COVID-19 pandemic. Amongst the 385 participants, 179 (46%) showed a good QoL, and 205 (54%) reported a relatively poor QoL. The resilience was found to be significantly associated with QoL. The study further revealed that gender-based differences were dominant in the QoL; the men respondents reported a significantly higher QoL in all the domains in comparison to the women respondents. The gender, income, and psychological health and interaction effect of resilience and age explained 40% of the variance in the total score of QoL. In reference to the predictors of the physical health domain of QoL, resilience, gender, and psychological health were significantly associated with the physical health domain of the QoL (R2 = 0.26, p = 0.001). It was also noted that gender was not associated with the social relationships and environmental domains of QoL (p > 0.05). Findings showed a statistically significant association between the score of QoL and resilience, age, gender, income, and psychological health. These findings highlight the significant contribution of gender-based differences, psychological health, and resilience on the domains of QoL.", "doi": "10.3390/ijerph182111394", "pmid": "34769907", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182111394"}, {"db": "pmc", "key": "PMC8582796"}], "notes": [], "created": "2021-11-26T15:09:47.678Z", "modified": "2022-02-17T12:26:29.079Z"}, {"entity": "publication", "iuid": "6b1c03b1fc744ce7bd7498966d975600", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b1c03b1fc744ce7bd7498966d975600.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b1c03b1fc744ce7bd7498966d975600"}}, "title": "Detection of SARS-CoV-2 by rapid antigen tests on saliva in hospitalized patients with COVID-19.", "authors": [{"family": "De Marinis", "given": "Yang", "initials": "Y", "orcid": "0000-0002-8081-2142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c85c6f6e14a44415a2bea1cfe224e50c.json"}}, {"family": "Pesola", "given": "Anne-Katrine", "initials": "AK"}, {"family": "S\u00f6derlund Strand", "given": "Anna", "initials": "A"}, {"family": "Norman", "given": "Astrid", "initials": "A"}, {"family": "Pernow", "given": "Gustav", "initials": "G"}, {"family": "Ald\u00e9n", "given": "Markus", "initials": "M"}, {"family": "Yang", "given": "Runtao", "initials": "R"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1588-5473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c760e8d21ae441ba236f86e6185d392.json"}}], "type": "journal article", "published": "2021-10-29", "journal": {"title": "Infect Ecol Epidemiol", "issn": "2000-8686", "volume": "11", "issue": "1", "pages": "1993535", "issn-l": "2000-8686"}, "abstract": "The COVID-19 pandemic presents great challenges on transmission prevention, and rapid diagnosis is essential to reduce the disease spread. Various diagnostic methods are available to identify an ongoing infection by nasopharyngeal (NPH) swab sampling. However, the procedure requires handling by health care professionals, and therefore limits the application in household and community settings.\n\nIn this study, we aimed to determine if the detection of SARS-CoV-2 can be performed alternatively on saliva specimens by rapid antigen test.\n\nSaliva and NPH specimens were collected from 44 patients with confirmed COVID-19. To assess the diagnostic accuracy of point-of-care SARS-CoV-2 rapid antigen test on saliva specimens, we compared the performance of four test products.\n\nRT-qPCR was performed and NPH and saliva sampling had similar Ct values, which associated with disease duration. All four antigen tests showed similar trend in detecting SARS-CoV-2 in saliva, but with variation in the ability to detect positive cases. The rapid antigen test with the best performance could detect up to 67% of the positive cases with Ct values lower than 25, and disease duration shorter than 10 days.\n\nOur study therefore supports saliva testing as an alternative diagnostic procedure to NPH testing, and that rapid antigen test on saliva provides a potential complement to PCR test to meet increasing screening demand.", "doi": "10.1080/20008686.2021.1993535", "pmid": "34745449", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "1993535"}, {"db": "pmc", "key": "PMC8567870"}], "notes": [], "created": "2021-11-10T11:40:29.186Z", "modified": "2021-11-26T15:35:05.776Z"}, {"entity": "publication", "iuid": "62ff8b720a574f95a3e5c8707da35fd6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/62ff8b720a574f95a3e5c8707da35fd6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/62ff8b720a574f95a3e5c8707da35fd6"}}, "title": "The Barriers, Challenges, and Strategies of COVID-19 (SARS-CoV-2) Vaccine Acceptance: A Concurrent Mixed-Method Study in Tehran City, Iran.", "authors": [{"family": "Khankeh", "given": "Hamid Reza", "initials": "HR"}, {"family": "Farrokhi", "given": "Mehrdad", "initials": "M"}, {"family": "Khanjani", "given": "Mohammad Saeed", "initials": "MS"}, {"family": "Momtaz", "given": "Yadollah Abolfathi", "initials": "YA", "orcid": "0000-0003-1939-1470", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d0e1d04e09d74c19b349fac72d8e6cd7.json"}}, {"family": "Forouzan", "given": "Ameneh Setareh", "initials": "AS", "orcid": "0000-0001-9668-1389", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80e56b61b3a0447ebd9865c0f1a734a7.json"}}, {"family": "Norouzi", "given": "Mehdi", "initials": "M"}, {"family": "Ahmadi", "given": "Shokoufeh", "initials": "S"}, {"family": "Harouni", "given": "Gholamreza Ghaedamini", "initials": "GG", "orcid": "0000-0003-1197-5068", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09e64a733cff438ea73ced998027307d.json"}}, {"family": "Roudini", "given": "Juliet", "initials": "J"}, {"family": "Ghanaatpisheh", "given": "Elham", "initials": "E"}, {"family": "Hamedanchi", "given": "Arya", "initials": "A", "orcid": "0000-0001-5879-5561", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69adb9f4402744879df4d532e6d609a8.json"}}, {"family": "Pourebrahimi", "given": "Mohammad", "initials": "M"}, {"family": "Alipour", "given": "Fardin", "initials": "F"}, {"family": "Ranjbar", "given": "Maryam", "initials": "M"}, {"family": "Naghikhani", "given": "Mehrdad", "initials": "M"}, {"family": "Saatchi", "given": "Mohammad", "initials": "M"}], "type": "journal article", "published": "2021-10-28", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "9", "issue": "11", "issn-l": null}, "abstract": "Acceptance and willingness to receive the vaccine are among the main factors in the success or failure of a health system in implementing the vaccination program. The present study was conducted in Tehran, the political and economic capital of Iran, to determine the acceptance of the COVID-19 vaccine and identify its associated factors, and explain the most important barriers and acceptance strategies for vaccination. This research was a concurrent quantitative and qualitative mixed-method study. In the quantitative part, 1200 individuals aged more than 18 years were selected from the households in 22 districts of Tehran City, with a multistage stratified cluster sampling method. Two questionnaires were used to evaluate the acceptance of the COVID-19 vaccine and vaccine acceptance determinants. The qualitative content analysis method addressed the influencing factors, as well as challenges and strategies related to the acceptance of the COVID-19 vaccine in four groups of Tehran inhabitants: the elderly, people with underlying diseases, healthcare workers, and the general population. The related data were simultaneously collected by applying in-depth semi-structural interviews and a data analysis process. Furthermore, we used the Graneheim and Lundman method for data analysis. We analyzed the data of 1200 people with a mean (SD) age of 46.4 (11.1) years, and approximately 58% of them were men. The vaccine acceptance was 83.6% (95% CI: 81.3-85.9). Among those who welcomed vaccination, 58% preferred the imported vaccines, 25% the Iranian ones, and 17% both. There was a significant association between the variables of age (adjusted odds ratio [AOR] = 1.72, 95% CI: 1.01-2.93), being single (AOR = 0.54, 95% CI: 0.41-0.91), moderate pharmacotherapy adherence (AOR = 0.58, 95% CI: 0.4-0.85), and the willingness to receive COVID-19 vaccine. Qualitative study after interviewing 45 people from four study groups showed an insufficient social trust in healthcare system officials, pharmaceutical and vaccine production companies; distrust in the effectiveness of the vaccines, concerns about the vaccine adverse effects, being tracked by microchips after vaccination, traditional anti-vaccination movements, the feeling the inessentiality of vaccination, and uncertainty about the fair distribution of the vaccine. These concerns were the main challenges addressed by the study groups. A good proportion of Tehran residents reported their willingness to receive the COVID-19 vaccine. Additionally, they expressed their critical concerns, such as insufficient trust in the healthcare system, vaccine safeties, and adverse effects that were the significant barriers to vaccine acceptance. It seems that conflicts raised by the shortage of vaccines and their import due to the sanctions have led to intense desire and demand in the general population, and especially the elderly, for vaccination. Besides, vaccination phobia in some individuals requires further investigations.", "doi": "10.3390/vaccines9111248", "pmid": "34835179", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "vaccines9111248"}, {"db": "pmc", "key": "PMC8620861"}], "notes": [], "created": "2021-12-18T18:14:17.824Z", "modified": "2021-12-18T18:14:30.396Z"}, {"entity": "publication", "iuid": "16b970005ba045cfb91c5d275a6062f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16b970005ba045cfb91c5d275a6062f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16b970005ba045cfb91c5d275a6062f1"}}, "title": "Rapid inactivation of SARS-CoV-2 with LED irradiation of visible spectrum wavelengths.", "authors": [{"family": "De Santis", "given": "Riccardo", "initials": "R"}, {"family": "Luca", "given": "Vincenzo", "initials": "V"}, {"family": "N\u00e4slund", "given": "Jonas", "initials": "J"}, {"family": "Ehmann", "given": "Rosina K", "initials": "RK"}, {"family": "De Angelis", "given": "Marta", "initials": "M"}, {"family": "Lundmark", "given": "Eva", "initials": "E"}, {"family": "Nencioni", "given": "Lucia", "initials": "L"}, {"family": "Faggioni", "given": "Giovanni", "initials": "G"}, {"family": "Fillo", "given": "Silvia", "initials": "S"}, {"family": "Amatore", "given": "Donatella", "initials": "D"}, {"family": "Regalbuto", "given": "Elisa", "initials": "E"}, {"family": "Molinari", "given": "Filippo", "initials": "F"}, {"family": "Petralito", "given": "Giancarlo", "initials": "G"}, {"family": "W\u00f6lfel", "given": "Roman", "initials": "R"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Rezza", "given": "Gianni", "initials": "G"}, {"family": "Palamara", "given": "Anna Teresa", "initials": "AT"}, {"family": "Antwerpen", "given": "Markus", "initials": "M"}, {"family": "Forsman", "given": "Mats", "initials": "M"}, {"family": "Lista", "given": "Florigio", "initials": "F"}], "type": "journal article", "published": "2021-10-28", "journal": {"title": "J Photochem Photobiol", "issn": "2666-4690", "pages": "100082", "issn-l": null}, "abstract": "Difficulty in controlling SARS-CoV-2 transmission made the ability to inactivate viruses in aerosols and fomites to be an important and attractive risk reduction measure. Evidence that light frequencies have the ability to inhibit microorganisms has already been reported by many studies which, however, focused on ultraviolet (UV) wavelengths, which are known to induce potential injury in humans. In the present study, the effect on suspensions of SARS-CoV-2 of a Light Emitting Diode (LED) device capable of radiating frequencies in the non-hazardous visible light spectrum (VIS) was investigated. In order to evaluate the efficiency of viral inactivation, plaque assay and western blot of viral proteins were performed. The observed results showed a significant reduction in infectious particles that had been exposed to the LED irradiation of visible light. Furthermore, the analysis of the intracellular expression of viral proteins confirmed the inactivating effect of this irradiation technology. This in vitro study revealed for the first time the inactivation of SAR-CoV-2 through LED irradiation with multiple wavelengths of the visible spectrum. However additional and more in-depth studies can aim to demonstrate the data obtained during these experiments in different matrices, in mutable environmental conditions and on other respiratory viruses such as the influenza virus, the type of LED technology can decisively contribute on reducing virus transmission through the continuous sanitation of common environments without risks for humans and animals.", "doi": "10.1016/j.jpap.2021.100082", "pmid": "34729540", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2666-4690(21)00067-1"}, {"db": "pmc", "key": "PMC8552801"}], "notes": [], "created": "2021-11-08T09:06:28.550Z", "modified": "2021-11-08T09:06:28.588Z"}, {"entity": "publication", "iuid": "66a83c2299dc46f2b4ae52efcb0ca12a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66a83c2299dc46f2b4ae52efcb0ca12a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66a83c2299dc46f2b4ae52efcb0ca12a"}}, "title": "Health, Lifestyle, and Psycho-Social Determinants of Poor Sleep Quality During the Early Phase of the COVID-19 Pandemic: A Focus on UK Older Adults Deemed Clinically Extremely Vulnerable.", "authors": [{"family": "Udeh-Momoh", "given": "Chinedu T", "initials": "CT"}, {"family": "Watermeyer", "given": "Tamlyn", "initials": "T"}, {"family": "Sindi", "given": "Shireen", "initials": "S"}, {"family": "Giannakopoulou", "given": "Parthenia", "initials": "P"}, {"family": "Robb", "given": "Catherine E", "initials": "CE"}, {"family": "Ahmadi-Abhari", "given": "Sara", "initials": "S"}, {"family": "Zheng", "given": "Bang", "initials": "B"}, {"family": "Waheed", "given": "Amina", "initials": "A"}, {"family": "McKeand", "given": "James", "initials": "J"}, {"family": "Salman", "given": "David", "initials": "D"}, {"family": "Beaney", "given": "Thomas", "initials": "T"}, {"family": "de Jager Loots", "given": "Celeste A", "initials": "CA"}, {"family": "Price", "given": "Geraint", "initials": "G"}, {"family": "Atchison", "given": "Christina", "initials": "C"}, {"family": "Car", "given": "Josip", "initials": "J"}, {"family": "Majeed", "given": "Azeem", "initials": "A"}, {"family": "McGregor", "given": "Alison H", "initials": "AH"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Ward", "given": "Helen", "initials": "H"}, {"family": "Middleton", "given": "Lefkos T", "initials": "LT"}], "type": "journal article", "published": "2021-10-28", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "753964", "issn-l": "2296-2565"}, "abstract": "Background: Several studies have assessed the impact of COVID-19-related lockdowns on sleep quality across global populations. However, no study to date has specifically assessed at-risk populations, particularly those at highest risk of complications from coronavirus infection deemed \"clinically-extremely-vulnerable-(COVID-19CEV)\" (as defined by Public Health England). Methods: In this cross-sectional study, we surveyed 5,558 adults aged \u226550 years (of whom 523 met criteria for COVID-19CEV) during the first pandemic wave that resulted in a nationwide-lockdown (April-June 2020) with assessments of sleep quality (an adapted sleep scale that captured multiple sleep indices before and during the lockdown), health/medical, lifestyle, psychosocial and socio-demographic factors. We examined associations between these variables and sleep quality; and explored interactions of COVID-19CEV status with significant predictors of poor sleep, to identify potential moderating factors. Results: Thirty-seven percent of participants reported poor sleep quality which was associated with younger age, female sex and multimorbidity. Significant associations with poor sleep included health/medical factors: COVID-19CEV status, higher BMI, arthritis, pulmonary disease, and mental health disorders; and the following lifestyle and psychosocial factors: living alone, higher alcohol consumption, an unhealthy diet and higher depressive and anxiety symptoms. Moderators of the negative relationship between COVID-19CEV status and good sleep quality were marital status, loneliness, anxiety and diet. Within this subgroup, less anxious and less lonely males, as well as females with healthier diets, reported better sleep. Conclusions: Sleep quality in older adults was compromised during the sudden unprecedented nation-wide lockdown due to distinct modifiable factors. An important contribution of our study is the assessment of a \"clinically-extremely-vulnerable\" population and the sex differences identified within this group. Male and female older adults deemed COVID-19CEV may benefit from targeted mental health and dietary interventions, respectively. This work extends the available evidence on the notable impact of lack of social interactions during the COVID-19 pandemic on sleep, and provides recommendations toward areas for future work, including research into vulnerability factors impacting sleep disruption and COVID-19-related complications. Study results may inform tailored interventions targeted at modifiable risk factors to promote optimal sleep; additionally, providing empirical data to support health policy development in this area.", "doi": "10.3389/fpubh.2021.753964", "pmid": "34869170", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8637825"}], "notes": [], "created": "2021-12-12T07:09:20.670Z", "modified": "2021-12-12T07:09:20.684Z"}, {"entity": "publication", "iuid": "3217be6cf6ad4eaeaffbf01370c6b69d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3217be6cf6ad4eaeaffbf01370c6b69d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3217be6cf6ad4eaeaffbf01370c6b69d"}}, "title": "Comparative safety of mRNA COVID-19 vaccines to influenza vaccines: A pharmacovigilance analysis using WHO international database.", "authors": [{"family": "Kim", "given": "Min Seo", "initials": "MS", "orcid": "0000-0003-2115-7835", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3078a38bd45044b3ac5b32d0eb09fbda.json"}}, {"family": "Jung", "given": "Se Yong", "initials": "SY", "orcid": "0000-0003-1337-563X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e77bcc25ff234e30b8b5b67aab7dc06f.json"}}, {"family": "Ahn", "given": "Jong Gyun", "initials": "JG"}, {"family": "Park", "given": "Se Jin", "initials": "SJ"}, {"family": "Shoenfeld", "given": "Yehuda", "initials": "Y"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Tizaoui", "given": "Kalthoum", "initials": "K", "orcid": "0000-0001-8524-6058", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/acc834b554f14509911d1a594332a808.json"}}, {"family": "Hong", "given": "Sung Hwi", "initials": "SH"}, {"family": "Jacob", "given": "Louis", "initials": "L", "orcid": "0000-0003-1071-1239", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f59bc7c0941a462aa7426d8e2a995b30.json"}}, {"family": "Salem", "given": "Joe-Elie", "initials": "JE"}, {"family": "Yon", "given": "Dong Keon", "initials": "DK", "orcid": "0000-0003-1628-9948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/747eb5856d2e444fbc1e5aaef8d3aa40.json"}}, {"family": "Lee", "given": "Seung Won", "initials": "SW", "orcid": "0000-0001-5632-5208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b38b67e00dbf4d80a72a30152b99c0a3.json"}}, {"family": "Ogino", "given": "Shuji", "initials": "S", "orcid": "0000-0002-3909-2323", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/310326a713e7419ba514ded7472e97b6.json"}}, {"family": "Kim", "given": "Hanna", "initials": "H"}, {"family": "Kim", "given": "Jerome H", "initials": "JH"}, {"family": "Excler", "given": "Jean-Louis", "initials": "JL"}, {"family": "Marks", "given": "Florian", "initials": "F"}, {"family": "Clemens", "given": "John D", "initials": "JD"}, {"family": "Eisenhut", "given": "Michael", "initials": "M"}, {"family": "Barnett", "given": "Yvonne", "initials": "Y"}, {"family": "Butler", "given": "Laurie", "initials": "L"}, {"family": "Ilie", "given": "Cristian Petre", "initials": "CP"}, {"family": "Shin", "given": "Eui-Cheol", "initials": "EC", "orcid": "0000-0002-6308-9503", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbc368fed9a340a1adcd420100422844.json"}}, {"family": "Il Shin", "given": "Jae", "initials": "J", "orcid": "0000-0003-2326-1820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ca450cb43e3478d81ba93be745f0ea0.json"}}, {"family": "Smith", "given": "Lee", "initials": "L"}], "type": "journal article", "published": "2021-10-28", "journal": {"title": "J Med Virol", "issn": "1096-9071", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Two messenger RNA (mRNA) vaccines developed by Pfizer-BioNTech and Moderna are being rolled out. Despite the high volume of emerging evidence regarding adverse events (AEs) associated with the COVID-19 mRNA vaccines, previous studies have thus far been largely based on the comparison between vaccinated and unvaccinated control, possibly highlighting the AE risks with COVID-19 mRNA vaccination. Comparing the safety profile of mRNA vaccinated individuals with otherwise vaccinated individuals would enable a more relevant assessment for the safety of mRNA vaccination. We designed a comparative safety study between 18 755 and 27 895 individuals who reported to VigiBase for adverse events following immunization (AEFI) with mRNA COVID-19 and influenza vaccines, respectively, from January 1, 2020, to January 17, 2021. We employed disproportionality analysis to rapidly detect relevant safety signals and compared comparative risks of a diverse span of AEFIs for the vaccines. The safety profile of novel mRNA vaccines was divergent from that of influenza vaccines. The overall pattern suggested that systematic reactions like chill, myalgia, fatigue were more noticeable with the mRNA COVID-19 vaccine, while injection site reactogenicity events were more prevalent with the influenza vaccine. Compared to the influenza vaccine, mRNA COVID-19 vaccines demonstrated a significantly higher risk for a few manageable cardiovascular complications, such as hypertensive crisis (adjusted reporting odds ratio [ROR], 12.72; 95% confidence interval [CI], 2.47-65.54), and supraventricular tachycardia (adjusted ROR, 7.94; 95% CI, 2.62-24.00), but lower risk of neurological complications such as syncope, neuralgia, loss of consciousness, Guillain-Barre syndrome, gait disturbance, visual impairment, and dyskinesia. This study has not identified significant safety concerns regarding mRNA vaccination in real-world settings. The overall safety profile patterned a lower risk of serious AEFI following mRNA vaccines compared to influenza vaccines.", "doi": "10.1002/jmv.27424", "pmid": "34709664", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:48:34.182Z", "modified": "2021-11-29T06:07:21.030Z"}, {"entity": "publication", "iuid": "9ca3a6ec6e8b40ed879bd7983425ed90", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ca3a6ec6e8b40ed879bd7983425ed90.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ca3a6ec6e8b40ed879bd7983425ed90"}}, "title": "Comments on the Discussion Forum: Oromucosal immunomodulation as clinical spectrum mitigating factor in SARS-CoV-2 infection.", "authors": [{"family": "Smith", "given": "Michael L", "initials": "ML", "orcid": "0000-0003-4103-8614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4c9b76424464a188d2880c45a0f4303.json"}}, {"family": "Sharma", "given": "Sujata", "initials": "S"}, {"family": "Singh", "given": "Tej P", "initials": "TP"}], "type": "journal article", "published": "2021-10-28", "journal": {"title": "Scand J Immunol", "issn": "1365-3083", "pages": "e13111", "issn-l": null}, "abstract": "We read the excellent presentation by Rodriguez-Argente and coauthors and wish to add some thoughts to the discussion1 . The lactoperoxidase (LPO) system is actually the first line of mammalian, immunological defense against airborne bacterial and viral infections, including influenza and the respiratory syncytial virus (RSV)2,3 . This is not well known and some textbooks of immunology don't even mention this system.", "doi": "10.1111/sji.13111", "pmid": "34709678", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:49:35.555Z", "modified": "2021-11-01T19:49:35.593Z"}, {"entity": "publication", "iuid": "392bb2b4eb104c54bcf476998fd646df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/392bb2b4eb104c54bcf476998fd646df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/392bb2b4eb104c54bcf476998fd646df"}}, "title": "COVID-19 in lung transplant recipients: an overview of the Swedish national experience.", "authors": [{"family": "Magnusson", "given": "Jesper M", "initials": "JM"}, {"family": "Larsson", "given": "Hillevi", "initials": "H"}, {"family": "Alsaleh", "given": "Ahmed", "initials": "A"}, {"family": "Ekelund", "given": "Jan", "initials": "J"}, {"family": "Karason", "given": "Kristjan", "initials": "K"}, {"family": "Schult", "given": "Andreas", "initials": "A"}, {"family": "Friman", "given": "Vanda", "initials": "V"}, {"family": "Felldin", "given": "Marie", "initials": "M"}, {"family": "S\u00f8fteland", "given": "John Mackay", "initials": "JM"}, {"family": "Dellgren", "given": "G\u00f6ran", "initials": "G"}, {"family": "Oltean", "given": "Mihai", "initials": "M"}], "type": "journal article", "published": "2021-10-28", "journal": {"title": "Transpl Int", "issn": "1432-2277", "issn-l": null}, "abstract": "Although it is known that solid organ transplant recipients fare worse after COVID-19 infection, data on the impact of COVID-19 on clinical outcomes and allograft function in lung transplant (LTx) recipients are limited and based mainly on reports with short follow-up.\n\nIn this nationwide study, all LTx recipients with COVID-19 diagnosed from February 1st, 2020 to April 30th, 2021, were included. The patients were followed until August 1st 2021, or death. We analysed demographics, clinical features, therapeutic management, and outcomes, including lung function.\n\nForty-seven patients were identified: median age was 59 (10-78) years, 53.1% were male, and median follow-up was 194 (23-509) days. COVID-19 was asymptomatic or mild at presentation in 48.9%. Nine patients (19.1%) were vaccinated pre-COVID infection. Two patients (4.3%) died within 28 days of testing positive, and the overall survival rate was 85.1%. The patients with asymptomatic or mild symptoms had a higher median % expected forced expiratory volume during the first second than the patients with worse symptoms (p=0.004).\n\nLTx recipients develop the entire spectrum of COVID-19, and in addition to previously acknowledged risk factors, lower pre-COVID lung function was associated with more severe disease presentation.", "doi": "10.1111/tri.14148", "pmid": "34709680", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:50:31.415Z", "modified": "2021-11-01T19:50:31.428Z"}, {"entity": "publication", "iuid": "00b63ab548dd4754b5f8e8d7edad2fdd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/00b63ab548dd4754b5f8e8d7edad2fdd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/00b63ab548dd4754b5f8e8d7edad2fdd"}}, "title": "COVID-19 Vaccinations: Summary Guidance for Cancer Patients in 28 Languages: Breaking Barriers to Cancer Patient Information.", "authors": [{"family": "Davide", "given": "Mauri", "initials": "M"}, {"family": "Kamposioras", "given": "Konstantinos", "initials": "K"}, {"family": "Lampriani", "given": "Tsali", "initials": "T"}, {"family": "Mario", "given": "Dambrosio", "initials": "D"}, {"family": "Berardino", "given": "De Bari", "initials": "B"}, {"family": "Nadia", "given": "Hindi", "initials": "H"}, {"family": "Carl", "given": "Salembier", "initials": "S"}, {"family": "Joanna", "given": "Nixon", "initials": "N"}, {"family": "Dimitrios", "given": "Tzachanis", "initials": "T"}, {"family": "Flippo", "given": "Alongi", "initials": "A"}, {"family": "Hassan", "given": "Hameed", "initials": "H"}, {"family": "Antonios", "given": "Valachis", "initials": "V"}, {"family": "Konstantinos", "given": "Papadimitriou", "initials": "P"}, {"family": "Stefanie", "given": "Corradini", "initials": "C"}, {"family": "Lazar", "given": "Popovic", "initials": "P"}, {"family": "Jindrich", "given": "Kopecky", "initials": "K"}, {"family": "Andres", "given": "Rodriguez", "initials": "R"}, {"family": "Katarina", "given": "Antunac", "initials": "A"}, {"family": "Junlin", "given": "Yi", "initials": "Y"}, {"family": "Lovey", "given": "Jozsef", "initials": "J"}, {"family": "Primoz", "given": "Strojan", "initials": "S"}, {"family": "Haytham", "given": "Saraireh", "initials": "S"}, {"family": "Ranveig", "given": "R\u00f8tterud", "initials": "R"}, {"family": "Marzanna", "given": "Chojnacka", "initials": "C"}, {"family": "Olalla", "given": "Santa Cruz", "initials": "SC"}, {"family": "Natalia", "given": "Chilingirova", "initials": "C"}, {"family": "Ramon A", "given": "De Mello", "initials": "M"}, {"family": "Giovanna", "given": "Araujo Amaral", "initials": "AA"}, {"family": "Farsid", "given": "Arbabi", "initials": "A"}, {"family": "Radu", "given": "Vidra", "initials": "V"}, {"family": "Erjeta", "given": "Rapushi", "initials": "R"}, {"family": "D", "given": "Takeuchi", "initials": "T"}, {"family": "Chirstos", "given": "Christopoulos", "initials": "C"}, {"family": "Irina", "given": "Ivanova", "initials": "I"}, {"family": "Igor", "given": "Djan", "initials": "D"}, {"family": "Branka", "given": "Petricevic", "initials": "P"}, {"family": "Francesco", "given": "Cellini", "initials": "C"}, {"family": "Iglika", "given": "Mihaylova", "initials": "M"}, {"family": "Natalija", "given": "Dedic Plavetic", "initials": "DP"}, {"family": "Cvetka", "given": "Gra\u0161i\u010d Kuhar", "initials": "GK"}, {"family": "Elena", "given": "Takeuchi", "initials": "T"}, {"family": "Pantelis", "given": "Kountourakis", "initials": "K"}, {"family": "Panagiotis", "given": "Ntellas", "initials": "N"}, {"family": "Ioanna", "given": "Gazouli", "initials": "G"}, {"family": "Stefania", "given": "Gkoura", "initials": "G"}, {"family": "Salih", "given": "Yuce", "initials": "Y"}, {"family": "Er", "given": "\u00d6zlem", "initials": "\u00d6"}, {"family": "Yasmina", "given": "Chait", "initials": "C"}, {"family": "Kumaran", "given": "Gireesh", "initials": "G"}, {"family": "Orges", "given": "Spahiu", "initials": "S"}, {"family": "Aasim", "given": "Yusuf", "initials": "Y"}, {"family": "Gono", "given": "Paulina", "initials": "P"}, {"family": "Apostolidis", "given": "Kathi", "initials": "K"}, {"family": "Tolia", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-10-28", "journal": {"title": "Rev Recent Clin Trials", "issn": "1876-1038", "issn-l": null}, "abstract": "Covid-19 vaccination has started in the majority of the countries at the global level. Cancer patients are at high risk for infection, serious illness, and death from COVID-19 and need vaccination guidance and support. Guidance availability in the English language only is a major limit for recommendations' delivery and their application in the world's population and generates information inequalities across the different populations.\n\nMost of the available COVID-19 vaccination guidance for cancer patients was screened and scrutinized by the European Cancer Patients Coalition (ECPC) and an international oncology panel of 52 physicians from 33 countries.\n\nA summary guidance was developed and provided in 28 languages in order to reach more than 70 percent of the global population.\n\nLanguage barrier and e-guidance availability in the native language are the most important barriers when communicating with patients. E-guidance availability in various native languages should be considered a major priority by international medical and health organizations that are communicating with patients at the global level.<\/P>.", "doi": "10.2174/1574887116666211028145848", "pmid": "34967300", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "RRCT-EPUB-118603"}], "notes": [], "created": "2022-01-04T14:59:21.002Z", "modified": "2022-01-04T14:59:31.343Z"}, {"entity": "publication", "iuid": "7d83002c4ecd4eef919999fe1fdaca8a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d83002c4ecd4eef919999fe1fdaca8a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d83002c4ecd4eef919999fe1fdaca8a"}}, "title": "The impact of the COVID-19 pandemic on autoimmune diagnostics in Europe: A lesson to be learned.", "authors": [{"family": "Nagy", "given": "Eszter", "initials": "E"}, {"family": "Infantino", "given": "Maria", "initials": "M"}, {"family": "Bizzaro", "given": "Nicola", "initials": "N"}, {"family": "Andreeva", "given": "Hristina", "initials": "H"}, {"family": "Bontkes", "given": "Hetty J", "initials": "HJ"}, {"family": "Bossuyt", "given": "Xavier", "initials": "X"}, {"family": "Fabien", "given": "Nicole", "initials": "N"}, {"family": "Fischer", "given": "Katarzyna", "initials": "K"}, {"family": "Heijnen", "given": "Ingmar A F M", "initials": "IAFM"}, {"family": "Herold", "given": "Manfred", "initials": "M"}, {"family": "Kozmar", "given": "Ana", "initials": "A"}, {"family": "Kuhi", "given": "Liisa", "initials": "L"}, {"family": "L\u00f3pez-Hoyos", "given": "Marcos", "initials": "M"}, {"family": "Pullerits", "given": "Rille", "initials": "R"}, {"family": "Sousa", "given": "Maria Jos\u00e9 Rego", "initials": "MJR"}, {"family": "Tsirogianni", "given": "Alexandra", "initials": "A"}, {"family": "Damoiseaux", "given": "Jan", "initials": "J"}, {"family": "European Autoimmunity Standardisation Initiative", "given": "", "initials": ""}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "Autoimmun Rev", "issn": "1873-0183", "pages": "102985", "issn-l": null}, "abstract": "The first wave of COVID-19 pandemic has disrupted almost all areas of the health care services to some extent throughout the world. Although the negative impact of COVID-19 on patients with autoimmune diseases has also been recognized, available data in this regard are limited. In the current study of the European Autoimmunity Standardisation Initiative (EASI) we aimed to provide reliable data on the extent of the impact of COVID-19 pandemic on test requests for different autoantibodies in European countries.\n\nData on test numbers and on the number of positive results were collected in 97 clinical laboratories from 15 European countries on a monthly basis for the year before (2019) and the year during (2020) the COVID-19 pandemic.\n\nA reduction in the number of autoantibody tests was observed in all European countries in the year 2020 compared to 2019. The reduction affected all autoantibody tests with an overall decrease of 13%, ranging from 1.4% (Switzerland) to 25.5% (Greece). In all countries, the decrease was most pronounced during the first wave of the pandemic (March-May 2020) with an overall decrease in those three months of 45.2%. The most affected autoantibodies were those commonly requested by general practitioners (anti-tTG IgA (-71%), RF IgM (-66%) and ACPA (-61%)). In the second wave of the pandemic (October-December 2020) the decrease was less pronounced (6.8%). With respect to the rate of positive results, subtle differences were observed for distinct autoantibodies during the pandemic, but the total rate of positive results was similar in both years.\n\nOur study demonstrated a strong decrease in autoantibody requests during the first wave of the COVID-19 pandemic in 15 European countries. The second wave was characterized by a less pronounced impact, with some participating countries hardly affected, while some other countries experienced a second decline. The decrease was clearly associated with the level of lock-down and with the required adjustments in the health care systems in different countries, supporting the importance of an effective strategy for the coordination of autoimmune testing in challenging situations as the COVID-19 pandemic.", "doi": "10.1016/j.autrev.2021.102985", "pmid": "34718167", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1568-9972(21)00265-2"}], "notes": [], "created": "2021-11-01T19:53:22.570Z", "modified": "2021-11-01T19:53:22.584Z"}, {"entity": "publication", "iuid": "9f874862068d4cd791f845d47d2425ce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f874862068d4cd791f845d47d2425ce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f874862068d4cd791f845d47d2425ce"}}, "title": "The COVID-19 pandemic and ANCA-associated vasculitis - reports from the EUVAS meeting and EUVAS education forum.", "authors": [{"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Geetha", "given": "Duvuru", "initials": "D"}, {"family": "Smith", "given": "Rona M", "initials": "RM"}, {"family": "Egan", "given": "Allyson C", "initials": "AC"}, {"family": "Bajema", "given": "Ingeborg M", "initials": "IM"}, {"family": "Sch\u00f6nermarck", "given": "Ulf", "initials": "U"}, {"family": "Mahr", "given": "Alfred", "initials": "A"}, {"family": "Anders", "given": "Hans-Joachim", "initials": "HJ"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Cid", "given": "Maria C", "initials": "MC"}, {"family": "Jayne", "given": "David R W", "initials": "DRW"}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "Autoimmun Rev", "issn": "1873-0183", "pages": "102986", "issn-l": null}, "abstract": "The Coronavirus Disease 2019 (COVID-19) pandemic influenced the management of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. A paucity of data exists on outcome of patients with vasculitis following COVID-19, but mortality is higher than in the general population and comparable to patients undergoing haemodialysis or kidney transplant recipients (reported mortality rates of 20-25%). Delays in diagnosis have been reported, which are associated with sequelae such as dialysis-dependency. Management of ANCA-associated vasculitis has not changed with the aim to suppress disease activity and reduce burden of disease. The use of rituximab, an important and widely used agent, is associated with a more severe hospital course of COVID-19 and absence of antibodies following severe acute respiratory syndrome (SARS)-CoV-2 infections, which prone patients to re-infection. Reports on vaccine antibody response are scarce at the moment, but preliminary findings point towards an impaired immune response, especially when patients receive rituximab as part of their treatment. Seropositivity was reported in less than 20% of patients when rituximab was administered within the prior six months, and the antibody response correlated with CD19+ B-cell repopulation. A delay in maintenance doses, if disease activity allows, has been suggested using a CD19+ B-cell guided strategy. Other immunosuppressive measures, which are used in ANCA-associated vasculitis, also impair humoral and cellular vaccine responses. Regular measurements of vaccine response or a healthcare-policy time-based strategy are indicated to provide additional doses (\"booster\") of COVID-19 vaccines. This review summarizes a recent educational forum and a recent virtual meeting of the European Vasculitis Society (EUVAS) focusing on COVID-19.", "doi": "10.1016/j.autrev.2021.102986", "pmid": "34718165", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1568-9972(21)00266-4"}], "notes": [], "created": "2021-11-01T19:53:00.767Z", "modified": "2021-11-01T19:53:00.781Z"}, {"entity": "publication", "iuid": "56a3ee64de654942a1344e5dd2026dd1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56a3ee64de654942a1344e5dd2026dd1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56a3ee64de654942a1344e5dd2026dd1"}}, "title": "Susceptibility of Dog, Hamster, and Mouse Cells to the Replication-Competent Adenovirus 11p E1/E3 Green Fluorescence Protein Vector Has Implications for the Selection of Animal Vaccine Models.", "authors": [{"family": "Gokumakulapalle", "given": "Madhuri", "initials": "M"}, {"family": "Wang", "given": "Li", "initials": "L"}, {"family": "Mei", "given": "Ya-Fang", "initials": "YF"}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "Front Microbiol", "issn": "1664-302X", "volume": "12", "pages": "698999", "issn-l": null}, "abstract": "Human adenovirus (Ad)-vectored vaccines require viruses that can internalize into host cells and express the vaccine antigen. Evaluation of the expressed antigen in animal cells is a critical step in preclinical trials of viral vaccines. Due to the species specificity of Ads, it is difficult to find a suitable animal model. Thus, in this study, we compared the efficacy of Ad 11 prototype (Ad11p)-mediated green fluorescence protein (GFP) expression in cell lines of dog (MDCK), hamster (CHO), and mouse (McCoy and C127). Although these cell lines did not express the known primary cellular receptors for Ad11p virus infection (i.e., CD46), Ad11pE1GFP could infect and express GFP with various efficacies. For instance, it manifested relatively higher GFP expression in MDCK than in CHO, McCoy, and C127. However, infection leading to efficient viral release was not observed in any of the studied cell lines. The apparent differences were attributed to particularities of mouse and hamster cell lines, which might have led to the repression of viral DNA synthesis and to the low level of GFP expression mediated by Ad11pe3GFP. Moreover, our results revealed that undetectable hexon protein hampered the assembly of virus particles in CHO and MDCK cells. Ad11p differed from Ad5 in the ability for viral DNA synthesis when infecting CHO cells. Although a defective Ad has been successfully developed for SARS-CoV-2 vaccines in clinical applications, it has been difficult to generate one that can be used as an oral SARS-CoV-2 vaccine. Fortunately, our replication-competent Ad 11p vector might solve this problem. Regarding the use of Ad-vector candidates for vaccine purposes, this study demonstrates the selection of animal cell lines and determination of suitable virus doses in in vitro experiments.", "doi": "10.3389/fmicb.2021.698999", "pmid": "34777270", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8578929"}], "notes": [], "created": "2021-11-26T14:27:58.792Z", "modified": "2021-11-26T14:27:58.830Z"}, {"entity": "publication", "iuid": "dc2be6dc17694aa697b4280a36f1bda0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dc2be6dc17694aa697b4280a36f1bda0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dc2be6dc17694aa697b4280a36f1bda0"}}, "title": "Structural Modeling on the Determinants of Effectiveness of SOPs Containing COVID-19 in Mass Gatherings.", "authors": [{"family": "Basit", "given": "Abdul", "initials": "A"}, {"family": "Scholz", "given": "Miklas", "initials": "M"}, {"family": "Niazi", "given": "Abdul Aziz Khan", "initials": "AAK"}, {"family": "Qazi", "given": "Tehmina Fiaz", "initials": "TF"}, {"family": "Shaukat", "given": "Muhammad Zeeshan", "initials": "MZ"}, {"family": "Rao", "given": "Zia-Ur-Rehman", "initials": "ZU"}, {"family": "Mahmood", "given": "Asif", "initials": "A"}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "755221", "issn-l": "1664-1078"}, "abstract": "The study is aimed to analyze the determinants of the effectiveness of SOPs in mass gatherings for containing COVID-19. The overall design of the study involves a literature review, data collection by field survey, structural modeling, and analysis. The study is built on the experts' opinion of a focus group (representing people who recently participated in and are responsible for mass gatherings). The study uses the discussion of the literature review to identify the determinants, interpretive structural modeling (ISM) for developing and analyzing a structural model, and Matrice d'Impacts Croises Multiplication Appliqu\u00e9e a un Classement (MICMAC) for corroboration of results of the ISM/classification of determinants. From the literature review, a list of determinants is generated and verified by a panel of experts. The results of the ISM revealed that the determinants \"legal environment of the country,\" \"practicability of SOPs,\" \"perceived benefit of adapting SOPs,\" and \"possibilities of avoiding gathering\" occupied the top of the model, therefore, they are less critical determinants, whereas \"nature of gathering\" occupied the bottom of the model, and is thus the most critical determinant. The remaining determinants form the middle of the model, and are therefore moderately severe. The results of MICMAC show that the determinant \"perceived benefit of adapting SOPs\" is dependent, \"nature of gathering\" is independent, and all others are linked. The results of MICMAC implicitly substantiate the findings of the ISM. The overall results of the study show that \"nature of gathering\" is the key determinant. This research does not require a priori theory since it is a theory-building study that uses an inductive approach. It is based on real data and it is useful for local authorities, organizers, participants (attendees/visitors) of mass gatherings, health officials/regulators, researchers, and the community at large. This study has fundamental importance for planning and preparing for such events while ensuring the minimum risk of COVID-19 transmission.", "doi": "10.3389/fpsyg.2021.755221", "pmid": "34777157", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC8578903"}], "notes": [], "created": "2021-11-26T14:28:19.315Z", "modified": "2021-11-26T14:28:19.329Z"}, {"entity": "publication", "iuid": "e5bae109b5e84a9687da1506ae5c14c8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e5bae109b5e84a9687da1506ae5c14c8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e5bae109b5e84a9687da1506ae5c14c8"}}, "title": "SARS-CoV-2 and pregnancy outcomes under universal and non-universal testing in Sweden: register-based nationwide cohort study.", "authors": [{"family": "Stephansson", "given": "Olof", "initials": "O"}, {"family": "Pasternak", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Ahlberg", "given": "Mia", "initials": "M"}, {"family": "Hervius Askling", "given": "Helena", "initials": "H"}, {"family": "Aronsson", "given": "Bernice", "initials": "B"}, {"family": "Appelqvist", "given": "Emma", "initials": "E"}, {"family": "Jonsson", "given": "Jerker", "initials": "J"}, {"family": "Sengpiel", "given": "Verena", "initials": "V"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Norman", "given": "Mikael", "initials": "M"}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}, {"family": "Neovius", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "BJOG", "issn": "1471-0528", "issn-l": null}, "abstract": "To assess associations of SARS-CoV-2-infection and pregnancy outcomes considering testing policy and test-positivity-to-delivery-interval.\n\nNationwide cohort study.\n\nSweden.\n\nFrom the Pregnancy-Register we identified 88,593 singleton births, March 11, 2020-January 31, 2021, linked to data on SARS-CoV-2-positivity from the Public Health Agency, and information on neonatal care admission from the Neonatal Quality-Register. Adjusted odds ratios (aORs) were estimated stratified by testing-policy and test-positivity-to-delivery-interval.\n\n5-minute Apgar score, neonatal care admission, stillbirth and preterm birth.\n\nDuring pregnancy, SARS-CoV-2 test-positivity was 5.4% (794/14,665) under universal and 1.9% (1402/73,928) under non-universal testing. There were generally lower risks associated with SARS-CoV-2 under universal than non-universal testing. In women testing positive >10 days from delivery, generally no significant differences in risk were observed under either testing policy. Neonatal care admission was more common (15.3% vs. 8.0%; aOR 2.24, 1.62-3.11) in women testing positive \u226410 days before delivery under universal testing. There was no significant association with 5-minute Apgar score <7 (1.0% vs. 1.7%; aOR 0.64, 0.24-1.72) or stillbirth (0.3% vs. 0.4%; aOR 0.72, 0.10-5.20). Compared with term births (2.1%), test-positivity was higher in medically indicated preterm (5.7%; aOR 2.70, 1.60-4.58) but not significantly increased in spontaneous preterm birth (2.3%; aOR 1.12, 0.62-2.02).\n\nTesting policy and timing of test positivity impact associations between SARS-CoV-2 positivity and pregnancy outcomes. Under non-universal testing, women with complications near delivery are more likely to be tested than women without complications, thereby inflating any association with adverse pregnancy outcomes compared to findings under universal testing.", "doi": "10.1111/1471-0528.16990", "pmid": "34706148", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:45:48.410Z", "modified": "2021-11-01T19:45:54.393Z"}, {"entity": "publication", "iuid": "5924041381054e26b5f234589e3c0477", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5924041381054e26b5f234589e3c0477.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5924041381054e26b5f234589e3c0477"}}, "title": "NMR-Based Analysis of Nanobodies to SARS-CoV-2 Nsp9 Reveals a Possible Antiviral Strategy Against COVID-19.", "authors": [{"family": "Esposito", "given": "Gennaro", "initials": "G"}, {"family": "Hunashal", "given": "Yamanappa", "initials": "Y"}, {"family": "Percipalle", "given": "Mathias", "initials": "M"}, {"family": "Venit", "given": "Tomas", "initials": "T"}, {"family": "Dieng", "given": "Mame Massar", "initials": "MM"}, {"family": "Fogolari", "given": "Federico", "initials": "F"}, {"family": "Hassanzadeh", "given": "Gholamreza", "initials": "G"}, {"family": "Piano", "given": "Fabio", "initials": "F"}, {"family": "Gunsalus", "given": "Kristin C", "initials": "KC"}, {"family": "Idaghdour", "given": "Youssef", "initials": "Y"}, {"family": "Percipalle", "given": "Piergiorgio", "initials": "P"}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "Adv Biol (Weinh)", "issn": "2701-0198", "pages": "e2101113", "issn-l": null}, "abstract": "Following the entry into the host cell, SARS-CoV-2 replication is mediated by the replication transcription complex (RTC) assembled through a number of nonstructural proteins (Nsps). A monomeric form of Nsp9 is particularly important for RTC assembly and function. In the present study, 136 unique nanobodies targeting Nsp9 are generated. Several nanobodies belonging to different B-cell lineages are expressed, purified, and characterized. Results from immunoassays applied to purified Nsp9 and neat saliva from coronavirus disease (COVID-19) patients show that these nanobodies effectively and specifically recognize both recombinant and endogenous Nsp9. Nuclear magnetic resonance analyses supported by molecular dynamics reveal a composite Nsp9 oligomerization pattern and demonstrate that both nanobodies stabilize the tetrameric form of wild-type Nsp9 also identifying the epitopes on the tetrameric assembly. These results can have important implications in the potential use of these nanobodies to combat viral replication.", "doi": "10.1002/adbi.202101113", "pmid": "34705339", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:39:08.657Z", "modified": "2021-11-01T19:44:19.968Z"}, {"entity": "publication", "iuid": "49a2fc525b8946b7a7913b62b72d1849", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49a2fc525b8946b7a7913b62b72d1849.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49a2fc525b8946b7a7913b62b72d1849"}}, "title": "Infection of Brain Pericytes Underlying Neuropathology of COVID-19 Patients.", "authors": [{"family": "Bocci", "given": "Matteo", "initials": "M", "orcid": "0000-0002-8774-0006", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c3ba1259efde4518bcdb59555b8a536e.json"}}, {"family": "Oudenaarden", "given": "Clara", "initials": "C", "orcid": "0000-0002-5466-0755", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75886cf472ee4475b742994021bb64c8.json"}}, {"family": "S\u00e0enz-Sard\u00e0", "given": "Xavier", "initials": "X"}, {"family": "Simr\u00e9n", "given": "Joel", "initials": "J", "orcid": "0000-0001-5081-6604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00690c8e16a545aea824cdf580837500.json"}}, {"family": "Ed\u00e9n", "given": "Arvid", "initials": "A"}, {"family": "Sj\u00f6lund", "given": "Jonas", "initials": "J", "orcid": "0000-0002-6992-3415", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5bf3daabd44d45efa72697934ad730b7.json"}}, {"family": "M\u00f6ller", "given": "Christina", "initials": "C"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Englund", "given": "Elisabet", "initials": "E", "orcid": "0000-0002-2708-2443", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b5ac92c5d404356b843be1973ea4922.json"}}, {"family": "Pietras", "given": "Kristian", "initials": "K", "orcid": "0000-0001-6738-4705", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5d4c2cbb9ca49a7a9664c83e383c695.json"}}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "issn-l": null, "volume": "22", "issue": "21", "pages": "11622"}, "abstract": "A wide range of neurological manifestations have been associated with the development of COVID-19 following SARS-CoV-2 infection. However, the etiology of the neurological symptomatology is still largely unexplored. Here, we used state-of-the-art multiplexed immunostaining of human brains (n = 6 COVID-19, median age = 69.5 years; n = 7 control, median age = 68 years) and demonstrated that expression of the SARS-CoV-2 receptor ACE2 is restricted to a subset of neurovascular pericytes. Strikingly, neurological symptoms were exclusive to, and ubiquitous in, patients that exhibited moderate to high ACE2 expression in perivascular cells. Viral dsRNA was identified in the vascular wall and paralleled by perivascular inflammation, as signified by T cell and macrophage infiltration. Furthermore, fibrinogen leakage indicated compromised integrity of the blood-brain barrier. Notably, cerebrospinal fluid from additional 16 individuals (n = 8 COVID-19, median age = 67 years; n = 8 control, median age = 69.5 years) exhibited significantly lower levels of the pericyte marker PDGFR\u03b2 in SARS-CoV-2-infected cases, indicative of disrupted pericyte homeostasis. We conclude that pericyte infection by SARS-CoV-2 underlies virus entry into the privileged central nervous system space, as well as neurological symptomatology due to perivascular inflammation and a locally compromised blood-brain barrier.", "doi": "10.3390/ijms222111622", "pmid": "34769052", "labels": {"Type: Journal article": null, "Category: Health": null, "Funder: H2020": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC8583965"}, {"db": "pii", "key": "ijms222111622"}], "notes": [], "created": "2021-11-26T15:11:17.222Z", "modified": "2023-06-19T14:45:33.615Z"}, {"entity": "publication", "iuid": "4deb3e9fe22f428bb2a86ea93ae98cc8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4deb3e9fe22f428bb2a86ea93ae98cc8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4deb3e9fe22f428bb2a86ea93ae98cc8"}}, "title": "Experience of the COVID-19 pandemic as lived by patients with hip and knee osteoarthritis: an Italian qualitative study.", "authors": [{"family": "Battista", "given": "Simone", "initials": "S", "orcid": "0000-0002-7471-1951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/787958b5579949919d584b1ef60e6eb2.json"}}, {"family": "Dell'Isola", "given": "Andrea", "initials": "A", "orcid": "0000-0002-0319-458X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d8ea417b7c447f8bc4da9f47f9feb39.json"}}, {"family": "Manoni", "given": "Mattia", "initials": "M"}, {"family": "Englund", "given": "Martin", "initials": "M"}, {"family": "Palese", "given": "Alvisa", "initials": "A", "orcid": "0000-0002-3508-844X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea400153bf344f98a5e06367b0442e17.json"}}, {"family": "Testa", "given": "Marco", "initials": "M"}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "10", "pages": "e053194", "issn-l": "2044-6055"}, "abstract": "To examine the experience of the COVID-19 pandemic as lived by people with hip and knee osteoarthritis (OA), in Italy.\n\nA qualitative study based on semi-structured interviews.\n\nUrban and suburban areas in northern Italy.\n\nA total of 11 people with OA were enrolled through a purposeful sampling and completed the study.\n\nThe experience of Italian people with OA during the COVID-19 pandemic.\n\nFour themes were brought to the forefront from the analysis of the interviews. (1) Being Stressed for the Limited Social Interactions and for the Family Members at High Risk of Infection, as the interviewees were frustrated because they could not see their loved ones or felt a sense of apprehension for their relatives. (2) Recurring Strategies to Cope with the Pandemic such as an active acceptance towards the situation. (3) Being Limited in the Possibility of Undergoing OA Complementary Treatments and Other Routine Medical Visits. (4) Being Unaware of the Importance of Physical Activity as First-Line Interventions which was an attitude already present before the pandemic.\n\nThe COVID-19 pandemic and related restrictions impacted the quality of life and the care of individuals with hip and knee OA. The social sphere seemed to be the most hindered. However, the interviewees developed a good level of acceptance to deal with the pandemic. When it came to their care, they faced a delay of routine medical visits not related to OA and of other complementary treatments (eg, physical therapies) to manage OA. Finally, a controversial result that emerged from these interviews was that first-line interventions for OA (ie, therapeutic exercise) was not sought by the interviewees, regardless of the restrictions dictated by the pandemic. Policy-making strategies are thus necessary to support the awareness of the importance of such interventions.", "doi": "10.1136/bmjopen-2021-053194", "pmid": "34706962", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-053194"}, {"db": "pmc", "key": "PMC8551748"}], "notes": [], "created": "2021-11-01T19:47:22.538Z", "modified": "2021-11-01T19:47:22.639Z"}, {"entity": "publication", "iuid": "e510117a965e4b958a1a37c706e5f11e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e510117a965e4b958a1a37c706e5f11e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e510117a965e4b958a1a37c706e5f11e"}}, "title": "Brain MRI and neuropsychological findings at long-term follow-up after COVID-19 hospitalisation: an observational cohort study.", "authors": [{"family": "Hellgren", "given": "Lovisa", "initials": "L", "orcid": "0000-0003-4099-9456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45a3650707574e258665a54751ae26ba.json"}}, {"family": "Birberg Thornberg", "given": "Ulrika", "initials": "U"}, {"family": "Samuelsson", "given": "Kersti", "initials": "K"}, {"family": "Levi", "given": "Richard", "initials": "R"}, {"family": "Divanoglou", "given": "Anestis", "initials": "A"}, {"family": "Blystad", "given": "Ida", "initials": "I"}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "10", "pages": "e055164", "issn-l": "2044-6055"}, "abstract": "To report findings on brain MRI and neurocognitive function, as well as persisting fatigue at long-term follow-up after COVID-19 hospitalisation in patients identified as high risk for affection of the central nervous system.\n\nAmbidirectional observational cohort study.\n\nAll 734 patients from a regional population in Sweden with a laboratory-confirmed COVID-19 diagnosis admitted to hospital during the period 1 March to 31 May 2020.\n\nA subgroup (n=185) with persisting symptoms still interfering with daily life at a telephone follow-up 4 months after discharge were invited for a medical and neuropsychological evaluation. Thirty-five of those who were assessed with a neurocognitive test battery at the clinical visit, and presented a clinical picture concerning for COVID-19-related brain pathology, were further investigated by brain MRI.\n\nFindings on brain MRI, neurocognitive test results and reported fatigue.\n\nTwenty-five patients (71%) had abnormalities on MRI; multiple white matter lesions were the most common finding. Sixteen patients (46%) demonstrated impaired neurocognitive function, of which 10 (29%) had severe impairment. Twenty-six patients (74%) reported clinically significant fatigue. Patients with abnormalities on MRI had a lower Visuospatial Index (p=0.031) compared with the group with normal MRI findings.\n\nIn this group of patients selected to undergo MRI after a clinical evaluation, a majority of patients had abnormal MRI and/or neurocognitive test results. Abnormal findings were not restricted to patients with severe disease.", "doi": "10.1136/bmjopen-2021-055164", "pmid": "34706965", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-055164"}, {"db": "pmc", "key": "PMC8551746"}], "notes": [], "created": "2021-11-01T19:47:38.514Z", "modified": "2021-11-01T19:47:38.573Z"}, {"entity": "publication", "iuid": "8ea921e8ebb1479ca21c1bc2cb4a4aba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ea921e8ebb1479ca21c1bc2cb4a4aba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ea921e8ebb1479ca21c1bc2cb4a4aba"}}, "title": "The impact of a COVID-19 lockdown on work productivity under good and poor compliance.", "authors": [{"family": "Ohrnberger", "given": "Julius", "initials": "J"}, {"family": "Segal", "given": "Alexa Blair", "initials": "AB"}, {"family": "Forchini", "given": "Giovanni", "initials": "G"}, {"family": "Miraldo", "given": "Marisa", "initials": "M"}, {"family": "Skarp", "given": "Janetta", "initials": "J"}, {"family": "Nedjati-Gilani", "given": "Gemma", "initials": "G"}, {"family": "Laydon", "given": "Daniel J", "initials": "DJ"}, {"family": "Ghani", "given": "Azra", "initials": "A"}, {"family": "Ferguson", "given": "Neil M", "initials": "NM"}, {"family": "Hauck", "given": "Katharina", "initials": "K"}], "type": "journal article", "published": "2021-10-26", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": "31", "issue": "5", "pages": "1009-1015"}, "abstract": "In response to the COVID-19 pandemic, governments across the globe have imposed strict social distancing measures. Public compliance to such measures is essential for their success, yet the economic consequences of compliance are unknown. This is the first study to analyze the effects of good compliance compared with poor compliance to a COVID-19 suppression strategy (i.e. lockdown) on work productivity.\r\n\r\nWe estimate the differences in work productivity comparing a scenario of good compliance with one of poor compliance to the UK government COVID-19 suppression strategy. We use projections of the impact of the UK suppression strategy on mortality and morbidity from an individual-based epidemiological model combined with an economic model representative of the labour force in Wales and England.\r\n\r\nWe find that productivity effects of good compliance significantly exceed those of poor compliance and increase with the duration of the lockdown. After 3 months of the lockdown, work productivity in good compliance is \u00a3398.58 million higher compared with that of poor compliance; 75% of the differences is explained by productivity effects due to morbidity and non-health reasons and 25% attributed to avoided losses due to pre-mature mortality.\r\n\r\nGood compliance to social distancing measures exceeds positive economic effects, in addition to health benefits. This is an important finding for current economic and health policy. It highlights the importance to set clear guidelines for the public, to build trust and support for the rules and if necessary, to enforce good compliance to social distancing measures.", "doi": "10.1093/eurpub/ckab138", "pmid": "34358291", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6343457"}, {"db": "pmc", "key": "PMC8385936"}], "notes": [], "created": "2021-08-11T14:38:19.897Z", "modified": "2021-11-18T13:28:17.534Z"}, {"entity": "publication", "iuid": "386040da818e4b41895292a89e9a70d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/386040da818e4b41895292a89e9a70d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/386040da818e4b41895292a89e9a70d9"}}, "title": "Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure", "authors": [{"family": "Rando", "given": "Halie M", "initials": "HM", "orcid": "0000-0001-7688-1770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b5a9f4ec1bd48579abca9895dab3ea7.json"}}, {"family": "MacLean", "given": "Adam L", "initials": "AL"}, {"family": "Lee", "given": "Alexandra J", "initials": "AJ"}, {"family": "Lordan", "given": "Ronan", "initials": "R", "orcid": "0000-0001-9668-3368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0126a49dfcdf49fcb53041fbdcd91706.json"}}, {"family": "Ray", "given": "Sandipan", "initials": "S"}, {"family": "Bansal", "given": "Vikas", "initials": "V"}, {"family": "Skelly", "given": "Ashwin N", "initials": "AN"}, {"family": "Sell", "given": "Elizabeth", "initials": "E"}, {"family": "Dziak", "given": "John J", "initials": "JJ"}, {"family": "Shinholster", "given": "Lamonica", "initials": "L"}, {"family": "D\u2019Agostino McGowan", "given": "Lucy", "initials": "L"}, {"family": "Ben Guebila", "given": "Marouen", "initials": "M"}, {"family": "Wellhausen", "given": "Nils", "initials": "N"}, {"family": "Knyazev", "given": "Sergey", "initials": "S"}, {"family": "Boca", "given": "Simina M", "initials": "SM"}, {"family": "Capone", "given": "Stephen", "initials": "S"}, {"family": "Qi", "given": "Yanjun", "initials": "Y"}, {"family": "Park", "given": "YoSon", "initials": "Y"}, {"family": "Mai", "given": "David", "initials": "D"}, {"family": "Sun", "given": "Yuchen", "initials": "Y"}, {"family": "Boerckel", "given": "Joel D", "initials": "JD"}, {"family": "Brueffer", "given": "Christian", "initials": "C"}, {"family": "Byrd", "given": "James Brian", "initials": "JB"}, {"family": "Kamil", "given": "Jeremy P", "initials": "JP", "orcid": "0000-0001-8422-7656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa225803435a4d7b803176e2ccfbef19.json"}}, {"family": "Wang", "given": "Jinhui", "initials": "J"}, {"family": "Velazquez", "given": "Ryan", "initials": "R"}, {"family": "Szeto", "given": "Gregory L", "initials": "GL"}, {"family": "Barton", "given": "John P", "initials": "JP"}, {"family": "Goel", "given": "Rishi Raj", "initials": "RR"}, {"family": "Mangul", "given": "Serghei", "initials": "S"}, {"family": "Lubiana", "given": "Tiago", "initials": "T"}, {"family": "Gitter", "given": "Anthony", "initials": "A"}, {"family": "Greene", "given": "Casey S", "initials": "CS", "orcid": "0000-0001-8713-9213", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42aaaac8b65642538f28f9cd2045ab8d.json"}}, {"family": "None", "given": "", "initials": ""}], "type": "journal-article", "published": "2021-10-26", "journal": {"title": "mSystems", "issn": "2379-5077", "issn-l": null, "volume": "6", "issue": "5", "pages": null}, "abstract": null, "doi": "10.1128/msystems.00095-21", "pmid": null, "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:37:06.978Z", "modified": "2021-11-18T14:28:27.267Z"}, {"entity": "publication", "iuid": "70243d223f1848d1967e89a92973652a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70243d223f1848d1967e89a92973652a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70243d223f1848d1967e89a92973652a"}}, "title": "Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms.", "authors": [{"family": "Zhu", "given": "Rongjia", "initials": "R", "orcid": "0000-0003-3165-2813", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6f44e080388045cfb694fe567aa26b16.json"}}, {"family": "Yan", "given": "Tingdong", "initials": "T"}, {"family": "Feng", "given": "Yingmei", "initials": "Y", "orcid": "0000-0001-5248-0155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975beb8e77c84ab1b4de7b8faaf1c24b.json"}}, {"family": "Liu", "given": "Yan", "initials": "Y"}, {"family": "Cao", "given": "Hongcui", "initials": "H", "orcid": "0000-0002-6604-6867", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2296fd365154488bba2c052485f370d0.json"}}, {"family": "Peng", "given": "Gongxin", "initials": "G"}, {"family": "Yang", "given": "Yanlei", "initials": "Y"}, {"family": "Xu", "given": "Zhen", "initials": "Z"}, {"family": "Liu", "given": "Jingqi", "initials": "J"}, {"family": "Hou", "given": "Wei", "initials": "W"}, {"family": "Wang", "given": "Xiaoyue", "initials": "X"}, {"family": "Li", "given": "Zhe", "initials": "Z"}, {"family": "Deng", "given": "Luchan", "initials": "L"}, {"family": "Wang", "given": "Shihua", "initials": "S"}, {"family": "Li", "given": "Jing", "initials": "J"}, {"family": "Han", "given": "Qin", "initials": "Q"}, {"family": "Li", "given": "Hongling", "initials": "H"}, {"family": "Shan", "given": "Guangliang", "initials": "G"}, {"family": "Cao", "given": "Yinghao", "initials": "Y"}, {"family": "An", "given": "Xingyan", "initials": "X"}, {"family": "Yan", "given": "Jianshe", "initials": "J"}, {"family": "Zhang", "given": "Zhonghui", "initials": "Z"}, {"family": "Li", "given": "Huafei", "initials": "H"}, {"family": "Qu", "given": "Xuebin", "initials": "X"}, {"family": "Zhu", "given": "Jiaqi", "initials": "J"}, {"family": "Zhou", "given": "Shumin", "initials": "S"}, {"family": "Wang", "given": "Jiao", "initials": "J"}, {"family": "Zhang", "given": "Fengchun", "initials": "F"}, {"family": "Gao", "given": "Jinming", "initials": "J"}, {"family": "Jin", "given": "Ronghua", "initials": "R", "orcid": "0000-0002-6035-2425", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af992bd4085247d68012ae3996daa0bd.json"}}, {"family": "Xu", "given": "Dayong", "initials": "D"}, {"family": "Ma", "given": "Yan-Qing", "initials": "YQ", "orcid": "0000-0002-0573-7701", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b1665bdbfe34e6ca10bbd4dfd63470f.json"}}, {"family": "Huang", "given": "Tao", "initials": "T"}, {"family": "Peng", "given": "Shuang", "initials": "S"}, {"family": "Zheng", "given": "Zhi", "initials": "Z"}, {"family": "Stambler", "given": "Ilia", "initials": "I"}, {"family": "Gilson", "given": "Eric", "initials": "E"}, {"family": "Lim", "given": "Lee Wei", "initials": "LW"}, {"family": "Moskalev", "given": "Alexey", "initials": "A", "orcid": "0000-0002-3248-1633", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18eb8535023143ee9ec9f80ca3dc7185.json"}}, {"family": "Cano", "given": "Antonio", "initials": "A"}, {"family": "Chakrabarti", "given": "Sasanka", "initials": "S"}, {"family": "Ulfhake", "given": "Brun", "initials": "B"}, {"family": "Su", "given": "Huanxing", "initials": "H"}, {"family": "Xu", "given": "Haoying", "initials": "H"}, {"family": "Xu", "given": "Sihuan", "initials": "S"}, {"family": "Wei", "given": "Feng", "initials": "F"}, {"family": "Brown-Borg", "given": "Holly M", "initials": "HM"}, {"family": "Min", "given": "Kyung-Jin", "initials": "KJ"}, {"family": "Ellison-Hughes", "given": "Georgina", "initials": "G"}, {"family": "Caruso", "given": "Calogero", "initials": "C"}, {"family": "Jin", "given": "Kunlin", "initials": "K"}, {"family": "Zhao", "given": "Robert Chunhua", "initials": "RC", "orcid": "0000-0002-4609-8424", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d1fca3775f643f9992e48a753ca1a37.json"}}], "type": "journal article", "published": "2021-10-26", "journal": {"title": "Cell Res", "issn": "1748-7838", "issn-l": null}, "abstract": "The infusion of coronavirus disease 2019 (COVID-19) patients with mesenchymal stem cells (MSCs) potentially improves clinical symptoms, but the underlying mechanism remains unclear. We conducted a randomized, single-blind, placebo-controlled (29 patients/group) phase II clinical trial to validate previous findings and explore the potential mechanisms. Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay (P = 0.0198) and less time required for symptoms remission (P = 0.0194) than those who received placebo. Based on chest images, both severe and critical patients treated with MSCs showed improvement by day 7 (P = 0.0099) and day 21 (P = 0.0084). MSC-treated patients had fewer adverse events. MSC infusion reduced the levels of C-reactive protein, proinflammatory cytokines, and neutrophil extracellular traps (NETs) and promoted the maintenance of SARS-CoV-2-specific antibodies. To explore how MSCs modulate the immune system, we employed single-cell RNA sequencing analysis on peripheral blood. Our analysis identified a novel subpopulation of VNN2+ hematopoietic stem/progenitor-like (HSPC-like) cells expressing CSF3R and PTPRE that were mobilized following MSC infusion. Genes encoding chemotaxis factors - CX3CR1 and L-selectin - were upregulated in various immune cells. MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro. In addition, an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling. Together, our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis.", "doi": "10.1038/s41422-021-00573-y", "pmid": "34702946", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41422-021-00573-y"}, {"db": "pmc", "key": "PMC8546390"}], "notes": [], "created": "2021-11-01T19:40:40.141Z", "modified": "2021-11-01T19:40:40.407Z"}, {"entity": "publication", "iuid": "c91b5940918046b7b7baf2c3432e336b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c91b5940918046b7b7baf2c3432e336b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c91b5940918046b7b7baf2c3432e336b"}}, "title": "Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort", "authors": [{"family": "Carapito", "given": "Raphael", "initials": "R"}, {"family": "Li", "given": "Richard", "initials": "R"}, {"family": "Helms", "given": "Julie", "initials": "J"}, {"family": "Carapito", "given": "Christine", "initials": "C"}, {"family": "Gujja", "given": "Sharvari", "initials": "S"}, {"family": "Rolli", "given": "V\u00e9ronique", "initials": "V"}, {"family": "Guimaraes", "given": "Raony", "initials": "R"}, {"family": "Malagon-Lopez", "given": "Jose", "initials": "J"}, {"family": "Spinnhirny", "given": "Perrine", "initials": "P"}, {"family": "Lederle", "given": "Alexandre", "initials": "A"}, {"family": "Mohseninia", "given": "Razieh", "initials": "R"}, {"family": "Hirschler", "given": "Aur\u00e9lie", "initials": "A"}, {"family": "Muller", "given": "Leslie", "initials": "L"}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Gervais", "given": "Adrian", "initials": "A"}, {"family": "Zhang", "given": "Qian", "initials": "Q"}, {"family": "Danion", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Ruch", "given": "Yvon", "initials": "Y"}, {"family": "Schenck", "given": "Maleka", "initials": "M"}, {"family": "Collange", "given": "Olivier", "initials": "O"}, {"family": "Chamaraux-Tran", "given": "Thi\u00ean Nga", "initials": "TN"}, {"family": "Molitor", "given": "Anne", "initials": "A"}, {"family": "Pichot", "given": "Ang\u00e9lique", "initials": "A"}, {"family": "Bernard", "given": "Alice", "initials": "A"}, {"family": "Tahar", "given": "Ouria", "initials": "O"}, {"family": "Bibi-Triki", "given": "Sabrina", "initials": "S"}, {"family": "Wu", "given": "Haiguo", "initials": "H"}, {"family": "Paul", "given": "Nicod\u00e8me", "initials": "N"}, {"family": "Mayeur", "given": "Sylvain", "initials": "S"}, {"family": "Larnicol", "given": "Annabel", "initials": "A"}, {"family": "Laumond", "given": "G\u00e9raldine", "initials": "G"}, {"family": "Frappier", "given": "Julia", "initials": "J"}, {"family": "Schmidt", "given": "Sylvie", "initials": "S"}, {"family": "Hanauer", "given": "Antoine", "initials": "A"}, {"family": "Macquin", "given": "C\u00e9cile", "initials": "C"}, {"family": "Stemmelen", "given": "Tristan", "initials": "T"}, {"family": "Simons", "given": "Michael", "initials": "M"}, {"family": "Mariette", "given": "Xavier", "initials": "X"}, {"family": "Hermine", "given": "Olivier", "initials": "O"}, {"family": "Fafi-Kremer", "given": "Samira", "initials": "S"}, {"family": "Goichot", "given": "Bernard", "initials": "B"}, {"family": "Drenou", "given": "Bernard", "initials": "B"}, {"family": "Kuteifan", "given": "Khaldoun", "initials": "K"}, {"family": "Pottecher", "given": "Julien", "initials": "J"}, {"family": "Mertes", "given": "Paul Michel", "initials": "PM"}, {"family": "Kailasan", "given": "Shweta", "initials": "S"}, {"family": "Aman", "given": "M Javad", "initials": "MJ"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Thomas", "given": "Anne", "initials": "A"}, {"family": "Viari", "given": "Alain", "initials": "A"}, {"family": "Sanlaville", "given": "Damien", "initials": "D"}, {"family": "Schneider", "given": "Francis", "initials": "F"}, {"family": "Sibilia", "given": "Jean", "initials": "J"}, {"family": "Tharaux", "given": "Pierre Louis", "initials": "PL"}, {"family": "Casanova", "given": "Jean Laurent", "initials": "JL"}, {"family": "Hansmann", "given": "Yves", "initials": "Y"}, {"family": "Lidar", "given": "Daniel", "initials": "D"}, {"family": "Radosavljevic", "given": "Mirjana", "initials": "M"}, {"family": "Gulcher", "given": "Jeffrey R", "initials": "JR"}, {"family": "Meziani", "given": "Ferhat", "initials": "F"}, {"family": "Moog", "given": "Christiane", "initials": "C"}, {"family": "Chittenden", "given": "Thomas W", "initials": "TW"}, {"family": "Bahram", "given": "Seiamak", "initials": "S"}], "type": "journal-article", "published": "2021-10-26", "journal": {"title": "Sci. Transl. Med.", "issn": "1946-6234", "pages": "eabj7521", "issn-l": null}, "abstract": "[Figure: see text].", "doi": "10.1126/scitranslmed.abj7521", "pmid": "34698500", "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "GEO", "key": "GSE172114", "description": "RNA-seq datasets"}, {"db": "URL", "key": "http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD025265", "description": "Proteomics data are available in the ProteomeXchange Consortium database (identifier PXD025265)"}, {"db": "URL", "key": "https://zenodo.org/record/5557611#.YZZcmC8w3OQ", "description": "Codes used for analysis"}], "notes": [], "created": "2021-10-26T18:35:08.060Z", "modified": "2021-11-18T16:24:43.998Z"}, {"entity": "publication", "iuid": "fa8cdbf2d54240edb509d2e0799d6ae8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa8cdbf2d54240edb509d2e0799d6ae8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa8cdbf2d54240edb509d2e0799d6ae8"}}, "title": "GRAd-COV2, a gorilla adenovirus-based candidate vaccine against COVID-19, is safe and immunogenic in younger and older adults", "authors": [{"family": "Lanini", "given": "Simone", "initials": "S"}, {"family": "Capone", "given": "Stefania", "initials": "S"}, {"family": "Antinori", "given": "Andrea", "initials": "A"}, {"family": "Milleri", "given": "Stefano", "initials": "S"}, {"family": "Nicastri", "given": "Emanuele", "initials": "E"}, {"family": "Camerini", "given": "Roberto", "initials": "R"}, {"family": "Agrati", "given": "Chiara", "initials": "C"}, {"family": "Castilletti", "given": "Concetta", "initials": "C"}, {"family": "Mori", "given": "Federica", "initials": "F"}, {"family": "Sacchi", "given": "Alessandra", "initials": "A"}, {"family": "Matusali", "given": "Giulia", "initials": "G"}, {"family": "Gagliardini", "given": "Roberta", "initials": "R"}, {"family": "Ammendola", "given": "Virginia", "initials": "V"}, {"family": "Cimini", "given": "Eleonora", "initials": "E"}, {"family": "Grazioli", "given": "Fabiana", "initials": "F"}, {"family": "Scorzolini", "given": "Laura", "initials": "L"}, {"family": "Napolitano", "given": "Federico", "initials": "F"}, {"family": "Plazzi", "given": "Maria M", "initials": "MM"}, {"family": "Soriani", "given": "Marco", "initials": "M"}, {"family": "De Luca", "given": "Aldo", "initials": "A"}, {"family": "Battella", "given": "Simone", "initials": "S"}, {"family": "Sommella", "given": "Andrea", "initials": "A"}, {"family": "Contino", "given": "Alessandra M", "initials": "AM"}, {"family": "Barra", "given": "Federica", "initials": "F"}, {"family": "Gentile", "given": "Michela", "initials": "M"}, {"family": "Raggioli", "given": "Angelo", "initials": "A"}, {"family": "Shi", "given": "Yufang", "initials": "Y"}, {"family": "Girardi", "given": "Enrico", "initials": "E"}, {"family": "Maeurer", "given": "Markus", "initials": "M"}, {"family": "Capobianchi", "given": "Maria R", "initials": "MR"}, {"family": "Vaia", "given": "Francesco", "initials": "F"}, {"family": "Piacentini", "given": "Mauro", "initials": "M"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}, {"family": "Vitelli", "given": "Alessandra", "initials": "A"}, {"family": "Colloca", "given": "Stefano", "initials": "S"}, {"family": "Folgori", "given": "Antonella", "initials": "A"}, {"family": "Ippolito", "given": "Giuseppe", "initials": "G"}, {"family": "Ottou", "given": "Sandrine", "initials": "S"}, {"family": "Vita", "given": "Serena", "initials": "S"}, {"family": "Vergori", "given": "Alessandra", "initials": "A"}, {"family": "D\u2019Abramo", "given": "Alessandra", "initials": "A"}, {"family": "Petrecchia", "given": "Antonella", "initials": "A"}, {"family": "Montaldo", "given": "Chiara", "initials": "C"}, {"family": "Scalise", "given": "Emilio", "initials": "E"}, {"family": "Grassi", "given": "Germana", "initials": "G"}, {"family": "Casetti", "given": "Rita", "initials": "R"}, {"family": "Bordoni", "given": "Veronica", "initials": "V"}, {"family": "Notari", "given": "Stefania", "initials": "S"}, {"family": "Colavita", "given": "Francesca", "initials": "F"}, {"family": "Meschi", "given": "Silvia", "initials": "S"}, {"family": "Lapa", "given": "Daniele", "initials": "D"}, {"family": "Bordi", "given": "Licia", "initials": "L"}, {"family": "Murachelli", "given": "Silvia", "initials": "S"}, {"family": "Tambasco", "given": "Teresa", "initials": "T"}, {"family": "Grillo", "given": "Alessandra", "initials": "A"}, {"family": "Masone", "given": "Erminia", "initials": "E"}, {"family": "Marchioni", "given": "Elisa", "initials": "E"}, {"family": "Bardhi", "given": "Dorian", "initials": "D"}, {"family": "Porzio", "given": "Ottavia", "initials": "O"}, {"family": "Cocca", "given": "Francesca", "initials": "F"}, {"family": "Murachelli", "given": "Silvia", "initials": "S"}, {"family": "Turrini", "given": "Irene", "initials": "I"}, {"family": "Malescio", "given": "Feliciana", "initials": "F"}, {"family": "Ziviani", "given": "Luigi", "initials": "L"}, {"family": "Lawlor", "given": "Rita", "initials": "R"}, {"family": "Poli", "given": "Federica", "initials": "F"}, {"family": "Martire", "given": "Federica", "initials": "F"}, {"family": "Zamboni", "given": "Daniela", "initials": "D"}, {"family": "Mazzaferri", "given": "Flavia", "initials": "F"}], "type": "journal-article", "published": "2021-10-26", "journal": {"title": "Sci. Transl. Med.", "issn": "1946-6234", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1126/scitranslmed.abj1996", "pmid": "34698501", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:36:34.474Z", "modified": "2021-11-29T06:07:56.622Z"}, {"entity": "publication", "iuid": "c918a56ef26044f7af5082f1360adfd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c918a56ef26044f7af5082f1360adfd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c918a56ef26044f7af5082f1360adfd0"}}, "title": "A more frequent disease monitorering but no increased disease activity in patients with inflammatory bowel disease during the first year of the SARS-CoV-2 pandemic. A retrospective study.", "authors": [{"family": "Lindhagen", "given": "Sara", "initials": "S"}, {"family": "Karling", "given": "Pontus", "initials": "P", "orcid": "0000-0002-5607-0118", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e40faefd22e41449b1a7d717efead99.json"}}], "type": "journal article", "published": "2021-10-26", "journal": {"title": "Scand J Gastroenterol", "issn": "1502-7708", "pages": "1-6", "issn-l": null}, "abstract": "The SARS-CoV-2 pandemic abruptly switched the healthcare service for patients with inflammatory bowel disease (IBD) towards a telemedicine dominated approach. The aim of this study was to investigate the impact of this switch on monitoring of patients and on disease activity.\n\nThe pre-pandemic year included 868 patients and the first year of the pandemic included 891 patients. Medical records were retrospectively checked for contacts, changes in medical treatment, performed fecal calprotectin (FC) tests and colonoscopies.\n\nThe scheduled follow-up visits to a doctor for patients with IBD shifted from mostly face-to-face pre-pandemic (from 389 to 118 appointments) to mostly telephone-based during the pandemic (from 13 to 423 appointments). There was a 21.3% increase in mean overall scheduled health contacts (p < .001) and a 20.0% increase for the mean number of FC tests (p < .001) in the year of the pandemic compared to the pre-pandemic year. The proportion of patients who had a surveillance colonoscopy was significant lower in the year of the pandemic compared to the pre-pandemic year (12.7% vs 20.1%; p = .002). There were no difference in the proportion of patients with a median FC > 200 mg/kg (18.2% vs 17.1%; p = .767) and in the proportion of patients who changed their medical treatment (24.7% vs 23.9%; p = .713) in the first year of the pandemic compared to the prepandemic year.\n\nThe shift towards a telemedicine oriented IBD healthcare service in the first year of the pandemic significantly increased the scheduled contacts, as well as the frequency of FC testing. However, there was a significant decrease in performed surveillance colonoscopies. Between the two periods observed, the patients showed no difference in medical treatment or in disease activity.", "doi": "10.1080/00365521.2021.1993328", "pmid": "34699290", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-27T05:07:31.917Z", "modified": "2021-10-27T05:07:46.378Z"}, {"entity": "publication", "iuid": "0b8c088789ae4f52b144b57d5b341d3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b8c088789ae4f52b144b57d5b341d3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b8c088789ae4f52b144b57d5b341d3d"}}, "title": "Telemedicine as an alternative way to access abortion in Italy and characteristics of requests during the COVID-19 pandemic", "authors": [{"family": "Brandell", "given": "Karin", "initials": "K", "orcid": "0000-0003-0548-3374", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8948d3105df4faaa867b27a1fb3d4ed.json"}}, {"family": "Vanbenschoten", "given": "Hannah", "initials": "H"}, {"family": "Parachini", "given": "Mirella", "initials": "M"}, {"family": "Gomperts", "given": "Rebecca", "initials": "R"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}], "type": "journal-article", "published": "2021-10-25", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-1991", "pages": "bmjsrh-2021-201281", "issn-l": null}, "abstract": null, "doi": "10.1136/bmjsrh-2021-201281", "pmid": null, "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:32:18.606Z", "modified": "2021-10-26T18:32:18.674Z"}, {"entity": "publication", "iuid": "66ddd8c7d6ab449e9cfff0cbc669e25b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66ddd8c7d6ab449e9cfff0cbc669e25b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66ddd8c7d6ab449e9cfff0cbc669e25b"}}, "title": "Synchronization in epidemic growth and the impossibility of selective containment.", "authors": [{"family": "Budich", "given": "Jan C", "initials": "JC"}, {"family": "Bergholtz", "given": "Emil J", "initials": "EJ"}], "type": "journal article", "published": "2021-10-25", "journal": {"title": "Math Med Biol", "issn": "1477-8602", "issn-l": null}, "abstract": "Containment, aiming to prevent the epidemic stage of community-spreading altogether, and mitigation, aiming to merely 'flatten the curve' of a wide-ranged outbreak, constitute two qualitatively different approaches to combating an epidemic through non-pharmaceutical interventions. Here, we study a simple model of epidemic dynamics separating the population into two groups, namely a low-risk group and a high-risk group, for which different strategies are pursued. Due to synchronization effects, we find that maintaining a slower epidemic growth behaviour for the high-risk group is unstable against any finite coupling between the two groups. More precisely, the density of infected individuals in the two groups qualitatively evolves very similarly, apart from a small time delay and an overall scaling factor quantifying the coupling between the groups. Hence, selective containment of the epidemic in a targeted (high-risk) group is practically impossible whenever the surrounding society implements a mitigated community-spreading. We relate our general findings to the ongoing COVID-19 pandemic.", "doi": "10.1093/imammb/dqab013", "pmid": "34695187", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6409757"}], "notes": [], "created": "2021-10-26T18:28:24.487Z", "modified": "2021-10-26T18:28:24.523Z"}, {"entity": "publication", "iuid": "0f3f009975074859a7e934f2272ba059", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0f3f009975074859a7e934f2272ba059.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0f3f009975074859a7e934f2272ba059"}}, "title": "Deviant Swedes in the Global Covid-19 Media Environment", "authors": [{"family": "Irwin", "given": "Rachel E", "initials": "RE"}], "type": "journal-article", "published": "2021-10-25", "journal": {"title": "Medical Anthropology", "issn": "0145-9740", "pages": "1-15", "issn-l": null}, "abstract": null, "doi": "10.1080/01459740.2021.1988594", "pmid": null, "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:32:03.030Z", "modified": "2021-10-26T18:32:03.067Z"}, {"entity": "publication", "iuid": "2664b49079004ce3ab5f1bbf0f59e1df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2664b49079004ce3ab5f1bbf0f59e1df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2664b49079004ce3ab5f1bbf0f59e1df"}}, "title": "Consequences of the Covid-19 virus on individuals receiving homecare services in Norway. A qualitative study of nursing students' reflective notes.", "authors": [{"family": "Eide", "given": "Leslie S P", "initials": "LSP"}, {"family": "Giske", "given": "Tove", "initials": "T"}, {"family": "Kuven", "given": "Britt Moene", "initials": "BM"}, {"family": "Johansson", "given": "Linda", "initials": "L"}], "type": "journal article", "published": "2021-10-25", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "issn-l": null, "volume": "20", "issue": "1", "pages": "208"}, "abstract": "Reflective notes in nursing education can facilitate students' understanding of how individuals in need of home healthcare services experience unfamiliar situations, such as a pandemic. The aim of this study is to describe the consequences of the COVID-19 virus for individuals receiving homecare services through the eyes of nursing students.\r\n\r\nThis is a qualitative descriptive study using content analysis to examine reflection notes from 17 nursing students in their last year of academic studies while undertaking home healthcare service training.\r\n\r\nOur study shows students' reflections on the consequences of the COVID-19 virus on individuals needing home healthcare services and their families. The analysis reveals three categories that described the effect of the virus according to students' reflections: i) how social life became restricted and only includes the closest family members and home healthcare staff (declining social circle), ii) how family members take on more responsibility to care for the individual and the pronounced impact of this on the day-to-day lives of the individual's next of kin (expanding responsibility of care), and iii) actions and reactions related to preventing the spread of the virus (dealing with the invisible threat).\r\n\r\nStudents' reflection notes show that COVID-19 had major consequences, not only on the individuals receiving home healthcare services, but also on their relatives and on home healthcare staff.", "doi": "10.1186/s12912-021-00732-x", "pmid": "34689756", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12912-021-00732-x"}], "notes": [], "created": "2021-10-26T18:20:20.104Z", "modified": "2022-02-17T12:19:36.937Z"}, {"entity": "publication", "iuid": "c47d5d1ccea24687a1359fc194361747", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c47d5d1ccea24687a1359fc194361747.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c47d5d1ccea24687a1359fc194361747"}}, "title": "Factors related to preventive COVID-19 behaviors using health belief model among general population: a cross-sectional study in Iran.", "authors": [{"family": "Karimy", "given": "Mahmood", "initials": "M"}, {"family": "Bastami", "given": "Fatemeh", "initials": "F"}, {"family": "Sharifat", "given": "Robab", "initials": "R"}, {"family": "Heydarabadi", "given": "Akbar Babaei", "initials": "AB"}, {"family": "Hatamzadeh", "given": "Naser", "initials": "N"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Cheraghian", "given": "Bahman", "initials": "B"}, {"family": "Zamani-Alavijeh", "given": "Fereshteh", "initials": "F"}, {"family": "Jasemzadeh", "given": "Mehrnoosh", "initials": "M"}, {"family": "Araban", "given": "Marzieh", "initials": "M", "orcid": "0000-0001-9920-0261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/267b131c24034c33b0ddff1b97f316a5.json"}}], "type": "journal article", "published": "2021-10-24", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "21", "issue": "1", "pages": "1934", "issn-l": null}, "abstract": "Coronavirus disease (COVID-19) pandemic has become one of the biggest challenges to global health and economy. The present study aimed to explore the factors related to preventive health behaviors during the COVID-19 pandemic in Khuzestan Province, South of Iran, using the Health Belief Model (HBM).\n\nThe present cross-sectional study was conducted in the period between July 2020 and September 2020. A total of 1090 people from Khuzestan province participated in the study. The data collection method included a multistage cluster sampling method with a random selection of provincial of health centers. The questionnaire collected socio-demographic information and HBM constructs (e.g., perceived susceptibility, perceived severity, perceived benefits and barriers, cues to action, and COVID-19 preventive behaviors). Data were analyzed using ANOVA, t-test, hierarchical multiple linear regression, and SPSS version 22.\n\nThe mean age of the participants was 35.53 \u00b1 11.53, more than half of them were female (61.6%) and married (65.3). The results showed that 27% of the variance in the COVID-19 preventive behaviors was explained by HBM constructs. The regression analysis indicated that female gender (\u03b2 = 0.11), perceived benefits (\u03b2 = 0.10), perceived barriers (\u03b2 = - 0.18), external cues to action (\u03b2 = 0.25), and internal cues to action (\u03b2 = 0.12) were significantly associated with COVID-19 preventive behaviors (p < 0.05).\n\nDesigning an educational intervention on the basis of HBM might be considered as a framework for the correction of beliefs and adherence to COVID-19 behavior. Health information campaigns need to (1) emphasize the benefits of preventive behaviors including avoiding the likelihood of getting a chronic disease and complications of the disease, (2) highlight the tips and advice to overcome the barriers (3) provide cues to action by means of showing various reminders in social media (4) focusing on adoption of COVID-19-related preventive behaviors, especially among men.", "doi": "10.1186/s12889-021-11983-3", "pmid": "34689728", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11983-3"}], "notes": [], "created": "2021-10-26T18:19:52.461Z", "modified": "2021-10-26T18:20:04.121Z"}, {"entity": "publication", "iuid": "753088ac0907438a849b4b5a119ed2cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/753088ac0907438a849b4b5a119ed2cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/753088ac0907438a849b4b5a119ed2cb"}}, "title": "X-Linked TLR7 Deficiency Underlies Critical COVID-19 Pneumonia in a Male Patient with Ataxia-Telangiectasia.", "authors": [{"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Vosughimotlagh", "given": "Ahmad", "initials": "A"}, {"family": "Asano", "given": "Takaki", "initials": "T"}, {"family": "Landegren", "given": "Nils", "initials": "N"}, {"family": "Boisson", "given": "Bertrand", "initials": "B"}, {"family": "Delavari", "given": "Samaneh", "initials": "S"}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Aranda-Guill\u00e9n", "given": "Maribel", "initials": "M"}, {"family": "Wang", "given": "Yating", "initials": "Y"}, {"family": "Zuo", "given": "Fanglei", "initials": "F"}, {"family": "Sardh", "given": "Fabian", "initials": "F"}, {"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Zhang", "given": "Qian", "initials": "Q"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q", "orcid": "0000-0003-1990-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94a32366862b470eba3a15521b9be290.json"}}], "type": "journal article", "published": "2021-10-23", "journal": {"title": "J Clin Immunol", "issn": "1573-2592", "issn-l": "0271-9142"}, "abstract": "Coronavirus disease 2019 (COVID-19) exhibits a wide spectrum of clinical manifestations, ranging from asymptomatic to critical conditions. Understanding the mechanism underlying life-threatening COVID-19 is instrumental for disease prevention and treatment in individuals with a high risk.\n\nWe aimed to identify the genetic cause for critical COVID-19 pneumonia in a patient with a preexisting inborn error of immunity (IEI).\n\nSerum levels of specific antibodies against the virus and autoantibodies against type I interferons (IFNs) were measured. Whole exome sequencing was performed, and the impacts of candidate gene variants were investigated. We also evaluated 247 ataxia-telangiectasia (A-T) patients in the Iranian IEI registry.\n\nWe report a 7-year-old Iranian boy with a preexisting hyper IgM syndrome who developed critical COVID-19 pneumonia. IgM only specific COVID-19 immune response was detected but no autoantibodies against type I IFN were observed. A homozygous deleterious mutation in the ATM gene was identified, which together with his antibody deficiency, radiosensitivity, and neurological signs, established a diagnosis of A-T. Among the 247 A-T patients evaluated, 36 had SARS-CoV-2 infection, but all had mild symptoms or were asymptomatic except the index patient. A hemizygous deleterious mutation in the TLR7 gene was subsequently identified in the patient.\n\nWe report a unique IEI patient with combined ATM and TLR7 deficiencies. The two genetic defects underlie A-T and critical COVID-19 in this patient, respectively.", "doi": "10.1007/s10875-021-01151-y", "pmid": "34686943", "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10875-021-01151-y"}, {"db": "pmc", "key": "PMC8536475"}], "notes": [], "created": "2021-10-26T18:18:29.681Z", "modified": "2021-11-18T15:08:59.029Z"}, {"entity": "publication", "iuid": "13be130c39184985887399e1f4a8c94e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13be130c39184985887399e1f4a8c94e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13be130c39184985887399e1f4a8c94e"}}, "title": "Potential therapeutic effect of oxygen-ozone in controlling of COVID-19 disease.", "authors": [{"family": "Yousefi", "given": "Bahman", "initials": "B"}, {"family": "Banihashemian", "given": "Seyedeh Zahra", "initials": "SZ"}, {"family": "Feyzabadi", "given": "Zahra Khatibiyan", "initials": "ZK"}, {"family": "Hasanpour", "given": "Sahar", "initials": "S"}, {"family": "Kokhaei", "given": "Parviz", "initials": "P"}, {"family": "Abdolshahi", "given": "Anna", "initials": "A"}, {"family": "Emadi", "given": "Alireza", "initials": "A"}, {"family": "Eslami", "given": "Majid", "initials": "M"}], "type": "journal article", "published": "2021-10-23", "journal": {"title": "Med Gas Res", "issn": "2045-9912", "volume": "12", "issue": "2", "pages": "33-40", "issn-l": null}, "abstract": "Atmospheric ozone is produced when nitrogen oxides react with volatile organic compounds. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome contains a unique N-terminal fragment in the Spike protein, which allows it to bind to air pollutants in the environment. 'Our approach in this review is to study ozone and its effect on the SARS-CoV-2 virus and patients with coronavirus disease 2019 (COVID-19). Article data were collected from PubMed, Scopus, and Google Scholar databases. Ozone therapy has antiviral properties, improves blood flow, facilitates the transfer of oxygen in hypoxemic tissues, and reduces blood coagulation phenomena in COVID-19 patients. Ozone has immunomodulatory effects by modulating cytokines (reduction of interleukin-1, interleukin-6, tumor necrosis factor-\u03b1, and interleukin-10), induction of interferon-\u03b3, anti-inflammatory properties by modulating NOD-, LRR- and pyrin domain-containing protein 3, inhibition of cytokine storm (blocking nuclear factor-\u03baB and stimulating nuclear factor erythroid 2-related factor 2 pathway), stimulates cellular/humoral immunity/phagocytic function and blocks angiotensin-converting enzyme 2. In direct oxygen-ozone injection, oxygen reacts with several biological molecules such as thiol groups in albumin to form ozonoids. Intravenous injection of ozonated saline significantly increases the length of time a person can remain hypoxic. The rectal ozone protocol is rectal ozone insufflation, resulting in clinical improvement in oxygen saturation and biochemical improvement (fibrinogen, D-dimer, urea, ferritin, LDH, interleukin-6, and C-reactive protein). In general, many studies have shown the positive effect of ozone therapy as a complementary therapy in the recovery of COVID-19 patients. All the findings indicate that systemic ozone therapy is nontoxic and has no side effects in these patients.", "doi": "10.4103/2045-9912.325989", "pmid": "34677149", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "MedGasRes_2022_12_2_33_325989"}], "notes": [], "created": "2021-10-26T18:13:10.520Z", "modified": "2021-10-26T18:13:10.562Z"}, {"entity": "publication", "iuid": "309ad45ec547436298caa7a3df2df00d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/309ad45ec547436298caa7a3df2df00d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/309ad45ec547436298caa7a3df2df00d"}}, "title": "Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19.", "authors": [{"family": "Schulthei\u00df", "given": "Christoph", "initials": "C"}, {"family": "Paschold", "given": "Lisa", "initials": "L"}, {"family": "Willscher", "given": "Edith", "initials": "E"}, {"family": "Simnica", "given": "Donjete", "initials": "D"}, {"family": "W\u00f6stemeier", "given": "Anna", "initials": "A"}, {"family": "Muscate", "given": "Franziska", "initials": "F"}, {"family": "Wass", "given": "Maxi", "initials": "M"}, {"family": "Eisenmann", "given": "Stephan", "initials": "S"}, {"family": "Dutzmann", "given": "Jochen", "initials": "J"}, {"family": "Key\u00dfer", "given": "Gernot", "initials": "G"}, {"family": "Gagliani", "given": "Nicola", "initials": "N"}, {"family": "Binder", "given": "Mascha", "initials": "M"}], "type": "journal article", "published": "2021-10-23", "journal": {"title": "iScience", "issn": "2589-0042", "pages": "103325", "issn-l": "2589-0042"}, "abstract": "In parasite and viral infections, aberrant B cell responses can suppress germinal center reactions thereby blunting long-lived memory and may provoke immunopathology including autoimmunity. Using COVID-19 as model, we set out to identify serological, cellular and transcriptomic imprints of pathological responses linked to autoreactive B cells at single-cell resolution. We show that excessive plasmablast expansions are prognostically adverse, correlate with auto-antibody production, but do not hinder the formation of neutralizing antibodies. While plasmablasts followed IL-4 and BAFF driven developmental trajectories, were polyclonal and not enriched in autoreactive B cells, we identified two memory populations (CD80+/ISG15+ and CD11c+/SOX5+/T-bet+/-) with immunogenetic and transcriptional signs of autoreactivity that may be the cellular source of auto-antibodies in COVID-19 and that may persist beyond recovery. Immunomodulatory interventions discouraging such adverse responses may be useful in selected patients to shift the balance from autoreactivity towards long-term memory.", "doi": "10.1016/j.isci.2021.103325", "pmid": "34723157", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(21)01294-3"}, {"db": "pmc", "key": "PMC8536484"}], "notes": [], "created": "2021-11-02T15:32:21.332Z", "modified": "2021-11-02T15:32:55.847Z"}, {"entity": "publication", "iuid": "38187affa925475985a1875afa76de7b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38187affa925475985a1875afa76de7b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38187affa925475985a1875afa76de7b"}}, "title": "Family Function and Child Adjustment Difficulties in the COVID-19 Pandemic: An International Study.", "authors": [{"family": "Foley", "given": "Sarah", "initials": "S"}, {"family": "Badinlou", "given": "Farzaneh", "initials": "F"}, {"family": "Brocki", "given": "Karin C", "initials": "KC"}, {"family": "Frick", "given": "Matilda A", "initials": "MA"}, {"family": "Ronchi", "given": "Luca", "initials": "L", "orcid": "0000-0001-7723-9376", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1e89c62c76f443288c1df82f370cdf4.json"}}, {"family": "Hughes", "given": "Claire", "initials": "C"}], "type": "journal article", "published": "2021-10-23", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "21", "issn-l": null}, "abstract": "To estimate specific proximal and distal effects of COVID-19-related restrictions on families on children's adjustment problems, we conducted a six-site international study. In total, 2516 parents from Australia, China, Italy, Sweden, the United Kingdom, and the United States of America living with a young child (M = 5.77, ageSD = 1.10, range = 3 to 8 years, 47.9% female) completed an online survey between April and July 2020. The survey included the Strengths and Difficulties Questionnaire and family risk factors (parent distress, parent-child conflict, couple conflict, and household chaos) as well as a scale to index COVID-19-related family disruption. Our analyses also included public data on the stringency of national restrictions. Across the six sites, parental responses indicated elevated levels of hyperactivity, conduct, and emotion problems in children from families characterized by heightened levels of parent distress, parent-child conflict, and household chaos. In contrast, increased peer problems were more strongly related to COVID-19-related social disruption and stringency measures. Mediation models demonstrated that associations between COVID-19 social disruption and child difficulties could be explained by parental distress. Taken together, these results suggest that although the experience of the pandemic differed across countries, associations between COVID-19-related family experiences and child adjustment difficulties were similar in their nature and magnitude across six different contexts. Programs to support family resilience could help buffer the impact of the pandemic for two generations.", "doi": "10.3390/ijerph182111136", "pmid": "34769654", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph182111136"}, {"db": "pmc", "key": "PMC8582895"}], "notes": [], "created": "2021-11-26T15:10:11.167Z", "modified": "2021-11-26T15:10:11.226Z"}, {"entity": "publication", "iuid": "38d1fc5ab22a4d00aedc4f1700140bdf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38d1fc5ab22a4d00aedc4f1700140bdf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38d1fc5ab22a4d00aedc4f1700140bdf"}}, "title": "Use of Quantitative Dried Blood Spots to Evaluate the Post-Vaccination Level of Neutralizing Antibodies against SARS-CoV-2.", "authors": [{"family": "Marchand", "given": "Alexandre", "initials": "A", "orcid": "0000-0002-2670-6939", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19b0f52f01ef473d91392b151603c1c3.json"}}, {"family": "Roulland", "given": "Ingrid", "initials": "I"}, {"family": "Semence", "given": "Florian", "initials": "F", "orcid": "0000-0002-2313-9246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2fef84471334fb8b8688905d5426487.json"}}, {"family": "Beck", "given": "Olof", "initials": "O"}, {"family": "Ericsson", "given": "Magnus", "initials": "M", "orcid": "0000-0002-4123-3084", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72e1b083138945508edb8121d47826e3.json"}}], "type": "journal article", "published": "2021-10-22", "journal": {"title": "Life (Basel)", "issn": "2075-1729", "volume": "11", "issue": "11", "pages": "1125", "issn-l": null}, "abstract": "To combat the COVID-19 pandemic, vaccines against SARS-CoV-2 are now given to protect populations worldwide. The level of neutralizing antibodies following the vaccination will evolve with time and vary between individuals. Immunoassays quantifying immunoglobulins against the viral spike (S) protein in serum/plasma have been developed, but the need for venous blood samples could limit the frequency and scale of control in populations. The use of a quantitative dried blood spot (DBS) that can be self-collected would simplify this monitoring. The objective of this study was to determine whether a quantitative DBS device (Capitainer qDBS 10 \u00b5L) could be used in combination with an Elecsys anti-SARS-CoV-2 S immunoassay from Roche to follow the development and persistence of anti-S antibodies. This objective was carried out through two clinical studies. The first study investigated 14 volunteers who received two doses of the Comirnaty (Pfizer) vaccine. The levels of anti-S antibodies and the progression over time post-vaccination were studied for three months. The level of produced antibodies varied between subjects, but a similar trend was observed. The anti-S antibodies were highly stimulated by the second dose (\u00d7100) and peaked two weeks later. The antibody levels subsequently decreased and three months later were down to 65%. DBS proved to be sufficiently sensitive for use in evaluating the immune status against SARS-CoV-2 over a prolonged time. The second cohort was composed of 200 random patients from a clinical chemistry department in Stockholm. In this cohort, we had no information on previous COVID-19 infections or vaccination. Nevertheless, 87% of the subjects had anti-S immunoglobulins over 0.8 U/mL, and the bias between plasma and DBS proved to be variable, as was also seen in the first vaccination study.", "doi": "10.3390/life11111125", "pmid": "34833001", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8620034"}, {"db": "pii", "key": "life11111125"}], "notes": [], "created": "2021-12-18T18:15:01.656Z", "modified": "2023-06-19T14:20:04.060Z"}, {"entity": "publication", "iuid": "82b7b8a2c81044dd954af8d86a918c8d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82b7b8a2c81044dd954af8d86a918c8d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82b7b8a2c81044dd954af8d86a918c8d"}}, "title": "SARS-CoV-2 specific B- and T-cell immunity in a population-based study of young Swedish adults.", "authors": [{"family": "Bj\u00f6rkander", "given": "Sophia", "initials": "S"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Zuo", "given": "Fanglei", "initials": "F"}, {"family": "Ekstr\u00f6m", "given": "Sandra", "initials": "S"}, {"family": "Wang", "given": "Yating", "initials": "Y"}, {"family": "Wan", "given": "Hui", "initials": "H"}, {"family": "Sherina", "given": "Natalia", "initials": "N"}, {"family": "Schoutens", "given": "Lisanne", "initials": "L"}, {"family": "Andr\u00e9ll", "given": "Juni", "initials": "J"}, {"family": "Andersson", "given": "Niklas", "initials": "N"}, {"family": "Georgelis", "given": "Antonios", "initials": "A"}, {"family": "Bergstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}, {"family": "BAMSE COVID-19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-10-22", "journal": {"title": "J Allergy Clin Immunol", "issn": "1097-6825", "issn-l": "0091-6749"}, "abstract": "Young adults are now considered major spreaders of COVID-19 disease. Although most young individuals suffer from mild to moderate disease, there are concerns of long-term adverse health effects. The impact of COVID-19 disease and to which extent population-level immunity against SARS-CoV-2 exist in young adults remain unclear.\n\nTo conduct a population-based study on humoral and cellular immunity to SARS-CoV-2 and explore COVID-19 disease characteristics in young adults.\n\nWe invited participants from the Swedish BAMSE birth cohort (age 24-27 years) to take part in a COVID-19 follow-up. From 980 participants (October 2020-June 2021), we here present data on SARS-CoV-2 RBD-specific IgM, IgA and IgG titres measured by ELISA and on symptoms and epidemiological factors associated with seropositivity. Further, SARS-CoV-2-specific memory B- and T-cell responses were detected for a subpopulation (n=108) by ELISpot and Fluorospot.\n\n28.4% of subjects were seropositive of which 18.4% were IgM single positive. One in seven seropositive subjects were asymptomatic. Seropositivity associated with use of public transport, but not with sex, asthma, rhinitis, IgE-sensitization, smoking or BMI. In a subset of representative samples, 20.7% and 35.0% had detectable SARS-CoV-2 specific B- and T-cell responses, respectively. B- and T-cell memory responses were clearly associated with seropositivity, but T-cell responses were also detected in 17.2% of seronegative subjects.\n\nAssessment of IgM and T-cell responses may improve population-based estimations of SARS-CoV-2 infection. The pronounced surge of both symptomatic and asymptomatic infections among young adults should imply a continuation of the large-scale vaccination campaign.", "doi": "10.1016/j.jaci.2021.10.014", "pmid": "34695490", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Funder: VR": null, "Funder: H2020": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pii", "key": "S0091-6749(21)01626-2"}], "notes": [], "created": "2021-10-26T18:21:08.827Z", "modified": "2021-10-26T18:23:13.339Z"}, {"entity": "publication", "iuid": "c5eee811036f4f19b853bdb01f8ecbbc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5eee811036f4f19b853bdb01f8ecbbc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5eee811036f4f19b853bdb01f8ecbbc"}}, "title": "Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue.", "authors": [{"family": "Niessl", "given": "Julia", "initials": "J", "orcid": "0000-0001-8852-1924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70aba42c7f0b400eba1a226ee193d9fd.json"}}, {"family": "Sekine", "given": "Takuya", "initials": "T", "orcid": "0000-0001-7649-0593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a234e0d77c145aa8d23b89fde1c5883.json"}}, {"family": "Lange", "given": "Joshua", "initials": "J", "orcid": "0000-0001-6452-0695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1cca3794b2844599b618aa215421d61b.json"}}, {"family": "Konya", "given": "Viktoria", "initials": "V"}, {"family": "Forkel", "given": "Marianne", "initials": "M"}, {"family": "Maric", "given": "Jovana", "initials": "J"}, {"family": "Rao", "given": "Anna", "initials": "A"}, {"family": "Mazzurana", "given": "Luca", "initials": "L"}, {"family": "Kokkinou", "given": "Efthymia", "initials": "E"}, {"family": "Weigel", "given": "Whitney", "initials": "W"}, {"family": "Llewellyn-Lacey", "given": "Sian", "initials": "S", "orcid": "0000-0002-4703-0413", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d3831e832f6b490d9b24d89170e66eaa.json"}}, {"family": "Hodcroft", "given": "Emma B", "initials": "EB", "orcid": "0000-0002-0078-2212", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/563993c9fb68466c8867ca7600733548.json"}}, {"family": "Karlsson", "given": "Annika C", "initials": "AC", "orcid": "0000-0002-2028-8393", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9abf28110888427497db1e4abf6ff71d.json"}}, {"family": "Fehrm", "given": "Johan", "initials": "J", "orcid": "0000-0002-4304-3700", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/948413806ff24d02b4f0016c8e1af6bf.json"}}, {"family": "Sundman", "given": "Joar", "initials": "J", "orcid": "0000-0003-4475-603X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5092a6807ecd460d83fd07790267fac6.json"}}, {"family": "Price", "given": "David A", "initials": "DA", "orcid": "0000-0001-9416-2737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/734b7fd55fca47f8b00d1281331ef39a.json"}}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J", "orcid": "0000-0002-1119-0976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41c258d321084e909f0c9a6ff8693533.json"}}, {"family": "Friberg", "given": "Danielle", "initials": "D", "orcid": "0000-0001-8327-1292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7003e0514ab84574b19ac36dff3f8825.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}], "type": "journal article", "published": "2021-10-22", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "issn-l": "2470-9468", "volume": "6", "issue": "64", "pages": "eabk0894"}, "abstract": "Cross-reactive CD4+ T cells that recognize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more commonly detected in the peripheral blood of unexposed individuals compared with SARS-CoV-2\u2013reactive CD8+ T cells. However, large numbers of memory CD8+ T cells reside in tissues, feasibly harboring localized SARS-CoV-2\u2013specific immune responses. To test this idea, we performed a comprehensive functional and phenotypic analysis of virus-specific T cells in tonsils, a major lymphoid tissue site in the upper respiratory tract, and matched peripheral blood samples obtained from children and adults before the emergence of COVID-19 (coronavirus disease 2019). We found that SARS-CoV-2\u2013specific memory CD4+ T cells could be found at similar frequencies in the tonsils and peripheral blood in unexposed individuals, whereas functional SARS-CoV-2\u2013specific memory CD8+ T cells were almost only detectable in the tonsils. Tonsillar SARS-CoV-2\u2013specific memory CD8+ T cells displayed a follicular homing and tissue-resident memory phenotype, similar to tonsillar Epstein-Barr virus\u2013specific memory CD8+ T cells, but were functionally less potent than other virus-specific memory CD8+ T cell responses. The presence of preexisting tissue-resident memory CD8+ T cells in unexposed individuals could potentially enable rapid sentinel immune responses against SARS-CoV-2.", "doi": "10.1126/sciimmunol.abk0894", "pmid": "34519539", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: VR": null}, "xrefs": [], "notes": [], "created": "2021-09-20T06:25:17.561Z", "modified": "2023-06-19T14:47:48.944Z"}, {"entity": "publication", "iuid": "691b17ed7dd44d05923a3ddeca351561", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/691b17ed7dd44d05923a3ddeca351561.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/691b17ed7dd44d05923a3ddeca351561"}}, "title": "Epidemic versus economic performances of the COVID-19 lockdown in Japan: A Mobility Data Analysis.", "authors": [{"family": "Zhang", "given": "Haoran", "initials": "H"}, {"family": "Li", "given": "Peiran", "initials": "P"}, {"family": "Zhang", "given": "Zhiwen", "initials": "Z"}, {"family": "Li", "given": "Wenjing", "initials": "W"}, {"family": "Chen", "given": "Jinyu", "initials": "J"}, {"family": "Song", "given": "Xuan", "initials": "X"}, {"family": "Shibasaki", "given": "Ryosuke", "initials": "R"}, {"family": "Yan", "given": "Jinyue", "initials": "J"}], "type": "journal article", "published": "2021-10-22", "journal": {"title": "Cities", "issn": "0264-2751", "issn-l": null, "volume": null, "issue": null, "pages": "103502"}, "abstract": "Lockdown measures have been a \"panacea\" for pandemic control but also a violent \"poison\" for economies. Lockdown policies strongly restrict human mobility but mobility reduce does harm to economics. Governments meet a thorny problem in balancing the pros and cons of lockdown policies, but lack comprehensive and quantified guides. Based on millions of financial transaction records, and billions of mobility data, we tracked spatio-temporal business networks and human daily mobility, then proposed a high-resolution two-sided framework to assess the epidemiological performance and economic damage of different lockdown policies. We found that the pandemic duration under the strictest lockdown is less about two months than that under the lightest lockdown, which makes the strictest lockdown characterize both epidemiologically and economically efficient. Moreover, based on the two-sided model, we explored the spatial lockdown strategy. We argue that cutting off intercity commuting is significant in both epidemiological and economical aspects, and finally helped governments figure out the Pareto optimal solution set of lockdown strategy.", "doi": "10.1016/j.cities.2021.103502", "pmid": "34703071", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0264-2751(21)00401-7"}, {"db": "pmc", "key": "PMC8531026"}], "notes": [], "created": "2021-11-01T19:41:11.603Z", "modified": "2021-11-01T19:41:41.272Z"}, {"entity": "publication", "iuid": "dacbc120d6864970a1e0bad1a9fb510e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dacbc120d6864970a1e0bad1a9fb510e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dacbc120d6864970a1e0bad1a9fb510e"}}, "title": "Clozapine treatment and risk of severe COVID-19 infection.", "authors": [{"family": "Ohlis", "given": "Anna", "initials": "A", "orcid": "0000-0001-9046-5773", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59faf1045fa242d28c4044315d0181d2.json"}}, {"family": "S\u00f6rberg Wallin", "given": "Alma", "initials": "A", "orcid": "0000-0002-8804-095X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bdaa3ba8e9c149a6b4c05d924f31d0e5.json"}}, {"family": "Sarafis", "given": "Anna", "initials": "A"}, {"family": "Sj\u00f6qvist", "given": "Hugo", "initials": "H"}, {"family": "MacCabe", "given": "James H", "initials": "JH", "orcid": "0000-0002-6754-1018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10525437e48b4917bcea4011f1db2d66.json"}}, {"family": "Ahlen", "given": "Johan", "initials": "J", "orcid": "0000-0003-1415-2200", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0bb3ddc3a2e0432585cf06c038554088.json"}}, {"family": "Dalman", "given": "Christina", "initials": "C"}], "type": "journal article", "published": "2021-10-22", "journal": {"title": "Acta Psychiatr Scand", "issn": "1600-0447", "issn-l": null}, "abstract": "To investigate whether patients with clozapine treatment are at an increased risk of a more severe COVID-19 infection as compared with patients on other antipsychotic drugs.\n\nIn this register-based cohort study, all residents (age 18 or older) in the Stockholm Region with a psychotic disorder diagnosis and antipsychotic treatment were included (N = 8 233) and followed from March 1, 2020 to January 14, 2021. The exposure was defined as clozapine treatment and the outcome measures (indicating a more severe COVID-19 infection) were: inpatient care, care within intensive care unit or death due to COVID-19 infection. Differences in outcome rates between exposed (n = 966) and unexposed (other antipsychotics; n = 7 267) were examined using Cox proportional hazards models and expressed as hazard ratios (HR) with 95% confidence intervals (CI).\n\nNo statistically significant differences in outcome rates were found between the two groups of patients after adjusting for age, sex, and residence in retirement homes. The adjusted HR for the exposed compared to the unexposed was 0.96 (95% CI: 0.54, 1.70) for inpatient care; 1.69 (0.48, 5.93) for care in intensive care unit (ICU); and 0.86 (0.26, 2.80) for death. Regarding inpatient care, additional adjusting for country of birth, living in socioeconomically vulnerable areas, number of care visits during the previous year, and comorbid medical illnesses did not alter the results.\n\nOur results may add support to the present guidelines, recommending sustained clozapine treatment during the current COVID-19 pandemic with careful monitoring and readiness to alter drug doses as needed.", "doi": "10.1111/acps.13379", "pmid": "34676888", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:12:37.225Z", "modified": "2021-10-26T18:12:50.320Z"}, {"entity": "publication", "iuid": "c298ed13cf994b5d98401e37cd050838", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c298ed13cf994b5d98401e37cd050838.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c298ed13cf994b5d98401e37cd050838"}}, "title": "Recurrent sick leave after COVID-19: investigating the first wave of the pandemic in a comprehensive Swedish registry-based study.", "authors": [{"family": "Palstam", "given": "Annie", "initials": "A"}, {"family": "Westerlind", "given": "Emma", "initials": "E"}, {"family": "Sunnerhagen", "given": "Katharina S", "initials": "KS"}, {"family": "Persson", "given": "Hanna C", "initials": "HC"}], "type": "journal article", "published": "2021-10-21", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "1914"}, "abstract": "Sick-leave due to COVID-19 vary in length and might lead to re-current episodes. The aim was to investigate recurrent sick leave due to COVID-19 during the first wave.\r\n\r\nThis is a registry-based cohort study. The study comprises all people with sickness benefit due to COVID-19 in Sweden in March 1-August 31, 2020. Data from the Swedish Social Insurance Agency, the Swedish National Board of Health and Welfare, and Statistics Sweden were merged.\r\n\r\nWithin the follow-up period of 4 months, 11,955 people were subject to sickness benefit due to COVID-19, whereof 242 people (2.0%) took recurrent sick leave due to COVID-19, and of those 136 (56.2%) remained on sick leave at the end of follow-up. People with recurrent sick leave were older, more often women, and more likely to have been on sick leave prior to the COVID-19 pandemic.\r\n\r\nA group of people presented with recurrent sick leave due to COVID-19. For half of them, the second sick leave lasted throughout the follow-up. People with recurrent sick leave differ in several aspects from those with shorter sick leave. To capture long-term sick-leave patterns due to COVID-19, a longer period of follow-up is needed.", "doi": "10.1186/s12889-021-11918-y", "pmid": "34674673", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11918-y"}], "notes": [], "created": "2021-10-26T18:11:12.252Z", "modified": "2022-02-17T12:20:09.405Z"}, {"entity": "publication", "iuid": "258c795b973e4ab0a2adf939ddf7850b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/258c795b973e4ab0a2adf939ddf7850b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/258c795b973e4ab0a2adf939ddf7850b"}}, "title": "Implementation Science for Managers and Healthcare Organizations Responding to Emergencies", "authors": [{"family": "\u00d8vretveit", "given": "John", "initials": "J", "orcid": "0000-0001-9668-0175", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82d14033e7314a27a9ac093d99058bc8.json"}}, {"family": "Ohrling", "given": "Mikael", "initials": "M"}], "type": "journal-article", "published": "2021-10-21", "journal": {"title": "Glob Implement Res Appl", "issn": "2662-9275", "issn-l": null}, "abstract": null, "doi": "10.1007/s43477-021-00025-0", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:34:02.123Z", "modified": "2021-10-26T18:34:02.202Z"}, {"entity": "publication", "iuid": "6e938e1c59d2428bb1f45af94644ba6c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e938e1c59d2428bb1f45af94644ba6c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e938e1c59d2428bb1f45af94644ba6c"}}, "title": "Immunogenicity and safety of AZD1222 (ChAdOx1 nCoV-19) against SARS-CoV-2 in Japan: A double-blind, randomized controlled phase 1/2 trial.", "authors": [{"family": "Asano", "given": "Michiko", "initials": "M"}, {"family": "Okada", "given": "Hiroshi", "initials": "H"}, {"family": "Itoh", "given": "Yohji", "initials": "Y"}, {"family": "Hirata", "given": "Hajime", "initials": "H"}, {"family": "Ishikawa", "given": "Kensuke", "initials": "K"}, {"family": "Yoshida", "given": "Erika", "initials": "E"}, {"family": "Matsui", "given": "Akiko", "initials": "A"}, {"family": "Kelly", "given": "Elizabeth J", "initials": "EJ"}, {"family": "Shoemaker", "given": "Kathryn", "initials": "K"}, {"family": "Olsson", "given": "Urban", "initials": "U"}, {"family": "Vekemans", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2021-10-21", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712"}, "abstract": "Immunogenicity and safety of the AZD1222 (ChAdOx1 nCoV-19) vaccine was evaluated in Japanese adults in an ongoing phase 1/2, randomized, double-blind, parallel-group, placebo-controlled, multicenter trial (NCT04568031).\n\nAdults (N=256; age \u226518 years) seronegative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were stratified by age into 18-55- (n=128), 56-69- (n=86), and \u226570-year-old cohorts (n=42), then randomized 3:1 to receive AZD1222 or placebo (2 intramuscular injections 4 weeks apart). Immunogenicity and safety were coprimary endpoints. Data collected up to Day 57 are reported.\n\nPositive seroresponses to SARS-CoV-2 spike and receptor-binding domain antigens were seen in all 174 participants who received 2 doses of AZD1222. Neutralizing antibody seroresponses were seen in 67.5%, 60.3%, and 50.0% of participants receiving AZD1222 aged 18-55, 56-69, and \u226570 years, respectively. Solicited adverse events (AEs) were typically mild/moderate in severity and included injection site pain and tenderness, malaise, fatigue, muscle pains, and headache. Common unsolicited AEs included injection site pain and tenderness, fatigue, and elevated body temperature. No vaccine-related serious AEs or deaths were reported.\n\nAZD1222 elicited a strong humoral immune response against SARS-CoV-2 and was well tolerated in Japanese participants, including elderly participants.", "doi": "10.1016/j.ijid.2021.10.030", "pmid": "34688944", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)00818-3"}, {"db": "ClinicalTrials.gov", "key": "NCT04568031"}], "notes": [], "created": "2021-10-26T18:19:19.803Z", "modified": "2021-10-26T18:19:19.816Z"}, {"entity": "publication", "iuid": "09e3fbede2484edabd3786ae8bd64fd5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/09e3fbede2484edabd3786ae8bd64fd5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/09e3fbede2484edabd3786ae8bd64fd5"}}, "title": "Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia: The COVID STEROID 2 Randomized Trial.", "authors": [{"family": "COVID STEROID 2 Trial Group", "given": "", "initials": ""}, {"family": "Munch", "given": "Marie W", "initials": "MW"}, {"family": "Myatra", "given": "Sheila N", "initials": "SN"}, {"family": "Vijayaraghavan", "given": "Bharath Kumar Tirupakuzhi", "initials": "BKT"}, {"family": "Saseedharan", "given": "Sanjith", "initials": "S"}, {"family": "Benfield", "given": "Thomas", "initials": "T"}, {"family": "Wahlin", "given": "Rebecka R", "initials": "RR"}, {"family": "Rasmussen", "given": "Bodil S", "initials": "BS"}, {"family": "Andreasen", "given": "Anne Sofie", "initials": "AS"}, {"family": "Poulsen", "given": "Lone M", "initials": "LM"}, {"family": "Cioccari", "given": "Luca", "initials": "L"}, {"family": "Khan", "given": "Mohd S", "initials": "MS"}, {"family": "Kapadia", "given": "Farhad", "initials": "F"}, {"family": "Divatia", "given": "Jigeeshu V", "initials": "JV"}, {"family": "Br\u00f8chner", "given": "Anne C", "initials": "AC"}, {"family": "Bestle", "given": "Morten H", "initials": "MH"}, {"family": "Helleberg", "given": "Marie", "initials": "M"}, {"family": "Michelsen", "given": "Jens", "initials": "J"}, {"family": "Padmanaban", "given": "Ajay", "initials": "A"}, {"family": "Bose", "given": "Neeta", "initials": "N"}, {"family": "M\u00f8ller", "given": "Anders", "initials": "A"}, {"family": "Borawake", "given": "Kapil", "initials": "K"}, {"family": "Kristiansen", "given": "Klaus T", "initials": "KT"}, {"family": "Shukla", "given": "Urvi", "initials": "U"}, {"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Dixit", "given": "Subhal", "initials": "S"}, {"family": "Ulrik", "given": "Charlotte S", "initials": "CS"}, {"family": "Amin", "given": "Pravin R", "initials": "PR"}, {"family": "Chawla", "given": "Rajesh", "initials": "R"}, {"family": "Wamberg", "given": "Christian A", "initials": "CA"}, {"family": "Shah", "given": "Mehul S", "initials": "MS"}, {"family": "Darfelt", "given": "Iben S", "initials": "IS"}, {"family": "J\u00f8rgensen", "given": "Vibeke L", "initials": "VL"}, {"family": "Smitt", "given": "Margit", "initials": "M"}, {"family": "Granholm", "given": "Anders", "initials": "A"}, {"family": "Kj\u00e6r", "given": "Maj-Brit N", "initials": "MN"}, {"family": "M\u00f8ller", "given": "Morten H", "initials": "MH"}, {"family": "Meyhoff", "given": "Tine S", "initials": "TS"}, {"family": "Vesterlund", "given": "Gitte K", "initials": "GK"}, {"family": "Hammond", "given": "Naomi E", "initials": "NE"}, {"family": "Micallef", "given": "Sharon", "initials": "S"}, {"family": "Bassi", "given": "Abhinav", "initials": "A"}, {"family": "John", "given": "Oommen", "initials": "O"}, {"family": "Jha", "given": "Anubhuti", "initials": "A"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Jakob", "given": "Stephan M", "initials": "SM"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Lange", "given": "Theis", "initials": "T"}, {"family": "Kadam", "given": "Vaijayanti", "initials": "V"}, {"family": "Marcussen", "given": "Klaus V", "initials": "KV"}, {"family": "Hollenberg", "given": "Jacob", "initials": "J"}, {"family": "Hedman", "given": "Anders", "initials": "A"}, {"family": "Nielsen", "given": "Henrik", "initials": "H"}, {"family": "Schj\u00f8rring", "given": "Olav L", "initials": "OL"}, {"family": "Jensen", "given": "Marie Q", "initials": "MQ"}, {"family": "Leistner", "given": "Jens W", "initials": "JW"}, {"family": "Jonassen", "given": "Trine B", "initials": "TB"}, {"family": "Kristensen", "given": "Camilla M", "initials": "CM"}, {"family": "Clapp", "given": "Esben C", "initials": "EC"}, {"family": "Hjorts\u00f8", "given": "Carl J S", "initials": "CJS"}, {"family": "Jensen", "given": "Thomas S", "initials": "TS"}, {"family": "Halstad", "given": "Liv S", "initials": "LS"}, {"family": "Bak", "given": "Emilie R B", "initials": "ERB"}, {"family": "Zaabalawi", "given": "Reem", "initials": "R"}, {"family": "Metcalf-Clausen", "given": "Matias", "initials": "M"}, {"family": "Abdi", "given": "Suhayb", "initials": "S"}, {"family": "Hatley", "given": "Emma V", "initials": "EV"}, {"family": "Aksnes", "given": "Tobias S", "initials": "TS"}, {"family": "Gleipner-Andersen", "given": "Emil", "initials": "E"}, {"family": "Alarc\u00f3n", "given": "Arif F", "initials": "AF"}, {"family": "Yamin", "given": "Gabriel", "initials": "G"}, {"family": "Heymowski", "given": "Adam", "initials": "A"}, {"family": "Berggren", "given": "Anton", "initials": "A"}, {"family": "La Cour", "given": "Kirstine", "initials": "K"}, {"family": "Weihe", "given": "Sarah", "initials": "S"}, {"family": "Pind", "given": "Alison H", "initials": "AH"}, {"family": "Engstr\u00f8m", "given": "Janus", "initials": "J"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Venkatesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Perner", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-10-21", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484"}, "abstract": "A daily dose with 6 mg of dexamethasone is recommended for up to 10 days in patients with severe and critical COVID-19, but a higher dose may benefit those with more severe disease.\n\nTo assess the effects of 12 mg/d vs 6 mg/d of dexamethasone in patients with COVID-19 and severe hypoxemia.\n\nA multicenter, randomized clinical trial was conducted between August 2020 and May 2021 at 26 hospitals in Europe and India and included 1000 adults with confirmed COVID-19 requiring at least 10 L/min of oxygen or mechanical ventilation. End of 90-day follow-up was on August 19, 2021.\n\nPatients were randomized 1:1 to 12 mg/d of intravenous dexamethasone (n = 503) or 6 mg/d of intravenous dexamethasone (n = 497) for up to 10 days.\n\nThe primary outcome was the number of days alive without life support (invasive mechanical ventilation, circulatory support, or kidney replacement therapy) at 28 days and was adjusted for stratification variables. Of the 8 prespecified secondary outcomes, 5 are included in this analysis (the number of days alive without life support at 90 days, the number of days alive out of the hospital at 90 days, mortality at 28 days and at 90 days, and \u22651 serious adverse reactions at 28 days).\n\nOf the 1000 randomized patients, 982 were included (median age, 65 [IQR, 55-73] years; 305 [31%] women) and primary outcome data were available for 971 (491 in the 12 mg of dexamethasone group and 480 in the 6 mg of dexamethasone group). The median number of days alive without life support was 22.0 days (IQR, 6.0-28.0 days) in the 12 mg of dexamethasone group and 20.5 days (IQR, 4.0-28.0 days) in the 6 mg of dexamethasone group (adjusted mean difference, 1.3 days [95% CI, 0-2.6 days]; P = .07). Mortality at 28 days was 27.1% in the 12 mg of dexamethasone group vs 32.3% in the 6 mg of dexamethasone group (adjusted relative risk, 0.86 [99% CI, 0.68-1.08]). Mortality at 90 days was 32.0% in the 12 mg of dexamethasone group vs 37.7% in the 6 mg of dexamethasone group (adjusted relative risk, 0.87 [99% CI, 0.70-1.07]). Serious adverse reactions, including septic shock and invasive fungal infections, occurred in 11.3% in the 12 mg of dexamethasone group vs 13.4% in the 6 mg of dexamethasone group (adjusted relative risk, 0.83 [99% CI, 0.54-1.29]).\n\nAmong patients with COVID-19 and severe hypoxemia, 12 mg/d of dexamethasone compared with 6 mg/d of dexamethasone did not result in statistically significantly more days alive without life support at 28 days. However, the trial may have been underpowered to identify a significant difference.\n\nClinicalTrials.gov Identifier: NCT04509973 and ctri.nic.in Identifier: CTRI/2020/10/028731.", "doi": "10.1001/jama.2021.18295", "pmid": "34673895", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "2785529"}, {"db": "ClinicalTrials.gov", "key": "NCT04509973"}], "notes": [], "created": "2021-10-26T18:09:59.402Z", "modified": "2021-10-26T18:10:15.618Z"}, {"entity": "publication", "iuid": "b708ee46f2fc46ba9e5b696c9ee88580", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b708ee46f2fc46ba9e5b696c9ee88580.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b708ee46f2fc46ba9e5b696c9ee88580"}}, "title": "Distress Levels of Parents of Children with Neurodevelopmental Disorders during the COVID-19 Pandemic: A Comparison between Italy and Australia.", "authors": [{"family": "Burnett", "given": "Dayle", "initials": "D", "orcid": "0000-0003-0943-7973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33de85e857374d3b813fa2a886b489f7.json"}}, {"family": "Masi", "given": "Anne", "initials": "A"}, {"family": "Mendoza Diaz", "given": "Antonio", "initials": "A"}, {"family": "Rizzo", "given": "Renata", "initials": "R"}, {"family": "Lin", "given": "Ping-I", "initials": "PI", "orcid": "0000-0002-9739-7184", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/359146aaef914f14873beee4b6b43bcf.json"}}, {"family": "Eapen", "given": "Valsamma", "initials": "V", "orcid": "0000-0001-6296-8306", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e5564f68ee14bc4ba80b06b06997f90.json"}}], "type": "journal article", "published": "2021-10-21", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "21", "issn-l": null}, "abstract": "Parents of children with a neurodevelopmental disorder (NDD) report higher levels of distress compared to those of typically developing children. Distress levels may be heightened by the restrictions associated with the COVID-19 pandemic. However, it is unclear whether distress levels of parents varied by the diagnosis of neurodevelopmental disorder in children during the COVID-19 pandemic. This study aims to investigate whether parental distress was influenced by the type of NDD. Participants were from Australia (N = 196) and Italy (N = 200); the parents of children aged 3-18 were invited to complete an online self-reported survey which included the 6-item Kessler Psychological Distress Scale (K6) to determine parental distress. The results show that intellectual or learning disorder (ILD) is a major contributor to parental distress compared to other NDDs in both Australia and Italy. Moreover, the worsening of symptomatic changes in children with NDDs was significantly associated with parental distress. The differences between the two countries in terms of the pandemic impact, however, were not statistically significant. The results suggest that intervention strategies need to be tailored for individual clinical information and factor in the society's stringency level of anti-contagion policies to improve parental wellbeing.", "doi": "10.3390/ijerph182111066", "pmid": "34769585", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182111066"}, {"db": "pmc", "key": "PMC8583226"}, {"db": "figshare", "key": "10.6084/m9. figshare.16528998"}], "notes": [], "created": "2021-11-26T15:10:38.936Z", "modified": "2021-11-26T15:10:48.513Z"}, {"entity": "publication", "iuid": "04f67edcbc33433ab52163c3ab8b2591", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/04f67edcbc33433ab52163c3ab8b2591.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/04f67edcbc33433ab52163c3ab8b2591"}}, "title": "Advances and Utility of the Human Plasma Proteome", "authors": [{"family": "Deutsch", "given": "Eric W", "initials": "EW", "orcid": "0000-0001-8732-0928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a79e829ef590450696ffa9be36818a15.json"}}, {"family": "Omenn", "given": "Gilbert S", "initials": "GS", "orcid": "0000-0002-8976-6074", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be6adfe65b8345da8799a7d6af35c38d.json"}}, {"family": "Sun", "given": "Zhi", "initials": "Z", "orcid": "0000-0003-3324-6851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bc55a74b03b412b86616badb068af08.json"}}, {"family": "Maes", "given": "Michal", "initials": "M", "orcid": "0000-0002-7406-3982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cff13791bbc0457a89657357e2f6febf.json"}}, {"family": "Pernemalm", "given": "Maria", "initials": "M", "orcid": "0000-0003-4624-031X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6801d3242ee544a59d77ccd7256a4a30.json"}}, {"family": "Palaniappan", "given": "Krishnan K", "initials": "KK", "orcid": "0000-0003-0203-9016", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0de4251e52634dfda3157543df4187c5.json"}}, {"family": "Letunica", "given": "Natasha", "initials": "N", "orcid": "0000-0003-3604-1536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40ecd7338e3245c3a25614938b63ecf1.json"}}, {"family": "Vandenbrouck", "given": "Yves", "initials": "Y", "orcid": "0000-0002-1292-373X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12d928faa9d642eda7c27008bf2a85a6.json"}}, {"family": "Brun", "given": "Virginie", "initials": "V", "orcid": "0000-0002-9098-8707", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff2f9882dc0c447fa7dfdfd812aeac75.json"}}, {"family": "Tao", "given": "Sheng ce", "initials": "Sc", "orcid": "0000-0002-9210-1823", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e5c94e5298840c38b9aabcdd91599ac.json"}}, {"family": "Yu", "given": "Xiaobo", "initials": "X"}, {"family": "Geyer", "given": "Philipp E", "initials": "PE", "orcid": "0000-0001-7980-4826", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cec492eb8b214af1b35c081249a43ef2.json"}}, {"family": "Ignjatovic", "given": "Vera", "initials": "V", "orcid": "0000-0002-5548-5813", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b94d0fd7f56d491785df601cb8851722.json"}}, {"family": "Moritz", "given": "Robert L", "initials": "RL", "orcid": "0000-0002-3216-9447", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2aa533b8b0cb46689bf9862952bbc417.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67a59fa5de37434c8b7151039c192a37.json"}}], "type": "journal-article", "published": "2021-10-21", "journal": {"title": "J. Proteome Res.", "issn": "1535-3893", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The study of proteins circulating in blood offers tremendous opportunities to diagnose, stratify, or possibly prevent diseases. With recent technological advances and the urgent need to understand the effects of COVID-19, the proteomic analysis of blood-derived serum and plasma has become even more important for studying human biology and pathophysiology. Here we provide views and perspectives about technological developments and possible clinical applications that use mass-spectrometry(MS)- or affinity-based methods. We discuss examples where plasma proteomics contributed valuable insights into SARS-CoV-2 infections, aging, and hemostasis and the opportunities offered by combining proteomics with genetic data. As a contribution to the Human Proteome Organization (HUPO) Human Plasma Proteome Project (HPPP), we present the Human Plasma PeptideAtlas build 2021-07 that comprises 4395 canonical and 1482 additional nonredundant human proteins detected in 240 MS-based experiments. In addition, we report the new Human Extracellular Vesicle PeptideAtlas 2021-06, which comprises five studies and 2757 canonical proteins detected in extracellular vesicles circulating in blood, of which 74% (2047) are in common with the plasma PeptideAtlas. Our overview summarizes the recent advances, impactful applications, and ongoing challenges for translating plasma proteomics into utility for precision medicine.", "doi": "10.1021/acs.jproteome.1c00657", "pmid": "34672606", "labels": {"Category: Biochemistry": null, "Type: Review": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.1021/acs.jproteome.1c00657.s002", "description": "Union of proteins in both the plasma and blood extracellular vesicle PeptideAtlas builds, along with the crudely estimated log10 abundances and functional annotations"}], "notes": [], "created": "2021-10-26T14:47:22.298Z", "modified": "2021-11-19T10:45:18.691Z"}, {"entity": "publication", "iuid": "0868bd77cf724196bd1351491fb6f27e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0868bd77cf724196bd1351491fb6f27e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0868bd77cf724196bd1351491fb6f27e"}}, "title": "Acute and post-acute neurological manifestations of COVID-19: present findings, critical appraisal, and future directions.", "authors": [{"family": "Beghi", "given": "Ettore", "initials": "E", "orcid": "0000-0003-2542-0469", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08608536dadb4c84af6f3ea9c0a9f7e4.json"}}, {"family": "Giussani", "given": "Giorgia", "initials": "G"}, {"family": "Westenberg", "given": "Erica", "initials": "E"}, {"family": "Allegri", "given": "Ricardo", "initials": "R"}, {"family": "Garcia-Azorin", "given": "David", "initials": "D"}, {"family": "Guekht", "given": "Alla", "initials": "A"}, {"family": "Frontera", "given": "Jennifer", "initials": "J"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Mangialasche", "given": "Francesca", "initials": "F"}, {"family": "Mukaetova-Ladinska", "given": "Elizabeta B", "initials": "EB"}, {"family": "Prasad", "given": "Kameshwar", "initials": "K"}, {"family": "Chowdhary", "given": "Neerja", "initials": "N"}, {"family": "Winkler", "given": "Andrea Sylvia", "initials": "AS"}], "type": "journal article", "published": "2021-10-21", "journal": {"title": "J Neurol", "issn": "1432-1459", "issn-l": null}, "abstract": "Acute and post-acute neurological symptoms, signs and diagnoses have been documented in an increasing number of patients infected by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which causes Coronavirus Disease 2019 (COVID-19). In this review, we aimed to summarize the current literature addressing neurological events following SARS-CoV-2 infection, discuss limitations in the existing literature and suggest future directions that would strengthen our understanding of the neurological sequelae of COVID-19. The presence of neurological manifestations (symptoms, signs or diagnoses) both at the onset or during SARS-CoV-2 infection is associated with a more severe disease, as demonstrated by a longer hospital stay, higher in-hospital death rate or the continued presence of sequelae at discharge. Although biological mechanisms have been postulated for these findings, evidence-based data are still lacking to clearly define the incidence, range of characteristics and outcomes of these manifestations, particularly in non-hospitalized patients. In addition, data from low- and middle-income countries are scarce, leading to uncertainties in the measure of neurological findings of COVID-19, with reference to geography, ethnicity, socio-cultural settings, and health care arrangements. As a consequence, at present a specific phenotype that would specify a post-COVID (or long-COVID) neurological syndrome has not yet been identified.", "doi": "10.1007/s00415-021-10848-4", "pmid": "34674005", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00415-021-10848-4"}], "notes": [], "created": "2021-10-26T18:10:35.291Z", "modified": "2021-10-26T18:10:47.822Z"}, {"entity": "publication", "iuid": "ede3ddee591a4d2492385a9f0b07bf27", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ede3ddee591a4d2492385a9f0b07bf27.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ede3ddee591a4d2492385a9f0b07bf27"}}, "title": "Twinning during the pandemic: Evidence of selection in utero.", "authors": [{"family": "Catalano", "given": "Ralph", "initials": "R", "orcid": "0000-0001-7240-415X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ccf81f67c4f46dc92acca88a7344cc9.json"}}, {"family": "Bruckner", "given": "Tim", "initials": "T"}, {"family": "Casey", "given": "Joan A", "initials": "JA"}, {"family": "Gemmill", "given": "Alison", "initials": "A", "orcid": "0000-0001-5879-9730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dca36e3db9724dce8360c5f7b362151d.json"}}, {"family": "Margerison", "given": "Claire", "initials": "C", "orcid": "0000-0003-0692-2252", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06be6014da274b2886af1733870d98b0.json"}}, {"family": "Hartig", "given": "Terry", "initials": "T"}], "type": "journal article", "published": "2021-10-20", "journal": {"title": "Evol Med Public Health", "issn": "2050-6201", "volume": "9", "issue": "1", "pages": "374-382", "issn-l": null}, "abstract": "The suspicion that a population stressor as profound as the COVID-19 pandemic would increase preterm birth among cohorts in gestation at its outset has not been supported by data collected in 2020. An evolutionary perspective on this circumstance suggests that natural selection in utero, induced by the onset of the pandemic, caused pregnancies that would otherwise have produced a preterm birth to end early in gestation as spontaneous abortions. We test this possibility using the odds of a live-born twin among male births in Norway as an indicator of the depth of selection in birth cohorts.\n\nWe apply Box-Jenkins methods to 50 pre-pandemic months to estimate counterfactuals for the nine birth cohorts in gestation in March 2020 when the first deaths attributable to SARS-CoV-2 infection occurred in Norway. We use Alwan and Roberts outlier detection methods to discover any sequence of outlying values in the odds of a live-born twin among male births in exposed birth cohorts.\n\nWe find a downward level shift of 27% in the monthly odds of a twin among male births beginning in May and persisting through the remainder of 2020.\n\nConsistent with evolutionary theory and selection in utero, birth cohorts exposed in utero to the onset of the COVID-19 pandemic yielded fewer male twins than expected.\n\nOur finding of fewer than expected male twin births during the onset of the COVID-19 pandemic provides more evidence that evolution continues to affect the characteristics and health of contemporary populations.", "doi": "10.1093/emph/eoab033", "pmid": "34858596", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "eoab033"}, {"db": "pmc", "key": "PMC8634460"}], "notes": [], "created": "2021-12-18T18:06:55.901Z", "modified": "2021-12-18T18:07:03.516Z"}, {"entity": "publication", "iuid": "c10ab7f808754f1a8e2812b74e8a7985", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c10ab7f808754f1a8e2812b74e8a7985.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c10ab7f808754f1a8e2812b74e8a7985"}}, "title": "Trends of Anger and Physical Aggression in Russian Women During COVID-19 Lockdown.", "authors": [{"family": "Klimovich-Mickael", "given": "Alexandra", "initials": "A"}, {"family": "Kubick", "given": "Norwin", "initials": "N"}, {"family": "Milanesi", "given": "Elena", "initials": "E"}, {"family": "Dobre", "given": "Maria", "initials": "M"}, {"family": "\u0141azarczyk", "given": "Marzena", "initials": "M"}, {"family": "Wijas", "given": "Baraba", "initials": "B"}, {"family": "Sacharczuk", "given": "Mariusz", "initials": "M"}, {"family": "Mickael", "given": "Michel-Edwar", "initials": "ME"}], "type": "journal article", "published": "2021-10-20", "journal": {"title": "Front Glob Womens Health", "issn": "2673-5059", "volume": "2", "pages": "698151", "issn-l": null}, "abstract": "The effect of social lockdown during the COVID-19 outbreak on female aggressiveness is not well known. The strict measures of lockdown have resulted in millions of people, worldwide, confined to their homes during the pandemic. However, the consequence of lockdown strategies on females' psychological status including aggressiveness has not yet been investigated. We conducted a cross-sectional study on 31 Russian females' homemakers who are participants in an online fitness platform to investigate the immediate anxiety, depression, and aggression experienced under strict lockdown measures. The participants were surveyed using the hospital anxiety depression scale (HADS) and the Buss-Perry Aggression Questionnaire. We used descriptive and statistical methods to investigate the prevalence of these emotions among two age groups (20-35 and 36-65 years). We found that moderate anxiety prevalence was 77.4% in the entire group while mild depression was 54.8%. Interestingly, the whole sample showed a high level of angriness (p = 0.0002) and physical aggression (p = 0.019). These two emotions seem to be more prevalent than other negative emotions such as hostility, verbal aggression. This relationship was not dependent on age. Overall, there is a significant worsening in female aggression that could lead to higher chances of female victimization and being subjected to partner violence. Future policies designing lockdown strategies should consider this effect on active female homemakers. Due to the small size of our cohort, our results are only indicative of data trends. Larger studies are still needed to confirm the current findings.", "doi": "10.3389/fgwh.2021.698151", "pmid": "34816235", "labels": {"Type: Journal article": null, "Topics: Register-based research": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8593940"}], "notes": [], "created": "2021-11-26T13:17:10.899Z", "modified": "2021-12-18T18:23:22.161Z"}, {"entity": "publication", "iuid": "475cebda2a5f43bc9184f6963321058d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/475cebda2a5f43bc9184f6963321058d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/475cebda2a5f43bc9184f6963321058d"}}, "title": "Socio-economic and psychological impact of COVID-19 pandemic in a Spanish cohort BIOVAL-D-COVID-19 study protocol.", "authors": [{"family": "Miranda-Mendizabal", "given": "Andrea", "initials": "A"}, {"family": "Recoder", "given": "Silvia", "initials": "S"}, {"family": "Sebastian", "given": "Ester Calbo", "initials": "EC"}, {"family": "Casajuana Closas", "given": "Marc", "initials": "M"}, {"family": "Leiva Ure\u00f1a", "given": "David", "initials": "D"}, {"family": "Manolov", "given": "Rumen", "initials": "R"}, {"family": "Matilla Santander", "given": "Nuria", "initials": "N"}, {"family": "Forero", "given": "Carlos G", "initials": "CG"}, {"family": "Castellv\u00ed", "given": "Pere", "initials": "P"}], "type": "journal article", "published": "2021-10-20", "journal": {"title": "Gac Sanit", "issn": "1578-1283", "issn-l": null}, "abstract": "SARS-CoV-2 outbreak has a negative psychological impact among general population. Data comparing mental health status before and during the outbreak is needed. The BIOVAL-D-COVID-19 study assess the socio-economic and psychological impact of the COVID-19 pandemic and lockdown in a representative sample of non-institutionalized Spanish adult population, and estimate the incidence of mental health disorders, including suicidal behaviours, and possible related factors.\n\nObservational longitudinal study including two online surveys: baseline survey (T0) performed during 2019 and follow-up survey (T1) conducted 12-month later. The latter included nine sections: socio-demographic, health status, mental health, employment conditions and status, material deprivation, use of healthcare services, intimate partner violence and resilience. Four of the nine sections are administered in T0 and T1 assessments. Longitudinal data analyses will estimate adjusted incidence rates of mental health disorders using Poisson regression models. Risk and protective factors will be analysed through multiple logistic regression models.", "doi": "10.1016/j.gaceta.2021.10.003", "pmid": "34836679", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0213-9111(21)00180-1"}, {"db": "pmc", "key": "PMC8526442"}], "notes": [], "created": "2021-12-18T18:13:46.340Z", "modified": "2021-12-18T18:14:03.345Z"}, {"entity": "publication", "iuid": "5ac427dcbd894ef981cceb9d3f478952", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5ac427dcbd894ef981cceb9d3f478952.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5ac427dcbd894ef981cceb9d3f478952"}}, "title": "Gender gap in journal submissions and peer review during the first wave of the COVID-19 pandemic. A study on 2329 Elsevier journals.", "authors": [{"family": "Squazzoni", "given": "Flaminio", "initials": "F", "orcid": "0000-0002-6503-6077", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b124ceca40884addab841186835c2e43.json"}}, {"family": "Bravo", "given": "Giangiacomo", "initials": "G", "orcid": "0000-0003-2837-0137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e2bd815dac24aabb080893c4d7d1051.json"}}, {"family": "Grimaldo", "given": "Francisco", "initials": "F", "orcid": "0000-0002-1357-7170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6be3f24db5f44f26ae1ed1fb16c5b760.json"}}, {"family": "Garc\u00eda-Costa", "given": "Daniel", "initials": "D"}, {"family": "Farjam", "given": "Mike", "initials": "M"}, {"family": "Mehmani", "given": "Bahar", "initials": "B", "orcid": "0000-0003-4038-4531", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bbbcfa3265dc4cd6a804e4515137ee1f.json"}}], "type": "journal article", "published": "2021-10-20", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0257919", "issn-l": "1932-6203"}, "abstract": "During the early months of the COVID-19 pandemic, there was an unusually high submission rate of scholarly articles. Given that most academics were forced to work from home, the competing demands for familial duties may have penalized the scientific productivity of women. To test this hypothesis, we looked at submitted manuscripts and peer review activities for all Elsevier journals between February and May 2018-2020, including data on over 5 million authors and referees. Results showed that during the first wave of the pandemic, women submitted proportionally fewer manuscripts than men. This deficit was especially pronounced among more junior cohorts of women academics. The rate of the peer-review invitation acceptance showed a less pronounced gender pattern with women taking on a greater service responsibility for journals, except for health & medicine, the field where the impact of COVID-19 research has been more prominent. Our findings suggest that the first wave of the pandemic has created potentially cumulative advantages for men.", "doi": "10.1371/journal.pone.0257919", "pmid": "34669713", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-15330"}], "notes": [], "created": "2021-10-21T04:37:34.903Z", "modified": "2021-10-21T04:37:35.057Z"}, {"entity": "publication", "iuid": "1992a95857644f16a0b3f26aeb5ed5af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1992a95857644f16a0b3f26aeb5ed5af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1992a95857644f16a0b3f26aeb5ed5af"}}, "title": "COVID-19: A comprehensive review of current guidelines and personal perspectives from neurointerventionists.", "authors": [{"family": "Lee", "given": "Seon-Kyu", "initials": "SK"}, {"family": "S\u00f6derman", "given": "Michael", "initials": "M"}, {"family": "Altschul", "given": "David J", "initials": "DJ", "orcid": "0000-0002-5130-1378", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8b7025f25174eec917fe4491b64765d.json"}}], "type": "journal article", "published": "2021-10-20", "journal": {"title": "Interv Neuroradiol", "issn": "2385-2011", "pages": "15910199211037807", "issn-l": null}, "abstract": null, "doi": "10.1177/15910199211037807", "pmid": "34669531", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-10-21T04:38:02.457Z", "modified": "2021-10-21T04:38:17.971Z"}, {"entity": "publication", "iuid": "cc6244441ef447f6834249322c7adfc4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc6244441ef447f6834249322c7adfc4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc6244441ef447f6834249322c7adfc4"}}, "title": "The role of ventilatory support for long-term outcomes after critical infection with COVID-19: A prospective cohort study.", "authors": [{"family": "Hanna", "given": "Gabriel", "initials": "G"}, {"family": "Bankler", "given": "Sara", "initials": "S"}, {"family": "Schandl", "given": "Anna", "initials": "A"}, {"family": "Ro\u00ebl", "given": "Mari", "initials": "M"}, {"family": "Hedman", "given": "Anders", "initials": "A"}, {"family": "Franko", "given": "Mikael Andersson", "initials": "MA"}, {"family": "Lyng\u00e5", "given": "Patrik", "initials": "P"}, {"family": "Geborek", "given": "Anne", "initials": "A"}, {"family": "Joelsson-Alm", "given": "Eva", "initials": "E", "orcid": "0000-0002-9041-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07a091265e654b21bc27fa14b93e4ec0.json"}}, {"family": "S\u00f6derberg", "given": "M\u00e5rten", "initials": "M"}, {"family": "Darlington", "given": "Pernilla", "initials": "P"}], "type": "journal article", "published": "2021-10-19", "journal": {"title": "Clin Respir J", "issn": "1752-699X", "issn-l": null}, "abstract": "The full range of long-term health consequences in ICU survivors with COVID-19 is unclear. This study aims to investigate the role of ventilatory support for long-term pulmonary impairment in critically ill patients and further to identify risk factors for prolonged radiological recovery.\n\nA prospective observational study from a single general hospital, including all with COVID-19 admitted to ICU between March and August 2020, investigating the association between ventilatory support and the extent of residual parenchymal changes on chest CT scan and measurement of lung volumes at follow-up comparing high-flow nasal oxygen (HFNO) or non-invasive ventilation (NIV) with invasive ventilation. A semi-quantitative score (CT involvement score) based on lobar involvement and a total score for all five lobes was used to estimate residual parenchymal changes. The association was calculated with logistic regression and adjusted for age, sex, smoking and severity of illness.\n\nAmong the 187 eligible, 86 had a chest CT scan and 76 a pulmonary function test at the follow-up with a median time of six months after ICU discharge. Residual lung changes were seen in 74%. The extent of pulmonary changes was similar regardless of ventilatory support, but patients with invasive ventilation had a lower total lung capacity 84% vs 92% of predicted (p<0.001).\n\nThe majority of ICU-treated patients with COVID-19 had residual lung changes at six months follow-up regardless of ventilator support or not, but the total lung capacity was lower in those treated with invasive ventilation.", "doi": "10.1111/crj.13453", "pmid": "34665518", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-21T04:53:21.266Z", "modified": "2021-10-21T04:53:21.356Z"}, {"entity": "publication", "iuid": "8d53640d5b78486ba15544de1fdba5cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d53640d5b78486ba15544de1fdba5cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d53640d5b78486ba15544de1fdba5cf"}}, "title": "Social Distancing Policies in the Coronavirus Battle: A Comparison of Denmark and Sweden.", "authors": [{"family": "Seing", "given": "Ida", "initials": "I"}, {"family": "Th\u00f3rn\u00fd Stef\u00e1nsd\u00f3ttir", "given": "Nina", "initials": "N", "orcid": "0000-0002-7748-5347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c7da04bf6284cab9a62b9d6faf64b06.json"}}, {"family": "Wassar Kirk", "given": "Jeanette", "initials": "J", "orcid": "0000-0002-2680-0917", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f32255961c141298acfba1fbaac9824.json"}}, {"family": "Andersen", "given": "Ove", "initials": "O"}, {"family": "Tj\u00f8rnh\u00f8j-Thomsen", "given": "Tine", "initials": "T"}, {"family": "Kallemose", "given": "Thomas", "initials": "T"}, {"family": "Vedung", "given": "Evert", "initials": "E"}, {"family": "Vrangb\u00e6k", "given": "Karsten", "initials": "K"}, {"family": "Nilsen", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2021-10-19", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "20", "pages": null}, "abstract": "Social distancing measures have been a key component in government strategies to mitigate COVID-19 globally. Based on official documents, this study aimed to identify, compare and analyse public social distancing policy measures adopted in Denmark and Sweden regarding the coronavirus from 1 March 2020 until 1 October 2020. A key difference was the greater emphasis on laws and executive orders (sticks) in Denmark, which allowed the country to adopt many stricter policy measures than Sweden, which relied mostly on general guidelines and recommendations (sermons). The main policy adopters in Denmark were the government and the Danish Parliament, whereas the Public Health Agency issued most policies in Sweden, reflecting a difference in political governance and administrative structure in the two countries. During the study period, Sweden had noticeably higher rates of COVID-19 deaths and hospitalizations per 100,000 population than Denmark, yet it is difficult to determine the impact or relative effectiveness of sermons and sticks, particularly with regard to broader and longer-term health, economic and societal effects.", "doi": "10.3390/ijerph182010990", "pmid": "34682734", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182010990"}], "notes": [], "created": "2021-10-26T18:16:33.651Z", "modified": "2022-02-17T12:04:44.526Z"}, {"entity": "publication", "iuid": "ba97b2dc080946b7997eb15dcd2e098f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ba97b2dc080946b7997eb15dcd2e098f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ba97b2dc080946b7997eb15dcd2e098f"}}, "title": "Lack of Trust, Insufficient knowledge and Risk denial; an in-depth Understanding of Health workers Barriers to uptake of the Covid-19 vaccine at Iganga Hospital Eastern Uganda, and Mengo Hospital Kampala Uganda", "authors": [{"family": "Muhamadi", "given": "Lubega", "initials": "L"}, {"family": "Edith", "given": "Namulema", "initials": "N"}, {"family": "James", "given": "Waako", "initials": "W"}, {"family": "Tumwesigye", "given": "Nazarius Mbona", "initials": "NM"}, {"family": "Museene", "given": "Safinah Kisu", "initials": "SK"}, {"family": "Mukakaarisa", "given": "Hellen", "initials": "H"}, {"family": "Peterson", "given": "Stefan Swartling", "initials": "SS"}, {"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM"}], "type": "posted-content", "published": "2021-10-19", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.10.13.21264920", "pmid": null, "labels": {"Category: Public Health": null, "Type: Preprint": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:41:01.093Z", "modified": "2021-11-29T06:08:28.303Z"}, {"entity": "publication", "iuid": "4efc878827a54611ba59ad34ee90434b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4efc878827a54611ba59ad34ee90434b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4efc878827a54611ba59ad34ee90434b"}}, "title": "Impact of SARS-CoV-2 infection on vaccine-induced immune responses over time", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Ng", "given": "Henry", "initials": "H"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "posted-content", "published": "2021-10-19", "journal": {"title": "MedRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.10.16.21264948", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Health": null, "Research Area: High-throughput and high-content serology": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-11-18T16:32:34.201Z", "modified": "2023-06-19T14:28:13.106Z"}, {"entity": "publication", "iuid": "14d8fb377fab4b9ba81680ee27e65d48", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/14d8fb377fab4b9ba81680ee27e65d48.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/14d8fb377fab4b9ba81680ee27e65d48"}}, "title": "Humoral and cellular response to SARS-CoV-2 BNT162b2 mRNA vaccine in hemodialysis patients.", "authors": [{"family": "Melin", "given": "Jan", "initials": "J", "orcid": "0000-0003-3405-3154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e749d7c3ad7e40cfbb1f3bfda19ec05b.json"}}, {"family": "Svensson", "given": "Maria K", "initials": "MK"}, {"family": "Albinsson", "given": "Bo", "initials": "B"}, {"family": "Winqvist", "given": "Ola", "initials": "O"}, {"family": "Pauksens", "given": "Karlis", "initials": "K"}], "type": "journal article", "published": "2021-10-19", "journal": {"title": "BMC Immunol", "issn": "1471-2172", "issn-l": null, "volume": "22", "issue": "1", "pages": "70"}, "abstract": "Hemodialysis (HD) patients have an increased risk of acquiring infections due to many health care contacts and may, in addition, have a suboptimal response to vaccination and a high mortality from Covid-19 infection.\n\nIn 50 HD patients (mean age 69.4 years, 62% men) administration of SARS-CoV-2BNT162b2 mRNA vaccine began in Dec 2020 and the immune response was evaluated 7-15 weeks after the last dose. Levels of Covid-19 (SARS-CoV-2) IgG antibody against the nucleocapsid antigen (anti-N) and the Spike antigen (anti-S) and T-cell reactivity testing against the Spike protein using ELISPOT technology were evaluated.\n\nOut of 50 patients, anti-S IgG antibodies indicating a vaccine effect or previous Covid-19 infection, were detected in 37 (74%), 5 (10%) had a borderline response and 8 (16%) were negative after two doses of vaccine. T-cell responses were detected in 29 (58%). Of the 37 patients with anti-S antibodies, 25 (68%) had a measurable T-cell response. 2 (40%) out of 5 patients with borderline anti-S and 2 (25%) without anti-S had a concomitant T-cell response. Twenty-seven (54%) had both an antibody and T-cell response. IgG antibodies to anti-N indicating a previous Covid-19 disease were detected in 7 (14%) patients.\n\nMost HD patients develop a B- and/or T-cell response after vaccination against Covid-19 but approx. 20% had a limited immunological response. T-cell reactivity against Covid-19 was only present in a few of the anti-S antibody negative patients.", "doi": "10.1186/s12865-021-00458-0", "pmid": "34666683", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC8524400"}, {"db": "pii", "key": "10.1186/s12865-021-00458-0"}], "notes": [], "created": "2021-10-21T04:48:27.665Z", "modified": "2023-06-19T15:31:31.358Z"}, {"entity": "publication", "iuid": "f33dd0f2b2b84264b595cd9fd28bff7c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f33dd0f2b2b84264b595cd9fd28bff7c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f33dd0f2b2b84264b595cd9fd28bff7c"}}, "title": "Drug repurposing improves disease targeting 11-fold and can be augmented by network module targeting, applied to COVID-19.", "authors": [{"family": "Rivero-Garc\u00eda", "given": "In\u00e9s", "initials": "I"}, {"family": "Castresana-Aguirre", "given": "Miguel", "initials": "M"}, {"family": "Guglielmo", "given": "Luca", "initials": "L"}, {"family": "Guala", "given": "Dimitri", "initials": "D"}, {"family": "Sonnhammer", "given": "Erik L L", "initials": "ELL"}], "type": "journal article", "published": "2021-10-19", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "20687", "issn-l": "2045-2322"}, "abstract": "This analysis presents a systematic evaluation of the extent of therapeutic opportunities that can be obtained from drug repurposing by connecting drug targets with disease genes. When using FDA-approved indications as a reference level we found that drug repurposing can offer an average of an 11-fold increase in disease coverage, with the maximum number of diseases covered per drug being increased from 134 to 167 after extending the drug targets with their high confidence first neighbors. Additionally, by network analysis to connect drugs to disease modules we found that drugs on average target 4 disease modules, yet the similarity between disease modules targeted by the same drug is generally low and the maximum number of disease modules targeted per drug increases from 158 to 229 when drug targets are neighbor-extended. Moreover, our results highlight that drug repurposing is more dependent on target proteins being shared between diseases than on polypharmacological properties of drugs. We apply our drug repurposing and network module analysis to COVID-19 and show that Fostamatinib is the drug with the highest module coverage.", "doi": "10.1038/s41598-021-99721-y", "pmid": "34667255", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-99721-y"}, {"db": "URL", "key": "https://bitbucket.org/sonnhammergroup/unadrug", "description": "Code, raw data, analysis results, and figures are all available in bitbucket"}], "notes": [], "created": "2021-10-21T04:41:29.287Z", "modified": "2021-11-08T09:51:37.313Z"}, {"entity": "publication", "iuid": "c2942d61f471452ba1028a411f33f4a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2942d61f471452ba1028a411f33f4a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2942d61f471452ba1028a411f33f4a9"}}, "title": "Cardiorespiratory fitness and lifestyle on severe COVID-19 risk in 279,455 adults: a case control study.", "authors": [{"family": "Ekblom-Bak", "given": "Elin", "initials": "E", "orcid": "0000-0002-3901-7833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08a43b5b45864543a2583be45a2f1d10.json"}}, {"family": "V\u00e4is\u00e4nen", "given": "Daniel", "initials": "D"}, {"family": "Ekblom", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Blom", "given": "Victoria", "initials": "V"}, {"family": "Kallings", "given": "Lena V", "initials": "LV"}, {"family": "Hemmingsson", "given": "Erik", "initials": "E"}, {"family": "Andersson", "given": "Gunnar", "initials": "G"}, {"family": "Wallin", "given": "Peter", "initials": "P"}, {"family": "Salier Eriksson", "given": "Jane", "initials": "J"}, {"family": "Holmlund", "given": "Tobias", "initials": "T"}, {"family": "Lindwall", "given": "Magnus", "initials": "M"}, {"family": "Stenling", "given": "Andreas", "initials": "A"}, {"family": "L\u00f6nn", "given": "Amanda", "initials": "A"}], "type": "journal article", "published": "2021-10-19", "journal": {"title": "Int J Behav Nutr Phys Act", "issn": "1479-5868", "volume": "18", "issue": "1", "pages": "135", "issn-l": null}, "abstract": "The impact of cardiorespiratory fitness (CRF) and other lifestyle-related factors on severe COVID-19 risk is understudied. The present study aims to investigate lifestyle-related and socioeconomic factors as possible predictors of COVID-19, with special focus on CRF, and to further study whether these factors may attenuate obesity- and hypertension-related risks, as well as mediate associations between socioeconomic factors and severe COVID-19 risk.\n\nOut of initially 407,131 participants who participated in nationwide occupational health service screening between 1992 and 2020, n = 857 cases (70% men, mean age 49.9 years) of severe COVID-19 were identified. CRF was estimated using a sub-maximum cycle test, and other lifestyle variables were self-reported. Analyses were performed including both unmatched, n = 278,598, and sex-and age-matched, n = 3426, controls. Severe COVID-19 included hospitalization, intensive care or death due to COVID-19.\n\nPatients with more severe COVID-19 had significantly lower CRF, higher BMI, a greater presence of comorbidities and were more often daily smokers. In matched analyses, there was a graded decrease in odds for severe COVID-19 with each ml in CRF (OR = 0.98, 95% CI 0.970 to 0.998), and a two-fold increase in odds between the lowest and highest (< 32 vs. \u2265 46 ml\u00b7min-1\u00b7kg-1) CRF group. Higher BMI (per unit increase, OR = 1.09, 1.06 to 1.12), larger waist circumference (per cm, OR = 1.04, 1.02 to 1.06), daily smoking (OR = 0.60, 0.41 to 0.89) and high overall stress (OR = 1.36, 1.001 to 1.84) also remained significantly associated with severe COVID-19 risk. Obesity- and blood pressure-related risks were attenuated by adjustment for CRF and lifestyle variables. Mediation through CRF, BMI and smoking accounted for 9% to 54% of the associations between low education, low income and blue collar/low skilled occupations and severe COVID-19 risk. The results were consistent using either matched or unmatched controls.\n\nBoth lifestyle-related and socioeconomic factors were associated with risk of severe COVID-19. However, higher CRF attenuated the risk associated with obesity and high blood pressure, and mediated the risk associated with various socioeconomic factors. This emphasises the importance of interventions to maintain or increase CRF in the general population to strengthen the resilience to severe COVID-19, especially in high-risk individuals.", "doi": "10.1186/s12966-021-01198-5", "pmid": "34666788", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12966-021-01198-5"}], "notes": [], "created": "2021-10-21T04:47:47.784Z", "modified": "2021-10-21T04:47:47.858Z"}, {"entity": "publication", "iuid": "78490315e34845a5b5594d5e796d14d6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/78490315e34845a5b5594d5e796d14d6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/78490315e34845a5b5594d5e796d14d6"}}, "title": "COVID-19 mortality across occupations and secondary risks for elderly individuals in the household: A population register-based study.", "authors": [{"family": "Billingsley", "given": "Sunnee", "initials": "S"}, {"family": "Brand\u00e9n", "given": "Maria", "initials": "M"}, {"family": "Aradhya", "given": "Siddartha", "initials": "S"}, {"family": "Drefahl", "given": "Sven", "initials": "S"}, {"family": "Andersson", "given": "Gunnar", "initials": "G"}, {"family": "Mussino", "given": "Eleonora", "initials": "E"}], "type": "journal article", "published": "2021-10-19", "journal": {"title": "Scand J Work Environ Health", "issn": "1795-990X", "issn-l": null}, "abstract": "Objectives This is the first population-level study to examine inequalities in COVID-19 mortality according to working-age individuals' occupations and the indirect occupational effects on COVID-19 mortality of older individuals who live with them. Methods We used early-release data for the entire population of Sweden of all recorded COVID-19 deaths from 12 March 2020 to 23 February 2021, which we linked to administrative registers and occupational measures. Cox proportional hazard models assessed relative risks of COVID-19 mortality for the working-aged population registered in an occupation in December 2018 and the older population who lived with them. Results Among working aged-adults, taxi/bus drivers had the highest relative risk of COVID-19 mortality: over four times that of skilled workers in IT, economics, or administration when adjusted only for basic demographic characteristics. After adjusting for socioeconomic factors (education, income and country of birth), there are no occupational groups with clearly elevated (statistically significant) COVID-19 mortality. Neither a measure of exposure within occupations nor the share that generally can work from home were related to working-aged adults' risk of COVID-19 mortality. Instead of occupational factors, traditional socioeconomic risk factors best explained variation in COVID-19 mortality. Elderly individuals, however, faced higher COVID-19 mortality risk both when living with a delivery or postal worker or worker(s) in occupations that generally work from home less, even when their socioeconomic factors are taken into account. Conclusions Inequalities in COVID-19 mortality of working-aged adults were mostly based on traditional risk factors and not on occupational divisions or characteristics in Sweden. However, older individuals living with those who likely cannot work from home or work in delivery or postal services were a vulnerable group.", "doi": "10.5271/sjweh.3992", "pmid": "34665872", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "3992"}], "notes": [], "created": "2021-10-21T04:50:35.692Z", "modified": "2021-10-21T04:50:35.707Z"}, {"entity": "publication", "iuid": "d8ef63726b3b45bcb96b054a6655d41e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d8ef63726b3b45bcb96b054a6655d41e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d8ef63726b3b45bcb96b054a6655d41e"}}, "title": "Role and utility of COVID-19 laboratory testing in low-income and middle-income countries: protocol for rapid evidence synthesis.", "authors": [{"family": "Ouma", "given": "Ojiambo Kevin", "initials": "OK"}, {"family": "Ephraim", "given": "Kisangala", "initials": "K"}, {"family": "Loyce", "given": "Nakalembe", "initials": "N"}, {"family": "Namisango", "given": "Eve", "initials": "E"}, {"family": "Nalugoda", "given": "Fred", "initials": "F"}, {"family": "Ndagire", "given": "Regina", "initials": "R"}, {"family": "Wangi", "given": "Rachel Nante", "initials": "RN", "orcid": "0000-0002-6589-2535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1b0dbf50f5f4bbaafb75643f527f0ca.json"}}, {"family": "Kawala", "given": "Brenda Allen", "initials": "BA"}, {"family": "Katairo", "given": "Thomas", "initials": "T", "orcid": "0000-0002-2002-8911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6711071ed8b0441d94f931c7ae884683.json"}}, {"family": "Okullo", "given": "Allen Eva", "initials": "AE"}, {"family": "Apunyo", "given": "Robert", "initials": "R"}, {"family": "Semakula", "given": "Daniel", "initials": "D", "orcid": "0000-0002-0806-213X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ed9d8d3a7aa44ad8443b2310f58fbd7.json"}}, {"family": "Luwambo", "given": "Ash", "initials": "A"}, {"family": "Kinengyere", "given": "Alison Annet", "initials": "AA"}, {"family": "Sewankambo", "given": "Nelson", "initials": "N"}, {"family": "Balinda", "given": "Sheila N", "initials": "SN"}, {"family": "Ocan", "given": "Moses", "initials": "M", "orcid": "0000-0002-8852-820X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de5a2ad5cc524e91851f35ea9ff821b3.json"}}, {"family": "Obuku", "given": "Ekwaro A", "initials": "EA"}], "type": "journal article", "published": "2021-10-18", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "10", "pages": "e050296", "issn-l": "2044-6055"}, "abstract": "Accurate and affordable laboratory testing is key to timely diagnosis and appropriate management of patients with COVID-19. New laboratory test protocols are released into the market under emergency use authorisation with limited evidence on diagnostic test accuracy. As such, robust evidence on the diagnostic accuracy and the costs of available tests is urgently needed to inform policy and practice especially in resource-limited settings. We aim to determine the diagnostic test accuracy, cost-effectiveness and utility of laboratory test strategies for COVID-19 in low-income and middle-income countries.\n\nThis will be a multistaged, protocol-driven systematic review conducted in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for diagnostic test accuracy studies. We will search for relevant literature in at least six public health databases, including PubMed, Google Scholar, MEDLINE, Scopus, Web of Science and the WHO Global Index Medicus. In addition, we will search Cochrane Library, COVID-END and grey literature databases to identify additional relevant articles before double-screening and abstraction of data. We will conduct a structured narrative and quantitative synthesis of the results guided by the Fryback and Thornbury framework for assessing a diagnostic test. The primary outcome is COVID-19 diagnostic test accuracy. Using the GRADE approach specific to diagnostic accuracy tests, we will appraise the overall quality of evidence and report the results following the original PRISMA statement. The protocol is registered with the International Prospective Register of Systematic Reviews (PROSPERO; https://www.crd.york.ac.uk/prospero/).\n\nEthical review was done by the School of Biomedical Sciences Research Ethics Committee and the Uganda National Council for Science and Technology. The published article will be accessible to policy and decision makers. The findings of this review will guide clinical practice and policy decisions and highlight areas for future research.PROSPERO registration number CRD42020209528.", "doi": "10.1136/bmjopen-2021-050296", "pmid": "34663660", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-050296"}], "notes": [], "created": "2021-10-21T04:58:00.330Z", "modified": "2021-10-21T04:58:09.820Z"}, {"entity": "publication", "iuid": "be07526407fe48d398cc79e1536de2d3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be07526407fe48d398cc79e1536de2d3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be07526407fe48d398cc79e1536de2d3"}}, "title": "Migrant workers occupational health research: an OMEGA-NET working group position paper.", "authors": [{"family": "Aktas", "given": "Emine", "initials": "E", "orcid": "0000-0003-2635-7588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e067735686ea462ead1cbe50348d7c04.json"}}, {"family": "Bergbom", "given": "Barbara", "initials": "B", "orcid": "0000-0002-5245-6419", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18083a7cae13485b94ec1cb2a36ea810.json"}}, {"family": "Godderis", "given": "Lode", "initials": "L", "orcid": "0000-0003-4764-8835", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/639b8bdac78742e9aeebe5b33c6dfedb.json"}}, {"family": "Kreshpaj", "given": "Bertina", "initials": "B", "orcid": "0000-0002-2991-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d89b188538b64d6ca022b92c85cd0cf1.json"}}, {"family": "Marinov", "given": "Mario", "initials": "M"}, {"family": "Mates", "given": "Dana", "initials": "D"}, {"family": "McElvenny", "given": "Damien M", "initials": "DM", "orcid": "0000-0003-0953-8336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ffabe7c996ff4f47af509448b20dff49.json"}}, {"family": "Mehlum", "given": "Ingrid Sivesind", "initials": "IS", "orcid": "0000-0003-0830-284X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2366026a9d564a11b0bac13f7a8d3115.json"}}, {"family": "Milenkova", "given": "Valentina", "initials": "V"}, {"family": "Nena", "given": "Evangelia", "initials": "E", "orcid": "0000-0003-0381-4715", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d0b80af9262c45bbaff8afbefc515733.json"}}, {"family": "Glass", "given": "Deborah C", "initials": "DC", "orcid": "0000-0002-7559-008X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1185128471f4cc090044359d8df3b5d.json"}}], "type": "journal article", "published": "2021-10-18", "journal": {"title": "Int Arch Occup Environ Health", "issn": "1432-1246", "issn-l": null}, "abstract": "The aims of the study were: (1) to clarify the definitions of \"migrant\" used in occupational health research; (2) to summarize migrant workers' industry sectors, occupations and employment conditions; (3) to identify the occupational health and safety services available to migrant workers; (4) to summarize work-related health problems found among migrant workers; (5) to identify the methodological challenges to research into occupational health of migrant workers; and (6) to recommend improvements in migrant occupational health research.\n\nThis position paper was prepared by researchers from several European countries and Australia, working within the EU COST Action OMEGA-NET. The paper drew on two recent systematic reviews on the occupational health of international migrant workers and other literature, and also identified uncertainties and gaps in the research literature. Migrants may, for example, be temporary or permanent, moving for specific jobs migrants or other reasons. Their ethnicity and language capabilities will affect their work opportunities.\n\nThe occupational health literature seldom adequately identifies the heterogeneity or characteristics of the migrant group being studied. Migrants tend to work in more physically and mentally demanding environments with higher exposures than native workers. Migrants tend to have an increased risk of physical and mental ill health, but less access to health care services. This has been demonstrated recently by high rates of COVID-19 and less access to health care. There have been a number of cross-sectional studies of migrant health but few long-term cohort studies were identified. Other study designs, such as registry-based studies, surveys and qualitative studies may complement cross-sectional studies. Mixed-methodology studies would be valuable in research on migrants' occupational health. Language and lack of trust are barriers to migrant research participation.\n\nTargeted research, especially longitudinal, identifying how these economically important but often-vulnerable workers can be best assisted is needed. Researchers should identify the characteristics of the migrant workers that they are studying including visa/migration circumstances (temporary, permanent, undocumented), racial and ethnic characteristics, existing skills and language abilities.", "doi": "10.1007/s00420-021-01803-x", "pmid": "34661721", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00420-021-01803-x"}], "notes": [], "created": "2021-10-21T04:59:08.484Z", "modified": "2021-10-21T04:59:08.786Z"}, {"entity": "publication", "iuid": "d1e27ffd876749519ad5c92de8ceb231", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1e27ffd876749519ad5c92de8ceb231.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1e27ffd876749519ad5c92de8ceb231"}}, "title": "How the COVID-19 pandemic affects transgender health care - A cross-sectional online survey in 63 upper-middle-income and high-income countries.", "authors": [{"family": "Koehler", "given": "Andreas", "initials": "A", "orcid": "0000-0003-0415-3007", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6f71cad12f54442b7c37a3ca124148b.json"}}, {"family": "Motmans", "given": "Joz", "initials": "J", "orcid": "0000-0001-7643-4153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e84b4ee717654f5d9e0c102cb396a249.json"}}, {"family": "Muli\u00f3 Alvarez", "given": "Leo", "initials": "L"}, {"family": "Azul", "given": "David", "initials": "D", "orcid": "0000-0002-9181-8582", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/843fa6d772084e38a549235a1c80cc75.json"}}, {"family": "Badalyan", "given": "Karen", "initials": "K"}, {"family": "Basar", "given": "Koray", "initials": "K"}, {"family": "Dhejne", "given": "Cecilia", "initials": "C"}, {"family": "Dui\u0161in", "given": "Dragana", "initials": "D"}, {"family": "Grabski", "given": "Bartosz", "initials": "B", "orcid": "0000-0002-6268-2647", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c02c6d9cc5ff44729bb5e1bbc1be6151.json"}}, {"family": "Dufrasne", "given": "Aurore", "initials": "A"}, {"family": "Jokic-Begic", "given": "Natasa", "initials": "N", "orcid": "0000-0003-2597-535X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9bb577af0fc44464a6937b22d3c71524.json"}}, {"family": "Prunas", "given": "Antonio", "initials": "A"}, {"family": "Richards", "given": "Christina", "initials": "C"}, {"family": "Sabir", "given": "Kirill", "initials": "K"}, {"family": "Veale", "given": "Jaimie", "initials": "J"}, {"family": "Nieder", "given": "Timo Ole", "initials": "TO", "orcid": "0000-0003-3052-5169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a8f6f000cf144a293658031d5ff9ba4.json"}}], "type": "journal article", "published": "2021-10-18", "journal": {"title": "Int J Transgend Health", "issn": "2689-5277", "issn-l": null, "volume": "24", "issue": "3", "pages": "346-359"}, "abstract": "Due to the COVID-19 pandemic, access to medical care is restricted for nearly all non-acute conditions. Due to their status as a vulnerable social group and the inherent need for transition-related treatments, transgender people are assumed to be affected particularly severely by the restrictions caused by the COVID-19 pandemic.\r\n\r\nAs an ad hoc collaboration between researchers, clinicians and 23 community organizations, we developed a web-based survey in German that was translated into 26 languages. Participants were recruited via community sources, social media channels, and snowball sampling since May 2020. The present sample is based on the data collected until August 9, 2020. We assessed demographical data, health problems, risk factors, COVID-19 data (e.g., contact history), and the influence of the COVID-19 pandemic on access to transgender health care services. To identify factors associated with the experience of restrictions, we conducted multiple logistic regression analysis.\r\n\r\n5267 transgender people from 63 upper-middle-income and high-income countries participated in the study. Over 50% of the participants had risk factors for a severe course of a COVID-19 infection and were at a high risk of avoiding COVID-19 treatment due to the fear of mistreatment or discrimination. Access to transgender health care services was restricted for 50% of the participants. Male sex assigned at birth and a lower monthly income were significant predictors for the experience of restrictions to health care. 35.0% reported at least one mental health condition and 3.2% have attempted suicide since the beginning of the COVID-19 pandemic.\r\n\r\nTransgender people suffer under the severity of the pandemic due to the intersections between their status as a vulnerable social group, their high number of medical risk factors, and their need for ongoing medical treatment. The COVID-19 pandemic can potentiate these vulnerabilities, add new challenges for transgender people, and, therefore, can lead to devastating consequences, like severe physical or mental health issues, self-harming behavior, and suicidality.", "doi": "10.1080/26895269.2021.1986191", "pmid": "37519919", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10373616"}, {"db": "pii", "key": "1986191"}], "notes": [], "created": "2023-10-04T12:12:44.096Z", "modified": "2023-10-04T13:33:45.009Z"}, {"entity": "publication", "iuid": "0d9c8a32320f4f6981c3a502a9fee2db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d9c8a32320f4f6981c3a502a9fee2db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d9c8a32320f4f6981c3a502a9fee2db"}}, "title": "Effectiveness of heterologous ChAdOx1 nCoV-19 and mRNA prime-boost vaccination against symptomatic Covid-19 infection in Sweden: A nationwide cohort study.", "authors": [{"family": "Nordstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Ballin", "given": "Marcel", "initials": "M"}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-10-18", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "issn-l": null, "volume": null, "issue": null, "pages": "100249"}, "abstract": "The effectiveness of heterologous prime-boost Coronavirus disease 2019 (Covid-19) vaccination is currently unknown.\r\n\r\nFrom individuals vaccinated with two doses against Covid-19 in Sweden until July 5, 2021 (N=3,445,061), we formed a study cohort including 94,569 individuals that had received heterologous ChAdOx1 nCoV-19 / BNT162b2 prime-boost vaccination, 16,402 individuals that received heterologous ChAdOx1 nCoV-19 / mRNA-1273 prime-boost vaccination, and 430,100 individuals that received homologous ChAdOx1 nCoV-19 / ChAdOx1 nCoV-19 prime-boost vaccination. In addition, 180,716 individuals were selected who were unvaccinated at the date of vaccination in the corresponding case. Unvaccinated individuals were censored at first dose of any vaccine. Baseline was the date of the second dose of any vaccine, with the same date in the corresponding unvaccinated individual. The outcome included incident symptomatic Covid-19 infection occurring >14 days after baseline.\r\n\r\nDuring a mean follow-up time of 76 (range 1-183) days, symptomatic Covid-19 infection was confirmed in 187 individuals with heterologous vaccine schedules (incidence rate: 2.0/100,000 person-days) and in 306 individuals from the unvaccinated control group (incidence rate: 7.1/100,000 person-days). The adjusted vaccine effectiveness was 67% (95% CI, 59-73, P<0.001) for heterologous ChAdOx1 nCoV-19 / BNT162b2 prime-boost vaccination, and 79% (95% CI, 62-88, P<0.001) for heterologous ChAdOx1 nCoV-19 / mRNA-1273 prime-boost vaccination. When combined and analysed together, the two heterologous vaccine schedules had an effectiveness of 68% (95% CI, 61-74, P<0.001) which was significantly greater (Pinteraction<0.001) than the 50% effectiveness for homologous ChAdOx1 nCoV-19 / ChAdOx1 nCoV-19 (95% CI, 41-58, P<0.001).\r\n\r\nThe findings of this study suggest that the use of heterologous ChAdOx1 nCoV-19 and mRNA prime-boost vaccination is an effective alternative to increase population immunity against Covid-19, including against the Delta variant which dominated the confirmed cases during the study period. These findings could have important implications for vaccination strategies and logistics, and consequently in the battle against the Covid-19 pandemic.", "doi": "10.1016/j.lanepe.2021.100249", "pmid": "34693387", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00235-0"}, {"db": "pmc", "key": "PMC8520818"}], "notes": [], "created": "2021-10-26T18:25:41.189Z", "modified": "2021-12-07T15:23:48.364Z"}, {"entity": "publication", "iuid": "2f8b9fb8a6854364a925caae0ef582ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2f8b9fb8a6854364a925caae0ef582ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2f8b9fb8a6854364a925caae0ef582ee"}}, "title": "Pregnancy and risk of COVID-19: a Norwegian registry-linkage study.", "authors": [{"family": "Magnus", "given": "Maria C", "initials": "MC", "orcid": "0000-0002-0568-3774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3530918cfd534021a45a80628c89c580.json"}}, {"family": "Oakley", "given": "Laura", "initials": "L"}, {"family": "Gjessing", "given": "H\u00e5kon K", "initials": "HK"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}, {"family": "Engjom", "given": "Hilde M", "initials": "HM"}, {"family": "Macsali", "given": "Ferenc", "initials": "F"}, {"family": "Juliusson", "given": "Petur B", "initials": "PB"}, {"family": "Andersen", "given": "Anne-Marie Nybo", "initials": "AN"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}], "type": "journal article", "published": "2021-10-17", "journal": {"title": "BJOG", "issn": "1471-0528", "issn-l": null}, "abstract": "To compare the risk of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and contact with specialist health-care services for coronavirus disease 2019 (COVID-19) between pregnant and non-pregnant women.\n\nAll women ages 15 to 45 living in Norway on March 1st , 2020 (N=1,033,699).\n\nWe linked information from the national birth, patient, communicable diseases, and education databases using unique national identifiers.\n\nWe estimated hazard ratios (HR) among pregnant compared to non-pregnant women of having a positive test for SARS-CoV-2, a diagnosis of COVID-19 in specialist healthcare, or hospitalization with COVID-19 using Cox regression. Multivariable analyses adjusted for age, marital status, education, income, country of birth and underlying medical conditions.\n\nPregnant women were not more likely to be tested for or to a have a positive SARS-CoV-2 test (adjusted HR, 0.99; 95% confidence interval [CI]: 0.92-1.07). Pregnant women had higher risk of hospitalization with COVID-19 (HR, 4.70; 95% CI: 3.51- 6.30), and any type of specialist care for COVID-19 (HR, 3.46; 95% CI: 2.89-4.14). Pregnant women born outside Scandinavia were less likely to be tested, and at higher risk of a positive test (HR, 2.37; 95% CI: 2.51-8.87). Compared to pregnant Scandinavian born women, pregnant women with minority background had a higher risk of hospitalization with COVID-19 (HR, 4.72; 95% CI: 2.51-8.87).\n\nPregnant women were not more likely to be infected with SARS-CoV-2. Still, pregnant women with COVID-19, especially those born outside of Scandinavia, were more likely to be hospitalized.", "doi": "10.1111/1471-0528.16969", "pmid": "34657368", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-21T05:02:48.784Z", "modified": "2021-10-21T05:02:48.838Z"}, {"entity": "publication", "iuid": "d68837621db0417dbb9ba64eeaebde42", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d68837621db0417dbb9ba64eeaebde42.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d68837621db0417dbb9ba64eeaebde42"}}, "title": "Cross-cultural prevalence of sleep quality and psychological distress in healthcare workers during COVID-19 pandemic.", "authors": [{"family": "Khan", "given": "Hamza Rafique", "initials": "HR", "orcid": "0000-0002-5914-1444", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd107a2d49c84125bd829a8e32a63af8.json"}}, {"family": "Ashraf", "given": "Farzana", "initials": "F", "orcid": "0000-0003-0110-2618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b5ea851706e4435a5a749b8f25b0147.json"}}, {"family": "Ullah", "given": "Irfan", "initials": "I", "orcid": "0000-0003-1100-101X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8d5a7e15ae6487cbdda0de3b2a531c3.json"}}, {"family": "Tahir", "given": "Muhammad Junaid", "initials": "MJ", "orcid": "0000-0002-0335-6681", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3192523e30b47e4ba6579ed8ab36661.json"}}, {"family": "Dominari", "given": "Asimina", "initials": "A", "orcid": "0000-0002-4023-9767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a082d5a6c7f64a0a982b53edcb22d2d1.json"}}, {"family": "Shoib", "given": "Sheikh", "initials": "S"}, {"family": "Naeem", "given": "Hamna", "initials": "H", "orcid": "0000-0002-3271-9250", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1dba9d91b94e487f84eec592237b73eb.json"}}, {"family": "Reddy", "given": "Gowry", "initials": "G", "orcid": "0000-0003-0774-5809", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5651795d3353483092a191cf52d094b3.json"}}, {"family": "Mukherjee", "given": "Pramit", "initials": "P", "orcid": "0000-0002-8717-2395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a287ee82a04449d8d82230ad0c94fa0.json"}}, {"family": "Akram", "given": "Ifrah", "initials": "I", "orcid": "0000-0002-2737-3224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/983eaa0b255b454b946dda58b4786c04.json"}}, {"family": "Kamada", "given": "Sudha", "initials": "S", "orcid": "0000-0001-8332-8973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/095f77b1995148b5819f6a1c0e14acbb.json"}}, {"family": "Memon", "given": "Roshni Riaz", "initials": "RR", "orcid": "0000-0003-2410-2055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79c76ba9210341538cbcf2a5e0ef30b1.json"}}, {"family": "Khan", "given": "M Muzzamil Yasin", "initials": "MMY"}, {"family": "Raut", "given": "Sumit", "initials": "S", "orcid": "0000-0001-6090-8027", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9d431cfd57548979e61ff7287da4551.json"}}, {"family": "Shalaby", "given": "Mahmoud Mohamed Mohamed", "initials": "MMM", "orcid": "0000-0001-7237-4616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51ae61a95e0243438b5603032c6bc49b.json"}}, {"family": "Anwar", "given": "Rana Usman", "initials": "RU", "orcid": "0000-0002-7874-3870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2be3d1deeb044679da6f7738f399087.json"}}, {"family": "Farooq", "given": "Maheen", "initials": "M", "orcid": "0000-0001-5084-8614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64e7d11516d400a91a9ee939f984b49.json"}}, {"family": "Soparia", "given": "Krupa Ketankumar", "initials": "KK", "orcid": "0000-0002-0711-5826", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae4d64ac01bc4241a25a27dd4c9dc77e.json"}}, {"family": "Ramalho", "given": "Rodrigo", "initials": "R", "orcid": "0000-0002-2372-6854", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b990d3c278047a9b3878d47316ea4ed.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-10-17", "journal": {"title": "Brain Behav", "issn": "2162-3279", "pages": "e2383", "issn-l": null}, "abstract": "Poor quality sleep and emotional disturbances are expected in times of crisis. COVID-19 has severely impacted healthcare worldwide and with that comes the concern about its effects on healthcare workers. The purpose of the present study was to assess sleep quality and psychological distress in healthcare workers during the COVID-19 pandemic.\n\nThe present work is a multi-centric cross-sectional study targeting healthcare workers from India, Pakistan, and Nepal. It used an online version of the Pittsburg Sleep Quality Index and the General Health Questionnaire, and data were analyzed using SPSS V.24.\n\nA total of 1790 participants completed the questionnaire. Of the 1790 participants, 57% reported poor sleep quality, and 10% reported a high level of psychological distress. A cross-cultural comparison found some differences between the different groups of participants. The details of the differences were further explored in the article.\n\nThe present study highlights that a significant proportion of healthcare workers are affected by poor sleep quality and psychological distress during the COVID-19 pandemic. It also emphasizes the imperative to provide them with psychosocial support to avoid potential short- and long-term psychological consequences of these troubling times.", "doi": "10.1002/brb3.2383", "pmid": "34661987", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-10-21T04:58:34.375Z", "modified": "2021-10-21T04:58:34.863Z"}, {"entity": "publication", "iuid": "ea26f82200d843c39406150be734c4b7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ea26f82200d843c39406150be734c4b7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ea26f82200d843c39406150be734c4b7"}}, "title": "Robotic-Based Well-Being Monitoring and Coaching System for the Elderly in Their Daily Activities", "authors": [{"family": "Calatrava-Nicol\u00e1s", "given": "Francisco M", "initials": "FM", "orcid": "0000-0001-6647-4215", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37ad41c6253a489c809900830c616348.json"}}, {"family": "Guti\u00e9rrez-Maestro", "given": "Eduardo", "initials": "E"}, {"family": "Bautista-Salinas", "given": "Daniel", "initials": "D", "orcid": "0000-0001-5318-952X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef0d6dafcd324c9eb0cad123179d7639.json"}}, {"family": "Ortiz", "given": "Francisco J", "initials": "FJ", "orcid": "0000-0002-2294-688X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10dde443cdb44d008b36eb5d1073d549.json"}}, {"family": "Gonz\u00e1lez", "given": "Joaqu\u00edn Roca", "initials": "JR"}, {"family": "Vera-Repullo", "given": "Jos\u00e9 Alfonso", "initials": "JA"}, {"family": "Jim\u00e9nez-Buend\u00eda", "given": "Manuel", "initials": "M", "orcid": "0000-0002-6092-1974", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67e238cdac5440b7936dba299312872c.json"}}, {"family": "M\u00e9ndez", "given": "Inmaculada", "initials": "I", "orcid": "0000-0001-8458-5314", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e971819fe8a447828199a0f987619383.json"}}, {"family": "Ruiz-Esteban", "given": "Cecilia", "initials": "C", "orcid": "0000-0002-5836-331X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae5cc8fc2ffe4cf384eab19408c21624.json"}}, {"family": "Mozos", "given": "Oscar Mart\u00ednez", "initials": "OM"}], "type": "journal-article", "published": "2021-10-16", "journal": {"title": "Sensors (Basel)", "issn": "1424-8220", "issn-l": null, "volume": "21", "issue": "20", "pages": "6865"}, "abstract": null, "doi": "10.3390/s21206865", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:29:19.094Z", "modified": "2022-02-17T11:44:28.465Z"}, {"entity": "publication", "iuid": "b96c3e80cf1140bc8be296eb4d99e995", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b96c3e80cf1140bc8be296eb4d99e995.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b96c3e80cf1140bc8be296eb4d99e995"}}, "title": "Correspondence regarding \"Delay to elective colorectal cancer surgery and implications for survival: a systematic review and meta-analysis\".", "authors": [{"family": "Onerup", "given": "Aron", "initials": "A"}, {"family": "Rydbeck", "given": "Daniel", "initials": "D"}, {"family": "Bock", "given": "David", "initials": "D"}, {"family": "Haglind", "given": "Eva", "initials": "E"}, {"family": "Angenete", "given": "Eva", "initials": "E", "orcid": "0000-0001-9966-4904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/473b9940a9f34e379796200d3769cbf6.json"}}], "type": "letter", "published": "2021-10-16", "journal": {"title": "Colorectal Dis", "issn": "1463-1318", "issn-l": null}, "abstract": "We read with interest the article by Whittaker et al [1]. We believe that the research question is of importance both in light of delayed treatment during the COVID-19 pandemic and in light of recent results where preoperative lifestyle changes only seem to be effective when performed for at least six weeks [2, 3]. However, we have some questions regarding the methodology and conclusions from the study.", "doi": "10.1111/codi.15957", "pmid": "34655446", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-21T05:04:00.437Z", "modified": "2021-10-21T05:04:00.515Z"}, {"entity": "publication", "iuid": "c02bff9bce9740ffb1887af7a9a305ec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c02bff9bce9740ffb1887af7a9a305ec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c02bff9bce9740ffb1887af7a9a305ec"}}, "title": "Bacterial contamination of the smartphones of healthcare workers in a German tertiary-care hospital before and during the COVID-19 pandemic.", "authors": [{"family": "Tannh\u00e4user", "given": "Romy", "initials": "R"}, {"family": "Nickel", "given": "Olaf", "initials": "O"}, {"family": "Lindner", "given": "Margareta", "initials": "M"}, {"family": "Bethge", "given": "Angela", "initials": "A"}, {"family": "Wolf", "given": "Johannes", "initials": "J"}, {"family": "Borte", "given": "Stephan", "initials": "S"}, {"family": "L\u00fcbbert", "given": "Christoph", "initials": "C"}], "type": "journal article", "published": "2021-10-16", "journal": {"title": "Am J Infect Control", "issn": "1527-3296", "issn-l": null}, "abstract": "Assuming that hygiene measures have improved significantly due to COVID-19, we aimed to investigate bacterial colonization on smartphones (SPs) owned by healthcare workers (HCWs) before and during the pandemic.\n\nEmploying a before-and-after study design, randomly selected HCWs were included. Devices underwent sampling under real-life conditions, without prior manipulation. Swabs were collected in 2012 (pre-pandemic) and 2021 to determine microbial colonization. Isolates were identified by MALDI-TOF mass spectrometry and underwent microbiological susceptibility testing.\n\nThe final analysis included 295 HCWs (67% female, mean age 34 years) from 26 wards. Bacterial contamination was present on 293 of 295 SP screens (99.3%). The proportion of clinically relevant bacterial pathogens (e.g. Staphylococcus aureus, enterococci, Enterobacterales, non-fermenting bacteria) ranged from 21.2% in 2012 to 39.8% in 2021. Resistance profiles revealed a proportion of multidrug-resistant bacteria such as MRSA and VRE of less than 2%. The comparison of before-and-after sampling showed a significant increase in smartphone use during work from 2012 to 2021 with a simultaneous increase in cleaning intensity, probably as a result of the COVID-19 pandemic.\n\nBacterial contamination of SPs within the hospital is of concern and can serve as a source of cross-contamination. Hence, SPs must be carefully disinfected after handling in healthcare. Behavioral changes related to the COVID-19 pandemic could have a significant impact if implemented sustainably in everyday clinical practice.", "doi": "10.1016/j.ajic.2021.09.025", "pmid": "34666129", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0196-6553(21)00669-6"}], "notes": [], "created": "2021-10-21T04:50:10.433Z", "modified": "2021-10-21T04:50:10.470Z"}, {"entity": "publication", "iuid": "fda0d68c9682442b9ea60df82cad31e6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fda0d68c9682442b9ea60df82cad31e6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fda0d68c9682442b9ea60df82cad31e6"}}, "title": "Self-reported impact of the COVID-19 pandemic, affective responding, and subjective well-being: A Swedish survey.", "authors": [{"family": "Gr\u00f6ndal", "given": "Maria", "initials": "M", "orcid": "0000-0002-1108-249X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/710a6d6cf4de46eb9ae1b2e4837dc67c.json"}}, {"family": "Ask", "given": "Karl", "initials": "K", "orcid": "0000-0001-5093-5902", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec311e51b22d445f98839bf046ab4637.json"}}, {"family": "Luke", "given": "Timothy J", "initials": "TJ", "orcid": "0000-0002-5513-6605", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d790d0984ed42b6afa6f8649e74e836.json"}}, {"family": "Winblad", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2021-10-15", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0258778", "issn-l": "1932-6203"}, "abstract": "A rapid stream of research confirms that the COVID-19 pandemic is a global threat to mental health and psychological well-being. It is therefore important to identify both hazardous and protective individual factors during the pandemic. The current research explored the relationships between self-reported affective responding, perceived personal consequences of the COVID-19 pandemic, and subjective well-being. An online survey (N = 471) conducted in Sweden between June and September, 2020, showed that higher levels of irritability, impulsivity, and the tendency to experience and express anger were generally associated with more severe personal consequences of the pandemic, particularly in areas related to family life, work/study, and finances. While more severe impacts of the pandemic in these areas of life were directly associated with lower subjective well-being, emotion regulation through cognitive reappraisal appeared to moderate the extent to which consequences of the pandemic in other areas of life (i.e., social, free-time and physical activities) translated into decreased well-being. This suggests that cognitive reappraisal may serve to protect against some of the debilitating effects of the COVID-19 pandemic on mental health. Overall, the results indicate that the perceived consequences of the pandemic are multifaceted and that future research should examine these consequences using a multidimensional approach.", "doi": "10.1371/journal.pone.0258778", "pmid": "34653222", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-05122"}], "notes": [], "created": "2021-10-21T05:04:57.088Z", "modified": "2021-10-21T05:04:57.216Z"}, {"entity": "publication", "iuid": "16f513d95162469b87c66881775a8960", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16f513d95162469b87c66881775a8960.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16f513d95162469b87c66881775a8960"}}, "title": "Results of the COVID-19 mental health international for the general population (COMET-G) study.", "authors": [{"family": "Fountoulakis", "given": "Konstantinos N", "initials": "KN"}, {"family": "Karakatsoulis", "given": "Grigorios", "initials": "G"}, {"family": "Abraham", "given": "Seri", "initials": "S"}, {"family": "Adorjan", "given": "Kristina", "initials": "K"}, {"family": "Ahmed", "given": "Helal Uddin", "initials": "HU"}, {"family": "Alarc\u00f3n", "given": "Renato D", "initials": "RD"}, {"family": "Arai", "given": "Kiyomi", "initials": "K"}, {"family": "Auwal", "given": "Sani Salihu", "initials": "SS"}, {"family": "Berk", "given": "Michael", "initials": "M"}, {"family": "Bjedov", "given": "Sarah", "initials": "S"}, {"family": "Bobes", "given": "Julio", "initials": "J"}, {"family": "Bobes-Bascaran", "given": "Teresa", "initials": "T"}, {"family": "Bourgin-Duchesnay", "given": "Julie", "initials": "J"}, {"family": "Bredicean", "given": "Cristina Ana", "initials": "CA"}, {"family": "Bukelskis", "given": "Laurynas", "initials": "L"}, {"family": "Burkadze", "given": "Akaki", "initials": "A"}, {"family": "Abud", "given": "Indira Indiana Cabrera", "initials": "IIC"}, {"family": "Castilla-Puentes", "given": "Ruby", "initials": "R"}, {"family": "Cetkovich", "given": "Marcelo", "initials": "M"}, {"family": "Colon-Rivera", "given": "Hector", "initials": "H"}, {"family": "Corral", "given": "Ricardo", "initials": "R"}, {"family": "Cortez-Vergara", "given": "Carla", "initials": "C"}, {"family": "Crepin", "given": "Piirika", "initials": "P"}, {"family": "De Berardis", "given": "Domenico", "initials": "D"}, {"family": "Zamora Delgado", "given": "Sergio", "initials": "S"}, {"family": "De Lucena", "given": "David", "initials": "D"}, {"family": "De Sousa", "given": "Avinash", "initials": "A"}, {"family": "Stefano", "given": "Ramona Di", "initials": "RD"}, {"family": "Dodd", "given": "Seetal", "initials": "S"}, {"family": "Elek", "given": "Livia Priyanka", "initials": "LP"}, {"family": "Elissa", "given": "Anna", "initials": "A"}, {"family": "Erdelyi-Hamza", "given": "Berta", "initials": "B"}, {"family": "Erzin", "given": "Gamze", "initials": "G"}, {"family": "Etchevers", "given": "Martin J", "initials": "MJ"}, {"family": "Falkai", "given": "Peter", "initials": "P"}, {"family": "Farcas", "given": "Adriana", "initials": "A"}, {"family": "Fedotov", "given": "Ilya", "initials": "I"}, {"family": "Filatova", "given": "Viktoriia", "initials": "V"}, {"family": "Fountoulakis", "given": "Nikolaos K", "initials": "NK"}, {"family": "Frankova", "given": "Iryna", "initials": "I"}, {"family": "Franza", "given": "Francesco", "initials": "F"}, {"family": "Frias", "given": "Pedro", "initials": "P"}, {"family": "Galako", "given": "Tatiana", "initials": "T"}, {"family": "Garay", "given": "Cristian J", "initials": "CJ"}, {"family": "Garcia-\u00c1lvarez", "given": "Leticia", "initials": "L"}, {"family": "Garc\u00eda-Portilla", "given": "Maria Paz", "initials": "MP"}, {"family": "Gonda", "given": "Xenia", "initials": "X"}, {"family": "Gondek", "given": "Tomasz M", "initials": "TM"}, {"family": "Gonz\u00e1lez", "given": "Daniela Morera", "initials": "DM"}, {"family": "Gould", "given": "Hilary", "initials": "H"}, {"family": "Grandinetti", "given": "Paolo", "initials": "P"}, {"family": "Grau", "given": "Arturo", "initials": "A"}, {"family": "Groudeva", "given": "Violeta", "initials": "V"}, {"family": "Hagin", "given": "Michal", "initials": "M"}, {"family": "Harada", "given": "Takayuki", "initials": "T"}, {"family": "Hasan", "given": "Tasdik M", "initials": "TM"}, {"family": "Hashim", "given": "Nurul Azreen", "initials": "NA"}, {"family": "Hilbig", "given": "Jan", "initials": "J"}, {"family": "Hossain", "given": "Sahadat", "initials": "S"}, {"family": "Iakimova", "given": "Rossitza", "initials": "R"}, {"family": "Ibrahim", "given": "Mona", "initials": "M"}, {"family": "Iftene", "given": "Felicia", "initials": "F"}, {"family": "Ignatenko", "given": "Yulia", "initials": "Y"}, {"family": "Irarrazaval", "given": "Matias", "initials": "M"}, {"family": "Ismail", "given": "Zaliha", "initials": "Z"}, {"family": "Ismayilova", "given": "Jamila", "initials": "J"}, {"family": "Jakobs", "given": "Asaf", "initials": "A"}, {"family": "Jakovljevi\u0107", "given": "Miro", "initials": "M"}, {"family": "Jak\u0161i\u0107", "given": "Nenad", "initials": "N"}, {"family": "Javed", "given": "Afzal", "initials": "A"}, {"family": "Kafali", "given": "Helin Yilmaz", "initials": "HY"}, {"family": "Karia", "given": "Sagar", "initials": "S"}, {"family": "Kazakova", "given": "Olga", "initials": "O"}, {"family": "Khalifa", "given": "Doaa", "initials": "D"}, {"family": "Khaustova", "given": "Olena", "initials": "O"}, {"family": "Koh", "given": "Steve", "initials": "S"}, {"family": "Kopishinskaia", "given": "Svetlana", "initials": "S"}, {"family": "Kosenko", "given": "Korneliia", "initials": "K"}, {"family": "Koupidis", "given": "Sotirios A", "initials": "SA"}, {"family": "Kovacs", "given": "Illes", "initials": "I"}, {"family": "Kulig", "given": "Barbara", "initials": "B"}, {"family": "Lalljee", "given": "Alisha", "initials": "A"}, {"family": "Liewig", "given": "Justine", "initials": "J"}, {"family": "Majid", "given": "Abdul", "initials": "A"}, {"family": "Malashonkova", "given": "Evgeniia", "initials": "E"}, {"family": "Malik", "given": "Khamelia", "initials": "K"}, {"family": "Malik", "given": "Najma Iqbal", "initials": "NI"}, {"family": "Mammadzada", "given": "Gulay", "initials": "G"}, {"family": "Mandalia", "given": "Bilvesh", "initials": "B"}, {"family": "Marazziti", "given": "Donatella", "initials": "D"}, {"family": "Mar\u010dinko", "given": "Darko", "initials": "D"}, {"family": "Martinez", "given": "Stephanie", "initials": "S"}, {"family": "Matiekus", "given": "Eimantas", "initials": "E"}, {"family": "Mejia", "given": "Gabriela", "initials": "G"}, {"family": "Memon", "given": "Roha Saeed", "initials": "RS"}, {"family": "Mart\u00ednez", "given": "Xarah Elenne Meza", "initials": "XEM"}, {"family": "Mickevi\u010di\u016bt\u0117", "given": "Dalia", "initials": "D"}, {"family": "Milev", "given": "Roumen", "initials": "R"}, {"family": "Mohammed", "given": "Muftau", "initials": "M"}, {"family": "Molina-L\u00f3pez", "given": "Alejandro", "initials": "A"}, {"family": "Morozov", "given": "Petr", "initials": "P"}, {"family": "Muhammad", "given": "Nuru Suleiman", "initials": "NS"}, {"family": "Musta\u010d", "given": "Filip", "initials": "F"}, {"family": "Naor", "given": "Mika S", "initials": "MS"}, {"family": "Nassieb", "given": "Amira", "initials": "A"}, {"family": "Navickas", "given": "Alvydas", "initials": "A"}, {"family": "Okasha", "given": "Tarek", "initials": "T"}, {"family": "Pandova", "given": "Milena", "initials": "M"}, {"family": "Panfil", "given": "Anca-Livia", "initials": "AL"}, {"family": "Panteleeva", "given": "Liliya", "initials": "L"}, {"family": "Papava", "given": "Ion", "initials": "I"}, {"family": "Patsali", "given": "Mikaella E", "initials": "ME"}, {"family": "Pavlichenko", "given": "Alexey", "initials": "A"}, {"family": "Pejuskovic", "given": "Bojana", "initials": "B"}, {"family": "Pinto Da Costa", "given": "Mariana", "initials": "M"}, {"family": "Popkov", "given": "Mikhail", "initials": "M"}, {"family": "Popovic", "given": "Dina", "initials": "D"}, {"family": "Raduan", "given": "Nor Jannah Nasution", "initials": "NJN"}, {"family": "Ram\u00edrez", "given": "Francisca Vargas", "initials": "FV"}, {"family": "Rancans", "given": "Elmars", "initials": "E"}, {"family": "Razali", "given": "Salmi", "initials": "S"}, {"family": "Rebok", "given": "Federico", "initials": "F"}, {"family": "Rewekant", "given": "Anna", "initials": "A"}, {"family": "Flores", "given": "Elena Ninoska Reyes", "initials": "ENR"}, {"family": "Rivera-Encinas", "given": "Mar\u00eda Teresa", "initials": "MT"}, {"family": "Saiz", "given": "Pilar", "initials": "P"}, {"family": "de Carmona", "given": "Manuel S\u00e1nchez", "initials": "MS"}, {"family": "Mart\u00ednez", "given": "David Saucedo", "initials": "DS"}, {"family": "Saw", "given": "Jo Anne", "initials": "JA"}, {"family": "Saygili", "given": "G\u00f6rkem", "initials": "G"}, {"family": "Schneidereit", "given": "Patricia", "initials": "P"}, {"family": "Shah", "given": "Bhumika", "initials": "B"}, {"family": "Shirasaka", "given": "Tomohiro", "initials": "T"}, {"family": "Silagadze", "given": "Ketevan", "initials": "K"}, {"family": "Sitanggang", "given": "Satti", "initials": "S"}, {"family": "Skugarevsky", "given": "Oleg", "initials": "O"}, {"family": "Spikina", "given": "Anna", "initials": "A"}, {"family": "Mahalingappa", "given": "Sridevi Sira", "initials": "SS"}, {"family": "Stoyanova", "given": "Maria", "initials": "M"}, {"family": "Szczegielniak", "given": "Anna", "initials": "A"}, {"family": "Tamasan", "given": "Simona Claudia", "initials": "SC"}, {"family": "Tavormina", "given": "Giuseppe", "initials": "G"}, {"family": "Tavormina", "given": "Maurilio Giuseppe Maria", "initials": "MGM"}, {"family": "Theodorakis", "given": "Pavlos N", "initials": "PN"}, {"family": "Tohen", "given": "Mauricio", "initials": "M"}, {"family": "Tsapakis", "given": "Eva Maria", "initials": "EM"}, {"family": "Tukhvatullina", "given": "Dina", "initials": "D"}, {"family": "Ullah", "given": "Irfan", "initials": "I"}, {"family": "Vaidya", "given": "Ratnaraj", "initials": "R"}, {"family": "Vega-Dienstmaier", "given": "Johann M", "initials": "JM"}, {"family": "Vrublevska", "given": "Jelena", "initials": "J"}, {"family": "Vukovic", "given": "Olivera", "initials": "O"}, {"family": "Vysotska", "given": "Olga", "initials": "O"}, {"family": "Widiasih", "given": "Natalia", "initials": "N"}, {"family": "Yashikhina", "given": "Anna", "initials": "A"}, {"family": "Prezerakos", "given": "Panagiotis E", "initials": "PE"}, {"family": "Smirnova", "given": "Daria", "initials": "D"}], "type": "journal article", "published": "2021-10-15", "journal": {"title": "Eur Neuropsychopharmacol", "issn": "1873-7862", "volume": "54", "pages": "21-40", "issn-l": null}, "abstract": "There are few published empirical data on the effects of COVID-19 on mental health, and until now, there is no large international study.\n\nDuring the COVID-19 pandemic, an online questionnaire gathered data from 55,589 participants from 40 countries (64.85% females aged 35.80 \u00b1 13.61; 34.05% males aged 34.90\u00b113.29 and 1.10% other aged 31.64\u00b113.15). Distress and probable depression were identified with the use of a previously developed cut-off and algorithm respectively.\n\nDescriptive statistics were calculated. Chi-square tests, multiple forward stepwise linear regression analyses and Factorial Analysis of Variance (ANOVA) tested relations among variables.\n\nProbable depression was detected in 17.80% and distress in 16.71%. A significant percentage reported a deterioration in mental state, family dynamics and everyday lifestyle. Persons with a history of mental disorders had higher rates of current depression (31.82% vs. 13.07%). At least half of participants were accepting (at least to a moderate degree) a non-bizarre conspiracy. The highest Relative Risk (RR) to develop depression was associated with history of Bipolar disorder and self-harm/attempts (RR = 5.88). Suicidality was not increased in persons without a history of any mental disorder. Based on these results a model was developed.\n\nThe final model revealed multiple vulnerabilities and an interplay leading from simple anxiety to probable depression and suicidality through distress. This could be of practical utility since many of these factors are modifiable. Future research and interventions should specifically focus on them.", "doi": "10.1016/j.euroneuro.2021.10.004", "pmid": "34758422", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0924-977X(21)00775-6"}, {"db": "pmc", "key": "PMC8609892"}], "notes": [], "created": "2021-11-26T15:22:18.414Z", "modified": "2021-11-26T15:22:18.427Z"}, {"entity": "publication", "iuid": "a8685649f67047399e5093949f457284", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8685649f67047399e5093949f457284.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8685649f67047399e5093949f457284"}}, "title": "Psychometric Testing of the Modified Dental Anxiety Scale among Iranian Adolescents during COVID-19 Pandemic", "authors": [{"family": "Lin", "given": "Chung Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": 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"https://publications-covid19.scilifelab.se/researcher/301b59d7b5074ace866319c0210d60ac.json"}}, {"family": "Tascini", "given": "Carlo", "initials": "C", "orcid": "0000-0001-9625-6024", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea9384b56c654e5ebec3000ee2c4e285.json"}}, {"family": "Miranda-Castillo", "given": "Carolina", "initials": "C", "orcid": "0000-0001-8763-9576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8152e4ccbe9146ab96382e954909b55d.json"}}, {"family": "Khanna", "given": "Nina", "initials": "N", "orcid": "0000-0002-2642-419X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4ea8c9224c44ead9bcf5360e0412cd4.json"}}, {"family": "M\u00e9ndez", "given": "Gustavo-Adolfo", "initials": "GA", "orcid": "0000-0003-0514-7004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed5e3f5f20fd4a40b5780d14663ac211.json"}}, {"family": "Petzer", "given": "Verena", "initials": "V", "orcid": "0000-0002-9205-1440", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b52c652fbe2245d1a3df0ca220d8ad98.json"}}, {"family": "Nov\u00e1k", "given": "Jan", "initials": "J"}, {"family": "Besson", "given": "Caroline", "initials": "C", "orcid": "0000-0003-4364-7173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adc322a60efe4963a3ff76aa00c885d6.json"}}, {"family": "Dul\u00e9ry", "given": "R\u00e9my", "initials": "R", "orcid": "0000-0002-5024-1713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e911a2d994434edbb736f77b7ccfcd72.json"}}, {"family": "Lamure", "given": "Sylvain", "initials": "S", "orcid": "0000-0001-5980-305X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0dc734a9a9e4016b2a1699809823fe2.json"}}, {"family": "Nucci", "given": "Marcio", "initials": "M", "orcid": "0000-0003-4867-0014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/abfb43328b9e49f5bb8a68af1dea23a9.json"}}, {"family": "Zambrotta", "given": "Giovanni", "initials": "G", "orcid": "0000-0002-8612-2994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa7e3e475561489d8a588f32256d8789.json"}}, {"family": "\u017d\u00e1k", "given": "Pavel", "initials": "P", "orcid": "0000-0003-4465-5343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/575505da6a594afd909f7d23ee161067.json"}}, {"family": "Seval", "given": "Guldane Cengiz", "initials": "GC", "orcid": "0000-0001-9433-2054", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e3b8c93389cf44fbabefe0d826d98f90.json"}}, {"family": "Bonuomo", "given": "Valentina", "initials": "V", "orcid": "0000-0001-6491-8337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/71cfcc19d793475898e9a4e94d9ba5ba.json"}}, {"family": "Mayer", "given": "Ji\u0159\u00ed", "initials": "J", "orcid": "0000-0003-0567-9887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af07e6256c3c4aa086315372fdbbc25c.json"}}, {"family": "L\u00f3pez-Garc\u00eda", "given": "Alberto", "initials": "A", "orcid": "0000-0002-5354-5261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c785356a67e4cbb9835fe9ce04a6153.json"}}, {"family": "Sacchi", "given": "Maria Vittoria", "initials": "MV", "orcid": "0000-0001-8133-3357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62e9765439304851b3d996f5a4ce6603.json"}}, {"family": "Booth", "given": "Stephen", "initials": "S", "orcid": "0000-0003-2687-0234", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d01b042ad524b7f8f5e6ac4486c2121.json"}}, {"family": "Ciceri", "given": "Fabio", "initials": "F", "orcid": "0000-0003-0873-0123", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/409a23f2dc8143a18aba6f8b91e597c7.json"}}, {"family": "Oberti", "given": "Margherita", "initials": "M"}, {"family": "Salvini", "given": "Marco", "initials": "M"}, {"family": "Izuzquiza", "given": "Macarena", "initials": "M"}, {"family": "Nunes-Rodrigues", "given": "Raquel", "initials": "R", "orcid": "0000-0002-8347-4281", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59fe3851cbd1404395c359435a99edbf.json"}}, {"family": "Ammatuna", "given": "Emanuele", "initials": "E", "orcid": "0000-0001-8247-4901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5904d1457399478aaaba50bcc584d502.json"}}, {"family": "Obr", "given": "Ale\u0161", "initials": "A", "orcid": "0000-0002-6758-3074", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35684b424cde4350a32f7ea16e0c9093.json"}}, {"family": "Herbrecht", "given": "Raoul", "initials": "R", "orcid": "0000-0002-9381-4876", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d015f48d57ac4543b0d5a5965582f46e.json"}}, {"family": "N\u00fa\u00f1ez-Mart\u00edn-Buitrago", "given": "Luc\u00eda", "initials": "L"}, {"family": "Mancini", "given": "Valentina", "initials": "V"}, {"family": "Shwaylia", "given": "Hawraa", "initials": "H", "orcid": "0000-0002-4098-6092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd1fea4026e941a98fa7c6f7a084bdb6.json"}}, {"family": "Scium\u00e8", "given": "Mariarita", "initials": "M", "orcid": "0000-0001-7958-4966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f9857d37d7041a3ae43ee186a3d0629.json"}}, {"family": "Essame", "given": "Jenna", "initials": "J", "orcid": "0000-0003-0926-5577", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e742441946aa4011877daa743e29be52.json"}}, {"family": "Nygaard", "given": "Marietta", "initials": "M"}, {"family": "Batini\u0107", "given": "Josip", "initials": "J", "orcid": "0000-0001-5595-9911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d11d10189d71468e9e606ab7b428327c.json"}}, {"family": "Gonzaga", "given": "Yung", "initials": "Y", "orcid": "0000-0003-1416-2118", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ff6be47e1ad4b729cdc6d4648073464.json"}}, {"family": "Regalado-Artamendi", "given": "Isabel", "initials": "I", "orcid": "0000-0002-9673-9015", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4527d7987ea449ff9a3d6e3135c54018.json"}}, {"family": "Karlsson", "given": "Linda Katharina", "initials": "LK", "orcid": "0000-0003-3317-7550", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7755dec3898c4e33a5729825a8d2dacd.json"}}, {"family": "Shapetska", "given": "Maryia", "initials": "M", "orcid": "0000-0002-1223-9161", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87e2b1bfa19d48d5892330aa3114c9ba.json"}}, {"family": "Hanakova", "given": "Michaela", "initials": "M"}, {"family": "El-Ashwah", "given": "Shaimaa", "initials": "S", "orcid": "0000-0003-2210-1534", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46dc0125ae354da09dddd0ffd083d199.json"}}, {"family": "Borb\u00e9nyi", "given": "Zita", "initials": "Z"}, {"family": "\u00c7olak", "given": "G\u00f6k\u00e7e Melis", "initials": "GM", "orcid": "0000-0002-7662-7454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42d2006ada9e473db89249bc882d6083.json"}}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Dragonetti", "given": "Giulia", "initials": "G", "orcid": "0000-0003-1775-6333", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81694822ac4d4074bfabe757d03f5f9e.json"}}, {"family": "Maraglino", "given": "Alessio Maria Edoardo", "initials": "AME"}, {"family": "Rinaldi", "given": "Amelia", "initials": "A", "orcid": "0000-0002-8211-5076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/689f30c83b4e4da7a48d853abd22d6e5.json"}}, {"family": "De Ram\u00f3n-S\u00e1nchez", "given": "Cristina", "initials": "C", "orcid": "0000-0002-8167-6410", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d42267ab742491d95080c6592197d6a.json"}}, {"family": "Cornely", "given": "Oliver A", "initials": "OA", "orcid": "0000-0001-9599-3137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3c62d8346924e69b6c99e4007c3831c.json"}}, {"family": "EPICOVIDEHA working group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-10-14", "journal": {"title": "J Hematol Oncol", "issn": "1756-8722", "volume": "14", "issue": "1", "pages": "168", "issn-l": null}, "abstract": "Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics of HM patients developing COVID-19 and analyzed predictors of mortality.\n\nThe survey was supported by the Scientific Working Group Infection in Hematology of the European Hematology Association (EHA). Eligible for the analysis were adult patients with HM and laboratory-confirmed COVID-19 observed between March and December 2020.\n\nThe study sample includes 3801 cases, represented by lymphoproliferative (mainly non-Hodgkin lymphoma n = 1084, myeloma n = 684 and chronic lymphoid leukemia n = 474) and myeloproliferative malignancies (mainly acute myeloid leukemia n = 497 and myelodysplastic syndromes n = 279). Severe/critical COVID-19 was observed in 63.8% of patients (n = 2425). Overall, 2778 (73.1%) of the patients were hospitalized, 689 (18.1%) of whom were admitted to intensive care units (ICUs). Overall, 1185 patients (31.2%) died. The primary cause of death was COVID-19 in 688 patients (58.1%), HM in 173 patients (14.6%), and a combination of both COVID-19 and progressing HM in 155 patients (13.1%). Highest mortality was observed in acute myeloid leukemia (199/497, 40%) and myelodysplastic syndromes (118/279, 42.3%). The mortality rate significantly decreased between the first COVID-19 wave (March-May 2020) and the second wave (October-December 2020) (581/1427, 40.7% vs. 439/1773, 24.8%, p value < 0.0001). In the multivariable analysis, age, active malignancy, chronic cardiac disease, liver disease, renal impairment, smoking history, and ICU stay correlated with mortality. Acute myeloid leukemia was a higher mortality risk than lymphoproliferative diseases.\n\nThis survey confirms that COVID-19 patients with HM are at high risk of lethal complications. However, improved COVID-19 prevention has reduced mortality despite an increase in the number of reported cases.", "doi": "10.1186/s13045-021-01177-0", "pmid": "34649563", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13045-021-01177-0"}], "notes": [], "created": "2021-10-21T05:05:31.090Z", "modified": "2021-10-21T05:05:33.687Z"}, {"entity": "publication", "iuid": "63244c74094741c59119d7f7977b6905", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63244c74094741c59119d7f7977b6905.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63244c74094741c59119d7f7977b6905"}}, "title": "A Spatial Analysis of COVID-19 in African Countries: Evaluating the Effects of Socio-Economic Vulnerabilities and Neighbouring.", "authors": [{"family": "Manda", "given": "Samuel O M", "initials": "SOM", "orcid": "0000-0002-9672-3312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b073c7d0b3d40e5acc15d6be304fd24.json"}}, {"family": "Darikwa", "given": "Timotheus", "initials": "T", "orcid": "0000-0002-6555-3154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e75f35ad6d94666a549b45c65f038ca.json"}}, {"family": "Nkwenika", "given": "Tshifhiwa", "initials": "T"}, {"family": "Bergquist", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2021-10-14", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "20", "issn-l": null}, "abstract": "The ongoing highly contagious coronavirus disease 2019 (COVID-19) pandemic, which started in Wuhan, China, in December 2019, has now become a global public health problem. Using publicly available data from the COVID-19 data repository of Our World in Data, we aimed to investigate the influences of spatial socio-economic vulnerabilities and neighbourliness on the COVID-19 burden in African countries. We analyzed the first wave (January-September 2020) and second wave (October 2020 to May 2021) of the COVID-19 pandemic using spatial statistics regression models. As of 31 May 2021, there was a total of 4,748,948 confirmed COVID-19 cases, with an average, median, and range per country of 101,041, 26,963, and 2191 to 1,665,617, respectively. We found that COVID-19 prevalence in an Africa country was highly dependent on those of neighbouring Africa countries as well as its economic wealth, transparency, and proportion of the population aged 65 or older (p-value < 0.05). Our finding regarding the high COVID-19 burden in countries with better transparency and higher economic wealth is surprising and counterintuitive. We believe this is a reflection on the differences in COVID-19 testing capacity, which is mostly higher in more developed countries, or data modification by less transparent governments. Country-wide integrated COVID suppression strategies such as limiting human mobility from more urbanized to less urbanized countries, as well as an understanding of a county's social-economic characteristics, could prepare a country to promptly and effectively respond to future outbreaks of highly contagious viral infections such as COVID-19.", "doi": "10.3390/ijerph182010783", "pmid": "34682528", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph182010783"}], "notes": [], "created": "2021-10-26T18:15:49.424Z", "modified": "2021-10-26T18:15:49.522Z"}, {"entity": "publication", "iuid": "872d89e3d1164efeb1fb997c306b26c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/872d89e3d1164efeb1fb997c306b26c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/872d89e3d1164efeb1fb997c306b26c0"}}, "title": "A Longitudinal Study of Gambling Behaviors During the COVID-19 Pandemic in Sweden.", "authors": [{"family": "M\u00e5nsson", "given": "Viktor", "initials": "V"}, {"family": "Wall", "given": "H\u00e5kan", "initials": "H"}, {"family": "Berman", "given": "Anne H", "initials": "AH"}, {"family": "Jayaram-Lindstr\u00f6m", "given": "Nitya", "initials": "N"}, {"family": "Rosendahl", "given": "Ingvar", "initials": "I"}], "type": "journal article", "published": "2021-10-14", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "708037", "issn-l": "1664-1078"}, "abstract": "This study aimed to investigate changes in gambling behaviors during the first and second waves of the COVID-19 pandemic in Sweden. Participants who had gambled within the past year were recruited from social media and the Swedish National Helpline (n = 325, mean age 39.8 years, 64.8% males, 31.3% with problem gambling) and completed an online survey measuring gambling behaviors, consequences of the pandemic in general and worries related to the pandemic. A sub-sample (n = 139) completed a follow-up survey, during the second wave. The results showed no significant associations between COVID-19 consequences (financial or increased isolation) and increased monthly gambling behavior. No major migrations were observed between game types. However, gambling on a high-risk game (OR = 7.44, p < 0.001) and worrying about mental health due to the pandemic (OR = 2.85, p < 0.001) were significantly associated with past year gambling problems and increased monthly gambling problems from the first to the second wave. More longitudinal research is needed in vulnerable populations, to fully understand the long-term consequences of the pandemic.", "doi": "10.3389/fpsyg.2021.708037", "pmid": "34721154", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8552012"}], "notes": [], "created": "2021-11-02T15:31:07.371Z", "modified": "2023-06-19T14:25:06.196Z"}, {"entity": "publication", "iuid": "59a5b39a1bad4ee2b05041ad5334f949", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/59a5b39a1bad4ee2b05041ad5334f949.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/59a5b39a1bad4ee2b05041ad5334f949"}}, "title": "The effects of a physical and cognitive training intervention vs. physical training alone on older adults' physical activity: A randomized controlled trial with extended follow-up during COVID-19.", "authors": [{"family": "Savikangas", "given": "Tiina", "initials": "T", "orcid": "0000-0002-8367-4304", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00e78fc921a64887bbb3accdba9da9fc.json"}}, {"family": "T\u00f6rm\u00e4kangas", "given": "Timo", "initials": "T"}, {"family": "Tirkkonen", "given": "Anna", "initials": "A"}, {"family": "Alen", "given": "Markku", "initials": "M"}, {"family": "Fielding", "given": "Roger A", "initials": "RA"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Rantalainen", "given": "Timo", "initials": "T"}, {"family": "Stigsdotter Neely", "given": "Anna", "initials": "A"}, {"family": "Sipil\u00e4", "given": "Sarianna", "initials": "S"}], "type": "journal article", "published": "2021-10-13", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0258559", "issn-l": "1932-6203"}, "abstract": "Executive functions underlie self-regulation and are thus important for physical activity and adaptation to new situations. The aim was to investigate, if yearlong physical and cognitive training (PTCT) had greater effects on physical activity among older adults than physical training (PT) alone, and if executive functions predicted physical activity at baseline, after six (6m) and twelve months (12m) of the interventions, one-year post-intervention follow-up and an extended follow-up during COVID-19 lockdown.\n\nData from a single-blinded, parallel-group randomized controlled trial (PASSWORD-study, ISRCTN52388040) were utilized. Participants were 70-85 years old community-dwelling men and women from Jyv\u00e4skyl\u00e4, Finland. PT (n = 159) included supervised resistance, walking and balance training, home-exercises and self-administered moderate activity. PTCT (n = 155) included PT and cognitive training targeting executive functions on a computer program. Physical activity was assessed with a one-item, seven-scale question. Executive functions were assessed with color-word Stroop, Trail Making Test (TMT) B-A and Letter Fluency. Changes in physical activity were modeled with multinomial logistic models and the impact of executive functions on physical activity with latent change score models.\n\nNo significant group-by-time interaction was observed for physical activity (p>0.1). The subjects were likely to select an activity category higher than baseline throughout the study (pooled data: B = 0.720-1.614, p<0.001-0.046). Higher baseline Stroop predicted higher physical activity through all subsequent time-points (pooled data: B = 0.011-0.013, p = 0.015-0.030). Higher baseline TMT B-A predicted higher physical activity at 6m (pooled data: B = 0.007, p = 0.006) and during COVID-19 (B = 0.005, p = 0.030). In the PT group, higher baseline Letter Fluency predicted higher physical activity at 12m (B = -0.028, p = 0.030) and follow-up (B = -0.042, p = 0.002).\n\nCognitive training did not have additive effects over physical training alone on physical activity, but multicomponent training and higher executive function at baseline may support adaptation to and maintenance of a physically active lifestyle among older adults.", "doi": "10.1371/journal.pone.0258559", "pmid": "34644357", "labels": {"Category: Proteins": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-19624"}, {"db": "pmc", "key": "PMC8513828"}], "notes": [], "created": "2021-10-21T05:07:40.043Z", "modified": "2021-10-21T05:07:40.098Z"}, {"entity": "publication", "iuid": "d70904b2b74441ef99cf0b79c91e8245", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d70904b2b74441ef99cf0b79c91e8245.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d70904b2b74441ef99cf0b79c91e8245"}}, "title": "SARS\u2013CoV\u20132 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro", "authors": [{"family": "Jiang", "given": "Hui", "initials": "H"}, {"family": "Mei", "given": "Ya Fang", "initials": "YF"}], "type": "journal-article", "published": "2021-10-13", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "10", "pages": "2056", "issn-l": "1999-4915"}, "abstract": null, "doi": "10.3390/v13102056", "pmid": null, "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:30:44.079Z", "modified": "2021-10-26T18:30:56.036Z"}, {"entity": "publication", "iuid": "1fd3d388b8404b7f82e9e5d7bffc160b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1fd3d388b8404b7f82e9e5d7bffc160b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1fd3d388b8404b7f82e9e5d7bffc160b"}}, "title": "Impact of obesity on intensive care outcomes in patients with COVID-19 in Sweden-A cohort study.", "authors": [{"family": "Sj\u00f6gren", "given": "Lovisa", "initials": "L", "orcid": "0000-0002-3425-0900", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e6cd7d544c04167bfb5cd8e7c7dc09f.json"}}, {"family": "Stenberg", "given": "Erik", "initials": "E", "orcid": "0000-0001-9189-0093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d991f094120449a7afaea3d92ade6db9.json"}}, {"family": "Thuccani", "given": "Meena", "initials": "M", "orcid": "0000-0003-2505-5596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/051393fe34b1472a83912bcf7b68713f.json"}}, {"family": "Martikainen", "given": "Jari", "initials": "J"}, {"family": "Rylander", "given": "Christian", "initials": "C", "orcid": "0000-0002-4534-7150", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/547f0c635e8144068a5dde0809547036.json"}}, {"family": "Wallenius", "given": "Ville", "initials": "V"}, {"family": "Olbers", "given": "Torsten", "initials": "T"}, {"family": "Kindblom", "given": "Jenny M", "initials": "JM", "orcid": "0000-0001-8437-0639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b24d2c900a84492a6e2974e5cf43751.json"}}], "type": "journal article", "published": "2021-10-13", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0257891", "issn-l": "1932-6203"}, "abstract": "Previous studies have shown that a high body mass index (BMI) is a risk factor for severe COVID-19. The aim of the present study was to assess whether a high BMI affects the risk of death or prolonged length of stay (LOS) in patients with COVID-19 during intensive care in Sweden.\n\nIn this observational, register-based study, we included patients with COVID-19 from the Swedish Intensive Care Registry admitted to intensive care units (ICUs) in Sweden. Outcomes assessed were death during intensive care and ICU LOS \u226514 days. We used logistic regression models to evaluate the association (odds ratio [OR] and 95% confidence interval [CI]) between BMI and the outcomes. Valid weight and height information could be retrieved in 1,649 patients (1,227 (74.4%) males) with COVID-19. We found a significant association between BMI and the risk of the composite outcome death or LOS \u226514 days in survivors (OR per standard deviation [SD] increase 1.30, 95%CI 1.16-1.44, adjusted for sex, age and comorbidities), and this association remained after further adjustment for severity of illness (simplified acute physiology score; SAPS3) at ICU admission (OR 1.30 per SD, 95%CI 1.17-1.45). Individuals with a BMI \u2265 35 kg/m2 had a doubled risk of the composite outcome. A high BMI was also associated with death during intensive care and a prolonged LOS in survivors assessed as separate outcomes. The main limitations were the restriction to the first wave of the pandemic, and the lack of information on socioeconomic status as well as smoking.\n\nIn this large cohort of Swedish ICU patients with COVID-19, a high BMI was associated with increasing risk of death and prolonged length of stay in the ICU. Based on our findings, we suggest that individuals with obesity should be more closely monitored when hospitalized for COVID-19.", "doi": "10.1371/journal.pone.0257891", "pmid": "34644316", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-22724"}, {"db": "pmc", "key": "PMC8513867"}], "notes": [], "created": "2021-10-21T05:08:00.061Z", "modified": "2021-10-21T05:08:00.267Z"}, {"entity": "publication", "iuid": "3a3e58bd90064b3889ef266c9471110b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a3e58bd90064b3889ef266c9471110b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a3e58bd90064b3889ef266c9471110b"}}, "title": "e-Learning and Web-Based Tools for Psychosocial Interventions Addressing Neuropsychiatric Symptoms of Dementia During the COVID-19 Pandemic in Tokyo, Japan: Quasi-Experimental Study.", "authors": [{"family": "Nakanishi", "given": "Miharu", "initials": "M", "orcid": "0000-0001-6200-9279", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/636f9920978f486c9148c073564a4b23.json"}}, {"family": "Yamasaki", "given": "Syudo", "initials": "S", "orcid": "0000-0002-9016-6404", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/703e839a200b4ef6b08be4c522562931.json"}}, {"family": "Endo", "given": "Kaori", "initials": "K", "orcid": "0000-0003-0854-5120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5173896a62eb481c8038090c4d1eb7a4.json"}}, {"family": "Niimura", "given": "Junko", "initials": "J", "orcid": "0000-0003-4404-055X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9765c54292f43ada4e4cb6448f9bed6.json"}}, {"family": "Ziylan", "given": "Canan", "initials": "C", "orcid": "0000-0002-7158-9508", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2af0a33c64c40a3ad69a89ac7c939fb.json"}}, {"family": "Bakker", "given": "Ton J E M", "initials": "TJEM", "orcid": "0000-0002-3773-5436", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6367f3e0f65340f5b699bcb1de688d1c.json"}}, {"family": "Granvik", "given": "Eva", "initials": "E", "orcid": "0000-0002-8862-8104", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b843c73baad49ac8c840c276621e567.json"}}, {"family": "N\u00e4gga", "given": "Katarina", "initials": "K", "orcid": "0000-0003-0194-8402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd0282d0489a4ee59dfe4f2fb4028093.json"}}, {"family": "Nishida", "given": "Atsushi", "initials": "A", "orcid": "0000-0001-6451-7699", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06cc5741754740a29041e4377f9207c3.json"}}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "JMIR Med Educ", "issn": "2369-3762", "volume": "7", "issue": "4", "pages": "e30652", "issn-l": null}, "abstract": "Concern has been raised that the COVID-19 pandemic and consequent social distancing measures may increase neuropsychiatric symptoms in people with dementia. Thus, we developed and delivered an e-learning training course to professional caregivers on using a web-based tool for psychosocial interventions for people with dementia.\n\nThe aim of our study was to evaluate the feasibility and efficacy of an e-learning course in combination with a web-based tool in addressing neuropsychiatric symptoms of dementia.\n\nA quasi-experimental design was used in Tokyo, Japan. The e-learning course was delivered three times to professional caregivers between July and December 2020. Caregivers who completed the course assessed the level of neuropsychiatric symptoms in people with dementia using the total score from the Neuropsychiatric Inventory (NPI) via a web-based tool. The primary outcome measures were the number of caregivers who implemented follow-up NPI evaluations by March 2021 and the change in NPI scores from baseline to their most recent follow-up evaluations. As a control group, information was also obtained from professional caregivers who completed a face-to-face training course using the same web-based tool between July 2019 and March 2020.\n\nA total of 268 caregivers completed the e-learning course in 2020. Of the 268 caregivers, 56 (20.9%) underwent follow-up evaluations with 63 persons with dementia. The average NPI score was significantly reduced from baseline (mean 20.4, SD 16.2) to the most recent follow-up evaluations (mean 14.3, SD 13.4). The effect size was assumed to be medium (Cohen drm [repeated measures]=0.40). The control group consisted of 252 caregivers who completed a face-to-face training course. Of the 252 caregivers, 114 (45.2%) underwent follow-up evaluations. Compared to the control group, caregivers who completed the e-learning course were significantly less likely to implement follow-up evaluations (\u03c721=52.0, P<.001). The change in NPI scores did not differ according to the type of training course (baseline-adjusted difference=-0.61, P=.69).\n\nThe replacement of face-to-face training with e-learning may have provided professionals with an opportunity to participate in the dementia behavior analysis and support enhancement (DEMBASE) program who may not have participated in the program otherwise. Although the program showed equal efficacy in terms of the two training courses, the feasibility was suboptimal with lower implementation levels for those receiving e-learning training. Thus, further strategies should be developed to improve feasibility by providing motivational triggers for implementation and technical support for care professionals. Using online communities in the program should also be investigated.", "doi": "10.2196/30652", "pmid": "34543224", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "v7i4e30652"}], "notes": [], "created": "2021-10-27T05:10:03.327Z", "modified": "2021-10-27T05:10:03.664Z"}, {"entity": "publication", "iuid": "80870541003147a987d11a033caf0d0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/80870541003147a987d11a033caf0d0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/80870541003147a987d11a033caf0d0e"}}, "title": "Susceptibility to COVID-19 after High Exposure to Perfluoroalkyl Substances from Contaminated Drinking Water: An Ecological Study from Ronneby, Sweden.", "authors": [{"family": "Nielsen", "given": "Christel", "initials": "C", "orcid": "0000-0003-3940-7847", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/383974c5a9e04eae926013a19be0fcdc.json"}}, {"family": "J\u00f6ud", "given": "Anna", "initials": "A", "orcid": "0000-0001-7192-4911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e038a5ce2f5a47bd89e7c221651a3d24.json"}}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "20", "pages": "10702", "issn-l": null}, "abstract": "There is concern that immunotoxic environmental contaminants, particularly perfluoroalkyl substances (PFAS), may play a role in the clinical course of COVID-19 and epidemiologic studies are needed to answer if high-exposed populations are especially vulnerable in light of the ongoing pandemic. The objective was, therefore, to determine if exposure to highly PFAS-contaminated drinking water was associated with an increased incidence of COVID-19 in Ronneby, Sweden, during the first year of the pandemic. We conducted an ecological study determining the sex- and age-standardized incidence ratio (SIR) in the adult population relative to a neighboring reference town with similar demographic characteristics but with only background levels of exposure. In Sweden, COVID-19 is subject to mandatory reporting, and we retrieved aggregated data on all verified cases until 3 March 2021 from the Public Health Agency of Sweden. The SIR in Ronneby was estimated at 1.19 (95% CI: 1.12; 1.27). The results suggest a potential link between high PFAS exposure and susceptibility to COVID-19 that warrants further research to clarify causality.", "doi": "10.3390/ijerph182010702", "pmid": "34682448", "labels": {"Category: Health": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8535293"}, {"db": "pii", "key": "ijerph182010702"}], "notes": [], "created": "2021-10-26T18:16:13.491Z", "modified": "2023-06-19T14:58:56.423Z"}, {"entity": "publication", "iuid": "67ed46cf180649afb240d1aa9ebef4e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/67ed46cf180649afb240d1aa9ebef4e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/67ed46cf180649afb240d1aa9ebef4e1"}}, "title": "Public justification and expert disagreement over non-pharmaceutical interventions for the COVID-19 pandemic.", "authors": [{"family": "Dahlquist", "given": "Marcus", "initials": "M"}, {"family": "Kugelberg", "given": "Henrik D", "initials": "HD", "orcid": "0000-0001-5119-646X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7330f66aa494bd1af8c79f6c9040620.json"}}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "J Med Ethics", "issn": "1473-4257", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "A wide range of non-pharmaceutical interventions (NPIs) have been introduced to stop or slow down the COVID-19 pandemic. Examples include school closures, environmental cleaning and disinfection, mask mandates, restrictions on freedom of assembly and lockdowns. These NPIs depend on coercion for their effectiveness, either directly or indirectly. A widely held view is that coercive policies need to be publicly justified-justified to each citizen-to be legitimate. Standardly, this is thought to entail that there is a scientific consensus on the factual propositions that are used to support the policies. In this paper, we argue that such a consensus has been lacking on the factual propositions justifying most NPIs. Consequently, they would on the standard view be illegitimate. This is regrettable since there are good reasons for granting the state the legitimate authority to enact NPIs under conditions of uncertainty. The upshot of our argument is that it is impossible to have both the standard interpretation of the permissibility of empirical claims in public justification and an effective pandemic response. We provide an alternative view that allows the state sufficient room for action while precluding the possibility of it acting without empirical support.", "doi": "10.1136/medethics-2021-107671", "pmid": "34642238", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "medethics-2021-107671"}], "notes": [], "created": "2021-10-21T05:08:50.893Z", "modified": "2022-02-17T11:29:15.608Z"}, {"entity": "publication", "iuid": "cbcfcaa21cfc4797bf135d15cff0e99a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cbcfcaa21cfc4797bf135d15cff0e99a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cbcfcaa21cfc4797bf135d15cff0e99a"}}, "title": "Prospective epidemiological, molecular, and genetic characterization of a novel coronavirus disease in the Val Venosta/Vinschgau: the CHRIS COVID-19 study protocol.", "authors": [{"family": "Pattaro", "given": "Cristian", "initials": "C", "orcid": "0000-0002-4119-0109", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf5065dd0f28451cbbe933b4a7de5985.json"}}, {"family": "Barbieri", "given": "Giulia", "initials": "G"}, {"family": "Foco", "given": "Luisa", "initials": "L", "orcid": "0000-0002-6694-3322", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/302e8d33f5154cfa9e61bae73c23eb36.json"}}, {"family": "Weichenberger", "given": "Christian X", "initials": "CX", "orcid": "0000-0002-2176-0274", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f73be54674f47cdb15cb55f83210783.json"}}, {"family": "Biasiotto", "given": "Roberta", "initials": "R"}, {"family": "De Grandi", "given": "Alessandro", "initials": "A"}, {"family": "Fuchsberger", "given": "Christian", "initials": "C"}, {"family": "Egger", "given": "Clemens", "initials": "C"}, {"family": "Amon", "given": "Vera S C", "initials": "VSC"}, {"family": "Hicks", "given": "Andrew A", "initials": "AA"}, {"family": "Mian", "given": "Michael", "initials": "M"}, {"family": "Mahlknecht", "given": "Angelika", "initials": "A"}, {"family": "Lombardo", "given": "Stefano", "initials": "S"}, {"family": "Meier", "given": "Horand", "initials": "H"}, {"family": "Weiss", "given": "Helmuth", "initials": "H"}, {"family": "Rainer", "given": "Robert", "initials": "R"}, {"family": "Dejaco", "given": "Christian", "initials": "C"}, {"family": "Weiss", "given": "G\u00fcnter", "initials": "G"}, {"family": "Lavezzo", "given": "Enrico", "initials": "E", "orcid": "0000-0002-3902-8356", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fdd6f6eb77a4a589afafc12955ca8d6.json"}}, {"family": "Crisanti", "given": "Andrea", "initials": "A"}, {"family": "Pizzato", "given": "Massimo", "initials": "M"}, {"family": "Domingues", "given": "Francisco S", "initials": "FS"}, {"family": "Mascalzoni", "given": "Deborah", "initials": "D"}, {"family": "G\u00f6gele", "given": "Martin", "initials": "M"}, {"family": "Melotti", "given": "Roberto", "initials": "R", "orcid": "0000-0003-4115-317X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9aadc5f020e74449a6ad0f6b87c55ec1.json"}}, {"family": "Pramstaller", "given": "Peter P", "initials": "PP"}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "Pathog Glob Health", "issn": "2047-7732", "pages": "1-9", "issn-l": null}, "abstract": "The COVID-19 pandemic has been threatening the healthcare and socioeconomic systems of entire nations. While population-based surveys to assess the distribution of SARS-CoV-2 infection have become a priority, pre-existing longitudinal studies are ideally suited to assess the determinants of COVID-19 onset and severity.The Cooperative Health Research In South Tyrol (CHRIS) study completed the baseline recruitment of 13,393 adults from the Venosta/Vinschgau rural district in 2018, collecting extensive phenotypic and biomarker data, metabolomic data, densely imputed genotype and whole-exome sequencing data.Based on CHRIS, we designed a prospective study, called CHRIS COVID-19, aimed at: 1) estimating the incidence of SARS-CoV-2 infections; 2) screening for and investigating the determinants of incident infection among CHRIS participants and their household members; 3) monitoring the immune response of infected participants prospectively.An online screening questionnaire was sent to all CHRIS participants and their household members. A random sample of 1450 participants representative of the district population was invited to assess active (nasopharyngeal swab) or past (serum antibody test) infections. We prospectively invited for complete SARS-CoV-2 testing all questionnaire completers gauged as possible cases of past infection and their household members. In positive tested individuals, antibody response is monitored quarterly for one year. Untested and negative participants receive the screening questionnaire every four weeks until gauged as possible incident cases or till the study end.Originated from a collaboration between researchers and community stakeholders, the CHRIS COVID-19 study aims at generating knowledge about the epidemiological, molecular, and genetic characterization of COVID-19 and its long-term sequelae.", "doi": "10.1080/20477724.2021.1978225", "pmid": "34637685", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8515786"}], "notes": [], "created": "2021-10-21T05:29:17.156Z", "modified": "2021-10-21T05:29:17.348Z"}, {"entity": "publication", "iuid": "ecfd334996f743f4b1001cd1f885ea98", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ecfd334996f743f4b1001cd1f885ea98.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ecfd334996f743f4b1001cd1f885ea98"}}, "title": "Organising labour market integration support for refugees in Austria and Sweden during the Covid-19 pandemic.", "authors": [{"family": "Be\u0161i\u0107", "given": "Almina", "initials": "A", "orcid": "0000-0003-4587-3609", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83a02c2a27944f7f8f3bf383b1dc1957.json"}}, {"family": "Diedrich", "given": "Andreas", "initials": "A"}, {"family": "Aigner", "given": "Petra", "initials": "P"}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "Comp Migr Stud", "issn": "2214-594X", "volume": "9", "issue": "1", "pages": "48", "issn-l": null}, "abstract": "This paper addresses the question of how the Covid-19 pandemic has affected the labour market integration support (LMIS) organised for refugees in Austria and Sweden, and the potential consequences of the changes unfolding. LMIS for refugees is a complex phenomenon involving actors at different interwoven levels-the macro-national level, the meso-organisational level and the micro-individual level. However, the complexities and consequences of such processes for the labour market integration of refugees have so far received limited attention. The current Covid-19 pandemic actualises the need to gain a better understanding of how integration support is organised across the different levels and how the pandemic itself impacts such support. Thus, the article seeks to understand how the pandemic affects the LMIS organised for refugees in Austria and Sweden, two countries with a large refugee population and diverging responses to the pandemic. Based on 29 semi-structured interviews and three focus group workshops, the results highlight in particular three developments: (a) a further entrenching of broader, macro-national level developments related to integration support already underway prior to the pandemic; (b) further mainstreaming of activities; and (c) increased volatility of work. Overall, the pandemic has brought to the fore the interrelation of different levels in the organising of LMIS for refugees and has contributed to a stabilisation of already ongoing activities.", "doi": "10.1186/s40878-021-00264-y", "pmid": "34660206", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "264"}, {"db": "pmc", "key": "PMC8507501"}], "notes": [], "created": "2021-10-21T05:01:14.127Z", "modified": "2021-10-21T05:01:14.195Z"}, {"entity": "publication", "iuid": "c54f0b8881fc4d8986c0453d0633d8d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c54f0b8881fc4d8986c0453d0633d8d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c54f0b8881fc4d8986c0453d0633d8d7"}}, "title": "High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells.", "authors": [{"family": "Sasamoto", "given": "Yuzuru", "initials": "Y"}, {"family": "Lee", "given": "Catherine A A", "initials": "CAA"}, {"family": "Yoshihara", "given": "Masahito", "initials": "M"}, {"family": "Martin", "given": "Gabrielle", "initials": "G"}, {"family": "Ksander", "given": "Bruce R", "initials": "BR"}, {"family": "Frank", "given": "Markus H", "initials": "MH"}, {"family": "Frank", "given": "Natasha Y", "initials": "NY"}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "Ocul Surf", "issn": "1937-5913", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jtos.2021.10.002", "pmid": "34653711", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1542-0124(21)00119-1"}], "notes": [], "created": "2021-10-21T05:04:34.147Z", "modified": "2021-10-21T05:04:34.184Z"}, {"entity": "publication", "iuid": "f78ed0896ec04ae2b27fe862816fab97", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f78ed0896ec04ae2b27fe862816fab97.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f78ed0896ec04ae2b27fe862816fab97"}}, "title": "Dynamic Interactions of Fully Glycosylated SARS-CoV-2 Spike Protein with Various Antibodies.", "authors": [{"family": "Cao", "given": "Yiwei", "initials": "Y", "orcid": "0000-0002-4516-8689", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15efd17a7c1342a3aa46bab1e2b9e241.json"}}, {"family": "Choi", "given": "Yeol Kyo", "initials": "YK", "orcid": "0000-0002-4218-7139", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2885ea927174b0aabe0ab76d5fba484.json"}}, {"family": "Frank", "given": "Martin", "initials": "M", "orcid": "0000-0002-1006-6746", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee6b5d165615455da3cf49fad65598e9.json"}}, {"family": "Woo", "given": "Hyeonuk", "initials": "H", "orcid": "0000-0002-6495-4087", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2dfd6c1c6f34de2b6b768ce70a67ebb.json"}}, {"family": "Park", "given": "Sang-Jun", "initials": "SJ", "orcid": "0000-0002-7307-3724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dede807702c34573bfe7de0b40c48de9.json"}}, {"family": "Yeom", "given": "Min Sun", "initials": "MS", "orcid": "0000-0001-9977-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7ae6fb73cfb47199fd5e4a468aa5554.json"}}, {"family": "Seok", "given": "Chaok", "initials": "C", "orcid": "0000-0002-1419-9888", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a93933221aa54cda9547eb7f063c154c.json"}}, {"family": "Im", "given": "Wonpil", "initials": "W", "orcid": "0000-0001-5642-6041", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c6b1fc87fa647459c5a112e9fa6b8ce.json"}}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "J Chem Theory Comput", "issn": "1549-9626", "issn-l": null, "volume": "17", "issue": "10", "pages": "6559-6569"}, "abstract": "The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents a public health crisis, and the vaccines that can induce highly potent neutralizing antibodies are essential for ending the pandemic. The spike (S) protein on the viral envelope mediates human angiotensin-converting enzyme 2 binding and thus is the target of a variety of neutralizing antibodies. In this work, we built various S trimer-antibody complex structures on the basis of the fully glycosylated S protein models described in our previous work and performed all-atom molecular dynamics simulations to gain insight into the structural dynamics and interactions between S protein and antibodies. Investigation of the residues critical for S-antibody binding allows us to predict the potential influence of mutations in SARS-CoV-2 variants. Comparison of the glycan conformations between S-only and S-antibody systems reveals the roles of glycans in S-antibody binding. In addition, we explored the antibody binding modes and the influences of antibody on the motion of S protein receptor binding domains. Overall, our analyses provide a better understanding of S-antibody interactions, and the simulation-based S-antibody interaction maps could be used to predict the influences of S mutation on S-antibody interactions, which will be useful for the development of vaccine and antibody-based therapy.", "doi": "10.1021/acs.jctc.1c00552", "pmid": "34529436", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null, "Category: Health": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC8457324"}], "notes": [], "created": "2021-09-20T16:50:33.864Z", "modified": "2023-06-19T14:35:10.854Z"}, {"entity": "publication", "iuid": "81d66a14c5ca493c826d3c9f0a089ec6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/81d66a14c5ca493c826d3c9f0a089ec6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/81d66a14c5ca493c826d3c9f0a089ec6"}}, "title": "Changes in Physical Activity Are Associated with Corresponding Changes in Psychological Well-Being: A Pandemic Case Study.", "authors": [{"family": "Dahlen", "given": "Micael", "initials": "M", "orcid": "0000-0001-6183-6520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5135c7c73d7f4eb89e26ec713dbfa2b8.json"}}, {"family": "Thorbj\u00f8rnsen", "given": "Helge", "initials": "H", "orcid": "0000-0002-2037-3336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46491c54156e4bdc85d376feda0fe55c.json"}}, {"family": "Sj\u00e5stad", "given": "Hallgeir", "initials": "H", "orcid": "0000-0002-8730-1038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9d4b3d4379f4e3bb43607c0ef08f159.json"}}, {"family": "von Heideken W\u00e5gert", "given": "Petra", "initials": "P", "orcid": "0000-0001-6292-7010", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4d6dfb26a37419385eb8e257f89d950.json"}}, {"family": "Hellstr\u00f6m", "given": "Charlotta", "initials": "C", "orcid": "0000-0003-1675-4408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a211ac4b50f24a3ca7be0deb42bc3362.json"}}, {"family": "Kerstis", "given": "Birgitta", "initials": "B", "orcid": "0000-0003-0242-0343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b50ad01a7fdd43b589b7ec07cf98f220.json"}}, {"family": "Lindberg", "given": "Daniel", "initials": "D", "orcid": "0000-0002-8541-1727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f40c1556e4545a3a69893d276425af9.json"}}, {"family": "Stier", "given": "Jonas", "initials": "J", "orcid": "0000-0001-7832-2155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7bd46d9d05214eef8e677e69a8878291.json"}}, {"family": "Elv\u00e9n", "given": "Maria", "initials": "M", "orcid": "0000-0001-5356-916X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d90589956db4920b99e166ed4c6dfb2.json"}}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "20", "pages": null}, "abstract": "Societal crises and personal challenges are often followed by substantial changes in physical activity. Is there a link between such changes and psychological well-being? Seeking to answer this question, we conducted a correlational study on a representative sample in Sweden during the first year of the COVID-19 pandemic (N = 1035). About 49% of the sample had decreased their physical activity compared to their self-reported activity level prior to the pandemic, whereas 32% had increased it. The results showed a positive and robust association between changes in daily activity level and corresponding changes in psychological well-being. Specifically, individuals who had reduced their physical activity over the last year reported lower life satisfaction than before, and individuals who had increased their physical activity reported higher life satisfaction than before. The amount of complete physical inactivity (sitting) showed a similar pattern as the exercise data, meaning that individuals who reported increasing inactivity per day also reported a greater decline in life satisfaction. Additional analyses showed that the association between daily activity level and life satisfaction was somewhat stronger for men than for women, but there was no difference when comparing individual versus organized activities. The current study was based on a cross-sectional design, measuring self-reported change over time. Recent work from other research teams have used longitudinal data and experience-sampling in different settings, finding similar results. We conclude that there is good reason to recommend physical exercise as a coping strategy in difficult times.", "doi": "10.3390/ijerph182010680", "pmid": "34682427", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "ijerph182010680"}], "notes": [], "created": "2021-10-26T18:14:07.931Z", "modified": "2022-02-17T10:50:21.789Z"}, {"entity": "publication", "iuid": "fcbefce66e1c493f8ecbc002ec69bd19", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fcbefce66e1c493f8ecbc002ec69bd19.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fcbefce66e1c493f8ecbc002ec69bd19"}}, "title": "What has the COVID-19 pandemic taught us about conducting patient and public involvement remotely? Insights from a series of digital meeting observations.", "authors": [{"family": "Lampa", "given": "Elin", "initials": "E", "orcid": "0000-0002-5467-5850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ca616474534489e933171c9819c3869.json"}}, {"family": "Sonnentheil", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "T\u00f6k\u00e9s", "given": "Ant\u00f3nia", "initials": "A"}, {"family": "Warner", "given": "Georgina", "initials": "G"}], "type": "letter", "published": "2021-10-11", "journal": {"title": "Res Involv Engagem", "issn": "2056-7529", "issn-l": null, "volume": "7", "issue": "1", "pages": "73"}, "abstract": "During the COVID-19 pandemic many work tasks are being done remotely through digital meetings, including PPI in research. Yet, some PPI activities have been paused or cancelled altogether during the pandemic. In this commentary, we share our insights from observing digital meetings with researchers and public contributors, representing vulnerable groups. Additionally, we discuss how remote PPI activities can be understood and improved.\r\n\r\nAs part of a PPI evaluation project, live observations were conducted by two trained observers, using a semi-structured observation protocol developed to objectively assess aspects of group dynamics in PPI research meetings with public contributors with experience of seeking refuge and parents facing economic hardship. This project's data collection is ongoing and the insights in this commentary is based on the observers' discussion. We discuss these insights through the lens of the Media Richness Theory, stating that the choice of media we communicate through should be guided by what kind of information we want to communicate to each other. The more complex the information is, the richer the media tool needs to be. For example, information in a text message is more easily misinterpreted than information given in person. This is because meeting in person gives us more information, for example through body language and tone of voice. Based on our experiences from observing digital research meetings, we give suggestions on how to improve digital meetings with public contributors. A few key points are: actively choosing which media to use; being prepared to guide contributors to the chosen media in a way that is suitable for them; and the increased importance of the person chairing the meeting to actively include all participants.\r\n\r\nWe reach the conclusion that digital meetings with public contributors is possible, but that researchers need to make a commitment and actively work to solve practical issues. Finally, the format and structure of digital meetings should be co-created together with public contributors.", "doi": "10.1186/s40900-021-00315-9", "pmid": "34635179", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s40900-021-00315-9"}, {"db": "pmc", "key": "PMC8503706"}], "notes": [], "created": "2021-10-21T05:40:42.818Z", "modified": "2022-02-17T10:29:45.446Z"}, {"entity": "publication", "iuid": "f20b9edbcf6644cf8ffc8e845358ae08", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f20b9edbcf6644cf8ffc8e845358ae08.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f20b9edbcf6644cf8ffc8e845358ae08"}}, "title": "Time-dependent evolution of IgG antibody levels after first and second dose of mRNA-based SARS-CoV-2 vaccination in hemodialysis patients: a multicenter study.", "authors": [{"family": "Santos-Ara\u00fajo", "given": "Carla", "initials": "C"}, {"family": "Veiga", "given": "Pedro Mota", "initials": "PM"}, {"family": "Santos", "given": "M\u00e1rio Jo\u00e3o", "initials": "MJ"}, {"family": "Santos", "given": "Lidia", "initials": "L"}, {"family": "Rom\u00e3ozinho", "given": "Catarina", "initials": "C"}, {"family": "Silva", "given": "M\u00f3nica", "initials": "M"}, {"family": "Lucas", "given": "Carlos", "initials": "C"}, {"family": "Duarte", "given": "Mary Luz", "initials": "ML"}, {"family": "Haarhaus", "given": "Mathias", "initials": "M"}, {"family": "Haase", "given": "Michael", "initials": "M"}, {"family": "Mac\u00e1rio", "given": "Fernando", "initials": "F"}], "type": "journal article", "published": "2021-10-11", "journal": {"title": "Nephrol Dial Transplant", "issn": "1460-2385", "issn-l": "0931-0509"}, "abstract": "Vaccination programs are essential for the containment of the COVID-19 pandemic, which has affected hemodialysis populations especially hard. Early reports suggest a reduced immunologic response to SARS-Cov-2 vaccines in dialysis patients, in spite of a high degree of seroconversion. We aimed to identify risk factors for a reduced efficacy of an mRNA vaccine in a cohort of hemodialysis patients.\n\nIn a multicenter study, including 294 Portuguese hemodialysis patients who had received 2 doses of BNT162b2 with a three week interval, IgG-class antibodies against the SARS-CoV-2 spike protein were determined 3 weeks after the first dose (M1) and 6 weeks after the second dose (M2). The threshold for seroconversion was 10UR/mL. Demographic and clinical data was retrieved from a quality registry. Adverse events were registered using a questionnaire.\n\nAt M2, seroconversion was 93.1% with a median antibody level of 197.5U/mL (1.2-3237.0) and a median increase of 180.0U/mL (-82.9-2244.6) from M1. Age (beta -8.9; 95%CI: -12.88 to -4.91; P < 0.0001), ferritin > 600ng/mL (beta 183.93; 95%CI: 74.75 to 293.10; P = 0.001) and physical activity (beta 265.79; 95%CI: 30.7 to 500.88; P = 0.03) were independent predictors of SARS-Cov-2 antibody levels after two vaccine doses. Plasma albumin > 3.5g/dL independently predicted the increase of antibody levels between both doses (OR 14.72; 95%CI: 1.38 to 157.45; P = 0.03). Only mild adverse reactions were observed in 10.9% of patients.\n\nThe SARS-Cov-2 vaccine BNT162b2 is safe and effective in hemodialysis patients. Besides age, iron status and nutrition are possible modifiable modulators of the immunologic response to SARS-Cov-2 mRNA vaccines. This data suggests the need for an early identification of populations at higher risk for diminished antibody production and the potential advantage of the implementation of oriented strategies to maximize the immune response to vaccination in these patients.", "doi": "10.1093/ndt/gfab293", "pmid": "34634116", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "6388402"}], "notes": [], "created": "2021-10-21T05:41:56.358Z", "modified": "2021-10-21T05:42:07.316Z"}, {"entity": "publication", "iuid": "278a382c799044f9b790db547410274d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/278a382c799044f9b790db547410274d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/278a382c799044f9b790db547410274d"}}, "title": "Longitudinal experiences and impact of the COVID-19 pandemic among people with past or current eating disorders in Sweden.", "authors": [{"family": "Birgeg\u00e5rd", "given": "Andreas", "initials": "A", "orcid": "0000-0003-1220-9680", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ffef11fa1954f97b80d3d3a6817e71a.json"}}, {"family": "Abbaspour", "given": "Afrouz", "initials": "A"}, {"family": "Borg", "given": "Stina", "initials": "S"}, {"family": "Clinton", "given": "David", "initials": "D"}, {"family": "Mantilla", "given": "Emma Fors\u00e9n", "initials": "EF"}, {"family": "Savva", "given": "Androula", "initials": "A"}, {"family": "Termorshuizen", "given": "Jet D", "initials": "JD"}, {"family": "Bulik", "given": "Cynthia M", "initials": "CM"}], "type": "journal article", "published": "2021-10-11", "journal": {"title": "Eat Disord", "issn": "1532-530X", "pages": "1-16", "issn-l": null}, "abstract": "The study aimed to document the impact of the COVID-19 pandemic on the health and well-being of individuals with past and current eating disorders (ED) in Sweden. We re-contacted participants with a known lifetime history of ED from two previous Swedish studies. Participants completed an online survey about health and functioning at baseline early in the pandemic (Wave 1 ca May/June 2020; N= 982) and six months later (Wave 2 Dec/Jan 2020/21; N= 646). Three important patterns emerged: 1) higher current ED symptoms were associated with greater anxiety, worry, and pandemic-related ED symptom increase; 2) patterns were fairly stable across time, although a concerning percentage (23%) who were symptom-free at Wave 1 reported the re-emergence of symptoms at Wave 2; and 3) only a minority of participants (<50%) with a current ED were in treatment, and of those in treatment, many reported fewer treatment sessions and decreased quality of care. The COVID-19 pandemic appears to pose serious health challenges for individuals with an ED, whether currently symptomatic or in remission. We encourage health service providers and patient advocates to be alert to the needs of individuals with ED and to take active measures to ensure access to appropriate evidence-based care both during and following the pandemic.", "doi": "10.1080/10640266.2021.1985286", "pmid": "34634228", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-21T05:41:17.737Z", "modified": "2021-10-21T05:41:17.812Z"}, {"entity": "publication", "iuid": "0bfed88b3c994d329226611fc1d5840d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0bfed88b3c994d329226611fc1d5840d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0bfed88b3c994d329226611fc1d5840d"}}, "title": "Increased risk of hospitalisation and intensive care admission associated with reported cases of SARS-CoV-2 variants B.1.1.7 and B.1.351 in Norway, December 2020 -May 2021.", "authors": [{"family": "Veneti", "given": "Lamprini", "initials": "L", "orcid": "0000-0002-9117-5310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/692998f77204424dba01972130b83448.json"}}, {"family": "Sepp\u00e4l\u00e4", "given": "Elina", "initials": "E"}, {"family": "Larsdatter Storm", "given": "Margrethe", "initials": "M"}, {"family": "Valcarcel Salamanca", "given": "Beatriz", "initials": "B"}, {"family": "Alnes Buanes", "given": "Eirik", "initials": "E"}, {"family": "Aasand", "given": "Nina", "initials": "N"}, {"family": "Naseer", "given": "Umaer", "initials": "U"}, {"family": "Bragstad", "given": "Karoline", "initials": "K"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "B\u00f8\u00e5s", "given": "H\u00e5kon", "initials": "H"}, {"family": "Kv\u00e5le", "given": "Reidar", "initials": "R"}, {"family": "Golestani", "given": "Karan", "initials": "K"}, {"family": "Feruglio", "given": "Siri", "initials": "S"}, {"family": "Vold", "given": "Line", "initials": "L"}, {"family": "Nyg\u00e5rd", "given": "Karin", "initials": "K"}, {"family": "Whittaker", "given": "Robert", "initials": "R", "orcid": "0000-0003-2810-7734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be98797b0c2a4de68e6e9599e4d1fb0e.json"}}], "type": "journal article", "published": "2021-10-11", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0258513", "issn-l": "1932-6203"}, "abstract": "Since their emergence, SARS-CoV-2 variants of concern (VOC) B.1.1.7 and B.1.351 have spread worldwide. We estimated the risk of hospitalisation and admission to an intensive care unit (ICU) for infections with B.1.1.7 and B.1.351 in Norway, compared to infections with non-VOC.\n\nUsing linked individual-level data from national registries, we conducted a cohort study on laboratory-confirmed cases of SARS-CoV-2 in Norway diagnosed between 28 December 2020 and 2 May 2021. Variants were identified based on whole genome sequencing, partial sequencing by Sanger sequencing or PCR screening for selected targets. The outcome was hospitalisation or ICU admission. We calculated adjusted risk ratios (aRR) with 95% confidence intervals (CIs) using multivariable binomial regression to examine the association between SARS-CoV-2 variants B.1.1.7 and B.1.351 with i) hospital admission and ii) ICU admission compared to non-VOC.\n\nWe included 23,169 cases of B.1.1.7, 548 B.1.351 and 4,584 non-VOC. Overall, 1,017 cases were hospitalised (3.6%) and 206 admitted to ICU (0.7%). B.1.1.7 was associated with a 1.9-fold increased risk of hospitalisation (aRR 95%CI 1.6-2.3) and a 1.8-fold increased risk of ICU admission (aRR 95%CI 1.2-2.8) compared to non-VOC. Among hospitalised cases, no difference was found in the risk of ICU admission between B.1.1.7 and non-VOC. B.1.351 was associated with a 2.4-fold increased risk of hospitalisation (aRR 95%CI 1.7-3.3) and a 2.7-fold increased risk of ICU admission (aRR 95%CI 1.2-6.5) compared to non-VOC.\n\nOur findings add to the growing evidence of a higher risk of severe disease among persons infected with B.1.1.7 or B.1.351. This highlights the importance of prevention and control measures to reduce transmission of these VOC in society, particularly ongoing vaccination programmes, and preparedness plans for hospital surge capacity.", "doi": "10.1371/journal.pone.0258513", "pmid": "34634066", "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-21292"}, {"db": "pmc", "key": "PMC8504717"}], "notes": [], "created": "2021-10-21T05:42:38.657Z", "modified": "2021-10-21T05:42:38.755Z"}, {"entity": "publication", "iuid": "ad0ade1d4f684a8e8ba203c034450fec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ad0ade1d4f684a8e8ba203c034450fec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ad0ade1d4f684a8e8ba203c034450fec"}}, "title": "Covid-19: Sweden, Norway, and Finland suspend use of Moderna vaccine in young people \"as a precaution\".", "authors": [{"family": "Paterlini", "given": "Marta", "initials": "M"}], "type": "journal article", "published": "2021-10-11", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "375", "pages": "n2477", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.n2477", "pmid": "34635488", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-10-21T05:31:27.906Z", "modified": "2021-10-21T05:31:27.921Z"}, {"entity": "publication", "iuid": "7e5e4f36da9748f9a7017365af6f787b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e5e4f36da9748f9a7017365af6f787b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e5e4f36da9748f9a7017365af6f787b"}}, "title": "Association Between Risk of COVID-19 Infection in Nonimmune Individuals and COVID-19 Immunity in Their Family Members.", "authors": [{"family": "Nordstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Ballin", "given": "Marcel", "initials": "M"}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-10-11", "journal": {"title": "JAMA Intern Med", "issn": "2168-6114", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The association between COVID-19 immunity within families and the risk of infection in nonimmune family members is unknown.\r\n\r\nTo investigate the association between risk of COVID-19 in nonimmune individuals and the number of their family members with known immunity acquired from a previous COVID-19 infection or full vaccination (2 vaccine doses).\r\n\r\nIn this cohort study of data from nationwide registries in Sweden, all individuals who acquired immunity from either previous COVID-19 infection or full vaccination until May 26, 2021, were considered for inclusion. Each person with immunity was matched 1:1 to an individual without immunity from an identified cohort of individuals with families comprising 2 to 5 members.\r\n\r\nNumber of immune family members in each family on April 14, 2021 (index date), who acquired immunity from a previous COVID-19 infection or full vaccination (2 doses of the mRNA-1273, BNT162b2 mRNA, or ChAdOx1 nCoV-19 vaccine).\r\n\r\nIncident COVID-19 infection in nonimmune family members from April 15 to May 26, 2021.\r\n\r\nA total of 1 789 728 individuals from 814 806 families were included in the analysis. Each family comprised 2 to 5 family members, with a mean (SD) age at baseline of 51.3 (19.5) years. During a mean (range) follow-up time of 26.3 (1-40) days, 88 797 of 1 549 989 (5.7%) nonimmune family members (mean [SD] age, 51.6 [17.7] years; 790 276 men [51.0%]) were diagnosed with COVID-19. There was an inverse dose-response association between the number of immune members in each family and the risk of incident COVID-19 infection in nonimmune family members. Nonimmune families with 1 immune family member had a 45% to 61% lower risk of contracting COVID-19 (hazard ratio [HR], 0.39-0.55; 95% CI, 0.37-0.61, P < .001). The risk reduction increased to 75% to 86% in families with 2 immune family members (HR, 0.14-0.25; 95% CI, 0.11-0.27; P < .001), 91% to 94% with 3 immune family members (HR, 0.06-0.09; 95% CI, 0.04-0.10; P < .001), and 97% with 4 immune family members (HR, 0.03; 95% CI, 0.02-0.05; P < .001). The results were similar for the outcome of COVID-19 infection that was severe enough to warrant a hospital stay.\r\n\r\nIn this cohort study, family members without immunity had a 45% to 97% lower risk of contracting COVID-19 as the number of immune family members increased. Vaccination is a key strategy for decreasing the transmission of the virus within families.", "doi": "10.1001/jamainternmed.2021.5814", "pmid": "34633407", "labels": {"Type: Journal article": null, "Category: Proteins": null}, "xrefs": [{"db": "pii", "key": "2785141"}], "notes": [], "created": "2021-10-21T05:44:00.849Z", "modified": "2021-10-21T05:45:09.824Z"}, {"entity": "publication", "iuid": "203b5fbee3e144d39ec6f59bfc384379", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/203b5fbee3e144d39ec6f59bfc384379.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/203b5fbee3e144d39ec6f59bfc384379"}}, "title": "Conquering the cytokine storm in COVID\u201019\u2010induced ARDS using placenta\u2010derived decidua stromal cells", "authors": [{"family": "Sadeghi", "given": "Behnam", "initials": "B", "orcid": "0000-0002-8721-0400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eadac43380f04ff58c964c3510e92151.json"}}, {"family": "Roshandel", "given": "Elham", "initials": "E"}, {"family": "Pirsalehi", "given": "Ali", "initials": "A"}, {"family": "Kazemi", "given": "Sepide", "initials": "S"}, {"family": "Sankanian", "given": "Ghazaleh", "initials": "G"}, {"family": "Majidi", "given": "Mohammad", "initials": "M"}, {"family": "Salimi", "given": "Maryam", "initials": "M"}, {"family": "Aghdami", "given": "Nasser", "initials": "N"}, {"family": "Sadrosadat", "given": "Hoda", "initials": "H"}, {"family": "Samadi Kochaksaraei", "given": "Sarvenaz", "initials": "S"}, {"family": "Alaeddini", "given": "Farshid", "initials": "F"}, {"family": "Ringden", "given": "Olle", "initials": "O"}, {"family": "Hajifathali", "given": "Abbas", "initials": "A"}], "type": "journal-article", "published": "2021-10-10", "journal": {"title": "J Cell Mol Med", "issn": "1582-1838", "issn-l": null}, "abstract": null, "doi": "10.1111/jcmm.16986", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:47:38.250Z", "modified": "2021-10-11T17:47:38.334Z"}, {"entity": "publication", "iuid": "64dc4d035e764b2593cd8aa0b4b542a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/64dc4d035e764b2593cd8aa0b4b542a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/64dc4d035e764b2593cd8aa0b4b542a4"}}, "title": "Transition to telehealth : Engaging medical students in telemedicine healthcare delivery.", "authors": [{"family": "Cheng", "given": "Chelsea", "initials": "C"}, {"family": "Humphreys", "given": "Hilary", "initials": "H", "orcid": "0000-0002-9646-2183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/743d1ac7fae6414881cdbbfd68ee700d.json"}}, {"family": "Kane", "given": "Bridget", "initials": "B", "orcid": "0000-0003-3211-6529", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4805745c1bc64db79cb7de66a19c24b9.json"}}], "type": "journal article", "published": "2021-10-09", "journal": {"title": "Ir J Med Sci", "issn": "1863-4362", "issn-l": null}, "abstract": "In recent years, telemedicine has been increasingly incorporated into medical practice, a process which has now been accelerated by the COVID-19 pandemic. As telemedicine continues to progress, it is necessary for medical institutions to incorporate telemedicine into their curricula, and to provide students with the necessary skills and experience to effectively carry out telemedicine consultations. The purposes of this study are to review the involvement of medical students with telemedicine and to determine both the benefits and the challenges experienced. A literature review on the MEDLINE; CINAHL Plus; APA PsychInfo; Library, Information Science and Technology Abstracts; and Health Business Elite databases was performed on September 7, 2020, yielding 561 results. 33 manuscripts were analysed, with the main benefits and challenges experienced by medical students summarized. In addition to increasing their understanding of the importance of telemedicine and the acquisition of telemedicine-specific skills, students may use telemedicine to act as a valuable workforce during the COVID-19 pandemic. Challenges that students face, such as discomfort with carrying out telemedicine consults and building rapport with patients, may be addressed through the incorporation of telemedicine teaching into the medical curricula through experiential learning. However, other more systemic challenges, such as technical difficulties and cost, need to be examined for the full benefits of telemedicine to be realized. Telemedicine is here to stay and has proven its worth during the COVID-19 pandemic, with medical students embracing its potential in assisting in medical clinics, simulation of clinical placements, and online classrooms.", "doi": "10.1007/s11845-021-02720-1", "pmid": "34626350", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11845-021-02720-1"}], "notes": [], "created": "2021-10-10T15:03:29.736Z", "modified": "2021-10-10T15:03:29.813Z"}, {"entity": "publication", "iuid": "9cf39ddf9f0c40979dc182c2bdcea414", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9cf39ddf9f0c40979dc182c2bdcea414.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9cf39ddf9f0c40979dc182c2bdcea414"}}, "title": "Severe COVID-19 among patients with asthma and COPD: a report from the Swedish National Airway Register.", "authors": [{"family": "Karlsson Sundbaum", "given": "Johanna", "initials": "J", "orcid": "0000-0001-5313-7981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8b5dfbfb761446aa474013fcccdd085.json"}}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW"}, {"family": "Konradsen", "given": "Jon R", "initials": "JR"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ekberg-Jansson", "given": "Ann", "initials": "A"}, {"family": "Stridsman", "given": "Caroline", "initials": "C", "orcid": "0000-0001-6622-3838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e2fc66fb68748eba5a7f8eb93c5ff3f.json"}}], "type": "journal article", "published": "2021-10-09", "journal": {"title": "Ther Adv Respir Dis", "issn": "1753-4666", "volume": "15", "pages": "17534666211049738", "issn-l": null}, "abstract": "Patients with obstructive lung diseases may be at risk of hospitalization and/or death due to COVID-19.\n\nTo estimate the frequency of severe COVID-19, and COVID-19-related mortality in a well-defined large population of patients with asthma and chronic inflammatory lung disease (COPD). Further to assess the frequency of asthma and COPD as registered comorbidities at discharge from hospital, and in death certificates.\n\nAt the start of the pandemic, the Swedish National Airway Register (SNAR) included 271,404 patients with a physician diagnosis of asthma and/or COPD. In September 2020, after the first COVID-19 wave in Sweden, the database was linked with the National Patient Register (NPR), the Swedish Intensive Care Register and the Swedish Cause of Death Register, which all provide data about COVID-19 based on International Classification of Diseases (ICD-10) codes. Severe COVID-19 was defined as hospitalization and/or intensive care or death due to COVID-19.\n\nAmong patients in SNAR, 0.5% with asthma, and 1.2% with COPD were identified with severe COVID-19. Among patients < 18 years with asthma, only 0.02% were severely infected. Of hospitalized adults, 14% with asthma and 29% with COPD died. Further, of patients in SNAR, 56% with asthma and 81% with COPD were also registered in the NPR, while on death certificates the agreement was lower (asthma 24% and COPD 71%).\n\nThe frequency of severe COVID-19 in asthma and COPD was relative low. Mortality for those hospitalized was double as high in COPD compared to asthma. Comorbid asthma and COPD were not always identified among patients with severe COVID-19.", "doi": "10.1177/17534666211049738", "pmid": "34623194", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:05:40.326Z", "modified": "2021-10-10T15:05:40.385Z"}, {"entity": "publication", "iuid": "79bc8a5e27924a4b85c44881e983c8fb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79bc8a5e27924a4b85c44881e983c8fb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79bc8a5e27924a4b85c44881e983c8fb"}}, "title": "Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: a systematic review and meta-analysis.", "authors": [{"family": "Vlieg-Boerstra", "given": "Berber", "initials": "B"}, {"family": "de Jong", "given": "Nicolette", "initials": "N"}, {"family": "Meyer", "given": "Rosan", "initials": "R"}, {"family": "Agostoni", "given": "Carlo", "initials": "C"}, {"family": "De Cosmi", "given": "Valentina", "initials": "V"}, {"family": "Grimshaw", "given": "Kate", "initials": "K"}, {"family": "Milani", "given": "Gregorio Paolo", "initials": "GP", "orcid": "0000-0003-3829-4254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ca1648b8a3104d04a1c1e76f1ab8515a.json"}}, {"family": "Muraro", "given": "Antonella", "initials": "A"}, {"family": "Oude Elberink", "given": "Hanneke", "initials": "H"}, {"family": "Pali-Sch\u00f6ll", "given": "Isabella", "initials": "I"}, {"family": "Roduit", "given": "Caroline", "initials": "C", "orcid": "0000-0002-5988-0570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e16166b1fbb40b7889c82489fbdb715.json"}}, {"family": "Sasaki", "given": "Mari", "initials": "M"}, {"family": "Skypala", "given": "Isabel", "initials": "I", "orcid": "0000-0003-3629-4293", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4c207bd30ab42c1867b02a860c67f77.json"}}, {"family": "Solokowska", "given": "Milena", "initials": "M"}, {"family": "van Splunter", "given": "Marloes", "initials": "M"}, {"family": "Untersmayr", "given": "Eva", "initials": "E", "orcid": "0000-0002-1963-499X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8992d441a29644549f96af3a610c41ed.json"}}, {"family": "Venter", "given": "Carina", "initials": "C", "orcid": "0000-0002-7473-5355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ad020ad75c949809aea99fc0b4a3e9b.json"}}, {"family": "O'Mahony", "given": "Liam", "initials": "L"}, {"family": "Nwaru", "given": "Bright I", "initials": "BI", "orcid": "0000-0002-2876-6089", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2cf3592613946dda1712a7e78dd4c73.json"}}], "type": "journal article", "published": "2021-10-09", "journal": {"title": "Allergy", "issn": "1398-9995", "issn-l": "0105-4538"}, "abstract": "It remains uncertain as to whether nutrient supplementation for the general population considered healthy could be useful in the prevention of RTIs, such as COVID-19. In this systematic review and meta-analysis the evidence was evaluated for primary prevention of any viral respiratory tract infection (RTI) such as SARS-CoV-2, through supplementation of nutrients with a recognized role in immune function: multiple micronutrients, vitamin A, folic acid, vitamin B12, C, D, E, beta-carotene, zinc, iron and long chain polyunsaturated fatty acids. The search produced 15,163 records of which 93 papers (based on 115 studies) met the inclusion criteria, resulting in 199,055 subjects (191,636 children and 7,419 adults) from 37 countries. Sixty-three studies were included in the meta-analyses, which was performed for children and adults separately. By stratifying the meta-analysis by world regions, only studies performed in Asia showed a significant, but heterogeneous protective effect of zinc supplementation on RTIs (RR 0.86, 95%CI 0.7-0.96, I2=79.1%, p=0.000). Vitamin D supplementation in adults significantly decreased the incidence of RTI (RR 0.89, 95%CI 0.79-0.99, p=0.272), particularly in North America (RR 0.82 95%CI 0.68-0.97), but not in Europe or Oceania. Supplementation of nutrients in the general population has either no, or at most a very limited effect on prevention of RTIs. Zinc supplementation appears protective for children in Asia, while vitamin D may protect adults in the USA and Canada. In 10/115 (8.7%) studies post-hoc analyses based on stratification for nutritional status was performed. In only one study zinc supplementation was found to be more effective in children with low zinc serum as compared to children with normal zinc serum levels.", "doi": "10.1111/all.15136", "pmid": "34626488", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:03:11.116Z", "modified": "2021-10-10T15:03:11.258Z"}, {"entity": "publication", "iuid": "017cd45892f94e0fa1011237ba243d3c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/017cd45892f94e0fa1011237ba243d3c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/017cd45892f94e0fa1011237ba243d3c"}}, "title": "Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.", "authors": [{"family": "Pablos", "given": "Isabel", "initials": "I"}, {"family": "Machado", "given": "Yoan", "initials": "Y"}, {"family": "de Jesus", "given": "Hugo C Ramos", "initials": "HCR"}, {"family": "Mohamud", "given": "Yasir", "initials": "Y"}, {"family": "Kappelhoff", "given": "Reinhild", "initials": "R"}, {"family": "Lindskog", "given": "Cecilia", "initials": "C"}, {"family": "Vlok", "given": "Marli", "initials": "M"}, {"family": "Bell", "given": "Peter A", "initials": "PA"}, {"family": "Butler", "given": "Georgina S", "initials": "GS"}, {"family": "Grin", "given": "Peter M", "initials": "PM"}, {"family": "Cao", "given": "Quynh T", "initials": "QT"}, {"family": "Nguyen", "given": "Jenny P", "initials": "JP"}, {"family": "Solis", "given": "Nestor", "initials": "N"}, {"family": "Abbina", "given": "Srinivas", "initials": "S"}, {"family": "Rut", "given": "Wioletta", "initials": "W"}, {"family": "Vederas", "given": "John C", "initials": "JC"}, {"family": "Szekely", "given": "Laszlo", "initials": "L"}, {"family": "Szakos", "given": "Attila", "initials": "A"}, {"family": "Drag", "given": "Marcin", "initials": "M"}, {"family": "Kizhakkedathu", "given": "Jayachandran N", "initials": "JN"}, {"family": "Mossman", "given": "Karen", "initials": "K"}, {"family": "Hirota", "given": "Jeremy A", "initials": "JA"}, {"family": "Jan", "given": "Eric", "initials": "E"}, {"family": "Luo", "given": "Honglin", "initials": "H"}, {"family": "Banerjee", "given": "Arinjay", "initials": "A"}, {"family": "Overall", "given": "Christopher M", "initials": "CM"}], "type": "journal article", "published": "2021-10-09", "journal": {"title": "Cell Rep", "issn": "2211-1247", "pages": "109892", "issn-l": null}, "abstract": "The main viral protease (3CLpro) is indispensable for SARS-CoV-2 replication. We delineate the human protein substrate landscape of 3CLpro by TAILS substrate-targeted N-terminomics. We identify more than 100 substrates in human lung and kidney cells supported by analyses of SARS-CoV-2-infected cells. Enzyme kinetics and molecular docking simulations of 3CLpro engaging substrates reveal how noncanonical cleavage sites, which diverge from SARS-CoV, guide substrate specificity. Cleaving the interactors of essential effector proteins, effectively stranding them from their binding partners, amplifies the consequences of proteolysis. We show that 3CLpro targets the Hippo pathway, including inactivation of MAP4K5, and key effectors of transcription, mRNA processing, and translation. We demonstrate that Spike glycoprotein directly binds galectin-8, with galectin-8 cleavage disengaging CALCOCO2/NDP52 to decouple antiviral-autophagy. Indeed, in post-mortem COVID-19 lung samples, NDP52 rarely colocalizes with galectin-8, unlike in healthy lungs. The 3CLpro substrate degradome establishes a foundational substrate atlas to accelerate exploration of SARS-CoV-2 pathology and drug design.", "doi": "10.1016/j.celrep.2021.109892", "pmid": "34672947", "labels": {"Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2211-1247(21)01362-0"}], "notes": [], "created": "2021-10-26T18:09:25.642Z", "modified": "2021-10-26T18:09:25.660Z"}, {"entity": "publication", "iuid": "8d509d3e380942b3b6dbddd4253d9966", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d509d3e380942b3b6dbddd4253d9966.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d509d3e380942b3b6dbddd4253d9966"}}, "title": "COVID-19 in patients with autoimmune diseases: characteristics and outcomes in a multinational network of cohorts across three countries.", "authors": [{"family": "Tan", "given": "Eng Hooi", "initials": "EH"}, {"family": "Sena", "given": "Anthony G", "initials": "AG", "orcid": "0000-0001-8630-5347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9202e069d9c24646b006b6abb640b541.json"}}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A", "orcid": "0000-0003-1202-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47f086bb6ccd49a2a5f11a32c06277c8.json"}}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Ahmed", "given": "Waheed-Ul-Rahman", "initials": "WU"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Duvall", "given": "Scott L", "initials": "SL"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "Bertolin", "given": "Sergio Fernandez", "initials": "SF"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Natarajan", "given": "Karthik", "initials": "K"}, {"family": "Falconer", "given": "Thomas", "initials": "T"}, {"family": "Spotnitz", "given": "Matthew", "initials": "M"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Blacketer", "given": "Clair", "initials": "C"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Lane", "given": "Jennifer C E", "initials": "JCE"}, {"family": "Dawoud", "given": "Dalia M", "initials": "DM"}, {"family": "Shah", "given": "Karishma", "initials": "K"}, {"family": "Yang", "given": "Yue", "initials": "Y"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Recalde", "given": "Martina", "initials": "M"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "Jonnagaddala", "given": "Jitendra", "initials": "J", "orcid": "0000-0002-9912-2344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8403290b9ec43fe93b558de97d84559.json"}}, {"family": "Subbian", "given": "Vignesh", "initials": "V"}, {"family": "Vizcaya", "given": "David", "initials": "D"}, {"family": "Lai", "given": "Lana Y H", "initials": "LYH"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Shah", "given": "Nigam H", "initials": "NH"}, {"family": "Gong", "given": "Mengchun", "initials": "M"}, {"family": "Vivekanantham", "given": "Arani", "initials": "A"}, {"family": "Abend", "given": "Aaron", "initials": "A"}, {"family": "Minty", "given": "Evan P", "initials": "EP"}, {"family": "Suchard", "given": "Marc", "initials": "M"}, {"family": "Rijnbeek", "given": "Peter", "initials": "P"}, {"family": "Ryan", "given": "Patrick B", "initials": "PB"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}], "type": "journal article", "published": "2021-10-09", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "volume": "60", "issue": "SI", "pages": "SI37-SI50", "issn-l": null}, "abstract": "Patients with autoimmune diseases were advised to shield to avoid coronavirus disease 2019 (COVID-19), but information on their prognosis is lacking. We characterized 30-day outcomes and mortality after hospitalization with COVID-19 among patients with prevalent autoimmune diseases, and compared outcomes after hospital admissions among similar patients with seasonal influenza.\n\nA multinational network cohort study was conducted using electronic health records data from Columbia University Irving Medical Center [USA, Optum (USA), Department of Veterans Affairs (USA), Information System for Research in Primary Care-Hospitalization Linked Data (Spain) and claims data from IQVIA Open Claims (USA) and Health Insurance and Review Assessment (South Korea). All patients with prevalent autoimmune diseases, diagnosed and/or hospitalized between January and June 2020 with COVID-19, and similar patients hospitalized with influenza in 2017-18 were included. Outcomes were death and complications within 30 days of hospitalization.\n\nWe studied 133 589 patients diagnosed and 48 418 hospitalized with COVID-19 with prevalent autoimmune diseases. Most patients were female, aged \u226550 years with previous comorbidities. The prevalence of hypertension (45.5-93.2%), chronic kidney disease (14.0-52.7%) and heart disease (29.0-83.8%) was higher in hospitalized vs diagnosed patients with COVID-19. Compared with 70 660 hospitalized with influenza, those admitted with COVID-19 had more respiratory complications including pneumonia and acute respiratory distress syndrome, and higher 30-day mortality (2.2-4.3% vs 6.32-24.6%).\n\nCompared with influenza, COVID-19 is a more severe disease, leading to more complications and higher mortality.", "doi": "10.1093/rheumatology/keab250", "pmid": "33725121", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6174122"}, {"db": "pmc", "key": "PMC7989171"}], "notes": [], "created": "2021-03-17T07:42:16.376Z", "modified": "2021-11-18T13:19:42.279Z"}, {"entity": "publication", "iuid": "a45f65dfd0c5498abfbfcc9164c2cb6c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a45f65dfd0c5498abfbfcc9164c2cb6c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a45f65dfd0c5498abfbfcc9164c2cb6c"}}, "title": "Rapid evaluation of Coronavirus Illness Severity (RECOILS) in intensive care: Development and validation of a prognostic tool for in-hospital mortality.", "authors": [{"family": "Ple\u010dko", "given": "Drago", "initials": "D", "orcid": "0000-0002-5433-196X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9f5f12451ca40b0a93e4f2491dd3a92.json"}}, {"family": "Bennett", "given": "Nicolas", "initials": "N"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J", "orcid": "0000-0001-8739-7896", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c2fb174ab842c8809900877de8c008.json"}}, {"family": "Dam", "given": "Tariq A", "initials": "TA"}, {"family": "Entjes", "given": "Robert", "initials": "R"}, {"family": "Rettig", "given": "Thijs C D", "initials": "TCD"}, {"family": "Dongelmans", "given": "Dave A", "initials": "DA"}, {"family": "Boelens", "given": "Age D", "initials": "AD"}, {"family": "Rigter", "given": "Sander", "initials": "S"}, {"family": "Hendriks", "given": "Stefaan H A", "initials": "SHA"}, {"family": "de Jong", "given": "Remko", "initials": "R"}, {"family": "Kamps", "given": "Marlijn J A", "initials": "MJA"}, {"family": "Peters", "given": "Marco", "initials": "M"}, {"family": "Karakus", "given": "Attila", "initials": "A"}, {"family": "Gommers", "given": "Diederik", "initials": "D"}, {"family": "Ramnarain", "given": "Dharmanand", "initials": "D"}, {"family": "Wils", "given": "Evert-Jan", "initials": "EJ"}, {"family": "Achterberg", "given": "Sefanja", "initials": "S"}, {"family": "Nowitzky", "given": "Ralph", "initials": "R"}, {"family": "van den Tempel", "given": "Walter", "initials": "W"}, {"family": "de Jager", "given": "Cornelis P C", "initials": "CPC"}, {"family": "Nooteboom", "given": "Fleur G C A", "initials": "FGCA"}, {"family": "Oostdijk", "given": "Evelien", "initials": "E"}, {"family": "Koetsier", "given": "Peter", "initials": "P"}, {"family": "Cornet", "given": "Alexander D", "initials": "AD"}, {"family": "Reidinga", "given": "Auke C", "initials": "AC"}, {"family": "de Ruijter", "given": "Wouter", "initials": "W"}, {"family": "Bosman", "given": "Rob J", "initials": "RJ"}, {"family": "Frenzel", "given": "Tim", "initials": "T"}, {"family": "Urlings-Strop", "given": "Louise C", "initials": "LC"}, {"family": "de Jong", "given": "Paul", "initials": "P"}, {"family": "Smit", "given": "Ellen G M", "initials": "EGM"}, {"family": "Cremer", "given": "Olaf L", "initials": "OL"}, {"family": "Mehagnoul-Schipper", "given": "D Jannet", "initials": "DJ"}, {"family": "Faber", "given": "Harald J", "initials": "HJ"}, {"family": "Lens", "given": "Judith", "initials": "J"}, {"family": "Brunnekreef", "given": "Gert B", "initials": "GB"}, {"family": "Festen-Spanjer", "given": "Barbara", "initials": "B"}, {"family": "Dormans", "given": "Tom", "initials": "T"}, {"family": "de Bruin", "given": "Daan P", "initials": "DP"}, {"family": "Lalisang", "given": "Robbert C A", "initials": "RCA"}, {"family": "Vonk", "given": "Sebastiaan J J", "initials": "SJJ"}, {"family": "Haan", "given": "Martin E", "initials": "ME"}, {"family": "Fleuren", "given": "Lucas M", "initials": "LM"}, {"family": "Thoral", "given": "Patrick J", "initials": "PJ"}, {"family": "Elbers", "given": "Paul W G", "initials": "PWG"}, {"family": "Bellomo", "given": "Rinaldo", "initials": "R"}], "type": "journal article", "published": "2021-10-08", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172"}, "abstract": "The prediction of in-hospital mortality for ICU patients with COVID-19 is fundamental to treatment and resource allocation. The main purpose was to develop an easily implemented score for such prediction.\n\nThis was an observational, multicenter, development and validation study on a national critical care dataset of COVID-19 patients. A systematic literature review was performed to determine variables possibly important for COVID-19 mortality prediction. Using a logistic multivariable model with a LASSO penalty, we developed the Rapid Evaluation of Coronavirus Illness Severity (RECOILS) score and compared its performance against published scores.\n\nOur development (validation) cohort consisted of 1480 (937) adult patients from 14 (11) Dutch ICUs admitted between March 2020 and April 2021. Median age was 65 (65) years, 31% (26%) died in hospital, 74% (72%) were males, average length of ICU stay was 7.83 (10.25) days and average length of hospital stay was 15.90 (19.92) days. Age, platelets, PaO2/FiO2 ratio, pH, blood urea nitrogen, temperature, PaCO2, Glasgow Coma Scale (GCS) score measured within +/- 24 hours of ICU admission were used to develop the score. The AUROC of RECOILS score was 0.75 (CI 0.71-0.78) which was higher than that of any previously reported predictive scores (0.68 (CI 0.64-0.71), 0.61 (CI 0.58-0.66), 0.67 (CI 0.63-0.70), 0.70 (CI 0.67-0.74) for ISARIC 4C Mortality Score, SOFA, SAPS-III, and age, respectively).\n\nUsing a large dataset from multiple Dutch ICUs, we developed a predictive score for mortality of COVID-19 patients admitted to ICU, which outperformed other predictive scores reported so far.", "doi": "10.1111/aas.13991", "pmid": "34622441", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:07:16.357Z", "modified": "2021-10-10T15:07:16.414Z"}, {"entity": "publication", "iuid": "77afdca8913f4abc8f52e71eb7efce65", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/77afdca8913f4abc8f52e71eb7efce65.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/77afdca8913f4abc8f52e71eb7efce65"}}, "title": "Impacts of mild COVID-19 on elevated use of primary and specialist health care services: A nationwide register study from Norway.", "authors": [{"family": "Skyrud", "given": "Katrine Damgaard", "initials": "KD", "orcid": "0000-0001-7504-9253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa7b45c41c544ba098093febd55117c8.json"}}, {"family": "Hern\u00e6s", "given": "Kjersti Helene", "initials": "KH"}, {"family": "Telle", "given": "Kjetil Elias", "initials": "KE"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2021-10-08", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0257926", "issn-l": "1932-6203"}, "abstract": "To explore the temporal impact of mild COVID-19 on need for primary and specialist health care services.\n\nIn all adults (\u226520 years) tested for SARS-CoV-2 in Norway March 1st 2020 to February 1st 2021 (N = 1 401 922), we contrasted the monthly all-cause health care use before and up to 6 months after the test (% relative difference), for patients with a positive test for SARS-CoV-2 (non-hospitalization, i.e. mild COVID-19) and patients with a negative test (no COVID-19).\n\nWe found a substantial short-term elevation in primary care use in all age groups, with men generally having a higher relative increase (men 20-44 years: 522%, 95%CI = 509-535, 45-69 years: 439%, 95%CI = 426-452, \u226570 years: 199%, 95%CI = 180-218) than women (20-44 years: 342, 95%CI = 334-350, 45-69 years = 375, 95%CI = 365-385, \u226570 years: 156%, 95%CI = 141-171) at 1 month following positive test. At 2 months, this sex difference was less pronounced, with a (20-44 years: 21%, 95%CI = 13-29, 45-69 years = 38%, 95%CI = 30-46, \u226570 years: 15%, 95%CI = 3-28) increase in primary care use for men, and a (20-44 years: 30%, 95%CI = 24-36, 45-69 years = 57%, 95%CI = 50-64, \u226570 years: 14%, 95%CI = 4-24) increase for women. At 3 months after test, only women aged 45-70 years still had an increased primary care use (14%, 95%CI = 7-20). The increase was due to respiratory- and general/unspecified conditions. We observed no long-term (4-6 months) elevation in primary care use, and no elevation in specialist care use.\n\nMild COVID-19 gives an elevated need for primary care that vanishes 2-3 months after positive test. Middle-aged women had the most prolonged increased primary care use.", "doi": "10.1371/journal.pone.0257926", "pmid": "34624023", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-20514"}], "notes": [], "created": "2021-10-10T15:04:07.839Z", "modified": "2021-10-10T15:04:07.870Z"}, {"entity": "publication", "iuid": "e63147ae2ad5461fab8c3c22dd457a15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e63147ae2ad5461fab8c3c22dd457a15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e63147ae2ad5461fab8c3c22dd457a15"}}, "title": "Depression and anxiety disorders during the COVID-19 pandemic: knowns and unknowns.", "authors": [{"family": "Taquet", "given": "Maxime", "initials": "M"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}, {"family": "Harrison", "given": "Paul J", "initials": "PJ"}], "type": "journal article", "published": "2021-10-08", "journal": {"title": "Lancet", "issn": "1474-547X", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(21)02221-2", "pmid": "34634251", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)02221-2"}], "notes": [], "created": "2021-10-21T05:40:59.740Z", "modified": "2021-10-21T05:40:59.753Z"}, {"entity": "publication", "iuid": "f1d72e38164244329f331bc86c438bb8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1d72e38164244329f331bc86c438bb8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1d72e38164244329f331bc86c438bb8"}}, "title": "Risk and protective factors, stressors, and symptoms of adjustment disorder during the COVID-19 pandemic - First results of the ESTSS COVID-19 pan-European ADJUST study.", "authors": [{"family": "Lotzin", "given": "Annett", "initials": "A", "orcid": "0000-0002-2834-8047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/414bdffc7c514b68ad7b342cd97121fa.json"}}, {"family": "Krause", "given": "Linda", "initials": "L"}, {"family": "Acquarini", "given": "Elena", "initials": "E"}, {"family": "Ajdukovic", "given": "Dean", "initials": "D"}, {"family": "Ardino", "given": "Vittoria", "initials": "V"}, {"family": "Arnberg", "given": "Filip", "initials": "F", "orcid": "0000-0002-1317-2093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b82329ec9cc545ee98bf639481323581.json"}}, {"family": "B\u00f6ttche", "given": "Maria", "initials": "M"}, {"family": "Bragesj\u00f6", "given": "Maria", "initials": "M", "orcid": "0000-0003-2246-3842", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/abec108719f641bf9fe4d0b13d62e327.json"}}, {"family": "Dragan", "given": "Ma\u0142gorzata", "initials": "M", "orcid": "0000-0001-8221-2012", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6abe40fed044419da5ab35e198fbacf8.json"}}, {"family": "Figueiredo-Braga", "given": "Margarida", "initials": "M"}, {"family": "Gelezelyte", "given": "Odeta", "initials": "O"}, {"family": "Grajewski", "given": "Piotr", "initials": "P"}, {"family": "Anastassiou-Hadjicharalambous", "given": "Xenia", "initials": "X"}, {"family": "Javakhishvili", "given": "Jana Darejan", "initials": "JD"}, {"family": "Kazlauskas", "given": "Evaldas", "initials": "E", "orcid": "0000-0002-6654-6220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/325ffed05ee04a7fb3aefc3dd9e168e1.json"}}, {"family": "Lenferink", "given": "Lonneke", "initials": "L", "orcid": "0000-0003-1329-6413", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d757067e8b284b5eac977e0dfd923967.json"}}, {"family": "Lioupi", "given": "Chrysanthi", "initials": "C"}, {"family": "Lueger-Schuster", "given": "Brigitte", "initials": "B", "orcid": "0000-0003-0784-8437", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e96be3831b3e43ed9980bdf9f8853899.json"}}, {"family": "Tsiskarishvili", "given": "Lela", "initials": "L"}, {"family": "Mooren", "given": "Trudy", "initials": "T"}, {"family": "Sales", "given": "Luisa", "initials": "L"}, {"family": "Stevanovic", "given": "Aleksandra", "initials": "A"}, {"family": "Zrnic", "given": "Irina", "initials": "I"}, {"family": "Sch\u00e4fer", "given": "Ingo", "initials": "I", "orcid": "0000-0002-9711-3559", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a082abe10d34bbbb8d3461dbf058cfd.json"}}], "type": "journal article", "published": "2021-10-07", "journal": {"title": "Eur J Psychotraumatol", "issn": "2000-8066", "volume": "12", "issue": "1", "pages": "1964197", "issn-l": null}, "abstract": "The COVID-19 pandemic exposes individuals to multiple stressors, such as quarantine, physical distancing, job loss, risk of infection, and loss of loved ones. Such a complex array of stressors potentially lead to symptoms of adjustment disorder.\n\nThis cross-sectional exploratory study examined relationships between risk and protective factors, stressors, and symptoms of adjustment disorder during the first year of the COVID-19 pandemic.\n\nData from the first wave of the European Society of Traumatic Stress Studies (ESTSS) longitudinal ADJUST Study were used. N = 15,563 participants aged 18 years and above were recruited in eleven countries (Austria, Croatia, Georgia, Germany, Greece, Italy, Lithuania, the Netherlands, Poland, Portugal, and Sweden) from June to November 2020. Associations between risk and protective factors (e.g. gender, diagnosis of a mental health disorder), stressors (e.g. fear of infection, restricted face-to-face contact), and symptoms of adjustment disorder (ADNM-8) were examined using multivariate linear regression.\n\nThe prevalence of self-reported probable adjustment disorder was 18.2%. Risk factors associated with higher levels of symptoms of adjustment disorder were female gender, older age, being at risk for severe COVID-19 illness, poorer general health status, current or previous trauma exposure, a current or previous mental health disorder, and longer exposure to COVID-19 news. Protective factors related to lower levels of symptoms of adjustment disorder were higher income, being retired, and having more face-to-face contact with loved ones or friends. Pandemic-related stressors associated with higher levels of symptoms of adjustment disorder included fear of infection, governmental crisis management, restricted social contact, work-related problems, restricted activity, and difficult housing conditions.\n\nWe identified stressors, risk, and protective factors that may help identify individuals at higher risk for adjustment disorder.", "doi": "10.1080/20008198.2021.1964197", "pmid": "34992755", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "1964197"}, {"db": "pmc", "key": "PMC8725769"}], "notes": [], "created": "2022-01-10T15:31:26.902Z", "modified": "2022-01-10T15:31:28.538Z"}, {"entity": "publication", "iuid": "5327d5834c684edc9a2a761b3d58d128", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5327d5834c684edc9a2a761b3d58d128.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5327d5834c684edc9a2a761b3d58d128"}}, "title": "Reduced ability to produce reflex-evoked neurogenic inflammation, a sign of decreased defense against COVID-19 infection?", "authors": [{"family": "Malm", "given": "Lars", "initials": "L", "orcid": "0000-0002-3408-4455", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee058659e4c64f6db787c4b9f19eec6c.json"}}], "type": "journal article", "published": "2021-10-07", "journal": {"title": "Skin Res Technol", "issn": "1600-0846", "issn-l": null}, "abstract": "A histamine skin prick test (SPT) generally evokes a wheal and a flare. The present study was initiated by an observation that histamine did not evoke a flare around a wheal in the skin of an 86-year-old man. Could that be of relevance to the findings that old men are prone to a more severe COVD-19 infection with a higher mortality than young ones?\n\nHistamine SPT was performed on the forearm of six old men, all above the age of 80. The skin reactions were photographed from above and from the side. The photographs taken from above were treated in a computer with LYYN, a program that increases color differences. With the help of ImageJ (NIH), the size relation between flare and wheal was calculated. On the photographs, taken as side views, areas, heights, and diameters of wheals were measured. Controls consisted of three groups of younger people.\n\nAmong the old men, no or only a small flare was seen. All the controls had prominent flares. Histamine SPT evoked small wheals in the group of old men as compared to young men.\n\nReduced neurogenic inflammation evoked by histamine from mast cells in blood and tissue may reduce the defense against COVID-19 infection.", "doi": "10.1111/srt.13089", "pmid": "34618975", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:24:02.582Z", "modified": "2021-10-10T15:24:12.373Z"}, {"entity": "publication", "iuid": "f6c40f5a5c124c73adee6ac3acba4ad1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6c40f5a5c124c73adee6ac3acba4ad1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6c40f5a5c124c73adee6ac3acba4ad1"}}, "title": "Quantifying the impacts of human mobility restriction on the spread of coronavirus disease 2019: an empirical analysis from 344 cities of China.", "authors": [{"family": "Tan", "given": "Jing", "initials": "J"}, {"family": "Zhao", "given": "Shao-Yang", "initials": "SY"}, {"family": "Xiong", "given": "Yi-Quan", "initials": "YQ"}, {"family": "Liu", "given": "Chun-Rong", "initials": "CR"}, {"family": "Huang", "given": "Shi-Yao", "initials": "SY"}, {"family": "Lu", "given": "Xin", "initials": "X"}, {"family": "Thabane", "given": "Lehana", "initials": "L"}, {"family": "Xie", "given": "Feng", "initials": "F"}, {"family": "Sun", "given": "Xin", "initials": "X"}, {"family": "Li", "given": "Wei-Min", "initials": "WM"}], "type": "journal article", "published": "2021-10-07", "journal": {"title": "Chin Med J (Engl)", "issn": "2542-5641", "volume": "134", "issue": "20", "pages": "2438-2446", "issn-l": null}, "abstract": "Since the outbreak of coronavirus disease 2019 (COVID-19), human mobility restriction measures have raised controversies, partly because of the inconsistent findings. An empirical study is promptly needed to reliably assess the causal effects of the mobility restriction. The purpose of this study was to quantify the causal effects of human mobility restriction on the spread of COVID-19.\n\nOur study applied the difference-in-difference (DID) model to assess the declines of population mobility at the city level, and used the log-log regression model to examine the effects of population mobility declines on the disease spread measured by cumulative or new cases of COVID-19 over time after adjusting for confounders.\n\nThe DID model showed that a continual expansion of the relative declines over time in 2020. After 4 weeks, population mobility declined by -54.81% (interquartile range, -65.50% to -43.56%). The accrued population mobility declines were associated with the significant reduction of cumulative COVID-19 cases throughout 6 weeks (ie, 1% decline of population mobility was associated with 0.72% [95% CI: 0.50%-0.93%] reduction of cumulative cases for 1 week, 1.42% 2 weeks, 1.69% 3 weeks, 1.72% 4 weeks, 1.64% 5 weeks, and 1.52% 6 weeks). The impact on the weekly new cases seemed greater in the first 4 weeks but faded thereafter. The effects on cumulative cases differed by cities of different population sizes, with greater effects seen in larger cities.\n\nPersistent population mobility restrictions are well deserved. Implementation of mobility restrictions in major cities with large population sizes may be even more important.", "doi": "10.1097/CM9.0000000000001763", "pmid": "34620748", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8654447"}, {"db": "pii", "key": "00029330-202110200-00009"}], "notes": [], "created": "2021-10-10T15:09:25.592Z", "modified": "2023-06-19T15:32:35.419Z"}, {"entity": "publication", "iuid": "588404bd37a041b58b8b940a9211a7a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/588404bd37a041b58b8b940a9211a7a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/588404bd37a041b58b8b940a9211a7a2"}}, "title": "Monetary incentives increase COVID-19 vaccinations.", "authors": [{"family": "Campos-Mercade", "given": "Pol", "initials": "P", "orcid": "0000-0002-7396-6514", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f4066be7689442009ba93911c0ec8771.json"}}, {"family": "Meier", "given": "Armando N", "initials": "AN", "orcid": "0000-0001-7977-8875", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3742dc32640c487eaee5493c1ae3432c.json"}}, {"family": "Schneider", "given": "Florian H", "initials": "FH", "orcid": "0000-0002-8406-2756", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76b238f01e6749bab5aefb7308ba056d.json"}}, {"family": "Meier", "given": "Stephan", "initials": "S", "orcid": "0000-0001-6726-9731", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d19cff065b54dea9974baeff383b788.json"}}, {"family": "Pope", "given": "Devin", "initials": "D", "orcid": "0000-0002-6567-9654", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2c1fb2cb5704cd08f6a919b071e4c4e.json"}}, {"family": "Wengstr\u00f6m", "given": "Erik", "initials": "E", "orcid": "0000-0002-1414-9055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e53ebfb55494b95911dcac8ad5e2a8b.json"}}], "type": "journal article", "published": "2021-10-07", "journal": {"title": "Science", "issn": "1095-9203", "pages": "eabm0475", "issn-l": "0036-8075"}, "abstract": "[Figure: see text].", "doi": "10.1126/science.abm0475", "pmid": "34618594", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:24:52.231Z", "modified": "2021-10-10T15:24:52.385Z"}, {"entity": "publication", "iuid": "38c7f28743fe4af18264ee231be1f617", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38c7f28743fe4af18264ee231be1f617.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38c7f28743fe4af18264ee231be1f617"}}, "title": "Cardiovascular Magnetic Resonance for Patients With COVID-19.", "authors": [{"family": "Petersen", "given": "Steffen E", "initials": "SE"}, {"family": "Friedrich", "given": "Matthias G", "initials": "MG"}, {"family": "Leiner", "given": "Tim", "initials": "T"}, {"family": "Elias", "given": "Matthew D", "initials": "MD"}, {"family": "Ferreira", "given": "Vanessa M", "initials": "VM"}, {"family": "Fenski", "given": "Maximilian", "initials": "M"}, {"family": "Flamm", "given": "Scott D", "initials": "SD"}, {"family": "Fogel", "given": "Mark", "initials": "M"}, {"family": "Garg", "given": "Ria", "initials": "R"}, {"family": "Halushka", "given": "Marc K", "initials": "MK"}, {"family": "Hays", "given": "Allison G", "initials": "AG"}, {"family": "Kawel-Boehm", "given": "Nadine", "initials": "N"}, {"family": "Kramer", "given": "Christopher M", "initials": "CM"}, {"family": "Nagel", "given": "Eike", "initials": "E"}, {"family": "Ntusi", "given": "Ntobeko A B", "initials": "NAB"}, {"family": "Ostenfeld", "given": "Ellen", "initials": "E"}, {"family": "Pennell", "given": "Dudley J", "initials": "DJ"}, {"family": "Raisi-Estabragh", "given": "Zahra", "initials": "Z"}, {"family": "Reeder", "given": "Scott B", "initials": "SB"}, {"family": "Rochitte", "given": "Carlos E", "initials": "CE"}, {"family": "Starekova", "given": "Jitka", "initials": "J"}, {"family": "Such\u00e1", "given": "Dominika", "initials": "D"}, {"family": "Tao", "given": "Qian", "initials": "Q"}, {"family": "Schulz-Menger", "given": "Jeanette", "initials": "J"}, {"family": "Bluemke", "given": "David A", "initials": "DA"}], "type": "journal article", "published": "2021-10-07", "journal": {"title": "JACC Cardiovasc Imaging", "issn": "1876-7591", "issn-l": null}, "abstract": "COVID-19 is associated with myocardial injury caused by ischemia, inflammation, or myocarditis. Cardiovascular magnetic resonance (CMR) is the noninvasive reference standard for cardiac function, structure, and tissue composition. CMR is a potentially valuable diagnostic tool in patients with COVID-19 presenting with myocardial injury and evidence of cardiac dysfunction. Although COVID-19-related myocarditis is likely infrequent, COVID-19-related cardiovascular histopathology findings have been reported in up to 48% of patients, raising the concern for long-term myocardial injury. Studies to date report CMR abnormalities in 26% to 60% of hospitalized patients who have recovered from COVID-19, including functional impairment, myocardial tissue abnormalities, late gadolinium enhancement, or pericardial abnormalities. In athletes post-COVID-19, CMR has detected myocarditis-like abnormalities. In children, multisystem inflammatory syndrome may occur 2 to 6 weeks after infection; associated myocarditis and coronary artery aneurysms are evaluable by CMR. At this time, our understanding of COVID-19-related cardiovascular involvement is incomplete, and multiple studies are planned to evaluate patients with COVID-19 using CMR. In this review, we summarize existing studies of CMR for patients with COVID-19 and present ongoing research. We also provide recommendations for clinical use of CMR for patients with acute symptoms or who are recovering from COVID-19.", "doi": "10.1016/j.jcmg.2021.08.021", "pmid": "34656482", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1936-878X(21)00688-4"}], "notes": [], "created": "2021-10-21T05:03:00.026Z", "modified": "2021-10-21T05:03:00.039Z"}, {"entity": "publication", "iuid": "41da54b6251142b5a37a2d2c195e3744", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41da54b6251142b5a37a2d2c195e3744.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41da54b6251142b5a37a2d2c195e3744"}}, "title": "COVID-19 and the ageing workforce: global perspectives on needs and solutions across 15 countries.", "authors": [{"family": "Pit", "given": "Sabrina", "initials": "S", "orcid": "0000-0003-2410-0703", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10d28d10de7246d892a63c541aeb4be0.json"}}, {"family": "Fisk", "given": "Malcolm", "initials": "M"}, {"family": "Freihaut", "given": "Winona", "initials": "W"}, {"family": "Akintunde", "given": "Fashola", "initials": "F"}, {"family": "Aloko", "given": "Bamidele", "initials": "B"}, {"family": "Berge", "given": "Britta", "initials": "B"}, {"family": "Burmeister", "given": "Anne", "initials": "A"}, {"family": "Ciac\u00e2ru", "given": "Adriana", "initials": "A"}, {"family": "Deller", "given": "J\u00fcrgen", "initials": "J"}, {"family": "Dulmage", "given": "Rae", "initials": "R"}, {"family": "Han", "given": "Tae Hwa", "initials": "TH"}, {"family": "Hao", "given": "Qiang", "initials": "Q"}, {"family": "Honeyman", "given": "Peter", "initials": "P"}, {"family": "Huber", "given": "Peter C", "initials": "PC"}, {"family": "Linner", "given": "Thomas", "initials": "T"}, {"family": "Lundberg", "given": "Stefan", "initials": "S"}, {"family": "Nwamara", "given": "Mofoluwaso", "initials": "M"}, {"family": "Punpuing", "given": "Kamolpun", "initials": "K"}, {"family": "Schramm", "given": "Jennifer", "initials": "J"}, {"family": "Yamada", "given": "Hajime", "initials": "H"}, {"family": "Yap", "given": "Jason C H", "initials": "JCH"}], "type": "letter", "published": "2021-10-07", "journal": {"title": "Int J Equity Health", "issn": "1475-9276", "volume": "20", "issue": "1", "pages": "221", "issn-l": null}, "abstract": "COVID-19 has a direct impact on the employment of older people. This adds to the challenge of ageism. The World Health Organization has started a worldwide campaign to combat ageism and has called for more research and evidence-based strategies that have the potential to be scaled up. This study specifically aims to identify solutions to combat the adverse effects of COVID-19 on the global ageing workforce.\n\nWe present 15 case studies from different countries and report on what those countries are doing or not doing to address the impact of COVID-19 on ageing workers.\n\nWe provide examples of how COVID-19 influences older people's ability to work and stay healthy, and offer case studies of what governments, organizations or individuals can do to help ensure older people can obtain, maintain and, potentially, expand their current work. Case studies come from Australia, Austria, Canada, China, Germany, Israel, Japan, Nigeria, Romania, Singapore, Sweden, South Korea, Thailand, United Kingdom (UK), and the United States (US). Across the countries, the impact of COVID-19 on older workers is shown as widening inequalities. A particular challenge has arisen because of a large proportion of older people, often with limited education and working in the informal sector within rural areas, e.g. in Nigeria, Thailand and China. Remedies to the particular disadvantage experienced by older workers in the context of COVID are presented. These range from funding support to encouraging business continuity, innovative product and service developments, community action, new business models and localized, national and international actions. The case studies can be seen as frequently fitting within strategies that have been proven to work in reducing ageism within the workplace. They include policy and laws that have increased benefits to workers during lockdowns (most countries); educational activities such as coaching seniorpreneurship (e,g, Australia); intergenerational contact interventions such as younger Thai people who moved back to rural areas and sharing their digital knowledge with older people and where older people reciprocate by teaching the younger people farming knowledge.\n\nGlobal sharing of this knowledge among international, national and local governments and organizations, businesses, policy makers and health and human resources experts will further understanding of the issues that are faced by older workers. This will facilitate the replication or scalability of solutions as called for in the WHO call to combat ageism in 2021. We suggest that policy makers, business owners, researchers and international organisations build on the case studies by investing in evidence-based strategies to create inclusive workplaces. Such action will thus help to challenge ageism, reduce inequity, improve business continuity and add to the quality of life of older workers.", "doi": "10.1186/s12939-021-01552-w", "pmid": "34620164", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12939-021-01552-w"}], "notes": [], "created": "2021-10-10T15:11:05.307Z", "modified": "2021-10-10T15:11:19.877Z"}, {"entity": "publication", "iuid": "d6b5dfe0a80a42fda6b2fec7020b8aa9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d6b5dfe0a80a42fda6b2fec7020b8aa9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d6b5dfe0a80a42fda6b2fec7020b8aa9"}}, "title": "Antigen receptor stimulation drives selection against pathogenic mtDNA variants that dysregulate lymphocyte responses", "authors": [{"family": "Zhang", "given": "Jingdian", "initials": "J", "orcid": "0000-0002-5685-8386", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/139b5809061346d39e002c77816fde6a.json"}}, {"family": "Koolmeister", "given": "Camilla", "initials": "C", "orcid": "0000-0002-4052-3442", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4297e6da55f4b3c8fd076fa713feb10.json"}}, {"family": "Han", "given": "Jinming", "initials": "J", "orcid": "0000-0002-6084-3275", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb80d9babf4c44ba9a253e9d4fdd0ce2.json"}}, {"family": "Filograna", "given": "Roberta", "initials": "R", "orcid": "0000-0002-6581-9426", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7a885a6fd994c0fb9be5380566db317.json"}}, {"family": "Hanke", "given": "Leo", "initials": "L", "orcid": "0000-0001-5514-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a35f10de4f2e4aee98278f6ab845613d.json"}}, {"family": "\u00c0dori", "given": "Monika", "initials": "M"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ", "orcid": "0000-0002-0227-5636", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a612a313d5874131ba64d9811a5d4a08.json"}}, {"family": "Teifel", "given": "Sina", "initials": "S"}, {"family": "Liu", "given": "Yong", "initials": "Y"}, {"family": "Harris", "given": "Robert A", "initials": "RA", "orcid": "0000-0003-4990-509X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/281bc302a3134c2288944689057586b0.json"}}, {"family": "Murrell", "given": "Ben", "initials": "B", "orcid": "0000-0002-0393-4445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60dac9ecf84d4eb3b90fb4ee1298bc52.json"}}, {"family": "Mcinerney", "given": "Gerald", "initials": "G", "orcid": "0000-0003-2257-7241", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7770437d845444a8a07865bf5b62fab0.json"}}, {"family": "Aoun", "given": "Mike", "initials": "M", "orcid": "0000-0002-7814-3787", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11060fd375054a4fa3038f0a46ad5c94.json"}}, {"family": "B\u00e4ckdahl", "given": "Liselotte", "initials": "L"}, {"family": "Holmdahl", "given": "Rikard", "initials": "R", "orcid": "0000-0002-4969-2576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/583b21b385a747a5a75695c08847b61b.json"}}, {"family": "Pekalski", "given": "Marcin", "initials": "M", "orcid": "0000-0001-7623-4370", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d12f48c2a2d4c6ea50af0f51e90c83b.json"}}, {"family": "Wedell", "given": "Anna", "initials": "A", "orcid": "0000-0002-2612-6301", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a2177a737cb4fd8b49af5af451a7a3f.json"}}, {"family": "Engvall", "given": "Martin", "initials": "M", "orcid": "0000-0002-8339-3545", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4eb7b09c59d48579d33248024846c16.json"}}, {"family": "Wredenberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-2500-6121", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58d21281196345539d7c55bc4e778c24.json"}}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB", "orcid": "0000-0001-7255-9047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/891aa9ca3f604b7396a14d65a33c2187.json"}}, {"family": "Dopico", "given": "Xaquin Castro", "initials": "XC", "orcid": "0000-0002-9005-6774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/354c91b234fd4a039f85c13e7e4209c1.json"}}, {"family": "Rorbach", "given": "Joanna", "initials": "J", "orcid": "0000-0002-2891-2840", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ddfd02a56dc4c43ac6e01c113c19874.json"}}], "type": "posted-content", "published": "2021-10-07", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.10.05.21264464", "pmid": null, "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null, "Funder: H2020": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:42:30.709Z", "modified": "2021-10-26T18:42:31.160Z"}, {"entity": "publication", "iuid": "e441333fa3164d2f8f0112b4397e2684", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e441333fa3164d2f8f0112b4397e2684.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e441333fa3164d2f8f0112b4397e2684"}}, "title": "Androgen deprivation therapy and excess mortality in men with prostate cancer during the initial phase of the COVID-19 pandemic.", "authors": [{"family": "Gedeborg", "given": "Rolf", "initials": "R", "orcid": "0000-0002-8850-7863", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/234ef51ed7854efb8bbadc3ce35bf7d9.json"}}, {"family": "Styrke", "given": "Johan", "initials": "J"}, {"family": "Loeb", "given": "Stacy", "initials": "S"}, {"family": "Garmo", "given": "Hans", "initials": "H"}, {"family": "Stattin", "given": "P\u00e4r", "initials": "P", "orcid": "0000-0002-8306-0687", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/504d868e215c41ab8a75cb2e6cd289b8.json"}}], "type": "journal article", "published": "2021-10-07", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0255966", "issn-l": "1932-6203"}, "abstract": "Men have a higher risk of death from COVID-19 than women and androgens facilitate entrance of the SARS-CoV-2 virus into respiratory epithelial cells. Thus, androgen deprivation therapy may reduce infection rates and improve outcomes for COVID-19. In the spring of 2020, Sweden was highly affected by COVID-19. The aim was to estimate the impact of androgen deprivation therapy on mortality from COVID-19 in men with prevalent prostate cancer by comparing all-cause mortality in the spring of 2020 to that in previous years.\n\nUsing the Prostate Cancer data Base Sweden all men with prostate cancer on March 1 each year in 2015-2020 were followed until June 30 the same year. Exposure to androgen deprivation therapy was ascertained from filled prescriptions for bicalutamide monotherapy, gonadotropin-releasing hormone agonists (GnRH), or bilateral orchidectomy.\n\nA total of 9,822 men died in March-June in the years 2015-2020, of whom 5,034 men were on androgen deprivation therapy. There was an excess mortality in 2020 vs previous years in all men. The crude relative mortality rate ratio for 2020 vs 2015-2019 was 0.93 (95% confidence interval (CI) 0.83 to 1.04) in men on GnRH, and 0.90 (95% CI 0.78 to 1.05) in men on bicalutamide monotherapy. After multivariable adjustment these ratios were attenuated to 1.00 (95% CI 0.89 to 1.12) and 0.97 (95% CI 0.84 to 1.12), respectively. When restricting the analysis to the regions with the highest incidence of COVID-19 or to the time period between 2 April to 10 June when mortality in 2020 was increased >30% compared to previous years, the results were similar to the main analysis.\n\nIn this large national population-based cohort of men with prevalent prostate cancer, there was no clear evidence in support for an effect of androgen deprivation therapy on COVID-19 mortality.", "doi": "10.1371/journal.pone.0255966", "pmid": "34618806", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-04843"}], "notes": [], "created": "2021-10-10T15:24:32.122Z", "modified": "2021-10-10T15:24:32.184Z"}, {"entity": "publication", "iuid": "6366e1e82162434eb530528760477605", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6366e1e82162434eb530528760477605.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6366e1e82162434eb530528760477605"}}, "title": "A cell-free high throughput assay for assessment of SARS-CoV-2 neutralizing antibodies.", "authors": [{"family": "Mravinacova", "given": "Sara", "initials": "S"}, {"family": "J\u00f6nsson", "given": "Malin", "initials": "M"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Yousef", "given": "Jamil", "initials": "J"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Tegel", "given": "Hanna", "initials": "H"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Hober", "given": "Sophia", "initials": "S"}], "type": "journal article", "published": "2021-10-07", "journal": {"title": "N Biotechnol", "issn": "1876-4347", "issn-l": null, "volume": "66", "issue": null, "pages": "46-52"}, "abstract": "Highly accurate serological tests are key to assessing the prevalence of SARS-CoV-2 antibodies and the level of immunity in the population. This is important to predict the current and future status of the pandemic. With the recent emergence of new and more infectious SARS-CoV-2 variants, assays allowing for high throughput analysis of antibodies able to neutralize SARS-CoV-2 become even more important. Here, we report the development and validation of a robust, high throughput method, which enables the assessment of antibodies inhibiting the binding between the SARS-CoV-2 spike protein and angiotensin converting enzyme 2 (ACE2). The assay uses recombinantly produced spike-f and ACE2 and is performed in a bead array format, which allows analysis of up to 384 samples in parallel per instrument over seven hours, demanding only one hour of manual handling. The method is compared to a microneutralization assay utilising live SARS-CoV-2 and is shown to deliver highly correlating data. Further, a comparison with a serological method that measures all antibodies recognizing the spike protein shows that this type of assessment provides important insights into the neutralizing efficiency of the antibodies, especially for individuals with low antibody levels. This method can be an important and valuable tool for large-scale assessment of antibody-based neutralization, including neutralization of new spike variants that might emerge.", "doi": "10.1016/j.nbt.2021.10.002", "pmid": "34628049", "labels": {"Research Area: High-throughput and high-content serology": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Research Area: Host cell systems biology and targets": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: H2020": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1871-6784(21)00091-1"}, {"db": "pmc", "key": "PMC8495044"}], "notes": [], "created": "2021-10-11T17:45:54.123Z", "modified": "2021-11-18T16:29:35.546Z"}, {"entity": "publication", "iuid": "4a866576db52433b8a76b49766800900", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4a866576db52433b8a76b49766800900.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4a866576db52433b8a76b49766800900"}}, "title": "Social Jetlag Changes During the COVID-19 Pandemic as a Predictor of Insomnia - A Multi-National Survey Study.", "authors": [{"family": "Brand\u00e3o", "given": "Luiz Eduardo Mateus", "initials": "LEM", "orcid": "0000-0002-8672-7870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5d4c5e8bc704f2cb500e28e657ea315.json"}}, {"family": "Martikainen", "given": "Teemu", "initials": "T", "orcid": "0000-0003-2399-5138", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f163f4fee7514093a8fa354b45a137c8.json"}}, {"family": "Merikanto", "given": "Ilona", "initials": "I", "orcid": "0000-0002-1222-6678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50ed32f3146e4c0aa13e934d46eeb4af.json"}}, {"family": "Holzinger", "given": "Brigitte", "initials": "B", "orcid": "0000-0001-5385-4091", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/179fc564b66746d2a981082e5411d762.json"}}, {"family": "Morin", "given": "Charles M", "initials": "CM", "orcid": "0000-0002-8649-8895", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd42cb2cf7194992b7c06fac723e6ceb.json"}}, {"family": "Espie", "given": "Colin A", "initials": "CA", "orcid": "0000-0002-1294-8734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60482d2788b1405fb87b71442f703529.json"}}, {"family": "Bolstad", "given": "Courtney J", "initials": "CJ", "orcid": "0000-0003-2297-2778", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f47da3539dc4c0c95abe747ddd2fb55.json"}}, {"family": "Leger", "given": "Damien", "initials": "D", "orcid": "0000-0003-1168-480X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2cf778dd1ed9418bb0c182347f1a0355.json"}}, {"family": "Chung", "given": "Frances", "initials": "F", "orcid": "0000-0001-9576-3606", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed55f48b6d8e400b8fd2c591a738260a.json"}}, {"family": "Plazzi", "given": "Giuseppe", "initials": "G", "orcid": "0000-0002-1051-0472", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1a913222e004ad088535b1a251c8b7a.json"}}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y", "orcid": "0000-0003-0683-6506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/630f66dea3ce4ff2afe3c46f7827355b.json"}}, {"family": "Matsui", "given": "Kentaro", "initials": "K", "orcid": "0000-0003-4538-5381", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9e5535bdd6f48d79c36d3170c28f67c.json"}}, {"family": "De Gennaro", "given": "Luigi", "initials": "L", "orcid": "0000-0003-3613-6631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e700e607f114414dba66aa366e3158b6.json"}}, {"family": "Sieminski", "given": "Mariusz", "initials": "M", "orcid": "0000-0001-8219-2912", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f92e908212f4d859cb42261a43c47c2.json"}}, {"family": "Nadorff", "given": "Michael R", "initials": "MR"}, {"family": "Chan", "given": "Ngan Yin", "initials": "NY", "orcid": "0000-0002-3009-3565", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0c796d43e5947b6890322603ad7a318.json"}}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK", "orcid": "0000-0002-5745-5474", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bbe4815f36d48959f5e81a5cf650088.json"}}, {"family": "Mota-Rolim", "given": "S\u00e9rgio Arthuro", "initials": "SA", "orcid": "0000-0003-0196-5421", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/345ba991c90a4c8689f51366dfbeba54.json"}}, {"family": "Inoue", "given": "Yuichi", "initials": "Y", "orcid": "0000-0001-7414-9017", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cd6cb8358f04e8c9c11e1ecd0f03a58.json"}}, {"family": "Partinen", "given": "Markku", "initials": "M", "orcid": "0000-0002-8182-9368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7920bcc4716848f7bd1cb89c8bdd0d5a.json"}}, {"family": "Benedict", "given": "Christian", "initials": "C", "orcid": "0000-0002-8911-4068", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a61aee14ada46ce968c40c652ac72df.json"}}, {"family": "Bjorvatn", "given": "Bjorn", "initials": "B", "orcid": "0000-0001-7051-745X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b72d97a35fa4590b5d05f0fd3524f2e.json"}}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-9052-8372", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36e153ded210463a84153370c34fa843.json"}}], "type": "journal article", "published": "2021-10-06", "journal": {"title": "Nat Sci Sleep", "issn": "1179-1608", "volume": "13", "pages": "1711-1722", "issn-l": null}, "abstract": "Lifestyle and work habits have been drastically altered by restrictions due to the COVID-19 pandemic. Whether the associated changes in sleep timing modulate the risk of suffering from symptoms of insomnia, the most prevalent sleep disorder, is however incompletely understood. Here, we evaluate the association between the early pandemic-associated change in 1) the magnitude of social jetlag (SJL) - ie, the difference between sleep timing on working vs free days - and 2) symptoms of insomnia.\n\nA total of 14,968 anonymous participants (mean age: 40 years; 64% females) responded to a standardized internet-based survey distributed across 14 countries. Using logistic multivariate regression, we examined the association between the degree of social jetlag and symptoms of insomnia, controlling for important confounders like social restriction extension, country specific COVID-19 severity and psychological distress, for example.\n\nIn response to the pandemic, participants reported later sleep timing, especially during workdays. Most participants (46%) exhibited a reduction in their SJL, whereas 20% increased it; and 34% reported no change in SJL. Notably, we found that both increased and decreased SJL, as a result of the COVID-19 pandemic, were associated with later sleep midpoint (indicating a later chronotype) as well as more recurrent and moderate-to-severe symptoms of insomnia (about 23-54% higher odds ratio than subjects with unchanged SJL). Primarily those with reduced SJL shifted their bedtimes to a later timepoint, compared with those without changes in SJL.\n\nOur findings offer important insights into how self-reported changes to the stability of sleep/wake timing, as reflected by changes in SJL, can be a critical marker of the risk of experiencing insomnia-related symptoms - even when individuals manage to reduce their social jetlag. These findings emphasize the clinical importance of analyzing sleep-wake regularity.", "doi": "10.2147/NSS.S327365", "pmid": "34675720", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "327365"}, {"db": "pmc", "key": "PMC8502537"}], "notes": [], "created": "2021-10-26T18:11:31.595Z", "modified": "2021-10-26T18:11:32.221Z"}, {"entity": "publication", "iuid": "a124c47fcd2d40ed9743d00c5abf6747", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a124c47fcd2d40ed9743d00c5abf6747.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a124c47fcd2d40ed9743d00c5abf6747"}}, "title": "Self-Transcendence as a Buffer Against COVID-19 Suffering: The Development and Validation of the Self-Transcendence Measure-B.", "authors": [{"family": "Wong", "given": "Paul T P", "initials": "PTP"}, {"family": "Arslan", "given": "G\u00f6kmen", "initials": "G"}, {"family": "Bowers", "given": "Victoria L", "initials": "VL"}, {"family": "Peacock", "given": "Edward J", "initials": "EJ"}, {"family": "Kjell", "given": "Oscar Nils Erik", "initials": "ONE"}, {"family": "Ivtzan", "given": "Itai", "initials": "I"}, {"family": "Lomas", "given": "Tim", "initials": "T"}], "type": "journal article", "published": "2021-10-06", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "12", "issue": null, "pages": "648549"}, "abstract": "The age of COVID-19 calls for a different approach toward global well-being and flourishing through the transcendence suffering as advocated by existential positive psychology. In the present study, we primarily explained what self-transcendence is and why it represents the most promising path for human beings to flourish through the transformation of suffering in a difficult and uncertain world. After reviewing the literature on self-transcendence experiences, we concluded that the model of self-transcendence presented by Frankl is able to integrate both of the characteristics associated with self-transcendence. Afterward, we discussed how the self-transcendence paradigm proposed by Wong, an extension of the model by Frankl, may help awaken our innate capacity for connections with the true self, with others, and with God or something larger than oneself. We presented self-transcendence as a less-traveled but more promising route to achieve personal growth and mental health in troubled times. Finally, we presented the history of the development and psychometrics of the Self-Transcendence Measure-Brief (STM-B) and reported the empirical evidence that self-transcendence served as a buffer against COVID-19 suffering. The presented data in the current study suggested that the best way to overcome pandemic suffering and mental health crises is to cultivate self-transcendence.", "doi": "10.3389/fpsyg.2021.648549", "pmid": "34690853", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8527188"}], "notes": [], "created": "2021-10-26T18:20:37.527Z", "modified": "2022-02-17T10:26:17.592Z"}, {"entity": "publication", "iuid": "320201f5551b4ad4b0fe9d47ac3d3376", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/320201f5551b4ad4b0fe9d47ac3d3376.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/320201f5551b4ad4b0fe9d47ac3d3376"}}, "title": "Experiences of Renal Replacement Therapy Delivery in Swedish Intensive Care Units during the COVID-19 Pandemic.", "authors": [{"family": "Hertzberg", "given": "Daniel", "initials": "D"}, {"family": "Renberg", "given": "M\u00e5rten", "initials": "M"}, {"family": "Nyman", "given": "Jesper", "initials": "J"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "Rimes Stigare", "given": "Claire", "initials": "C"}], "type": "journal article", "published": "2021-10-06", "journal": {"title": "Blood Purif", "issn": "1421-9735", "pages": "1-6", "issn-l": null}, "abstract": "The COVID-19 pandemic led to a rapidly increased demand for intensive care unit (ICU) and renal replacement therapy (RRT) worldwide. RRT delivery was threatened by a lack of specially trained staff and equipment. We investigated how the first wave of COVID-19 affected RRT delivery in Swedish ICUs.\n\nAn Internet-based questionnaire was sent to ICU lead physicians which included quantitative and qualitative questions regarding RRT demand, equipment availability, and use of continuous renal replacement therapy (CRRT), intermittent haemodialysis (IHD), and peritoneal dialysis (PD) during spring 2020.\n\nTwenty-five ICUs responded and these treated 64% of COVID-19 ICU patients in Sweden. ICU capacity increased by 292% (IQR 171-347%). Median peak capacity was reached during the 18th week of the year. RRT use increased overall by 133% and in Stockholm by 188%. 36% of units sequestered CRRT machines. IHD was used in 68% and PD in 12% of ICUs. RRT fluid and filter shortages were experienced by 45% and 33% of wards, respectively; consequently, prescription alterations were made by 24% of ICUs. Calcium solution shortages were reported in 12% of units that led to citrate protocol changes. Staffing shortages resulted in RRT sometimes being delivered by non-RRT-trained staff, safety incidents relating to this occurred, although no patient harm was reported.\n\nDuring the first wave of the COVID-19 pandemic, RRT demand increased extensively causing staff and equipment shortages, altered CRRT protocols, and increased use of IHD and PD. The impact on patient outcomes should be assessed to effectively plan for further surge capacity RRT demand.", "doi": "10.1159/000519261", "pmid": "34614497", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "000519261"}], "notes": [], "created": "2021-10-10T15:25:47.568Z", "modified": "2021-10-10T15:25:47.591Z"}, {"entity": "publication", "iuid": "2325938297904701a52685931800a279", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2325938297904701a52685931800a279.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2325938297904701a52685931800a279"}}, "title": "Distance learning in higher education during COVID-19: The role of basic psychological needs and intrinsic motivation for persistence and procrastination-a multi-country study.", "authors": [{"family": "Pelikan", "given": "Elisabeth R", "initials": "ER", "orcid": "0000-0003-2317-9237", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7015e04c057e420ab0b089a179feaed0.json"}}, {"family": "Korlat", "given": "Selma", "initials": "S", "orcid": "0000-0001-5719-5222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb333a31bbcf430c8bc4e88aad915429.json"}}, {"family": "Reiter", "given": "Julia", "initials": "J", "orcid": "0000-0002-7451-9441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d718a2b09a844ecac9d63f048732d91.json"}}, {"family": "Holzer", "given": "Julia", "initials": "J", "orcid": "0000-0002-0029-3291", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb443253e26f454589e051a5ab7cc115.json"}}, {"family": "Mayerhofer", "given": "Martin", "initials": "M", "orcid": "0000-0002-2978-4385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0477f9f8f9904dc6b257c5f6d31386fb.json"}}, {"family": "Schober", "given": "Barbara", "initials": "B"}, {"family": "Spiel", "given": "Christiane", "initials": "C"}, {"family": "Hamzallari", "given": "Oriola", "initials": "O", "orcid": "0000-0002-1154-7779", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7cfac7d82c94ba8833a7aa3fea2c1f0.json"}}, {"family": "Uka", "given": "Ana", "initials": "A", "orcid": "0000-0002-9039-8504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/813556c4adc8489cab0cfd710d42b0b3.json"}}, {"family": "Chen", "given": "Jiarui", "initials": "J"}, {"family": "V\u00e4lim\u00e4ki", "given": "Maritta", "initials": "M"}, {"family": "Puhari\u0107", "given": "Zrinka", "initials": "Z"}, {"family": "Anusionwu", "given": "Kelechi Evans", "initials": "KE", "orcid": "0000-0002-2946-076X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c0f0fc7278c448fb35962ececa3a0ed.json"}}, {"family": "Okocha", "given": "Angela Nkem", "initials": "AN", "orcid": "0000-0002-8668-6183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4fc8fcd5e4754cfeb7f671155089bc97.json"}}, {"family": "Zabrodskaja", "given": "Anastassia", "initials": "A"}, {"family": "Salmela-Aro", "given": "Katariina", "initials": "K"}, {"family": "K\u00e4ser", "given": "Udo", "initials": "U"}, {"family": "Schultze-Krumbholz", "given": "Anja", "initials": "A"}, {"family": "Wachs", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-2787-6646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b86f9438ea894681afe3ed3b75b93c91.json"}}, {"family": "Fri\u00f0riksson", "given": "Finnur", "initials": "F"}, {"family": "Gunn\u00fe\u00f3rsd\u00f3ttir", "given": "Herm\u00edna", "initials": "H"}, {"family": "H\u00f6ller", "given": "Yvonne", "initials": "Y"}, {"family": "Aoyama", "given": "Ikuko", "initials": "I"}, {"family": "Ieshima", "given": "Akihiko", "initials": "A", "orcid": "0000-0001-6423-375X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5df4f3f0e605406fbe93edba3abfaa49.json"}}, {"family": "Toda", "given": "Yuichi", "initials": "Y"}, {"family": "Konjufca", "given": "Jon", "initials": "J"}, {"family": "Llullaku", "given": "Njomza", "initials": "N"}, {"family": "Gedutien\u0117", "given": "Reda", "initials": "R"}, {"family": "Borg Axisa", "given": "Glorianne", "initials": "G"}, {"family": "Avirovic Bundalevska", "given": "Irena", "initials": "I", "orcid": "0000-0002-1609-000X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7b03d30dc8a437789778827cbdc9bc2.json"}}, {"family": "Keskinova", "given": "Angelka", "initials": "A", "orcid": "0000-0002-3698-0501", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a67f06d40fd042bd8d7ecbfdff33933f.json"}}, {"family": "Radulovic", "given": "Makedonka", "initials": "M", "orcid": "0000-0002-3753-1521", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9da2b609843042ada1ed1f22296e1d08.json"}}, {"family": "Lewandowska-Walter", "given": "Aleksandra", "initials": "A"}, {"family": "Micha\u0142ek-Kwiecie\u0144", "given": "Justyna", "initials": "J"}, {"family": "Plichta", "given": "Piotr", "initials": "P"}, {"family": "Py\u017calski", "given": "Jacek", "initials": "J", "orcid": "0000-0001-5817-276X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8072f973e24740f88e300907e166d361.json"}}, {"family": "Walter", "given": "Natalia", "initials": "N", "orcid": "0000-0002-2347-9312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a00af7a0664848bbbf2d9356924d8aca.json"}}, {"family": "Cautisanu", "given": "Cristina", "initials": "C", "orcid": "0000-0002-4457-1185", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/308dce29591748d087647da56445b1ca.json"}}, {"family": "Voda", "given": "Ana Iolanda", "initials": "AI"}, {"family": "Gao", "given": "Shang", "initials": "S", "orcid": "0000-0002-3722-6797", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/045bf868b2e14614985d01eab4a1a021.json"}}, {"family": "Islam", "given": "Sirajul", "initials": "S", "orcid": "0000-0002-7907-6037", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e05dfe6ec254efe8e7f98a35ab5728d.json"}}, {"family": "Wistrand", "given": "Kai", "initials": "K", "orcid": "0000-0002-1394-3783", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e776d6c1c4b4cdaa5452120b388678c.json"}}, {"family": "Wright", "given": "Michelle F", "initials": "MF"}, {"family": "L\u00fcftenegger", "given": "Marko", "initials": "M", "orcid": "0000-0001-8112-976X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f123b600b20342719f0c25cce9974e60.json"}}], "type": "journal article", "published": "2021-10-06", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0257346", "issn-l": "1932-6203"}, "abstract": "Due to the COVID-19 pandemic, higher educational institutions worldwide switched to emergency distance learning in early 2020. The less structured environment of distance learning forced students to regulate their learning and motivation more independently. According to self-determination theory (SDT), satisfaction of the three basic psychological needs for autonomy, competence and social relatedness affects intrinsic motivation, which in turn relates to more active or passive learning behavior. As the social context plays a major role for basic need satisfaction, distance learning may impair basic need satisfaction and thus intrinsic motivation and learning behavior. The aim of this study was to investigate the relationship between basic need satisfaction and procrastination and persistence in the context of emergency distance learning during the COVID-19 pandemic in a cross-sectional study. We also investigated the mediating role of intrinsic motivation in this relationship. Furthermore, to test the universal importance of SDT for intrinsic motivation and learning behavior under these circumstances in different countries, we collected data in Europe, Asia and North America. A total of N = 15,462 participants from Albania, Austria, China, Croatia, Estonia, Finland, Germany, Iceland, Japan, Kosovo, Lithuania, Poland, Malta, North Macedonia, Romania, Sweden, and the US answered questions regarding perceived competence, autonomy, social relatedness, intrinsic motivation, procrastination, persistence, and sociodemographic background. Our results support SDT's claim of universality regarding the relation between basic psychological need fulfilment, intrinsic motivation, procrastination, and persistence. However, whereas perceived competence had the highest direct effect on procrastination and persistence, social relatedness was mainly influential via intrinsic motivation.", "doi": "10.1371/journal.pone.0257346", "pmid": "34613978", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-10408"}, {"db": "pmc", "key": "PMC8494346"}], "notes": [], "created": "2021-10-10T15:26:30.528Z", "modified": "2021-10-10T15:26:40.706Z"}, {"entity": "publication", "iuid": "68ef25c5e76d44af802d7349a8e8157c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68ef25c5e76d44af802d7349a8e8157c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68ef25c5e76d44af802d7349a8e8157c"}}, "title": "COVID-19 vaccination in patients with heart failure: a position paper of the Heart Failure Association of the European Society of Cardiology.", "authors": [{"family": "Rosano", "given": "Giuseppe", "initials": "G"}, {"family": "Jankowska", "given": "Ewa A", "initials": "EA"}, {"family": "Ray", "given": "Robin", "initials": "R"}, {"family": "Metra", "given": "Marco", "initials": "M"}, {"family": "Abdelhamid", "given": "Magdy", "initials": "M"}, {"family": "Adamopoulos", "given": "Stamatis", "initials": "S"}, {"family": "Anker", "given": "Stefan D", "initials": "SD"}, {"family": "Bayes-Genis", "given": "Antoni", "initials": "A"}, {"family": "Belenkov", "given": "Yuri", "initials": "Y"}, {"family": "Gal", "given": "Tuvia B", "initials": "TB"}, {"family": "B\u00f6hm", "given": "Michael", "initials": "M"}, {"family": "Chioncel", "given": "Ovidiu", "initials": "O"}, {"family": "Cohen-Solal", "given": "Alain", "initials": "A"}, {"family": "Farmakis", "given": "Dimitrios", "initials": "D"}, {"family": "Filippatos", "given": "Gerasimos", "initials": "G"}, {"family": "Gonz\u00e1lez", "given": "Arantxa", "initials": "A"}, {"family": "Gustafsson", "given": "Finn", "initials": "F"}, {"family": "Hill", "given": "Loreena", "initials": "L"}, {"family": "Jaarsma", "given": "Tiny", "initials": "T"}, {"family": "Jouhra", "given": "Fadi", "initials": "F"}, {"family": "Lainscak", "given": "Mitja", "initials": "M"}, {"family": "Lambrinou", "given": "Ekaterini", "initials": "E"}, {"family": "Lopatin", "given": "Yury", "initials": "Y"}, {"family": "Lund", "given": "Lars H", "initials": "LH"}, {"family": "Milicic", "given": "Davor", "initials": "D"}, {"family": "Moura", "given": "Brenda", "initials": "B"}, {"family": "Mullens", "given": "Wilfried", "initials": "W"}, {"family": "Piepoli", "given": "Massimo F", "initials": "MF"}, {"family": "Ponikowski", "given": "Piotr", "initials": "P"}, {"family": "Rakisheva", "given": "Amina", "initials": "A"}, {"family": "Ristic", "given": "Arsen", "initials": "A"}, {"family": "Savarese", "given": "Gianluigi", "initials": "G"}, {"family": "Seferovic", "given": "Petar", "initials": "P"}, {"family": "Senni", "given": "Michele", "initials": "M"}, {"family": "Thum", "given": "Thomas", "initials": "T"}, {"family": "Tocchetti", "given": "Carlo G", "initials": "CG"}, {"family": "Van Linthout", "given": "Sophie", "initials": "S"}, {"family": "Volterrani", "given": "Maurizio", "initials": "M"}, {"family": "Coats", "given": "Andrew J S", "initials": "AJS"}], "type": "journal article", "published": "2021-10-06", "journal": {"title": "Eur J Heart Fail", "issn": "1879-0844", "issn-l": "1388-9842"}, "abstract": "Patients with heart failure (HF) who contract SARS-CoV-2 infection are at a higher risk of cardiovascular and non-cardiovascular morbidity and mortality. Regardless of therapeutic attempts in COVID-19, vaccination remains the most promising global approach at present for controlling this disease. There are several concerns and misconceptions regarding the clinical indications, optimal mode of delivery, safety and efficacy of COVID-19 vaccines for patients with HF. This document provides guidance to all healthcare professionals regarding the implementation of a COVID-19 vaccination scheme in patients with HF. COVID-19 vaccination is indicated in all patients with HF, including those who are immunocompromised (e.g. after heart transplantation receiving immunosuppressive therapy) and with frailty syndrome. It is preferable to vaccinate against COVID-19 patients with HF in an optimal clinical state, which would include clinical stability, adequate hydration and nutrition, optimized treatment of HF and other comorbidities (including iron deficiency), but corrective measures should not be allowed to delay vaccination. Patients with HF who have been vaccinated against COVID-19 need to continue precautionary measures, including the use of facemasks, hand hygiene and social distancing. Knowledge on strategies preventing SARS-CoV-2 infection (including the COVID-19 vaccination) should be included in the comprehensive educational programmes delivered to patients with HF. This article is protected by copyright. All rights reserved.", "doi": "10.1002/ejhf.2356", "pmid": "34612556", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:28:10.061Z", "modified": "2021-10-10T15:28:10.071Z"}, {"entity": "publication", "iuid": "56c9f4f3d9104458b6a4725592079790", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56c9f4f3d9104458b6a4725592079790.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56c9f4f3d9104458b6a4725592079790"}}, "title": "Metabolic Perturbation Associated With COVID-19 Disease Severity and SARS-CoV-2 Replication.", "authors": [{"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Nordqvist", "given": "Hampus", "initials": "H"}, {"family": "Ambikan", "given": "Anoop T", "initials": "AT", "orcid": "0000-0002-5221-9085", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b14201e4cc547bd8b47d8c27bd0189d.json"}}, {"family": "Gupta", "given": "Soham", "initials": "S", "orcid": "0000-0003-1136-3010", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e94ad93c8263474ab2a9f46a82e763ad.json"}}, {"family": "Sperk", "given": "Maike", "initials": "M"}, {"family": "Svensson-Akusj\u00e4rvi", "given": "Sara", "initials": "S", "orcid": "0000-0002-1086-5409", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20ca29a0c3544bacbf5c44e60263f0a3.json"}}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "Benfeitas", "given": "Rui", "initials": "R", "orcid": "0000-0001-7972-0083", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88e286a997e8409193c9c8713d324f81.json"}}, {"family": "Saccon", "given": "Elisa", "initials": "E", "orcid": "0000-0003-3283-4432", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28cbb3510cbc4bf5b4db2bee1689467f.json"}}, {"family": "Ponnan", "given": "Sivasankaran Munusamy", "initials": "SM"}, {"family": "Rodriguez", "given": "Jimmy Esneider", "initials": "JE", "orcid": "0000-0002-6735-3332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/687f0a9fa4a94f1cb2d7c7bcf504a48d.json"}}, {"family": "Nikouyan", "given": "Negin", "initials": "N"}, {"family": "Odeh", "given": "Amani", "initials": "A"}, {"family": "Ahl\u00e9n", "given": "Gustaf", "initials": "G"}, {"family": "Asghar", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-9017-2206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0e95806bb4a4dca8363a6d9618c678d.json"}}, {"family": "S\u00e4llberg", "given": "Matti", "initials": "M"}, {"family": "Vesterbacka", "given": "Jan", "initials": "J"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "V\u00e9gv\u00e1ri", "given": "\u00c1kos", "initials": "\u00c1", "orcid": "0000-0002-1287-0906", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d68085d6c3b541afbca67e17b2c42cd7.json"}}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Treutiger", "given": "Carl Johan", "initials": "CJ"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "journal article", "published": "2021-10-05", "journal": {"title": "Mol Cell Proteomics", "issn": "1535-9484", "issn-l": null, "volume": "20", "issue": null, "pages": "100159"}, "abstract": "Viruses hijack host metabolic pathways for their replicative advantage. In this study, using patient-derived multiomics data and in vitro infection assays, we aimed to understand the role of key metabolic pathways that can regulate severe acute respiratory syndrome coronavirus-2 reproduction and their association with disease severity. We used multiomics platforms (targeted and untargeted proteomics and untargeted metabolomics) on patient samples and cell-line models along with immune phenotyping of metabolite transporters in patient blood cells to understand viral-induced metabolic modulations. We also modulated key metabolic pathways that were identified using multiomics data to regulate the viral reproduction in vitro. Coronavirus disease 2019 disease severity was characterized by increased plasma glucose and mannose levels. Immune phenotyping identified altered expression patterns of carbohydrate transporter, glucose transporter 1, in CD8+ T cells, intermediate and nonclassical monocytes, and amino acid transporter, xCT, in classical, intermediate, and nonclassical monocytes. In in vitro lung epithelial cell (Calu-3) infection model, we found that glycolysis and glutaminolysis are essential for virus replication, and blocking these metabolic pathways caused significant reduction in virus production. Taken together, we therefore hypothesized that severe acute respiratory syndrome coronavirus-2 utilizes and rewires pathways governing central carbon metabolism leading to the efflux of toxic metabolites and associated with disease severity. Thus, the host metabolic perturbation could be an attractive strategy to limit the viral replication and disease severity.", "doi": "10.1016/j.mcpro.2021.100159", "pmid": "34619366", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S1535-9476(21)00131-6"}, {"db": "pmc", "key": "PMC8490130"}], "notes": [], "created": "2021-03-08T14:54:26.783Z", "modified": "2022-02-16T07:35:24.059Z"}, {"entity": "publication", "iuid": "3af6dbea939b4957afb69291a136ea31", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3af6dbea939b4957afb69291a136ea31.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3af6dbea939b4957afb69291a136ea31"}}, "title": "High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19.", "authors": [{"family": "Lourda", "given": "Magda", "initials": "M", "orcid": "0000-0003-3155-1123", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09048dd72d384232932b004149b543e4.json"}}, {"family": "Dzidic", "given": "Majda", "initials": "M"}, {"family": "Hertwig", "given": "Laura", "initials": "L", "orcid": "0000-0002-1170-0948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbc76f6fbe8b4fcebfa928374618b304.json"}}, {"family": "Bergsten", "given": "Helena", "initials": "H"}, {"family": "Palma Medina", "given": "Laura M", "initials": "LM"}, {"family": "Sinha", "given": "Indranil", "initials": "I", "orcid": "0000-0002-2513-5927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/261f9a5460a64c1fb21331b6619b068d.json"}}, {"family": "Kvedaraite", "given": "Egle", "initials": "E"}, {"family": "Chen", "given": "Puran", "initials": "P", "orcid": "0000-0002-2890-0022", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d90f1cd607240b6bad38c32855b58d2.json"}}, {"family": "Muvva", "given": "Jagadeeswara R", "initials": "JR"}, {"family": "Gorin", "given": "Jean-Baptiste", "initials": "JB"}, {"family": "Cornillet", "given": "Martin", "initials": "M", "orcid": "0000-0001-7981-0927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20d0c2fd2be843668806a91d2d83104b.json"}}, {"family": "Emg\u00e5rd", "given": "Johanna", "initials": "J"}, {"family": "Moll", "given": "Kirsten", "initials": "K"}, {"family": "Garc\u00eda", "given": "Marina", "initials": "M", "orcid": "0000-0002-9130-3933", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5b109d7a54e4c05a48e0f21c4432be6.json"}}, {"family": "Maleki", "given": "Kimia T", "initials": "KT", "orcid": "0000-0001-5382-5477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c0313be527f49c0b41a37115a68408d.json"}}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Flodstr\u00f6m-Tullberg", "given": "Malin", "initials": "M"}, {"family": "Brighenti", "given": "Susanna", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J"}, {"family": "Malmberg", "given": "Karl-Johan", "initials": "KJ"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK", "orcid": "0000-0002-6275-0750", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61225c074353413bb0b19c43b555732a.json"}}, {"family": "Henter", "given": "Jan-Inge", "initials": "JI", "orcid": "0000-0002-0629-2126", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a88b3feb9554be1804f4836f2dc36de.json"}}, {"family": "Folkesson", "given": "Elin", "initials": "E"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S", "orcid": "0000-0002-2446-4323", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/363ff940d9c64575a11bd45372927b2c.json"}}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Aleman", "given": "Soo", "initials": "S", "orcid": "0000-0003-0461-4870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b0edb2db8d840989936f67047ce91de.json"}}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-8801-3169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37509c3832244b019b91a1fe2cbe183e.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG", "orcid": "0000-0003-0908-7387", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48a59f01e46c41038301a586178e8e2a.json"}}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4691d38f3268433696d7c65ea235a12b.json"}}, {"family": "Svensson", "given": "Mattias", "initials": "M", "orcid": "0000-0003-1695-7934", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7ae76a597164d02b4fcfadfe53c48a3.json"}}, {"family": "Ponzetta", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3224-802X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8d6bca49dc24e558ca8f0b3637d7702.json"}}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A", "orcid": "0000-0001-9372-1795", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb1e61066d6451c920200f83e99cb9e.json"}}, {"family": "Chambers", "given": "Benedict J", "initials": "BJ", "orcid": "0000-0003-0437-8441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6089d99ec42d475f8f57c8d8cc1ff1de.json"}}, {"family": "Karolinska KI/K COVID-19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-10-05", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "issn-l": "0027-8424", "volume": "118", "issue": "40", "pages": null}, "abstract": "Since the outset of the COVID-19 pandemic, increasing evidence suggests that the innate immune responses play an important role in the disease development. A dysregulated inflammatory state has been proposed as a key driver of clinical complications in COVID-19, with a potential detrimental role of granulocytes. However, a comprehensive phenotypic description of circulating granulocytes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients is lacking. In this study, we used high-dimensional flow cytometry for granulocyte immunophenotyping in peripheral blood collected from COVID-19 patients during acute and convalescent phases. Severe COVID-19 was associated with increased levels of both mature and immature neutrophils, and decreased counts of eosinophils and basophils. Distinct immunotypes were evident in COVID-19 patients, with altered expression of several receptors involved in activation, adhesion, and migration of granulocytes (e.g., CD62L, CD11a/b, CD69, CD63, CXCR4). Paired sampling revealed recovery and phenotypic restoration of the granulocytic signature in the convalescent phase. The identified granulocyte immunotypes correlated with distinct sets of soluble inflammatory markers, supporting pathophysiologic relevance. Furthermore, clinical features, including multiorgan dysfunction and respiratory function, could be predicted using combined laboratory measurements and immunophenotyping. This study provides a comprehensive granulocyte characterization in COVID-19 and reveals specific immunotypes with potential predictive value for key clinical features associated with COVID-19.", "doi": "10.1073/pnas.2109123118", "pmid": "34548411", "labels": {"Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2109123118"}], "notes": [], "created": "2021-02-02T11:37:31.818Z", "modified": "2021-09-23T05:17:12.682Z"}, {"entity": "publication", "iuid": "f4a45618e0384dfab5459663691b324b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f4a45618e0384dfab5459663691b324b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f4a45618e0384dfab5459663691b324b"}}, "title": "Establishing a COVID-19 pandemic severity assessment surveillance system in Ireland.", "authors": [{"family": "Domegan", "given": "Lisa", "initials": "L", "orcid": "0000-0002-7483-6703", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b12d1831028479eb6303b6c8d348ccb.json"}}, {"family": "Garvey", "given": "Patricia", "initials": "P"}, {"family": "McEnery", "given": "Maeve", "initials": "M"}, {"family": "Fiegenbaum", "given": "Rachel", "initials": "R"}, {"family": "Brabazon", "given": "Elaine", "initials": "E"}, {"family": "Quintyne", "given": "Keith Ian", "initials": "KI"}, {"family": "O'Connor", "given": "Lois", "initials": "L"}, {"family": "Cuddihy", "given": "John", "initials": "J"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}], "type": "journal article", "published": "2021-10-05", "journal": {"title": "Influenza Other Respir Viruses", "issn": "1750-2659", "issn-l": null}, "abstract": "We developed a COVID-19 pandemic severity assessment (PSA) monitoring system in Ireland, in order to inform and improve public health preparedness, response and recovery. The system based on the World Health Organization (WHO) Pandemic Influenza Severity Assessment (PISA) project included a panel of surveillance parameters for the following indicators: transmissibility, impact and disease severity. Age-specific thresholds were established for each parameter and data visualised using heat maps. The findings from the first pandemic wave in Ireland have shown that the WHO PISA system can be adapted for COVID-19, providing a standardised tool for early warning and monitoring pandemic severity.", "doi": "10.1111/irv.12890", "pmid": "34609049", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:29:42.777Z", "modified": "2021-10-10T15:29:42.827Z"}, {"entity": "publication", "iuid": "539c23ed279c4d11a59b88fe8519bbc5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/539c23ed279c4d11a59b88fe8519bbc5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/539c23ed279c4d11a59b88fe8519bbc5"}}, "title": "Associations of Disease-Modifying Therapies With COVID-19 Severity in Multiple Sclerosis.", "authors": [{"family": "Simpson-Yap", "given": "Steve", "initials": "S", "orcid": "0000-0001-6521-3056", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/845cbea3a2f64b9f880a43d6cc8cdb09.json"}}, {"family": "De Brouwer", "given": "Edward", "initials": "E"}, {"family": "Kalincik", "given": "Tomas", "initials": "T", "orcid": "0000-0003-3778-1376", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d57266f045d648a8b749b6496f4b2fc5.json"}}, {"family": "Rijke", "given": "Nick", "initials": "N"}, {"family": "Hillert", "given": "Jan A", "initials": "JA"}, {"family": "Walton", "given": "Clare", "initials": "C"}, {"family": "Edan", "given": "Gilles", "initials": "G"}, {"family": "Moreau", "given": "Yves", "initials": "Y"}, {"family": "Spelman", "given": "Tim", "initials": "T"}, {"family": "Geys", "given": "Lotte", "initials": "L"}, {"family": "Parciak", "given": "Tina", "initials": "T", "orcid": "0000-0002-1989-3641", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19f442e54aa847db9aeb8df80b28bc2f.json"}}, {"family": "Gautrais", "given": "Clement", "initials": "C"}, {"family": "Lazovski", "given": "Nikola", "initials": "N"}, {"family": "Pirmani", "given": "Ashkan", "initials": "A", "orcid": "0000-0003-4549-1002", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d72bbbd407ef4f5387e6653e68e127fc.json"}}, {"family": "Ardeshirdavanai", "given": "Amin", "initials": "A", "orcid": "0000-0002-7226-7324", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f886fb5d880b48828dd8f72c57deb510.json"}}, {"family": "Forsberg", "given": "Lars", "initials": "L", "orcid": "0000-0002-3536-1813", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b57c570dfe5e489c98831771524f0267.json"}}, {"family": "Glaser", "given": "Anna", "initials": "A"}, {"family": "McBurney", "given": "Robert", "initials": "R", "orcid": "0000-0003-1747-1004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2f7c9449433431198c390f39cf1d930.json"}}, {"family": "Schmidt", "given": "Hollie", "initials": "H"}, {"family": "Bergmann", "given": "Arnfin B", "initials": "AB"}, {"family": "Braune", "given": "Stefan", "initials": "S"}, {"family": "Stahmann", "given": "Alexander", "initials": "A", "orcid": "0000-0001-5308-105X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/da733ad3878f45738e211c7317b3edda.json"}}, {"family": "Middleton", "given": "Rodden", "initials": "R", "orcid": "0000-0002-2130-4420", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7adf9663f3ea4db7b2bfc70b724ad309.json"}}, {"family": "Salter", "given": "Amber", "initials": "A", "orcid": "0000-0002-1088-110X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e108ab0c847c4d5b8e66af7cfb6619ec.json"}}, {"family": "Fox", "given": "Robert J", "initials": "RJ", "orcid": "0000-0002-4263-3717", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c20b76857014771847ad29d94572445.json"}}, {"family": "van der Walt", "given": "Anneke", "initials": "A", "orcid": "0000-0002-4278-7003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4636e8ba06d94593929e1c30619cc500.json"}}, {"family": "Butzkueven", "given": "Helmut", "initials": "H"}, {"family": "Alroughani", "given": "Raed", "initials": "R"}, {"family": "Ozakbas", "given": "Serkan", "initials": "S"}, {"family": "Rojas", "given": "Juan I", "initials": "JI"}, {"family": "van der Mei", "given": "Ingrid", "initials": "I"}, {"family": "Nag", "given": "Nupur", "initials": "N", "orcid": "0000-0002-0271-0781", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e143288e60634d7aae97a2db6c73350a.json"}}, {"family": "Ivanov", "given": "Rumen", "initials": "R"}, {"family": "Sciascia do Olival", "given": "Guilherme", "initials": "G", "orcid": "0000-0002-2717-7522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67a109d6755d46528b376eab394b3f44.json"}}, {"family": "Dias", "given": "Alice Estavo", "initials": "AE"}, {"family": "Magyari", "given": "Melinda", "initials": "M", "orcid": "0000-0002-0972-5222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4138641b9754548a434173a3f677e4a.json"}}, {"family": "Brum", "given": "Doralina", "initials": "D"}, {"family": "Mendes", "given": "Maria Fernanda", "initials": "MF"}, {"family": "Alonso", "given": "Ricardo N", "initials": "RN"}, {"family": "Nicholas", "given": "Richard S", "initials": "RS"}, {"family": "Bauer", "given": "Johana", "initials": "J"}, {"family": "Chertcoff", "given": "An\u00edbal Sebasti\u00e1n", "initials": "AS"}, {"family": "Zabalza", "given": "Anna", "initials": "A", "orcid": "0000-0003-3860-5251", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f24a8041d09442178e1f1f007f20c3e5.json"}}, {"family": "Arrambide", "given": "Georgina", "initials": "G", "orcid": "0000-0002-2657-5510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45c169a840fe487e8ed7b286e6c3708f.json"}}, {"family": "Fidao", "given": "Alex", "initials": "A"}, {"family": "Comi", "given": "Giancarlo", "initials": "G"}, {"family": "Peeters", "given": "Liesbet", "initials": "L"}], "type": "journal article", "published": "2021-10-05", "journal": {"title": "Neurology", "issn": "1526-632X", "issn-l": "0028-3878"}, "abstract": "People with multiple sclerosis (MS) are a vulnerable group for severe COVID- 19, particularly those taking immunosuppressive disease-modifying therapies (DMTs). We examined the characteristics of COVID-19 severity in an international sample of people with MS.\n\nData from 12 data-sources in 28 countries were aggregated (sources could include patients from 1-12 countries). Demographic (age, sex), clinical (MS-phenotype, disability), and DMT (untreated, alemtuzumab, cladribine, dimethyl-fumarate, glatiramer acetate, interferon, natalizumab, ocrelizumab, rituximab, siponimod, other DMTs) covariates were queried, alongside COVID-19 severity outcomes, hospitalisation, ICU admission, requiring artificial ventilation, and death. Characteristics of outcomes were assessed in patients with suspected/confirmed COVID-19 using multilevel mixed-effects logistic regression, adjusted for age, sex, MS-phenotype, and EDSS.\n\n657(28.1%) with suspected and 1,683(61.9%) with confirmed COVID-19 were analysed. Among suspected+confirmed and confirmed-only COVID-19, 20.9% and 26.9% were hospitalised, 5.4% and 7.2% were admitted to ICU, 4.1% and 5.4% required artificial ventilation, and 3.2% and 3.9% died. Older age, progressive MS-phenotype, and higher disability were associated with worse COVID-19 outcomes. Compared to dimethyl-fumarate, ocrelizumab and rituximab were associated with hospitalisation (aOR=1.56,95%CI=1.01- 2.41; aOR=2.43,95%CI=1.48-4.02) and ICU admission (aOR=2.30,95%CI=0.98-5.39;aOR=3.93,95%CI=1.56-9.89), though only rituximab was associated with higher risk of artificial ventilation (aOR=4.00,95%CI=1.54-10.39). Compared to pooled other DMTs, ocrelizumab and rituximab were associated with hospitalisation (aOR=1.75,95%CI=1.29- 2.38; aOR=2.76,95%CI=1.87-4.07) and ICU admission (aOR=2.55,95%CI=1.49-4.36;aOR=4.32,95%CI=2.27-8.23) but only rituximab with artificial ventilation (aOR=6.15,95%CI=3.09-12.27). Compared to natalizumab, ocrelizumab and rituximab wereassociated with hospitalisation (aOR=1.86,95%CI=1.13-3.07; aOR=2.88,95%CI=1.68-4.92) and ICU admission (aOR=2.13,95%CI=0.85-5.35; aOR=3.23,95%CI=1.17-8.91), but only rituximab with ventilation (aOR=5.52,95%CI=1.71-17.84). Importantly, associations persisted on restriction to confirmed COVID-19 cases. No associations were observed between DMTs and death. Stratification by age, MS-phenotype, and EDSS found no indications that DMT associations with COVID-19 severity reflected differential DMT allocation by underlying COVID-19 severity.\n\nUsing the largest cohort of people with MS and COVID-19 available, we demonstrated consistent associations of rituximab with increased risk of hospitalisation, ICU admission, and requiring artificial ventilation, and ocrelizumab with hospitalisation and ICU admission. Despite the study's cross-sectional design, the internal and external consistency of these results with prior studies suggests rituximab/ocrelizumab use may be a risk factor for more severe COVID-19.", "doi": "10.1212/WNL.0000000000012753", "pmid": "34610987", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "WNL.0000000000012753"}], "notes": [], "created": "2021-10-10T15:28:34.500Z", "modified": "2021-10-10T15:28:34.892Z"}, {"entity": "publication", "iuid": "0d721ff011d1404d8b5d41856ba512d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d721ff011d1404d8b5d41856ba512d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d721ff011d1404d8b5d41856ba512d4"}}, "title": "Adverse events of special interest for COVID-19 vaccines - background incidences vary by sex, age and time period and are affected by the pandemic", "authors": [{"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW"}, {"family": "Hammar", "given": "Niklas", "initials": "N"}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Kirui", "given": "Brian K", "initials": "BK"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "posted-content", "published": "2021-10-05", "journal": {"title": "MedRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.10.04.21263507", "pmid": null, "labels": {"Category: Health": null, "Research Area: Vaccine": null, "Funder: KAW/SciLifeLab": null, "Type: Preprint": null, "Topics: Register-based research": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-10-21T05:51:25.592Z", "modified": "2022-02-06T17:44:13.656Z"}, {"entity": "publication", "iuid": "ee65ea75cad04e3e90c520ef967bb5f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee65ea75cad04e3e90c520ef967bb5f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee65ea75cad04e3e90c520ef967bb5f8"}}, "title": "Assessing relative COVID-19 mortality during the second wave: a prospective Swiss population-based study.", "authors": [{"family": "Siegfried", "given": "Sandra", "initials": "S", "orcid": "0000-0002-7312-1001", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5e6f621879e43d589a82fae0ae5d7d6.json"}}, {"family": "Bopp", "given": "Matthias", "initials": "M"}, {"family": "G\u00fcnthard", "given": "Huldrych", "initials": "H"}, {"family": "Keiser", "given": "Olivia", "initials": "O"}, {"family": "Weibull", "given": "Caroline E", "initials": "CE"}, {"family": "Crowther", "given": "Michael", "initials": "M"}, {"family": "Hothorn", "given": "Torsten", "initials": "T", "orcid": "0000-0001-8301-0471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a9fe39a0c764477ab308928f6e8228b.json"}}], "type": "journal article", "published": "2021-10-04", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "10", "pages": "e051164", "issn-l": "2044-6055"}, "abstract": "During the first COVID-19 wave in Switzerland, relative mortality was at least eight times higher compared with the uninfected general population. We aimed to assess sex-specific and age-specific relative mortality associated with a SARS-CoV-2 diagnosis during the second wave.\n\nProspective population-based study.\n\nIndividuals testing positive for SARS-CoV-2 after the start of the second wave on 1 October 2020 were followed up until death or administrative censoring on 31 December 2020.\n\n5 179 740 inhabitants of Switzerland in fall 2018 aged 35-95 years (without COVID-19) and 257 288 persons tested positive for SARS-CoV-2 by PCR or antigen testing during the second wave.\n\nThe planned outcome measure was time to death from any cause, measured from the date of a SARS-CoV-2 diagnosis or 1 October in the general population. Information on confirmed SARS-CoV-2 diagnoses and deaths was matched by calendar time with the all-cause mortality of the general Swiss population of 2018. Proportional hazards models were used to estimate sex-specific and age-specific mortality rates and probabilities of death within 60 days.\n\nThe risk of death for individuals tested positive for SARS-CoV-2 in the second wave in Switzerland increased at least sixfold compared with the general population. HRs, reflecting the risk attributable to a SARS-CoV-2 infection, were higher for men (1.40, 95% CI 1.29 to 1.52) and increased for each additional year of age (1.01, 95% CI 1.01 to 1.02). COVID-19 mortality was reduced by at least 20% compared with the first wave in spring 2020.\n\nGeneral mortality patterns, increased for men and older persons, were similar in spring and in fall. Absolute and relative COVID-19 mortality was smaller in fall.\n\nThe protocol for this study was registered on 3 December 2020 at https://osf.io/gbd6r.", "doi": "10.1136/bmjopen-2021-051164", "pmid": "34607868", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-051164"}, {"db": "pmc", "key": "PMC8491006"}], "notes": [], "created": "2021-10-10T15:30:25.734Z", "modified": "2021-10-10T15:32:26.473Z"}, {"entity": "publication", "iuid": "04ce8b77317e40369326ca286363bd5b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/04ce8b77317e40369326ca286363bd5b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/04ce8b77317e40369326ca286363bd5b"}}, "title": "ATG and Post-transplant Cyclophosphamide predisposes to inferior outcome when using cryopreserved stem cell grafts.", "authors": [{"family": "Novitzky-Basso", "given": "Igor", "initials": "I", "orcid": "0000-0003-3748-3117", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6f8f01041fa4649b5f3b11d44bae033.json"}}, {"family": "Remberger", "given": "Mats", "initials": "M", "orcid": "0000-0003-0520-4312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/133deb67baba4c55ac292259d1a4500e.json"}}, {"family": "Chen", "given": "Carol", "initials": "C"}, {"family": "Pasi\u0107", "given": "Ivan", "initials": "I", "orcid": "0000-0001-7595-0113", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6f675a4dd4842c496475438e9ce40f5.json"}}, {"family": "Lam", "given": "Wilson", "initials": "W"}, {"family": "Law", "given": "Arjun", "initials": "A"}, {"family": "Gerbitz", "given": "Armin", "initials": "A"}, {"family": "Viswabandya", "given": "Auro", "initials": "A"}, {"family": "Lipton", "given": "Jeffrey H", "initials": "JH", "orcid": "0000-0001-7391-7168", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6366fdc4b85a4d4e99676639ac8aa491.json"}}, {"family": "Kim", "given": "Dennis D", "initials": "DD"}, {"family": "Kumar", "given": "Rajat", "initials": "R"}, {"family": "Mattsson", "given": "Jonas", "initials": "J"}, {"family": "Michelis", "given": "Fotios V", "initials": "FV", "orcid": "0000-0003-2956-0848", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/85171f94f0cb4bb598fa1d6dba89aa6c.json"}}], "type": "journal article", "published": "2021-10-04", "journal": {"title": "Eur J Haematol", "issn": "1600-0609", "issn-l": null}, "abstract": "During 2020, the concurrent novel COVID-19 pandemic lead to widespread cryopreservation of allogeneic HCT grafts based on NMDP and EBMT recommendations, in order to secure grafts before the start of conditioning chemotherapy. We sought to examine the impact of this change in practice on patient outcomes. We analyzed the outcomes of 483 patients who received HSCT between August 2017 and August 2020, at Princess Margaret Cancer Centre, Canada, in the retrospective study, comparing the outcomes between those who received cryopreserved or fresh peripheral blood stem cell grafts. Overall compared to those who received fresh grafts (n=348), patients who received cryopreserved grafts (n=135) had reduced survival and GRFS, reduced incidence of chronic GvHD, delay in neutrophil engraftment and higher graft failure, with no significant difference in relapse incidence or acute GvHD. However, recipients of cryopreserved matched related donor HSCT showed significantly worse OS, NRM, GRFS compared to fresh grafts. Multivariable analysis of the entire cohort showed significant impact of cryopreservation on OS, relapse, cGvHD, graft failure and GRFS. We conclude that cryopreservation was associated with inferior outcomes post-HSCT, possibly due to the combination of ATG and post-transplant cyclophosphamide impacting differential tolerance to cryopreservation on components of the stem cell graft; further studies are warranted to elucidate mechanisms for this observation.", "doi": "10.1111/ejh.13714", "pmid": "34606661", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:55:56.022Z", "modified": "2021-10-11T17:55:56.247Z"}, {"entity": "publication", "iuid": "fa05a20338ca42da8ff871da200388c4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa05a20338ca42da8ff871da200388c4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa05a20338ca42da8ff871da200388c4"}}, "title": "Pooled testing for SARS-CoV-2, options for efficiency at scale.", "authors": [{"family": "Reilly", "given": "Marie", "initials": "M"}, {"family": "Chohan", "given": "Bhavna", "initials": "B"}], "type": "journal article", "published": "2021-10-01", "journal": {"title": "Bull World Health Organ", "issn": "1564-0604", "volume": "99", "issue": "10", "pages": "708-714", "issn-l": null}, "abstract": "Widescale testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is recognized as a key element of surveillance and outbreak control in the coronavirus disease 2019 (COVID-19) pandemic. The practical challenges, however, have often led to testing only symptomatic individuals and their close contacts. As many countries plan for a cautious relaxation of social restrictions, more effective approaches for widescale testing are increasingly important. Early in the COVID-19 pandemic, laboratories in several countries demonstrated the feasibility of detecting SARS-CoV-2 infection by pooled testing, which combines the specimens from several individuals. Since no further testing is needed for individuals in a negative pool, there is potential for greater efficiency of testing. Despite validations of the accuracy of the results and the efficiency in testing specific groups, the benefits of pooling are less acknowledged as a population surveillance strategy that can detect new disease outbreaks without posing restrictions on entire societies. Pooling specimens from natural clusters, such as school classes, sports teams, workplace colleagues and other social networks, would enable timely and cost-effective widescale testing for SARS-CoV-2. The initial result would be readily translatable into action in terms of quarantine and isolation policies. Clusters of uninfected individuals would be quickly identified and immediate local lockdown of positive clusters would be the appropriate and sufficient action while retesting those individuals. By adapting to the social networks of a population, pooled testing offers a cost-efficient surveillance system that is synchronized with quarantine policies that are rational, risk-based and equitable.", "doi": "10.2471/BLT.20.283093", "pmid": "34621088", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Other": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "BLT.20.283093"}, {"db": "pmc", "key": "PMC8477423"}], "notes": [], "created": "2021-10-10T15:09:06.074Z", "modified": "2021-10-10T15:09:06.098Z"}, {"entity": "publication", "iuid": "c702b47064944448a7ec4b0082312820", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c702b47064944448a7ec4b0082312820.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c702b47064944448a7ec4b0082312820"}}, "title": "Physical Activity and Perceived Health in People With Parkinson Disease During the First Wave of Covid-19 Pandemic: A Cross-sectional Study From Sweden.", "authors": [{"family": "Leavy", "given": "Breiffni", "initials": "B"}, {"family": "Hagstr\u00f6mer", "given": "Maria", "initials": "M"}, {"family": "Conradsson", "given": "David Moulaee", "initials": "DM"}, {"family": "Franz\u00e9n", "given": "Erika", "initials": "E"}], "type": "journal article", "published": "2021-10-01", "journal": {"title": "J Neurol Phys Ther", "issn": "1557-0584", "issn-l": null, "volume": "45", "issue": "4", "pages": "266-272"}, "abstract": "People with Parkinson disease (PD) are known to be at risk of physical inactivity and may therefore be especially vulnerable to negative health outcomes during the COVID-19 pandemic due to social distancing recommendations.\r\n\r\nTo investigate sensor-derived physical activity and perceived health of people with PD during the first wave of the COVID-19 pandemic, as well as the factors associated with these outcomes.\r\n\r\nPhysical activity was measured over 7 days using the Actigraph GT3x accelerometer. Data were collected regarding perceived health status and physical activity habits, as well as rehabilitation attendance during the pandemic. Multiple linear and logistic regression analyses were used to identify factors associated with physical activity and perceived changes in health.\r\n\r\nOf 89 participants, a majority (67%) reported a pandemic-related reduction in exercise habits. Women more commonly reported a reduction in scheduled exercise and cancelled rehabilitation than men. Study participants took on average 5876 \u00b1 3180 steps per day. In the multivariate analysis, female gender, being 70 years of age and older, and greater reported mobility problems were associated with being less physically active. A pandemic-induced deterioration in health was reported by 42% and women were 5 times more likely than men to do so (odds ratio: 5.12, 95% confidence interval, 1.87-15.03; P = 0.002).\r\n\r\nDespite a pandemic-related reduction in reported exercise habits and rehabilitation, the participants in this Swedish sample were relatively physically active. However, women were less active at moderate-vigorous levels and were at greater risk of deterioration in perceived health during this time.Video Abstract available for more insight from the authors (see the Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A359).", "doi": "10.1097/NPT.0000000000000372", "pmid": "34369451", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "01253086-900000000-99717"}, {"db": "ClinicalTrials.gov", "key": "NCT03213873"}], "notes": [], "created": "2021-08-11T14:34:18.812Z", "modified": "2022-02-17T10:23:22.720Z"}, {"entity": "publication", "iuid": "88edfc6421854b69bb11ce43ab061062", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/88edfc6421854b69bb11ce43ab061062.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/88edfc6421854b69bb11ce43ab061062"}}, "title": "Low-quality employment trajectories and risk of common mental disorders, substance use disorders and suicide attempt: a longitudinal study of the Swedish workforce.", "authors": [{"family": "Jonsson", "given": "Johanna", "initials": "J"}, {"family": "Muntaner", "given": "Carles", "initials": "C"}, {"family": "Bodin", "given": "Theo", "initials": "T"}, {"family": "Alderling", "given": "Magnus", "initials": "M"}, {"family": "Rebeka", "given": "Rebeka", "initials": "R"}, {"family": "Burstr\u00f6m", "given": "Bo", "initials": "B"}, {"family": "Davis", "given": "Letitia", "initials": "L"}, {"family": "Gunn", "given": "Virginia", "initials": "V"}, {"family": "Hemmingsson", "given": "Tomas", "initials": "T"}, {"family": "Juli\u00e0", "given": "Mireia", "initials": "M"}, {"family": "Kjellberg", "given": "Katarina", "initials": "K"}, {"family": "Kreshpaj", "given": "Bertina", "initials": "B"}, {"family": "Orellana", "given": "Cecilia", "initials": "C"}, {"family": "Padrosa", "given": "Eva", "initials": "E"}, {"family": "Wegman", "given": "David H", "initials": "DH"}, {"family": "Matilla-Santander", "given": "Nuria", "initials": "N"}], "type": "journal article", "published": "2021-10-01", "journal": {"title": "Scand J Work Environ Health", "issn": "1795-990X", "volume": "47", "issue": "7", "pages": "509-520", "issn-l": null}, "abstract": "High-quality longitudinal evidence exploring the mental health risk associated with low-quality employment trajectories is scarce. We therefore aimed to investigate the risk of being diagnosed with common mental disorders, substance use disorders, or suicide attempt according to low-quality employment trajectories.\n\nA longitudinal register-study based on the working population of Sweden (N=2 743 764). Employment trajectories (2005-2009) characterized by employment quality and pattern (constancy, fluctuation, mobility) were created. Hazard ratios (HR) were estimated using Cox proportional hazards regression models for first incidence (2010-2017) diagnosis of common mental disorders, substance use disorders and suicide attempt as dependent on employment trajectories.\n\nWe identified 21 employment trajectories, 10 of which were low quality (21%). With the exception of constant solo self-employment, there was an increased risk of common mental disorders (HR 1.07-1.62) and substance use disorders (HR 1.05-2.19) for all low-quality trajectories. Constant solo self-employment increased the risk for substance use disorders among women, while it reduced the risk of both disorders for men. Half of the low-quality trajectories were associated with a risk increase of suicide attempt (HR 1.08-1.76).\n\nLow-quality employment trajectories represent risk factors for mental disorders and suicide attempt in Sweden, and there might be differential effects according to sex - especially in terms of self-employment. Policies ensuring and maintaining high-quality employment characteristics over time are imperative. Similar prospective studies are needed, also in other contexts, which cover the effects of the Covid-19 pandemic as well as the mechanisms linking employment trajectories with mental health.", "doi": "10.5271/sjweh.3978", "pmid": "34397098", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "3978"}], "notes": [], "created": "2021-08-17T06:41:56.740Z", "modified": "2021-11-18T13:35:17.405Z"}, {"entity": "publication", "iuid": "4f98608ce2d04e9c870261c3e8afcbb2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4f98608ce2d04e9c870261c3e8afcbb2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4f98608ce2d04e9c870261c3e8afcbb2"}}, "title": "Association Between Tumor Necrosis Factor Inhibitors and the Risk of Hospitalization or Death Among Patients With Immune-Mediated Inflammatory Disease and COVID-19.", "authors": [{"family": "Izadi", "given": "Zara", "initials": "Z"}, {"family": "Brenner", "given": "Erica J", "initials": "EJ"}, {"family": "Mahil", "given": "Satveer K", "initials": "SK"}, {"family": "Dand", "given": "Nick", "initials": "N"}, {"family": "Yiu", "given": "Zenas Z N", "initials": "ZZN"}, {"family": "Yates", "given": "Mark", "initials": "M"}, {"family": "Ungaro", "given": "Ryan C", "initials": "RC"}, {"family": "Zhang", "given": "Xian", "initials": "X"}, {"family": "Agrawal", "given": "Manasi", "initials": "M"}, {"family": "Colombel", "given": "Jean-Frederic", "initials": "JF"}, {"family": "Gianfrancesco", "given": "Milena A", "initials": "MA"}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL"}, {"family": "Strangfeld", "given": "Anja", "initials": "A"}, {"family": "Carmona", "given": "Loreto", "initials": "L"}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S"}, {"family": "Klingberg", "given": "Eva", "initials": "E"}, {"family": "Cuomo", "given": "Giovanna", "initials": "G"}, {"family": "Caprioli", "given": "Marta", "initials": "M"}, {"family": "Cruz-Machado", "given": "Ana Rita", "initials": "AR"}, {"family": "Mazeda Pereira", "given": "Ana Carolina", "initials": "AC"}, {"family": "Hasseli", "given": "Rebecca", "initials": "R"}, {"family": "Pfeil", "given": "Alexander", "initials": "A"}, {"family": "Lorenz", "given": "Hanns-Martin", "initials": "HM"}, {"family": "Hoyer", "given": "Bimba Franziska", "initials": "BF"}, {"family": "Trupin", "given": "Laura", "initials": "L"}, {"family": "Rush", "given": "Stephanie", "initials": "S"}, {"family": "Katz", "given": "Patricia", "initials": "P"}, {"family": "Schmajuk", "given": "Gabriela", "initials": "G"}, {"family": "Jacobsohn", "given": "Lindsay", "initials": "L"}, {"family": "Seet", "given": "Andrea M", "initials": "AM"}, {"family": "Al Emadi", "given": "Samar", "initials": "S"}, {"family": "Wise", "given": "Leanna", "initials": "L"}, {"family": "Gilbert", "given": "Emily L", "initials": "EL"}, {"family": "Duarte-Garc\u00eda", "given": "Al\u00ed", "initials": "A"}, {"family": "Valenzuela-Almada", "given": "Maria O", "initials": "MO"}, {"family": "Isnardi", "given": "Carolina A", "initials": "CA"}, {"family": "Quintana", "given": "Rosana", "initials": "R"}, {"family": "Soriano", "given": "Enrique R", "initials": "ER"}, {"family": "Hsu", "given": "Tiffany Y-T", "initials": "TY"}, {"family": "D'Silva", "given": "Kristin M", "initials": "KM"}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA"}, {"family": "Patel", "given": "Naomi J", "initials": "NJ"}, {"family": "Xavier", "given": "Ricardo Machado", "initials": "RM"}, {"family": "Marques", "given": "Claudia Diniz Lopes", "initials": "CDL"}, {"family": "Kakehasi", "given": "Adriana Maria", "initials": "AM"}, {"family": "Flipo", "given": "Ren\u00e9-Marc", "initials": "RM"}, {"family": "Claudepierre", "given": "Pascal", "initials": "P"}, {"family": "Cantagrel", "given": "Alain", "initials": "A"}, {"family": "Goupille", "given": "Philippe", "initials": "P"}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Costello", "given": "Wendy", "initials": "W"}, {"family": "Grainger", "given": "Rebecca", "initials": "R"}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS"}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Sufka", "given": "Paul", "initials": "P"}, {"family": "Robinson", "given": "Philip C", "initials": "PC"}, {"family": "Machado", "given": "Pedro M", "initials": "PM"}, {"family": "Griffiths", "given": "Christopher E M", "initials": "CEM"}, {"family": "Barker", "given": "Jonathan N", "initials": "JN"}, {"family": "Smith", "given": "Catherine H", "initials": "CH"}, {"family": "Yazdany", "given": "Jinoos", "initials": "J"}, {"family": "Kappelman", "given": "Michael D", "initials": "MD"}, {"family": "Psoriasis Patient Registry for Outcomes, Therapy and Epidemiology of COVID-19 Infection (PsoProtect); the Secure Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease (SECURE-IBD); and the COVID-19 Global Rheumatology Allianc", "given": "", "initials": ""}, {"family": "Psoriasis Patient Registry for Outcomes, Therapy and Epidemiology of COVID-19 Infection (PsoProtect); the Secure Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease (SECURE-IBD); and the COVID-19 Global Rheumatology Alliance (GRA)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-10-01", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "volume": "4", "issue": "10", "pages": "e2129639", "issn-l": null}, "abstract": "Although tumor necrosis factor (TNF) inhibitors are widely prescribed globally because of their ability to ameliorate shared immune pathways across immune-mediated inflammatory diseases (IMIDs), the impact of COVID-19 among individuals with IMIDs who are receiving TNF inhibitors remains insufficiently understood.\n\nTo examine the association between the receipt of TNF inhibitor monotherapy and the risk of COVID-19-associated hospitalization or death compared with other commonly prescribed immunomodulatory treatment regimens among adult patients with IMIDs.\n\nThis cohort study was a pooled analysis of data from 3 international COVID-19 registries comprising individuals with rheumatic diseases, inflammatory bowel disease, and psoriasis from March 12, 2020, to February 1, 2021. Clinicians directly reported COVID-19 outcomes as well as demographic and clinical characteristics of individuals with IMIDs and confirmed or suspected COVID-19 using online data entry portals. Adults (age \u226518 years) with a diagnosis of inflammatory arthritis, inflammatory bowel disease, or psoriasis were included.\n\nTreatment exposure categories included TNF inhibitor monotherapy (reference treatment), TNF inhibitors in combination with methotrexate therapy, TNF inhibitors in combination with azathioprine/6-mercaptopurine therapy, methotrexate monotherapy, azathioprine/6-mercaptopurine monotherapy, and Janus kinase (Jak) inhibitor monotherapy.\n\nThe main outcome was COVID-19-associated hospitalization or death. Registry-level analyses and a pooled analysis of data across the 3 registries were conducted using multilevel multivariable logistic regression models, adjusting for demographic and clinical characteristics and accounting for country, calendar month, and registry-level correlations.\n\nA total of 6077 patients from 74 countries were included in the analyses; of those, 3215 individuals (52.9%) were from Europe, 3563 individuals (58.6%) were female, and the mean (SD) age was 48.8 (16.5) years. The most common IMID diagnoses were rheumatoid arthritis (2146 patients [35.3%]) and Crohn disease (1537 patients [25.3%]). A total of 1297 patients (21.3%) were hospitalized, and 189 patients (3.1%) died. In the pooled analysis, compared with patients who received TNF inhibitor monotherapy, higher odds of hospitalization or death were observed among those who received a TNF inhibitor in combination with azathioprine/6-mercaptopurine therapy (odds ratio [OR], 1.74; 95% CI, 1.17-2.58; P = .006), azathioprine/6-mercaptopurine monotherapy (OR, 1.84; 95% CI, 1.30-2.61; P = .001), methotrexate monotherapy (OR, 2.00; 95% CI, 1.57-2.56; P < .001), and Jak inhibitor monotherapy (OR, 1.82; 95% CI, 1.21-2.73; P = .004) but not among those who received a TNF inhibitor in combination with methotrexate therapy (OR, 1.18; 95% CI, 0.85-1.63; P = .33). Similar findings were obtained in analyses that accounted for potential reporting bias and sensitivity analyses that excluded patients with a COVID-19 diagnosis based on symptoms alone.\n\nIn this cohort study, TNF inhibitor monotherapy was associated with a lower risk of adverse COVID-19 outcomes compared with other commonly prescribed immunomodulatory treatment regimens among individuals with IMIDs.", "doi": "10.1001/jamanetworkopen.2021.29639", "pmid": "34661663", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2785080"}], "notes": [], "created": "2021-10-21T05:00:02.951Z", "modified": "2021-10-21T05:00:02.965Z"}, {"entity": "publication", "iuid": "7fc8b99cd85b4160bbeae8e8055a3a47", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7fc8b99cd85b4160bbeae8e8055a3a47.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7fc8b99cd85b4160bbeae8e8055a3a47"}}, "title": "The use of Faecal Microbiota Transplantation (FMT) in Europe: A Europe-wide survey.", "authors": [{"family": "Baunwall", "given": "Simon Mark Dahl", "initials": "SMD"}, {"family": "Terveer", "given": "Elisabeth M", "initials": "EM"}, {"family": "Dahlerup", "given": "Jens Frederik", "initials": "JF"}, {"family": "Erikstrup", "given": "Christian", "initials": "C"}, {"family": "Arkkila", "given": "Perttu", "initials": "P"}, {"family": "Vehreschild", "given": "Maria Jgt", "initials": "MJ"}, {"family": "Ianiro", "given": "Gianluca", "initials": "G"}, {"family": "Gasbarrini", "given": "Antonio", "initials": "A"}, {"family": "Sokol", "given": "Harry", "initials": "H"}, {"family": "Kump", "given": "Patrizia K", "initials": "PK"}, {"family": "Satokari", "given": "Reetta", "initials": "R"}, {"family": "De Looze", "given": "Danny", "initials": "D"}, {"family": "Vermeire", "given": "S\u00e9verine", "initials": "S"}, {"family": "Nakov", "given": "Radislav", "initials": "R"}, {"family": "Brezina", "given": "Jan", "initials": "J"}, {"family": "Helms", "given": "Morten", "initials": "M"}, {"family": "Kjeldsen", "given": "Jens", "initials": "J"}, {"family": "Rode", "given": "Anne A", "initials": "AA"}, {"family": "Kousgaard", "given": "Sabrina Just", "initials": "SJ"}, {"family": "Alric", "given": "Laurent", "initials": "L"}, {"family": "Trang-Poisson", "given": "Caroline", "initials": "C"}, {"family": "Scanzi", "given": "Julien", "initials": "J"}, {"family": "Link", "given": "Alexander", "initials": "A"}, {"family": "Stallmach", "given": "Andreas", "initials": "A"}, {"family": "Kupcinskas", "given": "Juozas", "initials": "J"}, {"family": "Johnsen", "given": "Peter Holger", "initials": "PH"}, {"family": "Garborg", "given": "Kjetil", "initials": "K"}, {"family": "Rodr\u00edguez", "given": "Eugenia S\u00e1nchez", "initials": "ES"}, {"family": "Serrander", "given": "Lena", "initials": "L"}, {"family": "Brummer", "given": "Robert J", "initials": "RJ"}, {"family": "Galp\u00e9rine", "given": "Katerina Tatiana", "initials": "KT"}, {"family": "Goldenberg", "given": "Simon D", "initials": "SD"}, {"family": "Mullish", "given": "Benjamin H", "initials": "BH"}, {"family": "Williams", "given": "Horace Rt", "initials": "HR"}, {"family": "Iqbal", "given": "Tariq H", "initials": "TH"}, {"family": "Ponsioen", "given": "Cyriel", "initials": "C"}, {"family": "Kuijper", "given": "Ed J", "initials": "EJ"}, {"family": "Cammarota", "given": "Giovanni", "initials": "G"}, {"family": "Keller", "given": "Josbert J", "initials": "JJ"}, {"family": "Hvas", "given": "Christian Lodberg", "initials": "CL"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "9", "pages": "100181", "issn-l": null}, "abstract": "Faecal microbiota transplantation (FMT) is an emerging treatment modality, but its current clinical use and organisation are unknown. We aimed to describe the clinical use, conduct, and potential for FMT in Europe.\n\nWe invited all hospital-based FMT centres within the European Council member states to answer a web-based questionnaire covering their clinical activities, organisation, and regulation of FMT in 2019. Responders were identified from trials registered at clinicaltrials.gov and from the United European Gastroenterology (UEG) working group for stool banking and FMT.\n\nIn 2019, 31 FMT centres from 17 countries reported a total of 1,874 (median 25, quartile 10-64) FMT procedures; 1,077 (57%) with Clostridioides difficile infection (CDI) as indication, 791 (42%) with experimental indications, and 6 (0\u20223%) unaccounted for. Adjusted to population size, 0\u2022257 per 100,000 population received FMT for CDI and 0\u2022189 per 100,000 population for experimental indications. With estimated 12,400 (6,100-28,500) annual cases of multiple, recurrent CDI and indication for FMT in Europe, the current European FMT activity covers approximately 10% of the patients with indication. The participating centres demonstrated high safety standards and adherence to international consensus guidelines. Formal or informal regulation from health authorities was present at 21 (68%) centres.\n\nFMT is a widespread routine treatment for multiple, recurrent CDI and an experimental treatment. Embedded within hospital settings, FMT centres operate with high standards across Europe to provide safe FMT. A significant gap in FMT coverage suggests the need to raise clinical awareness and increase the FMT activity in Europe by at least 10-fold to meet the true, indicated need.\n\nNordForsk under the Nordic Council and Innovation Fund Denmark (j.no. 8056-00006B).", "doi": "10.1016/j.lanepe.2021.100181", "pmid": "34693388", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00158-7"}, {"db": "pmc", "key": "PMC8513118"}], "notes": [], "created": "2021-10-26T18:27:35.950Z", "modified": "2021-10-26T18:27:57.245Z"}, {"entity": "publication", "iuid": "5d42e9f095cf48b98731eed07b48a1a8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d42e9f095cf48b98731eed07b48a1a8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d42e9f095cf48b98731eed07b48a1a8"}}, "title": "Spotlight influenza: The 2019/20 influenza season and the impact of COVID-19 on influenza surveillance in the WHO European Region.", "authors": [{"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Sneiderman", "given": "Miriam", "initials": "M"}, {"family": "Martinuka", "given": "Oksana", "initials": "O"}, {"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Fielding", "given": "James", "initials": "J"}, {"family": "Olsen", "given": "Sonja J", "initials": "SJ"}, {"family": "Penttinen", "given": "Pasi", "initials": "P"}, {"family": "Pastore", "given": "Lucia", "initials": "L"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "European Influenza Surveillance Network", "given": "", "initials": ""}, {"family": "Members of the European Influenza Surveillance Network", "given": "", "initials": ""}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "40", "issn-l": null}, "abstract": "BackgroundAnnual seasonal influenza activity in the northern hemisphere causes a high burden of disease during the winter months, peaking in the first weeks of the year.AimWe describe the 2019/20 influenza season and the impact of the COVID-19 pandemic on sentinel surveillance in the World Health Organization (WHO) European Region.MethodsWe analysed weekly epidemiological and virological influenza data from sentinel primary care and hospital sources reported by countries, territories and areas (hereafter countries) in the European Region.ResultsWe observed co-circulation of influenza B/Victoria-lineage, A(H1)pdm09 and A(H3) viruses during the 2019/20 season, with different dominance patterns observed across the Region. A higher proportion of patients with influenza A virus infection than type B were observed. The influenza activity started in week 47/2019, and influenza positivity rate was \u2265 50% for 2 weeks (05-06/2020) rather than 5-8 weeks in the previous five seasons. In many countries a rapid reduction in sentinel reports and the highest influenza activity was observed in weeks 09-13/2020. Reporting was reduced from week 14/2020 across the Region coincident with the onset of widespread circulation of SARS-CoV-2.ConclusionsOverall, influenza type A viruses dominated; however, there were varying patterns across the Region, with dominance of B/Victoria-lineage viruses in a few countries. The COVID-19 pandemic contributed to an earlier end of the influenza season and reduced influenza virus circulation probably owing to restricted healthcare access and public health measures.", "doi": "10.2807/1560-7917.ES.2021.26.40.2100077", "pmid": "34622760", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:06:43.120Z", "modified": "2021-10-10T15:06:43.131Z"}, {"entity": "publication", "iuid": "52cf49fa75ee488785e083c10c6c9168", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/52cf49fa75ee488785e083c10c6c9168.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/52cf49fa75ee488785e083c10c6c9168"}}, "title": "Soluble angiotensin-converting enzyme 2 is transiently elevated in COVID-19 and correlates with specific inflammatory and endothelial markers.", "authors": [{"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A", "orcid": "0000-0003-1671-0827", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44c5053ce647424f8fd0c263dd655572.json"}}, {"family": "Ziegler", "given": "Louise", "initials": "L"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Rudberg", "given": "Ann-Sofie", "initials": "AS"}, {"family": "von Meijenfeldt", "given": "Fien", "initials": "F"}, {"family": "Lisman", "given": "Ton", "initials": "T"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Sand\u00e9n", "given": "Per", "initials": "P"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "J Med Virol", "issn": "1096-9071", "issn-l": null, "volume": "93", "issue": "10", "pages": "5908-5916"}, "abstract": "The main entry receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is angiotensin-converting enzyme 2 (ACE2). SARS-CoV-2 interactions with ACE2 may increase ectodomain shedding but consequences for the renin-angiotensin system and pathology in Coronavirus disease 2019 (COVID-19) remain unclear. We measured soluble ACE2 (sACE2) and sACE levels by enzyme-linked immunosorbent assay in 114 hospital-treated COVID-19 patients compared with 10 healthy controls; follow-up samples after four months were analyzed for 58 patients. Associations between sACE2 respectively sACE and risk factors for severe COVID-19, outcome, and inflammatory markers were investigated. Levels of sACE2 were higher in COVID-19 patients than in healthy controls, median 5.0 (interquartile range 2.8-11.8) ng/ml versus 1.4 (1.1-1.6) ng/ml, p < .0001. sACE2 was higher in men than women but was not affected by other risk factors for severe COVID-19. sACE2 decreased to 2.3 (1.6-3.9) ng/ml at follow-up, p < .0001, but remained higher than in healthy controls, p = .012. sACE was marginally lower during COVID-19 compared with at follow-up, 57 (45-70) ng/ml versus 72 (52-87) ng/ml, p = .008. Levels of sACE2 and sACE did not differ depending on survival or disease severity. sACE2 during COVID-19 correlated with von Willebrand factor, factor VIII and D-dimer, while sACE correlated with interleukin 6, tumor necrosis factor \u03b1, and plasminogen activator inhibitor 1. Conclusions: sACE2 was transiently elevated in COVID-19, likely due to increased shedding from infected cells. sACE2 and sACE during COVID-19 differed in correlations with markers of inflammation and endothelial dysfunction, suggesting release from different cell types and/or vascular beds.", "doi": "10.1002/jmv.27144", "pmid": "34138483", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC8426677"}], "notes": [], "created": "2021-06-28T18:38:59.230Z", "modified": "2021-12-12T18:08:59.955Z"}, {"entity": "publication", "iuid": "01ea523b4e384149a00f4668eae77d0b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01ea523b4e384149a00f4668eae77d0b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01ea523b4e384149a00f4668eae77d0b"}}, "title": "Serum Neurofilament Light is elevated in COVID-19 Positive Adults in the ICU and is associated with Co-Morbid Cardiovascular Disease, Neurological Complications, and Acuity of Illness.", "authors": [{"family": "Hay", "given": "Meredith", "initials": "M"}, {"family": "Ryan", "given": "Lee", "initials": "L"}, {"family": "Huentelman", "given": "Matthew", "initials": "M"}, {"family": "Konhilas", "given": "John", "initials": "J"}, {"family": "Hoyer-Kimura", "given": "Christina", "initials": "C"}, {"family": "Beach", "given": "Thomas G", "initials": "TG"}, {"family": "Serrano", "given": "Geidy E", "initials": "GE"}, {"family": "Reiman", "given": "Eric M", "initials": "EM"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Parthasarathy", "given": "Sairam", "initials": "S"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Cardiol Cardiovasc Med", "issn": "2572-9292", "volume": "5", "issue": "5", "pages": "551-565", "issn-l": null}, "abstract": "In critically ill COVID-19 patients, the risk of long-term neurological consequences is just beginning to be appreciated. While recent studies have identified that there is an increase in structural injury to the nervous system in critically ill COVID-19 patients, there is little known about the relationship of COVID-19 neurological damage to the systemic inflammatory diseases also observed in COVID-19 patients. The purpose of this pilot observational study was to examine the relationships between serum neurofilament light protein (NfL, a measure of neuronal injury) and co-morbid cardiovascular disease (CVD) and neurological complications in COVID-19 positive patients admitted to the intensive care unit (ICU). In this observational study of one-hundred patients who were admitted to the ICU in Tucson, Arizona between April and August 2020, 89 were positive for COVID-19 (COVID-pos) and 11 was COVID-negative (COVID-neg). A healthy control group (n=8) was examined for comparison. The primary outcomes and measures were subject demographics, serum NfL, presence and extent of CVD, diabetes, sequential organ failure assessment score (SOFA), presence of neurological complications, and blood chemistry panel data. COVID-pos patients in the ICU had significantly higher mean levels of Nfl (229.6 \u00b1 163 pg/ml) compared to COVID-neg ICU patients (19.3 \u00b1 5.6 pg/ml), Welch's t-test, p =.01 and healthy controls (12.3 \u00b1 3.1 pg/ml), Welch's t-test p =.005. Levels of Nfl in COVID-pos ICU patients were significantly higher in patients with concomitant CVD and diabetes (n=35, log Nfl 1.6\u00b1.09), and correlated with higher SOFA scores (r=.5, p =.001). These findings suggest that in severe COVID-19 disease, the central neuronal and axonal damage in these patients may be driven, in part, by the level of systemic cardiovascular disease and peripheral inflammation. Understanding the contributions of systemic inflammatory disease to central neurological degeneration in these COVID-19 survivors will be important to the design of interventional therapies to prevent long-term neurological and cognitive dysfunction.", "doi": "10.26502/fccm.92920221", "pmid": "34708189", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "mid", "key": "NIHMS1747952"}, {"db": "pmc", "key": "PMC8547787"}], "notes": [], "created": "2021-11-01T19:47:57.104Z", "modified": "2023-06-19T15:21:50.201Z"}, {"entity": "publication", "iuid": "9946b87cc5bd4651ae99d7288a850d43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9946b87cc5bd4651ae99d7288a850d43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9946b87cc5bd4651ae99d7288a850d43"}}, "title": "Sensing Inflammation Biomarkers with Electrolyte-Gated Organic Electronic Transistors.", "authors": [{"family": "Burtscher", "given": "Bernhard", "initials": "B", "orcid": "0000-0002-6394-2965", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/775b6ad4fdd94a49be50ac83e6fe8a95.json"}}, {"family": "Manco Urbina", "given": "Pamela Allison", "initials": "PA", "orcid": "0000-0002-3687-9374", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28ab31b512ad40de91c56fd73276984b.json"}}, {"family": "Diacci", "given": "Chiara", "initials": "C", "orcid": "0000-0002-2724-5601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa70b059609b44d8bf593f50cd699e52.json"}}, {"family": "Borghi", "given": "Simone", "initials": "S"}, {"family": "Pinti", "given": "Marcello", "initials": "M", "orcid": "0000-0001-9118-1262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10ebafa0cfa8439a8ffac27e8bdd120c.json"}}, {"family": "Cossarizza", "given": "Andrea", "initials": "A", "orcid": "0000-0002-5381-1558", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/916b3aa37d1744669bc10dd62e1cf8e7.json"}}, {"family": "Salvarani", "given": "Carlo", "initials": "C"}, {"family": "Berggren", "given": "Magnus", "initials": "M", "orcid": "0000-0001-5154-0291", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5fe2982d17543c480280343ade44a80.json"}}, {"family": "Biscarini", "given": "Fabio", "initials": "F", "orcid": "0000-0001-6648-5803", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e151476689844559964e691404f10b86.json"}}, {"family": "Simon", "given": "Daniel T", "initials": "DT", "orcid": "0000-0002-2799-3490", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21fd8689ce8c4a2fa58fb71b5118ae8b.json"}}, {"family": "Bortolotti", "given": "Carlo A", "initials": "CA", "orcid": "0000-0002-5701-5727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d460780d1154424e898f79de064fc43d.json"}}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Adv Healthc Mater", "issn": "2192-2659", "issn-l": null, "volume": "10", "issue": "20", "pages": "e2100955"}, "abstract": "An overview of cytokine biosensing is provided, with a focus on the opportunities provided by organic electronic platforms for monitoring these inflammation biomarkers which manifest at ultralow concentration levels in physiopathological conditions. Specifically, two of the field's state-of-the-art technologies-organic electrochemical transistors (OECTs) and electrolyte gated organic field effect transistors (EGOFETs)-and their use in sensing cytokines and other proteins associated with inflammation are a particular focus. The overview will include an introduction to current clinical and \"gold standard\" quantification techniques and their limitations in terms of cost, time, and required infrastructure. A critical review of recent progress with OECT- and EGOFET-based protein biosensors is presented, alongside a discussion onthe future of these technologies in the years and decades ahead. This is especially timely as the world grapples with limited healthcare diagnostics during the Coronavirus disease (COVID-19)pandemic where one of the worst-case scenarios for patients is the \"cytokine storm.\" Clearly, low-cost point-of-care technologies provided by OECTs and EGOFETs can ease the global burden on healthcare systems and support professionals by providing unprecedented wealth of data that can help to monitor disease progression in real time.", "doi": "10.1002/adhm.202100955", "pmid": "34423579", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-08-27T09:41:17.223Z", "modified": "2021-11-18T13:40:51.005Z"}, {"entity": "publication", "iuid": "fe3461dafb2240a49bb2996b40ff380c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fe3461dafb2240a49bb2996b40ff380c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fe3461dafb2240a49bb2996b40ff380c"}}, "title": "Parent-adolescent relationship quality as a moderator of links between COVID-19 disruption and reported changes in mothers' and young adults' adjustment in five countries.", "authors": [{"family": "Skinner", "given": "Ann T", "initials": "AT", "orcid": "0000-0001-8083-9487", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9bffc80b3a4b46789e77b9c9ea4203e6.json"}}, {"family": "Godwin", "given": "Jennifer", "initials": "J", "orcid": "0000-0001-5258-1351", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/abcc5b41ac7f4a7ebfebc17357ea4572.json"}}, {"family": "Alampay", "given": "Liane Pe\u00f1a", "initials": "LP", "orcid": "0000-0002-5760-6711", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39138bdb521f47d48ca20c6fd5097285.json"}}, {"family": "Lansford", "given": "Jennifer E", "initials": "JE", "orcid": "0000-0003-1956-4917", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/099f957450e743acab538878cc487a27.json"}}, {"family": "Bacchini", "given": "Dario", "initials": "D", "orcid": "0000-0001-6140-9377", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/087d86a987214e3e8b685b9dd31e4ccd.json"}}, {"family": "Bornstein", "given": "Marc H", "initials": "MH"}, {"family": "Deater-Deckard", "given": "Kirby", "initials": "K", "orcid": "0000-0003-4151-2152", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/211fa4b8046243e8b96ed9460dccd222.json"}}, {"family": "Di Giunta", "given": "Laura", "initials": "L"}, {"family": "Dodge", "given": "Kenneth A", "initials": "KA", "orcid": "0000-0001-5932-215X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68152786a6394d79b8261287f8020279.json"}}, {"family": "Gurdal", "given": "Sevtap", "initials": "S", "orcid": "0000-0001-7881-5670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3aa5a20191b040fc8d432e7deea46c90.json"}}, {"family": "Pastorelli", "given": "Concetta", "initials": "C", "orcid": "0000-0003-2837-7312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e126c726417442bafb6eb57680a7032.json"}}, {"family": "Sorbring", "given": "Emma", "initials": "E"}, {"family": "Steinberg", "given": "Laurence", "initials": "L"}, {"family": "Tapanya", "given": "Sombat", "initials": "S", "orcid": "0000-0002-2461-6593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eed362b8f81241e1a43f524c3f2b0c3d.json"}}, {"family": "Yotanyamaneewong", "given": "Saengduean", "initials": "S"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Dev Psychol", "issn": "1939-0599", "volume": "57", "issue": "10", "pages": "1648-1666", "issn-l": null}, "abstract": "The COVID-19 pandemic has presented families around the world with extraordinary challenges related to physical and mental health, economic security, social support, and education. The current study capitalizes on a longitudinal, cross-national study of parenting, adolescent development, and young adult competence to document the association between personal disruption during the pandemic and reported changes in internalizing and externalizing behavior in young adults and their mothers since the pandemic began. It further investigates whether family functioning during adolescence 3 years earlier moderates this association. Data from 484 families in five countries (Italy, the Philippines, Sweden, Thailand, and the United States) reveal that higher levels of reported disruption during the pandemic are related to reported increases in internalizing and externalizing behaviors after the onset of the COVID-19 pandemic for young adults (Mage = 20) and their mothers in all five countries, with the exception of one association in Thailand. Associations between disruption during the pandemic and young adults' and their mothers' reported increases in internalizing and externalizing behaviors were attenuated by higher levels of youth disclosure, more supportive parenting, and lower levels of destructive adolescent-parent conflict prior to the pandemic. This work has implications for fostering parent-child relationships characterized by warmth, acceptance, trust, open communication, and constructive conflict resolution at all times given their protective effects for family resilience during times of crisis. (PsycInfo Database Record (c) 2021 APA, all rights reserved).", "doi": "10.1037/dev0001236", "pmid": "34807687", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2022-06056-008"}], "notes": [], "created": "2021-11-26T13:55:20.287Z", "modified": "2021-11-26T13:55:20.643Z"}, {"entity": "publication", "iuid": "ec27250dd69044d38fecd673f5baf25d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec27250dd69044d38fecd673f5baf25d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec27250dd69044d38fecd673f5baf25d"}}, "title": "Organisational Response Strategies to COVID-19 in the Sharing Economy.", "authors": [{"family": "Mont", "given": "Oksana", "initials": "O"}, {"family": "Curtis", "given": "Steven Kane", "initials": "SK"}, {"family": "Voytenko Palgan", "given": "Yuliya", "initials": "Y"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Sustain Prod Consum", "issn": "2352-5509", "volume": "28", "pages": "52-70", "issn-l": null}, "abstract": "The COVID-19 pandemic has impacted production and consumption patterns across the world and forced many organisations to respond. However, there is a lack of understanding as to how sharing platforms have been affected by the pandemic, how they responded to the crisis, and what kinds of long-term implications the pandemic may have on the sharing economy. This study combined systematic literature review and qualitative web analysis of 30 mobility, space, and goods sharing platforms of different business models and geographies. An empirically-driven framework of organisational responses to COVID-19 was developed that comprises eight overarching response strategies targeting the organisation, users, and society. It is a novel framework that structures organisational responses to a high-impact, low-probability crisis. This study also discusses the long-term implications of the COVID-19 pandemic on the sharing economy, and explores how this may impact future responses among sharing platforms in the society that seeks sustainability. The learnings of this study have real-world significance. Sharing platforms can learn from each other about how to continue to respond in the face of the ongoing pandemic, and consider actions for future preparedness to potential forthcoming crises. With this we hope to encourage perseverance, long-term viability, sustainability, and resilience in organisations that may offer more sustainable ways of consumption and production.", "doi": "10.1016/j.spc.2021.03.025", "pmid": "34786447", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2352-5509(21)00098-1"}, {"db": "pmc", "key": "PMC8581630"}], "notes": [], "created": "2021-11-26T14:11:21.267Z", "modified": "2021-11-26T14:11:21.302Z"}, {"entity": "publication", "iuid": "4af14da35f39433b9b62419f6e6082e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4af14da35f39433b9b62419f6e6082e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4af14da35f39433b9b62419f6e6082e2"}}, "title": "Occupational risk of COVID-19 in the first versus second epidemic wave in Norway, 2020.", "authors": [{"family": "Magnusson", "given": "Karin", "initials": "K"}, {"family": "Nyg\u00e5rd", "given": "Karin", "initials": "K"}, {"family": "Methi", "given": "Fredrik", "initials": "F"}, {"family": "Vold", "given": "Line", "initials": "L"}, {"family": "Telle", "given": "Kjetil", "initials": "K"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "40", "issn-l": null}, "abstract": "BackgroundThe occupational risk of COVID-19 may be different in the first versus second epidemic wave.AimTo study whether employees in occupations that typically entail close contact with others were at higher risk of SARS-CoV-2 infection and COVID-19-related hospitalisation during the first and second epidemic wave before and after 18 July 2020, in Norway.MethodsWe included individuals in occupations working with patients, children, students, or customers using Standard Classification of Occupations (ISCO-08) codes. We compared residents (3,559,694 on 1 January 2020) in such occupations aged 20-70 years (mean: 44.1; standard deviation: 14.3 years; 51% men) to age-matched individuals in other professions using logistic regression adjusted for age, sex, birth country and marital status.ResultsNurses, physicians, dentists and physiotherapists had 2-3.5 times the odds of COVID-19 during the first wave when compared with others of working age. In the second wave, bartenders, waiters, food counter attendants, transport conductors, travel stewards, childcare workers, preschool and primary school teachers had ca 1.25-2 times the odds of infection. Bus, tram and taxi drivers had an increased odds of infection in both waves (odds ratio: 1.2-2.1). Occupation was of limited relevance for the odds of severe infection, here studied as hospitalisation with the disease.ConclusionOur findings from the entire Norwegian population may be of relevance to national and regional authorities in handling the epidemic. Also, we provide a knowledge foundation for more targeted future studies of lockdowns and disease control measures.", "doi": "10.2807/1560-7917.ES.2021.26.40.2001875", "pmid": "34622761", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:06:17.118Z", "modified": "2021-10-10T15:06:17.128Z"}, {"entity": "publication", "iuid": "9741f4d2903843baa47aa592053d5733", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9741f4d2903843baa47aa592053d5733.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9741f4d2903843baa47aa592053d5733"}}, "title": "Neurochemical biomarkers to study CNS effects of COVID-19: A narrative review and synthesis.", "authors": [{"family": "Ed\u00e9n", "given": "Arvid", "initials": "A", "orcid": "0000-0003-2817-9981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54411b4f4cbe422697c5eb3080c23e2c.json"}}, {"family": "Simr\u00e9n", "given": "Joel", "initials": "J", "orcid": "0000-0001-5081-6604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00690c8e16a545aea824cdf580837500.json"}}, {"family": "Price", "given": "Richard W", "initials": "RW"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e314740b02c344d2b336a9410e28041e.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "J Neurochem", "issn": "0022-3042", "issn-l": null, "volume": "159", "issue": "1", "pages": "61-77"}, "abstract": "Neurological symptoms are frequently reported in patients suffering from COVID-19. Common CNS-related symptoms include anosmia, caused by viral interaction with either neurons or supporting cells in nasal olfactory tissues. Diffuse encephalopathy is the most common sign of CNS dysfunction, which likely results from the CNS consequences of the systemic inflammatory syndrome associated with severe COVID-19. Additionally, microvascular injuries and thromboembolic events likely contribute to the neurologic impact of acute COVID-19. These observations are supported by evidence of CNS immune activation in cerebrospinal fluid (CSF) and in autopsy tissue, along with the detection of microvascular injuries in both pathological and neuroimaging studies. The frequent occurrence of thromboembolic events in patients with COVID-19 has generated different hypotheses, among which viral interaction with perivascular cells is particularly attractive, yet unproven. A distinguishing feature of CSF findings in SARS-CoV-2 infection is that clinical signs characteristic of neurotropic viral infections (CSF pleocytosis and blood-brain barrier injury) are mild or absent. Moreover, virus detection in CSF is rare and often of uncertain significance. In this review, we provide an overview of the neurological impact that occurs in the acute phase of COVID-19, and the role of CSF biomarkers in the clinical management and research to better treat and understand the disease. In addition to aiding as diagnostic and prognostic tools during acute infection, the use of comprehensive and well-characterized CSF and blood biomarkers will be vital in understanding the potential impact on the CNS in the rapidly increasing number of individuals recovering from COVID-19.", "doi": "10.1111/jnc.15459", "pmid": "34170549", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8420435"}], "notes": [], "created": "2021-06-28T18:12:28.285Z", "modified": "2023-06-19T14:46:17.609Z"}, {"entity": "publication", "iuid": "50547a0d81b74ad4b26b3bcc59ab4b29", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50547a0d81b74ad4b26b3bcc59ab4b29.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50547a0d81b74ad4b26b3bcc59ab4b29"}}, "title": "Increase in invasive disease caused by Haemophilus influenzae b, the Netherlands, 2020 to 2021.", "authors": [{"family": "Steens", "given": "Anneke", "initials": "A"}, {"family": "Stanoeva", "given": "Kamelia R", "initials": "KR"}, {"family": "Knol", "given": "Mirjam J", "initials": "MJ"}, {"family": "Mariman", "given": "Rob", "initials": "R"}, {"family": "de Melker", "given": "Hester E", "initials": "HE"}, {"family": "van Sorge", "given": "Nina M", "initials": "NM"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "42", "issn-l": null}, "abstract": "The incidence of most respiratory-transmitted diseases decreased during the COVID-19 pandemic as a result of containment measures. In contrast, in the Netherlands we noted an increase in invasive disease caused by Haemophilus influenzae b (Hib) (from < 0.3/100,000 before 2019 to 0.39 and 0.33/100,000 in 2020 and 2021) in vaccinated and unvaccinated age groups. We did not find a change in vaccine effectiveness against Hib invasive disease (effectiveness > 90%). We discuss factors that may have contributed to this rise.", "doi": "10.2807/1560-7917.ES.2021.26.42.2100956", "pmid": "34676819", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:12:02.433Z", "modified": "2021-10-26T18:12:02.449Z"}, {"entity": "publication", "iuid": "264e8f754e3946e2989b2a9c23cbe27b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/264e8f754e3946e2989b2a9c23cbe27b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/264e8f754e3946e2989b2a9c23cbe27b"}}, "title": "HMG-CoA reductase inhibitors and COVID-19 mortality in Stockholm, Sweden: A registry-based cohort study.", "authors": [{"family": "Bergqvist", "given": "Rita", "initials": "R"}, {"family": "Ahlqvist", "given": "Viktor H", "initials": "VH", "orcid": "0000-0003-1383-3194", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90ca532443fd48bf801018fc17345726.json"}}, {"family": "Lundberg", "given": "Michael", "initials": "M"}, {"family": "Hergens", "given": "Maria-Pia", "initials": "MP", "orcid": "0000-0001-5397-3541", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11f60a8ed4e849fab81602d86dce5819.json"}}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2c4588f000c470abf08f2e40852b6d1.json"}}, {"family": "Bell", "given": "Max", "initials": "M", "orcid": "0000-0001-7464-0324", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/530f7609a1f143b69691db5c41b14412.json"}}, {"family": "Magnusson", "given": "Cecilia", "initials": "C"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "PLoS Med", "issn": "1549-1676", "volume": "18", "issue": "10", "pages": "e1003820", "issn-l": "1549-1277"}, "abstract": "The relationship between statin treatment and Coronavirus Disease 2019 (COVID-19) mortality has been discussed due to the pleiotropic effects of statins on coagulation and immune mechanisms. However, available observational studies are hampered by study design flaws, resulting in substantial heterogeneity and ambiguities. Here, we aim to determine the relationship between statin treatment and COVID-19 mortality.\n\nThis cohort study included all Stockholm residents aged 45 or older (N = 963,876), followed up from 1 March 2020 until 11 November 2020. The exposure was statin treatment initiated before the COVID-19-pandemic, defined as recorded statin dispensation in the Swedish Prescribed Drug Register between 1 March 2019 and 29 February 2020. COVID-19-specific mortality was ascertained from the Swedish Cause of Death Registry. Hazard ratios (HRs) were calculated using multivariable Cox regression models. We further performed a target trial emulation restricted to initiators of statins. In the cohort (51.6% female), 169,642 individuals (17.6%) were statin users. Statin users were older (71.0 versus 58.0 years), more likely to be male (53.3% versus 46.7%), more often diagnosed with comorbidities (for example, ischemic heart disease 23.3% versus 1.6%), more frequently on anticoagulant and antihypertensive treatments, less likely to have a university-level education (34.5% versus 45.4%), and more likely to have a low disposable income (20.6% versus 25.2%), but less likely to reside in crowded housing (6.1% versus 10.3%). A total of 2,545 individuals died from COVID-19 during follow-up, including 765 (0.5%) of the statin users and 1,780 (0.2%) of the nonusers. Statin treatment was associated with a lowered COVID-19 mortality (adjusted HR, 0.88; 95% CI, 0.79 to 0.97, P = 0.01), and this association did not vary appreciably across age groups, sexes, or COVID-19 risk groups. The confounder adjusted HR for statin treatment initiators was 0.78 (95% CI, 0.59 to 1.05, P = 0.10) in the emulated target trial. Limitations of this study include the observational design, reliance on dispensation data, and the inability to study specific drug regimens.\n\nStatin treatment had a modest negative association with COVID-19 mortality. While this finding needs confirmation from randomized clinical trials, it supports the continued use of statin treatment for medical prevention according to current recommendations also during the COVID-19 pandemic.", "doi": "10.1371/journal.pmed.1003820", "pmid": "34648516", "labels": {"Category: Health": null, "Type: Journal article": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC8516243"}, {"db": "pii", "key": "PMEDICINE-D-21-02232"}], "notes": [], "created": "2021-10-21T05:06:28.806Z", "modified": "2023-01-13T14:42:42.766Z"}, {"entity": "publication", "iuid": "070a956c8f97485fbf74e03ed65eb838", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/070a956c8f97485fbf74e03ed65eb838.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/070a956c8f97485fbf74e03ed65eb838"}}, "title": "Factors for severe outcomes following SARS-CoV-2 infection in people with cystic fibrosis in Europe.", "authors": [{"family": "Jung", "given": "Andreas", "initials": "A", "orcid": "0000-0002-3505-6691", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00c3b50ae199470f9bbc3b6bab2a599d.json"}}, {"family": "Orenti", "given": "Annalisa", "initials": "A", "orcid": "0000-0002-0932-2757", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/962bc29291b04906a8412549987b427c.json"}}, {"family": "Dunlevy", "given": "Fiona", "initials": "F"}, {"family": "Aleksejeva", "given": "Elina", "initials": "E"}, {"family": "Bakkeheim", "given": "Egil", "initials": "E"}, {"family": "Bobrovnichy", "given": "Vladimir", "initials": "V"}, {"family": "Carr", "given": "Siobh\u00e1n B", "initials": "SB", "orcid": "0000-0003-0580-2478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37c62afad5b0418795bcc11860e944d5.json"}}, {"family": "Colombo", "given": "Carla", "initials": "C"}, {"family": "Corvol", "given": "Harriet", "initials": "H", "orcid": "0000-0002-7026-7523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3dc3bf5305094e88997c92b54ffda9b8.json"}}, {"family": "Cosgriff", "given": "Rebecca", "initials": "R"}, {"family": "Daneau", "given": "G\u00e9raldine", "initials": "G", "orcid": "0000-0002-2570-0893", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/352fa7a9aff1450691a070874ce7939a.json"}}, {"family": "Dogru", "given": "Deniz", "initials": "D", "orcid": "0000-0001-9931-9473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf97852882d74bd98670c8b89f743baa.json"}}, {"family": "Drevinek", "given": "Pavel", "initials": "P"}, {"family": "Vukic", "given": "Andrea Dugac", "initials": "AD"}, {"family": "Fajac", "given": "Isabelle", "initials": "I"}, {"family": "Fox", "given": "Alice", "initials": "A"}, {"family": "Fustik", "given": "Stojka", "initials": "S"}, {"family": "Gulmans", "given": "Vincent", "initials": "V"}, {"family": "Harutyunyan", "given": "Satenik", "initials": "S"}, {"family": "Hatziagorou", "given": "Elpis", "initials": "E"}, {"family": "Kasmi", "given": "Irena", "initials": "I"}, {"family": "Kayserov\u00e1", "given": "Hana", "initials": "H"}, {"family": "Kondratyeva", "given": "Elena", "initials": "E"}, {"family": "Krivec", "given": "Uro\u0161", "initials": "U", "orcid": "0000-0001-9031-5708", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c56e1173942d414f9bee9e0b7006273e.json"}}, {"family": "Makukh", "given": "Halyna", "initials": "H"}, {"family": "Malakauskas", "given": "Kestutis", "initials": "K"}, {"family": "McKone", "given": "Edward F", "initials": "EF"}, {"family": "Mei-Zahav", "given": "Meir", "initials": "M"}, {"family": "de Monestrol", "given": "Isabelle", "initials": "I"}, {"family": "Olesen", "given": "Hanne Vebert", "initials": "HV"}, {"family": "Padoan", "given": "Rita", "initials": "R"}, {"family": "Parulava", "given": "Tsitsino", "initials": "T", "orcid": "0000-0003-2467-7940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ef1c5c5029f47588fb30cbf14f2c597.json"}}, {"family": "Pastor-Vivero", "given": "Maria Dolores", "initials": "MD", "orcid": "0000-0001-8917-4709", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9014de29de4dab95548371cdc7e217.json"}}, {"family": "Pereira", "given": "Lu\u00edsa", "initials": "L"}, {"family": "Petrova", "given": "Guergana", "initials": "G"}, {"family": "Pfleger", "given": "Andreas", "initials": "A"}, {"family": "Pop", "given": "Liviu", "initials": "L"}, {"family": "van Rens", "given": "Jacqui G", "initials": "JG"}, {"family": "Rodic", "given": "Milan", "initials": "M"}, {"family": "Schlesser", "given": "Marc", "initials": "M"}, {"family": "Storms", "given": "Val\u00e9rie", "initials": "V", "orcid": "0000-0001-9344-0248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8126464b476e4745b3b2120dac24b72f.json"}}, {"family": "Turcu", "given": "Oxana", "initials": "O"}, {"family": "Woz Niacki", "given": "Lukasz", "initials": "L"}, {"family": "Yiallouros", "given": "Panayiotis", "initials": "P"}, {"family": "Zolin", "given": "Anna", "initials": "A"}, {"family": "Downey", "given": "Damian G", "initials": "DG"}, {"family": "Naehrlich", "given": "Lutz", "initials": "L"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "ERJ Open Res", "issn": "2312-0541", "volume": "7", "issue": "4", "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in people with cystic fibrosis (pwCF) can lead to severe outcomes.\n\nIn this observational study, the European Cystic Fibrosis Society Patient Registry collected data on pwCF and SARS-CoV-2 infection to estimate incidence, describe clinical presentation and investigate factors associated with severe outcomes using multivariable analysis.\n\nUp to December 31, 2020, 26 countries reported information on 828 pwCF and SARS-CoV-2 infection. Incidence was 17.2 per 1000 pwCF (95% CI: 16.0-18.4). Median age was 24 years, 48.4% were male and 9.4% had lung transplants. SARS-CoV-2 incidence was higher in lung-transplanted (28.6; 95% CI: 22.7-35.5) versus non-lung-transplanted pwCF (16.6; 95% CI: 15.4-17.8) (p\u22640.001).SARS-CoV-2 infection caused symptomatic illness in 75.7%. Factors associated with symptomatic SARS-CoV-2 infection were age >40 years, at least one F508del mutation and pancreatic insufficiency.Overall, 23.7% of pwCF were admitted to hospital, 2.5% of those to intensive care, and regretfully 11 (1.4%) died. Hospitalisation, oxygen therapy, intensive care, respiratory support and death were 2- to 6-fold more frequent in lung-transplanted versus non-lung-transplanted pwCF.Factors associated with hospitalisation and oxygen therapy were lung transplantation, cystic fibrosis-related diabetes (CFRD), moderate or severe lung disease and azithromycin use (often considered a surrogate marker for Pseudomonas aeruginosa infection and poorer lung function).\n\nSARS-CoV-2 infection yielded high morbidity and hospitalisation in pwCF. PwCF with forced expiratory volume in 1 s <70% predicted, CFRD and those with lung transplants are at particular risk of more severe outcomes.", "doi": "10.1183/23120541.00411-2021", "pmid": "34984210", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00411-2021"}, {"db": "pmc", "key": "PMC8557394"}], "notes": [], "created": "2022-01-10T15:34:09.247Z", "modified": "2022-01-10T15:34:09.603Z"}, {"entity": "publication", "iuid": "23e85d99f304475997ae98f01d623822", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23e85d99f304475997ae98f01d623822.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23e85d99f304475997ae98f01d623822"}}, "title": "Envisioning a resilient future for biodiversity conservation in the wake of the COVID-19 pandemic.", "authors": [{"family": "Thurstan", "given": "Ruth H", "initials": "RH", "orcid": "0000-0002-8045-1631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fcb1b48a6fa348d1b0a06f61557d25c2.json"}}, {"family": "Hockings", "given": "Kimberley J", "initials": "KJ", "orcid": "0000-0002-6187-644X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6488f4e007a4830a82eb835a00e807d.json"}}, {"family": "Hedlund", "given": "Johanna S U", "initials": "JSU", "orcid": "0000-0001-5826-9588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8ef2989b3e746898de804b994d7dce5.json"}}, {"family": "Bersacola", "given": "Elena", "initials": "E", "orcid": "0000-0003-3814-8687", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2043264a8a3433e8b7bca33dee4382d.json"}}, {"family": "Collins", "given": "Claire", "initials": "C", "orcid": "0000-0001-8651-7219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d94fde481994e4f8d0214e4b3a08f76.json"}}, {"family": "Early", "given": "Regan", "initials": "R", "orcid": "0000-0003-4108-5904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6de473963b89421bb2904cc6345af2b7.json"}}, {"family": "Ermiasi", "given": "Yunsiska", "initials": "Y"}, {"family": "Fleischer-Dogley", "given": "Frauke", "initials": "F"}, {"family": "Gilkes", "given": "Gabriella", "initials": "G"}, {"family": "Harrison", "given": "Mark E", "initials": "ME", "orcid": "0000-0002-0729-8407", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc453216906d43b4b6139edf47a8ce95.json"}}, {"family": "Imron", "given": "Muhammad Ali", "initials": "MA", "orcid": "0000-0003-2371-7795", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e3434f5422842ffbb00a3cc22eb6f46.json"}}, {"family": "Kaiser-Bunbury", "given": "Christopher N", "initials": "CN", "orcid": "0000-0001-7254-3491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02a818e22a9440dea2df7ffd2a0732c6.json"}}, {"family": "Refly Katoppo", "given": "Daniel", "initials": "D"}, {"family": "Marriott", "given": "Cheryl", "initials": "C"}, {"family": "Muzungaile", "given": "Marie-May", "initials": "M"}, {"family": "Nuno", "given": "Ana", "initials": "A", "orcid": "0000-0003-4680-2378", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f710f96931dc49cda3b9949632fc6a7a.json"}}, {"family": "Regalla de Barros", "given": "Aissa", "initials": "A"}, {"family": "van Veen", "given": "Frank", "initials": "F", "orcid": "0000-0003-0708-5492", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/372d44cb6cf541228033a0d8ae879bf7.json"}}, {"family": "Wijesundara", "given": "Isuru", "initials": "I", "orcid": "0000-0001-8200-458X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52efefa366fc403fb63908c962e9e373.json"}}, {"family": "Dogley", "given": "Didier", "initials": "D"}, {"family": "Bunbury", "given": "Nancy", "initials": "N", "orcid": "0000-0002-5836-5497", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7427d5c15b5c44ef807df90170dca752.json"}}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "People Nat (Hoboken)", "issn": "2575-8314", "issn-l": null, "volume": "3", "issue": "5", "pages": "990-1013"}, "abstract": "As the COVID-19 pandemic continues to affect societies across the world, the ongoing economic and social disruptions are likely to present fundamental challenges for current and future biodiversity conservation.We review the literature for outcomes of past major societal, political, economic and zoonotic perturbations on biodiversity conservation, and demonstrate the complex implications of perturbation events upon conservation efforts. Building on the review findings, we use six in-depth case studies and the emerging literature to identify positive and negative outcomes of the COVID-19 pandemic, known and anticipated, for biodiversity conservation efforts around the world.A number of similarities exist between the current pandemic and past perturbations, with experiences highlighting that the pandemic-induced declines in conservation revenue and capacity, livelihood and trade disruptions are likely to have long-lasting and negative implications for biodiversity and conservation efforts.Yet, the COVID-19 pandemic also brought about a global pause in human movement that is unique in recent history, and may yet foster long-lasting behavioural and societal changes, presenting opportunities to strengthen and advance conservation efforts in the wake of the pandemic. Enhanced collaborations and partnerships at the local level, cross-sectoral engagement, local investment and leadership will all enhance the resilience of conservation efforts in the face of future perturbations. Other actions aimed at enhancing resilience will require fundamental institutional change and extensive government and public engagement and support if they are to be realised.The pandemic has highlighted the inherent vulnerabilities in the social and economic models upon which many conservation efforts are based. In so doing, it presents an opportunity to reconsider the status quo for conservation, and promotes behaviours and actions that are resilient to future perturbation. A free Plain Language Summary can be found within the Supporting Information of this article.", "doi": "10.1002/pan3.10262", "pmid": "34909607", "labels": {"Type: Review": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PAN310262"}, {"db": "pmc", "key": "PMC8661774"}], "notes": [], "created": "2021-12-18T17:50:19.313Z", "modified": "2022-02-17T10:13:54.308Z"}, {"entity": "publication", "iuid": "f4b78ade978c41bf8c14690408b3b554", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f4b78ade978c41bf8c14690408b3b554.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f4b78ade978c41bf8c14690408b3b554"}}, "title": "Diabetes, hypertension, body mass index, smoking and COVID-19-related mortality: a systematic review and meta-analysis of observational studies", "authors": [{"family": "Mahamat-Saleh", "given": "Yahya", "initials": "Y", "orcid": "0000-0002-5892-8886", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9ac3af0c6f044d1b10c29683467d030.json"}}, {"family": "Fiolet", "given": "Thibault", "initials": "T"}, {"family": "Rebeaud", "given": "Mathieu Edouard", "initials": "ME"}, {"family": "Mulot", "given": "Matthieu", "initials": "M"}, {"family": "Guihur", "given": "Anthony", "initials": "A", "orcid": "0000-0001-5353-1428", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9949ce6f1c3744e1b127ab415b2a7470.json"}}, {"family": "El Fatouhi", "given": "Douae", "initials": "D"}, {"family": "Laouali", "given": "Nasser", "initials": "N"}, {"family": "Peiffer-Smadja", "given": "Nathan", "initials": "N"}, {"family": "Aune", "given": "Dagfinn", "initials": "D", "orcid": "0000-0002-4533-1722", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3d9e8a2005a4e6fa5fe266389bf80c0.json"}}, {"family": "Severi", "given": "Gianluca", "initials": "G"}], "type": "journal-article", "published": "2021-10-00", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "10", "pages": "e052777"}, "abstract": null, "doi": "10.1136/bmjopen-2021-052777", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:33:43.138Z", "modified": "2022-02-17T09:57:52.122Z"}, {"entity": "publication", "iuid": "84bae0b622bf41e7ab85af7ea3fd45a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84bae0b622bf41e7ab85af7ea3fd45a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84bae0b622bf41e7ab85af7ea3fd45a4"}}, "title": "Cross-sectional examination of 24-hour movement behaviours among 3- and 4-year-old children in urban and rural settings in low-income, middle-income and high-income countries: the SUNRISE study protocol", "authors": [{"family": "Okely", "given": "Tony", "initials": "T"}, {"family": "Reilly", "given": "John J", "initials": "JJ"}, {"family": "Tremblay", "given": "Mark S", "initials": "MS"}, {"family": "Kariippanon", "given": "Katharina E", "initials": "KE", "orcid": "0000-0003-4269-682X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cdb4f12289b34e8593ad5727870ef08c.json"}}, {"family": "Draper", "given": "Catherine E", "initials": "CE"}, {"family": "El Hamdouchi", "given": "Asmaa", "initials": "A"}, {"family": "Florindo", "given": "Alex A", "initials": "AA"}, {"family": "Green", "given": "Janette P", "initials": "JP"}, {"family": "Guan", "given": "Hongyan", "initials": "H"}, {"family": "Katzmarzyk", "given": "Peter T", "initials": "PT"}, {"family": "Lubree", "given": "Himangi", "initials": "H"}, {"family": "Pham", "given": "Bang Nguyen", "initials": "BN"}, {"family": "Suesse", "given": "Thomas", "initials": "T"}, {"family": "Willumsen", "given": "Juana", "initials": "J"}, {"family": "Basheer", "given": "Mohamed", "initials": "M"}, {"family": "Calleia", "given": "Rebecca", "initials": "R"}, {"family": "Chong", "given": "Kar Hau", "initials": "KH"}, {"family": "Cross", "given": "Penny L", "initials": "PL"}, {"family": "Nacher", "given": "Maria", "initials": "M"}, {"family": "Smeets", "given": "Laura", "initials": "L"}, {"family": "Taylor", "given": "Ellie", "initials": "E"}, {"family": "Abdeta", "given": "Chalchisa", "initials": "C"}, {"family": "Aguilar-Farias", "given": "Nicolas", "initials": "N"}, {"family": "Baig", "given": "Aqsa", "initials": "A"}, {"family": "Bayasgalan", "given": "Jambaldori", "initials": "J"}, {"family": "Chan", "given": "Cecilia H S", "initials": "CHS"}, {"family": "Chathurangana", "given": "P W Prasad", "initials": "PWP"}, {"family": "Chia", "given": "Michael", "initials": "M"}, {"family": "Ghofranipour", "given": "Fazlollah", "initials": "F"}, {"family": "Ha", "given": "Amy S", "initials": "AS"}, {"family": "Hossain", "given": "Mohammad Sorowar", "initials": "MS"}, {"family": "Janssen", "given": "Xanne", "initials": "X"}, {"family": "J\u00e1uregui", "given": "Alejandra", "initials": "A"}, {"family": "Katewongsa", "given": "Piyawat", "initials": "P"}, {"family": "Kim", "given": "Dong Hoon", "initials": "DH"}, {"family": "Kim", "given": "Thanh Van", "initials": "TV"}, {"family": "Koh", "given": "Denise", "initials": "D"}, {"family": "Kontsevaya", "given": "Anna", "initials": "A", "orcid": "0000-0003-2062-1536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c23c67bbbc043aea62ee98370a94ba8.json"}}, {"family": "Leyna", "given": "Germana H", "initials": "GH"}, {"family": "L\u00f6f", "given": "M", "initials": "M"}, {"family": "Munambah", "given": "Nyaradzai", "initials": "N"}, {"family": "Mwase-Vuma", "given": "Tawonga", "initials": "T"}, {"family": "Nusurupia", "given": "Jackline", "initials": "J"}, {"family": "Oluwayomi", "given": "Aoko", "initials": "A"}, {"family": "del Pozo-Cruz", "given": "Borja", "initials": "B"}, {"family": "del Pozo-Cruz", "given": "Jesus", "initials": "J"}, {"family": "Roos", "given": "Eva", "initials": "E"}, {"family": "Shirazi", "given": "Asima", "initials": "A"}, {"family": "Singh", "given": "Pragya", "initials": "P"}, {"family": "Staiano", "given": "Amanda", "initials": "A"}, {"family": "Suherman", "given": "Adang", "initials": "A"}, {"family": "Tanaka", "given": "Chiaki", "initials": "C"}, {"family": "Tang", "given": "Hong Kim", "initials": "HK"}, {"family": "Teo", "given": "Wei Peng", "initials": "WP"}, {"family": "Tiongco", "given": "Marites M", "initials": "MM"}, {"family": "Tladi", "given": "Dawn", "initials": "D"}, {"family": "Turab", "given": "Ali", "initials": "A"}, {"family": "Veldman", "given": "Sanne L C", "initials": "SLC"}, {"family": "Webster", "given": "E Kipling", "initials": "EK"}, {"family": "Wickramasinghe", "given": "Pujitha", "initials": "P"}, {"family": "Widyastari", "given": "Dyah Anantalia", "initials": "DA"}], "type": "journal-article", "published": "2021-10-00", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "10", "pages": "e049267"}, "abstract": null, "doi": "10.1136/bmjopen-2021-049267", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:33:09.365Z", "modified": "2022-02-17T09:46:28.556Z"}, {"entity": "publication", "iuid": "7e8ac1a37684451792822dcb03dc7c4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e8ac1a37684451792822dcb03dc7c4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e8ac1a37684451792822dcb03dc7c4c"}}, "title": "Characteristics and Outcomes of Over 300,000 Patients with COVID-19 and History of Cancer in the United States and Spain.", "authors": [{"family": "Roel", "given": "Elena", "initials": "E", "orcid": "0000-0002-1964-3546", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad1d9cc65d3242339540f938eeceafe1.json"}}, {"family": "Pistillo", "given": "Andrea", "initials": "A", "orcid": "0000-0002-4467-0220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/055156368b8845a0bfdc522a53cc1b0d.json"}}, {"family": "Recalde", "given": "Martina", "initials": "M", "orcid": "0000-0003-2256-618X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a41e082476aa464484b65418923ad81e.json"}}, {"family": "Sena", "given": "Anthony G", "initials": "AG", "orcid": "0000-0001-8630-5347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9202e069d9c24646b006b6abb640b541.json"}}, {"family": "Fern\u00e1ndez-Bertol\u00edn", "given": "Sergio", "initials": "S"}, {"family": "Arag\u00f3n", "given": "Maria", "initials": "M"}, {"family": "Puente", "given": "Diana", "initials": "D"}, {"family": "Ahmed", "given": "Waheed-Ul-Rahman", "initials": "WU", "orcid": "0000-0003-0880-0355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27d074e0c92342d299e693d12173356c.json"}}, {"family": "Alghoul", "given": "Heba", "initials": "H", "orcid": "0000-0001-8234-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e3deb1abdf54088a29dee7675a18697.json"}}, {"family": "Alser", "given": "Osaid", "initials": "O", "orcid": "0000-0001-6743-803X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c919eb8e21f74327b80f25eae0313eb6.json"}}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM", "orcid": "0000-0002-5630-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5162aab03bc04dafa809108461f18667.json"}}, {"family": "Areia", "given": "Carlos", "initials": "C", "orcid": "0000-0002-4668-7069", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7232f54be5df43f0b984d0117d88a054.json"}}, {"family": "Blacketer", "given": "Clair", "initials": "C", "orcid": "0000-0003-2570-2124", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a325a8031ace41ed905c1c64b22fc653.json"}}, {"family": "Carter", "given": "William", "initials": "W"}, {"family": "Casajust", "given": "Paula", "initials": "P", "orcid": "0000-0003-2733-5436", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8a3feb959bd461c8c4ad81fcd9dee8b.json"}}, {"family": "Culhane", "given": "Aedin C", "initials": "AC", "orcid": "0000-0002-1395-9734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11a2209eca25401e9870f7b75f66df67.json"}}, {"family": "Dawoud", "given": "Dalia", "initials": "D", "orcid": "0000-0002-2105-1937", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e25c9903cd364cd5a14a32554f63c9da.json"}}, {"family": "DeFalco", "given": "Frank", "initials": "F"}, {"family": "DuVall", "given": "Scott L", "initials": "SL", "orcid": "0000-0002-4898-3865", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd524264c46548cf861123d43d57151a.json"}}, {"family": "Falconer", "given": "Thomas", "initials": "T"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Gong", "given": "Mengchun", "initials": "M"}, {"family": "Hester", "given": "Laura", "initials": "L", "orcid": "0000-0002-4593-1293", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a77277f84d5e433b849001f3287ee330.json"}}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Tan", "given": "Eng Hooi", "initials": "EH", "orcid": "0000-0003-4470-2736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72566a67becb42cab02d274915d24737.json"}}, {"family": "Jeon", "given": "Hokyun", "initials": "H"}, {"family": "Jonnagaddala", "given": "Jitendra", "initials": "J", "orcid": "0000-0002-9912-2344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8403290b9ec43fe93b558de97d84559.json"}}, {"family": "Lai", "given": "Lana Y H", "initials": "LYH", "orcid": "0000-0002-0485-0956", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc15faacca7f4857b5c7babef24ffaf4.json"}}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Natarajan", "given": "Karthik", "initials": "K"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Ostropolets", "given": "Anna", "initials": "A", "orcid": "0000-0002-0847-6682", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f642e577d2445a3a7ce873b42d0c479.json"}}, {"family": "Posada", "given": "Jos\u00e9 D", "initials": "JD"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A", "orcid": "0000-0003-1202-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47f086bb6ccd49a2a5f11a32c06277c8.json"}}, {"family": "Reich", "given": "Christian G", "initials": "CG"}, {"family": "Rivera", "given": "Donna R", "initials": "DR", "orcid": "0000-0002-4565-4556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40627463ecc34b9896787a9a71e3dbad.json"}}, {"family": "Schilling", "given": "Lisa M", "initials": "LM", "orcid": "0000-0002-6878-189X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7888233862b04fce978bb44ece6ccb19.json"}}, {"family": "Soerjomataram", "given": "Isabelle", "initials": "I"}, {"family": "Shah", "given": "Karishma", "initials": "K", "orcid": "0000-0002-6219-1653", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d792a1c7704b4093a3835642181f0865.json"}}, {"family": "Shah", "given": "Nigam H", "initials": "NH", "orcid": "0000-0001-9385-7158", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4aca07eb2cd948c3b736c30cb3f3b6e6.json"}}, {"family": "Shen", "given": "Yang", "initials": "Y"}, {"family": "Spotniz", "given": "Matthew", "initials": "M"}, {"family": "Subbian", "given": "Vignesh", "initials": "V"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Trama", "given": "Annalisa", "initials": "A", "orcid": "0000-0001-8220-9833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b54a2d0430e4ab783fcc82d8c9f8786.json"}}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhang", "given": "Ying", "initials": "Y"}, {"family": "Ryan", "given": "Patrick B", "initials": "PB"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Kostka", "given": "Kristin", "initials": "K", "orcid": "0000-0003-2595-8736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9675cf1b775341f6a3521c7dde950262.json"}}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T", "orcid": "0000-0002-8274-0357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11fd8deb257445e7a93a0a3098b246df.json"}}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Cancer Epidemiol Biomarkers Prev", "issn": "1538-7755", "volume": "30", "issue": "10", "pages": "1884-1894", "issn-l": null}, "abstract": "We described the demographics, cancer subtypes, comorbidities, and outcomes of patients with a history of cancer and coronavirus disease 2019 (COVID-19). Second, we compared patients hospitalized with COVID-19 to patients diagnosed with COVID-19 and patients hospitalized with influenza.\n\nWe conducted a cohort study using eight routinely collected health care databases from Spain and the United States, standardized to the Observational Medical Outcome Partnership common data model. Three cohorts of patients with a history of cancer were included: (i) diagnosed with COVID-19, (ii) hospitalized with COVID-19, and (iii) hospitalized with influenza in 2017 to 2018. Patients were followed from index date to 30 days or death. We reported demographics, cancer subtypes, comorbidities, and 30-day outcomes.\n\nWe included 366,050 and 119,597 patients diagnosed and hospitalized with COVID-19, respectively. Prostate and breast cancers were the most frequent cancers (range: 5%-18% and 1%-14% in the diagnosed cohort, respectively). Hematologic malignancies were also frequent, with non-Hodgkin's lymphoma being among the five most common cancer subtypes in the diagnosed cohort. Overall, patients were aged above 65 years and had multiple comorbidities. Occurrence of death ranged from 2% to 14% and from 6% to 26% in the diagnosed and hospitalized COVID-19 cohorts, respectively. Patients hospitalized with influenza (n = 67,743) had a similar distribution of cancer subtypes, sex, age, and comorbidities but lower occurrence of adverse events.\n\nPatients with a history of cancer and COVID-19 had multiple comorbidities and a high occurrence of COVID-19-related events. Hematologic malignancies were frequent.\n\nThis study provides epidemiologic characteristics that can inform clinical care and etiologic studies.", "doi": "10.1158/1055-9965.EPI-21-0266", "pmid": "34272262", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8974356"}, {"db": "pii", "key": "1055-9965.EPI-21-0266"}], "notes": [], "created": "2023-01-13T09:52:18.710Z", "modified": "2023-06-19T15:34:44.126Z"}, {"entity": "publication", "iuid": "a8edb57968704d61b7823bc613afbe4e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8edb57968704d61b7823bc613afbe4e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8edb57968704d61b7823bc613afbe4e"}}, "title": "COVID19 Disease Map, a computational knowledge repository of virus-host interaction mechanisms.", "authors": [{"family": "Ostaszewski", "given": "Marek", "initials": "M", "orcid": "0000-0003-1473-370X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad3ed3c26f8a4e49aa8edb0bba8ecb19.json"}}, {"family": "Niarakis", "given": "Anna", "initials": "A", "orcid": "0000-0002-9687-7426", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b96190acb1dd484a83a74afc41fd3c8c.json"}}, {"family": "Mazein", "given": "Alexander", "initials": "A", "orcid": "0000-0001-7137-4171", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2efd5e320ebf44e3a1b8847088b7eae7.json"}}, {"family": "Kuperstein", "given": "Inna", "initials": "I", "orcid": "0000-0001-8086-8915", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43f6315d46434416b8183e06a91084f3.json"}}, {"family": "Phair", "given": "Robert", "initials": "R", "orcid": "0000-0001-7979-2386", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44c205f1ef1a496b8dbdce7fd42c15c0.json"}}, {"family": "Orta-Resendiz", "given": "Aurelio", "initials": "A", "orcid": "0000-0002-6632-883X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53d9ab13209746ada1c3ca163c6c4807.json"}}, {"family": "Singh", "given": "Vidisha", "initials": "V", "orcid": "0000-0002-3250-6669", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/289debcdb0ee477a8c5ea140bb982742.json"}}, {"family": "Aghamiri", "given": "Sara Sadat", "initials": "SS", "orcid": "0000-0003-4440-7059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a27c186dd609468cbe5fdaf53453c8ae.json"}}, {"family": "Acencio", "given": "Marcio Luis", "initials": "ML", "orcid": "0000-0002-8278-240X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7a8ea6189a64d088e7303ec2362fc53.json"}}, {"family": "Glaab", "given": "Enrico", "initials": "E", "orcid": "0000-0003-3977-7469", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ac2ddf4b2f24e89bc6181099aeaf422.json"}}, {"family": "Ruepp", "given": "Andreas", "initials": "A", "orcid": "0000-0003-1705-3515", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc9fc4ee13f04a3ead276fa82d4b6de3.json"}}, {"family": "Fobo", "given": "Gisela", "initials": "G"}, {"family": "Montrone", "given": "Corinna", "initials": "C"}, {"family": "Brauner", "given": "Barbara", "initials": "B"}, {"family": "Frishman", "given": "Goar", "initials": "G"}, {"family": "Monraz G\u00f3mez", "given": "Luis Crist\u00f3bal", "initials": "LC"}, {"family": "Somers", "given": "Julia", "initials": "J", "orcid": "0000-0001-9489-2246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b48974bc51204f63875b9efd092bc1bd.json"}}, {"family": "Hoch", "given": "Matti", "initials": "M", "orcid": "0000-0002-2486-0246", "researcher": {"href": 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"https://publications-covid19.scilifelab.se/researcher/568efa35a020457b90f3f313d004dd58.json"}}, {"family": "Ponce de Leon", "given": "Miguel", "initials": "M", "orcid": "0000-0002-7496-844X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9fe25b6b14ae4521a63c615fa6142075.json"}}, {"family": "Funahashi", "given": "Akira", "initials": "A", "orcid": "0000-0003-0605-239X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d17761419d74a31b088c3bd101c1df3.json"}}, {"family": "Hiki", "given": "Yusuke", "initials": "Y", "orcid": "0000-0001-6955-3867", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8977c92272dd4699873a2bc2ab5d8c86.json"}}, {"family": "Hiroi", "given": "Noriko", "initials": "N", "orcid": "0000-0002-0214-373X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4aff05ff5feb424f8884803732142a91.json"}}, {"family": "Yamada", "given": "Takahiro G", "initials": "TG", "orcid": "0000-0002-1665-1778", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bacf1beecd94f8b99cf8f4279660a56.json"}}, {"family": "Dr\u00e4ger", "given": "Andreas", "initials": "A", "orcid": "0000-0002-1240-5553", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/846ba169210444f2816b6b9ab616169e.json"}}, {"family": "Renz", "given": "Alina", "initials": "A", "orcid": "0000-0003-3851-9978", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6fec830968244a7bbceacd4a6de8e56c.json"}}, {"family": "Naveez", "given": "Muhammad", "initials": "M", "orcid": "0000-0003-2437-2055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dfe41d31a2ca4cdfb4ffdc9336313a03.json"}}, {"family": "Bocskei", "given": "Zsolt", "initials": "Z", "orcid": "0000-0002-6105-2504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39081a56066543189b92ebf3f8d461fa.json"}}, 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"https://publications-covid19.scilifelab.se/researcher/2b82bd1326364f20b99c31bc4c87c928.json"}}, {"family": "Pico", "given": "Alexander R", "initials": "AR", "orcid": "0000-0001-5706-2163", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f0c2f9e7ae342b091262f25e50074b6.json"}}, {"family": "Evelo", "given": "Chris T", "initials": "CT", "orcid": "0000-0002-5301-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2dd7e54b2c56497a834ee9e803ee76d5.json"}}, {"family": "Gillespie", "given": "Marc E", "initials": "ME", "orcid": "0000-0002-5766-1702", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9ccfe4704504a99873bd800e86e59be.json"}}, {"family": "Stein", "given": "Lincoln D", "initials": "LD", "orcid": "0000-0002-1983-4588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e7d7a39c24c40f99f00639a9fdab10c.json"}}, {"family": "Hermjakob", "given": "Henning", "initials": "H", "orcid": "0000-0001-8479-0262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89303e87266b44fbaf33a811713257cd.json"}}, {"family": "D'Eustachio", "given": "Peter", "initials": "P", "orcid": "0000-0002-5494-626X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53d33c1e054540b8b8730e913dbb282b.json"}}, {"family": "Saez-Rodriguez", "given": "Julio", "initials": "J", "orcid": "0000-0002-8552-8976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/95931a9232ee4e82b01252e9ab31e8cd.json"}}, {"family": "Dopazo", "given": "Joaquin", "initials": "J", "orcid": "0000-0003-3318-120X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7701cf5d39f4d6cb455cd27ace48bb0.json"}}, {"family": "Valencia", "given": "Alfonso", "initials": "A", "orcid": "0000-0002-8937-6789", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9877cbb9a124eb0b99b5e1d8cde4752.json"}}, {"family": "Kitano", "given": "Hiroaki", "initials": "H", "orcid": "0000-0002-3589-1953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e945269c001427b9cce60f288d8c3bc.json"}}, {"family": "Barillot", "given": "Emmanuel", "initials": "E", "orcid": "0000-0003-2724-2002", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/601bf39565aa494dbf347a8f6af6d9c9.json"}}, {"family": "Auffray", "given": "Charles", "initials": "C", "orcid": "0000-0003-2226-7411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/653a07414125471a991ac5733bc1cfea.json"}}, {"family": "Balling", "given": "Rudi", "initials": "R", "orcid": "0000-0003-2902-5650", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e72fef5ff024aa0bc2cd5bf02add22f.json"}}, {"family": "Schneider", "given": "Reinhard", "initials": "R", "orcid": "0000-0002-8278-1618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/16d96bb94cd34671aa3f30868e37d6c7.json"}}, {"family": "COVID-19 Disease Map Community", "given": "", "initials": ""}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Mol Syst Biol", "issn": "1744-4292", "volume": "17", "issue": "10", "pages": "e10387", "issn-l": "1744-4292"}, "abstract": "We need to effectively combine the knowledge from surging literature with complex datasets to propose mechanistic models of SARS-CoV-2 infection, improving data interpretation and predicting key targets of intervention. Here, we describe a large-scale community effort to build an open access, interoperable and computable repository of COVID-19 molecular mechanisms. The COVID-19 Disease Map (C19DMap) is a graphical, interactive representation of disease-relevant molecular mechanisms linking many knowledge sources. Notably, it is a computational resource for graph-based analyses and disease modelling. To this end, we established a framework of tools, platforms and guidelines necessary for a multifaceted community of biocurators, domain experts, bioinformaticians and computational biologists. The diagrams of the C19DMap, curated from the literature, are integrated with relevant interaction and text mining databases. We demonstrate the application of network analysis and modelling approaches by concrete examples to highlight new testable hypotheses. This framework helps to find signatures of SARS-CoV-2 predisposition, treatment response or prioritisation of drug candidates. Such an approach may help deal with new waves of COVID-19 or similar pandemics in the long-term perspective.", "doi": "10.15252/msb.202110387", "pmid": "34664389", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-21T04:54:54.498Z", "modified": "2021-10-21T04:54:57.857Z"}, {"entity": "publication", "iuid": "a2ac4ed89b574e36a58271d2411b0d88", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2ac4ed89b574e36a58271d2411b0d88.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2ac4ed89b574e36a58271d2411b0d88"}}, "title": "COVID-19 and handwashing: Implications for water use in Sub-Saharan Africa.", "authors": [{"family": "Amuakwa-Mensah", "given": "Franklin", "initials": "F"}, {"family": "Klege", "given": "Rebecca Afua", "initials": "RA"}, {"family": "Adom", "given": "Philip Kofi", "initials": "PK"}, {"family": "K\u00f6hlin", "given": "Gunnar", "initials": "G"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Water Resour Econ", "issn": "2212-4284", "volume": "36", "pages": "100189", "issn-l": null}, "abstract": "Because the main modes of transmission of the COVID-19 virus are respiration and contact, WHO recommends frequent washing of hands with soap under running water for at least 20 s. This article investigates how the level of concern about COVID-19 affects the likelihood of washing hands frequently in sub-Saharan Africa. We discuss the implication of the findings for water-scarce environment. The study makes use of a unique survey dataset from 12 sub-Saharan African countries collected in April 2020 (first round) and May 2020 (second round) and employs an extended ordered probit model with endogenous covariate. The results show that the level of concern about the spread of the virus increases the likelihood of washing hands with soap under running water for a minimum of 20 s at least five times a day. The increase in the probability of handwashing due to concern about COVID-19, ranges from 3% for Benin to 6.3% for South Africa. The results also show heterogeneous effects across gender- and age-groups, locality and various water sources. However, in Africa, the sustainability of the handwashing protocol could be threatened by the severe water scarcity that exists in the region. To sustain frequent handwashing, sub-Saharan Africa needs an effective strategy for water management and supply.", "doi": "10.1016/j.wre.2021.100189", "pmid": "34745865", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2212-4284(21)00013-X"}, {"db": "pmc", "key": "PMC8563594"}], "notes": [], "created": "2021-11-26T15:34:51.447Z", "modified": "2021-11-26T15:34:51.482Z"}, {"entity": "publication", "iuid": "eb5532c9c30840e7ae31b631e10eb2ac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb5532c9c30840e7ae31b631e10eb2ac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb5532c9c30840e7ae31b631e10eb2ac"}}, "title": "Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19.", "authors": [{"family": "Aamodt", "given": "Anne Hege", "initials": "AH", "orcid": "0000-0002-2824-2760", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b21211bae394fef867be93f162d8ef8.json"}}, {"family": "H\u00f8gest\u00f8l", "given": "Einar August", "initials": "EA", "orcid": "0000-0001-8446-2111", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be2ccda7a98243e78919d6e58629b5cf.json"}}, {"family": "Popperud", "given": "Trine Haug", "initials": "TH"}, {"family": "Holter", "given": "Jan Cato", "initials": "JC", "orcid": "0000-0003-1618-5022", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7b6512c252a422badaaa120ee2aa700.json"}}, {"family": "Dyrhol-Riise", "given": "Anne Ma", "initials": "AM", "orcid": "0000-0003-4009-4032", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/051b91855a064394a525b898992aa834.json"}}, {"family": "Tonby", "given": "Kristian", "initials": "K", "orcid": "0000-0002-8465-1315", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dee8c27f3f184a52aaf4b1a82c0efe0e.json"}}, {"family": "Stiksrud", "given": "Birgitte", "initials": "B", "orcid": "0000-0001-9679-8181", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd511102a315446cb0fcef7e1a5b4f7b.json"}}, {"family": "Quist-Paulsen", "given": "Else", "initials": "E", "orcid": "0000-0002-1633-5660", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93114d4a49524fb4af2479a8ec268365.json"}}, {"family": "Berge", "given": "Tone", "initials": "T", "orcid": "0000-0002-5297-2034", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bae2754b3324238a3d36933f0b2d001.json"}}, {"family": "Barratt-Due", "given": "Andreas", "initials": "A", "orcid": "0000-0001-5408-7162", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f6cdc11b90949d2b825b76eee88333b.json"}}, {"family": "Aukrust", "given": "P\u00e5l", "initials": "P", "orcid": "0000-0002-6509-6221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e946d8e631c46f6b9613c7f73755e6d.json"}}, {"family": "Heggelund", "given": "Lars", "initials": "L", "orcid": "0000-0002-1669-1032", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9befa124c647487d803e8dba68495821.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/351fab09f6e24b9f9e6695da83947cb6.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e314740b02c344d2b336a9410e28041e.json"}}, {"family": "Harbo", "given": "Hanne Flinstad", "initials": "HF", "orcid": "0000-0002-6047-0122", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90fa41f3df4b40df903efcacad11b947.json"}}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "J Neurol", "issn": "1432-1459", "volume": "268", "issue": "10", "pages": "3574-3583", "issn-l": null}, "abstract": "To test the hypotheses that blood biomarkers for nervous system injury, serum concentrations of neurofilament light chain protein (NfL) and glial fibrillary acidic protein (GFAp) can serve as biomarkers for disease severity in COVID-19 patients.\n\nForty-seven inpatients with confirmed COVID-19 had blood samples drawn on admission for assessing serum biomarkers of CNS injury by Single molecule array (Simoa), NfL and GFAp. Concentrations of NfL and GFAp were analyzed in relation to symptoms, clinical signs, inflammatory biomarkers and clinical outcomes. We used multivariate linear models to test for differences in biomarker concentrations in the subgroups, accounting for confounding effects.\n\nIn total, 21% (n = 10) of the patients were admitted to an intensive care unit, and the overall mortality rate was 13% (n = 6). Non-survivors had higher serum concentrations of NfL (p < 0.001) upon admission than patients who were discharged alive both in adjusted analyses (p = 2.6 \u00d7 10-7) and unadjusted analyses (p = 0.001). The concentrations of NfL in non-survivors increased over repeated measurements; whereas, the concentrations in survivors were stable. The GFAp concentration was also significantly higher in non-survivors than survivors (p = 0.02).\n\nIncreased concentrations of NfL and GFAp in COVID-19 patients on admission may indicate increased mortality risk. Measurement of blood biomarkers for nervous system injury can be useful to detect and monitor CNS injury in COVID-19.", "doi": "10.1007/s00415-021-10517-6", "pmid": "33743046", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7980743"}, {"db": "pii", "key": "10.1007/s00415-021-10517-6"}], "notes": [], "created": "2021-03-22T10:17:46.101Z", "modified": "2023-06-19T14:57:19.636Z"}, {"entity": "publication", "iuid": "c66d19afa22c45fd98d6bf059cb208d8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c66d19afa22c45fd98d6bf059cb208d8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c66d19afa22c45fd98d6bf059cb208d8"}}, "title": "Biomarkers for central nervous system injury in cerebrospinal fluid are elevated in COVID-19 and associated with neurological symptoms and disease severity.", "authors": [{"family": "Virhammar", "given": "Johan", "initials": "J", "orcid": "0000-0001-9901-2949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9db4ac69a3e8495ea8e71ae60042fa5c.json"}}, {"family": "N\u00e4\u00e4s", "given": "Anja", "initials": "A"}, {"family": "F\u00e4llmar", "given": "David", "initials": "D"}, {"family": "Cunningham", "given": "Janet L", "initials": "JL"}, {"family": "Klang", "given": "Andrea", "initials": "A"}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ"}, {"family": "Jackmann", "given": "Sven", "initials": "S"}, {"family": "Westman", "given": "Gabriel", "initials": "G"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Rostami", "given": "Elham", "initials": "E"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Eur J Neurol", "issn": "1468-1331", "issn-l": null, "volume": "28", "issue": "10", "pages": "3324-3331"}, "abstract": "Neurological symptoms have been frequently reported in hospitalized patients with coronavirus disease 2019 (COVID-19), and biomarkers of central nervous system (CNS) injury are reported to be increased in plasma but not extensively studied in cerebrospinal fluid (CSF). This study examined CSF for biomarkers of CNS injury and other pathology in relation to neurological symptoms and disease severity in patients with neurological manifestations of COVID-19.\n\nNineteen patients with neurological symptoms and mild to critical COVID-19 were prospectively included. Extensive analysis of CSF, including measurement of biomarkers of CNS injury (neurofilament light chain [NfL] protein, glial fibrillary acidic protein [GFAp], and total tau), was performed and compared to neurological features and disease severity.\n\nNeurological symptoms included altered mental status (42%), headache (42%), and central (21%) and peripheral weakness (32%). Two patients demonstrated minor pleocytosis, and four patients had increased immunoglobulin G levels in CSF. Neuronal autoantibody testing using commercial tests was negative in all patients. Increased CSF levels of NfL protein, total tau, and GFAp were seen in 63%, 37%, and 16% of patients, respectively. Increased NfL protein correlated with disease severity, time in intensive care, and level of consciousness. NfL protein in CSF was higher in patients with central neurological symptoms.\n\nAlthough limited by the small sample size, our data suggest that levels of NfL protein, GFAp, and total tau in CSF are commonly elevated in patients with COVID-19 with neurological symptoms. This is in contrast to the standard CSF workup where pathological findings are scarce. NfL protein, in particular, is associated with central neurological symptoms and disease severity.", "doi": "10.1111/ene.14703", "pmid": "33369818", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8518988"}], "notes": [], "created": "2021-01-07T13:15:08.321Z", "modified": "2021-12-12T18:06:16.091Z"}, {"entity": "publication", "iuid": "2b1f786eed0c4282b1e2f6ae144bf76d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b1f786eed0c4282b1e2f6ae144bf76d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b1f786eed0c4282b1e2f6ae144bf76d"}}, "title": "A longitudinal study on symptom duration and 60-day clinical course in non-hospitalised COVID-19 cases in Berlin, Germany, March to May, 2020.", "authors": [{"family": "Saad", "given": "Neil J", "initials": "NJ"}, {"family": "Moek", "given": "Felix", "initials": "F"}, {"family": "Steitz", "given": "Fabienne", "initials": "F"}, {"family": "Murajda", "given": "Lukas", "initials": "L"}, {"family": "B\u00e4rnighausen", "given": "Till", "initials": "T"}, {"family": "Zoller", "given": "Thomas", "initials": "T"}, {"family": "P\u00f6rtner", "given": "Kirsten", "initials": "K"}, {"family": "Muller", "given": "Nadine", "initials": "N"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "43", "issn-l": null}, "abstract": "BackgroundDetailed information on symptom duration and temporal course of patients with mild COVID-19 was scarce at the beginning of the COVID-19 pandemic.AimWe aimed to determine the longitudinal course of clinical symptoms in non-hospitalised COVID-19 patients in Berlin, Germany.MethodsBetween March and May 2020, 102 confirmed COVID-19 cases in home isolation notified in Berlin, Germany, were sampled using total population sampling. Data on 25 symptoms were collected during telephone consultations (a maximum of four consultations) with each patient. We collected information on prevalence and duration of symptoms for each day of the first 2 weeks after symptom onset and for day 30 and 60 after symptom onset.ResultsMedian age was 35 years (range 18-74), 57% (58/102) were female, and 37% (38/102) reported having comorbidities. During the first 2 weeks, most common symptoms were malaise (94%, 92/98), headache (71%, 70/98), and rhinitis (69%, 68/98). Malaise was present for a median of 11 days (IQR 7-14 days) with 35% (34/98) of cases still reporting malaise on day 14. Headache and muscle pain mostly occurred during the first week, whereas dysosmia and dysgeusia mostly occurred during the second week. Symptoms persisted in 41% (39/95) and 20% (18/88) of patients on day 30 and 60, respectively.ConclusionOur study shows that a significant proportion of non-hospitalised COVID-19 cases endured symptoms for at least 2 months. Further research is needed to assess the frequency of long-term adverse health effects in non-hospitalised COVID-19 patients.", "doi": "10.2807/1560-7917.ES.2021.26.43.2001757", "pmid": "34713798", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:51:46.148Z", "modified": "2021-11-01T19:51:46.163Z"}, {"entity": "publication", "iuid": "3ed4dababe18432292a120455da77843", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ed4dababe18432292a120455da77843.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ed4dababe18432292a120455da77843"}}, "title": "The Upper Respiratory Tract of Felids Is Highly Susceptible to SARS-CoV-2 Infection.", "authors": [{"family": "Kr\u00fcger", "given": "Nadine", "initials": "N", "orcid": "0000-0002-4413-8699", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/397f978cad79487e89676dc30b50f227.json"}}, {"family": "Rocha", "given": "Cheila", "initials": "C", "orcid": "0000-0002-0148-9405", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c49cd1df09cb49399d87e33722f400e8.json"}}, {"family": "Runft", "given": "Sandra", "initials": "S"}, {"family": "Kr\u00fcger", "given": "Johannes", "initials": "J"}, {"family": "F\u00e4rber", "given": "Iris", "initials": "I", "orcid": "0000-0002-3390-5880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61e578b4819a415d9db7daef5d2a8c55.json"}}, {"family": "Armando", "given": "Federico", "initials": "F"}, {"family": "Leitzen", "given": "Eva", "initials": "E", "orcid": "0000-0002-3818-9246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44e86d0862104a4aae31c94715ca130b.json"}}, {"family": "Brogden", "given": "Graham", "initials": "G", "orcid": "0000-0002-2306-7932", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3015adaef844c0bad26d535324e19d9.json"}}, {"family": "Gerold", "given": "Gisa", "initials": "G", "orcid": "0000-0002-1326-5038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39af3df98cf14f96baa155798617841b.json"}}, {"family": "P\u00f6hlmann", "given": "Stefan", "initials": "S", "orcid": "0000-0001-6086-9136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03c63bbe69c949748dc5ecd3ec438492.json"}}, {"family": "Hoffmann", "given": "Markus", "initials": "M", "orcid": "0000-0003-4603-7696", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b40ee42e4354ca99c33a2633bbbaed4.json"}}, {"family": "Baumg\u00e4rtner", "given": "Wolfgang", "initials": "W"}], "type": "journal article", "published": "2021-09-30", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "22", "issue": "19", "issn-l": null}, "abstract": "Natural or experimental infection of domestic cats and virus transmission from humans to captive predatory cats suggest that felids are highly susceptible to SARS-CoV-2 infection. However, it is unclear which cells and compartments of the respiratory tract are infected. To address this question, primary cell cultures derived from the nose, trachea, and lungs of cat and lion were inoculated with SARS-CoV-2. Strong viral replication was observed for nasal mucosa explants and tracheal air-liquid interface cultures, whereas replication in lung slices was less efficient. Infection was mainly restricted to epithelial cells and did not cause major pathological changes. Detection of high ACE2 levels in the nose and trachea but not lung further suggests that susceptibility of feline tissues to SARS-CoV-2 correlates with ACE2 expression. Collectively, this study demonstrates that SARS-CoV-2 can efficiently replicate in the feline upper respiratory tract ex vivo and thus highlights the risk of SARS-CoV-2 spillover from humans to felids.", "doi": "10.3390/ijms221910636", "pmid": "34638978", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijms221910636"}, {"db": "pmc", "key": "PMC8508926"}], "notes": [], "created": "2021-10-21T05:28:18.673Z", "modified": "2021-10-21T05:28:50.620Z"}, {"entity": "publication", "iuid": "d6dbde36b7d041d087bdd5e48bddf97a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d6dbde36b7d041d087bdd5e48bddf97a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d6dbde36b7d041d087bdd5e48bddf97a"}}, "title": "Global Prevalence of Adaptive and Prolonged Infections\u2019 Mutations in the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein", "authors": [{"family": "Lennerstrand", "given": "Johan", "initials": "J"}, {"family": "Palanisamy", "given": "Navaneethan", "initials": "N", "orcid": "0000-0003-0369-2316", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e92f0f2edcb4c8eaa66f55c59490717.json"}}], "type": "journal-article", "published": "2021-09-30", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "10", "pages": "1974", "issn-l": "1999-4915"}, "abstract": null, "doi": "10.3390/v13101974", "pmid": null, "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:30:11.056Z", "modified": "2021-10-26T18:30:11.115Z"}, {"entity": "publication", "iuid": "e6ae64a793f84661ac387675c53ac24e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6ae64a793f84661ac387675c53ac24e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6ae64a793f84661ac387675c53ac24e"}}, "title": "An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responses.", "authors": [{"family": "Mangsbo", "given": "Sara M", "initials": "SM", "orcid": "0000-0002-1355-2678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cf494629d8a4f9584ada4be16dff66b.json"}}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Laur\u00e9n", "given": "Ida", "initials": "I"}, {"family": "Lindsay", "given": "Robin", "initials": "R", "orcid": "0000-0001-7867-8653", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf1f32f9550141fb8c4ebbb0cbe09e51.json"}}, {"family": "Jernbom Falk", "given": "August", "initials": "A", "orcid": "0000-0002-7773-1851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40d944d7fa964f4292f10012356a2730.json"}}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Lord", "given": "Martin", "initials": "M", "orcid": "0000-0002-3238-3187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ddcd91137ed4f8c88b2beb2db340081.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "D\u00f6nnes", "given": "Pierre", "initials": "P"}, {"family": "Christoffersson", "given": "Gustaf", "initials": "G"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "evaluation study", "published": "2021-09-30", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "9", "pages": "e0258041"}, "abstract": "Numerous assays evaluating serological and cellular responses have been developed to characterize immune responses against SARS-CoV-2. Serological assays are both cost- and time-effective compared to cellular assays, but cellular immune responses may provide a diagnostic value to determine previous SARS-CoV-2 infection in seronegative individuals. However, potential cross-reactive T cell responses stemming from prior encounters with human coronaviruses (HCoVs) may affect assay specificity. In this study, we evaluated the specificity and sensitivity of a SARS-CoV-2 IFN-\u03b3 Release Assay (IGRA) based on the FluoroSpot method employing commercially available SARS-CoV-2-specific peptide pools, as well as an in-house designed SARS-CoV-2 peptide pool restricted to 5 amino acid stretches or less aligning with endemic HCoVs. Blood samples were obtained from healthcare workers (HCW) 5-6 months post SARS-CoV-2 spike (S) IgG and nucleocapsid (N) IgG dual seroconversion (n = 187) and HCW who had been S IgG and N IgG dual seronegative at repeated occasions, including the current sampling time point (n = 102). In addition, samples were obtained 4 to 5 months post infection from 55 polymerase chain reaction (PCR)-confirmed COVID-19 patients. Assay specificity and sensitivity were calculated with serology as a reference standard for HCW. The in-house generated peptide pool displayed a specificity of 96.1%, while the commercially available peptide pools displayed specificities of 80.4% and 85.3%, respectively. Sensitivity was higher in a cohort of previously hospitalized COVID-19 patients (96.4% and 84.0% for the commercially available peptide pools and 92.7% for the in-house generated peptide pool) compared to the HCW cohort (92.0% and 66.8% for the commercially available peptide pools and 76.0% for the in-house generated peptide pool). Based on these findings, the individual diagnostic value of T cell immune responses against SARS-CoV-2 currently appears to be limited but remain an important research tool ahead.", "doi": "10.1371/journal.pone.0258041", "pmid": "34591918", "labels": {"Category: Imaging": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-19070"}, {"db": "pmc", "key": "PMC8483319"}], "notes": [], "created": "2021-11-18T15:12:02.239Z", "modified": "2021-11-19T10:47:39.135Z"}, {"entity": "publication", "iuid": "6f7064f617d945d68996fc33dbc10b00", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f7064f617d945d68996fc33dbc10b00.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f7064f617d945d68996fc33dbc10b00"}}, "title": "SARS-CoV-2 integral membrane proteins shape the serological responses of COVID-19 patients.", "authors": [{"family": "Martin", "given": "Sophie", "initials": "S"}, {"family": "Heslan", "given": "Christopher", "initials": "C"}, {"family": "J\u00e9gou", "given": "Gw\u00e9na\u00eble", "initials": "G"}, {"family": "Eriksson", "given": "Leif A", "initials": "LA"}, {"family": "Le Gallo", "given": "Matthieu", "initials": "M"}, {"family": "Thibault", "given": "Vincent", "initials": "V"}, {"family": "Chevet", "given": "Eric", "initials": "E"}, {"family": "Godey", "given": "Florence", "initials": "F"}, {"family": "Avril", "given": "Tony", "initials": "T"}], "type": "journal article", "published": "2021-09-29", "journal": {"title": "iScience", "issn": "2589-0042", "pages": "103185", "issn-l": "2589-0042"}, "abstract": "SARS-CoV-2 pandemic has elicited a unique mobilization of the scientific community to develop efficient tools to understand and combat infection. Like other coronavirae, SARS-CoV-2 hijacks host cell secretory machinery to produce viral proteins that compose the nascent virions; including Spike (S), Envelope (E) and Membrane (M) proteins, the most exposed transmembrane proteins to the host immune system. As antibody response is part of the anti-viral immune arsenal, we investigate the immunogenic potential of S, E and M using a human cell-based system to mimic membrane insertion and N-glycosylation. Both S and M elicit specific Ig production in SARS-CoV-2 patients. Patients with moderate and severe diseases exhibit elevated Ig responses. Finally, reduced Ig binding was observed with Spike G614 compared to D614 variant. Altogether, our assay points towards an unexpected immune response against M and represents a powerful tool to test humoral responses against actively evolving SARS-CoV-2 variants and vaccine effectiveness.", "doi": "10.1016/j.isci.2021.103185", "pmid": "34604721", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(21)01153-6"}, {"db": "pmc", "key": "PMC8479324"}, {"db": "URL", "key": "https://data.mendeley.com/datasets/69tvkst9ct/1", "description": "clinical and raw data related to serological assay"}], "notes": [], "created": "2021-10-11T17:56:55.960Z", "modified": "2021-10-15T07:54:32.174Z"}, {"entity": "publication", "iuid": "b2e64a7af9894313b4e54453e26ffae7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b2e64a7af9894313b4e54453e26ffae7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b2e64a7af9894313b4e54453e26ffae7"}}, "title": "High level of protection against COVID-19 after two doses of BNT162b2 vaccine in the working age population \u2013 first results from a cohort study in Southern Sweden", "authors": [{"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J", "orcid": "0000-0003-1883-2000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e88fdca336ae41c891f0a46e2481b67f.json"}}, {"family": "Inghammar", "given": "Malin", "initials": "M", "orcid": "0000-0003-2995-1312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4ab710428614cccb2a537ecab31d0a0.json"}}, {"family": "Moghaddassi", "given": "Mahnaz", "initials": "M", "orcid": "0000-0002-0844-4736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a219bde5ba8a4f3f8655ada08d749885.json"}}, {"family": "Rasmussen", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1588-5473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c760e8d21ae441ba236f86e6185d392.json"}}, {"family": "Malmqvist", "given": "Ulf", "initials": "U"}, {"family": "Kahn", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-5566-6350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42eda71f3775400599febc10a4e7359c.json"}}], "type": "journal-article", "published": "2021-09-29", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4235", "issn-l": null, "volume": null, "issue": null, "pages": "1-6"}, "abstract": "Vaccine effectiveness against COVID-19 needs to be assessed in diverse real-world population settings.\n\nA cohort study of 805,741 residents in Sk\u00e5ne county, Southern Sweden, aged 18-64 years, of whom 26,587 received at least one dose of the BNT162b2 vaccine. Incidence rates of COVID-19 were estimated in sex- and age-adjusted analysis and stratified in two-week periods with substantial community spread of the disease.\n\nThe estimated vaccine effectiveness in preventing infection \u22657 days after second dose was 86% (95% CI 72-94%) but only 42% (95% CI 14-63%) \u226514 days after a single dose. No difference in vaccine effectiveness was observed between females and males. Having a prior positive test was associated with 91% (95% CI 85-94%) effectiveness against new infection among the unvaccinated.\n\nA satisfactory effectiveness of BNT162b2 after the second dose was suggested, but with possibly substantially lower effect before the second dose.", "doi": "10.1080/23744235.2021.1982144", "pmid": "34586934", "labels": {"Category: Biochemistry": null, "Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null, "Funder: VR": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC8500302"}], "notes": [], "created": "2021-10-11T18:09:45.592Z", "modified": "2021-11-29T06:13:18.964Z"}, {"entity": "publication", "iuid": "80e9261113314fb7856ca4ae73f8dc27", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/80e9261113314fb7856ca4ae73f8dc27.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/80e9261113314fb7856ca4ae73f8dc27"}}, "title": "Solidarity and polarisation regarding COVID-19 and related risks - A thematic analysis of comments from an international survey.", "authors": [{"family": "Stjernsw\u00e4rd", "given": "Sigrid", "initials": "S"}, {"family": "Glasdam", "given": "Stinne", "initials": "S"}], "type": "journal article", "published": "2021-09-28", "journal": {"title": "Soc Sci Humanit Open", "issn": "2590-2911", "volume": "4", "issue": "1", "pages": "100211", "issn-l": null}, "abstract": "COVID-19 represents a risk to people's life and societies in their current shapes and functions, with institutionalised responses redefining everyday life. Crises in society can induce fear and tensions that can unite and divide people, inducing acts of solidarity and polarisation. The study explored articulations of solidarity and polarisation in relation to the COVID-19 pandemic and related risks. A Foucault-inspired thematic analysis was pursued on qualitative data from an international survey about COVID-19 and social media. The analysis resulted in four themes illustrating articulations of solidarity and polarisation related to the COVID-19 pandemic. The analysis showed solidarity and polarisation as each other's premise and contradiction. Socialisation into a 'new normal' was characterised by the balance between solidarity and polarisation as well as aspirations to enhance future solidarity. The study illustrated that social media functioned as social technology for control and manipulation towards social normalisation. However, it was also used to voice attempts to rectify (or overthrow) the dominant medico-political discourse and norms with own preferences, opinions and a functioning daily life. In short, the articulations and social media uses could be interpreted as expressions of power and counter-power.", "doi": "10.1016/j.ssaho.2021.100211", "pmid": "34604736", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2590-2911(21)00107-8"}, {"db": "pmc", "key": "PMC8479510"}], "notes": [], "created": "2021-10-11T17:56:21.609Z", "modified": "2021-10-11T17:56:21.646Z"}, {"entity": "publication", "iuid": "321676cd0e76407a9091ffc38c3adc4e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/321676cd0e76407a9091ffc38c3adc4e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/321676cd0e76407a9091ffc38c3adc4e"}}, "title": "Risk for SARS-CoV-2 infection in healthcare workers outside hospitals: A real-life immuno-virological study during the first wave of the COVID-19 epidemic.", "authors": [{"family": "Fr\u00f6berg", "given": "Maria", "initials": "M"}, {"family": "Hassan", "given": "Sadaf Sakina", "initials": "SS"}, {"family": "Pimenoff", "given": "Ville N", "initials": "VN"}, {"family": "Akterin", "given": "Susanne", "initials": "S"}, {"family": "Conneryd Lundgren", "given": "Kalle", "initials": "K"}, {"family": "Elfstr\u00f6m", "given": "K Miriam", "initials": "KM"}, {"family": "Dillner", "given": "Joakim", "initials": "J", "orcid": "0000-0001-8588-6506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bbb8b0ca5dc648e0b80c1de224b26c69.json"}}], "type": "journal article", "published": "2021-09-28", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "9", "pages": "e0257854", "issn-l": "1932-6203"}, "abstract": "Most COVID-19 related infections and deaths may occur in healthcare outside hospitals. Here we explored SARS-CoV-2 infections among healthcare workers (HCWs) in this setting.\n\nAll healthcare providers in Stockholm, Sweden were asked to recruit HCWs at work for a study of past or present SARS-CoV-2 infections among HCWs. Study participants This study reports the results from 839 HCWs, mostly employees of primary care centers, sampled in June 2020.\n\nSARS-CoV-2 seropositivity was found among 12% (100/839) of HCWs, ranging from 0% to 29% between care units. Seropositivity decreased by age and was highest among HCWs <40 years of age. Within this age group there was 19% (23/120) seropositivity among women and 11% (15/138) among men (p<0.02). Current infection, as measured using PCR, was found in only 1% and the typical testing pattern of pre-symptomatic potential \"superspreaders\" found in only 2/839 subjects.\n\nPrevious SARS-CoV-2 infections were common among younger HCWs in this setting. Pre-symptomatic infection was uncommon, in line with the strong variability in SARS-CoV-2 exposure between units. Prioritizing infection prevention and control including sufficient and adequate personal protective equipment, and vaccination for all HCWs are important to prevent nosocomial infections and infections as occupational injuries during an ongoing pandemic.", "doi": "10.1371/journal.pone.0257854", "pmid": "34582483", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-17200"}, {"db": "pmc", "key": "PMC8478233"}], "notes": [], "created": "2021-10-11T18:07:24.488Z", "modified": "2021-10-11T18:07:24.511Z"}, {"entity": "publication", "iuid": "b63a0c526c9045eb9f4dddb326b2f5f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b63a0c526c9045eb9f4dddb326b2f5f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b63a0c526c9045eb9f4dddb326b2f5f2"}}, "title": "Post-Traumatic Stress Disorder in Chinese Teachers during COVID-19 Pandemic: Roles of Fear of COVID-19, Nomophobia, and Psychological Distress.", "authors": [{"family": "Kukreti", "given": "Shikha", "initials": "S", "orcid": "0000-0002-8370-3988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d0daa4b90a164aaa8acfc4f1cebb7fd3.json"}}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK", "orcid": "0000-0003-0530-8138", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d442447b551649d8a5372c6bf0075c91.json"}}, {"family": "Strong", "given": "Carol", "initials": "C"}, {"family": "Chen", "given": "I-Hua", "initials": "I"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Ko", "given": "Nai-Ying", "initials": "N"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Chen", "given": "Yu-Pin", "initials": "Y"}, {"family": "Kuo", "given": "Yi-Jie", "initials": "Y"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-09-28", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "issn-l": null, "volume": "9", "issue": "10", "pages": null}, "abstract": "There are limited data concerning the prevalence of post-traumatic stress disorder (PTSD) among teachers. Therefore, the present study estimated the prevalence of PTSD among mainland Chinese teachers during the COVID-19 pandemic and to construct a model with mediation and moderation effects to explain the PTSD. Data collection was conducted in schools in the Jiangxi province between October and November 2020 among k-12 schoolteachers. An online survey, including five different psychometric scales, was used to collect data. All participants were assessed for PTSD using the Chinese version of the PTSD Checklist for DSM-5 (PCL-5). Hayes' PROCESS Model 8 was used to examine the potential factors explaining a higher PTSD scores. A total of 2603 teachers from k-12 schools participated. With the cutoff score at 31, the prevalence of PTSD was 12.3% but decreased to 1.0% when the cutoff score was at 49. Nomophobia moderated the effects of Fear of COVID-19 Scale on PTSD. The findings suggest that fear of COVID-19 among teachers leads to PTSD via psychological distress, highlighting the moderating effect of nomophobia in this association. Based on the study's findings, psychological interventions and educational training are needed to reduce fear among teachers at higher risk of developing PTSD.", "doi": "10.3390/healthcare9101288", "pmid": "34682968", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "healthcare9101288"}], "notes": [], "created": "2021-10-26T18:17:05.359Z", "modified": "2022-02-17T09:44:49.441Z"}, {"entity": "publication", "iuid": "18ed2ce5f25849da929c9e365ae4ec05", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18ed2ce5f25849da929c9e365ae4ec05.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18ed2ce5f25849da929c9e365ae4ec05"}}, "title": "A Retrospective Cross-Sectional Study Assessing Self-Reported Adverse Events following Immunization (AEFI) of the COVID-19 Vaccine in Bangladesh", "authors": [{"family": "Sultana", "given": "Arifa", "initials": "A", "orcid": "0000-0002-5855-8731", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b70e8f78af140dcb43d8c1ecf01232f.json"}}, {"family": "Shahriar", "given": "Saimon", "initials": "S", "orcid": "0000-0003-1460-3104", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f11efd633e6460a89dc1737e21c2fec.json"}}, {"family": "Tahsin", "given": "Md Rafat", "initials": "MR"}, {"family": "Mim", "given": "Sabiha Rahman", "initials": "SR"}, {"family": "Fatema", "given": "Kazi Rubiya", "initials": "KR", "orcid": "0000-0002-8368-0798", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f98d252b78e643d48f24a19d85c94d65.json"}}, {"family": "Saha", "given": "Ananya", "initials": "A"}, {"family": "Yesmin", "given": "Fahmida", "initials": "F"}, {"family": "Bahar", "given": "Nasiba Binte", "initials": "NB", "orcid": "0000-0002-5981-3220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3407484c9fc419eaccb9eff656148cc.json"}}, {"family": "Samodder", "given": "Mithun", "initials": "M", "orcid": "0000-0001-6057-7838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09d49d33289245208488f07cd60cc1c4.json"}}, {"family": "Mamun", "given": "Md Ariful Haque", "initials": "MAH", "orcid": "0000-0002-9123-5272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9c66bede129447b95970d7679c0dbce.json"}}, {"family": "Aknur Rahman", "given": "Md", "initials": "M"}, {"family": "Ferdousy", "given": "Sonia", "initials": "S"}, {"family": "Akter", "given": "Tahmina", "initials": "T"}, {"family": "Aktar", "given": "Fahima", "initials": "F"}, {"family": "Kuddus", "given": "Md Ruhul", "initials": "MR", "orcid": "0000-0002-7038-3399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6d42cef0bfa4239be0b59e947691ad2.json"}}, {"family": "Rahman", "given": "Md Mustafizur", "initials": "MM", "orcid": "0000-0001-8585-263X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/854727a42e374690931b6200ef95ac32.json"}}, {"family": "Sarker", "given": "Md Moklesur Rahman", "initials": "MMR", "orcid": "0000-0001-9795-0608", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86b27674f7f34e5993d6d26b752860c2.json"}}, {"family": "B\u00fcy\u00fcker", "given": "Sultan Mehtap", "initials": "SM"}, {"family": "Chowdhury", "given": "Jakir Ahmed", "initials": "JA"}, {"family": "Chowdhury", "given": "Abu Asad", "initials": "AA"}, {"family": "Kabir", "given": "Shaila", "initials": "S"}, {"family": "Hossain", "given": "Md Akter", "initials": "MA"}, {"family": "Amran", "given": "Md Shah", "initials": "MS"}], "type": "journal-article", "published": "2021-09-28", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "9", "issue": "10", "pages": "1090", "issn-l": null}, "abstract": null, "doi": "10.3390/vaccines9101090", "pmid": null, "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:29:44.988Z", "modified": "2021-10-26T18:29:45.283Z"}, {"entity": "publication", "iuid": "752e3e4deaa8429fa08ad1282d83045c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/752e3e4deaa8429fa08ad1282d83045c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/752e3e4deaa8429fa08ad1282d83045c"}}, "title": "The untold story of the COVID-19 pandemic: perceptions and views towards social stigma and bullying in the shadow of COVID-19 illness in Jordan.", "authors": [{"family": "Akour", "given": "Amal", "initials": "A", "orcid": "0000-0002-2789-8514", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7afcf3838a0e4150af12424aabdc69ed.json"}}, {"family": "AlMuhaissen", "given": "Suha A", "initials": "SA"}, {"family": "Nusair", "given": "Mohammad B", "initials": "MB"}, {"family": "Al-Tammemi", "given": "Ala'a B", "initials": "AB"}, {"family": "Mahmoud", "given": "Nouf N", "initials": "NN"}, {"family": "Jalouqa", "given": "Sarah", "initials": "S"}, {"family": "Alrawashdeh", "given": "Maissa N", "initials": "MN"}], "type": "journal article", "published": "2021-09-27", "journal": {"title": "SN Soc Sci", "issn": "2662-9283", "volume": "1", "issue": "9", "pages": "240", "issn-l": null}, "abstract": "Stigmatization towards COVID-19 patients can lead to negative outcomes like social exclusion and bullying, and it may hinder the willingness of people to undergo testing. This study aimed to measure and explore the perception of stigmatization and bullying towards COVID-19 patients in Jordan. This was a web-based cross-sectional survey. Participants were recruited from social media platforms employing a snowball convenience sampling. The perception of bullying, beliefs regarding social consequences of infection, views on measures towards violators of patients' privacy, and how to reduce the stigma were assessed by self-reported measures. 397 participants returned completed questionnaires. The majority of respondents believed that COVID-19 patients in Jordan are getting bullied (n = 255, 64.3%) and over 80% believed that people enjoy sharing identities, or news about COVID-19 patients. Although most respondents had adequate knowledge regarding transmission/prevention of COVID-19, they believed that all or some of the COVID-19 patients practiced something wrong to get infected (n = 358, 90.2%). Moreover, 86.9% of respondents reported that people in Jordan were crossing their lines with bullying behaviors towards COVID-19 patients. However, these negative views would not discourage most respondents to get tested and follow the government's instructions if they or any of their acquaintances were suspected to be infected. Our study sheds the light on a high degree of stigma and bullying of COVID-19 patients during the early stage of the pandemic in Jordan. Hence, there is a need to develop and implement effective anti-stigma/anti-bullying campaigns that refute the misperception, raise public knowledge about COVID-19, and spread encouraging messages.", "doi": "10.1007/s43545-021-00252-0", "pmid": "34693341", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "252"}, {"db": "pmc", "key": "PMC8475478"}], "notes": [], "created": "2021-10-26T18:24:07.111Z", "modified": "2021-10-26T18:24:19.356Z"}, {"entity": "publication", "iuid": "7dadb54b658943c599dfcd20763423e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7dadb54b658943c599dfcd20763423e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7dadb54b658943c599dfcd20763423e7"}}, "title": "Effects of the COVID-19 Health Crisis on Sports Practice, Life Quality, and Emotional Status in Spanish High-Performance Athletes.", "authors": [{"family": "Conde", "given": "Elena", "initials": "E"}, {"family": "Mart\u00ednez-Aranda", "given": "Luis Manuel", "initials": "LM"}, {"family": "Sanz", "given": "Gema", "initials": "G"}, {"family": "L\u00f3pez de Subijana", "given": "Cristina", "initials": "C"}, {"family": "S\u00e1nchez-Pato", "given": "Antonio", "initials": "A"}, {"family": "D\u00edaz-Aroca", "given": "\u00c1lvaro", "initials": "\u00c1"}, {"family": "Leiva-Arcas", "given": "Alejandro", "initials": "A"}, {"family": "Garc\u00eda-Roca", "given": "Juan Alfonso", "initials": "JA"}, {"family": "Ramis", "given": "Yago", "initials": "Y"}, {"family": "Torregrossa", "given": "Miquel", "initials": "M"}], "type": "journal article", "published": "2021-09-27", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "12", "issue": null, "pages": "736499"}, "abstract": "Spain is one of the many countries highly affected by the COVID-19 crisis, establishing very restrictive measures with a complete lockdown for more than 3 months. This situation forced the complete closure of sport practice and national or international competitions, leading to a negative impact on physical and psychological health of high-performance athletes. Therefore, the objectives of this study were (a) to determine the effects of the COVID-19 health crisis on Spanish high-performance athletes in terms of sports practice, life quality, and emotional state and (b) to identify the profile with the greatest difficulties during and after the lockdown. A sample of 130 high-performance athletes aged between 18 and 34 years (67 women and 63 men) participated in this study (83.1% achieved a medal in National-International elite competitions; 86.9% were considered student-athletes). Measures included socio-demographic data through a 5-dimension ad hoc survey: physical activity and exercise using an adapted version from the International Physical Activity Questionnaire (IPAQ); health status and limitations using an adapted version of SF-12 Health Questionnaire; Perceived stress (Short-PSS); and Mood States (29-item POMS). All participants have shown a significant decrease pre-post-lockdown in both health and performance perception, especially in women, individual athletes, medalists, and student-athletes. Strong limitations of training, attention, and motivation as well as a moderate negative emotional state during lockdown were reported, in women, individual athletes, medalists, and student-athletes. Even with an improved emotional state and energy level in the post-lockdown period, moderate-to-high stress scores were reported by women and medalists. Our findings highlight the importance of paying attention to the physical and psychological health of elite athletes on three profiles: team athletes (due to social distance), student-athletes (dual-career issues), and women athletes (prevalence of implicit gender inequalities in sport).", "doi": "10.3389/fpsyg.2021.736499", "pmid": "34646217", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8503513"}], "notes": [], "created": "2021-10-21T05:06:54.003Z", "modified": "2022-02-17T09:41:26.123Z"}, {"entity": "publication", "iuid": "d097b7933e1548aa946c8a6664f08eef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d097b7933e1548aa946c8a6664f08eef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d097b7933e1548aa946c8a6664f08eef"}}, "title": "Current international trends in the treatment of multiple sclerosis in children-Impact of the COVID-19 pandemic.", "authors": [{"family": "Sandesj\u00f6", "given": "Fredrik", "initials": "F"}, {"family": "Wassmer", "given": "Evangeline", "initials": "E"}, {"family": "Deiva", "given": "Kumaran", "initials": "K"}, {"family": "Amato", "given": "Maria Pia", "initials": "MP"}, {"family": "Chitnis", "given": "Tanuja", "initials": "T"}, {"family": "Hemingway", "given": "Cheryl", "initials": "C"}, {"family": "Krupp", "given": "Lauren", "initials": "L"}, {"family": "Pohl", "given": "Daniela", "initials": "D"}, {"family": "Rostasy", "given": "Kevin", "initials": "K"}, {"family": "Waubant", "given": "Emanuelle", "initials": "E"}, {"family": "Banwell", "given": "Brenda", "initials": "B"}, {"family": "Wickstr\u00f6m", "given": "Ronny", "initials": "R"}], "type": "journal article", "published": "2021-09-27", "journal": {"title": "Mult Scler Relat Disord", "issn": "2211-0356", "volume": "56", "pages": "103277", "issn-l": null}, "abstract": "Only recently has the first disease-modifying therapy been approved for children with multiple sclerosis (MS) and practice patterns including substantial off-label use have evolved. Understanding attitudes towards treatment of paediatric MS and whether this has changed due to the ongoing COVID-19 pandemic is vital to guide future therapeutic trials and for developing guidelines that reflect practice.\n\nWe performed an online survey within the International Paediatric Multiple Sclerosis Study Group between July and September 2020. The survey was sent to 130 members from 25 countries and consisted of five sections: demographic data, treatment, disease modifying therapies and COVID-19, outcome and three patient cases.\n\nThe survey was completed by 66 members (51%), both paediatric neurologists and adult neurologists. Fingolimod and \u03b2-interferons were the most frequently used disease-modifying therapies, especially among paediatric neurologists. Almost a third (31%) of respondents had altered their prescribing practice due to COVID-19, in particular at the beginning of the pandemic.\n\nThe survey results indicate a tendency of moving from the traditional escalation therapy starting with injectables towards an early start with newer, highly effective disease modifying therapies. The COVID-19 pandemic only slightly affected prescribing patterns and treatment choices in paediatric MS.", "doi": "10.1016/j.msard.2021.103277", "pmid": "34624643", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2211-0348(21)00544-7"}], "notes": [], "created": "2021-10-10T15:03:50.886Z", "modified": "2021-10-10T15:03:50.911Z"}, {"entity": "publication", "iuid": "65abebe3c4d04d1f875bdfda78b65758", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65abebe3c4d04d1f875bdfda78b65758.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65abebe3c4d04d1f875bdfda78b65758"}}, "title": "Increased Risks of Death and Hospitalization in Influenza/Pneumonia and Sepsis for Individuals Affected by Psychotic Disorders, Bipolar Disorders, and Single Manic Episodes: A Retrospective Cross-Sectional Study.", "authors": [{"family": "Nilsson", "given": "Niklas Harry", "initials": "NH"}, {"family": "Bendix", "given": "Marie", "initials": "M"}, {"family": "\u00d6hlund", "given": "Louise", "initials": "L"}, {"family": "Widerstr\u00f6m", "given": "Micael", "initials": "M", "orcid": "0000-0002-1483-4255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ad36fa63a334e3b91499527bb6d5659.json"}}, {"family": "Werneke", "given": "Ursula", "initials": "U", "orcid": "0000-0002-5023-3254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eed3b002ddb4cbba141cbfdc8d3f032.json"}}, {"family": "Maripuu", "given": "Martin", "initials": "M", "orcid": "0000-0001-7868-8894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f85873e152d421eba74e23054d0ff1e.json"}}], "type": "journal article", "published": "2021-09-26", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "10", "issue": "19", "pages": null}, "abstract": "Individuals with severe mental disorders (SMDs) such as psychotic disorders, bipolar disorders, and single manic episodes have increased mortality associated with COVID-19 infection. We set up a population-based study to examine whether individuals with SMD also had a higher risk of hospitalization and death from other infectious conditions. Anonymized and summarized data from multiple Swedish patient registers covering the entire Swedish population were supplied by the Swedish National Board of Health and Welfare. The frequencies of hospitalizations and deaths associated with influenza/pneumonia and sepsis in individuals with SMD were compared with the rest of the population during 2018-2019. Possible contributing comorbidities were also examined, of which diabetes, cardiovascular disease, chronic lung disease, and hypertension were chosen. A total of 7,780,727 individuals were included in the study; 97,034 (1.2%) cases with SMD and 7,683,693 (98.8%) controls. Individuals with SMD had increased risk of death associated with influenza/pneumonia (OR = 2.06, 95% CI [1.87-2.27]) and sepsis (OR = 1.61, 95% CI [1.38-1.89]). They also had an increased risk of hospitalization associated with influenza/pneumonia (OR = 2.12, 95% CI [2.03-2.20]) and sepsis (OR = 1.89, 95% CI [1.75-2.03]). Our results identify a need for further evaluation of whether these individuals should be included in prioritized risk groups for vaccination against infectious diseases other than COVID-19.", "doi": "10.3390/jcm10194411", "pmid": "34640430", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "jcm10194411"}, {"db": "pmc", "key": "PMC8509221"}], "notes": [], "created": "2021-10-21T05:09:08.038Z", "modified": "2022-02-17T09:42:49.284Z"}, {"entity": "publication", "iuid": "2d573fe40a9649649525c7d6641a5a59", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d573fe40a9649649525c7d6641a5a59.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d573fe40a9649649525c7d6641a5a59"}}, "title": "Covid-19 in patients with chronic lymphocytic leukemia: clinical outcome and B- and T-cell immunity during 13 months in consecutive patients.", "authors": [{"family": "Blixt", "given": "Lisa", "initials": "L"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "Johansson", "given": "Hemming", "initials": "H"}, {"family": "Kjellander", "given": "Christian", "initials": "C"}, {"family": "Mravinacova", "given": "Sara", "initials": "S", "orcid": "0000-0003-1848-910X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fc9538cb055479494e5595ed901546a.json"}}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Palma", "given": "Marzia", "initials": "M", "orcid": "0000-0003-4287-3179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a4c445a486340619a33ab910011d64a.json"}}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE", "orcid": "0000-0003-1907-3392", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26a3bf24bd044fbda8ffa0c89974bdfe.json"}}, {"family": "Stromberg", "given": "Olga", "initials": "O"}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M", "orcid": "0000-0002-3793-4064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4bc179656eb442f9ac9dc72c8c6841d.json"}}, {"family": "Zain", "given": "Rula", "initials": "R", "orcid": "0000-0001-8327-846X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5a5815a733a4677b9f38403738a8741.json"}}, {"family": "Hansson", "given": "Lotta", "initials": "L", "orcid": "0000-0001-6614-5737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96cb28e556c643b99c77ce78754738af.json"}}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A", "orcid": "0000-0001-6489-4865", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d91b9eda8764ffea7f7926029c806d2.json"}}], "type": "journal article", "published": "2021-09-25", "journal": {"title": "Leukemia", "issn": "1476-5551", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "We studied clinical and immunological outcome of Covid-19 in consecutive CLL patients from a well-defined area during month 1-13 of the pandemic. Sixty patients (median age 71 y, range 43-97) were identified. Median CIRS was eight (4-20). Patients had indolent CLL (n = 38), had completed (n = 12) or ongoing therapy (n = 10). Forty-six patients (77%) were hospitalized due to severe Covid-19 and 11 were admitted to ICU. Severe Covid-19 was equally distributed across subgroups irrespective of age, gender, BMI, CLL status except CIRS (p < 0.05). Fourteen patients (23%) died; age \u226575 y was the only significant risk factor (p < 0.05, multivariate analysis with limited power). Comparing month 1-6 vs 7-13 of the pandemic, deaths were numerically reduced from 32% to 18%, ICU admission from 37% to 15% whereas hospitalizations remained frequent (86% vs 71%). Seroconversion occurred in 33/40 patients (82%) and anti-SARS-CoV-2 antibodies were detectable at six and 12 months in 17/22 and 8/11 patients, respectively. Most (13/17) had neutralizing antibodies and 19/28 had antibodies in saliva. SARS-CoV-2-specific T-cells (ELISpot) were detected in 14/17 patients. Covid-19 continued to result in high admission even among consecutive and young early- stage CLL patients. A robust and durable B and/or T cell immunity was observed in most convalescents.", "doi": "10.1038/s41375-021-01424-w", "pmid": "34564699", "labels": {"Research Area: High-throughput and high-content serology": null, "Funder: VR": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41375-021-01424-w"}, {"db": "pmc", "key": "PMC8475381"}], "notes": [], "created": "2021-11-18T15:53:16.064Z", "modified": "2021-12-12T18:10:28.317Z"}, {"entity": "publication", "iuid": "8828134f28fd4f4ca34b1436ec27ca9d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8828134f28fd4f4ca34b1436ec27ca9d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8828134f28fd4f4ca34b1436ec27ca9d"}}, "title": "Meaning-Making Coping Methods among Bereaved Parents: A Pilot Survey Study in Sweden.", "authors": [{"family": "Ahmadi", "given": "Fereshteh", "initials": "F", "orcid": "0000-0002-8823-6434", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f4f676633f24637b135c494dcb33cc9.json"}}, {"family": "Zandi", "given": "Saeid", "initials": "S", "orcid": "0000-0003-1272-7170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a941295613dc468e8282c9f8f157a4b6.json"}}], "type": "journal article", "published": "2021-09-24", "journal": {"title": "Behav Sci (Basel)", "issn": "2076-328X", "issn-l": null, "volume": "11", "issue": "10", "pages": null}, "abstract": "The death of a child may result in traumatizing forms of grief, and meaning-making coping with loss seems to be important in prevention of intense psychosocial problems among bereaved parents. The aim of this quantitative pilot study was to discover the divergent meaning-making coping methods used by bereaved parents in Sweden. In doing so, 162 respondents were selected using a convenience sampling method, and they responded to the modified version of RCOPE. The study revealed that the strategies talking to others about their feelings, pondering the meaning of life alone, and being in nature for greater emotional affiliation, i.e., what we call secular existential coping methods, have been the most used meaning-making coping methods among Swedish mourning parents. While explaining the results, we considered the respondents' cultural background and speculated about the potential influence of cultural teachings and elements in the selection of ways of coping with bereavement. Further, we compared the results obtained with those of the two other Swedish studies conducted among people coping with cancer and COVID-19 to further discuss the impact of culture on coping with illness, loss, grief, and crisis. The study supports the idea that culture plays an essential role in the choice of coping methods.", "doi": "10.3390/bs11100131", "pmid": "34677224", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bs11100131"}], "notes": [], "created": "2021-10-26T18:13:36.323Z", "modified": "2022-02-17T09:43:16.000Z"}, {"entity": "publication", "iuid": "b72a917223fa44d19c89cc86317f9892", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b72a917223fa44d19c89cc86317f9892.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b72a917223fa44d19c89cc86317f9892"}}, "title": "Identification of Unique Peptides for SARS-CoV-2 Diagnostics and Vaccine Development by an In Silico Proteomics Approach", "authors": [{"family": "Kesarwani", "given": "Veerbhan", "initials": "V"}, {"family": "Gupta", "given": "Rupal", "initials": "R"}, {"family": "Vetukuri", "given": "Ramesh Raju", "initials": "RR"}, {"family": "Kushwaha", "given": "Sandeep Kumar", "initials": "SK"}, {"family": "Gandhi", "given": "Sonu", "initials": "S"}], "type": "journal-article", "published": "2021-09-24", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "12", "issue": null, "pages": null}, "abstract": null, "doi": "10.3389/fimmu.2021.725240", "pmid": "34630400", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:50:30.496Z", "modified": "2021-11-29T06:11:19.925Z"}, {"entity": "publication", "iuid": "4ec7caedc3b24a29bc302f9d20e3bb70", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ec7caedc3b24a29bc302f9d20e3bb70.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ec7caedc3b24a29bc302f9d20e3bb70"}}, "title": "Power and sample size calculation for the win odds test: application to an ordinal endpoint in COVID-19 trials.", "authors": [{"family": "Gasparyan", "given": "Samvel B", "initials": "SB", "orcid": "0000-0002-4797-2208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fe0aea6b8d940a4aa97beac64753452.json"}}, {"family": "Kowalewski", "given": "Elaine K", "initials": "EK", "orcid": "0000-0002-7915-877X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0c063ae9205470c9803add8044303bc.json"}}, {"family": "Folkvaljon", "given": "Folke", "initials": "F"}, {"family": "Bengtsson", "given": "Olof", "initials": "O"}, {"family": "Buenconsejo", "given": "Joan", "initials": "J", "orcid": "0000-0003-4514-2208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90cef2fa64d0486681f64332929d92cf.json"}}, {"family": "Adler", "given": "John", "initials": "J"}, {"family": "Koch", "given": "Gary G", "initials": "GG"}], "type": "journal article", "published": "2021-09-23", "journal": {"title": "J Biopharm Stat", "issn": "1520-5711", "pages": "1-23", "issn-l": null}, "abstract": "The win odds is a distribution-free method of comparing locations of distributions of two independent random variables. Introduced as a method for analyzing hierarchical composite endpoints, it is well suited to be used in the analysis of ordinal scale endpoints in COVID-19 clinical trials. For a single outcome, we provide power and sample size calculation formulas for the win odds test. We also provide an implementation of the win odds analysis method for a single ordinal outcome in a commonly used statistical software to make the win odds analysis fully reproducible.", "doi": "10.1080/10543406.2021.1968893", "pmid": "34551682", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-27T05:15:02.850Z", "modified": "2021-10-27T05:15:03.000Z"}, {"entity": "publication", "iuid": "7dc1fbdac9ae42de922320b7cfc08524", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7dc1fbdac9ae42de922320b7cfc08524.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7dc1fbdac9ae42de922320b7cfc08524"}}, "title": "Comparing Fear of COVID-19 and Preventive COVID-19 Infection Behaviors Between Iranian and Taiwanese Older People: Early Reaction May Be a Key", "authors": [{"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Liu", "given": "Chieh hsiu", "initials": "Ch"}, {"family": "Hou", "given": "Wen Li", "initials": "WL"}, {"family": "Chen", "given": "Yu Pin", "initials": "YP"}, {"family": "Li", "given": "Yueh Ping", "initials": "YP"}, {"family": "Kuo", "given": "Yi Jie", "initials": "YJ"}, {"family": "Lin", "given": "Chung Ying", "initials": "CY"}, {"family": "Scarf", "given": "Damian", "initials": "D"}], "type": "journal-article", "published": "2021-09-23", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2021.740333", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:49:06.339Z", "modified": "2021-10-11T17:49:06.356Z"}, {"entity": "publication", "iuid": "1b450365873f4738bbced961b479b7cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b450365873f4738bbced961b479b7cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b450365873f4738bbced961b479b7cc"}}, "title": "SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism.", "authors": [{"family": "Jing", "given": "Yukai", "initials": "Y"}, {"family": "Luo", "given": "Li", "initials": "L"}, {"family": "Chen", "given": "Ying", "initials": "Y"}, {"family": "Westerberg", "given": "Lisa S", "initials": "LS"}, {"family": "Zhou", "given": "Peng", "initials": "P", "orcid": "0000-0001-9863-4201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8bf90702b7734b368503bc0926b23738.json"}}, {"family": "Xu", "given": "Zhiping", "initials": "Z"}, {"family": "Herrada", "given": "Andr\u00e9s A", "initials": "AA"}, {"family": "Park", "given": "Chan-Sik", "initials": "CS"}, {"family": "Kubo", "given": "Masato", "initials": "M"}, {"family": "Mei", "given": "Heng", "initials": "H"}, {"family": "Hu", "given": "Yu", "initials": "Y", "orcid": "0000-0002-2815-4568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0af90511a1494949bec5b0e595720c28.json"}}, {"family": "Lee", "given": "Pamela Pui-Wah", "initials": "PP"}, {"family": "Zheng", "given": "Bing", "initials": "B"}, {"family": "Sui", "given": "Zhiwei", "initials": "Z"}, {"family": "Xiao", "given": "Wei", "initials": "W"}, {"family": "Gong", "given": "Quan", "initials": "Q"}, {"family": "Lu", "given": "Zhongxin", "initials": "Z"}, {"family": "Liu", "given": "Chaohong", "initials": "C"}], "type": "journal article", "published": "2021-09-22", "journal": {"title": "Signal Transduct Target Ther", "issn": "2059-3635", "volume": "6", "issue": "1", "pages": "345", "issn-l": null}, "abstract": "The SARS-CoV-2 infection causes severe immune disruption. However, it is unclear if disrupted immune regulation still exists and pertains in recovered COVID-19 patients. In our study, we have characterized the immune phenotype of B cells from 15 recovered COVID-19 patients, and found that healthy controls and recovered patients had similar B-cell populations before and after BCR stimulation, but the frequencies of PBC in patients were significantly increased when compared to healthy controls before stimulation. However, the percentage of unswitched memory B cells was decreased in recovered patients but not changed in healthy controls upon BCR stimulation. Interestingly, we found that CD19 expression was significantly reduced in almost all the B-cell subsets in recovered patients. Moreover, the BCR signaling and early B-cell response were disrupted upon BCR stimulation. Mechanistically, we found that the reduced CD19 expression was caused by the dysregulation of cell metabolism. In conclusion, we found that SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism, which may provide a new intervention target to cure COVID-19.", "doi": "10.1038/s41392-021-00749-3", "pmid": "34552055", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41392-021-00749-3"}, {"db": "pmc", "key": "PMC8456405"}], "notes": [], "created": "2021-10-27T05:16:20.906Z", "modified": "2021-10-27T05:16:21.016Z"}, {"entity": "publication", "iuid": "dce6ed2b4e614c32b631d3857edb6053", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dce6ed2b4e614c32b631d3857edb6053.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dce6ed2b4e614c32b631d3857edb6053"}}, "title": "Making wise choices about low-value health care in the COVID-19 pandemic.", "authors": [{"family": "Clarke", "given": "Mike", "initials": "M"}, {"family": "Born", "given": "Karen", "initials": "K"}, {"family": "Johansson", "given": "Minna", "initials": "M"}, {"family": "J\u00f8rgensen", "given": "Karsten Juhl", "initials": "KJ"}, {"family": "Levinson", "given": "Wendy", "initials": "W"}, {"family": "Madrid", "given": "Eva", "initials": "E"}, {"family": "Meng", "given": "Dina Muscat", "initials": "DM"}, {"family": "Franco", "given": "Juan Victor Ariel", "initials": "JVA"}], "type": "editorial", "published": "2021-09-22", "journal": {"title": "Cochrane Database Syst Rev", "issn": "1469-493X", "volume": "9", "pages": "ED000153", "issn-l": null}, "abstract": null, "doi": "10.1002/14651858.ED000153", "pmid": "34549804", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-10-27T05:13:29.740Z", "modified": "2021-10-27T05:14:17.038Z"}, {"entity": "publication", "iuid": "69390533297940e28f31380bf9b161d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69390533297940e28f31380bf9b161d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69390533297940e28f31380bf9b161d9"}}, "title": "Do conspiracy theory and mistrust undermine people's intention to receive the COVID-19 vaccine in Austria?", "authors": [{"family": "Knobel", "given": "Phil", "initials": "P", "orcid": "0000-0003-2297-1193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bdf58f509c3e4e3b946fdd515d3cc9a8.json"}}, {"family": "Zhao", "given": "Xiang", "initials": "X", "orcid": "0000-0003-1054-9462", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad1f806684e54bc5986a15525c0a7c2d.json"}}, {"family": "White", "given": "Katherine M", "initials": "KM", "orcid": "0000-0002-0345-4724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e0eb1e8900e42c5ab75076f6b169218.json"}}], "type": "journal article", "published": "2021-09-22", "journal": {"title": "J Community Psychol", "issn": "1520-6629", "issn-l": null}, "abstract": "Conspiracy theories flourish during the coronavirus disease 2019 (COVID-19) pandemic especially regarding vaccinations. As the vaccination reluctancy in Austria is high, it is important to understand the antecedents of vaccination intention at the preapproval stage of the vaccination process. An online survey was conducted in August 2020 in Austria with 217 primarily younger, female, educated participants. A two-step cluster analysis resulted in a sceptics cluster with a clear antivaccination tendency along with a right-wing political position, lower trust in general vaccines and lower education levels and the reference cluster. A considerable percentage of participants reported their reluctancy to have a COVID-19 vaccine. Although vaccination intention can be explained by attitude and subjective norm, this decision-making process is undermined by underlying factors such as conspiracy ideation and political position. Policy makers and health interventionists should take political background into consideration in efforts to increase vaccine compliance.", "doi": "10.1002/jcop.22714", "pmid": "34551127", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-27T05:15:41.457Z", "modified": "2021-10-27T05:15:41.597Z"}, {"entity": "publication", "iuid": "b830017933024b4faf78792c42b2bb8a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b830017933024b4faf78792c42b2bb8a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b830017933024b4faf78792c42b2bb8a"}}, "title": "The Impact of COVID-19 on Sleep in Autistic Adults: Longitudinal Comparisons pre and During Lockdown.", "authors": [{"family": "Halstead", "given": "Elizabeth J", "initials": "EJ"}, {"family": "Sullivan", "given": "Emma C", "initials": "EC"}, {"family": "Dimitriou", "given": "Dagmara", "initials": "D"}], "type": "journal article", "published": "2021-09-21", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "708339", "issn-l": "1664-0640"}, "abstract": "Background: The longer-term impact of the pandemic on autistic adults' sleep are yet to be revealed, with studies concentrating on sleep in autistic children or mental health outcomes and coping strategies of autistic adults. Given the prevalence of sleep problems experienced by autistic adults and the changes in routine that have occurred as a result of COVID-19 societal restrictions, this study assessed the impact of the COVID-19 pandemic on sleep problems via a longitudinal subjective assessment method. Methods: Sleep data were gathered at three time points from 95 autistic adults, namely prior to the pandemic, at the start of COVID-19 and several months into COVID-19 to obtain a rich longitudinal dataset ascertaining how/if sleep patterns have changed in autistic adults over these several months. Results: In comparison to pre-lockdown, several sleep components were shown to improve during the lockdown. These improvements included reduced sleep latency (time taken to fall asleep), longer sleep duration, improved sleep efficiency, improved sleep quality, as well as improved daytime functioning. Pre-sleep cognitive arousal scores were found to decrease compared to pre-lockdown, meaning cognitive arousal improved. Approximately 65% of participants reported that they felt their sleep had been impacted since COVID-19 since Time 1, with the most common reasons reported as waking up exhausted (36.92%), not being able to get to sleep (33.85%), waking up in the night (29.23%), having a disrupted sleep pattern (27.69%), and nightmares (18.46%). Conclusions: Improvements in sleep may be related to societal changes (e.g., working from home) during the pandemic. Some of these changes are arguably beneficial for autistic adults in creating a more autism-inclusive society, for example telehealth opportunities for care. Further exploration of the associations between mental health and sleep are warranted.", "doi": "10.3389/fpsyt.2021.708339", "pmid": "34621194", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8490657"}], "notes": [], "created": "2021-10-10T15:08:30.601Z", "modified": "2021-10-10T15:08:30.611Z"}, {"entity": "publication", "iuid": "ef4b77c12ed44ed1a35fa7936352285c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef4b77c12ed44ed1a35fa7936352285c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef4b77c12ed44ed1a35fa7936352285c"}}, "title": "Priority Setting and Equity in COVID-19 Pandemic Plans: A Comparative Analysis of eighteen African Countries.", "authors": [{"family": "Kapiriri", "given": "Lydia", "initials": "L", "orcid": "0000-0002-1237-6369", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec392c3ae33d40f096e713eaa6a2be11.json"}}, {"family": "Kiwanuka", "given": "Suzanne", "initials": "S"}, {"family": "Biemba", "given": "Godfrey", "initials": "G"}, {"family": "Velez", "given": "Claudia", "initials": "C"}, {"family": "Razavi", "given": "S Donya", "initials": "SD"}, {"family": "Abelson", "given": "Julia", "initials": "J"}, {"family": "Essue", "given": "Beverly", "initials": "B"}, {"family": "Danis", "given": "Marion", "initials": "M"}, {"family": "Goold", "given": "Susan", "initials": "S"}, {"family": "Noorulhuda", "given": "Mariam", "initials": "M"}, {"family": "Nouvet", "given": "Elysee", "initials": "E"}, {"family": "Sandman", "given": "Lars", "initials": "L"}, {"family": "Williams", "given": "Ieystn", "initials": "I"}], "type": "journal article", "published": "2021-09-21", "journal": {"title": "Health Policy Plan", "issn": "1460-2237", "issn-l": null}, "abstract": "Priority setting represents an even bigger challenge during public health emergencies than routine times. This is because such emergencies compete with routine programs for the available health resources, strain health systems, and shift health care attention and resources towards containing the spread of the epidemic and treating those that fall seriously ill. This paper is part of a larger global study the aim of which is to evaluate the degree to which National COVID-19 preparedness and response plans incorporated priority setting concepts. IT and provides important insights into what and how priority decisions were made in a context of a pandemic. Specifically, with a focus on a sample of 18 African countries' pandemic plans, the paper aims to: (i) Explore the degree to which the documented priority setting processes adhere to established quality indicators of effective priority setting and (ii) To examine if there is a relationship between the number of quality indicators present in the pandemic plans and the country's economic context, health system and prior experiences with disease outbreaks. All the reviewed plans contained some aspects of expected priority setting processes but none of the national plans addressed all quality parameters. Most of the parameters were mentioned by less than 10 of the 18 country plans reviewed, and several plans identified one or two aspects of fair priority setting processes. Very few plans identified equity as a criterion for priority setting. Since the parameters are relevant to the quality of priority setting that is implemented during public health emergencies, and that most of the countries have pre-existing pandemic plans; it would be advisable that for the future (if not already happening) countries consider priority setting as a critical part of their routine health emergency and disease outbreak plans. Such an approach would ensure that priority setting is integral to pandemic planning, response, and recovery.", "doi": "10.1093/heapol/czab113", "pmid": "34545395", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6373138"}, {"db": "pmc", "key": "PMC8500007"}], "notes": [], "created": "2021-10-27T05:11:43.795Z", "modified": "2021-10-27T05:11:43.870Z"}, {"entity": "publication", "iuid": "610e095b5ab7410aaf936ca232bbc206", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/610e095b5ab7410aaf936ca232bbc206.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/610e095b5ab7410aaf936ca232bbc206"}}, "title": "Match-Fixing Causing Harm to Athletes on a COVID-19-Influenced Gambling Market: A Call for Research During the Pandemic and Beyond.", "authors": [{"family": "H\u00e5kansson", "given": "A", "initials": "A"}, {"family": "J\u00f6nsson", "given": "C", "initials": "C"}, {"family": "Kentt\u00e4", "given": "G", "initials": "G"}], "type": "journal article", "published": "2021-09-21", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "712300", "issn-l": "1664-1078"}, "abstract": "Match-fixing, although not a new problem, has received growing attention during the COVID-19 pandemic, which has been reported in the media to have increased the risk of match-fixing events. Gambling is a well-documented addictive behavior, and gambling-related fraud, match-fixing, is a challenge to the world of sports. Most research on match-fixing has a judicial or institutional perspective, and few studies focus on its individual consequences. Nevertheless, athletes may be at particular risk of mental health consequences from the exposure to or involvement in match-fixing. The COVID-19 crisis puts a spotlight on match-fixing, as the world of competitive sports shut down or changed substantially due to pandemic-related restrictions. We call for research addressing individual mental health and psycho-social correlates of match-fixing, and their integration into research addressing problem gambling, related to the pandemic and beyond.", "doi": "10.3389/fpsyg.2021.712300", "pmid": "34621216", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8490709"}], "notes": [], "created": "2021-10-10T15:08:15.461Z", "modified": "2021-10-10T15:08:15.471Z"}, {"entity": "publication", "iuid": "dfbabb7d946f4e988f6f3f48695c7edb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dfbabb7d946f4e988f6f3f48695c7edb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dfbabb7d946f4e988f6f3f48695c7edb"}}, "title": "Using informative features in machine learning based method for COVID-19 drug repurposing.", "authors": [{"family": "Aghdam", "given": "Rosa", "initials": "R", "orcid": "0000-0001-9045-9592", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/947e042b69f44191bb9aa48ca17314bb.json"}}, {"family": "Habibi", "given": "Mahnaz", "initials": "M"}, {"family": "Taheri", "given": "Golnaz", "initials": "G"}], "type": "journal article", "published": "2021-09-20", "journal": {"title": "J Cheminform", "issn": "1758-2946", "volume": "13", "issue": "1", "pages": "70", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) is caused by a novel virus named Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). This virus induced a large number of deaths and millions of confirmed cases worldwide, creating a serious danger to public health. However, there are no specific therapies or drugs available for COVID-19 treatment. While new drug discovery is a long process, repurposing available drugs for COVID-19 can help recognize treatments with known clinical profiles. Computational drug repurposing methods can reduce the cost, time, and risk of drug toxicity. In this work, we build a graph as a COVID-19 related biological network. This network is related to virus targets or their associated biological processes. We select essential proteins in the constructed biological network that lead to a major disruption in the network. Our method from these essential proteins chooses 93 proteins related to COVID-19 pathology. Then, we propose multiple informative features based on drug-target and protein-protein interaction information. Through these informative features, we find five appropriate clusters of drugs that contain some candidates as potential COVID-19 treatments. To evaluate our results, we provide statistical and clinical evidence for our candidate drugs. From our proposed candidate drugs, 80% of them were studied in other studies and clinical trials.", "doi": "10.1186/s13321-021-00553-9", "pmid": "34544500", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13321-021-00553-9"}, {"db": "pmc", "key": "PMC8451172"}], "notes": [], "created": "2021-10-10T15:37:29.486Z", "modified": "2021-11-19T10:49:54.346Z"}, {"entity": "publication", "iuid": "a245e60b78414c3b85feb1892b29e055", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a245e60b78414c3b85feb1892b29e055.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a245e60b78414c3b85feb1892b29e055"}}, "title": "The Association Between Financial Hardship and Mental Health Difficulties Among Adult Wage Earners During the COVID-19 Pandemic in Bangladesh: Findings From a Cross-Sectional Analysis.", "authors": [{"family": "Sultana", "given": "Mst Sadia", "initials": "MS"}, {"family": "Khan", "given": "Abid Hasan", "initials": "AH"}, {"family": "Hossain", "given": "Sahadat", "initials": "S"}, {"family": "Islam", "given": "Tauhidul", "initials": "T"}, {"family": "Hasan", "given": "M Tasdik", "initials": "MT"}, {"family": "Ahmed", "given": "Helal Uddin", "initials": "HU"}, {"family": "Li", "given": "Zezhi", "initials": "Z"}, {"family": "Khan", "given": "Jahangir A M", "initials": "JAM"}], "type": "journal article", "published": "2021-09-20", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "635884", "issn-l": "1664-0640"}, "abstract": "Background: The ongoing COVID-19 pandemic has created several challenges including financial burdens that may result in mental health conditions. This study was undertaken to gauge mental health difficulties during the COVID-19 pandemic and gain an insight into wage earners' mental health. Method: This cross-sectional study was conducted through an online survey. A t total of 707 individual Bangladeshi wage earners were enrolled between 20 and 30 May 2020. The questionnaire had sections on sociodemographic information, COVID-19 related questions, PHQ-9 and GAD-7 scales. STATA version 14.1 program was used to carry out all the analyses. Results: The study revealed that 58.6 and 55.9% of the respondents had moderate to severe anxiety and depressive symptoms, respectively. The total monthly income was <30,000 BDT (353.73USD) and displayed increased odds of suffering from depressive symptoms (OR = 4.12; 95% CI: 2.68-6.34) and anxiety (OR = 3.31; 95% CI: 2.17-5.03). Participants who did not receive salary income, had no income source during the pandemic, had financial problems, and inadequate food supply and were more likely to suffer from anxiety and depressive symptoms (p \u2264 0.01). Perceiving the upcoming financial crisis as a stressor was a potential risk factor for anxiety (OR = 1.91; 95% CI:1.32-2.77) and depressive symptoms (OR = 1.50; 95% CI:1.04-2.16). Limitations: The online survey method used in this study limits the generalizability of the findings and self-reported answers might include selection and social desirability bias as a community-based survey was not possible during the pandemic. Conclusion: Wage earners in a low resource setting like Bangladesh require mental health attention and financial consideration to deal with mental health difficulties.", "doi": "10.3389/fpsyt.2021.635884", "pmid": "34616314", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8488168"}], "notes": [], "created": "2021-10-10T15:25:30.166Z", "modified": "2021-10-10T15:25:30.177Z"}, {"entity": "publication", "iuid": "7b93bc8d2d3443a98a676c5352936599", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b93bc8d2d3443a98a676c5352936599.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b93bc8d2d3443a98a676c5352936599"}}, "title": "Sickness Presenteeism Among the Swedish Self-Employed During the Covid-19 Pandemic.", "authors": [{"family": "Vinberg", "given": "Stig", "initials": "S"}, {"family": "Landstad", "given": "Bodil J", "initials": "BJ"}, {"family": "Tjulin", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Nordenmark", "given": "Mikael", "initials": "M"}], "type": "journal article", "published": "2021-09-20", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "723036", "issn-l": "1664-1078"}, "abstract": "The present study analyzed the impact of business operations, work and family circumstances, and well-being on the risk of sickness presenteeism for Swedish self-employed workers during the Covid-19 pandemic. It is of great importance to investigate the impact of the pandemic on the self-employed and their enterprises because they are seen as key drivers of economic growth and constitute an expanding group in many countries. Data were obtained from 845 self-employed workers by a web-based survey including questions about background information, work and family circumstances, well-being, sickness presenteeism, and questions about the pandemic. Results were that around 40% of the self-employed introduced new products, processes, and marketing methods, and just over 50% attempted to get new customers during the pandemic. Nearly half of the self-employed people reported that they lost contracts, and 22% judged the risk of bankruptcy to be quite or highly likely. Regression analyses showed that the more the self-employed reported impact on business indicators, increased work hours, a higher level of work-family conflict, and a lower level of mental well-being, the higher the risk of sickness presenteeism. The most common reasons given by the participants for sickness presenteeism during the pandemic were \"nobody else can carry out my responsibilities,\" \"I can't afford to take sick leave\" and \"I enjoy my work.\" Conclusions are that a critical event such as the pandemic probably adds to an already high workload for the self-employed. Impact on business operations such as developing new products/services and marketing, risk of bankruptcy and increased work hours seems to be important factors for explaining sickness presenteeism among the self-employed. Theoretical contributions from the study suggest that critical events such as the Covid-19 pandemic should be considered as an important environmental factor when studying sickness presenteeism among self-employed.", "doi": "10.3389/fpsyg.2021.723036", "pmid": "34621220", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8490737"}], "notes": [], "created": "2021-10-10T15:07:50.898Z", "modified": "2021-10-10T15:07:50.911Z"}, {"entity": "publication", "iuid": "1c094d4be4214666a0f2dbbfc37eb5cd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1c094d4be4214666a0f2dbbfc37eb5cd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1c094d4be4214666a0f2dbbfc37eb5cd"}}, "title": "Risk-Assessment of Hospitalized Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infected Patients Using Laboratory Data and Immune Cell Morphological Assessment.", "authors": [{"family": "Kubik", "given": "Thane", "initials": "T"}, {"family": "Hou", "given": "Mary", "initials": "M"}, {"family": "Traverse", "given": "Tammie", "initials": "T"}, {"family": "Lareau", "given": "Mireille", "initials": "M"}, {"family": "Jenei", "given": "Veronika", "initials": "V"}, {"family": "Oberding", "given": "Lisa", "initials": "L"}, {"family": "Pillai", "given": "Dylan R", "initials": "DR"}, {"family": "Gillrie", "given": "Mark", "initials": "M"}, {"family": "Suryanarayan", "given": "Deepa", "initials": "D"}, {"family": "Sidhu", "given": "Davinder Singh", "initials": "DS"}, {"family": "Vergara-Lluri", "given": "Maria", "initials": "M"}, {"family": "Nakashima", "given": "Megan O", "initials": "MO"}, {"family": "Mahe", "given": "Etienne", "initials": "E"}], "type": "journal article", "published": "2021-09-20", "journal": {"title": "Arch Pathol Lab Med", "issn": "1543-2165", "issn-l": null}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious agent, with the propensity to cause severe illness. While vaccine uptake has been increasing in recent months, many regions remain at risk of significant coronavirus disease 19 (COVID-19) related healthcare burden. Health systems will continue to benefit from the availability of a variety of clinical and laboratory model when other triaging models are equivocal.\n\nTo validate previously reported clinical laboratory abnormalities seen in COVID-19 patients and identify what laboratory parameters might be outcome-predictive.\n\nWe undertook an observational study of hospital-admitted COVID-19 patients (n=113), looking at a broad selection of clinical, laboratory, peripheral blood smear, and outcome data over discrete discovery and validation periods from March 2020 to November 2020.\n\nWe confirmed the findings of previous studies noting derangement of a variety of laboratory parameters in COVID-19 patients, including peripheral blood morphological changes. We also devised a simple-to-use decision tree by which patients could be risk stratified on the basis of Red Blood Cell count, creatinine, urea, and atypical plasmacytoid lymphocyte (\"covidocyte\") count. This outcome classifier performed comparably to the World Health Organization clinical classifier and the neutrophil-lymphocyte ratio.\n\nOur data add to the increasing number of studies cataloguing laboratory changes in COVID-19, and support the clinical utility of incorporating blood morphological assessment in the workup of hospitalized COVID-19 patients.", "doi": "10.5858/arpa.2021-0368-SA", "pmid": "34543379", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "470568"}], "notes": [], "created": "2021-10-10T15:35:57.917Z", "modified": "2021-10-10T15:35:57.929Z"}, {"entity": "publication", "iuid": "a95016e0838f4ca0ba303faaf486166e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a95016e0838f4ca0ba303faaf486166e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a95016e0838f4ca0ba303faaf486166e"}}, "title": "Factors affecting Pakistani young adults' intentions to uptake COVID-19 vaccination: An extension of the theory of planned behavior.", "authors": [{"family": "Ullah", "given": "Irfan", "initials": "I", "orcid": "0000-0003-1100-101X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8d5a7e15ae6487cbdda0de3b2a531c3.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Malik", "given": "Najma Iqbal", "initials": "NI", "orcid": "0000-0002-3521-1014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c17242b513143b18e3bb8108f009ca4.json"}}, {"family": "Wu", "given": "Tzu-Yi", "initials": "TY"}, {"family": "Araban", "given": "Marzieh", "initials": "M", "orcid": "0000-0001-9920-0261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/267b131c24034c33b0ddff1b97f316a5.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-09-20", "journal": {"title": "Brain Behav", "issn": "2162-3279", "pages": "e2370", "issn-l": null}, "abstract": "Aside from personal beliefs, young adults' intention to uptake the COVID-19 vaccine can be influenced by their fear of COVID-19 and perceived infectability of COVID-19. The present study incorporated fear of COVID-19 and perceived infectability with the theory of planned behavior (TPB) to form an expanded TPB to analyze factors affecting Pakistani young adults' intentions to uptake the COVID-vaccine in Pakistan.\n\nA cross-sectional study was conducted and recruited participants from Pakistani social media users. The proposed extended TPB model was examined by using structural equation modeling.\n\nA total of 1034 individuals replied to the survey. The three factors of the original theory of planned behavior and the fear of COVID-19 were positively related to their intention to uptake COVID-19 vaccination (r = 0.25-0.66). Moreover, the perceived infectability positively influenced the three theories of planned behavioral factors and the fear of COVID-19 (r = 0.27-0.60), also affecting the participants' intentions to uptake COVID-19 vaccination.\n\nPerceived infectability was positively related to the participants' intentions to uptake COVID-19 vaccination, and perceived behavioral control was the strongest mediator. More evidence-based information concerning treatments and COVID-19 vaccination are needed to encourage individuals to uptake the vaccine.", "doi": "10.1002/brb3.2370", "pmid": "34543522", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:36:16.800Z", "modified": "2021-11-18T14:28:01.679Z"}, {"entity": "publication", "iuid": "26f7a8f9b07448189123efea423b99df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26f7a8f9b07448189123efea423b99df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26f7a8f9b07448189123efea423b99df"}}, "title": "Civil-Military Collaboration to Facilitate Rapid Deployment of a Mobile Laboratory in Early Response to COVID-19: A High-Readiness Exercise.", "authors": [{"family": "Bacchus", "given": "Philip", "initials": "P"}, {"family": "Nissen", "given": "Karolina", "initials": "K"}, {"family": "Berg", "given": "Johanna", "initials": "J"}, {"family": "Br\u00e5ve", "given": "Andreas", "initials": "A"}, {"family": "Gyll", "given": "Jenny", "initials": "J"}, {"family": "Larsson", "given": "Christer", "initials": "C"}, {"family": "Muradrasoli", "given": "Shaman", "initials": "S"}, {"family": "Tellstr\u00f6m", "given": "Andreas", "initials": "A"}, {"family": "Salaneck", "given": "Erik", "initials": "E"}], "type": "journal article", "published": "2021-09-20", "journal": {"title": "Health Secur", "issn": "2326-5108", "volume": "19", "issue": "5", "pages": "488-497", "issn-l": null}, "abstract": "Rapid and adaptable diagnostic capabilities are of great importance in the face of emerging infectious diseases. In an outbreak, timely establishment of diagnostic routines is crucial to identifying cases and preventing the spread of the disease, especially when faced with high-consequence pathogens. In this article, we describe a multiagency exercise including the rapid deployment and diagnostic adaptation of the Swedish Armed Forces mobile laboratory (biological field analysis laboratory) in the context of COVID-19. This deployment was initiated as a high-readiness exercise at the end of January 2020, when the global development of the outbreak was still uncertain. Through collaboration with the Public Health Agency of Sweden and a civilian hospital, a real-time reverse transcriptase polymerase chain reaction method specific to SARS-CoV-2 was made available and adapted to the mobile laboratory, and the team established and evaluated a functional and efficient diagnostic asset along with a logistical support chain. We also organized and evaluated mobile testing teams, and the method was later used in large-scale, national, cross-sectional COVID-19 surveys in several regions of Sweden. In this article, we focus on the challenges of overbridging the civil-military interface in this context and identifying lessons learned and added values to the response during the early pandemic. We propose that the experiences from this exercise and governmental agency collaboration are valuable in preparation for future outbreaks.", "doi": "10.1089/hs.2021.0011", "pmid": "34542343", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:35:34.328Z", "modified": "2021-11-18T14:21:28.133Z"}, {"entity": "publication", "iuid": "5d7ab7aa2e3f45998eec2af19db5271f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d7ab7aa2e3f45998eec2af19db5271f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d7ab7aa2e3f45998eec2af19db5271f"}}, "title": "Declining mortality of cerebral venous sinus thrombosis with thrombocytopenia after SARS-CoV-2 vaccination.", "authors": [{"family": "van de Munckhof", "given": "Anita", "initials": "A"}, {"family": "Krzywicka", "given": "Katarzyna", "initials": "K"}, {"family": "Aguiar de Sousa", "given": "Diana", "initials": "D", "orcid": "0000-0002-6702-7924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cc3515119a247859fe1fea025f703ef.json"}}, {"family": "S\u00e1nchez van Kammen", "given": "Mayte", "initials": "M"}, {"family": "Heldner", "given": "Mirjam R", "initials": "MR", "orcid": "0000-0002-3594-2159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8280f8c6ea3a486abae8acc6aa491985.json"}}, {"family": "Jood", "given": "Katarina", "initials": "K"}, {"family": "Lindgren", "given": "Erik", "initials": "E", "orcid": "0000-0002-7628-5044", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e973b3c74ff4e5cba42da605a13bc61.json"}}, {"family": "Tatlisumak", "given": "Turgut", "initials": "T"}, {"family": "Putaala", "given": "Jukka", "initials": "J"}, {"family": "Kremer Hovinga", "given": "Johanna A", "initials": "JA"}, {"family": "Middeldorp", "given": "Saskia", "initials": "S"}, {"family": "Levi", "given": "Marcel", "initials": "M"}, {"family": "Arnold", "given": "Marcel", "initials": "M"}, {"family": "Ferro", "given": "Jos\u00e9 M", "initials": "JM"}, {"family": "Coutinho", "given": "Jonathan M", "initials": "JM", "orcid": "0000-0002-8284-982X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98cadafdcc044688bab25a3d7f9562b9.json"}}], "type": "journal article", "published": "2021-09-18", "journal": {"title": "Eur J Neurol", "issn": "1468-1331", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "High mortality rates have been reported in patients with cerebral venous sinus thrombosis (CVST) due to vaccine-induced immune thrombotic thrombocytopenia (VITT) after vaccination with adenoviral vector SARS-CoV-2 vaccines. The aim of this study was to evaluate whether mortality of patients with CVST-VITT has decreased over time.\r\n\r\nWe used the EudraVigilance database of the European Medicines Agency to identify cases of CVST with concomitant thrombocytopenia occurring within 28 days of SARS-CoV-2 vaccination. Vaccines were grouped based on vaccine type (adenoviral or mRNA). Cases with CVST onset until 28 March were compared to cases after 28 March 2021, which was the day when the first scientific paper on VITT was published.\r\n\r\nWe identified 270 cases of CVST with thrombocytopenia, of which 266 (99%) occurred after adenoviral vector SARS-CoV-2 vaccination (ChAdOx1 nCoV-19 n=243, Ad26.COV2.S n=23). Reported mortality among adenoviral cases with onset up to 28 March 2021 was 47/99 (47%, 95%CI 37-58%) compared to 36/167 (22%, 95%CI 16-29%) in cases with onset after 28 March (p=<0.001). None of the 4 cases of CVST with thrombocytopenia occurring after mRNA vaccination died.\r\n\r\nReported mortality of CVST with thrombocytopenia after vaccination with adenoviral vector-based SARS-CoV-2 vaccines has significantly decreased over time, which may indicate a beneficial effect of earlier recognition and/or improved treatment on outcome after VITT.", "doi": "10.1111/ene.15113", "pmid": "34536256", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-09-20T16:56:40.912Z", "modified": "2021-12-07T15:26:05.448Z"}, {"entity": "publication", "iuid": "89ad16f8a9aa42e793d7f2ed72e2371c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/89ad16f8a9aa42e793d7f2ed72e2371c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/89ad16f8a9aa42e793d7f2ed72e2371c"}}, "title": "Monthlong Intubated Patient with Life-Threatening COVID-19 and Cerebral Microbleeds Suffers Only Mild Cognitive Sequelae at 8-Month Follow-up: A Case Report.", "authors": [{"family": "Backman", "given": "Linda", "initials": "L"}, {"family": "M\u00f6ller", "given": "Marika C", "initials": "MC"}, {"family": "Thelin", "given": "Eric P", "initials": "EP"}, {"family": "Dahlgren", "given": "Daniel", "initials": "D"}, {"family": "Deboussard", "given": "Catharina", "initials": "C"}, {"family": "\u00d6stlund", "given": "Gunilla", "initials": "G"}, {"family": "Lindau", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-09-17", "journal": {"title": "Arch Clin Neuropsychol", "issn": "1873-5843", "issn-l": null}, "abstract": "To elaborate on possible cognitive sequelae related to COVID-19, associated cerebrovascular injuries as well as the general consequences from intensive care. COVID-19 is known to have several, serious CNS-related consequences, but neuropsychological studies of severe COVID-19 are still rare.\n\nM., a 45-year-old man, who survived a severe COVID-19 disease course including Acute Respiratory Distress Syndrome (ARDS), cerebral microbleeds, and 35 days of mechanical ventilation, is described. We elaborate on M's recovery and rehabilitation process from onset to the 8-month follow-up. The cognitive functions were evaluated with a comprehensive screening battery at 4 weeks after extubation and at the 8-month follow-up.\n\nFollowing extubation, M. was delirious, reported visual hallucinations, and had severe sleeping difficulties. At about 3 months after COVID-19 onset, M. showed mild to moderate deficits on tests measuring processing speed, working memory, and attention. At assessments at 8 months, M. performed better, with results above average on tests measuring learning, memory, word fluency, and visuospatial functions. Minor deficits were still found regarding logical reasoning, attention, executive functioning, and processing speed. There were no lingering psychiatric symptoms. While M. had returned to a part-time job, he was not able to resume previous work-tasks.\n\nThis case-study demonstrates possible cognitive deficits after severe COVID-19 and emphasizes the need of a neuropsychological follow-up, with tests sensitive to minor deficits. The main findings of this report provide some support that the long-term prognosis for cognition in severe COVID-19 may be hopeful.", "doi": "10.1093/arclin/acab075", "pmid": "34530432", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6371352"}], "notes": [], "created": "2021-09-20T16:53:26.335Z", "modified": "2021-09-20T16:53:37.245Z"}, {"entity": "publication", "iuid": "8e5828a256014e558fdb864e18dd43d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e5828a256014e558fdb864e18dd43d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e5828a256014e558fdb864e18dd43d4"}}, "title": "Heart failure in COVID-19: the multicentre, multinational PCHF-COVICAV registry.", "authors": [{"family": "Sokolski", "given": "Mateusz", "initials": "M", "orcid": "0000-0001-9925-3566", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19276192c9dd4c47b35f4877b039b729.json"}}, {"family": "Trenson", "given": "Sander", "initials": "S", "orcid": "0000-0002-3902-0047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de369e2bc9d24a359ff118e2c1c7c79c.json"}}, {"family": "Sokolska", "given": "Justyna M", "initials": "JM", "orcid": "0000-0002-4759-5879", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8169d90790945999f1701f0f1e6ae26.json"}}, {"family": "D'Amario", "given": "Domenico", "initials": "D"}, {"family": "Meyer", "given": "Philippe", "initials": "P"}, {"family": "Poku", "given": "Nana K", "initials": "NK"}, {"family": "Biering-S\u00f8rensen", "given": "Tor", "initials": "T"}, {"family": "H\u00f8jbjerg Lassen", "given": "Mats C", "initials": "MC"}, {"family": "Skaarup", "given": "Kristoffer G", "initials": "KG"}, {"family": "Barge-Caballero", "given": "Eduardo", "initials": "E"}, {"family": "Pouleur", "given": "Anne-Catherine", "initials": "AC"}, {"family": "Stolfo", "given": "Davide", "initials": "D"}, {"family": "Sinagra", "given": "Gianfranco", "initials": "G"}, {"family": "Ablasser", "given": "Klemens", "initials": "K"}, {"family": "Muster", "given": "Viktoria", "initials": "V"}, {"family": "Rainer", "given": "Peter P", "initials": "PP"}, {"family": "Wallner", "given": "Markus", "initials": "M"}, {"family": "Chiodini", "given": "Alessandra", "initials": "A"}, {"family": "Heiniger", "given": "Pascal S", "initials": "PS"}, {"family": "Mikulicic", "given": "Fran", "initials": "F"}, {"family": "Schwaiger", "given": "Judith", "initials": "J"}, {"family": "Winnik", "given": "Stephan", "initials": "S"}, {"family": "Cakmak", "given": "Huseyin A", "initials": "HA"}, {"family": "Gaudenzi", "given": "Margherita", "initials": "M"}, {"family": "Mapelli", "given": "Massimo", "initials": "M"}, {"family": "Mattavelli", "given": "Irene", "initials": "I"}, {"family": "Paul", "given": "Matthias", "initials": "M"}, {"family": "Cabac-Pogorevici", "given": "Irina", "initials": "I"}, {"family": "Bouleti", "given": "Claire", "initials": "C"}, {"family": "Lilliu", "given": "Marzia", "initials": "M"}, {"family": "Minoia", "given": "Chiara", "initials": "C"}, {"family": "Dauw", "given": "Jeroen", "initials": "J"}, {"family": "Costa", "given": "J\u00e9r\u00f4me", "initials": "J"}, {"family": "Celik", "given": "Ahmet", "initials": "A"}, {"family": "Mewton", "given": "Nathan", "initials": "N"}, {"family": "Montenegro", "given": "Carlos E L", "initials": "CEL"}, {"family": "Matsue", "given": "Yuya", "initials": "Y"}, {"family": "Loncar", "given": "Goran", "initials": "G"}, {"family": "Marchel", "given": "Michal", "initials": "M"}, {"family": "Bechlioulis", "given": "Aris", "initials": "A"}, {"family": "Michalis", "given": "Lampros", "initials": "L"}, {"family": "D\u00f6rr", "given": "Marcus", "initials": "M"}, {"family": "Prihadi", "given": "Edgard", "initials": "E"}, {"family": "Schoenrath", "given": "Felix", "initials": "F"}, {"family": "Messroghli", "given": "Daniel R", "initials": "DR"}, {"family": "Mullens", "given": "Wilfried", "initials": "W"}, {"family": "Lund", "given": "Lars H", "initials": "LH"}, {"family": "Rosano", "given": "Giuseppe M C", "initials": "GMC", "orcid": "0000-0002-6868-4248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9db1f3658c8746599ddc172e6604c5b4.json"}}, {"family": "Ponikowski", "given": "Piotr", "initials": "P", "orcid": "0000-0002-3391-7064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9e5fe099039493dbc18fbfd549d4077.json"}}, {"family": "Ruschitzka", "given": "Frank", "initials": "F", "orcid": "0000-0001-5972-0596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/681536426df648299efac9c2e568ad13.json"}}, {"family": "Flammer", "given": "Andreas J", "initials": "AJ", "orcid": "0000-0002-1373-0630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/efbe793c83aa487ba4d0d6b021276670.json"}}], "type": "journal article", "published": "2021-09-17", "journal": {"title": "ESC Heart Fail", "issn": "2055-5822", "issn-l": null}, "abstract": "We assessed the outcome of hospitalized coronavirus disease 2019 (COVID-19) patients with heart failure (HF) compared with patients with other cardiovascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia). We further wanted to determine the incidence of HF events and its consequences in these patient populations.\n\nInternational retrospective Postgraduate Course in Heart Failure registry for patients hospitalized with COVID-19 and CArdioVascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia) was performed in 28 centres from 15 countries (PCHF-COVICAV). The primary endpoint was in-hospital mortality. Of 1974 patients hospitalized with COVID-19, 1282 had cardiovascular disease and/or risk factors (median age: 72 [interquartile range: 62-81] years, 58% male), with HF being present in 256 [20%] patients. Overall in-hospital mortality was 25% (n = 323/1282 deaths). In-hospital mortality was higher in patients with a history of HF (36%, n = 92) compared with non-HF patients (23%, n = 231, odds ratio [OR] 1.93 [95% confidence interval: 1.44-2.59], P < 0.001). After adjusting, HF remained associated with in-hospital mortality (OR 1.45 [95% confidence interval: 1.01-2.06], P = 0.041). Importantly, 186 of 1282 [15%] patients had an acute HF event during hospitalization (76 [40%] with de novo HF), which was associated with higher in-hospital mortality (89 [48%] vs. 220 [23%]) than in patients without HF event (OR 3.10 [2.24-4.29], P < 0.001).\n\nHospitalized COVID-19 patients with HF are at increased risk for in-hospital death. In-hospital worsening of HF or acute HF de novo are common and associated with a further increase in in-hospital mortality.", "doi": "10.1002/ehf2.13549", "pmid": "34533287", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-09-20T16:55:47.088Z", "modified": "2021-09-20T16:56:00.074Z"}, {"entity": "publication", "iuid": "dd02639389794c4c97fa776727dbcdb9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dd02639389794c4c97fa776727dbcdb9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dd02639389794c4c97fa776727dbcdb9"}}, "title": "Neurological manifestations of COVID-19: A comprehensive literature review and discussion of mechanisms.", "authors": [{"family": "Johansson", "given": "Anton", "initials": "A"}, {"family": "Mohamed", "given": "Mohamed S", "initials": "MS"}, {"family": "Moulin", "given": "Thiago C", "initials": "TC"}, {"family": "Schi\u00f6th", "given": "Helgi B", "initials": "HB"}], "type": "journal article", "published": "2021-09-15", "journal": {"title": "J Neuroimmunol", "issn": "1872-8421", "volume": "358", "pages": "577658", "issn-l": null}, "abstract": "Several neurological symptoms and complications have been described in association with COVID-19, such as anosmia, ageusia, encephalitis and Guillain-Barr\u00e9 syndrome. Here, we review the literature describing SARS-CoV-2-induced neurological manifestations and provide a comprehensive discussion of proposed mechanisms underlying the neurological pathophysiology. First, we analyse the neuroinvasiveness potential of the coronavirus family based on previous SARS-CoV-1 studies. Then, we describe the current evidence on COVID-19-induced nervous tissue damage, including processes behind brain vasculopathy and cytokine storm. We also discuss in detail anosmia and Guillain-Barr\u00e9 syndrome. Finally, we provide a summarised timeline of the main findings in the field. Future perspectives are presented, and suggestions of further investigations to clarify how SARS-COV-2 can affect the CNS.", "doi": "10.1016/j.jneuroim.2021.577658", "pmid": "34304141", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8272134"}, {"db": "pii", "key": "S0165-5728(21)00185-5"}], "notes": [], "created": "2021-08-05T07:03:24.380Z", "modified": "2023-01-13T13:24:48.655Z"}, {"entity": "publication", "iuid": "cdb5c73e050b4848a26ea799d4720749", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cdb5c73e050b4848a26ea799d4720749.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cdb5c73e050b4848a26ea799d4720749"}}, "title": "Internet addiction and psychological distress among Chinese schoolchildren before and during the COVID-19 outbreak: A latent class analysis.", "authors": [{"family": "Chen", "given": "I-Hua", "initials": "I"}, {"family": "Chen", "given": "Chao-Ying", "initials": "C"}, {"family": "Liu", "given": "Chieh-Hsiu", "initials": "C"}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Chen", "given": "Yu-Pin", "initials": "Y"}, {"family": "Kuo", "given": "Yi-Jie", "initials": "Y"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Wang", "given": "Shu-Mei", "initials": "S"}], "type": "journal article", "published": "2021-09-15", "journal": {"title": "J Behav Addict", "issn": "2063-5303", "issn-l": null, "volume": "10", "issue": "3", "pages": "731-746"}, "abstract": "The present longitudinal study examined the changes in problematic internet use (problematic smartphone use, problematic social media use, and problematic gaming) and changes in COVID-19-related psychological distress (fear of COVID-19 and worry concerning COVID-19) across three time-points (before the COVID-19 outbreak, during the initial stages of the COVID-19 outbreak, and during the COVID-19 outbreak recovery period).\r\n\r\nA total of 504 Chinese schoolchildren completed measures concerning problematic internet use and psychological distress across three time-points. Latent class analysis (LCA) was used to classify participants into three groups of problematic internet use comprising Group 1 (lowest level), Group 2 (moderate level), and Group 3 (highest level).\r\n\r\nStatistical analyses showed that as problematic use of internet-related activities declined among Group 3 participants across the three time points, participants in Group 1 and Group 2 had increased problematic use of internet-related activities. Although there was no between-group difference in relation to worrying concerning COVID-19 infection, Groups 2 and 3 had significantly higher levels of fear of COVID-19 than Group 1 during the COVID-19 recovery period. Regression analysis showed that change in problematic internet use predicted fear of COVID-19 during the recovery period.\r\n\r\nThe varied levels of problematic internet use among schoolchildren reflect different changing trends of additive behaviors during COVID-19 outbreak and recovery periods.", "doi": "10.1556/2006.2021.00052", "pmid": "34529588", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-09-20T16:52:00.538Z", "modified": "2021-11-18T14:20:35.797Z"}, {"entity": "publication", "iuid": "a404c0efa6384c3b9e7bcc42befc5f5a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a404c0efa6384c3b9e7bcc42befc5f5a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a404c0efa6384c3b9e7bcc42befc5f5a"}}, "title": "A Public Health Research Agenda for Managing Infodemics: Methods and Results of the First WHO Infodemiology Conference.", "authors": [{"family": "Calleja", "given": "Neville", "initials": "N", "orcid": "0000-0003-1800-2103", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b1ec37c898746abb5adc2a199f1ecf7.json"}}, {"family": "AbdAllah", "given": "AbdelHalim", "initials": "A", "orcid": "0000-0002-3441-9219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d660b25c91547e58020fb1aaad3f931.json"}}, {"family": "Abad", "given": "Neetu", "initials": "N", "orcid": "0000-0001-6999-4494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70cf4e5207a6403493e3490748c873ac.json"}}, {"family": "Ahmed", "given": "Naglaa", "initials": "N", "orcid": "0000-0003-3255-3948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e330ae7279149a9a88919e762a7d266.json"}}, {"family": "Albarracin", "given": "Dolores", "initials": "D", "orcid": "0000-0002-9575-1637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54e3e6521de74104ae67ec4abbe5b9da.json"}}, {"family": "Altieri", "given": "Elena", "initials": "E", "orcid": "0000-0001-6603-3399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a71adae43bdb435d9a282a876d7e33a7.json"}}, {"family": "Anoko", "given": "Julienne N", "initials": "JN", "orcid": "0000-0002-5436-311X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a355367e6c34aac9627c54c755c0005.json"}}, {"family": "Arcos", "given": "Ruben", "initials": "R", "orcid": "0000-0002-9665-5874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5f8621e19e94647b28a1ba01330da9d.json"}}, {"family": "Azlan", "given": "Arina Anis", "initials": "AA", "orcid": "0000-0001-5484-1188", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2510a9cda05d4bcf93be48fd0ed13525.json"}}, {"family": "Bayer", "given": "Judit", "initials": "J", "orcid": "0000-0003-0558-807X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7637e48fa0440a8b7e44d080339d552.json"}}, {"family": "Bechmann", "given": "Anja", "initials": "A", "orcid": "0000-0002-5588-5155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d144b5ff2fa74ce9ba8a5b01ecfd0f9f.json"}}, {"family": "Bezbaruah", "given": "Supriya", "initials": "S", "orcid": "0000-0002-4064-1297", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5601786cb9ce4e6fa0d71a5c493621ed.json"}}, {"family": "Briand", "given": "Sylvie C", "initials": "SC", "orcid": "0000-0001-6929-5335", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51ec51b7d86249469922ee9bf2b25c63.json"}}, {"family": "Brooks", "given": "Ian", "initials": "I", "orcid": "0000-0002-3793-3635", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bb0c9e7af664aff9ae71eb5d11a1872.json"}}, 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"Trewinnard", "given": "Tom", "initials": "T", "orcid": "0000-0001-7457-1322", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/360ee67acf5d4c31a8a2873c959bdac5.json"}}, {"family": "Turner", "given": "Shannon", "initials": "S", "orcid": "0000-0001-7425-3607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1df1ce4911eb47c9b4e0dbb4d7b8d058.json"}}, {"family": "Tworek", "given": "Heidi", "initials": "H", "orcid": "0000-0001-8825-7895", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b2de2bd58fc4c61b1b452d99c58d437.json"}}, {"family": "Uakkas", "given": "Saad", "initials": "S", "orcid": "0000-0001-6850-9901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9fbb96caef9a4c06831fa53fe57551bb.json"}}, {"family": "Vraga", "given": "Emily", "initials": "E", "orcid": "0000-0002-3016-3869", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb4c3fa0e0724326bdce31886a98011f.json"}}, {"family": "Wardle", "given": "Claire", "initials": "C", "orcid": "0000-0003-4597-8574", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72fd5fef1e8d4936ad46dbfba4004150.json"}}, {"family": "Wasserman", "given": "Herman", "initials": "H", "orcid": "0000-0002-2553-1989", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e43d8563aabc4fdb9dd23f5061226687.json"}}, {"family": "Wilhelm", "given": "Elisabeth", "initials": "E", "orcid": "0000-0002-4641-516X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd5af5af0a8348259121ef1a07fd5d61.json"}}, {"family": "W\u00fcrz", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3371-2736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4f15dda255248aea3ad25bbd7e6f035.json"}}, {"family": "Yau", "given": "Brian", "initials": "B", "orcid": "0000-0003-4255-9243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2178627e893c4a6a877dbbd168aa441b.json"}}, {"family": "Zhou", "given": "Lei", "initials": "L", "orcid": "0000-0002-6640-0774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98aff1a8ad36481c88971dcdc2cefcb8.json"}}, {"family": "Purnat", "given": "Tina D", "initials": "TD", "orcid": "0000-0002-0257-6631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a36f3dacd5946868c9e0ed41002c266.json"}}], "type": "journal article", "published": "2021-09-15", "journal": {"title": "JMIR Infodemiology", "issn": "2564-1891", "volume": "1", "issue": "1", "pages": "e30979", "issn-l": null}, "abstract": "An infodemic is an overflow of information of varying quality that surges across digital and physical environments during an acute public health event. It leads to confusion, risk-taking, and behaviors that can harm health and lead to erosion of trust in health authorities and public health responses. Owing to the global scale and high stakes of the health emergency, responding to the infodemic related to the pandemic is particularly urgent. Building on diverse research disciplines and expanding the discipline of infodemiology, more evidence-based interventions are needed to design infodemic management interventions and tools and implement them by health emergency responders.\n\nThe World Health Organization organized the first global infodemiology conference, entirely online, during June and July 2020, with a follow-up process from August to October 2020, to review current multidisciplinary evidence, interventions, and practices that can be applied to the COVID-19 infodemic response. This resulted in the creation of a public health research agenda for managing infodemics.\n\nAs part of the conference, a structured expert judgment synthesis method was used to formulate a public health research agenda. A total of 110 participants represented diverse scientific disciplines from over 35 countries and global public health implementing partners. The conference used a laddered discussion sprint methodology by rotating participant teams, and a managed follow-up process was used to assemble a research agenda based on the discussion and structured expert feedback. This resulted in a five-workstream frame of the research agenda for infodemic management and 166 suggested research questions. The participants then ranked the questions for feasibility and expected public health impact. The expert consensus was summarized in a public health research agenda that included a list of priority research questions.\n\nThe public health research agenda for infodemic management has five workstreams: (1) measuring and continuously monitoring the impact of infodemics during health emergencies; (2) detecting signals and understanding the spread and risk of infodemics; (3) responding and deploying interventions that mitigate and protect against infodemics and their harmful effects; (4) evaluating infodemic interventions and strengthening the resilience of individuals and communities to infodemics; and (5) promoting the development, adaptation, and application of interventions and toolkits for infodemic management. Each workstream identifies research questions and highlights 49 high priority research questions.\n\nPublic health authorities need to develop, validate, implement, and adapt tools and interventions for managing infodemics in acute public health events in ways that are appropriate for their countries and contexts. Infodemiology provides a scientific foundation to make this possible. This research agenda proposes a structured framework for targeted investment for the scientific community, policy makers, implementing organizations, and other stakeholders to consider.", "doi": "10.2196/30979", "pmid": "34604708", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "v1i1e30979"}, {"db": "pmc", "key": "PMC8448461"}], "notes": [], "created": "2021-10-11T18:01:06.780Z", "modified": "2021-10-11T18:01:08.959Z"}, {"entity": "publication", "iuid": "423363b4198b4e769954473f1692fc8f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/423363b4198b4e769954473f1692fc8f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/423363b4198b4e769954473f1692fc8f"}}, "title": "Systemic Human Neutrophil Lipocalin Associates with Severe Acute Kidney Injury in SARS-CoV-2 Pneumonia.", "authors": [{"family": "B\u00fclow Anderberg", "given": "Sara", "initials": "S"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Eriksson", "given": "Ann-Katrin", "initials": "A"}, {"family": "Venge", "given": "Per", "initials": "P"}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}], "type": "journal article", "published": "2021-09-14", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "10", "issue": "18", "pages": null}, "abstract": "Neutrophils have been suggested mediators of organ dysfunction in COVID-19. The current study investigated if systemic neutrophil activity, estimated by human neutrophil lipocalin (HNL) concentration in peripheral blood, is associated with acute kidney injury (AKI) development. A total of 103 adult patients admitted to intensive care, with PCR-confirmed SARS-CoV-2 infection, were prospectively included (Clinical Trials ID: NCT04316884). HNL was analyzed in plasma (P-HNL Dimer) and in whole blood (B-HNL). The latter after ex vivo activation with N-formyl-methionine-leucine-phenylalanine. All patients developed respiratory dysfunction and 62 (60%) were treated with invasive ventilation. Sixty-seven patients (65%) developed AKI, 18 (17%) progressed to AKI stage 3, and 14 (14%) were treated with continuous renal replacement therapy (CRRT). P-HNL Dimer was higher in patients with invasive ventilation, vasopressors, AKI, AKI stage 3, dialysis, and 30-day mortality (p < 0.001-0.046). B-HNL performed similarly with the exception of mild AKI and mortality (p < 0.001-0.004). The cohort was dichotomized by ROC estimated cutoff concentrations of 13.2 \u00b5g/L and 190 \u00b5g/L for P-HNL Dimer and B-HNL respectively. Increased cumulative risks for AKI, AKI stage 3, and death were observed if above the P-HNL cutoff and for AKI stage 3 if above the B-HNL cutoff. The relative risk of developing AKI stage 3 was nine and 39 times greater if above the cutoffs in plasma and whole blood, respectively, for CRRT eight times greater for both. In conclusion, systemically elevated neutrophil lipocalin, interpreted as increased neutrophil activity, was shown to be associated with an increased risk of severe AKI, renal replacement therapy, and mortality in COVID-19 patients with respiratory failure.", "doi": "10.3390/jcm10184144", "pmid": "34575252", "labels": {"Funder: VR": null, "Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "jcm10184144"}, {"db": "pmc", "key": "PMC8464787"}], "notes": [], "created": "2021-10-11T18:05:16.167Z", "modified": "2022-02-08T19:26:20.749Z"}, {"entity": "publication", "iuid": "8ba2f975b4274347abb1c16e6fdb96ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ba2f975b4274347abb1c16e6fdb96ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ba2f975b4274347abb1c16e6fdb96ef"}}, "title": "COVID-19 in Pregnancy and Early Childhood (COPE): study protocol for a prospective, multicentre biobank, survey and database cohort study.", "authors": [{"family": "Carlsson", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-1414-7279", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2453802e12b43008382f79aebd51ddf.json"}}, {"family": "Bergman", "given": "Lina", "initials": "L", "orcid": "0000-0001-5202-9428", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/edca37463d7c49c79fcdd7793717e1a1.json"}}, {"family": "Zaigham", "given": "Mehreen", "initials": "M", "orcid": "0000-0003-0129-1578", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/168018c2beee4b99868263d77bb67277.json"}}, {"family": "Linden", "given": "Karolina", "initials": "K", "orcid": "0000-0002-2792-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a16575cbdf5a4e0ebab52acaf2404273.json"}}, {"family": "Andersson", "given": "Ola", "initials": "O", "orcid": "0000-0002-3972-0457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77b8a87b252041f094508255b8a43df5.json"}}, {"family": "Veje", "given": "Malin", "initials": "M", "orcid": "0000-0001-5487-0616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de2e59c2ebcf41759a06fda11b6572bd.json"}}, {"family": "Sandstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Wikstr\u00f6m", "given": "Anna-Karin", "initials": "AK"}, {"family": "\u00d6stling", "given": "Hanna", "initials": "H"}, {"family": "Fadl", "given": "Helena", "initials": "H", "orcid": "0000-0002-2691-7525", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18fc6fdc8fee43348cd4283b0ad6334a.json"}}, {"family": "Domell\u00f6f", "given": "Magnus", "initials": "M", "orcid": "0000-0002-0726-7029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8aa25e36cc840e59e8308b8cca886c6.json"}}, {"family": "Blomberg", "given": "Marie", "initials": "M", "orcid": "0000-0003-4679-550X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa8f5a1024fe4cd1b8439ebef8d600c1.json"}}, {"family": "Brismar Wendel", "given": "Sophia", "initials": "S", "orcid": "0000-0002-9401-8062", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bfdd5280d71344dab0a68a2f4a4a2a99.json"}}, {"family": "\u00c5den", "given": "Ulrika", "initials": "U"}, {"family": "Sengpiel", "given": "Verena", "initials": "V", "orcid": "0000-0002-3608-7430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d43b587b94df49f88177d0c804ba7688.json"}}, {"family": "COPE study group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-09-14", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "9", "pages": "e049376", "issn-l": "2044-6055"}, "abstract": "There is limited knowledge on how the SARS-CoV-2 affects pregnancy outcomes. Studies investigating the impact of COVID-19 in early pregnancy are scarce and information on long-term follow-up is lacking.The purpose of this project is to study the impact of COVID-19 on pregnancy outcomes and long-term maternal and child health by: (1) establishing a database and biobank from pregnant women with COVID-19 and presumably non-infected women and their infants and (2) examining how women and their partners experience pregnancy, childbirth and early parenthood in the COVID-19 pandemic.\n\nThis is a national, multicentre, prospective cohort study involving 27 Swedish maternity units accounting for over 86 000 deliveries/year. Pregnant women are included when they: (1) test positive for SARS-CoV-2 (COVID-19 group) or (2) are non-infected and seek healthcare at one of their routine antenatal visits (screening group). Blood, as well as other biological samples, are collected at different time points during and after pregnancy. Child health up to 4 years of age and parent experience of pregnancy, delivery, early parenthood, healthcare and society in general will be examined using web-based questionnaires based on validated instruments. Short- and long-term health outcomes will be collected from Swedish health registers and the parents' experiences will be studied by performing qualitative interviews.\n\nConfidentiality aspects such as data encryption and storage comply with the General Data Protection Regulation and with ethical committee requirements. This study has been granted national ethical approval by the Swedish Ethical Review Authority (dnr 2020-02189 and amendments 2020-02848, 2020-05016, 2020-06696 and 2021-00870) and national biobank approval by the Biobank V\u00e4st (dnr B2000526:970). Results from the project will be published in peer-reviewed journals.\n\nNCT04433364.", "doi": "10.1136/bmjopen-2021-049376", "pmid": "34521667", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-049376"}, {"db": "pmc", "key": "PMC8441224"}, {"db": "ClinicalTrials.gov", "key": "NCT04433364"}], "notes": [], "created": "2021-09-20T06:23:16.618Z", "modified": "2021-11-19T10:46:33.086Z"}, {"entity": "publication", "iuid": "2893acfc94114a48bcf216469cf5f57e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2893acfc94114a48bcf216469cf5f57e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2893acfc94114a48bcf216469cf5f57e"}}, "title": "The SARS-CoV-2 spike protein is vulnerable to moderate electric fields.", "authors": [{"family": "Arbeitman", "given": "Claudia R", "initials": "CR", "orcid": "0000-0002-8302-6825", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e7be9f3366648e89aabf1604b071cfe.json"}}, {"family": "Rojas", "given": "Pablo", "initials": "P", "orcid": "0000-0003-3692-9228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee970dfd751549f2ab345dc82dfe7ced.json"}}, {"family": "Ojeda-May", "given": "Pedro", "initials": "P"}, {"family": "Garcia", "given": "Martin E", "initials": "ME", "orcid": "0000-0003-2418-1902", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/001e21f8f9c64da19ba99f3e5d3baaed.json"}}], "type": "journal article", "published": "2021-09-13", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "5407", "issn-l": "2041-1723"}, "abstract": "Most of the ongoing projects aimed at the development of specific therapies and vaccines against COVID-19 use the SARS-CoV-2 spike (S) protein as the main target. The binding of the spike protein with the ACE2 receptor (ACE2) of the host cell constitutes the first and key step for virus entry. During this process, the receptor binding domain (RBD) of the S protein plays an essential role, since it contains the receptor binding motif (RBM), responsible for the docking to the receptor. So far, mostly biochemical methods are being tested in order to prevent binding of the virus to ACE2. Here we show, with the help of atomistic simulations, that external electric fields of easily achievable and moderate strengths can dramatically destabilise the S protein, inducing long-lasting structural damage. One striking field-induced conformational change occurs at the level of the recognition loop L3 of the RBD where two parallel beta sheets, believed to be responsible for a high affinity to ACE2, undergo a change into an unstructured coil, which exhibits almost no binding possibilities to the ACE2 receptor. We also show that these severe structural changes upon electric-field application also occur in the mutant RBDs corresponding to the variants of concern (VOC) B.1.1.7 (UK), B.1.351 (South Africa) and P.1 (Brazil). Remarkably, while the structural flexibility of S allows the virus to improve its probability of entering the cell, it is also the origin of the surprising vulnerability of S upon application of electric fields of strengths at least two orders of magnitude smaller than those required for damaging most proteins. Our findings suggest the existence of a clean physical method to weaken the SARS-CoV-2 virus without further biochemical processing. Moreover, the effect could be used for infection prevention purposes and also to develop technologies for in-vitro structural manipulation of S. Since the method is largely unspecific, it can be suitable for application to other mutations in S, to other proteins of SARS-CoV-2 and in general to membrane proteins of other virus types.", "doi": "10.1038/s41467-021-25478-7", "pmid": "34518528", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-25478-7"}], "notes": [], "created": "2021-09-20T06:28:51.640Z", "modified": "2021-09-20T06:29:03.724Z"}, {"entity": "publication", "iuid": "1e64f19ee90a4d2ea6e4270ab56bdc03", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1e64f19ee90a4d2ea6e4270ab56bdc03.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1e64f19ee90a4d2ea6e4270ab56bdc03"}}, "title": "Psychometric Properties of the Fear of COVID-19 Scale: a Response to Mercado-Lara et al. \"Validity and Reliability of the Spanish Version of Fear of COVID-19 Scale in Colombian Physicians\".", "authors": [{"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "editorial", "published": "2021-09-13", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "pages": "1-3", "issn-l": null}, "abstract": "A paper reporting the psychometric properties of the Spanish Fear of COVID-19 Scale (FCV-19S) among Colombian physicians was recently published in the International Journal of Mental Health and Addiction. Although we welcome the translation and validation of our seven-item scale, this commentary outlines some major concerns we have with the study especially the removal of two items in developing a five-item FCV-19S. Based on these concerns, we strongly recommend that healthcare providers and researchers should use the five-item FCV-19S with caution.", "doi": "10.1007/s11469-021-00635-7", "pmid": "34539280", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "635"}, {"db": "pmc", "key": "PMC8436576"}], "notes": [], "created": "2021-10-10T15:34:42.465Z", "modified": "2021-10-10T15:34:42.495Z"}, {"entity": "publication", "iuid": "d23a819098cf4ae290dac7d35a599b0d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d23a819098cf4ae290dac7d35a599b0d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d23a819098cf4ae290dac7d35a599b0d"}}, "title": "Drawing lessons from the COVID-19 pandemic: Seven obstacles to learning from public inquiries in the wake of the crisis.", "authors": [{"family": "Eriksson", "given": "Kerstin", "initials": "K", "orcid": "0000-0002-0494-0089", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5167d81d812b4c479914399d0906560e.json"}}, {"family": "Staupe-Delgado", "given": "Reidar", "initials": "R", "orcid": "0000-0002-4244-9725", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8585167cd5824e429f1974ebbb254856.json"}}, {"family": "Holst", "given": "J\u00f8rgen", "initials": "J", "orcid": "0000-0001-7850-4493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4cef8db2e53049dcb56e3b94a40ae28d.json"}}], "type": "journal article", "published": "2021-09-13", "journal": {"title": "Risk Hazards Crisis Public Policy", "issn": "1944-4079", "issn-l": null}, "abstract": "On March 11, 2020, the World Health Organization declared the emerging COVID-19 threat a pandemic following the global spread of the virus. A year later, a number of governments are being handed the concluding reports of national public inquiries tasked with investigating responses, mishaps, and identifying lessons for the future. The present article aims to identify a set of learning obstacles that may hinder effective lessons drawing from the COVID-19 pandemic responses. The seven obstacles discussed in this article are: (1) retaining lessons and implementing them effectively, (2) effectively drawing lessons from other countries, (3) the potential for reforms to introduce unanticipated vulnerabilities elsewhere in the system, (4) political pressure, (5) drawing the conclusions from observations, (6) experts versus decision makers, and (7) reforms may not be related to the actual crisis. Exploring these obstacles will be central to future discussions concerning which kinds of responses will set precedent for future pandemics and global health crises.", "doi": "10.1002/rhc3.12240", "pmid": "34909110", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "RHC312240"}, {"db": "pmc", "key": "PMC8662287"}], "notes": [], "created": "2021-12-18T17:50:37.507Z", "modified": "2021-12-18T17:50:52.983Z"}, {"entity": "publication", "iuid": "58eb98e7c803402b8707615116755540", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/58eb98e7c803402b8707615116755540.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/58eb98e7c803402b8707615116755540"}}, "title": "Correction to: The Unyvero Hospital-Acquired pneumonia panel for diagnosis of secondary bacterial pneumonia in COVID-19 patients.", "authors": [{"family": "Tellapragada", "given": "Chaitanya", "initials": "C"}, {"family": "Giske", "given": "Christian G", "initials": "CG"}], "type": "published erratum", "published": "2021-09-13", "journal": {"title": "Eur J Clin Microbiol Infect Dis", "issn": "1435-4373", "issn-l": null}, "abstract": null, "doi": "10.1007/s10096-021-04331-1", "pmid": "34515876", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10096-021-04331-1"}, {"db": "pmc", "key": "PMC8435560"}], "notes": [], "created": "2021-09-20T06:29:31.711Z", "modified": "2021-09-20T06:30:31.524Z"}, {"entity": "publication", "iuid": "46682de72d7b45ba9a99097ebadafc6a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46682de72d7b45ba9a99097ebadafc6a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46682de72d7b45ba9a99097ebadafc6a"}}, "title": "COVID-19 infection among bartenders and waiters before and after pub lockdown.", "authors": [{"family": "Methi", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-7091-0806", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb34bc6f3c664b55b2240d9de0114cd4.json"}}, {"family": "Telle", "given": "Kjetil", "initials": "K"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2021-09-11", "journal": {"title": "Occup Environ Med", "issn": "1470-7926", "issn-l": null}, "abstract": "To assess how different bans on serving alcohol in Norwegian bars and restaurants were related to the detection of SARS-CoV-2 in bartenders and waiters and in persons in any occupation.\n\nIn 25 392 bartenders and waiters and 1 496 328 persons with other occupations (mean (SD) age 42.0 (12.9) years and 51.8% men), we examined the weekly rates of workers tested and detected with SARS-CoV-2, 1-10 weeks before and 1-5 weeks after implementation of different degrees of bans on serving alcohol in pubs and restaurants, across 102 Norwegian municipalities with: (1) full blanket ban, (2) partial ban with hourly restrictions (eg, from 22:00 hours) or (3) no ban, adjusted for age, sex, testing behaviour and population size.\n\nBy 4 weeks after the implementation of ban, COVID-19 infection among bartenders and waiters had been reduced by 60% (from 2.8 (95% CI 2.0 to 3.6) to 1.1 (95% CI 0.5 to 1.6) per 1000) in municipalities introducing full ban, and by almost 50% (from 2.5 (95% CI 1.5 to 3.5) to 1.3 (95% CI 0.4 to 2.2) per 1000) in municipalities introducing partial ban. A similar reduction within 4 weeks was also observed for workers in all occupations, both in municipalities with full (from 1.3 (95% CI 1.3 to 1.4) to 0.9 (95% CI 0.9 to 1.0)) and partial bans (from 1.2 (95% CI 1.1 to 1.3) to 0.5 (95% CI 0.5 to 0.6)).\n\nPartial bans on serving alcohol in bars and restaurants may be similarly associated with declines in confirmed COVID-19 infection as full bans.", "doi": "10.1136/oemed-2021-107502", "pmid": "34510004", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "oemed-2021-107502"}], "notes": [], "created": "2021-09-13T06:32:35.717Z", "modified": "2021-11-18T14:19:01.530Z"}, {"entity": "publication", "iuid": "1cb49e2c4e4246f1b9d225c6f4207247", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1cb49e2c4e4246f1b9d225c6f4207247.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1cb49e2c4e4246f1b9d225c6f4207247"}}, "title": "Unmet need of essential treatments for critical illness in Malawi.", "authors": [{"family": "Kayambankadzanja", "given": "Raphael Kazidule", "initials": "RK", "orcid": "0000-0003-2242-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48591b6c1f8c46b6ad8750de157c98a3.json"}}, {"family": "Schell", "given": "Carl Otto", "initials": "CO", "orcid": "0000-0002-7904-1336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a40b337b45b471d97a102c355c9d874.json"}}, {"family": "Mbingwani", "given": "Isaac", "initials": "I"}, {"family": "Mndolo", "given": "Samson Kwazizira", "initials": "SK"}, {"family": "Castegren", "given": "Markus", "initials": "M"}, {"family": "Baker", "given": "Tim", "initials": "T"}], "type": "journal article", "published": "2021-09-10", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "9", "pages": "e0256361"}, "abstract": "Critical illness is common throughout the world and has been the focus of a dramatic increase in attention during the COVID-19 pandemic. Severely deranged vital signs such as hypoxia, hypotension and low conscious level can identify critical illness. These vital signs are simple to check and treatments that aim to correct derangements are established, basic and low-cost. The aim of the study was to estimate the unmet need of such essential treatments for severely deranged vital signs in all adults admitted to hospitals in Malawi.\r\n\r\nWe conducted a point prevalence cross-sectional study of adult hospitalized patients in Malawi. All in-patients aged \u226518 on single days Queen Elizabeth Central Hospital (QECH) and Chiradzulu District Hospital (CDH) were screened. Patients with hypoxia (oxygen saturation <90%), hypotension (systolic blood pressure <90mmHg) and reduced conscious level (Glasgow Coma Scale <9) were included in the study. The a-priori defined essential treatments were oxygen therapy for hypoxia, intravenous fluid for hypotension and an action to protect the airway for reduced consciousness (placing the patient in the lateral position, insertion of an oro-pharyngeal airway or endo-tracheal tube or manual airway protection).\r\n\r\nOf the 1135 hospital in-patients screened, 45 (4.0%) had hypoxia, 103 (9.1%) had hypotension, and 17 (1.5%) had a reduced conscious level. Of those with hypoxia, 40 were not receiving oxygen (88.9%). Of those with hypotension, 94 were not receiving intravenous fluids (91.3%). Of those with a reduced conscious level, nine were not receiving an action to protect the airway (53.0%).\r\n\r\nThere was a large unmet need of essential treatments for critical illness in two hospitals in Malawi.", "doi": "10.1371/journal.pone.0256361", "pmid": "34506504", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-08206"}], "notes": [], "created": "2021-09-13T06:26:05.344Z", "modified": "2021-11-18T14:18:20.046Z"}, {"entity": "publication", "iuid": "d39b885aacba463da071d6ea31343e2a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d39b885aacba463da071d6ea31343e2a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d39b885aacba463da071d6ea31343e2a"}}, "title": "Outcomes associated with different vaccines in individuals with bipolar disorder and impact on the current COVID-19 pandemic- a systematic review.", "authors": [{"family": "Reininghaus", "given": "Eva Z", "initials": "EZ"}, {"family": "Manchia", "given": "Mirko", "initials": "M"}, {"family": "Dalkner", "given": "Nina", "initials": "N"}, {"family": "Bonkat", "given": "Nina", "initials": "N"}, {"family": "Squassina", "given": "Alessio", "initials": "A"}, {"family": "Hodl", "given": "Isabel", "initials": "I"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Reif", "given": "Andreas", "initials": "A"}, {"family": "Hajek", "given": "Tomas", "initials": "T"}, {"family": "Land\u00e9n", "given": "Mikael", "initials": "M"}, {"family": "Correll", "given": "Christoph U", "initials": "CU"}, {"family": "Scott", "given": "Jan", "initials": "J"}, {"family": "Etain", "given": "Bruno", "initials": "B"}, {"family": "Rietschel", "given": "Marcella", "initials": "M"}, {"family": "Bergink", "given": "Veerle", "initials": "V"}, {"family": "Martinez-Cengotitabengoa", "given": "Monica", "initials": "M"}, {"family": "Kessing", "given": "Lars Vedel", "initials": "LV"}, {"family": "Fagiolini", "given": "Andrea", "initials": "A"}, {"family": "Bauer", "given": "Michael", "initials": "M"}, {"family": "Goodwin", "given": "Guy", "initials": "G"}, {"family": "Gonzalez-Pinto", "given": "Ana", "initials": "A"}, {"family": "Kupka", "given": "Ralph W", "initials": "RW"}, {"family": "Schulze", "given": "Thomas G", "initials": "TG"}, {"family": "Lagerberg", "given": "Trine V", "initials": "TV"}, {"family": "Yildiz", "given": "Ay\u015feg\u00fcl", "initials": "A"}, {"family": "Henry", "given": "Chantal", "initials": "C"}, {"family": "Morken", "given": "Gunnar", "initials": "G"}, {"family": "Ritter", "given": "Phillip", "initials": "P"}, {"family": "Nieslen", "given": "Ren\u00e9 Ernst", "initials": "RE"}, {"family": "Licht", "given": "Rasmus W", "initials": "RW"}, {"family": "Bechdolf", "given": "Andreas", "initials": "A"}, {"family": "Andreassen", "given": "Ole A", "initials": "OA"}, {"family": "Fellendorf", "given": "Frederike Tabea", "initials": "FT"}], "type": "journal article", "published": "2021-09-10", "journal": {"title": "Eur Neuropsychopharmacol", "issn": "1873-7862", "issn-l": null}, "abstract": "Bipolar disorder (BD) might be associated with higher infection rates of coronavirus disease (COVID-19) which in turn could result in worsening the clinical course and outcome. This may be due to a high prevalence of somatic comorbidities and an increased risk of delays in and poorer treatment of somatic disease in patients with severe mental illness in general. Vaccination is the most important public health intervention to tackle the ongoing pandemic. We undertook a systematic review regarding the data on vaccinations in individuals with BD. Proportion of prevalence rates, efficacy and specific side effects of vaccinations and in individuals with BD were searched. Results show that only five studies have investigated vaccinations in individuals with BD, which substantially limits the interpretation of overall findings. Studies on antibody production after vaccinations in BD are very limited and results are inconsistent. Also, the evidence-based science on side effects of vaccinations in individuals with BD so far is poor.", "doi": "10.1016/j.euroneuro.2021.09.001", "pmid": "34607722", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0924-977X(21)00743-4"}, {"db": "pmc", "key": "PMC8429356"}], "notes": [], "created": "2021-10-11T17:55:05.232Z", "modified": "2021-10-11T17:55:05.250Z"}, {"entity": "publication", "iuid": "6cdab3b8bf64424e8314f89437a1daf2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6cdab3b8bf64424e8314f89437a1daf2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6cdab3b8bf64424e8314f89437a1daf2"}}, "title": "Histone H3 Cleavage in Severe COVID-19 ICU Patients.", "authors": [{"family": "Huckriede", "given": "Joram", "initials": "J"}, {"family": "de Vries", "given": "Femke", "initials": "F"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Wichapong", "given": "Kanin", "initials": "K"}, {"family": "Reutelingsperger", "given": "Chris", "initials": "C"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Garcia de Frutos", "given": "Pablo", "initials": "P"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Nicolaes", "given": "Gerry A F", "initials": "GAF"}], "type": "journal article", "published": "2021-09-10", "journal": {"title": "Front Cell Infect Microbiol", "issn": "2235-2988", "volume": "11", "pages": "694186", "issn-l": null}, "abstract": "The severity of coronavirus disease 19 (COVID-19) is associated with neutrophil extracellular trap (NET) formation. During NET formation, cytotoxic extracellular histones are released, the presence of which is linked to the initiation and progression of several acute inflammatory diseases. Here we study the presence and evolution of extracellular histone H3 and several other neutrophil-related molecules and damage-associated molecular patterns (DAMPs) in the plasma of 117 COVID-19-positive ICU patients. We demonstrate that at ICU admission the levels of histone H3, MPO, and DNA-MPO complex were all significantly increased in COVID-19-positive patients compared to control samples. Furthermore, in a subset of 54 patients, the levels of each marker remained increased after 4+ days compared to admission. Histone H3 was found in 28% of the patients on admission to the ICU and in 50% of the patients during their stay at the ICU. Notably, in 47% of histone-positive patients, we observed proteolysis of histone in their plasma. The overall presence of histone H3 during ICU stay was associated with thromboembolic events and secondary infection, and non-cleaved histone H3 was associated with the need for vasoactive treatment, invasive ventilation, and the development of acute kidney injury. Our data support the validity of treatments that aim to reduce NET formation and additionally underscore that more targeted therapies focused on the neutralization of histones should be considered as treatment options for severe COVID-19 patients.", "doi": "10.3389/fcimb.2021.694186", "pmid": "34568088", "labels": {"Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8461091"}], "notes": [], "created": "2021-10-11T18:03:16.463Z", "modified": "2021-10-11T18:03:16.478Z"}, {"entity": "publication", "iuid": "a92858c94ac44fe49013e243adcdf3fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a92858c94ac44fe49013e243adcdf3fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a92858c94ac44fe49013e243adcdf3fd"}}, "title": "A potential increase in adolescent nonsuicidal self-injury during covid-19: A comparison of data from three different time points during 2011 - 2021.", "authors": [{"family": "Zetterqvist", "given": "Maria", "initials": "M"}, {"family": "Jonsson", "given": "Linda S", "initials": "LS"}, {"family": "Landberg", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Svedin", "given": "Carl G\u00f6ran", "initials": "CG"}], "type": "journal article", "published": "2021-09-10", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "volume": "305", "pages": "114208", "issn-l": null}, "abstract": "Life-time prevalence of nonsuicidal self-injury (NSSI) has consistently been found to be around 17% in community samples of adolescents. Concerns of threats to mental health in adolescents during covid-19 have been raised. Life-time prevalence of NSSI in high school students in Sweden was compared using the same item to assess NSSI at three different time points. Results showed very similar prevalence of NSSI in 2011 and 2014 (17.2 % vs. 17.7 %), and an increase to 27.6 % during the pandemic of 2020-2021. Our findings imply a need to highlight the potential psychosocial consequences of covid-19 for young people.", "doi": "10.1016/j.psychres.2021.114208", "pmid": "34543849", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(21)00504-7"}, {"db": "pmc", "key": "PMC8448460"}], "notes": [], "created": "2021-10-10T15:37:09.274Z", "modified": "2021-10-10T15:37:09.284Z"}, {"entity": "publication", "iuid": "db528e826ef244f692dd82d08ecb0d8c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db528e826ef244f692dd82d08ecb0d8c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db528e826ef244f692dd82d08ecb0d8c"}}, "title": "Older adults' experiences of maintaining social participation: Creating opportunities and striving to adapt to changing situations.", "authors": [{"family": "L\u00f6fgren", "given": "Maria", "initials": "M", "orcid": "0000-0002-2403-4761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7013c636d1cb4a6f8e7e9e9ff51123f1.json"}}, {"family": "Larsson", "given": "Ellinor", "initials": "E", "orcid": "0000-0001-8513-0338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ced25f9687c3468ea8bbad6c8d0d23bd.json"}}, {"family": "Isaksson", "given": "Gunilla", "initials": "G", "orcid": "0000-0001-9143-9235", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a9d964a11714d6d86d6c163b645209e.json"}}, {"family": "Nyman", "given": "Anneli", "initials": "A", "orcid": "0000-0003-0467-4857", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48287349613a4cbb92e6023e9c18c335.json"}}], "type": "journal article", "published": "2021-09-09", "journal": {"title": "Scand J Occup Ther", "issn": "1651-2014", "pages": "1-11", "issn-l": null}, "abstract": "Social participation concerns the possibility of engaging in activities in interaction with others or society at large and contributes to the health and well-being of older adults. In contrast, a lack of social participation is associated with loneliness. It is, therefore, important to understand what strategies older adults use to maintain social participation.\n\nTo explore and describe older adults' experiences of maintaining social participation.\n\nNine older adults, aged 69-92 years, participated in interviews that were analysed through qualitative content analysis.\n\nThe overall findings reflect how older adults create opportunities for social participation by developing strategies and striving to adapt to changing situations, emphasizing how maintaining social participation is an active process. Preserving social participation requires motivation and an effort to take initiative to cultivate social relations, maintain community bonds, engage in social events and activities and stay connected with society.\n\nThese results may extend our understanding of strategies that older adults use, as well as the challenges they face when striving to adapt to new circumstances. This study may have implications for the practice of how to support older adults' social participation.", "doi": "10.1080/11038128.2021.1974550", "pmid": "34499845", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-09-13T06:07:30.008Z", "modified": "2021-09-13T06:07:30.131Z"}, {"entity": "publication", "iuid": "61b81c8d424d47928971c9d88be29179", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61b81c8d424d47928971c9d88be29179.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61b81c8d424d47928971c9d88be29179"}}, "title": "Heterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination", "authors": [{"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Vikstr\u00f6m", "given": "Linnea", "initials": "L"}, {"family": "Gwon", "given": "Yong Dae", "initials": "YD"}, {"family": "Persson", "given": "Ida Lisa", "initials": "IL"}, {"family": "Edin", "given": "Alicia", "initials": "A"}, {"family": "Bj\u00f6rsell", "given": "Tove", "initials": "T"}, {"family": "Dernstedt", "given": "Andy", "initials": "A"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Tevell", "given": "Staffan", "initials": "S"}, {"family": "Evander", "given": "Magnus", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Forsell", "given": "Mattias", "initials": "M", "orcid": "0000-0001-6904-742X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e41c0e1c9c7b499fb3d844d4c572e7bb.json"}}], "type": "journal-article", "published": "2021-09-09", "journal": {"title": "N Engl J Med", "issn": "1533-4406", "issn-l": null, "volume": "385", "issue": "11", "pages": "1049-1051"}, "abstract": null, "doi": "10.1056/nejmc2110716", "pmid": "34260850", "labels": {"Research Area: Vaccine": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Drug Discovery": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC8314734"}], "notes": [], "created": "2021-08-16T14:53:53.615Z", "modified": "2022-02-14T16:26:28.301Z"}, {"entity": "publication", "iuid": "6b6cc99a371b49e892efedf3224ad53d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b6cc99a371b49e892efedf3224ad53d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b6cc99a371b49e892efedf3224ad53d"}}, "title": "Patients with autoimmune polyendocrine syndrome type 1 have an increased susceptibility to severe herpesvirus infections.", "authors": [{"family": "Iivo", "given": "Hetem\u00e4ki", "initials": "H"}, {"family": "Saila", "given": "Laakso", "initials": "L"}, {"family": "Hannamari", "given": "V\u00e4limaa", "initials": "V"}, {"family": "Kleino", "given": "Iivari", "initials": "I"}, {"family": "Kek\u00e4l\u00e4inen", "given": "Eliisa", "initials": "E"}, {"family": "Outi", "given": "M\u00e4kitie", "initials": "M"}, {"family": "Petteri", "given": "Arstila T", "initials": "AT"}], "type": "journal article", "published": "2021-09-08", "journal": {"title": "Clin Immunol", "issn": "1521-7035", "pages": "108851", "issn-l": "1521-6616"}, "abstract": "Almost all patients with autoimmune polyendocrine syndrome type 1 (APS-1) have neutralizing antibodies against type 1 interferons (IFN), important mediators of antiviral defense. Recently, neutralizing anti-IFN antibodies were shown to be a risk factor of severe COVID-19. Here we show in a cohort of 44 patients with APS-1 that higher titers of neutralizing anti-IFN\u03b14 antibodies are associated with a higher and earlier incidence of VZV reactivation (herpes zoster). The patients also present with uncommonly severe clinical sequelae of herpetic infections. APS-1 patients had decreased humoral immune responses to varicella zoster virus, but cellular responses were comparable to healthy controls. These results suggest that blocking the type I interferon pathway in patients with APS-1 patients leads to a clinically significant immune deficiency, and susceptibility to herpesviruses should be taken into account when treating patients with APS-1.", "doi": "10.1016/j.clim.2021.108851", "pmid": "34508889", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1521-6616(21)00188-1"}], "notes": [], "created": "2021-09-13T06:29:34.119Z", "modified": "2021-09-13T06:29:34.132Z"}, {"entity": "publication", "iuid": "7417890877ab4f709614ce6eae82f5ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7417890877ab4f709614ce6eae82f5ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7417890877ab4f709614ce6eae82f5ef"}}, "title": "Autoimmunity roots of the thrombotic events after COVID-19 vaccination.", "authors": [{"family": "Elrashdy", "given": "Fatma", "initials": "F"}, {"family": "Tambuwala", "given": "Murtaza M", "initials": "MM"}, {"family": "Hassan", "given": "Sk Sarif", "initials": "SS"}, {"family": "Adadi", "given": "Parise", "initials": "P"}, {"family": "Seyran", "given": "Murat", "initials": "M"}, {"family": "El-Aziz", "given": "Tarek Mohamed Abd", "initials": "TMA"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Lal", "given": "Amos", "initials": "A"}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA"}, {"family": "Kandimalla", "given": "Ramesh", "initials": "R"}, {"family": "Bazan", "given": "Nicolas G", "initials": "NG"}, {"family": "Azad", "given": "Gajendra Kumar", "initials": "GK"}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Choudhury", "given": "Pabitra Pal", "initials": "PP"}, {"family": "Serrano-Aroca", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "Takayama", "given": "Kazuo", "initials": "K"}, {"family": "Chauhan", "given": "Gaurav", "initials": "G"}, {"family": "Pizzol", "given": "Damiano", "initials": "D"}, {"family": "Barh", "given": "Debmalya", "initials": "D"}, {"family": "Panda", "given": "Pritam Kumar", "initials": "PK"}, {"family": "Mishra", "given": "Yogendra K", "initials": "YK"}, {"family": "Pal\u00f9", "given": "Giorgio", "initials": "G"}, {"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Redwan", "given": "Elrashdy M", "initials": "EM"}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN"}], "type": "journal article", "published": "2021-09-08", "journal": {"title": "Autoimmun Rev", "issn": "1873-0183", "pages": "102941", "issn-l": null}, "abstract": "Although vaccination represents the most promising way to stop or contain the coronavirus disease 2019 (COVID-19) pandemic and safety and effectiveness of available vaccines were proven, a small number of individuals who received anti-SARS-CoV-2 vaccines developed a prothrombotic syndrome. Vaccine-induced immune thrombotic thrombocytopenia (VITT) can be triggered by the adenoviral vector-based vaccine, whereas lipid nanoparticle-mRNA-based vaccines can induce rare cases of deep vein thrombosis (DVT). Although the main pathogenic mechanisms behind this rare phenomenon have not yet been identified, both host and vaccine factors might be involved, with pathology at least in part being related to the vaccine-triggered autoimmune reaction. In this review, we are considering some aspects related to pathogenesis, major risk factors, as well as peculiarities of diagnosis and treatment of this rare condition.", "doi": "10.1016/j.autrev.2021.102941", "pmid": "34508917", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1568-9972(21)00216-0"}], "notes": [], "created": "2021-09-13T06:30:25.627Z", "modified": "2021-09-13T06:30:25.638Z"}, {"entity": "publication", "iuid": "93fcb469798a40c48b23d8aeebf129d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/93fcb469798a40c48b23d8aeebf129d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/93fcb469798a40c48b23d8aeebf129d5"}}, "title": "Repeated Covid-19 Infection Exists: A Case Series From Pakistan.", "authors": [{"family": "Haq", "given": "Zia Ul", "initials": "ZU"}, {"family": "Fazid", "given": "Sheraz", "initials": "S"}, {"family": "Yousafzai", "given": "Yasar Mehmood", "initials": "YM"}, {"family": "Noor", "given": "Mohammad", "initials": "M"}, {"family": "Ibrahimzai", "given": "Arsalan Khan", "initials": "AK"}, {"family": "Iqbal", "given": "Arif", "initials": "A"}, {"family": "Ullah", "given": "Naeem", "initials": "N"}, {"family": "Sherin", "given": "Akhtar", "initials": "A"}], "type": "journal article", "published": "2021-09-07", "journal": {"title": "J Ayub Med Coll Abbottabad", "issn": "1819-2718", "volume": "33", "issue": "3", "pages": "519-522", "issn-l": null}, "abstract": "Protection against SARS-CoV-2 in infected individuals of COVID-19 is lacking. We report a case series of repeated infections of SARS-CoV-2.\n\nA total of 12 patients were identified with repeated infections for SARS-CoV-2 from 25 April 2020 to 16 March 2021 from Pakistan. Repeated infection was defined as diagnosis of the SARS-CoV-2 with real-time reverse transcriptase-polymerase chain reaction (RT-PCR) tests in the first and second phase of infection after complete recovery from the first phase of infection with a negative RT-PCR.\n\nOf the 12 participants, 75% (n=9) were male and mean age of the participants were 40.1\u00b19.7 years. Mean duration between the first and second phase of infection was 184\u00b168.9 days. Patients presenting with mild infection in the first phase largely developed moderate to severe infection in the second phase. None of them were vaccinated.\n\nThe pandemic of COVID-19 is on the rise and repeated infection from SARS-CoV-2 is occurring.", "doi": null, "pmid": "34487669", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "9558/3124"}], "notes": [], "created": "2021-09-09T05:34:50.367Z", "modified": "2021-09-09T05:34:50.391Z"}, {"entity": "publication", "iuid": "94460c8969544292a92f17229253e3f5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/94460c8969544292a92f17229253e3f5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/94460c8969544292a92f17229253e3f5"}}, "title": "Author Response: CSF Biomarkers in Patients With COVID-19 and Neurologic Symptoms: A Case Series.", "authors": [{"family": "Ed\u00e9n", "given": "Arvid", "initials": "A"}], "type": "journal article", "published": "2021-09-07", "journal": {"title": "Neurology", "issn": "1526-632X", "volume": "97", "issue": "10", "pages": "510", "issn-l": "0028-3878"}, "abstract": null, "doi": "10.1212/WNL.0000000000012530", "pmid": "34489344", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "97/10/510"}], "notes": [], "created": "2021-09-09T05:35:27.340Z", "modified": "2023-06-19T14:45:47.724Z"}, {"entity": "publication", "iuid": "467597e93a374a49a004b6609177e767", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/467597e93a374a49a004b6609177e767.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/467597e93a374a49a004b6609177e767"}}, "title": "Update of the European Society for Vascular Surgery (ESVS) 2020 Clinical Practice Guidelines on the Management of Acute Limb Ischaemia in Light of the COVID-19 Pandemic, Based on a Scoping Review of the Literature.", "authors": [{"family": "Jongkind", "given": "Vincent", "initials": "V"}, {"family": "Earnshaw", "given": "Jonothan J", "initials": "JJ"}, {"family": "Bastos Gon\u00e7alves", "given": "Frederico", "initials": "F"}, {"family": "Cochennec", "given": "Frederic", "initials": "F"}, {"family": "Debus", "given": "E Sebastian", "initials": "ES"}, {"family": "Hinchliffe", "given": "Robert", "initials": "R"}, {"family": "Menyhei", "given": "Gabor", "initials": "G"}, {"family": "Svetlikov", "given": "Alexei V", "initials": "AV"}, {"family": "Tshomba", "given": "Yamume", "initials": "Y"}, {"family": "Van Den Berg", "given": "Jos C", "initials": "JC"}, {"family": "Bj\u00f6rck", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2021-09-06", "journal": {"title": "Eur J Vasc Endovasc Surg", "issn": "1532-2165", "issn-l": "1078-5884"}, "abstract": "To perform a scoping review of how patients with COVID-19 are affected by acute limb ischaemia (ALI) and evaluate the recommendations of the 2020 ESVS ALI Guidelines for these patients.\n\nResearch questions were defined, and a systematic literature search was performed following the PRISMA guidelines. Abstracts and unpublished literature were not included. The definition of ALI in this review is in accordance with the ESVS guidelines.\n\nMost identified papers were case reports or case series, although population based data and data from randomised controlled trials were also identified. In total, 114 unique and relevant papers were retrieved. Data were conflicting concerning whether the incidence of ALI increased, or remained unchanged, during the pandemic. Case reports and series reported ALI in patients who were younger and healthier than usual, with a greater proportion affecting the upper limb. Whether or not this is coincidental remains uncertain. The proportion of men/women affected seems unchanged. Most reported cases were in hospitalised patients with severe COVID-19. Patients with ALI as their first manifestation of COVID-19 were reported. Patients with ALI have a worse outcome if they have a simultaneous COVID-19 infection. High levels of D-dimer may predict the occurrence of arterial thromboembolic events in patients with COVID-19. Heparin resistance was observed. Anticoagulation should be given to hospitalised COVID-19 patients in prophylactic dosage. Most of the treatment recommendations from the ESVS Guidelines remained relevant, but the following were modified regarding patients with COVID-19 and ALI: 1) CTA imaging before revascularisation should include the entire aorta and iliac arteries; 2) there should be a high index of suspicion, early testing for COVID-19 infection and protective measures are advised; and 3) there should be preferential use of local or locoregional anaesthesia during revascularisation.\n\nAlthough the epidemiology of ALI has changed during the pandemic, the recommendations of the ESVS ALI Guidelines remain valid. The above mentioned minor modifications should be considered in patients with COVID-19 and ALI.", "doi": "10.1016/j.ejvs.2021.08.028", "pmid": "34686452", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1078-5884(21)00688-2"}, {"db": "pmc", "key": "PMC8418912"}], "notes": [], "created": "2021-10-26T18:17:23.347Z", "modified": "2021-10-26T18:17:23.360Z"}, {"entity": "publication", "iuid": "b4c697717ef34758b986290c183cf508", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b4c697717ef34758b986290c183cf508.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b4c697717ef34758b986290c183cf508"}}, "title": "The Impact of the COVID-19 Pandemic and Societal Infection Control Measures on Children and Adolescents' Mental Health: A Scoping Review.", "authors": [{"family": "Marchi", "given": "Jamile", "initials": "J"}, {"family": "Johansson", "given": "Nina", "initials": "N"}, {"family": "Sarkadi", "given": "Anna", "initials": "A"}, {"family": "Warner", "given": "Georgina", "initials": "G"}], "type": "journal article", "published": "2021-09-06", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "711791", "issn-l": "1664-0640"}, "abstract": "Background: The COVID-19 pandemic is primarily a crisis that affects people's physical health. However, it is well-known from previous epidemics and pandemics that there are other indirect negative impacts on mental health, among others. The purpose of this scoping review was to explore and summarise primary empirical research evidence on how the COVID-19 pandemic and societal infection control measures have impacted children and adolescents' mental health. Methods: A literature search was conducted in five scientific databases: PubMed, APA PsycINFO, Web of Science, CINHAL, and Social Science Premium Collection. The search string was designed using the Population (0-18 years), Exposure (COVID-19), Outcomes (mental health) framework. Mental health was defined broadly, covering mental well-being to mental disorders and psychiatric conditions. Results: Fifty-nine studies were included in the scoping review. Of these, 44 were cross-sectional and 15 were longitudinal studies. Most studies reported negative impact of the COVID-19 pandemic on child and adolescent mental health outcomes, yet the evidence was mixed. This was also the case for studies investigating societal control measures. Strong resilience, positive emotion regulation, physical activity, parental self-efficacy, family functioning and emotional regulation, and social support were reported as protective factors. On the contrary, emotional reactivity and experiential avoidance, exposure to excessive information, COVID-19 school concerns, presence of COVID-19 cases in the community, parental mental health problems, and high internet, social media and video game use were all identified as potentially harmful factors. Conclusions: Due to the methodological heterogeneity of the studies and geographical variation, it is challenging to draw definitive conclusions about the real impact of the COVID-19 pandemic on the mental health of children and adolescents. However, the existing body of research gives some insight to how parents, clinicians and policy makers can take action to mitigate the effects of COVID-19 and control measures. Interventions to promote physical activity and reduce screen time among children and adolescents are recommended, as well as parenting support programs.", "doi": "10.3389/fpsyt.2021.711791", "pmid": "34552516", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8451953"}], "notes": [], "created": "2021-10-27T05:16:37.510Z", "modified": "2021-10-27T05:17:05.092Z"}, {"entity": "publication", "iuid": "1c19c7f89b64441aa4a486609ca8c13f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1c19c7f89b64441aa4a486609ca8c13f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1c19c7f89b64441aa4a486609ca8c13f"}}, "title": "Storying COVID-19: fear, digitalisation, and the transformational potential of storytelling.", "authors": [{"family": "Essebo", "given": "Maja", "initials": "M", "orcid": "0000-0002-7173-2108", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b062eec25a734c4a87676eae288b5926.json"}}], "type": "journal article", "published": "2021-09-06", "journal": {"title": "Sustain Sci", "issn": "1862-4057", "pages": "1-10", "issn-l": null}, "abstract": "Stories are being increasingly recognised for their potential as creators, not only depicters, of change. As such, they are receiving greater interest within sustainability science, not least in the approaches specifically focused on transformative processes of co-creation. But while highly powerful, stories are confined by both inherent and external frameworks that, if not acknowledged, limit their transformative potential. This paper addresses two such critical issues-fear and digitalisation-and discusses the ways in which they influence how and with what effects stories can be told. It uses the COVID-19 pandemic as illustration of storytelling processes and outlines some of the ways in which we can, and cannot, draw parallels between pandemic and climate change storytelling.", "doi": "10.1007/s11625-021-01031-9", "pmid": "34512803", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "1031"}, {"db": "pmc", "key": "PMC8420142"}], "notes": [], "created": "2021-09-20T06:33:49.077Z", "modified": "2021-09-20T06:33:49.136Z"}, {"entity": "publication", "iuid": "2dea08cfe69143f3ab0f641cdcccf415", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2dea08cfe69143f3ab0f641cdcccf415.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2dea08cfe69143f3ab0f641cdcccf415"}}, "title": "Older Persons and the Right to Health in the Nordics during COVID-19.", "authors": [{"family": "\u00d3 Cathaoir", "given": "Katharina", "initials": "K", "orcid": "0000-0002-1535-9134", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0f0c704b3d146a8963031546ad087e9.json"}}, {"family": "Aasen", "given": "Henriette Sinding", "initials": "HS", "orcid": "0000-0002-4122-0902", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df3b82f21dc845749a0c800953237ce9.json"}}, {"family": "Gunnarsd\u00f3ttir", "given": "Hrefna D", "initials": "HD", "orcid": "0000-0001-7276-1587", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3cd2a452745b40c0bb99785a50af9ce1.json"}}, {"family": "Kimmel", "given": "Kaisa-Maria", "initials": "KM", "orcid": "0000-0003-4088-4616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/66cbcab717a94e6aa181fee91897f9cb.json"}}, {"family": "Lohiniva-Kerkel\u00e4", "given": "Mirva", "initials": "M"}, {"family": "Rognlien", "given": "Ida Gundersby", "initials": "IG", "orcid": "0000-0001-8065-6138", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ef852cd476e470ca1805358be2b8a70.json"}}, {"family": "Westerh\u00e4ll", "given": "Lotta Vahlne", "initials": "LV", "orcid": "0000-0002-5031-6236", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8fbf37e787e471988ffb05e9cf48b2f.json"}}], "type": "journal article", "published": "2021-09-06", "journal": {"title": "Eur J Health Law", "issn": "1571-8093", "issn-l": null, "volume": null, "issue": null, "pages": "1-28"}, "abstract": "We reflect on the extent to which Nordic countries have safeguarded the right to health of older persons during the pandemic in 2020. All Nordic states have ratified the International Covenant on Economic, Social and Cultural Rights and thereby committed to recognising the right to health. We use the AAAQ framework developed by the Committee on Economic, Social and Cultural Rights to draw attention to aspects of the respective states' responses. The COVID-19 pandemic has had significant impacts on the health of older persons, from the direct effects of the virus, such as illness and death, to indirect impacts, like isolation and loneliness. We find that Nordic states have at times failed to prioritise the full realisation of the core obligations of the right to health for older persons, namely, non-discrimination and provision of essential healthcare. Resource constraints cannot justify discrimination or failure to respect autonomy, integrity and human dignity.", "doi": "10.1163/15718093-bja10052", "pmid": "34610576", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:28:54.132Z", "modified": "2023-06-19T14:59:44.378Z"}, {"entity": "publication", "iuid": "cd377664d20c4cce90850186a7870427", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd377664d20c4cce90850186a7870427.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd377664d20c4cce90850186a7870427"}}, "title": "Diet quality and risk and severity of COVID-19: a prospective cohort study.", "authors": [{"family": "Merino", "given": "Jordi", "initials": "J", "orcid": "0000-0001-8312-1438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12ab049914a542b39affcfb4196861d2.json"}}, {"family": "Joshi", "given": "Amit D", "initials": "AD", "orcid": "0000-0001-7581-6934", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd29dfe6b8c742c894ca26d217080079.json"}}, {"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Leeming", "given": "Emily R", "initials": "ER", "orcid": "0000-0002-0531-4901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59a9e4a4912f451c861668efdd226c44.json"}}, {"family": "Mazidi", "given": "Mohsen", "initials": "M"}, {"family": "Drew", "given": "David A", "initials": "DA", "orcid": "0000-0002-8813-0816", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd3a2cffdc104f18b8684cf4f27d68b2.json"}}, {"family": "Gibson", "given": "Rachel", "initials": "R"}, {"family": "Graham", "given": "Mark S", "initials": "MS"}, {"family": "Lo", "given": "Chun-Han", "initials": "CH", "orcid": "0000-0001-8202-4513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a0d9111318f4084b64f47b5b56c8c85.json"}}, {"family": "Capdevila", "given": "Joan", "initials": "J"}, {"family": "Murray", "given": "Benjamin", "initials": "B"}, {"family": "Hu", "given": "Christina", "initials": "C"}, {"family": "Selvachandran", "given": "Somesh", "initials": "S"}, {"family": "Hammers", "given": "Alexander", "initials": "A"}, {"family": "Bhupathiraju", "given": "Shilpa N", "initials": "SN"}, {"family": "Sharma", "given": "Shreela V", "initials": "SV"}, {"family": "Sudre", "given": "Carole", "initials": "C"}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Chavarro", "given": "Jorge E", "initials": "JE"}, {"family": "Kwon", "given": "Sohee", "initials": "S"}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874802ae65824a90ba50eabdeabb8356.json"}}, {"family": "Willett", "given": "Walter C", "initials": "WC"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Spector", "given": "Timothy D", "initials": "TD"}, {"family": "Berry", "given": "Sarah", "initials": "S"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}], "type": "journal article", "published": "2021-09-06", "journal": {"title": "Gut", "issn": "1468-3288", "issn-l": null}, "abstract": "Poor metabolic health and unhealthy lifestyle factors have been associated with risk and severity of COVID-19, but data for diet are lacking. We aimed to investigate the association of diet quality with risk and severity of COVID-19 and its interaction with socioeconomic deprivation.\n\nWe used data from 592 571 participants of the smartphone-based COVID-19 Symptom Study. Diet information was collected for the prepandemic period using a short food frequency questionnaire, and diet quality was assessed using a healthful Plant-Based Diet Score, which emphasises healthy plant foods such as fruits or vegetables. Multivariable Cox models were fitted to calculate HRs and 95% CIs for COVID-19 risk and severity defined using a validated symptom-based algorithm or hospitalisation with oxygen support, respectively.\n\nOver 3 886 274 person-months of follow-up, 31 815 COVID-19 cases were documented. Compared with individuals in the lowest quartile of the diet score, high diet quality was associated with lower risk of COVID-19 (HR 0.91; 95% CI 0.88 to 0.94) and severe COVID-19 (HR 0.59; 95% CI 0.47 to 0.74). The joint association of low diet quality and increased deprivation on COVID-19 risk was higher than the sum of the risk associated with each factor alone (Pinteraction=0.005). The corresponding absolute excess rate per 10 000 person/months for lowest vs highest quartile of diet score was 22.5 (95% CI 18.8 to 26.3) among persons living in areas with low deprivation and 40.8 (95% CI 31.7 to 49.8) among persons living in areas with high deprivation.\n\nA diet characterised by healthy plant-based foods was associated with lower risk and severity of COVID-19. This association may be particularly evident among individuals living in areas with higher socioeconomic deprivation.", "doi": "10.1136/gutjnl-2021-325353", "pmid": "34489306", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "gutjnl-2021-325353"}], "notes": [], "created": "2021-09-09T05:35:10.324Z", "modified": "2021-09-09T05:35:10.430Z"}, {"entity": "publication", "iuid": "2f9299a3575e47c8a8e24ac9d6b3861a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2f9299a3575e47c8a8e24ac9d6b3861a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2f9299a3575e47c8a8e24ac9d6b3861a"}}, "title": "Innovative software systems for managing the impact of the COVID-19 pandemic.", "authors": [{"family": "Gill", "given": "Sukhpal Singh", "initials": "SS", "orcid": "0000-0002-3913-0369", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a5ab1ac135540acbd401a52536dd989.json"}}, {"family": "Vinuesa", "given": "Ricardo", "initials": "R", "orcid": "0000-0001-6570-5499", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/145cde54ca084cc6875f33fd7219cfc0.json"}}, {"family": "Balasubramanian", "given": "Venki", "initials": "V", "orcid": "0000-0001-6686-4424", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/876332738b834ed68f85594fe8516d8e.json"}}, {"family": "Ghosh", "given": "Soumya K", "initials": "SK", "orcid": "0000-0001-8359-581X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64a1a896d36a496ba60198a898d55a5d.json"}}], "type": "editorial", "published": "2021-09-05", "journal": {"title": "Softw Pract Exp", "issn": "0038-0644", "issn-l": null}, "abstract": null, "doi": "10.1002/spe.3023", "pmid": "34908601", "labels": {"Type: Other": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "SPE3023"}, {"db": "pmc", "key": "PMC8662097"}], "notes": [], "created": "2021-12-18T17:51:25.701Z", "modified": "2021-12-18T17:51:25.862Z"}, {"entity": "publication", "iuid": "351098c9c8274fe6ae586872001b4b7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/351098c9c8274fe6ae586872001b4b7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/351098c9c8274fe6ae586872001b4b7a"}}, "title": "DNA methylome-based validation of induced sputum as an effective protocol to study lung immunity: construction of a classifier of pulmonary cell types.", "authors": [{"family": "Das", "given": "Jyotirmoy", "initials": "J", "orcid": "0000-0002-5649-4658", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/883ec5a66e47458fa303f9df2572f669.json"}}, {"family": "Idh", "given": "Nina", "initials": "N"}, {"family": "Sikkeland", "given": "Liv Ingunn Bjoner", "initials": "LIB"}, {"family": "Paues", "given": "Jakob", "initials": "J"}, {"family": "Lerm", "given": "Maria", "initials": "M", "orcid": "0000-0002-5092-9892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a326e1fb7efa4c4f8f59e7572f6b83bc.json"}}], "type": "journal article", "published": "2021-09-05", "journal": {"title": "Epigenetics", "issn": "1559-2308", "pages": "1-12", "issn-l": null}, "abstract": "Flow cytometry is a classical approach used to define cell types in peripheral blood. While DNA methylation signatures have been extensively employed in recent years as an alternative to flow cytometry to define cell populations in peripheral blood, this approach has not been tested in lung-derived samples. Here, we compared bronchoalveolar lavage with a more cost-effective and less invasive technique based on sputum induction and developed a DNA methylome-based algorithm that can be used to deconvolute the cell types in such samples. We analysed the DNA methylome profiles of alveolar macrophages and lymphocytes cells isolated from the pulmonary compartment. The cells were isolated using two different methods, sputum induction and bronchoalveolar lavage. A strong positive correlation between the DNA methylome profiles of cells obtained with the two isolation methods was found. We observed the best correlation of the DNA methylomes when both isolation methods captured cells from the lower parts of the lungs. We also identified unique patterns of CpG methylation in DNA obtained from the two cell populations, which can be used as a signature to discriminate between the alveolar macrophages and lymphocytes by means of open-source algorithms. We validated our findings with external data and obtained results consistent with the previous findings. Our analysis opens up a new possibility to identify different cell populations from lung samples and promotes sputum induction as a tool to study immune cell populations from the lung.", "doi": "10.1080/15592294.2021.1969499", "pmid": "34482796", "labels": {"Funder: Hj\u00e4rt-Lungfonden": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://github.com/JD2112/AlveolarCellTypeDeconvolution", "description": "R scripts to analyze the Alveolar macrophages (HLA-DR+/CD3-) and lymphocytes (CD3+) specific cell types from DNA methylation analysis"}], "notes": [], "created": "2021-11-18T13:11:18.641Z", "modified": "2021-11-18T13:16:03.696Z"}, {"entity": "publication", "iuid": "e63ca637474a43d4b0632bdaa2cc9a0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e63ca637474a43d4b0632bdaa2cc9a0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e63ca637474a43d4b0632bdaa2cc9a0e"}}, "title": "The Impact of the COVID-19 Pandemic on Students' Mental Health and Sleep in Saudi Arabia.", "authors": [{"family": "Alyoubi", "given": "Azizah", "initials": "A"}, {"family": "Halstead", "given": "Elizabeth J", "initials": "EJ", "orcid": "0000-0002-5633-1859", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/139cecf838f041729fc9fa6e6a5bf725.json"}}, {"family": "Zambelli", "given": "Zoe", "initials": "Z"}, {"family": "Dimitriou", "given": "Dagmara", "initials": "D", "orcid": "0000-0002-6856-0595", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5de719ff390b404e8a7328a590ee500d.json"}}], "type": "journal article", "published": "2021-09-04", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "17", "pages": null}, "abstract": "Mental health problems are prevalent among university students in Saudi Arabia. This study aimed to investigate the impact of the COVID-19 pandemic on university students' mental health and sleep in Saudi Arabia.\r\n\r\nA total of 582 undergraduate students from Saudi Arabia aged between 18 and 45 years old (M = 20.91, SD = 3.17) completed a cross-sectional online questionnaire measuring depression, anxiety, stress, resilience, and insomnia during the COVID-19 pandemic (2020). Analysis included an independent samples t-test, one-way ANOVA, and Hierarchical regression analysis.\r\n\r\nUndergraduate students reported high levels of depression, anxiety, and perceived stress and low levels of resilience (p < 0.001) during the pandemic. In addition, students reported experiencing insomnia. A hierarchical regression analysis indicated that lower resilience, high levels of insomnia, having a pre-existing mental health condition, and learning difficulties (such as dyslexia, dyspraxia, or dyscalculia) were significantly associated with high levels of depression and stress. In addition, lower resilience, a high level of insomnia, and pre-existing mental health conditions were significantly associated with high levels of anxiety. Finally, a lower level of psychological resilience and a high level of insomnia were significantly associated with increased levels of depression, anxiety and stress within university students.\r\n\r\nThis study has provided evidence that a lower level of psychological resilience and insomnia were associated with mental health problems among undergraduate students in Saudi Arabia, thus enhancing psychological resilience and interventions to support sleep and mental health are vital to support student well-being outcomes throughout the pandemic.", "doi": "10.3390/ijerph18179344", "pmid": "34501935", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph18179344"}], "notes": [], "created": "2021-09-13T06:25:17.108Z", "modified": "2021-11-18T14:11:36.793Z"}, {"entity": "publication", "iuid": "371aa054a56c4cccace10eb7bfd8e9f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/371aa054a56c4cccace10eb7bfd8e9f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/371aa054a56c4cccace10eb7bfd8e9f2"}}, "title": "The Rapid Implementation of a Psychological Support Model for Frontline Healthcare Workers During the COVID-19 Pandemic: A Case Study and Process Evaluation.", "authors": [{"family": "Appelbom", "given": "Sophia", "initials": "S"}, {"family": "Bujacz", "given": "Aleksandra", "initials": "A"}, {"family": "Finnes", "given": "Anna", "initials": "A"}, {"family": "Ahlbeck", "given": "Karsten", "initials": "K"}, {"family": "Bromberg", "given": "Filip", "initials": "F"}, {"family": "Holmberg", "given": "Johan", "initials": "J"}, {"family": "Larsson", "given": "Liv", "initials": "L"}, {"family": "Olgren", "given": "Birgitta", "initials": "B"}, {"family": "Wanecek", "given": "Michael", "initials": "M"}, {"family": "Wetterborg", "given": "Dan", "initials": "D"}, {"family": "Wicksell", "given": "Rikard", "initials": "R"}], "type": "journal article", "published": "2021-09-03", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "713251", "issn-l": "1664-0640"}, "abstract": "The COVID-19 pandemic highlighted the need for psychological support initiatives directed toward frontline healthcare workers, which can be rapidly and sustainably implemented during an infectious disease outbreak. The current case study presents a comprehensive model of psychological support that was implemented at an intensive care unit (ICU) during the first wave of the COVID-19 pandemic. The psychological support model aimed at promoting a resilient stress reaction among frontline staff by protecting physical, social, and psychological resources. The initiatives, targeting different groups of workers, included education and training, peer support, psychologist-supervised and unsupervised group sessions, on-boarding for transferred staff, manager support, and individual sessions for workers experiencing strong stress reactions. The results of the process evaluation of this rapid implementation suggest that peer support initiatives as well as daily group sessions were the most appreciated forms of psychological support. Psychologists involved in organizing and providing the support highlighted several aspects of a successful implementation of the support model: offering support during work hours (preferably after shift), positive attitude of line managers that framed support initiatives as a team effort, and involvement of experienced psychologists able to quickly adjust the content of the support according to the current needs. The study also identified two main problems of the current implementation: the lack of efficient planning due to the use of volunteer work and the need for more structural resources on the organizational level to ensure long-term sustainability of the support model and its implementation among all groups of healthcare staff. The current case study highlights the importance of establishing permanent structural resources and routines for psychological support integrated in clinical practice by healthcare organizations to improve both rapid and sustainable response to future crises.", "doi": "10.3389/fpsyt.2021.713251", "pmid": "34539465", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8446385"}], "notes": [], "created": "2021-09-23T05:19:09.231Z", "modified": "2021-10-10T15:35:07.711Z"}, {"entity": "publication", "iuid": "6ad5487667444cb69faecd064e442597", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ad5487667444cb69faecd064e442597.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ad5487667444cb69faecd064e442597"}}, "title": "Fear During COVID-19 pandemic: Fear of COVID-19 Scale Measurement Properties.", "authors": [{"family": "Ullah", "given": "Irfan", "initials": "I", "orcid": "0000-0003-1100-101X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8d5a7e15ae6487cbdda0de3b2a531c3.json"}}, {"family": "Jaguga", "given": "Florence", "initials": "F", "orcid": "0000-0002-8381-6309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1abd85e0b8ec4d64afe50bf337816121.json"}}, {"family": "Ransing", "given": "Ramdas", "initials": "R"}, {"family": "Pereira-Sanchez", "given": "Victor", "initials": "V", "orcid": "0000-0002-2576-1549", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/244ab7530cd544b69173751dd9ca1cc6.json"}}, {"family": "Orsolini", "given": "Laura", "initials": "L", "orcid": "0000-0002-6882-3770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5aa4ac3eb4e44e208810fed3a72275be.json"}}, {"family": "Ori", "given": "Dorottya", "initials": "D", "orcid": "0000-0003-0878-165X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae84a3d4e3f047349ef01305a75cac8a.json"}}, {"family": "de Filippis", "given": "Renato", "initials": "R", "orcid": "0000-0001-6928-1224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d34493cdd004ea7926df58f411980bf.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}, {"family": "Adiukwu", "given": "Frances", "initials": "F", "orcid": "0000-0001-5543-1746", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41005a01477f44f995d839aacb60c8c9.json"}}, {"family": "Kilic", "given": "Ozge", "initials": "O", "orcid": "0000-0001-9764-343X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bef5a352062d42b8a18f30db5cd739c9.json"}}, {"family": "Hayatudeen", "given": "Nafisatu", "initials": "N"}, {"family": "Shoib", "given": "Sheikh", "initials": "S", "orcid": "0000-0002-3739-706X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8836f5d9f2a94346b1895a991b2ea5cc.json"}}, {"family": "Ojeahere", "given": "Margaret Isioma", "initials": "MI", "orcid": "0000-0002-0593-2400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/746f8d758e1d4384bca4c0a68d07eed4.json"}}, {"family": "Nagendrappa", "given": "Sachin", "initials": "S", "orcid": "0000-0002-8682-2982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d10848bc08245fc8668221fd48d5806.json"}}, {"family": "Handuleh", "given": "Jibril I M", "initials": "JIM", "orcid": "0000-0003-2662-1078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/266f47402be1449b8875f528d9f27e62.json"}}, {"family": "Dashi", "given": "Elona", "initials": "E", "orcid": "0000-0002-9280-2734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df7ff12c423f471287b289ccdba40fdb.json"}}, {"family": "Musami", "given": "Umar Baba", "initials": "UB", "orcid": "0000-0003-3540-4120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dcb21581a7ae43db9a449a79230a1d5b.json"}}, {"family": "Vahdani", "given": "Bita", "initials": "B", "orcid": "0000-0002-5727-8359", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a744c856d694c7c8c1a49396989a856.json"}}, {"family": "Ashrafi", "given": "Agaah", "initials": "A", "orcid": "0000-0003-1145-8001", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00434a52d4234c02871215b9c2c34feb.json"}}, {"family": "Jatchavala", "given": "Chonnakarn", "initials": "C", "orcid": "0000-0001-9765-2184", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2450b1839b534304859eeab927f8f138.json"}}, {"family": "Abbass", "given": "Zargham", "initials": "Z", "orcid": "0000-0002-5288-1079", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb121e28aa4b4c0ea21ba294f60773c4.json"}}, {"family": "El Halabi", "given": "Sarah", "initials": "S"}, {"family": "Ogunnubi", "given": "Oluseun Peter", "initials": "OP", "orcid": "0000-0001-9997-3379", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/17ebbf90d8fd48f9bc69a85d022929ea.json"}}, {"family": "Pinto da Costa", "given": "Mariana", "initials": "M"}, {"family": "Ramalho", "given": "Rodrigo", "initials": "R", "orcid": "0000-0002-2372-6854", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b990d3c278047a9b3878d47316ea4ed.json"}}], "type": "journal article", "published": "2021-09-03", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "issn-l": null, "volume": null, "issue": null, "pages": "1-10"}, "abstract": null, "doi": "10.1007/s11469-021-00528-9", "pmid": "34512215", "labels": {"Category: Public Health": null, "Type: Other": null}, "xrefs": [{"db": "pii", "key": "528"}, {"db": "pmc", "key": "PMC8415186"}], "notes": [], "created": "2021-09-20T06:35:03.095Z", "modified": "2021-11-18T14:11:04.137Z"}, {"entity": "publication", "iuid": "7144f9cd2f3f4eb782a60af0a795a9b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7144f9cd2f3f4eb782a60af0a795a9b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7144f9cd2f3f4eb782a60af0a795a9b2"}}, "title": "Autoimmune hepatitis triggered by COVID-19: A report of two cases.", "authors": [{"family": "Kaba\u00e7am", "given": "G\u00f6khan", "initials": "G"}, {"family": "Wahlin", "given": "Staffan", "initials": "S"}, {"family": "Efe", "given": "Cumali", "initials": "C", "orcid": "0000-0001-6593-5702", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cd621ab96e04e678b0188c48d54b90a.json"}}], "type": "letter", "published": "2021-09-03", "journal": {"title": "Liver Int", "issn": "1478-3231", "issn-l": null}, "abstract": null, "doi": "10.1111/liv.15044", "pmid": "34478591", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-09-06T05:53:14.195Z", "modified": "2021-09-06T05:53:14.253Z"}, {"entity": "publication", "iuid": "e4b92774ea2c47e1b13c32effc754650", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e4b92774ea2c47e1b13c32effc754650.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e4b92774ea2c47e1b13c32effc754650"}}, "title": "Assessing the capacity of symptom scores to predict COVID-19 positivity in Nigeria: a national derivation and validation cohort study.", "authors": [{"family": "Elimian", "given": "Kelly Osezele", "initials": "KO", "orcid": "0000-0003-2729-1613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/695dddf720414c3585d35b30184f0178.json"}}, {"family": "Aderinola", "given": "Olaolu", "initials": "O"}, {"family": "Gibson", "given": "Jack", "initials": "J"}, {"family": "Myles", "given": "Puja", "initials": "P"}, {"family": "Ochu", "given": "Chinwe Lucia", "initials": "CL", "orcid": "0000-0002-0630-7332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f390fa99a654ff899f5e9df6fbaf88e.json"}}, {"family": "King", "given": "Carina", "initials": "C"}, {"family": "Okwor", "given": "Tochi", "initials": "T"}, {"family": "Gaudenzi", "given": "Giulia", "initials": "G", "orcid": "0000-0003-4923-6965", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ee3937112f5484ab9acb5c54e4fabb4.json"}}, {"family": "Olayinka", "given": "Adebola", "initials": "A"}, {"family": "Zaiyad", "given": "Habib Garba", "initials": "HG"}, {"family": "Ohonsi", "given": "Cornelius", "initials": "C"}, {"family": "Ebhodaghe", "given": "Blessing", "initials": "B"}, {"family": "Dan-Nwafor", "given": "Chioma", "initials": "C"}, {"family": "Nwachukwu", "given": "William", "initials": "W"}, {"family": "Abdus-Salam", "given": "Ismail Adeshina", "initials": "IA"}, {"family": "Akande", "given": "Oluwatosin Wuraola", "initials": "OW", "orcid": "0000-0001-6906-895X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7ce51eb7a0b4a04b6af2802c88e2290.json"}}, {"family": "Falodun", "given": "Olanrewaju", "initials": "O"}, {"family": "Arinze", "given": "Chinedu", "initials": "C"}, {"family": "Ezeokafor", "given": "Chidiebere", "initials": "C"}, {"family": "Jafiya", "given": "Abubakar", "initials": "A"}, {"family": "Ojimba", "given": "Anastacia", "initials": "A"}, {"family": "Aremu", "given": "John Tunde", "initials": "JT"}, {"family": "Joseph", "given": "Emmanuel", "initials": "E"}, {"family": "Bowale", "given": "Abimbola", "initials": "A"}, {"family": "Mutiu", "given": "Bamidele", "initials": "B"}, {"family": "Saka", "given": "Babatunde", "initials": "B"}, {"family": "Jinadu", "given": "Arisekola", "initials": "A"}, {"family": "Hamza", "given": "Khadeejah", "initials": "K"}, {"family": "Ibeh", "given": "Christian", "initials": "C"}, {"family": "Bello", "given": "Shaibu", "initials": "S"}, {"family": "Asuzu", "given": "Michael", "initials": "M"}, {"family": "Mba", "given": "Nwando", "initials": "N"}, {"family": "Oladejo", "given": "John", "initials": "J"}, {"family": "Ilori", "given": "Elsie", "initials": "E"}, {"family": "Alfv\u00e9n", "given": "Tobias", "initials": "T"}, {"family": "Igumbor", "given": "Ehimario", "initials": "E"}, {"family": "Ihekweazu", "given": "Chikwe", "initials": "C"}], "type": "journal article", "published": "2021-09-03", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "9", "pages": "e049699"}, "abstract": "This study aimed to develop and validate a symptom prediction tool for COVID-19 test positivity in Nigeria.\r\n\r\nPredictive modelling study.\r\n\r\nAll Nigeria States and the Federal Capital Territory.\r\n\r\nA cohort of 43 221 individuals within the national COVID-19 surveillance dataset from 27 February to 27 August 2020. Complete dataset was randomly split into two equal halves: derivation and validation datasets. Using the derivation dataset (n=21 477), backward multivariable logistic regression approach was used to identify symptoms positively associated with COVID-19 positivity (by real-time PCR) in children (\u226417 years), adults (18-64 years) and elderly (\u226565 years) patients separately.\r\n\r\nWeighted statistical and clinical scores based on beta regression coefficients and clinicians' judgements, respectively. Using the validation dataset (n=21 744), area under the receiver operating characteristic curve (AUROC) values were used to assess the predictive capacity of individual symptoms, unweighted score and the two weighted scores.\r\n\r\nOverall, 27.6% of children (4415/15 988), 34.6% of adults (9154/26 441) and 40.0% of elderly (317/792) that had been tested were positive for COVID-19. Best individual symptom predictor of COVID-19 positivity was loss of smell in children (AUROC 0.56, 95% CI 0.55 to 0.56), either fever or cough in adults (AUROC 0.57, 95% CI 0.56 to 0.58) and difficulty in breathing in the elderly (AUROC 0.53, 95% CI 0.48 to 0.58) patients. In children, adults and the elderly patients, all scoring approaches showed similar predictive performance.\r\n\r\nThe predictive capacity of various symptom scores for COVID-19 positivity was poor overall. However, the findings could serve as an advocacy tool for more investments in resources for capacity strengthening of molecular testing for COVID-19 in Nigeria.", "doi": "10.1136/bmjopen-2021-049699", "pmid": "34479936", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-049699"}], "notes": [], "created": "2021-09-06T05:52:44.836Z", "modified": "2021-11-18T14:05:33.826Z"}, {"entity": "publication", "iuid": "462683b358b4463eb5acc3d9c705555b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/462683b358b4463eb5acc3d9c705555b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/462683b358b4463eb5acc3d9c705555b"}}, "title": "Separable Microneedle Patch to Protect and Deliver DNA Nanovaccines Against COVID-19.", "authors": [{"family": "Yin", "given": "Yue", "initials": "Y"}, {"family": "Su", "given": "Wen", "initials": "W"}, {"family": "Zhang", "given": "Jie", "initials": "J"}, {"family": "Huang", "given": "Wenping", "initials": "W"}, {"family": "Li", "given": "Xiaoyang", "initials": "X"}, {"family": "Ma", "given": "Haixia", "initials": "H"}, {"family": "Tan", "given": "Mixiao", "initials": "M"}, {"family": "Song", "given": "Haohao", "initials": "H"}, {"family": "Cao", "given": "Guoliang", "initials": "G"}, {"family": "Yu", "given": "Shengji", "initials": "S"}, {"family": "Yu", "given": "Di", "initials": "D"}, {"family": "Jeong", "given": "Ji Hoon", "initials": "JH", "orcid": "0000-0002-4836-3551", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ee9be966af4ebb9451f2a155ce453d.json"}}, {"family": "Zhao", "given": "Xiao", "initials": "X"}, {"family": "Li", "given": "Hui", "initials": "H"}, {"family": "Nie", "given": "Guangjun", "initials": "G", "orcid": "0000-0001-5040-9793", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bcb72746a3f4aa29992a27de22194b8.json"}}, {"family": "Wang", "given": "Hai", "initials": "H", "orcid": "0000-0002-1292-998X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db9fc13e307a43f48ca4bf63121051b1.json"}}], "type": "journal article", "published": "2021-09-02", "journal": {"title": "ACS Nano", "issn": "1936-086X", "issn-l": null}, "abstract": "The successful control of coronavirus disease 2019 (COVID-19) pandemic is not only relying on the development of vaccines, but also depending on the storage, transportation, and administration of vaccines. Ideally, nucleic acid vaccine should be directly delivered to proper immune cells or tissue (such as lymph nodes). However, current developed vaccines are normally treated through intramuscular injection, where immune cells do not normally reside. Meanwhile, current nucleic acid vaccines must be stored in a frozen state that may hinder their application in developing countries. Here, we report a separable microneedle (SMN) patch to deliver polymer encapsulated spike (or nucleocapsid) protein encoding DNA vaccines and immune adjuvant for efficient immunization. Compared with intramuscular injection, SMN patch can deliver nanovaccines into intradermal for inducing potent and durable adaptive immunity. IFN-\u03b3+CD4/8+ and IL-2+CD4/8+ T cells or virus specific IgG are significantly increased after vaccination. Moreover, in vivo results show the SMN patches can be stored at room temperature for at least 30 days without decreases in immune responses. These features of nanovaccines-laden SMN patch are important for developing advanced COVID-19 vaccines with global accessibility.", "doi": "10.1021/acsnano.1c03252", "pmid": "34472328", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-09-06T06:09:51.779Z", "modified": "2021-11-19T10:51:08.506Z"}, {"entity": "publication", "iuid": "78a51e65b378445a8fab820383056a5d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/78a51e65b378445a8fab820383056a5d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/78a51e65b378445a8fab820383056a5d"}}, "title": "Physiological respiratory parameters in pre-hospital patients with suspected COVID-19: A prospective cohort study.", "authors": [{"family": "M\u00e4lberg", "given": "Johan", "initials": "J", "orcid": "0000-0003-4289-8202", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f90af5371ce94f988a9f99a74306ab55.json"}}, {"family": "Hadziosmanovic", "given": "Nermin", "initials": "N"}, {"family": "Smekal", "given": "David", "initials": "D"}], "type": "journal article", "published": "2021-09-02", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "9", "pages": "e0257018", "issn-l": "1932-6203"}, "abstract": "The COVID-19 pandemic has presented emergency medical services (EMS) worldwide with the difficult task of identifying patients with COVID-19 and predicting the severity of their illness. The aim of this study was to investigate whether physiological respiratory parameters in pre-hospital patients with COVID-19 differed from those without COVID-19 and if they could be used to aid EMS personnel in the prediction of illness severity.\n\nPatients with suspected COVID-19 were included by EMS personnel in Uppsala, Sweden. A portable respiratory monitor based on pneumotachography was used to sample the included patient's physiological respiratory parameters. A questionnaire with information about present symptoms and background data was completed. COVID-19 diagnoses and hospital admissions were gathered from the electronic medical record system. The physiological respiratory parameters of patients with and without COVID-19 were then analyzed using descriptive statistical analysis and logistic regression.\n\nBetween May 2020 and January 2021, 95 patients were included, and their physiological respiratory parameters analyzed. Of these patients, 53 had COVID-19. Using adjusted logistic regression, the odds of having COVID-19 increased with respiratory rate (95% CI 1.000-1.118), tidal volume (95% CI 0.996-0.999) and negative inspiratory pressure (95% CI 1.017-1.152). Patients admitted to hospital had higher respiratory rates (p<0.001) and lower tidal volume (p = 0.010) compared to the patients who were not admitted. Using adjusted logistic regression, the odds of hospital admission increased with respiratory rate (95% CI 1.081-1.324), rapid shallow breathing index (95% CI 1.006-1.040) and dead space percentage of tidal volume (95% CI 1.027-1.159).\n\nPatients taking smaller, faster breaths with less pressure had higher odds of having COVID-19 in this study. Smaller, faster breaths and higher dead space percentage also increased the odds of hospital admission. Physiological respiratory parameters could be a useful tool in detecting COVID-19 and predicting hospital admissions, although more research is needed.", "doi": "10.1371/journal.pone.0257018", "pmid": "34473782", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-15446"}, {"db": "pmc", "key": "PMC8412304"}], "notes": [], "created": "2021-09-06T06:07:22.950Z", "modified": "2021-09-06T06:08:45.240Z"}, {"entity": "publication", "iuid": "bf9c58a68f07472384d6c71dcc2dc436", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf9c58a68f07472384d6c71dcc2dc436.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf9c58a68f07472384d6c71dcc2dc436"}}, "title": "Impact of the COVID-19 pandemic on the surveillance, prevention and control of antimicrobial resistance: a global survey.", "authors": [{"family": "Tomczyk", "given": "Sara", "initials": "S", "orcid": "0000-0001-6975-2663", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/547fdb65afe640fbb3f09de07366555b.json"}}, {"family": "Taylor", "given": "Angelina", "initials": "A"}, {"family": "Brown", "given": "Allison", "initials": "A"}, {"family": "de Kraker", "given": "Marlieke E A", "initials": "MEA", "orcid": "0000-0003-0903-8614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0791cb6f63f445a087fbb50ddf70a105.json"}}, {"family": "El-Saed", "given": "Aiman", "initials": "A"}, {"family": "Alshamrani", "given": "Majid", "initials": "M"}, {"family": "Hendriksen", "given": "Rene S", "initials": "RS"}, {"family": "Jacob", "given": "Megan", "initials": "M"}, {"family": "L\u00f6fmark", "given": "Sonja", "initials": "S"}, {"family": "Perovic", "given": "Olga", "initials": "O", "orcid": "0000-0001-5580-4629", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3353252a919e40069dd4b0235c672499.json"}}, {"family": "Shetty", "given": "Nandini", "initials": "N"}, {"family": "Sievert", "given": "Dawn", "initials": "D"}, {"family": "Smith", "given": "Rachel", "initials": "R"}, {"family": "Stelling", "given": "John", "initials": "J"}, {"family": "Thakur", "given": "Siddhartha", "initials": "S"}, {"family": "Vietor", "given": "Ann Christin", "initials": "AC"}, {"family": "Eckmanns", "given": "Tim", "initials": "T"}], "type": "journal article", "published": "2021-09-02", "journal": {"title": "J Antimicrob Chemother", "issn": "1460-2091", "issn-l": null}, "abstract": "The COVID-19 pandemic has had a substantial impact on health systems. The WHO Antimicrobial Resistance (AMR) Surveillance and Quality Assessment Collaborating Centres Network conducted a survey to assess the effects of COVID-19 on AMR surveillance, prevention and control.\n\nFrom October to December 2020, WHO Global Antimicrobial Resistance and Use Surveillance System (GLASS) national focal points completed a questionnaire, including Likert scales and open-ended questions. Data were descriptively analysed, income/regional differences were assessed and free-text questions were thematically analysed.\n\nSeventy-three countries across income levels participated. During the COVID-19 pandemic, 67% reported limited ability to work with AMR partnerships; decreases in funding were frequently reported by low- and middle-income countries (LMICs; P < 0.01). Reduced availability of nursing, medical and public health staff for AMR was reported by 71%, 69% and 64%, respectively, whereas 67% reported stable cleaning staff availability. The majority (58%) reported reduced reagents/consumables, particularly LMICs (P < 0.01). Decreased numbers of cultures, elective procedures, chronically ill admissions and outpatients and increased ICU admissions reported could bias AMR data. Reported overall infection prevention and control (IPC) improvement could decrease AMR rates, whereas increases in selected inappropriate IPC practices and antimicrobial prescribing could increase rates. Most did not yet have complete data on changing AMR rates due to COVID-19.\n\nThis was the first survey to explore the global impact of COVID-19 on AMR among GLASS countries. Responses highlight important actions to help ensure that AMR remains a global health priority, including engaging with GLASS to facilitate reliable AMR surveillance data, seizing the opportunity to develop more sustainable IPC programmes, promoting integrated antibiotic stewardship guidance, leveraging increased laboratory capabilities and other system-strengthening efforts.", "doi": "10.1093/jac/dkab300", "pmid": "34473285", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6362680"}], "notes": [], "created": "2021-09-06T06:09:23.666Z", "modified": "2021-09-06T06:09:23.763Z"}, {"entity": "publication", "iuid": "f83279fbc63c4980b12915cb5d036bc9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f83279fbc63c4980b12915cb5d036bc9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f83279fbc63c4980b12915cb5d036bc9"}}, "title": "Challenges in Preventive Practices and Risk Communication towards COVID-19: A Cross-Sectional Study in Bangladesh.", "authors": [{"family": "Rahman", "given": "Farah Naz", "initials": "FN", "orcid": "0000-0002-2265-2742", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35a313c259ed4fe3831ae74c581ee93e.json"}}, {"family": "Bhuiyan", "given": "Md Al Amin", "initials": "MAA", "orcid": "0000-0001-7385-0864", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af9df494efd648649fac724cf777d7d0.json"}}, {"family": "Hossen", "given": "Kabir", "initials": "K"}, {"family": "Khan", "given": "Hafiz T A", "initials": "HTA", "orcid": "0000-0002-1817-3730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b05ad34abbf241f0aa9d7cc4cf0010ac.json"}}, {"family": "Rahman", "given": "Akm Fazlur", "initials": "AF"}, {"family": "Dalal", "given": "Koustuv", "initials": "K", "orcid": "0000-0001-7393-796X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab5e44a17b7545988cb46cdf5b1f3e4e.json"}}], "type": "journal article", "published": "2021-09-02", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "17", "pages": null}, "abstract": "Bangladesh recently experienced a COVID-19 second wave, resulting in the highest number of new cases and deaths in a single day. This study aims to identify the challenges for COVID-19 preventive practices and risk communications and associated factors among Bangladeshi adults. A cross-sectional survey was conducted between December 2020 and January 2021 involving 1382 Bangladeshi adults (aged \u2265 18-years) in randomly selected urban and rural areas from all eight divisions in Bangladesh. Descriptive data analysis was conducted to highlight the challenges for preventive practices and risk communications for COVID-19. Multiple logistic regression analysis was used to determine the sociodemographic groups vulnerable to these challenges. Lack of availability of protective equipment (44.4%), crowded living situations/workspaces (36.8%), inadequate information on the proper use of protective measures (21.9%), inadequate handwashing and sanitation facilities (17.6%), and negative influences on family/friends (17.4%) were identified as barriers to COVID-19 preventive practices. It was also found that males (OR = 1.3, 95% CI = 1.01, 1.7), rural residents (OR = 1.5, 95% CI = 1.2, 2), respondents with a low level of education: no schooling vs. \u2265higher secondary (OR = 3.5, 95% CI = 2.3, 5.2), primary vs. \u2265higher secondary (OR = 2.5, 95% CI = 1.7, 3.8), respondents engaged in agricultural (OR = 1.7, 95% CI = 1.2, 2.4), laboring (OR = 3.2, 95% CI = 2, 5), and domestic works (OR = 1.6, 95% CI = 1.07, 2.5), and people with disabilities (OR = 1.7, 95% CI = 1.1, 2.6) were all likely to have difficulty in practicing effective COVID-19 protective behaviors. Respondents' education and occupation were significant predictors of inadequate understanding of COVID-19 risk communications and was identified as a problem among 17.4% of the respondents. A substantial percentage of Bangladeshi adults have difficulty practising COVID-19 protective behaviours and have poor comprehension of risk communications, particularly in rural areas and among those with low education. This research can aid policymakers in developing tailored COVID-19 risk communications and mitigation strategies to help prevent future waves of the pandemic.", "doi": "10.3390/ijerph18179259", "pmid": "34501847", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph18179259"}], "notes": [], "created": "2021-09-13T06:24:36.671Z", "modified": "2021-11-18T14:03:05.334Z"}, {"entity": "publication", "iuid": "fc8723392b684de496dd9cd342b7d8d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc8723392b684de496dd9cd342b7d8d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc8723392b684de496dd9cd342b7d8d0"}}, "title": "Association of cardiometabolic risk factors with hospitalisation or death due to COVID-19: population-based cohort study in Sweden (SCAPIS).", "authors": [{"family": "Tornhammar", "given": "Per", "initials": "P"}, {"family": "Jernberg", "given": "Tomas", "initials": "T"}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G"}, {"family": "Blomberg", "given": "Anders", "initials": "A"}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G"}, {"family": "Engvall", "given": "Jan", "initials": "J"}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f34c0d3602439abe6096293c7c732d.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Janson", "given": "Christer", "initials": "C", "orcid": "0000-0001-5093-6980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba296cda8ef74430ad5457e71b7dae94.json"}}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Sk\u00f6ld", "given": "C Magnus", "initials": "CM"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "S\u00f6derberg", "given": "Stefan", "initials": "S", "orcid": "0000-0001-9225-1306", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9507251cd84369a92d7f552d65f79e.json"}}, {"family": "Zaigham", "given": "Suneela", "initials": "S"}, {"family": "\u00d6stgren", "given": "Carl Johan", "initials": "CJ"}, {"family": "Andersson", "given": "Daniel Peter", "initials": "DP", "orcid": "0000-0003-4655-4837", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e35f15e626c045c191bd14a522a85c0e.json"}}, {"family": "Ueda", "given": "Peter", "initials": "P", "orcid": "0000-0002-3275-8743", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b5966168cb44c01b62e46aed9c8a02c.json"}}], "type": "journal article", "published": "2021-09-02", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "9", "pages": "e051359"}, "abstract": "To assess the association of cardiometabolic risk factors with hospitalisation or death due to COVID-19 in the general population.\r\n\r\nSwedish population-based cohort including 29 955 participants.\r\n\r\nCardiometabolic risk factors assessed between 2014 and 2018.\r\n\r\nHospitalisation or death due to COVID-19, as registered in nationwide registers from 31 January 2020 through 12 September 2020. Associations of cardiometabolic risk factors with the outcome were assessed using logistic regression adjusted for age, sex, birthplace and education.\r\n\r\nMean (SD) age was 61.2 (4.5) and 51.5% were women. 69 participants experienced hospitalisation or death due to COVID-19. Examples of statistically significant associations between baseline factors and subsequent hospitalisation or death due to COVID-19 included overweight (adjusted OR (aOR) vs normal weight 2.73 (95% CI 1.25 to 5.94)), obesity (aOR vs normal weight 4.09 (95% CI 1.82 to 9.18)), pre-diabetes (aOR vs normoglycaemia 2.56 (95% CI 1.44 to 4.55)), diabetes (aOR vs normoglycaemia 3.96 (95% CI 2.13 to 7.36)), sedentary time (aOR per hour/day increase 1.10 (95% CI 1.02 to 1.17)), grade 2 hypertension (aOR vs normotension 2.44 (95% CI 1.10 to 5.44)) and high density lipoprotein cholesterol (aOR per mmol/L increase 0.33 (95% CI 0.17 to 0.65)). Statistically significant associations were not observed for grade 1 hypertension (aOR vs normotension 1.03 (95% CI 0.55 to 1.96)), current smoking (aOR 0.56 (95% CI 0.24 to 1.30)), total cholesterol (aOR per mmol/L increase 0.90 (95% CI 0.71 to 1.13)), low density lipoprotein cholesterol (aOR per mmol/L increase 0.90 (95% CI 0.69 to 1.15)) and coronary artery calcium score (aOR per 10 units increase 1.00 (95% CI 0.99 to 1.01)).\r\n\r\nIn a large population-based sample from the general population, several cardiometabolic risk factors were associated with hospitalisation or death due to COVID-19.", "doi": "10.1136/bmjopen-2021-051359", "pmid": "34475186", "labels": {"Funder: Hj\u00e4rt-Lungfonden": null, "Funder: Vinnova": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-051359"}, {"db": "pmc", "key": "PMC8413466"}], "notes": [], "created": "2021-09-06T06:01:30.773Z", "modified": "2022-02-08T19:27:17.375Z"}, {"entity": "publication", "iuid": "8b8a1eaec13f4f0ea95e51be6748dd97", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b8a1eaec13f4f0ea95e51be6748dd97.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b8a1eaec13f4f0ea95e51be6748dd97"}}, "title": "Iodide supplementation of the anti-viral duox-lactoperoxidase activity may prevent some SARS-CoV-2 infections.", "authors": [{"family": "Smith", "given": "Michael L", "initials": "ML", "orcid": "0000-0003-4103-8614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4c9b76424464a188d2880c45a0f4303.json"}}, {"family": "Sharma", "given": "Sujata", "initials": "S"}, {"family": "Singh", "given": "Tej P", "initials": "TP", "orcid": "0000-0002-2886-7963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4aa57530849449bb3fd877de0182529.json"}}], "type": "letter", "published": "2021-09-01", "journal": {"title": "Eur J Clin Nutr", "issn": "1476-5640", "issn-l": null}, "abstract": null, "doi": "10.1038/s41430-021-00995-2", "pmid": "34471253", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41430-021-00995-2"}, {"db": "pmc", "key": "PMC8408568"}], "notes": [], "created": "2021-09-06T06:15:56.793Z", "modified": "2021-09-06T06:15:56.866Z"}, {"entity": "publication", "iuid": "1122b9f54daf4494987a99f1daf28185", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1122b9f54daf4494987a99f1daf28185.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1122b9f54daf4494987a99f1daf28185"}}, "title": "Distinct Metabolic Profile Associated with a Fatal Outcome in COVID-19 Patients during the Early Epidemic in Italy.", "authors": [{"family": "Saccon", "given": "Elisa", "initials": "E"}, {"family": "Bandera", "given": "Alessandra", "initials": "A", "orcid": "0000-0001-9440-4601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5fc84c1fbbf42d1bba7d98ae000b3b0.json"}}, {"family": "Scium\u00e8", "given": "Mariarita", "initials": "M"}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "Lashari", "given": "Abid A", "initials": "AA"}, {"family": "Aliberti", "given": "Stefano", "initials": "S"}, {"family": "Sachs", "given": "Michael C", "initials": "MC"}, {"family": "Billi", "given": "Filippo", "initials": "F"}, {"family": "Blasi", "given": "Francesco", "initials": "F"}, {"family": "Gabriel", "given": "Erin E", "initials": "EE"}, {"family": "Costantino", "given": "Giorgio", "initials": "G"}, {"family": "De Roberto", "given": "Pasquale", "initials": "P"}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Gori", "given": "Andrea", "initials": "A"}, {"family": "Peyvandi", "given": "Flora", "initials": "F"}, {"family": "Scudeller", "given": "Luigia", "initials": "L", "orcid": "0000-0001-7240-9567", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09948bf33c1e40a294d256f8b905f117.json"}}, {"family": "Canetta", "given": "Ciro", "initials": "C"}, {"family": "Lorson", "given": "Christian L", "initials": "CL"}, {"family": "Valenti", "given": "Luca", "initials": "L"}, {"family": "Singh", "given": "Kamal", "initials": "K"}, {"family": "Baldini", "given": "Luca", "initials": "L"}, {"family": "Fracchiolla", "given": "Nicola Stefano", "initials": "NS"}, {"family": "COVID-19 Network Working Group,", "given": "", "initials": ""}, {"family": "Neogi", "given": "Ujjwal", "initials": "U", "orcid": "0000-0002-0844-3338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5c27a627463945d992d74005f8a60d88.json"}}], "type": "journal article", "published": "2021-09-01", "journal": {"title": "Microbiol Spectr", "issn": "2165-0497", "pages": "e0054921", "issn-l": null}, "abstract": "In one year of the coronavirus disease 2019 (COVID-19) pandemic, many studies have described the different metabolic changes occurring in COVID-19 patients, linking these alterations to the disease severity. However, a complete metabolic signature of the most severe cases, especially those with a fatal outcome, is still missing. Our study retrospectively analyzes the metabolome profiles of 75 COVID-19 patients with moderate and severe symptoms admitted to Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Lombardy Region, Italy) following SARS-CoV-2 infection between March and April 2020. Italy was the first Western country to experience COVID-19, and the Lombardy Region was the epicenter of the Italian COVID-19 pandemic. This cohort shows a higher mortality rate compared to others; therefore, it represents a unique opportunity to investigate the underlying metabolic profiles of the first COVID-19 patients in Italy and to identify the potential biomarkers related to the disease prognosis and fatal outcome. IMPORTANCE Understanding the metabolic alterations occurring during an infection is a key element for identifying potential indicators of the disease prognosis, which are fundamental for developing efficient diagnostic tools and offering the best therapeutic treatment to the patient. Here, exploiting high-throughput metabolomics data, we identified the first metabolic profile associated with a fatal outcome, not correlated with preexisting clinical conditions or the oxygen demand at the moment of diagnosis. Overall, our results contribute to a better understanding of COVID-19-related metabolic disruption and may represent a useful starting point for the identification of independent prognostic factors to be employed in therapeutic practice.", "doi": "10.1128/Spectrum.00549-21", "pmid": "34468185", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: VR": null}, "xrefs": [], "notes": [], "created": "2021-09-06T06:20:28.618Z", "modified": "2021-10-10T15:12:11.738Z"}, {"entity": "publication", "iuid": "e3844727d8014bef83b79b9022d2dbd8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3844727d8014bef83b79b9022d2dbd8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3844727d8014bef83b79b9022d2dbd8"}}, "title": "Active matrix metalloproteinase-8 (aMMP-8) point-of-care test (POCT) in the COVID-19 pandemic.", "authors": [{"family": "Sorsa", "given": "Timo", "initials": "T"}, {"family": "Sahni", "given": "Vaibhav", "initials": "V"}, {"family": "Buduneli", "given": "Nurcan", "initials": "N"}, {"family": "Gupta", "given": "Shipra", "initials": "S"}, {"family": "R\u00e4is\u00e4nen", "given": "Ismo T", "initials": "IT", "orcid": "0000-0001-5821-5299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5688183e182e4194888dc98301077bab.json"}}, {"family": "Golub", "given": "Lorne M", "initials": "LM"}, {"family": "Lee", "given": "Hsi-Ming", "initials": "HM"}, {"family": "P\u00e4til\u00e4", "given": "Tommi", "initials": "T"}, {"family": "Bostanci", "given": "Nagihan", "initials": "N"}, {"family": "Meurman", "given": "Jukka", "initials": "J", "orcid": "0000-0001-6702-6836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ebb40fd79c04c618b3ae2908a70d317.json"}}, {"family": "P\u00e4rn\u00e4nen", "given": "Pirjo", "initials": "P"}, {"family": "Nwhator", "given": "Solomon O", "initials": "SO"}, {"family": "Singla", "given": "Mohita", "initials": "M"}, {"family": "Gauba", "given": "Krishan", "initials": "K"}], "type": "journal article", "published": "2021-09-01", "journal": {"title": "Expert Rev Proteomics", "issn": "1744-8387", "issn-l": null}, "abstract": "Active matrix metalloproteinase (aMMP)-8 utilized in point-of-care testing (POCT) is regarded as a potential biomarker for periodontal and peri-implant diseases. Various host and microbial factors eventually influence the expression, degranulation, levels and activation of aMMP-8. The type of oral fluids (saliva, mouthrinse, gingival crevicular and peri-implant sulcular fluids [GCF/PISF], respectively) affect the analysis.\n\nWith this background, we aimed to review here the recent studies on practical, inexpensive, noninvasive and quantitative mouthrinse and GCF/PISF chair-side POCT lateral flow aMMP-8 immunoassays (PerioSafe and ImplantSafe/ORALyzer) and how they help to detect, predict, monitor the course, treatment and prevention of periodontitis and peri-implantitis. The correlations of aMMP-8 POCT to other independent and catalytic activity assays of MMP-8 are also addressed.\n\nThe mouthrinse aMMP-8 POCT can also detect prediabetes/diabetes and tissue destructive oral side-effects due to the head and neck cancers' radiotherapy. Chlorhexidine and doxycycline can inhibit collagenolytic human neutrophil and GCF aMMP-8. Furthermore, by a set of case-series we demonstrate the potential of mouthrinse aMMP-8 POCT to real-time/online detect periodontitis as a potential risk disease for coronavirus disease 2019 (COVID-19). The clinical interdisciplinary utilization of aMMP-8 POCT requires additional oral, medical and interdisciplinary studies.", "doi": "10.1080/14789450.2021.1976151", "pmid": "34468272", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-09-06T06:20:03.652Z", "modified": "2021-09-06T06:20:03.727Z"}, {"entity": "publication", "iuid": "d462e8f607604abbbff7f19df78740fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d462e8f607604abbbff7f19df78740fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d462e8f607604abbbff7f19df78740fc"}}, "title": "Vaccine effectiveness against infection with the Delta (B.1.617.2) variant, Norway, April to August 2021.", "authors": [{"family": "Sepp\u00e4l\u00e4", "given": "Elina", "initials": "E"}, {"family": "Veneti", "given": "Lamprini", "initials": "L"}, {"family": "Starrfelt", "given": "Jostein", "initials": "J"}, {"family": "Danielsen", "given": "Anders Skyrud", "initials": "AS"}, {"family": "Bragstad", "given": "Karoline", "initials": "K"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "Taxt", "given": "Arne Michael", "initials": "AM"}, {"family": "Watle", "given": "Sara Viksmoen", "initials": "SV"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "35", "pages": null}, "abstract": "Some variants of SARS-CoV-2 are associated with increased transmissibility, increased disease severity or decreased vaccine effectiveness (VE). In this population-based cohort study (n = 4,204,859), the Delta variant was identified in 5,430 (0.13%) individuals, of whom 84 were admitted to hospital. VE against laboratory confirmed infection with the Delta variant was 22.4% among partly vaccinated (95% confidence interval (CI): 17.0-27.4) and 64.6% (95% CI: 60.6-68.2) among fully vaccinated individuals, compared with 54.5% (95% CI: 50.4-58.3) and 84.4% (95%CI: 81.8-86.5) against the Alpha variant.", "doi": "10.2807/1560-7917.ES.2021.26.35.2100793", "pmid": "34477054", "labels": {"Category: Genomics & transcriptomics": null, "Category: Drug Discovery": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-09-06T05:53:34.921Z", "modified": "2021-11-29T06:15:04.418Z"}, {"entity": "publication", "iuid": "45a576151c394ef38702a583f1654699", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/45a576151c394ef38702a583f1654699.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/45a576151c394ef38702a583f1654699"}}, "title": "Unequal Labour Market Impacts of COVID-19 in Sweden \u2014 But Not Between Women and Men", "authors": [{"family": "Campa", "given": "Pamela", "initials": "P"}, {"family": "Roine", "given": "Jesper", "initials": "J"}, {"family": "Str\u00f6mberg", "given": "Svante", "initials": "S"}], "type": "journal-article", "published": "2021-09-00", "journal": {"title": "Intereconomics", "issn": "0020-5346", "issn-l": null, "volume": "56", "issue": "5", "pages": "264-269"}, "abstract": null, "doi": "10.1007/s10272-021-0996-3", "pmid": null, "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:52:36.938Z", "modified": "2022-11-23T08:52:04.923Z"}, {"entity": "publication", "iuid": "a0b638ade2174bf6ad9cea1ba3806e93", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a0b638ade2174bf6ad9cea1ba3806e93.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a0b638ade2174bf6ad9cea1ba3806e93"}}, "title": "Trust in the government increases financial well-being and general well-being during COVID-19.", "authors": [{"family": "Barrafrem", "given": "Kinga", "initials": "K"}, {"family": "Tingh\u00f6g", "given": "Gustav", "initials": "G"}, {"family": "V\u00e4stfj\u00e4ll", "given": "Daniel", "initials": "D"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "J Behav Exp Finance", "issn": "2214-6350", "issn-l": null, "volume": "31", "issue": null, "pages": "100514"}, "abstract": "We investigate the antecedents of subjective financial well-being and general well-being during the ongoing COVID-19 pandemic. In an online survey conducted in the midst of COVID-19 pandemic with over 1000 Swedish participants we found that distrust in the government to cope with financial (but not healthcare) challenges of the pandemic was negatively related to the feeling of financial security. In a structural equation model, we also show that trust in government to deal with financial challenges of COVID-19 pandemic has a significant impact on general well-being through the mediating channel of financial well-being. In addition, trust in government to deal with healthcare challenges of COVID-19 pandemic has a significant direct impact on individuals' general well-being. Our findings have important implications for public policy as they highlight the importance of citizens' trust in well-functioning governmental institutions to help cope with not only healthcare, but also financial challenges of an ongoing pandemic.", "doi": "10.1016/j.jbef.2021.100514", "pmid": "34545323", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2214-6350(21)00058-7"}, {"db": "pmc", "key": "PMC8444950"}], "notes": [], "created": "2021-10-27T05:11:02.378Z", "modified": "2021-11-18T14:01:18.560Z"}, {"entity": "publication", "iuid": "bf72161a487f403ab690c95bc4b98b16", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf72161a487f403ab690c95bc4b98b16.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf72161a487f403ab690c95bc4b98b16"}}, "title": "Thirty-Day Outcomes of Children and Adolescents With COVID-19: An International Experience.", "authors": [{"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "Vizcaya", "given": "David", "initials": "D"}, {"family": "Pistillo", "given": "Andrea", "initials": "A"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Lai", "given": "Lana Yin Hui", "initials": "LYH"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A"}, {"family": "Ahmed", "given": "Waheed-Ul-Rahman", "initials": "WU"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Burn", "given": "Edward", "initials": "E"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Blacketer", "given": "Clair", "initials": "C"}, {"family": "DuVall", "given": "Scott", "initials": "S"}, {"family": "Falconer", "given": "Thomas", "initials": "T"}, {"family": "Fernandez-Bertolin", "given": "Sergio", "initials": "S"}, {"family": "Fortin", "given": "Stephen", "initials": "S"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Gong", "given": "Mengchun", "initials": "M"}, {"family": "Tan", "given": "Eng Hooi", "initials": "EH"}, {"family": "Huser", "given": "Vojtech", "initials": "V"}, {"family": "Iveli", "given": "Pablo", "initials": "P"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Recalde", "given": "Martina", "initials": "M"}, {"family": "Roel", "given": "Elena", "initials": "E"}, {"family": "Schilling", "given": "Lisa M", "initials": "LM"}, {"family": "Shah", "given": "Nigam H", "initials": "NH"}, {"family": "Shah", "given": "Karishma", "initials": "K"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhang", "given": "Ying", "initials": "Y"}, {"family": "Williams", "given": "Andrew E", "initials": "AE"}, {"family": "Reich", "given": "Christian G", "initials": "CG"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Rijnbeek", "given": "Peter", "initials": "P"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}], "type": "comparative study", "published": "2021-09-00", "journal": {"title": "Pediatrics", "issn": "1098-4275", "volume": "148", "issue": "3", "pages": "e2020042929", "issn-l": null}, "abstract": "To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children and adolescents diagnosed or hospitalized with coronavirus disease 2019 (COVID-19) and to compare them in secondary analyses with patients diagnosed with previous seasonal influenza in 2017-2018.\n\nInternational network cohort using real-world data from European primary care records (France, Germany, and Spain), South Korean claims and US claims, and hospital databases. We included children and adolescents diagnosed and/or hospitalized with COVID-19 at age <18 between January and June 2020. We described baseline demographics, comorbidities, symptoms, 30-day in-hospital treatments, and outcomes including hospitalization, pneumonia, acute respiratory distress syndrome, multisystem inflammatory syndrome in children, and death.\n\nA total of 242 158 children and adolescents diagnosed and 9769 hospitalized with COVID-19 and 2 084 180 diagnosed with influenza were studied. Comorbidities including neurodevelopmental disorders, heart disease, and cancer were more common among those hospitalized with versus diagnosed with COVID-19. Dyspnea, bronchiolitis, anosmia, and gastrointestinal symptoms were more common in COVID-19 than influenza. In-hospital prevalent treatments for COVID-19 included repurposed medications (<10%) and adjunctive therapies: systemic corticosteroids (6.8%-7.6%), famotidine (9.0%-28.1%), and antithrombotics such as aspirin (2.0%-21.4%), heparin (2.2%-18.1%), and enoxaparin (2.8%-14.8%). Hospitalization was observed in 0.3% to 1.3% of the cohort diagnosed with COVID-19, with undetectable (n < 5 per database) 30-day fatality. Thirty-day outcomes including pneumonia and hypoxemia were more frequent in COVID-19 than influenza.\n\nDespite negligible fatality, complications including hospitalization, hypoxemia, and pneumonia were more frequent in children and adolescents with COVID-19 than with influenza. Dyspnea, anosmia, and gastrointestinal symptoms could help differentiate diagnoses. A wide range of medications was used for the inpatient management of pediatric COVID-19.", "doi": "10.1542/peds.2020-042929", "pmid": "34049958", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "peds.2020-042929"}], "notes": [], "created": "2021-06-04T11:38:07.570Z", "modified": "2023-06-19T15:35:04.313Z"}, {"entity": "publication", "iuid": "5f6e4c6729a14595bd3010f6bcb6218f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f6e4c6729a14595bd3010f6bcb6218f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f6e4c6729a14595bd3010f6bcb6218f"}}, "title": "The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages", "authors": [{"family": "Martin", "given": "Darren P", "initials": "DP"}, {"family": "Weaver", "given": "Steven", "initials": "S", "orcid": "0000-0002-6931-7191", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b28e228830204c0787e6e291c5504314.json"}}, {"family": "Tegally", "given": "Houriiyah", "initials": "H"}, {"family": "San", "given": "James Emmanuel", "initials": "JE", "orcid": "0000-0002-5736-664X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5229990d46874a5185d136b09fce716a.json"}}, {"family": "Shank", "given": "Stephen D", "initials": "SD"}, {"family": "Wilkinson", "given": "Eduan", "initials": "E"}, {"family": "Lucaci", "given": "Alexander G", "initials": "AG"}, {"family": "Giandhari", "given": "Jennifer", "initials": "J"}, {"family": "Naidoo", "given": "Sureshnee", "initials": "S"}, {"family": "Pillay", "given": "Yeshnee", "initials": "Y"}, {"family": "Singh", "given": "Lavanya", "initials": "L", "orcid": "0000-0002-1726-4454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bbfb5df3bc34277aa004bfcf9a3775b.json"}}, {"family": "Lessells", "given": "Richard J", "initials": "RJ"}, {"family": "Gupta", "given": "Ravindra K", "initials": "RK"}, {"family": "Wertheim", "given": "Joel O", "initials": "JO"}, {"family": "Nekturenko", "given": "Anton", "initials": "A"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Harkins", "given": "Gordon W", "initials": "GW"}, {"family": "Lemey", "given": "Philippe", "initials": "P"}, {"family": "MacLean", "given": "Oscar A", "initials": "OA"}, {"family": "Robertson", "given": "David L", "initials": "DL"}, {"family": "de Oliveira", "given": "Tulio", "initials": "T", "orcid": "0000-0002-3027-5254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3dadcb78141a496ba76769d69667bf79.json"}}, {"family": "Kosakovsky Pond", "given": "Sergei L", "initials": "SL"}], "type": "journal-article", "published": "2021-09-00", "journal": {"title": "Cell", "issn": "0092-8674", "issn-l": null}, "abstract": "The independent emergence late in 2020 of the B.1.1.7, B.1.351, and P.1 lineages of SARS-CoV-2 prompted renewed concerns about the evolutionary capacity of this virus to overcome public health interventions and rising population immunity. Here, by examining patterns of synonymous and non-synonymous mutations that have accumulated in SARS-CoV-2 genomes since the pandemic began, we find that the emergence of these three \"501Y lineages\" coincided with a major global shift in the selective forces acting on various SARS-CoV-2 genes. Following their emergence, the adaptive evolution of 501Y lineage viruses has involved repeated selectively favored convergent mutations at 35 genome sites, mutations we refer to as the 501Y meta-signature. The ongoing convergence of viruses in many other lineages on this meta-signature suggests that it includes multiple mutation combinations capable of promoting the persistence of diverse SARS-CoV-2 lineages in the face of mounting host immune recognition.", "doi": "10.1016/j.cell.2021.09.003", "pmid": "34537136", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0092-8674(21)01050-3"}, {"db": "pmc", "key": "PMC8421097"}, {"db": "URL", "key": "https://doi.org/10.5281/zenodo.5149112", "description": "Initial release of SARS-CoV2 variation data"}, {"db": "URL", "key": "https://observablehq.com/@spond/n501y-clades@3752", "description": "Visualizing selection analysis results for evolution of the B.1.351 clade"}, {"db": "URL", "key": "https://observablehq.com/@spond/sc2-selection-trends", "description": "Frequency trends and selection detection of subsets of sites in SARS-CoV-2 genes"}, {"db": "URL", "key": "https://observablehq.com/@spond/sc2-temporal-selection-trends", "description": "Temporal evolution of selective pressures on SARS-CoV-2 genes"}, {"db": "URL", "key": "https://github.com/spond/SARS-CoV-2-clade-analysis", "description": "Collection of result files and underlying sequence alignments processed by the RASCL SARS-CoV-2 clade analysis pipeline"}], "notes": [], "created": "2021-09-20T16:58:24.660Z", "modified": "2021-10-15T07:50:25.330Z"}, {"entity": "publication", "iuid": "a95b2d52208f4df0b81429ca74ff612c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a95b2d52208f4df0b81429ca74ff612c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a95b2d52208f4df0b81429ca74ff612c"}}, "title": "Socioeconomic patterns and COVID-19 outcomes before, during and after the lockdown in Italy (2020).", "authors": [{"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Rosano", "given": "Aldo", "initials": "A"}, {"family": "Vescio", "given": "Maria Fenicia", "initials": "MF"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Regidor", "given": "Enrique", "initials": "E"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Health Place", "issn": "1873-2054", "issn-l": null, "volume": "71", "issue": null, "pages": "102642"}, "abstract": "The objective was to investigate the association between deprivation and COVID-19 outcomes in Italy during pre-lockdown, lockdown and post-lockdown periods using a retrospective cohort study with 38,534,169 citizens and 222,875 COVID-19 cases. Multilevel negative binomial regression models, adjusting for age, sex, population-density and region of residence were conducted to evaluate the association between area-level deprivation and COVID-19 incidence, case-hospitalisation rate and case-fatality. During lockdown and post-lockdown, but not during pre-lockdown, higher incidence of cases was observed in the most deprived municipalities compared with the least deprived ones. No differences in case-hospitalisation and case-fatality according to deprivation were observed in any period under study.", "doi": "10.1016/j.healthplace.2021.102642", "pmid": "34339938", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1353-8292(21)00138-6"}, {"db": "pmc", "key": "PMC8318679"}], "notes": [], "created": "2021-08-04T10:11:02.697Z", "modified": "2021-11-18T12:43:33.213Z"}, {"entity": "publication", "iuid": "cad7e895541f4af7a873cdfaf3742488", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cad7e895541f4af7a873cdfaf3742488.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cad7e895541f4af7a873cdfaf3742488"}}, "title": "Severe features during outbreak but low mortality observed immediately before and after a March-May 2020 COVID-19 outbreak in Stockholm, Sweden.", "authors": [{"family": "Pimenoff", "given": "Ville N", "initials": "VN"}, {"family": "Bj\u00f6rnstedt", "given": "Mikael", "initials": "M"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": "110", "issue": null, "pages": "433-435"}, "abstract": "The aim of this study was to estimate how well the excess mortality reflected the burden of coronavirus disease 2019 (COVID-19)-related deaths during the March-May 2020 COVID-19 outbreak in Stockholm, Sweden, and whether the excess mortality during the outbreak might have resulted in a compensatory reduced mortality after the outbreak.\n\nUsing previous 10-year or 5-year average mortality rates as a baseline, the excess mortality estimates before, during, and after the COVID-19 outbreak in March-May 2020 in Stockholm were compared.\n\nWeekly death estimates revealed that the immediate pre-outbreak and post-outbreak all-cause mortality did not exceed to excess mortality regardless of whether previous 10-year or 5-year average mortality was used. Forty-three days after the start of the outbreak, 74.4% of the total excess mortality was reportedly explained by known COVID-19-related deaths, and the present study reports an update, showing that 15 weeks after the start of the outbreak, the reported COVID-19-related deaths explained >99% of the total excess mortality.\n\nAn exceptional outbreak feature of rapid excess mortality was observed. However, no excess but similarly low mortality was observed immediately prior to the outbreak and post-outbreak, thus emphasizing the severity of the first wave of the COVID-19 outbreak in Stockholm.", "doi": "10.1016/j.ijid.2021.08.005", "pmid": "34375761", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)00637-8"}, {"db": "pmc", "key": "PMC8349439"}], "notes": [], "created": "2021-08-11T14:26:46.302Z", "modified": "2021-11-18T13:29:36.379Z"}, {"entity": "publication", "iuid": "b03b9a4143de4683b96849ba0bfa5111", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b03b9a4143de4683b96849ba0bfa5111.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b03b9a4143de4683b96849ba0bfa5111"}}, "title": "Risk of severe COVID-19 infection in International Space Station astronauts despite routine pre-mission measures.", "authors": [{"family": "Javad Mortazavi", "given": "Seyed Mohammad", "initials": "SM"}, {"family": "Mortazavi", "given": "Seyed Alireza", "initials": "SA"}, {"family": "Sihver", "given": "Lembit", "initials": "L"}], "type": "letter", "published": "2021-09-00", "journal": {"title": "J Allergy Clin Immunol Pract", "issn": "2213-2201", "volume": "9", "issue": "9", "pages": "3527", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jaip.2021.05.043", "pmid": "34507714", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-2198(21)00700-5"}], "notes": [], "created": "2021-09-13T06:26:57.018Z", "modified": "2021-09-13T06:26:57.029Z"}, {"entity": "publication", "iuid": "4695e8c834724f698d86079fff003688", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4695e8c834724f698d86079fff003688.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4695e8c834724f698d86079fff003688"}}, "title": "Rapid policy development for essential RMNCAH services in sub-Saharan Africa: what happened during the COVID-19 pandemic and what needs to happen going forward?", "authors": [{"family": "Waiswa", "given": "Peter", "initials": "P"}, {"family": "Wanduru", "given": "Phillip", "initials": "P", "orcid": "0000-0001-5934-2505", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/964f6d1176b747c7a00ea484da84d763.json"}}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "9", "issn-l": "2059-7908"}, "abstract": null, "doi": "10.1136/bmjgh-2021-006938", "pmid": "34526322", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-006938"}], "notes": [], "created": "2021-09-20T16:25:22.680Z", "modified": "2021-09-20T16:26:08.136Z"}, {"entity": "publication", "iuid": "5f788fe67f124e149aa2acc87db98309", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f788fe67f124e149aa2acc87db98309.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f788fe67f124e149aa2acc87db98309"}}, "title": "Prolonged Effects of the COVID-19 Pandemic on Sleep Medicine Services-Longitudinal Data from the Swedish Sleep Apnea Registry.", "authors": [{"family": "Grote", "given": "Ludger", "initials": "L"}, {"family": "Theorell-Hagl\u00f6w", "given": "Jenny", "initials": "J"}, {"family": "Ulander", "given": "Martin", "initials": "M"}, {"family": "Hedner", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Sleep Med Clin", "issn": "1556-4088", "volume": "16", "issue": "3", "pages": "409-416", "issn-l": null}, "abstract": "The worldwide COVID-19 pandemic has affected the operation of health care systems. The direct impact of obstructive sleep apnea (OSA) on COVID-19 infection outcome remains to be elucidated. However, the coincidence of common risk factors for OSA and severe COVID-19 suggests that patients with OSA receiving positive airway pressure therapy may have an advantage relative to those untreated when confronted with a COVID-19 infection. The ongoing COVID-19 pandemic has led to a substantial reduction of sleep medicine services, and the long-term consequences may be considerable. New strategies for the management of sleep disorders are needed to overcome the current underdiagnosis and delay of treatment.", "doi": "10.1016/j.jsmc.2021.05.008", "pmid": "34325820", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1556-407X(21)00037-0"}, {"db": "pmc", "key": "PMC8258548"}], "notes": [], "created": "2021-08-04T17:06:04.153Z", "modified": "2021-08-04T17:06:05.747Z"}, {"entity": "publication", "iuid": "24858b2248dd4d2fb059a4a6d3bbd9b7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24858b2248dd4d2fb059a4a6d3bbd9b7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24858b2248dd4d2fb059a4a6d3bbd9b7"}}, "title": "Persistent symptoms in Swedish children after hospitalisation due to COVID-19.", "authors": [{"family": "Sterky", "given": "Ellinor", "initials": "E", "orcid": "0000-0003-3375-133X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8391aeb720cb4ebba5786f3a36ea4412.json"}}, {"family": "Olsson-\u00c5kefeldt", "given": "Selma", "initials": "S", "orcid": "0000-0002-9429-4163", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cdc01b4c2be3486d93d3d7126f6bb78f.json"}}, {"family": "Hertting", "given": "Olof", "initials": "O", "orcid": "0000-0002-0813-7998", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2be33c918eb644a48c6e33d730b2482b.json"}}, {"family": "Herlenius", "given": "Eric", "initials": "E", "orcid": "0000-0002-6859-0620", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8435b38e1704191a54140c72dae0b42.json"}}, {"family": "Alfven", "given": "Tobias", "initials": "T", "orcid": "0000-0002-2328-3512", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3851560b984401780a380ab1262cd8b.json"}}, {"family": "Ryd Rinder", "given": "Malin", "initials": "M", "orcid": "0000-0002-2947-4117", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b87e79413e84d8bb0a71a16fa3975fc.json"}}, {"family": "Rhedin", "given": "Samuel", "initials": "S", "orcid": "0000-0001-5798-2875", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1ee9f85f72942ed94646ba9d15cede0.json"}}, {"family": "Hildenwall", "given": "Helena", "initials": "H", "orcid": "0000-0001-7570-9792", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b715a8b59a84c6fb25e72d6a43753e5.json"}}], "type": "letter", "published": "2021-09-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": "110", "issue": "9", "pages": "2578-2580"}, "abstract": "COVID-19 is generally mild in children1 and post-acute inflammatory conditions that are temporally associated with the virus are rare, but potentially severe. However, some children and adults experience persistent symptoms after COVID-19. 2 Long COVID has not been precisely defined, but one study reported symptoms approximately 60 days after the primary diagnosis.3 Although adult long COVID is increasingly being studied, the magnitude of persistent symptoms in children remains unclear.", "doi": "10.1111/apa.15999", "pmid": "34157167", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-28T17:56:03.366Z", "modified": "2021-08-16T14:23:57.296Z"}, {"entity": "publication", "iuid": "0349bf593ecb49c6bf12f56d3df2dc6f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0349bf593ecb49c6bf12f56d3df2dc6f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0349bf593ecb49c6bf12f56d3df2dc6f"}}, "title": "Online consultations in mental healthcare during the COVID-19 outbreak: An international survey study on professionals' motivations and perceived barriers.", "authors": [{"family": "De Witte", "given": "Nele A J", "initials": "NAJ"}, {"family": "Carlbring", "given": "Per", "initials": "P"}, {"family": "Etzelmueller", "given": "Anne", "initials": "A"}, {"family": "Nordgreen", "given": "Tine", "initials": "T"}, {"family": "Karekla", "given": "Maria", "initials": "M"}, {"family": "Haddouk", "given": "Lise", "initials": "L"}, {"family": "Belmont", "given": "Ang\u00e9lique", "initials": "A"}, {"family": "\u00d8verland", "given": "Svein", "initials": "S"}, {"family": "Abi-Habib", "given": "Rudy", "initials": "R"}, {"family": "Bernaerts", "given": "Sylvie", "initials": "S"}, {"family": "Brugnera", "given": "Agostino", "initials": "A"}, {"family": "Compare", "given": "Angelo", "initials": "A"}, {"family": "Duque", "given": "Aranzazu", "initials": "A"}, {"family": "Ebert", "given": "David Daniel", "initials": "DD"}, {"family": "Eimontas", "given": "Jonas", "initials": "J"}, {"family": "Kassianos", "given": "Angelos P", "initials": "AP"}, {"family": "Salgado", "given": "Jo\u00e3o", "initials": "J"}, {"family": "Schwerdtfeger", "given": "Andreas", "initials": "A"}, {"family": "Tohme", "given": "Pia", "initials": "P"}, {"family": "Van Assche", "given": "Eva", "initials": "E"}, {"family": "Van Daele", "given": "Tom", "initials": "T"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Internet Interv", "issn": "2214-7829", "issn-l": "2214-7829", "volume": "25", "issue": null, "pages": "100405"}, "abstract": "While the general uptake of e-mental health interventions remained low over the past years, physical distancing and lockdown measures relating to the COVID-19 pandemic created a need and demand for online consultations in only a matter of weeks.\r\n\r\nThis study investigates the uptake of online consultations provided by mental health professionals during lockdown measures in the first wave of the COVID-19 pandemic in the participating countries, with a specific focus on professionals' motivations and perceived barriers regarding online consultations.\r\n\r\nAn online survey on the use of online consultations was set up in March 2020. The Unified Theory of Acceptance and Use of Technology (UTAUT) guided the deductive qualitative analysis of the results.\r\n\r\nIn total, 2082 mental health professionals from Austria, Belgium, Cyprus, France, Germany, Italy, Lebanon, Lithuania, the Netherlands, Norway, Portugal, Spain, and Sweden were included. The results showed a high uptake of online consultations during the COVID-19 pandemic but limited previous training on this topic undergone by mental health professionals. Most professionals reported positive experiences with online consultations, but concerns about the performance of online consultations in a mental health context (e.g., in terms of relational aspects) and practical considerations (e.g., relating to privacy and security of software) appear to be major barriers that hinder implementation.\r\n\r\nThis study provides an overview of the mental health professionals' actual needs and concerns regarding the use of online consultations in order to highlight areas of possible intervention and allow the implementation of necessary governmental, educational, and instrumental support so that online consultations can become a feasible and stable option in mental healthcare.", "doi": "10.1016/j.invent.2021.100405", "pmid": "34401365", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2214-7829(21)00045-2"}, {"db": "pmc", "key": "PMC8350604"}], "notes": [], "created": "2021-08-18T07:32:00.562Z", "modified": "2021-11-18T13:57:18.398Z"}, {"entity": "publication", "iuid": "d3e60a40b96a49e48c21639c683b0aea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3e60a40b96a49e48c21639c683b0aea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3e60a40b96a49e48c21639c683b0aea"}}, "title": "Nordic responses to Covid-19: Governance and policy measures in the early phases of the pandemic", "authors": [{"family": "Saunes", "given": "Ingrid Sperre", "initials": "IS"}, {"family": "Vrangb\u00e6k", "given": "Karsten", "initials": "K"}, {"family": "Byrkjeflot", "given": "Haldor", "initials": "H"}, {"family": "Jervelund", "given": "Signe Smith", "initials": "SS"}, {"family": "Birk", "given": "Hans Okkels", "initials": "HO"}, {"family": "Tynkkynen", "given": "Liina Kaisa", "initials": "LK"}, {"family": "Keskim\u00e4ki", "given": "Ilmo", "initials": "I"}, {"family": "Sigurgeirsd\u00f3ttir", "given": "Sigurbj\u00f6rg", "initials": "S"}, {"family": "Janl\u00f6v", "given": "Nils", "initials": "N"}, {"family": "Ramsberg", "given": "Joakim", "initials": "J"}, {"family": "Hern\u00e1ndez-Quevedo", "given": "Cristina", "initials": "C"}, {"family": "Merkur", "given": "Sherry", "initials": "S"}, {"family": "Sagan", "given": "Anna", "initials": "A"}, {"family": "Karanikolos", "given": "Marina", "initials": "M"}], "type": "journal-article", "published": "2021-09-00", "journal": {"title": "Health Policy", "issn": "0168-8510", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/j.healthpol.2021.08.011", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:53:23.797Z", "modified": "2021-11-18T13:56:16.670Z"}, {"entity": "publication", "iuid": "3ffba70f864142d6b721bc583d93b2f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ffba70f864142d6b721bc583d93b2f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ffba70f864142d6b721bc583d93b2f9"}}, "title": "Lung transplant after 6 months on ECMO support for SARS-CoV-2-induced ARDS complicated by severe antibody-mediated rejection.", "authors": [{"family": "Lindstedt", "given": "Sandra", "initials": "S", "orcid": "0000-0003-4484-6473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0739b93800374fa789184d52aa753ffa.json"}}, {"family": "Grins", "given": "Edgar", "initials": "E"}, {"family": "Larsson", "given": "Hillevi", "initials": "H"}, {"family": "Nilsson", "given": "Johan", "initials": "J"}, {"family": "Akbarshahi", "given": "Hamid", "initials": "H"}, {"family": "Silva", "given": "Iran", "initials": "I"}, {"family": "Hyllen", "given": "Snejana", "initials": "S"}, {"family": "Wagner", "given": "Darcy", "initials": "D", "orcid": "0000-0003-3794-1309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a62680154e2e4ae2b7cec2c44af06c9a.json"}}, {"family": "Sj\u00f6gren", "given": "Johan", "initials": "J"}, {"family": "Hansson", "given": "Lennart", "initials": "L"}, {"family": "Ederoth", "given": "Per", "initials": "P"}, {"family": "Gustafsson", "given": "Ronny", "initials": "R"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "BMJ Open Respir Res", "issn": "2052-4439", "volume": "8", "issue": "1", "issn-l": null}, "abstract": "There have been a few reports of successful lung transplantation (LTx) in patients with SARS-CoV-2-induced acute respiratory distress syndrome (ARDS); however, all reports were with rather short follow-up. Here we present a 62-year-old man without prior lung diseases. Following SARS-CoV-2-induced ARDS and 6 months of extracorporeal membrane oxygenation, he underwent LTx. 3 months post-transplantation he developed acute hypoxia requiring emergency intubation. Chest imaging showed acute rejection, and de novo DQ8-DSA was discovered. He was treated with a high dose of corticosteroids and plasmapheresis and was extubated 4 days later, yet the de novo DQ8-DSA remained. After sessions of plasmapheresis and rituximab, the levels of de novo DQ8-DSA remained unchanged. Nine months post-transplantation the patient died of respiratory failure. We herein discuss the decision to transplant, the transplantation itself and the postoperative course with severe antibody-mediated rejection. In addition, we evaluated the histological changes of the explanted lungs and compared these with end-stage idiopathic pulmonary fibrosis tissue, where both similarities and differences are seen. With the current case experience, one might consider close monitoring regarding DSA, and gives further support that LTx should only be considered for very carefully selected patients.", "doi": "10.1136/bmjresp-2021-001036", "pmid": "34544734", "labels": {"Category: Health": null}, "xrefs": [{"db": "pii", "key": "8/1/e001036"}, {"db": "pmc", "key": "PMC8453592"}], "notes": [], "created": "2021-10-10T15:39:44.215Z", "modified": "2021-10-10T15:39:44.257Z"}, {"entity": "publication", "iuid": "9e954c97139b41d2b1149ef29da764ba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9e954c97139b41d2b1149ef29da764ba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9e954c97139b41d2b1149ef29da764ba"}}, "title": "Loop-Mediated Isothermal Amplification Detection of SARS-CoV-2 and Myriad Other Applications.", "authors": [{"family": "Moore", "given": "Keith J M", "initials": "KJM"}, {"family": "Cahill", "given": "Jeremy", "initials": "J"}, {"family": "Aidelberg", "given": "Guy", "initials": "G"}, {"family": "Aronoff", "given": "Rachel", "initials": "R"}, {"family": "Bekta\u015f", "given": "Ali", "initials": "A"}, {"family": "Bezdan", "given": "Daniela", "initials": "D"}, {"family": "Butler", "given": "Daniel J", "initials": "DJ"}, {"family": "Chittur", "given": "Sridar V", "initials": "SV"}, {"family": "Codyre", "given": "Martin", "initials": "M"}, {"family": "Federici", "given": "Fernan", "initials": "F"}, {"family": "Tanner", "given": "Nathan A", "initials": "NA"}, {"family": "Tighe", "given": "Scott W", "initials": "SW"}, {"family": "True", "given": "Randy", "initials": "R"}, {"family": "Ware", "given": "Sarah B", "initials": "SB"}, {"family": "Wyllie", "given": "Anne L", "initials": "AL"}, {"family": "Afshin", "given": "Evan E", "initials": "EE"}, {"family": "Bendesky", "given": "Andres", "initials": "A"}, {"family": "Chang", "given": "Connie B", "initials": "CB"}, {"family": "Dela Rosa", "given": "Richard", "initials": "R"}, {"family": "Elhaik", "given": "Eran", "initials": "E"}, {"family": "Erickson", "given": "David", "initials": "D"}, {"family": "Goldsborough", "given": "Andrew S", "initials": "AS"}, {"family": "Grills", "given": "George", "initials": "G"}, {"family": "Hadasch", "given": "Kathrin", "initials": "K"}, {"family": "Hayden", "given": "Andrew", "initials": "A"}, {"family": "Her", "given": "Seong-Young", "initials": "SY"}, {"family": "Karl", "given": "Julie A", "initials": "JA"}, {"family": "Kim", "given": "Chang Hee", "initials": "CH"}, {"family": "Kriegel", "given": "Alison J", "initials": "AJ"}, {"family": "Kunstman", "given": "Thomas", "initials": "T"}, {"family": "Landau", "given": "Zeph", "initials": "Z"}, {"family": "Land", "given": "Kevin", "initials": "K"}, {"family": "Langhorst", "given": "Bradley W", "initials": "BW"}, {"family": "Lindner", "given": "Ariel B", "initials": "AB"}, {"family": "Mayer", "given": "Benjamin E", "initials": "BE"}, {"family": "McLaughlin", "given": "Lee A", "initials": "LA"}, {"family": "McLaughlin", "given": "Matthew T", "initials": "MT"}, {"family": "Molloy", "given": "Jenny", "initials": "J"}, {"family": "Mozsary", "given": "Christopher", "initials": "C"}, {"family": "Nadler", "given": "Jerry L", "initials": "JL"}, {"family": "D'Silva", "given": "Melinee", "initials": "M"}, {"family": "Ng", "given": "David", "initials": "D"}, {"family": "O'Connor", "given": "David H", "initials": "DH"}, {"family": "Ongerth", "given": "Jerry E", "initials": "JE"}, {"family": "Osuolale", "given": "Olayinka", "initials": "O"}, {"family": "Pinharanda", "given": "Ana", "initials": "A"}, {"family": "Plenker", "given": "Dennis", "initials": "D"}, {"family": "Ranjan", "given": "Ravi", "initials": "R"}, {"family": "Rosbash", "given": "Michael", "initials": "M"}, {"family": "Rotem", "given": "Assaf", "initials": "A"}, {"family": "Segarra", "given": "Jacob", "initials": "J"}, {"family": "Sch\u00fcrer", "given": "Stephan", "initials": "S"}, {"family": "Sherrill-Mix", "given": "Scott", "initials": "S"}, {"family": "Solo-Gabriele", "given": "Helena", "initials": "H"}, {"family": "To", "given": "Shaina", "initials": "S"}, {"family": "Vogt", "given": "Merly C", "initials": "MC"}, {"family": "Yu", "given": "Albert D", "initials": "AD"}, {"family": "Mason", "given": "Christopher E", "initials": "CE"}, {"family": "gLAMP Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "J Biomol Tech", "issn": "1943-4731", "volume": "32", "issue": "3", "pages": "228-275", "issn-l": null}, "abstract": "As the second year of the COVID-19 pandemic begins, it remains clear that a massive increase in the ability to test for SARS-CoV-2 infections in a myriad of settings is critical to controlling the pandemic and to preparing for future outbreaks. The current gold standard for molecular diagnostics is the polymerase chain reaction (PCR), but the extraordinary and unmet demand for testing in a variety of environments means that both complementary and supplementary testing solutions are still needed. This review highlights the role that loop-mediated isothermal amplification (LAMP) has had in filling this global testing need, providing a faster and easier means of testing, and what it can do for future applications, pathogens, and the preparation for future outbreaks. This review describes the current state of the art for research of LAMP-based SARS-CoV-2 testing, as well as its implications for other pathogens and testing. The authors represent the global LAMP (gLAMP) Consortium, an international research collective, which has regularly met to share their experiences on LAMP deployment and best practices; sections are devoted to all aspects of LAMP testing, including preanalytic sample processing, target amplification, and amplicon detection, then the hardware and software required for deployment are discussed, and finally, a summary of the current regulatory landscape is provided. Included as well are a series of first-person accounts of LAMP method development and deployment. The final discussion section provides the reader with a distillation of the most validated testing methods and their paths to implementation. This review also aims to provide practical information and insight for a range of audiences: for a research audience, to help accelerate research through sharing of best practices; for an implementation audience, to help get testing up and running quickly; and for a public health, clinical, and policy audience, to help convey the breadth of the effect that LAMP methods have to offer.", "doi": "10.7171/jbt.21-3203-017", "pmid": "35136384", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8802757"}], "notes": [], "created": "2022-02-11T10:32:09.826Z", "modified": "2022-02-11T10:32:17.965Z"}, {"entity": "publication", "iuid": "85dcee06080e4aea9c86f5392da1999d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/85dcee06080e4aea9c86f5392da1999d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/85dcee06080e4aea9c86f5392da1999d"}}, "title": "Hepatitis C elimination in Sweden: Progress, challenges and opportunities for growth in the time of COVID-19.", "authors": [{"family": "Blach", "given": "Sarah", "initials": "S", "orcid": "0000-0002-9252-7576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25f4327805304f1fb1e3a1c656968937.json"}}, {"family": "Blom\u00e9", "given": "Marianne", "initials": "M"}, {"family": "Duberg", "given": "Ann-Sofi", "initials": "AS"}, {"family": "Jerkeman", "given": "Anna", "initials": "A"}, {"family": "K\u00e5berg", "given": "Martin", "initials": "M", "orcid": "0000-0001-6643-3245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/514db56665594916b97164f5084f7496.json"}}, {"family": "Klasa", "given": "Per-Erik", "initials": "PE"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Razavi-Shearer", "given": "Devin", "initials": "D", "orcid": "0000-0003-4135-1053", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d60126b540b49eb937bbb31d8ac45cb.json"}}, {"family": "Razavi", "given": "Homie", "initials": "H"}, {"family": "Aleman", "given": "Soo", "initials": "S", "orcid": "0000-0003-0461-4870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b0edb2db8d840989936f67047ce91de.json"}}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Liver Int", "issn": "1478-3231", "volume": "41", "issue": "9", "pages": "2024-2031", "issn-l": null}, "abstract": "In 2014, the burden of hepatitis C virus (HCV) in Sweden was evaluated, to establish a baseline and inform public health interventions. Considering the changing landscape of HCV treatment, prevention, and care, and in light of the COVID-19 pandemic, this analysis seeks to evaluate Sweden's progress towards the World Health Organization (WHO) elimination targets and identify remaining barriers.\n\nThe data used for modelling HCV transmission and disease burden in Sweden were obtained through literature review, unpublished sources and expert input. A dynamic Markov model was employed to forecast population sizes and incidence of HCV through 2030. Two scenarios ('2019 Base' and 'WHO Targets') were developed to evaluate Sweden's progress towards HCV elimination.\n\nAt the beginning of 2019, there were 29 700 (95% uncertainty interval: 19 300-33 700) viremic infections in Sweden. Under the base scenario, Sweden would achieve and exceed the WHO targets for diagnosis, treatment and liver-related death. However, new infections would decrease by less than 10%, relative to 2015. Achieving all WHO targets by 2030 would require (i) expanding harm reduction programmes to reach more than 90% of people who inject drugs (PWID) and (ii) treating 90% of HCV + PWID engaged in harm reduction programmes and \u22657% of PWID not involved in harm reduction programmes, annually by 2025.\n\nIt is of utmost importance that Sweden, and all countries, find sustainability in HCV programmes by broadening the setting and base of providers to provide stability and continuity of care during turbulent times.", "doi": "10.1111/liv.14978", "pmid": "34051065", "labels": {"Category: Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8242794"}], "notes": [], "created": "2023-01-13T14:46:38.274Z", "modified": "2023-01-13T14:46:48.471Z"}, {"entity": "publication", "iuid": "56cc843c98694345a065e7e0b108c56c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56cc843c98694345a065e7e0b108c56c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56cc843c98694345a065e7e0b108c56c"}}, "title": "Experiences and motives of retirement-aged workers during the first wave of COVID-19 in Slovenia: \"This was the first time in 40 years that I really saw spring\".", "authors": [{"family": "Bratun", "given": "Ur\u0161a", "initials": "U"}, {"family": "Asaba", "given": "Eric", "initials": "E"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "J Aging Stud", "issn": "1879-193X", "volume": "58", "pages": "100954", "issn-l": null}, "abstract": "Choosing to continue working after retirement eligibility can attract both negative and positive sentiments from the general public. Studies examining the motivations of older workers have so far been conducted in times of relative social and economic stability. However, little is known about what it means for older workers to work during a lockdown or pandemic situation. The present longitudinal study aimed to explore experiences of retirement-aged workers in Slovenia in relation to their motives for prolonged work activity amid the COVID-19 pandemic, using the theory of gerotranscendence as a theoretical framework. Nine workers were interviewed before and after the start of the pandemic. The qualitative analysis was based on 18 interviews and observations, juxtaposing two analytical methods in order to illustrate common themes across the data as well as tensions in specific situations within a narrative context. Four main themes are presented: Unchanged plans, Motive developments, Psychological preparation for retirement and Views of society. In addition, a narrative analysis is presented with a focus on self-transcending elements in some of the participants' narratives. The findings suggest that during a pandemic, older workers' individual experiences might be constructed more positively compared to other groups, especially if they develop agentic identity and pursue meaningful activities. We discuss an innovative approach to gerotranscendence, complementing this theory with concepts from occupational science to develop a clearer distinction from the now dated disengagement theory and examine the life trajectories of older workers in novel situations such as a pandemic.", "doi": "10.1016/j.jaging.2021.100954", "pmid": "34425986", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0890-4065(21)00044-X"}], "notes": [], "created": "2021-08-27T09:39:07.384Z", "modified": "2021-11-18T13:54:38.271Z"}, {"entity": "publication", "iuid": "deba1acb96974c1b9756c04ed740d482", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/deba1acb96974c1b9756c04ed740d482.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/deba1acb96974c1b9756c04ed740d482"}}, "title": "Essential Emergency and Critical Care: a consensus among global clinical experts.", "authors": [{"family": "Schell", "given": "Carl Otto", "initials": "CO", "orcid": "0000-0002-7904-1336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a40b337b45b471d97a102c355c9d874.json"}}, {"family": "Khalid", "given": "Karima", "initials": "K"}, {"family": "Wharton-Smith", "given": "Alexandra", "initials": "A", "orcid": "0000-0001-5335-2059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40347c37da324b1ab41667d9ecd71fd5.json"}}, {"family": "Oliwa", "given": "Jacquie", "initials": "J"}, {"family": "Sawe", "given": "Hendry R", "initials": "HR", "orcid": "0000-0002-0395-5385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b51230cf1724ae98dc3b0e3f438dcb1.json"}}, {"family": "Roy", "given": "Nobhojit", "initials": "N", "orcid": "0000-0003-2022-7416", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cfd30f7c54f481986b006f34ad4a541.json"}}, {"family": "Sanga", "given": "Alex", "initials": "A"}, {"family": "Marshall", "given": "John C", "initials": "JC", "orcid": "0000-0002-7902-6291", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4584172f0eb464caff9299d93cc2b71.json"}}, {"family": "Rylance", "given": "Jamie", "initials": "J"}, {"family": "Hanson", "given": "Claudia", "initials": "C", "orcid": "0000-0001-8066-7873", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c06a2e703c840788ccdf3b2c4c972bc.json"}}, {"family": "Kayambankadzanja", "given": "Raphael K", "initials": "RK"}, {"family": "Wallis", "given": "Lee A", "initials": "LA", "orcid": "0000-0003-2711-3139", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8564386ba3be49d3a3d8282952cfabf0.json"}}, {"family": "Jirwe", "given": "Maria", "initials": "M", "orcid": "0000-0003-4570-4047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b89bcaacee5b47c4bb55ecc43a5e07f0.json"}}, {"family": "Baker", "given": "Tim", "initials": "T", "orcid": "0000-0001-8727-7018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1454fc20049b4d47865268adf16d104a.json"}}, {"family": "EECC Collaborators", "given": "", "initials": ""}, {"family": "EECC Collaborators*", "given": "", "initials": ""}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "9", "issn-l": "2059-7908"}, "abstract": "Globally, critical illness results in millions of deaths every year. Although many of these deaths are potentially preventable, the basic, life-saving care of critically ill patients are often overlooked in health systems. Essential Emergency and Critical Care (EECC) has been devised as the care that should be provided to all critically ill patients in all hospitals in the world. EECC includes the effective care of low cost and low complexity for the identification and treatment of critically ill patients across all medical specialties. This study aimed to specify the content of EECC and additionally, given the surge of critical illness in the ongoing pandemic, the essential diagnosis-specific care for critically ill patients with COVID-19.\n\nIn a Delphi process, consensus (>90% agreement) was sought from a diverse panel of global clinical experts. The panel iteratively rated proposed treatments and actions based on previous guidelines and the WHO/ICRC's Basic Emergency Care. The output from the Delphi was adapted iteratively with specialist reviewers into a coherent and feasible package of clinical processes plus a list of hospital readiness requirements.\n\nThe 269 experts in the Delphi panel had clinical experience in different acute medical specialties from 59 countries and from all resource settings. The agreed EECC package contains 40 clinical processes and 67 requirements, plus additions specific for COVID-19.\n\nThe study has specified the content of care that should be provided to all critically ill patients. Implementing EECC could be an effective strategy for policy makers to reduce preventable deaths worldwide.", "doi": "10.1136/bmjgh-2021-006585", "pmid": "34548380", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-006585"}, {"db": "pmc", "key": "PMC8458367"}], "notes": [], "created": "2021-10-27T05:12:13.486Z", "modified": "2021-10-27T05:12:13.770Z"}, {"entity": "publication", "iuid": "81e107e78c0f4c01abbe63f378d1c489", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/81e107e78c0f4c01abbe63f378d1c489.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/81e107e78c0f4c01abbe63f378d1c489"}}, "title": "Early experience of COVID-19 vaccination in adults with systemic rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey.", "authors": [{"family": "Sattui", "given": "Sebastian Eduardo", "initials": "SE", "orcid": "0000-0002-3945-6828", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58eb263e05ae4014897c534b20631833.json"}}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Kennedy", "given": "Kevin", "initials": "K", "orcid": "0000-0001-8230-091X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e92ad85b0e843e3b11d71e87aa1edaf.json"}}, {"family": "Sirotich", "given": "Emily", "initials": "E", "orcid": "0000-0002-7087-8543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c5dfbc359844544aa3684d916185fac.json"}}, {"family": "Putman", "given": "Michael", "initials": "M"}, {"family": "Moni", "given": "Tarin T", "initials": "TT"}, {"family": "Akpabio", "given": "Akpabio", "initials": "A", "orcid": "0000-0002-4920-6494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a237df6d34e4f7da430d8d71bc73d45.json"}}, {"family": "Alp\u00edzar-Rodr\u00edguez", "given": "Deshir\u00e9", "initials": "D", "orcid": "0000-0002-6930-0517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44724489165b403d8cb39923240c7136.json"}}, {"family": "Berenbaum", "given": "Francis", "initials": "F", "orcid": "0000-0001-8252-7815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c14dfcd19e6a40e78373f28030d22b12.json"}}, {"family": "Bulina", "given": "Inita", "initials": "I"}, {"family": "Conway", "given": "Richard", "initials": "R", "orcid": "0000-0003-2538-3362", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77fe264e6d0d4c87b734f3fa02e42c15.json"}}, {"family": "Singh", "given": "Aman Dev", "initials": "AD"}, {"family": "Duff", "given": "Eimear", "initials": "E"}, {"family": "Durrant", "given": "Karen L", "initials": "KL"}, {"family": "Gheita", "given": "Tamer A", "initials": "TA"}, {"family": "Hill", "given": "Catherine L", "initials": "CL"}, {"family": "Howard", "given": "Richard A", "initials": "RA"}, {"family": "Hoyer", "given": "Bimba F", "initials": "BF"}, {"family": "Hsieh", "given": "Evelyn", "initials": "E"}, {"family": "El Kibbi", "given": "Lina", "initials": "L"}, {"family": "Kilian", "given": "Adam", "initials": "A"}, {"family": "Kim", "given": "Alfred Hyoungju", "initials": "AH", "orcid": "0000-0003-4074-0516", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5e89146ab5d45f8b436df9ff7e279e8.json"}}, {"family": "Liew", "given": "David F L", "initials": "DFL"}, {"family": "Lo", "given": "Chieh", "initials": "C"}, {"family": "Miller", "given": "Bruce", "initials": "B"}, {"family": "Mingolla", "given": "Serena", "initials": "S"}, {"family": "Nudel", "given": "Michal", "initials": "M"}, {"family": "Palmerlee", "given": "Candace A", "initials": "CA"}, {"family": "Singh", "given": "Jasvinder A", "initials": "JA", "orcid": "0000-0003-3485-0006", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e70577b3133946d097e7e21e739b8aec.json"}}, {"family": "Singh", "given": "Namrata", "initials": "N"}, {"family": "Ugarte-Gil", "given": "Manuel Francisco", "initials": "MF", "orcid": "0000-0003-1728-1999", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b49a52ac208747ed9b85f286119da620.json"}}, {"family": "Wallace", "given": "John", "initials": "J"}, {"family": "Young", "given": "Kristen J", "initials": "KJ"}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Costello", "given": "Wendy", "initials": "W"}, {"family": "Grainger", "given": "Rebecca", "initials": "R"}, {"family": "Machado", "given": "Pedro M", "initials": "PM", "orcid": "0000-0002-8411-7972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef40d1eea57946e4a37d2e92a02a47cd.json"}}, {"family": "Robinson", "given": "Philip C", "initials": "PC", "orcid": "0000-0002-3156-3418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/950b622d31724172817ccde09902d215.json"}}, {"family": "Sufka", "given": "Paul", "initials": "P"}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Yazdany", "given": "Jinoos", "initials": "J"}, {"family": "Harrison", "given": "Carly", "initials": "C"}, {"family": "Larch\u00e9", "given": "Maggie", "initials": "M"}, {"family": "Levine", "given": "Mitchell", "initials": "M"}, {"family": "Foster", "given": "Gary", "initials": "G"}, {"family": "Thabane", "given": "Lehana", "initials": "L"}, {"family": "Rider", "given": "Lisa G", "initials": "LG"}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS", "orcid": "0000-0003-0786-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d99dc166f48d4af7b8e46dc999c7444b.json"}}, {"family": "Simard", "given": "Julia F", "initials": "JF", "orcid": "0000-0001-5735-9856", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ac28a1c6150426997d458b40c43f512.json"}}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA", "orcid": "0000-0002-5556-4618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/192552e5e3d2435799e57111ea84502d.json"}}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "RMD Open", "issn": "2056-5933", "volume": "7", "issue": "3", "issn-l": null}, "abstract": "We describe the early experiences of adults with systemic rheumatic disease who received the COVID-19 vaccine.\n\nFrom 2 April to 30 April 2021, we conducted an online, international survey of adults with systemic rheumatic disease who received COVID-19 vaccination. We collected patient-reported data on clinician communication, beliefs and intent about discontinuing disease-modifying antirheumatic drugs (DMARDs) around the time of vaccination, and patient-reported adverse events after vaccination.\n\nWe analysed 2860 adults with systemic rheumatic diseases who received COVID-19 vaccination (mean age 55.3 years, 86.7% female, 86.3% white). Types of COVID-19 vaccines were Pfizer-BioNTech (53.2%), Oxford/AstraZeneca (22.6%), Moderna (21.3%), Janssen/Johnson & Johnson (1.7%) and others (1.2%). The most common rheumatic disease was rheumatoid arthritis (42.3%), and 81.2% of respondents were on a DMARD. The majority (81.9%) reported communicating with clinicians about vaccination. Most (66.9%) were willing to temporarily discontinue DMARDs to improve vaccine efficacy, although many (44.3%) were concerned about rheumatic disease flares. After vaccination, the most reported patient-reported adverse events were fatigue/somnolence (33.4%), headache (27.7%), muscle/joint pains (22.8%) and fever/chills (19.9%). Rheumatic disease flares that required medication changes occurred in 4.6%.\n\nAmong adults with systemic rheumatic disease who received COVID-19 vaccination, patient-reported adverse events were typical of those reported in the general population. Most patients were willing to temporarily discontinue DMARDs to improve vaccine efficacy. The relatively low frequency of rheumatic disease flare requiring medications was reassuring.", "doi": "10.1136/rmdopen-2021-001814", "pmid": "34493645", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "rmdopen-2021-001814"}], "notes": [], "created": "2021-09-09T05:41:15.198Z", "modified": "2021-09-09T05:42:15.542Z"}, {"entity": "publication", "iuid": "df2cb94bee5e4e78bdb2368bb1ad1e87", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/df2cb94bee5e4e78bdb2368bb1ad1e87.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/df2cb94bee5e4e78bdb2368bb1ad1e87"}}, "title": "Dismantling internet-based cognitive behavioral therapy for tinnitus. The contribution of applied relaxation: A randomized controlled trial.", "authors": [{"family": "Beukes", "given": "Eldr\u00e9 W", "initials": "EW"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Fagelson", "given": "Marc A", "initials": "MA"}, {"family": "Manchaiah", "given": "Vinaya", "initials": "V"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Internet Interv", "issn": "2214-7829", "volume": "25", "issue": null, "pages": "100402", "issn-l": "2214-7829"}, "abstract": "Internet-based cognitive behavioral therapy (ICBT) for tinnitus is an evidence-based intervention. The components of ICBT for tinnitus have, however, not been dismantled and thus the effectiveness of the different therapeutic components is unknown. It is, furthermore, not known if heterogeneous tinnitus subgroups respond differently to ICBT.\n\nThis dismantling study aimed to explore the contribution of applied relaxation within ICBT for reducing tinnitus distress and comorbidities associated with tinnitus. A secondary aim was to assess whether outcomes varied for three tinnitus subgroups, namely those with significant tinnitus severity, those with low tinnitus severity, and those with significant depression.\n\nA parallel randomized controlled trial design ( n = 126) was used to compare audiologist-guided applied relaxation with the full ICBT intervention. Recruitment was online and via the intervention platform. Assessments were completed at four-time points including a 2-month follow-up period. The primary outcome was tinnitus severity as measured by the Tinnitus Functional Index. Secondary outcomes were included for anxiety, depression, insomnia, negative tinnitus cognitions, health-related quality of life, hearing disability, and hyperacusis. Treatment engagement variables including the number of logins, number of modules opened, and the number of messages sent. Both an intention-to-treat analysis and completer's only analysis were undertaken.\n\nEngagement was low which compromised results as the full intervention was undertaken by few participants. Both the ICBT and applied relaxation resulted in large reduction of tinnitus severity (within-group effect sizes d = 0.87 and 0.68, respectively for completers only analysis), which were maintained, or further improved at follow-up. These reductions in tinnitus distress were greater for the ICBT group, with a small effect size differences (between-group d = 0.15 in favor of ICBT for completers only analysis). Tinnitus distress decreased the most at post-intervention for those with significant depression at baseline. Both ICBT and applied relaxation contributed to significant reductions on most secondary outcome measures, with no group differences, except for a greater reduction of hyperacusis in the ICBT group.\n\nDue to poor compliance partly attributed to the COVID-19 pandemic results were compromised. Further studies employing strategies to improve compliance and engagement are required. The intervention's effectiveness increased with initial level of tinnitus distress; those with the highest scores at intake experienced the most substantial changes on the outcome measures. This may suggest tailoring of interventions according to tinnitus severity. Larger samples are needed to confirm this.", "doi": "10.1016/j.invent.2021.100402", "pmid": "34040997", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2214-7829(21)00042-7"}, {"db": "pmc", "key": "PMC8141772"}, {"db": "URL", "key": "https://doi.org/10.6084/m9.figshare.13679179", "description": "Dataset, demographic questionnaire and metadata"}], "notes": [], "created": "2021-05-29T15:31:18.566Z", "modified": "2021-11-19T10:52:32.033Z"}, {"entity": "publication", "iuid": "7952fb75226c454491af5321fd3fa6a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7952fb75226c454491af5321fd3fa6a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7952fb75226c454491af5321fd3fa6a6"}}, "title": "Development of humoral and cellular immunological memory against SARS-CoV-2 despite B cell depleting treatment in multiple sclerosis", "authors": [{"family": "Asplund H\u00f6gelin", "given": "Klara", "initials": "K"}, {"family": "Ruffin", "given": "Nicolas", "initials": "N", "orcid": "0000-0002-3698-5505", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15efeb249ce44bb0ab2bc6017d2548d0.json"}}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Gafvelin", "given": "Guro", "initials": "G"}, {"family": "Gr\u00f6nlund", "given": "Hans", "initials": "H"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Khademi", "given": "Mohsen", "initials": "M"}, {"family": "Olsson", "given": "Tomas", "initials": "T"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Al Nimer", "given": "Faiez", "initials": "F"}], "type": "journal-article", "published": "2021-09-00", "journal": {"title": "iScience", "issn": "2589-0042", "issn-l": "2589-0042", "volume": "24", "issue": "9", "pages": "103078"}, "abstract": "B cell depleting therapies (BCDTs) are widely used as immunomodulating agents for autoimmune diseases such as multiple sclerosis. Their possible impact on development of immunity to severe acute respiratory syndrome virus-2 (SARS-CoV-2) has raised concerns with the coronavirus disease 2019 (COVID-19) pandemic. We here evaluated the frequency of COVID-19-like symptoms and determined immunological responses in participants of an observational trial comprising several multiple sclerosis disease modulatory drugs (COMBAT-MS; NCT03193866) and in eleven patients after vaccination, with a focus on BCDT. Almost all seropositive and 17.9% of seronegative patients on BCDT, enriched for a history of COVID-19-like symptoms, developed anti-SARS-CoV-2 T cell memory, and T cells displayed functional similarity to controls producing IFN-\u03b3 and TNF. Following vaccination, vaccine-specific humoral memory was impaired, while all patients developed a specific T cell response. These results indicate that BCDTs do not abrogate SARS-CoV-2 cellular memory and provide a possible explanation as to why the majority of patients on BCDTs recover from COVID-19.", "doi": "10.1016/j.isci.2021.103078", "pmid": "34490414", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Vaccine": null, "Research Area: High-throughput and high-content serology": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(21)01046-4"}, {"db": "pmc", "key": "PMC8410640"}], "notes": [], "created": "2021-09-09T05:36:02.573Z", "modified": "2021-12-13T08:58:20.658Z"}, {"entity": "publication", "iuid": "cedc0f4e7276462dbce1cf4d8fdf6cf0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cedc0f4e7276462dbce1cf4d8fdf6cf0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cedc0f4e7276462dbce1cf4d8fdf6cf0"}}, "title": "Conducting a multi-country online alcohol survey in the time of the COVID-19 pandemic: Opportunities and challenges.", "authors": [{"family": "Kilian", "given": "Carolin", "initials": "C", "orcid": "0000-0001-5913-6488", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed0409bb90b346cd9001bebb46bdcf87.json"}}, {"family": "Rehm", "given": "J\u00fcrgen", "initials": "J", "orcid": "0000-0001-5665-0385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83f5b8ddf5844eb6a1118d8ec4c4dca2.json"}}, {"family": "Allebeck", "given": "Peter", "initials": "P", "orcid": "0000-0002-2778-6467", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de9f0e1c3e4d402b93e61ad1c5a771fb.json"}}, {"family": "Bart\u00e1k", "given": "Miroslav", "initials": "M", "orcid": "0000-0002-7265-6514", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77e98268e4ef42f6a5a036b75d6a1c56.json"}}, {"family": "Braddick", "given": "Fleur", "initials": "F", "orcid": "0000-0001-6755-4567", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e9df2867269470ab43dd6802b5abb49.json"}}, {"family": "Gual", "given": "Antoni", "initials": "A", "orcid": "0000-0002-7130-981X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a9b53e2b8644056920e73b5b1d014d9.json"}}, {"family": "Matrai", "given": "Silvia", "initials": "S", "orcid": "0000-0002-0308-7354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/333166e20d4e4bf99ce09910268ab080.json"}}, {"family": "Petru\u017eelka", "given": "Benjamin", "initials": "B", "orcid": "0000-0003-0318-3589", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/135b991aff2a486cb76a4f362d85b5e6.json"}}, {"family": "Rogalewicz", "given": "Vladimir", "initials": "V", "orcid": "0000-0001-5432-4148", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/904dc3953e4e42d4ac5f317f7b3c5b36.json"}}, {"family": "Rossow", "given": "Ingeborg", "initials": "I", "orcid": "0000-0001-8652-9367", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab426c14c36143d0bd2da8eb86f74e97.json"}}, {"family": "Schulte", "given": "Bernd", "initials": "B", "orcid": "0000-0003-1139-030X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79c126298bdf42518d5d0384a7e1ec42.json"}}, {"family": "\u0160telem\u0117kas", "given": "Mindaugas", "initials": "M", "orcid": "0000-0002-2040-6900", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56ebd7e17fe04fd788add93ee5c3324d.json"}}, {"family": "Manthey", "given": "Jakob", "initials": "J", "orcid": "0000-0003-1231-3760", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5e779db5bf14c38aad0f3a964b7d9bd.json"}}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Int J Methods Psychiatr Res", "issn": "1557-0657", "issn-l": null, "volume": "30", "issue": "3", "pages": "e1875"}, "abstract": "This contribution provides insights into the methodology of a pan-European population-based online survey, performed without external funding during the COVID-19 pandemic. We present the impact of different dissemination strategies to collect data from a non-probabilistic convenience sample and outline post-stratification weighting schemes, to provide guidance for future multi-country survey studies.\n\nDescription and comparison of dissemination strategies for five exemplary countries (Czechia, Germany, Lithuania, Norway, Spain) participating in the Alcohol Use and COVID-19 Survey. Comparison of the sample distribution with the country's actual population distribution according to sociodemographics, and development of weighting schemes.\n\nThe dissemination of online surveys through national newspapers, paid social media adverts and dissemination with the support of national health ministries turned out to be the most effective strategies. Monitoring the responses and adapting dissemination strategies to reach under-represented groups, and the application of sample weights were helpful to achieve an analytic sample matching the respective general population profiles.\n\nReaching a large pan-European convenience sample, including most European countries, in a short time was feasible, with the support of a broad scientific network.", "doi": "10.1002/mpr.1875", "pmid": "33951258", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8209885"}, {"db": "figshare", "key": "10.6084/m9.figshare.13580693.v1"}], "notes": [], "created": "2021-05-06T05:52:12.283Z", "modified": "2023-06-19T07:33:03.794Z"}, {"entity": "publication", "iuid": "23272de6f88949138a758530f7ceb860", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23272de6f88949138a758530f7ceb860.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23272de6f88949138a758530f7ceb860"}}, "title": "Comparable endemic coronavirus nucleoprotein-specific antibodies in mild and severe Covid-19 patients.", "authors": [{"family": "Leach", "given": "Susannah", "initials": "S", "orcid": "0000-0002-9614-2753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18d00be831d241dca238b3253d1b45f6.json"}}, {"family": "Harandi", "given": "Ali M", "initials": "AM"}, {"family": "Bergstr\u00f6m", "given": "Tomas", "initials": "T"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "van der Hoek", "given": "Lia", "initials": "L"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "J Med Virol", "issn": "1096-9071", "issn-l": null, "volume": "93", "issue": "9", "pages": "5614-5617"}, "abstract": "The severity of disease of Covid-19 is highly variable, ranging from asymptomatic to critical respiratory disease and death. Potential cross-reactive immune responses between SARS-CoV-2 and endemic coronavirus (eCoV) may hypothetically contribute to this variability. We herein studied if eCoV nucleoprotein (N)-specific antibodies in the sera of patients with mild or severe Covid-19 are associated with Covid-19 severity. There were comparable levels of eCoV N-specific antibodies early and during the first month of infection in Covid-19 patients with mild and severe symptoms, and healthy SARS-CoV-2-negative subjects. These results warrant further studies to investigate the potential role of eCoV-specific antibodies in immunity to SARS-CoV-2 infection.", "doi": "10.1002/jmv.27038", "pmid": "33913546", "labels": {"Funder: Vinnova": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC8242474"}], "notes": [], "created": "2021-04-30T04:12:21.490Z", "modified": "2021-12-12T18:08:26.325Z"}, {"entity": "publication", "iuid": "d683d834f14e47f488d2376e7e0114ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d683d834f14e47f488d2376e7e0114ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d683d834f14e47f488d2376e7e0114ca"}}, "title": "COVID-19 and Its Triangle Effects on Human's Well-Being: a Qualitative Research Method Used to Collect Appropriate Data.", "authors": [{"family": "Fatahi", "given": "Nabi", "initials": "N"}, {"family": "Kakamad", "given": "Karwan", "initials": "K"}, {"family": "Babakr", "given": "Zana", "initials": "Z"}, {"family": "Tafran", "given": "Khaled", "initials": "K"}, {"family": "\u00d8kland", "given": "\u00d8yvind", "initials": "\u00d8"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Acta Inform Med", "issn": "0353-8109", "issn-l": null, "volume": "29", "issue": "3", "pages": "197-204"}, "abstract": "The health-related challenges caused by the virus and the implications of the policies implemented to fight against it further cause psychological and socio-economic consequences that could threaten the well-being of the people.\r\n\r\nThis study has been carried out to identify people's psychosoical reactions toward COVID-19.\r\n\r\nSemi-structured interviews as a qualitative research method were used to collect data from 20 people across three countries, and content analysis was applied to interpret the data.\r\n\r\nOverall, the results indicated that COVID-19 has had negative consequences on psychological well-being of the general population. COVID-19 has forced people to maintain social distance and has led to family conflicts in some families. Moreover, COVID-19 has caused loss of jobs and mental health problems.\r\n\r\nCOVID-19 has affected people's daily life and a significant influence on individuals and society. This research demonstrates some of the ramifications in terms of psychological well-being of the general population. One of the most important findings is the importance of social life and meeting people in person, not just online. The current pandemic is influencing people's psychological well-being in a variety of ways.", "doi": "10.5455/aim.2021.29.197-204", "pmid": "34759460", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "AIM-29-197"}, {"db": "pmc", "key": "PMC8563050"}], "notes": [], "created": "2021-11-26T15:17:35.417Z", "modified": "2022-11-23T08:52:38.642Z"}, {"entity": "publication", "iuid": "cd4149ce45ee4f1f899ff2e3efacc239", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd4149ce45ee4f1f899ff2e3efacc239.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd4149ce45ee4f1f899ff2e3efacc239"}}, "title": "Antiphospholipid antibodies and neurological manifestations in acute COVID-19: A single-centre cross-sectional study.", "authors": [{"family": "Benjamin", "given": "Laura A", "initials": "LA", "orcid": "0000-0002-9685-1664", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15ffcba9a1b94d2d9d33c533c03a23d5.json"}}, {"family": "Paterson", "given": "Ross W", "initials": "RW"}, {"family": "Moll", "given": "Rachel", "initials": "R"}, {"family": "Pericleous", "given": "Charis", "initials": "C"}, {"family": "Brown", "given": "Rachel", "initials": "R"}, {"family": "Mehta", "given": "Puja R", "initials": "PR"}, {"family": "Athauda", "given": "Dilan", "initials": "D"}, {"family": "Ziff", "given": "Oliver J", "initials": "OJ"}, {"family": "Heaney", "given": "Judith", "initials": "J"}, {"family": "Checkley", "given": "Anna M", "initials": "AM"}, {"family": "Houlihan", "given": "Catherine F", "initials": "CF"}, {"family": "Chou", "given": "Michael", "initials": "M"}, {"family": "Heslegrave", "given": "Amanda J", "initials": "AJ"}, {"family": "Chandratheva", "given": "Arvind", "initials": "A"}, {"family": "Michael", "given": "Benedict D", "initials": "BD"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Vivekanandam", "given": "Vinojini", "initials": "V"}, {"family": "Foulkes", "given": "Alexander", "initials": "A"}, {"family": "Mummery", "given": "Catherine J", "initials": "CJ"}, {"family": "Lunn", "given": "Michael P", "initials": "MP"}, {"family": "Keddie", "given": "Stephen", "initials": "S"}, {"family": "Spyer", "given": "Moira J", "initials": "MJ"}, {"family": "Mckinnon", "given": "Tom", "initials": "T"}, {"family": "Hart", "given": "Melanie", "initials": "M", "orcid": "0000-0002-7396-1916", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c6e01af5c6d4e5e8fed4f1404d1ad5c.json"}}, {"family": "Carletti", "given": "Francesco", "initials": "F"}, {"family": "J\u00e4ger", "given": "Hans Rolf", "initials": "HR"}, {"family": "Manji", "given": "Hadi", "initials": "H"}, {"family": "Zandi", "given": "Michael S", "initials": "MS"}, {"family": "Werring", "given": "David J", "initials": "DJ"}, {"family": "Nastouli", "given": "Eleni", "initials": "E"}, {"family": "Simister", "given": "Robert", "initials": "R"}, {"family": "Solomon", "given": "Tom", "initials": "T"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Schott", "given": "Jonathan M", "initials": "JM"}, {"family": "Cohen", "given": "Hannah", "initials": "H"}, {"family": "Efthymiou", "given": "Maria", "initials": "M"}, {"family": "UCLH Queen Square COVID-19 Biomarker Study group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "issn-l": null, "volume": "39", "issue": null, "pages": "101070"}, "abstract": "A high prevalence of antiphospholipid antibodies has been reported in case series of patients with neurological manifestations and COVID-19; however, the pathogenicity of antiphospholipid antibodies in COVID-19 neurology remains unclear.\n\nThis single-centre cross-sectional study included 106 adult patients: 30 hospitalised COVID-neurological cases, 47 non-neurological COVID-hospitalised controls, and 29 COVID-non-hospitalised controls, recruited between March and July 2020. We evaluated nine antiphospholipid antibodies: anticardiolipin antibodies [aCL] IgA, IgM, IgG; anti-beta-2 glycoprotein-1 [a\u03b22GPI] IgA, IgM, IgG; anti-phosphatidylserine/prothrombin [aPS/PT] IgM, IgG; and anti-domain I \u03b22GPI (aD1\u03b22GPI) IgG.\n\nThere was a high prevalence of antiphospholipid antibodies in the COVID-neurological (73.3%) and non-neurological COVID-hospitalised controls (76.6%) in contrast to the COVID-non-hospitalised controls (48.2%). aPS/PT IgG titres were significantly higher in the COVID-neurological group compared to both control groups (p < 0.001). Moderate-high titre of aPS/PT IgG was found in 2 out of 3 (67%) patients with acute disseminated encephalomyelitis [ADEM]. aPS/PT IgG titres negatively correlated with oxygen requirement (FiO2 R=-0.15 p = 0.040) and was associated with venous thromboembolism (p = 0.043). In contrast, aCL IgA (p < 0.001) and IgG (p < 0.001) was associated with non-neurological COVID-hospitalised controls compared to the other groups and correlated positively with d-dimer and creatinine but negatively with FiO2.\n\nOur findings show that aPS/PT IgG is associated with COVID-19-associated ADEM. In contrast, aCL IgA and IgG are seen much more frequently in non-neurological hospitalised patients with COVID-19. Characterisation of antiphospholipid antibody persistence and potential longitudinal clinical impact are required to guide appropriate management.\n\nThis work is supported by UCL Queen Square Biomedical Research Centre (BRC) and Moorfields BRC grants (#560441 and #557595). LB is supported by a Wellcome Trust Fellowship (222102/Z/20/Z). RWP is supported by an Alzheimer's Association Clinician Scientist Fellowship (AACSF-20-685780) and the UK Dementia Research Institute. KB is supported by the Swedish Research Council (#2017-00915) and the Swedish state under the agreement between the Swedish government and the County Councils, the ALF-agreement (#ALFGBG-715986). HZ is a Wallenberg Scholar supported by grants from the Swedish Research Council (#2018-02532), the European Research Council (#681712), Swedish State Support for Clinical Research (#ALFGBG-720931), the Alzheimer Drug Discovery Foundation (ADDF), USA (#201809-2016862), and theUK Dementia Research Institute at UCL. BDM is supported by grants from the MRC/UKRI (MR/V007181/1), MRC (MR/T028750/1) and Wellcome (ISSF201902/3). MSZ, MH and RS are supported by the UCL/UCLH NIHR Biomedical Research Centre and MSZ is supported by Queen Square National Brain Appeal.", "doi": "10.1016/j.eclinm.2021.101070", "pmid": "34401683", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC8358233"}, {"db": "pii", "key": "S2589-5370(21)00350-3"}], "notes": [], "created": "2021-08-18T07:31:21.399Z", "modified": "2023-06-19T14:53:11.303Z"}, {"entity": "publication", "iuid": "dea56f4dcd0c4470b38876ee38e5d449", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dea56f4dcd0c4470b38876ee38e5d449.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dea56f4dcd0c4470b38876ee38e5d449"}}, "title": "Prognostic Significance of Chest Imaging by LUS and CT in COVID-19 Inpatients: The ECOVID Multicenter Study.", "authors": [{"family": "Tana", "given": "Claudio", "initials": "C"}, {"family": "Ricci", "given": "Fabrizio", "initials": "F"}, {"family": "Coppola", "given": "Maria Gabriella", "initials": "MG"}, {"family": "Mantini", "given": "Cesare", "initials": "C"}, {"family": "Lauretani", "given": "Fulvio", "initials": "F"}, {"family": "Campanozzi", "given": "Daniele", "initials": "D"}, {"family": "Renda", "given": "Giulia", "initials": "G"}, {"family": "Gallina", "given": "Sabina", "initials": "S"}, {"family": "Lugar\u00e1", "given": "Marina", "initials": "M"}, {"family": "Cipollone", "given": "Francesco", "initials": "F"}, {"family": "Giamberardino", "given": "Maria Adele", "initials": "MA"}, {"family": "Mucci", "given": "Luciano", "initials": "L"}], "type": "journal article", "published": "2021-08-31", "journal": {"title": "Respiration", "issn": "1423-0356", "pages": "1-10", "issn-l": null}, "abstract": "Point-of-care lung ultrasound (LUS) score is a semiquantitative score of lung damage severity. High-resolution computed tomography (HRCT) is the gold standard method to evaluate the severity of lung involvement from the novel coronavirus disease (COVID-19). Few studies have investigated the clinical significance of LUS and HRCT scores in patients with COVID-19. Therefore, the aim of this study was to evaluate the prognostic yield of LUS and of HRCT in COVID-19 patients.\n\nWe carried out a multicenter, retrospective study aimed at evaluating the prognostic yield of LUS and HRCT by exploring the survival curve of COVID-19 inpatients. LUS and chest CT scores were calculated retrospectively by 2 radiologists with >10 years of experience in chest imaging, and the decisions were reached in consensus. LUS score was calculated on the basis of the presence or not of pleural line abnormalities, B-lines, and lung consolidations. The total score (range 0-36) was obtained from the sum of the highest scores obtained in each region. CT score was calculated for each of the 5 lobes considering the anatomical extension according to the percentage parenchymal involvement. The resulting overall global semiquantitative CT score was the sum of each single lobar score and ranged from 0 (no involvement) to 25 (maximum involvement).\n\nOne hundred fifty-three COVID-19 inpatients (mean age 65 \u00b1 15 years; 65% M), including 23 (15%) in-hospital deaths for any cause over a mean follow-up of 14 days were included. Mean LUS and CT scores were 19 \u00b1 12 and 10 \u00b1 7, respectively. A strong positive linear correlation between LUS and CT scores (Pearson correlation r = 0.754; R2 = 0.568; p < 0.001) was observed. By ROC curve analysis, the optimal cut-point for mortality prediction was 20 for LUS score and 4.5 for chest CT score. According to Kaplan-Meier survival analysis, in-hospital mortality significantly increased among COVID-19 patients presenting with an LUS score \u226520 (log-rank 0.003; HR 9.87, 95% CI: 2.22-43.83) or a chest CT score \u22654.5 (HR 4.34, 95% CI: 0.97-19.41). At multivariate Cox regression analysis, LUS score was the sole independent predictor of in-hospital mortality yielding an adjusted HR of 7.42 (95% CI: 1.59-34.5).\n\nLUS score is useful to stratify the risk in COVID-19 patients, predicting those that are at high risk of mortality.", "doi": "10.1159/000518516", "pmid": "34515247", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "000518516"}], "notes": [], "created": "2021-09-20T06:32:43.318Z", "modified": "2021-09-20T06:32:43.341Z"}, {"entity": "publication", "iuid": "7ca4e632c1764964a21e57705c6ff32a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7ca4e632c1764964a21e57705c6ff32a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7ca4e632c1764964a21e57705c6ff32a"}}, "title": "Negative effects of iodine-based contrast agent on renal function in patients with moderate reduced renal function hospitalized for COVID-19.", "authors": [{"family": "Kistner", "given": "Anna", "initials": "A", "orcid": "0000-0002-7942-3211", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/833e8a08aed54e66bf271a795f93507f.json"}}, {"family": "Tamm", "given": "Chen", "initials": "C"}, {"family": "Svensson", "given": "Ann Mari", "initials": "AM"}, {"family": "Beckman", "given": "Mats O", "initials": "MO"}, {"family": "Strand", "given": "Fredrik", "initials": "F"}, {"family": "Sk\u00f6ld", "given": "Magnus", "initials": "M"}, {"family": "Nyr\u00e9n", "given": "Sven", "initials": "S"}], "type": "journal article", "published": "2021-08-31", "journal": {"title": "BMC Nephrol", "issn": "1471-2369", "volume": "22", "issue": "1", "pages": "297", "issn-l": null}, "abstract": "Kidney disease and renal failure are associated with hospital deaths in patients with COVID - 19. We aimed to test if contrast enhancement affects short-term renal function in hospitalized COVID - 19 patients.\n\nPlasma creatinine (P-creatinine) was measured on the day of computed tomography (CT) and 24 h, 48 h, and 4-10 days after CT. Contrast-enhanced (n = 142) and unenhanced (n = 24) groups were subdivided, based on estimated glomerular filtration rates (eGFR), > 60 and \u2264 60 ml/min/1.73 m2. Contrast-induced acute renal failure (CI-AKI) was defined as \u226527 \u03bcmol/L increase or a > 50% rise in P-creatinine from CT or initiation of renal replacement therapy during follow-up. Patients with renal replacement therapy were studied separately. We evaluated factors associated with a > 50% rise in P-creatinine at 48 h and at 4-10 days after contrast-enhanced CT.\n\nMedian P-creatinine at 24-48 h and days 4-10 post-CT in patients with eGFR> 60 and eGFR\u226530-60 in contrast-enhanced and unenhanced groups did not differ from basal values. CI-AKI was observed at 48 h and at 4-10 days post contrast administration in 24 and 36% (n = 5/14) of patients with eGFR\u226530-60. Corresponding figures in the eGFR> 60 contrast-enhanced CT group were 5 and 5% respectively, (p < 0.037 and p < 0.001, Pearson \u03c72 test). In the former group, four of the five patients died within 30 days. Odds ratio analysis showed that an eGFR\u226530-60 and 30-day mortality were associated with CK-AKI both at 48 h and 4-10 days after contrast-enhanced CT.\n\nPatients with COVID - 19 and eGFR\u226530-60 had a high frequency of CK-AKI at 48 h and at 4-10 days after contrast administration, which was associated with increased 30-day mortality. For patients with eGFR\u226530-60, we recommend strict indications are practiced for contrast-enhanced CT. Contrast-enhanced CT had a modest effect in patients with eGFR> 60.", "doi": "10.1186/s12882-021-02469-w", "pmid": "34465289", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12882-021-02469-w"}, {"db": "pmc", "key": "PMC8407403"}], "notes": [], "created": "2021-09-06T06:21:51.895Z", "modified": "2021-09-06T06:21:51.945Z"}, {"entity": "publication", "iuid": "1a003c7f725c4e19aeee8cb678f456ed", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1a003c7f725c4e19aeee8cb678f456ed.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1a003c7f725c4e19aeee8cb678f456ed"}}, "title": "Intermarriage and COVID-19 mortality among immigrants. A population-based cohort study from Sweden.", "authors": [{"family": "Aradhya", "given": "Siddartha", "initials": "S", "orcid": "0000-0003-3748-6270", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07f9e1a0528249a7ba6d39e2c0f3a7fe.json"}}, {"family": "Brand\u00e9n", "given": "Maria", "initials": "M"}, {"family": "Drefahl", "given": "Sven", "initials": "S"}, {"family": "Obu\u0107ina", "given": "Ognjen", "initials": "O"}, {"family": "Andersson", "given": "Gunnar", "initials": "G"}, {"family": "Rostila", "given": "Mikael", "initials": "M"}, {"family": "Mussino", "given": "Eleonora", "initials": "E"}, {"family": "Ju\u00e1rez", "given": "Sol P\u00eda", "initials": "SP", "orcid": "0000-0001-9086-7588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7cb8065d45a4969857ebbc65d01a619.json"}}], "type": "journal article", "published": "2021-08-31", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "9", "pages": "e048952"}, "abstract": "To evaluate the role of language proficiency and institutional awareness in explaining excess COVID-19 mortality among immigrants.\n\nCohort study with follow-up between 12 March 2020 and 23 February 2021.\n\nSwedish register-based study on all residents in Sweden.\n\n3 963 356 Swedish residents in co-residential unions who were 30 years of age or older and alive on 12 March 2020 and living in Sweden in December 2019.\n\nCox regression models were conducted to assess the association between different constellations of immigrant-native couples (proxy for language proficiency and institutional awareness) and COVID-19 mortality and all other causes of deaths (2019 and 2020). Models were adjusted for relevant confounders.\n\nCompared with Swedish-Swedish couples (1.18 deaths per thousand person-years), both immigrants partnered with another immigrant and a native showed excess mortality for COVID-19 (HR 1.43; 95% CI 1.29 to 1.58 and HR 1.24; 95% CI 1.10 to 1.40, respectively), which translates to 1.37 and 1.28 deaths per thousand person-years. Moreover, similar results are found for natives partnered with an immigrant (HR 1.15; 95% CI 1.02 to 1.29), which translates to 1.29 deaths per thousand person-years. Further analysis shows that immigrants from both high-income and low-income and middle-income countries (LMIC) experience excess mortality also when partnered with a Swede. However, having a Swedish-born partner is only partially protective against COVID-19 mortality among immigrants from LMIC origins.\n\nLanguage barriers and/or poor institutional awareness are not major drivers for the excess mortality from COVID-19 among immigrants. Rather, our study provides suggestive evidence that excess mortality among immigrants is explained by differential exposure to the virus.", "doi": "10.1136/bmjopen-2021-048952", "pmid": "34465581", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8413476"}, {"db": "pii", "key": "bmjopen-2021-048952"}], "notes": [], "created": "2021-09-06T06:21:38.437Z", "modified": "2023-01-13T14:42:16.876Z"}, {"entity": "publication", "iuid": "edaa9c0fdc684b87a74e9042bf94b470", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/edaa9c0fdc684b87a74e9042bf94b470.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/edaa9c0fdc684b87a74e9042bf94b470"}}, "title": "Editorial: The Different Faces of Sickness.", "authors": [{"family": "Rademacher", "given": "Lena", "initials": "L"}, {"family": "Lasselin", "given": "Julie", "initials": "J"}, {"family": "Karshikoff", "given": "Bianka", "initials": "B"}, {"family": "Hundt", "given": "Jennifer E", "initials": "JE"}, {"family": "Engler", "given": "Harald", "initials": "H"}, {"family": "Lange", "given": "Tanja", "initials": "T"}], "type": "editorial", "published": "2021-08-31", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "735337", "issn-l": "1664-0640"}, "abstract": null, "doi": "10.3389/fpsyt.2021.735337", "pmid": "34531771", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8438174"}], "notes": [], "created": "2021-09-20T16:55:00.580Z", "modified": "2021-09-20T16:55:00.590Z"}, {"entity": "publication", "iuid": "02137f9a606f465db43e1cd4d73138d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02137f9a606f465db43e1cd4d73138d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02137f9a606f465db43e1cd4d73138d0"}}, "title": "Online teaching in physiotherapy education during COVID-19 pandemic in Italy: a retrospective case-control study on students' satisfaction and performance.", "authors": [{"family": "Rossettini", "given": "Giacomo", "initials": "G"}, {"family": "Geri", "given": "Tommaso", "initials": "T"}, {"family": "Turolla", "given": "Andrea", "initials": "A"}, {"family": "Viceconti", "given": "Antonello", "initials": "A"}, {"family": "Scum\u00e0", "given": "Cristina", "initials": "C"}, {"family": "Mirandola", "given": "Mattia", "initials": "M"}, {"family": "Dell'Isola", "given": "Andrea", "initials": "A"}, {"family": "Gianola", "given": "Silvia", "initials": "S"}, {"family": "Maselli", "given": "Filippo", "initials": "F"}, {"family": "Palese", "given": "Alvisa", "initials": "A"}], "type": "journal article", "published": "2021-08-30", "journal": {"title": "BMC Med Educ", "issn": "1472-6920", "volume": "21", "issue": "1", "pages": "456", "issn-l": null}, "abstract": "During COVID-19 pandemic, physiotherapy lecturers faced the challenge of rapidly shifting from face-to-face to online education. This retrospective case-control study aims to compare students' satisfaction and performances shown in an online course to a control group of students who underwent the same course delivered face-to-face in the previous five years.\n\nBetween March and April 2020, a class (n = 46) of entry-level physiotherapy students (University of Verona - Italy), trained by an experienced physiotherapist, had 24-hours online lessons. Students exposed to the same course in the previous five academic years (n = 112), delivered with face-to-face conventional lessons, served as a historical control. The course was organized in 3 sequential phases: (1) PowerPoint presentations were uploaded to the University online platform, (2) asynchronous video recorded lectures were provided on the same platform, and (3) between online lectures, the lecturer and students could communicate through an email chat to promote understanding, dispel any doubts and collect requests for supplementary material (e.g., scientific articles, videos, webinars, podcasts). Outcomes were: (1) satisfaction as routinely measured by University with a national instrument and populated in a database; (2) performance as measured with an oral examination.\n\nWe compared satisfaction with the course, expressed on a 5-point Likert scale, resulting in no differences between online and face-to-face teaching (Kruskal-Wallis 2 = 0.24, df = 1, p = 0.62). We weighted up students' results by comparing their mean performances with the mean performances of the same course delivered face-to-face in the previous five years, founding a statistical significance in favour of online teaching (Wilcoxon rank sum test W = 1665, p < 0.001).\n\nOnline teaching in entry-level Physiotherapy seems to be a feasible option to face COVID-19 pandemic, as satisfies students as well as face-to-face courses and leading to a similar performance. Entry-level Bachelors in Physiotherapy may consider moving to eLearning to facilitate access to higher education. Universities will have to train lecturers to help them develop appropriate pedagogical skills, and supply suitable support in terms of economic, organizational, and technological issues, aimed at guaranteeing a high level of education to their students.\n\nRetrospectively registered.", "doi": "10.1186/s12909-021-02896-1", "pmid": "34455979", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12909-021-02896-1"}], "notes": [], "created": "2021-09-01T07:44:05.171Z", "modified": "2021-09-01T07:44:05.184Z"}, {"entity": "publication", "iuid": "4bd928993ccb4b7b90cfbd024fc2beb7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4bd928993ccb4b7b90cfbd024fc2beb7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4bd928993ccb4b7b90cfbd024fc2beb7"}}, "title": "Knowledge, Attitude, Practice, and Fear of COVID-19: an Online-Based Cross-cultural Study.", "authors": [{"family": "Ali", "given": "Mohammad", "initials": "M", "orcid": "0000-0002-4685-5050", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7a7159c74bd4fe0b70772c0e38aca95.json"}}, {"family": "Uddin", "given": "Zakir", "initials": "Z", "orcid": "0000-0002-3018-0327", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4943eb54590d4da59a8e90294515693f.json"}}, {"family": "Banik", "given": "Palash Chandra", "initials": "PC", "orcid": "0000-0003-2395-9049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bc92afccb2642cdab232cc1ad2713b1.json"}}, {"family": "Hegazy", "given": "Fatma A", "initials": "FA", "orcid": "0000-0001-7457-083X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0821210ae124134ba4e59520be0ef83.json"}}, {"family": "Zaman", "given": "Shamita", "initials": "S"}, {"family": "Ambia", "given": "Abu Saleh Mohammed", "initials": "ASM"}, {"family": "Siddique", "given": "Md Kaoser Bin", "initials": "MKB", "orcid": "0000-0002-0336-2694", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1514c69edd242c8adf9a56020e10e53.json"}}, {"family": "Islam", "given": "Rezoana", "initials": "R"}, {"family": "Khanam", "given": "Fatema", "initials": "F"}, {"family": "Bahalul", "given": "Sayed Mohammad", "initials": "SM"}, {"family": "Sharker", "given": "Md Ahiduzzaman", "initials": "MA"}, {"family": "Hossain", "given": "FMAkram", "initials": "F"}, {"family": "Ahsan", "given": "Gias U", "initials": "GU", "orcid": "0000-0003-0737-5940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41c88cf1b358432a89fa4817902223f6.json"}}], "type": "journal article", "published": "2021-08-30", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "pages": "1-16", "issn-l": null}, "abstract": "The study aimed to measure Knowledge, Attitude, and Practice (KAP) and fear level towards COVID-19 and explore its cross-cultural variances in knowledge by sociodemographic factors among the general population of 8 different countries over 5 continents. It was a cross-sectional online survey. This survey was conducted in April 2020 among 1296 participants using the \"Google Form\" platform. Considering the social distancing formula and pandemic situation, we collect data using popular social media networks. Univariate and bivariate analyses were used to explore the collected data on KAP, fear, and sociodemographic factors. Overall knowledge score was 9.7 \u00b1 1.7 (out of 12), and gender differences (female vs male: 9.8 \u00b1 1.6 vs 9.5 \u00b1 1.9) were significant (p = 0.008) in the bivariate analysis. Knowledge score variances were found significant in some regions by gender, marital status, and education qualification. The highest and lowest mean knowledge scores were recorded in the Middle East (10.0 \u00b1 1.7) and Europe (9.3 \u00b1 2.0). Despite having a high fear score (22.5 \u00b1 5.6 out of 35), 78.35% of respondents were positively and 81.7% in a good practice level. Fear score rankings: Middle East (1st; 23.8 \u00b1 5.5), Europe (2nd; 23.2 \u00b1 5.8), Africa (3rd; 22.7 \u00b1 5.0), South Asia (4th; 22.1 \u00b1 5.7), Oceania (5th; 21.9 \u00b1 5.8), and North America (6th; 21.7 \u00b1 5.5). Fear and knowledge were not correlated. KAP and fear variation exist among geographical regions. Gender, marital status, and education qualification are factors in knowledge variances for some regions. KAP and fear measures can help health education programs consider some sociodemographic factors and regions during an outbreak of highly contagious disease and uplift a positive attitude and good practice.\n\nThe online version contains supplementary material available at 10.1007/s11469-021-00638-4.", "doi": "10.1007/s11469-021-00638-4", "pmid": "34483782", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "638"}, {"db": "pmc", "key": "PMC8404540"}], "notes": [], "created": "2021-09-08T06:25:42.911Z", "modified": "2021-11-18T13:50:53.704Z"}, {"entity": "publication", "iuid": "e25282f83df94d9aaffc0240d8b3982f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e25282f83df94d9aaffc0240d8b3982f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e25282f83df94d9aaffc0240d8b3982f"}}, "title": "Influenza Vaccination after Myocardial Infarction: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial.", "authors": [{"family": "Fr\u00f8bert", "given": "Ole", "initials": "O"}, {"family": "G\u00f6tberg", "given": "Matthias", "initials": "M"}, {"family": "Erlinge", "given": "David", "initials": "D"}, {"family": "Akhtar", "given": "Zubair", "initials": "Z"}, {"family": "Christiansen", "given": "Evald H", "initials": "EH"}, {"family": "MacIntyre", "given": "Chandini R", "initials": "CR"}, {"family": "Oldroyd", "given": "Keith G", "initials": "KG"}, {"family": "Motovska", "given": "Zuzana", "initials": "Z"}, {"family": "Erglis", "given": "Andrejs", "initials": "A"}, {"family": "Moer", "given": "Rasmus", "initials": "R"}, {"family": "Hlinomaz", "given": "Ota", "initials": "O"}, {"family": "Jakobsen", "given": "Lars", "initials": "L"}, {"family": "Engstr\u00f8m", "given": "Thomas", "initials": "T"}, {"family": "Jensen", "given": "Lisette O", "initials": "LO"}, {"family": "Fallesen", "given": "Christian O", "initials": "CO"}, {"family": "Jensen", "given": "Svend E", "initials": "SE"}, {"family": "Anger\u00e5s", "given": "Oskar", "initials": "O"}, {"family": "Calais", "given": "Fredrik", "initials": "F"}, {"family": "K\u00e5regren", "given": "Amra", "initials": "A"}, {"family": "Lauermann", "given": "J\u00f6rg", "initials": "J"}, {"family": "Mokhtari", "given": "Arash", "initials": "A"}, {"family": "Nilsson", "given": "Johan", "initials": "J"}, {"family": "Persson", "given": "Jonas", "initials": "J"}, {"family": "Stalby", "given": "Per", "initials": "P"}, {"family": "Islam", "given": "Abu K M M", "initials": "AKMM"}, {"family": "Rahman", "given": "Afzalur", "initials": "A"}, {"family": "Malik", "given": "Fazila", "initials": "F"}, {"family": "Choudhury", "given": "Sohel", "initials": "S"}, {"family": "Collier", "given": "Timothy", "initials": "T"}, {"family": "Pocock", "given": "Stuart J", "initials": "SJ"}, {"family": "Pernow", "given": "John", "initials": "J"}], "type": "journal article", "published": "2021-08-30", "journal": {"title": "Circulation", "issn": "1524-4539", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Background: Observational and small randomized studies suggest that influenza vaccine may reduce future cardiovascular events in patients with cardiovascular disease. Methods: We conducted an investigator-initiated, randomized, double-blind trial to compare inactivated influenza vaccine with saline placebo administered shortly after myocardial infarction (MI) (99.7% of patients) or high-risk stable coronary heart disease (0.3%). The primary endpoint was the composite of all-cause death, MI, or stent thrombosis at 12 months. A hierarchical testing strategy was used for the key secondary endpoints: all-cause death, cardiovascular death, MI, and stent thrombosis. Results: Due to the Covid-19 pandemic, the data safety and monitoring board decided to halt the trial before attaining the prespecified sample size. Between October 1, 2016, and March 1, 2020, 2571 participants were randomized at 30 centers across eight countries; 1290 assigned to influenza vaccine and 1281 to placebo. Over the 12-month follow-up, the primary outcome occurred in 67 participants (5.3%) assigned influenza vaccine and 91 participants (7.2%) assigned placebo (hazard ratio, 0.72; 95% confidence interval, 0.52 to 0.99; P=0.040). Rates of all-cause death were 2.9% and 4.9% (hazard ratio, 0.59; 0.39 to 0.89; P=0.010), of cardiovascular death 2.7% and 4.5%, (hazard ratio, 0.59; 0.39 to 0.90; P=0.014), and of MI 2.0% and 2.4% (hazard ratio, 0.86; 0.50 to 1.46, P=0.57) in the influenza vaccine and placebo groups, respectively. Conclusions: Influenza vaccination early after an MI or in high-risk coronary heart disease resulted in a lower risk of a composite of all-cause death, MI, or stent thrombosis, as well as a lower risk of all-cause death and cardiovascular death at 12 months compared with placebo. Clinical Trial Registration: URL: http://www.clinicaltrials.gov Unique identifier: NCT02831608.", "doi": "10.1161/CIRCULATIONAHA.121.057042", "pmid": "34459211", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT02831608"}], "notes": [], "created": "2021-09-06T15:50:59.276Z", "modified": "2021-09-06T15:51:55.770Z"}, {"entity": "publication", "iuid": "b8ae0a7929a94a8591dce0de9bd1a1bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8ae0a7929a94a8591dce0de9bd1a1bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8ae0a7929a94a8591dce0de9bd1a1bd"}}, "title": "Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopes.", "authors": [{"family": "Gattinger", "given": "Pia", "initials": "P"}, {"family": "Niespodziana", "given": "Katarzyna", "initials": "K"}, {"family": "Stiasny", "given": "Karin", "initials": "K"}, {"family": "Sahanic", "given": "Sabina", "initials": "S"}, {"family": "Tulaeva", "given": "Inna", "initials": "I"}, {"family": "Borochova", "given": "Kristina", "initials": "K"}, {"family": "Dorofeeva", "given": "Yulia", "initials": "Y"}, {"family": "Schlederer", "given": "Thomas", "initials": "T"}, {"family": "Sonnweber", "given": "Thomas", "initials": "T"}, {"family": "Hofer", "given": "Gerhard", "initials": "G"}, {"family": "Kiss", "given": "Renata", "initials": "R"}, {"family": "Kratzer", "given": "Bernhard", "initials": "B"}, {"family": "Trapin", "given": "Doris", "initials": "D"}, {"family": "Tauber", "given": "Peter A", "initials": "PA"}, {"family": "Rottal", "given": "Arno", "initials": "A"}, {"family": "K\u00f6rm\u00f6czi", "given": "Ulrike", "initials": "U"}, {"family": "Feichter", "given": "Melanie", "initials": "M"}, {"family": "Weber", "given": "Milena", "initials": "M"}, {"family": "Focke-Tejkl", "given": "Margarete", "initials": "M"}, {"family": "L\u00f6ffler-Ragg", "given": "Judith", "initials": "J"}, {"family": "M\u00fchl", "given": "Bernhard", "initials": "B"}, {"family": "Kropfm\u00fcller", "given": "Anna", "initials": "A"}, {"family": "Keller", "given": "Walter", "initials": "W"}, {"family": "Stolz", "given": "Frank", "initials": "F"}, {"family": "Henning", "given": "Rainer", "initials": "R"}, {"family": "Tancevski", "given": "Ivan", "initials": "I"}, {"family": "Puchhammer-St\u00f6ckl", "given": "Elisabeth", "initials": "E"}, {"family": "Pickl", "given": "Winfried F", "initials": "WF"}, {"family": "Valenta", "given": "Rudolf", "initials": "R"}], "type": "journal article", "published": "2021-08-28", "journal": {"title": "Allergy", "issn": "1398-9995", "issn-l": "0105-4538", "volume": null, "issue": null, "pages": null}, "abstract": "The determinants of successful humoral immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of critical importance for the design of effective vaccines and the evaluation of the degree of protective immunity conferred by exposure to the virus. As novel variants emerge, understanding their likelihood of suppression by population antibody repertoires has become increasingly important.\r\n\r\nIn this study we analysed the SARS-CoV-2 polyclonal antibody response in a large population of clinically well-characterized patients after mild and severe COVID-19 using a panel of microarrayed structurally folded and unfolded SARS-CoV-2 proteins, as well as sequential peptides, spanning the surface spike protein (S) and the receptor-binding domain (RBD) of the virus.\r\n\r\nS- and RBD-specific antibody responses were dominated by immunoglobulin G (IgG), mainly IgG1 , and directed against structurally folded S and RBD and three distinct peptide epitopes in S2. The virus-neutralization activity of patients\u00b4 sera was highly correlated with IgG antibodies specific for conformational but not sequential RBD epitopes and their ability to prevent RBD binding to its human receptor angiotensin-converting enzyme 2 (ACE2). Twenty percent of patients selectively lacked RBD-specific IgG. Only immunisation with folded, but not with unfolded RBD, induced antibodies against conformational epitopes with high virus-neutralizing activity. Conformational RBD epitopes required for protection do not seem to be altered in the currently emerging virus variants.\r\n\r\nThese results are fundamental for estimating the protective activity of antibody responses after natural infection or vaccination and for the design of vaccines, which can induce high levels of SARS-CoV-2-neutralizing antibodies conferring sterilizing immunity.", "doi": "10.1111/all.15066", "pmid": "34453317", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-09-01T07:34:03.895Z", "modified": "2021-09-01T07:35:00.011Z"}, {"entity": "publication", "iuid": "4720c066c4634d349e89e6e2482949e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4720c066c4634d349e89e6e2482949e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4720c066c4634d349e89e6e2482949e8"}}, "title": "Landscape of T-cell repertoires with public COVID-19-associated T-cell receptors in pre-pandemic risk cohorts.", "authors": [{"family": "Simnica", "given": "Donjete", "initials": "D", "orcid": "0000-0003-2286-1381", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ba6674f733f45a19f092396b7134252.json"}}, {"family": "Schulthei\u00df", "given": "Christoph", "initials": "C", "orcid": "0000-0001-9789-5776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88027bf0a4314e958d8bcf7016d8ddfc.json"}}, {"family": "Mohme", "given": "Malte", "initials": "M"}, {"family": "Paschold", "given": "Lisa", "initials": "L"}, {"family": "Willscher", "given": "Edith", "initials": "E"}, {"family": "Fitzek", "given": "Antonia", "initials": "A"}, {"family": "P\u00fcschel", "given": "Klaus", "initials": "K"}, {"family": "Matschke", "given": "Jakob", "initials": "J"}, {"family": "Ciesek", "given": "Sandra", "initials": "S"}, {"family": "Sedding", "given": "Daniel G", "initials": "DG"}, {"family": "Zhao", "given": "Yu", "initials": "Y", "orcid": "0000-0003-2632-7530", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c46abe67678044d88ed9313bb26819fe.json"}}, {"family": "Gagliani", "given": "Nicola", "initials": "N"}, {"family": "Maringer", "given": "Yacine", "initials": "Y"}, {"family": "Walz", "given": "Juliane S", "initials": "JS"}, {"family": "Heide", "given": "Janna", "initials": "J"}, {"family": "Schulze-Zur-Wiesch", "given": "Julian", "initials": "J"}, {"family": "Binder", "given": "Mascha", "initials": "M"}], "type": "journal article", "published": "2021-08-28", "journal": {"title": "Clin Transl Immunol", "issn": "2050-0068", "volume": "10", "issue": "9", "pages": "e1340", "issn-l": null}, "abstract": "T cells have an essential role in the antiviral defence. Public T-cell receptor (TCR) clonotypes are expanded in a substantial proportion of COVID-19 patients. We set out to exploit their potential use as read-out for COVID-19 T-cell immune responses.\n\nWe searched for COVID-19-associated T-cell clones with public TCRs, as defined by identical complementarity-determining region 3 (CDR3) beta chain amino acid sequence that can be reproducibly detected in the blood of COVID-19 patients. Of the different clonotype identification algorithms used in this study, deep sequencing of brain tissue of five patients with fatal COVID-19 delivered 68 TCR clonotypes with superior representation across 140 immune repertoires of unrelated COVID-19 patients.\n\nMining of immune repertoires from subjects not previously exposed to the virus showed that these clonotypes can be found in almost 20% of pre-pandemic immune repertoires of healthy subjects, with lower representation in repertoires from risk groups like individuals above the age of 60 years or patients with cancer.\n\nTogether, our data show that at least a proportion of the SARS-CoV-2 T-cell response is mediated by public TCRs that are present in repertoires of unexposed individuals. The lower representation of these clones in repertoires of risk groups or failure to expand such clones may contribute to more unfavorable clinical COVID-19 courses.", "doi": "10.1002/cti2.1340", "pmid": "34484739", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "CTI21340"}, {"db": "pmc", "key": "PMC8401425"}, {"db": "URL", "key": "https://gateway.ireceptor.org", "description": "AIRR-seq data (iReceptor Study ID IR-Binder-000001)"}, {"db": "URL", "key": "https://www.ebi.ac.uk/ena/browser/view/PRJEB38339?show=reads", "description": "Sequence data in ENA (Project: PRJEB38339)"}], "notes": [], "created": "2021-09-08T06:33:45.029Z", "modified": "2021-09-09T07:17:55.696Z"}, {"entity": "publication", "iuid": "527e3f4b97ac4d2b9894a63183be6e57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/527e3f4b97ac4d2b9894a63183be6e57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/527e3f4b97ac4d2b9894a63183be6e57"}}, "title": "\"We Thought We Were Prepared, but We Were Not\": Experiences from the Management of the Psychosocial Support Response during the COVID-19 Pandemic in Sweden. A Mixed-Methods Study.", "authors": [{"family": "Hugelius", "given": "Karin", "initials": "K", "orcid": "0000-0003-0534-4593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f7d4e9ff0f645598a2473e42806066a.json"}}, {"family": "Johansson", "given": "Sara", "initials": "S"}, {"family": "Sj\u00f6lin", "given": "Helena", "initials": "H"}], "type": "journal article", "published": "2021-08-28", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "17", "pages": null}, "abstract": "This study aimed to describe experiences of managing mental health and psychosocial activities during the first six months of the COVID-19 pandemic in Sweden. A national survey was answered by a non-probability sample of 340 involved in the psychosocial response. The psychosocial response operations met several challenges, mainly related to the diverse actors involved, lack of competence, and lack of preparations. Less than 20% of the participants had received specific training in the provision of psychosocial support during major incidents. The interventions used varied, and no large-scale interventions were used. The psychosocial response organizations were overwhelmed by the needs of health care staff and failed to meet the needs of patients and family members. An efficient and durable psychosocial response in a long-term crisis requires to be structured, planned and well-integrated into the overall pandemic response. All personnel involved need adequate and specific competence in evidence-based individual and large-scale interventions to provide psychosocial support in significant incidents. By increasing general awareness of mental wellbeing and psychosocial support amongst health professionals and their first-line managers, a more resilient health care system, both in everyday life and during major incidents and disasters, could be facilitated.", "doi": "10.3390/ijerph18179079", "pmid": "34501668", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph18179079"}], "notes": [], "created": "2021-09-13T06:08:21.348Z", "modified": "2021-11-18T13:49:38.010Z"}, {"entity": "publication", "iuid": "e707bb01f3554d2fa9ef5b495830bdad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e707bb01f3554d2fa9ef5b495830bdad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e707bb01f3554d2fa9ef5b495830bdad"}}, "title": "The clinical association between Periodontitis and COVID-19.", "authors": [{"family": "Gupta", "given": "Shipra", "initials": "S", "orcid": "0000-0003-2097-2459", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa6dd4cea3824827b3ead550b8267b2a.json"}}, {"family": "Mohindra", "given": "Ritin", "initials": "R"}, {"family": "Singla", "given": "Mohita", "initials": "M"}, {"family": "Khera", "given": "Sagar", "initials": "S"}, {"family": "Sahni", "given": "Vaibhav", "initials": "V"}, {"family": "Kanta", "given": "Poonam", "initials": "P"}, {"family": "Soni", "given": "Roop Kishor", "initials": "RK"}, {"family": "Kumar", "given": "Amit", "initials": "A"}, {"family": "Gauba", "given": "Krishan", "initials": "K"}, {"family": "Goyal", "given": "Kapil", "initials": "K"}, {"family": "Singh", "given": "Mini P", "initials": "MP"}, {"family": "Ghosh", "given": "Arnab", "initials": "A"}, {"family": "Kajal", "given": "Kamal", "initials": "K"}, {"family": "Mahajan", "given": "Varun", "initials": "V"}, {"family": "Bhalla", "given": "Ashish", "initials": "A"}, {"family": "Sorsa", "given": "Timo", "initials": "T"}, {"family": "R\u00e4is\u00e4nen", "given": "Ismo", "initials": "I"}], "type": "journal article", "published": "2021-08-27", "journal": {"title": "Clin Oral Investig", "issn": "1436-3771", "issn-l": null}, "abstract": "The study aimed to clinically assess the association between periodontitis and COVID-19-related outcomes.\n\nData pertaining to patient demographics, medical history, blood parameters, periodontal clinical examination and aMMP-8 point-of-care diagnostics (both site-level and patient-level) was recorded for eighty-two COVID-19-positive patients. COVID-19-related outcomes such as COVID-19 pneumonia, death/survival, types of hospital admission and need of assisted ventilation were also assessed.\n\nMales were predominantly afflicted with COVID-19, with advanced age exhibiting a greater association with the presence of periodontitis. Higher severity of periodontitis led to 7.45 odds of requiring assisted ventilation, 36.52 odds of hospital admission, 14.58 odds of being deceased and 4.42 odds of COVID-19-related pneumonia. The aMMP-8 mouthrinse kit was slightly more sensitive but less specific than aMMP-8 site-specific tests.\n\nBased on the findings of the present study, periodontitis seems to be related to poorer COVID-19-related outcomes. However, within the constraints of this work, a direct causality may not be established. Periodontitis, by means of skewing the systemic condition for a number of comorbidities, may eventually influence COVID-19 outcomes in an indirect manner.\n\nThe study is the first to clinically, and by means of a validated point-of-care diagnostic methodology, assess the association between periodontal health and COVID-19-related outcomes. Assessment of the periodontal status of individuals can aid in the identification of risk groups during the pandemic along with reinforcing the need to maintain oral hygiene and seeking periodontal care.", "doi": "10.1007/s00784-021-04111-3", "pmid": "34448073", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00784-021-04111-3"}, {"db": "pmc", "key": "PMC8390180"}], "notes": [], "created": "2021-09-01T07:29:31.641Z", "modified": "2021-09-01T07:29:31.688Z"}, {"entity": "publication", "iuid": "064027b6251c4ed792919419795510de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/064027b6251c4ed792919419795510de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/064027b6251c4ed792919419795510de"}}, "title": "SARS-CoV-2 Antibody Isotypes in Systemic Lupus Erythematosus Patients Prior to Vaccination: Associations With Disease Activity, Antinuclear Antibodies, and Immunomodulatory Drugs During the First Year of the Pandemic.", "authors": [{"family": "Sj\u00f6wall", "given": "Johanna", "initials": "J"}, {"family": "Azharuddin", "given": "Mohammad", "initials": "M"}, {"family": "Frodlund", "given": "Martina", "initials": "M"}, {"family": "Zhang", "given": "Yuming", "initials": "Y"}, {"family": "Sandner", "given": "Laura", "initials": "L"}, {"family": "Dahle", "given": "Charlotte", "initials": "C"}, {"family": "Hinkula", "given": "Jorma", "initials": "J"}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C"}], "type": "journal article", "published": "2021-08-27", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "12", "pages": "724047", "issn-l": "1664-3224"}, "abstract": "Impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic on individuals with arthritis has been highlighted whereas data on other rheumatic diseases, e.g., systemic lupus erythematosus (SLE), are scarce. Similarly to SLE, severe SARS-CoV-2 infection includes risks for thromboembolism, an unbalanced type I interferon response, and complement activation. Herein, SARS-CoV-2 antibodies in longitudinal samples collected prior to vaccination were analyzed and compared with SLE progression and antinuclear antibody (ANA) levels.\n\nOne hundred patients (83 women) with established SLE and a regular visit to the rheumatologist (March 2020 to January 2021) were included. All subjects donated blood and had done likewise prior to the pandemic. SARS-CoV-2 antibody isotypes (IgG, IgA, IgM) to the cell receptor-binding S1-spike outer envelope protein were detected by ELISA, and their neutralizing capacity was investigated. IgG-ANA were measured by multiplex technology.\n\nDuring the pandemic, 4% had PCR-confirmed infection but 36% showed SARS-CoV-2 antibodies of \u22651 isotype; IgA was the most common (30%), followed by IgM (9%) and IgG (8%). The antibodies had low neutralizing capacity and were detected also in prepandemic samples. Plasma albumin (p = 0.04) and anti-dsDNA (p = 0.003) levels were lower in patients with SARS-CoV-2 antibodies. Blood group, BMI, smoking habits, complement proteins, daily glucocorticoid dose, use of hydroxychloroquine, or self-reported coronavirus disease 2019 (COVID-19) symptoms (except fever, >38.5\u00b0C) did not associate with SARS-CoV-2 antibodies.\n\nOur data from early 2021 indicate that a large proportion of Swedish SLE patients had serological signs of exposure to SARS-CoV-2 but apparently with a minor impact on the SLE course. Use of steroids and hydroxychloroquine showed no distinct effects, and self-reported COVID-19-related symptoms correlated poorly with all antibody isotypes.", "doi": "10.3389/fimmu.2021.724047", "pmid": "34512651", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8430325"}], "notes": [], "created": "2021-09-20T06:34:23.895Z", "modified": "2023-06-19T15:35:17.591Z"}, {"entity": "publication", "iuid": "99548417cab34ceeb2290d9011bc64f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/99548417cab34ceeb2290d9011bc64f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/99548417cab34ceeb2290d9011bc64f4"}}, "title": "Post-traumatic stress disorder (PTSD) in parents of children with type 1 diabetes during Covid-19 pandemic.", "authors": [{"family": "Carducci", "given": "C", "initials": "C"}, {"family": "Rapini", "given": "N", "initials": "N"}, {"family": "Deodati", "given": "A", "initials": "A"}, {"family": "Pampanini", "given": "V", "initials": "V"}, {"family": "Cianfarani", "given": "S", "initials": "S"}, {"family": "Schiaffini", "given": "R", "initials": "R", "orcid": "0000-0002-9527-2353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5246b36ef614d9fb2ceb112e0cd80ba.json"}}], "type": "journal article", "published": "2021-08-26", "journal": {"title": "Ital J Pediatr", "issn": "1824-7288", "issn-l": null, "volume": "47", "issue": "1", "pages": "176"}, "abstract": "The Post-traumatic Stress Disorder (PTSD) is a group of persistent psychological and physiological symptoms due to a traumatic, severe, event. Only few studies focused on the effects of Covid-19 on psychosocial outcomes in children with Type 1 Diabetes (T1D) and their parents.\r\n\r\nThe aim of this study was to evaluate the presence PTSD in parents of children with T1D during COVID-19 pandemic lockdown.\r\n\r\nIn the period between March and May 2020 we submitted the \"Impact of Event Scale - Revised\" (IES-R) questionnaire to the parents of 34 children with Type 1 Diabetes, asking them to express their emotions about the ongoing Covid-19 pandemic.\r\n\r\nA total of thirty mothers (mean age 43.0 \u00b1 4.2 years) and 25 fathers (mean age 45.6 \u00b1 5.9 years) participated in the survey and completed the questionnaires. 29.1% of parents had a score that allows to define a clinically relevant level of PTSD; ten mothers and 6 fathers had a PTSD clinically relevant score, corresponding, respectively, to 28.4 and 24% of total mothers and fathers. Finally, mothers and fathers, both express PTSD symptoms mainly in the form of intrusion and hyperarousal.\r\n\r\nThe present study confirms a high prevalence symptoms related to PTSD in mothers and fathers of children with Type 1 Diabetes. We believe that psychosocial outcomes of the COVID-19 pandemic should be taken into account in the planning of the next future assistance for children with T1D.", "doi": "10.1186/s13052-021-01126-0", "pmid": "34446073", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13052-021-01126-0"}, {"db": "pmc", "key": "PMC8390018"}], "notes": [], "created": "2021-09-01T07:28:55.218Z", "modified": "2021-11-18T13:41:46.716Z"}, {"entity": "publication", "iuid": "47162541ac884a13b88bd4f57d46d617", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47162541ac884a13b88bd4f57d46d617.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47162541ac884a13b88bd4f57d46d617"}}, "title": "Evening-types show highest increase of sleep and mental health problems during the COVID-19 pandemic - Multinational study on 19,267 adults.", "authors": [{"family": "Merikanto", "given": "Ilona", "initials": "I", "orcid": "0000-0002-1222-6678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50ed32f3146e4c0aa13e934d46eeb4af.json"}}, {"family": "Kortesoja", "given": "Laura", "initials": "L"}, {"family": "Benedict", "given": "Christian", "initials": "C", "orcid": "0000-0002-8911-4068", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a61aee14ada46ce968c40c652ac72df.json"}}, {"family": "Chung", "given": "Frances", "initials": "F"}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J"}, {"family": "Espie", "given": "Colin A", "initials": "CA"}, {"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y", "orcid": "0000-0003-0683-6506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/630f66dea3ce4ff2afe3c46f7827355b.json"}}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L", "orcid": "0000-0003-3613-6631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e700e607f114414dba66aa366e3158b6.json"}}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK"}, {"family": "Chan", "given": "Ngan Yin", "initials": "NY"}, {"family": "Inoue", "given": "Yuichi", "initials": "Y"}, {"family": "Matsui", "given": "Kentaro", "initials": "K"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Plazzi", "given": "Giuseppe", "initials": "G"}, {"family": "Mota-Rolim", "given": "S\u00e9rgio Arthuro", "initials": "SA"}, {"family": "Leger", "given": "Damien", "initials": "D"}, {"family": "Penzel", "given": "Thomas", "initials": "T", "orcid": "0000-0002-4304-0112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0dc4e472c71460ab792f74bc8163a9a.json"}}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}], "type": "journal article", "published": "2021-08-25", "journal": {"issn": "1550-9109", "title": "Sleep", "issn-l": null}, "abstract": "Individual circadian type is a ubiquitous trait defining sleep, with eveningness often associated with poorer sleep and mental health than morningness. However, it is unknown whether COVID-19 pandemic has differentially affected sleep and mental health depending on the circadian type. Here, the differences in sleep and mental health between circadian types are examined globally before and during the COVID-19 pandemic.\n\nThe sample collected between May and August 2020 across 12 countries/regions consisted of 19,267 adults with information on their circadian type. Statistical analyses were performed by using Complex Sample procedures, stratified by country and weighted by the number of inhabitants in the country/area of interest and by the relative number of responders in that country/area.\n\nEvening-types had poorer mental health, well-being, and quality of life or health than other circadian types during the pandemic. Sleep-wake schedules were delayed especially on working days, and evening-types reported an increase in sleep duration. Sleep problems increased in all circadian types, but especially among evening-types, moderated by financial suffering and confinement. Intermediate-types were less vulnerable to sleep changes, although morningness protected from most sleep problems. These findings were confirmed after adjusting for age, sex, duration of the confinement or socio-economic status during the pandemic.\n\nThese findings indicate an alarming increase in sleep and mental health problems, especially among evening-types as compared to other circadian types during the pandemic.", "doi": "10.1093/sleep/zsab216", "pmid": "34432058", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6357297"}], "notes": [], "created": "2021-08-27T09:36:22.035Z", "modified": "2021-09-01T07:19:56.356Z"}, {"entity": "publication", "iuid": "70f55448c66a4a86b18adc2a11d6b260", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70f55448c66a4a86b18adc2a11d6b260.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70f55448c66a4a86b18adc2a11d6b260"}}, "title": "Testing indicators to monitor the COVID-19 pandemic.", "authors": [{"family": "Beaut\u00e9", "given": "Julien", "initials": "J"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "Spiteri", "given": "Gianfranco", "initials": "G"}], "type": "journal article", "published": "2021-08-24", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "issn-l": null}, "abstract": null, "doi": "10.1016/S1473-3099(21)00461-8", "pmid": "34450053", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(21)00461-8"}, {"db": "pmc", "key": "PMC8384351"}], "notes": [], "created": "2021-09-01T07:31:54.529Z", "modified": "2021-09-01T07:32:45.430Z"}, {"entity": "publication", "iuid": "7720ddb00d1f45708a974b7bb249483f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7720ddb00d1f45708a974b7bb249483f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7720ddb00d1f45708a974b7bb249483f"}}, "title": "Skin Exposures, Hand Eczema and Facial Skin Disease in Healthcare Workers During the COVID-19 Pandemic: A Cross-sectional Study.", "authors": [{"family": "Hamnerius", "given": "Nils", "initials": "N"}, {"family": "Pont\u00e9n", "given": "Ann", "initials": "A"}, {"family": "Bergendorff", "given": "Ola", "initials": "O"}, {"family": "Bruze", "given": "Magnus", "initials": "M"}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}, {"family": "Svedman", "given": "Cecilia", "initials": "C"}], "type": "journal article", "published": "2021-08-24", "journal": {"title": "Acta Derm Venereol", "issn": "1651-2057", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic has led to enhanced hygiene procedures and use of personal protective equipment, but also to increased attention to occupational skin disease in healthcare workers. The occurrence of hand and facial skin disease in > 5,000 Swedish healthcare workers was investigated in a questionnaire survey. Levels of skin exposure related to hygiene procedures and personal protective equipment were recorded. Caring for patients with COVID-19 entailed higher levels of wet work and face mask exposures, and was associated with higher 1-year prevalence of both hand eczema (36%) and facial skin disease (32%) compared with not being directly engaged in COVID-19 care (28% and 22%, respectively). Acne and eczema were the most common facial skin diseases; for both, a dose-dependent association with face mask use was found. Dose-dependent associations could be shown between hand eczema and exposure to soap and gloves, but not to alcohol-based hand disinfectants.", "doi": "10.2340/00015555-3904", "pmid": "34427318", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-27T09:37:42.140Z", "modified": "2021-09-01T07:23:18.951Z"}, {"entity": "publication", "iuid": "b1018af9509f47b19a78984fd97f69b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1018af9509f47b19a78984fd97f69b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1018af9509f47b19a78984fd97f69b2"}}, "title": "Editorial: Coronavirus Disease (COVID-19): The Impact and Role of Mass Media During the Pandemic.", "authors": [{"family": "Arriaga", "given": "Patr\u00edcia", "initials": "P"}, {"family": "Esteves", "given": "Francisco", "initials": "F"}, {"family": "Pavlova", "given": "Marina A", "initials": "MA"}, {"family": "Pi\u00e7arra", "given": "Nuno", "initials": "N"}], "type": "editorial", "published": "2021-08-23", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "729238", "issn-l": "1664-1078"}, "abstract": null, "doi": "10.3389/fpsyg.2021.729238", "pmid": "34497569", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8419265"}], "notes": [], "created": "2021-09-13T06:07:06.587Z", "modified": "2021-09-13T06:07:06.599Z"}, {"entity": "publication", "iuid": "63efea786d524e588aa3cca55dc76b1a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63efea786d524e588aa3cca55dc76b1a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63efea786d524e588aa3cca55dc76b1a"}}, "title": "Suicide by gender and 10-year age groups during the COVID-19 pandemic vs previous five years in Japan: An analysis of national vital statistics.", "authors": [{"family": "Eguchi", "given": "Akifumi", "initials": "A"}, {"family": "Nomura", "given": "Shuhei", "initials": "S"}, {"family": "Gilmour", "given": "Stuart", "initials": "S"}, {"family": "Harada", "given": "Nahoko", "initials": "N"}, {"family": "Sakamoto", "given": "Haruka", "initials": "H"}, {"family": "Ueda", "given": "Peter", "initials": "P"}, {"family": "Yoneoka", "given": "Daisuke", "initials": "D"}, {"family": "Tanoue", "given": "Yuta", "initials": "Y"}, {"family": "Kawashima", "given": "Takayuki", "initials": "T"}, {"family": "Hayashi", "given": "Takehiko I", "initials": "TI"}, {"family": "Arima", "given": "Yuzo", "initials": "Y"}, {"family": "Suzuki", "given": "Motoi", "initials": "M"}, {"family": "Hashizume", "given": "Masahiro", "initials": "M"}], "type": "journal article", "published": "2021-08-21", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "issn-l": null, "volume": "305", "issue": null, "pages": "114173"}, "abstract": "Using daily vital statistics data from the Japanese Ministry of Health, Labour and Welfare, we provide the first weekly and age-group-specific estimates of the additional suicide burden during the COVID-19 pandemic in Japan by gender, from January through November 2020. Our results indicate that compared with the previous five years, suicide cases in 2020 in Japan have increased from late July to November for women in all age groups and for men in the 20-29 and 80+ years age group. Targeted interventions based on age and gender might be more effective in reducing suicide during the COVID-19 pandemic in Japan.", "doi": "10.1016/j.psychres.2021.114173", "pmid": "34469804", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(21)00469-8"}], "notes": [], "created": "2021-09-06T06:18:57.351Z", "modified": "2022-11-23T08:53:26.049Z"}, {"entity": "publication", "iuid": "faf9cbc5033b47729c3640abd68177d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/faf9cbc5033b47729c3640abd68177d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/faf9cbc5033b47729c3640abd68177d9"}}, "title": "Internet-based stress recovery intervention FOREST for healthcare staff amid COVID-19 pandemic: study protocol for a randomized controlled trial.", "authors": [{"family": "Jovarauskaite", "given": "Lina", "initials": "L", "orcid": "0000-0002-8043-3003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d280b0d3947b4fb692053a571e4c593f.json"}}, {"family": "Dumarkaite", "given": "Austeja", "initials": "A"}, {"family": "Truskauskaite-Kuneviciene", "given": "Inga", "initials": "I"}, {"family": "Jovaisiene", "given": "Ieva", "initials": "I"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Kazlauskas", "given": "Evaldas", "initials": "E"}], "type": "clinical trial protocol", "published": "2021-08-21", "journal": {"title": "Trials", "issn": "1745-6215", "issn-l": null, "volume": "22", "issue": "1", "pages": "559"}, "abstract": "The demand for care during the COVID-19 pandemic has affected the mental health of healthcare workers (HCWs), thus increasing the need for psychosocial support services. Internet-based interventions have previously been found to reduce occupational stress. The study aims to test the effects of an Internet-based stress recovery intervention-FOREST-among HCWs.\r\n\r\nA randomized controlled trial (RCT) parallel group design with three measurement points will be conducted to assess the efficacy of an Internet-based stress recovery intervention FOREST for nurses. The FOREST intervention is a 6-week Internet-based CBT and mindfulness-based program which comprises of six modules: (1) Introduction, (2) Detachment (relaxation and sleep), (3) Distancing, (4) Mastery (challenge), (5) Control, and (6) Keeping the change alive. We will compare the intervention against a waiting list group at pre-test, post-test, and follow-up. Stress recovery, PTSD, complex PTSD, moral injury, the level of stress, depression, anxiety, and psychological well-being will be measured.\r\n\r\nThe study will contribute to the development of mental healthcare programs for the HCWs. Based on the outcomes of the study, the FOREST intervention can be further developed or offered to healthcare staff as a tool to cope with occupational stress.\r\n\r\nClinicalTrials.gov NCT04817995 . Registered on 30 March 2021.", "doi": "10.1186/s13063-021-05512-1", "pmid": "34419114", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13063-021-05512-1"}, {"db": "pmc", "key": "PMC8380103"}, {"db": "ClinicalTrials.gov", "key": "NCT04817995"}], "notes": [], "created": "2021-08-27T09:43:36.718Z", "modified": "2021-11-18T13:40:03.339Z"}, {"entity": "publication", "iuid": "21a5b0f2d8f14c15adaef521bb5ffb75", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/21a5b0f2d8f14c15adaef521bb5ffb75.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/21a5b0f2d8f14c15adaef521bb5ffb75"}}, "title": "A Global Survey of Emergency Department Responses to the COVID-19 Pandemic.", "authors": [{"family": "Mahajan", "given": "Prashant", "initials": "P"}, {"family": "Shu-Ling", "given": "Chong", "initials": "C"}, {"family": "Gutierrez", "given": "Camilo", "initials": "C"}, {"family": "White", "given": "Emily", "initials": "E"}, {"family": "Cher", "given": "Benjamin A Y", "initials": "BAY"}, {"family": "Freiheit", "given": "Elizabeth", "initials": "E"}, {"family": "Belle", "given": "Apoorva", "initials": "A"}, {"family": "EMERGE NETWORK", "given": "", "initials": ""}, {"family": "Kaartinen", "given": "Johanna", "initials": "J"}, {"family": "Kumar", "given": "Vijaya Arun", "initials": "VA"}, {"family": "Middleton", "given": "Paul M", "initials": "PM"}, {"family": "Ng", "given": "Chip Jin", "initials": "CJ"}, {"family": "Osei-Kwame", "given": "Daniel", "initials": "D"}, {"family": "Roth", "given": "Dominik", "initials": "D"}, {"family": "Sinja", "given": "Tej Prakash", "initials": "TP"}, {"family": "Galwankar", "given": "Sagar", "initials": "S"}, {"family": "Nypaver", "given": "Michele", "initials": "M"}, {"family": "Kuppermann", "given": "Nathan", "initials": "N"}, {"family": "EKelund", "given": "Ulf", "initials": "U"}], "type": "journal article", "published": "2021-08-21", "journal": {"title": "West J Emerg Med", "issn": "1936-9018", "volume": "22", "issue": "5", "pages": "1037-1044", "issn-l": null}, "abstract": "Emergency departments (ED) globally are addressing the coronavirus disease 2019 (COVID-19) pandemic with varying degrees of success. We leveraged the 17-country, Emergency Medicine Education & Research by Global Experts (EMERGE) network and non-EMERGE ED contacts to understand ED emergency preparedness and practices globally when combating the COVID-19 pandemic.\n\nWe electronically surveyed EMERGE and non-EMERGE EDs from April 3-June 1, 2020 on ED capacity, pandemic preparedness plans, triage methods, staffing, supplies, and communication practices. The survey was available in English, Mandarin Chinese, and Spanish to optimize participation. We analyzed survey responses using descriptive statistics.\n\n74/129 (57%) EDs from 28 countries in all six World Health Organization global regions responded. Most EDs were in Asia (49%), followed by North America (28%), and Europe (14%). Nearly all EDs (97%) developed and implemented protocols for screening, testing, and treating patients with suspected COVID-19 infections. Sixty percent responded that provider staffing/back-up plans were ineffective. Many sites (47/74, 64%) reported staff missing work due to possible illness with the highest provider proportion of COVID-19 exposures and infections among nurses.\n\nDespite having disaster plans in place, ED pandemic preparedness and response continue to be a challenge. Global emergency research networks are vital for generating and disseminating large-scale event data, which is particularly important during a pandemic.", "doi": "10.5811/westjem.2021.3.50358", "pmid": "34546878", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "westjem.2021.3.50358"}, {"db": "pmc", "key": "PMC8463065"}], "notes": [], "created": "2021-10-27T05:11:48.877Z", "modified": "2021-10-27T05:11:48.912Z"}, {"entity": "publication", "iuid": "6a507045616541839ab2f403d1f0b1f5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a507045616541839ab2f403d1f0b1f5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a507045616541839ab2f403d1f0b1f5"}}, "title": "Unexpected details regarding nosocomial transmission revealed by whole-genome sequencing of severe acute respiratory coronavirus virus 2 (SARS-CoV-2).", "authors": [{"family": "Myhrman", "given": "Sofia", "initials": "S", "orcid": "0000-0002-2954-1260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff2d7f2219e24cc39a96bb4e113b8e54.json"}}, {"family": "Olausson", "given": "Josefin", "initials": "J"}, {"family": "Ringlander", "given": "Johan", "initials": "J"}, {"family": "Gustavsson", "given": "Lin\u00e9a", "initials": "L"}, {"family": "Jakobsson", "given": "Hedvig E", "initials": "HE"}, {"family": "Sansone", "given": "Martina", "initials": "M"}, {"family": "Westin", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2021-08-20", "journal": {"title": "Infect Control Hosp Epidemiol", "issn": "1559-6834", "pages": "1-5", "issn-l": "0899-823X"}, "abstract": "Effective infection prevention and control (IPC) measures are key for protecting patients from nosocomial infections and require knowledge of transmission mechanisms in different settings. We performed a detailed outbreak analysis of the transmission and outcome of coronavirus disease 2019 (COVID-19) in a geriatric ward by combining whole-genome sequencing (WGS) with epidemiological data.\n\nRetrospective cohort study.\n\nTertiary-care hospital.\n\nPatients and healthcare workers (HCWs) from the ward with a nasopharyngeal sample (NPS) positive for severe acute respiratory coronavirus virus 2 (SARS-CoV-2) RNA during the outbreak period.\n\nPatient data regarding clinical characteristics, exposure and outcome were collected retrospectively from medical records. Stored NPSs from 32 patients and 15 HCWs were selected for WGS and phylogenetic analysis.\n\nThe median patient age was 84 years and 17 (53%) of 32 were male. Also, 14 patients (44%) died within 30 days of sampling. Viral loads were significantly higher among the deceased. WGS was successful in 28 (88%) of 32 patient samples and 14 (93%) of 15 HCW samples. Moreover, 3 separate viral clades were identified: 1 clade and 2 subclades among both patient and HCW samples. Integrated epidemiological and genetic analyses revealed 6 probable transmission events between patients and supported hospital-acquired COVID-19 among 25 of 32 patients.\n\nWGS provided an insight into the outbreak dynamics and true extent of nosocomial COVID-19. The extensive transmission between patients and HCWs indicated that current IPC measures were insufficient. We recommend increased use of WGS in outbreak investigations to identify otherwise unknown transmission links and to evaluate IPC measures.", "doi": "10.1017/ice.2021.374", "pmid": "34496989", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0899823X21003743"}], "notes": [], "created": "2021-09-13T06:06:19.296Z", "modified": "2021-09-13T06:06:19.338Z"}, {"entity": "publication", "iuid": "5c63ba50a60041fd80e0adc526bb1f27", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c63ba50a60041fd80e0adc526bb1f27.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c63ba50a60041fd80e0adc526bb1f27"}}, "title": "Axillary lymphadenopathy at the time of COVID-19 vaccination: ten recommendations from the European Society of Breast Imaging (EUSOBI).", "authors": [{"family": "Schiaffino", "given": "Simone", "initials": "S"}, {"family": "Pinker", "given": "Katja", "initials": "K"}, {"family": "Magni", "given": "Veronica", "initials": "V"}, {"family": "Cozzi", "given": "Andrea", "initials": "A"}, {"family": "Athanasiou", "given": "Alexandra", "initials": "A"}, {"family": "Baltzer", "given": "Pascal A T", "initials": "PAT"}, {"family": "Camps Herrero", "given": "Julia", "initials": "J"}, {"family": "Clauser", "given": "Paola", "initials": "P"}, {"family": "Fallenberg", "given": "Eva M", "initials": "EM"}, {"family": "Forrai", "given": "G\u00e1bor", "initials": "G"}, {"family": "Fuchsj\u00e4ger", "given": "Michael H", "initials": "MH"}, {"family": "Helbich", "given": "Thomas H", "initials": "TH"}, {"family": "Kilburn-Toppin", "given": "Fleur", "initials": "F"}, {"family": "Kuhl", "given": "Christiane K", "initials": "CK"}, {"family": "Lesaru", "given": "Mihai", "initials": "M"}, {"family": "Mann", "given": "Ritse M", "initials": "RM"}, {"family": "Panizza", "given": "Pietro", "initials": "P"}, {"family": "Pediconi", "given": "Federica", "initials": "F"}, {"family": "Pijnappel", "given": "Ruud M", "initials": "RM"}, {"family": "Sella", "given": "Tamar", "initials": "T"}, {"family": "Thomassin-Naggara", "given": "Isabelle", "initials": "I"}, {"family": "Zackrisson", "given": "Sophia", "initials": "S"}, {"family": "Gilbert", "given": "Fiona J", "initials": "FJ"}, {"family": "Sardanelli", "given": "Francesco", "initials": "F", "orcid": "0000-0001-6545-9427", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6ef97ff0f9b4b9b8b0c4396276bebe3.json"}}], "type": "journal article", "published": "2021-08-20", "journal": {"title": "Insights Imaging", "issn": "1869-4101", "volume": "12", "issue": "1", "pages": "119", "issn-l": null}, "abstract": "Unilateral axillary lymphadenopathy is a frequent mild side effect of COVID-19 vaccination. European Society of Breast Imaging (EUSOBI) proposes ten recommendations to standardise its management and reduce unnecessary additional imaging and invasive procedures: (1) in patients with previous history of breast cancer, vaccination should be performed in the contralateral arm or in the thigh; (2) collect vaccination data for all patients referred to breast imaging services, including patients undergoing breast cancer staging and follow-up imaging examinations; (3) perform breast imaging examinations preferentially before vaccination or at least 12 weeks after the last vaccine dose; (4) in patients with newly diagnosed breast cancer, apply standard imaging protocols regardless of vaccination status; (5) in any case of symptomatic or imaging-detected axillary lymphadenopathy before vaccination or at least 12 weeks after, examine with appropriate imaging the contralateral axilla and both breasts to exclude malignancy; (6) in case of axillary lymphadenopathy contralateral to the vaccination side, perform standard work-up; (7) in patients without breast cancer history and no suspicious breast imaging findings, lymphadenopathy only ipsilateral to the vaccination side within 12 weeks after vaccination can be considered benign or probably-benign, depending on clinical context; (8) in patients without breast cancer history, post-vaccination lymphadenopathy coupled with suspicious breast finding requires standard work-up, including biopsy when appropriate; (9) in patients with breast cancer history, interpret and manage post-vaccination lymphadenopathy considering the timeframe from vaccination and overall nodal metastatic risk; (10) complex or unclear cases should be managed by the multidisciplinary team.", "doi": "10.1186/s13244-021-01062-x", "pmid": "34417642", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13244-021-01062-x"}, {"db": "pmc", "key": "PMC8378785"}], "notes": [], "created": 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"https://publications-covid19.scilifelab.se/researcher/22f57b7602714f59bfbcc96a936d77a8.json"}}, {"family": "Bonfanti", "given": "Paolo", "initials": "P", "orcid": "0000-0001-7289-8823", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52b16f4f4f5c4031a8435f6f17e791c7.json"}}, {"family": "Biondi", "given": "Andrea", "initials": "A"}, {"family": "Tubiana", "given": "Sarah", "initials": "S", "orcid": "0000-0002-6526-6403", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c1b73b9bbe34e7b8f2b4acb82f9f438.json"}}, {"family": "Burdet", "given": "Charles", "initials": "C"}, {"family": "Nussbaum", "given": "Robert", "initials": "R", "orcid": "0000-0003-3445-8880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aabd2609b3e040328310c013efa546b2.json"}}, {"family": "Kahn-Kirby", "given": "Amanda", "initials": "A", "orcid": "0000-0002-8878-0413", "researcher": {"href": 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"researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ee6f7f1803e47de83ccf6f89964bce0.json"}}, {"family": "Puel", "given": "Anne", "initials": "A", "orcid": "0000-0003-2603-0323", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2bdac14a1d14b8496ffd12dac6df3e5.json"}}, {"family": "Boisson-Dupuis", "given": "St\u00e9phanie", "initials": "S", "orcid": "0000-0002-7115-116X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92c785f151bb490aa85764eb62c0508e.json"}}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "B\u00e9ziat", "given": "Vivien", "initials": "V", "orcid": "0000-0002-4020-824X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ec4013e8c1f41d3b3590231e846cfc6.json"}}, {"family": "Lifton", "given": "Richard P", "initials": "RP"}, {"family": "Bastard", "given": "Paul", "initials": "P", "orcid": "0000-0002-5926-8437", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e3388c840d04a25824530a9bf999f01.json"}}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD", "orcid": "0000-0002-8335-0262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3f0c0bf3c294622a95b062a5db4386d.json"}}, {"family": "Abel", "given": "Laurent", "initials": "L", "orcid": "0000-0001-7016-6493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fd6c4593c8c492a8dad8e49cb7a832a.json"}}, {"family": "Su", "given": "Helen C", "initials": "HC", "orcid": "0000-0002-5582-9110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad550813f03540d9a8240a3d96ad0829.json"}}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E", "orcid": "0000-0002-7358-9157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c50d261245743539a5813daffcaab72.json"}}, {"family": "Amara", "given": "Ali", "initials": "A"}, {"family": "Soumelis", "given": "Vassili", "initials": "V", "orcid": "0000-0003-1849-9834", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f213b2e1c984894b695760448e0f35b.json"}}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5369fe152ac94b5a81d4f913d85940a7.json"}}, {"family": "Zhang", "given": "Qian", "initials": "Q", "orcid": "0000-0002-9040-3289", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/341c0cb0fa7d41448e55344c82d68358.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL", "orcid": "0000-0002-7782-4169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1aca66ab7c39465faf2de03fa8a6722f.json"}}], "type": "journal article", "published": "2021-08-19", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "volume": "6", "issue": "62", "pages": "eabl4348", "issn-l": "2470-9468"}, "abstract": "Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare, biochemically deleterious X-linked TLR7 variants in 16 unrelated male individuals aged 7 to 71 years (mean: 36.7 years) from a cohort of 1,202 male patients aged 0.5 to 99 years (mean: 52.9 years) with unexplained critical COVID-19 pneumonia. None of the 331 asymptomatically or mildly infected male individuals aged 1.3 to 102 years (mean: 38.7 years) tested carry such TLR7 variants (p = 3.5 \u00d7 10-5). The phenotypes of five hemizygous relatives of index cases infected with SARS-CoV-2 include asymptomatic or mild infection (n=2, 5 and 38 years), or moderate (n=1, 5 years), severe (n=1, 27 years), or critical (n=1, 29 years) pneumonia. Two boys (aged 7 and 12 years) from a cohort of 262 male patients with severe COVID-19 pneumonia (mean: 51.0 years) are hemizygous for a deleterious TLR7 variant. The cumulative allele frequency for deleterious TLR7 variants in the male general population is < 6.5x10-4 We also show that blood B cell lines and myeloid cell subsets from the patients do not respond to TLR7 stimulation, a phenotype rescued by wild-type TLR7 The patients' blood plasmacytoid dendritic cells (pDCs) produce low levels of type I IFNs in response to SARS-CoV-2. Overall, X-linked recessive TLR7 deficiency is a highly penetrant genetic etiology of critical COVID-19 pneumonia, in about 1.8% of male patients below the age of 60 years. Human TLR7 and pDCs are essential for protective type I IFN immunity against SARS-CoV-2 in the respiratory tract.", "doi": "10.1126/sciimmunol.abl4348", "pmid": "34413140", "labels": {"Category: Proteins": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "mid", "key": "NIHMS1744435"}, {"db": "pmc", "key": "PMC8532080"}, {"db": "pii", "key": "6/62/eabl4348"}], "notes": [], "created": "2021-08-20T12:26:45.378Z", "modified": "2023-06-19T15:35:54.456Z"}, {"entity": "publication", "iuid": "7e0426156b054faf9b603d4ccb53cf7f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e0426156b054faf9b603d4ccb53cf7f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e0426156b054faf9b603d4ccb53cf7f"}}, "title": "Children's Expressions of Worry During the COVID-19 Pandemic in Sweden.", "authors": [{"family": "Sarkadi", "given": "Anna", "initials": "A"}, {"family": "Sahlin Torp", "given": "Lisa", "initials": "L"}, {"family": "P\u00e9rez-Aronsson", "given": "Anna", "initials": "A"}, {"family": "Warner", "given": "Georgina", "initials": "G", "orcid": "0000-0002-7850-9136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a44058151a6c4ff4be148921ad1e9e57.json"}}], "type": "journal article", "published": "2021-08-19", "journal": {"title": "J Pediatr Psychol", "issn": "1465-735X", "volume": "46", "issue": "8", "pages": "939-949", "issn-l": null}, "abstract": "Sweden is an international exception in its public health response to the COVID-19 pandemic, with a higher number of deaths, albeit not pediatric, compared with other Nordic countries. The objective of this study was to investigate what worries children and adolescents living in Sweden expressed in relation to the pandemic.\n\nUsing an anonymous web-survey, 1,047 children (4-12 years; N = 717) and adolescents (13-18 years; N = 330) responded to five background and four open-ended questions, one of which was: Is there anything that you are worried about when it comes to 'Corona'? The responses were coded using manifest content analysis. Interrater reliability was .95, assessed on the code level.\n\nWorry was common (77%); mostly (60%) related to disease or death of elderly relatives, parents, the child him/herself or general worry for the elderly/risk groups. Existential worry (15%) comprised worries about the future, including economy and worries about the world perishing or the contagion becoming uncontrollable. A developmental trajectory was evident in the nature of responses. Adolescents' worries about the future included missing out on their youth and employment. They also worried about society (6%), for example, the future of democracy and the world economy. There was no indication of socioeconomic status or geographic area (urban vs. rural) affecting the presence of worrisome thoughts.\n\nWorry about \"Corona\" was common. Universal preventative mental health intervention is warranted and could be conducted in the school setting. Intervention could be tailored by age, covering discussion on financial aspects with adolescents.", "doi": "10.1093/jpepsy/jsab060", "pmid": "34383921", "labels": {"Category: Public Health": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8376257"}, {"db": "pii", "key": "6349212"}], "notes": [], "created": "2023-01-13T13:42:08.183Z", "modified": "2023-01-13T13:42:08.229Z"}, {"entity": "publication", "iuid": "4a0182dcbd774f28879aa1e57743de3a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4a0182dcbd774f28879aa1e57743de3a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4a0182dcbd774f28879aa1e57743de3a"}}, "title": "Changes in Adolescents' Psychosocial Functioning and Well-Being as a Consequence of Long-Term COVID-19 Restrictions.", "authors": [{"family": "Kerekes", "given": "N\u00f3ra", "initials": "N", "orcid": "0000-0002-8854-0399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/175ef55a6f3b45909a0a76b55cc0e4b3.json"}}, {"family": "Bador", "given": "Kourosh", "initials": "K"}, {"family": "Sfendla", "given": "Anis", "initials": "A", "orcid": "0000-0001-7139-7058", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6f24957ee1054495b1e970210d5e1fb1.json"}}, {"family": "Belaatar", "given": "Mohjat", "initials": "M"}, {"family": "Mzadi", "given": "Abdennour El", "initials": "AE", "orcid": "0000-0002-0309-3586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d613682c3d36435c9bf4d0ec63d1c3fd.json"}}, {"family": "Jovic", "given": "Vladimir", "initials": "V"}, {"family": "Damjanovic", "given": "Rade", "initials": "R"}, {"family": "Erlandsson", "given": "Maria", "initials": "M"}, {"family": "Nguyen", "given": "Hang Thi Minh", "initials": "HTM"}, {"family": "Nguyen", "given": "Nguyet Thi Anh", "initials": "NTA"}, {"family": "Ulberg", "given": "Scott F", "initials": "SF"}, {"family": "Kuch-Cecconi", "given": "Rachael H", "initials": "RH"}, {"family": "Szombathyne Meszaros", "given": "Zsuzsa", "initials": "Z"}, {"family": "Stevanovic", "given": "Dejan", "initials": "D", "orcid": "0000-0001-8236-5246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fd2d9e3b1114cf5bd2a89e5ab0dc766.json"}}, {"family": "Senhaji", "given": "Meftaha", "initials": "M"}, {"family": "Hedman Ahlstr\u00f6m", "given": "Britt", "initials": "B"}, {"family": "Zouini", "given": "Btissame", "initials": "B", "orcid": "0000-0002-9692-2397", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8935bc90d78143139467d7cfe522f70a.json"}}], "type": "journal article", "published": "2021-08-19", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "16", "pages": null}, "abstract": "This work studied self-reports from adolescents on how the COVID-19 pandemic has changed their behaviors, relationships, mood, and victimization. Data collection was conducted between September 2020 and February 2021 in five countries (Sweden, the USA, Serbia, Morocco, and Vietnam). In total, 5114 high school students (aged 15 to 19 years, 61.8% females) responded to our electronic survey. A substantial proportion of students reported decreased time being outside (41.7%), meeting friends in real life (59.4%), and school performance (30.7%), while reporting increased time to do things they did not have time for before (49.3%) and using social media to stay connected (44.9%). One third of the adolescents increased exercise and felt that they have more control over their life. Only a small proportion of adolescents reported substance use, norm-breaking behaviors, or victimization. The overall COVID-19 impact on adolescent life was gender-specific: we found a stronger negative impact on female students. The results indicated that the majority of adolescents could adapt to the dramatic changes in their environment. However, healthcare institutions, municipalities, schools, and social services could benefit from the findings of this study in their work to meet the needs of those young people who signaled worsened psychosocial functioning, increased stress, and victimization.", "doi": "10.3390/ijerph18168755", "pmid": "34444502", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph18168755"}, {"db": "pmc", "key": "PMC8392883"}], "notes": [], "created": "2021-09-01T07:27:23.293Z", "modified": "2021-11-18T13:38:07.614Z"}, {"entity": "publication", "iuid": "1f6e2f184718454591ec16406ead3ed1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1f6e2f184718454591ec16406ead3ed1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1f6e2f184718454591ec16406ead3ed1"}}, "title": "Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.", "authors": [{"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Gervais", "given": "Adrian", "initials": "A"}, {"family": "Le Voyer", "given": "Tom", "initials": "T"}, {"family": "Rosain", "given": "J\u00e9r\u00e9mie", "initials": "J"}, {"family": "Philippot", "given": "Quentin", "initials": "Q"}, {"family": "Manry", "given": "J\u00e9r\u00e9my", "initials": "J"}, {"family": "Michailidis", "given": "Eleftherios", "initials": "E"}, {"family": "Hoffmann", "given": "Hans-Heinrich", "initials": "HH"}, {"family": "Eto", "given": "Shohei", "initials": "S"}, {"family": "Garcia-Prat", "given": "Marina", "initials": "M"}, {"family": "Bizien", "given": "Lucy", "initials": "L"}, {"family": "Parra-Mart\u00ednez", "given": "Alba", "initials": "A"}, {"family": "Yang", "given": "Rui", "initials": "R"}, {"family": "Haljasm\u00e4gi", "given": "Liis", "initials": "L"}, {"family": "Migaud", "given": "M\u00e9lanie", "initials": "M"}, {"family": "S\u00e4rekannu", "given": "Karita", "initials": "K"}, {"family": "Maslovskaja", "given": "Julia", "initials": "J"}, {"family": "de Prost", "given": "Nicolas", "initials": "N"}, {"family": "Tandjaoui-Lambiotte", "given": "Yacine", "initials": "Y"}, {"family": "Luyt", "given": "Charles-Edouard", "initials": "CE"}, {"family": "Amador-Borrero", "given": "Blanca", "initials": "B"}, {"family": "Gaudet", "given": "Alexandre", "initials": "A"}, {"family": "Poissy", "given": "Julien", "initials": "J"}, {"family": "Morel", "given": "Pascal", "initials": "P"}, {"family": "Richard", "given": "Pascale", "initials": "P"}, {"family": "Cognasse", "given": "Fabrice", "initials": "F"}, {"family": "Troya", "given": "Jesus", "initials": "J"}, {"family": "Trouillet-Assant", "given": "Sophie", "initials": "S"}, {"family": "Belot", "given": "Alexandre", "initials": "A"}, {"family": "Saker", "given": "Kahina", "initials": "K"}, {"family": "Gar\u00e7on", "given": "Pierre", "initials": "P"}, {"family": "Rivi\u00e8re", "given": "Jacques G", "initials": "JG"}, {"family": "Lagier", "given": "Jean-Christophe", "initials": "JC"}, {"family": "Gentile", "given": "St\u00e9phanie", "initials": "S"}, {"family": "Rosen", "given": "Lindsey B", "initials": "LB"}, {"family": "Shaw", "given": "Elana", "initials": "E"}, {"family": "Morio", "given": "Tomohiro", "initials": "T"}, {"family": "Tanaka", "given": "Junko", "initials": "J"}, {"family": "Dalmau", "given": "David", "initials": "D"}, {"family": "Tharaux", "given": "Pierre-Louis", "initials": "PL"}, {"family": "Sene", "given": "Damien", "initials": "D"}, {"family": "Stepanian", "given": "Alain", "initials": "A"}, {"family": "Megarbane", "given": "Bruno", "initials": "B"}, {"family": "Triantafyllia", "given": "Vasiliki", "initials": "V"}, {"family": "Fekkar", "given": "Arnaud", "initials": "A"}, {"family": "Heath", "given": "James R", "initials": "JR"}, {"family": "Franco", "given": "Jos\u00e9 Luis", "initials": "JL"}, {"family": "Anaya", 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{"family": "Arrestier", "given": "Romain", "initials": "R"}, {"family": "Boudhabhay", "given": "Idris", "initials": "I"}, {"family": "Baris-Feldman", "given": "Hagit", "initials": "H"}, {"family": "Hagin", "given": "David", "initials": "D"}, {"family": "Wauters", "given": "Joost", "initials": "J"}, {"family": "Meyts", "given": "Isabelle", "initials": "I"}, {"family": "Dyer", "given": "Adam H", "initials": "AH"}, {"family": "Kennelly", "given": "Sean P", "initials": "SP"}, {"family": "Bourke", "given": "Nollaig M", "initials": "NM"}, {"family": "Halwani", "given": "Rabih", "initials": "R"}, {"family": "Sharif-Askari", "given": "Narjes Saheb", "initials": "NS"}, {"family": "Dorgham", "given": "Karim", "initials": "K"}, {"family": "Sallette", "given": "J\u00e9rome", "initials": "J"}, {"family": "Sedkaoui", "given": "Souad Mehlal", "initials": "SM"}, {"family": "AlKhater", "given": "Suzan", "initials": "S"}, {"family": "Rigo-Bonnin", "given": "Ra\u00fal", "initials": "R"}, {"family": "Morandeira", "given": "Francisco", "initials": "F"}, {"family": "Roussel", "given": "Lucie", "initials": "L"}, {"family": "Vinh", "given": "Donald C", "initials": "DC"}, {"family": "Ostrowski", "given": "Sisse Rye", "initials": "SR"}, {"family": "Condino-Neto", "given": "Antonio", "initials": "A"}, {"family": "Prando", "given": "Carolina", "initials": "C"}, {"family": "Bonradenko", "given": "Anastasiia", "initials": "A"}, {"family": "Spaan", "given": "Andr\u00e1s N", "initials": "AN"}, {"family": "Gilardin", "given": "Laurent", "initials": "L"}, {"family": "Fellay", "given": "Jacques", "initials": "J"}, {"family": "Lyonnet", "given": "Stanislas", "initials": "S"}, {"family": "Bilguvar", "given": "Kaya", "initials": "K"}, {"family": "Lifton", "given": "Richard P", "initials": "RP"}, {"family": "Mane", "given": "Shrikant", "initials": "S"}, {"family": "HGID Lab", "given": "", "initials": ""}, {"family": "COVID Clinicians", "given": "", "initials": ""}, {"family": "COVID-STORM 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{"family": "3C-Dijon Study", "given": "", "initials": ""}, {"family": "Cerba Health-Care", "given": "", "initials": ""}, {"family": "Etablissement du Sang study group", "given": "", "initials": ""}, {"family": "Anderson", "given": "Mark S", "initials": "MS"}, {"family": "Boisson", "given": "Bertrand", "initials": "B"}, {"family": "B\u00e9ziat", "given": "Vivien", "initials": "V"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Vandreakos", "given": "Evangelos", "initials": "E"}, {"family": "Hermine", "given": "Olivier", "initials": "O"}, {"family": "Pujol", "given": "Aurora", "initials": "A"}, {"family": "Peterson", "given": "P\u00e4rt", "initials": "P"}, {"family": "Mogensen", "given": "Trine H", "initials": "TH"}, {"family": "Rowen", "given": "Lee", "initials": "L"}, {"family": "Mond", "given": "James", "initials": "J"}, {"family": "Debette", "given": "St\u00e9phanie", "initials": "S"}, {"family": "de Lamballerie", "given": "Xavier", "initials": "X"}, {"family": "Duval", "given": "Xavier", "initials": "X"}, {"family": "Mentr\u00e9", "given": "France", "initials": "F"}, {"family": "Zins", "given": "Marie", "initials": "M"}, {"family": "Soler-Palacin", "given": "Pere", "initials": "P"}, {"family": "Colobran", "given": "Roger", "initials": "R"}, {"family": "Gorochov", "given": "Guy", "initials": "G"}, {"family": "Solanich", "given": "Xavier", "initials": "X"}, {"family": "Susen", "given": "Sophie", "initials": "S"}, {"family": "Martinez-Picado", "given": "Javier", "initials": "J"}, {"family": "Raoult", "given": "Didier", "initials": "D"}, {"family": "Vasse", "given": "Marc", "initials": "M"}, {"family": "Gregersen", "given": "Peter K", "initials": "PK"}, {"family": "Piemonti", "given": "Lorenzo", "initials": "L"}, {"family": "Rodr\u00edguez-Gallego", "given": "Carlos", "initials": "C"}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD"}, {"family": "Su", "given": "Helen C", "initials": "HC"}, {"family": "Kisand", "given": "Kai", "initials": "K"}, {"family": "Okada", "given": "Satoshi", "initials": "S"}, {"family": "Puel", "given": "Anne", "initials": "A"}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E"}, {"family": "Rice", "given": "Charles M", "initials": "CM"}, {"family": "Tiberghien", "given": "Pierre", "initials": "P"}, {"family": "Zhang", "given": "Qian", "initials": "Q"}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A"}, {"family": "Abel", "given": "Laurent", "initials": "L"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL"}], "type": "journal article", "published": "2021-08-19", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "issn-l": "2470-9468", "volume": "6", "issue": "62", "pages": "eabl4340"}, "abstract": "Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-\u03b1 and/or -\u03c9 are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-\u03b1 and/or -\u03c9 (100 pg/mL, in 1/10 dilutions of plasma) in 13.6% of 3,595 patients with critical COVID-19, including 21% of 374 patients > 80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1,124 deceased patients (aged 20 days-99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-\u03b2. We also show, in a sample of 34,159 uninfected subjects from the general population, that auto-Abs neutralizing high concentrations of IFN-\u03b1 and/or -\u03c9 are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of subjects carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-\u03b2 do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over-80s, and total fatal COVID-19 cases.", "doi": "10.1126/sciimmunol.abl4340", "pmid": "34413139", "labels": {"Category: Proteins": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "mid", "key": "NIHMS1744468"}, {"db": "pmc", "key": "PMC8521484"}, {"db": "pii", "key": "6/62/eabl4340"}], "notes": [], "created": "2021-08-20T06:48:41.370Z", "modified": "2023-06-19T15:35:29.233Z"}, {"entity": "publication", "iuid": "7a67796ea81f41569b69fcc5d74102d3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a67796ea81f41569b69fcc5d74102d3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a67796ea81f41569b69fcc5d74102d3"}}, "title": "Two cases of severe COVID-19 in gestational week 27 and 28 respectively, after which both pregnancies proceeded to term.", "authors": [{"family": "\u00d6stling", "given": "H", "initials": "H"}, {"family": "Ugarph-Edfeldt", "given": "M", "initials": "M"}, {"family": "Hild\u00e9n", "given": "K", "initials": "K"}], "type": "case reports", "published": "2021-08-18", "journal": {"title": "Int J Obstet Anesth", "issn": "1532-3374", "volume": "48", "pages": "103212", "issn-l": null}, "abstract": "COVID-19 in pregnancy increases the risk of caesarean section. We present two cases of late gestation pregnant women with severe COVID-19. Both were successfully treated with mechanical ventilation without termination of pregnancy and, following recovery from COVID-19, had vaginal deliveries at term. These two cases demonstrate the possibility of treating pregnant women with severe COVID-19 with mechanical ventilation in the late second and early third trimesters without them having a pre-term delivery. With a multidisciplinary approach, such management could avoid the maternal risks of surgery during a severe infection and, at the same time, enable term birth with a lower risk of neonatal complications.", "doi": "10.1016/j.ijoa.2021.103212", "pmid": "34500190", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0959-289X(21)00270-3"}, {"db": "pmc", "key": "PMC8372455"}], "notes": [], "created": "2021-09-13T06:07:55.917Z", "modified": "2021-09-13T06:07:55.944Z"}, {"entity": "publication", "iuid": "30a815cc31754725934d9486c0e487ac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/30a815cc31754725934d9486c0e487ac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/30a815cc31754725934d9486c0e487ac"}}, "title": "Fear of COVID-19 and religious coping mediate the associations between religiosity and distress among older adults.", "authors": [{"family": "Asgari Ghoncheh", "given": "Karim", "initials": "K", "orcid": "0000-0003-0127-9480", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac0b0c26ed9246f4b4f4f75c80fce4da.json"}}, {"family": "Liu", "given": "Chieh-Hsiu", "initials": "CH"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Saffari", "given": "Mohsen", "initials": "M"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-08-18", "journal": {"title": "Health Promot Perspect", "issn": "2228-6497", "volume": "11", "issue": "3", "pages": "316-322", "issn-l": null}, "abstract": "Background: A mediation model was proposed to explain how religiosity, religious coping, and fear of coronavirus disease 2019 (COVID-19) explained anxiety and depression among older adults. Methods: With the use of a cross-sectional design, the Integrated Health System was used to randomly invite 1000 older adults residing in Qazvin to participate in an online survey. Within the period of November 2020 to January 2021, 696 older Iranian adults (mean age=69.56years; 57.9% women) agreed to participate in the study and reported demographic information as well as measures of religiosity, fear of COVID-19, religious coping, anxiety, and depression. Results: Religiosity had direct effects on depression (B [SE]=-0.087 [0.037]; P=0.023) but not anxiety (B [SE]=-0.063 [0.036]; P=0.072). Moreover, both fear of COVID-19 and religious coping significantly mediated the association between religiosity and anxiety (B [SE]=-0.360[0.035]; p=0.002) and that between religiosity and depression (B [SE]=-0.365 [0.034];P=0.002). Conclusion: During the tough time of COVID-19 pandemic, religiosity and religious coping were protectors for older adults in developing good mental. Therefore, future research is needed to examine education programs that are effective for older adults to obtain correct knowledge concerning COVID-19, including the protective COVID-19 infection behaviors. Therefore, older adults may reduce their fear via their enhanced correct knowledge concerning COVID-19.", "doi": "10.34172/hpp.2021.40", "pmid": "34660226", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8501474"}], "notes": [], "created": "2021-10-21T05:00:52.748Z", "modified": "2021-10-21T05:00:52.832Z"}, {"entity": "publication", "iuid": "7d7f3577978a4f85a174146b372fc4a5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d7f3577978a4f85a174146b372fc4a5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d7f3577978a4f85a174146b372fc4a5"}}, "title": "Southeast Asia is an emerging hotspot for COVID-19.", "authors": [{"family": "Chookajorn", "given": "Thanat", "initials": "T", "orcid": "0000-0003-2876-6203", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d23832ce2a8a4f1aaa4420c4beb68da3.json"}}, {"family": "Kochakarn", "given": "Theerarat", "initials": "T", "orcid": "0000-0002-3524-8079", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89f005dd677d4a118a343d260dd8a3ef.json"}}, {"family": "Wilasang", "given": "Chaiwat", "initials": "C"}, {"family": "Kotanan", "given": "Namfon", "initials": "N"}, {"family": "Modchang", "given": "Charin", "initials": "C"}], "type": "letter", "published": "2021-08-16", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956"}, "abstract": null, "doi": "10.1038/s41591-021-01471-x", "pmid": "34400842", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-021-01471-x"}], "notes": [], "created": "2021-08-18T07:32:32.235Z", "modified": "2021-08-18T07:32:32.304Z"}, {"entity": "publication", "iuid": "1148627e160a4b4c83b7700fd26ae64d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1148627e160a4b4c83b7700fd26ae64d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1148627e160a4b4c83b7700fd26ae64d"}}, "title": "No difference in biomarkers of ischemic heart injury and heart failure in patients with COVID-19 who received treatment with chloroquine phosphate and those who did not.", "authors": [{"family": "Beck-Friis", "given": "Josefine", "initials": "J", "orcid": "0000-0003-2400-4092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3f3764c8d95410abc83f9c3cca2eaeb.json"}}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Omerovic", "given": "Elmir", "initials": "E"}, {"family": "Zeijlon", "given": "Rickard", "initials": "R", "orcid": "0000-0001-6422-604X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ad7b579fe034ce0b8baf9c7b9209c4f.json"}}, {"family": "Gisslen", "given": "Magnus", "initials": "M"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}], "type": "journal article", "published": "2021-08-16", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "8", "pages": "e0256035"}, "abstract": "Chloroquine was promoted as a COVID-19 therapeutic early in the pandemic. Most countries have since discontinued the use of chloroquine due to lack of evidence of any benefit and the risk of severe adverse events. The primary aim of this study was to examine if administering chloroquine during COVID-19 imposed an increased risk of ischemic heart injury or heart failure.\n\nMedical records, laboratory findings, and electrocardiograms of patients with COVID-19 who were treated with 500 mg chloroquine phosphate daily and controls not treated with chloroquine were reviewed retrospectively. Controls were matched in age and severity of disease.\n\nWe included 20 patients receiving chloroquine (500 mg twice daily) for an average of five days, and 40 controls. The groups were comparable regarding demographics and biochemical analyses including C-reactive protein, thrombocytes, and creatinine. There were no statistically significant differences in cardiac biomarkers or in electrocardiograms. Median troponin T was 10,8 ng/L in the study group and 17.9 ng/L in the control group, whereas median NT-proBNP was 399 ng/L in patients receiving chloroquine and 349 ng/L in the controls.\n\nWe found no increased risk of ischemic heart injury or heart failure as a result of administering chloroquine. However, the use of chloroquine to treat COVID-19 outside of clinical trials is not recommended, considering the lack of evidence of its effectiveness, as well as the elevated risk of fatal arrythmias.", "doi": "10.1371/journal.pone.0256035", "pmid": "34398893", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8366976"}, {"db": "pii", "key": "PONE-D-21-05531"}], "notes": [], "created": "2021-08-17T06:33:30.817Z", "modified": "2023-06-19T14:22:31.683Z"}, {"entity": "publication", "iuid": "f4d2a4bb9cc542238ce4a63f1852e405", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f4d2a4bb9cc542238ce4a63f1852e405.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f4d2a4bb9cc542238ce4a63f1852e405"}}, "title": "The New Generation hDHODH Inhibitor MEDS433 Hinders the In Vitro Replication of SARS-CoV-2 and Other Human Coronaviruses.", "authors": [{"family": "Calistri", "given": "Arianna", "initials": "A", "orcid": "0000-0002-6881-7936", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbe9daeedf2e470da0d6dc15c0ad0b42.json"}}, {"family": "Luganini", "given": "Anna", "initials": "A", "orcid": "0000-0003-4256-5774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d50b50e8ca94f6cae15ba017327c531.json"}}, {"family": "Mognetti", "given": "Barbara", "initials": "B", "orcid": "0000-0003-2888-8999", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d3c5265b63e4d5b876a49be6ff1fdcb.json"}}, {"family": "Elder", "given": "Elizabeth", "initials": "E"}, {"family": "Sibille", "given": "Giulia", "initials": "G", "orcid": "0000-0002-2869-357X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c182e329cc844e8a77cc79d9aa3066b.json"}}, {"family": "Conciatori", "given": "Valeria", "initials": "V"}, {"family": "Del Vecchio", "given": "Claudia", "initials": "C"}, {"family": "Sainas", "given": "Stefano", "initials": "S", "orcid": "0000-0001-5010-8536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76b9175a3f6948ce805df8750a31af27.json"}}, {"family": "Boschi", "given": "Donatella", "initials": "D", "orcid": "0000-0003-4929-4460", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/553f31793fda4fffb7b98c6ffe323957.json"}}, {"family": "Montserrat", "given": "Nuria", "initials": "N"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Lolli", "given": "Marco Lucio", "initials": "ML"}, {"family": "Gribaudo", "given": "Giorgio", "initials": "G", "orcid": "0000-0002-1583-9146", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b1ea434d6b04d26a764cde7dd4ff21b.json"}}, {"family": "Parolin", "given": "Cristina", "initials": "C"}], "type": "journal article", "published": "2021-08-14", "journal": {"title": "Microorganisms", "issn": "2076-2607", "issn-l": "2076-2607", "volume": "9", "issue": "8", "pages": "1731"}, "abstract": "Although coronaviruses (CoVs) have long been predicted to cause zoonotic diseases and pandemics with high probability, the lack of effective anti-pan-CoVs drugs rapidly usable against the emerging SARS-CoV-2 actually prevented a promptly therapeutic intervention for COVID-19. Development of host-targeting antivirals could be an alternative strategy for the control of emerging CoVs infections, as they could be quickly repositioned from one pandemic event to another. To contribute to these pandemic preparedness efforts, here we report on the broad-spectrum CoVs antiviral activity of MEDS433, a new inhibitor of the human dihydroorotate dehydrogenase (hDHODH), a key cellular enzyme of the de novo pyrimidine biosynthesis pathway. MEDS433 inhibited the in vitro replication of hCoV-OC43 and hCoV-229E, as well as of SARS-CoV-2, at low nanomolar range. Notably, the anti-SARS-CoV-2 activity of MEDS433 against SARS-CoV-2 was also observed in kidney organoids generated from human embryonic stem cells. Then, the antiviral activity of MEDS433 was reversed by the addition of exogenous uridine or the product of hDHODH, the orotate, thus confirming hDHODH as the specific target of MEDS433 in hCoVs-infected cells. Taken together, these findings suggest MEDS433 as a potential candidate to develop novel drugs for COVID-19, as well as broad-spectrum antiviral agents exploitable for future CoVs threats.", "doi": "10.3390/microorganisms9081731", "pmid": "34442810", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8398173"}, {"db": "pii", "key": "microorganisms9081731"}], "notes": [], "created": "2021-09-01T07:26:00.780Z", "modified": "2023-06-19T14:33:43.533Z"}, {"entity": "publication", "iuid": "1b3ba7feed27435d99d45ec43fa13eb4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b3ba7feed27435d99d45ec43fa13eb4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b3ba7feed27435d99d45ec43fa13eb4"}}, "title": "Risk of acute myocardial infarction and ischaemic stroke following COVID-19 in Sweden: a self-controlled case series and matched cohort study.", "authors": [{"family": "Katsoularis", "given": "Ioannis", "initials": "I"}, {"family": "Fonseca-Rodr\u00edguez", "given": "Osvaldo", "initials": "O"}, {"family": "Farrington", "given": "Paddy", "initials": "P"}, {"family": "Lindmark", "given": "Krister", "initials": "K"}, {"family": "Fors Connolly", "given": "Anne-Marie", "initials": "AM"}], "type": "journal article", "published": "2021-08-14", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "398", "issue": "10300", "pages": "599-607", "issn-l": "0140-6736"}, "abstract": "COVID-19 is a complex disease targeting many organs. Previous studies highlight COVID-19 as a probable risk factor for acute cardiovascular complications. We aimed to quantify the risk of acute myocardial infarction and ischaemic stroke associated with COVID-19 by analysing all COVID-19 cases in Sweden.\n\nThis self-controlled case series (SCCS) and matched cohort study was done in Sweden. The personal identification numbers of all patients with COVID-19 in Sweden from Feb 1 to Sept 14, 2020, were identified and cross-linked with national inpatient, outpatient, cancer, and cause of death registers. The controls were matched on age, sex, and county of residence in Sweden. International Classification of Diseases codes for acute myocardial infarction or ischaemic stroke were identified in causes of hospital admission for all patients with COVID-19 in the SCCS and all patients with COVID-19 and the matched control individuals in the matched cohort study. The SCCS method was used to calculate the incidence rate ratio (IRR) for first acute myocardial infarction or ischaemic stroke following COVID-19 compared with a control period. The matched cohort study was used to determine the increased risk that COVID-19 confers compared with the background population of increased acute myocardial infarction or ischaemic stroke in the first 2 weeks following COVID-19.\n\n86 742 patients with COVID-19 were included in the SCCS study, and 348 481 matched control individuals were also included in the matched cohort study. When day of exposure was excluded from the risk period in the SCCS, the IRR for acute myocardial infarction was 2\u00b789 (95% CI 1\u00b751-5\u00b755) for the first week, 2\u00b753 (1\u00b729-4\u00b794) for the second week, and 1\u00b760 (0\u00b784-3\u00b704) in weeks 3 and 4 following COVID-19. When day of exposure was included in the risk period, IRR was 8\u00b744 (5\u00b745-13\u00b708) for the first week, 2\u00b756 (1\u00b731-5\u00b701) for the second week, and 1\u00b762 (0\u00b785-3\u00b709) for weeks 3 and 4 following COVID-19. The corresponding IRRs for ischaemic stroke when day of exposure was excluded from the risk period were 2\u00b797 (1\u00b771-5\u00b715) in the first week, 2\u00b780 (1\u00b760-4\u00b788) in the second week, and 2\u00b710 (1\u00b733-3\u00b732) in weeks 3 and 4 following COVID-19; when day of exposure was included in the risk period, the IRRs were 6\u00b718 (4\u00b706-9\u00b742) for the first week, 2\u00b785 (1\u00b764-4\u00b797) for the second week, and 2\u00b714 (1\u00b736-3\u00b738) for weeks 3 and 4 following COVID-19. In the matched cohort analysis excluding day 0, the odds ratio (OR) for acute myocardial infarction was 3\u00b741 (1\u00b758-7\u00b736) and for stroke was 3\u00b763 (1\u00b769-7\u00b780) in the 2 weeks following COVID-19. When day 0 was included in the matched cohort study, the OR for acute myocardial infarction was 6\u00b761 (3\u00b756-12\u00b720) and for ischaemic stroke was 6\u00b774 (3\u00b771-12\u00b720) in the 2 weeks following COVID-19.\n\nOur findings suggest that COVID-19 is a risk factor for acute myocardial infarction and ischaemic stroke. This indicates that acute myocardial infarction and ischaemic stroke represent a part of the clinical picture of COVID-19, and highlights the need for vaccination against COVID-19.\n\nCentral ALF-funding and Base Unit ALF-Funding, Region V\u00e4sterbotten, Sweden; Strategic funding during 2020 from the Department of Clinical Microbiology, Ume\u00e5 University, Sweden; Stroke Research in Northern Sweden; The Laboratory for Molecular Infection Medicine Sweden.", "doi": "10.1016/S0140-6736(21)00896-5", "pmid": "34332652", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8321431"}, {"db": "pii", "key": "S0140-6736(21)00896-5"}], "notes": [], "created": "2021-08-04T17:01:26.792Z", "modified": "2023-07-13T11:26:15.336Z"}, {"entity": "publication", "iuid": "76ce0eac73b046a3b39f4ca61d43e623", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76ce0eac73b046a3b39f4ca61d43e623.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76ce0eac73b046a3b39f4ca61d43e623"}}, "title": "The impact of first and second wave of COVID-19 on knee and hip surgeries in Sweden.", "authors": [{"family": "Dell'Isola", "given": "Andrea", "initials": "A", "orcid": "0000-0002-0319-458X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d8ea417b7c447f8bc4da9f47f9feb39.json"}}, {"family": "Kiadaliri", "given": "Ali", "initials": "A"}, {"family": "Turkiewicz", "given": "Aleksandra", "initials": "A"}, {"family": "Hughes", "given": "Velocity", "initials": "V"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}, {"family": "Runhaar", "given": "Jos", "initials": "J"}, {"family": "Bierma-Zeinstra", "given": "Sita", "initials": "S"}, {"family": "Englund", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2021-08-13", "journal": {"title": "J Exp Orthop", "issn": "2197-1153", "volume": "8", "issue": "1", "pages": "60", "issn-l": null}, "abstract": "To investigate the impact of COVID-19 in Sweden on rates of knee and hip surgeries.\n\nWe used healthcare data for the population of the southernmost region in Sweden (1.4 million inhabitants). We did an interrupted time-series analysis to estimate changes in rates and trends of joint replacements (JR), arthroscopies, and fracture surgeries for knee or hip in April-December 2020 compared to pre-COVID-19 levels adjusting for seasonal variations.\n\nWe found a drop of 54% (95% CI 42%; 68%) and 42% (95% CI 32%; 52%), respectively, in the rate of JRs and arthroscopies in April 2020 when compared to the counterfactual scenario. This was followed by an increase that brought the rates of JRs and arthroscopies back to their predicted levels also during the beginning of the second wave (November-December 2020). Acute fracture surgeries were largely unaffected, i.e. did not show any decrease as observed for the other surgeries.\n\nIn southern Sweden, we observed a marked decrease in elective knee and hip surgeries following the first wave of Covid-19. The rates remained close to normal during the beginning of the second wave suggesting that important elective surgeries for patients with end-stage osteoarthritis can still be offered despite an ongoing pandemic provided adequate routines and hospital resources.", "doi": "10.1186/s40634-021-00382-7", "pmid": "34389919", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s40634-021-00382-7"}], "notes": [], "created": "2021-08-16T09:31:35.898Z", "modified": "2021-08-16T09:31:35.951Z"}, {"entity": "publication", "iuid": "1093e74c258e4557b0c0b7cf5b9a8ebf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1093e74c258e4557b0c0b7cf5b9a8ebf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1093e74c258e4557b0c0b7cf5b9a8ebf"}}, "title": "Patterns of prescription dispensation and over-the-counter medication sales in Sweden during the COVID-19 pandemic.", "authors": [{"family": "Karlsson", "given": "P\u00e4r", "initials": "P"}, {"family": "Nakitanda", "given": "Aya Olivia", "initials": "AO"}, {"family": "L\u00f6fling", "given": "Lukas", "initials": "L", "orcid": "0000-0002-2731-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/791065e777f04244b251fb5a167cf33f.json"}}, {"family": "Cesta", "given": "Carolyn E", "initials": "CE", "orcid": "0000-0001-5759-9366", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd628fbbf6614769a1d8ad40b78b8093.json"}}], "type": "journal article", "published": "2021-08-13", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "8", "pages": "e0253944", "issn-l": "1932-6203"}, "abstract": "On February 26th 2020, a high alert was issued in Sweden in response to the diagnosis of the first few coronavirus disease 2019 (COVID-19) cases in the country. Subsequently, a decreased supply of essential goods, including medical products, was anticipated. We aimed to explore the weekly patterns of prescription dispensing and over-the-counter (OTC) medication sales in Sweden in 2020 compared with previous years, to assess the influence of the government restrictions on medication sales, and to assess whether there is evidence of medication stockpiling in the population.\n\nAggregated data on the weekly volume of defined daily doses (DDDs) of prescription medication dispensed and OTC sales from 2015 to 2020 were examined. From 2015-2019 data, the predicted weekly volume of DDDs for 2020 was estimated and compared to the observed volume for each ATC anatomical main group and therapeutic subgroup.\n\nFrom mid-February to mid-March 2020, there were increases in the weekly volumes of dispensed medication, peaking in the second week of March with a 46% increase in the observed versus predicted number of DDDs dispensed (16,440 vs 11,260 DDDs per 1000 inhabitants). A similar pattern was found in all age groups, in both sexes, and across metropolitan and non-metropolitan regions. In the same week in March, there was a 96% increase in the volume of OTC sold (2,504 vs 1,277 DDDs per 1000 inhabitants), specifically in ATC therapeutic subgroups including vitamins, antipyretics, painkillers, and nasal, throat, cough and cold preparations.\n\nBeginning in mid-February 2020, there were significant changes in the volume of prescription medication dispensed and OTC drugs sold. The weekly volume of DDDs quickly decreased following recommendations from public authorities. Overall, our findings suggest stockpiling behavior over a surge in new users of medication.", "doi": "10.1371/journal.pone.0253944", "pmid": "34388166", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-06619"}], "notes": [], "created": "2021-08-16T09:23:40.853Z", "modified": "2021-08-16T09:23:40.907Z"}, {"entity": "publication", "iuid": "762adfb81a5b46adadce0d32a76d9bfd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/762adfb81a5b46adadce0d32a76d9bfd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/762adfb81a5b46adadce0d32a76d9bfd"}}, "title": "Genetic-based adaptive momentum estimation for predicting mortality risk factors for COVID-19 patients using deep learning.", "authors": [{"family": "Elghamrawy", "given": "Sally M", "initials": "SM", "orcid": "0000-0002-5430-390X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed6eb2f2b245401b8ad977256a3e918d.json"}}, {"family": "Hassanien", "given": "Aboul Ella", "initials": "AE", "orcid": "0000-0002-9989-6681", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28d8d8edeb454ee78721318261a3f18c.json"}}, {"family": "Vasilakos", "given": "Athanasios V", "initials": "AV", "orcid": "0000-0003-1902-9877", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3315b301bfc45188d847998d929de44.json"}}], "type": "journal article", "published": "2021-08-13", "journal": {"title": "Int J Imaging Syst Technol", "issn": "0899-9457", "issn-l": null}, "abstract": "The mortality risk factors for coronavirus disease (COVID-19) must be early predicted, especially for severe cases, to provide intensive care before they develop to critically ill immediately. This paper aims to develop an optimized convolution neural network (CNN) for predicting mortality risk factors for COVID-19 patients. The proposed model supports two types of input data clinical variables and the computed tomography (CT) scans. The features are extracted from the optimized CNN phase and then applied to the classification phase. The CNN model's hyperparameters were optimized using a proposed genetic-based adaptive momentum estimation (GB-ADAM) algorithm. The GB-ADAM algorithm employs the genetic algorithm (GA) to optimize Adam optimizer's configuration parameters, consequently improving the classification accuracy. The model is validated using three recent cohorts from New York, Mexico, and Wuhan, consisting of 3055, 7497,504 patients, respectively. The results indicated that the most significant mortality risk factors are: CD T Lymphocyte (Count), D-dimer greater than 1 Ug/ml, high values of lactate dehydrogenase (LDH), C-reactive protein (CRP), hypertension, and diabetes. Early identification of these factors would help the clinicians in providing immediate care. The results also show that the most frequent COVID-19 signs in CT scans included ground-glass opacity (GGO), followed by crazy-paving pattern, consolidations, and the number of lobes. Moreover, the experimental results show encouraging performance for the proposed model compared with different predicting models. 8 +", "doi": "10.1002/ima.22644", "pmid": "34518740", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "IMA22644"}, {"db": "pmc", "key": "PMC8426801"}], "notes": [], "created": "2021-09-20T06:28:02.045Z", "modified": "2021-09-20T06:28:17.272Z"}, {"entity": "publication", "iuid": "c3f75996c34f458d839411152ca3bb3f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3f75996c34f458d839411152ca3bb3f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3f75996c34f458d839411152ca3bb3f"}}, "title": "COVID-19 vaccine uptake among older people in relation to sociodemographic factors \u2013cohort results from southern Sweden", "authors": [{"family": "Inghammar", "given": "Malin", "initials": "M", "orcid": "0000-0003-2995-1312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4ab710428614cccb2a537ecab31d0a0.json"}}, {"family": "Moghaddassi", "given": "Mahnaz", "initials": "M", "orcid": "0000-0002-0844-4736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a219bde5ba8a4f3f8655ada08d749885.json"}}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}, {"family": "Malmqvist", "given": "Ulf", "initials": "U"}, {"family": "Kahn", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-5566-6350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42eda71f3775400599febc10a4e7359c.json"}}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J", "orcid": "0000-0003-1883-2000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e88fdca336ae41c891f0a46e2481b67f.json"}}], "type": "posted-content", "published": "2021-08-13", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.08.12.21261981", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-08-16T11:25:49.928Z", "modified": "2021-11-29T06:15:40.860Z"}, {"entity": "publication", "iuid": "097f0660da62413b87a2a1e5b5db78de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/097f0660da62413b87a2a1e5b5db78de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/097f0660da62413b87a2a1e5b5db78de"}}, "title": "Applications of Artificial Intelligence, Machine Learning, Big Data and the Internet of Things to the COVID-19 Pandemic: A Scientometric Review Using Text Mining.", "authors": [{"family": "Rodr\u00edguez-Rodr\u00edguez", "given": "Ignacio", "initials": "I", "orcid": "0000-0002-0118-3406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7dade1cd1ba4f55b4851886236a8f2f.json"}}, {"family": "Rodr\u00edguez", "given": "Jos\u00e9-V\u00edctor", "initials": "JV", "orcid": "0000-0002-3298-6439", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1fa087057b0d4db88f835464f5236c24.json"}}, {"family": "Shirvanizadeh", "given": "Niloofar", "initials": "N"}, {"family": "Ortiz", "given": "Andr\u00e9s", "initials": "A", "orcid": "0000-0003-2690-1926", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49783f8986ae4250b181ee1a68c3df35.json"}}, {"family": "Pardo-Quiles", "given": "Domingo-Javier", "initials": "DJ", "orcid": "0000-0003-3240-2568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/334b10db57e745928464250074151e78.json"}}], "type": "journal article", "published": "2021-08-13", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "16", "issn-l": null}, "abstract": "The COVID-19 pandemic has wreaked havoc in every country in the world, with serious health-related, economic, and social consequences. Since its outbreak in March 2020, many researchers from different fields have joined forces to provide a wide range of solutions, and the support for this work from artificial intelligence (AI) and other emerging concepts linked to intelligent data analysis has been decisive. The enormous amount of research and the high number of publications during this period makes it difficult to obtain an overall view of the different applications of AI to the management of COVID-19 and an understanding of how research in this field has been evolving. Therefore, in this paper, we carry out a scientometric analysis of this area supported by text mining, including a review of 18,955 publications related to AI and COVID-19 from the Scopus database from March 2020 to June 2021 inclusive. For this purpose, we used VOSviewer software, which was developed by researchers at Leiden University in the Netherlands. This allowed us to examine the exponential growth in research on this issue and its distribution by country, and to highlight the clear hegemony of the United States (USA) and China in this respect. We used an automatic process to extract topics of research interest and observed that the most important current lines of research focused on patient-based solutions. We also identified the most relevant journals in terms of the COVID-19 pandemic, demonstrated the growing value of open-access publication, and highlighted the most influential authors by means of an analysis of citations and co-citations. This study provides an overview of the current status of research on the application of AI to the pandemic.", "doi": "10.3390/ijerph18168578", "pmid": "34444327", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijerph18168578"}, {"db": "pmc", "key": "PMC8393243"}], "notes": [], "created": "2021-09-01T07:26:54.980Z", "modified": "2021-09-01T07:26:55.090Z"}, {"entity": "publication", "iuid": "c92743112e0b41f9b2e3e36932da3580", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c92743112e0b41f9b2e3e36932da3580.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c92743112e0b41f9b2e3e36932da3580"}}, "title": "Neutralization of VOCs including Delta one year post COVID-19 or vaccine", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Ng", "given": "Henry", "initials": "H"}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Lindbo", "given": "Sarah", "initials": "S"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "posted-content", "published": "2021-08-12", "journal": {"title": "MedRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.08.12.21261951", "pmid": null, "labels": {"Type: Preprint": null, "Research Area: Host cell systems biology and targets": null, "Research Area: Drug discovery and repurposing of drugs": null, "Category: Biochemistry": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Research Area: High-throughput and high-content serology": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-08-16T11:27:28.128Z", "modified": "2023-06-19T14:28:25.881Z"}, {"entity": "publication", "iuid": "39de810995674ece9f905bd11df5bd41", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/39de810995674ece9f905bd11df5bd41.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/39de810995674ece9f905bd11df5bd41"}}, "title": "Low mortality rates among critically-ill adults with COVID-19 at three non-academic intensive care units in south Sweden.", "authors": [{"family": "Taxbro", "given": "Knut", "initials": "K", "orcid": "0000-0001-8711-9044", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53d41b4a81184f4da24af4065e0371e1.json"}}, {"family": "Granath", "given": "Andreas", "initials": "A"}, {"family": "Sunnergren", "given": "Ola", "initials": "O"}, {"family": "Seifert", "given": "Stefanie", "initials": "S"}, {"family": "Jakubczyk", "given": "Milena N", "initials": "MN"}, {"family": "Persson", "given": "Magnus", "initials": "M"}, {"family": "Hammarskj\u00f6ld", "given": "Anneli", "initials": "A"}, {"family": "Alkemark", "given": "Catarina", "initials": "C"}, {"family": "Hammarskj\u00f6ld", "given": "Fredrik", "initials": "F"}, {"family": "RJL COVID-19 research group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-08-12", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172"}, "abstract": "The COVID-19 pandemic has put an exceptional strain on intensive care units worldwide. During the first year, the survival of patients with acute hypoxaemic respiratory failure appears to have improved. We aimed to describe the mortality rates, management characteristics, and two pandemic waves during the first year at three non-academic rural intensive care units in Sweden.\n\nWe retrospectively analysed all cases of COVID-19 admitted to intensive care units in Region J\u00f6nk\u00f6ping County during one year. The primary endpoint was 30-day mortality.\n\nBetween 14th March 2020 and 13th March 2021, two-hundred and sixty-four patients were admitted to undergo intensive care with confirmed SARS-CoV-2 infection. The 30-day mortality rate after the initial intensive care admission was 12.9%, and this rate remained unchanged during both pandemic waves. However, we found several distinct differences between the two pandemic waves, including an increase in the use of high-flow nasal oxygen but a decrease in invasive mechanical ventilation use, biochemical markers of inflammation, continuous renal replacement therapy, and length of stay in the intensive care unit.\n\nOur study showed that critically ill patients with COVID-19 in Sweden have a low 30-day mortality rate which compares well with results published from academic centres and national cohorts throughout Scandinavia. During the second pandemic wave, the proportion of patients receiving invasive mechanical ventilation and continuous renal replacement therapy was lower than that in the first wave. This could be the result of increased knowledge and improved therapeutic options.", "doi": "10.1111/aas.13972", "pmid": "34386972", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-16T09:24:31.418Z", "modified": "2021-08-16T09:24:31.457Z"}, {"entity": "publication", "iuid": "a6742f8afc5b48b3897d5ef91387d725", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6742f8afc5b48b3897d5ef91387d725.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6742f8afc5b48b3897d5ef91387d725"}}, "title": "Air pollution and COVID-19: clearing the air and charting a post-pandemic course: a joint workshop report of ERS, ISEE, HEI and WHO", "authors": [{"family": "Andersen", "given": "Zorana J", "initials": "ZJ"}, {"family": "Hoffmann", "given": "Barbara", "initials": "B"}, {"family": "Morawska", "given": "Lidia", "initials": "L"}, {"family": "Adams", "given": "Martin", "initials": "M"}, {"family": "Furman", "given": "Eeva", "initials": "E"}, {"family": "Yorgancioglu", "given": "Arzu", "initials": "A"}, {"family": "Greenbaum", "given": "Dan", "initials": "D"}, {"family": "Neira", "given": "Maria", "initials": "M"}, {"family": "Brunekreef", "given": "Bert", "initials": "B"}, {"family": "Forastiere", "given": "Francesco", "initials": "F"}, {"family": "Rice", "given": "Mary B", "initials": "MB", "orcid": "0000-0003-2538-391X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b3b44173ee84de8bde4fe34352e40c3.json"}}, {"family": "Wakenhut", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Coleen", "given": "Erika", "initials": "E"}, {"family": "Boogaard", "given": "Hanna", "initials": "H"}, {"family": "Gehring", "given": "Ulrike", "initials": "U"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E", "orcid": "0000-0002-8248-0663", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58e96082947e4752a23f322e42754097.json"}}, {"family": "Ward", "given": "Brian", "initials": "B"}, {"family": "De Matteis", "given": "Sara", "initials": "S"}], "type": "journal-article", "published": "2021-08-12", "journal": {"title": "Eur Respir J", "issn": "0903-1936", "pages": "2101063", "issn-l": null}, "abstract": null, "doi": "10.1183/13993003.01063-2021", "pmid": null, "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-13T12:02:19.682Z", "modified": "2021-08-13T12:02:19.748Z"}, {"entity": "publication", "iuid": "8459545312984087acc8365e1a3b8290", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8459545312984087acc8365e1a3b8290.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8459545312984087acc8365e1a3b8290"}}, "title": "Post-Covid-19 Tachycardia Syndrome: A distinct phenotype of Post-acute Covid-19 Syndrome.", "authors": [{"family": "St\u00e5hlberg", "given": "Marcus", "initials": "M"}, {"family": "Reistam", "given": "Ulrika", "initials": "U"}, {"family": "Fedorowski", "given": "Artur", "initials": "A"}, {"family": "Villacorta", "given": "Humberto", "initials": "H"}, {"family": "Horiuchi", "given": "Yu", "initials": "Y"}, {"family": "Bax", "given": "Jeroen", "initials": "J"}, {"family": "Pitt", "given": "Bertram", "initials": "B"}, {"family": "Matskeplishvili", "given": "Simon", "initials": "S"}, {"family": "L\u00fcscher", "given": "Thomas F", "initials": "TF"}, {"family": "Weichert", "given": "Immo", "initials": "I"}, {"family": "Thani", "given": "Khalid Bin", "initials": "KB"}, {"family": "Maisel", "given": "Alan", "initials": "A"}], "type": "journal article", "published": "2021-08-11", "journal": {"title": "Am J Med", "issn": "1555-7162", "issn-l": null}, "abstract": "In this paper we highlight the presence of tachycardia in Post-acute Covid-19 Syndrome by introducing a new label for this phenomenon: Post-covid-19 tachycardia syndrome and argue that this constitutes a phenotype or sub-syndrome in PACS. We also discuss epidemiology, putative mechanisms, treatment options and future research directions in this novel clinical syndrome.", "doi": "10.1016/j.amjmed.2021.07.004", "pmid": "34390682", "labels": {"Type: Review": null, "Category: Post-COVID": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0002-9343(21)00472-1"}], "notes": [], "created": "2021-08-16T09:19:42.823Z", "modified": "2021-08-16T09:19:42.827Z"}, {"entity": "publication", "iuid": "662c8a91e61245ef9e66193caf062884", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/662c8a91e61245ef9e66193caf062884.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/662c8a91e61245ef9e66193caf062884"}}, "title": "Ovulatory upregulation of angiotensin-converting enzyme 2, a receptor for SARS-CoV-2, in dominant follicles of the human ovary.", "authors": [{"family": "Choi", "given": "Yohan", "initials": "Y"}, {"family": "Jeon", "given": "Hayce", "initials": "H"}, {"family": "Br\u00e4nnstr\u00f6m", "given": "Mats", "initials": "M"}, {"family": "Akin", "given": "James W", "initials": "JW"}, {"family": "Curry", "given": "Thomas E", "initials": "TE"}, {"family": "Jo", "given": "Misung", "initials": "M"}], "type": "journal article", "published": "2021-08-11", "journal": {"title": "Fertil Steril", "issn": "1556-5653", "issn-l": null}, "abstract": "To determine the temporal expression of angiotensin-converting enzyme 2 (ACE2), a receptor for SARS-CoV-2, in dominant follicles throughout the periovulatory period in women and the regulatory mechanisms underlying ACE2 expression in human granulosa/lutein cells (hGLC).\n\nExperimental prospective clinical study and laboratory-based investigation.\n\nUniversity Medical Center and private in vitro fertilization center.\n\nThirty premenopausal women undergoing surgery for tubal ligation and 16 premenopausal women undergoing in vitro fertilization.\n\nAdministration of human chorionic gonadotropin (hCG) and harvesting of preovulatory/ovulatory follicles by timed laparoscopy, and collection of granulosa/lutein cells and cumulus cells at the time of oocyte retrieval.\n\nExpression and localization of ACE2 in granulosa cells and dominant follicles collected throughout the periovulatory period of the menstrual cycle and in hGLC using quantitative polymerase chain reaction, immunoblotting, and immunohistochemistry.\n\nACE2 expression (mRNA and protein) is up-regulated in human ovulatory follicles after administration of hCG. ACE2 expression was higher in cumulus cells than in granulosa cells. hCG increased the expression of ACE2 in primary hGLC cultures; the increase was inhibited by RU486 (an antagonist for progesterone receptor and glucocorticoid receptor) and CORT125281 (a selective glucocorticoid receptor antagonist), but not by AG1478 (an EGF receptor tyrosine kinase inhibitor) or by dexamethasone.\n\nThe hormone-regulated expression of ACE2 in granulosa cells suggests a potential role of ACE2 in the ovulatory process. These data also imply the possible impact of COVID-19 on a vital cyclic event of ovarian function and thus on women's overall reproductive health. However, SAR-CoV-2 infection in ovarian cells in vivo or in vitro has yet to be determined.", "doi": "10.1016/j.fertnstert.2021.08.009", "pmid": "34538460", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0015-0282(21)01932-4"}, {"db": "pmc", "key": "PMC8354803"}], "notes": [], "created": "2021-10-10T15:33:54.875Z", "modified": "2021-10-10T15:33:54.901Z"}, {"entity": "publication", "iuid": "e429c397680849fa8fb8e42ec170e9a7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e429c397680849fa8fb8e42ec170e9a7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e429c397680849fa8fb8e42ec170e9a7"}}, "title": "Healthcare professionals' experiences during the initial stage of the COVID-19 pandemic in the intensive care unit: A qualitative study.", "authors": [{"family": "Mortensen", "given": "Camilla Bekker", "initials": "CB"}, {"family": "Zachodnik", "given": "Josephine", "initials": "J"}, {"family": "Caspersen", "given": "Sidsel Fjordbak", "initials": "SF"}, {"family": "Geisler", "given": "Anja", "initials": "A"}], "type": "journal article", "published": "2021-08-11", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "pages": "103130", "issn-l": null}, "abstract": "The COVID-19 pandemic called for rapidly considerable changes in the healthcare system. Healthcare professionals from different departments within the hospital settings were enrolled in the emergency preparedness. This study, therefore, aimed to explore the healthcare professionals' experiences attending the ICU-preparedness and caring for patients with COVID-19 during the initial stage of the pandemic.\n\nA descriptive explorative qualitative study was conducted by interviewing healthcare professionals during spring 2020, exploring their experiences as part of the ICU-preparedness team and caring for patients with COVID-19 in the ICU. Healthcare professionals from different departments were recruited by purposive sampling. The interviews were transcribed verbatim and analysed using content analysis.\n\nSixteen nurses and four physicians from a university hospital in Denmark participated. The analysis revealed three main themes and eight sub-themes. The main themes were (1) Professionalism in work-life (adaption, the patient's welfare, insecurity, and security), (2) Community Spirit (responsibility and contribution), and (3) Institutional organisation (the role of management, loss of freedom, and information).\n\nDespite work specialities and professions, the participants reported a uniformity of similar experiences of uncertainties, but also a sense of community arose during the first phase of COVID-19.\n\nTo ensure resilience and mental health, and well-being for the healthcare professionals, comprehensive support should be provided. Guidelines for interventions and training are necessary to promote preparedness and reduce psychological stress.", "doi": "10.1016/j.iccn.2021.103130", "pmid": "34538544", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(21)00119-1"}, {"db": "pmc", "key": "PMC8354791"}], "notes": [], "created": "2021-10-10T15:34:21.827Z", "modified": "2021-10-10T15:34:21.840Z"}, {"entity": "publication", "iuid": "3bda20886f3740a59941eacb08330d9a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3bda20886f3740a59941eacb08330d9a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3bda20886f3740a59941eacb08330d9a"}}, "title": "Fathering Practices in Sweden During the COVID-19: Experiences of Syrian Refugee Fathers.", "authors": [{"family": "Wiss\u00f6", "given": "Ther\u00e9se", "initials": "T"}, {"family": "B\u00e4ck-Wiklund", "given": "Margareta", "initials": "M"}], "type": "journal article", "published": "2021-08-11", "journal": {"title": "Front Sociol", "issn": "2297-7775", "issn-l": null, "volume": "6", "issue": null, "pages": "721881"}, "abstract": "This article explores fathering practices among Syrian refugee families in Sweden. Syrian refugees provide an example of people who migrated because of a single major event: the war in Syria. The article examines the impact of the COVID-19 pandemic on fathering practices. The Swedish COVID-19 strategy differed from those adopted in many other countries. Lockdowns were minimal and were not stringently enforced, based on the assumption that individuals would trust the authorities and would take personal responsibility for complying with their guidelines and recommendations. Previous research suggests that migrants and other vulnerable groups were not always well informed about the public policies introduced prior to and during the pandemic. The article draws on empirical data from a wider research project on the family lives of Syrian migrants in Sweden. The authors present their findings from an analysis of eleven ethnographically informed semi-structured interviews, carried out before and during the pandemic, with married fathers who had been living in Sweden for several years. In this article, they focus on three cases representing fathers with varied educational backgrounds and employment histories. These families had in common what are considered by Swedish standards to be overcrowded living conditions; they were forced to accept close family proximity, both physically and emotionally, as they no longer had the supportive networks they were used to in Syria. The three fathers were found to rely more heavily on information provided by the people with whom they were in contact in Sweden than on policies and recommendations from the authorities. These findings confirmed that the previous experiences among refugees of shifting policies regarding migration and integration had lowered their trust in government. They had learnt that they needed to rely on mutual dependency not only between spouses, but also between parents and children.", "doi": "10.3389/fsoc.2021.721881", "pmid": "34458362", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "721881"}, {"db": "pmc", "key": "PMC8385311"}], "notes": [], "created": "2021-09-01T07:47:01.167Z", "modified": "2022-11-23T08:53:49.788Z"}, {"entity": "publication", "iuid": "63111781bc1e427aa45a890921711381", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63111781bc1e427aa45a890921711381.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63111781bc1e427aa45a890921711381"}}, "title": "Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling.", "authors": [{"family": "Mishra", "given": "Swapnil", "initials": "S", "orcid": "0000-0002-8759-5902", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9090a94ef6b43e59561319e56b1fcc8.json"}}, {"family": "Scott", "given": "James A", "initials": "JA"}, {"family": "Laydon", "given": "Daniel J", "initials": "DJ", "orcid": "0000-0003-4270-3321", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/941e87bd83ed4474869d63d345cf8ff4.json"}}, {"family": "Flaxman", "given": "Seth", "initials": "S"}, {"family": "Gandy", "given": "Axel", "initials": "A"}, {"family": "Mellan", "given": "Thomas A", "initials": "TA"}, {"family": "Unwin", "given": "H Juliette T", "initials": "HJT", "orcid": "0000-0002-9120-4003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29efd6265a564f1890678af46df4ab5e.json"}}, {"family": "Vollmer", "given": "Michaela", "initials": "M"}, {"family": "Coupland", "given": "Helen", "initials": "H"}, {"family": "Ratmann", "given": "Oliver", "initials": "O"}, {"family": "Monod", "given": "Melodie", "initials": "M"}, {"family": "Zhu", "given": "Harrison H", "initials": "HH"}, {"family": "Cori", "given": "Anne", "initials": "A"}, {"family": "Gaythorpe", "given": "Katy A M", "initials": "KAM", "orcid": "0000-0003-3734-9081", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/faae9aff1d7c4b948de39fce64a55bc3.json"}}, {"family": "Whittles", "given": "Lilith K", "initials": "LK", "orcid": "0000-0002-8913-0391", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4635744009424fb5b72184abad9929ff.json"}}, {"family": "Whittaker", "given": "Charles", "initials": "C"}, {"family": "Donnelly", "given": "Christl A", "initials": "CA", "orcid": "0000-0002-0195-2463", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5e672e1b59c4d9c8d6c5ba3e5280dd9.json"}}, {"family": "Ferguson", "given": "Neil M", "initials": "NM", "orcid": "0000-0002-1154-8093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34d57563a33a4be7be974488684afbb7.json"}}, {"family": "Bhatt", "given": "Samir", "initials": "S"}], "type": "comparative study", "published": "2021-08-11", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "16342", "issn-l": "2045-2322"}, "abstract": "The UK and Sweden have among the worst per-capita COVID-19 mortality in Europe. Sweden stands out for its greater reliance on voluntary, rather than mandatory, control measures. We explore how the timing and effectiveness of control measures in the UK, Sweden and Denmark shaped COVID-19 mortality in each country, using a counterfactual assessment: what would the impact have been, had each country adopted the others' policies? Using a Bayesian semi-mechanistic model without prior assumptions on the mechanism or effectiveness of interventions, we estimate the time-varying reproduction number for the UK, Sweden and Denmark from daily mortality data. We use two approaches to evaluate counterfactuals which transpose the transmission profile from one country onto another, in each country's first wave from 13th March (when stringent interventions began) until 1st July 2020. UK mortality would have approximately doubled had Swedish policy been adopted, while Swedish mortality would have more than halved had Sweden adopted UK or Danish strategies. Danish policies were most effective, although differences between the UK and Denmark were significant for one counterfactual approach only. Our analysis shows that small changes in the timing or effectiveness of interventions have disproportionately large effects on total mortality within a rapidly growing epidemic.", "doi": "10.1038/s41598-021-95699-9", "pmid": "34381102", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8358009"}, {"db": "pii", "key": "10.1038/s41598-021-95699-9"}], "notes": [], "created": "2023-01-13T13:42:29.507Z", "modified": "2023-01-13T13:42:29.715Z"}, {"entity": "publication", "iuid": "b476270647504837acd317ffe5bf0994", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b476270647504837acd317ffe5bf0994.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b476270647504837acd317ffe5bf0994"}}, "title": "Soft law and individual responsibility: a review of the Swedish policy response to COVID-19.", "authors": [{"family": "Winblad", "given": "Ulrika", "initials": "U", "orcid": "0000-0002-3921-5522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af163cdcd01e4e348be01c344085ef2e.json"}}, {"family": "Swenning", "given": "Anna-Karin", "initials": "A"}, {"family": "Spangler", "given": "Douglas", "initials": "D"}], "type": "journal article", "published": "2021-08-10", "journal": {"title": "Health Econ Policy Law", "issn": "1744-134X", "issn-l": null, "volume": null, "issue": null, "pages": "1-14"}, "abstract": "Sweden's coronavirus disease 2019 (COVID-19) response, initially based largely on voluntary measures, has evoked strong reactions nationally and internationally. In this study, we describe Sweden's national policy response with regard to the general public, the community and the health care system, with a focus on how the response changed from March 2020 to June 2021. A number of factors contributed to Sweden's choice of policy response, including its existing legal framework, independent expert agencies and its decentralized, multi-level health care governance system. Challenges to the health- and elder care system during the pandemic, such as the need to increase intensive care- and testing capacity, and to ensure the safety of the elderly were addressed largely at the regional and local levels, with national authorities assuming a primarily coordinative role. Although the overall response based on voluntary compliance has persisted, the national government started to take a more prominent role in public messaging, and in enacting legally binding restrictions during subsequent waves of the pandemic. This study illustrates that not only policy responses, but also the fundamental structure of the health- and elder care system and its governance should be considered when evaluating the impact of the COVID-19 pandemic.", "doi": "10.1017/S1744133121000256", "pmid": "34372959", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1744133121000256"}, {"db": "pmc", "key": "PMC8387683"}], "notes": [], "created": "2021-08-11T14:30:17.809Z", "modified": "2021-11-18T13:32:02.858Z"}, {"entity": "publication", "iuid": "ad4e8a3cf6f241cb964898f14cfba40b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ad4e8a3cf6f241cb964898f14cfba40b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ad4e8a3cf6f241cb964898f14cfba40b"}}, "title": "Remdesivir in the COVID-19 Pandemic: An Analysis of Spontaneous Reports in VigiBase During 2020.", "authors": [{"family": "Rocca", "given": "Elena", "initials": "E"}, {"family": "Gauffin", "given": "Oskar", "initials": "O"}, {"family": "Savage", "given": "Ruth", "initials": "R"}, {"family": "Vidlin", "given": "Sara Hedfors", "initials": "SH"}, {"family": "Grundmark", "given": "Birgitta", "initials": "B", "orcid": "0000-0002-2799-9374", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af41b5a50729439f9ee9454393af8cdc.json"}}], "type": "journal article", "published": "2021-08-10", "journal": {"title": "Drug Saf", "issn": "1179-1942", "issn-l": "0114-5916"}, "abstract": "The safety profile of remdesivir, conditionally approved for COVID-19, was limited at its 2020 introduction. Adverse drug reactions (ADRs) for medicines are collected in VigiBase, the WHO Global Database of Individual Case Safety Reports (ICSRs).\n\nThis study aimed to provide a descriptive analysis of COVID-19 ICSR data focusing on remdesivir, including a disproportionality analysis (DA) of ADRs.\n\nA dedicated algorithm enabled retrieval of all COVID-19 treatment-specific ICSRs. A severity algorithm based on co-reported medicines and symptoms enabled selection of tocilizumab with its well established safety profile as comparator for remdesivir. Descriptive statistics were used for general ICSR demographics for all COVID-19-specific medicines, remdesivir and tocilizumab individually and furthermore to present treatment patterns of medicines co-reported with remdesivir. A COVID-19 indication-focused DA was deployed to minimize confounding from underlying polysymptomatic disease.\n\n14,574 COVID-19-related ICSRs were entered into VigiBase during 2020. Remdesivir was the most common medicine reported. Of 4944 remdesivir ICSRs, where tocilizumab was not co-reported, 93% described remdesivir as the sole suspect medicine. Sixty percent of ICSRs concerned males, median age was 63 years and the majority originated from the Americas (72%). In 1089 (21%) of remdesivir ICSRs, data indicated severe/critical disease. Co-reported medicines peaked during the first 3 days of remdesivir treatment. The DA for the established tocilizumab and the new remdesivir were mainly in line with the safety profiles for both medicines but suggested new safety concerns. The most reported ADRs for remdesivir represented liver dysfunction, kidney injury, death and bradycardia.\n\nGlobal COVID-19-related ADR reporting proved useful in providing information on ADRs as well as on treatment patterns in this patient group. Indication-focused disproportionality analysis, together with the use of a comparator with a known safety profile, proved effective in identifying known safety information and suggested new safety concerns for remdesivir.", "doi": "10.1007/s40264-021-01091-x", "pmid": "34374967", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40264-021-01091-x"}], "notes": [], "created": "2021-08-11T14:28:49.961Z", "modified": "2021-08-11T14:29:37.634Z"}, {"entity": "publication", "iuid": "594d9547784441abb908eeaf85ed0e79", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/594d9547784441abb908eeaf85ed0e79.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/594d9547784441abb908eeaf85ed0e79"}}, "title": "Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites.", "authors": [{"family": "Hoffmann", "given": "David", "initials": "D"}, {"family": "Mereiter", "given": "Stefan", "initials": "S"}, {"family": "Jin Oh", "given": "Yoo", "initials": "Y"}, {"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Elder", "given": "Elizabeth", "initials": "E"}, {"family": "Zhu", "given": "Rong", "initials": "R"}, {"family": "Canena", "given": "Daniel", "initials": "D"}, {"family": "Hain", "given": "Lisa", "initials": "L"}, {"family": "Laurent", "given": "Elisabeth", "initials": "E"}, {"family": "Gr\u00fcnwald-Gruber", "given": "Clemens", "initials": "C"}, {"family": "Klausberger", "given": "Miriam", "initials": "M"}, {"family": "Jonsson", "given": "Gustav", "initials": "G"}, {"family": "Kellner", "given": "Max J", "initials": "MJ"}, {"family": "Novatchkova", "given": "Maria", "initials": "M"}, {"family": "Ticevic", "given": "Melita", "initials": "M"}, {"family": "Chabloz", "given": "Antoine", "initials": "A"}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G"}, {"family": "Hagelkruys", "given": "Astrid", "initials": "A"}, {"family": "Altmann", "given": "Friedrich", "initials": "F"}, {"family": "Mach", "given": "Lukas", "initials": "L"}, {"family": "Stadlmann", "given": "Johannes", "initials": "J"}, {"family": "Oostenbrink", "given": "Chris", "initials": "C"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Hinterdorfer", "given": "Peter", "initials": "P"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}], "type": "journal article", "published": "2021-08-10", "journal": {"title": "EMBO J", "issn": "1460-2075", "pages": "e108375", "issn-l": null}, "abstract": "New SARS-CoV-2 variants are continuously emerging with critical implications for therapies or vaccinations. The 22 N-glycan sites of Spike remain highly conserved among SARS-CoV-2 variants, opening an avenue for robust therapeutic intervention. Here we used a comprehensive library of mammalian carbohydrate-binding proteins (lectins) to probe critical sugar residues on the full-length trimeric Spike and the receptor binding domain (RBD) of SARS-CoV-2. Two lectins, Clec4g and CD209c, were identified to strongly bind to Spike. Clec4g and CD209c binding to Spike was dissected and visualized in real time and at single molecule resolution using atomic force microscopy. 3D modelling showed that both lectins can bind to a glycan within the RBD-ACE2 interface and thus interferes with Spike binding to cell surfaces. Importantly, Clec4g and CD209c significantly reduced SARS-CoV-2 infections. These data report the first extensive map and 3D structural modelling of lectin-Spike interactions and uncovers candidate receptors involved in Spike binding and SARS-CoV-2 infections. The capacity of CLEC4G and mCD209c lectins to block SARS-CoV-2 viral entry holds promise for pan-variant therapeutic interventions.", "doi": "10.15252/embj.2021108375", "pmid": "34375000", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://covid.molssi.org//models/#spike-protein-in-complex-with-human-ace2-spike-spike-binding%29.", "description": "Structural models for used in virtual screening"}], "notes": [], "created": "2021-08-11T14:27:59.675Z", "modified": "2021-09-09T07:13:12.326Z"}, {"entity": "publication", "iuid": "862ac2f181b7434fb4559dff0c1b0e99", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/862ac2f181b7434fb4559dff0c1b0e99.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/862ac2f181b7434fb4559dff0c1b0e99"}}, "title": "The reproductive number of the Delta variant of SARS-CoV-2 is far higher compared to the ancestral SARS-CoV-2 virus.", "authors": [{"family": "Liu", "given": "Ying", "initials": "Y"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}], "type": "journal article", "published": "2021-08-09", "journal": {"title": "J Travel Med", "issn": "1708-8305", "issn-l": null}, "abstract": "The Delta variant is now replacing all other SARS-CoV-2 variants. We found a mean R0 of 5.08 which is much higher than the R0 of the ancestral strain of 2.79. Rapidly ramping up vaccine coverage rates while enhancing public health and social measures is now even more urgent and important.", "doi": "10.1093/jtm/taab124", "pmid": "34369565", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6346388"}], "notes": [], "created": "2021-08-11T14:33:55.820Z", "modified": "2021-08-11T14:33:55.832Z"}, {"entity": "publication", "iuid": "7bd8c3c52c7a410d990755358d816fdb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7bd8c3c52c7a410d990755358d816fdb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7bd8c3c52c7a410d990755358d816fdb"}}, "title": "Initial impact of SARS-Cov-2 vaccination on healthcare workers in Italy- Update on the 28th of March 2021.", "authors": [{"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Spuri", "given": "Matteo", "initials": "M"}, {"family": "D'Ancona", "given": "Fortunato", "initials": "F"}, {"family": "Filia", "given": "Antonietta", "initials": "A"}, {"family": "Rota", "given": "Maria Cristina", "initials": "MC"}, {"family": "Petrone", "given": "Daniele", "initials": "D"}, {"family": "Vescio", "given": "Maria Fenicia", "initials": "MF"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}], "type": "journal article", "published": "2021-08-09", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null, "volume": "39", "issue": "34", "pages": "4788-4792"}, "abstract": "In Italy, the COVID-19 vaccination campaign started in December 2020 with the vaccination of healthcare workers (HCW). To analyse the real-life impact that vaccination is having on this population group, we measured the association between week of diagnosis and HCW status using log-binomial regression. By the week 22-28 March, we observed a 74% reduction (PPR 0.26; 95% CI 0.22-0.29) in the proportion of cases reported as HCW and 81% reduction in the proportion of symptomatic cases reported as HCW, compared with the week with the lowest proportion of cases among HCWs prior to the vaccination campaign (31 August-7 September). The reduction, both in relative and absolute terms, of COVID-19 cases in HCWs that started around 30 days after the start of the vaccination campaign suggest that COVID-19 vaccines are being effective in preventing infection in this group.", "doi": "10.1016/j.vaccine.2021.07.003", "pmid": "34253419", "labels": {"Category: Public Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(21)00862-8"}, {"db": "pmc", "key": "PMC8260579"}], "notes": [], "created": "2021-08-06T07:34:29.106Z", "modified": "2021-12-07T15:29:24.754Z"}, {"entity": "publication", "iuid": "d8212176c72a4096a4852c29880b2ade", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d8212176c72a4096a4852c29880b2ade.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d8212176c72a4096a4852c29880b2ade"}}, "title": "Sample-to-answer COVID-19 nucleic acid testing using a low-cost centrifugal microfluidic platform with bead-based signal enhancement and smartphone read-out.", "authors": [{"family": "Soares", "given": "Ruben R G", "initials": "RRG", "orcid": "0000-0001-5958-5232", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2fc2815bc25c4fb78df63294947ee184.json"}}, {"family": "Akhtar", "given": "Ahmad S", "initials": "AS", "orcid": "0000-0002-4560-4735", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc3276d3eaca462fb80c2033d7bc0104.json"}}, {"family": "Pinto", "given": "In\u00eas F", "initials": "IF", "orcid": "0000-0002-9714-4742", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f94e94cf2e14c3cb4ce6f8d7235ea8b.json"}}, {"family": "Lapins", "given": "Noa", "initials": "N"}, {"family": "Barrett", "given": "Donal", "initials": "D"}, {"family": "Sandh", "given": "Gustaf", "initials": "G"}, {"family": "Yin", "given": "Xiushan", "initials": "X"}, {"family": "Pelechano", "given": "Vicent", "initials": "V", "orcid": "0000-0002-9415-788X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce53b4c829e547399014c2d8042dde35.json"}}, {"family": "Russom", "given": "Aman", "initials": "A", "orcid": "0000-0002-0242-358X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a36512bc999441bfa671e316fa9e89b4.json"}}], "type": "journal article", "published": "2021-08-07", "journal": {"title": "Lab Chip", "issn": "1473-0189", "issn-l": null, "volume": "21", "issue": "15", "pages": "2932-2944"}, "abstract": "With its origin estimated around December 2019 in Wuhan, China, the ongoing SARS-CoV-2 pandemic is a major global health challenge. The demand for scalable, rapid and sensitive viral diagnostics is thus particularly pressing at present to help contain the rapid spread of infection and prevent overwhelming the capacity of health systems. While high-income countries have managed to rapidly expand diagnostic capacities, such is not the case in resource-limited settings of low- to medium-income countries. Aiming at developing cost-effective viral load detection systems for point-of-care COVID-19 diagnostics in resource-limited and resource-rich settings alike, we report the development of an integrated modular centrifugal microfluidic platform to perform loop-mediated isothermal amplification (LAMP) of viral RNA directly from heat-inactivated nasopharyngeal swab samples. The discs were pre-packed with dried n-benzyl-n-methylethanolamine modified agarose beads used to selectively remove primer dimers, inactivate the reaction post-amplification and allowing enhanced fluorescence detection via a smartphone camera. Sample-to-answer analysis within 1 hour from sample collection and a detection limit of approximately 100 RNA copies in 10 \u03bcL reaction volume were achieved. The platform was validated with a panel of 162 nasopharyngeal swab samples collected from patients with COVID-19 symptoms, providing a sensitivity of 96.6% (82.2-99.9%, 95% CI) for samples with Ct values below 26 and a specificity of 100% (90-100%, 95% CI), thus being fit-for-purpose to diagnose patients with a high risk of viral transmission. These results show significant promise towards bringing routine point-of-care COVID-19 diagnostics to resource-limited settings.", "doi": "10.1039/d1lc00266j", "pmid": "34114589", "labels": {"Research Area: Diagnostics for virus": null, "Funder: KAW/SciLifeLab": null, "Funder: H2020": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-06T14:40:58.154Z", "modified": "2021-08-23T12:18:50.531Z"}, {"entity": "publication", "iuid": "03634cc797f44a70b47acd4b13e62fd1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/03634cc797f44a70b47acd4b13e62fd1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/03634cc797f44a70b47acd4b13e62fd1"}}, "title": "Correction to: Perceptions and effects of COVID-19 related information in Denmark and Sweden - a web-based survey about COVID-19 and social media.", "authors": [{"family": "Stjernsw\u00e4rd", "given": "Sigrid", "initials": "S", "orcid": "0000-0002-7152-9206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cda8ee3ae8564252aa6ffe2ab219ada8.json"}}, {"family": "Ivert", "given": "Anna-Karin", "initials": "AK", "orcid": "0000-0001-7749-9549", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fec7c74c7fa4df4849474c8c3a9e8a7.json"}}, {"family": "Glasdam", "given": "Stinne", "initials": "S", "orcid": "0000-0002-0893-3054", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c56787745d04e05ad85e53ce8df6061.json"}}], "type": "published erratum", "published": "2021-08-07", "journal": {"title": "Z Gesundh Wiss", "issn": "2198-1833", "pages": "1", "issn-l": null}, "abstract": "[This corrects the article DOI: 10.1007/s10389-021-01539-5.].", "doi": "10.1007/s10389-021-01642-7", "pmid": "34395176", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "1642"}, {"db": "pmc", "key": "PMC8346338"}], "notes": [], "created": "2021-08-17T06:43:31.753Z", "modified": "2021-08-17T06:43:31.856Z"}, {"entity": "publication", "iuid": "b444c703d7a148c4883271a70fd7e27f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b444c703d7a148c4883271a70fd7e27f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b444c703d7a148c4883271a70fd7e27f"}}, "title": "Voters' view of leaders during the Covid-19 crisis: Quantitative analysis of keyword descriptions provides strength and direction of evaluations.", "authors": [{"family": "Fred\u00e9n", "given": "Annika", "initials": "A", "orcid": "0000-0003-0820-8626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c0b021ac0de4dfdbc719292533683d6.json"}}, {"family": "Sikstr\u00f6m", "given": "Sverker", "initials": "S"}], "type": "journal article", "published": "2021-08-06", "journal": {"title": "Soc Sci Q", "issn": "0038-4941", "issn-l": null}, "abstract": "Previous research suggests that governments usually gain support during crises such as the Covid-19. However, these findings are based on rating scales that only allow us to measure the strength of this support. This article proposes a new measure of how voters evaluate Prime Ministers (PM) by asking for descriptive keywords that are analyzed by natural language processing.\n\nBy collecting a representative sample of citizens' own key words describing their PM in 15 countries in Europe during the outbreak of Covid-19, and analyzing these by latent semantic analysis and a multiple OLS regression, we could quantify the strength and direction of voters' view.\n\nThe strength analysis supported previous studies that describing the PM with positive words was strongly associated with vote intention. Furthermore, a change in the direction of the attitudes from \"good\" to \"honest\" was found. A new finding was that the pandemic was associated with an increase in polarization.\n\nThe keyword evaluation analysis provides opportunities of evaluating both strength and direction of voters' view of their PM, where we show new results related to increased polarization and shift in the direction of attitudes.", "doi": "10.1111/ssqu.13036", "pmid": "34548706", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "SSQU13036"}, {"db": "pmc", "key": "PMC8447460"}], "notes": [], "created": "2021-10-27T05:13:02.985Z", "modified": "2021-10-27T05:13:03.055Z"}, {"entity": "publication", "iuid": "76fa32053cc14e888d63db4413367003", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76fa32053cc14e888d63db4413367003.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76fa32053cc14e888d63db4413367003"}}, "title": "Secondary bacterial infections and antimicrobial resistance in COVID-19: comparative evaluation of pre-pandemic and pandemic-era, a retrospective single center study.", "authors": [{"family": "Karata\u015f", "given": "Mustafa", "initials": "M", "orcid": "0000-0002-2464-0593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe5e7d7c255f4b6394d7d0712c8af986.json"}}, {"family": "Ya\u015far-Duman", "given": "Melike", "initials": "M", "orcid": "0000-0001-8913-2314", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eee2e7153be4128987516582c5f82a5.json"}}, {"family": "T\u00fcnger", "given": "Alper", "initials": "A", "orcid": "0000-0002-1644-8833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2370d67703347be8fb05a1fc5c3fabe.json"}}, {"family": "\u00c7illi", "given": "Feriha", "initials": "F", "orcid": "0000-0003-3993-3396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0de7edbbcdda42f5a81352fb68d95bfe.json"}}, {"family": "Aydemir", "given": "\u015e\u00f6hret", "initials": "\u015e", "orcid": "0000-0001-8354-9100", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf04dbb9c5404c268f1a5b2497bbe24d.json"}}, {"family": "\u00d6zenci", "given": "Volkan", "initials": "V", "orcid": "0000-0002-8069-4027", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04a5e899bc05457496095b831df1391a.json"}}], "type": "journal article", "published": "2021-08-05", "journal": {"title": "Ann Clin Microbiol Antimicrob", "issn": "1476-0711", "volume": "20", "issue": "1", "pages": "51", "issn-l": null}, "abstract": "In this study, we aimed to evaluate the epidemiology and antimicrobial resistance (AMR) patterns of bacterial pathogens in COVID-19 patients and to compare the results with control groups from the pre-pandemic and pandemic era.\n\nMicrobiological database records of all the COVID-19 diagnosed patients in the Ege University Hospital between March 15, 2020, and June 15, 2020, evaluated retrospectively. Patients who acquired secondary bacterial infections (SBIs) and bacterial co-infections were analyzed. Etiology and AMR data of the bacterial infections were collected. Results were also compared to control groups from pre-pandemic and pandemic era data.\n\nIn total, 4859 positive culture results from 3532 patients were analyzed. Fifty-two (3.59%) patients had 78 SBIs and 38 (2.62%) patients had 45 bacterial co-infections among 1447 COVID-19 patients. 22/85 (25.88%) patients died who had bacterial infections. The respiratory culture-positive sample rate was 39.02% among all culture-positive samples in the COVID-19 group. There was a significant decrease in extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales (8.94%) compared to samples from the pre-pandemic (20.76%) and pandemic era (20.74%) (p = 0.001 for both comparisons). Interestingly, Acinetobacter baumannii was the main pathogen in the respiratory infections of COVID-19 patients (9.76%) and the rate was significantly higher than pre-pandemic (3.49%, p < 0.002) and pandemic era control groups (3.11%, p < 0.001).\n\nDue to the low frequency of SBIs reported during the ongoing pandemic, a more careful and targeted antimicrobial prescription should be taken. While patients with COVID-19 had lower levels of ESBL-producing Enterobacterales, the frequency of multidrug-resistant (MDR) A. baumannii is higher.", "doi": "10.1186/s12941-021-00454-7", "pmid": "34353332", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12941-021-00454-7"}, {"db": "pmc", "key": "PMC8340813"}], "notes": [], "created": "2021-08-11T14:42:06.234Z", "modified": "2021-08-11T14:42:06.390Z"}, {"entity": "publication", "iuid": "bf9ea7246bbc4f0bacd9505b617d039e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf9ea7246bbc4f0bacd9505b617d039e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf9ea7246bbc4f0bacd9505b617d039e"}}, "title": "Immunity to SARS-CoV-2 induced by infection or vaccination.", "authors": [{"family": "Castro Dopico", "given": "Xaquin", "initials": "X", "orcid": "0000-0002-9005-6774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/354c91b234fd4a039f85c13e7e4209c1.json"}}, {"family": "Ols", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-9784-7176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35eb7b8de6434661a729bab979f26c7d.json"}}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K", "orcid": "0000-0001-7679-9494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02d4d3d9ccc547f7ab18ba69493f6a34.json"}}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB", "orcid": "0000-0001-7255-9047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/891aa9ca3f604b7396a14d65a33c2187.json"}}], "type": "journal article", "published": "2021-08-05", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null}, "abstract": "Adaptive immune responses play critical roles in viral clearance and protection against re-infection, and SARS-CoV-2 is no exception. What is exceptional, is the rapid characterization of the immune response to the virus performed by researchers during the first 20 months of the pandemic. This has given us a more detailed understanding about SARS-CoV-2 than we have about many viruses that have been with us for a long time. Furthermore, effective COVID-19 vaccines were developed in record time, and their rollout worldwide is already making a significant difference, although major challenges remain in terms of equal access. The pandemic has engaged scientists and the public alike, and terms such as seroprevalence, neutralizing antibodies, antibody escape and vaccine certificates have become familiar to a broad community. Here, we review key findings concerning B cell and antibody (Ab) responses to SARS-CoV-2, focusing on non-severe cases and anti-spike (S) Ab responses in particular, the latter being central to protective immunity induced by infection or vaccination. The emergence of viral variants that have acquired mutations in S acutely highlights the need for continued characterization of both emerging variants and Ab responses against these during the evolving pathogen-immune system arms race.", "doi": "10.1111/joim.13372", "pmid": "34352148", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-08-06T08:55:00.572Z", "modified": "2021-08-06T08:55:00.672Z"}, {"entity": "publication", "iuid": "8918d87280614988a89a6fe124e69d32", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8918d87280614988a89a6fe124e69d32.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8918d87280614988a89a6fe124e69d32"}}, "title": "Higher rate of SARS-CoV-2 IgG seropositivity in hospital-based healthcare workers compared to elderly care staff in a Swedish low-prevalence region: a cross-sectional study.", "authors": [{"family": "Ocias", "given": "Lukas Frans", "initials": "LF"}, {"family": "Skogstam", "given": "Anna", "initials": "A"}, {"family": "Kjerstadius", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Lundin", "given": "Fredrik", "initials": "F"}, {"family": "Tevell", "given": "Staffan", "initials": "S", "orcid": "0000-0002-9213-9274", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12b1a3e80af94b3e8bbb3abbe247ecd0.json"}}], "type": "journal article", "published": "2021-08-05", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": "53", "issue": "12", "pages": "920-929"}, "abstract": "Previous seroprevalence studies have demonstrated higher anti-SARS-CoV-2 IgG seroprevalence in healthcare workers (HCWs) than in the background population during the first phase of the 2020 COVID-19 pandemic. These studies, however, focussed mainly on hospital employees.\r\n\r\nTo perform a cross-sectional study comparing the seroprevalence of hospital-based HCWs with those employed in elderly care (home care and nursing homes).\r\n\r\nEmployees (n = 4955) in the county of V\u00e4rmland, Sweden, were recruited between weeks 27 and 42 and tested for IgG antibodies against SARS-CoV-2. Serological results were combined with self-reported questionnaire data.\r\n\r\nIgG seroprevalence was 5.7% in the total group of HCWs, and was higher among those employed in hospital-based healthcare than among those working in elderly care (8.4% vs. 3.7%, p < .001). Being employed as an assistant nurse, working in a COVID-19 unit, and being exposed via co-workers or private acquaintances were all associated with IgG seropositivity.\r\n\r\nThe difference in seroprevalence between HCWs in the two settings suggests that not only the profession but also factors in the workplace environment may be of importance. As all studied exposures were associated with IgG seropositivity, and asymptomatic infection was detected in 7.5% of participants, preventing outbreaks among HCWs is challenging. Adequate use of personal protective equipment when working with patients regardless of COVID-19 status, source control in situations with co-workers in which distancing is not possible, and routines enabling symptomatic staff to isolate pending PCR results are required to prevent healthcare-associated outbreaks of COVID-19.", "doi": "10.1080/23744235.2021.1959949", "pmid": "34350813", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-06T08:55:23.783Z", "modified": "2021-11-18T13:25:45.879Z"}, {"entity": "publication", "iuid": "48eba88ae335446a9743f6fd56902d34", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/48eba88ae335446a9743f6fd56902d34.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/48eba88ae335446a9743f6fd56902d34"}}, "title": "Role of potential COVID-19 immune system associated genes and the potential pathways linkage with type-2 diabetes.", "authors": [{"family": "Helmi", "given": "Nawal", "initials": "N"}, {"family": "Alammari", "given": "Dalia", "initials": "D"}, {"family": "Mobashir", "given": "Mohammad", "initials": "M"}], "type": "journal article", "published": "2021-08-04", "journal": {"title": "Comb Chem High Throughput Screen", "issn": "1875-5402", "issn-l": null}, "abstract": "Coronavirus is an enveloped positive-sense RNA virus and is characterized by club-like spikes projecting from its surface which is commonly associated with acute respiratory infections in humans but its ability to infect multiple host species and multiple diseases brings it to a complex pathogen group. The frequent interactions of wild animals with humans it is more prevalent a common source of such infections and SARS-CoV and MERS-CoV are the zoonotic pathogens among the leading cause of severe respiratory diseases in humans.\n\nThe major purpose of this study was to study the gene expression profiling for those human samples which are infected with coronavirus or uninfected and compare the differential expression patterns and its functional impact.\n\nFor this purpose, the previously studied samples have been collected from public database and the study had been performed and it includes gene expression analysis, pathway analysis, and the network-level understanding. The analysis presents the data for the differentially expressed genes, enriched pathways and the networks for the potential genes and gene sets. In terms of gene expression and the linkage of COVID-19 with type-2 diabetes.\n\nWe observe that there are a large number of genes which show altered gene expression pattern than the normal for coronavirus infection while in terms of pathways it appears that there are few sets of functions which are affected due to altered gene expression and they infer to infection, inflammation, and the immune system.\n\nBased on our study, we conclude that the potential genes which are affected due to infection are NFKBIA, MYC, FOXO3, BIRC3, ICAM1, IL8, CXCL1/2/5, GADD45A, RELB, SGK1, AREG, BBC3, DDIT3/4, EGR1, MTHFD2, and SESN2 and the functional changes are mainly associated with these pathways TNF, cytokine, NF-kB, TLR, TCR, BCR, Foxo, and TGF signaling pathways are among them and there are additional pathways such as hippo signaling, apoptosis, estrogen signaling, regulating pluropotency of stem cells, ErbB, Wnt, p53, cAMP, MAPK, PI3K-AKT, oxidative phosphorylation, protein processing in endoplasmic reticulum, prolactin signaling, adipocytokine, neurotrophine signaling, and longevity regulating pathways. SMARCD3, PARL, GLIPR1, STAT2, PMAIP1, GP1BA, and TOX genes and PI3K-Akt, focal adhesion, Foxo, phagosome, adrenergic, osteoclast differentiation, platelet activation, insulin, cytokine-cytokine interaction, apoptosis, ECM, JAK-STAT, and oxytocine signaling appear as the linkage between COVID-19 and Type-2 diabetes.", "doi": "10.2174/1386207324666210804124416", "pmid": "34348612", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "CCHTS-EPUB-117038"}], "notes": [], "created": "2021-08-06T09:42:09.565Z", "modified": "2021-08-06T09:42:27.505Z"}, {"entity": "publication", "iuid": "5f9fb8c55117495fae2f3a7f43e2ea34", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f9fb8c55117495fae2f3a7f43e2ea34.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f9fb8c55117495fae2f3a7f43e2ea34"}}, "title": "Risk Perception and Protective Behavior in the Context of COVID-19: a Qualitative Exploration.", "authors": [{"family": "Siddiqui", "given": "Salma", "initials": "S"}, {"family": "Qamar", "given": "Azher Hameed", "initials": "AH", "orcid": "0000-0002-6137-6533", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27dff98f20e04eb3896dfab7e775c56f.json"}}], "type": "journal article", "published": "2021-08-04", "journal": {"title": "Asian Bioeth Rev", "issn": "1793-9453", "pages": "1-20", "issn-l": null}, "abstract": "As a result of the devastating health effects of the COVID-19 outbreak, the lockdown has been considered a safety measure in many countries. In Pakistan, the first case of COVID-19 was reported in February 2020. The purpose of this qualitative study was to investigate people's risk perception and protective behavior during the lockdown. Twenty-two (22) participants from eight big cities across Pakistan were interviewed. A six-step reflective thematic analysis was used for data analysis. The study focused on risk perception and protective behaviors. Our main analytical goal was to understand how risk perception shapes human behavior in the context of lockdown, pandemic-related information flow, and corresponding meaning-making. The study revealed that people influenced by information and advice campaigns form a perception of risk that has shaped their protective behavior. They used familiar means of coping with distress, including the search for strength through religious belief practices and following the precautions recommended by health professionals through the media.", "doi": "10.1007/s41649-021-00181-3", "pmid": "34367345", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "181"}, {"db": "pmc", "key": "PMC8335444"}], "notes": [], "created": "2021-08-11T14:34:57.786Z", "modified": "2021-08-11T14:36:16.611Z"}, {"entity": "publication", "iuid": "8050b697856f485ab35747b02497d14a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8050b697856f485ab35747b02497d14a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8050b697856f485ab35747b02497d14a"}}, "title": "Insomnia, anxiety, and depression during the COVID-19 pandemic: an international collaborative study.", "authors": [{"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Chung", "given": "Frances", "initials": "F"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "Penzel", "given": "Thomas", "initials": "T"}, {"family": "Ivers", "given": "Hans", "initials": "H"}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK"}, {"family": "Chan", "given": "Ngan Yin", "initials": "NY"}, {"family": "Merikanto", "given": "Ilona", "initials": "I"}, {"family": "Mota-Rolim", "given": "Sergio", "initials": "S"}, {"family": "Mac\u00eado", "given": "Tain\u00e1", "initials": "T"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L"}, {"family": "L\u00e9ger", "given": "Damien", "initials": "D"}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y"}, {"family": "Plazzi", "given": "Giuseppe", "initials": "G"}, {"family": "Nadorff", "given": "Michael R", "initials": "MR"}, {"family": "Bolstad", "given": "Courtney J", "initials": "CJ"}, {"family": "Sieminski", "given": "Mariusz", "initials": "M"}, {"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J"}, {"family": "Inoue", "given": "Yuchi", "initials": "Y"}, {"family": "Han", "given": "Fang", "initials": "F"}, {"family": "Espie", "given": "Colin A", "initials": "CA"}], "type": "journal article", "published": "2021-08-04", "journal": {"title": "Sleep Med", "issn": "1878-5506", "volume": "87", "pages": "38-45", "issn-l": null}, "abstract": "The COVID-19 pandemic has produced unprecedented changes in social, work, and leisure activities, which all have had major impact on sleep and psychological well-being. This study documented the prevalence of clinical cases of insomnia, anxiety, and depression and selected risk factors (COVID-19, confinement, financial burden, social isolation) during the first wave of the pandemic in 13 countries throughout the world.\n\nInternational, multi-center, harmonized survey of 22 330 adults (mean age = 41.9 years old, range 18-95; 65.6% women) from the general population in 13 countries and four continents. Participants were invited to complete a standardized web-based survey about sleep and psychological symptoms during the first wave of the COVID-19 pandemic from May to August 2020.\n\nClinical insomnia symptoms were reported by 36.7% (95% CI, 36.0-37.4) of respondents and 17.4% (95% CI, 16.9-17.9) met criteria for a probable insomnia disorder. There were 25.6% (95% CI, 25.0-26.2) with probable anxiety and 23.1% (95% CI, 22.5-23.6) with probable depression. Rates of insomnia symptoms (>40%) and insomnia disorder (>25%) were significantly higher in women, younger age groups, and in residents of Brazil, Canada, Norway, Poland, USA, and United Kingdom compared to residents from Asian countries (China and Japan, 8% for disorder and 22%-25% for symptoms) (all Ps < 0.01). Proportions of insomnia cases were significantly higher among participants who completed the survey earlier in the first wave of the pandemic relative to those who completed it later. Risks of insomnia were higher among participants who reported having had COVID-19, who reported greater financial burden, were in confinement for a period of four to five weeks, and living alone or with more than five people in same household. These associations remained significant after controlling for age, sex, and psychological symptoms.\n\nInsomnia, anxiety, and depression were very prevalent during the first wave of the COVID-19 pandemic. Public health prevention programs are needed to prevent chronicity and reduce long-term adverse outcomes associated with chronic insomnia and mental health problems.", "doi": "10.1016/j.sleep.2021.07.035", "pmid": "34508986", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1389-9457(21)00419-6"}], "notes": [], "created": "2021-09-13T06:31:15.919Z", "modified": "2021-09-13T06:31:15.942Z"}, {"entity": "publication", "iuid": "1180428124864f828411a81b51033272", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1180428124864f828411a81b51033272.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1180428124864f828411a81b51033272"}}, "title": "Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease.", "authors": [{"family": "Ricke-Hoch", "given": "Melanie", "initials": "M", "orcid": "0000-0001-5479-2275", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cd10380b93048dbae752276651ca2d3.json"}}, {"family": "Stelling", "given": "Elisabeth", "initials": "E"}, {"family": "Lasswitz", "given": "Lisa", "initials": "L"}, {"family": "Gunesch", "given": "Antonia P", "initials": "AP"}, {"family": "Kasten", "given": "Martina", "initials": "M"}, {"family": "Zapatero-Belinch\u00f3n", "given": "Francisco J", "initials": "FJ"}, {"family": "Brogden", "given": "Graham", "initials": "G"}, {"family": "Gerold", "given": "Gisa", "initials": "G", "orcid": "0000-0002-1326-5038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39af3df98cf14f96baa155798617841b.json"}}, {"family": "Pietschmann", "given": "Thomas", "initials": "T"}, {"family": "Montiel", "given": "Virginie", "initials": "V"}, {"family": "Balligand", "given": "Jean-Luc", "initials": "JL"}, {"family": "Facciotti", "given": "Federica", "initials": "F"}, {"family": "Hirsch", "given": "Emilio", "initials": "E"}, {"family": "Gausepohl", "given": "Thomas", "initials": "T", "orcid": "0000-0003-1669-5911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd75a34037c14a1da4a85449ece2d242.json"}}, {"family": "Elbahesh", "given": "Husni", "initials": "H", "orcid": "0000-0003-1243-0967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822945b93dea44058ffd0881204ff742.json"}}, {"family": "Rimmelzwaan", "given": "Guus F", "initials": "GF"}, {"family": "H\u00f6fer", "given": "Anne", "initials": "A"}, {"family": "K\u00fchnel", "given": "Mark P", "initials": "MP"}, {"family": "Jonigk", "given": "Danny", "initials": "D"}, {"family": "Eigendorf", "given": "Julian", "initials": "J"}, {"family": "Tegtbur", "given": "Uwe", "initials": "U"}, {"family": "Mink", "given": "Lena", "initials": "L"}, {"family": "Scherr", "given": "Michaela", "initials": "M"}, {"family": "Illig", "given": "Thomas", "initials": "T"}, {"family": "Schambach", "given": "Axel", "initials": "A"}, {"family": "Pfeffer", "given": "Tobias J", "initials": "TJ"}, {"family": "Hilfiker", "given": "Andres", "initials": "A"}, {"family": "Haverich", "given": "Axel", "initials": "A"}, {"family": "Hilfiker-Kleiner", "given": "Denise", "initials": "D"}], "type": "journal article", "published": "2021-08-04", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "8", "pages": "e0255335", "issn-l": "1932-6203"}, "abstract": "The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds that risk-factors for severe COVID-19 disease courses, i.e. male sex, older age and sedentary life style are associated with higher prostaglandin E2 (PGE2) serum levels in blood samples from unaffected subjects. In COVID-19 patients, PGE2 blood levels are markedly elevated and correlate positively with disease severity. SARS-CoV-2 induces PGE2 generation and secretion in infected lung epithelial cells by upregulating cyclo-oxygenase (COX)-2 and reducing the PG-degrading enzyme 15-hydroxyprostaglandin-dehydrogenase. Also living human precision cut lung slices (PCLS) infected with SARS-CoV-2 display upregulated COX-2. Regular exercise in aged individuals lowers PGE2 serum levels, which leads to increased Paired-Box-Protein-Pax-5 (PAX5) expression, a master regulator of B-cell survival, proliferation and differentiation also towards long lived memory B-cells, in human pre-B-cell lines. Moreover, PGE2 levels in serum of COVID-19 patients lowers the expression of PAX5 in human pre-B-cell lines. The PGE2 inhibitor Taxifolin reduces SARS-CoV-2-induced PGE2 production. In conclusion, SARS-CoV-2, male sex, old age, and sedentary life style increase PGE2 levels, which may reduce the early anti-viral defense as well as the development of immunity promoting severe disease courses and multiple infections. Regular exercise and Taxifolin treatment may reduce these risks and prevent severe disease courses.", "doi": "10.1371/journal.pone.0255335", "pmid": "34347801", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-08028"}], "notes": [], "created": "2021-08-06T09:44:33.183Z", "modified": "2021-08-06T09:45:32.764Z"}, {"entity": "publication", "iuid": "b172f9cf78d446e6ac4011711b51c1cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b172f9cf78d446e6ac4011711b51c1cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b172f9cf78d446e6ac4011711b51c1cb"}}, "title": "A quantitative analysis of extension and distribution of lung injury in COVID-19: a prospective study based on chest computed tomography.", "authors": [{"family": "Pellegrini", "given": "Mariangela", "initials": "M"}, {"family": "Larina", "given": "Aleksandra", "initials": "A"}, {"family": "Mourtos", "given": "Evangelos", "initials": "E"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Segelsj\u00f6", "given": "Monica", "initials": "M"}, {"family": "Hansen", "given": "Tomas", "initials": "T"}, {"family": "Perchiazzi", "given": "Gaetano", "initials": "G", "orcid": "0000-0001-6834-6399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ef9ffc76bfe47c5afff104e9aaef020.json"}}], "type": "journal article", "published": "2021-08-04", "journal": {"title": "Crit Care", "issn": "1466-609X", "issn-l": "1364-8535", "volume": "25", "issue": "1", "pages": "276"}, "abstract": "Typical features differentiate COVID-19-associated lung injury from acute respiratory distress syndrome. The clinical role of chest computed tomography (CT) in describing the progression of COVID-19-associated lung injury remains to be clarified. We investigated in COVID-19 patients the regional distribution of lung injury and the influence of clinical and laboratory features on its progression.\n\nThis was a prospective study. For each CT, twenty images, evenly spaced along the cranio-caudal axis, were selected. For regional analysis, each CT image was divided into three concentric subpleural regions of interest and four quadrants. Hyper-, normally, hypo- and non-inflated lung compartments were defined. Nonparametric tests were used for hypothesis testing (\u03b1 = 0.05). Spearman correlation test was used to detect correlations between lung compartments and clinical features.\n\nTwenty-three out of 111 recruited patients were eligible for further analysis. Five hundred-sixty CT images were analyzed. Lung injury, composed by hypo- and non-inflated areas, was significantly more represented in subpleural than in core lung regions. A secondary, centripetal spread of lung injury was associated with exposure to mechanical ventilation (p < 0.04), longer spontaneous breathing (more than 14 days, p < 0.05) and non-protective tidal volume (p < 0.04). Positive fluid balance (p < 0.01), high plasma D-dimers (p < 0.01) and ferritin (p < 0.04) were associated with increased lung injury.\n\nIn a cohort of COVID-19 patients with severe respiratory failure, a predominant subpleural distribution of lung injury is observed. Prolonged spontaneous breathing and high tidal volumes, both causes of patient self-induced lung injury, are associated to an extensive involvement of more central regions. Positive fluid balance, inflammation and thrombosis are associated with lung injury. Trial registration Study registered a priori the 20th of March, 2020. Clinical Trials ID NCT04316884.", "doi": "10.1186/s13054-021-03685-4", "pmid": "34348797", "labels": {"Funder: VR": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC8334337"}, {"db": "pii", "key": "10.1186/s13054-021-03685-4"}, {"db": "ClinicalTrials.gov", "key": "NCT04316884"}], "notes": [], "created": "2021-08-06T09:37:31.364Z", "modified": "2023-06-19T15:20:10.287Z"}, {"entity": "publication", "iuid": "f663618c9d864a089fdda6d5102066c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f663618c9d864a089fdda6d5102066c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f663618c9d864a089fdda6d5102066c9"}}, "title": "Update on: high but slightly declining COVID-19 vaccine acceptance and reasons for vaccine acceptance, Finland April to December 2020.", "authors": [{"family": "Hammer", "given": "Charlotte C", "initials": "CC", "orcid": "0000-0002-8288-0288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d188cd00689408ba9d6e336ed590f00.json"}}, {"family": "Cristea", "given": "Veronica", "initials": "V"}, {"family": "Dub", "given": "Timothee", "initials": "T", "orcid": "0000-0002-1819-518X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/034bb5fac60841c180b6a12101d5f4f0.json"}}, {"family": "Sivel\u00e4", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2021-08-03", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "issn-l": null, "volume": "149", "issue": null, "pages": "e187"}, "abstract": "We update our previous insights into COVID-19 vaccine acceptance and hesitancy in Finland. Vaccine acceptance increased from 64% (November/December 2020) to 74% (April 2021). However, there was a group of participants that were preferring to wait to get vaccinated ranging from 6% of over-64-years-olds to 29% of under-30-years-olds. The previously identified enablers convenience (below-50-years-olds), worry about severe disease and protection for oneself (above-50-years-olds) were no longer significantly associated with increased vaccine acceptance. Understanding barriers and enablers behind vaccine acceptance is decisive in ensuring a successful implementation of COVID-19 vaccination programs, which will be key to ending the pandemic.", "doi": "10.1017/S0950268821001680", "pmid": "34340722", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0950268821001680"}, {"db": "pmc", "key": "PMC8367874"}], "notes": [], "created": "2021-08-04T10:09:49.065Z", "modified": "2021-11-18T13:12:31.967Z"}, {"entity": "publication", "iuid": "44faeeb61bf343ae8acc034596145407", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44faeeb61bf343ae8acc034596145407.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44faeeb61bf343ae8acc034596145407"}}, "title": "Publisher Correction: Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice.", "authors": [{"family": "De Gasparo", "given": "Raoul", "initials": "R"}, {"family": "Pedotti", "given": "Mattia", "initials": "M"}, {"family": "Simonelli", "given": "Luca", "initials": "L"}, {"family": "Nickl", "given": "Petr", "initials": "P", "orcid": "0000-0002-4289-0502", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd09e87cae524e40922a94720a978674.json"}}, {"family": "Muecksch", "given": "Frauke", "initials": "F", "orcid": "0000-0002-0132-5101", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94b175929ad14fec921e737bb3dceda7.json"}}, {"family": "Cassaniti", "given": "Irene", "initials": "I"}, {"family": "Percivalle", "given": "Elena", "initials": "E"}, {"family": "Lorenzi", "given": "Julio C C", "initials": "JCC"}, {"family": "Mazzola", "given": "Federica", "initials": "F"}, {"family": "Magr\u00ec", "given": "Davide", "initials": "D", "orcid": "0000-0003-3790-5332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15cedaba7cb3438fad6c71e2a015921e.json"}}, {"family": "Michalcikova", "given": "Tereza", "initials": "T"}, {"family": "Haviernik", "given": "Jan", "initials": "J"}, {"family": "Honig", "given": "Vaclav", "initials": "V", "orcid": "0000-0003-0469-4604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65499eafa5a24320b87d2534f4dcf99a.json"}}, {"family": "Mrazkova", "given": "Blanka", "initials": "B"}, {"family": "Polakova", "given": "Natalie", "initials": "N"}, {"family": "Fortova", "given": "Andrea", "initials": "A"}, {"family": "Tureckova", "given": "Jolana", "initials": "J"}, {"family": "Iatsiuk", "given": "Veronika", "initials": "V"}, {"family": "Di Girolamo", "given": "Salvatore", "initials": "S"}, {"family": "Palus", "given": "Martin", "initials": "M"}, {"family": "Zudova", "given": "Dagmar", "initials": "D"}, {"family": "Bednar", "given": "Petr", "initials": "P"}, {"family": "Bukova", "given": "Ivana", "initials": "I"}, {"family": "Bianchini", "given": "Filippo", "initials": "F"}, {"family": "Mehn", "given": "Dora", "initials": "D"}, {"family": "Nencka", "given": "Radim", "initials": "R"}, {"family": "Strakova", "given": "Petra", "initials": "P"}, {"family": "Pavlis", "given": "Oto", "initials": "O"}, {"family": "Rozman", "given": "Jan", "initials": "J", "orcid": "0000-0002-8035-8904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69dca82b58b8449c8af3e096813d6003.json"}}, {"family": "Gioria", "given": "Sabrina", "initials": "S"}, {"family": "Sammartino", "given": "Jos\u00e8 Camilla", "initials": "JC"}, {"family": "Giardina", "given": "Federica", "initials": "F"}, {"family": "Gaiarsa", "given": "Stefano", "initials": "S"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q", "orcid": "0000-0003-1990-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94a32366862b470eba3a15521b9be290.json"}}, {"family": "Barnes", "given": "Christopher O", "initials": "CO"}, {"family": "Bjorkman", "given": "Pamela J", "initials": "PJ", "orcid": "0000-0002-2277-3990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65549e18865046ac99cfee9f969c2759.json"}}, {"family": "Calzolai", "given": "Luigi", "initials": "L", "orcid": "0000-0002-8474-7974", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e3a67661994a48e28a8279fb27346285.json"}}, {"family": "Piralla", "given": "Antonio", "initials": "A", "orcid": "0000-0002-6062-2579", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af56fb1bc11f43d9861faa71c5b50043.json"}}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Nussenzweig", "given": "Michel C", "initials": "MC"}, {"family": "Bieniasz", "given": "Paul D", "initials": "PD", "orcid": "0000-0002-2368-3719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72f7075120214d4091202cd80ffbe506.json"}}, {"family": "Hatziioannou", "given": "Theodora", "initials": "T"}, {"family": "Prochazka", "given": "Jan", "initials": "J"}, {"family": "Sedlacek", "given": "Radislav", "initials": "R", "orcid": "0000-0002-3352-392X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a1594084f604610a995def1f7a6bdb2.json"}}, {"family": "Robbiani", "given": "Davide F", "initials": "DF", "orcid": "0000-0001-7379-3484", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/941e237779f74a568228c6fe1ee8800c.json"}}, {"family": "Ruzek", "given": "Daniel", "initials": "D", "orcid": "0000-0003-4655-2380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f49c5724719433ea99ebf38a4ff4a58.json"}}, {"family": "Varani", "given": "Luca", "initials": "L", "orcid": "0000-0002-0963-0987", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6c4a4cecfc04659b3b8df2b49430ba6.json"}}], "type": "published erratum", "published": "2021-08-03", "journal": {"title": "Nature", "issn": "1476-4687", "issn-l": "0028-0836"}, "abstract": null, "doi": "10.1038/s41586-021-03719-5", "pmid": "34345019", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41586-021-03719-5"}], "notes": [], "created": "2021-08-06T09:46:27.837Z", "modified": "2021-08-06T09:46:31.466Z"}, {"entity": "publication", "iuid": "49c5fcdae47f44838b85c4eafba0ec1c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49c5fcdae47f44838b85c4eafba0ec1c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49c5fcdae47f44838b85c4eafba0ec1c"}}, "title": "Prevalence and determinants of serum antibodies to SARS-CoV-2 in the general population of the Gardena valley.", "authors": [{"family": "Melotti", "given": "Roberto", "initials": "R", "orcid": "0000-0003-4115-317X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9aadc5f020e74449a6ad0f6b87c55ec1.json"}}, {"family": "Scaggiante", "given": "Federica", "initials": "F"}, {"family": "Falciani", "given": "Michela", "initials": "M"}, {"family": "Weichenberger", "given": "Christian X", "initials": "CX"}, {"family": "Foco", "given": "Luisa", "initials": "L"}, {"family": "Lombardo", "given": "Stefano", "initials": "S"}, {"family": "De Grandi", "given": "Alessandro", "initials": "A"}, {"family": "von Laer", "given": "Dorothee", "initials": "D"}, {"family": "Mahlknecht", "given": "Angelika", "initials": "A"}, {"family": "Pramstaller", "given": "Peter P", "initials": "PP"}, {"family": "Pagani", "given": "Elisabetta", "initials": "E", "orcid": "0000-0002-4008-6756", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1161d621cf434cb8a7a245e40f2fc90f.json"}}, {"family": "Meier", "given": "Horand", "initials": "H"}, {"family": "Gaertner", "given": "Timon", "initials": "T"}, {"family": "Troi", "given": "Christina", "initials": "C"}, {"family": "Mascalzoni", "given": "Deborah", "initials": "D"}, {"family": "Pattaro", "given": "Cristian", "initials": "C"}, {"family": "Mian", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2021-08-03", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": "149", "pages": "e194", "issn-l": null}, "abstract": "Estimating the spread of SARS-CoV-2 infection in communities is critical. We surveyed 2244 stratified random sample community members of the Gardena valley, a winter touristic area, amidst the first expansion phase of the COVID-19 pandemic in Europe. We measured agreement between Diasorin and Abbott serum bioassay outputs and the Abbott optimal discriminant threshold of serum neutralisation titres with recursive receiver operating characteristic curve. We analytically adjusted serum antibody tests for unbiased seroprevalence estimate and analysed the determinants of infection with non-response weighted multiple logistic regression. SARS-CoV-2 seroprevalence was 26.9% (95% CI 25.2-28.6) by June 2020. The bioassays had a modest agreement with each other. At a lower threshold than the manufacturer's recommended level, the Abbott assay reflected greater discrimination of serum neutralisation capacity. Seropositivity was associated with place and economic activity, not with sex or age. Symptoms like fever and weakness were age-dependent. SARS-CoV-2 mitigation strategies should account for context in high prevalence areas.", "doi": "10.1017/S0950268821001886", "pmid": "34645534", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0950268821001886"}, {"db": "pmc", "key": "PMC8387688"}], "notes": [], "created": "2021-10-21T05:07:20.223Z", "modified": "2021-10-21T05:07:20.314Z"}, {"entity": "publication", "iuid": "5b8ec62501cf41da8f6c8fdc9837a030", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5b8ec62501cf41da8f6c8fdc9837a030.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5b8ec62501cf41da8f6c8fdc9837a030"}}, "title": "Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients.", "authors": [{"family": "Huckriede", "given": "Joram", "initials": "J"}, {"family": "Anderberg", "given": "Sara B\u00fclow", "initials": "SB"}, {"family": "Morales", "given": "Albert", "initials": "A"}, {"family": "de Vries", "given": "Femke", "initials": "F"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Bergqvist", "given": "Anders", "initials": "A"}, {"family": "Ortiz-P\u00e9rez", "given": "Jos\u00e9 T", "initials": "JT"}, {"family": "Sels", "given": "Jan Willem", "initials": "JW"}, {"family": "Wichapong", "given": "Kanin", "initials": "K"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "van de Poll", "given": "Marcel", "initials": "M"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Luther", "given": "Tomas", "initials": "T"}, {"family": "Reutelingsperger", "given": "Chris", "initials": "C"}, {"family": "de Frutos", "given": "Pablo Garcia", "initials": "PG"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Nicolaes", "given": "Gerry A F", "initials": "GAF"}], "type": "journal article", "published": "2021-08-03", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "15701"}, "abstract": "Coronavirus disease 19 (COVID-19) presents with disease severities of varying degree. In its most severe form, infection may lead to respiratory failure and multi-organ dysfunction. Here we study the levels and evolution of the damage associated molecular patterns (DAMPS) cell free DNA (cfDNA), extracellular histone H3 (H3) and neutrophil elastase (NE), and the immune modulators GAS6 and AXL in relation to clinical parameters, ICU scoring systems and mortality in patients (n = 100) with severe COVID-19. cfDNA, H3, NE, GAS6 and AXL were increased in COVID-19 patients compared to controls. These measures associated with occurrence of clinical events and intensive care unit acquired weakness (ICUAW). cfDNA and GAS6 decreased in time in patients surviving to 30 days post ICU admission. A decrease of 27.2 ng/mL cfDNA during ICU stay associated with patient survival, whereas levels of GAS6 decreasing more than 4.0 ng/mL associated with survival. The presence of H3 in plasma was a common feature of COVID-19 patients, detected in 38% of the patients at ICU admission. NETosis markers cfDNA, H3 and NE correlated well with parameters of tissue damage and neutrophil counts. Furthermore, cfDNA correlated with lowest p/f ratio and a lowering in cfDNA was observed in patients with ventilator-free days.", "doi": "10.1038/s41598-021-95209-x", "pmid": "34344929", "labels": {"Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-95209-x"}], "notes": [], "created": "2021-01-04T09:26:11.519Z", "modified": "2021-08-06T09:49:20.947Z"}, {"entity": "publication", "iuid": "91448b51a4264a738436edb06b9f2b23", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/91448b51a4264a738436edb06b9f2b23.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/91448b51a4264a738436edb06b9f2b23"}}, "title": "Persisting Salivary IgG Against SARS-CoV-2 at 9 Months After Mild COVID-19: A Complementary Approach to Population Surveys.", "authors": [{"family": "Alkharaan", "given": "Hassan", "initials": "H"}, {"family": "Bayati", "given": "Shaghayegh", "initials": "S"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Olsson", "given": "Annika", "initials": "A"}, {"family": "Lindahl", "given": "Karin", "initials": "K"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "Tsilingaridis", "given": "Georgios", "initials": "G"}, {"family": "De Palma", "given": "Patricia", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M", "orcid": "0000-0002-3793-4064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4bc179656eb442f9ac9dc72c8c6841d.json"}}], "type": "journal article", "published": "2021-08-02", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899", "volume": "224", "issue": "3", "pages": "407-414"}, "abstract": "Declining humoral immunity in coronavirus disease 2019 (COVID-19) patients and possible reinfection have raised concern. Mucosal immunity, particularly salivary antibodies, may be short lived although long-term studies are lacking.\r\n\r\nUsing a multiplex bead-based array platform, we investigated antibodies specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins in 256 saliva samples from convalescent patients 1-9 months after symptomatic COVID-19 (n = 74, cohort 1), undiagnosed individuals with self-reported questionnaires (n = 147, cohort 2), and individuals sampled prepandemic (n = 35, cohort 3).\r\n\r\nSalivary IgG antibody responses in cohort 1 (mainly mild COVID-19) were detectable up to 9 months postrecovery, with high correlations between spike and nucleocapsid specificity. At 9 months, IgG remained in blood and saliva in most patients. Salivary IgA was rarely detected at this time point. In cohort 2, salivary IgG and IgA responses were significantly associated with recent history of COVID-19-like symptoms. Salivary IgG tolerated temperature and detergent pretreatments.\r\n\r\nUnlike SARS-CoV-2 salivary IgA that appeared short lived, specific saliva IgG appeared stable even after mild COVID-19, as for blood serology. This noninvasive saliva-based SARS-CoV-2 antibody test with home self-collection may be a complementary alternative to conventional blood serology.", "doi": "10.1093/infdis/jiab256", "pmid": "33978762", "labels": {"Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: High-throughput and high-content serology": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "6274637"}, {"db": "pmc", "key": "PMC8244549"}], "notes": [], "created": "2021-05-17T18:21:49.460Z", "modified": "2021-11-18T15:58:51.138Z"}, {"entity": "publication", "iuid": "dfb5199537e741fdbd4383c7cea19f7c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dfb5199537e741fdbd4383c7cea19f7c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dfb5199537e741fdbd4383c7cea19f7c"}}, "title": "Correlates of intended COVID-19 vaccine acceptance across time and countries: results from a series of cross-sectional surveys.", "authors": [{"family": "Kerr", "given": "John R", "initials": "JR", "orcid": "0000-0002-6606-5507", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7189181d83744a68a99673f7d3a1c28c.json"}}, {"family": "Schneider", "given": "Claudia R", "initials": "CR", "orcid": "0000-0002-6612-5186", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6bbf77e665d4610b7bfe907bc934e9f.json"}}, {"family": "Recchia", "given": "Gabriel", "initials": "G", "orcid": "0000-0002-0210-8635", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e373f0f611e14509b26b643e736506ce.json"}}, {"family": "Dryhurst", "given": "Sarah", "initials": "S", "orcid": "0000-0002-7772-8492", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27179dd2c377475eb5aff23c270ebae4.json"}}, {"family": "Sahlin", "given": "Ullrika", "initials": "U", "orcid": "0000-0002-2932-6253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5af5b2eef6ab49dc8e91d3b41a973242.json"}}, {"family": "Dufouil", "given": "Carole", "initials": "C", "orcid": "0000-0003-2442-4476", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd796b2a505c4549a60d215286f851e0.json"}}, {"family": "Arwidson", "given": "Pierre", "initials": "P"}, {"family": "Freeman", "given": "Alexandra Lj", "initials": "AL", "orcid": "0000-0002-4115-161X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/746c0638712541e78b89fca05787da4e.json"}}, {"family": "van der Linden", "given": "Sander", "initials": "S", "orcid": "0000-0002-0269-1744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e54f2d24c11437d8b032ffab9b6909e.json"}}], "type": "journal article", "published": "2021-08-02", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "8", "pages": "e048025"}, "abstract": "Describe demographical, social and psychological correlates of willingness to receive a COVID-19 vaccine.\r\n\r\nSeries of online surveys undertaken between March and October 2020.\r\n\r\nA total of 25 separate national samples (matched to country population by age and sex) in 12 different countries were recruited through online panel providers (n=25 334).\r\n\r\nReported willingness to receive a COVID-19 vaccination.\r\n\r\nReported willingness to receive a vaccine varied widely across samples, ranging from 63% to 88%. Multivariate logistic regression analyses reveal sex (female OR=0.59, 95% CI 0.55 to 0.64), trust in medical and scientific experts (OR=1.28, 95% CI 1.22 to 1.34) and worry about the COVID-19 virus (OR=1.47, 95% CI 1.41 to 1.53) as the strongest correlates of stated vaccine acceptance considering pooled data and the most consistent correlates across countries. In a subset of UK samples, we show that these effects are robust after controlling for attitudes towards vaccination in general.\r\n\r\nOur results indicate that the burden of trust largely rests on the shoulders of the scientific and medical community, with implications for how future COVID-19 vaccination information should be communicated to maximise uptake.", "doi": "10.1136/bmjopen-2020-048025", "pmid": "34341047", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-048025"}, {"db": "URL", "key": "https://osf.io/p3fau/", "description": "Vaccine data"}, {"db": "URL", "key": "https://osf.io/wdjqx/", "description": "First case and first death per country"}], "notes": [], "created": "2021-08-04T10:09:21.889Z", "modified": "2021-11-19T11:24:29.832Z"}, {"entity": "publication", "iuid": "223875a4ae8849d1acaa4e0e4e94cafb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/223875a4ae8849d1acaa4e0e4e94cafb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/223875a4ae8849d1acaa4e0e4e94cafb"}}, "title": "Clinical characteristics and factors associated with COVID-19-related death and morbidity among hospitalized patients with cancer: a Swedish cohort study.", "authors": [{"family": "Ullgren", "given": "Helena", "initials": "H", "orcid": "0000-0001-5747-853X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8778c04e9c5a45a480e31c662d6b3459.json"}}, {"family": "Camuto", "given": "Angela", "initials": "A"}, {"family": "Rosas", "given": "Sumy", "initials": "S"}, {"family": "Pahnke", "given": "Simon", "initials": "S", "orcid": "0000-0002-3541-2027", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f7056035dab4a0080d35b40977463a8.json"}}, {"family": "Ginman", "given": "Beatrice", "initials": "B"}, {"family": "Enblad", "given": "Gunilla", "initials": "G", "orcid": "0000-0002-0594-724X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06a5b2ff78ac42c79e867240bbc11038.json"}}, {"family": "Glimelius", "given": "Ingrid", "initials": "I"}, {"family": "Fransson", "given": "Per", "initials": "P"}, {"family": "Friesland", "given": "Signe", "initials": "S"}, {"family": "Liu", "given": "Lisa", "initials": "L"}], "type": "journal article", "published": "2021-08-02", "journal": {"title": "Acta Oncol", "issn": "1651-226X", "pages": "1-7", "issn-l": null}, "abstract": "Cancer patients are considered to have a higher risk of dying and developing severe Coronavirus Disease 2019 (COVID-19). To date, there are few studies including co-morbidities and sociodemographic factors when investigating the outcome of COVID-19 in a cohort of cancer patients. In this study, we analyzed cancer patients that have been hospitalized due to COVID-19 during the first wave of the pandemic in Sweden to investigate the impact of COVID-19 on mortality and morbidity.\n\nWe retrospectively collected data on all patients with cancer that were hospitalized due to COVID-19-related symptoms at Uppsala University Hospital and Karolinska University Hospital between 1 March and 31 August 2020. The primary endpoint was COVID-19-related death and the secondary endpoint was to describe COVID-19 severity, defined as symptom severity (grades 0-4) and length of stay (LOS) at the university hospitals.\n\nIn total, 193 patients were included among which 31% died due to COVID-19 and 8% died of other causes. In a multivariable analysis, older age >70 (OR 3.6; 95% CI [1.8-7.3], p < 0.001) and male gender (OR 2.8 [1.4-5.8], p = 0.005) were factors associated with higher likelihood of COVID-19-related death. Several comorbidities \u22652 (OR 5.4 [2.0-14.3], p = 0.001) was independently associated with COVID-19 severity. Treatment with chemotherapy within 90 days prior to COVID-19 diagnosis were not associated with COVID-19-related death or severity.\n\nFactors associated with higher likelihood of COVID-19-related death were older age and male gender. More severe COVID-19 symptoms were seen in patients with multiple comorbidities. We did not see any associations between COVID-19-related death or severity and recent treatment including chemotherapy. In summary, this supports a thorough assessment regarding potential risks with COVID-19 infection in patients with cancer, with a combination of individual risk factors in addition to cancer treatments.", "doi": "10.1080/0284186X.2021.1958005", "pmid": "34334081", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-08-04T10:13:59.528Z", "modified": "2021-08-04T17:02:06.248Z"}, {"entity": "publication", "iuid": "0e0e178f9c3c43bea277a58e46ce4e94", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e0e178f9c3c43bea277a58e46ce4e94.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e0e178f9c3c43bea277a58e46ce4e94"}}, "title": "A phenomics approach for antiviral drug discovery.", "authors": [{"family": "Rietdijk", "given": "Jonne", "initials": "J"}, {"family": "Tampere", "given": "Marianna", "initials": "M"}, {"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Georgiev", "given": "Polina", "initials": "P"}, {"family": "Lapins", "given": "Maris", "initials": "M"}, {"family": "Warpman-Berglund", "given": "Ulrika", "initials": "U"}, {"family": "Spjuth", "given": "Ola", "initials": "O"}, {"family": "Puumalainen", "given": "Marjo-Riitta", "initials": "MR"}, {"family": "Carreras-Puigvert", "given": "Jordi", "initials": "J", "orcid": "0000-0002-7671-3707", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1fc481c38384cf78f24a490ec562e9a.json"}}], "type": "journal article", "published": "2021-08-02", "journal": {"title": "BMC Biol", "issn": "1741-7007", "issn-l": null, "volume": "19", "issue": "1", "pages": "156"}, "abstract": "The emergence and continued global spread of the current COVID-19 pandemic has highlighted the need for methods to identify novel or repurposed therapeutic drugs in a fast and effective way. Despite the availability of methods for the discovery of antiviral drugs, the majority tend to focus on the effects of such drugs on a given virus, its constituent proteins, or enzymatic activity, often neglecting the consequences on host cells. This may lead to partial assessment of the efficacy of the tested anti-viral compounds, as potential toxicity impacting the overall physiology of host cells may mask the effects of both viral infection and drug candidates. Here we present a method able to assess the general health of host cells based on morphological profiling, for untargeted phenotypic drug screening against viral infections.\n\nWe combine Cell Painting with antibody-based detection of viral infection in a single assay. We designed an image analysis pipeline for segmentation and classification of virus-infected and non-infected cells, followed by extraction of morphological properties. We show that this methodology can successfully capture virus-induced phenotypic signatures of MRC-5 human lung fibroblasts infected with human coronavirus 229E (CoV-229E). Moreover, we demonstrate that our method can be used in phenotypic drug screening using a panel of nine host- and virus-targeting antivirals. Treatment with effective antiviral compounds reversed the morphological profile of the host cells towards a non-infected state.\n\nThe phenomics approach presented here, which makes use of a modified Cell Painting protocol by incorporating an anti-virus antibody stain, can be used for the unbiased morphological profiling of virus infection on host cells. The method can identify antiviral reference compounds, as well as novel antivirals, demonstrating its suitability to be implemented as a strategy for antiviral drug repurposing and drug discovery.", "doi": "10.1186/s12915-021-01086-1", "pmid": "34334126", "labels": {"Funder: KAW/SciLifeLab": null, "Research Area: Drug discovery and repurposing of drugs": null, "Funder: VR": null, "Funder: H2020": null, "Category: Biochemistry": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8325993"}, {"db": "pii", "key": "10.1186/s12915-021-01086-1"}], "notes": [], "created": "2021-01-15T14:22:24.952Z", "modified": "2023-06-19T14:38:06.897Z"}, {"entity": "publication", "iuid": "eab92d11331949bda69a729bffc89d35", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eab92d11331949bda69a729bffc89d35.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eab92d11331949bda69a729bffc89d35"}}, "title": "Whether, when and how to extend unemployment benefits: Theory and application to COVID-19.", "authors": [{"family": "Mitman", "given": "Kurt", "initials": "K"}, {"family": "Rabinovich", "given": "Stanislav", "initials": "S"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "J Public Econ", "issn": "0047-2727", "issn-l": null, "volume": "200", "issue": null, "pages": "104447"}, "abstract": "We investigate the optimal response of unemployment insurance to economic shocks, both with and without commitment. The optimal policy with commitment follows a modified Baily-Chetty formula that accounts for job search responses to future UI benefit changes. As a result, the optimal policy with commitment tends to front-load UI, unlike the optimal discretionary policy. In response to shocks intended to mimic those that induced the COVID-19 recession, we find that a large and transitory increase in UI is optimal; and that a policy rule contingent on the change in unemployment, rather than its level, is a good approximation to the optimal policy.", "doi": "10.1016/j.jpubeco.2021.104447", "pmid": "34934254", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0047-2727(21)00083-9"}, {"db": "pmc", "key": "PMC8677353"}], "notes": [], "created": "2022-01-03T15:31:55.461Z", "modified": "2022-11-23T08:54:16.211Z"}, {"entity": "publication", "iuid": "3691196ee38a4d3986720e18d83fe719", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3691196ee38a4d3986720e18d83fe719.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3691196ee38a4d3986720e18d83fe719"}}, "title": "Towards a European strategy to address the COVID-19 pandemic", "authors": [{"family": "Priesemann", "given": "Viola", "initials": "V"}, {"family": "Balling", "given": "Rudi", "initials": "R"}, {"family": "Bauer", "given": "Simon", "initials": "S"}, {"family": "Beutels", "given": "Philippe", "initials": "P"}, {"family": "Valdez", "given": "Andr\u00e9 Calero", "initials": "AC"}, {"family": "Cuschieri", "given": "Sarah", "initials": "S"}, {"family": "Czypionka", "given": "Thomas", "initials": "T"}, {"family": "Dumpis", "given": "Uga", "initials": "U"}, {"family": "Glaab", "given": "Enrico", "initials": "E"}, {"family": "Grill", "given": "Eva", "initials": "E"}, {"family": "Hotulainen", "given": "Pirta", "initials": "P"}, {"family": "Iftekhar", "given": "Emil N", "initials": "EN"}, {"family": "Krutzinna", "given": "Jenny", "initials": "J"}, {"family": "Lionis", "given": "Christos", "initials": "C"}, {"family": "Machado", "given": "Helena", "initials": "H"}, {"family": "Martins", "given": "Carlos", "initials": "C"}, {"family": "McKee", "given": "Martin", "initials": "M"}, {"family": "Pavlakis", "given": "George N", "initials": "GN"}, {"family": "Perc", "given": "Matja\u017e", "initials": "M"}, {"family": "Petelos", "given": "Elena", "initials": "E"}, {"family": "Pickersgill", "given": "Martyn", "initials": "M"}, {"family": "Prainsack", "given": "Barbara", "initials": "B"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}, {"family": "Schernhammer", "given": "Eva", "initials": "E"}, {"family": "Szczurek", "given": "Ewa", "initials": "E"}, {"family": "Tsiodras", "given": "Sotirios", "initials": "S"}, {"family": "Van Gucht", "given": "Steven", "initials": "S"}, {"family": "Willeit", "given": "Peter", "initials": "P"}], "type": "journal-article", "published": "2021-08-00", "journal": {"title": "Lancet", "issn": "0140-6736", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/s0140-6736(21)01808-0", "pmid": null, "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-08-13T12:00:52.537Z", "modified": "2021-08-13T12:01:45.972Z"}, {"entity": "publication", "iuid": "cc82cb507a2a48c2a09b29e2c13b6cce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc82cb507a2a48c2a09b29e2c13b6cce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc82cb507a2a48c2a09b29e2c13b6cce"}}, "title": "The COVID-19 pandemic first wave in Sweden: A national registry study of the effects on pediatric anesthesia and surgery.", "authors": [{"family": "Melander", "given": "Sixten", "initials": "S"}, {"family": "Almstr\u00f6m", "given": "Jimmy", "initials": "J"}, {"family": "Enlund", "given": "Gunnar", "initials": "G", "orcid": "0000-0001-9438-3644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf636f1ef6744d0cbc4008ac4eb2e216.json"}}, {"family": "Frykholm", "given": "Peter", "initials": "P", "orcid": "0000-0001-6402-136X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/674a3d5efa544036a4b46bb6608ea28d.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Paediatr Anaesth", "issn": "1460-9592", "volume": "31", "issue": "8", "pages": "846-853", "issn-l": null}, "abstract": "The COVID-19 pandemic is pushing healthcare systems to their limits. Dramatic reductions in the adult elective surgery are ubiquitous, but corresponding changes in pediatric services are not well described. The Swedish Perioperative Registry contains data on all anesthetic procedures in Sweden, and therefore, provides a unique opportunity to analyze the effect of the pandemic on the pediatric anesthesia capacity on a national level. We hypothesized that there would be a significant reduction in pediatric elective procedures. The aim was to determine the effects on pediatric surgical and anesthetic services during the first wave of the COVID-19 pandemic in Sweden.\n\nFor this retrospective registry cohort study, we extracted all procedures performed on patients <18 years of age in 2020 and 2019. Weeks 12 to 26 of 2020 were defined as the first wave, and data were analyzed according to level of care, type of surgery, procedure code, and emergency or elective surgery.\n\nWe found 7015 fewer procedures during the first wave epoch. Elective cases were reduced by 53.7% while emergency surgery was not significantly affected. During the peak of the first wave in April, there was a 72.8% reduction in elective cases; ENT/maxillofacial surgery showed the greatest reduction (86.7%). The surgical and anesthesia capacity recovered to near-normal levels by the end of June 2020.\n\nWe conclude that the impact of COVID-19 on pediatric surgical procedures in Sweden during the first wave of the pandemic was dramatic, but elective services were restored a few months after the peak.", "doi": "10.1111/pan.14203", "pmid": "33971054", "labels": {"Type: Journal article": null, "Category: Health": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC8242453"}], "notes": [], "created": "2021-05-17T19:02:06.933Z", "modified": "2023-01-13T13:41:44.243Z"}, {"entity": "publication", "iuid": "dbeff85cff3047e0849558961640bf69", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dbeff85cff3047e0849558961640bf69.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dbeff85cff3047e0849558961640bf69"}}, "title": "Significant variations across European centres in implementing recommended guidelines for the paediatric gastroenterology endoscopy suite during the COVID-19 pandemic.", "authors": [{"family": "Athiana", "given": "Ilektra", "initials": "I"}, {"family": "L\u00e9geret", "given": "Corinne", "initials": "C"}, {"family": "Bontems", "given": "Patrick", "initials": "P"}, {"family": "Dall'Oglio", "given": "Luigi", "initials": "L"}, {"family": "De Angelis", "given": "Paola", "initials": "P"}, {"family": "Dias", "given": "Jorge Amil", "initials": "JA"}, {"family": "Hauser", "given": "Bruno", "initials": "B"}, {"family": "Homan", "given": "Matja\u017e", "initials": "M"}, {"family": "Narula", "given": "Priya", "initials": "P"}, {"family": "Norsa", "given": "Lorenzo", "initials": "L"}, {"family": "Oliva", "given": "Salvatore", "initials": "S"}, {"family": "Papadopoulou", "given": "Alexandra", "initials": "A"}, {"family": "Romano", "given": "Claudio", "initials": "C"}, {"family": "Thomson", "given": "Mike", "initials": "M"}, {"family": "Vila-Miravet", "given": "Victor", "initials": "V"}, {"family": "Furlano", "given": "Raoul I", "initials": "RI"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "JPGN Rep", "issn": "2691-171X", "volume": "2", "issue": "3", "pages": "e061", "issn-l": null}, "abstract": "The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) published recommendations regarding protection for the paediatric endoscopist during the coronavirus 2019 (COVID-19) pandemic.The aim of this survey was to investigate whether European paediatric gastroenterology centres applied the recommendations and how this extraordinary situation was handled by the different centres.\n\nTwelve paediatric European gastroenterology centres participated. Nine centres (75%) screened their patients for possible COVID-19 infection before the procedure, the same amount of hospitals changed their practice based on the ESPGHAN recommendations. Six-seven percentage of the centres reduced the staff in the endoscopy suite, 83% of the units used FFP2/3 masks and protective goggles during the procedure and 75% wore waterproof gowns.\n\nUniform guidelines could not be applied by all European hospitals at a certain time point of the viral spread, as different regions of Europe were not only affected differently by COVID-19, but also had different access to personal protective equipment.", "doi": "10.1097/PG9.0000000000000061", "pmid": "34192294", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8162040"}], "notes": [], "created": "2021-07-05T14:27:51.312Z", "modified": "2021-07-05T14:27:51.336Z"}, {"entity": "publication", "iuid": "8caa88f775e948a4bf6725d86b5850f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8caa88f775e948a4bf6725d86b5850f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8caa88f775e948a4bf6725d86b5850f2"}}, "title": "SARS-CoV-2 infections amongst personnel providing home care services for older persons in Stockholm, Sweden.", "authors": [{"family": "Hassan", "given": "S S", "initials": "SS"}, {"family": "Seigerud", "given": "\u00c5", "initials": "\u00c5"}, {"family": "Abdirahman", "given": "R", "initials": "R"}, {"family": "Arroyo M\u00fchr", "given": "L S", "initials": "LS"}, {"family": "Nordqvist Kleppe", "given": "S", "initials": "S"}, {"family": "Pin", "given": "E", "initials": "E"}, {"family": "M\u00e5nberg", "given": "A", "initials": "A"}, {"family": "Hober", "given": "S", "initials": "S"}, {"family": "Nilsson", "given": "P", "initials": "P"}, {"family": "Engstrand", "given": "L", "initials": "L"}, {"family": "Miriam Elfstr\u00f6m", "given": "K", "initials": "K"}, {"family": "Blomqvist", "given": "J", "initials": "J"}, {"family": "Conneryd Lundgren", "given": "K", "initials": "K"}, {"family": "Dillner", "given": "J", "initials": "J", "orcid": "0000-0001-8588-6506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bbb8b0ca5dc648e0b80c1de224b26c69.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": "290", "issue": "2", "pages": "430-436"}, "abstract": "In Sweden, home care services is a major external contact for older persons.\n\nFive home care service companies in Stockholm, Sweden, enrolled 405 employees to a study including serum IgG to SARS-CoV-2 and SARS-CoV-2 virus in throat swabs.\n\n20.1% (81/403) of employees were seropositive, about twice as many as in a simultaneously enrolled reference population (healthcare workers entirely without patient contact, n = 3671; 9.7% seropositivity). 13/379 employees (3.4%) had a current infection (PCR positivity). Amongst these, 5 were also seropositive and 3 were positive with low amounts of virus. High amounts of virus and no antibodies (a characteristic for presymptomatic COVID-19) were present in 5 employees (1.3%).\n\nPersonnel providing home services for older persons appear to be a risk group for SARS-CoV-2. Likely presymptomatic employees can be readily identified by screening. Increased protection of employees and of the older persons they serve is warranted.", "doi": "10.1111/joim.13274", "pmid": "33843090", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Serology": null}, "xrefs": [{"db": "pmc", "key": "PMC8250663"}], "notes": [], "created": "2021-04-13T10:17:03.259Z", "modified": "2021-11-18T16:00:16.404Z"}, {"entity": "publication", "iuid": "7d609c06c1ab41a1bb9dbd6937403c84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d609c06c1ab41a1bb9dbd6937403c84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d609c06c1ab41a1bb9dbd6937403c84"}}, "title": "Risk factors for the delayed viral clearance in COVID-19 patients.", "authors": [{"family": "Chen", "given": "Xiaoping", "initials": "X"}, {"family": "Hu Mt", "given": "Wenjia", "initials": "W"}, {"family": "Yang", "given": "Miao", "initials": "M"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Zhang", "given": "Yongxi", "initials": "Y"}, {"family": "Deng", "given": "Liping", "initials": "L"}, {"family": "Li", "given": "Jinlin", "initials": "J"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Lindahl", "given": "Johanna F", "initials": "JF"}, {"family": "Xiong", "given": "Yong", "initials": "Y", "orcid": "0000-0003-0678-4064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37777ebb9bda45caa57a6c39ebd17ded.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "J Clin Hypertens (Greenwich)", "issn": "1751-7176", "issn-l": "1524-6175", "volume": "23", "issue": "8", "pages": "1483-1489"}, "abstract": "Comorbidities are important for the disease outcome of COVID-19, however, which underlying diseases that contribute the most to aggravate the conditions of COVID-19 patients are still unclear. Viral clearance is the most important laboratory test for defining the recovery of COVID-19 infections. To better understand which underlying diseases that are risk factors for delaying the viral clearance, we retrospectively analyzed 161 COVID-19 clinical cases in the Zhongnan Hospital of Wuhan University, Wuhan, China between January 5 and March 13, 2020. The demographic, clinical and laboratory data, as well as patient treatment records were collected. Univariable and multivariable analysis were performed to explore the association between delayed viral clearance and other factors by using logistic regression. Survival analyses by Kaplan-Meier and Cox regression modeling were employed to identify factors negatively influencing the viral clearance negatively. We found that hypertension and intravenous immunoglobulin adversely affected the time of viral RNA shedding. Hypertension was the most important risk factor to delay the SARS-CoV-2 virus clearance, however, the use of Angiotensin-Converting Enzyme Inhibitors(ACEI)/Angiotensin Receptor Blockers(ARB) did not shorten the time for virus clearance in these hypertensive patients' virus clearance. We conclude that patients having hypertension and intravenous immunoglobulin may delay the viral clearance in COVID-19 patients.", "doi": "10.1111/jch.14308", "pmid": "34171164", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8420571"}], "notes": [], "created": "2021-06-28T18:00:36.406Z", "modified": "2023-06-19T15:32:23.071Z"}, {"entity": "publication", "iuid": "d5aeef1eb51f47d7b04cd19fa4379b3c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5aeef1eb51f47d7b04cd19fa4379b3c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5aeef1eb51f47d7b04cd19fa4379b3c"}}, "title": "Rapid Exclusion of COVID Infection With the Artificial Intelligence Electrocardiogram.", "authors": [{"family": "Attia", "given": "Zachi I", "initials": "ZI"}, {"family": "Kapa", "given": "Suraj", "initials": "S"}, {"family": "Dugan", "given": "Jennifer", "initials": "J"}, {"family": "Pereira", "given": "Naveen", "initials": "N"}, {"family": "Noseworthy", "given": "Peter A", "initials": "PA"}, {"family": "Jimenez", "given": "Francisco Lopez", "initials": "FL"}, {"family": "Cruz", "given": "Jessica", "initials": "J"}, {"family": "Carter", "given": "Rickey E", "initials": "RE"}, {"family": "DeSimone", "given": "Daniel C", "initials": "DC"}, {"family": "Signorino", "given": "John", "initials": "J"}, {"family": "Halamka", "given": "John", "initials": "J"}, {"family": "Chennaiah Gari", "given": "Nikhita R", "initials": "NR"}, {"family": "Madathala", "given": "Raja Sekhar", "initials": "RS"}, {"family": "Platonov", "given": "Pyotr G", "initials": "PG"}, {"family": "Gul", "given": "Fahad", "initials": "F"}, {"family": "Janssens", "given": "Stefan P", "initials": "SP"}, {"family": "Narayan", "given": "Sanjiv", "initials": "S"}, {"family": "Upadhyay", "given": "Gaurav A", "initials": "GA"}, {"family": "Alenghat", "given": "Francis J", "initials": "FJ"}, {"family": "Lahiri", "given": "Marc K", "initials": "MK"}, {"family": "Dujardin", "given": "Karl", "initials": "K"}, {"family": "Hermel", "given": "Melody", "initials": "M"}, {"family": "Dominic", "given": "Paari", "initials": "P"}, {"family": "Turk-Adawi", "given": "Karam", "initials": "K"}, {"family": "Asaad", "given": "Nidal", "initials": "N"}, {"family": "Svensson", "given": "Anneli", "initials": "A"}, {"family": "Fernandez-Aviles", "given": "Francisco", "initials": "F"}, {"family": "Esakof", "given": "Darryl D", "initials": "DD"}, {"family": "Bartunek", "given": "Jozef", "initials": "J"}, {"family": "Noheria", "given": "Amit", "initials": "A"}, {"family": "Sridhar", "given": "Arun R", "initials": "AR"}, {"family": "Lanza", "given": "Gaetano A", "initials": "GA"}, {"family": "Cohoon", "given": "Kevin", "initials": "K"}, {"family": "Padmanabhan", "given": "Deepak", "initials": "D"}, {"family": "Pardo Gutierrez", "given": "Jose Alberto", "initials": "JA"}, {"family": "Sinagra", "given": "Gianfranco", "initials": "G"}, {"family": "Merlo", "given": "Marco", "initials": "M"}, {"family": "Zagari", "given": "Domenico", "initials": "D"}, {"family": "Rodriguez Escenaro", "given": "Brenda D", "initials": "BD"}, {"family": "Pahlajani", "given": "Dev B", "initials": "DB"}, {"family": "Loncar", "given": "Goran", "initials": "G"}, {"family": "Vukomanovic", "given": "Vladan", "initials": "V"}, {"family": "Jensen", "given": "Henrik K", "initials": "HK"}, {"family": "Farkouh", "given": "Michael E", "initials": "ME"}, {"family": "Luescher", "given": "Thomas F", "initials": "TF"}, {"family": "Su Ping", "given": "Carolyn Lam", "initials": "CL"}, {"family": "Peters", "given": "Nicholas S", "initials": "NS"}, {"family": "Friedman", "given": "Paul A", "initials": "PA"}, {"family": "Discover Consortium (Digital and Noninvasive Screening for COVID-19 with AI ECG Repository)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Mayo Clin Proc", "issn": "1942-5546", "volume": "96", "issue": "8", "pages": "2081-2094", "issn-l": "0025-6196"}, "abstract": "To rapidly exclude severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection using artificial intelligence applied to the electrocardiogram (ECG).\n\nA global, volunteer consortium from 4 continents identified patients with ECGs obtained around the time of polymerase chain reaction-confirmed COVID-19 diagnosis and age- and sex-matched controls from the same sites. Clinical characteristics, polymerase chain reaction results, and raw electrocardiographic data were collected. A convolutional neural network was trained using 26,153 ECGs (33.2% COVID positive), validated with 3826 ECGs (33.3% positive), and tested on 7870 ECGs not included in other sets (32.7% positive). Performance under different prevalence values was tested by adding control ECGs from a single high-volume site.\n\nThe area under the curve for detection of acute COVID-19 infection in the test group was 0.767 (95% CI, 0.756 to 0.778; sensitivity, 98%; specificity, 10%; positive predictive value, 37%; negative predictive value, 91%). To more accurately reflect a real-world population, 50,905 normal controls were added to adjust the COVID prevalence to approximately 5% (2657/58,555), resulting in an area under the curve of 0.780 (95% CI, 0.771 to 0.790) with a specificity of 12.1% and a negative predictive value of 99.2%.\n\nInfection with SARS-CoV-2 results in electrocardiographic changes that permit the artificial intelligence-enhanced ECG to be used as a rapid screening test with a high negative predictive value (99.2%). This may permit the development of electrocardiography-based tools to rapidly screen individuals for pandemic control.", "doi": "10.1016/j.mayocp.2021.05.027", "pmid": "34353468", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0025-6196(21)00469-9"}, {"db": "pmc", "key": "PMC8327278"}], "notes": [], "created": "2021-08-11T14:41:45.678Z", "modified": "2021-08-11T14:41:45.689Z"}, {"entity": "publication", "iuid": "b1a31e2f8897420b92fc5124af260100", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1a31e2f8897420b92fc5124af260100.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1a31e2f8897420b92fc5124af260100"}}, "title": "Psychological distress among health professional students during the COVID-19 outbreak", "authors": [{"family": "Li", "given": "Yuchen", "initials": "Y"}, {"family": "Wang", "given": "Yue", "initials": "Y"}, {"family": "Jiang", "given": "Jingwen", "initials": "J"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA", "orcid": "0000-0001-5382-946X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87d1dbec7c6f4942b1db2b999eeb9ece.json"}}, {"family": "Fall", "given": "Katja", "initials": "K", "orcid": "0000-0002-3649-2639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa0adf9b952e4e998c4a2deb07be5907.json"}}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Song", "given": "Huan", "initials": "H"}, {"family": "Lu", "given": "Donghao", "initials": "D"}, {"family": "Zhang", "given": "Wei", "initials": "W", "orcid": "0000-0003-3113-9577", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3cc118af29054fc59971e82c3a711740.json"}}], "type": "journal-article", "published": "2021-08-00", "journal": {"title": "Psychol Med", "issn": "0033-2917", "issn-l": null, "volume": "51", "issue": "11", "pages": "1952-1954"}, "abstract": "Due to the drastic surge of COVID-19 patients, many countries are considering or already graduating health professional students early to aid professional resources. We aimed to assess outbreak-related psychological distress and symptoms of acute stress reaction (ASR) in health professional students and to characterize individuals with potential need for interventions.\n\nWe conducted a prospective cohort study of 1442 health professional students at Sichuan University, China. At baseline (October 2019), participants were assessed for childhood adversity, stressful life events, internet addiction, and family functioning. Using multivariable logistic regression, we examined associations of the above exposures with subsequent psychological distress and ASR in response to the outbreak.\n\nThree hundred and eighty-four (26.63%) participants demonstrated clinically significant psychological distress, while 160 (11.10%) met the criterion for a probable ASR. Individuals who scored high on both childhood adversity and stressful life event experiences during the past year were at increased risks of both distress (ORs 2.00-2.66) and probable ASR (ORs 2.23-3.10), respectively. Moreover, internet addiction was associated with elevated risks of distress (OR 2.05, 95% CI 1.60-2.64) and probable ASR (OR 2.15, 95% CI 1.50-3.10). By contrast, good family functioning was associated with decreased risks of distress (OR 0.43, 95% CI 0.33-0.55) and probable ASR (OR 0.48, 95% CI 0.33-0.69). All associations were independent of baseline psychological distress.\n\nOur findings suggest that COVID-19 related psychological distress and high symptoms burden of ASR are common among health professional students. Extended family and professional support should be considered for vulnerable individuals during these unprecedented times.", "doi": "10.1017/s0033291720001555", "pmid": "32389148", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0033291720001555"}, {"db": "pmc", "key": "PMC7225209"}], "notes": [], "created": "2020-11-25T07:53:07.503Z", "modified": "2021-12-06T13:10:39.089Z"}, {"entity": "publication", "iuid": "e6e339fe0d2a4d418964a3c67e2f51f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6e339fe0d2a4d418964a3c67e2f51f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6e339fe0d2a4d418964a3c67e2f51f8"}}, "title": "Plasma ACE2 species are differentially altered in COVID-19 patients.", "authors": [{"family": "Garc\u00eda-Ayll\u00f3n", "given": "Mar\u00eda-Salud", "initials": "MS"}, {"family": "Moreno-P\u00e9rez", "given": "Oscar", "initials": "O"}, {"family": "Garc\u00eda-Arriaza", "given": "Juan", "initials": "J"}, {"family": "Ramos-Rinc\u00f3n", "given": "Jos\u00e9-Manuel", "initials": "JM"}, {"family": "Cort\u00e9s-G\u00f3mez", "given": "Mar\u00eda-\u00c1ngeles", "initials": "M\u00c1"}, {"family": "Brinkmalm", "given": "Gunnar", "initials": "G"}, {"family": "Andr\u00e9s", "given": "Mariano", "initials": "M"}, {"family": "Le\u00f3n-Ram\u00edrez", "given": "Jos\u00e9-Manuel", "initials": "JM"}, {"family": "Boix", "given": "Vicente", "initials": "V"}, {"family": "Gil", "given": "Joan", "initials": "J"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Esteban", "given": "Mariano", "initials": "M"}, {"family": "Merino", "given": "Esperanza", "initials": "E"}, {"family": "S\u00e1ez-Valero", "given": "Javier", "initials": "J", "orcid": "0000-0001-7480-320X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/848e18c69576492a91a7aa35cee7f632.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "FASEB J", "issn": "1530-6860", "volume": "35", "issue": "8", "pages": "e21745", "issn-l": null}, "abstract": "Studies are needed to identify useful biomarkers to assess the severity and prognosis of COVID-19 disease, caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) virus. Here, we examine the levels of various plasma species of the SARS-CoV-2 host receptor, the angiotensin-converting enzyme 2 (ACE2), in patients at different phases of the infection. Human plasma ACE2 species were characterized by immunoprecipitation and western blotting employing antibodies against the ectodomain and the C-terminal domain, using a recombinant human ACE2 protein as control. In addition, changes in the cleaved and full-length ACE2 species were also examined in serum samples derived from humanized K18-hACE2 mice challenged with a lethal dose of SARS-CoV-2. ACE2 immunoreactivity was present in human plasma as several molecular mass species that probably comprise truncated (70 and 75 kDa) and full-length forms (95, 100, 130, and 170 kDa). COVID-19 patients in the acute phase of infection (n = 46) had significantly decreased levels of ACE2 full-length species, while a truncated 70-kDa form was marginally higher compared with non-disease controls (n = 26). Levels of ACE2 full-length species were in the normal range in patients after a recovery period with an interval of 58-70 days (n = 29), while the 70-kDa species decreased. Levels of the truncated ACE2 species served to discriminate between individuals infected by SARS-CoV-2 and those infected with influenza A virus (n = 17). In conclusion, specific plasma ACE2 species are altered in patients with COVID-19 and these changes normalize during the recovery phase. Alterations in ACE2 species following SARS-CoV-2 infection warrant further investigation regarding their potential usefulness as biomarkers for the disease process and to asses efficacy during vaccination.", "doi": "10.1096/fj.202100051R", "pmid": "34191346", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-07-05T14:25:00.186Z", "modified": "2021-07-05T14:25:00.235Z"}, {"entity": "publication", "iuid": "c9a99007569a4d118c6ea72f0552fe9f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9a99007569a4d118c6ea72f0552fe9f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9a99007569a4d118c6ea72f0552fe9f"}}, "title": "Neurochemical signs of astrocytic and neuronal injury in acute COVID-19 normalizes during long-term follow-up.", "authors": [{"family": "Kanberg", "given": "Nelly", "initials": "N", "orcid": "0000-0002-1064-995X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84d593bfda8f42688e9d4fe713158679.json"}}, {"family": "Simr\u00e9n", "given": "Joel", "initials": "J", "orcid": "0000-0001-5081-6604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00690c8e16a545aea824cdf580837500.json"}}, {"family": "Ed\u00e9n", "given": "Arvid", "initials": "A"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ"}, {"family": "Sundvall", "given": "P\u00e4r-Daniel", "initials": "PD"}, {"family": "Nellg\u00e5rd", "given": "Bengt", "initials": "B"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": "70", "issue": null, "pages": "103512"}, "abstract": "Neurologic manifestations are well-recognized features of coronavirus disease 2019 (COVID-19). However, the longitudinal association of biomarkers reflecting CNS impact and neurological symptoms is not known. We sought to determine whether plasma biomarkers of CNS injury were associated with neurologic sequelae after COVID-19.\n\nPatients with confirmed acute COVID-19 were studied prospectively. Neurological symptoms were recorded during the acute phase of the disease and at six months follow-up, and blood samples were collected longitudinally. Healthy age-matched individuals were included as controls. We analysed plasma concentrations of neurofilament light-chain (NfL), glial fibrillary acidic protein (GFAp), and growth differentiation factor 15 (GDF-15).\n\nOne hundred patients with mild (n = 24), moderate (n = 28), and severe (n = 48) COVID-19 were followed for a median (IQR) of 225 (187-262) days. In the acute phase, patients with severe COVID-19 had higher concentrations of NfL than all other groups (all p < 0\u00b7001), and higher GFAp than controls (p < 0\u00b7001). GFAp was also significantly increased in moderate disease (p < 0\u00b705) compared with controls. NfL (r = 0\u00b753, p < 0\u00b7001) and GFAp (r = 0\u00b739, p < 0\u00b7001) correlated with GDF-15 during the acute phase. After six months, NfL and GFAp concentrations had normalized, with no persisting group differences. Despite this, 50 patients reported persistent neurological symptoms, most commonly fatigue (n = 40), \"brain-fog\" (n = 29), and changes in cognition (n = 25). We found no correlation between persistent neurological symptoms and CNS injury biomarkers in the acute phase.\n\nThe normalization of CNS injury biomarkers in all individuals, regardless of previous disease severity or persisting neurological symptoms, indicates that post COVID-19 neurological sequelae are not accompanied by ongoing CNS injury.\n\nThe Swedish State Support for Clinical Research, SciLifeLab Sweden, and the Knut and Alice Wallenberg Foundation have provided funding for this project.", "doi": "10.1016/j.ebiom.2021.103512", "pmid": "34333238", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pmc", "key": "PMC8320425"}, {"db": "pii", "key": "S2352-3964(21)00305-4"}], "notes": [], "created": "2021-08-04T10:16:45.714Z", "modified": "2023-06-19T14:46:01.082Z"}, {"entity": "publication", "iuid": "6ee34e8dbbdc4f9ea7f914fddabc947a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ee34e8dbbdc4f9ea7f914fddabc947a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ee34e8dbbdc4f9ea7f914fddabc947a"}}, "title": "Natural killer cells and unconventional T cells in COVID-19", "authors": [{"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Ponzetta", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3224-802X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8d6bca49dc24e558ca8f0b3637d7702.json"}}], "type": "journal-article", "published": "2021-08-00", "journal": {"title": "Current Opinion in Virology", "issn": "1879-6257", "issn-l": null, "volume": "49", "issue": null, "pages": "176-182"}, "abstract": null, "doi": "10.1016/j.coviro.2021.06.005", "pmid": "34217135", "labels": {"Type: Review": null, "Funder: VR": null, "Funder: H2020": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [], "notes": [], "created": "2021-06-21T05:55:32.100Z", "modified": "2021-12-12T18:08:46.036Z"}, {"entity": "publication", "iuid": "8425f513719f4c8c92b50fc93ef47bc4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8425f513719f4c8c92b50fc93ef47bc4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8425f513719f4c8c92b50fc93ef47bc4"}}, "title": "Measuring oxygen access: lessons from health facility assessments in Lagos, Nigeria.", "authors": [{"family": "Graham", "given": "Hamish R", "initials": "HR", "orcid": "0000-0003-2461-0463", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d2d23d0b7dc40f3979a4342d3898649.json"}}, {"family": "Olojede", "given": "Omotayo E", "initials": "OE"}, {"family": "Bakare", "given": "Ayobami A", "initials": "AA"}, {"family": "Iuliano", "given": "Agnese", "initials": "A"}, {"family": "Olatunde", "given": "Oyaniyi", "initials": "O"}, {"family": "Isah", "given": "Adamu", "initials": "A"}, {"family": "Osebi", "given": "Adams", "initials": "A"}, {"family": "Ahmed", "given": "Tahlil", "initials": "T"}, {"family": "Uchendu", "given": "Obioma C", "initials": "OC"}, {"family": "Burgess", "given": "Rochelle", "initials": "R", "orcid": "0000-0001-9749-7065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f890d7dbdea04ac09c689b6c612baa26.json"}}, {"family": "McCollum", "given": "Eric", "initials": "E"}, {"family": "Colbourn", "given": "Tim", "initials": "T", "orcid": "0000-0002-6917-6552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2cccce75e4b4602ab197604cb444a0a.json"}}, {"family": "King", "given": "Carina", "initials": "C", "orcid": "0000-0002-6885-6716", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8ac349483b74803a39b937bf149c480.json"}}, {"family": "Falade", "given": "Adegoke G", "initials": "AG"}, {"family": "INSPIRING Project Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "8", "issn-l": "2059-7908"}, "abstract": "The COVID-19 pandemic has highlighted global oxygen system deficiencies and revealed gaps in how we understand and measure 'oxygen access'. We present a case study on oxygen access from 58 health facilities in Lagos state, Nigeria. We found large differences in oxygen access between facilities (primary vs secondary, government vs private) and describe three key domains to consider when measuring oxygen access: availability, cost, use. Of 58 facilities surveyed, 8 (14%) of facilities had a functional pulse oximeter. Oximeters (N=27) were typically located in outpatient clinics (12/27, 44%), paediatric ward (6/27, 22%) or operating theatre (4/27, 15%). 34/58 (59%) facilities had a functional source of oxygen available on the day of inspection, of which 31 (91%) facilities had it available in a single ward area, typically the operating theatre or maternity ward. Oxygen services were free to patients at primary health centres, when available, but expensive in hospitals and private facilities, with the median cost for 2 days oxygen 13 000 (US$36) and 27 500 (US$77) Naira, respectively. We obtained limited data on the cost of oxygen services to facilities. Pulse oximetry use was low in secondary care facilities (32%, 21/65 patients had SpO2 documented) and negligible in private facilities (2%, 3/177) and primary health centres (<1%, 2/608). We were unable to determine the proportion of hypoxaemic patients who received oxygen therapy with available data. However, triangulation of existing data suggested that no facilities were equipped to meet minimum oxygen demands. We highlight the importance of a multifaceted approach to measuring oxygen access that assesses access at the point-of-care and ideally at the patient-level. We propose standard metrics to report oxygen access and describe how these can be integrated into routine health information systems and existing health facility assessment tools.", "doi": "10.1136/bmjgh-2021-006069", "pmid": "34344666", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-006069"}], "notes": [], "created": "2021-08-06T09:49:48.615Z", "modified": "2021-08-06T09:51:35.891Z"}, {"entity": "publication", "iuid": "1d66b977d13240398ce77404977f48d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d66b977d13240398ce77404977f48d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d66b977d13240398ce77404977f48d7"}}, "title": "Low admission protein C levels are a risk factor for disease worsening and mortality in hospitalized patients with COVID-19", "authors": [{"family": "Stanne", "given": "Tara M", "initials": "TM"}, {"family": "Pedersen", "given": "Annie", "initials": "A"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Jern", "given": "Christina", "initials": "C"}], "type": "journal-article", "published": "2021-08-00", "journal": {"title": "Thromb Res", "issn": "0049-3848", "volume": "204", "issue": null, "pages": "13-15", "issn-l": null}, "abstract": null, "doi": "10.1016/j.thromres.2021.05.016", "pmid": "34102452", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [], "notes": [], "created": "2021-06-09T19:02:28.905Z", "modified": "2021-06-10T10:15:42.634Z"}, {"entity": "publication", "iuid": "92f2c01548f4465b9ea64f67b973df7d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/92f2c01548f4465b9ea64f67b973df7d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/92f2c01548f4465b9ea64f67b973df7d"}}, "title": "Impact of the Alpha VOC on disease severity in SARS-CoV-2-positive adults in Sweden", "authors": [{"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-8801-3169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37509c3832244b019b91a1fe2cbe183e.json"}}, {"family": "Bruce", "given": "Daniel", "initials": "D"}, {"family": "Wahlstr\u00f6m", "given": "Erik", "initials": "E", "orcid": "0000-0002-0800-8520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f623177f84a4f4ba85571b106e4cec5.json"}}, {"family": "Walther", "given": "Sten", "initials": "S", "orcid": "0000-0002-3862-2556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f835267776274befa3013a432790de71.json"}}, {"family": "Carnahan", "given": "Moa Rehn, AnnaSara", "initials": "MRA", "orcid": "0000-0002-3940-4323", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ce1cef1f776424a977f2e21f38ff05e.json"}}, {"family": "Andersson", "given": "Emmi", "initials": "E"}, {"family": "Bark", "given": "Anna M Bennet", "initials": "AMB", "orcid": "0000-0003-2704-2625", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa79f4ac2db849368192a91c01cd370a.json"}}, {"family": "Hanberger", "given": "H\u00e5kan", "initials": "H", "orcid": "0000-0002-4199-0229", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ccccceb630874fc5ab7507a313b59039.json"}}], "type": "journal-article", "published": "2021-08-00", "journal": {"title": "J Infect", "issn": "0163-4453", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jinf.2021.08.043", "pmid": "34474056", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "S0163-4453(21)00448-5"}, {"db": "pmc", "key": "PMC8405243"}], "notes": [], "created": "2021-09-06T06:05:00.631Z", "modified": "2021-11-19T11:22:16.947Z"}, {"entity": "publication", "iuid": "fbc72c1d65a94e25b57a9ba3da49b44c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fbc72c1d65a94e25b57a9ba3da49b44c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fbc72c1d65a94e25b57a9ba3da49b44c"}}, "title": "Fostering healthy aging: The interdependency of infections, immunity and frailty.", "authors": [{"family": "Vetrano", "given": "Davide L", "initials": "DL", "orcid": "0000-0002-3099-4830", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0124721bb214413a34c965b6accc64b.json"}}, {"family": "Triolo", "given": "Federico", "initials": "F"}, {"family": "Maggi", "given": "Stefania", "initials": "S"}, {"family": "Malley", "given": "Richard", "initials": "R"}, {"family": "Jackson", "given": "Thomas A", "initials": "TA"}, {"family": "Poscia", "given": "Andrea", "initials": "A", "orcid": "0000-0002-7616-3389", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0a468effc7749f193226a16c27c7b18.json"}}, {"family": "Bernabei", "given": "Roberto", "initials": "R"}, {"family": "Ferrucci", "given": "Luigi", "initials": "L"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Ageing Res Rev", "issn": "1872-9649", "volume": "69", "issue": null, "pages": "101351", "issn-l": "1568-1637"}, "abstract": "Untangling the interdependency of infections, immunity and frailty may help to clarify their roles in the maintenance of health in aging individuals, and the recent COVID-19 pandemic has further highlighted such priority. In this scoping review we aimed to systematically collect the evidence on 1) the impact of common infections such as influenza, pneumonia and varicella zoster on frailty development, and 2) the role played by frailty in the response to immunization of older adults. Findings are discussed under a unifying framework to identify knowledge gaps and outline their clinical and public health implications to foster a healthier aging. Twenty-nine studies (113,863 participants) selected to answer the first question provided a moderately strong evidence of an association between infections and physical as well as cognitive decline - two essential dimensions of frailty. Thirteen studies (34,520 participants) investigating the second aim, showed that frailty was associated with an impaired immune response in older ages, likely due to immunosenescence. However, the paucity of studies, the absence of tools to predict vaccine efficacy, and the lack of studies investigating the efficacy of newer vaccines in presence of frailty, strongly limit the formulation of more personalized immunization strategies for older adults. The current evidence suggests that infections and frailty repeatedly cross each other pathophysiological paths and accelerate the aging process in a vicious circle. Such evidence opens to several considerations. First, the prevention of both conditions pass through a life course approach, which includes several individual and societal aspects. Second, the maintenance of a well-functioning immune system may be accomplished by preventing frailty, and vice versa. Third, increasing the adherence to immunization may delay the onset of frailty and maintain the immune system homeostasis, beyond preventing infections.", "doi": "10.1016/j.arr.2021.101351", "pmid": "33971332", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC9588151"}, {"db": "pii", "key": "S1568-1637(21)00098-2"}], "notes": [], "created": "2021-05-17T19:01:01.504Z", "modified": "2023-06-19T15:29:33.054Z"}, {"entity": "publication", "iuid": "e2899a4f5e3b42c58bf8868d706a73db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2899a4f5e3b42c58bf8868d706a73db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2899a4f5e3b42c58bf8868d706a73db"}}, "title": "Evidence-based public policy making for medicines across countries: findings and implications for the future.", "authors": [{"family": "Godman", "given": "Brian", "initials": "B", "orcid": "0000-0001-6539-6972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e76103610619453b84eab8de36f169cc.json"}}, {"family": "Fadare", "given": "Joseph", "initials": "J", "orcid": "0000-0002-5641-1402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0cd3e8ea7e09469ab822edbaa7f57830.json"}}, {"family": "Kwon", "given": "Hye-Young", "initials": "HY", "orcid": "0000-0001-9772-1354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/935f3f4bd268497aa8bfb936216ab36e.json"}}, {"family": "Dias", "given": "Carolina Zampirolli", "initials": "CZ", "orcid": "0000-0003-2181-4268", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d27ffebfe3ca4a61a66559b3e9927fc9.json"}}, {"family": "Kurdi", "given": "Amanj", "initials": "A", "orcid": "0000-0001-5036-1988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be9bf17786754363929dc0faaae8c323.json"}}, {"family": "Dias God\u00f3i", "given": "Isabella Piassi", "initials": "IP", "orcid": "0000-0002-0568-6625", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6ade8b9c4e94a64add5b0d5b6911a27.json"}}, {"family": "Kibuule", "given": "Dan", "initials": "D", "orcid": "0000-0002-6908-2177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4344137451d04535a5875183b9abc24e.json"}}, {"family": "Hoxha", "given": "Iris", "initials": "I"}, {"family": "Opanga", "given": "Sylvia", "initials": "S"}, {"family": "Saleem", "given": "Zikria", "initials": "Z", "orcid": "0000-0003-3202-6347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/029d4b30cc724148a1225090d3f063ee.json"}}, {"family": "Bochenek", "given": "Tomasz", "initials": "T", "orcid": "0000-0001-9915-7267", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce6242842ee44d19808be95b7a3196d3.json"}}, {"family": "Markovi\u0107-Pekovi\u0107", "given": "Vanda", "initials": "V", "orcid": "0000-0001-8963-5720", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb251c8af64542caa7bb5728b7348ef7.json"}}, {"family": "Mardare", "given": "Ileana", "initials": "I", "orcid": "0000-0002-4725-9808", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d95ddb606d24f5099c75a2e9f8db778.json"}}, {"family": "Kalungia", "given": "Aubrey C", "initials": "AC", "orcid": "0000-0003-2554-1236", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d9dffebafbd4ac2ba111bdb7b32876d.json"}}, {"family": "Campbell", "given": "Stephen", "initials": "S", "orcid": "0000-0002-2328-4136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ca866e1934246d1a368303f3cd026b5.json"}}, {"family": "Allocati", "given": "Eleonora", "initials": "E"}, {"family": "Pisana", "given": "Alice", "initials": "A"}, {"family": "Martin", "given": "Antony P", "initials": "AP", "orcid": "0000-0003-4383-6038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6a0ea83af464d6fa0ec04b3e333fcab.json"}}, {"family": "Meyer", "given": "Johanna C", "initials": "JC", "orcid": "0000-0003-0462-5713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b517b46322e64403aee5b49f60da3ac4.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "J Comp Eff Res", "issn": "2042-6313", "volume": "10", "issue": "12", "pages": "1019-1052", "issn-l": null}, "abstract": "Aim: Global expenditure on medicines is rising up to 6% per year driven by increasing prevalence of non-communicable diseases (NCDs) and new premium priced medicines for cancer, orphan diseases and other complex areas. This is difficult to sustain without reforms. Methods: Extensive narrative review of published papers and contextualizing the findings to provide future guidance. Results: New models are being introduced to improve the managed entry of new medicines including managed entry agreements, fair pricing approaches and monitoring prescribing against agreed guidance. Multiple measures have also successfully been introduced to improve the prescribing of established medicines. This includes encouraging greater prescribing of generics and biosimilars versus originators and patented medicines in a class to conserve resources without compromising care. In addition, reducing inappropriate antibiotic utilization. Typically, multiple measures are the most effective. Conclusion: Multiple measures will be needed to attain and retain universal healthcare.", "doi": "10.2217/cer-2020-0273", "pmid": "34241546", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:59:09.733Z", "modified": "2021-08-06T07:59:09.998Z"}, {"entity": "publication", "iuid": "8af2b1eadc0942f19199db9b059a446b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8af2b1eadc0942f19199db9b059a446b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8af2b1eadc0942f19199db9b059a446b"}}, "title": "Emotions during the Covid-19 pandemic: Fear, anxiety, and anger as mediators between threats and policy support and political actions.", "authors": [{"family": "Renstr\u00f6m", "given": "Emma A", "initials": "EA", "orcid": "0000-0001-6593-2464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c969b46ee25b4276916587537076440c.json"}}, {"family": "B\u00e4ck", "given": "Hanna", "initials": "H"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "J Appl Soc Psychol", "issn": "0021-9029", "issn-l": null, "volume": "51", "issue": "8", "pages": "861-877"}, "abstract": "The Covid-19 pandemic has significantly changed the lives of most people. It has been described as the most severe global health disaster of modern times by the United Nations. No doubt such a major crisis influences what citizens think of different policies, and how they become politically active, not to mention, the forceful emotional experiences that the Covid-19 pandemic brings. This study evaluates how emotions affect support for policies related to restricting the spread of the virus and economic assistance, and how emotions affect intentions to engage politically. In an experiment (N = 1,072), we manipulated emotional reactions to threat by highlighting different aspects of the pandemic. Our findings show that different experimental treatments elicit different emotions, and that fear, anxiety, and anger are all related to policy support and political action intentions, but in different ways. Fear and anger predict support for restrictive policies to limit the spread of the virus, while anxiety predicts support for economic policies. Anger and anxiety, but not fear, increase intentions to engage politically. Hence, we find support for a mechanism where different aspects of the Covid-19 crisis evoke different emotional reactions, which in turn affects policy support and political actions differently.", "doi": "10.1111/jasp.12806", "pmid": "34511637", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "JASP12806"}, {"db": "pmc", "key": "PMC8420191"}], "notes": [], "created": "2021-09-20T06:35:30.177Z", "modified": "2022-11-23T08:54:37.258Z"}, {"entity": "publication", "iuid": "4e9563984492429597bcad2167bf9b30", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4e9563984492429597bcad2167bf9b30.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4e9563984492429597bcad2167bf9b30"}}, "title": "Does the Covid-19 pandemic affect ankle fracture incidence? Moderate decrease in Sweden.", "authors": [{"family": "Rydberg", "given": "Emilia M\u00f6ller", "initials": "EM"}, {"family": "M\u00f6ller", "given": "Michael", "initials": "M"}, {"family": "Ekelund", "given": "Jan", "initials": "J"}, {"family": "Wolf", "given": "Olof", "initials": "O"}, {"family": "Wennergren", "given": "David", "initials": "D"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Acta Orthop", "issn": "1745-3682", "volume": "92", "issue": "4", "pages": "381-384", "issn-l": null}, "abstract": "Background and purpose - While many other countries implemented strict regulations and restrictions for their citizens during the 1st wave of the Covid-19 pandemic, Sweden maintained a more restrained approach. The Swedish Public Health Agency emphasized individual responsibility and pushed for behavioral changes. With strict lockdown a 77% decrease in ankle fracture incidence has been reported. We investigated whether there was a change in the incidence of ankle fractures seen at 7 selected hospitals during the Covid-19 pandemic 2020.Patients and methods - Data on all ankle fractures treated at 7 selected departments during March 15 through June 15, 2020, and for the same period in the preceding 3 years (2017-2019), was retrieved from the Swedish Fracture Register. The number of fractures during the whole period and subsequent 30-day periods were compared between 2020 and 2017-2019, including subgroup analyses of age and sex.Results - The monthly rate of ankle fractures was reduced by 14% in 2020 (139 fractures) compared with 2017-2019 (161 fractures). Women had a 16% decrease and patients aged > 70 years had a 29% decrease. During the 1st 30-day period, a 26% decrease in fractures was seen.Interpretation - During the 1st wave of the Covid-19 pandemic, a moderate decline in the number of ankle fractures was seen. Women and patients aged > 70 years displayed the greatest reduction. The greatest reduction in incidence of fractures was seen during the 1st 30-day period. This indicates greater adherence to government recommendations regarding social distancing in these subgroups and during the 1st month of the pandemic. Changes in ankle fracture incidence may be a measure of lockdown extent.", "doi": "10.1080/17453674.2021.1907517", "pmid": "33821759", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8381968"}], "notes": [], "created": "2021-04-07T10:08:29.763Z", "modified": "2023-01-13T14:44:23.002Z"}, {"entity": "publication", "iuid": "9bdd9b267bc0427a8658fda308767fce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9bdd9b267bc0427a8658fda308767fce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9bdd9b267bc0427a8658fda308767fce"}}, "title": "Diagnostics and management of tuberculosis and COVID-19 in a patient with pneumothorax (clinical case).", "authors": [{"family": "Starshinova", "given": "A", "initials": "A"}, {"family": "Guglielmetti", "given": "L", "initials": "L"}, {"family": "Rzhepishevska", "given": "O", "initials": "O"}, {"family": "Ekaterincheva", "given": "O", "initials": "O"}, {"family": "Zinchenko", "given": "Yu", "initials": "Y"}, {"family": "Kudlay", "given": "D", "initials": "D"}], "type": "case reports", "published": "2021-08-00", "journal": {"title": "J Clin Tuberc Other Mycobact Dis", "issn": "2405-5794", "volume": "24", "pages": "100259", "issn-l": null}, "abstract": "The spread of COVID-19 in countries with high and medium incidence of tuberculosis has led to an increased risk of COVID-19 and tuberculosis co-infection, introducing new diagnostic and therapeutic challenges for the clinician. Hereby we describe a first case where tuberculosis and COVID-19 were diagnosed concomitantly in a Russian patient with pneumothorax. We discuss the challenges associated with the diagnosis and treatment of tuberculosis during the COVID-19 pandemic.", "doi": "10.1016/j.jctube.2021.100259", "pmid": "34235277", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2405-5794(21)00048-6"}, {"db": "pmc", "key": "PMC8245665"}], "notes": [], "created": "2021-08-06T08:23:23.405Z", "modified": "2021-08-06T08:24:22.465Z"}, {"entity": "publication", "iuid": "c47cff1970a64cb7bf6108777ab2b756", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c47cff1970a64cb7bf6108777ab2b756.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c47cff1970a64cb7bf6108777ab2b756"}}, "title": "Determinants for hospitalisations, intensive care unit admission and death among 20,293 reported COVID-19 cases in Portugal, March to April 2020.", "authors": [{"family": "Ricoca Peixoto", "given": "Vasco", "initials": "V"}, {"family": "Vieira", "given": "Andr\u00e9", "initials": "A"}, {"family": "Aguiar", "given": "Pedro", "initials": "P"}, {"family": "Sousa", "given": "Paulo", "initials": "P"}, {"family": "Carvalho", "given": "Carlos", "initials": "C"}, {"family": "Thomas", "given": "Daniel", "initials": "D"}, {"family": "Abrantes", "given": "Alexandre", "initials": "A"}, {"family": "Nunes", "given": "Carla", "initials": "C"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "33", "pages": null}, "abstract": "BackgroundDeterminants of hospitalisation, intensive care unit (ICU) admission and death are still unclear for COVID-19. Few studies have adjusted for confounding for different clinical outcomes including all reported cases within a country.AimWe used routine surveillance data from Portugal to identify risk factors for severe COVID-19 outcomes, and to support risk stratification, public health interventions, and planning of healthcare resources.MethodsWe conducted a retrospective cohort study including 20,293 laboratory-confirmed cases of COVID-19 reported between 1 March and 28 April 2020 through the national epidemiological surveillance system. We calculated absolute risk, relative risk (RR) and adjusted relative risk (aRR) to identify demographic and clinical factors associated with hospitalisation, ICU admission and death using Poisson regressions.ResultsIncreasing age (\u2265 60 years) was the major determinant for all outcomes. Age \u2265 90 years was the strongest determinant of hospital admission (aRR: 6.1), and 70-79 years for ICU (aRR: 10.4). Comorbidities of cardiovascular, immunodeficiency, kidney and lung disease (aRR: 4.3, 2.8, 2.4, 2.0, respectively) had stronger associations with ICU admission, while for death they were kidney, cardiovascular and chronic neurological disease (aRR: 2.9, 2.6, 2.0).ConclusionsOlder age was the strongest risk factor for all severe outcomes. These findings from the early stages of the COVID-19 pandemic support risk-stratified public health measures that should prioritise protecting older people. Epidemiological scenarios and clinical guidelines should consider this, even though under-ascertainment should also be considered.", "doi": "10.2807/1560-7917.ES.2021.26.33.2001059", "pmid": "34414882", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-27T09:44:40.422Z", "modified": "2021-11-18T12:57:57.607Z"}, {"entity": "publication", "iuid": "8912dbd2cef94ff1910c5711bf0b7f83", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8912dbd2cef94ff1910c5711bf0b7f83.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8912dbd2cef94ff1910c5711bf0b7f83"}}, "title": "Comorbidity status of deceased COVID-19 in-patients in Italy.", "authors": [{"family": "Vetrano", "given": "Davide Liborio", "initials": "DL", "orcid": "0000-0002-3099-4830", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0124721bb214413a34c965b6accc64b.json"}}, {"family": "Tazzeo", "given": "Clare", "initials": "C"}, {"family": "Palmieri", "given": "Luigi", "initials": "L"}, {"family": "Marengoni", "given": "Alessandra", "initials": "A"}, {"family": "Zucchelli", "given": "Alberto", "initials": "A"}, {"family": "Lo Noce", "given": "Cinzia", "initials": "C"}, {"family": "Onder", "given": "Graziano", "initials": "G"}, {"family": "Italian National Institute of Health Covid-Mortality Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Aging Clin Exp Res", "issn": "1720-8319", "issn-l": "1594-0667", "volume": "33", "issue": "8", "pages": "2361-2365"}, "abstract": "Most COVID-19-related deaths have occurred in older persons with comorbidities. Specific patterns of comorbidities related to COVID-19 deaths have not been investigated.\n\nA random sample of 6085 individuals in Italy who died in-hospital with confirmed COVID-19 between February and December 2020 were included. Observed to expected (O/E) ratios of disease pairs were computed and logistic regression models were used to determine the association between disease pairs with O/E values \u2265 1.5.\n\nSix pairs of diseases exhibited O/E values \u2265 1.5 and statistically significant higher odds of co-occurrence in the crude and adjusted analyses: (1) ischemic heart disease and atrial fibrillation, (2) atrial fibrillation and heart failure, (3) atrial fibrillation and stroke, (4) heart failure and COPD, (5) stroke and dementia, and (6) type 2 diabetes and obesity.\n\nIn those deceased in-hospital due to COVID-19 in Italy, disease combinations defined by multiple cardio-respiratory, metabolic, and neuropsychiatric diseases occur more frequently than expected. This finding indicates a need to investigate the possible role of these clinical profiles in the chain of events that lead to death in individuals who have contracted SARS-CoV-2.", "doi": "10.1007/s40520-021-01914-y", "pmid": "34169447", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8224257"}, {"db": "pii", "key": "10.1007/s40520-021-01914-y"}], "notes": [], "created": "2021-06-28T18:14:36.919Z", "modified": "2023-06-19T15:29:44.970Z"}, {"entity": "publication", "iuid": "db66a5d743f54eb4b1dd5e5a1d97a38a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db66a5d743f54eb4b1dd5e5a1d97a38a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db66a5d743f54eb4b1dd5e5a1d97a38a"}}, "title": "Antibody responses after a single dose of ChAdOx1 nCoV-19 vaccine in healthcare workers previously infected with SARS-CoV-2.", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f28f2f6ac9648629c2d2de92fe7bb59.json"}}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/305bca9e5c6c423898c272bf06ce2f2a.json"}}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Salomonsson", "given": "Ann-Christin", "initials": "AC"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1345-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a53a433db6f04a458e3d420f0c9995c5.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": "70", "issue": null, "pages": "103523"}, "abstract": "Recent reports demonstrate robust serological responses to a single dose of messenger RNA (mRNA) vaccines in individuals previously infected with SARS-CoV-2. Data on immune responses following a single-dose adenovirus-vectored vaccine expressing the SARS-CoV-2 spike protein (ChAdOx1 nCoV-19) in individuals with previous SARS-CoV-2 infection are however limited, and current guidelines recommend a two-dose regimen regardless of preexisting immunity.\n\nWe compared RBD-specific IgG and RBD-ACE2 blocking antibodies against SARS-CoV-2 wild type and variants of concern following two doses of the mRNA vaccine BNT162b2 in SARS-CoV-2 na\u00efve healthcare workers (n=65) and a single dose of the adenovector vaccine ChAdOx1 nCoV-19 in 82 healthcare workers more than (n=45) and less than (n=37) 11 months post mild SARS-CoV-2 infection at time of vaccination.\n\nThe post-vaccine levels of RBD-specific IgG and neutralizing antibodies against the SARS-CoV-2 wild type and variants of concern including Delta lineage 1.617.2 were similar or higher in participants receiving a single dose of ChAdOx1 nCoV-19 vaccine post SARS-CoV-2 infection (both more than and less than 11 months post infection) compared to SARS-CoV-2 na\u00efve participants who received two doses of BNT162b2 vaccine.\n\nOur data support that a single dose ChAdOx1 nCoV-19 vaccine that is administered up to at least 11 months post SARS-CoV-2 infection serves as an effective immune booster. This provides a possible rationale for a single-dose vaccine regimen.\n\nA full list of funding bodies that contributed to this study can be found in the Acknowledgements section.", "doi": "10.1016/j.ebiom.2021.103523", "pmid": "34391088", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Drug discovery and repurposing of drugs": null, "Research Area: Host cell systems biology and targets": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8357428"}, {"db": "pii", "key": "S2352-3964(21)00316-9"}], "notes": [], "created": "2021-05-17T19:14:38.806Z", "modified": "2023-06-19T14:33:13.824Z"}, {"entity": "publication", "iuid": "88644ac51d8c41fcbf8cf8396c907d1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/88644ac51d8c41fcbf8cf8396c907d1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/88644ac51d8c41fcbf8cf8396c907d1d"}}, "title": "A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic.", "authors": [{"family": "Wang", "given": "Ke", "initials": "K", "orcid": "0000-0002-5776-0815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92a94307dd704b3086b3bc04ccd5dbfc.json"}}, {"family": "Goldenberg", "given": "Amit", "initials": "A"}, {"family": "Dorison", "given": "Charles A", "initials": "CA", "orcid": "0000-0002-7072-2530", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/333f1c9b074c4d38894624278ae79751.json"}}, {"family": "Miller", "given": "Jeremy K", "initials": "JK", "orcid": "0000-0003-4409-7660", "researcher": {"href": 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"https://publications-covid19.scilifelab.se/researcher/d67c255cec3a47b79ddaaf09b6c59cee.json"}}, {"family": "Ebersole", "given": "Charles R", "initials": "CR"}, {"family": "Chartier", "given": "Christopher R", "initials": "CR", "orcid": "0000-0002-4568-4827", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d62a113c9b8447585c9146ebe085e33.json"}}, {"family": "Mallik", "given": "Peter R", "initials": "PR"}, {"family": "Urry", "given": "Heather L", "initials": "HL", "orcid": "0000-0003-4915-1785", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1ef8e659f174f8fa429656c23a05452.json"}}, {"family": "Buchanan", "given": "Erin M", "initials": "EM", "orcid": "0000-0002-9689-4189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5878425d18e4c0cb1fa64b5a63df968.json"}}, {"family": "Coles", "given": "Nicholas A", "initials": "NA", "orcid": "0000-0001-8583-5610", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a0194b331e640dc8548c14eb7e3b2fd.json"}}, {"family": "Primbs", "given": "Maximilian A", "initials": "MA", "orcid": "0000-0002-3398-5569", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96936f42ec994e358255f23d7f969a97.json"}}, {"family": "Basnight-Brown", "given": "Dana M", "initials": "DM", "orcid": "0000-0002-7200-6976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ac1d426131d40eeb088a3ad71fbeb4e.json"}}, {"family": "IJzerman", "given": "Hans", "initials": "H", "orcid": "0000-0002-0990-2276", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0bb878701ae942e19cbb54fa33787a5a.json"}}, {"family": "Forscher", "given": "Patrick S", "initials": "PS", "orcid": "0000-0002-7763-3565", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d5f78c637ff45e6899240ac263367c3.json"}}, {"family": "Moshontz", "given": "Hannah", "initials": "H", "orcid": "0000-0003-4345-3715", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92ab3cbbe34b43abb40476227a7ee357.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Nat Hum Behav", "issn": "2397-3374", "volume": "5", "issue": "8", "pages": "1089-1110", "issn-l": "2397-3374"}, "abstract": "The COVID-19 pandemic has increased negative emotions and decreased positive emotions globally. Left unchecked, these emotional changes might have a wide array of adverse impacts. To reduce negative emotions and increase positive emotions, we tested the effectiveness of reappraisal, an emotion-regulation strategy that modifies how one thinks about a situation. Participants from 87 countries and regions (n = 21,644) were randomly assigned to one of two brief reappraisal interventions (reconstrual or repurposing) or one of two control conditions (active or passive). Results revealed that both reappraisal interventions (vesus both control conditions) consistently reduced negative emotions and increased positive emotions across different measures. Reconstrual and repurposing interventions had similar effects. Importantly, planned exploratory analyses indicated that reappraisal interventions did not reduce intentions to practice preventive health behaviours. The findings demonstrate the viability of creating scalable, low-cost interventions for use around the world. PROTOCOL REGISTRATION: The stage 1 protocol for this Registered Report was accepted in principle on 12 May 2020. The protocol, as accepted by the journal, can be found at https://doi.org/10.6084/m9.figshare.c.4878591.v1.", "doi": "10.1038/s41562-021-01173-x", "pmid": "34341554", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41562-021-01173-x"}, {"db": "URL", "key": "https://osf.io/jeu73/.", "description": "Raw data, processed data and code"}], "notes": [], "created": "2021-08-04T10:08:50.740Z", "modified": "2021-11-18T13:04:43.407Z"}, {"entity": "publication", "iuid": "2636d27430424f9ba9bbc3dcae9d5353", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2636d27430424f9ba9bbc3dcae9d5353.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2636d27430424f9ba9bbc3dcae9d5353"}}, "title": "A health systems resilience research agenda: moving from concept to practice.", "authors": [{"family": "Saulnier", "given": "Dell D", "initials": "DD", "orcid": "0000-0001-7761-0737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d3fc961101845b1ae844339af7495e4.json"}}, {"family": "Blanchet", "given": "Karl", "initials": "K", "orcid": "0000-0003-0498-8020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aad004843f3f44c8b011feedf86831e1.json"}}, {"family": "Canila", "given": "Carmelita", "initials": "C"}, {"family": "Cobos Mu\u00f1oz", "given": "Daniel", "initials": "D"}, {"family": "Dal Zennaro", "given": "Livia", "initials": "L"}, {"family": "de Savigny", "given": "Don", "initials": "D"}, {"family": "Durski", "given": "Kara N", "initials": "KN", "orcid": "0000-0003-1456-626X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c3c8647d0fb46f3bc270457481eccdb.json"}}, {"family": "Garcia", "given": "Fernando", "initials": "F"}, {"family": "Grimm", "given": "Pauline Yongeun", "initials": "PY"}, {"family": "Kwamie", "given": "Aku", "initials": "A"}, {"family": "Maceira", "given": "Daniel", "initials": "D"}, {"family": "Marten", "given": "Robert", "initials": "R", "orcid": "0000-0002-2416-2309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5304e89b214846d0a6f2097df8eb1439.json"}}, {"family": "Peytremann-Bridevaux", "given": "Isabelle", "initials": "I"}, {"family": "Poroes", "given": "Camille", "initials": "C"}, {"family": "Ridde", "given": "Valery", "initials": "V", "orcid": "0000-0001-9299-8266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e62a45cb15a4d66966e72c363547b2d.json"}}, {"family": "Seematter", "given": "Laurence", "initials": "L"}, {"family": "Stern", "given": "Barbara", "initials": "B"}, {"family": "Suarez", "given": "Patricia", "initials": "P"}, {"family": "Teddy", "given": "Gina", "initials": "G"}, {"family": "Wernli", "given": "Didier", "initials": "D", "orcid": "0000-0002-1751-1961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d61d17a45a24592aa9bf5ebea861503.json"}}, {"family": "Wyss", "given": "Kaspar", "initials": "K"}, {"family": "Tediosi", "given": "Fabrizio", "initials": "F", "orcid": "0000-0001-8671-9400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9884188f9c04312b05212ade939818d.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "8", "issn-l": "2059-7908"}, "abstract": "Health system resilience, known as the ability for health systems to absorb, adapt or transform to maintain essential functions when stressed or shocked, has quickly gained popularity following shocks like COVID-19. The concept is relatively new in health policy and systems research and the existing research remains mostly theoretical. Research to date has viewed resilience as an outcome that can be measured through performance outcomes, as an ability of complex adaptive systems that is derived from dynamic behaviour and interactions, or as both. However, there is little congruence on the theory and the existing frameworks have not been widely used, which as diluted the research applications for health system resilience. A global group of health system researchers were convened in March 2021 to discuss and identify priorities for health system resilience research and implementation based on lessons from COVID-19 and other health emergencies. Five research priority areas were identified: (1) measuring and managing systems dynamic performance, (2) the linkages between societal resilience and health system resilience, (3) the effect of governance on the capacity for resilience, (4) creating legitimacy and (5) the influence of the private sector on health system resilience. A key to filling these research gaps will be longitudinal and comparative case studies that use cocreation and coproduction approaches that go beyond researchers to include policy-makers, practitioners and the public.", "doi": "10.1136/bmjgh-2021-006779", "pmid": "34353820", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-006779"}], "notes": [], "created": "2021-08-11T14:41:14.804Z", "modified": "2021-08-11T14:41:14.962Z"}, {"entity": "publication", "iuid": "21a1ff9833a248a497680dccbef0cb6b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/21a1ff9833a248a497680dccbef0cb6b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/21a1ff9833a248a497680dccbef0cb6b"}}, "title": "Investigating tinnitus subgroups based on hearing-related difficulties.", "authors": [{"family": "Beukes", "given": "Eldr\u00e9 W", "initials": "EW", "orcid": "0000-0002-9434-9160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b5ab9ec02014cd9bd58a095f8175dd2.json"}}, {"family": "Baguley", "given": "David M", "initials": "DM"}, {"family": "Manchaiah", "given": "Vinaya", "initials": "V"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Allen", "given": "Peter M", "initials": "PM"}, {"family": "Kaldo", "given": "Viktor", "initials": "V"}, {"family": "Jacquemin", "given": "Laure", "initials": "L"}, {"family": "Lourenco", "given": "Matheus P C G", "initials": "MPCG"}, {"family": "Onozuka", "given": "Joy", "initials": "J"}, {"family": "Stockdale", "given": "David", "initials": "D"}, {"family": "Maidment", "given": "David W", "initials": "DW"}], "type": "journal article", "published": "2021-07-31", "journal": {"title": "Int J Clin Pract", "issn": "1742-1241", "pages": "e14684", "issn-l": null}, "abstract": "Meaningfully grouping individuals with tinnitus who share the common characteristics (i.e., subgrouping, phenotyping) may help tailor interventions to certain tinnitus subgroups and hence reduce outcome variability. The purpose of this study was to test if the presence of tinnitus subgroups are discernible based on hearing-related comorbidities, and to identify predictors of tinnitus severity for each subgroup identified.\n\nAn exploratory cross-sectional study was used. The study was nested within an online survey distributed worldwide to investigate tinnitus experiences during the COVID-19 pandemic. The main outcome measure was the tinnitus Handicap Inventory- Screening Version RESULTS: From the 3400 respondents, 2,980 were eligible adults with tinnitus with an average age of 58 years (SD= 14.7) with 50% (n= 1,457) being female. A three-cluster solution identified distinct subgroups, namely, those with tinnitus but no hearing loss (n = 1,306; 44%), those presenting with tinnitus and hyperacusis and/or misophonia (n = 795; 27%), and those with tinnitus and hearing loss (n = 879; 29%). Those with tinnitus and hyperacusis reported the highest tinnitus severity (M= 20.3; SD= 10.5) and those with tinnitus and no hearing loss had the lowest tinnitus severity (M= 15.7; SD= 10.4). Younger age and the presence of mental health problems predicted greater tinnitus severity for all groups (\u03b2\u2264 -.1, p\u2264 .016).\n\nFurther exploration of these potential subtypes are needed in both further research and clinical practice by initially triaging tinnitus patients prior to their clinical appointments based on the presence of hearing-related comorbidities. Unique management pathways and interventions could be tailored for each tinnitus subgroup.", "doi": "10.1111/ijcp.14684", "pmid": "34331723", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-04T17:02:52.619Z", "modified": "2021-08-04T17:02:52.661Z"}, {"entity": "publication", "iuid": "1dcc9c1c68f9403da3ab22f2eb3e8cb3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1dcc9c1c68f9403da3ab22f2eb3e8cb3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1dcc9c1c68f9403da3ab22f2eb3e8cb3"}}, "title": "High expression of neutrophil and monocyte CD64 with simultaneous lack of upregulation of adhesion receptors CD11b, CD162, CD15, CD65 on neutrophils in severe COVID-19.", "authors": [{"family": "Karawajczyk", "given": "Malgorzata", "initials": "M", "orcid": "0000-0001-8192-0076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e42747d6ce4241f9aaa79c597475dc62.json"}}, {"family": "Douhan H\u00e5kansson", "given": "Lena", "initials": "L"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Pauksens", "given": "Karlis", "initials": "K"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Larsson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-07-31", "journal": {"title": "Ther Adv Infect Dis", "issn": "2049-9361", "issn-l": null, "volume": "8", "issue": null, "pages": "20499361211034065"}, "abstract": "The pronounced neutrophilia observed in patients with coronavirus disease 2019 (COVID-19) infections suggests a role for these leukocytes in the pathology of the disease. Monocyte and neutrophil expression of CD64 and CD11b have been reported as early biomarkers to detect infections. The aim of this study was to study the expression of receptors for IgG (CD64) and adhesion molecules (CD11b, CD15s, CD65, CD162, CD66b) on neutrophils and monocytes in patients with severe COVID-19 after admission to an intensive care unit (ICU).\n\nThe expression of receptors was analyzed using flow cytometry. EDTA blood from 23 patients with confirmed COVID-19 infection was sampled within 48 h of admission to the ICU. Leukocytes were labeled with antibodies to CD11b, CD15s, CD65s, CD162, CD64, and CD66b. Expression of receptors was reported as mean fluorescence intensity (MFI) or the percentage of cells expressing receptors.\n\nResults are presented as comparison of COVID-19 patients with the healthy group and the receptor expression as MFI. Neutrophil receptors CD64 (2.5 versus 0.5) and CD66b (44.5 versus 34) were increased and CD15 decreased (21.6 versus 28.3) when CD65 (6.6 versus 4.4), CD162 (21.3 versus 21.1) and CD11b (10.5 versus 12) were in the same range. Monocytes receptors CD64 (30.5 versus 16.6), CD11b (18.7 versus 9.8), and CD162 (38.6 versus 36.5) were increased and CD15 decreased (10.3 versus 17.9); CD65 were in the same range (2.3 versus 1.96).\n\nMonocytes and neutrophils are activated during severe COVID-19 infection as shown by strong upregulation of CD64. High monocyte and neutrophil CD64 can be an indicator of a severe form of COVID19. The adhesion molecules (CD11b, CD162, CD65, and CD15) are not upregulated on otherwise activated neutrophils, which might lead to relative impairment of tissue migration. Low adhesion profile of neutrophils suggests immune dysfunction of neutrophils. Monocytes maintain upregulation of some adhesion molecules (CD11b, CD162) suggesting the persistence of an increased ability to migrate into tissues, even during a severe stage of COVID-19. Future research should focus on CD64 and CD11b kinetics in the context of prognosis.", "doi": "10.1177/20499361211034065", "pmid": "34377464", "labels": {"Funder: VR": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pmc", "key": "PMC8326822"}, {"db": "pii", "key": "10.1177_20499361211034065"}], "notes": [], "created": "2021-08-12T17:04:26.909Z", "modified": "2023-06-19T14:59:17.671Z"}, {"entity": "publication", "iuid": "c588fa750a8444f6858a06bdaafe89cd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c588fa750a8444f6858a06bdaafe89cd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c588fa750a8444f6858a06bdaafe89cd"}}, "title": "Anti-Viral and Immunomodulatory Properties of Propolis: Chemical Diversity, Pharmacological Properties, Preclinical and Clinical Applications, and In Silico Potential against SARS-CoV-2.", "authors": [{"family": "Yosri", "given": "Nermeen", "initials": "N", "orcid": "0000-0002-5043-9690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4179b7f496234c44bfb86f42d793209f.json"}}, {"family": "Abd El-Wahed", "given": "Aida A", "initials": "AA", "orcid": "0000-0002-2200-3507", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c6fbed70bba4ea79707d30822d774bd.json"}}, {"family": "Ghonaim", "given": "Reem", "initials": "R"}, {"family": "Khattab", "given": "Omar M", "initials": "OM"}, {"family": "Sabry", "given": "Aya", "initials": "A"}, {"family": "Ibrahim", "given": "Mahmoud A A", "initials": "MAA", "orcid": "0000-0003-4819-2040", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/552195f5616e456b82fd45359b56f9c7.json"}}, {"family": "Moustafa", "given": "Mahmoud F", "initials": "MF"}, {"family": "Guo", "given": "Zhiming", "initials": "Z", "orcid": "0000-0001-6416-7457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3be657eca2a84ef48613cd71b9a43222.json"}}, {"family": "Zou", "given": "Xiaobo", "initials": "X"}, {"family": "Algethami", "given": "Ahmed F M", "initials": "AFM"}, {"family": "Masry", "given": "Saad H D", "initials": "SHD"}, {"family": "AlAjmi", "given": "Mohamed F", "initials": "MF"}, {"family": "Afifi", "given": "Hanan S", "initials": "HS"}, {"family": "Khalifa", "given": "Shaden A M", "initials": "SAM"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}], "type": "journal article", "published": "2021-07-31", "journal": {"title": "Foods", "issn": "2304-8158", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "Propolis, a resin produced by honeybees, has long been used as a dietary supplement and folk remedy, and more recent preclinical investigations have demonstrated a large spectrum of potential therapeutic bioactivities, including antioxidant, antibacterial, anti-inflammatory, neuroprotective, immunomodulatory, anticancer, and antiviral properties. As an antiviral agent, propolis and various constituents have shown promising preclinical efficacy against adenoviruses, influenza viruses, respiratory tract viruses, herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), human immunodeficiency virus (HIV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Over 300 chemical components have been identified in propolis, including terpenes, flavonoids, and phenolic acids, with the specific constituent profile varying widely according to geographic origin and regional flora. Propolis and its constituents have demonstrated potential efficacy against SARS-CoV-2 by modulating multiple pathogenic and antiviral pathways. Molecular docking studies have demonstrated high binding affinities of propolis derivatives to multiple SARS-CoV-2 proteins, including 3C-like protease (3CLpro), papain-like protease (PLpro), RNA-dependent RNA polymerase (RdRp), the receptor-binding domain (RBD) of the spike protein (S-protein), and helicase (NSP13), as well as to the viral target angiotensin-converting enzyme 2 (ACE2). Among these compounds, retusapurpurin A has shown high affinity to 3CLpro (\u0394G = -9.4 kcal/mol), RdRp (-7.5), RBD (-7.2), NSP13 (-9.4), and ACE2 (-10.4) and potent inhibition of viral entry by forming hydrogen bonds with amino acid residues within viral and human target proteins. In addition, propolis-derived baccharin demonstrated even higher binding affinity towards PLpro (-8.2 kcal/mol). Measures of drug-likeness parameters, including metabolism, distribution, absorption, excretion, and toxicity (ADMET) characteristics, also support the potential of propolis as an effective agent to combat COVID-19.", "doi": "10.3390/foods10081776", "pmid": "34441553", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "foods10081776"}, {"db": "pmc", "key": "PMC8391193"}], "notes": [], "created": "2021-09-01T07:15:52.044Z", "modified": "2021-09-01T07:15:52.145Z"}, {"entity": "publication", "iuid": "199aec09cf01468a9111c3c31b8302eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/199aec09cf01468a9111c3c31b8302eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/199aec09cf01468a9111c3c31b8302eb"}}, "title": "Swedish Covid-19 Investigation for Future Insights - A Population Epidemiology Approach Using Register Linkage (SCIFI-PEARL).", "authors": [{"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Franz\u00e9n", "given": "Stefan", "initials": "S"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Vanfleteren", "given": "Lowie", "initials": "L", "orcid": "0000-0002-4387-4096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bb5d1f761ef48c4837ed4f984717f0e.json"}}, {"family": "Hammar", "given": "Niklas", "initials": "N"}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2c4588f000c470abf08f2e40852b6d1.json"}}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Bj\u00f6rck", "given": "Staffan", "initials": "S"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}], "type": "journal article", "published": "2021-07-30", "journal": {"title": "CLEP", "issn": "1179-1349", "issn-l": null, "volume": "13", "issue": null, "pages": "649-659"}, "abstract": "In response to the Covid-19 pandemic, we designed and initiated a nationwide linked multi-register, regularly updated, observational study for timely response to urgent scientific questions.\r\n\r\nTo describe the SCIFI-PEARL (Swedish Covid-19 Investigation for Future Insights - a Population Epidemiology Approach using Register Linkage) linked database encompassing essentially all known diagnosed Swedish Covid-19 patients plus a large general population comparison cohort and outline its utility in the current and future phases of the pandemic.\r\n\r\nIndividuals with Covid-19 from the entire country are identified on a regularly updated basis, from different sources: all individuals from SmiNet, the national database of notifiable diseases, with positive SARS-CoV-2 polymerase chain reaction (PCR) test results; patients identified in the healthcare system by condition (ICD-10) or procedure codes in the National Patient Register or Cause-of-Death Register; patients identified through several disease-specific national quality registers (NQRs); and in two regions additionally patients identified in primary care. A comparison population was obtained by stratified random sampling from Swedish national population registers. Data from all these registers plus the National Prescribed Drug Register, the Cancer Register, national sociodemographic registers, some additional NQRs, the National Vaccination Register, and further data sources, are then linked to all study subjects (Covid-19 cases and population cohort). New cases in the study population and all data for all subjects are updated every few months, as required.\r\n\r\nThe SCIFI-PEARL study cohort captures Swedish residents with Covid-19 on an ongoing basis, includes a representative general population comparison cohort, and links to a broad range of national and regional healthcare data for a comprehensive longitudinal view of the Covid-19 pandemic. By combining high-quality national registers with short time delay and continuous repeated linkage and updating, the project brings timely and internationally relevant data for epidemiological research on SARS-CoV-2. Our efforts provide an example and important learnings for similar efforts internationally in the future.", "doi": "10.2147/CLEP.S312742", "pmid": "34354377", "labels": {"Research Area: Vaccine": null, "Category: Public Health": null, "Type: Journal article": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "312742"}, {"db": "pmc", "key": "PMC8331198"}], "notes": [], "created": "2021-08-12T12:22:04.801Z", "modified": "2021-12-06T12:29:00.905Z"}, {"entity": "publication", "iuid": "89bcd628edf945e68aed0254ce19aa95", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/89bcd628edf945e68aed0254ce19aa95.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/89bcd628edf945e68aed0254ce19aa95"}}, "title": "Impact of the COVID-19 pandemic on nuclear medicine departments in Europe.", "authors": [{"family": "Moreira", "given": "Ana Paula", "initials": "AP", "orcid": "0000-0001-6873-6039", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5f3afab19af4ba3a538c1a387b69642.json"}}, {"family": "Jamar", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Ozcan", "given": "Zehra", "initials": "Z"}, {"family": "Piciu", "given": "Doina", "initials": "D"}, {"family": "Als", "given": "Claudine", "initials": "C"}, {"family": "Franceschi", "given": "Maja", "initials": "M"}, {"family": "Tr\u00e4g\u00e5rdh", "given": "Elin", "initials": "E"}, {"family": "Zagar", "given": "Ivana", "initials": "I"}, {"family": "Sowa-Staszczak", "given": "Anna", "initials": "A"}, {"family": "Cachin", "given": "Florent", "initials": "F"}, {"family": "Bennink", "given": "Roel", "initials": "R"}, {"family": "Forrer", "given": "Flavio", "initials": "F"}, {"family": "Adamsen", "given": "Tom Christian", "initials": "TC"}, {"family": "Fotopolous", "given": "Andreas", "initials": "A"}, {"family": "Kalnina", "given": "Marika", "initials": "M"}, {"family": "Jensen", "given": "Lars Thorbj\u00f8rn", "initials": "LT"}, {"family": "Mussalo", "given": "Hanna", "initials": "H"}, {"family": "Simanek", "given": "Milan", "initials": "M"}, {"family": "Garcia-Ca\u00f1amaque", "given": "Lina", "initials": "L"}, {"family": "Nazarenko", "given": "Sergei", "initials": "S"}, {"family": "Mihailovic", "given": "Jasna", "initials": "J"}, {"family": "Bar-Sever", "given": "Zvi", "initials": "Z"}, {"family": "O'Connell", "given": "Martin", "initials": "M"}, {"family": "Miladinova", "given": "Daniela", "initials": "D"}, {"family": "Graham", "given": "Richard", "initials": "R"}, {"family": "Giubbini", "given": "Raffaele", "initials": "R"}, {"family": "Kalisk\u00e1", "given": "Lucia", "initials": "L"}, {"family": "Rozi\u0107", "given": "Damir", "initials": "D"}, {"family": "Krause", "given": "Bernd J", "initials": "BJ"}, {"family": "Gallowitsch", "given": "Hans-J\u00fcrgen", "initials": "HJ"}, {"family": "Gy\u00f6rke", "given": "Tam\u00e1s", "initials": "T"}, {"family": "Sediene", "given": "Severina", "initials": "S"}, {"family": "Rumyantsev", "given": "Pavel", "initials": "P"}, {"family": "Wadsak", "given": "Wolfgang", "initials": "W"}, {"family": "Kunikowska", "given": "Jolanta", "initials": "J"}], "type": "editorial", "published": "2021-07-30", "journal": {"title": "Eur J Nucl Med Mol Imaging", "issn": "1619-7089", "issn-l": null}, "abstract": null, "doi": "10.1007/s00259-021-05484-z", "pmid": "34328532", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00259-021-05484-z"}, {"db": "pmc", "key": "PMC8322112"}], "notes": [], "created": "2021-08-04T17:03:29.051Z", "modified": "2021-08-04T17:03:29.091Z"}, {"entity": "publication", "iuid": "95872c856b0a43b89e3f3a8ebeb8a3f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95872c856b0a43b89e3f3a8ebeb8a3f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95872c856b0a43b89e3f3a8ebeb8a3f4"}}, "title": "Antimicrobial stewardship in the ICU in COVID times: the known unknowns.", "authors": [{"family": "Schouten", "given": "Jeroen", "initials": "J"}, {"family": "De Waele", "given": "Jan", "initials": "J"}, {"family": "Lanckohr", "given": "Christian", "initials": "C"}, {"family": "Koulenti", "given": "Despoina", "initials": "D"}, {"family": "Haddad", "given": "Nisrine", "initials": "N"}, {"family": "Rizk", "given": "Nesrine", "initials": "N"}, {"family": "Sj\u00f6vall", "given": "Fredrik", "initials": "F"}, {"family": "Kanj", "given": "Souha S", "initials": "SS"}], "type": "journal article", "published": "2021-07-30", "journal": {"title": "Int J Antimicrob Agents", "issn": "1872-7913", "issn-l": null, "volume": null, "issue": null, "pages": "106409"}, "abstract": "Since the start of the COVID-19 pandemic, there has been concern about the concomitant rise of antimicrobial resistance (AMR). While bacterial co-infections seem rare in COVID-19 patients admitted to hospital wards and ICUs, an increase in empirical antibiotic use has been described. In the ICU setting, where antibiotics are already abundantly -and often inappropriately- prescribed, the need for an ICU specific Antimicrobial Stewardship Program (ASP) is widely advocated. Apart from essentially warning against the use of antibacterial drugs for the treatment of a viral infection, other aspects of ICU antimicrobial stewardship need to be considered in view of the clinical course and characteristics of COVID-19. First, the distinction between infectious and non-infectious (inflammatory) causes of respiratory deterioration during ICU stay is difficult and the much-debated relevance of fungal and viral co-infections adds to the complexity of empirical antimicrobial prescribin. Biomarkers such as PCT for the decision to start antibacterial therapy for ICU nosocomial infections seem to be more promising in COVID-19 than in non-COVID-19 patients. In COVID-19 patients CMV reactivation is an important factor to consider when assessing patients infected with SARS-CoV-2 as it may have a role in modulating patient immune response. The diagnosis of COVID-19 associated Invasive Aspergillosis (CAPA) is challenging because of the lack of sensitivity and specificity of the available tests. Further, altered PK/PD properties need to be taken into account when prescribing antimicrobial therapy. Future research should now further explore the \"known unknowns\", ideally with robust prospective study designs.", "doi": "10.1016/j.ijantimicag.2021.106409", "pmid": "34339777", "labels": {"Type: Review": null, "Category: Public Health": null, "Category: Rehabilitation": null}, "xrefs": [{"db": "pii", "key": "S0924-8579(21)00181-3"}], "notes": [], "created": "2021-08-04T10:11:22.551Z", "modified": "2021-11-18T12:48:00.214Z"}, {"entity": "publication", "iuid": "448436ec26c24e71bc517a9bce6d8e45", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/448436ec26c24e71bc517a9bce6d8e45.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/448436ec26c24e71bc517a9bce6d8e45"}}, "title": "A look into the future of the COVID-19 pandemic in Europe: an expert consultation.", "authors": [{"family": "Iftekhar", "given": "Emil Nafis", "initials": "EN"}, {"family": "Priesemann", "given": "Viola", "initials": "V"}, {"family": "Balling", "given": "Rudi", "initials": "R"}, {"family": "Bauer", "given": "Simon", "initials": "S"}, {"family": "Beutels", "given": "Philippe", "initials": "P"}, {"family": "Calero Valdez", "given": "Andr\u00e9", "initials": "A"}, {"family": "Cuschieri", "given": "Sarah", "initials": "S"}, {"family": "Czypionka", "given": "Thomas", "initials": "T"}, {"family": "Dumpis", "given": "Uga", "initials": "U"}, {"family": "Glaab", "given": "Enrico", "initials": "E"}, {"family": "Grill", "given": "Eva", "initials": "E"}, {"family": "Hanson", "given": "Claudia", "initials": "C"}, {"family": "Hotulainen", "given": "Pirta", "initials": "P"}, {"family": "Klimek", "given": "Peter", "initials": "P"}, {"family": "Kretzschmar", "given": "Mirjam", "initials": "M"}, {"family": "Kr\u00fcger", "given": "Tyll", "initials": "T"}, {"family": "Krutzinna", "given": "Jenny", "initials": "J"}, {"family": "Low", "given": "Nicola", "initials": "N"}, {"family": "Machado", "given": "Helena", "initials": "H"}, {"family": "Martins", "given": "Carlos", "initials": "C"}, {"family": "McKee", "given": "Martin", "initials": "M"}, {"family": "Mohr", "given": "Sebastian Bernd", "initials": "SB"}, {"family": "Nassehi", "given": "Armin", "initials": "A"}, {"family": "Perc", "given": "Matja\u017e", "initials": "M"}, {"family": "Petelos", "given": "Elena", "initials": "E"}, {"family": "Pickersgill", "given": "Martyn", "initials": "M"}, {"family": "Prainsack", "given": "Barbara", "initials": "B"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}, {"family": "Schernhammer", "given": "Eva", "initials": "E"}, {"family": "Staines", "given": "Anthony", "initials": "A"}, {"family": "Szczurek", "given": "Ewa", "initials": "E"}, {"family": "Tsiodras", "given": "Sotirios", "initials": "S"}, {"family": "Van Gucht", "given": "Steven", "initials": "S"}, {"family": "Willeit", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2021-07-30", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "pages": "100185", "issn-l": null}, "abstract": "How will the coronavirus disease 2019 (COVID-19) pandemic develop in the coming months and years? Based on an expert survey, we examine key aspects that are likely to influence the COVID-19 pandemic in Europe. The challenges and developments will strongly depend on the progress of national and global vaccination programs, the emergence and spread of variants of concern (VOCs), and public responses to non-pharmaceutical interventions (NPIs). In the short term, many people remain unvaccinated, VOCs continue to emerge and spread, and mobility and population mixing are expected to increase. Therefore, lifting restrictions too much and too early risk another damaging wave. This challenge remains despite the reduced opportunities for transmission given vaccination progress and reduced indoor mixing in summer 2021. In autumn 2021, increased indoor activity might accelerate the spread again, whilst a necessary reintroduction of NPIs might be too slow. The incidence may strongly rise again, possibly filling intensive care units, if vaccination levels are not high enough. A moderate, adaptive level of NPIs will thus remain necessary. These epidemiological aspects combined with economic, social, and health-related consequences provide a more holistic perspective on the future of the COVID-19 pandemic.", "doi": "10.1016/j.lanepe.2021.100185", "pmid": "34345876", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00162-9"}, {"db": "pmc", "key": "PMC8321710"}], "notes": [], "created": "2021-08-06T09:46:00.472Z", "modified": "2021-08-06T09:46:00.483Z"}, {"entity": "publication", "iuid": "7864977a8d4f41e0adbbdf3e5152c4cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7864977a8d4f41e0adbbdf3e5152c4cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7864977a8d4f41e0adbbdf3e5152c4cf"}}, "title": "Understanding and Responding to the Impact of COVID-19 on Paediatric Gastroenterology Training & Practice of Young ESPGHAN Members.", "authors": [{"family": "Ni\u0163\u0103", "given": "Andreia F", "initials": "AF"}, {"family": "Tsita", "given": "Despina", "initials": "D"}, {"family": "Grima", "given": "Anne-Marie", "initials": "AM"}, {"family": "Cameron", "given": "Fiona", "initials": "F"}, {"family": "Rock", "given": "Nathalie M", "initials": "NM"}, {"family": "Tapsas", "given": "Dimitrios", "initials": "D"}], "type": "journal article", "published": "2021-07-29", "journal": {"title": "J Pediatr Gastroenterol Nutr", "issn": "1536-4801", "issn-l": null}, "abstract": "Limited data exist about the impact of the COVID-19 pandemic on the training and clinical practice of young doctors. The aim of this study was to evaluate the impact on paediatric gastroenterologists in training posts during the first wave of European COVID pandemic.\n\nAll Young ESPGHAN (YE) members received a multiple-choice questionnaire concerning the impact (if any) on their clinical practice, mental health, quality of care provided and fellowship/training experience. The survey was conducted between May 22nd, 2020 and June 10th, 2020.\n\nOf the 144 responders (40% of YE members), 85% (n = 123) reported an impact of COVID-19. 96% reported an impact on their clinical practice, including more virtual patient consultation (n = 91), underutilization of ambulatory care (n = 113) and reduced or lack of planned admissions (n = 75). Endoscopy restrictions to semi-urgent or emergency cases were reported in 82 and lack of medical equipment/drugs (n = 47) were also reported.Reported adverse mental health issues included poor concentration, increased stress levels, an impact on family life in 62% and a reduced quality of care in 45%; this was more often reported in doctors from Southern Europe (54%) than in those from other geographical areas.77% reported an impact on the content of their fellowship, including lack of participation in national/international meetings, withdrawn research time and limited mentoring.\n\nThe impact of the Covid-19 pandemic has been shown to affect the clinical practice, training and mental health of YE members. Adaptations of training programmes and targeted strategies to improve the clinical practice of young practitioners are needed and proposed in this manuscript.", "doi": "10.1097/MPG.0000000000003239", "pmid": "34269327", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00005176-900000000-95598"}], "notes": [], "created": "2021-08-06T07:16:08.125Z", "modified": "2021-08-06T07:16:08.151Z"}, {"entity": "publication", "iuid": "873495dc287a4506b7d1aad39e7087eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/873495dc287a4506b7d1aad39e7087eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/873495dc287a4506b7d1aad39e7087eb"}}, "title": "Topological network based drug repurposing for coronavirus 2019.", "authors": [{"family": "Habibi", "given": "Mahnaz", "initials": "M", "orcid": "0000-0002-8969-2706", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d44ce728e5d5412e8720941daae54a51.json"}}, {"family": "Taheri", "given": "Golnaz", "initials": "G"}], "type": "journal article", "published": "2021-07-29", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "7", "pages": "e0255270", "issn-l": "1932-6203"}, "abstract": "The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has become the current health concern and threat to the entire world. Thus, the world needs the fast recognition of appropriate drugs to restrict the spread of this disease. The global effort started to identify the best drug compounds to treat COVID-19, but going through a series of clinical trials and our lack of information about the details of the virus's performance has slowed down the time to reach this goal. In this work, we try to select the subset of human proteins as candidate sets that can bind to approved drugs. Our method is based on the information on human-virus protein interaction and their effect on the biological processes of the host cells. We also define some informative topological and statistical features for proteins in the protein-protein interaction network. We evaluate our selected sets with two groups of drugs. The first group contains the experimental unapproved treatments for COVID-19, and we show that from 17 drugs in this group, 15 drugs are approved by our selected sets. The second group contains the external clinical trials for COVID-19, and we show that 85% of drugs in this group, target at least one protein of our selected sets. We also study COVID-19 associated protein sets and identify proteins that are essential to disease pathology. For this analysis, we use DAVID tools to show and compare disease-associated genes that are contributed between the COVID-19 comorbidities. Our results for shared genes show significant enrichment for cardiovascular-related, hypertension, diabetes type 2, kidney-related and lung-related diseases. In the last part of this work, we recommend 56 potential effective drugs for further research and investigation for COVID-19 treatment. Materials and implementations are available at: https://github.com/MahnazHabibi/Drug-repurposing.", "doi": "10.1371/journal.pone.0255270", "pmid": "34324563", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-13445"}, {"db": "pmc", "key": "PMC8320924"}], "notes": [], "created": "2021-08-04T17:08:35.085Z", "modified": "2021-08-04T17:08:51.831Z"}, {"entity": "publication", "iuid": "d31bb5c7c6454cc9b62516cf7715a905", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d31bb5c7c6454cc9b62516cf7715a905.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d31bb5c7c6454cc9b62516cf7715a905"}}, "title": "JAK Inhibitors \u2014 More Than Just Glucocorticoids", "authors": [{"family": "Stebbing", "given": "Justin", "initials": "J", "orcid": "0000-0002-1117-6947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/556a75be47ab4c48922a55999648d4e3.json"}}, {"family": "Lauschke", "given": "Volker M", "initials": "VM"}], "type": "journal-article", "published": "2021-07-29", "journal": {"title": "N Engl J Med", "issn": "1533-4406", "volume": "385", "issue": "5", "pages": "463-465", "issn-l": null}, "abstract": null, "doi": "10.1056/nejme2108667", "pmid": null, "labels": {"Category: Drug Discovery": null, "Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-08-24T12:51:20.585Z", "modified": "2023-12-08T06:16:37.036Z"}, {"entity": "publication", "iuid": "771c423765b6417f97e55e79bf243e7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/771c423765b6417f97e55e79bf243e7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/771c423765b6417f97e55e79bf243e7e"}}, "title": "Impact of SARS-CoV-2 on training and mental well-being of surgical gynecological oncology trainees.", "authors": [{"family": "Gaba", "given": "Faiza", "initials": "F", "orcid": "0000-0003-4081-6883", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b6c7f32259c64092ba285fa71706aab6.json"}}, {"family": "Blyuss", "given": "Oleg", "initials": "O"}, {"family": "Rodriguez", "given": "Isabel", "initials": "I"}, {"family": "Dilley", "given": "James", "initials": "J"}, {"family": "Wan", "given": "Yee-Loi Louise", "initials": "YL"}, {"family": "Saiz", "given": "Allison", "initials": "A"}, {"family": "Razumova", "given": "Zoia", "initials": "Z", "orcid": "0000-0001-6598-0896", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f9dd79d57f44a0ab455974d84356528.json"}}, {"family": "Zalewski", "given": "Kamil", "initials": "K"}, {"family": "Nikolova", "given": "Tanja", "initials": "T"}, {"family": "Selcuk", "given": "Ilker", "initials": "I"}, {"family": "Bizzarri", "given": "Nicol\u00f2", "initials": "N", "orcid": "0000-0002-1727-904X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e74a49b3221461d87f46384492b5b7f.json"}}, {"family": "Theofanakis", "given": "Charalampos", "initials": "C"}, {"family": "Lanner", "given": "Maximilian", "initials": "M"}, {"family": "Pletnev", "given": "Andrei", "initials": "A"}, {"family": "Gurumurthy", "given": "Mahalakshmi", "initials": "M"}, {"family": "Manchanda", "given": "Ranjit", "initials": "R", "orcid": "0000-0003-3381-5057", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91c3585da7d84dc2b7a0788dbfdc78e2.json"}}], "type": "journal article", "published": "2021-07-29", "journal": {"title": "Int J Gynecol Cancer", "issn": "1525-1438", "issn-l": null}, "abstract": "The SARS-CoV-2 global pandemic has caused a crisis disrupting health systems worldwide. While efforts are being made to determine the extent of the disruption, the impact on gynecological oncology trainees/training has not been explored. We conducted an international survey of the impact of SARS-CoV-2 on clinical practice, medical education, and mental well-being of surgical gynecological oncology trainees.\n\nIn our cross-sectional study, a customized web-based survey was circulated to surgical gynecological oncology trainees from national/international organizations from May to November 2020. Validated questionnaires assessed mental well-being. The Wilcoxon rank-sum test and Fisher's exact test were used to analyse differences in means and proportions. Multiple linear regression was used to evaluate the effect of variables on psychological/mental well-being outcomes. Outcomes included clinical practice, medical education, anxiety and depression, distress, and mental well-being.\n\nA total of 127 trainees from 34 countries responded. Of these, 52% (66/127) were from countries with national training programs (UK/USA/Netherlands/Canada/Australia) and 48% (61/127) from countries with no national training programs. Altogether, 28% (35/125) had suspected/confirmed COVID-19, 28% (35/125) experienced a fall in household income, 20% (18/90) were self-isolated from households, 45% (57/126) had to re-use personal protective equipment, and 22% (28/126) purchased their own. In total, 32.3% (41/127) of trainees (16.6% (11/66) from countries with a national training program vs 49.1% (30/61) from countries with no national training program, p=0.02) perceived they would require additional time to complete their training fellowship. The additional training time anticipated did not differ between trainees from countries with or without national training programs (p=0.11) or trainees at the beginning or end of their fellowship (p=0.12). Surgical exposure was reduced for 50% of trainees. Departmental teaching continued throughout the pandemic for 69% (87/126) of trainees, although at reduced frequency for 16.1% (14/87), and virtually for 88.5% (77/87). Trainees reporting adequate pastoral support (defined as allocation of a dedicated mentor/access to occupational health support services) had better mental well-being with lower levels of anxiety/depression (p=0.02) and distress (p<0.001). Trainees from countries with a national training program experienced higher levels of distress (p=0.01). Mean (SD) pre-pandemic mental well-being scores were significantly higher than post-pandemic scores (8.3 (1.6) vs 7 (1.8); p<0.01).\n\nSARS-CoV-2 has negatively impacted the surgical training, household income, and psychological/mental well-being of surgical gynecological oncology trainees. The overall clinical impact was worse for trainees in countries with no national training program than for those in countries with a national training program, although national training program trainees reported greater distress. COVID-19 sickness increased anxiety/depression. The recovery phase must focus on improving mental well-being and addressing lost training opportunities.", "doi": "10.1136/ijgc-2021-002803", "pmid": "34326158", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijgc-2021-002803"}], "notes": [], "created": "2021-08-04T17:05:43.480Z", "modified": "2021-08-04T17:05:43.612Z"}, {"entity": "publication", "iuid": "fa473254c88e438882b511fa003724f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa473254c88e438882b511fa003724f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa473254c88e438882b511fa003724f0"}}, "title": "Comparing the First and Second Wave of COVID-19 in Kidney Transplant Recipients: An East-European Perspective.", "authors": [{"family": "Elec", "given": "Florin Ioan", "initials": "FI"}, {"family": "Bolboac\u0103", "given": "Sorana D", "initials": "SD"}, {"family": "Muntean", "given": "Adriana", "initials": "A"}, {"family": "Elec", "given": "Alina Daciana", "initials": "AD"}, {"family": "Cismaru", "given": "Cristina", "initials": "C"}, {"family": "Lup\u015fe", "given": "Mihaela", "initials": "M"}, {"family": "Oltean", "given": "Mihai", "initials": "M"}], "type": "journal article", "published": "2021-07-29", "journal": {"title": "Eur Surg Res", "issn": "1421-9921", "pages": "1-8", "issn-l": null}, "abstract": "The present study examined whether patient characteristics, management, and outcome of kidney transplant recipients (KTx) with COVID-19 changed in the second versus the first pandemic wave.\n\nWe reviewed all available data (demographics, medical history, comorbidities, therapeutic interventions, and outcome) on our KTx with COVID-19 during the first wave (March-September 2020, n = 33) and the second wave (October 2020-February 2021, n = 149) of the COVID-19 pandemic.\n\nOne hundred eighty-two out of our 1,503 KTx in active follow-up got COVID-19 during 12-month period, corresponding to a prevalence of 12.1%. No difference was found in age, gender distribution, comorbidities, body mass index, or baseline immunosuppression between the 2 COVID-19 waves. Bilateral COVID pneumonia was more frequent during the first wave. More KTx were managed as outpatients during the second wave (15 vs. 39%, p < 0.01). Calcineurin inhibitors were more sparingly reduced during the second wave, whereas antimetabolites were similarly reduced (91 vs. 86, p = ns). Admission to intensive care units was comparable between the first (27%) and second waves (23%). During the first wave, 8 out of 9 patients (89%) requiring intensive care died, whereas the mortality of the ICU patients in the second wave was 68% (23 deaths) (p = 0.2). The overall mortality was 24% during the first wave and 16% during the second wave (p = 0.21), while in-hospital mortality was identical between the CO-VID-19 waves (27%). Increasing age and poor allograft function were significant predictors of mortality.\n\nMost patient characteristics and outcome were comparable between the first 2 COVID-19 waves. More KTx were managed as outpatients without an overall negative impact on outcome.", "doi": "10.1159/000517559", "pmid": "34325432", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "000517559"}], "notes": [], "created": "2021-08-04T17:06:31.650Z", "modified": "2021-08-04T17:06:31.673Z"}, {"entity": "publication", "iuid": "b509475ceaa74df8b64815bc18f6d147", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b509475ceaa74df8b64815bc18f6d147.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b509475ceaa74df8b64815bc18f6d147"}}, "title": "Body mass index and Mini Nutritional Assessment-Short Form as predictors of in-geriatric hospital mortality in older adults with COVID-19.", "authors": [{"family": "Kananen", "given": "L", "initials": "L"}, {"family": "Eriksdotter", "given": "M", "initials": "M"}, {"family": "Bostr\u00f6m", "given": "A M", "initials": "AM"}, {"family": "Kivipelto", "given": "M", "initials": "M"}, {"family": "Annetorp", "given": "M", "initials": "M"}, {"family": "Metzner", "given": "C", "initials": "C"}, {"family": "B\u00e4ck Jerlardtz", "given": "V", "initials": "V"}, {"family": "Engstr\u00f6m", "given": "M", "initials": "M"}, {"family": "Johnson", "given": "P", "initials": "P"}, {"family": "Lundberg", "given": "L G", "initials": "LG"}, {"family": "\u00c5kesson", "given": "E", "initials": "E"}, {"family": "S\u00fchl \u00d6berg", "given": "C", "initials": "C"}, {"family": "H\u00e4gg", "given": "S", "initials": "S"}, {"family": "Religa", "given": "D", "initials": "D"}, {"family": "Jylh\u00e4v\u00e4", "given": "J", "initials": "J"}, {"family": "Cederholm", "given": "T", "initials": "T"}], "type": "journal article", "published": "2021-07-29", "journal": {"title": "Clin Nutr", "issn": "1532-1983", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Overweight and obesity have been consistently reported to carry an increased risk for poorer outcomes in coronavirus disease 2019 (COVID-19) in adults. Existing reports mainly focus on in-hospital and intensive care unit mortality in patient cohorts usually not representative of the population with the highest mortality, i.e. the very old and frail patients. Accordingly, little is known about the risk patterns related to body mass and nutrition in very old patients. Our aim was to assess the relationship between body mass index (BMI), nutritional status and in-geriatric hospital mortality among geriatric patients treated for COVID-19. As a reference, the analyses were performed also in patients treated for other diagnoses than COVID-19.\r\n\r\nWe analyzed up to 10,031 geriatric patients with a median age of 83 years of which 1409 (14%) were hospitalized for COVID-19 and 8622 (86%) for other diagnoses in seven geriatric hospitals in the Stockholm region, Sweden during March 2020-January 2021. Data were available in electronic hospital records. The associations between 1) BMI and 2) nutritional status, assessed using the Mini-Nutritional Assessment - Short Form (MNA-SF) scale, and short-term in-geriatric hospital mortality were analyzed using logistic regression.\r\n\r\nAfter adjusting for age, sex, comorbidity, polypharmacy, frailty and the wave of the pandemic (first vs. second), underweight defined as BMI<18.5 increased the risk of in-hospital mortality in COVID-19 patients (odds ratio [OR] = 2.30; confidence interval [CI] = 1.17-4.31). Overweight and obesity were not associated with in-hospital mortality. Malnutrition; i.e. MNA-SF 0-7 points, increased the risk of in-hospital mortality in patients treated for COVID-19 (OR = 2.03; CI = 1.16-3.68) and other causes (OR = 6.01; CI = 2.73-15.91).\r\n\r\nOur results indicate that obesity is not a risk factor for very old patients with COVID-19, but emphasize the role of underweight and malnutrition for in-hospital mortality in geriatric patients with COVID-19.", "doi": "10.1016/j.clnu.2021.07.025", "pmid": "34389208", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S0261-5614(21)00360-5"}], "notes": [], "created": "2021-08-16T09:26:21.338Z", "modified": "2021-08-25T14:35:56.646Z"}, {"entity": "publication", "iuid": "2bb6cb4f6e9b41fd8ef541d2b6f39a10", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2bb6cb4f6e9b41fd8ef541d2b6f39a10.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2bb6cb4f6e9b41fd8ef541d2b6f39a10"}}, "title": "Artificial Intelligence for Hospital Health Care: Application Cases and Answers to Challenges in European Hospitals.", "authors": [{"family": "Klumpp", "given": "Matthias", "initials": "M", "orcid": "0000-0002-7543-2751", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15df94e4fcab4a0db6c1d14583233d27.json"}}, {"family": "Hintze", "given": "Marcus", "initials": "M"}, {"family": "Immonen", "given": "Milla", "initials": "M"}, {"family": "R\u00f3denas-Rigla", "given": "Francisco", "initials": "F", "orcid": "0000-0003-3264-4735", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0038ea81bcec424e9af333117f5e677d.json"}}, {"family": "Pilati", "given": "Francesco", "initials": "F"}, {"family": "Aparicio-Mart\u00ednez", "given": "Fernando", "initials": "F"}, {"family": "\u00c7elebi", "given": "Dilay", "initials": "D", "orcid": "0000-0002-7103-3868", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/367982752bd54431aa5bdec8f6492ffe.json"}}, {"family": "Liebig", "given": "Thomas", "initials": "T", "orcid": "0000-0002-9841-1101", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14a857c22bbd49cea833f737f7635f42.json"}}, {"family": "Jirstrand", "given": "Mats", "initials": "M"}, {"family": "Urbann", "given": "Oliver", "initials": "O"}, {"family": "Hedman", "given": "Marja", "initials": "M", "orcid": "0000-0003-1318-8287", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5bf03be491024743b39ff1f0a8ba1fbe.json"}}, {"family": "Lipponen", "given": "Jukka A", "initials": "JA"}, {"family": "Bicciato", "given": "Silvio", "initials": "S", "orcid": "0000-0002-1944-7078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/284edb100a1f46bb83a0a404bbf7ba5b.json"}}, {"family": "Radan", "given": "Anda-Petronela", "initials": "AP", "orcid": "0000-0003-0113-2761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f75f9ec5a49f45189aca88d7f525d10a.json"}}, {"family": "Valdivieso", "given": "Bernardo", "initials": "B"}, {"family": "Thronicke", "given": "Wolfgang", "initials": "W"}, {"family": "Gunopulos", "given": "Dimitrios", "initials": "D"}, {"family": "Delgado-Gonzalo", "given": "Ricard", "initials": "R"}], "type": "journal article", "published": "2021-07-29", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "volume": "9", "issue": "8", "issn-l": null}, "abstract": "The development and implementation of artificial intelligence (AI) applications in health care contexts is a concurrent research and management question. Especially for hospitals, the expectations regarding improved efficiency and effectiveness by the introduction of novel AI applications are huge. However, experiences with real-life AI use cases are still scarce. As a first step towards structuring and comparing such experiences, this paper is presenting a comparative approach from nine European hospitals and eleven different use cases with possible application areas and benefits of hospital AI technologies. This is structured as a current review and opinion article from a diverse range of researchers and health care professionals. This contributes to important improvement options also for pandemic crises challenges, e.g., the current COVID-19 situation. The expected advantages as well as challenges regarding data protection, privacy, or human acceptance are reported. Altogether, the diversity of application cases is a core characteristic of AI applications in hospitals, and this requires a specific approach for successful implementation in the health care sector. This can include specialized solutions for hospitals regarding human-computer interaction, data management, and communication in AI implementation projects.", "doi": "10.3390/healthcare9080961", "pmid": "34442098", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "healthcare9080961"}, {"db": "pmc", "key": "PMC8393951"}], "notes": [], "created": "2021-09-01T07:15:14.462Z", "modified": "2021-09-01T07:15:14.633Z"}, {"entity": "publication", "iuid": "2ab52f4459a74cbd88570d67b152abcd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ab52f4459a74cbd88570d67b152abcd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ab52f4459a74cbd88570d67b152abcd"}}, "title": "Why women choose at-home abortion via teleconsultation in France: drivers of telemedicine abortion during and beyond the COVID-19 pandemic.", "authors": [{"family": "Atay", "given": "Hazal", "initials": "H", "orcid": "0000-0002-1634-6060", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/135c2f41c76e45a991573192b054aa03.json"}}, {"family": "Perivier", "given": "Helene", "initials": "H"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}, {"family": "Guilleminot", "given": "Jean", "initials": "J"}, {"family": "Hassoun", "given": "Danielle", "initials": "D"}, {"family": "Hottois", "given": "Judith", "initials": "J"}, {"family": "Gomperts", "given": "Rebecca", "initials": "R"}, {"family": "Levrier", "given": "Emmanuelle", "initials": "E"}], "type": "journal article", "published": "2021-07-28", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-2009", "issn-l": "2515-1991"}, "abstract": "In an attempt to understand the demand and main drivers of telemedicine abortion, we analysed the requests that Women on Web (WoW), an online telemedicine abortion service operating worldwide, received from France throughout 2020.\n\nWe conducted a parallel, convergent, mixed-methods study among 809 consultations received from France at WoW between 1 January and 31 December 2020. We performed a cross-sectional study of data obtained from the WoW consultation survey and a manifest content analysis of anonymised email correspondence of 140 women consulting with the WoW helpdesk from France.\n\nWe found that women encounter macro-level, individual-level and provider-level constraints while trying to access abortion in France. The preferences and needs over secrecy (n=356, 46.2%), privacy (n=295, 38.3%) and comfort (n=269, 34.9%) are among the most frequent reasons for women from France to choose telemedicine abortion through WoW. The COVID-19 pandemic seems to be an important driver for resorting to telemedicine (n=236, 30.6%). The lockdowns had a significant impact on the number of consultations received at WoW from France, increasing from 60 in March to 128 in April during the first lockdown and from 54 in October to 80 in November during the second lockdown.\n\nThe demand for at-home medical abortion via teleconsultation increased in France during the lockdowns. However, drivers of telemedicine abortion are multidimensional and go beyond the conditions unique to the pandemic.", "doi": "10.1136/bmjsrh-2021-201176", "pmid": "34321255", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjsrh-2021-201176"}], "notes": [], "created": "2021-08-04T17:09:36.988Z", "modified": "2021-08-04T17:09:37.026Z"}, {"entity": "publication", "iuid": "4de11e08768e477eb00fa08e3d787692", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4de11e08768e477eb00fa08e3d787692.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4de11e08768e477eb00fa08e3d787692"}}, "title": "SARS-CoV-2 Spike Protein Extrapolation for COVID Diagnosis and Vaccine Development.", "authors": [{"family": "Malik", "given": "Yashpal S", "initials": "YS"}, {"family": "Kumar", "given": "Prashant", "initials": "P"}, {"family": "Ansari", "given": "Mohd Ikram", "initials": "MI"}, {"family": "Hemida", "given": "Maged G", "initials": "MG"}, {"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME"}, {"family": "Abdel-Moneim", "given": "Ahmed S", "initials": "AS"}, {"family": "Ganesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Salajegheh", "given": "Sina", "initials": "S"}, {"family": "Natesan", "given": "Senthilkumar", "initials": "S"}, {"family": "Sircar", "given": "Shubhankar", "initials": "S"}, {"family": "Safdar", "given": "Muhammad", "initials": "M"}, {"family": "Vinodhkumar", "given": "O R", "initials": "OR"}, {"family": "Duarte", "given": "Phelipe M", "initials": "PM"}, {"family": "Patel", "given": "Shailesh K", "initials": "SK"}, {"family": "Klein", "given": "J\u00f6rn", "initials": "J"}, {"family": "Rahimi", "given": "Parastoo", "initials": "P"}, {"family": "Dhama", "given": "Kuldeep", "initials": "K"}], "type": "journal article", "published": "2021-07-28", "journal": {"title": "Front. Mol. Biosci.", "issn": "2296-889X", "volume": "8", "pages": "607886", "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to coronavirus disease 2019 (COVID-19) pandemic affecting nearly 71.2 million humans in more than 191 countries, with more than 1.6 million mortalities as of 12 December, 2020. The spike glycoprotein (S-protein), anchored onto the virus envelope, is the trimer of S-protein comprised of S1 and S2 domains which interacts with host cell receptors and facilitates virus-cell membrane fusion. The S1 domain comprises of a receptor binding domain (RBD) possessing an N-terminal domain and two subdomains (SD1 and SD2). Certain regions of S-protein of SARS-CoV-2 such as S2 domain and fragment of the RBD remain conserved despite the high selection pressure. These conserved regions of the S-protein are extrapolated as the potential target for developing molecular diagnostic techniques. Further, the S-protein acts as an antigenic target for different serological assay platforms for the diagnosis of COVID-19. Virus-specific IgM and IgG antibodies can be used to detect viral proteins in ELISA and lateral flow immunoassays. The S-protein of SARS-CoV-2 has very high sequence similarity to SARS-CoV-1, and the monoclonal antibodies (mAbs) against SARS-CoV-1 cross-react with S-protein of SARS-CoV-2 and neutralize its activity. Furthermore, in vitro studies have demonstrated that polyclonal antibodies targeted against the RBD of S-protein of SARS-CoV-1 can neutralize SARS-CoV-2 thus inhibiting its infectivity in permissive cell lines. Research on coronaviral S-proteins paves the way for the development of vaccines that may prevent SARS-CoV-2 infection and alleviate the current global coronavirus pandemic. However, specific neutralizing mAbs against SARS-CoV-2 are in clinical development. Therefore, neutralizing antibodies targeting SARS-CoV-2 S-protein are promising specific antiviral therapeutics for pre-and post-exposure prophylaxis and treatment of SARS-CoV-2 infection. We hereby review the approaches taken by researchers across the world to use spike gene and S-glycoprotein for the development of effective diagnostics, vaccines and therapeutics against SARA-CoV-2 infection the COVID-19 pandemic.", "doi": "10.3389/fmolb.2021.607886", "pmid": "34395515", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8355592"}], "notes": [], "created": "2021-08-17T06:42:35.226Z", "modified": "2021-08-17T06:42:35.238Z"}, {"entity": "publication", "iuid": "5b83a052d34a4d6c8974f2c1df4b38e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5b83a052d34a4d6c8974f2c1df4b38e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5b83a052d34a4d6c8974f2c1df4b38e8"}}, "title": "High-flow nasal oxygen (HFNO) for patients with Covid-19 outside intensive care units.", "authors": [{"family": "Issa", "given": "Issa", "initials": "I"}, {"family": "S\u00f6derberg", "given": "M\u00e5rten", "initials": "M"}], "type": "journal article", "published": "2021-07-28", "journal": {"title": "Respir Med", "issn": "1532-3064", "volume": "187", "pages": "106554", "issn-l": "0954-6111"}, "abstract": "High-flow nasal oxygen (HFNO) has traditionally only been used in intensive care units (ICU) especially in acute respiratory distress syndrome (ARDS).\n\nWe studied the use of HFNO at S\u00f6dersjukhuset, Stockholm, in patients with moderate to severe ARDS related to Covid-19 as well as its benefits both for patients and to offload the ICU. The patients were observed with frequent controls to assess the need of ICU in case of deterioration.\n\nWe studied 41 patients with HFNO treatment either as primarily treatment (Step-Up) or after stabilizing in the ICU (Step-Down). The average duration for treatment with HFNO was 5.6 days. Of these patients 55% were discharged home or to geriatric rehabilitation and 10% avoided ICU completely. The usage of HFNO saved in total 229 days in the ICU. Mortality was higher among elderly patients, and patients with comorbidities (mainly hypertension and obesity).\n\nHFNO treatment is feasible and efficient for patients with Covid-19, saving resources in the ICU and offering additional advantages as waken proning and fewer complications compared to traditional ICU care. It requires however frequent controls as deterioration is recurrent.", "doi": "10.1016/j.rmed.2021.106554", "pmid": "34340173", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0954-6111(21)00260-2"}], "notes": [], "created": "2021-08-04T10:10:08.771Z", "modified": "2021-08-04T10:10:08.782Z"}, {"entity": "publication", "iuid": "90f29222ad714723bbd9ced04cad354e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90f29222ad714723bbd9ced04cad354e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90f29222ad714723bbd9ced04cad354e"}}, "title": "Risk perception, treatment adherence, and personality during COVID-19 pandemic: An international study on cancer patients.", "authors": [{"family": "Cheli", "given": "Simone", "initials": "S", "orcid": "0000-0002-0432-3769", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d454912b2b7463e9f09b0c32954570f.json"}}, {"family": "Lam", "given": "Wendy W T", "initials": "WWT", "orcid": "0000-0003-2383-0149", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72b193d3e93e4db0b1b69bcf36e8199e.json"}}, {"family": "Estap\u00e9", "given": "Tania", "initials": "T", "orcid": "0000-0001-9792-2586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28a910dd36ee4e51947763acf49bd12b.json"}}, {"family": "Winterling", "given": "Jeanette", "initials": "J", "orcid": "0000-0003-4165-9015", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/334f6c0ee8d047b88231d04d2b148e45.json"}}, {"family": "Bahcivan", "given": "Ozan", "initials": "O"}, {"family": "Andritsch", "given": "Elisabeth", "initials": "E"}, {"family": "Weis", "given": "Joachim", "initials": "J", "orcid": "0000-0002-8646-6607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/38e0112be6eb448f821b51aab7e439d3.json"}}, {"family": "Centeno", "given": "Isabel", "initials": "I"}, {"family": "Serpentini", "given": "Samantha", "initials": "S", "orcid": "0000-0002-0517-3416", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/731e1839e02544c38db8553cab833149.json"}}, {"family": "Farkas", "given": "Clemens", "initials": "C"}, {"family": "Wengstr\u00f6m", "given": "Yvonne", "initials": "Y"}, {"family": "Fioretto", "given": "Luisa", "initials": "L"}, {"family": "Baider", "given": "Lea", "initials": "L"}, {"family": "Lam", "given": "Cherry C L", "initials": "CCL"}, {"family": "Goldzweig", "given": "Gil", "initials": "G", "orcid": "0000-0003-2295-1627", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5adb0c7e08ff46938308ba55a450ddee.json"}}], "type": "journal article", "published": "2021-07-27", "journal": {"title": "Psychooncology", "issn": "1099-1611", "issn-l": null}, "abstract": "To explore the role of personality traits in moderating the relation between COVID-19 risk perception and treatment adherence, and between risk perception and psychosocial distress in patients diagnosed with cancer.\n\nAn online survey (n = 1281) was conducted worldwide in seven countries (Austria, Germany, Hong Kong, Italy, Spain, Sweden, and Turkey). Inclusion criteria were to be 18 years of age or older, have received a cancer diagnosis, and be in treatment or follow-up. A few moderated regression models were performed with both personality traits and Hierarchical Taxonomy of Psychopathology super-spectra as moderators.\n\nDetachment, negative affectivity, psychoticism and all the super-spectra significantly moderated the relation between coronavirus risk perception and psychosocial distress, after the adjusting effect of confidence in safeguards. Only negative affectivity moderated the association between coronavirus risk perception and treatment adherence.\n\nPersonality traits may foster the understanding of how a patient might adjust to cancer treatment and, more generically, to highly stressful events such as the COVID-19 pandemic. Further research is needed to confirm the results in different cancer stages and types.", "doi": "10.1002/pon.5775", "pmid": "34314560", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-05T06:49:17.670Z", "modified": "2021-08-05T06:49:56.380Z"}, {"entity": "publication", "iuid": "874dc3a385944b54abd448b449c42852", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/874dc3a385944b54abd448b449c42852.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/874dc3a385944b54abd448b449c42852"}}, "title": "Insomnia episodes, new-onset pharmacological treatments and other sleep disturbances during the COVID-19 pandemic: a nationwide cross-sectional study in Brazilian health care professionals.", "authors": [{"family": "Drager", "given": "Luciano F", "initials": "LF"}, {"family": "Pachito", "given": "Daniela V", "initials": "DV"}, {"family": "Moreno", "given": "Claudia R C", "initials": "CRC"}, {"family": "Tavares", "given": "Almir R", "initials": "AR"}, {"family": "Conway", "given": "Silvia G", "initials": "SG"}, {"family": "Assis", "given": "M\u00e1rcia", "initials": "M"}, {"family": "Sguillar", "given": "Danilo A", "initials": "DA"}, {"family": "Moreira", "given": "Gustavo A", "initials": "GA"}, {"family": "Bacelar", "given": "Andrea", "initials": "A"}, {"family": "Genta", "given": "Pedro R", "initials": "PR"}], "type": "journal article", "published": "2021-07-27", "journal": {"title": "J Clin Sleep Med", "issn": "1550-9397", "issn-l": null}, "abstract": "To evaluate the impact of COVID-19 pandemic on insomnia and other sleep disturbances in health care professionals.\n\nA survey was distributed using social media and organizational emails to Brazilian active health care professionals during the COVID-19 outbreak. We explored potential associated factors including age, gender, occupation, workplace, work hours, income, previous infection with COVID-19, recent/current contact with COVID-19 patients, regional number of incident deaths, anxiety, and burnout. We evaluated new-onset/ previous insomnia worsening episodes (primary outcome), new pharmacological treatments, sleep quality, duration, nightmares and snoring (secondary outcomes).\n\nA total of 4,384 health professionals from all regions of the country were included in the analysis (44\u00b112 years, 76% females, 53.8% physicians). Overall, 55.7% were assisting patients with COVID-19, and 9.2% had a previous COVID-19 infection. The primary outcome occurred in 32.9% of respondents in parallel to 13% new pharmacological treatments for insomnia. The sleep quality worsened for 61.4%, while 43.5% and 22.8% reported \u22651-hour sleep duration reduction and worsening or new-onset nightmares, respectively. Multivariate analyses showed that age (OR:1.008; 95% CI 1.001-1.015), females (OR:1.590; 95% CI 1.335-1.900), weight change (decrease: OR:1.772; 95% CI 1.453-2.161; increase: OR:1.468; 95% CI 1.249-1.728), prevalent anxiety (OR:3.414; 95% CI 2.954-3.948), new-onset burnout (OR:1.761; 95% CI 1.489-2.083), family income reduction >30% (OR:1.288; 95% CI 1.069-1.553) and assisting patients with COVID-19 (OR:1.275; 95% CI 1.081-1.506) were independently associated with new-onset or worsening of previous insomnia episodes.\n\nWe observed a huge burden of insomnia episodes and other sleep disturbances in health care professionals during the COVID-19 pandemic.", "doi": "10.5664/jcsm.9570", "pmid": "34314346", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-05T06:50:22.198Z", "modified": "2021-11-18T12:41:20.850Z"}, {"entity": "publication", "iuid": "6c0622945cb14014a699e3ce3788c348", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c0622945cb14014a699e3ce3788c348.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c0622945cb14014a699e3ce3788c348"}}, "title": "Impact of tiered restrictions on human activities and the epidemiology of the second wave of COVID-19 in Italy.", "authors": [{"family": "Manica", "given": "Mattia", "initials": "M", "orcid": "0000-0003-3709-1199", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f1dee2cd796464983ca73416f1ba644.json"}}, {"family": "Guzzetta", "given": "Giorgio", "initials": "G"}, {"family": "Riccardo", "given": "Flavia", "initials": "F", "orcid": "0000-0002-1582-6329", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db383a5731dd4bb1aa8ff4c1cac91455.json"}}, {"family": "Valenti", "given": "Antonio", "initials": "A"}, {"family": "Poletti", "given": "Piero", "initials": "P", "orcid": "0000-0001-5453-5199", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e47d12a6b4954f45b9cf7c10f53aea19.json"}}, {"family": "Marziano", "given": "Valentina", "initials": "V", "orcid": "0000-0003-2842-7906", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9548ac3b58a249708f9ad8a835f42794.json"}}, {"family": "Trentini", "given": "Filippo", "initials": "F", "orcid": "0000-0001-6915-7282", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1ef47385a014489af492240312faded.json"}}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A", "orcid": "0000-0002-0480-8723", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96fca74501fd40f59359426781336b42.json"}}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Vescio", "given": "Maria Fenicia", "initials": "MF", "orcid": "0000-0002-3285-919X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fb4525bc8684390b022335a044b9db8.json"}}, {"family": "Spuri", "given": "Matteo", "initials": "M"}, {"family": "Petrone", "given": "Daniele", "initials": "D"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Iavicoli", "given": "Sergio", "initials": "S"}, {"family": "Ajelli", "given": "Marco", "initials": "M", "orcid": "0000-0003-1753-4749", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e1711c9d1c04770b118631d74173efd.json"}}, {"family": "Brusaferro", "given": "Silvio", "initials": "S"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P", "orcid": "0000-0002-0805-2927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/95cf0a950b334a61a4420f778420d114.json"}}, {"family": "Merler", "given": "Stefano", "initials": "S", "orcid": "0000-0002-5117-0611", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/380ed711c37a41e49c4b4f53ab0636af.json"}}], "type": "journal article", "published": "2021-07-27", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "4570", "issn-l": "2041-1723"}, "abstract": "To counter the second COVID-19 wave in autumn 2020, the Italian government introduced a system of physical distancing measures organized in progressively restrictive tiers (coded as yellow, orange, and red) imposed on a regional basis according to real-time epidemiological risk assessments. We leverage the data from the Italian COVID-19 integrated surveillance system and publicly available mobility data to evaluate the impact of the three-tiered regional restriction system on human activities, SARS-CoV-2 transmissibility and hospitalization burden in Italy. The individuals' attendance to locations outside the residential settings was progressively reduced with tiers, but less than during the national lockdown against the first COVID-19 wave in the spring. The reproduction number R(t) decreased below the epidemic threshold in 85 out of 107 provinces after the introduction of the tier system, reaching average values of about 0.95-1.02 in the yellow tier, 0.80-0.93 in the orange tier and 0.74-0.83 in the red tier. We estimate that the reduced transmissibility resulted in averting about 36% of the hospitalizations between November 6 and November 25, 2020. These results are instrumental to inform public health efforts aimed at preventing future resurgence of cases.", "doi": "10.1038/s41467-021-24832-z", "pmid": "34315899", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-24832-z"}, {"db": "pmc", "key": "PMC8316570"}, {"db": "URL", "key": "https://doi.org/10.6084/m9.figshare.14153351.v1", "description": "Mobility and epidemiological data"}], "notes": [], "created": "2021-08-05T06:48:17.298Z", "modified": "2021-11-18T12:40:09.354Z"}, {"entity": "publication", "iuid": "e6060ed659914e25af19d827947cbde6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6060ed659914e25af19d827947cbde6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6060ed659914e25af19d827947cbde6"}}, "title": "Emergence of an early SARS-CoV-2 epidemic in the United States.", "authors": [{"family": "Zeller", "given": "Mark", "initials": "M"}, {"family": "Gangavarapu", "given": "Karthik", "initials": "K"}, {"family": "Anderson", "given": "Catelyn", "initials": "C"}, {"family": "Smither", "given": "Allison R", "initials": "AR"}, {"family": "Vanchiere", "given": "John A", "initials": "JA"}, {"family": "Rose", "given": "Rebecca", "initials": "R"}, {"family": "Snyder", "given": "Daniel J", "initials": "DJ"}, {"family": "Dudas", "given": "Gytis", "initials": "G"}, {"family": "Watts", "given": "Alexander", "initials": "A"}, {"family": "Matteson", "given": "Nathaniel L", "initials": "NL"}, {"family": "Robles-Sikisaka", "given": "Refugio", "initials": "R"}, {"family": "Marshall", "given": "Maximilian", "initials": "M"}, {"family": "Feehan", "given": "Amy K", "initials": "AK"}, {"family": "Sabino-Santos", "given": "Gilberto", "initials": "G"}, {"family": "Bell-Kareem", "given": "Antoinette R", "initials": "AR"}, {"family": "Hughes", "given": "Laura D", "initials": "LD"}, {"family": "Alkuzweny", "given": "Manar", "initials": "M"}, {"family": "Snarski", "given": "Patricia", "initials": "P"}, {"family": "Garcia-Diaz", "given": "Julia", "initials": "J"}, {"family": "Scott", "given": "Rona S", "initials": "RS"}, {"family": "Melnik", "given": "Lilia I", "initials": "LI"}, {"family": "Klitting", "given": "Rapha\u00eblle", "initials": "R"}, {"family": "McGraw", "given": "Michelle", "initials": "M"}, {"family": "Belda-Ferre", "given": "Pedro", "initials": "P"}, {"family": "DeHoff", "given": "Peter", "initials": "P"}, {"family": "Sathe", "given": "Shashank", "initials": "S"}, {"family": "Marotz", "given": "Clarisse", "initials": "C"}, {"family": "Grubaugh", "given": "Nathan D", "initials": "ND"}, {"family": "Nolan", "given": "David J", "initials": "DJ"}, {"family": "Drouin", "given": "Arnaud C", "initials": "AC"}, {"family": "Genemaras", "given": "Kaylynn J", "initials": "KJ"}, {"family": "Chao", "given": "Karissa", "initials": "K"}, {"family": "Topol", "given": "Sarah", "initials": "S"}, {"family": "Spencer", "given": "Emily", "initials": "E"}, {"family": "Nicholson", "given": "Laura", "initials": "L"}, {"family": "Aigner", "given": "Stefan", "initials": "S"}, {"family": "Yeo", "given": "Gene W", "initials": "GW"}, {"family": "Farnaes", "given": "Lauge", "initials": "L"}, {"family": "Hobbs", "given": "Charlotte A", "initials": "CA"}, {"family": "Laurent", "given": "Louise C", "initials": "LC"}, {"family": "Knight", "given": "Rob", "initials": "R"}, {"family": "Hodcroft", "given": "Emma B", "initials": "EB"}, {"family": "Khan", "given": "Kamran", "initials": "K"}, {"family": "Fusco", "given": "Dahlene N", "initials": "DN"}, {"family": "Cooper", "given": "Vaughn S", "initials": "VS"}, {"family": "Lemey", "given": "Phillipe", "initials": "P"}, {"family": "Gardner", "given": "Lauren", "initials": "L"}, {"family": "Lamers", "given": "Susanna L", "initials": "SL"}, {"family": "Kamil", "given": "Jeremy P", "initials": "JP"}, {"family": "Garry", "given": "Robert F", "initials": "RF"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Andersen", "given": "Kristian G", "initials": "KG"}], "type": "journal article", "published": "2021-07-27", "journal": {"title": "Cell", "issn": "1097-4172", "issn-l": "0092-8674"}, "abstract": "The emergence of the COVID-19 epidemic in the United States (U.S.) went largely undetected due to inadequate testing. New Orleans experienced one of the earliest and fastest accelerating outbreaks, coinciding with Mardi Gras. To gain insight into the emergence of SARS-CoV-2 in the U.S. and how large-scale events accelerate transmission, we sequenced SARS-CoV-2 genomes during the first wave of the COVID-19 epidemic in Louisiana. We show that SARS-CoV-2 in Louisiana had limited diversity compared to other U.S. states and that one introduction of SARS-CoV-2 led to almost all of the early transmission in Louisiana. By analyzing mobility and genomic data, we show that SARS-CoV-2 was already present in New Orleans before Mardi Gras, and the festival dramatically accelerated transmission. Our study provides an understanding of how superspreading during large-scale events played a key role during the early outbreak in the U.S. and can greatly accelerate epidemics.", "doi": "10.1016/j.cell.2021.07.030", "pmid": "34508652", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "S0092-8674(21)00889-8"}], "notes": [], "created": "2021-09-13T06:27:48.982Z", "modified": "2021-09-13T06:28:12.476Z"}, {"entity": "publication", "iuid": "744226cc5c5144879e5767e369df749d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/744226cc5c5144879e5767e369df749d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/744226cc5c5144879e5767e369df749d"}}, "title": "Publisher Correction: A SARS-CoV-2 (COVID-19) biological network to find targets for drug repurposing.", "authors": [{"family": "Habibi", "given": "Mahnaz", "initials": "M"}, {"family": "Taheri", "given": "Golnaz", "initials": "G"}, {"family": "Aghdam", "given": "Rosa", "initials": "R"}], "type": "published erratum", "published": "2021-07-26", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "15550", "issn-l": "2045-2322"}, "abstract": null, "doi": "10.1038/s41598-021-94440-w", "pmid": "34312434", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-94440-w"}, {"db": "pmc", "key": "PMC8312203"}], "notes": [], "created": "2021-08-05T06:51:19.646Z", "modified": "2021-08-05T06:51:32.486Z"}, {"entity": "publication", "iuid": "26ad1c470c1947dd88ed132b5289fe00", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26ad1c470c1947dd88ed132b5289fe00.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26ad1c470c1947dd88ed132b5289fe00"}}, "title": "Gambling-Like Day Trading During the COVID-19 Pandemic \u2013 Need for Research on a Pandemic-Related Risk of Indebtedness and Mental Health Impact", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "Fern\u00e1ndez-Aranda", "given": "Fernando", "initials": "F"}, {"family": "Jim\u00e9nez-Murcia", "given": "Susana", "initials": "S"}], "type": "journal-article", "published": "2021-07-26", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "issn-l": "1664-0640"}, "abstract": null, "doi": "10.3389/fpsyt.2021.715946", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-12T17:08:51.507Z", "modified": "2021-08-12T17:08:51.518Z"}, {"entity": "publication", "iuid": "be66ed79c9a94526a346fadd6606bbda", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be66ed79c9a94526a346fadd6606bbda.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be66ed79c9a94526a346fadd6606bbda"}}, "title": "Echocardiographic characterisation in critical Covid19 - an observational study", "authors": [{"family": "Isackson", "given": "Henrik", "initials": "H"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Flachskampf", "given": "Frank A", "initials": "FA"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}], "type": "posted-content", "published": "2021-07-26", "journal": {"title": "MedRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.07.23.21261025", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [], "notes": [], "created": "2021-08-03T11:38:30.872Z", "modified": "2022-02-09T10:24:26.569Z"}, {"entity": "publication", "iuid": "52a5191b1d05485fbf2afe5aa5526c84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/52a5191b1d05485fbf2afe5aa5526c84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/52a5191b1d05485fbf2afe5aa5526c84"}}, "title": "Detection and viral RNA shedding of SARS-CoV-2 in respiratory specimens relative to symptom onset among COVID-19 patients in Bavaria, Germany - Addendum.", "authors": [{"family": "Woudenberg", "given": "Tom", "initials": "T"}, {"family": "Eberle", "given": "Ute", "initials": "U"}, {"family": "Marosevic", "given": "Durdica", "initials": "D"}, {"family": "Liebl", "given": "Bernhard", "initials": "B"}, {"family": "Ackermann", "given": "Nikolaus", "initials": "N"}, {"family": "Katz", "given": "Katharina", "initials": "K"}, {"family": "Sing", "given": "Andreas", "initials": "A"}, {"family": "Bavarian SARS-CoV-2-Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-07-26", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": "149", "pages": "e167", "issn-l": null}, "abstract": null, "doi": "10.1017/S095026882100159X", "pmid": "34308806", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8314188"}, {"db": "pii", "key": "S095026882100159X"}], "notes": [], "created": "2021-08-05T06:52:32.877Z", "modified": "2023-06-19T15:23:43.663Z"}, {"entity": "publication", "iuid": "510a4bcdc52d4274b4982a084c7413ed", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/510a4bcdc52d4274b4982a084c7413ed.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/510a4bcdc52d4274b4982a084c7413ed"}}, "title": "Depressive symptoms and perception of risk during the first wave of the COVID-19 pandemic: A web-based cross-country comparative survey.", "authors": [{"family": "Terraneo", "given": "Marco", "initials": "M", "orcid": "0000-0003-1072-2923", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8940f795351451582749a735ac7d10e.json"}}, {"family": "Lombi", "given": "Linda", "initials": "L"}, {"family": "Bradby", "given": "Hannah", "initials": "H", "orcid": "0000-0002-0664-1170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6650bd723f06404cb9f068d9bda13541.json"}}], "type": "journal article", "published": "2021-07-26", "journal": {"title": "Sociol Health Illn", "issn": "1467-9566", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Evidence is accumulating of the negative impact of the COVID-19 pandemic and related public health measures on mental health. In this emergent field, there has been little research into the role of risk perception on depressive symptoms and the contribution of health-care resources to model risk perception and mental health. The aim of this paper is to describe the relationship between individual-level perception of risk and depression, controlling for a set of confounders and for country-level heterogeneity. A cross-sectional and observational online survey was conducted using a non-probability snowball sampling technique. We use data on 11,340 respondents, living in six European countries (Italy, Sweden, United Kingdom, France, Poland, Czech Republic) who completed survey questionnaires during the first months of the pandemic. We used a fixed-effect approach, which included individual and macro-level variables. The findings suggest that a high proportion of people suffering from depression and heightened risk perception is positively associated with reporting depressive symptoms, even if this relationship varies significantly between countries. Moreover, the association is moderated by contextual factors including health-care expenditure as a percentage of Gross Domestic Product, hospital beds for acute care, and number of medical specialists per head of population. Investment in health care offers a concrete means of protecting the mental health of a population living under pandemic restrictions.", "doi": "10.1111/1467-9566.13350", "pmid": "34309032", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-05T06:52:12.792Z", "modified": "2021-11-18T12:06:01.508Z"}, {"entity": "publication", "iuid": "9f1ffdda0e594d7d91e8fb212c9f63a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f1ffdda0e594d7d91e8fb212c9f63a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f1ffdda0e594d7d91e8fb212c9f63a0"}}, "title": "Conditions and strategies to meet the challenges imposed by the COVID-19-related visiting restrictions in the intensive care unit: A Scandinavian cross-sectional study.", "authors": [{"family": "Jensen", "given": "Hanne Irene", "initials": "HI"}, {"family": "\u00c5kerman", "given": "Eva", "initials": "E"}, {"family": "Lind", "given": "Ranveig", "initials": "R"}, {"family": "Alfheim", "given": "Hanne Birgit", "initials": "HB"}, {"family": "Frivold", "given": "Gro", "initials": "G"}, {"family": "Fridh", "given": "Isabell", "initials": "I"}, {"family": "\u00c5g\u00e5rd", "given": "Anne Sophie", "initials": "AS"}], "type": "journal article", "published": "2021-07-26", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "issn-l": null, "volume": null, "issue": null, "pages": "103116"}, "abstract": "To examine conditions and strategies to meet the challenges imposed by the coronavirus disease 2019 (COVID-19)-related visiting restrictions in Scandinavian intensive care units.\r\n\r\nA cross-sectional survey.\r\n\r\nAdult intensive care units in Denmark, Norway and Sweden.\r\n\r\nLikert scale responses and free-text comments within six areas: capacity and staffing, visiting policies and access to the unit, information and conferences with relatives, written information, children as relatives and follow-up initiatives.\r\n\r\nThe overall response rate was 53% (74/140 participating units). All intensive care units had planned for capacity extensions; the majority ranging between 11 and 30 extra beds. From March-June 2020, units had a mean maximum of 9.4 COVID-19 patients simultaneously. Allowing restricted visiting was more common in Denmark (52%) and Norway (61%) than in Sweden where visiting was mostly denied except for dying patients (68%), due to a particular increased number of COVID-19 patients. The restrictions forced nurses to compromise on their usual standards of family care. Numerous models for maintaining contact between relatives and patients were described.\r\n\r\nVisitation restrictions compromised the quality of family care and entailed dilemmas for healthcare professionals but also spurred initiatives to developing new ways of providing family care.", "doi": "10.1016/j.iccn.2021.103116", "pmid": "34391628", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(21)00105-1"}], "notes": [], "created": "2021-08-16T09:32:10.498Z", "modified": "2021-11-18T11:59:47.254Z"}, {"entity": "publication", "iuid": "1ccaf39e6fd54c4282412ead18d1c405", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ccaf39e6fd54c4282412ead18d1c405.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ccaf39e6fd54c4282412ead18d1c405"}}, "title": "Recurrent and persistent infection with SARS-CoV-2 - epidemiological data and case reports from Western Sweden, 2020.", "authors": [{"family": "Ringlander", "given": "Johan", "initials": "J", "orcid": "0000-0002-8483-6504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64f85af7dceb436498422e62f1a98c89.json"}}, {"family": "Olausson", "given": "Josefin", "initials": "J"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "H\u00e4rnqvist", "given": "Tor", "initials": "T"}, {"family": "Jakobsson", "given": "Hedvig E", "initials": "HE"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-07-24", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": null, "issue": null, "pages": "1-8"}, "abstract": "Reinfections with SARS-CoV-2 have been reported and most cases were classified as mild. Reports of persistent infection with SARS-CoV-2 are rare.\r\n\r\nTo investigate the frequency of recurrent and persistent infection with SARS-CoV-2.\r\n\r\nPossible cases of reinfection and persistent infection were retrospectively identified in a database of 59,998 patients. Deep sequencing of SARS-CoV-2 genomes was performed.\r\n\r\nWe report the first case of COVID-19 reinfection in Sweden and three cases of infection with persistence over several months. The rate of sequencing-verified reinfection was 0.02% (one patient out of 6014 patients testing positive during the period).\r\n\r\nThe reinfected patient had mild symptoms during the second episode, which might reflect partial immunity. The frequency of reinfection during the first wave of the pandemic in western Sweden was very low. Our results indicate that elderly with a putative reinfection more likely have persistent COVID-19.", "doi": "10.1080/23744235.2021.1957143", "pmid": "34308755", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "URL", "key": "https://www.tandfonline.com/doi/figure/10.1080/23744235.2021.1957143?scroll=top&needAccess=true", "description": "Nucleotide differences between the first infection and second infection strains from one patient with reinfection"}], "notes": [], "created": "2021-08-05T06:52:53.774Z", "modified": "2021-11-18T11:56:46.277Z"}, {"entity": "publication", "iuid": "d585588f3a9c4c0aac93cdf21af3264f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d585588f3a9c4c0aac93cdf21af3264f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d585588f3a9c4c0aac93cdf21af3264f"}}, "title": "Profiling lockdown adherence and poor coping responses towards the COVID-19 crisis in an international cross-sectional survey", "authors": [{"family": "Van Belle", "given": "Sylvia", "initials": "S", "orcid": "0000-0002-6247-5832", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bffd346b0f96471e9b815246904378e8.json"}}, {"family": "Dahl\u00e9n", "given": "Amelia", "initials": "A"}, {"family": "Schi\u00f6th", "given": "Helgi B", "initials": "HB", "orcid": "0000-0001-7112-0921", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ec43532c42c4ee5b79a470fede7d088.json"}}, {"family": "Brooks", "given": "Samantha J", "initials": "SJ", "orcid": "0000-0002-9146-6257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef6c03915d334cd3bbefbe6508397561.json"}}], "type": "posted-content", "published": "2021-07-24", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.07.21.21260910", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-08-03T11:41:30.941Z", "modified": "2021-11-19T11:26:33.994Z"}, {"entity": "publication", "iuid": "e97f8e5f6fd241c2bdd9c2ae9b51e552", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e97f8e5f6fd241c2bdd9c2ae9b51e552.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e97f8e5f6fd241c2bdd9c2ae9b51e552"}}, "title": "Pandemic backsliding: Violations of democratic standards during Covid-19.", "authors": [{"family": "Edgell", "given": "Amanda B", "initials": "AB"}, {"family": "Lachapelle", "given": "Jean", "initials": "J"}, {"family": "L\u00fchrmann", "given": "Anna", "initials": "A"}, {"family": "Maerz", "given": "Seraphine F", "initials": "SF"}], "type": "journal article", "published": "2021-07-24", "journal": {"title": "Soc Sci Med", "issn": "1873-5347", "issn-l": null, "volume": "285", "issue": null, "pages": "114244"}, "abstract": "The widespread adoption of emergency powers during Covid-19 raises important questions about what constitutes a (un)democratic response to crises. While the institutions and practices of democracy during normal times are well established, democratic standards during emergencies have yet to be conceptualized in the literature. This makes it difficult to systematically answer questions like - How do states' responses to Covid-19 violate democratic standards? Do such violations make states' responses more effective? Drawing on international treaties, norms, and academic scholarship, we propose a novel conceptualization of democratic standards for emergency measures. We then identify which government responses to Covid-19 qualify as a violation of democratic standards within the framework of illiberal and authoritarian practices, introducing a dataset covering 144 countries from March 2020 onward. In this article, we provide an overview of the extent to which states violated democratic standards in their response to Covid-19 during 2020. We find no relationship between violations of democratic standards and reported Covid-19 mortality. Illiberal and authoritarian practices in response to the Covid-19 pandemic do not correlate with better public health outcomes. Rather, such crisis-driven violations should be carefully observed as they could signal autocratization.", "doi": "10.1016/j.socscimed.2021.114244", "pmid": "34399291", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0277-9536(21)00576-1"}], "notes": [], "created": "2021-08-17T06:41:22.807Z", "modified": "2022-11-23T08:54:57.436Z"}, {"entity": "publication", "iuid": "9b812d6e85c049a1a63606067812fe0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b812d6e85c049a1a63606067812fe0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b812d6e85c049a1a63606067812fe0e"}}, "title": "Federated Semi-Supervised Multi-Task Learning to Detect COVID-19 and Lungs Segmentation Marking Using Chest Radiography Images and Raspberry Pi Devices: An Internet of Medical Things Application.", "authors": [{"family": "Alam", "given": "Mahbub Ul", "initials": "MU", "orcid": "0000-0002-1101-3793", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d29bbd8d865401b8d0ef481eb80d6e2.json"}}, {"family": "Rahmani", "given": "Rahim", "initials": "R", "orcid": "0000-0001-5924-5457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bf1ae3967524119a9b97042d8ef16b3.json"}}], "type": "journal article", "published": "2021-07-24", "journal": {"title": "Sensors (Basel)", "issn": "1424-8220", "volume": "21", "issue": "15", "issn-l": null}, "abstract": "Internet of Medical Things (IoMT) provides an excellent opportunity to investigate better automatic medical decision support tools with the effective integration of various medical equipment and associated data. This study explores two such medical decision-making tasks, namely COVID-19 detection and lung area segmentation detection, using chest radiography images. We also explore different cutting-edge machine learning techniques, such as federated learning, semi-supervised learning, transfer learning, and multi-task learning to explore the issue. To analyze the applicability of computationally less capable edge devices in the IoMT system, we report the results using Raspberry Pi devices as accuracy, precision, recall, Fscore for COVID-19 detection, and average dice score for lung segmentation detection tasks. We also publish the results obtained through server-centric simulation for comparison. The results show that Raspberry Pi-centric devices provide better performance in lung segmentation detection, and server-centric experiments provide better results in COVID-19 detection. We also discuss the IoMT application-centric settings, utilizing medical data and decision support systems, and posit that such a system could benefit all the stakeholders in the IoMT domain.", "doi": "10.3390/s21155025", "pmid": "34372262", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "s21155025"}], "notes": [], "created": "2021-08-11T14:33:34.731Z", "modified": "2021-08-11T14:33:34.806Z"}, {"entity": "publication", "iuid": "44ae53d507a24f2ba8d79d4ca1bf93da", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44ae53d507a24f2ba8d79d4ca1bf93da.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44ae53d507a24f2ba8d79d4ca1bf93da"}}, "title": "Depression, anxiety and stress among Swedish university students during the second and third waves of COVID-19: A cohort study.", "authors": [{"family": "Johansson", "given": "Fred", "initials": "F", "orcid": "0000-0001-9717-0935", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e23a51cd8dc4d1da5032559b08fddd9.json"}}, {"family": "C\u00f4t\u00e9", "given": "Pierre", "initials": "P"}, {"family": "Hogg-Johnson", "given": "Sheilah", "initials": "S"}, {"family": "Skillgate", "given": "Eva", "initials": "E"}], "type": "journal article", "published": "2021-07-24", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": null, "issue": null, "pages": "14034948211031402"}, "abstract": "This study aims to describe the mean trajectories of depression, anxiety and stress symptoms among Swedish university students before and during the second and third waves of the COVID-19 pandemic.\r\n\r\nWe recruited 1835 participants in September 2020, of whom 81% provided follow-ups in December 2020-January 2021 and 77% provided follow-ups in March-April 2021. The short-form Depression, Anxiety and Stress Scale was used to measure mental health symptoms. Generalized estimating equations were used to estimate the mean differences in symptom levels over the three time periods.\r\n\r\nCompared with September, mean depression was 0.91 points of 21 higher (95% confidence interval (CI) 0.70-1.13) in December 2020-January 2021 and 0.66 points higher (95% CI 0.43-.88) in March-April 2021. Anxiety levels were 0.20 points higher (95% CI 0.05-0.34) in December 2020-January 2021 and 0.17 points higher (95% CI 0.02-0.33) in March-April 2021. Stress levels were 0.21 points higher (95% CI 0.00-0.41) in December 2020-January 2021 and 0.16 points lower (95% CI -0.38 to 0.05) in March-April 2021.\r\n\r\nOur results indicate relatively stable levels of mental health among Swedish university students during the second and third waves of COVID-19 compared with before the second wave. Mean depression symptom scores increased slightly, but the importance of this small increase is uncertain.", "doi": "10.1177/14034948211031402", "pmid": "34304621", "labels": {"Category: Public Health": null, "Type: Journal article": null, "Funder: Forte": null}, "xrefs": [], "notes": [], "created": "2021-08-05T07:01:57.155Z", "modified": "2021-11-18T11:46:25.237Z"}, {"entity": "publication", "iuid": "d1af80ca7b0e42858a06cf240412367a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1af80ca7b0e42858a06cf240412367a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1af80ca7b0e42858a06cf240412367a"}}, "title": "[High correlation between the different measures suggests that mortality is relatively correctly reported in Sweden].", "authors": [{"family": "Kalischer Wellander", "given": "Benjamin", "initials": "B"}, {"family": "L\u00f6tvall", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2021-07-23", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "volume": "118", "issn-l": "0023-7205"}, "abstract": "Infection fatality ratio (IFR) in covid-19 is highly debated in international and Swedish press. In Sweden, three different estimates have been used to estimate mortality, based on statistics either from the Swedish National Board of Health and Welfare, and the Public Health Agency of Sweden, whereas excess mortality calculated by EuroMOMO. Mortality is based on death certificates, which can be accurate or erroneous, but previous analyses have suggested that over- and underdiagnosis usually even out. EuroMOMO on the other hand reports all-cause mortality compared to an estimated baseline. In view of high correlation between the different measures, we suggest that mortality is relatively correctly reported in Sweden. We discuss IFR internationally and in Sweden, and suggest that IFR in the Western world is approximately 0.5-1%. However, these numbers will change over time depending on immunity induced by vaccination efforts, but also the potential spread of new virus variants.", "doi": null, "pmid": "34296754", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "21120"}], "notes": [], "created": "2021-08-05T07:09:48.985Z", "modified": "2021-08-05T07:09:49.008Z"}, {"entity": "publication", "iuid": "a3c910a0c23c46f9bd74172c2e64a432", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3c910a0c23c46f9bd74172c2e64a432.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3c910a0c23c46f9bd74172c2e64a432"}}, "title": "The geography of COVID-19 in Sweden.", "authors": [{"family": "Florida", "given": "Richard", "initials": "R"}, {"family": "Mellander", "given": "Charlotta", "initials": "C", "orcid": "0000-0002-4560-1905", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f4c34f7743b40df8673efcf78c039fc.json"}}], "type": "journal article", "published": "2021-07-23", "journal": {"title": "Ann Reg Sci", "issn": "0570-1864", "pages": "1-26", "issn-l": null}, "abstract": "This paper examines the geographic factors that are associated with the spread of COVID-19 during the first wave in Sweden. We focus particularly on the role of place-based factors versus factors associated with the spread or diffusion of COVID-19 across places. Sweden is a useful case study to examine the interplay of these factors because it did not impose mandatory lockdowns and because there were essentially no regional differences in the pandemic policies or strategies during the first wave of COVID-19. We examine the role of place-based factors like density, age structures and different socioeconomic factors on the geographic variation of COVID-19 cases and on deaths, across both municipalities and neighborhoods. Our findings show that factors associated with diffusion matter more than place-based factors in the geographic incidence of COVID-19 in Sweden. The most significant factor of all is proximity to places with higher levels of infections. COVID-19 is also higher in places that were hit earliest in the outbreak. Of place-based factors, the geographic variation in COVID-19 is most significantly related to the presence of high-risk nursing homes, and only modestly associated with factors like density, population size, income and other socioeconomic characteristics of places.", "doi": "10.1007/s00168-021-01071-0", "pmid": "34316091", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "1071"}, {"db": "pmc", "key": "PMC8299438"}], "notes": [], "created": "2021-08-05T06:47:37.298Z", "modified": "2021-08-05T06:47:37.351Z"}, {"entity": "publication", "iuid": "a5388cc81d2f4c0288d874cf43668310", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a5388cc81d2f4c0288d874cf43668310.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a5388cc81d2f4c0288d874cf43668310"}}, "title": "Housing, sanitation and living conditions affecting SARS-CoV-2 prevention interventions in 54 African countries.", "authors": [{"family": "Brewer", "given": "Timothy F", "initials": "TF", "orcid": "0000-0002-5615-1639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6e0f3db6e834dc3b13f7bb5920f588c.json"}}, {"family": "Zhang", "given": "Mary", "initials": "M", "orcid": "0000-0003-2534-3811", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a481992f82c74686845a5043cad02382.json"}}, {"family": "Gordon", "given": "David", "initials": "D"}, {"family": "Chung", "given": "Roger Yat-Nork", "initials": "RY"}, {"family": "Dejene", "given": "Negussie", "initials": "N"}, {"family": "Fonta", "given": "Cynthia L", "initials": "CL"}, {"family": "Grieve", "given": "Tigist", "initials": "T"}, {"family": "Haller\u00f6d", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Harris", "given": "Richard", "initials": "R"}, {"family": "Lanau", "given": "Alba", "initials": "A", "orcid": "0000-0001-6226-8545", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/da7a6d18caf847e3b424c6dbfd87640b.json"}}, {"family": "Leibbrandt", "given": "Murray", "initials": "M"}, {"family": "Mekonen", "given": "Yehualashet", "initials": "Y"}, {"family": "Muguni", "given": "Bongai", "initials": "B"}, {"family": "Najera", "given": "Hector", "initials": "H"}, {"family": "Nandy", "given": "Shailen", "initials": "S"}, {"family": "Heymann", "given": "S Jody", "initials": "SJ"}], "type": "journal article", "published": "2021-07-23", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": "149", "pages": "e183", "issn-l": null}, "abstract": "The feasibility of non-pharmacological public health interventions (NPIs) such as physical distancing or isolation at home to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in low-resource countries is unknown. Household survey data from 54 African countries were used to investigate the feasibility of SARS-CoV-2 NPIs in low-resource settings. Across the 54 countries, approximately 718 million people lived in households with \u2a7e6 individuals at home (median percentage of at-risk households 56% (95% confidence interval (CI), 51% to 60%)). Approximately 283 million people lived in households where \u2a7e3 people slept in a single room (median percentage of at-risk households 15% (95% CI, 13% to 19%)). An estimated 890 million Africans lack on-site water (71% (95% CI, 62% to 80%)), while 700 million people lacked in-home soap/washing facilities (56% (95% CI, 42% to 73%)). The median percentage of people without a refrigerator in the home was 79% (95% CI, 67% to 88%), while 45% (95% CI, 39% to 52%) shared toilet facilities with other households. Individuals in low-resource settings have substantial obstacles to implementing NPIs for mitigating SARS-CoV-2 transmission. These populations urgently need to be prioritised for coronavirus disease 2019 vaccination to prevent disease and to contain the global pandemic.", "doi": "10.1017/S0950268821001734", "pmid": "35852445", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0950268821001734"}, {"db": "pmc", "key": "PMC8367861"}], "notes": [], "created": "2022-08-12T08:50:35.543Z", "modified": "2022-08-12T08:51:09.009Z"}, {"entity": "publication", "iuid": "1bab0821eb174292b14bebc89e264da4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1bab0821eb174292b14bebc89e264da4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1bab0821eb174292b14bebc89e264da4"}}, "title": "Hofbauer cells and coronavirus disease 2019 (COVID-19) in pregnancy: Molecular pathology analysis of villous macrophages, endothelial cells, and placental findings from 22 placentas infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with and without fetal transmission.", "authors": [{"family": "Schwartz", "given": "David A", "initials": "DA"}, {"family": "Baldewijns", "given": "Marcella", "initials": "M"}, {"family": "Benachi", "given": "Alexandra", "initials": "A"}, {"family": "Bugatti", "given": "Mattia", "initials": "M"}, {"family": "Bulfamante", "given": "Gaetano", "initials": "G"}, {"family": "Cheng", "given": "Ke", "initials": "K"}, {"family": "Collins", "given": "Rebecca R J", "initials": "RRJ"}, {"family": "Debelenko", "given": "Larisa", "initials": "L"}, {"family": "De Luca", "given": "Dani\u00e8le", "initials": "D"}, {"family": "Facchetti", "given": "Fabio", "initials": "F"}, {"family": "Fitzgerald", "given": "Brendan", "initials": "B"}, {"family": "Levitan", "given": "Daniel", "initials": "D"}, {"family": "Linn", "given": "Rebecca L", "initials": "RL"}, {"family": "Marcelis", "given": "Lukas", "initials": "L"}, {"family": "Morotti", "given": "Denise", "initials": "D"}, {"family": "Morotti", "given": "Raffaella", "initials": "R"}, {"family": "Patan\u00e8", "given": "Luisa", "initials": "L"}, {"family": "Prevot", "given": "Sophie", "initials": "S"}, {"family": "Pulinx", "given": "Bianca", "initials": "B"}, {"family": "Saad", "given": "Ali G", "initials": "AG"}, {"family": "Schoenmakers", "given": "Sam", "initials": "S"}, {"family": "Strybol", "given": "David", "initials": "D"}, {"family": "Thomas", "given": "Kristen", "initials": "K"}, {"family": "Tosi", "given": "Delfina", "initials": "D"}, {"family": "Toto", "given": "Valentina", "initials": "V"}, {"family": "van der Meeren", "given": "Lotte E", "initials": "LE"}, {"family": "Verdijk", "given": "Robert M", "initials": "RM"}, {"family": "Vivanti", "given": "Alexandre J", "initials": "AJ"}, {"family": "Zaigham", "given": "Mehreen", "initials": "M"}], "type": "journal article", "published": "2021-07-23", "journal": {"title": "Arch Pathol Lab Med", "issn": "1543-2165", "issn-l": null}, "abstract": "- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can undergo maternal-fetal transmission, heightening interest in the placental pathology findings from this infection. Transplacental SARS-CoV-2 transmission is typically accompanied by chronic histiocytic intervillositis together with necrosis and positivity of syncytiotrophoblast for SARSCoV-2. Hofbauer cells are placental macrophages that have been involved in viral diseases including HIV and Zika virus, but their involvement in SARS-CoV-2 in unknown.\n\n- To determine whether SARS-CoV-2 can extend beyond the syncytiotrophoblast to enter Hofbauer cells, endothelium and other villous stromal cells in infected placentas of liveborn and stillborn infants.\n\n- Case-based retrospective analysis by 29 perinatal and molecular pathology specialists of placental findings from a preselected cohort of 22 SARS-CoV-2-infected placentas delivered to pregnant women testing positive for SARS-CoV-2 from 7 countries. Molecular pathology methods were used to investigate viral involvement of Hofbauer cells, villous capillary endothelium, syncytiotrophoblast and other fetal-derived cells.\n\n- Chronic histiocytic intervillositis and trophoblast necrosis was present in all 22 placentas (100%). SARS-CoV-2 was identified in Hofbauer cells from 4/22 placentas (18%). Villous capillary endothelial staining was positive in 2/22 cases (9%), both of which also had viral positivity in Hofbauer cells. Syncytiotrophoblast staining occurred in 21/22 placentas (95%). Hofbauer cell hyperplasia was present in 3/22 placentas (14%). In the 7 cases having documented transplacental infection of the fetus, 2 occurred in placentas with Hofbauer cell staining positive for SARS-CoV-2.\n\n- SARS-CoV-2 can extend beyond the trophoblast into the villous stroma, involving Hofbauer cells and capillary endothelial cells, in a small number of infected placentas. Most cases of SARS-CoV-2 transplacental fetal infection occur without Hofbauer cell involvement.", "doi": "10.5858/arpa.2021-0296-SA", "pmid": "34297794", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "468285"}], "notes": [], "created": "2021-08-05T07:09:11.883Z", "modified": "2021-08-05T07:09:11.909Z"}, {"entity": "publication", "iuid": "c38cd02818614d4db2930bfdc6e6e978", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c38cd02818614d4db2930bfdc6e6e978.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c38cd02818614d4db2930bfdc6e6e978"}}, "title": "COVID-19 in patients with CLL: improved survival outcomes and update on management strategies.", "authors": [{"family": "Roeker", "given": "Lindsey Elizabeth", "initials": "LE", "orcid": "0000-0002-3806-059X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d78144759e5240fda88869040bbb3405.json"}}, {"family": "Eyre", "given": "Toby Andrew", "initials": "TA", "orcid": "0000-0002-6631-9749", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d824fbb04d640d1b07bd88c1a09051c.json"}}, {"family": "Thompson", "given": "Meghan C", "initials": "MC"}, {"family": "Lamanna", "given": "Nicole", "initials": "N"}, {"family": "Coltoff", "given": "Alexander", "initials": "A"}, {"family": "Davids", "given": "Matthew S", "initials": "MS"}, {"family": "Baker", "given": "Peter", "initials": "P"}, {"family": "Leslie", "given": "Lori A", "initials": "LA"}, {"family": "Rogers", "given": "Kerry A", "initials": "KA", "orcid": "0000-0001-5748-7874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7dca0a2b81624be29144cc75eee2fe3f.json"}}, {"family": "Allan", "given": "John N", "initials": "JN", "orcid": "0000-0002-2088-0899", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f6a405964541f09452612c83538d89.json"}}, {"family": "Cordoba", "given": "Raul", "initials": "R", "orcid": "0000-0002-7654-8836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14e78d427a5a42c4aa2f063439846f7b.json"}}, {"family": "Lopez-Garcia", "given": "Alberto", "initials": "A", "orcid": "0000-0002-5354-5261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c785356a67e4cbb9835fe9ce04a6153.json"}}, {"family": "Antic", "given": "Darko", "initials": "D"}, {"family": "Pagel", "given": "John M", "initials": "JM"}, {"family": "Martinez-Calle", "given": "Nicol\u00e1s", "initials": "N", "orcid": "0000-0002-5184-9464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65797f47ca614ab88d8a11ec1ccf7207.json"}}, {"family": "Garcia-Marco", "given": "Jose Antonio", "initials": "JA", "orcid": "0000-0002-8993-5982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae24000421684dd4b672a42c0175db23.json"}}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jos\u00e9-\u00c1ngel", "initials": "J\u00c1", "orcid": "0000-0003-4550-757X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d071af0c0a14dc695bcda29033b49ce.json"}}, {"family": "Miras", "given": "Fatima", "initials": "F", "orcid": "0000-0001-5096-3145", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d86c6b42a4aa432195768fca2c6aa250.json"}}, {"family": "Coombs", "given": "Catherine C", "initials": "CC"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Seddon", "given": "Amanda N", "initials": "AN"}, {"family": "L\u00f3pez-Jim\u00e9nez", "given": "Javier", "initials": "J", "orcid": "0000-0002-2969-3002", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49c7283585d74f94898db807e53654db.json"}}, {"family": "Wilson", "given": "Matthew R", "initials": "MR", "orcid": "0000-0001-5423-3270", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc62369e0fb6429f94baf3619752c379.json"}}, {"family": "El-Sharkawi", "given": "Dima", "initials": "D", "orcid": "0000-0002-2752-5814", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fedd8b1cbb8c4e7a8a4a1840484d1289.json"}}, {"family": "Wojenski", "given": "Daniel", "initials": "D"}, {"family": "Ma", "given": "Shuo", "initials": "S"}, {"family": "Munir", "given": "Talha", "initials": "T"}, {"family": "Valenciano", "given": "Susana", "initials": "S"}, {"family": "Seymour", "given": "Erlene", "initials": "E"}, {"family": "Barr", "given": "Paul M", "initials": "PM", "orcid": "0000-0002-9733-401X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0ab119d82bf451db7cf78e7869c7ceb.json"}}, {"family": "Pu", "given": "Jeffrey J", "initials": "JJ", "orcid": "0000-0001-7498-3159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46d92e703b1e4634893c554254312a3f.json"}}, {"family": "Patten", "given": "Piers Em", "initials": "PE", "orcid": "0000-0003-3320-3034", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/245eaf4074b640499338cdf50ba61346.json"}}, {"family": "Perini", "given": "Guilherme Fleury", "initials": "GF"}, {"family": "Huntington", "given": "Scott F", "initials": "SF", "orcid": "0000-0001-7071-6475", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f9ee32a2ca0408697f8d8c1dfb185d8.json"}}, {"family": "Parry", "given": "Helen", "initials": "H", "orcid": "0000-0002-9707-8167", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5e7db11dc49496cac185fa8f9c99927.json"}}, {"family": "Sundaram", "given": "Suchitra", "initials": "S"}, {"family": "Skarbnik", "given": "Alan P", "initials": "AP"}, {"family": "Kamdar", "given": "Manali", "initials": "M"}, {"family": "Jacobs", "given": "Ryan W", "initials": "RW"}, {"family": "Walter", "given": "Harriet Sarah", "initials": "HS", "orcid": "0000-0003-2618-711X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76bd37449eda49b28de194fe74e9f289.json"}}, {"family": "Walewska", "given": "Renata", "initials": "R"}, {"family": "Broom", "given": "Angus", "initials": "A"}, {"family": "Lebowitz", "given": "Sonia", "initials": "S"}, {"family": "Isaac", "given": "Krista", "initials": "K", "orcid": "0000-0002-0234-139X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f2b9b13aac204070b5d7f7c3f69c123a.json"}}, {"family": "Portell", "given": "Craig A", "initials": "CA"}, {"family": "Ahn", "given": "Inhye E", "initials": "IE"}, {"family": "Ujjani", "given": "Chaitra", "initials": "C"}, {"family": "Shadman", "given": "Mazyar", "initials": "M", "orcid": "0000-0002-3365-6562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7856504963b74fbd85d7a62929233ed4.json"}}, {"family": "Sk\u00e5nland", "given": "Sigrid S", "initials": "SS"}, {"family": "Chong", "given": "Elise A", "initials": "EA"}, {"family": "Mato", "given": "Anthony R", "initials": "AR"}], "type": "journal article", "published": "2021-07-23", "journal": {"title": "Blood", "issn": "1528-0020", "issn-l": null}, "abstract": null, "doi": "10.1182/blood.2021011841", "pmid": "34297826", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "476453"}, {"db": "pmc", "key": "PMC8313815"}], "notes": [], "created": "2021-08-05T07:08:33.175Z", "modified": "2021-08-05T07:10:37.957Z"}, {"entity": "publication", "iuid": "3eb160a2384b417f8944066124b7e76b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3eb160a2384b417f8944066124b7e76b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3eb160a2384b417f8944066124b7e76b"}}, "title": "Anxiety, Compassion and Pride. How Emotions Elicited by the Government's Handling of Covid-19 Influences Health-Promoting Behavior.", "authors": [{"family": "Renstr\u00f6m", "given": "Emma A", "initials": "EA", "orcid": "0000-0001-6593-2464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c969b46ee25b4276916587537076440c.json"}}, {"family": "B\u00e4ck", "given": "Hanna", "initials": "H", "orcid": "0000-0002-0296-9419", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8afb5218cb145e99b138ef5b8d29f76.json"}}], "type": "journal article", "published": "2021-07-23", "journal": {"title": "Psychol Belg", "issn": "2054-670X", "volume": "61", "issue": "1", "pages": "224-237", "issn-l": null}, "abstract": "This article explores how emotions connected to the Government's handling of the Covid-19 outbreak in Sweden relates to behaviors to stop the spread of the virus, and which emotions functions as mediators in this relationship. The Swedish approach to handling the outbreak greatly differed from how many other Western European countries handled the situation and thus makes an important case to study. In a large representative survey (N = 2449), we found that satisfaction with how the Government handled the situation was related to more positive and less negative emotions. Anxiety, compassion and pride mediated the effect of satisfaction on compliance with the national recommendations such that anxiety and compassion increased compliance, while pride decreased it. Importantly though, satisfaction increased compassion and pride, but only compassion led to more compliant behaviors. In fact, satisfaction was indirectly related to less compliant behaviors via anxiety and pride. Shame mediated the effect on the tendency to wear face masks, a behavior that was explicitly not endorsed by the Swedish Public Health Agency. We speculate if the face mask, which was intensely debated, became a politicized symbol of dissatisfaction with the Swedish approach. In sum, it seems that individuals who were dissatisfied with how the government handled the Covid-19 outbreak were in fact engaging more in health-promotional behaviors to stop the spread of the virus.", "doi": "10.5334/pb.1053", "pmid": "34394949", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8300590"}], "notes": [], "created": "2021-08-17T06:43:53.775Z", "modified": "2021-08-17T06:43:53.850Z"}, {"entity": "publication", "iuid": "3023575e9ca747a4b7cb37e51b78464c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3023575e9ca747a4b7cb37e51b78464c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3023575e9ca747a4b7cb37e51b78464c"}}, "title": "Post-SARS-CoV-2-vaccination cerebral venous sinus thrombosis: an analysis of cases notified to the European Medicines Agency.", "authors": [{"family": "Krzywicka", "given": "Katarzyna", "initials": "K"}, {"family": "Heldner", "given": "Mirjam R", "initials": "MR", "orcid": "0000-0002-3594-2159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8280f8c6ea3a486abae8acc6aa491985.json"}}, {"family": "S\u00e1nchez van Kammen", "given": "Mayte", "initials": "M"}, {"family": "van Haaps", "given": "Thijs", "initials": "T"}, {"family": "Hiltunen", "given": "Sini", "initials": "S"}, {"family": "Silvis", "given": "Suzanne M", "initials": "SM"}, {"family": "Levi", "given": "Marcel", "initials": "M", "orcid": "0000-0002-2212-5299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d684119a7b2a42309d674f7094b81adc.json"}}, {"family": "Kremer Hovinga", "given": "Johanna A", "initials": "JA"}, {"family": "Jood", "given": "Katarina", "initials": "K"}, {"family": "Lindgren", "given": "Erik", "initials": "E"}, {"family": "Tatlisumak", "given": "Turgut", "initials": "T", "orcid": "0000-0002-2430-8988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03cddf3042b8470eaa083b6fa1e9e4bb.json"}}, {"family": "Putaala", "given": "Jukka", "initials": "J"}, {"family": "Aguiar de Sousa", "given": "Diana", "initials": "D", "orcid": "0000-0002-6702-7924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cc3515119a247859fe1fea025f703ef.json"}}, {"family": "Middeldorp", "given": "Saskia", "initials": "S", "orcid": "0000-0002-1006-6420", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03eef1eda4d0467084c5b8459e705cae.json"}}, {"family": "Arnold", "given": "Marcel", "initials": "M", "orcid": "0000-0002-4274-4644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10447e916b9b49f294e79a590139b9e3.json"}}, {"family": "Coutinho", "given": "Jonathan M", "initials": "JM", "orcid": "0000-0002-8284-982X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98cadafdcc044688bab25a3d7f9562b9.json"}}, {"family": "Ferro", "given": "Jos\u00e9 M", "initials": "JM", "orcid": "0000-0002-2343-9097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c8285bcf71c4ed1aa7b57a13c5cb70a.json"}}], "type": "journal article", "published": "2021-07-22", "journal": {"title": "Eur J Neurol", "issn": "1468-1331", "issn-l": null}, "abstract": "Cerebral venous sinus thrombosis (CVST) has been described after vaccination against SARS-CoV-2. The clinical characteristics of 213 post-vaccination CVST cases notified to the European Medicines Agency are reported.\n\nData on adverse drug reactions after SARS-CoV-2 vaccination notified until 8 April 2021 under the Medical Dictionary for Regulatory Activities Term 'Central nervous system vascular disorders' were obtained from the EudraVigilance database. Post-vaccination CVST was compared with 100 European patients with CVST from before the COVID-19 pandemic derived from the International CVST Consortium.\n\nIn all, 213 CVST cases were identified: 187 after AstraZeneca/Oxford (ChAdOx1 nCov-19) vaccination and 26 after a messenger RNA (mRNA) vaccination (25 with Pfizer/BioNTech, BNT162b2, and one with Moderna, mRNA-1273). Thrombocytopenia was reported in 107/187 CVST cases (57%, 95% confidence interval [CI] 50%-64%) in the ChAdOx1 nCov-19 group, in none in the mRNA vaccine group (0%, 95% CI 0%-13%) and in 7/100 (7%, 95% CI 3%-14%) in the pre-COVID-19 group. In the ChAdOx1 nCov-19 group, 39 (21%) reported COVID-19 polymerase chain reaction tests were performed within 30 days of CVST symptom onset, and all were negative. Of the 117 patients with a reported outcome in the ChAdOx1 nCov-19 group, 44 (38%, 95% CI 29%-47%) had died, compared to 2/10 (20%, 95% CI 6%-51%) in the mRNA vaccine group and 3/100 (3%, 95% CI 1%-8%) in the pre-COVID-19 group. Mortality amongst patients with thrombocytopenia in the ChAdOx1 nCov-19 group was 49% (95% CI 39%-60%).\n\nCerebral venous sinus thrombosis occurring after ChAdOx1 nCov-19 vaccination has a clinical profile distinct from CVST unrelated to vaccination. Only CVST after ChAdOx1 nCov-19 vaccination was associated with thrombocytopenia.", "doi": "10.1111/ene.15029", "pmid": "34293217", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-08-05T11:08:35.032Z", "modified": "2021-08-05T11:09:14.447Z"}, {"entity": "publication", "iuid": "c43b6b0e6a3b47f38b572fff9c87d349", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c43b6b0e6a3b47f38b572fff9c87d349.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c43b6b0e6a3b47f38b572fff9c87d349"}}, "title": "Physical activity and the risk of SARS-CoV-2 infection, severe COVID-19 illness and COVID-19 related mortality in South Korea: a nationwide cohort study.", "authors": [{"family": "Lee", "given": "Seung Won", "initials": "SW", "orcid": "0000-0001-5632-5208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b38b67e00dbf4d80a72a30152b99c0a3.json"}}, {"family": "Lee", "given": "Jinhee", "initials": "J"}, {"family": "Moon", "given": "Sung Yong", "initials": "SY"}, {"family": "Jin", "given": "Hyun Young", "initials": "HY"}, {"family": "Yang", "given": "Jee Myung", "initials": "JM"}, {"family": "Ogino", "given": "Shuji", "initials": "S"}, {"family": "Song", "given": "Mingyang", "initials": "M"}, {"family": "Hong", "given": "Sung Hwi", "initials": "SH"}, {"family": "Abou Ghayda", "given": "Ramy", "initials": "R"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Jacob", "given": "Louis", "initials": "L"}, {"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Smith", "given": "Lee", "initials": "L"}, {"family": "Giovannucci", "given": "Edward", "initials": "E"}, {"family": "Lee", "given": "I-Min", "initials": "IM", "orcid": "0000-0002-1083-6907", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d9a901889fd4ddabefdbab40fbaf1ae.json"}}, {"family": "Lee", "given": "Dong Hoon", "initials": "DH"}, {"family": "Lee", "given": "Keum Hwa", "initials": "KH"}, {"family": "Shin", "given": "Youn Ho", "initials": "YH"}, {"family": "Kim", "given": "So Young", "initials": "SY"}, {"family": "Kim", "given": "Min Seo", "initials": "MS", "orcid": "0000-0003-2115-7835", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3078a38bd45044b3ac5b32d0eb09fbda.json"}}, {"family": "Won", "given": "Hong-Hee", "initials": "HH"}, {"family": "Ekelund", "given": "Ulf", "initials": "U"}, {"family": "Shin", "given": "Jae Il", "initials": "JI"}, {"family": "Yon", "given": "Dong Keon", "initials": "DK", "orcid": "0000-0003-1628-9948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/747eb5856d2e444fbc1e5aaef8d3aa40.json"}}], "type": "journal article", "published": "2021-07-22", "journal": {"title": "Br J Sports Med", "issn": "1473-0480", "issn-l": null}, "abstract": "To determine the potential associations between physical activity and risk of SARS-CoV-2 infection, severe illness from COVID-19 and COVID-19 related death using a nationwide cohort from South Korea.\n\nData regarding 212 768 Korean adults (age \u226520 years), who tested for SARS-CoV-2, from 1 January 2020 to 30 May 2020, were obtained from the National Health Insurance Service of South Korea and further linked with the national general health examination from 1 January 2018 to 31 December 2019 to assess physical activity levels. SARS-CoV-2 positivity, severe COVID-19 illness and COVID-19 related death were the main outcomes. The observation period was between 1 January 2020 and 31 July 2020.\n\nOut of 76 395 participants who completed the general health examination and were tested for SARS-CoV-2, 2295 (3.0%) were positive for SARS-CoV-2, 446 (0.58%) had severe illness from COVID-19 and 45 (0.059%) died from COVID-19. Adults who engaged in both aerobic and muscle strengthening activities according to the 2018 physical activity guidelines had a lower risk of SARS-CoV-2 infection (2.6% vs 3.1%; adjusted relative risk (aRR), 0.85; 95% CI 0.72 to 0.96), severe COVID-19 illness (0.35% vs 0.66%; aRR 0.42; 95% CI 0.19 to 0.91) and COVID-19 related death (0.02% vs 0.08%; aRR 0.24; 95% CI 0.05 to 0.99) than those who engaged in insufficient aerobic and muscle strengthening activities. Furthermore, the recommended range of metabolic equivalent task (MET; 500-1000 MET min/week) was associated with the maximum beneficial effect size for reduced risk of SARS-CoV-2 infection (aRR 0.78; 95% CI 0.66 to 0.92), severe COVID-19 illness (aRR 0.62; 95% CI 0.43 to 0.90) and COVID-19 related death (aRR 0.17; 95% CI 0.07 to 0.98). Similar patterns of association were observed in different sensitivity analyses.\n\nAdults who engaged in the recommended levels of physical activity were associated with a decreased likelihood of SARS-CoV-2 infection, severe COVID-19 illness and COVID-19 related death. Our findings suggest that engaging in physical activity has substantial public health value and demonstrates potential benefits to combat COVID-19.", "doi": "10.1136/bjsports-2021-104203", "pmid": "34301715", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bjsports-2021-104203"}, {"db": "pmc", "key": "PMC8300550"}], "notes": [], "created": "2021-08-05T07:06:44.215Z", "modified": "2021-08-05T07:06:45.565Z"}, {"entity": "publication", "iuid": "1a006b8339e64c42b03e1e4d6206b370", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1a006b8339e64c42b03e1e4d6206b370.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1a006b8339e64c42b03e1e4d6206b370"}}, "title": "Marine Sulfated Polysaccharides as Promising Antiviral Agents: A Comprehensive Report and Modeling Study Focusing on SARS CoV-2.", "authors": [{"family": "Salih", "given": "Abdalla E M", "initials": "AEM"}, {"family": "Thissera", "given": "Bathini", "initials": "B", "orcid": "0000-0002-0998-4187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b46765518df488e9f7433b162103dde.json"}}, {"family": "Yaseen", "given": "Mohammed", "initials": "M", "orcid": "0000-0002-2460-1893", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b57b297419fe47188812beeaffc62cf0.json"}}, {"family": "Hassane", "given": "Ahmed S I", "initials": "ASI"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}, {"family": "Sayed", "given": "Ahmed M", "initials": "AM", "orcid": "0000-0002-1442-183X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/013ee0ba73bb4d7f87fd285c65e49725.json"}}, {"family": "Rateb", "given": "Mostafa E", "initials": "ME", "orcid": "0000-0003-4043-2687", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59c7eb5f74ca45f695bffb7960cbedcc.json"}}], "type": "journal article", "published": "2021-07-22", "journal": {"title": "Mar Drugs", "issn": "1660-3397", "volume": "19", "issue": "8", "pages": "406", "issn-l": null}, "abstract": "SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) is a novel coronavirus strain that emerged at the end of 2019, causing millions of deaths so far. Despite enormous efforts being made through various drug discovery campaigns, there is still a desperate need for treatments with high efficacy and selectivity. Recently, marine sulfated polysaccharides (MSPs) have earned significant attention and are widely examined against many viral infections. This article attempted to produce a comprehensive report about MSPs from different marine sources alongside their antiviral effects against various viral species covering the last 25 years of research articles. Additionally, these reported MSPs were subjected to molecular docking and dynamic simulation experiments to ascertain potential interactions with both the receptor-binding domain (RBD) of SARS CoV-2's spike protein (S-protein) and human angiotensin-converting enzyme-2 (ACE2). The possible binding sites on both S-protein's RBD and ACE2 were determined based on how they bind to heparin, which has been reported to exhibit significant antiviral activity against SARS CoV-2 through binding to RBD, preventing the virus from affecting ACE2. Moreover, our modeling results illustrate that heparin can also bind to and block ACE2, acting as a competitor and protective agent against SARS CoV-2 infection. Nine of the investigated MSPs candidates exhibited promising results, taking into consideration the newly emerged SARS CoV-2 variants, of which five were not previously reported to exert antiviral activity against SARS CoV-2, including sulfated galactofucan (1), sulfated polymannuroguluronate (SPMG) (2), sulfated mannan (3), sulfated heterorhamnan (8), and chondroitin sulfate E (CS-E) (9). These results shed light on the importance of sulfated polysaccharides as potential SARS-CoV-2 inhibitors.", "doi": "10.3390/md19080406", "pmid": "34436245", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "md19080406"}, {"db": "pmc", "key": "PMC8401819"}], "notes": [], "created": "2021-08-27T09:35:33.179Z", "modified": "2021-09-01T07:17:08.967Z"}, {"entity": "publication", "iuid": "5f137f6991f648d0876bfdbe5a44aab0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f137f6991f648d0876bfdbe5a44aab0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f137f6991f648d0876bfdbe5a44aab0"}}, "title": "Ultrametric diffusion equation on energy landscape to model disease spread in hierarchic socially clustered population.", "authors": [{"family": "Khrennikov", "given": "Andrei", "initials": "A"}], "type": "journal article", "published": "2021-07-21", "journal": {"title": "Physica A", "issn": "0378-4371", "pages": "126284", "issn-l": null}, "abstract": "We present a new mathematical model of disease spread reflecting some specialties of the covid-19 epidemic by elevating the role of hierarchic social clustering of population. The model can be used to explain slower approaching herd immunity, e.g., in Sweden, than it was predicted by a variety of other mathematical models and was expected by epidemiologists; see graphs Fig. 1,2. The hierarchic structure of social clusters is mathematically modeled with ultrametric spaces having treelike geometry. To simplify mathematics, we consider trees with the constant number of branches leaving each vertex. Such trees are endowed with an algebraic structure, these are p > 1 -adic number fields. We apply theory of the p -adic diffusion equation to describe a virus spread in hierarchically clustered population. This equation has applications to statistical physics and microbiology for modeling pdynamics on energy landscapes. To move from one social cluster (valley) to another, a virus (its carrier) should cross a social barrier between them. The magnitude of a barrier depends on the number of social hierarchy's levels composing this barrier. We consider linearly increasing barriers. A virus spreads rather easily inside a social cluster (say working collective), but jumps to other clusters are constrained by social barriers. This behavior matches with the covid-19 epidemic, with its cluster spreading structure. Our model differs crucially from the standard mathematical models of spread of disease, such as the SIR-model; in particular, by notion of the probability to be infected (at time in a social cluster t ). We present socio-medical specialties of the covid-19 epidemic supporting our model.C", "doi": "10.1016/j.physa.2021.126284", "pmid": "34312573", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0378-4371(21)00557-4"}, {"db": "pmc", "key": "PMC8294751"}], "notes": [], "created": "2021-08-05T06:50:47.154Z", "modified": "2021-08-05T06:50:47.181Z"}, {"entity": "publication", "iuid": "ee384aaba0c94162879c0d22e3f0f263", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee384aaba0c94162879c0d22e3f0f263.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee384aaba0c94162879c0d22e3f0f263"}}, "title": "Impact of the COVID-19 pandemic on the management of chronic noninfectious respiratory diseases.", "authors": [{"family": "Tiotiu", "given": "Angelica", "initials": "A", "orcid": "0000-0002-8038-9559", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ee2c77aeb734a9dbb4746210468f2d5.json"}}, {"family": "Chong Neto", "given": "Herberto", "initials": "H"}, {"family": "Bikov", "given": "Andras", "initials": "A"}, {"family": "Kowal", "given": "Krzysztof", "initials": "K"}, {"family": "Steiropoulos", "given": "Paschalis", "initials": "P"}, {"family": "Labor", "given": "Marina", "initials": "M", "orcid": "0000-0001-5216-8129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9a750b29a224b7bb07d535004dfdf15.json"}}, {"family": "Cherrez-Ojeda", "given": "Ivan", "initials": "I", "orcid": "0000-0002-1610-239X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ee022e7bd4d4b80baa3c24aa98c0b92.json"}}, {"family": "Badellino", "given": "Hector", "initials": "H"}, {"family": "Emelyanov", "given": "Alexander", "initials": "A"}, {"family": "Garcia", "given": "Rocio", "initials": "R"}, {"family": "Guidos", "given": "Guillermo", "initials": "G", "orcid": "0000-0003-1675-3894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9446a00028a248e49be76f868ee7c701.json"}}], "type": "journal article", "published": "2021-07-21", "journal": {"title": "Expert Rev Respir Med", "issn": "1747-6356", "pages": "1-14", "issn-l": null}, "abstract": "Introduction: The COVID-19 pandemic has challenged health care across the world, not just by the severity of the disease and the high mortality rate but also by the consequences on the management of the patients with chronic diseases.Areas covered: This review summarizes the most up-to-date published data regarding the impact of COVID-19 on the management and outcomes of patients with chronic noninfectious respiratory illnesses including obstructive sleep apnea, asthma, chronic obstructive pulmonary disease, bronchiectasis, interstitial and pulmonary vascular diseases, and lung cancer.Expert opinion: Most of chronic respiratory diseases (except asthma and cystic fibrosis) are associated with more severe COVID-19 and poor outcomes but the mechanisms involved are not yet identified. The therapeutic management of the patients with chronic respiratory diseases and COVID-19 is similar to the other patients but the post-recovery course could be worse in this population and followed by the development of pulmonary fibrosis, bronchiectasis, and pulmonary hypertension. The pandemic highly impacted our usual medical activities by limiting the access to several diagnosis procedures, the necessity to develop new methods for the monitoring of the disease and adapt the therapeutic strategies. The long-term consequences of all these changes are still unknown.", "doi": "10.1080/17476348.2021.1951707", "pmid": "34253132", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:35:18.427Z", "modified": "2021-08-06T07:35:30.520Z"}, {"entity": "publication", "iuid": "dde1dda8dae541878726006521406dfd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dde1dda8dae541878726006521406dfd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dde1dda8dae541878726006521406dfd"}}, "title": "Dapagliflozin in patients with cardiometabolic risk factors hospitalised with COVID-19 (DARE-19): a randomised, double-blind, placebo-controlled, phase 3 trial.", "authors": [{"family": "Kosiborod", "given": "Mikhail N", "initials": "MN"}, {"family": "Esterline", "given": "Russell", "initials": "R"}, {"family": "Furtado", "given": "Remo H M", "initials": "RHM"}, {"family": "Oscarsson", "given": "Jan", "initials": "J"}, {"family": "Gasparyan", "given": "Samvel B", "initials": "SB"}, {"family": "Koch", "given": "Gary G", "initials": "GG"}, {"family": "Martinez", "given": "Felipe", "initials": "F"}, {"family": "Mukhtar", "given": "Omar", "initials": "O"}, {"family": "Verma", "given": "Subodh", "initials": "S"}, {"family": "Chopra", "given": "Vijay", "initials": "V"}, {"family": "Buenconsejo", "given": "Joan", "initials": "J"}, {"family": "Langkilde", "given": "Anna Maria", "initials": "AM"}, {"family": "Ambery", "given": "Philip", "initials": "P"}, {"family": "Tang", "given": "Fengming", "initials": "F"}, {"family": "Gosch", "given": "Kensey", "initials": "K"}, {"family": "Windsor", "given": "Sheryl L", "initials": "SL"}, {"family": "Akin", "given": "Emily E", "initials": "EE"}, {"family": "Soares", "given": "Ronaldo V P", "initials": "RVP"}, {"family": "Moia", "given": "Diogo D F", "initials": "DDF"}, {"family": "Aboudara", "given": "Matthew", "initials": "M"}, {"family": "Hoffmann Filho", "given": "Conrado Roberto", "initials": "CR"}, {"family": "Feitosa", "given": "Audes D M", "initials": "ADM"}, {"family": "Fonseca", "given": "Alberto", "initials": "A"}, {"family": "Garla", "given": "Vishnu", "initials": "V"}, {"family": "Gordon", "given": "Robert A", "initials": "RA"}, {"family": "Javaheri", "given": "Ali", "initials": "A"}, {"family": "Jaeger", "given": "Cristiano P", "initials": "CP"}, {"family": "Leaes", "given": "Paulo E", "initials": "PE"}, {"family": "Nassif", "given": "Michael", "initials": "M"}, {"family": "Pursley", "given": "Michael", "initials": "M"}, {"family": "Silveira", "given": "Fabio Serra", "initials": "FS"}, {"family": "Barroso", "given": "Weimar Kunz Sebba", "initials": "WKS"}, {"family": "Lazcano Soto", "given": "Jos\u00e9 Roberto", "initials": "JR"}, {"family": "Nigro Maia", "given": "Lilia", "initials": "L"}, {"family": "Berwanger", "given": "Otavio", "initials": "O"}], "type": "journal article", "published": "2021-07-21", "journal": {"title": "Lancet Diabetes Endocrinol", "issn": "2213-8595", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "COVID-19 can lead to multiorgan failure. Dapagliflozin, a SGLT2 inhibitor, has significant protective benefits for the heart and kidney. We aimed to see whether this agent might provide organ protection in patients with COVID-19 by affecting processes dysregulated during acute illness.\r\n\r\nDARE-19 was a randomised, double-blind, placebo-controlled trial of patients hospitalised with COVID-19 and with at least one cardiometabolic risk factor (ie, hypertension, type 2 diabetes, atherosclerotic cardiovascular disease, heart failure, and chronic kidney disease). Patients critically ill at screening were excluded. Patients were randomly assigned 1:1 to dapagliflozin (10 mg daily orally) or matched placebo for 30 days. Dual primary outcomes were assessed in the intention-to-treat population: the outcome of prevention (time to new or worsened organ dysfunction or death), and the hierarchial composite outcome of recovery (change in clinical status by day 30). Safety outcomes, in patients who received at least one study medication dose, included serious adverse events, adverse events leading to discontinuation, and adverse events of interest. This study is registered with ClinicalTrials.gov, NCT04350593.\r\n\r\nBetween April 22, 2020 and Jan 1, 2021, 1250 patients were randomly assigned with 625 in each group. The primary composite outcome of prevention showed organ dysfunction or death occurred in 70 patients (11\u00b72%) in the dapagliflozin group, and 86 (13\u00b78%) in the placebo group (hazard ratio [HR] 0\u00b780, 95% CI 0\u00b758-1\u00b710; p=0\u00b717). For the primary outcome of recovery, 547 patients (87\u00b75%) in the dapagliflozin group and 532 (85\u00b71%) in the placebo group showed clinical status improvement, although this was not statistically significant (win ratio 1\u00b709, 95% CI 0\u00b797-1\u00b722; p=0\u00b714). There were 41 deaths (6\u00b76%) in the dapagliflozin group, and 54 (8\u00b76%) in the placebo group (HR 0\u00b777, 95% CI 0\u00b752-1\u00b716). Serious adverse events were reported in 65 (10\u00b76%) of 613 patients treated with dapagliflozin and in 82 (13\u00b73%) of 616 patients given the placebo.\r\n\r\nIn patients with cardiometabolic risk factors who were hospitalised with COVID-19, treatment with dapagliflozin did not result in a statistically significant risk reduction in organ dysfunction or death, or improvement in clinical recovery, but was well tolerated.\r\n\r\nAstraZeneca.", "doi": "10.1016/S2213-8587(21)00180-7", "pmid": "34302745", "labels": {"Category: Biochemistry": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2213-8587(21)00180-7"}, {"db": "pmc", "key": "PMC8294807"}, {"db": "ClinicalTrials.gov", "key": "NCT04350593"}], "notes": [], "created": "2021-08-05T07:04:41.191Z", "modified": "2021-08-05T07:06:23.441Z"}, {"entity": "publication", "iuid": "f679a141107f4d0989dcf6a28593d307", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f679a141107f4d0989dcf6a28593d307.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f679a141107f4d0989dcf6a28593d307"}}, "title": "The role of psychological flexibility, perceived injustice and body image in Vulvodynia: A longitudinal study.", "authors": [{"family": "Chisari", "given": "Claudia", "initials": "C", "orcid": "0000-0002-1118-7443", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7db18ed16a6b4626a61233e39134480f.json"}}, {"family": "Budhraja", "given": "Mahira", "initials": "M", "orcid": "0000-0001-6211-1580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8157535613a1480ea74dba80561d0247.json"}}, {"family": "Monajemi", "given": "Mani B", "initials": "MB", "orcid": "0000-0002-9052-817X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bc7992e02a641258745fd8f24a7d922.json"}}, {"family": "Lewis", "given": "Fiona", "initials": "F", "orcid": "0000-0003-4267-1518", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/229a764990744509b093aafb03e20143.json"}}, {"family": "Moss-Morris", "given": "Rona", "initials": "R", "orcid": "0000-0002-2927-3446", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d47c00d0c4244b2858091fbf7bd0160.json"}}, {"family": "Scott", "given": "Whitney", "initials": "W", "orcid": "0000-0002-2529-9083", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e786db5451e41b99b48253784db8af8.json"}}, {"family": "McCracken", "given": "Lance M", "initials": "LM", "orcid": "0000-0002-9734-0153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e7520672ca04462b00b191b756a1b7a.json"}}], "type": "journal article", "published": "2021-07-20", "journal": {"title": "Eur J Pain", "issn": "1532-2149", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Women with Vulvodynia experience pain, related impacts on sex and daily functioning, and depression. While psychosocial factors are associated with outcomes in Vulvodynia, longitudinal data are limited, especially in mixed/spontaneous Vulvodynia. Broad psychological models such as psychological flexibility (PF) and content-specific factors, such as body-exposure anxiety (BEA) and avoidance during sexual activities and perceived injustice, have not been adequately investigated in Vulvodynia. The aim of this study was to explore whether these factors assessed at baseline predict pain severity, pain interference, sexual functioning and satisfaction and depression 3 months later.\r\n\r\nA longitudinal study of 349 women with Vulvodynia was conducted. Participants completed online self-report measures of pain-related and sexual outcomes, depression, BEA, perceived injustice and facets of PF (present moment awareness, pain acceptance, committed action) at baseline and after 3 months, overlapping with the Coronavirus disease 2019 (COVID-19) pandemic.\r\n\r\nSeventy percent of women responded at both assessments (n = 244). There were significant decreases in pain severity, pain interference, present moment awareness, committed action and a significant increase in depression at 3 months. All the baseline psychosocial factors significantly correlated with at least one outcome at 3 months. When adjusting for baseline outcome and demographics, committed action significantly positively predicted depression at 3 months and pain acceptance significantly positively predicted pain interference at 3 months.\r\n\r\nAmong women with Vulvodynia, pain acceptance and committed action are prospectively associated with pain interference and depression. The reliability and generalizability of these results needs to be established given the overlap with the COVID-19 pandemic. Future studies should investigate whether targeting these factors enhances outcomes in Vulvodynia.\r\n\r\nThis longitudinal study explored the role of PF, perceived injustice and body image during sexual activities in predicting pain severity, pain interference, sexual functioning, sexual satisfaction and depression in women with Vulvodynia. The study findings reveal that two facets of PF (committed action and pain acceptance) predicted pain interference and depression over time. It may be important to incorporate these processes in treatments developed for Vulvodynia.", "doi": "10.1002/ejp.1841", "pmid": "34288269", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-05T11:10:05.526Z", "modified": "2021-11-18T11:42:07.844Z"}, {"entity": "publication", "iuid": "3c1f7865c030414ba948b78279881d3b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3c1f7865c030414ba948b78279881d3b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3c1f7865c030414ba948b78279881d3b"}}, "title": "Self-reported neurocognitive symptoms during COVID-19 lockdown and its associated factors in a sample of psychiatric patients. Results from the BRIS-MHC study.", "authors": [{"family": "Montejo", "given": "Laura", "initials": "L"}, {"family": "Sol\u00e9", "given": "Brisa", "initials": "B"}, {"family": "Verdolini", "given": "Norma", "initials": "N"}, {"family": "Mart\u00ednez-Ar\u00e1n", "given": "Anabel", "initials": "A"}, {"family": "Bonn\u00edn", "given": "Caterina Del Mar", "initials": "CDM"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Mart\u00edn-Villalba", "given": "In\u00e9s", "initials": "I"}, {"family": "Williams", "given": "Evelin", "initials": "E"}, {"family": "Garc\u00eda-Rizo", "given": "Clemente", "initials": "C"}, {"family": "Mezquida", "given": "Gisela", "initials": "G"}, {"family": "Bernardo", "given": "Miguel", "initials": "M"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Torrent", "given": "Carla", "initials": "C"}, {"family": "Amoretti", "given": "Silvia", "initials": "S"}, {"family": "BRIS-MHC research group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-07-20", "journal": {"title": "Eur Neuropsychopharmacol", "issn": "1873-7862", "volume": "53", "pages": "7-18", "issn-l": null}, "abstract": "Lockdown caused by COVID-19 pandemic has a negative impact on mental health. The aim was to assess self-reported neurocognitive symptoms during the lockdown and identify associated vulnerable and protective factors in a sample of psychiatric patients in a Spanish population. These results are part of the Barcelona ResIlience Survey for Mental Health COVID-19 (BRIS-MHC) project. Neurocognitive symptoms were assessed through an online survey considering the five items that represented self-reported neurocognitive complaints. We split the sample into two groups based on the severity of the self-reported neurocognitive complaints: intact cognitive function/mild cognitive impairment (CI-) and moderate/severe cognitive impairment (CI+). Univariate analyses were used to compare both groups in terms of sociodemographic and clinical variables. Multiple logistic regression models were carried out to identify clinical variables and coping strategies associated with neurocognitive symptoms. 198 patients with different psychiatric diagnoses were included in this study. One hundred seventeen patients were classified in the CI- group and 81 in the CI+ group. Depressive symptoms and negative psychotic-like symptoms were vulnerable factors for neurocognitive impairment. Coping strategies of performing physical activity, carrying out relaxing activities and maintaining a routine were protective factors against cognitive impairment. Lockdown situation negatively impact on neurocognitive function. Psychopathological symptoms and coping strategies were associated with neurocognitive symptoms during lockdown in subjects with psychiatric illness. The early treatment of psychopathological symptoms in psychiatric patients and promoting coping strategies during lockdown should be considered an intervention strategy against cognitive impairment.", "doi": "10.1016/j.euroneuro.2021.07.006", "pmid": "34348213", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0924-977X(21)00275-3"}], "notes": [], "created": "2021-08-06T09:43:53.370Z", "modified": "2021-08-06T09:43:53.393Z"}, {"entity": "publication", "iuid": "a7b20101f22d4155888dae5620248fa0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7b20101f22d4155888dae5620248fa0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7b20101f22d4155888dae5620248fa0"}}, "title": "Excess all-cause mortality and COVID-19-related mortality: a temporal analysis in 22 countries, from January until August 2020.", "authors": [{"family": "Achilleos", "given": "Souzana", "initials": "S", "orcid": "0000-0002-1688-9225", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce5b51f054484805abea56ebad2bffc6.json"}}, {"family": "Quattrocchi", "given": "Annalisa", "initials": "A", "orcid": "0000-0002-5764-6721", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9a78ec6310743ec9b60a592a0ac61bd.json"}}, {"family": "Gabel", "given": "John", "initials": "J"}, {"family": "Heraclides", "given": "Alexandros", "initials": "A", "orcid": "0000-0002-1304-3275", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c763a75d0dc4841adfc2f0ea63abb3b.json"}}, {"family": "Kolokotroni", "given": "Ourania", "initials": "O", "orcid": "0000-0002-7653-002X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f695065afcc4c2a9dc89ac04506279b.json"}}, {"family": "Constantinou", "given": "Constantina", "initials": "C"}, {"family": "Pagola Ugarte", "given": "Maider", "initials": "M"}, {"family": "Nicolaou", "given": "Nicoletta", "initials": "N"}, {"family": "Rodriguez-Llanes", "given": "Jose Manuel", "initials": "JM"}, {"family": "Bennett", "given": "Catherine Marie", "initials": "CM"}, {"family": "Bogatyreva", "given": "Ekaterina", "initials": "E"}, {"family": "Schernhammer", "given": "Eva", "initials": "E", "orcid": "0000-0002-4337-9415", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ada7385c4ac4d168d76e00d8383133b.json"}}, {"family": "Zimmermann", "given": "Claudia", "initials": "C"}, {"family": "Costa", "given": "Antonio Jose Leal", "initials": "AJL"}, {"family": "Lobato", "given": "Jackeline Christiane Pinto", "initials": "JCP"}, {"family": "Fernandes", "given": "Ngibo Mubeta", "initials": "NM"}, {"family": "Semedo-Aguiar", "given": "Ana Paula", "initials": "AP"}, {"family": "Jaramillo Ramirez", "given": "Gloria Isabel", "initials": "GI"}, {"family": "Martin Garzon", "given": "Oscar Dario", "initials": "OD"}, {"family": "Mortensen", "given": "Laust Hvas", "initials": "LH"}, {"family": "Critchley", "given": "Julia A", "initials": "JA"}, {"family": "Goldsmith", "given": "Lucy P", "initials": "LP"}, {"family": "Denissov", "given": "Gleb", "initials": "G"}, {"family": "R\u00fc\u00fctel", "given": "Kristi", "initials": "K"}, {"family": "Le Meur", "given": "Nolwenn", "initials": "N", "orcid": "0000-0001-8451-4014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7ccd56127144ac4b7044dfaf98ca8e6.json"}}, {"family": "Kandelaki", "given": "Levan", "initials": "L"}, {"family": "Tsiklauri", "given": "Shorena", "initials": "S"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}, {"family": "Oza", "given": "Ajay", "initials": "A"}, {"family": "Kaufman", "given": "Zalman", "initials": "Z"}, {"family": "Zucker", "given": "Inbar", "initials": "I"}, {"family": "Ambrosio", "given": "Giuseppe", "initials": "G"}, {"family": "Stracci", "given": "Fabrizio", "initials": "F"}, {"family": "Hagen", "given": "Terje P", "initials": "TP"}, {"family": "Erzen", "given": "Ivan", "initials": "I"}, {"family": "Klepac", "given": "Petra", "initials": "P"}, {"family": "Arcos Gonz\u00e1lez", "given": "Pedro", "initials": "P"}, {"family": "Fern\u00e1ndez Camporro", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "Burstr\u00f6m", "given": "Bo", "initials": "B"}, {"family": "Pidmurniak", "given": "Nataliia", "initials": "N"}, {"family": "Verstiuk", "given": "Olesia", "initials": "O"}, {"family": "Huang", "given": "Qian", "initials": "Q"}, {"family": "Mehta", "given": "Neil Kishor", "initials": "NK"}, {"family": "Polemitis", "given": "Antonis", "initials": "A"}, {"family": "Charalambous", "given": "Andreas", "initials": "A"}, {"family": "Demetriou", "given": "Christiana A", "initials": "CA", "orcid": "0000-0003-4002-2880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00673897042047668d72abac855f4cc8.json"}}], "type": "journal article", "published": "2021-07-20", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "issn-l": "0300-5771"}, "abstract": "This study aimed to investigate overall and sex-specific excess all-cause mortality since the inception of the COVID-19 pandemic until August 2020 among 22 countries.\n\nCountries reported weekly or monthly all-cause mortality from January 2015 until the end of June or August 2020. Weekly or monthly COVID-19 deaths were reported for 2020. Excess mortality for 2020 was calculated by comparing weekly or monthly 2020 mortality (observed deaths) against a baseline mortality obtained from 2015-2019 data for the same week or month using two methods: (i) difference in observed mortality rates between 2020 and the 2015-2019 average and (ii) difference between observed and expected 2020 deaths.\n\nBrazil, France, Italy, Spain, Sweden, the UK (England, Wales, Northern Ireland and Scotland) and the USA demonstrated excess all-cause mortality, whereas Australia, Denmark and Georgia experienced a decrease in all-cause mortality. Israel, Ukraine and Ireland demonstrated sex-specific changes in all-cause mortality.\n\nAll-cause mortality up to August 2020 was higher than in previous years in some, but not all, participating countries. Geographical location and seasonality of each country, as well as the prompt application of high-stringency control measures, may explain the observed variability in mortality changes.", "doi": "10.1093/ije/dyab123", "pmid": "34282450", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6324094"}], "notes": [], "created": "2021-08-05T11:10:50.663Z", "modified": "2021-08-05T11:10:50.818Z"}, {"entity": "publication", "iuid": "5180e25d70e04467a74f2ece3c74865d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5180e25d70e04467a74f2ece3c74865d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5180e25d70e04467a74f2ece3c74865d"}}, "title": "Collective insights of public-private partnership impacts and sustainability: A qualitative analysis.", "authors": [{"family": "Strasser", "given": "Sheryl", "initials": "S", "orcid": "0000-0002-6813-7180", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8f19d212059447f80d8a0c0c6c2c341.json"}}, {"family": "Stauber", "given": "Christine", "initials": "C"}, {"family": "Shrivastava", "given": "Ritu", "initials": "R"}, {"family": "Riley", "given": "Patricia", "initials": "P", "orcid": "0000-0002-2901-5834", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5853c1026896400997d09c70f192819b.json"}}, {"family": "O'Quin", "given": "Karen", "initials": "K"}], "type": "journal article", "published": "2021-07-20", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "7", "pages": "e0254495"}, "abstract": "The global Coronavirus or COVID-19 pandemic exposed the weakness of healthcare systems including laboratory systems and is a call to action for unprecedented collaboration and partnerships to deal with the global crisis. The United States (U.S.) President's Emergency Plan for AIDS Relief (PEPFAR) establishes the global HIV/AIDS treatment agenda in alignment with the UNAIDS 90-90-90 treatment targets to achieve epidemic control related to enhanced testing, treatment, and viral suppression. A strategic PEPFAR priority area recognizes that large-scale collective efforts and sharing of resources bear greater potential impact for lasting change than any single organization or entity can achieve alone. An important vehicle utilized within the global public health context is the public-private partnership (PPP) model whereby multiple international organizations forge unified project charters to collectively reach mutually agreed goals. While touted as an ideal mechanism to synthesize resources and maximize gain in numerous applications, little is known from a seasoned stakeholder perspective regarding PPP implementation and sustainability issues. The purpose of this research is to holistically examine perceptions of PPP model sustainability related to inputs and impacts among a collective network of stakeholders experienced with PEPFAR workforce development, laboratory-system strengthening project implementation. Interviews were conducted with frontline stakeholders from public and private sector organizations based in the US and select PEPFAR-supported priority countries. Analysis revealed three dominant themes: PPP impacts, keys of successful collaboration, and logistical challenges and opportunities to enhance sustainability of PPP outcomes in the future.", "doi": "10.1371/journal.pone.0254495", "pmid": "34283847", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-32179"}, {"db": "pmc", "key": "PMC8291689"}], "notes": [], "created": "2021-08-05T11:10:28.875Z", "modified": "2021-11-18T09:37:43.715Z"}, {"entity": "publication", "iuid": "4dbd1bbcf14f4041ade0b1493564840e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4dbd1bbcf14f4041ade0b1493564840e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4dbd1bbcf14f4041ade0b1493564840e"}}, "title": "Assessment of Ventilation and Perfusion in Patients with COVID-19 Discloses Unique Information of Pulmonary Function to a Clinician: Case Reports of V/P SPECT.", "authors": [{"family": "Bajc", "given": "Marika", "initials": "M"}, {"family": "Hedeer", "given": "Fredrik", "initials": "F"}, {"family": "Lindqvist", "given": "Ari", "initials": "A", "orcid": "0000-0002-0062-0117", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1ce81ade04c476facbbdd9ddea80939.json"}}, {"family": "Tr\u00e4g\u00e5rdh", "given": "Elin", "initials": "E"}], "type": "case reports", "published": "2021-07-20", "journal": {"title": "Clin Med Insights Circ Respir Pulm Med", "issn": "1179-5484", "issn-l": null, "volume": "15", "issue": null, "pages": "11795484211030159"}, "abstract": "V/P SPECT from 4 consecutive patients with COVID-19 suggests that ventilation and perfusion images may be applied to diagnose or exclude pulmonary embolism, verify nonsegmental diversion of perfusion from the ventilated areas (dead space ventilation) that may represent inflammation of the pulmonary vasculature, detect the reversed mismatch of poor ventilation and better preserved perfusion (shunt perfusion) in bilateral pulmonary inflammation and indicate redistribution of lung perfusion (antigravitational hyperperfusion) due to cardiac congestion. V/P mismatch and reversed mismatch may be extensive enough to diminish dramatically preserved matching ventilation/perfusion and to induce severe hypoxemia in COVID-19.", "doi": "10.1177/11795484211030159", "pmid": "34349582", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8295940"}, {"db": "pii", "key": "10.1177_11795484211030159"}], "notes": [], "created": "2021-08-06T09:24:03.461Z", "modified": "2023-06-19T15:03:14.197Z"}, {"entity": "publication", "iuid": "648b7d9ffa0c4927b2654baea33b717e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/648b7d9ffa0c4927b2654baea33b717e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/648b7d9ffa0c4927b2654baea33b717e"}}, "title": "Using a household-structured branching process to analyse contact tracing in the SARS-CoV-2 pandemic.", "authors": [{"family": "Fyles", "given": "Martyn", "initials": "M"}, {"family": "Fearon", "given": "Elizabeth", "initials": "E"}, {"family": "Overton", "given": "Christopher", "initials": "C"}, {"family": "University of Manchester COVID-19 Modelling Group", "given": "", "initials": ""}, {"family": "Wingfield", "given": "Tom", "initials": "T"}, {"family": "Medley", "given": "Graham F", "initials": "GF"}, {"family": "Hall", "given": "Ian", "initials": "I"}, {"family": "Pellis", "given": "Lorenzo", "initials": "L"}, {"family": "House", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2021-07-19", "journal": {"title": "Philos Trans R Soc Lond B Biol Sci", "issn": "1471-2970", "issn-l": null, "volume": "376", "issue": "1829", "pages": "20200267"}, "abstract": "We explore strategies of contact tracing, case isolation and quarantine of exposed contacts to control the SARS-CoV-2 epidemic using a branching process model with household structure. This structure reflects higher transmission risks among household members than among non-household members. We explore strategic implementation choices that make use of household structure, and investigate strategies including two-step tracing, backwards tracing, smartphone tracing and tracing upon symptom report rather than test results. The primary model outcome is the effect of contact tracing, in combination with different levels of physical distancing, on the growth rate of the epidemic. Furthermore, we investigate epidemic extinction times to indicate the time period over which interventions must be sustained. We consider effects of non-uptake of isolation/quarantine, non-adherence, and declining recall of contacts over time. Our results find that, compared to self-isolation of cases without contact tracing, a contact tracing strategy designed to take advantage of household structure allows for some relaxation of physical distancing measures but cannot completely control the epidemic absent of other measures. Even assuming no imported cases and sustainment of moderate physical distancing, testing and tracing efforts, the time to bring the epidemic to extinction could be in the order of months to years. This article is part of the theme issue 'Modelling that shaped the early COVID-19 pandemic response in the UK'.", "doi": "10.1098/rstb.2020.0267", "pmid": "34053253", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "URL", "key": "https://github.com/martyn1fyles/HouseholdContactTracing", "description": "Data and code"}], "notes": [], "created": "2021-06-04T11:32:17.300Z", "modified": "2021-11-18T09:36:35.538Z"}, {"entity": "publication", "iuid": "290c919c0c1b4505aaa40d3d71d3c62f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/290c919c0c1b4505aaa40d3d71d3c62f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/290c919c0c1b4505aaa40d3d71d3c62f"}}, "title": "The collaborative outcomes study on health and functioning during infection times in adults (COH-FIT-Adults): Design and methods of an international online survey targeting physical and mental health effects of the COVID-19 pandemic.", "authors": [{"family": "Solmi", "given": "Marco", "initials": "M"}, {"family": "Estrad\u00e9", "given": "Andr\u00e9s", "initials": "A"}, {"family": "Thompson", "given": "Trevor", "initials": "T"}, {"family": "Agorastos", "given": "Agorastos", "initials": "A"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Cortese", "given": "Samuele", "initials": "S"}, {"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Leisch", "given": "Friedrich", "initials": "F"}, {"family": "Vancampfort", "given": "Davy", "initials": "D"}, {"family": "Thygesen", "given": "Lau Caspar", "initials": "LC"}, {"family": "Aschauer", "given": "Harald", "initials": "H"}, {"family": "Schloegelhofer", "given": "Monika", "initials": "M"}, {"family": "Akimova", "given": "Elena", "initials": "E"}, {"family": "Schneeberger", "given": "Andres", "initials": "A"}, {"family": "Huber", "given": "Christian G", "initials": "CG"}, {"family": "Hasler", "given": "Gregor", "initials": "G"}, {"family": "Conus", "given": "Philippe", "initials": "P"}, {"family": "Cu\u00e9nod", "given": "Kim Q Do", "initials": "KQD"}, {"family": "von K\u00e4nel", "given": "Roland", "initials": "R"}, {"family": "Arrondo", "given": "Gonzalo", "initials": "G"}, {"family": "Fusar-Poli", "given": "Paolo", "initials": "P"}, {"family": "Gorwood", "given": "Philip", "initials": "P"}, {"family": "Llorca", "given": "Pierre-Michel", "initials": "PM"}, {"family": "Krebs", "given": "Marie-Odile", "initials": "MO"}, {"family": "Scanferla", "given": "Elisabetta", "initials": "E"}, {"family": "Kishimoto", "given": "Taishiro", "initials": "T"}, {"family": "Rabbani", "given": "Golam", "initials": "G"}, {"family": "Skonieczna-\u017bydecka", "given": "Karolina", "initials": "K"}, {"family": "Brambilla", "given": "Paolo", "initials": "P"}, {"family": "Favaro", "given": "Angela", "initials": "A"}, {"family": "Takamiya", "given": "Akihiro", "initials": "A"}, {"family": "Zoccante", "given": "Leonardo", "initials": "L"}, {"family": "Colizzi", "given": "Marco", "initials": "M"}, {"family": "Bourgin", "given": "Julie", "initials": "J"}, {"family": "Kami\u0144ski", "given": "Karol", "initials": "K"}, {"family": "Moghadasin", "given": "Maryam", "initials": "M"}, {"family": "Seedat", "given": "Soraya", "initials": "S"}, {"family": "Matthews", "given": "Evan", "initials": "E"}, {"family": "Wells", "given": "John", "initials": "J"}, {"family": "Vassilopoulou", "given": "Emilia", "initials": "E"}, {"family": "Gadelha", "given": "Ary", "initials": "A"}, {"family": "Su", "given": "Kuan-Pin", "initials": "KP"}, {"family": "Kwon", "given": "Jun Soo", "initials": "JS"}, {"family": "Kim", "given": "Minah", "initials": "M"}, {"family": "Lee", "given": "Tae Young", "initials": "TY"}, {"family": "Papsuev", "given": "Oleg", "initials": "O"}, {"family": "Mankov\u00e1", "given": "Denisa", "initials": "D"}, {"family": "Boscutti", "given": "Andrea", "initials": "A"}, {"family": "Gerunda", "given": "Cristiano", "initials": "C"}, {"family": "Saccon", "given": "Diego", "initials": "D"}, {"family": "Righi", "given": "Elena", "initials": "E"}, {"family": "Monaco", "given": "Francesco", "initials": "F"}, {"family": "Croatto", "given": "Giovanni", "initials": "G"}, {"family": "Cereda", "given": "Guido", "initials": "G"}, {"family": "Demurtas", "given": "Jacopo", "initials": "J"}, {"family": "Brondino", "given": "Natascia", "initials": "N"}, {"family": "Veronese", "given": "Nicola", "initials": "N"}, {"family": "Enrico", "given": "Paolo", "initials": "P"}, {"family": "Politi", "given": "Pierluigi", "initials": "P"}, {"family": "Ciappolino", "given": "Valentina", "initials": "V"}, {"family": "Pfennig", "given": "Andrea", "initials": "A"}, {"family": "Bechdolf", "given": "Andreas", "initials": "A"}, {"family": "Meyer-Lindenberg", "given": "Andreas", "initials": "A"}, {"family": "Kahl", "given": "Kai G", "initials": "KG"}, {"family": "Domschke", "given": "Katharina", "initials": "K"}, {"family": "Bauer", "given": "Michael", "initials": "M"}, {"family": "Koutsouleris", "given": "Nikolaos", "initials": "N"}, {"family": "Winter", "given": "Sibylle", "initials": "S"}, {"family": "Borgwardt", "given": "Stefan", "initials": "S"}, {"family": "Bitter", "given": "Istvan", "initials": "I"}, {"family": "Balazs", "given": "Judit", "initials": "J"}, {"family": "Czobor", "given": "Pal", "initials": "P"}, {"family": "Unoka", "given": "Zsolt", "initials": "Z"}, {"family": "Mavridis", "given": "Dimitris", "initials": "D"}, {"family": "Tsamakis", "given": "Konstantinos", "initials": "K"}, {"family": "Bozikas", "given": "Vasilios P", "initials": "VP"}, {"family": "Tunvirachaisakul", "given": "Chavit", "initials": "C"}, {"family": "Maes", "given": "Michael", "initials": "M"}, {"family": "Rungnirundorn", "given": "Teerayuth", "initials": "T"}, {"family": "Supasitthumrong", "given": "Thitiporn", "initials": "T"}, {"family": "Haque", "given": "Ariful", "initials": "A"}, {"family": "Brunoni", "given": "Andre R", "initials": "AR"}, {"family": "Costardi", "given": "Carlos Gustavo", "initials": "CG"}, {"family": "Schuch", "given": "Felipe Barreto", "initials": "FB"}, {"family": "Polanczyk", "given": "Guilherme", "initials": "G"}, {"family": "Luiz", "given": "Jhoanne Merlyn", "initials": "JM"}, {"family": "Fonseca", "given": "Lais", "initials": "L"}, {"family": "Aparicio", "given": "Luana V", "initials": "LV"}, {"family": "Valvassori", "given": "Samira S", "initials": "SS"}, {"family": "Nordentoft", "given": "Merete", "initials": "M"}, {"family": "Vendsborg", "given": "Per", "initials": "P"}, {"family": "Hoffmann", "given": "Sofie Have", "initials": "SH"}, {"family": "Sehli", "given": "Jihed", "initials": "J"}, {"family": "Sartorius", "given": "Norman", "initials": "N"}, {"family": "Heuss", "given": "Sabina", "initials": "S"}, {"family": "Guinart", "given": "Daniel", "initials": "D"}, {"family": "Hamilton", "given": "Jane", "initials": "J"}, {"family": "Kane", "given": "John", "initials": "J"}, {"family": "Rubio", "given": "Jose", "initials": "J"}, {"family": "Sand", "given": "Michael", "initials": "M"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Solanes", "given": "Aleix", "initials": "A"}, {"family": "Andreu-Bernabeu", "given": "Alvaro", "initials": "A"}, {"family": "C\u00e1ceres", "given": "Antonia San Jos\u00e9", "initials": "ASJ"}, {"family": "Arango", "given": "Celso", "initials": "C"}, {"family": "D\u00edaz-Caneja", "given": "Covadonga M", "initials": "CM"}, {"family": "Hidalgo-Mazzei", "given": "Diego", "initials": "D"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Gonzalez-Pe\u00f1as", "given": "Javier", "initials": "J"}, {"family": "Fortea", "given": "Lydia", "initials": "L"}, {"family": "Parellada", "given": "Mara", "initials": "M"}, {"family": "Fullana", "given": "Miquel A", "initials": "MA"}, {"family": "Verdolini", "given": "Norma", "initials": "N"}, {"family": "F\u00e1rkov\u00e1", "given": "Eva", "initials": "E"}, {"family": "Jank\u016f", "given": "Karolina", "initials": "K"}, {"family": "Millan", "given": "Mark", "initials": "M"}, {"family": "Honciuc", "given": "Mihaela", "initials": "M"}, {"family": "Moniuszko-Malinowska", "given": "Anna", "initials": "A"}, {"family": "\u0141oniewski", "given": "Igor", "initials": "I"}, {"family": "Samochowiec", "given": "Jerzy", "initials": "J"}, {"family": "Kiszkiel", "given": "\u0141ukasz", "initials": "\u0141"}, {"family": "Marlicz", "given": "Maria", "initials": "M"}, {"family": "Sowa", "given": "Pawe\u0142", "initials": "P"}, {"family": "Marlicz", "given": "Wojciech", "initials": "W"}, {"family": "Spies", "given": "Georgina", "initials": "G"}, {"family": "Stubbs", "given": "Brendon", "initials": "B"}, {"family": "Firth", "given": "Joseph", "initials": "J"}, {"family": "Sullivan", "given": "Sarah", "initials": "S"}, {"family": "Darcin", "given": "Asli Enez", "initials": "AE"}, {"family": "Aksu", "given": "Hatice", "initials": "H"}, {"family": "Dilbaz", "given": "Nesrin", "initials": "N"}, {"family": "Noyan", "given": "Onur", "initials": "O"}, {"family": "Kitazawa", "given": "Momoko", "initials": "M"}, {"family": "Kurokawa", "given": "Shunya", "initials": "S"}, {"family": "Tazawa", "given": "Yuki", "initials": "Y"}, {"family": "Anselmi", "given": "Alejandro", "initials": "A"}, {"family": "Cracco", "given": "Cecilia", "initials": "C"}, {"family": "Machado", "given": "Ana In\u00e9s", "initials": "AI"}, {"family": "Estrade", "given": "Natalia", "initials": "N"}, {"family": "De Leo", "given": "Diego", "initials": "D"}, {"family": "Curtis", "given": "Jackie", "initials": "J"}, {"family": "Berk", "given": "Michael", "initials": "M"}, {"family": "Ward", "given": "Philip", "initials": "P"}, {"family": "Teasdale", "given": "Scott", "initials": "S"}, {"family": "Rosenbaum", "given": "Simon", "initials": "S"}, {"family": "Marx", "given": "Wolfgang", "initials": "W"}, {"family": "Horodnic", "given": "Adrian Vasile", "initials": "AV"}, {"family": "Oprea", "given": "Liviu", "initials": "L"}, {"family": "Alexinschi", "given": "Ovidiu", "initials": "O"}, {"family": "Ifteni", "given": "Petru", "initials": "P"}, {"family": "Turliuc", "given": "Serban", "initials": "S"}, {"family": "Ciuhodaru", "given": "Tudor", "initials": "T"}, {"family": "Bolos", "given": "Alexandra", "initials": "A"}, {"family": "Matei", "given": "Valentin", "initials": "V"}, {"family": "Nieman", "given": "Dorien H", "initials": "DH"}, {"family": "Sommer", "given": "Iris", "initials": "I"}, {"family": "van Os", "given": "Jim", "initials": "J"}, {"family": "van Amelsvoort", "given": "Therese", "initials": "T"}, {"family": "Sun", "given": "Ching-Fang", "initials": "CF"}, {"family": "Guu", "given": "Ta-Wei", "initials": "TW"}, {"family": "Jiao", "given": "Can", "initials": "C"}, {"family": "Zhang", "given": "Jieting", "initials": "J"}, {"family": "Fan", "given": "Jialin", "initials": "J"}, {"family": "Zou", "given": "Liye", "initials": "L"}, {"family": "Yu", "given": "Xin", "initials": "X"}, {"family": "Chi", "given": "Xinli", "initials": "X"}, {"family": "de Timary", "given": "Philippe", "initials": "P"}, {"family": "van Winke", "given": "Ruud", "initials": "R"}, {"family": "Ng", "given": "Bernardo", "initials": "B"}, {"family": "Pena", "given": "Edilberto", "initials": "E"}, {"family": "Arellano", "given": "Ramon", "initials": "R"}, {"family": "Roman", "given": "Raquel", "initials": "R"}, {"family": "Sanchez", "given": "Thelma", "initials": "T"}, {"family": "Movina", "given": "Larisa", "initials": "L"}, {"family": "Morgado", "given": "Pedro", "initials": "P"}, {"family": "Brissos", "given": "Sofia", "initials": "S"}, {"family": "Aizberg", "given": "Oleg", "initials": "O"}, {"family": "Mosina", "given": "Anna", "initials": "A"}, {"family": "Krinitski", "given": "Damir", "initials": "D"}, {"family": "Mugisha", "given": "James", "initials": "J"}, {"family": "Sadeghi-Bahmani", "given": "Dena", "initials": "D"}, {"family": "Sadeghi", "given": "Masoud", "initials": "M"}, {"family": "Hadi", "given": "Samira", "initials": "S"}, {"family": "Brand", "given": "Serge", "initials": "S"}, {"family": "Errazuriz", "given": "Antonia", "initials": "A"}, {"family": "Crossley", "given": "Nicolas", "initials": "N"}, {"family": "Ristic", "given": "Dragana Ignjatovic", "initials": "DI"}, {"family": "L\u00f3pez-Jaramillo", "given": "Carlos", "initials": "C"}, {"family": "Efthymiou", "given": "Dimitris", "initials": "D"}, {"family": "Kuttichira", "given": "Praveenlal", "initials": "P"}, {"family": "Kallivayalil", "given": "Roy Abraham", "initials": "RA"}, {"family": "Javed", "given": "Afzal", "initials": "A"}, {"family": "Afridi", "given": "Muhammad Iqbal", "initials": "MI"}, {"family": "James", "given": "Bawo", "initials": "B"}, {"family": "Seb-Akahomen", "given": "Omonefe Joy", "initials": "OJ"}, {"family": "Fiedorowicz", "given": "Jess", "initials": "J"}, {"family": "Carvalho", "given": "Andre F", "initials": "AF"}, {"family": "Daskalakis", "given": "Jeff", "initials": "J"}, {"family": "Yatham", "given": "Lakshmi N", "initials": "LN"}, {"family": "Yang", "given": "Lin", "initials": "L"}, {"family": "Okasha", "given": "Tarek", "initials": "T"}, {"family": "Dahdouh", "given": "A\u00efcha", "initials": "A"}, {"family": "Gerdle", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Tiihonen", "given": "Jari", "initials": "J"}, {"family": "Shin", "given": "Jae Il", "initials": "JI"}, {"family": "Lee", "given": "Jinhee", "initials": "J"}, {"family": "Mhalla", "given": "Ahmed", "initials": "A"}, {"family": "Gaha", "given": "Lotfi", "initials": "L"}, {"family": "Brahim", "given": "Takoua", "initials": "T"}, {"family": "Altynbekov", "given": "Kuanysh", "initials": "K"}, {"family": "Negay", "given": "Nikolay", "initials": "N"}, {"family": "Nurmagambetova", "given": "Saltanat", "initials": "S"}, {"family": "Jamei", "given": "Yasser Abu", "initials": "YA"}, {"family": "Weiser", "given": "Mark", "initials": "M"}, {"family": "Correll", "given": "Christoph U", "initials": "CU"}], "type": "journal article", "published": "2021-07-19", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "volume": "299", "pages": "393-407", "issn-l": null}, "abstract": ". High-quality comprehensive data on short-/long-term physical/mental health effects of the COVID-19 pandemic are needed.\n\n. The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) is an international, multi-language (n=30) project involving >230 investigators from 49 countries/territories/regions, endorsed by national/international professional associations. COH-FIT is a multi-wave, on-line anonymous, cross-sectional survey [wave 1: 04/2020 until the end of the pandemic, 12 months waves 2/3 starting 6/24 months threreafter] for adults, adolescents (14-17), and children (6-13), utilizing non-probability/snowball and representative sampling. COH-FIT aims to identify non-modifiable/modifiable risk factors/treatment targets to inform prevention/intervention programs to improve social/health outcomes in the general population/vulnerable subgrous during/after COVID-19. In adults, co-primary outcomes are change from pre-COVID-19 to intra-COVID-19 in well-being (WHO-5) and a composite psychopathology P-Score. Key secondary outcomes are a P-extended score, global mental and physical health. Secondary outcomes include health-service utilization/functioning, treatment adherence, functioning, symptoms/behaviors/emotions, substance use, violence, among others.\n\n. Starting 04/26/2020, up to 14/07/2021 >151,000 people from 155 countries/territories/regions and six continents have participated. Representative samples of \u22651,000 adults have been collected in 15 countries. Overall, 43.0% had prior physical disorders, 16.3% had prior mental disorders, 26.5% were health care workers, 8.2% were aged \u226565 years, 19.3% were exposed to someone infected with COVID-19, 76.1% had been in quarantine, and 2.1% had been COVID 19-positive.\n\n. Cross-sectional survey, preponderance of non-representative participants.\n\n. Results from COH-FIT will comprehensively quantify the impact of COVID-19, seeking to identify high-risk groups in need for acute and long-term intervention, and inform evidence-based health policies/strategies during this/future pandemics.", "doi": "10.1016/j.jad.2021.07.048", "pmid": "34949568", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0165-0327(21)00727-8"}, {"db": "pmc", "key": "PMC8288233"}], "notes": [], "created": "2022-01-04T15:28:29.970Z", "modified": "2022-01-04T15:28:38.000Z"}, {"entity": "publication", "iuid": "63c8ec3fd14f4ad59f7b63fdef28e761", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63c8ec3fd14f4ad59f7b63fdef28e761.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63c8ec3fd14f4ad59f7b63fdef28e761"}}, "title": "Systematic evaluation of SARS-CoV-2 antigens enables a highly specific and sensitive multiplex serological COVID-19 assay.", "authors": [{"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc2c612e12284831866002f6759932d5.json"}}, {"family": "Andersson", "given": "Eni", "initials": "E", "orcid": "0000-0002-5115-0637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8200b399e954f3482aec53a62df3b54.json"}}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/282479e5be7c453691d5be4847018b01.json"}}, {"family": "Jernbom Falk", "given": "August", "initials": "A", "orcid": "0000-0002-7773-1851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40d944d7fa964f4292f10012356a2730.json"}}, {"family": "Bayati", "given": "Shaghayegh", "initials": "S"}, {"family": "Mravinacova", "given": "Sara", "initials": "S"}, {"family": "Sj\u00f6berg", "given": "Ronald", "initials": "R", "orcid": "0000-0003-1363-5796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88fa4197c91348bdb1933006a947a9d1.json"}}, {"family": "Yousef", "given": "Jamil", "initials": "J", "orcid": "0000-0001-5915-1258", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/324e111715fc4029badd136232057025.json"}}, {"family": "Skoglund", "given": "Lovisa", "initials": "L"}, {"family": "Kanje", "given": "Sara", "initials": "S"}, {"family": "Berling", "given": "Anna", "initials": "A"}, {"family": "Svensson", "given": "Anne-Sophie", "initials": "AS"}, {"family": "Jensen", "given": "Gabriella", "initials": "G"}, {"family": "Enstedt", "given": "Henric", "initials": "H"}, {"family": "Afshari", "given": "Delaram", "initials": "D"}, {"family": "Xu", "given": "Lan Lan", "initials": "LL"}, {"family": "Zwahlen", "given": "Martin", "initials": "M"}, {"family": "von Feilitzen", "given": "Kalle", "initials": "K"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Lendel", "given": "Christofer", "initials": "C"}, {"family": "Roth", "given": "Robert G", "initials": "RG"}, {"family": "Skoog", "given": "Ingmar", "initials": "I"}, {"family": "Svenungsson", "given": "Elisabet", "initials": "E"}, {"family": "Olsson", "given": "Tomas", "initials": "T"}, {"family": "Fogdell-Hahn", "given": "Anna", "initials": "A"}, {"family": "Lindroth", "given": "Ylva", "initials": "Y"}, {"family": "Lundgren", "given": "Maria", "initials": "M"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Lagerqvist", "given": "Nina", "initials": "N"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Da Silva Rodrigues", "given": "Rui", "initials": "R"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Arroyo M\u00fchr", "given": "Laila Sara", "initials": "LS"}, {"family": "Eklund", "given": "Carina", "initials": "C"}, {"family": "Lagheden", "given": "Camilla", "initials": "C"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Sivertsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f28f2f6ac9648629c2d2de92fe7bb59.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1345-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a53a433db6f04a458e3d420f0c9995c5.json"}}, {"family": "Tegel", "given": "Hanna", "initials": "H", "orcid": "0000-0002-7067-9173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d3fde7ee5de4dab899746becfae364d.json"}}, {"family": "Pin", "given": "Elisa", "initials": "E", "orcid": "0000-0002-2158-2674", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5568b1a9e3c456c8ee4a95eaa55b103.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c735ef404391493980e4e51d70459ce0.json"}}, {"family": "Hedhammar", "given": "My", "initials": "M", "orcid": "0000-0003-0140-419X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/762482db3e014ccc94527d9e71816c80.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}], "type": "journal article", "published": "2021-07-19", "journal": {"title": "Clin Transl Immunol", "issn": "2050-0068", "issn-l": null, "volume": "10", "issue": "7", "pages": "e1312"}, "abstract": "The COVID-19 pandemic poses an immense need for accurate, sensitive and high-throughput clinical tests, and serological assays are needed for both overarching epidemiological studies and evaluating vaccines. Here, we present the development and validation of a high-throughput multiplex bead-based serological assay.\n\nMore than 100 representations of SARS-CoV-2 proteins were included for initial evaluation, including antigens produced in bacterial and mammalian hosts as well as synthetic peptides. The five best-performing antigens, three representing the spike glycoprotein and two representing the nucleocapsid protein, were further evaluated for detection of IgG antibodies in samples from 331 COVID-19 patients and convalescents, and in 2090 negative controls sampled before 2020.\n\nThree antigens were finally selected, represented by a soluble trimeric form and the S1-domain of the spike glycoprotein as well as by the C-terminal domain of the nucleocapsid. The sensitivity for these three antigens individually was found to be 99.7%, 99.1% and 99.7%, and the specificity was found to be 98.1%, 98.7% and 95.7%. The best assay performance was although achieved when utilising two antigens in combination, enabling a sensitivity of up to 99.7% combined with a specificity of 100%. Requiring any two of the three antigens resulted in a sensitivity of 99.7% and a specificity of 99.4%.\n\nThese observations demonstrate that a serological test based on a combination of several SARS-CoV-2 antigens enables a highly specific and sensitive multiplex serological COVID-19 assay.", "doi": "10.1002/cti2.1312", "pmid": "34295471", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Biobanks for COVID-19 research": null, "Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC8288725"}, {"db": "pii", "key": "CTI21312"}], "notes": [], "created": "2021-08-05T07:13:34.602Z", "modified": "2023-06-19T14:23:26.622Z"}, {"entity": "publication", "iuid": "dda9ad76bb694baa8956651c2effe465", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dda9ad76bb694baa8956651c2effe465.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dda9ad76bb694baa8956651c2effe465"}}, "title": "Subjective mental health and need for care among psychiatric outpatients during the COVID-19 pandemic: Results from an outreach initiative in Sweden.", "authors": [{"family": "Flygare", "given": "Oskar", "initials": "O"}, {"family": "Ivanov", "given": "Volen Z", "initials": "VZ"}, {"family": "S\u00e4ll", "given": "Roland", "initials": "R"}, {"family": "Malaise", "given": "Henrik", "initials": "H"}, {"family": "Ivanova", "given": "Ekaterina", "initials": "E"}, {"family": "R\u00fcck", "given": "Christian", "initials": "C"}, {"family": "Jayaram-Lindstr\u00f6m", "given": "Nitya", "initials": "N"}, {"family": "Martinsson", "given": "Lina", "initials": "L"}], "type": "letter", "published": "2021-07-19", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "volume": "304", "pages": "114124", "issn-l": null}, "abstract": null, "doi": "10.1016/j.psychres.2021.114124", "pmid": "34303944", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(21)00420-0"}, {"db": "pmc", "key": "PMC8288212"}], "notes": [], "created": "2021-08-05T07:03:46.909Z", "modified": "2021-08-05T07:03:46.923Z"}, {"entity": "publication", "iuid": "d7e3f2a78e54439bba3157456d2ec4bc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d7e3f2a78e54439bba3157456d2ec4bc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d7e3f2a78e54439bba3157456d2ec4bc"}}, "title": "Real-time monitoring of COVID-19 dynamics using automated trend fitting and anomaly detection.", "authors": [{"family": "Jombart", "given": "Thibaut", "initials": "T"}, {"family": "Ghozzi", "given": "St\u00e9phane", "initials": "S"}, {"family": "Schumacher", "given": "Dirk", "initials": "D"}, {"family": "Taylor", "given": "Timothy J", "initials": "TJ"}, {"family": "Leclerc", "given": "Quentin J", "initials": "QJ"}, {"family": "Jit", "given": "Mark", "initials": "M"}, {"family": "Flasche", "given": "Stefan", "initials": "S"}, {"family": "Greaves", "given": "Felix", "initials": "F"}, {"family": "Ward", "given": "Tom", "initials": "T"}, {"family": "Eggo", "given": "Rosalind M", "initials": "RM"}, {"family": "Nightingale", "given": "Emily", "initials": "E"}, {"family": "Meakin", "given": "Sophie", "initials": "S"}, {"family": "Brady", "given": "Oliver J", "initials": "OJ"}, {"family": "Centre for Mathematical Modelling of Infectious Diseases COVID-19 Working Group", "given": "", "initials": ""}, {"family": "Medley", "given": "Graham F", "initials": "GF"}, {"family": "H\u00f6hle", "given": "Michael", "initials": "M"}, {"family": "Edmunds", "given": "W John", "initials": "WJ"}], "type": "journal article", "published": "2021-07-19", "journal": {"title": "Philos Trans R Soc Lond B Biol Sci", "issn": "1471-2970", "volume": "376", "issue": "1829", "pages": "20200266", "issn-l": null}, "abstract": "As several countries gradually release social distancing measures, rapid detection of new localized COVID-19 hotspots and subsequent intervention will be key to avoiding large-scale resurgence of transmission. We introduce ASMODEE (automatic selection of models and outlier detection for epidemics), a new tool for detecting sudden changes in COVID-19 incidence. Our approach relies on automatically selecting the best (fitting or predicting) model from a range of user-defined time series models, excluding the most recent data points, to characterize the main trend in an incidence. We then derive prediction intervals and classify data points outside this interval as outliers, which provides an objective criterion for identifying departures from previous trends. We also provide a method for selecting the optimal breakpoints, used to define how many recent data points are to be excluded from the trend fitting procedure. The analysis of simulated COVID-19 outbreaks suggests ASMODEE compares favourably with a state-of-art outbreak-detection algorithm while being simpler and more flexible. As such, our method could be of wider use for infectious disease surveillance. We illustrate ASMODEE using publicly available data of National Health Service (NHS) Pathways reporting potential COVID-19 cases in England at a fine spatial scale, showing that the method would have enabled the early detection of the flare-ups in Leicester and Blackburn with Darwen, two to three weeks before their respective lockdown. ASMODEE is implemented in the free R package trendbreaker. This article is part of the theme issue 'Modelling that shaped the early COVID-19 pandemic response in the UK'.", "doi": "10.1098/rstb.2020.0266", "pmid": "34053271", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-06-04T11:31:18.924Z", "modified": "2021-06-04T11:31:18.946Z"}, {"entity": "publication", "iuid": "121c037fbfa3422092e67e3883f756e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/121c037fbfa3422092e67e3883f756e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/121c037fbfa3422092e67e3883f756e2"}}, "title": "COVID-19 in liver transplant candidates: pretransplant and post-transplant outcomes - an ELITA/ELTR multicentre cohort study.", "authors": [{"family": "Belli", "given": "Luca Saverio", "initials": "LS", "orcid": "0000-0001-8714-2439", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1f6c6e519814fc6b8bf380a6589f41e.json"}}, {"family": "Duvoux", "given": "Christophe", "initials": "C"}, {"family": "Cortesi", "given": "Paolo Angelo", "initials": "PA", "orcid": "0000-0001-5241-4473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24fb5550c396431ba1690caeb044c89c.json"}}, {"family": "Facchetti", "given": "Rita", "initials": "R"}, {"family": "Iacob", "given": "Speranta", "initials": "S"}, {"family": "Perricone", "given": "Giovanni", "initials": "G", "orcid": "0000-0003-3890-5393", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a3f2d16c96f4f9bb38a55d4e9e18921.json"}}, {"family": "Radenne", "given": "Sylvie", "initials": "S"}, {"family": "Conti", "given": "Sara", "initials": "S"}, {"family": "Patrono", "given": "Damiano", "initials": "D"}, {"family": "Berlakovich", "given": "Gabriela", "initials": "G"}, {"family": "Hann", "given": "Angus", "initials": "A"}, {"family": "Pasulo", "given": "Luisa", "initials": "L"}, {"family": "Castells", "given": "Lluis", "initials": "L"}, {"family": "Faitot", "given": "Francois", "initials": "F"}, {"family": "Detry", "given": "Olivier", "initials": "O"}, {"family": "Invernizzi", "given": "Federica", "initials": "F"}, {"family": "Magini", "given": "Giulia", "initials": "G"}, {"family": "De Simone", "given": "Paolo", "initials": "P"}, {"family": "Kounis", "given": "Ilias", "initials": "I", "orcid": "0000-0003-3876-2097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00c977ccd8c541e29f5e2466104bda51.json"}}, {"family": "Morelli", "given": "Maria Cristina", "initials": "MC"}, {"family": "D\u00edaz Fontenla", "given": "Fernando", "initials": "F", "orcid": "0000-0002-4700-0281", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9252ae5865e4e6087766dee75e72d43.json"}}, {"family": "Ericzon", "given": "Bo-G\u00f6ran", "initials": "BG"}, {"family": "Loinaz", "given": "Carmelo", "initials": "C"}, {"family": "Johnston", "given": "Chris", "initials": "C"}, {"family": "Gheorghe", "given": "Liliana", "initials": "L"}, {"family": "Lesurtel", "given": "Mickael", "initials": "M"}, {"family": "Romagnoli", "given": "Renato", "initials": "R", "orcid": "0000-0001-8340-8885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd3f53ab108b4c2e93da4a127460010d.json"}}, {"family": "Kollmann", "given": "Dagmar", "initials": "D"}, {"family": "Perera", "given": "M Thamara Pr", "initials": "MTP"}, {"family": "Fagiuoli", "given": "Stefano", "initials": "S"}, {"family": "Mirza", "given": "Darius", "initials": "D"}, {"family": "Coilly", "given": "Audrey", "initials": "A"}, {"family": "Toso", "given": "Christian", "initials": "C"}, {"family": "Zieniewicz", "given": "Krzysztof", "initials": "K"}, {"family": "Elkrief", "given": "Laure", "initials": "L"}, {"family": "Karam", "given": "Vincent", "initials": "V"}, {"family": "Adam", "given": "Rene", "initials": "R"}, {"family": "den Hoed", "given": "Caroline", "initials": "C"}, {"family": "Merli", "given": "Marco", "initials": "M"}, {"family": "Puoti", "given": "Massimo", "initials": "M"}, {"family": "De Carlis", "given": "Luciano", "initials": "L"}, {"family": "Oniscu", "given": "Gabriel C", "initials": "GC"}, {"family": "Piano", "given": "Salvatore", "initials": "S"}, {"family": "Angeli", "given": "Paolo", "initials": "P", "orcid": "0000-0002-1913-0716", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a88accb32a24526a946dcfa6394f23c.json"}}, {"family": "Fondevila", "given": "Constantino", "initials": "C"}, {"family": "Polak", "given": "Wojciech G", "initials": "WG"}, {"family": "for all the centres contributing to the ELITA-ELTR COVID-19 Registry", "given": "", "initials": ""}], "type": "journal article", "published": "2021-07-19", "journal": {"title": "Gut", "issn": "1468-3288", "issn-l": null}, "abstract": "Explore the impact of COVID-19 on patients on the waiting list for liver transplantation (LT) and on their post-LT course.\n\nData from consecutive adult LT candidates with COVID-19 were collected across Europe in a dedicated registry and were analysed.\n\nFrom 21 February to 20 November 2020, 136 adult cases with laboratory-confirmed SARS-CoV-2 infection from 33 centres in 11 European countries were collected, with 113 having COVID-19. Thirty-seven (37/113, 32.7%) patients died after a median of 18 (10-30) days, with respiratory failure being the major cause (33/37, 89.2%). The 60-day mortality risk did not significantly change between first (35.3%, 95% CI 23.9% to 50.0%) and second (26.0%, 95% CI 16.2% to 40.2%) waves. Multivariable Cox regression analysis showed Laboratory Model for End-stage Liver Disease (Lab-MELD) score of \u226515 (Model for End-stage Liver Disease (MELD) score 15-19, HR 5.46, 95% CI 1.81 to 16.50; MELD score\u226520, HR 5.24, 95% CI 1.77 to 15.55) and dyspnoea on presentation (HR 3.89, 95% CI 2.02 to 7.51) being the two negative independent factors for mortality. Twenty-six patients underwent an LT after a median time of 78.5 (IQR 44-102) days, and 25 (96%) were alive after a median follow-up of 118 days (IQR 31-170).\n\nIncreased mortality in LT candidates with COVID-19 (32.7%), reaching 45% in those with decompensated cirrhosis (DC) and Lab-MELD score of \u226515, was observed, with no significant difference between first and second waves of the pandemic. Respiratory failure was the major cause of death. The dismal prognosis of patients with DC supports the adoption of strict preventative measures and the urgent testing of vaccination efficacy in this population. Prior SARS-CoV-2 symptomatic infection did not affect early post-transplant survival (96%).", "doi": "10.1136/gutjnl-2021-324879", "pmid": "34281984", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "gutjnl-2021-324879"}, {"db": "pmc", "key": "PMC8300535"}], "notes": [], "created": "2021-08-05T11:11:29.008Z", "modified": "2021-08-05T11:11:41.499Z"}, {"entity": "publication", "iuid": "d3d37c8fc405417291432990e06c4214", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3d37c8fc405417291432990e06c4214.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3d37c8fc405417291432990e06c4214"}}, "title": "The effectiveness of psychological interventions for loneliness: A systematic review and meta-analysis.", "authors": [{"family": "Hickin", "given": "Nisha", "initials": "N"}, {"family": "K\u00e4ll", "given": "Anton", "initials": "A"}, {"family": "Shafran", "given": "Roz", "initials": "R"}, {"family": "Sutcliffe", "given": "Sebastian", "initials": "S"}, {"family": "Manzotti", "given": "Grazia", "initials": "G"}, {"family": "Langan", "given": "Dean", "initials": "D"}], "type": "journal article", "published": "2021-07-18", "journal": {"title": "Clin Psychol Rev", "issn": "1873-7811", "volume": "88", "pages": "102066", "issn-l": null}, "abstract": "Chronic loneliness is associated with a range of mental health difficulties. Previous theory and research indicate that psychological interventions show promise for reducing loneliness, however, there have been no systematic reviews or meta-analyses to ascertain the efficacy of these interventions across the lifespan. The aim of this study was to synthesise, meta-analyse and explore the heterogeneity in RCTs of psychological interventions for loneliness in order to establish their efficacy. Five databases (Ovid Embase, Ovid Medline, PsycINFO, Web of Science and CINAHL) were systematically searched in order to identify relevant studies. Included studies were required to be peer-reviewed RCTs examining psychological interventions for loneliness. Two independent coders examined the abstracts of the 3973 studies and 103 full texts, finding 31 studies that met inclusion criteria, 28 of which contained sufficient statistical information to be included in the meta-analysis. The quality of included studies was assessed using the Cochrane Risk of Bias Tool. The 31 studies (N = 3959) that were included in the systematic review were conducted with participants from a diverse range of cultures, age groups and populations. The interventions were of mixed quality and were mostly face to face, group-based and delivered weekly. The most common type of intervention was Cognitive Behavioural Therapy (CBT). 28 studies (N = 3039) were included in a meta-analysis which found that psychological interventions significantly reduced loneliness compared to control groups, yielding a small to medium effect size (g = 0.43). Subgroup analysis and meta-regressions were conducted in order to explore heterogeneity and found that type of psychological intervention was approaching significance as a moderator of the effectiveness of psychological interventions for loneliness. In conclusion, psychological interventions for loneliness across the lifespan are effective. This finding should inform policy makers, researchers and clinicians going forward, especially in the context of increased loneliness due to the COVID-19 pandemic. There was considerable heterogeneity in the effectiveness of the interventions, suggesting that future research should also explore what works for whom and consider personalising psychological treatment.", "doi": "10.1016/j.cpr.2021.102066", "pmid": "34339939", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0272-7358(21)00109-4"}], "notes": [], "created": "2021-08-04T10:10:30.940Z", "modified": "2021-08-04T10:10:30.963Z"}, {"entity": "publication", "iuid": "1ddcdc9140bb4536be76b2b64bf7cf2c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ddcdc9140bb4536be76b2b64bf7cf2c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ddcdc9140bb4536be76b2b64bf7cf2c"}}, "title": "Thrombocytopenia with acute ischemic stroke and bleeding in a patient newly vaccinated with an adenoviral vector-based COVID-19 vaccine: COMMENT: COMMENT from Gruel et al.: RESPONSE from Kahn et al.", "authors": [{"family": "Kahn", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-5566-6350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42eda71f3775400599febc10a4e7359c.json"}}, {"family": "Shannon", "given": "Oongh", "initials": "O", "orcid": "0000-0001-8291-8189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7fad6031e2f4a84a8ede77911d3c542.json"}}, {"family": "Bj\u00f6rck", "given": "Lars", "initials": "L"}], "type": "letter", "published": "2021-07-17", "journal": {"title": "J Thromb Haemost", "issn": "1538-7836", "issn-l": null}, "abstract": "We acknowledge the commentary of Gruel et al. on our recent letter [1] and are pleased that the authors agree that IdeS may be a potential treatment option for the rare but potentially severe IgG-mediated platelet activation observed in complications to vaccination with ChAdOx1 nCoV-19. It is apparent that our respective but distinct expertise with regard to IdeS has led us to develop this hypothesis in parallel. As we clearly cited in our original letter these authors have previously contributed important evidence that IdeS may be beneficial in treating IgG-mediated platelet dysfunction in a mouse model of heparin induced thrombocytopenia [2]. The intention with our letter was to provide more background to IdeS and insight into the unique properties of IdeS that make it suitable for treating many manifestations of IgG-mediated human disease.", "doi": "10.1111/jth.15467", "pmid": "34273222", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:14:15.858Z", "modified": "2021-08-06T07:14:15.903Z"}, {"entity": "publication", "iuid": "8f61ddc00ca64be98849030ad2120659", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f61ddc00ca64be98849030ad2120659.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f61ddc00ca64be98849030ad2120659"}}, "title": "Psychosocial experiences of frontline nurses working in hospital-based settings during the COVID-19 pandemic - A qualitative systematic review.", "authors": [{"family": "Xu", "given": "Hongxuan", "initials": "H"}, {"family": "Stjernsw\u00e4rd", "given": "Sigrid", "initials": "S"}, {"family": "Glasdam", "given": "Stinne", "initials": "S"}], "type": "journal article", "published": "2021-07-17", "journal": {"title": "Int J Nurs Stud Adv", "issn": "2666-142X", "pages": "100037", "issn-l": null}, "abstract": "Frontline nurses have been directly exposed to the SARS-CoV-2 virus and come in close contact with patients during the COVID-19 pandemic. Nurses endorse tasks related to disease control and face multiple psychosocial challenges in their frontline work, potentially affecting their mental well-being and ability to satisfyingly perform their tasks.\n\nTo explore the psychosocial experiences of frontline nurses working in hospital-based settings during the COVID-19 pandemic.\n\nThe qualitative systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. Registered in PROSPERO (CRD42021259111).\n\nLiterature searches were performed through PubMed, CINAHL, and the WHO COVID-19 database. Inclusion criteria were: All types of nurses having direct contact with or taking care of patients; Primary, secondary, and tertiary health-care services admitting and treating COVID-19 patients; Experiences, perceptions, feelings, views in psychosocial aspects from the identified population group; Qualitative studies; Mixed methods studies; Language in English; Published date 2019-2021. Exclusion criteria were: Commentaries; Reviews; Discussion papers; Quantitative studies; Language other than English; Published in 2018 or earlier; Studies without an ethical approval and ethical statement.\n\nThe studies were screened and selected based on the inclusion and exclusion criteria. Quality appraisal was conducted according to the Critical Appraisal Skills Program qualitative study checklist. Data was extracted from included studies and a thematic synthesis was made.\n\nA total of 28 studies were included in the review. The experiences of 1141 nurses from 12 countries were synthesised. Four themes were constructed: 'Nurses' emotional, mental and physical reactions to COVID-19', 'A mix of environmental and personal stressors', 'Internally and externally supported coping strategies', and 'A call for future help and support'.\n\nNurses working frontline during the COVID-19 pandemic have experienced psychological, social, and emotional distress in coping with work demands, social relationships, and their personal life. The results pointed to a need for increased psychological and social support for frontline nurses to cope with stress and maintain mental well-being, which may subsequently affect nursing care outcomes.", "doi": "10.1016/j.ijnsa.2021.100037", "pmid": "34308373", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2666-142X(21)00019-9"}, {"db": "pmc", "key": "PMC8285218"}], "notes": [], "created": "2021-08-05T06:53:13.301Z", "modified": "2021-08-05T06:53:13.329Z"}, {"entity": "publication", "iuid": "1c9b866f37de4b0eb739038e2bd2420e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1c9b866f37de4b0eb739038e2bd2420e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1c9b866f37de4b0eb739038e2bd2420e"}}, "title": "COVID-19: counting migrants in.", "authors": [{"family": "Hargreaves", "given": "Sally", "initials": "S"}, {"family": "Hayward", "given": "Sally E", "initials": "SE"}, {"family": "Noori", "given": "Teymur", "initials": "T"}, {"family": "McKee", "given": "Martin", "initials": "M"}, {"family": "Kumar", "given": "Bernadette", "initials": "B"}], "type": "letter", "published": "2021-07-17", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "398", "issue": "10296", "pages": "211-212", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(21)01339-8", "pmid": "34274061", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)01339-8"}, {"db": "pmc", "key": "PMC8285119"}], "notes": [], "created": "2021-08-06T07:13:37.646Z", "modified": "2021-08-06T07:13:37.649Z"}, {"entity": "publication", "iuid": "ff1ecc2c6bd54e4a808421774175fd27", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff1ecc2c6bd54e4a808421774175fd27.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff1ecc2c6bd54e4a808421774175fd27"}}, "title": "The mechanism behind flaring/triggering of autoimmunity disorders associated with COVID-19.", "authors": [{"family": "Redwan", "given": "Elrashdy M", "initials": "EM"}, {"family": "Alghamdi", "given": "Mohammed F", "initials": "MF"}, {"family": "El-Aziz", "given": "Tarek Mohamed Abd", "initials": "TMA"}, {"family": "Adadi", "given": "Parise", "initials": "P"}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA"}, {"family": "Attrish", "given": "Diksha", "initials": "D"}, {"family": "Azad", "given": "Gajendra Kumar", "initials": "GK"}, {"family": "Baetas-da-Cruz", "given": "Wagner", "initials": "W"}, {"family": "Barh", "given": "Debmalya", "initials": "D"}, {"family": "Bazan", "given": "Nicolas G", "initials": "NG"}, {"family": "Brufsky", "given": "Adam M", "initials": "AM"}, {"family": "Chauhan", "given": "Gaurav", "initials": "G"}, {"family": "Hassan", "given": "S K Sarif", "initials": "SKS"}, {"family": "Kandimalla", "given": "Ramesh", "initials": "R"}, {"family": "Lal", "given": "Amos", "initials": "A"}, {"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Mishra", "given": "Yogendra Kumar", "initials": "YK"}, {"family": "Choudhury", "given": "Pabitra Pal", "initials": "PP"}, {"family": "Pal\u00f9", "given": "Giorgio", "initials": "G"}, {"family": "Panda", "given": "Pritam K", "initials": "PK"}, {"family": "Pizzol", "given": "Damiano", "initials": "D"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Serrano-Aroca", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Seyran", "given": "Murat", "initials": "M"}, {"family": "Takayama", "given": "Kazuo", "initials": "K"}, {"family": "Tambuwala", "given": "Murtaza M", "initials": "MM"}, {"family": "Uhal", "given": "Bruce D", "initials": "BD"}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN"}], "type": "letter", "published": "2021-07-16", "journal": {"title": "Autoimmun Rev", "issn": "1873-0183", "volume": "20", "issue": "10", "pages": "102909", "issn-l": null}, "abstract": null, "doi": "10.1016/j.autrev.2021.102909", "pmid": "34274539", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1568-9972(21)00184-1"}, {"db": "pmc", "key": "PMC8282442"}], "notes": [], "created": "2021-08-05T11:15:20.688Z", "modified": "2021-08-05T11:15:33.836Z"}, {"entity": "publication", "iuid": "9628f3c7ffc54d9a9f25a4b79e80675e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9628f3c7ffc54d9a9f25a4b79e80675e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9628f3c7ffc54d9a9f25a4b79e80675e"}}, "title": "Impacts of the COVID-19 epidemic on the department of stomatology in a tertiary hospital: A case study in the General Hospital of the Central Theater Command, Wuhan, China.", "authors": [{"family": "Dong", "given": "Qingshan", "initials": "Q"}, {"family": "Kuria", "given": "Angelica", "initials": "A"}, {"family": "Weng", "given": "Yanming", "initials": "Y"}, {"family": "Liu", "given": "Yu", "initials": "Y"}, {"family": "Cao", "given": "Yang", "initials": "Y", "orcid": "0000-0002-3552-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7594ca0fdf2d4f238ca04a788a405cdb.json"}}], "type": "journal article", "published": "2021-07-16", "journal": {"title": "Community Dent Oral Epidemiol", "issn": "1600-0528", "issn-l": null}, "abstract": "The impact of the worldwide COVID-19 pandemic on the dental community is evident. Dental education programmes and academic activities have suffered from the ramifications of the pandemic. This study aimed to depict the impacts of the COVID-19 epidemic on the clinical services and academic activities in the department of stomatology of a tertiary hospital in Wuhan, China.\n\nWe obtained historical data of the Department of Stomatology from the Health Information System of the General Hospital of Central Theater Command, Wuhan, China between January 2018 and June 2020. Mean, standard deviation and median with interquartile range were used to summarize the variables. Line plots were used to illustrate the temporal trend. The Kruskal-Wallis equality-of-populations rank test was used to compare the difference between groups.\n\nA significant decrease was noted in the monthly average number of patients seeking outpatient services for the year 2020, which were decreased by two-thirds from 2018 to 2020. The number of emergency cases also decreased significantly by 57.6% in 2020. The monthly number of teaching hours decreased from 3.8 \u00b1 1.5 in 2018 and 4.7 \u00b1 1.4 in 2019 to 1.7 \u00b1 1.9 in 2020. The number of interns also decreased by more than 77.0% in 2020.\n\nThe impacts of COVID-19 in the stomatology clinic were significant with notable decreases in clinical services and education offered to the stomatology students. There is a need to find solutions to keep as many dental professionals as needed remaining on the frontline of oral health care.", "doi": "10.1111/cdoe.12680", "pmid": "34270106", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:15:46.033Z", "modified": "2021-08-06T07:15:46.092Z"}, {"entity": "publication", "iuid": "7a85e9c9d7584294bc016757ec2c0457", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a85e9c9d7584294bc016757ec2c0457.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a85e9c9d7584294bc016757ec2c0457"}}, "title": "COVID-19: the turning point for gender equality.", "authors": [{"family": "Fisseha", "given": "Senait", "initials": "S"}, {"family": "Sen", "given": "Gita", "initials": "G"}, {"family": "Ghebreyesus", "given": "Tedros Adhanom", "initials": "TA"}, {"family": "Byanyima", "given": "Winnie", "initials": "W"}, {"family": "Diniz", "given": "Debora", "initials": "D"}, {"family": "Fore", "given": "Henrietta H", "initials": "HH"}, {"family": "Kanem", "given": "Natalia", "initials": "N"}, {"family": "Karlsson", "given": "Ulrika", "initials": "U"}, {"family": "Khosla", "given": "Rajat", "initials": "R"}, {"family": "Laski", "given": "Laura", "initials": "L"}, {"family": "Mired", "given": "Dina", "initials": "D"}, {"family": "Mlambo-Ngcuka", "given": "Phumzile", "initials": "P"}, {"family": "Mofokeng", "given": "Tlaleng", "initials": "T"}, {"family": "Gupta", "given": "Geeta Rao", "initials": "GR"}, {"family": "Steiner", "given": "Achim", "initials": "A"}, {"family": "Remme", "given": "Michelle", "initials": "M"}, {"family": "Allotey", "given": "Pascale", "initials": "P"}], "type": "journal article", "published": "2021-07-16", "journal": {"title": "Lancet", "issn": "1474-547X", "issn-l": "0140-6736", "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/S0140-6736(21)01651-2", "pmid": "34280381", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)01651-2"}], "notes": [], "created": "2021-08-05T11:12:05.803Z", "modified": "2022-11-23T08:55:18.950Z"}, {"entity": "publication", "iuid": "4cd20fd2bdb64f5e87475df7bb09b952", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4cd20fd2bdb64f5e87475df7bb09b952.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4cd20fd2bdb64f5e87475df7bb09b952"}}, "title": "COVID-19 vaccine acceptance and hesitancy in low- and middle-income countries.", "authors": [{"family": "Sol\u00eds Arce", "given": "Julio S", "initials": "JS", "orcid": "0000-0002-0759-4142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a550afd02b5045898e009f00555d5de1.json"}}, {"family": "Warren", "given": "Shana S", "initials": "SS", "orcid": "0000-0002-2096-1402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9fc163cf8da54bbc85ee05b5fdc233f5.json"}}, {"family": "Meriggi", "given": "Niccol\u00f2 F", "initials": "NF", "orcid": "0000-0002-6757-1284", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04af70c72e0142439785ce0468521588.json"}}, {"family": "Scacco", "given": "Alexandra", "initials": "A", "orcid": "0000-0002-7282-2762", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74d1a467dea7477dabe24a2e178e0efb.json"}}, {"family": "McMurry", "given": "Nina", "initials": "N", "orcid": "0000-0003-3974-3170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2165ef7ad1d476faf3c6ef8b99019c3.json"}}, {"family": "Voors", "given": "Maarten", "initials": "M"}, {"family": "Syunyaev", "given": "Georgiy", "initials": "G"}, {"family": "Malik", "given": "Amyn Abdul", "initials": "AA", "orcid": "0000-0003-4875-9916", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be5d083c5e424b3cb0a828fc7f0e7e9a.json"}}, {"family": "Aboutajdine", "given": "Samya", "initials": "S"}, {"family": "Adeojo", "given": "Opeyemi", "initials": "O"}, {"family": "Anigo", "given": "Deborah", "initials": "D"}, {"family": "Armand", "given": "Alex", "initials": "A", "orcid": "0000-0003-1326-7348", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4e3e32500464ea2b4579d9755efb01d.json"}}, {"family": "Asad", "given": "Saher", "initials": "S"}, {"family": "Atyera", "given": "Martin", "initials": "M"}, {"family": "Augsburg", "given": "Britta", "initials": "B"}, {"family": "Awasthi", "given": "Manisha", "initials": "M"}, {"family": "Ayesiga", "given": "Gloria Eden", "initials": "GE"}, {"family": "Bancalari", "given": "Antonella", "initials": "A"}, {"family": "Bj\u00f6rkman Nyqvist", "given": "Martina", "initials": "M"}, {"family": "Borisova", "given": "Ekaterina", "initials": "E"}, {"family": "Bosancianu", "given": "Constantin Manuel", "initials": "CM", "orcid": "0000-0001-7950-9798", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/97f42ea2eb8a4b019c851b2a3928b10e.json"}}, {"family": "Cabra Garc\u00eda", "given": "Magarita Rosa", "initials": "MR"}, {"family": "Cheema", "given": "Ali", "initials": "A"}, {"family": "Collins", "given": "Elliott", "initials": "E"}, {"family": "Cuccaro", "given": "Filippo", "initials": "F"}, {"family": "Farooqi", "given": "Ahsan Zia", "initials": "AZ"}, {"family": "Fatima", "given": "Tatheer", "initials": "T"}, {"family": "Fracchia", "given": "Mattia", "initials": "M"}, {"family": "Galindo Soria", "given": "Mery Len", "initials": "ML"}, {"family": "Guariso", "given": "Andrea", "initials": "A", "orcid": "0000-0003-2128-7322", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0d94919ffa548bc8b77f2b454af38b9.json"}}, {"family": "Hasanain", "given": "Ali", "initials": "A"}, {"family": "Jaramillo", "given": "Sof\u00eda", "initials": "S"}, {"family": "Kallon", "given": "Sellu", "initials": "S"}, {"family": "Kamwesigye", "given": "Anthony", "initials": "A"}, {"family": "Kharel", "given": "Arjun", "initials": "A"}, {"family": "Kreps", "given": "Sarah", "initials": "S"}, {"family": "Levine", "given": "Madison", "initials": "M"}, {"family": "Littman", "given": "Rebecca", "initials": "R"}, {"family": "Malik", "given": "Mohammad", "initials": "M"}, {"family": "Manirabaruta", "given": "Gisele", "initials": "G"}, {"family": "Mfura", "given": "Jean L\u00e9odomir Habarimana", "initials": "JLH"}, {"family": "Momoh", "given": "Fatoma", "initials": "F"}, {"family": "Mucauque", "given": "Alberto", "initials": "A"}, {"family": "Mussa", "given": "Imamo", "initials": "I"}, {"family": "Nsabimana", "given": "Jean Aime", "initials": "JA"}, {"family": "Obara", "given": "Isaac", "initials": "I"}, {"family": "Ot\u00e1lora", "given": "Mar\u00eda Juliana", "initials": "MJ"}, {"family": "Ou\u00e9draogo", "given": "B\u00e9chir Wendemi", "initials": "BW"}, {"family": "Pare", "given": "Touba Bakary", "initials": "TB"}, {"family": "Platas", "given": "Melina R", "initials": "MR"}, {"family": "Polanco", "given": "Laura", "initials": "L"}, {"family": "Qureshi", "given": "Javaeria Ashraf", "initials": "JA"}, {"family": "Raheem", "given": "Mariam", "initials": "M"}, {"family": "Ramakrishna", "given": "Vasudha", "initials": "V"}, {"family": "Rendr\u00e1", "given": "Ismail", "initials": "I"}, {"family": "Shah", "given": "Taimur", "initials": "T"}, {"family": "Shaked", "given": "Sarene Eyla", "initials": "SE"}, {"family": "Shapiro", "given": "Jacob N", "initials": "JN", "orcid": "0000-0002-7484-229X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac5199c2900d43528cd55e05477568f7.json"}}, {"family": "Svensson", "given": "Jakob", "initials": "J"}, {"family": "Tariq", "given": "Ahsan", "initials": "A"}, {"family": "Tchibozo", "given": "Achille Mignondo", "initials": "AM"}, {"family": "Tiwana", "given": "Hamid Ali", "initials": "HA"}, {"family": "Trivedi", "given": "Bhartendu", "initials": "B"}, {"family": "Vernot", "given": "Corey", "initials": "C"}, {"family": "Vicente", "given": "Pedro C", "initials": "PC"}, {"family": "Weissinger", "given": "Laurin B", "initials": "LB"}, {"family": "Zafar", "given": "Basit", "initials": "B"}, {"family": "Zhang", "given": "Baobao", "initials": "B", "orcid": "0000-0001-7217-5035", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/929146a8be5e42f3bfffcfafc832897f.json"}}, {"family": "Karlan", "given": "Dean", "initials": "D"}, {"family": "Callen", "given": "Michael", "initials": "M"}, {"family": "Teachout", "given": "Matthieu", "initials": "M"}, {"family": "Humphreys", "given": "Macartan", "initials": "M", "orcid": "0000-0001-7029-2326", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb6b3ca6ea5c4a1cbfdf7d267a54681f.json"}}, {"family": "Mobarak", "given": "Ahmed Mushfiq", "initials": "AM", "orcid": "0000-0002-1916-3438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e85f61d8aa4409b9ffda626a51992c3.json"}}, {"family": "Omer", "given": "Saad B", "initials": "SB", "orcid": "0000-0002-5383-3474", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e884245e39b4a56945252223e3ca7d1.json"}}], "type": "journal article", "published": "2021-07-16", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956", "volume": null, "issue": null, "pages": null}, "abstract": "Widespread acceptance of COVID-19 vaccines is crucial for achieving sufficient immunization coverage to end the global pandemic, yet few studies have investigated COVID-19 vaccination attitudes in lower-income countries, where large-scale vaccination is just beginning. We analyze COVID-19 vaccine acceptance across 15 survey samples covering 10 low- and middle-income countries (LMICs) in Asia, Africa and South America, Russia (an upper-middle-income country) and the United States, including a total of 44,260 individuals. We find considerably higher willingness to take a COVID-19 vaccine in our LMIC samples (mean 80.3%; median 78%; range 30.1 percentage points) compared with the United States (mean 64.6%) and Russia (mean 30.4%). Vaccine acceptance in LMICs is primarily explained by an interest in personal protection against COVID-19, while concern about side effects is the most common reason for hesitancy. Health workers are the most trusted sources of guidance about COVID-19 vaccines. Evidence from this sample of LMICs suggests that prioritizing vaccine distribution to the Global South should yield high returns in advancing global immunization coverage. Vaccination campaigns should focus on translating the high levels of stated acceptance into actual uptake. Messages highlighting vaccine efficacy and safety, delivered by healthcare workers, could be effective for addressing any remaining hesitancy in the analyzed LMICs.", "doi": "10.1038/s41591-021-01454-y", "pmid": "34272499", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-021-01454-y"}, {"db": "URL", "key": "https://github.com/wzb-ipi/covid_vaccines_nmed", "description": "Individual participant data (de-identified), analytic code and replication file"}], "notes": [], "created": "2021-08-06T07:15:21.576Z", "modified": "2021-11-18T09:32:07.573Z"}, {"entity": "publication", "iuid": "6a7b600ff4f5428ab46a9fbca3f25d5f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a7b600ff4f5428ab46a9fbca3f25d5f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a7b600ff4f5428ab46a9fbca3f25d5f"}}, "title": "Swedish Primary Care Physicians' Intentions to Use Telemedicine: A Survey Using a New Questionnaire - Physician Attitudes and Intentions to Use Telemedicine (PAIT).", "authors": [{"family": "Pikkemaat", "given": "Miriam", "initials": "M", "orcid": "0000-0002-9808-207X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb63140be25f4d13a430425313f1b209.json"}}, {"family": "Thulesius", "given": "Hans", "initials": "H", "orcid": "0000-0002-3785-5630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f7d45ab8dd94b89873fb2e44a0a8770.json"}}, {"family": "Milos Nymberg", "given": "Veronica", "initials": "V", "orcid": "0000-0002-3836-3048", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b591c9689b44c7c884187d0827e84a4.json"}}], "type": "journal article", "published": "2021-07-15", "journal": {"title": "Int J Gen Med", "issn": "1178-7074", "volume": "14", "pages": "3445-3455", "issn-l": null}, "abstract": "Research on intentions to use telemedicine in primary care is sparse. This survey study explored primary care physicians' intentions to use telemedicine by using a newly developed questionnaire: Physician Attitudes and Intentions to use Telemedicine.\n\nAn anonymous web-survey with questions focusing on theory-based predictors of behavioral intentions such as Attitudes, Subjective norms and Perceived behavioral control was designed, validated, and sent to all primary care physicians at 160 primary health care centers in southern Sweden from May to August 2019. The questionnaire had 29 subject items (including 49 multiple-choice sub-items). Main outcome measures were intentions to use three domains of telemedicine and correlation between theory-based predictors and behavioral intentions for using telemedicine.\n\nThe survey was validated by an expert group, amended, and then tested and retested. A majority of the 198 physicians who returned the web-surveys reported that they did not use e-mails (68%), nor video consultations (78%), chat (81%), or text messages (86%) in their everyday patient work. Yet, most physicians described a positive intention to use telemedicine in patient care for all three studied domains with Attitudes and Perceived behavioral control being significant predictors (p<0.01) for Intentions to use digital contacts (R2 = 0.54), chronic disease monitoring with digital tools (R2 = 0.47) and artificial intelligence (R2 = 0.54). A structural validation of a preliminary instrument - Physician Attitudes and Intention to use Telemedicine (PAIT) - containing 28 sub-items was done by exploratory factor analysis with acceptable explanatory, reliability and sampling adequacy measures. Five factors emerged with Eigenvalues between 1.6 and 11.1 explaining 72% of the variance. Total Cronbach's alpha was 0.91 and Kaiser-Meyer-Olkirk 0.79.\n\nBefore the covid-19 pandemic, Swedish primary care physicians reported a low use yet high behavioral intention to use telemedicine in a study where we developed the preliminary instrument Physician Attitudes and Intention to use Telemedicine. Perceived behavioral control had the largest predictive value of behavioral intention to use telemedicine. Thus, interventions aiming to increase the use of digital tools in primary care should possibly focus on empowering physicians' self-efficacy towards using them.", "doi": "10.2147/IJGM.S319497", "pmid": "34295177", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "319497"}, {"db": "pmc", "key": "PMC8290350"}], "notes": [], "created": "2021-08-05T11:07:17.298Z", "modified": "2021-08-05T11:07:17.397Z"}, {"entity": "publication", "iuid": "699431106f864e8b87a9e02f13caa5dc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/699431106f864e8b87a9e02f13caa5dc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/699431106f864e8b87a9e02f13caa5dc"}}, "title": "Potential natural polymer-based nanofibres for the development of facemasks in countering viral outbreaks.", "authors": [{"family": "Shanmugam", "given": "Vigneshwaran", "initials": "V"}, {"family": "Babu", "given": "Karthik", "initials": "K"}, {"family": "Garrison", "given": "Thomas F", "initials": "TF"}, {"family": "Capezza", "given": "Antonio J", "initials": "AJ"}, {"family": "Olsson", "given": "Richard T", "initials": "RT"}, {"family": "Ramakrishna", "given": "Seeram", "initials": "S"}, {"family": "Hedenqvist", "given": "Mikael S", "initials": "MS"}, {"family": "Singha", "given": "Shuvra", "initials": "S"}, {"family": "Bartoli", "given": "Mattia", "initials": "M"}, {"family": "Giorcelli", "given": "Mauro", "initials": "M"}, {"family": "Sas", "given": "Gabriel", "initials": "G"}, {"family": "F\u00f6rsth", "given": "Michael", "initials": "M"}, {"family": "Das", "given": "Oisik", "initials": "O", "orcid": "0000-0002-5474-1512", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8b8e5009c55423ba971d148bbe6e7f3.json"}}, {"family": "Rest\u00e1s", "given": "\u00c1goston", "initials": "\u00c1"}, {"family": "Berto", "given": "Filippo", "initials": "F"}], "type": "journal article", "published": "2021-07-15", "journal": {"title": "J Appl Polym Sci", "issn": "0021-8995", "volume": "138", "issue": "27", "pages": "50658", "issn-l": null}, "abstract": "The global coronavirus disease 2019 (COVID-19) pandemic has rapidly increased the demand for facemasks as a measure to reduce the rapid spread of the pathogen. Throughout the pandemic, some countries such as Italy had a monthly demand of ca. 90 million facemasks. Domestic mask manufacturers are capable of manufacturing 8 million masks each week, although the demand was 40 million per week during March 2020. This dramatic increase has contributed to a spike in the generation of facemask waste. Facemasks are often manufactured with synthetic materials that are non-biodegradable, and their increased usage and improper disposal are raising environmental concerns. Consequently, there is a strong interest for developing biodegradable facemasks made with for example, renewable nanofibres. A range of natural polymer-based nanofibres has been studied for their potential to be used in air filter applications. This review article examines potential natural polymer-based nanofibres along with their filtration and antimicrobial capabilities for developing biodegradable facemask that will promote a cleaner production.", "doi": "10.1002/app.50658", "pmid": "34149062", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "APP50658"}, {"db": "pmc", "key": "PMC8206777"}], "notes": [], "created": "2021-06-28T18:25:24.367Z", "modified": "2021-06-28T18:25:41.850Z"}, {"entity": "publication", "iuid": "0b057b65dd734658b81f1de2a041377d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b057b65dd734658b81f1de2a041377d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b057b65dd734658b81f1de2a041377d"}}, "title": "Characteristics and outcomes of 627 044 COVID-19 patients living with and without obesity in the United States, Spain, and the United Kingdom.", "authors": [{"family": "Recalde", "given": "Martina", "initials": "M"}, {"family": "Roel", "given": "Elena", "initials": "E", "orcid": "0000-0002-1964-3546", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad1d9cc65d3242339540f938eeceafe1.json"}}, {"family": "Pistillo", "given": "Andrea", "initials": "A", "orcid": "0000-0002-4467-0220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/055156368b8845a0bfdc522a53cc1b0d.json"}}, {"family": "Sena", "given": "Anthony G", "initials": "AG", "orcid": "0000-0001-8630-5347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9202e069d9c24646b006b6abb640b541.json"}}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A", "orcid": "0000-0003-1202-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47f086bb6ccd49a2a5f11a32c06277c8.json"}}, {"family": "Ahmed", "given": "Waheed-Ul-Rahman", "initials": "W"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM", "orcid": "0000-0002-5630-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5162aab03bc04dafa809108461f18667.json"}}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Areia", "given": "Carlos", "initials": "C", "orcid": "0000-0002-4668-7069", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7232f54be5df43f0b984d0117d88a054.json"}}, {"family": "Burn", "given": "Edward", "initials": "E"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "Dawoud", "given": "Dalia", "initials": "D"}, {"family": "DuVall", "given": "Scott L", "initials": "SL"}, {"family": "Falconer", "given": "Thomas", "initials": "T"}, {"family": "Fern\u00e1ndez-Bertol\u00edn", "given": "Sergio", "initials": "S"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Gong", "given": "Mengchun", "initials": "M"}, {"family": "Lai", "given": "Lana Yin Hui", "initials": "LYH"}, {"family": "Lane", "given": "Jennifer C E", "initials": "JCE"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Mehta", "given": "Paras P", "initials": "PP"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Natarjan", "given": "Karthik", "initials": "K"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Reich", "given": "Christian G", "initials": "CG"}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR"}, {"family": "Schilling", "given": "Lisa M", "initials": "LM"}, {"family": "Shah", "given": "Karishma", "initials": "K"}, {"family": "Shah", "given": "Nigam H", "initials": "NH"}, {"family": "Subbian", "given": "Vignesh", "initials": "V"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhu", "given": "Hong", "initials": "H"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}], "type": "journal article", "published": "2021-07-15", "journal": {"title": "Int J Obes (Lond)", "issn": "1476-5497", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "A detailed characterization of patients with COVID-19 living with obesity has not yet been undertaken. We aimed to describe and compare the demographics, medical conditions, and outcomes of COVID-19 patients living with obesity (PLWO) to those of patients living without obesity.\r\n\r\nWe conducted a cohort study based on outpatient/inpatient care and claims data from January to June 2020 from Spain, the UK, and the US. We used six databases standardized to the OMOP common data model. We defined two non-mutually exclusive cohorts of patients diagnosed and/or hospitalized with COVID-19; patients were followed from index date to 30 days or death. We report the frequency of demographics, prior medical conditions, and 30-days outcomes (hospitalization, events, and death) by obesity status.\r\n\r\nWe included 627 044 (Spain: 122 058, UK: 2336, and US: 502 650) diagnosed and 160 013 (Spain: 18 197, US: 141 816) hospitalized patients with COVID-19. The prevalence of obesity was higher among patients hospitalized (39.9%, 95%CI: 39.8-40.0) than among those diagnosed with COVID-19 (33.1%; 95%CI: 33.0-33.2). In both cohorts, PLWO were more often female. Hospitalized PLWO were younger than patients without obesity. Overall, COVID-19 PLWO were more likely to have prior medical conditions, present with cardiovascular and respiratory events during hospitalization, or require intensive services compared to COVID-19 patients without obesity.\r\n\r\nWe show that PLWO differ from patients without obesity in a wide range of medical conditions and present with more severe forms of COVID-19, with higher hospitalization rates and intensive services requirements. These findings can help guiding preventive strategies of COVID-19 infection and complications and generating hypotheses for causal inference studies.", "doi": "10.1038/s41366-021-00893-4", "pmid": "34267326", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41366-021-00893-4"}, {"db": "pmc", "key": "PMC8281807"}, {"db": "URL", "key": "https://github.com/ohdsi-studies/Covid19CharacterizationCharybdis", "description": "Analytic code"}], "notes": [], "created": "2021-08-06T07:17:27.168Z", "modified": "2021-11-18T09:18:58.826Z"}, {"entity": "publication", "iuid": "4ddc361323c5468eab930e96219f795c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ddc361323c5468eab930e96219f795c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ddc361323c5468eab930e96219f795c"}}, "title": "The Impact of Stress on Health in Childhood and Adolescence in the Era of the COVID-19 Pandemic.", "authors": [{"family": "Cianfarani", "given": "Stefano", "initials": "S"}, {"family": "Pampanini", "given": "Valentina", "initials": "V"}], "type": "journal article", "published": "2021-07-14", "journal": {"title": "Horm Res Paediatr", "issn": "1663-2826", "pages": "1-5", "issn-l": "1663-2818"}, "abstract": "The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is posing many challenges to global health. Efforts from the whole scientific community have shed light on the pathogenetic mechanisms and the clinical features of SARS-CoV-2 infection as well as on potential therapeutic strategies.\n\nThe consequences of stress related to social isolation and anxiety generated by the pandemic on mental and physical health are collateral effects that are yet poorly investigated.", "doi": "10.1159/000517460", "pmid": "34261075", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "000517460"}], "notes": [], "created": "2021-08-06T07:19:08.206Z", "modified": "2021-08-06T07:19:45.627Z"}, {"entity": "publication", "iuid": "e94c3a552cb04f328a59e337030ffa31", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e94c3a552cb04f328a59e337030ffa31.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e94c3a552cb04f328a59e337030ffa31"}}, "title": "Host-Pathogen Adhesion as the Basis of Innovative Diagnostics for Emerging Pathogens.", "authors": [{"family": "van Belkum", "given": "Alex", "initials": "A", "orcid": "0000-0001-8545-5108", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d38c5ad8612e40d89df78b7e4fbd1ce3.json"}}, {"family": "Almeida", "given": "Carina", "initials": "C"}, {"family": "Bardiaux", "given": "Benjamin", "initials": "B", "orcid": "0000-0003-4014-9195", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef17bbca06e94bb4afdda56f85ac801c.json"}}, {"family": "Barrass", "given": "Sarah V", "initials": "SV"}, {"family": "Butcher", "given": "Sarah J", "initials": "SJ"}, {"family": "\u00c7aykara", "given": "Tu\u011f\u00e7e", "initials": "T"}, {"family": "Chowdhury", "given": "Sounak", "initials": "S"}, {"family": "Datar", "given": "Rucha", "initials": "R"}, {"family": "Eastwood", "given": "Ian", "initials": "I"}, {"family": "Goldman", "given": "Adrian", "initials": "A"}, {"family": "Goyal", "given": "Manisha", "initials": "M"}, {"family": "Happonen", "given": "Lotta", "initials": "L"}, {"family": "Izadi-Pruneyre", "given": "Nadia", "initials": "N"}, {"family": "Jacobsen", "given": "Theis", "initials": "T"}, {"family": "Johnson", "given": "Pirjo H", "initials": "PH"}, {"family": "Kempf", "given": "Volkhard A J", "initials": "VAJ"}, {"family": "Kiessling", "given": "Andreas", "initials": "A"}, {"family": "Bueno", "given": "Juan Leva", "initials": "JL"}, {"family": "Malik", "given": "Anchal", "initials": "A"}, {"family": "Malmstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0002-2889-7169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e42dacb3a60b456dbbfb3e0a0c51a606.json"}}, {"family": "Meuskens", "given": "Ina", "initials": "I"}, {"family": "Milner", "given": "Paul A", "initials": "PA"}, {"family": "Nilges", "given": "Michael", "initials": "M"}, {"family": "Pamme", "given": "Nicole", "initials": "N", "orcid": "0000-0002-9391-9387", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1000b4c42944339b4f3eedf7a7deb8b.json"}}, {"family": "Peyman", "given": "Sally A", "initials": "SA", "orcid": "0000-0002-1600-5100", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f53dab03308c44ca98d7af152064b37e.json"}}, {"family": "Rodrigues", "given": "Ligia R", "initials": "LR", "orcid": "0000-0001-9265-0630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dcb8d38170cd4c3a80047faf3771246c.json"}}, {"family": "Rodriguez-Mateos", "given": "Pablo", "initials": "P"}, {"family": "Sande", "given": "Maria G", "initials": "MG"}, {"family": "Silva", "given": "Carla Joana", "initials": "CJ"}, {"family": "Stasiak", "given": "Aleksandra Cecylia", "initials": "AC", "orcid": "0000-0001-6914-5740", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d91d81aaa6b4328b45f43a294276ae0.json"}}, {"family": "Stehle", "given": "Thilo", "initials": "T"}, {"family": "Thibau", "given": "Arno", "initials": "A"}, {"family": "Vaca", "given": "Diana J", "initials": "DJ"}, {"family": "Linke", "given": "Dirk", "initials": "D"}], "type": "journal article", "published": "2021-07-14", "journal": {"title": "Diagnostics (Basel)", "issn": "2075-4418", "volume": "11", "issue": "7", "issn-l": null}, "abstract": "Infectious diseases are an existential health threat, potentiated by emerging and re-emerging viruses and increasing bacterial antibiotic resistance. Targeted treatment of infectious diseases requires precision diagnostics, especially in cases where broad-range therapeutics such as antibiotics fail. There is thus an increasing need for new approaches to develop sensitive and specific in vitro diagnostic (IVD) tests. Basic science and translational research are needed to identify key microbial molecules as diagnostic targets, to identify relevant host counterparts, and to use this knowledge in developing or improving IVD. In this regard, an overlooked feature is the capacity of pathogens to adhere specifically to host cells and tissues. The molecular entities relevant for pathogen-surface interaction are the so-called adhesins. Adhesins vary from protein compounds to (poly-)saccharides or lipid structures that interact with eukaryotic host cell matrix molecules and receptors. Such interactions co-define the specificity and sensitivity of a diagnostic test. Currently, adhesin-receptor binding is typically used in the pre-analytical phase of IVD tests, focusing on pathogen enrichment. Further exploration of adhesin-ligand interaction, supported by present high-throughput \"omics\" technologies, might stimulate a new generation of broadly applicable pathogen detection and characterization tools. This review describes recent results of novel structure-defining technologies allowing for detailed molecular analysis of adhesins, their receptors and complexes. Since the host ligands evolve slowly, the corresponding adhesin interaction is under selective pressure to maintain a constant receptor binding domain. IVD should exploit such conserved binding sites and, in particular, use the human ligand to enrich the pathogen. We provide an inventory of methods based on adhesion factors and pathogen attachment mechanisms, which can also be of relevance to currently emerging pathogens, including SARS-CoV-2, the causative agent of COVID-19.", "doi": "10.3390/diagnostics11071259", "pmid": "34359341", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "diagnostics11071259"}, {"db": "pmc", "key": "PMC8305138"}], "notes": [], "created": "2021-08-11T14:37:57.779Z", "modified": "2021-08-11T14:37:57.951Z"}, {"entity": "publication", "iuid": "78b963daa11f420b89353538b366bd7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/78b963daa11f420b89353538b366bd7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/78b963daa11f420b89353538b366bd7e"}}, "title": "Fear and anxiety in the face of COVID-19: Negative dispositions towards risk and uncertainty as vulnerability factors.", "authors": [{"family": "Millroth", "given": "Philip", "initials": "P"}, {"family": "Frey", "given": "Renato", "initials": "R"}], "type": "journal article", "published": "2021-07-14", "journal": {"title": "J Anxiety Disord", "issn": "1873-7897", "issn-l": null, "volume": "83", "issue": null, "pages": "102454"}, "abstract": "In the face of the COVID-19 pandemic it is important to identify factors that make people particularly vulnerable of developing mental-health issues in order to provide case-specific treatments. In this article, we examine the roles of two psychological constructs - originally put forth in the behavioral decision sciences - in predicting interindividual differences in fear responses: general risk aversion (GRA) and intolerance of uncertainty (IU). We first provide a review of these constructs and illustrate why they may play important roles in shaping anxiety-related disorders. Thereafter we present an empirical study that collected survey data from 550 U.S. residents, comprising self-assessments of dispositions towards risk and uncertainty, anxiety- and depression levels, as well as demographic variables - to thus test the extent to which these psychological constructs are predictive of strong fear responses related to COVID-19 (i.e., mortal fear, racing heart). The results from Bayesian multi-model inference analyses showed that GRA and IU were more powerful predictors of fear responses than demographic variables. Moreover, the predictive power of these constructs was independent of general anxiety- and depression levels. Subsequent mediation analyses showed that the effects of GRA and IU were both direct and indirect via anxiety. We conclude by discussing possible treatment options, but also highlight that future research needs to further examine causal pathways and conceptual overlaps.", "doi": "10.1016/j.janxdis.2021.102454", "pmid": "34298237", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0887-6185(21)00101-8"}, {"db": "URL", "key": "https://osf.io/xb4ce/", "description": "Survey data"}], "notes": [], "created": "2021-08-05T07:07:49.825Z", "modified": "2021-11-18T09:14:45.531Z"}, {"entity": "publication", "iuid": "121e72cbf43f4f2fa38c2a5fb1a12997", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/121e72cbf43f4f2fa38c2a5fb1a12997.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/121e72cbf43f4f2fa38c2a5fb1a12997"}}, "title": "An international study on psychological coping during COVID-19: Towards a meaning-centered coping style.", "authors": [{"family": "Eisenbeck", "given": "Nikolett", "initials": "N"}, {"family": "Carreno", "given": "David F", "initials": "DF"}, {"family": "Wong", "given": "Paul T P", "initials": "PTP"}, {"family": "Hicks", "given": "Joshua A", "initials": "JA"}, {"family": "Mar\u00eda", "given": "Ru\u00edz-Ruano Garc\u00eda", "initials": "RG"}, {"family": "Puga", "given": "Jorge L", "initials": "JL"}, {"family": "Greville", "given": "James", "initials": "J"}, {"family": "Testoni", "given": "Ines", "initials": "I"}, {"family": "Biancalani", "given": "Gianmarco", "initials": "G"}, {"family": "L\u00f3pez", "given": "Ana Carla Cepeda", "initials": "ACC"}, {"family": "Villareal", "given": "Sof\u00eda", "initials": "S"}, {"family": "Enea", "given": "Violeta", "initials": "V"}, {"family": "Schulz-Quach", "given": "Christian", "initials": "C"}, {"family": "Jansen", "given": "Jonas", "initials": "J"}, {"family": "Sanchez-Ruiz", "given": "Maria-Jose", "initials": "M"}, {"family": "Y\u0131ld\u0131r\u0131m", "given": "Murat", "initials": "M"}, {"family": "Arslan", "given": "G\u00f6kmen", "initials": "G"}, {"family": "Cruz", "given": "Jos\u00e9 Fernando A", "initials": "JFA"}, {"family": "Sofia", "given": "Rui Manuel", "initials": "RM"}, {"family": "Ferreira", "given": "Maria Jos\u00e9", "initials": "MJ"}, {"family": "Ashraf", "given": "Farzana", "initials": "F"}, {"family": "W\u0105sowicz", "given": "Gra\u017cyna", "initials": "G"}, {"family": "Shalaby", "given": "Shahinaz M", "initials": "SM"}, {"family": "Amer", "given": "Reham A", "initials": "RA"}, {"family": "Yousfi", "given": "Hadda", "initials": "H"}, {"family": "Chukwuorji", "given": "JohnBosco Chika", "initials": "JC"}, {"family": "Guerra", "given": "Valeschka M", "initials": "VM"}, {"family": "Singh", "given": "Sandeep", "initials": "S"}, {"family": "Heintzelman", "given": "Samantha", "initials": "S"}, {"family": "Hutapea", "given": "Bonar", "initials": "B"}, {"family": "B\u00e9jaoui", "given": "Bouchara", "initials": "B"}, {"family": "Dash", "given": "Arobindu", "initials": "A"}, {"family": "Schlosser", "given": "Karoly Kornel", "initials": "KK"}, {"family": "Anniko", "given": "Malin K", "initials": "MK"}, {"family": "Rossa", "given": "Martin", "initials": "M"}, {"family": "Wongcharee", "given": "Hattaphan", "initials": "H"}, {"family": "Avsec", "given": "Andreja", "initials": "A"}, {"family": "Kocjan", "given": "Gaja Zager", "initials": "GZ"}, {"family": "Kav\u010di\u010d", "given": "Tina", "initials": "T"}, {"family": "Leontiev", "given": "Dmitry A", "initials": "DA"}, {"family": "Taranenko", "given": "Olga", "initials": "O"}, {"family": "Rasskazova", "given": "Elena", "initials": "E"}, {"family": "Maher", "given": "Elizabeth", "initials": "E"}, {"family": "Garc\u00eda-Montes", "given": "Jos\u00e9 Manuel", "initials": "JM"}], "type": "journal article", "published": "2021-07-14", "journal": {"title": "Int J Clin Health Psychol", "issn": "2174-0852", "issn-l": null, "volume": "22", "issue": "1", "pages": "100256"}, "abstract": "This study examined the role of different psychological coping mechanisms in mental and physical health during the initial phases of the COVID-19 crisis with an emphasis on meaning-centered coping.\r\n\r\nA total of 11,227 people from 30 countries across all continents participated in the study and completed measures of psychological distress (depression, stress, and anxiety), loneliness, well-being, and physical health, together with measures of problem-focused and emotion-focused coping, and a measure called the Meaning-centered Coping Scale (MCCS) that was developed in the present study. Validation analyses of the MCCS were performed in all countries, and data were assessed by multilevel modeling (MLM).\r\n\r\nThe MCCS showed a robust one-factor structure in 30 countries with good test-retest, concurrent and divergent validity results. MLM analyses showed mixed results regarding emotion and problem-focused coping strategies. However, the MCCS was the strongest positive predictor of physical and mental health among all coping strategies, independently of demographic characteristics and country-level variables.\r\n\r\nThe findings suggest that the MCCS is a valid measure to assess meaning-centered coping. The results also call for policies promoting effective coping to mitigate collective suffering during the pandemic.", "doi": "10.1016/j.ijchp.2021.100256", "pmid": "34429729", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1697-2600(21)00037-5"}, {"db": "pmc", "key": "PMC8355913"}], "notes": [], "created": "2021-08-27T09:36:53.616Z", "modified": "2021-11-18T09:03:19.676Z"}, {"entity": "publication", "iuid": "3dee1961748f40819892bf7be86fbd4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3dee1961748f40819892bf7be86fbd4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3dee1961748f40819892bf7be86fbd4d"}}, "title": "A pre/post analysis of the impact of the COVID-19 pandemic on the psychosocial work environment and recovery among healthcare workers in a large university hospital in Sweden.", "authors": [{"family": "Jonsdottir", "given": "Ingibj\u00f6rg H", "initials": "IH"}, {"family": "Degl'Innocenti", "given": "Alessio", "initials": "A"}, {"family": "Ahlstrom", "given": "Linda", "initials": "L"}, {"family": "Finizia", "given": "Caterina", "initials": "C"}, {"family": "Wijk", "given": "Helle", "initials": "H"}, {"family": "\u00c5kerstr\u00f6m", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-07-14", "journal": {"title": "J Public Health Res", "issn": "2279-9028", "issn-l": null}, "abstract": "The impact of the COVID-19 pandemic on workload, mental health, and well-being of healthcare workers, and particularly those on the front-line, has received considerable attention.\n\nWe surveyed hospital employees about their working environment during the pandemic and identified departments which were negatively affected in comparison to the pre-pandemic situation, as well as factors contributing to this. Setting and participants We surveyed all hospital employees at Sahlgrenska University Hospital, Sweden in September 2020 and compared results across departments and to the results of a large employee survey from October 2019.\n\nThe overall impact of the pandemic on perceived working conditions and possibility for recovery differed among departments. During the pandemic, healthcare workers working with COVID-19 patients reported poorer working environments than other employees. Factors significantly related to perception of work environment and recovery during the pandemic included worries of being infected, departmental transfer, and having insufficient access to personal protective equipment. Men reported better working conditions than women in all, but one item and higher age was related to better perceived working environment.\n\nOur results indicate that the pandemic differentially affects hospital departments and underscores the multifactorial nature of this topic. Contributing factors to poor perceived working environment could be addressed at times of high workload, such as during the pandemic, including providing appropriate support to managers, ensuring possibility for recovery during working hours, and acknowledging worries about infection. Young healthcare workers and staff who are relocated due to the pandemic warrant special attention.", "doi": "10.4081/jphr.2021.2329", "pmid": "34278769", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-05T11:12:31.477Z", "modified": "2021-08-05T11:12:31.489Z"}, {"entity": "publication", "iuid": "440e484854514d65875c54e966788b05", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/440e484854514d65875c54e966788b05.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/440e484854514d65875c54e966788b05"}}, "title": "Variant Analysis of SARS-CoV-2 Genomes from Belgian Military Personnel Engaged in Overseas Missions and Operations.", "authors": [{"family": "Pirnay", "given": "Jean-Paul", "initials": "JP", "orcid": "0000-0002-6863-5219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/57c49628604342ffae1231718cf6529e.json"}}, {"family": "Selhorst", "given": "Philippe", "initials": "P", "orcid": "0000-0002-4488-5790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a15ee083f17430aa249b4751f0b2002.json"}}, {"family": "Hong", "given": "Samuel L", "initials": "SL", "orcid": "0000-0001-6354-4943", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90a9fb0495604bb891f4fc786eca0a98.json"}}, {"family": "Cochez", "given": "Christel", "initials": "C"}, {"family": "Potter", "given": "Barney", "initials": "B"}, {"family": "Maes", "given": "Piet", "initials": "P"}, {"family": "Petrillo", "given": "Mauro", "initials": "M", "orcid": "0000-0002-6782-4704", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8183c35e5c7b40d1a7ea56a85521451b.json"}}, {"family": "Dudas", "given": "Gytis", "initials": "G", "orcid": "0000-0002-0227-4158", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/941f89c075f744219ea42f21be699871.json"}}, {"family": "Claes", "given": "Vincent", "initials": "V", "orcid": "0000-0001-6398-4009", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd75ac5e4f564a4f9feb651f1ecf4150.json"}}, {"family": "Van der Beken", "given": "Yolien", "initials": "Y"}, {"family": "Verbeken", "given": "Gilbert", "initials": "G"}, {"family": "Degueldre", "given": "Julie", "initials": "J"}, {"family": "Dellicour", "given": "Simon", "initials": "S", "orcid": "0000-0001-9558-1052", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35378313b42d4026a1deace84240c300.json"}}, {"family": "Cuypers", "given": "Lize", "initials": "L", "orcid": "0000-0002-9433-8752", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5fde6d7af1e406a83cc6284e285b473.json"}}, {"family": "T'Sas", "given": "France", "initials": "F"}, {"family": "Van den Eede", "given": "Guy", "initials": "G"}, {"family": "Verhasselt", "given": "Bruno", "initials": "B"}, {"family": "Weuts", "given": "Wouter", "initials": "W"}, {"family": "Smets", "given": "Cedric", "initials": "C"}, {"family": "Mertens", "given": "Jan", "initials": "J"}, {"family": "Geeraerts", "given": "Philippe", "initials": "P"}, {"family": "Ari\u00ebn", "given": "Kevin K", "initials": "KK"}, {"family": "Andr\u00e9", "given": "Emmanuel", "initials": "E"}, {"family": "Neirinckx", "given": "Pierre", "initials": "P"}, {"family": "Soentjens", "given": "Patrick", "initials": "P"}, {"family": "Baele", "given": "Guy", "initials": "G", "orcid": "0000-0002-1915-7732", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ed706bd4a744d8da6a2561880e98eba.json"}}], "type": "journal article", "published": "2021-07-13", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "7", "issn-l": "1999-4915"}, "abstract": "More than a year after the first identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as the causative agent of the 2019 coronavirus disease (COVID-19) in China, the emergence and spread of genomic variants of this virus through travel raise concerns regarding the introduction of lineages in previously unaffected regions, requiring adequate containment strategies. Concomitantly, such introductions fuel worries about a possible increase in transmissibility and disease severity, as well as a possible decrease in vaccine efficacy. Military personnel are frequently deployed on missions around the world. As part of a COVID-19 risk mitigation strategy, Belgian Armed Forces that engaged in missions and operations abroad were screened (7683 RT-qPCR tests), pre- and post-mission, for the presence of SARS-CoV-2, including the identification of viral lineages. Nine distinct viral genotypes were identified in soldiers returning from operations in Niger, the Democratic Republic of the Congo, Afghanistan, and Mali. The SARS-CoV-2 variants belonged to major clades 19B, 20A, and 20B (Nextstrain nomenclature), and included \"variant of interest\" B.1.525, \"variant under monitoring\" A.27, as well as lineages B.1.214, B.1, B.1.1.254, and A (pangolin nomenclature), some of which are internationally monitored due to the specific mutations they harbor. Through contact tracing and phylogenetic analysis, we show that isolation and testing policies implemented by the Belgian military command appear to have been successful in containing the influx and transmission of these distinct SARS-CoV-2 variants into military and civilian populations.", "doi": "10.3390/v13071359", "pmid": "34372565", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "v13071359"}], "notes": [], "created": "2021-08-11T14:32:26.858Z", "modified": "2021-08-11T14:33:04.232Z"}, {"entity": "publication", "iuid": "158d2c73662a4e4c9e3676dee6adb5e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/158d2c73662a4e4c9e3676dee6adb5e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/158d2c73662a4e4c9e3676dee6adb5e2"}}, "title": "Oxygen and Mortality in COVID-19 Pneumonia: A Comparative Analysis of Supplemental Oxygen Policies and Health Outcomes Across 26 Countries.", "authors": [{"family": "Mansab", "given": "Fatma", "initials": "F"}, {"family": "Donnelly", "given": "Harry", "initials": "H"}, {"family": "Kussner", "given": "Albrecht", "initials": "A"}, {"family": "Neil", "given": "James", "initials": "J"}, {"family": "Bhatti", "given": "Sohail", "initials": "S"}, {"family": "Goyal", "given": "Daniel K", "initials": "DK"}], "type": "journal article", "published": "2021-07-13", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "580585", "issn-l": "2296-2565"}, "abstract": "Introduction: Hypoxia is the main cause of morbidity and mortality in COVID-19. During the COVID-19 pandemic, some countries have reduced access to supplemental oxygen, whereas other nations have maintained and even improved access to supplemental oxygen. We examined whether variation in the nationally determined oxygen guidelines had any association with national mortality rates in COVID-19. Methods: Three independent investigators searched for, identified, and extracted the nationally recommended target oxygen levels for the commencement of oxygen in COVID-19 pneumonia from the 29 worst affected countries. Mortality estimates were calculated from three independent sources. We then applied both parametric (Pearson's R) and non-parametric (Kendall's Tau B) tests of bivariate association to determine the relationship between case fatality rate (CFR) and target SpO2, and also between potential confounders and CFR. Results: Of the 26 nations included, 15 had employed conservative oxygen strategies to manage COVID-19 pneumonia. Of them, Belgium, France, USA, Canada, China, Germany, Mexico, Spain, Sweden, and the UK guidelines advised commencing oxygen when oxygen saturations (SpO2) fell to 91% or less. A statistically significant correlation was found between SpO2 and CFR both parametrically (R = -0.53, P < 0.01) and non-parametrically (-0.474, P < 0.01). Conclusion: Our study highlights the disparity in oxygen provision for COVID-19 patients between the nations analysed. In those nations that pursued a conservative oxygen strategy, there was an association with higher national mortality rates. We discuss the potential reasons for such an association.", "doi": "10.3389/fpubh.2021.580585", "pmid": "34327182", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8313806"}], "notes": [], "created": "2021-08-04T17:04:55.055Z", "modified": "2021-08-04T17:05:02.692Z"}, {"entity": "publication", "iuid": "61e2ebaad09a477094041f730fbe213c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61e2ebaad09a477094041f730fbe213c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61e2ebaad09a477094041f730fbe213c"}}, "title": "Indications that Stockholm has reached herd immunity, given limited restrictions, against several variants of SARS-CoV-2", "authors": [{"family": "Carlsson", "given": "Marcus", "initials": "M", "orcid": "0000-0002-3761-9072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9492f80f98584a4c949a0114fb44ef71.json"}}, {"family": "S\u00f6derberg-Naucl\u00e9r", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-8955-3610", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f10026ba9a64bfea2fc49de969cdde9.json"}}], "type": "posted-content", "published": "2021-07-13", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.07.07.21260167", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-08-03T11:47:39.010Z", "modified": "2021-08-03T11:48:02.261Z"}, {"entity": "publication", "iuid": "8b75445e0d084e4690eb0ff93f85c84b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b75445e0d084e4690eb0ff93f85c84b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b75445e0d084e4690eb0ff93f85c84b"}}, "title": "COVID-19 Vaccines and Thrombosis-Roadblock or Dead-End Street?", "authors": [{"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Barh", "given": "Debmalya", "initials": "D", "orcid": "0000-0002-2557-7768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1de09014a90148069b6627b93ac71ea8.json"}}, {"family": "Uhal", "given": "Bruce D", "initials": "BD", "orcid": "0000-0002-5201-432X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d8004448df445bb86d5c733aa143e9b.json"}}, {"family": "Takayama", "given": "Kazuo", "initials": "K", "orcid": "0000-0002-1132-2457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de9286e534764113a02e6e51be237f86.json"}}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA", "orcid": "0000-0002-9519-6338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b9ca27af4d347c9b4097d3fd0ecf0bf.json"}}, {"family": "Abd El-Aziz", "given": "Tarek Mohamed", "initials": "TM", "orcid": "0000-0002-3441-9673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bd8ea28f1e24943b73f6d9e5d411aa3.json"}}, {"family": "Lal", "given": "Amos", "initials": "A", "orcid": "0000-0002-0021-2033", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf77b6a9233341f996b3ef515f41aa0f.json"}}, {"family": "Redwan", "given": "Elrashdy M", "initials": "EM", "orcid": "0000-0001-8246-0075", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf6f9cfd2f99436ea2eaecf2d83b07e9.json"}}, {"family": "Adadi", "given": "Parise", "initials": "P", "orcid": "0000-0003-4724-9463", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d2c862c9c1c4a1c8471708ae9628ef7.json"}}, {"family": "Chauhan", "given": "Gaurav", "initials": "G", "orcid": "0000-0002-5400-5638", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd1323f836244e91a37c69bb627cf0cd.json"}}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Azad", "given": "Gajendra Kumar", "initials": "GK", "orcid": "0000-0001-5478-526X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94c4f27a019d4cf2a9e459e6a914fa9c.json"}}, {"family": "Rezaei", "given": "Nima", "initials": "N", "orcid": "0000-0002-3836-1827", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/38c4c1dfbc464a1c8a08ab690568c6bd.json"}}, {"family": "Serrano-Aroca", "given": "\u00c1ngel", "initials": "\u00c1", "orcid": "0000-0002-9953-3848", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c8f520da33b429a8bc7eb19ff14f58d.json"}}, {"family": "Bazan", "given": "Nicolas G", "initials": "NG"}, {"family": "Hassan", "given": "Sk Sarif", "initials": "SS", "orcid": "0000-0003-4331-722X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c16068e54c442e580b4ba62905aa848.json"}}, {"family": "Panda", "given": "Pritam Kumar", "initials": "PK", "orcid": "0000-0003-4879-2302", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bbd0a928e33842a894bcb569549712c7.json"}}, {"family": "Pal Choudhury", "given": "Pabitra", "initials": "P"}, {"family": "Pizzol", "given": "Damiano", "initials": "D", "orcid": "0000-0003-4122-0774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b2b7ce8dc27462088eb836279b2d194.json"}}, {"family": "Kandimalla", "given": "Ramesh", "initials": "R", "orcid": "0000-0002-3313-4393", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5afbbf2e86e04041996b924b05b188f1.json"}}, {"family": "Baetas-da-Cruz", "given": "Wagner", "initials": "W"}, {"family": "Mishra", "given": "Yogendra Kumar", "initials": "YK", "orcid": "0000-0002-8786-9379", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4216dffbb5d04509b18c9f17fafee087.json"}}, {"family": "Palu", "given": "Giorgio", "initials": "G"}, {"family": "Brufsky", "given": "Adam M", "initials": "AM", "orcid": "0000-0001-8080-7960", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/869234cfbe6c42d5b0da85d4e9ee7464.json"}}, {"family": "Tambuwala", "given": "Murtaza M", "initials": "MM", "orcid": "0000-0001-8499-9891", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8ed708303c14ff8b1b3e9d1e60a4dfe.json"}}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN", "orcid": "0000-0002-4037-5857", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69478f3c84b7411fa4bb1c0043ce542b.json"}}], "type": "journal article", "published": "2021-07-13", "journal": {"title": "Biomolecules", "issn": "2218-273X", "volume": "11", "issue": "7", "issn-l": null}, "abstract": "Two adenovirus-based vaccines, ChAdOx1 nCoV-19 and Ad26.COV2.S, and two mRNA-based vaccines, BNT162b2 and mRNA.1273, have been approved by the European Medicines Agency (EMA), and are invaluable in preventing and reducing the incidence of coronavirus disease-2019 (COVID-19). Recent reports have pointed to thrombosis with associated thrombocytopenia as an adverse effect occurring at a low frequency in some individuals after vaccination. The causes of such events may be related to SARS-CoV-2 spike protein interactions with different C-type lectin receptors, heparan sulfate proteoglycans (HSPGs) and the CD147 receptor, or to different soluble splice variants of the spike protein, adenovirus vector interactions with the CD46 receptor or platelet factor 4 antibodies. Similar findings have been reported for several viral diseases after vaccine administration. In addition, immunological mechanisms elicited by viral vectors related to cellular delivery could play a relevant role in individuals with certain genetic backgrounds. Although rare, the potential COVID-19 vaccine-induced immune thrombotic thrombocytopenia (VITT) requires immediate validation, especially in risk groups, such as the elderly, chronic smokers, and individuals with pre-existing incidences of thrombocytopenia; and if necessary, a reformulation of existing vaccines.", "doi": "10.3390/biom11071020", "pmid": "34356644", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "biom11071020"}, {"db": "pmc", "key": "PMC8301964"}], "notes": [], "created": "2021-08-11T14:40:37.371Z", "modified": "2021-08-11T14:40:37.721Z"}, {"entity": "publication", "iuid": "36cf32d8e1f14ab3a9de2cef2a759e5f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/36cf32d8e1f14ab3a9de2cef2a759e5f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/36cf32d8e1f14ab3a9de2cef2a759e5f"}}, "title": "Blue Biotechnology: Computational Screening of Sarcophyton Cembranoid Diterpenes for SARS-CoV-2 Main Protease Inhibition.", "authors": [{"family": "Ibrahim", "given": "Mahmoud A A", "initials": "MAA", "orcid": "0000-0003-4819-2040", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/552195f5616e456b82fd45359b56f9c7.json"}}, {"family": "Abdelrahman", "given": "Alaa H M", "initials": "AHM", "orcid": "0000-0003-3527-0126", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89f2d2ac6ab343728c329fb71b4fa732.json"}}, {"family": "Atia", "given": "Mohamed A M", "initials": "MAM", "orcid": "0000-0003-2462-1269", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e973a0f11ca0459fa876c875fe3989cb.json"}}, {"family": "Mohamed", "given": "Tarik A", "initials": "TA", "orcid": "0000-0003-1639-3518", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69bfe5a2f846439dbea3d4d597546ec4.json"}}, {"family": "Moustafa", "given": "Mahmoud F", "initials": "MF"}, {"family": "Hakami", "given": "Abdulrahim R", "initials": "AR", "orcid": "0000-0003-2101-8800", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78ae225ce54745b489204cf1f3dd57c4.json"}}, {"family": "Khalifa", "given": "Shaden A M", "initials": "SAM"}, {"family": "Alhumaydhi", "given": "Fahad A", "initials": "FA", "orcid": "0000-0002-0151-8309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/575d134a229546749190bad9e2018ea1.json"}}, {"family": "Alrumaihi", "given": "Faris", "initials": "F", "orcid": "0000-0002-0850-5500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b60452d537bd43e1a01af011e03c5ea5.json"}}, {"family": "Abidi", "given": "Syed Hani", "initials": "SH", "orcid": "0000-0001-9497-0902", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/401fcf2d494a4afaafec85336c009b6b.json"}}, {"family": "Allemailem", "given": "Khaled S", "initials": "KS", "orcid": "0000-0002-6486-9835", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d53444ec5a8f4b15b4d1e455a9578733.json"}}, {"family": "Efferth", "given": "Thomas", "initials": "T"}, {"family": "Soliman", "given": "Mahmoud E", "initials": "ME"}, {"family": "Par\u00e9", "given": "Paul W", "initials": "PW", "orcid": "0000-0003-1644-723X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ac0f276b143475db0df390f50c8658b.json"}}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR", "orcid": "0000-0002-2519-6690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d35dc868deec44a69caa5ed9a65c15ce.json"}}, {"family": "Hegazy", "given": "Mohamed-Elamir F", "initials": "MF", "orcid": "0000-0002-0343-4969", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/efe074c3fdcc4601ba363cbdb84595bf.json"}}], "type": "journal article", "published": "2021-07-13", "journal": {"title": "Mar Drugs", "issn": "1660-3397", "volume": "19", "issue": "7", "issn-l": null}, "abstract": "The coronavirus pandemic has affected more than 150 million people, while over 3.25 million people have died from the coronavirus disease 2019 (COVID-19). As there are no established therapies for COVID-19 treatment, drugs that inhibit viral replication are a promising target; specifically, the main protease (Mpro) that process CoV-encoded polyproteins serves as an Achilles heel for assembly of replication-transcription machinery as well as down-stream viral replication. In the search for potential antiviral drugs that target Mpro, a series of cembranoid diterpenes from the biologically active soft-coral genus Sarcophyton have been examined as SARS-CoV-2 Mpro inhibitors. Over 360 metabolites from the genus were screened using molecular docking calculations. Promising diterpenes were further characterized by molecular dynamics (MD) simulations based on molecular mechanics-generalized Born surface area (MM-GBSA) binding energy calculations. According to in silico calculations, five cembranoid diterpenes manifested adequate binding affinities as Mpro inhibitors with \u0394Gbinding < -33.0 kcal/mol. Binding energy and structural analyses of the most potent Sarcophyton inhibitor, bislatumlide A (340), was compared to darunavir, an HIV protease inhibitor that has been recently subjected to clinical-trial as an anti-COVID-19 drug. In silico analysis indicates that 340 has a higher binding affinity against Mpro than darunavir with \u0394Gbinding values of -43.8 and -34.8 kcal/mol, respectively throughout 100 ns MD simulations. Drug-likeness calculations revealed robust bioavailability and protein-protein interactions were identified for 340; biochemical signaling genes included ACE, MAPK14 and ESR1 as identified based on a STRING database. Pathway enrichment analysis combined with reactome mining revealed that 340 has the capability to re-modulate the p38 MAPK pathway hijacked by SARS-CoV-2 and antagonize injurious effects. These findings justify further in vivo and in vitro testing of 340 as an antiviral agent against SARS-CoV-2.", "doi": "10.3390/md19070391", "pmid": "34356816", "labels": {"Category: Biochemistry": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "md19070391"}, {"db": "pmc", "key": "PMC8308023"}], "notes": [], "created": "2021-08-11T14:39:16.626Z", "modified": "2021-08-11T14:39:16.895Z"}, {"entity": "publication", "iuid": "bb24d0e5e1c24a38992eb445246d9f76", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb24d0e5e1c24a38992eb445246d9f76.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb24d0e5e1c24a38992eb445246d9f76"}}, "title": "Epidemiological characteristics and initial spatiotemporal visualisation of COVID-19 in a major city in the Middle East.", "authors": [{"family": "MohammadEbrahimi", "given": "Shahab", "initials": "S", "orcid": "0000-0002-1494-1544", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bdc10ef3b2e54ae18547877efaf5c000.json"}}, {"family": "Mohammadi", "given": "Alireza", "initials": "A", "orcid": "0000-0002-3327-0942", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f5101616a2d41468b9a706f743f49b3.json"}}, {"family": "Bergquist", "given": "Robert", "initials": "R", "orcid": "0000-0002-0190-1084", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78ef78e2b8334cb99d848a429434cfb5.json"}}, {"family": "Dolatkhah", "given": "Fatemeh", "initials": "F", "orcid": "0000-0002-8342-6618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77db8d4308024e9e86b854718b579739.json"}}, {"family": "Olia", "given": "Mahsa", "initials": "M", "orcid": "0000-0002-5013-7000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e84399127f9b4ba48b884b3ca9e9e4dd.json"}}, {"family": "Tavakolian", "given": "Ayoub", "initials": "A", "orcid": "0000-0002-4884-8524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69886ea0ac0547e0b85f16b91b3d3f41.json"}}, {"family": "Pishgar", "given": "Elahe", "initials": "E", "orcid": "0000-0001-7217-2598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac8cf4f85ea34ad297a6343ef7bc4044.json"}}, {"family": "Kiani", "given": "Behzad", "initials": "B", "orcid": "0000-0002-8816-328X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c30601593bd54510866e077ade6765d0.json"}}], "type": "journal article", "published": "2021-07-12", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "1373"}, "abstract": "The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) emerged initially in China in December 2019 causing the COVID-19 disease, which quickly spread worldwide. Iran was one of the first countries outside China to be affected in a major way and is now under the spell of a fourth wave. This study aims to investigate the epidemiological characteristics of COVID-19 cases in north-eastern Iran through mapping the spatiotemporal trend of the disease.\r\n\r\nThe study comprises data of 4000 patients diagnosed by laboratory assays or clinical investigation from the beginning of the disease on Feb 14, 2020, until May 11, 2020. Epidemiological features and spatiotemporal trends of the disease in the study area were explored by classical statistical approaches and Geographic Information Systems.\r\n\r\nMost common symptoms were dyspnoea (69.4%), cough (59.4%), fever (54.4%) and weakness (19.5%). Approximately 82% of those who did not survive suffered from dyspnoea. The highest Case Fatality Rate (CFR) was related to those with cardiovascular disease (27.9%) and/or diabetes (18.1%). Old age (\u226560 years) was associated with an almost five-fold increased CFR. Odds Ratio (OR) showed malignancy (3.8), nervous diseases (2.2), and respiratory diseases (2.2) to be significantly associated with increased CFR with developments, such as hospitalization at the ICU (2.9) and LOS (1.1) also having high correlations. Furthermore, spatial analyses revealed a geographical pattern in terms of both incidence and mortality rates, with COVID-19 first being observed in suburban areas from where the disease swiftly spread into downtown reaching a peak between 25 February to 06 March (4 incidences per km2). Mortality peaked 3 weeks later after which the infection gradually decreased. Out of patients investigated by the spatiotemporal approach (n = 727), 205 (28.2%) did not survive and 66.8% of them were men.\r\n\r\nOlder adults and people with severe co-morbidities were at higher risk for developing serious complications due to COVID-19. Applying spatiotemporal methods to identify the transmission trends and high-risk areas can rapidly be documented, thereby assisting policymakers in designing and implementing tailored interventions to control and prevent not only COVID-19 but also other rapidly spreading epidemics/pandemics.", "doi": "10.1186/s12889-021-11326-2", "pmid": "34247616", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11326-2"}, {"db": "pmc", "key": "PMC8272989"}], "notes": [], "created": "2021-08-06T07:49:43.922Z", "modified": "2021-11-18T08:58:58.477Z"}, {"entity": "publication", "iuid": "38586f75de7947afa759f06f240e3a9b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38586f75de7947afa759f06f240e3a9b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38586f75de7947afa759f06f240e3a9b"}}, "title": "Comparison of online learning designs during the COVID-19 pandemic within bioinformatics courses in higher education.", "authors": [{"family": "Abrahamsson", "given": "Sanna", "initials": "S"}, {"family": "D\u00e1vila L\u00f3pez", "given": "Marcela", "initials": "M"}], "type": "journal article", "published": "2021-07-12", "journal": {"title": "Bioinformatics", "issn": "1367-4811", "volume": "37", "issue": "Suppl_1", "pages": "i9-i15", "issn-l": null}, "abstract": "Due to the worldwide COVID-19 pandemic, new strategies had to be adopted to move from classroom-based education to online education, in a very short time. The lack of time to set up these strategies, hindered a proper design of online instructions and delivery of knowledge. Bioinformatics-related training and other onsite practical education, tend to rely on extensive practice, where students and instructors have a face-to-face interaction to improve the learning outcome. For these courses to maintain their high quality when adapted as online courses, different designs need to be tested and the students' perceptions need to be heard.\n\nThis study focuses on short bioinformatics-related courses for graduate students at the University of Gothenburg, Sweden, which were originally developed for onsite training. Once adapted as online courses, several modifications in their design were tested to obtain the best fitting learning strategy for the students. To improve the online learning experience, we propose a combination of: (i) short synchronized sessions, (ii) extended time for own and group practical work, (iii) recorded live lectures and (iv) increased opportunities for feedback in several formats.\n\nSupplementary data are available at Bioinformatics online.", "doi": "10.1093/bioinformatics/btab304", "pmid": "34252967", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "6319705"}], "notes": [], "created": "2021-08-06T07:36:14.851Z", "modified": "2021-08-06T07:48:18.065Z"}, {"entity": "publication", "iuid": "d2b62737826f4a37af9872b0e5c8caf6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d2b62737826f4a37af9872b0e5c8caf6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d2b62737826f4a37af9872b0e5c8caf6"}}, "title": "Study of SARS-CoV-2 transmission in urban environment by questionnaire and modeling for sustainable risk control.", "authors": [{"family": "Yu", "given": "Han", "initials": "H"}, {"family": "Ye", "given": "Xuying", "initials": "X"}, {"family": "Zhang", "given": "Minying", "initials": "M"}, {"family": "Zhang", "given": "Fenghao", "initials": "F"}, {"family": "Li", "given": "Yao", "initials": "Y"}, {"family": "Pan", "given": "Suxun", "initials": "S"}, {"family": "Li", "given": "Yuanling", "initials": "Y"}, {"family": "Yu", "given": "Hongbing", "initials": "H"}, {"family": "Lu", "given": "Chengzhi", "initials": "C"}], "type": "journal article", "published": "2021-07-10", "journal": {"title": "J Hazard Mater", "issn": "1873-3336", "issn-l": null, "volume": "420", "issue": null, "pages": "126621"}, "abstract": "Caused by SARS-CoV-2, COVID-19 has become a severe threaten to society and human health, its epidemic control emerges as long-term issue. A sustainable epidemic and environmental transmission risk control (SEERC) in urban area is urgently needed. This work aims to conduct a new investigation on the transmission risk of SARS-COV-2 as virus/hazardous material through various environmental medias, routes and regions in the entirely urban area for guiding the SEERC. Specifically, 5 routes in 28 regions (totally 140 scenarios) are considered. For a new perspective, the risk evaluation is conducted by the quantification of frontline medicals staffs' valuable experience in this work. 207 specialists responsible for the treatment of over 9000 infected patients are involved. The result showed that degree of risk was in the order of breath>contact-to-object>contact-to-human>intake>unknown. The modeling suggested source control as the prior measure for epidemic control. The combination of source control & mask wearing showed high efficiency in SEERC. The homeworking policy needed to cooperate with activity limitation to perform its efficiency. Subsequently, a new plan for SEERC was discussed. This work delivered significant information to researchers and decision makers for the further development of sustainable control for SARS-COV-2 spreading and COVID-19 epidemic.", "doi": "10.1016/j.jhazmat.2021.126621", "pmid": "34274804", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0304-3894(21)01586-7"}, {"db": "pmc", "key": "PMC8270745"}], "notes": [], "created": "2021-08-05T11:14:26.544Z", "modified": "2021-11-18T08:56:25.353Z"}, {"entity": "publication", "iuid": "f3652b085fec4a67a2878ce58ccfbbe6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f3652b085fec4a67a2878ce58ccfbbe6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f3652b085fec4a67a2878ce58ccfbbe6"}}, "title": "The one-sided explanations of a multifactorial coronavirus disease.", "authors": [{"family": "Ros\u00e9n", "given": "M\u00e5ns", "initials": "M", "orcid": "0000-0001-5295-0014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d544032f8b1c4fa1991916eda98aa5b9.json"}}, {"family": "Stenbeck", "given": "David", "initials": "D"}, {"family": "Stenbeck", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-07-09", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "14034948211026540", "issn-l": "1403-4948"}, "abstract": "Short-term interventions to suppress COVID-19 completely dominate the public, political and even the professional discussion on what explains observed differences in mortality and morbidity across countries. This leads to an exaggerated view of what such measures can accomplish. Factors such as housing and social conditions as well as travel patterns are equally important but neglected aspects of the COVID-19 development. A multifactorial disease needs a multivariate analytical approach.", "doi": "10.1177/14034948211026540", "pmid": "34240648", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:59:17.642Z", "modified": "2021-08-06T07:59:17.682Z"}, {"entity": "publication", "iuid": "19f38ab941cf4bbfb971c9e6fab34798", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19f38ab941cf4bbfb971c9e6fab34798.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19f38ab941cf4bbfb971c9e6fab34798"}}, "title": "The good, the bad and the ugly of children\u00b4s screen time during the COVID-19 pandemic.", "authors": [{"family": "Korhonen", "given": "Laura", "initials": "L", "orcid": "0000-0002-1837-5930", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a549aa5146734b40bd08f5f48a0ab366.json"}}], "type": "editorial", "published": "2021-07-09", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253"}, "abstract": null, "doi": "10.1111/apa.16012", "pmid": "34245034", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:52:35.947Z", "modified": "2021-08-06T07:56:46.829Z"}, {"entity": "publication", "iuid": "b97b058da45f40cd9d8bf05fd0f5bda9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b97b058da45f40cd9d8bf05fd0f5bda9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b97b058da45f40cd9d8bf05fd0f5bda9"}}, "title": "Self-Exclusion from Gambling-A Measure of COVID-19 Impact on Gambling in a Highly Online-Based Gambling Market?", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A", "orcid": "0000-0002-5800-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec14ecdcc0654d8ea864f64ce195752b.json"}}, {"family": "Widinghoff", "given": "Carolina", "initials": "C"}, {"family": "Berge", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2021-07-09", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "14", "pages": null}, "abstract": "The COVID-19 pandemic, and related changes of the gambling market, have been suspected to affect the risk of problem gambling. Despite media attention and political concern with this risk, study findings hitherto have been mixed. Voluntary self-exclusion from gambling was introduced on a national level in Sweden as a harm reduction tool in 2019, and this self-exclusion service in Sweden is a rare example of such an official, nationwide, multi-operator system. The present study aimed to evaluate whether short-term self-exclusion patterns were affected by different phases of COVID-19-related impacts on gambling markets in 2020. During the lock-down of sports in the spring months of 2020, three-month self-exclusion was unaffected, and one-month self-exclusion appeared to increase, though not more than in a recent period prior to COVID-19. Despite large differences in sports betting practices between women and men, self-exclusion patterns during COVID-19 were not apparently gender-specific. Altogether, self-exclusion from gambling, to date, does not appear to be affected by COVID-19-related changes in society, in contrast with beliefs about such changes producing greater help-seeking behavior in gamblers. Limitations are discussed, including the fact that in a recently introduced system, seasonality aspects and the autocorrelated nature of the data made substantial statistical measures unfeasible.", "doi": "10.3390/ijerph18147367", "pmid": "34299817", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph18147367"}, {"db": "pmc", "key": "PMC8305751"}], "notes": [], "created": "2021-08-05T07:07:30.294Z", "modified": "2021-11-18T08:54:37.444Z"}, {"entity": "publication", "iuid": "0bc0e45ee27f43388eea0bea6188ba6e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0bc0e45ee27f43388eea0bea6188ba6e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0bc0e45ee27f43388eea0bea6188ba6e"}}, "title": "Schools closed due to COVID-19 pandemic can be reopened early and safely.", "authors": [{"family": "Milerad", "given": "Josef", "initials": "J", "orcid": "0000-0003-1775-4602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/57d6b75491ed49a18ada88ae9d46e0a6.json"}}], "type": "editorial", "published": "2021-07-09", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253"}, "abstract": null, "doi": "10.1111/apa.16010", "pmid": "34245052", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:51:14.722Z", "modified": "2021-08-06T07:56:22.741Z"}, {"entity": "publication", "iuid": "3182957ca98c4962886b0eda0c9205a3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3182957ca98c4962886b0eda0c9205a3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3182957ca98c4962886b0eda0c9205a3"}}, "title": "Gender-specific estimates of sleep problems during the COVID-19 pandemic: Systematic review and meta-analysis.", "authors": [{"family": "Alimoradi", "given": "Zainab", "initials": "Z"}, {"family": "Gozal", "given": "David", "initials": "D"}, {"family": "Tsang", "given": "Hector W H", "initials": "HWH"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A", "orcid": "0000-0002-0433-0619", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07e3a9fa06004152bb4f194f4d2d1d8c.json"}}, {"family": "Ohayon", "given": "Maurice M", "initials": "MM"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-07-09", "journal": {"title": "J Sleep Res", "issn": "1365-2869", "issn-l": "0962-1105", "volume": null, "issue": null, "pages": "e13432"}, "abstract": "The outbreak of the novel coronavirus disease 2019 (COVID-19) changed lifestyles worldwide and subsequently induced individuals' sleep problems. Sleep problems have been demonstrated by scattered evidence among the current literature on COVID-19; however, little is known regarding the synthesised prevalence of sleep problems (i.e. insomnia symptoms and poor sleep quality) for males and females separately. The present systematic review and meta-analysis aimed to answer the important question regarding prevalence of sleep problems during the COVID-19 outbreak period between genders. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline and Newcastle-Ottawa Scale checklist, relevant studies with satisfactory methodological quality searched for in five academic databases (Scopus, PubMed Central, ProQuest, Web of Science , and EMBASE) were included and analysed. The protocol of the project was registered in the International Prospective Register of Systematic Reviews (PROSPERO; identification code CRD42020181644). A total of 54 papers (N = 67,722) in the female subgroup and 45 papers (N = 45,718) in the male subgroup were pooled in the meta-analysis. The corrected pooled estimated prevalence of sleep problems was 24% (95% confidence interval [CI] 19%-29%) for female participants and 27% (95% CI 24%-30%) for male participants. Although in both gender subgroups, patients with COVID-19, health professionals and general population showed the highest prevalence of sleep problems, it did not reach statistical significance. Based on multivariable meta-regression, both gender groups had higher prevalence of sleep problems during the lockdown period. Therefore, healthcare providers should pay attention to the sleep problems and take appropriate preventive action.", "doi": "10.1111/jsr.13432", "pmid": "34245055", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:50:54.687Z", "modified": "2021-11-18T08:51:42.937Z"}, {"entity": "publication", "iuid": "823bb9f54aa14eff88ccb2d6880fa2d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/823bb9f54aa14eff88ccb2d6880fa2d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/823bb9f54aa14eff88ccb2d6880fa2d7"}}, "title": "Development and validation of a tool to appraise guidelines on SARS-CoV-2 infection control strategies in healthcare workers.", "authors": [{"family": "Subramaniam", "given": "Ashwin", "initials": "A"}, {"family": "Ponnapa Reddy", "given": "Mallikarjuna", "initials": "M"}, {"family": "Kadam", "given": "Umesh", "initials": "U"}, {"family": "Zubarev", "given": "Alexander", "initials": "A"}, {"family": "Lim", "given": "Zheng", "initials": "Z"}, {"family": "Anstey", "given": "Chris", "initials": "C"}, {"family": "Bihari", "given": "Shailesh", "initials": "S"}, {"family": "Haji", "given": "Jumana", "initials": "J"}, {"family": "Luo", "given": "Jinghang", "initials": "J"}, {"family": "Mitra", "given": "Saikat", "initials": "S"}, {"family": "Ramanathan", "given": "Kollengode", "initials": "K"}, {"family": "Rajamani", "given": "Arvind", "initials": "A"}, {"family": "Rubulotta", "given": "Francesca", "initials": "F"}, {"family": "Svensk", "given": "Erik", "initials": "E"}, {"family": "Shekar", "given": "Kiran", "initials": "K"}], "type": "journal article", "published": "2021-07-09", "journal": {"title": "Aust Crit Care", "issn": "1036-7314", "issn-l": null}, "abstract": "Clinical guidelines on infection control strategies in healthcare workers (HCWs) play an important role in protecting them during the severe acute respiratory syndrome coronavirus 2 pandemic. Poorly constructed guidelines that are incomprehensive and/or ambiguous may compromise HCWs' safety.\n\nThe objective of this study was to develop and validate a tool to appraise guidelines on infection control strategies in HCWs based on the guidelines published early in the coronavirus disease 2019 pandemic.\n\nA three-stage, web-based, Delphi consensus-building process among a panel of diverse HCWs and healthcare managers was performed. The tool was validated by appraising 40 international, specialty-specific, and procedure-specific guidelines along with national guidelines from countries with a wide range of gross national income.\n\nOverall consensus (\u226575%) was reached at the end of three rounds for all six domains included in the tool. The Delphi panel recommended an ideal infection control guideline should encompass six domains: general characteristics (domain 1), engineering recommendations (domain 2), personal protective equipment (PPE) use (domain 3), and administrative aspects (domain 4-6) of infection control. The appraisal tool performed well across the six domains, and the inter-rater agreement was excellent for the 40 guidelines. All included guidelines performed relatively better in domains 1-3 than in domains 4-6, and this was more evident in guidelines originating from lower income countries.\n\nThe guideline appraisal tool was robust and easy to use. Engineering recommendations aspects of infection control, administrative measures that promote optimal PPE use, and HCW wellbeing were generally lacking in assessed guidelines. This tool may enable health systems to adopt high-quality HCW infection control guidelines during the severe acute respiratory syndrome coronavirus 2 pandemic and may also provide a framework for future guideline development.", "doi": "10.1016/j.aucc.2021.06.015", "pmid": "34404579", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1036-7314(21)00109-0"}], "notes": [], "created": "2021-08-20T12:22:10.265Z", "modified": "2021-08-20T12:22:34.716Z"}, {"entity": "publication", "iuid": "75228cad4a604941871dc8aa3b32d156", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/75228cad4a604941871dc8aa3b32d156.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/75228cad4a604941871dc8aa3b32d156"}}, "title": "Correction to 'Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy'.", "authors": [{"family": "Wacker", "given": "Anna", "initials": "A"}, {"family": "Weigand", "given": "Julia E", "initials": "JE", "orcid": "0000-0003-4247-1348", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5229ec08ce9242c19049804ff8a77085.json"}}, {"family": "Akabayov", "given": "Sabine R", "initials": "SR"}, {"family": "Altincekic", "given": "Nadide", "initials": "N"}, {"family": "Bains", "given": "Jasleen Kaur", "initials": "JK"}, {"family": "Banijamali", "given": "Elnaz", "initials": "E"}, {"family": "Binas", "given": "Oliver", "initials": "O"}, {"family": "Castillo-Martinez", "given": "Jesus", "initials": "J"}, {"family": "Cetiner", "given": "Erhan", "initials": "E"}, {"family": "Ceylan", "given": "Bet\u00fcl", "initials": "B"}, {"family": "Chiu", "given": "Liang-Yuan", "initials": "LY"}, {"family": "Davila-Calderon", "given": "Jesse", "initials": "J"}, {"family": "Dhamotharan", "given": "Karthikeyan", "initials": "K"}, {"family": "Duchardt-Ferner", "given": "Elke", "initials": "E"}, {"family": "Ferner", "given": "Jan", "initials": "J"}, {"family": "Frydman", "given": "Lucio", "initials": "L"}, {"family": "F\u00fcrtig", "given": "Boris", "initials": "B", "orcid": "0000-0001-6443-7656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5e0849167334290a5bd6691644783bf.json"}}, {"family": "Gallego", "given": "Jos\u00e9", "initials": "J", "orcid": "0000-0002-0627-6927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b188371610a46858542181b11863966.json"}}, {"family": "Gr\u00fcn", "given": "J Tassilo", "initials": "JT"}, {"family": "Hacker", "given": "Carolin", "initials": "C"}, {"family": "Haddad", "given": "Christina", "initials": "C"}, {"family": "H\u00e4hnke", "given": "Martin", "initials": "M"}, {"family": "Hengesbach", "given": "Martin", "initials": "M", "orcid": "0000-0001-9414-1602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa75083441294b4f8fe68b1a42fee601.json"}}, {"family": "Hiller", "given": "Fabian", "initials": "F"}, {"family": "Hohmann", "given": "Katharina F", "initials": "KF"}, {"family": "Hymon", "given": "Daniel", "initials": "D"}, {"family": "de Jesus", "given": "Vanessa", "initials": "V"}, {"family": "Jonker", "given": "Henry", "initials": "H"}, {"family": "Keller", "given": "Heiko", "initials": "H"}, {"family": "Knezic", "given": "Bozana", "initials": "B"}, {"family": "Landgraf", "given": "Tom", "initials": "T"}, {"family": "L\u00f6hr", "given": "Frank", "initials": "F"}, {"family": "Luo", "given": "Le", "initials": "L"}, {"family": "Mertinkus", "given": "Klara R", "initials": "KR"}, {"family": "Muhs", "given": "Christina", "initials": "C"}, {"family": "Novakovic", "given": "Mihajlo", "initials": "M"}, {"family": "Oxenfarth", "given": "Andreas", "initials": "A"}, {"family": "Palomino-Sch\u00e4tzlein", "given": "Martina", "initials": "M"}, {"family": "Petzold", "given": "Katja", "initials": "K"}, {"family": "Peter", "given": "Stephen A", "initials": "SA"}, {"family": "Pyper", "given": "Dennis J", "initials": "DJ"}, {"family": "Qureshi", "given": "Nusrat S", "initials": "NS"}, {"family": "Riad", "given": "Magdalena", "initials": "M"}, {"family": "Richter", "given": "Christian", "initials": "C"}, {"family": "Saxena", "given": "Krishna", "initials": "K"}, {"family": "Schamber", "given": "Tatjana", "initials": "T"}, {"family": "Scherf", "given": "Tali", "initials": "T"}, {"family": "Schlagnitweit", "given": "Judith", "initials": "J"}, {"family": "Schlundt", "given": "Andreas", "initials": "A", "orcid": "0000-0003-2254-7560", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/662b48aa496e4109aab02871f6b1d43d.json"}}, {"family": "Schnieders", "given": "Robbin", "initials": "R"}, {"family": "Schwalbe", "given": "Harald", "initials": "H", "orcid": "0000-0001-5693-7909", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32641f04b8504ac493d46947e87e4f59.json"}}, {"family": "Simba-Lahuasi", "given": "Alvaro", "initials": "A"}, {"family": "Sreeramulu", "given": "Sridhar", "initials": "S"}, {"family": "Stirnal", "given": "Elke", "initials": "E"}, {"family": "Sudakov", "given": "Alexey", "initials": "A"}, {"family": "Tants", "given": "Jan-Niklas", "initials": "JN"}, {"family": "Tolbert", "given": "Blanton S", "initials": "BS"}, {"family": "V\u00f6gele", "given": "Jennifer", "initials": "J"}, {"family": "Wei\u00df", "given": "Lena", "initials": "L"}, {"family": "Wirmer-Bartoschek", "given": "Julia", "initials": "J"}, {"family": "Wirtz Martin", "given": "Maria A", "initials": "MA"}, {"family": "W\u00f6hnert", "given": "Jens", "initials": "J", "orcid": "0000-0001-7193-401X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/611eebfc08f54e20b4dc9b881da010b8.json"}}, {"family": "Zetzsche", "given": "Heidi", "initials": "H"}], "type": "published erratum", "published": "2021-07-09", "journal": {"title": "Nucleic Acids Res", "issn": "1362-4962", "volume": "49", "issue": "12", "pages": "7204-7205", "issn-l": "0305-1048"}, "abstract": null, "doi": "10.1093/nar/gkab568", "pmid": "34161581", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8266613"}, {"db": "pii", "key": "6308495"}], "notes": [], "created": "2021-06-28T18:17:42.332Z", "modified": "2023-06-19T15:30:50.411Z"}, {"entity": "publication", "iuid": "d079fcc4919b45aba6636d41ad1bfaa8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d079fcc4919b45aba6636d41ad1bfaa8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d079fcc4919b45aba6636d41ad1bfaa8"}}, "title": "Baricitinib reduces 30-day mortality in older adults with moderate-to-severe COVID-19 pneumonia.", "authors": [{"family": "Abizanda", "given": "Pedro", "initials": "P"}, {"family": "Calbo Mayo", "given": "Juan Mar\u00eda", "initials": "JM"}, {"family": "Mas Romero", "given": "Marta", "initials": "M"}, {"family": "Cort\u00e9s Zamora", "given": "Elisa Bel\u00e9n", "initials": "EB"}, {"family": "Tabernero Sahuquillo", "given": "Mar\u00eda Teresa", "initials": "MT"}, {"family": "Romero Rizos", "given": "Luis", "initials": "L"}, {"family": "S\u00e1nchez-Jurado", "given": "Pedro Manuel", "initials": "PM"}, {"family": "S\u00e1nchez-Nievas", "given": "Gin\u00e9s", "initials": "G"}, {"family": "Campayo Escolano", "given": "Carlos", "initials": "C"}, {"family": "Ochoa Serrano", "given": "Alba", "initials": "A"}, {"family": "S\u00e1nchez-Flor Alfaro", "given": "Victoria", "initials": "V"}, {"family": "L\u00f3pez Bru", "given": "Rita", "initials": "R"}, {"family": "G\u00f3mez Ballesteros", "given": "Cristina", "initials": "C"}, {"family": "Caldevilla Bernardo", "given": "David", "initials": "D"}, {"family": "Callejas Gonz\u00e1lez", "given": "Francisco Javier", "initials": "FJ"}, {"family": "Andr\u00e9s-Pretel", "given": "Fernando", "initials": "F"}, {"family": "Lauschke", "given": "Volker Martin", "initials": "VM"}, {"family": "Stebbing", "given": "Justin", "initials": "J"}], "type": "journal article", "published": "2021-07-08", "journal": {"title": "J Am Geriatr Soc", "issn": "0002-8614", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Older adults are at the highest risk of severe disease and death due to COVID-19. Randomized data have shown that baricitinib improves outcomes in these patients, but focused stratified analyses of geriatric cohorts are lacking. Our objective was to analyze the efficacy of baricitinib in older adults with COVID-19 moderate-to-severe pneumonia.\r\n\r\nThis is a propensity score [PS]-matched retrospective cohort study. Patients from the COVID-AGE and Alba-Score cohorts, hospitalized for moderate-to-severe COVID-19 pneumonia, were categorized in two age brackets of age <70 years old (86 with baricitinib and 86 PS-matched controls) or \u226570 years old (78 on baricitinib and 78 PS-matched controls). Thirty-day mortality rates were analyzed with Kaplan-Meier and Cox proportional hazard models.\r\n\r\nMean age was 79.1 for those \u226570 years and 58.9 for those <70. Exactly 29.6% were female. Treatment with baricitinib resulted in a significant reduction in death from any cause by 48% in patients aged 70 or older, an 18.5% reduction in 30-day absolute mortality risk (n/N: 16/78 [20.5%] baricitinib, 30/78 [38.5%] in PS-matched controls, p < 0.001) and a lower 30-day adjusted fatality rate (HR 0.21; 95% CI 0.09-0.47; p < 0.001). Beneficial effects on mortality were also observed in the age group <70 (8.1% reduction in 30-day absolute mortality risk; HR 0.14; 95% CI 0.03-0.64; p = 0.011).\r\n\r\nBaricitinib is associated with an absolute mortality risk reduction of 18.5% in adults older than 70 years hospitalized with COVID-19 pneumonia.", "doi": "10.1111/jgs.17357", "pmid": "34235720", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-06T08:21:28.943Z", "modified": "2021-08-23T14:38:39.781Z"}, {"entity": "publication", "iuid": "f36f197d53a64a43902196bf0722814e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f36f197d53a64a43902196bf0722814e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f36f197d53a64a43902196bf0722814e"}}, "title": "Swedish nationwide time series analysis of influenza and suicide deaths from 1910 to 1978.", "authors": [{"family": "R\u00fcck", "given": "Christian", "initials": "C", "orcid": "0000-0002-8742-0168", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1183965f649f4bf08e86186f5ec30519.json"}}, {"family": "Mataix-Cols", "given": "David", "initials": "D"}, {"family": "Malki", "given": "Kinda", "initials": "K"}, {"family": "Adler", "given": "Mats", "initials": "M"}, {"family": "Flygare", "given": "Oskar", "initials": "O", "orcid": "0000-0002-2017-3940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b7ed40871394a0d993b094b809a1e70.json"}}, {"family": "Runeson", "given": "Bo", "initials": "B"}, {"family": "Sidorchuk", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-07-07", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "7", "pages": "e049302"}, "abstract": "There is concern that the COVID-19 pandemic will be associated with an increase in suicides, but evidence supporting a link between pandemics and suicide is limited. Using data from the three influenza pandemics of the 20th century, we aimed to investigate whether an association exists between influenza deaths and suicide deaths.\r\n\r\nTime series analysis.\r\n\r\nSweden.\r\n\r\nDeaths from influenza and suicides extracted from the Statistical Yearbook of Sweden for 1910-1978, covering three pandemics (the Spanish influenza, the Asian influenza and the Hong Kong influenza).\r\n\r\nAnnual suicide rates in Sweden among the whole population, men and women. Non-linear autoregressive distributed lag models was implemented to explore if there is a short-term and/or long-term relationship of increases and decreases in influenza death rates with suicide rates during 1910-1978.\r\n\r\nBetween 1910 and 1978, there was no evidence of either short-term or long-term significant associations between influenza death rates and changes in suicides (\u03b2 coefficients of 0.00002, p=0.931 and \u03b2=0.00103, p=0.764 for short-term relationship of increases and decreases in influenza death rates, respectively, with suicide rates, and \u03b2=-0.0002, p=0.998 and \u03b2=0.00211, p=0.962 for long-term relationship of increases and decreases in influenza death rates, respectively, with suicide rates). The same pattern emerged in separate analyses for men and women.\r\n\r\nWe found no evidence of short-term or long-term association between influenza death rates and suicide death rates across three 20th century pandemics.", "doi": "10.1136/bmjopen-2021-049302", "pmid": "34233997", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-049302"}, {"db": "pmc", "key": "PMC8266430"}, {"db": "URL", "key": "https://bmjopen.bmj.com/content/bmjopen/suppl/2021/07/07/bmjopen-2021-049302.DC1/bmjopen-2021-049302supp001_data_supplement.pdf", "description": "Numbers of deaths by influenza and suicide and total population for 1910-1978"}], "notes": [], "created": "2021-08-06T08:30:29.374Z", "modified": "2021-11-18T08:47:06.477Z"}, {"entity": "publication", "iuid": "cd0c0576dfbd45aba076d15ccad48f58", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd0c0576dfbd45aba076d15ccad48f58.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd0c0576dfbd45aba076d15ccad48f58"}}, "title": "Demographic and clinical characteristics of severe Covid-19 infections: a cross-sectional study from Mashhad University of Medical Sciences, Iran.", "authors": [{"family": "Goshayeshi", "given": "Ladan", "initials": "L"}, {"family": "Akbari Rad", "given": "Mina", "initials": "M"}, {"family": "Bergquist", "given": "Robert", "initials": "R"}, {"family": "Allahyari", "given": "Abolghasem", "initials": "A"}, {"family": "Hashemzadeh", "given": "Kamila", "initials": "K"}, {"family": "MUMS Covid-19 Research Team", "given": "", "initials": ""}, {"family": "Hoseini", "given": "Benyamin", "initials": "B", "orcid": "0000-0002-0355-6181", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a56dc3b14f8430fa3f011ef206976f4.json"}}], "type": "journal article", "published": "2021-07-07", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "issn-l": null, "volume": "21", "issue": "1", "pages": "656"}, "abstract": "Coronavirus Disease 2019 (Covid-19) is expanding worldwide. The characteristics of this infection in patients varies from country to country. To move forward, clinical data on infected patients are needed. Here, we report a comparison between fatalities and recovery of patients with severe Covid-19, based on demographic and clinical characteristics.\r\n\r\nBetween 5 March and 12 May 2020 in Mashhad, Iran, 1278 of 4000 suspected Covid-19 patients were confirmed positive by real-time reverse-transcriptase-polymerase-chain-reaction assay of upper respiratory specimens. We compared the demographic, exposure history and clinical symptoms of 925 survivors and 353 fatal cases with confirmed disease.\r\n\r\nMean (SD) age for all confirmed patients was 56.9 (18.7) years, 67.1 (15.9) years in fatal cases and 53.0 (18.3) years in survivors. Multivariate logistic regression analysis showed that the outcome of patients was associated with age (odds ratio = 1.049, P = 0.0001, 95% CI = 1.040-1.057). Despite a high burden of Covid-19 infections in the 30-39 and 40-49 year age groups, most of these (89.6 and 87.2%, respectively) recovered. The median (IQR) duration of hospitalization was 9.0 (6.0-14.0) days. The most prevalent co-morbidities were cardiovascular disorders (21%) and diabetes (16.3%). Dyspnoea (72.7%), cough (68.1%) and fever (63.8%) were the most frequent clinical symptoms. Healthcare workers, of whom two (3%) died, comprised 5.2% of infected cases. Combination antiviral and antibiotic therapy was used in 43.0% of cases.\r\n\r\nThe characteristics of severe Covid-19 varied substantially between fatal cases and survivors, with diabetes and cardiovascular disorders the most prevalent co-morbidities. In contrast to other studies, there were a higher number of fatalities in younger patients in our setting.", "doi": "10.1186/s12879-021-06363-6", "pmid": "34233638", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12879-021-06363-6"}, {"db": "pmc", "key": "PMC8261035"}], "notes": [], "created": "2021-08-06T08:33:39.532Z", "modified": "2021-11-18T08:22:21.313Z"}, {"entity": "publication", "iuid": "5f14b7f1e44e4454be7287fb1a635e96", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f14b7f1e44e4454be7287fb1a635e96.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f14b7f1e44e4454be7287fb1a635e96"}}, "title": "An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism.", "authors": [{"family": "Razzaq", "given": "Misbah", "initials": "M"}, {"family": "Iglesias", "given": "Maria Jesus", "initials": "MJ"}, {"family": "Ibrahim-Kosta", "given": "Manal", "initials": "M"}, {"family": "Goumidi", "given": "Louisa", "initials": "L"}, {"family": "Soukarieh", "given": "Omar", "initials": "O"}, {"family": "Proust", "given": "Carole", "initials": "C"}, {"family": "Roux", "given": "Maguelonne", "initials": "M"}, {"family": "Suchon", "given": "Pierre", "initials": "P"}, {"family": "Boland", "given": "Anne", "initials": "A"}, {"family": "Daiain", "given": "Delphine", "initials": "D"}, {"family": "Olaso", "given": "Robert", "initials": "R"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Thalin", "given": "Charlotte", "initials": "C"}, {"family": "Butler", "given": "Lynn", "initials": "L"}, {"family": "Deleuze", "given": "Jean-Fran\u00e7ois", "initials": "J"}, {"family": "Odeberg", "given": "Jacob", "initials": "J"}, {"family": "Morange", "given": "Pierre-Emmanuel", "initials": "P"}, {"family": "Tr\u00e9gou\u00ebt", "given": "David-Alexandre", "initials": "D"}], "type": "journal article", "published": "2021-07-07", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "14015"}, "abstract": "Venous thromboembolism is the third common cardiovascular disease and is composed of two entities, deep vein thrombosis (DVT) and its potential fatal form, pulmonary embolism (PE). While PE is observed in ~ 40% of patients with documented DVT, there is limited biomarkers that can help identifying patients at high PE risk. To fill this need, we implemented a two hidden-layers artificial neural networks (ANN) on 376 antibodies and 19 biological traits measured in the plasma of 1388 DVT patients, with or without PE, of the MARTHA study. We used the LIME algorithm to obtain a linear approximate of the resulting ANN prediction model. As MARTHA patients were typed for genotyping DNA arrays, a genome wide association study (GWAS) was conducted on the LIME estimate. Detected single nucleotide polymorphisms (SNPs) were tested for association with PE risk in MARTHA. Main findings were replicated in the EOVT study composed of 143 PE patients and 196 DVT only patients. The derived ANN model for PE achieved an accuracy of 0.89 and 0.79 in our training and testing sets, respectively. A GWAS on the LIME approximate identified a strong statistical association peak (rs1424597: p = 5.3 \u00d7 10-7) at the PLXNA4 locus. Homozygote carriers for the rs1424597-A allele were then more frequently observed in PE than in DVT patients from the MARTHA (2% vs. 0.4%, p = 0.005) and the EOVT (3% vs. 0%, p = 0.013) studies. In a sample of 112 COVID-19 patients known to have endotheliopathy leading to acute lung injury and an increased risk of PE, decreased PLXNA4 levels were associated (p = 0.025) with worsened respiratory function. Using an original integrated proteomics and genetics strategy, we identified PLXNA4 as a new susceptibility gene for PE whose exact role now needs to be further elucidated.", "doi": "10.1038/s41598-021-93390-7", "pmid": "34234248", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-93390-7"}, {"db": "pmc", "key": "PMC8263618"}, {"db": "URL", "key": "https://zenodo.org/record/4280776#.YCEVVeoo-vc.", "description": "https://zenodo.org/record/4280776#.YCEVVeoo-vc."}], "notes": [], "created": "2021-08-06T08:25:57.051Z", "modified": "2022-02-14T17:54:22.941Z"}, {"entity": "publication", "iuid": "c6e34c3c36b54441ad20f3ed4f9ffd0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c6e34c3c36b54441ad20f3ed4f9ffd0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c6e34c3c36b54441ad20f3ed4f9ffd0e"}}, "title": "Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis.", "authors": [{"family": "Goubet", "given": "Anne-Ga\u00eblle", "initials": "AG", "orcid": "0000-0003-3431-3067", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/003b572826744aa4a622638867e8473b.json"}}, {"family": "Dubuisson", "given": "Agathe", "initials": "A", "orcid": "0000-0002-7526-0769", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb31612735e14dcda96cda1a050505af.json"}}, {"family": "Geraud", "given": "Arthur", "initials": "A"}, {"family": "Danlos", "given": "Fran\u00e7ois-Xavier", "initials": "FX"}, {"family": "Terrisse", "given": "Safae", "initials": "S"}, {"family": "Silva", "given": "Carolina Alves Costa", "initials": "CAC"}, {"family": "Drubay", "given": "Damien", "initials": "D"}, {"family": "Touri", "given": "Lea", "initials": "L"}, {"family": "Picard", "given": "Marion", "initials": "M"}, {"family": "Mazzenga", "given": "Marine", "initials": "M"}, {"family": "Silvin", "given": "Aymeric", "initials": "A"}, {"family": "Dunsmore", "given": "Garett", "initials": "G"}, {"family": "Haddad", "given": "Yacine", "initials": "Y"}, {"family": "Pizzato", "given": "Eugenie", "initials": "E"}, {"family": "Ly", "given": "Pierre", "initials": "P"}, {"family": "Flament", "given": "Caroline", "initials": "C"}, {"family": "Melenotte", "given": "Cl\u00e9a", "initials": "C"}, {"family": "Solary", "given": "Eric", "initials": "E", "orcid": "0000-0002-8629-1341", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5c0dc972ff945478e729c6ec852a31d.json"}}, {"family": "Fontenay", "given": "Michaela", "initials": "M"}, {"family": "Garcia", "given": "Gabriel", "initials": "G"}, {"family": "Balleyguier", "given": "Corinne", "initials": "C"}, {"family": "Lassau", "given": "Nathalie", "initials": "N"}, {"family": "Maeurer", "given": "Markus", "initials": "M"}, {"family": "Grajeda-Iglesias", "given": "Claudia", "initials": "C"}, {"family": "Nirmalathasan", "given": "Nitharsshini", "initials": "N"}, {"family": "Aprahamian", "given": "Fanny", "initials": "F"}, {"family": "Durand", "given": "Sylv\u00e8re", "initials": "S"}, {"family": "Kepp", "given": "Oliver", "initials": "O", "orcid": "0000-0002-6081-9558", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9c6472b9f7440289a5d69e4c3ce4242.json"}}, {"family": "Ferrere", "given": "Gladys", "initials": "G"}, {"family": "Thelemaque", "given": "Cassandra", "initials": "C"}, {"family": "Lahmar", "given": "Imran", "initials": "I"}, {"family": "Fahrner", "given": "Jean-Eudes", "initials": "JE", "orcid": "0000-0001-6581-8418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/377e7032a04e48889630c1b3b1752bc7.json"}}, {"family": "Meziani", "given": "Lydia", "initials": "L"}, {"family": "Ahmed-Belkacem", "given": "Abdelhakim", "initials": "A", "orcid": "0000-0001-6489-5091", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6210518b0774ba49795f0f323b95dcf.json"}}, {"family": "Sa\u00efdani", "given": "Nadia", "initials": "N"}, {"family": "La Scola", "given": "Bernard", "initials": "B"}, {"family": "Raoult", "given": "Didier", "initials": "D"}, {"family": "Gentile", "given": "St\u00e9phanie", "initials": "S"}, {"family": "Cortaredona", "given": "S\u00e9bastien", "initials": "S"}, {"family": "Ippolito", "given": "Giuseppe", "initials": "G", "orcid": "0000-0002-1076-2979", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e11491db391a466aa783fbebfb315b4e.json"}}, {"family": "Lelouvier", "given": "Benjamin", "initials": "B"}, {"family": "Roulet", "given": "Alain", "initials": "A"}, {"family": "Andre", "given": "Fabrice", "initials": "F"}, {"family": "Barlesi", "given": "Fabrice", "initials": "F"}, {"family": "Soria", "given": "Jean-Charles", "initials": "JC"}, {"family": "Pradon", "given": "Caroline", "initials": "C"}, {"family": "Gallois", "given": "Emmanuelle", "initials": "E"}, {"family": "Pommeret", "given": "Fanny", "initials": "F"}, {"family": "Colomba", "given": "Emeline", "initials": "E"}, {"family": "Ginhoux", "given": "Florent", "initials": "F", "orcid": "0000-0002-2857-7755", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/71216e36b29a430b9740ad40de938a22.json"}}, {"family": "Kazandjian", "given": "Suzanne", "initials": "S"}, {"family": "Elkrief", "given": "Arielle", "initials": "A"}, {"family": "Routy", "given": "Bertrand", "initials": "B"}, {"family": "Miyara", "given": "Makoto", "initials": "M"}, {"family": "Gorochov", "given": "Guy", "initials": "G"}, {"family": "Deutsch", "given": "Eric", "initials": "E", "orcid": "0000-0002-8223-3697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09cfd1799b094229bb96399296b44812.json"}}, {"family": "Albiges", "given": "Laurence", "initials": "L"}, {"family": "Stoclin", "given": "Annabelle", "initials": "A"}, {"family": "Gachot", "given": "Bertrand", "initials": "B"}, {"family": "Florin", "given": "Anne", "initials": "A"}, {"family": "Merad", "given": "Mansouria", "initials": "M"}, {"family": "Scotte", "given": "Florian", "initials": "F"}, {"family": "Assaad", "given": "Souad", "initials": "S"}, {"family": "Kroemer", "given": "Guido", "initials": "G", "orcid": "0000-0002-9334-4405", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d17de2122d0429eaa48a733bf2ad28e.json"}}, {"family": "Blay", "given": "Jean-Yves", "initials": "JY", "orcid": "0000-0001-7190-120X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0021df4cfc98475db66480f47f20f6ed.json"}}, {"family": "Marabelle", "given": "Aur\u00e9lien", "initials": "A", "orcid": "0000-0002-5816-3019", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dfe92c547ebd4c5a9915777c1b1580b5.json"}}, {"family": "Griscelli", "given": "Frank", "initials": "F"}, {"family": "Zitvogel", "given": "Laurence", "initials": "L", "orcid": "0000-0003-1596-0998", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b10947c1a2b4884b3f502625a28c5e0.json"}}, {"family": "Derosa", "given": "Lisa", "initials": "L"}], "type": "journal article", "published": "2021-07-06", "journal": {"title": "Cell Death Differ", "issn": "1476-5403", "issn-l": null}, "abstract": "Patients with cancer are at higher risk of severe coronavirus infectious disease 2019 (COVID-19), but the mechanisms underlying virus-host interactions during cancer therapies remain elusive. When comparing nasopharyngeal swabs from cancer and noncancer patients for RT-qPCR cycle thresholds measuring acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in 1063 patients (58% with cancer), we found that malignant disease favors the magnitude and duration of viral RNA shedding concomitant with prolonged serum elevations of type 1 IFN that anticorrelated with anti-RBD IgG antibodies. Cancer patients with a prolonged SARS-CoV-2 RNA detection exhibited the typical immunopathology of severe COVID-19 at the early phase of infection including circulation of immature neutrophils, depletion of nonconventional monocytes, and a general lymphopenia that, however, was accompanied by a rise in plasmablasts, activated follicular T-helper cells, and non-naive Granzyme B+FasL+, EomeshighTCF-1high, PD-1+CD8+ Tc1 cells. Virus-induced lymphopenia worsened cancer-associated lymphocyte loss, and low lymphocyte counts correlated with chronic SARS-CoV-2 RNA shedding, COVID-19 severity, and a higher risk of cancer-related death in the first and second surge of the pandemic. Lymphocyte loss correlated with significant changes in metabolites from the polyamine and biliary salt pathways as well as increased blood DNA from Enterobacteriaceae and Micrococcaceae gut family members in long-term viral carriers. We surmise that cancer therapies may exacerbate the paradoxical association between lymphopenia and COVID-19-related immunopathology, and that the prevention of COVID-19-induced lymphocyte loss may reduce cancer-associated death.", "doi": "10.1038/s41418-021-00817-9", "pmid": "34230615", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41418-021-00817-9"}, {"db": "pmc", "key": "PMC8259103"}], "notes": [], "created": "2021-08-06T08:35:17.454Z", "modified": "2021-08-06T08:35:17.732Z"}, {"entity": "publication", "iuid": "335924efcd6347e3b429b4cd0e13559e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/335924efcd6347e3b429b4cd0e13559e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/335924efcd6347e3b429b4cd0e13559e"}}, "title": "Mendelian randomization analysis provides causality of smoking on the expression of ACE2, a putative SARS-CoV-2 receptor.", "authors": [{"family": "Liu", "given": "Hui", "initials": "H", "orcid": "0000-0002-5531-3640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/834c6d4bd0fe438890f5b0cae725692e.json"}}, {"family": "Xin", "given": "Junyi", "initials": "J", "orcid": "0000-0001-6677-3936", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05e1800a0c744052a2302ae98907dc4b.json"}}, {"family": "Cai", "given": "Sheng", "initials": "S"}, {"family": "Jiang", "given": "Xia", "initials": "X", "orcid": "0000-0001-5878-8986", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d87c42578c2b4d34bdcd126c84bdef52.json"}}], "type": "journal article", "published": "2021-07-06", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "10", "issn-l": null}, "abstract": "To understand a causal role of modifiable lifestyle factors in angiotensin-converting enzyme 2 (ACE2) expression (a putative severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] receptor) across 44 human tissues/organs, and in coronavirus disease 2019 (COVID-19) susceptibility and severity, we conducted a phenome-wide two-sample Mendelian randomization (MR) study.\n\nMore than 500 genetic variants were used as instrumental variables to predict smoking and alcohol consumption. Inverse-variance weighted approach was adopted as the primary method to estimate a causal association, while MR-Egger regression, weighted median, and MR pleiotropy residual sum and outlier (MR-PRESSO) were performed to identify potential horizontal pleiotropy.\n\nWe found that genetically predicted smoking intensity significantly increased ACE2 expression in thyroid (\u03b2=1.468, p=1.8\u00d710-8), and increased ACE2 expression in adipose, brain, colon, and liver with nominal significance. Additionally, genetically predicted smoking initiation significantly increased the risk of COVID-19 onset (odds ratio=1.14, p=8.7\u00d710-5). No statistically significant result was observed for alcohol consumption.\n\nOur work demonstrates an important role of smoking, measured by both status and intensity, in the susceptibility to COVID-19.\n\nXJ is supported by research grants from the Swedish Research Council (VR-2018-02247) and Swedish Research Council for Health, Working Life and Welfare (FORTE-2020-00884).", "doi": "10.7554/eLife.64188", "pmid": "34227468", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "64188"}, {"db": "pmc", "key": "PMC8282334"}], "notes": [], "created": "2021-08-06T08:40:08.264Z", "modified": "2021-08-06T08:40:19.359Z"}, {"entity": "publication", "iuid": "4ee333715e0a46dd95a2041abd266fbd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ee333715e0a46dd95a2041abd266fbd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ee333715e0a46dd95a2041abd266fbd"}}, "title": "Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis.", "authors": [{"family": "WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group", "given": "", "initials": ""}, {"family": "Shankar-Hari", "given": "Manu", "initials": "M"}, {"family": "Vale", "given": "Claire L", "initials": "CL"}, {"family": "Godolphin", "given": "Peter J", "initials": "PJ"}, {"family": "Fisher", "given": "David", "initials": "D"}, {"family": "Higgins", "given": "Julian P T", "initials": "JPT"}, {"family": "Spiga", "given": "Francesca", "initials": "F"}, {"family": "Savovic", "given": "Jelena", "initials": "J"}, {"family": "Tierney", "given": "Jayne", "initials": "J"}, {"family": "Baron", "given": "Gabriel", "initials": "G"}, {"family": "Benbenishty", "given": "Julie S", "initials": "JS"}, {"family": "Berry", "given": "Lindsay R", "initials": "LR"}, {"family": "Broman", "given": "Niklas", "initials": "N"}, {"family": "Cavalcanti", "given": "Alexandre Biasi", "initials": "AB"}, {"family": "Colman", "given": "Roos", "initials": "R"}, {"family": "De Buyser", "given": "Stefanie L", "initials": "SL"}, {"family": "Derde", "given": "Lennie P G", "initials": "LPG"}, {"family": "Domingo", "given": "Pere", "initials": "P"}, {"family": "Omar", "given": "Sharifah Faridah", "initials": "SF"}, {"family": "Fernandez-Cruz", "given": "Ana", "initials": "A"}, {"family": "Feuth", "given": "Thijs", "initials": "T"}, {"family": "Garcia", "given": "Felipe", "initials": "F"}, {"family": "Garcia-Vicuna", "given": "Rosario", "initials": "R"}, {"family": "Gonzalez-Alvaro", "given": "Isidoro", "initials": "I"}, {"family": "Gordon", "given": "Anthony C", "initials": "AC"}, {"family": "Haynes", "given": "Richard", "initials": "R"}, {"family": "Hermine", "given": "Olivier", "initials": "O"}, {"family": "Horby", "given": "Peter W", "initials": "PW"}, {"family": "Horick", "given": "Nora K", "initials": "NK"}, {"family": "Kumar", "given": "Kuldeep", "initials": "K"}, {"family": "Lambrecht", "given": "Bart N", "initials": "BN"}, {"family": "Landray", "given": "Martin J", "initials": "MJ"}, {"family": "Leal", "given": "Lorna", "initials": "L"}, {"family": "Lederer", "given": "David J", "initials": "DJ"}, {"family": "Lorenzi", "given": "Elizabeth", "initials": "E"}, {"family": "Mariette", "given": "Xavier", "initials": "X"}, {"family": "Merchante", "given": "Nicolas", "initials": "N"}, {"family": "Misnan", "given": "Nor Arisah", "initials": "NA"}, {"family": "Mohan", "given": "Shalini V", "initials": "SV"}, {"family": "Nivens", "given": "Michael C", "initials": "MC"}, {"family": "Oksi", "given": "Jarmo", "initials": "J"}, {"family": "Perez-Molina", "given": "Jose A", "initials": "JA"}, {"family": "Pizov", "given": "Reuven", "initials": "R"}, {"family": "Porcher", "given": "Raphael", "initials": "R"}, {"family": "Postma", "given": "Simone", "initials": "S"}, {"family": "Rajasuriar", "given": "Reena", "initials": "R"}, {"family": "Ramanan", "given": "Athimalaipet V", "initials": "AV"}, {"family": "Ravaud", "given": "Philippe", "initials": "P"}, {"family": "Reid", "given": "Pankti D", "initials": "PD"}, {"family": "Rutgers", "given": "Abraham", "initials": "A"}, {"family": "Sancho-Lopez", "given": "Aranzazu", "initials": "A"}, {"family": "Seto", "given": "Todd B", "initials": "TB"}, {"family": "Sivapalasingam", "given": "Sumathi", "initials": "S"}, {"family": "Soin", "given": "Arvinder Singh", "initials": "AS"}, {"family": "Staplin", "given": "Natalie", "initials": "N"}, {"family": "Stone", "given": "John H", "initials": "JH"}, {"family": "Strohbehn", "given": "Garth W", "initials": "GW"}, {"family": "Sunden-Cullberg", "given": "Jonas", "initials": "J"}, {"family": "Torre-Cisneros", "given": "Julian", "initials": "J"}, {"family": "Tsai", "given": "Larry W", "initials": "LW"}, {"family": "van Hoogstraten", "given": "Hubert", "initials": "H"}, {"family": "van Meerten", "given": "Tom", "initials": "T"}, {"family": "Veiga", "given": "Viviane Cordeiro", "initials": "VC"}, {"family": "Westerweel", "given": "Peter E", "initials": "PE"}, {"family": "Murthy", "given": "Srinivas", "initials": "S"}, {"family": "Diaz", "given": "Janet V", "initials": "JV"}, {"family": "Marshall", "given": "John C", "initials": "JC"}, {"family": "Sterne", "given": "Jonathan A C", "initials": "JAC"}], "type": "journal article", "published": "2021-07-06", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484"}, "abstract": "Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized for COVID-19 have variously reported benefit, no effect, and harm.\n\nTo estimate the association between administration of IL-6 antagonists compared with usual care or placebo and 28-day all-cause mortality and other outcomes.\n\nTrials were identified through systematic searches of electronic databases between October 2020 and January 2021. Searches were not restricted by trial status or language. Additional trials were identified through contact with experts.\n\nEligible trials randomly assigned patients hospitalized for COVID-19 to a group in whom IL-6 antagonists were administered and to a group in whom neither IL-6 antagonists nor any other immunomodulators except corticosteroids were administered. Among 72 potentially eligible trials, 27 (37.5%) met study selection criteria.\n\nIn this prospective meta-analysis, risk of bias was assessed using the Cochrane Risk of Bias Assessment Tool. Inconsistency among trial results was assessed using the I2 statistic. The primary analysis was an inverse variance-weighted fixed-effects meta-analysis of odds ratios (ORs) for 28-day all-cause mortality.\n\nThe primary outcome measure was all-cause mortality at 28 days after randomization. There were 9 secondary outcomes including progression to invasive mechanical ventilation or death and risk of secondary infection by 28 days.\n\nA total of 10 930 patients (median age, 61 years [range of medians, 52-68 years]; 3560 [33%] were women) participating in 27 trials were included. By 28 days, there were 1407 deaths among 6449 patients randomized to IL-6 antagonists and 1158 deaths among 4481 patients randomized to usual care or placebo (summary OR, 0.86 [95% CI, 0.79-0.95]; P = .003 based on a fixed-effects meta-analysis). This corresponds to an absolute mortality risk of 22% for IL-6 antagonists compared with an assumed mortality risk of 25% for usual care or placebo. The corresponding summary ORs were 0.83 (95% CI, 0.74-0.92; P < .001) for tocilizumab and 1.08 (95% CI, 0.86-1.36; P = .52) for sarilumab. The summary ORs for the association with mortality compared with usual care or placebo in those receiving corticosteroids were 0.77 (95% CI, 0.68-0.87) for tocilizumab and 0.92 (95% CI, 0.61-1.38) for sarilumab. The ORs for the association with progression to invasive mechanical ventilation or death, compared with usual care or placebo, were 0.77 (95% CI, 0.70-0.85) for all IL-6 antagonists, 0.74 (95% CI, 0.66-0.82) for tocilizumab, and 1.00 (95% CI, 0.74-1.34) for sarilumab. Secondary infections by 28 days occurred in 21.9% of patients treated with IL-6 antagonists vs 17.6% of patients treated with usual care or placebo (OR accounting for trial sample sizes, 0.99; 95% CI, 0.85-1.16).\n\nIn this prospective meta-analysis of clinical trials of patients hospitalized for COVID-19, administration of IL-6 antagonists, compared with usual care or placebo, was associated with lower 28-day all-cause mortality.\n\nPROSPERO Identifier: CRD42021230155.", "doi": "10.1001/jama.2021.11330", "pmid": "34228774", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "2781880"}, {"db": "pmc", "key": "PMC8261689"}], "notes": [], "created": "2021-08-06T08:36:54.854Z", "modified": "2021-08-06T08:37:13.476Z"}, {"entity": "publication", "iuid": "a6dcc2a2bf4a4852b94c061b5e660397", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6dcc2a2bf4a4852b94c061b5e660397.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6dcc2a2bf4a4852b94c061b5e660397"}}, "title": "SARS-CoV-2-specific humoral and cellular immunity persists through 9 months irrespective of COVID-19 severity at hospitalisation.", "authors": [{"family": "Sandberg", "given": "John Tyler", "initials": "JT", "orcid": "0000-0001-6747-6933", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dfe4b6f5f2f24420bd78d7ae9b71e2d4.json"}}, {"family": "Varnait\u0117", "given": "Renata", "initials": "R", "orcid": "0000-0001-9391-9291", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05a03781d1c84aad85895298c193c575.json"}}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f2dc27d02294a15a6f691be6aab641f.json"}}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Muvva", "given": "Jagadeeswara R", "initials": "JR"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Garc\u00eda", "given": "Marina", "initials": "M", "orcid": "0000-0002-9130-3933", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5b109d7a54e4c05a48e0f21c4432be6.json"}}, {"family": "Dzidic", "given": "Majda", "initials": "M"}, {"family": "Folkesson", "given": "Elin", "initials": "E"}, {"family": "Skagerberg", "given": "Magdalena", "initials": "M"}, {"family": "Ahl\u00e9n", "given": "Gustaf", "initials": "G"}, {"family": "Frelin", "given": "Lars", "initials": "L"}, {"family": "S\u00e4llberg", "given": "Matti", "initials": "M"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Blom", "given": "Kim", "initials": "K", "orcid": "0000-0002-5286-3735", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/636cd4b9609b43d9b6ddbb10a7e2553a.json"}}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Karolinska COVID\u201019 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-07-05", "journal": {"title": "Clin Transl Immunol", "issn": "2050-0068", "issn-l": null, "volume": "10", "issue": "7", "pages": "e1306"}, "abstract": "Humoral and cellular immunity to SARS-CoV-2 following COVID-19 will likely contribute to protection from reinfection or severe disease. It is therefore important to characterise the initiation and persistence of adaptive immunity to SARS-CoV-2 amidst the ongoing pandemic.\n\nHere, we conducted a longitudinal study on hospitalised moderate and severe COVID-19 patients from the acute phase of disease into convalescence at 5 and 9 months post-symptom onset. Utilising flow cytometry, serological assays as well as B cell and T cell FluoroSpot assays, we assessed the magnitude and specificity of humoral and cellular immune responses during and after human SARS-CoV-2 infection.\n\nDuring acute COVID-19, we observed an increase in germinal centre activity, a substantial expansion of antibody-secreting cells and the generation of SARS-CoV-2-neutralising antibodies. Despite gradually decreasing antibody levels, we show persistent, neutralising antibody titres as well as robust specific memory B cell responses and polyfunctional T cell responses at 5 and 9 months after symptom onset in both moderate and severe COVID-19 patients.\n\nOur findings describe the initiation and, importantly, persistence of cellular and humoral SARS-CoV-2-specific immunological memory in hospitalised COVID-19 patients long after recovery, likely contributing towards protection against reinfection.", "doi": "10.1002/cti2.1306", "pmid": "34257967", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC8256672"}, {"db": "pii", "key": "CTI21306"}], "notes": [], "created": "2021-08-06T07:28:49.240Z", "modified": "2023-06-19T14:32:39.642Z"}, {"entity": "publication", "iuid": "a8a1f08519534f2b9ad1e1c26c3c0bd6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8a1f08519534f2b9ad1e1c26c3c0bd6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8a1f08519534f2b9ad1e1c26c3c0bd6"}}, "title": "Randomised, controlled, open label, multicentre clinical trial to explore safety and efficacy of hyperbaric oxygen for preventing ICU admission, morbidity and mortality in adult patients with COVID-19.", "authors": [{"family": "Kjellberg", "given": "Anders", "initials": "A", "orcid": "0000-0002-4819-1024", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81941232265d46679c08c40c068e91c4.json"}}, {"family": "Douglas", "given": "Johan", "initials": "J"}, {"family": "Pawlik", "given": "Michael T", "initials": "MT"}, {"family": "Kraus", "given": "Michael", "initials": "M"}, {"family": "Oscarsson", "given": "Nicklas", "initials": "N", "orcid": "0000-0002-0460-1829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1cbe3fa1d184960b75b8c4d9f3815a5.json"}}, {"family": "Zheng", "given": "Xiaowei", "initials": "X", "orcid": "0000-0002-2648-1119", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11b4ff5b9cea4b20afef48998931a75d.json"}}, {"family": "Bergman", "given": "Peter", "initials": "P", "orcid": "0000-0003-3306-3713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15b7290255814a7b9a1a97c3cdb2fc26.json"}}, {"family": "Fr\u00e5nberg", "given": "Oskar", "initials": "O", "orcid": "0000-0001-7051-3256", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7cdc60d7c4cb4bd7973fb282761e6191.json"}}, {"family": "Kowalski", "given": "Jan H", "initials": "JH"}, {"family": "Nyren", "given": "Sven Paul", "initials": "SP"}, {"family": "Silvanius", "given": "M\u00e5rten", "initials": "M", "orcid": "0000-0002-4629-6324", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45f5315fd0084d31a810787a8768cfc2.json"}}, {"family": "Skold", "given": "Magnus", "initials": "M"}, {"family": "Catrina", "given": "Sergiu-Bogdan", "initials": "SB", "orcid": "0000-0002-6914-3902", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/855bdd67b10940528effc10f51b92e17.json"}}, {"family": "Rodriguez-Wallberg", "given": "Kenny A", "initials": "KA", "orcid": "0000-0003-4378-6181", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d45aa8a66f64858b4f9be050046e8a2.json"}}, {"family": "Lindholm", "given": "Peter", "initials": "P", "orcid": "0000-0002-0840-9244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e98ca6dca1542a3acbd5a0516f0254d.json"}}], "type": "journal article", "published": "2021-07-05", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "7", "pages": "e046738", "issn-l": "2044-6055"}, "abstract": "COVID-19 may cause severe pneumonitis and trigger a massive inflammatory response that requires ventilatory support. The intensive care unit (ICU)-mortality has been reported to be as high as 62%. Dexamethasone is the only of all anti-inflammatory drugs that have been tested to date that has shown a positive effect on mortality. We aim to explore if treatment with hyperbaric oxygen (HBO) is safe and effective for patients with severe COVID-19. Our hypothesis is that HBO can prevent ICU admission, morbidity and mortality by attenuating the inflammatory response. The primary objective is to evaluate if HBO reduces the number of ICU admissions compared with best practice treatment for COVID-19, main secondary objectives are to evaluate if HBO reduces the load on ICU resources, morbidity and mortality and to evaluate if HBO mitigates the inflammatory reaction in COVID-19.\n\nA randomised, controlled, phase II, open label, multicentre trial. 200 subjects with severe COVID-19 and at least two risk factors for mortality will be included. Baseline clinical data and blood samples will be collected before randomisation and repeated daily for 7 days, at days 14 and 30. Subjects will be randomised with a computer-based system to HBO, maximum five times during the first 7 days plus best practice treatment or only best practice treatment. The primary endpoint, ICU admission, is defined by criteria for selection for ICU. We will evaluate if HBO mitigates the inflammatory reaction in COVID-19 using molecular analyses. All parameters are recorded in an electronic case report form. An independent Data Safety Monitoring Board will review the safety parameters.\n\nThe trial is approved by The National Institutional Review Board in Sweden (2020-01705) and the Swedish Medical Product Agency (5.1-2020-36673). Positive, negative and any inconclusive results will be published in peer-reviewed scientific journals with open access.\n\nNCT04327505. EudraCT number: 2020-001349-37.", "doi": "10.1136/bmjopen-2020-046738", "pmid": "34226219", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-046738"}, {"db": "pmc", "key": "PMC8260306"}, {"db": "ClinicalTrials.gov", "key": "NCT04327505"}, {"db": "EudraCT", "key": "2020-001349-37"}], "notes": [], "created": "2021-08-06T08:44:46.219Z", "modified": "2021-08-06T08:44:46.421Z"}, {"entity": "publication", "iuid": "bb3af7105efd4b57a5877b70928dfa57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb3af7105efd4b57a5877b70928dfa57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb3af7105efd4b57a5877b70928dfa57"}}, "title": "Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1.", "authors": [{"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Orlova", "given": "Elizaveta", "initials": "E"}, {"family": "Sozaeva", "given": "Leila", "initials": "L"}, {"family": "L\u00e9vy", "given": "Romain", "initials": "R"}, {"family": "James", "given": "Alyssa", "initials": "A"}, {"family": "Schmitt", "given": "Monica M", "initials": "MM"}, {"family": "Ochoa", "given": "Sebastian", "initials": "S"}, {"family": "Kareva", "given": "Maria", "initials": "M"}, {"family": "Rodina", "given": "Yulia", "initials": "Y"}, {"family": "Gervais", "given": "Adrian", "initials": "A"}, {"family": "Le Voyer", "given": "Tom", "initials": "T"}, {"family": "Rosain", "given": "J\u00e9r\u00e9mie", "initials": "J"}, {"family": "Philippot", "given": "Quentin", "initials": "Q"}, {"family": "Neehus", "given": "Anna-Lena", "initials": "AL"}, {"family": "Shaw", "given": "Elana", "initials": "E"}, {"family": "Migaud", "given": "M\u00e9lanie", "initials": "M"}, {"family": "Bizien", "given": "Lucy", "initials": "L"}, {"family": "Ekwall", "given": "Olov", "initials": "O"}, {"family": "Berg", "given": "Stefan", "initials": "S"}, {"family": "Beccuti", "given": "Guglielmo", "initials": "G"}, {"family": "Ghizzoni", "given": "Lucia", "initials": "L"}, {"family": "Thiriez", "given": "G\u00e9rard", "initials": "G"}, {"family": "Pavot", "given": "Arthur", "initials": "A"}, {"family": "Goujard", "given": "C\u00e9cile", "initials": "C"}, {"family": "Fr\u00e9mond", "given": "Marie-Louise", "initials": "ML"}, {"family": "Carter", "given": "Edwin", "initials": "E"}, {"family": "Rothenbuhler", "given": "Anya", "initials": "A"}, {"family": "Linglart", "given": "Agn\u00e8s", "initials": "A"}, {"family": "Mignot", "given": "Brigite", "initials": "B"}, {"family": "Comte", "given": "Aur\u00e9lie", "initials": "A"}, {"family": "Cheikh", "given": "Nathalie", "initials": "N"}, {"family": "Hermine", "given": "Olivier", "initials": "O"}, {"family": "Breivik", "given": "Lars", "initials": "L"}, {"family": "Husebye", "given": "Eystein S", "initials": "ES"}, {"family": "Humbert", "given": "S\u00e9bastien", "initials": "S"}, {"family": "Rohrlich", "given": "Pierre", "initials": "P"}, {"family": "Coaquette", "given": "Alain", "initials": "A"}, {"family": "Vuoto", "given": "Fanny", "initials": "F"}, {"family": "Faure", "given": "Karine", "initials": "K"}, {"family": "Mahlaoui", "given": "Nizar", "initials": "N"}, {"family": "Kotnik", "given": "Primo\u017e", "initials": "P"}, {"family": "Battelino", "given": "Tadej", "initials": "T"}, {"family": "Trebu\u0161ak Podkraj\u0161ek", "given": "Katarina", "initials": "K"}, {"family": "Kisand", "given": "Kai", "initials": "K"}, {"family": "Ferr\u00e9", "given": "Elise M N", "initials": "EMN"}, {"family": "DiMaggio", "given": "Thomas", "initials": "T"}, {"family": "Rosen", "given": "Lindsey B", "initials": "LB"}, {"family": "Burbelo", "given": "Peter D", "initials": "PD"}, {"family": "McIntyre", "given": "Martin", "initials": "M"}, {"family": "Kann", "given": "Nelli Y", "initials": "NY"}, {"family": "Shcherbina", "given": "Anna", "initials": "A"}, {"family": "Pavlova", "given": "Maria", "initials": "M"}, {"family": "Kolodkina", "given": "Anna", "initials": "A"}, {"family": "Holland", "given": "Steven M", "initials": "SM"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Crow", "given": "Yanick J", "initials": "YJ"}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD"}, {"family": "Su", "given": "Helen C", "initials": "HC"}, {"family": "Abel", "given": "Laurent", "initials": "L"}, {"family": "Anderson", "given": "Mark S", "initials": "MS"}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E"}, {"family": "Neven", "given": "B\u00e9n\u00e9dicte", "initials": "B"}, {"family": "Puel", "given": "Anne", "initials": "A"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL"}, {"family": "Lionakis", "given": "Michail S", "initials": "MS"}], "type": "journal article", "published": "2021-07-05", "journal": {"title": "J Exp Med", "issn": "1540-9538", "volume": "218", "issue": "7", "issn-l": null}, "abstract": "Patients with biallelic loss-of-function variants of AIRE suffer from autoimmune polyendocrine syndrome type-1 (APS-1) and produce a broad range of autoantibodies (auto-Abs), including circulating auto-Abs neutralizing most type I interferons (IFNs). These auto-Abs were recently reported to account for at least 10% of cases of life-threatening COVID-19 pneumonia in the general population. We report 22 APS-1 patients from 21 kindreds in seven countries, aged between 8 and 48 yr and infected with SARS-CoV-2 since February 2020. The 21 patients tested had auto-Abs neutralizing IFN-\u03b1 subtypes and/or IFN-\u03c9; one had anti-IFN-\u03b2 and another anti-IFN-\u03b5, but none had anti-IFN-\u03ba. Strikingly, 19 patients (86%) were hospitalized for COVID-19 pneumonia, including 15 (68%) admitted to an intensive care unit, 11 (50%) who required mechanical ventilation, and four (18%) who died. Ambulatory disease in three patients (14%) was possibly accounted for by prior or early specific interventions. Preexisting auto-Abs neutralizing type I IFNs in APS-1 patients confer a very high risk of life-threatening COVID-19 pneumonia at any age.", "doi": "10.1084/jem.20210554", "pmid": "33890986", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Proteins": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "212019"}], "notes": [], "created": "2021-04-29T15:37:10.750Z", "modified": "2021-04-29T15:37:10.760Z"}, {"entity": "publication", "iuid": "3dcd82f3a4c5470d8cca7f78ab45bf73", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3dcd82f3a4c5470d8cca7f78ab45bf73.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3dcd82f3a4c5470d8cca7f78ab45bf73"}}, "title": "Fitness, strength and severity of COVID-19: a prospective register study of 1 559 187 Swedish conscripts.", "authors": [{"family": "Af Geijerstam", "given": "Agnes", "initials": "A", "orcid": "0000-0002-0897-6548", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ab4ce35a27d446da006cd3aece117c2.json"}}, {"family": "Mehlig", "given": "Kirsten", "initials": "K"}, {"family": "B\u00f6rjesson", "given": "Mats", "initials": "M"}, {"family": "Robertson", "given": "Josefina", "initials": "J"}, {"family": "Nyberg", "given": "Jenny", "initials": "J", "orcid": "0000-0002-4336-3886", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b78a1fdee10c49c8b1adc25be46e4e81.json"}}, {"family": "Adiels", "given": "Martin", "initials": "M"}, {"family": "Rosengren", "given": "Annika", "initials": "A"}, {"family": "\u00c5berg", "given": "Maria", "initials": "M"}, {"family": "Lissner", "given": "Lauren", "initials": "L"}], "type": "journal article", "published": "2021-07-05", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "7", "pages": "e051316"}, "abstract": "To investigate the possible connection between cardiorespiratory fitness (CRF) and muscle strength in early adulthood and severity of COVID-19 later in life.\r\n\r\nProspective registry-based cohort study.\r\n\r\n1 559 187 Swedish men, undergoing military conscription between 1968 and 2005 at a mean age of 18.3 (SD 0.73) years.\r\n\r\nHospitalisation, intensive care or death due to COVID-19 from March to September 2020, in relation to CRF and muscle strength.\r\n\r\nHigh CRF in late adolescence and early adulthood had a protective association with severe COVID-19 later in life with OR (95% CI) 0.76 (0.67 to 0.85) for hospitalisation (n=2 006), 0.61 (0.48 to 0.78) for intensive care (n=445) and 0.56 (0.37 to 0.85) for mortality (n=149), compared with the lowest category of CRF. The association remains unchanged when controlled for body mass index (BMI), blood pressure, chronic diseases and parental education level at baseline, and incident cardiovascular disease before 2020. Moreover, lower muscle strength in late adolescence showed a linear association with a higher risk of all three outcomes when controlled for BMI and height.\r\n\r\nPhysical fitness at a young age is associated with severity of COVID-19 many years later. This underscores the necessity to increase the general physical fitness of the population to offer protection against future viral pandemics.", "doi": "10.1136/bmjopen-2021-051316", "pmid": "34226237", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-051316"}, {"db": "pmc", "key": "PMC8260308"}], "notes": [], "created": "2021-08-06T08:42:38.882Z", "modified": "2021-11-18T08:21:04.348Z"}, {"entity": "publication", "iuid": "db38442d89774784b668ca7f58909833", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db38442d89774784b668ca7f58909833.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db38442d89774784b668ca7f58909833"}}, "title": "Site-Specific Steric Control of SARS-CoV-2 Spike Glycosylation.", "authors": [{"family": "Allen", "given": "Joel D", "initials": "JD", "orcid": "0000-0003-2547-968X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81deac3f18124364945b49be654210ed.json"}}, {"family": "Chawla", "given": "Himanshi", "initials": "H", "orcid": "0000-0001-9828-6593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/882a202ebc104941984b1a642ed2dbe1.json"}}, {"family": "Samsudin", "given": "Firdaus", "initials": "F"}, {"family": "Zuzic", "given": "Lorena", "initials": "L", "orcid": "0000-0002-7834-612X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18d2dac8ab53482ebd2d5d5ba0b5d658.json"}}, {"family": "Shivgan", "given": "Aishwary Tukaram", "initials": "AT", "orcid": "0000-0002-2032-8738", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aaab454de9af4638b44f42b80121e2cc.json"}}, {"family": "Watanabe", "given": "Yasunori", "initials": "Y", "orcid": "0000-0002-7952-1268", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bcf2603906ff489dae169ea389b7a26a.json"}}, {"family": "He", "given": "Wan-Ting", "initials": "WT"}, {"family": "Callaghan", "given": "Sean", "initials": "S"}, {"family": "Song", "given": "Ge", "initials": "G"}, {"family": "Yong", "given": "Peter", "initials": "P", "orcid": "0000-0002-4899-3270", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ec57ed902be4604a6009335eeac6e92.json"}}, {"family": "Brouwer", "given": "Philip J M", "initials": "PJM"}, {"family": "Song", "given": "Yutong", "initials": "Y", "orcid": "0000-0002-2206-9549", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56c58af22e0d432cb6cfca65fc4feafb.json"}}, {"family": "Cai", "given": "Yongfei", "initials": "Y"}, {"family": "Duyvesteyn", "given": "Helen M E", "initials": "HME"}, {"family": "Malinauskas", "given": "Tomas", "initials": "T", "orcid": "0000-0002-4847-5529", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a331fc8e9eb434aadcc98f434a1e867.json"}}, {"family": "Kint", "given": "Joeri", "initials": "J"}, {"family": "Pino", "given": "Paco", "initials": "P"}, {"family": "Wurm", "given": "Maria J", "initials": "MJ"}, {"family": "Frank", "given": "Martin", "initials": "M", "orcid": "0000-0002-1006-6746", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee6b5d165615455da3cf49fad65598e9.json"}}, {"family": "Chen", "given": "Bing", "initials": "B"}, {"family": "Stuart", "given": "David I", "initials": "DI", "orcid": "0000-0002-3426-4210", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c24b849d3d54c2c9c7b0b68faed3d5a.json"}}, {"family": "Sanders", "given": "Rogier W", "initials": "RW"}, {"family": "Andrabi", "given": "Raiees", "initials": "R"}, {"family": "Burton", "given": "Dennis R", "initials": "DR"}, {"family": "Li", "given": "Sai", "initials": "S", "orcid": "0000-0002-9353-0355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56db840c41a54d52876c2ac1c8e5ec35.json"}}, {"family": "Bond", "given": "Peter J", "initials": "PJ", "orcid": "0000-0003-2900-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5bac218641b4642a498eafe60eafcf5.json"}}, {"family": "Crispin", "given": "Max", "initials": "M", "orcid": "0000-0002-1072-2694", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4341966010144757aa3af354e579c713.json"}}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "Biochemistry", "issn": "1520-4995", "issn-l": null}, "abstract": "A central tenet in the design of vaccines is the display of native-like antigens in the elicitation of protective immunity. The abundance of N-linked glycans across the SARS-CoV-2 spike protein is a potential source of heterogeneity among the many different vaccine candidates under investigation. Here, we investigate the glycosylation of recombinant SARS-CoV-2 spike proteins from five different laboratories and compare them against S protein from infectious virus, cultured in Vero cells. We find patterns that are conserved across all samples, and this can be associated with site-specific stalling of glycan maturation that acts as a highly sensitive reporter of protein structure. Molecular dynamics simulations of a fully glycosylated spike support a model of steric restrictions that shape enzymatic processing of the glycans. These results suggest that recombinant spike-based SARS-CoV-2 immunogen glycosylation reproducibly recapitulates signatures of viral glycosylation.", "doi": "10.1021/acs.biochem.1c00279", "pmid": "34213308", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-07-05T14:59:39.053Z", "modified": "2021-07-05T14:59:39.310Z"}, {"entity": "publication", "iuid": "4272a6d8972e4112944a7ff85e4a5385", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4272a6d8972e4112944a7ff85e4a5385.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4272a6d8972e4112944a7ff85e4a5385"}}, "title": "Perceived changes in capability during the COVID-19 pandemic: A Swedish cross-sectional study from June 2020.", "authors": [{"family": "Meili", "given": "Kaspar Walter", "initials": "KW"}, {"family": "Jonsson", "given": "H\u00e5kan", "initials": "H"}, {"family": "Lindholm", "given": "Lars", "initials": "L"}, {"family": "M\u00e5nsdotter", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": null, "issue": null, "pages": "14034948211023633"}, "abstract": "Measures against COVID-19 potentially impact quality of life in different ways. The capability approach by Amartya Sen with a broad and consistent framework for measuring quality of life is suited to capture the various consequences. We aimed to examine (a) whether individuals experienced change in 10 capability dimensions during the first half of 2020, (b) which dimensions were affected most, and (c) whether changes were unequally distributed in terms of gender, education, income, geography, housing, living situation and place of birth.\r\n\r\nWe assessed self-reported capability change in Sweden in 10 capability dimensions in a cross-sectional online survey among 500 participants on a five-item Likert scale. We analysed the distribution of answers by comparing the balance of positive and negative perceived changes and used mixed effects logistic regression to examine associations with background characteristics of the participants.\r\n\r\nReported perceived negative changes outweighed positive changes, and a higher proportion stated negative perceived changes if they also stated having low capability in the same dimension. In the capabilities of financial situation, political resources and health, the proportions of perceived negative change were highest. Odds for perceived negative change compared to no or positive change were higher for higher incomes, living in medium-sized municipalities, being born outside Europe, living in the south of Sweden, and renting instead of owning housing.\r\n\r\nSelf-reported negative capability change, and associated inequalities related to socioeconomic position, place of birth and regional residence should be of concern for policymakers.", "doi": "10.1177/14034948211023633", "pmid": "34213363", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "URL", "key": "https://snd.gu.se/sv/catalogue/study/2020-206/1/1#dataset", "description": "Dataset: capability change covid-19"}], "notes": [], "created": "2021-07-05T15:00:45.933Z", "modified": "2021-07-14T11:52:21.660Z"}, {"entity": "publication", "iuid": "d5f7250bfeb6416cb1876c988606d4d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5f7250bfeb6416cb1876c988606d4d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5f7250bfeb6416cb1876c988606d4d4"}}, "title": "Mobility restrictions were associated with reductions in COVID-19 incidence early in the pandemic: evidence from a real-time evaluation in 34 countries.", "authors": [{"family": "Oh", "given": "Juhwan", "initials": "J"}, {"family": "Lee", "given": "Hwa-Young", "initials": "HY"}, {"family": "Khuong", "given": "Quynh Long", "initials": "QL"}, {"family": "Markuns", "given": "Jeffrey F", "initials": "JF"}, {"family": "Bullen", "given": "Chris", "initials": "C"}, {"family": "Barrios", "given": "Osvaldo Enrique Artaza", "initials": "OEA"}, {"family": "Hwang", "given": "Seung-Sik", "initials": "SS"}, {"family": "Suh", "given": "Young Sahng", "initials": "YS"}, {"family": "McCool", "given": "Judith", "initials": "J"}, {"family": "Kachur", "given": "S Patrick", "initials": "SP"}, {"family": "Chan", "given": "Chang-Chuan", "initials": "CC"}, {"family": "Kwon", "given": "Soonman", "initials": "S"}, {"family": "Kondo", "given": "Naoki", "initials": "N"}, {"family": "Hoang", "given": "Van Minh", "initials": "VM"}, {"family": "Moon", "given": "J Robin", "initials": "JR"}, {"family": "Rostila", "given": "Mikael", "initials": "M"}, {"family": "Norheim", "given": "Ole F", "initials": "OF"}, {"family": "You", "given": "Myoungsoon", "initials": "M"}, {"family": "Withers", "given": "Mellissa", "initials": "M"}, {"family": "Li", "given": "Mu", "initials": "M"}, {"family": "Lee", "given": "Eun-Jeung", "initials": "EJ"}, {"family": "Benski", "given": "Caroline", "initials": "C"}, {"family": "Park", "given": "Sookyung", "initials": "S"}, {"family": "Nam", "given": "Eun-Woo", "initials": "EW"}, {"family": "Gottschalk", "given": "Katie", "initials": "K"}, {"family": "Kavanagh", "given": "Matthew M", "initials": "MM"}, {"family": "Tran", "given": "Thi Giang Huong", "initials": "TGH"}, {"family": "Lee", "given": "Jong-Koo", "initials": "JK"}, {"family": "Subramanian", "given": "S V", "initials": "SV"}, {"family": "McKee", "given": "Martin", "initials": "M"}, {"family": "Gostin", "given": "Lawrence O", "initials": "LO"}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "13717", "issn-l": "2045-2322"}, "abstract": "Most countries have implemented restrictions on mobility to prevent the spread of Coronavirus disease-19 (COVID-19), entailing considerable societal costs but, at least initially, based on limited evidence of effectiveness. We asked whether mobility restrictions were associated with changes in the occurrence of COVID-19 in 34 OECD countries plus Singapore and Taiwan. Our data sources were the Google Global Mobility Data Source, which reports different types of mobility, and COVID-19 cases retrieved from the dataset curated by Our World in Data. Beginning at each country's 100th case, and incorporating a 14-day lag to account for the delay between exposure and illness, we examined the association between changes in mobility (with January 3 to February 6, 2020 as baseline) and the ratio of the number of newly confirmed cases on a given day to the total number of cases over the past 14 days from the index day (the potentially infective 'pool' in that population), per million population, using LOESS regression and logit regression. In two-thirds of examined countries, reductions of up to 40% in commuting mobility (to workplaces, transit stations, retailers, and recreation) were associated with decreased cases, especially early in the pandemic. Once both mobility and incidence had been brought down, further restrictions provided little additional benefit. These findings point to the importance of acting early and decisively in a pandemic.", "doi": "10.1038/s41598-021-92766-z", "pmid": "34215764", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-92766-z"}], "notes": [], "created": "2021-07-05T15:01:41.748Z", "modified": "2021-07-05T15:01:41.761Z"}, {"entity": "publication", "iuid": "5b593319005f4e1aa7583b3cadcdced8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5b593319005f4e1aa7583b3cadcdced8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5b593319005f4e1aa7583b3cadcdced8"}}, "title": "Increased rate of hospitalisation for COVID-19 among rituximab-treated multiple sclerosis patients: A study of the Swedish multiple sclerosis registry.", "authors": [{"family": "Spelman", "given": "Tim", "initials": "T", "orcid": "0000-0001-9204-3216", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab24deed7243491387cb220c2a0c8606.json"}}, {"family": "Forsberg", "given": "Lars", "initials": "L"}, {"family": "McKay", "given": "Kyla", "initials": "K"}, {"family": "Glaser", "given": "Anna", "initials": "A"}, {"family": "Hillert", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "Mult Scler", "issn": "1477-0970", "pages": "13524585211026272", "issn-l": null}, "abstract": "The primary objective of this study was to analyse the association between multiple sclerosis (MS) disease-modifying therapy (DMT) exposure and hospitalisation in patients infected with COVID-19.\n\nAssociations between MS DMT exposure and COVID-19 hospitalisation were analysed using univariable and multi-variable-clustered propensity score weighted logistic regression, where the models were clustered on the individual patients to control for patients contributing multiple COVID-19 episodes.\n\nAs of 18 January 2021, a total of 476 reported COVID-19 cases had been recorded in MS patients in the Swedish MS registry. Of these, 292 (61.3%) had confirmed COVID-19. The mean value (standard deviation (SD)) age at infection was 44.0 years (11.6). Of the 292 confirmed infections, 68 (23.2%) required hospitalisation. A total of 49 of the 164 confirmed COVID-19 patients on rituximab at baseline (29.9%) required hospitalisation, compared to a rate of 12.7% for all other DMTs combined. Rituximab in confirmed COVID-19 patients was associated with 2.95 times the odds of hospitalisation relative to any other DMT combined (odds ratio = 2.95; 95% confidence interval (CI) = 1.48-5.87).\n\nRituximab treatment, known to increase the risk of severe infections in general, also confers such a risk for MS patients with COVID-19, in comparison with other MS DMTs.", "doi": "10.1177/13524585211026272", "pmid": "34212816", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-07-05T14:58:20.082Z", "modified": "2021-07-05T14:58:20.119Z"}, {"entity": "publication", "iuid": "be233521a08a4dd8a582810f62e9423d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be233521a08a4dd8a582810f62e9423d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be233521a08a4dd8a582810f62e9423d"}}, "title": "High Amounts of SARS-CoV-2 Precede Sickness Among Asymptomatic Health Care Workers.", "authors": [{"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Elfstr\u00f6m", "given": "K Miriam", "initials": "KM"}, {"family": "Blomqvist", "given": "Jonas", "initials": "J"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M"}, {"family": "Eklund", "given": "Carina", "initials": "C"}, {"family": "Boulund", "given": "Fredrik", "initials": "F"}, {"family": "Lagheden", "given": "Camilla", "initials": "C"}, {"family": "Hamsten", "given": "Marica", "initials": "M"}, {"family": "Nordqvist-Kleppe", "given": "Sara", "initials": "S"}, {"family": "Seifert", "given": "Maike", "initials": "M"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Olofsson", "given": "Jennie", "initials": "J"}, {"family": "Andersson", "given": "Eni", "initials": "E"}, {"family": "Falk", "given": "August Jernbom", "initials": "AJ"}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S"}, {"family": "Hultin", "given": "Emilie", "initials": "E"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Pimenoff", "given": "Ville N", "initials": "VN"}, {"family": "Hassan", "given": "Sadaf", "initials": "S"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Mattsson", "given": "Johan", "initials": "J"}, {"family": "Arroyo M\u00fchr", "given": "Laila Sara", "initials": "LS"}, {"family": "Lundgren", "given": "Kalle Conneryd", "initials": "KC"}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899", "volume": "224", "issue": "1", "pages": "14-20"}, "abstract": "Whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positivity among asymptomatic subjects reflects past or future disease may be difficult to ascertain.\n\nWe tested 9449 employees at Karolinska University Hospital, Stockholm, Sweden for SARS-CoV-2 RNA and antibodies, linked the results to sick leave records, and determined associations with past or future sick leave using multinomial logistic regression.\n\nSubjects with high amounts of SARS-CoV-2 virus, indicated by polymerase chain reaction (PCR) cycle threshold (Ct) value, had the highest risk for sick leave in the 2 weeks after testing (odds ratio [OR], 11.97; 95% confidence interval [CI], 6.29-22.80) whereas subjects with low amounts of virus had the highest risk for sick leave in the 3 weeks before testing (OR, 6.31; 95% CI, 4.38-9.08). Only 2.5% of employees were SARS-CoV-2 positive while 10.5% were positive by serology and 1.2% were positive in both tests. Serology-positive subjects were not at excess risk for future sick leave (OR, 1.06; 95% CI, .71-1.57).\n\nHigh amounts of SARS-CoV-2 virus, as determined using PCR Ct values, was associated with development of sickness in the next few weeks. Results support the concept that PCR Ct may be informative when testing for SARS-CoV-2. Clinical Trials Registration. NCT04411576.", "doi": "10.1093/infdis/jiab099", "pmid": "33580261", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Research Area: High-throughput and high-content serology": null}, "xrefs": [{"db": "pmc", "key": "PMC7928785"}, {"db": "pii", "key": "6134453"}, {"db": "ClinicalTrials.gov", "key": "NCT04411576"}], "notes": [], "created": "2021-02-15T12:44:13.720Z", "modified": "2023-06-19T14:23:42.228Z"}, {"entity": "publication", "iuid": "b819f37c7eef4cc6b647ccab35dd3af4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b819f37c7eef4cc6b647ccab35dd3af4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b819f37c7eef4cc6b647ccab35dd3af4"}}, "title": "Frequency of Thrombocytopenia and Platelet Factor 4/Heparin Antibodies in Patients With Cerebral Venous Sinus Thrombosis Prior to the COVID-19 Pandemic.", "authors": [{"family": "S\u00e1nchez van Kammen", "given": "Mayte", "initials": "M"}, {"family": "Heldner", "given": "Mirjam R", "initials": "MR"}, {"family": "Brodard", "given": "Justine", "initials": "J"}, {"family": "Scutelnic", "given": "Adrian", "initials": "A"}, {"family": "Silvis", "given": "Suzanne", "initials": "S"}, {"family": "Schroeder", "given": "Verena", "initials": "V"}, {"family": "Kremer Hovinga", "given": "Johanna A", "initials": "JA"}, {"family": "Middeldorp", "given": "Saskia", "initials": "S"}, {"family": "Levi", "given": "Marcel", "initials": "M"}, {"family": "Hiltunen", "given": "Sini", "initials": "S"}, {"family": "Lindgren", "given": "Erik", "initials": "E"}, {"family": "Mansour", "given": "Maryam", "initials": "M"}, {"family": "Arauz", "given": "Antonio", "initials": "A"}, {"family": "Barboza", "given": "Miguel A", "initials": "MA"}, {"family": "Zuurbier", "given": "Susanna M", "initials": "SM"}, {"family": "Aguiar de Sousa", "given": "Diana", "initials": "D"}, {"family": "Ferro", "given": "Jose M", "initials": "JM"}, {"family": "Fischer", "given": "Urs", "initials": "U"}, {"family": "Field", "given": "Thalia S", "initials": "TS"}, {"family": "Jood", "given": "Katarina", "initials": "K"}, {"family": "Tatlisumak", "given": "Turgut", "initials": "T"}, {"family": "Putaala", "given": "Jukka", "initials": "J"}, {"family": "Arnold", "given": "Marcel", "initials": "M"}, {"family": "Coutinho", "given": "Jonathan M", "initials": "JM"}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484"}, "abstract": "Cases of cerebral venous sinus thrombosis in combination with thrombocytopenia have recently been reported within 4 to 28 days of vaccination with the ChAdOx1 nCov-19 (AstraZeneca/Oxford) and Ad.26.COV2.S (Janssen/Johnson & Johnson) COVID-19 vaccines. An immune-mediated response associated with platelet factor 4/heparin antibodies has been proposed as the underlying pathomechanism.\n\nTo determine the frequencies of admission thrombocytopenia, heparin-induced thrombocytopenia, and presence of platelet factor 4/heparin antibodies in patients diagnosed with cerebral venous sinus thrombosis prior to the COVID-19 pandemic.\n\nThis was a descriptive analysis of a retrospective sample of consecutive patients diagnosed with cerebral venous sinus thrombosis between January 1987 and March 2018 from 7 hospitals participating in the International Cerebral Venous Sinus Thrombosis Consortium from Finland, the Netherlands, Switzerland, Sweden, Mexico, Iran, and Costa Rica. Of 952 patients, 865 with available baseline platelet count were included. In a subset of 93 patients, frozen plasma samples collected during a previous study between September 2009 and February 2016 were analyzed for the presence of platelet factor 4/heparin antibodies.\n\nDiagnosis of cerebral venous sinus thrombosis.\n\nFrequencies of admission thrombocytopenia (platelet count <150 \u00d7103/\u03bcL), heparin-induced thrombocytopenia (as diagnosed by the treating physician), and platelet factor 4/heparin IgG antibodies (optical density >0.4, in a subset of patients with previously collected plasma samples).\n\nOf 865 patients (median age, 40 years [interquartile range, 29-53 years], 70% women), 73 (8.4%; 95% CI, 6.8%-10.5%) had thrombocytopenia, which was mild (100-149 \u00d7103/\u03bcL) in 52 (6.0%), moderate (50-99 \u00d7103/\u03bcL) in 17 (2.0%), and severe (<50 \u00d7103/\u03bcL) in 4 (0.5%). Heparin-induced thrombocytopenia with platelet factor 4/heparin antibodies was diagnosed in a single patient (0.1%; 95% CI, <0.1%-0.7%). Of the convenience sample of 93 patients with cerebral venous sinus thrombosis included in the laboratory analysis, 8 (9%) had thrombocytopenia, and none (95% CI, 0%-4%) had platelet factor 4/heparin antibodies.\n\nIn patients with cerebral venous sinus thrombosis prior to the COVID-19 pandemic, baseline thrombocytopenia was uncommon, and heparin-induced thrombocytopenia and platelet factor 4/heparin antibodies were rare. These findings may inform investigations of the possible association between the ChAdOx1 nCoV-19 and Ad26.COV2.S COVID-19 vaccines and cerebral venous sinus thrombosis with thrombocytopenia.", "doi": "10.1001/jama.2021.9889", "pmid": "34213527", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "2781791"}], "notes": [], "created": "2021-07-05T15:01:14.308Z", "modified": "2021-07-05T15:01:14.319Z"}, {"entity": "publication", "iuid": "510aa8ca7cef4ebdbb950f0fb539bc28", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/510aa8ca7cef4ebdbb950f0fb539bc28.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/510aa8ca7cef4ebdbb950f0fb539bc28"}}, "title": "Factors preventing SARS-CoV-2 transmission during unintentional exposure in a GP practice: a cohort study of patient contacts; Germany, 2020.", "authors": [{"family": "Boender", "given": "T Sonia", "initials": "TS", "orcid": "0000-0002-4418-3713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0d75319e2f6428c8319ffeca3f52128.json"}}, {"family": "Bender", "given": "Jennifer K", "initials": "JK", "orcid": "0000-0001-5167-3836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87d9bb9464334375911956504495bf54.json"}}, {"family": "Kr\u00fcger", "given": "Angelika", "initials": "A"}, {"family": "Michaelis", "given": "Kai", "initials": "K"}, {"family": "Buchholz", "given": "Udo", "initials": "U", "orcid": "0000-0001-6597-3995", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b447ca62aad648d5bc0fcd5246bf0ba7.json"}}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "pages": "1-17", "issn-l": null}, "abstract": null, "doi": "10.1017/S0950268821001503", "pmid": "34210375", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0950268821001503"}], "notes": [], "created": "2021-07-05T14:58:02.461Z", "modified": "2021-07-05T14:58:02.553Z"}, {"entity": "publication", "iuid": "0b39ec84783a4dff9c46a86c6c3e6882", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b39ec84783a4dff9c46a86c6c3e6882.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b39ec84783a4dff9c46a86c6c3e6882"}}, "title": "COVID-19 and the Digitalisation of Cardiovascular Training and Education-A Review of Guiding Themes for Equitable and Effective Post-graduate Telelearning.", "authors": [{"family": "Chong", "given": "Jun Hua", "initials": "JH"}, {"family": "Chahal", "given": "C Anwar A", "initials": "CAA"}, {"family": "Gupta", "given": "Ajay", "initials": "A"}, {"family": "Ricci", "given": "Fabrizio", "initials": "F"}, {"family": "Westwood", "given": "Mark", "initials": "M"}, {"family": "Pugliese", "given": "Francesca", "initials": "F"}, {"family": "Petersen", "given": "Steffen E", "initials": "SE"}, {"family": "Khanji", "given": "Mohammed Y", "initials": "MY"}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "Front Cardiovasc Med", "issn": "2297-055X", "volume": "8", "pages": "666119", "issn-l": null}, "abstract": "The coronavirus disease-2019 (COVID-19) pandemic has had an unprecedented impact leading to novel adaptations in post-graduate medical education for cardiovascular and general internal medicine. Whilst the results of initial community COVID-19 vaccination are awaited, continuation of multimodality teaching and training that incorporates telelearning will have enduring benefit to post-graduate education and will place educational establishments in good stead to nimbly respond in future pandemic-related public health emergencies. With the rise in innovative virtual learning solutions, medical educators will have to leverage technology to develop electronic educational materials and virtual courses that facilitate adult learning. Technology-enabled virtual learning is thus a timely progression of hybrid classroom initiatives that are already adopted to varying degrees, with a need for faculty to serve as subject matter experts, to host and moderate online discussions, and to provide feedback and overall mentorship. As an extension from existing efforts, simulation-based teaching (SBT) and learning and the use of mixed reality technology should also form a greater core in the cardiovascular medicine curriculum. We highlight five foundational themes for building a successful e-learning model in cardiovascular and general post-graduate medical training: (1) digital solutions and associated infrastructure; (2) equity in access; (3) participant engagement; (4) diversity and inclusion; and (5) patient confidentiality and governance framework. With digitalisation impacting our everyday lives and now how we teach and train in medicine, these five guiding principles provide a cognitive scaffold for careful consideration of the required ecosystem in which cardiovascular and general post-graduate medical education can effectively operate. With due consideration of various e-learning options and associated infrastructure needs; and adoption of strategies for participant engagement under sound and just governance, virtual training in medicine can be effective, inclusive and equitable through the COVID-19 era and beyond.", "doi": "10.3389/fcvm.2021.666119", "pmid": "34277728", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8283504"}], "notes": [], "created": "2021-08-05T11:13:06.304Z", "modified": "2021-08-05T11:13:06.327Z"}, {"entity": "publication", "iuid": "43b7e6f8efe34106853a4b413cf18a47", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/43b7e6f8efe34106853a4b413cf18a47.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/43b7e6f8efe34106853a4b413cf18a47"}}, "title": "Symptoms, symptom relief and support in COVID-19 patients dying in hospitals during the first pandemic wave.", "authors": [{"family": "Martinsson", "given": "Lisa", "initials": "L", "orcid": "0000-0003-4126-2675", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4341a69741544f5a98afc9620b7a698.json"}}, {"family": "Bergstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Hedman", "given": "Christel", "initials": "C"}, {"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "Lundstr\u00f6m", "given": "Staffan", "initials": "S"}], "type": "journal article", "published": "2021-07-01", "journal": {"title": "BMC Palliat Care", "issn": "1472-684X", "volume": "20", "issue": "1", "pages": "102", "issn-l": null}, "abstract": "At the time of the first wave of the COVID-19 pandemic in Sweden, little was known about how effective our regular end-of-life care strategies would be for patients dying from COVID-19 in hospitals. The aim of the study was to describe and evaluate end-of-life care for patients dying from COVID-19 in hospitals in Sweden up until up until 12 November 2020.\n\nData were collected from the Swedish Register of Palliative Care. Hospital deaths during 2020 for patients with COVID-19 were included and compared to a reference cohort of hospital patients who died during 2019. Logistic regression was used to compare the groups and to control for impact of sex, age and a diagnosis of dementia.\n\nThe COVID-19 group (1476 individuals) had a lower proportion of women and was older compared to the reference cohort (13,158 individuals), 81.8 versus 80.6 years (p < .001). Breathlessness was more commonly reported in the COVID-19 group compared to the reference cohort (72% vs 43%, p < .001). Furthermore, anxiety and delirium were more commonly and respiratory secretions, nausea and pain were less commonly reported during the last week in life in the COVID-19 group (p < .001 for all five symptoms). When present, complete relief of anxiety (p = .021), pain (p = .025) and respiratory secretions (p = .037) was more often achieved in the COVID-19 group. In the COVID-19 group, 57% had someone present at the time of death compared to 77% in the reference cohort (p < .001).\n\nThe standard medical strategies for symptom relief and end-of-life care in hospitals seemed to be acceptable. Symptoms in COVID-19 deaths in hospitals were relieved as much as or even to a higher degree than in hospitals in 2019. Importantly, though, as a result of closing the hospitals to relatives and visitors, patients dying from COVID-19 more frequently died alone, and healthcare providers were not able to substitute for absent relatives.", "doi": "10.1186/s12904-021-00785-4", "pmid": "34210312", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12904-021-00785-4"}], "notes": [], "created": "2021-07-05T14:57:39.411Z", "modified": "2021-07-05T14:57:39.464Z"}, {"entity": "publication", "iuid": "fbe1e98a162b4123b1d6a874566cf6d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fbe1e98a162b4123b1d6a874566cf6d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fbe1e98a162b4123b1d6a874566cf6d0"}}, "title": "Guidance for Health Care Leaders During the Recovery Stage of the COVID-19 Pandemic: A Consensus Statement.", "authors": [{"family": "Geerts", "given": "Jaason M", "initials": "JM"}, {"family": "Kinnair", "given": "Donna", "initials": "D"}, {"family": "Taheri", "given": "Paul", "initials": "P"}, {"family": "Abraham", "given": "Ajit", "initials": "A"}, {"family": "Ahn", "given": "Joonmo", "initials": "J"}, {"family": "Atun", "given": "Rifat", "initials": "R"}, {"family": "Barberia", "given": "Lorena", "initials": "L"}, {"family": "Best", "given": "Nigel J", "initials": "NJ"}, {"family": "Dandona", "given": "Rakhi", "initials": "R"}, {"family": "Dhahri", "given": "Adeel Abbas", "initials": "AA"}, {"family": "Emilsson", "given": "Louise", "initials": "L"}, {"family": "Free", "given": "Julian R", "initials": "JR"}, {"family": "Gardam", "given": "Michael", "initials": "M"}, {"family": "Geerts", "given": "William H", "initials": "WH"}, {"family": "Ihekweazu", "given": "Chikwe", "initials": "C"}, {"family": "Johnson", "given": "Shanthi", "initials": "S"}, {"family": "Kooijman", "given": "Allison", "initials": "A"}, {"family": "Lafontaine", "given": "Alika T", "initials": "AT"}, {"family": "Leshem", "given": "Eyal", "initials": "E"}, {"family": "Lidstone-Jones", "given": "Caroline", "initials": "C"}, {"family": "Loh", "given": "Erwin", "initials": "E"}, {"family": "Lyons", "given": "Oscar", "initials": "O"}, {"family": "Neel", "given": "Khalid Ali Fouda", "initials": "KAF"}, {"family": "Nyasulu", "given": "Peter S", "initials": "PS"}, {"family": "Razum", "given": "Oliver", "initials": "O"}, {"family": "Sabourin", "given": "H\u00e9l\u00e8ne", "initials": "H"}, {"family": "Schleifer Taylor", "given": "Jackie", "initials": "J"}, {"family": "Sharifi", "given": "Hamid", "initials": "H"}, {"family": "Stergiopoulos", "given": "Vicky", "initials": "V"}, {"family": "Sutton", "given": "Brett", "initials": "B"}, {"family": "Wu", "given": "Zunyou", "initials": "Z"}, {"family": "Bilodeau", "given": "Marc", "initials": "M"}], "type": "journal article", "published": "2021-07-01", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "volume": "4", "issue": "7", "pages": "e2120295", "issn-l": null}, "abstract": "The COVID-19 pandemic is the greatest global test of health leadership of our generation. There is an urgent need to provide guidance for leaders at all levels during the unprecedented preresolution recovery stage.\n\nTo create an evidence- and expertise-informed framework of leadership imperatives to serve as a resource to guide health and public health leaders during the postemergency stage of the pandemic.\n\nA literature search in PubMed, MEDLINE, and Embase revealed 10 910 articles published between 2000 and 2021 that included the terms leadership and variations of emergency, crisis, disaster, pandemic, COVID-19, or public health. Using the Standards for Quality Improvement Reporting Excellence reporting guideline for consensus statement development, this assessment adopted a 6-round modified Delphi approach involving 32 expert coauthors from 17 countries who participated in creating and validating a framework outlining essential leadership imperatives.\n\nThe 10 imperatives in the framework are: (1) acknowledge staff and celebrate successes; (2) provide support for staff well-being; (3) develop a clear understanding of the current local and global context, along with informed projections; (4) prepare for future emergencies (personnel, resources, protocols, contingency plans, coalitions, and training); (5) reassess priorities explicitly and regularly and provide purpose, meaning, and direction; (6) maximize team, organizational, and system performance and discuss enhancements; (7) manage the backlog of paused services and consider improvements while avoiding burnout and moral distress; (8) sustain learning, innovations, and collaborations, and imagine future possibilities; (9) provide regular communication and engender trust; and (10) in consultation with public health and fellow leaders, provide safety information and recommendations to government, other organizations, staff, and the community to improve equitable and integrated care and emergency preparedness systemwide.\n\nLeaders who most effectively implement these imperatives are ideally positioned to address urgent needs and inequalities in health systems and to cocreate with their organizations a future that best serves stakeholders and communities.", "doi": "10.1001/jamanetworkopen.2021.20295", "pmid": "34236416", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "2781729"}], "notes": [], "created": "2021-08-06T08:00:11.009Z", "modified": "2021-08-06T08:00:11.022Z"}, {"entity": "publication", "iuid": "e636443b37594ed2b682f780ac8e4390", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e636443b37594ed2b682f780ac8e4390.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e636443b37594ed2b682f780ac8e4390"}}, "title": "Fearing fear itself: Crowdsourced longitudinal data on Covid-19-related fear in Sweden.", "authors": [{"family": "Tishelman", "given": "Carol", "initials": "C", "orcid": "0000-0003-4161-0342", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1fbfdb57e5124e72bcffcce93b21fa05.json"}}, {"family": "Hultin-Rosenberg", "given": "Jonas", "initials": "J"}, {"family": "Hadders", "given": "Anna", "initials": "A"}, {"family": "Eriksson", "given": "Lars E", "initials": "LE", "orcid": "0000-0001-5121-5325", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09bec95869bc450aa97e0aa11485807e.json"}}], "type": "journal article", "published": "2021-07-01", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "7", "pages": "e0253371"}, "abstract": "The Covid-19 pandemic has had unprecedented effects on individual lives and livelihoods as well as on social, health, economic and political systems and structures across the world. This article derives from a unique collaboration between researchers and museums using rapid response crowdsourcing to document contemporary life among the general public during the pandemic crisis in Sweden.\r\n\r\nWe use qualitative analysis to explore the narrative crowdsourced submissions of the same 88 individuals at two timepoints, during the 1st and 2nd pandemic waves, about what they most fear in relation to the Covid-19 pandemic, and how their descriptions changed over time. In this self-selected group, we found that aspects they most feared generally concerned responses to the pandemic on a societal level, rather than to the Covid-19 disease itself or other health-related issues. The most salient fears included a broad array of societal issues, including general societal collapse and fears about effects on social and political interactions among people with resulting impact on political order. Notably strong support for the Swedish pandemic response was expressed, despite both national and international criticism.\r\n\r\nThis analysis fills a notable gap in research literature that lacks subjective and detailed investigation of experiences of the general public, despite recognition of the widespread effects of Covid-19 and its' management strategies. Findings address controversy about the role of experts in formulating and communicating strategy, as well as implications of human responses to existential threats. Based on this analysis, we call for broader focus on societal issues related to this existential threat and the responses to it.", "doi": "10.1371/journal.pone.0253371", "pmid": "34197498", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-13032"}], "notes": [], "created": "2021-07-05T14:32:27.688Z", "modified": "2022-11-23T08:55:43.933Z"}, {"entity": "publication", "iuid": "ff2eafd2d1ff48e0a45e97bf05326aa4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff2eafd2d1ff48e0a45e97bf05326aa4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff2eafd2d1ff48e0a45e97bf05326aa4"}}, "title": "Antimicrobial Resistance & Migrants in Sweden: Poor Living Conditions Enforced by Migration Control Policies as a Risk Factor for Optimal Public Health Management.", "authors": [{"family": "Elisabeth", "given": "Mangrio", "initials": "M"}, {"family": "Maneesh", "given": "Paul-Satyaseela", "initials": "PS"}, {"family": "Katarina", "given": "Sj\u00f6gren Forss", "initials": "SF"}, {"family": "Slobodan", "given": "Zdravkovic", "initials": "Z"}, {"family": "Michael", "given": "Strange", "initials": "S"}], "type": "journal article", "published": "2021-07-01", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "642983", "issn-l": "2296-2565"}, "abstract": "Infectious diseases exacerbated by Antimicrobial Resistance (AMR) are of increasing concern in Sweden, with multi-drug resistant strains associated with new resistance mechanisms that are emerging and spreading worldwide. Existing research has identified that sub-optimal living conditions and poor access to healthcare are significant factors in the spread and incubation of AMR strains. The article considers this linkage and the effort to control the spread of AMR in relation to migrants, highlighting deficiencies in public policy where such individuals are often increasingly exposed to those conditions that exacerbate AMR. In many of the richest countries, those conditions are not accidental, but often direct goals of policies designed with the goal of deterring migrants from staying within host countries. Without engaging with the politics around migration control, the article points to urgent need for more holistic assessment of all public policies that may, however unintentionally, undermine AMR control through worsening living conditions for vulnerable groups. The consequences of prioritizing policies meant to deliberately worsen the living conditions of migrants over avoiding those conditions that accelerate AMR spread, are today made ever apparent where new AMR strains have the potential to dwarf the societal effects of the current Covid-19 pandemic.", "doi": "10.3389/fpubh.2021.642983", "pmid": "34277534", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8281056"}], "notes": [], "created": "2021-08-05T11:13:39.031Z", "modified": "2021-08-05T11:14:00.826Z"}, {"entity": "publication", "iuid": "5392c61b27ca4aa7a750555622e66d75", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5392c61b27ca4aa7a750555622e66d75.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5392c61b27ca4aa7a750555622e66d75"}}, "title": "A Biased Analysis of the Swedish Management of Covid-19.", "authors": [{"family": "Nilson", "given": "Finn", "initials": "F"}], "type": "journal article", "published": "2021-07-01", "journal": {"title": "Health Policy Technol", "issn": "2211-8837", "pages": "100542", "issn-l": null}, "abstract": null, "doi": "10.1016/j.hlpt.2021.100542", "pmid": "34226863", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2211-8837(21)00065-4"}, {"db": "pmc", "key": "PMC8245297"}], "notes": [], "created": "2021-08-06T08:40:52.431Z", "modified": "2021-08-06T08:40:52.442Z"}, {"entity": "publication", "iuid": "1513bb866e3e43a8874229b2b52a121b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1513bb866e3e43a8874229b2b52a121b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1513bb866e3e43a8874229b2b52a121b"}}, "title": "Waterborne outbreak in a rural area in Greece during the COVID-19 pandemic: contribution of community pharmacies.", "authors": [{"family": "Mellou", "given": "Kassiani", "initials": "K"}, {"family": "Sideroglou", "given": "Theologia", "initials": "T"}, {"family": "Kefaloudi", "given": "Chrysovalanti", "initials": "C"}, {"family": "Tryfinopoulou", "given": "Kyriaki", "initials": "K"}, {"family": "Chrysostomou", "given": "Anthi", "initials": "A"}, {"family": "Mandilara", "given": "Georgia", "initials": "G"}, {"family": "Pavlaki", "given": "Maria", "initials": "M"}, {"family": "Maltezou", "given": "Helena C", "initials": "HC"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Rural Remote Health", "issn": "1445-6354", "volume": "21", "issue": "3", "pages": "6630", "issn-l": null}, "abstract": "On 15 June 2020, the National Public Health Organization was informed about the identification of two cases of Escherichia coli &Omicron;157 infection in a small town in the Peloponnese Region in Greece and we suspected an outbreak.\n\nWe asked the local pharmacist to assist us to verify the outbreak by providing the daily number of over-the-counter anti-diarrheal drugs sold from 20 May 2020 onwards. The pharmacist asked customers with gastroenteritis to submit stool samples at the local hospital. Samples were tested for 22 pathogens. We conducted a 1 : 1 case-control study. Cases and controls were retrieved from the pharmacy client list. Chlorination records of the water supply system were retrieved, and water samples were tested for microbiological indicators and viruses.\n\nThe increased number of sales of anti-diarrheal drugs verified the outbreak. Overall, 58 cases and 57 controls were recruited for the study. Tap water consumption (odds ratio (OR)=10.9, 95% confidence interval (CI)=3.1-38.0, p<0.001) and consumption of ice cubes made from tap water (OR=39.3, 95%CI=10.3-150.9, p<0.001) were independently associated with gastroenteritis occurrence. Eleven stool samples were tested; one was positive for shigatoxin-producing E. coli, one for enteropathogenic E. coli, four for E. coli O157 and one for Salmonella spp. Four samples tested negative. Five water samples collected on 18 June tested negative. The residual chlorine on 5 and 14 June ranged from 0.12 mg/L to 0.14 mg/L.\n\nThis was the first investigation of a waterborne outbreak in Greece performed with the collaboration of a local pharmacy. The COVID-19 pandemic favored the use of alternative resources and channels of communication with the local population, which can also be used in the future, especially in remote areas of the country.", "doi": "10.22605/RRH6630", "pmid": "34320325", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6630"}], "notes": [], "created": "2021-08-05T06:46:48.191Z", "modified": "2021-08-05T06:47:13.916Z"}, {"entity": "publication", "iuid": "9fdc18bf13a640e587387b79dde9daad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9fdc18bf13a640e587387b79dde9daad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9fdc18bf13a640e587387b79dde9daad"}}, "title": "Vaccine effectiveness against symptomatic SARS-CoV-2 infection in adults aged 65 years and older in primary care: I-MOVE-COVID-19 project, Europe, December 2020 to May 2021.", "authors": [{"family": "Kissling", "given": "Esther", "initials": "E"}, {"family": "Hooiveld", "given": "Mariette", "initials": "M"}, {"family": "Sandonis Mart\u00edn", "given": "Virginia", "initials": "V"}, {"family": "Mart\u00ednez-Baz", "given": "Iv\u00e1n", "initials": "I"}, {"family": "William", "given": "Naoma", "initials": "N"}, {"family": "Vilcu", "given": "Ana-Maria", "initials": "AM"}, {"family": "Mazagatos", "given": "Clara", "initials": "C"}, {"family": "Domegan", "given": "Lisa", "initials": "L"}, {"family": "de Lusignan", "given": "Simon", "initials": "S"}, {"family": "Meijer", "given": "Adam", "initials": "A"}, {"family": "Machado", "given": "Ausenda", "initials": "A"}, {"family": "Brytting", "given": "Mia", "initials": "M"}, {"family": "Casado", "given": "Itziar", "initials": "I"}, {"family": "Murray", "given": "Josephine-L K", "initials": "JK"}, {"family": "Belhillil", "given": "Sylvie", "initials": "S"}, {"family": "Larrauri", "given": "Amparo", "initials": "A"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}, {"family": "Tsang", "given": "Ruby", "initials": "R"}, {"family": "de Lange", "given": "Marit", "initials": "M"}, {"family": "Rodrigues", "given": "Ana Paula", "initials": "AP"}, {"family": "Riess", "given": "Maximilian", "initials": "M"}, {"family": "Castilla", "given": "Jes\u00fas", "initials": "J"}, {"family": "Hamilton", "given": "Mark", "initials": "M"}, {"family": "Falchi", "given": "Alessandra", "initials": "A"}, {"family": "Pozo", "given": "Francisco", "initials": "F"}, {"family": "Dunford", "given": "Linda", "initials": "L"}, {"family": "Cogdale", "given": "Jade", "initials": "J"}, {"family": "Jansen", "given": "Tessa", "initials": "T"}, {"family": "Guiomar", "given": "Raquel", "initials": "R"}, {"family": "Enkirch", "given": "Theresa", "initials": "T"}, {"family": "Burgui", "given": "Cristina", "initials": "C"}, {"family": "Sigerson", "given": "Debbie", "initials": "D"}, {"family": "Blanchon", "given": "Thierry", "initials": "T"}, {"family": "Mart\u00ednez Ochoa", "given": "Eva Mar\u00eda", "initials": "EM"}, {"family": "Connell", "given": "Jeff", "initials": "J"}, {"family": "Ellis", "given": "Joanna", "initials": "J"}, {"family": "van Gageldonk-Lafeber", "given": "Rianne", "initials": "R"}, {"family": "Kislaya", "given": "Irina", "initials": "I"}, {"family": "Rose", "given": "Angela Mc", "initials": "AM"}, {"family": "Valenciano", "given": "Marta", "initials": "M"}, {"family": "I-MOVE-COVID-19 primary care study team", "given": "", "initials": ""}, {"family": "I-MOVE-COVID-19 primary care study team (in addition to authors above)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "29", "issn-l": null}, "abstract": "We measured COVID-19 vaccine effectiveness (VE) against symptomatic SARS-CoV-2 infection at primary care/outpatient level among adults \u2265 65 years old using a multicentre test-negative design in eight European countries. We included 592 SARS-CoV-2 cases and 4,372 test-negative controls in the main analysis. The VE was 62% (95% CI: 45-74) for one dose only and 89% (95% CI: 79-94) for complete vaccination. COVID-19 vaccines provide good protection against COVID-19 presentation at primary care/outpatient level, particularly among fully vaccinated individuals.", "doi": "10.2807/1560-7917.ES.2021.26.29.2100670", "pmid": "34296676", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8299744"}], "notes": [], "created": "2021-08-05T07:11:21.985Z", "modified": "2021-08-05T07:11:21.998Z"}, {"entity": "publication", "iuid": "cbf18a605ecd4c1da82f040646d0ddc0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cbf18a605ecd4c1da82f040646d0ddc0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cbf18a605ecd4c1da82f040646d0ddc0"}}, "title": "The risk for a new COVID-19 wave and how it depends on R 0, the current immunity level and current restrictions.", "authors": [{"family": "Britton", "given": "Tom", "initials": "T", "orcid": "0000-0002-9228-7357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3953e83bbffb428ab0a02f335979acb2.json"}}, {"family": "Trapman", "given": "Pieter", "initials": "P", "orcid": "0000-0003-0569-1659", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a2df9c9216143cd8219de8687414709.json"}}, {"family": "Ball", "given": "Frank", "initials": "F"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "R Soc Open Sci", "issn": "2054-5703", "issn-l": null, "volume": "8", "issue": "7", "pages": "210386"}, "abstract": "The COVID-19 pandemic has hit different regions differently. The current disease-induced immunity level \u00ee in a region approximately equals the cumulative fraction infected, which primarily depends on two factors: (i) the initial potential for COVID-19 in the region (R 0), and (ii) the preventive measures put in place. Using a mathematical model including heterogeneities owing to age, social activity and susceptibility, and allowing for time-varying preventive measures, the risk for a new epidemic wave and its doubling time are investigated. Focus lies on quantifying the minimal overall effect of preventive measures p Min needed to prevent a future outbreak. It is shown that \u00ee plays a more influential roll than when immunity is obtained from vaccination. Secondly, by comparing regions with different R 0 and \u00ee it is shown that regions with lower R 0 and low \u00ee may need higher preventive measures (p Min) compared with regions having higher R 0 but also higher \u00ee, even when such immunity levels are far from herd immunity. Our results are illustrated on different regions but these comparisons contain lots of uncertainty due to simplistic model assumptions and insufficient data fitting, and should accordingly be interpreted with caution.", "doi": "10.1098/rsos.210386", "pmid": "34350017", "labels": {"Funder: VR": null, "Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8316802"}, {"db": "pii", "key": "rsos210386"}, {"db": "figshare", "key": "10.6084/m9.figshare.c.5526951"}], "notes": [], "created": "2021-08-06T08:58:06.739Z", "modified": "2023-06-19T15:26:02.530Z"}, {"entity": "publication", "iuid": "a2ad894923084e0981b07ac6b16d99fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2ad894923084e0981b07ac6b16d99fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2ad894923084e0981b07ac6b16d99fc"}}, "title": "The Swedish public health response to COVID-19.", "authors": [{"family": "Tegnell", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "APMIS", "issn": "1600-0463", "volume": "129", "issue": "7", "pages": "320-323", "issn-l": null}, "abstract": "The Swedish COVID-19 response has received excessive attention, despite not having distinctively different goals or features than other countries. The overall response has included almost all sectors of society and cannot be described here. Instead, this paper provides a general, brief description of the response from a public health perspective, but hopefully it gives a somewhat more nuanced picture of the efforts to combat COVID-19 in Sweden.", "doi": "10.1111/apm.13112", "pmid": "33622025", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-25T12:27:51.068Z", "modified": "2023-01-13T13:48:34.318Z"}, {"entity": "publication", "iuid": "eb63c9661b144436af10c6bf0224e8e3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb63c9661b144436af10c6bf0224e8e3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb63c9661b144436af10c6bf0224e8e3"}}, "title": "Sustained prothrombotic changes in convalescent patients with COVID-19.", "authors": [{"family": "von Meijenfeldt", "given": "Fien A", "initials": "FA"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Lisman", "given": "Ton", "initials": "T"}], "type": "letter", "published": "2021-07-00", "journal": {"title": "Lancet Haematol", "issn": "2352-3026", "issn-l": null, "volume": "8", "issue": "7", "pages": "e475"}, "abstract": null, "doi": "10.1016/S2352-3026(21)00146-0", "pmid": "34171275", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2352-3026(21)00146-0"}], "notes": [], "created": "2021-06-28T17:59:24.200Z", "modified": "2021-06-28T17:59:50.081Z"}, {"entity": "publication", "iuid": "7f1ddb4d277a4da6a35521c3b9c47ae6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f1ddb4d277a4da6a35521c3b9c47ae6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f1ddb4d277a4da6a35521c3b9c47ae6"}}, "title": "Spatial clustering and contextual factors associated with hospitalisation and deaths due to COVID-19 in Sweden: a geospatial nationwide ecological study.", "authors": [{"family": "Fonseca-Rodr\u00edguez", "given": "Osvaldo", "initials": "O", "orcid": "0000-0002-0253-5928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52ff35d4b27c4150984ca0428976d442.json"}}, {"family": "Gustafsson", "given": "Per E", "initials": "PE"}, {"family": "San Sebasti\u00e1n", "given": "Miguel", "initials": "M"}, {"family": "Connolly", "given": "Anne-Marie Fors", "initials": "AF", "orcid": "0000-0001-9215-4047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff46cc7d9e374929a14350748727ba60.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "7", "issn-l": "2059-7908"}, "abstract": "In Sweden, thousands of hospitalisations and deaths due to COVID-19 were reported since the pandemic started. Considering the uneven spatial distribution of those severe outcomes at the municipality level, the objective of this study was, first, to identify high-risk areas for COVID-19 hospitalisations and deaths, and second, to determine the associated contextual factors with the uneven spatial distribution of both study outcomes in Sweden.\n\nThe existences of spatial autocorrelation of the standardised incidence (hospitalisations) ratio and standardised mortality ratio were investigated using Global Moran's I test. Furthermore, we applied the retrospective Poisson spatial scan statistics to identify high-risk spatial clusters. The association between the contextual demographic and socioeconomic factors and the number of hospitalisations and deaths was estimated using a quasi-Poisson generalised additive regression model.\n\nTen high-risk spatial clusters of hospitalisations and six high-risk clusters of mortality were identified in Sweden from February 2020 to October 2020. The hospitalisations and deaths were associated with three contextual variables in a multivariate model: population density (inhabitants/km2) and the proportion of immigrants (%) showed a positive association with both outcomes, while the proportion of the population aged 65+ years (%) showed a negative association.\n\nOur study identified high-risk spatial clusters for hospitalisations and deaths due to COVID-19 and the association of population density, the proportion of immigrants and the proportion of people aged 65+ years with those severe outcomes. Results indicate where public health measures must be reinforced to improve sustained and future disease control and optimise the distribution of resources.", "doi": "10.1136/bmjgh-2021-006247", "pmid": "34321234", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-006247"}, {"db": "pmc", "key": "PMC8322019"}], "notes": [], "created": "2021-08-04T17:11:28.069Z", "modified": "2021-08-04T17:11:28.132Z"}, {"entity": "publication", "iuid": "b7fbc9a0406640b780703af116bba012", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b7fbc9a0406640b780703af116bba012.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b7fbc9a0406640b780703af116bba012"}}, "title": "Spanish telemedicine data on 8 children support concept of \u2018long covid\u2019 in children", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "journal-article", "published": "2021-07-00", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "issn-l": null, "volume": "110", "issue": "7", "pages": "2284-2284"}, "abstract": "I would like to thank Drs L\u00f3pez, Grasa, Calvo and L\u00f3pez-Hortelano for their informative letter (1) where they comment on my recent paper about five children with suggested long covid (2), but also draw our attention to their Spanish-language paper on Telemedicine follow-ups for COVID-19 (3). Of note their letter in Acta Paediatrica (1) confirms that long covid often occurs in pre-adolescent and adolescent children.", "doi": "10.1111/apa.15869", "pmid": "33834529", "labels": {"Type: Other": null, "Category: Post-COVID": null}, "xrefs": [], "notes": [], "created": "2021-04-12T16:13:11.496Z", "modified": "2021-07-09T12:48:42.931Z"}, {"entity": "publication", "iuid": "d7f367ada0b544c4bc6ce0f725c010fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d7f367ada0b544c4bc6ce0f725c010fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d7f367ada0b544c4bc6ce0f725c010fc"}}, "title": "Simultaneous detection of SARS-CoV-2 and pandemic (H1N1) 2009 virus with real-time isothermal platform.", "authors": [{"family": "Yu", "given": "Lin", "initials": "L"}, {"family": "Wang", "given": "Jingyao", "initials": "J"}, {"family": "Li", "given": "Xuelong", "initials": "X"}, {"family": "Mao", "given": "Lingling", "initials": "L"}, {"family": "Sui", "given": "Yi", "initials": "Y"}, {"family": "Chen", "given": "Weihua", "initials": "W"}, {"family": "Pelechano", "given": "Vicent", "initials": "V"}, {"family": "Guo", "given": "Xing", "initials": "X"}, {"family": "Yin", "given": "Xiushan", "initials": "X"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "issn-l": null, "volume": "7", "issue": "7", "pages": "e07584"}, "abstract": "The recent ongoing outbreak of novel coronavirus SARS-CoV-2 (known as COVID-19) is a severe threat to human health worldwide. By press time, more than 3.3 million people have died from COVID-19, with many countries experiencing peaks in infections and hospitalizations. The main symptoms of infection with SARS-CoV-2 include fever, chills, coughing, shortness of breath or difficulty breathing, fatigue, muscle or body aches and pains. While the symptoms of the pandemic (H1N1) 2009 virus have many similarities to the signs and transmission routes of the novel coronavirus, e.g., fever, cough, sore throat, body aches, headache, chills and fatigue. And a few cases of serious illness, rapid progress, can appear viral pneumonia, combined with respiratory failure, multiple organ function damage, serious people can die. Therefore, there is an urgent need to develop a rapid and accurate field diagnostic method to effectively identify the two viruses and treat these early infections on time, thus helping to control the spread of the disease. Among molecular detection methods, RT-LAMP (real-time reverse transcription-loop-mediated isothermal amplification) has some advantages in pathogen detection due to its rapid, accurate and effective detection characteristics. Here, we combined the primers of the two viruses with the fluorescent probes on the RT-LAMP detection platform to detect the two viruses simultaneously. Firstly, RT-LAMP method was used respectively to detect the two viruses at different concentrations to determine the effectiveness and sensitivity of probe primers to the RNA samples. And then, the two virus samples were detected simultaneously in the same reaction tube to validate if testing for the two viruses together had an impact on the results compared to detecting alone. We verified the detection efficiency of three highly active BST variants during RT-LAMP assay. We expect that this assay can effectively and accurately distinguish COVID-19 from the pandemic (H1N1) 2009, so that these two diseases with similar symptoms can be appropriately differentiated and treated.", "doi": "10.1016/j.heliyon.2021.e07584", "pmid": "34307953", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)01687-X"}, {"db": "pmc", "key": "PMC8280398"}], "notes": [], "created": "2021-08-05T06:56:22.572Z", "modified": "2021-08-05T07:01:34.728Z"}, {"entity": "publication", "iuid": "912d74dcafbe4e84bf11743a4fb0450e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/912d74dcafbe4e84bf11743a4fb0450e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/912d74dcafbe4e84bf11743a4fb0450e"}}, "title": "Severe COVID-19 in an APS1 patient with interferon autoantibodies treated with plasmapheresis", "authors": [{"family": "Lemarquis", "given": "Andri", "initials": "A", "orcid": "0000-0001-5165-0247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e10a68ac18214c00b65b4588c115c154.json"}}, {"family": "Campbell", "given": "Tessa", "initials": "T"}, {"family": "Aranda-Guill\u00e9n", "given": "Maribel", "initials": "M"}, {"family": "Hennings", "given": "Viktoria", "initials": "V"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Wenner\u00e5s", "given": "Christine", "initials": "C"}, {"family": "Eriksson", "given": "Kristina", "initials": "K"}, {"family": "Landegren", "given": "Nils", "initials": "N"}, {"family": "Bryceson", "given": "Yenan", "initials": "Y"}, {"family": "Berg", "given": "Stefan", "initials": "S"}, {"family": "Ekwall", "given": "Olov", "initials": "O"}], "type": "journal-article", "published": "2021-07-00", "journal": {"title": "J Allergy Clin Immunol", "issn": "0091-6749", "issn-l": null, "volume": "148", "issue": "1", "pages": "96-98"}, "abstract": null, "doi": "10.1016/j.jaci.2021.03.034", "pmid": "33892926", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0091-6749(21)00556-X"}, {"db": "pmc", "key": "PMC8051851"}], "notes": [], "created": "2021-04-26T17:31:01.538Z", "modified": "2021-11-18T16:08:38.815Z"}, {"entity": "publication", "iuid": "7f22600d9ed0435997c36604a4027b70", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f22600d9ed0435997c36604a4027b70.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f22600d9ed0435997c36604a4027b70"}}, "title": "Resetting the agenda for antibiotic resistance through a health systems perspective.", "authors": [{"family": "Cars", "given": "Otto", "initials": "O"}, {"family": "Chandy", "given": "Sujith J", "initials": "SJ"}, {"family": "Mpundu", "given": "Mirfin", "initials": "M"}, {"family": "Peralta", "given": "Arturo Quizhpe", "initials": "AQ"}, {"family": "Zorzet", "given": "Anna", "initials": "A"}, {"family": "So", "given": "Anthony D", "initials": "AD"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Lancet Glob Health", "issn": "2214-109X", "volume": "9", "issue": "7", "pages": "e1022-e1027", "issn-l": null}, "abstract": "Although the individual and societal consequences of antibiotic resistance spiral upwards, coordinated action has not kept pace on a global scale. The COVID-19 pandemic has highlighted the need for resilient health systems and has resulted in an unprecedented rate of collaboration in scientific, medical, social, and political dimensions. The pandemic has also created a renewed awareness of the importance of infectious diseases and is a substantial entry point for reigniting the momentum towards containing the silent pandemic of antibiotic resistance. In this Viewpoint, we discuss the limitations in the current narrative on antibiotic resistance and how it could be improved, including concerted efforts to close essential data gaps. We discuss the need for capacity building and coordination at the national and global levels to strengthen the understanding of the importance of sustainable access to effective antibiotics for all health systems that could generate tangible links to current processes for global health and development.", "doi": "10.1016/S2214-109X(21)00163-7", "pmid": "34143980", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2214-109X(21)00163-7"}], "notes": [], "created": "2021-06-28T18:29:27.689Z", "modified": "2021-06-28T18:29:27.705Z"}, {"entity": "publication", "iuid": "edac061672b844fc99698b5d8cd78b4f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/edac061672b844fc99698b5d8cd78b4f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/edac061672b844fc99698b5d8cd78b4f"}}, "title": "Rapid diagnostic testing for SARS-CoV-2: Validation and comparison of three point-of-care antibody tests.", "authors": [{"family": "Strand", "given": "Rasmus", "initials": "R", "orcid": "0000-0002-6875-6790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32fd1184e1274c21a16cb67f4a5000de.json"}}, {"family": "Thelaus", "given": "Louise", "initials": "L"}, {"family": "Fernstr\u00f6m", "given": "Nils", "initials": "N"}, {"family": "Sunnerhagen", "given": "Torgny", "initials": "T"}, {"family": "Lindroth", "given": "Ylva", "initials": "Y"}, {"family": "Linder", "given": "Adam", "initials": "A"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "J Med Virol", "issn": "1096-9071", "volume": "93", "issue": "7", "pages": "4592-4596", "issn-l": null}, "abstract": "With the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a need for diagnostic tests has surfaced. Point-of-care (POC) antibody tests can detect immunoglobulin (Ig) G and M against SARS-CoV-2 in serum, plasma, or whole blood and give results within 15 min. Validation of the performance of such tests is needed if they are to be used in clinical practice. In this study, we evaluated three POC antibody tests. Convalescent serum samples from 47 reverse transcription-polymerase chain reaction (RT-PCR) verified patients with coronavirus disease 2019 (COVID-19) collected at least 28 days post RT-PCR diagnosis as well as 50 negative pre-COVID-19 controls were tested. The three tests (denoted the J-, N-, and Z-tests) displayed the sensitivities of 87%, 96%, and 85%, respectively, for the detection of IgG. All tests had the same specificity for IgG (98%). The tests did not differ significantly for the detection of IgG. The sensitivities for IgM were lower (15%, 67%, and 70%) and the specificities were 90%, 98%, and 90%, respectively. The positive and negative predictive values were similar among the tests. Our results indicate that these POC antibody tests might be accurate enough to use in routine clinical practice.", "doi": "10.1002/jmv.26913", "pmid": "33666238", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Proteins": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8014463"}], "notes": [], "created": "2021-03-06T10:09:55.362Z", "modified": "2021-11-18T12:47:58.452Z"}, {"entity": "publication", "iuid": "f1262619e94340d4ab08c02d5fd8f36d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1262619e94340d4ab08c02d5fd8f36d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1262619e94340d4ab08c02d5fd8f36d"}}, "title": "Privacy lost: Appropriating surveillance technology in China\u2019s fight against COVID-19", "authors": [{"family": "Liu", "given": "Jun", "initials": "J"}, {"family": "Zhao", "given": "Hui", "initials": "H"}], "type": "journal-article", "published": "2021-07-00", "journal": {"title": "Business Horizons", "issn": "0007-6813", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/j.bushor.2021.07.004", "pmid": null, "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:52:59.576Z", "modified": "2022-11-23T08:58:55.620Z"}, {"entity": "publication", "iuid": "18aa9fe62d094bfabc8c44c5c3a5e5de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18aa9fe62d094bfabc8c44c5c3a5e5de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18aa9fe62d094bfabc8c44c5c3a5e5de"}}, "title": "Monitoring lung injury with particle flow rate in LPS- and COVID-19-induced ARDS.", "authors": [{"family": "Stenlo", "given": "Martin", "initials": "M", "orcid": "0000-0001-8328-259X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/194fa048a20b4e149737bd062773b293.json"}}, {"family": "Silva", "given": "Iran A N", "initials": "IAN"}, {"family": "Hyll\u00e9n", "given": "Snejana", "initials": "S"}, {"family": "B\u00f6l\u00fckbas", "given": "Deniz A", "initials": "DA"}, {"family": "Niroomand", "given": "Anna", "initials": "A", "orcid": "0000-0002-6402-9414", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ce75bcb9bac481f93e200ea079812b4.json"}}, {"family": "Grins", "given": "Edgars", "initials": "E"}, {"family": "Ederoth", "given": "Per", "initials": "P"}, {"family": "Hallgren", "given": "Oskar", "initials": "O"}, {"family": "Pierre", "given": "Leif", "initials": "L"}, {"family": "Wagner", "given": "Darcy E", "initials": "DE", "orcid": "0000-0003-3794-1309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a62680154e2e4ae2b7cec2c44af06c9a.json"}}, {"family": "Lindstedt", "given": "Sandra", "initials": "S", "orcid": "0000-0003-4484-6473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0739b93800374fa789184d52aa753ffa.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Physiol Rep", "issn": "2051-817X", "volume": "9", "issue": "13", "pages": "e14802", "issn-l": null}, "abstract": "In severe acute respiratory distress syndrome (ARDS), extracorporeal membrane oxygenation (ECMO) is a life-prolonging treatment, especially among COVID-19 patients. Evaluation of lung injury progression is challenging with current techniques. Diagnostic imaging or invasive diagnostics are risky given the difficulties of intra-hospital transportation, contraindication of biopsies, and the potential for the spread of infections, such as in COVID-19 patients. We have recently shown that particle flow rate (PFR) from exhaled breath could be a noninvasive, early detection method for ARDS during mechanical ventilation. We hypothesized that PFR could also measure the progress of lung injury during ECMO treatment. Lipopolysaccharide (LPS) was thus used to induce ARDS in pigs under mechanical ventilation. Eight were connected to ECMO, whereas seven animals were not. In addition, six animals received sham treatment with saline. Four human patients with ECMO and ARDS were also monitored. In the pigs, as lung injury ensued, the PFR dramatically increased and a particular spike followed the establishment of ECMO in the LPS-treated animals. PFR remained elevated in all animals with no signs of lung recovery. In the human patients, in the two that recovered, PFR decreased. In the two whose lung function deteriorated while on ECMO, there was increased PFR with no sign of recovery in lung function. The present results indicate that real-time monitoring of PFR may be a new, complementary approach in the clinic for measurement of the extent of lung injury and recovery over time in ECMO patients with ARDS.", "doi": "10.14814/phy2.14802", "pmid": "34250766", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8273428"}], "notes": [], "created": "2021-08-06T07:49:20.116Z", "modified": "2021-08-06T07:49:20.217Z"}, {"entity": "publication", "iuid": "f111b8fca3e6412b8110ce03ded40ceb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f111b8fca3e6412b8110ce03ded40ceb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f111b8fca3e6412b8110ce03ded40ceb"}}, "title": "Lessons from COVID.", "authors": [{"family": "Kitson", "given": "Alison", "initials": "A", "orcid": "0000-0003-3053-8381", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7dd7640c23354063aab9385f22eaf4af.json"}}, {"family": "Huisman-de Waal", "given": "Getty", "initials": "G"}, {"family": "Muntlin", "given": "Asa", "initials": "A"}], "type": "editorial", "published": "2021-07-00", "journal": {"title": "J Adv Nurs", "issn": "1365-2648", "volume": "77", "issue": "7", "pages": "e7-e9", "issn-l": null}, "abstract": null, "doi": "10.1111/jan.14844", "pmid": "33780039", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-03-30T12:25:58.304Z", "modified": "2023-01-13T13:35:08.253Z"}, {"entity": "publication", "iuid": "774079bedc1a47c5a03107c4ae2b68e4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/774079bedc1a47c5a03107c4ae2b68e4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/774079bedc1a47c5a03107c4ae2b68e4"}}, "title": "Intrauterine vertical SARS-CoV-2 infection: a case confirming transplacental transmission followed by divergence of the viral genome.", "authors": [{"family": "Zaigham", "given": "M", "initials": "M", "orcid": "0000-0003-0129-1578", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/168018c2beee4b99868263d77bb67277.json"}}, {"family": "Holmberg", "given": "A", "initials": "A"}, {"family": "Karlberg", "given": "M L", "initials": "ML"}, {"family": "Lindsj\u00f6", "given": "O K", "initials": "OK"}, {"family": "Jokubkiene", "given": "L", "initials": "L"}, {"family": "Sandblom", "given": "J", "initials": "J"}, {"family": "Strand", "given": "A S", "initials": "AS"}, {"family": "Andersson", "given": "O", "initials": "O"}, {"family": "Hansson", "given": "S R", "initials": "SR"}, {"family": "Nord", "given": "D G", "initials": "DG"}, {"family": "Tannenberg", "given": "P", "initials": "P"}], "type": "case reports", "published": "2021-07-00", "journal": {"title": "BJOG", "issn": "1471-0528", "volume": "128", "issue": "8", "pages": "1388-1394", "issn-l": null}, "abstract": "A 27-year-old woman (gravida 2, para 1) was transported to the regional university hospital in gestational week (GW) 34 + 4 due to a three-day history of fever, abdominal pain and reduced foetal movements. She had developed a dry cough one day prior to the admission (Figure S1). The woman, was slightly overweight (BMI 27 kg/m 2 ) but otherwise healthy. She had normal antenatal check-ups and an obstetric ultrasound at GW 32 + 2 showed a normal foetal weight deviation of +8%1 .", "doi": "10.1111/1471-0528.16682", "pmid": "33638908", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8013698"}], "notes": [], "created": "2021-03-01T10:26:44.679Z", "modified": "2021-11-18T11:58:29.481Z"}, {"entity": "publication", "iuid": "04206c294cbe4fceb756221db3d0b598", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/04206c294cbe4fceb756221db3d0b598.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/04206c294cbe4fceb756221db3d0b598"}}, "title": "Impact of pathogen reduction methods on immunological properties of the COVID-19 convalescent plasma.", "authors": [{"family": "Kostin", "given": "Alexander I", "initials": "AI", "orcid": "0000-0001-7542-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a28d5c0e69df478a84d89c91d83f0068.json"}}, {"family": "Lundgren", "given": "Maria N", "initials": "MN", "orcid": "0000-0001-8081-962X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8000a3de30e4a42a2397c3561adb685.json"}}, {"family": "Bulanov", "given": "Andrey Y", "initials": "AY", "orcid": "0000-0001-6999-8145", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/739b725cb6ed4bc4a39ab94fef9c0b1a.json"}}, {"family": "Ladygina", "given": "Elena A", "initials": "EA", "orcid": "0000-0001-7343-0667", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d3950fb8d5a47528353602e7f3bc81b.json"}}, {"family": "Chirkova", "given": "Karina S", "initials": "KS", "orcid": "0000-0003-2583-9956", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a8097f7620b42d8a7f0499f13e3e079.json"}}, {"family": "Gintsburg", "given": "Alexander L", "initials": "AL", "orcid": "0000-0003-1769-5059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2431d07e4df14514832bd495b68881fb.json"}}, {"family": "Logunov", "given": "Denis Y", "initials": "DY", "orcid": "0000-0003-4035-6581", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/66576c7bb29446cba136c9d019e0dfeb.json"}}, {"family": "Dolzhikova", "given": "Inna V", "initials": "IV", "orcid": "0000-0003-2548-6142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d48dc829d0346c1bf6220c25091ee47.json"}}, {"family": "Shcheblyakov", "given": "Dmitry V", "initials": "DV", "orcid": "0000-0002-1289-3411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9966082c61f4ed29f5e6e5d9416d109.json"}}, {"family": "Borovkova", "given": "Natalia V", "initials": "NV", "orcid": "0000-0002-8897-7523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eaca90ac5bf5475abf8f994e18b79402.json"}}, {"family": "Godkov", "given": "Mikhail A", "initials": "MA", "orcid": "0000-0001-9612-6705", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83b007f636504bc7a4743146e6e897cf.json"}}, {"family": "Bazhenov", "given": "Alexey I", "initials": "AI", "orcid": "0000-0002-1926-145X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a35e87f647f4945982b3077b72e038c.json"}}, {"family": "Shustov", "given": "Valeriy V", "initials": "VV", "orcid": "0000-0002-9624-5883", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74087b1795364165b659eaa9c13071a2.json"}}, {"family": "Bogdanova", "given": "Alina S", "initials": "AS", "orcid": "0000-0002-6608-8493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04f6332b01c24d709ebffc160911f661.json"}}, {"family": "Kamalova", "given": "Alina R", "initials": "AR", "orcid": "0000-0001-8022-8491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1664eb55ddfd44f78a90ecfa31e61603.json"}}, {"family": "Ganchin", "given": "Vladimir V", "initials": "VV", "orcid": "0000-0001-9138-6479", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8282794964834c2f818f8622f18931f5.json"}}, {"family": "Dombrovskiy", "given": "Eugene A", "initials": "EA", "orcid": "0000-0002-3154-3564", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/416da0dc54b642158bfa85aff8763979.json"}}, {"family": "Volkov", "given": "Stanislav E", "initials": "SE", "orcid": "0000-0001-5289-2256", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b60e88f4ce9740b0ad315065b9fce6c5.json"}}, {"family": "Drozdova", "given": "Nataliya E", "initials": "NE", "orcid": "0000-0001-9374-6554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bac7ac296eb942a884f56fe03d385c01.json"}}, {"family": "Petrikov", "given": "Sergey S", "initials": "SS", "orcid": "0000-0003-3292-8789", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d28e63ecffcc469ca8f1bc5ec08d392b.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Vox Sang", "issn": "1423-0410", "volume": "116", "issue": "6", "pages": "665-672", "issn-l": null}, "abstract": "COVID-19 convalescent plasma is an experimental treatment against SARS-CoV-2. The aim of this study is to assess the impact of different pathogen reduction methods on the levels and virus neutralizing activity of the specific antibodies against SARS-CoV2 in convalescent plasma.\n\nA total of 140 plasma doses collected by plasmapheresis from COVID-19 convalescent donors were subjected to pathogen reduction by three methods: methylene blue (M)/visible light, riboflavin (R)/UVB and amotosalen (A)/UVA. To conduct a paired comparison, individual plasma doses were divided into 2 samples that were subjected to one of these methods. The titres of SARS-CoV2 neutralizing antibodies (NtAbs) and levels of specific immunoglobulins to RBD, S- and N-proteins of SARS-CoV-2 were measured before and after pathogen reduction.\n\nThe methods reduced NtAbs titres differently: among units with the initial titre 80 or above, 81% of units remained unchanged and 19% decreased by one step after methylene blue; 60% were unchanged and 40% decreased by one step after amotosalen; after riboflavin 43% were unchanged and 50% (7%, respectively) had a one-step (two-step, respectively) decrease. Paired two-sample comparisons (M vs. A, M vs. R and A vs. R) revealed that the largest statistically significant decrease in quantity and activity of the specific antibodies resulted from the riboflavin treatment.\n\nPathogen reduction with methylene blue or with amotosalen provides the greater likelihood of preserving the immunological properties of the COVID-19 convalescent plasma compared to riboflavin.", "doi": "10.1111/vox.13056", "pmid": "33734455", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8250394"}], "notes": [], "created": "2021-03-22T10:49:56.136Z", "modified": "2021-11-18T13:46:53.300Z"}, {"entity": "publication", "iuid": "5961f60ecefc450babce1e2642161dc1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5961f60ecefc450babce1e2642161dc1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5961f60ecefc450babce1e2642161dc1"}}, "title": "Higher vs lower doses of dexamethasone in patients with COVID\u201019 and severe hypoxia (COVID STEROID 2) trial: Protocol and statistical analysis plan", "authors": [{"family": "Munch", "given": "MW", "initials": "M", "orcid": "0000-0003-1127-9599", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd56f64f991042da935f6f3836e087b0.json"}}, {"family": "Granholm", "given": "Anders", "initials": "A"}, {"family": "Myatra", "given": "SN", "initials": "S"}, {"family": "Vijayaraghavan", "given": "BKT", "initials": "B"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Wahlin", "given": "RR", "initials": "R"}, {"family": "Jakob", "given": "Stephan M", "initials": "SM"}, {"family": "Cioccari", "given": "Luca", "initials": "L"}, {"family": "Kj\u00e6r", "given": "MN", "initials": "M", "orcid": "0000-0002-6536-0504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df8fa07399b448a5b689089e505dab58.json"}}, {"family": "Vesterlund", "given": "GK", "initials": "G", "orcid": "0000-0001-5221-3938", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6eb5ff4bc5054887bfac267b8c8af411.json"}}, {"family": "Meyhoff", "given": "TS", "initials": "T", "orcid": "0000-0002-1840-1596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/766fe5fd044944faabf6a96e8d6a72f0.json"}}, {"family": "Helleberg", "given": "Marie", "initials": "M"}, {"family": "M\u00f8ller", "given": "MH", "initials": "M", "orcid": "0000-0002-6378-9673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1cf88aaa5c9436a8e70ddfe39cfe4e8.json"}}, {"family": "Benfield", "given": "Thomas", "initials": "T"}, {"family": "Venkatesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Hammond", "given": "Naomi", "initials": "N"}, {"family": "Micallef", "given": "Sharon", "initials": "S"}, {"family": "Bassi", "given": "Abhinav", "initials": "A"}, {"family": "John", "given": "Oommen", "initials": "O"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Kristiansen", "given": "KT", "initials": "K"}, {"family": "Ulrik", "given": "CS", "initials": "C"}, {"family": "J\u00f8rgensen", "given": "VL", "initials": "V"}, {"family": "Smitt", "given": "Margit", "initials": "M"}, {"family": "Bestle", "given": "Morten H", "initials": "MH"}, {"family": "Andreasen", "given": "AS", "initials": "A"}, {"family": "Poulsen", "given": "LM", "initials": "L"}, {"family": "Rasmussen", "given": "BS", "initials": "B", "orcid": "0000-0003-2190-145X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa66146077394afea60f71d4be6daf06.json"}}, {"family": "Br\u00f8chner", "given": "AC", "initials": "A"}, {"family": "Str\u00f8m", "given": "Thomas", "initials": "T"}, {"family": "M\u00f8ller", "given": "Anders", "initials": "A"}, {"family": "Khan", "given": "MS", "initials": "M"}, {"family": "Padmanaban", "given": "Ajay", "initials": "A"}, {"family": "Divatia", "given": "JV", "initials": "J"}, {"family": "Saseedharan", "given": "Sanjith", "initials": "S"}, {"family": "Borawake", "given": "Kapil", "initials": "K"}, {"family": "Kapadia", "given": "Farhad", "initials": "F"}, {"family": "Dixit", "given": "Subhal", "initials": "S"}, {"family": "Chawla", "given": "Rajesh", "initials": "R"}, {"family": "Shukla", "given": "Urvi", "initials": "U"}, {"family": "Amin", "given": "Pravin", "initials": "P"}, {"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Lange", "given": "Theis", "initials": "T"}, {"family": "Perner", "given": "Anders", "initials": "A", "orcid": "0000-0002-4668-0123", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5d5120bc69c433f9df2b929d6be905a.json"}}], "type": "journal-article", "published": "2021-07-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "0001-5172", "volume": "65", "issue": "6", "pages": "834-845", "issn-l": null}, "abstract": null, "doi": "10.1111/aas.13795", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-15T07:49:08.383Z", "modified": "2021-06-18T12:04:56.569Z"}, {"entity": "publication", "iuid": "f2856ad6b78843f286c681e2ad60aa62", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f2856ad6b78843f286c681e2ad60aa62.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f2856ad6b78843f286c681e2ad60aa62"}}, "title": "Gambling and self-reported changes in gambling during COVID-19 in web survey respondents in Denmark.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": "7", "issue": "7", "pages": "e07506", "issn-l": null}, "abstract": "Problem gambling is among the public health hazards which may increase due to the COVID-19 pandemic and its consequences on society. Results from a few countries have hitherto been diverse with respect to gambling during the pandemic. The present study aimed to study gambling behaviors during COVID-19 in Denmark, with the same methodology as previously used in Sweden, and also to provide a comparison to previously published Swedish data. A web survey was answered by 2,012 individuals, from December 2, to December 10, 2020. Four percent reported increased gambling habits, and three percent reported decreased gambling, during COVID-19. Self-reported increase in gambling was associated with spending more time at home, mental distress, and higher gambling severity. Prevalence of self-reported, increased gaming during COVID-19 was significantly lower in Denmark than in Sweden. Although the overall changes in gambling patterns during COVID-19 may be limited, people who increase their gambling during the pandemic may be at particular risk. Stakeholders should pay attention to individuals who report altered gambling habits during the pandemic.", "doi": "10.1016/j.heliyon.2021.e07506", "pmid": "34337174", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)01609-1"}, {"db": "pmc", "key": "PMC8318852"}], "notes": [], "created": "2021-08-04T10:11:54.307Z", "modified": "2021-08-04T10:12:15.975Z"}, {"entity": "publication", "iuid": "97ef8fbfc7b64b0b847e5d76a17538e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/97ef8fbfc7b64b0b847e5d76a17538e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/97ef8fbfc7b64b0b847e5d76a17538e1"}}, "title": "Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry.", "authors": [{"family": "Strangfeld", "given": "Anja", "initials": "A", "orcid": "0000-0002-6233-022X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/644005e83dff44b7bdca5d2b818e17d5.json"}}, {"family": "Sch\u00e4fer", "given": "Martin", "initials": "M"}, {"family": "Gianfrancesco", "given": "Milena A", "initials": "MA"}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S"}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Ljung", "given": "Lotta", "initials": "L", "orcid": "0000-0001-8999-0925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/709689ef8ef54a80a79c7db9ad2d9de8.json"}}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Richez", "given": "Christophe", "initials": "C", "orcid": "0000-0002-3029-8739", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eade13f96ed49bd8a656c07a8f6ced8.json"}}, {"family": "Santos", "given": "Maria J", "initials": "MJ", "orcid": "0000-0002-7946-1365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d031d58f434247fd83359ee0c7602db5.json"}}, {"family": "Schmajuk", "given": "Gabriela", "initials": "G"}, {"family": "Scir\u00e8", "given": "Carlo A", "initials": "CA", "orcid": "0000-0001-7451-0271", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76ebc6c1acb94b2780a38dc4e8aea708.json"}}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA"}, {"family": "Sufka", "given": "Paul", "initials": "P"}, {"family": "Thomas", "given": "Thierry", "initials": "T"}, {"family": "Trupin", "given": "Laura", "initials": "L"}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Al-Adely", "given": "Sarah", "initials": "S"}, {"family": "Bachiller-Corral", "given": "Javier", "initials": "J", "orcid": "0000-0001-8954-209X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a1aaa97213840fe8ab9108b4574e9a5.json"}}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Cacoub", "given": "Patrice", "initials": "P"}, {"family": "Carmona", "given": "Loreto", "initials": "L", "orcid": "0000-0002-4401-2551", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/798721bfd6a14e2f95267a56c5750ebe.json"}}, {"family": "Costello", "given": "Ruth", "initials": "R", "orcid": "0000-0003-2709-6666", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c0fe69f61b54ab89f9a3de852f872a8.json"}}, {"family": "Costello", "given": "Wendy", "initials": "W"}, {"family": "Gossec", "given": "Laure", "initials": "L", "orcid": "0000-0002-4528-310X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be93914dbc9b4abb936cbcaf202de05f.json"}}, {"family": "Grainger", "given": "Rebecca", "initials": "R"}, {"family": "Hachulla", "given": "Eric", "initials": "E", "orcid": "0000-0001-7432-847X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20bee300407547bc8d669593ff7b2764.json"}}, {"family": "Hasseli", "given": "Rebecca", "initials": "R", "orcid": "0000-0002-2982-8253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aac4e1f1ceab4e72bb816a40c2f80c44.json"}}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS", "orcid": "0000-0003-0786-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d99dc166f48d4af7b8e46dc999c7444b.json"}}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL", "orcid": "0000-0001-8242-9262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9ad49b088eb467ba6d1ca1559b88047.json"}}, {"family": "Izadi", "given": "Zara", "initials": "Z"}, {"family": "Jacobsohn", "given": "Lindsay", "initials": "L"}, {"family": "Katz", "given": "Patricia", "initials": "P"}, {"family": "Kearsley-Fleet", "given": "Lianne", "initials": "L", "orcid": "0000-0003-0377-1575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9cc64aac266462baf67998b3d49c6f7.json"}}, {"family": "Robinson", "given": "Philip C", "initials": "PC", "orcid": "0000-0002-3156-3418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/950b622d31724172817ccde09902d215.json"}}, {"family": "Yazdany", "given": "Jinoos", "initials": "J"}, {"family": "Machado", "given": "Pedro M", "initials": "PM", "orcid": "0000-0002-8411-7972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef40d1eea57946e4a37d2e92a02a47cd.json"}}, {"family": "COVID-19 Global Rheumatology Alliance", "given": "", "initials": ""}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Ann Rheum Dis", "issn": "1468-2060", "volume": "80", "issue": "7", "pages": "930-942", "issn-l": null}, "abstract": "To determine factors associated with COVID-19-related death in people with rheumatic diseases.\n\nPhysician-reported registry of adults with rheumatic disease and confirmed or presumptive COVID-19 (from 24 March to 1 July 2020). The primary outcome was COVID-19-related death. Age, sex, smoking status, comorbidities, rheumatic disease diagnosis, disease activity and medications were included as covariates in multivariable logistic regression models. Analyses were further stratified according to rheumatic disease category.\n\nOf 3729 patients (mean age 57 years, 68% female), 390 (10.5%) died. Independent factors associated with COVID-19-related death were age (66-75 years: OR 3.00, 95% CI 2.13 to 4.22; >75 years: 6.18, 4.47 to 8.53; both vs \u226465 years), male sex (1.46, 1.11 to 1.91), hypertension combined with cardiovascular disease (1.89, 1.31 to 2.73), chronic lung disease (1.68, 1.26 to 2.25) and prednisolone-equivalent dosage >10 mg/day (1.69, 1.18 to 2.41; vs no glucocorticoid intake). Moderate/high disease activity (vs remission/low disease activity) was associated with higher odds of death (1.87, 1.27 to 2.77). Rituximab (4.04, 2.32 to 7.03), sulfasalazine (3.60, 1.66 to 7.78), immunosuppressants (azathioprine, cyclophosphamide, ciclosporin, mycophenolate or tacrolimus: 2.22, 1.43 to 3.46) and not receiving any disease-modifying anti-rheumatic drug (DMARD) (2.11, 1.48 to 3.01) were associated with higher odds of death, compared with methotrexate monotherapy. Other synthetic/biological DMARDs were not associated with COVID-19-related death.\n\nAmong people with rheumatic disease, COVID-19-related death was associated with known general factors (older age, male sex and specific comorbidities) and disease-specific factors (disease activity and specific medications). The association with moderate/high disease activity highlights the importance of adequate disease control with DMARDs, preferably without increasing glucocorticoid dosages. Caution may be required with rituximab, sulfasalazine and some immunosuppressants.", "doi": "10.1136/annrheumdis-2020-219498", "pmid": "33504483", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7843211"}, {"db": "pii", "key": "annrheumdis-2020-219498"}], "notes": [], "created": "2021-01-29T15:13:40.304Z", "modified": "2023-06-19T14:10:28.427Z"}, {"entity": "publication", "iuid": "facda1393fe04db9932c289dd0bcd4f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/facda1393fe04db9932c289dd0bcd4f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/facda1393fe04db9932c289dd0bcd4f0"}}, "title": "Editor's Choice - The Impact of Covid-19 on Vascular Procedures in Sweden 2020.", "authors": [{"family": "Bj\u00f6rses", "given": "Katarina", "initials": "K"}, {"family": "Blomgren", "given": "Lena", "initials": "L"}, {"family": "Holsti", "given": "Mari", "initials": "M"}, {"family": "Jonsson", "given": "Magnus", "initials": "M"}, {"family": "Smidfelt", "given": "Kristian", "initials": "K"}, {"family": "Mani", "given": "Kevin", "initials": "K"}], "type": "letter", "published": "2021-07-00", "journal": {"title": "Eur J Vasc Endovasc Surg", "issn": "1532-2165", "issn-l": "1078-5884", "volume": "62", "issue": "1", "pages": "136-137"}, "abstract": null, "doi": "10.1016/j.ejvs.2021.04.027", "pmid": "34053841", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8098046"}, {"db": "pii", "key": "S1078-5884(21)00372-5"}], "notes": [], "created": "2021-06-04T11:30:05.360Z", "modified": "2023-01-13T14:48:38.476Z"}, {"entity": "publication", "iuid": "3f5db6dd1efd4733beb5d4486525868a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f5db6dd1efd4733beb5d4486525868a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f5db6dd1efd4733beb5d4486525868a"}}, "title": "Critical illness polyneuropathy, myopathy and neuronal biomarkers in COVID-19 patients: A prospective study.", "authors": [{"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "F\u00e4llmar", "given": "David", "initials": "D"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Ashton", "given": "Nicholas", "initials": "N"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Punga", "given": "Anna Rostedt", "initials": "AR"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Clin Neurophysiol", "issn": "1872-8952", "issn-l": null, "volume": "132", "issue": "7", "pages": "1733-1740"}, "abstract": "The aim was to characterize the electrophysiological features and plasma biomarkers of critical illness polyneuropathy (CIN) and myopathy (CIM) in coronavirus disease 2019 (COVID-19) patients with intensive care unit acquired weakness (ICUAW).\n\nAn observational ICU cohort study including adult patients admitted to the ICU at Uppsala University Hospital, Uppsala, Sweden, from March 13th to June 8th 2020. We compared the clinical, electrophysiological and plasma biomarker data between COVID-19 patients who developed CIN/CIM and those who did not. Electrophysiological characteristics were also compared between COVID-19 and non-COVID-19 ICU patients.\n\n111 COVID-19 patients were included, 11 of whom developed CIN/CIM. Patients with CIN/CIM had more severe illness; longer ICU stay, more thromboembolic events and were more frequently treated with invasive ventilation for longer than 2 weeks. In particular CIN was more frequent among COVID-19 patients with ICUAW (50%) compared with a non-COVID-19 cohort (0%, p = 0.008). Neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAp) levels were higher in the CIN/CIM group compared with those that did not develop CIN/CIM (both p = 0.001) and correlated with nerve amplitudes.\n\nCIN/CIM was more prevalent among COVID-19 ICU patients with severe illness.\n\nCOVID-19 patients who later developed CIN/CIM had significantly higher NfL and GFAp in the early phase of ICU care, suggesting their potential as predictive biomarkers for CIN/CIM.", "doi": "10.1016/j.clinph.2021.03.016", "pmid": "33875374", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "S1388-2457(21)00489-2"}, {"db": "pmc", "key": "PMC8012169"}], "notes": [], "created": "2021-04-20T17:48:37.525Z", "modified": "2021-12-12T18:08:09.693Z"}, {"entity": "publication", "iuid": "c87c3f16e8944d079f1a4fa0db3fd07d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c87c3f16e8944d079f1a4fa0db3fd07d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c87c3f16e8944d079f1a4fa0db3fd07d"}}, "title": "Central pulmonary embolism in patients with Covid-19.", "authors": [{"family": "Nordberg", "given": "Martin", "initials": "M"}, {"family": "Bankler", "given": "Sara", "initials": "S"}, {"family": "Everhov", "given": "\u00c5sa H", "initials": "\u00c5H"}, {"family": "Saraste", "given": "Deborah", "initials": "D", "orcid": "0000-0002-2931-2652", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27593429159d4605b8d3835a4c479c9d.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "volume": "53", "issue": "7", "pages": "513-520", "issn-l": "2374-4235"}, "abstract": "The purpose was to evaluate central pulmonary embolism (PE) in patients with Covid-19. The association with severe radiological pulmonary changes, prophylactic anticoagulation and ICU care was assessed.\n\nFrom 1 March until 31 May 2020, all in-hospital patients with a positive PCR for SARS-CoV-2-RNA and PE diagnosed with computed tomography pulmonary angiography were identified through diagnostic codes in medical charts. PE was characterised as central/peripheral and unilateral/bilateral. Covid-19 related lung changes were evaluated scoring the proportion of affected lung (max-score score 25) for all five lobes in both lungs. ICU and non-ICU patients were included and anticoagulant regimens were assessed.\n\nOf 1162 patients with Covid-19, 41 were diagnosed with PE (cumulative incidence 3.5%), and of these 63.4% (=overall 2.2%) had central PE. PE on admission was present in 46.3%. No differences were seen in the distribution of central vs. peripheral PE in relation to prophylactic anticoagulation (p=.317). Of ICU patients 82.4% were diagnosed with central PE compared to 50.0% among non-ICU patients (p=.05). No association was observed between the presence of central PE and the extent of radiological Covid-19 changes (p=.451). Mild (0-12 p) and severe (13-25 p) pulmonary changes were seen in 63.4% and 36.6% of patients respectively.\n\nOverall, and especially in ICU-patients, a high proportion of central PE was seen and many were diagnosed at admission. No association between central PE and prophylactic anticoagulation, or the extent of pulmonary Covid-19 changes was observed.", "doi": "10.1080/23744235.2021.1896030", "pmid": "33682582", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-09T15:36:23.979Z", "modified": "2021-11-18T12:49:39.668Z"}, {"entity": "publication", "iuid": "7a1bbe984f604d3f94c80907b7a3fcd1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a1bbe984f604d3f94c80907b7a3fcd1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a1bbe984f604d3f94c80907b7a3fcd1"}}, "title": "COVIDomic: A multi-modal cloud-based platform for identification of risk factors associated with COVID-19 severity.", "authors": [{"family": "Naumov", "given": "Vladimir", "initials": "V", "orcid": "0000-0003-3863-4925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3908575922db49b385f95202accd91ab.json"}}, {"family": "Putin", "given": "Evgeny", "initials": "E", "orcid": "0000-0002-3012-9708", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75cf694692d94af78fa6d20713e4be85.json"}}, {"family": "Pushkov", "given": "Stefan", "initials": "S", "orcid": "0000-0002-1768-394X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fbbf0cd7a6a43818a2b308693edf670.json"}}, {"family": "Kozlova", "given": "Ekaterina", "initials": "E", "orcid": "0000-0003-2737-3694", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c21fab8ed9d743a0b2c898e11480003e.json"}}, {"family": "Romantsov", "given": "Konstantin", "initials": "K", "orcid": "0000-0003-0731-8575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76be3a4ea6964c7d81744a82113acde0.json"}}, {"family": "Kalashnikov", "given": "Alexander", "initials": "A"}, {"family": "Galkin", "given": "Fedor", "initials": "F", "orcid": "0000-0002-5709-9529", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/66f24623a3c14040b179ba9b0fd994ee.json"}}, {"family": "Tihonova", "given": "Nina", "initials": "N"}, {"family": "Shneyderman", "given": "Anastasia", "initials": "A"}, {"family": "Galkin", "given": "Egor", "initials": "E", "orcid": "0000-0001-9636-5706", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd7329726357486b93f9c01eb249c917.json"}}, {"family": "Zinkevich", "given": "Arsenii", "initials": "A"}, {"family": "Cope", "given": "Stephanie M", "initials": "SM"}, {"family": "Sethuraman", "given": "Ramanathan", "initials": "R"}, {"family": "Oprea", "given": "Tudor I", "initials": "TI", "orcid": "0000-0002-6195-6976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c480e6e946bd4c43ac430fd0309df71e.json"}}, {"family": "Pearson", "given": "Alexander T", "initials": "AT", "orcid": "0000-0003-2801-7456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/649fa71af7a0428fbd8f8d10111089c6.json"}}, {"family": "Tay", "given": "Savas", "initials": "S", "orcid": "0000-0002-1912-6020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d47c1f069594367b8f9169d673d1dba.json"}}, {"family": "Agrawal", "given": "Nishant", "initials": "N"}, {"family": "Dubovenko", "given": "Alexey", "initials": "A", "orcid": "0000-0002-8424-5106", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f6b0af89130473aaf4b162f743ac5a8.json"}}, {"family": "Vanhaelen", "given": "Quentin", "initials": "Q", "orcid": "0000-0002-4611-2046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e78a63ea937e424a9bc7a57023bdac7f.json"}}, {"family": "Ozerov", "given": "Ivan", "initials": "I"}, {"family": "Aliper", "given": "Alex", "initials": "A", "orcid": "0000-0002-4363-0710", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4057aed986b9489b995e45a29d47eece.json"}}, {"family": "Izumchenko", "given": "Evgeny", "initials": "E"}, {"family": "Zhavoronkov", "given": "Alex", "initials": "A", "orcid": "0000-0001-7067-8966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb35e56edd4345f3be5cc72840aaa355.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "PLoS Comput Biol", "issn": "1553-7358", "issn-l": null, "volume": "17", "issue": "7", "pages": "e1009183"}, "abstract": "Coronavirus disease 2019 (COVID-19) is an acute infection of the respiratory tract that emerged in December 2019 in Wuhan, China. It was quickly established that both the symptoms and the disease severity may vary from one case to another and several strains of SARS-CoV-2 have been identified. To gain a better understanding of the wide variety of SARS-CoV-2 strains and their associated symptoms, thousands of SARS-CoV-2 genomes have been sequenced in dozens of countries. In this article, we introduce COVIDomic, a multi-omics online platform designed to facilitate the analysis and interpretation of the large amount of health data collected from patients with COVID-19. The COVIDomic platform provides a comprehensive set of bioinformatic tools for the multi-modal metatranscriptomic data analysis of COVID-19 patients to determine the origin of the coronavirus strain and the expected severity of the disease. An integrative analytical workflow, which includes microbial pathogens community analysis, COVID-19 genetic epidemiology and patient stratification, allows to analyze the presence of the most common microbial organisms, their antibiotic resistance, the severity of the infection and the set of the most probable geographical locations from which the studied strain could have originated. The online platform integrates a user friendly interface which allows easy visualization of the results. We envision this tool will not only have immediate implications for management of the ongoing COVID-19 pandemic, but will also improve our readiness to respond to other infectious outbreaks.", "doi": "10.1371/journal.pcbi.1009183", "pmid": "34260589", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8312936"}, {"db": "pii", "key": "PCOMPBIOL-D-21-00029"}], "notes": [], "created": "2021-08-06T07:21:00.826Z", "modified": "2023-06-19T07:30:59.263Z"}, {"entity": "publication", "iuid": "b4b16c88742546d48699006bd1d5fc0b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b4b16c88742546d48699006bd1d5fc0b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b4b16c88742546d48699006bd1d5fc0b"}}, "title": "COVID-19: Symptoms in Dying Residents of Nursing Homes and in Those Admitted to Hospitals.", "authors": [{"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "Martinsson", "given": "Lisa", "initials": "L"}, {"family": "Bergstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Staffan", "initials": "S"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "J Palliat Med", "issn": "1557-7740", "volume": "24", "issue": "7", "pages": "1067-1071", "issn-l": null}, "abstract": "To compare symptom prevalence and relief in residents who died in nursing homes with residents who were acutely referred to hospitals. Objective: Data on symptoms during the last week of life from the Swedish Register of Palliative Care (SRPC). Design: Nursing homes (Setting and Subjects:n = 1903 deaths) and hospitals in Sweden (n = 202 nursing home residents who were admitted to hospital before death). Data were retrieved on August 24, 2020. Residents who died in hospitals had more breakthrough symptoms of breathlessness (60% vs. 31%, Results:p < 0.0001) and delirium (41% vs. 25%, p < 0.0001) than those who died in nursing homes. When symptoms were present, complete symptom relief was seen less often in hospitals compared with nursing homes (breathlessness, 28% vs. 47%, p < 0.001; delirium, 10% vs. 35%, p < 0.0001; respiratory secretions, 30% vs. 55%, p < 0.0001). Despite access to oxygen and pharmacologic/nonpharmacologic therapies in hospitals, symptom relief in dying nursing home residents acutely admitted to hospitals was lower compared with those who died in nursing homes, possibly because of differences in patient characteristics.Conclusion:", "doi": "10.1089/jpm.2020.0688", "pmid": "33667124", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-06T10:08:49.786Z", "modified": "2021-11-18T12:46:26.602Z"}, {"entity": "publication", "iuid": "861353a5c9474b8e9a227a18527a8b24", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/861353a5c9474b8e9a227a18527a8b24.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/861353a5c9474b8e9a227a18527a8b24"}}, "title": "An outbreak caused by the SARS-CoV-2 Delta variant (B.1.617.2) in a secondary care hospital in Finland, May 2021.", "authors": [{"family": "Hetem\u00e4ki", "given": "Iivo", "initials": "I"}, {"family": "K\u00e4\u00e4ri\u00e4inen", "given": "Sohvi", "initials": "S"}, {"family": "Alho", "given": "Pirjo", "initials": "P"}, {"family": "Mikkola", "given": "Janne", "initials": "J"}, {"family": "Savolainen-Kopra", "given": "Carita", "initials": "C"}, {"family": "Ikonen", "given": "Niina", "initials": "N"}, {"family": "Nohynek", "given": "Hanna", "initials": "H"}, {"family": "Lyytik\u00e4inen", "given": "Outi", "initials": "O"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "30", "issn-l": null}, "abstract": "An outbreak caused by the SARS-CoV-2 Delta variant (B.1.617.2) spread from one inpatient in a secondary care hospital to three primary care facilities, resulting in 58 infections including 18 deaths in patients and 45 infections in healthcare workers (HCW). Only one of the deceased cases was fully vaccinated. Transmission occurred despite the use of personal protective equipment by the HCW, as advised in national guidelines, and a high two-dose COVID-19 vaccination coverage among permanent staff members in the COVID-19 cohort ward.", "doi": "10.2807/1560-7917.ES.2021.26.30.2100636", "pmid": "34328076", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-04T17:04:15.593Z", "modified": "2021-08-04T17:04:15.606Z"}, {"entity": "publication", "iuid": "075dd5d3c80e4e08889468b3e65d1264", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/075dd5d3c80e4e08889468b3e65d1264.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/075dd5d3c80e4e08889468b3e65d1264"}}, "title": "Acute pulmonary hypertension and short-term outcomes in severe Covid-19 patients needing intensive care.", "authors": [{"family": "Norderfeldt", "given": "Joakim", "initials": "J"}, {"family": "Liliequist", "given": "Andreas", "initials": "A"}, {"family": "Frostell", "given": "Claes", "initials": "C", "orcid": "0000-0002-7199-1310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874beab519f143db8659a7936aa46142.json"}}, {"family": "Adding", "given": "Christofer", "initials": "C"}, {"family": "Agvald", "given": "Per", "initials": "P"}, {"family": "Eriksson", "given": "Maria", "initials": "M"}, {"family": "L\u00f6nnqvist", "given": "Per-Arne", "initials": "PA", "orcid": "0000-0002-8586-1429", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c49ad645c3064040b0b4f225529e9237.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": "65", "issue": "6", "pages": "761-769"}, "abstract": "Critically ill Covid-19 pneumonia patients are likely to develop the sequence of acute pulmonary hypertension, right ventricular (RV) strain, and eventually RV failure due to known pathophysiology (endothelial inflammation plus thrombo-embolism) that promotes increased pulmonary vascular resistance and pulmonary artery pressure. This study aimed to investigate the occurrence of acute pulmonary hypertension (aPH) as per established trans-thoracic echocardiography (TTE) criteria in Covid-19 patients receiving intensive care and to explore whether short-term outcomes are affected by the presence of aPH.\n\nMedical records were reviewed for patients treated in the intensive care units at a tertiary university hospital over a month. The presence of aPH on the TTE was noted, and plasma NTproBNP and troponin were measured as markers of cardiac failure and myocardial injury, respectively. Follow-up data were collected 21 d after the performance of TTE.\n\nIn total, 26 of 67 patients (39%) had an assessed systolic pulmonary artery pressure of > 35 mmHg (group aPH), meeting the TTE definition of aPH. NTproBNP levels (median [range]: 1430 [102-30 300] vs. 470 [45-29 600] ng L-1 ; P = .0007), troponin T levels (63 [22-352] vs. 15 [5-407] ng L-1 ; P = .0002), and the 21-d mortality rate (46% vs. 7%; P < .001) were substantially higher in patients with aPH compared to patients not meeting aPH criteria.\n\nTTE-defined acute pulmonary hypertension was frequently observed in severely ill Covid-19 patients. Furthermore, aPH was linked to biomarker-defined myocardial injury and cardiac failure, as well as an almost sevenfold increase in 21-d mortality.", "doi": "10.1111/aas.13819", "pmid": "33728633", "labels": {"Category: Health": null, "Type: Journal article": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC8250592"}], "notes": [], "created": "2021-03-22T11:31:19.318Z", "modified": "2021-11-18T13:18:45.397Z"}, {"entity": "publication", "iuid": "256bb4b8a56d4afca0d477c714ea20de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/256bb4b8a56d4afca0d477c714ea20de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/256bb4b8a56d4afca0d477c714ea20de"}}, "title": "A call for standardised age-disaggregated health data.", "authors": [{"family": "Diaz", "given": "Theresa", "initials": "T"}, {"family": "Strong", "given": "Kathleen L", "initials": "KL"}, {"family": "Cao", "given": "Bochen", "initials": "B"}, {"family": "Guthold", "given": "Regina", "initials": "R"}, {"family": "Moran", "given": "Allisyn C", "initials": "AC"}, {"family": "Moller", "given": "Ann-Beth", "initials": "AB"}, {"family": "Requejo", "given": "Jennifer", "initials": "J"}, {"family": "Sadana", "given": "Ritu", "initials": "R"}, {"family": "Thiyagarajan", "given": "Jotheeswaran Amuthavalli", "initials": "JA"}, {"family": "Adebayo", "given": "Emmanuel", "initials": "E"}, {"family": "Akwara", "given": "Elsie", "initials": "E"}, {"family": "Amouzou", "given": "Agbessi", "initials": "A"}, {"family": "Aponte Varon", "given": "John J", "initials": "JJ"}, {"family": "Azzopardi", "given": "Peter S", "initials": "PS"}, {"family": "Boschi-Pinto", "given": "Cynthia", "initials": "C"}, {"family": "Carvajal", "given": "Liliana", "initials": "L"}, {"family": "Chandra-Mouli", "given": "Venkatraman", "initials": "V"}, {"family": "Crofts", "given": "Sarah", "initials": "S"}, {"family": "Dastgiri", "given": "Saeed", "initials": "S"}, {"family": "Dery", "given": "Jeremiah S", "initials": "JS"}, {"family": "Elnakib", "given": "Shatha", "initials": "S"}, {"family": "Fagan", "given": "Laura", "initials": "L"}, {"family": "Jane Ferguson", "given": "B", "initials": "B"}, {"family": "Fitzner", "given": "Julia", "initials": "J"}, {"family": "Friedman", "given": "Howard S", "initials": "HS"}, {"family": "Hagell", "given": "Ann", "initials": "A"}, {"family": "Jongstra", "given": "Eduard", "initials": "E"}, {"family": "Kann", "given": "Laura", "initials": "L"}, {"family": "Chatterji", "given": "Somnath", "initials": "S"}, {"family": "English", "given": "Mike", "initials": "M"}, {"family": "Glaziou", "given": "Philippe", "initials": "P"}, {"family": "Hanson", "given": "Claudia", "initials": "C"}, {"family": "Hosseinpoor", "given": "Ahmad R", "initials": "AR"}, {"family": "Marsh", "given": "Andrew", "initials": "A"}, {"family": "Morgan", "given": "Alison P", "initials": "AP"}, {"family": "Munos", "given": "Melinda K", "initials": "MK"}, {"family": "Noor", "given": "Abdisalan", "initials": "A"}, {"family": "Pavlin", "given": "Boris I", "initials": "BI"}, {"family": "Pereira", "given": "Rich", "initials": "R"}, {"family": "Porth", "given": "Tyler A", "initials": "TA"}, {"family": "Schellenberg", "given": "Joanna", "initials": "J"}, {"family": "Siddique", "given": "Rizwana", "initials": "R"}, {"family": "You", "given": "Danzhen", "initials": "D"}, {"family": "Vaz", "given": "Lara M E", "initials": "LME"}, {"family": "Banerjee", "given": "Anshu", "initials": "A"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Lancet Healthy Longev", "issn": "2666-7568", "volume": "2", "issue": "7", "pages": "e436-e443", "issn-l": null}, "abstract": "The 2030 Sustainable Development Goals agenda calls for health data to be disaggregated by age. However, age groupings used to record and report health data vary greatly, hindering the harmonisation, comparability, and usefulness of these data, within and across countries. This variability has become especially evident during the COVID-19 pandemic, when there was an urgent need for rapid cross-country analyses of epidemiological patterns by age to direct public health action, but such analyses were limited by the lack of standard age categories. In this Personal View, we propose a recommended set of age groupings to address this issue. These groupings are informed by age-specific patterns of morbidity, mortality, and health risks, and by opportunities for prevention and disease intervention. We recommend age groupings of 5 years for all health data, except for those younger than 5 years, during which time there are rapid biological and physiological changes that justify a finer disaggregation. Although the focus of this Personal View is on the standardisation of the analysis and display of age groups, we also outline the challenges faced in collecting data on exact age, especially for health facilities and surveillance data. The proposed age disaggregation should facilitate targeted, age-specific policies and actions for health care and disease management.", "doi": "10.1016/S2666-7568(21)00115-X", "pmid": "34240065", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2666-7568(21)00115-X"}, {"db": "pmc", "key": "PMC8245325"}], "notes": [], "created": "2021-08-06T07:59:40.130Z", "modified": "2021-08-06T07:59:49.181Z"}, {"entity": "publication", "iuid": "cacc1bbd7796404bbf4f3a9b24e217fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cacc1bbd7796404bbf4f3a9b24e217fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cacc1bbd7796404bbf4f3a9b24e217fd"}}, "title": "Up State of the SARS-COV-2 Spike Homotrimer Favors an Increased Virulence for New Variants.", "authors": [{"family": "Giron", "given": "Carolina Corr\u00eaa", "initials": "CC"}, {"family": "Laaksonen", "given": "Aatto", "initials": "A"}, {"family": "Barroso da Silva", "given": "Fernando Lu\u00eds", "initials": "FL"}], "type": "journal article", "published": "2021-06-30", "journal": {"title": "Front Med Technol", "issn": "2673-3129", "issn-l": null, "volume": "3", "issue": null, "pages": "694347"}, "abstract": "The COVID-19 pandemic has spread worldwide. However, as soon as the first vaccines-the only scientifically verified and efficient therapeutic option thus far-were released, mutations combined into variants of SARS-CoV-2 that are more transmissible and virulent emerged, raising doubts about their efficiency. This study aims to explain possible molecular mechanisms responsible for the increased transmissibility and the increased rate of hospitalizations related to the new variants. A combination of theoretical methods was employed. Constant-pH Monte Carlo simulations were carried out to quantify the stability of several spike trimeric structures at different conformational states and the free energy of interactions between the receptor-binding domain (RBD) and angiotensin-converting enzyme II (ACE2) for the most worrying variants. Electrostatic epitopes were mapped using the PROCEEDpKa method. These analyses showed that the increased virulence is more likely to be due to the improved stability to the S trimer in the opened state, in which the virus can interact with the cellular receptor, ACE2, rather than due to alterations in the complexation RBD-ACE2, since the difference observed in the free energy values was small (although more attractive in general). Conversely, the South African/Beta variant (B.1.351), compared with the SARS-CoV-2 wild type (wt), is much more stable in the opened state with one or two RBDs in the up position than in the closed state with three RBDs in the down position favoring the infection. Such results contribute to understanding the natural history of disease and indicate possible strategies for developing new therapeutic molecules and adjusting the vaccine doses for higher B-cell antibody production.", "doi": "10.3389/fmedt.2021.694347", "pmid": "35047936", "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8757851"}], "notes": [], "created": "2022-01-27T07:01:54.014Z", "modified": "2022-01-27T07:03:25.405Z"}, {"entity": "publication", "iuid": "6f864b2f4ae5498b87b581187353d13f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f864b2f4ae5498b87b581187353d13f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f864b2f4ae5498b87b581187353d13f"}}, "title": "The concerns of oncology professionals during the COVID-19 pandemic: results from the ESMO Resilience Task Force survey II.", "authors": [{"family": "Lim", "given": "K H J", "initials": "KHJ"}, {"family": "Murali", "given": "K", "initials": "K"}, {"family": "Kamposioras", "given": "K", "initials": "K"}, {"family": "Punie", "given": "K", "initials": "K"}, {"family": "Oing", "given": "C", "initials": "C"}, {"family": "O'Connor", "given": "M", "initials": "M"}, {"family": "Thorne", "given": "E", "initials": "E"}, {"family": "Amaral", "given": "T", "initials": "T"}, {"family": "Garrido", "given": "P", "initials": "P"}, {"family": "Lambertini", "given": "M", "initials": "M"}, {"family": "Devnani", "given": "B", "initials": "B"}, {"family": "Westphalen", "given": "C B", "initials": "CB"}, {"family": "Morgan", "given": "G", "initials": "G"}, {"family": "Haanen", "given": "J B A G", "initials": "JBAG"}, {"family": "Hardy", "given": "C", "initials": "C"}, {"family": "Banerjee", "given": "S", "initials": "S"}], "type": "journal article", "published": "2021-06-30", "journal": {"title": "ESMO Open", "issn": "2059-7029", "volume": "6", "issue": "4", "pages": "100199", "issn-l": null}, "abstract": "The COVID-19 pandemic has resulted in significant changes to professional and personal lives of oncology professionals globally. The European Society for Medical Oncology (ESMO) Resilience Task Force collaboration aimed to provide contemporaneous reports on the impact of COVID-19 on the lived experiences and well-being in oncology.\n\nThis online anonymous survey (July-August 2020) is the second of a series of global surveys launched during the course of the pandemic. Longitudinal key outcome measures including well-being/distress (expanded Well-being Index-9 items), burnout (1 item from expanded Well-being Index), and job performance since COVID-19 were tracked.\n\nA total of 942 participants from 99 countries were included for final analysis: 58% (n = 544) from Europe, 52% (n = 485) female, 43% (n = 409) \u226440 years old, and 36% (n = 343) of non-white ethnicity. In July/August 2020, 60% (n = 525) continued to report a change in professional duties compared with the pre-COVID-19 era. The proportion of participants at risk of poor well-being (33%, n = 310) and who reported feeling burnout (49%, n = 460) had increased significantly compared with April/May 2020 (25% and 38%, respectively; P < 0.001), despite improved job performance since COVID-19 (34% versus 51%; P < 0.001). Of those who had been tested for COVID-19, 8% (n = 39/484) tested positive; 18% (n = 7/39) felt they had not been given adequate time to recover before return to work. Since the pandemic, 39% (n = 353/908) had expressed concerns that COVID-19 would have a negative impact on their career development or training and 40% (n = 366/917) felt that their job security had been compromised. More than two-thirds (n = 608/879) revealed that COVID-19 has changed their outlook on their work-personal life balance.\n\nThe COVID-19 pandemic continues to impact the well-being of oncology professionals globally, with significantly more in distress and feeling burnout compared with the first wave. Collective efforts from both national and international communities addressing support and coping strategies will be crucial as we recover from the COVID-19 crisis. In particular, an action plan should also be devised to tackle concerns raised regarding the negative impact of COVID-19 on career development, training, and job security.", "doi": "10.1016/j.esmoop.2021.100199", "pmid": "34217129", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2059-7029(21)00160-5"}], "notes": [], "created": "2021-07-05T15:03:06.220Z", "modified": "2021-07-05T15:03:54.367Z"}, {"entity": "publication", "iuid": "9be4d53064af40d2b097b15b815355dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9be4d53064af40d2b097b15b815355dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9be4d53064af40d2b097b15b815355dd"}}, "title": "Summary of European guidelines on infection control and prevention during COVID-19 pandemic.", "authors": [{"family": "Becker", "given": "Kathrin", "initials": "K", "orcid": "0000-0003-1936-4683", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cfa273f3515e470c87ad24540f6398f0.json"}}, {"family": "Gurzawska-Comis", "given": "Katarzyna", "initials": "K", "orcid": "0000-0002-3424-5968", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2b36d90d1804c67aa844537ce625fe7.json"}}, {"family": "Brunello", "given": "Giulia", "initials": "G", "orcid": "0000-0003-1436-0085", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c41e6e7b6a6d4070ba5e61aec8e085ad.json"}}, {"family": "Klinge", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0003-2100-2446", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b0a71c3b5b93430c817278f62204b5db.json"}}], "type": "journal article", "published": "2021-06-30", "journal": {"title": "Clin Oral Implants Res", "issn": "1600-0501", "issn-l": null}, "abstract": "The current COVID-19 pandemic highlighted the need for a review of guidelines on infection control and prevention to ensure safe delivery of dental care. However, it is not clear to what extent the rapidly published European guidelines reflect the current evidence and thus provide homogeneous recommendations.\n\nGuidelines from all European Union countries, Scotland, Switzerland and United Kingdom were retrieved. Information on triage, mouth rinse, personal protective equipment (PPE) for aerosol free/ generating procedures (non-AGP/AGP) and treatment of potentially infectious patients were summarised, and compared with recommendations from international organizations (WHO, ECDC, CDC).\n\nAll included countries (30/30) published COVID-19 guidelines in 2020. All countries recommended triage and to postpone non-urgent treatment of potentially infectious patients. Hydrogen peroxide (1-1.5%) was the most frequently recommended antiseptic mouth rinse to reduce viral load (24/30). PPE for non-AGP treatments included mainly surgical masks (21/30) or FFP2/FFP3/N95 masks (16/30), whereas FFP2/FFP3 masks (25/30) and face shields (24/30) were recommended for AGP by the vast majority of guidelines. For high-risk/COVID positive patients, most countries recommended maximum protection, and treatment in specialised dental clinics (22/30).\n\nThere was general agreement among recommendations for triage, mouth rinse, and PPE during AGP and treatment of potentially infectious patients. In contrast, recommendations on PPE for non-AGP treatment varied considerably among the European countries possibly due to limited scientific evidence regarding transmission risk during non-AGP treatments.", "doi": "10.1111/clr.13784", "pmid": "34196047", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-07-05T14:31:00.569Z", "modified": "2021-07-05T14:31:00.690Z"}, {"entity": "publication", "iuid": "d37e5e75fe864447a97b9b63be6cab54", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d37e5e75fe864447a97b9b63be6cab54.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d37e5e75fe864447a97b9b63be6cab54"}}, "title": "ReCOV: recovery and rehabilitation during and after COVID-19 - a study protocol of a longitudinal observational study on patients, next of kin and health care staff.", "authors": [{"family": "Rydwik", "given": "E", "initials": "E", "orcid": "0000-0003-0550-1675", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03e46fbd5a7547ecb1f98245d30f3586.json"}}, {"family": "Anmyr", "given": "L", "initials": "L"}, {"family": "Regardt", "given": "M", "initials": "M"}, {"family": "McAllister", "given": "A", "initials": "A"}, {"family": "Zarenoe", "given": "R", "initials": "R"}, {"family": "\u00c5kerman", "given": "E", "initials": "E"}, {"family": "Orrevall", "given": "Y", "initials": "Y"}, {"family": "Bragesj\u00f6", "given": "M", "initials": "M"}, {"family": "Dahl", "given": "O", "initials": "O"}, {"family": "Kemani", "given": "M K", "initials": "MK"}, {"family": "Nordstrand", "given": "L", "initials": "L"}, {"family": "Ekman", "given": "U", "initials": "U"}, {"family": "Holmstr\u00f6m", "given": "L", "initials": "L"}, {"family": "Nygren-Bonnier", "given": "M", "initials": "M"}], "type": "journal article", "published": "2021-06-30", "journal": {"title": "BMC Sports Sci Med Rehabil", "issn": "2052-1847", "issn-l": null, "volume": "13", "issue": "1", "pages": "70"}, "abstract": "The knowledge of the long-term consequences of covid-19 is limited. In patients, symptoms such as fatigue, decreased physical, psychological, and cognitive function, and nutritional problems have been reported. How the disease has affected next of kin, as well as staff involved in the care of patients with covid-19, is also largely unknown. The overall aim of this study is therefore three-fold: (1) to describe and evaluate predictors of patient recovery, the type of rehabilitation received and patients' experiences of specialized rehabilitation following COVID-19 infection; (2) to study how next of kin experienced the hospital care of their relative and their experiences of the psychosocial support they received as well as their psychological wellbeing; (3) to describe experiences of caring for patients with COVID-19 and evaluate psychological wellbeing, coping mechanisms and predictors for development of psychological distress over time in health care staff.\n\nThis observational longitudinal study consists of three cohorts; patients, next of kin, and health care staff. The assessments for the patients consist of physical tests (lung function, muscle strength, physical capacity) and questionnaires (communication and swallowing, nutritional status, hearing, activities of daily living, physical activity, fatigue, cognition) longitudinally at 3, 6 and 12 months. Patient records auditing (care, rehabilitation) will be done retrospectively at 12 months. Patients (3, 6 and 12 months), next of kin (6 months) and health care staff (baseline, 3, 6, 9 and 12 months) will receive questionnaires regarding, health-related quality of life, depression, anxiety, sleeping disorders, and post-traumatic stress. Staff will also answer questionnaires about burnout and coping strategies. Interviews will be conducted in all three cohorts.\n\nThis study will be able to answer different research questions from a quantitative and qualitative perspective, by describing and evaluating long-term consequences and their associations with recovery, as well as exploring patients', next of kins' and staffs' views and experiences of the disease and its consequences. This will form a base for a deeper and better understanding of the consequences of the disease from different perspectives as well as helping the society to better prepare for a future pandemic.", "doi": "10.1186/s13102-021-00299-9", "pmid": "34193260", "labels": {"Category: Public Health": null, "Type: Journal article": null, "Category: Rehabilitation": null}, "xrefs": [{"db": "pmc", "key": "PMC8243048"}, {"db": "pii", "key": "10.1186/s13102-021-00299-9"}], "notes": [], "created": "2021-07-05T14:28:53.739Z", "modified": "2023-06-19T15:22:19.071Z"}, {"entity": "publication", "iuid": "67ce74a43c114f79ad88ccc156f49658", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/67ce74a43c114f79ad88ccc156f49658.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/67ce74a43c114f79ad88ccc156f49658"}}, "title": "Investigation of Four Clusters of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Rwanda, 2020.", "authors": [{"family": "Nsekuye", "given": "Olivier", "initials": "O"}, {"family": "Rwagasore", "given": "Edson", "initials": "E"}, {"family": "Muhimpundu", "given": "Marie Aime", "initials": "MA"}, {"family": "El-Khatib", "given": "Ziad", "initials": "Z", "orcid": "0000-0003-0756-7280", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31747e0476314de9bf53d8c8f3d1d147.json"}}, {"family": "Ntabanganyimana", "given": "Daniel", "initials": "D", "orcid": "0000-0003-2183-7873", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c49ec8a0b5e4c1e97744c1540826453.json"}}, {"family": "Kamayirese", "given": "Eric No\u00ebl", "initials": "EN"}, {"family": "Ruyange", "given": "Laurent", "initials": "L"}, {"family": "Umutoni", "given": "Angela", "initials": "A"}, {"family": "Adeline", "given": "Adeline Kabeja", "initials": "AK"}, {"family": "Ntaganira", "given": "Joseph", "initials": "J"}, {"family": "Nsazimana", "given": "Sabin", "initials": "S"}, {"family": "Omolo", "given": "Jared", "initials": "J"}], "type": "journal article", "published": "2021-06-30", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "13", "pages": "7018"}, "abstract": "We reported the findings of the first Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) four clusters identified in Rwanda. Case-investigations included contact elicitation, testing, and isolation/quarantine of confirmed cases. Socio-demographic and clinical data on cases and contacts were collected. A confirmed case was a person with laboratory confirmation of SARS-CoV-2 infection (PCR) while a contact was any person who had contact with a SARS-CoV-2 confirmed case within 72 h prior, to 14 days after symptom onset; or 14 days before collection of the laboratory-positive sample for asymptomatic cases. High risk contacts were those who had come into unprotected face-to-face contact or had been in a closed environment with a SARS-CoV-2 case for >15 min. Forty cases were reported from four clusters by 22 April 2020, accounting for 61% of locally transmitted cases within six weeks. Clusters A, B, C and D were associated with two nightclubs, one house party, and different families or households living in the same compound (multi-family dwelling). Thirty-six of the 1035 contacts tested were positive (secondary attack rate: 3.5%). Positivity rates were highest among the high-risk contacts compared to low-risk contacts (10% vs. 2.2%). Index cases in three of the clusters were imported through international travelling. Fifteen of the 40 cases (38%) were asymptomatic while 13/25 (52%) and 8/25 (32%) of symptomatic cases had a cough and fever respectively. Gatherings in closed spaces were the main early drivers of transmission. Systematic case-investigations contact tracing and testing likely contributed to the early containment of SARS-CoV-2 in Rwanda.", "doi": "10.3390/ijerph18137018", "pmid": "34209123", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8297211"}, {"db": "pii", "key": "ijerph18137018"}], "notes": [], "created": "2021-07-05T14:56:56.299Z", "modified": "2023-06-19T15:17:29.655Z"}, {"entity": "publication", "iuid": "ef958c3e559b4e04ba017e6252046903", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef958c3e559b4e04ba017e6252046903.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef958c3e559b4e04ba017e6252046903"}}, "title": "Dental care during COVID-19 pandemic: follow-up survey of experts' opinion.", "authors": [{"family": "Brunello", "given": "Giulia", "initials": "G", "orcid": "0000-0003-1436-0085", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c41e6e7b6a6d4070ba5e61aec8e085ad.json"}}, {"family": "Gurzawska-Comis", "given": "Katarzyna", "initials": "K"}, {"family": "Becker", "given": "Kathrin", "initials": "K", "orcid": "0000-0003-1936-4683", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cfa273f3515e470c87ad24540f6398f0.json"}}, {"family": "Becker", "given": "J\u00fcrgen", "initials": "J"}, {"family": "Sivolella", "given": "Stefano", "initials": "S", "orcid": "0000-0003-1916-1640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9d22e893e164fb2958aeff923b6fad5.json"}}, {"family": "Schwarz", "given": "Frank", "initials": "F", "orcid": "0000-0001-5515-227X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5c1fcc3c85944960a9b564494441473d.json"}}, {"family": "Klinge", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2021-06-30", "journal": {"title": "Clin Oral Implants Res", "issn": "1600-0501", "issn-l": null}, "abstract": "The purpose of the present survey is to give an update of European experts' opinion on infection control and prevention in dentistry during second wave of pandemic. The secondary aim was to analyse how experts' opinion changed in the light of the new scientific evidence since the first wave.\n\nAn anonymous online 14-item questionnaire was sent to a total of 27 leading academic experts in Oral (and Maxillofacial) Surgery from different European countries, who had completed a previous survey in April-May 2020. The questionnaire covered the topics of dental setting safety, personal protective equipment (PPE), and patient-related measures to minimise transmission risk. Data collection took place in November-February 2020/21.\n\n26 experts participated in the follow-up survey. The overall transmission risk in dental settings was scored significantly lower compared to the initial survey (P<0.05), though the risk associated with aerosol generating procedures (AGP) was still considered to be high. Maximum PPE was less frequently recommended for non-AGP (P<0.05), whereas the majority of experts still recommended FFP2/FFP3 masks (80.8%), face shields or goggles (88.5%), gowns (61.5%), and caps (57.7%) for AGP. Most of the experts also found mouth rinse relevant (73.1%) and reported to be using it prior to treatment (76.9%). No uniform opinion was found regarding the relevance of COVID-19 testing of staff and patients.\n\nWith the continuation of dental care provision, transmission risk has been scored lower compared to the first wave of pandemic. However, high risk is still assumed for AGP, and maximum PPE remained advised for the respective treatments.", "doi": "10.1111/clr.13783", "pmid": "34196051", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-07-05T14:31:22.874Z", "modified": "2021-07-05T14:31:22.956Z"}, {"entity": "publication", "iuid": "32a80056c0f2441cbd9e3bc51494ca52", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/32a80056c0f2441cbd9e3bc51494ca52.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/32a80056c0f2441cbd9e3bc51494ca52"}}, "title": "Civic Duty: A Booster for Resilience?", "authors": [{"family": "Grimm", "given": "Pauline Yongeun", "initials": "PY"}, {"family": "Saulnier", "given": "Dell D", "initials": "DD"}], "type": "editorial", "published": "2021-06-30", "journal": {"title": "Int J Public Health", "issn": "1661-8564", "volume": "66", "pages": "1604064", "issn-l": null}, "abstract": null, "doi": "10.3389/ijph.2021.1604064", "pmid": "34335149", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "1604064"}, {"db": "pmc", "key": "PMC8284586"}], "notes": [], "created": "2021-08-04T10:13:00.336Z", "modified": "2021-08-04T10:13:00.358Z"}, {"entity": "publication", "iuid": "cde11c2a5b9d4d04b30c791570e1a5f3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cde11c2a5b9d4d04b30c791570e1a5f3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cde11c2a5b9d4d04b30c791570e1a5f3"}}, "title": "Widespread Parenchymal Abnormalities and Pulmonary Embolism on Contrast-Enhanced CT Predict Disease Severity and Mortality in Hospitalized COVID-19 Patients.", "authors": [{"family": "Jalde", "given": "Francesca Campoccia", "initials": "FC"}, {"family": "Beckman", "given": "Mats O", "initials": "MO"}, {"family": "Svensson", "given": "Ann Mari", "initials": "AM"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "Sk\u00f6ld", "given": "Magnus", "initials": "M"}, {"family": "Strand", "given": "Fredrik", "initials": "F"}, {"family": "Nyren", "given": "Sven", "initials": "S"}, {"family": "Kistner", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-06-29", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "8", "pages": "666723", "issn-l": null}, "abstract": "Purpose: Severe COVID-19 is associated with inflammation, thromboembolic disease, and high mortality. We studied factors associated with fatal outcomes in consecutive COVID-19 patients examined by computed tomography pulmonary angiogram (CTPA). Methods: This retrospective, single-center cohort analysis included 130 PCR-positive patients hospitalized for COVID-19 [35 women and 95 men, median age 57 years (interquartile range 51-64)] with suspected pulmonary embolism based on clinical suspicion. The presence and extent of embolism and parenchymal abnormalities on CTPA were recorded. The severity of pulmonary parenchymal involvement was stratified by two experienced radiologists into two groups: lesions affecting \u226450% or >50% of the parenchyma. Patient characteristics, radiological aspects, laboratory parameters, and 60-day mortality data were collected. Results: Pulmonary embolism was present in 26% of the patients. Most emboli were small and peripheral. Patients with widespread parenchymal abnormalities, with or without pulmonary embolism, had increased main pulmonary artery diameter (p < 0.05) and higher C-reactive protein (p < 0.01), D-dimer (p < 0.01), and troponin T (p < 0.001) and lower hemoglobin (p < 0.001). A wider main pulmonary artery diameter correlated positively with C-reactive protein (r = 0.28, p = 0.001, and n = 130) and procalcitonin. In a multivariant analysis, D-dimer >7.2 mg/L [odds ratio (\u00b195% confidence interval) 4.1 (1.4-12.0)] and ICU stay were significantly associated with embolism (p < 0.001). The highest 60-day mortality was found in patients with widespread parenchymal abnormalities combined with pulmonary embolism (36%), followed by patients with widespread parenchymal abnormalities without pulmonary embolism (26%). In multivariate analysis, high troponin T, D-dimer, and plasma creatinine and widespread parenchymal abnormalities on CT were associated with 60-day mortality. Conclusions: Pulmonary embolism combined with widespread parenchymal abnormalities contributed to mortality risk in COVID-19. Elevated C-reactive protein, D-dimer, troponin-T, P-creatinine, and enlarged pulmonary artery were associated with a worse outcome and may mirror a more severe systemic disease. A liberal approach to radiological investigation should be recommended at clinical deterioration, when the situation allows it. Computed tomography imaging, even without intravenous contrast to assess the severity of pulmonary infiltrates, are of value to predict outcome in COVID-19. Better radiological techniques with higher resolution could potentially improve the detection of microthromboses. This could influence anticoagulant treatment strategies, preventing clinical detoriation.", "doi": "10.3389/fmed.2021.666723", "pmid": "34268322", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8275973"}], "notes": [], "created": "2021-08-06T07:16:54.586Z", "modified": "2021-08-06T07:16:54.598Z"}, {"entity": "publication", "iuid": "578ea654c3144268b705f02fc41b589b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/578ea654c3144268b705f02fc41b589b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/578ea654c3144268b705f02fc41b589b"}}, "title": "The impact of the coronavirus (COVID-19) pandemic on individuals with gastrointestinal disorders: A protocol of an international collaborative study.", "authors": [{"family": "Ferreira", "given": "Nuno", "initials": "N"}, {"family": "Mikocka-Walus", "given": "Antonina", "initials": "A"}, {"family": "van Tilburg", "given": "Miranda A L", "initials": "MAL"}, {"family": "Graff", "given": "Lesley A", "initials": "LA"}, {"family": "Apputhurai", "given": "Pragalathan", "initials": "P"}, {"family": "Acosta", "given": "Manuel Barreiro-de", "initials": "MB"}, {"family": "Evertsz", "given": "Floor Bennebroek", "initials": "FB"}, {"family": "Burisch", "given": "Johan", "initials": "J"}, {"family": "Lo", "given": "Bobby", "initials": "B"}, {"family": "Petrik", "given": "Megan", "initials": "M"}, {"family": "Trindade", "given": "In\u00eas A", "initials": "IA"}, {"family": "Jedel", "given": "Sharon", "initials": "S"}, {"family": "Moser", "given": "Gabriele", "initials": "G"}, {"family": "Mokrowiecka", "given": "Anna", "initials": "A"}, {"family": "Bernstein", "given": "Charles N", "initials": "CN"}, {"family": "Dumitrascu", "given": "Dan", "initials": "D"}, {"family": "Ford", "given": "Alexander C", "initials": "AC"}, {"family": "Stengel", "given": "Andreas", "initials": "A"}, {"family": "Gearry", "given": "Richard", "initials": "R"}, {"family": "Knowles", "given": "Simon R", "initials": "SR"}], "type": "journal article", "published": "2021-06-29", "journal": {"title": "J Psychosom Res", "issn": "1879-1360", "volume": "148", "pages": "110561", "issn-l": null}, "abstract": "The COVID-19 pandemic has had a significant impact on mental health across the globe. People living with a chronic gastrointestinal (GI) disorder might be particularly at risk of mental health complications given higher rates of comorbid anxiety and depression compared to the healthy population. As GI disorders affect up to 40% of the population worldwide, this international collaborative study seeks to evaluate the extent of the impact of the COVID-19 pandemic on GI symptoms specifically and more generally on the well-being of those living with chronic GI conditions.\n\nA longitudinal survey with three time points (baseline, 6-month, and 12-month) will be conducted online. Adult participants with GI disorders from multiple countries will be recruited via patient associations, social media advertising, utilizing snowball sampling. Participants will be invited to complete a battery of questionnaires including demographic and health parameters, and measures of gastrointestinal symptoms, fear of COVID-19, perceived impact of COVID-19, illness perceptions, coping, depression, anxiety, stress, catastrophizing, and quality of life, using validated measures where available. Statistical analyses will include univariate descriptive models, multivariate models utilizing regression, mediation, and moderation, and latent growth models.\n\nThis project may present novel information to the field of psychogastroenterology and may provide crucial information regarding the areas of impact for individuals with GI disorders during and following the pandemic. Further, this information can guide healthcare providers and patient associations on how to target support related to the pandemic mental health sequelae for these patients.", "doi": "10.1016/j.jpsychores.2021.110561", "pmid": "34217956", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0022-3999(21)00206-3"}], "notes": [], "created": "2021-07-05T15:04:38.704Z", "modified": "2021-07-05T15:06:09.736Z"}, {"entity": "publication", "iuid": "a7060bc88a5641bcaafcfe88f603e514", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7060bc88a5641bcaafcfe88f603e514.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7060bc88a5641bcaafcfe88f603e514"}}, "title": "Seeing the value of experiential knowledge through COVID-19.", "authors": [{"family": "Atkinson", "given": "Sarah", "initials": "S", "orcid": "0000-0002-7186-0644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c24c1190d314847aec131249e583e59.json"}}, {"family": "Bradby", "given": "Hannah", "initials": "H", "orcid": "0000-0002-0664-1170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6650bd723f06404cb9f068d9bda13541.json"}}, {"family": "Gadebusch Bondio", "given": "Mariacarla", "initials": "M", "orcid": "0000-0002-5888-3059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53081b0715ff45b38f498a2fc8d3c09b.json"}}, {"family": "Hallberg", "given": "Anna", "initials": "A"}, {"family": "Macnaugthon", "given": "Jane", "initials": "J", "orcid": "0000-0002-7289-4037", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30fe568b9ecf480db633a8c576dad98d.json"}}, {"family": "S\u00f6derfeldt", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-6650-9710", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/193918c12f45489cb6cd8c949130e537.json"}}], "type": "journal article", "published": "2021-06-29", "journal": {"title": "Hist Philos Life Sci", "issn": "1742-6316", "volume": "43", "issue": "3", "pages": "85", "issn-l": null}, "abstract": "Seeing the entwinement of social and epistemic challenges through COVID, we discuss the perils of simplistic appeals to 'follow the science'. A hardened scientism risks excarbating social conflict and fueling conspiracy beliefs. Instead, we see an opportunity to devise more inclusive medical knowledge practices through endorsing experiential knowledge alongside traditional evidence types.", "doi": "10.1007/s40656-021-00438-y", "pmid": "34185187", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40656-021-00438-y"}], "notes": [], "created": "2021-06-30T04:58:23.052Z", "modified": "2021-06-30T04:58:23.181Z"}, {"entity": "publication", "iuid": "8c8581cfbe8541fc86599ac454263ffa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c8581cfbe8541fc86599ac454263ffa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c8581cfbe8541fc86599ac454263ffa"}}, "title": "Prevalence and incidence of anti-SARS-CoV-2 antibodies among healthcare workers in Belgian hospitals before vaccination: a prospective cohort study.", "authors": [{"family": "Mortgat", "given": "Laure", "initials": "L", "orcid": "0000-0002-8298-8547", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c830ab924e74a4285176040566ba96c.json"}}, {"family": "Verdonck", "given": "Kristien", "initials": "K", "orcid": "0000-0003-1153-4078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44033acf25e24dfb945b0c6300d2be4f.json"}}, {"family": "Hutse", "given": "Veronik", "initials": "V"}, {"family": "Thomas", "given": "Isabelle", "initials": "I"}, {"family": "Barbezange", "given": "Cyril", "initials": "C"}, {"family": "Heyndrickx", "given": "Leo", "initials": "L"}, {"family": "Fischer", "given": "Natalie", "initials": "N"}, {"family": "Vuylsteke", "given": "Bea", "initials": "B"}, {"family": "Kabouche", "given": "Ines", "initials": "I"}, {"family": "Ari\u00ebn", "given": "Kevin K", "initials": "KK"}, {"family": "Desombere", "given": "Isabelle", "initials": "I"}, {"family": "Duysburgh", "given": "Els", "initials": "E"}], "type": "journal article", "published": "2021-06-29", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "6", "pages": "e050824", "issn-l": "2044-6055"}, "abstract": "To describe prevalence and incidence of anti-SARS-CoV-2 antibodies among Belgian hospital healthcare workers (HCW) in April-December 2020.\n\nProspective cohort study. Follow-up was originally planned until September and later extended.\n\nMulticentre study, 17 hospitals.\n\n50 HCW were randomly selected per hospital. HCW employed beyond the end of the study and whose profession involved contact with patients were eligible. 850 HCW entered the study in April-May 2020, 673 HCW (79%) attended the September visit and 308 (36%) the December visit.\n\nA semiquantitative ELISA was used to detect IgG against SARS-CoV-2 in serum (Euroimmun) at 10 time points. In seropositive samples, neutralising antibodies were measured using a virus neutralisation test. Real-time reverse transcription PCR (RT-qPCR) was performed to detect SARS-CoV-2 on nasopharyngeal swabs. Participant characteristics and the presence of symptoms were collected via an online questionnaire.\n\nAmong all participants, 80% were women, 60% nurses and 21% physicians. Median age was 40 years. The seroprevalence remained relatively stable from April (7.7% (95% CI: 4.8% to 12.1%) to September (8.2% (95% CI: 5.7% to 11.6%)) and increased thereafter, reaching 19.7% (95% CI: 12.0% to 30.6%) in December 2020. 76 of 778 initially seronegative participants seroconverted during the follow-up (incidence: 205/1000 person-years). Among all seropositive individuals, 118/148 (80%) had a positive neutralisation test, 83/147 (56%) presented or reported a positive RT-qPCR, and 130/147 (88%) reported COVID-19-compatible symptoms at least once. However, only 46/73 (63%) of the seroconverters presented COVID-19-compatible symptoms in the month prior to seroconversion.\n\nThe seroprevalence among hospital HCW was slightly higher than that of the general Belgian population but followed a similar evolution, suggesting that infection prevention and control measures were effective and should be strictly maintained. After two SARS-CoV-2 waves, 80% of HCW remained seronegative, justifying their prioritisation in the vaccination strategy.\n\nNCT04373889.", "doi": "10.1136/bmjopen-2021-050824", "pmid": "34187832", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-050824"}, {"db": "pmc", "key": "PMC8245288"}, {"db": "ClinicalTrials.gov", "key": "NCT04373889"}], "notes": [], "created": "2021-07-05T14:23:22.273Z", "modified": "2021-07-05T14:23:22.338Z"}, {"entity": "publication", "iuid": "9eb01593d4c547d7823b006e981ce6fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9eb01593d4c547d7823b006e981ce6fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9eb01593d4c547d7823b006e981ce6fc"}}, "title": "Combined Metabolic Activators Accelerates Recovery in Mild\u2010to\u2010Moderate COVID\u201019", "authors": [{"family": "Altay", "given": "Ozlem", "initials": "O"}, {"family": "Arif", "given": "Muhammad", "initials": "M"}, {"family": "Li", "given": "Xiangyu", "initials": "X"}, {"family": "Yang", "given": "Hong", "initials": "H"}, {"family": "Ayd\u0131n", "given": "Mehtap", "initials": "M"}, {"family": "Alkurt", "given": "Gizem", "initials": "G"}, {"family": "Kim", "given": "Woonghee", "initials": "W"}, {"family": "Akyol", "given": "Dogukan", "initials": "D"}, {"family": "Zhang", "given": "Cheng", "initials": "C"}, {"family": "Dinler\u2010Doganay", "given": "Gizem", "initials": "G"}, {"family": "Turkez", "given": "Hasan", "initials": "H"}, {"family": "Shoaie", "given": "Saeed", "initials": "S"}, {"family": "Nielsen", "given": "Jens", "initials": "J"}, {"family": "Bor\u00e9n", "given": "Jan", "initials": "J"}, {"family": "Olmuscelik", "given": "Oktay", "initials": "O"}, {"family": "Doganay", "given": "Levent", "initials": "L"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A"}], "type": "journal-article", "published": "2021-06-28", "journal": {"title": "Adv. Sci.", "issn": "2198-3844", "issn-l": null, "volume": null, "issue": null, "pages": "2101222"}, "abstract": null, "doi": "10.1002/advs.202101222", "pmid": null, "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.1002/advs.202101222", "description": "Raw, patient-level characteristics and data"}], "notes": [], "created": "2021-06-28T18:03:41.425Z", "modified": "2021-07-06T09:30:30.964Z"}, {"entity": "publication", "iuid": "886c0b7aa006483ebf152b73ed4aab93", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/886c0b7aa006483ebf152b73ed4aab93.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/886c0b7aa006483ebf152b73ed4aab93"}}, "title": "Case Report: Systemic Sclerosis After Covid-19 Infection.", "authors": [{"family": "Fineschi", "given": "Serena", "initials": "S"}], "type": "case reports", "published": "2021-06-28", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "12", "pages": "686699", "issn-l": "1664-3224"}, "abstract": "The coronavirus disease (COVID-19) is a respiratory tract infection caused by the new virus SARS-CoV-2. The acute phase of the infection may in certain individuals be followed by another longer phase of disease (long COVID) of unknown etiology probably associated in certain cases with autoimmune activation. It has been shown that COVID-19 can trigger autoantibody production and in genetically predisposed patients may cause the onset or exacerbation of autoimmune diseases. We are reporting a case of mild COVID-19 infection complicated by autoantibody production and cutaneous and gastrointestinal symptoms and subsequently diagnosed with systemic sclerosis (SSc). A 47-year-old man with no history of any autoimmune diseases and in good health became sick together with his family on the 12th of November with mild symptoms: tiredness, fever, cough, and sore throat. Oropharyngeal swab for SARS-CoV-2 tested positive. He was isolated at home and did not require hospitalization. Three weeks later he presented with clinical manifestation compatible with suspicion of SSc. He briefly presented with skin rush, periorbital edema and conjunctivitis, vomiting, dysphagia, burning sensation in the skin, above all in the fingertips and around the mouth, puffy fingers, Raynaud's phenomenon, pain at the fingertip of the middle finger where a depressed area was noticed without a clear ulceration. ANA showed a strongly positive nucleolar pattern. Anti-PM/Scl 75 and PM/Scl 100 resulted positive. High-resolution computed tomography (HCRT) showed early stage of interstitial lung disease (ILD). The patient was diagnosed with SSc based on the persistence of autoantibodies and the clinical and radiological pictures according to the ACR/EULAR classification (scores: puffy finger, 2; ILD, 2; Raynaud's phenomenon, 3; SSc related antibodies, 3; total 10). There are several cases described in the medical literature of possible new onset of SLE after COVID-19 infection. This is the first case that describes a possible new onset of SSc. Conclusion: SARS-CoV-2 may trigger systemic sclerosis.", "doi": "10.3389/fimmu.2021.686699", "pmid": "34262566", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8273695"}], "notes": [], "created": "2021-08-06T07:17:58.171Z", "modified": "2021-08-06T07:18:53.884Z"}, {"entity": "publication", "iuid": "fb6a3ca888ca4cedbbc1e13a3fed36be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb6a3ca888ca4cedbbc1e13a3fed36be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb6a3ca888ca4cedbbc1e13a3fed36be"}}, "title": "A review and agenda for integrated disease models including social and behavioural factors.", "authors": [{"family": "Bedson", "given": "Jamie", "initials": "J"}, {"family": "Skrip", "given": "Laura A", "initials": "LA"}, {"family": "Pedi", "given": "Danielle", "initials": "D"}, {"family": "Abramowitz", "given": "Sharon", "initials": "S", "orcid": "0000-0003-3671-8842", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6bd9191aa8464bb58424225e812d761c.json"}}, {"family": "Carter", "given": "Simone", "initials": "S", "orcid": "0000-0003-3818-3538", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/227e9d375a6649df95425a287f069f01.json"}}, {"family": "Jalloh", "given": "Mohamed F", "initials": "MF"}, {"family": "Funk", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-2842-3406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f03dcbc41884648a4eac5892852899a.json"}}, {"family": "Gobat", "given": "Nina", "initials": "N", "orcid": "0000-0002-1558-557X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78a857e67488494caced727f69c370cf.json"}}, {"family": "Giles-Vernick", "given": "Tamara", "initials": "T", "orcid": "0000-0003-2873-8544", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a47231b81c92440da0d4fdc91b79c108.json"}}, {"family": "Chowell", "given": "Gerardo", "initials": "G"}, {"family": "de Almeida", "given": "Jo\u00e3o Rangel", "initials": "JR", "orcid": "0000-0002-8533-7942", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e0727d3e3ab411987c0dee3120dd1e1.json"}}, {"family": "Elessawi", "given": "Rania", "initials": "R"}, {"family": "Scarpino", "given": "Samuel V", "initials": "SV"}, {"family": "Hammond", "given": "Ross A", "initials": "RA"}, {"family": "Briand", "given": "Sylvie", "initials": "S"}, {"family": "Epstein", "given": "Joshua M", "initials": "JM"}, {"family": "H\u00e9bert-Dufresne", "given": "Laurent", "initials": "L", "orcid": "0000-0002-0008-3673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d7de71d9cc94861a3e846ff6e2ec221.json"}}, {"family": "Althouse", "given": "Benjamin M", "initials": "BM", "orcid": "0000-0002-5464-654X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90d8ce24f2004d148411bb922f38c418.json"}}], "type": "journal article", "published": "2021-06-28", "journal": {"title": "Nat Hum Behav", "issn": "2397-3374", "issn-l": "2397-3374"}, "abstract": "Social and behavioural factors are critical to the emergence, spread and containment of human disease, and are key determinants of the course, duration and outcomes of disease outbreaks. Recent epidemics of Ebola in West Africa and coronavirus disease 2019 (COVID-19) globally have reinforced the importance of developing infectious disease models that better integrate social and behavioural dynamics and theories. Meanwhile, the growth in capacity, coordination and prioritization of social science research and of risk communication and community engagement (RCCE) practice within the current pandemic response provides an opportunity for collaboration among epidemiological modellers, social scientists and RCCE practitioners towards a mutually beneficial research and practice agenda. Here, we provide a review of the current modelling methodologies and describe the challenges and opportunities for integrating them with social science research and RCCE practice. Finally, we set out an agenda for advancing transdisciplinary collaboration for integrated disease modelling and for more robust policy and practice for reducing disease transmission.", "doi": "10.1038/s41562-021-01136-2", "pmid": "34183799", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41562-021-01136-2"}], "notes": [], "created": "2021-06-30T04:58:04.398Z", "modified": "2021-06-30T04:58:04.584Z"}, {"entity": "publication", "iuid": "c810a662405f412a878a8c0e624c3bfb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c810a662405f412a878a8c0e624c3bfb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c810a662405f412a878a8c0e624c3bfb"}}, "title": "Psychological Determinants of COVID-19 Vaccine Acceptance among Healthcare Workers in Kuwait: A Cross-Sectional Study Using the 5C and Vaccine Conspiracy Beliefs Scales.", "authors": [{"family": "Al-Sanafi", "given": "Mariam", "initials": "M"}, {"family": "Sallam", "given": "Malik", "initials": "M"}], "type": "journal article", "published": "2021-06-25", "journal": {"title": "Vaccines", "issn": "2076-393X", "issn-l": null, "volume": "9", "issue": "7", "pages": null}, "abstract": "Acceptance of coronavirus disease 2019 (COVID-19) vaccination appears as a decisive factor necessary to control the ongoing pandemic. Healthcare workers (HCWs) are among the highest risk groups for infection. The current study aimed to evaluate COVID-19 vaccine acceptance among HCWs in Kuwait, with identification of the psychological determinants of COVID-19 vaccine hesitancy. The study was conducted using an online anonymous survey distributed between 18 March 2021 and 29 March 2021. The sampling strategy was convenience-based depending on chain-referral sampling. Psychological determinants of COVID-19 vaccine acceptance were assessed using the 5C subscales and the Vaccine Conspiracy Beliefs Scale (VCBS). The total number of study participants was 1019, with the largest group being physicians (28.7%), pharmacists (20.2%), dentists (16.7%), and nurses (12.5%). The overall rate for COVID-19 vaccine acceptance was 83.3%, with 9.0% who were not willing to accept vaccination and 7.7% who were unsure. The highest rate for COVID-19 vaccine acceptance was seen among dentists (91.2%) and physicians (90.4%), while the lowest rate was seen among nurses (70.1%; p < 0.001). A higher level of COVID-19 vaccine hesitancy was found among females, participants with a lower educational level, and HCWs in the private sector. A preference for mRNA vaccine technology and Pfizer-BioNTech COVID-19 vaccine was found among the majority of participants (62.6% and 69.7%, respectively). COVID-19 vaccine hesitancy was significantly linked to the embrace of vaccine conspiracy beliefs. The highest 5C psychological predictors of COVID-19 vaccine acceptance were high levels of collective responsibility and confidence, and lower levels of constraints and calculation. The VCBS and 5C subscales (except the calculation subscale) showed acceptable levels of predicting COVID-19 vaccine acceptance based on receiver operating characteristic analyses. The participants who depended on social media platforms, TV programs, and news releases as their main sources of knowledge about COVID-19 vaccines showed higher rates of COVID-19 vaccine hesitancy. An overall satisfactory level of COVID-19 vaccine acceptance was seen among HCWs in Kuwait, which was among the highest rates reported globally. However; higher levels of vaccine hesitancy were observed among certain groups (females, nurses and laboratory workers, HCWs in the private sector), which should be targeted with more focused awareness programs. HCWs in Kuwait can play a central role in educating their patients and the general public about the benefits of COVID-19 vaccination to halt the spread of SARS-CoV-2, considering the high rates of vaccine hesitancy observed among the general public in Kuwait and the Middle East.", "doi": "10.3390/vaccines9070701", "pmid": "34202298", "labels": {"Category: Public Health": null, "Type: Review": null}, "xrefs": [{"db": "pii", "key": "vaccines9070701"}], "notes": [], "created": "2021-07-05T14:33:44.839Z", "modified": "2021-07-14T11:17:15.465Z"}, {"entity": "publication", "iuid": "16fd40dde240457d8dbea892eeff3089", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16fd40dde240457d8dbea892eeff3089.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16fd40dde240457d8dbea892eeff3089"}}, "title": "Nuclear factor-kappa B and its role in inflammatory lung disease.", "authors": [{"family": "Alharbi", "given": "Khalid Saad", "initials": "KS"}, {"family": "Fuloria", "given": "Neeraj Kumar", "initials": "NK"}, {"family": "Fuloria", "given": "Shivkanya", "initials": "S"}, {"family": "Rahman", "given": "Sk Batin", "initials": "SB"}, {"family": "Al-Malki", "given": "Waleed Hassan", "initials": "WH"}, {"family": "Javed Shaikh", "given": "Mohammad Arshad", "initials": "MA"}, {"family": "Thangavelu", "given": "Lakshmi", "initials": "L"}, {"family": "Singh", "given": "Sachin K", "initials": "SK"}, {"family": "Rama Raju", "given": "Venkata Sita", "initials": "VS"}, {"family": "Jha", "given": "Niraj Kumar", "initials": "NK"}, {"family": "Chellappan", "given": "Dinesh Kumar", "initials": "DK"}, {"family": "Dua", "given": "Kamal", "initials": "K"}, {"family": "Gupta", "given": "Gaurav", "initials": "G"}], "type": "journal article", "published": "2021-06-25", "journal": {"title": "Chem Biol Interact", "issn": "1872-7786", "pages": "109568", "issn-l": null}, "abstract": "Nuclear factor-kappa B, involved in inflammation, host immune response, cell adhesion, growth signals, cell proliferation, cell differentiation, and apoptosis defense, is a dimeric transcription factor. Inflammation is a key component of many common respiratory disorders, including asthma, COPD, bronchiectasis, and acute respiratory distress syndrome. Many basic transcription factors are found in NF-\u03baB, which is a member of the Rel protein family. Five members of this family c-REL, NF-\u03baB2 (p100/p52), RelA (p65), NF-\u03baB1 (p105/p50), RelB, and RelA (p65) produce 5 transcriptionally active molecules. Proinflammatory cytokines, T lymphocyte, and B lymphocyte cell mitogens, lipopolysaccharides, bacteria, viral proteins, viruses, double-stranded RNA, oxidative stress, physical exertion, various chemotherapeutics are the stimulus responsible for NF-\u03baB activation. NF-\u03baB act as a principal component for several common respiratory illnesses, such as asthma, lung cancer, pulmonary fibrosis, COPD as well as infectious diseases like pneumonia, tuberculosis, COVID-19. Inflammatory lung disease, especially COVID-19, can make NF-\u03baB a key target for drug production.", "doi": "10.1016/j.cbi.2021.109568", "pmid": "34181887", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0009-2797(21)00206-4"}], "notes": [], "created": "2021-06-30T04:57:33.760Z", "modified": "2021-06-30T04:57:44.179Z"}, {"entity": "publication", "iuid": "352d0e4195ea4501abf1525b7513be07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/352d0e4195ea4501abf1525b7513be07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/352d0e4195ea4501abf1525b7513be07"}}, "title": "Lifestyle changes during the first wave of the COVID-19 pandemic: a cross-sectional survey in the Netherlands.", "authors": [{"family": "van der Werf", "given": "Esther T", "initials": "ET"}, {"family": "Busch", "given": "Martine", "initials": "M"}, {"family": "Jong", "given": "Miek C", "initials": "MC"}, {"family": "Hoenders", "given": "H J Rogier", "initials": "HJR"}], "type": "journal article", "published": "2021-06-25", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "1226"}, "abstract": "During the Covid-19 pandemic the Dutch government implemented its so-called 'intelligent lockdown' in which people were urged to leave their homes as little as possible and work from home. This life changing event may have caused changes in lifestyle behaviour, an important factor in the onset and course of diseases. The overarching aim of this study is to determine life-style related changes during the first wave of the COVID-19 pandemic among a representative sample of the adult population in the Netherlands.\r\n\r\nLife-style related changes were studied among a random representative sample of the adult population in the Netherlands using an online survey conducted from 22 to 27 May 2020. Differences in COVID-19-related lifestyle changes between Complementary and Alternative Medicine (CAM) users and non-CAM users were determined. The survey included a modified version of the I-CAM-Q and 26 questions on lifestyle related measures, anxiety, and need for support to maintain lifestyle changes.\r\n\r\n1004 respondents were included in the study, aged between 18 and 88 years (50.7% females). Changes to a healthier lifestyle were observed in 19.3% of the population, mainly due to a change in diet habits, physical activity and relaxation, of whom 56.2% reported to be motivated to maintain this behaviour change in a post-COVID-19 era. Fewer respondents (12.3%) changed into an unhealthier lifestyle. Multivariable logistic regression analyses revealed that changing into a healthier lifestyle was positively associated with the variables 'Worried/Anxious getting COVID-19' (OR: 1.56, 95% C.I. 1.26-1.93), 'CAM use' (OR: 2.04, 95% C.I. 1.38-3.02) and 'stress in relation to financial situation' (OR: 1.89, 95% C.I. 1.30-2.74). 'Age' (OR 18-25: 1.00, OR 25-40: 0.55, 95% C.I. 0.31-0.96, OR 40-55:0.50 95% C.I. 0.28-0.87 OR 55+: 0.1095% C.I. 0.10-0.33), 'stress in relation to health' (OR: 2.52, 95% C.I. 1.64-3.86) and 'stress in relation to the balance work and home' (OR: 1.69, 95% C.I. 1.11-2.57) were found predicting the change into an unhealthier direction.\r\n\r\nThese findings suggest that the coronavirus crisis resulted in a healthier lifestyle in one part and, to a lesser extent, in an unhealthier lifestyle in another part of the Dutch population. Further studies are warranted to see whether this behavioural change is maintained over time, and how different lifestyle factors can affect the susceptibility for and the course of COVID-19.", "doi": "10.1186/s12889-021-11264-z", "pmid": "34172042", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11264-z"}], "notes": [], "created": "2021-06-28T18:11:12.503Z", "modified": "2021-07-14T11:18:29.701Z"}, {"entity": "publication", "iuid": "6aa9df86d6284fd6815f332f6cf4d361", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6aa9df86d6284fd6815f332f6cf4d361.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6aa9df86d6284fd6815f332f6cf4d361"}}, "title": "Extended theory of planned behavior in explaining the intention to COVID-19 vaccination uptake among mainland Chinese university students: an online survey study", "authors": [{"family": "Fan", "given": "Chia Wei", "initials": "CW"}, {"family": "Chen", "given": "I Hua", "initials": "IH", "orcid": "0000-0001-6999-6406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/832b240d9a32490da7c16ec117cf5dbf.json"}}, {"family": "Ko", "given": "Nai Ying", "initials": "NY", "orcid": "0000-0002-3007-2537", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bcdd2c7f1bf84efb9c8b95bcb498c8cb.json"}}, {"family": "Yen", "given": "Cheng Fang", "initials": "CF"}, {"family": "Lin", "given": "Chung Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal-article", "published": "2021-06-25", "journal": {"title": "Human Vaccines & Immunotherapeutics", "issn": "2164-5515", "pages": "1-8", "issn-l": null}, "abstract": null, "doi": "10.1080/21645515.2021.1933687", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:12:19.308Z", "modified": "2021-06-28T18:12:19.466Z"}, {"entity": "publication", "iuid": "2e957843514442c6a758bf3ed5620021", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e957843514442c6a758bf3ed5620021.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e957843514442c6a758bf3ed5620021"}}, "title": "COVID-19 Transmission due to Mass Mobility Before and After the Largest Festival in Bangladesh: An Epidemiologic Study.", "authors": [{"family": "Rahman", "given": "Farah Naz", "initials": "FN"}, {"family": "Rahman", "given": "A K M Fazlur", "initials": "AKMF"}, {"family": "Iwuagwu", "given": "Anthony Obinna", "initials": "AO"}, {"family": "Dalal", "given": "Koustuv", "initials": "K"}], "type": "journal article", "published": "2021-06-25", "journal": {"title": "Inquiry", "issn": "1945-7243", "issn-l": null, "volume": "58", "issue": null, "pages": "469580211023464"}, "abstract": "Festivals traditionally result in mass public mobility from large cities to rural or semi-urban areas in low- and middle-Income Countries (LMIC), which are inadequately prepared for tackling the consequences of the COVID-19 pandemic. This study aimed to explore the trend of COVID-19 infection in a peripheral region of Bangladesh during one of the largest festivals to develop an evidence-based hypothesis for its influence on the transmission rate of COVID-19. This study conducted a quantitative analysis of secondary data on COVID-19 collected from the Directorate General of Health Services Bangladesh (DGHS) and divisional director's office in the Mymensingh division. To explore the influence of one of the biggest festivals (Eid-ul-Adha) on the trend of COVID-19 infection, we analyzed data from a week before the festival to 2 weeks following the festival. The infection rate (positive cases per million of the population) and the test positivity rate (positive cases among the total number of conducted diagnostic tests) of each day during this period were calculated both for the Mymensingh region and national level. Both the test positivity rate (TPR) and infection rates in the Mymensingh region demonstrated an increasing trend. The mean test positivity rate of the Mymensingh region on the week before the festival was 9.5%. It increased to a mean test positivity rate of 13% in the following week and further rose to a rate of 17% in the next week. The infection rate of Mymensingh also increased more than 2 folds from the day of the festival (2.0-5.3 cases per million) within the next 2 weeks. The TPR and infection rate on the national level remained similar throughout the study period. Mass mobility during Eid-ul-Adha influences the increased transmission of COVID-19 among the peripheral regions of Bangladesh from the central capital city Dhaka. The findings will help policymakers plan and implement travel restrictions during festivals during the pandemic in LMICs.", "doi": "10.1177/00469580211023464", "pmid": "34166134", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:15:05.881Z", "modified": "2021-07-14T11:19:15.484Z"}, {"entity": "publication", "iuid": "234fc3388f0546a9a405eafcba15f5bb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/234fc3388f0546a9a405eafcba15f5bb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/234fc3388f0546a9a405eafcba15f5bb"}}, "title": "Suggested treatment of serious complications to Covid\u201019 vaccination with IdeS, a bacterial antibody\u2010cleaving enzyme", "authors": [{"family": "Kahn", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-5566-6350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42eda71f3775400599febc10a4e7359c.json"}}, {"family": "Shannon", "given": "Oonagh", "initials": "O", "orcid": "0000-0001-8291-8189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7fad6031e2f4a84a8ede77911d3c542.json"}}, {"family": "Bj\u00f6rck", "given": "Lars", "initials": "L"}], "type": "journal-article", "published": "2021-06-24", "journal": {"title": "J Thromb Haemost", "issn": "1538-7836", "issn-l": null}, "abstract": null, "doi": "10.1111/jth.15433", "pmid": null, "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:15:49.076Z", "modified": "2021-06-30T05:08:56.397Z"}, {"entity": "publication", "iuid": "0ac0332baa1f45c4aa00387bcc5c8b14", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ac0332baa1f45c4aa00387bcc5c8b14.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ac0332baa1f45c4aa00387bcc5c8b14"}}, "title": "Risk of SARS-CoV-2 infection and subsequent hospital admission and death at different time intervals since first dose of COVID-19 vaccine administration, Italy, 27 December 2020 to mid-April 2021", "authors": [{"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Spila Alegiani", "given": "Stefania", "initials": "S"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Filia", "given": "Antonietta", "initials": "A"}, {"family": "Massari", "given": "Marco", "initials": "M"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Tallon", "given": "Marco", "initials": "M"}, {"family": "Proietti", "given": "Valeria", "initials": "V"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Puopolo", "given": "Maria", "initials": "M"}, {"family": "Spuri", "given": "Matteo", "initials": "M"}, {"family": "Morciano", "given": "Cristina", "initials": "C"}, {"family": "D\u2019Ancona", "given": "Fortunato (Paolo)", "initials": "F("}, {"family": "Da Cas", "given": "Roberto", "initials": "R"}, {"family": "Battilomo", "given": "Serena", "initials": "S"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Menniti-Ippolito", "given": "Francesca", "initials": "F"}, {"family": "None", "given": "", "initials": ""}, {"family": "None", "given": "", "initials": ""}], "type": "journal-article", "published": "2021-06-24", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "25", "pages": null}, "abstract": null, "doi": "10.2807/1560-7917.es.2021.26.25.2100507", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:13:29.956Z", "modified": "2021-07-14T11:16:12.655Z"}, {"entity": "publication", "iuid": "16fa3d7c7cdc4a339271cff87092d7c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16fa3d7c7cdc4a339271cff87092d7c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16fa3d7c7cdc4a339271cff87092d7c0"}}, "title": "Evolution, Correlation, Structural Impact and Dynamics of Emerging SARS-CoV-2 Variants.", "authors": [{"family": "Spratt", "given": "Austin N", "initials": "AN"}, {"family": "Kannan", "given": "Saathvik R", "initials": "SR"}, {"family": "Woods", "given": "Lucas T", "initials": "LT"}, {"family": "Weisman", "given": "Gary A", "initials": "GA"}, {"family": "Quinn", "given": "Thomas P", "initials": "TP"}, {"family": "Lorson", "given": "Christian L", "initials": "CL"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}, {"family": "Singh", "given": "Kamal", "initials": "K"}], "type": "journal article", "published": "2021-06-24", "journal": {"title": "Comput Struct Biotechnol J", "issn": "2001-0370", "issn-l": "2001-0370"}, "abstract": "Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infections remain unmanageable in some parts of the world. As with other RNA viruses, mutations in the SARS-CoV-2 gene have been continuously evolving. Recently, four variants have been identified, B.1.1.7, B.1.351, P.1 and CAL.20C. These variants appear to be more infectious and transmissible than the original Wuhan-Hu-1 virus. Using a combination of bioinformatics and structural analyses, we show that the new SARS-CoV-2 variants emerged in the background of an already known Spike protein mutation D614G together with another mutation P323L in the RNA polymerase of SARS-CoV-2. The phylogenetic analysis showed that the CAL.20C and B.1.351 shared one common ancestor, whereas the B.1.1.7 and P.1 shared a different ancestor. Structural comparisons did not show any significant difference between the wild-type and mutant ACE2/Spike complexes. Structural analysis indicated that the N501Y mutation may increase hydrophobic interactions at the ACE2/Spike interface. However, reported greater binding affinity of N501Y Spike with ACE2 does not seem to be entirely due to increased hydrophobic interactions, given that Spike mutation R417T in P.1 or K417N in B.1.351 results in the loss of a salt-bridge interaction between ACE2 and S-RBD. The calculated change in free energy did not provide a clear trend of S protein stability of mutations in the variants. As expected, we show that the CAL.20C generally migrated from the west coast to the east coast of the USA. Taken together, the analyses suggest that the evolution of variants and their infectivity is complex and may depend upon many factors.", "doi": "10.1016/j.csbj.2021.06.037", "pmid": "34188776", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2001-0370(21)00275-0"}, {"db": "pmc", "key": "PMC8225291"}], "notes": [], "created": "2021-07-05T14:24:05.957Z", "modified": "2021-07-05T14:24:05.969Z"}, {"entity": "publication", "iuid": "b8075ce5a3464e22a6ce2f9b1cfdc626", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8075ce5a3464e22a6ce2f9b1cfdc626.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8075ce5a3464e22a6ce2f9b1cfdc626"}}, "title": "Detection and viral RNA shedding of SARS-CoV-2 in respiratory specimens relative to symptom onset among COVID-19 patients in Bavaria, Germany.", "authors": [{"family": "Woudenberg", "given": "Tom", "initials": "T", "orcid": "0000-0002-5675-7470", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9992ee28624349caaa1984823c705bf4.json"}}, {"family": "Eberle", "given": "Ute", "initials": "U"}, {"family": "Marosevic", "given": "Durdica", "initials": "D"}, {"family": "Liebl", "given": "Bernhard", "initials": "B"}, {"family": "Ackermann", "given": "Nikolaus", "initials": "N"}, {"family": "Katz", "given": "Katharina", "initials": "K"}, {"family": "Sing", "given": "Andreas", "initials": "A", "orcid": "0000-0003-1619-6047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3be5645dc94443809ebedaef2961294a.json"}}, {"family": "Bavarian SARS-CoV-2-Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-06-23", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "issn-l": null, "volume": "149", "issue": null, "pages": "e150"}, "abstract": "We assessed severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) reverse transcriptase-polymerase chain reaction (RT-PCR) diagnostic sensitivity and cycle threshold (Ct) values relative to symptom onset in symptomatic coronavirus disease-2019 (COVID-19) patients from Bavaria, Germany, of whom a subset was repeatedly tested. Locally weighted scatterplot smoothing method was used to assess the relationship between symptom onset and Ct-values. Kaplan-Meier plots were used to visualise the empirical probability of detecting viral ribonucleic acid (RNA) over time and estimate the time until clearance of viral RNA among the repeatedly tested patients. Among 721 reported COVID-19 cases, the viral RNA was detected in specimens taken between three days before and up to 48 days after symptom onset. The mean Ct-value was 28.6 (95% confidence interval (CI) 28.2-29.0) with the lowest mean Ct-value (26.2) observed two days after symptom onset. Up to 7 days after symptom onset, the diagnostic sensitivity of the RT-PCR among repeatedly sampled patients (n = 208) remained above 90% and decreased to 50% at day 12 (95% CI 10.5-21.5). Our data provide valuable estimates to optimise the timing of sampling of individuals for SARS-CoV-2 detection. A considerable proportion of specimens sampled before symptom onset had Ct-values comparable with Ct-values after symptom onset, suggesting the probability of presymptomatic transmission.", "doi": "10.1017/S0950268821001345", "pmid": "34158139", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8314058"}, {"db": "pii", "key": "S0950268821001345"}], "notes": [], "created": "2021-06-28T18:18:35.200Z", "modified": "2023-06-19T15:23:52.921Z"}, {"entity": "publication", "iuid": "66f436ea105e4dd29af69fbafc5e18c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66f436ea105e4dd29af69fbafc5e18c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66f436ea105e4dd29af69fbafc5e18c5"}}, "title": "COVseq is a cost-effective workflow for mass-scale SARS-CoV-2 genomic surveillance.", "authors": [{"family": "Simonetti", "given": "Michele", "initials": "M", "orcid": "0000-0003-3322-1697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1382a34459c64b839f1d7889625c374c.json"}}, {"family": "Zhang", "given": "Ning", "initials": "N", "orcid": "0000-0002-6430-4236", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/866db18024634b20af9872a97c716be2.json"}}, {"family": "Harbers", "given": "Luuk", "initials": "L", "orcid": "0000-0003-3910-6497", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2f9ea2325db4f6fab536fe923f90bf3.json"}}, {"family": "Milia", "given": "Maria Grazia", "initials": "MG"}, {"family": "Brossa", "given": "Silvia", "initials": "S"}, {"family": "Huong Nguyen", "given": "Thi Thu", "initials": "TT", "orcid": "0000-0002-9089-7370", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b366997bbc1645828d0ea10cc1c8ad0e.json"}}, {"family": "Cerutti", "given": "Francesco", "initials": "F", "orcid": "0000-0003-0480-8296", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05159eca599748f6b79857bb726200c1.json"}}, {"family": "Berrino", "given": "Enrico", "initials": "E"}, {"family": "Sapino", "given": "Anna", "initials": "A"}, {"family": "Bienko", "given": "Magda", "initials": "M", "orcid": "0000-0002-6499-9082", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa0cd262fa184872b92d7589a2cc2d62.json"}}, {"family": "Sottile", "given": "Antonino", "initials": "A"}, {"family": "Ghisetti", "given": "Valeria", "initials": "V", "orcid": "0000-0002-4698-598X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3aebeae45cb44e4691c4d3fc468f8699.json"}}, {"family": "Crosetto", "given": "Nicola", "initials": "N", "orcid": "0000-0002-3019-6978", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc7960c369064c89a193bd94b598d12d.json"}}], "type": "journal article", "published": "2021-06-23", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "3903"}, "abstract": "While mass-scale vaccination campaigns are ongoing worldwide, genomic surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to monitor the emergence and global spread of viral variants of concern (VOC). Here, we present a streamlined workflow-COVseq-which can be used to generate highly multiplexed sequencing libraries compatible with Illumina platforms from hundreds of SARS-CoV-2 samples in parallel, in a rapid and cost-effective manner. We benchmark COVseq against a standard library preparation method (NEBNext) on 29 SARS-CoV-2 positive samples, reaching 95.4% of concordance between single-nucleotide variants detected by both methods. Application of COVseq to 245 additional SARS-CoV-2 positive samples demonstrates the ability of the method to reliably detect emergent VOC as well as its compatibility with downstream phylogenetic analyses. A cost analysis shows that COVseq could be used to sequence thousands of samples at less than 15 USD per sample, including library preparation and sequencing costs. We conclude that COVseq is a versatile and scalable method that is immediately applicable for SARS-CoV-2 genomic surveillance and easily adaptable to other pathogens such as influenza viruses.", "doi": "10.1038/s41467-021-24078-9", "pmid": "34162869", "labels": {"Research Area: Viral sequence evolution": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-24078-9"}, {"db": "pmc", "key": "PMC8222401"}], "notes": [], "created": "2021-06-23T11:59:06.941Z", "modified": "2021-12-11T05:55:57.605Z"}, {"entity": "publication", "iuid": "be10034a6b7e4a398b1da679f17fedba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be10034a6b7e4a398b1da679f17fedba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be10034a6b7e4a398b1da679f17fedba"}}, "title": "Who should be tested in a pandemic? Ethical considerations.", "authors": [{"family": "Hansson", "given": "Sven Ove", "initials": "SO", "orcid": "0000-0003-0071-3919", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44c820ae26d9495684ea585732835a69.json"}}, {"family": "Helgesson", "given": "Gert", "initials": "G"}, {"family": "Juth", "given": "Niklas", "initials": "N"}], "type": "journal article", "published": "2021-06-22", "journal": {"title": "BMC Med Ethics", "issn": "1472-6939", "volume": "22", "issue": "1", "pages": "76", "issn-l": null}, "abstract": "In the initial phase of the Covid-19 pandemic, difficult decisions had to be made on the allocation of testing resources. Similar situations can arise in future pandemics. Therefore, careful consideration of who should be tested is an important part of pandemic preparedness. We focus on four ethical aspects of that problem: how to prioritize scarce testing resources, the regulation of commercial direct-to-consumer test services, testing of unauthorized immigrants, and obligatory testing.\n\nThe distribution of scarce resources for testing: We emphasize the use of needs-based criteria, but also acknowledge the importance of choosing a testing strategy that contributes efficiently to stopping the overall spread of the disease. Commercial direct-to-consumer test services: Except in cases of acute scarcity, such services will in practice have to be allowed. We propose that they should be subject to regulation that ensures test quality and adequate information to users. Testing of unauthorized immigrants, their children and other people with unclear legal status: Like everyone else, these individuals may be in need of testing, and it is in society's interest to reach them with testing in order to stop the spread of the disease. A society that offers comprehensive medical services to unauthorized immigrants is in a much better position to reach them in a pandemic than a society that previously excluded them from healthcare. Obligatory testing: While there are often strong reasons for universal testing in residential areas or on workplaces, there are in most cases better ways to achieve testing coverage than to make testing mandatory.\n\nIn summary, we propose (1) decision-making primarily based on needs-based criteria, (2) strict regulation but not prohibition of direct-to-consumer test services, (3) test services offered to unauthorized immigrants, preferably as part of comprehensive medical services, and (4) broad outreach of testing services whenever possible, but in general not obligatory testing.", "doi": "10.1186/s12910-021-00640-4", "pmid": "34158041", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12910-021-00640-4"}, {"db": "pmc", "key": "PMC8218570"}], "notes": [], "created": "2021-06-28T18:18:53.622Z", "modified": "2021-06-28T18:18:53.673Z"}, {"entity": "publication", "iuid": "906776760124487f9e2989bb99a3f45d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/906776760124487f9e2989bb99a3f45d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/906776760124487f9e2989bb99a3f45d"}}, "title": "Recent MMR vaccination in health care workers and Covid-19: A test negative case-control study.", "authors": [{"family": "Lundberg", "given": "Lisa", "initials": "L"}, {"family": "Bygdell", "given": "Maria", "initials": "M"}, {"family": "Stukat von Feilitzen", "given": "Gustaf", "initials": "G"}, {"family": "Woxenius", "given": "Susanne", "initials": "S"}, {"family": "Ohlsson", "given": "Claes", "initials": "C"}, {"family": "Kindblom", "given": "Jenny M", "initials": "JM"}, {"family": "Leach", "given": "Susannah", "initials": "S"}], "type": "journal article", "published": "2021-06-22", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null}, "abstract": "It has been hypothesised that the measles-mumps-rubella (MMR) vaccine may afford cross-protection against SARS-CoV-2 which may contribute to the wide variability in disease severity of Covid-19.\n\nWe employed a test negative case-control study, utilising a recent measles outbreak during which many healthcare workers received the MMR vaccine, to investigate the potential protective effect of MMR against SARS-CoV-2 in 5905 subjects (n = 805 males, n = 5100 females).\n\nThe odds ratio for testing positive for SARS-CoV-2, in recently MMR-vaccinated compared to not recently MMR-vaccinated individuals was 0.91 (95% CI 0.76, 1.09). An interaction analysis showed a significant interaction for sex. After sex-stratification, the odds ratio for testing positive for males was 0.43 (95% CI 0.24, 0.79, P = 0.006), and 1.01 (95% CI 0.83, 1.22, P = 0.92) for females.\n\nOur results indicate that there may be a protective effect of the MMR vaccine against SARS-CoV-2 in males but not females.", "doi": "10.1016/j.vaccine.2021.06.045", "pmid": "34187707", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(21)00795-7"}, {"db": "pmc", "key": "PMC8216866"}], "notes": [], "created": "2021-07-05T14:22:17.192Z", "modified": "2021-07-05T14:22:40.368Z"}, {"entity": "publication", "iuid": "abf861e7ee84401fa61a6a136b81d21b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abf861e7ee84401fa61a6a136b81d21b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abf861e7ee84401fa61a6a136b81d21b"}}, "title": "Obesity Strongly Predicts COVID-19-Related Major Clinical Adverse Events in Coptic Clergy.", "authors": [{"family": "Henein", "given": "Michael Y", "initials": "MY", "orcid": "0000-0002-6089-5614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe79bb10eb4348948599443b7b396faf.json"}}, {"family": "Byty\u00e7i", "given": "Ibadete", "initials": "I", "orcid": "0000-0002-8996-4257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba2f218876104573a8e529b1c2b6f671.json"}}, {"family": "Nicoll", "given": "Rachel", "initials": "R"}, {"family": "Shenouda", "given": "Rafik", "initials": "R"}, {"family": "Ayad", "given": "Sherif", "initials": "S", "orcid": "0000-0002-1737-0142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6bd437e0e8d54056959e5077471e1542.json"}}, {"family": "Vancheri", "given": "Federico", "initials": "F"}, {"family": "Cameli", "given": "Matteo", "initials": "M", "orcid": "0000-0003-3872-8964", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e64899d051a84cd8a0cac5f503e03251.json"}}], "type": "journal article", "published": "2021-06-22", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "10", "issue": "13", "issn-l": "2077-0383"}, "abstract": "The Coptic clergy, due to their specific work involving interaction with many people, could be subjected to increased risk of infection from COVID-19. The aim of this study, a sub-study of the COVID-19-CVD international study of the impact of the pandemic on the cardiovascular system, was to assess the prevalence of COVID-19 among Coptic priests and to identify predictors of clinical adverse events.\n\nParticipants were geographically divided into three groups: Group-I: Europe and USA, Group II: Northern Egypt, and Group III: Southern Egypt. Participants' demographic indices, cardiovascular risk factors, possible source of infection, number of liturgies, infection management, and major adverse events (MAEs), comprising death, or mechanical ventilation, were assessed.\n\nOut of the 1570 clergy serving in 25 dioceses, 255 (16.2%) were infected. Their mean age was 49.5 \u00b1 12 years and mean weekly number of liturgies was 3.44 \u00b1 1.0. The overall prevalence rate was 16.2% and did not differ between Egypt as a whole and overseas (p = 0.23). Disease prevalence was higher in Northern Egypt clergy compared with Europe and USA combined (18.4% vs. 12.1%, p = 0.03) and tended to be higher than in Southern Egypt (18.4% vs. 13.6%, p = 0.09). Ten priests (3.92%) died of COVID-19-related complications, and 26 (10.2) suffered a MAE. The clergy from Southern Egypt were more obese, but the remaining risk factors were less prevalent compared with those in Europe and USA (p = 0.01). In multivariate analysis, obesity (OR = 4.180; 2.479 to 12.15; p = 0.01), age (OR = 1.055; 0.024 to 1.141; p = 0.02), and systemic hypertension (OR = 1.931; 1.169 to 2.004; p = 0.007) predicted MAEs. Obesity was the most powerful independent predictor of MAE in Southern Egypt and systemic hypertension in Northern Egypt (p < 0.05 for both).\n\nObesity is very prevalent among Coptic clergy and seems to be the most powerful independent predictor of major COVID-19-related adverse events. Coptic clergy should be encouraged to follow the WHO recommendations for cardiovascular disease and COVID-19 prevention.", "doi": "10.3390/jcm10132752", "pmid": "34206658", "labels": {"Type: Review": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "jcm10132752"}], "notes": [], "created": "2021-07-05T14:36:08.009Z", "modified": "2021-07-05T14:36:08.112Z"}, {"entity": "publication", "iuid": "711c5ab1909448a5aef6875fa091021f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/711c5ab1909448a5aef6875fa091021f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/711c5ab1909448a5aef6875fa091021f"}}, "title": "Fear of COVID-19 and Perceived COVID-19 Infectability Supplement Theory of Planned Behavior to Explain Iranians' Intention to Get COVID-19 Vaccinated.", "authors": [{"family": "Yahaghi", "given": "Rafat", "initials": "R"}, {"family": "Ahmadizade", "given": "Safie", "initials": "S"}, {"family": "Fotuhi", "given": "Razie", "initials": "R"}, {"family": "Taherkhani", "given": "Elham", "initials": "E"}, {"family": "Ranjbaran", "given": "Mehdi", "initials": "M", "orcid": "0000-0002-0313-3373", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6b9820cfd99430a938c9653d46f6322.json"}}, {"family": "Buchali", "given": "Zeinab", "initials": "Z"}, {"family": "Jafari", "given": "Robabe", "initials": "R"}, {"family": "Zamani", "given": "Narges", "initials": "N"}, {"family": "Shahbazkhania", "given": "Azam", "initials": "A"}, {"family": "Simiari", "given": "Hengame", "initials": "H"}, {"family": "Rahmani", "given": "Jalal", "initials": "J"}, {"family": "Yazdi", "given": "Nahid", "initials": "N"}, {"family": "Alijani", "given": "Hashem", "initials": "H"}, {"family": "Poorzolfaghar", "given": "Leila", "initials": "L"}, {"family": "Rajabi", "given": "Fatemeh", "initials": "F"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-06-22", "journal": {"title": "Vaccines", "issn": "2076-393X", "issn-l": null, "volume": "9", "issue": "7", "pages": "684"}, "abstract": "One of the most efficient methods to control the high infection rate of the coronavirus disease 2019 (COVID-19) is to have a high coverage of COVID-19 vaccination worldwide. Therefore, it is important to understand individuals' intention to get COVID-19 vaccinated. The present study applied the Theory of Planned Behavior (TPB) to explain the intention to get COVID-19 vaccinated among a representative sample in Qazvin, Iran. The TPB uses psychological constructs of attitude, subjective norm, and perceived behavioral control to explain an individual's intention to perform a behavior. Fear and perceived infectability were additionally incorporated into the TPB to explain the intention to get COVID-19 vaccinated. Utilizing multistage stratified cluster sampling, 10,843 participants (4092 males; 37.7%) with a mean age of 35.54 years (SD = 12.00) completed a survey. The survey assessed TPB constructs (including attitude, subjective norm, perceived behavioral control, and intention related to COVID-19 vaccination) together with fear of COVID-19 and perceived COVID-19 infectability. Structural equation modeling (SEM) was performed to examine whether fear of COVID-19, perceived infectability, and the TPB constructs explained individuals' intention to get COVID-19 vaccinated. The SEM demonstrated satisfactory fit (comparative fit index = 0.970; Tucker-Lewis index = 0.962; root mean square error of approximation = 0.040; standardized root mean square residual = 0.050). Moreover, perceived behavioral control, subjective norm, attitude, and perceived COVID-19 infectability significantly explained individuals' intention to get COVID-19 vaccinated. Perceived COVID-19 infectability and TPB constructs were all significant mediators in the relationship between fear of COVID-19 and intention to get COVID-19 vaccinated. Incorporating fear of COVID-19 and perceived COVID-19 infectability effectively into the TPB explained Iranians' intention to get COVID-19 vaccinated. Therefore, Iranians who have a strong belief in Muslim religion may improve their intention to get COVID-19 vaccinated via these constructs.", "doi": "10.3390/vaccines9070684", "pmid": "34206226", "labels": {"Category: Public Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8310138"}, {"db": "pii", "key": "vaccines9070684"}], "notes": [], "created": "2021-07-05T14:35:28.108Z", "modified": "2023-06-19T15:21:14.367Z"}, {"entity": "publication", "iuid": "a072af27feb64a60bed14b2e4089a3d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a072af27feb64a60bed14b2e4089a3d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a072af27feb64a60bed14b2e4089a3d4"}}, "title": "Adapting the Motors of Influenza Vaccination Acceptance Scale into the Motors of COVID-19 Vaccination Acceptance Scale: Psychometric evaluation among mainland Chinese university students.", "authors": [{"family": "Chen", "given": "I-Hua", "initials": "IH"}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Ko", "given": "Nai-Ying", "initials": "NY"}, {"family": "Yen", "given": "Cheng-Fang", "initials": "CF"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-06-22", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null}, "abstract": "COVID-19 continues to ravage the world with economies and life significantly and negatively affected. Fortunately, there has been significant progress in the production of vaccines to stem the infection. However, with controversies and myths surrounding vaccinations, it is timely to examine individuals' willingness to vaccinate. The present study adapted the Motors of Influenza Vaccination Acceptance Scale (MoVac-Flu Scale) into the Motors of COVID-19 Vaccination Acceptance Scale (MoVac-COVID19S) for validation and assessed the acceptance of COVID-19 vaccination utilizing the cognitive model of empowerment (CME).\n\nA total of 3145 university students (mean age = 20.80 years; SD = 2.09) were recruited for the present study between January 5 and 16, 2021. Two MoVac-COVID19S scales (9-item and 12-item) were adapted from the MoVac-Flu Scale, an instrument developed using CME. Psychometric tests were conducted to ascertain reliability and validity properties.\n\nThe findings indicated that the MoVac-COVID19S had high internal consistency in both the 9-item version (\u03c9 = 0.921) and 12-item version (\u03c9 = 0.898). The factor structure of the MoVac-COVID19S (9-item and 12-item versions) corresponded well with CME theory. All the fit indices were satisfactory (comparative fit index = 0.984, Tucker-Lewis index = 0.971, root mean square error of approximation = 0.088, standardized root mean square residual = 0.058) but the 9-item MoVac-COVID had better fit indices than the 12-item MoVac-COVID due to the negative wording effects existing in the 12-item MoVac-COVID19S. The scale had satisfactory known-group validity in both 9-item and 12-item versions.\n\nThe MoVac-COVID19S has promising psychometric properties based on internal consistency, factor structure, and known-group validity.", "doi": "10.1016/j.vaccine.2021.06.044", "pmid": "34217571", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(21)00794-5"}], "notes": [], "created": "2021-07-05T15:04:14.711Z", "modified": "2021-07-05T15:04:14.722Z"}, {"entity": "publication", "iuid": "d2e4dfecaa2b457ca2deddac6fa256e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d2e4dfecaa2b457ca2deddac6fa256e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d2e4dfecaa2b457ca2deddac6fa256e1"}}, "title": "Problems associated with mass border testing of COVID-19.", "authors": [{"family": "Grun\u00e9r", "given": "Mathias", "initials": "M"}, {"family": "Nordberg", "given": "Marika", "initials": "M"}, {"family": "L\u00f6nnroth", "given": "Knut", "initials": "K"}], "type": "journal article", "published": "2021-06-19", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": null, "issue": null, "pages": "14034948211023659"}, "abstract": "We evaluated the yield of exit screening for SARS-Cov-2 performed in order for travellers to meet entry requirements to Sweden. Among 472 people screened, no infectious case of COVID-19 was detected, while two previously known cases were redetected after having already completed isolation. Our data suggest that depending on the epidemiological situation in the area of departure, border screening can lead to very low positive predictive values and very high costs per relevant case detected.", "doi": "10.1177/14034948211023659", "pmid": "34148440", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:27:36.293Z", "modified": "2021-07-14T11:05:48.211Z"}, {"entity": "publication", "iuid": "c47615463a5942ea9282f007e05a3647", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c47615463a5942ea9282f007e05a3647.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c47615463a5942ea9282f007e05a3647"}}, "title": "Organizational Support Experiences of Care Home and Home Care Staff in Sweden, Italy, Germany and the United Kingdom during the COVID-19 Pandemic", "authors": [{"family": "Lethin", "given": "Connie", "initials": "C", "orcid": "0000-0002-2523-8440", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e4dbde29c2949e09fdeff309bf402e2.json"}}, {"family": "Kenkmann", "given": "Andrea", "initials": "A", "orcid": "0000-0002-9252-2345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5447bed983d94bd3b6ba83eee314ec89.json"}}, {"family": "Chiatti", "given": "Carlos", "initials": "C", "orcid": "0000-0003-4810-9630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7b5ce4271844684965d8c4abe0cd66c.json"}}, {"family": "Christensen", "given": "Jonas", "initials": "J", "orcid": "0000-0003-0428-2001", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/66ccc78bb50f4b37a7365eb8154419a9.json"}}, {"family": "Backhouse", "given": "Tamara", "initials": "T", "orcid": "0000-0001-8194-4174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64556c498dd94570ae0a35f2ae892328.json"}}, {"family": "Killett", "given": "Anne", "initials": "A"}, {"family": "Fisher", "given": "Oliver", "initials": "O", "orcid": "0000-0003-2787-2899", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6f8c5634b75c486b9c00ab54738c43cd.json"}}, {"family": "Malmgren F\u00e4nge", "given": "Agneta", "initials": "A", "orcid": "0000-0002-3165-1856", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b47b1c9adc81409ba189a6cec7643f4a.json"}}], "type": "journal-article", "published": "2021-06-19", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "issn-l": null, "volume": "9", "issue": "6", "pages": "767"}, "abstract": "The COVID-19 pandemic has affected care workers all over the globe, as older and more vulnerable people face a high risk of developing severe symptoms and dying from the virus infection. The aim of this study was to compare staff experiences of stress and anxiety as well as internal and external organizational support in Sweden, Italy, Germany, and the United Kingdom (UK) in order to determine how care staff were affected by the pandemic. A 29-item online questionnaire was used to collect data from care staff respondents: management (n = 136), nurses (n = 132), nursing assistants (n = 195), and other healthcare staff working in these organizations (n = 132). Stress and anxiety levels were highest in the UK and Germany, with Swedish staff showing the least stress. Internal and external support only partially explain the outcomes. Striking discrepancies between different staff groups' assessment of organizational support as well as a lack of staff voice in the UK and Germany could be key factors in understanding staff's stress levels during the pandemic. Structural, political, cultural, and economic factors play a significant role, not only factors within the care organization or in the immediate context.", "doi": "10.3390/healthcare9060767", "pmid": "34205430", "labels": {"Category: Public Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8233956"}, {"db": "pii", "key": "healthcare9060767"}], "notes": [], "created": "2021-07-05T14:34:33.693Z", "modified": "2023-06-19T07:30:08.818Z"}, {"entity": "publication", "iuid": "73dc7c5305684104bbfa82bbc77ab961", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/73dc7c5305684104bbfa82bbc77ab961.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/73dc7c5305684104bbfa82bbc77ab961"}}, "title": "Stable IgG-antibody levels in patients with mild SARS-CoV-2 infection", "authors": [{"family": "\u00c5kerlund", "given": "Thomas", "initials": "T"}, {"family": "Zakikhany", "given": "Katherina", "initials": "K"}, {"family": "L\u00f6fstr\u00f6m", "given": "Charlotta", "initials": "C"}, {"family": "Lindmark", "given": "Evelina", "initials": "E"}, {"family": "K\u00e4llberg", "given": "Henrik", "initials": "H"}, {"family": "Elofsson", "given": "Ulla", "initials": "U"}, {"family": "Cederbrant", "given": "Karin", "initials": "K"}, {"family": "Nygren", "given": "Erik", "initials": "E"}, {"family": "Kallin", "given": "Anders", "initials": "A"}, {"family": "Lagerqvist", "given": "Nina", "initials": "N"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Wollberg", "given": "Anna Ridderstad", "initials": "AR"}, {"family": "Bj\u00f6rndal", "given": "\u00c5sa Szekely", "initials": "\u00c5S"}], "type": "posted-content", "published": "2021-06-18", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.06.16.21258960", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-18T16:39:34.128Z", "modified": "2021-11-18T16:39:50.737Z"}, {"entity": "publication", "iuid": "22939049e0964fe4910f0c36ed045304", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/22939049e0964fe4910f0c36ed045304.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/22939049e0964fe4910f0c36ed045304"}}, "title": "Everyday life in a Swedish nursing home during the COVID-19 pandemic: a qualitative interview study with persons 85 to 100 years.", "authors": [{"family": "Lood", "given": "Qarin", "initials": "Q", "orcid": "0000-0002-6187-0929", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/205301c28ae14612b3df0603d39adabb.json"}}, {"family": "Haak", "given": "Maria", "initials": "M"}, {"family": "Dahlin-Ivanoff", "given": "Synneve", "initials": "S"}], "type": "journal article", "published": "2021-06-18", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "6", "pages": "e048503"}, "abstract": "To understand and report on the impact of the COVID-19 pandemic on the everyday lives of frail older persons living in nursing homes by exploring their experiences of how the pandemic-related restrictions had influenced them and in what way.\n\nEmpirical qualitative interview study.\n\nA publicly run nursing home in an urban area in Sweden in June 2020. The nursing home had visitor restrictions, cancelled activities and physical distancing requirements since March 2020.\n\nA total of 10 persons, 85-100 years, living in a Swedish nursing home during the COVID-19 pandemic, were recruited through nursing home management and interviewed in June 2020 using medically approved visors and physical distancing.\n\nInterviews were analysed using thematic analysis, which involves familiarisation, coding and definition of themes. Transcripts were coded into data-driven categories before being organised into categories that described and explained the data.\n\nThe analysis resulted in the main theme 'It is like living in a bubble', that describes everyday life in the nursing home during the pandemic as a world of its own in which the older persons felt both protected and isolated. This is described in four subthemes: living 1 day at a time, without fear of the virus; feeling taken care of; having limited freedom and missing out on the little extras.\n\nContributing to the growing area of COVID-19-related research, our findings provide novel insights into how pandemic-related restrictions in nursing homes represent a risk of isolating older people from the outside world and diminishing their freedom. Put in relation to the previous research, these findings could be applied beyond the pandemic, to develop research and practice that puts focus on how to support older people to decide for themselves how to spend the rest of their lives.", "doi": "10.1136/bmjopen-2020-048503", "pmid": "34145018", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8214988"}, {"db": "pii", "key": "bmjopen-2020-048503"}], "notes": [], "created": "2021-06-28T18:28:49.224Z", "modified": "2023-06-19T15:05:00.460Z"}, {"entity": "publication", "iuid": "95767140345346129cb142e2870772c7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95767140345346129cb142e2870772c7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95767140345346129cb142e2870772c7"}}, "title": "The Impact of the Renin-Angiotensin-Aldosterone System on Inflammation, Coagulation, and Atherothrombotic Complications, and to Aggravated COVID-19.", "authors": [{"family": "Ekholm", "given": "M", "initials": "M"}, {"family": "Kahan", "given": "T", "initials": "T"}], "type": "journal article", "published": "2021-06-17", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "12", "pages": "640185", "issn-l": "1663-9812"}, "abstract": "Atherosclerosis is considered a disease caused by a chronic inflammation, associated with endothelial dysfunction, and several mediators of inflammation are up-regulated in subjects with atherosclerotic disease. Healthy, intact endothelium exhibits an antithrombotic, protective surface between the vascular lumen and vascular smooth muscle cells in the vessel wall. Oxidative stress is an imbalance between anti- and prooxidants, with a subsequent increase of reactive oxygen species, leading to tissue damage. The renin-angiotensin-aldosterone system is of vital importance in the pathobiology of vascular disease. Convincing data indicate that angiotensin II accelerates hypertension and augments the production of reactive oxygen species. This leads to the generation of a proinflammatory phenotype in human endothelial and vascular smooth muscle cells by the up-regulation of adhesion molecules, chemokines and cytokines. In addition, angiotensin II also seems to increase thrombin generation, possibly via a direct impact on tissue factor. However, the mechanism of cross-talk between inflammation and haemostasis can also contribute to prothrombotic states in inflammatory environments. Thus, blocking of the renin-angiotensin-aldosterone system might be an approach to reduce both inflammatory and thrombotic complications in high-risk patients. During COVID-19, the renin-angiotensin-aldosterone system may be activated. The levels of angiotensin II could contribute to the ongoing inflammation, which might result in a cytokine storm, a complication that significantly impairs prognosis. At the outbreak of COVID-19 concerns were raised about the use of angiotensin converting enzyme inhibitors and angiotensin receptor blocker drugs in patients with COVID-19 and hypertension or other cardiovascular comorbidities. However, the present evidence is in favor of continuing to use of these drugs. Based on experimental evidence, blocking the renin-angiotensin-aldosterone system might even exert a potentially protective influence in the setting of COVID-19.", "doi": "10.3389/fphar.2021.640185", "pmid": "34220496", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "640185"}, {"db": "pmc", "key": "PMC8245685"}], "notes": [], "created": "2021-07-06T05:41:56.778Z", "modified": "2021-08-06T08:53:09.932Z"}, {"entity": "publication", "iuid": "4c9b64be8bb24857b13e370d1b34c219", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4c9b64be8bb24857b13e370d1b34c219.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4c9b64be8bb24857b13e370d1b34c219"}}, "title": "Sphingolipids as Modulators of SARS-CoV-2 Infection.", "authors": [{"family": "T\u00f6rnquist", "given": "Kid", "initials": "K"}, {"family": "Asghar", "given": "Muhammad Yasir", "initials": "MY"}, {"family": "Srinivasan", "given": "Vignesh", "initials": "V"}, {"family": "Korhonen", "given": "Laura", "initials": "L"}, {"family": "Lindholm", "given": "Dan", "initials": "D"}], "type": "journal article", "published": "2021-06-17", "journal": {"title": "Front Cell Dev Biol", "issn": "2296-634X", "volume": "9", "pages": "689854", "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic with severe consequences for afflicted individuals and the society as a whole. The biology and infectivity of the virus has been intensively studied in order to gain a better understanding of the molecular basis of virus-host cell interactions during infection. It is known that SARS-CoV-2 binds to angiotensin-converting enzyme 2 (ACE2) via its spike protein. Priming of the virus by specific proteases leads to viral entry via endocytosis and to the subsequent steps in the life cycle of SARS-CoV-2. Sphingosine and ceramide belong to the sphingolipid family and are abundantly present in cell membranes. These lipids were recently shown to interfere with the uptake of virus particles of SARS-CoV-2 into epithelial cell lines and primary human nasal cells in culture. The mechanisms of action were partly different, as sphingosine blocked, whilst ceramide facilitated viral entry. Acid sphingomyelinase (ASM) is vital for the generation of ceramide and functional inhibition of ASM by drugs like amitriptyline reduced SARS-CoV-2 entry into the epithelial cells. Recent data indicates that serum level of sphingosine-1-phosphate (S1P) is a prognostic factor for COVID-2 severity. Further, stimulation of sphingosine-1-phosphate receptor 1 (S1PR1) might also constrain the hyper-inflammatory conditions linked to SARS-CoV-2. Here, we review recent exciting findings regarding sphingolipids in the uptake of SARS-CoV-2 and in the course of COVID-19 disease. More studies are required on the mechanisms of action and the potential use of antidepressant drugs and sphingolipid modifiers in SARS-CoV-2 infections and in the treatment of the more serious and fatal consequences of the disease.", "doi": "10.3389/fcell.2021.689854", "pmid": "34222257", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8245774"}], "notes": [], "created": "2021-07-06T05:41:28.669Z", "modified": "2021-08-06T08:48:14.607Z"}, {"entity": "publication", "iuid": "8b2f9bd35e10430bb600b4d2574b92bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b2f9bd35e10430bb600b4d2574b92bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b2f9bd35e10430bb600b4d2574b92bd"}}, "title": "Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2.", "authors": [{"family": "Roxhed", "given": "Niclas", "initials": "N", "orcid": "0000-0002-7147-6730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cda793d04e544bbcb7adbd7a8f3de217.json"}}, {"family": "Bendes", "given": "Annika", "initials": "A", "orcid": "0000-0001-9329-2353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87d0283c178b4aaeb0c3f1ad9187de7b.json"}}, {"family": "Dale", "given": "Matilda", "initials": "M", "orcid": "0000-0002-5788-7744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fbf8052f5b8449fabd27adb8316b973.json"}}, {"family": "Mattsson", "given": "Cecilia", "initials": "C"}, {"family": "Hanke", "given": "Leo", "initials": "L", "orcid": "0000-0001-5514-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a35f10de4f2e4aee98278f6ab845613d.json"}}, {"family": "Dodig-Crnkovi\u0107", "given": "Tea", "initials": "T", "orcid": "0000-0002-2875-896X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/63ccd5c5d27e4c11bd60a689e9d4a571.json"}}, {"family": "Christian", "given": "Murray", "initials": "M"}, {"family": "Meineke", "given": "Birthe", "initials": "B"}, {"family": "Els\u00e4sser", "given": "Simon", "initials": "S", "orcid": "0000-0001-8724-4849", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5521b3e3c4fa4e1c8eb4e19a079971a8.json"}}, {"family": "Andr\u00e9ll", "given": "Juni", "initials": "J"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1345-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a53a433db6f04a458e3d420f0c9995c5.json"}}, {"family": "Eklund", "given": "Carina", "initials": "C"}, {"family": "Dillner", "given": "Joakim", "initials": "J", "orcid": "0000-0001-8588-6506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bbb8b0ca5dc648e0b80c1de224b26c69.json"}}, {"family": "Beck", "given": "Olof", "initials": "O"}, {"family": "Thomas", "given": "Cecilia E", "initials": "CE", "orcid": "0000-0001-6201-6380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d34036550b84e67ae3185c65a857c95.json"}}, {"family": "McInerney", "given": "Gerald", "initials": "G", "orcid": "0000-0003-2257-7241", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7770437d845444a8a07865bf5b62fab0.json"}}, {"family": "Hong", "given": "Mun-Gwan", "initials": "MG", "orcid": "0000-0001-8603-8293", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fa0aa1a11e4d2ca5356a8a708536b2.json"}}, {"family": "Murrell", "given": "Ben", "initials": "B", "orcid": "0000-0002-0393-4445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60dac9ecf84d4eb3b90fb4ee1298bc52.json"}}, {"family": "Fredolini", "given": "Claudia", "initials": "C", "orcid": "0000-0002-7674-2014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/680bda0d693149f28ac18dff239101a8.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67a59fa5de37434c8b7151039c192a37.json"}}], "type": "journal article", "published": "2021-06-17", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "3695"}, "abstract": "Serological testing is essential to curb the consequences of the COVID-19 pandemic. However, most assays are still limited to single analytes and samples collected within healthcare. Thus, we establish a multianalyte and multiplexed approach to reliably profile IgG and IgM levels against several versions of SARS-CoV-2 proteins (S, RBD, N) in home-sampled dried blood spots (DBS). We analyse DBS collected during spring of 2020 from 878 random and undiagnosed individuals from the population in Stockholm, Sweden, and use classification approaches to estimate an accumulated seroprevalence of 12.5% (95% CI: 10.3%-14.7%). This includes 5.4% of the samples being IgG+IgM+ against several SARS-CoV-2 proteins, as well as 2.1% being IgG-IgM+ and 5.0% being IgG+IgM- for the virus' S protein. Subjects classified as IgG+ for several SARS-CoV-2 proteins report influenza-like symptoms more frequently than those being IgG+ for only the S protein (OR = 6.1; p < 0.001). Among all seropositive cases, 30% are asymptomatic. Our strategy enables an accurate individual-level and multiplexed assessment of antibodies in home-sampled blood, assisting our understanding about the undiagnosed seroprevalence and diversity of the immune response against the coronavirus.", "doi": "10.1038/s41467-021-23893-4", "pmid": "34140485", "labels": {"Funder: H2020": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Serology": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Host cell systems biology and targets": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8211676"}, {"db": "pii", "key": "10.1038/s41467-021-23893-4"}], "notes": [], "created": "2021-06-18T08:23:45.977Z", "modified": "2023-06-19T14:19:51.535Z"}, {"entity": "publication", "iuid": "0c407443885c4bbe84294a5ea15a53c7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c407443885c4bbe84294a5ea15a53c7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c407443885c4bbe84294a5ea15a53c7"}}, "title": "Extracorporeal membrane oxygenation for COVID-19 during first and second waves.", "authors": [{"family": "Broman", "given": "Lars Mikael", "initials": "LM"}, {"family": "Eksborg", "given": "Staffan", "initials": "S"}, {"family": "Coco", "given": "Valeria Lo", "initials": "VL"}, {"family": "De Piero", "given": "Maria Elena", "initials": "ME"}, {"family": "Belohlavek", "given": "Jan", "initials": "J"}, {"family": "Lorusso", "given": "Roberto", "initials": "R"}, {"family": "EuroECMO COVID-19 Working Group", "given": "", "initials": ""}, {"family": "Euro-ELSO Steering Committee", "given": "", "initials": ""}], "type": "letter", "published": "2021-06-16", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "issn-l": "2213-2600"}, "abstract": null, "doi": "10.1016/S2213-2600(21)00262-9", "pmid": "34146489", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(21)00262-9"}], "notes": [], "created": "2021-06-28T18:28:29.820Z", "modified": "2021-06-28T18:28:29.830Z"}, {"entity": "publication", "iuid": "784a4f6aae174440bf672e8ddc642b24", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/784a4f6aae174440bf672e8ddc642b24.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/784a4f6aae174440bf672e8ddc642b24"}}, "title": "Correction to: Risk of stress/depression and functional impairment in Denmark immediately following a COVID-19 shutdown.", "authors": [{"family": "Andersen", "given": "Lars H", "initials": "LH"}, {"family": "Fallesen", "given": "Peter", "initials": "P"}, {"family": "Bruckner", "given": "Tim A", "initials": "TA"}], "type": "published erratum", "published": "2021-06-16", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "21", "issue": "1", "pages": "1155", "issn-l": null}, "abstract": null, "doi": "10.1186/s12889-021-11204-x", "pmid": "34134702", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11204-x"}, {"db": "pmc", "key": "PMC8206909"}], "notes": [], "created": "2021-06-28T18:42:42.794Z", "modified": "2021-06-28T18:42:42.806Z"}, {"entity": "publication", "iuid": "60d0dac7396d423d8a6e2ada45422709", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60d0dac7396d423d8a6e2ada45422709.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60d0dac7396d423d8a6e2ada45422709"}}, "title": "COVID-19 and Delayed Cerebral Ischemia-More in Common Than First Meets the Eye.", "authors": [{"family": "Bhogal", "given": "Pervinder", "initials": "P"}, {"family": "Makalanda", "given": "Levansri", "initials": "L", "orcid": "0000-0001-6637-9293", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e57d3cb6d01c4a3d96234e31e2f471a1.json"}}, {"family": "Hassan", "given": "Ameer E", "initials": "AE", "orcid": "0000-0002-7148-7616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f5948193707428eac79c94a082dc3a9.json"}}, {"family": "Fiorella", "given": "Dave", "initials": "D"}, {"family": "Andersson", "given": "Tommy", "initials": "T", "orcid": "0000-0001-8202-7829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec80cd01fb984f2c927728d554f3d220.json"}}, {"family": "Ahmad", "given": "Muhammad", "initials": "M"}, {"family": "B\u00e4zner", "given": "Hansj\u00f6rg", "initials": "H"}, {"family": "Jaffer", "given": "Ounali", "initials": "O"}, {"family": "Henkes", "given": "Hans", "initials": "H", "orcid": "0000-0002-6534-036X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a14520c05674ca4aba1925525002829.json"}}], "type": "journal article", "published": "2021-06-16", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "10", "issue": "12", "issn-l": "2077-0383"}, "abstract": "Since the arrival of the global COVID-19 pandemic scientists around the world have been working to understand the pathological mechanisms resulting from infection. There has gradually been an understanding that COVID-19 triggers a widespread endotheliopathy and that this can result in a widespread thrombosis and in particular a microthrombosis. The mechanisms involved in the microthrombosis are not confined to infection and there is evidence that patients with aneurysmal sub-arachnoid haemorrhage (SAH) also suffer from an endotheliopathy and microthrombosis. In this article we attempt to shed light on similarities in the underlying processes involved in both diseases and suggest potential treatment options.", "doi": "10.3390/jcm10122646", "pmid": "34208470", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jcm10122646"}], "notes": [], "created": "2021-07-05T14:44:28.293Z", "modified": "2021-07-05T14:56:22.840Z"}, {"entity": "publication", "iuid": "875647dd80d9464088d6306cf0bccf64", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/875647dd80d9464088d6306cf0bccf64.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/875647dd80d9464088d6306cf0bccf64"}}, "title": "A novel automated SARS-CoV-2 saliva PCR test protects a global asymptomatic workforce.", "authors": [{"family": "Carter", "given": "Nikki", "initials": "N"}, {"family": "Clausen", "given": "Maryam", "initials": "M"}, {"family": "Halpin", "given": "Rebecca A", "initials": "RA"}, {"family": "Blackmore", "given": "Colin", "initials": "C"}, {"family": "Cai", "given": "Kang", "initials": "K"}, {"family": "Delpuech", "given": "Oona", "initials": "O"}, {"family": "Kohlmann", "given": "Alexander", "initials": "A"}, {"family": "Magnusson", "given": "Otto", "initials": "O"}, {"family": "March", "given": "Ruth", "initials": "R"}, {"family": "O'Neill", "given": "Daniel", "initials": "D"}, {"family": "Prakash", "given": "Kasthuri", "initials": "K"}, {"family": "Sherwood", "given": "James", "initials": "J"}, {"family": "Sundin", "given": "Tabetha", "initials": "T"}, {"family": "Swift", "given": "Jason", "initials": "J"}, {"family": "Tarakameh", "given": "Azar", "initials": "A"}, {"family": "Wijdicks", "given": "Marilou", "initials": "M"}, {"family": "Wise", "given": "Daniel", "initials": "D"}, {"family": "Fidock", "given": "Mark", "initials": "M"}], "type": "journal article", "published": "2021-06-16", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "12676"}, "abstract": "Regular PCR testing of nasopharyngeal swabs from symptomatic individuals for SARS-CoV-2 virus has become the established method by which health services are managing the COVID-19 pandemic. Businesses such as AstraZeneca have also prioritised voluntary asymptomatic testing to keep workplaces safe and maintain supply of essential medicines to patients. We describe the development of an internal automated SARS-CoV-2 testing programme including the transformative introduction of saliva as an alternative sample type.", "doi": "10.1038/s41598-021-92070-w", "pmid": "34135391", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-92070-w"}, {"db": "pmc", "key": "PMC8209156"}], "notes": [], "created": "2021-06-28T18:42:21.621Z", "modified": "2021-06-30T05:10:06.409Z"}, {"entity": "publication", "iuid": "3964c56151144b969fd3dbc05ed3069c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3964c56151144b969fd3dbc05ed3069c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3964c56151144b969fd3dbc05ed3069c"}}, "title": "SARS-CoV-2 Spike protein binding of glycated serum albumin - its potential role in the pathogenesis of the COVID-19 clinical syndromes and bias towards individuals with pre-diabetes/type 2 diabetes &amp; metabolic diseases", "authors": [{"family": "IIes", "given": "Jason K", "initials": "JK"}, {"family": "Zmuidinaite", "given": "Raminta", "initials": "R", "orcid": "0000-0001-7728-6623", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/421ae7d6575445888ac6bb7f537b4b16.json"}}, {"family": "Sadee", "given": "Christoph", "initials": "C"}, {"family": "Gardiner", "given": "Anna", "initials": "A"}, {"family": "Lacey", "given": "Jonathan", "initials": "J"}, {"family": "Harding", "given": "Stephen", "initials": "S"}, {"family": "Ule", "given": "Jernej", "initials": "J", "orcid": "0000-0002-2452-4277", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df39ffa7b830405ba54b42987ad9c0cc.json"}}, {"family": "Roblett", "given": "Debra", "initials": "D"}, {"family": "Iles", "given": "Ray K", "initials": "RK", "orcid": "0000-0003-0573-9739", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b815fcd924e64abcaa064fc3482f114f.json"}}], "type": "posted-content", "published": "2021-06-15", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.06.14.21258871", "pmid": null, "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-06-17T07:50:07.080Z", "modified": "2023-06-19T14:18:51.180Z"}, {"entity": "publication", "iuid": "3cedafdf25154a119a7554bb9b330128", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3cedafdf25154a119a7554bb9b330128.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3cedafdf25154a119a7554bb9b330128"}}, "title": "Public acceptance of COVID-19 vaccines: cross-national evidence on levels and individual-level predictors using observational data.", "authors": [{"family": "Lindholt", "given": "Marie Fly", "initials": "MF", "orcid": "0000-0002-8044-2559", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5117f1c9ca11402387d5d5994c8e358a.json"}}, {"family": "J\u00f8rgensen", "given": "Frederik", "initials": "F"}, {"family": "Bor", "given": "Alexander", "initials": "A"}, {"family": "Petersen", "given": "Michael Bang", "initials": "MB"}], "type": "journal article", "published": "2021-06-15", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "6", "pages": "e048172"}, "abstract": "The management of the COVID-19 pandemic hinges on the approval of safe and effective vaccines but, equally importantly, on high vaccine acceptance among people. To facilitate vaccine acceptance via effective health communication, it is key to understand levels of vaccine scepticism and the demographic, psychological and political predictors. To this end, we examine the levels and predictors of acceptance of an approved COVID-19 vaccine.\n\nWe examine the levels and predictors of acceptance of an approved COVID-19 vaccine in large online surveys from eight Western democracies that differ in terms of the severity of the pandemic and their response: Denmark, France, Germany, Hungary, Sweden, Italy, UK and USA (total N=18 231). Survey respondents were quota sampled to match the population margins on age, gender and geographical location for each country. The study was conducted from September 2020 to February 2021, allowing us to assess changes in acceptance and predictors as COVID-19 vaccine programmes were rolled out.\n\nThe outcome of the study is self-reported acceptance of a COVID-19 vaccine approved and recommended by health authorities.\n\nThe data reveal large variations in vaccine acceptance that ranges from 83% in Denmark to 47% in France and Hungary. Lack of vaccine acceptance is associated with lack of trust in authorities and scientists, conspiratorial thinking and a lack of concern about COVID-19.\n\nMost national levels of vaccine acceptance fall below estimates of the required threshold for herd immunity. The results emphasise the long-term importance of building trust in preparations for health emergencies such as the current pandemic. For health communication, the results emphasise the importance of focusing on personal consequences of infections and debunking of myths to guide communication strategies.", "doi": "10.1136/bmjopen-2020-048172", "pmid": "34130963", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8210695"}, {"db": "pii", "key": "bmjopen-2020-048172"}], "notes": [], "created": "2021-06-17T07:38:34.366Z", "modified": "2023-06-19T15:02:47.895Z"}, {"entity": "publication", "iuid": "a41604e113284f04ad764896bff28508", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a41604e113284f04ad764896bff28508.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a41604e113284f04ad764896bff28508"}}, "title": "Point of care detection of COVID-19: Advancement in biosensing and diagnostic methods.", "authors": [{"family": "Suleman", "given": "Shariq", "initials": "S"}, {"family": "Shukla", "given": "Sudheesh K", "initials": "SK"}, {"family": "Malhotra", "given": "Nitesh", "initials": "N"}, {"family": "Bukkitgar", "given": "Shikandar D", "initials": "SD"}, {"family": "Shetti", "given": "Nagaraj P", "initials": "NP"}, {"family": "Pilloton", "given": "Roberto", "initials": "R"}, {"family": "Narang", "given": "Jagriti", "initials": "J"}, {"family": "Nee Tan", "given": "Yen", "initials": "Y"}, {"family": "Aminabhavi", "given": "Tejraj M", "initials": "TM"}], "type": "journal article", "published": "2021-06-15", "journal": {"title": "Chem Eng J", "issn": "1385-8947", "volume": "414", "issue": null, "pages": "128759", "issn-l": null}, "abstract": "The recent outbreak of COVID-19 has created much inconvenience and fear that the virus can seriously affect humans, causing health hazards and death. This pandemic has created much worry and as per the report by World Health Organization (WHO), more than 43 million individuals in 215 countries and territories were affected. People around the world are still struggling to overcome the problems associated with this pandemic. Of all the available methods, reverse-transcriptase polymerase chain reaction (RT-PCR) has been widely practiced for the pandemic detection even though several diagnostic tools are available having varying accuracy and sensitivity. The method offers many advantages making it a life-saving tool, but the method has the limitation of transporting to the nearest pathology lab, thus limiting its application in resource limited settings. This has a risen a crucial need for point-of-care devices for on-site detection. In this venture, biosensors have been used, since they can be applied immediately at the point-of-care. This review will discuss about the available diagnostic methods and biosensors for COVID-19 detection.", "doi": "10.1016/j.cej.2021.128759", "pmid": "33551668", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1385-8947(21)00356-9"}, {"db": "pmc", "key": "PMC7847737"}], "notes": [], "created": "2021-02-10T18:50:48.806Z", "modified": "2021-02-10T18:50:48.828Z"}, {"entity": "publication", "iuid": "b93533b9d7704873b5fafccdffc467be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b93533b9d7704873b5fafccdffc467be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b93533b9d7704873b5fafccdffc467be"}}, "title": "Molecular determinants of disease severity in urinary tract infection.", "authors": [{"family": "Ambite", "given": "Ines", "initials": "I", "orcid": "0000-0003-1470-671X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b32089f6f4634bca8d1aa25dab3f1f1f.json"}}, {"family": "Butler", "given": "Daniel", "initials": "D", "orcid": "0000-0002-6717-545X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/091753e4d1ee46adaae712172033c21e.json"}}, {"family": "Wan", "given": "Murphy Lam Yim", "initials": "MLY"}, {"family": "Rosenblad", "given": "Therese", "initials": "T"}, {"family": "Tran", "given": "Thi Hien", "initials": "TH"}, {"family": "Chao", "given": "Sing Ming", "initials": "SM"}, {"family": "Svanborg", "given": "Catharina", "initials": "C"}], "type": "journal article", "published": "2021-06-15", "journal": {"title": "Nat Rev Urol", "issn": "1759-4820", "issn-l": null}, "abstract": "The most common and lethal bacterial pathogens have co-evolved with the host. Pathogens are the aggressors, and the host immune system is responsible for the defence. However, immune responses can also become destructive, and excessive innate immune activation is a major cause of infection-associated morbidity, exemplified by symptomatic urinary tract infections (UTIs), which are caused, in part, by excessive innate immune activation. Severe kidney infections (acute pyelonephritis) are a major cause of morbidity and mortality, and painful infections of the urinary bladder (acute cystitis) can become debilitating in susceptible patients. Disease severity is controlled at specific innate immune checkpoints, and a detailed understanding of their functions is crucial for strategies to counter microbial aggression with novel treatment and prevention measures. One approach is the use of bacterial molecules that reprogramme the innate immune system, accelerating or inhibiting disease processes. A very different outcome is asymptomatic bacteriuria, defined by low host immune responsiveness to bacteria with attenuated virulence. This observation provides the rationale for immunomodulation as a new therapeutic tool to deliberately modify host susceptibility, control the host response and avoid severe disease. The power of innate immunity as an arbitrator of health and disease is also highly relevant for emerging pathogens, including the current COVID-19 pandemic.", "doi": "10.1038/s41585-021-00477-x", "pmid": "34131331", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41585-021-00477-x"}], "notes": [], "created": "2021-06-17T07:36:27.229Z", "modified": "2021-06-17T07:36:40.244Z"}, {"entity": "publication", "iuid": "725d7eea1cf94a2db46c13223e5682a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/725d7eea1cf94a2db46c13223e5682a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/725d7eea1cf94a2db46c13223e5682a2"}}, "title": "Changes to household income in a Kenyan informal settlement during COVID-19", "authors": [{"family": "Tompsett", "given": "Anna", "initials": "A", "orcid": "0000-0002-5415-6583", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/780bff9b7f844676884c466b184933d1.json"}}, {"family": "Baum", "given": "Aaron", "initials": "A", "orcid": "0000-0003-4999-3480", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9df82e2e71604e7fbd3d3a38280ee2e9.json"}}, {"family": "Bukachi", "given": "Vera", "initials": "V", "orcid": "0000-0003-0448-1983", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a5c57d3aedd49d69e028bbe47b8b2f7.json"}}, {"family": "Kipkemboi", "given": "Pascal", "initials": "P"}, {"family": "K\u2019oyoo", "given": "Allan Ouko", "initials": "AO"}, {"family": "Varela", "given": "Ana Varela", "initials": "AV", "orcid": "0000-0003-1960-5619", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3604aec1e9445d18b4be865638d6cb1.json"}}, {"family": "Mulligan", "given": "Joseph", "initials": "J", "orcid": "0000-0002-8614-3787", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c4c96ea8f904b52b0d099c912511547.json"}}], "type": "posted-content", "published": "2021-06-15", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.06.15.21254693", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-06-17T07:51:05.519Z", "modified": "2023-06-19T14:11:58.638Z"}, {"entity": "publication", "iuid": "d94670e1580f4e05bc5b84b85be4eba7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d94670e1580f4e05bc5b84b85be4eba7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d94670e1580f4e05bc5b84b85be4eba7"}}, "title": "SARS-CoV-2 antigen testing: weighing the false positives against the costs of failing to control transmission.", "authors": [{"family": "Fearon", "given": "Elizabeth", "initials": "E"}, {"family": "Buchan", "given": "Iain E", "initials": "IE"}, {"family": "Das", "given": "Rajenki", "initials": "R"}, {"family": "Davis", "given": "Emma L", "initials": "EL"}, {"family": "Fyles", "given": "Martyn", "initials": "M"}, {"family": "Hall", "given": "Ian", "initials": "I"}, {"family": "Hollingsworth", "given": "T Deirdre", "initials": "TD"}, {"family": "House", "given": "Thomas", "initials": "T"}, {"family": "Jay", "given": "Caroline", "initials": "C"}, {"family": "Medley", "given": "Graham F", "initials": "GF"}, {"family": "Pellis", "given": "Lorenzo", "initials": "L"}, {"family": "Quilty", "given": "Billy J", "initials": "BJ"}, {"family": "Silva", "given": "Miguel E P", "initials": "MEP"}, {"family": "Stage", "given": "Helena B", "initials": "HB"}, {"family": "Wingfield", "given": "Tom", "initials": "T"}], "type": "journal article", "published": "2021-06-14", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "issn-l": "2213-2600", "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/S2213-2600(21)00234-4", "pmid": "34139150", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Proteins": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(21)00234-4"}, {"db": "pmc", "key": "PMC8203180"}], "notes": [], "created": "2021-06-28T18:38:00.383Z", "modified": "2021-06-28T18:38:15.256Z"}, {"entity": "publication", "iuid": "83359ec64ced454083ee5d1daa70968e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/83359ec64ced454083ee5d1daa70968e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/83359ec64ced454083ee5d1daa70968e"}}, "title": "Quality of web-based information at the beginning of a global pandemic: a cross-sectional infodemiology study investigating preventive measures and self care methods of the coronavirus disease 2019.", "authors": [{"family": "Stern", "given": "Jenny", "initials": "J"}, {"family": "Georgsson", "given": "Susanne", "initials": "S"}, {"family": "Carlsson", "given": "Tommy", "initials": "T"}], "type": "journal article", "published": "2021-06-14", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "1141"}, "abstract": "reducing the spread and impact epidemics and pandemics requires that members of the general population change their behaviors according to the recommendations, restrictions and laws provided by leading authorities. When a new epidemic or pandemic emerges, people are faced with the challenge of sorting through a great volume of varied information. Therefore, the dissemination of high-quality web-based information is essential during this time period. The overarching aim was to investigate the quality of web-based information about preventive measures and self care methods at the beginning of the COVID-19 pandemic.\r\n\r\nin May 2020, consumer-oriented websites written in Swedish were identified via systematic searches in Google (n = 76). Websites were assessed with inductive content analysis, the JAMA benchmarks, the QUEST tool and the DISCERN instrument.\r\n\r\nseven categories and 33 subcategories were identified concerning preventive measures (md = 6.0 subcategories), with few specifying a method for washing hands (n = 4), when to sanitize the hands (n = 4), and a method for sanitizing the hands (n = 1). Eight categories and 30 subcategories were identified concerning self care methods (md = 3.0 subcategories), with few referring to the national number for telephone-based counseling (n = 20) and an online symptom assessment tool (n = 16). Overall, the median total quality scores were low (JAMA = 0/4, QUEST =13/28, DISCERN = 29/80).\r\n\r\nat the beginning of the pandemic, substantial quality deficits of websites about COVID-19 may have counteracted the public recommendations for preventive measures. This illustrates a critical need for standardized and systematic routines on how to achieve dissemination of high-quality web-based information when new epidemics and pandemics emerge.", "doi": "10.1186/s12889-021-11141-9", "pmid": "34126962", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11141-9"}], "notes": [], "created": "2021-06-17T07:45:13.842Z", "modified": "2021-07-14T10:43:17.935Z"}, {"entity": "publication", "iuid": "6a76f804003d4811a92d215d7bebb1d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a76f804003d4811a92d215d7bebb1d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a76f804003d4811a92d215d7bebb1d7"}}, "title": "Internet-Based Cognitive Behavioral Therapy for Psychological Distress Associated With the COVID-19 Pandemic: A Pilot Randomized Controlled Trial.", "authors": [{"family": "Aminoff", "given": "Victoria", "initials": "V"}, {"family": "Sell\u00e9n", "given": "Malin", "initials": "M"}, {"family": "S\u00f6rliden", "given": "Elise", "initials": "E"}, {"family": "Ludvigsson", "given": "Mikael", "initials": "M"}, {"family": "Berg", "given": "Matilda", "initials": "M"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}], "type": "journal article", "published": "2021-06-14", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "684540", "issn-l": "1664-1078"}, "abstract": "Background: The COVID-19 pandemic has been associated with various negative psychological consequences. This is a challenge for the society as regular psychological services cannot be offered to the same extent as before the pandemic. In addition to the requirement of social distancing, there is a need to adjust psychological treatment components like exposure to avoid increasing the spread of the infection. Internet-delivered cognitive behavior therapy (ICBT) has an established evidence base for a range of psychiatric problems and has been suggested as one possible approach to deal with the situation. This study aimed to conduct a randomized controlled pilot trial during the summer of 2020 with a broad focus on psychological distress and a treatment approach that tailors the intervention based on symptom profile and preferences. Methods: Following the advertisement and interview, we included 52 participants with elevated levels of psychological distress. They were randomly allocated to either a 7-week-long individually tailored ICBT (n = 26) or a wait-list control condition (n = 26). Measures of depression and quality of life were used as primary outcomes. We also included secondary outcome measures of anxiety, insomnia, trauma, stress, anger, and alcohol use. For screening, we used the CoRonavIruS Health Impact Survey (CRISIS). Results: Overall moderate to large between-group effects were found at post-treatment in favor of the treatment on measures of both depression [Beck Depression Inventory (BDI); Cohens d = 0.63; Patient Health Questionnaire (PHQ-9): d = 0.62] and anxiety [Generalized Anxiety Disorder-7-item scale (GAD-7); d = 0.82]. This was also observed for stress symptoms [Perceived Stress Scale (PSS-14); d = 1.04]. No effects were seen on measures of quality of life, insomnia, symptoms of post-traumatic stress, and anger. There was an effect on alcohol use [Alcohol Use Disorder Identification Test (AUDIT); d = 0.54], which was not of clinical relevance. Conclusion: Individually tailored ICBT shows initial promise as a way to reduce psychological problems in association with the COVID-19 pandemic. A possible limitation was that the trial was conducted when the effects of the pandemic were decreasing and when fewer people were affected by the restrictions (e.g., the summer of 2020).", "doi": "10.3389/fpsyg.2021.684540", "pmid": "34194374", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8236879"}], "notes": [], "created": "2021-07-05T14:30:27.245Z", "modified": "2021-07-05T14:30:27.258Z"}, {"entity": "publication", "iuid": "66daaaac6fb74d54bbdeb2514441f642", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66daaaac6fb74d54bbdeb2514441f642.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66daaaac6fb74d54bbdeb2514441f642"}}, "title": "Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19: the PROFLO multicenter randomized clinical trial.", "authors": [{"family": "Ros\u00e9n", "given": "Jacob", "initials": "J", "orcid": "0000-0001-9518-5834", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ce3d5b2cb914d72bbd476b7e1127c8d.json"}}, {"family": "von Oelreich", "given": "Erik", "initials": "E"}, {"family": "Fors", "given": "Diddi", "initials": "D"}, {"family": "Jonsson Fagerlund", "given": "Malin", "initials": "M"}, {"family": "Taxbro", "given": "Knut", "initials": "K"}, {"family": "Skorup", "given": "Paul", "initials": "P"}, {"family": "Eby", "given": "Ludvig", "initials": "L"}, {"family": "Campoccia Jalde", "given": "Francesca", "initials": "F"}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Bergstr\u00f6m", "given": "Gustav", "initials": "G"}, {"family": "Frykholm", "given": "Peter", "initials": "P"}, {"family": "PROFLO Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-06-14", "journal": {"title": "Crit Care", "issn": "1466-609X", "volume": "25", "issue": "1", "pages": "209", "issn-l": "1364-8535"}, "abstract": "The effect of awake prone positioning on intubation rates is not established. The aim of this trial was to investigate if a protocol for awake prone positioning reduces the rate of endotracheal intubation compared with standard care among patients with moderate to severe hypoxemic respiratory failure due to COVID-19.\n\nWe conducted a multicenter randomized clinical trial. Adult patients with confirmed COVID-19, high-flow nasal oxygen or noninvasive ventilation for respiratory support and a PaO 2/FiO2 ratio \u2264 20 kPa were randomly assigned to a protocol targeting 16 h prone positioning per day or standard care. The primary endpoint was intubation within 30 days. Secondary endpoints included duration of awake prone positioning, 30-day mortality, ventilator-free days, hospital and intensive care unit length of stay, use of noninvasive ventilation, organ support and adverse events. The trial was terminated early due to futility.\n\nOf 141 patients assessed for eligibility, 75 were randomized of whom 39 were allocated to the control group and 36 to the prone group. Within 30 days after enrollment, 13 patients (33%) were intubated in the control group versus 12 patients (33%) in the prone group (HR 1.01 (95% CI 0.46-2.21), P = 0.99). Median prone duration was 3.4 h [IQR 1.8-8.4] in the control group compared with 9.0 h per day [IQR 4.4-10.6] in the prone group (P = 0.014). Nine patients (23%) in the control group had pressure sores compared with two patients (6%) in the prone group (difference - 18% (95% CI - 2 to - 33%); P = 0.032). There were no other differences in secondary outcomes between groups.\n\nThe implemented protocol for awake prone positioning increased duration of prone positioning, but did not reduce the rate of intubation in patients with hypoxemic respiratory failure due to COVID-19 compared to standard care.\n\nISRCTN54917435. Registered 15 June 2020 ( https://doi.org/10.1186/ISRCTN54917435 ).", "doi": "10.1186/s13054-021-03602-9", "pmid": "34127046", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-021-03602-9"}], "notes": [], "created": "2021-06-17T07:46:39.730Z", "modified": "2021-06-17T07:46:39.756Z"}, {"entity": "publication", "iuid": "fd6568a926674a8cb267ba9af3f57b03", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fd6568a926674a8cb267ba9af3f57b03.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fd6568a926674a8cb267ba9af3f57b03"}}, "title": "A time-resolved proteomic and prognostic map of COVID-19.", "authors": [{"family": "Demichev", "given": "Vadim", "initials": "V"}, {"family": "Tober-Lau", "given": "Pinkus", "initials": "P"}, {"family": "Lemke", "given": "Oliver", "initials": "O"}, {"family": "Nazarenko", "given": "Tatiana", "initials": "T"}, {"family": "Thibeault", "given": "Charlotte", "initials": "C"}, {"family": "Whitwell", "given": "Harry", "initials": "H"}, {"family": "R\u00f6hl", "given": "Annika", "initials": "A"}, {"family": "Freiwald", "given": "Anja", "initials": "A"}, {"family": "Szyrwiel", "given": "Lukasz", "initials": "L"}, {"family": "Ludwig", "given": "Daniela", "initials": "D"}, {"family": "Correia-Melo", "given": "Clara", "initials": "C"}, {"family": "Aulakh", "given": "Simran Kaur", "initials": "SK"}, {"family": "Helbig", "given": "Elisa T", "initials": "ET"}, {"family": "Stubbemann", "given": "Paula", "initials": "P"}, {"family": "Lippert", "given": "Lena J", "initials": "LJ"}, {"family": "Gr\u00fcning", "given": "Nana-Maria", "initials": "N"}, {"family": "Blyuss", "given": "Oleg", "initials": "O"}, {"family": "Vernardis", "given": "Spyros", "initials": "S"}, {"family": "White", "given": "Matthew", "initials": "M"}, {"family": "Messner", "given": "Christoph B", "initials": "CB"}, {"family": "Joannidis", "given": "Michael", "initials": "M"}, {"family": "Sonnweber", "given": "Thomas", "initials": "T"}, {"family": "Klein", "given": "Sebastian J", "initials": "SJ"}, {"family": "Pizzini", "given": "Alex", "initials": "A"}, {"family": "Wohlfarter", "given": "Yvonne", "initials": "Y"}, {"family": "Sahanic", "given": "Sabina", "initials": "S"}, {"family": "Hilbe", "given": "Richard", "initials": "R"}, {"family": "Schaefer", "given": "Benedikt", "initials": "B"}, {"family": "Wagner", "given": "Sonja", "initials": "S"}, {"family": "Mittermaier", "given": "Mirja", "initials": "M"}, {"family": "Machleidt", "given": "Felix", "initials": "F"}, {"family": "Garcia", "given": "Carmen", "initials": "C"}, {"family": "Ruwwe-Gl\u00f6senkamp", "given": "Christoph", "initials": "C"}, {"family": "Lingscheid", "given": "Tilman", "initials": "T"}, {"family": "Bosquillon de Jarcy", "given": "Laure", "initials": "L"}, {"family": "Stegemann", "given": "Miriam S", "initials": "MS"}, {"family": "Pfeiffer", "given": "Moritz", "initials": "M"}, {"family": "J\u00fcrgens", "given": "Linda", "initials": "L"}, {"family": "Denker", "given": "Sophy", "initials": "S"}, {"family": "Zickler", "given": "Daniel", "initials": "D"}, {"family": "Enghard", "given": "Philipp", "initials": "P"}, {"family": "Zelezniak", "given": "Aleksej", "initials": "A"}, {"family": "Campbell", "given": "Archie", "initials": "A"}, {"family": "Hayward", "given": "Caroline", "initials": "C"}, {"family": "Porteous", "given": "David J", "initials": "DJ"}, {"family": "Marioni", "given": "Riccardo E", "initials": "RE"}, {"family": "Uhrig", "given": "Alexander", "initials": "A"}, {"family": "M\u00fcller-Redetzky", "given": "Holger", "initials": "H"}, {"family": "Zoller", "given": "Heinz", "initials": "H"}, {"family": "L\u00f6ffler-Ragg", "given": "Judith", "initials": "J"}, {"family": "Keller", "given": "Markus A", "initials": "MA"}, {"family": "Tancevski", "given": "Ivan", "initials": "I"}, {"family": "Timms", "given": "John F", "initials": "JF"}, {"family": "Zaikin", "given": "Alexey", "initials": "A"}, {"family": "Hippenstiel", "given": "Stefan", "initials": "S"}, {"family": "Ramharter", "given": "Michael", "initials": "M"}, {"family": "Witzenrath", "given": "Martin", "initials": "M"}, {"family": "Suttorp", "given": "Norbert", "initials": "N"}, {"family": "Lilley", "given": "Kathryn", "initials": "K"}, {"family": "M\u00fclleder", "given": "Michael", "initials": "M"}, {"family": "Sander", "given": "Leif Erik", "initials": "LE"}, {"family": "PA-COVID-19 Study group", "given": "", "initials": ""}, {"family": "Ralser", "given": "Markus", "initials": "M"}, {"family": "Kurth", "given": "Florian", "initials": "F"}], "type": "journal article", "published": "2021-06-14", "journal": {"title": "Cell Syst", "issn": "2405-4720", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. We characterized the time-dependent progression of the disease in 139 COVID-19 inpatients by measuring 86 accredited diagnostic parameters, such as blood cell counts and enzyme activities, as well as untargeted plasma proteomes at 687 sampling points. We report an initial spike in a systemic inflammatory response, which is gradually alleviated and followed by a protein signature indicative of tissue repair, metabolic reconstitution, and immunomodulation. We identify prognostic marker signatures for devising risk-adapted treatment strategies and use machine learning to classify therapeutic needs. We show that the machine learning models based on the proteome are transferable to an independent cohort. Our study presents a map linking routinely used clinical diagnostic parameters to plasma proteomes and their dynamics in an infectious disease.", "doi": "10.1016/j.cels.2021.05.005", "pmid": "34139154", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S2405-4712(21)00160-5"}, {"db": "pmc", "key": "PMC8201874"}], "notes": [], "created": "2021-06-28T18:35:54.366Z", "modified": "2021-06-30T05:12:43.763Z"}, {"entity": "publication", "iuid": "18f851e21f6d4ea4b5bd88550870048c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18f851e21f6d4ea4b5bd88550870048c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18f851e21f6d4ea4b5bd88550870048c"}}, "title": "SARS-CoV-2 spike protein removes lipids from model membranes and interferes with the capacity of high density lipoprotein to exchange lipids.", "authors": [{"family": "Correa", "given": "Yubexi", "initials": "Y"}, {"family": "Waldie", "given": "Sarah", "initials": "S"}, {"family": "Th\u00e9paut", "given": "Michel", "initials": "M"}, {"family": "Micciula", "given": "Samantha", "initials": "S"}, {"family": "Moulin", "given": "Martine", "initials": "M"}, {"family": "Fieschi", "given": "Franck", "initials": "F"}, {"family": "Pichler", "given": "Harald", "initials": "H"}, {"family": "Trevor Forsyth", "given": "V", "initials": "V"}, {"family": "Haertlein", "given": "Michael", "initials": "M"}, {"family": "C\u00e1rdenas", "given": "Marit\u00e9", "initials": "M"}], "type": "journal article", "published": "2021-06-12", "journal": {"title": "J Colloid Interface Sci", "issn": "1095-7103", "issn-l": null, "volume": "602", "issue": null, "pages": "732-739"}, "abstract": "Cholesterol has been shown to affect the extent of coronavirus binding and fusion to cellular membranes. The severity of Covid-19 infection is also known to be correlated with lipid disorders. Furthermore, the levels of both serum cholesterol and high-density lipoprotein (HDL) decrease with Covid-19 severity, with normal levels resuming once the infection has passed. Here we demonstrate that the SARS-CoV-2 spike (S) protein interferes with the function of lipoproteins, and that this is dependent on cholesterol. In particular, the ability of HDL to exchange lipids from model cellular membranes is altered when co-incubated with the spike protein. Additionally, the S protein removes lipids and cholesterol from model membranes. We propose that the S protein affects HDL function by removing lipids from it and remodelling its composition/structure.", "doi": "10.1016/j.jcis.2021.06.056", "pmid": "34157514", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S0021-9797(21)00930-9"}, {"db": "pmc", "key": "PMC8195693"}], "notes": [], "created": "2021-06-28T18:20:09.531Z", "modified": "2021-06-28T18:21:11.283Z"}, {"entity": "publication", "iuid": "e88362b5f2fc485c865d6d25f77f54cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e88362b5f2fc485c865d6d25f77f54cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e88362b5f2fc485c865d6d25f77f54cc"}}, "title": "Decreased Mortality Over Time During the First Wave in Patients With COVID-19 in Geriatric Care: Data From the Stockholm GeroCovid Study.", "authors": [{"family": "Xu", "given": "Hong", "initials": "H"}, {"family": "Garcia-Ptacek", "given": "Sara", "initials": "S"}, {"family": "Annetorp", "given": "Martin", "initials": "M"}, {"family": "Cederholm", "given": "Tommy", "initials": "T"}, {"family": "Engel", "given": "Georg", "initials": "G"}, {"family": "Engstr\u00f6m", "given": "Malin", "initials": "M"}, {"family": "Erlandsson", "given": "H\u00e5kan", "initials": "H"}, {"family": "Julius", "given": "Charlotte", "initials": "C"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Lundberg", "given": "Lars G\u00f6ran", "initials": "LG"}, {"family": "Metzner", "given": "Carina", "initials": "C"}, {"family": "Sandberg", "given": "Linda", "initials": "L"}, {"family": "Nyvang", "given": "Josefina Skog\u00f6", "initials": "JS"}, {"family": "\u00d6berg", "given": "Carina S\u00fchl", "initials": "CS"}, {"family": "\u00c5kesson", "given": "Elisabet", "initials": "E"}, {"family": "Religa", "given": "Dorota", "initials": "D"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-06-12", "journal": {"title": "J Am Med Dir Assoc", "issn": "1538-9375", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To describe temporal changes in treatment, care, and short-term mortality outcomes of geriatric patients during the first wave of the COVID-19 pandemic.\r\n\r\nObservational study.\r\n\r\nAltogether 1785 patients diagnosed with COVID-19 and 6744 hospitalized for non-COVID-19 causes at 7 geriatric clinics in Stockholm from March 6 to July 31, 2020, were included.\r\n\r\nAcross admission month, patient vital signs and pharmacological treatment in relationship to risk for in-hospital death were analyzed using the Poisson regression model. Incidence rates (IRs) and incidence rate ratios (IRRs) of death are presented.\r\n\r\nIn patients with COVID-19, the IR of mortality were 27%, 17%, 10%, 8%, and 2% from March to July, respectively, after standardization for demographics and vital signs. Compared with patients admitted in March, the risk of in-hospital death decreased by 29% [IRR 0.71, 95% confidence interval (CI) 0.51-0.99] in April, 61% (0.39, 0.26-0.58) in May, 68% (0.32, 0.19-0.55) in June, and 86% (0.14, 0.03-0.58) in July. The proportion of patients admitted for geriatric care with oxygen saturation <90% decreased from 13% to 1%, which partly explains the improvement of COVID-19 patient survival. In non-COVID-19 patients during the pandemic, mortality rates remained relatively stable (IR 1.3%-2.3%). Compared with non-COVID-19 geriatric patients, the IRR of death declined from 11 times higher (IRR 11.7, 95% CI 6.11-22.3) to 1.6 times (2.61, 0.50-13.7) between March and July in patients with COVID-19.\r\n\r\nMortality risk in geriatric patients from the Stockholm region declined over time throughout the first pandemic wave of COVID-19. The improved survival rate over time was only partly related to improvement in saturation status at the admission of the patients hospitalized later throughout the pandemic. Lower incidence during the later months could have led to less severe hospitalized cases driving down mortality.", "doi": "10.1016/j.jamda.2021.06.005", "pmid": "34216553", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1525-8610(21)00554-5"}], "notes": [], "created": "2021-07-05T15:02:15.808Z", "modified": "2021-07-14T10:42:45.179Z"}, {"entity": "publication", "iuid": "10fa73a458484d42bf0e15088c099fb3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/10fa73a458484d42bf0e15088c099fb3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/10fa73a458484d42bf0e15088c099fb3"}}, "title": "Consequences of visiting restrictions during the COVID-19 pandemic: An integrative review.", "authors": [{"family": "Hugelius", "given": "Karin", "initials": "K"}, {"family": "Harada", "given": "Nahoko", "initials": "N"}, {"family": "Marutani", "given": "Miki", "initials": "M"}], "type": "journal article", "published": "2021-06-12", "journal": {"title": "Int J Nurs Stud", "issn": "1873-491X", "volume": "121", "pages": "104000", "issn-l": null}, "abstract": "During the COVID-19 pandemic, visiting restrictions of different extents have been implemented. However, despite the long history of visiting restrictions in health care systems, little is known about their effects.\n\nThis review sought to explore the consequences of visitor restrictions in health care services during the COVID-19 pandemic.\n\nA systematic, integrative review was conducted in accordance with the PRISMA guidelines, based on a systematic search in PubMed, CHINAL full plus, Web of Science, PsychInfo, Scopus and the Cochrane Library.\n\nA total of 17 scientific papers covering intensive care, pediatric care, general medical care, hospital care, palliative care and nursing home settings were included. Although appreciation for the technical solutions enabling remote meetings was reported, visiting restrictions had several consequences, mainly negative, for the patient's health, the health and wellbeing of family members and the provision of care. Among physical health consequences, reduced nutrition intake, decreased activities of daily living and increased physical pain and symptoms were reported. Among mental health consequences for the patient, loneliness, depressive symptoms, agitation, aggression, reduced cognitive ability and overall dissatisfaction were observed. For family members, worry, anxiety and uncertainty occurred, and they reported an increased need for information from care providers. Family members of neonatal intensive care unit patients reported less bonding with their child and family relation disturbances due to the restrictions. For care providers, visiting restrictions added the burdens of ethical dilemmas, learning new technical means to enable social interaction and an increased demand for communication with families and providing social support to both family members and patients.\n\nWhen implementing visiting restrictions in health care services, decision makers and nurses need to be aware of their potential negative effects and adapt the provision of care to compensate for such effects. Nurses in all sectors should be aware that visiting restrictions may affect patients, families, and health care services for longer than the actual pandemic. Since the level of evidence regarding effect from visiting restrictions is low, further studies is strongly needed.", "doi": "10.1016/j.ijnurstu.2021.104000", "pmid": "34242976", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0020-7489(21)00147-4"}, {"db": "pmc", "key": "PMC8196532"}], "notes": [], "created": "2021-08-06T07:57:55.486Z", "modified": "2021-08-06T07:57:55.509Z"}, {"entity": "publication", "iuid": "a4b68701383d467f979b00c17c6ae119", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a4b68701383d467f979b00c17c6ae119.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a4b68701383d467f979b00c17c6ae119"}}, "title": "Profiling Human CMV-specific T cell responses reveals novel immunogenic ORFs", "authors": [{"family": "Dhanwani", "given": "Rekha", "initials": "R", "orcid": "0000-0002-6592-8657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d61c1971458d49e0888b29976e0a3893.json"}}, {"family": "Dhanda", "given": "Sandeep Kumar", "initials": "SK"}, {"family": "Pham", "given": "John", "initials": "J"}, {"family": "Williams", "given": "Gregory P", "initials": "GP"}, {"family": "Sidney", "given": "John", "initials": "J"}, {"family": "Grifoni", "given": "Alba", "initials": "A", "orcid": "0000-0002-2209-5966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2cbbaebec64e41289979d55aed0b0ad4.json"}}, {"family": "Picarda", "given": "Gaelle", "initials": "G"}, {"family": "Lindestam Arlehamn", "given": "Cecilia S", "initials": "CS"}, {"family": "Sette", "given": "Alessandro", "initials": "A"}, {"family": "Benedict", "given": "Chris A", "initials": "CA"}], "type": "posted-content", "published": "2021-06-11", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.06.10.447997", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-06-14T14:52:49.944Z", "modified": "2023-06-19T15:22:57.372Z"}, {"entity": "publication", "iuid": "bfa777673501494b873a86821c2f9a30", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bfa777673501494b873a86821c2f9a30.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bfa777673501494b873a86821c2f9a30"}}, "title": "Natural killer cells in antiviral immunity.", "authors": [{"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Strunz", "given": "Benedikt", "initials": "B"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}], "type": "journal article", "published": "2021-06-11", "journal": {"title": "Nat Rev Immunol", "issn": "1474-1741", "issn-l": "1474-1733", "volume": null, "issue": null, "pages": null}, "abstract": "Natural killer (NK) cells play an important role in innate immune responses to viral infections. Here, we review recent insights into the role of NK cells in viral infections, with particular emphasis on human studies. We first discuss NK cells in the context of acute viral infections, with flavivirus and influenza virus infections as examples. Questions related to activation of NK cells, homing to infected tissues and the role of tissue-resident NK cells in acute viral infections are also addressed. Next, we discuss NK cells in the context of chronic viral infections with hepatitis C virus and HIV-1. Also covered is the role of adaptive-like NK cell expansions as well as the appearance of CD56 - NK cells in the course of chronic infection. Specific emphasis is then placed in viral infections in patients with primary immunodeficiencies affecting NK cells. Not least, studies in this area have revealed an important role for NK cells in controlling several herpesvirus infections. Finally, we address new data with respect to the activation of NK cells and NK cell function in humans infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) giving rise to coronavirus disease 2019 (COVID-19).", "doi": "10.1038/s41577-021-00558-3", "pmid": "34117484", "labels": {"Type: Review": null, "Funder: H2020": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41577-021-00558-3"}], "notes": [], "created": "2021-06-14T06:31:09.794Z", "modified": "2021-06-14T06:32:50.189Z"}, {"entity": "publication", "iuid": "fa45de1635df45478ddcbcc3953153c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa45de1635df45478ddcbcc3953153c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa45de1635df45478ddcbcc3953153c5"}}, "title": "Mental Health of Refugees and Migrants during the COVID-19 Pandemic: The Role of Experienced Discrimination and Daily Stressors.", "authors": [{"family": "Spiritus-Beerden", "given": "Eva", "initials": "E", "orcid": "0000-0003-2312-8034", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/515f6b3d01664e988fefe0a5344ce7c9.json"}}, {"family": "Verelst", "given": "An", "initials": "A", "orcid": "0000-0002-7178-643X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbcb257027514818993b0318a7c513bf.json"}}, {"family": "Devlieger", "given": "Ines", "initials": "I"}, {"family": "Langer Primdahl", "given": "Nina", "initials": "N"}, {"family": "Botelho Guedes", "given": "F\u00e1bio", "initials": "F"}, {"family": "Chiarenza", "given": "Antonio", "initials": "A"}, {"family": "De Maesschalck", "given": "Stephanie", "initials": "S"}, {"family": "Durbeej", "given": "Natalie", "initials": "N"}, {"family": "Garrido", "given": "Roc\u00edo", "initials": "R", "orcid": "0000-0002-2238-0222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa02e7e75daf40c79c429493d506693b.json"}}, {"family": "Gaspar de Matos", "given": "Margarida", "initials": "M"}, {"family": "Ioannidi", "given": "Elisabeth", "initials": "E"}, {"family": "Murphy", "given": "Rebecca", "initials": "R"}, {"family": "Oulahal", "given": "Rachid", "initials": "R", "orcid": "0000-0002-9120-0512", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb7a43d0144541ad9598f666f28e0564.json"}}, {"family": "Osman", "given": "Fatumo", "initials": "F"}, {"family": "Padilla", "given": "Beatriz", "initials": "B"}, {"family": "Paloma", "given": "Virginia", "initials": "V", "orcid": "0000-0002-0707-1982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f9661fbebe54eb6971d4e2644d487cd.json"}}, {"family": "Shehadeh", "given": "Amer", "initials": "A"}, {"family": "Sturm", "given": "Gesine", "initials": "G"}, {"family": "van den Muijsenbergh", "given": "Maria", "initials": "M"}, {"family": "Vasilikou", "given": "Katerina", "initials": "K"}, {"family": "Watters", "given": "Charles", "initials": "C"}, {"family": "Willems", "given": "Sara", "initials": "S", "orcid": "0000-0002-6349-7785", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a066fe07ba24b948a9ad37dc2db7a8d.json"}}, {"family": "Skovdal", "given": "Morten", "initials": "M"}, {"family": "Derluyn", "given": "Ilse", "initials": "I"}], "type": "journal article", "published": "2021-06-11", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "12", "pages": "6354"}, "abstract": "The COVID-19 pandemic is a defining global health crisis of our time. While the impact of COVID-19, including its mental health impact, is increasingly being documented, there remain important gaps regarding the specific consequences of the pandemic on particular population groups, including refugees and migrants. This study aims to uncover the impact of the COVID-19 pandemic on the mental health of refugees and migrants worldwide, disentangling the possible role of social and daily stressors, i.e., experiences of discrimination and daily living conditions. Descriptive analysis and structural equation modeling were used to analyze the responses of N = 20,742 refugees and migrants on the self-reporting global ApartTogether survey. Survey findings indicated that the mental health of refugees and migrants during the COVID-19 pandemic was significantly impacted, particularly for certain subgroups, (i.e., insecure housing situation and residence status, older respondents, and females) who reported experiencing higher levels of increased discrimination and increases in daily life stressors. There is a need to recognize the detrimental mental health impact of the COVID-19 pandemic on particular refugee and migrant groups and to develop interventions that target their unique needs.", "doi": "10.3390/ijerph18126354", "pmid": "34208243", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8296172"}, {"db": "pii", "key": "ijerph18126354"}], "notes": [], "created": "2021-07-05T14:44:02.414Z", "modified": "2023-06-19T14:49:46.737Z"}, {"entity": "publication", "iuid": "3106c8dfdbef48e9a634dbdcc99c2b58", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3106c8dfdbef48e9a634dbdcc99c2b58.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3106c8dfdbef48e9a634dbdcc99c2b58"}}, "title": "Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection.", "authors": [{"family": "Koenecke", "given": "Allison", "initials": "A", "orcid": "0000-0002-6233-8256", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df3eeaa979c5401a9e335cc2de290ddd.json"}}, {"family": "Powell", "given": "Michael", "initials": "M", "orcid": "0000-0003-2749-3725", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8f4a79115a0471b9bcc099f3af2e4c7.json"}}, {"family": "Xiong", "given": "Ruoxuan", "initials": "R"}, {"family": "Shen", "given": "Zhu", "initials": "Z"}, {"family": "Fischer", "given": "Nicole", "initials": "N"}, {"family": "Huq", "given": "Sakibul", "initials": "S"}, {"family": "Khalafallah", "given": "Adham M", "initials": "AM"}, {"family": "Trevisan", "given": "Marco", "initials": "M"}, {"family": "Sparen", "given": "P\u00e4r", "initials": "P", "orcid": "0000-0002-5184-8971", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5f390813419444091c61e211c442c6f.json"}}, {"family": "Carrero", "given": "Juan J", "initials": "JJ"}, {"family": "Nishimura", "given": "Akihiko", "initials": "A"}, {"family": "Caffo", "given": "Brian", "initials": "B"}, {"family": "Stuart", "given": "Elizabeth A", "initials": "EA"}, {"family": "Bai", "given": "Renyuan", "initials": "R"}, {"family": "Staedtke", "given": "Verena", "initials": "V"}, {"family": "Thomas", "given": "David L", "initials": "DL"}, {"family": "Papadopoulos", "given": "Nickolas", "initials": "N"}, {"family": "Kinzler", "given": "Ken W", "initials": "KW"}, {"family": "Vogelstein", "given": "Bert", "initials": "B"}, {"family": "Zhou", "given": "Shibin", "initials": "S"}, {"family": "Bettegowda", "given": "Chetan", "initials": "C"}, {"family": "Konig", "given": "Maximilian F", "initials": "MF", "orcid": "0000-0001-5045-5255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41b9c2c9bca54637959496d449b5aa31.json"}}, {"family": "Mensh", "given": "Brett D", "initials": "BD"}, {"family": "Vogelstein", "given": "Joshua T", "initials": "JT", "orcid": "0000-0003-2487-6237", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb459c056f1f46c28961552ea5180972.json"}}, {"family": "Athey", "given": "Susan", "initials": "S"}], "type": "journal article", "published": "2021-06-11", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "10", "issn-l": null}, "abstract": "In severe viral pneumonia, including Coronavirus disease 2019 (COVID-19), the viral replication phase is often followed by hyperinflammation, which can lead to acute respiratory distress syndrome, multi-organ failure, and death. We previously demonstrated that alpha-1 adrenergic receptor (\u237a 1-AR) antagonists can prevent hyperinflammation and death in mice. Here, we conducted retrospective analyses in two cohorts of patients with acute respiratory distress (ARD, n = 18,547) and three cohorts with pneumonia (n = 400,907). Federated across two ARD cohorts, we find that patients exposed to \u237a1-AR antagonists, as compared to unexposed patients, had a 34% relative risk reduction for mechanical ventilation and death (OR = 0.70, p = 0.021). We replicated these methods on three pneumonia cohorts, all with similar effects on both outcomes. All results were robust to sensitivity analyses. These results highlight the urgent need for prospective trials testing whether prophylactic use of \u237a1-AR antagonists ameliorates lower respiratory tract infection-associated hyperinflammation and death, as observed in COVID-19.", "doi": "10.7554/eLife.61700", "pmid": "34114951", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "61700"}], "notes": [], "created": "2021-06-14T06:34:58.781Z", "modified": "2021-06-14T06:35:13.702Z"}, {"entity": "publication", "iuid": "d1b262f8c4874505b7bbf24f302fe1cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1b262f8c4874505b7bbf24f302fe1cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1b262f8c4874505b7bbf24f302fe1cc"}}, "title": "A Blueprint for High Affinity SARS-CoV-2 Mpro Inhibitors from Activity-Based Compound Library Screening Guided by Analysis of Protein Dynamics.", "authors": [{"family": "Gossen", "given": "Jonas", "initials": "J", "orcid": "0000-0002-0730-6796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f7e23c127404ca1bea9151bd20030a5.json"}}, {"family": "Albani", "given": "Simone", "initials": "S"}, {"family": "Hanke", "given": "Anton", "initials": "A"}, {"family": "Joseph", "given": "Benjamin P", "initials": "BP"}, {"family": "Bergh", "given": "Cathrine", "initials": "C"}, {"family": "Kuzikov", "given": "Maria", "initials": "M", "orcid": "0000-0001-8771-1865", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fcbffac44a748028611a74f2678d8f9.json"}}, {"family": "Costanzi", "given": "Elisa", "initials": "E"}, {"family": "Manelfi", "given": "Candida", "initials": "C"}, {"family": "Storici", "given": "Paola", "initials": "P"}, {"family": "Gribbon", "given": "Philip", "initials": "P"}, {"family": "Beccari", "given": "Andrea R", "initials": "AR"}, {"family": "Talarico", "given": "Carmine", "initials": "C"}, {"family": "Spyrakis", "given": "Francesca", "initials": "F", "orcid": "0000-0002-4016-227X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa1e7500ff8a4440bb7058bcf55c9e4d.json"}}, {"family": "Lindahl", "given": "Erik", "initials": "E"}, {"family": "Zaliani", "given": "Andrea", "initials": "A", "orcid": "0000-0002-1740-8390", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9e31a5fa26f4e69a0815d1443d3ffc9.json"}}, {"family": "Carloni", "given": "Paolo", "initials": "P", "orcid": "0000-0002-9010-0149", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0729cca0143c4847a104475ba5354f94.json"}}, {"family": "Wade", "given": "Rebecca C", "initials": "RC", "orcid": "0000-0001-5951-8670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b13317434734da2a15ec2d4ba4d421d.json"}}, {"family": "Musiani", "given": "Francesco", "initials": "F", "orcid": "0000-0003-0200-1712", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5e6a98e63ce4cbfaf5a3da8cc777485.json"}}, {"family": "Kokh", "given": "Daria B", "initials": "DB", "orcid": "0000-0002-4687-6572", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00f108ee7f4fa58625e61548fea8db.json"}}, {"family": "Rossetti", "given": "Giulia", "initials": "G", "orcid": "0000-0002-2032-4630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/901dadea04014dc88651e5a711325fa8.json"}}], "type": "journal article", "published": "2021-06-11", "journal": {"title": "ACS Pharmacol. Transl. Sci.", "issn": "2575-9108", "volume": "4", "issue": "3", "pages": "1079-1095", "issn-l": null}, "abstract": "The SARS-CoV-2 coronavirus outbreak continues to spread at a rapid rate worldwide. The main protease (Mpro) is an attractive target for anti-COVID-19 agents. Unexpected difficulties have been encountered in the design of specific inhibitors. Here, by analyzing an ensemble of \u223c30 000 SARS-CoV-2 Mpro conformations from crystallographic studies and molecular simulations, we show that small structural variations in the binding site dramatically impact ligand binding properties. Hence, traditional druggability indices fail to adequately discriminate between highly and poorly druggable conformations of the binding site. By performing \u223c200 virtual screenings of compound libraries on selected protein structures, we redefine the protein's druggability as the consensus chemical space arising from the multiple conformations of the binding site formed upon ligand binding. This procedure revealed a unique SARS-CoV-2 Mpro blueprint that led to a definition of a specific structure-based pharmacophore. The latter explains the poor transferability of potent SARS-CoV Mpro inhibitors to SARS-CoV-2 Mpro, despite the identical sequences of the active sites. Importantly, application of the pharmacophore predicted novel high affinity inhibitors of SARS-CoV-2 Mpro, that were validated by in vitro assays performed here and by a newly solved X-ray crystal structure. These results provide a strong basis for effective rational drug design campaigns against SARS-CoV-2 Mpro and a new computational approach to screen protein targets with malleable binding sites.", "doi": "10.1021/acsptsci.0c00215", "pmid": "34136757", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8009102"}], "notes": [], "created": "2021-06-28T18:41:25.728Z", "modified": "2021-07-06T09:01:14.453Z"}, {"entity": "publication", "iuid": "b6cac9c277864b59bfd7fa173087685b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b6cac9c277864b59bfd7fa173087685b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b6cac9c277864b59bfd7fa173087685b"}}, "title": "Self-Perceived Life Satisfaction during the First Wave of the COVID-19 Pandemic in Sweden: A Cross-Sectional Study.", "authors": [{"family": "Brog\u00e5rdh", "given": "Christina", "initials": "C", "orcid": "0000-0002-9249-9421", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12898e4072414c3ea7bd1fd6dc3be4d4.json"}}, {"family": "Hammarlund", "given": "Catharina Sj\u00f6dahl", "initials": "CS", "orcid": "0000-0001-6071-6922", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8a4960ca87043e3b465c63e9256c96f.json"}}, {"family": "Eek", "given": "Frida", "initials": "F"}, {"family": "Stigmar", "given": "Kjerstin", "initials": "K"}, {"family": "Lindgren", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-9910-0380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a15011595cd540e6aec99ce62a9b70a4.json"}}, {"family": "Schouenborg", "given": "Anna Trulsson", "initials": "AT"}, {"family": "Hansson", "given": "Eva Ekvall", "initials": "EE"}], "type": "journal article", "published": "2021-06-09", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "12", "pages": "6234"}, "abstract": "Currently, there is limited knowledge on how the Swedish strategy with more lenient public health restrictions during the COVID-19 pandemic has influenced people's life satisfaction. Here, we investigated self-reported life satisfaction during the first wave of the pandemic in Sweden, and perceived changes in life satisfaction in relation to various sociodemographic factors. A total of 1082 people (mean age 48 (SD 12.2); 82% women) responded to an online survey during autumn 2020 including the \"Life Satisfaction Questionnaire-11\". A majority (69%) were satisfied with life as a whole, and with other important life domains, with the exception of contact with friends and sexual life. An equal share reported that life as a whole had either deteriorated (28%) or improved (29%). Of those that perceived a deterioration, 95% considered it to be due to the pandemic. Regarding deteriorated satisfaction with life as a whole, higher odds were found in the following groups: having no children living at home; being middle aged; having other sources of income than being employed; and having a chronic disease. The Swedish strategy might have contributed to the high proportion of satisfied people. Those who perceived a deterioration in life satisfaction may, however, need attention from Swedish Welfare Authorities.", "doi": "10.3390/ijerph18126234", "pmid": "34207621", "labels": {"Category: Public Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8296066"}, {"db": "pii", "key": "ijerph18126234"}], "notes": [], "created": "2021-07-05T14:43:45.842Z", "modified": "2023-06-19T14:34:11.088Z"}, {"entity": "publication", "iuid": "5e62d79cca764b5b8326f8e1e1f71a28", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e62d79cca764b5b8326f8e1e1f71a28.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e62d79cca764b5b8326f8e1e1f71a28"}}, "title": "SARS-CoV-2 Variants of Interest and Concern naming scheme conducive for global discourse.", "authors": [{"family": "Konings", "given": "Frank", "initials": "F", "orcid": "0000-0003-0070-4457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6676f07da06e4af68d3613f829990251.json"}}, {"family": "Perkins", "given": "Mark D", "initials": "MD"}, {"family": "Kuhn", "given": "Jens H", "initials": "JH"}, {"family": "Pallen", "given": "Mark J", "initials": "MJ", "orcid": "0000-0003-1807-3657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62d797d8942c4121a70b1bd77a0d4e9e.json"}}, {"family": "Alm", "given": "Erik J", "initials": "EJ"}, {"family": "Archer", "given": "Brett N", "initials": "BN"}, {"family": "Barakat", "given": "Amal", "initials": "A"}, {"family": "Bedford", "given": "Trevor", "initials": "T"}, {"family": "Bhiman", "given": "Jinal N", "initials": "JN"}, {"family": "Caly", "given": "Leon", "initials": "L"}, {"family": "Carter", "given": "Lisa L", "initials": "LL"}, {"family": "Cullinane", "given": "Anne", "initials": "A"}, {"family": "de Oliveira", "given": "Tulio", "initials": "T", "orcid": "0000-0002-3027-5254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3dadcb78141a496ba76769d69667bf79.json"}}, {"family": "Druce", "given": "Julian", "initials": "J"}, {"family": "El Masry", "given": "Ihab", "initials": "I"}, {"family": "Evans", "given": "Roger", "initials": "R"}, {"family": "Gao", "given": "George F", "initials": "GF"}, {"family": "Gorbalenya", "given": "Alexander E", "initials": "AE", "orcid": "0000-0002-4967-7341", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76287aa33e034511934c0d16214ecaec.json"}}, {"family": "Hamblion", "given": "Esther", "initials": "E"}, {"family": "Herring", "given": "Belinda L", "initials": "BL"}, {"family": "Hodcroft", "given": "Emma", "initials": "E"}, {"family": "Holmes", "given": "Edward C", "initials": "EC", "orcid": "0000-0001-9596-3552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d784e4faf11463993992797e354dfc9.json"}}, {"family": "Kakkar", "given": "Manish", "initials": "M"}, {"family": "Khare", "given": "Shagun", "initials": "S"}, {"family": "Koopmans", "given": "Marion P G", "initials": "MPG", "orcid": "0000-0002-5204-2312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80d7f1e97b934289b7095013ef6e998d.json"}}, {"family": "Korber", "given": "Bette", "initials": "B"}, {"family": "Leite", "given": "Juliana", "initials": "J"}, {"family": "MacCannell", "given": "Duncan", "initials": "D"}, {"family": "Marklewitz", "given": "Marco", "initials": "M"}, {"family": "Maurer-Stroh", "given": "Sebastian", "initials": "S"}, {"family": "Rico", "given": "Jairo Andres Mendez", "initials": "JAM"}, {"family": "Munster", "given": "Vincent J", "initials": "VJ", "orcid": "0000-0002-2288-3196", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1f2569e7fe5442d968b3d89c88599d1.json"}}, {"family": "Neher", "given": "Richard", "initials": "R", "orcid": "0000-0003-2525-1407", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a31564f19214fbdb275578ed05a6bcb.json"}}, {"family": "Munnink", "given": "Bas Oude", "initials": "BO", "orcid": "0000-0002-9394-1189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19923669d04a47ebb5c7c93d20ecedc3.json"}}, {"family": "Pavlin", "given": "Boris I", "initials": "BI"}, {"family": "Peiris", "given": "Malik", "initials": "M", "orcid": "0000-0001-8217-5995", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9395f3f6fc44427b0dbf04988bfde22.json"}}, {"family": "Poon", "given": "Leo", "initials": "L", "orcid": "0000-0002-9101-7953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6595eec1d268410fad9018a8c7dd20c6.json"}}, {"family": "Pybus", "given": "Oliver", "initials": "O", "orcid": "0000-0002-8797-2667", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3770f4e971b34afbb61f6276d43767a1.json"}}, {"family": "Rambaut", "given": "Andrew", "initials": "A", "orcid": "0000-0003-4337-3707", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d25e62e17c243f3ab72304ca504e296.json"}}, {"family": "Resende", "given": "Paola", "initials": "P", "orcid": "0000-0002-2884-3662", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b51db0165c14686b31f624bf075f18b.json"}}, {"family": "Subissi", "given": "Lorenzo", "initials": "L", "orcid": "0000-0001-5147-575X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/454c226e834a4829a330df1c4b604855.json"}}, {"family": "Thiel", "given": "Volker", "initials": "V", "orcid": "0000-0002-5783-0887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c6d7b184da743e5975d3009cad5a802.json"}}, {"family": "Tong", "given": "Suxiang", "initials": "S"}, {"family": "van der Werf", "given": "Sylvie", "initials": "S", "orcid": "0000-0002-1148-4456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/610e999fc3fa4d24aceecf5a13122ecf.json"}}, {"family": "von Gottberg", "given": "Anne", "initials": "A"}, {"family": "Ziebuhr", "given": "John", "initials": "J", "orcid": "0000-0002-5741-8825", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4588eb2e70a4dafa2bdf92849f68837.json"}}, {"family": "Van Kerkhove", "given": "Maria D", "initials": "MD"}], "type": "journal article", "published": "2021-06-09", "journal": {"title": "Nat Microbiol", "issn": "2058-5276", "issn-l": null}, "abstract": null, "doi": "10.1038/s41564-021-00932-w", "pmid": "34108654", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41564-021-00932-w"}], "notes": [], "created": "2021-06-11T05:06:16.140Z", "modified": "2021-06-11T05:06:34.710Z"}, {"entity": "publication", "iuid": "e442369dddb84c968e6528b2c18d7536", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e442369dddb84c968e6528b2c18d7536.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e442369dddb84c968e6528b2c18d7536"}}, "title": "Reduction of pediatric emergency visits during the COVID-19 pandemic in a region with open preschools and schools.", "authors": [{"family": "Rhedin", "given": "Samuel Arthur", "initials": "SA"}, {"family": "Ryd Rinder", "given": "Malin", "initials": "M"}, {"family": "Hildenwall", "given": "Helena", "initials": "H"}, {"family": "Herlenius", "given": "Eric", "initials": "E"}, {"family": "Hertting", "given": "Olof", "initials": "O"}, {"family": "Luthander", "given": "Joachim", "initials": "J"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Nijman", "given": "Ruud", "initials": "R"}, {"family": "Olsson-\u00c5kefeldt", "given": "Selma", "initials": "S"}, {"family": "Alfven", "given": "Tobias", "initials": "T"}], "type": "journal article", "published": "2021-06-09", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": null, "issue": null, "pages": null}, "abstract": "Previous studies have reported a reduction in pediatric emergency visits for communicable diseases during the COVID-19 pandemic, which has been related to the use of face masks and school closures. As Sweden imposed less strict restrictions as compared to most countries we aimed to assess the effect of the behavioral changes, however without school closures and general usage of face masks in the society, on the spread of communicable diseases in children. We calculated cumulative incidences of pediatric emergency visits for lower respiratory tract infections (LRTIs), gastroenteritis and as a control diagnosis urinary tract infections (UTIs) comparing 2020 with 2018-2019. Our results suggests that the behavioral changes including improved basal hygiene routines and physical distancing, had a major impact on the disease transmission of LRTIs (cumulative incidence 0.24% in 2020 versus 0.57% during 2018-2019, p<0.001) and gastroenteritis (0.26% versus 0.87%, p<0.001) in children but observed a small increase in UTIs (0.22% versus 0.20%, p=0.01). This raises the question on to what extent some of these recommendations can and should be extended in the post pandemic era.", "doi": "10.1111/apa.15978", "pmid": "34107120", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-10T10:14:00.072Z", "modified": "2021-07-14T09:35:15.224Z"}, {"entity": "publication", "iuid": "415035fac5ab476b81c0a067ef352a19", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/415035fac5ab476b81c0a067ef352a19.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/415035fac5ab476b81c0a067ef352a19"}}, "title": "COVID-19 and Health Care Leaders: How Could Emotional Intelligence Be a Helpful Resource during a Pandemic?", "authors": [{"family": "Rossettini", "given": "Giacomo", "initials": "G"}, {"family": "Conti", "given": "Cristiana", "initials": "C"}, {"family": "Suardelli", "given": "Martina", "initials": "M"}, {"family": "Geri", "given": "Tommaso", "initials": "T"}, {"family": "Palese", "given": "Alvisa", "initials": "A"}, {"family": "Turolla", "given": "Andrea", "initials": "A"}, {"family": "Lovato", "given": "Andrea", "initials": "A"}, {"family": "Gianola", "given": "Silvia", "initials": "S"}, {"family": "Dell'Isola", "given": "Andrea", "initials": "A"}], "type": "journal article", "published": "2021-06-09", "journal": {"title": "Phys Ther", "issn": "1538-6724", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1093/ptj/pzab143", "pmid": "34101807", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6294530"}], "notes": [], "created": "2021-06-09T19:03:08.563Z", "modified": "2021-07-14T09:37:46.670Z"}, {"entity": "publication", "iuid": "61d6b962006344b99192d107bf56ae86", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61d6b962006344b99192d107bf56ae86.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61d6b962006344b99192d107bf56ae86"}}, "title": "Assessing the effects of calculated inaction on national responses to the COVID-19 crisis.", "authors": [{"family": "Zahariadis", "given": "Nikolaos", "initials": "N", "orcid": "0000-0003-2457-0561", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51bd7d14c9584d04a7eafba7f440c34c.json"}}, {"family": "Ceccoli", "given": "Stephen", "initials": "S", "orcid": "0000-0003-3789-061X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/036f98a2d87d464d98ddc7dc876467cd.json"}}, {"family": "Petridou", "given": "Evangelia", "initials": "E", "orcid": "0000-0001-7316-4899", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21de455914874bdf8fbaf544e51053b0.json"}}], "type": "journal article", "published": "2021-06-09", "journal": {"title": "Risk Hazards Crisis Public Policy", "issn": "1944-4079", "issn-l": null}, "abstract": "How does calculated inaction affect subsequent responses to the COVID-19 crisis? We argue that when governments employ calculated inaction during crises, they are more likely to manipulate the technical (scientific) aspects of national responses and highlight symbolic politics, each in the name of projecting power and strengthening the regime's governing authority. Using theoretical insight from McConnell and 't Hart's policy inaction typology, we investigate sense-making and crisis response narratives in China and Greece. We conclude with implications for policymaking and the crisis management literature.", "doi": "10.1002/rhc3.12230", "pmid": "34226845", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "RHC312230"}, {"db": "pmc", "key": "PMC8242484"}], "notes": [], "created": "2021-08-06T08:41:54.181Z", "modified": "2021-08-06T08:41:54.277Z"}, {"entity": "publication", "iuid": "7b0d6322d30546cba83126492632adeb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b0d6322d30546cba83126492632adeb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b0d6322d30546cba83126492632adeb"}}, "title": "Impact of COVID-19 pandemic on mental health and health behaviors in Swedish adolescents.", "authors": [{"family": "Chen", "given": "Yun", "initials": "Y"}, {"family": "Osika", "given": "Walter", "initials": "W"}, {"family": "Henriksson", "given": "G\u00f6ran", "initials": "G"}, {"family": "Dahlstrand", "given": "Johan", "initials": "J"}, {"family": "Friberg", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2021-06-08", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": null, "issue": null, "pages": "14034948211021724"}, "abstract": "There is an urgent need to explore the impact of the COVID-19 pandemic on adolescent mental health and health behaviours. To date, there are no such studies on Swedish adolescents. As COVID-19 emerged in the middle of our ongoing 2-year follow-up examination of the Study of Adolescence Resilience and Stress, we had the unique opportunity to use the corona outbreak as a 'natural experiment' to study the impact of COVID-19 on 15-year-old adolescents in Sweden.\r\n\r\nAdolescents (baseline age 13.6\u00b10.4 years) were recruited from schools in western Sweden (during the COVID-19 outbreak schools were kept open for those under 16 years of age). The COVID-19 pandemic reached Sweden on 31 January 2020. A total of 1316 adolescents answered the 2-year follow-up survey before (unexposed to COVID-19 pandemic, controls) and 584 after 1 February 2020 (COVID19-exposed). Data on stress, psychosomatic symptoms, happiness, relationships with parents and peers, school and health behaviours were collected.\r\n\r\nAdolescents reported higher levels of stress and psychosomatic symptoms and lower levels of happiness at follow-up compared to baseline. These changes occurred to a similar extent in both the control and COVID-19-exposed groups. Likewise, the COVID-19-exposed group showed no deterioration in peer relations or relations with parents versus controls. We did not find any significant differences between groups regarding sleep duration and physical activity. Conclusions: Swedish adolescents exposed to COVID-19 during most of 2020 showed no differences in longitudinal changes in mental health, relationships with parents and peers, and health behaviours compared to those not exposed to COVID-19.", "doi": "10.1177/14034948211021724", "pmid": "34100665", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Funder: H2020": null, "Funder: VR": null}, "xrefs": [], "notes": [], "created": "2021-06-09T19:04:07.985Z", "modified": "2021-07-14T09:24:47.762Z"}, {"entity": "publication", "iuid": "daeeea3c68554772b7f455f7328bfc44", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/daeeea3c68554772b7f455f7328bfc44.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/daeeea3c68554772b7f455f7328bfc44"}}, "title": "Dying from cancer with COVID-19: age, sex, socio-economic status, and comorbidities", "authors": [{"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "Hedman", "given": "Christel", "initials": "C"}, {"family": "Adlitzer", "given": "Helena", "initials": "H"}, {"family": "Schultz", "given": "Torbj\u00f6rn", "initials": "T"}], "type": "journal-article", "published": "2021-06-08", "journal": {"title": "Acta Oncologica", "issn": "0284-186X", "issn-l": null, "volume": null, "issue": null, "pages": "1-6"}, "abstract": "The COVID-19 pandemic has caused excess deaths (all causes) and has disproportionately affected the elderly with certain characteristics.\r\n\r\nTo study how COVID-19 affected cancer deaths regarding age, sex, socio-economic status, comorbidities, and access to palliative care. An additional objective was to study changes in place of care and death.\r\n\r\nA descriptive, retrospective study of all cancer patients who died during March-May 2020 in the Stockholm region, n = 1467 of which 278 died with a COVID-19 diagnosis, compared with deaths in 2016-2019. The Stockholm Regional Council's central data warehouse was used. T-tests, 95% CI, Wilcoxon and chi-squared tests were used for comparisons.\r\n\r\nThere were excess cancer deaths compared with 2016-2019 ( p < 0.001) and patients dying with a COVID-19 diagnosis were older (79.7 vs. 75.9 years, p < 0.0001), more often male (67% vs. 55%, p < 0.0001), and had more comorbidities (Charlson Comorbidity Index 1.6 vs. 1.1, p < 0.0001). Patients with COVID-19 more seldom had access to palliative care (34% vs. 59%, p = 0.008), had more changes in place of care during the last two weeks of life (p < 0.0001) and died more often in acute hospitals (34% vs. 14%, p < 0.0001). For the subgroup with access to palliative care, the hospital deaths for individuals with and without a COVID-19 diagnosis were 11% and 4%, respectively (p = 0.008).\r\n\r\nCancer patients dying with a COVID-19 diagnosis were older, more often male, and had more comorbidities. A COVID-19 diagnosis negatively affected the probability of being admitted to specialized palliative care and increased the likelihood of dying in an acute hospital.", "doi": "10.1080/0284186x.2021.1934536", "pmid": "34101521", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-09T19:03:41.769Z", "modified": "2021-07-14T09:23:35.833Z"}, {"entity": "publication", "iuid": "b3310f859ee940a4b51f6c4b608645f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b3310f859ee940a4b51f6c4b608645f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b3310f859ee940a4b51f6c4b608645f4"}}, "title": "Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2", "authors": [{"family": "O'Toole", "given": "A", "initials": "A"}, {"family": "Hill", "given": "V", "initials": "V"}], "type": "journal article", "published": "2021-06-07", "journal": {"title": "Wellcome Open Res", "issn": "2398-502X", "issn-l": null, "volume": "6", "issue": null, "pages": "121"}, "abstract": "Late in 2020, two genetically-distinct clusters of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with mutations of biological concern were reported, one in the United Kingdom and one in South Africa. Using a combination of data from routine surveillance, genomic sequencing and international travel we track the international dispersal of lineages B.1.1.7 and B.1.351 (variant 501Y-V2). We account for potential biases in genomic surveillance efforts by including passenger volumes from location of where the lineage was first reported, London and South Africa respectively. Using the software tool grinch (global report investigating novel coronavirus haplotypes), we track the international spread of lineages of concern with automated daily reports, Further, we have built a custom tracking website (cov-lineages.org/global_report.html) which hosts this daily report and will continue to include novel SARS-CoV-2 lineages of concern as they are detected.", "doi": "https://doi.org/10.12688/wellcomeopenres.16661.1", "pmid": "34095513", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pmc", "key": "PMC8176267"}, {"db": "URL", "key": "https://zenodo.org/record/4642401#.YZZRQS8w3OQ", "description": "Accession IDs included in publication Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2"}, {"db": "URL", "key": "https://zenodo.org/record/4704471#.YZZRyS8w3OQ", "description": "Supplementary materials with group affiliations for Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2"}, {"db": "URL", "key": "https://zenodo.org/record/4640140#.YZZRRy8w1TY", "description": "Data underlying the cov-lineages.org website"}], "notes": [], "created": "2021-06-07T15:39:21.116Z", "modified": "2021-11-18T13:17:11.237Z"}, {"entity": "publication", "iuid": "b67d71cac8ed4f03995e13a88ac7e12a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b67d71cac8ed4f03995e13a88ac7e12a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b67d71cac8ed4f03995e13a88ac7e12a"}}, "title": "Strategies to Improve Antimicrobial Utilization with a Special Focus on Developing Countries.", "authors": [{"family": "Godman", "given": "Brian", "initials": "B", "orcid": "0000-0001-6539-6972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e76103610619453b84eab8de36f169cc.json"}}, {"family": "Egwuenu", "given": "Abiodun", "initials": "A", "orcid": "0000-0002-9369-4771", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70e982f868684b5780a54ecc8aa5a943.json"}}, {"family": "Haque", "given": "Mainul", "initials": "M", "orcid": "0000-0002-6124-7993", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b474f4ad9837460e84f88097a5cd639f.json"}}, {"family": "Malande", "given": "Oliver Ombeva", "initials": "OO"}, {"family": "Schellack", "given": "Natalie", "initials": "N"}, {"family": "Kumar", "given": "Santosh", "initials": "S", "orcid": "0000-0002-5117-7872", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e56ccd71c894b54a1412fc4a53652c2.json"}}, {"family": "Saleem", "given": "Zikria", "initials": "Z", "orcid": "0000-0003-3202-6347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/029d4b30cc724148a1225090d3f063ee.json"}}, {"family": "Sneddon", "given": "Jacqueline", "initials": "J"}, {"family": "Hoxha", "given": "Iris", "initials": "I"}, {"family": "Islam", "given": "Salequl", "initials": "S"}, {"family": "Mwita", "given": "Julius", "initials": "J"}, {"family": "do Nascimento", "given": "Renata Cristina Rezende Macedo", "initials": "RCRM", "orcid": "0000-0001-7756-2157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eec0a62241f4ea8931a95d92f34fa73.json"}}, {"family": "Dias God\u00f3i", "given": "Isabella Piassi", "initials": "IP", "orcid": "0000-0002-0568-6625", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6ade8b9c4e94a64add5b0d5b6911a27.json"}}, {"family": "Niba", "given": "Loveline Lum", "initials": "LL", "orcid": "0000-0002-5938-4913", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/321efd54c80f410a97a4887bcbb9e4d5.json"}}, {"family": "Amu", "given": "Adefolarin A", "initials": "AA"}, {"family": "Acolatse", "given": "Joseph", "initials": "J", "orcid": "0000-0001-6556-3208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c03eeda55764c609acb5cb91dacbbd3.json"}}, {"family": "Incoom", "given": "Robert", "initials": "R"}, {"family": "Sefah", "given": "Israel Abebrese", "initials": "IA", "orcid": "0000-0001-6963-0519", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/073a513f62804d9fb48c4f846c747c54.json"}}, {"family": "Opanga", "given": "Sylvia", "initials": "S"}, {"family": "Kurdi", "given": "Amanj", "initials": "A", "orcid": "0000-0001-5036-1988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be9bf17786754363929dc0faaae8c323.json"}}, {"family": "Chikowe", "given": "Ibrahim", "initials": "I", "orcid": "0000-0002-8231-9140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9eec6427097437eb172355a62854faf.json"}}, {"family": "Khuluza", "given": "Felix", "initials": "F"}, {"family": "Kibuule", "given": "Dan", "initials": "D", "orcid": "0000-0002-6908-2177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4344137451d04535a5875183b9abc24e.json"}}, {"family": "Ogunleye", "given": "Olayinka O", "initials": "OO"}, {"family": "Olalekan", "given": "Adesola", "initials": "A", "orcid": "0000-0002-8921-1909", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4780e3a28e2b44a0ac5c20cecc469852.json"}}, {"family": "Markovic-Pekovic", "given": "Vanda", "initials": "V"}, {"family": "Meyer", "given": "Johanna C", "initials": "JC"}, {"family": "Alfadl", "given": "Abubakr", "initials": "A"}, {"family": "Phuong", "given": "Thuy Nguyen Thi", "initials": "TNT"}, {"family": "Kalungia", "given": "Aubrey C", "initials": "AC"}, {"family": "Campbell", "given": "Stephen", "initials": "S"}, {"family": "Pisana", "given": "Alice", "initials": "A"}, {"family": "Wale", "given": "Janney", "initials": "J"}, {"family": "Seaton", "given": "R Andrew", "initials": "RA"}], "type": "journal article", "published": "2021-06-07", "journal": {"title": "Life (Basel)", "issn": "2075-1729", "issn-l": null, "volume": "11", "issue": "6", "pages": null}, "abstract": "Antimicrobial resistance (AMR) is a high priority across countries as it increases morbidity, mortality and costs. Concerns with AMR have resulted in multiple initiatives internationally, nationally and regionally to enhance appropriate antibiotic utilization across sectors to reduce AMR, with the overuse of antibiotics exacerbated by the COVID-19 pandemic. Effectively tackling AMR is crucial for all countries. Principally a narrative review of ongoing activities across sectors was undertaken to improve antimicrobial use and address issues with vaccines including COVID-19. Point prevalence surveys have been successful in hospitals to identify areas for quality improvement programs, principally centering on antimicrobial stewardship programs. These include reducing prolonged antibiotic use to prevent surgical site infections. Multiple activities centering on education have been successful in reducing inappropriate prescribing and dispensing of antimicrobials in ambulatory care for essentially viral infections such as acute respiratory infections. It is imperative to develop new quality indicators for ambulatory care given current concerns, and instigate programs with clear public health messaging to reduce misinformation, essential for pandemics. Regular access to effective treatments is needed to reduce resistance to treatments for HIV, malaria and tuberculosis. Key stakeholder groups can instigate multiple initiatives to reduce AMR. These need to be followed up.", "doi": "10.3390/life11060528", "pmid": "34200116", "labels": {"Type: Review": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8229985"}, {"db": "pii", "key": "life11060528"}], "notes": [], "created": "2021-07-05T14:33:03.361Z", "modified": "2023-06-19T07:30:35.555Z"}, {"entity": "publication", "iuid": "af7bab2d24e543b19d644dbd8546b0a7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/af7bab2d24e543b19d644dbd8546b0a7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/af7bab2d24e543b19d644dbd8546b0a7"}}, "title": "SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease?", "authors": [{"family": "Sancho-Shimizu", "given": "Vanessa", "initials": "V"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A"}, {"family": "Biggs", "given": "Catherine M", "initials": "CM"}, {"family": "Toubiana", "given": "Julie", "initials": "J"}, {"family": "Lucas", "given": "Carrie L", "initials": "CL"}, {"family": "Henrickson", "given": "Sarah E", "initials": "SE"}, {"family": "Belot", "given": "Alexandre", "initials": "A"}, {"family": "MIS-C@CHGE", "given": "", "initials": ""}, {"family": "Tangye", "given": "Stuart G", "initials": "SG"}, {"family": "Milner", "given": "Joshua D", "initials": "JD"}, {"family": "Levin", "given": "Michael", "initials": "M"}, {"family": "Abel", "given": "Laurent", "initials": "L"}, {"family": "Bogunovic", "given": "Dusan", "initials": "D"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}], "type": "journal article", "published": "2021-06-07", "journal": {"title": "J Exp Med", "issn": "1540-9538", "volume": "218", "issue": "6", "issn-l": null}, "abstract": "Multisystem inflammatory syndrome in children (MIS-C) emerged in April 2020 in communities with high COVID-19 rates. This new condition is heterogenous but resembles Kawasaki disease (KD), a well-known but poorly understood and clinically heterogenous pediatric inflammatory condition for which weak associations have been found with a myriad of viral illnesses. Epidemiological data clearly indicate that SARS-CoV-2 is the trigger for MIS-C, which typically occurs about 1 mo after infection. These findings support the hypothesis of viral triggers for the various forms of classic KD. We further suggest that rare inborn errors of immunity (IEIs) altering the immune response to SARS-CoV-2 may underlie the pathogenesis of MIS-C in some children. The discovery of monogenic IEIs underlying MIS-C would shed light on its pathogenesis, paving the way for a new genetic approach to classic KD, revisited as a heterogeneous collection of IEIs to viruses.", "doi": "10.1084/jem.20210446", "pmid": "33904890", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "212029"}], "notes": [], "created": "2021-04-29T10:16:49.682Z", "modified": "2021-04-29T10:16:49.704Z"}, {"entity": "publication", "iuid": "e780251b40974ddea6e2be08b3dc8076", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e780251b40974ddea6e2be08b3dc8076.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e780251b40974ddea6e2be08b3dc8076"}}, "title": "Missed nursing care during the COVID-19 pandemic: a comparative observational study.", "authors": [{"family": "von Vogelsang", "given": "Ann-Christin", "initials": "A"}, {"family": "G\u00f6ransson", "given": "Katarina E", "initials": "KE"}, {"family": "Falk", "given": "Ann-Charlotte", "initials": "A"}, {"family": "Nymark", "given": "Carolin", "initials": "C"}], "type": "journal article", "published": "2021-06-07", "journal": {"title": "J Nurs Manag", "issn": "1365-2834", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To evaluate frequencies, types of, and reasons for missed nursing care during the COVID-19 pandemic at inpatient wards in a highly specialized university hospital.\r\n\r\nRegistered nurse/patient ratio and nursing competence is known to affect patient outcomes. The first wave of the COVID-19 pandemic entailed novel ways for staffing to meet the expected increased acute care demand, which potentially could impact on quality of care.\r\n\r\nA comparative cross-sectional study was conducted, using the MISSCARE Survey. A sample of nursing staff during the first wave of the COVID-19 pandemic (n=130) was compared with a reference sample (n=157).\r\n\r\nFew differences between samples concerning elements of missed care, and no significant differences concerning reasons for missed care were found. Most participants perceived the quality of care and the patient safety to be good.\r\n\r\nThe results may be explained by three factors: maintained registered nurse/patient ratio, patients' dependency levels and that nursing managers could maintain the staffing needs with a sufficient skill mix.\r\n\r\nNursing managers impact on the occurrence of MNC; to provide a sufficient registered nurse/patient ratio and skill mix when staffing. They play an important role in anticipatory planning, and during infectious diseases outbreaks.", "doi": "10.1111/jonm.13392", "pmid": "34097799", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-08T09:02:41.566Z", "modified": "2021-07-14T09:21:04.995Z"}, {"entity": "publication", "iuid": "00ce2e2616f845da86a5b7e7c6321f81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/00ce2e2616f845da86a5b7e7c6321f81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/00ce2e2616f845da86a5b7e7c6321f81"}}, "title": "Long-term consequences in critically ill COVID-19 patients: a prospective cohort study.", "authors": [{"family": "Schandl", "given": "Anna", "initials": "A"}, {"family": "Hedman", "given": "Anders", "initials": "A"}, {"family": "Lyng\u00e5", "given": "Patrik", "initials": "P"}, {"family": "Fathi Tachinabad", "given": "Sozan", "initials": "S"}, {"family": "Svefors", "given": "Jessica", "initials": "J"}, {"family": "Ro\u00ebl", "given": "Mari", "initials": "M"}, {"family": "Geborek", "given": "Anne", "initials": "A"}, {"family": "Franko", "given": "Mikael Andersson", "initials": "MA"}, {"family": "S\u00f6derberg", "given": "M\u00e5rten", "initials": "M"}, {"family": "Darlington", "given": "Pernilla", "initials": "P"}], "type": "journal article", "published": "2021-06-07", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "volume": null, "issue": null, "issn-l": "0001-5172"}, "abstract": "COVID-19 can cause severe disease with need of treatment in the intensive care unit (ICU) for several weeks. Increased knowledge is needed about the long-term consequences.\n\nThis is a single-center prospective follow-up study of COVID-19 patients admitted to the ICU for respiratory organ support between March and July 2020. Patients with invasive ventilation were compared with those with high-flow nasal oxygen (HFNO) or non-invasive ventilation (NIV) regarding functional outcome and health-related qualify of life. The mean follow-up time was 5 months after ICU discharge and included clinical history, three well-validated questionnaires about health-related quality of life and psychological health, pulmonary function test, 6-minute walk test (6MWT) and work ability. Data were analyzed with multivariable general linear and logistic regression models with 95% confidence intervals.\n\nAmong 248 ICU patients, 200 patients survived. Of these, 113 patients came for follow-up. Seventy patients (62%) had received invasive ventilation. Most patients reported impaired health-related quality of life. Approximately one third suffered from posttraumatic stress, anxiety and depression. Twenty-six percent had reduced total lung capacity, 34% had reduced 6MWT and 50% worked fulltime. The outcomes were similar regardless of ventilatory support, but invasive ventilation was associated with more bodily pain (MSD -19, 95% CI: -32 to -5) and <80% total lung capacity (OR 4.1, 95% CI: 1.3-16.5).\n\nAmong survivors of Covid-19 who required respiratory organ support, outcomes 5 months after discharge from ICU were largely similar among those requiring invasive compared to non-invasive ventilation.", "doi": "10.1111/aas.13939", "pmid": "34097753", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-08T09:01:42.327Z", "modified": "2021-06-08T09:05:02.198Z"}, {"entity": "publication", "iuid": "c8464d3e58c54986b1b603fae7036672", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c8464d3e58c54986b1b603fae7036672.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c8464d3e58c54986b1b603fae7036672"}}, "title": "A Cross-Sectional Survey on Medication Management Practices for Noncommunicable Diseases in Europe During the Second Wave of the COVID-19 Pandemic", "authors": [{"family": "\u00c1gh", "given": "Tam\u00e1s", "initials": "T"}, {"family": "van Boven", "given": "Job FM", "initials": "JF"}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Menditto", "given": "Enrica", "initials": "E"}, {"family": "Pinnock", "given": "Hilary", "initials": "H"}, {"family": "Tsiligianni", "given": "Ioanna", "initials": "I"}, {"family": "Petrova", "given": "Guenka", "initials": "G"}, {"family": "Poto\u010dnjak", "given": "Ines", "initials": "I"}, {"family": "Kamberi", "given": "Fatjona", "initials": "F"}, {"family": "Kardas", "given": "Przemyslaw", "initials": "P"}, {"family": null, "given": "", "initials": ""}], "type": "journal-article", "published": "2021-06-07", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "12", "issn-l": "1663-9812"}, "abstract": null, "doi": "10.3389/fphar.2021.685696", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:16:17.183Z", "modified": "2021-06-28T18:16:17.194Z"}, {"entity": "publication", "iuid": "a39156b910c74d5eab4c6f6bb1e90627", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a39156b910c74d5eab4c6f6bb1e90627.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a39156b910c74d5eab4c6f6bb1e90627"}}, "title": "Open science saves lives: lessons from the COVID-19 pandemic.", "authors": [{"family": "Besan\u00e7on", "given": "Lonni", "initials": "L"}, {"family": "Peiffer-Smadja", "given": "Nathan", "initials": "N"}, {"family": "Segalas", "given": "Corentin", "initials": "C"}, {"family": "Jiang", "given": "Haiting", "initials": "H"}, {"family": "Masuzzo", "given": "Paola", "initials": "P"}, {"family": "Smout", "given": "Cooper", "initials": "C"}, {"family": "Billy", "given": "Eric", "initials": "E"}, {"family": "Deforet", "given": "Maxime", "initials": "M"}, {"family": "Leyrat", "given": "Cl\u00e9mence", "initials": "C"}], "type": "letter", "published": "2021-06-05", "journal": {"title": "BMC Med Res Methodol", "issn": "1471-2288", "issn-l": null, "volume": "21", "issue": "1", "pages": "117"}, "abstract": "In the last decade Open Science principles have been successfully advocated for and are being slowly adopted in different research communities. In response to the COVID-19 pandemic many publishers and researchers have sped up their adoption of Open Science practices, sometimes embracing them fully and sometimes partially or in a sub-optimal manner. In this article, we express concerns about the violation of some of the Open Science principles and its potential impact on the quality of research output. We provide evidence of the misuses of these principles at different stages of the scientific process. We call for a wider adoption of Open Science practices in the hope that this work will encourage a broader endorsement of Open Science principles and serve as a reminder that science should always be a rigorous process, reliable and transparent, especially in the context of a pandemic where research findings are being translated into practice even more rapidly. We provide all data and scripts at https://osf.io/renxy/ .", "doi": "10.1186/s12874-021-01304-y", "pmid": "34090351", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12874-021-01304-y"}], "notes": [], "created": "2021-06-07T14:16:08.799Z", "modified": "2021-06-08T08:47:19.991Z"}, {"entity": "publication", "iuid": "d347c79105404ea8a601a07b6e2c0236", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d347c79105404ea8a601a07b6e2c0236.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d347c79105404ea8a601a07b6e2c0236"}}, "title": "Vaccine allergy: evidence to consider for COVID-19 vaccines.", "authors": [{"family": "Nilsson", "given": "Lennart", "initials": "L"}, {"family": "Csuth", "given": "\u00c1gnes", "initials": "\u00c1"}, {"family": "Storsaeter", "given": "Jann", "initials": "J"}, {"family": "Garvey", "given": "Lene H", "initials": "LH"}, {"family": "Jenmalm", "given": "Maria C", "initials": "MC"}], "type": "journal article", "published": "2021-06-04", "journal": {"title": "Curr Opin Allergy Clin Immunol", "issn": "1473-6322", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Whereas the COVID-19 pandemic has changed our lives worldwide, we hope that vaccination can combat the disease. We propose how to evaluate suspected severe allergic reactions to the vaccines so that as many as possible may be safely vaccinated.\r\n\r\nRare cases of severe allergic reactions after COVID-19 vaccination have been observed, seemingly at a higher frequency than for other vaccines. Few excipients are likely to have caused these reactions. IgE-mediated reactions to polyethylene glycol (PEG) and its derivatives are the most suspected, albeit hitherto unproven, causes. We suggest to make a diagnosis based on skin tests with PEG and PEG derivatives and that these be considered in relation to the decisions required before the first and the second vaccine dose. A vaccine without these excipients is available, but published data about its side effects are limited.\r\n\r\nThe underlying immunological mechanisms of the rare severe allergic reactions to the COVID-19 vaccines are poorly understood and need to be clarified. Identifying those who have an undiagnosed allergy to PEG and PEG derivatives is crucial before vaccination, and these substances are found in laxatives, cosmetics and in 30% of all our medications today.", "doi": "10.1097/ACI.0000000000000762", "pmid": "34091550", "labels": {"Type: Journal article": null, "Category: Health": null, "Research Area: Vaccine": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "00130832-900000000-98999"}], "notes": [], "created": "2021-06-07T14:06:39.950Z", "modified": "2021-12-06T12:28:38.925Z"}, {"entity": "publication", "iuid": "6c24155fe1c44fd0922da41e251baba7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c24155fe1c44fd0922da41e251baba7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c24155fe1c44fd0922da41e251baba7"}}, "title": "Schools do not need to close to reduce COVID\u201019 but other measures are advisable", "authors": [{"family": "Axelsson", "given": "Inge", "initials": "I"}], "type": "journal-article", "published": "2021-06-04", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1111/apa.15951", "pmid": null, "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-06-07T05:46:39.495Z", "modified": "2021-06-07T05:46:39.501Z"}, {"entity": "publication", "iuid": "a6ea0fe07eec4c6d918ce3abedc7e950", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6ea0fe07eec4c6d918ce3abedc7e950.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6ea0fe07eec4c6d918ce3abedc7e950"}}, "title": "Rapid and Sensitive Detection of SARS-CoV-2 Infection Using Quantitative Peptide Enrichment LC-MS/MS Analysis", "authors": [{"family": "Hober", "given": "Andreas", "initials": "A"}, {"family": "Hua", "given": "Tran Minh Khue", "initials": "TMK"}, {"family": "Foley", "given": "Dominic", "initials": "D"}, {"family": "McDonald", "given": "Thomas", "initials": "T"}, {"family": "Vissers", "given": "Johannes P C", "initials": "JPC"}, {"family": "Pattison", "given": "Rebecca", "initials": "R"}, {"family": "Ferries", "given": "Samantha", "initials": "S"}, {"family": "Hermansson", "given": "Sigurd", "initials": "S"}, {"family": "Betner", "given": "Ingvar", "initials": "I"}, {"family": "Uhlen", "given": "Mathias", "initials": "M"}, {"family": "Razavi", "given": "Morteza", "initials": "M"}, {"family": "Yip", "given": "Richard", "initials": "R"}, {"family": "Pope", "given": "Matthew E", "initials": "ME"}, {"family": "Pearson", "given": "Terry W", "initials": "TW"}, {"family": "Anderson", "given": "N Leigh", "initials": "NL"}, {"family": "Bartlett", "given": "Amy", "initials": "A"}, {"family": "Calton", "given": "Lisa", "initials": "L"}, {"family": "Alm", "given": "Jessica J", "initials": "JJ"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Edfors", "given": "Fredrik", "initials": "F"}], "type": "posted-content", "published": "2021-06-04", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.06.02.21258097", "pmid": null, "labels": {"Type: Preprint": null, "Category: Imaging": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-06-09T10:38:27.339Z", "modified": "2021-06-18T09:12:42.452Z"}, {"entity": "publication", "iuid": "dc71c9532399475e89ef881d1800a4ec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dc71c9532399475e89ef881d1800a4ec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dc71c9532399475e89ef881d1800a4ec"}}, "title": "Plasma ACE2 predicts outcome of COVID-19 in hospitalized patients.", "authors": [{"family": "Kragstrup", "given": "Tue W", "initials": "TW"}, {"family": "Singh", "given": "Helene S\u00f8gaard", "initials": "HS"}, {"family": "Grundberg", "given": "Ida", "initials": "I"}, {"family": "Nielsen", "given": "Ane Langkilde-Lauesen", "initials": "AL"}, {"family": "Rivellese", "given": "Felice", "initials": "F"}, {"family": "Mehta", "given": "Arnav", "initials": "A"}, {"family": "Goldberg", "given": "Marcia B", "initials": "MB"}, {"family": "Filbin", "given": "Michael R", "initials": "MR"}, {"family": "Qvist", "given": "Per", "initials": "P"}, {"family": "Bibby", "given": "Bo Martin", "initials": "BM"}], "type": "journal article", "published": "2021-06-04", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "6", "pages": "e0252799"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin converting enzyme 2 (ACE2) enabling entrance of the virus into cells and causing the infection termed coronavirus disease of 2019 (COVID-19). Here, we investigate associations between plasma ACE2 and outcome of COVID-19.\r\n\r\nThis analysis used data from a large longitudinal study of 306 COVID-19 positive patients and 78 COVID-19 negative patients (MGH Emergency Department COVID-19 Cohort). Comprehensive clinical data were collected on this cohort, including 28-day outcomes. The samples were run on the Olink\u00ae Explore 1536 platform which includes measurement of the ACE2 protein. High admission plasma ACE2 in COVID-19 patients was associated with increased maximal illness severity within 28 days with OR = 1.8, 95%-CI: 1.4-2.3 (P < 0.0001). Plasma ACE2 was significantly higher in COVID-19 patients with hypertension compared with patients without hypertension (P = 0.0045). Circulating ACE2 was also significantly higher in COVID-19 patients with pre-existing heart conditions and kidney disease compared with patients without these pre-existing conditions (P = 0.0363 and P = 0.0303, respectively).\r\n\r\nThis study suggests that measuring plasma ACE2 is potentially valuable in predicting COVID-19 outcomes. Further, ACE2 could be a link between COVID-19 illness severity and its established risk factors hypertension, pre-existing heart disease and pre-existing kidney disease.", "doi": "10.1371/journal.pone.0252799", "pmid": "34086837", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-06434"}], "notes": [], "created": "2021-06-08T08:37:57.861Z", "modified": "2021-06-08T08:38:14.665Z"}, {"entity": "publication", "iuid": "d4851cb729ba4249b06c14b4894c8394", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4851cb729ba4249b06c14b4894c8394.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4851cb729ba4249b06c14b4894c8394"}}, "title": "Characterization of dysphagia and laryngeal findings in COVID-19 patients treated in the ICU-An observational clinical study.", "authors": [{"family": "Osbeck Sandblom", "given": "Hanna", "initials": "H"}, {"family": "Dotevall", "given": "Hans", "initials": "H"}, {"family": "Svennerholm", "given": "Kristina", "initials": "K"}, {"family": "Tuomi", "given": "Lisa", "initials": "L"}, {"family": "Finizia", "given": "Caterina", "initials": "C"}], "type": "journal article", "published": "2021-06-04", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "6", "pages": "e0252347"}, "abstract": "Dysphagia appears to be common in patients with severe COVID-19. Information about the characteristics of dysphagia and laryngeal findings in COVID-19 patients treated in the intensive care unit (ICU) is still limited.\r\n\r\nThe aim of this study was to evaluate oropharyngeal swallowing function and laryngeal appearance and function in patients with severe COVID-19.\r\n\r\nA series of 25 ICU patients with COVID-19 and signs of dysphagia were examined with fiberendoscopic evaluation of swallowing (FEES) during the latter stage of ICU care or after discharge from the ICU. Swallowing function and laryngeal findings were assessed with standard rating scales from video recordings.\r\n\r\nPooling of secretions was found in 92% of patients. Eleven patients (44%) showed signs of silent aspiration to the trachea on at least one occasion. All patients showed residue after swallowing to some degree both in the vallecula and hypopharynx. Seventy-six percent of patients had impaired vocal cord movement. Erythema of the vocal folds was found in 60% of patients and edema in the arytenoid region in 60%.\r\n\r\nImpairment of oropharyngeal swallowing function and abnormal laryngeal findings were common in this series of patients with severe COVID-19 treated in the ICU. To avoid complications related to dysphagia in this patient group, it seems to be of great importance to evaluate the swallowing function as a standard procedure, preferably at an early stage, before initiation of oral intake. Fiberendoscopic evaluation of swallowing is preferred due to the high incidence of pooling of secretion in the hypopharynx, silent aspiration, and residuals. Further studies of the impact on swallowing function in short- and long-term in patients with COVID-19 are warranted.", "doi": "10.1371/journal.pone.0252347", "pmid": "34086717", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-05126"}], "notes": [], "created": "2021-06-08T08:38:49.661Z", "modified": "2021-06-08T08:39:11.061Z"}, {"entity": "publication", "iuid": "a7a8f3f6520a4ac7979f9f30261eb800", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7a8f3f6520a4ac7979f9f30261eb800.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7a8f3f6520a4ac7979f9f30261eb800"}}, "title": "Changes in daily life and wellbeing in adults, 70 years and older, in the beginning of the COVID-19 pandemic", "authors": [{"family": "Fristedt", "given": "Sofi", "initials": "S"}, {"family": "Carlsson", "given": "Gunilla", "initials": "G"}, {"family": "Kyl\u00e9n", "given": "Maya", "initials": "M"}, {"family": "Jonsson", "given": "Oskar", "initials": "O"}, {"family": "Granbom", "given": "Marianne", "initials": "M"}], "type": "journal-article", "published": "2021-06-04", "journal": {"title": "Scandinavian Journal of Occupational Therapy", "issn": "1103-8128", "issn-l": null, "volume": null, "issue": null, "pages": "1-11"}, "abstract": null, "doi": "10.1080/11038128.2021.1933171", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-08T08:42:45.724Z", "modified": "2021-07-14T09:19:04.290Z"}, {"entity": "publication", "iuid": "91ebcee90c8b4fefa612a55ae006431e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/91ebcee90c8b4fefa612a55ae006431e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/91ebcee90c8b4fefa612a55ae006431e"}}, "title": "Sweden's coronavirus strategy: The Public Health Agency and the sites of controversy.", "authors": [{"family": "Pashakhanlou", "given": "Arash Heydarian", "initials": "AH", "orcid": "0000-0002-5451-298X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d282433a84da4177a3b91e6529f929c8.json"}}], "type": "journal article", "published": "2021-06-03", "journal": {"title": "World Med Health Policy", "issn": "2153-2028", "issn-l": null}, "abstract": "In contrast to the vast majority of Western countries, Sweden left large segments of the society open instead of imposing a lockdown to combat the spread of the coronavirus. As a result, the Swedish COVID-19 measures, largely devised by its expert agency on health, garnered widespread international attention. Despite the global interest in the corona strategy of the Public Health Agency of Sweden (PHAS), there are currently no systematic studies on their COVID-19 policy. The present investigation focuses on the controversies that have characterized PHAS' work with reference to risk assessments, facemasks, voluntarism, testing, and the protection of the elderly during the pandemic. Overall, this inquiry demonstrates that PHAS' risk assessments were initially overly optimistic and their facemask recommendations in conflict with large segments of the scientific community for an extensive period. Yet, their voluntary measures worked moderately well. In their testing, PHAS did not manage to deliver on their promises in time, whereas several measures implemented to protect the elderly were deemed inadequate and late.", "doi": "10.1002/wmh3.449", "pmid": "34226854", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "WMH3449"}, {"db": "pmc", "key": "PMC8242624"}], "notes": [], "created": "2021-08-06T08:41:14.004Z", "modified": "2021-08-06T08:41:14.062Z"}, {"entity": "publication", "iuid": "76bb2203fc7645e5aeeef5beca15a690", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76bb2203fc7645e5aeeef5beca15a690.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76bb2203fc7645e5aeeef5beca15a690"}}, "title": "Abrupt termination of the 2019/20 influenza season following preventive measures against COVID-19 in Denmark, Norway and Sweden", "authors": [{"family": "Emborg", "given": "Hanne Dorthe", "initials": "HD"}, {"family": "Carnahan", "given": "AnnaSara", "initials": "A"}, {"family": "Bragstad", "given": "Karoline", "initials": "K"}, {"family": "Trebbien", "given": "Ramona", "initials": "R"}, {"family": "Brytting", "given": "Mia", "initials": "M"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "Bystr\u00f6m", "given": "Emma", "initials": "E"}, {"family": "Vestergaard", "given": "Lasse S", "initials": "LS"}], "type": "journal-article", "published": "2021-06-03", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "22", "pages": null}, "abstract": null, "doi": "10.2807/1560-7917.es.2021.26.22.2001160", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-07T05:45:38.163Z", "modified": "2021-07-14T09:16:46.478Z"}, {"entity": "publication", "iuid": "60d0fffeda024af68146b7ddfb088951", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60d0fffeda024af68146b7ddfb088951.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60d0fffeda024af68146b7ddfb088951"}}, "title": "Symptoms of Depression and Anxiety During the Early Phase of the COVID-19 Pandemic in Sweden.", "authors": [{"family": "Rondung", "given": "Elisabet", "initials": "E"}, {"family": "Leiler", "given": "Anna", "initials": "A"}, {"family": "Meurling", "given": "Jennifer", "initials": "J"}, {"family": "Bj\u00e4rt\u00e5", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-06-02", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "562437", "issn-l": "2296-2565"}, "abstract": "In this cross-sectional study we aimed to assess symptoms of depression and anxiety at an early stage of the COVID-19 pandemic, and to explore factors predictive of these mental health outcomes. A sample of 1,503 participants, recruited from the general Swedish population, completed an online survey distributed through social media. In this sample, 22.2% reported clinically significant levels of depressive symptoms (PHQ-9 \u2265 10) and 10.9% indicated possible major depression using the PHQ-9 algorithm. Moreover, 28.3% reported clinically significant levels of anxiety (GAD-7 \u2265 8) and 9.7% severe anxiety and possible GAD (GAD-7 \u2265 15). Multiple linear regression analyses identified some common predictors for both outcomes. Age, having a stable income, and sufficient social stimulation, sleep, and recovery showed negative associations, whereas worry about the economy and overall burden showed positive associations. These results suggest an impact on mental health already at an early stage of the COVID-19 pandemic.", "doi": "10.3389/fpubh.2021.562437", "pmid": "34150691", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8206505"}], "notes": [], "created": "2021-06-28T18:23:49.877Z", "modified": "2023-01-13T14:44:35.901Z"}, {"entity": "publication", "iuid": "c3b94717e04649e1b6097a9f0472e679", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3b94717e04649e1b6097a9f0472e679.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3b94717e04649e1b6097a9f0472e679"}}, "title": "SARS-CoV-2 in hospital indoor environments is predominantly non-infectious.", "authors": [{"family": "Krambrich", "given": "Janina", "initials": "J"}, {"family": "Akaberi", "given": "Dario", "initials": "D"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Svensson", "given": "Lennart", "initials": "L"}, {"family": "Hagbom", "given": "Marie", "initials": "M"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "journal article", "published": "2021-06-02", "journal": {"title": "Virol J", "issn": "1743-422X", "issn-l": null, "volume": "18", "issue": "1", "pages": "109"}, "abstract": "The ongoing SARS-CoV-2 pandemic has spread rapidly worldwide and disease prevention is more important than ever. In the absence of a vaccine, knowledge of the transmission routes and risk areas of infection remain the most important existing tools to prevent further spread.\r\n\r\nHere we investigated the presence of the SARS-CoV-2 virus in the hospital environment at the Uppsala University Hospital Infectious Disease ward by RT-qPCR and determined the infectivity of the detected virus in vitro on Vero E6 cells.\r\n\r\nSARS-CoV-2 RNA was detected in several areas, although attempts to infect Vero E6 cells with positive samples were unsuccessful. However, RNase A treatment of positive samples prior to RNA extraction did not degrade viral RNA, indicating the presence of SARS-CoV-2 nucleocapsids or complete virus particles protecting the RNA as opposed to free viral RNA.\r\n\r\nOur results show that even in places where a moderate concentration (Ct values between 30 and 38) of SARS-CoV-2 RNA was found; no infectious virus could be detected. This suggests that the SARS-CoV-2 virus in the hospital environment subsides in two states; as infectious and as non-infectious. Future work should investigate the reasons for the non-infectivity of SARS-CoV-2 virions.", "doi": "10.1186/s12985-021-01556-6", "pmid": "34078386", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Category: Health": null, "Research Area: High-throughput and high-content serology": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12985-021-01556-6"}, {"db": "URL", "key": "https://static-content.springer.com/esm/art%3A10.1186%2Fs12985-021-01556-6/MediaObjects/12985_2021_1556_MOESM1_ESM.pdf", "description": "Ct values for all collected samples at the Uppsala University infectious disease ward"}], "notes": [], "created": "2021-06-04T11:04:45.124Z", "modified": "2021-08-25T08:17:42.781Z"}, {"entity": "publication", "iuid": "46e6889db97c4af2be73b1e55efe3b6d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46e6889db97c4af2be73b1e55efe3b6d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46e6889db97c4af2be73b1e55efe3b6d"}}, "title": "Point of care ultrasound screening for deep vein thrombosis in critically ill COVID-19 patients, an observational study.", "authors": [{"family": "Galien", "given": "Sarah", "initials": "S"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Stattin", "given": "Karl", "initials": "K"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Ros\u00e9n", "given": "Jacob", "initials": "J"}, {"family": "Uppsala Intensive Care COVID-19 Research Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-06-02", "journal": {"title": "Thromb J", "issn": "1477-9560", "issn-l": null, "volume": "19", "issue": "1", "pages": "38"}, "abstract": "Deep vein thrombosis (DVT) is common in critically ill patients with Coronavirus disease 2019 (COVID-19) and may cause fatal pulmonary embolism (PE) prior to diagnosis due to subtle clinical symptoms. The aim of this study was to explore the feasibility of bedside screening for DVT in critically ill COVID-19 patients performed by physicians with limited experience of venous ultrasound. We further aimed to compare inflammation, coagulation and organ dysfunction in patients with and without venous thromboembolism (VTE).\r\n\r\nThis observational study included patients with COVID-19 admitted to the intensive care unit (ICU) of a tertiary hospital in Sweden and screened for DVT with proximal compression ultrasound of the lower extremities between April and July 2020. Screening was performed by ICU residents having received a short online education and one hands-on-session. Pathological screening ultrasound was confirmed by formal ultrasound whereas patients with negative screening underwent formal ultrasound on clinical suspicion. Clinical data, laboratory findings and follow-up were extracted from medical records.\r\n\r\nOf 90 eligible patients, 56 were screened by seven ICU residents with no (n = 5) or limited (n = 2) previous experience of DVT ultrasound who performed a median of 4 (IQR 2-19) examinations. Four (7.1%) patients had pathological screening ultrasound of which three (5.6%) were confirmed by formal ultrasound. None of the 52 patients with negative screening ultrasound were diagnosed with DVT during follow-up. Six patients were diagnosed with PE of which four prior to negative screening and two following negative and positive screening respectively. Patients with VTE (n = 8) had higher median peak D-dimer (24.0 (IQR 14.2-50.5) vs. 2.8 (IQR 1.7-7.2) mg/L, p = 0.004), mean peak C-reactive protein (363 (SD 80) vs. 285 (SD 108) mg/L, p = 0.033) and median peak plasma creatinine (288 (IQR 131-328) vs. 94 (IQR 78-131) \u03bcmol/L, p = 0.009) compared to patients without VTE (n = 48). Five patients (63%) with VTE received continuous renal replacement therapy compared to six patients (13%) without VTE (p = 0.005).\r\n\r\nICU residents with no or limited experience could detect DVT with ultrasound in critically ill COVID-19 patients following a short education. VTE was associated with kidney dysfunction and features of hyperinflammation and hypercoagulation.\r\n\r\nClinicalTrials ID: NCT04316884 . Registered 20 March 2020.", "doi": "10.1186/s12959-021-00272-z", "pmid": "34078399", "labels": {"Type: Journal article": null, "Category: Health": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12959-021-00272-z"}, {"db": "ClinicalTrials.gov", "key": "NCT04316884"}, {"db": "URL", "key": "https://doi.org/10.17044/scilifelab.14229410.v1", "description": "Metadata record"}], "notes": [], "created": "2021-06-04T10:55:06.564Z", "modified": "2021-06-21T14:44:24.986Z"}, {"entity": "publication", "iuid": "c8641609df574656ac6e2104bcdc7fe6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c8641609df574656ac6e2104bcdc7fe6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c8641609df574656ac6e2104bcdc7fe6"}}, "title": "COVID-19 and stem cell transplantation; results from an EBMT and GETH multicenter prospective survey.", "authors": [{"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "de la Camara", "given": "Rafael", "initials": "R"}, {"family": "Mikulska", "given": "Malgorzata", "initials": "M"}, {"family": "Tridello", "given": "Gloria", "initials": "G"}, {"family": "Aguado", "given": "Beatriz", "initials": "B"}, {"family": "Zahrani", "given": "Mohsen Al", "initials": "MA"}, {"family": "Apperley", "given": "Jane", "initials": "J"}, {"family": "Berceanu", "given": "Ana", "initials": "A"}, {"family": "Bofarull", "given": "Rodrigo Martino", "initials": "RM"}, {"family": "Calbacho", "given": "Maria", "initials": "M"}, {"family": "Ciceri", "given": "Fabio", "initials": "F"}, {"family": "Lopez-Corral", "given": "Lucia", "initials": "L"}, {"family": "Crippa", "given": "Claudia", "initials": "C"}, {"family": "Fox", "given": "Maria Laura", "initials": "ML"}, {"family": "Grassi", "given": "Anna", "initials": "A"}, {"family": "Jimenez", "given": "Maria-Jose", "initials": "MJ"}, {"family": "Demir", "given": "Safiye Ko\u00e7ulu", "initials": "SK"}, {"family": "Kwon", "given": "Mi", "initials": "M"}, {"family": "Llamas", "given": "Carlos Vallejo", "initials": "CV"}, {"family": "Lorenzo", "given": "Jos\u00e9 Luis L\u00f3pez", "initials": "JLL"}, {"family": "Mielke", "given": "Stephan", "initials": "S"}, {"family": "Orchard", "given": "Kim", "initials": "K"}, {"family": "Porras", "given": "Rocio Parody", "initials": "RP"}, {"family": "Vallisa", "given": "Daniele", "initials": "D"}, {"family": "Xhaard", "given": "Alienor", "initials": "A"}, {"family": "Knelange", "given": "Nina Simone", "initials": "NS"}, {"family": "Cedillo", "given": "Angel", "initials": "A"}, {"family": "Kr\u00f6ger", "given": "Nicolaus", "initials": "N"}, {"family": "Pi\u00f1ana", "given": "Jos\u00e9 Luis", "initials": "JL"}, {"family": "Styczynski", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2021-06-02", "journal": {"title": "Leukemia", "issn": "1476-5551", "volume": null, "issue": null, "issn-l": null}, "abstract": "This study reports on 382 COVID-19 patients having undergone allogeneic (n = 236) or autologous (n = 146) hematopoietic cell transplantation (HCT) reported to the European Society for Blood and Marrow Transplantation (EBMT) or to the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH). The median age was 54.1 years (1.0-80.3) for allogeneic, and 60.6 years (7.7-81.6) for autologous HCT patients. The median time from HCT to COVID-19 was 15.8 months (0.2-292.7) in allogeneic and 24.6 months (-0.9 to 350.3) in autologous recipients. 83.5% developed lower respiratory tract disease and 22.5% were admitted to an ICU. Overall survival at 6 weeks from diagnosis was 77.9% and 72.1% in allogeneic and autologous recipients, respectively. Children had a survival of 93.4%. In multivariate analysis, older age (p = 0.02), need for ICU (p < 0.0001) and moderate/high immunodeficiency index (p = 0.04) increased the risk while better performance status (p = 0.001) decreased the risk for mortality. Other factors such as underlying diagnosis, time from HCT, GVHD, or ongoing immunosuppression did not significantly impact overall survival. We conclude that HCT patients are at high risk of developing LRTD, require admission to ICU, and have increased mortality in COVID-19.", "doi": "10.1038/s41375-021-01302-5", "pmid": "34079042", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41375-021-01302-5"}], "notes": [], "created": "2021-06-04T08:14:17.305Z", "modified": "2021-06-04T10:54:25.197Z"}, {"entity": "publication", "iuid": "a2c82a2f8756499cb454bd4e2cd18144", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2c82a2f8756499cb454bd4e2cd18144.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2c82a2f8756499cb454bd4e2cd18144"}}, "title": "A global analysis of the impact of COVID-19 stay-at-home restrictions on crime.", "authors": [{"family": "Nivette", "given": "Amy E", "initials": "AE"}, {"family": "Zahnow", "given": "Renee", "initials": "R"}, {"family": "Aguilar", "given": "Raul", "initials": "R"}, {"family": "Ahven", "given": "Andri", "initials": "A"}, {"family": "Amram", "given": "Shai", "initials": "S"}, {"family": "Ariel", "given": "Barak", "initials": "B"}, {"family": "Burbano", "given": "Mar\u00eda Jos\u00e9 Arosemena", "initials": "MJA"}, {"family": "Astolfi", "given": "Roberta", "initials": "R"}, {"family": "Baier", "given": "Dirk", "initials": "D"}, {"family": "Bark", "given": "Hyung-Min", "initials": "H"}, {"family": "Beijers", "given": "Joris E H", "initials": "JEH"}, {"family": "Bergman", "given": "Marcelo", "initials": "M"}, {"family": "Breetzke", "given": "Gregory", "initials": "G"}, {"family": "Concha-Eastman", "given": "I Alberto", "initials": "IA"}, {"family": "Curtis-Ham", "given": "Sophie", "initials": "S"}, {"family": "Davenport", "given": "Ryan", "initials": "R"}, {"family": "D\u00edaz", "given": "Carlos", "initials": "C"}, {"family": "Fleitas", "given": "Diego", "initials": "D"}, {"family": "Gerell", "given": "Manne", "initials": "M"}, {"family": "Jang", "given": "Kwang-Ho", "initials": "K"}, {"family": "K\u00e4\u00e4ri\u00e4inen", "given": "Juha", "initials": "J"}, {"family": "Lappi-Sepp\u00e4l\u00e4", "given": "Tapio", "initials": "T"}, {"family": "Lim", "given": "Woon-Sik", "initials": "W"}, {"family": "Revilla", "given": "Rosa Loureiro", "initials": "RL"}, {"family": "Mazerolle", "given": "Lorraine", "initials": "L"}, {"family": "Me\u0161ko", "given": "Gorazd", "initials": "G"}, {"family": "Pereda", "given": "Noem\u00ed", "initials": "N"}, {"family": "Peres", "given": "Maria F T", "initials": "MFT"}, {"family": "Poblete-Cazenave", "given": "Rub\u00e9n", "initials": "R"}, {"family": "Rose", "given": "Simon", "initials": "S"}, {"family": "Svensson", "given": "Robert", "initials": "R"}, {"family": "Trajtenberg", "given": "Nico", "initials": "N"}, {"family": "van der Lippe", "given": "Tanja", "initials": "T"}, {"family": "Veldkamp", "given": "Joran", "initials": "J"}, {"family": "Perdomo", "given": "Carlos J Vilalta", "initials": "CJV"}, {"family": "Eisner", "given": "Manuel P", "initials": "MP"}], "type": "journal article", "published": "2021-06-02", "journal": {"title": "Nat Hum Behav", "issn": "2397-3374", "issn-l": "2397-3374", "volume": null, "issue": null, "pages": null}, "abstract": "The stay-at-home restrictions to control the spread of COVID-19 led to unparalleled sudden change in daily life, but it is unclear how they affected urban crime globally. We collected data on daily counts of crime in 27 cities across 23 countries in the Americas, Europe, the Middle East and Asia. We conducted interrupted time series analyses to assess the impact of stay-at-home restrictions on different types of crime in each city. Our findings show that the stay-at-home policies were associated with a considerable drop in urban crime, but with substantial variation across cities and types of crime. Meta-regression results showed that more stringent restrictions over movement in public space were predictive of larger declines in crime.", "doi": "10.1038/s41562-021-01139-z", "pmid": "34079096", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41562-021-01139-z"}], "notes": [], "created": "2021-06-04T11:41:59.417Z", "modified": "2022-11-23T08:59:40.855Z"}, {"entity": "publication", "iuid": "59678e2f49ae4b0eaf262ea1fb91a031", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/59678e2f49ae4b0eaf262ea1fb91a031.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/59678e2f49ae4b0eaf262ea1fb91a031"}}, "title": "Electrolyte and acid-base imbalance in severe COVID-19.", "authors": [{"family": "Sj\u00f6str\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Rysz", "given": "Susanne", "initials": "S"}, {"family": "Sj\u00f6str\u00f6m", "given": "Henrik", "initials": "H"}, {"family": "H\u00f6ybye", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2021-06-01", "journal": {"title": "Endocr Connect", "issn": "2049-3614", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Acute systemic diseases, such as severe infections, can lead to electrolyte and acid-base alterations. To study the presence of electrolyte imbalance in severe COVID-19, we investigated the frequency and consequences of changes in electrolyte and acid-base patterns over time. We performed a retrospective cohort study including 406 patients with severe COVID-19. Levels of electrolytes, base excess, pH, serum osmolality and hematocrit, the first two weeks of hospitalization, were collected daily from the laboratory database and clinical data from patients' medical records. We found that hyponatremia was present in 57% of the patients at admission and hypernatremia in 2%. However, within two weeks of hospitalization 42% of the patients developed hypernatremia, more frequently in critically ill patients. Lower levels of sodium and potassium at admission was associated with need of mechanical ventilation. Decreased pH at admission was associated with both death and need of mechanical ventilation. Hypernatremia in the ICU was combined with rising base excess and a higher pH. In the group without intensive care, potassium levels was significantly lower in the patients with severe hypernatremia. Presence of hypernatremia during the first two weeks of hospitalization was associated with 3.942 (95% CI 2.269-6.851) times higher odds of death. In summary, hypernatremia was common and associated with longer hospital stay and a higher risk of death, suggesting that the dynamics of sodium is an important indicator of severity in COVID-19.", "doi": "10.1530/EC-21-0265", "pmid": "34156969", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "EC-21-0265"}], "notes": [], "created": "2021-06-28T18:22:10.843Z", "modified": "2021-06-28T18:22:24.253Z"}, {"entity": "publication", "iuid": "445e48b49c1846c780e1e603c3a4769a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/445e48b49c1846c780e1e603c3a4769a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/445e48b49c1846c780e1e603c3a4769a"}}, "title": "Colloidal dispersion of poly(ionic liquid)/Cu composite particles for protective surface coating against SAR-CoV-2.", "authors": [{"family": "Khorsand Kheirabad", "given": "Atefeh", "initials": "A"}, {"family": "Pan", "given": "Xuefeng", "initials": "X"}, {"family": "Long", "given": "Siwen", "initials": "S"}, {"family": "Kochovski", "given": "Zdravko", "initials": "Z"}, {"family": "Zhou", "given": "Shiqi", "initials": "S"}, {"family": "Lu", "given": "Yan", "initials": "Y"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Yuan", "given": "Jiayin", "initials": "J"}], "type": "journal article", "published": "2021-06-01", "journal": {"title": "Nano Sel", "issn": "2688-4011", "issn-l": null}, "abstract": "Herein, we report a waterproof anti-SARS-CoV-2 protective film prepared by spray-coating of an aqueous colloidal dispersion of poly(ionic liquid)/copper (PIL/Cu) composite nanoparticles onto a substrate. The PIL dispersion was prepared by suspension polymerization of 3-dodecyl-1-vinylimdiazolium bromide in water at 70\u00b0C. The copper acetate salt was added into the PIL nanoparticle dispersion and in situ reduced into copper nanoparticles anchoring onto the PIL nanoparticles. Despite being waterborne, the PIL in bulk is intrinsically insoluble in water and the formed coating is stable in water. The formed surface coating by PIL/copper composite nanoparticles was able to deactivate SARS-CoV-2 virions by 90.0% in 30 minutes and thus may effectively prevent the spread of SARS-CoV-2 through surface contact. This method may provide waterborne dispersions for a broad range of antivirus protective surface coatings for both outdoor and indoor applications.", "doi": "10.1002/nano.202100069", "pmid": "34485979", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "NANO202100069"}, {"db": "pmc", "key": "PMC8242609"}], "notes": [], "created": "2021-09-09T05:33:55.285Z", "modified": "2021-09-09T05:34:12.458Z"}, {"entity": "publication", "iuid": "45136e9ac839441891070f8397ec88a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/45136e9ac839441891070f8397ec88a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/45136e9ac839441891070f8397ec88a0"}}, "title": "Tracheotomy in COVID-19 patients: A retrospective study on complications and timing.", "authors": [{"family": "Pauli", "given": "Nina", "initials": "N", "orcid": "0000-0002-4058-2477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42734bf19ccc426986c4c7360d467655.json"}}, {"family": "Eeg-Olofsson", "given": "M\u00e5ns", "initials": "M"}, {"family": "Bergquist", "given": "Henrik", "initials": "H"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Laryngoscope Investig Otolaryngol", "issn": "2378-8038", "volume": "6", "issue": "3", "pages": "446-452", "issn-l": null}, "abstract": "The aim of this study was to analyze the timing of tracheotomy and the duration of mechanical ventilation and stay in the intensive care unit (ICU) in patients with COVID-19 infection. Furthermore, we aimed to investigate tracheotomy complications and mortality.\n\nConsecutive patients with COVID-19 infection admitted to the Department of Infectious Diseases in Gothenburg, Sweden were identified. Medical records were retrieved and retrospectively assessed.\n\nOne hundred eighty-eight patients with COVID-19 infection requiring hospital care were identified. Of these, 116 patients were critically ill and intubated, and 55 patients underwent tracheotomy. The mean time from endotracheal intubation to tracheotomy was 12 days (range 5-28 days). There was a correlation between the timing of tracheotomy and the duration of mechanical ventilation, where a shorter time between intubation and tracheotomy was correlated with a shorter duration of mechanical ventilation (r .58, P < .001), and a correlation was identified between the timing of tracheotomy and the duration of ICU stay (r .52, P < .001). Perioperative hypoxemia was registered in 9% of tracheotomies performed, whereas postoperative bleeding was observed in 27% of cases, the majority of which were minor.\n\nThis retrospective cohort study indicates that early tracheotomy is related to a reduced need for mechanical ventilation and a shorter duration of stay in the ICU in severe cases of COVID-19 disease. Complications during and after tracheotomy in this specific cohort included risk perioperative hypoxia and postoperative bleeding. Prospective randomized controlled trials would be of value to confirm these findings.\n\n4, Case series.", "doi": "10.1002/lio2.560", "pmid": "34195366", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "LIO2560"}, {"db": "pmc", "key": "PMC8223451"}], "notes": [], "created": "2021-07-05T14:30:43.050Z", "modified": "2021-07-05T14:30:43.104Z"}, {"entity": "publication", "iuid": "e851543e1e4e4893aeb160d7e7db8ac5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e851543e1e4e4893aeb160d7e7db8ac5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e851543e1e4e4893aeb160d7e7db8ac5"}}, "title": "Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study.", "authors": [{"family": "COVIDSurg Collaborative", "given": "", "initials": ""}, {"family": "GlobalSurg Collaborative", "given": "", "initials": ""}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Anaesthesia", "issn": "1365-2044", "issn-l": "0003-2409", "volume": "76", "issue": "6", "pages": "748-758"}, "abstract": "Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre-operative SARS-CoV-2 infection were compared with those without previous SARS-CoV-2 infection. The primary outcome measure was 30-day postoperative mortality. Logistic regression models were used to calculate adjusted 30-day mortality rates stratified by time from diagnosis of SARS-CoV-2 infection to surgery. Among 140,231 patients (116 countries), 3127 patients (2.2%) had a pre-operative SARS-CoV-2 diagnosis. Adjusted 30-day mortality in patients without SARS-CoV-2 infection was 1.5% (95%CI 1.4-1.5). In patients with a pre-operative SARS-CoV-2 diagnosis, mortality was increased in patients having surgery within 0-2 weeks, 3-4 weeks and 5-6 weeks of the diagnosis (odds ratio (95%CI) 4.1 (3.3-4.8), 3.9 (2.6-5.1) and 3.6 (2.0-5.2), respectively). Surgery performed \u2265 7 weeks after SARS-CoV-2 diagnosis was associated with a similar mortality risk to baseline (odds ratio (95%CI) 1.5 (0.9-2.1)). After a \u2265 7 week delay in undertaking surgery following SARS-CoV-2 infection, patients with ongoing symptoms had a higher mortality than patients whose symptoms had resolved or who had been asymptomatic (6.0% (95%CI 3.2-8.7) vs. 2.4% (95%CI 1.4-3.4) vs. 1.3% (95%CI 0.6-2.0), respectively). Where possible, surgery should be delayed for at least 7 weeks following SARS-CoV-2 infection. Patients with ongoing symptoms \u2265 7 weeks from diagnosis may benefit from further delay.", "doi": "10.1111/anae.15458", "pmid": "33690889", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8206995"}], "notes": [], "created": "2021-03-17T12:29:40.454Z", "modified": "2023-06-19T15:14:42.544Z"}, {"entity": "publication", "iuid": "e1d3160ba88043cb8f709061c798b507", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e1d3160ba88043cb8f709061c798b507.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e1d3160ba88043cb8f709061c798b507"}}, "title": "The impact of COVID-19 pandemic on vascular registries and clinical trials.", "authors": [{"family": "Aziz", "given": "Faisal", "initials": "F"}, {"family": "Behrendt", "given": "Christian-Alexander", "initials": "CA"}, {"family": "Sullivan", "given": "Kaity", "initials": "K"}, {"family": "Beck", "given": "Adam W", "initials": "AW"}, {"family": "Beiles", "given": "C Barry", "initials": "CB"}, {"family": "Boyle", "given": "Jon R", "initials": "JR"}, {"family": "Mani", "given": "Kevin", "initials": "K"}, {"family": "Benson", "given": "Ruth A", "initials": "RA"}, {"family": "Wohlauer", "given": "Max V", "initials": "MV"}, {"family": "Khashram", "given": "Manar", "initials": "M"}, {"family": "Jorgensen", "given": "Jens Eldrup", "initials": "JE"}, {"family": "Lemmon", "given": "Gary W", "initials": "GW"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Semin Vasc Surg", "issn": "1558-4518", "volume": "34", "issue": "2", "pages": "28-36", "issn-l": null}, "abstract": "Quality improvement programs and clinical trial research experienced disruption due to the coronavirus disease 2019 (COVID-19) pandemic. Vascular registries showed an immediate impact with significant declines in second-quarter vascular procedure volumes witnessed across Europe and the United States. To better understand the magnitude and impact of the pandemic, organizations and study groups sent grass roots surveys to vascular specialists for needs assessment. Several vascular registries responded quickly by insertion of COVID-19 variables into their data collection forms. More than 80% of clinical trials have been reported delayed or not started due to factors that included loss of enrollment from patient concerns or mandated institutional shutdowns, weighing the risk of trial participation on patient safety. Preliminary data of patients undergoing vascular surgery with active COVID-19 infection show inferior outcomes (morbidity) and increased mortality. Disease-specific vascular surgery study collaboratives about COVID-19 were created for the desire to study the disease in a more focused manner than possible through registry outcomes. This review describes the pandemic effect on multiple VASCUNET registries including Germany (GermanVasc), Sweden (SwedVasc), United Kingdom (UK National Vascular Registry), Australia and New Zealand (bi-national Australasian Vascular Audit), as well as the United States (Society for Vascular Surgery Vascular Quality Initiative). We will highlight the continued collaboration of VASCUNET with the Vascular Quality Initiative in the International Consortium of Vascular Registries as part of the Medical Device Epidemiology Network coordinated registry network. Vascular registries must remain flexible and responsive to new and future real-world problems affecting vascular patients.", "doi": "10.1053/j.semvascsurg.2021.04.001", "pmid": "34144744", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0895-7967(21)00025-9"}, {"db": "pmc", "key": "PMC8137351"}], "notes": [], "created": "2021-06-28T18:29:11.034Z", "modified": "2021-06-28T18:29:11.056Z"}, {"entity": "publication", "iuid": "0ce9c878343748629bbc7bda9bcda93a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ce9c878343748629bbc7bda9bcda93a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ce9c878343748629bbc7bda9bcda93a"}}, "title": "The impact of COVID-19 lockdown on dengue transmission in Sri Lanka; A natural experiment for understanding the influence of human mobility.", "authors": [{"family": "Liyanage", "given": "Prasad", "initials": "P", "orcid": "0000-0002-5174-7644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bee7bfe3b6e2476b8337f0c22925a874.json"}}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J", "orcid": "0000-0003-4030-0449", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5f15a200e614e10a8d972285750e745.json"}}, {"family": "Tissera", "given": "Hasitha Aravinda", "initials": "HA", "orcid": "0000-0002-9379-1002", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8bcd2f470e2f4dfcb5bbd2a1b8b50b26.json"}}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "PLoS Negl Trop Dis", "issn": "1935-2735", "issn-l": null, "volume": "15", "issue": "6", "pages": "e0009420"}, "abstract": "Dengue is one of the major public health problems in Sri Lanka. Its outbreak pattern depends on a multitude of drivers, including human mobility. Here we evaluate the impact of COVID-19 related mobility restriction (lockdown) on the risk of dengue in Sri Lanka.\n\nTwo-stage hierarchical models were fitted using an interrupted time-series design based on the notified dengue cases, January 2015 to July 2020. In the first stage model, the district level impact was estimated using quasi-Poisson regression models while accounting for temporal trends. Estimates were pooled at zonal and national levels in the second stage model using meta-analysis. The influence of the extended period of school closure on dengue in children in the western province was compared to adults.\n\nStatistically significant and homogeneous reduction of dengue risk was observed at all levels during the lockdown. Overall an 88% reduction in risk (RR 0.12; 95% CI from 0.08 to 0.17) was observed at the national level. The highest impact was observed among children aged less than 19 years showing a 92% reduction (RR 0.8; 95% CI from 0.03 to 0.25). We observed higher impact in the dry zone having 91% reduction (RR 0.09; 95% CI from 0.05 to 0.15) compared to wet zone showing 83% reduction (RR 0.17; 95% CI from 0.09 to 0.30). There was no indication that the overall health-seeking behaviour for dengue had a substantial influence on these estimates.\n\nThis study offers a broad understanding of the change in risk of dengue during the COVID-19 pandemic and associated mobility restrictions in Sri Lanka. The analysis using the mobility restrictions as a natural experiment suggests mobility patterns to be a very important driver of dengue transmission.", "doi": "10.1371/journal.pntd.0009420", "pmid": "34111117", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8192006"}, {"db": "pii", "key": "PNTD-D-20-02142"}], "notes": [], "created": "2021-06-11T05:04:37.672Z", "modified": "2023-06-19T15:04:40.021Z"}, {"entity": "publication", "iuid": "153dd3f5eadd46babafb9997a4ebe1ba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/153dd3f5eadd46babafb9997a4ebe1ba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/153dd3f5eadd46babafb9997a4ebe1ba"}}, "title": "The SIOG COVID-19 working group recommendations on the rollout of COVID-19 vaccines among older adults with cancer.", "authors": [{"family": "Mislang", "given": "Anna Rachelle", "initials": "AR"}, {"family": "Soto-Perez-de-Celis", "given": "Enrique", "initials": "E"}, {"family": "Russo", "given": "Chiara", "initials": "C"}, {"family": "Colloca", "given": "Giuseppe", "initials": "G"}, {"family": "Williams", "given": "Grant R", "initials": "GR"}, {"family": "O'Hanlon", "given": "Shane", "initials": "S"}, {"family": "Cooper", "given": "Lisa", "initials": "L"}, {"family": "O'Donovan", "given": "Anita", "initials": "A"}, {"family": "Audisio", "given": "Riccardo A", "initials": "RA"}, {"family": "Cheung", "given": "Kwok-Leung", "initials": "KL"}, {"family": "Sarri\u00f3", "given": "Regina Giron\u00e9s", "initials": "RG"}, {"family": "Stauder", "given": "Reinhard", "initials": "R"}, {"family": "Jaklitsch", "given": "Michael", "initials": "M"}, {"family": "Cairo", "given": "Clarito", "initials": "C"}, {"family": "Gil", "given": "Luiz Antonio", "initials": "LA"}, {"family": "Sattar", "given": "Schroder", "initials": "S"}, {"family": "Kantilal", "given": "Kumud", "initials": "K"}, {"family": "Loh", "given": "Kah Poh", "initials": "KP"}, {"family": "Lichtman", "given": "Stuart M", "initials": "SM"}, {"family": "Brain", "given": "Etienne", "initials": "E"}, {"family": "Wildiers", "given": "Hans", "initials": "H"}, {"family": "Kanesvaran", "given": "Ravindran", "initials": "R"}, {"family": "Battisti", "given": "Nicol\u00f2 Matteo Luca", "initials": "NML"}], "type": "letter", "published": "2021-06-00", "journal": {"title": "J Geriatr Oncol", "issn": "1879-4076", "volume": "12", "issue": "5", "pages": "848-850", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jgo.2021.03.003", "pmid": "33715995", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1879-4068(21)00057-6"}, {"db": "pmc", "key": "PMC7934668"}], "notes": [], "created": "2021-03-17T07:13:04.746Z", "modified": "2021-11-18T12:48:50.459Z"}, {"entity": "publication", "iuid": "cb5b53f903dd43ac81c6315419c96fe0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cb5b53f903dd43ac81c6315419c96fe0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cb5b53f903dd43ac81c6315419c96fe0"}}, "title": "The New Totalitarians: The Swedish COVID-19 strategy and the implications of consensus culture and media policy for public health.", "authors": [{"family": "Lindstr\u00f6m", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "SSM Popul Health", "issn": "2352-8273", "issn-l": null, "volume": "14", "issue": null, "pages": "100788"}, "abstract": "The aim is to discuss implications of consensus culture in combination with media policy in Sweden with regard to the Swedish COVID-19 strategy in the spring of 2020.\r\n\r\nInvestigation of prerequisites for scrutiny by the Swedish mass media of the Swedish strategy in the spring of 2020 based on discussion regarding consensus culture, media structure and postmodernism in science, politics and administration.\r\n\r\nThe Swedish strategy entailed strong initial confidence in herd immunity (although not officially stated), individual responsibility, evidence based medicine and substantial neglect to cooperate internationally. The strategy may be regarded partly as a result of the postmodern view of science and society predominant in Sweden. A tradition of top down consensus culture combined with mass media's financial and partly structural dependence of the state may help explain the comparative lack of critical questions regarding the strategy at the press conferences in the spring of 2020.\r\n\r\nMass media in Sweden should become more financially and structurally independent of the state. The reporting by Swedish media in the spring of 2020 should be subject to peer-reviewed research.", "doi": "10.1016/j.ssmph.2021.100788", "pmid": "34136630", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2352-8273(21)00063-X"}, {"db": "pmc", "key": "PMC8182112"}], "notes": [], "created": "2021-06-28T18:41:53.111Z", "modified": "2021-07-14T09:09:06.291Z"}, {"entity": "publication", "iuid": "db4f6196f40a4023837567fb80842949", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db4f6196f40a4023837567fb80842949.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db4f6196f40a4023837567fb80842949"}}, "title": "T cell immunity to SARS-CoV-2.", "authors": [{"family": "Niessl", "given": "Julia", "initials": "J"}, {"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Semin Immunol", "issn": "1096-3618", "pages": "101505", "volume": "55", "issn-l": null}, "abstract": "Exceptional efforts have been undertaken to shed light into the biology of adaptive immune responses to SARS-CoV-2. T cells occupy a central role in adaptive immunity to mediate helper functions to different arms of the immune system and are fundamental to mediate protection, control, and clearance of most viral infections. Even though many questions remain unsolved, there is a growing literature linking specific T cell characteristics to differential COVID-19 severity and vaccine outcome. In this review, we summarize our current understanding of CD4+ and CD8+ T cell responses in acute and convalescent COVID-19. Further, we discuss the T cell literature coupled to pre-existing immunity and vaccines and highlight the need to look beyond blood to fully understand how T cells function in the tissue space.", "doi": "10.1016/j.smim.2021.101505", "pmid": "34711489", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8529278"}, {"db": "pii", "key": "S1044-5323(21)00036-1"}], "notes": [], "created": "2021-11-01T19:51:00.402Z", "modified": "2023-01-13T13:25:49.721Z"}, {"entity": "publication", "iuid": "63d6d2d5319f47f4894f5efeed7eef39", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63d6d2d5319f47f4894f5efeed7eef39.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63d6d2d5319f47f4894f5efeed7eef39"}}, "title": "Sleep problems during COVID-19 pandemic and its' association to psychological distress: A systematic review and meta-analysis.", "authors": [{"family": "Alimoradi", "given": "Zainab", "initials": "Z"}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Tsang", "given": "Hector W H", "initials": "HWH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Haghayegh", "given": "Shahab", "initials": "S"}, {"family": "Ohayon", "given": "Maurice M", "initials": "MM"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "issn-l": null, "volume": "36", "issue": null, "pages": "100916"}, "abstract": "The emerging novel coronavirus disease 2019 (COVID-19) has become one of the leading cause of deaths worldwide in 2020. The present systematic review and meta-analysis estimated the magnitude of sleep problems during the COVID-19 pandemic and its relationship with psychological distress.\r\n\r\nFive academic databases ( Scopus, PubMed Central, ProQuest, ISI Web of Knowledge, and Embase) were searched. Observational studies including case-control studies and cross-sectional studies were included if relevant data relationships were reported (i.e., sleep assessed utilizing the Pittsburgh Sleep Quality Index or Insomnia Severity Index). All the studies were English, peer-reviewed papers published between December 2019 and February 2021. PROSPERO registration number: CRD42020181644.\r\n\r\n168 cross-sectional, four case-control, and five longitudinal design papers comprising 345,270 participants from 39 countries were identified. The corrected pooled estimated prevalence of sleep problems were 31% among healthcare professionals, 18% among the general population, and 57% among COVID-19 patients (all p-values < 0.05). Sleep problems were associated with depression among healthcare professionals, the general population, and COVID-19 patients, with Fisher's Z scores of -0.28, -0.30, and -0.36, respectively. Sleep problems were positively (and moderately) associated with anxiety among healthcare professionals, the general population, and COVID-19 patients, with Fisher's z scores of 0.55, 0.48, and 0.49, respectively.\r\n\r\nSleep problems appear to have been common during the ongoing COVID-19 pandemic. Moreover, sleep problems were found to be associated with higher levels of psychological distress. With the use of effective programs treating sleep problems, psychological distress may be reduced. Vice versa, the use of effective programs treating psychological distress, sleep problems may be reduced.\r\n\r\nThe present study received no funding.", "doi": "10.1016/j.eclinm.2021.100916", "pmid": "34131640", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(21)00196-6"}, {"db": "pmc", "key": "PMC8192091"}], "notes": [], "created": "2021-06-17T07:35:43.630Z", "modified": "2021-07-14T09:12:28.694Z"}, {"entity": "publication", "iuid": "fc24ed82a6ff4d4ca6ec337815354701", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc24ed82a6ff4d4ca6ec337815354701.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc24ed82a6ff4d4ca6ec337815354701"}}, "title": "Response by Mackman et al to Letter Regarding Article, \"Patients With COVID-19 Have Elevated Levels of Circulating Extracellular Vesicle Tissue Factor Activity That Is Associated With Severity and Mortality-Brief Report\".", "authors": [{"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Hisada", "given": "Yohei", "initials": "Y"}, {"family": "Grover", "given": "Steven P", "initials": "SP"}, {"family": "Rosell", "given": "Axel", "initials": "A"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "von Meijenfeldt", "given": "Fien", "initials": "F"}, {"family": "Aguilera", "given": "Katherina", "initials": "K"}, {"family": "Lisman", "given": "Ton", "initials": "T"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "letter", "published": "2021-06-00", "journal": {"title": "Arterioscler Thromb Vasc Biol", "issn": "1524-4636", "volume": "41", "issue": "6", "pages": "e381-e382", "issn-l": null}, "abstract": null, "doi": "10.1161/ATVBAHA.121.316203", "pmid": "34038165", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-29T15:33:21.987Z", "modified": "2021-05-29T15:33:21.996Z"}, {"entity": "publication", "iuid": "bd5c6eab824541e4a1713a503582837f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bd5c6eab824541e4a1713a503582837f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bd5c6eab824541e4a1713a503582837f"}}, "title": "Rehabilitation needs and mortality associated with the Covid-19 pandemic: a population-based study of all hospitalised and home-healthcare individuals in a Swedish healthcare region.", "authors": [{"family": "Divanoglou", "given": "Anestis", "initials": "A"}, {"family": "Samuelsson", "given": "Assoc Prof Kersti", "initials": "APK"}, {"family": "Sj\u00f6dahl", "given": "Prof Emer Rune", "initials": "PER"}, {"family": "Andersson", "given": "Christer", "initials": "C"}, {"family": "Levi", "given": "Prof Richard", "initials": "PR"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "issn-l": null, "volume": "36", "issue": null, "pages": "100920"}, "abstract": "This first report of the Link\u00f6ping Covid-19 Study (LinCoS) aimed at determination of Covid-19-associated mortality, impairments, activity and participation limitations denoting rehabilitation needs four months after discharge from hospital.\r\n\r\nAn ambidirectional population-based cohort study including all confirmed Covid-19 cases admitted to hospital during 1/03-31/05 and those living in home healthcare settings identified through a regional registry and evaluated through medical records, including WHO Clinical Progression Scale (CPS). All patients discharged from hospital were followed-up by structured telephone interview at 4 months post-discharge. Respondents indicated any new or aggravated persisting problems in any of 25 body functions and 12 activity/participation items and rated them for impact on daily life.\r\n\r\nOut of 734 hospitalised patients, 149 were excluded, 125 died, and 460 were alive at 4-month follow-up of whom 433 (94.1%) were interviewed. In total, 40% reported impairments and activity/participation limitations affecting daily life and warranted further multi-professional rehabilitation assessment, predominantly those with severe disease and a considerable proportion of those with moderate disease. Cognitive and affective impairments were equally common in all groups and were reported by 20-40% of cases. Limb weakness was reported by 31%, with CPS 7-9 being four times more likely to report this problem as compared to CPS 4-5. 26% of those working or studying reported difficulties returning to these activities, this being 3.5 times more likely in CPS 7-9 as compared to CPS 4-5. 25% reported problems walking >1 km, with CPS 7-9 over three times more likely to report this as compared to the other two sub-groups. 90-day mortality rate of Covid-19 associated deaths was 15.1%.\r\n\r\nMost rehabilitation needs after Covid-19 involved higher cerebral dysfunction both in patients with moderate and severe disease. This should be considered when designing services aiming at minimizing long-term disability.\r\n\r\nALF grant and Region \u00d6sterg\u00f6tland.", "doi": "10.1016/j.eclinm.2021.100920", "pmid": "34095795", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(21)00200-5"}, {"db": "pmc", "key": "PMC8164661"}], "notes": [], "created": "2021-06-08T09:00:47.968Z", "modified": "2021-07-14T09:11:25.676Z"}, {"entity": "publication", "iuid": "85fe5abcf3b7455493fc233a38c9d883", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/85fe5abcf3b7455493fc233a38c9d883.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/85fe5abcf3b7455493fc233a38c9d883"}}, "title": "Proteome profiling of recombinant DNase therapy in reducing NETs and aiding recovery in COVID-19 patients", "authors": [{"family": "Fisher", "given": "Jane", "initials": "J"}, {"family": "Mohanty", "given": "Tirthankar", "initials": "T"}, {"family": "Karlsson", "given": "Christofer", "initials": "C"}, {"family": "Khademi", "given": "S M Hossein", "initials": "SMH"}, {"family": "Malmstr\u00f6m", "given": "Erik", "initials": "E"}, {"family": "Frigyesi", "given": "Attila", "initials": "A"}, {"family": "Nordenfelt", "given": "Pontus", "initials": "P"}, {"family": "Malmstrom", "given": "Johan", "initials": "J"}, {"family": "Linder", "given": "Adam", "initials": "A"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "Molecular & Cellular Proteomics", "issn": "1535-9476", "issn-l": null, "volume": null, "issue": null, "pages": "100113"}, "abstract": "Severe COVID-19 can result in pneumonia and acute respiratory failure. Accumulation of mucus in the airways is a hall mark of the disease and can result in hypoxemia. Here, we show that quantitative proteome analysis of the sputum from severe COVID-19 patients reveal high levels of neutrophil extracellular trap(s) (NETs) components, which was confirmed by microscopy. Extracellular DNA from excessive NET formation can increase sputum viscosity and can lead to acute respiratory distress syndrome (ARDS). Recombinant human DNase (rhDNase/Pulmozyme) has been shown to be beneficial in reducing sputum viscosity and improve lung function. We treated 5 COVID-19 patients presenting acute symptoms with clinically approved aerosolized Pulmozyme. No adverse reactions to the drug were seen, and improved oxygen saturation and recovery in all severely ill COVID-19 patients was observed after therapy. Immunofluorescence and proteome analysis of sputum and blood plasma samples after treatment revealed a marked reduction of NETs and a set of statistically significant proteome changes that indicate reduction of haemorrhage, plasma leakage and inflammation in the airways, and reduced systemic inflammatory state in the blood plasma of patients. Taken together, the results indicate that NETs contribute to acute respiratory failure in COVID-19 and that degrading NETs may reduce dependency on external high flow oxygen therapy in patients. Targeting NETs using rhDNase may have significant therapeutic implications in COVID-19 disease and warrants further studies.", "doi": "10.1016/j.mcpro.2021.100113", "pmid": "34139362", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S1535-9476(21)00085-2"}, {"db": "pmc", "key": "PMC8205261"}, {"db": "PRIDE", "key": "https://www.ebi.ac.uk/pride/archive/projects/PXD021197", "description": "COVID-19 proteome profiling reveals resolution of inflammatory pathways and respiratory distress after DNase treatment"}], "notes": [], "created": "2021-06-28T18:31:04.166Z", "modified": "2021-11-18T13:36:33.841Z"}, {"entity": "publication", "iuid": "a82bd6da695c4af2b35286616494696c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a82bd6da695c4af2b35286616494696c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a82bd6da695c4af2b35286616494696c"}}, "title": "Prevalence of SARS-CoV-2 in Communities Through Wastewater Surveillance\u2014a Potential Approach for Estimation of Disease Burden", "authors": [{"family": "Bhattacharya", "given": "Prosun", "initials": "P", "orcid": "0000-0003-4350-9950", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06f71013630d4ed08a8672a7e86ce6bf.json"}}, {"family": "Kumar", "given": "Manish", "initials": "M"}, {"family": "Islam", "given": "Md Tahmidul", "initials": "MT"}, {"family": "Haque", "given": "Rehnuma", "initials": "R"}, {"family": "Chakraborty", "given": "Sudip", "initials": "S"}, {"family": "Ahmad", "given": "Arslan", "initials": "A"}, {"family": "Niazi", "given": "Nabeel Khan", "initials": "NK"}, {"family": "Cetecioglu", "given": "Zeynep", "initials": "Z"}, {"family": "Nilsson", "given": "David", "initials": "D"}, {"family": "Ijumulana", "given": "Julian", "initials": "J"}, {"family": "van der Voorn", "given": "Tom", "initials": "T"}, {"family": "Jakariya", "given": "Md", "initials": "M"}, {"family": "Hossain", "given": "Maqsud", "initials": "M"}, {"family": "Ahmed", "given": "Firoz", "initials": "F"}, {"family": "Rahman", "given": "Mahbubur", "initials": "M"}, {"family": "Akter", "given": "Nargis", "initials": "N"}, {"family": "Johnston", "given": "Dara", "initials": "D"}, {"family": "Ahmed", "given": "Kazi Matin", "initials": "KM"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "Curr Pollut Rep", "issn": "2198-6592", "issn-l": null, "volume": "7", "issue": "2", "pages": "160-166"}, "abstract": "The episodic outbreak of COVID-19 due to SARS-CoV-2 is severely affecting the economy, and the global count of infected patients is increasing. The actual number of patients had been underestimated due to limited facilities for testing as well as asymptomatic nature of the expression of COVID-19 on individual basis. Tragically, for emerging economies with high population density, the situation has been more complex due to insufficient testing facilities for diagnosis of the disease. However, the recent reports about persistent shedding of viral RNA of SARS-CoV-2 in the human feces have created a possibility to track the prevalence and trends of the disease in communities, known as wastewater-based epidemiology (WBE). In this article, we highlight the current limitations and future prospects for WBE to manage pandemics.", "doi": "10.1007/s40726-021-00178-4", "pmid": "33842197", "labels": {"Research Area: Environmental virus profiling": null, "Funder: KAW/SciLifeLab": null, "Type: Review": null}, "xrefs": [{"db": "pii", "key": "178"}, {"db": "pmc", "key": "PMC8021931"}], "notes": [], "created": "2021-04-13T09:40:35.469Z", "modified": "2021-06-18T08:45:52.985Z"}, {"entity": "publication", "iuid": "f09cc223d49a4f3781c4d702e7d588fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f09cc223d49a4f3781c4d702e7d588fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f09cc223d49a4f3781c4d702e7d588fc"}}, "title": "Preterm Birth and Stillbirth During the COVID-19 Pandemic in Sweden: A Nationwide Cohort Study.", "authors": [{"family": "Pasternak", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-2097-8466", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c3b2692f334845c184219da7da7483d2.json"}}, {"family": "Neovius", "given": "Martin", "initials": "M", "orcid": "0000-0003-2300-3055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78e60d3149ce4ac994ddeaa441514ef6.json"}}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Ahlberg", "given": "Mia", "initials": "M", "orcid": "0000-0001-8612-6277", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4bb9a2d40e1478097dc3a95c6a8c9f3.json"}}, {"family": "Norman", "given": "Mikael", "initials": "M", "orcid": "0000-0003-4191-3781", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5346954396864ffbb8a1380e15c7dba7.json"}}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF", "orcid": "0000-0003-1024-5602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1d5e45881a7469ca20a0eb360d891cc.json"}}, {"family": "Stephansson", "given": "Olof", "initials": "O", "orcid": "0000-0003-1528-4563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39af50356a574c80ba6bd2227ecb5cf5.json"}}], "type": "letter", "published": "2021-06-00", "journal": {"title": "Ann Intern Med", "issn": "1539-3704", "volume": "174", "issue": "6", "pages": "873-875", "issn-l": "0003-4819"}, "abstract": null, "doi": "10.7326/M20-6367", "pmid": "33428442", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7808327"}], "notes": [], "created": "2023-01-05T09:33:03.361Z", "modified": "2023-01-05T09:33:20.337Z"}, {"entity": "publication", "iuid": "ffa3b7d3a56044fc9a89e408e7db2859", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ffa3b7d3a56044fc9a89e408e7db2859.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ffa3b7d3a56044fc9a89e408e7db2859"}}, "title": "Parkinson's Disease and Post-COVID-19 Syndrome: The Parkinson's Long-COVID Spectrum.", "authors": [{"family": "Leta", "given": "Valentina", "initials": "V", "orcid": "0000-0002-5794-7540", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15265d9377c342df8506ee8a06708525.json"}}, {"family": "Rodr\u00edguez-Violante", "given": "Mayela", "initials": "M", "orcid": "0000-0002-6041-9941", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a434345ba2d4075913a2af5b00e318a.json"}}, {"family": "Abundes", "given": "Arturo", "initials": "A"}, {"family": "Rukavina", "given": "Katarina", "initials": "K"}, {"family": "Teo", "given": "James T", "initials": "JT"}, {"family": "Falup-Pecurariu", "given": "Cristian", "initials": "C"}, {"family": "Irincu", "given": "Laura", "initials": "L"}, {"family": "Rota", "given": "Silvia", "initials": "S"}, {"family": "Bhidayasiri", "given": "Roongroj", "initials": "R", "orcid": "0000-0002-6901-2064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78c370775b434ae281b3a0e57367686c.json"}}, {"family": "Storch", "given": "Alexander", "initials": "A"}, {"family": "Odin", "given": "Per", "initials": "P"}, {"family": "Antonini", "given": "Angelo", "initials": "A", "orcid": "0000-0003-1040-2807", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02f966fef60c46a9aa7be04923ea0a2a.json"}}, {"family": "Ray Chaudhuri", "given": "Kallol", "initials": "K", "orcid": "0000-0003-2815-0505", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92bb30651ec5484f8a1364222efcce5a.json"}}], "type": "letter", "published": "2021-06-00", "journal": {"title": "Mov Disord", "issn": "1531-8257", "issn-l": null, "volume": "36", "issue": "6", "pages": "1287-1289"}, "abstract": null, "doi": "10.1002/mds.28622", "pmid": "33890344", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8250675"}], "notes": [], "created": "2021-04-29T16:10:06.261Z", "modified": "2023-01-13T13:24:33.196Z"}, {"entity": "publication", "iuid": "088b14ba53f7445899eef52f4f1addf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/088b14ba53f7445899eef52f4f1addf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/088b14ba53f7445899eef52f4f1addf3"}}, "title": "Orthodontic retention: what's on the horizon?", "authors": [{"family": "Littlewood", "given": "Simon J", "initials": "SJ"}, {"family": "Dalci", "given": "Oyku", "initials": "O"}, {"family": "Dolce", "given": "Calogero", "initials": "C"}, {"family": "Holliday", "given": "L Shannon", "initials": "LS"}, {"family": "Naraghi", "given": "Sasan", "initials": "S"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Br Dent J", "issn": "1476-5373", "volume": "230", "issue": "11", "pages": "760-764", "issn-l": null}, "abstract": "Orthodontic retention remains one of the great challenges in orthodontics. In this article, we discuss what is on the horizon to help address this challenge, including biological approaches to reduce relapse, treating patients without using retainers, technological developments, personalised medicine and the impact of COVID-19 on approaches to orthodontic retention.", "doi": "10.1038/s41415-021-2937-8", "pmid": "34117435", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41415-021-2937-8"}], "notes": [], "created": "2021-06-14T06:33:28.931Z", "modified": "2021-06-14T06:33:28.938Z"}, {"entity": "publication", "iuid": "638334507f99412a8f18438594fcaacd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/638334507f99412a8f18438594fcaacd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/638334507f99412a8f18438594fcaacd"}}, "title": "Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2", "authors": [{"family": "Hassan", "given": "Sk Sarif", "initials": "SS"}, {"family": "Attrish", "given": "Diksha", "initials": "D"}, {"family": "Ghosh", "given": "Shinjini", "initials": "S"}, {"family": "Choudhury", "given": "Pabitra Pal", "initials": "PP"}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN"}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA"}, {"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Uhal", "given": "Bruce D", "initials": "BD"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Seyran", "given": "Murat", "initials": "M"}, {"family": "Pizzol", "given": "Damiano", "initials": "D"}, {"family": "Adadi", "given": "Parise", "initials": "P"}, {"family": "Soares", "given": "Antonio", "initials": "A"}, {"family": "Abd El-Aziz", "given": "Tarek Mohamed", "initials": "TM"}, {"family": "Kandimalla", "given": "Ramesh", "initials": "R"}, {"family": "Tambuwala", "given": "Murtaza M", "initials": "MM"}, {"family": "Azad", "given": "Gajendra Kumar", "initials": "GK"}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Baetas-da-Cruz", "given": "Wagner", "initials": "W"}, {"family": "Lal", "given": "Amos", "initials": "A"}, {"family": "Pal\u00f9", "given": "Giorgio", "initials": "G"}, {"family": "Takayama", "given": "Kazuo", "initials": "K"}, {"family": "Serrano-Aroca", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "Barh", "given": "Debmalya", "initials": "D"}, {"family": "Brufsky", "given": "Adam M", "initials": "AM"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "International Journal of Biological Macromolecules", "issn": "0141-8130", "volume": "181", "issue": null, "pages": "801-809", "issn-l": null}, "abstract": null, "doi": "10.1016/j.ijbiomac.2021.03.199", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-19T10:37:28.411Z", "modified": "2021-04-19T10:37:28.436Z"}, {"entity": "publication", "iuid": "c80dd926ac8d4140824baeb0ba34e4e5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c80dd926ac8d4140824baeb0ba34e4e5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c80dd926ac8d4140824baeb0ba34e4e5"}}, "title": "Modest effects of dietary supplements during the COVID-19 pandemic: insights from 445 850 users of the COVID-19 Symptom Study app", "authors": [{"family": "Louca", "given": "Panayiotis", "initials": "P", "orcid": "0000-0001-5956-1433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44d3563d8537415488d45a381ccd0604.json"}}, {"family": "Murray", "given": "Benjamin", "initials": "B", "orcid": "0000-0002-8198-8131", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/633d9bf9646d4c07a6611f21e67dc798.json"}}, {"family": "Klaser", "given": "Kerstin", "initials": "K", "orcid": "0000-0002-5230-6939", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6eaf3d777b444dec814026eceb65de8c.json"}}, {"family": "Graham", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-4170-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f5f4e19812a46ed9e873732ec25e28d.json"}}, {"family": "Mazidi", "given": "Mohsen", "initials": "M", "orcid": "0000-0003-3059-229X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d50a209c0b64f3b93703515c57f1334.json"}}, {"family": "Leeming", "given": "Emily R", "initials": "ER", "orcid": "0000-0002-0531-4901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59a9e4a4912f451c861668efdd226c44.json"}}, {"family": "Thompson", "given": "Ellen", "initials": "E", "orcid": "0000-0003-2118-821X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6754739394b24a5c8f5db22905b22c3c.json"}}, {"family": "Bowyer", "given": "Ruth", "initials": "R", "orcid": "0000-0002-6941-8160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eebaf361c184499ca6729aa60cc0af3d.json"}}, {"family": "Drew", "given": "David A", "initials": "DA", "orcid": "0000-0002-8813-0816", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd3a2cffdc104f18b8684cf4f27d68b2.json"}}, {"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Merino", "given": "Jordi", "initials": "J", "orcid": "0000-0001-8312-1438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12ab049914a542b39affcfb4196861d2.json"}}, {"family": "Gomez", "given": "Maria", "initials": "M", "orcid": "0000-0001-6210-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e09e37219c4f42c8a7b3a982da523859.json"}}, {"family": "Mompeo", "given": "Olatz", "initials": "O", "orcid": "0000-0002-1754-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2051c14cd79e43b3b1f168c7c896aa8a.json"}}, {"family": "Costeira", "given": "Ricardo", "initials": "R", "orcid": "0000-0002-8316-5219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f9a3632463540a4930b5f7ac70d0faa.json"}}, {"family": "Sudre", "given": "Carole H", "initials": "CH", "orcid": "0000-0001-5753-428X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c26472813fed4007a8757af771de1802.json"}}, {"family": "Gibson", "given": "Rachel", "initials": "R", "orcid": "0000-0002-5823-6468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/def9e18b28a34704b6d658bc0d82fa14.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74cf1f7094744ee289fa5df041e7cb5b.json"}}, {"family": "Ourselin", "given": "Sebastien", "initials": "S", "orcid": "0000-0002-5694-5340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74c7b9b1633144879042d198c7205656.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-7284-6767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeefbf47fd384d5390109fe1a903bd18.json"}}, {"family": "Berry", "given": "Sarah E", "initials": "SE", "orcid": "0000-0002-5819-5109", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90a2ad26c7694c379586df859629c77d.json"}}, {"family": "Valdes", "given": "Ana M", "initials": "AM", "orcid": "0000-0003-1141-4471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25a57a383f7f42ad82558fa66564fdf9.json"}}, {"family": "Calder", "given": "Philip C", "initials": "PC", "orcid": "0000-0002-6038-710X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0057aacc763d4e448ba964c8c238a32b.json"}}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874802ae65824a90ba50eabdeabb8356.json"}}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "BMJ Nutr Prev Health", "issn": "2516-5542", "volume": "4", "issue": "1", "pages": "149-157", "issn-l": null}, "abstract": "Dietary supplements may ameliorate SARS-CoV-2 infection, although scientific evidence to support such a role is lacking. We investigated whether users of the COVID-19 Symptom Study app who regularly took dietary supplements were less likely to test positive for SARS-CoV-2 infection.\n\nApp-based community survey.\n\n445 850 subscribers of an app that was launched to enable self-reported information related to SARS-CoV-2 infection for use in the general population in the UK (n=372 720), the USA (n=45 757) and Sweden (n=27 373).\n\nSelf-reported regular dietary supplement usage (constant use during previous 3 months) in the first waves of the pandemic up to 31 July 2020.\n\nSARS-CoV-2 infection confirmed by viral RNA reverse transcriptase PCR test or serology test before 31 July 2020.\n\nIn 372 720 UK participants (175 652 supplement users and 197 068 non-users), those taking probiotics, omega-3 fatty acids, multivitamins or vitamin D had a lower risk of SARS-CoV-2 infection by 14% (95% CI (8% to 19%)), 12% (95% CI (8% to 16%)), 13% (95% CI (10% to 16%)) and 9% (95% CI (6% to 12%)), respectively, after adjusting for potential confounders. No effect was observed for those taking vitamin C, zinc or garlic supplements. On stratification by sex, age and body mass index (BMI), the protective associations in individuals taking probiotics, omega-3 fatty acids, multivitamins and vitamin D were observed in females across all ages and BMI groups, but were not seen in men. The same overall pattern of association was observed in both the US and Swedish cohorts.\n\nIn women, we observed a modest but significant association between use of probiotics, omega-3 fatty acid, multivitamin or vitamin D supplements and lower risk of testing positive for SARS-CoV-2. We found no clear benefits for men nor any effect of vitamin C, garlic or zinc. Randomised controlled trials are required to confirm these observational findings before any therapeutic recommendations can be made.", "doi": "10.1136/bmjnph-2021-000250", "pmid": "34308122", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjnph-2021-000250"}, {"db": "pmc", "key": "PMC8061565"}, {"db": "URL", "key": "https://covid.joinzoe.com", "description": "ZOE COVID Study website (providing information on raw data and data visualisations)"}, {"db": "URL", "key": "https://nutrition.bmj.com/content/4/1/149#supplementary-materials", "description": "Supplementary Information (includes information on relevant survey questions, summary statistics and flowcharts about the study)"}], "notes": [], "created": "2021-08-05T06:54:01.869Z", "modified": "2021-08-13T05:42:50.446Z"}, {"entity": "publication", "iuid": "aa000107f0344b9089a9673d588ec8f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aa000107f0344b9089a9673d588ec8f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aa000107f0344b9089a9673d588ec8f8"}}, "title": "Longitudinal variability in mortality predicts COVID-19 deaths.", "authors": [{"family": "Lundberg", "given": "Jon O", "initials": "JO", "orcid": "0000-0002-0174-5210", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78a32d00021a47db8c21c5a4f2419638.json"}}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ee1510080704cf6a2a6972deb94123f.json"}}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Eur J Epidemiol", "issn": "1573-7284", "issn-l": "0393-2990", "volume": "36", "issue": "6", "pages": "599-603"}, "abstract": "Within Europe, death rates due to COVID-19 vary greatly, with some countries being severely hit while others to date are almost unaffected. This has created a heated debate in particular regarding how effective the different measures applied by the governments are in limiting the spread of the disease and ultimately deaths. It would be of considerable interest to pinpoint the factors that determine a country's susceptibility to a pandemic such as COVID-19. Here we present data demonstrating that mortality due to COVID-19 in a given country could have been predicted to some extent even before the pandemic hit Europe, simply by looking at longitudinal variability of death rates in the years preceding the current outbreak. The variability in death rates during the winter influenza seasons of 2015-2019 correlates to excess mortality in 2020 during the COVID-19 outbreak (Spearman's \u03c1 = 0.68, 95 % CI = 0.40-0.84, p < 0.001). In contrast, there was no correlation with age, population density, latitude, GNP, governmental health spending, number of intensive care beds, degree of urbanization, or rates of influenza vaccination. These data suggest an intrinsic susceptibility in certain countries to excess mortality associated with viral respiratory diseases including COVID-19.", "doi": "10.1007/s10654-021-00777-x", "pmid": "34218343", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10654-021-00777-x"}, {"db": "pmc", "key": "PMC8254667"}], "notes": [], "created": "2021-07-05T15:07:36.224Z", "modified": "2021-08-16T14:24:38.154Z"}, {"entity": "publication", "iuid": "90a791f266b04f929d7c174b43847ea9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90a791f266b04f929d7c174b43847ea9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90a791f266b04f929d7c174b43847ea9"}}, "title": "Immunogenicity of the BNT162b2 vaccine in frail or disabled nursing home residents: COVID-A study.", "authors": [{"family": "Salmer\u00f3n R\u00edos", "given": "Sergio", "initials": "S"}, {"family": "Mas Romero", "given": "Marta", "initials": "M"}, {"family": "Cort\u00e9s Zamora", "given": "Elisa Bel\u00e9n", "initials": "EB"}, {"family": "Tabernero Sahuquillo", "given": "Mar\u00eda Teresa", "initials": "MT"}, {"family": "Romero Rizos", "given": "Luis", "initials": "L"}, {"family": "S\u00e1nchez-Jurado", "given": "Pedro Manuel", "initials": "PM"}, {"family": "S\u00e1nchez-Nievas", "given": "Gin\u00e9s", "initials": "G"}, {"family": "Se\u00f1alada", "given": "Jos\u00e9 Joaqu\u00edn Blas", "initials": "JJB"}, {"family": "Garc\u00eda Nogueras", "given": "Inmaculada", "initials": "I"}, {"family": "Estrella Cazalla", "given": "Juan de Dios", "initials": "JdD"}, {"family": "Andr\u00e9s-Pretel", "given": "Fernando", "initials": "F"}, {"family": "Murillo Romero", "given": "Antonio", "initials": "A"}, {"family": "Lauschke", "given": "Volker Martin", "initials": "VM"}, {"family": "Stebbing", "given": "Justin", "initials": "J"}, {"family": "Abizanda", "given": "Pedro", "initials": "P"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "J Am Geriatr Soc", "issn": "0002-8614", "volume": "69", "issue": "6", "issn-l": null, "pages": "1441-1447"}, "abstract": "The safety and immunogenicity of the BNT162b2 coronavirus disease 2019 (COVID-19) vaccine in older adults with different frailty and disability profiles have not been well determined. Our objective was to analyze immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in older adults across frailty and disability profiles.\r\n\r\nMulticenter longitudinal cohort study.\r\n\r\nA total of 134 residents aged \u226565 years with different frailty and disability profiles in five long-term care facilities (LTCFs) in Albacete, Spain.\r\n\r\nResidents were administered two vaccine doses as per the label, and antibody levels were determined 21.9 days (SD 9.3) after both the first and second dose. Functional variables were assessed using activities of daily living (Barthel Index), and frailty status was determined with the FRAIL instrument. Cognitive status and comorbidity were also evaluated.\r\n\r\nMean age was 82.9 years (range 65-99), and 71.6% were female. The mean antibody titers in residents with and without previous COVID-19 infection were 49,878 AU/ml and 15,274 AU/ml, respectively (mean difference 34,604; 95% confidence interval [CI]: 27,699-41,509). No severe adverse reactions were observed, after either vaccine dose. Those with prevaccination COVID-19 had an increased antibody level after the vaccine (B = 31,337; 95% CI: 22,725-39,950; p < 0.001). Frailty, disability, older age, sex, cognitive impairment, or comorbidities were not associated with different antibody titers.\r\n\r\nThe BNT162b2 mRNA COVID-19 vaccine in older adults is safe and produces immunogenicity, independently of the frailty and disability profiles. Older adults in LTCFs should receive a COVID-19 vaccine.", "doi": "10.1111/jgs.17153", "pmid": "33768521", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8250586"}], "notes": [], "created": "2021-03-29T09:26:15.643Z", "modified": "2021-08-23T14:39:35.931Z"}, {"entity": "publication", "iuid": "885b12d94aef4f74a878db2b333fbae4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/885b12d94aef4f74a878db2b333fbae4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/885b12d94aef4f74a878db2b333fbae4"}}, "title": "Guest attendance data from 34 Swedish pre-schools and primary schools.", "authors": [{"family": "Eriksson", "given": "Mattias", "initials": "M"}, {"family": "Malefors", "given": "Christopher", "initials": "C"}, {"family": "Secondi", "given": "Luca", "initials": "L"}, {"family": "Marchetti", "given": "Stefano", "initials": "S"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Data Brief", "issn": "2352-3409", "issn-l": null, "volume": "36", "issue": null, "pages": "107138"}, "abstract": "This data article describes 34 datasets, compiled into one table, describing guest attendance at lunch meal servings in Swedish public schools and preschools. Fifteen of the schools and all 16 of the preschools covered belong to one municipality, while the remaining three schools belong to two other municipalities, all located in central Sweden. Data on number of plates was used as a proxy of the number of guests eating lunch. Number of used plates was recorded from late August 2010 to early June 2020, i.e. covering the period both before and during the initial phase of the Covid-19 pandemic, so that making possible to evaluate changes in guest attendance during the pandemic. Since these were real data, all data elements pertaining to exact canteens or staff identity have been removed. There is a scarcity of real business data for scientific and educational purposes, so these datasets can play an important role in research and education within catering management, consumption pattern analysis, machine learning, data mining and other fields.", "doi": "10.1016/j.dib.2021.107138", "pmid": "34095385", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S2352-3409(21)00422-4"}, {"db": "pmc", "key": "PMC8165408"}], "notes": [], "created": "2021-06-08T08:56:05.493Z", "modified": "2022-11-22T05:46:23.879Z"}, {"entity": "publication", "iuid": "2ebb0a439bad48b093252fcb2a666c35", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ebb0a439bad48b093252fcb2a666c35.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ebb0a439bad48b093252fcb2a666c35"}}, "title": "Extracellular Vesicle Capture by AnTibody of CHoice and Enzymatic Release (EV-CATCHER): A customizable purification assay designed for small-RNA biomarker identification and evaluation of circulating small-EVs.", "authors": [{"family": "Mitchell", "given": "Megan I", "initials": "MI", "orcid": "0000-0002-1202-155X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a39353b6a1040bda4fc6ec41ce992cf.json"}}, {"family": "Ben-Dov", "given": "Iddo Z", "initials": "IZ"}, {"family": "Liu", "given": "Christina", "initials": "C"}, {"family": "Ye", "given": "Kenny", "initials": "K"}, {"family": "Chow", "given": "Kar", "initials": "K"}, {"family": "Kramer", "given": "Yael", "initials": "Y"}, {"family": "Gangadharan", "given": "Anju", "initials": "A"}, {"family": "Park", "given": "Steven", "initials": "S"}, {"family": "Fitzgerald", "given": "Sean", "initials": "S"}, {"family": "Ramnauth", "given": "Andrew", "initials": "A"}, {"family": "Perlin", "given": "David S", "initials": "DS"}, {"family": "Donato", "given": "Michele", "initials": "M"}, {"family": "Bhoy", "given": "Emily", "initials": "E"}, {"family": "Manouchehri Doulabi", "given": "Ehsan", "initials": "E"}, {"family": "Poulos", "given": "Michael", "initials": "M"}, {"family": "Kamali-Moghaddam", "given": "Masood", "initials": "M"}, {"family": "Loudig", "given": "Olivier", "initials": "O"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "J Extracell Vesicles", "issn": "2001-3078", "issn-l": null, "volume": "10", "issue": "8", "pages": "e12110"}, "abstract": "Circulating nucleic acids, encapsulated within small extracellular vesicles (EVs), provide a remote cellular snapshot of biomarkers derived from diseased tissues, however selective isolation is critical. Current laboratory-based purification techniques rely on the physical properties of small-EVs rather than their inherited cellular fingerprints. We established a highly-selective purification assay, termed EV-CATCHER, initially designed for high-throughput analysis of low-abundance small-RNA cargos by next-generation sequencing. We demonstrated its selectivity by specifically isolating and sequencing small-RNAs from mouse small-EVs spiked into human plasma. Western blotting, nanoparticle tracking, and transmission electron microscopy were used to validate and quantify the capture and release of intact small-EVs. As proof-of-principle for sensitive detection of circulating miRNAs, we compared small-RNA sequencing data from a subset of small-EVs serum-purified with EV-CATCHER to data from whole serum, using samples from a small cohort of recently hospitalized Covid-19 patients. We identified and validated, only in small-EVs, hsa-miR-146a and hsa-miR-126-3p to be significantly downregulated with disease severity. Separately, using convalescent sera from recovered Covid-19 patients with high anti-spike IgG titers, we confirmed the neutralizing properties, against SARS-CoV-2 in vitro, of a subset of small-EVs serum-purified by EV-CATCHER, as initially observed with ultracentrifuged small-EVs. Altogether our data highlight the sensitivity and versatility of EV-CATCHER.", "doi": "10.1002/jev2.12110", "pmid": "34122779", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8173589"}, {"db": "pii", "key": "JEV212110"}], "notes": [], "created": "2021-06-17T07:28:31.678Z", "modified": "2023-06-19T15:06:28.471Z"}, {"entity": "publication", "iuid": "3fea64a67cbe40219cc97c9ee830c67a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3fea64a67cbe40219cc97c9ee830c67a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3fea64a67cbe40219cc97c9ee830c67a"}}, "title": "Excess Mortality After COVID-19 in Swedish Long-Term Care Facilities", "authors": [{"family": "Ballin", "given": "Marcel", "initials": "M"}, {"family": "Bergman", "given": "Jonathan", "initials": "J"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Nordstr\u00f6m", "given": "Peter", "initials": "P"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "Journal of the American Medical Directors Association", "issn": "1525-8610", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/j.jamda.2021.06.010", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:08:23.850Z", "modified": "2021-07-14T09:13:47.733Z"}, {"entity": "publication", "iuid": "6e3d5779e96c4475b28d9954590d053a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e3d5779e96c4475b28d9954590d053a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e3d5779e96c4475b28d9954590d053a"}}, "title": "Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and territories in the Invasive Respiratory Infection Surveillance Initiative: a prospective analysis of surveillance data", "authors": [{"family": "Brueggemann", "given": "Angela B", "initials": "AB"}, {"family": "Jansen van Rensburg", "given": "Melissa J", "initials": "MJ"}, {"family": "Shaw", "given": "David", "initials": "D"}, {"family": "McCarthy", "given": "Noel D", "initials": "ND"}, {"family": "Jolley", "given": "Keith A", "initials": "KA"}, {"family": "Maiden", "given": "Martin C J", "initials": "MCJ"}, {"family": "van der Linden", "given": "Mark P G", "initials": "MPG"}, {"family": "Amin-Chowdhury", "given": "Zahin", "initials": "Z"}, {"family": "Bennett", "given": "D\u00e9sir\u00e9e E", "initials": "DE"}, {"family": "Borrow", "given": "Ray", "initials": "R"}, {"family": "Brandileone", "given": "Maria Cristina C", "initials": "MCC"}, {"family": "Broughton", "given": "Karen", "initials": "K"}, {"family": "Campbell", "given": "Ruth", "initials": "R"}, {"family": "Cao", "given": "Bin", "initials": "B"}, {"family": "Casanova", "given": "Carlo", "initials": "C"}, {"family": "Choi", "given": "Eun Hwa", "initials": "EH"}, {"family": "Chu", "given": "Yiu Wai", "initials": "YW"}, {"family": "Clark", "given": "Stephen A", "initials": "SA"}, {"family": "Claus", "given": "Heike", "initials": "H"}, {"family": "Coelho", "given": "Juliana", "initials": "J"}, {"family": "Corcoran", "given": "Mary", "initials": "M"}, {"family": "Cottrell", "given": "Simon", "initials": "S"}, {"family": "Cunney", "given": "Robert J", "initials": "RJ"}, {"family": "Dalby", "given": "Tine", "initials": "T"}, {"family": "Davies", "given": "Heather", "initials": "H"}, {"family": "de Gouveia", "given": "Linda", "initials": "L"}, {"family": "Deghmane", "given": "Ala Eddine", "initials": "AE"}, {"family": "Demczuk", "given": "Walter", "initials": "W"}, {"family": "Desmet", "given": "Stefanie", "initials": "S"}, {"family": "Drew", "given": "Richard J", "initials": "RJ"}, {"family": "du Plessis", "given": "Mignon", "initials": "M"}, {"family": "Erlendsdottir", "given": "Helga", "initials": "H"}, {"family": "Fry", "given": "Norman K", "initials": "NK"}, {"family": "Fuursted", "given": "Kurt", "initials": "K"}, {"family": "Gray", "given": "Steve J", "initials": "SJ"}, {"family": "Henriques-Normark", "given": "Birgitta", "initials": "B"}, {"family": "Hale", "given": "Thomas", "initials": "T"}, {"family": "Hilty", "given": "Markus", "initials": "M"}, {"family": "Hoffmann", "given": "Steen", "initials": "S"}, {"family": "Humphreys", "given": "Hilary", "initials": "H"}, {"family": "Ip", "given": "Margaret", "initials": "M"}, {"family": "Jacobsson", "given": "Susanne", "initials": "S"}, {"family": "Johnston", "given": "Jillian", "initials": "J"}, {"family": "Kozakova", "given": "Jana", "initials": "J"}, {"family": "Kristinsson", "given": "Karl G", "initials": "KG"}, {"family": "Krizova", "given": "Pavla", "initials": "P"}, {"family": "Kuch", "given": "Alicja", "initials": "A"}, {"family": "Ladhani", "given": "Shamez N", "initials": "SN"}, {"family": "L\u00e2m", "given": "Thi\u00ean Tr\u00ed", "initials": "TT"}, {"family": "Lebedova", "given": "Vera", "initials": "V"}, {"family": "Lindholm", "given": "Laura", "initials": "L"}, {"family": "Litt", "given": "David J", "initials": "DJ"}, {"family": "Martin", "given": "Irene", "initials": "I"}, {"family": "Martiny", "given": "Delphine", "initials": "D"}, {"family": "Mattheus", "given": "Wesley", "initials": "W"}, {"family": "McElligott", "given": "Martha", "initials": "M"}, {"family": "Meehan", "given": "Mary", "initials": "M"}, {"family": "Meiring", "given": "Susan", "initials": "S"}, {"family": "M\u00f6lling", "given": "Paula", "initials": "P"}, {"family": "Morfeldt", "given": "Eva", "initials": "E"}, {"family": "Morgan", "given": "Julie", "initials": "J"}, {"family": "Mulhall", "given": "Robert M", "initials": "RM"}, {"family": "Mu\u00f1oz-Almagro", "given": "Carmen", "initials": "C"}, {"family": "Murdoch", "given": "David R", "initials": "DR"}, {"family": "Murphy", "given": "Joy", "initials": "J"}, {"family": "Musilek", "given": "Martin", "initials": "M"}, {"family": "Mzabi", "given": "Alexandre", "initials": "A"}, {"family": "Perez-Arg\u00fcello", "given": "Amaresh", "initials": "A"}, {"family": "Perrin", "given": "Monique", "initials": "M"}, {"family": "Perry", "given": "Malorie", "initials": "M"}, {"family": "Redin", "given": "Alba", "initials": "A"}, {"family": "Roberts", "given": "Richard", "initials": "R"}, {"family": "Roberts", "given": "Maria", "initials": "M"}, {"family": "Rokney", "given": "Assaf", "initials": "A"}, {"family": "Ron", "given": "Merav", "initials": "M"}, {"family": "Scott", "given": "Kevin J", "initials": "KJ"}, {"family": "Sheppard", "given": "Carmen L", "initials": "CL"}, {"family": "Siira", "given": "Lotta", "initials": "L"}, {"family": "Skoczy\u0144ska", "given": "Anna", "initials": "A"}, {"family": "Sloan", "given": "Monica", "initials": "M"}, {"family": "Slotved", "given": "Hans Christian", "initials": "HC"}, {"family": "Smith", "given": "Andrew J", "initials": "AJ"}, {"family": "Song", "given": "Joon Young", "initials": "JY"}, {"family": "Taha", "given": "Muhamed Kheir", "initials": "MK"}, {"family": "Toropainen", "given": "Maija", "initials": "M"}, {"family": "Tsang", "given": "Dominic", "initials": "D"}, {"family": "Vainio", "given": "Anni", "initials": "A"}, {"family": "van Sorge", "given": "Nina M", "initials": "NM"}, {"family": "Varon", "given": "Emmanuelle", "initials": "E"}, {"family": "Vlach", "given": "Jiri", "initials": "J"}, {"family": "Vogel", "given": "Ulrich", "initials": "U"}, {"family": "Vohrnova", "given": "Sandra", "initials": "S"}, {"family": "von Gottberg", "given": "Anne", "initials": "A"}, {"family": "Zanella", "given": "Rosemeire C", "initials": "RC"}, {"family": "Zhou", "given": "Fei", "initials": "F"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "The Lancet Digital Health", "issn": "2589-7500", "issn-l": null, "volume": "3", "issue": "6", "pages": "e360-e370"}, "abstract": "Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis, which are typically transmitted via respiratory droplets, are leading causes of invasive diseases, including bacteraemic pneumonia and meningitis, and of secondary infections subsequent to post-viral respiratory disease. The aim of this study was to investigate the incidence of invasive disease due to these pathogens during the early months of the COVID-19 pandemic.\r\n\r\nIn this prospective analysis of surveillance data, laboratories in 26 countries and territories across six continents submitted data on cases of invasive disease due to S pneumoniae, H influenzae, and N meningitidis from Jan 1, 2018, to May, 31, 2020, as part of the Invasive Respiratory Infection Surveillance (IRIS) Initiative. Numbers of weekly cases in 2020 were compared with corresponding data for 2018 and 2019. Data for invasive disease due to Streptococcus agalactiae, a non-respiratory pathogen, were collected from nine laboratories for comparison. The stringency of COVID-19 containment measures was quantified using the Oxford COVID-19 Government Response Tracker. Changes in population movements were assessed using Google COVID-19 Community Mobility Reports. Interrupted time-series modelling quantified changes in the incidence of invasive disease due to S pneumoniae, H influenzae, and N meningitidis in 2020 relative to when containment measures were imposed.\r\n\r\n27 laboratories from 26 countries and territories submitted data to the IRIS Initiative for S pneumoniae (62 837 total cases), 24 laboratories from 24 countries submitted data for H influenzae (7796 total cases), and 21 laboratories from 21 countries submitted data for N meningitidis (5877 total cases). All countries and territories had experienced a significant and sustained reduction in invasive diseases due to S pneumoniae, H influenzae, and N meningitidis in early 2020 (Jan 1 to May 31, 2020), coinciding with the introduction of COVID-19 containment measures in each country. By contrast, no significant changes in the incidence of invasive S agalactiae infections were observed. Similar trends were observed across most countries and territories despite differing stringency in COVID-19 control policies. The incidence of reported S pneumoniae infections decreased by 68% at 4 weeks (incidence rate ratio 0\u00b732 [95% CI 0\u00b727-0\u00b737]) and 82% at 8 weeks (0\u00b718 [0\u00b714-0\u00b723]) following the week in which significant changes in population movements were recorded.\r\n\r\nThe introduction of COVID-19 containment policies and public information campaigns likely reduced transmission of S pneumoniae, H influenzae, and N meningitidis, leading to a significant reduction in life-threatening invasive diseases in many countries worldwide.\r\n\r\nWellcome Trust (UK), Robert Koch Institute (Germany), Federal Ministry of Health (Germany), Pfizer, Merck, Health Protection Surveillance Centre (Ireland), SpID-Net project (Ireland), European Centre for Disease Prevention and Control (European Union), Horizon 2020 (European Commission), Ministry of Health (Poland), National Programme of Antibiotic Protection (Poland), Ministry of Science and Higher Education (Poland), Agencia de Salut P\u00fablica de Catalunya (Spain), Sant Joan de Deu Foundation (Spain), Knut and Alice Wallenberg Foundation (Sweden), Swedish Research Council (Sweden), Region Stockholm (Sweden), Federal Office of Public Health of Switzerland (Switzerland), and French Public Health Agency (France).", "doi": "10.1016/s2589-7500(21)00077-7", "pmid": "34045002", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2589-7500(21)00077-7"}, {"db": "URL", "key": "https://github.com/brueggemann-lab/iris-ldh-2020/tree/main/code", "description": "Data processing, visualisation, analysis code"}], "notes": [], "created": "2021-05-29T15:25:23.212Z", "modified": "2021-12-22T12:47:24.255Z"}, {"entity": "publication", "iuid": "6a107e18fba94c87bfcf92e94c907307", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a107e18fba94c87bfcf92e94c907307.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a107e18fba94c87bfcf92e94c907307"}}, "title": "Cardiovascular-related deaths at the beginning of the COVID-19 outbreak: a prospective analysis based on the UK Biobank", "authors": [{"family": "Wang", "given": "Junren", "initials": "J"}, {"family": "Zhu", "given": "Jianwei", "initials": "J"}, {"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Sun", "given": "Yajing", "initials": "Y"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "Qu", "given": "Yuanyuan", "initials": "Y"}, {"family": "Valdimarsdottir", "given": "Unnur", "initials": "U"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "6", "pages": "e046931"}, "abstract": null, "doi": "10.1136/bmjopen-2020-046931", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-08T08:44:53.007Z", "modified": "2021-06-08T08:45:06.122Z"}, {"entity": "publication", "iuid": "882b84f8d9014804bb645ecafcfd3ced", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/882b84f8d9014804bb645ecafcfd3ced.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/882b84f8d9014804bb645ecafcfd3ced"}}, "title": "COVID-19 in immunocompromised populations: implications for prognosis and repurposing of immunotherapies.", "authors": [{"family": "Goldman", "given": "Jason D", "initials": "JD", "orcid": "0000-0002-3825-6832", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87e08520608949ac9fa338a38550098b.json"}}, {"family": "Robinson", "given": "Philip C", "initials": "PC", "orcid": "0000-0002-3156-3418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/950b622d31724172817ccde09902d215.json"}}, {"family": "Uldrick", "given": "Thomas S", "initials": "TS", "orcid": "0000-0001-6959-0924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69d5a4f766394718943dea6300513856.json"}}, {"family": "Ljungman", "given": "Per", "initials": "P", "orcid": "0000-0002-8281-3245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4546eb504184683ab712eee858ea9cb.json"}}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "J Immunother Cancer", "issn": "2051-1426", "volume": "9", "issue": "6", "issn-l": null}, "abstract": "SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. COVID-19 has highly variable disease severity and a bimodal course characterized by acute respiratory viral infection followed by hyperinflammation in a subset of patients with severe disease. This immune dysregulation is characterized by lymphocytopenia, elevated levels of plasma cytokines and proliferative and exhausted T cells, among other dysfunctional cell types. Immunocompromised persons often fare worse in the context of acute respiratory infections, but preliminary data suggest this may not hold true for COVID-19. In this review, we explore the effect of SARS-CoV-2 infection on mortality in four populations with distinct forms of immunocompromise: (1) persons with hematological malignancies (HM) and hematopoietic stem cell transplant (HCT) recipients; (2) solid organ transplant recipients (SOTRs); (3) persons with rheumatological diseases; and (4) persons living with HIV (PLWH). For each population, key immunological defects are described and how these relate to the immune dysregulation in COVID-19. Next, outcomes including mortality after SARS-CoV-2 infection are described for each population, giving comparisons to the general population of age-matched and comorbidity-matched controls. In these four populations, iatrogenic or disease-related immunosuppression is not clearly associated with poor prognosis in HM, HCT, SOTR, rheumatological diseases, or HIV. However, certain individual immunosuppressants or disease states may be associated with harmful or beneficial effects, including harm from severe CD4 lymphocytopenia in PLWH and possible benefit to the calcineurin inhibitor ciclosporin in SOTRs, or tumor necrosis factor-\u03b1 inhibitors in persons with rheumatic diseases. Lastly, insights gained from clinical and translational studies are explored as to the relevance for repurposing of immunosuppressive host-directed therapies for the treatment of hyperinflammation in COVID-19 in the general population.", "doi": "10.1136/jitc-2021-002630", "pmid": "34117116", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jitc-2021-002630"}], "notes": [], "created": "2021-06-14T06:33:51.825Z", "modified": "2021-06-14T06:33:53.045Z"}, {"entity": "publication", "iuid": "020205cca7b44ead9df18e321fb13dd1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/020205cca7b44ead9df18e321fb13dd1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/020205cca7b44ead9df18e321fb13dd1"}}, "title": "Autoimmune Encephalitis Presenting With Malignant Catatonia in a 40-Year-Old Male Patient With COVID-19.", "authors": [{"family": "Mulder", "given": "Jan", "initials": "J"}, {"family": "Feresiadou", "given": "Amalia", "initials": "A"}, {"family": "F\u00e4llmar", "given": "David", "initials": "D"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "Rasmusson", "given": "Annica", "initials": "A"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Cunningham", "given": "Janet L", "initials": "JL"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Am J Psychiatry", "issn": "1535-7228", "volume": "178", "issue": "6", "pages": "485-489", "issn-l": null}, "abstract": null, "doi": "10.1176/appi.ajp.2020.20081236", "pmid": "34154381", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:23:09.280Z", "modified": "2021-06-28T18:23:09.306Z"}, {"entity": "publication", "iuid": "228ce5c33a6e43868dc6d99a1b519861", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/228ce5c33a6e43868dc6d99a1b519861.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/228ce5c33a6e43868dc6d99a1b519861"}}, "title": "Author Correction: Attributes and predictors of long COVID.", "authors": [{"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Murray", "given": "Benjamin", "initials": "B", "orcid": "0000-0002-2413-923X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebec738df0224bf4874fd6c08fd23fae.json"}}, {"family": "Varsavsky", "given": "Thomas", "initials": "T"}, {"family": "Graham", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-4170-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f5f4e19812a46ed9e873732ec25e28d.json"}}, {"family": "Penfold", "given": "Rose S", "initials": "RS"}, {"family": "Bowyer", "given": "Ruth C", "initials": "RC", "orcid": "0000-0002-6941-8160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eebaf361c184499ca6729aa60cc0af3d.json"}}, {"family": "Pujol", "given": "Joan Capdevila", "initials": "JC", "orcid": "0000-0003-1658-1076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60965a027a4b4d048728748f09c98594.json"}}, {"family": "Klaser", "given": "Kerstin", "initials": "K"}, {"family": "Antonelli", "given": "Michela", "initials": "M"}, {"family": "Canas", "given": "Liane S", "initials": "LS"}, {"family": "Molteni", "given": "Erika", "initials": "E", "orcid": "0000-0001-7773-8140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9aed1fbe444b48d4bfacb12050953c8e.json"}}, {"family": "Modat", "given": "Marc", "initials": "M"}, {"family": "Jorge Cardoso", "given": "M", "initials": "M", "orcid": "0000-0003-1284-2558", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0ed3abec67644e186650e1d1dcbbe0b.json"}}, {"family": "May", "given": "Anna", "initials": "A"}, {"family": "Ganesh", "given": "Sajaysurya", "initials": "S", "orcid": "0000-0002-3720-4176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6dbf91180806442082ce6732c1b75923.json"}}, {"family": "Davies", "given": "Richard", "initials": "R", "orcid": "0000-0003-2050-3994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b82cc92615f462d9af0153a6fb94fde.json"}}, {"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Drew", "given": "David A", "initials": "DA", "orcid": "0000-0002-8813-0816", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd3a2cffdc104f18b8684cf4f27d68b2.json"}}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Merino", "given": "Jordi", "initials": "J", "orcid": "0000-0001-8312-1438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12ab049914a542b39affcfb4196861d2.json"}}, {"family": "Tsereteli", "given": "Neli", "initials": "N"}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f34c0d3602439abe6096293c7c732d.json"}}, {"family": "Gomez", "given": "Maria F", "initials": "MF", "orcid": "0000-0001-6210-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e09e37219c4f42c8a7b3a982da523859.json"}}, {"family": "Duncan", "given": "Emma L", "initials": "EL"}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874802ae65824a90ba50eabdeabb8356.json"}}, {"family": "Williams", "given": "Frances M K", "initials": "FMK", "orcid": "0000-0002-2998-2744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87a6db988c2e421f81fce7773436aefa.json"}}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74cf1f7094744ee289fa5df041e7cb5b.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-7284-6767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeefbf47fd384d5390109fe1a903bd18.json"}}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Ourselin", "given": "Sebastien", "initials": "S", "orcid": "0000-0002-5694-5340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74c7b9b1633144879042d198c7205656.json"}}, {"family": "Spector", "given": "Tim", "initials": "T", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}], "type": "published erratum", "published": "2021-06-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956", "volume": "27", "issue": "6", "pages": "1116"}, "abstract": null, "doi": "10.1038/s41591-021-01361-2", "pmid": "34045738", "labels": {"Type: Other": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-021-01361-2"}], "notes": [], "created": "2021-05-29T15:23:39.445Z", "modified": "2023-06-19T15:28:16.046Z"}, {"entity": "publication", "iuid": "95a6e8fb6e3047ffad0f3a0583b05a01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95a6e8fb6e3047ffad0f3a0583b05a01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95a6e8fb6e3047ffad0f3a0583b05a01"}}, "title": "Association Between Collagenous and Lymphocytic Colitis and Risk of Severe Coronavirus Disease 2019", "authors": [{"family": "Khalili", "given": "Hamed", "initials": "H", "orcid": "0000-0002-7956-6941", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e248e3e76594014af041c8e62cfcfc6.json"}}, {"family": "Zheng", "given": "Tenghao", "initials": "T"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Larsson", "given": "Emma", "initials": "E"}, {"family": "Munch", "given": "Andreas", "initials": "A"}, {"family": "Sjoberg", "given": "Klas", "initials": "K"}, {"family": "Almer", "given": "Sven", "initials": "S"}, {"family": "Vigren", "given": "Lina", "initials": "L"}, {"family": "Janczewska", "given": "Izabella", "initials": "I"}, {"family": "Ohlsson", "given": "Bodil", "initials": "B"}, {"family": "Bresso", "given": "Francesca", "initials": "F"}, {"family": "Mellander", "given": "Maire Rose", "initials": "MR"}, {"family": "Ol\u00e9n", "given": "Ola", "initials": "O"}, {"family": "Roelstraete", "given": "Bjorn", "initials": "B"}, {"family": "Franke", "given": "Andre", "initials": "A"}, {"family": "Simon", "given": "Tracey G", "initials": "TG"}, {"family": "D'Amato", "given": "Mauro", "initials": "M"}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "Gastroenterology", "issn": "1528-0012", "issn-l": null, "volume": "160", "issue": "7", "pages": "2585-2587.e3"}, "abstract": null, "doi": "10.1053/j.gastro.2021.02.029", "pmid": "33610527", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0016-5085(21)00417-0"}], "notes": [], "created": "2021-02-22T11:50:13.123Z", "modified": "2021-06-18T12:17:26.842Z"}, {"entity": "publication", "iuid": "e9633a955a014394a5c1b34238b492cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e9633a955a014394a5c1b34238b492cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e9633a955a014394a5c1b34238b492cf"}}, "title": "Are in-person scientific conferences dead or alive?", "authors": [{"family": "Dua", "given": "Nick", "initials": "N"}, {"family": "Fyrenius", "given": "Mattias", "initials": "M"}, {"family": "Johnson", "given": "Deborah L", "initials": "DL"}, {"family": "Moos", "given": "Walter H", "initials": "WH", "orcid": "0000-0001-7244-811X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc7341bafa42423e8d16afd76b97ed64.json"}}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "FASEB Bioadv", "issn": "2573-9832", "volume": "3", "issue": "6", "pages": "420-427", "issn-l": null}, "abstract": "Given the disruption caused by the COVID-19 pandemic, life as we knew it has been turned upside down, but the need for science to go on has never been stronger. In the realm of scientific conferences, with the requirement for social distancing, the importance of wearing face coverings, and travel restrictions, only virtual meetings have been possible during the pandemic. But many are asking: What is the new post-pandemic normal likely to be? Do we still want to have in-person meetings when the restrictions are eased? Assuming we do, when will they be possible again, and under what conditions? Regardless of what the benefits of virtual symposia might be, are they here to stay? These questions, and many more that are being asked around the world today, are the subject of this perspective. Herein, we attempt to provide useful context and insight into where scientific meetings have been, where they are today, where they are going, and how they will get there. Our conclusion is that the pandemic has created an accelerated opportunity to make the world of future scientific conferences better in a \"both/and\" collaborative in-person/virtual scenario, not the more limited \"pick one\" choice.", "doi": "10.1096/fba.2020-00139", "pmid": "34124597", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "FBA21205"}, {"db": "pmc", "key": "PMC8171307"}], "notes": [], "created": "2021-06-17T07:40:58.715Z", "modified": "2021-06-17T07:40:58.766Z"}, {"entity": "publication", "iuid": "0cc8de28a8744ab880da9073a0059bab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0cc8de28a8744ab880da9073a0059bab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0cc8de28a8744ab880da9073a0059bab"}}, "title": "Antimicrobial resistance research in a post-pandemic world: Insights on antimicrobial resistance research in the COVID-19 pandemic", "authors": [{"family": "Rodr\u00edguez-Ba\u00f1o", "given": "Jes\u00fas", "initials": "J"}, {"family": "Rossolini", "given": "Gian Maria", "initials": "GM"}, {"family": "Schultsz", "given": "Constance", "initials": "C"}, {"family": "Tacconelli", "given": "Evelina", "initials": "E"}, {"family": "Murthy", "given": "Srinivas", "initials": "S"}, {"family": "Ohmagari", "given": "Norio", "initials": "N"}, {"family": "Holmes", "given": "Alison", "initials": "A"}, {"family": "Bachmann", "given": "Till", "initials": "T"}, {"family": "Goossens", "given": "Herman", "initials": "H"}, {"family": "Canton", "given": "Rafael", "initials": "R"}, {"family": "Roberts", "given": "Adam P", "initials": "AP"}, {"family": "Henriques-Normark", "given": "Birgitta", "initials": "B"}, {"family": "Clancy", "given": "Cornelius J", "initials": "CJ"}, {"family": "Huttner", "given": "Benedikt", "initials": "B"}, {"family": "Fagerstedt", "given": "Patriq", "initials": "P"}, {"family": "Lahiri", "given": "Shawon", "initials": "S"}, {"family": "Kaushic", "given": "Charu", "initials": "C"}, {"family": "Hoffman", "given": "Steven J", "initials": "SJ"}, {"family": "Warren", "given": "Margo", "initials": "M"}, {"family": "Zoubiane", "given": "Ghada", "initials": "G"}, {"family": "Essack", "given": "Sabiha", "initials": "S"}, {"family": "Laxminarayan", "given": "Ramanan", "initials": "R"}, {"family": "Plant", "given": "Laura", "initials": "L"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "Journal of Global Antimicrobial Resistance", "issn": "2213-7165", "volume": "25", "issue": null, "pages": "5-7", "issn-l": null}, "abstract": "Antimicrobial resistance must be recognised as a global societal priority - even in the face of the worldwide challenge of the COVID-19 pandemic. COVID-19 has illustrated the vulnerability of our healthcare systems in co-managing multiple infectious disease threats as resources for monitoring and detecting, and conducting research on antimicrobial resistance have been compromised during the pandemic. The increased awareness of the importance of infectious diseases, clinical microbiology and infection control and lessons learnt during the COVID-19 pandemic should be exploited to ensure that emergence of future infectious disease threats, including those related to AMR, are minimised. Harnessing the public understanding of the relevance of infectious diseases towards the long-term pandemic of AMR could have major implications for promoting good practices about the control of AMR transmission.", "doi": "10.1016/j.jgar.2021.02.013", "pmid": "33662647", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-7165(21)00045-X"}, {"db": "pmc", "key": "PMC7919515"}], "notes": [], "created": "2021-03-06T10:20:21.390Z", "modified": "2021-12-22T12:47:00.874Z"}, {"entity": "publication", "iuid": "9b8650bb534049239347a549570038aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b8650bb534049239347a549570038aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b8650bb534049239347a549570038aa"}}, "title": "A unique view of SARS-COV-2 through the lens of ORF8 protein", "authors": [{"family": "Hassan", "given": "Sk Sarif", "initials": "SS"}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA"}, {"family": "Panda", "given": "Pritam Kumar", "initials": "PK"}, {"family": "Ghosh", "given": "Shinjini", "initials": "S"}, {"family": "Attrish", "given": "Diksha", "initials": "D"}, {"family": "Choudhury", "given": "Pabitra Pal", "initials": "PP"}, {"family": "Seyran", "given": "Murat", "initials": "M"}, {"family": "Pizzol", "given": "Damiano", "initials": "D"}, {"family": "Adadi", "given": "Parise", "initials": "P"}, {"family": "Abd El-Aziz", "given": "Tarek Mohamed", "initials": "TM"}, {"family": "Soares", "given": "Antonio", "initials": "A"}, {"family": "Kandimalla", "given": "Ramesh", "initials": "R"}, {"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Lal", "given": "Amos", "initials": "A"}, {"family": "Azad", "given": "Gajendra Kumar", "initials": "GK"}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN"}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Baetas-da-Cruz", "given": "Wagner", "initials": "W"}, {"family": "Uhal", "given": "Bruce D", "initials": "BD"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Chauhan", "given": "Gaurav", "initials": "G"}, {"family": "Barh", "given": "Debmalya", "initials": "D"}, {"family": "Redwan", "given": "Elrashdy M", "initials": "EM"}, {"family": "Dayhoff", "given": "Guy W", "initials": "GW"}, {"family": "Bazan", "given": "Nicolas G", "initials": "NG"}, {"family": "Serrano-Aroca", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "El-Demerdash", "given": "Amr", "initials": "A"}, {"family": "Mishra", "given": "Yogendra K", "initials": "YK"}, {"family": "Palu", "given": "Giorgio", "initials": "G"}, {"family": "Takayama", "given": "Kazuo", "initials": "K"}, {"family": "Brufsky", "given": "Adam M", "initials": "AM"}, {"family": "Tambuwala", "given": "Murtaza M", "initials": "MM"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "Computers in Biology and Medicine", "issn": "0010-4825", "issn-l": null, "volume": "133", "issue": null, "pages": "104380"}, "abstract": null, "doi": "10.1016/j.compbiomed.2021.104380", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-20T17:50:03.288Z", "modified": "2021-06-30T05:18:19.633Z"}, {"entity": "publication", "iuid": "76c6675ecd144263b48025aceb887ab0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76c6675ecd144263b48025aceb887ab0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76c6675ecd144263b48025aceb887ab0"}}, "title": "A collection of the novel coronavirus (COVID-19) detection assays, issues, and challenges.", "authors": [{"family": "Rezvani Ghomi", "given": "Erfan", "initials": "E"}, {"family": "Khosravi", "given": "Fatemeh", "initials": "F"}, {"family": "Mohseni-M", "given": "Ali", "initials": "A"}, {"family": "Nourbakhsh", "given": "Nooshin", "initials": "N"}, {"family": "Haji Mohammad Hoseini", "given": "Mahsa", "initials": "M"}, {"family": "Singh", "given": "Sunpreet", "initials": "S"}, {"family": "Hedenqvist", "given": "Mikael S", "initials": "MS"}, {"family": "Ramakrishna", "given": "Seeram", "initials": "S"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "issn-l": null, "volume": "7", "issue": "6", "pages": "e07247"}, "abstract": "The global pandemic of COVID-19 has rapidly increased the number of infected cases as well as asymptomatic individuals in many, if not all the societies around the world. This issue increases the demand for accurate and rapid detection of SARS-CoV-2. While accurate and rapid detection is critical for diagnosing SARS-CoV-2, the appropriate course of treatment must be chosen to help patients and prevent its further spread. Testing platform accuracy with high sensitivity and specificity for SARS-CoV-2 is equally important for clinical, regional, and global arenas to mitigate secondary transmission rounds. The objective of this article is to compare the current detection technology and introduce the most accurate and rapid ones that are suitable for pandemic circumstances. Hence, the importance of rapid detection in societies is discussed initially. Following this, the current technology for rapid detection of SARS-CoV-2 is explained and classified into three different categories: nucleic acid-based, protein-based, and point of care (PoC) detection testing. Then, the current issues for diagnostic procedures in laboratories are discussed. Finally, the role of new technologies in countering COVID-19 is also introduced to assist researchers in the development of accurate and timely detection of coronaviruses. As coronavirus continues to affect human lives in a detrimental manner, the development of rapid and accurate virus detection methods could promote COVID-19 diagnosis accessible to both individuals and the mass population at patient care. In this regard, rRT-PCR and multiplex RT-PCR detection techniques hold promise.", "doi": "10.1016/j.heliyon.2021.e07247", "pmid": "34124407", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)01350-5"}, {"db": "pmc", "key": "PMC8179727"}], "notes": [], "created": "2021-06-17T07:31:39.185Z", "modified": "2021-06-17T07:31:53.661Z"}, {"entity": "publication", "iuid": "f6daf7ba0a6245ef80f67745d470754a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6daf7ba0a6245ef80f67745d470754a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6daf7ba0a6245ef80f67745d470754a"}}, "title": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process", "authors": [{"family": "Noske", "given": "G D", "initials": "GD"}, {"family": "Nakamura", "given": "A M", "initials": "AM"}, {"family": "Gawriljuk", "given": "V O", "initials": "VO"}, {"family": "Fernandes", "given": "R S", "initials": "RS"}, {"family": "M. A. Lima", "given": "G", "initials": "G"}, {"family": "V. D. Rosa", "given": "H", "initials": "H"}, {"family": "Pereira", "given": "H D", "initials": "HD"}, {"family": "C. M. Zeri", "given": "A", "initials": "A"}, {"family": "A. F. Z. Nascimento", "given": "A", "initials": "A"}, {"family": "C. L. C. Freire", "given": "M", "initials": "M"}, {"family": "Fearon", "given": "D", "initials": "D"}, {"family": "Douangamath", "given": "A", "initials": "A"}, {"family": "von Delft", "given": "F", "initials": "F"}, {"family": "Oliva", "given": "G", "initials": "G"}, {"family": "Godoy", "given": "A S", "initials": "AS"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "Journal of Molecular Biology", "issn": "0022-2836", "pages": "167118", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jmb.2021.167118", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "PDB", "key": "7KFI", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7MBG,", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7KPH", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7N6N", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7LFE", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7LDX", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7LFP", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7KVL", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7N5Z", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7KVR", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}], "notes": [], "created": "2021-06-28T18:07:33.728Z", "modified": "2021-11-18T13:25:03.256Z"}, {"entity": "publication", "iuid": "31a3255454da4e6e98b7717709f33eca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/31a3255454da4e6e98b7717709f33eca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/31a3255454da4e6e98b7717709f33eca"}}, "title": "Political stigma of communicable diseases in complex emergencies.", "authors": [{"family": "Bellizzi", "given": "Saverio", "initials": "S"}, {"family": "Bassat", "given": "Quique", "initials": "Q"}, {"family": "Pichierri", "given": "Giuseppe", "initials": "G"}, {"family": "Cegolon", "given": "Luca", "initials": "L"}, {"family": "Panu Napodano", "given": "Catello Mario", "initials": "CM"}, {"family": "Farina", "given": "Gabriele", "initials": "G"}, {"family": "Murgia", "given": "Paola", "initials": "P"}, {"family": "Ali Maher", "given": "Osama", "initials": "O"}], "type": "journal article", "published": "2021-05-31", "journal": {"title": "J Infect Dev Ctries", "issn": "1972-2680", "volume": "15", "issue": "5", "pages": "747-748", "issn-l": null}, "abstract": null, "doi": "10.3855/jidc.14056", "pmid": "34106901", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-06-10T10:14:27.899Z", "modified": "2021-06-10T10:14:27.909Z"}, {"entity": "publication", "iuid": "81ad5751a2ab4d1d982c75035dc761e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/81ad5751a2ab4d1d982c75035dc761e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/81ad5751a2ab4d1d982c75035dc761e2"}}, "title": "More green, less lonely? A longitudinal cohort study.", "authors": [{"family": "Astell-Burt", "given": "Thomas", "initials": "T"}, {"family": "Hartig", "given": "Terry", "initials": "T"}, {"family": "Eckermann", "given": "Simon", "initials": "S"}, {"family": "Nieuwenhuijsen", "given": "Mark", "initials": "M"}, {"family": "McMunn", "given": "Anne", "initials": "A"}, {"family": "Frumkin", "given": "Howard", "initials": "H"}, {"family": "Feng", "given": "Xiaoqi", "initials": "X"}], "type": "journal article", "published": "2021-05-31", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "issn-l": "0300-5771", "volume": null, "issue": null, "pages": null}, "abstract": "Urban greening may reduce loneliness by offering opportunities for solace, social reconnection and supporting processes such as stress relief. We (i) assessed associations between residential green space and cumulative incidence of, and relief from, loneliness over 4 years; and (ii) explored contingencies by age, sex, disability and cohabitation status.\r\n\r\nMultilevel logistic regressions of change in loneliness status in 8049 city-dwellers between 2013 (baseline) and 2017 (follow-up) in the Household, Income and Labour Dynamics in Australia study. Associations with objectively measured discrete green-space buffers (e.g. parks) (<400, <800 and <1600 m) were adjusted for age, sex, disability, cohabitation status, children and socio-economic variables. Results were translated into absolute risk reductions in loneliness per 10% increase in urban greening.\r\n\r\nThe absolute risk of loneliness rose from 15.9% to 16.9% over the 4 years; however, a 10% increase in urban greening within 1.6 km was associated with lower cumulative incident loneliness [odds ratio (OR) = 0.927, 95% confidence interval (CI) = 0.862 to 0.996; absolute risk reduction = 0.66%]. Stronger association was observed for people living alone (OR = 0.828, 95% CI = 0.725 to 0.944). In comparison to people with <10% green space, the ORs for cumulative incident loneliness were 0.833 (95% CI = 0.695 to 0.997), 0.790 (95% CI = 0.624 to 1.000) and 0.736 (95% CI = 0.549 to 0.986) for 10-20%, 20-30% and >30% green space, respectively. Compared with the <10% green-space reference group with 13.78% incident loneliness over 4 years and conservatively assuming no impact on incident loneliness, associations translated into absolute risk reductions of 1.70%, 2.26% and 2.72% within populations with 10-20%, 20-30% and >30% green space, respectively. These associations were stronger again for people living alone, with 10-20% (OR = 0.608, 95% CI = 0.448 to 0.826), 20-30% (OR = 0.649, 95% CI = 0.436 to 0.966) and >30% (OR = 0.480, 95% CI = 0.278 to 0.829) green space within 1600 m. No age, sex or disability-related contingencies, associations with green space within 400 or 800 m or relief from loneliness reported at baseline were observed.\r\n\r\nA lower cumulative incidence of loneliness was observed among people with more green space within 1600 m of home, especially for people living alone. Potential biopsychosocial mechanisms warrant investigation.", "doi": "10.1093/ije/dyab089", "pmid": "34057994", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "6289969"}], "notes": [], "created": "2021-06-04T11:24:52.062Z", "modified": "2022-11-23T09:00:05.599Z"}, {"entity": "publication", "iuid": "db2bc2a48698482fac8899fdac4646d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db2bc2a48698482fac8899fdac4646d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db2bc2a48698482fac8899fdac4646d5"}}, "title": "Evaluation of Production Lots of a Rapid Point-of-Care Lateral Flow Serological Test Intended for Identification of IgM and IgG against the N-Terminal Part of the Spike Protein (S1) of SARS-CoV-2.", "authors": [{"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Kolstad", "given": "Linda", "initials": "L"}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "journal article", "published": "2021-05-31", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "13", "issue": "6", "pages": null}, "abstract": "The potential of rapid point-of-care (POC) tests has been subject of doubt due to an eventual risk of production errors. The aim was therefore to evaluate the two separate production lots of a commercial POC lateral flow test, intended for the detection of IgM and IgG against the SARS-CoV-2 spike protein (S1). Control samples consisted of serum from individuals with confirmed SARS-CoV-2 infection and pre-COVID-19 negative sera gathered from a biobank. The presence of anti-S1 IgM/IgG in the sera was verified by an in-house Luminex-based serological assay (COVID-19 SIA). One hundred samples were verified as positive for anti-S1 IgG and 74 for anti-S1 IgM. Two hundred samples were verified as negative for anti-S1 IgM/IgG. For the two lots of the POC-test, the sensitivities were 93.2% and 87.8% for IgM and 93.0% and 100% for IgG. The specificities were 100% for IgM and 99.5% for IgG. The positive predictive value was 100% for IgM and 98.9% and 99.0% for IgG. The negative predictive value was 97.6% and 95.7% for IgM, and 96.6% and 100% for IgG. The evaluated POC-test is suitable to assess anti-SARS-CoV-2 S1 IgM and IgG, as a measure of previous virus exposure on an individual level. The external validation of separate lots of rapid POC-tests is encouraged to ensure high sensitivity before market introduction.", "doi": "10.3390/v13061043", "pmid": "34072890", "labels": {"Type: Journal article": null, "Funder: H2020": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Category: Health": null, "Research Area: High-throughput and high-content serology": null}, "xrefs": [{"db": "pii", "key": "v13061043"}], "notes": [], "created": "2021-06-04T11:16:38.767Z", "modified": "2021-08-25T08:16:14.306Z"}, {"entity": "publication", "iuid": "392c272d9fdc407b9613f69a4a167c9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/392c272d9fdc407b9613f69a4a167c9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/392c272d9fdc407b9613f69a4a167c9c"}}, "title": "Implementing Public Health Strategies-The Need for Educational Initiatives: A Systematic Review.", "authors": [{"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}, {"family": "Dulebenets", "given": "Maxim A", "initials": "MA"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}], "type": "journal article", "published": "2021-05-30", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "11", "issn-l": null}, "abstract": "In the absence of a specific treatment or vaccines, public health strategies are the main measures to use in the initial stages of a pandemic to allow surveillance of infectious diseases. During the ongoing global pandemic of coronavirus disease 2019 (COVID-19), several countries initiated various public health strategies, such as contact tracing and quarantine. The present study aims to conduct a systematic literature review to identify the presence of educational initiatives that promote the implementation of public health strategies before public health emergencies, with a special focus on contact tracing applications. Using Science Direct, PubMed, Scopus, and Gothenburg University search engines, all published scientific articles were included, while conference, reports, and non-scientific papers were excluded. The outcomes of the reviewed studies indicate that the effective implementation of public health strategies depends on the peoples' willingness to participate and collaborate with local authorities. Several factors may influence such willingness, of which ethical, psychological, and practical factors seem to be the most important and frequently discussed. Moreover, individual willingness and readiness of a community may also vary based on the acquired level of knowledge about the incident and its cause and available management options. Educational initiatives, proper communication, and timely information at the community level were found to be the necessary steps to counteract misinformation and to promote a successful implementation of public health strategies and attenuate the effects of a pandemic. The systematic review conducted as a part of this study would benefit the relevant stakeholders and policy makers and assist with effective designing and implementation.", "doi": "10.3390/ijerph18115888", "pmid": "34070882", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijerph18115888"}], "notes": [], "created": "2021-06-04T11:17:15.017Z", "modified": "2021-06-04T11:18:07.146Z"}, {"entity": "publication", "iuid": "68875bb1de464d308d1429a8cde63cf1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68875bb1de464d308d1429a8cde63cf1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68875bb1de464d308d1429a8cde63cf1"}}, "title": "The healthier healthcare management models for COVID-19.", "authors": [{"family": "Mishra", "given": "Anshuman", "initials": "A"}, {"family": "Basumallick", "given": "Srijita", "initials": "S"}, {"family": "Lu", "given": "Albert", "initials": "A"}, {"family": "Chiu", "given": "Helen", "initials": "H"}, {"family": "Shah", "given": "Mohammad A", "initials": "MA"}, {"family": "Shukla", "given": "Yogesh", "initials": "Y"}, {"family": "Tiwari", "given": "Ashutosh", "initials": "A"}], "type": "journal article", "published": "2021-05-29", "journal": {"title": "J Infect Public Health", "issn": "1876-035X", "issn-l": null, "volume": "14", "issue": "7", "pages": "927-937"}, "abstract": "The worldwide pandemic situation of COVID-19 generates a situation in which healthcare resources such as diagnostic kits, drugs and basic healthcare infrastructure were on shortage throughout the period, along with negative impact on socio-economic system. Standardized public healthcare models were missing in pandemic situation, covering from hospitalized patient care to local resident's healthcare managements in terms of monitoring, assess to diagnosis and medicines. This exploratory and intervention-based study with the objective of proposing COVID-19 Care Management Model representing comprehensive care of society including patients (COVID-19 and other diseases) and healthy subjects under integrated framework of healthier management model. Shifting policy towards technology-oriented models with well-aligned infrastructure can achieve better outcomes in COVID-19 prevention and care. The planned development of technical healthcare models for prognosis and improved treatment outcomes that take into account not only genomics, proteomics, nanotechnology, materials science perspectives but also the possible contribution of advanced digital technologies is best strategies for early diagnosis and infections control. In view of current pandemic, a Healthier Healthcare Management Model is proposed here as a source of standardized care having technology support, medical consultation, along with public health model of sanitization, distancing and contact less behaviours practices. Effective healthcare managements have been the main driver of healthier society where, positive action at identified research, technology and management segment more specifically public health, patient health, technology selection and political influence has great potential to enhanced the global response to COVID-19. The implementation of such practices will deliver effective diagnosis and control mechanism and make healthier society.", "doi": "10.1016/j.jiph.2021.05.014", "pmid": "34119847", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1876-0341(21)00131-3"}], "notes": [], "created": "2021-06-14T14:22:40.557Z", "modified": "2021-06-17T07:26:04.930Z"}, {"entity": "publication", "iuid": "d4931e50718e4eeb962ecdc1c2af67ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4931e50718e4eeb962ecdc1c2af67ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4931e50718e4eeb962ecdc1c2af67ff"}}, "title": "Immunogenicity of a first dose of mRNA- or vector-based SARS-CoV-2 vaccination in dialysis patients: a multicenter prospective observational pilot study.", "authors": [{"family": "Lesny", "given": "Paul", "initials": "P"}, {"family": "Anderson", "given": "Mark", "initials": "M"}, {"family": "Cloherty", "given": "Gavin", "initials": "G"}, {"family": "Stec", "given": "Michael", "initials": "M"}, {"family": "Haase-Fielitz", "given": "Anja", "initials": "A"}, {"family": "Haarhaus", "given": "Mathias", "initials": "M"}, {"family": "Santos", "given": "Carla", "initials": "C"}, {"family": "Lucas", "given": "Carlos", "initials": "C"}, {"family": "Macario", "given": "Fernando", "initials": "F"}, {"family": "Haase", "given": "Michael", "initials": "M"}], "type": "letter", "published": "2021-05-29", "journal": {"title": "J Nephrol", "issn": "1724-6059", "volume": null, "issue": null, "issn-l": null}, "abstract": "Dialysis patients are at risk for lower SARS-CoV-2-vaccine immunogenicity than the normal population. We assessed immunogenicity to a first mRNA- or vector-based SARS-CoV-2-vaccination dose in dialysis patients.\n\nIn a multicenter observational pilot study, 2 weeks after a first vaccination (BNT162b2/Pfizer-BioNTech [Comirnaty] or ChAdOx1 nCoV-19/Oxford-Astra-Zeneca [Vaxzevria]), hemodialysis patients (N = 23), peritoneal dialysis patients (N = 4) and healthy staff (N = 14) were tested for SARS-CoV-2-spike IgG/IgM, Nucleocapsid-protein-IgG-antibodies and plasma ACE2-receptor-binding-inhibition capacity. Hemodialysis patients who had had prior COVID-19 infection (N = 18) served as controls. Both response to first SARS-CoV-2 vaccination and IgG spike-positivity following prior COVID-19 infection were defined as SARS-CoV-2 spike IgG levels \u2265 50 AU/mL.\n\nVaccination responder rates were 17.4% (4/23) in hemodialysis patients, 100% (4/4) in peritoneal dialysis patients and 57.1% (8/14) in staff (HD vs. PD: p = 0.004, HD vs. staff: p = 0.027). Among hemodialysis patients, type of vaccine (Comirnaty N = 11, Vaxzevria N = 12, 2 responders each) did not appear to influence antibody levels (IgG spike: Comirnaty median 0.0 [1.-3. quartile 0.0-3.8] versus Vaxzevria 4.3 [1.6-20.1] AU/mL, p = 0.079). Of responders to the first dose of SARS-CoV-2 vaccination among hemodialysis patients (N = 4/23), median IgG spike levels and ACE2-receptor-binding-inhibition capacity were lower than that of IgG spike-positive hemodialysis patients with prior COVID-19 infection (13/18, 72.2%): IgG spike: median 222.0, 1.-3. quartile 104.1-721.9 versus median 3794.6, 1.-3. quartile 793.4-9357.9 AU/mL, p = 0.015; ACE2-receptor-binding-inhibition capacity: median 11.5%, 1.-3. quartile 5.0-27.3 versus median 74.8%, 1.-3. quartile 44.9-98.1, p = 0.002.\n\nTwo weeks after their first mRNA- or vector-based SARS-CoV-2 vaccination, hemodialysis patients demonstrated lower antibody-related response than peritoneal dialysis patients and healthy staff or unvaccinated hemodialysis patients following prior COVID-19 infection.", "doi": "10.1007/s40620-021-01076-0", "pmid": "34050904", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40620-021-01076-0"}, {"db": "pmc", "key": "PMC8164063"}], "notes": [], "created": "2021-06-04T11:36:25.252Z", "modified": "2021-06-04T11:36:25.255Z"}, {"entity": "publication", "iuid": "2a3f46daaab347e1ae1cf81f945c32df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2a3f46daaab347e1ae1cf81f945c32df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2a3f46daaab347e1ae1cf81f945c32df"}}, "title": "High-throughput immunoassays for SARS-CoV-2 - considerable differences in performance when comparing three methods.", "authors": [{"family": "Ekelund", "given": "Oskar", "initials": "O"}, {"family": "Ekblom", "given": "Kim", "initials": "K"}, {"family": "Somajo", "given": "Sofia", "initials": "S"}, {"family": "Pattison-Granberg", "given": "Johanna", "initials": "J"}, {"family": "Olsson", "given": "Karl", "initials": "K"}, {"family": "Petersson", "given": "Annika", "initials": "A"}], "type": "journal article", "published": "2021-05-29", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "volume": null, "issue": null, "pages": "1-6", "issn-l": "2374-4235"}, "abstract": "The recently launched high-throughput assays for detecting antibodies against SARS-CoV-2 has contributed to the managing strategies for the COVID-19 pandemic. This study aimed to investigate the performance of three high-throughput assays and one rapid lateral flow test relative to regulatory authorities' recommended criteria.\n\nA total of 315 samples, including 150 pre-pandemic samples, 152 samples from SARS-CoV-2 RT-PCR positive individuals and 13 potentially cross-reactive samples were analysed with SARS-CoV-2 IgG (Abbott, Abbott Park, IL), Elecsys Anti-SARS-CoV-2 (Roche, Solna, Sweden), LIAISON SARS-CoV-2 S1/S2 IgG (DiaSorin, Saluggia, Italy) and 2019-nCOV IgG/IgM Rapid Test (Dynamiker Biotechnology Co., Tianjin, China).\n\nAll assays performed with a high level of specificity ranging from 96.7% to 99.3%. Sensitivity differed more between the assays, Roche exhibiting the highest sensitivity of 98.7%. The corresponding figures for Abbott, DiaSorin and Dynamiker Biotechnology were 80.9%, 89.0% and 72.4%, respectively.\n\nThe results of the evaluated SARS-CoV-2 assays vary considerably, as well as their ability to fulfil the performance criteria proposed by regulatory authorities. Introduction into clinical use in low-prevalent settings, should, therefore, be made with caution.", "doi": "10.1080/23744235.2021.1931434", "pmid": "34053400", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Proteins": null}, "xrefs": [], "notes": [], "created": "2021-06-04T11:30:48.052Z", "modified": "2021-06-04T11:30:48.055Z"}, {"entity": "publication", "iuid": "d1b37ba4b2974fd7a47738328a38bcc7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1b37ba4b2974fd7a47738328a38bcc7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1b37ba4b2974fd7a47738328a38bcc7"}}, "title": "Dysregulation of COVID-19 related gene expression in the COPD lung.", "authors": [{"family": "Watson", "given": "Alastair", "initials": "A"}, {"family": "\u00d6berg", "given": "Lisa", "initials": "L"}, {"family": "Angermann", "given": "Bastian", "initials": "B"}, {"family": "Spalluto", "given": "C Mirella", "initials": "CM"}, {"family": "H\u00fchn", "given": "Michael", "initials": "M"}, {"family": "Burke", "given": "Hannah", "initials": "H"}, {"family": "Cellura", "given": "Doriana", "initials": "D"}, {"family": "Freeman", "given": "Anna", "initials": "A"}, {"family": "Muthas", "given": "Daniel", "initials": "D"}, {"family": "Etal", "given": "Damla", "initials": "D"}, {"family": "Belfield", "given": "Graham", "initials": "G"}, {"family": "Karlsson", "given": "Fredrik", "initials": "F"}, {"family": "Nordstr\u00f6m", "given": "Karl", "initials": "K"}, {"family": "Ostridge", "given": "Kris", "initials": "K"}, {"family": "Staples", "given": "Karl J", "initials": "KJ"}, {"family": "Wilkinson", "given": "Tom", "initials": "T"}, {"family": "MICA II Studygroup", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-29", "journal": {"title": "Respir Res", "issn": "1465-993X", "volume": "22", "issue": "1", "pages": "164", "issn-l": "1465-9921"}, "abstract": "Chronic obstructive pulmonary disease (COPD) patients are at increased risk of poor outcome from Coronavirus disease (COVID-19). Early data suggest elevated Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) receptor angiotensin converting enzyme 2 (ACE2) expression, but relationships to disease phenotype and downstream regulators of inflammation in the Renin-Angiotensin system (RAS) are unknown. We aimed to determine the relationship between RAS gene expression relevant to SARS-CoV-2 infection in the lung with disease characteristics in COPD, and the regulation of newly identified SARS-CoV-2 receptors and spike-cleaving proteases, important for SARS-CoV-2 infection.\n\nWe quantified gene expression using RNA sequencing of epithelial brushings and bronchial biopsies from 31 COPD and 37 control subjects.\n\nACE2 gene expression (log2-fold change (FC)) was increased in COPD compared to ex-smoking (HV-ES) controls in epithelial brushings (0.25, p = 0.042) and bronchial biopsies (0.23, p = 0.050), and correlated with worse lung function (r = - 0.28, p = 0.0090). ACE2 was further increased in frequent exacerbators compared to infrequent exacerbators (0.51, p = 0.00045) and associated with use of ACE inhibitors (ACEi) (0.50, p = 0.0034), having cardiovascular disease (0.23, p = 0.048) or hypertension (0.34, p = 0.0089), and inhaled corticosteroid use in COPD subjects in bronchial biopsies (0.33, p = 0.049). Angiotensin II receptor type (AGTR)1 and 2 expression was decreased in COPD bronchial biopsies compared to HV-ES controls with log2FC of -0.26 (p = 0.033) and - 0.40, (p = 0.0010), respectively. However, the AGTR1:2 ratio was increased in COPD subjects compared with HV-ES controls, log2FC of 0.57 (p = 0.0051). Basigin, a newly identified potential SARS-CoV-2 receptor was also upregulated in both brushes, log2FC of 0.17 (p = 0.0040), and bronchial biopsies, (log2FC of 0.18 (p = 0.017), in COPD vs HV-ES. Transmembrane protease, serine (TMPRSS)2 was not differentially regulated between control and COPD. However, various other spike-cleaving proteases were, including TMPRSS4 and Cathepsin B, in both epithelial brushes (log2FC of 0.25 (p = 0.0012) and log2FC of 0.56 (p = 5.49E-06), respectively) and bronchial biopsies (log2FC of 0.49 (p = 0.00021) and log2FC of 0.246 (p = 0.028), respectively).\n\nThis study identifies key differences in expression of genes related to susceptibility and aetiology of COVID-19 within the COPD lung. Further studies to understand the impact on clinical course of disease are now required.", "doi": "10.1186/s12931-021-01755-3", "pmid": "34051791", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12931-021-01755-3"}], "notes": [], "created": "2021-06-04T11:33:58.818Z", "modified": "2021-06-04T11:35:52.210Z"}, {"entity": "publication", "iuid": "da0a1e3edde34e98982fa9faf6c59de4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/da0a1e3edde34e98982fa9faf6c59de4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/da0a1e3edde34e98982fa9faf6c59de4"}}, "title": "What drives transmission of severe acute respiratory syndrome coronavirus 2?", "authors": [{"family": "Andersson", "given": "Jan", "initials": "J"}], "type": "editorial", "published": "2021-05-28", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": null, "issue": null, "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic represents the most severe public health crisis of the last 100 years both in terms of societal impact and illness. As of May 10 th more than 155 million individuals have contracted COVID-19 and more than 3,3 million have died from the disease. Even though the underlying pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a member of the coronavirus family that has been studied extensively for many decades, the world was ill-prepared to deal with its high degree of contagion combined with its broad spectrum of virulence. Regretfully, knowledge gained about the physical underpinnings of respiratory viral transmission after the 1918 Spanish flu pandemic was largely ignored by the public health community at the outset of the COVID-19 pandemic.", "doi": "10.1111/joim.13335", "pmid": "34048113", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-29T16:28:03.282Z", "modified": "2021-05-29T16:28:03.294Z"}, {"entity": "publication", "iuid": "6908fbc9bddc495a9c868ac16f0fbc33", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6908fbc9bddc495a9c868ac16f0fbc33.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6908fbc9bddc495a9c868ac16f0fbc33"}}, "title": "Prevalence and Predictors of Loneliness Among Youth During the Time of COVID-19: A Multinational Study.", "authors": [{"family": "Al Omari", "given": "Omar", "initials": "O"}, {"family": "Al Sabei", "given": "Sulaiman", "initials": "S"}, {"family": "Al Rawajfah", "given": "Omar", "initials": "O"}, {"family": "Abu Sharour", "given": "Loai", "initials": "L"}, {"family": "Al-Hashmi", "given": "Iman", "initials": "I"}, {"family": "Al Qadire", "given": "Mohammad", "initials": "M"}, {"family": "Khalaf", "given": "Atika", "initials": "A"}], "type": "journal article", "published": "2021-05-28", "journal": {"title": "J Am Psychiatr Nurses Assoc", "issn": "1532-5725", "volume": null, "issue": null, "pages": "10783903211017640", "issn-l": null}, "abstract": "Given the restrictions associated with COVID-19, feelings of loneliness among youth may increase.\n\nThe aims of the current study were to assess the prevalence of loneliness among young people at the time of COVID-19 and to identify whether selected variables related to the pandemic predicted the level of loneliness.\n\nA cross-sectional study using WhatsApp and Facebook social media platforms was conducted to survey 1,057 young people aged 15 to 24 years from six Middle Eastern countries. Participants completed survey items including demographic and COVID-19-related questions; the Depression, Anxiety and Stress Scale (DASS); the Satisfaction With Life Scale (SWLS); and the UCLA Loneliness Scale.\n\nThe prevalence of experienced loneliness was 1 (0.1%), 625 (59.1%), 429 (40.6%), and 2 (0.2%), reflecting low, moderate, moderately high, and high experiences for loneliness, respectively. History of depression or anxiety, being dissatisfied with life, and having depression at the time of COVID-19 were significant predictors of loneliness among youth. The model was significant ( F = 44.95, p < .05) and accounted for 29.8% of the variance in UCLA Loneliness Scale scores.\n\nWe found that the high prevalence rate of loneliness during the COVID-19 pandemic was correlated with depression and impaired life satisfaction among Middle Eastern youth. Thus, special attention and interventional action plans need to be developed taking into consideration the youths' special situation during COVID-19.", "doi": "10.1177/10783903211017640", "pmid": "34047225", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-29T15:22:40.898Z", "modified": "2021-05-29T15:22:40.921Z"}, {"entity": "publication", "iuid": "49d31b83abc549c9b2c040fa0690d771", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49d31b83abc549c9b2c040fa0690d771.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49d31b83abc549c9b2c040fa0690d771"}}, "title": "Letter to the editor regarding the Topical Review \"Silent hypoxaemia in COVID-19 patients\" by Simonson et al. 2021.", "authors": [{"family": "Mulder", "given": "Eric", "initials": "E"}, {"family": "Pernett", "given": "Frank", "initials": "F"}, {"family": "Schagatay", "given": "Erika", "initials": "E"}], "type": "letter", "published": "2021-05-28", "journal": {"title": "J Physiol", "issn": "1469-7793", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1113/JP281882", "pmid": "34047369", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-29T15:21:48.640Z", "modified": "2021-05-29T15:21:48.656Z"}, {"entity": "publication", "iuid": "4bddd32590714a84adae0eb53060c511", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4bddd32590714a84adae0eb53060c511.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4bddd32590714a84adae0eb53060c511"}}, "title": "Incidence and Severity of Covid-19 in Patients with and without Previously Verified Infections with Common Cold Coronaviruses.", "authors": [{"family": "Ringlander", "given": "Johan", "initials": "J", "orcid": "0000-0002-8483-6504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64f85af7dceb436498422e62f1a98c89.json"}}, {"family": "Martner", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Westin", "given": "Johan", "initials": "J"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K"}], "type": "letter", "published": "2021-05-28", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899", "volume": "223", "issue": "10", "pages": "1831-1832"}, "abstract": null, "doi": "10.1093/infdis/jiab089", "pmid": "33780548", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6199850"}, {"db": "pmc", "key": "PMC8083637"}], "notes": [], "created": "2021-03-31T08:12:57.627Z", "modified": "2021-06-14T14:21:11.954Z"}, {"entity": "publication", "iuid": "95af6fdd90c945bb8a6026c4fd1d2092", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95af6fdd90c945bb8a6026c4fd1d2092.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95af6fdd90c945bb8a6026c4fd1d2092"}}, "title": "Associations of baseline use of biologic or targeted synthetic DMARDs with COVID-19 severity in rheumatoid arthritis: Results from the COVID-19 Global Rheumatology Alliance physician registry.", "authors": [{"family": "Sparks", "given": "Jeffrey A", "initials": "JA"}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Seet", "given": "Andrea M", "initials": "AM"}, {"family": "Gianfrancesco", "given": "Milena A", "initials": "MA"}, {"family": "Izadi", "given": "Zara", "initials": "Z"}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL"}, {"family": "Strangfeld", "given": "Anja", "initials": "A"}, {"family": "Gossec", "given": "Laure", "initials": "L"}, {"family": "Carmona", "given": "Loreto", "initials": "L"}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S"}, {"family": "Trupin", "given": "Laura", "initials": "L"}, {"family": "Rush", "given": "Stephanie", "initials": "S"}, {"family": "Katz", "given": "Patricia", "initials": "P"}, {"family": "Schmajuk", "given": "Gabriela", "initials": "G"}, {"family": "Jacobsohn", "given": "Lindsay", "initials": "L"}, {"family": "Wise", "given": "Leanna", "initials": "L"}, {"family": "Gilbert", "given": "Emily L", "initials": "EL"}, {"family": "Duarte-Garc\u00eda", "given": "Ali", "initials": "A"}, {"family": "Valenzuela-Almada", "given": "Maria O", "initials": "MO"}, {"family": "Pons-Estel", "given": "Guillermo J", "initials": "GJ"}, {"family": "Isnardi", "given": "Carolina A", "initials": "CA"}, {"family": "Berbotto", "given": "Guillermo A", "initials": "GA"}, {"family": "Hsu", "given": "Tiffany Y-T", "initials": "TY"}, {"family": "D'Silva", "given": "Kristin M", "initials": "KM"}, {"family": "Patel", "given": "Naomi J", "initials": "NJ"}, {"family": "Kearsley-Fleet", "given": "Lianne", "initials": "L"}, {"family": "Sch\u00e4fer", "given": "Martin", "initials": "M"}, {"family": "Ribeiro", "given": "Sandra L\u00facia Euz\u00e9bio", "initials": "SLE"}, {"family": "Al Emadi", "given": "Samar", "initials": "S"}, {"family": "Tidblad", "given": "Liselotte", "initials": "L"}, {"family": "Scir\u00e8", "given": "Carlo Alberto", "initials": "CA"}, {"family": "Raffeiner", "given": "Bernd", "initials": "B"}, {"family": "Thomas", "given": "Thierry", "initials": "T"}, {"family": "Flipo", "given": "Ren\u00e9-Marc", "initials": "RM"}, {"family": "Avouac", "given": "J\u00e9r\u00f4me", "initials": "J"}, {"family": "Seror", "given": "Rapha\u00e8le", "initials": "R"}, {"family": "Bernardes", "given": "Miguel", "initials": "M"}, {"family": "Cunha", "given": "Maria Margarida", "initials": "MM"}, {"family": "Hasseli", "given": "Rebecca", "initials": "R"}, {"family": "Schulze-Koops", "given": "Hendrik", "initials": "H"}, {"family": "M\u00fcller-Ladner", "given": "Ulf", "initials": "U"}, {"family": "Specker", "given": "Christof", "initials": "C"}, {"family": "Souza", "given": "Viviane Angelina de", "initials": "VA"}, {"family": "Mota", "given": "Licia Maria Henrique da", "initials": "LMHD"}, {"family": "Gomides", "given": "Ana Paula Monteiro", "initials": "APM"}, {"family": "Dieud\u00e9", "given": "Philippe", "initials": "P"}, {"family": "Nikiphorou", "given": "Elena", "initials": "E"}, {"family": "Kronzer", "given": "Vanessa L", "initials": "VL"}, {"family": "Singh", "given": "Namrata", "initials": "N"}, {"family": "Ugarte-Gil", "given": "Manuel F", "initials": "MF"}, {"family": "Wallace", "given": "Beth", "initials": "B"}, {"family": "Akpabio", "given": "Akpabio", "initials": "A"}, {"family": "Thomas", "given": "Ranjeny", "initials": "R"}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Costello", "given": "Wendy", "initials": "W"}, {"family": "Grainger", "given": "Rebecca", "initials": "R"}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS"}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Sufka", "given": "Paul", "initials": "P"}, {"family": "Robinson", "given": "Philip C", "initials": "PC"}, {"family": "Machado", "given": "Pedro M", "initials": "PM"}, {"family": "Yazdany", "given": "Jinoos", "initials": "J"}, {"family": "COVID-19 Global Rheumatology Alliance", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-28", "journal": {"title": "Ann Rheum Dis", "issn": "1468-2060", "volume": null, "issue": null, "issn-l": null}, "abstract": "To investigate baseline use of biologic or targeted synthetic (b/ts) disease-modifying antirheumatic drugs (DMARDs) and COVID-19 outcomes in rheumatoid arthritis (RA).\n\nWe analysed the COVID-19 Global Rheumatology Alliance physician registry (from 24 March 2020 to 12 April 2021). We investigated b/tsDMARD use for RA at the clinical onset of COVID-19 (baseline): abatacept (ABA), rituximab (RTX), Janus kinase inhibitors (JAKi), interleukin 6 inhibitors (IL-6i) or tumour necrosis factor inhibitors (TNFi, reference group). The ordinal COVID-19 severity outcome was (1) no hospitalisation, (2) hospitalisation without oxygen, (3) hospitalisation with oxygen/ventilation or (4) death. We used ordinal logistic regression to estimate the OR (odds of being one level higher on the ordinal outcome) for each drug class compared with TNFi, adjusting for potential baseline confounders.\n\nOf 2869 people with RA (mean age 56.7 years, 80.8% female) on b/tsDMARD at the onset of COVID-19, there were 237 on ABA, 364 on RTX, 317 on IL-6i, 563 on JAKi and 1388 on TNFi. Overall, 613 (21%) were hospitalised and 157 (5.5%) died. RTX (OR 4.15, 95% CI 3.16 to 5.44) and JAKi (OR 2.06, 95% CI 1.60 to 2.65) were each associated with worse COVID-19 severity compared with TNFi. There were no associations between ABA or IL6i and COVID-19 severity.\n\nPeople with RA treated with RTX or JAKi had worse COVID-19 severity than those on TNFi. The strong association of RTX and JAKi use with poor COVID-19 outcomes highlights prioritisation of risk mitigation strategies for these people.", "doi": "10.1136/annrheumdis-2021-220418", "pmid": "34049860", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "annrheumdis-2021-220418"}], "notes": [], "created": "2021-06-04T11:39:56.896Z", "modified": "2021-06-04T11:39:56.913Z"}, {"entity": "publication", "iuid": "20a58e6949654e17abb103cef04c1ee9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/20a58e6949654e17abb103cef04c1ee9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/20a58e6949654e17abb103cef04c1ee9"}}, "title": "Acuity level of care as a predictor of case fatality and prolonged hospital stay in patients with COVID-19: a hospital-based observational follow-up study from Pakistan.", "authors": [{"family": "Almas", "given": "Aysha", "initials": "A"}, {"family": "Mushtaq", "given": "Zain", "initials": "Z"}, {"family": "Moller", "given": "Jette", "initials": "J"}], "type": "journal article", "published": "2021-05-28", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "5", "pages": "e045414"}, "abstract": "To determine if there is an association between acuity level of care (ALC), case fatality and length of stay in patients admitted to hospital due to COVID-19.\r\n\r\nA hospital-based observational follow-up study.\r\n\r\nInternal Medicine Service of the Aga Khan University Hospital, Pakistan, from 26 February 2020 to 30 June 2020.\r\n\r\nAdult patients with confirmed COVID-19, aged \u226518 years.\r\n\r\nALC was categorised into low, intermediate and high level and patients were triaged using the standard emergency severity illness score. All patients were followed until the end of hospital admission for the outcome of case fatality and length of stay.\r\n\r\nA total of 822 patients with COVID-19 were admitted during the study period and 699 met inclusion criteria. The mean age was 54.5 years and 67% were males; 50.4% were triaged to low, 42.5% to intermediate and 7.2% to high acuity care. The overall case-fatality rate was 11.6%, with the highest (52%) in high acuity level followed by 16.2% in intermediate and 2% in low acuity care. Acuity level was associated with case fatality, with an HR (95% CI) of 5.0 (2.0 to 12.1) for high versus low acuity care and an HR of 2.7 (1.2, 6.4) for intermediate versus low acuity care, after adjusting for age, sex and common comorbidities including diabetes, hypertension, ischaemic heart disease and chronic lung disease. Similarly, acuity level was also associated with length of hospital stay.\r\n\r\nHigh and intermediate acuity level is associated with higher case fatality rate and prolonged length of hospital stay in patients admitted with COVID-19. In resource-limited settings where the provision of high acuity care is limited, the intermediate care acuity could serve as a useful strategy to treat relatively less critical patients with COVID-19.", "doi": "10.1136/bmjopen-2020-045414", "pmid": "34049912", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-045414"}], "notes": [], "created": "2021-06-04T11:39:03.792Z", "modified": "2021-07-14T09:07:44.390Z"}, {"entity": "publication", "iuid": "428c57c97b5143e58cc7f7f5d705cb70", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/428c57c97b5143e58cc7f7f5d705cb70.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/428c57c97b5143e58cc7f7f5d705cb70"}}, "title": "Mortality in adult patients with solid or hematological malignancies and SARS-CoV-2 infection with a specific focus on lung and breast malignancies: a systematic review and meta-analysis.", "authors": [{"family": "Tagliamento", "given": "Marco", "initials": "M"}, {"family": "Agostinetto", "given": "Elisa", "initials": "E"}, {"family": "Bruzzone", "given": "Marco", "initials": "M"}, {"family": "Ceppi", "given": "Marcello", "initials": "M"}, {"family": "Saini", "given": "Kamal S", "initials": "KS"}, {"family": "de Azambuja", "given": "Evandro", "initials": "E"}, {"family": "Punie", "given": "Kevin", "initials": "K"}, {"family": "Westphalen", "given": "C Benedikt", "initials": "CB"}, {"family": "Morgan", "given": "Gilberto", "initials": "G"}, {"family": "Pronzato", "given": "Paolo", "initials": "P"}, {"family": "Del Mastro", "given": "Lucia", "initials": "L"}, {"family": "Poggio", "given": "Francesca", "initials": "F"}, {"family": "Lambertini", "given": "Matteo", "initials": "M"}], "type": "journal article", "published": "2021-05-27", "journal": {"title": "Crit Rev Oncol Hematol", "issn": "1879-0461", "volume": null, "issue": null, "pages": "103365", "issn-l": null}, "abstract": "A systematic review and meta-analysis were performed to estimate the mortality in patients with cancer and SARS-CoV-2 infection.\n\nA systematic search of PubMed, up to 31 January 2021, identified publications reporting the case-fatality rate (CFR) among adult patients with solid and/or hematological malignancies and SARS-CoV-2 infection. The CFR, defined as the rate of death among this population, was assessed with a random effect model; 95% confidence intervals (CI) were calculated.\n\nAmong 135 selected studies (N = 33,879 patients), the CFR was 25.4% (95% CI 22.9%-28.2%). At a sensitivity analysis of studies with at least 100 patients, the CFR was 21.9% (95% CI 19.1%-25.1%). Among COVID-19 patients with lung (N = 1,135) and breast (N = 1,296) cancers, CFR were 32.4% (95% CI 26.5%-39.6%) and 14.2% (95% CI 9.3%-21.8%), respectively.\n\nCOVID-19 patients with lung cancer have a comparatively higher probability of mortality than those with breast cancer.", "doi": "10.1016/j.critrevonc.2021.103365", "pmid": "34052423", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1040-8428(21)00153-0"}], "notes": [], "created": "2021-05-31T16:10:57.629Z", "modified": "2021-06-04T11:33:13.590Z"}, {"entity": "publication", "iuid": "937f550349b9447aa382b9d0ae959148", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/937f550349b9447aa382b9d0ae959148.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/937f550349b9447aa382b9d0ae959148"}}, "title": "Iatrogenic immunosuppression can lead to prolonged viral shedding and absent immune response to COVID-19.", "authors": [{"family": "Psaros Einberg", "given": "A", "initials": "A"}, {"family": "Casswall", "given": "T", "initials": "T"}, {"family": "Arnell", "given": "H", "initials": "H"}, {"family": "Nowak", "given": "G", "initials": "G"}, {"family": "Mirazimi", "given": "A", "initials": "A"}, {"family": "Sundin", "given": "M", "initials": "M"}, {"family": "Fischler", "given": "B", "initials": "B"}], "type": "journal article", "published": "2021-05-27", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": null, "issue": null, "issn-l": "0803-5253"}, "abstract": "In the era of the COVID-19 pandemic, paediatricians need to remember that immunocompromised children might experience prolonged viral shedding and impaired immunological response to SARS-CoV-2. We report a girl diagnosed with an unresectable angiosarcoma of the liver who underwent liver transplantation in June 2019. The basic immunosuppression protocol consisted of tacrolimus and prednisolone. Additionally, she was on adjuvant treatment with trametinib, a mitogen-activated protein kinase (MEK) inhibitor.", "doi": "10.1111/apa.15955", "pmid": "34043855", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-29T15:27:50.514Z", "modified": "2021-05-29T15:28:08.933Z"}, {"entity": "publication", "iuid": "c1a5506828024e04a38f14fd2e79843d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1a5506828024e04a38f14fd2e79843d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1a5506828024e04a38f14fd2e79843d"}}, "title": "Fostering local involvement for biodiversity conservation in tropical regions: Lessons from Madagascar during the COVID-19 pandemic.", "authors": [{"family": "Razanatsoa", "given": "Estelle", "initials": "E", "orcid": "0000-0002-7219-1411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/454a8b9297fc49e28b40309d49f0f20a.json"}}, {"family": "Andriantsaralaza", "given": "Seheno", "initials": "S", "orcid": "0000-0002-6098-2056", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22ed6f4d679f4b7586604bdeaab878b1.json"}}, {"family": "Holmes", "given": "Sheila M", "initials": "SM", "orcid": "0000-0002-6420-5510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b17dfb2bb1174ca7a174d8f163e137f4.json"}}, {"family": "Rakotonarivo", "given": "O Sarobidy", "initials": "OS", "orcid": "0000-0002-8032-1431", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/836e1a64ab9a406d815ac9eae8407e30.json"}}, {"family": "Ratsifandrihamanana", "given": "Anitry N", "initials": "AN"}, {"family": "Randriamiharisoa", "given": "Lalatiana", "initials": "L"}, {"family": "Ravaloharimanitra", "given": "Maholy", "initials": "M"}, {"family": "Ramahefamanana", "given": "Narindra", "initials": "N"}, {"family": "Tahirinirainy", "given": "Dinasoa", "initials": "D"}, {"family": "Raharimampionona", "given": "Jeannie", "initials": "J"}], "type": "journal article", "published": "2021-05-27", "journal": {"title": "Biotropica", "issn": "0006-3606", "issn-l": null}, "abstract": "Tropical ecosystems host a large proportion of global biodiversity and directly support the livelihoods of many of the world's poorest, and often marginalized, people through ecosystem goods and services and conservation employment. The coronavirus pandemic has challenged existing conservation structures and management but provides an opportunity to re-examine strategies and research approaches across the tropics to build resilience for future crises. Based on the personal experiences of conservation leaders, managers, and researchers from Madagascar during this period, we discuss the coping strategies of multiple biodiversity conservation organizations during the coronavirus pandemic. We highlight the vital role of local communities in building and maintaining resilient conservation practices that are robust to global disruptions such as the COVID-19 crisis. We argue that the integration of local experts and communities in conservation, research, and financial decision-making is essential to a strong foundation for biodiversity conservation in developing countries to stand up to future environmental, political, and health crises. This integration could be achieved through the support of training and capacity building of local researchers and community members and these actions would also enhance the development of strong, equitable long-term collaborations with international communities. Equipped with such capacity, conservationists and researchers from these regions could establish long-term biodiversity conservation strategies that are adapted to local context, and communities could flexibly balance biodiversity and livelihood needs as circumstances change, including weathering the isolation and financial challenges of local or global crises.", "doi": "10.1111/btp.12967", "pmid": "34219750", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "BTP12967"}, {"db": "pmc", "key": "PMC8239783"}], "notes": [], "created": "2021-08-06T08:53:44.583Z", "modified": "2021-08-06T08:53:59.254Z"}, {"entity": "publication", "iuid": "8767c26e5c524de09e1225c60e4f29eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8767c26e5c524de09e1225c60e4f29eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8767c26e5c524de09e1225c60e4f29eb"}}, "title": "Vaccine Inequities, Intellectual Property Rights and Pathologies of Power in the Global Response to COVID-19", "authors": [{"family": "Engebretsen", "given": "Eivind", "initials": "E", "orcid": "0000-0001-9455-110X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fce6bb59db844a65b3c378ae1e97d867.json"}}, {"family": "Ottersen", "given": "Ole Petter", "initials": "OP"}], "type": "journal-article", "published": "2021-05-26", "journal": {"title": "Int J Health Policy Manag", "issn": "2322-5939", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.34172/ijhpm.2021.57", "pmid": "34124871", "labels": {"Category: Social Science & Humanities": null, "Category: Other": null, "Type: Other": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-06-17T07:43:43.010Z", "modified": "2023-12-08T06:15:24.852Z"}, {"entity": "publication", "iuid": "1e4e8c46e7ca4527a361f0c9b526b8d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1e4e8c46e7ca4527a361f0c9b526b8d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1e4e8c46e7ca4527a361f0c9b526b8d0"}}, "title": "Risk of stress/depression and functional impairment in Denmark immediately following a COVID-19 shutdown.", "authors": [{"family": "Andersen", "given": "Lars H", "initials": "LH"}, {"family": "Fallesen", "given": "Peter", "initials": "P"}, {"family": "Bruckner", "given": "Tim A", "initials": "TA"}], "type": "journal article", "published": "2021-05-26", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "984"}, "abstract": "Existing estimates of the impact of the COVID-19 burden on mental wellbeing come from countries with high mortality rates. This study therefore aimed to investigate the impact of the first COVID-19 lockdown (March-April 2020) on risk for stress/depression and functional impairment in a representative sample of adult individuals in Denmark, which had lower infection rates, and whether the impact of lockdown was heterogeneous across living situation.\r\n\r\nUsing a representative, randomly drawn sample from the complete Danish adult population interviewed in March 2 to April 13, 2020 (n = 2836) and again in July 2020 (n = 1526, 54% retention rate), we study how the imposed lockdown announced March 11 following the onset of the first Danish wave of COVID-19 infections affected mental wellbeing. We use the World Health Organization Five Well-being Index (WHO-5) and the Work and Social Adjustment Scale (WSAS) to capture risk for stress/depression (WHO-5 < 50) and functional impairment (WSAS > 10). Using covariate adjusted ordinary least squares linear probability models and exploiting variation in the timing of responses occurring just before and just after the introduction of lockdown, we compare respondents before lockdown to respondents that answered during lockdown, as well as to answers in re-interviews in July.\r\n\r\nIn our fully controlled models, we find reduced depressive symptoms among adults immediately after the shutdown, concentrated in adults with children living at home (-.089, p < .01 (from pre lockdown baseline .273)). Measures of functional impairment also declined immediately after the March shutdown among adults with children living at home (-.066, p < .05 (from pre lockdown baseline .150)). Impairment intensified for the entire sample between March and July (+.199, p < .001 (from pre lockdown baseline .248)), but depressive symptoms remained at lower rate in July (-.033, p < .05 (from pre lockdown baseline .332).\r\n\r\nFindings in Denmark indicate that living with children at home may have, in the short term, buffered the potential mental health sequelae of the COVID-19 shutdown.", "doi": "10.1186/s12889-021-11020-3", "pmid": "34039323", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11020-3"}], "notes": [], "created": "2021-05-29T15:31:51.419Z", "modified": "2022-11-23T09:00:29.216Z"}, {"entity": "publication", "iuid": "c4684de637ff43ec912ca70bf831a82a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c4684de637ff43ec912ca70bf831a82a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c4684de637ff43ec912ca70bf831a82a"}}, "title": "Fostering global data sharing: highlighting the recommendations of the Research Data Alliance COVID-19 working group", "authors": [{"family": "Austin", "given": "Claire C", "initials": "CC", "orcid": "0000-0001-9138-5986", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c6b7cea2c224961825b7986b7d1f17f.json"}}, {"family": "Bernier", "given": "Alexander", "initials": "A", "orcid": "0000-0001-8615-8375", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93d210c6bb9047daa58cfe87dc53fe52.json"}}, {"family": "Bezuidenhout", "given": "Louise", "initials": "L", "orcid": "0000-0003-4328-3963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b9fce97de2e4f54b82b06d20695e735.json"}}, {"family": "Bicarregui", "given": "Juan", "initials": "J", "orcid": "0000-0001-5250-7653", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69a0641e17eb47058ac58941c180586b.json"}}, {"family": "Biro", "given": "Timea", "initials": "T", "orcid": "0000-0002-8900-8978", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e00a6f3933b485898c9524dd5f9dc3a.json"}}, {"family": "Cambon-Thomsen", "given": "Anne", "initials": "A", "orcid": "0000-0001-8793-3644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96673088e61d4699a4197088c6eba954.json"}}, {"family": "Carroll", "given": "Stephanie Russo", "initials": "SR", "orcid": "0000-0002-8996-8071", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bbcfdde655a4415f8a1198811932af90.json"}}, {"family": "Cournia", "given": "Zoe", "initials": "Z", "orcid": "0000-0001-9287-364X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8a80098a1fa4268b4b7321618482e8b.json"}}, {"family": "Dabrowski", "given": "Piotr Wojciech", "initials": "PW", "orcid": "0000-0003-4893-805X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c7b5d2b1ed846538c5d183782864a3c.json"}}, {"family": "Diallo", "given": "Gayo", "initials": "G"}, {"family": "Duflot", "given": "Thomas", "initials": "T", "orcid": "0000-0002-8730-284X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c0158acd3a34521a3fbd36f0ef1d823.json"}}, {"family": "Garcia", "given": "Leyla", "initials": "L", "orcid": "0000-0003-3986-0510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0e247431cfc446599995c672f5d89bc.json"}}, {"family": "Gesing", "given": "Sandra", "initials": "S"}, {"family": "Gonzalez-Beltran", "given": "Alejandra", "initials": "A", "orcid": "0000-0003-3499-8262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12ad5713a3324f83915b8136aa7e43b5.json"}}, {"family": "Gururaj", "given": "Anupama", "initials": "A", "orcid": "0000-0002-4221-4379", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab358e34447c439d90a0cbcf488ccd4f.json"}}, {"family": "Harrower", "given": "Natalie", "initials": "N", "orcid": "0000-0002-7487-4881", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/466ab83cba30459dbe96c178cc371f50.json"}}, {"family": "Lin", "given": "Dawei", "initials": "D"}, {"family": "Medeiros", "given": "Claudia", "initials": "C", "orcid": "0000-0003-1908-4753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f57ea5f61e384f458245e5f83e5124ac.json"}}, {"family": "M\u00e9ndez", "given": "Eva", "initials": "E", "orcid": "0000-0002-5337-4722", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e2ac979f16f44beb29275697c0bba62.json"}}, {"family": "Meyers", "given": "Natalie", "initials": "N", "orcid": "0000-0001-6441-6716", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3261010fd1d5419aab0011cf7347b86d.json"}}, {"family": "Mietchen", "given": "Daniel", "initials": "D", "orcid": "0000-0001-9488-1870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5c738bfdab3d4c53a35b92ded513d72d.json"}}, {"family": "Nagrani", "given": "Rajini", "initials": "R", "orcid": "0000-0002-1708-2319", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef6c842faa8743c5912026afa0d8ebde.json"}}, {"family": "Nilsonne", "given": "Gustav", "initials": "G", "orcid": "0000-0001-5273-0150", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6211be5fc4ce4a63bddae08e6d336f15.json"}}, {"family": "Parker", "given": "Simon", "initials": "S"}, {"family": "Pickering", "given": "Brian", "initials": "B", "orcid": "0000-0002-6815-2938", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ca8df52b7cba413ebab9e6ca55c7d0e2.json"}}, {"family": "Pienta", "given": "Amy", "initials": "A"}, {"family": "Polydoratou", "given": "Panayiota", "initials": "P", "orcid": "0000-0002-7551-8002", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c6bf54582da40eb880813105e82f96b.json"}}, {"family": "Psomopoulos", "given": "Fotis", "initials": "F", "orcid": "0000-0002-0222-4273", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24743c9924274f449cbebde9c84ccebe.json"}}, {"family": "Rennes", "given": "Stephanie", "initials": "S", "orcid": "0000-0003-1458-7773", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e9c29b5851d4825b59c8c63ac241cbf.json"}}, {"family": "Rowe", "given": "Robyn", "initials": "R", "orcid": "0000-0003-0591-6213", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2cf7aefe4a5c4ceebc2290f40bc0c52f.json"}}, {"family": "Sansone", "given": "Susanna Assunta", "initials": "SA", "orcid": "0000-0001-5306-5690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3989d62ae34542fdbf5840a81957d964.json"}}, {"family": "Shanahan", "given": "Hugh", "initials": "H", "orcid": "0000-0003-1374-6015", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bab1d81eff584e68aaa469009875060c.json"}}, {"family": "Sitz", "given": "Lina", "initials": "L", "orcid": "0000-0002-6333-4986", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8beab9cc751647a6bb33e1ac5764eff8.json"}}, {"family": "Stocks", "given": "Joanne", "initials": "J", "orcid": "0000-0002-7800-6002", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8a546486dd840038ccd2c6f788f0ab9.json"}}, {"family": "Tovani-Palone", "given": "Marcos Roberto", "initials": "MR"}, {"family": "Uhlmansiek", "given": "Mary", "initials": "M", "orcid": "0000-0002-7949-2057", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9cc1455ca3f84309aac4f635c863b1ff.json"}}, {"family": null, "given": "", "initials": ""}], "type": "journal-article", "published": "2021-05-26", "journal": {"title": "Wellcome Open Res", "issn": "2398-502X", "volume": "5", "pages": "267", "issn-l": null}, "abstract": "The systemic challenges of the COVID-19 pandemic require cross-disciplinary collaboration in a global and timely fashion. Such collaboration needs open research practices and the sharing of research outputs, such as data and code, thereby facilitating research and research reproducibility and timely collaboration beyond borders. The Research Data Alliance COVID-19 Working Group recently published a set of recommendations and guidelines on data sharing and related best practices for COVID-19 research. These guidelines include recommendations for clinicians, researchers, policy- and decision-makers, funders, publishers, public health experts, disaster preparedness and response experts, infrastructure providers from the perspective of different domains (Clinical Medicine, Omics, Epidemiology, Social Sciences, Community Participation, Indigenous Peoples, Research Software, Legal and Ethical Considerations), and other potential users. These guidelines include recommendations for researchers, policymakers, funders, publishers and infrastructure providers from the perspective of different domains (Clinical Medicine, Omics, Epidemiology, Social Sciences, Community Participation, Indigenous Peoples, Research Software, Legal and Ethical Considerations). Several overarching themes have emerged from this document such as the need to balance the creation of data adherent to FAIR principles (findable, accessible, interoperable and reusable), with the need for quick data release; the use of trustworthy research data repositories; the use of well-annotated data with meaningful metadata; and practices of documenting methods and software. The resulting document marks an unprecedented cross-disciplinary, cross-sectoral, and cross-jurisdictional effort authored by over 160 experts from around the globe. This letter summarises key points of the Recommendations and Guidelines, highlights the relevant findings, shines a spotlight on the process, and suggests how these developments can be leveraged by the wider scientific community.", "doi": "10.12688/wellcomeopenres.16378.2", "pmid": "33501381", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7808050.2"}], "notes": [], "created": "2021-06-11T05:08:48.036Z", "modified": "2021-06-11T05:10:26.069Z"}, {"entity": "publication", "iuid": "1ee3f6241f5342e398bfae010ed8574f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ee3f6241f5342e398bfae010ed8574f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ee3f6241f5342e398bfae010ed8574f"}}, "title": "Diagnostic Potential of a Luminex-Based Coronavirus Disease 2019 Suspension Immunoassay (COVID-19 SIA) for the Detection of Antibodies against SARS-CoV-2.", "authors": [{"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Kolstad", "given": "Linda", "initials": "L"}, {"family": "Lindahl", "given": "Johanna F", "initials": "JF"}, {"family": "Albinsson", "given": "Bo", "initials": "B"}, {"family": "Bergqvist", "given": "Anders", "initials": "A"}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "journal article", "published": "2021-05-26", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "13", "issue": "6", "pages": null}, "abstract": "Due to the current, rapidly increasing Coronavirus disease 2019 (COVID-19) pandemic, efficient and highly specific diagnostic methods are needed. The receptor-binding part of the spike (S) protein, S1, has been suggested to be highly virus-specific; it does not cross-react with antibodies against other coronaviruses. Three recombinant partial S proteins of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) expressed in mammalian or baculovirus-insect cells were evaluated as antigens in a Luminex-based suspension immunoassay (SIA). The best performing antigen (S1; amino acids 16-685) was selected and further evaluated by serum samples from 76 Swedish patients or convalescents with COVID-19 (previously PCR and/or serologically confirmed), 200 pre-COVID-19 individuals (180 blood donors and 20 infants), and 10 patients with acute Epstein-Barr virus infection. All 76 positive samples showed detectable antibodies to S1, while none of the 210 negative controls gave a false positive antibody reaction. We further compared the COVID-19 SIA with a commercially available enzyme immunoassay and a previously evaluated COVID-19 rapid antibody test. The results revealed an overall assay sensitivity of 100%, a specificity of 100% for both IgM and IgG, a quantitative ability at concentrations up to 25 BAU/mL, and a better performance as compared to the commercial assays, suggesting the COVID-19 SIA as a most valuable tool for efficient laboratory-based serology.", "doi": "10.3390/v13060993", "pmid": "34073484", "labels": {"Category: Other": null, "Type: Journal article": null, "Funder: H2020": null, "Funder: VR": null, "Category: Biochemistry": null, "Research Area: High-throughput and high-content serology": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "v13060993"}], "notes": [], "created": "2021-06-04T11:11:07.153Z", "modified": "2021-08-25T08:17:08.764Z"}, {"entity": "publication", "iuid": "9e8e9c1414cb4a1d8985ebb84f523153", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9e8e9c1414cb4a1d8985ebb84f523153.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9e8e9c1414cb4a1d8985ebb84f523153"}}, "title": "Depression, anxiety and stress among Swedish university students before and during six months of the COVID-19 pandemic: A cohort study.", "authors": [{"family": "Johansson", "given": "Fred", "initials": "F"}, {"family": "C\u00f4t\u00e9", "given": "Pierre", "initials": "P"}, {"family": "Hogg-Johnson", "given": "Sheilah", "initials": "S"}, {"family": "Rudman", "given": "Ann", "initials": "A"}, {"family": "Holm", "given": "Lena W", "initials": "LW"}, {"family": "Grotle", "given": "Margreth", "initials": "M"}, {"family": "Jensen", "given": "Irene", "initials": "I"}, {"family": "Sundberg", "given": "Tobias", "initials": "T"}, {"family": "Edlund", "given": "Klara", "initials": "K"}, {"family": "Skillgate", "given": "Eva", "initials": "E"}], "type": "journal article", "published": "2021-05-26", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": null, "issue": null, "pages": "14034948211015814"}, "abstract": "The COVID-19 pandemic has had a profound effect on societies and citizens worldwide, raising concerns about potential mental health impacts. We aimed to describe trajectories of depression, anxiety and stress symptoms during the COVID-19 outbreak compared to before the outbreak, and to determine if trajectories were modified by pre-pandemic loneliness, poor sleep quality and mental health problems.\r\n\r\nWe conducted a cohort study with 1836 Swedish university students entering the study before 13 March 2020, the onset of the pandemic, with follow-ups within three (FU1) and six months (FU2) of the outbreak. Generalized Estimating Equations were used to estimate mean differences in symptom levels over time-periods, and to estimate potential effect modifications.\r\n\r\nWe found small differences in mean levels of the depression, anxiety and stress scale (DASS-21) over time. Compared to before the pandemic, depression increased by 0.25 points of 21 (95% CI: 0.04 to -0.45) at FU1 and decreased by 0.75/21 (95% CI:-0.97 to -0.53) at FU2. Anxiety decreased from baseline to FU1 by 0.09/21 (95% CI: -0.24 to -0.07) and by 0.77/21 (95% CI: -0.93 to -0.61) to FU2. Stress decreased from baseline to FU1 by 0.30/21 (95% CI: -0.52 to -0.09) and by 1.32/21 (95% CI: -1.55 to -1.09) to FU2. Students with pre-pandemic loneliness, poor sleep quality or pre-pandemic mental health problems did not have worse trajectories of mean mental health symptoms.\r\n\r\nSymptom levels were relatively stable during the first three months of the pandemic, while there was a slight decrease during the summer months, probably due to seasonality effects.", "doi": "10.1177/14034948211015814", "pmid": "34034577", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-05-29T15:40:53.363Z", "modified": "2021-07-14T09:04:52.922Z"}, {"entity": "publication", "iuid": "ab5e1324aa344ff6a675dd4c0b159a2f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ab5e1324aa344ff6a675dd4c0b159a2f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ab5e1324aa344ff6a675dd4c0b159a2f"}}, "title": "Multiplexed detection of SARS-CoV-2 and other respiratory infections in high throughput by SARSeq.", "authors": [{"family": "Yelagandula", "given": "Ramesh", "initials": "R"}, {"family": "Bykov", "given": "Aleksandr", "initials": "A"}, {"family": "Vogt", "given": "Alexander", "initials": "A"}, {"family": "Heinen", "given": "Robert", "initials": "R"}, {"family": "\u00d6zkan", "given": "Ezgi", "initials": "E"}, {"family": "Strobl", "given": "Marcus Martin", "initials": "MM"}, {"family": "Baar", "given": "Juliane Christina", "initials": "JC"}, {"family": "Uzunova", "given": "Kristina", "initials": "K"}, {"family": "Hajdusits", "given": "Bence", "initials": "B"}, {"family": "Kordic", "given": "Darja", "initials": "D"}, {"family": "Suljic", "given": "Erna", "initials": "E"}, {"family": "Kurtovic-Kozaric", "given": "Amina", "initials": "A"}, {"family": "Izetbegovic", "given": "Sebija", "initials": "S"}, {"family": "Schaeffer", "given": "Justine", "initials": "J"}, {"family": "Hufnagl", "given": "Peter", "initials": "P"}, {"family": "Zoufaly", "given": "Alexander", "initials": "A"}, {"family": "Seitz", "given": "Tamara", "initials": "T"}, {"family": "VCDI", "given": "", "initials": ""}, {"family": "F\u00f6dinger", "given": "Manuela", "initials": "M"}, {"family": "Allerberger", "given": "Franz", "initials": "F"}, {"family": "Stark", "given": "Alexander", "initials": "A"}, {"family": "Cochella", "given": "Luisa", "initials": "L"}, {"family": "Elling", "given": "Ulrich", "initials": "U"}], "type": "journal article", "published": "2021-05-25", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "3132", "issn-l": "2041-1723"}, "abstract": "The COVID-19 pandemic has demonstrated the need for massively-parallel, cost-effective tests monitoring viral spread. Here we present SARSeq, saliva analysis by RNA sequencing, a method to detect SARS-CoV-2 and other respiratory viruses on tens of thousands of samples in parallel. SARSeq relies on next generation sequencing of multiple amplicons generated in a multiplexed RT-PCR reaction. Two-dimensional, unique dual indexing, using four indices per sample, enables unambiguous and scalable assignment of reads to individual samples. We calibrate SARSeq on SARS-CoV-2 synthetic RNA, virions, and hundreds of human samples of various types. Robustness and sensitivity were virtually identical to quantitative RT-PCR. Double-blinded benchmarking to gold standard quantitative-RT-PCR performed by human diagnostics laboratories confirms this high sensitivity. SARSeq can be used to detect Influenza A and B viruses and human rhinovirus in parallel, and can be expanded for detection of other pathogens. Thus, SARSeq is ideally suited for differential diagnostic of infections during a pandemic.", "doi": "10.1038/s41467-021-22664-5", "pmid": "34035246", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-22664-5"}, {"db": "GEO", "key": "GSE163688", "description": "Sequencing data for all experiments"}, {"db": "URL", "key": "https://www.nature.com/articles/s41467-021-22664-5#MOESM5", "description": "Primer sequences"}], "notes": [], "created": "2021-05-29T15:34:33.669Z", "modified": "2021-11-18T13:05:10.873Z"}, {"entity": "publication", "iuid": "e892756c8c4a415f812888a2f2db458a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e892756c8c4a415f812888a2f2db458a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e892756c8c4a415f812888a2f2db458a"}}, "title": "Impact of lockdown and school closure on children's health and well-being during the first wave of COVID-19: a narrative review.", "authors": [{"family": "Rajmil", "given": "Luis", "initials": "L", "orcid": "0000-0002-6625-0649", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96b681441723437abfbe49c7af90af6f.json"}}, {"family": "Hjern", "given": "Anders", "initials": "A"}, {"family": "Boran", "given": "Perran", "initials": "P"}, {"family": "Gunnlaugsson", "given": "Geir", "initials": "G"}, {"family": "Kraus de Camargo", "given": "Olaf", "initials": "O"}, {"family": "Raman", "given": "Shanti", "initials": "S", "orcid": "0000-0002-4546-3231", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8dddb7bcfae9429b864a3ff7cbc06c45.json"}}, {"family": "International Society for Social Pediatrics & Child Health (ISSOP) and International Network for Research on Inequalities in Child Health (INRICH) COVID-19 Working Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-25", "journal": {"title": "BMJ Paediatr Open", "issn": "2399-9772", "issn-l": null, "volume": "5", "issue": "1", "pages": "e001043"}, "abstract": "In the context of containment measures against the COVID-19 pandemic, the aims were to examine the impact of lockdown and school closures on childs' and adolescents' health and well-being and social inequalities in health.\r\n\r\nLiterature review by searching five databases until November 2020. We included quantitative peer-reviewed studies reporting health and well-being outcomes in children (0-18 years) related to closure measures' impact due to COVID-19. A pair of authors assessed the risk of bias of included studies. A descriptive and narrative synthesis was carried out.\r\n\r\nTwenty-two studies, including high-income, middle-income and low-income countries, fulfilled our search criteria and were judged not to have an increased risk of bias. Studies from Australia, Spain and China showed an increase in depressive symptoms and decrease in life satisfaction. A decrease in physical activity and increase in unhealthy food consumption were shown in studies from two countries. There was a decrease in the number of visits to the emergency department in four countries, an increase in child mortality in Cameroon and a decrease by over 50% of immunisations administered in Pakistan. A significant drop of 39% in child protection medical examination referrals during 2020 compared with the previous years was found in the UK, a decrease in allegations of child abuse and neglect by almost one-third due to school closures in Florida, and an increase in the number of children with physical child abuse trauma was found in one centre in the USA.\r\n\r\nFrom available reports, pandemic school closure and lockdown have adverse effects on child health and well-being in the short and probably long term. We urge governments to take the negative public health consequences into account before adopting restrictive measures in childhood.", "doi": "10.1136/bmjpo-2021-001043", "pmid": "34192198", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "bmjpo-2021-001043"}, {"db": "pmc", "key": "PMC8154298"}], "notes": [], "created": "2021-07-05T14:26:37.785Z", "modified": "2022-11-23T09:00:53.996Z"}, {"entity": "publication", "iuid": "e50e510d5bf7459e8e856f436a0df30d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e50e510d5bf7459e8e856f436a0df30d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e50e510d5bf7459e8e856f436a0df30d"}}, "title": "Expanding Utilization of Home Dialysis: An Action Agenda From the First International Home Dialysis Roundtable.", "authors": [{"family": "Mendu", "given": "Mallika L", "initials": "ML"}, {"family": "Divino-Filho", "given": "Jos\u00e9 Carolino", "initials": "JC"}, {"family": "Vanholder", "given": "Raymond", "initials": "R"}, {"family": "Mitra", "given": "Sandip", "initials": "S"}, {"family": "Davies", "given": "Simon J", "initials": "SJ"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Damron", "given": "Kelli Collins", "initials": "KC"}, {"family": "Gallego", "given": "Daniel", "initials": "D"}, {"family": "Seger", "given": "Michelle", "initials": "M"}, {"family": "International Home Dialysis Roundtable Steering Committee", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-25", "journal": {"title": "Kidney Med", "issn": "2590-0595", "volume": "3", "issue": "4", "pages": "635-643", "issn-l": null}, "abstract": "In a groundbreaking meeting, leading global kidney disease organizations came together in the fall of 2020 as an International Home Dialysis Roundtable (IHDR) to address strategies to increase access to and uptake of home dialysis, both peritoneal dialysis and home hemodialysis. This challenge has become urgent in the wake of the coronavirus disease 2019 (COVID-19) pandemic, during which patients with advanced kidney disease, who are more susceptible to viral infections and severe complications, must be able to safely physically distance at home. To boost access to home dialysis on a global scale, IHDR members committed to collaborate, through the COVID-19 public health emergency and beyond, to promote uptake of home dialysis on a broad scale. Their commitments included increasing the reach and influence of key stakeholders with policy makers, building a cooperative of advocates and champions for home dialysis, working together to increase patient engagement and empowerment, and sharing intelligence about policy, education, and other programs so that such efforts can be operationalized globally. In the spirit of international cooperation, IHDR members agreed to document, amplify, and replicate established efforts shown to improve access to home dialysis and support new policies that facilitate access through procedures, innovation, and reimbursement.", "doi": "10.1016/j.xkme.2021.04.004", "pmid": "34401729", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2590-0595(21)00100-X"}, {"db": "pmc", "key": "PMC8350829"}], "notes": [], "created": "2021-08-20T12:16:17.141Z", "modified": "2021-08-20T12:16:31.443Z"}, {"entity": "publication", "iuid": "07a32c0bc5e24434929d4ce6ae95b614", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07a32c0bc5e24434929d4ce6ae95b614.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07a32c0bc5e24434929d4ce6ae95b614"}}, "title": "COVID-19 and the selection problem in national cause-of-death statistics.", "authors": [{"family": "Lindahl", "given": "B I B", "initials": "BIB"}], "type": "journal article", "published": "2021-05-25", "journal": {"title": "Hist Philos Life Sci", "issn": "1742-6316", "volume": "43", "issue": "2", "pages": "72", "issn-l": null}, "abstract": "The World Health Organization has issued international instructions for certification and classification (coding) of the coronavirus disease (COVID-19) as cause of death. Central to these instructions is the selection of the underlying cause of death for a public health preventive purpose. This article focuses on two rules for this selection: (1) that a death due to COVID-19 should be counted independently of pre-existing conditions that are suspected of triggering a severe course of COVID-19 and (2) that COVID-19 should not be considered as due to anything else. The article argues that observance of the first rule may not always lead to an optimal selection from a preventive point of view and that in the future the ascertainment of an animal source of the coronavirus (SARS-CoV-2) would make it possible to reconceptualize 'COVID-19' and create a zoonotic classification code by means of which a factor of a greater preventive value could be selected than what is currently possible.", "doi": "10.1007/s40656-021-00420-8", "pmid": "34036448", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40656-021-00420-8"}], "notes": [], "created": "2021-05-29T15:33:59.474Z", "modified": "2021-05-29T15:33:59.496Z"}, {"entity": "publication", "iuid": "677b5b6503734ac8907936442131505a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/677b5b6503734ac8907936442131505a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/677b5b6503734ac8907936442131505a"}}, "title": "Urinary cytokines correlate with acute kidney injury in critically ill COVID-19 patients.", "authors": [{"family": "Gradin", "given": "A", "initials": "A"}, {"family": "Andersson", "given": "H", "initials": "H"}, {"family": "Luther", "given": "T", "initials": "T"}, {"family": "Anderberg", "given": "S B\u00fclow", "initials": "SB"}, {"family": "Rubertsson", "given": "S", "initials": "S"}, {"family": "Lipcsey", "given": "M", "initials": "M"}, {"family": "\u00c5berg", "given": "M", "initials": "M"}, {"family": "Larsson", "given": "A", "initials": "A"}, {"family": "Frithiof", "given": "R", "initials": "R"}, {"family": "Hultstr\u00f6m", "given": "M", "initials": "M"}], "type": "journal article", "published": "2021-05-24", "journal": {"title": "Cytokine", "issn": "1043-4666", "issn-l": null, "volume": "146", "issue": null, "pages": "155589"}, "abstract": "Acute kidney injury is common in COVID-19 patients admitted to the ICU. Urinary biomarkers are a non-invasive way of assaying renal damage, and so far, urinary cytokines are not fully investigated. The current study aimed to assess urinary cytokine levels in COVID-19 patients.\r\n\r\nUrine was collected from COVID-19 patients (n = 29) in intensive care and compared to a preoperative group of patients (n = 9) with no critical illness. 92 urinary cytokines were analyzed in multiplex using the Olink Target 96 inflammation panel and compared to clinical characteristics, and urinary markers of kidney injury.\r\n\r\nThere were strong correlations between proinflammatory cytokines and between urinary cytokines and urinary kidney injury markers in 29 COVID-19 patients. Several cytokines were correlated to kidney injury, 31 cytokines to AKI stage and 19 cytokines correlated to maximal creatinine.\r\n\r\nUrinary inflammatory cytokines from a wide range of immune cell lineages were significantly upregulated during COVID-19 and the upregulation correlated with acute kidney injury as well as urinary markers of kidney tissue damage.", "doi": "10.1016/j.cyto.2021.155589", "pmid": "34161857", "labels": {"Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pii", "key": "S1043-4666(21)00172-1"}, {"db": "pmc", "key": "PMC8141692"}], "notes": [], "created": "2021-06-21T05:38:51.889Z", "modified": "2021-06-28T17:55:27.612Z"}, {"entity": "publication", "iuid": "fcc09b1d9efd444aae55abf8ed8b4e78", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fcc09b1d9efd444aae55abf8ed8b4e78.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fcc09b1d9efd444aae55abf8ed8b4e78"}}, "title": "Multiple sclerosis and COVID-19: The Swedish experience.", "authors": [{"family": "Landtblom", "given": "Anne-Marie", "initials": "AM"}, {"family": "Berntsson", "given": "Shala G", "initials": "SG"}, {"family": "Bostr\u00f6m", "given": "Inger", "initials": "I"}, {"family": "Iacobaeus", "given": "Ellen", "initials": "E"}], "type": "journal article", "published": "2021-05-24", "journal": {"title": "Acta Neurol Scand", "issn": "1600-0404", "volume": null, "issue": null, "issn-l": null}, "abstract": "The COVID-19 pandemic has brought challenges for healthcare management of patients with multiple sclerosis (MS). Concerns regarding vulnerability to infections and disease-modifying therapies (DMTs) and their complications have been raised. Recent published guidelines on the use of DMTs in relation to COVID-19 in MS patients have been diverse between countries with lack of evidence-based facts. In Sweden, there exists a particular interest in anti-CD20 therapy as a possible risk factor for severe COVID-19 due to the large number of rituximab-treated patients off-label in the country. Rapid responses from the Swedish MS Association (SMSS) and the Swedish MS registry (SMSreg) have resulted in national guidelines on DMT use for MS patients and implementation of a COVID-19 module in the SMSreg. Recently updated guidelines also included recommendations on COVID-19 vaccination with regard to the different DMTs. Social distancing policies forced implementation of telemedicine consultation to replace in-person consultations as part of regular MS health care. Patient-reported outcome measures (PROMs) in SMSreg have been useful in this respect. This paper reports our experiences on the progress of national MS health care during the COVID-19 pandemic, in addition to offering an overview of the present scientific context.", "doi": "10.1111/ane.13453", "pmid": "34028810", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-29T16:22:09.622Z", "modified": "2021-05-29T16:22:09.644Z"}, {"entity": "publication", "iuid": "45dbb9d073a14f418457c5550eb25254", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/45dbb9d073a14f418457c5550eb25254.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/45dbb9d073a14f418457c5550eb25254"}}, "title": "Hospital admission and mortality rates for non-covid diseases in Denmark during covid-19 pandemic: nationwide population based cohort study.", "authors": [{"family": "Bodilsen", "given": "Jacob", "initials": "J"}, {"family": "Nielsen", "given": "Peter Br\u00f8nnum", "initials": "PB"}, {"family": "S\u00f8gaard", "given": "Mette", "initials": "M"}, {"family": "Dalager-Pedersen", "given": "Michael", "initials": "M"}, {"family": "Speiser", "given": "Lasse Ole Zacho", "initials": "LOZ"}, {"family": "Yndigegn", "given": "Troels", "initials": "T"}, {"family": "Nielsen", "given": "Henrik", "initials": "H"}, {"family": "Larsen", "given": "Torben Bjerregaard", "initials": "TB"}, {"family": "Skj\u00f8th", "given": "Flemming", "initials": "F"}], "type": "journal article", "published": "2021-05-24", "journal": {"title": "BMJ", "issn": "1756-1833", "issn-l": null, "volume": "373", "issue": null, "pages": "n1135"}, "abstract": "To determine the incidence of hospital admissions and associated mortality rates for non-covid medical conditions during the covid-19 pandemic.\r\n\r\nNationwide, population based cohort study.\r\n\r\nDenmark from 13 March 2019 to 27 January 2021.\r\n\r\nAll Danish residents >1 year of age.\r\n\r\nPopulation based healthcare registries that encompass the entire Danish population were used to compare hospital admission and mortality rates during the covid-19 pandemic (from 11 March 2020 to 27 January 2021) with the prepandemic baseline data (from 13 March 2019 to 10 March 2020). Hospital admissions were categorised as covid-19 when patients were assigned a diagnosis code for covid-19 within five days of admission. All patients were followed until migration, death, or end of follow-up, whichever came first. Rate ratios for hospital admissions were computed using Poisson regression and were directly standardised using the Danish population on 1 January 2019 as reference. 30 day mortality rate ratios were examined by Cox regression, adjusted for age and sex, and covid-19 diagnosis was used as a competing risk.\r\n\r\n5 753 179 residents were identified during 567.8 million person weeks of observation, with 1 113 705 hospital admissions among 675 447 people. Compared with the prepandemic baseline period (mean hospital admission rate 204.1 per 100 000/week), the overall hospital admission rate for non-covid-19 conditions decreased to 142.8 per 100 000/week (rate ratio 0.70, 95% confidence interval 0.66 to 0.74) after the first national lockdown, followed by a gradual return to baseline levels until the second national lockdown when it decreased to 158.3 per 100 000/week (0.78, 0.73 to 0.82). This pattern was mirrored for most major diagnosis groups except for non-covid-19 respiratory diseases, nervous system diseases, cancer, heart failure, sepsis, and non-covid-19 respiratory infections, which remained lower throughout the study period. Overall 30 day mortality rates were higher during the first national lockdown (mortality rate ratio 1.28, 95% confidence interval 1.23 to 1.32) and the second national lockdown (1.20, 1.16 to 1.24), and these results were similar across most major diagnosis groups. For non-covid-19 respiratory diseases, cancer, pneumonia, and sepsis, the 30 day mortality rate ratios were also higher between lockdown periods.\r\n\r\nHospital admissions for all major non-covid-19 disease groups decreased during national lockdowns compared with the prepandemic baseline period. Additionally, mortality rates were higher overall and for patients admitted to hospital with conditions such as respiratory diseases, cancer, pneumonia, and sepsis. Increased attention towards management of serious non-covid-19 medical conditions is warranted.", "doi": "10.1136/bmj.n1135", "pmid": "34035000", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8142604"}], "notes": [], "created": "2021-05-29T15:40:08.762Z", "modified": "2021-07-14T09:02:41.329Z"}, {"entity": "publication", "iuid": "554af6363be444beb60516c49149884f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/554af6363be444beb60516c49149884f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/554af6363be444beb60516c49149884f"}}, "title": "Hematopoietic stem cell transplantation for autoimmune diseases in the time of COVID-19: EBMT guidelines and recommendations.", "authors": [{"family": "Greco", "given": "Raffaella", "initials": "R"}, {"family": "Alexander", "given": "Tobias", "initials": "T"}, {"family": "Burman", "given": "Joachim", "initials": "J"}, {"family": "Del Papa", "given": "Nicoletta", "initials": "N"}, {"family": "de Vries-Bouwstra", "given": "Jeska", "initials": "J"}, {"family": "Farge", "given": "Dominique", "initials": "D"}, {"family": "Henes", "given": "J\u00f6rg", "initials": "J"}, {"family": "Kazmi", "given": "Majid", "initials": "M"}, {"family": "Kirgizov", "given": "Kirill", "initials": "K"}, {"family": "Muraro", "given": "Paolo A", "initials": "PA"}, {"family": "Ricart", "given": "Elena", "initials": "E"}, {"family": "Rovira", "given": "Montserrat", "initials": "M"}, {"family": "Saccardi", "given": "Riccardo", "initials": "R"}, {"family": "Sharrack", "given": "Basil", "initials": "B"}, {"family": "Snarski", "given": "Emilian", "initials": "E"}, {"family": "Withers", "given": "Barbara", "initials": "B"}, {"family": "Jessop", "given": "Helen", "initials": "H"}, {"family": "Boglione", "given": "Claudia", "initials": "C"}, {"family": "Kramer", "given": "Ellen", "initials": "E"}, {"family": "Badoglio", "given": "Manuela", "initials": "M"}, {"family": "Labopin", "given": "Myriam", "initials": "M"}, {"family": "Orchard", "given": "Kim", "initials": "K"}, {"family": "Corbacioglu", "given": "Selim", "initials": "S"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Mikulska", "given": "Malgorzata", "initials": "M"}, {"family": "De la Camara", "given": "Rafael", "initials": "R"}, {"family": "Snowden", "given": "John A", "initials": "JA"}, {"family": "European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP), Infectious Diseases Working Party (IDWP), Pediatric Working Party (PWP), Joint Accreditation Committee of the International Society for Cellular Therapy (ISCT) and EBMT (JACIE), EBMT Nurses Group and Patient Advocacy Committee", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-24", "journal": {"title": "Bone Marrow Transplant", "issn": "1476-5365", "volume": null, "issue": null, "issn-l": "0268-3369"}, "abstract": "Coronavirus disease-19 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), represents one of the biggest challenges of 21st century, threatening public health around the globe. Increasing age and presence of co-morbidities are reported risk factors for severe disease and mortality, along with autoimmune diseases (ADs) and immunosuppressive treatments such as haematopoietic stem cell transplantation (HSCT), which are also associated with adverse outcomes. We review the impact of the pandemic on specific groups of patients with neurological, rheumatological, and gastroenterological indications, along with the challenges delivering HSCT in adult and pediatric populations. Moving forward, we developed consensus-based guidelines and recommendations for best practice and quality of patient care in order to support clinicians, scientists, and their multidisciplinary teams, as well as patients and their carers. These guidelines aim to support national and international organizations related to autoimmune diseases and local clinical teams delivering HSCT. Areas of unmet need and future research questions are also highlighted. The waves of the COVID-19 pandemic are predicted to be followed by an \"endemic\" phase and therefore an ongoing risk within a \"new normality\". These recommendations reflect currently available evidence, coupled with expert opinion, and will be revised according to necessary modifications in practice.", "doi": "10.1038/s41409-021-01326-6", "pmid": "34031556", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41409-021-01326-6"}, {"db": "pmc", "key": "PMC8143059"}], "notes": [], "created": "2021-05-29T15:41:52.441Z", "modified": "2021-05-29T15:41:52.450Z"}, {"entity": "publication", "iuid": "f9c19d1a5be34893afa3f5aba87ffb50", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f9c19d1a5be34893afa3f5aba87ffb50.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f9c19d1a5be34893afa3f5aba87ffb50"}}, "title": "Health care workers and migrant health: Pre- and post-COVID-19 considerations for reviewing and expanding the research agenda.", "authors": [{"family": "Gunn", "given": "Virginia", "initials": "V"}, {"family": "Somani", "given": "Rozina", "initials": "R"}, {"family": "Muntaner", "given": "Carles", "initials": "C"}], "type": "journal article", "published": "2021-05-24", "journal": {"title": "J Migr Health", "issn": "2666-6235", "volume": "4", "pages": "100048", "issn-l": null}, "abstract": "The main purpose of this article is to review several ways in which health care workers could either impact migrant health or be directly impacted by migration and, based on this, suggest the expansion of the current research agenda on migration and health to address a range of topics that are currently either neglected, insufficiently researched, or researched from different perspectives. To ground this suggestion and emphasize the complexity and significance of migrant health research, we start by briefly reviewing several migration-related notions including the process of migration and its key facilitators and benefits; existing barriers to the provision of migrant health care; and the intricate links between health systems, health professionals, and migrant health. The three areas of research examined in this article address (i) the specific role of health workers in providing care to migrants and refugees and their capacity to do so, (ii) the health problems experienced by health workers who become migrants or refugees, and (iii) the precarious employment conditions experienced by both migrant and non-migrant health care workers. After summarizing the current available evidence on these topics, we discuss key information gaps and strategies to address them, while also incorporating several relevant COVID-19 pandemic considerations and research implications. Expanding the focus of research studies on migration and health could not only enhance the results of current strategies by supplying additional information to support their implementation but also spearhead the development of new solutions to the migrant health problem.", "doi": "10.1016/j.jmh.2021.100048", "pmid": "34405193", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-6235(21)00015-5"}, {"db": "pmc", "key": "PMC8352207"}], "notes": [], "created": "2021-08-20T12:23:05.840Z", "modified": "2021-08-20T12:23:05.852Z"}, {"entity": "publication", "iuid": "cc8277510ec6494b9a70d5e7a955867b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc8277510ec6494b9a70d5e7a955867b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc8277510ec6494b9a70d5e7a955867b"}}, "title": "Challenges in PhD education due to COVID-19 - disrupted supervision or business as usual: a cross-sectional survey of Swedish biomedical sciences graduate students.", "authors": [{"family": "B\u00f6rgeson", "given": "Emma", "initials": "E"}, {"family": "Sotak", "given": "Matus", "initials": "M"}, {"family": "Kraft", "given": "Jamie", "initials": "J"}, {"family": "Bagunu", "given": "Grace", "initials": "G"}, {"family": "Bi\u00f6rserud", "given": "Christina", "initials": "C"}, {"family": "Lange", "given": "Stephan", "initials": "S"}], "type": "journal article", "published": "2021-05-22", "journal": {"title": "BMC Med Educ", "issn": "1472-6920", "volume": "21", "issue": "1", "pages": "294", "issn-l": null}, "abstract": "It remains unclear to what extent the SARS-CoV-2/COVID-19 pandemic disrupted the normal progression of biomedical and medical science graduate programs and if there was a lasting impact on the quality and quantity of supervision of PhD-students. To date, multiple editorials and commentaries indicate the severity of the disruption without providing sufficient evidence with quantifiable data.\n\nAn online survey was submitted to the administrative offices of biomedical and medical PhD-programs at eight major universities in Sweden to gauge the impact of the pandemic on the students. It consisted of multiple-choice and open-ended questions where students could provide examples of positive and/or negative supervision strategies. Open answered questions were coded as either examples of positive or negative support.\n\nPhD students were divided into two groups: those with improved or unchanged supervision during the pandemic (group 1, n = 185), versus those whose supervision worsened (group 2, n = 69). Group 1 received more help from supervisors and more frequent supervision via both online and alternative platforms (email/messages and telephone). There was no significant difference in educational-stage, gender or caretaking responsibilities between the groups.\n\nIt is important for the scientific community to learn how to provide the best possible supervision for PhD students during the pandemic. Our data suggests that more frequent supervision, and using a diverse array of meeting platforms is helpful. In addition, it is important for the students to feel that they have their supervisor's emotional support. Several students also expressed that they would benefit from an extension of their PhD programs due to delays caused by the pandemic.", "doi": "10.1186/s12909-021-02727-3", "pmid": "34022871", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12909-021-02727-3"}, {"db": "pmc", "key": "PMC8140581"}], "notes": [], "created": "2021-05-29T16:23:39.100Z", "modified": "2021-05-29T16:23:39.112Z"}, {"entity": "publication", "iuid": "56750c28d65e4a0c9e2f792150d25e4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56750c28d65e4a0c9e2f792150d25e4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56750c28d65e4a0c9e2f792150d25e4c"}}, "title": "Long term extracorporeal membrane oxygenation bridge to lung transplant after COVID-19.", "authors": [{"family": "Magnusson", "given": "Jesper M", "initials": "JM"}, {"family": "Silverborn", "given": "Martin", "initials": "M"}, {"family": "Broome", "given": "Michael", "initials": "M"}, {"family": "Riise", "given": "Gerdt C", "initials": "GC"}, {"family": "Dellgren", "given": "G\u00f6ran", "initials": "G"}], "type": "case reports", "published": "2021-05-21", "journal": {"title": "Ann Thorac Surg", "issn": "1552-6259", "volume": null, "issue": null, "issn-l": null}, "abstract": "We report a patient with acute respiratory syndrome coronavirus 2 infection and irreversible lung destruction who underwent successful lung transplantation after 138 days of bridging with extracorporeal membrane oxygenation support. The case exemplifies that lung transplantation might be a possibility after very long-term Coronavirus disease 2019 care, even if the patient is initially unsuitable. Patient consent was acquired before writing the case report.", "doi": "10.1016/j.athoracsur.2021.04.092", "pmid": "34029534", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0003-4975(21)00887-0"}, {"db": "pmc", "key": "PMC8139362"}], "notes": [], "created": "2021-05-29T16:20:44.248Z", "modified": "2021-05-29T16:20:59.683Z"}, {"entity": "publication", "iuid": "eb4ec86a74ce44358788f11c359b46b8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb4ec86a74ce44358788f11c359b46b8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb4ec86a74ce44358788f11c359b46b8"}}, "title": "Position statement of the international network for child and family centered care: Child and family centred care during the COVID19 pandemic.", "authors": [{"family": "Al-Motlaq", "given": "Mohammad", "initials": "M"}, {"family": "Neill", "given": "Sarah", "initials": "S"}, {"family": "Foster", "given": "Mandie Jane", "initials": "MJ"}, {"family": "Coyne", "given": "Imelda", "initials": "I"}, {"family": "Houghton", "given": "Davina", "initials": "D"}, {"family": "Angelhoff", "given": "Charlotte", "initials": "C"}, {"family": "Rising-Holmstr\u00f6m", "given": "Malin", "initials": "M"}, {"family": "Majamanda", "given": "Maureen", "initials": "M"}], "type": "journal article", "published": "2021-05-20", "journal": {"title": "J Pediatr Nurs", "issn": "1532-8449", "volume": "61", "issue": null, "pages": "140-143", "issn-l": null}, "abstract": "It is the position of the International Network for Child and Family Centered Care (INCFCC) that COVID19 restrictions pose tremendous challenges for the health care team in their efforts to provide child and family centered care (CFCC). COVID-19 restrictions impact on the family's right to be presernt with their ill child and to contribute to the caring process. A limited number of articles have discussed challenges about the successful delivery of CFCC during the COVID-19 pandemic. Based on current literature, the INCFCC stresses the need for continuous facilitation implementation of child and family centred care as, it is essential for children's physical and psychological wellbeing. Furthermore we believe that the families' presence and participation holds more benefits than risks to the health of children, their families, and the health care team.", "doi": "10.1016/j.pedn.2021.05.002", "pmid": "34052501", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0882-5963(21)00149-4"}], "notes": [], "created": "2021-05-31T16:10:04.873Z", "modified": "2021-05-31T16:10:04.890Z"}, {"entity": "publication", "iuid": "3b5d32446a3444ada161d4e85c38c33d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b5d32446a3444ada161d4e85c38c33d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b5d32446a3444ada161d4e85c38c33d"}}, "title": "Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice", "authors": [{"family": "De Gasparo", "given": "Raoul", "initials": "R"}, {"family": "Pedotti", "given": "Mattia", "initials": "M"}, {"family": "Simonelli", "given": "Luca", "initials": "L"}, {"family": "Nickl", "given": "Petr", "initials": "P", "orcid": "0000-0002-4289-0502", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd09e87cae524e40922a94720a978674.json"}}, {"family": "Muecksch", "given": "Frauke", "initials": "F", "orcid": "0000-0002-0132-5101", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94b175929ad14fec921e737bb3dceda7.json"}}, {"family": "Cassaniti", "given": "Irene", "initials": "I"}, {"family": "Percivalle", "given": "Elena", "initials": "E"}, {"family": "Lorenzi", "given": "Julio C C", "initials": "JCC"}, {"family": "Mazzola", "given": "Federica", "initials": "F"}, {"family": "Magr\u00ec", "given": "Davide", "initials": "D", "orcid": "0000-0003-3790-5332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15cedaba7cb3438fad6c71e2a015921e.json"}}, {"family": "Michalcikova", "given": "Tereza", "initials": "T"}, {"family": "Haviernik", "given": "Jan", "initials": "J"}, {"family": "Honig", "given": "Vaclav", "initials": "V", "orcid": "0000-0003-0469-4604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65499eafa5a24320b87d2534f4dcf99a.json"}}, {"family": "Mrazkova", "given": "Blanka", "initials": "B"}, {"family": "Polakova", "given": "Natalie", "initials": "N"}, {"family": "Fortova", "given": "Andrea", "initials": "A"}, {"family": "Tureckova", "given": "Jolana", "initials": "J"}, {"family": "Iatsiuk", "given": "Veronika", "initials": "V"}, {"family": "Di Girolamo", "given": "Salvatore", "initials": "S"}, {"family": "Palus", "given": "Martin", "initials": "M"}, {"family": "Zudova", "given": "Dagmar", "initials": "D"}, {"family": "Bednar", "given": "Petr", "initials": "P"}, {"family": "Bukova", "given": "Ivana", "initials": "I"}, {"family": "Bianchini", "given": "Filippo", "initials": "F"}, {"family": "Mehn", "given": "Dora", "initials": "D"}, {"family": "Nencka", "given": "Radim", "initials": "R"}, {"family": "Strakova", "given": "Petra", "initials": "P"}, {"family": "Pavlis", "given": "Oto", "initials": "O"}, {"family": "Rozman", "given": "Jan", "initials": "J", "orcid": "0000-0002-8035-8904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69dca82b58b8449c8af3e096813d6003.json"}}, {"family": "Gioria", "given": "Sabrina", "initials": "S"}, {"family": "Sammartino", "given": "Jos\u00e8 Camilla", "initials": "JC"}, {"family": "Giardina", "given": "Federica", "initials": "F"}, {"family": "Gaiarsa", "given": "Stefano", "initials": "S"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q", "orcid": "0000-0003-1990-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94a32366862b470eba3a15521b9be290.json"}}, {"family": "Barnes", "given": "Christopher O", "initials": "CO"}, {"family": "Bjorkman", "given": "Pamela J", "initials": "PJ", "orcid": "0000-0002-2277-3990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65549e18865046ac99cfee9f969c2759.json"}}, {"family": "Calzolai", "given": "Luigi", "initials": "L", "orcid": "0000-0002-8474-7974", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e3a67661994a48e28a8279fb27346285.json"}}, {"family": "Piralla", "given": "Antonio", "initials": "A", "orcid": "0000-0002-6062-2579", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af56fb1bc11f43d9861faa71c5b50043.json"}}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Nussenzweig", "given": "Michel C", "initials": "MC"}, {"family": "Bieniasz", "given": "Paul D", "initials": "PD", "orcid": "0000-0002-2368-3719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72f7075120214d4091202cd80ffbe506.json"}}, {"family": "Hatziioannou", "given": "Theodora", "initials": "T"}, {"family": "Prochazka", "given": "Jan", "initials": "J"}, {"family": "Sedlacek", "given": "Radislav", "initials": "R", "orcid": "0000-0002-3352-392X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a1594084f604610a995def1f7a6bdb2.json"}}, {"family": "Robbiani", "given": "Davide F", "initials": "DF", "orcid": "0000-0001-7379-3484", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/941e237779f74a568228c6fe1ee8800c.json"}}, {"family": "Ruzek", "given": "Daniel", "initials": "D", "orcid": "0000-0003-4655-2380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f49c5724719433ea99ebf38a4ff4a58.json"}}, {"family": "Varani", "given": "Luca", "initials": "L", "orcid": "0000-0002-0963-0987", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6c4a4cecfc04659b3b8df2b49430ba6.json"}}], "type": "journal-article", "published": "2021-05-20", "journal": {"title": "Nature", "issn": "0028-0836", "issn-l": null, "volume": "593", "issue": "7859", "pages": "424-428"}, "abstract": "Neutralizing antibodies targeting the receptor binding domain (RBD) of the SARS-CoV-2 Spike (S) are among the most promising approaches against coronavirus disease 2019 (COVID-19) 1,2 . We developed a bispecific, IgG1-like molecule based on two antibodies derived from COVID-19 convalescent donors, C121 and C135 3 . CoV-X2 simultaneously binds two independent sites on the RBD and, unlike its parental antibodies, completely prevents S binding to Angiotensin-Converting Enzyme 2 (ACE2), the virus cellular receptor. Furthermore, CoV-X2 recognizes a broad panel of RBD variants and neutralizes SARS-CoV-2 and the escape mutants generated by the single monoclonals at sub-nanomolar concentrations. In a novel model of SARS-CoV-2 infection with lung inflammation, CoV-X2 protects mice from disease and suppresses viral escape. Thus, simultaneous targeting of non-overlapping RBD epitopes by IgG-like bispecific antibodies is feasible and effective, combining into a single molecule the advantages of antibody cocktails.", "doi": "10.1038/s41586-021-03461-y", "pmid": "33501434", "labels": {"Category: Biochemistry": null, "Funder: H2020": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-18T11:10:09.811Z", "modified": "2021-06-18T11:01:30.134Z"}, {"entity": "publication", "iuid": "5e3db02127264d2e8c356e9bff7ad2dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e3db02127264d2e8c356e9bff7ad2dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e3db02127264d2e8c356e9bff7ad2dd"}}, "title": "Authors' Reply to: COVID-19 as a \"Force Majeure\" for Non-COVID-19 Clinical and Translational Research. Comment on \"Analysis of Scientific Publications During the Early Phase of the COVID-19 Pandemic: Topic Modeling Study\".", "authors": [{"family": "\u00c4lg\u00e5", "given": "Andreas", "initials": "A"}, {"family": "Eriksson", "given": "Oskar", "initials": "O"}, {"family": "Nordberg", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2021-05-20", "journal": {"title": "J Med Internet Res", "issn": "1438-8871", "volume": "23", "issue": "5", "pages": "e29156", "issn-l": null}, "abstract": null, "doi": "10.2196/29156", "pmid": "33989170", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "v23i5e29156"}], "notes": [], "created": "2021-05-21T17:02:08.259Z", "modified": "2021-05-21T17:03:39.189Z"}, {"entity": "publication", "iuid": "c3e66e3c5ab449bfb3c028254e5038fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3e66e3c5ab449bfb3c028254e5038fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3e66e3c5ab449bfb3c028254e5038fc"}}, "title": "Systematic Organization of COVID-19 Data Supported by the Adverse Outcome Pathway Framework.", "authors": [{"family": "Nymark", "given": "Penny", "initials": "P"}, {"family": "Sachana", "given": "Magdalini", "initials": "M"}, {"family": "Leite", "given": "Sofia Batista", "initials": "SB"}, {"family": "Sund", "given": "Jukka", "initials": "J"}, {"family": "Krebs", "given": "Catharine E", "initials": "CE"}, {"family": "Sullivan", "given": "Kristie", "initials": "K"}, {"family": "Edwards", "given": "Stephen", "initials": "S"}, {"family": "Viviani", "given": "Laura", "initials": "L"}, {"family": "Willett", "given": "Catherine", "initials": "C"}, {"family": "Landesmann", "given": "Brigitte", "initials": "B"}, {"family": "Wittwehr", "given": "Clemens", "initials": "C"}], "type": "journal article", "published": "2021-05-19", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "9", "issue": null, "pages": "638605"}, "abstract": "Adverse Outcome Pathways (AOP) provide structured frameworks for the systematic organization of research data and knowledge. The AOP framework follows a set of key principles that allow for broad application across diverse disciplines related to human health, including toxicology, pharmacology, virology and medical research. The COVID-19 pandemic engages a great number of scientists world-wide and data is increasing with exponential speed. Diligent data management strategies are employed but approaches for systematically organizing the data-derived information and knowledge are lacking. We believe AOPs can play an important role in improving interpretation and efficient application of scientific understanding of COVID-19. Here, we outline a newly initiated effort, the CIAO project (https://www.ciao-covid.net/), to streamline collaboration between scientists across the world toward development of AOPs for COVID-19, and describe the overarching aims of the effort, as well as the expected outcomes and research support that they will provide.", "doi": "10.3389/fpubh.2021.638605", "pmid": "34095051", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8170012"}], "notes": [], "created": "2021-06-08T08:49:30.261Z", "modified": "2021-06-08T08:53:33.409Z"}, {"entity": "publication", "iuid": "b4930e10644a4b13aa604f7263c2888b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b4930e10644a4b13aa604f7263c2888b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b4930e10644a4b13aa604f7263c2888b"}}, "title": "Social media for field epidemiologists (#SoMe4epis): How to use Twitter during the #COVID19 pandemic.", "authors": [{"family": "Hammer", "given": "Charlotte C", "initials": "CC"}, {"family": "Boender", "given": "T Sonia", "initials": "TS"}, {"family": "Thomas", "given": "Daniel Rh", "initials": "DR"}], "type": "journal article", "published": "2021-05-19", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic has fundamentally changed the way that public health professionals work and communicate. Over a very short time span, remote working arrangements have become the norm, and meetings have shifted online. Physical distancing measures have accelerated a trend toward digital communication and social exchange. At the same time, the work of epidemiologists has been held under a magnifying glass by journalists, governments and the general public, in a way not previously seen. As social media have become an inevitable part of our society over the last decade, Twitter has become a key communication tool and platform for social networking among epidemiologists (#EpiTwitter). In this article we reflect on the use of Twitter by field epidemiologists and public health microbiologists for rapid professional exchange, public communication of science, and professional development during the pandemic, as well as the associated risks. For those field epidemiologists new to social media, we discuss how Twitter can be used in a variety of ways, both at their home institutions and during field deployment. These include: information dissemination, science communication and public health advocacy, professional development, networking and experience exchange.", "doi": "10.1016/j.ijid.2021.05.035", "pmid": "34022332", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)00437-9"}], "notes": [], "created": "2021-05-29T16:24:31.698Z", "modified": "2022-11-22T05:47:08.310Z"}, {"entity": "publication", "iuid": "47be8642a1d3402f8d7f81aab73f8a34", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47be8642a1d3402f8d7f81aab73f8a34.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47be8642a1d3402f8d7f81aab73f8a34"}}, "title": "Gender and Entrepreneurship in Pandemic Time: What Demands and What Resources? An Exploratory Study.", "authors": [{"family": "De Simone", "given": "Silvia", "initials": "S"}, {"family": "Pileri", "given": "Jessica", "initials": "J"}, {"family": "Rapp-Ricciardi", "given": "Max", "initials": "M"}, {"family": "Barbieri", "given": "Barbara", "initials": "B"}], "type": "journal article", "published": "2021-05-19", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "issue": null, "pages": "668875", "issn-l": "1664-1078"}, "abstract": "Due to the coronavirus disease 2019 (COVID-19) epidemic, global economies have suffered an exogenous shock never seen before with a strong economic and psychosocial impact on organizations. Italy, in the context of the research, has been severely affected. The economic crisis has mainly affected women. In this scenario, entrepreneurial perceived success (objective and subjective) is influenced by increasingly burdensome job demands that entrepreneurs have to face up. Using the job demand-resources model, the study aims to broaden the knowledge of the determinants of entrepreneurial perceived success in the current emergency moment. In particular, as regards of the demands, alongside the specific entrepreneurial demands (time demands, uncertainty and risk, and responsibility), we also decided to include the negative interface family-work in both directions from-family-to-work (NEGWIF) and from-work-to-family (NEGFIW). Regarding the resources, we considered entrepreneurial self-efficacy (researching, planning, marshaling, implementing people, and implementing financial), proactive and elaborate social strategies (SS), and both directions of the positive interface: from-family-to-work (POSWIF) and from-work-to-family (POSFIW). All participants are women entrepreneurs ( N = 137) who have completed a self-report questionnaire. We explored the associations between demands, resources, and the dimensions of success through hierarchical regressions. As for the demands, time demands, uncertainty and risk, NEGWIF, and NEGFIW negatively influenced the perceived entrepreneurial success. Regarding resources, planning, implementing financial, proactive and elaborate SS positively influenced the perceived entrepreneurial success.", "doi": "10.3389/fpsyg.2021.668875", "pmid": "34093367", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8170095"}], "notes": [], "created": "2021-06-08T08:48:31.709Z", "modified": "2021-06-08T08:48:31.719Z"}, {"entity": "publication", "iuid": "2292c98cfe14465294b658610e6fc3a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2292c98cfe14465294b658610e6fc3a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2292c98cfe14465294b658610e6fc3a1"}}, "title": "A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection.", "authors": [{"family": "Miller", "given": "Ami", "initials": "A"}, {"family": "Leach", "given": "Adam", "initials": "A"}, {"family": "Thomas", "given": "Jemima", "initials": "J"}, {"family": "McAndrew", "given": "Craig", "initials": "C"}, {"family": "Bentley", "given": "Emma", "initials": "E"}, {"family": "Mattiuzzo", "given": "Giada", "initials": "G"}, {"family": "John", "given": "Lijo", "initials": "L"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Harris", "given": "Gemma", "initials": "G"}, {"family": "Gamage", "given": "Nadisha", "initials": "N"}, {"family": "Carr", "given": "Stephen", "initials": "S"}, {"family": "Ali", "given": "Hanif", "initials": "H"}, {"family": "Van Montfort", "given": "Rob", "initials": "R"}, {"family": "Rabbitts", "given": "Terence", "initials": "T"}], "type": "journal article", "published": "2021-05-19", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "10617", "issn-l": "2045-2322"}, "abstract": "Approaches are needed for therapy of the severe acute respiratory syndrome from SARS-CoV-2 coronavirus (COVID-19). Interfering with the interaction of viral antigens with the angiotensin converting enzyme 2 (ACE-2) receptor is a promising strategy by blocking the infection of the coronaviruses into human cells. We have implemented a novel protein engineering technology to produce a super-potent tetravalent form of ACE2, coupled to the human immunoglobulin \u03b31 Fc region, using a self-assembling, tetramerization domain from p53 protein. This high molecular weight Quad protein (ACE2-Fc-TD) retains binding to the SARS-CoV-2 receptor binding spike protein and can form a complex with the spike protein plus anti-viral antibodies. The ACE2-Fc-TD acts as a powerful decoy protein that out-performs soluble monomeric and dimeric ACE2 proteins and blocks both SARS-CoV-2 pseudovirus and SARS-CoV-2 virus infection with greatly enhanced efficacy. The ACE2 tetrameric protein complex promise to be important for development as decoy therapeutic proteins against COVID-19. In contrast to monoclonal antibodies, ACE2 decoy is unlikely to be affected by mutations in SARS-CoV-2 that are beginning to appear in variant forms. In addition, ACE2 multimeric proteins will be available as therapeutic proteins should new coronaviruses appear in the future because these are likely to interact with ACE2 receptor.", "doi": "10.1038/s41598-021-89957-z", "pmid": "34012108", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-89957-z"}], "notes": [], "created": "2021-05-21T17:17:53.522Z", "modified": "2021-05-21T17:19:09.667Z"}, {"entity": "publication", "iuid": "0d0890dfdb014f09ae619216e6d0d2a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d0890dfdb014f09ae619216e6d0d2a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d0890dfdb014f09ae619216e6d0d2a2"}}, "title": "Type-I interferon signatures in SARS-CoV-2 infected Huh7 cells.", "authors": [{"family": "Chen", "given": "Xi", "initials": "X"}, {"family": "Saccon", "given": "Elisa", "initials": "E"}, {"family": "Appelberg", "given": "K Sofia", "initials": "KS"}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "Rodriguez", "given": "Jimmy Esneider", "initials": "JE"}, {"family": "Vinhas", "given": "Beatriz S\u00e1", "initials": "BS"}, {"family": "Frisan", "given": "Teresa", "initials": "T"}, {"family": "V\u00e9gv\u00e1ri", "given": "\u00c1kos", "initials": "\u00c1"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}, {"family": "Gupta", "given": "Soham", "initials": "S"}], "type": "journal article", "published": "2021-05-18", "journal": {"title": "Cell Death Discov", "issn": "2058-7716", "issn-l": null, "volume": "7", "issue": "1", "pages": "114"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes Coronavirus disease 2019 (COVID-19) has caused a global health emergency. A key feature of COVID-19 is dysregulated interferon-response. Type-I interferon (IFN-I) is one of the earliest antiviral innate immune responses following viral infection and plays a significant role in the pathogenesis of SARS-CoV-2. In this study, using a proteomics-based approach, we identified that SARS-CoV-2 infection induces delayed and dysregulated IFN-I signaling in Huh7 cells. We demonstrate that SARS-CoV-2 is able to inhibit RIG-I mediated IFN-\u03b2 production. Our results also confirm the recent findings that IFN-I pretreatment is able to reduce the susceptibility of Huh7 cells to SARS-CoV-2, but not post-treatment. Moreover, senescent Huh7 cells, in spite of showing accentuated IFN-I response were more susceptible to SARS-CoV-2 infection, and the virus effectively inhibited IFIT1 in these cells. Finally, proteomic comparison between SARS-CoV-2, SARS-CoV, and MERS-CoV revealed a distinct differential regulatory signature of interferon-related proteins emphasizing that therapeutic strategies based on observations in SARS-CoV and MERS-CoV should be used with caution. Our findings provide a better understanding of SARS-CoV-2 regulation of cellular interferon response and a perspective on its use as a treatment. Investigation of different interferon-stimulated genes and their role in the inhibition of SARS-CoV-2 pathogenesis may direct novel antiviral strategies.", "doi": "10.1038/s41420-021-00487-z", "pmid": "34006825", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41420-021-00487-z"}, {"db": "URL", "key": "https://github.com/neogilab/COVID_IFN", "description": "Codes generated in analyzing the data"}, {"db": "URL", "key": "http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD023450", "description": "ProteomeXhanger Consortium, PXD023450"}], "notes": [], "created": "2021-05-20T14:42:46.846Z", "modified": "2021-06-04T14:47:25.536Z"}, {"entity": "publication", "iuid": "1ee5e839575a4c60a617878c3cab93bc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ee5e839575a4c60a617878c3cab93bc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ee5e839575a4c60a617878c3cab93bc"}}, "title": "Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers.", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Rosell", "given": "Axel", "initials": "A"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Mangsbo", "given": "Sara M", "initials": "SM"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2021-05-18", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484", "volume": "325", "issue": "19", "pages": "2015-2016"}, "abstract": "This cohort study describes COVID-19\u2013related symptoms persisting 8 months after SARS-CoV-2 infection among Swedish health care workers and self-reported effects of the residual symptoms on respondents\u2019 home, work, and social function.", "doi": "10.1001/jama.2021.5612", "pmid": "33825846", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC8027932"}, {"db": "pii", "key": "2778528"}], "notes": [], "created": "2021-04-09T09:00:37.481Z", "modified": "2023-01-13T13:26:19.203Z"}, {"entity": "publication", "iuid": "427d81e50b244080b398a3346744fcec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/427d81e50b244080b398a3346744fcec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/427d81e50b244080b398a3346744fcec"}}, "title": "Seropositivity in blood donors and pregnant women during the first year of SARS-CoV-2 transmission in Stockholm, Sweden.", "authors": [{"family": "Castro Dopico", "given": "X", "initials": "X"}, {"family": "Muschiol", "given": "S", "initials": "S"}, {"family": "Christian", "given": "M", "initials": "M"}, {"family": "Hanke", "given": "L", "initials": "L"}, {"family": "Sheward", "given": "D J", "initials": "DJ"}, {"family": "Grinberg", "given": "N F", "initials": "NF"}, {"family": "Rorbach", "given": "J", "initials": "J"}, {"family": "Bogdanovic", "given": "G", "initials": "G"}, {"family": "Mcinerney", "given": "G M", "initials": "GM"}, {"family": "Allander", "given": "T", "initials": "T"}, {"family": "Wallace", "given": "C", "initials": "C"}, {"family": "Murrell", "given": "B", "initials": "B"}, {"family": "Albert", "given": "J", "initials": "J"}, {"family": "Karlsson Hedestam", "given": "G B", "initials": "GB"}], "type": "journal article", "published": "2021-05-18", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "In Sweden, social restrictions to contain SARS-CoV-2 have primarily relied upon voluntary adherence to a set of recommendations. Strict lockdowns have not been enforced, potentially affecting viral dissemination. To understand the levels of past SARS-CoV-2 infection in the Stockholm population before the start of mass vaccinations, healthy blood donors and pregnant women (n = 5,100) were sampled at random between 14 March 2020 and 28 February 2021.\r\n\r\nIn this cross-sectional prospective study, otherwise-healthy blood donors (n = 2,600) and pregnant women (n = 2,500) were sampled for consecutive weeks (at four intervals) throughout the study period. Sera from all participants and a cohort of historical (negative) controls (n = 595) were screened for IgG responses against stabilized trimers of the SARS-CoV-2 spike (S) glycoprotein and the smaller receptor-binding domain (RBD). As a complement to standard analytical approaches, a probabilistic (cut-off independent) Bayesian framework that assigns likelihood of past infection was used to analyse data over time.\r\n\r\nHealthy participant samples were randomly selected from their respective pools through Karolinska University Hospital. The study was carried out in accordance with Swedish Ethical Review Authority: registration number 2020-01807.\r\n\r\nNo participants were symptomatic at sampling, and blood donors were all over the age of 18. No additional metadata were available from the participants.\r\n\r\nBlood donors and pregnant women showed a similar seroprevalence. After a steep rise at the start of the pandemic, the seroprevalence trajectory increased steadily in approach to the winter second wave of infections, approaching 15% of all individuals surveyed by 13 December 2020. By the end of February 2021, 19% of the population tested seropositive. Notably, 96% of seropositive healthy donors screened (n = 56) developed neutralizing antibody responses at titres comparable to or higher than those observed in clinical trials of SARS-CoV-2 spike mRNA vaccination, supporting that mild infection engenders a competent B-cell response.\r\n\r\nThese data indicate that in the first year since the start of community transmission, seropositivity levels in metropolitan in Stockholm had reached approximately one in five persons, providing important baseline seroprevalence information prior to the start of vaccination.", "doi": "10.1111/joim.13304", "pmid": "34008203", "labels": {"Type: Journal article": null, "Category: Serology": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-20T14:40:09.375Z", "modified": "2021-06-18T08:55:05.225Z"}, {"entity": "publication", "iuid": "acb58f22ba544e3986bb4e8945638319", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/acb58f22ba544e3986bb4e8945638319.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/acb58f22ba544e3986bb4e8945638319"}}, "title": "Living with an ever-present breathlessness: Women's experiences of living with chronic obstructive pulmonary disease stage III or IV.", "authors": [{"family": "Ekdahl", "given": "Ann", "initials": "A"}, {"family": "S\u00f6derberg", "given": "Siv", "initials": "S"}, {"family": "Rising-Holmstr\u00f6m", "given": "Malin", "initials": "M"}], "type": "journal article", "published": "2021-05-18", "journal": {"title": "Scand J Caring Sci", "issn": "1471-6712", "volume": null, "issue": null, "issn-l": null}, "abstract": "Living with chronic obstructive pulmonary disease stage III or IV has a major impact on a person's everyday life. This qualitative study focuses on women with chronic obstructive pulmonary disease stage III or IV.\n\nThe aim of this study was to describe women's experiences of living with chronic obstructive pulmonary disease stage III or IV.\n\nA purposive sample of fifteen women with chronic obstructive pulmonary disease stage III or IV participated in the study. Data were collected through individual semi-structured interviews that were subjected to qualitative content analysis.\n\nOne theme was identified, stabilizing an ever-present breathlessness by restoring strength, and three categories are as follows: managing a restricted everyday life as an expert of their illness, being afraid of contracting infections leading to suffocation and suffering and importance of continuous help and support from significant others and digital media. Breathlessness restricted women with chronic obstructive pulmonary disease, living with a body they have to wait for. Managing everyday life was adapted to their limited abilities and energy. This required detailed planning, good knowledge of their breathing and body. Women were afraid of contracting life-threatening infections that caused suffering, especially COVID-19. The fear leads to isolation and digital media was described as an important means of communication. Significant others gave support and help that was practical and emotional. Women with chronic obstructive pulmonary disease experienced lack of continuous help and support from healthcare professionals.\n\nStabilizing an ever-present breathlessness by restoring strength required women with chronic obstructive pulmonary disease stage III or IV to conduct detailed planning to manage everyday life. Being afraid of contracting infections and the consequences of suffocation had increased since the pandemic COVID-19 outbreak, which led to self-isolation and an inactive everyday life. To get help, support and socialize, women used digital media.", "doi": "10.1111/scs.12998", "pmid": "34008226", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-20T14:38:38.418Z", "modified": "2021-05-21T17:12:48.720Z"}, {"entity": "publication", "iuid": "0f2ef23eea074d47af6dfa8672fa32c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0f2ef23eea074d47af6dfa8672fa32c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0f2ef23eea074d47af6dfa8672fa32c5"}}, "title": "[Rare but potentially life-threatening - Multisystem inflammatory syndrome in adults - a case description].", "authors": [{"family": "Berntson", "given": "Lillemor", "initials": "L"}, {"family": "von Seth", "given": "Magnus", "initials": "M"}, {"family": "B\u00fclow Anderberg", "given": "Sara", "initials": "S"}, {"family": "\u00c5kerstr\u00f6m", "given": "Tobias", "initials": "T"}, {"family": "Kurland", "given": "Siri", "initials": "S"}], "type": "case reports", "published": "2021-05-17", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "118", "issue": null, "pages": null}, "abstract": "Multisystem inflammatory syndrome in adults, MIS-A, is a rare but severe post-covid-19 immunologic complication. The presentation is similar to Multisystem inflammatory syndrome in children, MIS-C. Both MIS-A/C are life-threatening immunologic syndromes characterized by hypotension, skin rashes, myocardial affection, coagulopathy and GI symptoms. Here we describe a case of MIS-A in a 35-year-old previously healthy female who, five weeks after a mild covid-19 infection, presented with a life-threatening immunological reaction. The patient made a swift recovery upon treatment with immunoglobulins, corticosteroids and an interleukin-1 receptor antagonist. We want to highlight the importance of immunological derangements following covid-19 infections in adults. We also present a treatment suggestion for MIS-A based on the management routine for MIS-C, which has been developed from international discussions and collaborations by pediatric rheumatologists in Sweden and around the world.", "doi": null, "pmid": "33999400", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "21084"}], "notes": [], "created": "2021-05-21T16:58:51.071Z", "modified": "2021-07-09T12:34:21.741Z"}, {"entity": "publication", "iuid": "8e377d87e6a14ef796a22a4cd6edc9a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e377d87e6a14ef796a22a4cd6edc9a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e377d87e6a14ef796a22a4cd6edc9a9"}}, "title": "Reorganisation of GP surgeries during the COVID-19 outbreak: analysis of guidelines from 15 countries.", "authors": [{"family": "Tsopra", "given": "Rosy", "initials": "R"}, {"family": "Frappe", "given": "Paul", "initials": "P"}, {"family": "Streit", "given": "Sven", "initials": "S"}, {"family": "Neves", "given": "Ana Luisa", "initials": "AL"}, {"family": "Honkoop", "given": "Persijn J", "initials": "PJ"}, {"family": "Espinosa-Gonzalez", "given": "Ana Belen", "initials": "AB"}, {"family": "Gero\u011flu", "given": "Berk", "initials": "B"}, {"family": "Jahr", "given": "Tobias", "initials": "T"}, {"family": "Lingner", "given": "Heidrun", "initials": "H"}, {"family": "Nessler", "given": "Katarzyna", "initials": "K"}, {"family": "Pesolillo", "given": "Gabriella", "initials": "G"}, {"family": "Sivertsen", "given": "\u00d8yvind Stople", "initials": "\u00d8S"}, {"family": "Thulesius", "given": "Hans", "initials": "H"}, {"family": "Zoitanu", "given": "Raluca", "initials": "R"}, {"family": "Burgun", "given": "Anita", "initials": "A"}, {"family": "Kinouani", "given": "Sh\u00e9razade", "initials": "S"}], "type": "journal article", "published": "2021-05-17", "journal": {"title": "BMC Fam Pract", "issn": "1471-2296", "volume": "22", "issue": "1", "pages": "96", "issn-l": null}, "abstract": "General practitioners (GPs) play a key role in managing the COVID-19 outbreak. However, they may encounter difficulties adapting their practices to the pandemic. We provide here an analysis of guidelines for the reorganisation of GP surgeries during the beginning of the pandemic from 15 countries.\n\nA network of GPs collaborated together in a three-step process: (i) identification of key recommendations of GP surgery reorganisation, according to WHO, CDC and health professional resources from health care facilities; (ii) collection of key recommendations included in the guidelines published in 15 countries; (iii) analysis, comparison and synthesis of the results.\n\nRecommendations for the reorganisation of GP surgeries of four types were identified: (i) reorganisation of GP consultations (cancelation of non-urgent consultations, follow-up via e-consultations), (ii) reorganisation of GP surgeries (area partitioning, visual alerts and signs, strict hygiene measures), (iii) reorganisation of medical examinations by GPs (equipment, hygiene, partial clinical examinations, patient education), (iv) reorganisation of GP staff (equipment, management, meetings, collaboration with the local community).\n\nWe provide here an analysis of guidelines for the reorganisation of GP surgeries during the beginning of the COVID-19 outbreak from 15 countries. These guidelines focus principally on clinical care, with less attention paid to staff management, and the area of epidemiological surveillance and research is largely neglected. The differences of guidelines between countries and the difficulty to apply them in routine care, highlight the need of advanced research in primary care. Thereby, primary care would be able to provide recommendations adapted to the real-world settings and with stronger evidence, which is especially necessary during pandemics.", "doi": "10.1186/s12875-021-01413-z", "pmid": "34000985", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12875-021-01413-z"}], "notes": [], "created": "2021-05-20T14:57:16.242Z", "modified": "2021-05-21T16:53:15.785Z"}, {"entity": "publication", "iuid": "d9f1933746cc4b67a5a451049cc1bf1a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d9f1933746cc4b67a5a451049cc1bf1a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d9f1933746cc4b67a5a451049cc1bf1a"}}, "title": "Interruption of cancer screening services due to COVID-19 pandemic: lessons from previous disasters.", "authors": [{"family": "Puricelli Perin", "given": "Douglas M", "initials": "DM"}, {"family": "Christensen", "given": "Tess", "initials": "T"}, {"family": "Bur\u00f3n", "given": "Andrea", "initials": "A"}, {"family": "Haas", "given": "Jennifer S", "initials": "JS"}, {"family": "Kamineni", "given": "Aruna", "initials": "A"}, {"family": "Pashayan", "given": "Nora", "initials": "N"}, {"family": "Rabeneck", "given": "Linda", "initials": "L"}, {"family": "Smith", "given": "Robert", "initials": "R"}, {"family": "Elfstr\u00f6m", "given": "Miriam", "initials": "M"}, {"family": "Broeders", "given": "Mireille J M", "initials": "MJM"}, {"family": "International Cancer Screening Network ICSN", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-17", "journal": {"title": "Prev Med Rep", "issn": "2211-3355", "volume": null, "issue": null, "pages": "101399", "issn-l": null}, "abstract": "To review the scientific literature seeking lessons for the COVID-19 era that could be learned from previous health services interruptions that affected the delivery of cancer screening services.\n\nA systematic search was conducted up to April 17, 2020, with no restrictions on language or dates and resulted in 385 articles. Two researchers independently assessed the list and discussed any disagreements. Once a consensus was achieved for each paper, those selected were included in the review.\n\nEleven articles were included. Three studies were based in Japan, two in the United States, one in South Korea, one in Denmark, and the remaining four offered a global perspective on interruptions in health services due to natural or human-caused disasters. No articles covered an interruption due to a pandemic. The main themes identified in the reviewed studies were coordination, communication, resource availability and patient follow-up.\n\nLessons learned applied to the context of COVID-19 are that coordination involving partners across the health sector is essential to optimize resources and resume services, making them more resilient while preparing for future interruptions. Communication with the general population about how COVID-19 has affected cancer screening, measures taken to mitigate it and safely re-establish screening services is recommended. Use of mobile health systems to reach patients who are not accessing services and the application of resource-stratified guidelines are important considerations. More research is needed to explore best strategies for suspending, resuming and sustaining cancer screening programs, and preparedness for future disruptions, adapted to diverse health care systems.", "doi": "10.1016/j.pmedr.2021.101399", "pmid": "34026465", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2211-3355(21)00089-9"}, {"db": "pmc", "key": "PMC8126519"}], "notes": [], "created": "2021-05-29T16:23:10.213Z", "modified": "2021-05-29T16:23:10.235Z"}, {"entity": "publication", "iuid": "c8c1fc225e9c47ccbc1e8ef4853d31b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c8c1fc225e9c47ccbc1e8ef4853d31b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c8c1fc225e9c47ccbc1e8ef4853d31b3"}}, "title": "Global effect of COVID-19 pandemic on physical activity, sedentary behaviour and sleep among 3- to 5-year-old children: a longitudinal study of 14 countries.", "authors": [{"family": "Okely", "given": "Anthony D", "initials": "AD"}, {"family": "Kariippanon", "given": "Katharina E", "initials": "KE"}, {"family": "Guan", "given": "Hongyan", "initials": "H"}, {"family": "Taylor", "given": "Ellie K", "initials": "EK"}, {"family": "Suesse", "given": "Thomas", "initials": "T"}, {"family": "Cross", "given": "Penny L", "initials": "PL"}, {"family": "Chong", "given": "Kar Hau", "initials": "KH"}, {"family": "Suherman", "given": "Adang", "initials": "A"}, {"family": "Turab", "given": "Ali", "initials": "A"}, {"family": "Staiano", "given": "Amanda E", "initials": "AE"}, {"family": "Ha", "given": "Amy S", "initials": "AS"}, {"family": "El Hamdouchi", "given": "Asmaa", "initials": "A"}, {"family": "Baig", "given": "Aqsa", "initials": "A"}, {"family": "Poh", "given": "Bee Koon", "initials": "BK"}, {"family": "Del Pozo-Cruz", "given": "Borja", "initials": "B"}, {"family": "Chan", "given": "Cecilia H S", "initials": "CHS"}, {"family": "Nystr\u00f6m", "given": "Christine Delisle", "initials": "CD"}, {"family": "Koh", "given": "Denise", "initials": "D"}, {"family": "Webster", "given": "E Kipling", "initials": "EK"}, {"family": "Lubree", "given": "Himangi", "initials": "H"}, {"family": "Tang", "given": "Hong Kim", "initials": "HK"}, {"family": "Baddou", "given": "Issad", "initials": "I"}, {"family": "Del Pozo-Cruz", "given": "Jesus", "initials": "J"}, {"family": "Wong", "given": "Jyh Eiin", "initials": "JE"}, {"family": "Sultoni", "given": "Kuston", "initials": "K"}, {"family": "Nacher", "given": "Maria", "initials": "M"}, {"family": "L\u00f6f", "given": "Marie", "initials": "M"}, {"family": "Cui", "given": "Mingming", "initials": "M"}, {"family": "Hossain", "given": "Mohammad Sorowar", "initials": "MS"}, {"family": "Chathurangana", "given": "P W Prasad", "initials": "PWP"}, {"family": "Kand", "given": "Uddhavi", "initials": "U"}, {"family": "Wickramasinghe", "given": "V P Pujitha", "initials": "VPP"}, {"family": "Calleia", "given": "Rebecca", "initials": "R"}, {"family": "Ferdous", "given": "Shameema", "initials": "S"}, {"family": "Van Kim", "given": "Thanh", "initials": "T"}, {"family": "Wang", "given": "Xiaojuan", "initials": "X"}, {"family": "Draper", "given": "Catherine E", "initials": "CE"}], "type": "journal article", "published": "2021-05-17", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "940"}, "abstract": "The restrictions associated with the 2020 COVID-19 pandemic has resulted in changes to young children's daily routines and habits. The impact on their participation in movement behaviours (physical activity, sedentary screen time and sleep) is unknown. This international longitudinal study compared young children's movement behaviours before and during the COVID-19 pandemic.\r\n\r\nParents of children aged 3-5 years, from 14 countries (8 low- and middle-income countries, LMICs) completed surveys to assess changes in movement behaviours and how these changes were associated with the COVID-19 pandemic. Surveys were completed in the 12 months up to March 2020 and again between May and June 2020 (at the height of restrictions). Physical activity (PA), sedentary screen time (SST) and sleep were assessed via parent survey. At Time 2, COVID-19 factors including level of restriction, environmental conditions, and parental stress were measured. Compliance with the World Health Organizations (WHO) Global guidelines for PA (180 min/day [\u226560 min moderate- vigorous PA]), SST (\u22641 h/day) and sleep (10-13 h/day) for children under 5 years of age, was determined.\r\n\r\nNine hundred- forty-eight parents completed the survey at both time points. Children from LMICs were more likely to meet the PA (Adjusted Odds Ratio [AdjOR] = 2.0, 95%Confidence Interval [CI] 1.0,3.8) and SST (AdjOR = 2.2, 95%CI 1.2,3.9) guidelines than their high-income country (HIC) counterparts. Children who could go outside during COVID-19 were more likely to meet all WHO Global guidelines (AdjOR = 3.3, 95%CI 1.1,9.8) than those who were not. Children of parents with higher compared to lower stress were less likely to meet all three guidelines (AdjOR = 0.5, 95%CI 0.3,0.9).\r\n\r\nPA and SST levels of children from LMICs have been less impacted by COVID-19 than in HICs. Ensuring children can access an outdoor space, and supporting parents' mental health are important prerequisites for enabling pre-schoolers to practice healthy movement behaviours and meet the Global guidelines.", "doi": "10.1186/s12889-021-10852-3", "pmid": "34001086", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-10852-3"}], "notes": [], "created": "2021-05-20T14:51:42.291Z", "modified": "2021-07-14T08:56:13.805Z"}, {"entity": "publication", "iuid": "d83d23d7494d4c23a2587957eff51f2e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d83d23d7494d4c23a2587957eff51f2e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d83d23d7494d4c23a2587957eff51f2e"}}, "title": "Biomimetics provides lessons from nature for contemporary ways to improve human health.", "authors": [{"family": "Stenvinkel", "given": "Peter", "initials": "P"}, {"family": "Avesani", "given": "Carla M", "initials": "CM"}, {"family": "Gordon", "given": "Line J", "initials": "LJ"}, {"family": "Schalling", "given": "Martin", "initials": "M"}, {"family": "Shiels", "given": "Paul G", "initials": "PG"}], "type": "journal article", "published": "2021-05-17", "journal": {"title": "J Clin Transl Sci", "issn": "2059-8661", "volume": "5", "issue": "1", "pages": "e128", "issn-l": null}, "abstract": "Homo sapiens is currently living in serious disharmony with the rest of the natural world. For our species to survive, and for our well-being, we must gather knowledge from multiple perspectives and actively engage in studies of planetary health. The enormous diversity of species, one of the most striking aspects of life on our planet, provides a source of solutions that have been developed through evolution by natural selection by animals living in extreme environments. The food system is central to finding solutions; our current global eating patterns have a negative impact on human health, driven climate change and loss of biodiversity. We propose that the use of solutions derived from nature, an approach termed biomimetics, could mitigate the effects of a changing climate on planetary health as well as human health. For example, activation of the transcription factor Nrf2 may play a role in protecting animals living in extreme environments, or animals exposed to heat stress, pollution and pesticides. In order to meet these challenges, we call for the creation of novel interdisciplinary planetary health research teams.", "doi": "10.1017/cts.2021.790", "pmid": "34367673", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2059866121007901"}, {"db": "pmc", "key": "PMC8327543"}], "notes": [], "created": "2021-08-11T14:34:37.080Z", "modified": "2021-08-11T14:34:37.104Z"}, {"entity": "publication", "iuid": "8904e683c1844c42b5b8b5312843711d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8904e683c1844c42b5b8b5312843711d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8904e683c1844c42b5b8b5312843711d"}}, "title": "Antiviral Activity of Silver, Copper Oxide and Zinc Oxide Nanoparticle Coatings against SARS-CoV-2.", "authors": [{"family": "Merkl", "given": "Padryk", "initials": "P"}, {"family": "Long", "given": "Siwen", "initials": "S"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}, {"family": "Sotiriou", "given": "Georgios A", "initials": "GA"}], "type": "journal article", "published": "2021-05-17", "journal": {"title": "Nanomaterials (Basel)", "issn": "2079-4991", "issn-l": null, "volume": "11", "issue": "5", "pages": null}, "abstract": "SARS-CoV-2 is responsible for several million deaths to date globally, and both fomite transmission from surfaces as well as airborne transmission from aerosols may be largely responsible for the spread of the virus. Here, nanoparticle coatings of three antimicrobial materials (Ag, CuO and ZnO) are deposited on both solid flat surfaces as well as porous filter media, and their activity against SARS-CoV-2 viability is compared with a viral plaque assay. These nanocoatings are manufactured by aerosol nanoparticle self-assembly during their flame synthesis. Nanosilver particles as a coating exhibit the strongest antiviral activity of the three studied nanomaterials, while copper oxide exhibits moderate activity, and zinc oxide does not appear to significantly reduce the virus infectivity. Thus, nanosilver and copper oxide show potential as antiviral coatings on solid surfaces and on filter media to minimize transmission and super-spreading events while also providing critical information for the current and any future pandemic mitigation efforts.", "doi": "10.3390/nano11051312", "pmid": "34067553", "labels": {"Type: Journal article": null, "Funder: H2020": null, "Funder: VR": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "nano11051312"}], "notes": [], "created": "2021-06-04T11:20:05.272Z", "modified": "2021-08-25T14:33:10.797Z"}, {"entity": "publication", "iuid": "88dc506deffe4af0bf0684e37850a9a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/88dc506deffe4af0bf0684e37850a9a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/88dc506deffe4af0bf0684e37850a9a1"}}, "title": "Evaluation of SARS-CoV-2 rapid antigen diagnostic tests for saliva samples", "authors": [{"family": "Hagbom", "given": "Marie", "initials": "M"}, {"family": "Carmona-Vicente", "given": "Noelia", "initials": "N"}, {"family": "Sharma", "given": "Sumit", "initials": "S"}, {"family": "Olsson", "given": "Henrik", "initials": "H"}, {"family": "J\u00e4mtberg", "given": "Mikael", "initials": "M"}, {"family": "Nilsdotter-Augustinsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Sj\u00f6wall", "given": "Johanna", "initials": "J"}, {"family": "Nordgren", "given": "Johan", "initials": "J"}], "type": "posted-content", "published": "2021-05-16", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.05.14.21257100", "pmid": null, "labels": {"Type: Preprint": null, "Category: Serology": null}, "xrefs": [], "notes": [], "created": "2021-05-17T19:12:07.448Z", "modified": "2021-05-18T08:00:44.306Z"}, {"entity": "publication", "iuid": "a3d7ea4ae85740d18514f0d6cce89c17", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3d7ea4ae85740d18514f0d6cce89c17.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3d7ea4ae85740d18514f0d6cce89c17"}}, "title": "Worldwide Early Impact of COVID-19 on Dialysis Patients and Staff and Lessons Learned: A DOPPS Roundtable Discussion.", "authors": [{"family": "Robinson", "given": "Bruce M", "initials": "BM"}, {"family": "Guedes", "given": "Murilo", "initials": "M"}, {"family": "Alghonaim", "given": "Mohammed", "initials": "M"}, {"family": "Cases", "given": "Aleix", "initials": "A"}, {"family": "Dasgupta", "given": "Indranil", "initials": "I"}, {"family": "Gan", "given": "Liangying", "initials": "L"}, {"family": "Jacobson", "given": "Stefan H", "initials": "SH"}, {"family": "Kanjanabuch", "given": "Talerngsak", "initials": "T"}, {"family": "Kim", "given": "Yong-Lim", "initials": "YL"}, {"family": "Kleophas", "given": "Werner", "initials": "W"}, {"family": "Labriola", "given": "Laura", "initials": "L"}, {"family": "Perlman", "given": "Rachel L", "initials": "RL"}, {"family": "Reboldi", "given": "Gianpaolo", "initials": "G"}, {"family": "Srivatana", "given": "Vesh", "initials": "V"}, {"family": "Suri", "given": "Rita S", "initials": "RS"}, {"family": "Tsuruya", "given": "Kazuhiko", "initials": "K"}, {"family": "Torres", "given": "Pablo Urena", "initials": "PU"}, {"family": "Pisoni", "given": "Ronald L", "initials": "RL"}, {"family": "Pecoits-Filho", "given": "Roberto", "initials": "R"}], "type": "journal article", "published": "2021-05-14", "journal": {"title": "Kidney Med", "issn": "2590-0595", "volume": null, "issue": null, "issn-l": null}, "abstract": "As the worst global pandemic of the past century, COVID-19 has had a disproportionate effect on maintenance dialysis patients and their health care providers. At a virtual roundtable on 12 June 2020, DOPPS investigators from fifteen countries in Asia, Europe, and the Americas described and compared the effects of COVID-19 on dialysis care, with recent updates added. Most striking is the huge difference in risk to dialysis patients and staff across the world. Per-population cases and deaths among dialysis patients vary over 100-fold across participating countries, mirroring burden in the general population. International data indicate case fatality ratio remains at 10-30% among dialysis patients, confirming the gravity of infection, and that cases are much more common among in-center than home dialysis patients. This latter finding merits urgent study because in-center patients often have greater community exposure, and in-center transmission may be uncommon under optimal protocols. Greater telemedicine use is a welcome change here to stay, and our community needs to improve emergency planning and protect dialysis staff from the next pandemic. Finally, the pandemic's challenges have prompted widespread partnering and innovation in kidney care and research that must be sustained after this global health crisis.", "doi": "10.1016/j.xkme.2021.03.006", "pmid": "34007963", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2590-0595(21)00094-7"}, {"db": "pmc", "key": "PMC8120787"}], "notes": [], "created": "2021-05-20T14:41:36.932Z", "modified": "2021-05-21T17:15:11.990Z"}, {"entity": "publication", "iuid": "344e674e29bf4ea2a231789151621751", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/344e674e29bf4ea2a231789151621751.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/344e674e29bf4ea2a231789151621751"}}, "title": "Disease surveillance for the COVID-19 era: time for bold changes.", "authors": [{"family": "Morgan", "given": "Oliver W", "initials": "OW"}, {"family": "Aguilera", "given": "Ximena", "initials": "X"}, {"family": "Ammon", "given": "Andrea", "initials": "A"}, {"family": "Amuasi", "given": "John", "initials": "J"}, {"family": "Fall", "given": "Ibrahima Soc\u00e9", "initials": "IS"}, {"family": "Frieden", "given": "Tom", "initials": "T"}, {"family": "Heymann", "given": "David", "initials": "D"}, {"family": "Ihekweazu", "given": "Chikwe", "initials": "C"}, {"family": "Jeong", "given": "Eun-Kyeong", "initials": "EK"}, {"family": "Leung", "given": "Gabriel M", "initials": "GM"}, {"family": "Mahon", "given": "Barbara", "initials": "B"}, {"family": "Nkengasong", "given": "John", "initials": "J"}, {"family": "Qamar", "given": "Farah Naz", "initials": "FN"}, {"family": "Schuchat", "given": "Anne", "initials": "A"}, {"family": "Wieler", "given": "Lothar H", "initials": "LH"}, {"family": "Dowell", "given": "Scott F", "initials": "SF"}], "type": "journal article", "published": "2021-05-14", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": null, "issue": null, "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(21)01096-5", "pmid": "34000258", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)01096-5"}, {"db": "pmc", "key": "PMC8121493"}], "notes": [], "created": "2021-05-21T16:57:57.411Z", "modified": "2021-05-21T16:57:57.422Z"}, {"entity": "publication", "iuid": "7f250fa51c5b4cf3bb2120dd63e64434", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f250fa51c5b4cf3bb2120dd63e64434.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f250fa51c5b4cf3bb2120dd63e64434"}}, "title": "Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials.", "authors": [{"family": "Axfors", "given": "Cathrine", "initials": "C"}, {"family": "Schmitt", "given": "Andreas M", "initials": "AM", "orcid": "0000-0002-9568-8164", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e04ff63fee604c08bb913012e4645bf6.json"}}, {"family": "Janiaud", "given": "Perrine", "initials": "P"}, {"family": "Van't Hooft", "given": "Janneke", "initials": "J", "orcid": "0000-0001-5303-1503", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d0cd2d5d4ae4c88bf5b3307e32869a8.json"}}, {"family": "Abd-Elsalam", "given": "Sherief", "initials": "S", "orcid": "0000-0003-4366-2218", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fb051b677594bbca20b5637fc0420a9.json"}}, {"family": "Abdo", "given": "Ehab F", "initials": "EF", "orcid": "0000-0002-9805-3850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04cb35857c4b46829ebb73f25fad291a.json"}}, {"family": "Abella", "given": "Benjamin S", "initials": "BS", "orcid": "0000-0003-2521-0891", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7572ea9966aa4951afd5d2490960148e.json"}}, {"family": "Akram", "given": "Javed", "initials": "J"}, {"family": "Amaravadi", "given": "Ravi K", "initials": "RK"}, {"family": "Angus", "given": "Derek C", "initials": "DC"}, {"family": "Arabi", "given": "Yaseen M", "initials": "YM"}, {"family": "Azhar", "given": "Shehnoor", "initials": "S"}, {"family": "Baden", "given": "Lindsey R", "initials": "LR"}, {"family": "Baker", "given": "Arthur W", "initials": "AW", "orcid": "0000-0002-0914-0291", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51dd5ed5fb784143955e3c7e587b7014.json"}}, {"family": "Belkhir", "given": "Leila", "initials": "L"}, {"family": "Benfield", "given": "Thomas", "initials": "T", "orcid": "0000-0003-0698-9385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a335d1a321c46b2a0ba4f80dc3d93b4.json"}}, {"family": "Berrevoets", "given": "Marvin A H", "initials": "MAH"}, {"family": "Chen", "given": "Cheng-Pin", "initials": "CP", "orcid": "0000-0002-0629-9790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/773f850e035a47269048204713babe5f.json"}}, {"family": "Chen", "given": "Tsung-Chia", "initials": "TC", "orcid": "0000-0002-3461-5535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2df09990f13243b6a7d586e65808f9a5.json"}}, {"family": "Cheng", "given": "Shu-Hsing", "initials": "SH", "orcid": "0000-0002-6256-0527", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44efc129a6a54e9a85422a2c1122c047.json"}}, {"family": "Cheng", "given": "Chien-Yu", "initials": "CY"}, {"family": "Chung", "given": "Wei-Sheng", "initials": "WS", "orcid": "0000-0003-4240-5690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79973df7d6b94b529a779c7b3d1bc471.json"}}, {"family": "Cohen", "given": "Yehuda Z", "initials": "YZ", "orcid": "0000-0001-6987-1478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3839874cc0f4a91a69d0fb2fc15c35a.json"}}, {"family": "Cowan", "given": "Lisa N", "initials": "LN"}, {"family": "Dalgard", "given": "Olav", "initials": "O"}, {"family": "de Almeida E Val", "given": "Fernando F", "initials": "FF"}, {"family": "de Lacerda", "given": "Marcus V G", "initials": "MVG", "orcid": "0000-0003-3374-9985", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5df56fcaab5d4fbea3ee4a973b3ed44f.json"}}, {"family": "de Melo", "given": "Gisely C", "initials": "GC"}, {"family": "Derde", "given": "Lennie", "initials": "L", "orcid": "0000-0002-3577-5629", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cdd814a355e486a88cb134b060427bc.json"}}, {"family": "Dubee", "given": "Vincent", "initials": "V", "orcid": "0000-0002-9982-4741", "researcher": {"href": 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"given": "Ronghua", "initials": "R"}, {"family": "Jurado-Camacho", "given": "Felipe", "initials": "F"}, {"family": "Khan", "given": "Khalid S", "initials": "KS"}, {"family": "Kremsner", "given": "Peter G", "initials": "PG"}, {"family": "Kreuels", "given": "Benno", "initials": "B", "orcid": "0000-0003-2315-8954", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/752c98a06cbb43f9b5b8bf63127dd654.json"}}, {"family": "Kuo", "given": "Cheng-Yu", "initials": "CY"}, {"family": "Le", "given": "Thuy", "initials": "T", "orcid": "0000-0002-3393-6580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2380b23c0d1f423aa831d72279980706.json"}}, {"family": "Lin", "given": "Yi-Chun", "initials": "YC"}, {"family": "Lin", "given": "Wu-Pu", "initials": "WP", "orcid": "0000-0002-4206-7882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86d19e5169de4a139c6508eb7bd1e085.json"}}, {"family": "Lin", "given": "Tse-Hung", "initials": "TH"}, {"family": "Lyngbakken", "given": "Magnus Nakrem", "initials": "MN", "orcid": "0000-0002-5994-9304", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70c443e4d3674615bf090ed3b0d39e98.json"}}, {"family": "McArthur", "given": "Colin", "initials": "C"}, {"family": "McVerry", "given": "Bryan J", "initials": "BJ", "orcid": "0000-0002-1175-4874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/941d8c555b224fb18d897e9201d42f35.json"}}, {"family": "Meza-Meneses", "given": "Patricia", "initials": "P", "orcid": "0000-0002-3931-3114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be8220f4a58244838e2252f67c3ea28b.json"}}, {"family": "Monteiro", "given": "Wuelton M", "initials": "WM"}, {"family": "Morpeth", "given": "Susan C", "initials": "SC"}, {"family": "Mourad", "given": "Ahmad", "initials": "A", "orcid": "0000-0002-3149-597X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3323fc32cf4e44b2b677b838954f86aa.json"}}, {"family": "Mulligan", "given": "Mark J", "initials": "MJ"}, {"family": "Murthy", "given": "Srinivas", "initials": "S"}, {"family": "Naggie", "given": "Susanna", "initials": "S"}, {"family": "Narayanasamy", "given": "Shanti", "initials": "S", "orcid": "0000-0002-6667-2868", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53cc5ca9db8d49678370dbaad3d91ac0.json"}}, {"family": "Nichol", "given": "Alistair", "initials": "A"}, {"family": "Novack", "given": "Lewis A", "initials": "LA"}, {"family": "O'Brien", "given": "Sean M", "initials": "SM"}, {"family": "Okeke", "given": "Nwora Lance", "initials": "NL"}, {"family": "Perez", "given": "L\u00e9na", "initials": "L"}, {"family": "Perez-Padilla", "given": "Rogelio", "initials": "R"}, {"family": "Perrin", "given": "Laurent", "initials": "L", "orcid": "0000-0002-1916-6639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bdac388f14a404aa6a02e69083181fb.json"}}, {"family": "Remigio-Luna", "given": "Arantxa", "initials": "A"}, {"family": "Rivera-Martinez", "given": "Norma E", "initials": "NE", "orcid": "0000-0002-6716-1234", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0214c04c5d94f0082f9068398ab6e37.json"}}, {"family": "Rockhold", "given": "Frank W", "initials": "FW", "orcid": "0000-0003-3732-4765", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/409f57f9cdcd46f7bac6c309f50f6673.json"}}, {"family": "Rodriguez-Llamazares", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-7864-8953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76eb08936ea3405eb020251713f28c3d.json"}}, {"family": "Rolfe", "given": "Robert", "initials": "R"}, {"family": "Rosa", "given": "Rossana", "initials": "R"}, {"family": "R\u00f8sj\u00f8", "given": "Helge", "initials": "H"}, {"family": "Sampaio", "given": "Vanderson S", "initials": "VS", "orcid": "0000-0001-7307-8851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/934ee588c764416998481a7dbe4aad3e.json"}}, {"family": "Seto", "given": "Todd B", "initials": "TB"}, {"family": "Shahzad", "given": "Muhammad", "initials": "M"}, {"family": "Soliman", "given": "Shaimaa", "initials": "S"}, {"family": "Stout", "given": "Jason E", "initials": "JE", "orcid": "0000-0002-6698-8176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45ca2262503a439db34471f94f65aa11.json"}}, {"family": "Thirion-Romero", "given": "Ireri", "initials": "I"}, {"family": "Troxel", "given": "Andrea B", "initials": "AB"}, {"family": "Tseng", "given": "Ting-Yu", "initials": "TY"}, {"family": "Turner", "given": "Nicholas A", "initials": "NA", "orcid": "0000-0003-0650-4894", "researcher": {"href": 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"https://publications-covid19.scilifelab.se/researcher/f6d3264c064a4675bdbde7937711265c.json"}}, {"family": "Zhong", "given": "Wu", "initials": "W", "orcid": "0000-0002-0536-620X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8058cd239379403195b1cd7d9b5ca689.json"}}, {"family": "Moher", "given": "David", "initials": "D", "orcid": "0000-0003-2434-4206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/765e99136e2943c7a7f4ce4ed5848ff9.json"}}, {"family": "Goodman", "given": "Steven N", "initials": "SN"}, {"family": "Ioannidis", "given": "John P A", "initials": "JPA", "orcid": "0000-0003-3118-6859", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9844ea41bc554157a721820d7986a442.json"}}, {"family": "Hemkens", "given": "Lars G", "initials": "LG", "orcid": "0000-0002-3444-1432", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b2562d656a74e7d91427b55ca667784.json"}}], "type": "published erratum", "published": "2021-05-14", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "3001", "issn-l": "2041-1723"}, "abstract": null, "doi": "10.1038/s41467-021-23559-1", "pmid": "33990619", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8121133"}, {"db": "pii", "key": "10.1038/s41467-021-23559-1"}], "notes": [], "created": "2021-05-17T18:41:37.862Z", "modified": "2023-06-19T15:39:56.966Z"}, {"entity": "publication", "iuid": "26c86085b9c84f40a35b66cd590454f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26c86085b9c84f40a35b66cd590454f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26c86085b9c84f40a35b66cd590454f8"}}, "title": "Changes in Availability, Utilization, and Prices of Medicines and Protection Equipment for COVID-19 in an Urban Population of Northern Nigeria.", "authors": [{"family": "Haque", "given": "Mainul", "initials": "M"}, {"family": "Abubakar", "given": "Abdullahi Rabiu", "initials": "AR"}, {"family": "Ogunleye", "given": "Olayinka O", "initials": "OO"}, {"family": "Sani", "given": "Ibrahim Haruna", "initials": "IH"}, {"family": "Sefah", "given": "Israel", "initials": "I"}, {"family": "Kurdi", "given": "Amanj", "initials": "A"}, {"family": "Islam", "given": "Salequl", "initials": "S"}, {"family": "Godman", "given": "Brian", "initials": "B"}], "type": "journal article", "published": "2021-05-13", "journal": {"title": "J Res Pharm Pract", "issn": "2319-9644", "volume": "10", "issue": "1", "pages": "17-22", "issn-l": null}, "abstract": "Measures are ongoing to prevent the spread of COVID-19 and treat it with medicines and personal protective equipment (PPE). However, there has been considerable controversy surrounding treatments such as hydroxychloroquine with misinformation fuelling prices hikes and suicides. Shortages have also appreciably increased costs of PPE, potentially catastrophic among lower- and middle-income countries such as Nigeria with high copayment levels. Consequently, a need to investigate changes in availability, utilization, and prices of relevant medicines and PPE during the pandemic in Nigeria.\n\nExploratory study among community pharmacists with a survey tool comprising four sections including questions on changes in consumption, prices, and shortages of medicines and PPE from the beginning of March 2020 to the end of June 2020. In addition, suggestions from community pharmacists and co-authors on ways to reduce misinformation.\n\n30 out of 34 pharmacists participated giving a response rate of 88.2%. Significant increases were seen (3-fold or more increase) in the consumption of hydroxychloroquine (100%), vitamins/immune boosters (96.7%) and antibiotics (46.7%) as well as PPE (100%). Considerable price increases (50% increase or greater) also seen for antimalarials (96.7%), antibiotics (93.3%), vitamins/immune boosters (66.7%), and PPE (100%). Shortages are also seen for hydroxychloroquine and vitamins/immune boosters but most severe for PPE (80% of pharmacies).\n\nEncouraging to see increases in the utilization of vitamins/immune boosters and PPE. However, a considerable increase in the utilization and prices of antimicrobials is a concern that needs addressing including misinformation. Community pharmacists have a key role in providing evidence-based advice and helping moderate prices.", "doi": "10.4103/jrpp.JRPP_20_92", "pmid": "34295848", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "JRPP-10-17"}, {"db": "pmc", "key": "PMC8259594"}], "notes": [], "created": "2021-08-05T11:08:14.212Z", "modified": "2021-08-05T11:08:14.238Z"}, {"entity": "publication", "iuid": "8aba6dd2ad9e4c22af045650c75a91d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8aba6dd2ad9e4c22af045650c75a91d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8aba6dd2ad9e4c22af045650c75a91d7"}}, "title": "A Framework-Based Approach to Assessing Mental Health Impacts of the COVID-19 Pandemic on Children and Adolescents.", "authors": [{"family": "Lin", "given": "Ping-I", "initials": "PI"}, {"family": "Srivastava", "given": "Gautam", "initials": "G"}, {"family": "Beckman", "given": "Linda", "initials": "L"}, {"family": "Kim", "given": "Yunhwan", "initials": "Y"}, {"family": "Hallerb\u00e4ck", "given": "Maria", "initials": "M"}, {"family": "Barzman", "given": "Drew", "initials": "D"}, {"family": "Sorter", "given": "Michael", "initials": "M"}, {"family": "Eapen", "given": "Valsamma", "initials": "V"}], "type": "journal article", "published": "2021-05-13", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "issue": null, "pages": "655481", "issn-l": "1664-0640"}, "abstract": "The COVID-19 pandemic has yielded extensive impacts globally in the year of 2020. Although the mental health of children and adolescents may be particularly susceptible to stressors stemming from the pandemic and anti-contagion policies, most ongoing efforts are geared toward curbing the viral spread. In the current perspective, we have identified four domains of factors corresponding to an ecological framework that may directly or indirectly influence the mental health of children and adolescents during the pandemic. The evidence suggests that anti-contagion policies might trigger cascades that impact the mental health of children and their families through multiple different sectors that used to form a safety net for youths. Additionally, children with neuropsychiatric disorders could experience exacerbated symptoms during the pandemic. Furthermore, the risk of domestic violence has surged during the pandemic, which further compounds the imminent mental health crisis. A mental health pandemic could be inevitable if no proactive prevention strategies were in place. Therefore, we recommend understanding each individual mental health risk pathway via the ecological framework in order to develop integrative prevention and intervention strategies.", "doi": "10.3389/fpsyt.2021.655481", "pmid": "34054613", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8155579"}], "notes": [], "created": "2021-06-04T11:29:09.017Z", "modified": "2021-06-04T11:29:24.098Z"}, {"entity": "publication", "iuid": "56d26eeb5c9c4efc996cfcb0c0f592be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56d26eeb5c9c4efc996cfcb0c0f592be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56d26eeb5c9c4efc996cfcb0c0f592be"}}, "title": "Prevention of COVID-19: Preventive Strategies for General Population, Healthcare Setting, and Various Professions.", "authors": [{"family": "Moossavi", "given": "Shirin", "initials": "S"}, {"family": "Fehr", "given": "Kelsey", "initials": "K"}, {"family": "Maleki", "given": "Hassan", "initials": "H"}, {"family": "Seyedpour", "given": "Simin", "initials": "S"}, {"family": "Keshavarz-Fathi", "given": "Mahdis", "initials": "M"}, {"family": "Tabasi", "given": "Farhad", "initials": "F"}, {"family": "Heravi", "given": "Mehrdad", "initials": "M"}, {"family": "Sharifian", "given": "Rayka", "initials": "R"}, {"family": "Shafiei", "given": "Golnaz", "initials": "G"}, {"family": "Badihian", "given": "Negin", "initials": "N"}, {"family": "Kelishadi", "given": "Roya", "initials": "R"}, {"family": "Nematollahi", "given": "Shahrzad", "initials": "S"}, {"family": "Almasi", "given": "Majid", "initials": "M"}, {"family": "Popescu", "given": "Saskia", "initials": "S"}, {"family": "Keshavarz-Fathi", "given": "Mahsa", "initials": "M"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}], "type": "journal article", "published": "2021-05-12", "journal": {"title": "Adv Exp Med Biol", "issn": "0065-2598", "volume": "1318", "issue": null, "pages": "575-604", "issn-l": null}, "abstract": "The disease 2019 (COVID-19) made a public health emergency in early 2020. Despite attempts for the development of therapeutic modalities, there is no effective treatment yet. Therefore, preventive measures in various settings could help reduce the burden of disease. In this chapter, the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19, non-pharmaceutical approaches at individual and population level, chemoprevention, immunoprevention, preventive measures in different healthcare settings and other professions, special considerations in high-risk groups, and the role of organizations to hamper the psychosocial effects will be discussed.", "doi": "10.1007/978-3-030-63761-3_32", "pmid": "33973200", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:54:33.345Z", "modified": "2021-05-17T18:54:33.367Z"}, {"entity": "publication", "iuid": "78f4a96977f74a7ab78fd1202cd37856", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/78f4a96977f74a7ab78fd1202cd37856.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/78f4a96977f74a7ab78fd1202cd37856"}}, "title": "Numbers don't speak for themselves: strategies of using numbers in public policy discourse.", "authors": [{"family": "Jablonka", "given": "Eva", "initials": "E", "orcid": "0000-0003-1019-792X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/99fa33b32e274c75b04539c706400382.json"}}, {"family": "Bergsten", "given": "Christer", "initials": "C", "orcid": "0000-0002-3681-3535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f9cbb818e524b0f84a84f797d6e611a.json"}}], "type": "journal article", "published": "2021-05-12", "journal": {"title": "Educ Stud Math", "issn": "1573-0816", "pages": "1-18", "issn-l": null}, "abstract": "In mathematics education, there is general agreement regarding the significance of mathematical literacy (also quantitative literacy or numeracy) for informed citizenship, which often requires evaluating the use of numbers in public policy discourse. We hold that such an evaluation must accommodate the necessarily fragile relation between the information that numbers are taken to carry and the policy decisions they are meant to support. In doing so, attention needs to be paid to differences in how that relation is formed. With this in mind, we investigated a public discourse that heavily relied on numbers in the context of introducing, maintaining, and easing the rules and regulations directed to contain the spread of the virus SARS-CoV-2 during the first epidemic wave of COVID-19 in Germany with its peak in early April 2020. We used a public-service broadcasting outlet as data. Our theoretical stance is affiliated with post-structuralist discourse theory. As an outcome, we identified four major related strategies of using numbers, which we named rationalisation, contrast, association and recharging. In our view explicit attention to these strategies as well as identifying new ones can aid the task of furthering critical mathematical literacy.", "doi": "10.1007/s10649-021-10059-8", "pmid": "34934230", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10059"}, {"db": "pmc", "key": "PMC8113797"}], "notes": [], "created": "2022-01-03T15:31:26.383Z", "modified": "2022-01-03T15:31:26.492Z"}, {"entity": "publication", "iuid": "a8681cf4f3de46409df72b9d8c08063f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8681cf4f3de46409df72b9d8c08063f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8681cf4f3de46409df72b9d8c08063f"}}, "title": "Coronavirus: Pure Infectious Disease or Genetic Predisposition.", "authors": [{"family": "Darbeheshti", "given": "Farzaneh", "initials": "F"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Bashashati", "given": "Mohammad", "initials": "M"}, {"family": "Ghavami", "given": "Saeid", "initials": "S"}, {"family": "Shahkarami", "given": "Sepideh", "initials": "S"}, {"family": "Zoghi", "given": "Samaneh", "initials": "S"}, {"family": "Gupta", "given": "Sudhir", "initials": "S"}, {"family": "Orange", "given": "Jordan S", "initials": "JS"}, {"family": "Ochs", "given": "Hans D", "initials": "HD"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}], "type": "journal article", "published": "2021-05-12", "journal": {"title": "Adv Exp Med Biol", "issn": "0065-2598", "volume": "1318", "issue": null, "pages": "91-107", "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes novel coronavirus disease (COVID-19), is the seventh pathogenic coronavirus recently discovered in December 2019 in Wuhan, China. To date, our knowledge about its effect on the human host remains limited. It is well known that host genetic factors account for the individual differences in the susceptibility to infectious diseases. The genetic susceptibility factors to COVID-19 and its severity are associated with several unanswered questions. However, the experience gained from an earlier strain of coronavirus, SARS-CoV-1, which shows 78% genetic similarity to SARS-CoV-2 and uses the same receptor to bind to host cells, could provide some clues. It, therefore, seems possible to assemble new evidence in order to solve a potential genetic predisposition puzzle for COVID-19. In this chapter, the puzzle pieces, including virus entry receptors, immune response, and inflammation-related genes, as well as the probable genetic predisposition models to COVID-19, are discussed.", "doi": "10.1007/978-3-030-63761-3_6", "pmid": "33973174", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:55:51.197Z", "modified": "2021-05-17T18:55:51.207Z"}, {"entity": "publication", "iuid": "5650033701204a63a0f7f17812cdf653", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5650033701204a63a0f7f17812cdf653.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5650033701204a63a0f7f17812cdf653"}}, "title": "Combined Cardiac Risk Factors Predict COVID-19 Related Mortality and the Need for Mechanical Ventilation in Coptic Clergy.", "authors": [{"family": "Henein", "given": "Michael Y", "initials": "MY"}, {"family": "Byty\u00e7i", "given": "Ibadete", "initials": "I"}, {"family": "Nicoll", "given": "Rachel", "initials": "R"}, {"family": "Shenouda", "given": "Rafik", "initials": "R"}, {"family": "Ayad", "given": "Sherif", "initials": "S"}, {"family": "Cameli", "given": "Matteo", "initials": "M"}, {"family": "Vancheri", "given": "Federico", "initials": "F"}], "type": "journal article", "published": "2021-05-12", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "10", "issue": "10", "issn-l": "2077-0383"}, "abstract": "The clinical adverse events of COVID-19 among clergy worldwide have been found to be higher than among ordinary communities, probably because of the nature of their work. The aim of this study was to assess the impact of cardiac risk factors on COVID-19-related mortality and the need for mechanical ventilation in Coptic clergy.\n\nOf 1570 Coptic clergy participating in the COVID-19-Clergy study, serving in Egypt, USA and Europe, 213 had the infection and were included in this analysis. Based on the presence of systemic arterial hypertension (AH), participants were divided into two groups: Group-I, clergy with AH ( n = 77) and Group-II, without AH (n = 136). Participants' demographic indices, cardiovascular risk factors, COVID-19 management details and related mortality were assessed.\n\nClergy with AH were older ( p < 0.001), more obese (p = 0.04), had frequent type 2 diabetes (DM) (p = 0.001), dyslipidemia (p = 0.001) and coronary heart disease (CHD) (p = 0.04) compared to those without AH. COVID-19 treatment at home, hospital or in intensive care did not differ between the patient groups (p > 0.05 for all). Clergy serving in Northern and Southern Egypt had a higher mortality rate compared to those from Europe and the USA combined (5.22%, 6.38%, 0%; p = 0.001). The impact of AH on mortality was significant only in Southern Egypt (10% vs. 3.7%; p = 0.01) but not in Northern Egypt (4.88% vs. 5.81%; p = 0.43). In multivariate analysis, CHD OR 1.607 ((0.982 to 3.051); p = 0.02) and obesity, OR 3.403 ((1.902 to 4.694); p = 0.04) predicted COVID-19 related mortality. A model combining cardiac risk factors (systolic blood pressure (SBP) \u2265 160 mmHg, DM, obesity and history of CHD) was the most powerful independent predictor of COVID-19-related mortality, OR 3.991 ((1.919 to 6.844); p = 0.002). Almost the same model also proved the best independent multivariate predictor of mechanical ventilation OR 1.501 ((0.809 to 6.108); p = 0.001).\n\nIn Coptic clergy, the cumulative impact of risk factors was the most powerful predictor of mortality and the need for mechanical ventilation.", "doi": "10.3390/jcm10102066", "pmid": "34065902", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jcm10102066"}], "notes": [], "created": "2021-06-04T11:23:13.799Z", "modified": "2021-06-04T11:23:36.205Z"}, {"entity": "publication", "iuid": "b9123a86798d42579531d0a65f4020b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9123a86798d42579531d0a65f4020b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9123a86798d42579531d0a65f4020b2"}}, "title": "COVID-19 in Patients with Cancer.", "authors": [{"family": "Nowroozi", "given": "Ali", "initials": "A"}, {"family": "Razi", "given": "Sepideh", "initials": "S"}, {"family": "Sahu", "given": "Kamal Kant", "initials": "KK"}, {"family": "Grizzi", "given": "Fabio", "initials": "F"}, {"family": "Arends", "given": "Jann", "initials": "J"}, {"family": "Keshavarz-Fathi", "given": "Mahsa", "initials": "M"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}], "type": "journal article", "published": "2021-05-12", "journal": {"title": "Adv Exp Med Biol", "issn": "0065-2598", "volume": "1318", "issue": null, "pages": "315-331", "issn-l": null}, "abstract": "With more than 5 million cases and 333,212 deaths, COVID-19 (or SARS-CoV-2) continues to spread. General symptoms of this disease are similar to that of many other viral respiratory diseases, including fever, cough, dyspnea, and fatigue, with a chance of progression to more severe complications. However, the virus does not affect all people equally, and cases with comorbidities such as malignancies, cardiovascular diseases, respiratory diseases, and kidney diseases are at higher risk of developing severe events, including requiring intensive ventilation, intensive care unit (ICU) admission, and death. Patients with cancer are more likely to be infected with COVID-19, which is possibly due to their immunological dysfunction or frequent clinic visits. Also, there is a higher chance that these patients experience severe events because of the medication they receive. In this chapter, we will review the main clinical manifestations of COVID-19 in patients with cancer. Recommendations and challenges for managing resources, organizing cancer centers, treatment of COVID-19-infected cancer patients, and performing cancer research during this pandemic will also be discussed.", "doi": "10.1007/978-3-030-63761-3_18", "pmid": "33973186", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:55:05.544Z", "modified": "2021-05-17T18:55:05.556Z"}, {"entity": "publication", "iuid": "a4272f9b05514336a607b145e6c4528a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a4272f9b05514336a607b145e6c4528a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a4272f9b05514336a607b145e6c4528a"}}, "title": "Beyond brick and mortar: staying connected in post-pandemic blended learning environments.", "authors": [{"family": "McGrath", "given": "Cormac", "initials": "C"}, {"family": "Palmgren", "given": "Per J", "initials": "PJ"}, {"family": "Liljedahl", "given": "Matilda", "initials": "M"}], "type": "journal article", "published": "2021-05-12", "journal": {"title": "Med Educ", "issn": "1365-2923", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "These are certainly unprecedented times and the ongoing Covid-19 pandemic has turned many ideas about teaching and learning in medical education on their head. Who would have thought that, overnight, brick and mortar universities would be providing education solely through digital means? This form of radical change comes along perhaps once in a lifetime, and currently we have not seen the full fallout, or the potential benefits from the sudden and dramatic shift in medical education. More than a year later, we still find ourselves telecommuting in front of our screens; teaching, supervising, and assessing.", "doi": "10.1111/medu.14546", "pmid": "33977575", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:47:19.209Z", "modified": "2022-11-22T05:47:36.508Z"}, {"entity": "publication", "iuid": "6bed9e4cb4c945d8b93a6c6339fd8fa8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6bed9e4cb4c945d8b93a6c6339fd8fa8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6bed9e4cb4c945d8b93a6c6339fd8fa8"}}, "title": "Use of repurposed and adjuvant drugs in hospital patients with covid-19: multinational network cohort study.", "authors": [{"family": "Prats-Uribe", "given": "Albert", "initials": "A"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Lai", "given": "Lana Yin Hui", "initials": "LYH"}, {"family": "Ahmed", "given": "Waheed-Ul-Rahman", "initials": "WU"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Carter", "given": "William", "initials": "W"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "Dawoud", "given": "Dalia", "initials": "D"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Jonnagaddala", "given": "Jitendra", "initials": "J"}, {"family": "Mehta", "given": "Paras P", "initials": "PP"}, {"family": "Gong", "given": "Mengchun", "initials": "M"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Recalde", "given": "Martina", "initials": "M"}, {"family": "Roel", "given": "Elena", "initials": "E"}, {"family": "Shah", "given": "Karishma", "initials": "K"}, {"family": "Shah", "given": "Nigam H", "initials": "NH"}, {"family": "Schilling", "given": "Lisa M", "initials": "LM"}, {"family": "Subbian", "given": "Vignesh", "initials": "V"}, {"family": "Vizcaya", "given": "David", "initials": "D"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhang", "given": "Ying", "initials": "Y"}, {"family": "Zhu", "given": "Hong", "initials": "H"}, {"family": "Liu", "given": "Li", "initials": "L"}, {"family": "Cho", "given": "Jaehyeong", "initials": "J"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Lane", "given": "Jennifer Ce", "initials": "JC"}, {"family": "Burn", "given": "Edward", "initials": "E"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Ryan", "given": "Patrick B", "initials": "PB", "orcid": "0000-0002-9727-2138", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7f5f6d8b6bb4d85b1430cda6aea55b8.json"}}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "373", "issue": null, "pages": "n1038", "issn-l": null}, "abstract": "To investigate the use of repurposed and adjuvant drugs in patients admitted to hospital with covid-19 across three continents.\n\nMultinational network cohort study.\n\nHospital electronic health records from the United States, Spain, and China, and nationwide claims data from South Korea.\n\n303 264 patients admitted to hospital with covid-19 from January 2020 to December 2020.\n\nPrescriptions or dispensations of any drug on or 30 days after the date of hospital admission for covid-19.\n\nOf the 303 264 patients included, 290 131 were from the US, 7599 from South Korea, 5230 from Spain, and 304 from China. 3455 drugs were identified. Common repurposed drugs were hydroxychloroquine (used in from <5 (<2%) patients in China to 2165 (85.1%) in Spain), azithromycin (from 15 (4.9%) in China to 1473 (57.9%) in Spain), combined lopinavir and ritonavir (from 156 (<2%) in the VA-OMOP US to 2,652 (34.9%) in South Korea and 1285 (50.5%) in Spain), and umifenovir (0% in the US, South Korea, and Spain and 238 (78.3%) in China). Use of adjunctive drugs varied greatly, with the five most used treatments being enoxaparin, fluoroquinolones, ceftriaxone, vitamin D, and corticosteroids. Hydroxychloroquine use increased rapidly from March to April 2020 but declined steeply in May to June and remained low for the rest of the year. The use of dexamethasone and corticosteroids increased steadily during 2020.\n\nMultiple drugs were used in the first few months of the covid-19 pandemic, with substantial geographical and temporal variation. Hydroxychloroquine, azithromycin, lopinavir-ritonavir, and umifenovir (in China only) were the most prescribed repurposed drugs. Antithrombotics, antibiotics, H2 receptor antagonists, and corticosteroids were often used as adjunctive treatments. Research is needed on the comparative risk and benefit of these treatments in the management of covid-19.", "doi": "10.1136/bmj.n1038", "pmid": "33975825", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC8111167"}], "notes": [], "created": "2021-05-17T18:47:58.975Z", "modified": "2023-06-19T15:36:24.527Z"}, {"entity": "publication", "iuid": "29339962371649a685dbe773e103b82d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/29339962371649a685dbe773e103b82d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/29339962371649a685dbe773e103b82d"}}, "title": "Transformation of primary care during the COVID-19 pandemic: experiences of healthcare professionals in eight European countries.", "authors": [{"family": "Wanat", "given": "Marta", "initials": "M"}, {"family": "Hoste", "given": "Melanie", "initials": "M"}, {"family": "Gobat", "given": "Nina", "initials": "N"}, {"family": "Anastasaki", "given": "Marilena", "initials": "M"}, {"family": "Boehmer", "given": "Femke", "initials": "F"}, {"family": "Chlabicz", "given": "Slawomir", "initials": "S"}, {"family": "Colliers", "given": "Annelies", "initials": "A"}, {"family": "Farrell", "given": "Karen", "initials": "K"}, {"family": "Karkana", "given": "Maria-Nefeli", "initials": "MN"}, {"family": "Kinsman", "given": "John", "initials": "J"}, {"family": "Lionis", "given": "Christos", "initials": "C"}, {"family": "Marcinowicz", "given": "Ludmila", "initials": "L"}, {"family": "Reinhardt", "given": "Katrin", "initials": "K"}, {"family": "Skoglund", "given": "Ingmarie", "initials": "I"}, {"family": "Sundvall", "given": "P\u00e4r-Daniel", "initials": "PD"}, {"family": "Vellinga", "given": "Akke", "initials": "A"}, {"family": "Verheij", "given": "Theo", "initials": "T"}, {"family": "Goossens", "given": "Herman", "initials": "H"}, {"family": "Butler", "given": "Christopher", "initials": "C"}, {"family": "van der Velden", "given": "Alike", "initials": "A"}, {"family": "Anthierens", "given": "Sibyl", "initials": "S"}, {"family": "Tonkin-Crine", "given": "Sarah", "initials": "S"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Br J Gen Pract", "issn": "1478-5242", "volume": null, "issue": null, "issn-l": null}, "abstract": "Primary care has a crucial role in responding to the COVID-19 pandemic as the first point of patient care and gatekeeper to secondary care. Qualitative studies exploring the experiences of healthcare professionals during the COVID-19 pandemic have mainly focused on secondary care.\n\nTo understand the experiences of European PCPs working during the first peak of the COVID-19 pandemic.\n\nAn exploratory qualitative study, using semi-structured interviews in primary care in England, Belgium, the Netherlands, Ireland, Germany, Poland, Greece and Sweden, between April and July 2020.\n\nInterviews were audio recorded, transcribed and analysed using a combination of inductive and deductive thematic analysis techniques.\n\nEighty interviews were conducted with PCPs. PCPs had to make their own decisions on how to rapidly transform services in relation to COVID-19 and non-COVID-19 care. Despite being overwhelmed with guidance, they often lacked access to practical training. Consequently, PCPs turned to their colleagues for moral support and information to try to quickly adjust to new ways of working, including remote care, and deal with uncertainty.\n\nPCPs rapidly transformed primary care delivery despite a number of challenges. Representation of primary care at policy level and engagement with local primary care champions will facilitate easy and coordinated access to practical information on how to adapt services, ongoing training and access to appropriate mental health support services for PCPs. Preservation of autonomy and responsiveness of primary care are critical to preserve the ability for rapid transformation in any future crisis of care delivery.", "doi": "10.3399/BJGP.2020.1112", "pmid": "33979303", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "BJGP.2020.1112"}], "notes": [], "created": "2021-05-17T18:43:33.883Z", "modified": "2021-05-21T17:01:41.572Z"}, {"entity": "publication", "iuid": "e215aad9f53e4b84850559d85c40ea41", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e215aad9f53e4b84850559d85c40ea41.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e215aad9f53e4b84850559d85c40ea41"}}, "title": "The perfect storm: Disruptions to institutional delivery care arising from the COVID-19 pandemic in Nepal.", "authors": [{"family": "Ashish", "given": "K C", "initials": "KC"}, {"family": "Peterson", "given": "Stefan Swartling", "initials": "SS"}, {"family": "Gurung", "given": "Rejina", "initials": "R"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A"}, {"family": "Gautam", "given": "Jageshwar", "initials": "J"}, {"family": "Malla", "given": "Honey", "initials": "H"}, {"family": "Paudel", "given": "Punya", "initials": "P"}, {"family": "Bhattarai", "given": "Kumari", "initials": "K"}, {"family": "Joshi", "given": "Nisha", "initials": "N"}, {"family": "Tinkari", "given": "Bhim Singh", "initials": "BS"}, {"family": "Adhikari", "given": "Shree", "initials": "S"}, {"family": "Shrestha", "given": "Durgalaxmi", "initials": "D"}, {"family": "Ghimire", "given": "Binda", "initials": "B"}, {"family": "Sharma", "given": "Seema", "initials": "S"}, {"family": "Khanal", "given": "Laxmi", "initials": "L"}, {"family": "Shrestha", "given": "Sunil", "initials": "S"}, {"family": "Graham", "given": "Wendy Jane", "initials": "WJ"}, {"family": "Kinney", "given": "Mary", "initials": "M"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "J Glob Health", "issn": "2047-2986", "volume": "11", "issue": null, "pages": "05010", "issn-l": "2047-2978"}, "abstract": "The COVID-19 pandemic has led to system-wide disruption of health services globally. We assessed the effect of the pandemic on the disruption of institutional delivery care in Nepal.\n\nWe conducted a prospective cohort study among 52 356 women in nine hospitals to assess the disruption of institutional delivery care during the pandemic (comparing March to August in 2019 with the same months in 2020). We also conducted a nested follow up cohort study with 2022 women during the pandemic to assess their provision and experience of respectful care. We used linear regression models to assess the association between provision and experience of care with volume of hospital births and women's residence in a COVID-19 hotspot area.\n\nThe mean institutional births during the pandemic across the nine hospitals was 24 563, an average decrease of 11.6% ( P < 0.0001) in comparison to the same time-period in 2019. The institutional birth in high-medium volume hospitals declined on average by 20.8% (P < 0.0001) during the pandemic, whereas in low-volume hospital institutional birth increased on average by 7.9% (P = 0.001). Maternity services halted for a mean of 4.3 days during the pandemic and there was a redeployment staff to COVID-19 dedicated care. Respectful provision of care was better in hospitals with low-volume birth (\u03b2 = 0.446, P < 0.0001) in comparison to high-medium-volume hospitals. There was a positive association between women's residence in a COVID-19 hotspot area and respectful experience of care (\u03b2 = 0.076, P = 0.001).\n\nThe COVID-19 pandemic has had differential effects on maternity services with changes varying by the volume of births per hospital with smaller volume facilities doing better. More research is needed to investigate the effects of the pandemic on where women give birth and their provision and experience of respectful maternity care to inform a \"building-back-better\" approach in post-pandemic period.", "doi": "10.7189/jogh.11.05010", "pmid": "34055329", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "jogh-11-05010"}, {"db": "pmc", "key": "PMC8141327"}], "notes": [], "created": "2021-06-04T11:28:42.299Z", "modified": "2021-06-04T11:28:42.309Z"}, {"entity": "publication", "iuid": "40cf5150085a4046a75dc1f9fe386a62", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/40cf5150085a4046a75dc1f9fe386a62.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/40cf5150085a4046a75dc1f9fe386a62"}}, "title": "Social distancing during the COVID-19 pandemic and health-related quality of life among esophageal cancer survivors.", "authors": [{"family": "Schandl", "given": "Anna", "initials": "A"}, {"family": "M\u00e4lberg", "given": "Kalle", "initials": "K"}, {"family": "Johar", "given": "Asif", "initials": "A"}, {"family": "Lagergren", "given": "Pernilla", "initials": "P"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Acta Oncol", "issn": "1651-226X", "volume": null, "issue": null, "pages": "1-8", "issn-l": null}, "abstract": "The purpose was to investigate whether social distancing during the COVID-19 pandemic reduced health-related quality of life (HRQL) in esophageal cancer patients and if so, to identify factors related to the HRQL changes.\n\nA prospective Swedish nationwide study of patients who undergone surgery for esophageal cancer between 2013 and 2019. Telephone interviews were conducted 5 weeks and 13 weeks after the introduction of social distancing recommendations. The participants responded to a few scales and items from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30. Regression models adjusted for potential confounders were used to examine mean score differences (MSD) with 95% confidence intervals (CI) between compliance with the recommendations and HRQL.\n\nIn total, 134 individuals participated in the study. At 5 weeks, a reduction in role function was seen for individuals who fully (MSD -8, 95% CI: -16 to 0) and to a large extent (MSD -19, 95% CI: -26 to -12) complied with the recommendations. Less fatigue (MSD 9, 95% CI: 3-15) was also detected for this group. Being female, elderly, having comorbidities, living in a region with higher COVID-19 incidence, living in a villa, and being considered as an at-risk person were related to changes in role function. At 13 weeks, reductions in role function continued for those who fully complied with the recommendations (MSD -10, 95% CI: -19 to -1), but the risk variables were of less importance. Improvements in fatigue were no longer detected. Global quality of life, emotional function, or insomnia remained stable over time.\n\nThis study indicates that individuals who undergone surgery for esophageal cancer and fully or to a large extent complied with the recommendations experienced reductions in role function, but not in global quality of life or emotional function, during the COVID-19 pandemic.", "doi": "10.1080/0284186X.2021.1921260", "pmid": "33974501", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:50:05.413Z", "modified": "2021-05-17T18:50:05.423Z"}, {"entity": "publication", "iuid": "762b430a5e3b4c3d809a370ec4193981", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/762b430a5e3b4c3d809a370ec4193981.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/762b430a5e3b4c3d809a370ec4193981"}}, "title": "Post-outbreak serological screening for SARS-CoV-2 infection in healthcare workers at a Swedish University Hospital.", "authors": [{"family": "Strand", "given": "Rasmus", "initials": "R"}, {"family": "Fernstr\u00f6m", "given": "Nils", "initials": "N"}, {"family": "Holmberg", "given": "Anna", "initials": "A"}, {"family": "De Marinis", "given": "Yang", "initials": "Y"}, {"family": "Fraenkel", "given": "Carl-Johan", "initials": "C"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": null, "issue": null, "pages": "1-6"}, "abstract": "Nosocomial outbreaks of coronavirus disease 2019 (COVID-19) can have devastating consequences from both a resource cost and patient healthcare perspective. Relying on reverse transcription-polymerase chain reaction (RT-PCR) for identifying infected individuals may result in missed cases. Screening for antibodies after an outbreak can help to find missed cases and better illuminate routes of transmission.\r\n\r\nIn this study, we present the results of a serological screening of the healthcare workers (HCWs) on a ward for infectious diseases in Sweden with a point-of-care antibody test 8 weeks after an outbreak of COVID-19. In all, 107/123 (87%) of HCWs who were tested with RT-PCR in the outbreak investigation participated in this study on seroprevalence. Participants were also asked to fill out a questionnaire entailing epidemiological data. The cohort was stratified by RT-PCR result and the resulting groups were compared to each other.\r\n\r\nSix (8%) HCWs who were tested RT-PCR negative during the outbreak investigation had developed specific IgG antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These HCWs had all worked shifts with colleagues who later were tested RT-PCR positive during the outbreak.\r\n\r\nOur results indicate that a serological follow-up screening after an outbreak may be used as a complement to virus detection in an outbreak situation. However, immunoglobulin (Ig) G-detection should also be performed at the start of an outbreak, to facilitate interpretation of the results.", "doi": "10.1080/23744235.2021.1925739", "pmid": "33974498", "labels": {"Type: Journal article": null, "Category: Serology": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:51:24.712Z", "modified": "2021-06-18T08:53:08.301Z"}, {"entity": "publication", "iuid": "930d2a63267f4a5babddd655671ec80b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/930d2a63267f4a5babddd655671ec80b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/930d2a63267f4a5babddd655671ec80b"}}, "title": "Nutritional management of individuals with obesity and COVID-19: ESPEN expert statements and practical guidance.", "authors": [{"family": "Barazzoni", "given": "Rocco", "initials": "R"}, {"family": "Bischoff", "given": "Stephan C", "initials": "SC"}, {"family": "Busetto", "given": "Luca", "initials": "L"}, {"family": "Cederholm", "given": "Tommy", "initials": "T"}, {"family": "Chourdakis", "given": "Michael", "initials": "M"}, {"family": "Cuerda", "given": "Cristina", "initials": "C"}, {"family": "Delzenne", "given": "Nathalie", "initials": "N"}, {"family": "Genton", "given": "Laurence", "initials": "L"}, {"family": "Schneider", "given": "Stephane", "initials": "S"}, {"family": "Singer", "given": "Pierre", "initials": "P"}, {"family": "Boirie", "given": "Yves", "initials": "Y"}, {"family": "endorsed by the ESPEN Council", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Clin Nutr", "issn": "1532-1983", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemics has created unprecedented challenges and threats to patients and healthcare systems worldwide. Acute respiratory complications that require intensive care unit (ICU) management are a major cause of morbidity and mortality in COVID-19 patients. Among other important risk factors for severe COVID-19 outcomes, obesity has emerged along with undernutrition-malnutrition as a strong predictor of disease risk and severity. Obesity-related excessive body fat may lead to respiratory, metabolic and immune derangements potentially favoring the onset of COVID-19 complications. In addition, patients with obesity may be at risk for loss of skeletal muscle mass, reflecting a state of hidden malnutrition with a strong negative health impact in all clinical settings. Also importantly, obesity is commonly associated with micronutrient deficiencies that directly influence immune function and infection risk. Finally, the pandemic-related lockdown, deleterious lifestyle changes and other numerous psychosocial consequences may worsen eating behaviors, sedentarity, body weight regulation, ultimately leading to further increments of obesity-associated metabolic complications with loss of skeletal muscle mass and higher non-communicable disease risk. Therefore, prevention, diagnosis and treatment of malnutrition and micronutrient deficiencies should be routinely included in the management of COVID-19 patients in the presence of obesity; lockdown-induced health risks should also be specifically monitored and prevented in this population. In the current document, the European Society for Clinical Nutrition and Metabolism (ESPEN) aims at providing clinical practice guidance for nutritional management of COVID-19 patients with obesity in various clinical settings.", "doi": "10.1016/j.clnu.2021.05.006", "pmid": "34140163", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0261-5614(21)00248-X"}, {"db": "pmc", "key": "PMC8110326"}], "notes": [], "created": "2021-06-28T18:30:11.127Z", "modified": "2021-06-28T18:30:42.013Z"}, {"entity": "publication", "iuid": "3a2fb90fbc5c49049f3760352f9c6421", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a2fb90fbc5c49049f3760352f9c6421.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a2fb90fbc5c49049f3760352f9c6421"}}, "title": "Institutional and behaviour-change interventions to support COVID-19 public health measures: a review by the Lancet Commission Task Force on public health measures to suppress the pandemic.", "authors": [{"family": "Lee", "given": "Jong-Koo", "initials": "JK"}, {"family": "Bullen", "given": "Chris", "initials": "C"}, {"family": "Ben Amor", "given": "Yanis", "initials": "Y"}, {"family": "Bush", "given": "Simon R", "initials": "SR"}, {"family": "Colombo", "given": "Francesca", "initials": "F"}, {"family": "Gaviria", "given": "Alejandro", "initials": "A"}, {"family": "Karim", "given": "Salim S Abdool", "initials": "SSA"}, {"family": "Kim", "given": "Booyuel", "initials": "B"}, {"family": "Lavis", "given": "John N", "initials": "JN"}, {"family": "Lazarus", "given": "Jeffrey V", "initials": "JV"}, {"family": "Lo", "given": "Yi-Chun", "initials": "YC"}, {"family": "Michie", "given": "Susan F", "initials": "SF"}, {"family": "Norheim", "given": "Ole F", "initials": "OF"}, {"family": "Oh", "given": "Juhwan", "initials": "J"}, {"family": "Reddy", "given": "Kolli Srinath", "initials": "KS"}, {"family": "Rostila", "given": "Mikael", "initials": "M"}, {"family": "S\u00e1enz", "given": "Roc\u00edo", "initials": "R"}, {"family": "Smith", "given": "Liam D G", "initials": "LDG"}, {"family": "Thwaites", "given": "John W", "initials": "JW"}, {"family": "Were", "given": "Miriam K", "initials": "MK"}, {"family": "Xue", "given": "Lan", "initials": "L"}, {"family": "(The Lancet COVID-19 Commission Task Force for Public Health Measures to Suppress the Pandemic)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Int Health", "issn": "1876-3405", "volume": null, "issue": null, "issn-l": null}, "abstract": "The Lancet COVID-19 Commission Task Force for Public Health Measures to Suppress the Pandemic was launched to identify critical points for consideration by governments on public health interventions to control coronavirus disease 2019 (COVID-19). Drawing on our review of published studies of data analytics and modelling, evidence synthesis and contextualisation, and behavioural science evidence and theory on public health interventions from a range of sources, we outline evidence for a range of institutional measures and behaviour-change measures. We cite examples of measures adopted by a range of countries, but especially jurisdictions that have, thus far, achieved low numbers of COVID-19 deaths and limited community transmission of severe acute respiratory syndrome coronavirus 2. Finally, we highlight gaps in knowledge where research should be undertaken. As countries consider long-term measures, there is an opportunity to learn, improve the response and prepare for future pandemics.", "doi": "10.1093/inthealth/ihab022", "pmid": "33974687", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "6273788"}], "notes": [], "created": "2021-05-17T18:49:29.351Z", "modified": "2021-05-17T18:49:41.581Z"}, {"entity": "publication", "iuid": "fa6a7a05e2074cd1a7402b7d09a56c8e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa6a7a05e2074cd1a7402b7d09a56c8e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa6a7a05e2074cd1a7402b7d09a56c8e"}}, "title": "High but slightly declining COVID-19 vaccine acceptance and reasons for vaccine acceptance, Finland April to December 2020.", "authors": [{"family": "Hammer", "given": "Charlotte C", "initials": "CC"}, {"family": "Cristea", "given": "Veronica", "initials": "V"}, {"family": "Dub", "given": "Timothee", "initials": "T"}, {"family": "Sivel\u00e4", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "issn-l": null, "volume": null, "issue": null, "pages": "1-19"}, "abstract": null, "doi": "10.1017/S0950268821001114", "pmid": "33972001", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0950268821001114"}], "notes": [], "created": "2021-05-17T18:56:22.538Z", "modified": "2021-07-14T08:51:02.585Z"}, {"entity": "publication", "iuid": "eadf0103347c4a33b1fe4952b6eec997", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eadf0103347c4a33b1fe4952b6eec997.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eadf0103347c4a33b1fe4952b6eec997"}}, "title": "Evidence-Based Health Informatics as the Foundation for the COVID-19 Response: A Joint Call for Action.", "authors": [{"family": "Fernandez-Luque", "given": "Luis", "initials": "L"}, {"family": "Kushniruk", "given": "Andre W", "initials": "AW"}, {"family": "Georgiou", "given": "Andrew", "initials": "A"}, {"family": "Basu", "given": "Arindam", "initials": "A"}, {"family": "Petersen", "given": "Carolyn", "initials": "C"}, {"family": "Ronquillo", "given": "Charlene", "initials": "C"}, {"family": "Paton", "given": "Chris", "initials": "C"}, {"family": "N\u00f8hr", "given": "Christian", "initials": "C"}, {"family": "Kuziemsky", "given": "Craig E", "initials": "CE"}, {"family": "Alhuwail", "given": "Dari", "initials": "D"}, {"family": "Skiba", "given": "Diane", "initials": "D"}, {"family": "Huesing", "given": "Elaine", "initials": "E"}, {"family": "Gabarron", "given": "Elia", "initials": "E"}, {"family": "Borycki", "given": "Elizabeth M", "initials": "EM"}, {"family": "Magrabi", "given": "Farah", "initials": "F"}, {"family": "Denecke", "given": "Kerstin", "initials": "K"}, {"family": "Peute", "given": "Linda W P", "initials": "LWP"}, {"family": "Topaz", "given": "Max", "initials": "M"}, {"family": "Al-Shorbaji", "given": "Najeeb", "initials": "N"}, {"family": "Lacroix", "given": "Paulette", "initials": "P"}, {"family": "Marcilly", "given": "Romaric", "initials": "R"}, {"family": "Cornet", "given": "Ronald", "initials": "R"}, {"family": "Gogia", "given": "Shashi B", "initials": "SB"}, {"family": "Kobayashi", "given": "Shinji", "initials": "S"}, {"family": "Iyengar", "given": "Sriram", "initials": "S"}, {"family": "Deserno", "given": "Thomas M", "initials": "TM"}, {"family": "Mettler", "given": "Tobias", "initials": "T"}, {"family": "Vimarlund", "given": "Vivian", "initials": "V"}, {"family": "Zhu", "given": "Xinxin", "initials": "X"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Methods Inf Med", "issn": "2511-705X", "volume": null, "issue": null, "issn-l": null}, "abstract": "As a major public health crisis, the novel coronavirus disease 2019 (COVID-19) pandemic demonstrates the urgent need for safe, effective, and evidence-based implementations of digital health. The urgency stems from the frequent tendency to focus attention on seemingly high promising digital health interventions despite being poorly validated in times of crisis.\n\nIn this paper, we describe a joint call for action to use and leverage evidence-based health informatics as the foundation for the COVID-19 response and public health interventions. Tangible examples are provided for how the working groups and special interest groups of the International Medical Informatics Association (IMIA) are helping to build an evidence-based response to this crisis.\n\nLeaders of working and special interest groups of the IMIA, a total of 26 groups, were contacted via e-mail to provide a summary of the scientific-based efforts taken to combat COVID-19 pandemic and participate in the discussion toward the creation of this manuscript. A total of 13 groups participated in this manuscript.\n\nVarious efforts were exerted by members of IMIA including (1) developing evidence-based guidelines for the design and deployment of digital health solutions during COVID-19; (2) surveying clinical informaticians internationally about key digital solutions deployed to combat COVID-19 and the challenges faced when implementing and using them; and (3) offering necessary resources for clinicians about the use of digital tools in clinical practice, education, and research during COVID-19.\n\nRigor and evidence need to be taken into consideration when designing, implementing, and using digital tools to combat COVID-19 to avoid delays and unforeseen negative consequences. It is paramount to employ a multidisciplinary approach for the development and implementation of digital health tools that have been rapidly deployed in response to the pandemic bearing in mind human factors, ethics, data privacy, and the diversity of context at the local, national, and international levels. The training and capacity building of front-line workers is crucial and must be linked to a clear strategy for evaluation of ongoing experiences.", "doi": "10.1055/s-0041-1726414", "pmid": "33975375", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:48:34.073Z", "modified": "2021-05-17T18:48:43.627Z"}, {"entity": "publication", "iuid": "aa21976a6f8245e8b4dd38c8e7bc90af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aa21976a6f8245e8b4dd38c8e7bc90af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aa21976a6f8245e8b4dd38c8e7bc90af"}}, "title": "COVID-19, Livestock Systems and Food Security in Developing Countries: A Systematic Review of an Emerging Literature.", "authors": [{"family": "Abu Hatab", "given": "Assem", "initials": "A"}, {"family": "Krautscheid", "given": "Lena", "initials": "L"}, {"family": "Boqvist", "given": "Sofia", "initials": "S"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Pathogens", "issn": "2076-0817", "volume": "10", "issue": "5", "issn-l": "2076-0817"}, "abstract": "In this paper, we carried out a systematic literature review to document the emerging scientific knowledge about COVID-19 impact on livestock systems and food security in developing countries to identify gaps and possible avenues for future research undertakings. Specifically, we systematically reviewed 68 peer-reviewed articles extracted based on rigorous selection criteria from Scopus, PubMed and ISI Web of Science databases and published between December 2019 and February 2021. Our results reveal that livestock supply chains presented an important 'intermediary' pathway through which the pandemic affected various dimensions of food security in developing countries. Although the research response has been rapid in terms of both quantity and temporal succession, we find a highly suggestive disjunction in studies analyzing the interconnections between COVID-19 pandemic, livestock systems and food security in developing countries. With respect to the livestock supply chain, the bulk of the reviewed evidence focuses on production and consumption, whereas considerably less focus is given to the pandemic's impact on intermediaries within livestock chains, including traders, intermediaries and processors. The analysis of livestock supply chain resilience revolves predominantly around the 'absorbance' and 'recovery' phases of resilience, whereas only a small subset of the literature investigates actions taken by supply chain actors to 'plan' or to 'adapt' livestock systems in order to reduce their vulnerability and enhance their overall resilience. Furthermore, food security has often been narrowly defined, with the majority of articles focusing on 'availability' and 'accessibility' to food due to the pandemic, and other dimensions of food security, including utilization, stability and sustainability, have been widely neglected. Based on our findings, we recommend future research to examine the dynamics of propagation of COVID-19 impact through livestock supply chains in order to develop more targeted interventions that enhance the capacity of developing countries to cope with this and future disruptions and mitigate their food insecurity outcomes. To this end, more holistic, integrated and resilience-based approaches are much recommended to recognize the complex nature of livestock systems in developing countries and to address the multifaceted and widespread effects of COVID-19 on food security channeled through livestock chains.", "doi": "10.3390/pathogens10050586", "pmid": "34064749", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "pathogens10050586"}], "notes": [], "created": "2021-06-04T11:23:46.972Z", "modified": "2021-06-04T11:23:46.975Z"}, {"entity": "publication", "iuid": "79c11d5578e0406d9e0a6d1106918137", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79c11d5578e0406d9e0a6d1106918137.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79c11d5578e0406d9e0a6d1106918137"}}, "title": "Registered nurses' experiences of working in the intensive care unit during the COVID-19 pandemic.", "authors": [{"family": "Bergman", "given": "Lina", "initials": "L"}, {"family": "Falk", "given": "Ann-Charlotte", "initials": "A"}, {"family": "Wolf", "given": "Axel", "initials": "A"}, {"family": "Larsson", "given": "Ing-Marie", "initials": "I"}], "type": "journal article", "published": "2021-05-10", "journal": {"title": "Nurs Crit Care", "issn": "1478-5153", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "During the pandemic, increased numbers of patients requiring intensive care unit (ICU) admission required an increase in ICU capacity, including ICU staffing with competence to care for critically ill patients. Consequently, nurses from acute care areas were called in to staff the ICU along with experienced intensive care nurses.\r\n\r\nTo describe Swedish registered nurses' experiences of caring for patients with COVID-19 in ICUs during the pandemic.\r\n\r\nMixed method survey design.\r\n\r\nAn online questionnaire was distributed through social media to registered nurses who had been working in the ICU during the COVID-19 outbreak. Data were collected for 1 week (May 2020) and analysed using content analysis and descriptive statistics.\r\n\r\nOf the 282 nurses who participated, the majority were ICU nurses (n = 151; 54%). Half of the nurses specialized in ICU reported that they were responsible for the ICU care of three or more patients during the pandemic (n = 75; 50%). Among non-intensive care nurses, only 19% received introduction to the COVID-19 ICU (n = 26). The analysis of data regarding nurses' experiences resulted in three categories: tumbling into chaos, diminished nursing care, and transition into pandemic ICU care. Participants described how patient safety and care quality were compromised, and that nursing care was severely deprioritized during the pandemic. The situation of not being able to provide nursing care resulted in ethical stress. Furthermore, an increased workload and worsened work environment affected nurses' health and well-being.\r\n\r\nThe findings from the present study indicate that nurses perceived that patient safety and quality of care were compromised during the pandemic. This resulted in ethical stress among nurses, which may have affected their physical and psychosocial well-being.\r\n\r\nThe COVID-19 pandemic had a severe impact on nurses' work environment, which could result in burnout and staff turnover.", "doi": "10.1111/nicc.12649", "pmid": "33973304", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:52:32.250Z", "modified": "2021-07-14T08:47:44.764Z"}, {"entity": "publication", "iuid": "8ce37febe6f44ed1a369d9b92a59e015", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ce37febe6f44ed1a369d9b92a59e015.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ce37febe6f44ed1a369d9b92a59e015"}}, "title": "National Swedish survey showed that child health services and routine immunisation programmes were resilient during the early COVID-19 pandemic.", "authors": [{"family": "Falkenstein Hagander", "given": "Kathy", "initials": "K"}, {"family": "Aronsson", "given": "Bernice", "initials": "B"}, {"family": "Danielsson", "given": "Madelene", "initials": "M"}, {"family": "Lepp", "given": "Tiia", "initials": "T"}, {"family": "Kulane", "given": "Asli", "initials": "A"}, {"family": "Schollin Ask", "given": "Lina", "initials": "L"}], "type": "journal article", "published": "2021-05-10", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": null, "issue": null, "issn-l": "0803-5253"}, "abstract": "Routine immunisation programmes are at risk of disruption due to the COVID-19 pandemic. This study aimed to investigate the resilience of the Swedish national immunisation programme for children up to the age of five years during the early stages of the pandemic.\n\nThis was a cross-sectional, web-based survey of regional child health offices in Sweden between 10 September and 9 October 2020. It explored the organisation of child health services during the early stages of the pandemic, focusing on routine child immunisation.\n\nAll 21 Swedish regional child health offices responded. They stated that child immunisation had been prioritised, communication with families had been intensified and there was greater flexibility at all organisational levels of child health services. In addition, the vaccine supply was sustained and child health centres remained open. However, there were periodic staff shortages, increased numbers of health visits cancelled by parents and most parent-education groups were paused.\n\nThe Swedish immunisation programme was resilient during the early COVID-19 pandemic, thanks to sustainable organisation co-ordinated by Sweden's network of regional child health offices.", "doi": "10.1111/apa.15912", "pmid": "33973264", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:53:22.196Z", "modified": "2021-05-17T18:54:07.082Z"}, {"entity": "publication", "iuid": "2a8f278f7ff54f37ae4a00a474cf4625", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2a8f278f7ff54f37ae4a00a474cf4625.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2a8f278f7ff54f37ae4a00a474cf4625"}}, "title": "Health literacy and changes in pattern of drug use among participants at the Stockholm Needle Exchange Program during the COVID-19 pandemic.", "authors": [{"family": "Lindqvist", "given": "K", "initials": "K"}, {"family": "Wallmofeldt", "given": "C", "initials": "C"}, {"family": "Holm\u00e9n", "given": "E", "initials": "E"}, {"family": "Hammarberg", "given": "A", "initials": "A"}, {"family": "K\u00e5berg", "given": "M", "initials": "M"}], "type": "journal article", "published": "2021-05-10", "journal": {"title": "Harm Reduct J", "issn": "1477-7517", "issn-l": null, "volume": "18", "issue": "1", "pages": "52"}, "abstract": "People who inject drugs may be particularly vulnerable to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) due to underlying health problems, stigma and social vulnerabilities. Harm reduction services, including needle exchange programs (NEP), have been subjected to varying degrees of disruption in the world, especially in the beginning of the coronavirus disease 2019 (COVID-19) pandemic. Compared to responses in other countries, Sweden's initial strategy toward limiting the spread and impact of COVID-19 was less restrictive to its citizens with no imposed general societal lockdown. In this study, we investigate changes in drug use patterns, utilization of NEP associated health services, COVID-19 health literacy and the prevalence of SARS-CoV-2 antibodies among NEP clients in Stockholm during the COVID-19 pandemic.\r\n\r\nNEP visits and services provided (needles/syringes, HIV and hepatitis C tests and treatment, naloxone distributed) and overall mortality among NEP clients between January 1 and October 31, 2020, were used for trend analyses in comparison with corresponding 2019 data. Between July 27 and October 2, 2020, NEP clients (n = 232) responded to a 27 item COVID-19 Health Literacy Questionnaire. SARS CoV-2 IgG antibody tests (n = 779) were performed between June 15 and October 31, 2020.\r\n\r\nDuring the COVID-19 pandemic number of clients, client visits, naloxone distribution and HCV tests remained stable compared to 2019, while distribution of needles/syringes increased (p < 0.0001); number of HIV tests and HCV treatments decreased (p < 0.05); and mortality decreased (< 0.01). Overall, the level of health literacy concerning transmission routes and protective measures was high. SARS-CoV-2 antibody prevalence was 5.4% (95% CI 4.0-7.2).\r\n\r\nThe Stockholm NEP managed to maintain a high level of clients and services during the pandemic. In general, COVID-19 health literacy was adequate and the overall SARS-CoV-2 antibody prevalence was low compared to the general population, which highlights a need for prioritized and targeted COVID-19 vaccination among PWID.", "doi": "10.1186/s12954-021-00499-z", "pmid": "33971892", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12954-021-00499-z"}, {"db": "pmc", "key": "PMC8107802"}], "notes": [], "created": "2021-05-17T18:59:08.075Z", "modified": "2021-07-14T08:50:00.818Z"}, {"entity": "publication", "iuid": "039f7f7aa71844cb935de8f4a197c76d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/039f7f7aa71844cb935de8f4a197c76d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/039f7f7aa71844cb935de8f4a197c76d"}}, "title": "Determinants of SARS-CoV-2 Impacts on Small-Scale Commercial Broiler Production Systems in Egypt: Implications for Mitigation Strategies.", "authors": [{"family": "Abu Hatab", "given": "Assem", "initials": "A"}, {"family": "Liu", "given": "Zhen", "initials": "Z"}, {"family": "Nasser", "given": "Asmaa", "initials": "A"}, {"family": "Esmat", "given": "Abourehab", "initials": "A"}], "type": "journal article", "published": "2021-05-10", "journal": {"title": "Animals (Basel)", "issn": "2076-2615", "volume": "11", "issue": "5", "issn-l": null}, "abstract": "As in many other countries, the outbreak of the COVID-19 pandemic, together with subsequent government containment measures, posed significant challenges to small-scale broiler production systems in Egypt. Based on a survey of 205 specialist small-scale commercial broiler farms (SCBFs) consisting of both farm-based and household-based production systems, this study identifies the primary pathways through which COVID-19 has affected SCBFs and investigates the determinants of farm perception of these effects. A polychoric principal component analysis sorted the effects of the pandemic on the SCBFs surveyed into five categories, namely, input availability, production and operational costs, labor and human resources, consumer demand and sales, and farm finances. Next, five ordered logit models were constructed to examine the determinants of the SCBFs' perception of each category of these effects. Generally, the empirical results revealed that COVID-19 affected SCBFs heterogeneously based on their management and production systems and resource endowment. Female-led and household-based SCBFs perceived significantly greater COVID-19 effects. In contrast, individually owned farms and those with membership of poultry producer organizations and larger total asset values perceived fewer effects. In addition, SCBFs operating in both local and provincial markets were less likely to perceive negative effects from the pandemic on their broiler farming activities. Although the adoption of strict and immediate containment measures was essential for controlling the virus and protecting public health, our results indicate that policy responses to COVID-19 must consider the likely effects on small businesses such as SCBFs since disruptions to such socioeconomically important supply chains will intensify human suffering from the pandemic. Overall, our findings provide important implications for the formulation of effective strategies for mitigating the impact of COVID-19 on small-scale broiler production systems in Egypt and enhancing their preparedness and resilience to future pandemics, natural hazard risks, and market shocks.", "doi": "10.3390/ani11051354", "pmid": "34068757", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ani11051354"}], "notes": [], "created": "2021-06-04T11:18:36.120Z", "modified": "2021-06-04T11:18:36.144Z"}, {"entity": "publication", "iuid": "e808459a76314069ba46438ca769f8c3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e808459a76314069ba46438ca769f8c3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e808459a76314069ba46438ca769f8c3"}}, "title": "A simple cognitive task intervention to prevent intrusive memories after trauma in patients in the Emergency Department: A randomized controlled trial terminated due to COVID-19.", "authors": [{"family": "Kanstrup", "given": "Marie", "initials": "M"}, {"family": "Singh", "given": "Laura", "initials": "L"}, {"family": "G\u00f6ransson", "given": "Katarina E", "initials": "KE"}, {"family": "Gamble", "given": "Beau", "initials": "B"}, {"family": "Taylor", "given": "Rod S", "initials": "RS"}, {"family": "Iyadurai", "given": "Lalitha", "initials": "L"}, {"family": "Moulds", "given": "Michelle L", "initials": "ML"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}], "type": "journal article", "published": "2021-05-10", "journal": {"title": "BMC Res Notes", "issn": "1756-0500", "volume": "14", "issue": "1", "pages": "176", "issn-l": null}, "abstract": "This randomised controlled trial (RCT) aimed to investigate the effects of a simple cognitive task intervention on intrusive memories (\"flashbacks\") and associated symptoms following a traumatic event. Patients presenting to a Swedish emergency department (ED) soon after a traumatic event were randomly allocated (1:1) to the simple cognitive task intervention (memory cue + mental rotation instructions + computer game \"Tetris\" for at least 20 min) or control (podcast, similar time). We planned follow-ups at one-week, 1-month, and where possible, 3- and 6-months post-trauma. Anticipated enrolment was N = 148.\n\nThe RCT was terminated prematurely after recruiting N = 16 participants. The COVID-19 pandemic prevented recruitment/testing in the ED because: (i) the study required face-to-face contact between participants, psychology researchers, ED staff, and patients, incurring risk of virus transmission; (ii) the host ED site received COVID-19 patients; and (iii) reduced flow of patients otherwise presenting to the ED in non-pandemic conditions (e.g. after trauma). We report on delivery of study procedures, recruitment, treatment adherence, outcome completion (primary outcome: number of intrusive memories during week 5), attrition, and limitations. The information presented and limitations may enable our group and others to learn from this terminated study. Trial registration ClinicalTrials.gov: NCT04185155 (04-12-2019).", "doi": "10.1186/s13104-021-05572-1", "pmid": "33971951", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13104-021-05572-1"}, {"db": "pmc", "key": "PMC8107806"}, {"db": "ClinicalTrials.gov", "key": "NCT04185155"}], "notes": [], "created": "2021-05-17T18:58:33.047Z", "modified": "2021-05-17T18:58:33.070Z"}, {"entity": "publication", "iuid": "bf5f0fa24fcf48df934cf1cd3aaaeb64", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf5f0fa24fcf48df934cf1cd3aaaeb64.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf5f0fa24fcf48df934cf1cd3aaaeb64"}}, "title": "Reasons for physician-related variability in end-of-life decision-making in intensive care.", "authors": [{"family": "Nordenskj\u00f6ld Syrous", "given": "Alma", "initials": "A"}, {"family": "Malmgren", "given": "Johan", "initials": "J"}, {"family": "Odenstedt Herg\u00e8s", "given": "Helena", "initials": "H"}, {"family": "Olausson", "given": "Sepideh", "initials": "S"}, {"family": "Kock-Redfors", "given": "Maria", "initials": "M"}, {"family": "\u00c5g\u00e5rd", "given": "Anders", "initials": "A"}, {"family": "Block", "given": "Linda", "initials": "L"}], "type": "journal article", "published": "2021-05-08", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "volume": null, "issue": null, "issn-l": "0001-5172"}, "abstract": "There is increasing evidence that the individual physician is the main factor influencing variability in end-of-life decision-making in intensive care units. End-of-life decisions are complex and should be adapted to each patient. Physician-related variability is problematic as it may result in unequal assessments that affect patient outcomes. The primary aim of this study was to investigate factors contributing to physician-related variability in end-of-life decision-making.\n\nThis is a qualitative sub-study of a previously conducted study. In-depth thematic analysis of semi-structured interviews with 19 critical care specialists from five different Swedish intensive care units was performed. Interviews took place between February 1, 2017, and May 31, 2017.\n\nFactors influencing physician-related variability consisted of different assessment of patient preferences, as well as intensivists' personality and values. Personality was expressed mainly through pace and determination in the decision-making process. Personal prejudices appeared in decisions, but few respondents had personally witnessed this. Avoidance of criticism and conflicts as well as individual strategies for emotional coping were other factors that influenced physician-related variability. Many respondents feared criticism for making their assessments, and the challenging nature of end-of-life decision-making lead to avoidance as well as emotional stress.\n\nVariability in end-of-life decision-making is an important topic that needs further investigation. It is imperative that such variability be acknowledged and addressed in a more formal and transparent manner. The ethical issues faced by intensivists have recently been compounded by the devastating impact of the COVID-19 pandemic, demonstrating in profound terms the importance of the topic.", "doi": "10.1111/aas.13842", "pmid": "33964009", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-17T19:08:32.486Z", "modified": "2021-05-17T19:08:32.496Z"}, {"entity": "publication", "iuid": "bb47ae65f9ac4973b315454f08f44804", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb47ae65f9ac4973b315454f08f44804.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb47ae65f9ac4973b315454f08f44804"}}, "title": "Corrigendum to: The influence of the SARS-CoV-2 pandemic on esophagogastric cancer services: an international survey of esophagogastric surgeons.", "authors": [{"family": "Kamarajah", "given": "Sivesh K", "initials": "SK"}, {"family": "Markar", "given": "Sheraz R", "initials": "SR"}, {"family": "Singh", "given": "Pritam", "initials": "P"}, {"family": "Griffiths", "given": "Ewen A", "initials": "EA"}, {"family": "Oesophagogastric Anastomosis Audit Group", "given": "", "initials": ""}], "type": "published erratum", "published": "2021-05-08", "journal": {"title": "Dis Esophagus", "issn": "1442-2050", "volume": null, "issue": null, "issn-l": "1120-8694"}, "abstract": null, "doi": "10.1093/dote/doab035", "pmid": "33963749", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "6272293"}], "notes": [], "created": "2021-05-17T19:07:32.983Z", "modified": "2021-05-17T19:08:00.109Z"}, {"entity": "publication", "iuid": "0fc45db4f8184778a5ff2740cd42ec6b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0fc45db4f8184778a5ff2740cd42ec6b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0fc45db4f8184778a5ff2740cd42ec6b"}}, "title": "Tumor Treating Fields for Glioblastoma Therapy During the COVID-19 Pandemic.", "authors": [{"family": "Gatson", "given": "Na Tosha N", "initials": "NTN"}, {"family": "Barnholtz-Sloan", "given": "Jill", "initials": "J"}, {"family": "Drappatz", "given": "Jan", "initials": "J"}, {"family": "Henriksson", "given": "Roger", "initials": "R"}, {"family": "Hottinger", "given": "Andreas F", "initials": "AF"}, {"family": "Hinoul", "given": "Piet", "initials": "P"}, {"family": "Kruchko", "given": "Carol", "initials": "C"}, {"family": "Puduvalli", "given": "Vinay K", "initials": "VK"}, {"family": "Tran", "given": "David D", "initials": "DD"}, {"family": "Wong", "given": "Eric T", "initials": "ET"}, {"family": "Glas", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2021-05-07", "journal": {"title": "Front Oncol", "issn": "2234-943X", "volume": "11", "issue": null, "pages": "679702", "issn-l": null}, "abstract": "The COVID-19 pandemic has placed excessive strain on health care systems and is especially evident in treatment decision-making for cancer patients. Glioblastoma (GBM) patients are among the most vulnerable due to increased incidence in the elderly and the short survival time. A virtual meeting was convened on May 9, 2020 with a panel of neuro-oncology experts with experience using Tumor Treating Fields (TTFields). The objective was to assess the risk-to-benefit ratio and provide guidance for using TTFields in GBM during the COVID-19 pandemic.\n\nTopics discussed included support and delivery of TTFields during the COVID-19 pandemic, concomitant use of TTFields with chemotherapy, and any potential impact of TTFields on the immune system in an intrinsically immunosuppressed GBM population. Special consideration was given to TTFields' use in elderly patients and in combination with radiotherapy regimens. Finally, the panel discussed the need to better capture data on COVID-19positive brain tumor patients to analyze longitudinal outcomes and changes in treatment decision-making during the pandemic.\n\nTTFields is a portable home-use device which can be managed via telemedicine and safely used in GBM patients during the COVID-19 pandemic. TTFields has no known immunosuppressive effects which is important during a crisis where other treatment methods might be limited, especially for elderly patients with multiple co-morbidities. It is too early to estimate the full impact of COVID-19 on the global healthcare system and on patient outcomes and the panel strongly recommended collaboration with existing cancer COVID-19 registries to follow CNS tumor patients.", "doi": "10.3389/fonc.2021.679702", "pmid": "34026655", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8139188"}], "notes": [], "created": "2021-05-29T16:22:39.733Z", "modified": "2021-05-29T16:22:39.744Z"}, {"entity": "publication", "iuid": "cd5dcd1a8c0947f2aa56016df442cd57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd5dcd1a8c0947f2aa56016df442cd57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd5dcd1a8c0947f2aa56016df442cd57"}}, "title": "How mobility restrictions policy and atmospheric conditions impacted air quality in the State of S\u00e3o Paulo during the COVID-19 outbreak.", "authors": [{"family": "Rudke", "given": "A P", "initials": "AP"}, {"family": "Martins", "given": "J A", "initials": "JA"}, {"family": "de Almeida", "given": "D S", "initials": "DS"}, {"family": "Martins", "given": "L D", "initials": "LD"}, {"family": "Beal", "given": "A", "initials": "A"}, {"family": "Hallak", "given": "R", "initials": "R"}, {"family": "Freitas", "given": "E D", "initials": "ED"}, {"family": "Andrade", "given": "M F", "initials": "MF"}, {"family": "Foroutan", "given": "H", "initials": "H"}, {"family": "Baek", "given": "B H", "initials": "BH"}, {"family": "de A Albuquerque", "given": "T T", "initials": "TT"}], "type": "journal article", "published": "2021-05-07", "journal": {"title": "Environ Res", "issn": "1096-0953", "volume": null, "issue": null, "pages": "111255", "issn-l": "0013-9351"}, "abstract": "Mobility restrictions are among actions to prevent the spread of the COVID-19 pandemic and have been pointed as reasons for improving air quality, especially in large cities. However, it is crucial to assess the impact of atmospheric conditions on air quality and air pollutant dispersion in the face of the potential variability of all sources. In this study, the impact of mobility restrictions on the air quality was analyzed for the most populous Brazilian State, S\u00e3o Paulo, severely impacted by COVID-19. Ground-based air quality data (PM 10, PM2.5, CO, SO2, NOx, NO2, NO, and O3) were used from 50 automatic air quality monitoring stations to evaluate the changes in concentrations before (January 01 - March 25) and during the partial quarantine (March 16 - June 30). Rainfall, fires, and daily cell phone mobility data were also used as supplementary information to the analyses. The Mann-Whitney U test was used to assess the heterogeneity of the air quality data during and before mobility restrictions. In general, the results demonstrated no substantial improvements in air quality for most of the pollutants when comparing before and during restrictions periods. Besides, when the analyzed period of 2020 is compared with the year 2019, there is no significant air quality improvement in the S\u00e3o Paulo State. However, special attention should be given to the Metropolitan Area of S\u00e3o Paulo (MASP), due to the vast population residing in this area and exposed to air pollution. The region reached an average decrease of 29% in CO, 28% in NOx, 40% in NO, 19% in SO2, 15% in PM2.5, and 8% in PM10 concentrations during the mobility restrictions period compared to the same period in 2019. The only pollutant that showed an increase in concentration was ozone, with a 20% increase compared to 2019 during the mobility restrictions period. Before the mobility restrictions period, the region reached an average decrease of 30% in CO, 39% in NOx, 63% in NO, 12% in SO2, 23% in PM2.5, 18% in PM10, and 16% in O3 concentrations when compared to the same period in 2019. On the other hand, Cubat\u00e3o, a highly industrialized area, showed statistically significant increases above 20% for most monitored pollutants in both periods of 2020 compared to 2019. This study reinforces that the main driving force of pollutant concentration variability is the dynamics of the atmosphere at its various time scales. An abnormal rainy season, with above average rainfall before the restrictions and below average after it, generated a scenario in which the probable significant reductions in emissions did not substantially affect the concentration of pollutants.", "doi": "10.1016/j.envres.2021.111255", "pmid": "33971134", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0013-9351(21)00549-1"}], "notes": [], "created": "2021-05-17T19:01:41.083Z", "modified": "2021-05-17T19:01:41.093Z"}, {"entity": "publication", "iuid": "d549138e93274c768eeb439c799261d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d549138e93274c768eeb439c799261d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d549138e93274c768eeb439c799261d0"}}, "title": "The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity.", "authors": [{"family": "Osuchowski", "given": "Marcin F", "initials": "MF"}, {"family": "Winkler", "given": "Martin S", "initials": "MS"}, {"family": "Skirecki", "given": "Tomasz", "initials": "T"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "Shankar-Hari", "given": "Manu", "initials": "M"}, {"family": "Lachmann", "given": "Gunnar", "initials": "G"}, {"family": "Monneret", "given": "Guillaume", "initials": "G"}, {"family": "Venet", "given": "Fabienne", "initials": "F"}, {"family": "Bauer", "given": "Michael", "initials": "M"}, {"family": "Brunkhorst", "given": "Frank M", "initials": "FM"}, {"family": "Weis", "given": "Sebastian", "initials": "S"}, {"family": "Garcia-Salido", "given": "Alberto", "initials": "A"}, {"family": "Kox", "given": "Matthijs", "initials": "M"}, {"family": "Cavaillon", "given": "Jean-Marc", "initials": "J"}, {"family": "Uhle", "given": "Florian", "initials": "F"}, {"family": "Weigand", "given": "Markus A", "initials": "MA"}, {"family": "Floh\u00e9", "given": "Stefanie B", "initials": "SB"}, {"family": "Wiersinga", "given": "W Joost", "initials": "WJ"}, {"family": "Almansa", "given": "Raquel", "initials": "R"}, {"family": "de la Fuente", "given": "Amanda", "initials": "A"}, {"family": "Martin-Loeches", "given": "Ignacio", "initials": "I"}, {"family": "Meisel", "given": "Christian", "initials": "C"}, {"family": "Spinetti", "given": "Thibaud", "initials": "T"}, {"family": "Schefold", "given": "Joerg C", "initials": "JC"}, {"family": "Cilloniz", "given": "Catia", "initials": "C"}, {"family": "Torres", "given": "Antoni", "initials": "A"}, {"family": "Giamarellos-Bourboulis", "given": "Evangelos J", "initials": "EJ"}, {"family": "Ferrer", "given": "Ricard", "initials": "R"}, {"family": "Girardis", "given": "Massimo", "initials": "M"}, {"family": "Cossarizza", "given": "Andrea", "initials": "A"}, {"family": "Netea", "given": "Mihai G", "initials": "MG"}, {"family": "van der Poll", "given": "Tom", "initials": "T"}, {"family": "Bermejo-Mart\u00edn", "given": "Jes\u00fas F", "initials": "JF"}, {"family": "Rubio", "given": "Ignacio", "initials": "I"}], "type": "journal article", "published": "2021-05-06", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "issn-l": "2213-2600", "volume": null, "issue": null, "pages": null}, "abstract": "The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with devastating consequences. While the medical community has gained insight into the epidemiology of COVID-19, important questions remain about the clinical complexities and underlying mechanisms of disease phenotypes. Severe COVID-19 most commonly involves respiratory manifestations, although other systems are also affected, and acute disease is often followed by protracted complications. Such complex manifestations suggest that SARS-CoV-2 dysregulates the host response, triggering wide-ranging immuno-inflammatory, thrombotic, and parenchymal derangements. We review the intricacies of COVID-19 pathophysiology, its various phenotypes, and the anti-SARS-CoV-2 host response at the humoral and cellular levels. Some similarities exist between COVID-19 and respiratory failure of other origins, but evidence for many distinctive mechanistic features indicates that COVID-19 constitutes a new disease entity, with emerging data suggesting involvement of an endotheliopathy-centred pathophysiology. Further research, combining basic and clinical studies, is needed to advance understanding of pathophysiological mechanisms and to characterise immuno-inflammatory derangements across the range of phenotypes to enable optimum care for patients with COVID-19.", "doi": "10.1016/S2213-2600(21)00218-6", "pmid": "33965003", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(21)00218-6"}, {"db": "pmc", "key": "PMC8102044"}], "notes": [], "created": "2021-05-17T19:08:57.517Z", "modified": "2021-05-17T19:09:49.278Z"}, {"entity": "publication", "iuid": "60a03d4e003f4e54a08b1e41bde1fc2d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60a03d4e003f4e54a08b1e41bde1fc2d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60a03d4e003f4e54a08b1e41bde1fc2d"}}, "title": "Old Overnight: Experiences of Age-Based Recommendations in Response to the COVID-19 Pandemic in Sweden.", "authors": [{"family": "Nilsson", "given": "Gabriella", "initials": "G"}, {"family": "Ekstam", "given": "Lisa", "initials": "L"}, {"family": "Axmon", "given": "Anna", "initials": "A"}, {"family": "Andersson", "given": "Janicke", "initials": "J"}], "type": "journal article", "published": "2021-05-06", "journal": {"title": "J Aging Soc Policy", "issn": "1545-0821", "issn-l": null, "volume": null, "issue": null, "pages": "1-21"}, "abstract": "The Swedish response to the COVID-19 pandemic included age-based recommendations of voluntary quarantine specifically for those 70 years of age or older. This paper investigates the experiences of a sudden change of policy in the form of an age restriction that trumped the contemporary active aging ideal. A web-based qualitative survey was conducted in April 2020. Through manual coding of a total of 851 responses, six different ways of relating to the age-based recommendations were identified. The results show that age is not an unproblematic governing principle. Instead, in addition to protecting a vulnerable group, the age-based recommendation meant deprivation of previously assigned individual responsibility and, consequently, autonomy. It is shown how respondents handled this tension through varying degrees of compliance and resistance. Findings highlight the importance of continuously tracking the long-term consequences of age-based policy to avoid negative self-image and poorer health among older adults.", "doi": "10.1080/08959420.2021.1925042", "pmid": "34010122", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-05-20T14:37:14.738Z", "modified": "2021-07-14T08:26:56.251Z"}, {"entity": "publication", "iuid": "db3b2d224a54435bad4d993f3797ac03", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db3b2d224a54435bad4d993f3797ac03.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db3b2d224a54435bad4d993f3797ac03"}}, "title": "International transfers of personal data for health research following Schrems II: a problem in need of a solution.", "authors": [{"family": "Hallinan", "given": "Dara", "initials": "D"}, {"family": "Bernier", "given": "Alexander", "initials": "A"}, {"family": "Cambon-Thomsen", "given": "Anne", "initials": "A"}, {"family": "Crawley", "given": "Francis P", "initials": "FP"}, {"family": "Dimitrova", "given": "Diana", "initials": "D"}, {"family": "Medeiros", "given": "Claudia Bauzer", "initials": "CB"}, {"family": "Nilsonne", "given": "Gustav", "initials": "G"}, {"family": "Parker", "given": "Simon", "initials": "S"}, {"family": "Pickering", "given": "Brian", "initials": "B"}, {"family": "Rennes", "given": "St\u00e9phanie", "initials": "S"}], "type": "journal article", "published": "2021-05-06", "journal": {"title": "Eur J Hum Genet", "issn": "1476-5438", "volume": null, "issue": null, "issn-l": null}, "abstract": "On 16 July 2020, the Court of Justice of the European Union issued their decision in the Schrems II case concerning Facebook's transfers of personal data from the EU to the US. The decision may have significant effects on the legitimate transfer of personal data for health research purposes from the EU. This article aims: (i) to outline the consequences of the Schrems II decision for the sharing of personal data for health research between the EU and third countries, particularly in the context of the COVID-19 pandemic; and, (ii) to consider certain options available to address the consequences of the decision and to facilitate international data exchange for health research moving forward.", "doi": "10.1038/s41431-021-00893-y", "pmid": "33953344", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41431-021-00893-y"}, {"db": "pmc", "key": "PMC8099706"}], "notes": [], "created": "2021-05-17T19:04:18.502Z", "modified": "2021-05-17T19:04:35.741Z"}, {"entity": "publication", "iuid": "8afa2e52f9f84ccc9077e945af9211de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8afa2e52f9f84ccc9077e945af9211de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8afa2e52f9f84ccc9077e945af9211de"}}, "title": "Dying from COVID-19 in nursing homes-sex differences in symptom occurrence.", "authors": [{"family": "Martinsson", "given": "Lisa", "initials": "L"}, {"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "Bergstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Staffan", "initials": "S"}], "type": "journal article", "published": "2021-05-06", "journal": {"title": "BMC Geriatr", "issn": "1471-2318", "volume": "21", "issue": "1", "pages": "294", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19), is a disease with diverse presentation. Several studies have shown different occurrence of symptoms for women and men, but no studies have been found examining sex differences in clinical presentation for nursing home residents dying from COVID-19. The objective of this study was to describe sex and age differences and the impact of a dementia diagnosis on symptom occurrence during the last week in life for persons dying from COVID-19 in nursing homes.\n\nThis is a population-based retrospective study based on data from the Swedish Register of Palliative Care. A total of 1994 residents aged 65 or older who died from COVID-19 in nursing homes were identified. The impact of sex, age and a dementia diagnosis on six different symptoms was analysed using chi2-test and multivariate logistic regression.\n\nResidents dying from COVID-19 were more often men (p < .002). Men more often had dyspnoea and death rattles (p < .001). Nausea was more common in women (p < .001). No sex differences in the occurrence of pain, anxiety or confusion were seen. Dyspnoea and nausea were less commonly reported in residents with dementia (p < .001).\n\nWe found sex differences in symptom presentation for fatal COVID-19 in nursing home settings which remained after adjusting for age. Residents with a dementia diagnosis had fewer symptoms reported before death compared to those without dementia. Clinical presentation of fatal COVID-19 differs between women and men in nursing homes. Residents with fatal COVID-19 present with more unspecific and less prominent symptoms when also suffering from dementia.", "doi": "10.1186/s12877-021-02228-4", "pmid": "33957890", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12877-021-02228-4"}, {"db": "pmc", "key": "PMC8100361"}], "notes": [], "created": "2021-05-17T19:06:20.921Z", "modified": "2021-05-17T19:06:20.931Z"}, {"entity": "publication", "iuid": "935b8ada86fb4f158abf4c9e4ff4e452", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/935b8ada86fb4f158abf4c9e4ff4e452.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/935b8ada86fb4f158abf4c9e4ff4e452"}}, "title": "Comparison of Immunological Profiles of SARS-CoV-2 Variants in the COVID-19 Pandemic Trends: An Immunoinformatics Approach.", "authors": [{"family": "Mallavarpu Ambrose", "given": "Jenifer", "initials": "J"}, {"family": "Priya Veeraraghavan", "given": "Vishnu", "initials": "V"}, {"family": "Kullappan", "given": "Malathi", "initials": "M"}, {"family": "Chellapandiyan", "given": "Poongodi", "initials": "P"}, {"family": "Krishna Mohan", "given": "Surapaneni", "initials": "S"}, {"family": "Manivel", "given": "Vivek Anand", "initials": "VA"}], "type": "journal article", "published": "2021-05-06", "journal": {"title": "Antibiotics (Basel)", "issn": "2079-6382", "volume": "10", "issue": "5", "issn-l": null}, "abstract": "The current dynamics of the COVID-19 pandemic have become a serious concern with the emergence of a series of mutant variants of the SARS-CoV-2 virus. Unlike the previous strain, it is reported that the descendants are associated with increased risk of transmission yet causing less impact in terms of hospital admission, the severity of illness, or mortality. Moreover, the vaccine efficacy is also not believed to vary among the population depending on the variants of the virus and ethnicity. It has been determined that the mutations recorded in the spike gene and protein of the newly evolved viruses are specificallyresponsible for this transformation in the behavior of the virus and its disease condition. Hence, this study aimed to compare the immunogenic profiles of the spike protein from the latest variants of the SARS-CoV-2 virus concerning the probability of COVID-19 severity. Genome sequences of the latest SARS-CoV-2 variants were obtained from GISAID and NCBI repositories. The translated protein sequences were run against T-cell and B-cell epitope prediction tools. Subsequently, antigenicity, immunogenicity, allergenicity, toxicity, and conservancy of the identified epitopes were ascertained using various prediction servers. Only the non-allergic and non-toxic potential epitopes were matched for population relevance by using the Human Leucocyte Antigen population registry in IEDB. Finally, the selected epitopes were validated by docking and simulation studies. The evaluated immunological parameters would concurrently reveal the severity of COVID-19, determining the infection rate of the pathogen. Our immunoinformatics approach disclosed that spike protein of the five variants was capable of forming potential T and B-cell epitopes with varying immune responses. Although the Wuhan strain showed a high number of epitope/HLA combinations, relatively less antigenicity and higher immunogenicity results in poor neutralizing capacity, which could be associated with increased disease severity. Our data demonstrate that increased viral antigenicity with moderate to high immunogenicity, and several potential epitope/HLA combinations in England strain, the USA, India, and South Africa variants, could possess a high neutralizing ability. Therefore, our findings reinforce that the newly circulating variants of SARS-CoV-2 might be associated with more infectiousness and less severe disease condition despite their greater viremia, as reported in the recent COVID-19 cases, whichconsequently determine their increased epidemiological fitness.", "doi": "10.3390/antibiotics10050535", "pmid": "34066389", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "antibiotics10050535"}], "notes": [], "created": "2021-06-04T11:21:05.121Z", "modified": "2021-06-04T11:21:21.712Z"}, {"entity": "publication", "iuid": "8ffd2261bef943428c8755ef205b6cb9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ffd2261bef943428c8755ef205b6cb9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ffd2261bef943428c8755ef205b6cb9"}}, "title": "Assessing the consequences of quarantines during a pandemic.", "authors": [{"family": "Forslid", "given": "Rikard", "initials": "R"}, {"family": "Herzing", "given": "Mathias", "initials": "M"}], "type": "journal article", "published": "2021-05-06", "journal": {"title": "Eur J Health Econ", "issn": "1618-7601", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "This paper analyzes the epidemiological and economic effects of quarantines. We use a basic epidemiological model, a SEIR-model, that is calibrated to roughly resemble the COVID-19 pandemic, and we assume that individuals that become infected or are isolated on average lose a share of their productivity. An early quarantine postpones but does not alter the course of the pandemic at a cost that increases in the duration and the extent of the quarantine. For quarantines at later stages of the pandemic there is a trade-off between lowering the peak level of infectious people on the one hand and minimizing fatalities and economic losses on the other hand. A longer quarantine dampens the peak level of infectious people and also reduces the total number of infected persons but increases economic losses. Both the peak level of infectious individuals and the total share of the population that will have been infected are U-shaped in relation to the share of the population in quarantine, while economic costs increase in this share. In particular, a quarantine covering a moderate share of the population leads to a lower peak, fewer deaths and lower economic costs, but it implies that the peak of the pandemic occurs earlier.", "doi": "10.1007/s10198-021-01310-3", "pmid": "33956249", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10198-021-01310-3"}, {"db": "pmc", "key": "PMC8100945"}], "notes": [], "created": "2021-05-17T19:04:55.024Z", "modified": "2021-07-14T08:24:40.283Z"}, {"entity": "publication", "iuid": "3794415570724752b202ae478473faa3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3794415570724752b202ae478473faa3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3794415570724752b202ae478473faa3"}}, "title": "Microvascular Dysfunction in Patients with Critical COVID-19, A Pilot Study.", "authors": [{"family": "Tehrani", "given": "Sara", "initials": "S"}, {"family": "Gille-Johnson", "given": "Patrik", "initials": "P"}], "type": "journal article", "published": "2021-05-04", "journal": {"title": "Shock", "issn": "1540-0514", "volume": null, "issue": null, "issn-l": null}, "abstract": "Endothelial and microvascular dysfunction may be a key pathogenic feature of severe COVID-19. The aim of this study was to investigate endothelial-dependent and endothelial-independent skin microvascular reactivity in patients with critical COVID-19.\n\nTwelve patients with COVID-19 treated with non-invasive or invasive mechanical ventilation were included in the study. We investigated skin microvascular reactivity on two separate days during hospitalization (study day 1 and 2) and at least three months after disease onset (study day 3). Twelve controls with no confirmed or suspected COVID-19 infection during 2020 were also examined. Skin perfusion was investigated through Laser Speckle Contrast Imaging (LSCI) before and after iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP) to determine the endothelial-dependent and the endothelial-independent vasodilation, respectively.\n\nCompared to controls, patients with critical COVID-19 had higher basal skin perfusion and reduced responses to endothelial-dependent (ACh, p = 0.002) and endothelial-independent (SNP, p = 0.01) vasodilator drugs on study day 1. In addition, the ACh/SNP ratio was significantly reduced in patients (0.50 \u00b1 0.36 versus 0.91 \u00b1 0.49 in controls, p = 0.02). Three months after disease onset, surviving patients tended to have reduced ACh-mediated vasodilation compared to controls (p = 0.08).\n\nThis small-sized pilot study demonstrates that critical COVID-19 infection is associated with microvascular impairment and, in particular, a markedly reduced endothelial function. Our results also suggest that microvascular function may not be fully recovered three months after disease onset.", "doi": "10.1097/SHK.0000000000001803", "pmid": "33958544", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00024382-900000000-97251"}], "notes": [], "created": "2021-05-17T19:06:47.746Z", "modified": "2021-05-17T19:06:47.768Z"}, {"entity": "publication", "iuid": "449ea5b1c2084fbeb52732384922e8cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/449ea5b1c2084fbeb52732384922e8cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/449ea5b1c2084fbeb52732384922e8cb"}}, "title": "Hairy cell leukemia and COVID-19 adaptation of treatment guidelines.", "authors": [{"family": "Grever", "given": "Michael", "initials": "M"}, {"family": "Andritsos", "given": "Leslie", "initials": "L"}, {"family": "Banerji", "given": "Versha", "initials": "V"}, {"family": "Barrientos", "given": "Jacqueline C", "initials": "JC"}, {"family": "Bhat", "given": "Seema", "initials": "S"}, {"family": "Blachly", "given": "James S", "initials": "JS"}, {"family": "Call", "given": "Timothy", "initials": "T"}, {"family": "Cross", "given": "Matthew", "initials": "M"}, {"family": "Dearden", "given": "Claire", "initials": "C"}, {"family": "Demeter", "given": "Judit", "initials": "J"}, {"family": "Dietrich", "given": "Sasha", "initials": "S"}, {"family": "Falini", "given": "Brunangelo", "initials": "B"}, {"family": "Forconi", "given": "Francesco", "initials": "F"}, {"family": "Gladstone", "given": "Douglas E", "initials": "DE"}, {"family": "Gozzetti", "given": "Alessandro", "initials": "A"}, {"family": "Iyengar", "given": "Sunil", "initials": "S"}, {"family": "Johnston", "given": "James B", "initials": "JB"}, {"family": "Juliusson", "given": "Gunnar", "initials": "G"}, {"family": "Kraut", "given": "Eric", "initials": "E"}, {"family": "Kreitman", "given": "Robert J", "initials": "RJ"}, {"family": "Lauria", "given": "Francesco", "initials": "F"}, {"family": "Lozanski", "given": "Gerard", "initials": "G"}, {"family": "Parikh", "given": "Sameer A", "initials": "SA"}, {"family": "Park", "given": "Jae", "initials": "J"}, {"family": "Polliack", "given": "Aaron", "initials": "A"}, {"family": "Ravandi", "given": "Farhad", "initials": "F"}, {"family": "Robak", "given": "Tadeusz", "initials": "T"}, {"family": "Rogers", "given": "Kerry A", "initials": "KA"}, {"family": "Saven", "given": "Alan", "initials": "A"}, {"family": "Seymour", "given": "John F", "initials": "JF"}, {"family": "Tadmor", "given": "Tamar", "initials": "T"}, {"family": "Tallman", "given": "Martin S", "initials": "MS"}, {"family": "Tam", "given": "Constantine S", "initials": "CS"}, {"family": "Tiacci", "given": "Enrico", "initials": "E"}, {"family": "Troussard", "given": "Xavier", "initials": "X"}, {"family": "Zent", "given": "Clive", "initials": "C"}, {"family": "Zenz", "given": "Thorsten", "initials": "T"}, {"family": "Zinzani", "given": "Pier Luigi", "initials": "PL"}, {"family": "W\u00f6rmann", "given": "Bernhard", "initials": "B"}], "type": "journal article", "published": "2021-05-04", "journal": {"title": "Leukemia", "issn": "1476-5551", "volume": null, "issue": null, "issn-l": null}, "abstract": "Standard treatment options in classic HCL (cHCL) result in high response rates and near normal life expectancy. However, the disease itself and the recommended standard treatment are associated with profound and prolonged immunosuppression, increasing susceptibility to infections and the risk for a severe course of COVID-19. The Hairy Cell Leukemia Foundation (HCLF) has recently convened experts and discussed different clinical strategies for the management of these patients. The new recommendations adapt the 2017 consensus for the diagnosis and management with cHCL to the current COVID-19 pandemic. They underline the option of active surveillance in patients with low but stable blood counts, consider the use of targeted and non-immunosuppressive agents as first-line treatment for cHCL, and give recommendations on preventive measures against COVID-19.", "doi": "10.1038/s41375-021-01257-7", "pmid": "33947938", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41375-021-01257-7"}], "notes": [], "created": "2021-05-06T05:52:53.609Z", "modified": "2021-05-06T05:52:53.635Z"}, {"entity": "publication", "iuid": "c60e9460c17a4c23a2bc424aa1029baa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c60e9460c17a4c23a2bc424aa1029baa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c60e9460c17a4c23a2bc424aa1029baa"}}, "title": "Multi-omics reveals age-related differences in the diaphragm response to mechanical ventilation: a pilot study.", "authors": [{"family": "Lyu", "given": "Qiong", "initials": "Q"}, {"family": "Wen", "given": "Ya", "initials": "Y"}, {"family": "Zhang", "given": "Xiang", "initials": "X"}, {"family": "Addinsall", "given": "Alex B", "initials": "AB"}, {"family": "Cacciani", "given": "Nicola", "initials": "N"}, {"family": "Larsson", "given": "Lars", "initials": "L", "orcid": "0000-0003-3722-035X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5f02065531945db928529767189a083.json"}}], "type": "comparative study", "published": "2021-05-03", "journal": {"title": "Skeletal Muscle", "issn": "2044-5040", "issn-l": null, "volume": "11", "issue": "1", "pages": "11"}, "abstract": "Old age is associated with a significantly increased mortality in COVID-19 patients exposed to long-term controlled mechanical ventilation (CMV) and suggested to be due to the hyperinflammatory response associated with the viral infection. However, our understanding of age-related differences in the response to CMV in the absence of a viral infection remains insufficient.\n\nYoung (7-8 months) and old (28-32 months) F344 BN hybrid rats were exposed to the ICU condition for 5 days, i.e., complete immobilization, mechanical ventilation, and extensive monitoring. Transcriptomic (RNA-Seq) and proteomics (Proximity Extension Assay) analyses of the diaphragm and proteomics analysis of plasma were conducted to investigate the molecular differences between young and old rats exposed to the ICU condition.\n\nAccording to multi-omics analyses, significant differences were observed in the diaphragm between young and old rats in response to 5 days CMV and immobilization. In young rats, metabolic pathways were primarily downregulated in response to immobilization (post-synaptic blockade of neuromuscular transmission). In old rats, on the other hand, dramatic immune and inflammatory responses were observed, i.e., an upregulation of specific related pathways such as \"IL-17 signaling pathway\", along with a higher level of inflammatory factors and cytokine/chemokine in plasma.\n\nThe dramatically increased mortality in old ICU patients with COVID-19-associated hyperinflammation and cytokine storm need not only reflect the viral infection but may also be associated with the ventilator induced diaphragm dysfunction (VIDD) and hyperinflammatory responses induced by long-term CMV per se. Although mechanical ventilation is a life-saving intervention in COVID-19 ICU patients, CMV should be cautiously used especially in old age and other means of respiratory support may be considered, such as negative pressure ventilation.", "doi": "10.1186/s13395-021-00267-4", "pmid": "33941271", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13395-021-00267-4"}, {"db": "pmc", "key": "PMC8089133"}], "notes": [], "created": "2021-05-04T15:55:44.955Z", "modified": "2021-06-10T11:24:48.982Z"}, {"entity": "publication", "iuid": "d1f06bd2922e4bbbbedc6a1fd11f2401", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1f06bd2922e4bbbbedc6a1fd11f2401.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1f06bd2922e4bbbbedc6a1fd11f2401"}}, "title": "Knowledge and preventive behaviors regarding COVID-19 in Bangladesh: A nationwide distribution", "authors": [{"family": "Hosen", "given": "Ismail", "initials": "I"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Sakib", "given": "Najmuj", "initials": "N"}, {"family": "Hussain", "given": "Nur", "initials": "N"}, {"family": "al Mamun", "given": "Firoj", "initials": "F"}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA"}], "type": "journal-article", "published": "2021-05-03", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "5", "pages": "e0251151"}, "abstract": null, "doi": "10.1371/journal.pone.0251151", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.7910/DVN/YKH9C1", "description": "Dataset: socio-demographic characteristics,  sources from where participants get information regarding COVID-19, participants\u2019 knowledge concerning COVID-19, participants\u2019 behavior in preventing COVID-19 etc."}], "notes": [], "created": "2021-05-04T15:56:57.740Z", "modified": "2021-07-14T08:38:09.031Z"}, {"entity": "publication", "iuid": "8cdc3bccc3c8411e8e40b47d294ea43a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8cdc3bccc3c8411e8e40b47d294ea43a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8cdc3bccc3c8411e8e40b47d294ea43a"}}, "title": "False Positive Results in SARS-CoV-2 Serological Tests for Samples From Patients With Chronic Inflammatory Diseases", "authors": [{"family": "Kharlamova", "given": "Nastya", "initials": "N"}, {"family": "Dunn", "given": "Nicky", "initials": "N"}, {"family": "Bedri", "given": "Sahl K", "initials": "SK"}, {"family": "Jerling", "given": "Svante", "initials": "S"}, {"family": "Almgren", "given": "Malin", "initials": "M"}, {"family": "Faustini", "given": "Francesca", "initials": "F"}, {"family": "Gunnarsson", "given": "Iva", "initials": "I"}, {"family": "R\u00f6nnelid", "given": "Johan", "initials": "J"}, {"family": "Pullerits", "given": "Rille", "initials": "R"}, {"family": "Gjertsson", "given": "Inger", "initials": "I"}, {"family": "Lundberg", "given": "Karin", "initials": "K"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Fink", "given": "Katharina", "initials": "K"}, {"family": "Fogdell-Hahn", "given": "Anna", "initials": "A"}], "type": "journal-article", "published": "2021-05-03", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "12", "issue": null, "pages": "666114"}, "abstract": "Patients with chronic inflammatory diseases are often treated with immunosuppressants and therefore are of particular concern during the SARS-CoV-2 pandemic. Serological tests will improve our understanding of the infection and immunity in this population, unless they tests give false positive results. The aim of this study was to evaluate the specificity of SARS-Cov-2 serological assays using samples from patients with chronic inflammatory diseases collected prior to April 2019, thus defined as negative. Samples from patients with multiple sclerosis (MS, n=10), rheumatoid arthritis (RA, n=47) with or without rheumatoid factor (RF) and/or anti-cyclic citrullinated peptide antibodies (anti-CCP2) and systemic lupus erythematosus (SLE, n=10) with or without RF, were analyzed for SARS-CoV-2 antibodies using 17 commercially available lateral flow assays (LFA), two ELISA kits and one in-house developed IgG multiplex bead-based assay. Six LFA and the in-house validated IgG assay correctly produced negative results for all samples. However, the majority of assays (n=13), gave false positive signal for samples from patients with RA and SLE. This was most notable in samples from RF positive RA patients. No false positive samples were detected in any assay using samples from patients with MS. Poor specificity of commercial serological assays could possibly be, at least partly, due to interfering antibodies in samples from patients with chronic inflammatory diseases. For these patients, the risk of false positivity should be considered when interpreting results of the SARS-CoV-2 serological assays.", "doi": "10.3389/fimmu.2021.666114", "pmid": "34012450", "labels": {"Type: Journal article": null, "Funder: Vinnova": null, "Category: Serology": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8126683"}, {"db": "URL", "key": "https://doi.org/10.3389/fimmu.2021.666114.s001", "description": "False Positive Results in SARS-CoV-2 Serological Tests for Samples From Patients With Chronic Inflammatory Diseases"}], "notes": [], "created": "2021-05-21T17:22:04.614Z", "modified": "2021-11-19T11:29:29.703Z"}, {"entity": "publication", "iuid": "9f36b274935a454b82985f1686c1cf90", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f36b274935a454b82985f1686c1cf90.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f36b274935a454b82985f1686c1cf90"}}, "title": "COVID-19 and ANCA-associated vasculitis \u2013 recommendations for vaccine preparedness and the use of rituximab", "authors": [{"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Alberici", "given": "Federico", "initials": "F"}, {"family": "Fervenza", "given": "Fernando C", "initials": "FC"}, {"family": "Jayne", "given": "David R W", "initials": "DRW"}, {"family": "Segelmark", "given": "M\u00e5rten", "initials": "M"}, {"family": "Tesar", "given": "Vladimir", "initials": "V"}, {"family": "Szpirt", "given": "Wladimir M", "initials": "WM"}], "type": "journal-article", "published": "2021-05-03", "journal": {"title": "Nephrol Dial Transplant", "issn": "0931-0509", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1093/ndt/gfab174", "pmid": null, "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-05T05:25:35.500Z", "modified": "2021-05-05T05:25:35.513Z"}, {"entity": "publication", "iuid": "1dd2c1d420b74b8c96ee17f2ba351e6c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1dd2c1d420b74b8c96ee17f2ba351e6c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1dd2c1d420b74b8c96ee17f2ba351e6c"}}, "title": "A urinary peptidomic profile predicts outcome in SARS-CoV-2-infected patients.", "authors": [{"family": "Wendt", "given": "Ralph", "initials": "R"}, {"family": "Thijs", "given": "Lutgarde", "initials": "L"}, {"family": "Kalbitz", "given": "Sven", "initials": "S"}, {"family": "Mischak", "given": "Harald", "initials": "H"}, {"family": "Siwy", "given": "Justyna", "initials": "J"}, {"family": "Raad", "given": "Julia", "initials": "J"}, {"family": "Metzger", "given": "Jochen", "initials": "J"}, {"family": "Neuhaus", "given": "Barbara", "initials": "B"}, {"family": "Leyen", "given": "Heiko von der", "initials": "HV"}, {"family": "Dudoignon", "given": "Emmanuel", "initials": "E"}, {"family": "Mebazaa", "given": "Alexandre", "initials": "A"}, {"family": "Spasovski", "given": "Goce", "initials": "G"}, {"family": "Milenkova", "given": "Mimoza", "initials": "M"}, {"family": "Canevska-Talevska", "given": "Aleksandra", "initials": "A"}, {"family": "Czerwie\u0144ska", "given": "Beata", "initials": "B"}, {"family": "Wiecek", "given": "Andrzej", "initials": "A"}, {"family": "Peters", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Nilsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Schwab", "given": "Matthias", "initials": "M"}, {"family": "Rothfuss", "given": "Katja", "initials": "K"}, {"family": "L\u00fcbbert", "given": "Christoph", "initials": "C"}, {"family": "Staessen", "given": "Jan A", "initials": "JA"}, {"family": "Beige", "given": "Joachim", "initials": "J"}, {"family": "CRIT-COV-U investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-03", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": null, "issue": null, "pages": "100883", "issn-l": null}, "abstract": "COVID-19 prediction models based on clinical characteristics, routine biochemistry and imaging, have been developed, but little is known on proteomic markers reflecting the molecular pathophysiology of disease progression.\n\nhe multicentre (six European study sites) Prospective Validation of a Proteomic Urine Test for Early and Accurate Prognosis of Critical Course Complications in Patients with SARS-CoV-2 Infection Study (Crit-COV-U) is recruiting consecutive patients (\u2265 18 years) with PCR-confirmed SARS-CoV-2 infection. A urinary proteomic biomarker (COV50) developed by capillary-electrophoresis-mass spectrometry (CE-MS) technology, comprising 50 sequenced peptides and identifying the parental proteins, was evaluated in 228 patients (derivation cohort) with replication in 99 patients (validation cohort). Death and progression along the World Health Organization (WHO) Clinical Progression Scale were assessed up to 21 days after the initial PCR test. Statistical methods included logistic regression, receiver operating curve (ROC) analysis and comparison of the area under the curve (AUC).\n\nin the derivation cohort, 23 patients died, and 48 developed worse WHO scores. The odds ratios (OR) for death per 1 standard deviation (SD) increment in COV50 were 3\u00b752 (95% CI, 2\u00b702-6\u00b713, p <0\u00b70001) unadjusted and 2\u00b773 (1\u00b725-5\u00b795, p = 0\u00b7012) adjusted for sex, age, baseline WHO score, body mass index (BMI) and comorbidities. For WHO scale progression, the corresponding OR were 2\u00b763 (1\u00b780-3\u00b785, p<0\u00b70001) and 3\u00b738 (1\u00b785-6\u00b717, p<0\u00b70001), respectively. The area under the curve (AUC) for COV50 as a continuously distributed variable was 0\u00b780 (0\u00b772-0\u00b788) for mortality and 0\u00b774 (0\u00b766-0\u00b781) for worsening WHO score. The optimised COV50 thresholds for mortality and worsening WHO score were 0\u00b747 and 0\u00b704 with sensitivity/specificity of 87\u00b70 (74\u00b76%) and 77\u00b71 (63\u00b79%), respectively. On top of covariates, COV50 improved the AUC, albeit borderline for death, from 0\u00b778 to 0\u00b782 (p = 0\u00b711) and 0\u00b784 (p = 0\u00b7052) for mortality and from 0\u00b768 to 0\u00b778 (p = 0\u00b70097) and 0\u00b775 (p = 0\u00b7021) for worsening WHO score. The validation cohort findings were confirmatory.\n\nthis first CRIT-COV-U report proves the concept that urinary proteomic profiling generates biomarkers indicating adverse COVID-19 outcomes, even at an early disease stage, including WHO stages 1-3. These findings need to be consolidated in an upcoming final dataset.", "doi": "10.1016/j.eclinm.2021.100883", "pmid": "33969282", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(21)00163-2"}, {"db": "pmc", "key": "PMC8092440"}], "notes": [], "created": "2021-05-17T18:39:24.579Z", "modified": "2021-05-17T19:02:55.993Z"}, {"entity": "publication", "iuid": "f7ab08cba0a74716b976aaa57be82009", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7ab08cba0a74716b976aaa57be82009.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7ab08cba0a74716b976aaa57be82009"}}, "title": "Recent advances on smart glycoconjugate vaccines in infections and cancer.", "authors": [{"family": "Anderluh", "given": "Marko", "initials": "M"}, {"family": "Berti", "given": "Francesco", "initials": "F"}, {"family": "Bzducha-Wr\u00f3bel", "given": "Anna", "initials": "A"}, {"family": "Chiodo", "given": "Fabrizio", "initials": "F"}, {"family": "Colombo", "given": "Cinzia", "initials": "C"}, {"family": "Compostella", "given": "Federica", "initials": "F"}, {"family": "Durlik", "given": "Katarzyna", "initials": "K"}, {"family": "Ferhati", "given": "Xhenti", "initials": "X"}, {"family": "Holmdahl", "given": "Rikard", "initials": "R"}, {"family": "Jovanovic", "given": "Dragana", "initials": "D"}, {"family": "Kaca", "given": "Wieslaw", "initials": "W"}, {"family": "Lay", "given": "Luigi", "initials": "L"}, {"family": "Marinovic-Cincovic", "given": "Milena", "initials": "M"}, {"family": "Marradi", "given": "Marco", "initials": "M"}, {"family": "Ozil", "given": "Musa", "initials": "M"}, {"family": "Polito", "given": "Laura", "initials": "L"}, {"family": "Reina", "given": "Jos\u00e8 Juan", "initials": "JJ"}, {"family": "Reis", "given": "Celso A", "initials": "CA"}, {"family": "Sackstein", "given": "Robert", "initials": "R"}, {"family": "Silipo", "given": "Alba", "initials": "A"}, {"family": "\u0160vajger", "given": "Urban", "initials": "U"}, {"family": "Van\u011bk", "given": "Ond\u0159ej", "initials": "O"}, {"family": "Yamamoto", "given": "Fumiichiro", "initials": "F"}, {"family": "Richichi", "given": "Barbara", "initials": "B"}, {"family": "van Vliet", "given": "Sandra J", "initials": "SJ"}], "type": "journal article", "published": "2021-05-02", "journal": {"title": "FEBS J", "issn": "1742-4658", "volume": null, "issue": null, "issn-l": null}, "abstract": "Vaccination is one of the greatest achievements in biomedical research preventing death and morbidity in many infectious diseases through the induction of pathogen-specific humoral and cellular immune responses. Currently, no effective vaccines are available for pathogens with a highly variable antigenic load, such as the Human Immunodeficiency Virus or to induce cellular T cell immunity in the fight against cancer. The recent SARS-CoV-2 outbreak has reinforced the relevance of designing smart therapeutic vaccine modalities to ensure public health. Indeed, academic and private companies have ongoing joint efforts to develop novel vaccine prototypes for this virus. Many pathogens are covered by a dense glycan-coat, which form an attractive target for vaccine development. Moreover, many tumor types are characterized by altered glycosylation profiles that are known as 'tumor-associated carbohydrate antigens' (TACA). Unfortunately, glycans do not provoke a vigorous immune response and generally serve as T cell-independent antigens, not eliciting protective IgG responses nor inducing immunological memory. A close and continuous crosstalk between glycochemists and glycoimmunologists is essential for the successful development of efficient immune modulators. It is clear that this is a key point for the discovery of novel approaches, which could significantly improve our understanding of the immune system. In this review, we discuss the latest advancements in development of vaccines against glycan epitopes to gain selective immune responses, and to provide an overview on the role of different immunogenic constructs in improving glycovaccine efficacy.", "doi": "10.1111/febs.15909", "pmid": "33934527", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-05-04T16:00:22.998Z", "modified": "2021-05-04T16:00:37.238Z"}, {"entity": "publication", "iuid": "72366a5fda114992bd1bbdfa17219211", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/72366a5fda114992bd1bbdfa17219211.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/72366a5fda114992bd1bbdfa17219211"}}, "title": "Hypercoagulation detected by Rotational Thromboelastometry predicts mortality in COVID-19: A risk model based on a prospective observational study.", "authors": [{"family": "Almskog", "given": "Lou M", "initials": "LM"}, {"family": "Wikman", "given": "Agneta", "initials": "A"}, {"family": "Svensson", "given": "Jonas", "initials": "J"}, {"family": "Bottai", "given": "Matteo", "initials": "M"}, {"family": "Kotorman", "given": "Mariann", "initials": "M"}, {"family": "Wahlgren", "given": "Carl Magnus", "initials": "CM"}, {"family": "Wanecek", "given": "Michael", "initials": "M"}, {"family": "van der Linden", "given": "Jan", "initials": "J"}, {"family": "Agren", "given": "Anna", "initials": "A"}], "type": "posted-content", "published": "2021-05-02", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.29.21256241", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-06T05:55:09.580Z", "modified": "2021-05-29T16:36:11.743Z"}, {"entity": "publication", "iuid": "63be2794a8004e448f9fdca621b953b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63be2794a8004e448f9fdca621b953b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63be2794a8004e448f9fdca621b953b0"}}, "title": "Aspirin and NSAID use and the risk of COVID-19", "authors": [{"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Guo", "given": "Chuan Guo", "initials": "CG"}, {"family": "Lee", "given": "Karla A", "initials": "KA"}, {"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Lo", "given": "Chun Han", "initials": "CH"}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Mehta", "given": "Raaj S", "initials": "RS"}, {"family": "Kwon", "given": "Sohee", "initials": "S"}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Song", "given": "Mingyang", "initials": "M"}, {"family": "Davies", "given": "Richard", "initials": "R"}, {"family": "Capdevila", "given": "Joan", "initials": "J"}, {"family": "Lochlainn", "given": "Mary Ni", "initials": "MN"}, {"family": "Sudre", "given": "Carole H", "initials": "CH", "orcid": "0000-0001-5753-428X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c26472813fed4007a8757af771de1802.json"}}, {"family": "Graham", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-4170-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f5f4e19812a46ed9e873732ec25e28d.json"}}, {"family": "Varsavsky", "given": "Thomas", "initials": "T"}, {"family": "Gomez", "given": "Maria F", "initials": "MF"}, {"family": "Kennedy", "given": "Beatrice", "initials": "B"}, {"family": "Fitipaldi", "given": "Hugo", "initials": "H"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Spector", "given": "Tim D", "initials": "TD"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S", "orcid": "0000-0002-5694-5340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74c7b9b1633144879042d198c7205656.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}], "type": "posted-content", "published": "2021-05-02", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.28.21256261", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "Health data research innovation gateway", "key": "https://healthdatagateway.org/detail/9b604483-9cdc-41b2-b82c-14ee3dd705f6", "description": "Anonymized data is available to be shared with bonafide researchers HDRUK according to their protocols"}, {"db": "ZOE covid study", "key": "https://covid.joinzoe.com", "description": "Data updates for covid study"}], "notes": [], "created": "2021-05-06T05:56:52.220Z", "modified": "2023-06-19T15:28:02.337Z"}, {"entity": "publication", "iuid": "070bbe0d37c84be0a2e31eeff5e35c3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/070bbe0d37c84be0a2e31eeff5e35c3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/070bbe0d37c84be0a2e31eeff5e35c3d"}}, "title": "Therapeutic plasma exchange (TPE) as a plausible rescue therapy in severe vaccine-induced immune thrombotic thrombocytopenia", "authors": [{"family": "Rock", "given": "Gail", "initials": "G"}, {"family": "Weber", "given": "Viktoria", "initials": "V"}, {"family": "Stegmayr", "given": "Bernd", "initials": "B"}], "type": "journal-article", "published": "2021-05-00", "journal": {"title": "Transfusion and Apheresis Science", "issn": "1473-0502", "issn-l": null, "volume": null, "issue": null, "pages": "103174"}, "abstract": null, "doi": "10.1016/j.transci.2021.103174", "pmid": null, "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-06-08T08:43:34.819Z", "modified": "2021-06-08T08:43:48.285Z"}, {"entity": "publication", "iuid": "44a461149ac34464b639e5263b01da57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44a461149ac34464b639e5263b01da57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44a461149ac34464b639e5263b01da57"}}, "title": "Stigma, Trust, and procedural integrity: Covid-19 testing in Malawi.", "authors": [{"family": "Ferree", "given": "Karen E", "initials": "KE"}, {"family": "Harris", "given": "Adam S", "initials": "AS"}, {"family": "Dulani", "given": "Boniface", "initials": "B"}, {"family": "Kao", "given": "Kristen", "initials": "K"}, {"family": "Lust", "given": "Ellen", "initials": "E"}, {"family": "Metheney", "given": "Erica", "initials": "E"}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "World Dev", "issn": "0305-750X", "volume": "141", "issue": null, "pages": "105351", "issn-l": null}, "abstract": "An emerging consensus in public health views testing for Covid-19 as key to managing the pandemic. It is often assumed that citizens have a strong desire to know their Covid-19 status, and will therefore take advantage of testing opportunities. This may not be the case in all contexts, however, especially those where citizens perceive stigma associated with the Covid-19, have low trust in health institutions, and doubt the procedural integrity of the testing process. This article explores willingness to receive a free Covid-19 test via a vignette experiment (conjoint design) embedded in a phone survey conducted in Malawi in May 2020. The experiment varied test provider (public clinic versus international health organization), proximity to illness, and reassurance of confidentiality. We find that Malawians expect higher uptake of testing in their community when the international health organization offered the test rather than a public clinic, an effect we attribute to higher trust in the organization and/or perceptions of greater capacity to ensure procedural integrity. The confidentiality reassurance did not substantially alter beliefs about the privacy of results, but did increase doubts about the willingness of community members to get tested in a public health clinic. Our findings suggest the importance of considering the demand side of testing in addition to well-known challenges of supply.", "doi": "10.1016/j.worlddev.2020.105351", "pmid": "33456104", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0305-750X(20)30479-4"}, {"db": "pmc", "key": "PMC7803152"}], "notes": [], "created": "2021-03-06T10:23:01.391Z", "modified": "2021-03-06T10:23:01.404Z"}, {"entity": "publication", "iuid": "275782e9e32446cea2ff723ecad7d2e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/275782e9e32446cea2ff723ecad7d2e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/275782e9e32446cea2ff723ecad7d2e2"}}, "title": "Role of the SphK-S1P-S1PRs pathway in invasion of the nervous system by SARS-CoV-2 infection.", "authors": [{"family": "Pan", "given": "Yuehai", "initials": "Y"}, {"family": "Gao", "given": "Fei", "initials": "F"}, {"family": "Zhao", "given": "Shuai", "initials": "S"}, {"family": "Han", "given": "Jinming", "initials": "J"}, {"family": "Chen", "given": "Fan", "initials": "F"}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Clin Exp Pharmacol Physiol", "issn": "0305-1870", "volume": "48", "issue": "5", "pages": "637-650", "issn-l": null}, "abstract": "Global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still ongoing. Before an effective vaccine is available, the development of potential treatments for resultant coronavirus disease 2019 (COVID-19) is crucial. One of the disease hallmarks is hyper-inflammatory responses, which usually leads to a severe lung disease. Patients with COVID-19 also frequently suffer from neurological symptoms such as acute diffuse encephalomyelitis, brain injury and psychiatric complications. The metabolic pathway of sphingosine-1-phosphate (S1P) is a dynamic regulator of various cell types and disease processes, including the nervous system. It has been demonstrated that S1P and its metabolic enzymes, regulating neuroinflammation and neurogenesis, exhibit important functions during viral infection. S1P receptor 1 (S1PR1) analogues including AAL-R and RP-002 inhibit pathophysiological responses at the early stage of H1N1 virus infection and then play a protective role. Fingolimod (FTY720) is an S1P receptor modulator and is being tested for treating COVID-19. Our review provides an overview of SARS-CoV-2 infection and critical role of the SphK-S1P-SIPR pathway in invasion of SARS-CoV-2 infection, particularly in the central nervous system (CNS). This may help design therapeutic strategies based on the S1P-mediated signal transduction, and the adjuvant therapeutic effects of S1P analogues to limit or prevent the interaction between the host and SARS-CoV-2, block the spread of the SARS-CoV-2, and consequently treat related complications in the CNS.", "doi": "10.1111/1440-1681.13483", "pmid": "33565127", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8014301"}], "notes": [], "created": "2021-02-10T18:59:44.359Z", "modified": "2021-07-14T07:52:09.600Z"}, {"entity": "publication", "iuid": "a5b6512797d7493d89230b70f9d0b4a3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a5b6512797d7493d89230b70f9d0b4a3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a5b6512797d7493d89230b70f9d0b4a3"}}, "title": "Residual antimicrobial agents in food originating from animals.", "authors": [{"family": "Hassan", "given": "Mohammad Mahmudul", "initials": "MM"}, {"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}, {"family": "Khan Nayem", "given": "Md Raihan", "initials": "MR"}, {"family": "Tanzin", "given": "Abu Zubayer", "initials": "AZ"}, {"family": "Badsha", "given": "Md Rahim", "initials": "MR"}, {"family": "Khan", "given": "Shahneaz Ali", "initials": "SA"}, {"family": "Ashour", "given": "Hossam M", "initials": "HM"}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Trends Food Sci Technol", "issn": "0924-2244", "volume": "111", "issue": null, "pages": "141-150", "issn-l": null}, "abstract": "The agricultural food products industry in Bangladesh depends on utilizing antimicrobials indiscriminately as growth promoters and for controlling infectious diseases. Thus, there is always a risk of antimicrobial agent accumulation in food sources that originate from agricultural production.\n\nIn the present study, we collected data from published articles between January, 2013 and December, 2019 on antimicrobial residues in human food sources such as meat, milk, eggs, and fishes.\n\nLiver contained the highest percentage of antimicrobial residues (74%; 95% CI: 59.66-85.37) against the invitro enteric pathogen Escherichia coli in layer chickens. Similar results were demonstrated in liver (68%; 95% CI: 53.30-80.48) and kidney (66%, 95% CI: 51.23-78.79) of layer chickens against Bacillus cereus and Bacillus subtilis. Amongst all antibiotics, the highest concentrations of ciprofloxacin were detected in kidney (48.57%; 95% CI: 31.38-66.01), followed by liver (47.56; 95% CI: 40.88-54.30) of broiler chickens. Ciprofloxacin was also present in liver (46.15%; 95% CI: 33.70-58.96) of layer chickens. The percentage of ciprofloxacin in thigh and breast meat in broiler bird were 41.54% (95% CI: 34.54-48.79) and 37.95% (95% CI: 31.11-45.15) respectively. Enrofloxacin was the second most dominant antimicrobial agent and was present in the liver of both types of poultry (Broiler and Layer chickens: 41.54%; 95% CI: 29.44-54.4 and 437.33%; 95% CI: 30.99-44.01). The prevalence rates of enrofloxacin in thigh and breast meat of broiler chickens were 24.10% (95% CI: 18.28-30.73) and 20.51% (95% CI: 15.08-26.87), respectively. Tetracycline, a commonly used antibiotic in livestock, was present in the liver (49.23%; 95% CI: 36.60-61.93) of layer chickens. In case of aquaculture food products, the highest amount of amoxicillin (683.2 mg/kg) was detected in Tilapia fish (Oreochromis niloticus), followed by 584.4 mg/kg in climbing perch (Anabas testudineus) and 555.6 mg/kg in Rui fish (Labeo rohita). Among the five types of fishes, Rui fish (0.000515 mg/kg) contained the highest concentrations of chloramphenicol antibiotic residues.\n\nThe presence of antimicrobial residues in meat, milk, egg, and fish is a serious public health threat due to the potential induction of antimicrobial resistance. It can negatively impact the food supply chain, especially with the current strain that it is already facing with the current COVID-19 pandemic. The findings of the present study highlight the ongoing risk of residual antimicrobial agents in food of animal origin in Bangladesh and countries with similar practices. This can draw the attention of public health officials to propose plans to mitigate or stop this practice.", "doi": "10.1016/j.tifs.2021.01.075", "pmid": "33746363", "labels": {"Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0924-2244(21)00083-2"}, {"db": "pmc", "key": "PMC7953985"}], "notes": [], "created": "2021-03-29T14:16:29.522Z", "modified": "2021-03-29T14:16:29.545Z"}, {"entity": "publication", "iuid": "a669fe2e8b544fad8541143ddb165f62", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a669fe2e8b544fad8541143ddb165f62.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a669fe2e8b544fad8541143ddb165f62"}}, "title": "Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of COVID-19 death.", "authors": [{"family": "Szekely", "given": "Laszlo", "initials": "L", "orcid": "0000-0001-6144-6573", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/906008558d5c4734bb28388154759186.json"}}, {"family": "Bozoky", "given": "Bela", "initials": "B"}, {"family": "Bendek", "given": "Matyas", "initials": "M"}, {"family": "Ostad", "given": "Masih", "initials": "M"}, {"family": "Lavignasse", "given": "Pablo", "initials": "P"}, {"family": "Haag", "given": "Lars", "initials": "L", "orcid": "0000-0002-9268-0562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fd8deb7580e4371901510e07ca478ab.json"}}, {"family": "Wu", "given": "Jieyu", "initials": "J", "orcid": "0000-0002-7063-6990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3c151e3e7ed4d3f81fbfc398e7828ce.json"}}, {"family": "Jing", "given": "Xu", "initials": "X"}, {"family": "Gupta", "given": "Soham", "initials": "S"}, {"family": "Saccon", "given": "Elisa", "initials": "E", "orcid": "0000-0003-3283-4432", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28cbb3510cbc4bf5b4db2bee1689467f.json"}}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Cao", "given": "Yihai", "initials": "Y"}, {"family": "Bj\u00f6rnstedt", "given": "Mikael", "initials": "M"}, {"family": "Szakos", "given": "Attila", "initials": "A"}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "issn-l": null, "volume": "7", "issue": "5", "pages": "e07134"}, "abstract": "Most COVID-19 victims are old and die from unrelated causes. Here we present twelve complete autopsies, including two rapid autopsies of young patients where the cause of death was COVID-19 ARDS. The main virus induced pathology was in the lung parenchyma and not in the airways. Most coagulation events occurred in the intra-alveolar and not in the intra-vascular space and the few thrombi were mainly composed of aggregated thrombocytes. The dominant inflammatory response was the massive accumulation of CD163 + macrophages and the disappearance of T killer, NK and B-cells. The virus was replicating in the pneumocytes and macrophages but not in bronchial epithelium, endothelium, pericytes or stromal cells. The lung consolidations were produced by a massive regenerative response, stromal and epithelial proliferation and neovascularization. We suggest that thrombocyte aggregation inhibition, angiogenesis inhibition and general proliferation inhibition may have a roll in the treatment of advanced COVID-19 ARDS.", "doi": "10.1016/j.heliyon.2021.e07134", "pmid": "34056141", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC8141733"}, {"db": "pii", "key": "S2405-8440(21)01237-8"}], "notes": [], "created": "2021-06-02T13:16:12.980Z", "modified": "2023-06-19T14:35:28.386Z"}, {"entity": "publication", "iuid": "86d82d91b8c742a4b1f99b3b3e91e1e3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86d82d91b8c742a4b1f99b3b3e91e1e3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86d82d91b8c742a4b1f99b3b3e91e1e3"}}, "title": "Nitric oxide and COVID\u201019: Dose, timing and how to administer it might be crucial", "authors": [{"family": "Frostell", "given": "Claes G", "initials": "CG", "orcid": "0000-0002-7199-1310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874beab519f143db8659a7936aa46142.json"}}, {"family": "Hedenstierna", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0002-2923-6012", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cee3c79aa318422ba4bcfceeb5f5e44c.json"}}], "type": "journal-article", "published": "2021-05-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "0001-5172", "volume": "65", "issue": "5", "pages": "576-577", "issn-l": null}, "abstract": "Nitric oxide (NO) for inhalation has been a clinical option in the ICU since the early 1990s. Much has been written and claimed after the initial enthusiasm over an acutely improved arterial oxygenation in adult patients with ARDS. A few years ago, a meta-analysis (1) concluded that the regular use of inhaled NO (iNO) in patients with ARDS outside a clinical trial could not be recommended, as no benefit such as reduced mortality or time on the ventilator could be identified in published randomized studies.", "doi": "10.1111/aas.13788", "pmid": "33533477", "labels": {"Type: Other": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-04T18:11:58.380Z", "modified": "2021-06-18T11:22:27.514Z"}, {"entity": "publication", "iuid": "50767935110245d6b5ce53ca33f247c3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50767935110245d6b5ce53ca33f247c3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50767935110245d6b5ce53ca33f247c3"}}, "title": "Mortality trends among hospitalised COVID-19 patients in Sweden: A nationwide observational cohort study", "authors": [{"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-8801-3169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37509c3832244b019b91a1fe2cbe183e.json"}}, {"family": "Wahlstr\u00f6m", "given": "Erik", "initials": "E", "orcid": "0000-0002-0800-8520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f623177f84a4f4ba85571b106e4cec5.json"}}, {"family": "Walther", "given": "Sten", "initials": "S"}, {"family": "Bennet-Bark", "given": "Anna M", "initials": "AM"}, {"family": "Heurgren", "given": "Mona", "initials": "M"}, {"family": "Lind\u00e9n", "given": "Thomas", "initials": "T"}, {"family": "Holm", "given": "Johanna", "initials": "J", "orcid": "0000-0002-0220-3288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33faae9af4924abdb8f29a6abf0d2f2a.json"}}, {"family": "Hanberger", "given": "H\u00e5kan", "initials": "H", "orcid": "0000-0002-4199-0229", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ccccceb630874fc5ab7507a313b59039.json"}}], "type": "journal-article", "published": "2021-05-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "4", "issue": null, "pages": "100054", "issn-l": null}, "abstract": "It is important to know if mortality among hospitalised COVID-19 patients has changed as the pandemic has progressed. The aim of this study was to describe the dynamics over time of mortality among patients hospitalised for COVID-19 in Sweden, using nationwide data compiled by the Swedish National Board of Health and Welfare.\n\nObservational cohort study where all patients hospitalised in Sweden between March 1 and September 30, 2020, with SARS-CoV-2 RNA positivity 14 days before to 5 days after admission and a discharge code for COVID-19 were included. Outcome was 60-day all-cause mortality. Patients were categorised according to month of hospital admission. Poisson regression was used to estimate the relative risk of death by month of admission, adjusting for, age, sex, comorbidities, care dependency, country of birth, healthcare region, and Simplified Acute Physiology, version 3 (patients in intensive care units; ICU).\n\nA total of 17,140 patients were included, of which 2943 died within 60 days of admission. The overall 60-day mortality was thus 17\u00b72% (95% CI, 16\u00b76%-17\u00b77%), and it decreased from 24\u00b77% (95% CI, 23\u00b70%-26\u00b75%) in March to 10\u00b74% (95% CI, 8\u00b79%-12\u00b71%) post-wave (July-September). Adjusted relative risk (RR) of death was 0\u00b746 (95% CI, 0\u00b739-0\u00b754) post-wave, using March as reference. Corresponding RR for patients not admitted to ICU and those admitted to ICU were 0\u00b749 (95% CI, 0\u00b742-0\u00b759) and 0\u00b749 (95% CI, 0\u00b733-0\u00b772), respectively. The proportion of patients admitted to ICU decreased from 19\u00b74% (95% CI, 17\u00b79%-21\u00b71%) in the March cohort to 8\u00b79% (95% CI, 7\u00b75%-10\u00b76%) post-wave.\n\nThere was a gradual decline in mortality during the spring of 2020 in Swedish hospitalised COVID-19 patients, independent of baseline patient characteristics. Future research is needed to explain the reasons for this decline. The changing COVID-19 mortality should be taken into account when management and results of studies from the first pandemic wave are evaluated.\n\nThis study was funded by Sweden's National Board of Health and Welfare.", "doi": "10.1016/j.lanepe.2021.100054", "pmid": "33997829", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00031-4"}, {"db": "pmc", "key": "PMC7907732"}], "notes": [], "created": "2021-05-21T17:00:23.534Z", "modified": "2022-11-21T15:34:05.650Z"}, {"entity": "publication", "iuid": "9b66926507624c89bdbb6a379fc5f0d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b66926507624c89bdbb6a379fc5f0d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b66926507624c89bdbb6a379fc5f0d5"}}, "title": "Lockdown Measures Which Reduced Greenhouse Gas Emissions With Little Negative Impact on Quality of Life.", "authors": [{"family": "Niemi", "given": "Maria", "initials": "M", "orcid": "0000-0001-5407-6981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/335195cc925f4f438775330e3a1f5a8e.json"}}, {"family": "Skelton", "given": "Alasdair", "initials": "A", "orcid": "0000-0002-3732-7993", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1be6eb7f00b14da890385f496318bf7a.json"}}, {"family": "Noone", "given": "Kevin", "initials": "K", "orcid": "0000-0001-7095-7412", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e045eacf18242a2a27a31f1b56738dd.json"}}, {"family": "Olsson", "given": "Mats J", "initials": "MJ", "orcid": "0000-0001-5592-3759", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cdd692617b7d475dba4532b2d28a8cc6.json"}}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Earths Future", "issn": "2328-4277", "volume": "9", "issue": "5", "pages": "e2020EF001909", "issn-l": null}, "abstract": "Lockdown measures in response to the new Covid-19 virus have caused the largest ever fall of annual greenhouse gas emissions. A key question that we attempt to answer in this study is which, if any, of these measures can be productively encouraged post-lockdown in efforts to sustain at least part of this reduction in emissions. Sweden is uniquely suited for our study because the voluntary nature of lockdown in Sweden allowed us to assess the level of compliance to recommendations and its effects on greenhouse gas emissions. First, we assessed the change of perceived quality of life (QOL) among 746 individuals from Stockholm region due to adhering to lockdown measures. Second, we calculated the associated change of annual per capita greenhouse emissions. We found that avoiding travel for work, avoiding purchasing, and avoiding restaurants had the least negative effect on QOL, and at the same time the largest positive effect on carbon dioxide equivalent (CO2e) emission reductions. We conclude that these are potential leverage points for stimulating behavioral change that has a positive climatic impact.", "doi": "10.1029/2020EF001909", "pmid": "34230885", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "EFT2794"}, {"db": "pmc", "key": "PMC8250258"}], "notes": [], "created": "2021-08-06T08:34:07.410Z", "modified": "2021-08-06T08:34:07.531Z"}, {"entity": "publication", "iuid": "1bd81d0ffef846729bedaa9804f6fdd1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1bd81d0ffef846729bedaa9804f6fdd1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1bd81d0ffef846729bedaa9804f6fdd1"}}, "title": "Higher vs Lower Doses of Dexamethasone in Patients with COVID\u201019 and Severe Hypoxia (COVID STEROID 2) trial: Protocol for a secondary Bayesian analysis", "authors": [{"family": "Granholm", "given": "Anders", "initials": "A", "orcid": "0000-0001-5799-7655", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d058ecb91d4c482abbee511b044ddf75.json"}}, {"family": "Munch", "given": "Marie Warrer", "initials": "MW", "orcid": "0000-0003-1127-9599", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd56f64f991042da935f6f3836e087b0.json"}}, {"family": "Myatra", "given": "Sheila Nainan", "initials": "SN"}, {"family": "Vijayaraghavan", "given": "Bharath Kumar Tirupakuzhi", "initials": "BKT"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Wahlin", "given": "Rebecka Rubenson", "initials": "RR"}, {"family": "Jakob", "given": "Stephan M", "initials": "SM"}, {"family": "Cioccari", "given": "Luca", "initials": "L"}, {"family": "Kj\u00e6r", "given": "Maj\u2010Brit N\u00f8rregaard", "initials": "MN", "orcid": "0000-0002-6536-0504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df8fa07399b448a5b689089e505dab58.json"}}, {"family": "Vesterlund", "given": "Gitte Kingo", "initials": "GK", "orcid": "0000-0001-5221-3938", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6eb5ff4bc5054887bfac267b8c8af411.json"}}, {"family": "Meyhoff", "given": "Tine Sylvest", "initials": "TS", "orcid": "0000-0002-1840-1596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/766fe5fd044944faabf6a96e8d6a72f0.json"}}, {"family": "Helleberg", "given": "Marie", "initials": "M"}, {"family": "M\u00f8ller", "given": "Morten Hylander", "initials": "MH", "orcid": "0000-0002-6378-9673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1cf88aaa5c9436a8e70ddfe39cfe4e8.json"}}, {"family": "Benfield", "given": "Thomas", "initials": "T"}, {"family": "Venkatesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Hammond", "given": "Naomi", "initials": "N"}, {"family": "Micallef", "given": "Sharon", "initials": "S"}, {"family": "Bassi", "given": "Abhinav", "initials": "A"}, {"family": "John", "given": "Oommen", "initials": "O"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Kristiansen", "given": "Klaus Tjelle", "initials": "KT"}, {"family": "Ulrik", "given": "Charlotte Suppli", "initials": "CS"}, {"family": "J\u00f8rgensen", "given": "Vibeke Lind", "initials": "VL"}, {"family": "Smitt", "given": "Margit", "initials": "M"}, {"family": "Bestle", "given": "Morten H", "initials": "MH"}, {"family": "Andreasen", "given": "Anne Sofie", "initials": "AS"}, {"family": "Poulsen", "given": "Lone Musaeus", "initials": "LM"}, {"family": "Rasmussen", "given": "Bodil Steen", "initials": "BS", "orcid": "0000-0003-2190-145X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa66146077394afea60f71d4be6daf06.json"}}, {"family": "Br\u00f8chner", "given": "Anne Craveiro", "initials": "AC"}, {"family": "Str\u00f8m", "given": "Thomas", "initials": "T"}, {"family": "M\u00f8ller", "given": "Anders", "initials": "A"}, {"family": "Khan", "given": "Mohd Saif", "initials": "MS"}, {"family": "Padmanaban", "given": "Ajay", "initials": "A"}, {"family": "Divatia", "given": "Jigeeshu Vasishtha", "initials": "JV"}, {"family": "Saseedharan", "given": "Sanjith", "initials": "S"}, {"family": "Borawake", "given": "Kapil", "initials": "K"}, {"family": "Kapadia", "given": "Farhad", "initials": "F"}, {"family": "Dixit", "given": "Subhal", "initials": "S"}, {"family": "Chawla", "given": "Rajesh", "initials": "R"}, {"family": "Shukla", "given": "Urvi", "initials": "U"}, {"family": "Amin", "given": "Pravin", "initials": "P"}, {"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Lange", "given": "Theis", "initials": "T"}, {"family": "Perner", "given": "Anders", "initials": "A", "orcid": "0000-0002-4668-0123", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5d5120bc69c433f9df2b929d6be905a.json"}}], "type": "journal-article", "published": "2021-05-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "0001-5172", "volume": "65", "issue": "5", "pages": "702-710", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) can lead to severe hypoxic respiratory failure and death. Corticosteroids decrease mortality in severely or critically ill patients with COVID-19. However, the optimal dose remains unresolved. The ongoing randomised COVID STEROID 2 trial investigates the effects of higher vs. lower doses of dexamethasone (12 vs. 6 mg intravenously daily for up to 10 days) in 1,000 adult patients with COVID-19 and severe hypoxia.\n\nThis protocol outlines the rationale and statistical methods for a secondary, pre-planned Bayesian analysis of the primary outcome (days alive without life support at day 28) and all secondary outcomes registered up to day 90. We will use hurdle-negative binomial models to estimate the mean number of days alive without life support in each group and present results as mean differences and incidence rate ratios with 95% credibility intervals (CrIs). Additional count outcomes will be analysed similarly and binary outcomes will be analysed using logistic regression models with results presented as probabilities, relative risks and risk differences with 95% CrIs. We will present probabilities of any benefit/harm, clinically important benefit/harm and probabilities of effects smaller than pre-defined clinically minimally important differences for all outcomes analysed. Analyses will be adjusted for stratification variables and conducted using weakly informative priors supplemented by sensitivity analyses using sceptic priors.\n\nThis secondary, pre-planned Bayesian analysis will supplement the primary, conventional analysis and may help clinicians, researchers and policymakers interpret the results of the COVID STEROID 2 trial while avoiding arbitrarily dichotomised interpretations of the results.", "doi": "10.1111/aas.13793", "pmid": "33583027", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-15T07:51:08.706Z", "modified": "2021-06-18T12:05:18.966Z"}, {"entity": "publication", "iuid": "306ed55d95ef4f86be1ea42f3ed30577", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/306ed55d95ef4f86be1ea42f3ed30577.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/306ed55d95ef4f86be1ea42f3ed30577"}}, "title": "Disparities in European healthcare system approaches to maintaining continuity of medication for non-communicable diseases during the COVID-19 outbreak.", "authors": [{"family": "Kardas", "given": "Przemyslaw", "initials": "P"}, {"family": "van Boven", "given": "Job Frank Martien", "initials": "JFM"}, {"family": "Pinnock", "given": "Hilary", "initials": "H"}, {"family": "Menditto", "given": "Enrica", "initials": "E"}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Tsiligianni", "given": "Ioanna", "initials": "I"}, {"family": "\u00c1gh", "given": "Tam\u00e1s", "initials": "T"}, {"family": "ENABLE collaborators", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "4", "issue": null, "pages": "100099", "issn-l": null}, "abstract": null, "doi": "10.1016/j.lanepe.2021.100099", "pmid": "33875981", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00076-4"}, {"db": "pmc", "key": "PMC8046426"}], "notes": [], "created": "2021-04-23T04:43:57.860Z", "modified": "2021-04-23T04:43:57.883Z"}, {"entity": "publication", "iuid": "35781c4aec33447ba7f2cfc838ecbc55", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/35781c4aec33447ba7f2cfc838ecbc55.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/35781c4aec33447ba7f2cfc838ecbc55"}}, "title": "Blood group type A secretors are associated with a higher risk of COVID-19 cardiovascular disease complications.", "authors": [{"family": "Mankelow", "given": "Tosti J", "initials": "TJ", "orcid": "0000-0003-3434-1973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d109f82e8870460a82565faa2f7c47dd.json"}}, {"family": "Singleton", "given": "Belinda K", "initials": "BK"}, {"family": "Moura", "given": "Pedro L", "initials": "PL", "orcid": "0000-0002-0493-5394", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf2544f4b3984c909d18106f49b9c9df.json"}}, {"family": "Stevens-Hernandez", "given": "Christian J", "initials": "CJ"}, {"family": "Cogan", "given": "Nicola M", "initials": "NM"}, {"family": "Gyorffy", "given": "Gyongyver", "initials": "G"}, {"family": "Kupzig", "given": "Sabine", "initials": "S"}, {"family": "Nichols", "given": "Luned", "initials": "L"}, {"family": "Asby", "given": "Claire", "initials": "C"}, {"family": "Pooley", "given": "Jennifer", "initials": "J"}, {"family": "Ruffino", "given": "Gabriella", "initials": "G"}, {"family": "Hosseini", "given": "Faroakh", "initials": "F"}, {"family": "Moghaddas", "given": "Fiona", "initials": "F"}, {"family": "Attwood", "given": "Marie", "initials": "M"}, {"family": "Noel", "given": "Alan", "initials": "A"}, {"family": "Cooper", "given": "Alex", "initials": "A"}, {"family": "Arnold", "given": "David T", "initials": "DT", "orcid": "0000-0003-3158-7740", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42abc73999ea4e25bed71b6538e00728.json"}}, {"family": "Hamilton", "given": "Fergus", "initials": "F", "orcid": "0000-0002-9760-4059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e862d4d0440241ecb9f9c985d638eb3d.json"}}, {"family": "Hyams", "given": "Catherine", "initials": "C", "orcid": "0000-0003-3923-1773", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e534f6c4f8c24e35b4e2df47282adfec.json"}}, {"family": "Finn", "given": "Adam", "initials": "A", "orcid": "0000-0003-1756-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd0dbeb41b344aee99a7ace518c0938c.json"}}, {"family": "Toye", "given": "Ashley M", "initials": "AM", "orcid": "0000-0003-4395-9396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/308984a5ffb44136892e9bc9d163e85d.json"}}, {"family": "Anstee", "given": "David J", "initials": "DJ", "orcid": "0000-0002-9066-1202", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2de3c70547b8454eb221ce5324686e0b.json"}}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "EJHaem", "issn": "2688-6146", "issn-l": null, "volume": "2", "issue": "2", "pages": "175-187"}, "abstract": "The SARS-CoV-2 virus causes COVID-19, an infection capable of causing severe disease and death but which can also be asymptomatic or oligosymptomatic. We investigated whether ABO blood group or secretor status was associated with COVID-19 severity. We investigated secretor status because expression of ABO glycans on secreted proteins and non-erythroid cells are controlled by a fucosyltransferase (FUT2), and inactivating FUT2 mutations result in a non-secretor phenotype which protects against some viral infections. Data combined from healthcare records and our own laboratory tests (n = 275) of hospitalized SARS-CoV-2 polymerase chain reaction positive patients confirmed higher than expected numbers of blood group A individuals compared to O (RR = 1.24, CI 95% [1.05, 1.47], p = 0.0111). There was also a significant association between group A and COVID-19-related cardiovascular complications (RR = 2.56, CI 95% [1.43, 4.55], p = 0.0011) which is independent of gender. Molecular analysis revealed that group A non-secretors are significantly less likely to be hospitalized than secretors. Testing of convalescent plasma donors, among whom the majority displayed COVID-19 symptoms and only a small minority required hospitalization, group A non-secretors were slightly over-represented. Our findings showed that group A non-secretors are not resistant to infection by SARS-CoV-2, but are more likely to experience a less severe form of associated disease.", "doi": "10.1002/jha2.180", "pmid": "34124710", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8176350"}, {"db": "pii", "key": "JHA2180"}], "notes": [], "created": "2021-06-17T07:42:38.844Z", "modified": "2023-06-19T07:44:36.576Z"}, {"entity": "publication", "iuid": "36cc2c82b9074d7480f9e6877b58a2e4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/36cc2c82b9074d7480f9e6877b58a2e4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/36cc2c82b9074d7480f9e6877b58a2e4"}}, "title": "A Method for Computerized Olfactory Assessment and Training Outside of Laboratory or Clinical Settings", "authors": [{"family": "Niedenthal", "given": "Simon", "initials": "S", "orcid": "0000-0003-4132-2287", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/afbb30dd20d446568597c1699a99e339.json"}}, {"family": "Nilsson", "given": "Johannes", "initials": "J"}, {"family": "Jerns\u00e4ther", "given": "Teodor", "initials": "T"}, {"family": "Cuartielles", "given": "David", "initials": "D"}, {"family": "Larsson", "given": "Maria", "initials": "M"}, {"family": "Olofsson", "given": "Jonas K", "initials": "JK", "orcid": "0000-0002-0856-0569", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5283494522f43cf8297e0226d08a665.json"}}], "type": "journal-article", "published": "2021-05-00", "journal": {"title": "i-Perception", "issn": "2041-6695", "volume": "12", "issue": "3", "pages": "204166952110239", "issn-l": null}, "abstract": null, "doi": "10.1177/20416695211023953", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:06:50.138Z", "modified": "2021-06-28T18:06:50.215Z"}, {"entity": "publication", "iuid": "a483737ffad34cd3a1ffd91e91ce8902", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a483737ffad34cd3a1ffd91e91ce8902.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a483737ffad34cd3a1ffd91e91ce8902"}}, "title": "The forgotten sub-regional COVID-19 response layer. The case of the WHO Eastern Mediterranean Region.", "authors": [{"family": "Ali Maher", "given": "Osama", "initials": "O"}, {"family": "Elamein Boshara", "given": "Mohamed Abdalla", "initials": "MA"}, {"family": "Pichierri", "given": "Giuseppe", "initials": "G"}, {"family": "Cegolon", "given": "Luca", "initials": "L"}, {"family": "Panu Napodano", "given": "Catello Mario", "initials": "CM"}, {"family": "Murgia", "given": "Paola", "initials": "P"}, {"family": "Bellizzi", "given": "Saverio", "initials": "S"}], "type": "journal article", "published": "2021-04-30", "journal": {"title": "J Infect Dev Ctries", "issn": "1972-2680", "volume": "15", "issue": "4", "pages": "478-479", "issn-l": null}, "abstract": "The response to the COVID-19 pandemic have been driven by epidemiology, health system characteristics and control measures in form of social/physical distancing. Guidance, information and best practices have been characterized by territorial thinking with concentration on national health system and social contexts. Information was to a large extent provided from global entities such as the World Health Organization (WHO), Centers for Disease Control and Prevention (CDC) and others. This bipolar response mechanism came to the detriment of regional and sub-regional levels. The development of the global pandemic was evaluated in terms of the performance of single countries without trying to reflect on possible regional or sub-regional results of similar characteristics in health system and social contexts. To have a clearer view of the issue of sub-regional similarities, we examined the WHO, Eastern Mediterranean Region. When examining the development of confirmed cases for countries in the region, we identified four different sub-groups similar in the development of the pandemic and the social distancing measure implemented. Despite the complicated situation, these groups gave space for thinking outside the box of traditional outbreaks or pandemic response. We think that this sub-regional approach could be very effective in addressing more characteristics and not geographically based analysis. Furthermore, this can be an area of additional conceptual approaches, modelling and concrete platforms for information and lessons learned exchange.", "doi": "10.3855/jidc.14057", "pmid": "33956646", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-17T19:05:28.720Z", "modified": "2021-05-17T19:05:28.744Z"}, {"entity": "publication", "iuid": "f8e8baec2aa84a5997263cd6b8c5edf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f8e8baec2aa84a5997263cd6b8c5edf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f8e8baec2aa84a5997263cd6b8c5edf3"}}, "title": "Fear of COVID-19 and workplace phobia among Pakistani doctors: A survey study.", "authors": [{"family": "Malik", "given": "Sadia", "initials": "S"}, {"family": "Ullah", "given": "Irfan", "initials": "I"}, {"family": "Irfan", "given": "Muhammad", "initials": "M"}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Rehman", "given": "Ibad Ur", "initials": "IU"}, {"family": "Minhas", "given": "Rafia", "initials": "R"}], "type": "journal article", "published": "2021-04-30", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "833"}, "abstract": "The novel coronavirus disease-2019 (COVID-19) has seriously affected the lives of millions of people across the world. It has also heavily burdened healthcare professionals and the virus poses serious risks for their personal and professional lives. Therefore, the present study examined the associations between fear of COVID-19 and workplace phobia among doctors in Pakistan during the COVID-19 pandemic.\r\n\r\nAn online survey was conducted among 421 doctors in Pakistan between April 10 and May 25, 2020. The Workplace Phobia Scale (WPS) and the Fear of COVID-19 Scale (FCV-19S) were the main psychometric instruments used in this study.\r\n\r\nThere was a significant positive relationship between fear of COVID-19 and workplace panic anxiety and workplace avoidance behavior. Significantly higher fear of COVID-19 was found among (i) females compared to males, (ii) doctors with 5 years or less of work experience compared to those with more than 5 years, and (iii) postgraduate trainees compared with other ranks. Two groups (doctors who were above 30 years old and postgraduate trainees) were found to have higher levels of workplace phobia compared to their counterparts. Doctors with severe levels of fear of COVID-19 had significantly higher levels of workplace panic anxiety and workplace avoidance behavior.\r\n\r\nFear of COVID-19 was significantly associated with workplace phobia which may negatively affect doctors' performance. Therefore, important steps are needed to protect doctors' health by providing sufficient resources to allay their fears and anxieties which consequently help them in carrying out their frontline duties in response to the COVID-19 pandemic.", "doi": "10.1186/s12889-021-10873-y", "pmid": "33931040", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-10873-y"}], "notes": [], "created": "2021-05-04T16:03:00.628Z", "modified": "2021-07-14T08:11:34.471Z"}, {"entity": "publication", "iuid": "0145b07c31204a1dabd9c607a0b1dccb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0145b07c31204a1dabd9c607a0b1dccb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0145b07c31204a1dabd9c607a0b1dccb"}}, "title": "A SARS-CoV-2 (COVID-19) biological network to find targets for drug repurposing.", "authors": [{"family": "Habibi", "given": "Mahnaz", "initials": "M"}, {"family": "Taheri", "given": "Golnaz", "initials": "G"}, {"family": "Aghdam", "given": "Rosa", "initials": "R"}], "type": "journal article", "published": "2021-04-30", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "9378", "issn-l": "2045-2322"}, "abstract": "The Coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus needs a fast recognition of effective drugs to save lives. In the COVID-19 situation, finding targets for drug repurposing can be an effective way to present new fast treatments. We have designed a two-step solution to address this approach. In the first step, we identify essential proteins from virus targets or their associated modules in human cells as possible drug target candidates. For this purpose, we apply two different algorithms to detect some candidate sets of proteins with a minimum size that drive a significant disruption in the COVID-19 related biological networks. We evaluate the resulted candidate proteins sets with three groups of drugs namely Covid-Drug, Clinical-Drug, and All-Drug. The obtained candidate proteins sets approve 16 drugs out of 18 in the Covid-Drug, 273 drugs out of 328 in the Clinical-Drug, and a large number of drugs in the All-Drug. In the second step, we study COVID-19 associated proteins sets and recognize proteins that are essential to disease pathology. This analysis is performed using DAVID to show and compare essential proteins that are contributed between the COVID-19 comorbidities. Our results for shared proteins show significant enrichment for cardiovascular-related, hypertension, diabetes type 2, kidney-related and lung-related diseases.", "doi": "10.1038/s41598-021-88427-w", "pmid": "33931664", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-88427-w"}, {"db": "github", "key": "(https://github.com/rosaaghdam/ Drug-Target", "description": "Datasets and the codes of the algorithms are available at the github repository"}], "notes": [], "created": "2021-05-04T16:02:32.234Z", "modified": "2021-11-18T10:16:36.362Z"}, {"entity": "publication", "iuid": "6c3d627eeb444987aba0fa10a8899671", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c3d627eeb444987aba0fa10a8899671.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c3d627eeb444987aba0fa10a8899671"}}, "title": "Prostate cancer diagnosis, staging, and treatment in Sweden during the first phase of the COVID-19 pandemic.", "authors": [{"family": "Fallara", "given": "Giuseppe", "initials": "G"}, {"family": "Sandin", "given": "Fredrik", "initials": "F"}, {"family": "Styrke", "given": "Johan", "initials": "J"}, {"family": "Carlsson", "given": "Stefan", "initials": "S"}, {"family": "Lissbrant", "given": "Ingela Franck", "initials": "IF"}, {"family": "Ahlgren", "given": "Johan", "initials": "J"}, {"family": "Bratt", "given": "Ola", "initials": "O"}, {"family": "Lambe", "given": "Mats", "initials": "M"}, {"family": "Stattin", "given": "P\u00e4r", "initials": "P"}], "type": "journal article", "published": "2021-04-29", "journal": {"title": "Scand J Urol", "issn": "2168-1813", "issn-l": null, "volume": null, "issue": null, "pages": "1-8"}, "abstract": "The first case of COVID-19 in Sweden was diagnosed in late January 2020, the first recommendations against the spread of the virus were released in mid-March, and the peak of the first wave of the pandemic was reached in March-June. The aim of this cross-sectional study was to assess the short-term effects of the first wave of the COVID-19 pandemic on prostate cancer (PCa) diagnosis, staging, and treatment.\r\n\r\nData in the National Prostate Cancer Register (NPCR) of Sweden on newly diagnosed PCa cases and on the number of diagnostic and therapeutic procedures performed between 18 March 2020 and 2 June 2020 were compared with those in the corresponding time periods in 2017-2019, as reported until January 31 of the year after each study period.\r\n\r\nDuring the study period in 2020, 36% fewer PCa cases were registered in NPCR compared with the corresponding time period in previous years: 1458 cases in 2020 vs a mean of 2285 cases in 2017-2019. The decrease in new PCa registrations was more pronounced in men above age 75 years, down 51%, than in men aged 70-75, down 37%, and in men below age 70, down 28%. There was no decrease in the number of radical prostatectomies and number of radical radiotherapy courses increased by 32%.\r\n\r\nDuring the peak of the first phase of the COVID-19 pandemic, the number of men diagnosed with PCa in Sweden decreased by one third compared with previous years, whereas there was no decrease in the number of curative treatments.", "doi": "10.1080/21681805.2021.1910341", "pmid": "33913376", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-30T04:14:25.081Z", "modified": "2021-08-25T14:32:40.013Z"}, {"entity": "publication", "iuid": "a2a8bc6a039241c1a9cbd3f58591f371", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2a8bc6a039241c1a9cbd3f58591f371.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2a8bc6a039241c1a9cbd3f58591f371"}}, "title": "OxCOVID19 Database, a multimodal data repository for better understanding the global impact of COVID-19", "authors": [{"family": "Mahdi", "given": "Adam", "initials": "A"}, {"family": "B\u0142aszczyk", "given": "Piotr", "initials": "P"}, {"family": "D\u0142otko", "given": "Pawe\u0142", "initials": "P"}, {"family": "Salvi", "given": "Dario", "initials": "D"}, {"family": "Chan", "given": "Tak Shing", "initials": "TS"}, {"family": "Harvey", "given": "John", "initials": "J"}, {"family": "Gurnari", "given": "Davide", "initials": "D"}, {"family": "Wu", "given": "Yue", "initials": "Y"}, {"family": "Farhat", "given": "Ahmad", "initials": "A"}, {"family": "Hellmer", "given": "Niklas", "initials": "N"}, {"family": "Zarebski", "given": "Alexander", "initials": "A"}, {"family": "Hogan", "given": "Bernie", "initials": "B"}, {"family": "Tarassenko", "given": "Lionel", "initials": "L"}], "type": "journal-article", "published": "2021-04-29", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": null}, "abstract": null, "doi": "10.1038/s41598-021-88481-4", "pmid": "33927237", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://github.com/covid19db/data", "description": "Code for data acquisition and cleaning used in the processing of assembling the OxCOVID19 Database"}, {"db": "URL", "key": "https://doi.org/10.6084/m9.figshare.12746150", "description": "Static data (snapshot described in the manuscript) with a DOI"}, {"db": "URL", "key": "https://github.com/covid19db/data/tree/master/data-epidemiology", "description": "Latest data, epidemiology: number of confirmed cases and deaths for different countries, etc."}, {"db": "URL", "key": "https://github.com/covid19db/data/tree/master/data-government-response", "description": "Latest data, government response: data on government response to COVID-19"}, {"db": "URL", "key": "https://github.com/covid19db/data/tree/master/data-mobility", "description": "Latest data, mobility: human mobility collected by mobile phones"}], "notes": [], "created": "2021-05-04T16:11:05.623Z", "modified": "2021-06-21T14:57:10.184Z"}, {"entity": "publication", "iuid": "37a0f26523b8445a96c1a38b8538bf9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/37a0f26523b8445a96c1a38b8538bf9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/37a0f26523b8445a96c1a38b8538bf9c"}}, "title": "Irrational pharmacy practice and inadequate health care services in Bangladesh: a lesson learned from COVID-19 pandemic.", "authors": [{"family": "Jakaria", "given": "Md", "initials": "M"}, {"family": "Azam", "given": "Shofiul", "initials": "S"}, {"family": "Siddiqui", "given": "Shafayet Ahmed", "initials": "SA"}, {"family": "Hoq", "given": "Mohammad Injamul", "initials": "MI"}, {"family": "Islam", "given": "Mohammad Safiqul", "initials": "MS"}], "type": "editorial", "published": "2021-04-29", "journal": {"title": "J Basic Clin Physiol Pharmacol", "issn": "2191-0286", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1515/jbcpp-2020-0505", "pmid": "33915611", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "jbcpp-2020-0505"}], "notes": [], "created": "2021-05-04T16:29:12.566Z", "modified": "2021-05-04T16:29:28.541Z"}, {"entity": "publication", "iuid": "b3c273a0542e4e4db386a5c04855600f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b3c273a0542e4e4db386a5c04855600f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b3c273a0542e4e4db386a5c04855600f"}}, "title": "Endothelin Antagonism and Sodium Glucose Co-transporter 2 Inhibition A Potential Combination Therapeutic Strategy for COVID-19.", "authors": [{"family": "Fisk", "given": "Marie", "initials": "M"}, {"family": "Althage", "given": "Magnus", "initials": "M"}, {"family": "Moosmang", "given": "Sven", "initials": "S"}, {"family": "Greasley", "given": "Peter J", "initials": "PJ"}, {"family": "Cope", "given": "Andrew P", "initials": "AP"}, {"family": "Jayne", "given": "David Rw", "initials": "DR"}, {"family": "Galloway", "given": "James", "initials": "J"}, {"family": "Hall", "given": "Frances", "initials": "F"}, {"family": "Wilkinson", "given": "Ian B", "initials": "IB"}, {"family": "Ambery", "given": "Philip", "initials": "P"}, {"family": "Cheriyan", "given": "Joseph", "initials": "J"}], "type": "journal article", "published": "2021-04-29", "journal": {"title": "Pulm Pharmacol Ther", "issn": "1522-9629", "volume": null, "issue": null, "pages": "102035", "issn-l": null}, "abstract": "The novel coronavirus 2019 (COVID-19) infection caused by SARS-CoV-2 is a global pandemic that requires a multi-faceted approach to tackle this unprecedent health crisis. Therapeutics to treat COVID-19 are an integral part of any such management strategy and there is a substantial unmet need for treatments for individuals most at risk of severe disease. This perspective review provides rationale of a combined therapeutic regimen of selective endothelin-A (ET-A) receptor antagonism and sodium glucose co-transporter-2 (SGLT-2) inhibition to treat COVID-19. Endothelin is a potent vasoconstrictor with pro-inflammatory and atherosclerotic effects. It is upregulated in a number of conditions including acute respiratory distress syndrome and cardiovascular disease. Endothelin mediates vasocontractility via endothelin (ET-A and ET-B) receptors on vascular smooth muscle cells (VSMCs). ET-B receptors regulate endothelin clearance and are present on endothelial cells, where in contrast to their role on VSMCs, mediate vasodilation. Therefore, selective endothelin-A (ET-A) receptor inhibition is likely the optimal approach to attenuate the injurious effects of endothelin and may reduce ventilation-perfusion mismatch and pulmonary inflammation, whilst improving pulmonary haemodynamics and oxygenation. SGLT-2 inhibition may dampen inflammatory cytokines, reduce hyperglycaemia if present, improve endothelial function, cardiovascular haemodynamics and cellular bioenergetics. This combination therapeutic approach may therefore have beneficial effects to mitigate both the pulmonary, metabolic and cardiorenal manifestations of COVID-19. Given these drug classes include medicines licensed to treat heart failure, diabetes and pulmonary hypertension respectively, information regarding their safety profile is established. Randomised controlled clinical trials are the best way to determine efficacy and safety of these medicines in COVID-19.", "doi": "10.1016/j.pupt.2021.102035", "pmid": "33933611", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1094-5539(21)00047-X"}], "notes": [], "created": "2021-05-04T16:01:42.634Z", "modified": "2021-05-04T16:02:01.268Z"}, {"entity": "publication", "iuid": "61a3cad77c90462490c5d783f81558d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61a3cad77c90462490c5d783f81558d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61a3cad77c90462490c5d783f81558d9"}}, "title": "Association of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes", "authors": [{"family": "Norman", "given": "Mikael", "initials": "M"}, {"family": "Nav\u00e9r", "given": "Lars", "initials": "L"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Ahlberg", "given": "Mia", "initials": "M"}, {"family": "Hervius Askling", "given": "Helena", "initials": "H"}, {"family": "Aronsson", "given": "Bernice", "initials": "B"}, {"family": "Bystr\u00f6m", "given": "Emma", "initials": "E"}, {"family": "Jonsson", "given": "Jerker", "initials": "J"}, {"family": "Sengpiel", "given": "Verena", "initials": "V"}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}, {"family": "H\u00e5kansson", "given": "Stellan", "initials": "S"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}], "type": "journal-article", "published": "2021-04-29", "journal": {"title": "JAMA", "issn": "0098-7484", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The outcomes of newborn infants of women testing positive for SARS-CoV-2 in pregnancy is unclear.\n\nTo evaluate neonatal outcomes in relation to maternal SARS-CoV-2 test positivity in pregnancy.\n\nNationwide, prospective cohort study based on linkage of the Swedish Pregnancy Register, the Neonatal Quality Register, and the Register for Communicable Diseases. Ninety-two percent of all live births in Sweden between March 11, 2020, and January 31, 2021, were investigated for neonatal outcomes by March 8, 2021. Infants with malformations were excluded. Infants of women who tested positive for SARS-CoV-2 were matched, directly and using propensity scores, on maternal characteristics with up to 4 comparator infants.\n\nMaternal test positivity for SARS-CoV-2 in pregnancy.\n\nIn-hospital mortality; neonatal resuscitation; admission for neonatal care; respiratory, circulatory, neurologic, infectious, gastrointestinal, metabolic, and hematologic disorders and their treatments; length of hospital stay; breastfeeding; and infant test positivity for SARS-CoV-2.\n\nOf 88 159 infants (49.0% girls), 2323 (1.6%) were delivered by mothers who tested positive for SARS-CoV-2. The mean gestational age of infants of SARS-CoV-2-positive mothers was 39.2 (SD, 2.2) weeks vs 39.6 (SD, 1.8) weeks for comparator infants, and the proportions of preterm infants (gestational age <37 weeks) were 205/2323 (8.8%) among infants of SARS-CoV-2-positive mothers and 4719/85 836 (5.5%) among comparator infants. After matching on maternal characteristics, maternal SARS-CoV-2 test positivity was significantly associated with admission for neonatal care (11.7% vs 8.4%; odds ratio [OR], 1.47; 95% CI, 1.26-1.70) and with neonatal morbidities such as respiratory distress syndrome (1.2% vs 0.5%; OR, 2.40; 95% CI, 1.50-3.84), any neonatal respiratory disorder (2.8% vs 2.0%; OR, 1.42; 95% CI, 1.07-1.90), and hyperbilirubinemia (3.6% vs 2.5%; OR, 1.47; 95% CI, 1.13-1.90). Mortality (0.30% vs 0.12%; OR, 2.55; 95% CI, 0.99-6.57), breastfeeding rates at discharge (94.4% vs 95.1%; OR, 0.84; 95% CI, 0.67-1.05), and length of stay in neonatal care (median, 6 days in both groups; difference, 0 days; 95% CI, -2 to 7 days) did not differ significantly between the groups. Twenty-one infants (0.90%) of SARS-CoV-2-positive mothers tested positive for SARS-CoV-2 in the neonatal period; 12 did not have neonatal morbidity, 9 had diagnoses with unclear relation to SARS-CoV-2, and none had congenital pneumonia.\n\nIn a nationwide cohort of infants in Sweden, maternal SARS-CoV-2 infection in pregnancy was significantly associated with small increases in some neonatal morbidities. Given the small numbers of events for many of the outcomes and the large number of statistical comparisons, the findings should be interpreted as exploratory.", "doi": "10.1001/jama.2021.5775", "pmid": "33914014", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-29T16:47:53.604Z", "modified": "2021-04-30T04:16:25.471Z"}, {"entity": "publication", "iuid": "f5e42570b7434d6ab37a5f6d964a3fdf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f5e42570b7434d6ab37a5f6d964a3fdf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f5e42570b7434d6ab37a5f6d964a3fdf"}}, "title": "The association between high risk of sleep apnea, comorbidities, and risk of COVID-19: a population-based international harmonized study", "authors": [{"family": "Chung", "given": "Frances", "initials": "F"}, {"family": "Waseem", "given": "Rida", "initials": "R"}, {"family": "Pham", "given": "Chi", "initials": "C"}, {"family": "Penzel", "given": "Thomas", "initials": "T"}, {"family": "Han", "given": "Fang", "initials": "F"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Espie", "given": "Colin A", "initials": "CA"}, {"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J"}, {"family": "Saaresranta", "given": "Tarja", "initials": "T"}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK"}, {"family": "Nadorff", "given": "Michael R", "initials": "MR"}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L"}, {"family": "Plazzi", "given": "Guiseppe", "initials": "G"}, {"family": "Merikanto", "given": "Ilona", "initials": "I"}, {"family": "Matsui", "given": "Kentaro", "initials": "K"}, {"family": "Leger", "given": "Damien", "initials": "D"}, {"family": "Sieminski", "given": "Mariusz", "initials": "M"}, {"family": "Mota-Rolim", "given": "Sergio", "initials": "S"}, {"family": "Inoue", "given": "Yuichi", "initials": "Y"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "International COVID Sleep Study (ICOSS) group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-04-28", "journal": {"title": "Sleep Breath", "issn": "1522-1709", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Obstructive sleep apnea (OSA) may increase the risk of severe COVID-19; however, the level of potential modulation has not yet been established. The objective of the study was to determine the association between high risk of OSA, comorbidities, and increased risk for COVID-19, hospitalization, and intensive care unit (ICU) treatment.\r\n\r\nWe conducted a cross-sectional population-based web survey in adults in 14 countries/regions. The survey included sociodemographic variables and comorbidities. Participants were asked questions about COVID-19, hospitalization, and ICU treatment. Standardized questionnaire (STOP questionnaire for high risk of OSA) was included. Multivariable logistic regression was conducted adjusting for various factors.\r\n\r\nOut of 26,539 respondents, 20,598 (35.4% male) completed the survey. Mean age and BMI of participants were 41.5 \u00b1 16.0 years and 24.0 \u00b1 5.0 kg/m 2, respectively. The prevalence of physician-diagnosed OSA was 4.1% and high risk of OSA was 9.5%. We found that high risk of OSA (adjusted odds ratio (aOR) 1.72, 95% confidence interval (CI): 1.20, 2.47) and diabetes (aOR 2.07, 95% CI: 1.23, 3.48) were associated with reporting of a COVID-19 diagnosis. High risk for OSA (aOR 2.11, 95% CI: 1.10-4.01), being male (aOR: 2.82, 95% CI: 1.55-5.12), having diabetes (aOR: 3.93, 95% CI: 1.70-9.12), and having depression (aOR: 2.33, 95% CI: 1.15-4.77) were associated with increased risk of hospitalization or ICU treatment.\r\n\r\nParticipants at high risk of OSA had increased odds of having COVID-19 and were two times more likely to be hospitalized or treated in ICU.", "doi": "10.1007/s11325-021-02373-5", "pmid": "33907966", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11325-021-02373-5"}], "notes": [], "created": "2021-04-29T09:42:48.077Z", "modified": "2021-07-14T08:09:42.536Z"}, {"entity": "publication", "iuid": "4bfc7bf6f16c4fa9b82e7973184438e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4bfc7bf6f16c4fa9b82e7973184438e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4bfc7bf6f16c4fa9b82e7973184438e2"}}, "title": "SVEPM 2020 - Resilience and community support in the first year of the COVID-19 pandemic: The Society for Veterinary Epidemiology and Preventive Medicine Annual Conference, extraordinarily held online.", "authors": [{"family": "D\u00f3rea", "given": "Fernanda C", "initials": "FC"}, {"family": "Vergne", "given": "Timoth\u00e9e", "initials": "T"}, {"family": "Brennan", "given": "Marnie", "initials": "M"}, {"family": "van Schaik", "given": "Gerdien", "initials": "G"}, {"family": "Barrett", "given": "Damien", "initials": "D"}, {"family": "Carmo", "given": "Lu\u00eds Pedro", "initials": "LP"}, {"family": "Robinson", "given": "Philip A", "initials": "PA"}, {"family": "Brodbelt", "given": "Dave C", "initials": "DC"}, {"family": "McIntyre", "given": "K Marie", "initials": "KM"}], "type": "editorial", "published": "2021-04-28", "journal": {"title": "Prev Vet Med", "issn": "1873-1716", "volume": "191", "issue": null, "pages": "105368", "issn-l": null}, "abstract": null, "doi": "10.1016/j.prevetmed.2021.105368", "pmid": "33933917", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0167-5877(21)00112-4"}], "notes": [], "created": "2021-05-04T16:01:16.608Z", "modified": "2021-05-04T16:01:16.631Z"}, {"entity": "publication", "iuid": "26e5d7282b7a402c9c5a0c78f0b36244", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26e5d7282b7a402c9c5a0c78f0b36244.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26e5d7282b7a402c9c5a0c78f0b36244"}}, "title": "Occupational burnout and job satisfaction among physicians in times of COVID-19 crisis: a convergent parallel mixed-method study.", "authors": [{"family": "Alrawashdeh", "given": "Hamzeh Mohammad", "initials": "HM"}, {"family": "Al-Tammemi", "given": "Ala'a B", "initials": "AB"}, {"family": "Alzawahreh", "given": "Mohammad Kh", "initials": "MK"}, {"family": "Al-Tamimi", "given": "Ashraf", "initials": "A"}, {"family": "Elkholy", "given": "Mohamed", "initials": "M"}, {"family": "Al Sarireh", "given": "Fawaz", "initials": "F"}, {"family": "Abusamak", "given": "Mohammad", "initials": "M"}, {"family": "Elehamer", "given": "Nafisa M K", "initials": "NMK"}, {"family": "Malkawi", "given": "Ahmad", "initials": "A"}, {"family": "Al-Dolat", "given": "Wedad", "initials": "W"}, {"family": "Abu-Ismail", "given": "Luai", "initials": "L"}, {"family": "Al-Far", "given": "Ali", "initials": "A"}, {"family": "Ghoul", "given": "Imene", "initials": "I"}], "type": "journal article", "published": "2021-04-28", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "811"}, "abstract": "Healthcare professionals including physicians were subjected to an increased workload during the COVID-19 crisis, leaving them exposed to significant physical and psychological distress. Therefore, our present study aimed to (i) assess the prevalence of burnout and levels of job satisfaction among physicians in Jordan, and (ii) explore physicians' opinions, experiences, and perceptions during the pandemic crisis.\r\n\r\nThis was a mixed-method study that utilized a structured web-based questionnaire and semi-structured individual interviews. The 10-Item Burnout Measure-Short version (BMS), and the 5-Item Short Index of Job Satisfaction (SIJS) were adopted to assess occupational burnout and job satisfaction, respectively. Semi-structured interviews were conducted, based on a conceptual framework that was developed from Herzberg's Two-Factor Theory of Motivation and Job Demands-Resources Model. Descriptive statistics and regression models, as well as inductive thematic analysis, were used to analyze quantitative and qualitative data, respectively.\r\n\r\nA total of 973 survey responses and 11 interviews were included in our analysis. The prevalence of burnout among physicians was (57.7%). Several significant factors were positively associated with burnout, including female gender, working at highly loaded hospitals, working for long hours, doing night shifts, lack of sufficient access to personal protective equipment, and being positively tested for SARS-CoV-2. Regarding job satisfaction, regression analysis revealed that age was positively associated with higher levels of job satisfaction. On contrary, being a general practitioner or specialist, working at highly loaded hospitals, low salaries, and suffering from burnout have predicted lower levels of job satisfaction. Besides, four themes have emerged from the thematic analysis: (i) Work-induced psychological distress during the pandemic, (ii) Decision-driven satisfactory and dissatisfactory experiences, (iii) Impact of the pandemic on doctor-patient communication and professional skills, and (iv) Economic impacts of the pandemic crisis and lockdown.\r\n\r\nA significant physical and psychological burden was associated with the COVID-19 pandemic. Reliable efforts should be implemented aiming at protecting physicians' physical and mental wellbeing, enhancing their working conditions, and raising awareness about burnout. Evidence-based decisions and proper utilization of financial and human resources at institutional and national levels are believed to be crucial for the sustainability of the health workforce, especially in crises.", "doi": "10.1186/s12889-021-10897-4", "pmid": "33906619", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-10897-4"}, {"db": "URL", "key": "https://doi.org/10.6084/m9.figshare.14058185.v1", "description": "Raw dataset: individual-level demographic, occupational, COVID-19, burnout, etc. data"}], "notes": [], "created": "2021-04-29T09:51:29.677Z", "modified": "2021-07-14T08:10:43.856Z"}, {"entity": "publication", "iuid": "0d490bda6d954f7d80ad15406ed1d900", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d490bda6d954f7d80ad15406ed1d900.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d490bda6d954f7d80ad15406ed1d900"}}, "title": "Organotypic human ex vivo models for coronavirus disease 2019 research and drug development.", "authors": [{"family": "Youhanna", "given": "Sonia", "initials": "S"}, {"family": "Wright", "given": "Shane C", "initials": "SC"}, {"family": "Lauschke", "given": "Volker M", "initials": "VM"}], "type": "journal article", "published": "2021-04-27", "journal": {"title": "Curr Opin Pharmacol", "issn": "1471-4973", "volume": "59", "issue": null, "pages": "11-18", "issn-l": null}, "abstract": "Since the discovery of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019, intense research efforts on an unprecedented scale have focused on the study of viral entry mechanisms and adaptive immunity. While the identification of angiotensin-converting enzyme 2 (ACE2) and other co-receptors has elucidated the molecular and structural basis for viral entry, the pathobiological mechanisms of SARS-CoV-2 in human tissues are less understood. Recent advances in bioengineering have opened opportunities for the use of organotypic human tissue models to investigate host-virus interactions and test antiviral drug candidates in a physiological context. Although it is too early to accurately quantify the added value of these systems compared with conventional cell systems, it can be assumed that these advanced three-dimensional (3D) models contribute toward improved result translation. This mini-review summarizes recent work to study SARS-CoV-2 infection in human 3D tissue models with an emphasis on the pharmacological tools that have been developed to understand and prevent viral entry and replication.", "doi": "10.1016/j.coph.2021.04.006", "pmid": "34029832", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1471-4892(21)00050-3"}, {"db": "pmc", "key": "PMC8075816"}], "notes": [], "created": "2021-05-29T15:42:16.272Z", "modified": "2021-05-29T15:42:16.294Z"}, {"entity": "publication", "iuid": "ecfb81283b8d4464a1a186821f9831ab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ecfb81283b8d4464a1a186821f9831ab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ecfb81283b8d4464a1a186821f9831ab"}}, "title": "Mathematical modeling suggests pre-existing immunity to SARS-CoV-2", "authors": [{"family": "Carlsson", "given": "Marcus", "initials": "M"}, {"family": "Hatem", "given": "Gad", "initials": "G"}, {"family": "Soderberg-Naucler", "given": "Cecilia", "initials": "C"}], "type": "posted-content", "published": "2021-04-27", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.21.21255782", "pmid": null, "labels": {"Type: Preprint": null, "Category: Other": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-29T16:15:48.609Z", "modified": "2021-04-30T13:02:19.665Z"}, {"entity": "publication", "iuid": "d4848d32e81845a799c9c4615ed3dc81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4848d32e81845a799c9c4615ed3dc81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4848d32e81845a799c9c4615ed3dc81"}}, "title": "A combination of N and S antigens with IgA and IgG measurement strengthens the accuracy of SARS-CoV-2 serodiagnostics", "authors": [{"family": "Jalkanen", "given": "Pinja", "initials": "P"}, {"family": "Pasternack", "given": "Arja", "initials": "A"}, {"family": "Maljanen", "given": "Sari", "initials": "S"}, {"family": "Mel\u00e9n", "given": "Krister", "initials": "K"}, {"family": "Kolehmainen", "given": "Pekka", "initials": "P"}, {"family": "Huttunen", "given": "Moona", "initials": "M"}, {"family": "Lundberg", "given": "Rickard", "initials": "R"}, {"family": "Tripathi", "given": "Lav", "initials": "L"}, {"family": "Khan", "given": "Hira", "initials": "H"}, {"family": "Ritvos", "given": "Mikael A", "initials": "MA"}, {"family": "Naves", "given": "Rauno", "initials": "R"}, {"family": "Haveri", "given": "Anu", "initials": "A"}, {"family": "\u00d6sterlund", "given": "Pamela", "initials": "P"}, {"family": "Kuivanen", "given": "Suvi", "initials": "S"}, {"family": "J\u00e4\u00e4skel\u00e4inen", "given": "Anne J", "initials": "AJ"}, {"family": "Kurkela", "given": "Satu", "initials": "S"}, {"family": "Lappalainen", "given": "Maija", "initials": "M"}, {"family": "Rantas\u00e4rkk\u00e4", "given": "Kaisa", "initials": "K"}, {"family": "Vuorinen", "given": "Tytti", "initials": "T"}, {"family": "Hyt\u00f6nen", "given": "Jukka", "initials": "J"}, {"family": "Waris", "given": "Matti", "initials": "M"}, {"family": "Tauriainen", "given": "Sisko", "initials": "S"}, {"family": "Ritvos", "given": "Olli", "initials": "O"}, {"family": "Kakkola", "given": "Laura", "initials": "L"}, {"family": "Julkunen", "given": "Ilkka", "initials": "I"}], "type": "journal-article", "published": "2021-04-27", "journal": {"title": "The Journal of Infectious Diseases", "issn": "0022-1899", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1093/infdis/jiab222", "pmid": null, "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-29T10:13:44.262Z", "modified": "2021-04-29T10:15:16.292Z"}, {"entity": "publication", "iuid": "4b46fb9b6a364fffb0cdb5048b5d59ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b46fb9b6a364fffb0cdb5048b5d59ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b46fb9b6a364fffb0cdb5048b5d59ca"}}, "title": "When face-to-face interviews are not possible: tips and tricks for video, telephone, online chat, and email interviews in qualitative research.", "authors": [{"family": "Saarij\u00e4rvi", "given": "Markus", "initials": "M"}, {"family": "Bratt", "given": "Ewa-Lena", "initials": "EL"}], "type": "journal article", "published": "2021-04-24", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "volume": null, "issue": null, "issn-l": null}, "abstract": "Face-to-face interviews have long been the norm for conducting qualitative interviews in healthcare research. However, the Covid-19 pandemic has accelerated the need to explore alternative methods. This, along with the swift digitalization of healthcare, has led to video, telephone, and online interactions becoming increasingly used. The use of new techniques to carry out interviews through video, telephone, and online applications all come with benefits and drawbacks. In this article, three ways of collecting data through qualitative interviews are described and their uses exemplified through a project investigating the impact of a transition program for adolescents with congenital heart disease.", "doi": "10.1093/eurjcn/zvab038", "pmid": "33893797", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "6249551"}], "notes": [], "created": "2021-04-29T15:29:20.298Z", "modified": "2021-04-29T15:29:20.308Z"}, {"entity": "publication", "iuid": "2829e953fc844de68b4eabeba69828f6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2829e953fc844de68b4eabeba69828f6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2829e953fc844de68b4eabeba69828f6"}}, "title": "SARS-CoV-2 rapid antigen test: High sensitivity to detect infectious virus.", "authors": [{"family": "Nordgren", "given": "Johan", "initials": "J"}, {"family": "Sharma", "given": "Sumit", "initials": "S"}, {"family": "Olsson", "given": "Henrik", "initials": "H"}, {"family": "J\u00e4mtberg", "given": "Mikael", "initials": "M"}, {"family": "Falkeborn", "given": "Tina", "initials": "T"}, {"family": "Svensson", "given": "Lennart", "initials": "L"}, {"family": "Hagbom", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2021-04-24", "journal": {"title": "J Clin Virol", "issn": "1873-5967", "volume": "140", "issue": null, "pages": "104846", "issn-l": null}, "abstract": "The COVID-19 pandemic has highlighted the need for rapid, cost effective and easy-to-use diagnostic tools for SARS-CoV-2 infections that can be used in point of care settings to limit disease transmission.\n\nWe evaluated two rapid antigen immunochromatographic tests, Abbott Panbio\u2122 COVID-19 Ag Rapid Test (Panbio) and Zhejiang Orient Gene/Healgen Biotech Coronavirus Ag rapid test cassette (Orient gene) for detection of infectious SARS-CoV-2.\n\nThe tests were evaluated on nasopharyngeal samples taken from individuals having respiratory and/or COVID-19 related symptoms, which had been analyzed for SARS-CoV-2 RNA using real-time PCR. In total 156 PCR-positive, and 130 (Panbio) and 176 (Orient Gene) PCR-negative samples were analyzed. Overall sensitivity and specificity were 71.8% and 100% for Panbio and 79.5% and 74.4% for the Orient Gene test respectively. The false positives by the Orient Gene test were verified as SARS-CoV-2 negative by in-house real-time PCR assay and were negative for the four seasonal coronaviruses. Subgroup analysis revealed that the antigen tests had high sensitivity for samples with Ct-values <25 (>88%) and for samples containing infectious viruses as determined by cultivation on Vero cells, 94.1% and 97.1% for the Panbio and Orient gene tests, respectively. Furthermore, both tests had a sensitivity of <50 picogram for nucleocapsid protein. No sample with a Ct-value >27 was shown to contain infectious virus.\n\nThe results indicate that the rapid antigen tests, especially the Panbio tests may be a valuable tool to detect contagious persons during the ongoing pandemic.", "doi": "10.1016/j.jcv.2021.104846", "pmid": "33971580", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Serology": null}, "xrefs": [{"db": "pii", "key": "S1386-6532(21)00113-X"}, {"db": "pmc", "key": "PMC8105081"}], "notes": [], "created": "2021-05-17T18:59:51.442Z", "modified": "2021-05-17T19:00:05.499Z"}, {"entity": "publication", "iuid": "049415536c104aac889ad2589eb7e290", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/049415536c104aac889ad2589eb7e290.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/049415536c104aac889ad2589eb7e290"}}, "title": "Post-COVID syndrome: Need to include risk of addiction in research and multi-disciplinary clinical work.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "letter", "published": "2021-04-24", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "issn-l": null, "volume": "301", "issue": null, "pages": "113961"}, "abstract": null, "doi": "10.1016/j.psychres.2021.113961", "pmid": "33957379", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(21)00258-4"}, {"db": "pmc", "key": "PMC8064891"}], "notes": [], "created": "2021-05-17T19:06:00.630Z", "modified": "2021-07-02T14:28:42.169Z"}, {"entity": "publication", "iuid": "a8d2f9e9aefb4fca8d9c02c651aecb50", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8d2f9e9aefb4fca8d9c02c651aecb50.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8d2f9e9aefb4fca8d9c02c651aecb50"}}, "title": "Cyanobacteria-From the Oceans to the Potential Biotechnological and Biomedical Applications.", "authors": [{"family": "Khalifa", "given": "Shaden A M", "initials": "SAM"}, {"family": "Shedid", "given": "Eslam S", "initials": "ES"}, {"family": "Saied", "given": "Essa M", "initials": "EM"}, {"family": "Jassbi", "given": "Amir Reza", "initials": "AR"}, {"family": "Jamebozorgi", "given": "Fatemeh H", "initials": "FH"}, {"family": "Rateb", "given": "Mostafa E", "initials": "ME"}, {"family": "Du", "given": "Ming", "initials": "M"}, {"family": "Abdel-Daim", "given": "Mohamed M", "initials": "MM"}, {"family": "Kai", "given": "Guo-Yin", "initials": "GY"}, {"family": "Al-Hammady", "given": "Montaser A M", "initials": "MAM"}, {"family": "Xiao", "given": "Jianbo", "initials": "J"}, {"family": "Guo", "given": "Zhiming", "initials": "Z"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}], "type": "journal article", "published": "2021-04-24", "journal": {"title": "Mar Drugs", "issn": "1660-3397", "volume": "19", "issue": "5", "issn-l": null}, "abstract": "Cyanobacteria are photosynthetic prokaryotic organisms which represent a significant source of novel, bioactive, secondary metabolites, and they are also considered an abundant source of bioactive compounds/drugs, such as dolastatin, cryptophycin 1, curacin toyocamycin, phytoalexin, cyanovirin-N and phycocyanin. Some of these compounds have displayed promising results in successful Phase I, II, III and IV clinical trials. Additionally, the cyanobacterial compounds applied to medical research have demonstrated an exciting future with great potential to be developed into new medicines. Most of these compounds have exhibited strong pharmacological activities, including neurotoxicity, cytotoxicity and antiviral activity against HCMV, HSV-1, HHV-6 and HIV-1, so these metabolites could be promising candidates for COVID-19 treatment. Therefore, the effective large-scale production of natural marine products through synthesis is important for resolving the existing issues associated with chemical isolation, including small yields, and may be necessary to better investigate their biological activities. Herein, we highlight the total synthesized and stereochemical determinations of the cyanobacterial bioactive compounds. Furthermore, this review primarily focuses on the biotechnological applications of cyanobacteria, including applications as cosmetics, food supplements, and the nanobiotechnological applications of cyanobacterial bioactive compounds in potential medicinal applications for various human diseases are discussed.", "doi": "10.3390/md19050241", "pmid": "33923369", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "md19050241"}], "notes": [], "created": "2021-05-04T16:23:54.908Z", "modified": "2021-05-04T16:23:54.929Z"}, {"entity": "publication", "iuid": "3cffa71e6f75463d8f3f0744bccf3afb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3cffa71e6f75463d8f3f0744bccf3afb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3cffa71e6f75463d8f3f0744bccf3afb"}}, "title": "Call for a pan-European COVID-19 response must be comprehensive - Authors' reply.", "authors": [{"family": "Priesemann", "given": "Viola", "initials": "V"}, {"family": "Brinkmann", "given": "Melanie M", "initials": "MM"}, {"family": "Ciesek", "given": "Sandra", "initials": "S"}, {"family": "Cuschieri", "given": "Sarah", "initials": "S"}, {"family": "Czypionka", "given": "Thomas", "initials": "T"}, {"family": "Giordano", "given": "Giulia", "initials": "G"}, {"family": "Hanson", "given": "Claudia", "initials": "C"}, {"family": "Hens", "given": "Niel", "initials": "N"}, {"family": "Iftekhar", "given": "Emil", "initials": "E"}, {"family": "Klimek", "given": "Peter", "initials": "P"}, {"family": "Kretzschmar", "given": "Mirjam", "initials": "M"}, {"family": "Peichl", "given": "Andreas", "initials": "A"}, {"family": "Perc", "given": "Matja\u017e", "initials": "M"}, {"family": "Sannino", "given": "Francesco", "initials": "F"}, {"family": "Schernhammer", "given": "Eva", "initials": "E"}, {"family": "Schmidt", "given": "Alexander", "initials": "A"}, {"family": "Staines", "given": "Anthony", "initials": "A"}, {"family": "Szczurek", "given": "Ewa", "initials": "E"}], "type": "letter", "published": "2021-04-24", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "397", "issue": "10284", "pages": "1541", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(21)00462-1", "pmid": "33894827", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)00462-1"}], "notes": [], "created": "2021-04-29T15:28:23.486Z", "modified": "2021-04-29T15:28:42.254Z"}, {"entity": "publication", "iuid": "985d6927c03444debef535dd9f32fad3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/985d6927c03444debef535dd9f32fad3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/985d6927c03444debef535dd9f32fad3"}}, "title": "Epidemiological analysis of 3,219 COVID-19 outbreaks in the state of Baden-Wuerttemberg, Germany.", "authors": [{"family": "Dressler", "given": "Aparna", "initials": "A"}, {"family": "Finci", "given": "Iris", "initials": "I"}, {"family": "Wagner-Wiening", "given": "Christiane", "initials": "C"}, {"family": "Eichner", "given": "Martin", "initials": "M"}, {"family": "Brockmann", "given": "Stefan O", "initials": "SO"}], "type": "journal article", "published": "2021-04-23", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "issn-l": null, "volume": null, "issue": null, "pages": "1-18"}, "abstract": null, "doi": "10.1017/S0950268821000911", "pmid": "33888172", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0950268821000911"}], "notes": [], "created": "2021-04-29T16:11:39.530Z", "modified": "2021-04-29T16:32:25.071Z"}, {"entity": "publication", "iuid": "0bc38cc4b8e84a82a44e04503c54065a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0bc38cc4b8e84a82a44e04503c54065a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0bc38cc4b8e84a82a44e04503c54065a"}}, "title": "COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system.", "authors": [{"family": "Rysz", "given": "Susanne", "initials": "S"}, {"family": "Al-Saadi", "given": "Jonathan", "initials": "J"}, {"family": "Sj\u00f6str\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Farm", "given": "Maria", "initials": "M"}, {"family": "Campoccia Jalde", "given": "Francesca", "initials": "F"}, {"family": "Platt\u00e9n", "given": "Michael6", "initials": "M"}, {"family": "Eriksson", "given": "Helen", "initials": "H"}, {"family": "Klein", "given": "Margareta", "initials": "M"}, {"family": "Vargas-Paris", "given": "Roberto", "initials": "R"}, {"family": "Nyr\u00e9n", "given": "Sven", "initials": "S"}, {"family": "Abdula", "given": "Goran", "initials": "G"}, {"family": "Ouellette", "given": "Russell", "initials": "R"}, {"family": "Granberg", "given": "Tobias", "initials": "T"}, {"family": "Jonsson Fagerlund", "given": "Malin", "initials": "M"}, {"family": "Lundberg", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2021-04-23", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "2417"}, "abstract": "SARS-CoV-2 uses ACE2, an inhibitor of the Renin-Angiotensin-Aldosterone System (RAAS), for cellular entry. Studies indicate that RAAS imbalance worsens the prognosis in COVID-19. We present a consecutive retrospective COVID-19 cohort with findings of frequent pulmonary thromboembolism (17%), high pulmonary artery pressure (60%) and lung MRI perfusion disturbances. We demonstrate, in swine, that infusing angiotensin II or blocking ACE2 induces increased pulmonary artery pressure, reduces blood oxygenation, increases coagulation, disturbs lung perfusion, induces diffuse alveolar damage, and acute tubular necrosis compared to control animals. We further demonstrate that this imbalanced state can be ameliorated by infusion of an angiotensin receptor blocker and low-molecular-weight heparin. In this work, we show that a pathophysiological state in swine induced by RAAS imbalance shares several features with the clinical COVID-19 presentation. Therefore, we propose that severe COVID-19 could partially be driven by a RAAS imbalance.", "doi": "10.1038/s41467-021-22713-z", "pmid": "33893295", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-22713-z"}], "notes": [], "created": "2021-04-26T17:40:04.765Z", "modified": "2021-04-29T15:33:57.903Z"}, {"entity": "publication", "iuid": "0efcd0187d4f4c129e1c179bfb5452d8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0efcd0187d4f4c129e1c179bfb5452d8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0efcd0187d4f4c129e1c179bfb5452d8"}}, "title": "Meal and Sleep Timing before and during the COVID-19 Pandemic: A Cross-Sectional Anonymous Survey Study from Sweden.", "authors": [{"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Brand\u00e3o", "given": "Luiz Eduardo Mateus", "initials": "LEM"}, {"family": "Merikanto", "given": "Ilona", "initials": "I"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J"}], "type": "journal article", "published": "2021-04-22", "journal": {"title": "Clocks Sleep", "issn": "2624-5175", "volume": "3", "issue": "2", "pages": "251-258", "issn-l": null}, "abstract": "The COVID-19 pandemic and related restrictions, such as stay-at-home-orders, have significantly altered daily routines and lifestyles. Given their importance for metabolic health, we herein compared sleep and meal timing parameters during vs. before the COVID-19 pandemic based on subjective recall, in an anonymous Swedish survey. Among 191 adults (mean age: 47 years; 77.5% females), we show that social jetlag, i.e., the mismatch in sleep midpoint between work and free days, was reduced by about 17 min during the pandemic compared with the pre-pandemic state ( p < 0.001). Concomitantly, respondents' sleep midpoint was shifted toward morning hours during workdays (p < 0.001). A later daily eating midpoint accompanied the shift in sleep timing (p = 0.001). This effect was mainly driven by a later scheduled first meal (p < 0.001). No difference in the timing of the day's last meal was found (p = 0.814). Although our survey was limited in terms of sample size and by being cross-sectional, our results suggest that the delay in sleep timing due to the COVID-19 pandemic was accompanied by a corresponding shift in the timing of early but not late meals.", "doi": "10.3390/clockssleep3020015", "pmid": "33921946", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "clockssleep3020015"}], "notes": [], "created": "2021-05-04T16:24:15.921Z", "modified": "2021-05-04T16:24:15.944Z"}, {"entity": "publication", "iuid": "6e1f6b9ec31a455083dcfdd8f136d90d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e1f6b9ec31a455083dcfdd8f136d90d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e1f6b9ec31a455083dcfdd8f136d90d"}}, "title": "Making Waves: Collaboration in the time of SARS-CoV-2 - rapid development of an international co-operation and wastewater surveillance database to support public health decision-making.", "authors": [{"family": "Lundy", "given": "Lian", "initials": "L"}, {"family": "Fatta-Kassinos", "given": "Despo", "initials": "D"}, {"family": "Slobodnik", "given": "Jaroslav", "initials": "J"}, {"family": "Karaolia", "given": "Popi", "initials": "P"}, {"family": "Cirka", "given": "Lubos", "initials": "L"}, {"family": "Kreuzinger", "given": "Norbert", "initials": "N"}, {"family": "Castiglioni", "given": "Sara", "initials": "S"}, {"family": "Bijlsma", "given": "Lubertus", "initials": "L"}, {"family": "Dulio", "given": "Valeria", "initials": "V"}, {"family": "Deviller", "given": "Genevi\u00e8ve", "initials": "G"}, {"family": "Lai", "given": "Foon Yin", "initials": "FY"}, {"family": "Alygizakis", "given": "Nikiforos", "initials": "N"}, {"family": "Barneo", "given": "Manuela", "initials": "M"}, {"family": "Baz-Lomba", "given": "Jose Antonio", "initials": "JA"}, {"family": "B\u00e9en", "given": "Frederic", "initials": "F"}, {"family": "C\u00edchov\u00e1", "given": "Marianna", "initials": "M"}, {"family": "Conde-P\u00e9rez", "given": "Kelly", "initials": "K"}, {"family": "Covaci", "given": "Adrian", "initials": "A"}, {"family": "Donner", "given": "Erica", "initials": "E"}, {"family": "Ficek", "given": "Andrej", "initials": "A"}, {"family": "Hassard", "given": "Francis", "initials": "F"}, {"family": "Hedstr\u00f6m", "given": "Annelie", "initials": "A"}, {"family": "Hernandez", "given": "F\u00e9lix", "initials": "F"}, {"family": "Jansk\u00e1", "given": "Veronika", "initials": "V"}, {"family": "Jellison", "given": "Kristen", "initials": "K"}, {"family": "Hofman", "given": "Jan", "initials": "J"}, {"family": "Hill", "given": "Kelly", "initials": "K"}, {"family": "Hong", "given": "Pei-Ying", "initials": "P"}, {"family": "Kasprzyk-Hordern", "given": "Barbara", "initials": "B"}, {"family": "Kolarevi\u0107", "given": "Stoimir", "initials": "S"}, {"family": "Krahulec", "given": "Jan", "initials": "J"}, {"family": "Lambropoulou", "given": "Dimitra", "initials": "D"}, {"family": "de Llanos", "given": "Rosa", "initials": "R"}, {"family": "Macku\u013eak", "given": "Tom\u00e1\u0161", "initials": "T"}, {"family": "Martinez-Garc\u00eda", "given": "Lorena", "initials": "L"}, {"family": "Mart\u00ednez", "given": "Francisco", "initials": "F"}, {"family": "Medema", "given": "Gertjan", "initials": "G"}, {"family": "Micsinai", "given": "Adrienn", "initials": "A"}, {"family": "Myrmel", "given": "Mette", "initials": "M"}, {"family": "Nasser", "given": "Mohammed", "initials": "M"}, {"family": "Niederst\u00e4tter", "given": "Harald", "initials": "H"}, {"family": "Nozal", "given": "Leonor", "initials": "L"}, {"family": "Oberacher", "given": "Herbert", "initials": "H"}, {"family": "O\u010den\u00e1\u0161kov\u00e1", "given": "V\u011bra", "initials": "V"}, {"family": "Ogorzaly", "given": "Leslie", "initials": "L"}, {"family": "Papadopoulos", "given": "Dimitrios", "initials": "D"}, {"family": "Peinado", "given": "Beatriz", "initials": "B"}, {"family": "Pitk\u00e4nen", "given": "Tarja", "initials": "T"}, {"family": "Poza", "given": "Margarita", "initials": "M"}, {"family": "Rumbo-Feal", "given": "Soraya", "initials": "S"}, {"family": "S\u00e1nchez", "given": "Maria Blanca", "initials": "MB"}, {"family": "Sz\u00e9kely", "given": "Anna J", "initials": "AJ"}, {"family": "Soltysova", "given": "Andrea", "initials": "A"}, {"family": "Thomaidis", "given": "Nikolaos S", "initials": "NS"}, {"family": "Vallejo", "given": "Juan", "initials": "J"}, {"family": "van Nuijs", "given": "Alexander", "initials": "A"}, {"family": "Ware", "given": "Vassie", "initials": "V"}, {"family": "Viklander", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-04-22", "journal": {"title": "Water Res", "issn": "1879-2448", "issn-l": "0043-1354", "volume": "199", "issue": null, "pages": "117167"}, "abstract": "The presence of SARS-CoV-2 RNA in wastewater was first reported in March 2020. Over the subsequent months, the potential for wastewater surveillance to contribute to COVID-19 mitigation programmes has been the focus of intense national and international research activities, gaining the attention of policy makers and the public. As a new application of an established methodology, focused collaboration between public health practitioners and wastewater researchers is essential to developing a common understanding on how, when and where the outputs of this non-invasive community-level approach can deliver actionable outcomes for public health authorities. Within this context, the NORMAN SCORE \"SARS-CoV-2 in sewage\" database provides a platform for rapid, open access data sharing, validated by the uploading of 276 data sets from nine countries to-date. Through offering direct access to underpinning meta-data sets (and describing its use in data interpretation), the NORMAN SCORE database is a resource for the development of recommendations on minimum data requirements for wastewater pathogen surveillance. It is also a tool to engage public health practitioners in discussions on use of the approach, providing an opportunity to build mutual understanding of the demand and supply for data and facilitate the translation of this promising research application into public health practice.", "doi": "10.1016/j.watres.2021.117167", "pmid": "34015748", "labels": {"Type: Review": null, "Funder: Vinnova": null}, "xrefs": [{"db": "pii", "key": "S0043-1354(21)00365-1"}], "notes": [], "created": "2021-05-21T17:15:44.041Z", "modified": "2021-05-21T17:24:41.177Z"}, {"entity": "publication", "iuid": "8df82413871348eeb0566de94cc812a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8df82413871348eeb0566de94cc812a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8df82413871348eeb0566de94cc812a0"}}, "title": "Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial.", "authors": [{"family": "Gunst", "given": "Jesper D", "initials": "JD"}, {"family": "Staerke", "given": "Nina B", "initials": "NB"}, {"family": "Pahus", "given": "Marie H", "initials": "MH"}, {"family": "Kristensen", "given": "Lena H", "initials": "LH"}, {"family": "Bodilsen", "given": "Jacob", "initials": "J"}, {"family": "Lohse", "given": "Nicolai", "initials": "N"}, {"family": "Dalgaard", "given": "Lars S", "initials": "LS"}, {"family": "Br\u00f8nnum", "given": "Dorthe", "initials": "D"}, {"family": "Fr\u00f6bert", "given": "Ole", "initials": "O"}, {"family": "H\u00f8nge", "given": "Bo", "initials": "B"}, {"family": "Johansen", "given": "Isik S", "initials": "IS"}, {"family": "Monrad", "given": "Ida", "initials": "I"}, {"family": "Erikstrup", "given": "Christian", "initials": "C"}, {"family": "Rosendal", "given": "Regitze", "initials": "R"}, {"family": "Vilstrup", "given": "Emil", "initials": "E"}, {"family": "Mariager", "given": "Theis", "initials": "T"}, {"family": "Bove", "given": "Dorthe G", "initials": "DG"}, {"family": "Offersen", "given": "Rasmus", "initials": "R"}, {"family": "Shakar", "given": "Shakil", "initials": "S"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "J\u00f8rgensen", "given": "Nis P", "initials": "NP"}, {"family": "Sritharan", "given": "Sajitha S", "initials": "SS"}, {"family": "Breining", "given": "Peter", "initials": "P"}, {"family": "Jespersen", "given": "S\u00f8ren", "initials": "S"}, {"family": "Mortensen", "given": "Klaus L", "initials": "KL"}, {"family": "Jensen", "given": "Mads L", "initials": "ML"}, {"family": "Kolte", "given": "Lilian", "initials": "L"}, {"family": "Frattari", "given": "Giacomo S", "initials": "GS"}, {"family": "Larsen", "given": "Carsten S", "initials": "CS"}, {"family": "Storgaard", "given": "Merete", "initials": "M"}, {"family": "Nielsen", "given": "Lars P", "initials": "LP"}, {"family": "Tolstrup", "given": "Martin", "initials": "M"}, {"family": "S\u00e6dder", "given": "Eva A", "initials": "EA"}, {"family": "\u00d8stergaard", "given": "Lars J", "initials": "LJ"}, {"family": "Ngo", "given": "Hien T T", "initials": "HTT"}, {"family": "Jensen", "given": "Morten H", "initials": "MH"}, {"family": "H\u00f8jen", "given": "Jesper F", "initials": "JF"}, {"family": "Kjolby", "given": "Mads", "initials": "M"}, {"family": "S\u00f8gaard", "given": "Ole S", "initials": "OS"}], "type": "journal article", "published": "2021-04-22", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": null, "issue": null, "pages": "100849", "issn-l": null}, "abstract": "The trans-membrane protease serine 2 (TMPRSS2) is essential for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry and infection. Efficacy and safety of TMPRSS2 inhibitors in patients with coronavirus disease 2019 (Covid-19) have not been evaluated in randomized trials.\n\nWe conducted an investigator-initiated, double-blind, randomized, placebo-controlled multicenter trial in patients hospitalized with confirmed SARS-CoV-2 infection from April 4, to December 31, 2020. Within 48 h of admission, participants were randomly assigned in a 2:1 ratio to receive the TMPRSS2 inhibitor camostat mesilate 200 mg three times daily for 5 days or placebo. The primary outcome was time to discharge or clinical improvement measured as \u22652 points improvement on a 7-point ordinal scale. Other outcomes included 30-day mortality, safety and change in oropharyngeal viral load. ClinicalTrials.gov Identifier: NCT04321096. EudraCT Number: 2020-001,200-42.\n\n137 patients were assigned to receive camostat mesilate and 68 to placebo. Median time to clinical improvement was 5 days (interquartile range [IQR], 3 to 7) in the camostat group and 5 days (IQR, 2 to 10) in the placebo group ( P = 0\u00b731). The hazard ratio for 30-day mortality in the camostat compared with the placebo group was 0\u00b782 (95% confidence interval [CI], 0\u00b724 to 2\u00b779; P = 0\u00b775). The frequency of adverse events was similar in the two groups. Median change in viral load from baseline to day 5 in the camostat group was -0\u00b722 log10 copies/mL (p <0\u00b705) and -0\u00b782 log10 in the placebo group (P <0\u00b705).\n\nUnder this protocol, camostat mesilate treatment was not associated with increased adverse events during hospitalization for Covid-19 and did not affect time to clinical improvement, progression to ICU admission or mortality.", "doi": "10.1016/j.eclinm.2021.100849", "pmid": "33903855", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(21)00129-2"}, {"db": "pmc", "key": "PMC8060682"}, {"db": "ClinicalTrials.gov", "key": "NCT04321096"}], "notes": [], "created": "2021-04-29T10:21:54.594Z", "modified": "2021-04-29T10:22:43.188Z"}, {"entity": "publication", "iuid": "5e8f9500ce5844da856060c74262a286", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e8f9500ce5844da856060c74262a286.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e8f9500ce5844da856060c74262a286"}}, "title": "Clinical outcomes and risk factors for COVID-19 among migrant populations in high-income countries: a systematic review.", "authors": [{"family": "Hayward", "given": "Sally E", "initials": "SE"}, {"family": "Deal", "given": "Anna", "initials": "A"}, {"family": "Cheng", "given": "Cherie", "initials": "C"}, {"family": "Crawshaw", "given": "Alison", "initials": "A"}, {"family": "Orcutt", "given": "Miriam", "initials": "M"}, {"family": "Vandrevala", "given": "Tushna F", "initials": "TF"}, {"family": "Norredam", "given": "Prof Marie", "initials": "PM"}, {"family": "Carballo", "given": "Manuel", "initials": "M"}, {"family": "Ciftci", "given": "Yusuf", "initials": "Y"}, {"family": "Requena-M\u00e9ndez", "given": "Ana", "initials": "A"}, {"family": "Greenaway", "given": "Chris", "initials": "C"}, {"family": "Carter", "given": "Jessica", "initials": "J"}, {"family": "Knights", "given": "Felicity", "initials": "F"}, {"family": "Mehrotra", "given": "Anushka", "initials": "A"}, {"family": "Seedat", "given": "Farah", "initials": "F"}, {"family": "Bozorgmehr", "given": "Prof Kayvan", "initials": "PK"}, {"family": "Veizis", "given": "Apostolos", "initials": "A"}, {"family": "Campos-Matos", "given": "Ines", "initials": "I"}, {"family": "Wurie", "given": "Fatima", "initials": "F"}, {"family": "McKee", "given": "Prof Martin", "initials": "PM"}, {"family": "Kumar", "given": "Prof Bernadette", "initials": "PB"}, {"family": "Hargreaves", "given": "Sally", "initials": "S"}, {"family": "ESCMID Study Group for Infections in Travellers and Migrants (ESGITM)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-04-22", "journal": {"title": "J Migr Health", "issn": "2666-6235", "issn-l": null, "volume": null, "issue": null, "pages": "100041"}, "abstract": "Migrants in high-income countries may be at increased risk of COVID-19 due to their health and social circumstances, yet the extent to which they are affected and their predisposing risk factors are not clearly understood. We did a systematic review to assess clinical outcomes of COVID-19 in migrant populations, indirect health and social impacts, and to determine key risk factors.\r\n\r\nWe did a systematic review following PRISMA guidelines (PROSPERO CRD42020222135). We searched multiple databases to 18/11/2020 for peer-reviewed and grey literature on migrants (foreign-born) and COVID-19 in 82 high-income countries. We used our international networks to source national datasets and grey literature. Data were extracted on primary outcomes (cases, hospitalisations, deaths) and we evaluated secondary outcomes on indirect health and social impacts and risk factors using narrative synthesis.\r\n\r\n3016 data sources were screened with 158 from 15 countries included in the analysis (35 data sources for primary outcomes: cases [21], hospitalisations [4]; deaths [15]; 123 for secondary outcomes). We found that migrants are at increased risk of infection and are disproportionately represented among COVID-19 cases. Available datasets suggest a similarly disproportionate representation of migrants in reported COVID-19 deaths, as well as increased all-cause mortality in migrants in some countries in 2020. Undocumented migrants, migrant health and care workers, and migrants housed in camps have been especially affected. Migrants experience risk factors including high-risk occupations, overcrowded accommodation, and barriers to healthcare including inadequate information, language barriers, and reduced entitlement.\r\n\r\nMigrants in high-income countries are at high risk of exposure to, and infection with, COVID-19. These data are of immediate relevance to national public health and policy responses to the pandemic. Robust data on testing uptake and clinical outcomes in migrants, and barriers and facilitators to COVID-19 vaccination, are urgently needed, alongside strengthening engagement with diverse migrant groups.", "doi": "10.1016/j.jmh.2021.100041", "pmid": "33903857", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2666-6235(21)00008-8"}, {"db": "pmc", "key": "PMC8061095"}], "notes": [], "created": "2021-04-29T10:21:10.252Z", "modified": "2021-07-14T07:44:19.630Z"}, {"entity": "publication", "iuid": "b21b195ee3fb4aa5bf014ac1781bed44", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b21b195ee3fb4aa5bf014ac1781bed44.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b21b195ee3fb4aa5bf014ac1781bed44"}}, "title": "COVID-19 in pregnancy - characteristics and outcomes of pregnant women admitted to hospital because of SARS-CoV-2 infection in the Nordic countries.", "authors": [{"family": "Engjom", "given": "Hilde", "initials": "H"}, {"family": "Aabakke", "given": "Anna Jm", "initials": "AJ"}, {"family": "Klungs\u00f8yr", "given": "Kari", "initials": "K"}, {"family": "Svanvik", "given": "Teresia", "initials": "T"}, {"family": "\u00c4yr\u00e4s", "given": "Outi", "initials": "O"}, {"family": "Jonasdottir", "given": "Eva", "initials": "E"}, {"family": "Thurn", "given": "Lars", "initials": "L"}, {"family": "Jones", "given": "Elin", "initials": "E"}, {"family": "Pettersson", "given": "Karin", "initials": "K"}, {"family": "Nyfl\u00f8t", "given": "Lill Trine", "initials": "LT"}, {"family": "Al-Zirqi", "given": "Iqbal", "initials": "I"}, {"family": "Vangen", "given": "Siri", "initials": "S"}, {"family": "J\u00fal\u00edusson", "given": "P\u00e9tur B", "initials": "PB"}, {"family": "K\u00e4ll\u00e9n", "given": "Karin", "initials": "K"}, {"family": "Gissler", "given": "Mika", "initials": "M"}, {"family": "Krebs", "given": "Lone", "initials": "L"}], "type": "journal article", "published": "2021-04-22", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": null, "issue": null, "issn-l": "0001-6349"}, "abstract": "Population-based studies about the consequences of SARS-CoV-2 infection (COVID-19) in pregnancy are few and have limited generalizability to the Nordic population and health care systems.\n\nThis study examines pregnant women with COVID-19 in the five Nordic countries. Pregnant women were included if they were admitted to hospital between March 1 and June 30, 2020 and had a positive SARS-CoV-2 PCR test 14 days or fewer prior to the admission. Cause of admission was classified as obstetric or COVID-19 related.\n\nIn the study areas, 214 pregnant women with a positive test were admitted to hospital, of which 56 women needed hospital care due to COVID-19. The risk of admission due to COVID-19 was 0.4 per 1000 deliveries in Denmark, Finland, and Norway and 3.8 per 1000 deliveries in the Swedish regions. Women hospitalized because of COVID-19 were more frequently obese (P < 0.001) and had migrant background (P < 0.001) compared to the total population of women who delivered in 2018. Twelve women (21.4%) needed intensive care. Among the 56 women admitted due to COVID-19, 48 women delivered 51 infants. Preterm delivery (n=12, 25%, P < 0.001) and cesarean delivery (n=21, 43,8%, P < 0.001) were more frequent in women with COVID-19 compared to the women who delivered in 2018. No maternal deaths, stillbirths or neonatal deaths were reported.\n\nThe risk of admission due to COVID-19 disease in pregnancy was low in the Nordic countries. A fifth of the women required intensive care and we observed higher rates of preterm and cesarean deliveries. National public health policies appear to have had an impact on the risk of admission due to severe COVID-19 disease in pregnancy. Nordic collaboration is important in collecting robust data and assessing rare outcomes.", "doi": "10.1111/aogs.14160", "pmid": "33885150", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-23T04:26:33.875Z", "modified": "2021-04-23T04:26:33.878Z"}, {"entity": "publication", "iuid": "0eccaa022fbb4b4b9097af6451d6dcfb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0eccaa022fbb4b4b9097af6451d6dcfb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0eccaa022fbb4b4b9097af6451d6dcfb"}}, "title": "The International Academy of Health Sciences Informatics (IAHSI): 2020 Report.", "authors": [{"family": "Haux", "given": "Reinhold", "initials": "R"}, {"family": "Ball", "given": "Marion J", "initials": "MJ"}, {"family": "Hersh", "given": "William R", "initials": "WR"}, {"family": "Huesing", "given": "Elaine", "initials": "E"}, {"family": "Kimura", "given": "Michio", "initials": "M"}, {"family": "Koch", "given": "Sabine", "initials": "S"}, {"family": "Martin-Sanchez", "given": "Fernando", "initials": "F"}, {"family": "Otero", "given": "Paula", "initials": "P"}], "type": "journal article", "published": "2021-04-21", "journal": {"title": "Yearb Med Inform", "issn": "2364-0502", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To summarize the major activities of the International Academy of Health Sciences Informatics (IAHSI) in the 2020 time period and to welcome its 2020 Class of Fellows.\r\n\r\nReport from the members of the Academy's Board.\r\n\r\nDue to the SARS-CoV-2 pandemic, both Plenary meetings in 2020 had to be organized as virtual meetings. Scientific discussions, focusing on mobilizing computable biomedical knowledge and on data standards and interoperability formed major parts of these meetings. A statement on the use of informatics in pandemic situations was elaborated and sent to the World Health Organization. A panel on data standards and interoperability started its work. 34 Fellows were welcomed in the 2020 Class of Fellows so that the Academy now consists of 179 members.\r\n\r\nThere was a shift from supporting to strategic activities in the Academy's work. After having achieved organizational stability, the Academy can now focus on its strategic work and so on its main objective.", "doi": "10.1055/s-0041-1726479", "pmid": "33882593", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-04-23T04:37:32.554Z", "modified": "2021-07-14T07:42:34.648Z"}, {"entity": "publication", "iuid": "58dc6579e3f346f29a8468c2230d99ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/58dc6579e3f346f29a8468c2230d99ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/58dc6579e3f346f29a8468c2230d99ca"}}, "title": "Opportunities and Challenges for the Next Phase of Enhanced Recovery After Surgery: A Review.", "authors": [{"family": "Ljungqvist", "given": "Olle", "initials": "O"}, {"family": "de Boer", "given": "Hans D", "initials": "HD"}, {"family": "Balfour", "given": "Angie", "initials": "A"}, {"family": "Fawcett", "given": "William J", "initials": "WJ"}, {"family": "Lobo", "given": "Dileep N", "initials": "DN"}, {"family": "Nelson", "given": "Gregg", "initials": "G"}, {"family": "Scott", "given": "Michael J", "initials": "MJ"}, {"family": "Wainwright", "given": "Thomas W", "initials": "TW"}, {"family": "Demartines", "given": "Nicolas", "initials": "N"}], "type": "journal article", "published": "2021-04-21", "journal": {"title": "JAMA Surg", "issn": "2168-6262", "volume": null, "issue": null, "issn-l": null}, "abstract": "Enhanced Recovery After Surgery (ERAS) is a global surgical quality improvement initiative now firmly entrenched within the field of perioperative care. Although ERAS is associated with significant clinical outcome improvements and cost savings in numerous surgical specialties, several opportunities and challenges deserve further discussion.\n\nUptake and implementation of ERAS Society guidelines, together with ERAS-related research, have increased exponentially since the inception of the ERAS movement. Opportunities to further improve patient outcomes include addressing frailty, optimizing nutrition, prehabilitation, correcting preoperative anemia, and improving uptake of ERAS worldwide, including in low- and middle-income countries. Challenges facing enhanced recovery today include implementation, carbohydrate loading, reversal of neuromuscular blockade, and bowel preparation. The COVID-19 pandemic poses both a challenge and an opportunity for ERAS.\n\nTo date, ERAS has achieved significant benefit for patients and health systems; however, improvements are still needed, particularly in the areas of patient optimization and systematic implementation. During this time of global crisis, the ERAS method of delivering care is required to take surgery and anesthesia to the next level and bring improvements in outcomes to both patients and health systems.", "doi": "10.1001/jamasurg.2021.0586", "pmid": "33881466", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "2778928"}], "notes": [], "created": "2021-04-23T04:39:04.745Z", "modified": "2021-04-23T04:39:04.767Z"}, {"entity": "publication", "iuid": "2531ed7bcaaa4d80b39e4f02c542c107", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2531ed7bcaaa4d80b39e4f02c542c107.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2531ed7bcaaa4d80b39e4f02c542c107"}}, "title": "Enhancing Safety During a Pandemic Using Virtual Care Remote Monitoring Technologies and UML Modeling.", "authors": [{"family": "Borycki", "given": "Elizabeth M", "initials": "EM"}, {"family": "Kushniruk", "given": "Andre W", "initials": "AW"}, {"family": "Kletke", "given": "Ryan", "initials": "R"}, {"family": "Vimarlund", "given": "Vivian", "initials": "V"}, {"family": "Senathirajah", "given": "Yalini", "initials": "Y"}, {"family": "Quintana", "given": "Yuri", "initials": "Y"}], "type": "journal article", "published": "2021-04-21", "journal": {"title": "Yearb Med Inform", "issn": "2364-0502", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "This paper describes a methodology for gathering requirements and early design of remote monitoring technology (RMT) for enhancing patient safety during pandemics using virtual care technologies. As pandemics such as COrona VIrus Disease (COVID-19) progress there is an increasing need for effective virtual care and RMT to support patient care while they are at home.\r\n\r\nThe authors describe their work in conducting literature reviews by searching PubMed.gov and the grey literature for articles, and government websites with guidelines describing the signs and symptoms of COVID-19, as well as the progression of the disease. The reviews focused on identifying gaps where RMT could be applied in novel ways and formed the basis for the subsequent modelling of use cases for applying RMT described in this paper.\r\n\r\nThe work was conducted in the context of a new Home of the Future laboratory which has been set up at the University of Victoria. The literature review led to the development of a number of object-oriented models for deploying RMT. This modeling is being used for a number of purposes, including for education of students in health infomatics as well as testing of new use cases for RMT with industrial collaborators and projects within the smart home of the future laboratory.\r\n\r\nObject-oriented modeling, based on analysis of gaps in the literature, was found to be a useful approach for describing, communicating and teaching about potential new uses of RMT.", "doi": "10.1055/s-0041-1726485", "pmid": "33882599", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-04-23T04:35:17.857Z", "modified": "2021-07-14T07:40:56.626Z"}, {"entity": "publication", "iuid": "c36b83f5047b46e28e2c5e70b287efd5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c36b83f5047b46e28e2c5e70b287efd5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c36b83f5047b46e28e2c5e70b287efd5"}}, "title": "Colorimetric isothermal nucleic acid detection of SARS-CoV-2 with dye combination.", "authors": [{"family": "Wu", "given": "Shanshan", "initials": "S"}, {"family": "Liu", "given": "Xiyang", "initials": "X"}, {"family": "Ye", "given": "Shenglong", "initials": "S"}, {"family": "Liu", "given": "Jianmin", "initials": "J"}, {"family": "Zheng", "given": "Wei", "initials": "W"}, {"family": "Dong", "given": "Xue", "initials": "X"}, {"family": "Yin", "given": "Xiushan", "initials": "X"}], "type": "journal article", "published": "2021-04-21", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": null, "issue": null, "pages": "e06886", "issn-l": null}, "abstract": "RT-LAMP detection of SARS-CoV-2 has been demonstrated to be a valuable diagnostic method for the diagnosis of COVID-19 1,2, which can rapidly screen carriers of the virus to effectively control the spread of the SARS-CoV-2. Here, we present a combination of dyes for isothermal detection of SARS-CoV-2 as a commercial alternative, with expanded colorimetric spectrum. We compared them with commercial reagents and proved their suitability and sensitivity through clinical RNA samples. In addition, together with commercial single dye indicators, we believe the expanded color spectrum developed here as an indicator of rapid detection will promote the diagnosis of COVID-19.", "doi": "10.1016/j.heliyon.2021.e06886", "pmid": "33903853", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)00989-0"}, {"db": "pmc", "key": "PMC8059943"}], "notes": [], "created": "2021-04-29T10:24:05.235Z", "modified": "2021-04-29T10:24:05.246Z"}, {"entity": "publication", "iuid": "a1dd881e061043cdbf6c5d279d0cd195", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a1dd881e061043cdbf6c5d279d0cd195.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a1dd881e061043cdbf6c5d279d0cd195"}}, "title": "Utilization of traditional medicine and its integration into the healthcare system in Qokolweni, South Africa; prospects for enhanced universal health coverage.", "authors": [{"family": "Mutola", "given": "Sianga", "initials": "S"}, {"family": "Pemunta", "given": "Ngambouk Vitalis", "initials": "NV"}, {"family": "Ngo", "given": "Ngo Valery", "initials": "NV"}], "type": "journal article", "published": "2021-04-20", "journal": {"title": "Complement Ther Clin Pract", "issn": "1873-6947", "issn-l": null, "volume": "43", "issue": null, "pages": "101386"}, "abstract": "Despite the WHO providing a framework for the integration of traditional medicines into the health systems with pandemics like HIV/AIDS and the COVID-19, most countries are yet to adopt the recommendations. This study explored why the integration of traditional medicines with the biomedical healthcare system in Qokolweni in Eastern Cape, South Africa was stalling. The research employed qualitative research methods; participant observation and in-depth ethnographic interviews of community members, traditional healers, and nurses. The study found that: traditional medicines are widely used in Qokolweni due to accessibility and long-built trust; the practice is broad and not certified. To achieve the integration of traditional medicine into the conventional health systems, the central government needs to show political will by setting up regulatory strategies that provide for the scientific evaluation and certification of traditional medicines. This will build confidence among biomedical scientists and health practitioners, thereby fostering easy collaboration and integration.", "doi": "10.1016/j.ctcp.2021.101386", "pmid": "33895465", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1744-3881(21)00085-2"}], "notes": [], "created": "2021-04-29T15:27:43.729Z", "modified": "2021-07-14T07:35:30.273Z"}, {"entity": "publication", "iuid": "0ca0ff0b36104042b3ab3ee645154f46", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ca0ff0b36104042b3ab3ee645154f46.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ca0ff0b36104042b3ab3ee645154f46"}}, "title": "SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses.", "authors": [{"family": "Mandolesi", "given": "Marco", "initials": "M"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Ma", "given": "Junjie", "initials": "J"}, {"family": "Pushparaj", "given": "Pradeepa", "initials": "P"}, {"family": "Perez Vidakovics", "given": "Laura", "initials": "L"}, {"family": "Kim", "given": "Changil", "initials": "C"}, {"family": "\u00c0dori", "given": "Monika", "initials": "M"}, {"family": "Lenart", "given": "Klara", "initials": "K"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "Castro Dopico", "given": "Xaquin", "initials": "X"}, {"family": "Coquet", "given": "Jonathan M", "initials": "JM"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Murrell", "given": "Ben", "initials": "B"}], "type": "journal article", "published": "2021-04-20", "journal": {"title": "Cell Rep Med", "issn": "2666-3791", "issn-l": "2666-3791", "volume": "2", "issue": "4", "pages": "100252"}, "abstract": "The outbreak and spread of SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2) is a current global health emergency, and effective prophylactic vaccines are needed urgently. The spike glycoprotein of SARS-CoV-2 mediates entry into host cells, and thus is the target of neutralizing antibodies. Here, we show that adjuvanted protein immunization with soluble SARS-CoV-2 spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaques, with neutralizing antibody titers exceeding those typically measured in SARS-CoV-2 seropositive humans by more than one order of magnitude. Neutralizing antibody responses were observed after a single dose, with exceptionally high titers achieved after boosting. A follow-up to monitor the waning of the neutralizing antibody responses in rhesus macaques demonstrated durable responses that were maintained at high and stable levels at least 4 months after boosting. These data support the development of adjuvanted SARS-CoV-2 prefusion-stabilized spike protein subunit vaccines.", "doi": "10.1016/j.xcrm.2021.100252", "pmid": "33842900", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Funder: H2020": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S2666-3791(21)00068-9"}, {"db": "pmc", "key": "PMC8020888"}], "notes": [], "created": "2021-04-13T09:35:47.773Z", "modified": "2021-09-27T12:29:50.595Z"}, {"entity": "publication", "iuid": "a05ae0b55843422eb39e3a7ea4e21182", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a05ae0b55843422eb39e3a7ea4e21182.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a05ae0b55843422eb39e3a7ea4e21182"}}, "title": "Internet-Related Behaviors and Psychological Distress Among Schoolchildren During the COVID-19 School Hiatus", "authors": [{"family": "Chen", "given": "Chao Ying", "initials": "CY"}, {"family": "Chen", "given": "I Hua", "initials": "IH"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Lin", "given": "Chung Ying", "initials": "CY"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}], "type": "journal-article", "published": "2021-04-20", "journal": {"title": "Cyberpsychology, Behavior, and Social Networking", "issn": "2152-2715", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1089/cyber.2020.0497", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-04-23T04:41:04.022Z", "modified": "2021-04-23T04:41:04.044Z"}, {"entity": "publication", "iuid": "6635da3d214446ccba6addfe21442f84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6635da3d214446ccba6addfe21442f84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6635da3d214446ccba6addfe21442f84"}}, "title": "Cell type resolved quantitative proteomics map of interferon response against SARS-CoV-2.", "authors": [{"family": "Saccon", "given": "Elisa", "initials": "E"}, {"family": "Chen", "given": "Xi", "initials": "X"}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "Rodriguez", "given": "Jimmy Esneider", "initials": "JE"}, {"family": "Szekely", "given": "Laszlo", "initials": "L"}, {"family": "Vinhas", "given": "Beatriz S\u00e1", "initials": "BS"}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}, {"family": "Frisan", "given": "Teresa", "initials": "T"}, {"family": "V\u00e9gv\u00e1ri", "given": "\u00c1kos", "initials": "\u00c1"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}, {"family": "Gupta", "given": "Soham", "initials": "S"}], "type": "journal article", "published": "2021-04-20", "journal": {"title": "iScience", "issn": "2589-0042", "issn-l": "2589-0042", "volume": "24", "issue": "5", "pages": "102420"}, "abstract": "The commonly used laboratory cell lines are the first line of experimental models to study the pathogenicity and performing antiviral assays for emerging viruses. Here, we assessed the tropism and cytopathogenicity of the first Swedish isolate of SARS-CoV-2 in six different human cell lines, compared their growth characteristics and performed quantitative proteomics for the susceptible cell lines. Overall, Calu-3, Caco2, Huh7, and 293FT cell lines showed a high to moderate level of susceptibility to SARS-CoV-2. In Caco2 cells the virus can achieve high titers in the absence of any prominent cytopathic effect. The protein abundance profile during SARS-CoV-2 infection revealed cell-type-specific regulation of cellular pathways. Type-I interferon signaling was identified as the common dysregulated cellular response in Caco2, Calu-3 and Huh7 cells. Together, our data shows cell-type specific variability for cytopathogenicity, susceptibility and cellular response to SARS-CoV-2 and provide important clues to guide future studies.", "doi": "10.1016/j.isci.2021.102420", "pmid": "33898942", "labels": {"Type: Journal article": null, "Funder: H2020": null, "Funder: VR": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(21)00388-6"}, {"db": "pmc", "key": "PMC8056843"}], "notes": [], "created": "2021-04-29T10:27:34.511Z", "modified": "2021-08-25T14:31:17.789Z"}, {"entity": "publication", "iuid": "7aa42797dd3049668c25bbdafe828ba2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7aa42797dd3049668c25bbdafe828ba2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7aa42797dd3049668c25bbdafe828ba2"}}, "title": "COVID-19 as the sole cause of death is uncommon in frail home healthcare individuals: a population-based study.", "authors": [{"family": "Nilsson", "given": "Lena", "initials": "L"}, {"family": "Andersson", "given": "Christer", "initials": "C"}, {"family": "Sj\u00f6dahl", "given": "Rune", "initials": "R"}], "type": "journal article", "published": "2021-04-20", "journal": {"title": "BMC Geriatr", "issn": "1471-2318", "issn-l": null, "volume": "21", "issue": "1", "pages": "262"}, "abstract": "During the first pandemic wave, Sweden experienced a high mortality rate. Home healthcare reflects a group of people especially vulnerable to coronavirus disease 2019 (COVID-19). We aimed to evaluate the pattern of comorbidity and frailty in a group of individuals having fatal outcomes in home healthcare during the COVID-19 pandemic March to September 2020, and to assess the contribution of COVID-19 in the fatal outcomes.\r\n\r\nA cohort of adults with confirmed COVID-19 diagnosis that deceased in home healthcare between March and September 2020 were analysed in a retrospective study comprising home healthcare in 136 facilities in one Swedish county. Main outcome measures were comorbidity and frailty.\r\n\r\nOne hundred fifty-five individuals (88 women, 67 men) aged 57-106 (median 88) years were included in the analysis. Nine had considerable frailty (ability to perform various activities of daily living but confined to bed or chair on occasion) and the remaining 146 had severe frailty (unable to perform activities of daily living and/or confined to bed or chair; dementia necessitating care). Three or more diagnoses besides COVID-19 were present in 142 individuals and another eight had two diagnoses in addition to COVID-19. In 20 (13%) individuals, COVID-19 was assessed as the principal cause of death, in 100 (64.5%) a contributing cause, and for the remaining 35 (22.5%) death was probably caused by another comorbidity. This seemed to change over the course of the COVID - 19 pandemic, with its contributing role decreasing from the middle of the summer.\r\n\r\nDeath in home healthcare during the first wave of the pandemic mostly affected individuals with severe frailty and comorbidity at very advanced ages. One fifth of the individuals who died in home health care had another cause than Covid-19.\r\n\r\nClinical Trials.gov NCT04642196 date 24/11/2020.", "doi": "10.1186/s12877-021-02176-z", "pmid": "33879078", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12877-021-02176-z"}, {"db": "ClinicalTrials.gov", "key": "NCT04642196"}], "notes": [], "created": "2021-04-23T04:39:25.834Z", "modified": "2021-07-14T07:38:36.859Z"}, {"entity": "publication", "iuid": "7b8ac0478dd64503b3ce0f6d32c35cfa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b8ac0478dd64503b3ce0f6d32c35cfa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b8ac0478dd64503b3ce0f6d32c35cfa"}}, "title": "COVID-19 and municipal solid waste (MSW) management: a review", "authors": [{"family": "Das", "given": "Atanu Kumar", "initials": "AK"}, {"family": "Islam", "given": "Md Nazrul", "initials": "MN"}, {"family": "Billah", "given": "Md Morsaline", "initials": "MM"}, {"family": "Sarker", "given": "Asim", "initials": "A"}], "type": "journal-article", "published": "2021-04-20", "journal": {"title": "Environ Sci Pollut Res", "issn": "0944-1344", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1007/s11356-021-13914-6", "pmid": null, "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-04-23T04:42:33.639Z", "modified": "2021-04-23T04:42:33.662Z"}, {"entity": "publication", "iuid": "71f835534d1d490792921196d40f951a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/71f835534d1d490792921196d40f951a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/71f835534d1d490792921196d40f951a"}}, "title": "A Multi-Criteria Framework for Pandemic Response Measures.", "authors": [{"family": "Ekenberg", "given": "Love", "initials": "L"}, {"family": "Mihai", "given": "Adriana", "initials": "A"}, {"family": "Fasth", "given": "Tobias", "initials": "T"}, {"family": "Komendantova", "given": "Nadejda", "initials": "N"}, {"family": "Danielson", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2021-04-20", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "issue": null, "pages": "583706", "issn-l": "2296-2565"}, "abstract": "In managing the COVID-19 pandemic, several compelling narratives seem to have played a significant role in the decision-making processes regarding which risk mitigation and management measures to implement. Many countries were to a large extent unprepared for such a situation, even though predictions about a significant probability for a pandemic to occur existed, and national governments of several countries often acted in an uncoordinated manner, which resulted in many inconsistencies in the disaster risk reduction processes. Limited evidence has also made room for strategic narratives meant to persuade the public of the chosen set of actions, even though the degree of uncertainty regarding the outcomes of these was high, further complicating the situation. In this article, we assume a normative standpoint regarding rhapsodic decision making and suggest an integrated framework for a more elaborated decision analysis under the ambiguity of how to contain the virus spread from a policy point of view, while considering epidemiologic estimations and socioeconomic factors in a multi-stakeholder-multi-criteria context based on a co-creative work process for eliciting attitudes, perceptions, as well as preferences amongst relevant stakeholder groups. The framework, applied in our paper on Romania for demonstrative purposes, is used for evaluating mitigation measures for catastrophic events such as the COVID-19 situation, to mobilize better response strategies for future scenarios related to pandemics and other hazardous events, as well as to structure the production and analysis of narratives on the current pandemic effects.", "doi": "10.3389/fpubh.2021.583706", "pmid": "33968871", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8096778"}], "notes": [], "created": "2021-05-17T19:03:26.840Z", "modified": "2021-05-17T19:03:26.852Z"}, {"entity": "publication", "iuid": "27ead992a7654577962986e6513c266b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27ead992a7654577962986e6513c266b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27ead992a7654577962986e6513c266b"}}, "title": "The Impact of Coronavirus (COVID-19) Related Public-Health Measures on Training Behaviours of Individuals Previously Participating in Resistance Training: A Cross-Sectional Survey Study", "authors": [{"family": "Steele", "given": "James", "initials": "J"}, {"family": "Androulakis-Korakakis", "given": "Patroklos", "initials": "P"}, {"family": "Carlson", "given": "Luke", "initials": "L"}, {"family": "Williams", "given": "David", "initials": "D"}, {"family": "Phillips", "given": "Stuart", "initials": "S"}, {"family": "Smith", "given": "Dave", "initials": "D"}, {"family": "Schoenfeld", "given": "Brad J", "initials": "BJ"}, {"family": "Loenneke", "given": "Jeremy P", "initials": "JP"}, {"family": "Winett", "given": "Richard", "initials": "R"}, {"family": "Abe", "given": "Takashi", "initials": "T"}, {"family": "Dufour", "given": "St\u00e9phane", "initials": "S"}, {"family": "Franchi", "given": "Martino V", "initials": "MV"}, {"family": "Sarto", "given": "Fabio", "initials": "F"}, {"family": "Lundberg", "given": "Tommy R", "initials": "TR"}, {"family": "Gentil", "given": "Paulo", "initials": "P"}, {"family": "Kvorning", "given": "Thue", "initials": "T"}, {"family": "Giessing", "given": "J\u00fcrgen", "initials": "J"}, {"family": "Sedliak", "given": "Milan", "initials": "M"}, {"family": "Paoli", "given": "Antonio", "initials": "A"}, {"family": "Spotswood", "given": "Fiona", "initials": "F"}, {"family": "Lucas", "given": "Alex", "initials": "A"}, {"family": "Fisher", "given": "James P", "initials": "JP"}], "type": "journal-article", "published": "2021-04-19", "journal": {"title": "Sports Med", "issn": "1179-2035", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": "Understanding the impact of lockdown upon resistance training (RT), and how people adapted their RT behaviours, has implications for strategies to maintain engagement in similar positive health behaviours. Further, doing so will provide a baseline for investigation of the long-term effects of these public health measures upon behaviours and perceptions, and facilitate future follow-up study.\r\n\r\nTo determine how the onset of coronavirus (COVID-19), and associated 'lockdown', affected RT behaviours, in addition to motivation, perceived effectiveness, enjoyment, and intent to continue, in those who regularly performed RT prior to the pandemic.\r\n\r\nWe conducted an observational, cross-sectional study using online surveys in multiple languages (English, Danish, French, German, Italian, Portuguese, Slovakian, Swedish, and Japanese) distributed across social media platforms and through authors' professional and personal networks. Adults (n = 5389; median age = 31 years [interquartile range (IQR) = 25, 38]), previously engaged in RT prior to lockdown (median prior RT experience = 7 years [IQR = 4, 12]) participated. Outcomes were self-reported RT behaviours including: continuation of RT during lockdown, location of RT, purchase of specific equipment for RT, method of training, full-body or split routine, types of training, repetition ranges, exercise number, set volumes (per exercise and muscle group), weekly frequency of training, perception of effort, whether training was planned/recorded, time of day, and training goals. Secondary outcomes included motivation, perceived effectiveness, enjoyment, and intent to continue RT.\r\n\r\nA majority of individuals (82.8%) maintained participation in RT during-lockdown. Marginal probabilities from generalised linear models and generalised estimating equations for RT behaviours were largely similar from pre- to during-lockdown. There was reduced probability of training in privately owned gyms (~ 59% to ~ 7%) and increased probability of training at home (~ 18% to ~ 89%); greater probability of training using a full-body routine (~ 38% to ~ 51%); reduced probability of resistance machines (~ 66% to ~ 13%) and free weight use (~ 96% to ~ 81%), and increased probability of bodyweight training (~ 62% to ~ 82%); reduced probability of moderate repetition ranges (~ 62-82% to ~ 55-66%) and greater probability of higher repetition ranges (~ 27% to ~ 49%); and moderate reduction in the perception of effort experienced during-training (r = 0.31). Further, individuals were slightly less likely to plan or record training during lockdown and many changed their training goals. Additionally, perceived effectiveness, enjoyment, and likelihood of continuing current training were all lower during-lockdown.\r\n\r\nThose engaged in RT prior to lockdown these behaviours with only slight adaptations in both location and types of training performed. However, people employed less effort, had lower motivation, and perceived training as less effective and enjoyable, reporting their likelihood of continuing current training was similar or lower than pre-lockdown. These results have implications for strategies to maintain engagement in positive health behaviours such as RT during-restrictive pandemic-related public health measures. PRE-REGISTRATION: https://osf.io/qcmpf .\r\n\r\nThe preprint version of this work is available on SportR\u03c7iv: https://osf.io/preprints/sportrxiv/b8s7e/ .", "doi": "10.1007/s40279-021-01438-5", "pmid": "33871831", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "URL", "key": "https://osf.io/xhryf/", "description": "Dataset: Survey data"}], "notes": [], "created": "2021-04-20T17:54:09.535Z", "modified": "2021-07-14T10:59:51.720Z"}, {"entity": "publication", "iuid": "104de2c0ff24467faa96e866ae338d06", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/104de2c0ff24467faa96e866ae338d06.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/104de2c0ff24467faa96e866ae338d06"}}, "title": "ECG with Prior Myocardial Infarction Pattern or acute ST-T Pathology is Associated with Death in Critically Ill COVID-19 Patients", "authors": [{"family": "Rosen", "given": "Jacob", "initials": "J"}, {"family": "Noreland", "given": "Maria", "initials": "M"}, {"family": "Stattin", "given": "Karl", "initials": "K"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Malinovschi", "given": "Andrei", "initials": "A"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}], "type": "posted-content", "published": "2021-04-19", "journal": {"title": "Research Square", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.21203/rs.3.rs-419853/v1", "pmid": null, "labels": {"Funder: VR": null, "Type: Preprint": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.17044/scilifelab.14229410.v1", "description": "Metadata record"}], "notes": [], "created": "2021-06-09T12:05:22.522Z", "modified": "2021-06-18T09:19:34.572Z"}, {"entity": "publication", "iuid": "3840116225c543e5a738388f958bb923", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3840116225c543e5a738388f958bb923.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3840116225c543e5a738388f958bb923"}}, "title": "Cause of death based on systematic postmortem studies in patients with positive SARS\u2010CoV2 tissue PCR during the COVID\u201019 pandemic", "authors": [{"family": "Romanova", "given": "Elena S", "initials": "ES"}, {"family": "Vasilyev", "given": "Valery V", "initials": "VV"}, {"family": "Startseva", "given": "Galina", "initials": "G"}, {"family": "Karev", "given": "Vadim", "initials": "V"}, {"family": "Rybakova", "given": "Margarita G", "initials": "MG"}, {"family": "Platonov", "given": "Pyotr G", "initials": "PG"}], "type": "journal-article", "published": "2021-04-19", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1111/joim.13300", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-20T17:53:20.904Z", "modified": "2021-04-20T17:53:20.921Z"}, {"entity": "publication", "iuid": "38bb5376ea5b44bea12092dbca89831b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38bb5376ea5b44bea12092dbca89831b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38bb5376ea5b44bea12092dbca89831b"}}, "title": "Why COVID-19 strengthens the case to scale up assault on non-communicable diseases: role of health professionals including physical therapists in mitigating pandemic waves.", "authors": [{"family": "Dean", "given": "Elizabeth", "initials": "E"}, {"family": "Skinner", "given": "Margot", "initials": "M"}, {"family": "Yu", "given": "Homer Peng-Ming", "initials": "HP"}, {"family": "Jones", "given": "Alice Ym", "initials": "AY"}, {"family": "Gosselink", "given": "Rik", "initials": "R"}, {"family": "S\u00f6derlund", "given": "Anne", "initials": "A"}], "type": "journal article", "published": "2021-04-16", "journal": {"title": "AIMS Public Health", "issn": "2327-8994", "volume": "8", "issue": "2", "pages": "369-375", "issn-l": null}, "abstract": "As SARS-CoV-2, the virus responsible for COVID-19, spread globally, the most severely affected sub-populations were the elderly and those with multi-morbidity largely related to non-communicable diseases (NCDs), e.g., heart disease, hypertension, type 2 diabetes, obesity. NCDs are largely preventable with healthy nutrition, regular activity, and not smoking. This perspective outlines the rationale for health professionals' including physical therapists' role in reducing COVID-19 susceptibility. Evidence is synthesized supporting the pro-inflammatory effects of the western diet, increasingly consumed globally, inactivity, and smoking; and the immune-boosting, anti-inflammatory effects of a whole food plant-based diet, regular physical activity, and not smoking. An increased background of chronic low-grade systemic inflammation associated with unhealthy lifestyle practices appears implicated in an individual's susceptibility to SARS-CoV-2. It is timely to re-double efforts across healthcare sectors to reduce the global prevalence of NCDs on two fronts: one, to reduce SARS-CoV-2 susceptibility; and two, to reduce the impact of subsequent waves given high blood pressure and blood sugar, common in people with multi-morbidity, can be improved within days/weeks with anti-inflammatory healthy lifestyle practices, and weight loss and atherosclerosis reduction/reversal, within months/years. With re-doubled efforts to control NCD risk factors, subsequent waves could be less severe. Health professionals including physical therapists have a primary role in actively leading this initiative.", "doi": "10.3934/publichealth.2021028", "pmid": "34017898", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "publichealth-08-02-028"}, {"db": "pmc", "key": "PMC8116194"}], "notes": [], "created": "2021-05-29T16:25:31.820Z", "modified": "2021-05-29T16:25:31.843Z"}, {"entity": "publication", "iuid": "f3ad0ee0464842b3ae6ef3b029d00a7f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f3ad0ee0464842b3ae6ef3b029d00a7f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f3ad0ee0464842b3ae6ef3b029d00a7f"}}, "title": "Vaccination against COVID-19: insight from arterial and venous thrombosis occurrence using data from VigiBase.", "authors": [{"family": "Smadja", "given": "David M", "initials": "DM"}, {"family": "Yue", "given": "Qun-Ying", "initials": "Q"}, {"family": "Chocron", "given": "Richard", "initials": "R"}, {"family": "Sanchez", "given": "Olivier", "initials": "O"}, {"family": "Lillo-Le Louet", "given": "Agnes", "initials": "A"}], "type": "letter", "published": "2021-04-16", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "issn-l": "0903-1936", "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1183/13993003.00956-2021", "pmid": "33863748", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "13993003.00956-2021"}], "notes": [], "created": "2021-04-19T10:39:09.176Z", "modified": "2021-04-29T16:33:21.674Z"}, {"entity": "publication", "iuid": "066372348ae8499fa8e4633f559b0634", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/066372348ae8499fa8e4633f559b0634.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/066372348ae8499fa8e4633f559b0634"}}, "title": "Continuous renal replacement therapy in intensive care patients with COVID-19; survival and renal recovery.", "authors": [{"family": "Eriksson", "given": "Karin E", "initials": "KE"}, {"family": "Campoccia-Jalde", "given": "Francesca", "initials": "F"}, {"family": "Rysz", "given": "Susanne", "initials": "S"}, {"family": "Rimes-Stigare", "given": "Claire", "initials": "C"}], "type": "journal article", "published": "2021-04-16", "journal": {"title": "J Crit Care", "issn": "1557-8615", "volume": "64", "issue": null, "pages": "125-130", "issn-l": "0883-9441"}, "abstract": "Outcome for critically ill patients with COVID-19 treated with continuous renal replacement therapy (CRRT) is largely unknown. We describe mortality and renal outcome in this group.\n\nThis observational study was conducted at a university hospital in Sweden. We studied critically ill adult COVID-19 patients with Acute Kidney injury (AKI) who received CRRT.\n\nIn 451 patients, AKI incidence was 43.7%. 18.2% received CRRT. Median age of CRRT patients was 60 years (IQR 54-65), 90% were male, median BMI was 29 (IQR 25-32), 23.2% had Diabetes, 37.8% hypertension and 6.1% chronic kidney disease prior to admission. 100% required mechanical ventilation. 8.5% received Extra Corporeal Membrane Oxygenation. Median length of stay was 23 days (IQR 15-26). ICU mortality was 39% and 90-day mortality was 45.1%. Age, baseline creatinine values and body weight change were associated with 60 days mortality. Of the survivors, no patients required dialysis at hospital discharge, 73.8% recovered renal function and a median 10.5% of body weight was lost during admission.\n\nCritically ill COVID-19 patients with AKI who received CRRT had a 90-day mortality of 45.1%. At follow-up, three quarters of survivors had recovered renal function. This information is important in the clinical management of COVID-19.", "doi": "10.1016/j.jcrc.2021.04.002", "pmid": "33878517", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0883-9441(21)00063-0"}, {"db": "pmc", "key": "PMC8052481"}], "notes": [], "created": "2021-04-23T04:40:30.388Z", "modified": "2021-04-23T04:40:30.399Z"}, {"entity": "publication", "iuid": "043e3c05fce449a0986615c8f2b88cd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/043e3c05fce449a0986615c8f2b88cd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/043e3c05fce449a0986615c8f2b88cd0"}}, "title": "Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials.", "authors": [{"family": "Axfors", "given": "Cathrine", "initials": "C"}, {"family": "Schmitt", "given": "Andreas M", "initials": "AM", "orcid": "0000-0002-9568-8164", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e04ff63fee604c08bb913012e4645bf6.json"}}, {"family": "Janiaud", "given": "Perrine", "initials": "P"}, {"family": "Van't Hooft", "given": "Janneke", "initials": "J", "orcid": "0000-0001-5303-1503", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d0cd2d5d4ae4c88bf5b3307e32869a8.json"}}, {"family": "Abd-Elsalam", "given": "Sherief", "initials": "S", "orcid": "0000-0003-4366-2218", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fb051b677594bbca20b5637fc0420a9.json"}}, {"family": "Abdo", "given": "Ehab F", "initials": "EF", "orcid": "0000-0002-9805-3850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04cb35857c4b46829ebb73f25fad291a.json"}}, {"family": "Abella", "given": "Benjamin S", "initials": "BS", "orcid": "0000-0003-2521-0891", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7572ea9966aa4951afd5d2490960148e.json"}}, {"family": "Akram", "given": "Javed", "initials": "J"}, {"family": "Amaravadi", "given": "Ravi K", "initials": "RK"}, {"family": "Angus", "given": "Derek C", "initials": "DC"}, {"family": "Arabi", "given": "Yaseen M", "initials": "YM"}, {"family": "Azhar", "given": "Shehnoor", "initials": "S"}, {"family": "Baden", "given": "Lindsey R", "initials": "LR"}, {"family": "Baker", "given": "Arthur W", "initials": "AW", "orcid": "0000-0002-0914-0291", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51dd5ed5fb784143955e3c7e587b7014.json"}}, {"family": "Belkhir", "given": "Leila", "initials": "L"}, {"family": "Benfield", "given": "Thomas", "initials": "T", "orcid": "0000-0003-0698-9385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a335d1a321c46b2a0ba4f80dc3d93b4.json"}}, {"family": "Berrevoets", "given": "Marvin A H", "initials": "MAH"}, {"family": "Chen", "given": "Cheng-Pin", "initials": "CP", "orcid": "0000-0002-0629-9790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/773f850e035a47269048204713babe5f.json"}}, {"family": "Chen", "given": "Tsung-Chia", "initials": "TC", "orcid": "0000-0002-3461-5535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2df09990f13243b6a7d586e65808f9a5.json"}}, {"family": "Cheng", "given": "Shu-Hsing", "initials": "SH", "orcid": "0000-0002-6256-0527", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44efc129a6a54e9a85422a2c1122c047.json"}}, {"family": "Cheng", "given": "Chien-Yu", "initials": "CY"}, {"family": "Chung", "given": "Wei-Sheng", "initials": "WS", "orcid": "0000-0003-4240-5690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79973df7d6b94b529a779c7b3d1bc471.json"}}, {"family": "Cohen", "given": "Yehuda Z", "initials": "YZ", "orcid": "0000-0001-6987-1478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3839874cc0f4a91a69d0fb2fc15c35a.json"}}, {"family": "Cowan", "given": "Lisa N", "initials": "LN"}, {"family": "Dalgard", "given": "Olav", "initials": "O"}, {"family": "de Almeida E Val", "given": "Fernando F", "initials": "FF"}, {"family": "de Lacerda", "given": "Marcus V G", "initials": "MVG", "orcid": "0000-0003-3374-9985", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5df56fcaab5d4fbea3ee4a973b3ed44f.json"}}, {"family": "de Melo", "given": "Gisely C", "initials": "GC"}, {"family": "Derde", "given": "Lennie", "initials": "L", "orcid": "0000-0002-3577-5629", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cdd814a355e486a88cb134b060427bc.json"}}, {"family": "Dubee", "given": "Vincent", "initials": "V", "orcid": "0000-0002-9982-4741", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b4de07c4b894618b95fc8df7917ca03.json"}}, {"family": "Elfakir", "given": "Anissa", "initials": "A"}, {"family": "Gordon", "given": "Anthony C", "initials": "AC", "orcid": "0000-0002-0419-547X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/85b43173291c4fb8b83df85d5dfb3486.json"}}, {"family": "Hernandez-Cardenas", "given": "Carmen M", "initials": "CM", "orcid": "0000-0002-0311-2978", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0aa3c0ab8d3b4da0a63a8d81a5c7d798.json"}}, {"family": "Hills", "given": "Thomas", "initials": "T", "orcid": "0000-0003-0322-5822", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf854b51c68b4b3fb3edee63faa3dfff.json"}}, {"family": "Hoepelman", "given": "Andy I M", "initials": "AIM"}, {"family": "Huang", "given": "Yi-Wen", "initials": "YW"}, {"family": "Igau", "given": "Bruno", "initials": "B"}, {"family": "Jin", "given": "Ronghua", "initials": "R"}, {"family": "Jurado-Camacho", "given": "Felipe", "initials": "F"}, {"family": "Khan", "given": "Khalid S", "initials": "KS"}, {"family": "Kremsner", "given": "Peter G", "initials": "PG"}, {"family": "Kreuels", "given": "Benno", "initials": "B", "orcid": "0000-0003-2315-8954", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/752c98a06cbb43f9b5b8bf63127dd654.json"}}, {"family": "Kuo", "given": "Cheng-Yu", "initials": "CY"}, {"family": "Le", "given": "Thuy", "initials": "T", "orcid": "0000-0002-3393-6580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2380b23c0d1f423aa831d72279980706.json"}}, {"family": "Lin", "given": "Yi-Chun", "initials": "YC"}, {"family": "Lin", "given": "Wu-Pu", "initials": "WP", "orcid": "0000-0002-4206-7882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86d19e5169de4a139c6508eb7bd1e085.json"}}, {"family": "Lin", "given": "Tse-Hung", "initials": "TH"}, {"family": "Lyngbakken", "given": "Magnus Nakrem", "initials": "MN", "orcid": "0000-0002-5994-9304", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70c443e4d3674615bf090ed3b0d39e98.json"}}, {"family": "McArthur", "given": "Colin", "initials": "C"}, {"family": "McVerry", "given": "Bryan J", "initials": "BJ", "orcid": "0000-0002-1175-4874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/941d8c555b224fb18d897e9201d42f35.json"}}, {"family": "Meza-Meneses", "given": "Patricia", "initials": "P", "orcid": "0000-0002-3931-3114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be8220f4a58244838e2252f67c3ea28b.json"}}, {"family": "Monteiro", "given": "Wuelton M", "initials": "WM"}, {"family": "Morpeth", "given": "Susan C", "initials": "SC"}, {"family": "Mourad", "given": "Ahmad", "initials": "A", "orcid": "0000-0002-3149-597X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3323fc32cf4e44b2b677b838954f86aa.json"}}, {"family": "Mulligan", "given": "Mark J", "initials": "MJ"}, {"family": "Murthy", "given": "Srinivas", "initials": "S"}, {"family": "Naggie", "given": "Susanna", "initials": "S"}, {"family": "Narayanasamy", "given": "Shanti", "initials": "S", "orcid": "0000-0002-6667-2868", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53cc5ca9db8d49678370dbaad3d91ac0.json"}}, {"family": "Nichol", "given": "Alistair", "initials": "A"}, {"family": "Novack", "given": "Lewis A", "initials": "LA"}, {"family": "O'Brien", "given": "Sean M", "initials": "SM"}, {"family": "Okeke", "given": "Nwora Lance", "initials": "NL"}, {"family": "Perez", "given": "L\u00e9na", "initials": "L"}, {"family": "Perez-Padilla", "given": "Rogelio", "initials": "R"}, {"family": "Perrin", "given": "Laurent", "initials": "L", "orcid": "0000-0002-1916-6639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bdac388f14a404aa6a02e69083181fb.json"}}, {"family": "Remigio-Luna", "given": "Arantxa", "initials": "A"}, {"family": "Rivera-Martinez", "given": "Norma E", "initials": "NE", "orcid": "0000-0002-6716-1234", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0214c04c5d94f0082f9068398ab6e37.json"}}, {"family": "Rockhold", "given": "Frank W", "initials": "FW", "orcid": "0000-0003-3732-4765", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/409f57f9cdcd46f7bac6c309f50f6673.json"}}, {"family": "Rodriguez-Llamazares", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-7864-8953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76eb08936ea3405eb020251713f28c3d.json"}}, {"family": "Rolfe", "given": "Robert", "initials": "R"}, {"family": "Rosa", "given": "Rossana", "initials": "R"}, {"family": "R\u00f8sj\u00f8", "given": "Helge", "initials": "H"}, {"family": "Sampaio", "given": "Vanderson S", "initials": "VS", "orcid": "0000-0001-7307-8851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/934ee588c764416998481a7dbe4aad3e.json"}}, {"family": "Seto", "given": "Todd B", "initials": "TB"}, {"family": "Shahzad", "given": "Muhammad", "initials": "M"}, {"family": "Soliman", "given": "Shaimaa", "initials": "S"}, {"family": "Stout", "given": "Jason E", "initials": "JE", "orcid": "0000-0002-6698-8176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45ca2262503a439db34471f94f65aa11.json"}}, {"family": "Thirion-Romero", "given": "Ireri", "initials": "I"}, {"family": "Troxel", "given": "Andrea B", "initials": "AB"}, {"family": "Tseng", "given": "Ting-Yu", "initials": "TY"}, {"family": "Turner", "given": "Nicholas A", "initials": "NA", "orcid": "0000-0003-0650-4894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7aa17d22034b4cc4aca4c38f6323c099.json"}}, {"family": "Ulrich", "given": "Robert J", "initials": "RJ", "orcid": "0000-0002-3217-5062", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d560647d4cd74ecaa958445933fef02d.json"}}, {"family": "Walsh", "given": "Stephen R", "initials": "SR", "orcid": "0000-0002-0817-9370", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5569d26075364c7294b1d49d084d27bf.json"}}, {"family": "Webb", "given": "Steve A", "initials": "SA"}, {"family": "Weehuizen", "given": "Jesper M", "initials": "JM"}, {"family": "Velinova", "given": "Maria", "initials": "M"}, {"family": "Wong", "given": "Hon-Lai", "initials": "HL"}, {"family": "Wrenn", "given": "Rebekah", "initials": "R"}, {"family": "Zampieri", "given": "Fernando G", "initials": "FG", "orcid": "0000-0001-9315-6386", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6d3264c064a4675bdbde7937711265c.json"}}, {"family": "Zhong", "given": "Wu", "initials": "W", "orcid": "0000-0002-0536-620X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8058cd239379403195b1cd7d9b5ca689.json"}}, {"family": "Moher", "given": "David", "initials": "D", "orcid": "0000-0003-2434-4206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/765e99136e2943c7a7f4ce4ed5848ff9.json"}}, {"family": "Goodman", "given": "Steven N", "initials": "SN"}, {"family": "Ioannidis", "given": "John P A", "initials": "JPA", "orcid": "0000-0003-3118-6859", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9844ea41bc554157a721820d7986a442.json"}}, {"family": "Hemkens", "given": "Lars G", "initials": "LG", "orcid": "0000-0002-3444-1432", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b2562d656a74e7d91427b55ca667784.json"}}], "type": "journal article", "published": "2021-04-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "2349"}, "abstract": "Substantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or early discontinuation. We aim to estimate the effects of hydroxychloroquine and chloroquine on survival in COVID-19 from all currently available RCT evidence, published and unpublished. We present a rapid meta-analysis of ongoing, completed, or discontinued RCTs on hydroxychloroquine or chloroquine treatment for any COVID-19 patients (protocol: https://osf.io/QESV4/ ). We systematically identified unpublished RCTs (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, Cochrane COVID-registry up to June 11, 2020), and published RCTs (PubMed, medRxiv and bioRxiv up to October 16, 2020). All-cause mortality has been extracted (publications/preprints) or requested from investigators and combined in random-effects meta-analyses, calculating odds ratios (ORs) with 95% confidence intervals (CIs), separately for hydroxychloroquine and chloroquine. Prespecified subgroup analyses include patient setting, diagnostic confirmation, control type, and publication status. Sixty-three trials were potentially eligible. We included 14 unpublished trials (1308 patients) and 14 publications/preprints (9011 patients). Results for hydroxychloroquine are dominated by RECOVERY and WHO SOLIDARITY, two highly pragmatic trials, which employed relatively high doses and included 4716 and 1853 patients, respectively (67% of the total sample size). The combined OR on all-cause mortality for hydroxychloroquine is 1.11 (95% CI: 1.02, 1.20; I\u00b2 = 0%; 26 trials; 10,012 patients) and for chloroquine 1.77 (95%CI: 0.15, 21.13, I\u00b2 = 0%; 4 trials; 307 patients). We identified no subgroup effects. We found that treatment with hydroxychloroquine is associated with increased mortality in COVID-19 patients, and there is no benefit of chloroquine. Findings have unclear generalizability to outpatients, children, pregnant women, and people with comorbidities.", "doi": "10.1038/s41467-021-22446-z", "pmid": "33859192", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC8050319"}, {"db": "pii", "key": "10.1038/s41467-021-22446-z"}], "notes": [], "created": "2021-04-19T09:55:46.003Z", "modified": "2023-06-19T15:39:29.947Z"}, {"entity": "publication", "iuid": "6962a2e2313a498f92cb46da8b7054c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6962a2e2313a498f92cb46da8b7054c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6962a2e2313a498f92cb46da8b7054c9"}}, "title": "Impaired diffusing capacity for carbon monoxide is common in critically ill Covid-19 patients at four months post-discharge.", "authors": [{"family": "Ekbom", "given": "E", "initials": "E"}, {"family": "Frithiof", "given": "R", "initials": "R"}, {"family": "Emilsson", "given": "\u00d6", "initials": "\u00d6"}, {"family": "Larson", "given": "IM", "initials": "I"}, {"family": "Lipcsey", "given": "M", "initials": "M"}, {"family": "Rubertsson", "given": "S", "initials": "S"}, {"family": "Wallin", "given": "E", "initials": "E"}, {"family": "Janson", "given": "C", "initials": "C"}, {"family": "Hultstr\u00f6m", "given": ", M", "initials": ",M"}, {"family": "Malinovschi", "given": ", A", "initials": ",A"}], "type": "journal article", "published": "2021-04-15", "journal": {"title": "Respir Med", "issn": "1532-3064", "issn-l": "0954-6111", "volume": "182", "issue": null, "pages": "106394"}, "abstract": "There is limited knowledge about the long-term effects on pulmonary function of COVID-19 in patients that required intensive care treatment. Spirometry and diffusing capacity for carbon monoxide (DLCO) were measured in 60 subjects at 3-6 months post discharge. Impaired lung function was found in 52% of the subjects, with reduced DLCO as the main finding. The risk increased with age above 60 years, need for mechanical ventilation and longer ICU stay as well as lower levels of C-reactive protein at admission. This suggests the need of follow-up with pulmonary function testing in intensive-care treated patients.", "doi": "10.1016/j.rmed.2021.106394", "pmid": "33901787", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pii", "key": "S0954-6111(21)00100-1"}], "notes": [], "created": "2021-04-29T10:24:46.257Z", "modified": "2021-06-11T14:13:00.138Z"}, {"entity": "publication", "iuid": "a78e8cfff07a42a39fd12fc31fd02007", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a78e8cfff07a42a39fd12fc31fd02007.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a78e8cfff07a42a39fd12fc31fd02007"}}, "title": "Impacts of COVID-19 on sick leave", "authors": [{"family": "Skyrud", "given": "Katrine", "initials": "K"}, {"family": "Telle", "given": "Kjetil", "initials": "K"}, {"family": "Hern\u00e6s", "given": "Kjersti", "initials": "K"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "posted-content", "published": "2021-04-15", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.09.21255215", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-14T06:41:17.696Z", "modified": "2021-06-18T09:28:15.257Z"}, {"entity": "publication", "iuid": "2813f0500ac641f09c8b641b69e12be7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2813f0500ac641f09c8b641b69e12be7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2813f0500ac641f09c8b641b69e12be7"}}, "title": "Immune Profile in Patients With COVID-19: Lymphocytes Exhaustion Markers in Relationship to Clinical Outcome.", "authors": [{"family": "Bobcakova", "given": "Anna", "initials": "A"}, {"family": "Petriskova", "given": "Jela", "initials": "J"}, {"family": "Vysehradsky", "given": "Robert", "initials": "R"}, {"family": "Kocan", "given": "Ivan", "initials": "I"}, {"family": "Kapustova", "given": "Lenka", "initials": "L"}, {"family": "Barnova", "given": "Martina", "initials": "M"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}, {"family": "Jesenak", "given": "Milos", "initials": "M"}], "type": "journal article", "published": "2021-04-15", "journal": {"title": "Front Cell Infect Microbiol", "issn": "2235-2988", "volume": "11", "issue": null, "pages": "646688", "issn-l": null}, "abstract": "The velocity of the COVID-19 pandemic spread and the variable severity of the disease course has forced scientists to search for potential predictors of the disease outcome. We examined various immune parameters including the markers of immune cells exhaustion and activation in 21 patients with COVID-19 disease hospitalised in our hospital during the first wave of the COVID-19 pandemic in Slovakia. The results showed significant progressive lymphopenia and depletion of lymphocyte subsets (CD3 +, CD4+, CD8+ and CD19+) in correlation to the disease severity. Clinical recovery was associated with significant increase in CD3+ and CD3+CD4+ T-cells. Most of our patients had eosinopenia on admission, although no significant differences were seen among groups with different disease severity. Non-survivors, when compared to survivors, had significantly increased expression of PD-1 on CD4+ and CD8+ cells, but no significant difference in Tim-3 expression was observed, what suggests possible reversibility of immune paralysis in the most severe group of patients. During recovery, the expression of Tim-3 on both CD3+CD4+ and CD3+CD8+ cells significantly decreased. Moreover, patients with fatal outcome had significantly higher proportion of CD38+CD8+ cells and lower proportion of CD38+HLA-DR+CD8+ cells on admission. Clinical recovery was associated with significant decrease of proportion of CD38+CD8+ cells. The highest AUC values within univariate and multivariate logistic regression were achieved for expression of CD38 on CD8+ cells and expression of PD1 on CD4+ cells alone or combined, what suggests, that these parameters could be used as potential biomarkers of poor outcome. The assessment of immune markers could help in predicting outcome and disease severity in COVID-19 patients. Our observations suggest, that apart from the degree of depletion of total lymphocytes and lymphocytes subsets, increased expression of CD38 on CD3+CD8+ cells alone or combined with increased expression of PD-1 on CD3+CD4+ cells, should be regarded as a risk factor of an unfavourable outcome in COVID-19 patients. Increased expression of PD-1 in the absence of an increased expression of Tim-3 on CD3+CD4+ and CD3+CD8+ cells suggests potential reversibility of ongoing immune paralysis in patients with the most severe course of COVID-19.", "doi": "10.3389/fcimb.2021.646688", "pmid": "33937096", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8082075"}], "notes": [], "created": "2021-05-04T15:59:00.820Z", "modified": "2021-05-04T15:59:29.077Z"}, {"entity": "publication", "iuid": "59f5bb4de6904a3c86e0194414dec772", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/59f5bb4de6904a3c86e0194414dec772.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/59f5bb4de6904a3c86e0194414dec772"}}, "title": "Appropriateness for SARS-CoV-2 vaccination for otolaryngologist and head and neck surgeons in case of pregnancy, breastfeeding, or childbearing potential: Yo-IFOS and CEORL-HNS joint clinical consensus statement.", "authors": [{"family": "Saibene", "given": "Alberto Maria", "initials": "AM"}, {"family": "Allevi", "given": "Fabiana", "initials": "F"}, {"family": "Ayad", "given": "Tareck", "initials": "T"}, {"family": "Baudoin", "given": "Tomislav", "initials": "T"}, {"family": "Bernal-Sprekelsen", "given": "Manuel", "initials": "M"}, {"family": "Briganti", "given": "Giovanni", "initials": "G"}, {"family": "Carrie", "given": "Sean", "initials": "S"}, {"family": "Cay\u00e9-Thomasen", "given": "Per", "initials": "P"}, {"family": "Dahman Saidi", "given": "Sara", "initials": "S"}, {"family": "Dauby", "given": "Nicolas", "initials": "N"}, {"family": "Fenton", "given": "John", "initials": "J"}, {"family": "Golusi\u0144ski", "given": "Wojciech", "initials": "W"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Leclerc", "given": "Andr\u00e9e-Anne", "initials": "A"}, {"family": "Longtin", "given": "Yves", "initials": "Y"}, {"family": "Mannelli", "given": "Giuditta", "initials": "G"}, {"family": "Mayo-Y\u00e1\u00f1ez", "given": "Miguel", "initials": "M"}, {"family": "Me\u00e7o", "given": "Cem", "initials": "C"}, {"family": "Metwaly", "given": "Osama", "initials": "O"}, {"family": "Mouawad", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Niemczyk", "given": "Kazimierz", "initials": "K"}, {"family": "Pedersen", "given": "Ulrik", "initials": "U"}, {"family": "Piersiala", "given": "Krzysztof", "initials": "K"}, {"family": "Plzak", "given": "Jan", "initials": "J"}, {"family": "Remacle", "given": "Marc", "initials": "M"}, {"family": "Rommel", "given": "Nathalie", "initials": "N"}, {"family": "Saleh", "given": "Hesham", "initials": "H"}, {"family": "Szpecht", "given": "Dawid", "initials": "D"}, {"family": "Tedla", "given": "Miroslav", "initials": "M"}, {"family": "Tincati", "given": "Camilla", "initials": "C"}, {"family": "Tucciarone", "given": "Manuel", "initials": "M"}, {"family": "Zelenik", "given": "Karol", "initials": "K"}, {"family": "Lechien", "given": "Jerome R", "initials": "JR"}], "type": "journal article", "published": "2021-04-15", "journal": {"title": "Eur Arch Otorhinolaryngol", "issn": "1434-4726", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "SARS-CoV-2 vaccines are a key step in fighting the pandemic. Nevertheless, their rapid development did not allow for testing among specific population subgroups such as pregnant and breastfeeding women, or elaborating specific guidelines for healthcare personnel working in high infection risk specialties, such as otolaryngology (ORL). This clinical consensus statement (CCS) aims to offer guidance for SARS-CoV-2 vaccination to this high-risk population based on the best evidence available.\r\n\r\nA multidisciplinary international panel of 33 specialists judged statements through a two-round modified Delphi method survey. Statements were designed to encompass the following topics: risk of SARS-Cov-2 infection and use of protective equipment in ORL; SARS-Cov-2 infection and vaccines and respective risks for the mother/child dyad; and counseling for SARS-CoV-2 vaccination in pregnant, breastfeeding, or fertile healthcare workers (PBFHW). All ORL PBFHW were considered as the target audience.\r\n\r\nOf the 13 statements, 7 reached consensus or strong consensus, 2 reached no consensus, and 2 reached near-consensus. According to the statements with strong consensus otorhinolaryngologists-head and neck surgeons who are pregnant, breastfeeding, or with childbearing potential should have the opportunity to receive SARS-Cov-2 vaccination. Moreover, personal protective equipment (PPE) should still be used even after the vaccination.\r\n\r\nUntil prospective evaluations on these topics are available, ORL-HNS must be considered a high infection risk specialty. While the use of PPE remains pivotal, ORL PBFHW should be allowed access to SARS-CoV-2 vaccination provided they receive up-to-date information.", "doi": "10.1007/s00405-021-06794-6", "pmid": "33855628", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00405-021-06794-6"}, {"db": "pmc", "key": "PMC8046580"}], "notes": [], "created": "2021-04-19T09:53:24.711Z", "modified": "2021-04-19T09:53:40.064Z"}, {"entity": "publication", "iuid": "ad1e20fc179f437b8ca521f323d4b8ea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ad1e20fc179f437b8ca521f323d4b8ea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ad1e20fc179f437b8ca521f323d4b8ea"}}, "title": "A distinct metabolic profile associated with a fatal outcome in COVID-19 patients during early epidemic in Italy", "authors": [{"family": "Saccon", "given": "Elisa", "initials": "E"}, {"family": "Bandera", "given": "Alessandra", "initials": "A"}, {"family": "Scium\u00e8", "given": "Mariarita", "initials": "M"}, {"family": "Mikeloff", "given": "Flora", "initials": "F"}, {"family": "Lashari", "given": "Abid Ali", "initials": "AA"}, {"family": "Aliberti", "given": "Stefano", "initials": "S"}, {"family": "Sachs", "given": "Michael", "initials": "M"}, {"family": "Billi", "given": "Filippo", "initials": "F"}, {"family": "Blasi", "given": "Francesco", "initials": "F"}, {"family": "Gabriel", "given": "Erin", "initials": "E"}, {"family": "Costantino", "given": "Giorgio", "initials": "G"}, {"family": "De Roberto", "given": "Pasquale", "initials": "P"}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Gori", "given": "Andrea", "initials": "A"}, {"family": "Peyvandi", "given": "Flora", "initials": "F"}, {"family": "Scudeller", "given": "Luigia", "initials": "L"}, {"family": "Lorson", "given": "Christian L", "initials": "CL"}, {"family": "Valenti", "given": "Luca", "initials": "L"}, {"family": "Singh", "given": "Kamal", "initials": "K"}, {"family": "Baldini", "given": "Luca", "initials": "L"}, {"family": "Fracchiolla", "given": "Nicola Stefano", "initials": "NS"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "posted-content", "published": "2021-04-15", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.13.21255117", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-29T16:43:34.352Z", "modified": "2021-06-04T14:21:33.699Z"}, {"entity": "publication", "iuid": "3f9371406eef47b4b4cb3d96d22bf226", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f9371406eef47b4b4cb3d96d22bf226.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f9371406eef47b4b4cb3d96d22bf226"}}, "title": "Coronavirus Disease 19 from the Perspective of Ageing with Focus on Nutritional Status and Nutrition Management-A Narrative Review.", "authors": [{"family": "Rothenberg", "given": "Elisabet", "initials": "E"}], "type": "journal article", "published": "2021-04-14", "journal": {"title": "Nutrients", "issn": "2072-6643", "volume": "13", "issue": "4", "issn-l": null}, "abstract": "The novel severe acute respiratory syndrome coronavirus (COVID-19) has hit older adults harder due to a combination of age-related immunological and metabolic alterations. The aim of this review was to analyze the COVID-19 literature with respect to nutritional status and nutrition management in older adults. No studies only on people aged 65+ years were found, and documentation on those 80+ was rare. Age was found to be strongly associated with worse outcomes, and with poor nutritional status. Prevalence of malnutrition was high among severely and critically ill patients. The studies found a need for nutrition screening and management, and for nutrition support as part of follow-up after a hospital stay. Most tested screening tools showed high sensitivity in identifying nutritional risk, but none were recognized as best for screening older adults with COVID-19. For diagnosing malnutrition, the Global Leadership Initiative on Malnutrition (GLIM) criteria are recommended but were not used in the studies found. Documentation of olfactory and gustatory dysfunction in relation to nutritional status is missing in older adults. Other COVID-19-associated factors with a possible impact on nutritional status are poor appetite and gastrointestinal symptoms. Vitamin D is the nutrient that has attracted the most interest. However, evidence for supplementation of COVID-19 patients is still limited and inconclusive.", "doi": "10.3390/nu13041294", "pmid": "33919840", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "nu13041294"}, {"db": "pmc", "key": "PMC8070771"}], "notes": [], "created": "2021-05-04T16:25:12.442Z", "modified": "2021-05-04T16:25:46.758Z"}, {"entity": "publication", "iuid": "f754dc7c44e04bf2ae96d4f2bf59913c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f754dc7c44e04bf2ae96d4f2bf59913c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f754dc7c44e04bf2ae96d4f2bf59913c"}}, "title": "Visual scoring of chest CT at hospital admission predicts hospitalization time and intensive care admission in Covid-19.", "authors": [{"family": "Ahlstrand", "given": "Erik", "initials": "E"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "Cajander", "given": "Per", "initials": "P"}, {"family": "Ingberg", "given": "Edvin", "initials": "E"}, {"family": "L\u00f6f", "given": "Erika", "initials": "E"}, {"family": "Wegener", "given": "Matthias", "initials": "M"}, {"family": "Lid\u00e9n", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2021-04-13", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": null, "issue": null, "pages": "1-11"}, "abstract": "Chest CT is prognostic in Covid-19 but there is a lack of consensus on how to report the CT findings. A chest CT scoring system, \u00d6CoS, was implemented in clinical routine on 1 April 2020, in \u00d6rebro Region, Sweden. The \u00d6CoS-severity score measures the extent of lung involvement. The objective of the study was to evaluate the \u00d6CoS scores as predictors of the clinical course of Covid-19.\r\n\r\nPopulation based study including data from all hospitalized patients with Covid-19 in \u00d6rebro Region during March to July 2020. We evaluated the correlations between CT scores at the time of admission to hospital and intensive care in relation to hospital and intensive care length of stay (LoS), intensive care admission and death. C-reactive protein and lymphocyte count were included as covariates in multivariate regression analyses.\r\n\r\nIn 381 included patients, the \u00d6CoS-severity score at admission closely correlated to hospital length of stay, and intensive care admission or death. At admission to intensive care, the \u00d6CoS-severity score correlated with intensive care length of stay. The \u00d6CoS-severity score was superior to basic inflammatory biomarkers in predicting clinical outcomes.\r\n\r\nChest CT visual scoring at admission to hospital predicted the clinical course of Covid-19 pneumonia.", "doi": "10.1080/23744235.2021.1910727", "pmid": "33848219", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-14T14:27:47.477Z", "modified": "2021-04-14T14:27:58.253Z"}, {"entity": "publication", "iuid": "089b4032333d45b9ae32c98f22312369", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/089b4032333d45b9ae32c98f22312369.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/089b4032333d45b9ae32c98f22312369"}}, "title": "Suicide trends in the early months of the COVID-19 pandemic: an interrupted time-series analysis of preliminary data from 21 countries.", "authors": [{"family": "Pirkis", "given": "Jane", "initials": "J"}, {"family": "John", "given": "Ann", "initials": "A"}, {"family": "Shin", "given": "Sangsoo", "initials": "S"}, {"family": "DelPozo-Banos", "given": "Marcos", "initials": "M"}, {"family": "Arya", "given": "Vikas", "initials": "V"}, {"family": "Analuisa-Aguilar", "given": "Pablo", "initials": "P"}, {"family": "Appleby", "given": "Louis", "initials": "L"}, {"family": "Arensman", "given": "Ella", "initials": "E"}, {"family": "Bantjes", "given": "Jason", "initials": "J"}, {"family": "Baran", "given": "Anna", "initials": "A"}, {"family": "Bertolote", "given": "Jose M", "initials": "JM"}, {"family": "Borges", "given": "Guilherme", "initials": "G"}, {"family": "Bre\u010di\u0107", "given": "Petrana", "initials": "P"}, {"family": "Caine", "given": "Eric", "initials": "E"}, {"family": "Castelpietra", "given": "Giulio", "initials": "G"}, {"family": "Chang", "given": "Shu-Sen", "initials": "S"}, {"family": "Colchester", "given": "David", "initials": "D"}, {"family": "Crompton", "given": "David", "initials": "D"}, {"family": "Curkovic", "given": "Marko", "initials": "M"}, {"family": "Deisenhammer", "given": "Eberhard A", "initials": "EA"}, {"family": "Du", "given": "Chengan", "initials": "C"}, {"family": "Dwyer", "given": "Jeremy", "initials": "J"}, {"family": "Erlangsen", "given": "Annette", "initials": "A"}, {"family": "Faust", "given": "Jeremy S", "initials": "JS"}, {"family": "Fortune", "given": "Sarah", "initials": "S"}, {"family": "Garrett", "given": "Andrew", "initials": "A"}, {"family": "George", "given": "Devin", "initials": "D"}, {"family": "Gerstner", "given": "Rebekka", "initials": "R"}, {"family": "Gilissen", "given": "Renske", "initials": "R"}, {"family": "Gould", "given": "Madelyn", "initials": "M"}, {"family": "Hawton", "given": "Keith", "initials": "K"}, {"family": "Kanter", "given": "Joseph", "initials": "J"}, {"family": "Kapur", "given": "Navneet", "initials": "N"}, {"family": "Khan", "given": "Murad", "initials": "M"}, {"family": "Kirtley", "given": "Olivia J", "initials": "OJ"}, {"family": "Knipe", "given": "Duleeka", "initials": "D"}, {"family": "Kolves", "given": "Kairi", "initials": "K"}, {"family": "Leske", "given": "Stuart", "initials": "S"}, {"family": "Marahatta", "given": "Kedar", "initials": "K"}, {"family": "Mittendorfer-Rutz", "given": "Ellenor", "initials": "E"}, {"family": "Neznanov", "given": "Nikolay", "initials": "N"}, {"family": "Niederkrotenthaler", "given": "Thomas", "initials": "T"}, {"family": "Nielsen", "given": "Emma", "initials": "E"}, {"family": "Nordentoft", "given": "Merete", "initials": "M"}, {"family": "Oberlerchner", "given": "Herwig", "initials": "H"}, {"family": "O'Connor", "given": "Rory C", "initials": "RC"}, {"family": "Pearson", "given": "Melissa", "initials": "M"}, {"family": "Phillips", "given": "Michael R", "initials": "MR"}, {"family": "Platt", "given": "Steve", "initials": "S"}, {"family": "Plener", "given": "Paul L", "initials": "PL"}, {"family": "Psota", "given": "Georg", "initials": "G"}, {"family": "Qin", "given": "Ping", "initials": "P"}, {"family": "Radeloff", "given": "Daniel", "initials": "D"}, {"family": "Rados", "given": "Christa", "initials": "C"}, {"family": "Reif", "given": "Andreas", "initials": "A"}, {"family": "Reif-Leonhard", "given": "Christine", "initials": "C"}, {"family": "Rozanov", "given": "Vsevolod", "initials": "V"}, {"family": "Schlang", "given": "Christiane", "initials": "C"}, {"family": "Schneider", "given": "Barbara", "initials": "B"}, {"family": "Semenova", "given": "Natalia", "initials": "N"}, {"family": "Sinyor", "given": "Mark", "initials": "M"}, {"family": "Townsend", "given": "Ellen", "initials": "E"}, {"family": "Ueda", "given": "Michiko", "initials": "M"}, {"family": "Vijayakumar", "given": "Lakshmi", "initials": "L"}, {"family": "Webb", "given": "Roger T", "initials": "RT"}, {"family": "Weerasinghe", "given": "Manjula", "initials": "M"}, {"family": "Zalsman", "given": "Gil", "initials": "G"}, {"family": "Gunnell", "given": "David", "initials": "D"}, {"family": "Spittal", "given": "Matthew J", "initials": "MJ"}], "type": "journal article", "published": "2021-04-13", "journal": {"title": "Lancet Psychiatry", "issn": "2215-0374", "issn-l": "2215-0366", "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic is having profound mental health consequences for many people. Concerns have been expressed that, at their most extreme, these consequences could manifest as increased suicide rates. We aimed to assess the early effect of the COVID-19 pandemic on suicide rates around the world.\r\n\r\nWe sourced real-time suicide data from countries or areas within countries through a systematic internet search and recourse to our networks and the published literature. Between Sept 1 and Nov 1, 2020, we searched the official websites of these countries' ministries of health, police agencies, and government-run statistics agencies or equivalents, using the translated search terms \"suicide\" and \"cause of death\", before broadening the search in an attempt to identify data through other public sources. Data were included from a given country or area if they came from an official government source and were available at a monthly level from at least Jan 1, 2019, to July 31, 2020. Our internet searches were restricted to countries with more than 3 million residents for pragmatic reasons, but we relaxed this rule for countries identified through the literature and our networks. Areas within countries could also be included with populations of less than 3 million. We used an interrupted time-series analysis to model the trend in monthly suicides before COVID-19 (from at least Jan 1, 2019, to March 31, 2020) in each country or area within a country, comparing the expected number of suicides derived from the model with the observed number of suicides in the early months of the pandemic (from April 1 to July 31, 2020, in the primary analysis).\r\n\r\nWe sourced data from 21 countries (16 high-income and five upper-middle-income countries), including whole-country data in ten countries and data for various areas in 11 countries). Rate ratios (RRs) and 95% CIs based on the observed versus expected numbers of suicides showed no evidence of a significant increase in risk of suicide since the pandemic began in any country or area. There was statistical evidence of a decrease in suicide compared with the expected number in 12 countries or areas: New South Wales, Australia (RR 0\u00b781 [95% CI 0\u00b772-0\u00b791]); Alberta, Canada (0\u00b780 [0\u00b768-0\u00b793]); British Columbia, Canada (0\u00b776 [0\u00b766-0\u00b787]); Chile (0\u00b785 [0\u00b778-0\u00b794]); Leipzig, Germany (0\u00b749 [0\u00b732-0\u00b774]); Japan (0\u00b794 [0\u00b791-0\u00b796]); New Zealand (0\u00b779 [0\u00b768-0\u00b791]); South Korea (0\u00b794 [0\u00b792-0\u00b797]); California, USA (0\u00b790 [0\u00b785-0\u00b795]); Illinois (Cook County), USA (0\u00b779 [0\u00b767-0\u00b793]); Texas (four counties), USA (0\u00b782 [0\u00b768-0\u00b798]); and Ecuador (0\u00b774 [0\u00b767-0\u00b782]).\r\n\r\nThis is the first study to examine suicides occurring in the context of the COVID-19 pandemic in multiple countries. In high-income and upper-middle-income countries, suicide numbers have remained largely unchanged or declined in the early months of the pandemic compared with the expected levels based on the pre-pandemic period. We need to remain vigilant and be poised to respond if the situation changes as the longer-term mental health and economic effects of the pandemic unfold.\r\n\r\nNone.", "doi": "10.1016/S2215-0366(21)00091-2", "pmid": "33862016", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2215-0366(21)00091-2"}], "notes": [], "created": "2021-04-19T10:38:03.711Z", "modified": "2021-04-19T10:38:33.043Z"}, {"entity": "publication", "iuid": "84cac197afb5412a821b404f0f43a2ce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84cac197afb5412a821b404f0f43a2ce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84cac197afb5412a821b404f0f43a2ce"}}, "title": "Structure, Dynamics, Receptor Binding, and Antibody Binding of the Fully Glycosylated Full-Length SARS-CoV-2 Spike Protein in a Viral Membrane.", "authors": [{"family": "Choi", "given": "Yeol Kyo", "initials": "YK", "orcid": "0000-0002-4218-7139", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2885ea927174b0aabe0ab76d5fba484.json"}}, {"family": "Cao", "given": "Yiwei", "initials": "Y", "orcid": "0000-0002-4516-8689", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15efd17a7c1342a3aa46bab1e2b9e241.json"}}, {"family": "Frank", "given": "Martin", "initials": "M", "orcid": "0000-0002-1006-6746", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee6b5d165615455da3cf49fad65598e9.json"}}, {"family": "Woo", "given": "Hyeonuk", "initials": "H", "orcid": "0000-0002-6495-4087", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2dfd6c1c6f34de2b6b768ce70a67ebb.json"}}, {"family": "Park", "given": "Sang-Jun", "initials": "SJ", "orcid": "0000-0002-7307-3724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dede807702c34573bfe7de0b40c48de9.json"}}, {"family": "Yeom", "given": "Min Sun", "initials": "MS", "orcid": "0000-0001-9977-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7ae6fb73cfb47199fd5e4a468aa5554.json"}}, {"family": "Croll", "given": "Tristan I", "initials": "TI", "orcid": "0000-0002-3514-8377", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a6c1536819d496490962f5f89bebc6f.json"}}, {"family": "Seok", "given": "Chaok", "initials": "C", "orcid": "0000-0002-1419-9888", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a93933221aa54cda9547eb7f063c154c.json"}}, {"family": "Im", "given": "Wonpil", "initials": "W", "orcid": "0000-0001-5642-6041", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c6b1fc87fa647459c5a112e9fa6b8ce.json"}}], "type": "journal article", "published": "2021-04-13", "journal": {"title": "J Chem Theory Comput", "issn": "1549-9626", "issn-l": null, "volume": "17", "issue": "4", "pages": "2479-2487"}, "abstract": "The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mediates host cell entry by binding to angiotensin-converting enzyme 2 (ACE2) and is considered the major target for drug and vaccine development. We previously built fully glycosylated full-length SARS-CoV-2 S protein models in a viral membrane including both open and closed conformations of the receptor-binding domain (RBD) and different templates for the stalk region. In this work, multiple \u03bcs-long all-atom molecular dynamics simulations were performed to provide deeper insights into the structure and dynamics of S protein and glycan functions. Our simulations reveal that the highly flexible stalk is composed of two independent joints and most probable S protein orientations are competent for ACE2 binding. We identify multiple glycans stabilizing the open and/or closed states of the RBD and demonstrate that the exposure of antibody epitopes can be captured by detailed antibody-glycan clash analysis instead of commonly used accessible surface area analysis that tends to overestimate the impact of glycan shielding and neglect possible detailed interactions between glycan and antibodies. Overall, our observations offer structural and dynamic insights into the SARS-CoV-2 S protein and potentialize for guiding the design of effective antiviral therapeutics.", "doi": "10.1021/acs.jctc.0c01144", "pmid": "33689337", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC8047829"}], "notes": [], "created": "2021-03-12T06:09:38.310Z", "modified": "2023-06-19T14:35:39.264Z"}, {"entity": "publication", "iuid": "cf393d99432444dea582e4df887afe07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cf393d99432444dea582e4df887afe07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cf393d99432444dea582e4df887afe07"}}, "title": "Motivation to Have COVID-19 Vaccination Explained Using an Extended Protection Motivation Theory among University Students in China: The Role of Information Sources.", "authors": [{"family": "Wang", "given": "Peng-Wei", "initials": "P"}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Chen", "given": "I-Hua", "initials": "I"}, {"family": "Yen", "given": "Cheng-Fang", "initials": "C"}, {"family": "Kuo", "given": "Yi-Jie", "initials": "Y"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-04-13", "journal": {"title": "Vaccines", "issn": "2076-393X", "issn-l": null, "volume": "9", "issue": "4", "pages": null}, "abstract": "The aims of the present study were to examine the prediction of the threat and coping appraisal utilizing an extended protection motivation theory (PMT) for the motivation to have COVID-19 vaccination and the influence of various information sources on coping appraisal among university students in China.\r\n\r\nThe sample comprised 3145 students from 43 universities in China who completed an online survey including PMT constructs as well as constructs added to PMT. The PMT constructs comprised motivation to have COVID-19 vaccination, threat appraisal, and coping appraisal. The extended PMT constructs comprised knowledge about mechanisms and information sources of COVID-19 vaccination.\r\n\r\nPerceived severity of COVID-19 was positively associated with motivation to have COVID-19 vaccination. Receiving information concerning COVID-19 vaccination from medical personnel was associated with greater self-efficacy, response efficacy, and knowledge, whereas receiving information concerning COVID-19 vaccination from coworkers/colleagues was associated with less response efficacy and knowledge. Receiving online information concerning COVID-19 vaccination was associated with greater response cost of vaccination efficacy and less knowledge.\r\n\r\nThis study supported the prediction of perceived severity in the PMT for motivation to have COVID-19 vaccination among university students in China. Vaccination information sources have different effects on students' coping appraisal of COVID-19 vaccination.", "doi": "10.3390/vaccines9040380", "pmid": "33924604", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "vaccines9040380"}, {"db": "pmc", "key": "PMC8070343"}], "notes": [], "created": "2021-05-04T16:22:30.374Z", "modified": "2021-07-14T07:14:10.905Z"}, {"entity": "publication", "iuid": "754c69dd322a4156bbbbb6d9131ce4ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/754c69dd322a4156bbbbb6d9131ce4ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/754c69dd322a4156bbbbb6d9131ce4ff"}}, "title": "GRAd-COV2, a gorilla adenovirus based candidate vaccine against COVID-19, is safe and immunogenic in young and older adults", "authors": [{"family": "Lanini", "given": "Simone", "initials": "S"}, {"family": "Capone", "given": "Stefania", "initials": "S"}, {"family": "Antinori", "given": "Andrea", "initials": "A"}, {"family": "Milleri", "given": "Stefano", "initials": "S"}, {"family": "Nicastri", "given": "Emanuele", "initials": "E"}, {"family": "Camerini", "given": "Roberto", "initials": "R"}, {"family": "Agrati", "given": "Chiara", "initials": "C"}, {"family": "Castilletti", "given": "Concetta", "initials": "C"}, {"family": "Mori", "given": "Federica", "initials": "F"}, {"family": "Sacchi", "given": "Alessandra", "initials": "A"}, {"family": "Matusali", "given": "Giulia", "initials": "G"}, {"family": "Gagliardini", "given": "Roberta", "initials": "R"}, {"family": "Ammendola", "given": "Virginia", "initials": "V"}, {"family": "Cimini", "given": "Eleonora", "initials": "E"}, {"family": "Grazioli", "given": "Fabiana", "initials": "F"}, {"family": "Scorzolini", "given": "Laura", "initials": "L"}, {"family": "Napolitano", "given": "Federico", "initials": "F"}, {"family": "Piazzi", "given": "Maria Maddalena", "initials": "MM"}, {"family": "Soriani", "given": "Marco", "initials": "M"}, {"family": "De Luca", "given": "Aldo", "initials": "A"}, {"family": "Battella", "given": "Simone", "initials": "S"}, {"family": "Sommella", "given": "Andrea", "initials": "A"}, {"family": "Contino", "given": "Alessandra M", "initials": "AM"}, {"family": "Barra", "given": "Federica", "initials": "F"}, {"family": "Gentile", "given": "Michela", "initials": "M"}, {"family": "Raggioli", "given": "Angelo", "initials": "A"}, {"family": "Shi", "given": "Yufang", "initials": "Y"}, {"family": "Girardi", "given": "Enrico", "initials": "E"}, {"family": "Maeurer", "given": "Markus", "initials": "M"}, {"family": "Capobianchi", "given": "Maria R", "initials": "MR"}, {"family": "Vaia", "given": "Francesco", "initials": "F"}, {"family": "Piacentini", "given": "Mauro", "initials": "M"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}, {"family": "Vitelli", "given": "Alessandra", "initials": "A"}, {"family": "Colloca", "given": "Stefano", "initials": "S"}, {"family": "Folgori", "given": "Antonella", "initials": "A"}, {"family": "Ippolito", "given": "Giuseppe", "initials": "G"}], "type": "posted-content", "published": "2021-04-13", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.10.21255202", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT04528641", "description": "Cinical trials of GRAd-COV2, a vaccine candidate based on an adenoviral vector derived from a group C Gorilla adenovirus"}], "notes": [], "created": "2021-05-29T16:44:59.400Z", "modified": "2021-11-18T09:44:28.193Z"}, {"entity": "publication", "iuid": "95f9816c0e174280b914ea2b935abbc7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95f9816c0e174280b914ea2b935abbc7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95f9816c0e174280b914ea2b935abbc7"}}, "title": "Does International Travel Frequency Affect COVID-19 Biosecurity Behavior in the United States?", "authors": [{"family": "Kim", "given": "Myung Ja", "initials": "MJ"}, {"family": "Hall", "given": "C Michael", "initials": "CM"}, {"family": "Bonn", "given": "Mark", "initials": "M"}], "type": "journal article", "published": "2021-04-13", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "8", "issn-l": null}, "abstract": "High-quality biosecurity practices are critical to restarting international tourism. Effective market segmentation improves the communication and efficacy of health advice. Travel frequency is an important basis for health-related consumer segmentation, as it is closely related to risk of greater exposure to infectious diseases. Theoretically grounded studies of tourist biosecurity behavior and travel frequency have largely been neglected, although insights into practices and attitudes are especially relevant for coronavirus disease of 2019 (COVID-19 (coronavirus disease of 2019) health responses. Therefore, this research constructed and tested a conceptual model applying Value-Attitude-Behavior theory to US travelers to see whether the frequency of international travel affected tourist COVID-19 related biosecurity behavior. US respondents were drawn from a panel using a quota sampling technique according to the age and gender of American outbound tourists. An online survey was administered in September 2020. The responses (n = 395) of those who traveled internationally within five years were analyzed utilizing partial least squares-structural equation modeling (PLS-SEM) with multi-group analysis. Travel frequency significantly affects biosecurity behavior. High travel frequency (\u22658 trips) has the strongest effect of value on biosecurity attitudes, personal norms, social norms, and biosecurity social norms, leading to biosecurity behaviors. Biosecurity behaviors pertaining to medium travel frequency (4-7 trips) are significantly influenced by personal norms. At low travel frequency (1-3 trips) levels, biosecurity behaviors are stimulated by biosecurity attitudes and social norms, showing the highest predictive power among the three groups. This work provides insights into international travel consumer biosecurity practices and behavior. From a market segmentation perspective, the levels of international travel frequency have various influences on biosecurity values, attitudes, personal norms, social norms, and behaviors. The biosecurity behaviors of low-frequency travelers are found to be the most significant of the three groups, suggesting that individuals who travel less frequently are more likely to practice responsible COVID-19 biosecurity behavior.", "doi": "10.3390/ijerph18084111", "pmid": "33924641", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "ijerph18084111"}, {"db": "pmc", "key": "PMC8068867"}], "notes": [], "created": "2021-05-04T16:22:01.814Z", "modified": "2021-05-04T16:22:01.829Z"}, {"entity": "publication", "iuid": "2a61f282b9484a34bfe7e8b39ea3d2f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2a61f282b9484a34bfe7e8b39ea3d2f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2a61f282b9484a34bfe7e8b39ea3d2f4"}}, "title": "A Deferred-Vaccination Design to Assess Durability of COVID-19 Vaccine Effect After the Placebo Group Is Vaccinated.", "authors": [{"family": "Follmann", "given": "Dean", "initials": "D"}, {"family": "Fintzi", "given": "Jonathan", "initials": "J"}, {"family": "Fay", "given": "Michael P", "initials": "MP"}, {"family": "Janes", "given": "Holly E", "initials": "HE"}, {"family": "Baden", "given": "Lindsey R", "initials": "LR"}, {"family": "El Sahly", "given": "Hana M", "initials": "HM"}, {"family": "Fleming", "given": "Thomas R", "initials": "TR"}, {"family": "Mehrotra", "given": "Devan V", "initials": "DV"}, {"family": "Carpp", "given": "Lindsay N", "initials": "LN"}, {"family": "Juraska", "given": "Michal", "initials": "M"}, {"family": "Benkeser", "given": "David", "initials": "D"}, {"family": "Donnell", "given": "Deborah", "initials": "D"}, {"family": "Fong", "given": "Youyi", "initials": "Y"}, {"family": "Han", "given": "Shu", "initials": "S"}, {"family": "Hirsch", "given": "Ian", "initials": "I"}, {"family": "Huang", "given": "Ying", "initials": "Y"}, {"family": "Huang", "given": "Yunda", "initials": "Y"}, {"family": "Hyrien", "given": "Ollivier", "initials": "O"}, {"family": "Luedtke", "given": "Alex", "initials": "A"}, {"family": "Carone", "given": "Marco", "initials": "M"}, {"family": "Nason", "given": "Martha", "initials": "M"}, {"family": "Vandebosch", "given": "An", "initials": "A"}, {"family": "Zhou", "given": "Honghong", "initials": "H"}, {"family": "Cho", "given": "Iksung", "initials": "I"}, {"family": "Gabriel", "given": "Erin", "initials": "E"}, {"family": "Kublin", "given": "James G", "initials": "JG"}, {"family": "Cohen", "given": "Myron S", "initials": "MS"}, {"family": "Corey", "given": "Lawrence", "initials": "L"}, {"family": "Gilbert", "given": "Peter B", "initials": "PB"}, {"family": "Neuzil", "given": "Kathleen M", "initials": "KM"}], "type": "journal article", "published": "2021-04-13", "journal": {"title": "Ann Intern Med", "issn": "1539-3704", "volume": null, "issue": null, "issn-l": "0003-4819"}, "abstract": "Multiple candidate vaccines to prevent COVID-19 have entered large-scale phase 3 placebo-controlled randomized clinical trials, and several have demonstrated substantial short-term efficacy. At some point after demonstration of substantial efficacy, placebo recipients should be offered the efficacious vaccine from their trial, which will occur before longer-term efficacy and safety are known. The absence of a placebo group could compromise assessment of longer-term vaccine effects. However, by continuing follow-up after vaccination of the placebo group, this study shows that placebo-controlled vaccine efficacy can be mathematically derived by assuming that the benefit of vaccination over time has the same profile for the original vaccine recipients and the original placebo recipients after their vaccination. Although this derivation provides less precise estimates than would be obtained by a standard trial where the placebo group remains unvaccinated, this proposed approach allows estimation of longer-term effect, including durability of vaccine efficacy and whether the vaccine eventually becomes harmful for some. Deferred vaccination, if done open-label, may lead to riskier behavior in the unblinded original vaccine group, confounding estimates of long-term vaccine efficacy. Hence, deferred vaccination via blinded crossover, where the vaccine group receives placebo and vice versa, would be the preferred way to assess vaccine durability and potential delayed harm. Deferred vaccination allows placebo recipients timely access to the vaccine when it would no longer be proper to maintain them on placebo, yet still allows important insights about immunologic and clinical effectiveness over time.", "doi": "10.7326/M20-8149", "pmid": "33844575", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-04-13T10:23:58.229Z", "modified": "2021-06-09T19:27:27.661Z"}, {"entity": "publication", "iuid": "734e379716ef4c33beee223fbf443d36", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/734e379716ef4c33beee223fbf443d36.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/734e379716ef4c33beee223fbf443d36"}}, "title": "UNRAVELING THE THREAD OF UNCONTROLLED IMMUNE RESPONSE IN COVID-19 AND STEMI: AN EMERGING NEED FOR KNOWLEDGE SHARING.", "authors": [{"family": "Rios-Navarro", "given": "Cesar", "initials": "C"}, {"family": "de Dios", "given": "Elena", "initials": "E"}, {"family": "Forteza", "given": "Maria J", "initials": "MJ"}, {"family": "Bodi", "given": "Vicente", "initials": "V"}], "type": "journal article", "published": "2021-04-12", "journal": {"title": "Am J Physiol Heart Circ Physiol", "issn": "1522-1539", "volume": null, "issue": null, "issn-l": null}, "abstract": "The outbreak of severe acute respiratory syndrome coronavirus 2 that first emerged in Wuhan in December 2019 has resulted in the devastating pandemic of coronavirus disease 2019, creating an emerging need for knowledge sharing. Meanwhile, myocardial infarction is and will probably remain the foremost cause of death in the western world throughout the coming decades. Severe deregulation of the immune system can unnecessarily expand the inflammatory response and participate in target and multiple organ failure, in infection but also in critical illness. Indeed, the course and fate of inflammatory cells observed in severe ST-elevation myocardial infarction (neutrophilia, monocytosis and lymphopenia) almost perfectly mirror those recently reported in severe coronavirus disease 2019. A pleiotropic proinflammatory imbalance hampers adaptive immunity in favor of uncontrolled innate immunity and is associated with poorer structural and clinical outcomes. The goal of the present review is to gain greater insight into the cellular and molecular mechanisms underlying this canonical activation and downregulation of the two arms of the immune response in both entities, to better understand their pathophysiology as well as to open the door to innovative therapeutic options. Knowledge sharing can pave the way for therapies with the potential to significantly reduce mortality in both infectious and non-infectious scenarios.", "doi": "10.1152/ajpheart.00934.2020", "pmid": "33844596", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-04-13T10:24:51.869Z", "modified": "2021-04-13T10:25:49.802Z"}, {"entity": "publication", "iuid": "89838a83ae4e439b8431bd07607f3dd6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/89838a83ae4e439b8431bd07607f3dd6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/89838a83ae4e439b8431bd07607f3dd6"}}, "title": "Psychological distress among health professional students during the COVID-19 outbreak - Corrigendum.", "authors": [{"family": "Li", "given": "Yuchen", "initials": "Y"}, {"family": "Wang", "given": "Yue", "initials": "Y"}, {"family": "Jiang", "given": "Jingwen", "initials": "J"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Fall", "given": "Katja", "initials": "K"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Song", "given": "Huan", "initials": "H"}, {"family": "Lu", "given": "Donghao", "initials": "D"}, {"family": "Zhang", "given": "Wei", "initials": "W"}], "type": "journal article", "published": "2021-04-12", "journal": {"title": "Psychol Med", "issn": "1469-8978", "issn-l": "0033-2917", "volume": null, "issue": null, "pages": "1"}, "abstract": null, "doi": "10.1017/S0033291721000714", "pmid": "33843513", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0033291721000714"}], "notes": [], "created": "2021-04-13T10:20:05.981Z", "modified": "2021-07-14T06:59:46.032Z"}, {"entity": "publication", "iuid": "f5e0b6f1a3454be68c578886559abd14", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f5e0b6f1a3454be68c578886559abd14.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f5e0b6f1a3454be68c578886559abd14"}}, "title": "How much is good enough? Insights from myocardial infarction incidence during COVID-19 pandemic.", "authors": [{"family": "Fedorowski", "given": "Artur", "initials": "A"}, {"family": "Erlinge", "given": "David", "initials": "D"}], "type": "editorial", "published": "2021-04-12", "journal": {"title": "Int J Cardiol", "issn": "1874-1754", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/j.ijcard.2021.04.020", "pmid": "33857541", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0167-5273(21)00656-2"}], "notes": [], "created": "2021-04-19T09:54:49.854Z", "modified": "2021-04-29T16:33:48.001Z"}, {"entity": "publication", "iuid": "e3290821941b4153ad8069aac785985e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3290821941b4153ad8069aac785985e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3290821941b4153ad8069aac785985e"}}, "title": "An episode of oral mucositis after the first administration of the ChAdOx1 COVID-19 vaccine.", "authors": [{"family": "Azzi", "given": "Lorenzo", "initials": "L"}, {"family": "Toia", "given": "Marco", "initials": "M"}, {"family": "Stevanello", "given": "Nicole", "initials": "N"}, {"family": "Maggi", "given": "Fabrizio", "initials": "F"}, {"family": "Forlani", "given": "Greta", "initials": "G"}], "type": "letter", "published": "2021-04-12", "journal": {"title": "Oral Dis", "issn": "1601-0825", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1111/odi.13874", "pmid": "33844386", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-13T10:22:50.951Z", "modified": "2021-04-13T10:23:14.796Z"}, {"entity": "publication", "iuid": "0a5e0740e18b4707946abdb229678dc8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a5e0740e18b4707946abdb229678dc8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a5e0740e18b4707946abdb229678dc8"}}, "title": "Management of endocrine surgical disorders during COVID-19 pandemic: expert opinion for non-surgical options.", "authors": [{"family": "Agcaoglu", "given": "Orhan", "initials": "O"}, {"family": "Sezer", "given": "Atakan", "initials": "A"}, {"family": "Makay", "given": "Ozer", "initials": "O"}, {"family": "Erdogan", "given": "Murat Faik", "initials": "MF"}, {"family": "Bayram", "given": "Fahri", "initials": "F"}, {"family": "Guldiken", "given": "Sibel", "initials": "S"}, {"family": "Raffaelli", "given": "Marco", "initials": "M"}, {"family": "Sonmez", "given": "Yusuf Alper", "initials": "YA"}, {"family": "Lee", "given": "Yong-Sang", "initials": "YS"}, {"family": "Vamvakidis", "given": "Kyriakos", "initials": "K"}, {"family": "Mihai", "given": "Radu", "initials": "R"}, {"family": "Duh", "given": "Quan-Yang", "initials": "QY"}, {"family": "Akinci", "given": "Baris", "initials": "B"}, {"family": "Alagol", "given": "Faruk", "initials": "F"}, {"family": "Almquist", "given": "Martin", "initials": "M"}, {"family": "Barczynski", "given": "Marcin", "initials": "M"}, {"family": "Bayraktaroglu", "given": "Taner", "initials": "T"}, {"family": "Berber", "given": "Eren", "initials": "E"}, {"family": "Bukey", "given": "Yusuf", "initials": "Y"}, {"family": "Cakmak", "given": "Guldeniz Karadeniz", "initials": "GK"}, {"family": "Canturk", "given": "Nuh Zafer", "initials": "NZ"}, {"family": "Canturk", "given": "Zeynep", "initials": "Z"}, {"family": "Celik", "given": "Mehmet", "initials": "M"}, {"family": "Celik", "given": "Ozlem", "initials": "O"}, {"family": "Ceyhan", "given": "Banu Ozturk", "initials": "BO"}, {"family": "Cherenko", "given": "Sergii", "initials": "S"}, {"family": "Clerici", "given": "Thomas", "initials": "T"}, {"family": "Coombes", "given": "David Scott", "initials": "DS"}, {"family": "Demircan", "given": "Orhan", "initials": "O"}, {"family": "Deyneli", "given": "Oguzhan", "initials": "O"}, {"family": "Dionigi", "given": "Gianlorenzo", "initials": "G"}, {"family": "Emre", "given": "Ali Ugur", "initials": "AU"}, {"family": "Erbil", "given": "Yesim", "initials": "Y"}, {"family": "Filiz", "given": "Ali Ilker", "initials": "AI"}, {"family": "Gozu", "given": "Hulya Il\u0131ksu", "initials": "HI"}, {"family": "Gurdal", "given": "Sibel Ozkan", "initials": "SO"}, {"family": "Gurleyik", "given": "Gunay", "initials": "G"}, {"family": "Haciyanli", "given": "Mehmet", "initials": "M"}, {"family": "Kebudi", "given": "Abut", "initials": "A"}, {"family": "Kim", "given": "Seokmo", "initials": "S"}, {"family": "Koutelidakis", "given": "Giannis", "initials": "G"}, {"family": "Kuru", "given": "Bekir", "initials": "B"}, {"family": "Mert", "given": "Meral", "initials": "M"}, {"family": "Oruk", "given": "Guzide Gonca", "initials": "GG"}, {"family": "Ozbas", "given": "Serdar", "initials": "S"}, {"family": "Palazzo", "given": "Fausto", "initials": "F"}, {"family": "Pandev", "given": "Rumen", "initials": "R"}, {"family": "Riss", "given": "Phillip", "initials": "P"}, {"family": "Sabuncu", "given": "Tevfik", "initials": "T"}, {"family": "Sahin", "given": "Ibrahim", "initials": "I"}, {"family": "Sakman", "given": "Gurhan", "initials": "G"}, {"family": "Saygili", "given": "Fusun", "initials": "F"}, {"family": "Senyurek", "given": "Yasemin Giles", "initials": "YG"}, {"family": "Sleptsov", "given": "Ilya", "initials": "I"}, {"family": "Van Slycke", "given": "Sam", "initials": "S"}, {"family": "Teksoz", "given": "Serkan", "initials": "S"}, {"family": "Terzioglu", "given": "Tarik", "initials": "T"}, {"family": "Tezelman", "given": "Serdar", "initials": "S"}, {"family": "Tunca", "given": "Fatih", "initials": "F"}, {"family": "Ugurlu", "given": "Mustafa Umit", "initials": "MU"}, {"family": "Uludag", "given": "Mehmet", "initials": "M"}, {"family": "Villar-Del-Moral", "given": "Jesus", "initials": "J"}, {"family": "Vriens", "given": "Menno", "initials": "M"}, {"family": "Yazici", "given": "Dilek", "initials": "D"}], "type": "journal article", "published": "2021-04-11", "journal": {"title": "Updates Surg", "issn": "2038-3312", "volume": null, "issue": null, "issn-l": null}, "abstract": "The COVID-19 pandemic brought unprecedented conditions for overall health care systems by restricting resources for non-COVID-19 patients. As the burden of the disease escalates, routine elective surgeries are being cancelled. The aim of this paper was to provide a guideline for management of endocrine surgical disorders during a pandemic.\n\nWe used Delphi method with a nine-scale Likert scale on two rounds of voting involving 64 experienced eminent surgeons and endocrinologists who had the necessary experience to provide insight on endocrine disorder management. All voting was done by email using a standard questionnaire.\n\nOverall, 37 recommendations were voted on. In two rounds, all recommendations reached an agreement and were either endorsed or rejected. Endorsed statements include dietary change in primary hyperparathyroidism, Cinacalcet treatment in secondary hyperparathyroidism, alpha-blocker administration for pheochromocytoma, methimazole \u00b1 \u03b2-blocker combination for Graves' disease, and follow-up for fine-needle aspiration results of thyroid nodules indicated as Bethesda 3-4 cytological results and papillary microcarcinoma.\n\nThis survey summarizes expert opinion for the management of endocrine surgical conditions during unprecedented times when access to surgical treatment is severely disrupted. The statements are not applicable in circumstances in which surgical treatment is possible.", "doi": "10.1007/s13304-021-00979-8", "pmid": "33840069", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s13304-021-00979-8"}], "notes": [], "created": "2021-04-12T15:37:06.442Z", "modified": "2021-04-12T15:37:06.457Z"}, {"entity": "publication", "iuid": "0093b6ff3d9e4e7d9eb384ae94e166c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0093b6ff3d9e4e7d9eb384ae94e166c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0093b6ff3d9e4e7d9eb384ae94e166c5"}}, "title": "Suggestions for Shaping Tinnitus Service Provision in Western Europe: Lessons from the COVID-19 Pandemic.", "authors": [{"family": "Beukes", "given": "Eldr\u00e9 W", "initials": "EW"}, {"family": "Lourenco", "given": "Matheus P C G", "initials": "MPCG"}, {"family": "Biot", "given": "Lana", "initials": "L"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Kaldo", "given": "Viktor", "initials": "V"}, {"family": "Manchaiah", "given": "Vinaya", "initials": "V"}, {"family": "Jacquemin", "given": "Laure", "initials": "L"}], "type": "journal article", "published": "2021-04-10", "journal": {"title": "Int J Clin Pract", "issn": "1742-1241", "volume": null, "issue": null, "pages": "e14196", "issn-l": null}, "abstract": "Tinnitus severity has been exacerbated due to the COVID-19 pandemic and those with tinnitus require additional support. Such support should be informed by patient preferences and needs. The objective of this study was to gather information from individuals with tinnitus living in Europe to inform stakeholders of the (i) support they needed in relation to changes associated with the COVID-19 pandemic, and (ii) suggestions regarding tinnitus care for the future.\n\nA cross-sectional mixed methods study design was used using closed and open-ended questions via an online survey. Data was gathered from 710 adults experiencing tinnitus in Western Europe, with the majority living in The Netherlands, Belgium, and Sweden. Data were analysed using qualitative content analysis and descriptive statistics.\n\nThose with tinnitus indicated the following support needs during the pandemic (a) support for tinnitus, (b) support for hearing-related difficulties, (c) social support, and (d) pandemic-related support. Five directions for future tinnitus care were provided, namely (a) need for understanding professional support and access to multidisciplinary experts, (b) greater range of therapies and resources, (c) access to more information about tinnitus, (d) prioritizing tinnitus research, and (e) more support for hearing protection and hearing loss prevention CONCLUSIONS: The findings point to the need for accessible (remote), patient-centred, suitable and evidence-based tinnitus care. Insights from the current study can be used by various stakeholders including clinical practitioners and tinnitus support services to ensure those with tinnitus have access to the help and support required in order to reduce service provision insufficiencies.", "doi": "10.1111/ijcp.14196", "pmid": "33837639", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-12T15:38:24.625Z", "modified": "2021-04-12T15:38:24.647Z"}, {"entity": "publication", "iuid": "f0c96d0826084273911cf71b16584504", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f0c96d0826084273911cf71b16584504.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f0c96d0826084273911cf71b16584504"}}, "title": "Real-world evidence and product development: Opportunities, challenges and risk mitigation.", "authors": [{"family": "Naidoo", "given": "Poobalan", "initials": "P"}, {"family": "Bouharati", "given": "C\u00e9lia", "initials": "C"}, {"family": "Rambiritch", "given": "Virendra", "initials": "V"}, {"family": "Jose", "given": "Nadina", "initials": "N"}, {"family": "Karamchand", "given": "Sumanth", "initials": "S"}, {"family": "Chilton", "given": "Robert", "initials": "R"}, {"family": "Leisegang", "given": "Rory", "initials": "R"}], "type": "journal article", "published": "2021-04-09", "journal": {"title": "Wien Klin Wochenschr", "issn": "0043-5325", "volume": null, "issue": null, "issn-l": null}, "abstract": "Real-world evidence (RWE) is derived from real-world data (RWD) sources including electronic health records, claims data, registries (disease, product) and pragmatic clinical trials. The importance of RWE derived from RWD has been once again demonstrated during the coronavirus disease 2019 (COVID-19) pandemic, as it can improve patient care by complementing information obtained from traditional clinical trial programs. Additionally, RWE can generate insights into disease mechanisms, epidemiology, patient flows in and out of healthcare systems, and drivers and barriers to optimal clinical care in real-world settings. Identifying unmet medical needs is crucial as it often can inform which investigational new drugs enter clinical trial testing, and RWE studies from hospital settings have contributed substantial progress here. RWE can also optimize the design of clinical studies, inform benefit risk assessments and use networks of pragmatic studies to help with clinical trial feasibilities and eventual trial initiation. The challenges of RWD include data quality, reproducibility and accuracy which may affect validity. RWD and RWE must be fit for purpose and one must be cognizant of inherent biases.", "doi": "10.1007/s00508-021-01851-w", "pmid": "33837463", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00508-021-01851-w"}], "notes": [], "created": "2021-04-12T16:08:25.904Z", "modified": "2021-04-12T16:08:57.222Z"}, {"entity": "publication", "iuid": "7e93d0de8ee847b78624def331e2cbe7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e93d0de8ee847b78624def331e2cbe7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e93d0de8ee847b78624def331e2cbe7"}}, "title": "Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial.", "authors": [{"family": "Ramakrishnan", "given": "Sanjay", "initials": "S"}, {"family": "Nicolau", "given": "Dan V", "initials": "DV"}, {"family": "Langford", "given": "Beverly", "initials": "B"}, {"family": "Mahdi", "given": "Mahdi", "initials": "M"}, {"family": "Jeffers", "given": "Helen", "initials": "H"}, {"family": "Mwasuku", "given": "Christine", "initials": "C"}, {"family": "Krassowska", "given": "Karolina", "initials": "K"}, {"family": "Fox", "given": "Robin", "initials": "R"}, {"family": "Binnian", "given": "Ian", "initials": "I"}, {"family": "Glover", "given": "Victoria", "initials": "V"}, {"family": "Bright", "given": "Stephen", "initials": "S"}, {"family": "Butler", "given": "Christopher", "initials": "C"}, {"family": "Cane", "given": "Jennifer L", "initials": "JL"}, {"family": "Halner", "given": "Andreas", "initials": "A"}, {"family": "Matthews", "given": "Philippa C", "initials": "PC"}, {"family": "Donnelly", "given": "Louise E", "initials": "LE"}, {"family": "Simpson", "given": "Jodie L", "initials": "JL"}, {"family": "Baker", "given": "Jonathan R", "initials": "JR"}, {"family": "Fadai", "given": "Nabil T", "initials": "NT"}, {"family": "Peterson", "given": "Stefan", "initials": "S"}, {"family": "Bengtsson", "given": "Thomas", "initials": "T"}, {"family": "Barnes", "given": "Peter J", "initials": "PJ"}, {"family": "Russell", "given": "Richard E K", "initials": "REK"}, {"family": "Bafadhel", "given": "Mona", "initials": "M"}], "type": "journal article", "published": "2021-04-09", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "volume": null, "issue": null, "issn-l": "2213-2600"}, "abstract": "Multiple early reports of patients admitted to hospital with COVID-19 showed that patients with chronic respiratory disease were significantly under-represented in these cohorts. We hypothesised that the widespread use of inhaled glucocorticoids among these patients was responsible for this finding, and tested if inhaled glucocorticoids would be an effective treatment for early COVID-19.\n\nWe performed an open-label, parallel-group, phase 2, randomised controlled trial (Steroids in COVID-19; STOIC) of inhaled budesonide, compared with usual care, in adults within 7 days of the onset of mild COVID-19 symptoms. The trial was done in the community in Oxfordshire, UK. Participants were randomly assigned to inhaled budsonide or usual care stratified for age (\u226440 years or >40 years), sex (male or female), and number of comorbidities (\u22641 and \u22652). Randomisation was done using random sequence generation in block randomisation in a 1:1 ratio. Budesonide dry powder was delivered using a turbohaler at a dose of 800 \u03bcg per actuation. Participants were asked to take two inhalations twice a day until symptom resolution. The primary endpoint was COVID-19-related urgent care visit, including emergency department assessment or hospitalisation, analysed for both the per-protocol and intention-to-treat (ITT) populations. The secondary outcomes were self-reported clinical recovery (symptom resolution), viral symptoms measured using the Common Cold Questionnare (CCQ) and the InFLUenza Patient Reported Outcome Questionnaire (FLUPro), body temperature, blood oxygen saturations, and SARS-CoV-2 viral load. The trial was stopped early after independent statistical review concluded that study outcome would not change with further participant enrolment. This trial is registered with ClinicalTrials.gov, NCT04416399.\n\nFrom July 16 to Dec 9, 2020, 167 participants were recruited and assessed for eligibility. 21 did not meet eligibility criteria and were excluded. 146 participants were randomly assigned-73 to usual care and 73 to budesonide. For the per-protocol population (n=139), the primary outcome occurred in ten (14%) of 70 participants in the budesonide group and one (1%) of 69 participant in the usual care group (difference in proportions 0\u00b7131, 95% CI 0\u00b7043 to 0\u00b7218; p=0\u00b7004). For the ITT population, the primary outcome occurred in 11 (15%) participants in the usual care group and two (3%) participants in the budesonide group (difference in proportions 0\u00b7123, 95% CI 0\u00b7033 to 0\u00b7213; p=0\u00b7009). The number needed to treat with inhaled budesonide to reduce COVID-19 deterioration was eight. Clinical recovery was 1 day shorter in the budesonide group compared with the usual care group (median 7 days [95% CI 6 to 9] in the budesonide group vs 8 days [7 to 11] in the usual care group; log-rank test p=0\u00b7007). The mean proportion of days with a fever in the first 14 days was lower in the budesonide group (2%, SD 6) than the usual care group (8%, SD 18; Wilcoxon test p=0\u00b7051) and the proportion of participants with at least 1 day of fever was lower in the budesonide group when compared with the usual care group. As-needed antipyretic medication was required for fewer proportion of days in the budesonide group compared with the usual care group (27% [IQR 0-50] vs 50% [15-71]; p=0\u00b7025) Fewer participants randomly assigned to budesonide had persistent symptoms at days 14 and 28 compared with participants receiving usual care (difference in proportions 0\u00b7204, 95% CI 0\u00b7075 to 0\u00b7334; p=0\u00b7003). The mean total score change in the CCQ and FLUPro over 14 days was significantly better in the budesonide group compared with the usual care group (CCQ mean difference -0\u00b712, 95% CI -0\u00b721 to -0\u00b702 [p=0\u00b7016]; FLUPro mean difference -0\u00b710, 95% CI -0\u00b721 to -0\u00b700 [p=0\u00b7044]). Blood oxygen saturations and SARS-CoV-2 load, measured by cycle threshold, were not different between the groups. Budesonide was safe, with only five (7%) participants reporting self-limiting adverse events.\n\nEarly administration of inhaled budesonide reduced the likelihood of needing urgent medical care and reduced time to recovery after early COVID-19.\n\nNational Institute for Health Research Biomedical Research Centre and AstraZeneca.", "doi": "10.1016/S2213-2600(21)00160-0", "pmid": "33844996", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(21)00160-0"}, {"db": "ClinicalTrials.gov", "key": "NCT04416399"}], "notes": [], "created": "2021-04-13T10:27:27.629Z", "modified": "2021-04-13T10:29:15.226Z"}, {"entity": "publication", "iuid": "a6fc4c855acb4c7a8eeaf164395a1590", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6fc4c855acb4c7a8eeaf164395a1590.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6fc4c855acb4c7a8eeaf164395a1590"}}, "title": "Evaluating and optimizing COVID-19 vaccination policies: a case study of Sweden", "authors": [{"family": "Sj\u00f6din", "given": "Henrik", "initials": "H"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}, {"family": "Britton", "given": "Tom", "initials": "T"}], "type": "posted-content", "published": "2021-04-09", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.07.21255026", "pmid": null, "labels": {"Type: Preprint": null, "Category: Other": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-14T05:09:10.154Z", "modified": "2021-04-21T08:35:40.996Z"}, {"entity": "publication", "iuid": "1ddde94149764d01800ae09c16c2abed", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ddde94149764d01800ae09c16c2abed.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ddde94149764d01800ae09c16c2abed"}}, "title": "Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19.", "authors": [{"family": "Gaziano", "given": "Liam", "initials": "L"}, {"family": "Giambartolomei", "given": "Claudia", "initials": "C"}, {"family": "Pereira", "given": "Alexandre C", "initials": "AC"}, {"family": "Gaulton", "given": "Anna", "initials": "A"}, {"family": "Posner", "given": "Daniel C", "initials": "DC"}, {"family": "Swanson", "given": "Sonja A", "initials": "SA"}, {"family": "Ho", "given": "Yuk-Lam", "initials": "Y"}, {"family": "Iyengar", "given": "Sudha K", "initials": "SK"}, {"family": "Kosik", "given": "Nicole M", "initials": "NM"}, {"family": "Vujkovic", "given": "Marijana", "initials": "M"}, {"family": "Gagnon", "given": "David R", "initials": "DR"}, {"family": "Bento", "given": "A Patr\u00edcia", "initials": "AP"}, {"family": "Barrio-Hernandez", "given": "Inigo", "initials": "I"}, {"family": "R\u00f6nnblom", "given": "Lars", "initials": "L"}, {"family": "Hagberg", "given": "Niklas", "initials": "N"}, {"family": "Lundtoft", "given": "Christian", "initials": "C"}, {"family": "Langenberg", "given": "Claudia", "initials": "C"}, {"family": "Pietzner", "given": "Maik", "initials": "M"}, {"family": "Valentine", "given": "Dennis", "initials": "D"}, {"family": "Gustincich", "given": "Stefano", "initials": "S"}, {"family": "Tartaglia", "given": "Gian Gaetano", "initials": "GG"}, {"family": "Allara", "given": "Elias", "initials": "E"}, {"family": "Surendran", "given": "Praveen", "initials": "P"}, {"family": "Burgess", "given": "Stephen", "initials": "S"}, {"family": "Zhao", "given": "Jing Hua", "initials": "JH"}, {"family": "Peters", "given": "James E", "initials": "JE"}, {"family": "Prins", "given": "Bram P", "initials": "BP"}, {"family": "Angelantonio", "given": "Emanuele Di", "initials": "ED"}, {"family": "Devineni", "given": "Poornima", "initials": "P"}, {"family": "Shi", "given": "Yunling", "initials": "Y"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "DuVall", "given": "Scott L", "initials": "SL"}, {"family": "Garcon", "given": "Helene", "initials": "H"}, {"family": "Thomann", "given": "Lauren O", "initials": "LO"}, {"family": "Zhou", "given": "Jin J", "initials": "JJ"}, {"family": "Gorman", "given": "Bryan R", "initials": "BR"}, {"family": "Huffman", "given": "Jennifer E", "initials": "JE"}, {"family": "O'Donnell", "given": "Christopher J", "initials": "CJ"}, {"family": "Tsao", "given": "Philip S", "initials": "PS"}, {"family": "Beckham", "given": "Jean C", "initials": "JC"}, {"family": "Pyarajan", "given": "Saiju", "initials": "S"}, {"family": "Muralidhar", "given": "Sumitra", "initials": "S"}, {"family": "Huang", "given": "Grant D", "initials": "GD"}, {"family": "Ramoni", "given": "Rachel", "initials": "R"}, {"family": "Beltrao", "given": "Pedro", "initials": "P"}, {"family": "Danesh", "given": "John", "initials": "J"}, {"family": "Hung", "given": "Adriana M", "initials": "AM"}, {"family": "Chang", "given": "Kyong-Mi", "initials": "K"}, {"family": "Sun", "given": "Yan V", "initials": "YV"}, {"family": "Joseph", "given": "Jacob", "initials": "J"}, {"family": "Leach", "given": "Andrew R", "initials": "AR"}, {"family": "Edwards", "given": "Todd L", "initials": "TL"}, {"family": "Cho", "given": "Kelly", "initials": "K"}, {"family": "Gaziano", "given": "J Michael", "initials": "JM"}, {"family": "Butterworth", "given": "Adam S", "initials": "AS"}, {"family": "Casas", "given": "Juan P", "initials": "JP"}, {"family": "VA Million Veteran Program COVID-19 Science Initiative", "given": "", "initials": ""}], "type": "journal article", "published": "2021-04-09", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956", "volume": "27", "issue": "4", "pages": "668-676"}, "abstract": "Drug repurposing provides a rapid approach to meet the urgent need for therapeutics to address COVID-19. To identify therapeutic targets relevant to COVID-19, we conducted Mendelian randomization analyses, deriving genetic instruments based on transcriptomic and proteomic data for 1,263 actionable proteins that are targeted by approved drugs or in clinical phase of drug development. Using summary statistics from the Host Genetics Initiative and the Million Veteran Program, we studied 7,554 patients hospitalized with COVID-19 and >1 million controls. We found significant Mendelian randomization results for three proteins (ACE2, P = 1.6 \u00d7 10 -6; IFNAR2, P = 9.8 \u00d7 10-11 and IL-10RB, P = 2.3 \u00d7 10-14) using cis-expression quantitative trait loci genetic instruments that also had strong evidence for colocalization with COVID-19 hospitalization. To disentangle the shared expression quantitative trait loci signal for IL10RB and IFNAR2, we conducted phenome-wide association scans and pathway enrichment analysis, which suggested that IFNAR2 is more likely to play a role in COVID-19 hospitalization. Our findings prioritize trials of drugs targeting IFNAR2 and ACE2 for early management of COVID-19.", "doi": "10.1038/s41591-021-01310-z", "pmid": "33837377", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-021-01310-z"}, {"db": "GTEx project", "key": "https://gtexportal.org/home/.", "description": "GTEx project v.8 data"}, {"db": "CheMBL", "key": "https://www.ebi.ac.uk/chembl/", "description": "CheMBL database used to identify 1,263 human proteins as \u2018actionable\u2019 (therapeutic targets of approved or clinical-stage drugs) for SARS-COV2"}, {"db": "Fenland-SomaLogic protein GWAS data", "key": "https://omicscience.org/apps/covidpgwas/", "description": null}, {"db": "COVID-19 hospitalization data", "key": "https://www.covid19hg.org/", "description": "HGI COVID-19 hospitalization summary statistics"}, {"db": "phenoscanner", "key": "http://www.phenoscanner.medschl.cam.ac.uk/", "description": "PhenoScanner results for searching proteins, traits and diseases"}], "notes": [], "created": "2021-04-12T16:09:55.811Z", "modified": "2021-11-18T09:22:55.307Z"}, {"entity": "publication", "iuid": "e95d0be8d9a041e7bd1859fa613ee7cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e95d0be8d9a041e7bd1859fa613ee7cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e95d0be8d9a041e7bd1859fa613ee7cc"}}, "title": "Safety of Esophageal Cancer Surgery During the First Wave of the COVID-19 Pandemic in Europe: A Multicenter Study.", "authors": [{"family": "Borgstein", "given": "Alexander B J", "initials": "ABJ"}, {"family": "Brunner", "given": "Stefanie", "initials": "S"}, {"family": "Hayami", "given": "Masaru", "initials": "M"}, {"family": "Moons", "given": "Johnny", "initials": "J"}, {"family": "Fuchs", "given": "Hans", "initials": "H"}, {"family": "Eshuis", "given": "Wietse J", "initials": "WJ"}, {"family": "Gisbertz", "given": "Suzanne S", "initials": "SS"}, {"family": "Bruns", "given": "Christiane J", "initials": "CJ"}, {"family": "Nafteux", "given": "Philippe", "initials": "P"}, {"family": "Nilsson", "given": "Magnus", "initials": "M"}, {"family": "Schr\u00f6der", "given": "Wolfgang", "initials": "W"}, {"family": "van Berge Henegouwen", "given": "Mark I", "initials": "MI"}], "type": "journal article", "published": "2021-04-08", "journal": {"title": "Ann Surg Oncol", "issn": "1534-4681", "volume": null, "issue": null, "issn-l": null}, "abstract": "Many hospitals postponed elective surgical care during the first wave of the coronavirus disease 2019 (COVID-19) pandemic. Some centers continued elective surgery, including esophageal cancer surgery, with the use of preoperative screening methods; however, there is no evidence supporting the safety of this strategy as postoperative outcomes after esophageal cancer surgery during the COVID-19 pandemic have not yet been investigated.\n\nThis multicenter study in four European tertiary esophageal cancer referral centers included consecutive adult patients undergoing elective esophageal cancer surgery from a prospectively maintained database in a COVID-19 pandemic cohort (1 March 2020-31 May 2020) and a control cohort (1 October 2019-29 February 2020). The primary outcome was the rate of respiratory failure requiring mechanical ventilation.\n\nThe COVID-19 cohort consisted of 139 patients, versus 168 patients in the control cohort. There was no difference in the rate of respiratory failure requiring mechanical ventilation (13.7% vs. 8.3%, p = 0.127) and number of pulmonary complications (32.4% vs. 29.9%, p = 0.646) between the COVID-19 cohort and the control cohort. Overall, postoperative morbidity and mortality rates were comparable between both cohorts. History taking and reverse transcription polymerase chain reaction (RT-PCR) were used as preoperative screening methods to detect a possible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in all centers. No patients were diagnosed with COVID-19 pre- or postoperatively.\n\nEsophageal cancer surgery during the first wave of the COVID-19 pandemic was not associated with an increase in pulmonary complications as no patients were diagnosed with COVID-19. Esophageal cancer surgery can be performed safely with the use of adequate preoperative SARS-CoV-2 screening methods.", "doi": "10.1245/s10434-021-09886-z", "pmid": "33830357", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1245/s10434-021-09886-z"}], "notes": [], "created": "2021-04-09T16:45:24.369Z", "modified": "2021-04-09T16:45:24.393Z"}, {"entity": "publication", "iuid": "0c3bea1d568149e89b08f349a0786114", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c3bea1d568149e89b08f349a0786114.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c3bea1d568149e89b08f349a0786114"}}, "title": "Platelet count rose while D-dimer levels dropped as deaths and thrombosis declined, an observational study on anticoagulation shift in COVID-19.", "authors": [{"family": "Sj\u00f6str\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Wers\u00e4ll", "given": "Johanna", "initials": "J"}, {"family": "Warnqvist", "given": "Anna", "initials": "A"}, {"family": "Farm", "given": "Maria", "initials": "M"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Oldner", "given": "Anders", "initials": "A"}, {"family": "\u00c5gren", "given": "Anna", "initials": "A"}, {"family": "Antovic", "given": "Jovan P", "initials": "JP"}, {"family": "Bruzelius", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-04-08", "journal": {"title": "Thromb Haemost", "issn": "2567-689X", "volume": null, "issue": null, "issn-l": "0340-6245"}, "abstract": "High levels of D-dimer and low platelet counts are associated with poor outcome in COVID-19. As anticoagulation appeared to improve survival, hospital-wide recommendations regarding higher doses of anticoagulation was implemented 4/9/2020.\n\nTo investigate if trends in D-dimer levels and platelet counts associated with death, thrombosis, and the shift in anticoagulation.\n\nRetrospective cohort study of 429 patients with COVID-19 at Karolinska University Hospital. Information on D-dimer levels and platelet counts was obtained from laboratory databases and clinical data from medical records.\n\nThirty-day mortality and thrombosis rate was 19% and 18%, respectively. Pulmonary embolism was common; 65/83 (78%). Increased D-dimer levels the first week in hospital were significantly associated with death and thrombosis (OR 6.06; 95% Cl 2.10-17.5, and 3.11; 95% CI 1.20-8.10, respectively). If platelet count increased more than 35\u00d7109/L per day, the mortality and thrombotic risk decreased (OR 0.16; 95% CI 0.06-0.41, and OR 0.36; 95% CI 0.17-0.80). After implementation of updated hospital-wide recommendations, the daily mean significantly decreased regarding D-dimer levels while platelet counts rose; -1.93; 95% CI -1.00-2.87 mg/L FEU and 65; 95% CI 54-76 \u00d7109/L and significant risk reductions for death and thrombosis were observed; OR 0.48; 95% CI 0.25-0.92 and 0.35; 95% CI 0.17-0.72.\n\nIn contrast to D-dimer levels, increase of platelet count over the first week in-hospital was associated with improved survival and reduced thrombotic risk. The daily mean levels of D-dimer dropped while the platelet counts rose, coinciding with increased anticoagulation and a decline in thrombotic burden and mortality.", "doi": "10.1055/a-1477-3829", "pmid": "33831964", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-09T16:47:21.673Z", "modified": "2021-04-09T16:47:21.683Z"}, {"entity": "publication", "iuid": "7419a7484d754917952a7b310334a8ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7419a7484d754917952a7b310334a8ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7419a7484d754917952a7b310334a8ef"}}, "title": "Estimation of Excess Mortality and Years of Life Lost to COVID-19 in Norway and Sweden between March and November 2020.", "authors": [{"family": "Rypdal", "given": "Martin", "initials": "M", "orcid": "0000-0003-0053-665X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eea43d9f775e446680aff49c4caf4a6e.json"}}, {"family": "Rypdal", "given": "Kristoffer", "initials": "K", "orcid": "0000-0001-9306-5441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf10bf2f114a497e990038fd1c8d9248.json"}}, {"family": "L\u00f8vsletten", "given": "Ola", "initials": "O", "orcid": "0000-0001-9483-9621", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3912eef1009b48c69b67fd71687b9776.json"}}, {"family": "S\u00f8rbye", "given": "Sigrunn Holbek", "initials": "SH", "orcid": "0000-0002-5818-1508", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4ca8694ab6947bfa1e8f7fdc9d084ea.json"}}, {"family": "Ytterstad", "given": "Elinor", "initials": "E", "orcid": "0000-0002-1203-1491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33d836747a854f1592d920fa05bf7031.json"}}, {"family": "Bianchi", "given": "Filippo Maria", "initials": "FM", "orcid": "0000-0002-7145-3846", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cc4d12290c64a3f8b406347f52f8c9b.json"}}], "type": "journal article", "published": "2021-04-08", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "8", "issn-l": null}, "abstract": "We estimate the weekly excess all-cause mortality in Norway and Sweden, the years of life lost (YLL) attributed to COVID-19 in Sweden, and the significance of mortality displacement. We computed the expected mortality by taking into account the declining trend and the seasonality in mortality in the two countries over the past 20 years. From the excess mortality in Sweden in 2019/20, we estimated the YLL attributed to COVID-19 using the life expectancy in different age groups. We adjusted this estimate for possible displacement using an auto-regressive model for the year-to-year variations in excess mortality. We found that excess all-cause mortality over the epidemic year, July 2019 to July 2020, was 517 (95%CI = (12, 1074)) in Norway and 4329 [3331, 5325] in Sweden. There were 255 COVID-19 related deaths reported in Norway, and 5741 in Sweden, that year. During the epidemic period of 11 March-11 November, there were 6247 reported COVID-19 deaths and 5517 (4701, 6330) excess deaths in Sweden. We estimated that the number of YLL attributed to COVID-19 in Sweden was 45,850 [13,915, 80,276] without adjusting for mortality displacement and 43,073 (12,160, 85,451) after adjusting for the displacement accounted for by the auto-regressive model. In conclusion, we find good agreement between officially recorded COVID-19 related deaths and all-cause excess deaths in both countries during the first epidemic wave and no significant mortality displacement that can explain those deaths.", "doi": "10.3390/ijerph18083913", "pmid": "33917872", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8068261"}, {"db": "pii", "key": "ijerph18083913"}], "notes": [], "created": "2023-01-13T13:43:05.800Z", "modified": "2023-01-13T13:43:07.279Z"}, {"entity": "publication", "iuid": "7f23907c2d4842f3afbc5d09b9b23b51", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f23907c2d4842f3afbc5d09b9b23b51.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f23907c2d4842f3afbc5d09b9b23b51"}}, "title": "Detection of SARS-CoV-2 RNA in the Danube River in Serbia associated with the discharge of untreated wastewaters.", "authors": [{"family": "Kolarevi\u0107", "given": "Stoimir", "initials": "S"}, {"family": "Micsinai", "given": "Adrienn", "initials": "A"}, {"family": "Sz\u00e1nt\u00f3-Eg\u00e9sz", "given": "R\u00e9ka", "initials": "R"}, {"family": "Luk\u00e1cs", "given": "Alena", "initials": "A"}, {"family": "Kra\u010dun-Kolarevi\u0107", "given": "Margareta", "initials": "M"}, {"family": "Lundy", "given": "Lian", "initials": "L"}, {"family": "Kirschner", "given": "Alexander K T", "initials": "AKT"}, {"family": "Farnleitner", "given": "Andreas H", "initials": "AH"}, {"family": "Djukic", "given": "Aleksandar", "initials": "A"}, {"family": "\u010coli\u0107", "given": "Jasna", "initials": "J"}, {"family": "Nenin", "given": "Tanja", "initials": "T"}, {"family": "Sunjog", "given": "Karolina", "initials": "K"}, {"family": "Paunovi\u0107", "given": "Momir", "initials": "M"}], "type": "journal article", "published": "2021-04-08", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "issn-l": "0048-9697", "volume": "783", "issue": null, "pages": "146967"}, "abstract": "In Serbia less than 13% of collected municipal wastewaters is being treated before their release in the environment. This includes all municipal wastewater discharges from Belgrade (capital city of Serbia; population 1,700,000). Previous research has identified the impacts of raw wastewater discharges from Belgrade on the Danube River, and this study investigated if such discharges also provided a pathway for SARS-CoV-2 RNA material. Samples were collected during the most critical circumstances that occurred so far within the COVID-19 pandemics in Serbia. Grab and composite samples were collected in December 2020, during the peak of the third wave (in terms of reported cases) at the site which receives the wastewater loads in Belgrade. Grab samples collected upstream and downstream of Belgrade were also analyzed. RNA was quantified using RT-qPCR with primer sets targeting nucleocapsid (N1 and N2) and envelope (E) protein genes. SARS-CoV-2 RNA (5.97 \u00d7 10 3 to 1.32 \u00d7 104 copies/L) was detected only in samples collected at the site strongly impacted by the wastewaters where all three applied primer sets gave positive signals. Determined concentrations correspond to those reported in wastewater influents sampled at treatment plants in other countries indicating an epidemiological indicator function of used approach for rivers with high pollution loads in countries with poor wastewater treatment.", "doi": "10.1016/j.scitotenv.2021.146967", "pmid": "33865136", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(21)02037-4"}], "notes": [], "created": "2021-04-19T10:40:03.905Z", "modified": "2021-06-21T14:49:12.299Z"}, {"entity": "publication", "iuid": "d2d1266ccd71494e829e3db102c467fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d2d1266ccd71494e829e3db102c467fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d2d1266ccd71494e829e3db102c467fa"}}, "title": "Acceptability of COVID-19 Vaccine in Africa", "authors": [{"family": "Sevidzem Wirsiy", "given": "Frankline", "initials": "F"}, {"family": "Nkfusai", "given": "Ngwayu Claude", "initials": "NC"}, {"family": "Ebot Ako-Arrey", "given": "Denis", "initials": "D"}, {"family": "Kenfack Dongmo", "given": "Esther", "initials": "E"}, {"family": "Titu Manjong", "given": "Florence", "initials": "F"}, {"family": "Nambile Cumber", "given": "Samuel", "initials": "S"}], "type": "journal-article", "published": "2021-04-08", "journal": {"title": "Int J MCH AIDS", "issn": "2161-864X", "volume": "10", "issue": "1", "pages": "134-138", "issn-l": null}, "abstract": null, "doi": "10.21106/ijma.482", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-04-20T17:55:23.466Z", "modified": "2021-04-20T17:55:23.489Z"}, {"entity": "publication", "iuid": "6c44a627afce4e37869d9a48b8ae9616", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c44a627afce4e37869d9a48b8ae9616.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c44a627afce4e37869d9a48b8ae9616"}}, "title": "Transmission of SARS-Cov-2 and other enveloped viruses to the environment through protective gear: a brief review.", "authors": [{"family": "Petrosino", "given": "Francesco", "initials": "F"}, {"family": "Mukherjee", "given": "Debolina", "initials": "D"}, {"family": "Coppola", "given": "Gerardo", "initials": "G"}, {"family": "Gaudio", "given": "Maria Teresa", "initials": "MT"}, {"family": "Curcio", "given": "Stefano", "initials": "S"}, {"family": "Calabro", "given": "Vincenza", "initials": "V"}, {"family": "Marra", "given": "Francesco", "initials": "F"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Pal", "given": "Umapada", "initials": "U"}, {"family": "Kh\u00e9lifi", "given": "Nabil", "initials": "N"}, {"family": "Chakraborty", "given": "Sudip", "initials": "S"}], "type": "journal article", "published": "2021-04-07", "journal": {"title": "EuroMediterr J Environ Integr", "issn": "2365-7448", "volume": "6", "issue": "2", "pages": "48", "issn-l": null}, "abstract": "Over the past two decades, several deadly viral epidemics have emerged, which have placed humanity in danger. Previous investigations have suggested that viral diseases can spread through contaminants or contaminated surfaces. The transmission of viruses via polluted surfaces relies upon their capacity to maintain their infectivity while they are in the environment. Here, a range of materials that are widely used to manufacture personal protective equipment (PPE) are summarized, as these offer effective disinfection solutions and are the environmental variables that influence virus survival. Infection modes and prevention as well as disinfection and PPE disposal strategies are discussed. A coronavirus-like enveloped virus can live in the environment after being discharged from a host organism until it infects another healthy individual. Transmission of enveloped viruses such as SARS-CoV-2 can occur even without direct contact, although detailed knowledge of airborne routes and other indirect transmission paths is still lacking. Ground transmission of viruses is also possible via wastewater discharges. While enveloped viruses can contaminate potable water and wastewater through human excretions such as feces and droplets, careless PPE disposal can also lead to their transmission into our environment. This paper also highlights the possibility that viruses can be transmitted into the environment from PPE kits used by healthcare and emergency service personnel. A simulation-based approach was developed to understand the transport mechanism for coronavirus and similar enveloped viruses in the environment through porous media, and preliminary results from this model are presented here. Those results indicate that viruses can move through porous soil and eventually contaminate groundwater. This paper therefore underlines the importance of proper PPE disposal by healthcare workers in the Mediterranean region and around the world.", "doi": "10.1007/s41207-021-00251-w", "pmid": "33842691", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "251"}, {"db": "pmc", "key": "PMC8024444"}], "notes": [], "created": "2021-04-13T09:37:59.682Z", "modified": "2021-04-13T10:15:55.648Z"}, {"entity": "publication", "iuid": "38721962da8b47b7ab73d1b984f6f0e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38721962da8b47b7ab73d1b984f6f0e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38721962da8b47b7ab73d1b984f6f0e8"}}, "title": "Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19", "authors": [{"family": "Klaric", "given": "Lucija", "initials": "L"}, {"family": "Gisby", "given": "Jack S", "initials": "JS"}, {"family": "Papadaki", "given": "Artemis", "initials": "A"}, {"family": "Muckian", "given": "Marisa D", "initials": "MD"}, {"family": "Macdonald-Dunlop", "given": "Erin", "initials": "E"}, {"family": "Zhao", "given": "Jing Hua", "initials": "JH"}, {"family": "Tokolyi", "given": "Alex", "initials": "A"}, {"family": "Persyn", "given": "Elodie", "initials": "E"}, {"family": "Pairo-Castineira", "given": "Erola", "initials": "E"}, {"family": "Morris", "given": "Andrew P", "initials": "AP"}, {"family": "Kalnapenkis", "given": "Anette", "initials": "A"}, {"family": "Richmond", "given": "Anne", "initials": "A"}, {"family": "Landini", "given": "Arianna", "initials": "A"}, {"family": "Hedman", "given": "\u00c5sa K", "initials": "\u00c5K"}, {"family": "Prins", "given": "Bram", "initials": "B"}, {"family": "Zanetti", "given": "Daniela", "initials": "D"}, {"family": "Wheeler", "given": "Eleanor", "initials": "E"}, {"family": "Kooperberg", "given": "Charles", "initials": "C"}, {"family": "Yao", "given": "Chen", "initials": "C"}, {"family": "Petrie", "given": "John R", "initials": "JR"}, {"family": "Fu", "given": "Jingyuan", "initials": "J"}, {"family": "Folkersen", "given": "Lasse", "initials": "L"}, {"family": "Walker", "given": "Mark", "initials": "M"}, {"family": "Magnusson", "given": "Martin", "initials": "M"}, {"family": "Eriksson", "given": "Niclas", "initials": "N"}, {"family": "Mattsson-Carlgren", "given": "Niklas", "initials": "N"}, {"family": "Timmers", "given": "Paul R H J", "initials": "PRHJ"}, {"family": "Hwang", "given": "Shih Jen", "initials": "SJ"}, {"family": "Enroth", "given": "Stefan", "initials": "S"}, {"family": "Gustafsson", "given": "Stefan", "initials": "S"}, {"family": "Vosa", "given": "Urmo", "initials": "U"}, {"family": "Chen", "given": "Yan", "initials": "Y"}, {"family": "Siegbahn", "given": "Agneta", "initials": "A"}, {"family": "Reiner", "given": "Alexander", "initials": "A"}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Thorand", "given": "Barbara", "initials": "B"}, {"family": "Gigante", "given": "Bruna", "initials": "B"}, {"family": "Hayward", "given": "Caroline", "initials": "C"}, {"family": "Herder", "given": "Christian", "initials": "C"}, {"family": "Gieger", "given": "Christian", "initials": "C"}, {"family": "Langenberg", "given": "Claudia", "initials": "C"}, {"family": "Levy", "given": "Daniel", "initials": "D"}, {"family": "Zhernakova", "given": "Daria V", "initials": "DV"}, {"family": "Smith", "given": "J Gustav", "initials": "JG"}, {"family": "Campbell", "given": "Harry", "initials": "H"}, {"family": "Sundstrom", "given": "Johan", "initials": "J"}, {"family": "Danesh", "given": "John", "initials": "J"}, {"family": "Micha\u00eblsson", "given": "Karl", "initials": "K"}, {"family": "Suhre", "given": "Karsten", "initials": "K"}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Wallentin", "given": "Lars", "initials": "L"}, {"family": "Padyukov", "given": "Leonid", "initials": "L"}, {"family": "Land\u00e9n", "given": "Mikael", "initials": "M"}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ"}, {"family": "G\u00f6teson", "given": "Andreas", "initials": "A"}, {"family": "Hansson", "given": "Oskar", "initials": "O"}, {"family": "Eriksson", "given": "Per", "initials": "P"}, {"family": "Strawbridge", "given": "Rona J", "initials": "RJ"}, {"family": "Assimes", "given": "Themistocles L", "initials": "TL"}, {"family": "Esko", "given": "Tonu", "initials": "T"}, {"family": "Gyllensten", "given": "Ulf", "initials": "U"}, {"family": "Baillie", "given": "J Kenneth", "initials": "JK"}, {"family": "Paul", "given": "Dirk S", "initials": "DS"}, {"family": "Joshi", "given": "Peter K", "initials": "PK"}, {"family": "Butterworth", "given": "Adam S", "initials": "AS"}, {"family": "M\u00e4larstig", "given": "Anders", "initials": "A"}, {"family": "Pirastu", "given": "Nicola", "initials": "N"}, {"family": "Wilson", "given": "James F", "initials": "JF"}, {"family": "Peters", "given": "James E", "initials": "JE"}], "type": "posted-content", "published": "2021-04-07", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.01.21254789", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "URL", "key": "https://www.medrxiv.org/node/330092.external-links.html", "description": "All data are available in the paper and supplementary material"}], "notes": [], "created": "2021-04-09T17:20:45.937Z", "modified": "2021-11-18T12:28:05.919Z"}, {"entity": "publication", "iuid": "009ec6accb344739ba8d2b672015151e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/009ec6accb344739ba8d2b672015151e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/009ec6accb344739ba8d2b672015151e"}}, "title": "Impact of COVID-19 on social media as perceived by the oncology community: results from a survey in collaboration with the European Society for Medical Oncology (ESMO) and the OncoAlert Network.", "authors": [{"family": "Morgan", "given": "G", "initials": "G"}, {"family": "Tagliamento", "given": "M", "initials": "M"}, {"family": "Lambertini", "given": "M", "initials": "M"}, {"family": "Devnani", "given": "B", "initials": "B"}, {"family": "Westphalen", "given": "B", "initials": "B"}, {"family": "Dienstmann", "given": "R", "initials": "R"}, {"family": "Bozovic-Spasojevic", "given": "I", "initials": "I"}, {"family": "Calles", "given": "A", "initials": "A"}, {"family": "Criscitiello", "given": "C", "initials": "C"}, {"family": "Curioni", "given": "A", "initials": "A"}, {"family": "Garcia", "given": "A M", "initials": "AM"}, {"family": "Lamarca", "given": "A", "initials": "A"}, {"family": "Pilotto", "given": "S", "initials": "S"}, {"family": "Scheffler", "given": "M", "initials": "M"}, {"family": "Strijbos", "given": "M", "initials": "M"}, {"family": "Wong", "given": "R", "initials": "R"}, {"family": "de Azambuja", "given": "E", "initials": "E"}, {"family": "Peters", "given": "S", "initials": "S"}], "type": "journal article", "published": "2021-04-07", "journal": {"title": "ESMO Open", "issn": "2059-7029", "volume": "6", "issue": "2", "pages": "100104", "issn-l": null}, "abstract": "The COVID-19 pandemic has impacted all aspects of modern-day oncology, including how stakeholders communicate through social media. We surveyed oncology stakeholders in order to assess their attitudes pertaining to social media and how it has been affected during the pandemic.\n\nA 40-item survey was distributed to stakeholders from 8 July to 22 July 2020 and was promoted through the European Society for Medical Oncology (ESMO) and the OncoAlert Network.\n\nOne thousand and seventy-six physicians and stakeholders took part in the survey. In total, 57.3% of respondents were medical oncologists, 50.6% aged <40 years, 50.8% of female gender and mostly practicing in Europe (51.5%). More than 90% of respondents considered social media a useful tool for distributing scientific information and for education. Most used social media to stay up to date on cancer care in general (62.5%) and cancer care during COVID-19 (61%) given the constant flow of information. Respondents also used social media to interact with other oncologists (78.8%) and with patients (34.4%). Overall, 61.1% of respondents were satisfied with the role that social media was playing during the COVID-19 pandemic. On the other hand, 41.1% of respondents reported trouble in discriminating between credible and less credible information and 30% stated social networks were a source of stress. For this reason, one-third of respondents reduced its use during the COVID-19 pandemic. Regarding meeting attendance, a total of 59.1% of responding physicians preferred in-person meetings to virtual ones, and 51.8% agreed that virtual meetings and social distancing could hamper effective collaboration.\n\nSocial media has a useful role in supporting cancer care and professional engagement in oncology. Although one-third of respondents reported reduced use of social media due to stress during the COVID-19 pandemic, the majority found social media useful to keep up to date and were satisfied with the role social media was playing during the pandemic.", "doi": "10.1016/j.esmoop.2021.100104", "pmid": "33838532", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2059-7029(21)00061-2"}], "notes": [], "created": "2021-04-12T15:37:58.350Z", "modified": "2021-04-12T15:37:58.364Z"}, {"entity": "publication", "iuid": "3b2eb5d7df4c423fb1850f747e0c19ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b2eb5d7df4c423fb1850f747e0c19ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b2eb5d7df4c423fb1850f747e0c19ee"}}, "title": "Extracorporeal Membrane Oxygenation in Patients With COVID-19: An International Multicenter Cohort Study.", "authors": [{"family": "Raasveld", "given": "Senta Jorinde", "initials": "SJ"}, {"family": "Delnoij", "given": "Thijs S R", "initials": "TSR"}, {"family": "Broman", "given": "Lars M", "initials": "LM"}, {"family": "Lansink-Hartgring", "given": "Annemieke Oude", "initials": "AO"}, {"family": "Hermans", "given": "Greet", "initials": "G"}, {"family": "De Troy", "given": "Erwin", "initials": "E"}, {"family": "Taccone", "given": "Fabio S", "initials": "FS"}, {"family": "Quintana Diaz", "given": "Manuel", "initials": "M"}, {"family": "van der Velde", "given": "Franciska", "initials": "F"}, {"family": "Miranda", "given": "Dinis Dos Reis", "initials": "DDR"}, {"family": "Scholten", "given": "Erik", "initials": "E"}, {"family": "ETALON Study Group", "given": "", "initials": ""}, {"family": "Vlaar", "given": "Alexander P J", "initials": "APJ"}], "type": "journal article", "published": "2021-04-07", "journal": {"title": "J Intensive Care Med", "issn": "1525-1489", "volume": null, "issue": null, "pages": "8850666211007063", "issn-l": null}, "abstract": "To report and compare the characteristics and outcomes of COVID-19 patients on extracorporeal membrane oxygenation (ECMO) to non-COVID-19 acute respiratory distress syndrome (ARDS) patients on ECMO.\n\nWe performed an international retrospective study of COVID-19 patients on ECMO from 13 intensive care units from March 1 to April 30, 2020. Demographic data, ECMO characteristics and clinical outcomes were collected. The primary outcome was to assess the complication rate and 28-day mortality; the secondary outcome was to compare patient and ECMO characteristics between COVID-19 patients on ECMO and non-COVID-19 related ARDS patients on ECMO (non-COVID-19; January 1, 2018 until July 31, 2019).\n\nDuring the study period 71 COVID-19 patients received ECMO, mostly veno-venous, for a median duration of 13 days (IQR 7-20). ECMO was initiated at 5 days (IQR 3-10) following invasive mechanical ventilation. Median PaO 2/FiO2 ratio prior to initiation of ECMO was similar in COVID-19 patients (58 mmHg [IQR 46-76]) and non-COVID-19 patients (53 mmHg [IQR 44-66]), the latter consisting of 48 patients. 28-day mortality was 37% in COVID-19 patients and 27% in non-COVID-19 patients. However, Kaplan-Meier curves showed that after a 100-day follow-up this non-significant difference resolves. Non-surviving COVID-19 patients were more acidotic prior to initiation ECMO, had a shorter ECMO run and fewer received muscle paralysis compared to survivors.\n\nNo significant differences in outcomes were found between COVID-19 patients on ECMO and non-COVID-19 ARDS patients on ECMO. This suggests that ECMO could be considered as a supportive therapy in case of refractory respiratory failure in COVID-19.", "doi": "10.1177/08850666211007063", "pmid": "33823709", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-09T16:37:56.539Z", "modified": "2021-04-09T16:38:10.777Z"}, {"entity": "publication", "iuid": "3b12c54aa1004277b287b04be74241cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b12c54aa1004277b287b04be74241cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b12c54aa1004277b287b04be74241cf"}}, "title": "Evaluation of 11 SARS-CoV-2 antibody tests by using samples from patients with defined IgG antibody titers.", "authors": [{"family": "Lagerqvist", "given": "Nina", "initials": "N"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Verner-Carlsson", "given": "Jenny", "initials": "J"}, {"family": "Olausson", "given": "Mikaela", "initials": "M"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Wigren Bystr\u00f6m", "given": "Julia", "initials": "J"}, {"family": "Monsen", "given": "Tor", "initials": "T"}, {"family": "Forsell", "given": "Mattias", "initials": "M"}, {"family": "Eriksson", "given": "Jenny", "initials": "J"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Ljunggren", "given": "Joel", "initials": "J"}, {"family": "Repo", "given": "Johanna", "initials": "J"}, {"family": "Kjerstadius", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Muradrasoli", "given": "Shaman", "initials": "S"}, {"family": "Brytting", "given": "Mia", "initials": "M"}, {"family": "Szekely Bj\u00f6rndal", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "\u00c5kerlund", "given": "Thomas", "initials": "T"}, {"family": "Nilsson", "given": "Charlotta", "initials": "C"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2021-04-07", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "7614"}, "abstract": "We evaluated the performance of 11 SARS-CoV-2 antibody tests using a reference set of heat-inactivated samples from 278 unexposed persons and 258 COVID-19 patients, some of whom contributed serial samples. The reference set included samples with a variation in SARS-CoV-2 IgG antibody titers, as determined by an in-house immunofluorescence assay (IFA). The five evaluated rapid diagnostic tests had a specificity of 99.0% and a sensitivity that ranged from 56.3 to 81.6% and decreased with low IFA IgG titers. The specificity was > 99% for five out of six platform-based tests, and when assessed using samples collected \u2265 22 days after symptom onset, two assays had a sensitivity of > 96%. These two assays also detected samples with low IFA titers more frequently than the other assays. In conclusion, the evaluated antibody tests showed a heterogeneity in their performances and only a few tests performed well with samples having low IFA IgG titers, an important aspect for diagnostics and epidemiological investigations.", "doi": "10.1038/s41598-021-87289-6", "pmid": "33828214", "labels": {"Type: Journal article": null, "Category: Other": null, "Funder: VR": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-87289-6"}], "notes": [], "created": "2021-04-09T16:40:58.037Z", "modified": "2021-09-28T13:28:38.352Z"}, {"entity": "publication", "iuid": "524d8edfc6a445d8af1393abeba6c868", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/524d8edfc6a445d8af1393abeba6c868.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/524d8edfc6a445d8af1393abeba6c868"}}, "title": "Uneven growth of SARS-CoV-2 clones evidenced by more than 500,000 whole-genome sequences", "authors": [{"family": "Zeng", "given": "Hong Li", "initials": "HL"}, {"family": "Liu", "given": "Yue", "initials": "Y"}, {"family": "Thorell", "given": "Kaisa", "initials": "K"}, {"family": "Norden", "given": "Rickard", "initials": "R"}, {"family": "Aurell", "given": "Erik", "initials": "E"}], "type": "posted-content", "published": "2021-04-06", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.06.437914", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Genomics & transcriptomics": null}, "xrefs": [], "notes": [], "created": "2021-04-08T18:32:33.788Z", "modified": "2021-04-13T14:01:53.008Z"}, {"entity": "publication", "iuid": "53ae2f2924db4176962ce29761d86697", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53ae2f2924db4176962ce29761d86697.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53ae2f2924db4176962ce29761d86697"}}, "title": "The Up state of the SARS-COV-2 Spike homotrimer favors an increased virulence for new variants", "authors": [{"family": "Giron", "given": "Carolina Corr\u00eaa", "initials": "CC"}, {"family": "Laaksonen", "given": "Aatto", "initials": "A"}, {"family": "da Silva", "given": "Fernando Lu\u00eds Barroso", "initials": "FLB"}], "type": "posted-content", "published": "2021-04-06", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.05.438465", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-08T18:35:24.719Z", "modified": "2021-04-15T18:28:09.307Z"}, {"entity": "publication", "iuid": "a1911234966d4ac7babf41bc2fbfb0b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a1911234966d4ac7babf41bc2fbfb0b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a1911234966d4ac7babf41bc2fbfb0b0"}}, "title": "The Other Side of SARS-CoV-2 Infection: Neurological Sequelae in Patients.", "authors": [{"family": "Alonso-Bellido", "given": "Isabel M", "initials": "IM"}, {"family": "Bachiller", "given": "Sara", "initials": "S"}, {"family": "V\u00e1zquez", "given": "Guillermo", "initials": "G"}, {"family": "Cruz-Hern\u00e1ndez", "given": "Luis", "initials": "L"}, {"family": "Mart\u00ednez", "given": "Emilio", "initials": "E"}, {"family": "Ruiz-Mateos", "given": "Ezequiel", "initials": "E"}, {"family": "Deierborg", "given": "Tomas", "initials": "T"}, {"family": "Venero", "given": "Jos\u00e9 L", "initials": "JL"}, {"family": "Real", "given": "Luis M", "initials": "LM"}, {"family": "Ruiz", "given": "Roc\u00edo", "initials": "R"}], "type": "journal article", "published": "2021-04-06", "journal": {"title": "Front Aging Neurosci", "issn": "1663-4365", "issn-l": null, "volume": "13", "issue": null, "pages": "632673"}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the globe causing coronavirus disease 2019 (COVID-19). Because it affects the respiratory system, common symptoms are cough and breathing difficulties with fever and fatigue. Also, some cases progress to acute respiratory distress syndrome (ARDS). The acute phase of COVID-19 has been also related to nervous system symptoms, including loss of taste and smell as well as encephalitis and cerebrovascular disorders. However, it remains unclear if neurological complications are due to the direct viral infection of the nervous system, or they appear as a consequence of the immune reaction against the virus in patients who presented pre-existing deficits or had a certain detrimental immune response. Importantly, the medium and long-term consequences of the infection by SARS-CoV-2 in the nervous system remain at present unknown. This review article aims to give an overview of the current neurological symptoms associated with COVID-19, as well as attempting to provide an insight beyond the acute affectation.", "doi": "10.3389/fnagi.2021.632673", "pmid": "33889082", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8055831"}], "notes": [], "created": "2021-04-29T16:10:40.146Z", "modified": "2021-04-29T16:11:31.138Z"}, {"entity": "publication", "iuid": "5898be945cfd4aea99cd1a994bb2ba1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5898be945cfd4aea99cd1a994bb2ba1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5898be945cfd4aea99cd1a994bb2ba1d"}}, "title": "Perceived Effectiveness, Restrictiveness, and Compliance with Containment Measures against the Covid-19 Pandemic: An International Comparative Study in 11 Countries", "authors": [{"family": "Georgieva", "given": "Irina", "initials": "I"}, {"family": "Lantta", "given": "Tella", "initials": "T"}, {"family": "Lickiewicz", "given": "Jakub", "initials": "J"}, {"family": "Pekara", "given": "Jaroslav", "initials": "J"}, {"family": "Wikman", "given": "Sofia", "initials": "S"}, {"family": "Losevi\u010da", "given": "Marina", "initials": "M"}, {"family": "Raveesh", "given": "Bevinahalli", "initials": "B"}, {"family": "Mihai", "given": "Adriana", "initials": "A"}, {"family": "Lepping", "given": "Peter", "initials": "P"}], "type": "journal-article", "published": "2021-04-06", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "7", "pages": "3806"}, "abstract": "National governments took action to delay the transmission of the coronavirus (SARS-CoV-2) by implementing different containment measures. We developed an online survey that included 44 different containment measures. We aimed to assess how effective citizens perceive these measures, which measures are perceived as violation of citizens' personal freedoms, which opinions and demographic factors have an effect on compliance with the measures, and what governments can do to most effectively improve citizens' compliance. The survey was disseminated in 11 countries: UK, Belgium, Netherlands, Bulgaria, Czech Republic, Finland, India, Latvia, Poland, Romania, and Sweden. We acquired 9543 unique responses. Our findings show significant differences across countries in perceived effectiveness, restrictiveness, and compliance. Governments that suffer low levels of trust should put more effort into persuading citizens, especially men, in the effectiveness of the proposed measures. They should provide financial compensation to citizens who have lost their job or income due to the containment measures to improve measure compliance. Policymakers should implement the least restrictive and most effective public health measures first during pandemic emergencies instead of implementing a combination of many restrictive measures, which has the opposite effect on citizens' adherence and undermines human rights.", "doi": "10.3390/ijerph18073806", "pmid": "33917334", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-04-27T15:00:06.043Z", "modified": "2021-06-18T15:51:54.429Z"}, {"entity": "publication", "iuid": "f76c3e11e2094a3db5ca89e4e76dac36", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f76c3e11e2094a3db5ca89e4e76dac36.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f76c3e11e2094a3db5ca89e4e76dac36"}}, "title": "Heparin binding protein in severe COVID-19-A prospective observational cohort study.", "authors": [{"family": "Mellhammar", "given": "Lisa", "initials": "L"}, {"family": "Thelaus", "given": "Louise", "initials": "L"}, {"family": "El\u00e9n", "given": "Sixten", "initials": "S"}, {"family": "Fisher", "given": "Jane", "initials": "J"}, {"family": "Linder", "given": "Adam", "initials": "A"}], "type": "journal article", "published": "2021-04-06", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "4", "pages": "e0249570", "issn-l": "1932-6203"}, "abstract": "Neutrophil-derived heparin binding protein (HBP; also known as azurocidin or CAP-37) is a key player in bacterial sepsis and a promising biomarker in severe infections. The aims of this study were to assess whether HBP is involved in the pathophysiology of COVID-19 and, if so, whether it can be used to predict severe disease preferably using a point-of-care test.\n\nThis was a prospective convenience sample study of biomarkers in patients admitted to Sk\u00e5ne University hospital in Sweden with a confirmed COVID-19 diagnosis. Plasma samples and clinical data were collected within 72h after admission, during hospital stay and at discharge. Plasma HBP concentrations samples were measured both with enzyme-linked immunosorbent assay (ELISA) and with a novel dry immunofluorescence analyzer (Joinstar) point-of-care test.\n\nThirty-five COVID-19 patients were enrolled in the study. Twenty-nine patients had blood samples taken within 72h after admission. We compared the highest HBP value taken within 72h after admission in patients who eventually developed organ dysfunction (n = 23) compared to those who did not (n = 6), and found that HBP was significantly elevated in those who developed organ dysfunction (25.0 ng/mL (interquartile range (IQR) 16.6-48.5) vs 10.6 ng/mL (IQR 4.8-21.7 ng/mL), p = 0.03). Point-of-care test measurements correlated well with ELISA measurements (R = 0.83). HBP measured by the POC device predicted development of COVID-induced organ dysfunction with an AUC of 0.88 (95% confidence interval (CI) 0.70-1.0).\n\nHBP is elevated prior to onset of organ dysfunction in patients with severe COVID-19 using a newly developed point-of-care test and hence HBP could be used in a clinical setting as a prognostic marker in COVID-19.", "doi": "10.1371/journal.pone.0249570", "pmid": "33822821", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-37580"}], "notes": [], "created": "2021-04-07T10:07:36.447Z", "modified": "2021-04-07T10:12:19.156Z"}, {"entity": "publication", "iuid": "45fc1c11b1b34a8590421d35f7cab87a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/45fc1c11b1b34a8590421d35f7cab87a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/45fc1c11b1b34a8590421d35f7cab87a"}}, "title": "Face mask use during the Covid-19 pandemic - the significance of culture and the symbolic meaning of behaviour.", "authors": [{"family": "Timpka", "given": "Toomas", "initials": "T"}, {"family": "Nyce", "given": "James M", "initials": "JM"}], "type": "journal article", "published": "2021-04-06", "journal": {"title": "Ann Epidemiol", "issn": "1873-2585", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "During public emergencies, a door can open on the fundamental elements upon which a society's social order is built. The Covid-19 pandemic has opened such a door in societies worldwide. We outline in this commentary some of these social elements and how they may have influenced face mask use during the early stages of the pandemic. The purpose is to expand the perspective on mechanisms that are relevant to consider in pandemic response planning. Our look at these fundamental elements showed that latent aspects of the dominant culture and various symbolic meanings of behaviours can reduce adherence with public health recommendations if they are overlooked in the strategic health plans. We conclude that when policymakers decide non-pharmacological interventions during pandemics, they should take into account fundamental attitudes and beliefs that may influence population behaviour. This will require paying attention to variations in things like culture and symbolic meanings of behaviour.", "doi": "10.1016/j.annepidem.2021.03.012", "pmid": "33836290", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S1047-2797(21)00056-9"}], "notes": [], "created": "2021-04-12T16:12:11.271Z", "modified": "2022-11-23T09:01:18.488Z"}, {"entity": "publication", "iuid": "4cf20ca7e7dd4720962ed406c5e2c909", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4cf20ca7e7dd4720962ed406c5e2c909.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4cf20ca7e7dd4720962ed406c5e2c909"}}, "title": "In Silico Mining of Terpenes from Red-Sea Invertebrates for SARS-CoV-2 Main Protease (M pro) Inhibitors.", "authors": [{"family": "Ibrahim", "given": "Mahmoud A A", "initials": "MAA"}, {"family": "Abdelrahman", "given": "Alaa H M", "initials": "AHM"}, {"family": "Mohamed", "given": "Tarik A", "initials": "TA"}, {"family": "Atia", "given": "Mohamed A M", "initials": "MAM"}, {"family": "Al-Hammady", "given": "Montaser A M", "initials": "MAM"}, {"family": "Abdeljawaad", "given": "Khlood A A", "initials": "KAA"}, {"family": "Elkady", "given": "Eman M", "initials": "EM"}, {"family": "Moustafa", "given": "Mahmoud F", "initials": "MF"}, {"family": "Alrumaihi", "given": "Faris", "initials": "F"}, {"family": "Allemailem", "given": "Khaled S", "initials": "KS"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}, {"family": "Par\u00e9", "given": "Paul W", "initials": "PW"}, {"family": "Efferth", "given": "Thomas", "initials": "T"}, {"family": "Hegazy", "given": "Mohamed-Elamir F", "initials": "MF"}], "type": "journal article", "published": "2021-04-05", "journal": {"title": "Molecules", "issn": "1420-3049", "volume": "26", "issue": "7", "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for the COVID-19 pandemic, which generated more than 1.82 million deaths in 2020 alone, in addition to 83.8 million infections. Currently, there is no antiviral medication to treat COVID-19. In the search for drug leads, marine-derived metabolites are reported here as prospective SARS-CoV-2 inhibitors. Two hundred and twenty-seven terpene natural products isolated from the biodiverse Red-Sea ecosystem were screened for inhibitor activity against the SARS-CoV-2 main protease (M pro) using molecular docking and molecular dynamics (MD) simulations combined with molecular mechanics/generalized Born surface area binding energy calculations. On the basis of in silico analyses, six terpenes demonstrated high potency as Mpro inhibitors with \u0394Gbinding \u2264 -40.0 kcal/mol. The stability and binding affinity of the most potent metabolite, erylosides B, were compared to the human immunodeficiency virus protease inhibitor, lopinavir. Erylosides B showed greater binding affinity towards SARS-CoV-2 Mpro than lopinavir over 100 ns with \u0394Gbinding values of -51.9 vs. -33.6 kcal/mol, respectively. Protein-protein interactions indicate that erylosides B biochemical signaling shares gene components that mediate severe acute respiratory syndrome diseases, including the cytokine- and immune-signaling components BCL2L1, IL2, and PRKC. Pathway enrichment analysis and Boolean network modeling were performed towards a deep dissection and mining of the erylosides B target-function interactions. The current study identifies erylosides B as a promising anti-COVID-19 drug lead that warrants further in vitro and in vivo testing.", "doi": "10.3390/molecules26072082", "pmid": "33916461", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "molecules26072082"}, {"db": "pmc", "key": "PMC8038614"}, {"db": "NCBI", "key": "NC_045512.2", "description": "Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, complete genome"}], "notes": [], "created": "2021-05-04T16:27:49.783Z", "modified": "2021-11-18T09:05:18.572Z"}, {"entity": "publication", "iuid": "317a13989d5e43c78a5e660bf9a2adb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/317a13989d5e43c78a5e660bf9a2adb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/317a13989d5e43c78a5e660bf9a2adb1"}}, "title": "Implementation of the COVID-19 Vulnerability Index Across an International Network of Health Care Data Sets: Collaborative External Validation Study.", "authors": [{"family": "Reps", "given": "Jenna M", "initials": "JM", "orcid": "0000-0002-2970-0778", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/135caa88779346ac97e682edad7b6805.json"}}, {"family": "Kim", "given": "Chungsoo", "initials": "C", "orcid": "0000-0003-1802-1777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19d957a32f3a4830b7e5937eb17ab595.json"}}, {"family": "Williams", "given": "Ross D", "initials": "RD", "orcid": "0000-0001-7723-417X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0392fa0097654386b5afb53621736a2b.json"}}, {"family": "Markus", "given": "Aniek F", "initials": "AF", "orcid": "0000-0001-5779-4794", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9266586bbfd54362bd837362d99e6f98.json"}}, {"family": "Yang", "given": "Cynthia", "initials": "C", "orcid": "0000-0001-6769-3153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1492941467c846b8a87f70a8f007de80.json"}}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T", "orcid": "0000-0002-8274-0357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11fd8deb257445e7a93a0a3098b246df.json"}}, {"family": "Falconer", "given": "Thomas", "initials": "T", "orcid": "0000-0001-6904-1394", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39f9b217653b4b3d8ad2b4ce30d1ca80.json"}}, {"family": "Jonnagaddala", "given": "Jitendra", "initials": "J", "orcid": "0000-0002-9912-2344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8403290b9ec43fe93b558de97d84559.json"}}, {"family": "Williams", "given": "Andrew", "initials": "A", "orcid": "0000-0002-0692-412X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/287d6018570d44588277109d7fb7e705.json"}}, {"family": "Fern\u00e1ndez-Bertol\u00edn", "given": "Sergio", "initials": "S", "orcid": "0000-0002-0029-6564", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d21eaa376144a42be9422fb45441fb4.json"}}, {"family": "DuVall", "given": "Scott L", "initials": "SL", "orcid": "0000-0002-4898-3865", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd524264c46548cf861123d43d57151a.json"}}, {"family": "Kostka", "given": "Kristin", "initials": "K", "orcid": "0000-0003-2595-8736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9675cf1b775341f6a3521c7dde950262.json"}}, {"family": "Rao", "given": "Gowtham", "initials": "G", "orcid": "0000-0002-4949-7236", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2ed658710d4a5eb53b4b0da495b6b4.json"}}, {"family": "Shoaibi", "given": "Azza", "initials": "A", "orcid": "0000-0002-6976-2594", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58deef993a4e4e008923f454d8617b61.json"}}, {"family": "Ostropolets", "given": "Anna", "initials": "A", "orcid": "0000-0002-0847-6682", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f642e577d2445a3a7ce873b42d0c479.json"}}, {"family": "Spotnitz", "given": "Matthew E", "initials": "ME", "orcid": "0000-0003-2869-0237", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d85f7c654b554b66b57eea3c47b33468.json"}}, {"family": "Zhang", "given": "Lin", "initials": "L", "orcid": "0000-0002-2064-8440", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b787b06f236743559ac8b09000d66ace.json"}}, {"family": "Casajust", "given": "Paula", "initials": "P", "orcid": "0000-0003-2733-5436", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8a3feb959bd461c8c4ad81fcd9dee8b.json"}}, {"family": "Steyerberg", "given": "Ewout W", "initials": "EW", "orcid": "0000-0002-7787-0122", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f248f68b4e144348a1969407863dadb8.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Kaas-Hansen", "given": "Benjamin Skov", "initials": "BS", "orcid": "0000-0003-1023-0371", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2365fe9468204435b0bb04abc7edface.json"}}, {"family": "Choi", "given": "Young Hwa", "initials": "YH", "orcid": "0000-0001-5254-3101", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e99fc02a7e45f197e6d745bb214e9c.json"}}, {"family": "Morales", "given": "Daniel", "initials": "D", "orcid": "0000-0002-0063-8069", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2db57e8786f41168f4a59dcab7086c3.json"}}, {"family": "Liaw", "given": "Siaw-Teng", "initials": "ST", "orcid": "0000-0001-5989-3614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aacd21dc33904474aa9239d5da644a84.json"}}, {"family": "Abrah\u00e3o", "given": "Maria Tereza Fernandes", "initials": "MTF", "orcid": "0000-0003-2701-670X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/725376c88fe14c138abace2cb37170b4.json"}}, {"family": "Areia", "given": "Carlos", "initials": "C", "orcid": "0000-0002-4668-7069", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7232f54be5df43f0b984d0117d88a054.json"}}, {"family": "Matheny", "given": "Michael E", "initials": "ME", "orcid": "0000-0003-3217-4147", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75cbaa15413a4673ae9037f58cc9a314.json"}}, {"family": "Lynch", "given": "Kristine E", "initials": "KE", "orcid": "0000-0002-2221-2421", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fdab158b00984381b1379ab876c1e09f.json"}}, {"family": "Arag\u00f3n", "given": "Mar\u00eda", "initials": "M", "orcid": "0000-0002-5990-6953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7030a55a3e84c36ad06f405dc1f9d68.json"}}, {"family": "Park", "given": "Rae Woong", "initials": "RW", "orcid": "0000-0003-4989-3287", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8974a9e22f940d7939f0bec7810c9c6.json"}}, {"family": "Hripcsak", "given": "George", "initials": "G", "orcid": "0000-0003-2664-7614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93e21b1266964d22b49cdafdd03caa7d.json"}}, {"family": "Reich", "given": "Christian G", "initials": "CG", "orcid": "0000-0002-3641-055X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6982fa4f228643c6bac91609a0b336d3.json"}}, {"family": "Suchard", "given": "Marc A", "initials": "MA", "orcid": "0000-0001-9818-479X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f920e0e55c94e91b4dcff796bd24246.json"}}, {"family": "You", "given": "Seng Chan", "initials": "SC", "orcid": "0000-0002-5052-6399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4be7ad3cc7c6440b9f628d7bcedc8a6a.json"}}, {"family": "Ryan", "given": "Patrick B", "initials": "PB", "orcid": "0000-0002-9727-2138", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7f5f6d8b6bb4d85b1430cda6aea55b8.json"}}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D", "orcid": "0000-0002-3950-6346", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1c3f99e11244a3b90ba881356d3e259.json"}}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR", "orcid": "0000-0003-0621-1979", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d03ea51cfd6344d5a6469fef31e9f941.json"}}], "type": "journal article", "published": "2021-04-05", "journal": {"title": "JMIR Med Inform", "issn": "2291-9694", "issn-l": null, "volume": "9", "issue": "4", "pages": "e21547"}, "abstract": "SARS-CoV-2 is straining health care systems globally. The burden on hospitals during the pandemic could be reduced by implementing prediction models that can discriminate patients who require hospitalization from those who do not. The COVID-19 vulnerability (C-19) index, a model that predicts which patients will be admitted to hospital for treatment of pneumonia or pneumonia proxies, has been developed and proposed as a valuable tool for decision-making during the pandemic. However, the model is at high risk of bias according to the \"prediction model risk of bias assessment\" criteria, and it has not been externally validated.\n\nThe aim of this study was to externally validate the C-19 index across a range of health care settings to determine how well it broadly predicts hospitalization due to pneumonia in COVID-19 cases.\n\nWe followed the Observational Health Data Sciences and Informatics (OHDSI) framework for external validation to assess the reliability of the C-19 index. We evaluated the model on two different target populations, 41,381 patients who presented with SARS-CoV-2 at an outpatient or emergency department visit and 9,429,285 patients who presented with influenza or related symptoms during an outpatient or emergency department visit, to predict their risk of hospitalization with pneumonia during the following 0-30 days. In total, we validated the model across a network of 14 databases spanning the United States, Europe, Australia, and Asia.\n\nThe internal validation performance of the C-19 index had a C statistic of 0.73, and the calibration was not reported by the authors. When we externally validated it by transporting it to SARS-CoV-2 data, the model obtained C statistics of 0.36, 0.53 (0.473-0.584) and 0.56 (0.488-0.636) on Spanish, US, and South Korean data sets, respectively. The calibration was poor, with the model underestimating risk. When validated on 12 data sets containing influenza patients across the OHDSI network, the C statistics ranged between 0.40 and 0.68.\n\nOur results show that the discriminative performance of the C-19 index model is low for influenza cohorts and even worse among patients with COVID-19 in the United States, Spain, and South Korea. These results suggest that C-19 should not be used to aid decision-making during the COVID-19 pandemic. Our findings highlight the importance of performing external validation across a range of settings, especially when a prediction model is being extrapolated to a different population. In the field of prediction, extensive validation is required to create appropriate trust in a model.", "doi": "10.2196/21547", "pmid": "33661754", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8023380"}, {"db": "pii", "key": "v9i4e21547"}], "notes": [], "created": "2021-11-15T06:53:48.925Z", "modified": "2023-06-19T15:02:21.240Z"}, {"entity": "publication", "iuid": "42c6f5159867443ba26ed8b54fdc4294", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/42c6f5159867443ba26ed8b54fdc4294.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/42c6f5159867443ba26ed8b54fdc4294"}}, "title": "Driving potent neutralization of a SARS-CoV-2 Variant of Concern with a heterotypic boost", "authors": [{"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Mandolesi", "given": "Marco", "initials": "M"}, {"family": "Kim", "given": "Changil", "initials": "C"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Vidakovics", "given": "Laura Perez", "initials": "LP"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Hedestam", "given": "Gunilla B Karlsson", "initials": "GBK"}, {"family": "Murrell", "given": "Ben", "initials": "B"}], "type": "posted-content", "published": "2021-04-05", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.03.438330", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Funder: H2020": null, "Funder: VR": null}, "xrefs": [{"db": "URL", "key": "https://github.com/MurrellGroup/VOCfreq", "description": "code to complete analyses and instructions to acquire data"}], "notes": [], "created": "2021-04-08T18:37:21.184Z", "modified": "2021-11-18T11:58:02.091Z"}, {"entity": "publication", "iuid": "513b358e6a614996b03261079249c2d6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/513b358e6a614996b03261079249c2d6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/513b358e6a614996b03261079249c2d6"}}, "title": "COVID-19 vaccination in mastocytosis: recommendations of the European Competence Network on Mastocytosis (ECNM) and American Initiative in Mast Cell Diseases (AIM).", "authors": [{"family": "Bonadonna", "given": "Patrizia", "initials": "P"}, {"family": "Brockow", "given": "Knut", "initials": "K"}, {"family": "Niedoszytko", "given": "Marek", "initials": "M"}, {"family": "Elberink", "given": "Hanneke Oude", "initials": "HO"}, {"family": "Akin", "given": "Cem", "initials": "C"}, {"family": "Nedoszytko", "given": "Boguslaw", "initials": "B"}, {"family": "Butterfield", "given": "Joseph H", "initials": "JH"}, {"family": "Alvarez-Twose", "given": "Ivan", "initials": "I"}, {"family": "Sotlar", "given": "Karl", "initials": "K"}, {"family": "Schwaab", "given": "Juliana", "initials": "J"}, {"family": "Jawhar", "given": "Mohamad", "initials": "M"}, {"family": "Castells", "given": "Mariana", "initials": "M"}, {"family": "Sperr", "given": "Wolfgang R", "initials": "WR"}, {"family": "Hermine", "given": "Olivier", "initials": "O"}, {"family": "Gotlib", "given": "Jason", "initials": "J"}, {"family": "Zanotti", "given": "Roberta", "initials": "R"}, {"family": "Reiter", "given": "Andreas", "initials": "A"}, {"family": "Broesby-Olsen", "given": "Sigurd", "initials": "S"}, {"family": "Bindslev-Jensen", "given": "Carsten", "initials": "C"}, {"family": "Schwartz", "given": "Lawrence B", "initials": "LB"}, {"family": "Horny", "given": "Hans-Peter", "initials": "HP"}, {"family": "Radia", "given": "Deepti", "initials": "D"}, {"family": "Triggiani", "given": "Massimo", "initials": "M"}, {"family": "Sabato", "given": "Vito", "initials": "V"}, {"family": "Carter", "given": "Melody C", "initials": "MC"}, {"family": "Siebenhaar", "given": "Frank", "initials": "F"}, {"family": "Orfao", "given": "Alberto", "initials": "A"}, {"family": "Grattan", "given": "Clive", "initials": "C"}, {"family": "Metcalfe", "given": "Dean D", "initials": "DD"}, {"family": "Arock", "given": "Michel", "initials": "M"}, {"family": "Gulen", "given": "Theo", "initials": "T"}, {"family": "Hartmann", "given": "Karin", "initials": "K"}, {"family": "Valent", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2021-04-05", "journal": {"title": "J Allergy Clin Immunol Pract", "issn": "2213-2201", "volume": null, "issue": null, "issn-l": null}, "abstract": "Mastocytosis is a neoplasm characterized by an accumulation of mast cells in various organs and increased risk for severe anaphylaxis in patients with concomitant allergies. Covid-19 is a pandemic that is associated with a relatively high rate of severe lung disease and mortality. The mortality is particularly high in those with certain comorbidities and increases with age. Recently, several companies have developed an effective vaccination against Covid-19. Although the reported frequency of severe side effects is low, there is an emerging discussion about the safety of Covid-19 vaccination in patients with severe allergies and mastocytosis. However, even in these patients, severe adverse reactions are rare. We therefore recommend the broad use of Covid-19 vaccination in patients with mastocytosis on a global basis. The only well-established exception is a known or suspected allergy against a constituent of the vaccine. Safety measures, including premedication and post-vaccination observation should be considered in all patients with mastocytosis, depending on the individual personal risk and overall situation in each case. The current article provides a summary of published data, observations and expert opinion that form the basis of these recommendations.", "doi": "10.1016/j.jaip.2021.03.041", "pmid": "33831618", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2213-2198(21)00386-X"}], "notes": [], "created": "2021-04-09T16:46:32.560Z", "modified": "2021-04-23T16:05:54.583Z"}, {"entity": "publication", "iuid": "cec71ba523f3439d9f438153be347ae4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cec71ba523f3439d9f438153be347ae4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cec71ba523f3439d9f438153be347ae4"}}, "title": "COVID-19 research priorities for non-pharmaceutical public health and social measures.", "authors": [{"family": "Semenza", "given": "Jan C", "initials": "JC"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Baka", "given": "Agoritsa", "initials": "A"}, {"family": "Broberg", "given": "Eeva", "initials": "E"}, {"family": "Cenciarelli", "given": "Orlando", "initials": "O"}, {"family": "De Angelis", "given": "Stefania", "initials": "S"}, {"family": "Einoder-Moreno", "given": "Margot", "initials": "M"}, {"family": "Dalmau", "given": "Irina Jovel Quinonez", "initials": "IJQ"}, {"family": "Kinross", "given": "Pete", "initials": "P"}, {"family": "Kinsman", "given": "John", "initials": "J"}, {"family": "Leitmeyer", "given": "Katrin", "initials": "K"}, {"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "Needham", "given": "Howard", "initials": "H"}, {"family": "Plachouras", "given": "Diamantis", "initials": "D"}, {"family": "Robesyn", "given": "Emmanuel", "initials": "E"}, {"family": "Rosales-Klintz", "given": "Senia", "initials": "S"}, {"family": "Suk", "given": "Jonathan E", "initials": "JE"}, {"family": "Suetens", "given": "Carl", "initials": "C"}, {"family": "Weist", "given": "Klaus", "initials": "K"}, {"family": "W\u00fcrz", "given": "Andrea", "initials": "A"}, {"family": "Penttinen", "given": "Pasi", "initials": "P"}], "type": "journal article", "published": "2021-04-05", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": null, "issue": null, "pages": "1-12", "issn-l": null}, "abstract": null, "doi": "10.1017/S0950268821000716", "pmid": "33818348", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0950268821000716"}], "notes": [], "created": "2021-04-06T10:04:18.839Z", "modified": "2021-04-06T10:04:18.848Z"}, {"entity": "publication", "iuid": "3c9d39c1019b430086cd725b0aff2ad5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3c9d39c1019b430086cd725b0aff2ad5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3c9d39c1019b430086cd725b0aff2ad5"}}, "title": "COVID-19: A novel burden on the fragile health system of Angola.", "authors": [{"family": "Gyeltshen", "given": "Dawa", "initials": "D"}, {"family": "Musa", "given": "Shuaibu Saidu", "initials": "SS"}, {"family": "Amesho", "given": "Josephine Ndapewoshali", "initials": "JN"}, {"family": "Ewelike", "given": "Samuel Chukwuebuka", "initials": "SC"}, {"family": "Bayoh", "given": "Alex Vandy Saffa", "initials": "AVS"}, {"family": "Al-Sammour", "given": "Christophe", "initials": "C"}, {"family": "Camua", "given": "Angel Anthony", "initials": "AA"}, {"family": "Lin", "given": "Xu", "initials": "X"}, {"family": "Lowe", "given": "Mat", "initials": "M"}, {"family": "Ahmadi", "given": "Attaullah", "initials": "A"}, {"family": "Ntacyabukura", "given": "Blaise", "initials": "B"}, {"family": "Adebisi", "given": "Yusuff Adebayo", "initials": "YA"}, {"family": "Lucero-Prisno", "given": "Don Eliseo", "initials": "DE"}], "type": "journal article", "published": "2021-04-03", "journal": {"title": "J Glob Health", "issn": "2047-2986", "volume": "11", "issue": null, "pages": "03059", "issn-l": "2047-2978"}, "abstract": null, "doi": "10.7189/jogh.11.03059", "pmid": "33828839", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jogh-11-03059"}, {"db": "pmc", "key": "PMC8021071"}], "notes": [], "created": "2021-04-09T16:43:53.499Z", "modified": "2021-04-09T16:44:17.395Z"}, {"entity": "publication", "iuid": "d8ee3c70a18b4950b58b8cc0d0a44279", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d8ee3c70a18b4950b58b8cc0d0a44279.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d8ee3c70a18b4950b58b8cc0d0a44279"}}, "title": "COVID-19 in solid organ transplant recipients: A national cohort study from Sweden.", "authors": [{"family": "S\u00f8fteland", "given": "John Mackay", "initials": "JM"}, {"family": "Friman", "given": "Gustav", "initials": "G"}, {"family": "von Zur-M\u00fchlen", "given": "Bengt", "initials": "B"}, {"family": "Ericzon", "given": "Bo-G\u00f6ran", "initials": "B"}, {"family": "Wallquist", "given": "Carin", "initials": "C"}, {"family": "Karason", "given": "Kristjan", "initials": "K"}, {"family": "Friman", "given": "Vanda", "initials": "V"}, {"family": "Ekelund", "given": "Jan", "initials": "J"}, {"family": "Felldin", "given": "Marie", "initials": "M"}, {"family": "Magnusson", "given": "Jesper", "initials": "J"}, {"family": "Haugen L\u00f6fman", "given": "Ida", "initials": "I"}, {"family": "Schult", "given": "Andreas", "initials": "A"}, {"family": "de Coursey", "given": "Emily", "initials": "E"}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Jacobsson", "given": "Hanna", "initials": "H"}, {"family": "Liljeqvist", "given": "Jan-\u00c5ke", "initials": "J"}, {"family": "Biglarnia", "given": "Ali Reza", "initials": "AR"}, {"family": "Lindn\u00e9r", "given": "Per", "initials": "P"}, {"family": "Oltean", "given": "Mihai", "initials": "M"}], "type": "journal article", "published": "2021-04-03", "journal": {"title": "Am J Transplant", "issn": "1600-6143", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Solid organ transplant (SOT) recipients run a high risk for adverse outcomes from COVID-19, with reported mortality around 19%. We retrospectively reviewed all known Swedish SOT recipients with RT-PCR confirmed COVID-19 between March 1 st and November 20th, 2020 and analyzed patient characteristics, management, and outcome. We identified 230 patients with a median age of 54.0 years (13.2), who were predominantly male (64%). Most patients were hospitalized (64%), but 36% remained outpatients. Age >50 and male sex were among predictors of transition from outpatient to inpatient status. National early warning Score 2 (NEWS2) at presentation was higher in non-survivors. Thirty-day all-cause mortality was 9.6% (15.0% for inpatients), increased with age and BMI, and was higher in men. Renal function decreased during COVID-19 but recovered in most patients. SARS-CoV-2 antibodies were identified in 78% of patients at 1-2 months post-infection. Nucleocapsid-specific antibodies decreased to 38% after 6-7 months, while spike-specific antibody responses were more durable. Seroprevalence in 559 asymptomatic patients was 1.4%. Many patients can be managed on an outpatient basis aided by risk stratification with age, sex, and NEWS2 score. Factors associated with adverse outcomes include older age, male sex, greater BMI, and a higher NEWS2 score.", "doi": "10.1111/ajt.16596", "pmid": "33811777", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-06T10:13:30.721Z", "modified": "2021-04-06T10:13:53.666Z"}, {"entity": "publication", "iuid": "e2b438d13f5e46f5bf03be41bc5f6b15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2b438d13f5e46f5bf03be41bc5f6b15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2b438d13f5e46f5bf03be41bc5f6b15"}}, "title": "A mediating role for mental health in associations between COVID-19-related self-stigma, PTSD, quality of life, and insomnia among patients recovered from COVID-19.", "authors": [{"family": "Mahmoudi", "given": "Hosein", "initials": "H"}, {"family": "Saffari", "given": "Mohsen", "initials": "M"}, {"family": "Movahedi", "given": "Mahmoud", "initials": "M"}, {"family": "Sanaeinasab", "given": "Hormoz", "initials": "H"}, {"family": "Rashidi-Jahan", "given": "Hojat", "initials": "H"}, {"family": "Pourgholami", "given": "Morteza", "initials": "M"}, {"family": "Poorebrahim", "given": "Ali", "initials": "A"}, {"family": "Barshan", "given": "Jalal", "initials": "J"}, {"family": "Ghiami", "given": "Milad", "initials": "M"}, {"family": "Khoshmanesh", "given": "Saman", "initials": "S"}, {"family": "Potenza", "given": "Marc N", "initials": "MN"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-04-03", "journal": {"title": "Brain Behav", "issn": "2162-3279", "issn-l": null, "volume": null, "issue": null, "pages": "e02138"}, "abstract": "Patients with COVID-19 often suffer from psychological problems such as post-traumatic stress disorder (PTSD) and self-stigmatization that may negatively impact their quality of life and sleep. This study examined mental health as a potential mediating factor linking self-stigmatization and PTSD to quality of life and sleep.\r\n\r\nUsing a cross-sectional design, 844 people who had recovered from COVID-19 were called and interviewed. Data were collected using structured scales. Structural equation modeling was applied to assess fitness of a mediation model including self-stigma and PTSD as independent factors and quality of life and insomnia as dependent variables.\r\n\r\nMental health, COVID-19-related self-stigma, and mental quality of life were associated. Insomnia, PTSD, and COVID-19-related self-stigma displayed significant direct associations (r = .334 to 0.454; p < .01). A mediation model indicated satisfactory goodness of fit (CFI = 0.968, TLI = 0.950, SRMR = 0.071, RMSEA = 0.068). Mental health as a mediator had negative relationships with COVID-19-related self-stigma, PTSD, and insomnia and positive associations with quality of life.\r\n\r\nMental health may mediate effects of COVID-19-related self-stigma and PTSD on quality of life and insomnia. Designing programs to improve mental health among patients with COVID-19 may include efforts to reduce negative effects of PTSD and COVID-19-related self-stigma on quality of life and insomnia.", "doi": "10.1002/brb3.2138", "pmid": "33811451", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-04-06T10:14:42.317Z", "modified": "2021-06-18T15:50:55.477Z"}, {"entity": "publication", "iuid": "38fb2ecbee504f5b8f2376f0b9fee004", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38fb2ecbee504f5b8f2376f0b9fee004.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38fb2ecbee504f5b8f2376f0b9fee004"}}, "title": "Vaccines and Allergic reactions: the past, the current COVID-19 pandemic, and future perspectives.", "authors": [{"family": "Sampath", "given": "Vanitha", "initials": "V"}, {"family": "Rabinowitz", "given": "Grace", "initials": "G"}, {"family": "Shah", "given": "Mihir", "initials": "M"}, {"family": "Jain", "given": "Surabhi", "initials": "S"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}, {"family": "Jesenak", "given": "Milos", "initials": "M"}, {"family": "Rabin", "given": "Ronald", "initials": "R"}, {"family": "Vieths", "given": "Stefan", "initials": "S"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Akdis", "given": "M\u00fcbeccel", "initials": "M"}, {"family": "Barber", "given": "Domingo", "initials": "D"}, {"family": "Breiteneder", "given": "Heimo", "initials": "H"}, {"family": "Chinthrajah", "given": "Sharon", "initials": "S"}, {"family": "Chivato", "given": "Tomas", "initials": "T"}, {"family": "Collins", "given": "William", "initials": "W"}, {"family": "Eiwegger", "given": "Thomas", "initials": "T"}, {"family": "Fast", "given": "Katherine", "initials": "K"}, {"family": "Fokkens", "given": "Wytske", "initials": "W"}, {"family": "O'Hehir", "given": "Robyn E", "initials": "RE"}, {"family": "Ollert", "given": "Markus", "initials": "M"}, {"family": "O'Mahony", "given": "Liam", "initials": "L"}, {"family": "Palomares", "given": "Oscar", "initials": "O"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Riggioni", "given": "Carmen", "initials": "C"}, {"family": "Shamji", "given": "Mohamed H", "initials": "MH"}, {"family": "Sokolowska", "given": "Milena", "initials": "M"}, {"family": "Torres", "given": "Maria Jose", "initials": "MJ"}, {"family": "Traidl-Hoffmann", "given": "Claudia", "initials": "C"}, {"family": "van Zelm", "given": "Menno", "initials": "M"}, {"family": "Wang", "given": "De Yun", "initials": "Y"}, {"family": "Zhang", "given": "Luo", "initials": "L"}, {"family": "Akdis", "given": "CezmiA", "initials": "C"}, {"family": "Nadeau", "given": "Kari C", "initials": "KC"}], "type": "journal article", "published": "2021-04-02", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": null, "issue": null, "issn-l": "0105-4538"}, "abstract": "Vaccines are essential public health tools with a favorable safety profile and prophylactic effectiveness that have historically played significant roles in reducing infectious disease burden in populations, when the majority of individuals are vaccinated. The COVID-19 vaccines are expected to have similar positive impacts on health across the globe. While serious allergic reactions to vaccines are rare, their underlying mechanisms and implications for clinical management should be considered to provide individuals with the safest care possible. In this review, we provide an overview of different types of allergic adverse reactions that can potentially occur aftervaccination and individual vaccine components capable of causing the allergic adverse reactions. We present the incidence of allergic adverse reactions during clinical studies and through post-authorization and post-marketing surveillance and provide plausible causes of these reactions based on potential allergenic components present in several common vaccines. Additionally, we review implications for individual diagnosis and management and vaccine manufacturing overall. Finally, we suggest areas for future research.", "doi": "10.1111/all.14840", "pmid": "33811364", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-04-06T10:17:59.817Z", "modified": "2021-04-23T16:06:21.995Z"}, {"entity": "publication", "iuid": "e24ad035f5844436a6bb40be8e35a395", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e24ad035f5844436a6bb40be8e35a395.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e24ad035f5844436a6bb40be8e35a395"}}, "title": "Stealth Fluorescence Labeling for Live Microscopy Imaging of mRNA Delivery.", "authors": [{"family": "Baladi", "given": "Tom", "initials": "T"}, {"family": "Nilsson", "given": "Jesper R", "initials": "JR"}, {"family": "Gallud", "given": "Audrey", "initials": "A"}, {"family": "Celauro", "given": "Emanuele", "initials": "E"}, {"family": "Gasse", "given": "C\u00e9cile", "initials": "C"}, {"family": "Levi-Acobas", "given": "Fabienne", "initials": "F"}, {"family": "Sarac", "given": "Ivo", "initials": "I"}, {"family": "Hollenstein", "given": "Marcel R", "initials": "MR"}, {"family": "Dahl\u00e9n", "given": "Anders", "initials": "A"}, {"family": "Esbj\u00f6rner", "given": "Elin K", "initials": "EK"}, {"family": "Wilhelmsson", "given": "L Marcus", "initials": "LM"}], "type": "journal article", "published": "2021-04-02", "journal": {"title": "J Am Chem Soc", "issn": "1520-5126", "volume": null, "issue": null, "issn-l": null}, "abstract": "Methods for tracking RNA inside living cells without perturbing their natural interactions and functions are critical within biology and, in particular, to facilitate studies of therapeutic RNA delivery. We present a stealth labeling approach that can efficiently, and with high fidelity, generate RNA transcripts, through enzymatic incorporation of the triphosphate of tC O, a fluorescent tricyclic cytosine analogue. We demonstrate this by incorporation of tCO in up to 100% of the natural cytosine positions of a 1.2 kb mRNA encoding for the histone H2B fused to GFP (H2B:GFP). Spectroscopic characterization of this mRNA shows that the incorporation rate of tCO is similar to cytosine, which allows for efficient labeling and controlled tuning of labeling ratios for different applications. Using live cell confocal microscopy and flow cytometry, we show that the tCO-labeled mRNA is efficiently translated into H2B:GFP inside human cells. Hence, we not only develop the use of fluorescent base analogue labeling of nucleic acids in live-cell microscopy but also, importantly, show that the resulting transcript is translated into the correct protein. Moreover, the spectral properties of our transcripts and their translation product allow for their straightforward, simultaneous visualization in live cells. Finally, we find that chemically transfected tCO-labeled RNA, unlike a state-of-the-art fluorescently labeled RNA, gives rise to expression of a similar amount of protein as its natural counterpart, hence representing a methodology for studying natural, unperturbed processing of mRNA used in RNA therapeutics and in vaccines, like the ones developed against SARS-CoV-2.", "doi": "10.1021/jacs.1c00014", "pmid": "33797236", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-06T10:41:47.769Z", "modified": "2021-04-06T10:41:47.794Z"}, {"entity": "publication", "iuid": "cda6c30f70f24141b31a4e3611da36b6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cda6c30f70f24141b31a4e3611da36b6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cda6c30f70f24141b31a4e3611da36b6"}}, "title": "Management of anaphylaxis due to COVID-19 vaccines in the elderly.", "authors": [{"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Blain", "given": "Hubert", "initials": "H"}, {"family": "Jutel", "given": "Marek", "initials": "M"}, {"family": "Ventura", "given": "Maria Teresa", "initials": "MT"}, {"family": "Worm", "given": "Margitta", "initials": "M"}, {"family": "Del Giacco", "given": "Stefano", "initials": "S"}, {"family": "Benetos", "given": "Athanasios", "initials": "A"}, {"family": "Bilo", "given": "M Beatrice", "initials": "MB"}, {"family": "Czarlewski", "given": "Wienczyslawa", "initials": "W"}, {"family": "Abdul Latiff", "given": "Amir Hamzah", "initials": "AH"}, {"family": "Al-Ahmad", "given": "Mona", "initials": "M"}, {"family": "Angier", "given": "Elizabeth", "initials": "E"}, {"family": "Annesi-Maesano", "given": "Isabella", "initials": "I"}, {"family": "Atanaskovic-Markovic", "given": "Marina", "initials": "M"}, {"family": "Bachert", "given": "Claus", "initials": "C"}, {"family": "Barbaud", "given": "Annick", "initials": "A"}, {"family": "Bedbrook", "given": "Anna", "initials": "A"}, {"family": "Bennoor", "given": "Kazi S", "initials": "KS"}, {"family": "Berghea", "given": "Elena Camelia", "initials": "EC"}, {"family": "Bindslev-Jensen", "given": "Carsten", "initials": "C"}, {"family": "Bonini", "given": "Sergio", "initials": "S"}, {"family": "Bosnic-Anticevich", "given": "Sinthia", "initials": "S"}, {"family": "Brockow", "given": "Knut", "initials": "K"}, {"family": "Brussino", "given": "Luisa", "initials": "L"}, {"family": "Camargos", "given": "Paulo", "initials": "P"}, {"family": "Canonica", "given": "G Walter", "initials": "GW"}, {"family": "Cardona", "given": "Victoria", "initials": "V"}, {"family": "Carreiro-Martins", "given": "Pedro", "initials": "P"}, {"family": "Carriazo", "given": "Ana", "initials": "A"}, {"family": "Casale", "given": "Thomas", "initials": "T"}, {"family": "Caubet", "given": "Jean-Christoph", "initials": "JC"}, {"family": "Cecchi", "given": "Lorenzo", "initials": "L"}, {"family": "Cherubini", "given": "Antonio", "initials": "A"}, {"family": "Christoff", "given": "George", "initials": "G"}, {"family": "Chu", "given": "Derek K", "initials": "DK"}, {"family": "Cruz", "given": "Alvaro A", "initials": "AA"}, {"family": "Dokic", "given": "Dejan", "initials": "D"}, {"family": "El-Gamal", "given": "Yehia", "initials": "Y"}, {"family": "Ebisawa", "given": "Motohiro", "initials": "M"}, {"family": "Eberlein", "given": "Bernadette", "initials": "B"}, {"family": "Farrell", "given": "John", "initials": "J"}, {"family": "Fernandez-Rivas", "given": "Montserrat", "initials": "M"}, {"family": "Fokkens", "given": "Wytske J", "initials": "WJ"}, {"family": "Fonseca", "given": "Joao A", "initials": "JA"}, {"family": "Gao", "given": "Yadong", "initials": "Y"}, {"family": "Gavazzi", "given": "Ga\u00ebtan", "initials": "G"}, {"family": "Gawlik", "given": "Radolslaw", "initials": "R"}, {"family": "Gelincik", "given": "Asli", "initials": "A"}, {"family": "Gemicio\u011flu", "given": "Bilun", "initials": "B"}, {"family": "Gotua", "given": "Maia", "initials": "M"}, {"family": "Gu\u00e9rin", "given": "Olivier", "initials": "O"}, {"family": "Haahtela", "given": "Tari", "initials": "T"}, {"family": "Hoffmann-Sommergruber", "given": "Karin", "initials": "K"}, {"family": "Hoffmann", "given": "Hans J\u00fcrgen", "initials": "HJ"}, {"family": "Hofmann", "given": "Maja", "initials": "M"}, {"family": "Hrubisko", "given": "Martin", "initials": "M"}, {"family": "lenaIllario", "given": "Madda", "initials": "M"}, {"family": "Irani", "given": "Carla", "initials": "C"}, {"family": "Ispayeva", "given": "Zhanat", "initials": "Z"}, {"family": "Ivancevich", "given": "Juan Carlos", "initials": "JC"}, {"family": "Julge", "given": "Kaja", "initials": "K"}, {"family": "Kaidashev", "given": "Igor", "initials": "I"}, {"family": "Khaitov", "given": "Musa", "initials": "M"}, {"family": "Knol", "given": "Edward", "initials": "E"}, {"family": "Kraxner", "given": "Helga", "initials": "H"}, {"family": "Kuna", "given": "Piotr", "initials": "P"}, {"family": "Kvedariene", "given": "Violeta", "initials": "V"}, {"family": "Lauerma", "given": "Antti", "initials": "A"}, {"family": "Le", "given": "Lan Tt", "initials": "LT"}, {"family": "Le Moing", "given": "Vincent", "initials": "V"}, {"family": "Levin", "given": "Michael", "initials": "M"}, {"family": "Louis", "given": "Renaud", "initials": "R"}, {"family": "Lourenco", "given": "Olga", "initials": "O"}, {"family": "Mahler", "given": "Vera", "initials": "V"}, {"family": "Martin", "given": "Finbarr C", "initials": "FC"}, {"family": "Matucci", "given": "Andrea", "initials": "A"}, {"family": "Milenkovic", "given": "Branislava", "initials": "B"}, {"family": "Miot", "given": "St\u00e9phanie", "initials": "S"}, {"family": "Montella", "given": "Emma", "initials": "E"}, {"family": "Morais-Almeida", "given": "Mario", "initials": "M"}, {"family": "Mortz", "given": "Charlotte G", "initials": "CG"}, {"family": "Mullol", "given": "Joaquim", "initials": "J"}, {"family": "Namazova-Baranova", "given": "Leyla", "initials": "L"}, {"family": "Neffen", "given": "Hugo", "initials": "H"}, {"family": "Nekam", "given": "Kristof", "initials": "K"}, {"family": "Niedoszytko", "given": "Marek", "initials": "M"}, {"family": "Odemyr", "given": "Mika\u00ebla", "initials": "M"}, {"family": "O'Hehir", "given": "Robyn E", "initials": "RE"}, {"family": "Okamoto", "given": "Yoshitaka", "initials": "Y"}, {"family": "Ollert", "given": "Markus", "initials": "M"}, {"family": "Palomares", "given": "Oscar", "initials": "O"}, {"family": "Papadopoulos", "given": "Nikolaos G", "initials": "NG"}, {"family": "Panzner", "given": "Petr", "initials": "P"}, {"family": "Passalacqua", "given": "Gianni", "initials": "G"}, {"family": "Patella", "given": "Vincenzo", "initials": "V"}, {"family": "Petrovic", "given": "Mirko", "initials": "M"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Pham-Thi", "given": "Nh\u00e2n", "initials": "N"}, {"family": "Plavec", "given": "Davor", "initials": "D"}, {"family": "Popov", "given": "Todor A", "initials": "TA"}, {"family": "Recto", "given": "Marysia T", "initials": "MT"}, {"family": "Regateiro", "given": "Frederico S", "initials": "FS"}, {"family": "Reynes", "given": "Jacques", "initials": "J"}, {"family": "Roller-Winsberger", "given": "Regina E", "initials": "RE"}, {"family": "Rolland", "given": "Yves", "initials": "Y"}, {"family": "Romano", "given": "Antonino", "initials": "A"}, {"family": "Rondon", "given": "Carmen", "initials": "C"}, {"family": "Rottem", "given": "Menachem", "initials": "M"}, {"family": "Rouadi", "given": "Philip W", "initials": "PW"}, {"family": "Salles", "given": "Nathalie", "initials": "N"}, {"family": "Samolinski", "given": "Boleslaw", "initials": "B"}, {"family": "Santos", "given": "Alexandra F", "initials": "AF"}, {"family": "Serpa", "given": "Faradiba Sarquis", "initials": "FS"}, {"family": "Sastre", "given": "Joaquin", "initials": "J"}, {"family": "Schols", "given": "Jos M G A", "initials": "JMGA"}, {"family": "Scichilone", "given": "Nicola", "initials": "N"}, {"family": "Sediva", "given": "Anna", "initials": "A"}, {"family": "Shamji", "given": "Mohamed H", "initials": "MH"}, {"family": "Sheikh", "given": "Aziz", "initials": "A"}, {"family": "Skypala", "given": "Isabel", "initials": "I"}, {"family": "Smolinska", "given": "Sylwia", "initials": "S"}, {"family": "Sokolowska", "given": "Milena", "initials": "M"}, {"family": "Sousa-Pinto", "given": "Bernardo", "initials": "B"}, {"family": "Sova", "given": "Milan", "initials": "M"}, {"family": "Stelmach", "given": "Rafael", "initials": "R"}, {"family": "Sturm", "given": "Gunter", "initials": "G"}, {"family": "Suppli Ulrik", "given": "Charlotte", "initials": "C"}, {"family": "Todo-Bom", "given": "Ana Maria", "initials": "AM"}, {"family": "Toppila-Salmi", "given": "Sanna", "initials": "S"}, {"family": "Tsiligianni", "given": "Ioanna", "initials": "I"}, {"family": "Torres", "given": "Maria", "initials": "M"}, {"family": "Untersmayr", "given": "Eva", "initials": "E"}, {"family": "Urrutia Pereira", "given": "Marilyn", "initials": "M"}, {"family": "Valiulis", "given": "Arunas", "initials": "A"}, {"family": "Vitte", "given": "Joana", "initials": "J"}, {"family": "Vultaggio", "given": "Alessandra", "initials": "A"}, {"family": "Wallace", "given": "Dana", "initials": "D"}, {"family": "Walusiak-Skorupa", "given": "Jolanta", "initials": "J"}, {"family": "Wang", "given": "De-Yun", "initials": "DY"}, {"family": "Waserman", "given": "Susan", "initials": "S"}, {"family": "Yorgancioglu", "given": "Arzu", "initials": "A"}, {"family": "Yusuf", "given": "Osman M", "initials": "OM"}, {"family": "Zernotti", "given": "Mario", "initials": "M"}, {"family": "Zidarn", "given": "Mihaela", "initials": "M"}, {"family": "Chivato", "given": "Tomas", "initials": "T"}, {"family": "Akdis", "given": "Cezmi A", "initials": "CA"}, {"family": "Zuberbier", "given": "Torsten", "initials": "T"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}], "type": "journal article", "published": "2021-04-02", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": null, "issue": null, "issn-l": "0105-4538"}, "abstract": "Older adults, especially men and/or those with diabetes, hypertension and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritised to receive COVID-19 vaccines due to high risk of death. In very rare instances,the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society)Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients.", "doi": "10.1111/all.14838", "pmid": "33811358", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-06T10:15:54.054Z", "modified": "2021-04-06T10:16:15.682Z"}, {"entity": "publication", "iuid": "8082603cfb84438f9809c0b184885fdc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8082603cfb84438f9809c0b184885fdc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8082603cfb84438f9809c0b184885fdc"}}, "title": "Discovery and in-vitro evaluation of potent SARS-CoV-2 entry inhibitors", "authors": [{"family": "Acharya", "given": "Arpan", "initials": "A"}, {"family": "Pandey", "given": "Kabita", "initials": "K"}, {"family": "Thurman", "given": "Michellie", "initials": "M"}, {"family": "Klug", "given": "Elizabeth", "initials": "E"}, {"family": "Trivedi", "given": "Jay", "initials": "J"}, {"family": "Lorson", "given": "Christian L", "initials": "CL"}, {"family": "Singh", "given": "Kamal", "initials": "K"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}], "type": "posted-content", "published": "2021-04-02", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.02.438204", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-08T19:11:49.891Z", "modified": "2021-04-13T14:00:41.357Z"}, {"entity": "publication", "iuid": "ce0079b35926485894db26d862a5b815", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ce0079b35926485894db26d862a5b815.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ce0079b35926485894db26d862a5b815"}}, "title": "Timing of COVID-19 Vaccine in the setting of anti-CD20 Therapy: A Primer for Nephrologists.", "authors": [{"family": "Kant", "given": "Sam", "initials": "S"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Salas", "given": "Antonio", "initials": "A"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Geetha", "given": "Duvuru", "initials": "D"}], "type": "editorial", "published": "2021-04-01", "journal": {"title": "Kidney Int Rep", "issn": "2468-0249", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.ekir.2021.03.876", "pmid": "33821223", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2468-0249(21)01023-8"}, {"db": "pmc", "key": "PMC8012272"}], "notes": [], "created": "2021-04-07T10:09:52.138Z", "modified": "2021-04-07T10:09:52.160Z"}, {"entity": "publication", "iuid": "caaa85e601364323bba233d68338fc43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/caaa85e601364323bba233d68338fc43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/caaa85e601364323bba233d68338fc43"}}, "title": "Recommendations for accurate genotyping of SARS-CoV-2 using amplicon-based sequencing of clinical samples.", "authors": [{"family": "Kubik", "given": "Slawomir", "initials": "S"}, {"family": "Marques", "given": "Ana Claudia", "initials": "AC"}, {"family": "Xing", "given": "Xiaobin", "initials": "X"}, {"family": "Silvery", "given": "Janine", "initials": "J"}, {"family": "Bertelli", "given": "Claire", "initials": "C"}, {"family": "De Maio", "given": "Flavio", "initials": "F"}, {"family": "Pournaras", "given": "Spyros", "initials": "S"}, {"family": "Burr", "given": "Tom", "initials": "T"}, {"family": "Duffourd", "given": "Yannis", "initials": "Y"}, {"family": "Siemens", "given": "Helena", "initials": "H"}, {"family": "Alloui", "given": "Chakib", "initials": "C"}, {"family": "Song", "given": "Lin", "initials": "L"}, {"family": "Wenger", "given": "Yvan", "initials": "Y"}, {"family": "Saitta", "given": "Alexandra", "initials": "A"}, {"family": "Macheret", "given": "Morgane", "initials": "M"}, {"family": "Smith", "given": "Ewan W", "initials": "EW"}, {"family": "Menu", "given": "Philippe", "initials": "P"}, {"family": "Brayer", "given": "Marion", "initials": "M"}, {"family": "Steinmetz", "given": "Lars M", "initials": "LM"}, {"family": "Si-Mohammed", "given": "Ali", "initials": "A"}, {"family": "Chuisseu", "given": "Josiane", "initials": "J"}, {"family": "Stevens", "given": "Richard", "initials": "R"}, {"family": "Constantoulakis", "given": "Pantelis", "initials": "P"}, {"family": "Sali", "given": "Michela", "initials": "M"}, {"family": "Greub", "given": "Gilbert", "initials": "G"}, {"family": "Tiemann", "given": "Carsten", "initials": "C"}, {"family": "Pelechano", "given": "Vicent", "initials": "V"}, {"family": "Willig", "given": "Adrian", "initials": "A"}, {"family": "Xu", "given": "Zhenyu", "initials": "Z"}], "type": "journal article", "published": "2021-04-01", "journal": {"title": "Clin Microbiol Infect", "issn": "1469-0691", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "SARS-CoV-2 genotyping has been instrumental to monitor viral evolution and transmission during the pandemic. The quality of the sequence data obtained from these genotyping efforts depends on several factors, including the quantity/integrity of the input material, the technology as well as laboratory-specific implementation. The current lack of guidelines for SARS-CoV-2 genotyping leads to inclusion of error-containing genome sequences in genomic epidemiology studies. We aimed at establishing clear and broadly applicable recommendations for reliable virus genotyping.\r\n\r\nWe established and used a sequencing data analysis workflow that reliably identifies and removes technical artifacts, which can result in miscalls when using alternative pipelines, to process clinical samples and synthetic viral genomes with an amplicon-based genotyping approach. We evaluated the impact of experimental factors, including viral load and sequencing depth, on correct sequence determination.\r\n\r\nWe found that at least 1000 viral genomes are necessary to confidently detect variants in the SARS-CoV-2 genome at frequencies of 10% or higher. The broad applicability of our recommendations was validated in over 200 clinical samples from six independent laboratories. The genotypes we determined for clinical isolates with sufficient quality cluster by sampling location and period. Our analysis also supports the rise in frequency of 20A.EU1 and 20A.EU2, two recently reported European strains whose dissemination was facilitated by travelling during the summer of 2020.\r\n\r\nWe present much-needed recommendations for reliable determination of SARS-CoV-2 genome sequence and demonstrate their broad applicability in a large cohort of clinical samples.", "doi": "10.1016/j.cmi.2021.03.029", "pmid": "33813118", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(21)00164-6"}, {"db": "URL", "key": "https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(21)00164-6/fulltext#appsec1", "description": "Data generated with clinical samples can be requested using this information (not suitable for public sharing)"}, {"db": "URL", "key": "https://www.ncbi.nlm.nih.gov/bioproject/PRJNA681574/", "description": "Alternative direct link to SRA (accession: PRJNA681574)"}, {"db": "SRA", "key": "PRJNA681574", "description": "Datasets generated with synthetic SARS-CoV-2 genome"}], "notes": [], "created": "2021-04-06T10:07:38.680Z", "modified": "2021-11-18T11:50:20.495Z"}, {"entity": "publication", "iuid": "60195903649d4bde89045ff87647bbd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60195903649d4bde89045ff87647bbd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60195903649d4bde89045ff87647bbd0"}}, "title": "Maintenance of Acute Stroke Care Service During the COVID-19 Pandemic Lockdown.", "authors": [{"family": "Altersberger", "given": "Valerian L", "initials": "VL"}, {"family": "Stolze", "given": "Lotte J", "initials": "LJ"}, {"family": "Heldner", "given": "Mirjam R", "initials": "MR"}, {"family": "Henon", "given": "Hilde", "initials": "H"}, {"family": "Martinez-Majander", "given": "Nicolas", "initials": "N"}, {"family": "Hametner", "given": "Christian", "initials": "C"}, {"family": "Nordanstig", "given": "Annika", "initials": "A"}, {"family": "Zini", "given": "Andrea", "initials": "A"}, {"family": "Nannoni", "given": "Stefania", "initials": "S"}, {"family": "Gon\u00e7alves", "given": "Bruno", "initials": "B"}, {"family": "Nolte", "given": "Christian H", "initials": "CH"}, {"family": "Baumgartner", "given": "Philipp", "initials": "P"}, {"family": "Kastrup", "given": "Andreas", "initials": "A"}, {"family": "Papanagiotou", "given": "Panagiotis", "initials": "P"}, {"family": "K\u00e4gi", "given": "Georg", "initials": "G"}, {"family": "Leker", "given": "Ronen R", "initials": "RR"}, {"family": "Zedde", "given": "Marialuisa", "initials": "M"}, {"family": "Padovani", "given": "Alessandro", "initials": "A"}, {"family": "Pezzini", "given": "Alessandro", "initials": "A"}, {"family": "Padjen", "given": "Visnja", "initials": "V"}, {"family": "Cereda", "given": "Carlo W", "initials": "CW"}, {"family": "Ntaios", "given": "Georges", "initials": "G"}, {"family": "Bonati", "given": "Leo H", "initials": "LH"}, {"family": "Rinkel", "given": "Leon A", "initials": "LA"}, {"family": "Fischer", "given": "Urs", "initials": "U"}, {"family": "Scheitz", "given": "Jan F", "initials": "JF"}, {"family": "Wegener", "given": "Susanne", "initials": "S"}, {"family": "Turc", "given": "Guillaume", "initials": "G"}, {"family": "Michel", "given": "Patrik", "initials": "P"}, {"family": "Gentile", "given": "Mauro", "initials": "M"}, {"family": "Rentzos", "given": "Alexandros", "initials": "A"}, {"family": "Ringleb", "given": "Peter A", "initials": "PA"}, {"family": "Curtze", "given": "Sami", "initials": "S"}, {"family": "Cordonnier", "given": "Charlotte", "initials": "C"}, {"family": "Arnold", "given": "Marcel", "initials": "M"}, {"family": "Nederkoorn", "given": "Paul J", "initials": "PJ"}, {"family": "Engelter", "given": "Stefan T", "initials": "ST"}, {"family": "Gensicke", "given": "Henrik", "initials": "H"}, {"family": "TRISP Collaborators", "given": "", "initials": ""}], "type": "journal article", "published": "2021-04-01", "journal": {"title": "Stroke", "issn": "1524-4628", "volume": null, "issue": null, "pages": "STROKEAHA120032176", "issn-l": null}, "abstract": "Timely reperfusion is an important goal in treatment of eligible patients with acute ischemic stroke. However, during the coronavirus disease 2019 (COVID-19) pandemic, prehospital and in-hospital emergency procedures faced unprecedented challenges, which might have caused a decline in the number of acute reperfusion therapy applied and led to a worsening of key quality measures for this treatment during lockdown.\n\nThis prospective multicenter cohort study used data from the TRISP (Thrombolysis in Ischemic Stroke Patients) registry of patients with acute ischemic stroke treated with reperfusion therapies, that is, intravenous thrombolysis or endovascular therapy. We compared prehospital and in-hospital time-based performance measures (stroke-onset-to-admission, admission-to-treatment, admission-to-image, and image-to-treatment time) during the first 6 weeks after announcement of lockdown (lockdown period) with the same period in 2019 (reference period). Secondary outcomes included stroke severity (National Institutes of Health Stroke Scale) after 24 hours and occurrence of symptomatic intracranial hemorrhage (following the ECASS [European-Australasian Acute Stroke Study]-II criteria).\n\nAcross 20 stroke centers, 540 patients were treated with intravenous thrombolysis/endovascular therapy during lockdown period compared with 578 patients during reference period (-7% [95% CI, 5%-9%]). Performance measures did not change significantly during the lockdown period (2020/2019 minutes median: onset-to-admission 133/145; admission-to-treatment 51/48). Same was true for admission-to-image (20/19) and image-to-treatment (31/30) time in patients with available time of first image (n=871, 77.9%). Median National Institutes of Health Stroke Scale on admission (2020/2019: 11/11) and after 24 hours (2020/2019: 6/5) and percentage of symptomatic intracranial hemorrhage (2020/2019: 6.2/5.7) did not differ significantly between both periods.\n\nThe COVID-19 pandemic lockdown resulted in a mild decline in the number of patients with stroke treated with acute reperfusion therapies. More importantly, the solid stability of key quality performance measures between the 2020 and 2019 period may indicate resilience of acute stroke care service during the lockdown, at least in well-established European stroke centers.", "doi": "10.1161/STROKEAHA.120.032176", "pmid": "33793320", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-06T10:42:44.558Z", "modified": "2021-04-06T10:42:44.569Z"}, {"entity": "publication", "iuid": "d31d1eec18a14cf2a8bd848d0d096265", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d31d1eec18a14cf2a8bd848d0d096265.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d31d1eec18a14cf2a8bd848d0d096265"}}, "title": "Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites", "authors": [{"family": "Hoffmann", "given": "David", "initials": "D"}, {"family": "Mereiter", "given": "Stefan", "initials": "S", "orcid": "0000-0002-4832-3090", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1974c14a7be4583a96ceecccbda4f19.json"}}, {"family": "Oh", "given": "Yoo Jin", "initials": "YJ", "orcid": "0000-0002-9636-3329", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6887c6a78da44881aa30920d96f17d8f.json"}}, {"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Zhu", "given": "Rong", "initials": "R"}, {"family": "Canena", "given": "Daniel", "initials": "D"}, {"family": "Hain", "given": "Lisa", "initials": "L"}, {"family": "Laurent", "given": "Elisabeth", "initials": "E"}, {"family": "Gr\u00fcnwald-Gruber", "given": "Clemens", "initials": "C"}, {"family": "Novatchkova", "given": "Maria", "initials": "M"}, {"family": "Ticevic", "given": "Melita", "initials": "M"}, {"family": "Chabloz", "given": "Antoine", "initials": "A"}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G"}, {"family": "Hagelkruys", "given": "Astrid", "initials": "A"}, {"family": "Altmann", "given": "Friedrich", "initials": "F"}, {"family": "Mach", "given": "Lukas", "initials": "L", "orcid": "0000-0001-9013-5408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e58ab479be1e4abd9f95f0c5737f280b.json"}}, {"family": "Stadlmann", "given": "Johannes", "initials": "J"}, {"family": "Oostenbrink", "given": "Chris", "initials": "C"}, {"family": "Mirazimi", "given": "Ali", "initials": "A", "orcid": "0000-0003-2371-6055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0651be47429c4e5880a13b839d04fe1d.json"}}, {"family": "Hinterdorfer", "given": "Peter", "initials": "P"}, {"family": "Penninger", "given": "Josef M", "initials": "JM", "orcid": "0000-0002-8194-3777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e56aaa008524272bf252df804e06991.json"}}], "type": "posted-content", "published": "2021-04-01", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.01.438087", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-06-09T11:13:03.497Z", "modified": "2021-08-23T14:40:45.988Z"}, {"entity": "publication", "iuid": "5e7d630904214962b1b9fca8e55d053c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e7d630904214962b1b9fca8e55d053c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e7d630904214962b1b9fca8e55d053c"}}, "title": "Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge.", "authors": [{"family": "Winkler", "given": "Martin S", "initials": "MS"}, {"family": "Skirecki", "given": "Tomasz", "initials": "T"}, {"family": "Brunkhorst", "given": "Frank M", "initials": "FM"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "Cavaillon", "given": "Jean-Marc", "initials": "JM"}, {"family": "Ferrer", "given": "Ricard", "initials": "R"}, {"family": "Floh\u00e9", "given": "Stefanie B", "initials": "SB"}, {"family": "Garc\u00eda-Salido", "given": "Alberto", "initials": "A"}, {"family": "Giamarellos-Bourboulis", "given": "Evangelos J", "initials": "EJ"}, {"family": "Girardis", "given": "Massimo", "initials": "M"}, {"family": "Kox", "given": "Matthijs", "initials": "M"}, {"family": "Lachmann", "given": "Gunnar", "initials": "G"}, {"family": "Martin-Loeches", "given": "Ignacio", "initials": "I"}, {"family": "Netea", "given": "Mihai G", "initials": "MG"}, {"family": "Spinetti", "given": "Thibaud", "initials": "T"}, {"family": "Schefold", "given": "Joerg C", "initials": "JC"}, {"family": "Torres", "given": "Antoni", "initials": "A"}, {"family": "Uhle", "given": "Florian", "initials": "F"}, {"family": "Venet", "given": "Fabienne", "initials": "F"}, {"family": "Weis", "given": "Sebastian", "initials": "S"}, {"family": "Scherag", "given": "Andr\u00e9", "initials": "A"}, {"family": "Rubio", "given": "Ignacio", "initials": "I"}, {"family": "Osuchowski", "given": "Marcin F", "initials": "MF"}], "type": "journal article", "published": "2021-04-01", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "volume": "66", "issue": null, "pages": "103291", "issn-l": null}, "abstract": "Many milestones in medical history rest on animal modeling of human diseases. The SARS-CoV-2 pandemic has evoked a tremendous investigative effort primarily centered on clinical studies. However, several animal SARS-CoV-2/COVID-19 models have been developed and pre-clinical findings aimed at supporting clinical evidence rapidly emerge. In this review, we characterize the existing animal models exposing their relevance and limitations as well as outline their utility in COVID-19 drug and vaccine development. Concurrently, we summarize the status of clinical trial research and discuss the novel tactics utilized in the largest multi-center trials aiming to accelerate generation of reliable results that may subsequently shape COVID-19 clinical treatment practices. We also highlight areas of improvement for animal studies in order to elevate their translational utility. In pandemics, to optimize the use of strained resources in a short time-frame, optimizing and strengthening the synergy between the preclinical and clinical domains is pivotal.", "doi": "10.1016/j.ebiom.2021.103291", "pmid": "33813139", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2352-3964(21)00084-0"}], "notes": [], "created": "2021-04-06T10:06:30.011Z", "modified": "2021-04-06T10:06:30.022Z"}, {"entity": "publication", "iuid": "8ed7dd2bcc9d426189a98e28e0f3d1f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ed7dd2bcc9d426189a98e28e0f3d1f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ed7dd2bcc9d426189a98e28e0f3d1f2"}}, "title": "Using the COVID-19 pandemic to reimagine global health teaching in high-income countries.", "authors": [{"family": "Atkins", "given": "Salla", "initials": "S"}, {"family": "Banerjee", "given": "Ananya Tina", "initials": "AT"}, {"family": "Bachynski", "given": "Kathleen", "initials": "K"}, {"family": "Daftary", "given": "Amrita", "initials": "A"}, {"family": "Desai", "given": "Gauri", "initials": "G"}, {"family": "Gross", "given": "Aeyal", "initials": "A"}, {"family": "Hedt-Gauthier", "given": "Bethany", "initials": "B"}, {"family": "Mendenhall", "given": "Emily", "initials": "E"}, {"family": "Meier", "given": "Benjamin Mason", "initials": "BM"}, {"family": "Nixon", "given": "Stephanie A", "initials": "SA"}, {"family": "Nolan", "given": "Ann", "initials": "A"}, {"family": "Palermo", "given": "Tia M", "initials": "TM"}, {"family": "Phelan", "given": "Alexandra", "initials": "A"}, {"family": "Pyzik", "given": "Oksana", "initials": "O"}, {"family": "Roach", "given": "Pamela", "initials": "P"}, {"family": "Sangaramoorthy", "given": "Thurka", "initials": "T"}, {"family": "Standley", "given": "Claire J", "initials": "CJ"}, {"family": "Yamey", "given": "Gavin", "initials": "G"}, {"family": "Abimbola", "given": "Seye", "initials": "S"}, {"family": "Pai", "given": "Madhukar", "initials": "M"}], "type": "editorial", "published": "2021-04-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "4", "issn-l": "2059-7908"}, "abstract": null, "doi": "10.1136/bmjgh-2021-005649", "pmid": "33811100", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-005649"}], "notes": [], "created": "2021-04-06T10:22:25.858Z", "modified": "2021-04-06T10:22:25.868Z"}, {"entity": "publication", "iuid": "95af88ba4a9a4369936c0f0d5dcea2d8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95af88ba4a9a4369936c0f0d5dcea2d8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95af88ba4a9a4369936c0f0d5dcea2d8"}}, "title": "Undiagnosed SARS-CoV-2 infection and outcome in patients with acute MI and no COVID-19 symptoms.", "authors": [{"family": "Akhtar", "given": "Zubair", "initials": "Z"}, {"family": "Chowdhury", "given": "Fahmida", "initials": "F"}, {"family": "Aleem", "given": "Mohammad Abdul", "initials": "MA"}, {"family": "Ghosh", "given": "Probir Kumar", "initials": "PK"}, {"family": "Rahman", "given": "Mahmudur", "initials": "M"}, {"family": "Rahman", "given": "Mustafizur", "initials": "M"}, {"family": "Hossain", "given": "Mohammad Enayet", "initials": "ME"}, {"family": "Sumiya", "given": "Mariya Kibtiya", "initials": "MK"}, {"family": "Islam", "given": "A K M Monwarul", "initials": "AKMM"}, {"family": "Uddin", "given": "Mir Jamal", "initials": "MJ"}, {"family": "MacIntyre", "given": "C Raina", "initials": "CR"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "Frobert", "given": "Ole", "initials": "O"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Open Heart", "issn": "2053-3624", "volume": "8", "issue": "1", "issn-l": null}, "abstract": "We aimed to determine the prevalence and outcome of occult infection with SARS-CoV-2 and influenza in patients presenting with myocardial infarction (MI) without COVID-19 symptoms.\n\nWe conducted an observational study from 28 June to 11 August 2020, enrolling patients admitted to the National Institute of Cardiovascular Disease Hospital, Dhaka, Bangladesh, with ST-segment elevation MI (STEMI) or non-ST-segment elevation MI who did not meet WHO criteria for suspected COVID-19. Samples were collected by nasopharyngeal swab to test for SARS-CoV-2 and influenza virus by real-time reverse transcriptase PCR. We followed up patients at 3 months (13 weeks) postadmission to record adverse cardiovascular outcomes: all-cause death, new MI, heart failure and new percutaneous coronary intervention or stent thrombosis. Survival analysis was performed using the Kaplan-Meier method.\n\nWe enrolled 280 patients with MI, 79% male, mean age 54.5\u00b111.8 years, 140 of whom were diagnosed with STEMI. We found 36 (13%) to be infected with SARS-CoV-2 and 1 with influenza. There was no significant difference between mortality rate observed among SARS-CoV-2 infected patients compared with non-infected (5 (14%) vs 26 (11%); p=0.564). A numerically shorter median time to a recurrent cardiovascular event was recorded among SARS-CoV-2 infected compared with non-infected patients (21 days, IQR: 8-46 vs 27 days, IQR: 7-44; p=0.378).\n\nWe found a substantial rate of occult SARS-CoV-2 infection in the studied cohort, suggesting SARS-CoV-2 may precipitate MI. Asymptomatic patients with COVID-19 admitted with MI may contribute to disease transmission and warrants widespread testing of hospital admissions.", "doi": "10.1136/openhrt-2021-001617", "pmid": "33811137", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "openhrt-2021-001617"}], "notes": [], "created": "2021-04-06T10:19:09.211Z", "modified": "2021-04-06T10:21:37.251Z"}, {"entity": "publication", "iuid": "274bda03653b48a7b4e0a8099fda6a9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/274bda03653b48a7b4e0a8099fda6a9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/274bda03653b48a7b4e0a8099fda6a9c"}}, "title": "Second versus first wave of COVID-19 deaths: Shifts in age distribution and in nursing home fatalities.", "authors": [{"family": "Ioannidis", "given": "John P A", "initials": "JPA"}, {"family": "Axfors", "given": "Cathrine", "initials": "C"}, {"family": "Contopoulos-Ioannidis", "given": "Despina G", "initials": "DG"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Environ Res", "issn": "1096-0953", "volume": "195", "issue": null, "pages": "110856", "issn-l": "0013-9351"}, "abstract": "To examine whether the age distribution of COVID-19 deaths and the share of deaths in nursing homes changed in the second versus the first pandemic wave.\n\nWe considered all countries that had at least 4000 COVID-19 deaths occurring as of January 14, 2021, at least 200 COVID-19 deaths occurring in each of the two epidemic wave periods; and which had sufficiently detailed information available on the age distribution of these deaths. We also considered countries with data available on COVID-19 deaths of nursing home residents for the two waves.\n\nChange in the second wave versus the first wave in the proportion of COVID-19 deaths occurring in people <50 years (\"young deaths\") among all COVID-19 deaths and among COVID-19 deaths in people <70 years old; and change in the proportion of COVID-19 deaths in nursing home residents among all COVID-19 deaths.\n\nData on age distribution were available for 14 eligible countries. Individuals <50 years old had small absolute difference in their share of the total COVID-19 deaths in the two waves across 13 high-income countries (absolute differences 0.0-0.4%). Their proportion was higher in Ukraine, but it decreased markedly in the second wave. The proportion of young deaths was lower in the second versus the first wave (summary prevalence ratio 0.81, 95% CI 0.71-0.92) with large between-country heterogeneity. The proportion of young deaths among deaths <70 years did not differ significantly across the two waves (summary prevalence ratio 0.96, 95% CI 0.86-1.06). Eligible data on nursing home COVID-19 deaths were available for 11 countries. The share of COVID-19 deaths that were accounted by nursing home residents decreased in the second wave significantly and substantially in 8 countries (prevalence ratio estimates: 0.36 to 0.78), remained the same in Denmark and Norway and markedly increased in Australia.\n\nIn the examined countries, age distribution of COVID-19 deaths has been fairly similar in the second versus the first wave, but the contribution of COVID-19 deaths in nursing home residents to total fatalities has decreased in most countries in the second wave.", "doi": "10.1016/j.envres.2021.110856", "pmid": "33581086", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0013-9351(21)00150-X"}, {"db": "pmc", "key": "PMC7875012"}], "notes": [], "created": "2021-02-15T07:51:34.990Z", "modified": "2021-07-14T07:56:41.505Z"}, {"entity": "publication", "iuid": "d302fafc56674dd383657bc91dd6780e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d302fafc56674dd383657bc91dd6780e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d302fafc56674dd383657bc91dd6780e"}}, "title": "Reporting suspicions of long COVID in children is justified during this global emergency.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF", "orcid": "0000-0003-1024-5602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1d5e45881a7469ca20a0eb360d891cc.json"}}], "type": "letter", "published": "2021-04-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": "110", "issue": "4", "pages": "1373"}, "abstract": "I would like to thank Peny and Valind (1) for raising a number of issues with regard to my recent paper in Acta Paediatrica, which was based on parental reports of what appeared to be long COVID in Sweden (2). The parents approached a number of medical professionals, including me, following discussions on social media about how their children were experiencing worrying ongoing symptoms during the current COVID-19 pandemic.", "doi": "10.1111/apa.15762", "pmid": "33459404", "labels": {"Type: Other": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC8013867"}], "notes": [], "created": "2021-01-22T09:17:52.957Z", "modified": "2021-07-09T12:50:41.953Z"}, {"entity": "publication", "iuid": "85e87380177046388d486d1e87652a60", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/85e87380177046388d486d1e87652a60.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/85e87380177046388d486d1e87652a60"}}, "title": "OncoAlert Round Table Discussions: The Global COVID-19 Experience.", "authors": [{"family": "Morgan", "given": "Gilberto", "initials": "G"}, {"family": "de Azambuja", "given": "Evandro", "initials": "E"}, {"family": "Punie", "given": "Kevin", "initials": "K"}, {"family": "Ades", "given": "Felipe", "initials": "F"}, {"family": "Heinrich", "given": "Kathrin", "initials": "K"}, {"family": "Personeni", "given": "Nicola", "initials": "N"}, {"family": "Rahme", "given": "Ramy", "initials": "R"}, {"family": "Ferrara", "given": "Roberto", "initials": "R"}, {"family": "Pels", "given": "Kevin", "initials": "K"}, {"family": "Garassino", "given": "Marina", "initials": "M"}, {"family": "von Bergwelt-Baildon", "given": "Michael", "initials": "M"}, {"family": "Lopes", "given": "Gilberto", "initials": "G"}, {"family": "Barlesi", "given": "Fabrice", "initials": "F"}, {"family": "Choueiri", "given": "Toni K", "initials": "TK"}, {"family": "Burris", "given": "Howard", "initials": "H"}, {"family": "Peters", "given": "Solange", "initials": "S"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "JCO Glob Oncol", "issn": "2687-8941", "volume": "7", "issue": null, "pages": "455-463", "issn-l": null}, "abstract": "The speed and spread of the COVID-19 pandemic has been affecting the entire world for the past several months. OncoAlert is a social media network made up of more than 140 oncology stakeholders: oncologists (medical, radiation, and surgical), oncology nurses, and patient advocates who share the mission of fighting cancer by means of education and dissemination of information. As a response to the COVID-19 pandemic, OncoAlert hosted The Round Table Discussions. We have documented this effort along with further discussion about the COVID-19 pandemic and the consequences on patients living with cancer to disseminate this information to our colleagues worldwide.", "doi": "10.1200/GO.20.00603", "pmid": "33822643", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-07T10:07:54.625Z", "modified": "2021-04-07T10:07:54.648Z"}, {"entity": "publication", "iuid": "ee6c4a2899d04e1682c03838cdd1d575", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee6c4a2899d04e1682c03838cdd1d575.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee6c4a2899d04e1682c03838cdd1d575"}}, "title": "No country or continent is on its own in the ongoing COVID-19 pandemic.", "authors": [{"family": "Johansen", "given": "Kari", "initials": "K"}, {"family": "Nohynek", "given": "Hanna", "initials": "H"}], "type": "editorial", "published": "2021-04-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "17", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2021.26.17.2100430", "pmid": "33928901", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-04T16:03:43.303Z", "modified": "2021-05-04T16:03:43.313Z"}, {"entity": "publication", "iuid": "68d673b1ce8746409bf731b7cf161c36", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68d673b1ce8746409bf731b7cf161c36.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68d673b1ce8746409bf731b7cf161c36"}}, "title": "Next-generation field courses: Integrating Open Science and online learning.", "authors": [{"family": "Geange", "given": "Sonya R", "initials": "SR"}, {"family": "von Oppen", "given": "Jonathan", "initials": "J"}, {"family": "Strydom", "given": "Tanya", "initials": "T"}, {"family": "Boakye", "given": "Mickey", "initials": "M"}, {"family": "Gauthier", "given": "Tasha-Leigh J", "initials": "TJ"}, {"family": "Gya", "given": "Ragnhild", "initials": "R"}, {"family": "Halbritter", "given": "Aud H", "initials": "AH"}, {"family": "Jessup", "given": "Laura H", "initials": "LH"}, {"family": "Middleton", "given": "Sara L", "initials": "SL"}, {"family": "Navarro", "given": "Jocelyn", "initials": "J"}, {"family": "Pierfederici", "given": "Maria Elisa", "initials": "ME"}, {"family": "Chac\u00f3n-Labella", "given": "Julia", "initials": "J"}, {"family": "Cotner", "given": "Sehoya", "initials": "S"}, {"family": "Farfan-Rios", "given": "William", "initials": "W"}, {"family": "Maitner", "given": "Brian S", "initials": "BS"}, {"family": "Michaletz", "given": "Sean T", "initials": "ST"}, {"family": "Telford", "given": "Richard J", "initials": "RJ"}, {"family": "Enquist", "given": "Brian J", "initials": "BJ"}, {"family": "Vandvik", "given": "Vigdis", "initials": "V"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Ecol Evol", "issn": "2045-7758", "volume": "11", "issue": "8", "pages": "3577-3587", "issn-l": null}, "abstract": "As Open Science practices become more commonplace, there is a need for the next generation of scientists to be well versed in these aspects of scientific research. Yet, many training opportunities for early career researchers (ECRs) could better emphasize or integrate Open Science elements. Field courses provide opportunities for ECRs to apply theoretical knowledge, practice new methodological approaches, and gain an appreciation for the challenges of real-life research, and could provide an excellent platform for integrating training in Open Science practices. Our recent experience, as primarily ECRs engaged in a field course interrupted by COVID-19, led us to reflect on the potential to enhance learning outcomes in field courses by integrating Open Science practices and online learning components. Specifically, we highlight the opportunity for field courses to align teaching activities with the recent developments and trends in how we conduct research, including training in: publishing registered reports, collecting data using standardized methods, adopting high-quality data documentation, managing data through reproducible workflows, and sharing and publishing data through appropriate channels. We also discuss how field courses can use online tools to optimize time in the field, develop open access resources, and cultivate collaborations. By integrating these elements, we suggest that the next generation of field courses will offer excellent arenas for participants to adopt Open Science practices.", "doi": "10.1002/ece3.7009", "pmid": "33898010", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "ECE37009"}, {"db": "pmc", "key": "PMC8057340"}], "notes": [], "created": "2021-04-29T15:27:05.229Z", "modified": "2021-04-29T15:27:05.232Z"}, {"entity": "publication", "iuid": "0d45ddfcbc5047b09fbf45d48525b320", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d45ddfcbc5047b09fbf45d48525b320.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d45ddfcbc5047b09fbf45d48525b320"}}, "title": "National outcomes and characteristics of patients admitted to Swedish intensive care units for COVID-19", "authors": [{"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Blixt", "given": "Patrik Johansson", "initials": "PJ"}, {"family": "\u00c5hman", "given": "Rasmus", "initials": "R"}, {"family": "Engerstr\u00f6m", "given": "Lars", "initials": "L"}, {"family": "Andersson", "given": "Henrik", "initials": "H"}, {"family": "Berggren", "given": "Ritva Kiiski", "initials": "RK"}, {"family": "Tegnell", "given": "Anders", "initials": "A"}, {"family": "McIntyre", "given": "Sarah", "initials": "S"}], "type": "journal-article", "published": "2021-04-00", "journal": {"title": "Eur J Anaesthesiol", "issn": "1365-2346", "volume": "38", "issue": "4", "pages": "335-343", "issn-l": null}, "abstract": "Mortality among patients admitted to intensive care units (ICUs) with COVID-19 is unclear due to variable follow-up periods. Few nationwide data are available to compare risk factors, treatment and outcomes of COVID-19 patients after ICU admission.\n\nTo evaluate baseline characteristics, treatments and 30-day outcomes of patients admitted to Swedish ICUs with COVID-19.\n\nRegistry-based cohort study with prospective data collection.\n\nAdmissions to Swedish ICUs from 6 March to 6 May 2020 with laboratory confirmed COVID-19 disease.\n\nAdult patients admitted to Swedish ICUs.\n\nBaseline characteristics, intensive care treatments and organ failures.\n\nThe primary outcome was 30-day all-cause mortality. A multivariable model was used to determine the independent association between potential predictor variables and death.\n\nWe identified 1563 patients with complete 30-day follow-up. The 30-day all-cause mortality was 26.7%. Median age was 61 [52 to 69], Simplified Acute Physiology Score III (SAPS III) was 53 [46 to 59] and 62.5% had at least one comorbidity. Median PaO2/FiO2 on admission was 97.5 [75.0 to 140.6] mmHg, 74.7% suffered from moderate-to-severe acute respiratory failure. Age, male sex [adjusted odds ratio (aOR) 1.5 (1.1 to 2.2)], SAPS III score [aOR 1.3 (1.2 to 1.4)], severe respiratory failure [aOR 3.0 (2.0 to 4.7)], specific COVID-19 pharmacotherapy [aOR 1.4 (1.0 to 1.9)] and continuous renal replacement therapy [aOR 2.1 (1.5 to 3.0)] were associated with increased mortality. Except for chronic lung disease, the presence of comorbidities was not independently associated with mortality.\n\nThirty-day mortality rate in COVID-19 patients admitted to Swedish ICUs is generally lower than previously reported despite a severe degree of hypoxaemia on admission. Mortality was driven by age, baseline disease severity, the presence and degree of organ failure, rather than pre-existing comorbidities.\n\nNCT04462393.", "doi": "10.1097/eja.0000000000001459", "pmid": "33534266", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00003643-900000000-98244"}, {"db": "ClinicalTrials.gov", "key": "NCT04462393"}], "notes": [], "created": "2021-02-04T18:11:08.535Z", "modified": "2021-06-18T11:08:26.474Z"}, {"entity": "publication", "iuid": "980eb41a0b4c42ee9233958785cdf896", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/980eb41a0b4c42ee9233958785cdf896.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/980eb41a0b4c42ee9233958785cdf896"}}, "title": "Meteorological conditions are heterogeneous factors for COVID-19 risk in China", "authors": [{"family": "Xiao", "given": "Shuang", "initials": "S"}, {"family": "Qi", "given": "Hongchao", "initials": "H"}, {"family": "Ward", "given": "Michael P", "initials": "MP"}, {"family": "Wang", "given": "Wenge", "initials": "W"}, {"family": "Zhang", "given": "Jun", "initials": "J"}, {"family": "Chen", "given": "Yue", "initials": "Y"}, {"family": "Bergquist", "given": "Robert", "initials": "R"}, {"family": "Tu", "given": "Wei", "initials": "W"}, {"family": "Shi", "given": "Runye", "initials": "R"}, {"family": "Hong", "given": "Jie", "initials": "J"}, {"family": "Su", "given": "Qing", "initials": "Q"}, {"family": "Zhao", "given": "Zheng", "initials": "Z"}, {"family": "Ba", "given": "Jianbo", "initials": "J"}, {"family": "Zhang", "given": "Zhijie", "initials": "Z"}], "type": "journal-article", "published": "2021-04-00", "journal": {"title": "Environ Res", "issn": "0013-9351", "volume": null, "issue": null, "pages": "111182", "issn-l": null}, "abstract": null, "doi": "10.1016/j.envres.2021.111182", "pmid": null, "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-04-20T17:52:22.865Z", "modified": "2021-04-23T16:06:36.046Z"}, {"entity": "publication", "iuid": "15dfd044b9124bebb7e41ae9a130eb62", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15dfd044b9124bebb7e41ae9a130eb62.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15dfd044b9124bebb7e41ae9a130eb62"}}, "title": "Long-Haul Post-COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrome: The Swedish Experience.", "authors": [{"family": "Johansson", "given": "Madeleine", "initials": "M"}, {"family": "St\u00e5hlberg", "given": "Marcus", "initials": "M"}, {"family": "Runold", "given": "Michael", "initials": "M"}, {"family": "Nygren-Bonnier", "given": "Malin", "initials": "M"}, {"family": "Nilsson", "given": "Jan", "initials": "J"}, {"family": "Olshansky", "given": "Brian", "initials": "B"}, {"family": "Bruchfeld", "given": "Judith", "initials": "J"}, {"family": "Fedorowski", "given": "Artur", "initials": "A"}], "type": "case reports", "published": "2021-04-00", "journal": {"title": "JACC Case Rep", "issn": "2666-0849", "issn-l": null, "volume": "3", "issue": "4", "pages": "573-580"}, "abstract": "Major clinical centers in Sweden have witnessed an inflow of patients with chronic symptoms following initial outpatient care for coronavirus disease-2019 (COVID-19) infection, suggestive of postural orthostatic tachycardia syndrome. This report presents the first case series of 3 Swedish patients diagnosed with postural orthostatic tachycardia syndrome more than 3 months after the primary COVID-2019 infections. (Level of Difficulty: Intermediate.).", "doi": "10.1016/j.jaccas.2021.01.009", "pmid": "33723532", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Rehabilitation": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "S2666-0849(21)00100-5"}, {"db": "pmc", "key": "PMC7946344"}], "notes": [], "created": "2021-03-17T07:42:54.636Z", "modified": "2021-11-18T12:53:34.532Z"}, {"entity": "publication", "iuid": "7aea0412da344b4f9e2e8ac34ab5196d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7aea0412da344b4f9e2e8ac34ab5196d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7aea0412da344b4f9e2e8ac34ab5196d"}}, "title": "Long COVID-19\u2014it's not over until?", "authors": [{"family": "Yelin", "given": "Dana", "initials": "D"}, {"family": "Margalit", "given": "Ili", "initials": "I"}, {"family": "Yahav", "given": "Dafna", "initials": "D"}, {"family": "Runold", "given": "Michael", "initials": "M"}, {"family": "Bruchfeld", "given": "Judith", "initials": "J"}], "type": "journal-article", "published": "2021-04-00", "journal": {"title": "Clinical Microbiology and Infection", "issn": "1198-743X", "issn-l": null, "volume": "27", "issue": "4", "pages": "506-508"}, "abstract": null, "doi": "10.1016/j.cmi.2020.12.001", "pmid": "33316400", "labels": {"Type: Other": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(20)30750-3"}], "notes": [], "created": "2020-12-21T10:16:50.007Z", "modified": "2021-07-09T12:52:27.295Z"}, {"entity": "publication", "iuid": "1abc7e14a86640049e495cf1c27e887e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1abc7e14a86640049e495cf1c27e887e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1abc7e14a86640049e495cf1c27e887e"}}, "title": "Incidence of SARS-CoV-2 in people with cystic fibrosis in Europe between February and June 2020", "authors": [{"family": "Naehrlich", "given": "Lutz", "initials": "L"}, {"family": "Orenti", "given": "Annalisa", "initials": "A"}, {"family": "Dunlevy", "given": "Fiona", "initials": "F"}, {"family": "Kasmi", "given": "Irena", "initials": "I"}, {"family": "Harutyunyan", "given": "Satenik", "initials": "S"}, {"family": "Pfleger", "given": "Andreas", "initials": "A"}, {"family": "Keegan", "given": "Svetlana", "initials": "S"}, {"family": "Daneau", "given": "G\u00e9raldine", "initials": "G"}, {"family": "Petrova", "given": "Guergana", "initials": "G"}, {"family": "Tje\u0161i\u0107-Drinkovi\u0107", "given": "Du\u0161ka", "initials": "D"}, {"family": "Yiallouros", "given": "Panayiotis", "initials": "P"}, {"family": "Bilkova", "given": "Alena", "initials": "A"}, {"family": "Olesen", "given": "Hanne Vebert", "initials": "HV"}, {"family": "Burgel", "given": "Pierre R\u00e9gis", "initials": "PR"}, {"family": "Parulava", "given": "Tsitsino", "initials": "T"}, {"family": "Diamantea", "given": "Filia", "initials": "F"}, {"family": "P\u00e1rniczky", "given": "Andrea", "initials": "A"}, {"family": "McKone", "given": "Edward F", "initials": "EF"}, {"family": "Mei-Zahav", "given": "Meir", "initials": "M"}, {"family": "Salvatore", "given": "Marco", "initials": "M"}, {"family": "Colombo", "given": "Carla", "initials": "C"}, {"family": "Aleksejeva", "given": "Elina", "initials": "E"}, {"family": "Malakauskas", "given": "Kestutis", "initials": "K"}, {"family": "Schlesser", "given": "Marc", "initials": "M"}, {"family": "Fustik", "given": "Stojka", "initials": "S"}, {"family": "Turcu", "given": "Oxana", "initials": "O"}, {"family": "Zomer-van Ommen", "given": "Domenique", "initials": "D"}, {"family": "Wathne", "given": "Anita Senstad", "initials": "AS"}, {"family": "Wo\u017aniacki", "given": "\u0141ukasz", "initials": "\u0141"}, {"family": "Pereira", "given": "Lu\u00edsa", "initials": "L"}, {"family": "Pop", "given": "Liviu", "initials": "L"}, {"family": "Kashirskaya", "given": "Nataliya", "initials": "N"}, {"family": "Rodi\u0107", "given": "Milan", "initials": "M"}, {"family": "Kayserova", "given": "Hana", "initials": "H"}, {"family": "Krivecs", "given": "Uro", "initials": "U"}, {"family": "Mondejar-Lopez", "given": "Pedro", "initials": "P"}, {"family": "de Monestrol", "given": "Isabelle", "initials": "I"}, {"family": "Dogru", "given": "Deniz", "initials": "D"}, {"family": "Makukh", "given": "Halyna", "initials": "H"}, {"family": "Cosgriff", "given": "Rebecca", "initials": "R"}, {"family": "van Koningsbruggen-Rietschel", "given": "Silke", "initials": "S"}, {"family": "Jung", "given": "Andreas", "initials": "A"}, {"family": "Bobrovnichy", "given": "Vladimir", "initials": "V"}, {"family": "Bambir", "given": "Ivan", "initials": "I"}, {"family": "Vukic", "given": "Andrea Dugac", "initials": "AD"}, {"family": "Drevinek", "given": "Pavel", "initials": "P"}, {"family": "Jr", "given": "Milan Macek", "initials": "MM"}, {"family": "Corvol", "given": "Harriet", "initials": "H"}, {"family": "Lemonnier-Videau", "given": "Lydie", "initials": "L"}, {"family": "Hatziagorou", "given": "Elpis", "initials": "E"}, {"family": "Fletcher", "given": "Godfrey", "initials": "G"}, {"family": "Padoan", "given": "Rita", "initials": "R"}, {"family": "Gulmans", "given": "Vincent", "initials": "V"}, {"family": "Bakkeheim", "given": "Egil", "initials": "E"}, {"family": "Kondratyeva", "given": "Elena", "initials": "E"}, {"family": "Amelina", "given": "Elena", "initials": "E"}, {"family": "Zhekaite", "given": "Elena", "initials": "E"}, {"family": "Simonova", "given": "Olga", "initials": "O"}, {"family": "Pastor-Vivero", "given": "Maria Dolores", "initials": "MD"}, {"family": "Lindblad", "given": "Anders", "initials": "A"}, {"family": "G\u00f6kdemir", "given": "Yasemin", "initials": "Y"}, {"family": "Pekcan", "given": "Sevgi", "initials": "S"}, {"family": "Brownlee", "given": "Keith", "initials": "K"}, {"family": "McClenaghan", "given": "Elliott", "initials": "E"}, {"family": "Carr", "given": "Siobh\u00e1n", "initials": "S"}, {"family": "Lammertyn", "given": "Elise", "initials": "E"}, {"family": "Zolin", "given": "Anna", "initials": "A"}, {"family": "Fox", "given": "Alice", "initials": "A"}, {"family": "Krasnyk", "given": "Marko", "initials": "M"}, {"family": "Van Rens", "given": "Jacqui", "initials": "J"}], "type": "journal-article", "published": "2021-04-00", "journal": {"title": "Journal of Cystic Fibrosis", "issn": "1569-1993", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.jcf.2021.03.017", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-21T17:25:33.722Z", "modified": "2021-05-21T17:25:55.844Z"}, {"entity": "publication", "iuid": "1782e69f4e5249c29b177151ee5e172b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1782e69f4e5249c29b177151ee5e172b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1782e69f4e5249c29b177151ee5e172b"}}, "title": "From a crisis to an opportunity: Eight insights for doing science in the COVID-19 era and beyond.", "authors": [{"family": "Chac\u00f3n-Labella", "given": "Julia", "initials": "J"}, {"family": "Boakye", "given": "Mickey", "initials": "M"}, {"family": "Enquist", "given": "Brian J", "initials": "BJ"}, {"family": "Farfan-Rios", "given": "William", "initials": "W"}, {"family": "Gya", "given": "Ragnhild", "initials": "R"}, {"family": "Halbritter", "given": "Aud H", "initials": "AH"}, {"family": "Middleton", "given": "Sara L", "initials": "SL"}, {"family": "von Oppen", "given": "Jonathan", "initials": "J"}, {"family": "Pastor-Ploskonka", "given": "Samuel", "initials": "S"}, {"family": "Strydom", "given": "Tanya", "initials": "T"}, {"family": "Vandvik", "given": "Vigdis", "initials": "V"}, {"family": "Geange", "given": "Sonya R", "initials": "SR"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Ecol Evol", "issn": "2045-7758", "volume": "11", "issue": "8", "pages": "3588-3596", "issn-l": null}, "abstract": "The COVID-19 crisis has forced researchers in Ecology to change the way we work almost overnight. Nonetheless, the pandemic has provided us with several novel components for a new way of conducting science. In this perspective piece, we summarize eight central insights that are helping us, as early career researchers, navigate the uncertainties, fears, and challenges of advancing science during the COVID-19 pandemic. We highlight how innovative, collaborative, and often Open Science-driven developments that have arisen from this crisis can form a blueprint for a community reinvention in academia. Our insights include personal approaches to managing our new reality, maintaining capacity to focus and resilience in our projects, and a variety of tools that facilitate remote collaboration. We also highlight how, at a community level, we can take advantage of online communication platforms for gaining accessibility to conferences and meetings, and for maintaining research networks and community engagement while promoting a more diverse and inclusive community. Overall, we are confident that these practices can support a more inclusive and kinder scientific culture for the longer term.", "doi": "10.1002/ece3.7026", "pmid": "33898011", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "ECE37026"}, {"db": "pmc", "key": "PMC8057324"}], "notes": [], "created": "2021-04-29T10:30:06.622Z", "modified": "2021-04-29T10:31:02.408Z"}, {"entity": "publication", "iuid": "bd9a35673402475f8d9617e727313371", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bd9a35673402475f8d9617e727313371.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bd9a35673402475f8d9617e727313371"}}, "title": "Error rates in SARS-CoV-2 testing examined with Bayes' theorem.", "authors": [{"family": "Bentley", "given": "P M", "initials": "PM"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": "7", "issue": "4", "pages": "e06905", "issn-l": null}, "abstract": "The SARS-CoV-2 pandemic has created a demand for large scale testing, as part of the effort to understand and control transmission. It is important to quantify the error rates of test equipment under field conditions, which might differ significantly from those obtained in the laboratory. A literature review on SARS-CoV-2 reverse-transcription polymerase chain reaction (RT-PCR) is used to construct a clinical test confusion matrix. A simple correction method for bulk test results is then demonstrated with examples. The required sensitivity and specificity of a test are explored for societal needs and use cases, before a sequential analysis of common example scenarios is explored. The analysis suggests that many of the people with mild symptoms and positive test results are unlikely to be infected with SARS-CoV-2 in some regions. It is concluded that current and foreseen alternative tests can not be used to \"clear\" people as being non-infected. Recommendations are given that regional authorities must establish a programme to monitor operational test characteristics before launching large scale testing; and that large scale testing for tracing infection networks in some regions is not viable, but may be possible in a focused way that does not exceed the working capacity of the laboratories staffed by competent experts. RT-PCR tests can not be solely relied upon as the gold standard for SARS-CoV-2 diagnosis at scale, instead clinical assessment supported by a range of expert diagnostic tests should be used.", "doi": "10.1016/j.heliyon.2021.e06905", "pmid": "33937546", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)01008-2"}, {"db": "pmc", "key": "PMC8080131"}], "notes": [], "created": "2021-05-04T15:58:32.202Z", "modified": "2021-05-04T15:58:32.212Z"}, {"entity": "publication", "iuid": "54926588f7d343be90f590e89292ffa1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54926588f7d343be90f590e89292ffa1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54926588f7d343be90f590e89292ffa1"}}, "title": "Elevated factor V activity and antigen levels in patients with Covid\u201019 are related to disease severity and 30\u2010day mortality", "authors": [{"family": "Meijenfeldt", "given": "Fien A", "initials": "FA", "orcid": "0000-0003-0274-2414", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76b5cb67f6e243459441f06d41f0816c.json"}}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Adelmeijer", "given": "Jelle", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Thalin", "given": "Charlotte", "initials": "C"}, {"family": "Lisman", "given": "Ton", "initials": "T", "orcid": "0000-0002-3503-7140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7431e810d13c443ca5dacbf5d368e60b.json"}}], "type": "journal-article", "published": "2021-04-00", "journal": {"title": "Am J Hematol", "issn": "0361-8609", "issn-l": null, "volume": "96", "issue": "4", "pages": null}, "abstract": null, "doi": "10.1002/ajh.26085", "pmid": "33393103", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-04T16:18:01.104Z", "modified": "2021-12-12T18:06:38.589Z"}, {"entity": "publication", "iuid": "6263eec832f54ef69a97f6d3d0c37763", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6263eec832f54ef69a97f6d3d0c37763.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6263eec832f54ef69a97f6d3d0c37763"}}, "title": "Effectiveness of the Comirnaty (BNT162b2, BioNTech/Pfizer) vaccine in preventing SARS-CoV-2 infection among healthcare workers, Treviso province, Veneto region, Italy, 27 December 2020 to 24 March 2021.", "authors": [{"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Ramigni", "given": "Mauro", "initials": "M"}, {"family": "Gobbetto", "given": "Valentina", "initials": "V"}, {"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Piovesan", "given": "Cinzia", "initials": "C"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "17", "issn-l": null}, "abstract": "Data on effectiveness of the BioNTech-/Pfizer COVID-19 vaccine in real-world settings are limited. In a study of 6,423 healthcare workers in Treviso Province, Italy, we estimated that, within the time intervals of 14-21 days from the first and at least 7 days from the second dose, vaccine effectiveness in preventing SARS-CoV-2 infection was 84% (95% confidence interval (CI): 40-96) and 95% (95% CI: 62-99), respectively. These results could support the ongoing vaccination campaigns by providing evidence for targeted communication.", "doi": "10.2807/1560-7917.ES.2021.26.17.2100420", "pmid": "33928898", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-05-04T16:04:18.214Z", "modified": "2021-05-04T16:04:18.224Z"}, {"entity": "publication", "iuid": "9931c97142514ddaa8f78e17e737d5fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9931c97142514ddaa8f78e17e737d5fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9931c97142514ddaa8f78e17e737d5fd"}}, "title": "Dependence of SARS-CoV-2 infection on cholesterol-rich lipid raft and endosomal acidification", "authors": [{"family": "Li", "given": "Xiaowei", "initials": "X"}, {"family": "Zhu", "given": "Wenhua", "initials": "W"}, {"family": "Fan", "given": "Meiyang", "initials": "M"}, {"family": "Zhang", "given": "Jing", "initials": "J"}, {"family": "Peng", "given": "Yizhao", "initials": "Y"}, {"family": "Huang", "given": "Fumeng", "initials": "F"}, {"family": "Wang", "given": "Nan", "initials": "N"}, {"family": "He", "given": "Langchong", "initials": "L"}, {"family": "Zhang", "given": "Lei", "initials": "L"}, {"family": "Holmdahl", "given": "Rikard", "initials": "R"}, {"family": "Meng", "given": "Liesu", "initials": "L"}, {"family": "Lu", "given": "Shemin", "initials": "S"}], "type": "journal-article", "published": "2021-04-00", "journal": {"title": "Comput Struct Biotechnol J", "issn": "2001-0370", "issn-l": "2001-0370", "volume": null, "issue": null, "pages": null}, "abstract": "Coronavirus disease 2019 is a kind of viral pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the mechanism whereby SARS-CoV-2 invades host cells remains poorly understood. Here we used SARS-CoV-2 pseudoviruses to infect human angiotensin-converting enzyme 2 (ACE2) expressing HEK293T cells and evaluated virus infection. We confirmed that SARS-CoV-2 entry was dependent on ACE2 and sensitive to pH of endosome/lysosome in HEK293T cells. The infection of SARS-CoV-2 pseudoviruses is independent of dynamin, clathrin, caveolin and endophilin A2, as well as macropinocytosis. Instead, we found that the infection of SARS-CoV-2 pseudoviruses was cholesterol-rich lipid raft dependent. Cholesterol depletion of cell membranes with methyl-\u03b2-cyclodextrin resulted in reduction of pseudovirus infection. The infection of SARS-CoV-2 pseudoviruses resumed with cholesterol supplementation. Together, cholesterol-rich lipid rafts, and endosomal acidification, are key steps of SARS-CoV-2 required for infection of host cells. Therefore, our finding expands the understanding of SARS-CoV-2 entry mechanism and provides a new anti-SARS-CoV-2 strategy.", "doi": "10.1016/j.csbj.2021.04.001", "pmid": "33850607", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-15T10:33:48.387Z", "modified": "2021-04-21T08:55:37.850Z"}, {"entity": "publication", "iuid": "587fb02cc83e473a8da6f20bc7edafce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/587fb02cc83e473a8da6f20bc7edafce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/587fb02cc83e473a8da6f20bc7edafce"}}, "title": "Cloth Masks May Prevent Transmission of COVID-19", "authors": [{"family": "Clase", "given": "Catherine M", "initials": "CM"}, {"family": "Fu", "given": "Edouard L", "initials": "EL"}, {"family": "Jardine", "given": "Meg", "initials": "M"}, {"family": "Mann", "given": "Johannes F E", "initials": "JFE"}, {"family": "Carrero", "given": "Juan J", "initials": "JJ"}], "type": "journal-article", "published": "2021-04-00", "journal": {"title": "Ann Intern Med", "issn": "0003-4819", "volume": "174", "issue": "4", "pages": "580", "issn-l": null}, "abstract": null, "doi": "10.7326/l21-0091", "pmid": null, "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-04-20T17:52:54.999Z", "modified": "2021-04-20T17:52:55.012Z"}, {"entity": "publication", "iuid": "d5a7eec396b04e21a41f59382f5a79ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5a7eec396b04e21a41f59382f5a79ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5a7eec396b04e21a41f59382f5a79ee"}}, "title": "Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021.", "authors": [{"family": "Funk", "given": "Tjede", "initials": "T"}, {"family": "Pharris", "given": "Anastasia", "initials": "A"}, {"family": "Spiteri", "given": "Gianfranco", "initials": "G"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "Carr", "given": "Michael", "initials": "M"}, {"family": "Gonzalez", "given": "Gabriel", "initials": "G"}, {"family": "Garcia-Leon", "given": "Alejandro", "initials": "A"}, {"family": "Crispie", "given": "Fiona", "initials": "F"}, {"family": "O'Connor", "given": "Lois", "initials": "L"}, {"family": "Murphy", "given": "Niamh", "initials": "N"}, {"family": "Mossong", "given": "Jo\u00ebl", "initials": "J"}, {"family": "Vergison", "given": "Anne", "initials": "A"}, {"family": "Wienecke-Baldacchino", "given": "Anke K", "initials": "AK"}, {"family": "Abdelrahman", "given": "Tamir", "initials": "T"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Di Martino", "given": "Angela", "initials": "A"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Lo Presti", "given": "Alessandra", "initials": "A"}, {"family": "Casaca", "given": "Pedro", "initials": "P"}, {"family": "Moreno", "given": "Joana", "initials": "J"}, {"family": "Borges", "given": "V\u00edtor", "initials": "V"}, {"family": "Isidro", "given": "Joana", "initials": "J"}, {"family": "Ferreira", "given": "Rita", "initials": "R"}, {"family": "Gomes", "given": "Jo\u00e3o Paulo", "initials": "JP"}, {"family": "Dotsenko", "given": "Liidia", "initials": "L"}, {"family": "Suija", "given": "Heleene", "initials": "H"}, {"family": "Epstein", "given": "Jevgenia", "initials": "J"}, {"family": "Sadikova", "given": "Olga", "initials": "O"}, {"family": "Sepp", "given": "Hanna", "initials": "H"}, {"family": "Ikonen", "given": "Niina", "initials": "N"}, {"family": "Savolainen-Kopra", "given": "Carita", "initials": "C"}, {"family": "Blomqvist", "given": "Soile", "initials": "S"}, {"family": "M\u00f6tt\u00f6nen", "given": "Teemu", "initials": "T"}, {"family": "Helve", "given": "Otto", "initials": "O"}, {"family": "Gomes-Dias", "given": "Joana", "initials": "J"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "COVID study groups", "given": "", "initials": ""}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "16", "issn-l": null}, "abstract": "We compared 19,207 cases of SARS-CoV-2 variant B.1.1.7/S gene target failure (SGTF), 436 B.1.351 and 352 P.1 to non-variant cases reported by seven European countries. COVID-19 cases with these variants had significantly higher adjusted odds ratios for hospitalisation (B.1.1.7/SGTF: 1.7, 95% confidence interval (CI): 1.0-2.9; B.1.351: 3.6, 95% CI: 2.1-6.2; P.1: 2.6, 95% CI: 1.4-4.8) and B.1.1.7/SGTF and P.1 cases also for intensive care admission (B.1.1.7/SGTF: 2.3, 95% CI: 1.4-3.5; P.1: 2.2, 95% CI: 1.7-2.8).", "doi": "10.2807/1560-7917.ES.2021.26.16.2100348", "pmid": "33890566", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "URL", "key": "https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2021.26.16.2100348", "description": "All data is included in the supplementary material"}], "notes": [], "created": "2021-04-29T15:38:29.078Z", "modified": "2021-11-18T12:55:13.856Z"}, {"entity": "publication", "iuid": "f80c158699b2466c9ef82f8f15e35e63", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f80c158699b2466c9ef82f8f15e35e63.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f80c158699b2466c9ef82f8f15e35e63"}}, "title": "Attributes and predictors of long COVID.", "authors": [{"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Murray", "given": "Benjamin", "initials": "B", "orcid": "0000-0002-2413-923X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebec738df0224bf4874fd6c08fd23fae.json"}}, {"family": "Varsavsky", "given": "Thomas", "initials": "T"}, {"family": "Graham", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-4170-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f5f4e19812a46ed9e873732ec25e28d.json"}}, {"family": "Penfold", "given": "Rose S", "initials": "RS"}, {"family": "Bowyer", "given": "Ruth C", "initials": "RC", "orcid": "0000-0002-6941-8160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eebaf361c184499ca6729aa60cc0af3d.json"}}, {"family": "Pujol", "given": "Joan Capdevila", "initials": "JC", "orcid": "0000-0003-1658-1076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60965a027a4b4d048728748f09c98594.json"}}, {"family": "Klaser", "given": "Kerstin", "initials": "K"}, {"family": "Antonelli", "given": "Michela", "initials": "M"}, {"family": "Canas", "given": "Liane S", "initials": "LS"}, {"family": "Molteni", "given": "Erika", "initials": "E", "orcid": "0000-0001-7773-8140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9aed1fbe444b48d4bfacb12050953c8e.json"}}, {"family": "Modat", "given": "Marc", "initials": "M"}, {"family": "Jorge Cardoso", "given": "M", "initials": "M", "orcid": "0000-0003-1284-2558", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0ed3abec67644e186650e1d1dcbbe0b.json"}}, {"family": "May", "given": "Anna", "initials": "A"}, {"family": "Ganesh", "given": "Sajaysurya", "initials": "S", "orcid": "0000-0002-3720-4176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6dbf91180806442082ce6732c1b75923.json"}}, {"family": "Davies", "given": "Richard", "initials": "R", "orcid": "0000-0003-2050-3994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b82cc92615f462d9af0153a6fb94fde.json"}}, {"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Drew", "given": "David A", "initials": "DA", "orcid": "0000-0002-8813-0816", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd3a2cffdc104f18b8684cf4f27d68b2.json"}}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Merino", "given": "Jordi", "initials": "J", "orcid": "0000-0001-8312-1438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12ab049914a542b39affcfb4196861d2.json"}}, {"family": "Tsereteli", "given": "Neli", "initials": "N"}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f34c0d3602439abe6096293c7c732d.json"}}, {"family": "Gomez", "given": "Maria F", "initials": "MF", "orcid": "0000-0001-6210-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e09e37219c4f42c8a7b3a982da523859.json"}}, {"family": "Duncan", "given": "Emma L", "initials": "EL"}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874802ae65824a90ba50eabdeabb8356.json"}}, {"family": "Williams", "given": "Frances M K", "initials": "FMK", "orcid": "0000-0002-2998-2744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87a6db988c2e421f81fce7773436aefa.json"}}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74cf1f7094744ee289fa5df041e7cb5b.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-7284-6767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeefbf47fd384d5390109fe1a903bd18.json"}}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Ourselin", "given": "Sebastien", "initials": "S", "orcid": "0000-0002-5694-5340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74c7b9b1633144879042d198c7205656.json"}}, {"family": "Spector", "given": "Tim", "initials": "T", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956", "volume": "27", "issue": "4", "pages": "626-631"}, "abstract": "Reports of long-lasting coronavirus disease 2019 (COVID-19) symptoms, the so-called 'long COVID', are rising but little is known about prevalence, risk factors or whether it is possible to predict a protracted course early in the disease. We analyzed data from 4,182 incident cases of COVID-19 in which individuals self-reported their symptoms prospectively in the COVID Symptom Study app1. A total of 558 (13.3%) participants reported symptoms lasting \u226528 days, 189 (4.5%) for \u22658 weeks and 95 (2.3%) for \u226512 weeks. Long COVID was characterized by symptoms of fatigue, headache, dyspnea and anosmia and was more likely with increasing age and body mass index and female sex. Experiencing more than five symptoms during the first week of illness was associated with long COVID (odds ratio = 3.53 (2.76-4.50)). A simple model to distinguish between short COVID and long COVID at 7 days (total sample size, n = 2,149) showed an area under the curve of the receiver operating characteristic curve of 76%, with replication in an independent sample of 2,472 individuals who were positive for severe acute respiratory syndrome coronavirus 2. This model could be used to identify individuals at risk of long COVID for trials of prevention or treatment and to plan education and rehabilitation services.", "doi": "10.1038/s41591-021-01292-y", "pmid": "33692530", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "mid", "key": "EMS131037"}, {"db": "pmc", "key": "PMC7611399"}, {"db": "pii", "key": "10.1038/s41591-021-01292-y"}], "notes": [], "created": "2021-01-07T16:47:03.626Z", "modified": "2023-06-19T15:07:13.510Z"}, {"entity": "publication", "iuid": "3a7826632dde417d8a75ee0117438d85", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a7826632dde417d8a75ee0117438d85.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a7826632dde417d8a75ee0117438d85"}}, "title": "Assessing mandatory stay-at-home and business closure effects on the spread of COVID-19.", "authors": [{"family": "Bendavid", "given": "Eran", "initials": "E", "orcid": "0000-0002-8364-4711", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79b88b45b7634279bdcb7b3629caae9f.json"}}, {"family": "Oh", "given": "Christopher", "initials": "C"}, {"family": "Bhattacharya", "given": "Jay", "initials": "J", "orcid": "0000-0003-3867-3174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12aad76bb20d4b29b500b194f3e84d17.json"}}, {"family": "Ioannidis", "given": "John P A", "initials": "JPA", "orcid": "0000-0003-3118-6859", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9844ea41bc554157a721820d7986a442.json"}}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Eur J Clin Invest", "issn": "1365-2362", "volume": "51", "issue": "4", "pages": "e13484", "issn-l": null}, "abstract": "The most restrictive nonpharmaceutical interventions (NPIs) for controlling the spread of COVID-19 are mandatory stay-at-home and business closures. Given the consequences of these policies, it is important to assess their effects. We evaluate the effects on epidemic case growth of more restrictive NPIs (mrNPIs), above and beyond those of less-restrictive NPIs (lrNPIs).\n\nWe first estimate COVID-19 case growth in relation to any NPI implementation in subnational regions of 10 countries: England, France, Germany, Iran, Italy, Netherlands, Spain, South Korea, Sweden and the United States. Using first-difference models with fixed effects, we isolate the effects of mrNPIs by subtracting the combined effects of lrNPIs and epidemic dynamics from all NPIs. We use case growth in Sweden and South Korea, 2 countries that did not implement mandatory stay-at-home and business closures, as comparison countries for the other 8 countries (16 total comparisons).\n\nImplementing any NPIs was associated with significant reductions in case growth in 9 out of 10 study countries, including South Korea and Sweden that implemented only lrNPIs (Spain had a nonsignificant effect). After subtracting the epidemic and lrNPI effects, we find no clear, significant beneficial effect of mrNPIs on case growth in any country. In France, for example, the effect of mrNPIs was +7% (95% CI: -5%-19%) when compared with Sweden and + 13% (-12%-38%) when compared with South Korea (positive means pro-contagion). The 95% confidence intervals excluded 30% declines in all 16 comparisons and 15% declines in 11/16 comparisons.\n\nWhile small benefits cannot be excluded, we do not find significant benefits on case growth of more restrictive NPIs. Similar reductions in case growth may be achievable with less-restrictive interventions.", "doi": "10.1111/eci.13484", "pmid": "33400268", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7883103"}], "notes": [], "created": "2023-01-13T13:30:03.001Z", "modified": "2023-01-13T13:30:03.092Z"}, {"entity": "publication", "iuid": "cbb613cf35da41c8be1815197e30108d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cbb613cf35da41c8be1815197e30108d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cbb613cf35da41c8be1815197e30108d"}}, "title": "SARS-CoV-2 infection incidence during the first and second COVID-19 waves in Italy.", "authors": [{"family": "Vinceti", "given": "Marco", "initials": "M"}, {"family": "Filippini", "given": "Tommaso", "initials": "T"}, {"family": "Rothman", "given": "Kenneth J", "initials": "KJ"}, {"family": "Di Federico", "given": "Silvia", "initials": "S"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}], "type": "journal article", "published": "2021-03-31", "journal": {"title": "Environ Res", "issn": "1096-0953", "volume": null, "issue": null, "pages": "111097", "issn-l": "0013-9351"}, "abstract": "We assessed the relation between Covid-19 waves in Italy, which was severely affected during the pandemic. We evaluated the hypothesis that a larger impact from the first wave (February-March 2020) predicts a smaller peak during the second wave (September-October), in the absence of local changes in public health interventions and area-specific differences in time trends of environmental parameters. Based on publicly available data on province-specific SARS-CoV-2 infections and both crude and multivariable cubic spline regression models, we found that for provinces with the lowest incidence rates in the first wave, the incidence in the second wave increased roughly in proportion with the incidence in the first wave until an incidence of about 500-600 cases/100,000 in the first wave. Above that value, provinces with higher incidences in the first wave experienced lower incidences in the second wave. It appears that a comparatively high cumulative incidence of infection, even if far below theoretical thresholds required for herd immunity, may provide noticeable protection during the second wave. We speculate that, if real, the mechanism for this pattern could be depletion of most susceptible individuals and of superspreaders in the first wave. A population learning effect regarding cautious behavior could have also contributed. Since no area-specific variation of the national policy against the SARS-CoV-2 outbreak was allowed until early November 2020, neither individual behaviours nor established or purported environmental risk factors of Covid-19, such as air pollution and meteorological factors, are likely to have confounded the inverse trends we observed in infection incidence over time.", "doi": "10.1016/j.envres.2021.111097", "pmid": "33811866", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0013-9351(21)00391-1"}], "notes": [], "created": "2021-04-06T10:11:10.599Z", "modified": "2021-04-06T10:11:10.610Z"}, {"entity": "publication", "iuid": "9951948df6af47d19567e1e5335019c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9951948df6af47d19567e1e5335019c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9951948df6af47d19567e1e5335019c5"}}, "title": "Report from the CVOT Summit 2020: new cardiovascular and renal outcomes.", "authors": [{"family": "Schnell", "given": "Oliver", "initials": "O"}, {"family": "Cos", "given": "Xavier", "initials": "X"}, {"family": "Cosentino", "given": "Francesco", "initials": "F"}, {"family": "Forst", "given": "Thomas", "initials": "T"}, {"family": "Giorgino", "given": "Francesco", "initials": "F"}, {"family": "Heersprink", "given": "Hiddo J L", "initials": "HJL"}, {"family": "Kosiborod", "given": "Mikhail", "initials": "M"}, {"family": "Wanner", "given": "Christoph", "initials": "C"}, {"family": "Standl", "given": "Eberhard", "initials": "E"}], "type": "editorial", "published": "2021-03-31", "journal": {"title": "Cardiovasc Diabetol", "issn": "1475-2840", "volume": "20", "issue": "1", "pages": "75", "issn-l": null}, "abstract": "The 6th Cardiovascular Outcome Trial (CVOT) Summit \"Cardiovascular and Renal Outcomes 2020\" was the first to be held virtually on October 29-30, 2020. As in previous years, this summit served as reference meeting for in-depth discussions on the topic of recently completed and presented major outcome trials. This year, focus was placed on the outcomes of VERTIS-CV, EMPEROR-Reduced, DAPA-CKD, and FIDELIO-DKD. Trial implications for diabetes management and the impact on new treatment algorithms were highlighted for diabetologists, cardiologists, endocrinologists, nephrologists, and general practitioners. Discussion evolved from major outcome trials using SGLT-2 inhibitors for treatment and prevention of heart failure and chronic kidney disease in people with and without diabetes, to additional therapy options for chronic kidney disease with a novel mineralocorticoid receptor antagonist. Furthermore, challenges in diabetes management like COVID-19 and obesity, as well as novel treatment strategies and guidelines, were discussed.The 7th Cardiovascular Outcome Trial Summit will be held virtually on November, 18-19, 2021 ( http://www.cvot.org ).", "doi": "10.1186/s12933-021-01254-1", "pmid": "33789663", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12933-021-01254-1"}, {"db": "pmc", "key": "PMC8010779"}], "notes": [], "created": "2021-04-06T10:39:05.268Z", "modified": "2021-04-06T10:39:05.290Z"}, {"entity": "publication", "iuid": "a0636447716b4b328bbc5bd67a94da12", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a0636447716b4b328bbc5bd67a94da12.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a0636447716b4b328bbc5bd67a94da12"}}, "title": "Immunotherapy may protect cancer patients from SARS-CoV-2 infection: a single-center retrospective analysis.", "authors": [{"family": "Isgr\u00f2", "given": "Maria Antonietta", "initials": "MA"}, {"family": "Vitale", "given": "Maria Grazia", "initials": "MG"}, {"family": "Celentano", "given": "Egidio", "initials": "E"}, {"family": "Nocerino", "given": "Flavia", "initials": "F"}, {"family": "Porciello", "given": "Giuseppe", "initials": "G"}, {"family": "Curvietto", "given": "Marcello", "initials": "M"}, {"family": "Mallardo", "given": "Domenico", "initials": "D"}, {"family": "Montagnese", "given": "Concetta", "initials": "C"}, {"family": "Russo", "given": "Luigi", "initials": "L"}, {"family": "Zanaletti", "given": "Nicoletta", "initials": "N"}, {"family": "Avallone", "given": "Antonio", "initials": "A"}, {"family": "Pensabene", "given": "Matilde", "initials": "M"}, {"family": "De Laurentiis", "given": "Michelino", "initials": "M"}, {"family": "Centonze", "given": "Sara", "initials": "S"}, {"family": "Pignata", "given": "Sandro", "initials": "S"}, {"family": "Cannella", "given": "Lucia", "initials": "L"}, {"family": "Morabito", "given": "Alessandro", "initials": "A"}, {"family": "Caponigro", "given": "Francesco", "initials": "F"}, {"family": "Botti", "given": "Gerardo", "initials": "G"}, {"family": "Masucci", "given": "Giuseppe Valentino", "initials": "GV"}, {"family": "Giannarelli", "given": "Diana", "initials": "D"}, {"family": "Cavalcanti", "given": "Ernesta", "initials": "E"}, {"family": "Ascierto", "given": "Paolo Antonio", "initials": "PA"}], "type": "journal article", "published": "2021-03-31", "journal": {"title": "J Transl Med", "issn": "1479-5876", "volume": "19", "issue": "1", "pages": "132", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) global pandemic has created unique challenges to healthcare systems throughout the world. Ensuring subjects' safety is mandatory especially in oncology, in consideration of cancer patients' particular frailty. We examined the proportion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgM and/or IgG positive subjects in three different groups from Istituto Nazionale Tumori - IRCCS \"Fondazione G. Pascale\" in Naples (Campania region, Italy): cancer patients treated with Innovative Immunotherapy (Immune Checkpoint Inhibitors, ICIs), cancer patients undergoing standard Chemotherapies (CHTs) and healthcare providers. 9 out of 287 (3.1%) ICIs patients resulted positive, with a significant lower percentage in respect to CHTs patients (39 positive subjects out of 598, 6.5%) (p = 0.04). There was no statistically significant difference between ICIs cohort and healthcare providers, 48 out of 1050 resulting positive (4.6%). Performing a Propensity Score Matching based on gender and tumor stage, the effect of treatment on seropositivity was analyzed through a regression logistic model and the ICIs treatment resulted to be the only protective factor significantly (p = 0.03) associated with positivity (odds ratio-OR: 0.41; 95% confidence interval-CI 0.18-0.91). According to these preliminary data, ICIs would appear to be a protective factor against the onset of COVID-19 infection.", "doi": "10.1186/s12967-021-02798-2", "pmid": "33789686", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12967-021-02798-2"}, {"db": "pmc", "key": "PMC8010485"}], "notes": [], "created": "2021-04-06T10:44:34.189Z", "modified": "2021-04-06T10:45:15.550Z"}, {"entity": "publication", "iuid": "bc41bcd6a843474c8beee260d5a0ed27", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bc41bcd6a843474c8beee260d5a0ed27.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bc41bcd6a843474c8beee260d5a0ed27"}}, "title": "Household food insecurity and its association with self-reported male perpetration of intimate partner violence: a survey of two districts in central and western Uganda.", "authors": [{"family": "Awungafac", "given": "George", "initials": "G"}, {"family": "Mugamba", "given": "Stephen", "initials": "S"}, {"family": "Nalugoda", "given": "Fred", "initials": "F"}, {"family": "Sj\u00f6land", "given": "Carl Fredrik", "initials": "CF"}, {"family": "Kigozi", "given": "Godfrey", "initials": "G"}, {"family": "Rautiainen", "given": "Susanne", "initials": "S"}, {"family": "Malyabe", "given": "Robert Bulamba", "initials": "RB"}, {"family": "Ziegel", "given": "Leo", "initials": "L"}, {"family": "Nakigozi", "given": "Gertrude", "initials": "G"}, {"family": "Nalwoga", "given": "Grace Kigozi", "initials": "GK"}, {"family": "Kyasanku", "given": "Emmanuel", "initials": "E"}, {"family": "Nkale", "given": "James", "initials": "J"}, {"family": "Watya", "given": "Stephen", "initials": "S"}, {"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM"}, {"family": "K\u00e5gesten", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-03-31", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "3", "pages": "e045427"}, "abstract": "This study aimed to determine the lifetime prevalence of male-perpetrated intimate partner violence (IPV), and to assess the association with food insecurity, sociodemographic factors and health risk behaviours in Uganda in the year preceding COVID-19-associated lockdowns.\r\n\r\nPopulation-based, cross-sectional household survey.\r\n\r\nUrban, semiurban and rural communities of the Wakiso and Hoima districts in Uganda.\r\n\r\nA total of N=2014 males aged 13-80 years participated in the survey. The current study included males who reported having ever been in a sexual union and responded to the IPV questions (N=1314).\r\n\r\nData were collected face-to-face from May 2018 to July 2019 using an interviewer-mediated questionnaire. Lifetime IPV perpetration was measured as 'no physical and/or sexual IPV', 'physical' versus 'sexual violence only', and 'physical and sexual violence'. Past-year food insecurity was measured through the Food Insecurity Experience Scale and categorised into 'none', 'low' and 'high'. Multinomial logistic regression was used to determine the crude and adjusted relative risk ratios (aRRRs) of IPV perpetration in relation to self-reported food insecurity, adjusting for sociodemographic and health risk behaviours.\r\n\r\nThe prevalence of self-reported lifetime IPV perpetration was 14.6% for physical and 6.5% for sexual violence, while 5.3% reported to have perpetrated both physical and sexual IPV. Most (75.7%) males reported no food insecurity, followed by low (20.7%) and high (3.6%) food insecurity. In adjusted models, food insecurity was associated with increased risk of having perpetrated both physical and sexual violence (aRRR=2.57, 95% CI 1.52 to 4.32). IPV perpetration was also independently associated with having had more than one lifetime sexual partner and drinking alcohol, but not with education level or religion.\r\n\r\nThis study suggests that food insecurity is associated with male IPV perpetration, and more efforts are needed to prevent and mitigate the expected worsening of this situation as a result of the COVID-19 pandemic.", "doi": "10.1136/bmjopen-2020-045427", "pmid": "33789856", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-045427"}], "notes": [], "created": "2021-04-06T10:43:45.278Z", "modified": "2021-06-18T15:49:13.890Z"}, {"entity": "publication", "iuid": "b1cbf1dcbb51410d9addeac7af4e00a3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1cbf1dcbb51410d9addeac7af4e00a3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1cbf1dcbb51410d9addeac7af4e00a3"}}, "title": "A longitudinal assessment of depression and anxiety in the Republic of Ireland before and during the COVID-19 pandemic.", "authors": [{"family": "Hyland", "given": "Philip", "initials": "P"}, {"family": "Shevlin", "given": "Mark", "initials": "M"}, {"family": "Murphy", "given": "Jamie", "initials": "J"}, {"family": "McBride", "given": "Orla", "initials": "O"}, {"family": "Fox", "given": "Robert", "initials": "R"}, {"family": "Bondjers", "given": "Kristina", "initials": "K"}, {"family": "Karatzias", "given": "Thanos", "initials": "T"}, {"family": "Bentall", "given": "Richard P", "initials": "RP"}, {"family": "Martinez", "given": "Anton", "initials": "A"}, {"family": "Valli\u00e8res", "given": "Fr\u00e9d\u00e9rique", "initials": "F"}], "type": "journal article", "published": "2021-03-31", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "issn-l": null, "volume": "300", "issue": null, "pages": "113905"}, "abstract": "Few studies have examined changes in mental health before and after the outbreak of COVID-19. We examined changes in the prevalence of major depression and generalized anxiety disorder (GAD) between February 2019 and March-April 2020; if there were changes in major depression and GAD during six weeks of nationwide lockdown; and we identified factors that predicted major depression and GAD across the six-week lockdown period. Nationally representative samples of Irish adults were gathered using identical methods in February 2019 (N = 1020) and March-April 2020 (N = 1041). The latter was reassessed six weeks later. Significantly more people screened positive for depression in February 2019 (29.8% 95% CI = 27.0, 32.6) than in March-April 2020 (22.8% 95% CI = 20.2, 25.3), and there was no change in GAD. There were no significant changes in depression and GAD during the lockdown. Major depression was predicted by younger age, non-city dwelling, lower resilience, higher loneliness, and higher somatic problems. GAD was predicted by a broader set of variables including several COVID-19 specific variables. These findings indicate that the prevalence of major depression and GAD did not increase as a result of, or during the early phase of the COVID-19 pandemic in Ireland.", "doi": "10.1016/j.psychres.2021.113905", "pmid": "33827013", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(21)00202-X"}], "notes": [], "created": "2021-04-09T16:39:06.688Z", "modified": "2021-06-18T15:49:45.988Z"}, {"entity": "publication", "iuid": "6ed7d515b54b4351a8752f9debe15ad5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ed7d515b54b4351a8752f9debe15ad5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ed7d515b54b4351a8752f9debe15ad5"}}, "title": "Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials.", "authors": [{"family": "Jolliffe", "given": "David A", "initials": "DA"}, {"family": "Camargo", "given": "Carlos A", "initials": "CA"}, {"family": "Sluyter", "given": "John D", "initials": "JD"}, {"family": "Aglipay", "given": "Mary", "initials": "M"}, {"family": "Aloia", "given": "John F", "initials": "JF"}, {"family": "Ganmaa", "given": "Davaasambuu", "initials": "D"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Bischoff-Ferrari", "given": "Heike A", "initials": "HA"}, {"family": "Borzutzky", "given": "Arturo", "initials": "A"}, {"family": "Damsgaard", "given": "Camilla T", "initials": "CT"}, {"family": "Dubnov-Raz", "given": "Gal", "initials": "G"}, {"family": "Esposito", "given": "Susanna", "initials": "S"}, {"family": "Gilham", "given": "Clare", "initials": "C"}, {"family": "Ginde", "given": "Adit A", "initials": "AA"}, {"family": "Golan-Tripto", "given": "Inbal", "initials": "I"}, {"family": "Goodall", "given": "Emma C", "initials": "EC"}, {"family": "Grant", "given": "Cameron C", "initials": "CC"}, {"family": "Griffiths", "given": "Christopher J", "initials": "CJ"}, {"family": "Hibbs", "given": "Anna Maria", "initials": "AM"}, {"family": "Janssens", "given": "Wim", "initials": "W"}, {"family": "Khadilkar", "given": "Anuradha Vaman", "initials": "AV"}, {"family": "Laaksi", "given": "Ilkka", "initials": "I"}, {"family": "Lee", "given": "Margaret T", "initials": "MT"}, {"family": "Loeb", "given": "Mark", "initials": "M"}, {"family": "Maguire", "given": "Jonathon L", "initials": "JL"}, {"family": "Majak", "given": "Pawe\u0142", "initials": "P"}, {"family": "Mauger", "given": "David T", "initials": "DT"}, {"family": "Manaseki-Holland", "given": "Semira", "initials": "S"}, {"family": "Murdoch", "given": "David R", "initials": "DR"}, {"family": "Nakashima", "given": "Akio", "initials": "A"}, {"family": "Neale", "given": "Rachel E", "initials": "RE"}, {"family": "Pham", "given": "Hai", "initials": "H"}, {"family": "Rake", "given": "Christine", "initials": "C"}, {"family": "Rees", "given": "Judy R", "initials": "JR"}, {"family": "Rosendahl", "given": "Jenni", "initials": "J"}, {"family": "Scragg", "given": "Robert", "initials": "R"}, {"family": "Shah", "given": "Dheeraj", "initials": "D"}, {"family": "Shimizu", "given": "Yoshiki", "initials": "Y"}, {"family": "Simpson-Yap", "given": "Steve", "initials": "S"}, {"family": "Trilok-Kumar", "given": "Geeta", "initials": "G"}, {"family": "Urashima", "given": "Mitsuyoshi", "initials": "M"}, {"family": "Martineau", "given": "Adrian R", "initials": "AR"}], "type": "journal article", "published": "2021-03-30", "journal": {"title": "Lancet Diabetes Endocrinol", "issn": "2213-8595", "volume": null, "issue": null, "issn-l": null}, "abstract": "A 2017 meta-analysis of data from 25 randomised controlled trials (RCTs) of vitamin D supplementation for the prevention of acute respiratory infections (ARIs) revealed a protective effect of this intervention. We aimed to examine the link between vitamin D supplementation and prevention of ARIs in an updated meta-analysis.\n\nFor this systematic review and meta-analysis, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, and the ClinicalTrials.gov registry for studies listed from database inception to May 1, 2020. Double-blind RCTs of vitamin D 3, vitamin D2, or 25-hydroxyvitamin D (25[OH]D) supplementation for any duration, with a placebo or low-dose vitamin D control, were eligible if they had been approved by a research ethics committee, and if ARI incidence was collected prospectively and prespecified as an efficacy outcome. Studies reporting results of long-term follow-up of primary RCTs were excluded. Aggregated study-level data, stratified by baseline 25(OH)D concentration and age, were obtained from study authors. Using the proportion of participants in each trial who had one or more ARIs, we did a random-effects meta-analysis to obtain pooled odds ratios (ORs) and 95% CIs to estimate the effect of vitamin D supplementation on the risk of having one or more ARIs (primary outcome) compared with placebo. Subgroup analyses were done to estimate whether the effects of vitamin D supplementation on the risk of ARI varied according to baseline 25(OH)D concentration (<25 nmol/L vs 25\u00b70-49\u00b79 nmol/L vs 50\u00b70-74\u00b79 nmol/L vs >75\u00b70 nmol/L), vitamin D dose (daily equivalent of <400 international units [IU] vs 400-1000 IU vs 1001-2000 IU vs >2000 IU), dosing frequency (daily vs weekly vs once per month to once every 3 months), trial duration (\u226412 months vs >12 months), age at enrolment (<1\u00b700 years vs 1\u00b700-15\u00b799 years vs 16\u00b700-64\u00b799 years vs \u226565\u00b700 years), and presence versus absence of airway disease (ie, asthma only, COPD only, or unrestricted). Risk of bias was assessed with the Cochrane Collaboration Risk of Bias Tool. The study was registered with PROSPERO, CRD42020190633.\n\nWe identified 1528 articles, of which 46 RCTs (75 541 participants) were eligible. Data for the primary outcome were obtained for 48 488 (98\u00b71%) of 49 419 participants (aged 0-95 years) in 43 studies. A significantly lower proportion of participants in the vitamin D supplementation group had one or more ARIs (14 332 [61\u00b73%] of 23 364 participants) than in the placebo group (14 217 [62\u00b73%] of 22 802 participants), with an OR of 0\u00b792 (95% CI 0\u00b786-0\u00b799; 37 studies; I 2=35\u00b76%, pheterogeneity=0\u00b7018). No significant effect of vitamin D supplementation on the risk of having one or more ARIs was observed for any of the subgroups defined by baseline 25(OH)D concentration. However, protective effects of supplementation were observed in trials in which vitamin D was given in a daily dosing regimen (OR 0\u00b778 [95% CI 0\u00b765-0\u00b794]; 19 studies; I2=53\u00b75%, pheterogeneity=0\u00b7003), at daily dose equivalents of 400-1000 IU (0\u00b770 [0\u00b755-0\u00b789]; ten studies; I2=31\u00b72%, pheterogeneity=0\u00b716), for a duration of 12 months or less (0\u00b782 [0\u00b772-0\u00b793]; 29 studies; I2=38\u00b71%, pheterogeneity=0\u00b7021), and to participants aged 1\u00b700-15\u00b799 years at enrolment (0\u00b771 [0\u00b757-0\u00b790]; 15 studies; I2=46\u00b70%, pheterogeneity=0\u00b7027). No significant interaction between allocation to the vitamin D supplementation group versus the placebo group and dose, dose frequency, study duration, or age was observed. In addition, no significant difference in the proportion of participants who had at least one serious adverse event in the vitamin supplementation group compared with the placebo group was observed (0\u00b797 [0\u00b786-1\u00b707]; 36 studies; I2=0\u00b70%, pheterogeneity=0\u00b799). Risk of bias within individual studies was assessed as being low for all but three trials.\n\nDespite evidence of significant heterogeneity across trials, vitamin D supplementation was safe and overall reduced the risk of ARI compared with placebo, although the risk reduction was small. Protection was associated with administration of daily doses of 400-1000 IU for up to 12 months, and age at enrolment of 1\u00b700-15\u00b799 years. The relevance of these findings to COVID-19 is not known and requires further investigation.\n\nNone.", "doi": "10.1016/S2213-8587(21)00051-6", "pmid": "33798465", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2213-8587(21)00051-6"}], "notes": [], "created": "2021-04-06T10:40:59.319Z", "modified": "2021-04-06T10:40:59.341Z"}, {"entity": "publication", "iuid": "126cbe8fde8b4bebad2bee9b574f9e12", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/126cbe8fde8b4bebad2bee9b574f9e12.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/126cbe8fde8b4bebad2bee9b574f9e12"}}, "title": "The impact of viremia on organ failure, biomarkers and mortality in a Swedish cohort of critically ill COVID-19 patients.", "authors": [{"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Bergqvist", "given": "Anders", "initials": "A"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}], "type": "journal article", "published": "2021-03-30", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "7163"}, "abstract": "The spread of virus via the blood stream has been suggested to contribute to extra-pulmonary organ failure in Coronavirus disease 2019 (COVID-19). We assessed SARS-CoV-2 RNAemia (RNAemia) and the association between RNAemia and inflammation, organ failure and mortality in critically ill COVID-19 patients. We included all patients with PCR verified COVID-19 and consent admitted to ICU. SARS-CoV-2 RNA copies above 1000/ml measured by PCR in plasma was defined as RNAemia and used as surrogate for viremia. In this cohort of 92 patients 59 (64%) were invasively ventilated. RNAemia was found in 31 patients (34%). Hypertension and corticosteroid treatment was more common in patients with RNAemia. Extra-pulmonary organ failure biomarkers and the extent of organ failure were similar in patients with and without RNAemia, but the former group had more renal replacement therapy and higher mortality (26 vs 16%; 35 vs 16%, respectively, p = 0.04). RNAemia was not an independent predictor of death at 30 days after adjustment for age. SARS-CoV2 RNA copies in plasma is a common finding in ICU patients with COVID-19. Although viremia was not associated with extra pulmonary organ failure it was more common in patients who did not survive to 30 days after ICU admission.Trial registration: ClinicalTrials NCT04316884.", "doi": "10.1038/s41598-021-86500-y", "pmid": "33785784", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-86500-y"}, {"db": "pmc", "key": "PMC8010103"}, {"db": "ClinicalTrials.gov", "key": "NCT04316884"}], "notes": [], "created": "2021-04-09T16:26:36.852Z", "modified": "2021-06-11T14:14:53.671Z"}, {"entity": "publication", "iuid": "41e5af559a954cca92916b7c5903d08f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41e5af559a954cca92916b7c5903d08f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41e5af559a954cca92916b7c5903d08f"}}, "title": "Digital social entrepreneurship: the N-Helix response to stakeholders' COVID-19 needs.", "authors": [{"family": "Ib\u00e1\u00f1ez", "given": "Mar\u00eda J", "initials": "MJ"}, {"family": "Guerrero", "given": "Maribel", "initials": "M"}, {"family": "Y\u00e1\u00f1ez-Vald\u00e9s", "given": "Claudia", "initials": "C"}, {"family": "Barros-Celume", "given": "Sebasti\u00e1n", "initials": "S"}], "type": "journal article", "published": "2021-03-30", "journal": {"title": "J Technol Transf", "issn": "0892-9912", "volume": null, "issue": null, "pages": "1-24", "issn-l": null}, "abstract": "This study explores the emergence of a new entrepreneurship phenomenon (digital social entrepreneurship) as a result of the collaboration among many agents (N-Helix), given the government's limited capacity to respond to the stakeholders' needs satisfaction related to an exogenous event (e.g., the COVID-19 pandemic). Our theory development is based on three ongoing academic debates related to (a) the unrepresentativeness of the stakeholder theory in entrepreneurship research; (b) the emergence of digital social entrepreneurship (DSE) as a bridge between stakeholders' needs, socio-economic actors, and digital-social initiatives; and (c) the role of N-Helix collaborations to facilitate the emergence of global knowledge-intensive initiatives and the rapid adoptions of open innovations. Our results support our assumptions about the positive mediation effect of DSE in the relationship between N-Helix collaborations and stakeholders' satisfaction. Notably, results show how pandemic has intensified these relationships and how DSE in N-Helix collaborations can generate social impacts globally. Some implications for policy-makers have emerged from our results that should be considered during/post-COVID-19 pandemic.", "doi": "10.1007/s10961-021-09855-4", "pmid": "33814697", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "9855"}, {"db": "pmc", "key": "PMC8007451"}], "notes": [], "created": "2021-04-06T10:05:31.670Z", "modified": "2021-04-06T10:05:31.694Z"}, {"entity": "publication", "iuid": "23537200a18d4363813fcb1d9bc99ad4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23537200a18d4363813fcb1d9bc99ad4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23537200a18d4363813fcb1d9bc99ad4"}}, "title": "A patient satisfaction survey and educational package to improve the care of people hospitalised with COVID-19: an observational study, Liverpool, UK", "authors": [{"family": "Ahmed", "given": "Muhammad Shamsher", "initials": "MS"}, {"family": "Hicks", "given": "Scott Rory", "initials": "SR"}, {"family": "Watson", "given": "Rebecca", "initials": "R"}, {"family": "Ahmed", "given": "Rajia Akter", "initials": "RA"}, {"family": "Jones", "given": "Lewis", "initials": "L"}, {"family": "Vaselli", "given": "Marcella", "initials": "M"}, {"family": "Wu", "given": "Meng San", "initials": "MS"}, {"family": "Hayat", "given": "Fatima", "initials": "F"}, {"family": "Ratcliffe", "given": "Libuse", "initials": "L"}, {"family": "McKenna", "given": "Mark", "initials": "M"}, {"family": "Hine", "given": "Paul", "initials": "P"}, {"family": "Defres", "given": "Sylviane", "initials": "S"}, {"family": "Wingfield", "given": "Tom", "initials": "T"}], "type": "posted-content", "published": "2021-03-30", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.23.21253630", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-03-31T08:19:04.466Z", "modified": "2021-04-07T10:24:37.804Z"}, {"entity": "publication", "iuid": "9ccdc15ea88a46639b096f5aaabaf24f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ccdc15ea88a46639b096f5aaabaf24f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ccdc15ea88a46639b096f5aaabaf24f"}}, "title": "Sexual health (excluding reproductive health, intimate partner violence and gender-based violence) and COVID-19: a scoping review.", "authors": [{"family": "Kumar", "given": "Navin", "initials": "N"}, {"family": "Janmohamed", "given": "Kamila", "initials": "K"}, {"family": "Nyhan", "given": "Kate", "initials": "K"}, {"family": "Forastiere", "given": "Laura", "initials": "L"}, {"family": "Zhang", "given": "Wei-Hong", "initials": "WH"}, {"family": "K\u00e5gesten", "given": "Anna", "initials": "A"}, {"family": "Uhlich", "given": "Maximiliane", "initials": "M"}, {"family": "Sarpong Frimpong", "given": "Afia", "initials": "A"}, {"family": "Van de Velde", "given": "Sarah", "initials": "S"}, {"family": "Francis", "given": "Joel M", "initials": "JM"}, {"family": "Erausquin", "given": "Jennifer Toller", "initials": "JT"}, {"family": "Larrson", "given": "Elin", "initials": "E"}, {"family": "Callander", "given": "Deton", "initials": "D"}, {"family": "Scott", "given": "John", "initials": "J"}, {"family": "Minichiello", "given": "Victor", "initials": "V"}, {"family": "Tucker", "given": "Joseph", "initials": "J"}], "type": "journal article", "published": "2021-03-29", "journal": {"title": "Sex Transm Infect", "issn": "1472-3263", "volume": null, "issue": null, "issn-l": "1368-4973"}, "abstract": "The COVID-19 pandemic has exposed and exacerbated existing socioeconomic and health disparities, including disparities in sexual health and well-being. While there have been several reviews published on COVID-19 and population health disparities generally-including some with attention to HIV-none has focused on sexual health (ie, STI care, female sexual health, sexual behaviour). We have conducted a scoping review focused on sexual health (excluding reproductive health (RH), intimate partner violence (IPV) and gender-based violence (GBV)) in the COVID-19 era, examining sexual behaviours and sexual health outcomes.\n\nA scoping review, compiling both peer-reviewed and grey literature, focused on sexual health (excluding RH, IPV and GBV) and COVID-19 was conducted on 15 September 2020. Multiple bibliographical databases were searched. Study selection conformed to Joanna Briggs Institute (JBI) Reviewers' Manual 2015 Methodology for JBI Scoping Reviews. We only included English-language original studies.\n\nWe found that men who have sex with men may be moving back toward pre-pandemic levels of sexual activity, and that STI and HIV testing rates seem to have decreased. There was minimal focus on outcomes such as the economic impact on sexual health (excluding RH, IPV and GBV) and STI care, especially STI care of marginalised populations. In terms of population groups, there was limited focus on sex workers or on women, especially women's sexual behaviour and mental health. We noticed limited use of qualitative techniques. Very few studies were in low/middle-income countries (LMICs).\n\nSexual health research is critical during a global infectious disease pandemic and our review of studies suggested notable research gaps. Researchers can focus efforts on LMICs and under-researched topics within sexual health and explore the use of qualitative techniques and interventions where appropriate.", "doi": "10.1136/sextrans-2020-054896", "pmid": "33782145", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "sextrans-2020-054896"}], "notes": [], "created": "2021-03-31T08:14:48.949Z", "modified": "2021-04-23T16:12:40.581Z"}, {"entity": "publication", "iuid": "bdfac6c6a319440bb5a4d00d0851a5fe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bdfac6c6a319440bb5a4d00d0851a5fe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bdfac6c6a319440bb5a4d00d0851a5fe"}}, "title": "Key considerations on the potential impacts of the COVID-19 pandemic on antimicrobial resistance research and surveillance.", "authors": [{"family": "Rodr\u00edguez-Ba\u00f1o", "given": "Jes\u00fas", "initials": "J"}, {"family": "Rossolini", "given": "Gian Maria", "initials": "GM"}, {"family": "Schultsz", "given": "Constance", "initials": "C"}, {"family": "Tacconelli", "given": "Evelina", "initials": "E"}, {"family": "Murthy", "given": "Srinivas", "initials": "S"}, {"family": "Ohmagari", "given": "Norio", "initials": "N"}, {"family": "Holmes", "given": "Alison", "initials": "A"}, {"family": "Bachmann", "given": "Till", "initials": "T"}, {"family": "Goossens", "given": "Herman", "initials": "H"}, {"family": "Canton", "given": "Rafael", "initials": "R"}, {"family": "Roberts", "given": "Adam P", "initials": "AP"}, {"family": "Henriques-Normark", "given": "Birgitta", "initials": "B"}, {"family": "Clancy", "given": "Cornelius J", "initials": "CJ"}, {"family": "Huttner", "given": "Benedikt", "initials": "B"}, {"family": "Fagerstedt", "given": "Patriq", "initials": "P"}, {"family": "Lahiri", "given": "Shawon", "initials": "S"}, {"family": "Kaushic", "given": "Charu", "initials": "C"}, {"family": "Hoffman", "given": "Steven J", "initials": "SJ"}, {"family": "Warren", "given": "Margo", "initials": "M"}, {"family": "Zoubiane", "given": "Ghada", "initials": "G"}, {"family": "Essack", "given": "Sabiha", "initials": "S"}, {"family": "Laxminarayan", "given": "Ramanan", "initials": "R"}, {"family": "Plant", "given": "Laura", "initials": "L"}], "type": "journal article", "published": "2021-03-27", "journal": {"title": "Trans R Soc Trop Med Hyg", "issn": "1878-3503", "volume": null, "issue": null, "issn-l": null}, "abstract": "Antibiotic use in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients during the COVID-19 pandemic has exceeded the incidence of bacterial coinfections and secondary infections, suggesting inappropriate and excessive prescribing. Even in settings with established antimicrobial stewardship (AMS) programmes, there were weaknesses exposed regarding appropriate antibiotic use in the context of the pandemic. Moreover, antimicrobial resistance (AMR) surveillance and AMS have been deprioritised with diversion of health system resources to the pandemic response. This experience highlights deficiencies in AMR containment and mitigation strategies that require urgent attention from clinical and scientific communities. These include the need to implement diagnostic stewardship to assess the global incidence of coinfections and secondary infections in COVID-19 patients, including those by multidrug-resistant pathogens, to identify patients most likely to benefit from antibiotic treatment and identify when antibiotics can be safely withheld, de-escalated or discontinued. Long-term global surveillance of clinical and societal antibiotic use and resistance trends is required to prepare for subsequent changes in AMR epidemiology, while ensuring uninterrupted supply chains and preventing drug shortages and stock outs. These interventions present implementation challenges in resource-constrained settings, making a case for implementation research on AMR. Knowledge and support for these practices will come from internationally coordinated, targeted research on AMR, supporting the preparation for future challenges from emerging AMR in the context of the current COVID-19 pandemic or future pandemics.", "doi": "10.1093/trstmh/trab048", "pmid": "33772597", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "6195536"}], "notes": [], "created": "2021-03-29T09:28:58.612Z", "modified": "2021-03-29T09:28:58.622Z"}, {"entity": "publication", "iuid": "b41b8b76a4534c3e81ce1b931d5bd041", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b41b8b76a4534c3e81ce1b931d5bd041.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b41b8b76a4534c3e81ce1b931d5bd041"}}, "title": "What must be done to tackle vaccine hesitancy and barriers to COVID-19 vaccination in migrants?", "authors": [{"family": "Crawshaw", "given": "Alison F", "initials": "AF"}, {"family": "Deal", "given": "Anna", "initials": "A"}, {"family": "Rustage", "given": "Kieran", "initials": "K"}, {"family": "Forster", "given": "Alice S", "initials": "AS"}, {"family": "Campos-Matos", "given": "Ines", "initials": "I"}, {"family": "Vandrevala", "given": "Tushna", "initials": "T"}, {"family": "W\u00fcrz", "given": "Andrea", "initials": "A"}, {"family": "Pharris", "given": "Anastasia", "initials": "A"}, {"family": "Suk", "given": "Jonathan", "initials": "J"}, {"family": "Kinsman", "given": "John", "initials": "J"}, {"family": "Deogan", "given": "Charlotte", "initials": "C"}, {"family": "Miller", "given": "Anna", "initials": "A"}, {"family": "Declich", "given": "Silvia", "initials": "S"}, {"family": "Greenaway", "given": "Chris", "initials": "C"}, {"family": "Noori", "given": "Teymur", "initials": "T"}, {"family": "Hargreaves", "given": "Sally", "initials": "S"}], "type": "journal article", "published": "2021-03-26", "journal": {"title": "J Travel Med", "issn": "1708-8305", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1093/jtm/taab048", "pmid": "33772312", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6189154"}], "notes": [], "created": "2021-03-29T09:27:31.563Z", "modified": "2021-06-18T15:45:53.420Z"}, {"entity": "publication", "iuid": "6fa79dbdcf4a48edaf5018baab0e0286", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6fa79dbdcf4a48edaf5018baab0e0286.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6fa79dbdcf4a48edaf5018baab0e0286"}}, "title": "The COVID-19 Epidemic: Management and Outcomes of Hemodialysis and Peritoneal Dialysis Patients in Stockholm, Sweden.", "authors": [{"family": "Smolander", "given": "Jessica", "initials": "J"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}], "type": "news", "published": "2021-03-26", "journal": {"title": "Kidney Blood Press Res", "issn": "1423-0143", "volume": "46", "issue": "2", "pages": "1-7", "issn-l": null}, "abstract": "The COVID-19 outbreak has been associated with a high morbidity, mortality, and a risk of long-term sequelae, and patients with severe COVID-19 are at increased risk of acute kidney injury. CKD patients are at high risk of being exposed to COVID-19 and suffer complications and poor outcome. In Sweden, mitigation strategies did not include lockdown. During March-April of 2020, wide-spread infection occurred in Stockholm.\n\nManagement and outcomes in forty hemodialysis (HD) patients and 4 peritoneal dialysis (PD) patients, with symptomatic COVID-19 in greater Stockholm during March and April of 2020 are reported.\n\nTwenty-four HD patients (60%) required medical care and hospitalization, whereas 16 patients (40%) were treated at home. Nine patients died (mortality rate of 22.5%), of whom 8 were men. The median age in non-survivors (78 years) was significantly higher than in survivors (p = 0.003). The median time in dialysis (11.5 years) was also significantly longer in non-survivors (p = 0.01). C-reactive protein (CRP) at diagnosis in 7 of non-survivors (median 213 mg/L, range 86-329 mg/L) was significantly higher than the CRP in 25 survivors (median 87 mg/L, range 1-328 mg/L) (p = 0.0003). Maximum CRP also indicated poorer outcome among hospitalized patients (p = 0.0004). The gender imbalance was striking with only men dying apart from 1 elderly woman. Only 4 PD patients were hospitalized with symptomatic COVID-19. One patient died, 2 were discharged, and 1 was treated at the intensive care unit and survived.\n\nHD patients >70 years were reported with longer dialysis vintage, higher CRP, and males were at an increased risk of dying from COVID-19, whereas those <70 years seemed to have a milder disease. Mitigation strategies to reduce rates of infection in high-risk populations remain essential. Follow-up focusing on long-term prognosis for extrapulmonary manifestations is likely to be important also in dialysis patients.", "doi": "10.1159/000514268", "pmid": "33774645", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "000514268"}], "notes": [], "created": "2021-03-29T09:30:38.838Z", "modified": "2021-04-28T18:08:47.789Z"}, {"entity": "publication", "iuid": "76bcc47259e5489c80a8c7107c73db6d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76bcc47259e5489c80a8c7107c73db6d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76bcc47259e5489c80a8c7107c73db6d"}}, "title": "Pregnancy and risk of COVID-19", "authors": [{"family": "Magnus", "given": "Maria C", "initials": "MC"}, {"family": "Oakley", "given": "Laura", "initials": "L"}, {"family": "K. Gjessing", "given": "H\u00e5kon", "initials": "H"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}, {"family": "Engjom", "given": "Hilde M", "initials": "HM"}, {"family": "Macsali", "given": "Ferenc", "initials": "F"}, {"family": "Juliusson", "given": "Petur B", "initials": "PB"}, {"family": "Andersen", "given": "Anne Marie Nybo", "initials": "AMN"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}], "type": "posted-content", "published": "2021-03-26", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.22.21254090", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-03-31T08:17:27.439Z", "modified": "2021-06-09T19:20:53.081Z"}, {"entity": "publication", "iuid": "0be63deaa6a04dbd94018b9288d6658a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0be63deaa6a04dbd94018b9288d6658a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0be63deaa6a04dbd94018b9288d6658a"}}, "title": "Molecular detection of SARS-CoV-2 being challenged by virus variation and asymptomatic infection.", "authors": [{"family": "Jiang", "given": "Congshan", "initials": "C"}, {"family": "Li", "given": "Xiaowei", "initials": "X"}, {"family": "Ge", "given": "Changrong", "initials": "C"}, {"family": "Ding", "given": "Yuanyuan", "initials": "Y"}, {"family": "Zhang", "given": "Tao", "initials": "T"}, {"family": "Cao", "given": "Shuai", "initials": "S"}, {"family": "Meng", "given": "Liesu", "initials": "L"}, {"family": "Lu", "given": "Shemin", "initials": "S"}], "type": "journal article", "published": "2021-03-26", "journal": {"title": "J Pharm Anal", "issn": "2214-0883", "volume": null, "issue": null, "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) has been a pandemic for more than a year. With the expanding second wave of pandemic in winter, the continuous evolution of SARS-CoV-2 has brought new issues, including the significance of virus mutations in infection and the detection of asymptomatic infection. In this review, we firstly introduced several major SARS-CoV-2 mutations since the COVID-19 outbreak and then mentioned the widely used molecular detection techniques to diagnose COVID-19, primarily focusing on their strengths and limitations. We further discussed the effects of viral genetic variation and asymptomatic infection on the molecular detection of SARS-CoV-2 infection. The review finally summarized useful insights into the molecular diagnosis of COVID-19 under the special situation challenging by virus mutation and asymptomatic infection.", "doi": "10.1016/j.jpha.2021.03.006", "pmid": "33815862", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2095-1779(21)00026-5"}, {"db": "pmc", "key": "PMC7997641"}], "notes": [], "created": "2021-04-06T10:04:49.143Z", "modified": "2021-04-06T10:04:49.166Z"}, {"entity": "publication", "iuid": "ff8aebe28e134ff58876ef8b0f4c1f82", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff8aebe28e134ff58876ef8b0f4c1f82.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff8aebe28e134ff58876ef8b0f4c1f82"}}, "title": "Impact of the COVID-19 Pandemic on Antimicrobial Resistance (AMR) Surveillance, Prevention and Control: A Global Survey", "authors": [{"family": "Tomczyk", "given": "Sara", "initials": "S"}, {"family": "Taylor", "given": "Angelina", "initials": "A"}, {"family": "Brown", "given": "Allison", "initials": "A"}, {"family": "Kraker", "given": "Marlieke de", "initials": "Md"}, {"family": "Eckmanns", "given": "Tim", "initials": "T"}, {"family": "El-Saed", "given": "Aiman", "initials": "A"}, {"family": "Alshamrani", "given": "Majid", "initials": "M"}, {"family": "Hendriksen", "given": "Rene", "initials": "R"}, {"family": "Jacob", "given": "Megan", "initials": "M"}, {"family": "L\u00f6fmark", "given": "Sonja", "initials": "S"}, {"family": "Perovic", "given": "Olga", "initials": "O"}, {"family": "Shetty", "given": "Nandini", "initials": "N"}, {"family": "Sievert", "given": "Dawn", "initials": "D"}, {"family": "Smith", "given": "Rachel", "initials": "R"}, {"family": "Stelling", "given": "John", "initials": "J"}, {"family": "Thakur", "given": "Siddhartha", "initials": "S"}, {"family": "Tornimbene", "given": "Barbara", "initials": "B"}, {"family": "Vietor", "given": "Ann Christin", "initials": "AC"}, {"family": "Eremin", "given": "Sergey", "initials": "S"}], "type": "posted-content", "published": "2021-03-26", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.24.21253807", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-03-31T08:21:46.157Z", "modified": "2021-04-07T10:24:52.698Z"}, {"entity": "publication", "iuid": "5cb6103efe2c4cde859dd9170a6cc94d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5cb6103efe2c4cde859dd9170a6cc94d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5cb6103efe2c4cde859dd9170a6cc94d"}}, "title": "Ultra-fast proteomics with Scanning SWATH.", "authors": [{"family": "Messner", "given": "Christoph B", "initials": "CB"}, {"family": "Demichev", "given": "Vadim", "initials": "V"}, {"family": "Bloomfield", "given": "Nic", "initials": "N"}, {"family": "Yu", "given": "Jason S L", "initials": "JSL"}, {"family": "White", "given": "Matthew", "initials": "M"}, {"family": "Kreidl", "given": "Marco", "initials": "M"}, {"family": "Egger", "given": "Anna-Sophia", "initials": "AS"}, {"family": "Freiwald", "given": "Anja", "initials": "A"}, {"family": "Ivosev", "given": "Gordana", "initials": "G"}, {"family": "Wasim", "given": "Fras", "initials": "F"}, {"family": "Zelezniak", "given": "Aleksej", "initials": "A"}, {"family": "J\u00fcrgens", "given": "Linda", "initials": "L"}, {"family": "Suttorp", "given": "Norbert", "initials": "N"}, {"family": "Sander", "given": "Leif Erik", "initials": "LE"}, {"family": "Kurth", "given": "Florian", "initials": "F"}, {"family": "Lilley", "given": "Kathryn S", "initials": "KS"}, {"family": "M\u00fclleder", "given": "Michael", "initials": "M"}, {"family": "Tate", "given": "Stephen", "initials": "S"}, {"family": "Ralser", "given": "Markus", "initials": "M"}], "type": "journal article", "published": "2021-03-25", "journal": {"title": "Nat Biotechnol", "issn": "1546-1696", "volume": null, "issue": null, "issn-l": null}, "abstract": "Accurate quantification of the proteome remains challenging for large sample series and longitudinal experiments. We report a data-independent acquisition method, Scanning SWATH, that accelerates mass spectrometric (MS) duty cycles, yielding quantitative proteomes in combination with short gradients and high-flow (800 \u00b5l min -1) chromatography. Exploiting a continuous movement of the precursor isolation window to assign precursor masses to tandem mass spectrometry (MS/MS) fragment traces, Scanning SWATH increases precursor identifications by ~70% compared to conventional data-independent acquisition (DIA) methods on 0.5-5-min chromatographic gradients. We demonstrate the application of ultra-fast proteomics in drug mode-of-action screening and plasma proteomics. Scanning SWATH proteomes capture the mode of action of fungistatic azoles and statins. Moreover, we confirm 43 and identify 11 new plasma proteome biomarkers of COVID-19 severity, advancing patient classification and biomarker discovery. Thus, our results demonstrate a substantial acceleration and increased depth in fast proteomic experiments that facilitate proteomic drug screens and clinical studies.", "doi": "10.1038/s41587-021-00860-4", "pmid": "33767396", "labels": {"Category: Proteins": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41587-021-00860-4"}, {"db": "URL", "key": "https://github.com/vdemichev/diann", "description": "Open-source algorithms made available through the DIA\u2013NN software suite"}, {"db": "URL", "key": "http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD023613", "description": "ProteomeXchange PXD023613: data generated for the benchmarks and the drug response screen in yeast"}], "notes": [], "created": "2021-03-29T09:19:46.825Z", "modified": "2021-04-23T16:13:04.586Z"}, {"entity": "publication", "iuid": "bf78c207136341c2905e9e118563642a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf78c207136341c2905e9e118563642a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf78c207136341c2905e9e118563642a"}}, "title": "Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts.", "authors": [{"family": "Molteni", "given": "Erika", "initials": "E", "orcid": "0000-0001-7773-8140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9aed1fbe444b48d4bfacb12050953c8e.json"}}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Magee", "given": "Laura A", "initials": "LA"}, {"family": "Murray", "given": "Benjamin", "initials": "B"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Gomez", "given": "Maria F", "initials": "MF"}, {"family": "Tsereteli", "given": "Neli", "initials": "N"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Brownstein", "given": "John S", "initials": "JS"}, {"family": "Davies", "given": "Richard", "initials": "R"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Spector", "given": "Tim D", "initials": "TD"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "Modat", "given": "Marc", "initials": "M"}], "type": "journal article", "published": "2021-03-25", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "6928"}, "abstract": "We tested whether pregnant and non-pregnant women differ in COVID-19 symptom profile and severity, and we extended previous investigations on hospitalized pregnant women to those who did not require hospitalization. Two female community-based cohorts (18-44 years) provided longitudinal (smartphone application, N = 1,170,315, n = 79 pregnant tested positive) and cross-sectional (web-based survey, N = 1,344,966, n = 134 pregnant tested positive) data, prospectively collected through self-participatory citizen surveillance in UK, Sweden and USA. Pregnant and non-pregnant were compared for frequencies of events, including SARS-CoV-2 testing, symptoms and hospitalization rates. Multivariable regression was used to investigate symptoms severity and comorbidity effects. Pregnant and non-pregnant women positive for SARS-CoV-2 infection were not different in syndromic severity, except for gastrointestinal symptoms. Pregnant were more likely to have received testing, despite reporting fewer symptoms. Pre-existing lung disease was most closely associated with syndromic severity in pregnant hospitalized. Heart and kidney diseases and diabetes increased risk. The most frequent symptoms among non-hospitalized women were anosmia [63% pregnant, 92% non-pregnant] and headache [72%, 62%]. Cardiopulmonary symptoms, including persistent cough [80%] and chest pain [73%], were more frequent among pregnant who were hospitalized. Consistent with observations in non-pregnant populations, lung disease and diabetes were associated with increased risk of more severe SARS-CoV-2 infection during pregnancy.", "doi": "10.1038/s41598-021-86452-3", "pmid": "33767292", "labels": {"Funder: Hj\u00e4rt-Lungfonden": null, "Category: Public Health": null, "Type: Journal article": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC7994587"}, {"db": "pii", "key": "10.1038/s41598-021-86452-3"}], "notes": [], "created": "2021-03-29T09:18:57.274Z", "modified": "2023-06-19T15:07:30.522Z"}, {"entity": "publication", "iuid": "0d40115030b14f5a86f99e3945d1643a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d40115030b14f5a86f99e3945d1643a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d40115030b14f5a86f99e3945d1643a"}}, "title": "Site-Specific O-Glycosylation Analysis of SARS-CoV-2 Spike Protein Produced in Insect and Human Cells.", "authors": [{"family": "Bagdonaite", "given": "Ieva", "initials": "I"}, {"family": "Thompson", "given": "Andrew J", "initials": "AJ"}, {"family": "Wang", "given": "Xiaoning", "initials": "X"}, {"family": "S\u00f8gaard", "given": "Max", "initials": "M"}, {"family": "Fougeroux", "given": "Cyrielle", "initials": "C"}, {"family": "Frank", "given": "Martin", "initials": "M"}, {"family": "Diedrich", "given": "Jolene K", "initials": "JK"}, {"family": "Yates", "given": "John R", "initials": "JR"}, {"family": "Salanti", "given": "Ali", "initials": "A"}, {"family": "Vakhrushev", "given": "Sergey Y", "initials": "SY"}, {"family": "Paulson", "given": "James C", "initials": "JC"}, {"family": "Wandall", "given": "Hans H", "initials": "HH"}], "type": "journal article", "published": "2021-03-25", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "4", "issn-l": "1999-4915"}, "abstract": "Enveloped viruses hijack not only the host translation processes, but also its glycosylation machinery, and to a variable extent cover viral surface proteins with tolerogenic host-like structures. SARS-CoV-2 surface protein S presents as a trimer on the viral surface and is covered by a dense shield of N-linked glycans, and a few O-glycosites have been reported. The location of O-glycans is controlled by a large family of initiating enzymes with variable expression in cells and tissues and hence is difficult to predict. Here, we used our well-established O-glycoproteomic workflows to map the precise positions of O-linked glycosylation sites on three different entities of protein S-insect cell or human cell-produced ectodomains, or insect cell derived receptor binding domain (RBD). In total 25 O-glycosites were identified, with similar patterns in the two ectodomains of different cell origin, and a distinct pattern of the monomeric RBD. Strikingly, 16 out of 25 O-glycosites were located within three amino acids from known N-glycosites. However, O-glycosylation was primarily found on peptides that were unoccupied by N-glycans, and otherwise had low overall occupancy. This suggests possible complementary functions of O-glycans in immune shielding and negligible effects of O-glycosylation on subunit vaccine design for SARS-CoV-2.", "doi": "10.3390/v13040551", "pmid": "33806155", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "v13040551"}], "notes": [], "created": "2021-04-06T10:35:44.200Z", "modified": "2021-04-06T10:35:44.209Z"}, {"entity": "publication", "iuid": "c6c8a24310104994be31f728755aa631", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c6c8a24310104994be31f728755aa631.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c6c8a24310104994be31f728755aa631"}}, "title": "COVID-19 Editorial: Mechanistic Links and Daunting Therapeutic Challenges for Metabolic Diseases One Year after The Beginning of The COVID-19 Pandemic.", "authors": [{"family": "Tessier", "given": "Christopher M", "initials": "CM"}, {"family": "Kokkinos", "given": "Alexander", "initials": "A"}, {"family": "Mingrone", "given": "Geltrude", "initials": "G"}, {"family": "Koliaki", "given": "Chrysi", "initials": "C"}, {"family": "Zierath", "given": "Juleen R", "initials": "JR"}, {"family": "Mantzoros", "given": "Christos S", "initials": "CS"}], "type": "editorial", "published": "2021-03-25", "journal": {"title": "Metabolism", "issn": "1532-8600", "volume": null, "issue": null, "pages": "154769", "issn-l": null}, "abstract": null, "doi": "10.1016/j.metabol.2021.154769", "pmid": "33775648", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0026-0495(21)00069-X"}], "notes": [], "created": "2021-03-30T12:15:01.308Z", "modified": "2021-03-30T12:15:01.324Z"}, {"entity": "publication", "iuid": "e1da34c615124871ae7119f2d1c31ada", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e1da34c615124871ae7119f2d1c31ada.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e1da34c615124871ae7119f2d1c31ada"}}, "title": "A Simple Model for the Total Number of SARS-CoV-2 Infections on a National Level", "authors": [{"family": "Blanco", "given": "N", "initials": "N"}, {"family": "Stafford", "given": "K", "initials": "K"}, {"family": "Lavoie", "given": "M C", "initials": "MC"}, {"family": "Brandenburg", "given": "A", "initials": "A"}, {"family": "G\u00f3rna", "given": "M W", "initials": "MW"}, {"family": "Merski", "given": "M", "initials": "M"}], "type": "journal-article", "published": "2021-03-25", "journal": {"title": "Epidemiol. Infect.", "issn": "0950-2688", "issn-l": null, "volume": null, "issue": null, "pages": "1-25"}, "abstract": null, "doi": "10.1017/s0950268821000649", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.5281/zenodo.4454173", "description": "Raw, original data and fits data set"}], "notes": [], "created": "2021-03-25T14:01:34.383Z", "modified": "2021-06-18T15:40:26.357Z"}, {"entity": "publication", "iuid": "609fc217e83b4e8891e131b5bf0bd9bc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/609fc217e83b4e8891e131b5bf0bd9bc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/609fc217e83b4e8891e131b5bf0bd9bc"}}, "title": "Impact of the COVID-19 pandemic on emergency and elective hip surgeries in Norway.", "authors": [{"family": "Magnusson", "given": "Karin", "initials": "K"}, {"family": "Helgeland", "given": "Jon", "initials": "J"}, {"family": "Gr\u00f8sland", "given": "Mari", "initials": "M"}, {"family": "Telle", "given": "Kjetil", "initials": "K"}], "type": "journal article", "published": "2021-03-24", "journal": {"title": "Acta Orthop", "issn": "1745-3682", "issn-l": null, "volume": null, "issue": null, "pages": "1-5"}, "abstract": "Background and purpose - Many countries implemented strict lockdown policies to control the COVID-19 pandemic during March 2020. The impacts of lockdown policies on joint surgeries are unknown. Therefore, we assessed the effects of COVID-19 pandemic lockdown restrictions on the number of emergency and elective hip joint surgeries, and explored whether these procedures are more/less affected by lockdown restrictions than other hospital care.Patients and methods - In 1,344,355 persons aged \u2265 35 years in the Norwegian emergency preparedness (BEREDT C19) register, we studied the daily number of persons having (1) emergency surgeries due to hip fractures, and (2) electively planned surgeries due to hip osteoarthritis before and after COVID-19 lockdown restrictions were implemented nationally on March 13, 2020, for different age and sex groups. Incidence rate ratios (IRR) reflect the after-lockdown number of surgeries divided by the before-lockdown number of surgeries.Results - After-lockdown elective hip surgeries comprised one-third the number of before-lockdown (IRR \u223c0.3), which is a greater drop than that seen in all-cause elective hospital care (IRR \u223c0.6). Men aged 35-69 had half the number of emergency hip fracture surgeries (IRR \u223c0.6), whereas women aged \u2265 70 had the same number of emergency hip fracture surgeries after lockdown (IRR \u223c1). Only women aged 35-69 and men aged \u2265 70 had emergency hip fracture surgery rates after lockdown comparable to what may be expected based on analyses of all-cause acute care (IRR \u223c0.80)Interpretation - It is important to note for future pandemics management that lockdown restrictions may impact more on scheduled joint surgery than other scheduled hospital care. Lockdown may also impact the number of emergency joint surgeries for men aged \u2265 35 but not those for women aged \u2265 70.", "doi": "10.1080/17453674.2021.1898782", "pmid": "33757405", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-03-25T13:56:55.551Z", "modified": "2021-03-25T13:57:54.036Z"}, {"entity": "publication", "iuid": "dc56fd4c0afb439f9a943617cb5b418a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dc56fd4c0afb439f9a943617cb5b418a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dc56fd4c0afb439f9a943617cb5b418a"}}, "title": "Factors Associated with Emerging and Re-emerging of SARS-CoV-2 Variants", "authors": [{"family": "Spratt", "given": "Austin N", "initials": "AN"}, {"family": "Kannan", "given": "Saathvik R", "initials": "SR"}, {"family": "Woods", "given": "Lucas T", "initials": "LT"}, {"family": "Weisman", "given": "Gary A", "initials": "GA"}, {"family": "Quinn", "given": "Thomas P", "initials": "TP"}, {"family": "Lorson", "given": "Christian L", "initials": "CL"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}, {"family": "Singh", "given": "Kamal", "initials": "K"}], "type": "posted-content", "published": "2021-03-24", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.24.436850", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null}, "xrefs": [], "notes": [], "created": "2021-04-15T18:53:24.322Z", "modified": "2021-04-21T08:36:57.929Z"}, {"entity": "publication", "iuid": "ce949ddad1b34d3cba35a5f617b4f1bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ce949ddad1b34d3cba35a5f617b4f1bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ce949ddad1b34d3cba35a5f617b4f1bf"}}, "title": "Diverse SARS-CoV-2 variants preceded the initial COVID-19 outbreak in Croatia.", "authors": [{"family": "Roki\u0107", "given": "Filip", "initials": "F"}, {"family": "Trgovec-Greif", "given": "Lovro", "initials": "L"}, {"family": "Su\u010di\u0107", "given": "Neven", "initials": "N"}, {"family": "\u010cemelji\u0107", "given": "Noa", "initials": "N"}, {"family": "Grbe\u0161a", "given": "\u0110ur\u0111ica Cekinovi\u0107", "initials": "\u0110C"}, {"family": "Svedru\u017ei\u0107", "given": "\u017deljko", "initials": "\u017d"}, {"family": "Rukavina", "given": "Tomislav", "initials": "T"}, {"family": "Vugrek", "given": "Oliver", "initials": "O"}, {"family": "Jurak", "given": "Igor", "initials": "I"}], "type": "journal article", "published": "2021-03-24", "journal": {"title": "Arch Virol", "issn": "1432-8798", "volume": null, "issue": null, "issn-l": null}, "abstract": "We developed a next-generation SARS-CoV-2 sequencing platform and obtained the first SARS-CoV-2 sequences from patients in Croatia at the beginning of the COVID-19 outbreak in the spring of 2020. Integrating the sequencing and the epidemiological data, we show that patients were infected with different SARS-CoV-2 variants belonging to different clades (mostly G and GH). This result confirms that there was widespread virus transmission early in 2020. Interestingly, we identified a unique mutation resulting in a V13I substitution in Nsp5A, the main viral protease, in a patient who had not received antiviral therapy.", "doi": "10.1007/s00705-021-05029-7", "pmid": "33761008", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00705-021-05029-7"}], "notes": [], "created": "2021-03-25T14:00:14.895Z", "modified": "2021-03-25T14:00:14.918Z"}, {"entity": "publication", "iuid": "1d97075d697d4aafba9f1829a8f000c7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d97075d697d4aafba9f1829a8f000c7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d97075d697d4aafba9f1829a8f000c7"}}, "title": "Challenges and opportunities to end tuberculosis in the COVID-19 era.", "authors": [{"family": "Wingfield", "given": "Tom", "initials": "T"}, {"family": "Karmadwala", "given": "Fatima", "initials": "F"}, {"family": "MacPherson", "given": "Peter", "initials": "P"}, {"family": "Millington", "given": "Kerry A", "initials": "KA"}, {"family": "Walker", "given": "Naomi F", "initials": "NF"}, {"family": "Cuevas", "given": "Luis E", "initials": "LE"}, {"family": "Squire", "given": "S Bertel", "initials": "SB"}], "type": "journal article", "published": "2021-03-24", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "issn-l": "2213-2600", "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/S2213-2600(21)00161-2", "pmid": "33773121", "labels": {"Category: Health": null, "Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(21)00161-2"}], "notes": [], "created": "2021-03-29T09:29:47.710Z", "modified": "2022-02-17T09:34:00.457Z"}, {"entity": "publication", "iuid": "5b6e21b205cd469c8bf809697ef51789", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5b6e21b205cd469c8bf809697ef51789.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5b6e21b205cd469c8bf809697ef51789"}}, "title": "Mental Health, Greenness, and Nature Related Behaviors in the Adult Population of Stockholm County during COVID-19-Related Restrictions.", "authors": [{"family": "L\u00f5hmus", "given": "Mare", "initials": "M"}, {"family": "Stenfors", "given": "Cecilia U D", "initials": "CUD"}, {"family": "Lind", "given": "Tomas", "initials": "T"}, {"family": "Lauber", "given": "Andr\u00e9", "initials": "A"}, {"family": "Georgelis", "given": "Antonios", "initials": "A"}], "type": "journal article", "published": "2021-03-23", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "6", "pages": null}, "abstract": "International data suggest that exposure to nature is beneficial for mental health and well-being. The restrictions related to the COVID-19 pandemic have created a setting that allows us to investigate the importance of greenness exposure on mental health during a period of increased isolation and worry. Based on 2060 responses from an online survey in Stockholm County, Sweden, we investigated: (1) whether the COVID-19 pandemic changed peoples' lifestyle and nature-related habits, and (2) if peoples' mental health differed depending on their exposure to greenness. Neighborhood greenness levels were quantified by using the average normalized difference vegetation index (NDVI) within 50 m, 100 m, 300 m, and 500 m buffers surrounding the participant's place of residence. We found that the number of individuals that reported that they visited natural areas \"often\" was significantly higher during the pandemic than before the pandemic. Higher levels of greenness surrounding one's location of residence were in general associated with higher mental health/well-being and vitality scores, and less symptoms of depression, anxiety, and perceived and cognitive stress, after adjustments for demographic variables and walkability. In conclusion, the results from the present study provided support to the suggestion that contact with nature may be important for mental health in extreme circumstances.", "doi": "10.3390/ijerph18063303", "pmid": "33806787", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "ijerph18063303"}], "notes": [], "created": "2021-04-06T10:33:24.157Z", "modified": "2021-06-18T15:35:59.689Z"}, {"entity": "publication", "iuid": "19d49bc018224174b5c789908cb243f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19d49bc018224174b5c789908cb243f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19d49bc018224174b5c789908cb243f4"}}, "title": "Lifestyle Habits and Mental Health in Light of the Two COVID-19 Pandemic Waves in Sweden, 2020.", "authors": [{"family": "Blom", "given": "Victoria", "initials": "V"}, {"family": "L\u00f6nn", "given": "Amanda", "initials": "A"}, {"family": "Ekblom", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Kallings", "given": "Lena V", "initials": "LV"}, {"family": "V\u00e4is\u00e4nen", "given": "Daniel", "initials": "D"}, {"family": "Hemmingsson", "given": "Erik", "initials": "E"}, {"family": "Andersson", "given": "Gunnar", "initials": "G"}, {"family": "Wallin", "given": "Peter", "initials": "P"}, {"family": "Stenling", "given": "Andreas", "initials": "A"}, {"family": "Ekblom", "given": "\u00d6rjan", "initials": "\u00d6"}, {"family": "Lindwall", "given": "Magnus", "initials": "M"}, {"family": "Salier Eriksson", "given": "Jane", "initials": "J"}, {"family": "Holmlund", "given": "Tobias", "initials": "T"}, {"family": "Ekblom-Bak", "given": "Elin", "initials": "E"}], "type": "journal article", "published": "2021-03-23", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "6", "pages": null}, "abstract": "The COVID-19 pandemic has become a public health emergency of international concern, which may have affected lifestyle habits and mental health. Based on national health profile assessments, this study investigated perceived changes of lifestyle habits in response to the COVID-19 pandemic and associations between perceived lifestyle changes and mental health in Swedish working adults. Among 5599 individuals (50% women, 46.3 years), the majority reported no change (sitting 77%, daily physical activity 71%, exercise 69%, diet 87%, alcohol 90%, and smoking 97%) due to the pandemic. Changes were more pronounced during the first wave (April-June) compared to the second (October-December). Women, individuals <60 years, those with a university degree, white-collar workers, and those with unhealthy lifestyle habits at baseline had higher odds of changing lifestyle habits compared to their counterparts. Negative changes in lifestyle habits and more time in a mentally passive state sitting at home were associated with higher odds of mental ill-health (including health anxiety regarding one's own and relatives' health, generalized anxiety and depression symptoms, and concerns regarding employment and economy). The results emphasize the need to support healthy lifestyle habits to strengthen the resilience in vulnerable groups of individuals to future viral pandemics and prevent health inequalities in society.", "doi": "10.3390/ijerph18063313", "pmid": "33806951", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph18063313"}], "notes": [], "created": "2021-04-06T10:32:29.491Z", "modified": "2021-06-18T15:36:38.808Z"}, {"entity": "publication", "iuid": "47ddf7c0b1374994a86b31d2fb52b9db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47ddf7c0b1374994a86b31d2fb52b9db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47ddf7c0b1374994a86b31d2fb52b9db"}}, "title": "Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation.", "authors": [{"family": "Chioh", "given": "Florence Wj", "initials": "FW"}, {"family": "Fong", "given": "Siew-Wai", "initials": "S"}, {"family": "Young", "given": "Barnaby E", "initials": "BE"}, {"family": "Wu", "given": "Kan-Xing", "initials": "K"}, {"family": "Siau", "given": "Anthony", "initials": "A"}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Chan", "given": "Yi-Hao", "initials": "Y"}, {"family": "Carissimo", "given": "Guillaume", "initials": "G"}, {"family": "Teo", "given": "Louis Ly", "initials": "LL"}, {"family": "Gao", "given": "Fei", "initials": "F"}, {"family": "Tan", "given": "Ru San", "initials": "RS"}, {"family": "Zhong", "given": "Liang", "initials": "L"}, {"family": "Koh", "given": "Angela S", "initials": "AS"}, {"family": "Tan", "given": "Seow-Yen", "initials": "S"}, {"family": "Tambyah", "given": "Paul A", "initials": "PA"}, {"family": "Renia", "given": "Laurent", "initials": "L"}, {"family": "Ng", "given": "Lisa Fp", "initials": "LF"}, {"family": "Lye", "given": "David C", "initials": "DC"}, {"family": "Cheung", "given": "Christine", "initials": "C"}], "type": "journal article", "published": "2021-03-23", "journal": {"title": "Elife", "issn": "2050-084X", "issn-l": null, "volume": "10", "issue": null, "pages": null}, "abstract": "Numerous reports of vascular events after an initial recovery from COVID-19 form our impetus to investigate the impact of COVID-19 on vascular health of recovered patients. We found elevated levels of circulating endothelial cells (CECs), a biomarker of vascular injury, in COVID-19 convalescents compared to healthy controls. In particular, those with pre-existing conditions (e.g., hypertension, diabetes) had more pronounced endothelial activation hallmarks than non-COVID-19 patients with matched cardiovascular risk. Several proinflammatory and activated T lymphocyte-associated cytokines sustained from acute infection to recovery phase, which correlated positively with CEC measures, implicating cytokine-driven endothelial dysfunction. Notably, we found higher frequency of effector T cells in our COVID-19 convalescents compared to healthy controls. The activation markers detected on CECs mapped to counter receptors found primarily on cytotoxic CD8 + T cells, raising the possibility of cytotoxic effector cells targeting activated endothelial cells. Clinical trials in preventive therapy for post-COVID-19 vascular complications may be needed.", "doi": "10.7554/eLife.64909", "pmid": "33752798", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "64909"}], "notes": [], "created": "2021-03-24T06:53:57.063Z", "modified": "2021-07-09T12:41:18.717Z"}, {"entity": "publication", "iuid": "fb10dff4709e4303ba629b04a889cdca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb10dff4709e4303ba629b04a889cdca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb10dff4709e4303ba629b04a889cdca"}}, "title": "Author Correction: COVID-19 vaccine guidance for patients with cancer participating in oncology clinical trials.", "authors": [{"family": "Desai", "given": "Aakash", "initials": "A"}, {"family": "Gainor", "given": "Justin F", "initials": "JF"}, {"family": "Hegde", "given": "Aparna", "initials": "A"}, {"family": "Schram", "given": "Alison M", "initials": "AM"}, {"family": "Curigliano", "given": "Giuseppe", "initials": "G"}, {"family": "Pal", "given": "Sumanta", "initials": "S"}, {"family": "Liu", "given": "Stephen V", "initials": "SV"}, {"family": "Halmos", "given": "Balazs", "initials": "B"}, {"family": "Groisberg", "given": "Roman", "initials": "R"}, {"family": "Grande", "given": "Enrique", "initials": "E"}, {"family": "Dragovich", "given": "Tomislav", "initials": "T"}, {"family": "Matrana", "given": "Marc", "initials": "M"}, {"family": "Agarwal", "given": "Neeraj", "initials": "N"}, {"family": "Chawla", "given": "Sant", "initials": "S"}, {"family": "Kato", "given": "Shumei", "initials": "S"}, {"family": "Morgan", "given": "Gilberto", "initials": "G"}, {"family": "Kasi", "given": "Pashtoon M", "initials": "PM"}, {"family": "Solomon", "given": "Benjamin", "initials": "B"}, {"family": "Loong", "given": "Herbert H", "initials": "HH"}, {"family": "Park", "given": "Haeseong", "initials": "H"}, {"family": "Choueiri", "given": "Toni K", "initials": "TK"}, {"family": "Subbiah", "given": "Ishwaria M", "initials": "IM"}, {"family": "Pemmaraju", "given": "Naveen", "initials": "N"}, {"family": "Subbiah", "given": "Vivek", "initials": "V"}, {"family": "COVID19 and Cancer Clinical Trials Working Group", "given": "", "initials": ""}], "type": "published erratum", "published": "2021-03-23", "journal": {"title": "Nat Rev Clin Oncol", "issn": "1759-4782", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1038/s41571-021-00503-2", "pmid": "33758378", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41571-021-00503-2"}], "notes": [], "created": "2021-03-25T13:59:04.682Z", "modified": "2021-03-25T13:59:21.437Z"}, {"entity": "publication", "iuid": "f701ebff8c074df0a2d724d4d0c577a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f701ebff8c074df0a2d724d4d0c577a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f701ebff8c074df0a2d724d4d0c577a6"}}, "title": "Virus-Induced Changes of the Respiratory Tract Environment Promote Secondary Infections With Streptococcus pneumoniae.", "authors": [{"family": "Sender", "given": "Vicky", "initials": "V"}, {"family": "Hentrich", "given": "Karina", "initials": "K"}, {"family": "Henriques-Normark", "given": "Birgitta", "initials": "B"}], "type": "journal article", "published": "2021-03-22", "journal": {"title": "Front Cell Infect Microbiol", "issn": "2235-2988", "volume": "11", "issue": null, "pages": "643326", "issn-l": null}, "abstract": "Secondary bacterial infections enhance the disease burden of influenza infections substantially. Streptococcus pneumoniae (the pneumococcus) plays a major role in the synergism between bacterial and viral pathogens, which is based on complex interactions between the pathogen and the host immune response. Here, we discuss mechanisms that drive the pathogenesis of a secondary pneumococcal infection after an influenza infection with a focus on how pneumococci senses and adapts to the influenza-modified environment. We briefly summarize what is known regarding secondary bacterial infection in relation to COVID-19 and highlight the need to improve our current strategies to prevent and treat viral bacterial coinfections.", "doi": "10.3389/fcimb.2021.643326", "pmid": "33828999", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8019817"}], "notes": [], "created": "2021-04-09T16:44:47.845Z", "modified": "2021-04-28T18:23:24.262Z"}, {"entity": "publication", "iuid": "8a1b420ce97d49dab7916be3f1fd7515", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a1b420ce97d49dab7916be3f1fd7515.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a1b420ce97d49dab7916be3f1fd7515"}}, "title": "Targeting CX3CR1 Suppresses the Fanconi Anemia DNA Repair Pathway and Synergizes with Platinum.", "authors": [{"family": "Lehto", "given": "Jemina", "initials": "J"}, {"family": "Huguet Ninou", "given": "Anna", "initials": "A"}, {"family": "Chioureas", "given": "Dimitrios", "initials": "D"}, {"family": "Jonkers", "given": "Jos", "initials": "J"}, {"family": "Gustafsson", "given": "Nina M S", "initials": "NMS"}], "type": "journal article", "published": "2021-03-22", "journal": {"title": "Cancers (Basel)", "issn": "2072-6694", "issn-l": null, "volume": "13", "issue": "6", "pages": null}, "abstract": "The C-X3-C motif chemokine receptor 1 (CX3CR1, fractalkine receptor) is associated with neoplastic transformation, inflammation, neurodegenerative diseases and aging, and the small molecule inhibitor KAND567 targeting CX3CR1 (CX3CR1i) is evaluated in clinical trials for acute systemic inflammation upon SARS-CoV-2 infections. Here we identify a hitherto unknown role of CX3CR1 in Fanconi anemia (FA) pathway mediated repair of DNA interstrand crosslinks (ICLs) in replicating cells. FA pathway activation triggers CX3CR1 nuclear localization which facilitates assembly of the key FA protein FANCD2 into foci. Interfering with CX3CR1 function upon ICL-induction results in inability of replicating cells to progress from S phase, replication fork stalling and impaired chromatin recruitment of key FA pathway factors. Consistent with defective FA repair, CX3CR1i results in increased levels of residual cisplatin-DNA adducts and decreased cell survival. Importantly, CX3CR1i synergizes with platinum agents in a nonreversible manner in proliferation assays including platinum resistant models. Taken together, our results reveal an unanticipated interplay between CX3CR1 and the FA pathway and show for the first time that a clinical-phase small molecule inhibitor targeting CX3CR1 might show benefit in improving responses to DNA crosslinking chemotherapeutics.", "doi": "10.3390/cancers13061442", "pmid": "33810010", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "cancers13061442"}], "notes": [], "created": "2021-04-06T10:23:48.973Z", "modified": "2021-04-07T13:23:58.431Z"}, {"entity": "publication", "iuid": "4118c1f7f7d24411a4a599164ed5f37e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4118c1f7f7d24411a4a599164ed5f37e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4118c1f7f7d24411a4a599164ed5f37e"}}, "title": "Risk of severe allergic reactions to COVID-19 vaccines among patients with allergic skin diseases - practical recommendations. A position statement of ETFAD with external experts.", "authors": [{"family": "Ring", "given": "J", "initials": "J"}, {"family": "Worm", "given": "M", "initials": "M"}, {"family": "Wollenberg", "given": "A", "initials": "A"}, {"family": "Thyssen", "given": "J P", "initials": "JP"}, {"family": "Jakob", "given": "T", "initials": "T"}, {"family": "Klimek", "given": "L", "initials": "L"}, {"family": "Bangert", "given": "C", "initials": "C"}, {"family": "Barbarot", "given": "S", "initials": "S"}, {"family": "Bieber", "given": "T", "initials": "T"}, {"family": "de Bruin-Weller", "given": "M S", "initials": "MS"}, {"family": "Chernyshov", "given": "P V", "initials": "PV"}, {"family": "Christen-Zaech", "given": "S", "initials": "S"}, {"family": "Cork", "given": "M", "initials": "M"}, {"family": "Darsow", "given": "U", "initials": "U"}, {"family": "Flohr", "given": "C", "initials": "C"}, {"family": "F\u00f6lster-Holst", "given": "R", "initials": "R"}, {"family": "Gelmetti", "given": "C", "initials": "C"}, {"family": "Gieler", "given": "U", "initials": "U"}, {"family": "Gutermuth", "given": "J", "initials": "J"}, {"family": "Heratizadeh", "given": "A", "initials": "A"}, {"family": "Hijnen", "given": "D J", "initials": "DJ"}, {"family": "von Kobyletzki", "given": "L B", "initials": "LB"}, {"family": "Kunz", "given": "B", "initials": "B"}, {"family": "Paul", "given": "C", "initials": "C"}, {"family": "Seneschal", "given": "Julien", "initials": "J"}, {"family": "Simon", "given": "D", "initials": "D"}, {"family": "Spuls", "given": "P I", "initials": "PI"}, {"family": "Stalder", "given": "J F", "initials": "JF"}, {"family": "Svensson", "given": "A", "initials": "A"}, {"family": "Szalai", "given": "Z", "initials": "Z"}, {"family": "Taieb", "given": "A", "initials": "A"}, {"family": "Torrelo", "given": "A", "initials": "A"}, {"family": "Trzeciak", "given": "M", "initials": "M"}, {"family": "Werfel", "given": "T", "initials": "T"}, {"family": "Weidinger", "given": "S", "initials": "S"}, {"family": "Deleuran", "given": "M", "initials": "M"}], "type": "letter", "published": "2021-03-22", "journal": {"title": "J Eur Acad Dermatol Venereol", "issn": "1468-3083", "volume": null, "issue": null, "issn-l": null}, "abstract": "Since the introduction of active vaccination against SARS-CoV-2 infection, there has been a debate about the risk of developing severe allergic or anaphylactic reactions among individuals with a history of allergy. Indeed, rare cases of severe allergic reactions have been reported in the United Kingdom and North America. By february 2021 a rate of 4,5 severe allergic reactions occurred among 1 million patients vaccinated with the mRNA-based COVID-19 vaccines, which is higher than the generally expected rate of severe allergic reactions to vaccinations of around 1 in 1 million.", "doi": "10.1111/jdv.17237", "pmid": "33752263", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-03-24T06:53:28.426Z", "modified": "2021-03-24T06:53:28.438Z"}, {"entity": "publication", "iuid": "46adafc19dc74c4d9319e7815d83a39b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46adafc19dc74c4d9319e7815d83a39b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46adafc19dc74c4d9319e7815d83a39b"}}, "title": "Measurement Invariance of the Drivers of COVID-19 Vaccination Acceptance Scale: Comparison between Taiwanese and Mainland Chinese-Speaking Populations.", "authors": [{"family": "Yeh", "given": "Ya-Chin", "initials": "Y"}, {"family": "Chen", "given": "I-Hua", "initials": "I"}, {"family": "Ahorsu", "given": "Daniel K", "initials": "DK"}, {"family": "Ko", "given": "Nai-Ying", "initials": "N"}, {"family": "Chen", "given": "Kuan-Lin", "initials": "K"}, {"family": "Li", "given": "Ping-Chia", "initials": "P"}, {"family": "Yen", "given": "Cheng-Fang", "initials": "C"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-03-22", "journal": {"title": "Vaccines", "issn": "2076-393X", "issn-l": null, "volume": "9", "issue": "3", "pages": null}, "abstract": "The impacts of novel coronavirus disease-2019 (COVID-19) on human life continue to be serious. To control the spread of COVID-19, the production of effective vaccines is likely to be one of the best solutions. However, vaccination hesitancy may decrease individuals' willingness to get vaccinated. The Drivers of COVID-19 Vaccination Acceptance Scale (DrVac-COVID19S) was recently developed to help healthcare professionals and researchers better understand vaccination acceptance. The present study examined whether DrVac-COVID19S is measurement invariant across different subgroups (Taiwanese vs. mainland Chinese university students; males vs. females; and health-related program majors vs. non-health-related program majors). Taiwanese ( n = 761; mean age = 25.51 years; standard deviation (SD) = 6.42; 63.5% females) and mainland Chinese university students (n = 3145; mean age = 20.72 years; SD = 2.06; 50.2% females) were recruited using an online survey between 5 January and 21 February 2021. Factor structure and measurement invariance of the two DrVac-COVID19S scales (nine-item and 12-item) were tested using confirmatory factor analysis (CFA). The findings indicated that the DrVac-COVID19S had a four-factor structure and was measurement invariant across the subgroups. The DrVac-COVID19S's four-factor structure was supported by the CFA results is a practical and valid instrument to quickly capture university students' willingness to get COVID-19 vaccination. Moreover, the DrVac-COVID19S can be used to compare university students' underlying reasons to get COVID-19 vaccination among different subgroups.", "doi": "10.3390/vaccines9030297", "pmid": "33810036", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "vaccines9030297"}], "notes": [], "created": "2021-04-06T10:23:00.038Z", "modified": "2021-06-18T15:34:51.780Z"}, {"entity": "publication", "iuid": "8e9da1eddbce4edda487f0a7a41c34f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e9da1eddbce4edda487f0a7a41c34f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e9da1eddbce4edda487f0a7a41c34f7"}}, "title": "Antibody kinetics and clinical course of COVID-19 a prospective observational study.", "authors": [{"family": "Bl\u00e4ckberg", "given": "Anna", "initials": "A"}, {"family": "Fernstr\u00f6m", "given": "Nils", "initials": "N"}, {"family": "Sarbrant", "given": "Emma", "initials": "E"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}, {"family": "Sunnerhagen", "given": "Torgny", "initials": "T"}], "type": "journal article", "published": "2021-03-22", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "3", "pages": "e0248918", "issn-l": "1932-6203"}, "abstract": "Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19.\n\nA prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over time in patients with COVID-19. Possible associations between antibody titers and outcome were analyzed.\n\nForty patients with COVID-19, hospitalized at Sk\u00e5ne University hospital, Sweden, between April and June 2020 were included. IgG antibody responses were detected for all patients with the highest levels four weeks after COVID-19 diagnosis. Levels of IgA were generally higher at diagnosis and decreased towards baseline 4 weeks after confirmed COVID-19. Patients with severe COVID-19 had higher levels of antibodies directed against SARS-CoV-2 spike protein compared with patients with mild disease.\n\nIgG and IgA antibodies towards the spike protein follow different kinetics during COVID-19 and patients with severe disease develop higher antibody levels.", "doi": "10.1371/journal.pone.0248918", "pmid": "33750984", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-01958"}], "notes": [], "created": "2021-03-24T06:57:06.356Z", "modified": "2021-03-24T06:57:06.366Z"}, {"entity": "publication", "iuid": "901e54458cd04c57bd0479eaba9f68ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/901e54458cd04c57bd0479eaba9f68ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/901e54458cd04c57bd0479eaba9f68ca"}}, "title": "Acute kidney injury and mortality risk in older adults with COVID-19.", "authors": [{"family": "Xu", "given": "Hong", "initials": "H"}, {"family": "Garcia-Ptacek", "given": "Sara", "initials": "S"}, {"family": "Annetorp", "given": "Martin", "initials": "M"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Cederholm", "given": "Tommy", "initials": "T"}, {"family": "Johnson", "given": "Peter", "initials": "P"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Metzner", "given": "Carina", "initials": "C"}, {"family": "Religa", "given": "Dorota", "initials": "D"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-03-22", "journal": {"title": "J Nephrol", "issn": "1724-6059", "volume": null, "issue": null, "issn-l": null}, "abstract": "Research regarding COVID-19 and acute kidney injury (AKI) in older adults is scarce. We evaluated risk factors and outcomes of AKI in hospitalized older adults with and without COVID-19.\n\nObservational study of patients admitted to two geriatric clinics in Stockholm from March 1st to June 15th, 2020. The difference in incidence, risk factors and adverse outcomes for AKI between patients with or without COVID-19 were examined. Odds ratios (OR) for the risk of AKI and in-hospital death were obtained from logistic regression.\n\nThree hundred-sixteen older patients were hospitalized for COVID-19 and 876 patients for non-COVID-19 diagnoses. AKI occurred in 92 (29%) patients with COVID-19 vs. 159 (18%) without COVID-19. The odds for developing AKI were higher in patients with COVID-19 (adjusted OR, 1.70; 95% confidence interval [CI] 1.04-2.76), low baseline kidney function as depicted by estimated glomerular filtration rate (eGFR) [4.19 (2.48-7.05), for eGFR 30 to < 60 mL/min, and 20.3 (9.95-41.3) for eGFR < 30 mL/min], and higher C reactive protein (CRP) (OR 1.81 (1.11-2.95) in patients with initial CRP > 10 mg/L). Compared to patients without COVID-19 and without AKI, the risk of in-hospital death was highest in patients with COVID-19 and AKI [OR 80.3, 95% CI (27.3-235.6)], followed by COVID-19 without AKI [16.3 (6.28-42.4)], and by patients without COVID-19 and with AKI [10.2 (3.66-28.2)].\n\nGeriatric patients hospitalized with COVID-19 had a higher incidence of AKI compared to patients hospitalized for other diagnoses. COVID-19 and reduced baseline kidney function were risk factors for developing AKI. AKI and COVID-19 were associated with in-hospital death.", "doi": "10.1007/s40620-021-01022-0", "pmid": "33751497", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40620-021-01022-0"}], "notes": [], "created": "2021-03-24T06:55:25.358Z", "modified": "2021-03-24T06:56:15.523Z"}, {"entity": "publication", "iuid": "c737c114c2434b338293ab491edc103d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c737c114c2434b338293ab491edc103d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c737c114c2434b338293ab491edc103d"}}, "title": "Identification of Potential SARS-CoV-2 Main Protease and Spike Protein Inhibitors from the Genus Aloe: An In Silico Study for Drug Development.", "authors": [{"family": "Abouelela", "given": "Mohamed E", "initials": "ME"}, {"family": "Assaf", "given": "Hamdy K", "initials": "HK"}, {"family": "Abdelhamid", "given": "Reda A", "initials": "RA"}, {"family": "Elkhyat", "given": "Ehab S", "initials": "ES"}, {"family": "Sayed", "given": "Ahmed M", "initials": "AM"}, {"family": "Oszako", "given": "Tomasz", "initials": "T"}, {"family": "Belbahri", "given": "Lassaad", "initials": "L"}, {"family": "El Zowalaty", "given": "Ahmed E", "initials": "AE"}, {"family": "Abdelkader", "given": "Mohamed Salaheldin A", "initials": "MSA"}], "type": "journal article", "published": "2021-03-21", "journal": {"title": "Molecules", "issn": "1420-3049", "volume": "26", "issue": "6", "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus (SARS-CoV-2) disease is a global rapidly spreading virus showing very high rates of complications and mortality. Till now, there is no effective specific treatment for the disease. Aloe is a rich source of isolated phytoconstituents that have an enormous range of biological activities. Since there are no available experimental techniques to examine these compounds for antiviral activity against SARS-CoV-2, we employed an in silico approach involving molecular docking, dynamics simulation, and binding free energy calculation using SARS-CoV-2 essential proteins as main protease and spike protein to identify lead compounds from Aloe that may help in novel drug discovery. Results retrieved from docking and molecular dynamics simulation suggested a number of promising inhibitors from Aloe. Root mean square deviation (RMSD) and root mean square fluctuation (RMSF) calculations indicated that compounds 132, 134, and 159 were the best scoring compounds against main protease, while compounds 115, 120, and 131 were the best scoring ones against spike glycoprotein. Compounds 120 and 131 were able to achieve significant stability and binding free energies during molecular dynamics simulation. In addition, the highest scoring compounds were investigated for their pharmacokinetic properties and drug-likeness. The Aloe compounds are promising active phytoconstituents for drug development for SARS-CoV-2.", "doi": "10.3390/molecules26061767", "pmid": "33801151", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "molecules26061767"}], "notes": [], "created": "2021-04-06T10:39:45.088Z", "modified": "2021-04-06T10:39:45.099Z"}, {"entity": "publication", "iuid": "c23fb84e01e842a283193fca3cd80504", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c23fb84e01e842a283193fca3cd80504.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c23fb84e01e842a283193fca3cd80504"}}, "title": "Fear of COVID-19 Scale (FCV-19S) across countries: Measurement invariance issues.", "authors": [{"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Hou", "given": "Wen-Li", "initials": "W"}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA"}, {"family": "Aparecido da Silva", "given": "Jos\u00e9", "initials": "J"}, {"family": "Broche-P\u00e9rez", "given": "Yunier", "initials": "Y"}, {"family": "Ullah", "given": "Irfan", "initials": "I"}, {"family": "Masuyama", "given": "Akihiro", "initials": "A"}, {"family": "Wakashima", "given": "Koubun", "initials": "K"}, {"family": "Mailliez", "given": "M\u00e9lody", "initials": "M"}, {"family": "Carre", "given": "Arnaud", "initials": "A"}, {"family": "Chen", "given": "Yu-Pin", "initials": "Y"}, {"family": "Chang", "given": "Kun-Chia", "initials": "K"}, {"family": "Kuo", "given": "Yi-Jie", "initials": "Y"}, {"family": "Soraci", "given": "Paolo", "initials": "P"}, {"family": "Scarf", "given": "Damian", "initials": "D"}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-03-21", "journal": {"title": "Nurs Open", "issn": "2054-1058", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The threats of novel coronavirus disease 2019 (COVID-19) have caused fears worldwide. The Fear of COVID-19 Scale (FCV-19S) was recently developed to assess the fear of COVID-19. Although many studies found that the FCV-19S is psychometrically sound, it is unclear whether the FCV-19S is invariant across countries. The present study aimed to examine the measurement invariance of the FCV-19S across eleven countries.\r\n\r\nCross-sectional study.\r\n\r\nUsing data collected from prior research on Bangladesh (N = 8,550), United Kingdom (N = 344), Brazil (N = 1,843), Taiwan (N = 539), Italy (N = 249), New Zealand (N = 317), Iran (N = 717), Cuba (N = 772), Pakistan (N = 937), Japan (N = 1,079) and France (N = 316), comprising a total 15,663 participants, the present study used the multigroup confirmatory factor analysis (CFA) and Rasch differential item functioning (DIF) to examine the measurement invariance of the FCV-19S across country, gender and age (children aged below 18 years, young to middle-aged adults aged between 18 and 60 years, and older people aged above 60 years).\r\n\r\nThe unidimensional structure of the FCV-19S was confirmed. Multigroup CFA showed that FCV-19S was partially invariant across country and fully invariant across gender and age. DIF findings were consistent with the findings from multigroup CFA. Many DIF items were displayed for country, few DIF items were displayed for age, and no DIF items were displayed for gender.\r\n\r\nBased on the results of the present study, the FCV-19S is a good psychometric instrument to assess fear of COVID-19 during the pandemic period. Moreover, the use of FCV-19S is supported in at least ten countries with satisfactory psychometric properties.", "doi": "10.1002/nop2.855", "pmid": "33745219", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-24T07:00:44.363Z", "modified": "2021-06-18T15:29:27.945Z"}, {"entity": "publication", "iuid": "a2a1735641c64bba9ec00b061e463c38", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2a1735641c64bba9ec00b061e463c38.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2a1735641c64bba9ec00b061e463c38"}}, "title": "Anti-SARS-CoV2 antibody responses in serum and cerebrospinal fluid of COVID-19 patients with neurological symptoms", "authors": [{"family": "Cunningham", "given": "Janet L", "initials": "JL"}, {"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B"}, {"family": "Castro Dopico", "given": "Xaquin", "initials": "X"}, {"family": "Kolstad", "given": "Linda", "initials": "L"}, {"family": "Albinsson", "given": "Bo", "initials": "B"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "N\u00e4\u00e4s", "given": "Anja", "initials": "A"}, {"family": "Klang", "given": "Andrea", "initials": "A"}, {"family": "Westman", "given": "Gabriel", "initials": "G"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e314740b02c344d2b336a9410e28041e.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Rostami", "given": "Elham", "initials": "E", "orcid": "0000-0003-1218-6247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c95efe7a4cc4fcfa73fac8b49641ca1.json"}}], "type": "journal-article", "published": "2021-03-21", "journal": {"title": "The Journal of Infectious Diseases", "issn": "0022-1899", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Antibody responses to SARS-CoV-2 in serum and CSF from 16 COVID-19 patients with neurological symptoms were assessed using two independent methods. IgG specific for the virus spike protein was found in 81% of cases in serum and in 56% in CSF. SARS-CoV-2 IgG in CSF was observed in two cases with negative serology. Levels of IgG in both serum and CSF were associated with disease severity (p<0.05). All patients with elevated markers of CNS damage in CSF also had CSF antibodies (p=0.002), and CSF antibodies had the highest predictive value for neuronal damage markers of all tested clinical variables.", "doi": "10.1093/infdis/jiab153", "pmid": "33744954", "labels": {"Category: Health": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Funder: VR": null, "Category: Proteins": null, "Funder: H2020": null, "Research Area: High-throughput and high-content serology": null}, "xrefs": [{"db": "pii", "key": "6179304"}, {"db": "pmc", "key": "PMC8083780"}], "notes": [], "created": "2021-03-22T10:01:02.020Z", "modified": "2021-12-12T18:07:55.909Z"}, {"entity": "publication", "iuid": "038bbdb7ac4b4dd283edbe6d0049a203", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/038bbdb7ac4b4dd283edbe6d0049a203.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/038bbdb7ac4b4dd283edbe6d0049a203"}}, "title": "An Agent-Based Model of Local Pandemic Spread: Analysis of SARS-CoV-2.", "authors": [{"family": "Staffini", "given": "Alessio", "initials": "A"}, {"family": "Svensson", "given": "Akiko Kishi", "initials": "AK"}, {"family": "Chung", "given": "Ung-Il", "initials": "UI"}, {"family": "Svensson", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2021-03-21", "journal": {"title": "JMIR Med Inform", "issn": "2291-9694", "volume": null, "issue": null, "issn-l": null}, "abstract": "The spread of the SARS-CoV-2 virus originating in Wuhan, China, was classified as a pandemic by the World Health Organization (WHO) on March 11, 2020. The governments of affected countries have implemented various measures to limit the spread of the virus. The starting point of this paper is the different government approaches, in terms of promulgating new legislative regulations to limit the virus diffusion and to contain negative effects on the populations.\n\nThe objective of this paper is to study how the spread of the SARS-CoV-2 virus is linked to the government policies, and to analyse how different policies have produced different results on public health.\n\nConsidering the official data provided by 4 countries (Italy, Germany, Sweden and Brazil) and from the measures implemented by their respective governments, we built an Agent-Based Model (ABM) to study the effects that these measures will have over time on different variables such as the total number of COVID-19 cases, intensive care unit (ICU) bed occupancy rates, and recovery and case fatality rates. The model we implemented provides for the possibility of modifying some starting variables, and it was thus possible to study the effects that some policies (such as keeping the national borders closed or the increase in ICU beds) would have had on the spread of the infection.\n\nThe 4 considered countries have adopted different containment measures for SARS-CoV-2, and the forecasts provided by the model for the considered variables have given different results. Italy and Germany seem to be able to limit the spread of the infection and any eventual \"second wave\", while Sweden and Brazil do not seem to have the situation under control. This situation is reflected also in the forecasts of pressure on the National Health Services, which see Sweden and Brazil with a high occupancy rate of ICU beds also in the coming months, with a consequent high number of deaths.\n\nIn line with what we expected, the obtained results show that the countries that have taken very restrictive measures in terms of limiting the mobility of the population have managed, more successfully than others, to contain the spread of SARS-CoV-2. Moreover, the model demonstrates that herd immunity cannot be reached even in countries which have relied on a strategy without strict containment measures.\n\nNot Applicable.", "doi": "10.2196/24192", "pmid": "33750735", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-03-24T06:57:45.986Z", "modified": "2021-03-24T06:57:57.046Z"}, {"entity": "publication", "iuid": "2ccb5a5c59b647dbb970f0e5430d547c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ccb5a5c59b647dbb970f0e5430d547c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ccb5a5c59b647dbb970f0e5430d547c"}}, "title": "A bispecific monomeric nanobody induces SARS-COV-2 spike trimer dimers", "authors": [{"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Das", "given": "Hrishikesh", "initials": "H"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Vidakovics", "given": "Laura Perez", "initials": "LP"}, {"family": "Urgard", "given": "Egon", "initials": "E"}, {"family": "Moliner-Morro", "given": "Ainhoa", "initials": "A"}, {"family": "Karl", "given": "Vivien", "initials": "V"}, {"family": "Pankow", "given": "Alec", "initials": "A"}, {"family": "Kim", "given": "Changil", "initials": "C"}, {"family": "Smith", "given": "Natalie L", "initials": "NL"}, {"family": "Pedersen", "given": "Gabriel K", "initials": "GK"}, {"family": "Coquet", "given": "Jonathan M", "initials": "JM"}, {"family": "H\u00e4llberg", "given": "B Martin", "initials": "BM"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}], "type": "posted-content", "published": "2021-03-21", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.20.436243", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "Materials will be made available when the article is published in a journal", "description": null}], "notes": [], "created": "2021-03-24T06:32:39.788Z", "modified": "2021-04-15T18:54:39.609Z"}, {"entity": "publication", "iuid": "2e9b4e77e3da40ebbfa0ec005dcac230", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e9b4e77e3da40ebbfa0ec005dcac230.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e9b4e77e3da40ebbfa0ec005dcac230"}}, "title": "COVID-19 collateral damage: psychological distress and behavioral changes among older adults during the first outbreak in Stockholm, Sweden", "authors": [{"family": "Beridze", "given": "Giorgi", "initials": "G"}, {"family": "Triolo", "given": "Federico", "initials": "F"}, {"family": "Grande", "given": "Giulia", "initials": "G"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A"}], "type": "posted-content", "published": "2021-03-20", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.16.21253750", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null, "Funder: VR": null}, "xrefs": [{"db": "URL", "key": "http://www.snac-k.se/", "description": "Data available through the the Swedish National study on Aging and Care in Kungsholmen"}], "notes": [], "created": "2021-03-25T14:03:00.839Z", "modified": "2021-04-26T18:07:59.411Z"}, {"entity": "publication", "iuid": "cc0d3b576b9545758a36e109cd7cb47d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc0d3b576b9545758a36e109cd7cb47d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc0d3b576b9545758a36e109cd7cb47d"}}, "title": "Alternative splicing of OAS1 alters the risk for severe COVID-19", "authors": [{"family": "Huffman", "given": "Jennifer", "initials": "J"}, {"family": "Butler-Laporte", "given": "Guillaume", "initials": "G"}, {"family": "Khan", "given": "Atlas", "initials": "A"}, {"family": "Drivas", "given": "Theodore G", "initials": "TG"}, {"family": "Peloso", "given": "Gina M", "initials": "GM"}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T"}, {"family": "Verma", "given": "Anurag", "initials": "A"}, {"family": "Kiryluk", "given": "Krzysztof", "initials": "K"}, {"family": "Richards", "given": "J Brent", "initials": "JB"}, {"family": "Zeberg", "given": "Hugo", "initials": "H"}], "type": "posted-content", "published": "2021-03-20", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.20.21254005", "pmid": null, "labels": {"Category: Genomics & transcriptomics": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-03-25T14:09:33.955Z", "modified": "2021-03-29T10:15:48.708Z"}, {"entity": "publication", "iuid": "e053d3a1434949cba8dbc6919d1f7f5a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e053d3a1434949cba8dbc6919d1f7f5a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e053d3a1434949cba8dbc6919d1f7f5a"}}, "title": "Umbilical cord blood-derived microglia-like cells to model COVID-19 exposure.", "authors": [{"family": "Sheridan", "given": "Steven D", "initials": "SD"}, {"family": "Thanos", "given": "Jessica M", "initials": "JM", "orcid": "0000-0001-7984-5361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc172e4bc4f14c81b166a2d59a696dc8.json"}}, {"family": "De Guzman", "given": "Rose M", "initials": "RM", "orcid": "0000-0002-4563-8628", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/288794dac78b4cb4b0d22b66d11d96d0.json"}}, {"family": "McCrea", "given": "Liam T", "initials": "LT", "orcid": "0000-0002-6738-4681", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3433cc21b02f4c3da64a9b0d78b7af64.json"}}, {"family": "Horng", "given": "Joy E", "initials": "JE"}, {"family": "Fu", "given": "Ting", "initials": "T"}, {"family": "Sellgren", "given": "Carl M", "initials": "CM"}, {"family": "Perlis", "given": "Roy H", "initials": "RH", "orcid": "0000-0002-5862-6757", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1335ae4cb1c48b3987d8e3188ca7a33.json"}}, {"family": "Edlow", "given": "Andrea G", "initials": "AG"}], "type": "journal article", "published": "2021-03-19", "journal": {"title": "Transl Psychiatry", "issn": "2158-3188", "volume": "11", "issue": "1", "pages": "179", "issn-l": null}, "abstract": "Microglia, the resident brain immune cells, play a critical role in normal brain development, and are impacted by the intrauterine environment, including maternal immune activation and inflammatory exposures. The COVID-19 pandemic presents a potential developmental immune challenge to the fetal brain, in the setting of maternal SARS-CoV-2 infection with its attendant potential for cytokine production and, in severe cases, cytokine storming. There is currently no biomarker or model for in utero microglial priming and function that might aid in identifying the neonates and children most vulnerable to neurodevelopmental morbidity, as microglia remain inaccessible in fetal life and after birth. This study aimed to generate patient-derived microglial-like cell models unique to each neonate from reprogrammed umbilical cord blood mononuclear cells, adapting and extending a novel methodology previously validated for adult peripheral blood mononuclear cells. We demonstrate that umbilical cord blood mononuclear cells can be used to create microglial-like cell models morphologically and functionally similar to microglia observed in vivo. We illustrate the application of this approach by generating microglia from cells exposed and unexposed to maternal SARS-CoV-2 infection. Our ability to create personalized neonatal models of fetal brain immune programming enables non-invasive insights into fetal brain development and potential childhood neurodevelopmental vulnerabilities for a range of maternal exposures, including COVID-19.", "doi": "10.1038/s41398-021-01287-w", "pmid": "33741894", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41398-021-01287-w"}, {"db": "pmc", "key": "PMC7976669"}], "notes": [], "created": "2021-03-22T10:28:54.662Z", "modified": "2021-11-18T13:50:03.787Z"}, {"entity": "publication", "iuid": "443177b2f06947178dc99c1684f325fb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/443177b2f06947178dc99c1684f325fb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/443177b2f06947178dc99c1684f325fb"}}, "title": "Exploring associations between children's obesogenic behaviours and local environment using big data.", "authors": [{"family": "Filos", "given": "Dimitris", "initials": "D"}, {"family": "Lekka", "given": "Irini", "initials": "I"}, {"family": "Kilintzis", "given": "Vasileios", "initials": "V"}, {"family": "Stefanopoulos", "given": "Leandros", "initials": "L"}, {"family": "Karavidopoulou", "given": "Youla", "initials": "Y"}, {"family": "Maramis", "given": "Christos", "initials": "C"}, {"family": "Diou", "given": "Christos", "initials": "C"}, {"family": "Sarafis", "given": "Ioannis", "initials": "I"}, {"family": "Papapanagiotou", "given": "Vasileios", "initials": "V"}, {"family": "Alagialoglou", "given": "Leonidas", "initials": "L"}, {"family": "Ioakeimidis", "given": "Ioannis", "initials": "I"}, {"family": "Hassapidou", "given": "Maria", "initials": "M"}, {"family": "Charmandari", "given": "Evangelia", "initials": "E"}, {"family": "Heimeier", "given": "Rachel", "initials": "R"}, {"family": "O'Donnell", "given": "Shane", "initials": "S"}, {"family": "Doyle", "given": "Gerardine", "initials": "G"}, {"family": "Delopoulos", "given": "Anastasios", "initials": "A"}, {"family": "Maglaveras", "given": "Nicos", "initials": "N"}], "type": "journal article", "published": "2021-03-19", "journal": {"title": "JMIR Mhealth Uhealth", "issn": "2291-5222", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Obesity is a major public health problem globally and in Europe, while the prevalence of childhood obesity is also soaring. Several parameters of the living environment are contributing to this increase, such as the density of fast-food retailers, and thus, preventive health policies against childhood obesity must focus on the environment to which children are exposed. Currently, there are no systems to objectively measure the effect of living environment parameters on obesogenic behaviours and obesity. The H2020 project \"BigO: Big Data Against Childhood Obesity\" (http://bigoprogram.eu) aims to tackle childhood obesity by creating new sources of evidence based on big data.\r\n\r\nThis paper introduces the Obesity Prevention dashboard (OPdashboard), implemented in the context of BigO, which offers an interactive data exploration of objective obesity related behaviours and local environment based on the data recorded using the BigO mHealth app.\r\n\r\nOPdashboard allows for (i) the real time monitoring of children's obesogenic behaviours in a city area, (ii) the extraction of associations between them and the local environment and, (iii) the evaluation of an intervention in time. More than 3700 children, from 33 schools and 2 clinics, in 5 European cities have been monitored using a custom-made mobile application for the extraction of behavioural patterns through the capturing of accelerometer and geolocation data, while online databases were assessed in order to have a description of the environment.\r\n\r\nThe preliminary association outcomes in two European cities, namely Thessaloniki in Greece and Stockholm in Sweden, indicate a correlation between children's eating and physical activity behaviours and the availability of food related places or sport facilities close to schools. In addition, OPdashboard was used to assess the modification of children's physical activity as the result of the health policies applied for the deceleration of the COVID-19 outbreak. The preliminary outcomes of the analysis revealed that in urban areas the decrease on physical activity was statistically significant, while in the suburbs a slight increase was observed. Those findings suggest the importance of the availability of open spaces on children's behavioural change. The above analyses act as initial investigations using the OPdashboard. Additional factors must be incorporated in order to optimize its use and have a clearer understanding of the results.\r\n\r\nThe paper describes in detail the OPdashboard which is exposed as a web interface (http://bigo.med.auth.gr:3838/). Its functionality was evaluated during a focus group with experts on public health, where its potential on the better understanding of the interplay between children's obesogenic behaviours and the environment was underlined.", "doi": "10.2196/26290", "pmid": "34048353", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-06-04T11:40:32.420Z", "modified": "2022-11-23T09:01:40.333Z"}, {"entity": "publication", "iuid": "9ddc9e800b23454e99345e581344e71c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ddc9e800b23454e99345e581344e71c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ddc9e800b23454e99345e581344e71c"}}, "title": "A privacy and security analysis of early-deployed COVID-19 contact tracing Android apps.", "authors": [{"family": "Hatamian", "given": "Majid", "initials": "M"}, {"family": "Wairimu", "given": "Samuel", "initials": "S"}, {"family": "Momen", "given": "Nurul", "initials": "N"}, {"family": "Fritsch", "given": "Lothar", "initials": "L"}], "type": "journal article", "published": "2021-03-19", "journal": {"title": "Empir Softw Eng", "issn": "1573-7616", "volume": "26", "issue": "3", "pages": "36", "issn-l": null}, "abstract": "As this article is being drafted, the SARS-CoV-2/COVID-19 pandemic is causing harm and disruption across the world. Many countries aimed at supporting their contact tracers with the use of digital contact tracing apps in order to manage and control the spread of the virus. Their idea is the automatic registration of meetings between smartphone owners for the quicker processing of infection chains. To date, there are many contact tracing apps that have already been launched and used in 2020. There has been a lot of speculations about the privacy and security aspects of these apps and their potential violation of data protection principles. Therefore, the developers of these apps are constantly criticized because of undermining users' privacy, neglecting essential privacy and security requirements, and developing apps under time pressure without considering privacy- and security-by-design. In this study, we analyze the privacy and security performance of 28 contact tracing apps available on Android platform from various perspectives, including their code's privileges, promises made in their privacy policies, and static and dynamic performances. Our methodology is based on the collection of various types of data concerning these 28 apps, namely permission requests, privacy policy texts, run-time resource accesses, and existing security vulnerabilities. Based on the analysis of these data, we quantify and assess the impact of these apps on users' privacy. We aimed at providing a quick and systematic inspection of the earliest contact tracing apps that have been deployed on multiple continents. Our findings have revealed that the developers of these apps need to take more cautionary steps to ensure code quality and to address security and privacy vulnerabilities. They should more consciously follow legal requirements with respect to apps' permission declarations, privacy principles, and privacy policy contents.", "doi": "10.1007/s10664-020-09934-4", "pmid": "33776548", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "9934"}, {"db": "pmc", "key": "PMC7978168"}], "notes": [], "created": "2021-03-30T12:15:34.168Z", "modified": "2021-03-30T12:15:34.179Z"}, {"entity": "publication", "iuid": "a9f78ac5ac6a4f04858a5282781170b8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a9f78ac5ac6a4f04858a5282781170b8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a9f78ac5ac6a4f04858a5282781170b8"}}, "title": "Proteomic blood profiling in mild, severe and critical COVID-19 patients.", "authors": [{"family": "Patel", "given": "Hamel", "initials": "H", "orcid": "0000-0001-7951-6728", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21f5082b1f284a9b901e66759825d8c6.json"}}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0002-3579-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0ae25211e354556a737b1a23c53c6e1.json"}}, {"family": "Dobson", "given": "Richard J B", "initials": "RJB", "orcid": "0000-0003-4224-9245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e3de8d16fca4e7f86f4b1245047e9d0.json"}}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Gisslen", "given": "Magnus", "initials": "M"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e314740b02c344d2b336a9410e28041e.json"}}], "type": "comparative study", "published": "2021-03-18", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "6357"}, "abstract": "The recent SARS-CoV-2 pandemic manifests itself as a mild respiratory tract infection in most individuals, leading to COVID-19 disease. However, in some infected individuals, this can progress to severe pneumonia and acute respiratory distress syndrome (ARDS), leading to multi-organ failure and death. This study explores the proteomic differences between mild, severe, and critical COVID-19 positive patients to further understand the disease progression, identify proteins associated with disease severity, and identify potential therapeutic targets. Blood protein profiling was performed on 59 COVID-19 mild (n = 26), severe (n = 9) or critical (n = 24) cases and 28 controls using the OLINK inflammation, autoimmune, cardiovascular and neurology panels. Differential expression analysis was performed within and between disease groups to generate nine different analyses. From the 368 proteins measured per individual, more than 75% were observed to be significantly perturbed in COVID-19 cases. Six proteins (IL6, CKAP4, Gal-9, IL-1ra, LILRB4 and PD-L1) were identified to be associated with disease severity. The results have been made readily available through an interactive web-based application for instant data exploration and visualization, and can be accessed at https://phidatalab-shiny.rosalind.kcl.ac.uk/COVID19/ . Our results demonstrate that dynamic changes in blood proteins associated with disease severity can potentially be used as early biomarkers to monitor disease severity in COVID-19 and serve as potential therapeutic targets.", "doi": "10.1038/s41598-021-85877-0", "pmid": "33737684", "labels": {"Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Biomarkers and systems immunology": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7973581"}, {"db": "pii", "key": "10.1038/s41598-021-85877-0"}], "notes": [], "created": "2020-11-11T06:47:50.601Z", "modified": "2023-06-19T14:41:38.563Z"}, {"entity": "publication", "iuid": "10d64921899648ee8b9c8e5d2b75d28f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/10d64921899648ee8b9c8e5d2b75d28f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/10d64921899648ee8b9c8e5d2b75d28f"}}, "title": "Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care.", "authors": [{"family": "Pillon", "given": "Nicolas J", "initials": "NJ"}, {"family": "Loos", "given": "Ruth J F", "initials": "RJF"}, {"family": "Marshall", "given": "Sally M", "initials": "SM"}, {"family": "Zierath", "given": "Juleen R", "initials": "JR"}], "type": "journal article", "published": "2021-03-18", "journal": {"title": "Cell", "issn": "1097-4172", "issn-l": "0092-8674", "volume": "184", "issue": "6", "pages": "1530-1544"}, "abstract": "The prevalence of type 2 diabetes and obesity has risen dramatically for decades and is expected to rise further, secondary to the growing aging, sedentary population. The strain on global health care is projected to be colossal. This review explores the latest work and emerging ideas related to genetic and environmental factors influencing metabolism. Translational research and clinical applications, including the impact of the COVID-19 pandemic, are highlighted. Looking forward, strategies to personalize all aspects of prevention, management and care are necessary to improve health outcomes and reduce the impact of these metabolic diseases.", "doi": "10.1016/j.cell.2021.02.012", "pmid": "33675692", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0092-8674(21)00162-8"}], "notes": [], "created": "2021-03-08T10:47:30.864Z", "modified": "2021-11-18T11:57:32.775Z"}, {"entity": "publication", "iuid": "49040feeb8204cadb4e9d7acb2c4f66a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49040feeb8204cadb4e9d7acb2c4f66a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49040feeb8204cadb4e9d7acb2c4f66a"}}, "title": "Working from home during the COVID-19 outbreak in Sweden: effects on 24-h time-use in office workers.", "authors": [{"family": "Hallman", "given": "David M", "initials": "DM"}, {"family": "Januario", "given": "Leticia Bergamin", "initials": "LB"}, {"family": "Mathiassen", "given": "Svend Erik", "initials": "SE"}, {"family": "Heiden", "given": "Marina", "initials": "M"}, {"family": "Svensson", "given": "Sven", "initials": "S"}, {"family": "Bergstr\u00f6m", "given": "Gunnar", "initials": "G"}], "type": "journal article", "published": "2021-03-17", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "528"}, "abstract": "The COVID-19 pandemic has triggered national recommendations encouraging people to work from home (WFH), but the possible impact of WFH on physical behaviors is unknown. This study aimed to determine the extent to which the 24-h allocation of time to different physical behaviors changes between days working at the office (WAO) and days WFH in office workers during the pandemic.\r\n\r\nData were collected on 27 office workers with full-time employment at a Swedish municipal division during the COVID-19 outbreak in May-July 2020. A thigh-worn accelerometer (Axivity) was used to assess physical behavior (sedentary, stand, move) during seven consecutive days. A diary was used to identify periods of work, leisure and sleep. 24-h compositions of sedentary, standing and moving behaviors during work and non-work time were examined using Compositional data analysis (CoDA), and differences between days WAO and days WFH were determined using repeated measures ANOVA.\r\n\r\nDays WFH were associated with more time spent sleeping relative to awake, and the effect size was large (F = 7.4; p = 0.01; \u03b7 p2 = 0.22). The increase (34 min) in sleep time during WFH occurred at the expense of a reduction in work and leisure time by 26 min and 7 min, respectively. Sedentary, standing and moving behaviors did not change markedly during days WFH compared to days WAO.\r\n\r\nDays working from home during the COVID-19 pandemic in Sweden were associated with longer duration of sleep than days working at the office. This behavioral change may be beneficial to health.", "doi": "10.1186/s12889-021-10582-6", "pmid": "33731066", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-10582-6"}, {"db": "pmc", "key": "PMC7968563"}], "notes": [], "created": "2021-03-22T10:50:49.831Z", "modified": "2021-06-18T15:27:29.077Z"}, {"entity": "publication", "iuid": "1716a22867ba40bc9096731dff09d97c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1716a22867ba40bc9096731dff09d97c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1716a22867ba40bc9096731dff09d97c"}}, "title": "Assessment of protection against reinfection with SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020: a population-level observational study.", "authors": [{"family": "Hansen", "given": "Christian Holm", "initials": "CH"}, {"family": "Michlmayr", "given": "Daniela", "initials": "D"}, {"family": "Gubbels", "given": "Sophie Madeleine", "initials": "SM"}, {"family": "M\u00f8lbak", "given": "K\u00e5re", "initials": "K"}, {"family": "Ethelberg", "given": "Steen", "initials": "S"}], "type": "journal article", "published": "2021-03-17", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": null, "issue": null, "issn-l": "0140-6736"}, "abstract": "The degree to which infection with SARS-CoV-2 confers protection towards subsequent reinfection is not well described. In 2020, as part of Denmark's extensive, free-of-charge PCR-testing strategy, approximately 4 million individuals (69% of the population) underwent 10\u00b76 million tests. Using these national PCR-test data from 2020, we estimated protection towards repeat infection with SARS-CoV-2.\n\nIn this population-level observational study, we collected individual-level data on patients who had been tested in Denmark in 2020 from the Danish Microbiology Database and analysed infection rates during the second surge of the COVID-19 epidemic, from Sept 1 to Dec 31, 2020, by comparison of infection rates between individuals with positive and negative PCR tests during the first surge (March to May, 2020). For the main analysis, we excluded people who tested positive for the first time between the two surges and those who died before the second surge. We did an alternative cohort analysis, in which we compared infection rates throughout the year between those with and without a previous confirmed infection at least 3 months earlier, irrespective of date. We also investigated whether differences were found by age group, sex, and time since infection in the alternative cohort analysis. We calculated rate ratios (RRs) adjusted for potential confounders and estimated protection against repeat infection as 1 - RR.\n\nDuring the first surge (ie, before June, 2020), 533 381 people were tested, of whom 11 727 (2\u00b720%) were PCR positive, and 525 339 were eligible for follow-up in the second surge, of whom 11 068 (2\u00b711%) had tested positive during the first surge. Among eligible PCR-positive individuals from the first surge of the epidemic, 72 (0\u00b765% [95% CI 0\u00b751-0\u00b782]) tested positive again during the second surge compared with 16 819 (3\u00b727% [3\u00b722-3\u00b732]) of 514 271 who tested negative during the first surge (adjusted RR 0\u00b7195 [95% CI 0\u00b7155-0\u00b7246]). Protection against repeat infection was 80\u00b75% (95% CI 75\u00b74-84\u00b75). The alternative cohort analysis gave similar estimates (adjusted RR 0\u00b7212 [0\u00b7179-0\u00b7251], estimated protection 78\u00b78% [74\u00b79-82\u00b71]). In the alternative cohort analysis, among those aged 65 years and older, observed protection against repeat infection was 47\u00b71% (95% CI 24\u00b77-62\u00b78). We found no difference in estimated protection against repeat infection by sex (male 78\u00b74% [72\u00b71-83\u00b72] vs female 79\u00b71% [73\u00b79-83\u00b73]) or evidence of waning protection over time (3-6 months of follow-up 79\u00b73% [74\u00b74-83\u00b73] vs \u22657 months of follow-up 77\u00b77% [70\u00b79-82\u00b79]).\n\nOur findings could inform decisions on which groups should be vaccinated and advocate for vaccination of previously infected individuals because natural protection, especially among older people, cannot be relied on.\n\nNone.", "doi": "10.1016/S0140-6736(21)00575-4", "pmid": "33743221", "labels": {"Category: Public Health": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)00575-4"}], "notes": [], "created": "2021-03-22T10:13:10.682Z", "modified": "2021-03-22T10:13:10.692Z"}, {"entity": "publication", "iuid": "7f2312c9703141e0992299306a9f8e5e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f2312c9703141e0992299306a9f8e5e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f2312c9703141e0992299306a9f8e5e"}}, "title": "Virological and immunological features of SARS-CoV-2-infected children who develop neutralizing antibodies.", "authors": [{"family": "Cotugno", "given": "Nicola", "initials": "N"}, {"family": "Ruggiero", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-1041-7489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e47b6216d0514a37818f676dce75ff57.json"}}, {"family": "Bonfante", "given": "Francesco", "initials": "F"}, {"family": "Petrara", "given": "Maria Raffaella", "initials": "MR"}, {"family": "Zicari", "given": "Sonia", "initials": "S", "orcid": "0000-0003-1240-8057", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0379fd354fd3492aa5d5fe8ea9e16065.json"}}, {"family": "Pascucci", "given": "Giuseppe Rubens", "initials": "GR", "orcid": "0000-0002-5978-1193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cfa33536b1242949e2195412e11f541.json"}}, {"family": "Zangari", "given": "Paola", "initials": "P"}, {"family": "De Ioris", "given": "Maria Antonietta", "initials": "MA"}, {"family": "Santilli", "given": "Veronica", "initials": "V"}, {"family": "Manno", "given": "E C", "initials": "EC"}, {"family": "Amodio", "given": "Donato", "initials": "D", "orcid": "0000-0003-4550-3018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8036babccffd453ab3dda55c13a204fa.json"}}, {"family": "Bortolami", "given": "Alessio", "initials": "A"}, {"family": "Pagliari", "given": "Matteo", "initials": "M"}, {"family": "Concato", "given": "Carlo", "initials": "C"}, {"family": "Linardos", "given": "Giulia", "initials": "G"}, {"family": "Campana", "given": "Andrea", "initials": "A"}, {"family": "Don\u00e0", "given": "Daniele", "initials": "D"}, {"family": "Giaquinto", "given": "Carlo", "initials": "C"}, {"family": "CACTUS Study Team", "given": "", "initials": ""}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}, {"family": "Rossi", "given": "Paolo", "initials": "P"}, {"family": "De Rossi", "given": "Anita", "initials": "A", "orcid": "0000-0001-6435-7509", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a4a32409ace4604983c5773c28c7c9e.json"}}, {"family": "Palma", "given": "Paolo", "initials": "P", "orcid": "0000-0002-3066-4719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36e1a02e86a142c2b2d131154fb46f1c.json"}}], "type": "journal article", "published": "2021-03-16", "journal": {"title": "Cell Rep", "issn": "2211-1247", "volume": "34", "issue": "11", "pages": "108852", "issn-l": null}, "abstract": "As the global COVID-19 pandemic progresses, it is paramount to gain knowledge on adaptive immunity to SARS-CoV-2 in children to define immune correlates of protection upon immunization or infection. We analyzed anti-SARS-CoV-2 antibodies and their neutralizing activity (PRNT) in 66 COVID-19-infected children at 7 (\u00b12) days after symptom onset. Individuals with specific humoral responses presented faster virus clearance and lower viral load associated with a reduced in vitro infectivity. We demonstrated that the frequencies of SARS-CoV-2-specific CD4+CD40L+ T cells and Spike-specific B cells were associated with the anti-SARS-CoV-2 antibodies and the magnitude of neutralizing activity. The plasma proteome confirmed the association between cellular and humoral SARS-CoV-2 immunity, and PRNT+ patients show higher viral signal transduction molecules (SLAMF1, CD244, CLEC4G). This work sheds lights on cellular and humoral anti-SARS-CoV-2 responses in children, which may drive future vaccination trial endpoints and quarantine measures policies.", "doi": "10.1016/j.celrep.2021.108852", "pmid": "33730580", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7962998"}, {"db": "pii", "key": "S2211-1247(21)00166-2"}], "notes": [], "created": "2021-03-22T10:53:29.904Z", "modified": "2023-06-19T15:18:16.124Z"}, {"entity": "publication", "iuid": "bcf96a7cfc6548a3b5054f75641dca84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bcf96a7cfc6548a3b5054f75641dca84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bcf96a7cfc6548a3b5054f75641dca84"}}, "title": "Impact of COVID-19 pandemic on utilisation of healthcare services: a systematic review.", "authors": [{"family": "Moynihan", "given": "Ray", "initials": "R"}, {"family": "Sanders", "given": "Sharon", "initials": "S"}, {"family": "Michaleff", "given": "Zoe A", "initials": "ZA"}, {"family": "Scott", "given": "Anna Mae", "initials": "AM"}, {"family": "Clark", "given": "Justin", "initials": "J"}, {"family": "To", "given": "Emma J", "initials": "EJ"}, {"family": "Jones", "given": "Mark", "initials": "M"}, {"family": "Kitchener", "given": "Eliza", "initials": "E"}, {"family": "Fox", "given": "Melissa", "initials": "M"}, {"family": "Johansson", "given": "Minna", "initials": "M"}, {"family": "Lang", "given": "Eddy", "initials": "E"}, {"family": "Duggan", "given": "Anne", "initials": "A"}, {"family": "Scott", "given": "Ian", "initials": "I"}, {"family": "Albarqouni", "given": "Loai", "initials": "L"}], "type": "journal article", "published": "2021-03-16", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "3", "pages": "e045343", "issn-l": "2044-6055"}, "abstract": "To determine the extent and nature of changes in utilisation of healthcare services during COVID-19 pandemic.\n\nSystematic review.\n\nEligible studies compared utilisation of services during COVID-19 pandemic to at least one comparable period in prior years. Services included visits, admissions, diagnostics and therapeutics. Studies were excluded if from single centres or studied only patients with COVID-19.\n\nPubMed, Embase, Cochrane COVID-19 Study Register and preprints were searched, without language restrictions, until 10 August, using detailed searches with key concepts including COVID-19, health services and impact.\n\nRisk of bias was assessed by adapting the Risk of Bias in Non-randomised Studies of Interventions tool, and a Cochrane Effective Practice and Organization of Care tool. Results were analysed using descriptive statistics, graphical figures and narrative synthesis.\n\nPrimary outcome was change in service utilisation between prepandemic and pandemic periods. Secondary outcome was the change in proportions of users of healthcare services with milder or more severe illness (eg, triage scores).\n\n3097 unique references were identified, and 81 studies across 20 countries included, reporting on >11 million services prepandemic and 6.9 million during pandemic. For the primary outcome, there were 143 estimates of changes, with a median 37% reduction in services overall (IQR -51% to -20%), comprising median reductions for visits of 42% (-53% to -32%), admissions 28% (-40% to -17%), diagnostics 31% (-53% to -24%) and for therapeutics 30% (-57% to -19%). Among 35 studies reporting secondary outcomes, there were 60 estimates, with 27 (45%) reporting larger reductions in utilisation among people with a milder spectrum of illness, and 33 (55%) reporting no difference.\n\nHealthcare utilisation decreased by about a third during the pandemic, with considerable variation, and with greater reductions among people with less severe illness. While addressing unmet need remains a priority, studies of health impacts of reductions may help health systems reduce unnecessary care in the postpandemic recovery.\n\nCRD42020203729.", "doi": "10.1136/bmjopen-2020-045343", "pmid": "33727273", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-045343"}, {"db": "pmc", "key": "PMC7969768"}], "notes": [], "created": "2021-03-22T11:33:37.299Z", "modified": "2021-03-22T11:33:47.567Z"}, {"entity": "publication", "iuid": "b55606ceb58b4ef0a6080dc2afa9ee50", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b55606ceb58b4ef0a6080dc2afa9ee50.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b55606ceb58b4ef0a6080dc2afa9ee50"}}, "title": "COVIDENZA - A prospective, multicenter, randomized PHASE II clinical trial of enzalutamide treatment to decrease the morbidity in patients with Corona virus disease 2019 (COVID-19): a structured summary of a study protocol for a randomised controlled trial.", "authors": [{"family": "Wel\u00e9n", "given": "Karin", "initials": "K"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Freyhult", "given": "Eva", "initials": "E"}, {"family": "Robinsson", "given": "David", "initials": "D"}, {"family": "Henningsson", "given": "Anna Jonsson", "initials": "AJ"}, {"family": "Stranne", "given": "Johan", "initials": "J"}, {"family": "Bremell", "given": "Daniel", "initials": "D"}, {"family": "Angelin", "given": "Martin", "initials": "M"}, {"family": "Lindquist", "given": "Elisabeth", "initials": "E"}, {"family": "Buckland", "given": "Robert", "initials": "R"}, {"family": "Carlsson", "given": "Camilla Thellenberg", "initials": "CT"}, {"family": "Pauksens", "given": "Karlis", "initials": "K"}, {"family": "Bill-Axelsson", "given": "Anna", "initials": "A"}, {"family": "Akre", "given": "Olof", "initials": "O"}, {"family": "Ryden", "given": "Cecilia", "initials": "C"}, {"family": "Wagenius", "given": "Magnus", "initials": "M"}, {"family": "Bjartell", "given": "Anders", "initials": "A"}, {"family": "Nilsson", "given": "Anna C", "initials": "AC"}, {"family": "Styrke", "given": "Johan", "initials": "J"}, {"family": "Repo", "given": "Johanna", "initials": "J"}, {"family": "Balkhed", "given": "\u00c5se \u00d6stholm", "initials": "\u00c5\u00d6"}, {"family": "Niward", "given": "Katarina", "initials": "K"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Josefsson", "given": "Andreas", "initials": "A"}], "type": "letter", "published": "2021-03-16", "journal": {"title": "Trials", "issn": "1745-6215", "issn-l": null, "volume": "22", "issue": "1", "pages": "209"}, "abstract": "The main goal of the COVIDENZA trial is to evaluate if inhibition of testosterone signalling by enzalutamide can improve the outcome of patients hospitalised for COVID-19. The hypothesis is based on the observation that the majority of patients in need of intensive care are male, and the connection between androgen receptor signalling and expression of TMPRSS2, an enzyme important for SARS-CoV-2 host cell internalization.\r\n\r\nHospitalised COVID-19 patients will be randomised (2:1) to enzalutamide plus standard of care vs. standard of care designed to identify superiority.\r\n\r\nIncluded participants, men or women above 50 years of age, must be hospitalised for PCR confirmed COVID-19 symptoms and not in need of immediate mechanical ventilation. Major exclusion criteria are breast-feeding or pregnant women, hormonal treatment for prostate or breast cancer, treatment with immunosuppressive drugs, current symptomatic unstable cardiovascular disease (see Additional file 1 for further details). The trial is registered at Ume\u00e5 University Hospital, Region V\u00e4sterbotten, Sweden and 8 hospitals are approved for inclusion in Sweden.\r\n\r\nPatients randomised to the treatment arm will be treated orally with 160 mg (4x40 mg) enzalutamide (Xtandi\u00ae) daily, for five consecutive days. The study is not placebo controlled. The comparator is standard of care treatment for patients hospitalised with COVID-19.\r\n\r\nThe primary endpoints of the study are (time to) need of mechanical ventilation or discharge from hospital as assessed by a clinical 7-point ordinal scale (up to 30 days after inclusion).\r\n\r\nRandomisation was stratified by center and sex. Each strata was randomized separately with block size six with a 2:1 allocation ratio (enzalutamide + \"standard of care\": \"standard of care\"). The randomisation list, with consecutive subject numbers, was generated by an independent statistician using the PROC PLAN procedure of SAS version 9.4 software (SAS Institute, Inc, Cary, North Carolina) BLINDING (MASKING): This is an open-label trial.\r\n\r\nThe trial is designed to have three phases. The first, an exploration phase of 45 participants (30 treatment and 15 control) will focus on safety and includes a more extensive laboratory assessment as well as more frequent safety evaluation. The second prolongation phase, includes the first 100 participants followed by an interim analysis to define the power of the study. The third phase is the continuation of the study up to maximum 600 participants included in total.\r\n\r\nThe current protocol version is COVIDENZA v2.0 as of September 10, 2020. Recruitment started July 29, 2020 and is presently in safety pause after the first exploration phase. Recruitment is anticipated to be complete by 31 December 2021.\r\n\r\nEudract number 2020-002027-10 ClinicalTrials.gov Identifier: NCT04475601 , registered June 8, 2020 FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.", "doi": "10.1186/s13063-021-05137-4", "pmid": "33726804", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13063-021-05137-4"}, {"db": "pmc", "key": "PMC7961321"}, {"db": "ClinicalTrials.gov", "key": "NCT04475601"}], "notes": [], "created": "2021-03-22T11:34:31.938Z", "modified": "2021-04-26T17:39:07.975Z"}, {"entity": "publication", "iuid": "a7368389e0b64b0f98a017d224b876f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7368389e0b64b0f98a017d224b876f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7368389e0b64b0f98a017d224b876f1"}}, "title": "COVID-19 vaccine guidance for patients with cancer participating in oncology clinical trials.", "authors": [{"family": "Desai", "given": "Aakash", "initials": "A"}, {"family": "Gainor", "given": "Justin F", "initials": "JF"}, {"family": "Hegde", "given": "Aparna", "initials": "A"}, {"family": "Schram", "given": "Alison M", "initials": "AM"}, {"family": "Curigiliano", "given": "Guiseppe", "initials": "G"}, {"family": "Pal", "given": "Sumanta", "initials": "S"}, {"family": "Liu", "given": "Stephen V", "initials": "SV"}, {"family": "Halmos", "given": "Balazs", "initials": "B"}, {"family": "Groisberg", "given": "Roman", "initials": "R"}, {"family": "Grande", "given": "Enrique", "initials": "E"}, {"family": "Dragovich", "given": "Tomislav", "initials": "T"}, {"family": "Matrana", "given": "Marc", "initials": "M"}, {"family": "Agarwal", "given": "Neeraj", "initials": "N"}, {"family": "Chawla", "given": "Sant", "initials": "S"}, {"family": "Kato", "given": "Shumei", "initials": "S"}, {"family": "Morgan", "given": "Gilberto", "initials": "G"}, {"family": "Kasi", "given": "Pashtoon M", "initials": "PM"}, {"family": "Solomon", "given": "Benjamin", "initials": "B"}, {"family": "Loong", "given": "Herbert H", "initials": "HH"}, {"family": "Park", "given": "Haeseong", "initials": "H"}, {"family": "Choueiri", "given": "Toni K", "initials": "TK"}, {"family": "Subbiah", "given": "Ishwaria M", "initials": "IM"}, {"family": "Pemmaraju", "given": "Naveen", "initials": "N"}, {"family": "Subbiah", "given": "Vivek", "initials": "V"}, {"family": "COVID19 and Cancer Clinical Trials Working Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-03-15", "journal": {"title": "Nat Rev Clin Oncol", "issn": "1759-4782", "volume": null, "issue": null, "issn-l": null}, "abstract": "Emerging efficacy data have led to the emergency use authorization or approval of COVID-19 vaccines in several countries worldwide. Most trials of COVID-19 vaccines excluded patients with active malignancies, and thus data on the safety, tolerability and efficacy of the vaccines in patients with cancer are currently limited. Given the risk posed by the COVID-19 pandemic, decisions regarding the use of vaccines against COVID-19 in patients participating in trials of investigational anticancer therapies need to be addressed promptly. Patients should not have to choose between enrolling on oncology clinical trials and receiving a COVID-19 vaccine. Clinical trial sponsors, investigators and treating physicians need operational guidance on COVID-19 vaccination for patients with cancer who are currently enrolled or might seek to enrol in clinical trials. Considering the high morbidity and mortality from COVID-19 in patients with cancer, the benefits of vaccination are likely to far outweigh the risks of vaccine-related adverse events. Herein, we provide operational COVID-19 vaccine guidance for patients participating in oncology clinical trials. In our perspective, continued quality oncological care requires that patients with cancer, including those involved in trials, be prioritized for COVID-19 vaccination, which should not affect trial eligibility.", "doi": "10.1038/s41571-021-00487-z", "pmid": "33723371", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41571-021-00487-z"}], "notes": [], "created": "2021-03-17T07:43:19.672Z", "modified": "2021-03-22T11:39:43.055Z"}, {"entity": "publication", "iuid": "900795e8be414da9a5320172e73e4ed4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/900795e8be414da9a5320172e73e4ed4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/900795e8be414da9a5320172e73e4ed4"}}, "title": "Cardiac arrest in COVID-19: characteristics and outcomes of in- and out-of-hospital cardiac arrest. A report from the Swedish Registry for Cardiopulmonary Resuscitation", "authors": [{"family": "Sultanian", "given": "Pedram", "initials": "P"}, {"family": "Lundgren", "given": "Peter", "initials": "P"}, {"family": "Str\u00f6ms\u00f6e", "given": "Anneli", "initials": "A"}, {"family": "Aune", "given": "Solveig", "initials": "S"}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G"}, {"family": "Hagberg", "given": "Eva", "initials": "E"}, {"family": "Hollenberg", "given": "Jacob", "initials": "J"}, {"family": "Lindqvist", "given": "Jonny", "initials": "J"}, {"family": "Dj\u00e4rv", "given": "Therese", "initials": "T"}, {"family": "Castelheim", "given": "Albert", "initials": "A"}, {"family": "Thor\u00e9n", "given": "Anna", "initials": "A"}, {"family": "Hessulf", "given": "Fredrik", "initials": "F"}, {"family": "Svensson", "given": "Leif", "initials": "L"}, {"family": "Claesson", "given": "Andreas", "initials": "A"}, {"family": "Friberg", "given": "Hans", "initials": "H"}, {"family": "Nordberg", "given": "Per", "initials": "P"}, {"family": "Omerovic", "given": "Elmir", "initials": "E"}, {"family": "Rosengren", "given": "Annika", "initials": "A"}, {"family": "Herlitz", "given": "Johan", "initials": "J"}, {"family": "Rawshani", "given": "Araz", "initials": "A"}], "type": "journal-article", "published": "2021-03-14", "journal": {"title": "Eur Heart J", "issn": "0195-668X", "issn-l": null, "volume": "42", "issue": "11", "pages": "1094-1106"}, "abstract": null, "doi": "10.1093/eurheartj/ehaa1067", "pmid": null, "labels": {"Funder: Hj\u00e4rt-Lungfonden": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-25T17:10:04.621Z", "modified": "2021-06-18T15:26:06.336Z"}, {"entity": "publication", "iuid": "50db707ebaa94540b6b438f659d837fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50db707ebaa94540b6b438f659d837fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50db707ebaa94540b6b438f659d837fa"}}, "title": "Persistence of SARS-CoV-2-specific B and T cell responses in convalescent COVID-19 patients 6-8 months after the infection.", "authors": [{"family": "Sherina", "given": "Natalia", "initials": "N"}, {"family": "Piralla", "given": "Antonio", "initials": "A"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Wan", "given": "Hui", "initials": "H"}, {"family": "Kumagai-Braesch", "given": "Makiko", "initials": "M"}, {"family": "Andr\u00e9ll", "given": "Juni", "initials": "J"}, {"family": "Braesch-Andersen", "given": "Sten", "initials": "S"}, {"family": "Cassaniti", "given": "Irene", "initials": "I"}, {"family": "Percivalle", "given": "Elena", "initials": "E"}, {"family": "Sarasini", "given": "Antonella", "initials": "A"}, {"family": "Bergami", "given": "Federica", "initials": "F"}, {"family": "Di Martino", "given": "Raffaella", "initials": "R"}, {"family": "Colaneri", "given": "Marta", "initials": "M"}, {"family": "Vecchia", "given": "Marco", "initials": "M"}, {"family": "Sambo", "given": "Margherita", "initials": "M"}, {"family": "Zuccaro", "given": "Valentina", "initials": "V"}, {"family": "Bruno", "given": "Raffaele", "initials": "R"}, {"family": "Sachs", "given": "Michele", "initials": "M"}, {"family": "Oggionni", "given": "Tiberio", "initials": "T"}, {"family": "Meloni", "given": "Federica", "initials": "F"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Bertoglio", "given": "Federico", "initials": "F"}, {"family": "Schubert", "given": "Maren", "initials": "M"}, {"family": "Byrne-Steele", "given": "Miranda", "initials": "M"}, {"family": "Han", "given": "Jian", "initials": "J"}, {"family": "Hust", "given": "Michael", "initials": "M"}, {"family": "Xue", "given": "Yintong", "initials": "Y"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}], "type": "journal article", "published": "2021-03-12", "journal": {"title": "Med (N Y)", "issn": "2666-6340", "issn-l": null, "volume": "2", "issue": "3", "pages": "281-295.e4"}, "abstract": "Monitoring the adaptive immune responses during the natural course of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection provides useful information for the development of vaccination strategies against this virus and its emerging variants. We thus profiled the serum anti-SARS-CoV-2 antibody (Ab) levels and specific memory B and T cell responses in convalescent coronavirus disease 2019 (COVID-19) patients.\n\nA total of 119 samples from 88 convalescent donors who experienced mild to critical disease were tested for the presence of elevated anti-spike and anti-receptor binding domain Ab levels over a period of 8 months. In addition, the levels of SARS-CoV-2 neutralizing Abs and specific memory B and T cell responses were tested in a subset of samples.\n\nAnti-SARS-CoV-2 Abs were present in 85% of the samples collected within 4 weeks after the onset of symptoms in COVID-19 patients. Levels of specific immunoglobulin M (IgM)/IgA Abs declined after 1 month, while levels of specific IgG Abs and plasma neutralizing activities remained relatively stable up to 6 months after diagnosis. Anti-SARS-CoV-2 IgG Abs were still present, although at a significantly lower level, in 80% of the samples collected at 6-8 months after symptom onset. SARS-CoV-2-specific memory B and T cell responses developed with time and were persistent in all of the patients followed up for 6-8 months.\n\nOur data suggest that protective adaptive immunity following natural infection of SARS-CoV-2 may persist for at least 6-8 months, regardless of disease severity. Development of medium- or long-term protective immunity through vaccination may thus be possible.\n\nThis project was supported by the European Union's Horizon 2020 research and innovation programme (ATAC, no. 101003650), the Italian Ministry of Health (Ricerca Finalizzata grant no. GR-2013-02358399), the Center for Innovative Medicine, and the Swedish Research Council. J.A. was supported by the SciLifeLab/KAW national COVID-19 research program project grant 2020.", "doi": "10.1016/j.medj.2021.02.001", "pmid": "33589885", "labels": {"Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Research Area: High-throughput and high-content serology": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S2666-6340(21)00038-6"}, {"db": "pmc", "key": "PMC7874960"}], "notes": [], "created": "2021-02-17T14:55:48.819Z", "modified": "2021-12-12T18:07:23.858Z"}, {"entity": "publication", "iuid": "79aa0ace4ea74d2080d6c5bdc0c42be7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79aa0ace4ea74d2080d6c5bdc0c42be7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79aa0ace4ea74d2080d6c5bdc0c42be7"}}, "title": "Oxygen provision to severely ill COVID-19 patients at the peak of the 2020 pandemic in a Swedish district hospital", "authors": [{"family": "Hvarfner", "given": "Anna", "initials": "A"}, {"family": "Al-Djaber", "given": "Ahmed", "initials": "A"}, {"family": "Ekstrom", "given": "Hampus", "initials": "H"}, {"family": "Enarsson", "given": "Malin", "initials": "M"}, {"family": "Castegren", "given": "Markus", "initials": "M"}, {"family": "Baker", "given": "Tim", "initials": "T"}, {"family": "Schell", "given": "Carl Otto", "initials": "CO"}], "type": "posted-content", "published": "2021-03-12", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.11.21253350", "pmid": null, "labels": {"Category: Health": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-03-25T14:04:28.506Z", "modified": "2021-03-31T08:20:11.539Z"}, {"entity": "publication", "iuid": "bb5ddc2c0e004a5a8558b2c87b6026d3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb5ddc2c0e004a5a8558b2c87b6026d3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb5ddc2c0e004a5a8558b2c87b6026d3"}}, "title": "Mapping the human genetic architecture of COVID-19 by worldwide meta-analysis", "authors": [{"family": null, "given": "", "initials": ""}, {"family": "Ganna", "given": "Andrea", "initials": "A", "orcid": "0000-0002-8147-240X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b7f6041889a4ebbab284d4ea5647a50.json"}}], "type": "posted-content", "published": "2021-03-12", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.10.21252820", "pmid": null, "labels": {"Category: Genomics & transcriptomics": null, "Type: Preprint": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "URL", "key": "https://www.covid19hg.org/results/r5/", "description": "Summary statistics generated by COVID-19 HGI"}, {"db": "URL", "key": "https://github.com/marcoralab/MRcovid", "description": "Code for Mendelian randomization and genetic correlation pipeline"}, {"db": "URL", "key": "https://github.com/covid19-hg/", "description": "Code for summary statistics liftover and meta-analysis and PCA pipeline"}], "notes": [], "created": "2021-03-15T17:29:56.885Z", "modified": "2022-02-06T17:38:55.641Z"}, {"entity": "publication", "iuid": "051c1aac317d46c08affde26d18af82b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/051c1aac317d46c08affde26d18af82b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/051c1aac317d46c08affde26d18af82b"}}, "title": "Indoor Model Simulation for COVID-19 Transport and Exposure.", "authors": [{"family": "Hussein", "given": "Tareq", "initials": "T"}, {"family": "L\u00f6ndahl", "given": "Jakob", "initials": "J"}, {"family": "Thuresson", "given": "Sara", "initials": "S"}, {"family": "Alsved", "given": "Malin", "initials": "M"}, {"family": "Al-Hunaiti", "given": "Afnan", "initials": "A"}, {"family": "Saksela", "given": "Kalle", "initials": "K"}, {"family": "Aqel", "given": "Hazem", "initials": "H"}, {"family": "Junninen", "given": "Heikki", "initials": "H"}, {"family": "Mahura", "given": "Alexander", "initials": "A"}, {"family": "Kulmala", "given": "Markku", "initials": "M"}], "type": "journal article", "published": "2021-03-12", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "6", "pages": null}, "abstract": "Transmission of respiratory viruses is a complex process involving emission, deposition in the airways, and infection. Inhalation is often the most relevant transmission mode in indoor environments. For severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the risk of inhalation transmission is not yet fully understood. Here, we used an indoor aerosol model combined with a regional inhaled deposited dose model to examine the indoor transport of aerosols from an infected person with novel coronavirus disease (COVID-19) to a susceptible person and assess the potential inhaled dose rate of particles. Two scenarios with different ventilation rates were compared, as well as adult female versus male recipients. Assuming a source strength of 10 viruses/s, in a tightly closed room with poor ventilation (0.5 h -1), the respiratory tract deposited dose rate was 140-350 and 100-260 inhaled viruses/hour for males and females; respectively. With ventilation at 3 h-1 the dose rate was only 30-90 viruses/hour. Correcting for the half-life of SARS-CoV-2 in air, these numbers are reduced by a factor of 1.2-2.2 for poorly ventilated rooms and 1.1-1.4 for well-ventilated rooms. Combined with future determinations of virus emission rates, the size distribution of aerosols containing the virus, and the infectious dose, these results could play an important role in understanding the full picture of potential inhalation transmission in indoor environments.", "doi": "10.3390/ijerph18062927", "pmid": "33809366", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Public Health": null, "Funder: H2020": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pii", "key": "ijerph18062927"}], "notes": [], "created": "2021-04-06T10:28:30.739Z", "modified": "2021-06-18T15:24:59.028Z"}, {"entity": "publication", "iuid": "57b0f4e9731f4829b69f86301d0eb285", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/57b0f4e9731f4829b69f86301d0eb285.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/57b0f4e9731f4829b69f86301d0eb285"}}, "title": "Does reactivation of cytomegalovirus contribute to severe COVID-19 disease?", "authors": [{"family": "S\u00f6derberg-Naucl\u00e9r", "given": "Cecilia", "initials": "C"}], "type": "letter", "published": "2021-03-12", "journal": {"title": "Immun Ageing", "issn": "1742-4933", "volume": "18", "issue": "1", "pages": "12", "issn-l": null}, "abstract": "The majority of people infected with SARS-CoV-2 are asymptomatic or have mild to moderate symptoms. However, for unknown reasons, about 15 % have severe pneumonia requiring hospital care and oxygen support, and about 5 % develop acute respiratory distress syndrome, septic shock, and multiorgan failure that result in a high mortality rate. The risk of severe COVID-19 is highest among those who are over 70 years of age. Why severe COVID-19 develops in some people but not others is not understood. Could some cases involve reactivation of latent cytomegalovirus (CMV)?", "doi": "10.1186/s12979-021-00218-z", "pmid": "33712035", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12979-021-00218-z"}, {"db": "pmc", "key": "PMC7952506"}], "notes": [], "created": "2021-03-17T07:17:39.389Z", "modified": "2021-03-17T07:17:39.410Z"}, {"entity": "publication", "iuid": "0fda30da2de8474d9d7951b107e01343", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0fda30da2de8474d9d7951b107e01343.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0fda30da2de8474d9d7951b107e01343"}}, "title": "Disparities in COVID-19 deaths by country of birth in Stockholm, Sweden: A total population based cohort study.", "authors": [{"family": "Rostila", "given": "Mikael", "initials": "M"}, {"family": "Cederstr\u00f6m", "given": "Agneta", "initials": "A"}, {"family": "Wallace", "given": "Matthew", "initials": "M"}, {"family": "Brand\u00e9n", "given": "Maria", "initials": "M"}, {"family": "Malmberg", "given": "Bo", "initials": "B"}, {"family": "Andersson", "given": "Gunnar", "initials": "G"}], "type": "journal article", "published": "2021-03-12", "journal": {"title": "Am J Epidemiol", "issn": "1476-6256", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Preliminary evidence points to higher morbidity and mortality of COVID-19 in certain racial and ethnic groups but population-based studies using micro-level data are so far lacking. A register-based cohort including all adults living in Stockholm, Sweden (n=1,778,670) between January 31st (date of first confirmed case of COVID-19) and May 4th 2020 was utilized. Poisson regressions with region/country of birth as exposure and underlying cause of death by COVID-19 as outcome was performed, estimating relative risks (RR) and confidence intervals (CI). Migrants from Middle-Eastern countries (RR 3.2, 95% CI: 2.6-3.8), Africa (RR 3.0, 95% CI: 2.2-4.3) and the Nordic countries (RR 1.5, 95% CI: 1.2-1.8) had higher mortality in COVID-19 when compared to Swedish born. Especially high mortality risks from COVID-19 was found among individuals born in Somalia, Lebanon, Syria, Turkey, Iran and Iraq. Socioeconomic status, number of working age household members and neighborhood population density attenuated up to half of the increased COVID-19 mortality risks among foreign born. Disadvantaged socioeconomic and living conditions may increase infection rates in migrants and contribute to their higher COVID-19 mortality risk.", "doi": "10.1093/aje/kwab057", "pmid": "33710317", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6168677"}], "notes": [], "created": "2021-03-17T07:16:08.894Z", "modified": "2021-06-18T15:22:46.753Z"}, {"entity": "publication", "iuid": "ed5b25234cba4f13b74f1d73fda2a894", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed5b25234cba4f13b74f1d73fda2a894.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed5b25234cba4f13b74f1d73fda2a894"}}, "title": "Could a good night's sleep improve COVID-19 vaccine efficacy?", "authors": [{"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J"}], "type": "journal article", "published": "2021-03-12", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "volume": null, "issue": null, "issn-l": "2213-2600"}, "abstract": null, "doi": "10.1016/S2213-2600(21)00126-0", "pmid": "33721558", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(21)00126-0"}], "notes": [], "created": "2021-03-17T07:45:00.431Z", "modified": "2021-03-22T11:44:11.630Z"}, {"entity": "publication", "iuid": "bfc7cd9b29f3455f9279026840d26993", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bfc7cd9b29f3455f9279026840d26993.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bfc7cd9b29f3455f9279026840d26993"}}, "title": "[Tracheotomy earlier than recommended among patients with Covid-19].", "authors": [{"family": "Nihl\u00e9n", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Odhagen", "given": "Erik", "initials": "E"}, {"family": "Lindell", "given": "Ellen", "initials": "E"}], "type": "journal article", "published": "2021-03-11", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "volume": "118", "issue": null, "issn-l": "0023-7205"}, "abstract": "The outbreak of SARS-CoV-2 has led to a sharp rise in intensive care unit (ICU) admissions and consequently a need to perform tracheotomies on patients with Covid-19. A number of guidelines have been published with recommendations for the timing of tracheostomy in Covid-19 patients, suggesting tracheotomy should be delayed until day 14-21 of mechanical ventilation. We present the first 66 patients treated in the ICU at S\u00f6dra \u00c4lvsborg hospital in Sweden as a result of Covid-19. A total of 29 patients received a tracheostomy, median time 9 days post oral intubation, which is earlier than recommended. The mortality rate was 21%, which is slightly lower than reported from The Swedish Intensive Care Registry (25%). None of the doctors performing tracheotomies developed Covid-19 linked to the tracheotomy procedure.", "doi": null, "pmid": "33709387", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "20232"}], "notes": [], "created": "2021-03-17T07:18:22.056Z", "modified": "2021-03-17T07:41:15.135Z"}, {"entity": "publication", "iuid": "08edf7c7a48448198e50b7c786f8cb50", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/08edf7c7a48448198e50b7c786f8cb50.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/08edf7c7a48448198e50b7c786f8cb50"}}, "title": "The battle for COVID-19 vaccines highlights the need for a new global governance mechanism.", "authors": [{"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM"}, {"family": "Berggren", "given": "Camilla", "initials": "C"}, {"family": "Tomson", "given": "G\u00f6ran", "initials": "G"}, {"family": "Gostin", "given": "Lawrence O", "initials": "LO"}, {"family": "Friberg", "given": "Peter", "initials": "P"}, {"family": "Ottersen", "given": "Ole Petter", "initials": "OP"}], "type": "letter", "published": "2021-03-11", "journal": {"title": "Nat Med", "issn": "1546-170X", "volume": null, "issue": null, "issn-l": "1078-8956"}, "abstract": null, "doi": "10.1038/s41591-021-01288-8", "pmid": "33707776", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-021-01288-8"}], "notes": [], "created": "2021-03-17T07:20:39.660Z", "modified": "2021-03-17T07:20:39.669Z"}, {"entity": "publication", "iuid": "de451ac94d164bf5b45bf034a5c04d1c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/de451ac94d164bf5b45bf034a5c04d1c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/de451ac94d164bf5b45bf034a5c04d1c"}}, "title": "Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers.", "authors": [{"family": "Danlos", "given": "Fran\u00e7ois-Xavier", "initials": "FX"}, {"family": "Grajeda-Iglesias", "given": "Claudia", "initials": "C"}, {"family": "Durand", "given": "Sylv\u00e8re", "initials": "S"}, {"family": "Sauvat", "given": "Allan", "initials": "A"}, {"family": "Roumier", "given": "Mathilde", "initials": "M"}, {"family": "Cantin", "given": "Delphine", "initials": "D"}, {"family": "Colomba", "given": "Emeline", "initials": "E"}, {"family": "Rohmer", "given": "Julien", "initials": "J"}, {"family": "Pommeret", "given": "Fanny", "initials": "F"}, {"family": "Baciarello", "given": "Giulia", "initials": "G"}, {"family": "Willekens", "given": "Christophe", "initials": "C"}, {"family": "Vasse", "given": "Marc", "initials": "M"}, {"family": "Griscelli", "given": "Frank", "initials": "F"}, {"family": "Fahrner", "given": "Jean-Eudes", "initials": "JE"}, {"family": "Goubet", "given": "Anne-Ga\u00eblle", "initials": "AG"}, {"family": "Dubuisson", "given": "Agathe", "initials": "A"}, {"family": "Derosa", "given": "Lisa", "initials": "L"}, {"family": "Nirmalathasan", "given": "Nitharsshini", "initials": "N"}, {"family": "Bredel", "given": "Delphine", "initials": "D"}, {"family": "Mouraud", "given": "S\u00e9verine", "initials": "S"}, {"family": "Pradon", "given": "Caroline", "initials": "C"}, {"family": "Stoclin", "given": "Annabelle", "initials": "A"}, {"family": "Rozenberg", "given": "Flore", "initials": "F"}, {"family": "Duchemin", "given": "J\u00e9r\u00f4me", "initials": "J"}, {"family": "Jourdi", "given": "Georges", "initials": "G"}, {"family": "Ellouze", "given": "Syrine", "initials": "S"}, {"family": "Levavasseur", "given": "Fran\u00e7oise", "initials": "F"}, {"family": "Albig\u00e8s", "given": "Laurence", "initials": "L"}, {"family": "Soria", "given": "Jean-Charles", "initials": "JC"}, {"family": "Barlesi", "given": "Fabrice", "initials": "F"}, {"family": "Solary", "given": "Eric", "initials": "E"}, {"family": "Andr\u00e9", "given": "Fabrice", "initials": "F"}, {"family": "P\u00e8ne", "given": "Fr\u00e9d\u00e9ric", "initials": "F"}, {"family": "Ackerman", "given": "F\u00e9lix", "initials": "F"}, {"family": "Mouthon", "given": "Luc", "initials": "L"}, {"family": "Zitvogel", "given": "Laurence", "initials": "L"}, {"family": "Marabelle", "given": "Aur\u00e9lien", "initials": "A"}, {"family": "Michot", "given": "Jean-Marie", "initials": "JM"}, {"family": "Fontenay", "given": "Michaela", "initials": "M"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}], "type": "journal article", "published": "2021-03-11", "journal": {"title": "Cell Death Dis", "issn": "2041-4889", "volume": "12", "issue": "3", "pages": "258", "issn-l": null}, "abstract": "The circulating metabolome provides a snapshot of the physiological state of the organism responding to pathogenic challenges. Here we report alterations in the plasma metabolome reflecting the clinical presentation of COVID-19 patients with mild (ambulatory) diseases, moderate disease (radiologically confirmed pneumonitis, hospitalization and oxygen therapy), and critical disease (in intensive care). This analysis revealed major disease- and stage-associated shifts in the metabolome, meaning that at least 77 metabolites including amino acids, lipids, polyamines and sugars, as well as their derivatives, were altered in critical COVID-19 patient's plasma as compared to mild COVID-19 patients. Among a uniformly moderate cohort of patients who received tocilizumab, only 10 metabolites were different among individuals with a favorable evolution as compared to those who required transfer into the intensive care unit. The elevation of one single metabolite, anthranilic acid, had a poor prognostic value, correlating with the maintenance of high interleukin-10 and -18 levels. Given that products of the kynurenine pathway including anthranilic acid have immunosuppressive properties, we speculate on the therapeutic utility to inhibit the rate-limiting enzymes of this pathway including indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase.", "doi": "10.1038/s41419-021-03540-y", "pmid": "33707411", "labels": {"Category: Drug Discovery": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41419-021-03540-y"}, {"db": "pmc", "key": "PMC7948172"}, {"db": "URL", "key": "https://doi.org/10.1038/s41419-021-03540-y", "description": "All metabolomics data (supplementary tables)"}], "notes": [], "created": "2021-03-17T07:10:40.858Z", "modified": "2021-11-18T13:09:56.552Z"}, {"entity": "publication", "iuid": "910730ae686542e69773578ef3922045", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/910730ae686542e69773578ef3922045.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/910730ae686542e69773578ef3922045"}}, "title": "Interventions for treatment of COVID-19: Second edition of a living systematic review with meta-analyses and trial sequential analyses (The LIVING Project).", "authors": [{"family": "Juul", "given": "Sophie", "initials": "S"}, {"family": "Nielsen", "given": "Emil Eik", "initials": "EE"}, {"family": "Feinberg", "given": "Joshua", "initials": "J"}, {"family": "Siddiqui", "given": "Faiza", "initials": "F"}, {"family": "J\u00f8rgensen", "given": "Caroline Kamp", "initials": "CK"}, {"family": "Barot", "given": "Emily", "initials": "E"}, {"family": "Holgersson", "given": "Johan", "initials": "J"}, {"family": "Nielsen", "given": "Niklas", "initials": "N"}, {"family": "Bentzer", "given": "Peter", "initials": "P"}, {"family": "Veroniki", "given": "Areti Angeliki", "initials": "AA"}, {"family": "Thabane", "given": "Lehana", "initials": "L"}, {"family": "Bu", "given": "Fanlong", "initials": "F"}, {"family": "Klingenberg", "given": "Sarah", "initials": "S"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Jakobsen", "given": "Janus Christian", "initials": "JC"}], "type": "journal article", "published": "2021-03-11", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "3", "pages": "e0248132", "issn-l": "1932-6203"}, "abstract": "COVID-19 is a rapidly spreading disease that has caused extensive burden to individuals, families, countries, and the world. Effective treatments of COVID-19 are urgently needed. This is the second edition of a living systematic review of randomized clinical trials assessing the effects of all treatment interventions for participants in all age groups with COVID-19.\n\nWe planned to conduct aggregate data meta-analyses, trial sequential analyses, network meta-analysis, and individual patient data meta-analyses. Our systematic review was based on PRISMA and Cochrane guidelines, and our eight-step procedure for better validation of clinical significance of meta-analysis results. We performed both fixed-effect and random-effects meta-analyses. Primary outcomes were all-cause mortality and serious adverse events. Secondary outcomes were admission to intensive care, mechanical ventilation, renal replacement therapy, quality of life, and non-serious adverse events. According to the number of outcome comparisons, we adjusted our threshold for significance to p = 0.033. We used GRADE to assess the certainty of evidence. We searched relevant databases and websites for published and unpublished trials until November 2, 2020. Two reviewers independently extracted data and assessed trial methodology. We included 82 randomized clinical trials enrolling a total of 40,249 participants. 81 out of 82 trials were at overall high risk of bias. Meta-analyses showed no evidence of a difference between corticosteroids versus control on all-cause mortality (risk ratio [RR] 0.89; 95% confidence interval [CI] 0.79 to 1.00; p = 0.05; I2 = 23.1%; eight trials; very low certainty), on serious adverse events (RR 0.89; 95% CI 0.80 to 0.99; p = 0.04; I2 = 39.1%; eight trials; very low certainty), and on mechanical ventilation (RR 0.86; 95% CI 0.55 to 1.33; p = 0.49; I2 = 55.3%; two trials; very low certainty). The fixed-effect meta-analyses showed indications of beneficial effects. Trial sequential analyses showed that the required information size for all three analyses was not reached. Meta-analysis (RR 0.93; 95% CI 0.82 to 1.07; p = 0.31; I2 = 0%; four trials; moderate certainty) and trial sequential analysis (boundary for futility crossed) showed that we could reject that remdesivir versus control reduced the risk of death by 20%. Meta-analysis (RR 0.82; 95% CI 0.68 to 1.00; p = 0.05; I2 = 38.9%; four trials; very low certainty) and trial sequential analysis (required information size not reached) showed no evidence of difference between remdesivir versus control on serious adverse events. Fixed-effect meta-analysis showed indications of a beneficial effect of remdesivir on serious adverse events. Meta-analysis (RR 0.40; 95% CI 0.19 to 0.87; p = 0.02; I2 = 0%; two trials; very low certainty) showed evidence of a beneficial effect of intravenous immunoglobulin versus control on all-cause mortality, but trial sequential analysis (required information size not reached) showed that the result was severely underpowered to confirm or reject realistic intervention effects. Meta-analysis (RR 0.63; 95% CI 0.35 to 1.14; p = 0.12; I2 = 77.4%; five trials; very low certainty) and trial sequential analysis (required information size not reached) showed no evidence of a difference between tocilizumab versus control on serious adverse events. Fixed-effect meta-analysis showed indications of a beneficial effect of tocilizumab on serious adverse events. Meta-analysis (RR 0.70; 95% CI 0.51 to 0.96; p = 0.02; I2 = 0%; three trials; very low certainty) showed evidence of a beneficial effect of tocilizumab versus control on mechanical ventilation, but trial sequential analysis (required information size not reached) showed that the result was severely underpowered to confirm of reject realistic intervention effects. Meta-analysis (RR 0.32; 95% CI 0.15 to 0.69; p < 0.00; I2 = 0%; two trials; very low certainty) showed evidence of a beneficial effect of bromhexine versus standard care on non-serious adverse events, but trial sequential analysis (required information size not reached) showed that the result was severely underpowered to confirm or reject realistic intervention effects. Meta-analyses and trial sequential analyses (boundary for futility crossed) showed that we could reject that hydroxychloroquine versus control reduced the risk of death and serious adverse events by 20%. Meta-analyses and trial sequential analyses (boundary for futility crossed) showed that we could reject that lopinavir-ritonavir versus control reduced the risk of death, serious adverse events, and mechanical ventilation by 20%. All remaining outcome comparisons showed that we did not have enough information to confirm or reject realistic intervention effects. Nine single trials showed statistically significant results on our outcomes, but were underpowered to confirm or reject realistic intervention effects. Due to lack of data, it was not relevant to perform network meta-analysis or possible to perform individual patient data meta-analyses.\n\nNo evidence-based treatment for COVID-19 currently exists. Very low certainty evidence indicates that corticosteroids might reduce the risk of death, serious adverse events, and mechanical ventilation; that remdesivir might reduce the risk of serious adverse events; that intravenous immunoglobin might reduce the risk of death and serious adverse events; that tocilizumab might reduce the risk of serious adverse events and mechanical ventilation; and that bromhexine might reduce the risk of non-serious adverse events. More trials with low risks of bias and random errors are urgently needed. This review will continuously inform best practice in treatment and clinical research of COVID-19.\n\nPROSPERO CRD42020178787.", "doi": "10.1371/journal.pone.0248132", "pmid": "33705495", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-38879"}], "notes": [], "created": "2021-03-12T07:06:25.255Z", "modified": "2021-03-12T07:06:25.266Z"}, {"entity": "publication", "iuid": "e4441b5f42514f278ec262f36dd23c9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e4441b5f42514f278ec262f36dd23c9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e4441b5f42514f278ec262f36dd23c9c"}}, "title": "Awake Proning as an Adjunctive Therapy for Refractory Hypoxemia in Non-Intubated Patients with COVID-19 Acute Respiratory Failure: Guidance from an International Group of Healthcare Workers.", "authors": [{"family": "Stilma", "given": "Willemke", "initials": "W"}, {"family": "\u00c5kerman", "given": "Eva", "initials": "E"}, {"family": "Artigas", "given": "Antonio", "initials": "A"}, {"family": "Bentley", "given": "Andrew", "initials": "A"}, {"family": "Bos", "given": "Lieuwe D", "initials": "LD"}, {"family": "Bosman", "given": "Thomas J C", "initials": "TJC"}, {"family": "de Bruin", "given": "Hendrik", "initials": "H"}, {"family": "Brummaier", "given": "Tobias", "initials": "T"}, {"family": "Buiteman-Kruizinga", "given": "Laura A", "initials": "LA"}, {"family": "Carc\u00f2", "given": "Francesco", "initials": "F"}, {"family": "Chesney", "given": "Gregg", "initials": "G"}, {"family": "Chu", "given": "Cindy", "initials": "C"}, {"family": "Dark", "given": "Paul", "initials": "P"}, {"family": "Dondorp", "given": "Arjen M", "initials": "AM"}, {"family": "Gijsbers", "given": "Harm J H", "initials": "HJH"}, {"family": "Gilder", "given": "Mary Ellen", "initials": "ME"}, {"family": "Grieco", "given": "Domenico L", "initials": "DL"}, {"family": "Inglis", "given": "Rebecca", "initials": "R"}, {"family": "Laffey", "given": "John G", "initials": "JG"}, {"family": "Landoni", "given": "Giovanni", "initials": "G"}, {"family": "Lu", "given": "Weihua", "initials": "W"}, {"family": "Maduro", "given": "Lisa M N", "initials": "LMN"}, {"family": "McGready", "given": "Rose", "initials": "R"}, {"family": "McNicholas", "given": "Bairbre", "initials": "B"}, {"family": "de Mendoza", "given": "Diego", "initials": "D"}, {"family": "Morales-Quinteros", "given": "Luis", "initials": "L"}, {"family": "Nosten", "given": "Francois", "initials": "F"}, {"family": "Papali", "given": "Alfred", "initials": "A"}, {"family": "Paternoster", "given": "Gianluca", "initials": "G"}, {"family": "Paulus", "given": "Frederique", "initials": "F"}, {"family": "Pisani", "given": "Luigi", "initials": "L"}, {"family": "Prud'homme", "given": "Eloi", "initials": "E"}, {"family": "Ricard", "given": "Jean-Damien", "initials": "JD"}, {"family": "Roca", "given": "Oriol", "initials": "O"}, {"family": "Sartini", "given": "Chiara", "initials": "C"}, {"family": "Scaravilli", "given": "Vittorio", "initials": "V"}, {"family": "Schultz", "given": "Marcus J", "initials": "MJ"}, {"family": "Sivakorn", "given": "Chaisith", "initials": "C"}, {"family": "Spronk", "given": "Peter E", "initials": "PE"}, {"family": "Sztajnbok", "given": "Jaques", "initials": "J"}, {"family": "Trigui", "given": "Youssef", "initials": "Y"}, {"family": "Vollman", "given": "Kathleen M", "initials": "KM"}, {"family": "van der Woude", "given": "Margaretha C E", "initials": "MCE"}], "type": "journal article", "published": "2021-03-11", "journal": {"title": "Am J Trop Med Hyg", "issn": "1476-1645", "volume": null, "issue": null, "issn-l": "0002-9637"}, "abstract": "Non-intubated patients with acute respiratory failure due to COVID-19 could benefit from awake proning. Awake proning is an attractive intervention in settings with limited resources, as it comes with no additional costs. However, awake proning remains poorly used probably because of unfamiliarity and uncertainties regarding potential benefits and practical application. To summarize evidence for benefit and to develop a set of pragmatic recommendations for awake proning in patients with COVID-19 pneumonia, focusing on settings where resources are limited, international healthcare professionals from high and low- and middle-income countries (LMICs) with known expertise in awake proning were invited to contribute expert advice. A growing number of observational studies describe the effects of awake proning in patients with COVID-19 pneumonia in whom hypoxemia is refractory to simple measures of supplementary oxygen. Awake proning improves oxygenation in most patients, usually within minutes, and reduces dyspnea and work of breathing. The effects are maintained for up to 1 hour after turning back to supine, and mostly disappear after 6-12 hours. In available studies, awake proning was not associated with a reduction in the rate of intubation for invasive ventilation. Awake proning comes with little complications if properly implemented and monitored. Pragmatic recommendations including indications and contraindications were formulated and adjusted for resource-limited settings. Awake proning, an adjunctive treatment for hypoxemia refractory to supplemental oxygen, seems safe in non-intubated patients with COVID-19 acute respiratory failure. We provide pragmatic recommendations including indications and contraindications for the use of awake proning in LMICs.", "doi": "10.4269/ajtmh.20-1445", "pmid": "33705348", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "tpmd201445"}, {"db": "pmc", "key": "PMC8103477"}], "notes": [], "created": "2021-03-12T07:05:39.237Z", "modified": "2021-11-18T12:57:03.738Z"}, {"entity": "publication", "iuid": "02ac2f6d92cb43919788a8738c0d2c7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02ac2f6d92cb43919788a8738c0d2c7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02ac2f6d92cb43919788a8738c0d2c7a"}}, "title": "Analysis of the early COVID-19 epidemic curve in Germany by regression models with change points.", "authors": [{"family": "K\u00fcchenhoff", "given": "Helmut", "initials": "H"}, {"family": "G\u00fcnther", "given": "Felix", "initials": "F"}, {"family": "H\u00f6hle", "given": "Michael", "initials": "M"}, {"family": "Bender", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2021-03-11", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "issn-l": null, "volume": null, "issue": null, "pages": "1-17"}, "abstract": null, "doi": "10.1017/S0950268821000558", "pmid": "33691815", "labels": {"Category: Public Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0950268821000558"}], "notes": [], "created": "2021-03-12T06:11:13.310Z", "modified": "2021-06-18T15:03:05.817Z"}, {"entity": "publication", "iuid": "506375d9c20e4838a66749414bb9fd7f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/506375d9c20e4838a66749414bb9fd7f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/506375d9c20e4838a66749414bb9fd7f"}}, "title": "Dangerous liaisons: an online experiment on the role of scientific experts and politicians in ensuring public support for anti-COVID measures.", "authors": [{"family": "Farjam", "given": "Mike", "initials": "M"}, {"family": "Bianchi", "given": "Federico", "initials": "F"}, {"family": "Squazzoni", "given": "Flaminio", "initials": "F"}, {"family": "Bravo", "given": "Giangiacomo", "initials": "G"}], "type": "journal article", "published": "2021-03-10", "journal": {"title": "R Soc Open Sci", "issn": "2054-5703", "volume": "8", "issue": "3", "pages": "201310", "issn-l": null}, "abstract": "The effectiveness of public health measures to prevent COVID-19 contagion has required less vulnerable citizens to pay an individual cost in terms of personal liberty infringement to protect more vulnerable groups. However, the close relationship between scientific experts and politicians in providing information on COVID-19 measures makes it difficult to understand which communication source was more effective in increasing pro-social behaviour. Here, we present an online experiment performed in May 2020, during the first wave of the pandemic on 1131 adult residents in Lombardy, Italy, one of the world's hardest hit regions. Results showed that when scientific experts recommended anti-contagion measures, participants were more sensitive to pro-social motivations, unlike whenever these measures were recommended by politicians and scientific experts together. Our findings suggest the importance of trusted sources in public communication during a pandemic.", "doi": "10.1098/rsos.201310", "pmid": "33959315", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "rsos201310"}, {"db": "pmc", "key": "PMC8074882"}], "notes": [], "created": "2021-05-17T19:07:13.485Z", "modified": "2021-05-17T19:07:13.496Z"}, {"entity": "publication", "iuid": "7eb3ba1ca5864d3e8b7a01c85b5ca3ac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7eb3ba1ca5864d3e8b7a01c85b5ca3ac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7eb3ba1ca5864d3e8b7a01c85b5ca3ac"}}, "title": "COVID-19 Antibody Testing of Patients Admitted to the ICU by a Novel, Point-of-Care Assay, and the Relationship to Survival", "authors": [{"family": "Casswell", "given": "Stacey", "initials": "S"}, {"family": "Eriksson", "given": "Ann Katrin", "initials": "AK"}, {"family": "Moberg", "given": "Lena", "initials": "L"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Marshall", "given": "Fiona", "initials": "F"}, {"family": "Venge", "given": "Per", "initials": "P"}], "type": "posted-content", "published": "2021-03-10", "journal": {"title": "Research Square", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Diagnosing persons infected by COVID-19 is key to the control of the pandemic. It has, however, become increasingly important to identify those who have had the infection by measurement of circulating antibodies against Sars-COV-2 of the IgM and IgG type. In this report we show the development of a rapid and sensitive point-of-care assay for the measurement of IgG antibodies against the two spike proteins, S1 and S2, of the Sars-COV-2 virus.\r\nMethod\r\nThe AgPlus electrochemical technology was applied and the S1 and S2 proteins were biotinylated and immobilized onto streptavidin coated magnetic particles as the capture component of the assay. The IgG antibodies bound to the particles were detected by anti-human IgG and the signal expressed as nC (nano Coulomb). Assay time was <10 min.\r\nResults\r\nPlasma (n=211) from 117 SARS-Cov-2 PCR positive patients and from 78 persons with samples taken before the COVID-19 pandemic were analysed. The sensitivity and specificity of the assay were 91.9% and 100%, respectively. The assay was highly correlated to a predicate and FDA-approved IgG antibody ELISA (r=0.81). The IgG response was significantly lower in patients who died during their ICU stay.\r\nConclusions\r\nA poor IgG response after a COVID-19 infection is a serious risk factor as to death. A sensitive, rapid and accurate IgG antibody POC assay should be useful in the daily management and evaluation of COVID-19 infected patients.", "doi": "10.21203/rs.3.rs-289303/v1", "pmid": null, "labels": {"Category: Proteins": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Preprint": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT04316884", "description": null}], "notes": [], "created": "2021-03-16T07:15:17.244Z", "modified": "2021-05-06T05:38:49.997Z"}, {"entity": "publication", "iuid": "dda2feafd8ce45c5b77c4b517d6b0d07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dda2feafd8ce45c5b77c4b517d6b0d07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dda2feafd8ce45c5b77c4b517d6b0d07"}}, "title": "Recommendations for the use of COVID-19 vaccines in patients with immune-mediated kidney diseases.", "authors": [{"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Anders", "given": "Hans-Joachim", "initials": "HJ"}, {"family": "Fernandez-Ju\u00e1rez", "given": "Gema Maria", "initials": "GM"}, {"family": "Floege", "given": "J\u00fcrgen", "initials": "J"}, {"family": "Goumenos", "given": "Dimitrios", "initials": "D"}, {"family": "Segelmark", "given": "M\u00e5rten", "initials": "M"}, {"family": "Tesar", "given": "Vladimir", "initials": "V"}, {"family": "Turkmen", "given": "Kultigin", "initials": "K"}, {"family": "van Kooten", "given": "Cees", "initials": "C"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Immunonephrology Working Group of the ERA-EDTA (European Renal Association \u2013 European Dialysis, Transplant Association)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-03-09", "journal": {"title": "Nephrol Dial Transplant", "issn": "1460-2385", "volume": null, "issue": null, "issn-l": "0931-0509"}, "abstract": "Coronavirus Disease 19 (COVID-19) vaccine platforms are becoming available and are the most promising strategy to curb the spread of SARS-CoV-2 infections. However, numerous uncertainties exist regarding the pros and cons of vaccination, especially in patients with (immune-mediated) kidney diseases on immunosuppressive drugs. Here, members of the Immunonephrology Working Group (IWG) of the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) discuss thirteen frequently-asked questions regarding safety and efficacy of the most promising vaccine candidates. Post-marketing surveillance should be performed to estimate the rate of vaccine response (humoral and cellular) of different vaccine platforms, and surveillance of disease activity following administration of COVID-19 vaccines. Some of the candidates induce signaling pathways which also promote autoimmune kidney diseases, e.g. type I interferons in systemic lupus erythematosus. Efficacy estimates would thus far favor the use of selected COVID-19 vaccines, such as BNT162b2, mRNA-1273 or Gam-COVID-Vac. Humoral immune response after vaccination should be monitored using appropriate assays. Even in the absence of neutralizing antibodies patients might be protected by a sufficient cellular immune response capable to reduce severity of COVID-19. A reduced vaccine response after the use of CD20-depleting agents is anticipated, and it is particularly important to discuss strategies to improve vaccine response with these patients. Distancing and shielding measures remain important as not all vaccines fully protect from coronavirus infection. In-depth information about the most pressing vaccine questions is essential to reduce vaccine hesitancy of patients.", "doi": "10.1093/ndt/gfab064", "pmid": "33693778", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6163301"}, {"db": "pmc", "key": "PMC7989374"}], "notes": [], "created": "2021-03-12T06:41:55.287Z", "modified": "2021-11-18T12:53:07.877Z"}, {"entity": "publication", "iuid": "65b3cf84cf1c4adabcf5084d92f886fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65b3cf84cf1c4adabcf5084d92f886fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65b3cf84cf1c4adabcf5084d92f886fd"}}, "title": "Association between SARS-CoV-2 and exposure risks in health care workers and university employees - a cross-sectional study.", "authors": [{"family": "Nygren", "given": "David", "initials": "D"}, {"family": "Nor\u00e9n", "given": "Jonas", "initials": "J"}, {"family": "De Marinis", "given": "Yang", "initials": "Y"}, {"family": "Holmberg", "given": "Anna", "initials": "A"}, {"family": "Fraenkel", "given": "Carl-Johan", "initials": "C"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-03-09", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": null, "issue": null, "pages": "1-9"}, "abstract": "In health care workers SARS-CoV-2 has been shown to be an occupational health risk, often associated with transmission between health care workers. Yet, insufficient information on transmission dynamics has been presented to elucidate the precise risk factors for contracting SARS-CoV-2 in this group.\r\n\r\nIn this cross-sectional study, we investigated association between questionnaire answers on potential exposure situations and SARS-CoV-2-positivity. Health care workers with and without COVID-19-patient contact at nine units at Sk\u00e5ne University Hospitals in Malm\u00f6 and Lund, Sweden and university employees from Lund University, Sweden were enrolled. To limit impact of health care worker to health care worker transmission, units with known outbreaks were excluded. A SARS-CoV-2-positive case was defined by a previous positive PCR or anti-SARS-CoV-2 IgG in the ZetaGene COVID-19 Antibody Test.\r\n\r\nSARS-CoV-2-positivity was detected in 11/51 (22%) health care workers in COVID-19-units, 10/220 (5%) in non-COVID-19-units and 11/192 (6%) University employees ( p = .001, Fischer's exact). In health care workers, SARS-CoV-2-positivity was associated with work in a designated COVID-19-unit (OR 5.7 (95CI 2.1-16)) and caring for COVID-19-patients during the majority of shifts (OR 5.4 (95CI 2.0-15)). In all participants, SARS-CoV-2-positivity was associated with a confirmed COVID-19 case (OR 10 (95CI 2.0-45)) in the household.\r\n\r\nOur study confirmed previous findings of elevated risk of acquiring SARS-CoV-2 in health care workers in COVID-19-units, despite exclusion of units with known outbreaks. Interestingly, health care workers in non-COVID-19-units had similar risk as University employees. Further measures to improve the safety of health care workers might be needed.KEY POINTSPrevious findings of elevated risk of contracting SARS-CoV-2 in health care workers with COVID-19 patient contact was confirmed, despite exclusion of wards with known SARS-CoV-2 outbreaks. Further measures to improve the safety of health care workers might be needed.", "doi": "10.1080/23744235.2021.1892819", "pmid": "33689558", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-12T06:06:56.943Z", "modified": "2021-06-18T14:49:02.100Z"}, {"entity": "publication", "iuid": "df4389825bde4d01ad2e227a293a4a1b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/df4389825bde4d01ad2e227a293a4a1b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/df4389825bde4d01ad2e227a293a4a1b"}}, "title": "Assessing relative COVID-19 mortality: a Swiss population-based study.", "authors": [{"family": "Hothorn", "given": "Torsten", "initials": "T"}, {"family": "Bopp", "given": "Matthias", "initials": "M"}, {"family": "G\u00fcnthard", "given": "Huldrych", "initials": "H"}, {"family": "Keiser", "given": "Olivia", "initials": "O"}, {"family": "Roelens", "given": "Maroussia", "initials": "M"}, {"family": "Weibull", "given": "Caroline E", "initials": "CE"}, {"family": "Crowther", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2021-03-08", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "3", "pages": "e042387", "issn-l": "2044-6055"}, "abstract": "Severity of the COVID-19 has been previously reported in terms of absolute mortality in SARS-CoV-2 positive cohorts. An assessment of mortality relative to mortality in the general population is presented.\n\nRetrospective population-based study.\n\nIndividual information on symptomatic confirmed SARS-CoV-2 patients and subsequent deaths from any cause were compared with the all-cause mortality in the Swiss population of 2018. Starting 23 February 2020, mortality in COVID-19 patients was monitored for 80 days and compared with the population mortality observed in the same time of year starting 23 February 2018.\n\n5 102 300 inhabitants of Switzerland aged 35-95 without COVID-19 (general population in spring 2018) and 20 769 persons tested positively for COVID-19 during the first wave in spring 2020.\n\nSex-specific and age-specific mortality rates were estimated using Cox proportional hazards models. Absolute probabilities of death were predicted and risk was assessed in terms of relative mortality by taking the ratio between the sex-specific and age-specific absolute mortality in COVID-19 patients and the corresponding mortality in the 2018 general population.\n\nAbsolute mortalities increased with age and were higher for males compared with females, both in the general population and in positively tested persons. A confirmed SARS-CoV-2 infection substantially increased the probability of death across all patient groups at least eightfold. The highest relative mortality risks were observed among males and younger patients. Male COVID-19 patients exceeded the population hazard for males (HR 1.21, 95% CI 1.02 to 1.44). An additional year of age increased the population hazard in COVID-19 patients only marginally (HR 1.00, 95% CI 1.00 to 1.01).\n\nHealthcare professionals, decision-makers and societies are provided with an additional population-adjusted assessment of COVID-19 mortality risk. In combination with absolute measures of risk, the relative risks presented here help to develop a more comprehensive understanding of the actual impact of COVID-19.", "doi": "10.1136/bmjopen-2020-042387", "pmid": "34006026", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-042387"}, {"db": "URL", "key": "https://gitlab.switch.ch/torsten.hothorn/relative_covid-19_mortality", "description": "Data, R and Stata code"}], "notes": [], "created": "2021-05-20T14:50:19.838Z", "modified": "2021-11-19T11:39:40.055Z"}, {"entity": "publication", "iuid": "abdd36ff54f448bb8c50ab2769484a66", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abdd36ff54f448bb8c50ab2769484a66.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abdd36ff54f448bb8c50ab2769484a66"}}, "title": "Digital health and COVID-19: challenges of use and implementation in sub-Saharan Africa.", "authors": [{"family": "Mogessie", "given": "Yidnekachew Girma", "initials": "YG"}, {"family": "Ntacyabukura", "given": "Blaise", "initials": "B"}, {"family": "Mengesha", "given": "Dawit Tesfagiorgis", "initials": "DT"}, {"family": "Musa", "given": "Mohamed Babiker", "initials": "MB"}, {"family": "Wangari", "given": "Marie-Claire", "initials": "MC"}, {"family": "Claude", "given": "Nsabimana", "initials": "N"}, {"family": "Buntongyi", "given": "Nit", "initials": "N"}, {"family": "Lucero-Prisno", "given": "Don Eliseo", "initials": "DE"}], "type": "journal article", "published": "2021-03-07", "journal": {"title": "Pan Afr Med J", "issn": "1937-8688", "volume": "38", "issue": null, "pages": "240", "issn-l": null}, "abstract": "COVID-19 is a global health emergency that exposed the gaps in health systems globally, especially in sub-Saharan Africa home to many fragile healthcare systems and a region beset with a large burden of disease. Various mitigation strategies have been put in place to stop the spread of COVID-19 and management of patients in sub-Saharan Africa. However, much still need to be done. Digital health provides the promise for the continent to bridge the gap in decreasing the negative impact of COVID-19 and effectively mitigate the pandemic. This commentary argues how countries in sub-Saharan Africa need to embrace the use of digital health in public health interventions to vigorously mitigate the COVID-19 pandemic and to contribute towards attaining universal health coverage (UHC).", "doi": "10.11604/pamj.2021.38.240.27948", "pmid": "34046143", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PAMJ-38-240"}, {"db": "pmc", "key": "PMC8140728"}], "notes": [], "created": "2021-05-29T15:23:16.329Z", "modified": "2021-05-29T16:28:47.779Z"}, {"entity": "publication", "iuid": "9e8e161c43634d88b5d5a60fdaa4cbd5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9e8e161c43634d88b5d5a60fdaa4cbd5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9e8e161c43634d88b5d5a60fdaa4cbd5"}}, "title": "Understanding COVID-19 through adverse outcome pathways - 2nd CIAO AOP Design Workshop.", "authors": [{"family": "Wittwehr", "given": "Clemens", "initials": "C"}, {"family": "Amorim", "given": "Maria Jo\u00e3o", "initials": "MJ"}, {"family": "Clerbaux", "given": "Laure-Alix", "initials": "LA"}, {"family": "Krebs", "given": "Catharine", "initials": "C"}, {"family": "Landesmann", "given": "Brigitte", "initials": "B"}, {"family": "Macmillan", "given": "Donna", "initials": "D"}, {"family": "Nymark", "given": "Penny", "initials": "P"}, {"family": "Ram", "given": "Rebecca", "initials": "R"}, {"family": "Garcia-Reyero", "given": "Nat\u00e0lia", "initials": "N"}, {"family": "Sachana", "given": "Magdalini", "initials": "M"}, {"family": "Sullivan", "given": "Kristie", "initials": "K"}, {"family": "Sund", "given": "Jukka", "initials": "J"}, {"family": "Willett", "given": "Catharine", "initials": "C"}], "type": "editorial", "published": "2021-03-05", "journal": {"title": "ALTEX", "issn": "1868-596X", "volume": null, "issue": null, "issn-l": null}, "abstract": "The CIAO project (Modelling the Pathogenesis of COVID\u201119 using the Adverse Outcome Pathway framework) aims at a holistic assembly of knowledge to deliver a truly transdisciplinary description of the entire COVID\u201119 physiopathology starting with the initial contact with the SARS\u2011CoV\u201119 virus and ending with one or several adverse outcomes, e.g., respiratory failure. On 27\u201128 January 2021, a group of 50+ scientists from numerous organizations around the world met in the 2nd CIAO AOP Design Workshop to discuss the depiction of the COVID\u201119 disease process as a series of key events (KEs) in a network of AOPs. During the workshop, 74 such KEs forming 13 AOPs were identified, covering COVID\u201119 manifestations that affect the respiratory, neurological, liver, cardiovascular, kidney and gastrointestinal systems. Modulating factors influencing the course and severity of the disease were also addressed, as was a possible extension of the investigations beyond purely biological phenomena. The workshop ended with the creation of seven working groups, which will further elaborate on the AOPs to be presented and discussed in the 3rd CIAO workshop on 28-29 April 2021.", "doi": "10.14573/altex.2102221", "pmid": "33677612", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-03-09T06:27:27.194Z", "modified": "2021-03-09T06:28:05.358Z"}, {"entity": "publication", "iuid": "ef735d339af4451b8855e6175b157d6b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef735d339af4451b8855e6175b157d6b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef735d339af4451b8855e6175b157d6b"}}, "title": "The emergence and ongoing convergent evolution of the N501Y lineages coincides with a major global shift in the SARS-CoV-2 selective landscape", "authors": [{"family": "Martin", "given": "Darren P", "initials": "DP"}, {"family": "Weaver", "given": "Steven", "initials": "S"}, {"family": "Tegally", "given": "Houryiah", "initials": "H"}, {"family": "San", "given": "Emmanuel James", "initials": "EJ"}, {"family": "Shank", "given": "Stephen D", "initials": "SD"}, {"family": "Wilkinson", "given": "Eduan", "initials": "E"}, {"family": "Giandhari", "given": "Jennifer", "initials": "J"}, {"family": "Naidoo", "given": "Sureshnee", "initials": "S"}, {"family": "Pillay", "given": "Yeshnee", "initials": "Y"}, {"family": "Singh", "given": "Lavanya", "initials": "L"}, {"family": "Lessells", "given": "Richard J", "initials": "RJ"}, {"family": "Gupta", "given": "Ravindra K", "initials": "RK"}, {"family": "Wertheim", "given": "Joel O", "initials": "JO"}, {"family": "Nekturenko", "given": "Anton", "initials": "A"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Harkins", "given": "Gordon W", "initials": "GW"}, {"family": "Lemey", "given": "Philippe", "initials": "P"}, {"family": "MacLean", "given": "Oscar A", "initials": "OA"}, {"family": "Robertson", "given": "David L", "initials": "DL"}, {"family": "de Oliveira", "given": "Tulio", "initials": "T"}, {"family": "Pond", "given": "Sergei L Kosakovsky", "initials": "SLK"}, {"family": "None", "given": "", "initials": ""}, {"family": "None", "given": "", "initials": ""}], "type": "posted-content", "published": "2021-03-05", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "6", "doi": "10.1101/2021.02.23.21252268", "pmid": null, "labels": {"Funder: H2020": null, "Category: Genomics & transcriptomics": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-06-10T03:49:19.420Z", "modified": "2021-06-18T09:11:11.931Z"}, {"entity": "publication", "iuid": "9e297cf816a3407886213128451b438e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9e297cf816a3407886213128451b438e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9e297cf816a3407886213128451b438e"}}, "title": "Point-of-care bulk testing for SARS-CoV-2 by combining hybridization capture with improved colorimetric LAMP.", "authors": [{"family": "Bokelmann", "given": "Lukas", "initials": "L"}, {"family": "Nickel", "given": "Olaf", "initials": "O"}, {"family": "Maricic", "given": "Tomislav", "initials": "T"}, {"family": "P\u00e4\u00e4bo", "given": "Svante", "initials": "S"}, {"family": "Meyer", "given": "Matthias", "initials": "M"}, {"family": "Borte", "given": "Stephan", "initials": "S"}, {"family": "Riesenberg", "given": "Stephan", "initials": "S"}], "type": "journal article", "published": "2021-03-05", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "1467", "issn-l": "2041-1723"}, "abstract": "Efforts to contain the spread of SARS-CoV-2 have spurred the need for reliable, rapid, and cost-effective diagnostic methods which can be applied to large numbers of people. However, current standard protocols for the detection of viral nucleic acids while sensitive, require a high level of automation and sophisticated laboratory equipment to achieve throughputs that allow whole communities to be tested on a regular basis. Here we present Cap-iLAMP (capture and improved loop-mediated isothermal amplification) which combines a hybridization capture-based RNA extraction of gargle lavage samples with an improved colorimetric RT-LAMP assay and smartphone-based color scoring. Cap-iLAMP is compatible with point-of-care testing and enables the detection of SARS-CoV-2 positive samples in less than one hour. In contrast to direct addition of the sample to improved LAMP (iLAMP), Cap-iLAMP prevents false positives and allows single positive samples to be detected in pools of 25 negative samples, reducing the reagent cost per test to ~1 Euro per individual.", "doi": "10.1038/s41467-021-21627-0", "pmid": "33674580", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-21627-0"}], "notes": [], "created": "2021-03-08T10:52:35.942Z", "modified": "2021-03-08T10:57:30.916Z"}, {"entity": "publication", "iuid": "78f0928173d44035925dab2beb610117", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/78f0928173d44035925dab2beb610117.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/78f0928173d44035925dab2beb610117"}}, "title": "No findings of SARS-CoV-2 in conjunctival swabs from patients at an emergency outpatient ophthalmological healthcare facility in a Swedish county hospital: a cross-sectional study.", "authors": [{"family": "Granstam", "given": "Elisabet", "initials": "E"}, {"family": "Krifors", "given": "Anders", "initials": "A"}, {"family": "Freyhult", "given": "Elisabeth", "initials": "E"}, {"family": "\u00c5kerblom", "given": "Hanna", "initials": "H"}], "type": "journal article", "published": "2021-03-05", "journal": {"title": "BMJ Open Ophthalmol", "issn": "2397-3269", "volume": "6", "issue": "1", "pages": "e000616", "issn-l": null}, "abstract": "COVID-19 is caused by SARS-CoV-2. Virus has been found in conjunctiva of hospitalised patients with COVID-19. Conjunctivitis has also been reported as a presenting symptom of disease.\n\nThe aims of the study were to investigate the prevalence of SARS-CoV-2 in the conjunctiva and throat among patients presenting at the emergency outpatient ophthalmological healthcare facility at a county hospital along with investigating the seroprevalence of SARS-CoV-2 among staff at the department.\n\nSwabs from conjunctiva and throat of patients were analysed with real-time reverse transcriptase PCR (RT-PCR) for SARS-CoV-2. Blood samples for serological analysis were obtained from staff. A questionnaire was used to investigate symptoms associated with COVID-19 during the last 3 months as well as symptoms for which the patients were seeking ophthalmological healthcare.\n\nIn total, 68 patients and 70 individuals from the staff were included in the study. Conjunctivitis was observed in 7% of patients. One patient, presenting with reduced visual acuity due to preretinal haemorrhage in the macula, was positive for SARS-CoV-2 in throat swab. Contact tracing was negative. All other RT-PCR tests were negative. Seropositivity for SARS-CoV-2 was found in 4% of staff.\n\nOur study demonstrated low prevalence of SARS-CoV-2 among patients as well as low seroprevalence of SARS-CoV-2 IgG-antibodies among staff at the ophthalmological ward. The risk for contracting COVID-19 at the department was small. Follow-up investigation is planned.", "doi": "10.1136/bmjophth-2020-000616", "pmid": "34041362", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjophth-2020-000616"}, {"db": "pmc", "key": "PMC7938470"}], "notes": [], "created": "2021-05-29T15:28:44.179Z", "modified": "2021-05-29T15:28:44.201Z"}, {"entity": "publication", "iuid": "3cee578a4158419fa545d7efe3fd8b58", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3cee578a4158419fa545d7efe3fd8b58.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3cee578a4158419fa545d7efe3fd8b58"}}, "title": "Burden of Disease Methods: A Guide to Calculate COVID-19 Disability-Adjusted Life Years.", "authors": [{"family": "Wyper", "given": "Grant M A", "initials": "GMA"}, {"family": "Assun\u00e7\u00e3o", "given": "Ricardo M A", "initials": "RMA"}, {"family": "Colzani", "given": "Edoardo", "initials": "E"}, {"family": "Grant", "given": "Ian", "initials": "I"}, {"family": "Haagsma", "given": "Juanita A", "initials": "JA"}, {"family": "Lagerweij", "given": "Giske", "initials": "G"}, {"family": "Von der Lippe", "given": "Elena", "initials": "E"}, {"family": "McDonald", "given": "Scott A", "initials": "SA"}, {"family": "Pires", "given": "Sara M", "initials": "SM"}, {"family": "Porst", "given": "Michael", "initials": "M"}, {"family": "Speybroeck", "given": "Niko", "initials": "N"}, {"family": "Devleesschauwer", "given": "Brecht", "initials": "B"}], "type": "journal article", "published": "2021-03-05", "journal": {"title": "Int J Public Health", "issn": "1661-8564", "volume": "66", "pages": "619011", "issn-l": null}, "abstract": null, "doi": "10.3389/ijph.2021.619011", "pmid": "34744580", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "619011"}, {"db": "pmc", "key": "PMC8565264"}], "notes": [], "created": "2021-11-26T15:35:22.656Z", "modified": "2021-11-26T15:35:22.669Z"}, {"entity": "publication", "iuid": "a044efb1677249b29be6bbb0a662f825", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a044efb1677249b29be6bbb0a662f825.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a044efb1677249b29be6bbb0a662f825"}}, "title": "A chronicle of SARS-CoV-2: Seasonality, environmental fate, transport, inactivation, and antiviral drug resistance.", "authors": [{"family": "Kumar", "given": "Manish", "initials": "M"}, {"family": "Mazumder", "given": "Payal", "initials": "P"}, {"family": "Mohapatra", "given": "Sanjeeb", "initials": "S"}, {"family": "Kumar Thakur", "given": "Alok", "initials": "A"}, {"family": "Dhangar", "given": "Kiran", "initials": "K"}, {"family": "Taki", "given": "Kaling", "initials": "K"}, {"family": "Mukherjee", "given": "Santanu", "initials": "S"}, {"family": "Kumar Patel", "given": "Arbind", "initials": "A"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Mohapatra", "given": "Pranab", "initials": "P"}, {"family": "Rinklebe", "given": "J\u00f6rg", "initials": "J"}, {"family": "Kitajima", "given": "Masaaki", "initials": "M"}, {"family": "Hai", "given": "Faisal I", "initials": "FI"}, {"family": "Khursheed", "given": "Anwar", "initials": "A"}, {"family": "Furumai", "given": "Hiroaki", "initials": "H"}, {"family": "Sonne", "given": "Christian", "initials": "C"}, {"family": "Kuroda", "given": "Keisuke", "initials": "K"}], "type": "journal article", "published": "2021-03-05", "journal": {"title": "J Hazard Mater", "issn": "1873-3336", "volume": "405", "issue": null, "pages": "124043", "issn-l": null}, "abstract": "In this review, we present the environmental perspectives of the viruses and antiviral drugs related to SARS-CoV-2. The present review paper discusses occurrence, fate, transport, susceptibility, and inactivation mechanisms of viruses in the environment as well as environmental occurrence and fate of antiviral drugs, and prospects (prevalence and occurrence) of antiviral drug resistance (both antiviral drug resistant viruses and antiviral resistance in the human). During winter, the number of viral disease cases and environmental occurrence of antiviral drug surge due to various biotic and abiotic factors such as transmission pathways, human behaviour, susceptibility, and immunity as well as cold climatic conditions. Adsorption and persistence critically determine the fate and transport of viruses in the environment. Inactivation and disinfection of virus include UV, alcohol, and other chemical-base methods but the susceptibility of virus against these methods varies. Wastewater treatment plants (WWTPs) are major reserviors of antiviral drugs and their metabolites and transformation products. Ecotoxicity of antiviral drug residues against aquatic organisms have been reported, however more threatening is the development of antiviral resistance, both in humans and in wild animal reservoirs. In particular, emergence of antiviral drug-resistant viruses via exposure of wild animals to high loads of antiviral residues during the current pandemic needs further evaluation.", "doi": "10.1016/j.jhazmat.2020.124043", "pmid": "33268203", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0304-3894(20)32033-1"}, {"db": "pmc", "key": "PMC7536132"}], "notes": [], "created": "2021-02-10T18:52:29.712Z", "modified": "2021-02-10T18:53:14.080Z"}, {"entity": "publication", "iuid": "2df5739354b6453abf381a53d3a6c530", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2df5739354b6453abf381a53d3a6c530.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2df5739354b6453abf381a53d3a6c530"}}, "title": "OmicLoupe: facilitating biological discovery by interactive exploration of multiple omic datasets and statistical comparisons.", "authors": [{"family": "Willforss", "given": "Jakob", "initials": "J"}, {"family": "Siino", "given": "Valentina", "initials": "V"}, {"family": "Levander", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2021-03-04", "journal": {"title": "BMC Bioinformatics", "issn": "1471-2105", "volume": "22", "issue": "1", "pages": "107", "issn-l": null}, "abstract": "Visual exploration of gene product behavior across multiple omic datasets can pinpoint technical limitations in data and reveal biological trends. Still, such exploration is challenging as there is a need for visualizations that are tailored for the purpose.\n\nThe OmicLoupe software was developed to facilitate visual data exploration and provides more than 15 interactive cross-dataset visualizations for omics data. It expands visualizations to multiple datasets for quality control, statistical comparisons and overlap and correlation analyses, while allowing for rapid inspection and downloading of selected features. The usage of OmicLoupe is demonstrated in three different studies, where it allowed for detection of both technical data limitations and biological trends across different omic layers. An example is an analysis of SARS-CoV-2 infection based on two previously published studies, where OmicLoupe facilitated the identification of gene products with consistent expression changes across datasets at both the transcript and protein levels.\n\nOmicLoupe provides fast exploration of omics data with tailored visualizations for comparisons within and across data layers. The interactive visualizations are highly informative and are expected to be useful in various analyses of both newly generated and previously published data. OmicLoupe is available at quantitativeproteomics.org/omicloupe.", "doi": "10.1186/s12859-021-04043-5", "pmid": "33663372", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12859-021-04043-5"}], "notes": [], "created": "2021-03-06T10:15:06.148Z", "modified": "2021-03-06T10:15:06.170Z"}, {"entity": "publication", "iuid": "e52c4079071d410b99cb020629c9705c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e52c4079071d410b99cb020629c9705c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e52c4079071d410b99cb020629c9705c"}}, "title": "Antibodies to SARS-CoV-2 and risk of past or future sick leave.", "authors": [{"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Elfstr\u00f6m", "given": "K Miriam", "initials": "KM"}, {"family": "Blomqvist", "given": "Jonas", "initials": "J"}, {"family": "Eklund", "given": "Carina", "initials": "C"}, {"family": "Lagheden", "given": "Camilla", "initials": "C"}, {"family": "Nordqvist-Kleppe", "given": "Sara", "initials": "S"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Olofsson", "given": "Jennie", "initials": "J"}, {"family": "Andersson", "given": "Eni", "initials": "E"}, {"family": "Jernbom Falk", "given": "August", "initials": "A"}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S"}, {"family": "Hultin", "given": "Emilie", "initials": "E"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Mattsson", "given": "Johan", "initials": "J"}, {"family": "M\u00fchr", "given": "Laila Sara Arroyo", "initials": "LSA"}, {"family": "Conneryd Lundgren", "given": "Kalle", "initials": "K"}], "type": "journal article", "published": "2021-03-04", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "5160"}, "abstract": "The extent that antibodies to SARS-CoV-2 may protect against future virus-associated disease is unknown. We invited all employees (n = 15,300) at work at the Karolinska University Hospital, Stockholm, Sweden to participate in a study examining SARS-Cov-2 antibodies in relation to registered sick leave. For consenting 12,928 healthy hospital employees antibodies to SARS-CoV-2 could be determined and compared to participant sick leave records. Subjects with viral serum antibodies were not at excess risk for future sick leave (adjusted odds ratio (OR) controlling for age and sex: 0.85 [95% confidence interval (CI) (0.85 (0.43-1.68)]. By contrast, subjects with antibodies had an excess risk for sick leave in the weeks prior to testing [adjusted OR in multivariate analysis: 3.34 (2.98-3.74)]. Thus, presence of viral antibodies marks past disease and protection against excess risk of future disease. Knowledge of whether exposed subjects have had disease in the past or are at risk for future disease is essential for planning of control measures.Trial registration: First registered on 02/06/20, ClinicalTrials.gov NCT04411576.", "doi": "10.1038/s41598-021-84356-w", "pmid": "33664279", "labels": {"Category: Health": null, "Category: Proteins": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Research Area: High-throughput and high-content serology": null}, "xrefs": [{"db": "pmc", "key": "PMC7933367"}, {"db": "pii", "key": "10.1038/s41598-021-84356-w"}, {"db": "ClinicalTrials.gov", "key": "NCT04411576"}], "notes": [], "created": "2021-03-06T10:13:45.982Z", "modified": "2023-06-19T14:23:55.553Z"}, {"entity": "publication", "iuid": "66c7514e2642441da18b49f672fd2839", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66c7514e2642441da18b49f672fd2839.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66c7514e2642441da18b49f672fd2839"}}, "title": "Seroprevalence of coronavirus disease 2019 (COVID-19) among health care workers from three pandemic hospitals of Turkey.", "authors": [{"family": "Alkurt", "given": "Gizem", "initials": "G"}, {"family": "Murt", "given": "Ahmet", "initials": "A"}, {"family": "Aydin", "given": "Zeki", "initials": "Z"}, {"family": "Tatli", "given": "Ozge", "initials": "O"}, {"family": "Agaoglu", "given": "Nihat Bugra", "initials": "NB"}, {"family": "Irvem", "given": "Arzu", "initials": "A"}, {"family": "Aydin", "given": "Mehtap", "initials": "M"}, {"family": "Karaali", "given": "Ridvan", "initials": "R"}, {"family": "Gunes", "given": "Mustafa", "initials": "M"}, {"family": "Yesilyurt", "given": "Batuhan", "initials": "B"}, {"family": "Turkez", "given": "Hasan", "initials": "H"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A"}, {"family": "Doganay", "given": "Mehmet", "initials": "M"}, {"family": "Basinoglu", "given": "Filiz", "initials": "F"}, {"family": "Seyahi", "given": "Nurhan", "initials": "N"}, {"family": "Dinler Doganay", "given": "Gizem", "initials": "G"}, {"family": "Doganay", "given": "Hamdi Levent", "initials": "HL"}], "type": "journal article", "published": "2021-03-03", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "3", "pages": "e0247865", "issn-l": "1932-6203"}, "abstract": "COVID-19 is a global threat with an increasing number of infections. Research on IgG seroprevalence among health care workers (HCWs) is needed to re-evaluate health policies. This study was performed in three pandemic hospitals in Istanbul and Kocaeli. Different clusters of HCWs were screened for SARS-CoV-2 infection. Seropositivity rate among participants was evaluated by chemiluminescent microparticle immunoassay. We recruited 813 non-infected and 119 PCR-confirmed infected HCWs. Of the previously undiagnosed HCWs, 22 (2.7%) were seropositive. Seropositivity rates were highest for cleaning staff (6%), physicians (4%), nurses (2.2%) and radiology technicians (1%). Non-pandemic clinic (6.4%) and ICU (4.3%) had the highest prevalence. HCWs in \"high risk\" group had similar seropositivity rate with \"no risk\" group (2.9 vs 3.5 p = 0.7). These findings might lead to the re-evaluation of infection control and transmission dynamics in hospitals.", "doi": "10.1371/journal.pone.0247865", "pmid": "33657142", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-35740"}], "notes": [], "created": "2021-03-04T14:59:29.060Z", "modified": "2021-03-04T14:59:44.375Z"}, {"entity": "publication", "iuid": "bd36b3d1e82d4558a7b9f1fdd6cd21c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bd36b3d1e82d4558a7b9f1fdd6cd21c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bd36b3d1e82d4558a7b9f1fdd6cd21c0"}}, "title": "In education we trust: on handling the COVID-19 Pandemic in the Swedish welfare state.", "authors": [{"family": "Lindblad", "given": "Sverker", "initials": "S", "orcid": "0000-0003-3481-3686", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/643e57912c7b487abde1d0bb0cb62bcd.json"}}, {"family": "Lindqvist", "given": "Anders", "initials": "A"}, {"family": "Runesdotter", "given": "Caroline", "initials": "C"}, {"family": "W\u00e4rvik", "given": "Gun-Britt", "initials": "GB"}], "type": "journal article", "published": "2021-03-03", "journal": {"title": "Z Erziehungswiss", "issn": "1434-663X", "volume": "24", "issue": "2", "pages": "503-519", "issn-l": null}, "abstract": "Keeping schools open was an active strategy in Sweden to meet the threats of the COVID-19 pandemic. In this article we analyze how a collection of welfare state agents with different tasks, resources and interests in interaction formed an assemblage in their responses to the pandemic and how education thereby became part of a strategy to keep the society going. The inquiries concern what this tells us about education as framed and constrained as a part of society. Our observations are based on statements presented by the government and public agencies, mass media and websites. We identified an assemblage of interwoven agents such as institutions, laws, regulations and recommendations, pandemic manuals, statistics and media. All these were brought together by actions and ideas to handle a pandemic when there were no preventive vaccines. The overarching principle was to educate the population to competent actions in dealing with the pandemic. To keep schools open was part of that principle combined with caretaking ambitions. This assemblage looked like a centralistic machine but it was not; risks were pushed back to local authorities and schools. In conclusion, we note that education is vital in the overarching strategy to deal with the pandemic in Sweden in terms of trust in people and governmentality.", "doi": "10.1007/s11618-021-01001-y", "pmid": "33686342", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7927774"}, {"db": "pii", "key": "1001"}], "notes": [], "created": "2021-03-09T15:38:30.715Z", "modified": "2023-06-19T15:03:30.315Z"}, {"entity": "publication", "iuid": "a0855feda5bb4681ad704142bd8b900e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a0855feda5bb4681ad704142bd8b900e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a0855feda5bb4681ad704142bd8b900e"}}, "title": "Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity.", "authors": [{"family": "Hoffmann", "given": "Markus", "initials": "M"}, {"family": "Hofmann-Winkler", "given": "Heike", "initials": "H"}, {"family": "Smith", "given": "Joan C", "initials": "JC"}, {"family": "Kr\u00fcger", "given": "Nadine", "initials": "N"}, {"family": "Arora", "given": "Prerna", "initials": "P"}, {"family": "S\u00f8rensen", "given": "Lambert K", "initials": "LK"}, {"family": "S\u00f8gaard", "given": "Ole S", "initials": "OS"}, {"family": "Hasselstr\u00f8m", "given": "J\u00f8rgen Bo", "initials": "JB"}, {"family": "Winkler", "given": "Michael", "initials": "M"}, {"family": "Hempel", "given": "Tim", "initials": "T"}, {"family": "Raich", "given": "Llu\u00eds", "initials": "L"}, {"family": "Olsson", "given": "Simon", "initials": "S"}, {"family": "Danov", "given": "Olga", "initials": "O"}, {"family": "Jonigk", "given": "Danny", "initials": "D"}, {"family": "Yamazoe", "given": "Takashi", "initials": "T"}, {"family": "Yamatsuta", "given": "Katsura", "initials": "K"}, {"family": "Mizuno", "given": "Hirotaka", "initials": "H"}, {"family": "Ludwig", "given": "Stephan", "initials": "S"}, {"family": "No\u00e9", "given": "Frank", "initials": "F"}, {"family": "Kjolby", "given": "Mads", "initials": "M"}, {"family": "Braun", "given": "Armin", "initials": "A"}, {"family": "Sheltzer", "given": "Jason M", "initials": "JM"}, {"family": "P\u00f6hlmann", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2021-03-03", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "volume": null, "issue": null, "pages": "103255", "issn-l": null}, "abstract": "Antivirals are needed to combat the COVID-19 pandemic, which is caused by SARS-CoV-2. The clinically-proven protease inhibitor Camostat mesylate inhibits SARS-CoV-2 infection by blocking the virus-activating host cell protease TMPRSS2. However, antiviral activity of Camostat mesylate metabolites and potential viral resistance have not been analyzed. Moreover, antiviral activity of Camostat mesylate in human lung tissue remains to be demonstrated.\n\nWe used recombinant TMPRSS2, reporter particles bearing the spike protein of SARS-CoV-2 or authentic SARS-CoV-2 to assess inhibition of TMPRSS2 and viral entry, respectively, by Camostat mesylate and its metabolite GBPA.\n\nWe show that several TMPRSS2-related proteases activate SARS-CoV-2 and that two, TMPRSS11D and TMPRSS13, are robustly expressed in the upper respiratory tract. However, entry mediated by these proteases was blocked by Camostat mesylate. The Camostat metabolite GBPA inhibited recombinant TMPRSS2 with reduced efficiency as compared to Camostat mesylate. In contrast, both inhibitors exhibited similar antiviral activity and this correlated with the rapid conversion of Camostat mesylate into GBPA in the presence of serum. Finally, Camostat mesylate and GBPA blocked SARS-CoV-2 spread in human lung tissue ex vivo and the related protease inhibitor Nafamostat mesylate exerted augmented antiviral activity.\n\nOur results suggest that SARS-CoV-2 can use TMPRSS2 and closely related proteases for spread in the upper respiratory tract and that spread in the human lung can be blocked by Camostat mesylate and its metabolite GBPA.\n\nNIH, Damon Runyon Foundation, ACS, NYCT, DFG, EU, Berlin Mathematics center MATH+, BMBF, Lower Saxony, Lundbeck Foundation, Novo Nordisk Foundation.", "doi": "10.1016/j.ebiom.2021.103255", "pmid": "33676899", "labels": {"Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2352-3964(21)00048-7"}], "notes": [], "created": "2021-03-09T06:29:35.329Z", "modified": "2021-03-09T06:29:35.339Z"}, {"entity": "publication", "iuid": "ccc828de9ffc4d4faf4cbfa6038f8205", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ccc828de9ffc4d4faf4cbfa6038f8205.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ccc828de9ffc4d4faf4cbfa6038f8205"}}, "title": "The effects of school closures on SARS-CoV-2 among parents and teachers.", "authors": [{"family": "Vlachos", "given": "Jonas", "initials": "J"}, {"family": "Herteg\u00e5rd", "given": "Edvin", "initials": "E"}, {"family": "B Svaleryd", "given": "Helena", "initials": "H"}], "type": "journal article", "published": "2021-03-02", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "issn-l": "0027-8424", "volume": "118", "issue": "9", "pages": null}, "abstract": "To reduce the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), most countries closed schools, despite uncertainty if school closures are an effective containment measure. At the onset of the pandemic, Swedish upper-secondary schools moved to online instruction, while lower-secondary schools remained open. This allows for a comparison of parents and teachers differently exposed to open and closed schools, but otherwise facing similar conditions. Leveraging rich Swedish register data, we connect all students and teachers in Sweden to their families and study the impact of moving to online instruction on the incidence of SARS-CoV-2 and COVID-19. We find that, among parents, exposure to open rather than closed schools resulted in a small increase in PCR-confirmed infections (odds ratio [OR] 1.17; 95% CI [CI95] 1.03 to 1.32). Among lower-secondary teachers, the infection rate doubled relative to upper-secondary teachers (OR 2.01; CI95 1.52 to 2.67). This spilled over to the partners of lower-secondary teachers, who had a higher infection rate than their upper-secondary counterparts (OR 1.29; CI95 1.00 to 1.67). When analyzing COVID-19 diagnoses from healthcare visits and the incidence of severe health outcomes, results are similar for teachers, but weaker for parents and teachers' partners. The results for parents indicate that keeping lower-secondary schools open had minor consequences for the overall transmission of SARS-CoV-2 in society. The results for teachers suggest that measures to protect teachers could be considered.", "doi": "10.1073/pnas.2020834118", "pmid": "33574041", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "2020834118"}, {"db": "URL", "key": "https://doi.org/10.17605/OSF.IO/4ZEGU", "description": "Analysis code"}, {"db": "NA", "key": "Data available from Statistics Sweden, the Public Health Agency, the National Board of Health and Welfare", "description": null}], "notes": [], "created": "2021-02-15T10:48:23.120Z", "modified": "2022-11-23T09:02:06.517Z"}, {"entity": "publication", "iuid": "6fc0a21da50a4bddbdf07a5a63b48e36", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6fc0a21da50a4bddbdf07a5a63b48e36.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6fc0a21da50a4bddbdf07a5a63b48e36"}}, "title": "Protection induced by a human monoclonal antibody recognizing two different epitopes in a conserved region of streptococcal M proteins", "authors": [{"family": "Bahnan", "given": "Wael", "initials": "W"}, {"family": "Happonen", "given": "Lotta", "initials": "L"}, {"family": "Khakzad", "given": "Hamed", "initials": "H"}, {"family": "Ahnlide", "given": "Vibha Kumra", "initials": "VK"}, {"family": "de Neergaard", "given": "Therese", "initials": "T"}, {"family": "Wrighton", "given": "Sebastian", "initials": "S"}, {"family": "Bratanis", "given": "Eleni", "initials": "E"}, {"family": "Tang", "given": "Di", "initials": "D"}, {"family": "Hellmark", "given": "Thomas", "initials": "T"}, {"family": "Bj\u00f6rck", "given": "Lars", "initials": "L"}, {"family": "Shannon", "given": "Oonagh", "initials": "O"}, {"family": "Malmstr\u00f6m", "given": "Lars", "initials": "L"}, {"family": "Malmstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Nordenfelt", "given": "Pontus", "initials": "P"}], "type": "posted-content", "published": "2021-03-02", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.01.433494", "pmid": null, "labels": {"Category: Biochemistry": null, "Category: Proteins": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-03-22T12:39:21.164Z", "modified": "2021-03-22T13:33:56.820Z"}, {"entity": "publication", "iuid": "cec1e1228ccc42ad9bca389bad602a9e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cec1e1228ccc42ad9bca389bad602a9e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cec1e1228ccc42ad9bca389bad602a9e"}}, "title": "Has COVID-19 Improved Public Awareness on Oral Hygiene?", "authors": [{"family": "SOROOSHIAN", "given": "Shahryar", "initials": "S"}, {"family": "KUMAR", "given": "Senthil", "initials": "S"}], "type": "journal-article", "published": "2021-03-02", "journal": {"title": "ijph", "issn": "2251-6093", "issn-l": null}, "abstract": null, "doi": "10.18502/ijph.v50i3.5626", "pmid": null, "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:06:14.132Z", "modified": "2021-06-28T18:06:14.163Z"}, {"entity": "publication", "iuid": "564a9c99c97f4c13914ec11dd3809290", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/564a9c99c97f4c13914ec11dd3809290.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/564a9c99c97f4c13914ec11dd3809290"}}, "title": "Epidemiology and transmission characteristics of early COVID-19 cases, 20 January-19 March 2020, in Bavaria, Germany.", "authors": [{"family": "B\u00f6hm", "given": "S", "initials": "S", "orcid": "0000-0002-5807-8092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4eb44d818744a98bc5e936918ffd690.json"}}, {"family": "Woudenberg", "given": "T", "initials": "T"}, {"family": "Chen", "given": "D", "initials": "D"}, {"family": "Marosevic", "given": "D V", "initials": "DV"}, {"family": "B\u00f6hmer", "given": "M M", "initials": "MM"}, {"family": "Hansen", "given": "L", "initials": "L"}, {"family": "Wallinga", "given": "J", "initials": "J"}, {"family": "Sing", "given": "A", "initials": "A"}, {"family": "Katz", "given": "K", "initials": "K"}], "type": "journal article", "published": "2021-03-02", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": "149", "issue": null, "pages": "e65", "issn-l": null}, "abstract": "Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) led to a significant disease burden and disruptions in health systems. We describe the epidemiology and transmission characteristics of early coronavirus disease 2019 (COVID-19) cases in Bavaria, Germany. Cases were reverse transcription polymerase chain reaction (RT-PCR)-confirmed SARS-CoV-2 infections, reported from 20 January-19 March 2020. The incubation period was estimated using travel history and date of symptom onset. To estimate the serial interval, we identified pairs of index and secondary cases. By 19 March, 3546 cases were reported. A large proportion was exposed abroad (38%), causing further local transmission. Median incubation period of 256 cases with exposure abroad was 3.8 days (95%CI: 3.5-4.2). For 95% of infected individuals, symptom onset occurred within 10.3 days (95%CI: 9.1-11.8) after exposure. The median serial interval, using 53 pairs, was 3.5 days (95%CI: 3.0-4.2; mean: 3.9, s.d.: 2.2). Travellers returning to Germany had an important influence on the spread of SARS-CoV-2 infections in Bavaria in early 2020. Especially in times of low incidence, public health agencies should identify holiday destinations, and areas with ongoing local transmission, to monitor potential importation of SARS-CoV-2 infections. Travellers returning from areas with ongoing community transmission should be advised to quarantine to prevent re-introductions of COVID-19.", "doi": "10.1017/S0950268821000510", "pmid": "33650470", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7985897"}, {"db": "pii", "key": "S0950268821000510"}], "notes": [], "created": "2021-03-03T17:00:47.834Z", "modified": "2023-06-19T15:24:04.172Z"}, {"entity": "publication", "iuid": "ffff55339bad42d49fd284235c6370e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ffff55339bad42d49fd284235c6370e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ffff55339bad42d49fd284235c6370e8"}}, "title": "A genomic region associated with protection against severe COVID-19 is inherited from Neandertals", "authors": [{"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "P\u00e4\u00e4bo", "given": "Svante", "initials": "S"}], "type": "journal-article", "published": "2021-03-02", "journal": {"title": "Proc Natl Acad Sci USA", "issn": "0027-8424", "issn-l": "0027-8424", "volume": "118", "issue": "9", "pages": "e2026309118"}, "abstract": null, "doi": "10.1073/pnas.2026309118", "pmid": null, "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [], "notes": [], "created": "2021-02-17T15:07:25.648Z", "modified": "2021-02-26T08:45:14.519Z"}, {"entity": "publication", "iuid": "35bd0616989944c68f1bb94cceed8411", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/35bd0616989944c68f1bb94cceed8411.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/35bd0616989944c68f1bb94cceed8411"}}, "title": "Time series analysis and mechanistic modelling of heterogeneity and sero-reversion in antibody responses to mild SARS\u2011CoV-2 infection.", "authors": [{"family": "Manisty", "given": "Charlotte", "initials": "C"}, {"family": "Treibel", "given": "Thomas Alexander", "initials": "TA"}, {"family": "Jensen", "given": "Melanie", "initials": "M"}, {"family": "Semper", "given": "Amanda", "initials": "A"}, {"family": "Joy", "given": "George", "initials": "G"}, {"family": "Gupta", "given": "Rishi K", "initials": "RK"}, {"family": "Cutino-Moguel", "given": "Teresa", "initials": "T"}, {"family": "Andiapen", "given": "Mervyn", "initials": "M"}, {"family": "Jones", "given": "Jessica", "initials": "J"}, {"family": "Taylor", "given": "Stephen", "initials": "S"}, {"family": "Otter", "given": "Ashley", "initials": "A"}, {"family": "Pade", "given": "Corrina", "initials": "C"}, {"family": "Gibbons", "given": "Joseph", "initials": "J"}, {"family": "Lee", "given": "Jason", "initials": "J"}, {"family": "Bacon", "given": "Joanna", "initials": "J"}, {"family": "Thomas", "given": "Steve", "initials": "S"}, {"family": "Moon", "given": "Chris", "initials": "C"}, {"family": "Jones", "given": "Meleri", "initials": "M"}, {"family": "Williams", "given": "Dylan", "initials": "D"}, {"family": "Lambourne", "given": "Jonathan", "initials": "J"}, {"family": "Fontana", "given": "Marianna", "initials": "M"}, {"family": "Altmann", "given": "Daniel M", "initials": "DM"}, {"family": "Boyton", "given": "Rosemary", "initials": "R"}, {"family": "Maini", "given": "Mala", "initials": "M"}, {"family": "McKnight", "given": "Aine", "initials": "A"}, {"family": "Chain", "given": "Benjamin", "initials": "B"}, {"family": "Noursadeghi", "given": "Mahdad", "initials": "M"}, {"family": "Moon", "given": "James C", "initials": "JC"}], "type": "journal article", "published": "2021-03-01", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": "65", "issue": null, "pages": "103259"}, "abstract": "SARS-CoV-2 serology is used to identify prior infection at individual and at population level. Extended longitudinal studies with multi-timepoint sampling to evaluate dynamic changes in antibody levels are required to identify the time horizon in which these applications of serology are valid, and to explore the longevity of protective humoral immunity.\r\n\r\nHealthcare workers were recruited to a prospective cohort study from the first SARS-CoV-2 epidemic peak in London, undergoing weekly symptom screen, viral PCR and blood sampling over 16-21 weeks. Serological analysis (n =12,990) was performed using semi-quantitative Euroimmun IgG to viral spike S1 domain and Roche total antibody to viral nucleocapsid protein (NP) assays. Comparisons were made to pseudovirus neutralizing antibody measurements.\r\n\r\nA total of 157/729 (21.5%) participants developed positive SARS-CoV-2 serology by one or other assay, of whom 31.0% were asymptomatic and there were no deaths. Peak Euroimmun anti-S1 and Roche anti-NP measurements correlated (r = 0.57, p<0.0001) but only anti-S1 measurements correlated with near-contemporary pseudovirus neutralising antibody titres (measured at 16-18 weeks, r = 0.57, p<0.0001). By 21 weeks' follow-up, 31/143 (21.7%) anti-S1 and 6/150 (4.0%) anti-NP measurements reverted to negative. Mathematical modelling revealed faster clearance of anti-S1 compared to anti-NP (median half-life of 2.5 weeks versus 4.0 weeks), earlier transition to lower levels of antibody production (median of 8 versus 13 weeks), and greater reductions in relative antibody production rate after the transition (median of 35% versus 50%).\r\n\r\nMild SARS-CoV-2 infection is associated with heterogeneous serological responses in Euroimmun anti-S1 and Roche anti-NP assays. Anti-S1 responses showed faster rates of clearance, more rapid transition from high to low level production rate and greater reduction in production rate after this transition. In mild infection, anti-S1 serology alone may underestimate incident infections. The mechanisms that underpin faster clearance and lower rates of sustained anti-S1 production may impact on the longevity of humoral immunity.\r\n\r\nCharitable donations via Barts Charity, Wellcome Trust, NIHR.", "doi": "10.1016/j.ebiom.2021.103259", "pmid": "33662833", "labels": {"Category: Proteins": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "S2352-3964(21)00052-9"}, {"db": "pmc", "key": "PMC7920816"}, {"db": "URL", "key": "https://covid-consortium.com/", "description": "Applications for access to the individual participant de-identified data (including data dictionaries) and samples can be made to the access committee"}], "notes": [], "created": "2021-03-06T10:15:49.479Z", "modified": "2021-03-12T10:31:44.422Z"}, {"entity": "publication", "iuid": "a956b3bcb88f402da5231b8f655fa49e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a956b3bcb88f402da5231b8f655fa49e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a956b3bcb88f402da5231b8f655fa49e"}}, "title": "Why people failed to adhere to COVID-19 preventive behaviors? Perspectives from an integrated behavior change model", "authors": [{"family": "Chan", "given": "Derwin K C", "initials": "DKC", "orcid": "0000-0001-8200-0263", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37f65888980c44a4a60077bfb9c2a943.json"}}, {"family": "Zhang", "given": "Chun Qing", "initials": "CQ"}, {"family": "Weman-Josefsson", "given": "Karin", "initials": "K"}], "type": "journal-article", "published": "2021-03-00", "journal": {"title": "Infect Control Hosp Epidemiol", "issn": "0899-823X", "volume": "42", "issue": "3", "pages": "375-376", "issn-l": null}, "abstract": null, "doi": "10.1017/ice.2020.245", "pmid": "32408917", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0899823X20002457"}, {"db": "pmc", "key": "PMC7253766"}], "notes": [], "created": "2020-12-10T08:49:50.394Z", "modified": "2021-12-06T13:14:00.408Z"}, {"entity": "publication", "iuid": "d3240cf5394c47d98e0b3177006fc717", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3240cf5394c47d98e0b3177006fc717.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3240cf5394c47d98e0b3177006fc717"}}, "title": "What do people hospitalised with COVID-19 think about their care? Results of a satisfaction survey during the first wave of COVID-19 in Liverpool.", "authors": [{"family": "Wu", "given": "Meng-San", "initials": "MS"}, {"family": "Watson", "given": "Rebecca", "initials": "R"}, {"family": "Hayat", "given": "Fatima", "initials": "F"}, {"family": "Ratcliffe", "given": "Libuse", "initials": "L"}, {"family": "Beadsworth", "given": "Mike Bj", "initials": "MB"}, {"family": "McKenna", "given": "Mark", "initials": "M"}, {"family": "Corney", "given": "Daniel", "initials": "D"}, {"family": "Plum", "given": "Catherine", "initials": "C"}, {"family": "Macfarlane", "given": "Jamie-Leigh", "initials": "JL"}, {"family": "Matareed", "given": "Maisoon", "initials": "M"}, {"family": "Butt", "given": "Sundas", "initials": "S"}, {"family": "Gupta", "given": "Sandipika", "initials": "S"}, {"family": "Hine", "given": "Paul", "initials": "P"}, {"family": "Defres", "given": "Sylviane", "initials": "S"}, {"family": "Wingfield", "given": "Tom", "initials": "T"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Future Healthc J", "issn": "2514-6645", "volume": "8", "issue": "1", "pages": "e70-e75", "issn-l": null}, "abstract": "Despite huge advances in vaccines, testing and treatments for COVID-19, there is negligible evidence on the perceptions of people hospitalised with COVID-19 about the care they received. To address this, we developed a satisfaction survey for people with COVID-19 admitted to our hospital during the first COVID-19 wave in Liverpool. Of those invited, 98/160 (61%) responded, of whom 94/98 (96%) completed the survey. Respondents rated overall care highly (mean 4.7/5) and 89/94 (95%) reported that they would recommend the hospital to friends and/or family. Most respondents felt safe on the ward (94%), with privacy maintained (93%) and pain well managed (90%). Fewer than two-thirds (63%) of respondents considered themselves adequately consulted regarding medications and side effects. Sleep and food/drink quality were also highlighted as areas for improvement. To overcome the issues raised, we generated a 'COVID-19 practice pointers' poster within an integrated educational bundle on COVID-19 wards. The impact of the bundle on perceptions of people hospitalised with COVID-19 will be evaluated in people hospitalised with COVID-19 in Liverpool in 2021. Whether hospitalised for COVID-19 or other conditions, our survey results are a timely reminder of the importance of involving patients in shaping the care that they receive.", "doi": "10.7861/fhj.2020-0260", "pmid": "33791480", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "futurehealth"}, {"db": "pmc", "key": "PMC8004304"}], "notes": [], "created": "2021-04-06T10:43:07.126Z", "modified": "2021-04-06T10:43:07.149Z"}, {"entity": "publication", "iuid": "7571e2cc6b564849b2e75ed1c8c76404", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7571e2cc6b564849b2e75ed1c8c76404.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7571e2cc6b564849b2e75ed1c8c76404"}}, "title": "Very little influenza in the WHO European Region during the 2020/21 season, weeks 40 2020 to 8 2021.", "authors": [{"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Mook", "given": "Piers", "initials": "P"}, {"family": "Lamb", "given": "Favelle", "initials": "F"}, {"family": "Ferland", "given": "Lisa", "initials": "L"}, {"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "Amato-Gauci", "given": "Andrew J", "initials": "AJ"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "European Influenza Surveillance Network", "given": "", "initials": ""}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "11", "pages": null}, "abstract": "Between weeks 40 2020 and 8 2021, the World Health Organization European Region experienced a 99.8% reduction in sentinel influenza virus positive detections (33/25,606 tested; 0.1%) relative to an average of 14,966/39,407 (38.0%; p < 0.001) over the same time in the previous six seasons. COVID-19 pandemic public health and physical distancing measures may have extinguished the 2020/21 European seasonal influenza epidemic with just a few sporadic detections of all viral subtypes. This might possibly continue during the remainder of the influenza season.", "doi": "10.2807/1560-7917.ES.2021.26.11.2100221", "pmid": "33739256", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-22T10:31:59.380Z", "modified": "2021-06-18T14:39:21.838Z"}, {"entity": "publication", "iuid": "05093540bf5441dfb79be809471bc698", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/05093540bf5441dfb79be809471bc698.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/05093540bf5441dfb79be809471bc698"}}, "title": "Towards a sensitive and accurate interpretation of molecular testing for SARS-CoV-2: a rapid review of 264 studies.", "authors": [{"family": "Stanoeva", "given": "Kamelia R", "initials": "KR"}, {"family": "van der Eijk", "given": "Annemiek A", "initials": "AA"}, {"family": "Meijer", "given": "Adam", "initials": "A"}, {"family": "Kortbeek", "given": "Laetitia M", "initials": "LM"}, {"family": "Koopmans", "given": "Marion P G", "initials": "MPG"}, {"family": "Reusken", "given": "Chantal B E M", "initials": "CBEM"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "10", "issn-l": null}, "abstract": "BackgroundSensitive molecular diagnostics and correct test interpretation are crucial for accurate COVID-19 diagnosis and thereby essential for good clinical practice. Furthermore, they are a key factor in outbreak control where active case finding in combination with isolation and contact tracing are crucial.AimWith the objective to inform the public health and laboratory responses to the pandemic, we reviewed current published knowledge on the kinetics of SARS-CoV-2 infection as assessed by RNA molecular detection in a wide range of clinical samples.MethodsWe performed an extensive search on studies published between 1 December 2019 and 15 May 2020, reporting on molecular detection and/or isolation of SARS-CoV-2 in any human laboratory specimen.ResultsWe compiled a dataset of 264 studies including 32,515 COVID-19 cases, and additionally aggregated data points (n = 2,777) from sampling of 217 adults with known infection timeline. We summarised data on SARS-CoV-2 detection in the respiratory and gastrointestinal tract, blood, oral fluid, tears, cerebrospinal fluid, peritoneal fluid, semen, vaginal fluid; where provided, we also summarised specific observations on SARS-CoV-2 detection in pregnancy, infancy, children, adolescents and immunocompromised individuals.ConclusionOptimal SARS-CoV-2 molecular testing relies on choosing the most appropriate sample type, collected with adequate sampling technique, and with the infection timeline in mind. We outlined knowledge gaps and directions for future well-documented systematic studies.", "doi": "10.2807/1560-7917.ES.2021.26.10.2001134", "pmid": "33706863", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-03-17T07:09:27.560Z", "modified": "2021-03-17T07:09:27.570Z"}, {"entity": "publication", "iuid": "cb6807f591e447ac8b78e9df7a413cd3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cb6807f591e447ac8b78e9df7a413cd3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cb6807f591e447ac8b78e9df7a413cd3"}}, "title": "The new normal of social psychology in the face of the COVID-19 pandemic: Insights and advice from leaders in the field.", "authors": [{"family": "Tam", "given": "Kim-Pong", "initials": "KP"}, {"family": "Leung", "given": "Angela K-Y", "initials": "AK"}, {"family": "Khan", "given": "Sammyh", "initials": "S"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Asian J Soc Psychol", "issn": "1367-2223", "volume": "24", "issue": "1", "pages": "8-9", "issn-l": null}, "abstract": null, "doi": "10.1111/ajsp.12468", "pmid": "33821135", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "AJSP12468"}, {"db": "pmc", "key": "PMC8014449"}], "notes": [], "created": "2021-04-07T10:10:20.671Z", "modified": "2021-04-07T10:10:48.343Z"}, {"entity": "publication", "iuid": "6887e04239de45d69ce855e4c8d0b90f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6887e04239de45d69ce855e4c8d0b90f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6887e04239de45d69ce855e4c8d0b90f"}}, "title": "The Psychological Functioning in the COVID-19 Pandemic and Its Association with Psychological Flexibility and Broader Functioning in People with Chronic Pain", "authors": [{"family": "Yu", "given": "Lin", "initials": "L"}, {"family": "Kioskli", "given": "Kitty", "initials": "K"}, {"family": "McCracken", "given": "Lance M", "initials": "LM"}], "type": "journal-article", "published": "2021-03-00", "journal": {"title": "The Journal of Pain", "issn": "1526-5900", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.jpain.2021.02.011", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-03-09T06:28:16.006Z", "modified": "2021-03-09T06:28:32.481Z"}, {"entity": "publication", "iuid": "5a5780c724224d5eb0b814962d3ac220", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5a5780c724224d5eb0b814962d3ac220.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5a5780c724224d5eb0b814962d3ac220"}}, "title": "Symptom clusters in COVID-19: A potential clinical prediction tool from the COVID Symptom Study app.", "authors": [{"family": "Sudre", "given": "Carole H", "initials": "CH", "orcid": "0000-0001-5753-428X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c26472813fed4007a8757af771de1802.json"}}, {"family": "Lee", "given": "Karla A", "initials": "KA"}, {"family": "Lochlainn", "given": "Mary Ni", "initials": "MN", "orcid": "0000-0001-5702-1759", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07cc5b481cc441988525d0a1b2911a6d.json"}}, {"family": "Varsavsky", "given": "Thomas", "initials": "T"}, {"family": "Murray", "given": "Benjamin", "initials": "B", "orcid": "0000-0002-2413-923X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebec738df0224bf4874fd6c08fd23fae.json"}}, {"family": "Graham", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-4170-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f5f4e19812a46ed9e873732ec25e28d.json"}}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874802ae65824a90ba50eabdeabb8356.json"}}, {"family": "Modat", "given": "Marc", "initials": "M"}, {"family": "Bowyer", "given": "Ruth C E", "initials": "RCE"}, {"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Drew", "given": "David A", "initials": "DA", "orcid": "0000-0002-8813-0816", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd3a2cffdc104f18b8684cf4f27d68b2.json"}}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Ma", "given": "Wenjie", "initials": "W", "orcid": "0000-0001-9894-7072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc7d1aa610c04d67bd6c9b57b34b5ace.json"}}, {"family": "Guo", "given": "Chuan-Guo", "initials": "CG", "orcid": "0000-0002-0657-473X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1be56974ac7414e9db038e4e8c43982.json"}}, {"family": "Lo", "given": "Chun-Han", "initials": "CH", "orcid": "0000-0001-8202-4513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a0d9111318f4084b64f47b5b56c8c85.json"}}, {"family": "Ganesh", "given": "Sajaysurya", "initials": "S", "orcid": "0000-0002-3720-4176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6dbf91180806442082ce6732c1b75923.json"}}, {"family": "Buwe", "given": "Abubakar", "initials": "A", "orcid": "0000-0003-4086-8616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeba04fb389b4d2d8c0e9b29f4424d73.json"}}, {"family": "Pujol", "given": "Joan Capdevila", "initials": "JC"}, {"family": "du Cadet", "given": "Julien Lavigne", "initials": "JL", "orcid": "0000-0001-8034-7167", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd59698f58fa4129a5d07a8315c0c81b.json"}}, {"family": "Visconti", "given": "Alessia", "initials": "A", "orcid": "0000-0003-4144-2019", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ce0429ccf674827aedbb8d05a53145c.json"}}, {"family": "Freidin", "given": "Maxim B", "initials": "MB", "orcid": "0000-0002-1439-6259", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/978702cb6b4c44d7aaa5839543afa5df.json"}}, {"family": "El-Sayed Moustafa", "given": "Julia S", "initials": "JS", "orcid": "0000-0001-6963-6654", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b121ad24f0349a08b785a24a7a1ee3e.json"}}, {"family": "Falchi", "given": "Mario", "initials": "M", "orcid": "0000-0002-5646-1004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0a8220dcbcf45278fa264e153f97650.json"}}, {"family": "Davies", "given": "Richard", "initials": "R", "orcid": "0000-0003-2050-3994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b82cc92615f462d9af0153a6fb94fde.json"}}, {"family": "Gomez", "given": "Maria F", "initials": "MF", "orcid": "0000-0001-6210-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e09e37219c4f42c8a7b3a982da523859.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f34c0d3602439abe6096293c7c732d.json"}}, {"family": "Cardoso", "given": "M Jorge", "initials": "MJ", "orcid": "0000-0003-1284-2558", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0ed3abec67644e186650e1d1dcbbe0b.json"}}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74cf1f7094744ee289fa5df041e7cb5b.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-7284-6767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeefbf47fd384d5390109fe1a903bd18.json"}}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}, {"family": "Ourselin", "given": "S\u00e9bastien", "initials": "S", "orcid": "0000-0002-5694-5340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74c7b9b1633144879042d198c7205656.json"}}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "7", "issue": "12", "issn-l": "2375-2548"}, "abstract": "As no one symptom can predict disease severity or the need for dedicated medical support in coronavirus disease 2019 (COVID-19), we asked whether documenting symptom time series over the first few days informs outcome. Unsupervised time series clustering over symptom presentation was performed on data collected from a training dataset of completed cases enlisted early from the COVID Symptom Study Smartphone application, yielding six distinct symptom presentations. Clustering was validated on an independent replication dataset between 1 and 28 May 2020. Using the first 5 days of symptom logging, the ROC-AUC (receiver operating characteristic - area under the curve) of need for respiratory support was 78.8%, substantially outperforming personal characteristics alone (ROC-AUC 69.5%). Such an approach could be used to monitor at-risk patients and predict medical resource requirements days before they are required.", "doi": "10.1126/sciadv.abd4177", "pmid": "33741586", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7978420"}, {"db": "pii", "key": "7/12/eabd4177"}], "notes": [], "created": "2021-03-22T10:31:12.422Z", "modified": "2023-06-19T15:27:39.430Z"}, {"entity": "publication", "iuid": "de99b38176ee4b739ce67799af265121", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/de99b38176ee4b739ce67799af265121.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/de99b38176ee4b739ce67799af265121"}}, "title": "Sweden: Non-binding Rules against the Pandemic - Formalism, Pragmatism and Some Legal Realism.", "authors": [{"family": "Wenander", "given": "Henrik", "initials": "H"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Eur J Risk Regul", "issn": "1867-299X", "issn-l": null, "volume": "12", "issue": "1", "pages": "127-142"}, "abstract": "Swedish measures to fight the spread of COVID-19 differ from the strategies used in other comparable countries. In contrast to the lockdown approach that has been applied in many European countries, the Swedish strategy has been based to a substantial extent on individuals taking responsibility under non-binding recommendations. This contribution explores the Swedish strategy from a constitutional and administrative law perspective, highlighting the tension between the formalist system for delegating norms under the Swedish Constitution and the pragmatic use of non-binding rules such as the \"General Recommendations\" adopted by the Public Health Agency. The article concludes that the official use of soft law instruments is confusing from a legal perspective, because non-binding rules do not offer the traditional formal mechanisms for legal protection, the publication of norms or accountability. The legal-realist approach of the Supreme Administrative Court's case law, however, has the potential of balancing some of the unfortunate effects arising from the Swedish combination of formalism and pragmatism.", "doi": "10.1017/err.2021.2", "pmid": "34191958", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S1867299X21000027"}, {"db": "pmc", "key": "PMC8060606"}], "notes": [], "created": "2021-07-05T14:25:58.305Z", "modified": "2022-11-23T09:02:34.506Z"}, {"entity": "publication", "iuid": "90e7835a18214ccabf92e7659c5a9709", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90e7835a18214ccabf92e7659c5a9709.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90e7835a18214ccabf92e7659c5a9709"}}, "title": "Shared genetic etiology between idiopathic pulmonary fibrosis and COVID-19 severity", "authors": [{"family": "Fadista", "given": "Jo\u00e3o", "initials": "J", "orcid": "0000-0003-2539-634X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dae453c1a93e417caeb346ac4cdc48ed.json"}}, {"family": "Kraven", "given": "Luke M", "initials": "LM"}, {"family": "Karjalainen", "given": "Juha", "initials": "J"}, {"family": "Andrews", "given": "Shea J", "initials": "SJ"}, {"family": "Geller", "given": "Frank", "initials": "F"}, {"family": "Baillie", "given": "J Kenneth", "initials": "JK"}, {"family": "Wain", "given": "Louise V", "initials": "LV"}, {"family": "Jenkins", "given": "R Gisli", "initials": "RG"}, {"family": "Feenstra", "given": "Bjarke", "initials": "B"}], "type": "journal-article", "published": "2021-03-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": "65", "issue": null, "pages": "103277"}, "abstract": "Idiopathic pulmonary fibrosis (IPF) is a complex lung disease, characterized by progressive lung scarring. Severe COVID-19 is associated with substantial pneumonitis and has a number of shared major risk factors with IPF. This study aimed to determine the genetic correlation between IPF and severe COVID-19 and assess a potential causal role of genetically increased risk of IPF on COVID-19 severity.\r\n\r\nThe genetic correlation between IPF and COVID-19 severity was estimated with linkage disequilibrium (LD) score regression. We performed a Mendelian randomization (MR) study for IPF causality in COVID-19. Genetic variants associated with IPF susceptibility (P<5 \u00d7 10 -8) in previous genome-wide association studies (GWAS) were used as instrumental variables (IVs). Effect estimates of those IVs on COVID-19 severity were gathered from the GWAS meta-analysis by the COVID-19 Host Genetics Initiative (4,336 cases & 623,902 controls).\r\n\r\nWe detected a positive genetic correlation of IPF with COVID-19 severity (rg=0\u00b731 [95% CI 0\u00b704-0\u00b757], P = 0\u00b7023). The MR estimates for severe COVID-19 did not reveal any genetic association (OR 1\u00b705, [95% CI 0\u00b792-1\u00b720], P = 0\u00b743). However, outlier analysis revealed that the IPF risk allele rs35705950 at MUC5B had a different effect compared with the other variants. When rs35705950 was excluded, MR results provided evidence that genetically increased risk of IPF has a causal effect on COVID-19 severity (OR 1\u00b721, [95% CI 1\u00b706-1\u00b738], P = 4\u00b724 \u00d7 10 -3). Furthermore, the IPF risk-allele at MUC5B showed an apparent protective effect against COVID-19 hospitalization only in older adults (OR 0\u00b786, [95% CI 0\u00b773-1\u00b700], P = 2\u00b799 \u00d7 10-2) .\r\n\r\nThe strongest genetic determinant of IPF, rs35705950 at MUC5B, seems to confer protection against COVID-19, whereas the combined effect of all other IPF risk loci seem to confer risk of COVID-19 severity. The observed effect of rs35705950 could either be due to protective effects of mucin over-production on the airways or a consequence of selection bias due to (1) a patient group that is heavily enriched for the rs35705950 T undertaking strict self-isolation and/or (2) due to survival bias of the rs35705950 non-IPF risk allele carriers. Due to the diverse impact of IPF causal variants on SARS-CoV-2 infection, with a possible selection bias as an explanation, further investigation is needed to address this apparent paradox between variance at MUC5B and other IPF genetic risk factors.\r\n\r\nNovo Nordisk Foundation and Oak Foundation.", "doi": "10.1016/j.ebiom.2021.103277", "pmid": "33714028", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "URL", "key": "https://github.com/genomicsITER/PFgenetics", "description": "Variant summary data available on request"}, {"db": "URL", "key": "https://www.covid19hg.org/results/", "description": "COVID-19 Host Genetics Initiative (HGI) GWAS metaanalysis"}], "notes": [], "created": "2021-01-07T16:51:10.098Z", "modified": "2022-07-07T09:55:41.690Z"}, {"entity": "publication", "iuid": "94f5f09c0d0e43ba9e96d2a5e95d0ed4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/94f5f09c0d0e43ba9e96d2a5e95d0ed4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/94f5f09c0d0e43ba9e96d2a5e95d0ed4"}}, "title": "Risk prediction of COVID-19 incidence and mortality in a large multi-national hemodialysis cohort: implications for management of the pandemic in outpatient hemodialysis settings.", "authors": [{"family": "Haarhaus", "given": "Mathias", "initials": "M"}, {"family": "Santos", "given": "Carla", "initials": "C"}, {"family": "Haase", "given": "Michael", "initials": "M"}, {"family": "Mota Veiga", "given": "Pedro", "initials": "P"}, {"family": "Lucas", "given": "Carlos", "initials": "C"}, {"family": "Macario", "given": "Fernando", "initials": "F"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Clin Kidney J", "issn": "2048-8505", "volume": "14", "issue": "3", "pages": "805-813", "issn-l": null}, "abstract": "Experiences from the first wave of the 2019 coronavirus disease (COVID-19) pandemic can aid in the development of future preventive strategies. To date, risk prediction models for COVID-19-related incidence and outcomes in hemodialysis (HD) patients are missing.\n\nWe developed risk prediction models for COVID-19 incidence and mortality among HD patients. We studied 38 256 HD patients from a multi-national dialysis cohort between 3 March and 3 July 2020. Risk prediction models were developed and validated, based on predictors readily available in outpatient HD units. We compared mortality among patients with and without COVID-19, matched for age, sex and diabetes.\n\nDuring the observational period, 1259 patients (3.3%) acquired COVID-19. Of these, 62% were hospitalized or died. Mortality was 22% among COVID-19 patients with odds ratios 219.8 [95% confidence interval (CI) 80.6-359] to 342.7 (95% CI 60.6-13 595.1), compared to matched patients without COVID-19. Since the first wave of the pandemic affected most European countries during the study, the risk prediction model for incidence of COVID-19 was developed and validated in European patients only [ N = 22 826 area under the ROC curve(AUC)Dev 0.64, AUCVal 0.69]. The model for prediction of mortality was developed in all COVID-19 patients (AUCDev 0.71, AUCVal 0.78). Angiotensin receptor blockers were independently associated with a lower incidence of COVID-19 in European patients.\n\nWe identified modifiable risk factors for COVID-19 incidence and outcome in HD patients. Our risk prediction tools can be readily applied in clinical practice. This can aid in the development of preventive strategies for future waves of COVID-19.", "doi": "10.1093/ckj/sfab037", "pmid": "33777363", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "sfab037"}, {"db": "pmc", "key": "PMC7929029"}], "notes": [], "created": "2021-03-30T12:25:19.508Z", "modified": "2021-03-30T12:25:19.524Z"}, {"entity": "publication", "iuid": "c58d689fb71f4c4b80daabc3511108e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c58d689fb71f4c4b80daabc3511108e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c58d689fb71f4c4b80daabc3511108e8"}}, "title": "Risk factors for COVID-19 diagnosis, hospitalization, and subsequent all-cause mortality in Sweden: a nationwide study.", "authors": [{"family": "Bergman", "given": "Jonathan", "initials": "J", "orcid": "0000-0003-1904-6140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/da94cb04b9114549bcc1775090d0de61.json"}}, {"family": "Ballin", "given": "Marcel", "initials": "M", "orcid": "0000-0002-9638-7208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/088ce3ef36e347ebb3a4f90d8e6a1850.json"}}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A", "orcid": "0000-0003-3534-456X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26229455bc3d42f6aea6b541c4d74b48.json"}}, {"family": "Nordstr\u00f6m", "given": "Peter", "initials": "P", "orcid": "0000-0003-2924-508X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1186e45ff19c4b30888c4751faea3c15.json"}}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Eur J Epidemiol", "issn": "1573-7284", "issn-l": "0393-2990", "volume": "36", "issue": "3", "pages": "287-298"}, "abstract": "We conducted a nationwide, registry-based study to investigate the importance of 34 potential risk factors for coronavirus disease 2019 (COVID-19) diagnosis, hospitalization (with or without intensive care unit [ICU] admission), and subsequent all-cause mortality. The study population comprised all COVID-19 cases confirmed in Sweden by mid-September 2020 (68,575 non-hospitalized, 2494 ICU hospitalized, and 13,589 non-ICU hospitalized) and 434,081 randomly sampled general-population controls. Older age was the strongest risk factor for hospitalization, although the odds of ICU hospitalization decreased after 60-69 years and, after controlling for other risk factors, the odds of non-ICU hospitalization showed no trend after 40-49 years. Residence in a long-term care facility was associated with non-ICU hospitalization. Male sex and the presence of at least one investigated comorbidity or prescription medication were associated with both ICU and non-ICU hospitalization. Three comorbidities associated with both ICU and non-ICU hospitalization were asthma, hypertension, and Down syndrome. History of cancer was not associated with COVID-19 hospitalization, but cancer in the past year was associated with non-ICU hospitalization, after controlling for other risk factors. Cardiovascular disease was weakly associated with non-ICU hospitalization for COVID-19, but not with ICU hospitalization, after adjustment for other risk factors. Excess mortality was observed in both hospitalized and non-hospitalized COVID-19 cases. These results confirm that severe COVID-19 is related to age, sex, and comorbidity in general. The study provides new evidence that hypertension, asthma, Down syndrome, and residence in a long-term care facility are associated with severe COVID-19.", "doi": "10.1007/s10654-021-00732-w", "pmid": "33704634", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7946619"}, {"db": "pii", "key": "10.1007/s10654-021-00732-w"}], "notes": [], "created": "2021-03-12T06:42:36.663Z", "modified": "2023-07-13T11:27:54.874Z"}, {"entity": "publication", "iuid": "60be0de57e6441208b155f92091e203b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60be0de57e6441208b155f92091e203b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60be0de57e6441208b155f92091e203b"}}, "title": "Noise measurements as a proxy to evaluating the response to recommendations in times of crisis: An update analysis of the transition to the second wave of the CoViD-19 pandemic in Central Stockholm, Sweden.", "authors": [{"family": "Rumpler", "given": "Romain", "initials": "R"}, {"family": "Venkataraman", "given": "Siddharth", "initials": "S"}, {"family": "G\u00f6ransson", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "J Acoust Soc Am", "issn": "1520-8524", "volume": "149", "issue": "3", "pages": "1838", "issn-l": null}, "abstract": "Sweden stands out among the other European countries by the degree of restrictive measures taken towards handling the 2019 coronavirus outbreak, associated with the CoViD-19 pandemic. While several governments have imposed a nationwide total or partial lockdown to slow down the spread of the virus, the Swedish government has opted for a recommendation-based approach together with a few imposed restrictions. In a previous contribution by the authors, the impact of the Swedish strategy was observed through the monitored variation of the city noise levels during a period associated with the so-called \"first wave\" of the pandemic in Stockholm. A very strong impact of these recommendations was shown on the evolution of the noise levels in central Stockholm. This highlighted the potential of acoustic sensor networks both for enforcement of regulation and monitoring of the effectiveness of their implementation. The present contribution presents a follow-up to this urban noise monitoring in central Stockholm, Sweden, for the period leading to the so-called \"second wave\" of the pandemic in Europe. Both the evolution of adherence to the recommendations and the impact of the recurrence of cases combined with reinforced recommendations are observed through the evolution of the measured noise levels. While the measurements show a gradual lower level of compliance, in particular, past the summer break, these also show again a rapid response to the reinforced recommendations issued by the authorities in mid-fall of 2020. These observations thus confirm the potential associated with detailed urban noise monitoring, for instance here acting as a proxy to evaluating the response to recommendations or restrictions in times of crisis.", "doi": "10.1121/10.0003778", "pmid": "33765773", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-03-29T09:15:50.369Z", "modified": "2021-03-29T09:15:50.385Z"}, {"entity": "publication", "iuid": "4a726c03e1814efc87b21b7679305fcc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4a726c03e1814efc87b21b7679305fcc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4a726c03e1814efc87b21b7679305fcc"}}, "title": "Monitoring of human coronaviruses in Belgian primary care and hospitals, 2015\u201320: a surveillance study", "authors": [{"family": "Fischer", "given": "Natalie", "initials": "N"}, {"family": "Dauby", "given": "Nicolas", "initials": "N"}, {"family": "Bossuyt", "given": "Nathalie", "initials": "N"}, {"family": "Reynders", "given": "Marijke", "initials": "M"}, {"family": "G\u00e9rard", "given": "Mich\u00e8le", "initials": "M"}, {"family": "Lacor", "given": "Patrick", "initials": "P"}, {"family": "Daelemans", "given": "Siel", "initials": "S"}, {"family": "Lissoir", "given": "B\u00e9n\u00e9dicte", "initials": "B"}, {"family": "Holemans", "given": "Xavier", "initials": "X"}, {"family": "Magerman", "given": "Koen", "initials": "K"}, {"family": "Jouck", "given": "Door", "initials": "D"}, {"family": "Bourgeois", "given": "Marc", "initials": "M"}, {"family": "Delaere", "given": "B\u00e9n\u00e9dicte", "initials": "B"}, {"family": "Quoilin", "given": "Sophie", "initials": "S"}, {"family": "Van Gucht", "given": "Steven", "initials": "S"}, {"family": "Thomas", "given": "Isabelle", "initials": "I"}, {"family": "Barbezange", "given": "Cyril", "initials": "C"}, {"family": "Subissi", "given": "Lorenzo", "initials": "L"}], "type": "journal-article", "published": "2021-03-00", "journal": {"title": "The Lancet Microbe", "issn": "2666-5247", "issn-l": "2666-5247", "volume": "2", "issue": "3", "pages": "e105-e114"}, "abstract": "Seasonal human coronaviruses (hCoVs) broadly circulate in humans. Their epidemiology and effect on the spread of emerging coronaviruses has been neglected thus far. We aimed to elucidate the epidemiology and burden of disease of seasonal hCoVs OC43, NL63, and 229E in patients in primary care and hospitals in Belgium between 2015 and 2020.\r\n\r\nWe retrospectively analysed data from the national influenza surveillance networks in Belgium during the winter seasons of 2015-20. Respiratory specimens were collected through the severe acute respiratory infection (SARI) and the influenza-like illness networks from patients with acute respiratory illness with onset within the previous 10 days, with measured or reported fever of 38\u00b0C or greater, cough, or dyspnoea; and for patients admitted to hospital for at least one night. Potential risk factors were recorded and patients who were admitted to hospital were followed up for the occurrence of complications or death for the length of their hospital stay. All samples were analysed by multiplex quantitative RT-PCRs for respiratory viruses, including seasonal hCoVs OC43, NL63, and 229E. We estimated the prevalence and incidence of seasonal hCoV infection, with or without co-infection with other respiratory viruses. We evaluated the association between co-infections and potential risk factors with complications or death in patients admitted to hospital with seasonal hCoV infections by age group. Samples received from week 8, 2020, were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).\r\n\r\n2573 primary care and 6494 hospital samples were included in the study. 161 (6\u00b73%) of 2573 patients in primary care and 371 (5\u00b77%) of 6494 patients admitted to hospital were infected with a seasonal hCoV. OC43 was the seasonal hCoV with the highest prevalence across age groups and highest incidence in children admitted to hospital who were younger than 5 years (incidence 9\u00b70 [95% CI 7\u00b72-11\u00b72] per 100 000 person-months) and adults older than 65 years (2\u00b76 [2\u00b71-3\u00b72] per 100 000 person-months). Among 262 patients admitted to hospital with seasonal hCoV infection and with complete information on potential risk factors, 66 (73\u00b73%) of 90 patients who had complications or died also had at least one potential risk factor (p=0\u00b70064). Complications in children younger than 5 years were associated with co-infection (24 [36\u00b74%] of 66; p=0\u00b7017), and in teenagers and adults (\u226515 years), more complications arose in patients with a single hCoV infection (49 [45\u00b70%] of 109; p=0\u00b70097). In early 2020, the Belgian SARI surveillance detected the first SARS-CoV-2-positive sample concomitantly with the first confirmed COVID-19 case with no travel history to China.\r\n\r\nThe main burden of severe seasonal hCoV infection lies with children younger than 5 years with co-infections and adults aged 65 years and older with pre-existing comorbidities. These age and patient groups should be targeted for enhanced observation when in medical care and in possible future vaccination strategies, and co-infections in children younger than 5 years should be considered during diagnosis and treatment. Our findings support the use of national influenza surveillance systems for seasonal hCoV monitoring and early detection, and monitoring of emerging coronaviruses such as SARS-CoV-2.\r\n\r\nBelgian Federal Public Service Health, Food Chain Safety, and Environment; Belgian National Insurance Health Care (Institut national d'assurance maladie-invalidit\u00e9/Rijksinstituut voor ziekte-en invaliditeitsverzekering); and Regional Health Authorities (Flanders Agentschap zorg en gezondheid, Brussels Commission communautaire commune, Wallonia Agence pour une vie de qualit\u00e9).", "doi": "10.1016/s2666-5247(20)30221-4", "pmid": "33937883", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-05-04T15:57:48.285Z", "modified": "2021-06-18T14:46:29.690Z"}, {"entity": "publication", "iuid": "101f86cc435f4e869f06e10bc5689df5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/101f86cc435f4e869f06e10bc5689df5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/101f86cc435f4e869f06e10bc5689df5"}}, "title": "Interactions between seasonal human coronaviruses and implications for the SARS-CoV-2 pandemic: A retrospective study in Stockholm, Sweden, 2009-2020.", "authors": [{"family": "Dyrdak", "given": "Robert", "initials": "R", "orcid": "0000-0001-8456-4898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98ad76a0e144478cb3ceabd05c9928b0.json"}}, {"family": "Hodcroft", "given": "Emma B", "initials": "EB", "orcid": "0000-0002-0078-2212", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/563993c9fb68466c8867ca7600733548.json"}}, {"family": "Wahlund", "given": "Martina", "initials": "M"}, {"family": "Neher", "given": "Richard A", "initials": "RA", "orcid": "0000-0003-2525-1407", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a31564f19214fbdb275578ed05a6bcb.json"}}, {"family": "Albert", "given": "Jan", "initials": "J", "orcid": "0000-0001-9020-0521", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79a6c7eedadb4a1e8c6fd7b8b522a8e3.json"}}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "J Clin Virol", "issn": "1873-5967", "volume": "136", "issue": null, "pages": "104754", "issn-l": null}, "abstract": "The four seasonal coronaviruses 229E, NL63, OC43, and HKU1 are frequent causes of respiratory infections and show annual and seasonal variation. Increased understanding about these patterns could be informative about the epidemiology of SARS-CoV-2.\n\nResults from PCR diagnostics for the seasonal coronaviruses, and other respiratory viruses, were obtained for 55,190 clinical samples analyzed at the Karolinska University Hospital, Stockholm, Sweden, between 14 September 2009 and 2 April 2020.\n\nSeasonal coronaviruses were detected in 2130 samples (3.9 %) and constituted 8.1 % of all virus detections. OC43 was most commonly detected (28.4 % of detections), followed by NL63 (24.0 %), HKU1 (17.6 %), and 229E (15.3 %). The overall fraction of positive samples was similar between seasons, but at species level there were distinct biennial alternating peak seasons for the Alphacoronaviruses, 229E and NL63, and the Betacoronaviruses, OC43 and HKU1, respectively. The Betacoronaviruses peaked earlier in the winter season (Dec-Jan) than the Alphacoronaviruses (Feb-Mar). Coronaviruses were detected across all ages, but diagnostics were more frequently requested for paediatric patients than adults and the elderly. OC43 and 229E incidence was relatively constant across age strata, while that of NL63 and HKU1 decreased with age.\n\nBoth the Alphacoronaviruses and Betacoronaviruses showed alternating biennial winter incidence peaks, which suggests some type of immune mediated interaction. Symptomatic reinfections in adults and the elderly appear relatively common. Both findings may be of relevance for the epidemiology of SARS-CoV-2.", "doi": "10.1016/j.jcv.2021.104754", "pmid": "33601153", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pmc", "key": "PMC7869750"}, {"db": "pii", "key": "S1386-6532(21)00021-4"}], "notes": [], "created": "2021-02-19T14:05:54.744Z", "modified": "2023-06-19T14:44:22.357Z"}, {"entity": "publication", "iuid": "7d04c0dd10e84d5a812d21d4b41b5fd2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d04c0dd10e84d5a812d21d4b41b5fd2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d04c0dd10e84d5a812d21d4b41b5fd2"}}, "title": "Global Tuberculosis Report 2020 \u2013 Reflections on the Global TB burden, treatment and prevention efforts", "authors": [{"family": "Chakaya", "given": "Jeremiah", "initials": "J"}, {"family": "Khan", "given": "Mishal", "initials": "M"}, {"family": "Ntoumi", "given": "Francine", "initials": "F"}, {"family": "Aklillu", "given": "Eleni", "initials": "E"}, {"family": "Fatima", "given": "Razia", "initials": "R"}, {"family": "Mwaba", "given": "Peter", "initials": "P"}, {"family": "Kapata", "given": "Nathan", "initials": "N"}, {"family": "Mfinanga", "given": "Sayoki", "initials": "S"}, {"family": "Hasnain", "given": "Seyed Ehtesham", "initials": "SE"}, {"family": "Katoto", "given": "Patrick D M C", "initials": "PDMC"}, {"family": "Bulabula", "given": "Andr\u00e9 N H", "initials": "ANH"}, {"family": "Sam-Agudu", "given": "Nadia A", "initials": "NA"}, {"family": "Nachega", "given": "Jean B", "initials": "JB"}, {"family": "Tiberi", "given": "Simon", "initials": "S"}, {"family": "McHugh", "given": "Timothy D", "initials": "TD"}, {"family": "Abubakar", "given": "Ibrahim", "initials": "I"}, {"family": "Zumla", "given": "Alimuddin", "initials": "A"}], "type": "journal-article", "published": "2021-03-00", "journal": {"title": "Int J Infect Dis", "issn": "1201-9712", "volume": null, "issue": null, "issn-l": null}, "abstract": "The October 2020 Global TB report reviews TB control strategies and United Nations (UN) targets set in the political declaration at the September 2018 UN General Assembly high-level meeting on TB held in New York. Progress in TB care and prevention has been very slow. In 2019, TB remained the most common cause of death from a single infectious pathogen. Globally, an estimated 10.0 million people developed TB disease in 2019, and there were an estimated 1.2 million TB deaths among HIV-negative people and an additional 208, 000 deaths among people living with HIV. Adults accounted for 88% and children for 12% of people with TB. The WHO regions of South-East Asia (44%), Africa (25%), and the Western Pacific (18%) had the most people with TB. Eight countries accounted for two thirds of the global total: India (26%), Indonesia (8.5%), China (8.4%), the Philippines (6.0%), Pakistan (5.7%), Nigeria (4.4%), Bangladesh (3.6%) and South Africa (3.6%). Only 30% of the 3.5 million five-year target for children treated for TB was met. Major advances have been development of new all oral regimens for MDRTB and new regimens for preventive therapy. In 2020, the COVID-19 pandemic dislodged TB from the top infectious disease cause of mortality globally. Notably, global TB control efforts were not on track even before the advent of the COVID-19 pandemic. Many challenges remain to improve sub-optimal TB treatment and prevention services. Tuberculosis screening and diagnostic test services need to be ramped up. The major drivers of TB remain undernutrition, poverty, diabetes, tobacco smoking, and household air pollution and these need be addressed to achieve the WHO 2035 TB care and prevention targets. National programs need to include interventions for post-tuberculosis holistic wellbeing. From first detection of COVID-19 global coordination and political will with huge financial investments have led to the development of effective vaccines against SARS-CoV2 infection. The world now needs to similarly focus on development of new vaccines for TB utilizing new technological methods.", "doi": "10.1016/j.ijid.2021.02.107", "pmid": "33716195", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)00193-4"}], "notes": [], "created": "2021-03-17T07:44:20.760Z", "modified": "2021-11-18T12:57:11.611Z"}, {"entity": "publication", "iuid": "32060e12cef54c949408c3780679c265", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/32060e12cef54c949408c3780679c265.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/32060e12cef54c949408c3780679c265"}}, "title": "Emerging COVID-19 impacts, responses, and lessons for building resilience in the seafood system.", "authors": [{"family": "Love", "given": "David C", "initials": "DC"}, {"family": "Allison", "given": "Edward H", "initials": "EH"}, {"family": "Asche", "given": "Frank", "initials": "F"}, {"family": "Belton", "given": "Ben", "initials": "B"}, {"family": "Cottrell", "given": "Richard S", "initials": "RS"}, {"family": "Froehlich", "given": "Halley E", "initials": "HE"}, {"family": "Gephart", "given": "Jessica A", "initials": "JA"}, {"family": "Hicks", "given": "Christina C", "initials": "CC"}, {"family": "Little", "given": "David C", "initials": "DC"}, {"family": "Nussbaumer", "given": "Elizabeth M", "initials": "EM"}, {"family": "Pinto da Silva", "given": "Patricia", "initials": "P"}, {"family": "Poulain", "given": "Florence", "initials": "F"}, {"family": "Rubio", "given": "Angel", "initials": "A"}, {"family": "Stoll", "given": "Joshua S", "initials": "JS"}, {"family": "Tlusty", "given": "Michael F", "initials": "MF"}, {"family": "Thorne-Lyman", "given": "Andrew L", "initials": "AL"}, {"family": "Troell", "given": "Max", "initials": "M"}, {"family": "Zhang", "given": "Wenbo", "initials": "W"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Glob Food Sec", "issn": "2211-9124", "volume": "28", "pages": "100494", "issn-l": null}, "abstract": "The COVID-19 pandemic and subsequent lockdowns are creating health and economic crises that threaten food and nutrition security. The seafood sector provides important sources of nutrition and employment, especially in low-income countries, and is highly globalized allowing shocks to propagate. We studied COVID-19-related disruptions, impacts, and responses to the seafood sector from January through May 2020, using a food system resilience 'action cycle' framework as a guide. We find that some supply chains, market segments, companies, small-scale actors and civil society have shown initial signs of greater resilience than others. COVID-19 has also highlighted the vulnerability of certain groups working in- or dependent on the seafood sector. We discuss early coping and adaptive responses combined with lessons from past shocks that could be considered when building resilience in the sector. We end with strategic research needs to support learning from COVID-19 impacts and responses.", "doi": "10.1016/j.gfs.2021.100494", "pmid": "34513582", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2211-9124(21)00004-3"}, {"db": "pmc", "key": "PMC8417121"}], "notes": [], "created": "2021-09-20T06:33:28.865Z", "modified": "2021-09-20T06:33:28.892Z"}, {"entity": "publication", "iuid": "9931f188999f44fba834cbe17b7ac2d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9931f188999f44fba834cbe17b7ac2d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9931f188999f44fba834cbe17b7ac2d9"}}, "title": "COVID-19: cross-border contact tracing in Germany, February to April 2020.", "authors": [{"family": "Markus", "given": "Inessa", "initials": "I"}, {"family": "Steffen", "given": "Gyde", "initials": "G"}, {"family": "Lachmann", "given": "Raskit", "initials": "R"}, {"family": "Marquis", "given": "Adine", "initials": "A"}, {"family": "Schneider", "given": "Timm", "initials": "T"}, {"family": "Tomczyk", "given": "Sara", "initials": "S"}, {"family": "Koppe", "given": "Uwe", "initials": "U"}, {"family": "Rohde", "given": "Anna M", "initials": "AM"}, {"family": "Schink", "given": "Susanne Barbara", "initials": "SB"}, {"family": "Seifried", "given": "Janna", "initials": "J"}, {"family": "Domaszewska", "given": "Teresa", "initials": "T"}, {"family": "Rexroth", "given": "Ute", "initials": "U"}, {"family": "An der Heiden", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "10", "pages": null}, "abstract": "IntroductionThe Robert Koch Institute (RKI) managed the exchange of cross-border contact tracing data between public health authorities (PHA) in Germany and abroad during the early COVID-19 pandemic.AimWe describe the extent of cross-border contact tracing and its challenges.MethodsWe analysed cross-border COVID-19 contact tracing events from 3 February to 5 April 2020 using information exchanged through the European Early Warning Response System and communication with International Health Regulation national focal points. We described events by PHA, number of contacts and exposure context.ResultsThe RKI processed 467 events, initiating contact to PHA 1,099 times (median = 1; interquartile range (IQR): 1-2) and sharing data on 5,099 contact persons. Of 327 (70%) events with known exposure context, the most commonly reported exposures were aircraft (n = 64; 20%), cruise ships (n = 24; 7%) and non-transport contexts (n = 210; 64%). Cruise ship and aircraft exposures generated more contacts with authorities (median = 10; IQR: 2-16, median = 4; IQR: 2-11) and more contact persons (median = 60; IQR: 9-269, median = 2; IQR: 1-3) than non-transport exposures (median = 1; IQR: 1-6 and median = 1; IQR: 1-2). The median time spent on contact tracing was highest for cruise ships: 5 days (IQR: 3-9).ConclusionIn the COVID-19 pandemic, cross-border contact tracing is considered a critical component of the outbreak response. While only a minority of international contact tracing activities were related to exposure events in transport, they contributed substantially to the workload. The numerous communications highlight the need for fast and efficient global outbreak communication channels between PHA.", "doi": "10.2807/1560-7917.ES.2021.26.10.2001236", "pmid": "33706859", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-17T07:08:26.792Z", "modified": "2021-06-18T14:35:54.846Z"}, {"entity": "publication", "iuid": "fa577d8d62b147619aef4361d53d40ea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa577d8d62b147619aef4361d53d40ea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa577d8d62b147619aef4361d53d40ea"}}, "title": "ARIA-EAACI statement on asthma and COVID-19 (June 2, 2020).", "authors": [{"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Jutel", "given": "Marek", "initials": "M"}, {"family": "Akdis", "given": "Cezmi A", "initials": "CA", "orcid": "0000-0001-8020-019X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1c16696cf404e6ebd2a06c63b8d9849.json"}}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Pfaar", "given": "Oliver", "initials": "O", "orcid": "0000-0003-4374-9639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b23ecb478474bd18839b7ecaced7f08.json"}}, {"family": "Nadeau", "given": "Kari C", "initials": "KC", "orcid": "0000-0002-2146-2955", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/23da79d94ab448f49859abb68f851e31.json"}}, {"family": "Eiwegger", "given": "Thomas", "initials": "T", "orcid": "0000-0002-2914-7829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c90e67dd0a5451a9c95ea4570834cb9.json"}}, {"family": "Bedbrook", "given": "Anna", "initials": "A"}, {"family": "Ansotegui", "given": "Ignacio J", "initials": "IJ"}, {"family": "Anto", "given": "Josep M", "initials": "JM"}, {"family": "Bachert", "given": "Claus", "initials": "C", "orcid": "0000-0003-4742-1665", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac2485abcc7646aebe7330c514b47c29.json"}}, {"family": "Bateman", "given": "Eric D", "initials": "ED"}, {"family": "Bennoor", "given": "Kazi S", "initials": "KS"}, {"family": "Berghea", "given": "Elena Camelia", "initials": "EC"}, {"family": "Bergmann", "given": "Karl-Christian", "initials": "KC", "orcid": "0000-0002-0306-9922", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f09bd15c861743a7851bde407356fb6b.json"}}, {"family": "Blain", "given": "Hubert", "initials": "H"}, {"family": "Bonini", "given": "Mateo", "initials": "M", "orcid": "0000-0002-3042-0765", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb9057d6fa3d4f4ea86351af45ce21bc.json"}}, {"family": "Bosnic-Anticevich", "given": "Sinthia", "initials": "S"}, {"family": "Boulet", "given": "Louis-Philippe", "initials": "LP", "orcid": "0000-0003-3485-9393", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/997f95adb7f34198a9c837217332fae2.json"}}, {"family": "Brussino", "given": "Luisa", "initials": "L"}, {"family": "Buhl", "given": "Roland", "initials": "R"}, {"family": "Camargos", "given": "Paulo", "initials": "P"}, {"family": "Canonica", "given": "Giorgio Walter", "initials": "GW"}, {"family": "Cardona", "given": "Victoria", "initials": "V", "orcid": "0000-0003-2197-9767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80cffee5190f476d99c541a2282fd0d4.json"}}, {"family": "Casale", "given": "Thomas", "initials": "T", "orcid": "0000-0002-3149-7377", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba9ce0f5cdc4473395b7f0991abdc9ba.json"}}, {"family": "Chinthrajah", "given": "Sharon", "initials": "S"}, {"family": "Akdis", "given": "M\u00fcbeccel", "initials": "M", "orcid": "0000-0003-0554-9943", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3e08fc9040548058d7c21f7b3931dbe.json"}}, {"family": "Chivato", "given": "Tomas", "initials": "T"}, {"family": "Christoff", "given": "George", "initials": "G"}, {"family": "Cruz", "given": "Alvaro A", "initials": "AA", "orcid": "0000-0002-7403-3871", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/befa954a45424a7ea1b84e55e9bcdccb.json"}}, {"family": "Czarlewski", "given": "Wienczyslawa", "initials": "W"}, {"family": "Del Giacco", "given": "Stefano", "initials": "S"}, {"family": "Du", "given": "Hui", "initials": "H"}, {"family": "El-Gamal", "given": "Yehia", "initials": "Y"}, {"family": "Fokkens", "given": "Wytske J", "initials": "WJ", "orcid": "0000-0003-4852-229X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1a5bcdc04b0454392dbb1c6a9c003cf.json"}}, {"family": "Fonseca", "given": "Joao A", "initials": "JA"}, {"family": "Gao", "given": "Yadong", "initials": "Y"}, {"family": "Gaga", "given": "Mina", "initials": "M"}, {"family": "Gemicioglu", "given": "Bilun", "initials": "B"}, {"family": "Gotua", "given": "Maia", "initials": "M", "orcid": "0000-0003-2497-4128", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb1141c3d0e14b53a4c2dce6166d634a.json"}}, {"family": "Haahtela", "given": "Tari", "initials": "T", "orcid": "0000-0003-4757-2156", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/339da718bfb24a95b2920bc60429c314.json"}}, {"family": "Halpin", "given": "David", "initials": "D"}, {"family": "Hamelmann", "given": "Eckard", "initials": "E", "orcid": "0000-0002-2996-8248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e21761fe26845dbaa8d962408ad97ff.json"}}, {"family": "Hoffmann-Sommergruber", "given": "Karin", "initials": "K"}, {"family": "Humbert", "given": "Marc", "initials": "M"}, {"family": "Ilina", "given": "Nataliya", "initials": "N"}, {"family": "Ivancevich", "given": "Juan-Carlos", "initials": "JC"}, {"family": "Joos", "given": "Guy", "initials": "G"}, {"family": "Khaitov", "given": "Musa", "initials": "M"}, {"family": "Kirenga", "given": "Bruce", "initials": "B"}, {"family": "Knol", "given": "Edward F", "initials": "EF"}, {"family": "Ko", "given": "Fanny W", "initials": "FW"}, {"family": "Koskinen", "given": "Seppo", "initials": "S"}, {"family": "Kowalski", "given": "Marek L", "initials": "ML"}, {"family": "Kraxner", "given": "Helga", "initials": "H"}, {"family": "Kudlay", "given": "Dmitry", "initials": "D", "orcid": "0000-0003-1878-4467", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d3e6e559aae24655870f855046230f21.json"}}, {"family": "Kuna", "given": "Piotr", "initials": "P"}, {"family": "Kupczyk", "given": "Maciej", "initials": "M"}, {"family": "Kvedariene", "given": "Violeta", "initials": "V"}, {"family": "Abdul Latiff", "given": "Amir H", "initials": "AH"}, {"family": "Le", "given": "Lan T", "initials": "LT"}, {"family": "Levin", "given": "Michael", "initials": "M", "orcid": "0000-0003-2439-7981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56d68a2cbab745dd8745c99e6acea42f.json"}}, {"family": "Larenas-Linnemann", "given": "Desiree", "initials": "D", "orcid": "0000-0002-5713-5331", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8ffe8940cf9462e86211ff56b10528f.json"}}, {"family": "Louis", "given": "Renaud", "initials": "R"}, {"family": "Masjedi", "given": "Mohammad R", "initials": "MR"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Mihaltan", "given": "Florin", "initials": "F"}, {"family": "Milenkovic", "given": "Branislava", "initials": "B"}, {"family": "Mohammad", "given": "Yousser", "initials": "Y"}, {"family": "Morais-Almeida", "given": "Mario", "initials": "M", "orcid": "0000-0003-1837-2980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/642d46cfd0f54668a32f1baab68ba33d.json"}}, {"family": "Mullol", "given": "Joaquim", "initials": "J"}, {"family": "Namazova", "given": "Leyla", "initials": "L"}, {"family": "Neffen", "given": "Hugo", "initials": "H"}, {"family": "Nunes", "given": "Elisabete", "initials": "E"}, {"family": "O'Byrne", "given": "Paul", "initials": "P"}, {"family": "O'Hehir", "given": "Robyn", "initials": "R"}, {"family": "O'Mahony", "given": "Liam", "initials": "L"}, {"family": "Ohta", "given": "Ken", "initials": "K", "orcid": "0000-0001-9734-4579", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/465a0478a3b047ae8d6845f61380256d.json"}}, {"family": "Okamoto", "given": "Yoshitaka", "initials": "Y"}, {"family": "Onorato", "given": "Gabrielle L", "initials": "GL"}, {"family": "Panzner", "given": "Petr", "initials": "P"}, {"family": "Papadopoulos", "given": "Nikos G", "initials": "NG", "orcid": "0000-0002-4448-3468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c15c79dff08b458fa296e513201635be.json"}}, {"family": "Passalacqua", "given": "Gianni", "initials": "G", "orcid": "0000-0002-5139-3604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a7d959168ef499a8f2a2b576de11ad0.json"}}, {"family": "Patella", "given": "Vincenzo", "initials": "V", "orcid": "0000-0001-5640-6446", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/decdadd477b4440695714b4a9bbf609a.json"}}, {"family": "Pawankar", "given": "Ruby", "initials": "R"}, {"family": "Pham-Thi", "given": "Nh\u00e2n", "initials": "N"}, {"family": "Pigearias", "given": "Bernard", "initials": "B"}, {"family": "Popov", "given": "Todor A", "initials": "TA"}, {"family": "Puggioni", "given": "Francesca", "initials": "F"}, {"family": "Regateiro", "given": "Frederico S", "initials": "FS"}, {"family": "Rolla", "given": "Giovanni", "initials": "G"}, {"family": "Rottem", "given": "Menachem", "initials": "M"}, {"family": "Samolinski", "given": "Boleslaw", "initials": "B"}, {"family": "Sastre", "given": "Joaquin", "initials": "J", "orcid": "0000-0003-4689-6837", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03ef6cc3dbfb4764905e593f210e7759.json"}}, {"family": "Schwarze", "given": "Jurgen", "initials": "J"}, {"family": "Sheikh", "given": "Aziz", "initials": "A"}, {"family": "Scichilone", "given": "Nicola", "initials": "N"}, {"family": "Soto-Quiros", "given": "Manuel", "initials": "M"}, {"family": "Soto-Martinez", "given": "Manuel", "initials": "M"}, {"family": "Sova", "given": "Milan", "initials": "M"}, {"family": "Nicola", "given": "Stefania", "initials": "S"}, {"family": "Stelmach", "given": "Rafael", "initials": "R"}, {"family": "Suppli-Ulrik", "given": "Charlotte", "initials": "C"}, {"family": "Taborda-Barata", "given": "Luis", "initials": "L"}, {"family": "To", "given": "Teresa", "initials": "T"}, {"family": "Tomazic", "given": "Peter-Valentin", "initials": "PV", "orcid": "0000-0001-6445-4800", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e57596e0a1974baf85e37fcf8195f7b9.json"}}, {"family": "Toppila-Salmi", "given": "Sanna", "initials": "S", "orcid": "0000-0003-0890-6686", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d947e332e4341309f076161a3052a9d.json"}}, {"family": "Tsiligianni", "given": "Ioanna", "initials": "I"}, {"family": "Usmani", "given": "Omar", "initials": "O"}, {"family": "Valiulis", "given": "Arunas", "initials": "A"}, {"family": "Ventura", "given": "Maria Teresa", "initials": "MT"}, {"family": "Viegi", "given": "Giovanni", "initials": "G"}, {"family": "Vontetsianos", "given": "Theodor", "initials": "T"}, {"family": "Wang", "given": "De Yun", "initials": "Y"}, {"family": "Williams", "given": "Sian", "initials": "S"}, {"family": "Wong", "given": "Gary W K", "initials": "GWK", "orcid": "0000-0001-5939-812X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a7be3acc778435bb925e8c671876b8c.json"}}, {"family": "Yorgancioglu", "given": "Arzu", "initials": "A"}, {"family": "Zernotti", "given": "Mario", "initials": "M"}, {"family": "Zidarn", "given": "Mihaela", "initials": "M"}, {"family": "Zuberbier", "given": "Torsten", "initials": "T", "orcid": "0000-0002-1466-8875", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7dc091f64a240fd8fb6443292b812c6.json"}}, {"family": "Agache", "given": "Ioana", "initials": "I", "orcid": "0000-0001-7994-364X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25d9598f74414a38a868c2bcf545e94d.json"}}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": "76", "issue": "3", "pages": "689-697", "issn-l": "0105-4538"}, "abstract": null, "doi": "10.1111/all.14471", "pmid": "32588922", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7361514"}], "notes": [], "created": "2020-12-08T15:47:32.488Z", "modified": "2023-06-19T14:56:33.583Z"}, {"entity": "publication", "iuid": "fbd0f47a2fe447f4bbadac01d12693b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fbd0f47a2fe447f4bbadac01d12693b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fbd0f47a2fe447f4bbadac01d12693b1"}}, "title": "Racial and ethnic differences in COVID-19 vaccine hesitancy and uptake", "authors": [{"family": "Nguyen", "given": "Long H", "initials": "LH"}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Merino", "given": "Jordi", "initials": "J"}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Lo", "given": "Chun Han", "initials": "CH"}, {"family": "Kwon", "given": "Sohee", "initials": "S"}, {"family": "Wang", "given": "Kai", "initials": "K"}, {"family": "Graham", "given": "Mark S", "initials": "MS"}, {"family": "Polidori", "given": "Lorenzo", "initials": "L"}, {"family": "Menni", "given": "Cristina", "initials": "C"}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Anyane-Yeboa", "given": "Adjoa", "initials": "A"}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Warner", "given": "Erica T", "initials": "ET"}, {"family": "Hu", "given": "Christina Y", "initials": "CY"}, {"family": "Selvachandran", "given": "Somesh", "initials": "S"}, {"family": "Davies", "given": "Richard", "initials": "R"}, {"family": "Nash", "given": "Denis", "initials": "D"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Spector", "given": "Tim D", "initials": "TD"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}], "type": "posted-content", "published": "2021-02-28", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.25.21252402", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-10T15:04:30.526Z", "modified": "2021-03-12T10:08:58.796Z"}, {"entity": "publication", "iuid": "abda60f2e6fa4991907b165c02f376c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abda60f2e6fa4991907b165c02f376c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abda60f2e6fa4991907b165c02f376c5"}}, "title": "Changes of Gambling Patterns during COVID-19 in Sweden, and Potential for Preventive Policy Changes. A Second Look Nine Months into the Pandemic.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "Widinghoff", "given": "Carolina", "initials": "C"}], "type": "journal article", "published": "2021-02-27", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "5", "pages": null}, "abstract": "Gambling has been suggested as one of the potential mental health consequences of the COVID-19 pandemic. In earlier self-report studies, increased gambling has been reported by a limited proportion of respondents characterized with a high degree of problem gambling. The present study, carried out with the same methodology and in the same geographical setting, around seven months later in the pandemic, aimed to repeat and to extend the understanding of potential gambling changes in the population during COVID-19. An anonymous sample of web panel members was assessed, altogether 2029 individuals (52% women, 10% moderate-risk or problem gamblers). Results indicated that 6% reported increased gambling, and 4% reported decreased gambling during the pandemic. Having increased gambling was associated with more severe gambling problems (OR 2.78, 95% confidence interval 2.27-3.40), increased alcohol consumption (OR 2.92, 1.71-4.98), and psychological distress (OR 3.38, 1.83-6.23). In the group reporting increased gambling during COVID-19, moderate-risk/problem gambling was very common (62%). Recent governmental policy interventions in the area were known to a minority (30%) of respondents, but awareness of the regulations was markedly more common in individuals with at least moderate-risk gambling (56%) and in self-excluders (78%). Reporting of any perceived influence from policy changes was low (3%), and divided between those reporting an increasing and decreasing effect, respectively. Increased gambling may be a consequence of COVID-19-related changes in everyday lives of individuals with problematic gambling patterns. Thus, a vulnerable group demonstrates higher rates of gambling migration and psychosocial problems, and may require particular attention in screening and treatment contexts, and further scientific evaluations.", "doi": "10.3390/ijerph18052342", "pmid": "33673575", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph18052342"}], "notes": [], "created": "2021-03-08T10:53:43.655Z", "modified": "2021-06-18T14:31:03.572Z"}, {"entity": "publication", "iuid": "5d070ba5bf81463dbb738f0abdd09039", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d070ba5bf81463dbb738f0abdd09039.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d070ba5bf81463dbb738f0abdd09039"}}, "title": "COVID-19 Vaccines: Global Challenges and Prospects Forum Recommendations.", "authors": [{"family": "Boudjelal", "given": "Mohamed", "initials": "M"}, {"family": "Almajed", "given": "Faisal", "initials": "F"}, {"family": "Salman", "given": "Ahmed M", "initials": "AM"}, {"family": "Alharbi", "given": "Naif K", "initials": "NK"}, {"family": "Colangelo", "given": "Margaretta", "initials": "M"}, {"family": "Michelotti", "given": "Julia M", "initials": "JM"}, {"family": "Olinger", "given": "Gene", "initials": "G"}, {"family": "Baker", "given": "Mariwan", "initials": "M"}, {"family": "Hill", "given": "Adrian V S", "initials": "AVS"}, {"family": "Alaskar", "given": "Ahmed", "initials": "A"}], "type": "journal article", "published": "2021-02-27", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "volume": null, "issue": null, "issn-l": "1201-9712"}, "abstract": "Perspective On November 4 and 5, 2020 the 11 th Annual KAIMRC Global Forum was organized as a G20 related event entitled COVID-19 Vaccines: Global Challenges and Prospects, https://globalcovid19vaccines.com. It was a vital event that provided a hub for leading COVID-19 scientists, regulators, pharmaceutical representative, funders and charities to learn about COVID-19 vaccines in development, discuss different vaccine candidates, make recommendations, highlight lessons learned and address appropriate plans for global distribution and pricing. Over 10,000 people from 94 countries attended the forum. The leading COVID-19 vaccines presented use different technologies including: (a) Non-replicating viral vector based vaccines, ChAdOx1 nCoV-19/AZD1222 vaccine developed by Oxford-AstraZeneca (van Doremalen et al., 2020), the Sputnik V developed by the Russian Gamaleya Institute consisting of two components, a recombinant adenovirus type 26 (rAd26) vector and a recombinant adenovirus type 5 (rAd5) vector (Logunov et al., 2020), and the Ad26.COV2.S developed by Center for Virology and Vaccine Research, at Harvard Medical School in collaboration with Janssen Vaccines and Prevention BV, Leiden (Mercado et al., 2020). (b) Nucleic Acid, DNA- or RNA- based Vaccines that include the mRNA-1273 vaccine that is being developed by Moderna (Anderson et al., 2020), and a self-amplifying (saRNA) vaccine termed VGHsa111 developed by Imperial College, London as well as another co-developed by Pfizer and Biontech. An example of a DNA based vaccine against COVID19 is INO-4800 that is being developed by Inovio Pharmaceuticals Inc. (Smith et al., 2020). (c) Protein based vaccines, CoV RBD219-N1 Vaccine from Baylor College of Medicine, Texas that is based on a yeast-derived (Pichia pastoris) protein (Hotez and Bottazzi, 2020) and from Anhui Zhifei Longcom Biopharmaceutical Co. Ltd (Dai et al., 2020). Representatives from the Bill & Melinda Gates Foundation, the Bring Hope Humanitarian Foundation (BHHF), and the Coalition for Epidemic Preparedness Innovations (CEPI), presented their plans for distributing the vaccines to people in need around the world including the low-income countries. They are also developing educational programs to train health workers in immunization procedures.", "doi": "10.1016/j.ijid.2021.02.093", "pmid": "33652065", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)00179-X"}], "notes": [], "created": "2021-03-03T17:01:09.572Z", "modified": "2021-03-03T17:01:09.582Z"}, {"entity": "publication", "iuid": "3d00241e04a747daba93735a14a4a98a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3d00241e04a747daba93735a14a4a98a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3d00241e04a747daba93735a14a4a98a"}}, "title": "In silico Analyses of Immune System Protein Interactome Network, Single-Cell RNA Sequencing of Human Tissues, and Artificial Neural Networks Reveal Potential Therapeutic Targets for Drug Repurposing Against COVID-19.", "authors": [{"family": "L\u00f3pez-Cort\u00e9s", "given": "Andr\u00e9s", "initials": "A"}, {"family": "Guevara-Ram\u00edrez", "given": "Patricia", "initials": "P"}, {"family": "Kyriakidis", "given": "Nikolaos C", "initials": "NC"}, {"family": "Barba-Ostria", "given": "Carlos", "initials": "C"}, {"family": "Le\u00f3n C\u00e1ceres", "given": "\u00c1ngela", "initials": "\u00c1"}, {"family": "Guerrero", "given": "Santiago", "initials": "S"}, {"family": "Ortiz-Prado", "given": "Esteban", "initials": "E"}, {"family": "Munteanu", "given": "Cristian R", "initials": "CR"}, {"family": "Tejera", "given": "Eduardo", "initials": "E"}, {"family": "Cevallos-Robalino", "given": "Dom\u00e9nica", "initials": "D"}, {"family": "G\u00f3mez-Jaramillo", "given": "Ana Mar\u00eda", "initials": "AM"}, {"family": "Simba\u00f1a-Rivera", "given": "Katherine", "initials": "K"}, {"family": "Granizo-Mart\u00ednez", "given": "Adriana", "initials": "A"}, {"family": "P\u00e9rez-M", "given": "Gabriela", "initials": "G"}, {"family": "Moreno", "given": "Silvana", "initials": "S"}, {"family": "Garc\u00eda-C\u00e1rdenas", "given": "Jennyfer M", "initials": "JM"}, {"family": "Zambrano", "given": "Ana Karina", "initials": "AK"}, {"family": "P\u00e9rez-Castillo", "given": "Yunierkis", "initials": "Y"}, {"family": "Cabrera-Andrade", "given": "Alejandro", "initials": "A"}, {"family": "Puig San Andr\u00e9s", "given": "Lourdes", "initials": "L"}, {"family": "Proa\u00f1o-Castro", "given": "Carolina", "initials": "C"}, {"family": "Bautista", "given": "Jhommara", "initials": "J"}, {"family": "Quevedo", "given": "Andreina", "initials": "A"}, {"family": "Varela", "given": "Nelson", "initials": "N"}, {"family": "Qui\u00f1ones", "given": "Luis Abel", "initials": "LA"}, {"family": "Paz-Y-Mi\u00f1o", "given": "C\u00e9sar", "initials": "C"}], "type": "journal article", "published": "2021-02-26", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "12", "issue": null, "pages": "598925", "issn-l": "1663-9812"}, "abstract": "Background: There is pressing urgency to identify therapeutic targets and drugs that allow treating COVID-19 patients effectively. Methods: We performed in silico analyses of immune system protein interactome network, single-cell RNA sequencing of human tissues, and artificial neural networks to reveal potential therapeutic targets for drug repurposing against COVID-19. Results: We screened 1,584 high-confidence immune system proteins in ACE2 and TMPRSS2 co-expressing cells, finding 25 potential therapeutic targets significantly overexpressed in nasal goblet secretory cells, lung type II pneumocytes, and ileal absorptive enterocytes of patients with several immunopathologies. Then, we performed fully connected deep neural networks to find the best multitask classification model to predict the activity of 10,672 drugs, obtaining several approved drugs, compounds under investigation, and experimental compounds with the highest area under the receiver operating characteristics. Conclusion: After being effectively analyzed in clinical trials, these drugs can be considered for treatment of severe COVID-19 patients. Scripts can be downloaded at https://github.com/muntisa/immuno-drug-repurposing-COVID-19.", "doi": "10.3389/fphar.2021.598925", "pmid": "33716737", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "598925"}, {"db": "pmc", "key": "PMC7952300"}], "notes": [], "created": "2021-03-17T07:46:57.745Z", "modified": "2021-03-22T11:40:39.483Z"}, {"entity": "publication", "iuid": "42cbde64f28a462e8b59f47ad4eebf6d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/42cbde64f28a462e8b59f47ad4eebf6d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/42cbde64f28a462e8b59f47ad4eebf6d"}}, "title": "Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19: A Systematic Review and Meta-analysis.", "authors": [{"family": "Janiaud", "given": "Perrine", "initials": "P"}, {"family": "Axfors", "given": "Cathrine", "initials": "C"}, {"family": "Schmitt", "given": "Andreas M", "initials": "AM"}, {"family": "Gloy", "given": "Viktoria", "initials": "V"}, {"family": "Ebrahimi", "given": "Fahim", "initials": "F"}, {"family": "Hepprich", "given": "Matthias", "initials": "M"}, {"family": "Smith", "given": "Emily R", "initials": "ER"}, {"family": "Haber", "given": "Noah A", "initials": "NA"}, {"family": "Khanna", "given": "Nina", "initials": "N"}, {"family": "Moher", "given": "David", "initials": "D"}, {"family": "Goodman", "given": "Steven N", "initials": "SN"}, {"family": "Ioannidis", "given": "John P A", "initials": "JPA"}, {"family": "Hemkens", "given": "Lars G", "initials": "LG"}], "type": "journal article", "published": "2021-02-26", "journal": {"title": "JAMA", "issn": "1538-3598", "volume": null, "issue": null, "issn-l": "0098-7484"}, "abstract": "Convalescent plasma is a proposed treatment for COVID-19.\n\nTo assess clinical outcomes with convalescent plasma treatment vs placebo or standard of care in peer-reviewed and preprint publications or press releases of randomized clinical trials (RCTs).\n\nPubMed, the Cochrane COVID-19 trial registry, and the Living Overview of Evidence platform were searched until January 29, 2021.\n\nThe RCTs selected compared any type of convalescent plasma vs placebo or standard of care for patients with confirmed or suspected COVID-19 in any treatment setting.\n\nTwo reviewers independently extracted data on relevant clinical outcomes, trial characteristics, and patient characteristics and used the Cochrane Risk of Bias Assessment Tool. The primary analysis included peer-reviewed publications of RCTs only, whereas the secondary analysis included all publicly available RCT data (peer-reviewed publications, preprints, and press releases). Inverse variance-weighted meta-analyses were conducted to summarize the treatment effects. The certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation.\n\nAll-cause mortality, length of hospital stay, clinical improvement, clinical deterioration, mechanical ventilation use, and serious adverse events.\n\nA total of 1060 patients from 4 peer-reviewed RCTs and 10 722 patients from 6 other publicly available RCTs were included. The summary risk ratio (RR) for all-cause mortality with convalescent plasma in the 4 peer-reviewed RCTs was 0.93 (95% CI, 0.63 to 1.38), the absolute risk difference was -1.21% (95% CI, -5.29% to 2.88%), and there was low certainty of the evidence due to imprecision. Across all 10 RCTs, the summary RR was 1.02 (95% CI, 0.92 to 1.12) and there was moderate certainty of the evidence due to inclusion of unpublished data. Among the peer-reviewed RCTs, the summary hazard ratio was 1.17 (95% CI, 0.07 to 20.34) for length of hospital stay, the summary RR was 0.76 (95% CI, 0.20 to 2.87) for mechanical ventilation use (the absolute risk difference for mechanical ventilation use was -2.56% [95% CI, -13.16% to 8.05%]), and there was low certainty of the evidence due to imprecision for both outcomes. Limited data on clinical improvement, clinical deterioration, and serious adverse events showed no significant differences.\n\nTreatment with convalescent plasma compared with placebo or standard of care was not significantly associated with a decrease in all-cause mortality or with any benefit for other clinical outcomes. The certainty of the evidence was low to moderate for all-cause mortality and low for other outcomes.", "doi": "10.1001/jama.2021.2747", "pmid": "33635310", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "2777060"}], "notes": [], "created": "2021-03-01T10:31:35.067Z", "modified": "2021-03-01T10:31:35.077Z"}, {"entity": "publication", "iuid": "385673f5df3646bd8e3b61eeec8fda40", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/385673f5df3646bd8e3b61eeec8fda40.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/385673f5df3646bd8e3b61eeec8fda40"}}, "title": "Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19.", "authors": [{"family": "Gupta", "given": "Aakriti", "initials": "A"}, {"family": "Madhavan", "given": "Mahesh V", "initials": "MV"}, {"family": "Poterucha", "given": "Timothy J", "initials": "TJ"}, {"family": "DeFilippis", "given": "Ersilia M", "initials": "EM"}, {"family": "Hennessey", "given": "Jessica A", "initials": "JA"}, {"family": "Redfors", "given": "Bjorn", "initials": "B"}, {"family": "Eckhardt", "given": "Christina", "initials": "C"}, {"family": "Bikdeli", "given": "Behnood", "initials": "B"}, {"family": "Platt", "given": "Jonathan", "initials": "J"}, {"family": "Nalbandian", "given": "Ani", "initials": "A"}, {"family": "Elias", "given": "Pierre", "initials": "P"}, {"family": "Cummings", "given": "Matthew J", "initials": "MJ"}, {"family": "Nouri", "given": "Shayan N", "initials": "SN"}, {"family": "Lawlor", "given": "Matthew", "initials": "M"}, {"family": "Ranard", "given": "Lauren S", "initials": "LS"}, {"family": "Li", "given": "Jianhua", "initials": "J"}, {"family": "Boyle", "given": "Claudia", "initials": "C"}, {"family": "Givens", "given": "Raymond", "initials": "R"}, {"family": "Brodie", "given": "Daniel", "initials": "D"}, {"family": "Krumholz", "given": "Harlan M", "initials": "HM"}, {"family": "Stone", "given": "Gregg W", "initials": "GW"}, {"family": "Sethi", "given": "Sanjum S", "initials": "SS"}, {"family": "Burkhoff", "given": "Daniel", "initials": "D"}, {"family": "Uriel", "given": "Nir", "initials": "N"}, {"family": "Schwartz", "given": "Allan", "initials": "A"}, {"family": "Leon", "given": "Martin B", "initials": "MB"}, {"family": "Kirtane", "given": "Ajay J", "initials": "AJ"}, {"family": "Wan", "given": "Elaine Y", "initials": "EY"}, {"family": "Parikh", "given": "Sahil A", "initials": "SA"}], "type": "journal article", "published": "2021-02-26", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "1325", "issn-l": "2041-1723"}, "abstract": "The coronavirus disease 2019 (COVID-19) can result in a hyperinflammatory state, leading to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic complications, among other sequelae. Statins, which are known to have anti-inflammatory and antithrombotic properties, have been studied in the setting of other viral infections, but their benefit has not been assessed in COVID-19. This is a retrospective analysis of patients admitted with COVID-19 from February 1 st through May 12th, 2020 with study period ending on June 11th, 2020. Antecedent statin use was assessed using medication information available in the electronic medical record. We constructed a multivariable logistic regression model to predict the propensity of receiving statins, adjusting for baseline sociodemographic and clinical characteristics, and outpatient medications. The primary endpoint includes in-hospital mortality within 30 days. A total of 2626 patients were admitted during the study period, of whom 951 (36.2%) were antecedent statin users. Among 1296 patients (648 statin users, 648 non-statin users) identified with 1:1 propensity-score matching, statin use is significantly associated with lower odds of the primary endpoint in the propensity-matched cohort (OR 0.47, 95% CI 0.36-0.62, p < 0.001). We conclude that antecedent statin use in patients hospitalized with COVID-19 is associated with lower inpatient mortality.", "doi": "10.1038/s41467-021-21553-1", "pmid": "33637713", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-21553-1"}], "notes": [], "created": "2021-03-01T10:27:41.788Z", "modified": "2021-03-01T10:27:41.799Z"}, {"entity": "publication", "iuid": "83652c6eab6545dc856b7f96cab7fcbb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/83652c6eab6545dc856b7f96cab7fcbb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/83652c6eab6545dc856b7f96cab7fcbb"}}, "title": "A COVID-19 pandemic-specific, structured care process for Peritoneal Dialysis patients facilitated by Telemedicine: therapy continuity, prevention and complications management.", "authors": [{"family": "Polanco", "given": "Elianny", "initials": "E"}, {"family": "Aquey", "given": "Mercedes", "initials": "M"}, {"family": "Collado", "given": "Jhanna", "initials": "J"}, {"family": "Campos", "given": "Erwin", "initials": "E"}, {"family": "Guzman", "given": "Janny", "initials": "J"}, {"family": "Cuevas-Budhart", "given": "Miguel Angel", "initials": "MA"}, {"family": "Divino-Filho", "given": "Jos\u00e9 Carolino", "initials": "JC"}, {"family": "Ramos-Sanchez", "given": "Alfonso", "initials": "A"}], "type": "journal article", "published": "2021-02-26", "journal": {"title": "Ther Apher Dial", "issn": "1744-9987", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Coronavirus 2019 disease (COVID-19) has been declared a pandemia. Peritoneal dialysis (PD), being a home therapy, allows for physical distancing measures and movement restrictions. In order to prevent COVID-19 contagious among the Dominican Republic National Health System PD program patients, a follow up virtual protocol for this group was developed. The aim of this study is to outline the protocol established by the PD program's healthcare team using Telemedicine in order to avoid COVID-19 contagious and to report initial results and outcomes of this initiative.\r\n\r\nThis is an observational prospective longitudinal study with 946 patients being treated in seven centers distributed throughout the country between April 1 st and June 30th. The protocol was implemented focusing on the patient follow-up; risk mitigation data were registered and collected from electronic records.\r\n\r\nDuring the follow-up period, 95 catheters were implanted, 64 patients-initiated PD and the remaining were in training. A total of 9 532 consultations were given by the different team specialists, being 8 720 (91%) virtual and 812 (9%) face -to -face consultations. The transfer rate to HD was 0.29% whereas the peritonitis rate was 0.11 episode per patient/year. Eighteen adults tested positive for COVID-19.\r\n\r\nThe implementation of the protocol and Telemedicine utilization have ensured follow-up and monitoring, preserved therapy, controlled complications and PD lives protected. This article is protected by copyright. All rights reserved.", "doi": "10.1111/1744-9987.13635", "pmid": "33634948", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-03-01T10:32:43.595Z", "modified": "2021-06-18T14:28:10.323Z"}, {"entity": "publication", "iuid": "51fccdcf6a9d42be97470f6cd75694fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/51fccdcf6a9d42be97470f6cd75694fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/51fccdcf6a9d42be97470f6cd75694fc"}}, "title": "The fear of the COVID-19 Scale: validation in the Portuguese general population.", "authors": [{"family": "Soares", "given": "Francisca Ribeiro", "initials": "FR"}, {"family": "Afonso", "given": "Rosa Marina", "initials": "RM"}, {"family": "Martins", "given": "Ana Paula", "initials": "AP"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Rosa", "given": "Celina Pires", "initials": "CP"}], "type": "journal article", "published": "2021-02-25", "journal": {"title": "Death Stud", "issn": "1091-7683", "volume": null, "issue": null, "pages": "1-7", "issn-l": null}, "abstract": "The coronavirus disease (COVID-19) pandemic is having a profound effect on mental health and it is therefore fundamental to evaluate individual psychological responses to COVID-19. The 7-item Fear of COVID-19 Scale (FCV-19S) assesses different aspects of the fear of coronavirus and has been applied worldwide. This study aimed to translate and validate the FCV-19S in the Portuguese population. The scale was administered to a convenience sample of 1203 Portuguese adults. Exploratory factor analysis was carried out on the initial model proposed by the authors of the FCV-19S. Further analysis revealed that the Portuguese version has good psychometric properties.", "doi": "10.1080/07481187.2021.1889722", "pmid": "33630728", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-03-01T10:22:11.159Z", "modified": "2021-03-01T10:22:11.182Z"}, {"entity": "publication", "iuid": "0de3e14051a2404e9d8a3d49b564064c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0de3e14051a2404e9d8a3d49b564064c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0de3e14051a2404e9d8a3d49b564064c"}}, "title": "Long-term outcome after intensive care for COVID-19: differences between men and women-a nationwide cohort study.", "authors": [{"family": "Zettersten", "given": "Erik", "initials": "E"}, {"family": "Engerstr\u00f6m", "given": "Lars", "initials": "L"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "J\u00e4derling", "given": "Gabriella", "initials": "G"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}, {"family": "Block", "given": "Linda", "initials": "L"}, {"family": "Larsson", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2021-02-25", "journal": {"title": "Crit Care", "issn": "1466-609X", "volume": "25", "issue": "1", "pages": "86", "issn-l": "1364-8535"}, "abstract": "Questions remain about long-term outcome for COVID-19 patients in general, and differences between men and women in particular given the fact that men seem to suffer a more dramatic course of the disease. We therefore analysed outcome beyond 90 days in ICU patients with COVID-19, with special focus on differences between men and women.\n\nWe identified all patient \u2265 18 years with COVID-19 admitted between March 6 and June 30, 2020, in the Swedish Intensive Care Registry. Patients were followed until death or study end-point October 22, 2020. Association with patient sex and mortality, in addition to clinical variables, was estimated using Cox regression. We also performed a logistic regression model estimating factors associated with 90-day mortality.\n\nIn total, 2354 patients with COVID-19 were included. Four patients were still in the ICU at study end-point. Median follow-up time was 183 days. Mortality at 90-days was 26.9%, 23.4% in women and 28.2% in men. After 90 days until end of follow-up, only 11 deaths occurred. On multivariable Cox regression analysis, male sex (HR 1.28, 95% CI 1.06-1.54) remained significantly associated with mortality even after adjustments. Additionally, age, COPD/asthma, immune deficiency, malignancy, SAPS3 and admission month were associated with mortality. The logistic regression model of 90-day mortality showed almost identical results.\n\nIn this nationwide study of ICU patients with COVID-19, men were at higher risk of poor long-term outcome compared to their female counterparts. The underlying mechanisms for these differences are not fully understood and warrant further studies.", "doi": "10.1186/s13054-021-03511-x", "pmid": "33632273", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-021-03511-x"}, {"db": "pmc", "key": "PMC7906087"}], "notes": [], "created": "2021-03-09T06:31:12.788Z", "modified": "2021-03-09T06:33:30.216Z"}, {"entity": "publication", "iuid": "2850b672e81a4a34a39690a4cf8de736", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2850b672e81a4a34a39690a4cf8de736.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2850b672e81a4a34a39690a4cf8de736"}}, "title": "Genetic predisposition to psychiatric disorders and risk of COVID-19", "authors": [{"family": "Chen", "given": "Wenwen", "initials": "W"}, {"family": "Zeng", "given": "Yu", "initials": "Y"}, {"family": "Suo", "given": "Chen", "initials": "C"}, {"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Chen", "given": "Yilong", "initials": "Y"}, {"family": "Hou", "given": "Can", "initials": "C"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "Sun", "given": "Yajing", "initials": "Y"}, {"family": "Qu", "given": "Yuanyuan", "initials": "Y"}, {"family": "Lu", "given": "Donghao", "initials": "D"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "posted-content", "published": "2021-02-25", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.23.21251866", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-03-25T14:07:18.181Z", "modified": "2021-05-17T19:30:55.631Z"}, {"entity": "publication", "iuid": "0fab6b563c944cb3bc40603c2e02acad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0fab6b563c944cb3bc40603c2e02acad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0fab6b563c944cb3bc40603c2e02acad"}}, "title": "Beyond Chronological Age: Frailty and Multimorbidity Predict In-Hospital Mortality in Patients With Coronavirus Disease 2019.", "authors": [{"family": "Marengoni", "given": "Alessandra", "initials": "A"}, {"family": "Zucchelli", "given": "Alberto", "initials": "A", "orcid": "0000-0001-5992-8506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5ad05bd796f49c983931341109b1578.json"}}, {"family": "Vetrano", "given": "Davide Liborio", "initials": "DL", "orcid": "0000-0002-3099-4830", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0124721bb214413a34c965b6accc64b.json"}}, {"family": "Armellini", "given": "Andrea", "initials": "A"}, {"family": "Botteri", "given": "Emanuele", "initials": "E"}, {"family": "Nicosia", "given": "Franco", "initials": "F"}, {"family": "Romanelli", "given": "Giuseppe", "initials": "G"}, {"family": "Beindorf", "given": "Eva Andrea", "initials": "EA"}, {"family": "Giansiracusa", "given": "Paola", "initials": "P"}, {"family": "Garrafa", "given": "Emirena", "initials": "E"}, {"family": "Ferrucci", "given": "Luigi", "initials": "L", "orcid": "0000-0002-6273-1613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2edec69f580a4daea9ee99fa666c8f53.json"}}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Bernabei", "given": "Roberto", "initials": "R"}, {"family": "Onder", "given": "Graziano", "initials": "G"}], "type": "journal article", "published": "2021-02-25", "journal": {"title": "J Gerontol A Biol Sci Med Sci", "issn": "1758-535X", "issn-l": "1079-5006", "volume": "76", "issue": "3", "pages": "e38-e45"}, "abstract": "We evaluated whether frailty and multimorbidity predict in-hospital mortality in patients with COVID-19 beyond chronological age.\n\nA total of 165 patients admitted from March 8th to April 17th, 2020, with COVID-19 in an acute geriatric ward in Italy were included. Predisease frailty was assessed with the Clinical Frailty Scale (CFS). Multimorbidity was defined as the co-occurrence of \u22652 diseases in the same patient. The hazard ratio (HR) of in-hospital mortality as a function of CFS score and number of chronic diseases in the whole population and in those aged 70+ years were calculated.\n\nAmong the 165 patients, 112 were discharged, 11 were transferred to intensive care units, and 42 died. Patients who died were older (81.0 vs 65.2 years, p < .001), more frequently multimorbid (97.6 vs 52.8%; p < .001), and more likely frail (37.5 vs 4.1%; p < .001). Less than 2.0% of patients without multimorbidity and frailty, 28% of those with multimorbidity only, and 75% of those with both multimorbidity and frailty died. Each unitary increment in the CFS was associated with a higher risk of in-hospital death in the whole sample (HR = 1.3; 95% CI = 1.05-1.62) and in patients aged 70+ years (HR = 1.29; 95% CI = 1.04-1.62), whereas the number of chronic diseases was not significantly associated with higher risk of death. The CFS addition to age and sex increased mortality prediction by 9.4% in those aged 70+ years.\n\nFrailty identifies patients with COVID-19 at risk of in-hospital death independently of age. Multimorbidity contributes to prognosis because of the very low probability of death in its absence.", "doi": "10.1093/gerona/glaa291", "pmid": "33216846", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7717138"}, {"db": "pii", "key": "5996087"}], "notes": [], "created": "2020-11-26T14:33:41.983Z", "modified": "2023-06-19T15:29:21.072Z"}, {"entity": "publication", "iuid": "9c0721ae5def464c81523f9e3565392e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9c0721ae5def464c81523f9e3565392e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9c0721ae5def464c81523f9e3565392e"}}, "title": "A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.", "authors": [{"family": "Zhou", "given": "Sirui", "initials": "S"}, {"family": "Butler-Laporte", "given": "Guillaume", "initials": "G"}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T"}, {"family": "Morrison", "given": "David R", "initials": "DR"}, {"family": "Afilalo", "given": "Jonathan", "initials": "J"}, {"family": "Afilalo", "given": "Marc", "initials": "M"}, {"family": "Laurent", "given": "Laetitia", "initials": "L"}, {"family": "Pietzner", "given": "Maik", "initials": "M"}, {"family": "Kerrison", "given": "Nicola", "initials": "N"}, {"family": "Zhao", "given": "Kaiqiong", "initials": "K"}, {"family": "Brunet-Ratnasingham", "given": "Elsa", "initials": "E"}, {"family": "Henry", "given": "Danielle", "initials": "D"}, {"family": "Kimchi", "given": "Nofar", "initials": "N"}, {"family": "Afrasiabi", "given": "Zaman", "initials": "Z"}, {"family": "Rezk", "given": "Nardin", "initials": "N"}, {"family": "Bouab", "given": "Meriem", "initials": "M"}, {"family": "Petitjean", "given": "Louis", "initials": "L"}, {"family": "Guzman", "given": "Charlotte", "initials": "C"}, {"family": "Xue", "given": "Xiaoqing", "initials": "X"}, {"family": "Tselios", "given": "Chris", "initials": "C"}, {"family": "Vulesevic", "given": "Branka", "initials": "B"}, {"family": "Adeleye", "given": "Olumide", "initials": "O"}, {"family": "Abdullah", "given": "Tala", "initials": "T"}, {"family": "Almamlouk", "given": "Noor", "initials": "N"}, {"family": "Chen", "given": "Yiheng", "initials": "Y"}, {"family": "Chass\u00e9", "given": "Micha\u00ebl", "initials": "M"}, {"family": "Durand", "given": "Madeleine", "initials": "M"}, {"family": "Paterson", "given": "Clare", "initials": "C"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Greenwood", "given": "Celia M T", "initials": "CMT"}, {"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "Langenberg", "given": "Claudia", "initials": "C"}, {"family": "Thysell", "given": "Elin", "initials": "E"}, {"family": "Pollak", "given": "Michael", "initials": "M"}, {"family": "Mooser", "given": "Vincent", "initials": "V"}, {"family": "Forgetta", "given": "Vincenzo", "initials": "V"}, {"family": "Kaufmann", "given": "Daniel E", "initials": "DE"}, {"family": "Richards", "given": "J Brent", "initials": "JB"}], "type": "journal article", "published": "2021-02-25", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956", "volume": "27", "issue": "4", "pages": "659-667"}, "abstract": "To identify circulating proteins influencing Coronavirus Disease 2019 (COVID-19) susceptibility and severity, we undertook a two-sample Mendelian randomization (MR) study, rapidly scanning hundreds of circulating proteins while reducing bias due to reverse causation and confounding. In up to 14,134 cases and 1.2 million controls, we found that an s.d. increase in OAS1 levels was associated with reduced COVID-19 death or ventilation (odds ratio (OR) = 0.54, P = 7 \u00d7 10 -8), hospitalization (OR = 0.61, P = 8 \u00d7 10-8) and susceptibility (OR = 0.78, P = 8 \u00d7 10-6). Measuring OAS1 levels in 504 individuals, we found that higher plasma OAS1 levels in a non-infectious state were associated with reduced COVID-19 susceptibility and severity. Further analyses suggested that a Neanderthal isoform of OAS1 in individuals of European ancestry affords this protection. Thus, evidence from MR and a case-control study support a protective role for OAS1 in COVID-19 adverse outcomes. Available pharmacological agents that increase OAS1 levels could be prioritized for drug development.", "doi": "10.1038/s41591-021-01281-1", "pmid": "33633408", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-021-01281-1"}], "notes": [], "created": "2021-03-01T10:33:22.847Z", "modified": "2021-05-27T16:07:53.701Z"}, {"entity": "publication", "iuid": "27dbd4e1c95d41ada0ae228dda5eda93", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27dbd4e1c95d41ada0ae228dda5eda93.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27dbd4e1c95d41ada0ae228dda5eda93"}}, "title": "Ophthalmic Screening in Patients with Coronavirus Disease 2019: A Prospective Cohort Study.", "authors": [{"family": "Papazoglou", "given": "Anthia", "initials": "A"}, {"family": "Conen", "given": "Anna", "initials": "A"}, {"family": "Haubitz", "given": "Sebastian", "initials": "S"}, {"family": "Tschopp", "given": "Markus", "initials": "M"}, {"family": "Guignard", "given": "Viviane J", "initials": "VJ"}, {"family": "Menke", "given": "Marcel N", "initials": "MN"}, {"family": "Enz", "given": "Tim J", "initials": "TJ"}], "type": "journal article", "published": "2021-02-24", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "10", "issue": "5", "pages": null}, "abstract": "Postmortem pathological examinations, animal studies, and anecdotal reports suggest that coronavirus disease 2019 (COVID-19) could potentially affect intraocular tissue. However, published evidence is scarce and conflicting. In our study, we screened 100 eyes of 50 patients hospitalized for COVID-19. Relevant medical and ophthalmological history was assessed as well as symptoms, laboratory results, specific treatments, clinical course, and outcome. Ophthalmic exams including assessment of best corrected visual acuity (BCVA), intraocular pressure (IOP), color perception, ocular motility, ophthalmoscopy as well as optical coherence tomography (OCT) of the macula and the optic disc was performed at hospital admission and 29 to 192 days later. Of the 50 patients included, 14 (28%) were female. Median age was 64.5 (range 29-90) years. COVID-19 severity was mild in 15 (30%), severe in 30 (60%), and critical in five cases (10%). At baseline, median BCVA was 0.1 (0-1.8) Logarithm of the Minimum Angle of Resolution (LogMAR) and median IOP was 16 (8-22) mmHg. At follow-up, no relevant changes in BCVA and IOP were documented. No signs of active intraocular inflammation or optic nerve affection were found and OCT findings were widely stable during the observation period. Our findings suggest that COVID-19 does not regularly affect intraocular tissue.", "doi": "10.3390/jcm10050896", "pmid": "33668256", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "jcm10050896"}, {"db": "URL", "key": "https://www.mdpi.com/2077-0383/10/5/896/s1", "description": "Patient characteristics, medical treatment regiments, symptoms, laboratory findings, ophthalmic findings, systemic symtoms for each patient"}], "notes": [], "created": "2021-03-08T05:28:12.245Z", "modified": "2021-06-18T12:52:19.368Z"}, {"entity": "publication", "iuid": "f3681b42d7da4392816918aab5db8ce7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f3681b42d7da4392816918aab5db8ce7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f3681b42d7da4392816918aab5db8ce7"}}, "title": "Multisystem inflammatory syndrome in children and adults (MIS-C/A): Case definition & guidelines for data collection, analysis, and presentation of immunization safety data.", "authors": [{"family": "Vogel", "given": "Tiphanie P", "initials": "TP"}, {"family": "Top", "given": "Karina A", "initials": "KA"}, {"family": "Karatzios", "given": "Christos", "initials": "C"}, {"family": "Hilmers", "given": "David C", "initials": "DC"}, {"family": "Tapia", "given": "Lorena I", "initials": "LI"}, {"family": "Moceri", "given": "Pamela", "initials": "P"}, {"family": "Giovannini-Chami", "given": "Lisa", "initials": "L"}, {"family": "Wood", "given": "Nicholas", "initials": "N"}, {"family": "Chandler", "given": "Rebecca E", "initials": "RE"}, {"family": "Klein", "given": "Nicola P", "initials": "NP"}, {"family": "Schlaudecker", "given": "Elizabeth P", "initials": "EP"}, {"family": "Poli", "given": "M Cecilia", "initials": "MC"}, {"family": "Muscal", "given": "Eyal", "initials": "E"}, {"family": "Munoz", "given": "Flor M", "initials": "FM"}], "type": "journal article", "published": "2021-02-24", "journal": {"title": "Vaccine", "issn": "1873-2518", "volume": null, "issue": null, "issn-l": null}, "abstract": "This is a Brighton Collaboration Case Definition of the term \"Multisystem Inflammatory Syndrome in Children and Adults (MIS-C/A)\" to be utilized in the evaluation of adverse events following immunization. The case definition was developed by topic experts convened by the Coalition for Epidemic Preparedness Innovations (CEPI) in the context of active development of vaccines for SARS-CoV-2. The format of the Brighton Collaboration was followed, including an exhaustive review of the literature, to develop a consensus definition and defined levels of certainty. The document underwent peer review by the Brighton Collaboration Network and by selected expert external reviewers prior to submission. The comments of the reviewers were taken into consideration and edits incorporated into this final manuscript.", "doi": "10.1016/j.vaccine.2021.01.054", "pmid": "33640145", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(21)00093-1"}], "notes": [], "created": "2021-03-01T10:25:43.038Z", "modified": "2021-03-01T10:25:43.048Z"}, {"entity": "publication", "iuid": "66da60a87f714d26af9d07d6218d0f85", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66da60a87f714d26af9d07d6218d0f85.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66da60a87f714d26af9d07d6218d0f85"}}, "title": "Impact of winter holiday and government responses on mortality in Europe during the first wave of the COVID-19 pandemic.", "authors": [{"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}, {"family": "Mattisson", "given": "Kristoffer", "initials": "K"}, {"family": "Ahlbom", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-02-24", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": null, "issue": null, "pages": null}, "abstract": "This aggregated population study investigated the impact of the seemingly quasi-randomly assigned school winter holiday in week 6-10 (February to early March) on excess mortality in 219 European regions (11 countries) during the COVID-19 pandemic in the spring 2020. A secondary aim was to evaluate the impact of government responses to the early inflow of infected cases.\r\n\r\nData on government responses week 8-14 were obtained from the Oxford COVID-19 Government Response Tracker. Regional data on total all-cause mortality during week 14-23 in 2020 were retrieved from Eurostat and national statistical agencies and compared with the average mortality during same period 2015-2019. Variance-weighted least square regression was used with mortality difference as dependent variable with adjustment for country, population density and age distribution.\r\n\r\nBeing a region with winter holiday exclusively in week 9 was in the adjusted analysis associated with 16 weekly excess deaths (95% confidence interval 13 to 20) per million inhabitants during week 14-23, which corresponds to 38% of the excess mortality in these regions. A more stringent response implemented in week 11, corresponding to 10 additional units on the 0-100 ordinal scale, was associated with 20 fewer weekly deaths (95% confidence interval 18 to 22) per million inhabitants.\r\n\r\nWinter holiday in week 9 was an amplifying event that contributed importantly to the excess mortality observed in the study regions during the spring 2020. Timely government responses to the resulting early inflow of cases reduced the excess in mortality.", "doi": "10.1093/eurpub/ckab017", "pmid": "33624821", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6149087"}], "notes": [], "created": "2021-02-25T10:12:25.738Z", "modified": "2021-06-18T14:24:11.844Z"}, {"entity": "publication", "iuid": "24a65e888eac4b9e8306546e341d401c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24a65e888eac4b9e8306546e341d401c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24a65e888eac4b9e8306546e341d401c"}}, "title": "COVID-19 drug practices risk antimicrobial resistance evolution.", "authors": [{"family": "Afshinnekoo", "given": "Ebrahim", "initials": "E"}, {"family": "Bhattacharya", "given": "Chandrima", "initials": "C"}, {"family": "Burguete-Garc\u00eda", "given": "Ana", "initials": "A"}, {"family": "Castro-Nallar", "given": "Eduardo", "initials": "E"}, {"family": "Deng", "given": "Youping", "initials": "Y"}, {"family": "Desnues", "given": "Christelle", "initials": "C"}, {"family": "Dias-Neto", "given": "Emmanuel", "initials": "E"}, {"family": "Elhaik", "given": "Eran", "initials": "E"}, {"family": "Iraola", "given": "Gregorio", "initials": "G"}, {"family": "Jang", "given": "Soojin", "initials": "S"}, {"family": "\u0141abaj", "given": "Pawe\u0142 P", "initials": "PP"}, {"family": "Mason", "given": "Christopher E", "initials": "CE"}, {"family": "Nagarajan", "given": "Niranjan", "initials": "N"}, {"family": "Poulsen", "given": "Michael", "initials": "M"}, {"family": "Prithiviraj", "given": "Bharath", "initials": "B"}, {"family": "Siam", "given": "Rania", "initials": "R"}, {"family": "Shi", "given": "Tieliu", "initials": "T"}, {"family": "Suzuki", "given": "Haruo", "initials": "H"}, {"family": "Werner", "given": "Johannes", "initials": "J"}, {"family": "Zambrano", "given": "Maria Mercedes", "initials": "MM"}, {"family": "Bhattacharyya", "given": "Malay", "initials": "M"}, {"family": "MetaSUB Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2021-02-24", "journal": {"title": "The Lancet Microbe", "issn": "2666-5247", "volume": null, "issue": null, "issn-l": "2666-5247"}, "abstract": null, "doi": "10.1016/S2666-5247(21)00039-2", "pmid": "33655229", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2666-5247(21)00039-2"}, {"db": "pmc", "key": "PMC7906697"}], "notes": [], "created": "2021-03-04T15:02:32.660Z", "modified": "2021-03-04T15:03:01.727Z"}, {"entity": "publication", "iuid": "70eb4ec5d8b546539a46419b7a79a095", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70eb4ec5d8b546539a46419b7a79a095.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70eb4ec5d8b546539a46419b7a79a095"}}, "title": "Mental health among elite athletes in Norway during a selected period of the COVID-19 pandemic.", "authors": [{"family": "Pensgaard", "given": "Anne Marte", "initials": "AM", "orcid": "0000-0003-4690-9888", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec779958709e4ca18ff8fdf000d55075.json"}}, {"family": "Oevreboe", "given": "Tom Henning", "initials": "TH", "orcid": "0000-0003-4965-1018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee49f62a86ee4e97a5cc820570933f27.json"}}, {"family": "Ivarsson", "given": "Andreas", "initials": "A", "orcid": "0000-0002-8987-5975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e77e48568e184548a5da063cb6b339be.json"}}], "type": "journal article", "published": "2021-02-23", "journal": {"title": "BMJ Open Sport Exerc Med", "issn": "2055-7647", "volume": "7", "issue": "1", "pages": "e001025", "issn-l": null}, "abstract": "To investigate the prevalence of mental health problems and satisfaction with life among different groups of elite athletes during a selected period of the COVID-19 pandemic and examine how COVID-19 related consequences were associated with these variables.\n\nCross-sectional data collection during a selected period of the COVID-19 pandemic in Norway.\n\n378 elite athletes, mean age 26.86 (range 18-59), 159 females and 219 males, divided into Olympic-level and Paralympic-level athletes (n=194) and elite and semielite athletes (n=184).\n\nHopkins Symptoms Check List - 10; symptoms of anxiety and depression; Bergen Insomnia Scale; Eating Disorder Examination Questionnaire Short; Canadian Problem Gambling Index and Satisfaction with Life Scale. In addition, we included specific COVID-19 questions (eg, financial concern, keeping daily routines, perceived coping and motivation).\n\nSymptoms of insomnia (38.3%) and depression (22.3%) were most prevalent within the sample. Symptoms of eating disorders more prevalent among female athletes (8.8% vs 1.4%) while symptoms of gambling problems were higher among male athletes (8.6% vs 1.3%). Olympic and Paralympic athletes reported lower levels of anxiety and depression symptoms than elite and semielite athletes. Financial concerns were associated with an increased risk of mental health problems, while daily routines and perception of coping were associated with less mental health problems and higher satisfaction with life.\n\nSymptoms of insomnia and depression were the two most common mental health problems reported during this selected phase of the COVID-19 pandemic. Elite and semielite athletes reported financial concerns as a risk factor for mental health problems at a larger degree than Olympic and Paralympic athletes.", "doi": "10.1136/bmjsem-2020-001025", "pmid": "34192011", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjsem-2020-001025"}, {"db": "pmc", "key": "PMC7907612"}], "notes": [], "created": "2021-07-05T14:26:16.214Z", "modified": "2021-07-05T15:08:54.718Z"}, {"entity": "publication", "iuid": "90f48cf5d5dd4a08b86cc84031aec1c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90f48cf5d5dd4a08b86cc84031aec1c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90f48cf5d5dd4a08b86cc84031aec1c9"}}, "title": "Impact of the COVID-19 pandemic on morbidity and mortality in patients with inflammatory joint diseases and in the general population: a nationwide Swedish cohort study.", "authors": [{"family": "Bower", "given": "Hannah", "initials": "H"}, {"family": "Frisell", "given": "Thomas", "initials": "T"}, {"family": "Di Giuseppe", "given": "Daniela", "initials": "D"}, {"family": "Delcoigne", "given": "B\u00e9n\u00e9dicte", "initials": "B"}, {"family": "Ahlenius", "given": "Gerd-Marie", "initials": "G"}, {"family": "Baecklund", "given": "Eva", "initials": "E"}, {"family": "Chatzidionysiou", "given": "Katerina", "initials": "K"}, {"family": "Feltelius", "given": "Nils", "initials": "N"}, {"family": "Forsblad-d'Elia", "given": "Helena", "initials": "H"}, {"family": "Kastbom", "given": "Alf", "initials": "A"}, {"family": "Klareskog", "given": "Lars", "initials": "L"}, {"family": "Lindqvist", "given": "Elisabet", "initials": "E"}, {"family": "Lindstr\u00f6m", "given": "Ulf", "initials": "U"}, {"family": "Turesson", "given": "Carl", "initials": "C"}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C"}, {"family": "Askling", "given": "Johan", "initials": "J"}, {"family": "ARTIS Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-02-23", "journal": {"title": "Ann Rheum Dis", "issn": "1468-2060", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To estimate absolute and relative risks for all-cause mortality and for severe COVID-19 in inflammatory joint diseases (IJDs) and with antirheumatic therapies.\r\n\r\nThrough Swedish nationwide multiregister linkages, we selected all adult patients with rheumatoid arthritis (RA, n=53 455 in March 2020), other IJDs (here: spondyloarthropathies, psoriatic arthritis and juvenile idiopathic arthritis, n=57 112), their antirheumatic drug use, and individually matched population referents. We compared annual all-cause mortality March-September 2015 through 2020 within and across cohorts, and assessed absolute and relative risks for hospitalisation, admission to intensive care and death due to COVID-19 March-September 2020, using Cox regression.\r\n\r\nDuring March-September 2020, the absolute all-cause mortality in RA and in other IJDs was higher than 2015-2019, but relative risks versus the general population (around 2 and 1.5) remained similar during 2020 compared with 2015-2019. Among patients with IJD, the risks of hospitalisation (0.5% vs 0.3% in their population referents), admission to intensive care (0.04% vs 0.03%) and death (0.10% vs 0.07%) due to COVID-19 were low. Antirheumatic drugs were not associated with increased risk of serious COVID-19 outcomes, although for certain drugs, precision was limited.\r\n\r\nRisks of severe COVID-19-related outcomes were increased among patients with IJDs, but risk increases were also seen for non-COVID-19 morbidity. Overall absolute and excess risks are low and the level of risk increases are largely proportionate to those in the general population, and explained by comorbidities. With possible exceptions, antirheumatic drugs do not have a major impact on these risks.", "doi": "10.1136/annrheumdis-2021-219845", "pmid": "33622688", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "annrheumdis-2021-219845"}], "notes": [], "created": "2021-02-25T12:30:45.045Z", "modified": "2021-06-18T14:23:09.973Z"}, {"entity": "publication", "iuid": "1587f1507ee34fd9ba0ae982cdb57e9a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1587f1507ee34fd9ba0ae982cdb57e9a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1587f1507ee34fd9ba0ae982cdb57e9a"}}, "title": "Critical COVID-19 represents an endothelial disease with high similarity to kidney disease on the molecular level", "authors": [{"family": "Siwy", "given": "Justyna", "initials": "J"}, {"family": "Wendt", "given": "Ralph", "initials": "R"}, {"family": "Albalat", "given": "Amaya", "initials": "A"}, {"family": "He", "given": "Tianlin", "initials": "T"}, {"family": "Mischak", "given": "Harald", "initials": "H"}, {"family": "Mullen", "given": "William", "initials": "W"}, {"family": "Latosinska", "given": "Agnieszka", "initials": "A"}, {"family": "Luebbert", "given": "Christoph", "initials": "C"}, {"family": "Kalbitz", "given": "Sven", "initials": "S"}, {"family": "Mebazaa", "given": "Alexandre", "initials": "A"}, {"family": "Peters", "given": "Bjoern", "initials": "B"}, {"family": "Stegmayr", "given": "Bernd", "initials": "B"}, {"family": "Spasovski", "given": "Goce", "initials": "G"}, {"family": "Wiech", "given": "Thorsten", "initials": "T"}, {"family": "Staessen", "given": "Jan", "initials": "J"}, {"family": "Wolf", "given": "Johannes", "initials": "J"}, {"family": "Beige", "given": "Joachim", "initials": "J"}], "type": "posted-content", "published": "2021-02-23", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.22.21252207", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-24T06:19:47.773Z", "modified": "2021-02-26T08:45:47.876Z"}, {"entity": "publication", "iuid": "3a3d1d8fbf594a02997f31c228efb07e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a3d1d8fbf594a02997f31c228efb07e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a3d1d8fbf594a02997f31c228efb07e"}}, "title": "Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients.", "authors": [{"family": "Zhao", "given": "Yu", "initials": "Y"}, {"family": "Kilian", "given": "Christoph", "initials": "C"}, {"family": "Turner", "given": "Jan-Eric", "initials": "JE"}, {"family": "Bosurgi", "given": "Lidia", "initials": "L"}, {"family": "Roedl", "given": "Kevin", "initials": "K"}, {"family": "Bartsch", "given": "Patricia", "initials": "P"}, {"family": "Gnirck", "given": "Ann-Christin", "initials": "AC"}, {"family": "Cortesi", "given": "Filippo", "initials": "F"}, {"family": "Schulthei\u00df", "given": "Christoph", "initials": "C"}, {"family": "Hellmig", "given": "Malte", "initials": "M"}, {"family": "Enk", "given": "Leon U B", "initials": "LUB"}, {"family": "Hausmann", "given": "Fabian", "initials": "F"}, {"family": "Borchers", "given": "Alina", "initials": "A"}, {"family": "Wong", "given": "Milagros N", "initials": "MN"}, {"family": "Paust", "given": "Hans-Joachim", "initials": "HJ"}, {"family": "Siracusa", "given": "Francesco", "initials": "F"}, {"family": "Scheibel", "given": "Nicola", "initials": "N"}, {"family": "Herrmann", "given": "Marissa", "initials": "M"}, {"family": "Rosati", "given": "Elisa", "initials": "E"}, {"family": "Bacher", "given": "Petra", "initials": "P"}, {"family": "Kylies", "given": "Dominik", "initials": "D"}, {"family": "Jarczak", "given": "Dominik", "initials": "D"}, {"family": "L\u00fctgehetmann", "given": "Marc", "initials": "M"}, {"family": "Pfefferle", "given": "Susanne", "initials": "S"}, {"family": "Steurer", "given": "Stefan", "initials": "S"}, {"family": "Zur-Wiesch", "given": "Julian Schulze", "initials": "JS"}, {"family": "Puelles", "given": "Victor G", "initials": "VG"}, {"family": "Sperhake", "given": "Jan-Peter", "initials": "JP"}, {"family": "Addo", "given": "Marylyn M", "initials": "MM"}, {"family": "Lohse", "given": "Ansgar W", "initials": "AW"}, {"family": "Binder", "given": "Mascha", "initials": "M"}, {"family": "Huber", "given": "Samuel", "initials": "S"}, {"family": "Huber", "given": "Tobias B", "initials": "TB"}, {"family": "Kluge", "given": "Stefan", "initials": "S"}, {"family": "Bonn", "given": "Stefan", "initials": "S"}, {"family": "Panzer", "given": "Ulf", "initials": "U"}, {"family": "Gagliani", "given": "Nicola", "initials": "N"}, {"family": "Krebs", "given": "Christian F", "initials": "CF"}], "type": "journal article", "published": "2021-02-23", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "volume": "6", "issue": "56", "issn-l": "2470-9468"}, "abstract": "Hyperinflammation contributes to lung injury and subsequent acute respiratory distress syndrome (ARDS) with high mortality in patients with severe coronavirus disease 2019 (COVID-19). To understand the underlying mechanisms involved in lung pathology, we investigated the role of the lung-specific immune response. We profiled immune cells in bronchoalveolar lavage fluid and blood collected from COVID-19 patients with severe disease and bacterial pneumonia patients not associated with viral infection. By tracking T cell clones across tissues, we identified clonally expanded tissue-resident memory-like Th17 cells (Trm17 cells) in the lungs even after viral clearance. These Trm17 cells were characterized by a a potentially pathogenic cytokine expression profile of IL17A and CSF2 (GM-CSF). Interactome analysis suggests that Trm17 cells can interact with lung macrophages and cytotoxic CD8+ T cells, which have been associated with disease severity and lung damage. High IL-17A and GM-CSF protein levels in the serum of COVID-19 patients were associated with a more severe clinical course. Collectively, our study suggests that pulmonary Trm17 cells are one potential orchestrator of the hyperinflammation in severe COVID-19.", "doi": "10.1126/sciimmunol.abf6692", "pmid": "33622974", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6/56/eabf6692"}], "notes": [], "created": "2021-02-25T12:27:16.311Z", "modified": "2021-02-26T08:45:48.060Z"}, {"entity": "publication", "iuid": "1b7f181e2f4d46e098cde3f9ce275f58", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b7f181e2f4d46e098cde3f9ce275f58.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b7f181e2f4d46e098cde3f9ce275f58"}}, "title": "The Outcome of Critically Ill COVID-19 Patients Is Linked to Thromboinflammation Dominated by the Kallikrein/Kinin System.", "authors": [{"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Persson", "given": "Barbro", "initials": "B"}, {"family": "Eriksson", "given": "Oskar", "initials": "O"}, {"family": "Blom", "given": "Anna M", "initials": "AM"}, {"family": "Fromell", "given": "Karin", "initials": "K"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Huber-Lang", "given": "Markus", "initials": "M"}, {"family": "Ekdahl", "given": "Kristina N", "initials": "KN"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Nilsson", "given": "Bo", "initials": "B"}], "type": "journal article", "published": "2021-02-22", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "12", "issue": null, "pages": "627579"}, "abstract": "An important manifestation of severe COVID-19 is the ARDS-like lung injury that is associated with vascular endothelialitis, thrombosis, and angiogenesis. The intravascular innate immune system (IIIS), including the complement, contact, coagulation, and fibrinolysis systems, which is crucial for recognizing and eliminating microorganisms and debris in the body, is likely to be involved in the pathogenesis of COVID-19 ARDS. Biomarkers for IIIS activation were studied in the first 66 patients with COVID-19 admitted to the ICU in Uppsala University Hospital, both cross-sectionally on day 1 and in 19 patients longitudinally for up to a month, in a prospective study. IIIS analyses were compared with biochemical parameters and clinical outcome and survival. Blood cascade systems activation leading to an overreactive conjunct thromboinflammation was demonstrated, reflected in consumption of individual cascade system components, e.g., FXII, prekallikrein, and high molecular weight kininogen and in increased levels of activation products, e.g., C4d, C3a, C3d,g, sC5b-9, TAT, and D-dimer. Strong associations were found between the blood cascade systems and organ damage, illness severity scores, and survival. We show that critically ill COVID-19 patients display a conjunct activation of the IIIS that is linked to organ damage of the lung, heart, kidneys, and death. We present evidence that the complement and in particular the kallikrein/kinin system is strongly activated and that both systems are prognostic markers of the outcome of the patients suggesting their role in driving the inflammation. Already licensed kallikrein/kinin inhibitors are potential drugs for treatment of critically ill patients with COVID-19.", "doi": "10.3389/fimmu.2021.627579", "pmid": "33692801", "labels": {"Funder: VR": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pmc", "key": "PMC7937878"}], "notes": [], "created": "2021-03-12T06:30:27.350Z", "modified": "2022-02-14T15:59:07.466Z"}, {"entity": "publication", "iuid": "59c5edd4606e4ff6b9b1f5c02df9ffb5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/59c5edd4606e4ff6b9b1f5c02df9ffb5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/59c5edd4606e4ff6b9b1f5c02df9ffb5"}}, "title": "Indirect Immunofluorescence for Detecting Anti-Neuronal Autoimmunity in CSF after COVID-19 - Possibilities and Pitfalls.", "authors": [{"family": "Mulder", "given": "Jan", "initials": "J"}, {"family": "Lindqvist", "given": "Isa", "initials": "I"}, {"family": "Rasmusson", "given": "Annica J", "initials": "AJ"}, {"family": "Hus\u00e9n", "given": "Evelina", "initials": "E"}, {"family": "R\u00f6nnelid", "given": "Johan", "initials": "J"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "Cunningham", "given": "Janet L", "initials": "JL"}], "type": "letter", "published": "2021-02-22", "journal": {"title": "Brain Behav Immun", "issn": "1090-2139", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/j.bbi.2021.02.013", "pmid": "33631284", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S0889-1591(21)00078-7"}], "notes": [], "created": "2021-03-01T10:24:42.657Z", "modified": "2021-03-01T10:25:01.801Z"}, {"entity": "publication", "iuid": "463bf10b1aa84edb89f6a8d116341e93", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/463bf10b1aa84edb89f6a8d116341e93.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/463bf10b1aa84edb89f6a8d116341e93"}}, "title": "Frailty and comorbidity in predicting community COVID \u201019 mortality in the UK Biobank: the effect of sampling", "authors": [{"family": "Mak", "given": "Jonathan K L", "initials": "JKL"}, {"family": "Kuja\u2010Halkola", "given": "Ralf", "initials": "R"}, {"family": "Wang", "given": "Yunzhang", "initials": "Y"}, {"family": "H\u00e4gg", "given": "Sara", "initials": "S"}, {"family": "Jylh\u00e4v\u00e4", "given": "Juulia", "initials": "J"}], "type": "journal-article", "published": "2021-02-22", "journal": {"title": "J Am Geriatr Soc", "issn": "0002-8614", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1111/jgs.17089", "pmid": null, "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-24T06:15:15.735Z", "modified": "2021-06-18T14:21:14.474Z"}, {"entity": "publication", "iuid": "f7f307cb36194462b403a98c216e3d2f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7f307cb36194462b403a98c216e3d2f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7f307cb36194462b403a98c216e3d2f"}}, "title": "Digitalizing a Brief Intervention to Reduce Intrusive Memories of Psychological Trauma: Qualitative Interview Study", "authors": [{"family": "Gamble", "given": "Beau", "initials": "B"}, {"family": "Depa", "given": "Katherine", "initials": "K"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}, {"family": "Kanstrup", "given": "Marie", "initials": "M"}], "type": "journal-article", "published": "2021-02-22", "journal": {"title": "JMIR Ment Health", "issn": "2368-7959", "volume": "8", "issue": "2", "pages": "e23712", "issn-l": null}, "abstract": null, "doi": "10.2196/23712", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-23T07:12:28.728Z", "modified": "2021-02-26T08:47:00.316Z"}, {"entity": "publication", "iuid": "ebceb4aab75b41cf84f88db076202122", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ebceb4aab75b41cf84f88db076202122.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ebceb4aab75b41cf84f88db076202122"}}, "title": "COVID-19, Religious Coping, and Weight Change in the Orthodox Jewish Community.", "authors": [{"family": "Pirutinsky", "given": "Steven", "initials": "S"}, {"family": "Cherniak", "given": "Aaron D", "initials": "AD"}, {"family": "Rosmarin", "given": "David H", "initials": "DH"}], "type": "journal article", "published": "2021-02-21", "journal": {"title": "J Relig Health", "issn": "1573-6571", "volume": null, "issue": null, "issn-l": null}, "abstract": "Given links between stress and obesity, it is likely that individuals gained weight during the COVID-19 lockdown. Research suggests that religiosity facilitates coping, which may have lessened the relationship between stress and weight gain during the COVID-19 lockdown. We examined this relationship among Orthodox Jews (n = 731). Results indicated that stress was marginally associated with weight gain, and that this was moderated by intrinsic religiosity (IR). For those with low IR, stress correlated with weight gain, while for those with mean or higher IR, stress and weight change were unrelated. Results suggest that for some, religiosity may moderate links between stress and weight gain during times of crisis.", "doi": "10.1007/s10943-021-01196-8", "pmid": "33611679", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10943-021-01196-8"}], "notes": [], "created": "2021-02-22T11:50:52.955Z", "modified": "2021-02-26T08:47:00.290Z"}, {"entity": "publication", "iuid": "d17e971be14a4a93a6cff389f61af531", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d17e971be14a4a93a6cff389f61af531.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d17e971be14a4a93a6cff389f61af531"}}, "title": "Separation of power and expertise: Evidence of the tyranny of experts in Sweden's COVID-19 responses.", "authors": [{"family": "Bylund", "given": "Per L", "initials": "PL"}, {"family": "Packard", "given": "Mark D", "initials": "MD"}], "type": "journal article", "published": "2021-02-19", "journal": {"title": "South Econ J", "issn": "0038-4038", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Whereas most countries in the COVID-19 pandemic imposed shutdowns and curfews to mitigate the contagion, Sweden uniquely pursued a more voluntarist approach. In this article, our interest is primarily on how and why Sweden's approach to the pandemic was so unique. There are two parts to this research question: (1) why did virtually all other nations follow a radical lockdown protocol despite limited evidence to its effectiveness and (2) why did Sweden not follow this same protocol despite strong political pressures? The answers to these questions lie within typical government technocracy versus Sweden's constitutional separation of government and technocracy. We review the history of the responses to the pandemic and show how the \"tyranny of experts\" was severe within the typical technocratic policy response, and attenuated in Sweden's. Thus, the recent pandemic offers empirical evidence and insights regarding the role of Hayekian knowledge problems in engendering a technocratic \"tyranny of experts\" and how such effects can be structurally mitigated.", "doi": "10.1002/soej.12493", "pmid": "33821054", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "SOEJ12493"}, {"db": "pmc", "key": "PMC8014802"}], "notes": [], "created": "2021-04-07T10:11:20.636Z", "modified": "2021-04-07T10:11:49.163Z"}, {"entity": "publication", "iuid": "d90e9a3eae6845369c634f138fa5ee49", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d90e9a3eae6845369c634f138fa5ee49.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d90e9a3eae6845369c634f138fa5ee49"}}, "title": "Promoting Mental Health and Well-Being among Adolescent Young Carers in Europe: A Randomized Controlled Trial Protocol.", "authors": [{"family": "Casu", "given": "Giulia", "initials": "G"}, {"family": "Hlebec", "given": "Valentina", "initials": "V"}, {"family": "Boccaletti", "given": "Licia", "initials": "L"}, {"family": "Bolko", "given": "Irena", "initials": "I"}, {"family": "Manattini", "given": "Alessandra", "initials": "A"}, {"family": "Hanson", "given": "Elizabeth", "initials": "E"}], "type": "journal article", "published": "2021-02-19", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "4", "pages": null}, "abstract": "It is estimated that 4-8% of youth in Europe carry out substantial care for a family member or significant other. To prevent adverse psychosocial outcomes in young carers (YCs), primary prevention resilience building interventions have been recommended. We describe the study protocol of an international randomized controlled trial (RCT) of an innovative group intervention designed to promote the mental health and well-being of adolescent YCs (AYCs) aged 15-17. The RCT will be conducted in six European countries in the context of the Horizon 2020 European funded research and innovation project \"Psychosocial support for promoting mental health and well-being among adolescent young caregivers in Europe\" (\"ME-WE\"). The ME-WE intervention is based on Hayes and Ciarrochi's psychoeducational model for adolescents and will consist of seven 2-h sessions in a group format, aimed to help AYCs build psychological flexibility and live according to their values. The control group will be a waitlist. Primary and secondary outcomes and control variables will be measured at baseline (T0), post-intervention (T1) and 3 months follow-up (T2). The COVID-19 pandemic has made amendments necessary to the original study protocol methodology, which we describe in detail. This study will contribute to building an evidence-based manualized program that educators and health and social care professionals can use to support AYCs in their transition to adulthood. From a research perspective, the outcomes of this study will contribute to evidence-based practices in primary prevention of psychosocial difficulties in AYCs and will gather novel knowledge on the effectiveness of Hayes and Ciarrochi's model for use with middle adolescents with caring responsibilities. The trial has been preregistered (registration number: NCT04114864).", "doi": "10.3390/ijerph18042045", "pmid": "33669796", "labels": {"Category: Public Health": null, "Type: Journal article": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "ijerph18042045"}, {"db": "ClinicalTrials.gov", "key": "NCT04114864"}], "notes": [], "created": "2021-03-08T10:54:03.463Z", "modified": "2021-06-18T12:16:05.877Z"}, {"entity": "publication", "iuid": "681a63ed4b294f4abe9209a1d989d4e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/681a63ed4b294f4abe9209a1d989d4e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/681a63ed4b294f4abe9209a1d989d4e7"}}, "title": "Opposing Vaccine Hesitancy During the Covid-19 Pandemic - A Critical Commentary and United Statement of an International Osteopathic Research Community.", "authors": [{"family": "Thomson", "given": "Oliver P", "initials": "OP"}, {"family": "MacMillan", "given": "Andrew", "initials": "A"}, {"family": "Draper-Rodi", "given": "Jerry", "initials": "J"}, {"family": "Vaucher", "given": "Paul", "initials": "P"}, {"family": "M\u00e9nard", "given": "Mathieu", "initials": "M"}, {"family": "Vaughan", "given": "Brett", "initials": "B"}, {"family": "Morin", "given": "Chantal", "initials": "C"}, {"family": "Alvarez", "given": "Gerard", "initials": "G"}, {"family": "Sampath", "given": "Kesava Kovanur", "initials": "KK"}, {"family": "Cerritelli", "given": "Francesco", "initials": "F"}, {"family": "Shaw", "given": "Robert", "initials": "R"}, {"family": "Cymet", "given": "Tyler C", "initials": "TC"}, {"family": "Bright", "given": "Philip", "initials": "P"}, {"family": "Hohenschurz-Schmidt", "given": "David", "initials": "D"}, {"family": "Vogel", "given": "Steven", "initials": "S"}], "type": "editorial", "published": "2021-02-19", "journal": {"title": "Int J Osteopath Med", "issn": "1746-0689", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.ijosm.2021.02.002", "pmid": "33623534", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1746-0689(21)00005-5"}, {"db": "pmc", "key": "PMC7893309"}], "notes": [], "created": "2021-02-25T10:11:47.768Z", "modified": "2021-02-25T10:11:53.052Z"}, {"entity": "publication", "iuid": "3d38032e50e44e79976f38229ffa6e4f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3d38032e50e44e79976f38229ffa6e4f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3d38032e50e44e79976f38229ffa6e4f"}}, "title": "Notes from afar: reflections from two Australian intensivists in Sweden during the COVID-19 pandemic.", "authors": [{"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Halliday", "given": "Thomas", "initials": "T"}], "type": "letter", "published": "2021-02-19", "journal": {"title": "Med J Aust", "issn": "1326-5377", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.5694/mja2.50949", "pmid": "33608964", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-22T11:49:45.169Z", "modified": "2021-02-22T11:49:45.191Z"}, {"entity": "publication", "iuid": "6118df012a05421baa922beeefe40c9f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6118df012a05421baa922beeefe40c9f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6118df012a05421baa922beeefe40c9f"}}, "title": "Microsurgery training during COVID-19 pandemic: Practical recommendations from the International Society for Experimental Microsurgery and International Microsurgery Simulation Society.", "authors": [{"family": "Oltean", "given": "Mihai", "initials": "M"}, {"family": "Nistor", "given": "Alexandru", "initials": "A"}, {"family": "Hellstr\u00f6m", "given": "Mats", "initials": "M"}, {"family": "Axelsson", "given": "Michael", "initials": "M"}, {"family": "Yagi", "given": "Shintaro", "initials": "S"}, {"family": "Kobayashi", "given": "Eiji", "initials": "E"}, {"family": "Ballestin", "given": "Alberto", "initials": "A"}, {"family": "Akelina", "given": "Yelena", "initials": "Y"}, {"family": "Nemeth", "given": "Norbert", "initials": "N"}], "type": "editorial", "published": "2021-02-19", "journal": {"title": "Microsurgery", "issn": "1098-2752", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1002/micr.30725", "pmid": "33606305", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-22T11:47:59.892Z", "modified": "2021-02-22T11:49:22.216Z"}, {"entity": "publication", "iuid": "a7817eb57bdf490c9e490c19a8dabe4f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7817eb57bdf490c9e490c19a8dabe4f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7817eb57bdf490c9e490c19a8dabe4f"}}, "title": "Different disease, same challenges: Social determinants of tuberculosis and COVID-19.", "authors": [{"family": "Duarte", "given": "R", "initials": "R"}, {"family": "Aguiar", "given": "A", "initials": "A"}, {"family": "Pinto", "given": "M", "initials": "M"}, {"family": "Furtado", "given": "I", "initials": "I"}, {"family": "Tiberi", "given": "S", "initials": "S"}, {"family": "L\u00f6nnroth", "given": "K", "initials": "K"}, {"family": "Migliori", "given": "G B", "initials": "GB"}], "type": "journal article", "published": "2021-02-19", "journal": {"title": "Pulmonology", "issn": "2531-0437", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Infectious diseases, such as tuberculosis (TB) and the novel coronavirus (COVID-19) relate to environmental factors, understanding of which is essential to inform policy and practice and tackle them effectively. The review follows the conceptual framework offered by the World Health Organization Commission on Social Determinants of Health (defined as \"all those material, psychological and behavioural circumstances linked to health and generically indicated as risk factors' in the conventional epidemiological language\"). It describes the social factors behind TB and COVID-19, the commonalities between the two diseases, and what can be learned so far from the published best practices. The social determinants sustaining TB and COVID-19 underline the importance of prioritising health and allocating adequate financial and human resources to achieve universal health coverage and health-related social protection while addressing the needs of vulnerable populations. Rapid and effective measures against poverty and other major social determinants and sources of inequality are urgently needed to develop better health in the post-COVID-19 world.", "doi": "10.1016/j.pulmoe.2021.02.002", "pmid": "33648891", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S2531-0437(21)00048-9"}], "notes": [], "created": "2021-03-03T17:00:21.196Z", "modified": "2021-06-18T12:27:09.827Z"}, {"entity": "publication", "iuid": "51a1f0cc535542d8a7e55dbdad9731ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/51a1f0cc535542d8a7e55dbdad9731ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/51a1f0cc535542d8a7e55dbdad9731ef"}}, "title": "COVID-19: From health crises to food security anxiety and policy implications.", "authors": [{"family": "Chiwona-Karltun", "given": "Linley", "initials": "L"}, {"family": "Amuakwa-Mensah", "given": "Franklin", "initials": "F"}, {"family": "Wamala-Larsson", "given": "Caroline", "initials": "C"}, {"family": "Amuakwa-Mensah", "given": "Salome", "initials": "S"}, {"family": "Abu Hatab", "given": "Assem", "initials": "A"}, {"family": "Made", "given": "Nolwandle", "initials": "N"}, {"family": "Taremwa", "given": "Nathan Kanuma", "initials": "NK"}, {"family": "Melyoki", "given": "Lemayon", "initials": "L"}, {"family": "Rutashobya", "given": "Lettice Kinunda", "initials": "LK"}, {"family": "Madonsela", "given": "Thulisile", "initials": "T"}, {"family": "Lourens", "given": "Marna", "initials": "M"}, {"family": "Stone", "given": "Wendy", "initials": "W"}, {"family": "Bizoza", "given": "Alfred R", "initials": "AR"}], "type": "journal article", "published": "2021-02-19", "journal": {"title": "Ambio", "issn": "1654-7209", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Like the rest of the world, African countries are reeling from the health, economic and social effects of COVID-19. The continent's governments have responded by imposing rigorous lockdowns to limit the spread of the virus. The various lockdown measures are undermining food security, because stay at home orders have among others, threatened food production for a continent that relies heavily on agriculture as the bedrock of the economy. This article draws on quantitative data collected by the GeoPoll, and, from these data, assesses the effect of concern about the local spread and economic impact of COVID-19 on food worries. Qualitative data comprising 12 countries south of the Sahara reveal that lockdowns have created anxiety over food security as a health, economic and human rights/well-being issue. By applying a probit model, we find that concern about the local spread of COVID-19 and economic impact of the virus increases the probability of food worries. Governments have responded with various efforts to support the neediest. By evaluating the various policies rolled out we advocate for a feminist economics approach that necessitates greater use of data analytics to predict the likely impacts of intended regulatory relief responses during the recovery process and post-COVID-19.", "doi": "10.1007/s13280-020-01481-y", "pmid": "33606247", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s13280-020-01481-y"}], "notes": [], "created": "2021-02-22T11:45:22.176Z", "modified": "2021-06-18T12:28:21.236Z"}, {"entity": "publication", "iuid": "67a263a9b3b24ca9bf17cf8e24179ae6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/67a263a9b3b24ca9bf17cf8e24179ae6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/67a263a9b3b24ca9bf17cf8e24179ae6"}}, "title": "Transparency in Negotiation of European Union With Big Pharma on COVID-19 Vaccines.", "authors": [{"family": "Sciacchitano", "given": "Salvatore", "initials": "S"}, {"family": "Bartolazzi", "given": "Armando", "initials": "A"}], "type": "journal article", "published": "2021-02-18", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "issue": null, "pages": "647955", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2021.647955", "pmid": "33681138", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7930234"}], "notes": [], "created": "2021-03-09T15:35:17.044Z", "modified": "2021-03-09T15:38:10.721Z"}, {"entity": "publication", "iuid": "c811df8a6c9740759e2469610833548b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c811df8a6c9740759e2469610833548b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c811df8a6c9740759e2469610833548b"}}, "title": "Primary Immunodeficiencies: A Decade of Progress and a Promising Future.", "authors": [{"family": "Meyts", "given": "Isabelle", "initials": "I"}, {"family": "Bousfiha", "given": "Aziz", "initials": "A"}, {"family": "Duff", "given": "Carla", "initials": "C"}, {"family": "Singh", "given": "Surjit", "initials": "S"}, {"family": "Lau", "given": "Yu Lung", "initials": "YL"}, {"family": "Condino-Neto", "given": "Antonio", "initials": "A"}, {"family": "Bezrodnik", "given": "Liliana", "initials": "L"}, {"family": "Ali", "given": "Adli", "initials": "A"}, {"family": "Adeli", "given": "Mehdi", "initials": "M"}, {"family": "Drabwell", "given": "Jose", "initials": "J"}], "type": "journal article", "published": "2021-02-18", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "11", "issue": null, "pages": "625753", "issn-l": "1664-3224"}, "abstract": null, "doi": "10.3389/fimmu.2020.625753", "pmid": "33679719", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7935502"}], "notes": [], "created": "2021-03-09T15:37:08.145Z", "modified": "2021-03-09T15:37:08.155Z"}, {"entity": "publication", "iuid": "4262013c82c143d8991de666f365484f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4262013c82c143d8991de666f365484f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4262013c82c143d8991de666f365484f"}}, "title": "Open Schools, Covid-19, and Child and Teacher Morbidity in Sweden.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF", "orcid": "0000-0003-1024-5602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1d5e45881a7469ca20a0eb360d891cc.json"}}, {"family": "Engerstr\u00f6m", "given": "Lars", "initials": "L"}, {"family": "Nordenh\u00e4ll", "given": "Charlotta", "initials": "C"}, {"family": "Larsson", "given": "Emma", "initials": "E"}], "type": "letter", "published": "2021-02-18", "journal": {"title": "N Engl J Med", "issn": "1533-4406", "issn-l": null, "volume": "384", "issue": "7", "pages": "669-671"}, "abstract": "Letter to Editor", "doi": "10.1056/NEJMc2026670", "pmid": "33406327", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7821981"}], "notes": [], "created": "2021-01-07T09:53:32.558Z", "modified": "2023-01-05T09:34:44.061Z"}, {"entity": "publication", "iuid": "dbba08ac3a844ce3a632411d77f7c4f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dbba08ac3a844ce3a632411d77f7c4f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dbba08ac3a844ce3a632411d77f7c4f0"}}, "title": "Mortality of the COVID-19 Outbreak in Sweden in Relation to Previous Severe Disease Outbreaks.", "authors": [{"family": "Ledberg", "given": "Anders", "initials": "A"}], "type": "historical article", "published": "2021-02-18", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "issue": null, "pages": "579948", "issn-l": "2296-2565"}, "abstract": "Influenza viruses have caused disease outbreaks in human societies for a long time. Influenza often has rapid onset and relatively short duration, both in the individual and in the population. The case fatality rate varies for different strains of the virus, as do the effects on total mortality. Outbreaks related to coronavirus infections have recently become a global concern but much less is known about the dynamics of these outbreaks and their effects on mortality. In this work, disease outbreaks in Sweden, in the time period of 1860-2020, are characterized and compared to the currently ongoing COVID-19 outbreak. The focus is on outbreaks with a sharp increase in all-cause mortality. Outbreak onset is defined as the time point when death counts start to increase consistently for a period of at least 10 days. The duration of the outbreak is defined as the time period in which mortality rates are elevated. Excess mortality is estimated by standard methods. In total there were 15 outbreaks detected in the time period, the first 14 were likely caused by influenza virus infections, the last by SARS-CoV-2. The mortality dynamics of the SARS-CoV-2 outbreak is shown to be similar to outbreaks due to influenza virus, and in terms of the number of excess deaths, it is the worst outbreak in Sweden since the \"Spanish flu\" of 1918-1919.", "doi": "10.3389/fpubh.2021.579948", "pmid": "33681118", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7930003"}], "notes": [], "created": "2021-03-09T15:34:43.443Z", "modified": "2023-01-13T14:42:10.712Z"}, {"entity": "publication", "iuid": "56fe137526f642b09109307e1e3d002c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56fe137526f642b09109307e1e3d002c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56fe137526f642b09109307e1e3d002c"}}, "title": "COVID-19: A methyl-group assault?", "authors": [{"family": "McCaddon", "given": "Andrew", "initials": "A"}, {"family": "Regland", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2021-02-18", "journal": {"title": "Med Hypotheses", "issn": "1532-2777", "volume": "149", "issue": null, "pages": "110543", "issn-l": null}, "abstract": "The socio-economic implications of COVID-19 are devastating. Considerable morbidity is attributed to 'long-COVID' - an increasingly recognized complication of infection. Its diverse symptoms are reminiscent of vitamin B 12 deficiency, a condition in which methylation status is compromised. We suggest why SARS-CoV-2 infection likely leads to increased methyl-group requirements and other disturbances of one-carbon metabolism. We propose these might explain the varied symptoms of long-COVID. Our suggested mechanismmight also apply to similar conditions such as myalgic encephalomyelitis/chronic fatigue syndrome. The hypothesis is evaluable by detailed determination of vitamin B12and folate status, including serum formate as well as homocysteine and methylmalonic acid, and correlation with viral and host RNA methylation and symptomatology. If confirmed, methyl-group support should prove beneficial in such individuals.", "doi": "10.1016/j.mehy.2021.110543", "pmid": "33657459", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0306-9877(21)00061-X"}], "notes": [], "created": "2021-03-04T14:56:44.491Z", "modified": "2021-03-04T14:56:44.501Z"}, {"entity": "publication", "iuid": "2776c89c8fbb490faa3383929ae5e355", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2776c89c8fbb490faa3383929ae5e355.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2776c89c8fbb490faa3383929ae5e355"}}, "title": "No Apparent Increase in Treatment Uptake for Gambling Disorder during Ten Months of the COVID-19 Pandemic-Analysis of a Regional Specialized Treatment Unit in Sweden.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "\u00c5kesson", "given": "Gunny", "initials": "G"}, {"family": "Grudet", "given": "C\u00e9cile", "initials": "C"}, {"family": "Broman", "given": "Niroshani", "initials": "N"}], "type": "journal article", "published": "2021-02-17", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "4", "pages": null}, "abstract": "The COVID-19 pandemic and its impact on society has been suspected to affect gambling behaviors. Potentially, the pandemic crisis may result in increased problem gambling, for example, due to COVID-19-related psychological distress, unemployment, and financial difficulties. In addition, the cancellation of sports in early parts of the crisis has been suspected to alter gambling behaviors. Policy makers have called for action and, in some cases, have changed regulations, and media have reported possible increases in treatment seeking. However, research data are hitherto lacking. The present study assessed the treatment uptake at a regional specialized gambling-disorder unit in the healthcare system of Region Sk\u00e5ne, Sweden. Number of patients, treatment contacts, and patterns of rescheduling or cancellations of appointments were quantified for each month, January-December 2020, and compared to corresponding months of 2018 and 2019. Possible trends were analyzed, using an interrupted time-series analysis. Results did not indicate an increase in treatment uptake for gambling disorder during the months of COVID-19 impact in Sweden. The proportion of digital treatment increased, but total treatment uptake was unaffected by the pandemic. In conclusion, during the first ten months of the pandemic in Sweden, no obvious increase in treatment uptake for gambling disorder could be seen. Moreover, longer follow-up may be necessary in order to see if effects of worsening socioeconomic conditions may be a possible long-term risk factor of increased gambling after COVID-19.", "doi": "10.3390/ijerph18041918", "pmid": "33671210", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph18041918"}], "notes": [], "created": "2021-03-08T10:55:33.867Z", "modified": "2021-06-18T12:13:22.550Z"}, {"entity": "publication", "iuid": "4fd3a6db29284949ba20ab51f116fca8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4fd3a6db29284949ba20ab51f116fca8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4fd3a6db29284949ba20ab51f116fca8"}}, "title": "Impacts of COVID-19 on long-term health and health care use", "authors": [{"family": "Skyrud", "given": "Katrine", "initials": "K", "orcid": "0000-0001-7504-9253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa7b45c41c544ba098093febd55117c8.json"}}, {"family": "Hern\u00e6s", "given": "Kjersti Helene", "initials": "KH"}, {"family": "Telle", "given": "Kjetil", "initials": "K", "orcid": "0000-0002-7978-0825", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21c273a80c5c4976bd93f15f2e038f40.json"}}, {"family": "Magnusson", "given": "Karin", "initials": "K", "orcid": "0000-0003-4851-5794", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2fe6a28f36f40a998b8c9fc3c5ebe73.json"}}], "type": "posted-content", "published": "2021-02-17", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.16.21251807", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-18T11:03:10.874Z", "modified": "2022-11-22T05:53:14.152Z"}, {"entity": "publication", "iuid": "c5613dca3ecd449180e010846b313144", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5613dca3ecd449180e010846b313144.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5613dca3ecd449180e010846b313144"}}, "title": "Association between cardiometabolic disease and severe COVID-19: a nationwide case-control study of patients requiring invasive mechanical ventilation.", "authors": [{"family": "Svensson", "given": "Per", "initials": "P"}, {"family": "Hofmann", "given": "Robin", "initials": "R"}, {"family": "H\u00e4bel", "given": "Henrike", "initials": "H"}, {"family": "Jernberg", "given": "Tomas", "initials": "T"}, {"family": "Nordberg", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2021-02-17", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "2", "pages": "e044486"}, "abstract": "The risks associated with diabetes, obesity and hypertension for severe COVID-19 may be confounded and differ by sociodemographic background. We assessed the risks associated with cardiometabolic factors for severe COVID-19 when accounting for socioeconomic factors and in subgroups by age, sex and region of birth.\r\n\r\nIn this nationwide case-control study, 1.086 patients admitted to intensive care with COVID-19 requiring mechanical ventilation (cases), and 10.860 population-based controls matched for age, sex and district of residency were included from mandatory national registries. ORs with 95% CIs for associations between severe COVID-19 and exposures with adjustment for confounders were estimated using logistic regression. The median age was 62 years (IQR 52-70), and 3003 (24.9%) were women. Type 2 diabetes (OR, 2.3 (95% CI 1.9 to 2.7)), hypertension (OR, 1.7 (95% CI 1.5 to 2.0)), obesity (OR, 3.1 (95% CI 2.4 to 4.0)) and chronic kidney disease (OR, 2.5 (95% CI 1.7 to 3.7)) were all associated with severe COVID-19. In the younger subgroup (below 57 years), ORs were significantly higher for all cardiometabolic risk factors. The risk associated with type 2 diabetes was higher in women (p=0.001) and in patients with a region of birth outside European Union(EU) (p=0.004).\r\n\r\nDiabetes, obesity and hypertension were all independently associated with severe COVID-19 with stronger associations in the younger population. Type 2 diabetes implied a greater risk among women and in non-EU immigrants. These findings, originating from high-quality Swedish registries, may be important to direct preventive measures such as vaccination to susceptible patient groups.\r\n\r\nClinicaltrial.gov (NCT04426084).", "doi": "10.1136/bmjopen-2020-044486", "pmid": "33597145", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-044486"}, {"db": "ClinicalTrials.gov", "key": "NCT04426084"}], "notes": [], "created": "2021-02-19T06:22:45.933Z", "modified": "2021-06-18T12:06:53.712Z"}, {"entity": "publication", "iuid": "4b0f1b1ea560426c8ef9e4bb44326d3f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b0f1b1ea560426c8ef9e4bb44326d3f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b0f1b1ea560426c8ef9e4bb44326d3f"}}, "title": "Extracorporeal Life Support in COVID-19-related Acute Respiratory Distress Syndrome - a EuroELSO international survey.", "authors": [{"family": "Mang", "given": "Sebastian", "initials": "S"}, {"family": "Kalenka", "given": "Armin", "initials": "A"}, {"family": "Broman", "given": "Lars Mikael", "initials": "LM"}, {"family": "Supady", "given": "Alexander", "initials": "A"}, {"family": "Swol", "given": "Justyna", "initials": "J"}, {"family": "Danziger", "given": "Guy", "initials": "G"}, {"family": "Becker", "given": "Andr\u00e9", "initials": "A"}, {"family": "H\u00f6rsch", "given": "Sabrina I", "initials": "SI"}, {"family": "Mertke", "given": "Thilo", "initials": "T"}, {"family": "Kaiser", "given": "Ralf", "initials": "R"}, {"family": "Bracht", "given": "Hendrik", "initials": "H"}, {"family": "Zotzmann", "given": "Viviane", "initials": "V"}, {"family": "Seiler", "given": "Frederik", "initials": "F"}, {"family": "Bals", "given": "Robert", "initials": "R"}, {"family": "Taccone", "given": "Fabio Silvio", "initials": "FS"}, {"family": "Moerer", "given": "Onnen", "initials": "O"}, {"family": "Lorusso", "given": "Roberto", "initials": "R"}, {"family": "B\u011blohl\u00e1vek", "given": "Jan", "initials": "J"}, {"family": "Muellenbach", "given": "Ralf M", "initials": "RM"}, {"family": "Lepper", "given": "Philipp M", "initials": "PM"}, {"family": "COVEC-Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-02-16", "journal": {"title": "Artif Organs", "issn": "1525-1594", "volume": null, "issue": null, "issn-l": null}, "abstract": "Extracorporeal life support (ECLS) is a means to support patients with acute respiratory failure. Initially, recommendations to treat severe cases of pandemic Coronavirus Disease 2019 (COVID-19) with ECLS have been restrained. In the meantime, ECLS has been shown to produce similar outcomes in patients with severe COVID-19 compared to existing data on ARDS mortality.\n\nWe performed an international email survey to assess how ECLS providers worldwide have previously used ECLS during the treatment of critically ill patients with COVID-19.\n\nA questionnaire with 45 questions (covering e.g. indication, technical aspects, benefit and reasons for treatment discontinuation), mostly multiple-choice, was distributed by email to ECLS centers. The survey was approved by the European branch of the Extracorporeal Life Support Organization (ELSO).\n\n276 ECMO professionals from 98 centers in 30 different countries on four continents reported that they employed ECMO for very severe COVID-19 cases, mostly in veno-venous configuration (87%). The most common reason to establish ECLS was isolated hypoxemic respiratory failure (50%), followed by a combination of hypoxemia and hypercapnia (39%). Only a small fraction of patients required veno-arterial cannulation due to heart failure (3%). Time on ECLS varied between less than two and more than four weeks. The main reason to discontinue ECLS treatment prior to patient's recovery was lack of clinical improvement (53%), followed by major bleeding, mostly intracranially (13%). Only 4% of respondents reported that triage situations, lack of staff or lack of oxygenators were responsible for discontinuation of ECLS support. Most ECLS physicians (51%, IQR 30%) agreed that patients with COVID-19 induced ARDS (CARDS) benefitted from ECLS. Overall mortality of COVID-19 patients on ECLS was estimated to be about 55%.\n\nECLS has been utilized successfully during the COVID-19 pandemic to stabilize CARDS patients in hypoxemic or hypercapnic lung failure. Age and multimorbidity limited the use of ECLS. Triage situations were rarely a concern. ECLS providers stated that patients with severe COVID-19 benefitted from ECLS.", "doi": "10.1111/aor.13940", "pmid": "33590542", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-02-17T15:04:16.789Z", "modified": "2021-02-17T15:05:18.711Z"}, {"entity": "publication", "iuid": "93685b21b5ce4554bb28daffb4ac1ddb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/93685b21b5ce4554bb28daffb4ac1ddb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/93685b21b5ce4554bb28daffb4ac1ddb"}}, "title": "SARS-CoV2 envelop proteins reshape the serological responses of COVID-19 patients", "authors": [{"family": "Martin", "given": "Sophie", "initials": "S"}, {"family": "Heslan", "given": "Christopher", "initials": "C"}, {"family": "Jegou", "given": "Gwenaele", "initials": "G"}, {"family": "Eriksson", "given": "Leif A", "initials": "LA"}, {"family": "Le Gallo", "given": "Matthieu", "initials": "M"}, {"family": "Thibault", "given": "Vincent", "initials": "V"}, {"family": "Chevet", "given": "Eric", "initials": "E"}, {"family": "Avril", "given": "Tony", "initials": "T"}], "type": "posted-content", "published": "2021-02-15", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.15.431237", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-02-16T15:10:29.773Z", "modified": "2021-03-08T15:06:49.441Z"}, {"entity": "publication", "iuid": "b958e83e0e8d45cfa85481fec9b4d055", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b958e83e0e8d45cfa85481fec9b4d055.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b958e83e0e8d45cfa85481fec9b4d055"}}, "title": "Identification of endothelial-derived proteins in plasma associated with cardiovascular risk factors", "authors": [{"family": "Iglesias", "given": "MJ", "initials": "M"}, {"family": "LD", "given": "Kruse", "initials": "K"}, {"family": "Sanchez-Rivera", "given": "L", "initials": "L"}, {"family": "Enge", "given": "L", "initials": "L"}, {"family": "Dusart", "given": "P", "initials": "P"}, {"family": "Hong", "given": "MG", "initials": "M"}, {"family": "M Uhl\u00e9n", "given": "M", "initials": "M"}, {"family": "Renn\u00e9", "given": "T", "initials": "T"}, {"family": "Schwenk", "given": "JM", "initials": "J"}, {"family": "Bergstrom", "given": "G", "initials": "G"}, {"family": "Odeberg", "given": "J", "initials": "J"}, {"family": "Butler", "given": "LM", "initials": "L"}], "type": null, "published": "2021-02-15", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "https://doi.org/10.1101/2021.02.08.21251209", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-15T18:28:29.299Z", "modified": "2021-02-26T08:45:48.606Z"}, {"entity": "publication", "iuid": "27d452f2a66c49e18ad440c11fbe7456", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27d452f2a66c49e18ad440c11fbe7456.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27d452f2a66c49e18ad440c11fbe7456"}}, "title": "European Task Force on Atopic Dermatitis (ETFAD): position on vaccination of adult patients with atopic dermatitis against COVID-19 (SARS-CoV-2) being treated with systemic medication and biologics.", "authors": [{"family": "Thyssen", "given": "Jacob P", "initials": "JP"}, {"family": "Vestergaard", "given": "Christian", "initials": "C"}, {"family": "Barbarot", "given": "Sebastien", "initials": "S"}, {"family": "de Bruin-Weller", "given": "Marjolein S", "initials": "MS"}, {"family": "Bieber", "given": "Thomas", "initials": "T"}, {"family": "Taieb", "given": "Alain", "initials": "A"}, {"family": "Seneschal", "given": "Julien", "initials": "J"}, {"family": "Cork", "given": "Michael J", "initials": "MJ"}, {"family": "Paul", "given": "Carle", "initials": "C"}, {"family": "Flohr", "given": "Carsten", "initials": "C"}, {"family": "Weidinger", "given": "Stephan", "initials": "S"}, {"family": "Trzeciak", "given": "Magdalena", "initials": "M"}, {"family": "Werfel", "given": "Thomas", "initials": "T"}, {"family": "Heratizadeh", "given": "Annice", "initials": "A"}, {"family": "Darsow", "given": "Ulf", "initials": "U"}, {"family": "Simon", "given": "Dagmar", "initials": "D"}, {"family": "Torrelo", "given": "Antonio", "initials": "A"}, {"family": "Chernyshov", "given": "Pavel V", "initials": "PV"}, {"family": "Stalder", "given": "Jean-Francois", "initials": "J"}, {"family": "Gelmetti", "given": "Carlo", "initials": "C"}, {"family": "Szalai", "given": "Zsuzsanna", "initials": "Z"}, {"family": "Svensson", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "von Kobyletzki", "given": "Laura B", "initials": "LB"}, {"family": "De Raeve", "given": "Linda", "initials": "L"}, {"family": "F\u00f6lster-Holst", "given": "Regina", "initials": "R"}, {"family": "Christen-Zaech", "given": "St\u00e9phanie", "initials": "S"}, {"family": "Jan Hijnen", "given": "Dirk", "initials": "D"}, {"family": "Gieler", "given": "Uwe", "initials": "U"}, {"family": "Gutermuth", "given": "Jan", "initials": "J"}, {"family": "Bangert", "given": "Christine", "initials": "C"}, {"family": "Spuls", "given": "Phyllis I", "initials": "PI"}, {"family": "Kunz", "given": "Barbara", "initials": "B"}, {"family": "Ring", "given": "Johannes", "initials": "J"}, {"family": "Wollenberg", "given": "Andreas", "initials": "A"}, {"family": "Deleuran", "given": "Mette", "initials": "M"}], "type": "journal article", "published": "2021-02-15", "journal": {"title": "J Eur Acad Dermatol Venereol", "issn": "1468-3083", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic is caused by rapid spread of different strains of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The severity of infection ranges from mild, or even asymptomatic, to very severe. Signs and symptoms include fatigue, fever, exanthemas, upper respiratory illness, loss of smell and taste, pneumonia, severe acute respiratory syndrome, and multi-organ failure. Risk factors for a severe or lethal course include age, male gender, obesity, diabetes, cardiovascular disease, and immune suppression 1 .", "doi": "10.1111/jdv.17167", "pmid": "33587756", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-17T14:50:53.614Z", "modified": "2021-02-17T14:51:23.369Z"}, {"entity": "publication", "iuid": "b70af2764edf45d598cb8546b2df3aec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b70af2764edf45d598cb8546b2df3aec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b70af2764edf45d598cb8546b2df3aec"}}, "title": "Comprehensive Landscape of Heparin Therapy for COVID-19.", "authors": [{"family": "Shi", "given": "Chen", "initials": "C"}, {"family": "Tingting", "given": "Wu", "initials": "W"}, {"family": "Li", "given": "Jin-Ping", "initials": "JP"}, {"family": "Sullivan", "given": "Mitchell A", "initials": "MA"}, {"family": "Wang", "given": "Cong", "initials": "C"}, {"family": "Wang", "given": "Hanxiang", "initials": "H"}, {"family": "Deng", "given": "Bin", "initials": "B"}, {"family": "Zhang", "given": "Yu", "initials": "Y"}], "type": "journal article", "published": "2021-02-15", "journal": {"title": "Carbohydr Polym", "issn": "1879-1344", "issn-l": null, "volume": "254", "issue": null, "pages": "117232"}, "abstract": "The pandemic coronavirus disease 2019 (COVID-19), caused by the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading globally. Clinical observations found that systemic symptoms caused by SARS-CoV-2 infection are attenuated when using the anticoagulant agent heparin, indicating that heparin may play other roles in managing COVID-19, in addition to prevention of pulmonary thrombosis. Several biochemical studies show strong binding of heparin and heparin-like molecules to the Spike protein, which resulted in inhibition of viral infection to cells. The clinical observations and in vitro studies argue for a potential multiple-targeting effects of heparin. However, adverse effects of heparin administration and some of the challenges using heparin therapy for SARS-CoV-2 infection need to be considered. This review discusses the pharmacological mechanisms of heparin regarding its anticoagulant, anti-inflammatory and direct antiviral activities, providing current evidence concerning the effectiveness and safety of heparin therapy for this major public health emergency.", "doi": "10.1016/j.carbpol.2020.117232", "pmid": "33357843", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7581413"}, {"db": "pii", "key": "S0144-8617(20)31405-3"}], "notes": [], "created": "2021-01-10T17:29:41.591Z", "modified": "2023-06-19T15:36:36.473Z"}, {"entity": "publication", "iuid": "672f02017ba74c67be57dbacfb81707b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/672f02017ba74c67be57dbacfb81707b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/672f02017ba74c67be57dbacfb81707b"}}, "title": "Single-cell sequencing of plasma cells from COVID-19 patients reveals highly expanded clonal lineages produce specific and neutralizing antibodies to SARS-CoV-2", "authors": [{"family": "Ehling", "given": "Roy A", "initials": "RA"}, {"family": "Weber", "given": "C\u00e9dric R", "initials": "CR"}, {"family": "Mason", "given": "Derek M", "initials": "DM"}, {"family": "Friedensohn", "given": "Simon", "initials": "S"}, {"family": "Wagner", "given": "Bastian", "initials": "B"}, {"family": "Bieberich", "given": "Florian", "initials": "F"}, {"family": "Kapetanovic", "given": "Edo", "initials": "E"}, {"family": "Vazquez-Lombardi", "given": "Rodrigo", "initials": "R"}, {"family": "Di Roberto", "given": "Rapha\u00ebl B", "initials": "RB"}, {"family": "Hong", "given": "Kai Lin", "initials": "KL"}, {"family": "Wagner", "given": "Camille", "initials": "C"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Yermanos", "given": "Alexander", "initials": "A"}, {"family": "Cuny", "given": "Andreas P", "initials": "AP"}, {"family": "Savic", "given": "Miodrag", "initials": "M"}, {"family": "Rudolf", "given": "Fabian", "initials": "F"}, {"family": "Reddy", "given": "Sai T", "initials": "ST"}], "type": "posted-content", "published": "2021-02-12", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.12.430940", "pmid": null, "labels": {"Funder: H2020": null, "Category: Biochemistry": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-03-08T15:10:05.611Z", "modified": "2021-03-09T12:31:31.351Z"}, {"entity": "publication", "iuid": "2e8684b503454348aaab5858f9790222", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e8684b503454348aaab5858f9790222.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e8684b503454348aaab5858f9790222"}}, "title": "Quantifying the preventive effect of wearing face masks", "authors": [{"family": "Britton", "given": "Tom", "initials": "T"}], "type": "posted-content", "published": "2021-02-12", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.09.21251448", "pmid": null, "labels": {"Type: Preprint": null, "Funder: NordForsk": null, "Category: Health": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-15T18:30:28.164Z", "modified": "2021-02-26T08:46:13.012Z"}, {"entity": "publication", "iuid": "55ad8ca80a844ef99d92fc0f73089a41", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/55ad8ca80a844ef99d92fc0f73089a41.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/55ad8ca80a844ef99d92fc0f73089a41"}}, "title": "Changes in Lifestyle, Behaviors, and Risk Factors for Cognitive Impairment in Older Persons During the First Wave of the Coronavirus Disease 2019 Pandemic in Finland: Results From the FINGER Study.", "authors": [{"family": "Lehtisalo", "given": "Jenni", "initials": "J"}, {"family": "Palmer", "given": "Katie", "initials": "K"}, {"family": "Mangialasche", "given": "Francesca", "initials": "F"}, {"family": "Solomon", "given": "Alina", "initials": "A"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Ngandu", "given": "Tiia", "initials": "T"}], "type": "journal article", "published": "2021-02-12", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "issue": null, "pages": "624125", "issn-l": "1664-0640"}, "abstract": "Aims: This study aimed to describe how the first phase of the coronavirus disease 2019 (COVID-19) pandemic affected older persons from the general Finnish population who are at risk of developing or have cognitive impairment, specifically, to describe whether participants experienced a change in risk factors that are relevant for the prevention of cognitive decline including diet, physical activity, access to medical care, socially and cognitively stimulating activities, and emotional health and well-being. Method: A postal survey was sent in June 2020 to 859 participants from the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), an ongoing longitudinal study. The survey was developed to assess the effect of the COVID-19 pandemic and related infection-control measures on daily life, specifically commitment to distancing measures, access to health care and social services, daily activities, and changes in cognitive and social activities. Results: By September 2020, 613 (71%) participants responded (mean age = 77.7 years, 32% lived alone, and 80% had at least one chronic condition). Three quarters adopted some distancing practices during the first months of the pandemic. Older participants were more likely to practice total isolation than younger ones (29 vs. 19%; p = 0.003). Non-acute health-care visits were canceled for 5% of the participants who needed appointments, but cancellations in dental health care (43%), home aid (30%), and rehabilitative services (53%) were more common. Pandemic-related changes were reported in social engagements, for example, less contact with friends (55%) and family (31%), or less frequent attendance in cultural events (38%) or associations (25%), although remote contact with others increased for 40%. Feelings of loneliness increased for 21%, particularly those who were older (p = 0.023) or living alone (p < 0.001). Physical activity reduced for 34%, but dietary habits remained stable or improved. Pandemic-related changes in lifestyle and activities were more evident among those living alone. Conclusions: Finnish older persons generally reported less negative changes in lifestyles and behaviors during the pandemic than expected. Older people and those living alone seemed more susceptible to negative changes. It is important to compare how coping strategies may compare with other European countries to identify factors that may help older individuals to maintain healthy lifestyles during future waves of COVID-19.", "doi": "10.3389/fpsyt.2021.624125", "pmid": "33643095", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC7907420"}], "notes": [], "created": "2021-03-02T06:52:05.714Z", "modified": "2021-03-02T06:52:05.717Z"}, {"entity": "publication", "iuid": "d1d6dd596f3249b8bac66ef8ae32e8ec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1d6dd596f3249b8bac66ef8ae32e8ec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1d6dd596f3249b8bac66ef8ae32e8ec"}}, "title": "Tropism of SARS-CoV-2 in commonly used laboratory cell lines and their proteomic landscape during infection", "authors": [{"family": "Elisa Saccon", "given": "", "initials": ""}, {"family": "Xi Chen", "given": ".", "initials": "."}, {"family": "Flora Mikaeloff", "given": "", "initials": ""}, {"family": "jimmy Esneider Rodriguez", "given": "", "initials": ""}, {"family": "Laszlo Szekely", "given": "", "initials": ""}, {"family": "Beatriz S\u00e1 Vinhas", "given": "", "initials": ""}, {"family": "shuba Krishnan", "given": "", "initials": ""}, {"family": "Siddappa N. Byrareddy", "given": "", "initials": ""}, {"family": "Teresa Frisan", "given": "", "initials": ""}, {"family": "\u00c1kos V\u00e9gv\u00e1ri", "given": "", "initials": ""}, {"family": "Ali Mirazimi", "given": "UM", "initials": "U"}, {"family": "ujjwal Neogi", "given": "", "initials": ""}, {"family": "Gupta", "given": "Soham", "initials": "S"}], "type": "posted-content", "published": "2021-02-11", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.08.28.271684", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-02-11T15:56:44.718Z", "modified": "2021-04-23T15:15:50.301Z"}, {"entity": "publication", "iuid": "b335292c5a9a433691ef0b36bf1a765b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b335292c5a9a433691ef0b36bf1a765b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b335292c5a9a433691ef0b36bf1a765b"}}, "title": "Mechanistic and Therapeutic Implications of Extracellular Vesicles as a Potential Link Between Covid-19 and Cardiovascular Disease Manifestations.", "authors": [{"family": "Pironti", "given": "Gianluigi", "initials": "G"}, {"family": "Andersson", "given": "Daniel C", "initials": "DC"}, {"family": "Lund", "given": "Lars H", "initials": "LH"}], "type": "journal article", "published": "2021-02-11", "journal": {"title": "Front Cell Dev Biol", "issn": "2296-634X", "issn-l": null, "volume": "9", "issue": null, "pages": "640723"}, "abstract": "Extracellular vesicles (EVs), which are cell released double layered membrane particles, have been found in every circulating body fluid, and provide a tool for conveying diverse information between cells, influencing both physiological and pathological conditions. Viruses can hijack the EVs secretory pathway to exit infected cells and use EVs endocytic routes to enter uninfected cells, suggesting that EVs and viruses can share common cell entry and biogenesis mechanisms. SARS-CoV-2 is responsible of the coronavirus disease 2019 (Covid-19), which may be accompanied by severe multi-organ manifestations. EVs may contribute to virus spreading via transfer of virus docking receptors such as CD9 and ACE2. Covid-19 is known to affect the renin angiotensin system (RAS), and could promote secretion of harmful EVs. In this scenario EVs might be linked to cardiovascular manifestations of the Covid-19 disease through unbalance in RAS. In contrast EVs derived from mesenchymal stem cells or cardiosphere derived cells, may promote cardiovascular function due to their beneficial effect on angiogenesis, fibrosis, contractility and immuno-modulation. In this article we assessed the potential impact of EVs in cardiovascular manifestations of Covid-19 and highlight potential strategies to control the extracellular signaling for future therapies.", "doi": "10.3389/fcell.2021.640723", "pmid": "33644077", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7905102"}], "notes": [], "created": "2021-03-02T06:55:09.771Z", "modified": "2021-06-18T11:56:14.114Z"}, {"entity": "publication", "iuid": "7f57776f36ed41deb09c507dede3348d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f57776f36ed41deb09c507dede3348d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f57776f36ed41deb09c507dede3348d"}}, "title": "Is There an Effect of Fetal Mesenchymal Stem Cells in the Mother-Fetus Dyad in COVID-19 Pregnancies and Vertical Transmission?", "authors": [{"family": "Samara", "given": "Athina", "initials": "A"}, {"family": "Herlenius", "given": "Eric", "initials": "E"}], "type": "journal article", "published": "2021-02-11", "journal": {"title": "Front Physiol", "issn": "1664-042X", "issn-l": null, "volume": "11", "issue": null, "pages": "624625"}, "abstract": "Because of the polysystemic nature of coronavirus disease 2019 (COVID-19), during the present pandemic, there have been serious concerns regarding pregnancy, vertical transmission, and intrapartum risk. The majority of pregnant patients with COVID-19 infection present with mild or asymptomatic course of the disease. Some cases were hospitalized, and few needed intensive care unit admission, or mechanical ventilation. There have also been scarce case reports where neonates required mechanical ventilation post COVID-19 pregnancies. Without approved therapies other than dexamethasone, advanced mesenchymal cell therapy is one immunomodulatory therapeutic approach that is currently explored and might hold great promise. We suggest that the circulating fetal stem cells might have an immune-protective effect to mothers and contribute to the often mild and even asymptomatic post-COVID-19 pregnancies. Thus, COVID-19 pregnancies come forth as a paradigm to be further and more comprehensively approached, to understand both the mechanism and action of circulating stem cells in immunoprotection and hypoxia in microcirculation.", "doi": "10.3389/fphys.2020.624625", "pmid": "33679426", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7928412"}], "notes": [], "created": "2021-03-09T15:33:16.053Z", "modified": "2021-06-18T12:01:22.813Z"}, {"entity": "publication", "iuid": "4b706f8c6b6a4c2baefaf1e4c62560ed", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b706f8c6b6a4c2baefaf1e4c62560ed.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b706f8c6b6a4c2baefaf1e4c62560ed"}}, "title": "Dehumanization During the COVID-19 Pandemic", "authors": [{"family": "Markowitz", "given": "David M", "initials": "DM"}, {"family": "Shoots-Reinhard", "given": "Brittany", "initials": "B"}, {"family": "Peters", "given": "Ellen", "initials": "E"}, {"family": "Silverstein", "given": "Michael C", "initials": "MC"}, {"family": "Goodwin", "given": "Raleigh", "initials": "R"}, {"family": "Bj\u00e4lkebring", "given": "P\u00e4r", "initials": "P"}], "type": "journal-article", "published": "2021-02-11", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "issue": null, "pages": null, "issn-l": "1664-1078"}, "abstract": null, "doi": "10.3389/fpsyg.2021.634543", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-03-02T06:56:54.710Z", "modified": "2021-03-02T06:56:54.720Z"}, {"entity": "publication", "iuid": "4bd12053e8924d3fb6fa414fa0c63638", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4bd12053e8924d3fb6fa414fa0c63638.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4bd12053e8924d3fb6fa414fa0c63638"}}, "title": "Problematic internet-related behaviors mediate the associations between levels of internet engagement and distress among schoolchildren during COVID-19 lockdown: A longitudinal structural equation modeling study.", "authors": [{"family": "Chen", "given": "I-Hua", "initials": "I"}, {"family": "Chen", "given": "Chao-Ying", "initials": "C"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Li", "given": "Xu-Dong", "initials": "X"}, {"family": "Tsang", "given": "Hector W H", "initials": "HWH"}], "type": "journal article", "published": "2021-02-10", "journal": {"title": "J Behav Addict", "issn": "2063-5303", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Due to the rapid spread of the novel coronavirus disease 2019 (COVID-19), policies based on the nature of \"spatial distancing\" have been implemented and have resulted in school suspensions and online learning among schoolchildren. In order to examine the impact of such policies on schoolchildren, the aims of the present study were to (i) assess changes in the level of engagement in three internet-related activities (smartphone use, social media use, and gaming) before and during the COVID-19 outbreak, including prolonged and problematic engagement in these activities; (ii) investigate the differences of psychological distress before and after COVID-19 outbreak; and (iii) to use structural equation modeling to investigate the mediating roles of problematic internet-related behaviors in the causal relationships of psychological distress and time spent on internet-related activities.\r\n\r\nSelf-report measures were used to assess internet-related activities and psychological distress. Time spent on internet-related activities, problematic use of internet-related activities, and psychological distress were collected from primary school students (N = 535; 265 boys; M age = 10.32 years [SD = 0.84]). The data were first collected before the COVID-19 outbreak (i.e., early November 2019) and then collected again during the school suspension due to COVID-19 outbreak (i.e., end of March 2020) for comparisons of changes.\r\n\r\nSchoolchildren spent significantly more time on the smartphone (increased 1.02 h daily; P < 0.001) and social media (increased 0.73 h daily; P < 0.001) but not gaming (increased 0.14 h daily; P = 0.07) during the school suspension compared to the baseline. Schoolchildren who increased by 15 or 30 min daily on internet-related activities showed an increased level of psychological distress. The association between problematic use of social media and psychological distress was stronger during the school suspension (\u03b2 = 0.584) than at the baseline (\u03b2 = 0.451; P < 0.001).\r\n\r\nIncreased problematic use of internet-related activities among schoolchildren was associated with greater psychological distress. Parents should therefore monitor internet-related activities and psychological distress of their children to support their mental health.", "doi": "10.1556/2006.2021.00006", "pmid": "33570506", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-15T17:33:28.219Z", "modified": "2021-06-18T12:07:46.281Z"}, {"entity": "publication", "iuid": "2b523eff6797470a962feeedf8b57d7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b523eff6797470a962feeedf8b57d7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b523eff6797470a962feeedf8b57d7e"}}, "title": "Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19.", "authors": [{"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Czarlewski", "given": "Wienczyslawa", "initials": "W"}, {"family": "Zuberbier", "given": "Torsten", "initials": "T"}, {"family": "Mullol", "given": "Joaquim", "initials": "J"}, {"family": "Blain", "given": "Hubert", "initials": "H"}, {"family": "Cristol", "given": "Jean-Paul", "initials": "JP"}, {"family": "De La Torre", "given": "Rafael", "initials": "R"}, {"family": "Pizarro Lozano", "given": "Nieves", "initials": "N"}, {"family": "Le Moing", "given": "Vincent", "initials": "V"}, {"family": "Bedbrook", "given": "Anna", "initials": "A"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Akdis", "given": "Cezmi A", "initials": "CA"}, {"family": "Canonica", "given": "G Walter", "initials": "GW"}, {"family": "Cruz", "given": "Alvaro A", "initials": "AA"}, {"family": "Fiocchi", "given": "Alessandro", "initials": "A"}, {"family": "Fonseca", "given": "Joao A", "initials": "JA"}, {"family": "Fonseca", "given": "Susana", "initials": "S"}, {"family": "Gemicio\u011flu", "given": "Bilun", "initials": "B"}, {"family": "Haahtela", "given": "Tari", "initials": "T"}, {"family": "Iaccarino", "given": "Guido", "initials": "G"}, {"family": "Ivancevich", "given": "Juan Carlos", "initials": "JC"}, {"family": "Jutel", "given": "Marek", "initials": "M"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Kraxner", "given": "Helga", "initials": "H"}, {"family": "Kuna", "given": "Piotr", "initials": "P"}, {"family": "Larenas-Linnemann", "given": "D\u00e9sir\u00e9e E", "initials": "DE"}, {"family": "Martineau", "given": "Adrian", "initials": "A"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Okamoto", "given": "Yoshitaka", "initials": "Y"}, {"family": "Papadopoulos", "given": "Nikolaos G", "initials": "NG"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Regateiro", "given": "Frederico S", "initials": "FS"}, {"family": "Reynes", "given": "Jacques", "initials": "J"}, {"family": "Rolland", "given": "Yves", "initials": "Y"}, {"family": "Rouadi", "given": "Philip W", "initials": "PW"}, {"family": "Samolinski", "given": "Boleslaw", "initials": "B"}, {"family": "Sheikh", "given": "Aziz", "initials": "A"}, {"family": "Toppila-Salmi", "given": "Sanna", "initials": "S"}, {"family": "Valiulis", "given": "Arunas", "initials": "A"}, {"family": "Choi", "given": "Hak-Jong", "initials": "HJ"}, {"family": "Kim", "given": "Hyun Ju", "initials": "HJ"}, {"family": "Anto", "given": "Josep M", "initials": "JM"}], "type": "journal article", "published": "2021-02-10", "journal": {"title": "Int Arch Allergy Immunol", "issn": "1018-2438", "volume": null, "issue": null, "pages": "1-15", "issn-l": null}, "abstract": "In this article, we propose that differences in COVID-19 morbidity may be associated with transient receptor potential ankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 (TRPV1) activation as well as desensitization. TRPA1 and TRPV1 induce inflammation and play a key role in the physiology of almost all organs. They may augment sensory or vagal nerve discharges to evoke pain and several symptoms of COVID-19, including cough, nasal obstruction, vomiting, diarrhea, and, at least partly, sudden and severe loss of smell and taste. TRPA1 can be activated by reactive oxygen species and may therefore be up-regulated in COVID-19. TRPA1 and TRPV1 channels can be activated by pungent compounds including many nuclear factor (erythroid-derived 2) (Nrf2)-interacting foods leading to channel desensitization. Interactions between Nrf2-associated nutrients and TRPA1/TRPV1 may be partly responsible for the severity of some of the COVID-19 symptoms. The regulation by Nrf2 of TRPA1/TRPV1 is still unclear, but suggested from very limited clinical evidence. In COVID-19, it is proposed that rapid desensitization of TRAP1/TRPV1 by some ingredients in foods could reduce symptom severity and provide new therapeutic strategies.", "doi": "10.1159/000514204", "pmid": "33567446", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "000514204"}], "notes": [], "created": "2021-02-11T15:22:39.327Z", "modified": "2021-02-11T15:22:39.344Z"}, {"entity": "publication", "iuid": "d0fae14071314e24ad54e8a7ccb1440a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d0fae14071314e24ad54e8a7ccb1440a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d0fae14071314e24ad54e8a7ccb1440a"}}, "title": "Community health worker knowledge, attitudes and practices towards COVID-19: Learnings from an online cross-sectional survey using a digital health platform, UpSCALE, in Mozambique.", "authors": [{"family": "Feldman", "given": "Mitra", "initials": "M"}, {"family": "Lacey Krylova", "given": "Vera", "initials": "V"}, {"family": "Farrow", "given": "Poppy", "initials": "P"}, {"family": "Donovan", "given": "Laura", "initials": "L"}, {"family": "Zandamela", "given": "Edson", "initials": "E"}, {"family": "Rebelo", "given": "Joaquim", "initials": "J"}, {"family": "Rodrigues", "given": "Maria", "initials": "M"}, {"family": "Bulo", "given": "Antonio", "initials": "A"}, {"family": "Ferraz", "given": "Carlos", "initials": "C"}, {"family": "Rodrigues", "given": "Humberto", "initials": "H"}, {"family": "Roca-Feltrer", "given": "Arantxa", "initials": "A"}, {"family": "Baker", "given": "Kevin", "initials": "K"}], "type": "journal article", "published": "2021-02-10", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "2", "pages": "e0244924"}, "abstract": "Healthcare workers (HCWs) are at the frontline of the Coronavirus Disease 2019 (COVID-19) pandemic response, yet there is a paucity of literature on their knowledge, attitudes and practices (KAP) in relation to the pandemic. Community Health Workers (CHWs) in Mozambique are known locally as agentes polivalentes elementares (APEs). While technical guidance surrounding COVID-19 is available to support APEs, communicating this information has been challenging due to restrictions on travel, face-to-face group meetings and training, imposed from May to August 2020. A digital health platform, upSCALE, that already supports 1,213 APEs and 299 supervisors across three provinces, is being used to support APEs on effective COVID-19 management by delivering COVID-19 sensitive SMS messages, training modules and a COVID-19 KAP survey. The KAP survey, conducted from June 2020 to August 2020, consisted of 10 questions. Of 1,065 active upSCALE APEs, 28% completed the survey. Results indicate that only a small proportion of APEs listed the correct COVID-19 symptoms, transmission routes and appropriate prevention measures (n = (25%), n = (16%) and n = (39%), respectively) specifically included in national health education materials. Misconceptions were mainly related to transmission routes, high risk individuals and asymptomatic patients. 84% said they followed all government prevention guidelines. The results from the KAP survey were used to support the rapid development and deployment of targeted COVID-19 awareness and education materials for the APEs. A follow-up KAP survey is planned for November 2020. Adapting the existing upSCALE platform enabled a better understanding, in real time, of the KAP of APEs around COVID-19 management. Subsequently, supporting delivery of tailored messages and education, vital for ensuring a successful COVID-19 response.", "doi": "10.1371/journal.pone.0244924", "pmid": "33566850", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-32538"}, {"db": "URL", "key": "https://reshare.ukdataservice.ac.uk/854605/", "description": "The Covid-19 pandemic: knowledge, attitudes and practice among healthcare workers in Mozambique, Survey 1, 2020"}], "notes": [], "created": "2021-02-11T15:23:36.305Z", "modified": "2021-06-18T12:05:11.207Z"}, {"entity": "publication", "iuid": "badb217a9cb84081b47447b503898d2f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/badb217a9cb84081b47447b503898d2f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/badb217a9cb84081b47447b503898d2f"}}, "title": "Anticoagulation therapy in non-valvular atrial fibrillation in the COVID-19 era: is it time to reconsider our therapeutic strategy?", "authors": [{"family": "Papakonstantinou", "given": "Panteleimon E", "initials": "PE"}, {"family": "Borovac", "given": "Josip A", "initials": "JA"}, {"family": "G\u0105secka", "given": "Aleksandra", "initials": "A"}, {"family": "Bongiovanni", "given": "Dario", "initials": "D"}, {"family": "Ehrlinder", "given": "Hanne", "initials": "H"}, {"family": "Giustozzi", "given": "Michela", "initials": "M"}, {"family": "Parker", "given": "William A E", "initials": "WAE"}, {"family": "Guerreiro", "given": "Rui Azevedo", "initials": "RA"}], "type": "journal article", "published": "2021-02-10", "journal": {"title": "Eur J Prev Cardiol", "issn": "2047-4881", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1093/eurjpc/zwab021", "pmid": "33564838", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "6132124"}, {"db": "pmc", "key": "PMC7928961"}], "notes": [], "created": "2021-02-10T18:57:47.004Z", "modified": "2021-07-14T07:51:54.412Z"}, {"entity": "publication", "iuid": "f04b983482764324aa721d7822f04bc1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f04b983482764324aa721d7822f04bc1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f04b983482764324aa721d7822f04bc1"}}, "title": "A Case Series on Critically Ill Pregnant or Newly Delivered Patients with Covid-19, Treated at Karolinska University Hospital, Stockholm", "authors": [{"family": "Polcer", "given": "Rasha El ahmad", "initials": "REa"}, {"family": "Jones", "given": "Elin", "initials": "E"}, {"family": "Pettersson", "given": "Karin", "initials": "K"}], "type": "journal-article", "published": "2021-02-10", "journal": {"title": "Case Reports in Obstetrics and Gynecology", "issn": "2090-6692", "issn-l": null, "volume": "2021", "issue": null, "pages": "1-7"}, "abstract": "In this retrospective report, we present five cases of critically ill pregnant or newly delivered women positive for Covid-19 admitted to our obstetrical departments at Karolinska University Hospital. They compose 6% of eighty-three pregnant women that tested positive for SARS-CoV-2 during the period March 25 to May 4, 2020. Three patients were at the time of admission in gestational week between 21 + 4 and 22 + 5 and treated during their antenatal period; meanwhile, the other two were admitted within 1 week postpartum. All of them were in need of intensive care: one was treated with high flow oxygen therapy, the other four with invasive mechanical ventilation (three with endotracheal intubation and one with extracorporeal membrane oxygenation). Age above thirty, overweight, and gestational diabetes are notable factors in the cases presented. At the time of admission, they all presented with symptoms such as fever, cough, and dyspnea. Chest imaging with computer tomography scan was performed in each case and demonstrated multifocal pneumonic infiltrates in all of them, but no pulmonary embolism was confirmed in any. Neither did the echocardiogram indicate any cardiomyopathy. Four of the patients have been discharged from the hospital, with an average of 20 hospital days. One antenatal pregnant woman needed prolonged ECMO therapy; in gestational week 27 + 3, she went into cardiac arrest, resulting in an urgent C-section on maternal indication. At the time of writing, she is still hospitalized. In coherence with other published reports, our cases indicate that critically ill pregnant women infected by SARS-Cov-2 may develop severe respiratory distress syndrome requiring prolonged intensive care. The material is limited for conclusions to be made; more detailed information on symptoms, treatment, and outcomes for pregnant and postpartum women managed in intensive care is therefore needed.", "doi": "10.1155/2021/8868822", "pmid": "33628548", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-25T12:31:56.276Z", "modified": "2021-06-18T11:42:21.196Z"}, {"entity": "publication", "iuid": "77f938e81f1d4b39b6265fbea9bfe0b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/77f938e81f1d4b39b6265fbea9bfe0b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/77f938e81f1d4b39b6265fbea9bfe0b2"}}, "title": "\"People play it down and tell me it can't kill people, but I know people are dying each day\". Children's health literacy relating to a global pandemic (COVID-19); an international cross sectional study.", "authors": [{"family": "Bray", "given": "Lucy", "initials": "L"}, {"family": "Carter", "given": "Bernie", "initials": "B"}, {"family": "Blake", "given": "Lucy", "initials": "L"}, {"family": "Saron", "given": "Holly", "initials": "H"}, {"family": "Kirton", "given": "Jennifer A", "initials": "JA"}, {"family": "Robichaud", "given": "Fanny", "initials": "F"}, {"family": "Avila", "given": "Marla", "initials": "M"}, {"family": "Ford", "given": "Karen", "initials": "K"}, {"family": "Nafria", "given": "Begonya", "initials": "B"}, {"family": "Forsner", "given": "Maria", "initials": "M"}, {"family": "Nilsson", "given": "Stefan", "initials": "S"}, {"family": "Chelkowski", "given": "Andrea", "initials": "A"}, {"family": "Middleton", "given": "Andrea", "initials": "A"}, {"family": "Rullander", "given": "Anna-Clara", "initials": "A"}, {"family": "Mattsson", "given": "Janet", "initials": "J"}, {"family": "Protheroe", "given": "Joanne", "initials": "J"}], "type": "journal article", "published": "2021-02-10", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "2", "pages": "e0246405"}, "abstract": "The aim of this study was to examine aspects of children's health literacy; the information sources they were accessing, their information preferences, their perceived understanding of and their reported information needs in relation to COVID-19. An online survey for children aged 7-12 years of age and parent/caregivers from the UK, Sweden, Brazil, Spain, Canada and Australia was conducted between 6th of April and the 1st of June 2020. The surveys included demographic questions and both closed and open questions focussing on access to and understanding of COVID-19 information. Descriptive statistics and qualitative content analysis procedures were conducted. The findings show that parents are the main source of information for children during the pandemic in most countries (89%, n = 347), except in Sweden where school was the main source of information. However, in many cases parents chose to shield, filter or adapt their child's access to information about COVID-19, especially in relation to the death rates within each country. Despite this, children in this study reported knowing that COVID-19 was deadly and spreads quickly. This paper argues for a community rather than individual approach to addressing children's health literacy needs during a pandemic.", "doi": "10.1371/journal.pone.0246405", "pmid": "33566813", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-19761"}], "notes": [], "created": "2021-02-11T15:29:29.582Z", "modified": "2021-06-18T12:06:38.023Z"}, {"entity": "publication", "iuid": "7278e8eb255248eb836f6d82888ae39c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7278e8eb255248eb836f6d82888ae39c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7278e8eb255248eb836f6d82888ae39c"}}, "title": "The development of preprints during the COVID-19 pandemic.", "authors": [{"family": "\u00c4lg\u00e5", "given": "Andreas", "initials": "A"}, {"family": "Eriksson", "given": "Oskar", "initials": "O"}, {"family": "Nordberg", "given": "Martin", "initials": "M"}], "type": "editorial", "published": "2021-02-09", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1111/joim.13240", "pmid": "33560546", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-10T18:59:52.815Z", "modified": "2021-02-10T18:59:52.826Z"}, {"entity": "publication", "iuid": "536b0c5204ee49c280d9f4d8249a56a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/536b0c5204ee49c280d9f4d8249a56a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/536b0c5204ee49c280d9f4d8249a56a2"}}, "title": "Sustained prothrombotic changes in COVID-19 patients 4 months after hospital discharge.", "authors": [{"family": "von Meijenfeldt", "given": "Fien A", "initials": "FA"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Adelmeijer", "given": "Jelle", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Thalin", "given": "Charlotte", "initials": "C"}, {"family": "Lisman", "given": "Ton", "initials": "T"}], "type": "journal article", "published": "2021-02-09", "journal": {"title": "Blood Adv", "issn": "2473-9537", "issn-l": null, "volume": "5", "issue": "3", "pages": "756-759"}, "abstract": null, "doi": "10.1182/bloodadvances.2020003968", "pmid": "33560386", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "475081"}], "notes": [], "created": "2021-02-10T18:46:05.850Z", "modified": "2021-06-11T14:26:07.518Z"}, {"entity": "publication", "iuid": "2b9f338fa3e240a480a9162feedee0b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b9f338fa3e240a480a9162feedee0b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b9f338fa3e240a480a9162feedee0b9"}}, "title": "Handwashing with soap: A concern for overuse of water amidst the COVID-19 pandemic in Bangladesh.", "authors": [{"family": "Sayeed", "given": "Abu", "initials": "A"}, {"family": "Rahman", "given": "Md Hafizur", "initials": "MH"}, {"family": "Bundschuh", "given": "Jochen", "initials": "J"}, {"family": "Herath", "given": "Indika", "initials": "I"}, {"family": "Ahmed", "given": "Fahad", "initials": "F"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Tariq", "given": "Mohammad Raihan", "initials": "MR"}, {"family": "Rahman", "given": "Faujhia", "initials": "F"}, {"family": "Tarikul Islam Joy", "given": "Md", "initials": "M"}, {"family": "Tazrian Abid", "given": "Mohammad", "initials": "M"}, {"family": "Saha", "given": "Nondo", "initials": "N"}, {"family": "Hasan", "given": "M Tasdik", "initials": "MT"}], "type": "journal article", "published": "2021-02-09", "journal": {"title": "Groundw Sustain Dev", "issn": "2352-801X", "volume": "13", "issue": null, "pages": "100561", "issn-l": null}, "abstract": "Handwashing is one of the vital public health measures. It helps to prevent the spread of the COVID-19 pandemic. However, water overuse during hand scrubbing with soap keeping the tap on may put enormous pressure on the already overstretched groundwater resources and households' economic well-being. Therefore, this study aimed to determine the overuse of water while scrubbing hands with soap for handwashing when the tap is on amid the COVID-19 pandemic in Bangladesh. Sociodemographic data were collected using a web-based survey tool among 1980 participants and an experiment was conducted among 126 participants to estimate the overuse of water during hand scrubbing while the tap is on. A total of 80% of the participants washed their hands regularly after returning home from outside. About 57.27% of participants did not turn off their tap throughout the handwashing process. A single participant, who kept his tap on throughout the handwashing process, overused approximately 1.7L of water per handwash and 14.9L of water per day. Hand scrubbing with soap keeping the tap on, raised the overuse of water 13-fold during this pandemic compared to the non-pandemic situation which cost an extra 224.95 BDT (2.65$) per day for 1980 participants. Minimize the speed of tap, using automatic taps, and using taps operated by legs might be an effective solution to reduce the water overuse. Furthermore, behavioral change interventions are needed to aware people turn off the tap during hand scrubbing with soap.", "doi": "10.1016/j.gsd.2021.100561", "pmid": "33585670", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2352-801X(21)00017-5"}, {"db": "pmc", "key": "PMC7871103"}], "notes": [], "created": "2021-02-17T14:50:24.246Z", "modified": "2021-03-22T11:42:49.287Z"}, {"entity": "publication", "iuid": "e562fc74663e4915acbb53b5738d65a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e562fc74663e4915acbb53b5738d65a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e562fc74663e4915acbb53b5738d65a4"}}, "title": "First detection of SARS-CoV-2 genetic material in the vicinity of COVID-19 isolation Centre in Bangladesh: Variation along the sewer network.", "authors": [{"family": "Ahmed", "given": "Firoz", "initials": "F"}, {"family": "Islam", "given": "Md Aminul", "initials": "MA"}, {"family": "Kumar", "given": "Manish", "initials": "M"}, {"family": "Hossain", "given": "Maqsud", "initials": "M"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Islam", "given": "Md Tahmidul", "initials": "MT"}, {"family": "Hossen", "given": "Foysal", "initials": "F"}, {"family": "Hossain", "given": "Md Shahadat", "initials": "MS"}, {"family": "Islam", "given": "Md Sydul", "initials": "MS"}, {"family": "Uddin", "given": "Md Main", "initials": "MM"}, {"family": "Islam", "given": "Md Nur", "initials": "MN"}, {"family": "Bahadur", "given": "Newaz Mohammed", "initials": "NM"}, {"family": "Didar-Ul-Alam", "given": "Md", "initials": "M"}, {"family": "Reza", "given": "Hasan Mahmud", "initials": "HM"}, {"family": "Jakariya", "given": "Md", "initials": "M"}], "type": "journal article", "published": "2021-02-09", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "volume": "776", "issue": null, "pages": "145724", "issn-l": "0048-9697"}, "abstract": "We made the first and successful attempt to detect SARS-CoV-2 genetic material in the vicinity wastewaters of an isolation centre i.e. Shaheed Bhulu Stadium, situated at Noakhali, Southeastern Bangladesh. Owing to the fact that isolation centre, in general, always contained a constant number of 200 COVID-19 patients, the prime objective of the study was to check if several drains carrying RNA of coronavirus are actually getting diluted or accumulated along with the sewage network. Our finding suggested that while the temporal variation of the genetic load decreased in small drains over the span of 50 days, the main sewer exhibited accumulation of SARS-CoV-2 RNA. Other interesting finding displays that probably distance of sampling location in meters is not likely to have a significant impact on the detected gene concentration, although the quantity of the RNA extracted in the downstream of the drain was higher. These findings are of immense value from the perspective of wastewater surveillance of COVID-19, as they largely imply that we do not need to monitor every wastewater system, and probably major drains monitoring may illustrate the city health. Perhaps, we are reporting the accumulation of SARS-CoV-2 genetic material along with the sewer network i.e. from primary to tertiary drains. The study sought further data collection in this line to simulate conditions prevailed in most of the developing countries and to shed further light on decay/accumulation processes of the genetic load of the SARS-COV-2.", "doi": "10.1016/j.scitotenv.2021.145724", "pmid": "33652314", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(21)00791-9"}], "notes": [], "created": "2021-03-03T17:01:46.916Z", "modified": "2021-03-03T17:01:46.926Z"}, {"entity": "publication", "iuid": "b9bc34b1d45246a19d2d3aff1df7c606", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9bc34b1d45246a19d2d3aff1df7c606.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9bc34b1d45246a19d2d3aff1df7c606"}}, "title": "COVID-19 vaccines and kidney disease.", "authors": [{"family": "Windpessl", "given": "Martin", "initials": "M"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Anders", "given": "Hans-Joachim", "initials": "HJ"}, {"family": "Kramer", "given": "Holly", "initials": "H"}, {"family": "Waldman", "given": "Meryl", "initials": "M"}, {"family": "Renia", "given": "Laurent", "initials": "L"}, {"family": "Ng", "given": "Lisa F P", "initials": "LFP"}, {"family": "Xing", "given": "Zhou", "initials": "Z"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2021-02-08", "journal": {"title": "Nat Rev Nephrol", "issn": "1759-507X", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1038/s41581-021-00406-6", "pmid": "33558753", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41581-021-00406-6"}], "notes": [], "created": "2021-02-10T18:47:05.964Z", "modified": "2021-02-10T18:47:05.975Z"}, {"entity": "publication", "iuid": "57df1c32e6104e6b9634fabdc4d27b9b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/57df1c32e6104e6b9634fabdc4d27b9b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/57df1c32e6104e6b9634fabdc4d27b9b"}}, "title": "Studying Gambling Behaviors and Responsible Gambling Tools in a Simulated Online Casino Integrated With Amazon Mechanical Turk: Development and Initial Validation of Survey Data and Platform Mechanics of the Frescati Online Research Casino", "authors": [{"family": "Lindner", "given": "Philip", "initials": "P"}, {"family": "Ramner\u00f6", "given": "Jonas", "initials": "J"}, {"family": "Ivanova", "given": "Ekaterina", "initials": "E"}, {"family": "Carlbring", "given": "Per", "initials": "P"}], "type": "journal-article", "published": "2021-02-05", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "issn-l": "1664-0640", "volume": "11", "issue": null, "pages": null}, "abstract": null, "doi": "10.3389/fpsyt.2020.571954", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-22T14:07:06.763Z", "modified": "2021-02-26T08:46:59.959Z"}, {"entity": "publication", "iuid": "cfe8ca6f92bd43ca9beba7c1fd0ed82b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfe8ca6f92bd43ca9beba7c1fd0ed82b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfe8ca6f92bd43ca9beba7c1fd0ed82b"}}, "title": "Family Transmission of COVID-19 Including a Child with MIS-C and Acute Pancreatitis.", "authors": [{"family": "Abbas", "given": "Maher", "initials": "M"}, {"family": "T\u00f6rnhage", "given": "Carl-Johan", "initials": "C"}], "type": "case reports", "published": "2021-02-05", "journal": {"title": "Int Med Case Rep J", "issn": "1179-142X", "issn-l": null, "volume": "14", "issue": null, "pages": "55-65"}, "abstract": "Spread of the novel coronavirus SARS-CoV-2, since at least December 2019, has caused a pandemic. SARS-CoV-2 causes the disease COVID-19, which can affect several human organs. Abdominal pain is one of the known symptoms, but little is known about acute pancreatitis as a complication. As well, knowledge about viral transmission in families is limited. This case report describes MIS-C and acalculous acute pancreatitis in a child who was a member of a family in which four of five members had COVID-19.\r\n\r\nA previously healthy family was infected by SARS-CoV-2 from an unknown source. The 13-year-old daughter was infected by SARS-CoV-2 and symptomatic during two periods, with an asymptomatic interval in-between. During the first period, she had transient and mild upper respiratory symptoms which was followed four weeks later by a secondary severe illness. At that point, there was inflammation in multiple organs and signs of Multisystem Inflammatory Syndrome in Children (MIS-C) and a Kawasaki-like disease with skin rash, scalded skin in hands and conjunctivitis. Myocarditis, bronchopneumonia, pancreatitis, and hepatopathy without encephalopathy were noted. She required assisted ventilation for 5 days. There were laboratory signs of disseminated intravascular coagulopathy. The multisystem inflammation was treated with intravenous immunoglobulin (IVIG) once a day for four days and immunotherapy (high dose methylprednisolone (IV) once a day, for 12 days, then tapered over 4 weeks, anakinra (IV) four times daily for 12 days), low molecular weight heparin for 22 days and salicylates for 6 weeks leading to full restoration of health. The two brothers and mother in the family had mild to moderate COVID-19 infections. The father was not affected despite close contact with his children. The household transmission and clinical course and outcome are described. No further known COVID-19 infection occurred in the neighborhood during or immediately after the family cluster was discovered.\r\n\r\nPenetrance and severity of COVID-19 can vary in family clusters. One adolescent showed a two-phase course with severe infection. This case report highlights MIS-C and acute pancreatitis as a complication associated with COVID-19 in children.", "doi": "10.2147/IMCRJ.S284480", "pmid": "33574714", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "284480"}, {"db": "pmc", "key": "PMC7872935"}], "notes": [], "created": "2021-02-15T12:55:45.375Z", "modified": "2021-06-18T11:40:22.589Z"}, {"entity": "publication", "iuid": "b4d9a71a5e6d4e88930986beffc8b7d8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b4d9a71a5e6d4e88930986beffc8b7d8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b4d9a71a5e6d4e88930986beffc8b7d8"}}, "title": "Efficacy and tolerability of bevacizumab in patients with severe Covid-19.", "authors": [{"family": "Pang", "given": "Jiaojiao", "initials": "J", "orcid": "0000-0003-0072-3703", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb34db1aeb5f4f2391db995b579ea6ea.json"}}, {"family": "Xu", "given": "Feng", "initials": "F", "orcid": "0000-0002-4670-3727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/498adee7663c41338b60b0b778220c74.json"}}, {"family": "Aondio", "given": "Gianmarco", "initials": "G"}, {"family": "Li", "given": "Yu", "initials": "Y", "orcid": "0000-0003-4798-1638", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4f22daad666482fa488f4ce3e61d529.json"}}, {"family": "Fumagalli", "given": "Alberto", "initials": "A", "orcid": "0000-0002-7126-2337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d45660687d943c692306180fa66ab53.json"}}, {"family": "Lu", "given": "Ming", "initials": "M", "orcid": "0000-0002-8685-6322", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fce9ebd8f3c04405b9f596909fd01d16.json"}}, {"family": "Valmadre", "given": "Giuseppe", "initials": "G"}, {"family": "Wei", "given": "Jie", "initials": "J"}, {"family": "Bian", "given": "Yuan", "initials": "Y", "orcid": "0000-0001-8559-2575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/756cab44ecb54bb9a627776894d99981.json"}}, {"family": "Canesi", "given": "Margherita", "initials": "M"}, {"family": "Damiani", "given": "Giovanni", "initials": "G", "orcid": "0000-0003-1736-9480", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00a2feef9a8a4fd28bd5edb74ab4935d.json"}}, {"family": "Zhang", "given": "Yuan", "initials": "Y", "orcid": "0000-0003-1052-2286", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab7225c5de0247e8b675a1099dae61b2.json"}}, {"family": "Yu", "given": "Dexin", "initials": "D", "orcid": "0000-0001-7462-3153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/febf345d28374bf49009cb2a2d0cd5b8.json"}}, {"family": "Chen", "given": "Jun", "initials": "J", "orcid": "0000-0002-4865-9977", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad80138669a240f8bd11e1502ba55539.json"}}, {"family": "Ji", "given": "Xiang", "initials": "X"}, {"family": "Sui", "given": "Wenhai", "initials": "W", "orcid": "0000-0001-6114-0443", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79e84ee2d66c4463a20ced8545e4f7c1.json"}}, {"family": "Wang", "given": "Bailu", "initials": "B", "orcid": "0000-0002-5420-9569", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceefa93c6e3e4f2fb606d20435630b3c.json"}}, {"family": "Wu", "given": "Shuo", "initials": "S", "orcid": "0000-0003-3684-4363", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/502c977738674afc94abc7866b5acb65.json"}}, {"family": "Kovacs", "given": "Attila", "initials": "A"}, {"family": "Revera", "given": "Miriam", "initials": "M"}, {"family": "Wang", "given": "Hao", "initials": "H", "orcid": "0000-0003-4493-3147", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4fdb7f4d1b04a5dae7c2ce062117149.json"}}, {"family": "Jing", "given": "Xu", "initials": "X"}, {"family": "Zhang", "given": "Ying", "initials": "Y", "orcid": "0000-0003-1052-2286", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab7225c5de0247e8b675a1099dae61b2.json"}}, {"family": "Chen", "given": "Yuguo", "initials": "Y", "orcid": "0000-0001-9501-2546", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2960cdc067cd4ee7ad01f08951fe6e15.json"}}, {"family": "Cao", "given": "Yihai", "initials": "Y", "orcid": "0000-0003-1308-0065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e94efe139da46f3888539ccf8c6d6cf.json"}}], "type": "clinical trial", "published": "2021-02-05", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "814"}, "abstract": "On the basis of Covid-19-induced pulmonary pathological and vascular changes, we hypothesize that the anti-vascular endothelial growth factor (VEGF) drug bevacizumab might be beneficial for treating Covid-19 patients. From Feb 15 to April 5, 2020, we conducted a single-arm trial (NCT04275414) and recruited 26 patients from 2-centers (China and Italy) with severe Covid-19, with respiratory rate \u226530 times/min, oxygen saturation \u226493% with ambient air, or partial arterial oxygen pressure to fraction of inspiration O2 ratio (PaO2/FiO2) >100 mmHg and \u2264300 mmHg, and diffuse pneumonia confirmed by chest imaging. Followed up for 28 days. Among these, bevacizumab plus standard care markedly improves the PaO2/FiO2 ratios at days 1 and 7. By day 28, 24 (92%) patients show improvement in oxygen-support status, 17 (65%) patients are discharged, and none show worsen oxygen-support status nor die. Significant reduction of lesion areas/ratios are shown in chest computed tomography (CT) or X-ray within 7 days. Of 14 patients with fever, body temperature normalizes within 72 h in 13 (93%) patients. Relative to comparable controls, bevacizumab shows clinical efficacy by improving oxygenation and shortening oxygen-support duration. Our findings suggest bevacizumab plus standard care is highly beneficial for patients with severe Covid-19. Randomized controlled trial is warranted.", "doi": "10.1038/s41467-021-21085-8", "pmid": "33547300", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC7864918"}, {"db": "pii", "key": "10.1038/s41467-021-21085-8"}, {"db": "ClinicalTrials.gov", "key": "NCT04275414"}, {"db": "figshare", "key": "10.6084/m9.figshare.13482810"}, {"db": "figshare", "key": "10.6084/m9.figshare.13482834"}], "notes": [], "created": "2021-02-05T11:00:55.502Z", "modified": "2023-06-19T14:36:24.662Z"}, {"entity": "publication", "iuid": "95af2e1173584d369a02dd581c426f45", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95af2e1173584d369a02dd581c426f45.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95af2e1173584d369a02dd581c426f45"}}, "title": "The impact of COVID-19 on oncology professionals: results of the ESMO Resilience Task Force survey collaboration.", "authors": [{"family": "Banerjee", "given": "S", "initials": "S"}, {"family": "Lim", "given": "K H J", "initials": "KHJ"}, {"family": "Murali", "given": "K", "initials": "K"}, {"family": "Kamposioras", "given": "K", "initials": "K"}, {"family": "Punie", "given": "K", "initials": "K"}, {"family": "Oing", "given": "C", "initials": "C"}, {"family": "O'Connor", "given": "M", "initials": "M"}, {"family": "Thorne", "given": "E", "initials": "E"}, {"family": "Devnani", "given": "B", "initials": "B"}, {"family": "Lambertini", "given": "M", "initials": "M"}, {"family": "Westphalen", "given": "C B", "initials": "CB"}, {"family": "Garrido", "given": "P", "initials": "P"}, {"family": "Amaral", "given": "T", "initials": "T"}, {"family": "Morgan", "given": "G", "initials": "G"}, {"family": "Haanen", "given": "J B A G", "initials": "JBAG"}, {"family": "Hardy", "given": "C", "initials": "C"}], "type": "journal article", "published": "2021-02-04", "journal": {"title": "ESMO Open", "issn": "2059-7029", "issn-l": null, "volume": "6", "issue": "2", "pages": "100058"}, "abstract": "The impact of the coronavirus disease 2019 (COVID-19) pandemic on well-being has the potential for serious negative consequences on work, home life, and patient care. The European Society for Medical Oncology (ESMO) Resilience Task Force collaboration set out to investigate well-being in oncology over time since COVID-19.\r\n\r\nTwo online anonymous surveys were conducted (survey I: April/May 2020; survey II: July/August 2020). Statistical analyses were performed to examine group differences, associations, and predictors of key outcomes: (i) well-being/distress [expanded Well-being Index (eWBI; 9 items)]; (ii) burnout (1 item from eWBI); (iii) job performance since COVID-19 (JP-CV; 2 items).\r\n\r\nResponses from survey I (1520 participants from 101 countries) indicate that COVID-19 is impacting oncology professionals; in particular, 25% of participants indicated being at risk of distress (poor well-being, eWBI \u2265 4), 38% reported feeling burnout, and 66% reported not being able to perform their job compared with the pre-COVID-19 period. Higher JP-CV was associated with better well-being and not feeling burnout (P < 0.01). Differences were seen in well-being and JP-CV between countries (P < 0.001) and were related to country COVID-19 crude mortality rate (P < 0.05). Consistent predictors of well-being, burnout, and JP-CV were psychological resilience and changes to work hours. In survey II, among 272 participants who completed both surveys, while JP-CV improved (38% versus 54%, P < 0.001), eWBI scores \u22654 and burnout rates were significantly higher compared with survey I (22% versus 31%, P = 0.01; and 35% versus 49%, P = 0.001, respectively), suggesting well-being and burnout have worsened over a 3-month period during the COVID-19 pandemic.\r\n\r\nIn the first and largest global survey series, COVID-19 is impacting well-being and job performance of oncology professionals. JP-CV has improved but risk of distress and burnout has increased over time. Urgent measures to address well-being and improve resilience are essential.", "doi": "10.1016/j.esmoop.2021.100058", "pmid": "33601295", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2059-7029(21)00013-2"}], "notes": [], "created": "2021-02-19T14:07:28.255Z", "modified": "2021-06-18T11:32:37.310Z"}, {"entity": "publication", "iuid": "9289ed9c644f4e02942703bee07dda08", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9289ed9c644f4e02942703bee07dda08.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9289ed9c644f4e02942703bee07dda08"}}, "title": "DNA-launched RNA replicon vaccines induce potent anti-SARS-CoV-2 immune responses in mice", "authors": [{"family": "Szurgot", "given": "Inga", "initials": "I"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Vidakovics", "given": "Laura Perez", "initials": "LP"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}, {"family": "Liljestr\u00f6m", "given": "Peter", "initials": "P"}], "type": "journal-article", "published": "2021-02-04", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "3125"}, "abstract": "The outbreak of the SARS-CoV-2 virus and its rapid spread into a global pandemic made the urgent development of scalable vaccines to prevent coronavirus disease (COVID-19) a global health and economic imperative. Here, we characterized and compared the immunogenicity of two alphavirus-based DNA-launched self-replicating (DREP) vaccine candidates encoding either SARS-CoV-2 spike glycoprotein (DREP-S) or a spike ectodomain trimer stabilized in prefusion conformation (DREP-S ecto). We observed that the two DREP constructs were immunogenic in mice inducing both binding and neutralizing antibodies as well as T cell responses. Interestingly, the DREP coding for the unmodified spike turned out to be more potent vaccine candidate, eliciting high titers of SARS-CoV-2 specific IgG antibodies that were able to efficiently neutralize pseudotyped virus after a single immunization. In addition, both DREP constructs were able to efficiently prime responses that could be boosted with a heterologous spike protein immunization. These data provide important novel insights into SARS-CoV-2 vaccine design using a rapid response DNA vaccine platform. Moreover, they encourage the use of mixed vaccine modalities as a strategy to combat SARS-CoV-2.", "doi": "10.1038/s41598-021-82498-5", "pmid": "33542325", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Drug Discovery": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-02-04T20:58:59.276Z", "modified": "2021-12-07T15:32:28.810Z"}, {"entity": "publication", "iuid": "c14184ccb8cd435ca5b458a45a37aa30", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c14184ccb8cd435ca5b458a45a37aa30.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c14184ccb8cd435ca5b458a45a37aa30"}}, "title": "The male disadvantage in life expectancy: can we close the gender gap?", "authors": [{"family": "Hossin", "given": "Muhammad Zakir", "initials": "MZ"}], "type": "journal-article", "published": "2021-02-03", "journal": {"title": "Int Health", "issn": "1876-3405", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Men are usually considered to be the stronger sex. However, when it comes to health, they are evidently weaker than their female counterparts. In almost all countries around the world, men consistently live shorter lives than women. The gender gap in longevity has once again been evident during the ongoing coronavirus disease 2019 (COVID-19) pandemic, which kills men disproportionately. Drawing on the relevant scientific literature and updated information, this article aimed to provide useful insights into the biological and social mechanisms that potentially underlie the gender gap in life expectancy.", "doi": "10.1093/inthealth/ihaa106", "pmid": "33533409", "labels": {"Type: Other": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6127106"}], "notes": [], "created": "2021-02-04T18:12:38.304Z", "modified": "2021-06-18T11:21:35.267Z"}, {"entity": "publication", "iuid": "f9a0683bd2434fbdafbc5b3ab6408805", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f9a0683bd2434fbdafbc5b3ab6408805.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f9a0683bd2434fbdafbc5b3ab6408805"}}, "title": "Differential expression of Angiotensin-Converting Enzyme 2 in Nasal Tissue of Patients with Chronic Rhinosinusitis with Nasal Polyps", "authors": [{"family": "Fowler", "given": "Philippa C", "initials": "PC"}, {"family": "Naluai", "given": "\u00c5sa Torinsson", "initials": "\u00c5T"}, {"family": "Oscarsson", "given": "Martin", "initials": "M"}, {"family": "Torkzadeh", "given": "Sara", "initials": "S"}, {"family": "Bohman", "given": "Anton", "initials": "A"}, {"family": "Bende", "given": "Mats", "initials": "M"}, {"family": "Harandi", "given": "Ali M", "initials": "AM"}], "type": "posted-content", "published": "2021-02-03", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.01.21250623", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-02-11T15:43:20.813Z", "modified": "2021-06-17T08:02:05.809Z"}, {"entity": "publication", "iuid": "673c6de5246548888c52474ae57417cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/673c6de5246548888c52474ae57417cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/673c6de5246548888c52474ae57417cc"}}, "title": "COVID-19 Herd Immunity in the Absence of a Vaccine: An Irresponsible Approach.", "authors": [{"family": "Khalife", "given": "Jade", "initials": "J"}, {"family": "VanGennep", "given": "Derrick", "initials": "D"}], "type": "journal article", "published": "2021-02-03", "journal": {"title": "Epidemiol Health", "issn": "2092-7193", "volume": null, "issue": null, "pages": "e2021012", "issn-l": null}, "abstract": "With SARS-CoV-2 continuing to spread rapidly throughout the human population, the concept of 'herd immunity' has been attracting the attention of both decision makers and the general public. In the absence of a vaccine, this entails that a large proportion of the population be infected to develop immunity that would limit the severity and/or extent of subsequent outbreaks. We argue that adopting such an approach should be avoided for several reasons: There are significant uncertainties about whether achieving herd immunity is possible. If possible, achieving herd immunity would impose a large burden on society. There are gaps in protection, making it difficult to shield the vulnerable. It would defeat the purpose of avoiding harm caused by the virus. Lastly, dozens of countries are showing that containment is possible.", "doi": "10.4178/epih.e2021012", "pmid": "33541010", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "epih.e2021012"}], "notes": [], "created": "2021-02-05T11:29:57.851Z", "modified": "2021-02-05T11:29:57.876Z"}, {"entity": "publication", "iuid": "82ee9b48aa8b42e2a02f0d191c2674af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82ee9b48aa8b42e2a02f0d191c2674af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82ee9b48aa8b42e2a02f0d191c2674af"}}, "title": "The international Perinatal Outcomes in the Pandemic (iPOP) study: protocol.", "authors": [{"family": "Stock", "given": "Sarah J", "initials": "SJ", "orcid": "0000-0003-4308-856X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c04f8cfa9161491eb157b1bea4cc8a6a.json"}}, {"family": "Zoega", "given": "Helga", "initials": "H", "orcid": "0000-0003-0761-9028", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52887f3b5931453494a3416c0b97ce9b.json"}}, {"family": "Brockway", "given": "Meredith", "initials": "M"}, {"family": "Mulholland", "given": "Rachel H", "initials": "RH"}, {"family": "Miller", "given": "Jessica E", "initials": "JE", "orcid": "0000-0002-1806-1894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d973c66d5b5c4f779651915daa7b305c.json"}}, {"family": "Been", "given": "Jasper V", "initials": "JV", "orcid": "0000-0002-4907-6466", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27a8e734cc6a49f6ba5f9f25dc6f4235.json"}}, {"family": "Wood", "given": "Rachael", "initials": "R", "orcid": "0000-0003-4453-623X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cffadf504ae4f9eac53cdc2a00ffb8a.json"}}, {"family": "Abok", "given": "Ishaya I", "initials": "II"}, {"family": "Alshaikh", "given": "Belal", "initials": "B", "orcid": "0000-0002-6080-6888", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4fd691f58969420c9695cfc7645f8d31.json"}}, {"family": "Ayede", "given": "Adejumoke I", "initials": "AI"}, {"family": "Bacchini", "given": "Fabiana", "initials": "F", "orcid": "0000-0003-4343-774X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3722ddcfd11442d68ba7c8fb79abd694.json"}}, {"family": "Bhutta", "given": "Zulfiqar A", "initials": "ZA"}, {"family": "Brew", "given": "Bronwyn K", "initials": "BK"}, {"family": "Brook", "given": "Jeffrey", "initials": "J"}, {"family": "Calvert", "given": "Clara", "initials": "C"}, {"family": "Campbell-Yeo", "given": "Marsha", "initials": "M", "orcid": "0000-0001-6645-2809", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3004a18f0ace4dbb8d828698c2123337.json"}}, {"family": "Chan", "given": "Deborah", "initials": "D"}, {"family": "Chirombo", "given": "James", "initials": "J", "orcid": "0000-0003-3132-3710", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebca6beba4e44841be3edf1f15431ca6.json"}}, {"family": "Connor", "given": "Kristin L", "initials": "KL"}, {"family": "Daly", "given": "Mandy", "initials": "M", "orcid": "0000-0001-7539-4874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10829e2a02064b19a2472c5c82c2bf0e.json"}}, {"family": "Einarsd\u00f3ttir", "given": "Kristjana", "initials": "K", "orcid": "0000-0003-4931-7650", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b9f81f471fa43c2a372d34651f0c64e.json"}}, {"family": "Fantasia", "given": "Ilaria", "initials": "I"}, {"family": "Franklin", "given": "Meredith", "initials": "M"}, {"family": "Fraser", "given": "Abigail", "initials": "A", "orcid": "0000-0002-7741-9470", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f1caaab396a4cf1a2b2e6f9f4442684.json"}}, {"family": "H\u00e5berg", "given": "Siri Eldevik", "initials": "SE"}, {"family": "Hui", "given": "Lisa", "initials": "L"}, {"family": "Huicho", "given": "Luis", "initials": "L"}, {"family": "Magnus", "given": "Maria C", "initials": "MC", "orcid": "0000-0002-0568-3774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3530918cfd534021a45a80628c89c580.json"}}, {"family": "Morris", "given": "Andrew D", "initials": "AD"}, {"family": "Nagy-Bonnard", "given": "Livia", "initials": "L"}, {"family": "Nassar", "given": "Natasha", "initials": "N"}, {"family": "Nyadanu", "given": "Sylvester Dodzi", "initials": "SD"}, {"family": "Iyabode Olabisi", "given": "Dedeke", "initials": "D"}, {"family": "Palmer", "given": "Kirsten R", "initials": "KR"}, {"family": "Pedersen", "given": "Lars Henning", "initials": "LH", "orcid": "0000-0001-6726-1991", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1ad7974d474490db8e59e0211b560d7.json"}}, {"family": "Pereira", "given": "Gavin", "initials": "G"}, {"family": "Racine-Poon", "given": "Amy", "initials": "A"}, {"family": "Ranger", "given": "Manon", "initials": "M", "orcid": "0000-0001-8253-0686", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73deca7ec726431085d33dc7edcf8435.json"}}, {"family": "Rihs", "given": "Tonia", "initials": "T"}, {"family": "Saner", "given": "Christoph", "initials": "C", "orcid": "0000-0003-1380-0341", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e95e43b46b343fab9da330d1ab34bed.json"}}, {"family": "Sheikh", "given": "Aziz", "initials": "A", "orcid": "0000-0001-7022-3056", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82e1b46e1bd74c51a84294d5fe0326da.json"}}, {"family": "Swift", "given": "Emma M", "initials": "EM", "orcid": "0000-0001-9476-130X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b583b9bece114d069a239a41813e68f1.json"}}, {"family": "Tooke", "given": "Lloyd", "initials": "L"}, {"family": "Urquia", "given": "Marcelo L", "initials": "ML"}, {"family": "Whitehead", "given": "Clare", "initials": "C", "orcid": "0000-0001-8267-1630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2aaf1b678b3e44f2bc9224e29198ee05.json"}}, {"family": "Yilgwan", "given": "Christopher", "initials": "C", "orcid": "0000-0003-4741-7009", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2610d1daa034c88818778cf507e7dfe.json"}}, {"family": "Rodriguez", "given": "Natalie", "initials": "N"}, {"family": "Burgner", "given": "David", "initials": "D", "orcid": "0000-0002-8304-4302", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/300873d0d8e6457487f9d120f43ecd75.json"}}, {"family": "Azad", "given": "Meghan B", "initials": "MB", "orcid": "0000-0002-5942-4444", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/283604a1391c483f931b22e45f7a7edb.json"}}, {"family": "iPOP Study Team", "given": "", "initials": ""}], "type": "journal article", "published": "2021-02-02", "journal": {"title": "Wellcome Open Res", "issn": "2398-502X", "volume": "6", "pages": "21", "issn-l": null}, "abstract": "Preterm birth is the leading cause of infant death worldwide, but the causes of preterm birth are largely unknown. During the early COVID-19 lockdowns, dramatic reductions in preterm birth were reported; however, these trends may be offset by increases in stillbirth rates. It is important to study these trends globally as the pandemic continues, and to understand the underlying cause(s). Lockdowns have dramatically impacted maternal workload, access to healthcare, hygiene practices, and air pollution - all of which could impact perinatal outcomes and might affect pregnant women differently in different regions of the world. In the international Perinatal Outcomes in the Pandemic (iPOP) Study, we will seize the unique opportunity offered by the COVID-19 pandemic to answer urgent questions about perinatal health. In the first two study phases, we will use population-based aggregate data and standardized outcome definitions to: 1) Determine rates of preterm birth, low birth weight, and stillbirth and describe changes during lockdowns; and assess if these changes are consistent globally, or differ by region and income setting, 2) Determine if the magnitude of changes in adverse perinatal outcomes during lockdown are modified by regional differences in COVID-19 infection rates, lockdown stringency, adherence to lockdown measures, air quality, or other social and economic markers, obtained from publicly available datasets. We will undertake an interrupted time series analysis covering births from January 2015 through July 2020. The iPOP Study will involve at least 121 researchers in 37 countries, including obstetricians, neonatologists, epidemiologists, public health researchers, environmental scientists, and policymakers. We will leverage the most disruptive and widespread \"natural experiment\" of our lifetime to make rapid discoveries about preterm birth. Whether the COVID-19 pandemic is worsening or unexpectedly improving perinatal outcomes, our research will provide critical new information to shape prenatal care strategies throughout (and well beyond) the pandemic.", "doi": "10.12688/wellcomeopenres.16507.1", "pmid": "34722933", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8524299"}], "notes": [], "created": "2021-11-02T15:31:32.649Z", "modified": "2021-11-02T15:31:33.258Z"}, {"entity": "publication", "iuid": "98576a905b2949ec84bfa0e9efb649c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/98576a905b2949ec84bfa0e9efb649c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/98576a905b2949ec84bfa0e9efb649c0"}}, "title": "Give more data, awareness and control to individual citizens, and they will help COVID-19 containment.", "authors": [{"family": "Nanni", "given": "Mirco", "initials": "M"}, {"family": "Andrienko", "given": "Gennady", "initials": "G"}, {"family": "Barab\u00e1si", "given": "Albert-L\u00e1szl\u00f3", "initials": "AL"}, {"family": "Boldrini", "given": "Chiara", "initials": "C"}, {"family": "Bonchi", "given": "Francesco", "initials": "F"}, {"family": "Cattuto", "given": "Ciro", "initials": "C"}, {"family": "Chiaromonte", "given": "Francesca", "initials": "F"}, {"family": "Comand\u00e9", "given": "Giovanni", "initials": "G"}, {"family": "Conti", "given": "Marco", "initials": "M"}, {"family": "Cot\u00e9", "given": "Mark", "initials": "M"}, {"family": "Dignum", "given": "Frank", "initials": "F"}, {"family": "Dignum", "given": "Virginia", "initials": "V"}, {"family": "Domingo-Ferrer", "given": "Josep", "initials": "J"}, {"family": "Ferragina", "given": "Paolo", "initials": "P"}, {"family": "Giannotti", "given": "Fosca", "initials": "F"}, {"family": "Guidotti", "given": "Riccardo", "initials": "R"}, {"family": "Helbing", "given": "Dirk", "initials": "D"}, {"family": "Kaski", "given": "Kimmo", "initials": "K"}, {"family": "Kertesz", "given": "Janos", "initials": "J"}, {"family": "Lehmann", "given": "Sune", "initials": "S"}, {"family": "Lepri", "given": "Bruno", "initials": "B"}, {"family": "Lukowicz", "given": "Paul", "initials": "P"}, {"family": "Matwin", "given": "Stan", "initials": "S"}, {"family": "Jim\u00e9nez", "given": "David Meg\u00edas", "initials": "DM"}, {"family": "Monreale", "given": "Anna", "initials": "A"}, {"family": "Morik", "given": "Katharina", "initials": "K"}, {"family": "Oliver", "given": "Nuria", "initials": "N"}, {"family": "Passarella", "given": "Andrea", "initials": "A"}, {"family": "Passerini", "given": "Andrea", "initials": "A"}, {"family": "Pedreschi", "given": "Dino", "initials": "D"}, {"family": "Pentland", "given": "Alex", "initials": "A"}, {"family": "Pianesi", "given": "Fabio", "initials": "F"}, {"family": "Pratesi", "given": "Francesca", "initials": "F"}, {"family": "Rinzivillo", "given": "Salvatore", "initials": "S"}, {"family": "Ruggieri", "given": "Salvatore", "initials": "S"}, {"family": "Siebes", "given": "Arno", "initials": "A"}, {"family": "Torra", "given": "Vicenc", "initials": "V"}, {"family": "Trasarti", "given": "Roberto", "initials": "R"}, {"family": "Hoven", "given": "Jeroen van den", "initials": "JVD"}, {"family": "Vespignani", "given": "Alessandro", "initials": "A"}], "type": "journal article", "published": "2021-02-02", "journal": {"title": "Ethics Inf Technol", "issn": "1388-1957", "volume": null, "issue": null, "pages": "1-6", "issn-l": null}, "abstract": "The rapid dynamics of COVID-19 calls for quick and effective tracking of virus transmission chains and early detection of outbreaks, especially in the \"phase 2\" of the pandemic, when lockdown and other restriction measures are progressively withdrawn, in order to avoid or minimize contagion resurgence. For this purpose, contact-tracing apps are being proposed for large scale adoption by many countries. A centralized approach, where data sensed by the app are all sent to a nation-wide server, raises concerns about citizens' privacy and needlessly strong digital surveillance, thus alerting us to the need to minimize personal data collection and avoiding location tracking. We advocate the conceptual advantage of a decentralized approach, where both contact and location data are collected exclusively in individual citizens' \"personal data stores\", to be shared separately and selectively (e.g., with a backend system, but possibly also with other citizens), voluntarily, only when the citizen has tested positive for COVID-19, and with a privacy preserving level of granularity. This approach better protects the personal sphere of citizens and affords multiple benefits: it allows for detailed information gathering for infected people in a privacy-preserving fashion; and, in turn this enables both contact tracing, and, the early detection of outbreak hotspots on more finely-granulated geographic scale. The decentralized approach is also scalable to large populations, in that only the data of positive patients need be handled at a central level. Our recommendation is two-fold. First to extend existing decentralized architectures with a light touch, in order to manage the collection of location data locally on the device, and allow the user to share spatio-temporal aggregates-if and when they want and for specific aims-with health authorities, for instance. Second, we favour a longer-term pursuit of realizing a Personal Data Store vision, giving users the opportunity to contribute to collective good in the measure they want, enhancing self-awareness, and cultivating collective efforts for rebuilding society.", "doi": "10.1007/s10676-020-09572-w", "pmid": "33551673", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "9572"}, {"db": "pmc", "key": "PMC7851322"}], "notes": [], "created": "2021-02-10T18:48:38.200Z", "modified": "2021-02-10T18:48:38.209Z"}, {"entity": "publication", "iuid": "d1867d7cef094b43aa4ba9d4261915fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1867d7cef094b43aa4ba9d4261915fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1867d7cef094b43aa4ba9d4261915fd"}}, "title": "The local governance of COVID-19: Disease prevention and social security in rural India.", "authors": [{"family": "Dutta", "given": "Anwesha", "initials": "A"}, {"family": "Fischer", "given": "Harry W", "initials": "HW"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "World Dev", "issn": "0305-750X", "issn-l": null, "volume": "138", "issue": null, "pages": "105234"}, "abstract": "Countries around the world have undertaken a wide range of strategies to halt the spread of COVID-19 and control the economic fallout left in its wake. Rural areas of developing countries pose particular difficulties for developing and implementing effective responses owing to underdeveloped health infrastructure, uneven state capacity for infection control, and endemic poverty. This paper makes the case for the critical role of local governance in coordinating pandemic response by examining how state authorities are attempting to bridge the gap between the need for rapid, vigorous response to the pandemic and local realities in three Indian states - Rajasthan, Odisha, and Kerala. Through a combination of interviews with mid and low-level bureaucrats and a review of policy documents, we show how the urgency of COVID-19 response has galvanized new kinds of cross-sectoral and multi-scalar interaction between administrative units involved in coordinating responses, as local governments have assumed central responsibility in the implementation of disease control and social security mechanisms. Evidence from Kerala in particular suggests that the state's long term investment in democratic local government and arrangements for incorporating women within grassroots state functions (through its Kudumbashree program) has built a high degree of public trust and cooperation with state actors, while local authorities embrace an ethic of care in the implementation of state responses. These observations, from the early months of the pandemic in South Asia, can serve as a foundation for future studies of how existing institutional arrangements and their histories pattern the long-term success of disease control and livelihood support as the pandemic proceeds. Governance, we argue, will be as important to understanding the trajectory of COVID-19 impacts and recovery as biology, demography, and economy.", "doi": "10.1016/j.worlddev.2020.105234", "pmid": "33106724", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0305-750X(20)30361-2"}, {"db": "pmc", "key": "PMC7578699"}], "notes": [], "created": "2020-11-27T11:47:52.870Z", "modified": "2021-01-22T16:08:54.437Z"}, {"entity": "publication", "iuid": "2f879921db144584abafdc455753d1da", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2f879921db144584abafdc455753d1da.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2f879921db144584abafdc455753d1da"}}, "title": "Richard Horton. The COVID-19 Catastrophe. What\u2019s Gone Wrong and How to Stop it Happening Again?", "authors": [{"family": "Allebeck", "given": "Peter", "initials": "P", "orcid": "0000-0002-2778-6467", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de9f0e1c3e4d402b93e61ad1c5a771fb.json"}}], "type": "journal-article", "published": "2021-02-01", "journal": {"title": "Eur J Public Health", "issn": "1101-1262", "volume": "31", "issue": "1", "pages": "234-234", "issn-l": null}, "abstract": null, "doi": "10.1093/eurpub/ckaa216", "pmid": "33231611", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "5998562"}], "notes": [], "created": "2020-11-26T12:36:05.407Z", "modified": "2023-06-19T07:33:25.394Z"}, {"entity": "publication", "iuid": "f01c7f0716244665a5ce072be3c80321", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f01c7f0716244665a5ce072be3c80321.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f01c7f0716244665a5ce072be3c80321"}}, "title": "Pregnant under the pressure of a pandemic: a large-scale longitudinal survey before and during the COVID-19 outbreak.", "authors": [{"family": "Naurin", "given": "Elin", "initials": "E"}, {"family": "Markstedt", "given": "Elias", "initials": "E"}, {"family": "Stolle", "given": "Dietlind", "initials": "D"}, {"family": "Enstr\u00f6m", "given": "Daniel", "initials": "D"}, {"family": "Wallin", "given": "Anton", "initials": "A"}, {"family": "Andreasson", "given": "Ingrid", "initials": "I"}, {"family": "Attebo", "given": "Birgitta", "initials": "B"}, {"family": "Eriksson", "given": "Ottilia", "initials": "O"}, {"family": "Martinsson", "given": "Klara", "initials": "K"}, {"family": "Elden", "given": "Helen", "initials": "H"}, {"family": "Linden", "given": "Karolina", "initials": "K"}, {"family": "Sengpiel", "given": "Verena", "initials": "V"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": "31", "issue": "1", "pages": "7-13"}, "abstract": "One of the groups that is most vulnerable to the COVID-19 pandemic is pregnant women. They cannot choose to refrain from care; they and their children are at risk of severe complications related to the virus; and they lose comfort and support as clinics prohibit their partners and as societal restrictions demand isolation from friends and relatives. It is urgent to study how this group is faring during the pandemic and we focus here on their health-related worries.\r\n\r\nA longitudinal survey at a Swedish hospital starting 6 months before (16 September 2019) and continuing during the COVID-19 outbreak (until 25 August 2020). A total of 6941 pregnant women and partners of diverse social backgrounds were recruited. Ninety-six percent of birth-giving women in the city take early ultrasounds where recruitment took place. Sixty-two percent of the women with an appointment and fifty-one percent of all partners gave consent to participate.\r\n\r\nPregnant women experienced dramatically increased worries for their own health, as well as for their partner's and their child's health in the beginning of the pandemic. The worries remained at higher than usual levels throughout the pandemic. Similar, but less dramatic changes were seen among partners.\r\n\r\nThere is a need for heightened awareness of pregnant women's and partners' health-related worries as a consequence of the COVID-19 pandemic. Related feelings, such as anxiety, have been linked to adverse pregnancy outcome and might have long-term effects. The healthcare system needs to prepare for follow-up visits with these families.", "doi": "10.1093/eurpub/ckaa223", "pmid": "33231625", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "5999799"}, {"db": "pmc", "key": "PMC7717243"}], "notes": [], "created": "2021-02-10T18:53:52.023Z", "modified": "2021-06-18T11:48:16.756Z"}, {"entity": "publication", "iuid": "d3af55f4e3e041e991b21009616ebc1b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3af55f4e3e041e991b21009616ebc1b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3af55f4e3e041e991b21009616ebc1b"}}, "title": "Inflammatory bowel disease and risk of severe COVID-19: A nationwide population-based cohort study in Sweden.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}, {"family": "Axelrad", "given": "Jordan", "initials": "J"}, {"family": "Halfvarson", "given": "Jonas", "initials": "J"}, {"family": "Khalili", "given": "Hamed", "initials": "H"}, {"family": "Larsson", "given": "Emma", "initials": "E"}, {"family": "Lochhead", "given": "Paul", "initials": "P"}, {"family": "Roelstraete", "given": "Bjorn", "initials": "B"}, {"family": "Simon", "given": "Tracey G", "initials": "TG"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Ol\u00e9n", "given": "Ola", "initials": "O"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "United European Gastroenterol J", "issn": "2050-6414", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "There are concerns that individuals with chronic immune-mediated diseases are at increased risk of COVID-19 and related severe adverse outcome, including intensive care admission or death. We aimed to explore the absolute and relative risk of severe COVID-19 in inflammatory bowel disease (IBD).\r\n\r\nThis population-based cohort study used nationwide registers in Sweden, with 67,292 individuals with a diagnosis of IBD 1969-2017 (Crohn's disease, n = 21,599; ulcerative colitis: n = 43,622; IBD-unclassified: n = 2071) and alive on 1 February 2020. Patients with IBD were matched to up to five controls from the general population (n = 297,910). Cox regression estimated hazard ratios (HRs) for (i) hospital admission with laboratory-confirmed COVID-19 as the primary diagnosis, and (ii) severe COVID-19 (composite outcome consisting of (a) COVID-19 intensive care admission, or (b) death from COVID-19 or (c) death within 30 days of COVID-19 hospital admission), were calculated. Analyses were conditioned on age, sex, calendar period, and county and adjusted for other comorbidities.\r\n\r\nBetween 1 February and 31 July 2020, 179 (0.27%) IBD patients and 500 (0.17%) general population controls were admitted to hospital with COVID-19 (adjusted HR [aHR] = 1.43; 95% CI = 1.19-1.72). The corresponding numbers for severe COVID-19 was 65 (0.10%) and 183 (0.06%; aHR = 1.11; 95% CI = 0.81-1.52). Adjusted HRs were similar in Crohn's disease and ulcerative colitis. In a propensity score-matched model taking comorbidity into account until 2016, the increased risk for COVID-19 hospital admission remained (aHR = 1.32; 1.12-1.56), but there was no increased risk of severe COVID-19 (aHR = 1.12; 0.85-1.47).\r\n\r\nWhile individuals with IBD were more likely to be admitted to hospital for COVID-19 than the general population, the risk of severe COVID-19 was not higher.", "doi": "10.1002/ueg2.12049", "pmid": "33704918", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-12T07:00:21.836Z", "modified": "2021-06-18T11:48:54.131Z"}, {"entity": "publication", "iuid": "87a74bf619444236aae8b3fba8ddf289", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87a74bf619444236aae8b3fba8ddf289.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87a74bf619444236aae8b3fba8ddf289"}}, "title": "Impact of COVID-19 lockdown on NO 2, O3, PM2.5 and PM10 concentrations and assessing air quality changes in Baghdad, Iraq.", "authors": [{"family": "Hashim", "given": "Bassim Mohammed", "initials": "BM"}, {"family": "Al-Naseri", "given": "Saadi K", "initials": "SK"}, {"family": "Al-Maliki", "given": "Ali", "initials": "A"}, {"family": "Al-Ansari", "given": "Nadhir", "initials": "N"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "volume": "754", "issue": null, "pages": "141978", "issn-l": "0048-9697"}, "abstract": "Covid-19 was first reported in Iraq on February 24, 2020. Since then, to prevent its propagation, the Iraqi government declared a state of health emergency. A set of rapid and strict countermeasures have taken, including locking down cities and limiting population's mobility. In this study, concentrations of four criteria pollutants, NO 2, O3, PM2.5 and PM10 before the lockdown from January 16 to February 29, 2020, and during four periods of partial and total lockdown from March 1 to July 24, 2020, in Baghdad were analysed. Overall, 6, 8 and 15% decreases in NO2, PM2.5, and PM10 concentrations, respectively in Baghdad during the 1st partial and total lockdown from March 1 to April 21, compared to the period before the lockdown. While, there were 13% increase in O3 for same period. During the 2nd partial lockdown from June 14 to July 24, NO2 and PM2.5 decreases 20 and 2.5%, respectively. While, there were 525 and 56% increase in O3 and PM10, respectively for same period. The air quality index (AQI) improved by 13% in Baghdad during the 1st partial lockdown from March 1 to April 21, compared to its pre-lockdown. The results of NO2 tropospheric column extracted from the Sentinel-5P satellite shown the NO2 emissions reduced up to 35 to 40% across Iraq, due to lockdown measures, between January and July, 2020, especially across the major cities such as Baghdad, Basra and Erbil. The lockdown due to COVID-19 has drastic effects on social and economic aspects. However, the lockdown also has some positive effect on natural environment and air quality improvement.", "doi": "10.1016/j.scitotenv.2020.141978", "pmid": "32919315", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(20)35507-8"}, {"db": "pmc", "key": "PMC7462443"}], "notes": [], "created": "2020-12-03T15:39:23.953Z", "modified": "2021-02-26T08:46:13.355Z"}, {"entity": "publication", "iuid": "636180d45c4142939f2ff87323885946", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/636180d45c4142939f2ff87323885946.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/636180d45c4142939f2ff87323885946"}}, "title": "Funcoup 5: Functional association networks in all domains of life, supporting directed links and tissue-specificity.", "authors": [{"family": "Persson", "given": "Emma", "initials": "E"}, {"family": "Castresana-Aguirre", "given": "Miguel", "initials": "M"}, {"family": "Buzzao", "given": "Davide", "initials": "D"}, {"family": "Guala", "given": "Dimitri", "initials": "D"}, {"family": "Sonnhammer", "given": "Erik L L", "initials": "ELL"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "J Mol Biol", "issn": "1089-8638", "issn-l": null, "volume": null, "issue": null, "pages": "166835"}, "abstract": "FunCoup (https://funcoup.sbc.su.se) is one of the most comprehensive functional association networks of genes/proteins available. Functional associations are inferred by integrating different types of evidence using a redundancy-weighted na\u00efve Bayesian approach, combined with orthology transfer. FunCoup's high coverage comes from using eleven different types of evidence, and extensive transfer of information between species. Since the latest update of the database, the availability of source data has improved drastically, and user expectations on a tool for functional associations have grown. To meet these requirements, we have made a new release of FunCoup with updated source data and improved functionality. FunCoup 5 now includes 22 species from all domains of life, and the source data for evidences, gold standards, and genomes have been updated to the latest available versions. In this new release, directed regulatory links inferred from transcription factor binding can be visualized in the network viewer for the human interactome. Another new feature is the possibility to filter by genes expressed in a certain tissue in the network viewer. FunCoup 5 further includes the SARS-CoV-2 proteome, allowing users to visualize and analyze interactions between SARS-CoV-2 and human proteins in order to better understand COVID-19. This new release of FunCoup constitutes a major advance for the users, with updated sources, new species and improved functionality for analysis of the networks.", "doi": "10.1016/j.jmb.2021.166835", "pmid": "33539890", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0022-2836(21)00029-2"}], "notes": [], "created": "2021-02-05T11:28:55.073Z", "modified": "2021-08-25T14:25:20.925Z"}, {"entity": "publication", "iuid": "9b6e4f24074b4cdb818625428a92e182", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b6e4f24074b4cdb818625428a92e182.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b6e4f24074b4cdb818625428a92e182"}}, "title": "Excess mortality from COVID-19: weekly excess death rates by age and sex for Sweden and its most affected region.", "authors": [{"family": "Modig", "given": "Karin", "initials": "K"}, {"family": "Ahlbom", "given": "Anders", "initials": "A"}, {"family": "Ebeling", "given": "Marcus", "initials": "M"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": "31", "issue": "1", "pages": "17-22"}, "abstract": "Sweden has one of the highest numbers of COVID-19 deaths per inhabitant globally. However, absolute death counts can be misleading. Estimating age- and sex-specific mortality rates is necessary in order to account for the underlying population structure. Furthermore, given the difficulty of assigning causes of death, excess all-cause mortality should be estimated to assess the overall burden of the pandemic.\n\nBy estimating weekly age- and sex-specific death rates during 2020 and during the preceding 5 years, our aim is to get more accurate estimates of the excess mortality attributed to COVID-19 in Sweden, and in the most affected region Stockholm.\n\nEight weeks after Sweden's first confirmed case, the death rates at all ages above 60 were higher than for previous years. Persons above age 80 were disproportionally more affected, and men suffered greater excess mortality than women in ages up to 75 years. At older ages, the excess mortality was similar for men and women, with up to 1.5 times higher death rates for Sweden and up to 3 times higher for Stockholm. Life expectancy at age 50 declined by <1 year for Sweden and 1.5 years for Stockholm compared to 2019.\n\nThe excess mortality has been high in older ages during the pandemic, but it remains to be answered if this is because of age itself being a prognostic factor or a proxy for comorbidity. Only monitoring deaths at a national level may hide the effect of the pandemic on the regional level.", "doi": "10.1093/eurpub/ckaa218", "pmid": "33169145", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "5968985"}, {"db": "pmc", "key": "PMC7717265"}], "notes": [], "created": "2021-06-14T06:37:23.104Z", "modified": "2021-09-23T05:11:34.318Z"}, {"entity": "publication", "iuid": "302719fae97442a58c88e35043be6d72", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/302719fae97442a58c88e35043be6d72.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/302719fae97442a58c88e35043be6d72"}}, "title": "Early humoral defense: Contributing to confining Covid-19 to conducting airways?", "authors": [{"family": "Persson", "given": "Carl", "initials": "C"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "Scand J Immunol", "issn": "1365-3083", "volume": null, "issue": null, "pages": "e13024", "issn-l": null}, "abstract": "Early airway responses to Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection are of interest since they could decide whether Coronavirus disease-19 (Covid-19) will proceed to life-threatening pulmonary disease stages. Here I discuss endothelial-epithelial co-operative in vivo-responses producing first-line, humoral innate defense opportunities in human airways. The pseudostratified epithelium of human nasal and tracheobronchial airways are prime sites of exposure and infection by SARS-CoV-2. Just beneath the epithelium runs a profuse systemic microcirculation. Its postcapillary venules respond conspicuously to mucosal challenges with autacoids, allergens, and microbes, and to mere loss of epithelium. By active venular endothelial gap formation, followed by transient yielding of epithelial junctions, non-sieved plasma macromolecules move from the microcirculation to the mucosal surface. Hence, plasma-derived protein cascade systems and antimicrobial peptides would have opportunity to operate jointly on an unperturbed mucosal lining. Similarly, a plasma-derived, dynamic gel protects sites of epithelial sloughing-regeneration. Precision for this indiscriminate humoral molecular response lies in restricted location and well-regulated duration of plasma exudation. Importantly, the endothelial responsiveness of the airway microcirculation differs distinctly from the relatively non-responsive, low-pressure pulmonary microcirculation that non-specifically, almost irreversibly, leaks plasma in life-threatening Covid-19. Observations in humans of infections with rhinovirus, corona virus 229E, and influenza A and B, support a general but individually variable early occurrence of plasma exudation in human infected nasal and tracheobronchial airways. Investigations are warranted to elucidate roles of host- and drug-induced airways plasma exudation in restriction of viral infection and, specifically, whether it contributes to variable disease-responses following exposure to SARS-CoV-2.", "doi": "10.1111/sji.13024", "pmid": "33523532", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-04T18:24:22.565Z", "modified": "2021-02-04T18:24:22.587Z"}, {"entity": "publication", "iuid": "1491b4b81ef944f4b9b00b9235cbd797", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1491b4b81ef944f4b9b00b9235cbd797.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1491b4b81ef944f4b9b00b9235cbd797"}}, "title": "Decay of SARS-CoV-2 RNA along the wastewater treatment outfitted with Upflow Anaerobic Sludge Blanket (UASB) system evaluated through two sample concentration techniques.", "authors": [{"family": "Kumar", "given": "Manish", "initials": "M"}, {"family": "Kuroda", "given": "Keisuke", "initials": "K"}, {"family": "Patel", "given": "Arbind Kumar", "initials": "AK"}, {"family": "Patel", "given": "Nidhi", "initials": "N"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Joshi", "given": "Madhvi", "initials": "M"}, {"family": "Joshi", "given": "Chaitanya G", "initials": "CG"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "issn-l": "0048-9697", "volume": "754", "issue": null, "pages": "142329"}, "abstract": "For the first time, we present, i) an account of decay in the genetic material loading of SARS-CoV-2 during Upflow Anaerobic Sludge Blanket (UASB) treatment of wastewater, and ii) comparative evaluation of polyethylene glycol (PEG), and ultrafiltration as virus concentration methods from wastewater for the quantification of SARS-CoV-2 genes. The objectives were achieved through tracking of SARS-CoV-2 genetic loadings i.e. ORF1ab, N and S protein genes on 8th and 27th May 2020 along the wastewater treatment plant (106000 m 3 million liters per day) equipped with UASB system in Ahmedabad, India. PEG method performed better in removing materials inhibiting RT-qPCR for SARS-CoV-2 gene detection from the samples, as evident from constant and lower CT values of control (MS2). Using the PEG method, we found a reduction >1.3 log10 reduction in SARS-CoV-2 RNA abundance during UASB treatment, and the RNA was not detected at all in the final effluent. The study implies that i) conventional wastewater treatment systems is effective in SARS-CoV-2 RNA removal, and ii) UASB system significantly reduces SARS-CoV-2 genetic loadings. Finally, PEG method is recommended for better sensitivity and inhibition removal during SARS-CoV-2 RNA quantification in wastewater.", "doi": "10.1016/j.scitotenv.2020.142329", "pmid": "33254951", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(20)35858-7"}], "notes": [], "created": "2020-12-03T08:20:09.557Z", "modified": "2021-02-26T08:46:12.935Z"}, {"entity": "publication", "iuid": "098cd3e85b5d489bbab5e2dbb82d2f33", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/098cd3e85b5d489bbab5e2dbb82d2f33.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/098cd3e85b5d489bbab5e2dbb82d2f33"}}, "title": "Assessment of Suicide in Japan During the COVID-19 Pandemic vs Previous Years.", "authors": [{"family": "Sakamoto", "given": "Haruka", "initials": "H"}, {"family": "Ishikane", "given": "Masahiro", "initials": "M"}, {"family": "Ghaznavi", "given": "Cyrus", "initials": "C"}, {"family": "Ueda", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "issn-l": null, "volume": "4", "issue": "2", "pages": "e2037378"}, "abstract": "There are concerns that suicide rates may have increased during the coronavirus disease 2019 (COVID-19) pandemic.\r\n\r\nTo assess whether suicide rates in Japan increased in April through November 2020 compared with previous years.\r\n\r\nThis cross-sectional study used national data obtained from the Ministry of Health, Labor and Welfare from 2016 to 2020 on the monthly number of individuals who died of suicide in Japan from January to November of 2016 to 2020.\r\n\r\n2020 vs previous years.\r\n\r\nThe main outcome was monthly suicide rates, calculated as the number of individuals who died of suicide divided by the total population. A difference-in-difference regression model was used to estimate the change in monthly suicide rates in April to November 2020 vs these months in 2016 to 2019.\r\n\r\nAnalyses included 90 048 individuals (61 366 [68.1%] men) who died of suicide from 2016 to 2020. The difference-in-difference analysis of men showed that there was no increase in suicide rates from April through September 2020 compared with these months in 2016 to 2019, but that suicide rates were increased in October (difference-in-difference, 0.40 [95% CI, 0.14 to 0.67] suicide deaths per 100 000 population) and November (difference-in-difference, 0.34 [95% CI, 0.07 to 0.60] suicide deaths per 100 000 population). Among women, suicide rates in 2020 compared with 2016 to 2019 increased in July (difference-in-difference, 0.24 [95% CI, 0.09 to 0.38] suicide deaths per 100 000 population), August (difference-in-difference, 0.30 [95% CI, 0.16 to 0.45] suicide deaths per 100 000 population), September (difference-in-difference, 0.29 [95% CI, 0.15 to 0.44] suicide deaths per 100 000 population), October (difference-in-difference, 0.62 [95% CI, 0.48 to 0.77] suicide deaths per 100 000 population), and November (difference-in-difference, 0.29 [95% CI, 0.15 to 0.44] suicide deaths per 100 000 population). In secondary analyses in which the suicide rates of 2020 were compared with the expected rates based on trends from 2011 to 2019, the increases in suicide rates were most pronounced among men aged younger than 30 years (eg, November: observed vs expected rate ratio [RR], 1.48 [95% CI, 1.26-1.71]) and women aged younger than 30 years (eg, October: observed vs expected RR, 2.14 [95% CI, 1.76 to 2.52]) and 30 to 49 years (eg, October: observed vs expected RR, 2.30 [95% CI, 2.01 to 2.58]).\r\n\r\nThese findings suggest that compared with previous years, suicide rates in Japan in 2020 increased in October and November for men and in July through November for women.", "doi": "10.1001/jamanetworkopen.2020.37378", "pmid": "33528554", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "2775740"}], "notes": [], "created": "2021-02-04T18:23:24.857Z", "modified": "2021-06-18T11:16:04.908Z"}, {"entity": "publication", "iuid": "ddbf17922ce142488599dc803aded789", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ddbf17922ce142488599dc803aded789.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ddbf17922ce142488599dc803aded789"}}, "title": "Risk of Severe Covid-19 in Patients with Celiac Disease: A Population-Based Cohort Study", "authors": [{"family": "Lebwohl", "given": "Benjamin", "initials": "B"}, {"family": "Larsson", "given": "Emma", "initials": "E"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Roelstraete", "given": "Bjorn", "initials": "B"}, {"family": "Murray", "given": "Joseph A", "initials": "JA"}, {"family": "Green", "given": "Peter HR", "initials": "PH"}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "journal-article", "published": "2021-02-00", "journal": {"title": "CLEP", "issn": "1179-1349", "volume": "Volume 13", "issue": null, "pages": "121-130", "issn-l": null}, "abstract": null, "doi": "10.2147/clep.s294391", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-25T12:30:09.922Z", "modified": "2021-02-26T08:47:00.236Z"}, {"entity": "publication", "iuid": "1d63ea6dcd2544f9b0421a69d04ab013", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d63ea6dcd2544f9b0421a69d04ab013.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d63ea6dcd2544f9b0421a69d04ab013"}}, "title": "Reflections on Virtual Care for Chronic Conditions During the COVID-19 Pandemic.", "authors": [{"family": "Wittmeier", "given": "Kristy D M", "initials": "KDM"}, {"family": "Protudjer", "given": "Jennifer L P", "initials": "JLP"}, {"family": "Wicklow", "given": "Brandy A", "initials": "BA"}], "type": "editorial", "published": "2021-02-00", "journal": {"title": "Can J Diabetes", "issn": "2352-3840", "volume": "45", "issue": "1", "pages": "1-2", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jcjd.2020.11.013", "pmid": "33500126", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1499-2671(20)30468-8"}], "notes": [], "created": "2021-01-29T15:20:38.702Z", "modified": "2021-01-29T15:20:38.727Z"}, {"entity": "publication", "iuid": "6cad7393922b4bdab063ef4a5b4e2db5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6cad7393922b4bdab063ef4a5b4e2db5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6cad7393922b4bdab063ef4a5b4e2db5"}}, "title": "Presymptomatic viral shedding and infective ability of SARS-CoV-2; a case report.", "authors": [{"family": "Nissen", "given": "Karolina", "initials": "K"}, {"family": "Hagbom", "given": "Marie", "initials": "M"}, {"family": "Krambrich", "given": "Janina", "initials": "J"}, {"family": "Akaberi", "given": "Dario", "initials": "D"}, {"family": "Sharma", "given": "Sumit", "initials": "S"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Svensson", "given": "Lennart", "initials": "L"}, {"family": "Bondeson", "given": "K\u00e5re", "initials": "K"}, {"family": "Salaneck", "given": "Erik", "initials": "E"}], "type": "case reports", "published": "2021-02-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "issn-l": null, "volume": "7", "issue": "2", "pages": "e06328"}, "abstract": "Possible pre- or asymptomatic transmission has been reported, both from SARS-CoV and from MERS-CoV outbreaks, although this appears to be uncommon. In contrast, during the COVID-19 pandemic, an increasing number of studies and case reports indicate that pre- or asymptomatic transmission of SARS-CoV-2 is not only possible but also occurs frequently. We report repeated rRT-PCR detection of SARS-CoV-2 in a health care worker and demonstrate infective ability up to three days prior to mild COVID-19 symptoms. rRT-PCR indicated high viral levels approximately three days after exposure. Viral samples collected one and three days prior to symptoms exhibited infectivity on Vero E6 cells, confirmed by detection of double-stranded RNA by immunofluorescence, assessment of cytopathic effect (CPE) and rRT-PCR. SARS-CoV-2 specific IgM and IgG antibodies were detected by day 9 and 15, respectively, after symptom onset. We propose that this provides evidence for potential early presymptomatic transmission of SARS-CoV-2 and that infectivity may be manifest shortly after exposure.", "doi": "10.1016/j.heliyon.2021.e06328", "pmid": "33644482", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)00433-3"}, {"db": "pmc", "key": "PMC7894094"}], "notes": [], "created": "2021-03-02T06:53:25.256Z", "modified": "2021-06-18T11:15:39.188Z"}, {"entity": "publication", "iuid": "69841acb8a304e629226b7c50efe0667", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69841acb8a304e629226b7c50efe0667.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69841acb8a304e629226b7c50efe0667"}}, "title": "Point of view on the vaccination against COVID-19 in patients with autoimmune inflammatory rheumatic diseases.", "authors": [{"family": "Furer", "given": "Victoria", "initials": "V", "orcid": "0000-0001-5193-4207", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/17050dc675254cd59533c6568f60db38.json"}}, {"family": "Rondaan", "given": "Christien", "initials": "C", "orcid": "0000-0002-4558-1270", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a1288a4e4e54e2380de0649962e0322.json"}}, {"family": "Agmon-Levin", "given": "Nancy", "initials": "N"}, {"family": "van Assen", "given": "Sander", "initials": "S"}, {"family": "Bijl", "given": "Marc", "initials": "M"}, {"family": "Kapetanovic", "given": "Meliha Crnkic", "initials": "MC"}, {"family": "de Thurah", "given": "Annette", "initials": "A", "orcid": "0000-0003-0103-4328", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2450d24c34eb4edeb270e0b576635a12.json"}}, {"family": "Mueller-Ladner", "given": "Ulf", "initials": "U"}, {"family": "Paran", "given": "Daphna", "initials": "D"}, {"family": "Schreiber", "given": "Karen", "initials": "K"}, {"family": "Warnatz", "given": "Klaus", "initials": "K"}, {"family": "Wulffraat", "given": "Nico M", "initials": "NM"}, {"family": "Elkayam", "given": "Ori", "initials": "O"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "RMD Open", "issn": "2056-5933", "volume": "7", "issue": "1", "pages": "e001594", "issn-l": null}, "abstract": "In view of the COVID-19 pandemic, there is an unmet clinical need for the guidelines on vaccination of patients with autoimmune inflammatory rheumatic diseases (AIIRD). This position paper summarises the current data on COVID-19 infection in patients with AIIRD and development of vaccines against COVID-19, discusses the aspects of efficacy and safety of vaccination, and proposes preliminary considerations on vaccination against COVID-19 in patients with AIIRD, mainly based on the expert opinion and knowledge on the use of other vaccines in this population of patients.", "doi": "10.1136/rmdopen-2021-001594", "pmid": "33627440", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "rmdopen-2021-001594"}, {"db": "pmc", "key": "PMC7907831"}], "notes": [], "created": "2021-02-25T14:57:13.800Z", "modified": "2021-07-14T07:52:36.535Z"}, {"entity": "publication", "iuid": "487865ba9e4b446b9097b0d17ff1ecb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/487865ba9e4b446b9097b0d17ff1ecb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/487865ba9e4b446b9097b0d17ff1ecb1"}}, "title": "Persistence of IgG response to SARS-CoV-2.", "authors": [{"family": "Duysburgh", "given": "Els", "initials": "E"}, {"family": "Mortgat", "given": "Laure", "initials": "L"}, {"family": "Barbezange", "given": "Cyril", "initials": "C"}, {"family": "Dierick", "given": "Katelijne", "initials": "K"}, {"family": "Fischer", "given": "Natalie", "initials": "N"}, {"family": "Heyndrickx", "given": "Leo", "initials": "L"}, {"family": "Hutse", "given": "Veronik", "initials": "V"}, {"family": "Thomas", "given": "Isabelle", "initials": "I"}, {"family": "Van Gucht", "given": "Steven", "initials": "S"}, {"family": "Vuylsteke", "given": "Bea", "initials": "B"}, {"family": "Ari\u00ebn", "given": "Kevin K", "initials": "KK"}, {"family": "Desombere", "given": "Isabelle", "initials": "I"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "issn-l": null, "volume": "21", "issue": "2", "pages": "163-164"}, "abstract": null, "doi": "10.1016/S1473-3099(20)30943-9", "pmid": "33341124", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(20)30943-9"}, {"db": "pmc", "key": "PMC7833610"}], "notes": [], "created": "2021-01-10T18:08:16.831Z", "modified": "2021-07-14T07:49:21.276Z"}, {"entity": "publication", "iuid": "a4dcb004fb8140fbb690fb73057e327e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a4dcb004fb8140fbb690fb73057e327e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a4dcb004fb8140fbb690fb73057e327e"}}, "title": "Pediatric COVID-19 Cases Prelockdown and Postlockdown in Italy.", "authors": [{"family": "Bellino", "given": "Stefania", "initials": "S"}, {"family": "Rota", "given": "Maria Cristina", "initials": "MC"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Mateo Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Punzo", "given": "Ornella", "initials": "O"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Villani", "given": "Alberto", "initials": "A"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "COVID-19 Working Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Pediatrics", "issn": "1098-4275", "volume": "147", "issue": "2", "issn-l": null}, "abstract": null, "doi": "10.1542/peds.2020-035238", "pmid": "33154154", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "peds.2020-035238"}], "notes": [], "created": "2021-02-10T18:54:40.193Z", "modified": "2021-02-26T08:47:00.137Z"}, {"entity": "publication", "iuid": "2f959e159f0a4064b0bf49d2d8f84427", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2f959e159f0a4064b0bf49d2d8f84427.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2f959e159f0a4064b0bf49d2d8f84427"}}, "title": "Online health survey research during COVID-19", "authors": [{"family": "Hlatshwako", "given": "Takhona G", "initials": "TG"}, {"family": "Shah", "given": "Sonam J", "initials": "SJ"}, {"family": "Kosana", "given": "Priya", "initials": "P"}, {"family": "Adebayo", "given": "Emmanuel", "initials": "E"}, {"family": "Hendriks", "given": "Jacqueline", "initials": "J"}, {"family": "Larsson", "given": "Elin C", "initials": "EC"}, {"family": "Hensel", "given": "Devon J", "initials": "DJ"}, {"family": "Erausquin", "given": "Jennifer Toller", "initials": "JT"}, {"family": "Marks", "given": "Michael", "initials": "M"}, {"family": "Michielsen", "given": "Kristien", "initials": "K"}, {"family": "Saltis", "given": "Hanna", "initials": "H"}, {"family": "Francis", "given": "Joel M", "initials": "JM"}, {"family": "Wouters", "given": "Edwin", "initials": "E"}, {"family": "Tucker", "given": "Joseph D", "initials": "JD"}], "type": "journal-article", "published": "2021-02-00", "journal": {"title": "The Lancet Digital Health", "issn": "2589-7500", "issn-l": null, "volume": "3", "issue": "2", "pages": "e76-e77"}, "abstract": null, "doi": "10.1016/s2589-7500(21)00002-9", "pmid": "33509387", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-29T15:11:39.497Z", "modified": "2021-02-15T19:17:59.351Z"}, {"entity": "publication", "iuid": "8662c05a2e6c4dab89413bfd6652c32e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8662c05a2e6c4dab89413bfd6652c32e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8662c05a2e6c4dab89413bfd6652c32e"}}, "title": "Lingonberry polyphenols: Potential SARS-CoV-2 inhibitors as nutraceutical tools?", "authors": [{"family": "P\u00e4rn\u00e4nen", "given": "Pirjo", "initials": "P"}, {"family": "L\u00e4hteenm\u00e4ki", "given": "Hanna", "initials": "H"}, {"family": "R\u00e4is\u00e4nen", "given": "Ismo", "initials": "I"}, {"family": "Tervahartiala", "given": "Taina", "initials": "T"}, {"family": "Sorsa", "given": "Timo", "initials": "T"}], "type": "letter", "published": "2021-02-00", "journal": {"title": "Physiol Rep", "issn": "2051-817X", "volume": "9", "issue": "3", "pages": "e14741", "issn-l": null}, "abstract": "Proposed pathway of the effect of lingonberry polyphenols on oral microbial (viral) load reduction and consequent beneficial local and systemic (respiratory tract) anti-inflammatory and antimicrobial/antiviral effects.", "doi": "10.14814/phy2.14741", "pmid": "33527774", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-04T18:23:55.661Z", "modified": "2021-02-04T18:23:55.683Z"}, {"entity": "publication", "iuid": "fd6a374bb2da4ca3b85dacb8f68a68a5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fd6a374bb2da4ca3b85dacb8f68a68a5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fd6a374bb2da4ca3b85dacb8f68a68a5"}}, "title": "Leveraging epidemiological principles to evaluate Sweden's COVID-19 response.", "authors": [{"family": "Baral", "given": "Stefan", "initials": "S"}, {"family": "Chandler", "given": "Rebecca", "initials": "R"}, {"family": "Prieto", "given": "Ruth Gil", "initials": "RG"}, {"family": "Gupta", "given": "Sunetra", "initials": "S"}, {"family": "Mishra", "given": "Sharmistha", "initials": "S"}, {"family": "Kulldorff", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Ann Epidemiol", "issn": "1873-2585", "volume": "54", "issue": null, "pages": "21-26", "issn-l": null}, "abstract": "In the response to COVID-19, countries have implemented response strategies along a continuum of population- and venue-level specificity ranging from suppression to mitigation strategies. Suppression strategies generally include population-wide shelter-in-place mandates or lockdowns, closure of nonessential physical venues, travel bans, testing and contact tracing, and quarantines. Sweden followed a mitigation strategy focused on risk-tailored approaches to mitigate specific acquisition risks among the elderly, minimizing the disruption to education and the delivery of other health care services, and recommendations for social distancing to minimize the disease burden. To date, Sweden has reported higher case counts and attributable mortality than other Scandinavian countries and lower than other Northern European countries. However, there are several limitations with comparison given heterogeneity in testing strategies, suspected and confirmed case definitions, and assessment of attributable mortality. The decisions in Sweden also reflect social priorities such as equity being a foundational principle of Swedish social systems. Consistently, in-person education for those aged less than 16 years continued throughout. Notably, the mitigation strategy did not eliminate the inequitable impacts of COVID-19 cases and mortality in Sweden with higher-exposure and generally lower-income occupations being associated with higher risks intersecting with these communities often residing in more dense multigenerational households. From January 1 to November 15, there has been a 1.8% increase in all-cause mortality in 2020 compared with the average of 2015-2019, representing an excess of 14.3 deaths per 100,000 population. However, the final assessment of excess deaths in Sweden in 2020 including stratification by age and integration of secular trends can only be calculated in the coming years. In response to increasing cases in the fall of 2020, Sweden has continued to leverage business-oriented regulations and public-oriented guidelines for social distancing rather than police-enforced mandates. Ultimately, pandemics present no winners. Countries have implemented a range of different COVID-19 prevention and mitigation strategies responsive to their own priorities and legal systems including equity and the balancing of competing health priorities. Given these varied approaches, countries that pursued elimination, suppression, or mitigation strategies can collaboratively learn from both successes and challenges of the different strategies to inform COVID-19 and future pandemic responses.", "doi": "10.1016/j.annepidem.2020.11.005", "pmid": "33242596", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7682427"}, {"db": "pii", "key": "S1047-2797(20)30413-0"}], "notes": [], "created": "2020-11-30T07:46:01.828Z", "modified": "2023-01-13T13:27:50.907Z"}, {"entity": "publication", "iuid": "7d8d997669864c078e5036277c77f2c4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d8d997669864c078e5036277c77f2c4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d8d997669864c078e5036277c77f2c4"}}, "title": "Just allocation of COVID-19 vaccines.", "authors": [{"family": "Herlitz", "given": "Anders", "initials": "A"}, {"family": "Lederman", "given": "Zohar", "initials": "Z"}, {"family": "Miller", "given": "Jennifer", "initials": "J"}, {"family": "Fleurbaey", "given": "Marc", "initials": "M"}, {"family": "Venkatapuram", "given": "Sridhar", "initials": "S"}, {"family": "Atuire", "given": "Caesar", "initials": "C"}, {"family": "Eckenwiler", "given": "Lisa", "initials": "L"}, {"family": "Hassoun", "given": "Nicole", "initials": "N"}], "type": "editorial", "published": "2021-02-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "2", "issn-l": "2059-7908"}, "abstract": null, "doi": "10.1136/bmjgh-2020-004812", "pmid": "33589419", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-004812"}], "notes": [], "created": "2021-02-17T14:52:59.770Z", "modified": "2021-02-17T14:53:17.075Z"}, {"entity": "publication", "iuid": "9b83ecfd2cf74c0fb5506f4188b70b13", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b83ecfd2cf74c0fb5506f4188b70b13.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b83ecfd2cf74c0fb5506f4188b70b13"}}, "title": "Indirect acute effects of the COVID-19 pandemic on physical and mental health in the UK: a population-based study", "authors": [{"family": "Mansfield", "given": "Kathryn E", "initials": "KE"}, {"family": "Mathur", "given": "Rohini", "initials": "R"}, {"family": "Tazare", "given": "John", "initials": "J"}, {"family": "Henderson", "given": "Alasdair D", "initials": "AD"}, {"family": "Mulick", "given": "Amy R", "initials": "AR"}, {"family": "Carreira", "given": "Helena", "initials": "H"}, {"family": "Matthews", "given": "Anthony A", "initials": "AA"}, {"family": "Bidulka", "given": "Patrick", "initials": "P"}, {"family": "Gayle", "given": "Alicia", "initials": "A"}, {"family": "Forbes", "given": "Harriet", "initials": "H"}, {"family": "Cook", "given": "Sarah", "initials": "S"}, {"family": "Wong", "given": "Angel Y S", "initials": "AYS"}, {"family": "Strongman", "given": "Helen", "initials": "H"}, {"family": "Wing", "given": "Kevin", "initials": "K"}, {"family": "Warren-Gash", "given": "Charlotte", "initials": "C"}, {"family": "Cadogan", "given": "Sharon L", "initials": "SL"}, {"family": "Smeeth", "given": "Liam", "initials": "L"}, {"family": "Hayes", "given": "Joseph F", "initials": "JF"}, {"family": "Quint", "given": "Jennifer K", "initials": "JK"}, {"family": "McKee", "given": "Martin", "initials": "M"}, {"family": "Langan", "given": "Sin\u00e9ad M", "initials": "SM"}], "type": "journal-article", "published": "2021-02-00", "journal": {"title": "The Lancet Digital Health", "issn": "2589-7500", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/s2589-7500(21)00017-0", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-22T14:10:45.560Z", "modified": "2021-06-18T11:41:19.983Z"}, {"entity": "publication", "iuid": "7a750b50ba814141b855b6ad3efb4c8e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a750b50ba814141b855b6ad3efb4c8e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a750b50ba814141b855b6ad3efb4c8e"}}, "title": "Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients.", "authors": [{"family": "B\u00fclow Anderberg", "given": "Sara", "initials": "S"}, {"family": "Luther", "given": "Tomas", "initials": "T"}, {"family": "Berglund", "given": "Malin", "initials": "M"}, {"family": "Larsson", "given": "Rolf", "initials": "R"}, {"family": "Rubertsson", "given": "Sten", "initials": "S"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Cytokine", "issn": "1043-4666", "issn-l": null, "volume": "138", "issue": null, "pages": "155389"}, "abstract": "The infection caused by SARS CoV-2 has been postulated to induce a cytokine storm syndrome that results in organ failure and even death in a considerable number of patients. However, the inflammatory response in Corona virus disease-19 (Covid-19) and its potential to cause collateral organ damage has not been fully elucidated to date. This study aims to characterize the acute cytokine response in a cohort of critically ill Covid-19 patients.\r\n\r\n24 adults with PCR-confirmed Covid-19 were included at time of admission to intensive care a median of eleven days after initial symptoms. Eleven adult patients admitted for elective abdominal surgery with preoperative plasma samples served as controls. All patients were included after informed consent was obtained. 27 cytokines were quantified in plasma. The expression of inflammatory mediators was then related to routine inflammatory markers, SAPS3, SOFA score, organ failure and 30-day mortality.\r\n\r\nA general increase in cytokine expression was observed in all Covid-19 patients. A strong correlation between respiratory failure and IL-1ra, IL-4, IL-6, IL-8 and IP-10 expression was observed. Acute kidney injury development correlated well with increased levels of IL-1ra, IL-6, IL-8, IL-17a, IP-10 and MCP-1. Generally, the cohort demonstrated weaker correlations between cytokine expression and 30-day mortality out of which IL-8 showed the strongest signal in terms of mortality.\r\n\r\nThe present study found that respiratory failure, acute kidney injury and 30-day mortality in critically ill Covid-19 patients are associated with moderate increases of a broad range of inflammatory mediators at time of admission.", "doi": "10.1016/j.cyto.2020.155389", "pmid": "33348065", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1043-4666(20)30405-1"}, {"db": "pmc", "key": "PMC7833204"}], "notes": [], "created": "2020-12-22T11:23:41.897Z", "modified": "2021-06-11T14:26:41.341Z"}, {"entity": "publication", "iuid": "c5b8fd169aca45b880a478c279cf0888", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5b8fd169aca45b880a478c279cf0888.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5b8fd169aca45b880a478c279cf0888"}}, "title": "EHA/ESMO Clinical Practice Guidelines for the Management of Malignant Lymphoma: Recommendations for the Second Phase of the COVID-19 Pandemic.", "authors": [{"family": "Dreyling", "given": "Martin", "initials": "M"}, {"family": "Aurer", "given": "Igor", "initials": "I"}, {"family": "Federico", "given": "Massimo", "initials": "M"}, {"family": "Jerkeman", "given": "Mats", "initials": "M"}, {"family": "Kersten", "given": "Marie Jose", "initials": "MJ"}, {"family": "Linton", "given": "Kim", "initials": "K"}, {"family": "Mey", "given": "Ulrich", "initials": "U"}, {"family": "Tilly", "given": "Herve", "initials": "H"}, {"family": "Buske", "given": "Christian", "initials": "C"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Hemasphere", "issn": "2572-9241", "volume": "5", "issue": "2", "pages": "e529", "issn-l": null}, "abstract": null, "doi": "10.1097/HS9.0000000000000529", "pmid": "33880434", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8051991"}], "notes": [], "created": "2021-04-23T04:38:11.381Z", "modified": "2021-04-23T04:38:11.403Z"}, {"entity": "publication", "iuid": "3632e818c24f4aaf9db49ba11d5b8c07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3632e818c24f4aaf9db49ba11d5b8c07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3632e818c24f4aaf9db49ba11d5b8c07"}}, "title": "Does antipsychotic use mediate the effect of psychiatric disorders on COVID-19? - Authors' reply.", "authors": [{"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Chen", "given": "Wenwen", "initials": "W"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Lancet Healthy Longev", "issn": "2666-7568", "volume": "2", "issue": "2", "pages": "e65", "issn-l": null}, "abstract": null, "doi": "10.1016/S2666-7568(21)00007-6", "pmid": "33665643", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2666-7568(21)00007-6"}, {"db": "pmc", "key": "PMC7906648"}], "notes": [], "created": "2021-03-06T10:11:40.785Z", "modified": "2021-03-06T10:11:40.793Z"}, {"entity": "publication", "iuid": "2ec0095a0ee14c30aea469610f0c14ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ec0095a0ee14c30aea469610f0c14ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ec0095a0ee14c30aea469610f0c14ef"}}, "title": "Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19.", "authors": [{"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/305bca9e5c6c423898c272bf06ce2f2a.json"}}, {"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f28f2f6ac9648629c2d2de92fe7bb59.json"}}, {"family": "Rosell", "given": "Axel", "initials": "A", "orcid": "0000-0001-6280-0562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4da18c480a2d4c80ad6c7d1f97bbf917.json"}}, {"family": "Aguilera", "given": "Katherina", "initials": "K"}, {"family": "Parv", "given": "Kristel", "initials": "K", "orcid": "0000-0002-1238-9338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c21024fbb7f447db8879b36373e00bae.json"}}, {"family": "von Meijenfeldt", "given": "Fien A", "initials": "FA", "orcid": "0000-0003-0274-2414", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76b5cb67f6e243459441f06d41f0816c.json"}}, {"family": "Lisman", "given": "Ton", "initials": "T", "orcid": "0000-0002-3503-7140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7431e810d13c443ca5dacbf5d368e60b.json"}}, {"family": "Mackman", "given": "Nigel", "initials": "N", "orcid": "0000-0002-9170-7700", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/979eb3bfd39f407ba1f0359140d215fd.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1345-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a53a433db6f04a458e3d420f0c9995c5.json"}}, {"family": "Phillipson", "given": "Mia", "initials": "M", "orcid": "0000-0002-2387-0266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/614a4a6f69204c6287a81a79a1a7a8f1.json"}}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Arterioscler Thromb Vasc Biol", "issn": "1524-4636", "issn-l": null, "volume": "41", "issue": "2", "pages": "988-994"}, "abstract": "The full spectrum of coronavirus disease 2019 (COVID-19) infection ranges from asymptomatic to acute respiratory distress syndrome, characterized by hyperinflammation and thrombotic microangiopathy. The pathogenic mechanisms are poorly understood, but emerging evidence suggest that excessive neutrophil extracellular trap (NET) formation plays a key role in COVID-19 disease progression. Here, we evaluate if circulating markers of NETs are associated with COVID-19 disease severity and clinical outcome, as well as to markers of inflammation and in vivo coagulation and fibrinolysis. Approach and Results: One hundred six patients with COVID-19 with moderate to severe disease were enrolled shortly after hospital admission and followed for 4 months. Acute and convalescent plasma samples as well as plasma samples from 30 healthy individuals were assessed for markers of NET formation: citrullinated histone H3, cell-free DNA, NE (neutrophil elastase). We found that all plasma levels of NET markers were elevated in patients with COVID-19 relative to healthy controls, that they were associated with respiratory support requirement and short-term mortality, and declined to those found in healthy individuals 4 months post-infection. The levels of the NET markers also correlated with white blood cells, neutrophils, inflammatory cytokines, and C-reactive protein, as well as to markers of in vivo coagulation, fibrinolysis, and endothelial damage.\n\nOur findings suggest a role of NETs in COVID-19 disease progression, implicating their contribution to an immunothrombotic state. Further, we observed an association between circulating markers of NET formation and clinical outcome, demonstrating a potential role of NET markers in clinical decision-making, as well as for NETs as targets for novel therapeutic interventions in COVID-19.", "doi": "10.1161/ATVBAHA.120.315267", "pmid": "33267662", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7837697"}], "notes": [], "created": "2020-12-04T09:03:17.375Z", "modified": "2022-02-14T15:55:21.457Z"}, {"entity": "publication", "iuid": "5f2c59b02c4d48a983071ac076b60ca1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f2c59b02c4d48a983071ac076b60ca1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f2c59b02c4d48a983071ac076b60ca1"}}, "title": "COVID-19: investing in country capacity to bridge science, policy and action.", "authors": [{"family": "Kuchenm\u00fcller", "given": "Tanja", "initials": "T"}, {"family": "Reeder", "given": "John C", "initials": "JC"}, {"family": "Reveiz", "given": "Ludovic", "initials": "L"}, {"family": "Tomson", "given": "Goran", "initials": "G"}, {"family": "El-Jardali", "given": "Fadi", "initials": "F"}, {"family": "Lavis", "given": "John N", "initials": "JN"}, {"family": "Rashidian", "given": "Arash", "initials": "A"}, {"family": "Reinap", "given": "Marge", "initials": "M"}, {"family": "Grove", "given": "John T", "initials": "JT"}, {"family": "Swaminathan", "given": "Soumya", "initials": "S"}], "type": "editorial", "published": "2021-02-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "issn-l": "2059-7908", "volume": "6", "issue": "2", "pages": null}, "abstract": null, "doi": "10.1136/bmjgh-2021-005012", "pmid": "33597281", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-005012"}], "notes": [], "created": "2021-02-19T06:20:07.200Z", "modified": "2021-02-19T06:20:17.002Z"}, {"entity": "publication", "iuid": "624e15eacaa642b18cc1953db10887fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/624e15eacaa642b18cc1953db10887fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/624e15eacaa642b18cc1953db10887fd"}}, "title": "COVID-19: Opportunities for interdisciplinary research to improve care for older people in Sweden.", "authors": [{"family": "Baxter", "given": "Rebecca", "initials": "R", "orcid": "0000-0001-6595-6298", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/446ab62637de405fa4042d961cedbe36.json"}}, {"family": "Jemberie", "given": "Wossenseged Birhane", "initials": "WB", "orcid": "0000-0002-4378-6803", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e7b6e3bb364489288767124c08f43e9.json"}}, {"family": "Li", "given": "Xia", "initials": "X"}, {"family": "Naseer", "given": "Mahwish", "initials": "M"}, {"family": "Pauelsen", "given": "Mascha", "initials": "M", "orcid": "0000-0002-2510-7571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/461406e7a70a44168b097af43b4052e9.json"}}, {"family": "Shebehe", "given": "Jacques", "initials": "J", "orcid": "0000-0002-0044-0781", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/361987c728f64fbe95ef1c303417aeba.json"}}, {"family": "Viklund", "given": "Emilia W E", "initials": "EWE", "orcid": "0000-0002-5852-1381", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be19480279de4195b28af1bfe2c692ff.json"}}, {"family": "Xia", "given": "Xin", "initials": "X"}, {"family": "Zulka", "given": "Linn Elena", "initials": "LE"}, {"family": "Badache", "given": "Andreea", "initials": "A"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "volume": "49", "issue": "1", "pages": "29-32", "issn-l": "1403-4948"}, "abstract": "The emergence of COVID-19 has changed the world as we know it, arguably none more so than for older people. In Sweden, the majority of COVID-19-related fatalities have been among people aged \u2a7e70 years, many of whom were receiving health and social care services. The pandemic has illuminated aspects within the care continuum requiring evaluative research, such as decision-making processes, the structure and organisation of care, and interventions within the complex public-health system. This short communication highlights several key areas for future interdisciplinary and multi-sectorial collaboration to improve health and social care services in Sweden. It also underlines that a valid, reliable and experiential evidence base is the sine qua non for evaluative research and effective public-health systems.", "doi": "10.1177/1403494820969544", "pmid": "33161880", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7859561"}], "notes": [], "created": "2020-11-27T10:06:14.801Z", "modified": "2023-01-13T13:42:48.947Z"}, {"entity": "publication", "iuid": "7aaaa58539d848c588572b55511cd93a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7aaaa58539d848c588572b55511cd93a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7aaaa58539d848c588572b55511cd93a"}}, "title": "An analytical study of drug utilization, disease progression, and adverse events among 165 COVID-19 patients.", "authors": [{"family": "Sun", "given": "Feng", "initials": "F"}, {"family": "Kou", "given": "Hao", "initials": "H"}, {"family": "Wang", "given": "Shengfeng", "initials": "S"}, {"family": "Lu", "given": "Yun", "initials": "Y"}, {"family": "Zhao", "given": "Houyu", "initials": "H"}, {"family": "Li", "given": "Wenjing", "initials": "W"}, {"family": "Zhou", "given": "Qingxin", "initials": "Q"}, {"family": "Jiang", "given": "Qiaoli", "initials": "Q"}, {"family": "Cheng", "given": "Yinchu", "initials": "Y"}, {"family": "Yang", "given": "Kun", "initials": "K"}, {"family": "Zhuo", "given": "Lin", "initials": "L"}, {"family": "Xu", "given": "Yang", "initials": "Y"}, {"family": "Wu", "given": "Dongfang", "initials": "D"}, {"family": "Zhan", "given": "Siyan", "initials": "S"}, {"family": "Cheng", "given": "Hong", "initials": "H"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Ann Transl Med", "issn": "2305-5839", "volume": "9", "issue": "4", "pages": "306", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) epidemic has lasted for nearly 4 months by this study was conducted. We aimed to describe drug utilization, disease progression, and adverse drug events of COVID-19.\n\nA retrospective, single-center case series study enrolled 165 consecutive hospitalized COVID-19 patients who were followed up until March 25, 2020, from a designated hospital in Wuhan. Patients were grouped by a baseline degree of severity: non-severe and severe. An analytical study of drug utilization, disease progression, and adverse events (AEs) of COVID-19 was conducted.\n\nOf the 165 COVID-19 cases, antivirals, antibacterials, glucocorticoids, and traditional Chinese medicine (TCM) were administered to 92.7%, 98.8%, 68.5%, and 55.2% of patients, respectively. The total kinds of drugs administered to the severe subgroup [26, interquartile range (IQR) 18-39] were 11 more than the non-severe subgroup (15, IQR 10-24), regardless of comorbidities. The 2 most common combinations of medications in the 165 cases were 'antiviral therapy + glucocorticoids + TCM' (81, 49.1%) and 'antiviral therapy + glucocorticoids' (23, 13.9%). Compared with non-severe cases, severe cases received more glucocorticoids (88.5% vs. 66.2%, P=0.02), but less TCM (50.0% vs. 63.3%, P=0.20), and suffered a higher percentage of death (34.6% vs. 7.2%, P=0.001). At the end of the follow-up, 130 (78.8%) patients had been discharged, and 24 (14.5%) died. There were 13 patients (7.9%) who had elevated liver enzymes, and 49 patients (29.7%) presented with worsening kidney function during the follow-up.\n\nOf the 165 COVID-19 patients, the fatality rate remained high (14.5%). Drug utilization for COVID-19 was diverse and generally complied with the existing guidelines. Combination regimens containing antiviral drugs might be beneficial to assist COVID-19 recovery. Additionally, liver and kidney AEs should not be ignored.", "doi": "10.21037/atm-20-4960", "pmid": "33708933", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "atm-09-04-306"}, {"db": "pmc", "key": "PMC7944318"}], "notes": [], "created": "2021-03-17T07:19:03.452Z", "modified": "2021-04-14T04:53:53.274Z"}, {"entity": "publication", "iuid": "b7f77ec5886a47618ad2a40f1ed9e96b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b7f77ec5886a47618ad2a40f1ed9e96b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b7f77ec5886a47618ad2a40f1ed9e96b"}}, "title": "A literature survey of the robotic technologies during the COVID-19 pandemic", "authors": [{"family": "Wang", "given": "Xi Vincent", "initials": "XV"}, {"family": "Wang", "given": "Lihui", "initials": "L"}], "type": "journal-article", "published": "2021-02-00", "journal": {"title": "Journal of Manufacturing Systems", "issn": "0278-6125", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Since the late 2019, the COVID-19 pandemic has been spread all around the world. The pandemic is a critical challenge to the health and safety of the general public, the medical staff and the medical systems worldwide. It has been globally proposed to utilise robots during the pandemic, to improve the treatment of patients and leverage the load of the medical system. However, there is still a lack of detailed and systematic review of the robotic research for the pandemic, from the technologies' perspective. Thus a thorough literature survey is conducted in this research and more than 280 publications have been reviewed, with the focus on robotics during the pandemic. The main contribution of this literature survey is to answer two research questions, i.e. 1) what the main research contributions are to combat the pandemic from the robotic technologies' perspective, and 2) what the promising supporting technologies are needed during and after the pandemic to help and guide future robotics research. The current achievements of robotic technologies are reviewed and discussed in different categories, followed by the identification of the representative work's technology readiness level. The future research trends and essential technologies are then highlighted, including artificial intelligence, 5 G, big data, wireless sensor network, and human-robot collaboration.", "doi": "10.1016/j.jmsy.2021.02.005", "pmid": "33612914", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-02-22T14:09:42.828Z", "modified": "2021-03-01T10:31:09.387Z"}, {"entity": "publication", "iuid": "63a879b92bde4fafb933f2c227e84d95", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63a879b92bde4fafb933f2c227e84d95.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63a879b92bde4fafb933f2c227e84d95"}}, "title": "The screening and evaluation of potential clinically significant HIV drug combinations against the SARS-CoV-2 virus.", "authors": [{"family": "Tomi\u0107", "given": "Dra\u0161ko", "initials": "D"}, {"family": "Davidovi\u0107", "given": "Davor", "initials": "D"}, {"family": "Szasz", "given": "Attila Marcel", "initials": "AM"}, {"family": "Rezeli", "given": "Melinda", "initials": "M"}, {"family": "Pirki\u0107", "given": "Boris", "initials": "B"}, {"family": "Petrik", "given": "Jozsef", "initials": "J"}, {"family": "Vrca", "given": "Vesna Ba\u010di\u0107", "initials": "VB"}, {"family": "Jan\u0111el", "given": "Vladimir", "initials": "V"}, {"family": "Lipi\u0107", "given": "Tomislav", "initials": "T"}, {"family": "Skala", "given": "Karolj", "initials": "K"}, {"family": "Mesari\u0107", "given": "Josip", "initials": "J"}, {"family": "Peri\u0161a", "given": "Marija Milkovi\u0107", "initials": "MM"}, {"family": "\u0160ojat", "given": "Zorislav", "initials": "Z"}, {"family": "Rogina", "given": "Branka Medved", "initials": "BM"}], "type": "journal article", "published": "2021-01-30", "journal": {"title": "Inform Med Unlocked", "issn": "2352-9148", "issn-l": null, "volume": "23", "issue": null, "pages": "100529"}, "abstract": "Spike glycoprotein is essential for the reproduction of the SARS-CoV-2 virus, and its inhibition using already approved antiviral drugs may open new avenues for treatment of patients with the COVID-19 disease. Because of that we analyzed the inhibition of SARS-CoV-2 spike glycoprotein with FDA-approved antiviral drugs and their double and triple combinations. We used the Vini in silico model of cancer to perform this virtual drug screening, showing HIV drugs to be the most effective. Besides, the combination of cobicistat-abacavir-rilpivirine HIV drugs demonstrated the highest in silico efficacy of inhibiting SARS-CoV-2 spike glycoprotein. Therefore, a clinical trial of cobicistat-abacavir-rilpivirine on a limited number of COVID-19 patients in moderately severe and severe condition is warranted.", "doi": "10.1016/j.imu.2021.100529", "pmid": "33553571", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S2352-9148(21)00019-8"}, {"db": "pmc", "key": "PMC7847290"}, {"db": "URL", "key": "http://fulir.irb.hr/6161/", "description": "Results of the efficacy of FDA approved antiviral drugs on SARS-CoV-2 spike glycoprotein"}, {"db": "URL", "key": "https://github.com/draskot/Vini", "description": "The Vini in silico model of cancer"}], "notes": [], "created": "2021-02-10T18:47:44.044Z", "modified": "2021-06-21T14:53:11.203Z"}, {"entity": "publication", "iuid": "550f6ada91ba4b7184d5660c34607b68", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/550f6ada91ba4b7184d5660c34607b68.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/550f6ada91ba4b7184d5660c34607b68"}}, "title": "The Development of Swedish Military Healthcare System: Part II-Re-evaluating the Military and Civilian Healthcare Systems in Crises Through a Dialogue and Study Among Practitioners.", "authors": [{"family": "Khorram-Manesh", "given": "Amir", "initials": "A", "orcid": "0000-0002-2734-5733", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c1cf8fb45614882aa1817af7e3da375.json"}}, {"family": "Burkle", "given": "Frederick M", "initials": "FM"}, {"family": "Phattharapornjaroen", "given": "Phatthranit", "initials": "P"}, {"family": "Ahmadi Marzaleh", "given": "Milad", "initials": "M"}, {"family": "Sultan", "given": "Mohammed Al", "initials": "MA"}, {"family": "M\u00e4ntysaari", "given": "Matti", "initials": "M"}, {"family": "Carlstr\u00f6m", "given": "Eric", "initials": "E"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K", "orcid": "0000-0003-4368-6850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6bbd56fa5d243618a08005b61a9f749.json"}}, {"family": "Santamaria", "given": "Emelia", "initials": "E"}, {"family": "Comandante", "given": "John David", "initials": "JD"}, {"family": "Dobson", "given": "Robert", "initials": "R"}, {"family": "Hreckovski", "given": "Boris", "initials": "B"}, {"family": "Torgersen", "given": "Glenn-Egil", "initials": "GE"}, {"family": "Mortelmans", "given": "Luc J", "initials": "LJ"}, {"family": "de Jong", "given": "Mirjam", "initials": "M"}, {"family": "Robinson", "given": "Yohan", "initials": "Y"}], "type": "journal article", "published": "2021-01-30", "journal": {"title": "Mil Med", "issn": "1930-613X", "volume": "186", "issue": "3-4", "pages": "e442-e450", "issn-l": "0026-4075"}, "abstract": "Historical changes have transformed Sweden from being an offensive to a defensive and collaborative nation with national and international engagement, allowing it to finally achieve the ground for the civilian-military collaboration and the concept of a total defense healthcare. At the same time, with the decreasing number of international and interstate conflicts, and the military's involvement in national emergencies and humanitarian disaster relief, both the need and the role of the military healthcare system within the civilian society have been challenged. The recent impact of the COVID-19 in the USA and the necessity of military involvement have led health practitioners to anticipate and re-evaluate conditions that might exceed the civilian capacity of their own countries and the need to have collaboration with the military healthcare. This study investigated both these challenges and views from practitioners regarding the benefits of such collaboration and the manner in which it would be initiated.\n\nA primary study was conducted among responsive countries using a questionnaire created using the Nominal Group Technique. Relevant search subjects and keywords were extracted for a systematic review of the literature, according to the PRISMA model.\n\nThe 14 countries responding to the questionnaire had either a well-developed military healthcare system or units created in collaboration with the civilian healthcare. The results from the questionnaire and the literature review indicated a need for transfer of military medical knowledge and resources in emergencies to the civilian health components, which in return, facilitated training opportunities for the military staff to maintain their skills and competencies.\n\nAs the world witnesses a rapid change in the etiology of disasters and various crises, neither the military nor the civilian healthcare systems can address or manage the outcomes independently. There is an opportunity for both systems to develop future healthcare in collaboration. Rethinking education and training in war and conflict is indisputable. Collaborative educational initiatives in disaster medicine, public health and complex humanitarian emergencies, international humanitarian law, and the Geneva Convention, along with advanced training in competency-based skill sets, should be included in the undergraduate education of health professionals for the benefit of humanity.", "doi": "10.1093/milmed/usaa364", "pmid": "33135765", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7665683"}, {"db": "pii", "key": "5950402"}], "notes": [], "created": "2020-11-27T11:01:18.112Z", "modified": "2023-06-19T14:41:51.162Z"}, {"entity": "publication", "iuid": "ae2205c49d6349c8ac8f0513a453076f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ae2205c49d6349c8ac8f0513a453076f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ae2205c49d6349c8ac8f0513a453076f"}}, "title": "Resilience and mental health during the COVID-19 pandemic.", "authors": [{"family": "Verdolini", "given": "Norma", "initials": "N"}, {"family": "Amoretti", "given": "Silvia", "initials": "S"}, {"family": "Montejo", "given": "Laura", "initials": "L"}, {"family": "Garc\u00eda-Rizo", "given": "Clemente", "initials": "C"}, {"family": "Hogg", "given": "Bridget", "initials": "B"}, {"family": "Mezquida", "given": "Gisela", "initials": "G"}, {"family": "Rabelo-da-Ponte", "given": "Francisco Diego", "initials": "FD"}, {"family": "Vallespir", "given": "Catalina", "initials": "C"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Martinez-Aran", "given": "Anabel", "initials": "A"}, {"family": "Pacchiarotti", "given": "Isabella", "initials": "I"}, {"family": "Rosa", "given": "Adriane R", "initials": "AR"}, {"family": "Bernardo", "given": "Miguel", "initials": "M"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Torrent", "given": "Carla", "initials": "C"}, {"family": "Sol\u00e9", "given": "Brisa", "initials": "B"}], "type": "journal article", "published": "2021-01-29", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "volume": "283", "issue": null, "pages": "156-164", "issn-l": null}, "abstract": "Resilience is a process that allows recovery from or adaptation to adversities. The aim of this study was to evaluate state resilience during the COVID-19 pandemic in psychiatric patients (PP), unaffected relatives (UR) and community controls (CC).\n\nThis study is part of the Barcelona ResIlience Survey for Mental Health COVID-19 (BRIS-MHC) project. Logistic regression models were performed to identify mental health outcomes associated with bad state resilience and predictors of good state resilience. The association between state resilience and specific affective temperaments as well as their influence on the association between depressive symptoms and state resilience were verified.\n\nThe study recruited 898 participants that took part in the survey. The presence of depressive symptoms was a predictor of bad state resilience in PP (\u03b2=0.110, OR=1.117, p=0.028). No specific mental health outcome was associated with bad state resilience in UR and CC. Predictors of good state resilience in PP were having pursued hobbies/conducted home tasks (\u03b2=1.261, OR=3.528, p=0.044) and level of organization in the family (\u03b2=0.986, OR=2.682, p=0.008). Having a controlling family was inversely associated with good state resilience in CC (\u03b2=-1.004, OR=0.367, p=0.012). The association between bad state resilience and depressive symptoms was partially mediated by affective temperaments.\n\nParticipants self-reported their psychiatric diagnoses, their relatives' diagnoses or the absence of a psychiatric disorder, as well as their psychiatric symptoms.\n\nEnhancing resilience and coping strategies in the face of the COVID-19 pandemic might have important implications in terms of mental health outcomes.", "doi": "10.1016/j.jad.2021.01.055", "pmid": "33556749", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0165-0327(21)00072-0"}], "notes": [], "created": "2021-02-10T18:49:17.593Z", "modified": "2021-02-26T08:47:00.157Z"}, {"entity": "publication", "iuid": "44648b3c4cbd4654ac3ed76ef11c460b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44648b3c4cbd4654ac3ed76ef11c460b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44648b3c4cbd4654ac3ed76ef11c460b"}}, "title": "Epidemiological modeling in StochSS Live!", "authors": [{"family": "Jiang", "given": "Richard", "initials": "R"}, {"family": "Jacob", "given": "Bruno", "initials": "B"}, {"family": "Geiger", "given": "Matthew", "initials": "M"}, {"family": "Matthew", "given": "Sean", "initials": "S"}, {"family": "Rumsey", "given": "Bryan", "initials": "B"}, {"family": "Singh", "given": "Prashant", "initials": "P"}, {"family": "Wrede", "given": "Fredrik", "initials": "F"}, {"family": "Yi", "given": "Tau-Mu", "initials": "TM"}, {"family": "Drawert", "given": "Brian", "initials": "B"}, {"family": "Hellander", "given": "Andreas", "initials": "A"}, {"family": "Petzold", "given": "Linda", "initials": "L"}], "type": "journal article", "published": "2021-01-29", "journal": {"title": "Bioinformatics", "issn": "1367-4811", "volume": null, "issue": null, "issn-l": null}, "abstract": "We present StochSS Live!, a web-based service for modeling, simulation, and analysis of a wide range of mathematical, biological and biochemical systems. Using an epidemiological model of COVID-19, we demonstrate the power of StochSS Live! to enable researchers to quickly develop a deterministic or a discrete stochastic model, infer its parameters, and analyze the results.\n\nStochSS Live! is freely available at https://live.stochss.org/.\n\nAvailable at https://github.com/StochSS/Covid19_Modeling.", "doi": "10.1093/bioinformatics/btab061", "pmid": "33512399", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "6123781"}], "notes": [], "created": "2021-02-04T18:48:01.203Z", "modified": "2021-02-26T08:46:13.077Z"}, {"entity": "publication", "iuid": "2ff4fada5f5b4c6dbdc18860294d599a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ff4fada5f5b4c6dbdc18860294d599a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ff4fada5f5b4c6dbdc18860294d599a"}}, "title": "Clinical management of patients with genetic obesity during COVID-19 pandemic: position paper of the ESE Growth & Genetic Obesity COVID-19 Study Group and Rare Endo-ERN main thematic group on Growth and Obesity.", "authors": [{"family": "De Groot", "given": "Cornelis Jan", "initials": "CJ"}, {"family": "Poitou Bernert", "given": "Christine", "initials": "C"}, {"family": "Coupaye", "given": "Muriel", "initials": "M"}, {"family": "Clement", "given": "Karine", "initials": "K"}, {"family": "Paschou", "given": "Stavroula A", "initials": "SA"}, {"family": "Charmandari", "given": "Evangelia", "initials": "E"}, {"family": "Kanaka-Gantenbein", "given": "Christina", "initials": "C"}, {"family": "Wabitsch", "given": "Martin", "initials": "M"}, {"family": "Buddingh", "given": "Emilie P", "initials": "EP"}, {"family": "Nieuwenhuijsen", "given": "Barbara", "initials": "B"}, {"family": "Marina", "given": "Ljiljana", "initials": "L"}, {"family": "Johannsson", "given": "Gudmundur", "initials": "G"}, {"family": "Van Den Akker", "given": "E L T", "initials": "ELT"}], "type": "journal article", "published": "2021-01-29", "journal": {"title": "Endocrine", "issn": "1559-0100", "volume": null, "issue": null, "issn-l": "1355-008X"}, "abstract": "This article aims to provide guidance on prevention and treatment of COVID-19 in patients with genetic obesity. Key principals of the management of patients with genetic obesity during COVID-19 pandemic for patients that have contracted COVID-19 are to be aware of: possible adrenal insufficiency (e.g., POMC deficiency, PWS); a more severe course in patients with concomitant immunodeficiency (e.g., LEP and LEPR deficiency), although defective leptin signalling could also be protective against the pro-inflammatory phenotype of COVID-19; disease severity being masked by insufficient awareness of symptoms in syndromic obesity patients with intellectual deficit (in particular PWS); to adjust medication dose to increased body size, preferably use dosing in m2; the high risk of malnutrition in patients with Sars-Cov2 infection, even in case of obesity. Key principals of the obesity management during the pandemic are to strive for optimal obesity management and a healthy lifestyle within the possibilities of the regulations to prevent weight (re)gain and to address anxiety within consultations, since prevalence of anxiety for COVID-19 is underestimated.", "doi": "10.1007/s12020-021-02619-y", "pmid": "33512658", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s12020-021-02619-y"}], "notes": [], "created": "2021-02-01T14:17:49.638Z", "modified": "2021-02-04T18:46:35.437Z"}, {"entity": "publication", "iuid": "1dd7b99287a64aae82fbb66fa2f1ee64", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1dd7b99287a64aae82fbb66fa2f1ee64.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1dd7b99287a64aae82fbb66fa2f1ee64"}}, "title": "The angiotensin type 2 receptor agonist C21 restores respiratory function in COVID19 - a double-blind, randomized, placebo-controlled Phase 2 trial", "authors": [{"family": "Tornling", "given": "Goran", "initials": "G"}, {"family": "Batta", "given": "Rohit", "initials": "R"}, {"family": "Porter", "given": "Joanna", "initials": "J"}, {"family": "Bengtsson", "given": "Thomas", "initials": "T"}, {"family": "Parmar", "given": "Kartikeya", "initials": "K"}, {"family": "Kashiva", "given": "Reema", "initials": "R"}, {"family": "Cohrt", "given": "Anne Kartine", "initials": "AK"}, {"family": "Westergaard", "given": "Kate", "initials": "K"}, {"family": "Hallberg", "given": "Anders", "initials": "A"}, {"family": "Dalsgaard", "given": "Carl Johan", "initials": "CJ"}, {"family": "Raud", "given": "Johan", "initials": "J"}], "type": "posted-content", "published": "2021-01-28", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.01.26.21250511", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-01-29T17:30:36.012Z", "modified": "2021-04-14T04:54:19.107Z"}, {"entity": "publication", "iuid": "99f3ad7311d94bdfb953d113b4c13f07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/99f3ad7311d94bdfb953d113b4c13f07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/99f3ad7311d94bdfb953d113b4c13f07"}}, "title": "Prosociality predicts health behaviors during the COVID-19 pandemic.", "authors": [{"family": "Campos-Mercade", "given": "Pol", "initials": "P"}, {"family": "Meier", "given": "Armando N", "initials": "AN"}, {"family": "Schneider", "given": "Florian H", "initials": "FH"}, {"family": "Wengstr\u00f6m", "given": "Erik", "initials": "E"}], "type": "journal article", "published": "2021-01-28", "journal": {"title": "J Public Econ", "issn": "0047-2727", "issn-l": null, "volume": "195", "issue": null, "pages": "104367"}, "abstract": "Socially responsible behavior is crucial for slowing the spread of infectious diseases. However, economic and epidemiological models of disease transmission abstract from prosocial motivations as a driver of behaviors that impact the health of others. In an incentivized study, we show that a large majority of people are very reluctant to put others at risk for their personal benefit. Moreover, this experimental measure of prosociality predicts health behaviors during the COVID-19 pandemic, measured in a separate and ostensibly unrelated study with the same people. Prosocial individuals are more likely to follow physical distancing guidelines, stay home when sick, and buy face masks. We also find that prosociality measured two years before the pandemic predicts health behaviors during the pandemic. Our findings indicate that prosociality is a stable, long-term predictor of policy-relevant behaviors, suggesting that the impact of policies on a population may depend on the degree of prosociality.", "doi": "10.1016/j.jpubeco.2021.104367", "pmid": "33531719", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0047-2727(21)00003-7"}, {"db": "pmc", "key": "PMC7842154"}], "notes": [], "created": "2021-02-04T18:15:49.542Z", "modified": "2021-06-18T11:18:04.011Z"}, {"entity": "publication", "iuid": "6a6cc2301530439993435a8e3a9ee021", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a6cc2301530439993435a8e3a9ee021.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a6cc2301530439993435a8e3a9ee021"}}, "title": "International collaboration and covid-19: what are we doing and where are we going?", "authors": [{"family": "Bump", "given": "Jesse B", "initials": "JB"}, {"family": "Friberg", "given": "Peter", "initials": "P"}, {"family": "Harper", "given": "David R", "initials": "DR"}], "type": "journal-article", "published": "2021-01-28", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "372", "issue": null, "pages": "n180", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.n180", "pmid": "33509953", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-29T15:09:32.995Z", "modified": "2021-02-04T18:50:16.483Z"}, {"entity": "publication", "iuid": "66069e285b254e06ab7fc0f3d4e4539a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66069e285b254e06ab7fc0f3d4e4539a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66069e285b254e06ab7fc0f3d4e4539a"}}, "title": "Functional myeloid-derived suppressor cells expand in blood but not airways of COVID-19 patients and predict disease severity", "authors": [{"family": "Falck-Jones", "given": "Sara", "initials": "S"}, {"family": "Vangeti", "given": "Sindhu", "initials": "S"}, {"family": "Yu", "given": "Meng", "initials": "M"}, {"family": "Falck-Jones", "given": "Ryan", "initials": "R"}, {"family": "Cagigi", "given": "Alberto", "initials": "A"}, {"family": "Badolati", "given": "Isabella", "initials": "I"}, {"family": "Osterberg", "given": "Bjorn", "initials": "B"}, {"family": "Lautenbach", "given": "Maximilian Julius", "initials": "MJ"}, {"family": "Ahlberg", "given": "Eric", "initials": "E"}, {"family": "Lin", "given": "Ang", "initials": "A"}, {"family": "Szurgot", "given": "Inga", "initials": "I"}, {"family": "Lenart", "given": "Klara", "initials": "K"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Salde", "given": "Jorgen", "initials": "J"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "Lore", "given": "Karin", "initials": "K"}, {"family": "Farnert", "given": "Anna", "initials": "A"}, {"family": "Smed-Sorensen", "given": "Anna", "initials": "A"}], "type": "posted-content", "published": "2021-01-28", "journal": {"title": "J Clin Invest", "issn": "1558-8238", "issn-l": null, "volume": "131", "issue": "6", "pages": null}, "abstract": "The immunopathology of COVID-19 remains enigmatic, exhibiting immunodysregulation and T cell lymphopenia. Monocytic myeloid-derived suppressor cells (M-MDSC) are T cell suppressors that expand in inflammatory conditions, but their role in acute respiratory infections remains unclear. We studied blood and airways of COVID-19 patients across disease severity at multiple timepoints. M-MDSC frequencies were elevated in blood but not in nasopharyngeal or endotracheal aspirates of COVID-19 patients compared to controls. M-MDSCs isolated from COVID-19 patients suppressed T cell proliferation and IFN\u03b3 production partly via an arginase-1 (Arg-1) dependent mechanism. Furthermore, patients showed increased Arg-1 and IL-6 plasma levels. COVID-19 patients had fewer T cells, and displayed downregulated expression of the CD3\u03b6 chain. Ordinal regression showed that early M-MDSC frequency predicted subsequent disease severity. In conclusion, M-MDSCs expand in blood of COVID-19 patients, suppress T cells and strongly associate with disease severity, suggesting a role for M-MDSCs in the dysregulated COVID-19 immune response.", "doi": "10.1172/JCI144734", "pmid": "33492309", "labels": {"Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Research Area: High-throughput and high-content serology": null, "Type: Journal article": null, "Category: Health": null, "Category: Proteins": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-10-30T11:28:02.561Z", "modified": "2021-06-11T14:27:07.830Z"}, {"entity": "publication", "iuid": "ea8fff00c253452595ddbecf13dfa262", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ea8fff00c253452595ddbecf13dfa262.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ea8fff00c253452595ddbecf13dfa262"}}, "title": "Covid-19\u2014a rehearsal to build a greener and healthier society", "authors": [{"family": "Nilsson", "given": "Maria", "initials": "M"}, {"family": "Ebi", "given": "Kristie L", "initials": "KL"}, {"family": "Campbell-Lendrum", "given": "Diarmid", "initials": "D"}, {"family": "Kone", "given": "Brama", "initials": "B"}, {"family": "Friberg", "given": "Peter", "initials": "P"}], "type": "journal-article", "published": "2021-01-28", "journal": {"title": "BMJ", "issn": "1756-1833", "issn-l": null, "volume": "372", "issue": null, "pages": "n127"}, "abstract": null, "doi": "10.1136/bmj.n127", "pmid": "33509800", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-01-29T15:10:48.019Z", "modified": "2022-11-23T09:03:00.846Z"}, {"entity": "publication", "iuid": "239215138eaa431c808a711ca70c705f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/239215138eaa431c808a711ca70c705f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/239215138eaa431c808a711ca70c705f"}}, "title": "Collaborative platform trials to fight COVID-19: methodological and regulatory considerations for a better societal outcome.", "authors": [{"family": "Collignon", "given": "Olivier", "initials": "O"}, {"family": "Burman", "given": "Carl-Fredrik", "initials": "C"}, {"family": "Posch", "given": "Martin", "initials": "M"}, {"family": "Schiel", "given": "Anja", "initials": "A"}], "type": "journal article", "published": "2021-01-28", "journal": {"title": "Clin Pharmacol Ther", "issn": "1532-6535", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "For the development of COVID-19 drugs during the ongoing pandemic, speed is of essence while quality of evidence is of paramount importance. While thousands of COVID-19 trials were rapidly started, many are unlikely to provide robust statistical evidence and meet regulatory standards, e.g. because of lack of randomisation or insufficient power. This has led to an inefficient use of time and resources. With more coordination, the sheer number of patients in these trials might have generated convincing data for several investigational treatments. Collaborative platform trials, comparing several drugs to a shared control arm, are an attractive solution. Those trials can utilise a variety of adaptive design features in order to accelerate the finding of life-saving treatments. In this manuscript we discuss several possible designs, illustrate them via simulations and also discuss challenges, such as the heterogeneity of the target population, time-varying standard of care, and the potentially high number of false hypothesis rejections in Phase 2 and Phase 3. We provide corresponding regulatory perspectives on approval and reimbursement, and note that the optimal design of a platform trial will differ with our societal objective and by stakeholder. Hasty approvals may delay the development of better alternatives, while searching relentlessly for the single most efficacious treatment may indirectly diminish the number of lives saved as time is lost. We point out the need for incentivising developers to participate in collaborative evidence-generation initiatives when a positive return on investment is not met.", "doi": "10.1002/cpt.2183", "pmid": "33506495", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-01-29T15:13:01.950Z", "modified": "2021-02-04T19:05:39.855Z"}, {"entity": "publication", "iuid": "8f4a1e192b2b45d2b8217e2dfc0de36e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f4a1e192b2b45d2b8217e2dfc0de36e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f4a1e192b2b45d2b8217e2dfc0de36e"}}, "title": "To stress or not to stress: Brain-behavior-immune interaction may weaken or promote the immune response to SARS-CoV-2.", "authors": [{"family": "Peters", "given": "Eva M J", "initials": "EMJ"}, {"family": "Schedlowski", "given": "Manfred", "initials": "M"}, {"family": "Watzl", "given": "Carsten", "initials": "C"}, {"family": "Gimsa", "given": "Ulrike", "initials": "U"}], "type": "journal article", "published": "2021-01-27", "journal": {"title": "Neurobiol Stress", "issn": "2352-2895", "issn-l": null, "volume": "14", "issue": null, "pages": "100296"}, "abstract": "The COVID-19 pandemic continues to strongly affect people with health disadvantages, creating a heavy burden on medical systems and societies worldwide. Research is growing rapidly and recently revealed that stress-related factors such as socio-economic status, may also play a pivotal role. However, stress research investigating the underlying psychoneuroimmune interactions is missing. Here we address the question whether stress-associated neuroendocrine-immune mechanisms can possibly contribute to an increase in SARS-CoV-2 infections and influence the course of COVID-19 disease. Additionally, we discuss that not all forms of stress (e.g. acute versus chronic) are detrimental and that some types of stress could attenuate infection-risk and -progression. The overall aim of this review is to motivate future research efforts to clarify whether psychosocial interventions have the potential to optimize neuroendocrine-immune responses against respiratory viral infections during and beyond the COVID-19 pandemic. The current state of research on different types of stress is summarized in a comprehensive narrative review to promote a psychoneuroimmune understanding of how stress and its mediators cortisol, (nor)adrenaline, neuropeptides and neurotrophins can shape the immune defense against viral diseases. Based on this understanding, we describe how people with high psychosocial stress can be identified, which behaviors and psychosocial interventions may contribute to optimal stress management, and how psychoneuroimmune knowledge can be used to improve adequate care for COVID-19 and other patients with viral infections.", "doi": "10.1016/j.ynstr.2021.100296", "pmid": "33527083", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2352-2895(21)00004-7"}, {"db": "pmc", "key": "PMC7839386"}], "notes": [], "created": "2021-02-04T18:18:58.208Z", "modified": "2021-06-18T11:16:45.923Z"}, {"entity": "publication", "iuid": "a07ce6c124df46ce8d299b82d7921c13", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a07ce6c124df46ce8d299b82d7921c13.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a07ce6c124df46ce8d299b82d7921c13"}}, "title": "Mental Health Consequences for Healthcare Workers During the COVID-19 Pandemic: A Scoping Review to Draw Lessons for LMICs.", "authors": [{"family": "Moitra", "given": "Modhurima", "initials": "M"}, {"family": "Rahman", "given": "Muhammad", "initials": "M"}, {"family": "Collins", "given": "Pamela Y", "initials": "PY"}, {"family": "Gohar", "given": "Fatima", "initials": "F"}, {"family": "Weaver", "given": "Marcia", "initials": "M"}, {"family": "Kinuthia", "given": "John", "initials": "J"}, {"family": "R\u00f6ssler", "given": "Wulf", "initials": "W"}, {"family": "Petersen", "given": "Stefan", "initials": "S"}, {"family": "Unutzer", "given": "Jurgen", "initials": "J"}, {"family": "Saxena", "given": "Shekhar", "initials": "S"}, {"family": "Huang", "given": "Keng Yen", "initials": "KY"}, {"family": "Lai", "given": "Joanna", "initials": "J"}, {"family": "Kumar", "given": "Manasi", "initials": "M"}], "type": "journal article", "published": "2021-01-27", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "issue": null, "pages": "602614", "issn-l": "1664-0640"}, "abstract": "Background: The COVID-19 pandemic has had a significant impact on the mental health of healthcare workers (HCWs) particularly in low and middle-income countries (LMICs). This scoping review provides a summary of current evidence on the mental health consequences of COVID on HCWs. Methods: A scoping review was conducted searching PubMed and Embase for articles relevant to mental health conditions among HCWs during COVID-19. Relevant articles were screened and extracted to summarize key outcomes and findings. Results: A total of fifty-one studies were included in this review. Depressive symptoms, anxiety symptoms, psychological trauma, insomnia and sleep quality, workplace burnout and fatigue, and distress were the main outcomes reviewed. Most studies found a high number of symptoms endorsed for depression, anxiety, and other conditions. We found differences in symptoms by sex, age, and HCW role, with female, younger-aged, frontline workers, and non-physician workers being affected more than other subgroups. Conclusion: This review highlights the existing burden of mental health conditions reported by HCWs during COVID-19. It also demonstrates emerging disparities among affected HCW subgroups. This scoping review emphasizes the importance of generating high quality evidence and developing informed interventions for HCW mental health with a focus on LMICs.", "doi": "10.3389/fpsyt.2021.602614", "pmid": "33584383", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7873361"}], "notes": [], "created": "2021-02-17T14:47:10.441Z", "modified": "2021-02-26T08:47:00.126Z"}, {"entity": "publication", "iuid": "5639168d872f41ad8a36f99059c0cd8a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5639168d872f41ad8a36f99059c0cd8a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5639168d872f41ad8a36f99059c0cd8a"}}, "title": "Lung Ultrasound for Identification of Patients Requiring Invasive Mechanical Ventilation in COVID-19.", "authors": [{"family": "Seiler", "given": "Claudia", "initials": "C"}, {"family": "Klingberg", "given": "Cecilia", "initials": "C"}, {"family": "H\u00e5rdstedt", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-01-26", "journal": {"title": "J Ultrasound Med", "issn": "1550-9613", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Indication for invasive mechanical ventilation in COVID-19 pneumonia has been a major challenge. This study aimed to evaluate if lung ultrasound (LUS) can assist identification of requirement of invasive mechanical ventilation in moderate to severe COVID-19 pneumonia.\r\n\r\nBetween April 23 and November 12, 2020, hospitalized patients with moderate to severe COVID-19 (oxygen demand \u22654 L/min) were included consecutively. Lung ultrasound was performed daily until invasive mechanical ventilation (IMV-group) or spontaneous recovery (non-IMV-group). Clinical parameters and lung ultrasound findings were compared between groups, at intubation (IMV-group) and highest oxygen demand (non-IMV-group). A reference group with oxygen demand <4 L/min was examined at hospital admission.\r\n\r\nAltogether 72 patients were included: 50 study patients (IMV-group, n = 23; non-IMV-group, n = 27) and 22 reference patients. LUS-score correlated to oxygen demand (SpO 2 /FiO2 -ratio) (r = 0.728; p < 0.0001) and was higher in the IMV-group compared to the non-IMV-group (20.0 versus 18.0; p = 0.026). Based on receiver operating characteristic analysis, a LUS-score of 19.5 was identified as cut-off for requirement of invasive mechanical ventilation (area under the curve 0.68; sensitivity 56%, specificity 74%). In 6 patients, LUS identified critical coexisting conditions. Respiratory rate and oxygenation index ((SpO2 /FiO2 )/respiratory rate) \u22654.88 identified no requirement of invasive mechanical ventilation with a positive predictive value of 87% and negative predictive value of 100%.\r\n\r\nLUS-score had only a moderate diagnostic value for requirement of invasive mechanical ventilation in moderate to severe COVID-19. However, LUS proved valuable as complement to respiratory parameters in guidance of disease severity and identifying critical coexisting conditions.", "doi": "10.1002/jum.15617", "pmid": "33496362", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-29T15:37:32.985Z", "modified": "2021-06-18T11:03:00.455Z"}, {"entity": "publication", "iuid": "8a7a467b9af54956b811e2c8c056c6fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a7a467b9af54956b811e2c8c056c6fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a7a467b9af54956b811e2c8c056c6fd"}}, "title": "Community Participation Approaches for Effective National COVID-19 Pandemic Preparedness and Response: An Experience From Oman.", "authors": [{"family": "Al Siyabi", "given": "Huda", "initials": "H"}, {"family": "Al Mukhaini", "given": "Said", "initials": "S"}, {"family": "Kanaan", "given": "Mohsen", "initials": "M"}, {"family": "Al Hatmi", "given": "Sumaya", "initials": "S"}, {"family": "Al Anqoudi", "given": "Zahir", "initials": "Z"}, {"family": "Al Kalbani", "given": "Ahmed", "initials": "A"}, {"family": "Al Bahri", "given": "Zakiya", "initials": "Z"}, {"family": "Wannous", "given": "Chadia", "initials": "C"}, {"family": "Al Awaidy", "given": "Salah T", "initials": "ST"}], "type": "journal article", "published": "2021-01-26", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "616763", "issn-l": "2296-2565"}, "abstract": "Oman, like other countries in the world, was affected by the COVID-19 pandemic. Since the WHO's declaration of the pandemic, the Ministry of Health of Oman has initiated its preparedness and response to the pandemic, with community participation as one of the key components of the national preparedness and response plan. This paper is a descriptive study aims at describing the three community approaches that exist in Oman and reviewing their role in preparedness and response strategies to COVID-19 pandemic and discuss the lessons learned. Community participation approaches in Oman were translated into action during the pandemic through empowering community members, mobilizing resources, and strengthening the ownership among the local community to ensure effective advocacy, proper networking, and dissemination of information and, subsequently, actions at the level of the community. The first community participation approach is community organizations within the healthy cities and villages initiative, which facilitated networking and acted as a platform for community engagement, reviewing the health information and updating them accordingly to meet evloving demands. The second approach is Willayat (District) health committees, with their unique multi-sectoral structure, that enhanced collaboration at the state level with different community leaders and groups to develop pandemic action plans, which were implemented using available local resources. The third approach is community volunteers that remain the key information providers, particularly when physical access becomes limited due to physical distancing measures. Based on this review, we advocate to further strengthen these approaches and recommends that they are implemented for the protection and promotion of health and well-being, including for health emergencies.", "doi": "10.3389/fpubh.2020.616763", "pmid": "33575243", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7870984"}], "notes": [], "created": "2021-02-15T12:53:28.419Z", "modified": "2021-02-26T08:47:00.041Z"}, {"entity": "publication", "iuid": "a3ae0299260c4571aa064bee1cca91e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3ae0299260c4571aa064bee1cca91e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3ae0299260c4571aa064bee1cca91e8"}}, "title": "Anthropogenic Infection of Cats during the 2020 COVID-19 Pandemic.", "authors": [{"family": "Hosie", "given": "Margaret J", "initials": "MJ", "orcid": "0000-0002-4313-5023", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f40c8d7a2904c3b8fde7546efa3935f.json"}}, {"family": "Hofmann-Lehmann", "given": "Regina", "initials": "R", "orcid": "0000-0001-9750-4296", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5e8b0620f9b4c208af59a06749465c2.json"}}, {"family": "Hartmann", "given": "Katrin", "initials": "K"}, {"family": "Egberink", "given": "Herman", "initials": "H", "orcid": "0000-0001-6852-5936", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab5a969ee05c459cad512e7da7eb80b2.json"}}, {"family": "Truyen", "given": "Uwe", "initials": "U"}, {"family": "Addie", "given": "Diane D", "initials": "DD", "orcid": "0000-0001-7843-2661", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7c3e3dfc64a47758df348a154925228.json"}}, {"family": "Bel\u00e1k", "given": "S\u00e1ndor", "initials": "S"}, {"family": "Boucraut-Baralon", "given": "Corine", "initials": "C", "orcid": "0000-0002-6033-450X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/55399dde51584fb2ac0878ca1581a6c1.json"}}, {"family": "Frymus", "given": "Tadeusz", "initials": "T", "orcid": "0000-0002-9160-1455", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aee4488d842149ff9fec4d44f5bf4e21.json"}}, {"family": "Lloret", "given": "Albert", "initials": "A"}, {"family": "Lutz", "given": "Hans", "initials": "H"}, {"family": "Marsilio", "given": "Fulvio", "initials": "F", "orcid": "0000-0001-9552-1199", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc7ae4bb1210413589a00714602bed79.json"}}, {"family": "Pennisi", "given": "Maria Grazia", "initials": "MG"}, {"family": "Tasker", "given": "S\u00e9verine", "initials": "S", "orcid": "0000-0002-4059-1402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25cba4cd2417458e9d74ff2ba1d10f5b.json"}}, {"family": "Thiry", "given": "Etienne", "initials": "E"}, {"family": "M\u00f6stl", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2021-01-26", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "2", "issn-l": "1999-4915"}, "abstract": "COVID-19 is a severe acute respiratory syndrome (SARS) caused by a new coronavirus (CoV), SARS-CoV-2, which is closely related to SARS-CoV that jumped the animal-human species barrier and caused a disease outbreak in 2003. SARS-CoV-2 is a betacoronavirus that was first described in 2019, unrelated to the commonly occurring feline coronavirus (FCoV) that is an alphacoronavirus associated with feline infectious peritonitis (FIP). SARS-CoV-2 is highly contagious and has spread globally within a few months, resulting in the current pandemic. Felids have been shown to be susceptible to SARS-CoV-2 infection. Particularly in the Western world, many people live in very close contact with their pet cats, and natural infections of cats in COVID-19-positive households have been described in several countries. In this review, the European Advisory Board on Cat Diseases (ABCD), a scientifically independent board of experts in feline medicine from 11 European Countries, discusses the current status of SARS-CoV infections in cats. The review examines the host range of SARS-CoV-2 and human-to-animal transmissions, including infections in domestic and non-domestic felids, as well as mink-to-human/-cat transmission. It summarises current data on SARS-CoV-2 prevalence in domestic cats and the results of experimental infections of cats and provides expert opinions on the clinical relevance and prevention of SARS-CoV-2 infection in cats.", "doi": "10.3390/v13020185", "pmid": "33530620", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7911697"}, {"db": "pii", "key": "v13020185"}], "notes": [], "created": "2021-02-04T18:19:42.314Z", "modified": "2023-01-13T13:36:31.494Z"}, {"entity": "publication", "iuid": "30c58c30456d4cd5ba9b9340b1837eba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/30c58c30456d4cd5ba9b9340b1837eba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/30c58c30456d4cd5ba9b9340b1837eba"}}, "title": "Severe acute kidney injury associated with progression of chronic kidney disease after critical COVID-19.", "authors": [{"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Wallin", "given": "Ewa", "initials": "E"}, {"family": "Larsson", "given": "Ing-Marie", "initials": "I"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2021-01-25", "journal": {"title": "Crit Care", "issn": "1466-609X", "issn-l": "1364-8535", "volume": "25", "issue": "1", "pages": "37"}, "abstract": null, "doi": "10.1186/s13054-021-03461-4", "pmid": "33494766", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-021-03461-4"}, {"db": "ClinicalTrials.gov", "key": "NCT04474249", "description": null}], "notes": [], "created": "2021-01-28T06:54:06.133Z", "modified": "2021-06-14T14:34:29.920Z"}, {"entity": "publication", "iuid": "46ccb5a0c1e04a72b1005a9538a1ab25", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46ccb5a0c1e04a72b1005a9538a1ab25.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46ccb5a0c1e04a72b1005a9538a1ab25"}}, "title": "Elucidating the Interactions Between Heparin/Heparan Sulfate and SARS-CoV-2-Related Proteins-An Important Strategy for Developing Novel Therapeutics for the COVID-19 Pandemic.", "authors": [{"family": "Yu", "given": "Mingjia", "initials": "M"}, {"family": "Zhang", "given": "Tianji", "initials": "T"}, {"family": "Zhang", "given": "Wei", "initials": "W"}, {"family": "Sun", "given": "Qianyun", "initials": "Q"}, {"family": "Li", "given": "Hongmei", "initials": "H"}, {"family": "Li", "given": "Jin-Ping", "initials": "JP"}], "type": "journal article", "published": "2021-01-25", "journal": {"title": "Front. Mol. Biosci.", "issn": "2296-889X", "volume": "7", "issue": null, "pages": "628551", "issn-l": null}, "abstract": "Owing to the high mortality and the spread rate, the infectious disease caused by SARS-CoV-2 has become a major threat to public health and social economy, leading to over 70 million infections and 1. 6 million deaths to date. Since there are currently no effective therapeutic or widely available vaccines, it is of urgent need to look for new strategies for the treatment of SARS-CoV-2 infection diseases. Binding of a viral protein onto cell surface heparan sulfate (HS) is generally the first step in a cascade of interaction that is required for viral entry and the initiation of infection. Meanwhile, interactions of selectins and cytokines (e.g., IL-6 and TNF-\u03b1) with HS expressed on endothelial cells are crucial in controlling the recruitment of immune cells during inflammation. Thus, structurally defined heparin/HS and their mimetics might serve as potential drugs by competing with cell surface HS for the prevention of viral adhesion and modulation of inflammatory reaction. In this review, we will elaborate coronavirus invasion mechanisms and summarize the latest advances in HS-protein interactions, especially proteins relevant to the process of coronavirus infection and subsequent inflammation. Experimental and computational techniques involved will be emphasized.", "doi": "10.3389/fmolb.2020.628551", "pmid": "33569392", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7868326"}], "notes": [], "created": "2021-02-11T15:22:24.203Z", "modified": "2021-07-14T07:52:18.779Z"}, {"entity": "publication", "iuid": "c2ecaa70043f4c2dba8b717f582fc41d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2ecaa70043f4c2dba8b717f582fc41d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2ecaa70043f4c2dba8b717f582fc41d"}}, "title": "Bispecific antibody neutralizes circulating SARS-CoV-2 variants, prevents escape and protects mice from disease", "authors": [{"family": "De Gasparo", "given": "Raoul", "initials": "R"}, {"family": "Pedotti", "given": "Mattia", "initials": "M"}, {"family": "Simonelli", "given": "Luca", "initials": "L"}, {"family": "Nickl", "given": "Petr", "initials": "P"}, {"family": "Muecksch", "given": "Frauke", "initials": "F"}, {"family": "Cassaniti", "given": "Irene", "initials": "I"}, {"family": "Percivalle", "given": "Elena", "initials": "E"}, {"family": "Lorenzi", "given": "Julio C C", "initials": "JCC"}, {"family": "Mazzola", "given": "Federica", "initials": "F"}, {"family": "Magr\u00ec", "given": "Davide", "initials": "D"}, {"family": "Michalcikova", "given": "Tereza", "initials": "T"}, {"family": "Haviernik", "given": "Jan", "initials": "J"}, {"family": "Honig", "given": "Vaclav", "initials": "V"}, {"family": "Mrazkova", "given": "Blanka", "initials": "B"}, {"family": "Polakova", "given": "Natalie", "initials": "N"}, {"family": "Fortova", "given": "Andrea", "initials": "A"}, {"family": "Tureckova", "given": "Jolana", "initials": "J"}, {"family": "Iatsiuk", "given": "Veronika", "initials": "V"}, {"family": "Girolamo", "given": "Salvatore Di", "initials": "SD"}, {"family": "Palus", "given": "Martin", "initials": "M"}, {"family": "Zudova", "given": "Dagmar", "initials": "D"}, {"family": "Bednar", "given": "Petr", "initials": "P"}, {"family": "Bukova", "given": "Ivana", "initials": "I"}, {"family": "Bianchini", "given": "Filippo", "initials": "F"}, {"family": "Mehn", "given": "Dora", "initials": "D"}, {"family": "Nencka", "given": "Radim", "initials": "R"}, {"family": "Strakova", "given": "Petra", "initials": "P"}, {"family": "Pavlis", "given": "Oto", "initials": "O"}, {"family": "Rozman", "given": "Jan", "initials": "J"}, {"family": "Gioria", "given": "Sabrina", "initials": "S"}, {"family": "Camilla Sammartino", "given": "Jos\u00e8", "initials": "J"}, {"family": "Giardina", "given": "Federica", "initials": "F"}, {"family": "Gaiarsa", "given": "Stefano", "initials": "S"}, {"family": "Hammarstr\u00f6m", "given": "Qiang Pan", "initials": "QP"}, {"family": "Barnes", "given": "Christopher O", "initials": "CO"}, {"family": "Bjorkman", "given": "Pamela J", "initials": "PJ"}, {"family": "Calzolai", "given": "Luigi", "initials": "L"}, {"family": "Piralla", "given": "Antonio", "initials": "A"}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Nussenzweig", "given": "Michel C", "initials": "MC"}, {"family": "Bieniasz", "given": "Paul D", "initials": "PD"}, {"family": "Hatziioannou", "given": "Theodora", "initials": "T"}, {"family": "Prochazka", "given": "Jan", "initials": "J"}, {"family": "Sedlacek", "given": "Radislav", "initials": "R"}, {"family": "Robbiani", "given": "Davide F", "initials": "DF"}, {"family": "Ruzek", "given": "Daniel", "initials": "D"}, {"family": "Varani", "given": "Luca", "initials": "L"}], "type": "posted-content", "published": "2021-01-22", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.01.22.427567", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Proteins": null}, "xrefs": [], "notes": [], "created": "2021-06-10T03:58:04.158Z", "modified": "2021-06-10T03:58:32.998Z"}, {"entity": "publication", "iuid": "1becbf8709b94abc8098d4683f2bc703", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1becbf8709b94abc8098d4683f2bc703.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1becbf8709b94abc8098d4683f2bc703"}}, "title": "Pride and Uncertainty: A Qualitative Study of Danish Nursing Staff in Temporary COVID-19 Wards.", "authors": [{"family": "Marsaa", "given": "Kristoffer", "initials": "K"}, {"family": "Mendahl", "given": "Janni", "initials": "J"}, {"family": "Heilman", "given": "Henriette", "initials": "H"}, {"family": "Johansson", "given": "H\u00e9l\u00e8ne", "initials": "H"}, {"family": "Husum", "given": "Mette", "initials": "M"}, {"family": "Lippert", "given": "Dorthe", "initials": "D"}, {"family": "Sandholm", "given": "Niels", "initials": "N"}, {"family": "Konradsen", "given": "Hanne", "initials": "H"}], "type": "journal article", "published": "2021-01-21", "journal": {"title": "J Hosp Palliat Nurs", "issn": "1539-0705", "volume": "Publish Ahead of Print", "issue": null, "issn-l": null}, "abstract": "There is limited knowledge about the psychosocial stress among the nursing staff working on the COVID-19 wards. This article reports on the experiences of frontline health care workers as it was described to supervisors counseling the nursing staff engaged in the response to the outbreak of COVID-19. Frontline health care workers, nurses, and nurses' aides experienced major work changes. Some were transferred to the newly formed COVID-19 wards in a large Danish hospital, were given new tasks, and had to collaborate with new colleagues, while treating a new deadly and contagious disease. This study aimed to describe the reflections and experiences of the nursing staff attending supervision sessions. The palliative unit offered supervision from April 2020. A total of 9 supervision sessions were held as part of this study, and 57 nursing staff members participated in the sessions. The supervision was available to employees until the first COVID wave subsided in June 2020. During each session, supervisors took field notes and wrote field memos. The topics raised by the nursing staff during the supervision sessions ranged between pride and uncertainty. Nursing staff in COVID-19 wards were at risk of feeling an increasing burden, and there was a need for ongoing managerial attention as well as continuous visible presence and support.", "doi": "10.1097/NJH.0000000000000722", "pmid": "33496527", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "00129191-900000000-99827"}], "notes": [], "created": "2021-01-29T15:27:44.122Z", "modified": "2021-02-26T08:46:59.850Z"}, {"entity": "publication", "iuid": "6f88214beb5042b4a692919478f76efe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f88214beb5042b4a692919478f76efe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f88214beb5042b4a692919478f76efe"}}, "title": "Detection of SARS-CoV-2 using non-commercial RT-LAMP regents and raw samples.", "authors": [{"family": "Alekseenko", "given": "Alisa", "initials": "A"}, {"family": "Barrett", "given": "Donal", "initials": "D"}, {"family": "Pareja-Sanchez", "given": "Yerma", "initials": "Y"}, {"family": "Howard", "given": "Rebecca", "initials": "R"}, {"family": "Strandback", "given": "Emilia", "initials": "E"}, {"family": "Ampah-Korsah", "given": "Henry", "initials": "H"}, {"family": "Rov\u0161nik", "given": "Ur\u0161ka", "initials": "U"}, {"family": "Zuniga-Veliz", "given": "Silvia", "initials": "S"}, {"family": "Klenov", "given": "Alexander", "initials": "A"}, {"family": "Malloo", "given": "Jayshna", "initials": "J"}, {"family": "Ye", "given": "Shenglong", "initials": "S"}, {"family": "Liu", "given": "Xiyang", "initials": "X"}, {"family": "Reinius", "given": "B\u00f6jrn", "initials": "B"}, {"family": "Els\u00e4sser", "given": "Simon", "initials": "S"}, {"family": "Nyman", "given": "Tomas", "initials": "T"}, {"family": "Sandh", "given": "Gustaf", "initials": "G"}, {"family": "Yin", "given": "Xiushan", "initials": "X"}, {"family": "Pelechano", "given": "Vicent", "initials": "V"}], "type": "posted-content", "published": "2021-01-21", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "1820"}, "abstract": "RT-LAMP detection of SARS-CoV-2 has been shown as a valuable approach to scale up COVID-19 diagnostics and thus contribute to limiting the spread of the disease. Here we present the optimization of highly cost-effective in-house produced enzymes, and we benchmark their performance against commercial alternatives. We explore the compatibility between multiple DNA polymerases with high strand-displacement activity and thermostable reverse transcriptases required for RT-LAMP. We optimize reaction conditions and demonstrate their applicability using both synthetic RNA and clinical patient samples. Finally, we validated the optimized RT-LAMP assay for the detection of SARS-CoV-2 in raw nasopharyngeal samples from 184 patients. We anticipate that optimized and affordable reagents for RT-LAMP will facilitate the expansion of SARS-CoV-2 testing globally, especially in sites and settings with limited economic resources.", "doi": "10.1038/s41598-020-80352-8", "pmid": "33469065", "labels": {"Research Area: Diagnostics for virus": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Viral sequence evolution": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "URL", "key": "https://static-content.springer.com/esm/art%3A10.1038%2Fs41598-020-80352-8/MediaObjects/41598_2020_80352_MOESM3_ESM.xlsx", "description": "Numeric raw data for the amplifcation curves"}, {"db": "URL", "key": "https://static-content.springer.com/esm/art%3A10.1038%2Fs41598-020-80352-8/MediaObjects/41598_2020_80352_MOESM2_ESM.xlsx", "description": "Ct values for clinical samples from GeneXpert and all the RT-LAMP trials"}], "notes": [], "created": "2020-11-11T06:52:33.154Z", "modified": "2021-06-14T14:34:14.486Z"}, {"entity": "publication", "iuid": "91395e0a12e940bf8b5195ae8a6bcf76", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/91395e0a12e940bf8b5195ae8a6bcf76.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/91395e0a12e940bf8b5195ae8a6bcf76"}}, "title": "Should neurosurgeons continue to work in the absence of personal protective equipment during the COVID-19 era?", "authors": [{"family": "Eijkholt", "given": "Marleen", "initials": "M"}, {"family": "Hulsbergen", "given": "Alexander", "initials": "A"}, {"family": "Muskens", "given": "Ivo", "initials": "I"}, {"family": "Mathiesen", "given": "Tiit Illimar", "initials": "TI"}, {"family": "Bolger", "given": "Ciaran", "initials": "C"}, {"family": "Feldman", "given": "Zeev", "initials": "Z"}, {"family": "Kitchen", "given": "Neil", "initials": "N"}, {"family": "Sampr\u00f3n", "given": "Nicol\u00e1s", "initials": "N"}, {"family": "Sandvik", "given": "Ulrika", "initials": "U"}, {"family": "Tisell", "given": "Magnus", "initials": "M"}, {"family": "Broekman", "given": "Marike", "initials": "M"}], "type": "journal article", "published": "2021-01-20", "journal": {"title": "Acta Neurochir (Wien)", "issn": "0942-0940", "volume": null, "issue": null, "issn-l": "0001-6268"}, "abstract": "The COVID-19 pandemic has resulted in a widespread shortage of personal protective equipment (PPE). Many healthcare workers, including neurosurgeons, have expressed concern about how to safely and adequately perform their medical responsibilities in these challenging circumstances. One of these concerns revolves around the pressing question: should providers continue to work in the absence of adequate PPE? Although the first peak of the COVID-19 crisis seems to have subsided and supply of PPE has increased, concerns about insufficient PPE availability remain. Inconsistent supply, limited efficacy, and continued high demand for PPE, combined with the continued threat of a second COVID-19 wave, mean that the issues surrounding PPE availability remain unresolved, including a duty to work. This paper offers an ethical investigation of whether neurosurgeons should perform their professional responsibilities with limited availability of PPE. We evaluate ethical considerations and conflicting duties and thereby hope to facilitate providers in making a well-considered personal and moral decision about this challenging issue.", "doi": "10.1007/s00701-021-04703-8", "pmid": "33469692", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00701-021-04703-8"}], "notes": [], "created": "2021-01-22T09:12:54.748Z", "modified": "2021-01-22T09:12:54.812Z"}, {"entity": "publication", "iuid": "ac9d5631d7314b86854499c85db583c3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac9d5631d7314b86854499c85db583c3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac9d5631d7314b86854499c85db583c3"}}, "title": "Psychometric Properties of the Norwegian Version of the Fear of COVID-19 Scale.", "authors": [{"family": "Iversen", "given": "M M", "initials": "MM"}, {"family": "Norekv\u00e5l", "given": "T M", "initials": "TM"}, {"family": "Oterhals", "given": "K", "initials": "K"}, {"family": "Fadnes", "given": "L T", "initials": "LT"}, {"family": "M\u00e6land", "given": "S", "initials": "S"}, {"family": "Pakpour", "given": "A H", "initials": "AH"}, {"family": "Breivik", "given": "K", "initials": "K"}], "type": "journal article", "published": "2021-01-20", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "issn-l": null, "volume": null, "issue": null, "pages": "1-19"}, "abstract": "To examine the psychometric properties of the Norwegian version of the Fear of COVID-19 Scale (FCV-19S), randomly selected individuals from a larger registry study were invited. We assessed the reliability and validity of the instrument in a sample of 1089 adults in Norway (response rate 73%). Internal consistency measured by Cronbach's alpha (0.88) was acceptable. Omega alphaHierarchical ( \u03c9t = 0.69) was lower indicating that the general factor is less reliable, explaining 69% of the total variance. Confirmatory factor analysis indicated that the FCV-19S is not strictly unidimensional. Exploratory graph analysis and confirmatory factor analysis supported a two-factor model (cognitive and somatic fear), which were highly correlated (r = 0.84). The Norwegian version of the FCV-19S showed an underlying two-factor structure. However, the high correlation means the two latent factors (cognitive and somatic fear) act as indicators for a second-order general factor and support use of the FCV-19S sum score. The FCV-19S appears to be a valid instrument to assess fear of COVID-19 with good psychometric properties.\r\n\r\nThe online version contains supplementary material available at 10.1007/s11469-020-00454-2.", "doi": "10.1007/s11469-020-00454-2", "pmid": "33495690", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "454"}, {"db": "pmc", "key": "PMC7816751"}], "notes": [], "created": "2021-01-29T15:26:14.525Z", "modified": "2021-06-18T11:11:42.948Z"}, {"entity": "publication", "iuid": "7e73071b4d804ba5bc0bf4d6733322a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e73071b4d804ba5bc0bf4d6733322a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e73071b4d804ba5bc0bf4d6733322a1"}}, "title": "Six-Month Survival After Extracorporeal Membrane Oxygenation for Severe COVID-19.", "authors": [{"family": "Biancari", "given": "Fausto", "initials": "F"}, {"family": "Mariscalco", "given": "Giovanni", "initials": "G"}, {"family": "Dal\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Settembre", "given": "Nicla", "initials": "N"}, {"family": "Welp", "given": "Henryk", "initials": "H"}, {"family": "Perrotti", "given": "Andrea", "initials": "A"}, {"family": "Wiebe", "given": "Karsten", "initials": "K"}, {"family": "Leo", "given": "Enrico", "initials": "E"}, {"family": "Loforte", "given": "Antonio", "initials": "A"}, {"family": "Chocron", "given": "Sidney", "initials": "S"}, {"family": "Pacini", "given": "Davide", "initials": "D"}, {"family": "Juvonen", "given": "Tatu", "initials": "T"}, {"family": "Broman", "given": "L Mikael", "initials": "LM"}, {"family": "Perna", "given": "Dario Di", "initials": "DD"}, {"family": "Yusuff", "given": "Hakeem", "initials": "H"}, {"family": "Harvey", "given": "Chris", "initials": "C"}, {"family": "Mongardon", "given": "Nicolas", "initials": "N"}, {"family": "Maureira", "given": "Juan P", "initials": "JP"}, {"family": "Levy", "given": "Bruno", "initials": "B"}, {"family": "Falk", "given": "Lars", "initials": "L"}, {"family": "Ruggieri", "given": "Vito G", "initials": "VG"}, {"family": "Zipfel", "given": "Svante", "initials": "S"}, {"family": "Folliguet", "given": "Thierry", "initials": "T"}, {"family": "Fiore", "given": "Antonio", "initials": "A"}], "type": "journal article", "published": "2021-01-19", "journal": {"title": "J Cardiothorac Vasc Anesth", "issn": "1532-8422", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The authors evaluated the outcome of adult patients with coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS) requiring the use of extracorporeal membrane oxygenation (ECMO).\r\n\r\nMulticenter retrospective, observational study.\r\n\r\nTen tertiary referral university and community hospitals.\r\n\r\nPatients with confirmed severe COVID-19-related ARDS.\r\n\r\nVenovenous or venoarterial ECMO.\r\n\r\nOne hundred thirty-two patients (mean age 51.1 \u00b1 9.7 years, female 17.4%) were treated with ECMO for confirmed severe COVID-19-related ARDS. Before ECMO, the mean Sequential Organ Failure Assessment score was 10.1 \u00b1 4.4, mean pH was 7.23 \u00b1 0.09, and mean PaO 2/fraction of inspired oxygen ratio was 77 \u00b1 50 mmHg. Venovenous ECMO was adopted in 122 patients (92.4%) and venoarterial ECMO in ten patients (7.6%) (mean duration, 14.6 \u00b1 11.0 days). Sixty-three (47.7%) patients died on ECMO and 70 (53.0%) during the index hospitalization. Six-month all-cause mortality was 53.0%. Advanced age (per year, hazard ratio [HR] 1.026, 95% CI 1.000-1-052) and low arterial pH (per unit, HR 0.006, 95% CI 0.000-0.083) before ECMO were the only baseline variables associated with increased risk of six-month mortality.\r\n\r\nThe present findings suggested that about half of adult patients with severe COVID-19-related ARDS can be managed successfully with ECMO with sustained results at six months. Decreased arterial pH before ECMO was associated significantly with early mortality. Therefore, the authors hypothesized that initiation of ECMO therapy before severe metabolic derangements subset may improve survival rates significantly in these patients. These results should be viewed in the light of a strict patient selection policy and may not be replicated in patients with advanced age or multiple comorbidities.\r\n\r\nidentifier, NCT04383678.", "doi": "10.1053/j.jvca.2021.01.027", "pmid": "33573928", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1053-0770(21)00062-8"}, {"db": "ClinicalTrials.gov", "key": "NCT04383678", "description": null}], "notes": [], "created": "2021-02-15T17:22:42.437Z", "modified": "2021-06-18T10:58:38.790Z"}, {"entity": "publication", "iuid": "5ade1e95279441e0bb8db1a9d3d813fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5ade1e95279441e0bb8db1a9d3d813fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5ade1e95279441e0bb8db1a9d3d813fa"}}, "title": "Nursing students' experiences of a pedagogical transition from campus learning to distance learning using digital tools.", "authors": [{"family": "Langeg\u00e5rd", "given": "Ulrica", "initials": "U"}, {"family": "Kiani", "given": "Kiana", "initials": "K"}, {"family": "Nielsen", "given": "Susanne J", "initials": "SJ"}, {"family": "Svensson", "given": "Per-Arne", "initials": "P"}], "type": "journal article", "published": "2021-01-19", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "issn-l": null, "volume": "20", "issue": "1", "pages": "23"}, "abstract": "The use of distance education using digital tools in higher education has increased over the last decade, particularly during the COVID-19 pandemic. Therefore, this study aimed to describe and evaluate nursing students' experiences of the pedagogical transition from traditional campus based learning to distance learning using digital tools.\r\n\r\nThe nursing course Symptom and signs of illness underwent a transition from campus based education to distance learning using digital tools because of the COVID-19 pandemic. This pedagogical transition in teaching was evaluated using both quantitative and qualitative data analysis. Focus group interviews (n = 9) were analysed using qualitative content analysis to explore students' experiences of the pedagogical transition and to construct a web-based questionnaire. The questionnaire comprised 14 items, including two open-ended questions. The questionnaire was delivered to all course participants and responses were obtained from 96 of 132 students (73%). Questionnaire data were analyzed using descriptive statistics and comments from the open-ended questions were used as quotes to highlight the quantitative data.\r\n\r\nThe analysis of the focus group interviews extracted three main dimensions: didactic aspects of digital teaching, study environment, and students' own resources. Social interaction was an overall theme included in all three dimensions. Data from the questionnaire showed that a majority of students preferred campus based education and experienced deterioration in all investigated dimensions after the pedagogical transition. However, approximately one-third of the students appeared to prefer distance learning using digital tools.\r\n\r\nThe main finding was that the pedagogical transition to distance education reduced the possibility for students' social interactions in their learning process. This negatively affected several aspects of their experience of distance learning using digital tools, such as reduced motivation. However, the heterogeneity in the responses suggested that a blended learning approach may offer pedagogical benefits while maintaining an advantageous level of social interaction.", "doi": "10.1186/s12912-021-00542-1", "pmid": "33468132", "labels": {"Type: Journal article": null, "Research Area: High-throughput and high-content serology": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12912-021-00542-1"}, {"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-22T09:14:27.260Z", "modified": "2021-06-18T11:10:06.280Z"}, {"entity": "publication", "iuid": "f0e04cdd04a8471ebde402406ab8ab24", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f0e04cdd04a8471ebde402406ab8ab24.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f0e04cdd04a8471ebde402406ab8ab24"}}, "title": "Human species D adenovirus hexon capsid protein mediates cell entry through a direct interaction with CD46.", "authors": [{"family": "Persson", "given": "B David", "initials": "BD"}, {"family": "John", "given": "Lijo", "initials": "L"}, {"family": "Rafie", "given": "Karim", "initials": "K"}, {"family": "Strebl", "given": "Michael", "initials": "M"}, {"family": "Fr\u00e4ngsmyr", "given": "Lars", "initials": "L"}, {"family": "Ballmann", "given": "Monika Z", "initials": "MZ"}, {"family": "Mindler", "given": "Katja", "initials": "K"}, {"family": "Havenga", "given": "Menzo", "initials": "M"}, {"family": "Lemckert", "given": "Angelique", "initials": "A"}, {"family": "Stehle", "given": "Thilo", "initials": "T"}, {"family": "Carlson", "given": "Lars-Anders", "initials": "LA"}, {"family": "Arnberg", "given": "Niklas", "initials": "N"}], "type": "journal article", "published": "2021-01-19", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "118", "issue": "3", "issn-l": "0027-8424"}, "abstract": "Human adenovirus species D (HAdV-D) types are currently being explored as vaccine vectors for coronavirus disease 2019 (COVID-19) and other severe infectious diseases. The efficacy of such vector-based vaccines depends on functional interactions with receptors on host cells. Adenoviruses of different species are assumed to enter host cells mainly by interactions between the knob domain of the protruding fiber capsid protein and cellular receptors. Using a cell-based receptor-screening assay, we identified CD46 as a receptor for HAdV-D56. The function of CD46 was validated in infection experiments using cells lacking and overexpressing CD46, and by competition infection experiments using soluble CD46. Remarkably, unlike HAdV-B types that engage CD46 through interactions with the knob domain of the fiber protein, HAdV-D types infect host cells through a direct interaction between CD46 and the hexon protein. Soluble hexon proteins (but not fiber knob) inhibited HAdV-D56 infection, and surface plasmon analyses demonstrated that CD46 binds to HAdV-D hexon (but not fiber knob) proteins. Cryoelectron microscopy analysis of the HAdV-D56 virion-CD46 complex confirmed the interaction and showed that CD46 binds to the central cavity of hexon trimers. Finally, soluble CD46 inhibited infection by 16 out of 17 investigated HAdV-D types, suggesting that CD46 is an important receptor for a large group of adenoviruses. In conclusion, this study identifies a noncanonical entry mechanism used by human adenoviruses, which adds to the knowledge of adenovirus biology and can also be useful for development of adenovirus-based vaccine vectors.", "doi": "10.1073/pnas.2020732118", "pmid": "33384338", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "2020732118"}, {"db": "PDB", "key": "7AJP", "description": "Crystal Structure of Human Adenovirus 56 Fiber Knob"}], "notes": [], "created": "2021-01-07T11:46:55.276Z", "modified": "2021-03-08T13:05:30.572Z"}, {"entity": "publication", "iuid": "19be7cdb189c4ea5b5d140fccdbc9908", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19be7cdb189c4ea5b5d140fccdbc9908.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19be7cdb189c4ea5b5d140fccdbc9908"}}, "title": "Psychological Impact of COVID-19 Cases on Medical Staff of Beijing Xiaotangshan Hospital.", "authors": [{"family": "Fu", "given": "Yuanbo", "initials": "Y"}, {"family": "Wang", "given": "Mina", "initials": "M"}, {"family": "Zhao", "given": "Bingcong", "initials": "B"}, {"family": "Liu", "given": "Baoli", "initials": "B"}, {"family": "Sun", "given": "Jie", "initials": "J"}, {"family": "Feng", "given": "Yaohui", "initials": "Y"}, {"family": "Wang", "given": "Zhengfang", "initials": "Z"}, {"family": "Li", "given": "Qian", "initials": "Q"}, {"family": "Shi", "given": "Chunhong", "initials": "C"}, {"family": "Xuan", "given": "Yabo", "initials": "Y"}, {"family": "Long", "given": "Siqi", "initials": "S"}, {"family": "Liu", "given": "Huan", "initials": "H"}, {"family": "Chi", "given": "Tiange", "initials": "T"}, {"family": "Liao", "given": "Zehuan", "initials": "Z"}, {"family": "Li", "given": "Bin", "initials": "B"}, {"family": "Liu", "given": "Qingquan", "initials": "Q"}], "type": "journal article", "published": "2021-01-18", "journal": {"title": "Psychol Res Behav Manag", "issn": "1179-1578", "volume": "14", "issue": null, "pages": "41-47", "issn-l": null}, "abstract": "To investigate the psychological impact of cases of coronavirus disease 19 (COVID-19) on medical staff of Beijing Xiaotangshan Hospital.\n\nThe 287 online questionnaires were distributed to medical staff working at Beijing Xiaotangshan Hospital, comprising three main sections and 17 questions: basic information, current departmental position, and the 12-item General Health Questionnaire (GHQ-12). The threshold for emotional distress was defined to be a total score of 4 on the GHQ-12 and above.\n\nA total of 255 members of medical staff participating in this study presented an emotional distress rate of 17%. Members who were male, aged 50-59, married with children, positioned as doctors, and in administration were the population with the highest rate of emotional distress. Furthermore, the severity of emotional distress among those under 30 was significantly lower than those aged 30-39 and 50-59. Doctors and other occupations shared a lower level of satisfaction on routine activities compared with nurses, so did staff in the administration compared with those who were working in screening or logistic departments. Besides, males and staff of the confirmation department had more difficulty in concentrating than females and those of the screening department, respectively.\n\nMedical staff working at Xiaotangshan Hospital underwent relatively low levels of emotional distress thanks to sufficient medical and psychological preparations. However, special attention should be paid to those who were male, married with children, senior, doctors, in administration, and in the confirmation department.", "doi": "10.2147/PRBM.S287842", "pmid": "33500670", "labels": {"Type: Journal article": null, "Category: Proteins": null}, "xrefs": [{"db": "pii", "key": "287842"}, {"db": "pmc", "key": "PMC7822226"}], "notes": [], "created": "2021-01-29T15:20:19.301Z", "modified": "2021-02-26T08:47:18.761Z"}, {"entity": "publication", "iuid": "de8e43af8fbc4fce91a5e2e0a2f872d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/de8e43af8fbc4fce91a5e2e0a2f872d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/de8e43af8fbc4fce91a5e2e0a2f872d5"}}, "title": "Unrecognized risks and challenges of water as a major focus of COVID-19 spread.", "authors": [{"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}, {"family": "Burkle", "given": "Frederick M", "initials": "FM"}], "type": "journal article", "published": "2021-01-16", "journal": {"title": "J Glob Health", "issn": "2047-2986", "volume": "11", "issue": null, "pages": "03016", "issn-l": "2047-2978"}, "abstract": null, "doi": "10.7189/jogh.11.03016", "pmid": "33643626", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jogh-11-03016"}, {"db": "pmc", "key": "PMC7898659"}], "notes": [], "created": "2021-03-02T06:55:40.108Z", "modified": "2021-03-02T06:55:40.119Z"}, {"entity": "publication", "iuid": "db584bed80c945d6a6c6def84a90cf1b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db584bed80c945d6a6c6def84a90cf1b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db584bed80c945d6a6c6def84a90cf1b"}}, "title": "Sleep in Female Healthcare Workers during COVID-19: A Cross-sectional Survey Study in Sweden during the Flattening of the First Wave of the Pandemic.", "authors": [{"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J"}], "type": "journal article", "published": "2021-01-15", "journal": {"title": "Ann Am Thorac Soc", "issn": "2325-6621", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1513/AnnalsATS.202101-019RL", "pmid": "33448898", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-18T14:37:02.564Z", "modified": "2021-01-18T14:37:02.581Z"}, {"entity": "publication", "iuid": "cb790b6fefa748598789c57ca0388216", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cb790b6fefa748598789c57ca0388216.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cb790b6fefa748598789c57ca0388216"}}, "title": "Serum Renin Levels Increase With Age in Boys Resulting in Higher Renin Levels in Young Men Compared to Young Women, and Soluble Angiotensin-Converting Enzyme 2 Correlates With Renin and Body Mass Index.", "authors": [{"family": "Jehpsson", "given": "Lars", "initials": "L"}, {"family": "Sun", "given": "Jiangming", "initials": "J"}, {"family": "Nilsson", "given": "Peter M", "initials": "PM"}, {"family": "Edsfeldt", "given": "Andreas", "initials": "A"}, {"family": "Sw\u00e4rd", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2021-01-15", "journal": {"title": "Front Physiol", "issn": "1664-042X", "issn-l": null, "volume": "11", "issue": null, "pages": "622179"}, "abstract": "Background: Age, sex, and body constitution may affect the shedding of membrane bound angiotensin-converting enzyme 2 (mACE2) and lead to a relative mACE2 deficiency. However, it is unclear if differences, reflected by serum renin levels, exist in the basal renin-angiotensin-system (RAS) between children and adults, boys, and girls as well as young women and young men. Furthermore, it remains to be investigated if renin and soluble ACE2 (sACE2) levels are correlated with body mass index (BMI) in children and young adults. The aim of this observational study was to assess age-and sex differences in serum renin, and the relationship between renin, soluble angiotensin-converting enzyme 2, and body mass index in a prospectively followed population-based cohort of children which were followed into young adulthood. Study Design: We analyzed renin and sACE2 in serum in a prospectively followed population-based cohort at 9.9 (0.6) [mean (SD)] (n = 173), 11.7 (0.6) (n = 156), 14.8 (0.8) (n = 149), 18.8 (0.3) (n = 93), and 23.5 (0.7) (n = 152) years of age. Height (cm) and weight (kg) was measured and body mass index (BMI) was calculated as weight (kg)/height (m)2. Sex-related differences in renin levels were calculated using analysis of covariance, adjusted for age. Correlations were assessed by calculating the correlation coefficient (R2) using a multivariable linear mixed model. Results: Both sexes had low renin levels up to 12 years of age. Thereafter renin levels increased more in boys than in girls. Males from the age of 15 had significantly higher levels than females (p < 0.001). There was a positive linear relationship between renin and sACE2 levels in male and female subjects (p < 0.001), and between sACE2 levels and BMI in males (p < 0.001). Conclusion: Renin levels increase with age, are higher in men than in women since around puberty, and are correlated with sACE2 levels. Furthermore, sACE2 levels are correlated with body mass index in males. These findings indicate that high renin levels in males and females and a high BMI in males may activate pathways which increase the shedding of mACE2, with possible implications for the risk of severe coronavirus disease 2019.", "doi": "10.3389/fphys.2020.622179", "pmid": "33519526", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7844344"}], "notes": [], "created": "2021-02-04T18:35:07.586Z", "modified": "2021-06-18T10:52:15.052Z"}, {"entity": "publication", "iuid": "8f2208ef80cc47daaf609e804bba5feb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f2208ef80cc47daaf609e804bba5feb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f2208ef80cc47daaf609e804bba5feb"}}, "title": "Elevated Angiopoietin-2 inhibits thrombomodulin-mediated anticoagulation in critically ill COVID-19 patients", "authors": [{"family": "Hultstrom", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Fromell", "given": "Karin", "initials": "K", "orcid": "0000-0001-8905-8791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9342eb4305954aba853bdf3a8153ab67.json"}}, {"family": "Larsson", "given": "Anders", "initials": "A", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2be858ab604743b72383dfdcd14689.json"}}, {"family": "Quaggin", "given": "Susan E", "initials": "SE", "orcid": "0000-0002-3706-5727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a72116a70bfc48a69063ca0d3454123f.json"}}, {"family": "Betsholtz", "given": "Christer", "initials": "C", "orcid": "0000-0002-8494-971X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22ce9638bcd9467d812ca8adc65001d4.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Jeansson", "given": "Marie", "initials": "M", "orcid": "0000-0003-1075-8563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae2c63715b0f4a5b8127552ab84a1bf3.json"}}], "type": "posted-content", "published": "2021-01-15", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.01.13.21249429", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.17044/scilifelab.14229410.v1", "description": "Metadata record"}], "notes": [], "created": "2021-01-18T18:27:26.562Z", "modified": "2021-12-12T18:07:08.439Z"}, {"entity": "publication", "iuid": "9fa7133f2c2b4605b375cd6003754209", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9fa7133f2c2b4605b375cd6003754209.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9fa7133f2c2b4605b375cd6003754209"}}, "title": "Utilisation, Availability and Price Changes of Medicines and Protection Equipment for COVID-19 Among Selected Regions in India: Findings and Implications", "authors": [{"family": "Haque", "given": "Mainul", "initials": "M"}, {"family": "Kumar", "given": "Santosh", "initials": "S"}, {"family": "Charan", "given": "Jaykaran", "initials": "J"}, {"family": "Bhatt", "given": "Rohan", "initials": "R"}, {"family": "Islam", "given": "Salequl", "initials": "S"}, {"family": "Dutta", "given": "Siddhartha", "initials": "S"}, {"family": "Abhayanand", "given": "Jha Pallavi", "initials": "JP"}, {"family": "Sharma", "given": "Yesh", "initials": "Y"}, {"family": "Sefah", "given": "Israel", "initials": "I"}, {"family": "Kurdi", "given": "Amanj", "initials": "A"}, {"family": "Wale", "given": "Janney", "initials": "J"}, {"family": "Godman", "given": "Brian", "initials": "B"}], "type": "journal-article", "published": "2021-01-14", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "11", "issue": null, "pages": null, "issn-l": "1663-9812"}, "abstract": null, "doi": "10.3389/fphar.2020.582154", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-25T12:36:36.412Z", "modified": "2021-02-26T08:47:00.115Z"}, {"entity": "publication", "iuid": "e44cd62c93dc4ec5a51853a95aa15322", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e44cd62c93dc4ec5a51853a95aa15322.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e44cd62c93dc4ec5a51853a95aa15322"}}, "title": "The Impact of COVID-19 on In-Hospital Outcomes of ST-Segment Elevation Myocardial Infarction Patients.", "authors": [{"family": "Ayad", "given": "Sherif", "initials": "S"}, {"family": "Shenouda", "given": "Rafik", "initials": "R"}, {"family": "Henein", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2021-01-14", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "10", "issue": "2", "pages": null}, "abstract": "Primary percutaneous coronary intervention (PPCI) is one of the important clinical procedures that have been affected by the COVID-19 pandemic. In this study, we aimed to assess the incidence and impact of COVID-19 on in-hospital clinical outcome of ST elevation myocardial infarction (STEMI) patients managed with PPCI. This observational retrospective study was conducted on consecutive STEMI patients who presented to the International Cardiac Center (ICC) hospital, Alexandria, Egypt between 1 February and 31 October 2020. A group of STEMI patients presented during the same period in 2019 was also assessed (control group) and data was used for comparison. The inclusion criteria were established diagnosis of STEMI requiring PPCI.A total of 634 patients were included in the study. During the COVID-19 period, the number of PPCI procedures was reduced by 25.7% compared with previous year (mean 30.0 \u00b1 4.01 vs. 40.4 \u00b1 5.3 case/month) and the time from first medical contact to Needle (FMC-to-N) was longer (125.0 \u00b1 53.6 vs. 52.6 \u00b1 22.8 min, p = 0.001). Also, during COVID-19, the in-hospital mortality was higher (7.4 vs. 4.6%, p = 0.036) as was the incidence of re-infarction (12.2 vs. 7.7%, p = 0.041) and the need for revascularization (15.9 vs. 10.7%, p = 0.046). The incidence of heart failure, stroke, and bleeding was not different between groups, but hospital stay was longer during COVID-19 (6.85 \u00b1 4.22 vs. 3.5 \u00b1 2.3 day, p = 0.0025). Conclusion: At the ICC, COVID-19 pandemic contributed significantly to the PPCI management of STEMI patients with decreased number and delayed procedures. COVID-19 was also associated with higher in-hospital mortality, rate of re-infarction, need for revascularization, and longer hospital stay.", "doi": "10.3390/jcm10020278", "pmid": "33466588", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "jcm10020278"}], "notes": [], "created": "2021-01-22T09:16:39.182Z", "modified": "2021-06-18T10:51:57.424Z"}, {"entity": "publication", "iuid": "9ffbffb4b03446888ea96e3df6f24fa8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ffbffb4b03446888ea96e3df6f24fa8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ffbffb4b03446888ea96e3df6f24fa8"}}, "title": "Self-Perceived Changes in Physical Activity and the Relation to Life Satisfaction and Rated Physical Capacity in Swedish Adults during the COVID-19 Pandemic-A Cross Sectional Study.", "authors": [{"family": "Eek", "given": "Frida", "initials": "F"}, {"family": "Larsson", "given": "Caroline", "initials": "C"}, {"family": "Wis\u00e9n", "given": "Anita", "initials": "A"}, {"family": "Ekvall Hansson", "given": "Eva", "initials": "E"}], "type": "journal article", "published": "2021-01-14", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "2", "pages": null}, "abstract": "COVID-19 restrictions may prevent people from reaching recommended levels of physical activity (PA). This study examines self-perceived changes in the extent and intensity of PA during the COVID-19 pandemic, and the relation between perceived changes in PA and general life satisfaction and perceived physical capacity. A total of 1318 participants (mean age 47.8 SD12.6; 82.1% women) were recruited through social media in Sweden during autumn 2020. The survey included questions regarding perceived changes in PA compared to the previous year, the \"Rating of Perceived Capacity\" scale and \"Life Satisfaction Questionnaire-11\". A change in PA was reported by 65% of participants. More participants reported an increase (36%) than a decrease (29%), however a decrease in PA was significantly more often considered to be due to the pandemic. The highest odds of decreased PA was found in the oldest age group (70+ years) (OR 2.8; 95% CI 1.4-5.7). Those who reported decreased levels of PA reported lower life satisfaction and aerobic capacity than the other groups ( p > 0.001). Decreased physical activity was reported by many, but an equal share reported increased activity during the pandemic. The highest odds for decreased activity was found in the oldest group-the group that has been subjected to the strictest recommended COVID-19 restrictions in Sweden.", "doi": "10.3390/ijerph18020671", "pmid": "33466860", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph18020671"}], "notes": [], "created": "2021-01-22T09:15:10.766Z", "modified": "2021-06-18T11:03:45.303Z"}, {"entity": "publication", "iuid": "be702d32c1414faf947340a12462b206", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be702d32c1414faf947340a12462b206.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be702d32c1414faf947340a12462b206"}}, "title": "SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice", "authors": [{"family": "Tian", "given": "Jing Hui", "initials": "JH"}, {"family": "Patel", "given": "Nita", "initials": "N"}, {"family": "Haupt", "given": "Robert", "initials": "R"}, {"family": "Zhou", "given": "Haixia", "initials": "H"}, {"family": "Weston", "given": "Stuart", "initials": "S"}, {"family": "Hammond", "given": "Holly", "initials": "H"}, {"family": "Logue", "given": "James", "initials": "J"}, {"family": "Portnoff", "given": "Alyse D", "initials": "AD"}, {"family": "Norton", "given": "James", "initials": "J"}, {"family": "Guebre-Xabier", "given": "Mimi", "initials": "M"}, {"family": "Zhou", "given": "Bin", "initials": "B"}, {"family": "Jacobson", "given": "Kelsey", "initials": "K"}, {"family": "Maciejewski", "given": "Sonia", "initials": "S"}, {"family": "Khatoon", "given": "Rafia", "initials": "R"}, {"family": "Wisniewska", "given": "Malgorzata", "initials": "M"}, {"family": "Moffitt", "given": "Will", "initials": "W"}, {"family": "Kluepfel-Stahl", "given": "Stefanie", "initials": "S"}, {"family": "Ekechukwu", "given": "Betty", "initials": "B"}, {"family": "Papin", "given": "James", "initials": "J"}, {"family": "Boddapati", "given": "Sarathi", "initials": "S"}, {"family": "Jason Wong", "given": "C", "initials": "C"}, {"family": "Piedra", "given": "Pedro A", "initials": "PA"}, {"family": "Frieman", "given": "Matthew B", "initials": "MB"}, {"family": "Massare", "given": "Michael J", "initials": "MJ"}, {"family": "Fries", "given": "Louis", "initials": "L"}, {"family": "Bengtsson", "given": "Karin L\u00f6vgren", "initials": "KL"}, {"family": "Stertman", "given": "Linda", "initials": "L"}, {"family": "Ellingsworth", "given": "Larry", "initials": "L"}, {"family": "Glenn", "given": "Gregory", "initials": "G"}, {"family": "Smith", "given": "Gale", "initials": "G"}], "type": "journal-article", "published": "2021-01-14", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "372"}, "abstract": "The COVID-19 pandemic continues to spread throughout the world with an urgent need for a safe and protective vaccine to effectuate herd protection and control the spread of SARS-CoV-2. Here, we report the development of a SARS-CoV-2 subunit vaccine (NVX-CoV2373) from the full-length spike (S) protein that is stable in the prefusion conformation. NVX-CoV2373 S form 27.2-nm nanoparticles that are thermostable and bind with high affinity to the human angiotensin-converting enzyme 2 (hACE2) receptor. In mice, low-dose NVX-CoV2373 with saponin-based Matrix-M adjuvant elicit high titer anti-S IgG that blocks hACE2 receptor binding, neutralize virus, and protects against SARS-CoV-2 challenge with no evidence of vaccine-associated enhanced respiratory disease. NVX-CoV2373 also elicits multifunctional CD4 + and CD8+ T cells, CD4+ follicular helper T cells (Tfh), and antigen-specific germinal center (GC) B cells in the spleen. In baboons, low-dose levels of NVX-CoV2373 with Matrix-M was also highly immunogenic and elicited high titer anti-S antibodies and functional antibodies that block S-protein binding to hACE2 and neutralize virus infection and antigen-specific T cells. These results support the ongoing phase 1/2 clinical evaluation of the safety and immunogenicity of NVX-CoV2373 with Matrix-M (NCT04368988).", "doi": "10.1038/s41467-020-20653-8", "pmid": "33446655", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null, "Category: Vaccines": null}, "xrefs": [{"db": "URL", "key": "https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-020-20653-8/MediaObjects/41467_2020_20653_MOESM4_ESM.xlsx", "description": "Various raw data"}], "notes": [], "created": "2021-01-15T13:07:39.769Z", "modified": "2021-12-07T15:31:17.780Z"}, {"entity": "publication", "iuid": "eabd601758b541d6964027948b408314", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eabd601758b541d6964027948b408314.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eabd601758b541d6964027948b408314"}}, "title": "Real-time monitoring shows substantial excess all-cause mortality during second wave of COVID-19 in Europe, October to December 2020", "authors": [{"family": "N\u00f8rgaard", "given": "Sarah K", "initials": "SK"}, {"family": "Vestergaard", "given": "Lasse S", "initials": "LS"}, {"family": "Nielsen", "given": "Jens", "initials": "J"}, {"family": "Richter", "given": "Lukas", "initials": "L"}, {"family": "Schmid", "given": "Daniela", "initials": "D"}, {"family": "Bustos", "given": "Natalia", "initials": "N"}, {"family": "Braye", "given": "Toon", "initials": "T"}, {"family": "Athanasiadou", "given": "Maria", "initials": "M"}, {"family": "Lytras", "given": "Theodore", "initials": "T"}, {"family": "Denissov", "given": "Gleb", "initials": "G"}, {"family": "Veideman", "given": "Tatjana", "initials": "T"}, {"family": "Luomala", "given": "Oskari", "initials": "O"}, {"family": "M\u00f6tt\u00f6nen", "given": "Teemu", "initials": "T"}, {"family": "Fouillet", "given": "Anne", "initials": "A"}, {"family": "Caserio-Sch\u00f6nemann", "given": "C\u00e9line", "initials": "C"}, {"family": "an der Heiden", "given": "Matthias", "initials": "M"}, {"family": "Uphoff", "given": "Helmut", "initials": "H"}, {"family": "Gkolfinopoulou", "given": "Kassiani", "initials": "K"}, {"family": "Bobvos", "given": "Janos", "initials": "J"}, {"family": "Paldy", "given": "Anna", "initials": "A"}, {"family": "Rotem", "given": "Naama", "initials": "N"}, {"family": "Kornilenko", "given": "Irene", "initials": "I"}, {"family": "Domegan", "given": "Lisa", "initials": "L"}, {"family": "O\u2019Donnell", "given": "Joan", "initials": "J"}, {"family": "Donato", "given": "Francesca De", "initials": "FD"}, {"family": "Scortichini", "given": "Matteo", "initials": "M"}, {"family": "Hoffmann", "given": "Patrick", "initials": "P"}, {"family": "Velez", "given": "Telma", "initials": "T"}, {"family": "England", "given": "Kathleen", "initials": "K"}, {"family": "Calleja", "given": "Neville", "initials": "N"}, {"family": "van Asten", "given": "Liselotte", "initials": "L"}, {"family": "Stoeldraijer", "given": "Lenny", "initials": "L"}, {"family": "White", "given": "Richard A", "initials": "RA"}, {"family": "Paulsen", "given": "Trine H", "initials": "TH"}, {"family": "da Silva", "given": "Susana P", "initials": "SP"}, {"family": "Rodrigues", "given": "Ana P", "initials": "AP"}, {"family": "Klepac", "given": "Petra", "initials": "P"}, {"family": "Zaletel", "given": "Metka", "initials": "M"}, {"family": "Fafangel", "given": "Mario", "initials": "M"}, {"family": "Larrauri", "given": "Amparo", "initials": "A"}, {"family": "Le\u00f3n", "given": "Inmaculada", "initials": "I"}, {"family": "Farah", "given": "Ahmed", "initials": "A"}, {"family": "Galanis", "given": "Ilias", "initials": "I"}, {"family": "Junker", "given": "Christoph", "initials": "C"}, {"family": "Perisa", "given": "Damir", "initials": "D"}, {"family": "Sinnathamby", "given": "Mary", "initials": "M"}, {"family": "Andrews", "given": "Nick", "initials": "N"}, {"family": "O'Doherty", "given": "Mark G", "initials": "MG"}, {"family": "Irwin", "given": "David", "initials": "D"}, {"family": "Kennedy", "given": "Sharon", "initials": "S"}, {"family": "McMenamin", "given": "Jim", "initials": "J"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Penttinen", "given": "Pasi", "initials": "P"}, {"family": "Pukkila", "given": "Jukka", "initials": "J"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "Krause", "given": "Tyra G", "initials": "TG"}, {"family": "M\u00f8lbak", "given": "K\u00e5re", "initials": "K"}], "type": "journal-article", "published": "2021-01-14", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "2", "pages": null}, "abstract": "The European monitoring of excess mortality for public health action (EuroMOMO) network monitors weekly excess all-cause mortality in 27 European countries or subnational areas. During the first wave of the coronavirus disease (COVID-19) pandemic in Europe in spring 2020, several countries experienced extraordinarily high levels of excess mortality. Europe is currently seeing another upsurge in COVID-19 cases, and EuroMOMO is again witnessing a substantial excess all-cause mortality attributable to COVID-19.", "doi": "10.2807/1560-7917.es.2021.26.1.2002023", "pmid": "33446304", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-15T13:12:07.264Z", "modified": "2021-06-18T10:59:36.865Z"}, {"entity": "publication", "iuid": "d1739e47fac748278f5a49d715423cc6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1739e47fac748278f5a49d715423cc6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1739e47fac748278f5a49d715423cc6"}}, "title": "Rapid Assessment of the Potential Paucity and Price Increases for Suggested Medicines and Protection Equipment for COVID-19 Across Developing Countries With a Particular Focus on Africa and the Implications", "authors": [{"family": "Sefah", "given": "Israel Abebrese", "initials": "IA"}, {"family": "Ogunleye", "given": "Olayinka O", "initials": "OO"}, {"family": "Essah", "given": "Darius Obeng", "initials": "DO"}, {"family": "Opanga", "given": "Sylvia A", "initials": "SA"}, {"family": "Butt", "given": "Nadia", "initials": "N"}, {"family": "Wamaitha", "given": "Annie", "initials": "A"}, {"family": "Guantai", "given": "Anastasia Nkatha", "initials": "AN"}, {"family": "Chikowe", "given": "Ibrahim", "initials": "I"}, {"family": "Khuluza", "given": "Felix", "initials": "F"}, {"family": "Kibuule", "given": "Dan", "initials": "D"}, {"family": "Nambahu", "given": "Lahya", "initials": "L"}, {"family": "Abubakar", "given": "Abdullahi Rabiu", "initials": "AR"}, {"family": "Sani", "given": "Ibrahim Haruna", "initials": "IH"}, {"family": "Saleem", "given": "Zikria", "initials": "Z"}, {"family": "Kalungia", "given": "Aubrey C", "initials": "AC"}, {"family": "Thi Phuong", "given": "Thuy Nguyen", "initials": "TN"}, {"family": "Haque", "given": "Mainul", "initials": "M"}, {"family": "Islam", "given": "Salequl", "initials": "S"}, {"family": "Kumar", "given": "Santosh", "initials": "S"}, {"family": "Sneddon", "given": "Jacqueline", "initials": "J"}, {"family": "Wamboga", "given": "Joshua", "initials": "J"}, {"family": "Wale", "given": "Janney", "initials": "J"}, {"family": "Miljkovi\u0107", "given": "Nenad", "initials": "N"}, {"family": "Kurdi", "given": "Amanj", "initials": "A"}, {"family": "Martin", "given": "Antony P", "initials": "AP"}, {"family": "Godman", "given": "Brian", "initials": "B"}], "type": "journal-article", "published": "2021-01-14", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "11", "issue": null, "pages": null, "issn-l": "1663-9812"}, "abstract": null, "doi": "10.3389/fphar.2020.588106", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-25T12:33:08.337Z", "modified": "2021-02-26T08:47:00.209Z"}, {"entity": "publication", "iuid": "8a9fd3c3b0244e3e81860d7dc98d9a3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a9fd3c3b0244e3e81860d7dc98d9a3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a9fd3c3b0244e3e81860d7dc98d9a3d"}}, "title": "Malpractice claimed calls within the Swedish Healthcare Direct: a descriptive \u2013 comparative case study", "authors": [{"family": "Bj\u00f6rkman", "given": "Annica", "initials": "A"}, {"family": "Engstr\u00f6m", "given": "Maria", "initials": "M"}, {"family": "Winblad", "given": "Ulrika", "initials": "U"}, {"family": "Holmstr\u00f6m", "given": "Inger K", "initials": "IK"}], "type": "journal-article", "published": "2021-01-14", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "issn-l": null, "volume": "20", "issue": "1", "pages": null}, "abstract": null, "doi": "10.1186/s12912-021-00540-3", "pmid": "33446213", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-15T13:13:41.154Z", "modified": "2021-06-18T11:06:59.592Z"}, {"entity": "publication", "iuid": "5e357bc3280e4a6c8fb860e54818e86c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e357bc3280e4a6c8fb860e54818e86c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e357bc3280e4a6c8fb860e54818e86c"}}, "title": "Stress und Covid-19: Ein Narrativer Review \u00fcber neuroendokrin-immune Mechanismen, die eine Abwehr von SARS-CoV-2 verbessern k\u00f6nnten", "authors": [{"family": "Peters", "given": "Eva Milena Johanne", "initials": "EMJ"}, {"family": "Schedlowski", "given": "Manfred", "initials": "M"}, {"family": "Watzl", "given": "Carsten", "initials": "C"}, {"family": "Gimsa", "given": "Ulrike", "initials": "U"}], "type": "journal-article", "published": "2021-01-13", "journal": {"title": "Psychother Psychosom Med Psychol", "issn": "0937-2032", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1055/a-1322-3205", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-15T13:16:23.754Z", "modified": "2021-02-26T08:46:59.974Z"}, {"entity": "publication", "iuid": "f856eeca79fd4a1c8b49192f0f2fe7e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f856eeca79fd4a1c8b49192f0f2fe7e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f856eeca79fd4a1c8b49192f0f2fe7e7"}}, "title": "Distinct lung-homing receptor expression and activation profiles on NK cell and T cell subsets in COVID-19 and influenza", "authors": [{"family": "Brownlie", "given": "Demi", "initials": "D"}, {"family": "R\u00f8dahl", "given": "Inga", "initials": "I"}, {"family": "Varnaite", "given": "Renata", "initials": "R"}, {"family": "Asgeirsson", "given": "Hilmir", "initials": "H"}, {"family": "Glans", "given": "Hedvig", "initials": "H"}, {"family": "Falck-Jones", "given": "Sara", "initials": "S"}, {"family": "Vangeti", "given": "Sindhu", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Ljunggren", "given": "Hans Gustaf", "initials": "HG"}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Marquardt", "given": "Nicole", "initials": "N"}], "type": "posted-content", "published": "2021-01-13", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.01.13.426553", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-15T14:19:16.762Z", "modified": "2022-06-21T18:22:46.189Z"}, {"entity": "publication", "iuid": "c7d80c74ef2c4621be717f223c622d54", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7d80c74ef2c4621be717f223c622d54.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7d80c74ef2c4621be717f223c622d54"}}, "title": "COVID-19 after kidney transplantation: Early outcome and renal function following antiviral treatment.", "authors": [{"family": "Elec", "given": "Alina Daciana", "initials": "AD"}, {"family": "Oltean", "given": "Mihai", "initials": "M"}, {"family": "Goldis", "given": "Patricia", "initials": "P"}, {"family": "Cismaru", "given": "Cristina", "initials": "C"}, {"family": "Lupse", "given": "Mihaela", "initials": "M"}, {"family": "Muntean", "given": "Adriana", "initials": "A"}, {"family": "Elec", "given": "Florin Ioan", "initials": "FI"}], "type": "journal article", "published": "2021-01-13", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "volume": null, "issue": null, "issn-l": "1201-9712"}, "abstract": "The lack of effective COVID-19 treatments mandated the repurposing of several drugs, including antiretrovirals (ARV) and remdesivir (RDV). These compounds may induce acute kidney injuries and are not recommended in patients with poor renal function, such as kidney transplant recipients (KTx).\n\nWe reviewed the records of 42 KTx with COVID-19, some of them receiving ARV (n = 10) or RDV (n = 8) as part of the COVID-19 management. Most patients were male (71%) with a median age of 52 years and median GFR 56 mL/min and had mild (36%), moderate (19%), severe (31%), and critical (12%) disease. Subgroups (patients receiving ARV, RDV, or no antivirals) were comparable regarding patient age, comorbidities or immunosuppression.\n\nSeven patients (16,6%) died during hospitalization. Acute kidney injury was found in 24% KTx at admission. Upon discharge, eGFR increased in 32% and decreased in 39% of the KTx compared with the admission. The decrease was more prevalent in the RDV group (80%) compared with KTx without any antiviral treatment (29%) (p < 0.05). Most patients (62%) returned to baseline eGFR values within one month from discharge. The proportion was similar between the patients receiving antiviral treatment or not.\n\nKTx run a high risk of COVID-19-related renal impairment. Antivirals appear safe for use without major risks for kidney injury.", "doi": "10.1016/j.ijid.2021.01.023", "pmid": "33453396", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)00033-3"}, {"db": "URL", "key": "https://www.ijidonline.com/cms/10.1016/j.ijid.2021.01.023/attachment/10ccf84a-9c50-4457-b428-6a46ea9babe3/mmc1.docx", "description": "Patient demographics, management and outcome in 42 kidney recipients with COVID-19"}], "notes": [], "created": "2021-01-18T14:38:18.532Z", "modified": "2021-06-18T10:44:28.575Z"}, {"entity": "publication", "iuid": "87c1ab20e64f4807aae86b805119e073", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87c1ab20e64f4807aae86b805119e073.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87c1ab20e64f4807aae86b805119e073"}}, "title": "Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape", "authors": [{"family": "Koenig", "given": "Paul Albert", "initials": "PA"}, {"family": "Das", "given": "Hrishikesh", "initials": "H"}, {"family": "Liu", "given": "Hejun", "initials": "H"}, {"family": "K\u00fcmmerer", "given": "Beate M", "initials": "BM"}, {"family": "Gohr", "given": "Florian N", "initials": "FN"}, {"family": "Jenster", "given": "Lea Marie", "initials": "LM"}, {"family": "Schiffelers", "given": "Lisa D J", "initials": "LDJ"}, {"family": "Tesfamariam", "given": "Yonas M", "initials": "YM"}, {"family": "Uchima", "given": "Miki", "initials": "M"}, {"family": "Wuerth", "given": "Jennifer D", "initials": "JD"}, {"family": "Gatterdam", "given": "Karl", "initials": "K"}, {"family": "Ruetalo", "given": "Natalia", "initials": "N"}, {"family": "Christensen", "given": "Maria H", "initials": "MH"}, {"family": "Fandrey", "given": "Caroline I", "initials": "CI"}, {"family": "Normann", "given": "Sabine", "initials": "S"}, {"family": "T\u00f6dtmann", "given": "Jan M P", "initials": "JMP"}, {"family": "Pritzl", "given": "Steffen", "initials": "S"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Boos", "given": "Jannik", "initials": "J"}, {"family": "Yuan", "given": "Meng", "initials": "M"}, {"family": "Zhu", "given": "Xueyong", "initials": "X"}, {"family": "Schmid-Burgk", "given": "Jonathan L", "initials": "JL"}, {"family": "Kato", "given": "Hiroki", "initials": "H"}, {"family": "Schindler", "given": "Michael", "initials": "M"}, {"family": "Wilson", "given": "Ian A", "initials": "IA"}, {"family": "Geyer", "given": "Matthias", "initials": "M"}, {"family": "Ludwig", "given": "Kerstin U", "initials": "KU"}, {"family": "H\u00e4llberg", "given": "B Martin", "initials": "BM"}, {"family": "Wu", "given": "Nicholas C", "initials": "NC"}, {"family": "Schmidt", "given": "Florian I", "initials": "FI"}], "type": "journal-article", "published": "2021-01-12", "journal": {"title": "Science", "issn": "0036-8075", "issn-l": null, "volume": "371", "issue": "6530", "pages": "eabe6230"}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to spread with devastating consequences. For passive immunization efforts, nanobodies have size and cost advantages over conventional antibodies. Here, we generated four neutralizing nanobodies that target the receptor-binding domain of the SARS-CoV-2 spike protein. We defined two distinct binding epitopes using x-ray crystallography and cryo-electron microscopy. Based on the structures, we engineered multivalent nanobodies with more than 100-fold improved neutralizing activity than monovalent nanobodies. Biparatopic nanobody fusions suppressed the emergence of escape mutants. Several nanobody constructs neutralized through receptor-binding competition, while other monovalent and biparatopic nanobodies triggered aberrant activation of the spike fusion machinery. These premature conformational changes in the spike protein forestalled productive fusion, and rendered the virions non-infectious.", "doi": "10.1126/science.abe6230", "pmid": "33436526", "labels": {"Type: Journal article": null, "Funder: H2020": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Imaging": null, "Category: Proteins": null}, "xrefs": [{"db": "PDB", "key": "7KN5", "description": "Crystal structure of SARS-CoV-2 RBD complexed with nanobodies VHH E and U"}, {"db": "PDB", "key": "7KN6", "description": "Crystal structure of SARS-CoV-2 RBD complexed with nanobody VHH V and antibody Fab CC12.3"}, {"db": "PDB", "key": "7KN7", "description": "Crystal structure of SARS-CoV-2 RBD complexed with nanobody VHH W and antibody Fab CC12.3"}, {"db": "URL", "key": "https://www.ebi.ac.uk/pdbe/entry/emdb/EMD-23018", "description": "EMD-23018"}, {"db": "PDB", "key": "7KSG", "description": "SARS-CoV-2 spike in complex with nanobodies E"}, {"db": "PDB", "key": "7B14", "description": "Nanobody E bound to Spike-RBD in a localized reconstruction."}, {"db": "PDB", "key": "7B11", "description": "SARS-CoV-spike with two RBDs up bound to VHH V on all RBDs"}, {"db": "PDB", "key": "7B18", "description": "SARS-CoV-spike bound to two neutralising nanobodies"}, {"db": "PDB", "key": "7B17", "description": "SARS-CoV-spike RBD bound to two neutralising nanobodies"}], "notes": [], "created": "2021-01-15T13:19:46.751Z", "modified": "2021-02-26T08:47:18.838Z"}, {"entity": "publication", "iuid": "2e3218c29d0d4fcc9d2c729ae25a3dd4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e3218c29d0d4fcc9d2c729ae25a3dd4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e3218c29d0d4fcc9d2c729ae25a3dd4"}}, "title": "Life with Parkinson\u2019s Disease During the COVID-19 Pandemic: The Pressure Is \u201cOFF\u201d", "authors": [{"family": "H\u00d8rmann Thomsen", "given": "Trine", "initials": "T"}, {"family": "Wallerstedt", "given": "Susanna M", "initials": "SM"}, {"family": "Winge", "given": "Kristian", "initials": "K"}, {"family": "Bergquist", "given": "Filip", "initials": "F"}], "type": "journal-article", "published": "2021-01-12", "journal": {"title": "JPD", "issn": "1877-7171", "volume": null, "issue": null, "pages": "1-5", "issn-l": null}, "abstract": "People with Parkinson's disease (PwP) have been suggested to be more vulnerable to negative psychological and psycho-social effects of the COVID-19 pandemic. Our aim was to assess the potential impact of the COVID-19 pandemic in PwP. A Danish/Swedish cohort of 67 PwP was analysed. Health-related quality of life (HRQL), depression, anxiety, apathy, sleep and motor symptom-scores were included in the analysis. Additionally, the Danish participants provided free-text descriptions of life during the pandemic. Overall, the participants reported significantly better HRQL during the COVID-19 period compared with before. Reduced social pressure may be part of the explanation. Despite worsened anxiety, night sleep improved.", "doi": "10.3233/jpd-202342", "pmid": "33459663", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-20T14:56:06.163Z", "modified": "2021-02-26T08:45:47.993Z"}, {"entity": "publication", "iuid": "07fb542a0f25476990091489eaf9e0db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07fb542a0f25476990091489eaf9e0db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07fb542a0f25476990091489eaf9e0db"}}, "title": "High Rates of COVID-19 Vaccine Hesitancy and Its Association with Conspiracy Beliefs: A Study in Jordan and Kuwait among Other Arab Countries", "authors": [{"family": "Sallam", "given": "Malik", "initials": "M"}, {"family": "Dababseh", "given": "Deema", "initials": "D"}, {"family": "Eid", "given": "Huda", "initials": "H"}, {"family": "Al-Mahzoum", "given": "Kholoud", "initials": "K"}, {"family": "Al-Haidar", "given": "Ayat", "initials": "A"}, {"family": "Taim", "given": "Duaa", "initials": "D"}, {"family": "Yaseen", "given": "Alaa", "initials": "A"}, {"family": "Ababneh", "given": "Nidaa A", "initials": "NA"}, {"family": "Bakri", "given": "Faris G", "initials": "FG"}, {"family": "Mahafzah", "given": "Azmi", "initials": "A"}], "type": "journal-article", "published": "2021-01-12", "journal": {"title": "Vaccines", "issn": "2076-393X", "issn-l": null, "volume": "9", "issue": "1", "pages": "42"}, "abstract": null, "doi": "10.3390/vaccines9010042", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-15T13:13:59.416Z", "modified": "2021-06-18T10:01:39.292Z"}, {"entity": "publication", "iuid": "87a9168f79af44dfa5c06f3be54a5e14", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87a9168f79af44dfa5c06f3be54a5e14.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87a9168f79af44dfa5c06f3be54a5e14"}}, "title": "Cytoplasmic short linear motifs in ACE2 and integrin \u03b23 link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy.", "authors": [{"family": "Kliche", "given": "Johanna", "initials": "J", "orcid": "0000-0003-3179-4635", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18ffcca5dbaa45bcad0d1385df5d0c12.json"}}, {"family": "Kuss", "given": "Hanna", "initials": "H", "orcid": "0000-0001-8948-7035", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/395062f1a0fe486cbfc1d025fa60bdad.json"}}, {"family": "Ali", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-8858-6776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0515e4fd072741b0a01456320bbf73de.json"}}, {"family": "Ivarsson", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-7081-3846", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b3cf0504a1b476f906c4b3e22b05d5a.json"}}], "type": "journal article", "published": "2021-01-12", "journal": {"title": "Sci Signal", "issn": "1937-9145", "issn-l": null, "volume": "14", "issue": "665", "pages": null}, "abstract": "The spike protein of SARS-CoV-2 binds the angiotensin-converting enzyme 2 (ACE2) on the host cell surface and subsequently enters host cells through receptor-mediated endocytosis. Additional cell receptors may be directly or indirectly involved, including integrins. The cytoplasmic tails of ACE2 and integrins contain several predicted short linear motifs (SLiMs) that may facilitate internalization of the virus as well as its subsequent propagation through processes such as autophagy. Here, we measured the binding affinity of predicted interactions between SLiMs in the cytoplasmic tails of ACE2 and integrin \u03b23 with proteins that mediate endocytic trafficking and autophagy. We validated that a class I PDZ-binding motif mediated binding of ACE2 to the scaffolding proteins SNX27, NHERF3, and SHANK, and that a binding site for the clathrin adaptor AP2 \u03bc2 in ACE2 overlaps with a phospho-dependent binding site for the SH2 domains of Src family tyrosine kinases. Furthermore, we validated that an LC3-interacting region (LIR) in integrin \u03b23 bound to the ATG8 domains of the autophagy receptors MAP1LC3 and GABARAP in a manner enhanced by LIR-adjacent phosphorylation. Our results provide molecular links between cell receptors and mediators of endocytosis and autophagy that may facilitate viral entry and propagation.", "doi": "10.1126/scisignal.abf1117", "pmid": "33436498", "labels": {"Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7928716"}, {"db": "pii", "key": "14/665/eabf1117"}], "notes": [], "created": "2021-01-08T08:52:49.399Z", "modified": "2023-06-19T15:00:19.344Z"}, {"entity": "publication", "iuid": "7cea9ce7584b467692597202c1fba7d1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7cea9ce7584b467692597202c1fba7d1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7cea9ce7584b467692597202c1fba7d1"}}, "title": "CSF Biomarkers in Patients With COVID-19 and Neurologic Symptoms: A Case Series.", "authors": [{"family": "Ed\u00e9n", "given": "Arvid", "initials": "A"}, {"family": "Kanberg", "given": "Nelly", "initials": "N"}, {"family": "Gostner", "given": "Johanna", "initials": "J", "orcid": "0000-0003-1532-5177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42618c3aa97e473581a66529c2a8b4b2.json"}}, {"family": "Fuchs", "given": "Dietmar", "initials": "D"}, {"family": "Hagberg", "given": "Lars", "initials": "L"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Price", "given": "Richard W", "initials": "RW"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "case reports", "published": "2021-01-12", "journal": {"title": "Neurology", "issn": "1526-632X", "issn-l": "0028-3878", "volume": "96", "issue": "2", "pages": "e294-e300"}, "abstract": "To explore whether hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and neurologic symptoms have evidence of CNS infection, inflammation, and injury using CSF biomarker measurements.\n\nWe assessed CSF SARS-CoV-2 RNA along with CSF biomarkers of intrathecal inflammation (CSF white blood cell count, neopterin, \u03b22-microglobulin, and immunoglobulin G index), blood-brain barrier integrity (albumin ratio), and axonal injury (CSF neurofilament light chain protein [NfL]) in 6 patients with moderate to severe coronavirus disease 2019 (COVID-19) and neurologic symptoms who had undergone a diagnostic lumbar puncture. Neurologic symptoms and signs included features of encephalopathies (4 of 6), suspected meningitis (1 of 6), and dysgeusia (1 of 6). SARS-CoV-2 infection was confirmed by real-time PCR analysis of nasopharyngeal swabs.\n\nSARS-CoV-2 RNA was detected in the plasma of 2 patients (cycle threshold [Ct] value 35.0-37.0) and in CSF at low levels (Ct 37.2, 38.0, 39.0) in 3 patients in 1 but not in a second real-time PCR assay. CSF neopterin (median 43.0 nmol/L) and \u03b22-microglobulin (median 3.1 mg/L) were increased in all. Median immunoglobulin G index (0.39), albumin ratio (5.35), and CSF white blood cell count (<3 cells/\u00b5L) were normal in all, while CSF NfL was elevated in 2 patients.\n\nOur results in patients with COVID-19 and neurologic symptoms suggest an unusual pattern of marked CSF inflammation in which soluble markers were increased but white cell response and other immunologic features typical of CNS viral infections were absent. While our initial hypothesis centered on CNS SARS-CoV-2 invasion, we could not convincingly detect SARS-CoV-2 as the underlying driver of CNS inflammation. These features distinguish COVID-19 CSF from other viral CNS infections and raise fundamental questions about the CNS pathobiology of SARS-CoV-2 infection.", "doi": "10.1212/WNL.0000000000010977", "pmid": "33004602", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "WNL.0000000000010977"}], "notes": [], "created": "2020-10-28T09:06:39.849Z", "modified": "2023-06-19T14:46:31.151Z"}, {"entity": "publication", "iuid": "aaef86b6c7a14c1abe87aa0aef4e82b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aaef86b6c7a14c1abe87aa0aef4e82b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aaef86b6c7a14c1abe87aa0aef4e82b1"}}, "title": "Stimulating the Resolution of Inflammation Through Omega-3 Polyunsaturated Fatty Acids in COVID-19: Rationale for the COVID-Omega-F Trial.", "authors": [{"family": "Arnardottir", "given": "Hildur", "initials": "H"}, {"family": "Pawelzik", "given": "Sven-Christian", "initials": "SC", "orcid": "0000-0001-8704-6607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5249b23453a347a883217f7c90cfeb00.json"}}, {"family": "\u00d6hlund Wistbacka", "given": "Ulf", "initials": "U"}, {"family": "Artiach", "given": "Gonzalo", "initials": "G"}, {"family": "Hofmann", "given": "Robin", "initials": "R"}, {"family": "Reinholdsson", "given": "Ingalill", "initials": "I"}, {"family": "Braunschweig", "given": "Frieder", "initials": "F"}, {"family": "Tornvall", "given": "Per", "initials": "P"}, {"family": "Religa", "given": "Dorota", "initials": "D"}, {"family": "B\u00e4ck", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-01-11", "journal": {"title": "Front Physiol", "issn": "1664-042X", "volume": "11", "issue": null, "pages": "624657", "issn-l": null}, "abstract": "Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). SARS-CoV-2 triggers an immune response with local inflammation in the lung, which may extend to a systemic hyperinflammatory reaction. Excessive inflammation has been reported in severe cases with respiratory failure and cardiovascular complications. In addition to the release of cytokines, referred to as cytokine release syndrome or \"cytokine storm,\" increased pro-inflammatory lipid mediators derived from the omega-6 polyunsaturated fatty acid (PUFA) arachidonic acid may cause an \"eicosanoid storm,\" which contributes to the uncontrolled systemic inflammation. Specialized pro-resolving mediators, which are derived from omega-3 PUFA, limit inflammatory reactions by an active process called resolution of inflammation. Here, the rationale for omega-3 PUFA supplementation in COVID-19 patients is presented along with a brief overview of the study protocol for the trial \"Resolving Inflammatory Storm in COVID-19 Patients by Omega-3 Polyunsaturated Fatty Acids - A single-blind, randomized, placebo-controlled feasibility study\" (COVID-Omega-F). EudraCT: 2020-002293-28; clinicaltrials.gov: NCT04647604.", "doi": "10.3389/fphys.2020.624657", "pmid": "33505321", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC7830247"}, {"db": "ClinicalTrials.gov", "key": "NCT04647604"}], "notes": [], "created": "2021-01-29T15:12:20.798Z", "modified": "2023-06-19T15:19:23.375Z"}, {"entity": "publication", "iuid": "0ab1e98bc6c24f64ad568682517aee4f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ab1e98bc6c24f64ad568682517aee4f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ab1e98bc6c24f64ad568682517aee4f"}}, "title": "Impact on physical and mental health among medical personnel in Wuhan during COVID-19 outbreak: a cluster analysis.", "authors": [{"family": "Gao", "given": "Jing", "initials": "J"}, {"family": "Li", "given": "Jing", "initials": "J"}, {"family": "Han", "given": "Xia", "initials": "X"}, {"family": "Yuan", "given": "Yuan", "initials": "Y"}, {"family": "Li", "given": "Chuan-Xing", "initials": "CX"}, {"family": "Zhang", "given": "Dong-Quan", "initials": "DQ"}], "type": "journal article", "published": "2021-01-11", "journal": {"title": "Int J Med Sci", "issn": "1449-1907", "volume": "18", "issue": "5", "pages": "1185-1188", "issn-l": null}, "abstract": "Background: Increased stress among medical personnel had been reported in previous virus outbreaks. The novel coronavirus disease (COVID-19) emerged in December 2019, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). No qualitative assessment has yet described the physical and mental health conditions of frontline medical personnel in the COVID-19 outbreaks. Methods: Here, 251 frontline medical personnel involved in COVID-19 missions completed electronic questionnaires, consisting of 31 categorical variables related to their physical and mental health status, medical history and environmental conditions. We constructed a correlation amongst these variables through pairwise Kendall rank correlation coefficient test. Then, clusters of highly correlated variables were identified using the leading eigenvector. Finally, we used the network and clusters to clarify the correlations amongst variables. Results: This qualitative study identified the six clusters. Cluster 1 was characterized by skin allergy. Cluster 2 was predominantly associated with anxiety. Cluster 3 consisted mostly of respiratory symptoms. The participants in cluster 4 had medical history. Cluster 5 and cluster 6 were characterized by disinfection and demography, respectively. Finally, we revealed three major findings. First, more than 80% of medical personnel worry about COVID-19-related infection and experience newly appearing anxiety (56.2%), airway or heart symptoms (34.3%) and skin allergies (20.3%). Second, COVID-19-related worry significantly associates with all variables in the anxiety and respiratory symptom clusters. Third, new-onset skin allergies did not associate with either disinfection or anxiety, but did associate with a previous history of allergies. Conclusions: COVID-19-related worry leads to physical and mental health problems amongst medical personnel. Effective responses and interventions could relieve a series of new-onset physical and mental health problems.", "doi": "10.7150/ijms.51315", "pmid": "33526979", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijmsv18p1185"}, {"db": "pmc", "key": "PMC7847622"}], "notes": [], "created": "2021-02-04T18:21:47.061Z", "modified": "2021-02-26T08:46:59.832Z"}, {"entity": "publication", "iuid": "040cdb5e913f4417ba0f2d8f35bfc266", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/040cdb5e913f4417ba0f2d8f35bfc266.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/040cdb5e913f4417ba0f2d8f35bfc266"}}, "title": "Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection.", "authors": [{"family": "Monteil", "given": "Vanessa", "initials": "V", "orcid": "0000-0002-2652-5695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8ba8a0b1af6423b9cba0fc4bb3177cd.json"}}, {"family": "Dyczynski", "given": "Matheus", "initials": "M", "orcid": "0000-0002-7650-3574", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/85f093ab4ac24580810b0ea22f1dd0c6.json"}}, {"family": "Lauschke", "given": "Volker M", "initials": "VM", "orcid": "0000-0002-1140-6204", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe2e21e55733492996018d1a5b037969.json"}}, {"family": "Kwon", "given": "Hyesoo", "initials": "H"}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G"}, {"family": "Youhanna", "given": "Sonia", "initials": "S", "orcid": "0000-0002-9376-8478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b777b2409fb34cd0b0d154bf2aab5d5d.json"}}, {"family": "Zhang", "given": "Haibo", "initials": "H", "orcid": "0000-0002-1714-3038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1fe0f99f8a74a87a4772166d46744de.json"}}, {"family": "Slutsky", "given": "Arthur S", "initials": "AS", "orcid": "0000-0002-6063-3876", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f9a9cd065c74b71960c62e55caf6b58.json"}}, {"family": "Hurtado Del Pozo", "given": "Carmen", "initials": "C"}, {"family": "Horn", "given": "Moritz", "initials": "M", "orcid": "0000-0002-5324-7256", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a000f2fad24410281396504ca78b6d8.json"}}, {"family": "Montserrat", "given": "Nuria", "initials": "N", "orcid": "0000-0002-1603-1755", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d4cdae2b5b34dd798f73faa0a3aa391.json"}}, {"family": "Penninger", "given": "Josef M", "initials": "JM", "orcid": "0000-0002-8194-3777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e56aaa008524272bf252df804e06991.json"}}, {"family": "Mirazimi", "given": "Ali", "initials": "A", "orcid": "0000-0003-2371-6055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0651be47429c4e5880a13b839d04fe1d.json"}}], "type": "journal article", "published": "2021-01-11", "journal": {"title": "EMBO Mol Med", "issn": "1757-4684", "issn-l": "1757-4676", "volume": "13", "issue": "1", "pages": "e13426"}, "abstract": "There is a critical need for safe and effective drugs for COVID-19. Only remdesivir has received authorization for COVID-19 and has been shown to improve outcomes but not decrease mortality. However, the dose of remdesivir is limited by hepatic and kidney toxicity. ACE2 is the critical cell surface receptor for SARS-CoV-2. Here, we investigated additive effect of combination therapy using remdesivir with recombinant soluble ACE2 (high/low dose) on Vero E6 and kidney organoids, targeting two different modalities of SARS-CoV-2 life cycle: cell entry via its receptor ACE2 and intracellular viral RNA replication. This combination treatment markedly improved their therapeutic windows against SARS-CoV-2 in both models. By using single amino-acid resolution screening in haploid ES cells, we report a singular critical pathway required for remdesivir toxicity, namely, Adenylate Kinase 2. The data provided here demonstrate that combining two therapeutic modalities with different targets, common strategy in HIV treatment, exhibit strong additive effects at sub-toxic concentrations. Our data lay the groundwork for the study of combinatorial regimens in future COVID-19 clinical trials.", "doi": "10.15252/emmm.202013426", "pmid": "33179852", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: H2020": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC7799356"}], "notes": [], "created": "2020-11-19T19:45:22.452Z", "modified": "2023-06-19T14:43:00.181Z"}, {"entity": "publication", "iuid": "bc16a7b8aa2048cbbe80b22f956dbe5f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bc16a7b8aa2048cbbe80b22f956dbe5f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bc16a7b8aa2048cbbe80b22f956dbe5f"}}, "title": "[Temporal variations in excess mortality during phase 1 and phase 2 of the COVID-19 epidemic in Italy].", "authors": [{"family": "Michelozzi", "given": "Paola", "initials": "P"}, {"family": "De' Donato", "given": "Francesca", "initials": "F"}, {"family": "De Sario", "given": "Manuela", "initials": "M"}, {"family": "Stortichini", "given": "Matteo", "initials": "M"}, {"family": "Stafoggia", "given": "Massimo", "initials": "M"}, {"family": "Niccioli", "given": "Fiammetta", "initials": "F"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Boros", "given": "Stefano", "initials": "S"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Urdiales", "given": "Alberto Mateo", "initials": "AM"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Rossi", "given": "Pasqualino", "initials": "P"}, {"family": "Rezza", "given": "Giovanni", "initials": "G"}, {"family": "Costa", "given": "Giuseppe", "initials": "G"}, {"family": "Davoli", "given": "Marina", "initials": "M"}], "type": "journal article", "published": "2021-01-09", "journal": {"title": "Epidemiol Prev", "issn": "1120-9763", "issn-l": null, "volume": "44", "issue": "5-6 Suppl 2", "pages": "236-243"}, "abstract": "to assess the temporal variation in excess total mortality and the portion of excess explained by COVID-19 deaths by geographical area, gender, and age during the COVID-19 epidemic.\r\n\r\ndescriptive analysis of temporal variations of total excess deaths and COVID-19 deaths in the phase 1 and phase 2 of the epidemic in Italy.\r\n\r\n12 Northern cities and 20 Central-Southern cities from December 2019 to June 2020: daily mortality from the National Surveillance System of Daily Mortality (SiSMG) and COVID-19 deaths from the integrated COVID-19 surveillance system.\r\n\r\ntotal mortality excess and COVID-19 deaths, defined as deaths in microbiologically confirmed cases of SARS-CoV-2, by gender and age groups.\r\n\r\nthe largest excess mortality was observed in the North and during the first phase of the epidemic. The portion of excess mortality explained by COVID-19 decreases with age, decreasing to 51% among the very old (>=85 years). In phase 2 (until June 2020), the impact was more contained and totally attributable to COVID-19 deaths and this suggests an effectiveness of social distancing measures.\r\n\r\nmortality surveillance is a sensible information basis for the monitoring of health impact of the different phases of the epidemic and supporting decision making at the local and national level on containment measures to put in place in coming months.", "doi": "10.19191/EP20.5-6.S2.123", "pmid": "33412815", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "5208"}], "notes": [], "created": "2021-01-22T09:21:41.132Z", "modified": "2021-02-26T08:47:00.183Z"}, {"entity": "publication", "iuid": "67723ab246aa40aeb3fb9fa0f012aa56", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/67723ab246aa40aeb3fb9fa0f012aa56.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/67723ab246aa40aeb3fb9fa0f012aa56"}}, "title": "[Integrated Surveillance in Italy: outputs and related activities].", "authors": [{"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Urdiales", "given": "Alberto Mateo", "initials": "AM"}, {"family": "Vescio", "given": "Maria Fenicia", "initials": "MF"}, {"family": "Rota", "given": "Maria Cristina", "initials": "MC"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Boros", "given": "Stefano", "initials": "S"}, {"family": "Bellino", "given": "Stefania", "initials": "S"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Ciervo", "given": "Alessandra", "initials": "A"}, {"family": "Punzo", "given": "Ornella", "initials": "O"}, {"family": "Filia", "given": "Antonietta", "initials": "A"}, {"family": "Tallon", "given": "Marco", "initials": "M"}, {"family": "Di Benedetto", "given": "Corrado", "initials": "C"}, {"family": "Spuri", "given": "Matteo", "initials": "M"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Bella", "given": "Antonella", "initials": "A"}, {"family": "Gruppo Referenti regionali della Sorveglianza Integrata COVID-19", "given": "", "initials": ""}], "type": "journal article", "published": "2021-01-09", "journal": {"title": "Epidemiol Prev", "issn": "1120-9763", "volume": "44", "issue": "5-6 Suppl 2", "pages": "70-80", "issn-l": null}, "abstract": "to describe the integrated surveillance system of COVID-19 in Italy, to illustrate the outputs used to return epidemiological information on the spread of the epidemic to the competent public health bodies and to the Italian population, and to describe how the surveillance data contributes to the ongoing weekly regional monitoring and risk assessment system.\n\nthe COVID-19 integrated surveillance system is the result of a close and continuous collaboration between the Italian National Institute of Health (ISS), the Italian Ministry of Health, and the regional and local health authorities. Through a web platform, it collects individual data of laboratory confirmed cases of SARS-CoV-2 infection and gathers information on their residence, laboratory diagnosis, hospitalisation, clinical status, risk factors, and outcome. Results, for different levels of aggregation and risk categories, are published daily and weekly on the ISS website, and made available to national and regional public health authorities; these results contribute one of the information sources of the regional monitoring and risk assessment system.\n\nthe COVID-19 integrated surveillance system monitors the space-time distribution of cases and their characteristics. Indicators used in the weekly regional monitoring and risk assessment system include process indicators on completeness and results indicators on weekly trends of newly diagnosed cases per Region.\n\nthe outputs of the integrated surveillance system for COVID-19 provide timely information to health authorities and to the general population on the evolution of the epidemic in Italy. They also contribute to the continuous re-assessment of risk related to transmission and impact of the epidemic thus contributing to the management of COVID-19 in Italy.", "doi": "10.19191/EP20.5-6.S2.105", "pmid": "33412796", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "5088"}], "notes": [], "created": "2021-01-22T09:22:48.456Z", "modified": "2021-02-26T08:47:00.008Z"}, {"entity": "publication", "iuid": "c8b44880a5bf4cc19fcf261c46c33ab8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c8b44880a5bf4cc19fcf261c46c33ab8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c8b44880a5bf4cc19fcf261c46c33ab8"}}, "title": "Rituximab for the treatment of multiple sclerosis: a review.", "authors": [{"family": "Chisari", "given": "Clara Grazia", "initials": "CG"}, {"family": "Sgarlata", "given": "Eleonora", "initials": "E"}, {"family": "Arena", "given": "Sebastiano", "initials": "S"}, {"family": "Toscano", "given": "Simona", "initials": "S"}, {"family": "Luca", "given": "Maria", "initials": "M"}, {"family": "Patti", "given": "Francesco", "initials": "F"}], "type": "journal article", "published": "2021-01-08", "journal": {"title": "J Neurol", "issn": "1432-1459", "volume": null, "issue": null, "issn-l": null}, "abstract": "In the last decades, evidence suggesting the direct or indirect involvement of B cells on multiple sclerosis (MS) pathogenesis has accumulated. The increased amount of data on the efficacy and safety of B-cell-depleting therapies from several studies has suggested the addition of these drugs as treatment options to the current armamentarium of disease modifying therapies (DMTs) for MS. Particularly, rituximab (RTX), a chimeric monoclonal antibody directed at CD20 positive B lymphocytes resulting in cell-mediated apoptosis, has been demonstrated to reduce inflammatory activity, incidence of relapses and new brain lesions on magnetic resonance imaging (MRI) in patients with relapsing-remitting MS (RRMS). Additional evidence also demonstrated that patients with progressive MS (PMS) may benefit from RTX, which also showed to be well tolerated, with acceptable safety risks and favorable cost-effectiveness profile.Despite these encouraging results, RTX is currently approved for non-Hodgkin's lymphoma, chronic lymphocytic leukemia, several forms of vasculitis and rheumatoid arthritis, while it can only be administered off-label for MS treatment. Between Northern European countries exist different rules for using not licensed drug for treating MS. The Sweden MS register reports a high rate (53.5%) of off-label RTX prescriptions in relation to other annually started DMTs to treat MS patients, while Danish and Norwegian neurologists have to use other anti-CD20 drugs, as ocrelizumab, in most of the cases.In this paper, we review the pharmacokinetics, pharmacodynamics, clinical efficacy, safety profile and cost effectiveness aspects of RTX for the treatment of MS. Particularly, with the approval of new anti-CD20 DMTs, the recent worldwide COVID-19 emergency and the possible increased risk of infection with this class of drugs, this review sheds light on the use of RTX as an alternative treatment option for MS management, while commenting the gaps of knowledge regarding this drug.", "doi": "10.1007/s00415-020-10362-z", "pmid": "33416999", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00415-020-10362-z"}], "notes": [], "created": "2021-01-10T18:21:47.460Z", "modified": "2021-01-10T18:21:47.469Z"}, {"entity": "publication", "iuid": "4977214db52547d5837a73d23539ceee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4977214db52547d5837a73d23539ceee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4977214db52547d5837a73d23539ceee"}}, "title": "Mental Distress and Human Rights Violations During COVID-19: A Rapid Review of the Evidence Informing Rights, Mental Health Needs, and Public Policy Around Vulnerable Populations.", "authors": [{"family": "Rahman", "given": "Muhammad", "initials": "M"}, {"family": "Ahmed", "given": "Rabab", "initials": "R"}, {"family": "Moitra", "given": "Modhurima", "initials": "M"}, {"family": "Damschroder", "given": "Laura", "initials": "L"}, {"family": "Brownson", "given": "Ross", "initials": "R"}, {"family": "Chorpita", "given": "Bruce", "initials": "B"}, {"family": "Idele", "given": "Priscilla", "initials": "P"}, {"family": "Gohar", "given": "Fatima", "initials": "F"}, {"family": "Huang", "given": "Keng Yen", "initials": "KY"}, {"family": "Saxena", "given": "Shekhar", "initials": "S"}, {"family": "Lai", "given": "Joanna", "initials": "J"}, {"family": "Peterson", "given": "Stefan Swartling", "initials": "SS"}, {"family": "Harper", "given": "Gary", "initials": "G"}, {"family": "McKay", "given": "Mary", "initials": "M"}, {"family": "Amugune", "given": "Beatrice", "initials": "B"}, {"family": "Esho", "given": "Tammary", "initials": "T"}, {"family": "Ronen", "given": "Keshet", "initials": "K"}, {"family": "Othieno", "given": "Caleb", "initials": "C"}, {"family": "Kumar", "given": "Manasi", "initials": "M"}], "type": "journal article", "published": "2021-01-08", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "11", "issue": null, "pages": "603875", "issn-l": "1664-0640"}, "abstract": "Background: COVID-19 prevention and mitigation efforts were abrupt and challenging for most countries with the protracted lockdown straining socioeconomic activities. Marginalized groups and individuals are particularly vulnerable to adverse effects of the pandemic such as human rights abuses and violations which can lead to psychological distress. In this review, we focus on mental distress and disturbances that have emanated due to human rights restrictions and violations amidst the pandemic. We underscore how mental health is both directly impacted by the force of pandemic and by prevention and mitigation structures put in place to combat the disease. Methods: We conducted a review of relevant studies examining human rights violations in COVID-19 response, with a focus on vulnerable populations, and its association with mental health and psychological well-being. We searched PubMed and Embase databases for studies between December 2019 to July 2020. Three reviewers evaluated the eligibility criteria and extracted data. Results: Twenty-four studies were included in the systematic inquiry reporting on distress due to human rights violations. Unanimously, the studies found vulnerable populations to be at a high risk for mental distress. Limited mobility rights disproportionately harmed psychiatric patients, low-income individuals, and minorities who were at higher risk for self-harm and worsening mental health. Healthcare workers suffered negative mental health consequences due to stigma and lack of personal protective equipment and stigma. Other vulnerable groups such as the elderly, children, and refugees also experienced negative consequences. Conclusions: This review emphasizes the need to uphold human rights and address long term mental health needs of populations that have suffered disproportionately during the pandemic. Countries can embed a proactive psychosocial response to medical management as well as in existing prevention strategies. International human rights guidelines are useful in this direction but an emphasis should be placed on strengthening rights informed psychosocial response with specific strategies to enhance mental health in the long-term. We underscore that various fundamental human rights are interdependent and therefore undermining one leads to a poor impact on the others. We strongly recommend global efforts toward focusing both on minimizing fatalities, protecting human rights, and promoting long term mental well-being.", "doi": "10.3389/fpsyt.2020.603875", "pmid": "33488426", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7820171"}], "notes": [], "created": "2021-02-04T18:39:24.005Z", "modified": "2021-02-04T18:39:33.273Z"}, {"entity": "publication", "iuid": "c0aa971aae314be58621c5bea009cf62", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c0aa971aae314be58621c5bea009cf62.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c0aa971aae314be58621c5bea009cf62"}}, "title": "Inherent random fluctuations in COVID-19 outbreaks may explain rapid growth of new mutated virus variants", "authors": [{"family": "Bodin", "given": "Kenneth", "initials": "K"}, {"family": "Rocklov", "given": "Joacim", "initials": "J"}], "type": "posted-content", "published": "2021-01-08", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.01.07.21249353", "pmid": null, "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-10T18:36:49.125Z", "modified": "2021-02-26T08:45:48.640Z"}, {"entity": "publication", "iuid": "e3bd61a03fcf42a7871602b18648b374", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3bd61a03fcf42a7871602b18648b374.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3bd61a03fcf42a7871602b18648b374"}}, "title": "Epidemiological characteristics of COVID-19 cases in non-Italian nationals notified to the Italian surveillance system.", "authors": [{"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Bellino", "given": "Stefania", "initials": "S"}, {"family": "Rota", "given": "Maria C", "initials": "MC"}, {"family": "Boros", "given": "Stefano", "initials": "S"}, {"family": "Vescio", "given": "Maria F", "initials": "MF"}, {"family": "D'Ancona", "given": "Fortunato P", "initials": "FP"}, {"family": "Siddu", "given": "Andrea", "initials": "A"}, {"family": "Punzo", "given": "Ornella", "initials": "O"}, {"family": "Filia", "given": "Antonietta", "initials": "A"}, {"family": "Brusaferro", "given": "Silvio", "initials": "S"}, {"family": "Rezza", "given": "Giovanni", "initials": "G"}, {"family": "Dente", "given": "Maria G", "initials": "MG"}, {"family": "Declich", "given": "Silvia", "initials": "S"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "group", "given": "COVID-19 working", "initials": "Cw"}, {"family": ",", "given": "", "initials": ""}], "type": "journal article", "published": "2021-01-08", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": null, "issue": null, "pages": null}, "abstract": "International literature suggests that disadvantaged groups are at higher risk of morbidity and mortality from SARS-CoV-2 infection due to poorer living/working conditions and barriers to healthcare access. Yet, to date, there is no evidence of this disproportionate impact on non-national individuals, including economic migrants, short-term travellers, and refugees.\r\n\r\nWe analysed data from the Italian surveillance system of all COVID-19 laboratory-confirmed cases tested positive from the beginning of the outbreak (20th of February) to the 19th of July 2020. We used multilevel negative-binomial regression models to compare the case-fatality and the rate of admission to hospital and intensive care unit (ICU) between Italian and non-Italian nationals. The analysis was adjusted for differences in demographic characteristics, pre-existing comorbidities, and period of diagnosis.\r\n\r\nWe analysed 213,180 COVID-19 cases, including 15,974 (7.5%) non-Italian nationals. We found that, compared to Italian cases, non-Italian cases were diagnosed at a later date and were more likely to be hospitalised [(adjusted rate ratio (ARR)=1.39, 95% confidence interval (CI): 1.33-1.44)] and admitted to ICU (ARR = 1.19, 95% CI: 1.07-1.32), with differences being more pronounced in those coming from countries with lower HDI. We also observed an increased risk of death in non-Italian cases from low-HDI countries (ARR = 1.32, 95% CI: 1.01-1.75).\r\n\r\nA delayed diagnosis in non-Italian cases could explain their worse outcomes compared to Italian cases. Ensuring early access to diagnosis and treatment to non-Italians could facilitate the control of SARS-CoV-2 transmission and improve health outcomes in all people living in Italy, regardless of nationality.", "doi": "10.1093/eurpub/ckaa249", "pmid": "33416859", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6070147"}], "notes": [], "created": "2021-01-10T18:22:12.486Z", "modified": "2021-06-18T09:27:00.582Z"}, {"entity": "publication", "iuid": "f788045b36924a1fbc1785be50402e62", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f788045b36924a1fbc1785be50402e62.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f788045b36924a1fbc1785be50402e62"}}, "title": "Competing Health Risks Associated with the COVID-19 Pandemic and Response: A Scoping Review", "authors": [{"family": "Baral", "given": "Stefan", "initials": "S"}, {"family": "Rao", "given": "Amrita", "initials": "A"}, {"family": "Twahirwa Rwema", "given": "Jean Olivier", "initials": "JO"}, {"family": "Lyons", "given": "Carrie", "initials": "C"}, {"family": "Cevik", "given": "Muge", "initials": "M"}, {"family": "K\u00e5gesten", "given": "Anna E", "initials": "AE"}, {"family": "Diouf", "given": "Daouda", "initials": "D"}, {"family": "Sohn", "given": "Annette H", "initials": "AH"}, {"family": "Phaswana-Mafuya", "given": "Refilwe", "initials": "R"}, {"family": "Kamarulzaman", "given": "Adeeba", "initials": "A"}, {"family": "Millett", "given": "Gregorio", "initials": "G"}, {"family": "Marcus", "given": "Julia L", "initials": "JL"}, {"family": "Mishra", "given": "Sharmistha", "initials": "S"}], "type": "posted-content", "published": "2021-01-08", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.01.07.21249419", "pmid": null, "labels": {"Type: Review": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-01-29T17:36:34.092Z", "modified": "2021-06-09T19:28:34.774Z"}, {"entity": "publication", "iuid": "02eaf5bdae9e4092b8b24cd7533ece27", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02eaf5bdae9e4092b8b24cd7533ece27.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02eaf5bdae9e4092b8b24cd7533ece27"}}, "title": "COVID-19 epidemic in Libya.", "authors": [{"family": "Bredan", "given": "Amin", "initials": "A"}, {"family": "Bakoush", "given": "Omran", "initials": "O"}], "type": "journal article", "published": "2021-01-08", "journal": {"title": "Libyan J Med", "issn": "1819-6357", "issn-l": null, "volume": "16", "issue": "1", "pages": "1871798"}, "abstract": "The first case of COVID-19 was identified in Libya on 24/3/2020, and about 2 months later, the number of reported COVID-19 cases started to increase notably. The outbreak was first prominent in the southern region (Sabha) and then spread to the western and eastern parts of Libya. By 24/12/2020, the reported total number of deaths from COVID-19 reached 1415. There seems to be no published data on the size of the epidemic in Libya. Here, we estimated the number of Libyans exposed to COVID-19 by using a COVID-19 mortality adjusted mathematical model for the spread of infectious diseases. We estimated that 14-20% of the Libyan population have been exposed to the COVID-19 pandemic. Thus, the risk of spread of COVID-19 infections during the coming months is high, and a considerable number of Libyans, particularly the elderly and people with chronic diseases, should be protected against COVID-19 infection. This is particularly urgent in the light of unofficial reports that the relevant healthcare facilities are under extreme stress.", "doi": "10.1080/19932820.2021.1871798", "pmid": "33407008", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-07T17:09:02.169Z", "modified": "2021-06-18T09:54:28.522Z"}, {"entity": "publication", "iuid": "5ef2c75ecf0643128f220f1ae1ce1bdf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5ef2c75ecf0643128f220f1ae1ce1bdf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5ef2c75ecf0643128f220f1ae1ce1bdf"}}, "title": "Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma", "authors": [{"family": "Kermani", "given": "Nazanin Zounemat", "initials": "NZ"}, {"family": "None", "given": "", "initials": ""}, {"family": "Song", "given": "Woo Jung", "initials": "WJ"}, {"family": "Badi", "given": "Yusef", "initials": "Y"}, {"family": "Versi", "given": "Ali", "initials": "A"}, {"family": "Guo", "given": "Yike", "initials": "Y"}, {"family": "Sun", "given": "Kai", "initials": "K"}, {"family": "Bhavsar", "given": "Pank", "initials": "P"}, {"family": "Howarth", "given": "Peter", "initials": "P"}, {"family": "Dahlen", "given": "Sven Erik", "initials": "SE"}, {"family": "Sterk", "given": "Peter J", "initials": "PJ"}, {"family": "Djukanovic", "given": "Ratko", "initials": "R"}, {"family": "Adcock", "given": "Ian M", "initials": "IM"}, {"family": "Chung", "given": "Kian Fan", "initials": "KF"}], "type": "journal-article", "published": "2021-01-07", "journal": {"title": "Respir Res", "issn": "1465-993X", "issn-l": "1465-9921", "volume": "22", "issue": "1", "pages": "101876"}, "abstract": "Bats are reservoirs for a large number of viruses which have potential to cause major human disease outbreaks, including the current coronavirus disease 2019 (COVID-19) pandemic. Major efforts are underway to understand bat immune response to viruses, whereas much less is known about their immune responses to bacteria. In this study, MR1-restricted T (MR1T) cells were detected through the use of MR1 tetramers in circulation and tissues of Pteropus alecto (Pa) bats. Pa MR1T cells exhibited weak responses to MR1-presented microbial metabolites at resting state. However, following priming with MR1-presented agonist they proliferated, upregulated critical transcription factors and cytolytic proteins, and gained transient expression of Th1/17-related cytokines and antibacterial cytotoxicity. Collectively, these findings show that the Pa bat immune system encompasses an abundant and functionally conserved population of MR1T cells with mucosal-associated invariant T-like characteristics, suggesting that MR1 and MR1T cells also play a significant role in bat immune defense.", "doi": "10.1186/s12931-020-01605-8", "pmid": "33344919", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-10T18:25:02.052Z", "modified": "2021-02-26T08:45:48.250Z"}, {"entity": "publication", "iuid": "fd17970ab9a34ca4a39b8a169f6a9f15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fd17970ab9a34ca4a39b8a169f6a9f15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fd17970ab9a34ca4a39b8a169f6a9f15"}}, "title": "Parental experiences of homeschooling during the COVID-19 pandemic: differences between seven European countries and between children with and without mental health conditions", "authors": [{"family": "Thorell", "given": "Lisa B", "initials": "LB"}, {"family": "Skoglund", "given": "Charlotte", "initials": "C"}, {"family": "de la Pe\u00f1a", "given": "Almudena Gim\u00e9nez", "initials": "AG"}, {"family": "Baeyens", "given": "Dieter", "initials": "D"}, {"family": "Fuermaier", "given": "Anselm B M", "initials": "ABM"}, {"family": "Groom", "given": "Madeleine J", "initials": "MJ"}, {"family": "Mammarella", "given": "Irene C", "initials": "IC"}, {"family": "van der Oord", "given": "Saskia", "initials": "S"}, {"family": "van den Hoofdakker", "given": "Barbara J", "initials": "BJ"}, {"family": "Luman", "given": "Marjolein", "initials": "M"}, {"family": "de Miranda", "given": "D\u00e9bora Marques", "initials": "DM"}, {"family": "Siu", "given": "Angela F Y", "initials": "AFY"}, {"family": "Steinmayr", "given": "Ricarda", "initials": "R"}, {"family": "Idrees", "given": "Iman", "initials": "I"}, {"family": "Soares", "given": "Lorrayne Stephane", "initials": "LS"}, {"family": "S\u00f6rlin", "given": "Matilda", "initials": "M"}, {"family": "Luque", "given": "Juan Luis", "initials": "JL"}, {"family": "Moscardino", "given": "Ughetta M", "initials": "UM"}, {"family": "Roch", "given": "Maja", "initials": "M"}, {"family": "Crisci", "given": "Giulia", "initials": "G"}, {"family": "Christiansen", "given": "Hanna", "initials": "H"}], "type": "journal-article", "published": "2021-01-07", "journal": {"title": "Eur Child Adolesc Psychiatry", "issn": "1018-8827", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1007/s00787-020-01706-1", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-10T18:23:30.328Z", "modified": "2021-06-18T09:16:00.365Z"}, {"entity": "publication", "iuid": "d6033efeda044768b62aab15cc8406a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d6033efeda044768b62aab15cc8406a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d6033efeda044768b62aab15cc8406a0"}}, "title": "Minimal transmission of SARS-CoV-2 from paediatric COVID-19 cases in primary schools, Norway, August to November 2020", "authors": [{"family": "Brandal", "given": "Lin T", "initials": "LT"}, {"family": "Ofitserova", "given": "Trine S", "initials": "TS"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}, {"family": "Rykkvin", "given": "Rikard", "initials": "R"}, {"family": "Lund", "given": "Hilde M", "initials": "HM"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "Greve-Isdahl", "given": "Margrethe", "initials": "M"}, {"family": "Bragstad", "given": "Karoline", "initials": "K"}, {"family": "Nyg\u00e5rd", "given": "Karin", "initials": "K"}, {"family": "Winje", "given": "Brita A", "initials": "BA"}], "type": "journal-article", "published": "2021-01-07", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "1", "pages": null}, "abstract": null, "doi": "10.2807/1560-7917.es.2020.26.1.2002011", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "NA", "key": "Available in paper; Detection of SARS-CoV-2 in saliva samples from paediatric COVID-19 index cases and their school contacts", "description": null}], "notes": [], "created": "2021-01-10T18:24:13.864Z", "modified": "2021-06-18T09:43:42.157Z"}, {"entity": "publication", "iuid": "517a97de636c40abaceadf785b375e76", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/517a97de636c40abaceadf785b375e76.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/517a97de636c40abaceadf785b375e76"}}, "title": "Covid-19 FAQ's in Paediatric and Congenital Cardiology - AEPC position paper.", "authors": [{"family": "Sendzikaite", "given": "Skaiste", "initials": "S"}, {"family": "Heying", "given": "Ruth", "initials": "R"}, {"family": "Milanesi", "given": "Ornella", "initials": "O"}, {"family": "Hanseus", "given": "Katarina", "initials": "K"}, {"family": "Michel-Behnke", "given": "Ina", "initials": "I"}], "type": "journal article", "published": "2021-01-07", "journal": {"title": "Cardiol Young", "issn": "1467-1107", "volume": null, "issue": null, "pages": "1-21", "issn-l": null}, "abstract": "The Covid-19 pandemic has had a huge influence in almost all areas of life, affecting societies, economics and health care systems worldwide. The paediatric cardiology community is no exception. As the challenging battle with Covid-19 continues, professionals from the Association for the European Paediatric and Congenital Cardiology (AEPC) receive many questions regarding Covid-19 in a Paediatric and Congenital Cardiology setting. The aim of this paper is to present the AEPC position on frequently asked questions based on the most recent scientific data, as well as to frame a discussion on how to take care of our patients during this unprecedented crisis. As the times are changing quickly and information regarding Covid-19 is very dynamic, continuous collection of evidence will help guide constructive decision-making.", "doi": "10.1017/S1047951120005028", "pmid": "33407975", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1047951120005028"}], "notes": [], "created": "2021-01-07T17:07:20.941Z", "modified": "2021-01-10T18:28:15.315Z"}, {"entity": "publication", "iuid": "c7e1e3e4c7c44e44bc461e8198ec1610", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7e1e3e4c7c44e44bc461e8198ec1610.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7e1e3e4c7c44e44bc461e8198ec1610"}}, "title": "Prehospital identification of Covid-19: an observational study.", "authors": [{"family": "Spangler", "given": "Douglas", "initials": "D"}, {"family": "Blomberg", "given": "Hans", "initials": "H"}, {"family": "Smekal", "given": "David", "initials": "D"}], "type": "journal article", "published": "2021-01-06", "journal": {"title": "Scand J Trauma Resusc Emerg Med", "issn": "1757-7241", "volume": "29", "issue": "1", "pages": "3", "issn-l": "1757-7241"}, "abstract": "The novel coronavirus disease 2019 (Covid-19) pandemic has affected prehospital care systems across the world, but the prehospital presentation of affected patients and the extent to which prehospital care providers are able to identify them is not well characterized. In this study, we describe the presentation of Covid-19 patients in a Swedish prehospital care system, and asses the predictive value of Covid-19 suspicion as documented by dispatch and ambulance nurses.\n\nData for all patients with dispatch, ambulance, and hospital records between January 1-August 31, 2020 were extracted. A descriptive statistical analysis of patients with and without hospital-confirmed Covid-19 was performed. In a subset of records beginning from April 14, we assessed the sensitivity and specificity of documented Covid-19 suspicion in dispatch and ambulance patient care records.\n\nA total of 11,894 prehospital records were included, of which 481 had a primary hospital diagnosis code related to-, or positive test results for Covid-19. Covid-19-positive patients had considerably worse outcomes than patients with negative test results, with 30-day mortality rates of 24% vs 11%, but lower levels of prehospital acuity (e.g. emergent transport rates of 14% vs 22%). About half (46%) of Covid-19-positive patients presented to dispatchers with primary complaints typically associated with Covid-19. Six thousand seven hundred seventy-six records were included in the assessment of predictive value. Sensitivity was 76% (95% CI 71-80) and 82% (78-86) for dispatch and ambulance suspicion respectively, while specificities were 86% (85-87) and 78% (77-79).\n\nWhile prehospital suspicion was strongly indicative of hospital-confirmed Covid-19, based on the sensitivity identified in this study, prehospital suspicion should not be relied upon as a single factor to rule out the need for isolation precautions. The data provided may be used to develop improved guidelines for identifying Covid-19 patients in the prehospital setting.", "doi": "10.1186/s13049-020-00826-6", "pmid": "33407750", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-07T17:08:24.708Z", "modified": "2021-02-26T08:45:48.690Z"}, {"entity": "publication", "iuid": "9743266e3b1c4018b98b4ba412d671cd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9743266e3b1c4018b98b4ba412d671cd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9743266e3b1c4018b98b4ba412d671cd"}}, "title": "Biosocial Strategies to Address the Socioeconomic Determinants and Consequences of the TB and COVID-19 Pandemics.", "authors": [{"family": "Pedrazzoli", "given": "Debora", "initials": "D"}, {"family": "Wingfield", "given": "Tom", "initials": "T"}], "type": "journal article", "published": "2021-01-06", "journal": {"title": "Am J Trop Med Hyg", "issn": "1476-1645", "issn-l": "0002-9637", "volume": null, "issue": null, "pages": null}, "abstract": "Biosocial Strategies to Address the Socioeconomic Determinants and Consequences of the TB and COVID-19 Syndemics.", "doi": "10.4269/ajtmh.20-1641", "pmid": "33410391", "labels": {"Type: Other": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-08T07:18:14.824Z", "modified": "2021-06-18T09:11:25.810Z"}, {"entity": "publication", "iuid": "7d7c1595811b45f09fec445a255d13db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d7c1595811b45f09fec445a255d13db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d7c1595811b45f09fec445a255d13db"}}, "title": "The challenges of COVID-19 testing in Africa: the Ethiopian experience.", "authors": [{"family": "Mulu", "given": "Andargachew", "initials": "A"}, {"family": "Bekele", "given": "Amsalu", "initials": "A"}, {"family": "Abdissa", "given": "Alemseged", "initials": "A"}, {"family": "Balcha", "given": "Taye Tolera", "initials": "TT"}, {"family": "Habtamu", "given": "Meseret", "initials": "M"}, {"family": "Mihret", "given": "Adane", "initials": "A"}, {"family": "Alemayehu", "given": "Dawit Hailu", "initials": "DH"}, {"family": "Beyene", "given": "Getachew Tesfaye", "initials": "GT"}, {"family": "Bayih", "given": "Abebe Genetu", "initials": "AG"}], "type": "journal article", "published": "2021-01-05", "journal": {"title": "Pan Afr Med J", "issn": "1937-8688", "issn-l": null, "volume": "38", "issue": null, "pages": "6"}, "abstract": "Novel coronavirus disease (COVID-19) is spreading rapidly and creating a huge economic, social and public health challenge worldwide. Although currently an effective vaccine is ready, its distribution is limited, and hence the only currently available lever to reduce transmission is to identify and isolate individuals who are contagious. Thus, testing for SARS CoV-2 has a paramount importance. However, testing in many African countries including Ethiopia has multidimensional growing challenges. Here, we tried to identify, categorize and summarize the challenges of COVID-19 testing in Africa from Ethiopian experience.", "doi": "10.11604/pamj.2021.38.6.26902", "pmid": "33520075", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PAMJ-38-6"}, {"db": "pmc", "key": "PMC7825374"}], "notes": [], "created": "2021-02-04T18:37:05.674Z", "modified": "2021-06-18T08:50:19.957Z"}, {"entity": "publication", "iuid": "7de895fcacdf46a48f1977a21c2c05d1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7de895fcacdf46a48f1977a21c2c05d1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7de895fcacdf46a48f1977a21c2c05d1"}}, "title": "Recovery scenario and immunity in COVID-19 disease: A new strategy to predict the potential of reinfection.", "authors": [{"family": "Khoshkam", "given": "Zahra", "initials": "Z"}, {"family": "Aftabi", "given": "Younes", "initials": "Y"}, {"family": "Stenvinkel", "given": "Peter", "initials": "P"}, {"family": "Paige Lawrence", "given": "B", "initials": "B"}, {"family": "Rezaei", "given": "Mehran Habibi", "initials": "MH"}, {"family": "Ichihara", "given": "Gaku", "initials": "G"}, {"family": "Fereidouni", "given": "Sasan", "initials": "S"}], "type": "journal article", "published": "2021-01-05", "journal": {"title": "J Adv Res", "issn": "2090-1232", "volume": null, "issue": null, "issn-l": null}, "abstract": "The recent ongoing outbreak of coronavirus disease 2019 (COVID-19), still is an unsolved problem with a growing rate of infected cases and mortality worldwide. The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is targeting the angiotensin-converting enzyme 2 (ACE2) receptor and mostly causes a respiratory illness. Although acquired and resistance immunity is one of the most important aspects of alleviating the trend of the current pandemic; however, there is still a big gap of knowledge regarding the infection process, immunopathogenesis, recovery, and reinfection.\n\nTo answer the questions regarding \"the potential and probability of reinfection in COVID-19 infected cases\" or \"the efficiency and duration of SARS-CoV-2 infection-induced immunity against reinfection\" we critically evaluated the current reports on SARS-CoV-2 immunity and reinfection with special emphasis on comparative studies using animal models that generalize their finding about protection and reinfection. Also, the contribution of humoral immunity in the process of COVID-19 recovery and the role of ACE2 in virus infectivity and pathogenesis has been discussed. Furthermore, innate and cellular immunity and inflammatory responses in the disease and recovery conditions are reviewed and an overall outline of immunologic aspects of COVID-19 progression and recovery in three different stages are presented. Finally, we categorized the infected cases into four different groups based on the acquired immunity and the potential for reinfection.\n\nIn this review paper, we proposed a new strategy to predict the potential of reinfection in each identified category. This classification may help to distribute resources more meticulously to determine: who needs to be serologically tested for SARS-CoV-2 neutralizing antibodies, what percentage of the population is immune to the virus, and who needs to be vaccinated.", "doi": "10.1016/j.jare.2020.12.013", "pmid": "33520309", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2090-1232(20)30263-0"}, {"db": "pmc", "key": "PMC7832464"}], "notes": [], "created": "2021-02-04T18:31:22.502Z", "modified": "2021-02-04T18:31:53.526Z"}, {"entity": "publication", "iuid": "3dd3f252fe0c478dab38a085893b9814", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3dd3f252fe0c478dab38a085893b9814.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3dd3f252fe0c478dab38a085893b9814"}}, "title": "COVID-19 and seafarers' rights to shore leave, repatriation and medical assistance: a pilot study.", "authors": [{"family": "Hebbar", "given": "Anish Arvind", "initials": "AA"}, {"family": "Mukesh", "given": "Nitin", "initials": "N"}], "type": "journal article", "published": "2021-01-05", "journal": {"title": "Int Marit Health", "issn": "2081-3252", "issn-l": null, "volume": "71", "issue": "4", "pages": "217-228"}, "abstract": "The well-being of the world's 1.65 million seafarers is expected to be secured by the rights established under the Maritime Labour Convention (MLC), 2006 with active monitoring of its implementation by the flag administrations through the International Maritime Organisation (IMO) and International Labour Organisation (ILO). However, the substantial gains achieved since entry into force of MLC in August 2013 appear to have been severely dented by the COVID-19 global pandemic. The aim of the study was to examine, on a pilot basis, the disruptions and challenges to the observance of seafarers' rights to shore leave, repatriation and medical assistance as an immediate consequence of COVID-19.\r\n\r\nThe impact of COVID-19 on seafarers' rights was examined in three dimensions - shore leave, repatriation and medical assistance. Questionnaires were administered online from June to August 2020 to 450 seafarers, top 10 ship-management companies, 35 shipping companies and maritime administrations of top 5 seafarer supplying countries. The paper discusses the results of the survey.\r\n\r\nThe research revealed a previously unknown majority preference for shore leave, that diminished sharply during COVID-19. Impact on work-performance and well-being of seafarers was revealed with only a fifth of the seafarers having willingly agreed to an extension of contract. This study revealed incidence rates at 6 months into the pandemic of several parameters - delayed repatriations (21.44%) that includes crew with contract extensions (12.48%), crew with completed contract awaiting repatriation (8.96%) and crew that had exceeded 12-month continuous service (0.82%). Compensation, if provided, is meagre and was affecting ratings the most. Deprivation of medical assistance was also revealed.\r\n\r\nThe well being of seafarers would likely remain vulnerable to breaches, unless measures are put in place to safeguard the rights assured under MLC in the face of uncertainties caused by a pandemic such as COVID-19.", "doi": "10.5603/IMH.2020.0040", "pmid": "33394486", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "VM/OJS/J/72010"}], "notes": [], "created": "2021-01-05T15:23:14.849Z", "modified": "2021-06-18T09:44:21.762Z"}, {"entity": "publication", "iuid": "01e5014ff5dc46a1a5e0b0b849134ab7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01e5014ff5dc46a1a5e0b0b849134ab7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01e5014ff5dc46a1a5e0b0b849134ab7"}}, "title": "The Swedish COVID-19 intensive care cohort: Risk of ICU admission and ICU mortality.", "authors": [{"family": "Ahlstr\u00f6m", "given": "B", "initials": "B"}, {"family": "Frithiof", "given": "R", "initials": "R"}, {"family": "Hultstr\u00f6m", "given": "M", "initials": "M"}, {"family": "Larsson", "given": "I-M", "initials": "I"}, {"family": "Strandberg", "given": "G", "initials": "G"}, {"family": "Lipcsey", "given": "M", "initials": "M"}], "type": "journal-article", "published": "2021-01-04", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "0001-5172", "issn-l": null, "volume": "65", "issue": "4", "pages": "525-533"}, "abstract": "Abstract\r\nBackground: Several studies have recently addressed factors associated with severe Coronavirus disease 2019 (COVID-19); however, some medications and comorbidities have yet to be evaluated in a large matched cohort. We therefore explored the role of relevant comorbidities and medications in relation to the risk of intensive care unit (ICU) admission and mortality.\r\n\r\nMethods: All ICU COVID-19 patients in Sweden until 27 May 2020 were matched to population controls on age and sex to assess the risk of ICU admission. Cases were identified, comorbidities and medications were retrieved from high-quality registries. Three conditional logistic regression models were used for risk of ICU admission and three Cox proportional hazards models for risk of ICU mortality, one with comorbidities, one with medications and finally with both models combined, respectively.\r\n\r\nResults: We included 1981 patients and 7924 controls. Hypertension, type 2 diabetes mellitus, chronic renal failure, asthma, obesity, being a solid organ transplant recipient and immunosuppressant medications were independent risk factors of ICU admission and oral anticoagulants were protective. Stroke, asthma, chronic obstructive pulmonary disease and treatment with renin-angiotensin-aldosterone inhibitors (RAASi) were independent risk factors of ICU mortality in the pre-specified primary analyses; treatment with statins was protective. However, after adjusting for the use of continuous renal replacement therapy, RAASi were no longer an independent risk factor.\r\n\r\nConclusion: In our cohort oral anticoagulants were protective of ICU admission and statins was protective of ICU death. Several comorbidities and ongoing RAASi treatment were independent risk factors of ICU admission and ICU mortality.\r\n\r\nThis article is protected by", "doi": "10.1111/aas.13781", "pmid": "33438198", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-04T09:13:48.635Z", "modified": "2022-02-14T15:44:21.282Z"}, {"entity": "publication", "iuid": "fd2d575684ab488480008cfc0b6bae18", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fd2d575684ab488480008cfc0b6bae18.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fd2d575684ab488480008cfc0b6bae18"}}, "title": "SARS-CoV-2 encephalitis is a cytokine release syndrome: evidences from cerebrospinal fluid analyses", "authors": [{"family": "Pilotto", "given": "Andrea", "initials": "A"}, {"family": "Masciocchi", "given": "Stefano", "initials": "S"}, {"family": "Volonghi", "given": "Irene", "initials": "I"}, {"family": "De Giuli", "given": "Valeria", "initials": "V"}, {"family": "Caprioli", "given": "Francesca", "initials": "F"}, {"family": "Mariotto", "given": "Sara", "initials": "S"}, {"family": "Ferrari", "given": "Sergio", "initials": "S"}, {"family": "Bozzetti", "given": "Silvia", "initials": "S"}, {"family": "Imarisio", "given": "Alberto", "initials": "A"}, {"family": "Risi", "given": "Barbara", "initials": "B"}, {"family": "Premi", "given": "Enrico", "initials": "E"}, {"family": "Benussi", "given": "Alberto", "initials": "A"}, {"family": "Foc\u00e0", "given": "Emanuele", "initials": "E"}, {"family": "Castelli", "given": "Francesco", "initials": "F"}, {"family": "Zanusso", "given": "Gianluigi", "initials": "G"}, {"family": "Monaco", "given": "Salvatore", "initials": "S"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Gasparotti", "given": "Roberto", "initials": "R"}, {"family": "Zekeridou", "given": "Anastasia", "initials": "A"}, {"family": "McKeon", "given": "Andrew", "initials": "A"}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ"}, {"family": "Blennov", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Padovani", "given": "Alessandro", "initials": "A"}], "type": "journal-article", "published": "2021-01-04", "journal": {"title": "Clin Infect Dis", "issn": "1058-4838", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1093/cid/ciaa1933", "pmid": null, "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available in paper: Clinical features, imaging and CSF biochemical analyses of SARS-CoV-2 encephalitis cases", "description": null}, {"db": "NA", "key": "Available in paper: Clinical features, imaging and CSF biochemical analyses of COV-Enc cases", "description": null}], "notes": [], "created": "2021-01-05T15:20:43.277Z", "modified": "2021-06-18T10:02:34.967Z"}, {"entity": "publication", "iuid": "07ae93d4452b4555a315d7225e13863b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07ae93d4452b4555a315d7225e13863b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07ae93d4452b4555a315d7225e13863b"}}, "title": "Public Mobility and Social Media Attention in Response to COVID-19 in Sweden and Denmark.", "authors": [{"family": "Zhang", "given": "Le", "initials": "L"}, {"family": "Brikell", "given": "Isabell", "initials": "I"}, {"family": "Dalsgaard", "given": "S\u00f8ren", "initials": "S"}, {"family": "Chang", "given": "Zheng", "initials": "Z"}], "type": "journal article", "published": "2021-01-04", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "volume": "4", "issue": "1", "pages": "e2033478", "issn-l": null}, "abstract": null, "doi": "10.1001/jamanetworkopen.2020.33478", "pmid": "33394001", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "2774527"}], "notes": [], "created": "2021-01-07T10:04:55.103Z", "modified": "2021-02-26T08:46:59.814Z"}, {"entity": "publication", "iuid": "ddf4db5c2836473c816d391d7b547eb9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ddf4db5c2836473c816d391d7b547eb9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ddf4db5c2836473c816d391d7b547eb9"}}, "title": "More research is needed on the long-term effects of COVID-19 on children and adolescents.", "authors": [{"family": "Hertting", "given": "Olof", "initials": "O"}], "type": "editorial", "published": "2021-01-04", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": null, "issue": null, "pages": null}, "abstract": "Editorial", "doi": "10.1111/apa.15731", "pmid": "33395729", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-07T10:00:23.633Z", "modified": "2021-01-07T10:00:46.227Z"}, {"entity": "publication", "iuid": "52f8c81d169e44dfa9c5a9e9ee5622a8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/52f8c81d169e44dfa9c5a9e9ee5622a8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/52f8c81d169e44dfa9c5a9e9ee5622a8"}}, "title": "Little evidence for facemask use in children against COVID-19.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "editorial", "published": "2021-01-03", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": null, "issue": null, "pages": null}, "abstract": "Editorial", "doi": "10.1111/apa.15729", "pmid": "33393117", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-07T09:56:13.495Z", "modified": "2021-01-07T09:56:56.673Z"}, {"entity": "publication", "iuid": "6d40a9ed6d164a33a7968a3d377566db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6d40a9ed6d164a33a7968a3d377566db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6d40a9ed6d164a33a7968a3d377566db"}}, "title": "Treatment of severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19): a systematic review of in vitro, in vivo, and clinical trials.", "authors": [{"family": "Han", "given": "Young Joo", "initials": "YJ"}, {"family": "Lee", "given": "Keum Hwa", "initials": "KH"}, {"family": "Yoon", "given": "Sojung", "initials": "S"}, {"family": "Nam", "given": "Seoung Wan", "initials": "SW"}, {"family": "Ryu", "given": "Seohyun", "initials": "S"}, {"family": "Seong", "given": "Dawon", "initials": "D"}, {"family": "Kim", "given": "Jae Seok", "initials": "JS"}, {"family": "Lee", "given": "Jun Young", "initials": "JY"}, {"family": "Yang", "given": "Jae Won", "initials": "JW"}, {"family": "Lee", "given": "Jinhee", "initials": "J"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Hong", "given": "Sung Hwi", "initials": "SH"}, {"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Smith", "given": "Lee", "initials": "L"}, {"family": "Oh", "given": "Hans", "initials": "H"}, {"family": "Ghayda", "given": "Ramy Abou", "initials": "RA"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Effenberger", "given": "Maria", "initials": "M"}, {"family": "Kresse", "given": "Daniela", "initials": "D"}, {"family": "Denicol\u00f2", "given": "Sara", "initials": "S"}, {"family": "Kang", "given": "Woosun", "initials": "W"}, {"family": "Jacob", "given": "Louis", "initials": "L"}, {"family": "Shin", "given": "Hanwul", "initials": "H"}, {"family": "Shin", "given": "Jae Il", "initials": "JI"}], "type": "journal article", "published": "2021-01-01", "journal": {"title": "Theranostics", "issn": "1838-7640", "volume": "11", "issue": "3", "pages": "1207-1231", "issn-l": null}, "abstract": "Rationale: Coronavirus disease 2019 (COVID-19) has spread worldwide and poses a threat to humanity. However, no specific therapy has been established for this disease yet. We conducted a systematic review to highlight therapeutic agents that might be effective in treating COVID-19. Methods: We searched Medline, Medrxiv.org, and reference lists of relevant publications to identify articles of in vitro, in vivo, and clinical studies on treatments for severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and COVID-19 published in English until the last update on October 11, 2020. Results: We included 36 studies on SARS, 30 studies on MERS, and 10 meta-analyses on SARS and MERS in this study. Through 12,200 title and 830 full-text screenings for COVID-19, eight in vitro studies, 46 randomized controlled trials (RCTs) on 6,886 patients, and 29 meta-analyses were obtained and investigated. There was no therapeutic agent that consistently resulted in positive outcomes across SARS, MERS, and COVID-19. Remdesivir showed a therapeutic effect for COVID-19 in two RCTs involving the largest number of total participants (n = 1,461). Other therapies that showed an effect in at least two RCTs for COVID-19 were sofosbuvir/daclatasvir (n = 114), colchicine (n = 140), IFN-\u03b21b (n = 193), and convalescent plasma therapy (n = 126). Conclusions: This review provides information to help establish treatment and research directions for COVID-19 based on currently available evidence. Further RCTs are required.", "doi": "10.7150/thno.48342", "pmid": "33391531", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "thnov11p1207"}, {"db": "pmc", "key": "PMC7738873"}], "notes": [], "created": "2021-01-07T11:19:21.921Z", "modified": "2021-01-07T11:19:21.947Z"}, {"entity": "publication", "iuid": "53ae2386675c4a4ba33a03cf8ce33fb7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53ae2386675c4a4ba33a03cf8ce33fb7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53ae2386675c4a4ba33a03cf8ce33fb7"}}, "title": "The ABCs of Covid-19 prevention in Malawi: Authority, benefits, and costs of compliance.", "authors": [{"family": "Kao", "given": "Kristen", "initials": "K"}, {"family": "Lust", "given": "Ellen", "initials": "E"}, {"family": "Dulani", "given": "Boniface", "initials": "B"}, {"family": "Ferree", "given": "Karen E", "initials": "KE"}, {"family": "Harris", "given": "Adam S", "initials": "AS"}, {"family": "Metheney", "given": "Erica", "initials": "E"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "World Dev", "issn": "0305-750X", "volume": "137", "issue": null, "pages": "105167", "issn-l": null}, "abstract": "A wide array of authorities-from religious leaders to government ministers-call upon citizens to take preventative measures against Covid-19. Which authorities can most effectively gain public compliance, and which measures will the public take up? Moreover, do people comply with authorities out of respect for their legitimacy, due to their expertise, or for fear of sanctioning? Answers to these questions are important for development practitioners, who need to understand how different partnerships might affect health behavior, and for scholars interested in understanding authority, legitimacy, and compliance. We explore these questions using a conjoint experiment embedded in a telephone survey of 641 Malawians. Individuals in our sample are more likely to say that they will comply with precautionary measures when the costs are low and expected benefits are high. Respondents view both traditional authorities and hospital heads as legitimately issuing directives and having the ability to monitor and sanction non-compliance, but appear to comply more with hospital heads and to do so out of respect for their expertise. These results emphasize how who issues directives affects whether individuals comply and provides insights as to why they do so. The findings also reflect individuals' cost-benefit calculations when considering precautionary measures, highlighting the importance of steps that can reduce costs (e.g., food security or income measures) or accurately reflect risks (e.g., information signaling the prevalence of Covid-19). The study not only helps to address the Coronavirus crisis but also has important implications for broader questions of authority and compliance.", "doi": "10.1016/j.worlddev.2020.105167", "pmid": "32904501", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0305-750X(20)30294-1"}, {"db": "pii", "key": "105167"}, {"db": "pmc", "key": "PMC7455236"}], "notes": [], "created": "2020-12-03T16:14:55.886Z", "modified": "2020-12-03T16:14:55.900Z"}, {"entity": "publication", "iuid": "d12ec989605142b5bc38043f089487db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d12ec989605142b5bc38043f089487db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d12ec989605142b5bc38043f089487db"}}, "title": "Temporal increase in D614G mutation of SARS-CoV-2 in the Middle East and North Africa.", "authors": [{"family": "Sallam", "given": "Malik", "initials": "M"}, {"family": "Ababneh", "given": "Nidaa A", "initials": "NA"}, {"family": "Dababseh", "given": "Deema", "initials": "D"}, {"family": "Bakri", "given": "Faris G", "initials": "FG"}, {"family": "Mahafzah", "given": "Azmi", "initials": "A"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": "7", "issue": "1", "pages": "e06035", "issn-l": null}, "abstract": "Phylogeny construction can help to reveal evolutionary relatedness among molecular sequences. The spike ( S) gene of SARS-CoV-2 is the subject of an immune selective pressure which increases the variability in such region. This study aimed to identify mutations in the S gene among SARS-CoV-2 sequences collected in the Middle East and North Africa (MENA), focusing on the D614G mutation, that has a presumed fitness advantage. Another aim was to analyze the S gene sequences phylogenetically.\n\nThe SARS-CoV-2 S gene sequences collected in the MENA were retrieved from the GISAID public database, together with its metadata. Mutation analysis was conducted in Molecular Evolutionary Genetics Analysis software. Phylogenetic analysis was done using maximum likelihood (ML) and Bayesian methods.\n\nA total of 553 MENA sequences were analyzed and the most frequent S gene mutations included: D614G = 435, Q677H = 8, and V6F = 5. A significant increase in the proportion of D614G was noticed from (63.0%) in February 2020, to (98.5%) in June 2020 (p < 0.001). Two large phylogenetic clusters were identified via ML analysis, which showed an evidence of inter-country mixing of sequences, which dated back to February 8, 2020 and March 15, 2020 (median estimates). The mean evolutionary rate for SARS-CoV-2 was about 6.5 \u00d7 10-3 substitutions/site/year based on large clusters' Bayesian analyses.\n\nThe D614G mutation appeared to be taking over the COVID-19 infections in the MENA. Bayesian analysis suggested that SARS-CoV-2 might have been circulating in MENA earlier than previously reported.", "doi": "10.1016/j.heliyon.2021.e06035", "pmid": "33495741", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)00140-7"}, {"db": "pmc", "key": "PMC7817394"}], "notes": [], "created": "2021-01-29T15:21:33.803Z", "modified": "2021-02-26T08:45:14.457Z"}, {"entity": "publication", "iuid": "b45d9aadb46742d991a0e44c8f1c65b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b45d9aadb46742d991a0e44c8f1c65b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b45d9aadb46742d991a0e44c8f1c65b4"}}, "title": "Sex differences in COVID-19: the role of androgens in disease severity and progression.", "authors": [{"family": "Mohamed", "given": "Mohamed S", "initials": "MS"}, {"family": "Moulin", "given": "Thiago C", "initials": "TC", "orcid": "0000-0001-7811-5383", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5480e69e1fd4d3cb11c758c637ab663.json"}}, {"family": "Schi\u00f6th", "given": "Helgi B", "initials": "HB"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Endocrine", "issn": "1559-0100", "issn-l": "1355-008X", "volume": "71", "issue": "1", "pages": "3-8"}, "abstract": "Throughout the SARS-CoV2 pandemic, multiple reports show higher percentages of hospitalization, morbidity, and mortality among men than women, indicating that men are more affected by COVID-19. The pathophysiology of this difference is yet not established, but recent studies suggest that sex hormones may influence the viral infectivity process. Here, we review the current evidence of androgen sensitivity as a decisive factor for COVID-19 disease severity.\n\nRelevant literature investigating the role of androgens in COVID-19 was assessed. Further, we describe several drugs suggested as beneficial for COVID-19 treatment related to androgen pathways. Lastly, we looked at androgen sensitivity as a predictor for COVID-19 progression and ongoing clinical trials on androgen suppression therapies as a line of treatment.\n\nSARS-COV2 virus spike proteins utilize Transmembrane protease serine 2 (TMPRSS2) for host entry. Androgen receptors are transcription promoters for TMPRSS2 and can, therefore, facilitate SARS-COV2 entry. Variants in the androgen receptor gene correlate with androgen sensitivity and are implicated in diseases like androgenetic alopecia and prostate cancer, conditions that have been associated with worse COVID-19 outcomes and hospitalization.\n\nAndrogen's TMPRSS2-mediated actions might explain both the low fatalities observed in prepubertal children and the differences between sexes regarding SARS-COV2 infection. Androgen sensitivity may be a critical factor in determining COVID-19 disease severity, and sensitivity tests can, therefore, help in predicting patient outcomes.", "doi": "10.1007/s12020-020-02536-6", "pmid": "33179220", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7657570"}, {"db": "pii", "key": "10.1007/s12020-020-02536-6"}], "notes": [], "created": "2020-11-17T18:06:21.476Z", "modified": "2023-01-13T13:22:07.725Z"}, {"entity": "publication", "iuid": "62b7afd26bb74034adc40ba88cb53b7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/62b7afd26bb74034adc40ba88cb53b7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/62b7afd26bb74034adc40ba88cb53b7e"}}, "title": "SARS-CoV-2, testosterone and frailty in males (PROTEGGIMI): A multidimensional research project.", "authors": [{"family": "Salonia", "given": "Andrea", "initials": "A", "orcid": "0000-0002-0595-7165", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/940b454070ba44e8ad349d3c8f6c06c3.json"}}, {"family": "Corona", "given": "Giovanni", "initials": "G", "orcid": "0000-0002-9894-2885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a16ac7355400404b898586d50aabdb10.json"}}, {"family": "Giwercman", "given": "Aleksander", "initials": "A", "orcid": "0000-0001-5816-0785", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0fd6b6404f946e7aab84d821930a751.json"}}, {"family": "Maggi", "given": "Mario", "initials": "M", "orcid": "0000-0003-3267-4221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/088328c481194b519fe8c3b994b186f8.json"}}, {"family": "Minhas", "given": "Suks", "initials": "S", "orcid": "0000-0001-6516-619X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7f662b0ec134b2197ef8f15deb12468.json"}}, {"family": "Nappi", "given": "Rossella E", "initials": "RE", "orcid": "0000-0002-5216-9882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c88e19ec3901486e9a11f8bfb30a77be.json"}}, {"family": "Sofikitis", "given": "Nikolaos", "initials": "N", "orcid": "0000-0003-1528-4029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/878fcbbf78bf4f98bc7622484e44415d.json"}}, {"family": "Vignozzi", "given": "Linda", "initials": "L", "orcid": "0000-0003-0907-0630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40adf501a0ac4e3ab32759026e837fce.json"}}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Andrology", "issn": "2047-2927", "volume": "9", "issue": "1", "pages": "19-22", "issn-l": null}, "abstract": "Preliminary published data depict a much greater prevalence of males with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) referred for intensive care unit admission and severe sequelae in several countries. In this context, males seem to not only be more susceptible to the infection compared to female subjects, at least in Western countries, but their case fatality rate attributable to SARS-CoV-2 infection is also highest. Therefore, we may speculate that the different hormonal milieu could have a more profound pathophysiological role in association with SARS-CoV-2, with endogenous testosterone leaving men more prone to develop more serious complications related to the SARS-CoV-2 infection. Another option is that SARS-CoV-2 infection per se causes an acute stage of male hypogonadism, the depletion of androgenic action triggering serious or an even fatal course of the disease. Therefore, we strongly advocate the development of a prospective multidimensional andrological translational research project in men, which we called the PROTEGGIMI study. In this Opinion Article, we will not only highlight novel research activity in this area but also invite other researchers and learned scientific societies to join us in our efforts to understand an important and very newly discovered gap in knowledge, which may have serious implications for the lives of millions of men.", "doi": "10.1111/andr.12811", "pmid": "32369678", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-10T07:29:32.686Z", "modified": "2021-12-06T13:08:06.084Z"}, {"entity": "publication", "iuid": "586f3b487ead4831bce4bcfd52919638", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/586f3b487ead4831bce4bcfd52919638.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/586f3b487ead4831bce4bcfd52919638"}}, "title": "Prothrombotic changes in patients with COVID-19 are associated with disease severity and mortality.", "authors": [{"family": "von Meijenfeldt", "given": "Fien A", "initials": "FA"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Adelmeijer", "given": "Jelle", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A"}, {"family": "Rudberg", "given": "Ann-Sofie", "initials": "AS"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Thalin", "given": "Charlotte", "initials": "C"}, {"family": "Lisman", "given": "Ton", "initials": "T", "orcid": "0000-0002-3503-7140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7431e810d13c443ca5dacbf5d368e60b.json"}}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Res Pract Thromb Haemost", "issn": "2475-0379", "issn-l": null, "volume": "5", "issue": "1", "pages": "132-141"}, "abstract": "Patients with severe coronavirus disease 2019 (COVID-19) are at significant risk of thrombotic complications. However, their prothrombotic state is incompletely understood. Therefore, we measured in vivo activation markers of hemostasis, plasma levels of hemostatic proteins, and functional assays of coagulation and fibrinolysis in plasma from patients with COVID-19 and determined their association with disease severity and 30-day mortality.\n\nWe included 102 patients with COVID-19 receiving various levels of respiratory support admitted to general wards, intermediate units, or intensive care units and collected plasma samples shortly after hospital admission.\n\nPatients with COVID-19 with higher respiratory support had increased in vivo activation of coagulation and fibrinolysis, as reflected by higher plasma levels of d-dimer, thrombin-antithrombin, and plasmin-antiplasmin complexes as compared to patients with no to minimal respiratory support and healthy controls. Moreover, the patients with COVID-19 with higher respiratory support exhibited substantial ex vivo thrombin generation and lower ex vivo fibrinolytic capacity, despite higher doses of anticoagulant therapy compared to less severely ill patients. Fibrinogen, factor VIII, and von Willebrand factor levels increased, and ADAMTS13 levels decreased with increasing respiratory support in patients with COVID-19. Low platelet count; low levels of prothrombin, antithrombin, and ADAMTS13; and high levels of von Willebrand factor were associated with short-term mortality.\n\nSevere COVID-19 is associated with prothrombotic changes with increased in vivo activation of coagulation and fibrinolysis, despite anticoagulant therapy.", "doi": "10.1002/rth2.12462", "pmid": "33537537", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "RTH212462"}, {"db": "pmc", "key": "PMC7845083"}], "notes": [], "created": "2021-01-05T09:54:08.916Z", "modified": "2021-12-12T18:06:52.709Z"}, {"entity": "publication", "iuid": "b80e3c19bd144eefa0375ac53985e99d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b80e3c19bd144eefa0375ac53985e99d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b80e3c19bd144eefa0375ac53985e99d"}}, "title": "Priority setting during the COVID-19 pandemic: going beyond vaccines", "authors": [{"family": "Williams", "given": "Iestyn", "initials": "I"}, {"family": "Essue", "given": "Beverley", "initials": "B"}, {"family": "Nouvet", "given": "Elysee", "initials": "E"}, {"family": "Sandman", "given": "Lars", "initials": "L"}, {"family": "Razavi", "given": "S Donya", "initials": "SD"}, {"family": "Noorulhuda", "given": "Mariam", "initials": "M"}, {"family": "Goold", "given": "Susan", "initials": "S"}, {"family": "Danis", "given": "Marion", "initials": "M"}, {"family": "Biemba", "given": "Godfrey", "initials": "G"}, {"family": "Abelson", "given": "Julia", "initials": "J"}, {"family": "Kapiriri", "given": "Lydia", "initials": "L"}], "type": "journal-article", "published": "2021-01-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "1", "pages": "e004686", "issn-l": "2059-7908"}, "abstract": null, "doi": "10.1136/bmjgh-2020-004686", "pmid": "33461979", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-20T14:54:55.855Z", "modified": "2021-01-22T09:17:09.826Z"}, {"entity": "publication", "iuid": "c464dbf3e26d474cb38b3d0e0ffed683", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c464dbf3e26d474cb38b3d0e0ffed683.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c464dbf3e26d474cb38b3d0e0ffed683"}}, "title": "Precision shielding for COVID-19: metrics of assessment and feasibility of deployment.", "authors": [{"family": "Ioannidis", "given": "John P A", "initials": "JPA"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "1", "issn-l": "2059-7908"}, "abstract": "The ability to preferentially protect high-risk groups in COVID-19 is hotly debated. Here, the aim is to present simple metrics of such precision shielding of people at high risk of death after infection by SARS-CoV-2; demonstrate how they can estimated; and examine whether precision shielding was successfully achieved in the first COVID-19 wave. The shielding ratio, S, is defined as the ratio of prevalence of infection among people in a high-risk group versus among people in a low-risk group. The contrasted risk groups examined here are according to age (\u226570 vs <70 years), and institutionalised (nursing home) setting. For age-related precision shielding, data were used from large seroprevalence studies with separate prevalence data for elderly versus non-elderly and with at least 1000 assessed people\u226570 years old. For setting-related precision shielding, data were analysed from 10 countries where information was available on numbers of nursing home residents, proportion of nursing home residents among COVID-19 deaths and overall population infection fatality rate (IFR). Across 17 seroprevalence studies, the shielding ratio S for elderly versus non-elderly varied between 0.4 (substantial shielding) and 1.6 (substantial inverse protection, that is, low-risk people being protected more than high-risk people). Five studies in the USA all yielded S=0.4-0.8, consistent with some shielding being achieved, while two studies in China yielded S=1.5-1.6, consistent with inverse protection. Assuming 25% IFR among nursing home residents, S values for nursing home residents ranged from 0.07 to 3.1. The best shielding was seen in South Korea (S=0.07) and modest shielding was achieved in Israel, Slovenia, Germany and Denmark. No shielding was achieved in Hungary and Sweden. In Belgium (S=1.9), the UK (S=2.2) and Spain (S=3.1), nursing home residents were far more frequently infected than the rest of the population. In conclusion, the experience from the first wave of COVID-19 suggests that different locations and settings varied markedly in the extent to which they protected high-risk groups. Both effective precision shielding and detrimental inverse protection can happen in real-life circumstances. COVID-19 interventions should seek to achieve maximal precision shielding.", "doi": "10.1136/bmjgh-2020-004614", "pmid": "33514595", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-004614"}, {"db": "pmc", "key": "PMC7849322"}], "notes": [], "created": "2021-02-04T18:40:10.775Z", "modified": "2021-02-04T18:40:33.901Z"}, {"entity": "publication", "iuid": "3d2760fc6be84cb79efc1d8324e0cee3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3d2760fc6be84cb79efc1d8324e0cee3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3d2760fc6be84cb79efc1d8324e0cee3"}}, "title": "Impact of the COVID\u201019 pandemic on statistical design and analysis plans for multidomain intervention clinical trials: Experience from World\u2010Wide FINGERS", "authors": [{"family": "R\u00f6hr", "given": "Susanne", "initials": "S"}, {"family": "Arai", "given": "Hidenori", "initials": "H"}, {"family": "Mangialasche", "given": "Francesca", "initials": "F"}, {"family": "Matsumoto", "given": "Nanae", "initials": "N"}, {"family": "Peltonen", "given": "Markku", "initials": "M"}, {"family": "Raman", "given": "Rema", "initials": "R"}, {"family": "Riedel\u2010Heller", "given": "Steffi G", "initials": "SG"}, {"family": "Sakurai", "given": "Takashi", "initials": "T"}, {"family": "Snyder", "given": "Heather M", "initials": "HM"}, {"family": "Sugimoto", "given": "Taiki", "initials": "T"}, {"family": "Carrillo", "given": "Maria", "initials": "M"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Espeland", "given": "Mark A", "initials": "MA"}, {"family": null, "given": "", "initials": ""}], "type": "journal-article", "published": "2021-01-00", "journal": {"title": "Alzheimers Dement (N Y)", "issn": "2352-8737", "issn-l": null, "volume": "7", "issue": "1", "pages": "e12143"}, "abstract": "The coronavirus disease-19 (COVID-19) pandemic presents challenges to the conduct of randomized clinical trials of lifestyle interventions.\r\n\r\nWorld-Wide FINGERS is an international network of clinical trials to assess the impact of multidomain lifestyle intervention on cognitive decline in at-risk adults. Individual trials are tailoring successful approaches from the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) to local cultures and environments. The network convened a forum for researchers to discuss statistical design and analysis issues they faced during the pandemic. We report on experiences of three trials that, at various stages of conduct, altered designs and analysis plans to navigate these issues. We provide recommendations for future trials to consider as they develop and launch behavioral intervention trials.\r\n\r\nThe pandemic led researchers to change recruitment plans, interrupt timelines for assessments and intervention delivery, and move to remote intervention and assessment protocols. The necessity of these changes add emphasis to the importance, in study design and analysis, of intention to treat approaches, flexibility, within-site stratification, interim power projections, and sensitivity analyses.\r\n\r\nRobust approaches to study design and analysis are critical to negotiate issues related to the intervention. The world-wide network of similarly oriented clinical trials will allow us to evaluate the effectiveness of responses to the pandemic across cultures, local environments, and phases of the pandemic.", "doi": "10.1002/trc2.12143", "pmid": "33738333", "labels": {"Category: Public Health": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "TRC212143"}, {"db": "pmc", "key": "PMC7948446"}], "notes": [], "created": "2021-03-22T10:32:35.047Z", "modified": "2021-11-18T12:57:15.265Z"}, {"entity": "publication", "iuid": "3dfd0924e5504124abeb6987b92920b5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3dfd0924e5504124abeb6987b92920b5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3dfd0924e5504124abeb6987b92920b5"}}, "title": "Immune determinants of COVID-19 disease presentation and severity.", "authors": [{"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956", "volume": "27", "issue": "1", "pages": "28-33"}, "abstract": "COVID-19, caused by SARS-CoV-2 infection, is mild to moderate in the majority of previously healthy individuals, but can cause life-threatening disease or persistent debilitating symptoms in some cases. The most important determinant of disease severity is age, with individuals over 65 years having the greatest risk of requiring intensive care, and men are more susceptible than women. In contrast to other respiratory viral infections, young children seem to be less severely affected. It is now clear that mild to severe acute infection is not the only outcome of COVID-19, and long-lasting symptoms are also possible. In contrast to severe acute COVID-19, such 'long COVID' is seemingly more likely in women than in men. Also, postinfectious hyperinflammatory disease has been described as an additional outcome after SARS-CoV-2 infection. Here I discuss our current understanding of the immunological determinants of COVID-19 disease presentation and severity and relate this to known immune-system differences between young and old people and between men and women, and other factors associated with different disease presentations and severity.", "doi": "10.1038/s41591-020-01202-8", "pmid": "33442016", "labels": {"Category: Health": null, "Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-020-01202-8"}], "notes": [], "created": "2021-01-15T11:23:24.748Z", "modified": "2023-07-13T11:26:40.799Z"}, {"entity": "publication", "iuid": "f035e7ee455c4eb08c507a8789e62c5c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f035e7ee455c4eb08c507a8789e62c5c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f035e7ee455c4eb08c507a8789e62c5c"}}, "title": "How two concurrent pandemics put a spoke in the wheel of intensive pig production.", "authors": [{"family": "Millet", "given": "Sam", "initials": "S"}, {"family": "De Smet", "given": "Sarah", "initials": "S"}, {"family": "Knol", "given": "Egbert F", "initials": "EF"}, {"family": "Bee", "given": "Giuseppe", "initials": "G"}, {"family": "Trevisi", "given": "Paolo", "initials": "P"}, {"family": "Vigors", "given": "Stafford", "initials": "S"}, {"family": "Nilsson", "given": "Katja", "initials": "K"}, {"family": "Van Meensel", "given": "Jef", "initials": "J"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Anim Front", "issn": "2160-6064", "volume": "11", "issue": "1", "pages": "14-18", "issn-l": null}, "abstract": null, "doi": "10.1093/af/vfaa051", "pmid": "33575094", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "vfaa051"}, {"db": "pmc", "key": "PMC7863338"}], "notes": [], "created": "2021-02-15T12:54:51.195Z", "modified": "2021-02-15T12:54:51.217Z"}, {"entity": "publication", "iuid": "8c437356108544589e9b347f78ebee8b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c437356108544589e9b347f78ebee8b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c437356108544589e9b347f78ebee8b"}}, "title": "High levels of anxiety during the COVID-19 pandemic as a risk factor of clinical worsening in patients with severe asthma", "authors": [{"family": "Lacwik", "given": "Piotr", "initials": "P"}, {"family": "Szyd\u0142owska", "given": "Dorota", "initials": "D"}, {"family": "Kupczyk", "given": "Maciej", "initials": "M"}, {"family": "Pa\u0142czy\u0144ski", "given": "Cezary", "initials": "C"}, {"family": "Kuna", "given": "Piotr", "initials": "P"}], "type": "journal-article", "published": "2021-01-00", "journal": {"title": "The Journal of Allergy and Clinical Immunology: In Practice", "issn": "2213-2198", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.jaip.2020.12.060", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-15T13:17:12.974Z", "modified": "2021-02-26T08:45:48.448Z"}, {"entity": "publication", "iuid": "47b30bbdaf1c4ae592b17ab88b7f8376", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47b30bbdaf1c4ae592b17ab88b7f8376.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47b30bbdaf1c4ae592b17ab88b7f8376"}}, "title": "Detecting COVID-19 infection hotspots in England using large-scale self-reported data from a mobile application: a prospective, observational study.", "authors": [{"family": "Varsavsky", "given": "Thomas", "initials": "T"}, {"family": "Graham", "given": "Mark S", "initials": "MS"}, {"family": "Canas", "given": "Liane S", "initials": "LS"}, {"family": "Ganesh", "given": "Sajaysurya", "initials": "S"}, {"family": "Capdevila Pujol", "given": "Joan", "initials": "J"}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Murray", "given": "Benjamin", "initials": "B"}, {"family": "Modat", "given": "Marc", "initials": "M"}, {"family": "Jorge Cardoso", "given": "M", "initials": "M"}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Nguyen", "given": "Long H", "initials": "LH"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Gomez", "given": "Maria F", "initials": "MF"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "Davies", "given": "Richard", "initials": "R"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Spector", "given": "Tim D", "initials": "TD"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Lancet Public Health", "issn": "2468-2667", "issn-l": null, "volume": "6", "issue": "1", "pages": "e21-e29"}, "abstract": "As many countries seek to slow the spread of COVID-19 without reimposing national restrictions, it has become important to track the disease at a local level to identify areas in need of targeted intervention.\n\nIn this prospective, observational study, we did modelling using longitudinal, self-reported data from users of the COVID Symptom Study app in England between March 24, and Sept 29, 2020. Beginning on April 28, in England, the Department of Health and Social Care allocated RT-PCR tests for COVID-19 to app users who logged themselves as healthy at least once in 9 days and then reported any symptom. We calculated incidence of COVID-19 using the invited swab (RT-PCR) tests reported in the app, and we estimated prevalence using a symptom-based method (using logistic regression) and a method based on both symptoms and swab test results. We used incidence rates to estimate the effective reproduction number, R(t), modelling the system as a Poisson process and using Markov Chain Monte-Carlo. We used three datasets to validate our models: the Office for National Statistics (ONS) Community Infection Survey, the Real-time Assessment of Community Transmission (REACT-1) study, and UK Government testing data. We used geographically granular estimates to highlight regions with rapidly increasing case numbers, or hotspots.\n\nFrom March 24 to Sept 29, 2020, a total of 2 873 726 users living in England signed up to use the app, of whom 2 842 732 (98\u00b79%) provided valid age information and daily assessments. These users provided a total of 120 192 306 daily reports of their symptoms, and recorded the results of 169 682 invited swab tests. On a national level, our estimates of incidence and prevalence showed a similar sensitivity to changes to those reported in the ONS and REACT-1 studies. On Sept 28, 2020, we estimated an incidence of 15 841 (95% CI 14 023-17 885) daily cases, a prevalence of 0\u00b753% (0\u00b745-0\u00b760), and R(t) of 1\u00b717 (1\u00b715-1\u00b719) in England. On a geographically granular level, on Sept 28, 2020, we detected 15 (75%) of the 20 regions with highest incidence according to government test data.\n\nOur method could help to detect rapid case increases in regions where government testing provision is lower. Self-reported data from mobile applications can provide an agile resource to inform policy makers during a quickly moving pandemic, serving as a complementary resource to more traditional instruments for disease surveillance.\n\nZoe Global, UK Government Department of Health and Social Care, Wellcome Trust, UK Engineering and Physical Sciences Research Council, UK National Institute for Health Research, UK Medical Research Council and British Heart Foundation, Alzheimer's Society, Chronic Disease Research Foundation.", "doi": "10.1016/S2468-2667(20)30269-3", "pmid": "33278917", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7785969"}, {"db": "pii", "key": "S2468-2667(20)30269-3"}], "notes": [], "created": "2020-12-10T09:19:53.222Z", "modified": "2023-06-19T15:27:26.581Z"}, {"entity": "publication", "iuid": "578b0f69f60c4bfe8fe9b74ae778aa67", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/578b0f69f60c4bfe8fe9b74ae778aa67.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/578b0f69f60c4bfe8fe9b74ae778aa67"}}, "title": "Dementia research in 2020: moving forward despite the COVID-19 pandemic", "authors": [{"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Mangialasche", "given": "Francesca", "initials": "F"}], "type": "journal-article", "published": "2021-01-00", "journal": {"title": "The Lancet Neurology", "issn": "1474-4422", "issn-l": null, "volume": "20", "issue": "1", "pages": "3-5"}, "abstract": null, "doi": "10.1016/s1474-4422(20)30453-1", "pmid": "33340483", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1474-4422(20)30453-1"}], "notes": [], "created": "2021-01-10T18:08:57.324Z", "modified": "2021-07-14T07:50:57.871Z"}, {"entity": "publication", "iuid": "d98fd68a9852405a9a40f2927f65eaf4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d98fd68a9852405a9a40f2927f65eaf4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d98fd68a9852405a9a40f2927f65eaf4"}}, "title": "Cancer and Risk of COVID-19 Through a General Community Survey.", "authors": [{"family": "Lee", "given": "Karla A", "initials": "KA", "orcid": "0000-0001-5904-5586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/acab9243ce90490f93e8fc4bb3e7f25f.json"}}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Sikavi", "given": "Daniel R", "initials": "DR"}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Nguyen", "given": "Long H", "initials": "LH"}, {"family": "Bowyer", "given": "Ruth C E", "initials": "RCE"}, {"family": "Cardoso", "given": "M Jorge", "initials": "MJ"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Freidin", "given": "Maxim B", "initials": "MB"}, {"family": "Gomez", "given": "Maria", "initials": "M"}, {"family": "Graham", "given": "Mark", "initials": "M"}, {"family": "Guo", "given": "Chuan-Guo", "initials": "CG"}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Kwon", "given": "Sohee", "initials": "S"}, {"family": "Lo", "given": "Chun-Han", "initials": "CH"}, {"family": "Lochlainn", "given": "Mary Ni", "initials": "MN"}, {"family": "Menni", "given": "Cristina", "initials": "C"}, {"family": "Murray", "given": "Benjamin", "initials": "B"}, {"family": "Mehta", "given": "Raaj", "initials": "R"}, {"family": "Song", "given": "Mingyang", "initials": "M"}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Bataille", "given": "Veronique", "initials": "V"}, {"family": "Varsavsky", "given": "Thomas", "initials": "T"}, {"family": "Visconti", "given": "Alessia", "initials": "A"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Spector", "given": "Tim D", "initials": "TD"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "COPE consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Oncologist", "issn": "1549-490X", "volume": "26", "issue": "1", "pages": "e182-e185", "issn-l": null}, "abstract": "Individuals with cancer may be at high risk for coronavirus disease 2019 (COVID-19) and adverse outcomes. However, evidence from large population-based studies examining whether cancer and cancer-related therapy exacerbates the risk of COVID-19 infection is still limited. Data were collected from the COVID Symptom Study smartphone application since March 29 through May 8, 2020. Among 23,266 participants with cancer and 1,784,293 without cancer, we documented 10,404 reports of a positive COVID-19 test. Compared with participants without cancer, those living with cancer had a 60% increased risk of a positive COVID-19 test. Among patients with cancer, current treatment with chemotherapy or immunotherapy was associated with a 2.2-fold increased risk of a positive test. The association between cancer and COVID-19 infection was stronger among participants >65 years and males. Future studies are needed to identify subgroups by tumor types and treatment regimens who are particularly at risk for COVID-19 infection and adverse outcomes.", "doi": "10.1634/theoncologist.2020-0572", "pmid": "32845538", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7460944"}], "notes": [], "created": "2020-12-07T10:25:23.865Z", "modified": "2023-06-19T15:27:14.731Z"}, {"entity": "publication", "iuid": "21351024191b4d2489d3ed081cb1a9a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/21351024191b4d2489d3ed081cb1a9a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/21351024191b4d2489d3ed081cb1a9a6"}}, "title": "Calling for pan-European commitment for rapid and sustained reduction in SARS-CoV-2 infections", "authors": [{"family": "Priesemann", "given": "Viola", "initials": "V"}, {"family": "Brinkmann", "given": "Melanie M", "initials": "MM"}, {"family": "Ciesek", "given": "Sandra", "initials": "S"}, {"family": "Cuschieri", "given": "Sarah", "initials": "S"}, {"family": "Czypionka", "given": "Thomas", "initials": "T"}, {"family": "Giordano", "given": "Giulia", "initials": "G"}, {"family": "Gurdasani", "given": "Deepti", "initials": "D"}, {"family": "Hanson", "given": "Claudia", "initials": "C"}, {"family": "Hens", "given": "Niel", "initials": "N"}, {"family": "Iftekhar", "given": "Emil", "initials": "E"}, {"family": "Kelly-Irving", "given": "Michelle", "initials": "M"}, {"family": "Klimek", "given": "Peter", "initials": "P"}, {"family": "Kretzschmar", "given": "Mirjam", "initials": "M"}, {"family": "Peichl", "given": "Andreas", "initials": "A"}, {"family": "Perc", "given": "Matja\u017e", "initials": "M"}, {"family": "Sannino", "given": "Francesco", "initials": "F"}, {"family": "Schernhammer", "given": "Eva", "initials": "E"}, {"family": "Schmidt", "given": "Alexander", "initials": "A"}, {"family": "Staines", "given": "Anthony", "initials": "A"}, {"family": "Szczurek", "given": "Ewa", "initials": "E"}], "type": "journal-article", "published": "2021-01-00", "journal": {"title": "Lancet", "issn": "0140-6736", "volume": "397", "issue": "10269", "pages": "92-93", "issn-l": null}, "abstract": null, "doi": "10.1016/s0140-6736(20)32625-8", "pmid": null, "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-10T17:37:45.890Z", "modified": "2021-07-14T07:47:49.897Z"}, {"entity": "publication", "iuid": "e21f5e5fd27d47eaab5a97c944fe7a4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e21f5e5fd27d47eaab5a97c944fe7a4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e21f5e5fd27d47eaab5a97c944fe7a4c"}}, "title": "Behaviour adoption approaches during public health emergencies: implications for the COVID-19 pandemic and beyond.", "authors": [{"family": "Jalloh", "given": "Mohamed F", "initials": "MF"}, {"family": "Nur", "given": "Aasli A", "initials": "AA"}, {"family": "Nur", "given": "Sophia A", "initials": "SA"}, {"family": "Winters", "given": "Maike", "initials": "M"}, {"family": "Bedson", "given": "Jamie", "initials": "J"}, {"family": "Pedi", "given": "Danielle", "initials": "D"}, {"family": "Prybylski", "given": "Dimitri", "initials": "D"}, {"family": "Namageyo-Funa", "given": "Apophia", "initials": "A"}, {"family": "Hageman", "given": "Kathy M", "initials": "KM"}, {"family": "Baker", "given": "Brian J", "initials": "BJ"}, {"family": "Jalloh", "given": "Mohammad B", "initials": "MB"}, {"family": "Eng", "given": "Eugenia", "initials": "E"}, {"family": "Nordenstedt", "given": "Helena", "initials": "H"}, {"family": "Hakim", "given": "Avi J", "initials": "AJ"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "issn-l": "2059-7908", "volume": "6", "issue": "1", "pages": null}, "abstract": "Human behaviour will continue to play an important role as the world grapples with public health threats. In this paper, we draw from the emerging evidence on behaviour adoption during diverse public health emergencies to develop a framework that contextualises behaviour adoption vis-\u00e0-vis a combination of top-down, intermediary and bottom-up approaches. Using the COVID-19 pandemic as a case study, we operationalise the contextual framework to demonstrate how these three approaches differ in terms of their implementation, underlying drivers of action, enforcement, reach and uptake. We illustrate how blended strategies that include all three approaches can help accelerate and sustain protective behaviours that will remain important even when safe and effective vaccines become more widely available. As the world grapples with the COVID-19 pandemic and prepares to respond to (re)emerging public health threats, our contextual framework can inform the design, implementation, tracking and evaluation of comprehensive public health and social measures during health emergencies.", "doi": "10.1136/bmjgh-2020-004450", "pmid": "33514594", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-004450"}, {"db": "pmc", "key": "PMC7849902"}], "notes": [], "created": "2021-02-04T18:43:49.858Z", "modified": "2021-06-18T08:42:50.268Z"}, {"entity": "publication", "iuid": "50d77049587b4cbca713719097ea35b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50d77049587b4cbca713719097ea35b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50d77049587b4cbca713719097ea35b1"}}, "title": "Adjuvanted SARS-CoV-2 spike protein elicits neutralizing antibodies and CD4 T cell responses after a single immunization in mice.", "authors": [{"family": "W\u00f8rzner", "given": "Katharina", "initials": "K"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Schmidt", "given": "Signe Tandrup", "initials": "ST"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Zimmermann", "given": "Julie", "initials": "J"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Christensen", "given": "Dennis", "initials": "D"}, {"family": "Pedersen", "given": "Gabriel Kristian", "initials": "GK"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": "63", "issue": null, "pages": "103197"}, "abstract": "SARS-CoV-2 has caused a global pandemic, infecting millions of people. A safe, effective vaccine is urgently needed and remains a global health priority. Subunit vaccines are used successfully against other viruses when administered in the presence of an effective adjuvant.\n\nWe evaluated three different clinically tested adjuvant systems in combination with the SARS-CoV-2 pre-fusion stabilized (S-2P) spike protein using a one-dose regimen in mice.\n\nWhilst spike protein alone was only weakly immunogenic, the addition of either Aluminum hydroxide, a squalene based oil-in-water emulsion system (SE) or a cationic liposome-based adjuvant significantly enhanced antibody responses against the spike receptor binding domain (RBD). Kinetics of antibody responses differed, with SE providing the most rapid response. Neutralizing antibodies developed after a single immunization in all adjuvanted groups with ID50 titers ranging from 86-4063. Spike-specific CD4 T helper responses were also elicited, comprising mainly of IFN-\u03b3 and IL-17 producing cells in the cationic liposome adjuvanted group, and more IL-5- and IL-10-secreting cells in the AH group.\n\nThese results demonstrate that adjuvanted spike protein subunit vaccine is a viable strategy for rapidly eliciting SARS-CoV-2 neutralizing antibodies and CD4 T cell responses of various qualities depending on the adjuvant used, which can be explored in further vaccine development against COVID-19.\n\nThis work was supported by the European Union Horizon 2020 research and innovation program under grant agreement no. 101003653.", "doi": "10.1016/j.ebiom.2020.103197", "pmid": "33422991", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Funder: H2020": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S2352-3964(20)30573-9"}, {"db": "pmc", "key": "PMC7808923"}], "notes": [], "created": "2021-02-01T14:20:38.962Z", "modified": "2021-09-27T12:30:15.492Z"}, {"entity": "publication", "iuid": "74f80925f92944c2b0a459fc6ba357b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/74f80925f92944c2b0a459fc6ba357b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/74f80925f92944c2b0a459fc6ba357b9"}}, "title": "Optimization Models for Medical Procedures Relocation", "authors": [{"family": "Nguyen", "given": "Linh Anh", "initials": "LA"}, {"family": "Sza\u0142as", "given": "Andrzej", "initials": "A"}], "type": "journal-article", "published": "2021-00-00", "journal": {"title": "Procedia Computer Science", "issn": "1877-0509", "volume": "192", "pages": "2058-2067", "issn-l": null}, "abstract": null, "doi": "10.1016/j.procs.2021.08.212", "pmid": null, "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:49:32.798Z", "modified": "2021-10-11T17:49:32.836Z"}, {"entity": "publication", "iuid": "fec3de621d134d748f62bd75b53bca7f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fec3de621d134d748f62bd75b53bca7f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fec3de621d134d748f62bd75b53bca7f"}}, "title": "High but slightly declining COVID-19 vaccine acceptance and reasons for vaccine acceptance, Finland April to December 2020\u2013Corrigendum", "authors": [{"family": "Hammer", "given": "Harlotte C", "initials": "HC"}, {"family": "Cristea", "given": "Veronica", "initials": "V"}, {"family": "Dub", "given": "Timothee", "initials": "T"}, {"family": "Sivel\u00e4", "given": "Jonas", "initials": "J"}], "type": "journal-article", "published": "2021-00-00", "journal": {"title": "Epidemiol. Infect.", "issn": "0950-2688", "issn-l": null, "volume": "149", "issue": null, "pages": null}, "abstract": null, "doi": "10.1017/s0950268821001217", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-07T05:39:16.056Z", "modified": "2021-06-18T08:31:17.891Z"}, {"entity": "publication", "iuid": "bdb24c0ca1e6408aa905b6e61a296572", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bdb24c0ca1e6408aa905b6e61a296572.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bdb24c0ca1e6408aa905b6e61a296572"}}, "title": "Cardiovascular biomarkers in patients with COVID-19", "authors": [], "type": "journal-article", "published": "2021-00-00", "journal": {"title": "European Heart Journal. Acute Cardiovascular Care", "issn": "2048-8726", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has increased awareness that severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2) may have profound effects on the cardiovascular system. COVID-19 often affects patients with pre-existing cardiac disease, and may trigger acute respiratory distress syndrome (ARDS), venous thromboembolism (VTE), acute myocardial infarction (AMI), and acute heart failure (AHF). However, as COVID-19 is primarily a respiratory infectious disease, there remain substantial uncertainty and controversy whether and how cardiovascular biomarkers should be used in patients with suspected COVID-19. To help clinicians understand the possible value as well as the most appropriate interpretation of cardiovascular biomarkers in COVID-19, it is important to highlight that recent findings regarding the prognostic role of cardiovascular biomarkers in patients hospitalized with COVID-19 are similar to those obtained in studies for pneumonia and ARDS in general. Cardiovascular biomarkers reflecting pathophysiological processes involved in COVID-19/pneumonia and its complications have a role evaluating disease severity, cardiac involvement, and risk of death in COVID-19 as well as in pneumonias caused by other pathogens. First, cardiomyocyte injury, as quantified by cardiac troponin concentrations, and haemodynamic cardiac stress, as quantified by natriuretic peptide concentrations, may occur in COVID-19 as in other pneumonias. The level of those biomarkers correlates with disease severity and mortality. Interpretation of cardiac troponin and natriuretic peptide concentrations as quantitative variables may aid in risk stratification in COVID-19/pneumonia and also will ensure that these biomarkers maintain high diagnostic accuracy for AMI and AHF. Second, activated coagulation as quantified by D-dimers seems more prominent in COVID-19 as in other pneumonias. Due to the central role of endothelitis and VTE in COVID-19, serial measurements of D-dimers may help physicians in the selection of patients for VTE imaging and the intensification of the level of anticoagulation from prophylactic to slightly higher or even therapeutic doses.", "doi": "https://doi.org/10.1093/ehjacc/zuab009", "pmid": "33655301", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-03-03T17:05:20.326Z", "modified": "2021-04-29T16:36:41.229Z"}, {"entity": "publication", "iuid": "bcc82c78df254978bd0fe5cdaa6720fe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bcc82c78df254978bd0fe5cdaa6720fe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bcc82c78df254978bd0fe5cdaa6720fe"}}, "title": "Genetic predisposition to allergic diseases is inversely associated with risk of COVID-19.", "authors": [{"family": "Larsson", "given": "Susanna C", "initials": "SC"}, {"family": "Gill", "given": "Dipender", "initials": "D"}], "type": "letter", "published": "2020-12-31", "journal": {"title": "Allergy", "issn": "1398-9995", "issn-l": "0105-4538", "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1111/all.14728", "pmid": "33382452", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-07T12:06:29.481Z", "modified": "2021-02-26T08:45:48.625Z"}, {"entity": "publication", "iuid": "6587831184184af6a1f19ec09c12c099", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6587831184184af6a1f19ec09c12c099.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6587831184184af6a1f19ec09c12c099"}}, "title": "Eco-epidemiological assessment of the COVID-19 epidemic in China, January-February 2020.", "authors": [{"family": "Byass", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2020-12-31", "journal": {"title": "Glob Health Action", "issn": "1654-9880", "issn-l": null, "volume": "13", "issue": "1", "pages": "1760490"}, "abstract": "Background: The outbreak of COVID-19 in China in early 2020 provides a rich data source for exploring the ecological determinants of this new infection, which may be of relevance as the pandemic develops.Objectives: Assessing the spread of the COVID-19 across China, in relation to associations between cases and ecological factors including population density, temperature, solar radiation and precipitation.Methods: Open-access COVID-19 case data include 18,069 geo-located cases in China during January and February 2020, which were mapped onto a 0.25\u00b0 latitude/longitude grid together with population and weather data (temperature, solar radiation and precipitation). Of 15,539 grid cells, 559 (3.6%) contained at least one case, and these were used to construct a Poisson regression model of cell-weeks. Weather parameters were taken for the preceding week given the established 5-7 day incubation period for COVID-19. The dependent variable in the Poisson model was incident cases per cell-week and exposure was cell population, allowing for clustering of cells over weeks, to give incidence rate ratios.Results: The overall COVID-19 incidence rate in cells with confirmed cases was 0.12 per 1,000. There was a single confirmed case in 113/559 (20.2%) of cells, while two grid cells recorded over 1,000 confirmed cases. Weekly means of maximum daily temperature varied from -28.0\u00b0C to 30.1\u00b0C, minimum daily temperature from -42.4\u00b0C to 23.0\u00b0C, maximum solar radiation from 0.04 to 2.74 MJm-2 and total precipitation from 0 to 72.6 mm. Adjusted incidence rate ratios suggested brighter, warmer and drier conditions were associated with lower incidence.Conclusion: Though not demonstrating cause and effect, there were appreciable associations between weather and COVID-19 incidence during the epidemic in China. This does not mean the pandemic will go away with summer weather but demonstrates the importance of using weather conditions in understanding and forecasting the spread of COVID-19.", "doi": "10.1080/16549716.2020.1760490", "pmid": "32404043", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7269037"}], "notes": [], "created": "2020-12-10T08:44:08.879Z", "modified": "2021-02-26T08:46:59.993Z"}, {"entity": "publication", "iuid": "7a40667eeaac4d1cb2751b5cb03d7639", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a40667eeaac4d1cb2751b5cb03d7639.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a40667eeaac4d1cb2751b5cb03d7639"}}, "title": "A direct RT-qPCR approach to test large numbers of individuals for SARS-CoV-2.", "authors": [{"family": "Maricic", "given": "Tomislav", "initials": "T"}, {"family": "Nickel", "given": "Olaf", "initials": "O"}, {"family": "Aximu-Petri", "given": "Ayinuer", "initials": "A"}, {"family": "Essel", "given": "Elena", "initials": "E"}, {"family": "Gansauge", "given": "Marie", "initials": "M"}, {"family": "Kanis", "given": "Philipp", "initials": "P"}, {"family": "Macak", "given": "Dominik", "initials": "D"}, {"family": "Richter", "given": "Julia", "initials": "J"}, {"family": "Riesenberg", "given": "Stephan", "initials": "S"}, {"family": "Bokelmann", "given": "Lukas", "initials": "L"}, {"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "Meyer", "given": "Matthias", "initials": "M"}, {"family": "Borte", "given": "Stephan", "initials": "S"}, {"family": "P\u00e4\u00e4bo", "given": "Svante", "initials": "S"}], "type": "journal article", "published": "2020-12-31", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "15", "issue": "12", "pages": "e0244824", "issn-l": "1932-6203"}, "abstract": "SARS-CoV-2 causes substantial morbidity and mortality in elderly and immunocompromised individuals, particularly in retirement homes, where transmission from asymptomatic staff and visitors may introduce the infection. Here we present a cheap and fast screening method based on direct RT-qPCR to detect SARS-CoV-2 in single or pooled gargle lavages (\"mouthwashes\"). This method detects individuals with large viral loads (Ct\u226429) and we use it to test all staff at a nursing home daily over a period of three weeks in order to reduce the risk that the infection penetrates the facility. This or similar approaches can be implemented to protect hospitals, nursing homes and other institutions in this and future viral epidemics.", "doi": "10.1371/journal.pone.0244824", "pmid": "33382830", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0244824#sec013", "description": "All data are available in the supplementary information"}], "notes": [], "created": "2021-01-07T11:53:04.600Z", "modified": "2021-11-18T12:42:52.436Z"}, {"entity": "publication", "iuid": "f15874bd4c424661b8db73c43a1afd31", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f15874bd4c424661b8db73c43a1afd31.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f15874bd4c424661b8db73c43a1afd31"}}, "title": "Time Trends of the Public\u2019s Attention Toward Suicide During the COVID-19 Pandemic: Retrospective, Longitudinal Time-Series Study", "authors": [{"family": "Burnett", "given": "Dayle", "initials": "D"}, {"family": "Eapen", "given": "Valsamma", "initials": "V"}, {"family": "Lin", "given": "Ping I", "initials": "PI"}], "type": "journal-article", "published": "2020-12-30", "journal": {"title": "JMIR Public Health Surveill", "issn": "2369-2960", "volume": "6", "issue": "4", "pages": "e24694", "issn-l": null}, "abstract": null, "doi": "10.2196/24694", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-10T18:13:57.524Z", "modified": "2021-02-26T08:47:00.305Z"}, {"entity": "publication", "iuid": "95a37cbd41734367bc2b23e615569b9f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95a37cbd41734367bc2b23e615569b9f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95a37cbd41734367bc2b23e615569b9f"}}, "title": "Integrating the social sciences in epidemic preparedness and response: A strategic framework to strengthen capacities and improve Global Health security.", "authors": [{"family": "Bardosh", "given": "Kevin Louis", "initials": "KL"}, {"family": "de Vries", "given": "Daniel H", "initials": "DH"}, {"family": "Abramowitz", "given": "Sharon", "initials": "S"}, {"family": "Thorlie", "given": "Adama", "initials": "A"}, {"family": "Cremers", "given": "Lianne", "initials": "L"}, {"family": "Kinsman", "given": "John", "initials": "J"}, {"family": "Stellmach", "given": "Darryl", "initials": "D"}], "type": "journal article", "published": "2020-12-30", "journal": {"title": "Global Health", "issn": "1744-8603", "volume": "16", "issue": "1", "pages": "120", "issn-l": "1744-8603"}, "abstract": "The importance of integrating the social sciences in epidemic preparedness and response has become a common feature of infectious disease policy and practice debates. However to date, this integration remains inadequate, fragmented and under-funded, with limited reach and small initial investments. Based on data collected prior to the COVID-19 pandemic, in this paper we analysed the variety of knowledge, infrastructure and funding gaps that hinder the full integration of the social sciences in epidemics and present a strategic framework for addressing them.\n\nSenior social scientists with expertise in public health emergencies facilitated expert deliberations, and conducted 75 key informant interviews, a consultation with 20 expert social scientists from Africa, Asia and Europe, 2 focus groups and a literature review of 128 identified high-priority peer reviewed articles. We also analysed 56 interviews from the Ebola 100 project, collected just after the West African Ebola epidemic. Analysis was conducted on gaps and recommendations. These were inductively classified according to various themes during two group prioritization exercises. The project was conducted between February and May 2019. Findings from the report were used to inform strategic prioritization of global investments in social science capacities for health emergencies.\n\nOur analysis consolidated 12 knowledge and infrastructure gaps and 38 recommendations from an initial list of 600 gaps and 220 recommendations. In developing our framework, we clustered these into three areas: 1) Recommendations to improve core social science response capacities, including investments in: human resources within response agencies; the creation of social science data analysis capacities at field and global level; mechanisms for operationalizing knowledge; and a set of rapid deployment infrastructures; 2) Recommendations to strengthen applied and basic social sciences, including the need to: better define the social science agenda and core competencies; support innovative interdisciplinary science; make concerted investments in developing field ready tools and building the evidence-base; and develop codes of conduct; and 3) Recommendations for a supportive social science ecosystem, including: the essential foundational investments in institutional development; training and capacity building; awareness-raising activities with allied disciplines; and lastly, support for a community of practice.\n\nComprehensively integrating social science into the epidemic preparedness and response architecture demands multifaceted investments on par with allied disciplines, such as epidemiology and virology. Building core capacities and competencies should occur at multiple levels, grounded in country-led capacity building. Social science should not be a parallel system, nor should it be \"siloed\" into risk communication and community engagement. Rather, it should be integrated across existing systems and networks, and deploy interdisciplinary knowledge \"transversally\" across all preparedness and response sectors and pillars. Future work should update this framework to account for the impact of the COVID-19 pandemic on the institutional landscape.", "doi": "10.1186/s12992-020-00652-6", "pmid": "33380341", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12992-020-00652-6"}, {"db": "pmc", "key": "PMC7772799"}], "notes": [], "created": "2021-01-07T12:10:19.942Z", "modified": "2021-02-26T08:47:00.083Z"}, {"entity": "publication", "iuid": "af36f6a1c29d4c64bd3c8e3c58546657", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/af36f6a1c29d4c64bd3c8e3c58546657.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/af36f6a1c29d4c64bd3c8e3c58546657"}}, "title": "COVID-19 spatiotemporal research with workflow-based data analysis.", "authors": [{"family": "Chintala", "given": "Srikar", "initials": "S"}, {"family": "Dutta", "given": "Ritvik", "initials": "R"}, {"family": "Tadmor", "given": "Doron", "initials": "D"}], "type": "journal article", "published": "2020-12-30", "journal": {"title": "Infect Genet Evol", "issn": "1567-7257", "volume": null, "issue": null, "pages": "104701", "issn-l": null}, "abstract": "Given the pertinence and acceleration of the spread of COVID-19, there is an increased need for the replicability of data models to verify the veracity of models and visualize important data. Most of these visualizations lack reproducibility, credibility, or accuracy, and are static, which makes it difficult to analyze the spread over time. Furthermore, most current visualizations depicting the spread of COVID-19 are at a global or country level, meaning there is a dearth of regional analysis within a country. Keeping these issues in mind, a replicable, efficient, and simple method to generate regional COVID-19 visualizations mapped with time was created by using the KNIME software, an open-source data analytics platform that can create user-friendly applications or workflows. For this analysis, Albania, Sweden, Ukraine, Denmark, Russia, India, and Australia were closely observed. Among the maps generated for the aforementioned countries, it was noticed that regions with a high population or high population density were often the epicenters within their respective country. The regions caused the virus to spread to their neighboring regions: kickstarting the \"domino effect\", leading to the infection of another region until the country is overwhelmed with cases-what we call a proximity trend. These dynamic maps are crucial to fighting the pandemic because they can provide insight as to how COVID-19 spreads by providing researchers or officials with an accurate and insightful tool to aid their analysis. By being able to visualize the spread, health and government officials can dive deeper to identify the sources of transmission and attempt to stop or reverse them accordingly.", "doi": "10.1016/j.meegid.2020.104701", "pmid": "33387692", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S1567-1348(20)30532-3"}, {"db": "pmc", "key": "PMC7773529"}], "notes": [], "created": "2021-01-07T11:21:45.756Z", "modified": "2021-02-26T08:46:13.433Z"}, {"entity": "publication", "iuid": "2b3f61fe73ac49f0b91cc6fc002bcc7c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b3f61fe73ac49f0b91cc6fc002bcc7c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b3f61fe73ac49f0b91cc6fc002bcc7c"}}, "title": "ACE2: the molecular doorway to SARS-CoV-2.", "authors": [{"family": "Medina-Enr\u00edquez", "given": "Miriam Marlene", "initials": "MM"}, {"family": "Lopez-Le\u00f3n", "given": "Sandra", "initials": "S"}, {"family": "Carlos-Escalante", "given": "Jos\u00e9 Alberto", "initials": "JA"}, {"family": "Aponte-Torres", "given": "Zuleika", "initials": "Z"}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Wegman-Ostrosky", "given": "Talia", "initials": "T"}], "type": "journal article", "published": "2020-12-30", "journal": {"title": "Cell Biosci", "issn": "2045-3701", "volume": "10", "issue": "1", "pages": "148", "issn-l": null}, "abstract": "The angiotensin-converting enzyme 2 (ACE2) is the host functional receptor for the new virus SARS-CoV-2 causing Coronavirus Disease 2019. ACE2 is expressed in 72 different cell types. Some factors that can affect the expression of the ACE2 are: sex, environment, comorbidities, medications (e.g. anti-hypertensives) and its interaction with other genes of the renin-angiotensin system and other pathways. Different factors can affect the risk of infection of SARS-CoV-2 and determine the severity of the symptoms. The ACE2 enzyme is a negative regulator of RAS expressed in various organ systems. It is with immunity, inflammation, increased coagulopathy, and cardiovascular disease. In this review, we describe the genetic and molecular functions of the ACE2 receptor and its relation with the physiological and pathological conditions to better understand how this receptor is involved in the pathogenesis of COVID-19. In addition, it reviews the different comorbidities that interact with SARS-CoV-2 in which also ACE2 plays an important role. It also describes the different factors that interact with the virus that have an influence in the expression and functional activities of the receptor. The goal is to provide the reader with an understanding of the complexity and importance of this receptor.", "doi": "10.1186/s13578-020-00519-8", "pmid": "33380340", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13578-020-00519-8"}, {"db": "pmc", "key": "PMC7772801"}], "notes": [], "created": "2021-01-07T12:14:04.788Z", "modified": "2021-01-07T12:14:04.810Z"}, {"entity": "publication", "iuid": "881a0630ec5d4fc8bfdd76a818723b0c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/881a0630ec5d4fc8bfdd76a818723b0c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/881a0630ec5d4fc8bfdd76a818723b0c"}}, "title": "Plasma renin activity has a complex prognostic role in patients with acute coronary syndromes.", "authors": [{"family": "Hartford", "given": "Marianne", "initials": "M"}, {"family": "Herlitz", "given": "Hans", "initials": "H"}, {"family": "Perers", "given": "Elisabeth", "initials": "E"}, {"family": "Karlsson", "given": "Thomas", "initials": "T"}, {"family": "Herlitz", "given": "Johan", "initials": "J"}, {"family": "Persson", "given": "Anita", "initials": "A"}, {"family": "Caidahl", "given": "Kenneth", "initials": "K"}], "type": "journal article", "published": "2020-12-29", "journal": {"title": "Int J Cardiol", "issn": "1874-1754", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Plasma renin activity (PRA) has been related to all-cause mortality and cardiovascular events in patients with cardiovascular disease. However, data from patients with acute coronary syndromes (ACS) are sparse.\r\n\r\nDetermination of PRA was made in 550 patients with ACS, including a subgroup of 287 patients not on treatment with angiotensin converting enzyme inhibitors, angiotensin receptor blockers or diuretics, and without heart failure. We evaluated the relations between PRA and all-cause mortality after three years and long-term, and to cardiovascular events after median 8.7 years. Adjustments were made for variables that influenced the hazard ratio (HR) > 5% for the relation between PRA and outcome.\r\n\r\nBaseline PRA was associated with all-cause mortality during three-years (unadjusted HR 1.74 per 1 SD increase in logarithmically transformed PRA; 95% confidence interval (CI) 1.39-2.16, p < 0.0001) and long-term (HR 1.12, CI 1.00-1.25, p = 0.046). After adjustments, only the three-year association remained significant. In unadjusted analyses, PRA was associated with cardiovascular death, but not with nonfatal cardiovascular events. In the subgroup there was an inverse relation between PRA and long-term all-cause mortality.\r\n\r\nHigher PRA was a significant independent predictor of all-cause mortality after three years, but not at long-term follow-up and not significantly associated with cardiovascular incidence. The renin-angiotensin-system pathophysiology is of great interest, not least due to its association with the COVID-19 pandemic. Our findings indicate a need for further research on the prognostic/predictive aspects of the renin-angiotensin-system in ACS.", "doi": "10.1016/j.ijcard.2020.12.062", "pmid": "33385419", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0167-5273(20)34310-2"}], "notes": [], "created": "2021-01-07T11:37:34.979Z", "modified": "2021-02-26T08:45:48.437Z"}, {"entity": "publication", "iuid": "7d408a34c8ea4368a9fa5d59d4194de1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d408a34c8ea4368a9fa5d59d4194de1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d408a34c8ea4368a9fa5d59d4194de1"}}, "title": "Paediatricians face challenging times as COVID\u201019 can cloud other diagnoses and lead to treatment delays", "authors": [{"family": "Marits", "given": "Ann Katrine", "initials": "AK"}, {"family": "Fischler", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Chromek", "given": "Milan", "initials": "M"}], "type": "journal-article", "published": "2020-12-29", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1111/apa.15725", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-08T09:09:04.389Z", "modified": "2021-02-26T08:45:48.390Z"}, {"entity": "publication", "iuid": "9981ed7c4c3f402ea9ae9ebd7df56738", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9981ed7c4c3f402ea9ae9ebd7df56738.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9981ed7c4c3f402ea9ae9ebd7df56738"}}, "title": "Broadly Active Antiviral Compounds Disturb Zika Virus Progeny Release Rescuing Virus-Induced Toxicity in Brain Organoids.", "authors": [{"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Tampere", "given": "Marianna", "initials": "M"}, {"family": "Pronk", "given": "Robin", "initials": "R"}, {"family": "Wallner", "given": "Olov", "initials": "O"}, {"family": "Falk", "given": "Anna", "initials": "A"}, {"family": "Warpman Berglund", "given": "Ulrika", "initials": "U"}, {"family": "Helleday", "given": "Thomas", "initials": "T"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Puumalainen", "given": "Marjo-Riitta", "initials": "MR"}], "type": "journal article", "published": "2020-12-29", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "1", "pages": "37", "issn-l": "1999-4915"}, "abstract": "RNA viruses have gained plenty of attention during recent outbreaks of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Zika virus (ZIKV), and Ebola virus. ZIKV is a vector borne Flavivirus that is spread by mosquitoes and it mainly infects neuronal progenitor cells. One hallmark of congenital ZIKV disease is a reduced brain size in fetuses, leading to severe neurological defects. The World Health Organization (WHO) is urging the development of new antiviral treatments against ZIKV, as there are no efficient countermeasures against ZIKV disease. Previously, we presented a new class of host-targeting antivirals active against a number of pathogenic RNA viruses, such as SARS-CoV-2. Here, we show the transfer of the image-based phenotypic antiviral assay to ZIKV-infected brain cells, followed by mechanism-of-action studies and a proof-of-concept study in a three-dimensional (3D) organoid model. The novel antiviral compounds showed a therapeutic window against ZIKV in several cell models and rescued ZIKV-induced neurotoxicity in brain organoids. The compound's mechanism-of-action was pinpointed to late steps in the virus life cycle, impairing the formation of new virus particles. Collectively, in this study, we expand the antiviral activity of new small molecule inhibitors to a new virus class of Flaviviruses, but also uncover compounds' mechanism of action, which are important for the further development of antivirals.", "doi": "10.3390/v13010037", "pmid": "33383826", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: H2020": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "v13010037"}, {"db": "URL", "key": "https://www.mdpi.com/1999-4915/13/1/37/s1", "description": "The effect of novel antiviral compounds against ZIKV in several cell models; other supporting data"}], "notes": [], "created": "2021-01-07T11:49:35.800Z", "modified": "2021-02-26T08:45:03.173Z"}, {"entity": "publication", "iuid": "e990290ae5f6422b9b724ae8ee6e58e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e990290ae5f6422b9b724ae8ee6e58e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e990290ae5f6422b9b724ae8ee6e58e1"}}, "title": "Seropositivity in blood donors and pregnant women during 9-months of SARS-CoV-2 transmission in Stockholm, Sweden", "authors": [{"family": "Dopico", "given": "Xaquin Castro", "initials": "XC"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Christian", "given": "Murray", "initials": "M"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Grinberg", "given": "Nastasiya F", "initials": "NF"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Mcinerney", "given": "Gerald M", "initials": "GM"}, {"family": "Allander", "given": "Tobias", "initials": "T"}, {"family": "Wallace", "given": "Chris", "initials": "C"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}], "type": "posted-content", "published": "2020-12-26", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.24.20248821", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Funder: H2020": null, "Category: Health": null, "Category: Serology": null}, "xrefs": [{"db": "URL", "key": "https://github.com/MurrellGroup/DiscriminativeSeroprevalence/", "description": "Data and analysis code (Ben Murrell Group)"}, {"db": "URL", "key": "https://github.com/chr1swallace/seroprevalence-paper", "description": "Data and analysis code (Chris Wallace Group)"}], "notes": [], "created": "2021-01-07T16:43:04.878Z", "modified": "2021-04-23T09:09:33.692Z"}, {"entity": "publication", "iuid": "3aeb13b25a9d4e3da6ffa6db5a446fe7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3aeb13b25a9d4e3da6ffa6db5a446fe7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3aeb13b25a9d4e3da6ffa6db5a446fe7"}}, "title": "Adverse effects of hydroxychloroquine and azithromycin on contractility and arrhythmogenicity revealed by human engineered cardiac tissues.", "authors": [{"family": "Wong", "given": "Andy On-Tik", "initials": "AO"}, {"family": "Gurung", "given": "Bimal", "initials": "B"}, {"family": "Wong", "given": "Wing Sum", "initials": "WS"}, {"family": "Mak", "given": "Suet Yee", "initials": "SY"}, {"family": "Tse", "given": "Wan Wai", "initials": "WW"}, {"family": "Li", "given": "Chloe M", "initials": "CM"}, {"family": "Lieu", "given": "Deborah K", "initials": "DK"}, {"family": "Costa", "given": "Kevin D", "initials": "KD"}, {"family": "Li", "given": "Ronald A", "initials": "RA"}, {"family": "Hajjar", "given": "Roger J", "initials": "RJ"}], "type": "journal article", "published": "2020-12-26", "journal": {"title": "J Mol Cell Cardiol", "issn": "1095-8584", "volume": "153", "issue": null, "pages": "106-110", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic as declared by World Health Organization (WHO). In the absence of an effective treatment in early 2020, different drugs with unknown effectiveness, including antimalarial hydroxychloroquine (HCQ), with or without concurrent administration with azithromycin (AZM), have been tested for treating COVID-19 patients with developed pneumonia. However, the efficacy and safety of HCQ and/or AZM have been questioned by recent clinical reports. Direct effects of these drugs on the human heart remain very poorly defined. To better understand the mechanisms of action of HCQ +/- AZM, we employed bioengineered human ventricular cardiac tissue strip (hvCTS) and anisotropic sheet (hvCAS) assays, made with human pluripotent stem cell (hPSC)-derived ventricular cardiomyocytes (hvCMs), which have been designed for measuring cardiac contractility and electrophysiology, respectively. Our hvCTS experiments showed that AZM induced a dose-dependent negative inotropic effect which could be aggravated by HCQ; electrophysiologically, as revealed by the hvCAS platform, AZM prolonged action potentials and induced spiral wave formations. Collectively, our data were consistent with reported clinical risks of HCQ and AZM on QTc prolongation/ventricular arrhythmias and development of heart failure. In conclusion, our study exposed the risks of HCQ/AZM administration while providing mechanistic insights for their toxicity. Our bioengineered human cardiac tissue constructs therefore provide a useful platform for screening cardiac safety and efficacy when developing therapeutics against COVID-19.", "doi": "10.1016/j.yjmcc.2020.12.014", "pmid": "33373642", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S0022-2828(20)30354-0"}, {"db": "pmc", "key": "PMC7765761"}], "notes": [], "created": "2021-01-07T12:32:02.760Z", "modified": "2021-02-26T08:45:25.850Z"}, {"entity": "publication", "iuid": "13a67022e71646239744a33435e1b112", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13a67022e71646239744a33435e1b112.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13a67022e71646239744a33435e1b112"}}, "title": "Risk of depression, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: a multinational network cohort study.", "authors": [{"family": "Lane", "given": "Jennifer C E", "initials": "JCE"}, {"family": "Weaver", "given": "James", "initials": "J"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "Abrahao", "given": "Maria Tereza F", "initials": "MTF"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Biedermann", "given": "Patricia", "initials": "P"}, {"family": "Banda", "given": "Juan M", "initials": "JM"}, {"family": "Burn", "given": "Edward", "initials": "E"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "Fister", "given": "Kristina", "initials": "K"}, {"family": "Hardin", "given": "Jill", "initials": "J"}, {"family": "Hester", "given": "Laura", "initials": "L"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Kaas-Hansen", "given": "Benjamin Skov", "initials": "BS"}, {"family": "Khosla", "given": "Sajan", "initials": "S"}, {"family": "Kolovos", "given": "Spyros", "initials": "S"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Makadia", "given": "Rupa", "initials": "R"}, {"family": "Mehta", "given": "Paras P", "initials": "PP"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Morgan-Stewart", "given": "Henry", "initials": "H"}, {"family": "Mosseveld", "given": "Mees", "initials": "M"}, {"family": "Newby", "given": "Danielle", "initials": "D"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Woong Park", "given": "Rae", "initials": "R"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A"}, {"family": "Rao", "given": "Gowtham A", "initials": "GA"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Rijnbeek", "given": "Peter", "initials": "P"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Shoaibi", "given": "Azza", "initials": "A"}, {"family": "Spotnitz", "given": "Matthew", "initials": "M"}, {"family": "Vignesh", "given": "Subbian", "initials": "S"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Vizcaya", "given": "David", "initials": "D"}, {"family": "Wen", "given": "Haini", "initials": "H"}, {"family": "de Wilde", "given": "Marcel", "initials": "M"}, {"family": "Xie", "given": "Junqing", "initials": "J"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Lovestone", "given": "Simon", "initials": "S"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "OHDSI-COVID-19 consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2020-12-25", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "volume": null, "issue": null, "issn-l": null}, "abstract": "Concern has been raised in the rheumatology community regarding recent regulatory warnings that HCQ used in the coronavirus disease 2019 pandemic could cause acute psychiatric events. We aimed to study whether there is risk of incident depression, suicidal ideation or psychosis associated with HCQ as used for RA.\n\nWe performed a new-user cohort study using claims and electronic medical records from 10 sources and 3 countries (Germany, UK and USA). RA patients \u226518 years of age and initiating HCQ were compared with those initiating SSZ (active comparator) and followed up in the short (30 days) and long term (on treatment). Study outcomes included depression, suicide/suicidal ideation and hospitalization for psychosis. Propensity score stratification and calibration using negative control outcomes were used to address confounding. Cox models were fitted to estimate database-specific calibrated hazard ratios (HRs), with estimates pooled where I2 <40%.\n\nA total of 918 144 and 290 383 users of HCQ and SSZ, respectively, were included. No consistent risk of psychiatric events was observed with short-term HCQ (compared with SSZ) use, with meta-analytic HRs of 0.96 (95% CI 0.79, 1.16) for depression, 0.94 (95% CI 0.49, 1.77) for suicide/suicidal ideation and 1.03 (95% CI 0.66, 1.60) for psychosis. No consistent long-term risk was seen, with meta-analytic HRs of 0.94 (95% CI 0.71, 1.26) for depression, 0.77 (95% CI 0.56, 1.07) for suicide/suicidal ideation and 0.99 (95% CI 0.72, 1.35) for psychosis.\n\nHCQ as used to treat RA does not appear to increase the risk of depression, suicide/suicidal ideation or psychosis compared with SSZ. No effects were seen in the short or long term. Use at a higher dose or for different indications needs further investigation.\n\nRegistered with EU PAS (reference no. EUPAS34497; http://www.encepp.eu/encepp/viewResource.htm? id=34498). The full study protocol and analysis source code can be found at https://github.com/ohdsi-studies/Covid19EstimationHydroxychloroquine2.", "doi": "10.1093/rheumatology/keaa771", "pmid": "33367863", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://github.com/ohdsi-studies/Covid19EstimationHydroxychloroquine2", "description": "Data aggregated by data source"}], "notes": [], "created": "2021-01-07T13:36:58.823Z", "modified": "2021-04-26T17:59:42.486Z"}, {"entity": "publication", "iuid": "6add60296d9a47959698548642400e61", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6add60296d9a47959698548642400e61.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6add60296d9a47959698548642400e61"}}, "title": "Recent smell loss is the best predictor of COVID-19 among individuals with recent respiratory symptoms", "authors": [{"family": "Gerkin", "given": "Richard C", "initials": "RC"}, {"family": "Ohla", "given": "Kathrin", "initials": "K"}, {"family": "Veldhuizen", "given": "Maria G", "initials": "MG"}, {"family": "Joseph", "given": "Paule V", "initials": "PV"}, {"family": "Kelly", "given": "Christine E", "initials": "CE"}, {"family": "Bakke", "given": "Alyssa J", "initials": "AJ"}, {"family": "Steele", "given": "Kimberley E", "initials": "KE"}, {"family": "Farruggia", "given": "Michael C", "initials": "MC"}, {"family": "Pellegrino", "given": "Robert", "initials": "R"}, {"family": "Pepino", "given": "Marta Y", "initials": "MY"}, {"family": "Bouysset", "given": "C\u00e9dric", "initials": "C"}, {"family": "Soler", "given": "Graciela M", "initials": "GM"}, {"family": "Pereda-Loth", "given": "Veronica", "initials": "V"}, {"family": "Dibattista", "given": "Michele", "initials": "M"}, {"family": "Cooper", "given": "Keiland W", "initials": "KW"}, {"family": "Croijmans", "given": "Ilja", "initials": "I"}, {"family": "Di Pizio", "given": "Antonella", "initials": "A"}, {"family": "Ozdener", "given": "M Hakan", "initials": "MH"}, {"family": "Fjaeldstad", "given": "Alexander W", "initials": "AW"}, {"family": "Lin", "given": "Cailu", "initials": "C"}, {"family": "Sandell", "given": "Mari A", "initials": "MA"}, {"family": "Singh", "given": "Preet B", "initials": "PB"}, {"family": "Brindha", "given": "V Evelyn", "initials": "VE"}, {"family": "Olsson", "given": "Shannon B", "initials": "SB"}, {"family": "Saraiva", "given": "Luis R", "initials": "LR"}, {"family": "Ahuja", "given": "Gaurav", "initials": "G"}, {"family": "Alwashahi", "given": "Mohammed K", "initials": "MK"}, {"family": "Bhutani", "given": "Surabhi", "initials": "S"}, {"family": "D\u2019Errico", "given": "Anna", "initials": "A"}, {"family": "Fornazieri", "given": "Marco A", "initials": "MA"}, {"family": "Golebiowski", "given": "J\u00e9r\u00f4me", "initials": "J"}, {"family": "Hwang", "given": "Liang Dar", "initials": "LD"}, {"family": "\u00d6zt\u00fcrk", "given": "Lina", "initials": "L"}, {"family": "Roura", "given": "Eugeni", "initials": "E"}, {"family": "Spinelli", "given": "Sara", "initials": "S"}, {"family": "Whitcroft", "given": "Katherine L", "initials": "KL"}, {"family": "Faraji", "given": "Farhoud", "initials": "F"}, {"family": "Fischmeister", "given": "Florian PhS", "initials": "FP"}, {"family": "Heinbockel", "given": "Thomas", "initials": "T"}, {"family": "Hsieh", "given": "Julien W", "initials": "JW"}, {"family": "Huart", "given": "Caroline", "initials": "C"}, {"family": "Konstantinidis", "given": "Iordanis", "initials": "I"}, {"family": "Menini", "given": "Anna", "initials": "A"}, {"family": "Morini", "given": "Gabriella", "initials": "G"}, {"family": "Olofsson", "given": "Jonas K", "initials": "JK"}, {"family": "Philpott", "given": "Carl M", "initials": "CM"}, {"family": "Pierron", "given": "Denis", "initials": "D"}, {"family": "Shields", "given": "Vonnie D C", "initials": "VDC"}, {"family": "Voznessenskaya", "given": "Vera V", "initials": "VV"}, {"family": "Albayay", "given": "Javier", "initials": "J"}, {"family": "Altundag", "given": "Aytug", "initials": "A"}, {"family": "Bensafi", "given": "Moustafa", "initials": "M"}, {"family": "Bock", "given": "Mar\u00eda Adelaida", "initials": "MA"}, {"family": "Calcinoni", "given": "Orietta", "initials": "O"}, {"family": "Fredborg", "given": "William", "initials": "W"}, {"family": "Laudamiel", "given": "Christophe", "initials": "C"}, {"family": "Lim", "given": "Juyun", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Johan N", "initials": "JN"}, {"family": "Macchi", "given": "Alberto", "initials": "A"}, {"family": "Meyer", "given": "Pablo", "initials": "P"}, {"family": "Moein", "given": "Shima T", "initials": "ST"}, {"family": "Santamar\u00eda", "given": "Enrique", "initials": "E"}, {"family": "Sengupta", "given": "Debarka", "initials": "D"}, {"family": "Dominguez", "given": "Paloma Rohlfs", "initials": "PR"}, {"family": "Yanik", "given": "H\u00fcseyin", "initials": "H"}, {"family": "Hummel", "given": "Thomas", "initials": "T"}, {"family": "Hayes", "given": "John E", "initials": "JE"}, {"family": "Reed", "given": "Danielle R", "initials": "DR"}, {"family": "Niv", "given": "Masha Y", "initials": "MY"}, {"family": "Munger", "given": "Steven D", "initials": "SD"}, {"family": "Parma", "given": "Valentina", "initials": "V"}, {"family": "Boesveldt", "given": "Sanne", "initials": "S"}, {"family": "de Groot", "given": "Jasper H B", "initials": "JHB"}, {"family": "Dinnella", "given": "Caterina", "initials": "C"}, {"family": "Freiherr", "given": "Jessica", "initials": "J"}, {"family": "Laktionova", "given": "Tatiana", "initials": "T"}, {"family": "Marino", "given": "Sajidxa", "initials": "S"}, {"family": "Monteleone", "given": "Erminio", "initials": "E"}, {"family": "Nunez-Parra", "given": "Alexia", "initials": "A"}, {"family": "Abdulrahman", "given": "Olagunju", "initials": "O"}, {"family": "Ritchie", "given": "Marina", "initials": "M"}, {"family": "Thomas-Danguin", "given": "Thierry", "initials": "T"}, {"family": "Walsh-Messinger", "given": "Julie", "initials": "J"}, {"family": "Al Abri", "given": "Rashid", "initials": "R"}, {"family": "Alizadeh", "given": "Rafieh", "initials": "R"}, {"family": "Bignon", "given": "Emmanuelle", "initials": "E"}, {"family": "Cantone", "given": "Elena", "initials": "E"}, {"family": "Cecchini", "given": "Maria Paola", "initials": "MP"}, {"family": "Chen", "given": "Jingguo", "initials": "J"}, {"family": "Gu\u00e0rdia", "given": "Maria Dolors", "initials": "MD"}, {"family": "Hoover", "given": "Kara C", "initials": "KC"}, {"family": "Karni", "given": "Noam", "initials": "N"}, {"family": "Navarro", "given": "Marta", "initials": "M"}, {"family": "Nolden", "given": "Alissa A", "initials": "AA"}, {"family": "Mazal", "given": "Patricia Portillo", "initials": "PP"}, {"family": "Rowan", "given": "Nicholas R", "initials": "NR"}, {"family": "Sarabi-Jamab", "given": "Atiye", "initials": "A"}, {"family": "Archer", "given": "Nicholas S", "initials": "NS"}, {"family": "Chen", "given": "Ben", "initials": "B"}, {"family": "Di Valerio", "given": "Elizabeth A", "initials": "EA"}, {"family": "Feeney", "given": "Emma L", "initials": "EL"}, {"family": "Frasnelli", "given": "Johannes", "initials": "J"}, {"family": "Hannum", "given": "Mackenzie E", "initials": "ME"}, {"family": "Hopkins", "given": "Claire", "initials": "C"}, {"family": "Klein", "given": "Hadar", "initials": "H"}, {"family": "Mignot", "given": "Coralie", "initials": "C"}, {"family": "Mucignat", "given": "Carla", "initials": "C"}, {"family": "Ning", "given": "Yuping", "initials": "Y"}, {"family": "Ozturk", "given": "Elif E", "initials": "EE"}, {"family": "Peng", "given": "Mei", "initials": "M"}, {"family": "Saatci", "given": "Ozlem", "initials": "O"}, {"family": "Sell", "given": "Elizabeth A", "initials": "EA"}, {"family": "Yan", "given": "Carol H", "initials": "CH"}, {"family": "Alfaro", "given": "Raul", "initials": "R"}, {"family": "Cecchetto", "given": "Cinzia", "initials": "C"}, {"family": "Coureaud", "given": "G\u00e9rard", "initials": "G"}, {"family": "Herriman", "given": "Riley D", "initials": "RD"}, {"family": "Justice", "given": "Jeb M", "initials": "JM"}, {"family": "Kaushik", "given": "Pavan Kumar", "initials": "PK"}, {"family": "Koyama", "given": "Sachiko", "initials": "S"}, {"family": "Overdevest", "given": "Jonathan B", "initials": "JB"}, {"family": "Pirastu", "given": "Nicola", "initials": "N"}, {"family": "Ramirez", "given": "Vicente A", "initials": "VA"}, {"family": "Roberts", "given": "S Craig", "initials": "SC"}, {"family": "Smith", "given": "Barry C", "initials": "BC"}, {"family": "Cao", "given": "Hongyuan", "initials": "H"}, {"family": "Wang", "given": "Hong", "initials": "H"}, {"family": "Birindwa", "given": "Patrick Balungwe", "initials": "PB"}, {"family": "Baguma", "given": "Marius", "initials": "M"}, {"family": null, "given": "", "initials": ""}], "type": "journal-article", "published": "2020-12-25", "journal": {"title": "Chem Senses", "issn": "0379-864X", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1093/chemse/bjaa081", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-07T13:27:02.579Z", "modified": "2021-02-26T08:45:48.282Z"}, {"entity": "publication", "iuid": "58d80771ef804c749a527a139bb4267e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/58d80771ef804c749a527a139bb4267e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/58d80771ef804c749a527a139bb4267e"}}, "title": "Practical recommendations for the management of patients with gastroenteropancreatic and thoracic (carcinoid) neuroendocrine neoplasms in the COVID-19 era.", "authors": [{"family": "Rodriguez-Freixinos", "given": "V\u00edctor", "initials": "V"}, {"family": "Capdevila", "given": "Jaume", "initials": "J"}, {"family": "Pavel", "given": "Marianne", "initials": "M"}, {"family": "Thawer", "given": "Alia", "initials": "A"}, {"family": "Baudin", "given": "Eric", "initials": "E"}, {"family": "O'Toole", "given": "Dermot", "initials": "D"}, {"family": "Herrmann", "given": "Ken", "initials": "K"}, {"family": "Welin", "given": "Staffan", "initials": "S"}, {"family": "Grozinsky-Glasberg", "given": "Simona", "initials": "S"}, {"family": "de Herder", "given": "Wouter W", "initials": "WW"}, {"family": "Valle", "given": "Juan W", "initials": "JW"}, {"family": "Herman", "given": "Jackie", "initials": "J"}, {"family": "Kolarova", "given": "Teodora", "initials": "T"}, {"family": "Bouvier", "given": "Catherine", "initials": "C"}, {"family": "Falconi", "given": "Massimo", "initials": "M"}, {"family": "Ferone", "given": "Diego", "initials": "D"}, {"family": "Singh", "given": "Simron", "initials": "S"}], "type": "journal article", "published": "2020-12-25", "journal": {"title": "Eur J Cancer", "issn": "1879-0852", "volume": "144", "issue": null, "pages": "200-214", "issn-l": "0959-8049"}, "abstract": "Neuroendocrine neoplasms (NENs) are a heterogeneous family of uncommon tumours with challenging diagnosis, clinical management and unique needs that almost always requires a multidisciplinary approach. In the absence of guidance from the scientific literature, along with the rapidly changing data available on the effect of COVID-19, we report how 12 high-volume NEN centres of expertise in 10 countries at different stages of the evolving COVID-19 global pandemic along with members of international neuroendocrine cancer patient societies have suggested to preserve high standards of care for patients with NENs. We review the multidisciplinary management of neuroendocrine neoplasms during the COVID-19 pandemic, and we suggest potential strategies to reduce risk and aid multidisciplinary treatment decision-making. By sharing our joint experiences, we aim to generate recommendations for proceeding to other institutions facing the same challenges.", "doi": "10.1016/j.ejca.2020.11.037", "pmid": "33370645", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0959-8049(20)31374-5"}], "notes": [], "created": "2021-01-07T13:13:58.912Z", "modified": "2021-01-07T13:13:58.922Z"}, {"entity": "publication", "iuid": "52346200eaa64ea0a9b13640d47de9e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/52346200eaa64ea0a9b13640d47de9e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/52346200eaa64ea0a9b13640d47de9e2"}}, "title": "Interassociation consensus recommendations for pitch-side emergency care and personal protective equipment for elite sport during the COVID-19 pandemic.", "authors": [{"family": "Hodgson", "given": "Lisa", "initials": "L"}, {"family": "Phillips", "given": "Gemma", "initials": "G"}, {"family": "Gordon", "given": "Jonathan", "initials": "J"}, {"family": "Hanson", "given": "Jonathan", "initials": "J"}, {"family": "Maclean", "given": "John", "initials": "J"}, {"family": "Mathema", "given": "Prabhat", "initials": "P"}, {"family": "Smith", "given": "Andrew", "initials": "A"}, {"family": "Woolcock", "given": "Mark", "initials": "M"}, {"family": "Cowie", "given": "Charlotte M", "initials": "CM"}, {"family": "Kemp", "given": "Simon", "initials": "S"}, {"family": "Patterson", "given": "Michael", "initials": "M"}, {"family": "Larkin", "given": "Jo", "initials": "J"}, {"family": "Hill", "given": "Jerry", "initials": "J"}, {"family": "Rossiter", "given": "Michael", "initials": "M"}, {"family": "Elliott", "given": "Niall", "initials": "N"}, {"family": "Bennett", "given": "Pippa", "initials": "P"}, {"family": "Power", "given": "Jonathan", "initials": "J"}, {"family": "Pillay", "given": "Ari", "initials": "A"}, {"family": "Singh", "given": "Harjinder", "initials": "H"}, {"family": "Sheridan", "given": "Craig", "initials": "C"}, {"family": "Hurwood", "given": "Matthew", "initials": "M"}, {"family": "Riou", "given": "Peter", "initials": "P"}, {"family": "Bennison", "given": "Anthony", "initials": "A"}, {"family": "Chakraverty", "given": "Susan", "initials": "S"}, {"family": "Tingay", "given": "Richard", "initials": "R"}, {"family": "Higgins", "given": "Richard", "initials": "R"}, {"family": "Weiler", "given": "Richard", "initials": "R"}, {"family": "Jaques", "given": "Rod", "initials": "R"}, {"family": "Spencer", "given": "Simon", "initials": "S"}, {"family": "Carmont", "given": "Michael R", "initials": "MR"}, {"family": "Patricios", "given": "Jon", "initials": "J"}], "type": "journal article", "published": "2020-12-24", "journal": {"title": "Br J Sports Med", "issn": "1473-0480", "volume": null, "issue": null, "pages": "bjsports-2020-103226", "issn-l": null}, "abstract": "The COVID-19 pandemic has necessitated many novel responses in healthcare including sport and exercise medicine. The cessation of elite sport almost globally has had significant economic implications and resulted in pressure to resume sport in very controlled conditions. This includes protecting pitch-side medical staff and players from infection. The ongoing prevalence of SARS-CoV-2 and the desire to resume professional sport required urgent best practice guidelines to be developed so that sport could be resumed as safely as possible. This set of best practice recommendations assembles early evidence for managing SARS-CoV-2 and integrates expert opinion to provide a uniform and pragmatic approach to enhance on-field and pitch-side safety for the clinician and player. The nature of SARS-CoV-2 transmission creates new hazards during resuscitation and emergency care and procedures. Recommendations for the use and type of personal protective equipment during on-field or pitch-side emergency medical care is provided based on the clinical scenario and projected risk of viral transmission.", "doi": "10.1136/bjsports-2020-103226", "pmid": "33361278", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bjsports-2020-103226"}, {"db": "pmc", "key": "PMC7768617"}], "notes": [], "created": "2021-01-07T13:43:34.897Z", "modified": "2021-01-10T17:27:46.284Z"}, {"entity": "publication", "iuid": "3b90f2b1a6614f01a77d54eccf59c5fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b90f2b1a6614f01a77d54eccf59c5fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b90f2b1a6614f01a77d54eccf59c5fd"}}, "title": "Doctor at Your Fingertips: An Exploration of Digital Visits from Stakeholders' Perspectives.", "authors": [{"family": "Demi", "given": "Selina", "initials": "S"}, {"family": "Hilmy", "given": "Samir", "initials": "S"}, {"family": "Keller", "given": "Christina", "initials": "C"}], "type": "journal article", "published": "2020-12-24", "journal": {"title": "Life (Basel)", "issn": "2075-1729", "volume": "11", "issue": "1", "issn-l": null}, "abstract": "Technological advances and the evolution of mobile technologies enable patients to meet their doctors through their smartphones. While offering the opportunity of digital visits to patients, there are also challenges for this development. The purpose of this study is to enhance the understanding of digital visits, as perceived by experts working in telemedicine companies. To serve this purpose, the authors conducted semi-structured interviews with managers and employees in eight telemedicine companies. The analysis of the empirical data confirmed the importance of digital visits and their efficiency. The potential of digital visits is expected to increase significantly, should they make use of remote devices to transfer real-time data from patients to physicians. In such a case, digital visits are expected to cover approximately 70-75% of medical cases. However, the use of remote devices must be taken with caution and specific conditions need to be taken into account. We encourage researchers to perform research on promising technologies such as artificial intelligence and remote diagnostic devices, which could make more diagnoses and conditions possible to be treated by digital visits. This is even more important in light of the ongoing Covid-19 pandemic.", "doi": "10.3390/life11010006", "pmid": "33374106", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "life11010006"}], "notes": [], "created": "2021-01-07T12:16:55.160Z", "modified": "2021-02-26T08:46:59.920Z"}, {"entity": "publication", "iuid": "6f875a8ff1de4906add4110bf19cb5b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f875a8ff1de4906add4110bf19cb5b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f875a8ff1de4906add4110bf19cb5b3"}}, "title": "Improving Hospital Oxygen Systems for COVID-19 in Low-Resource Settings: Lessons From the Field", "authors": [{"family": "Graham", "given": "Hamish R", "initials": "HR"}, {"family": "Bagayana", "given": "Sheillah M", "initials": "SM"}, {"family": "Bakare", "given": "Ayobami A", "initials": "AA"}, {"family": "Olayo", "given": "Bernard O", "initials": "BO"}, {"family": "Peterson", "given": "Stefan S", "initials": "SS"}, {"family": "Duke", "given": "Trevor", "initials": "T"}, {"family": "Falade", "given": "Adegoke G", "initials": "AG"}], "type": "journal-article", "published": "2020-12-23", "journal": {"title": "Glob Health Sci Pract", "issn": "2169-575X", "volume": "8", "issue": "4", "pages": "858-862", "issn-l": null}, "abstract": "Oxygen therapy is an essential medicine and core component of effective hospital systems. However, many hospitals in low- and middle-income countries lack reliable oxygen access-a deficiency highlighted and exacerbated by the coronavirus disease (COVID-19) pandemic. Oxygen access can be challenged by equipment that is low quality and poorly maintained, lack of clinical and technical training and protocols, and deficiencies in local infrastructure and policy environment. We share learnings from 2 decades of oxygen systems work with hospitals in Africa and the Asia-Pacific regions, highlighting practical actions that hospitals can take to immediately expand oxygen access. These include strategies to: (1) improve pulse oximetry and oxygen use, (2) support biomedical engineers to optimize existing oxygen supplies, and (3) expand on existing oxygen systems with robust equipment and smart design. We make all our resources freely available for use and local adaptation.", "doi": "10.9745/ghsp-d-20-00224", "pmid": "33361248", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-10T17:28:22.586Z", "modified": "2021-02-26T08:45:48.299Z"}, {"entity": "publication", "iuid": "109ae59a123f4d558105cb7048e44995", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/109ae59a123f4d558105cb7048e44995.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/109ae59a123f4d558105cb7048e44995"}}, "title": "Spices to Control COVID-19 Symptoms: Yes, but Not Only\u2026.", "authors": [{"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Czarlewski", "given": "Wienczyslawa", "initials": "W"}, {"family": "Zuberbier", "given": "Torsten", "initials": "T"}, {"family": "Mullol", "given": "Joaquim", "initials": "J"}, {"family": "Blain", "given": "Hubert", "initials": "H"}, {"family": "Cristol", "given": "Jean-Paul", "initials": "JP"}, {"family": "De La Torre", "given": "Rafael", "initials": "R"}, {"family": "Le Moing", "given": "Vincent", "initials": "V"}, {"family": "Pizarro Lozano", "given": "Nieves", "initials": "N"}, {"family": "Bedbrook", "given": "Anna", "initials": "A"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Akdis", "given": "Cezmi A", "initials": "CA"}, {"family": "Canonica", "given": "G Walter", "initials": "GW"}, {"family": "Cruz", "given": "Alvaro A", "initials": "AA"}, {"family": "Fiocchi", "given": "Alessandro", "initials": "A"}, {"family": "Fonseca", "given": "Joao A", "initials": "JA"}, {"family": "Fonseca", "given": "Susana", "initials": "S"}, {"family": "Gemicio\u011flu", "given": "Bilun", "initials": "B"}, {"family": "Haahtela", "given": "Tari", "initials": "T"}, {"family": "Iaccarino", "given": "Guido", "initials": "G"}, {"family": "Ivancevich", "given": "Juan Carlos", "initials": "JC"}, {"family": "Jutel", "given": "Marek", "initials": "M"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Kuna", "given": "Piotr", "initials": "P"}, {"family": "Larenas-Linnemann", "given": "D\u00e9sir\u00e9e E", "initials": "DE"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Okamoto", "given": "Yoshitaka", "initials": "Y"}, {"family": "Papadopoulos", "given": "Nikolaos G", "initials": "NG"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Reynes", "given": "Jacques", "initials": "J"}, {"family": "Rolland", "given": "Yves", "initials": "Y"}, {"family": "Rouadi", "given": "Philip W", "initials": "PW"}, {"family": "Samolinski", "given": "Boleslaw", "initials": "B"}, {"family": "Sheikh", "given": "Aziz", "initials": "A"}, {"family": "Toppila-Salmi", "given": "Sanna", "initials": "S"}, {"family": "Valiulis", "given": "Arunas", "initials": "A"}, {"family": "Choi", "given": "Hak-Jong", "initials": "HJ"}, {"family": "Kim", "given": "Hyun Ju", "initials": "HJ"}, {"family": "Anto", "given": "Josep M", "initials": "JM"}], "type": "journal article", "published": "2020-12-22", "journal": {"title": "Int Arch Allergy Immunol", "issn": "1018-2438", "volume": "182", "issue": "6", "pages": "489-495", "issn-l": null}, "abstract": "There are large country variations in COVID-19 death rates that may be partly explained by diet. Many countries with low COVID-19 death rates have a common feature of eating large quantities of fermented vegetables such as cabbage and, in some continents, various spices. Fermented vegetables and spices are agonists of the antioxidant transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and spices are transient receptor potential ankyrin 1 and vanillin 1 (TRPA1/V1) agonists. These mechanisms may explain many COVID-19 symptoms and severity. It appears that there is a synergy between Nrf2 and TRPA1/V1 foods that may explain the role of diet in COVID-19. One of the mechanisms of COVID-19 appears to be an oxygen species (ROS)-mediated process in synergy with TRP channels, modulated by Nrf2 pathways. Spicy foods are likely to desensitize TRP channels and act in synergy with exogenous antioxidants that activate the Nrf2 pathway.", "doi": "10.1159/000513538", "pmid": "33352565", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "000513538"}, {"db": "pmc", "key": "PMC7900475"}], "notes": [], "created": "2021-01-08T08:23:27.711Z", "modified": "2021-07-14T07:52:46.595Z"}, {"entity": "publication", "iuid": "61cc72674c1b4238a17acd0e8258e2fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61cc72674c1b4238a17acd0e8258e2fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61cc72674c1b4238a17acd0e8258e2fd"}}, "title": "Sex and age differences in COVID-19 mortality in Europe", "authors": [{"family": "Ahrenfeldt", "given": "Linda Juel", "initials": "LJ"}, {"family": "Otavova", "given": "Martina", "initials": "M"}, {"family": "Christensen", "given": "Kaare", "initials": "K"}, {"family": "Lindahl-Jacobsen", "given": "Rune", "initials": "R"}], "type": "journal-article", "published": "2020-12-22", "journal": {"title": "Wien Klin Wochenschr", "issn": "0043-5325", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1007/s00508-020-01793-9", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-10T17:35:36.357Z", "modified": "2021-02-26T08:46:59.983Z"}, {"entity": "publication", "iuid": "e1e465b949a64f3ab9edb94f803cc998", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e1e465b949a64f3ab9edb94f803cc998.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e1e465b949a64f3ab9edb94f803cc998"}}, "title": "Potentially Prolonged Psychological Distress from Postponed Olympic and Paralympic Games during COVID-19-Career Uncertainty in Elite Athletes.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "Moesch", "given": "Karin", "initials": "K"}, {"family": "J\u00f6nsson", "given": "Caroline", "initials": "C"}, {"family": "Kentt\u00e4", "given": "G\u00f6ran", "initials": "G"}], "type": "journal article", "published": "2020-12-22", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "1", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on the world of sports due to periods of home quarantine, bans against public gatherings, travel restrictions, and a large number of postponed or canceled major sporting events. The literature hitherto is sparse, but early indications display signs of psychological impact on elite athletes due to the pandemic. However, beyond acute effects from lockdown and short-term interrupted athletic seasons, the postponed and still uncertain Olympic and Paralympic Games may represent a major career insecurity to many athletes world-wide, and may lead to severe changes to everyday lives and potentially prolonged psychological distress. Given the long-term perspective of these changes, researchers and stakeholders should address mental health and long-term job insecurity in athletes, including a specific focus on those with small financial margins, such as many female athletes, parasports athletes, athletes in smaller sports, and athletes from developing countries. Implications and the need for research are discussed.", "doi": "10.3390/ijerph18010002", "pmid": "33374935", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph18010002"}], "notes": [], "created": "2021-01-07T12:14:31.841Z", "modified": "2021-02-26T08:47:00.247Z"}, {"entity": "publication", "iuid": "a99f54c3366840b9b773368a79f5ae97", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a99f54c3366840b9b773368a79f5ae97.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a99f54c3366840b9b773368a79f5ae97"}}, "title": "Modelling the effect of the COVID-19 pandemic on violent discipline against children.", "authors": [{"family": "Fabbri", "given": "Camilla", "initials": "C"}, {"family": "Bhatia", "given": "Amiya", "initials": "A"}, {"family": "Petzold", "given": "Max", "initials": "M"}, {"family": "Jugder", "given": "Munkhbadar", "initials": "M"}, {"family": "Guedes", "given": "Alessandra", "initials": "A"}, {"family": "Cappa", "given": "Claudia", "initials": "C"}, {"family": "Devries", "given": "Karen", "initials": "K"}], "type": "journal article", "published": "2020-12-22", "journal": {"title": "Child Abuse Negl", "issn": "1873-7757", "volume": null, "issue": null, "pages": "104897", "issn-l": null}, "abstract": "The COVID-19 pandemic could increase violence against children at home. However, collecting empirical data on violence is challenging due to ethical, safety, and data quality concerns.\n\nThis study estimated the anticipated effect of COVID-19 on violent discipline at home using multivariable predictive regression models.\n\nChildren aged 1-14 years and household members from the Multiple Indicator Cluster Surveys (MICS) conducted in Nigeria, Mongolia, and Suriname before the COVID-19 pandemic were included.\n\nA conceptual model of how the COVID-19 pandemic could affect risk factors for violent discipline was developed. Country specific multivariable linear models were used to estimate the association between selected variables from MICS and a violent discipline score which captured the average combination of violent disciplinary methods used in the home. A review of the literature informed the development of quantitative assumptions about how COVID-19 would impact the selected variables under a \"high restrictions\" pandemic scenario, approximating conditions expected during a period of intense response measures, and a \"lower restrictions\" scenario with easing of COVID-19 restrictions but with sustained economic impacts. These assumptions were used to estimate changes in violent discipline scores.\n\nUnder a \"high restrictions\" scenario there would be a 35%-46% increase in violent discipline scores in Nigeria, Mongolia and Suriname, and under a \"lower restrictions\" scenario there would be between a 4%-6% increase in violent discipline scores in these countries.\n\nPolicy makers need to plan for increases in violent discipline during successive waves of lockdowns.", "doi": "10.1016/j.chiabu.2020.104897", "pmid": "33451678", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0145-2134(20)30552-4"}], "notes": [], "created": "2021-01-18T14:37:30.758Z", "modified": "2021-02-26T08:47:00.147Z"}, {"entity": "publication", "iuid": "8da68cb7dd1e494f9d694277f8730a4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8da68cb7dd1e494f9d694277f8730a4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8da68cb7dd1e494f9d694277f8730a4c"}}, "title": "Implications and Limitations of Social Distancing Strategies (SDS) to Mitigate the Impact of the COVID-19 Pandemic.", "authors": [{"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}, {"family": "Burkle", "given": "Frederick M", "initials": "FM"}, {"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}], "type": "journal article", "published": "2020-12-22", "journal": {"title": "Disaster Med Public Health Prep", "issn": "1938-744X", "volume": null, "issue": null, "pages": "1-2", "issn-l": "1935-7893"}, "abstract": null, "doi": "10.1017/dmp.2020.500", "pmid": "33769241", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1935789320005005"}], "notes": [], "created": "2021-03-29T09:26:41.822Z", "modified": "2021-03-29T09:26:41.833Z"}, {"entity": "publication", "iuid": "7029db400dfd4e1592553190873fbe5b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7029db400dfd4e1592553190873fbe5b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7029db400dfd4e1592553190873fbe5b"}}, "title": "Development and external validation of a logistic regression derived formula based on repeated routine hematological measurements predicting survival of hospitalized Covid-19 patients", "authors": [{"family": "Heber", "given": "Stefan", "initials": "S"}, {"family": "Pereyra", "given": "David", "initials": "D"}, {"family": "Schrottmaier", "given": "Waltraud C", "initials": "WC"}, {"family": "Kammerer", "given": "Kerstin", "initials": "K"}, {"family": "Santol", "given": "Jonas", "initials": "J"}, {"family": "Pawelka", "given": "Erich", "initials": "E"}, {"family": "Hana", "given": "Markus", "initials": "M"}, {"family": "Scholz", "given": "Alexander", "initials": "A"}, {"family": "Liu", "given": "Markus", "initials": "M"}, {"family": "Hell", "given": "Agnes", "initials": "A"}, {"family": "Heiplik", "given": "Klara", "initials": "K"}, {"family": "Lickefett", "given": "Benno", "initials": "B"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Traugott", "given": "Marianna T", "initials": "MT"}, {"family": "Neub\u00f6ck", "given": "Matthias", "initials": "M"}, {"family": "Sch\u00f6rgenhofer", "given": "Christian", "initials": "C"}, {"family": "Seitz", "given": "Tamara", "initials": "T"}, {"family": "Firbas", "given": "Christa", "initials": "C"}, {"family": "Karolyi", "given": "Mario", "initials": "M"}, {"family": "Weiss", "given": "G\u00fcnter", "initials": "G"}, {"family": "Jilma", "given": "Bernd", "initials": "B"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Bellmann-Weiler", "given": "Rosa", "initials": "R"}, {"family": "Salzer", "given": "Helmut J F", "initials": "HJF"}, {"family": "Fischer", "given": "Michael J M", "initials": "MJM"}, {"family": "Zoufaly", "given": "Alexander", "initials": "A"}, {"family": "Assinger", "given": "Alice", "initials": "A"}], "type": "posted-content", "published": "2020-12-22", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.20.20248563", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-04T08:54:38.303Z", "modified": "2021-02-26T08:46:13.223Z"}, {"entity": "publication", "iuid": "d22a5c0867e647ceb971ab628b8454eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d22a5c0867e647ceb971ab628b8454eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d22a5c0867e647ceb971ab628b8454eb"}}, "title": "COVID-19 and the Swedish enigma.", "authors": [{"family": "Claeson", "given": "Mariam", "initials": "M"}, {"family": "Hanson", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2020-12-22", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": null, "issue": null, "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)32750-1", "pmid": "33357494", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)32750-1"}, {"db": "pmc", "key": "PMC7755568"}], "notes": [], "created": "2021-01-08T08:19:51.738Z", "modified": "2021-01-10T17:30:11.876Z"}, {"entity": "publication", "iuid": "e5fe6d45987442a8ac2cf0c4068949e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e5fe6d45987442a8ac2cf0c4068949e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e5fe6d45987442a8ac2cf0c4068949e7"}}, "title": "Impact of simulation-based teamwork training on COVID-19 distress in healthcare professionals.", "authors": [{"family": "Beneria", "given": "Anna", "initials": "A"}, {"family": "Arnedo", "given": "Mireia", "initials": "M"}, {"family": "Contreras", "given": "Sofia", "initials": "S"}, {"family": "P\u00e9rez-Carrasco", "given": "Marco", "initials": "M"}, {"family": "Garcia-Ruiz", "given": "Itziar", "initials": "I"}, {"family": "Rodr\u00edguez-Carballeira", "given": "M\u00f3nica", "initials": "M"}, {"family": "Radu\u00e0", "given": "Joaquim", "initials": "J"}, {"family": "Rius", "given": "Jordi Ba\u00f1eras", "initials": "JB"}], "type": "journal article", "published": "2020-12-21", "journal": {"title": "BMC Med Educ", "issn": "1472-6920", "volume": "20", "issue": "1", "pages": "515", "issn-l": null}, "abstract": "Non-technical skills such as leadership, communication, or situation awareness should lead to effective teamwork in a crisis. This study aimed to analyse the role of these skills in the emotional response of health professionals to the COVID-19 pandemic.\n\nBefore the COVID-19 outbreak, 48 doctors and 48 nurses participated in a simulation-based teamwork training program based on teaching non-technical skills through simulation. In May 2020, this group of professionals from a COVID-19 referral hospital was invited to participate in a survey exploring stress, anxiety, and depression, using the PSS-14 (Perceived Stress Scale) and the HADS (Hospital Anxiety and Depression Scale) measures. A control group that did not receive the training was included. We conducted a logistic regression to assess whether having attended a simulation-based teamwork training program modified the probability of presenting psychological distress (PSS-14 > 18 or HADS> 12).\n\nA total of 141 healthcare professionals were included, 77 in the intervention group and 64 in the control group. Based on the PSS-14, 70.1% of the intervention group and 75% of the control group (p = 0.342) had symptoms of stress. Having contact with COVID-19 patients [OR 4.16(1.64-10.52)]; having minors in charge [OR 2.75 (1.15-6.53)]; working as a doctor [0.39(0.16-0.95)], and being a woman [OR 2.94(1.09-7.91)] were related with PSS14 symptoms. Based on the HADS, 54.6% of the intervention group and 42.2% of the control group (p = 0.346) had symptoms of anxiety or depression. Having contact with COVID-19 patients [OR 2.17(1.05-4.48)] and having minors in charge [OR 2.14(1.06-4.32)] were related to HADS symptoms. Healthcare professionals who attended COVID-19 patients showed higher levels of anxiety and depression [OR 2.56(1.03-6.36) (p = 0.043)].\n\nHealthcare professionals trained in non-technical skills through simulation tended towards higher levels of anxiety and depression and fewer levels of stress, during the COVID-19 pandemic.", "doi": "10.1186/s12909-020-02427-4", "pmid": "33349248", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12909-020-02427-4"}, {"db": "pmc", "key": "PMC7751744"}, {"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-08T08:24:47.491Z", "modified": "2021-02-26T08:47:00.263Z"}, {"entity": "publication", "iuid": "d9ea5ba12df64dcf9f67088c9302d0ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d9ea5ba12df64dcf9f67088c9302d0ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d9ea5ba12df64dcf9f67088c9302d0ee"}}, "title": "Covid-19 intensive care admissions and mortality among swedish patients with cancer.", "authors": [{"family": "Larfors", "given": "Gunnar", "initials": "G"}, {"family": "Pahnke", "given": "Simon", "initials": "S"}, {"family": "State", "given": "Maria", "initials": "M"}, {"family": "Fredriksson", "given": "Katarina", "initials": "K"}, {"family": "Pettersson", "given": "David", "initials": "D"}], "type": "letter", "published": "2020-12-21", "journal": {"title": "Acta Oncol", "issn": "1651-226X", "volume": null, "issue": null, "pages": "1-3", "issn-l": null}, "abstract": null, "doi": "10.1080/0284186X.2020.1854481", "pmid": "33345664", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-07T13:30:27.979Z", "modified": "2021-02-26T08:45:48.781Z"}, {"entity": "publication", "iuid": "be488f3e4f824c5a83f9ad103c1b7a5d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be488f3e4f824c5a83f9ad103c1b7a5d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be488f3e4f824c5a83f9ad103c1b7a5d"}}, "title": "Mental health among pregnant women during the pandemic in Sweden\u2013 a mixed methods approach using data from the Mom2B mobile application for research", "authors": [{"family": "Fransson", "given": "Emma", "initials": "E", "orcid": "0000-0001-9010-8522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c3926adfe6e74e91b084e1e5531af80e.json"}}, {"family": "Karalexi", "given": "Maria", "initials": "M"}, {"family": "Kimmel", "given": "Mary", "initials": "M", "orcid": "0000-0002-6270-5394", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/55a598795f8f4202a6006ba71081d0d0.json"}}, {"family": "Br\u00e4nn", "given": "Emma", "initials": "E", "orcid": "0000-0001-9664-7973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3add26b456fd4ce0ad3e649aa7aa4dff.json"}}, {"family": "Kollia", "given": "Natasa", "initials": "N", "orcid": "0000-0001-7868-3524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6bbd460a1869481b9dcbf80263ef27e5.json"}}, {"family": "van Zoest", "given": "Vera", "initials": "V", "orcid": "0000-0002-3017-0874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72aee535dc8c45478a4cf678e01d2421.json"}}, {"family": "Nordling", "given": "Eira", "initials": "E"}, {"family": "Papadopoulos", "given": "Fotios C", "initials": "FC", "orcid": "0000-0002-8692-3652", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a12a16c269b479f81b6f8306185cada.json"}}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A", "orcid": "0000-0002-4935-7532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76c46ccb0ade4acaa7b53f3fd4240683.json"}}], "type": "posted-content", "published": "2020-12-20", "journal": {"title": "", "issn": null, "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1101/2020.12.18.20248466", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-10T04:11:26.328Z", "modified": "2021-06-14T06:39:03.115Z"}, {"entity": "publication", "iuid": "8cf9f12e77c94c808fc63cfc8aadd3b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8cf9f12e77c94c808fc63cfc8aadd3b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8cf9f12e77c94c808fc63cfc8aadd3b4"}}, "title": "Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale", "authors": [{"family": "Paramasivam", "given": "Prasath", "initials": "P"}, {"family": "Franke", "given": "Christian", "initials": "C"}, {"family": "St\u00f6ter", "given": "Martin", "initials": "M"}, {"family": "H\u00f6ijer", "given": "Andreas", "initials": "A"}, {"family": "Bartesaghi", "given": "Stefano", "initials": "S"}, {"family": "Sabirsh", "given": "Alan", "initials": "A"}, {"family": "Lindfors", "given": "Lennart", "initials": "L"}, {"family": "Yanez Arteta", "given": "Marianna", "initials": "M"}, {"family": "Dahl\u00e9n", "given": "Anders", "initials": "A"}, {"family": "Bak", "given": "Annette", "initials": "A"}, {"family": "Andersson", "given": "Shalini", "initials": "S"}, {"family": "Kalaidzidis", "given": "Yannis", "initials": "Y"}, {"family": "Bickle", "given": "Marc", "initials": "M"}, {"family": "Zerial", "given": "Marino", "initials": "M"}], "type": "posted-content", "published": "2020-12-20", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.18.423541", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-15T15:56:01.936Z", "modified": "2021-02-26T08:45:48.453Z"}, {"entity": "publication", "iuid": "7b1c5fe3808e43868029cd853560c02a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b1c5fe3808e43868029cd853560c02a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b1c5fe3808e43868029cd853560c02a"}}, "title": "Considerations for scuba and breath-hold divers during the COVID-19 pandemic: A call for awareness.", "authors": [{"family": "Elia", "given": "Antonis", "initials": "A"}, {"family": "Gennser", "given": "Mikael", "initials": "M"}], "type": "journal article", "published": "2020-12-20", "journal": {"title": "Diving Hyperb Med", "issn": "1833-3516", "volume": "50", "issue": "4", "pages": "413-416", "issn-l": null}, "abstract": "In late 2019, a highly pathogenic novel coronavirus (CoV), severe acute respiratory syndrome (SARS)-CoV-2 emerged from Wuhan, China and led to a global pandemic. SARS-CoV-2 has a predilection for the pulmonary system and can result in serious pneumonia necessitating hospitalisation. Computed tomography (CT) chest scans of patients with severe symptoms, show signs of multifocal bilateral ground or ground-glass opacities (GGO) associated with consolidation areas with patchy distribution. However, it is less well known that both asymptomatic and mild symptomatic patients may exhibit similar lung changes. Presumably, the various pathological changes in the lungs may increase the risk of adverse events during diving (e.g., lung barotrauma, pulmonary oedema, etc.), thus these lung manifestations need to be considered prior to allowing resumption of diving. Presently, it is not known how the structural changes in the lungs develop and to what extent they resolve, in particular in asymptomatic carriers and patients with mild disease. However, current evidence indicates that a month of recovery may be too short an interval to guarantee complete pulmonary restitution even after COVID-19 infections not demanding hospital care.", "doi": "10.28920/dhm50.4.413-416", "pmid": "33325024", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-21T10:00:27.634Z", "modified": "2021-01-10T18:14:36.428Z"}, {"entity": "publication", "iuid": "5896670bf8704d568137c3fb607add22", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5896670bf8704d568137c3fb607add22.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5896670bf8704d568137c3fb607add22"}}, "title": "Effects on Gambling Activity From Coronavirus Disease 2019-An Analysis of Revenue-Based Taxation of Online- and Land-Based Gambling Operators During the Pandemic.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-12-17", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "11", "issue": null, "pages": "611939", "issn-l": "1664-0640"}, "abstract": "Background: Concerns have been raised about increased gambling problems during the coronavirus disease (COVID-19) crisis, particularly in settings with high online gambling and risks of migration from land-based to riskier online-based gambling types. However, few non-self-reported data sources are hitherto available. The present study aimed to assess changes in the online- and land-based gambling markets in Sweden during the first months affected by the societal impact of COVID-19. Methods: Data were derived from national authority data describing monthly taxations of all licensed Swedish gambling operators, whose monthly tax payments are directly based on gambling revenue. Subdivisions of the gambling market were followed monthly from before COVID-19 onset in Sweden (mainly February 2020) through June 2020, when the sports market was restarted after COVID-19 lockdown. Results: Overall revenue-based taxations in the licensed gambling decreased markedly from February to March, but stabilized onto an overall modest decrease through June. Commercial online casino/betting, despite some decrease in March, was maintained on a relatively stable level through June. However, within this category, horse betting increased steeply during the pandemic but returned to prepandemic levels later during the period. The state-owned operator in betting/online casino decreased markedly throughout the pandemic. The remaining commercial operators, mainly in online casino and online betting, demonstrated no change during the pandemic and ended on a June level 14% above the February level. Throughout the pandemic, the smaller restaurant casinos decreased markedly, while major state-owned casinos also closed entirely. State-owned lotteries and electronic gambling machines decreased markedly but were rapidly normalized to prepandemic levels. Conclusions: Commercial online gambling operators' revenues remained stable throughout the pandemic, despite the dramatic lockdown in sports. Thus, chance-based online games may have remained a strong actor in the gambling market despite the COVID-19 crisis, in line with previous self-report data. A sudden increase in horse betting during the sports lockdown and its decrease when sports reopened confirm the picture of possible COVID-19-related migration between gambling types, indicating a volatility with potential impact on gambling-related public health.", "doi": "10.3389/fpsyt.2020.611939", "pmid": "33391059", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7773659"}], "notes": [], "created": "2021-01-05T15:18:01.702Z", "modified": "2021-02-26T08:46:59.964Z"}, {"entity": "publication", "iuid": "02b49bae4e8c42dcaecb844185a7ae94", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02b49bae4e8c42dcaecb844185a7ae94.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02b49bae4e8c42dcaecb844185a7ae94"}}, "title": "Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy.", "authors": [{"family": "Wacker", "given": "Anna", "initials": "A"}, {"family": "Weigand", "given": "Julia E", "initials": "JE", "orcid": "0000-0003-4247-1348", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5229ec08ce9242c19049804ff8a77085.json"}}, {"family": "Akabayov", "given": "Sabine R", "initials": "SR"}, {"family": "Altincekic", "given": "Nadide", "initials": "N"}, {"family": "Bains", "given": "Jasleen Kaur", "initials": "JK"}, {"family": "Banijamali", "given": "Elnaz", "initials": "E"}, {"family": "Binas", "given": "Oliver", "initials": "O"}, {"family": "Castillo-Martinez", "given": "Jesus", "initials": "J"}, {"family": "Cetiner", "given": "Erhan", "initials": "E"}, {"family": "Ceylan", "given": "Bet\u00fcl", "initials": "B"}, {"family": "Chiu", "given": "Liang-Yuan", "initials": "LY"}, {"family": "Davila-Calderon", "given": "Jesse", "initials": "J"}, {"family": "Dhamotharan", "given": "Karthikeyan", "initials": "K"}, {"family": "Duchardt-Ferner", "given": "Elke", "initials": "E"}, {"family": "Ferner", "given": "Jan", "initials": "J"}, {"family": "Frydman", "given": "Lucio", "initials": "L"}, {"family": "F\u00fcrtig", "given": "Boris", "initials": "B", "orcid": "0000-0001-6443-7656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5e0849167334290a5bd6691644783bf.json"}}, {"family": "Gallego", "given": "Jos\u00e9", "initials": "J", "orcid": "0000-0002-0627-6927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b188371610a46858542181b11863966.json"}}, {"family": "Gr\u00fcn", "given": "J Tassilo", "initials": "JT"}, {"family": "Hacker", "given": "Carolin", "initials": "C"}, {"family": "Haddad", "given": "Christina", "initials": "C"}, {"family": "H\u00e4hnke", "given": "Martin", "initials": "M"}, {"family": "Hengesbach", "given": "Martin", "initials": "M", "orcid": "0000-0001-9414-1602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa75083441294b4f8fe68b1a42fee601.json"}}, {"family": "Hiller", "given": "Fabian", "initials": "F"}, {"family": "Hohmann", "given": "Katharina F", "initials": "KF"}, {"family": "Hymon", "given": "Daniel", "initials": "D"}, {"family": "de Jesus", "given": "Vanessa", "initials": "V"}, {"family": "Jonker", "given": "Henry", "initials": "H"}, {"family": "Keller", "given": "Heiko", "initials": "H"}, {"family": "Knezic", "given": "Bozana", "initials": "B"}, {"family": "Landgraf", "given": "Tom", "initials": "T"}, {"family": "L\u00f6hr", "given": "Frank", "initials": "F"}, {"family": "Luo", "given": "Le", "initials": "L"}, {"family": "Mertinkus", "given": "Klara R", "initials": "KR"}, {"family": "Muhs", "given": "Christina", "initials": "C"}, {"family": "Novakovic", "given": "Mihajlo", "initials": "M"}, {"family": "Oxenfarth", "given": "Andreas", "initials": "A"}, {"family": "Palomino-Sch\u00e4tzlein", "given": "Martina", "initials": "M"}, {"family": "Petzold", "given": "Katja", "initials": "K"}, {"family": "Peter", "given": "Stephen A", "initials": "SA"}, {"family": "Pyper", "given": "Dennis J", "initials": "DJ"}, {"family": "Qureshi", "given": "Nusrat S", "initials": "NS"}, {"family": "Riad", "given": "Magdalena", "initials": "M"}, {"family": "Richter", "given": "Christian", "initials": "C"}, {"family": "Saxena", "given": "Krishna", "initials": "K"}, {"family": "Schamber", "given": "Tatjana", "initials": "T"}, {"family": "Scherf", "given": "Tali", "initials": "T"}, {"family": "Schlagnitweit", "given": "Judith", "initials": "J"}, {"family": "Schlundt", "given": "Andreas", "initials": "A", "orcid": "0000-0003-2254-7560", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/662b48aa496e4109aab02871f6b1d43d.json"}}, {"family": "Schnieders", "given": "Robbin", "initials": "R"}, {"family": "Schwalbe", "given": "Harald", "initials": "H", "orcid": "0000-0001-5693-7909", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32641f04b8504ac493d46947e87e4f59.json"}}, {"family": "Simba-Lahuasi", "given": "Alvaro", "initials": "A"}, {"family": "Sreeramulu", "given": "Sridhar", "initials": "S"}, {"family": "Stirnal", "given": "Elke", "initials": "E"}, {"family": "Sudakov", "given": "Alexey", "initials": "A"}, {"family": "Tants", "given": "Jan-Niklas", "initials": "JN"}, {"family": "Tolbert", "given": "Blanton S", "initials": "BS"}, {"family": "V\u00f6gele", "given": "Jennifer", "initials": "J"}, {"family": "Wei\u00df", "given": "Lena", "initials": "L"}, {"family": "Wirmer-Bartoschek", "given": "Julia", "initials": "J"}, {"family": "Wirtz Martin", "given": "Maria A", "initials": "MA"}, {"family": "W\u00f6hnert", "given": "Jens", "initials": "J", "orcid": "0000-0001-7193-401X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/611eebfc08f54e20b4dc9b881da010b8.json"}}, {"family": "Zetzsche", "given": "Heidi", "initials": "H"}], "type": "journal article", "published": "2020-12-16", "journal": {"title": "Nucleic Acids Res", "issn": "1362-4962", "volume": "48", "issue": "22", "pages": "12415-12435", "issn-l": "0305-1048"}, "abstract": "The current pandemic situation caused by the Betacoronavirus SARS-CoV-2 (SCoV2) highlights the need for coordinated research to combat COVID-19. A particularly important aspect is the development of medication. In addition to viral proteins, structured RNA elements represent a potent alternative as drug targets. The search for drugs that target RNA requires their high-resolution structural characterization. Using nuclear magnetic resonance (NMR) spectroscopy, a worldwide consortium of NMR researchers aims to characterize potential RNA drug targets of SCoV2. Here, we report the characterization of 15 conserved RNA elements located at the 5' end, the ribosomal frameshift segment and the 3'-untranslated region (3'-UTR) of the SCoV2 genome, their large-scale production and NMR-based secondary structure determination. The NMR data are corroborated with secondary structure probing by DMS footprinting experiments. The close agreement of NMR secondary structure determination of isolated RNA elements with DMS footprinting and NMR performed on larger RNA regions shows that the secondary structure elements fold independently. The NMR data reported here provide the basis for NMR investigations of RNA function, RNA interactions with viral and host proteins and screening campaigns to identify potential RNA binders for pharmaceutical intervention.", "doi": "10.1093/nar/gkaa1013", "pmid": "33167030", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7736788"}, {"db": "pii", "key": "5961789"}], "notes": [], "created": "2020-11-27T10:04:35.267Z", "modified": "2023-06-19T15:30:37.089Z"}, {"entity": "publication", "iuid": "343607ba24654e4c81bcf4e66035a688", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/343607ba24654e4c81bcf4e66035a688.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/343607ba24654e4c81bcf4e66035a688"}}, "title": "Large differences in community COVID-19 testing across geographic areas in a Swedish region with 385,000 inhabitants", "authors": [{"family": "Kennedy", "given": "Beatrice", "initials": "B"}, {"family": "Martinell", "given": "Mats", "initials": "M"}, {"family": "Hammar", "given": "Ulf", "initials": "U"}, {"family": "van Zoest", "given": "Vera", "initials": "V"}, {"family": "Kristiansson", "given": "Robert S", "initials": "RS"}, {"family": "Fitipaldi", "given": "Hugo", "initials": "H"}, {"family": "Tsereteli", "given": "Neli", "initials": "N"}, {"family": "Varotsis", "given": "Georgios", "initials": "G"}, {"family": "Dekkers", "given": "Koen", "initials": "K"}, {"family": "Bjork", "given": "Jonas", "initials": "J"}, {"family": "Fall", "given": "Tove", "initials": "T"}], "type": "posted-content", "published": "2020-12-16", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.15.20248247", "pmid": null, "labels": {"Type: Preprint": null, "Funder: Vinnova": null, "Category: Public Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-12-18T07:46:23.709Z", "modified": "2021-02-26T08:46:59.897Z"}, {"entity": "publication", "iuid": "2c67476bc4a941ec8ef786c921115f6a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c67476bc4a941ec8ef786c921115f6a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c67476bc4a941ec8ef786c921115f6a"}}, "title": "Effects of Dapagliflozin on Prevention of Major Clinical Events and Recovery in Patients with Respiratory Failure due to COVID-19: The Design and Rationale for the DARE-19 study.", "authors": [{"family": "Kosiborod", "given": "Mikhail", "initials": "M"}, {"family": "Berwanger", "given": "Otavio", "initials": "O"}, {"family": "Koch", "given": "Gary G", "initials": "GG"}, {"family": "Martinez", "given": "Felipe", "initials": "F"}, {"family": "Mukhtar", "given": "Omar", "initials": "O"}, {"family": "Verma", "given": "Subodh", "initials": "S"}, {"family": "Chopra", "given": "Vijay", "initials": "V"}, {"family": "Javaheri", "given": "Ali", "initials": "A"}, {"family": "Ambery", "given": "Philip", "initials": "P"}, {"family": "Gasparyan", "given": "Samvel B", "initials": "SB"}, {"family": "Buenconsejo", "given": "Joan", "initials": "J"}, {"family": "Sj\u00f6str\u00f6m", "given": "C David", "initials": "CD"}, {"family": "Langkilde", "given": "Anna Maria", "initials": "AM"}, {"family": "Oscarsson", "given": "Jan", "initials": "J"}, {"family": "Esterline", "given": "Russell", "initials": "R"}], "type": "journal article", "published": "2020-12-15", "journal": {"title": "Diabetes Obes Metab", "issn": "1463-1326", "issn-l": null, "volume": "23", "issue": "4", "pages": "886-896"}, "abstract": "Coronavirus disease 2019 (COVID-19) is caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It can lead to multiorgan failure, including respiratory and cardiovascular decompensation, and kidney injury, with significant associated morbidity and mortality, particularly in patients with underlying metabolic, cardiovascular, respiratory, or kidney disease. Dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, has shown significant cardio- and renoprotective benefits in patients with type 2 diabetes (with and without atherosclerotic cardiovascular disease), heart failure, and chronic kidney disease, and may provide similar organ protection in high-risk patients with COVID-19.\r\n\r\nDARE-19 (NCT04350593) is an investigator-initiated, collaborative, international, multicenter, randomized, double-blind, placebo-controlled study testing the dual hypotheses that dapagliflozin can reduce the incidence of cardiovascular, kidney and/or respiratory complications or all-cause mortality, or improve clinical recovery, in adult patients hospitalized with COVID-19 but not critically ill on admission. Eligible patients will have \u22651 cardiometabolic risk factor for COVID-19 complications. Patients will be randomized 1:1 to dapagliflozin 10 mg or placebo. Primary efficacy endpoints are time to development of new or worsened organ dysfunction during index hospitalization, or all-cause mortality, and the hierarchical composite endpoint of change in clinical status through Day 30 of treatment. Safety of dapagliflozin in individuals with COVID-19 will be assessed.\r\n\r\nDARE-19 will evaluate whether dapagliflozin can prevent COVID-19-related complications and all-cause mortality, or improve clinical recovery, and assess dapagliflozin's safety profile in this patient population. Currently, DARE-19 is the first large randomized controlled trial investigating use of SGLT2 inhibitors in patients with COVID-19. This article is protected by copyright. All rights reserved.", "doi": "10.1111/dom.14296", "pmid": "33319454", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-21T10:06:26.130Z", "modified": "2021-04-10T09:47:17.457Z"}, {"entity": "publication", "iuid": "a51a373837da48a78fb9bb0ed8a526c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a51a373837da48a78fb9bb0ed8a526c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a51a373837da48a78fb9bb0ed8a526c9"}}, "title": "COVID-19 Highlights the Need for Inclusive Responses to Public Health Emergencies in Africa.", "authors": [{"family": "Adebisi", "given": "Yusuff Adebayo", "initials": "YA"}, {"family": "Ekpenyong", "given": "Aniekan", "initials": "A"}, {"family": "Ntacyabukura", "given": "Blaise", "initials": "B"}, {"family": "Lowe", "given": "Mat", "initials": "M"}, {"family": "Jimoh", "given": "Nafisat Dasola", "initials": "ND"}, {"family": "Abdulkareem", "given": "Toyyib Oladimeji", "initials": "TO"}, {"family": "Lucero-Prisno", "given": "Don Eliseo", "initials": "DE"}], "type": "journal article", "published": "2020-12-15", "journal": {"title": "Am J Trop Med Hyg", "issn": "1476-1645", "volume": null, "issue": null, "issn-l": "0002-9637"}, "abstract": "COVID-19 is a global public health emergency affecting many countries around the world. Although African governments and other stakeholders are making efforts to contain the pandemic, the outbreak continues to impact human rights and exacerbates inequalities and disparities that are already in existence. The concept of inclusive health focuses on good health and well-being for everyone, and this entails health services that are equitable, affordable, and efficacious. Creating equitable access to mainstream health and healthcare services and ensuring inclusive health responses remain a means of addressing health inequities and disparities. In this article, we argue on the need for inclusive responses to public health emergencies in Africa using COVID-19 as a case example. Africa's response to public health emergencies needs to recognize that for every marginalized/vulnerable group, it is important to strategize to address their particular needs in such a way to surmount any barrier to the right to health. For Africa's public health response to be more inclusive, we therefore need to be more strategic and proactive in reaching out to specific groups and to identify and address their needs. Strengthening the healthcare systems of African countries through increased political will, increased funding to health care, collaboration and cooperation among stakeholders, and effective leadership remains essential in ensuring inclusive responses to health emergencies.", "doi": "10.4269/ajtmh.20-1485", "pmid": "33331263", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2020-12-21T08:57:29.223Z", "modified": "2021-02-26T08:47:00.142Z"}, {"entity": "publication", "iuid": "a8cae6475f344161a6e12d8f1616c9c2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8cae6475f344161a6e12d8f1616c9c2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8cae6475f344161a6e12d8f1616c9c2"}}, "title": "The coronavirus pandemic: a pitfall or a fast-track for validating cell therapy products?", "authors": [{"family": "Khoury", "given": "Maroun", "initials": "M"}, {"family": "Ikonomou", "given": "Laertis", "initials": "L"}, {"family": "Dominici", "given": "Massimo", "initials": "M"}, {"family": "Le Blanc", "given": "Katarina", "initials": "K"}, {"family": "Levine", "given": "Bruce L", "initials": "BL"}, {"family": "Weiss", "given": "Dan J", "initials": "DJ"}], "type": "journal article", "published": "2020-12-14", "journal": {"title": "Stem Cells Dev", "issn": "1557-8534", "volume": null, "issue": null, "issn-l": null}, "abstract": "The global COVID-19 pandemic has prompted urgent need for potential therapies for severe respiratory consequences resulting from coronavirus infection. New therapeutic agents that will attenuate ongoing inflammation and, at the same time, promote regeneration of injured lung epithelial cells are urgently needed. Cell-based therapies, primarily involving mesenchymal stromal cells (MSCs) and their derivatives are currently being investigated worldwide for SARS-CoV-2-induced lung diseases. A significant number of academic centers and companies globally have already initiated such trials. At a time of unprecedented need, it is it is also foreseen that distressed families, and caregivers to seek all available options including access to cell-based and other investigational products, even prior to its regulatory approval. This should not be an excuse for opportunists to sell or advertise unproven therapies of any kind. \"Compassionate use\" should be conducted in the context of a clinical investigation framed by strict ethical and regulatory permissions, with the goal of obtaining mechanistic information wherever possible.", "doi": "10.1089/scd.2020.0122", "pmid": "33307968", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-21T10:19:40.918Z", "modified": "2020-12-21T10:19:40.956Z"}, {"entity": "publication", "iuid": "79337d3b64b34c6aaa6f4da531eb17d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79337d3b64b34c6aaa6f4da531eb17d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79337d3b64b34c6aaa6f4da531eb17d9"}}, "title": "The Impact of the COVID-19 Pandemic on People with Diabetes and Diabetes Services: A pan-European Survey of Diabetes Specialist Nurses undertaken by the Foundation of European Nurses in Diabetes survey consortium.", "authors": [{"family": "Forde", "given": "Rita", "initials": "R"}, {"family": "Arente", "given": "Liga", "initials": "L"}, {"family": "Ausili", "given": "Davide", "initials": "D"}, {"family": "De Backer", "given": "Kristin", "initials": "K"}, {"family": "Due-Christensen", "given": "Mette", "initials": "M"}, {"family": "Epps", "given": "Amanda", "initials": "A"}, {"family": "Fitzpatrick", "given": "Anne", "initials": "A"}, {"family": "Grixti", "given": "Moira", "initials": "M"}, {"family": "Groen", "given": "Sijda", "initials": "S"}, {"family": "Halkoaho", "given": "Arja", "initials": "A"}, {"family": "Huber", "given": "Claudia", "initials": "C"}, {"family": "Iversen", "given": "Marjolein M", "initials": "MM"}, {"family": "Johansson", "given": "Unn-Britt", "initials": "UB"}, {"family": "Leippert", "given": "Claudia", "initials": "C"}, {"family": "Ozcan", "given": "Seyda", "initials": "S"}, {"family": "Parker", "given": "Julie", "initials": "J"}, {"family": "Paiva", "given": "Ana Christina", "initials": "AC"}, {"family": "Sanpetreanu", "given": "Adina", "initials": "A"}, {"family": "Savet", "given": "Marie-Alice", "initials": "MA"}, {"family": "Rosana", "given": "Svetic-Cisic", "initials": "SC"}, {"family": "Szewczyk", "given": "Alicja", "initials": "A"}, {"family": "Valverde", "given": "Maite", "initials": "M"}, {"family": "Vlachou", "given": "Eugenia", "initials": "E"}, {"family": "Forbes", "given": "Angus", "initials": "A"}, {"family": "FEND COVID-19 consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2020-12-14", "journal": {"title": "Diabet Med", "issn": "1464-5491", "volume": null, "issue": null, "pages": "e14498", "issn-l": null}, "abstract": "To describe diabetes nurses' perspectives on the impact of the COVID-19 pandemic on people with diabetes and diabetes services across Europe.\n\nAn online survey developed using a rapid Delphi method. The survey was translated into 17 different languages and disseminated electronically in 27 countries via national diabetes nurse networks.\n\nSurvey responses from 1829 diabetes nurses were included in the analysis. The responses indicated that 28% (n=504) and 48% (n=873) of diabetes nurses felt the COVID-19 pandemic had impacted 'a lot' on the physical and psychological risks of people with diabetes, respectively. The following clinical problems were identified as having increased 'a lot': anxiety 82% (n=1486); diabetes distress 65% (n=1189); depression 49% (n= 893); acute hyperglycaemia 39% (n=710); and foot complications 17% (n=323). Forty-seven percent (n=771) of respondents identified that the level of care provided to people with diabetes had declined either extremely or quite severely. Self-management support, diabetes education and psychological support were rated by diabetes nurse respondents as having declined extremely or quite severely during the COVID-19 pandemic by 31% (n=499), 63% (n=1,027) and 34% (n=551), respectively.\n\nThe findings show that diabetes nurses across Europe have seen significant increases in both physical and psychological problems in their patient populations during COVID-19. The data also show that clinical diabetes services have been significantly disrupted. As the COVID-19 situation continues we need to adapt care systems with some urgency to minimise the impact of the pandemic on the diabetes population.", "doi": "10.1111/dme.14498", "pmid": "33314244", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-21T10:17:40.765Z", "modified": "2021-01-08T08:18:44.786Z"}, {"entity": "publication", "iuid": "5c6f4fbc1a2247c395f119b0d31efabc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c6f4fbc1a2247c395f119b0d31efabc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c6f4fbc1a2247c395f119b0d31efabc"}}, "title": "Screening for high amounts of SARS-CoV-2 identifies pre-symptomatic subjects among healthy healthcare workers", "authors": [{"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Elfstr\u00f6m", "given": "K Miriam", "initials": "KM"}, {"family": "Blomqvist", "given": "Jonas", "initials": "J"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M"}, {"family": "Eklund", "given": "Carina", "initials": "C"}, {"family": "Boulund", "given": "Fredrik", "initials": "F"}, {"family": "Lagheden", "given": "Camilla", "initials": "C"}, {"family": "Hamsten", "given": "Marica", "initials": "M"}, {"family": "Nordqvist-Kleppe", "given": "Sara", "initials": "S"}, {"family": "Seifert", "given": "Maike", "initials": "M"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Olofsson", "given": "Jennie", "initials": "J"}, {"family": "Andersson", "given": "Eni", "initials": "E"}, {"family": "Falk", "given": "August Jernbom", "initials": "AJ"}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S"}, {"family": "Hultin", "given": "Emilie", "initials": "E"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Pimenoff", "given": "Ville N", "initials": "VN"}, {"family": "Hassan", "given": "Sadaf", "initials": "S"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Mattsson", "given": "Johan", "initials": "J"}, {"family": "M\u00fchr", "given": "Laila Sara Arroyo", "initials": "LSA"}, {"family": "Lundgren", "given": "Kalle Conneryd", "initials": "KC"}], "type": "posted-content", "published": "2020-12-14", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.13.20248122", "pmid": null, "labels": {"Type: Preprint": null, "Research Area: High-throughput and high-content serology": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}, {"db": "ClinicalTrials.gov", "key": "NCT04411576", "description": null}], "notes": [], "created": "2020-12-18T07:50:57.449Z", "modified": "2023-06-19T14:24:06.940Z"}, {"entity": "publication", "iuid": "0a55e1fb2e0d4307820500d6d439b2c4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a55e1fb2e0d4307820500d6d439b2c4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a55e1fb2e0d4307820500d6d439b2c4"}}, "title": "Rapid Assessment of Price Instability and Paucity of Medicines and Protection for COVID-19 Across Asia: Findings and Public Health Implications for the Future.", "authors": [{"family": "Godman", "given": "Brian", "initials": "B"}, {"family": "Haque", "given": "Mainul", "initials": "M"}, {"family": "Islam", "given": "Salequl", "initials": "S"}, {"family": "Iqbal", "given": "Samiul", "initials": "S"}, {"family": "Urmi", "given": "Umme Laila", "initials": "UL"}, {"family": "Kamal", "given": "Zubair Mahmood", "initials": "ZM"}, {"family": "Shuvo", "given": "Shahriar Ahmed", "initials": "SA"}, {"family": "Rahman", "given": "Aminur", "initials": "A"}, {"family": "Kamal", "given": "Mustafa", "initials": "M"}, {"family": "Haque", "given": "Monami", "initials": "M"}, {"family": "Jahan", "given": "Iffat", "initials": "I"}, {"family": "Islam", "given": "Md Zakirul", "initials": "MZ"}, {"family": "Hossain", "given": "Mohammad Monir", "initials": "MM"}, {"family": "Kumar", "given": "Santosh", "initials": "S"}, {"family": "Charan", "given": "Jaykaran", "initials": "J"}, {"family": "Bhatt", "given": "Rohan", "initials": "R"}, {"family": "Dutta", "given": "Siddhartha", "initials": "S"}, {"family": "Abhayanand", "given": "Jha Pallavi", "initials": "JP"}, {"family": "Sharma", "given": "Yesh", "initials": "Y"}, {"family": "Saleem", "given": "Zikria", "initials": "Z"}, {"family": "Phuong", "given": "Thuy Nguyen Thi", "initials": "TNT"}, {"family": "Kwon", "given": "Hye-Young", "initials": "HY"}, {"family": "Kurdi", "given": "Amanj", "initials": "A"}, {"family": "Wale", "given": "Janney", "initials": "J"}, {"family": "Sefah", "given": "Israel", "initials": "I"}], "type": "journal article", "published": "2020-12-14", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "585832", "issn-l": "2296-2565"}, "abstract": "Background: Countries have introduced a variety of measures to prevent and treat COVID-19 with medicines and personal protective equipment (PPE), with some countries adopting preventative strategies earlier than others. However, there has been considerable controversy surrounding some treatments. This includes hydroxychloroquine where the initial hype and misinformation lead to shortages, price rises and suicides. Price rises and shortages have also been seen for PPE. Such activities can have catastrophic effects on patients where there are high co-payment levels and issues of affordability. Consequently, there is a need to investigate this further. Objective: Assess changes in the availability, utilization and prices of relevant medicines and PPE during the pandemic among a range of Asian countries. Our approach: Narrative literature review combined with interviews among community pharmacists to assess changes in consumption, prices and shortages of medicines and PPE from the beginning of March 2020 until end of May 2020. In addition, suggestions on ways to reduce misinformation. Results: 308 pharmacists took part from five Asian countries. There was an appreciable increase in the utilization of antimicrobials in Pakistan (in over 88% of pharmacies), with lower increases or no change in Bangladesh, India, Malaysia and Vietnam. Encouragingly, there was increased use of vitamins/immune boosters and PPE across the countries, as well as limited price rises for antimicrobials in India, Malaysia and Vietnam, although greater price rises seen for analgesics and vitamin C/immune boosters. Appreciable price increases were also seen for PPE across some countries. Conclusion: Encouraging to see increases in utilization of vitamins/immune boosters and PPE. However, increases in the utilization and prices of antimicrobials is a concern that needs addressing alongside misinformation and any unintended consequences from the pandemic. Community pharmacists can play a key role in providing evidence-based advice, helping to moderate prices, as well as helping address some of the unintended consequences of the pandemic.", "doi": "10.3389/fpubh.2020.585832", "pmid": "33381485", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7767884"}, {"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-07T12:08:28.441Z", "modified": "2021-02-26T08:46:59.826Z"}, {"entity": "publication", "iuid": "31fa7f460b4b485b93fa9345954bb9ea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/31fa7f460b4b485b93fa9345954bb9ea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/31fa7f460b4b485b93fa9345954bb9ea"}}, "title": "Covid-19: Sweden considers tougher restrictions as ICU beds near capacity.", "authors": [{"family": "Paterlini", "given": "Marta", "initials": "M"}], "type": "journal article", "published": "2020-12-14", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "371", "issue": null, "pages": "m4833", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m4833", "pmid": "33318030", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-21T10:16:30.160Z", "modified": "2020-12-21T10:16:30.188Z"}, {"entity": "publication", "iuid": "55331c5e35f74d09a14cbe3534f72131", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/55331c5e35f74d09a14cbe3534f72131.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/55331c5e35f74d09a14cbe3534f72131"}}, "title": "Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features.", "authors": [{"family": "Hassan", "given": "Sk Sarif", "initials": "SS"}, {"family": "Ghosh", "given": "Shinjini", "initials": "S"}, {"family": "Attrish", "given": "Diksha", "initials": "D"}, {"family": "Choudhury", "given": "Pabitra Pal", "initials": "PP"}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA"}, {"family": "Uhal", "given": "Bruce D", "initials": "BD"}, {"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN"}, {"family": "Seyran", "given": "Murat", "initials": "M"}, {"family": "Pizzol", "given": "Damiano", "initials": "D"}, {"family": "Adadi", "given": "Parise", "initials": "P"}, {"family": "Soares", "given": "Antonio", "initials": "A"}, {"family": "El-Aziz", "given": "Tarek Mohamed Abd", "initials": "TMA"}, {"family": "Kandimalla", "given": "Ramesh", "initials": "R"}, {"family": "Tambuwala", "given": "Murtaza M", "initials": "MM"}, {"family": "Azad", "given": "Gajendra Kumar", "initials": "GK"}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Baetas-da-Cruz", "given": "Wagner", "initials": "W"}, {"family": "Takayama", "given": "Kazuo", "initials": "K"}, {"family": "Serrano-Aroca", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "Chauhan", "given": "Gaurav", "initials": "G"}, {"family": "Palu", "given": "Giorgio", "initials": "G"}, {"family": "Brufsky", "given": "Adam M", "initials": "AM"}], "type": "journal article", "published": "2020-12-13", "journal": {"title": "Molecules", "issn": "1420-3049", "volume": "25", "issue": "24", "pages": "5906", "issn-l": null}, "abstract": "Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22-42, aa 79-84, and aa 330-393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species.", "doi": "10.3390/molecules25245906", "pmid": "33322198", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "molecules25245906"}], "notes": [], "created": "2020-12-21T10:03:41.914Z", "modified": "2021-02-26T08:45:48.163Z"}, {"entity": "publication", "iuid": "ba31a9e9933a4ca68a0efcbeb9cad020", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ba31a9e9933a4ca68a0efcbeb9cad020.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ba31a9e9933a4ca68a0efcbeb9cad020"}}, "title": "The role of extracellular DNA in COVID-19: clues from inflamm-aging.", "authors": [{"family": "Storci", "given": "Gianluca", "initials": "G"}, {"family": "Bonifazi", "given": "Francesca", "initials": "F"}, {"family": "Garagnani", "given": "Paolo", "initials": "P"}, {"family": "Olivieri", "given": "Fabiola", "initials": "F"}, {"family": "Bonaf\u00e8", "given": "Massimiliano", "initials": "M"}], "type": "journal article", "published": "2020-12-12", "journal": {"title": "Ageing Res Rev", "issn": "1872-9649", "volume": "66", "issue": null, "pages": "101234", "issn-l": "1568-1637"}, "abstract": "Epidemiological data convey severe prognosis and high mortality rate for COVID-19 in elderly men affected by age-related diseases. These subjects develop local and systemic hyper-inflammation, which are associated with thrombotic complications and multi-organ failure. Therefore, understanding SARS-CoV-2 induced hyper-inflammation in elderly men is a pressing need. Here we focus on the role of extracellular DNA, mainly mitochondrial DNA (mtDNA) and telomeric DNA (telDNA) in the modulation of systemic inflammation in these subjects. In particular, extracellular mtDNA is regarded as a powerful trigger of the inflammatory response. On the contrary, extracellular telDNA pool is estimated to be capable of inhibiting a variety of inflammatory pathways. In turn, we underpin that telDNA reservoir is progressively depleted during aging, and that it is scarcer in men than in women. We propose that an increase in extracellular mtDNA, concomitant with the reduction of the anti-inflammatory telDNA reservoir may explain hyper-inflammation in elderly male affected by COVID-19. This scenario is reminiscent of inflamm-aging, the portmanteau word that depicts how aging and aging related diseases are intimately linked to inflammation.", "doi": "10.1016/j.arr.2020.101234", "pmid": "33321254", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1568-1637(20)30369-X"}], "notes": [], "created": "2020-12-21T10:05:39.471Z", "modified": "2021-01-10T18:17:21.167Z"}, {"entity": "publication", "iuid": "353c836a008149b6b1884eaf9e5c3dcb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/353c836a008149b6b1884eaf9e5c3dcb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/353c836a008149b6b1884eaf9e5c3dcb"}}, "title": "The MERS-CoV receptor gene is among COVID-19 risk factors inherited from Neandertals", "authors": [{"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "Paabo", "given": "Svante", "initials": "S"}], "type": "posted-content", "published": "2020-12-12", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.11.422139", "pmid": null, "labels": {"Type: Preprint": null, "Category: Genomics & transcriptomics": null, "Category: Other": null}, "xrefs": [{"db": "URL", "key": "http://cdna.eva.mpg.de/neandertal/Vindija/VCF/", "description": "Croatian Neandertal genome"}, {"db": "URL", "key": "https://bioinf.eva.mpg.de/jbrowse/", "description": "Croatian Neandertal genome"}, {"db": "URL", "key": "http://ftp.1000genomes.ebi.ac.uk/vol1/ftp/release/20130502/", "description": "Modern human genomes at the 1000 Genomes Project"}, {"db": "URL", "key": "https://www.covid19hg.org/results/", "description": "GWAS summary statistics (round 4 release: A/B2_ALL_eur_leave_23andme)"}], "notes": [], "created": "2021-01-08T08:41:17.454Z", "modified": "2021-02-26T08:46:13.031Z"}, {"entity": "publication", "iuid": "e333d7fb14ef4f8ab958615325a0d36d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e333d7fb14ef4f8ab958615325a0d36d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e333d7fb14ef4f8ab958615325a0d36d"}}, "title": "Home-Based Care for People with Alzheimer's Disease and Related Dementias (ADRD) during COVID-19 Pandemic: From Challenges to Solutions.", "authors": [{"family": "Sm-Rahman", "given": "Atiqur", "initials": "A"}, {"family": "Lo", "given": "Chih Hung", "initials": "CH"}, {"family": "Ramic", "given": "Azra", "initials": "A"}, {"family": "Jahan", "given": "Yasmin", "initials": "Y"}], "type": "journal article", "published": "2020-12-12", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "17", "issue": "24", "pages": "9303", "issn-l": null}, "abstract": "There has been supporting evidence that older adults with underlying health conditions form the majority of the fatal cases in the current novel coronavirus disease (COVID-19) pandemic. While the impact of COVID-19 is affecting the general public, it is clear that these distressful experiences will be magnified in older adults, particularly people living with Alzheimer's disease and related dementia (ADRD), making them the most vulnerable group during this time. People with differing degrees of ADRD are especially susceptible to the virus, not only because of their difficulties in assessing the threat or remembering the safety measures, but also because of the likelihood to be subject to other risk factors, such as lack of proper care and psychological issues. Therefore, in this article, we will discuss the challenges related to home-based care for people with ADRD during a pandemic and propose a formulation of systematic solutions to address these challenges and to alleviate the social and economic impact resulting from the crisis.", "doi": "10.3390/ijerph17249303", "pmid": "33322696", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph17249303"}], "notes": [], "created": "2020-12-21T10:02:09.026Z", "modified": "2021-02-26T08:45:48.802Z"}, {"entity": "publication", "iuid": "e6263b3ecca646cf92defcc715504da1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6263b3ecca646cf92defcc715504da1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6263b3ecca646cf92defcc715504da1"}}, "title": "Will the COVID-19 pandemic lead to a tsunami of suicides? A Swedish nationwide analysis of historical and 2020 data", "authors": [{"family": "R\u00fcck", "given": "Christian", "initials": "C"}, {"family": "Mataix-Cols", "given": "David", "initials": "D"}, {"family": "Malki", "given": "Kinda", "initials": "K"}, {"family": "Adler", "given": "Mats", "initials": "M"}, {"family": "Flygare", "given": "Oskar", "initials": "O"}, {"family": "Runeson", "given": "Bo", "initials": "B"}, {"family": "Sidorchuk", "given": "Anna", "initials": "A"}], "type": "posted-content", "published": "2020-12-11", "journal": {"title": "", "issn": null, "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1101/2020.12.10.20244699", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-09T19:31:08.617Z", "modified": "2021-06-09T19:31:08.617Z"}, {"entity": "publication", "iuid": "ec1877b0d29b4867afe2f155af937d3b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec1877b0d29b4867afe2f155af937d3b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec1877b0d29b4867afe2f155af937d3b"}}, "title": "Virtual and In Vitro Antiviral Screening Revive Therapeutic Drugs for COVID-19", "authors": [{"family": "Bocci", "given": "Giovanni", "initials": "G"}, {"family": "Bradfute", "given": "Steven B", "initials": "SB"}, {"family": "Ye", "given": "Chunyan", "initials": "C"}, {"family": "Garcia", "given": "Matthew J", "initials": "MJ"}, {"family": "Parvathareddy", "given": "Jyothi", "initials": "J"}, {"family": "Reichard", "given": "Walter", "initials": "W"}, {"family": "Surendranathan", "given": "Surekha", "initials": "S"}, {"family": "Bansal", "given": "Shruti", "initials": "S"}, {"family": "Bologa", "given": "Cristian G", "initials": "CG"}, {"family": "Perkins", "given": "Douglas J", "initials": "DJ"}, {"family": "Jonsson", "given": "Colleen B", "initials": "CB"}, {"family": "Sklar", "given": "Larry A", "initials": "LA"}, {"family": "Oprea", "given": "Tudor I", "initials": "TI"}], "type": "journal-article", "published": "2020-12-11", "journal": {"title": "ACS Pharmacol. Transl. Sci.", "issn": "2575-9108", "issn-l": null, "volume": "3", "issue": "6", "pages": "1278-1292"}, "abstract": "The urgent need for a cure for early phase COVID-19 infected patients critically underlines drug repositioning strategies able to efficiently identify new and reliable treatments by merging computational, experimental, and pharmacokinetic expertise. Here we report new potential therapeutics for COVID-19 identified with a combined virtual and experimental screening strategy and selected among already approved drugs. We used hydroxychloroquine (HCQ), one of the most studied drugs in current clinical trials, as a reference template to screen for structural similarity against a library of almost 4000 approved drugs. The top-ranked drugs, based on structural similarity to HCQ, were selected for in vitro antiviral assessment. Among the selected drugs, both zuclopenthixol and nebivolol efficiently block SARS-CoV-2 infection with EC50 values in the low micromolar range, as confirmed by independent experiments. The anti-SARS-CoV-2 potential of ambroxol, amodiaquine, and its active metabolite (N-monodesethyl amodiaquine) is also discussed. In trying to understand the \"hydroxychloroquine\" mechanism of action, both pKa and the HCQ aromatic core may play a role. Further, we show that the amodiaquine metabolite and, to a lesser extent, zuclopenthixol and nebivolol are active in a SARS-CoV-2 titer reduction assay. Given the need for improved efficacy and safety, we propose zuclopenthixol, nebivolol, and amodiaquine as potential candidates for clinical trials against the early phase of the SARS-CoV-2 infection and discuss their potential use as adjuvant to the current (i.e., remdesivir and favipiravir) COVID-19 therapeutics.", "doi": "10.1021/acsptsci.0c00131", "pmid": "33330842", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-01-10T18:12:02.890Z", "modified": "2021-02-26T08:45:25.930Z"}, {"entity": "publication", "iuid": "8f4719a29b274ec78a4692ec6e333afe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f4719a29b274ec78a4692ec6e333afe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f4719a29b274ec78a4692ec6e333afe"}}, "title": "Thermal inactivation of COVID-19 specimens improves RNA quality and quantity.", "authors": [{"family": "Hemati", "given": "Maral", "initials": "M"}, {"family": "Soosanabadi", "given": "Mohsen", "initials": "M"}, {"family": "Ghorashi", "given": "Tahereh", "initials": "T"}, {"family": "Ghaffari", "given": "Hadi", "initials": "H"}, {"family": "Vahedi", "given": "Azadeh", "initials": "A"}, {"family": "Sabbaghian", "given": "Elaheh", "initials": "E"}, {"family": "Rasouli Nejad", "given": "Zahra", "initials": "Z"}, {"family": "Salati", "given": "Amir", "initials": "A"}, {"family": "Danaei", "given": "Navid", "initials": "N"}, {"family": "Kokhaei", "given": "Parviz", "initials": "P"}], "type": "journal article", "published": "2020-12-11", "journal": {"title": "J Cell Physiol", "issn": "1097-4652", "volume": null, "issue": null, "issn-l": null}, "abstract": "The rapid spread of coronavirus disease 2019 (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2, poses a huge demand for immediate diagnosis. Real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) of nasopharyngeal (NP) and oropharyngeal (OP) swabs have been used to confirm the clinical diagnosis. To avoid the risk of viral-exposure of laboratory workers, thermal inactivation is currently recommended but has unknown effects on the accuracy of the rRT-PCR results. Thirty-six NP/OP specimens were collected from COVID-19 patients and subjected to thermal inactivation (60\u00b0C for 30 min) or the RNA extraction processes to activate the form. Here, our data showed that the concentration of extracted-RNA increases upon thermal inactivation compared to the active form (p = .028). Significantly higher levels of RNA copy number were obtained in inactivated compared to the active samples for both N and ORF1ab genes (p = .009, p = .032, respectively). Thermal inactivation elevated concentration and copy number of extracted-RNA, possibly through viral-capsid degradation and/or nucleoprotein denaturation.", "doi": "10.1002/jcp.30206", "pmid": "33305832", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "NA", "key": "All data is included in the paper", "description": null}], "notes": [], "created": "2020-12-13T07:09:52.986Z", "modified": "2021-11-18T10:50:34.005Z"}, {"entity": "publication", "iuid": "436a8679ea6f4aabb1a29e5b881218c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/436a8679ea6f4aabb1a29e5b881218c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/436a8679ea6f4aabb1a29e5b881218c5"}}, "title": "SARS-CoV-2 genome diversity at the binding sites of oligonucleotides used for COVID-19 diagnosis", "authors": [{"family": "Valieris", "given": "Renan", "initials": "R"}, {"family": "Kowaslki", "given": "Michal", "initials": "M"}, {"family": "Frolova", "given": "Alina", "initials": "A"}, {"family": "Wydmanski", "given": "Witold", "initials": "W"}, {"family": "Foox", "given": "Johnathan", "initials": "J"}, {"family": "Torrezan", "given": "Giovana", "initials": "G"}, {"family": "Pospiech", "given": "Ewelina", "initials": "E"}, {"family": "Branicki", "given": "Wojciech", "initials": "W"}, {"family": "Venkateswaran", "given": "Kasthuri", "initials": "K"}, {"family": "Prithiviraj", "given": "Bharath", "initials": "B"}, {"family": "Dhamodharan", "given": "Ramasamy", "initials": "R"}, {"family": "Udekwu", "given": "Klas", "initials": "K"}, {"family": "Nunes", "given": "Diana", "initials": "D"}, {"family": "Carraro", "given": "Dirce", "initials": "D"}, {"family": "Mason", "given": "Christopher", "initials": "C"}, {"family": "Labaj", "given": "Pawel", "initials": "P"}, {"family": "Silva", "given": "Israel", "initials": "I"}, {"family": "Dias-Neto", "given": "Emmanuel", "initials": "E"}], "type": "posted-content", "published": "2020-12-11", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.10.20236943", "pmid": null, "labels": {"Category: Genomics & transcriptomics": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2020-12-13T07:59:44.049Z", "modified": "2021-03-10T15:25:26.218Z"}, {"entity": "publication", "iuid": "9464140b8b6d4cc6b78280e9bf8d918b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9464140b8b6d4cc6b78280e9bf8d918b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9464140b8b6d4cc6b78280e9bf8d918b"}}, "title": "Picomolar SARS-CoV-2 Neutralization Using Multi-Arm PEG Nanobody Constructs.", "authors": [{"family": "Moliner-Morro", "given": "Ainhoa", "initials": "A"}, {"family": "J Sheward", "given": "Daniel", "initials": "D"}, {"family": "Karl", "given": "Vivien", "initials": "V"}, {"family": "Perez Vidakovics", "given": "Laura", "initials": "L"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}, {"family": "Hanke", "given": "Leo", "initials": "L"}], "type": "journal article", "published": "2020-12-11", "journal": {"title": "Biomolecules", "issn": "2218-273X", "issn-l": null, "volume": "10", "issue": "12", "pages": null}, "abstract": "Multivalent antibody constructs have a broad range of clinical and biotechnological applications. Nanobodies are especially useful as components for multivalent constructs as they allow increased valency while maintaining a small molecule size. We here describe a novel, rapid method for the generation of bi- and multivalent nanobody constructs with oriented assembly by Cu-free strain promoted azide-alkyne click chemistry (SPAAC). We used sortase A for ligation of click chemistry functional groups site-specifically to the C-terminus of nanobodies before creating C-to-C-terminal nanobody fusions and 4-arm polyethylene glycol (PEG) tetrameric nanobody constructs. We demonstrated the viability of this approach by generating constructs with the SARS-CoV-2 neutralizing nanobody Ty1. We compared the ability of the different constructs to neutralize SARS-CoV-2 pseudotyped virus and infectious virus in neutralization assays. The generated dimers neutralized the virus similarly to a nanobody-Fc fusion variant, while a 4-arm PEG based tetrameric Ty1 construct dramatically enhanced neutralization of SARS-CoV-2, with an IC 50 in the low picomolar range.", "doi": "10.3390/biom10121661", "pmid": "33322557", "labels": {"Type: Journal article": null, "Funder: H2020": null, "Funder: VR: Special COVID-19 funding": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Proteins": null}, "xrefs": [{"db": "pii", "key": "biom10121661"}], "notes": [], "created": "2020-12-18T07:54:12.206Z", "modified": "2021-02-26T08:47:18.845Z"}, {"entity": "publication", "iuid": "ddbdaab95394488cbf53747695bea4e4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ddbdaab95394488cbf53747695bea4e4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ddbdaab95394488cbf53747695bea4e4"}}, "title": "Genetic mechanisms of critical illness in Covid-19.", "authors": [{"family": "Pairo-Castineira", "given": "Erola", "initials": "E"}, {"family": "Clohisey", "given": "Sara", "initials": "S"}, {"family": "Klaric", "given": "Lucija", "initials": "L"}, {"family": "Bretherick", "given": "Andrew D", "initials": "AD"}, {"family": "Rawlik", "given": "Konrad", "initials": "K"}, {"family": "Pasko", "given": "Dorota", "initials": "D"}, {"family": "Walker", "given": "Susan", "initials": "S"}, {"family": "Parkinson", "given": "Nick", "initials": "N"}, {"family": "Fourman", "given": "Max Head", "initials": "MH"}, {"family": "Russell", "given": "Clark D", "initials": "CD"}, {"family": "Furniss", "given": "James", "initials": "J"}, {"family": "Richmond", "given": "Anne", "initials": "A"}, {"family": "Gountouna", "given": "Elvina", "initials": "E"}, {"family": "Wrobel", "given": "Nicola", "initials": "N"}, {"family": "Harrison", "given": "David", "initials": "D"}, {"family": "Wang", "given": "Bo", "initials": "B"}, {"family": "Wu", "given": "Yang", "initials": "Y"}, {"family": "Meynert", "given": "Alison", "initials": "A"}, {"family": "Griffiths", "given": "Fiona", "initials": "F"}, {"family": "Oosthuyzen", "given": "Wilna", "initials": "W"}, {"family": "Kousathanas", "given": "Athanasios", "initials": "A"}, {"family": "Moutsianas", "given": "Loukas", "initials": "L"}, {"family": "Yang", "given": "Zhijian", "initials": "Z"}, {"family": "Zhai", "given": "Ranran", "initials": "R"}, {"family": "Zheng", "given": "Chenqing", "initials": "C"}, {"family": "Grimes", "given": "Graeme", "initials": "G"}, {"family": "Beale", "given": "Rupert", "initials": "R"}, {"family": "Millar", "given": "Jonathan", "initials": "J"}, {"family": "Shih", "given": "Barbara", "initials": "B"}, {"family": "Keating", "given": "Sean", "initials": "S"}, {"family": "Zechner", "given": "Marie", "initials": "M"}, {"family": "Haley", "given": "Chris", "initials": "C"}, {"family": "Porteous", "given": "David J", "initials": "DJ"}, {"family": "Hayward", "given": "Caroline", "initials": "C"}, {"family": "Yang", "given": "Jian", "initials": "J"}, {"family": "Knight", "given": "Julian", "initials": "J"}, {"family": "Summers", "given": "Charlotte", "initials": "C"}, {"family": "Shankar-Hari", "given": "Manu", "initials": "M"}, {"family": "Klenerman", "given": "Paul", "initials": "P"}, {"family": "Turtle", "given": "Lance", "initials": "L"}, {"family": "Ho", "given": "Antonia", "initials": "A"}, {"family": "Moore", "given": "Shona C", "initials": "SC"}, {"family": "Hinds", "given": "Charles", "initials": "C"}, {"family": "Horby", "given": "Peter", "initials": "P"}, {"family": "Nichol", "given": "Alistair", "initials": "A"}, {"family": "Maslove", "given": "David", "initials": "D"}, {"family": "Ling", "given": "Lowell", "initials": "L"}, {"family": "McAuley", "given": "Danny", "initials": "D"}, {"family": "Montgomery", "given": "Hugh", "initials": "H"}, {"family": "Walsh", "given": "Timothy", "initials": "T"}, {"family": "Pereira", "given": "Alex", "initials": "A"}, {"family": "Renieri", "given": "Alessandra", "initials": "A"}, {"family": "GenOMICC Investigators", "given": "", "initials": ""}, {"family": "ISARICC Investigators", "given": "", "initials": ""}, {"family": "COVID-19 Human Genetics Initiative", "given": "", "initials": ""}, {"family": "23andMe Investigators", "given": "", "initials": ""}, {"family": "BRACOVID Investigators", "given": "", "initials": ""}, {"family": "Gen-COVID Investigators", "given": "", "initials": ""}, {"family": "Shen", "given": "Xia", "initials": "X"}, {"family": "Ponting", "given": "Chris P", "initials": "CP"}, {"family": "Fawkes", "given": "Angie", "initials": "A"}, {"family": "Tenesa", "given": "Albert", "initials": "A"}, {"family": "Caulfield", "given": "Mark", "initials": "M"}, {"family": "Scott", "given": "Richard", "initials": "R"}, {"family": "Rowan", "given": "Kathy", "initials": "K"}, {"family": "Murphy", "given": "Lee", "initials": "L"}, {"family": "Openshaw", "given": "Peter J M", "initials": "PJM"}, {"family": "Semple", "given": "Malcolm G", "initials": "MG"}, {"family": "Law", "given": "Andrew", "initials": "A"}, {"family": "Vitart", "given": "Veronique", "initials": "V"}, {"family": "Wilson", "given": "James F", "initials": "JF"}, {"family": "Baillie", "given": "J Kenneth", "initials": "JK"}], "type": "journal article", "published": "2020-12-11", "journal": {"title": "Nature", "issn": "1476-4687", "volume": null, "issue": null, "issn-l": "0028-0836"}, "abstract": "Host-mediated lung inflammation is present, 1 and drives mortality,2 in critical illness caused by Covid-19. Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development.3 Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study(GWAS) in 2244 critically ill Covid-19 patients from 208 UK intensive care units (ICUs). We identify and replicate novel genome-wide significant associations, on chr12q24.13 (rs10735079, p=1.65 [Formula: see text] 10-8) in a gene cluster encoding antiviral restriction enzyme activators (OAS1, OAS2, OAS3), on chr19p13.2 (rs2109069, p=2.3 [Formula: see text] 10-12) near the gene encoding tyrosine kinase 2 (TYK2), on chr19p13.3 (rs2109069, p=3.98 [Formula: see text] 10-12) within the gene encoding dipeptidyl peptidase 9 (DPP9), and on chr21q22.1 (rs2236757, p=4.99 [Formula: see text] 10-8) in the interferon receptor gene IFNAR2. We identify potential targets for repurposing of licensed medications: using Mendelian randomisation we found evidence in support of a causal link from low expression of IFNAR2, and high expression of TYK2, to life-threatening disease; transcriptome-wide association in lung tissue revealed that high expression of the monocyte/macrophage chemotactic receptor CCR2 is associated with severe Covid-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms, and mediators of inflammatory organ damage in Covid-19. Both mechanisms may be amenable to targeted treatment with existing drugs. Large-scale randomised clinical trials will be essential before any change to clinical practice.", "doi": "10.1038/s41586-020-03065-y", "pmid": "33307546", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null}, "xrefs": [], "notes": [], "created": "2020-12-13T07:06:59.152Z", "modified": "2021-02-26T08:45:14.476Z"}, {"entity": "publication", "iuid": "7fe2976d7ac044c290eda708d6c87267", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7fe2976d7ac044c290eda708d6c87267.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7fe2976d7ac044c290eda708d6c87267"}}, "title": "Serum neopterin levels in relation to mild and severe COVID-19", "authors": [{"family": "Robertson", "given": "Josefina", "initials": "J"}, {"family": "Gostner", "given": "Johanna M", "initials": "JM"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "L"}, {"family": "Fuchs", "given": "Dietmar", "initials": "D"}, {"family": "Gisslen", "given": "Magnus", "initials": "M"}], "type": "posted-content", "published": "2020-12-10", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "issn-l": null, "volume": "Dec 10; 20", "issue": "1", "pages": "942"}, "abstract": "Background The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, is rapidly spreading worldwide. There is limited information about prognostic markers that could help clinicians to identify COVID-19 patients with a poor prognosis. Serum levels of the immune activation marker neopterin has shown to be of prognostic value in patients with SARS. The aim of this study was to investigate whether serum neopterin is associated with the severity of COVID-19. Methods We included 34 patients with confirmed COVID-19 between March 3 and March 30, 2020. Fifteen patients had mild disease and did not require hospitalization, whereas 19 patients developed severe COVID-19 requiring intensive care. Concentrations of serum neopterin, tryptophan, and kynurenine were measured at and repeatedly after inclusion. Results We found a more than two-fold higher mean concentration of neopterin in severely ill patients (mean value 42.0 nmol/L (SD 18.2)) compared to patients with mild symptoms (16.9 nmol/L (SD 11.0)). All of the severe cases had elevated neopterin concentrations (>9.1 nmol/L) at the initial sampling with values ranging from 17.2 to 86.7 nmol/L. In comparison, 10 of 15 patients with mild disease had neopterin levels above 9.1 nmol/L, with concentrations in the range from 4.9 to 31.6 nmol/L. Neopterin levels gradually decreased during the course of COVID-19, but severe cases maintained elevated levels for a longer period. Moreover, lower levels of tryptophan and higher levels of kynurenine, indicating an increased tryptophan catabolism, were seen in the group with severe cases. Conclusions In conclusion, we found that serum neopterin levels are associated with the severity of COVID-19. Our findings suggest that neopterin could be used as a prognostic marker, but further studies are needed to elucidate how it can be used in clinical praxis.", "doi": "10.1186/s12879-020-05671-7", "pmid": "33302893", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Research Area: Biomarkers and systems immunology": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-10-30T11:40:52.446Z", "modified": "2021-06-13T05:56:58.395Z"}, {"entity": "publication", "iuid": "d3008d631eca40d0be03bf85943fe585", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3008d631eca40d0be03bf85943fe585.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3008d631eca40d0be03bf85943fe585"}}, "title": "Public perceptions of multiple risks during the COVID-19 pandemic in Italy and Sweden.", "authors": [{"family": "Mondino", "given": "Elena", "initials": "E"}, {"family": "Di Baldassarre", "given": "Giuliano", "initials": "G"}, {"family": "M\u00e5rd", "given": "Johanna", "initials": "J"}, {"family": "Ridolfi", "given": "Elena", "initials": "E"}, {"family": "Rusca", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2020-12-10", "journal": {"title": "Sci Data", "issn": "2052-4463", "volume": "7", "issue": "1", "pages": "434", "issn-l": null}, "abstract": "Knowing how people perceive multiple risks is essential to the management and promotion of public health and safety. Here we present a dataset based on a survey (N = 4,154) of public risk perception in Italy and Sweden during the COVID-19 pandemic. Both countries were heavily affected by the first wave of infections in Spring 2020, but their governmental responses were very different. As such, the dataset offers unique opportunities to investigate the role of governmental responses in shaping public risk perception. In addition to epidemics, the survey considered indirect effects of COVID-19 (domestic violence, economic crises), as well as global (climate change) and local (wildfires, floods, droughts, earthquakes, terror attacks) threats. The survey examines perceived likelihoods and impacts, individual and authorities' preparedness and knowledge, and socio-demographic indicators. Hence, the resulting dataset has the potential to enable a plethora of analyses on social, cultural and institutional factors influencing the way in which people perceive risk.", "doi": "10.1038/s41597-020-00778-7", "pmid": "33303742", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41597-020-00778-7"}, {"db": "URL", "key": "https://doi.org/10.5281/zenodo.4034276", "description": "Raw dataset: perceived likelihoods and impacts, individual and authorities\u2019 preparedness and knowledge, socio-demographic characteristics (N=2,033 in Italy, N=2,121 in Sweden)"}], "notes": [], "created": "2020-12-13T07:21:54.602Z", "modified": "2021-02-26T08:47:00.220Z"}, {"entity": "publication", "iuid": "d8a6f0a2b02147618996bed9adb324bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d8a6f0a2b02147618996bed9adb324bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d8a6f0a2b02147618996bed9adb324bf"}}, "title": "Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses", "authors": [{"family": "Tampere", "given": "Marianna", "initials": "M"}, {"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Salata", "given": "Cristiano", "initials": "C"}, {"family": "Wallner", "given": "Olov", "initials": "O"}, {"family": "Koolmeister", "given": "Tobias", "initials": "T"}, {"family": "Cazares-K\u00f6rner", "given": "Armando", "initials": "A"}, {"family": "Visnes", "given": "Torkild", "initials": "T"}, {"family": "Hesselman", "given": "Maria Carmen", "initials": "MC"}, {"family": "Kunold", "given": "Elena", "initials": "E"}, {"family": "Wiita", "given": "Elisee", "initials": "E"}, {"family": "Kalder\u00e9n", "given": "Christina", "initials": "C"}, {"family": "Lightowler", "given": "Molly", "initials": "M"}, {"family": "Jemth", "given": "Ann Sofie", "initials": "AS"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J"}, {"family": "Rosenquist", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Warpman-Berglund", "given": "Ulrika", "initials": "U"}, {"family": "Helleday", "given": "Thomas", "initials": "T"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Jafari", "given": "Rozbeh", "initials": "R"}, {"family": "Puumalainen", "given": "Marjo Riitta", "initials": "MR"}], "type": "journal-article", "published": "2020-12-10", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "12", "issue": "12", "pages": "1423"}, "abstract": null, "doi": "10.3390/v12121423", "pmid": null, "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Category: Drug Discovery": null, "Category: Proteins": null}, "xrefs": [{"db": "URL", "key": "https://www.mdpi.com/1999-4915/12/12/1423/s1", "description": "Antiviral screening; Dose-response treatment of TH6744 and TH3289; List of proteins from 2D-TPP analysis in U87 cells (FDR); List of proteins from 2D-TPP analysis in U87 cells (Fold-change); Uniprot annotation of overlapping TPP-TR and 2D-TPP hits"}, {"db": "URL", "key": "https://doi.org/10.17044/scilifelab.13089023", "description": "Thermal Proteome Profiling dataset from Hazara virus infected SW13 cells"}, {"db": "URL", "key": "http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD021494", "description": "Raw mass spectrometry data were deposited in the ProteomeXchange Consortium (accession: PXD021494)"}], "notes": [], "created": "2020-12-15T10:44:22.469Z", "modified": "2021-11-18T10:43:13.213Z"}, {"entity": "publication", "iuid": "da568203ba764ebf94e393dfa8ffe7f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/da568203ba764ebf94e393dfa8ffe7f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/da568203ba764ebf94e393dfa8ffe7f9"}}, "title": "Variable sensitivity in molecular detection of SARS-CoV-2 in European Expert Laboratories: External Quality Assessment, June - July 2020.", "authors": [{"family": "Fischer", "given": "Carlo", "initials": "C"}, {"family": "M\u00f6gling", "given": "Ramona", "initials": "R"}, {"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "K\u00fchne", "given": "Arne", "initials": "A"}, {"family": "Oliveira-Filho", "given": "Edmilson F", "initials": "EF"}, {"family": "Wolff", "given": "Thorsten", "initials": "T"}, {"family": "Reiche", "given": "Janine", "initials": "J"}, {"family": "Broberg", "given": "Eeva", "initials": "E"}, {"family": "Meijer", "given": "Adam", "initials": "A"}, {"family": "Leitmeyer", "given": "Katrin", "initials": "K"}, {"family": "Drexler", "given": "Jan Felix", "initials": "JF"}, {"family": "Reusken", "given": "Chantal B E M", "initials": "CBEM"}], "type": "journal article", "published": "2020-12-09", "journal": {"title": "J Clin Microbiol", "issn": "1098-660X", "volume": null, "issue": null, "issn-l": null}, "abstract": "Objective: During the ongoing coronavirus disease 2019 (COVID-19) outbreak, robust detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a key element for clinical management and to interrupt transmission chains. We organized an external quality assessment (EQA) of molecular detection of SARS-CoV-2 for European expert laboratories.Study design: An EQA panel composed of 12 samples, containing either SARS-CoV-2 at different concentrations to evaluate sensitivity or other respiratory viruses to evaluate specificity of SARS-CoV-2 testing, was distributed to 68 laboratories in 35 countries. Specificity samples included seasonal human coronaviruses hCoV-229E, hCoV-NL63 and hCoV-OC43, as well as MERS-CoV, SARS-CoV and human influenza virus A and B.Conclusion: Sensitivity was variable among laboratories, particularly for low concentration SARS-CoV-2 samples. Results indicated that performance was mostly independent of the selection of specific extraction or PCR methods.", "doi": "10.1128/JCM.02676-20", "pmid": "33298612", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "JCM.02676-20"}], "notes": [], "created": "2020-12-21T10:24:12.977Z", "modified": "2020-12-21T10:24:18.568Z"}, {"entity": "publication", "iuid": "7bc8cd7ed5a147eaad1edb24379e7c5a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7bc8cd7ed5a147eaad1edb24379e7c5a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7bc8cd7ed5a147eaad1edb24379e7c5a"}}, "title": "SARS-CoV-2 Spike protein binds to bacterial lipopolysaccharide and boosts proinflammatory activity.", "authors": [{"family": "Petruk", "given": "Ganna", "initials": "G"}, {"family": "Puthia", "given": "Manoj", "initials": "M"}, {"family": "Petrlova", "given": "Jitka", "initials": "J"}, {"family": "Samsudin", "given": "Firdaus", "initials": "F"}, {"family": "Str\u00f6mdahl", "given": "Ann-Charlotte", "initials": "A"}, {"family": "Cerps", "given": "Samuel", "initials": "S"}, {"family": "Uller", "given": "Lena", "initials": "L"}, {"family": "Kjellstr\u00f6m", "given": "Sven", "initials": "S"}, {"family": "Bond", "given": "Peter J", "initials": "PJ"}, {"family": "Schmidtchen", "given": "Artur", "initials": "A"}], "type": "journal article", "published": "2020-12-09", "journal": {"title": "J Mol Cell Biol", "issn": "1759-4685", "issn-l": null, "volume": "12", "issue": "12", "pages": "916-932"}, "abstract": "There is a link between high lipopolysaccharide (LPS) levels in the blood and the metabolic syndrome, and metabolic syndrome predisposes patients to severe COVID-19. Here, we define an interaction between SARS-CoV-2 Spike (S) protein and LPS, leading to aggravated inflammation in vitro and in vivo. Native gel electrophoresis demonstrated that SARS-CoV-2 S protein binds to LPS. Microscale thermophoresis yielded a KD of \u223c47 nM for the interaction. Computational modeling and all-atom molecular dynamics simulations further substantiated the experimental results, identifying a main LPS binding site in SARS-CoV-2 S protein. S protein, when combined with low levels of LPS, boosted nuclear factor-kappa B (NF-\u03baB) activation in monocytic THP-1 cells and cytokine responses in human blood and peripheral blood mononuclear cells, respectively. The in vitro inflammatory response was further validated by employing NF-\u03baB reporter mice and in vivo bioimaging. Dynamic light scattering, transmission electron microscopy, and LPS-FITC analyses demonstrated that S protein modulated the aggregation state of LPS, providing a molecular explanation for the observed boosting effect. Taken together, our results provide an interesting molecular link between excessive inflammation during infection with SARS-CoV-2 and comorbidities involving increased levels of bacterial endotoxins.", "doi": "10.1093/jmcb/mjaa067", "pmid": "33295606", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "6028992"}], "notes": [], "created": "2020-12-10T09:10:19.161Z", "modified": "2021-04-23T14:37:52.421Z"}, {"entity": "publication", "iuid": "cc5b5a5b202d4a13a3a6e430695e4976", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc5b5a5b202d4a13a3a6e430695e4976.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc5b5a5b202d4a13a3a6e430695e4976"}}, "title": "Positive correlation between long term emission of several air pollutants and COVID-19 deaths in Sweden", "authors": [{"family": "Helander", "given": "Lars", "initials": "L"}], "type": "posted-content", "published": "2020-12-09", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.05.20244418", "pmid": null, "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-03-25T14:03:24.020Z", "modified": "2021-03-29T10:10:22.147Z"}, {"entity": "publication", "iuid": "d4e70020cceb46fab1a1a5d44e34e9ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4e70020cceb46fab1a1a5d44e34e9ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4e70020cceb46fab1a1a5d44e34e9ae"}}, "title": "Public health emergencies of international concern: a historic overview.", "authors": [{"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Osman", "given": "Sarah", "initials": "S"}], "type": "journal article", "published": "2020-12-08", "journal": {"title": "J Travel Med", "issn": "1708-8305", "volume": "27", "issue": "8", "issn-l": null}, "abstract": "The International Health Regulations (IHR) have been the governing framework for global health security since 2007. Declaring public health emergencies of international concern (PHEIC) is a cornerstone of the IHR. Here we review how PHEIC are formally declared, the diseases for which such declarations have been made from 2007 until 2020 and justifications for such declarations.\n\nSix events were declared PHEIC between 2007 and 2020: the 2009 H1N1 influenza pandemic, Ebola (West African outbreak 2013-2015, outbreak in Democratic Republic of Congo 2018-2020), poliomyelitis (2014 to present), Zika (2016) and COVID-19 (2020 to present). Poliomyelitis is the longest PHEIC. Zika was the first PHEIC for an arboviral disease. For several other emerging diseases a PHEIC was not declared despite the fact that the public health impact of the event was considered serious and associated with potential for international spread.\n\nThe binary nature of a PHEIC declaration is often not helpful for events where a tiered or graded approach is needed. The strength of PHEIC declarations is the ability to rapidly mobilize international coordination, streamline funding and accelerate the advancement of the development of vaccines, therapeutics and diagnostics under emergency use authorization. The ultimate purpose of such declaration is to catalyse timely evidence-based action, to limit the public health and societal impacts of emerging and re-emerging disease risks while preventing unwarranted travel and trade restrictions.", "doi": "10.1093/jtm/taaa227", "pmid": "33284964", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "6025447"}], "notes": [], "created": "2020-12-10T09:16:43.061Z", "modified": "2021-01-22T09:25:37.994Z"}, {"entity": "publication", "iuid": "a5bc184f74d94abaaf2126638eb17ffa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a5bc184f74d94abaaf2126638eb17ffa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a5bc184f74d94abaaf2126638eb17ffa"}}, "title": "Protective role of tacrolimus, deleterious role of age and comorbidities in liver transplant recipients with Covid-19: results from the ELITA/ELTR multi-center European study.", "authors": [{"family": "Belli", "given": "Luca S", "initials": "LS"}, {"family": "Fondevila", "given": "Constantino", "initials": "C"}, {"family": "Cortesi", "given": "Paolo A", "initials": "PA"}, {"family": "Conti", "given": "Sara", "initials": "S"}, {"family": "Karam", "given": "Vincent", "initials": "V"}, {"family": "Adam", "given": "Rene", "initials": "R"}, {"family": "Coilly", "given": "Audrey", "initials": "A"}, {"family": "Ericzon", "given": "Bo Goran", "initials": "BG"}, {"family": "Loinaz", "given": "Carmelo", "initials": "C"}, {"family": "Cuervas-Mons", "given": "Valentin", "initials": "V"}, {"family": "Zambelli", "given": "Marco", "initials": "M"}, {"family": "Llado", "given": "Laura", "initials": "L"}, {"family": "Diaz", "given": "Fernando", "initials": "F"}, {"family": "Invernizzi", "given": "Federica", "initials": "F"}, {"family": "Patrono", "given": "Damiano", "initials": "D"}, {"family": "Faitot", "given": "Francois", "initials": "F"}, {"family": "Bhooori", "given": "Sherrie", "initials": "S"}, {"family": "Pirenne", "given": "Jacques", "initials": "J"}, {"family": "Perricone", "given": "Giovanni", "initials": "G"}, {"family": "Magini", "given": "Giulia", "initials": "G"}, {"family": "Castells", "given": "LLuis", "initials": "L"}, {"family": "Detry", "given": "Oliver", "initials": "O"}, {"family": "Cruchaga", "given": "Pablo Mart", "initials": "PM"}, {"family": "Colmenero", "given": "Jordi", "initials": "J"}, {"family": "Berrevoet", "given": "Frederick", "initials": "F"}, {"family": "Rodriguez", "given": "Gonzalo", "initials": "G"}, {"family": "Ysebaert", "given": "Dirk", "initials": "D"}, {"family": "Radenne", "given": "Sylvie", "initials": "S"}, {"family": "Metselaar", "given": "Herold", "initials": "H"}, {"family": "Morelli", "given": "Cristina", "initials": "C"}, {"family": "De Carlis", "given": "Luciano", "initials": "L"}, {"family": "Polak", "given": "Wojciech G", "initials": "WG"}, {"family": "Duvoux", "given": "Christophe", "initials": "C"}, {"family": "all the centres contributing to the ELITA-ELTR COVID-19 Registry", "given": "", "initials": ""}], "type": "journal article", "published": "2020-12-08", "journal": {"title": "Gastroenterology", "issn": "1528-0012", "volume": null, "issue": null, "issn-l": null}, "abstract": "Despite concerns that liver transplant (LT) recipients may be at increased risk of unfavorable outcomes from COVID-19 due the high prevalence of co-morbidities, immunosuppression and ageing, a detailed analysis of their effects in large studies is lacking METHODS: Data from adult LT recipients with laboratory confirmed SARS-CoV2 infection were collected across Europe. All consecutive patients with symptoms were included in the analysis, RESULTS: Between March 1st and June 27 th2020, data from 243 adult symptomatic cases from 36 centers and 9 countries were collected. Thirty-nine (16%) were managed as outpatients while 204 (84%) required hospitalization including admission to the ICU (39/204, 19.1%). Forty-nine (20.2%) patients died after a median of 13.5 (10-23) days, respiratory failure was the major cause. After multivariable Cox regression analysis, age > 70 (HR 4.16; 95%CI 1.78-9.73) had a negative effect and tacrolimus (TAC) use (HR 0.55; 95%CI 0.31-0.99) had a positive independent effect on survival. The role of co-morbidities was strongly influenced by the dominant effect of age where comorbidities increased with the increasing age of the recipients. In a second model excluding age, both diabetes (HR 1.95; 95%CI 1.06 - 3.58) and chronic kidney disease (HR 1.97; 95%CI 1.05 - 3.67) emerged as associated with death CONCLUSIONS: Twenty-five per cent of patients requiring hospitalization for Covid-19 died, the risk being higher in patients older than 70 and with medical co-morbidities, such as impaired renal function and diabetes. Conversely, the use of TAC was associated with a better survival thus encouraging clinicians to keep TAC at the usual dose.", "doi": "10.1053/j.gastro.2020.11.045", "pmid": "33307029", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S0016-5085(20)35514-1"}], "notes": [], "created": "2020-12-13T07:08:28.389Z", "modified": "2021-02-26T08:45:03.178Z"}, {"entity": "publication", "iuid": "dd16fa9a8be04f01a74a4ac5d1cd3863", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dd16fa9a8be04f01a74a4ac5d1cd3863.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dd16fa9a8be04f01a74a4ac5d1cd3863"}}, "title": "No impact of cancer and plague-relevant FPR1 polymorphisms on COVID-19.", "authors": [{"family": "Petrazzuolo", "given": "Adriana", "initials": "A"}, {"family": "Le Naour", "given": "Julie", "initials": "J"}, {"family": "Vacchelli", "given": "Erika", "initials": "E"}, {"family": "Gaussem", "given": "Pascale", "initials": "P"}, {"family": "Ellouze", "given": "Syrine", "initials": "S"}, {"family": "Jourdi", "given": "Georges", "initials": "G"}, {"family": "Solary", "given": "Eric", "initials": "E"}, {"family": "Fontenay", "given": "Michaela", "initials": "M"}, {"family": "Smadja", "given": "David M", "initials": "DM"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}], "type": "journal article", "published": "2020-12-08", "journal": {"title": "Oncoimmunology", "issn": "2162-402X", "volume": "9", "issue": "1", "pages": "1857112", "issn-l": "2162-4011"}, "abstract": "Formyl peptide receptor 1 (FPR1) is a pattern-recognition receptor that detects bacterial as well as endogenous danger-associated molecular patterns to trigger innate immune responses by myeloid cells. A single nucleotide polymorphism, rs867228 (allelic frequency 19-20%), in the gene coding for FPR1 accelerates the manifestation of multiple carcinomas, likely due to reduced anticancer immunosurveillance secondary to a defect in antigen presentation by dendritic cells. Another polymorphism in FPR1, rs5030880 (allelic frequency 12-13%), has been involved in the resistance to plague, correlating with the fact that FPR1 is the receptor for Yersinia pestis. Driven by the reported preclinical effects of FPR1 on lung inflammation and fibrosis, we investigated whether rs867228 or rs5030880 would affect the severity of coronavirus disease-19 (COVID-19). Data obtained on patients from two different hospitals in Paris refute the hypothesis that rs867228 or rs5030880 would affect the severity of COVID-19.", "doi": "10.1080/2162402X.2020.1857112", "pmid": "33344044", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "1857112"}, {"db": "pmc", "key": "PMC7734042"}, {"db": "URL", "key": "https://www.tandfonline.com/doi/figure/10.1080/2162402X.2020.1857112?scroll=top&needAccess=true", "description": "Allelic frequencies of FPR1 SNPs and characteristics of patient population from H\u00f4pital Cochin and H\u00f4pital Europ\u00e9en George Pompidou"}], "notes": [], "created": "2021-01-07T09:58:41.553Z", "modified": "2021-11-18T10:35:20.483Z"}, {"entity": "publication", "iuid": "6f826f3022c54f3c9bc2f1833f17a0cd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f826f3022c54f3c9bc2f1833f17a0cd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f826f3022c54f3c9bc2f1833f17a0cd"}}, "title": "Asymptomatic SARS-CoV-2 infection: Is it all about being refractile to innate immune sensing of viral spare-parts? - Clues from exotic animal reservoirs.", "authors": [{"family": "Shankar", "given": "Esaki M", "initials": "EM"}, {"family": "Che", "given": "Karlhans F", "initials": "KF"}, {"family": "Yong", "given": "Yean K", "initials": "YK"}, {"family": "Girija", "given": "A S Smiline", "initials": "ASS"}, {"family": "Velu", "given": "Vijayakumar", "initials": "V"}, {"family": "Ansari", "given": "Abdul W", "initials": "AW"}, {"family": "Larsson", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2020-12-08", "journal": {"title": "Pathog Dis", "issn": "2049-632X", "issn-l": null, "volume": "79", "issue": "1", "pages": null}, "abstract": "A vast proportion of coronavirus disease 2019 (COVID-19) individuals remain asymptomatic and can shed severe acute respiratory syndrome (SARS-CoV) type 2 virus to transmit the infection, which also explains the exponential increase in the number of COVID-19 cases globally. Furthermore, the rate of recovery rates from clinical COVID-19 in certain pockets of the globe is surprisingly high. Based on published reports and available literature, here, we speculated a few immunovirological mechanisms as to why a vast majority of individuals remain asymptomatic similar to exotic animal (bats and pangolins) reservoirs that remain refractile to disease development despite carrying a huge load of diverse insidious viral species, and whether such evolutionary advantage would unveil therapeutic strategies against human COVID-19 infection. Understanding the unique mechanisms that exotic animal species employ to achieve viral control, as well as inflammatory regulation, appears to hold key clues to the development of therapeutic versatility against COVID-19.", "doi": "10.1093/femspd/ftaa076", "pmid": "33289808", "labels": {"Funder: KAW/SciLifeLab": null, "Type: Review": null, "Research Area: Biomarkers and systems immunology": null}, "xrefs": [{"db": "pii", "key": "6027506"}], "notes": [], "created": "2020-12-10T09:14:38.546Z", "modified": "2021-06-13T05:58:21.495Z"}, {"entity": "publication", "iuid": "2e1039d1c30f4e3e969ab8ed6afe7d20", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e1039d1c30f4e3e969ab8ed6afe7d20.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e1039d1c30f4e3e969ab8ed6afe7d20"}}, "title": "Nitric oxide's physiologic effects and potential as a therapeutic agent against COVID-19.", "authors": [{"family": "Ricciardolo", "given": "Fabio Luigi Massimo", "initials": "FLM"}, {"family": "Bertolini", "given": "Francesca", "initials": "F"}, {"family": "Carriero", "given": "Vitina", "initials": "V"}, {"family": "H\u00f6gman", "given": "Marieann", "initials": "M", "orcid": "0000-0002-6392-6092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86cdb5ef5c2e48d886bc443db7f3b64e.json"}}], "type": "journal article", "published": "2020-12-05", "journal": {"title": "J Breath Res", "issn": "1752-7163", "volume": "15", "issue": "1", "pages": "014001", "issn-l": "1752-7155"}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for COVID-19 pneumonia, a pandemic that precipitates huge pressures on the world's social and economic systems. Disease severity varies among individuals. SARS-CoV-2 infection can be associated with e.g. flu-like symptoms, dyspnoea, severe interstitial pneumonia, acute respiratory distress syndrome, multiorgan dysfunction, and generalized coagulopathy. Nitric oxide (NO), is a small signal molecule that impacts pleiotropic functions in human physiology, which can be involved in the significant effects of COVID-19 infection. NO is a neurotransmitter involved in the neural olfactory processes in the central nervous system, and some infected patients have reported anosmia as a symptom. Additionally, NO is a well-known vasodilator, important coagulation mediator, anti-microbial effector and inhibitor of SARS-CoV replication. Exhaled NO is strongly related to the type-2 inflammatory response found in asthma, which has been suggested to be protective against SARS-CoV-2 infection. Several reports indicate that the use of inhaled NO has been an effective therapy during this pandemic since the ventilation-perfusion ratio in COVID-19 patients improved afterwards and they did not require mechanical ventilation. The aim of this mini-review is to summarize relevant actions of NO that could be beneficial in the treatment of COVID-19.", "doi": "10.1088/1752-7163/abc302", "pmid": "33080582", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-19T19:29:57.613Z", "modified": "2023-01-13T13:43:21.870Z"}, {"entity": "publication", "iuid": "e76a6c0b95dc43c883950fbdbb497773", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e76a6c0b95dc43c883950fbdbb497773.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e76a6c0b95dc43c883950fbdbb497773"}}, "title": "Responsible Gambling Telephone Intervention to High-Risk Gamblers by a State-Owned Gambling Operator in Sweden: Study Protocol for a Study on Effectiveness, User Satisfaction, and Acceptability.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "Franklin", "given": "Katja", "initials": "K"}, {"family": "Dahlstr\u00f6m", "given": "Maria", "initials": "M"}, {"family": "Lyckberg", "given": "Axel", "initials": "A"}], "type": "journal article", "published": "2020-12-04", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "17", "issue": "23", "issn-l": null}, "abstract": "Gambling disorder is associated with severe financial, social, and psychological consequences, but treatment-seeking rates have been described to be low. Apart from formal treatment, motivational interventions in nontreatment-seeking high-risk gamblers have been shown to be promising. However, little is known about the effectiveness and acceptability of such motivational interventions carried out by a gambling operator as part of the company's responsible gambling policies. Early experiences of such interventions are limited by the risk that gambling in individuals reached with the intervention may continue with a different gambling operator. The present study aims to evaluate effectiveness and user acceptability of a responsible gambling intervention continuously carried out by the Swedish state-owned gambling operator Svenska Spel Sport & Casino. This intervention for high-risk gamblers, identified either through substantial monetary losses or through a voluntary self-test by the gambler, includes a motivational telephone intervention aiming to encourage the gambler to set deposit limits, practice self-exclusion, or seek help. This protocol paper describes the two-tailed evaluation of this intervention: (1) A retrospective, register-based study of the effectiveness of the motivational intervention on gambling expenditures, deposit limits, and self-exclusions in comparison to control individuals not reached by the intervention, including all clients reached or attempted to be reached during September 2019-April 2020 (total n = 3626), as well as a one-to-one matched comparison of clients reached (n = 1404) and not reached; and (2) a prospective web survey study in individuals reached by the same ongoing telephone intervention practice from November 2020 (target n = 200), measuring clients' attitudes to the intervention, perceived effects of the intervention on gambling, and their self-reported gambling on all operators after the intervention.", "doi": "10.3390/ijerph17239069", "pmid": "33561040", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph17239069"}], "notes": [], "created": "2021-02-10T18:44:43.305Z", "modified": "2021-02-26T08:47:00.274Z"}, {"entity": "publication", "iuid": "1d1d051d522c4e08ae59fe3448e9558a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d1d051d522c4e08ae59fe3448e9558a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d1d051d522c4e08ae59fe3448e9558a"}}, "title": "Harnessing the Power of Social Media to Support a Professional Learning Network During the COVID-19 Pandemic.", "authors": [{"family": "Hall", "given": "Elissa", "initials": "E"}, {"family": "Kreuter", "given": "Justin D", "initials": "JD"}, {"family": "S\u00f6r\u00f6", "given": "Teresa", "initials": "T"}, {"family": "Dzara", "given": "Kristina", "initials": "K"}, {"family": "Gooding", "given": "Holly C", "initials": "HC"}], "type": "journal article", "published": "2020-12-04", "journal": {"title": "J Contin Educ Health Prof", "issn": "1554-558X", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1097/CEH.0000000000000326", "pmid": "33290300", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-10T09:13:53.850Z", "modified": "2020-12-10T09:14:04.250Z"}, {"entity": "publication", "iuid": "9ceaca5cb62245e8a1173dd1758a02d2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ceaca5cb62245e8a1173dd1758a02d2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ceaca5cb62245e8a1173dd1758a02d2"}}, "title": "Choir Singers Without Rehearsals and Concerts? A Questionnaire Study on Perceived Losses From Restricting Choral Singing During the Covid-19 Pandemic.", "authors": [{"family": "Theorell", "given": "T\u00f6res", "initials": "T"}, {"family": "Kowalski", "given": "Jan", "initials": "J"}, {"family": "Theorell", "given": "Ann Mari Lind", "initials": "AML"}, {"family": "Horwitz", "given": "Eva Bojner", "initials": "EB"}], "type": "journal article", "published": "2020-12-04", "journal": {"title": "J Voice", "issn": "1873-4588", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Choir singing is an activity that engages individuals all over the world with a broad demographic representation. Both qualitative and quantitative studies have examined the benefits of the activity but very few have examined the effects when someone loses access to it and stops singing.\r\n\r\nExamining the governmental and organisational responses precipitated by the COVID-19 pandemic, we asked what happens when a choir singer loses all of their routines associated with regular participation in choir singing.\r\n\r\nOne national choir organization in Sweden (n = 3163) and one in Norway (n = 1881) were approached with a short survey. This comprised questions relating to the issue \"what do you as a choir singer misses the most?\" Each participant was asked to rate the importance of a number of elements that pertain to the experience of choir singing.\r\n\r\nThe social aspect of singing emerged as having the strongest weight in terms of perceived loss that is, it was the element that the participants missed the most. Professional singers report that they miss the aesthetic experiences, flow, and all the physical aspects (physical training, voice training, and breathing training) to a greater degree as compared to reports from the amateurs. The importance of aesthetic experiences and physical components appeared to rise with increasing number of years that an individual had engaged with choir singing.\r\n\r\nIn the Scandinavian setting, the social aspect has a stronger weight than the other components and this seemed to be more significant in Norway compared to Sweden.", "doi": "10.1016/j.jvoice.2020.11.006", "pmid": "33288380", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0892-1997(20)30422-7"}], "notes": [], "created": "2020-12-10T09:15:41.012Z", "modified": "2022-11-22T05:49:56.111Z"}, {"entity": "publication", "iuid": "ee547b2d04a741ffa826a9ee92b9593c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee547b2d04a741ffa826a9ee92b9593c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee547b2d04a741ffa826a9ee92b9593c"}}, "title": "A Novel Approach to Hematology Testing at the Point of Care.", "authors": [{"family": "Bransky", "given": "Avishay", "initials": "A"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Aardal", "given": "Elisabeth", "initials": "E"}, {"family": "Ben-Yosef", "given": "Yaara", "initials": "Y"}, {"family": "Christenson", "given": "Robert H", "initials": "RH"}], "type": "journal article", "published": "2020-12-04", "journal": {"title": "J Appl Lab Med", "issn": "2576-9456", "volume": null, "issue": null, "issn-l": null}, "abstract": "The need for rapid point-of-care (POC) diagnostics is now becoming more evident due to the increasing need for timely results and improvement in healthcare service. With the recent COVID-19 pandemic outbreak, POC has become critical in managing the spread of disease. Applicable diagnostics should be readily deployable, easy to use, portable, and accurate so that they fit mobile laboratories, pop-up treatment centers, field hospitals, secluded wards within hospitals, or remote regions, and can be operated by staff with minimal training. Complete blood count (CBC), however, has not been available at the POC in a simple-to-use device until recently. The HemoScreen, which was recently cleared by the FDA for POC use, is a miniature, easy-to-use instrument that uses disposable cartridges and may fill this gap.\n\nThe HemoScreen's analysis method, in contrast to standard laboratory analyzers, is based on machine vision (image-based analysis) and artificial intelligence (AI). We discuss the different methods currently used and compare their results to the vision-based one. The HemoScreen is found to correlate well to laser and impedance-based methods while emphasis is given to mean cell volume (MCV), mean cell hemoglobin (MCH), and platelets (PLT) that demonstrate better correlation when the vision-based method is compared to itself due to the essential differences between the underlying technologies.\n\nThe HemoScreen analyzer demonstrates lab equivalent performance, tested at different clinical settings and sample characteristics, and might outperform standard techniques in the presence of certain interferences. This new approach to hematology testing has great potential to improve quality of care in a variety of settings.", "doi": "10.1093/jalm/jfaa186", "pmid": "33274357", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "6020101"}], "notes": [], "created": "2020-12-06T07:07:57.964Z", "modified": "2021-02-26T08:46:13.585Z"}, {"entity": "publication", "iuid": "ae653e3642a04dc0b8c1b2550cb03a7d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ae653e3642a04dc0b8c1b2550cb03a7d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ae653e3642a04dc0b8c1b2550cb03a7d"}}, "title": "Risk perception and determinants in small- and medium-sized agri-food enterprises amidst the COVID-19 pandemic: Evidence from Egypt.", "authors": [{"family": "Abu Hatab", "given": "Assem", "initials": "A"}, {"family": "Lagerkvist", "given": "Carl-Johan", "initials": "CJ"}, {"family": "Esmat", "given": "Abourehab", "initials": "A"}], "type": "journal article", "published": "2020-12-03", "journal": {"title": "Agribusiness (N Y N Y)", "issn": "1520-6297", "volume": null, "issue": null, "issn-l": null}, "abstract": "The coronavirus disease-2019 (COVID-19) pandemic has disrupted many activities along agri-food supply chains in developing countries and posed unprecedented challenges in particular to small and medium agri-food enterprises (SMEs). Drawing on a survey of 166 Egyptian agri-food SMEs, this study investigates differences in- and determinants of COVID-19 business risk perception among these enterprises. The empirical results showed that risk perception was highly asymmetric across geographical regions. Enterprises with longer cash flow coverage periods and higher values of total assets perceived significantly lower risk levels, as cash and assets functioned as a buffer against the impact of COVID-19. The findings of the study imply that the \"just-in-time\" approach and the absence of a proactive and preventative stance to risk management reduced the resilience of agri-food SMEs to the risks presented by the pandemic. Generally, enterprises that operate both in domestic and export markets perceived lower COVID-19 risks. Finally, the main export destination to which the surveyed enterprises export was a significant determinant of their risk perception. These findings could be useful to managers of agri-food businesses in terms of better understanding of risks and promotion of risk management practices. More so, they can help design effective policy interventions to mitigate the impacts of the pandemic on Egyptian agri-food SMEs and build up their resilience to future pandemics and shocks.", "doi": "10.1002/agr.21676", "pmid": "33362335", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "AGR21676"}, {"db": "pmc", "key": "PMC7753412"}], "notes": [], "created": "2021-01-07T13:40:07.426Z", "modified": "2021-01-10T17:25:27.745Z"}, {"entity": "publication", "iuid": "7a0e1b89eac4430dbb65390fb3a90d76", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a0e1b89eac4430dbb65390fb3a90d76.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a0e1b89eac4430dbb65390fb3a90d76"}}, "title": "Patients With COVID-19 Have Elevated Levels of Circulating Extracellular Vesicle Tissue Factor Activity That Is Associated With Severity and Mortality.", "authors": [{"family": "Rosell", "given": "Axel", "initials": "A"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "von Meijenfeldt", "given": "Fien", "initials": "F"}, {"family": "Hisada", "given": "Yohei", "initials": "Y"}, {"family": "Aguilera", "given": "Katherina", "initials": "K"}, {"family": "Grover", "given": "Steven P", "initials": "SP"}, {"family": "Lisman", "given": "Ton", "initials": "T"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2020-12-03", "journal": {"title": "Arterioscler Thromb Vasc Biol", "issn": "1524-4636", "issn-l": null, "volume": "41", "issue": "2", "pages": "ATVBAHA120315547"}, "abstract": "Patients with coronavirus disease 2019 (COVID-19) have a high rate of thrombosis. We hypothesized that severe acute respiratory syndrome coronavirus 2 leads to induction of TF (tissue factor) expression and increased levels of circulating TF-positive extracellular vesicles (EV) that may drive thrombosis. Approach and Results: We measured levels of plasma EV TF activity in 100 patients with COVID-19 with moderate and severe disease and 28 healthy controls. Levels of EV TF activity were significantly higher in patients with COVID-19 compared with controls. In addition, levels of EV TF activity were associated with disease severity and mortality. Finally, levels of EV TF activity correlated with several plasma markers, including D-dimer, which has been shown to be associated with thrombosis in patients with COVID-19.\r\n\r\nOur results indicate that severe acute respiratory syndrome coronavirus 2 infection induces the release of TF-positive EVs into the circulation that are likely to contribute to thrombosis in patients with COVID-19. EV TF activity was also associated with severity and mortality.", "doi": "10.1161/ATVBAHA.120.315547", "pmid": "33267656", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-09T06:14:18.210Z", "modified": "2021-06-13T06:02:55.694Z"}, {"entity": "publication", "iuid": "76d13794cf40457aae8704e08f7676e0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76d13794cf40457aae8704e08f7676e0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76d13794cf40457aae8704e08f7676e0"}}, "title": "Helmet continuous positive airway pressure versus high-flow nasal cannula in COVID-19: a pragmatic randomised clinical trial (COVID HELMET).", "authors": [{"family": "Tverring", "given": "Jonas", "initials": "J"}, {"family": "\u00c5kesson", "given": "Anna", "initials": "A"}, {"family": "Nielsen", "given": "Niklas", "initials": "N"}], "type": "journal article", "published": "2020-12-03", "journal": {"title": "Trials", "issn": "1745-6215", "volume": "21", "issue": "1", "pages": "994", "issn-l": null}, "abstract": "Patients with COVID-19 and hypoxaemia despite conventional low-flow oxygen therapy are often treated with high-flow nasal cannula (HFNC) in line with international guidelines. Oxygen delivery by helmet continuous positive airway pressure (CPAP) is a feasible option that enables a higher positive end-expiratory pressure (PEEP) and may theoretically reduce the need for intubation compared to HFNC but direct comparative evidence is lacking.\n\nWe plan to perform an investigator-initiated, pragmatic, randomised trial at an intermediate-level COVID-19 cohort ward in Helsingborg Hospital, southern Sweden. We have estimated a required sample size of 120 patients randomised 1:1 to HFNC or Helmet CPAP to achieve 90% power to detect superiority at a 0.05 significance level regarding the primary outcome of ventilator free days (VFD) within 28 days using a Mann-Whitney U test. Patient recruitment is planned to being June 2020 and be completed in the first half of 2021.\n\nWe hypothesise that the use of Helmet CPAP will reduce the need for invasive mechanical ventilation compared to the use of HFNC without having a negative effect on survival. This could have important implications during the current COVID-19 epidemic.\n\nClinicalTrials.gov NCT04395807 . Registered on 20 May 2020.", "doi": "10.1186/s13063-020-04863-5", "pmid": "33272319", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13063-020-04863-5"}, {"db": "ClinicalTrials.gov", "key": "NCT04395807"}], "notes": [], "created": "2020-12-06T07:08:35.572Z", "modified": "2021-02-26T08:46:13.272Z"}, {"entity": "publication", "iuid": "d24497021abf4097b4a19066fdd7cdb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d24497021abf4097b4a19066fdd7cdb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d24497021abf4097b4a19066fdd7cdb1"}}, "title": "Clinical characteristics of SARS-CoV-2 infection in children with cystic fibrosis: An international observational study.", "authors": [{"family": "Bain", "given": "Robert", "initials": "R"}, {"family": "Cosgriff", "given": "Rebecca", "initials": "R"}, {"family": "Zampoli", "given": "Marco", "initials": "M"}, {"family": "Elbert", "given": "Alexander", "initials": "A"}, {"family": "Burgel", "given": "Pierre-R\u00e9gis", "initials": "PR"}, {"family": "Carr", "given": "Siobh\u00e1n B", "initials": "SB"}, {"family": "Casta\u00f1os", "given": "Claudio", "initials": "C"}, {"family": "Colombo", "given": "Carla", "initials": "C"}, {"family": "Corvol", "given": "Harriet", "initials": "H"}, {"family": "Faro", "given": "Albert", "initials": "A"}, {"family": "Goss", "given": "Christopher H", "initials": "CH"}, {"family": "Gutierrez", "given": "Hector", "initials": "H"}, {"family": "Jung", "given": "Andreas", "initials": "A"}, {"family": "Kashirskaya", "given": "Nataliya", "initials": "N"}, {"family": "Marshall", "given": "Bruce C", "initials": "BC"}, {"family": "Melo", "given": "Joel", "initials": "J"}, {"family": "Mondejar-Lopez", "given": "Pedro", "initials": "P"}, {"family": "de Monestrol", "given": "Isabelle", "initials": "I"}, {"family": "Naehrlich", "given": "Lutz", "initials": "L"}, {"family": "Pastor-Vivero", "given": "Maria Dolores", "initials": "MD"}, {"family": "Rizvi", "given": "Samar", "initials": "S"}, {"family": "Filho", "given": "Luiz Vicente Ribeiro Ferreira da Silva", "initials": "LVRFDS"}, {"family": "Brownlee", "given": "Keith G", "initials": "KG"}, {"family": "Haq", "given": "Iram J", "initials": "IJ"}, {"family": "Brodlie", "given": "Malcolm", "initials": "M"}], "type": "journal article", "published": "2020-12-03", "journal": {"title": "J Cyst Fibros", "issn": "1873-5010", "volume": null, "issue": null, "issn-l": null}, "abstract": "The presence of co-morbidities, including underlying respiratory problems, has been identified as a risk factor for severe COVID-19 disease. Information on the clinical course of SARS-CoV-2 infection in children with cystic fibrosis (CF) is limited, yet vital to provide accurate advice for children with CF, their families, caregivers and clinical teams.\n\nCases of SARS-CoV-2 infection in children with CF aged less than 18 years were collated by the CF Registry Global Harmonization Group across 13 countries between 1 February and 7 August 2020.\n\nData on 105 children were collated and analysed. Median age of cases was ten years (interquartile range 6-15), 54% were male and median percentage predicted forced expiratory volume in one second was 94% (interquartile range 79-104). The majority (71%) of children were managed in the community during their COVID-19 illness. Out of 24 children admitted to hospital, six required supplementary oxygen and two non-invasive ventilation. Around half were prescribed antibiotics, five children received antiviral treatments, four azithromycin and one additional corticosteroids. Children that were hospitalised had lower lung function and reduced body mass index Z-scores. One child died six weeks after testing positive for SARS-CoV-2 following a deterioration that was not attributed to COVID-19 disease.\n\nSARS-CoV-2 infection in children with CF is usually associated with a mild illness in those who do not have pre-existing severe lung disease.", "doi": "10.1016/j.jcf.2020.11.021", "pmid": "33309057", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1569-1993(20)30931-0"}, {"db": "pmc", "key": "PMC7713571"}], "notes": [], "created": "2020-12-21T10:19:07.648Z", "modified": "2021-02-26T08:47:00.215Z"}, {"entity": "publication", "iuid": "4e5914a83e6b48158f9a6b16ce45f216", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4e5914a83e6b48158f9a6b16ce45f216.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4e5914a83e6b48158f9a6b16ce45f216"}}, "title": "COVID-19 misinformation: Mere harmless delusions or much more? A knowledge and attitude cross-sectional study among the general public residing in Jordan.", "authors": [{"family": "Sallam", "given": "Malik", "initials": "M"}, {"family": "Dababseh", "given": "Deema", "initials": "D"}, {"family": "Yaseen", "given": "Alaa", "initials": "A"}, {"family": "Al-Haidar", "given": "Ayat", "initials": "A"}, {"family": "Taim", "given": "Duaa", "initials": "D"}, {"family": "Eid", "given": "Huda", "initials": "H"}, {"family": "Ababneh", "given": "Nidaa A", "initials": "NA"}, {"family": "Bakri", "given": "Faris G", "initials": "FG"}, {"family": "Mahafzah", "given": "Azmi", "initials": "A"}], "type": "journal article", "published": "2020-12-03", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "15", "issue": "12", "pages": "e0243264"}, "abstract": "Since the emergence of the recent coronavirus disease 2019 (COVID-19) and its spread as a pandemic, media was teeming with misinformation that led to psychologic, social and economic consequences among the global public. Probing knowledge and anxiety regarding this novel infectious disease is necessary to identify gaps in knowledge and sources of misinformation which can help public health efforts to design and implement more focused interventional measures. The aim of this study was to evaluate the knowledge, attitude and effects of misinformation about COVID-19 on anxiety level among the general public residing in Jordan. This cross-sectional study was conducted using an online-based questionnaire that took place in April 2020, which targeted people residing in Jordan, aged 18 and above. The questionnaire included items on the following: demographic characteristics of the participants, knowledge about COVID-19, anxiety level and misconceptions regarding the origin of the pandemic. The total number of participants included in final analysis was 3150. The study population was predominantly females (76.0%), with mean age of 31 years. The overall knowledge of COVID-19 was satisfactory. Older age, males, lower monthly income and educational levels, smoking and history of chronic disease were associated with perceiving COVID-19 as a very dangerous disease. Variables that were associated with a higher anxiety level during the pandemic included: lower monthly income and educational level, residence outside the capital (Amman) and history of smoking. Misinformation about the origin of the pandemic (being part of a conspiracy, biologic warfare and the 5G networks role) was also associated with higher anxiety levels. Social media platforms, TV and news releases were the most common sources of information about the pandemic. The study showed the potential harmful effects of misinformation on the general public and emphasized the need to meticulously deliver timely and accurate information about the pandemic to lessen the health, social and psychological impact of the disease.", "doi": "10.1371/journal.pone.0243264", "pmid": "33270783", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-21682"}], "notes": [], "created": "2020-12-06T07:09:15.849Z", "modified": "2022-11-23T09:03:19.499Z"}, {"entity": "publication", "iuid": "18eed320c23f4102b00dbb87e7e9029b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18eed320c23f4102b00dbb87e7e9029b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18eed320c23f4102b00dbb87e7e9029b"}}, "title": "The Structural Basis of Accelerated Host Cell Entry by SARS-CoV-2 \u2020.", "authors": [{"family": "Seyran", "given": "Murat", "initials": "M"}, {"family": "Takayama", "given": "Kazuo", "initials": "K"}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN"}, {"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Pal\u00f9", "given": "Giorgio", "initials": "G"}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Attrish", "given": "Diksha", "initials": "D"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA"}, {"family": "Ghosh", "given": "Shinjini", "initials": "S"}, {"family": "Pizzol", "given": "Damiano", "initials": "D"}, {"family": "Chauhan", "given": "Gaurav", "initials": "G"}, {"family": "Adadi", "given": "Parise", "initials": "P"}, {"family": "Mohamed Abd El-Aziz", "given": "Tarek", "initials": "T"}, {"family": "Soares", "given": "Antonio G", "initials": "AG"}, {"family": "Kandimalla", "given": "Ramesh", "initials": "R"}, {"family": "Tambuwala", "given": "Murtaza", "initials": "M"}, {"family": "Sarif Hassan", "given": "Sk", "initials": "S"}, {"family": "Kumar Azad", "given": "Gajendra", "initials": "G"}, {"family": "Pal Choudhury", "given": "Pabitra", "initials": "P"}, {"family": "Baetas-da-Cruz", "given": "Wagner", "initials": "W"}, {"family": "Serrano-Aroca", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "Brufsky", "given": "Adam M", "initials": "AM"}, {"family": "Uhal", "given": "Bruce D", "initials": "BD"}], "type": "journal article", "published": "2020-12-02", "journal": {"title": "FEBS J", "issn": "1742-4658", "volume": null, "issue": null, "issn-l": null}, "abstract": "Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of the pandemic coronavirus disease 2019 (COVID-19) that exhibits an overwhelming contagious capacity over other Human Coronaviruses (HCoVs). This structural snapshot describes the structural bases underlying the pandemic capacity of SARS-CoV-2 and explains its fast motion over respiratory epithelia that allow its rapid cellular entry. Based on notable viral spike (S) protein features, we propose that the flat sialic acid-binding domain at the N-terminal domain (NTD) of the S1 subunit leads to more effective first contact and interaction with the sialic acid layer over the epithelium and this, in turn, allows faster viral \"surfing\" of the epithelium and receptor scanning by SARS-CoV-2. Angiotensin-converting enzyme 2 (ACE-2) protein on the epithelial surface is the primary entry receptor for SARS-CoV-2, and protein-protein interaction assays demonstrate high-affinity binding of the S protein to ACE-2. To date, no high-frequency mutations were detected at the C-terminal domain (CTD) of the S1 subunit in the S protein, where the receptor-binding domain (RBD) is located. Tight binding to ACE-2 by a conserved viral RBD suggests the ACE2-RBD interaction is likely optimal. Moreover, the viral S subunit contains a cleavage site for furin and other proteases, which accelerates cell entry by SARS-CoV-2. The model proposed here describes a structural basis for the accelerated host cell entry by SARS-CoV-2 relative to other HCoVs, and also discusses emerging hypotheses that are likely to contribute to the development of antiviral strategies to combat the pandemic capacity of SARS-CoV-2.", "doi": "10.1111/febs.15651", "pmid": "33264497", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Proteins": null}, "xrefs": [], "notes": [], "created": "2020-12-03T08:14:27.869Z", "modified": "2021-02-26T08:47:18.753Z"}, {"entity": "publication", "iuid": "65b0f9f550b94462a14f0e75bbd3e9ed", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65b0f9f550b94462a14f0e75bbd3e9ed.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65b0f9f550b94462a14f0e75bbd3e9ed"}}, "title": "Lack of evidence of ACE2 expression and replicative infection by SARS-CoV-2 in human endothelial cells", "authors": [{"family": "McCracken", "given": "Ian", "initials": "I"}, {"family": "Saginc", "given": "Gaye", "initials": "G"}, {"family": "He", "given": "Liqun", "initials": "L"}, {"family": "Huseynov", "given": "Alik", "initials": "A"}, {"family": "Daniels", "given": "Alison", "initials": "A"}, {"family": "Fletcher", "given": "Sarah", "initials": "S"}, {"family": "Peghaire", "given": "Claire", "initials": "C"}, {"family": "Kalna", "given": "Viktoria", "initials": "V"}, {"family": "Andaloussi-M\u00e4e", "given": "Maarja", "initials": "M"}, {"family": "Muhl", "given": "Lars", "initials": "L"}, {"family": "Craig", "given": "Nicky M", "initials": "NM"}, {"family": "Griffiths", "given": "Samantha J", "initials": "SJ"}, {"family": "Haas", "given": "J\u00fcrgen G", "initials": "JG"}, {"family": "Tait-Burkard", "given": "Christine", "initials": "C"}, {"family": "Lendahl", "given": "Urban", "initials": "U"}, {"family": "Birdsey", "given": "Graeme M", "initials": "GM"}, {"family": "Betsholtz", "given": "Christer", "initials": "C"}, {"family": "Noseda", "given": "Michela", "initials": "M"}, {"family": "Baker", "given": "Andrew", "initials": "A"}, {"family": "Randi", "given": "Anna M", "initials": "AM"}], "type": "posted-content", "published": "2020-12-02", "journal": {"title": "", "issn": null, "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1101/2020.12.02.391664", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-06-10T04:18:46.697Z", "modified": "2021-06-10T04:19:16.922Z"}, {"entity": "publication", "iuid": "68f8998fb8eb43d1b66b8b9accbeedbb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68f8998fb8eb43d1b66b8b9accbeedbb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68f8998fb8eb43d1b66b8b9accbeedbb"}}, "title": "Dietary supplements during the COVID-19 pandemic: insights from 1.4M users of the COVID Symptom Study app - a longitudinal app-based community survey", "authors": [{"family": "Louca", "given": "Panayiotis", "initials": "P"}, {"family": "Murray", "given": "Benjamin", "initials": "B"}, {"family": "Klaser", "given": "K", "initials": "K"}, {"family": "Graham", "given": "MS", "initials": "M"}, {"family": "Mazidi", "given": "M", "initials": "M"}, {"family": "Leeming", "given": "ER", "initials": "E"}, {"family": "Thompson", "given": "E", "initials": "E"}, {"family": "Bowyer", "given": "R", "initials": "R"}, {"family": "Drew", "given": "DA", "initials": "D"}, {"family": "Nguyen", "given": "LH", "initials": "L"}, {"family": "Merino", "given": "J", "initials": "J"}, {"family": "Gomez", "given": "M", "initials": "M"}, {"family": "Mompeo", "given": "O", "initials": "O"}, {"family": "Costeira", "given": "R", "initials": "R"}, {"family": "Sudre", "given": "CH", "initials": "C"}, {"family": "Gibson", "given": "R", "initials": "R"}, {"family": "Steves", "given": "CJ", "initials": "C"}, {"family": "Wolf", "given": "J V", "initials": "JV"}, {"family": "Franks", "given": "PW", "initials": "P"}, {"family": "Ourselin", "given": "S", "initials": "S"}, {"family": "Chan", "given": "AT", "initials": "A"}, {"family": "Berry", "given": "SE", "initials": "S"}, {"family": "Valdes", "given": "AM", "initials": "A"}, {"family": "Calder", "given": "PC", "initials": "P"}, {"family": "Spector", "given": "TD", "initials": "T"}, {"family": "Menni", "given": "C", "initials": "C"}], "type": "posted-content", "published": "2020-12-02", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.11.27.20239087", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-02T07:31:41.833Z", "modified": "2021-03-10T15:20:35.782Z"}, {"entity": "publication", "iuid": "d10da61364bd4d2ba71ac7c1e0001a18", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d10da61364bd4d2ba71ac7c1e0001a18.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d10da61364bd4d2ba71ac7c1e0001a18"}}, "title": "Correction to: Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS.", "authors": [{"family": "Ferrando", "given": "Carlos", "initials": "C"}, {"family": "Suarez-Sipmann", "given": "Fernando", "initials": "F"}, {"family": "Mellado-Artigas", "given": "Ricard", "initials": "R"}, {"family": "Hern\u00e1ndez", "given": "Mar\u00eda", "initials": "M"}, {"family": "Gea", "given": "Alfredo", "initials": "A"}, {"family": "Arruti", "given": "Egoitz", "initials": "E"}, {"family": "Aldecoa", "given": "C\u00e9sar", "initials": "C"}, {"family": "Mart\u00ednez-Pall\u00ed", "given": "Graciela", "initials": "G"}, {"family": "Mart\u00ednez-Gonz\u00e1lez", "given": "Miguel A", "initials": "MA"}, {"family": "Slutsky", "given": "Arthur S", "initials": "AS"}, {"family": "Villar", "given": "Jes\u00fas", "initials": "J"}, {"family": "COVID-19 Spanish ICU Network", "given": "", "initials": ""}], "type": "published erratum", "published": "2020-12-02", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "volume": null, "issue": null, "issn-l": "0342-4642"}, "abstract": "The original version of this article unfortunately contained mistakes in Figures 1 and 3.", "doi": "10.1007/s00134-020-06251-8", "pmid": "33263817", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-020-06251-8"}], "notes": [], "created": "2020-12-03T08:15:09.651Z", "modified": "2020-12-03T15:45:39.142Z"}, {"entity": "publication", "iuid": "c82b76966c9f480594729958632f9b2b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c82b76966c9f480594729958632f9b2b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c82b76966c9f480594729958632f9b2b"}}, "title": "Clinical and molecular practice of European thoracic pathology laboratories during the COVID-19 pandemic. The past and the near future.", "authors": [{"family": "Hofman", "given": "P", "initials": "P"}, {"family": "Ili\u00e9", "given": "M", "initials": "M"}, {"family": "Chamorey", "given": "E", "initials": "E"}, {"family": "Brest", "given": "P", "initials": "P"}, {"family": "Schiappa", "given": "R", "initials": "R"}, {"family": "Nakache", "given": "V", "initials": "V"}, {"family": "Antoine", "given": "M", "initials": "M"}, {"family": "Barberis", "given": "M", "initials": "M"}, {"family": "Begueret", "given": "H", "initials": "H"}, {"family": "Bibeau", "given": "F", "initials": "F"}, {"family": "Bonnetaud", "given": "C", "initials": "C"}, {"family": "Bostr\u00f6m", "given": "P", "initials": "P"}, {"family": "Brousset", "given": "P", "initials": "P"}, {"family": "Bubendorf", "given": "L", "initials": "L"}, {"family": "Carvalho", "given": "L", "initials": "L"}, {"family": "Cathomas", "given": "G", "initials": "G"}, {"family": "Cazes", "given": "A", "initials": "A"}, {"family": "Chalabreysse", "given": "L", "initials": "L"}, {"family": "Chenard", "given": "M-P", "initials": "MP"}, {"family": "Copin", "given": "M-C", "initials": "MC"}, {"family": "C\u00f4t\u00e9", "given": "J-F", "initials": "JF"}, {"family": "Damotte", "given": "D", "initials": "D"}, {"family": "de Leval", "given": "L", "initials": "L"}, {"family": "Delongova", "given": "P", "initials": "P"}, {"family": "Thomas de Montpreville", "given": "V", "initials": "V"}, {"family": "de Muret", "given": "A", "initials": "A"}, {"family": "Dema", "given": "A", "initials": "A"}, {"family": "Dietmaier", "given": "W", "initials": "W"}, {"family": "Evert", "given": "M", "initials": "M"}, {"family": "Fabre", "given": "A", "initials": "A"}, {"family": "Forest", "given": "F", "initials": "F"}, {"family": "Foulet", "given": "A", "initials": "A"}, {"family": "Garcia", "given": "S", "initials": "S"}, {"family": "Garcia-Martos", "given": "M", "initials": "M"}, {"family": "Gibault", "given": "L", "initials": "L"}, {"family": "Gorkiewicz", "given": "G", "initials": "G"}, {"family": "Jonigk", "given": "D", "initials": "D"}, {"family": "Gosney", "given": "J", "initials": "J"}, {"family": "Hofman", "given": "A", "initials": "A"}, {"family": "Kern", "given": "I", "initials": "I"}, {"family": "Kerr", "given": "K", "initials": "K"}, {"family": "Kossai", "given": "M", "initials": "M"}, {"family": "Kriegsmann", "given": "M", "initials": "M"}, {"family": "Lassalle", "given": "S", "initials": "S"}, {"family": "Long-Mira", "given": "E", "initials": "E"}, {"family": "Lupo", "given": "A", "initials": "A"}, {"family": "Mamilos", "given": "A", "initials": "A"}, {"family": "Mat\u011bj", "given": "R", "initials": "R"}, {"family": "Meilleroux", "given": "J", "initials": "J"}, {"family": "Ortiz-Villal\u00f3n", "given": "C", "initials": "C"}, {"family": "Panico", "given": "L", "initials": "L"}, {"family": "Panizo", "given": "A", "initials": "A"}, {"family": "Papotti", "given": "M", "initials": "M"}, {"family": "Pauwels", "given": "P", "initials": "P"}, {"family": "Pelosi", "given": "G", "initials": "G"}, {"family": "Penault-Llorca", "given": "F", "initials": "F"}, {"family": "Pop", "given": "O", "initials": "O"}, {"family": "Pot\u00e9", "given": "N", "initials": "N"}, {"family": "Cajal", "given": "S R Y", "initials": "SRY"}, {"family": "Sabourin", "given": "J-C", "initials": "JC"}, {"family": "Salmon", "given": "I", "initials": "I"}, {"family": "Sajin", "given": "M", "initials": "M"}, {"family": "Savic-Prince", "given": "S", "initials": "S"}, {"family": "Schildhaus", "given": "H-U", "initials": "HU"}, {"family": "Schirmacher", "given": "P", "initials": "P"}, {"family": "Serre", "given": "I", "initials": "I"}, {"family": "Shaw", "given": "E", "initials": "E"}, {"family": "Sizaret", "given": "D", "initials": "D"}, {"family": "Stenzinger", "given": "A", "initials": "A"}, {"family": "Stojsic", "given": "J", "initials": "J"}, {"family": "Thunnissen", "given": "E", "initials": "E"}, {"family": "Timens", "given": "W", "initials": "W"}, {"family": "Troncone", "given": "G", "initials": "G"}, {"family": "Werlein", "given": "C", "initials": "C"}, {"family": "Wolff", "given": "H", "initials": "H"}, {"family": "Berthet", "given": "J-P", "initials": "JP"}, {"family": "Benzaquen", "given": "J", "initials": "J"}, {"family": "Marquette", "given": "C-H", "initials": "CH"}, {"family": "Hofman", "given": "V", "initials": "V"}, {"family": "Calabrese", "given": "F", "initials": "F"}], "type": "journal article", "published": "2020-12-02", "journal": {"title": "ESMO Open", "issn": "2059-7029", "volume": "6", "issue": "1", "pages": "100024", "issn-l": null}, "abstract": "This study evaluated the consequences in Europe of the COVID-19 outbreak on pathology laboratories orientated toward the diagnosis of thoracic diseases.\n\nA survey was sent to 71 pathology laboratories from 21 European countries. The questionnaire requested information concerning the organization of biosafety, the clinical and molecular pathology, the biobanking, the workload, the associated research into COVID-19, and the organization of education and training during the COVID-19 crisis, from 15 March to 31 May 2020, compared with the same period in 2019.\n\nQuestionnaires were returned from 53/71 (75%) laboratories from 18 European countries. The biosafety procedures were heterogeneous. The workload in clinical and molecular pathology decreased dramatically by 31% (range, 3%-55%) and 26% (range, 7%-62%), respectively. According to the professional category, between 28% and 41% of the staff members were not present in the laboratories but did teleworking. A total of 70% of the laboratories developed virtual meetings for the training of residents and junior pathologists. During the period of study, none of the staff members with confirmed COVID-19 became infected as a result of handling samples.\n\nThe COVID-19 pandemic has had a strong impact on most of the European pathology laboratories included in this study. Urgent implementation of several changes to the organization of most of these laboratories, notably to better harmonize biosafety procedures, was noted at the onset of the pandemic and maintained in the event of a new wave of infection occurring in Europe.", "doi": "10.1016/j.esmoop.2020.100024", "pmid": "33399086", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-07T09:59:21.979Z", "modified": "2021-02-26T08:45:48.695Z"}, {"entity": "publication", "iuid": "baaedfcf6bed471ba1aff4e643a673f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/baaedfcf6bed471ba1aff4e643a673f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/baaedfcf6bed471ba1aff4e643a673f0"}}, "title": "The association of mode of location activity and mobility with acute coronary syndrome: nationwide ecological study.", "authors": [{"family": "Mohammad", "given": "Moman A", "initials": "MA"}, {"family": "Koul", "given": "Sasha", "initials": "S"}, {"family": "Gale", "given": "Chris P", "initials": "CP"}, {"family": "Alfredsson", "given": "Joakim", "initials": "J"}, {"family": "James", "given": "Stefan", "initials": "S"}, {"family": "Fr\u00f6bert", "given": "Ole", "initials": "O"}, {"family": "Omerovic", "given": "Elmir", "initials": "E"}, {"family": "Erlinge", "given": "David", "initials": "D"}], "type": "journal article", "published": "2020-12-01", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "We aimed to study the effect of social containment mandates on ACS presentation during COVID-19 pandemic using location activity and mobility data from mobile phone map services.\r\n\r\nWe conducted a cross-sectional study using data from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) including all ACS presentations during the pandemic until May 07, 2020. Using a count regression model, we adjusted for day of the week, daily weather, and incidence of COVID-19.\r\n\r\nA 10% increase in activity around areas of residence was associated with 38% lower rates of ACS hospitalisations whereas increased activity relating to retail and recreation, grocery stores and pharmacies, workplaces as well as mode of mobility was associated with 10-20% higher rates of ACS hospitalisations.\r\n\r\nGovernment policy regarding social containment mandates has important public health implications for medical emergencies like ACS and may explain the decline in ACS presentations observed during COVID-19 pandemic.", "doi": "10.1111/joim.13206", "pmid": "33259680", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-12-03T08:16:01.869Z", "modified": "2021-02-26T08:47:00.178Z"}, {"entity": "publication", "iuid": "3e2f34a3e6064d69af05e77761d57bc9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3e2f34a3e6064d69af05e77761d57bc9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3e2f34a3e6064d69af05e77761d57bc9"}}, "title": "Nowcasting the COVID-19 pandemic in Bavaria.", "authors": [{"family": "G\u00fcnther", "given": "Felix", "initials": "F"}, {"family": "Bender", "given": "Andreas", "initials": "A"}, {"family": "Katz", "given": "Katharina", "initials": "K"}, {"family": "K\u00fcchenhoff", "given": "Helmut", "initials": "H"}, {"family": "H\u00f6hle", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2020-12-01", "journal": {"title": "Biom J", "issn": "1521-4036", "volume": null, "issue": null, "issn-l": null}, "abstract": "To assess the current dynamics of an epidemic, it is central to collect information on the daily number of newly diseased cases. This is especially important in real-time surveillance, where the aim is to gain situational awareness, for example, if cases are currently increasing or decreasing. Reporting delays between disease onset and case reporting hamper our ability to understand the dynamics of an epidemic close to now when looking at the number of daily reported cases only. Nowcasting can be used to adjust daily case counts for occurred-but-not-yet-reported events. Here, we present a novel application of nowcasting to data on the current COVID-19 pandemic in Bavaria. It is based on a hierarchical Bayesian model that considers changes in the reporting delay distribution over time and associated with the weekday of reporting. Furthermore, we present a way to estimate the effective time-varying case reproduction number based on predictions of the nowcast. The approaches are based on previously published work, that we considerably extended and adapted to the current task of nowcasting COVID-19 cases. We provide methodological details of the developed approach, illustrate results based on data of the current pandemic, and evaluate the model based on synthetic and retrospective data on COVID-19 in Bavaria. Results of our nowcasting are reported to the Bavarian health authority and published on a webpage on a daily basis (https://corona.stat.uni-muenchen.de/). Code and synthetic data for the analysis are available from https://github.com/FelixGuenther/nc_covid19_bavaria and can be used for adaption of our approach to different data. R e ( t )", "doi": "10.1002/bimj.202000112", "pmid": "33258177", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-03T08:17:03.493Z", "modified": "2021-02-26T08:46:13.061Z"}, {"entity": "publication", "iuid": "4c2735cd7177484b885331b93bacba85", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4c2735cd7177484b885331b93bacba85.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4c2735cd7177484b885331b93bacba85"}}, "title": "Modeling of the adsorption of a protein-fragment on kaolinite with potential antiviral activity.", "authors": [{"family": "Awad", "given": "Mahmoud E", "initials": "ME"}, {"family": "Borrego-S\u00e1nchez", "given": "Ana", "initials": "A"}, {"family": "Escamilla-Roa", "given": "Elizabeth", "initials": "E"}, {"family": "Hern\u00e1ndez-Laguna", "given": "Alfonso", "initials": "A"}, {"family": "Sainz-D\u00edaz", "given": "C Ignacio", "initials": "CI"}], "type": "journal article", "published": "2020-12-01", "journal": {"title": "Appl Clay Sci", "issn": "0169-1317", "issn-l": null, "volume": "199", "issue": null, "pages": "105865"}, "abstract": "This work aimed at studying the potentiality of interactions between kaolinite surfaces and a protein-fragment (350-370 amino acid units) extracted from the glycoprotein E1 in the transmembrane domain (TMD) of hepatitis C virus capsid. A computational work was performed for locating the potential electrostatic interaction sites between kaolinite aluminol and siloxane surfaces and the residues of this protein-fragment ligand, monitoring the possible conformational changes. This hydrated neutralized kaolinite/protein-fragment system was simulated by means of molecular modeling based on atomistic force fields based on empirical interatomic potentials and molecular dynamic (MD) simulations. The MD calculations indicated that the studied protein-fragment interacted with the kaolinite surfaces with an exothermic process and structural distortions were observed, particularly with the hydrophilic aluminol surface by favorable adsorption energy. The viral units isolation or trapping by the adsorption on the kaolinite nanoparticles producing structural distortion of the peptide ligands could lead to the blockage of the entry on the receptor and hence a lack of viral activity would be produced. Therefore, these findings with the proposed insights could be an useful information for the next experimental and development studies in the area of discovering inhibitors of the global challenged hepatitis and other pathogenic viruses based on the phyllosilicate surface activity. These MD studies can be extended to other viruses like the COVID-19 interacting with silicate minerals surfaces.", "doi": "10.1016/j.clay.2020.105865", "pmid": "33078035", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S0169-1317(20)30430-0"}, {"db": "pmc", "key": "PMC7556793"}], "notes": [], "created": "2020-12-01T16:57:41.658Z", "modified": "2021-02-26T08:45:25.864Z"}, {"entity": "publication", "iuid": "447cc7afc9f745eba4a64bd311f4a71e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/447cc7afc9f745eba4a64bd311f4a71e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/447cc7afc9f745eba4a64bd311f4a71e"}}, "title": "Impact of SARS-CoV-2 Pandemic on Patients with Primary Immunodeficiency.", "authors": [{"family": "Delavari", "given": "Samaneh", "initials": "S"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Abolnezhadian", "given": "Farhad", "initials": "F"}, {"family": "Babaha", "given": "Fateme", "initials": "F"}, {"family": "Iranparast", "given": "Sara", "initials": "S"}, {"family": "Ahanchian", "given": "Hamid", "initials": "H"}, {"family": "Moazzen", "given": "Nasrin", "initials": "N"}, {"family": "Nabavi", "given": "Mohammad", "initials": "M"}, {"family": "Arshi", "given": "Saba", "initials": "S"}, {"family": "Fallahpour", "given": "Morteza", "initials": "M"}, {"family": "Bemanian", "given": "Mohammad Hassan", "initials": "MH"}, {"family": "Shokri", "given": "Sima", "initials": "S"}, {"family": "Momen", "given": "Tooba", "initials": "T"}, {"family": "Sadeghi-Shabestari", "given": "Mahnaz", "initials": "M"}, {"family": "Molatefi", "given": "Rasol", "initials": "R"}, {"family": "Shirkani", "given": "Afshin", "initials": "A"}, {"family": "Vosughimotlagh", "given": "Ahmad", "initials": "A"}, {"family": "Safarirad", "given": "Molood", "initials": "M"}, {"family": "Sharifzadeh", "given": "Meisam", "initials": "M"}, {"family": "Pashangzadeh", "given": "Salar", "initials": "S"}, {"family": "Salami", "given": "Fereshte", "initials": "F"}, {"family": "Shirmast", "given": "Paniz", "initials": "P"}, {"family": "Rezaei", "given": "Arezou", "initials": "A"}, {"family": "Moeini Shad", "given": "Tannaz", "initials": "T"}, {"family": "Mohraz", "given": "Minoo", "initials": "M"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Yazdani", "given": "Reza", "initials": "R"}, {"family": "Aghamohamamdi", "given": "Asghar", "initials": "A"}], "type": "journal article", "published": "2020-12-01", "journal": {"title": "J Clin Immunol", "issn": "1573-2592", "issn-l": "0271-9142", "volume": null, "issue": null, "pages": null}, "abstract": "Although it is estimated that COVID-19 life-threatening conditions may be diagnosed in less than 1:1000 infected individuals below the age of 50, but the real impact of this pandemic on pediatric patients with different types of primary immunodeficiency (PID) is not elucidated. The current prospective study on a national registry of PID patients showed that with only 1.23 folds higher incidence of infections, these patients present a 10-folds higher mortality rate compared to population mainly in patients with combined immunodeficiency and immune dysregulation. Therefore, further management modalities against COVID-19 should be considered to improve the survival rate in these two PID entities using hematopoietic stem cell transplantation and immunomodulatory agents.", "doi": "10.1007/s10875-020-00928-x", "pmid": "33263173", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10875-020-00928-x"}, {"db": "URL", "key": "https://static-content.springer.com/esm/art%3A10.1007%2Fs10875-020-00928-x/MediaObjects/10875_2020_928_MOESM1_ESM.docx", "description": "General laboratory tests, immunologic investigation, computed tomographies of the chest of 17 primary immunodeficient patients infected with COVID-19"}], "notes": [], "created": "2020-12-03T15:43:43.540Z", "modified": "2021-02-26T08:46:59.930Z"}, {"entity": "publication", "iuid": "7c56f4ea33f149498351b25ed3576255", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7c56f4ea33f149498351b25ed3576255.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7c56f4ea33f149498351b25ed3576255"}}, "title": "Guidelines for accurate genotyping of SARS-CoV-2 using amplicon-based sequencing of clinical samples", "authors": [{"family": "Kubik", "given": "Slawomir", "initials": "S"}, {"family": "Marques", "given": "Ana Claudia", "initials": "AC"}, {"family": "Xing", "given": "Xiaobin", "initials": "X"}, {"family": "Silvery", "given": "Janine", "initials": "J"}, {"family": "Bertelli", "given": "Claire", "initials": "C"}, {"family": "De Maio", "given": "Flavio", "initials": "F"}, {"family": "Pournaras", "given": "Spyros", "initials": "S"}, {"family": "Burr", "given": "Tom", "initials": "T"}, {"family": "Duffourd", "given": "Yannis", "initials": "Y"}, {"family": "Siemens", "given": "Helena", "initials": "H"}, {"family": "Alloui", "given": "Chakib", "initials": "C"}, {"family": "Song", "given": "Lin", "initials": "L"}, {"family": "Wenger", "given": "Yvan", "initials": "Y"}, {"family": "Saitta", "given": "Alexandra", "initials": "A"}, {"family": "Macheret", "given": "Morgane", "initials": "M"}, {"family": "Smith", "given": "Ewan W", "initials": "EW"}, {"family": "Menu", "given": "Philippe", "initials": "P"}, {"family": "Brayer", "given": "Marion", "initials": "M"}, {"family": "Steinmetz", "given": "Lars M", "initials": "LM"}, {"family": "Si-Mohammed", "given": "Ali", "initials": "A"}, {"family": "Chuisseu", "given": "Josiane", "initials": "J"}, {"family": "Stevens", "given": "Richard", "initials": "R"}, {"family": "Constantoulakis", "given": "Pantelis", "initials": "P"}, {"family": "Sali", "given": "Michela", "initials": "M"}, {"family": "Greub", "given": "Gilbert", "initials": "G"}, {"family": "Tiemann", "given": "Carsten", "initials": "C"}, {"family": "Pelechano", "given": "Vicent", "initials": "V"}, {"family": "Willig", "given": "Adrian", "initials": "A"}, {"family": "Xu", "given": "Zhenyu", "initials": "Z"}], "type": "posted-content", "published": "2020-12-01", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.01.405738", "pmid": null, "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-20T06:32:09.512Z", "modified": "2021-02-26T08:46:13.311Z"}, {"entity": "publication", "iuid": "477c635341c54c83bea977ad9798e940", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/477c635341c54c83bea977ad9798e940.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/477c635341c54c83bea977ad9798e940"}}, "title": "Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science.", "authors": [{"family": "Evans", "given": "Paul C", "initials": "PC"}, {"family": "Rainger", "given": "G Ed", "initials": "GE"}, {"family": "Mason", "given": "Justin C", "initials": "JC"}, {"family": "Guzik", "given": "Tomasz J", "initials": "TJ"}, {"family": "Osto", "given": "Elena", "initials": "E"}, {"family": "Stamataki", "given": "Zania", "initials": "Z"}, {"family": "Neil", "given": "Desley", "initials": "D"}, {"family": "Hoefer", "given": "Imo E", "initials": "IE"}, {"family": "Fragiadaki", "given": "Maria", "initials": "M"}, {"family": "Waltenberger", "given": "Johannes", "initials": "J"}, {"family": "Weber", "given": "Christian", "initials": "C"}, {"family": "Bochaton-Piallat", "given": "Marie-Luce", "initials": "ML"}, {"family": "B\u00e4ck", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2020-12-01", "journal": {"title": "Cardiovasc Res", "issn": "1755-3245", "volume": "116", "issue": "14", "pages": "2177-2184", "issn-l": null}, "abstract": "The COVID-19 pandemic is an unprecedented healthcare emergency causing mortality and illness across the world. Although primarily affecting the lungs, the SARS-CoV-2 virus also affects the cardiovascular system. In addition to cardiac effects, e.g. myocarditis, arrhythmias, and myocardial damage, the vasculature is affected in COVID-19, both directly by the SARS-CoV-2 virus, and indirectly as a result of a systemic inflammatory cytokine storm. This includes the role of the vascular endothelium in the recruitment of inflammatory leucocytes where they contribute to tissue damage and cytokine release, which are key drivers of acute respiratory distress syndrome (ARDS), in disseminated intravascular coagulation, and cardiovascular complications in COVID-19. There is also evidence linking endothelial cells (ECs) to SARS-CoV-2 infection including: (i) the expression and function of its receptor angiotensin-converting enzyme 2 (ACE2) in the vasculature; (ii) the prevalence of a Kawasaki disease-like syndrome (vasculitis) in COVID-19; and (iii) evidence of EC infection with SARS-CoV-2 in patients with fatal COVID-19. Here, the Working Group on Atherosclerosis and Vascular Biology together with the Council of Basic Cardiovascular Science of the European Society of Cardiology provide a Position Statement on the importance of the endothelium in the underlying pathophysiology behind the clinical presentation in COVID-19 and identify key questions for future research to address. We propose that endothelial biomarkers and tests of function (e.g. flow-mediated dilatation) should be evaluated for their usefulness in the risk stratification of COVID-19 patients. A better understanding of the effects of SARS-CoV-2 on endothelial biology in both the micro- and macrovasculature is required, and endothelial function testing should be considered in the follow-up of convalescent COVID-19 patients for early detection of long-term cardiovascular complications.", "doi": "10.1093/cvr/cvaa230", "pmid": "32750108", "labels": {"Type: Review": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7454368"}, {"db": "pii", "key": "5880580"}], "notes": [], "created": "2020-12-07T15:56:02.856Z", "modified": "2023-07-13T11:29:37.533Z"}, {"entity": "publication", "iuid": "a087f8d635b14ca6b9b1369168d27799", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a087f8d635b14ca6b9b1369168d27799.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a087f8d635b14ca6b9b1369168d27799"}}, "title": "Direct oral anticoagulant use and risk of severe COVID-19.", "authors": [{"family": "Flam", "given": "Benjamin", "initials": "B"}, {"family": "Wintzell", "given": "Viktor", "initials": "V"}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}, {"family": "Pasternak", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2020-12-01", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Hypercoagulability and thromboembolism are prominent features of severe COVID-19, and ongoing anticoagulant use might be protective.\r\n\r\nWe conducted a nationwide register-based cohort study in Sweden, February through May, 2020, to assess whether ongoing direct oral anticoagulant (DOAC) use was associated with reduced risk of hospital admission for laboratory-confirmed COVID-19, or a composite of intensive care unit (ICU) admission or death due to laboratory-confirmed COVID-19.\r\n\r\nDOAC use (n=103 703) was not associated with reduced risk of hospital admission for COVID-19 (adjusted hazard ratio [aHR] [95% confidence interval] 1.00 [0.75-1.33] vs. non-use atrial fibrillation comparator [n=36 875]; and aHR 0.94 [0.80-1.10] vs. non-use cardiovascular disease comparator [n=355 699]), or ICU admission or death due to COVID-19 (aHRs 0.76 [0.51-1.12], and 0.90 [0.71-1.15], respectively).\r\n\r\nOngoing DOAC use was not associated with reduced risk of severe COVID-19, indicating that prognosis would not be modified by early outpatient DOAC initiation.", "doi": "10.1111/joim.13205", "pmid": "33258156", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-03T08:17:34.751Z", "modified": "2021-02-26T08:45:48.532Z"}, {"entity": "publication", "iuid": "00ef148f8d674870a00321fd8e20f2a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/00ef148f8d674870a00321fd8e20f2a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/00ef148f8d674870a00321fd8e20f2a4"}}, "title": "Who safeguards pregnant women's autonomy during the COVID-19 pandemic?", "authors": [{"family": "Linden", "given": "Karolina", "initials": "K"}, {"family": "Maimburg", "given": "Rikke Damkj\u00e6r", "initials": "RD"}], "type": "editorial", "published": "2020-12-00", "journal": {"title": "Sex Reprod Healthc", "issn": "1877-5764", "volume": "26", "issue": null, "pages": "100556", "issn-l": null}, "abstract": null, "doi": "10.1016/j.srhc.2020.100556", "pmid": "33010666", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1877-5756(20)30194-4"}, {"db": "pmc", "key": "PMC7513889"}], "notes": [], "created": "2020-12-03T08:53:50.819Z", "modified": "2020-12-03T08:53:50.842Z"}, {"entity": "publication", "iuid": "261224bff6264269933daf9333f0b375", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/261224bff6264269933daf9333f0b375.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/261224bff6264269933daf9333f0b375"}}, "title": "Transitioning from face-to-face treatment to iCBT for youths in primary care - therapists' attitudes and experiences.", "authors": [{"family": "Weineland", "given": "Sandra", "initials": "S"}, {"family": "Ribbeg\u00e5rdh", "given": "Rasmus", "initials": "R"}, {"family": "Kivi", "given": "Marie", "initials": "M"}, {"family": "Bygdell", "given": "Andreas", "initials": "A"}, {"family": "Larsson", "given": "Anna", "initials": "A"}, {"family": "Vernmark", "given": "Kristofer", "initials": "K"}, {"family": "Lilja", "given": "Josefine L", "initials": "JL"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Internet Interv", "issn": "2214-7829", "volume": "22", "issue": null, "pages": "100356", "issn-l": "2214-7829"}, "abstract": "To address the increasing mental health problems among young people, health care needs to broaden the spectrum of interventions and increase access to care. One particularly promising first-line intervention is cognitive behavioral therapy (CBT) delivered via the Internet (iCBT). The outbreak of the Coronavirus disease -2019 (COVID -19) has made the need for solid digital mental health care systems clear. This is the first published study exploring the transition among therapists of working with face-to-face treatment to using iCBT for youths suffering from anxiety treated in primary care.\n\nFourteen primary care therapists were included in the study. Semi-structured interviews (n = 26) were conducted on two occasions: before starting to use iCBT for youths, and at a subsequent follow-up after gaining treatment experience. Data was summarized into thematic categories.\n\nThe overarching themes that were identified were: Attitudes to iCBT before and after implementation; Experiences of treatment delivery; Characteristics of \"the right patient;\" and The role of the digital therapist.\n\nThe participants generally had positive attitudes to iCBT for youths and saw it as a valuable alternative to face-to-face treatments. However, they identified challenges related to patient selection, and to motivating patients and maintaining a therapeutic relationship through mainly written communication. The participants appreciated the increase in variety that iCBT brought to their schedules, and also experienced iCBT as a relief from common challenges of therapeutic work, such as emotional stress and high cognitive demands. The participating therapists' positive experiences support the introduction of iCBT for youths in routine primary care.", "doi": "10.1016/j.invent.2020.100356", "pmid": "33318951", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2214-7829(20)30122-6"}, {"db": "pmc", "key": "PMC7724368"}], "notes": [], "created": "2020-12-21T10:10:30.198Z", "modified": "2021-02-26T08:46:59.868Z"}, {"entity": "publication", "iuid": "e15a41ecb1524431b4580ca26555b4fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e15a41ecb1524431b4580ca26555b4fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e15a41ecb1524431b4580ca26555b4fa"}}, "title": "Thromboembolism, Hypercoagulopathy, and Antiphospholipid Antibodies in Critically Ill Coronavirus Disease 2019 Patients: A Before and After Study of Enhanced Anticoagulation", "authors": [{"family": "van der Linden", "given": "Jan", "initials": "J"}, {"family": "Almskog", "given": "Lou", "initials": "L"}, {"family": "Liliequist", "given": "Andreas", "initials": "A"}, {"family": "Grip", "given": "Jonathan", "initials": "J"}, {"family": "Fux", "given": "Thomas", "initials": "T"}, {"family": "Rysz", "given": "Susanne", "initials": "S"}, {"family": "\u00c5gren", "given": "Anna", "initials": "A"}, {"family": "Oldner", "given": "Anders", "initials": "A"}, {"family": "St\u00e5hlberg", "given": "Marcus", "initials": "M"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "Crit Care Explorations", "issn": "2639-8028", "issn-l": null, "volume": "2", "issue": "12", "pages": "e0308"}, "abstract": null, "doi": "10.1097/cce.0000000000000308", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-08T09:33:38.702Z", "modified": "2021-02-26T08:45:48.796Z"}, {"entity": "publication", "iuid": "224a7ae30efa43aa81366a5ea538dbcd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/224a7ae30efa43aa81366a5ea538dbcd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/224a7ae30efa43aa81366a5ea538dbcd"}}, "title": "The first eight months of Sweden's COVID-19 strategy and the key actions and actors that were involved.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF", "orcid": "0000-0003-1024-5602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1d5e45881a7469ca20a0eb360d891cc.json"}}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": "109", "issue": "12", "pages": "2459-2471", "issn-l": "0803-5253"}, "abstract": "COVID-19 has affected millions of people worldwide. This paper reviews the Swedish pandemic response.\n\nA narrative review was carried out and a timeline constructed.\n\nBy September 1, 2020, 0.8% of Swedish residents had tested positive for the virus and 0.06% of the population had died, which was higher than neighbouring Nordic countries, but lower than some European countries with general lockdowns. The main actors were the Public Health Agency, the National Board of Health and Welfare, the Civil Contingencies Agency and the Government. County councils and regions implemented policies, in conjunction with the Department of Education and county administrative boards. Sweden's response was less invasive than many other countries, with no general lockdown. It focused on mitigation: slowing, but not stopping, the pandemic. Physical distancing was recommended in public spaces, but mandatory in bars, restaurants and at events. Visits to nursing facilities were banned. Kindergartens and schools for children up to 16 stayed open, but closed for older children for three months. There were no enforced quarantines for infected households or geographical regions, and facemasks were not recommended outside health care.\n\nSweden chose a different pandemic strategy to its peer nations. This paper examines the first eight months.", "doi": "10.1111/apa.15582", "pmid": "32951258", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7537539"}], "notes": [], "created": "2020-11-26T12:26:45.047Z", "modified": "2023-01-13T13:29:39.327Z"}, {"entity": "publication", "iuid": "3694aab447f0437394fb108e7234d197", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3694aab447f0437394fb108e7234d197.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3694aab447f0437394fb108e7234d197"}}, "title": "The effect of interventions on COVID-19.", "authors": [{"family": "Soltesz", "given": "Kristian", "initials": "K", "orcid": "0000-0001-6378-7646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/936add4190154f9a8642f999147592e2.json"}}, {"family": "Gustafsson", "given": "Fredrik", "initials": "F"}, {"family": "Timpka", "given": "Toomas", "initials": "T"}, {"family": "Jald\u00e9n", "given": "Joakim", "initials": "J"}, {"family": "Jidling", "given": "Carl", "initials": "C"}, {"family": "Heimerson", "given": "Albin", "initials": "A"}, {"family": "Sch\u00f6n", "given": "Thomas B", "initials": "TB", "orcid": "0000-0001-5183-234X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/749950fca61f4c5b8801f4f22928594f.json"}}, {"family": "Spreco", "given": "Armin", "initials": "A", "orcid": "0000-0003-0985-8209", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29a7cab23d784f898e1706bb138caa0f.json"}}, {"family": "Ekberg", "given": "Joakim", "initials": "J"}, {"family": "Dahlstr\u00f6m", "given": "\u00d6rjan", "initials": "\u00d6"}, {"family": "Bagge Carlson", "given": "Fredrik", "initials": "F"}, {"family": "J\u00f6ud", "given": "Anna", "initials": "A"}, {"family": "Bernhardsson", "given": "Bo", "initials": "B"}], "type": "letter", "published": "2020-12-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "588", "issue": "7839", "pages": "E26-E28", "issn-l": "0028-0836"}, "abstract": null, "doi": "10.1038/s41586-020-3025-y", "pmid": "33361787", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41586-020-3025-y"}], "notes": [], "created": "2021-01-07T13:41:51.776Z", "modified": "2023-06-19T14:58:31.467Z"}, {"entity": "publication", "iuid": "7b92975b1b11441f935557260a1414e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b92975b1b11441f935557260a1414e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b92975b1b11441f935557260a1414e1"}}, "title": "Swedish policy analysis for Covid-19.", "authors": [{"family": "Kavaliunas", "given": "Andrius", "initials": "A"}, {"family": "Ocaya", "given": "Pauline", "initials": "P"}, {"family": "Mumper", "given": "Jim", "initials": "J"}, {"family": "Lindfeldt", "given": "Isis", "initials": "I"}, {"family": "Kyhlstedt", "given": "Mattias", "initials": "M"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Health Policy Technol", "issn": "2211-8837", "volume": "9", "issue": "4", "pages": "598-612", "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has challenged health care systems and put societies to the test in the world beyond expectations.\n\nOur aim is to describe and analyze the Swedish approach in combating the pandemic.\n\nWe present and discuss data collated from various sources - published scientific studies, pre-print material, agency reports, media communication, public surveys, etc. - with specific focus on the approach itself, Covid-19 trends, healthcare system response, policy and measures overview, and implications.\n\nThe main intervention to manage the curve has been the general recommendations to adhere to good hand hygiene, beware of physical distance to others, to refrain from large gatherings and restrain from non-essential travel. Persons with suspected Covid-19 infection were recommended to stay at home and avoid social contacts. Additionally, visits to the elderly care homes and meetings with more than 50 people were forbidden. As a result, the healthcare system in the country has so far, never been overwhelmed. However, the relatively high mortality among the elderly, together with the vulnerability of some migrants, points out the drawbacks.\n\nMany countries have both marvelled and criticized the Swedish strategy that is formed in a close partnership between the government and the society based on a mutual trust giving the responsibility to individuals. It already highlights how much can be achieved with voluntary measures (recommendations) - something that was noticed and proposed as a future model by the World Health Organization.", "doi": "10.1016/j.hlpt.2020.08.009", "pmid": "32904437", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S2211-8837(20)30081-2"}, {"db": "pmc", "key": "PMC7455549"}], "notes": [], "created": "2020-12-03T16:15:28.228Z", "modified": "2021-02-26T08:46:13.289Z"}, {"entity": "publication", "iuid": "e5040817d84e42569eeb6b0d5b2509f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e5040817d84e42569eeb6b0d5b2509f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e5040817d84e42569eeb6b0d5b2509f8"}}, "title": "Simple technology for COVID-19 medical solid waste treatment in low-resourced settings.", "authors": [{"family": "Bellizzi", "given": "Saverio", "initials": "S"}, {"family": "Kamal", "given": "Sherif A", "initials": "SA"}, {"family": "Newir", "given": "Ahmed E", "initials": "AE"}, {"family": "Pichierri", "given": "Giuseppe", "initials": "G"}, {"family": "Salaris", "given": "Paola", "initials": "P"}, {"family": "Pinto", "given": "Sergio", "initials": "S"}, {"family": "Farina", "given": "Gabriele", "initials": "G"}, {"family": "Fiamma", "given": "Maura", "initials": "M"}, {"family": "Maher", "given": "Osama Ali", "initials": "OA"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Glob Health", "issn": "2047-2986", "issn-l": "2047-2978", "volume": "10", "issue": "2", "pages": "020373"}, "abstract": null, "doi": "10.7189/jogh.10.020373", "pmid": "33282215", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jogh-10-020373"}, {"db": "pmc", "key": "PMC7688062"}], "notes": [], "created": "2020-12-10T09:17:40.665Z", "modified": "2020-12-10T09:18:26.221Z"}, {"entity": "publication", "iuid": "7a458bc696174cd6892145beb010c9c6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a458bc696174cd6892145beb010c9c6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a458bc696174cd6892145beb010c9c6"}}, "title": "Renin\u2013angiotensin system blockers and susceptibility to COVID-19: an international, open science, cohort analysis", "authors": [{"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Conover", "given": "Mitchell M", "initials": "MM"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Pratt", "given": "Nicole", "initials": "N"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "Fern\u00e1ndez-Bertol\u00edn", "given": "Sergio", "initials": "S"}, {"family": "Arag\u00f3n", "given": "Maria", "initials": "M"}, {"family": "DuVall", "given": "Scott L", "initials": "SL"}, {"family": "Lynch", "given": "Kristine", "initials": "K"}, {"family": "Falconer", "given": "Thomas", "initials": "T"}, {"family": "van Bochove", "given": "Kees", "initials": "K"}, {"family": "Sung", "given": "Cynthia", "initials": "C"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Lambert", "given": "Christophe G", "initials": "CG"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Williams", "given": "Andrew E", "initials": "AE"}, {"family": "Park", "given": "Rae Woong", "initials": "RW"}, {"family": "Weaver", "given": "James", "initials": "J"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Schuemie", "given": "Martijn J", "initials": "MJ"}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR"}, {"family": "Williams", "given": "Ross D", "initials": "RD"}, {"family": "Lane", "given": "Jennifer C E", "initials": "JCE"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Krumholz", "given": "Harlan M", "initials": "HM"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Ryan", "given": "Patrick B", "initials": "PB"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "The Lancet Digital Health", "issn": "2589-7500", "issn-l": null, "volume": "3", "issue": "2", "pages": "e98-e114"}, "abstract": null, "doi": "10.1016/s2589-7500(20)30289-2", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://data.ohdsi.org/IcariusSusceptibility/", "description": "Data aggregated by data source"}], "notes": [], "created": "2021-01-10T18:07:44.284Z", "modified": "2021-04-26T18:00:54.936Z"}, {"entity": "publication", "iuid": "e3fd6fbf88d1478283f699293b003c91", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3fd6fbf88d1478283f699293b003c91.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3fd6fbf88d1478283f699293b003c91"}}, "title": "Real-World Issues and Potential Solutions in Hematopoietic Cell Transplantation during the COVID-19 Pandemic: Perspectives from the Worldwide Network for Blood and Marrow Transplantation and Center for International Blood and Marrow Transplant Research Health Services and International Studies Committee.", "authors": [{"family": "Algwaiz", "given": "Ghada", "initials": "G"}, {"family": "Aljurf", "given": "Mahmoud", "initials": "M"}, {"family": "Koh", "given": "Mickey", "initials": "M"}, {"family": "Horowitz", "given": "Mary M", "initials": "MM"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Weisdorf", "given": "Daniel", "initials": "D"}, {"family": "Saber", "given": "Wael", "initials": "W"}, {"family": "Kodera", "given": "Yoshihisa", "initials": "Y"}, {"family": "Szer", "given": "Jeff", "initials": "J"}, {"family": "Jawdat", "given": "Dunia", "initials": "D"}, {"family": "Wood", "given": "William A", "initials": "WA"}, {"family": "Brazauskas", "given": "Ruta", "initials": "R"}, {"family": "Lehmann", "given": "Leslie", "initials": "L"}, {"family": "Pasquini", "given": "Marcelo C", "initials": "MC"}, {"family": "Seber", "given": "Adriana", "initials": "A"}, {"family": "Lu", "given": "Pei Hua", "initials": "PH"}, {"family": "Atsuta", "given": "Yoshiko", "initials": "Y"}, {"family": "Riches", "given": "Marcie", "initials": "M"}, {"family": "Perales", "given": "Miguel-Angel", "initials": "M"}, {"family": "Worel", "given": "Nina", "initials": "N"}, {"family": "Okamoto", "given": "Shinichiro", "initials": "S"}, {"family": "Srivastava", "given": "Alok", "initials": "A"}, {"family": "Chemaly", "given": "Roy F", "initials": "RF"}, {"family": "Cordonnier", "given": "Catherine", "initials": "C"}, {"family": "Dandoy", "given": "Christopher E", "initials": "CE"}, {"family": "Wingard", "given": "John R", "initials": "JR"}, {"family": "Kharfan-Dabaja", "given": "Mohamed A", "initials": "MA"}, {"family": "Hamadani", "given": "Mehdi", "initials": "M"}, {"family": "Majhail", "given": "Navneet S", "initials": "NS"}, {"family": "Waghmare", "given": "Alpana A", "initials": "AA"}, {"family": "Chao", "given": "Nelson", "initials": "N"}, {"family": "Kr\u00f6ger", "given": "Nicolaus", "initials": "N"}, {"family": "Shaw", "given": "Bronwen", "initials": "B"}, {"family": "Mohty", "given": "Mohamad", "initials": "M"}, {"family": "Niederwieser", "given": "Dietger", "initials": "D"}, {"family": "Greinix", "given": "Hildegard", "initials": "H"}, {"family": "Hashmi", "given": "Shahrukh K", "initials": "SK"}, {"family": "WBMT and the CIBMTR Health Services and International Studies Committee", "given": "", "initials": ""}], "type": "practice guideline", "published": "2020-12-00", "journal": {"title": "Biol Blood Marrow Transplant", "issn": "1523-6536", "issn-l": null, "volume": "26", "issue": "12", "pages": "2181-2189"}, "abstract": "The current COVID-19 pandemic, caused by SARS-CoV-2, has impacted many facets of hematopoietic cell transplantation (HCT) in both developed and developing countries. Realizing the challenges as a result of this pandemic affecting the daily practice of the HCT centers and the recognition of the variability in practice worldwide, the Worldwide Network for Blood and Marrow Transplantation (WBMT) and the Center for International Blood and Marrow Transplant Research's (CIBMTR) Health Services and International Studies Committee have jointly produced an expert opinion statement as a general guide to deal with certain aspects of HCT, including diagnostics for SARS-CoV-2 in HCT recipient, pre- and post-HCT management, donor issues, medical tourism, and facilities management. During these crucial times, which may last for months or years, the HCT community must reorganize to proceed with transplantation activity in those patients who urgently require it, albeit with extreme caution. This shared knowledge may be of value to the HCT community in the absence of high-quality evidence-based medicine. \u00a9 2020 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.", "doi": "10.1016/j.bbmt.2020.07.021", "pmid": "32717432", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1083-8791(20)30454-7"}, {"db": "pmc", "key": "PMC7380217"}], "notes": [], "created": "2020-12-07T16:12:27.503Z", "modified": "2020-12-11T12:52:49.859Z"}, {"entity": "publication", "iuid": "b5f72594dbb84c7d80156fb4fe5230aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5f72594dbb84c7d80156fb4fe5230aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5f72594dbb84c7d80156fb4fe5230aa"}}, "title": "Prospective role of thyroid disorders in monitoring COVID-19 pandemic.", "authors": [{"family": "Kumari", "given": "Kanchan", "initials": "K", "orcid": "0000-0001-7546-4174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/895c82c727734e4a8adf3f47ebf52a8d.json"}}, {"family": "Chainy", "given": "Gagan B N", "initials": "GBN"}, {"family": "Subudhi", "given": "Umakanta", "initials": "U", "orcid": "0000-0002-8271-1513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32d7e301f9304e68aac214ef5bb30455.json"}}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": "6", "issue": "12", "pages": "e05712", "issn-l": null}, "abstract": "COVID-19 pandemic has affected more than 200 countries and 1.3 million individuals have deceased within eleven months. Intense research on COVID-19 occurrence and prevalence enable us to understand that comorbidities play a crucial role in spread and severity of SARS-CoV-2 infection. Chronic kidney disease, diabetes, respiratory diseases and hypertension are among the various morbidities that are prevalent in symptomatic COVID-19 patients. However, the effect of altered thyroid-driven disorders cannot be ignored. Since thyroid hormone critically coordinate and regulate the major metabolism and biochemical pathways, this review is on the potential role of prevailing thyroid disorders in SARS-CoV-2 infection. Direct link of thyroid hormone with several disorders such as diabetes, vitamin D deficiency, obesity, kidney and liver disorders etc. suggests that the prevailing thyroid conditions may affect SARS-CoV-2 infection. Further, we discuss the oxidative stress-induced aging is associated with the degree of SARS-CoV-2 infection. Importantly, ACE2 protein which facilitates the host-cell entry of SARS-CoV-2 using the spike protein, are highly expressed in individuals with abnormal level of thyroid hormone. Altogether, we report that the malfunction of thyroid hormone synthesis may aggravate SARS-CoV-2 infection and thus monitoring the thyroid hormone may help in understanding the pathogenesis of COVID-19.", "doi": "10.1016/j.heliyon.2020.e05712", "pmid": "33344794", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(20)32555-X"}, {"db": "pmc", "key": "PMC7733548"}], "notes": [], "created": "2021-01-10T17:31:22.639Z", "modified": "2021-06-22T13:25:34.955Z"}, {"entity": "publication", "iuid": "d72c2b773cbc47f3bdbf32b03b3158df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d72c2b773cbc47f3bdbf32b03b3158df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d72c2b773cbc47f3bdbf32b03b3158df"}}, "title": "Perspectives and Consensus among International Orthopaedic Surgeons during Initial and Mid-lockdown Phases of Coronavirus Disease.", "authors": [{"family": "Jerome", "given": "J Terrence Jose", "initials": "JTJ"}, {"family": "Mercier", "given": "Francisco", "initials": "F"}, {"family": "Mudgal", "given": "Chaitanya S", "initials": "CS"}, {"family": "Arenas-Prat", "given": "Joan", "initials": "J"}, {"family": "Vinagre", "given": "Gustavo", "initials": "G"}, {"family": "Goorens", "given": "Chul Ki", "initials": "CK"}, {"family": "Rivera-Chavarr\u00eda", "given": "Ignacio J", "initials": "IJ"}, {"family": "Sechachalam", "given": "Sreedharan", "initials": "S"}, {"family": "Mofikoya", "given": "Bolaji", "initials": "B"}, {"family": "Thoma", "given": "Achilleas", "initials": "A"}, {"family": "Medina", "given": "Claudia", "initials": "C"}, {"family": "IlavarasuTamilmani 13", "given": "", "initials": ""}, {"family": "Henry", "given": "Mark", "initials": "M"}, {"family": "Afshar", "given": "Ahmadreza", "initials": "A"}, {"family": "Dailiana", "given": "Zoe H", "initials": "ZH"}, {"family": "Prasetyono", "given": "Theddeus O H", "initials": "TOH"}, {"family": "Artiaco", "given": "Stefano", "initials": "S"}, {"family": "Madhusudhan", "given": "Thayur R", "initials": "TR"}, {"family": "Ukaj", "given": "Skender", "initials": "S"}, {"family": "Reigstad", "given": "Ole", "initials": "O"}, {"family": "Hamada", "given": "Yoshitaka", "initials": "Y"}, {"family": "Bedi", "given": "Rajesh", "initials": "R"}, {"family": "Poggetti", "given": "Andrea", "initials": "A"}, {"family": "Al-Qattan", "given": "Mohammad Manna", "initials": "MM"}, {"family": "Siala", "given": "Mahdi", "initials": "M"}, {"family": "Viswanathan", "given": "Anand", "initials": "A"}, {"family": "Romero-Reveron", "given": "Rafael", "initials": "R"}, {"family": "Hong", "given": "Joon Pio", "initials": "JP"}, {"family": "Khalid", "given": "Kamarul Ariffin", "initials": "KA"}, {"family": "Bhaskaran", "given": "Shivashankar", "initials": "S"}, {"family": "Venkatadass", "given": "Krishnamoorthy", "initials": "K"}, {"family": "Leechavengvongs", "given": "Somsak", "initials": "S"}, {"family": "Nazim", "given": "Sifi", "initials": "S"}, {"family": "Georgescu", "given": "Alexandru Valentin", "initials": "AV"}, {"family": "Tremp", "given": "Mathias", "initials": "M"}, {"family": "Nakarmi", "given": "Kiran K", "initials": "KK"}, {"family": "Ellabban", "given": "Mohamed A", "initials": "MA"}, {"family": "Chan", "given": "Pingtak", "initials": "P"}, {"family": "Aristov", "given": "Andrey", "initials": "A"}, {"family": "Patel", "given": "Sandeep", "initials": "S"}, {"family": "Moreno-Serrano", "given": "Constanza L", "initials": "CL"}, {"family": "Rai", "given": "Shwetabh", "initials": "S"}, {"family": "Kanna", "given": "Rishi Mugesh", "initials": "RM"}, {"family": "Malshikare", "given": "Vijay A", "initials": "VA"}, {"family": "Tanabe", "given": "Katsuhisa", "initials": "K"}, {"family": "Thomas", "given": "Simon", "initials": "S"}, {"family": "Gokkus", "given": "Kemal", "initials": "K"}, {"family": "Baek", "given": "Seung-Hoon", "initials": "SH"}, {"family": "Brandt", "given": "Jerker", "initials": "J"}, {"family": "Rith", "given": "Yin", "initials": "Y"}, {"family": "Olazabal", "given": "Alfredo", "initials": "A"}, {"family": "Saaiq", "given": "Muhammad", "initials": "M"}, {"family": "Patil", "given": "Vijay", "initials": "V"}, {"family": "Jithendran", "given": "N", "initials": "N"}, {"family": "Parekh", "given": "Harshil", "initials": "H"}, {"family": "Minamikawa", "given": "Yoshitaka", "initials": "Y"}, {"family": "Atagawi", "given": "Abdulljawad Almabrouk", "initials": "AA"}, {"family": "Hadi", "given": "Jalal Ahmed", "initials": "JA"}, {"family": "Berezowsky", "given": "Claudia Arroyo", "initials": "CA"}, {"family": "Moya-Angeler", "given": "Joaquin", "initials": "J"}, {"family": "Altamirano-Cruz", "given": "Marco Antonio", "initials": "MA"}, {"family": "Galvis R", "given": "Luz Adriana", "initials": "LA"}, {"family": "Antezana", "given": "Alex", "initials": "A"}, {"family": "Paczesny", "given": "Lukasz", "initials": "L"}, {"family": "Fernandes", "given": "Carlos Henrique", "initials": "CH"}, {"family": "Asadullah", "given": "Md", "initials": "M"}, {"family": "Yuan-Shun", "given": "Lo", "initials": "L"}, {"family": "Makelov", "given": "Biser", "initials": "B"}, {"family": "Dodakundi", "given": "Chaitanya", "initials": "C"}, {"family": "Regmi", "given": "Rabindra", "initials": "R"}, {"family": "Pereira", "given": "Ganarlo Urquizo", "initials": "GU"}, {"family": "Zhang", "given": "Shuwei", "initials": "S"}, {"family": "Sayoojianadhan", "given": "Binoy", "initials": "B"}, {"family": "Callupe", "given": "Ivan", "initials": "I"}, {"family": "Rakha", "given": "Mohamed I", "initials": "MI"}, {"family": "Papes", "given": "Dino", "initials": "D"}, {"family": "Ganesan", "given": "Ramesh Prabu", "initials": "RP"}, {"family": "Mohan", "given": "Mukesh", "initials": "M"}, {"family": "Jeyaraman", "given": "Arun", "initials": "A"}, {"family": "Prabhakar", "given": "Ponnaian", "initials": "P"}, {"family": "Rajniashokan", "given": "Arungeethayan", "initials": "A"}, {"family": "Geethan", "given": "I", "initials": "I"}, {"family": "Chandrasekar", "given": "Sugavanam", "initials": "S"}, {"family": "L\u00f6w", "given": "Steffen", "initials": "S"}, {"family": "Thangavelu", "given": "Kannan", "initials": "K"}, {"family": "Giudici", "given": "Luca Dei", "initials": "LD"}, {"family": "Palanisamy", "given": "Yuvarajan", "initials": "Y"}, {"family": "Vaidyanathan", "given": "Singaravadivelu", "initials": "S"}, {"family": "Boretto", "given": "Jorge", "initials": "J"}, {"family": "Ramirez", "given": "Monica Alexandra", "initials": "MA"}, {"family": "Goundar", "given": "Thirumalaisamy Subbiah", "initials": "TS"}, {"family": "Kuppusamy", "given": "Thirumavalavan", "initials": "T"}, {"family": "Kanniyan", "given": "Kalaivanan", "initials": "K"}, {"family": "Srivastava", "given": "Atul", "initials": "A"}, {"family": "Chiu", "given": "Yung-Cheng", "initials": "YC"}, {"family": "Bhat", "given": "Anil K", "initials": "AK"}, {"family": "Gopinath", "given": "Nalli R", "initials": "NR"}, {"family": "Vasudevan", "given": "Vijayaraghavan P", "initials": "VP"}, {"family": "Abraham", "given": "Vineet", "initials": "V"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Hand Microsurg", "issn": "0974-3227", "volume": "12", "issue": "3", "pages": "135-162", "issn-l": null}, "abstract": "With a lot of uncertainty, unclear, and frequently changing management protocols, COVID-19 has significantly impacted the orthopaedic surgical practice during this pandemic crisis. Surgeons around the world needed closed introspection, contemplation, and prospective consensual recommendations for safe surgical practice and prevention of viral contamination. One hundred orthopaedic surgeons from 50 countries were sent a Google online form with a questionnaire explicating protocols for admission, surgeries, discharge, follow-up, relevant information affecting their surgical practices, difficulties faced, and many more important issues that happened during and after the lockdown. Ten surgeons critically construed and interpreted the data to form rationale guidelines and recommendations. Of the total, hand and microsurgery surgeons (52%), trauma surgeons (32%), joint replacement surgeons (20%), and arthroscopy surgeons (14%) actively participated in the survey. Surgeons from national public health care/government college hospitals (44%) and private/semiprivate practitioners (54%) were involved in the study. Countries had lockdown started as early as January 3, 2020 with the implementation of partial or complete lifting of lockdown in few countries while writing this article. Surgeons (58%) did not stop their surgical practice or clinics but preferred only emergency cases during the lockdown. Most of the surgeons (49%) had three-fourths reduction in their total patients turn-up and the remaining cases were managed by conservative (54%) methods. There was a 50 to 75% reduction in the number of surgeries. Surgeons did perform emergency procedures without COVID-19 tests but preferred reverse transcription polymerase chain reaction (RT-PCR; 77%) and computed tomography (CT) scan chest (12%) tests for all elective surgical cases. Open fracture and emergency procedures (60%) and distal radius (55%) fractures were the most commonly performed surgeries. Surgeons preferred full personal protection equipment kits (69%) with a respirator (N95/FFP3), but in the case of unavailability, they used surgical masks and normal gowns. Regional/local anesthesia (70%) remained their choice for surgery to prevent the aerosolized risk of contaminations. Essential surgical follow-up with limited persons and visits was encouraged by 70% of the surgeons, whereas teleconsultation and telerehabilitation by 30% of the surgeons. Despite the protective equipment, one-third of the surgeons were afraid of getting infected and 56% feared of infecting their near and dear ones. Orthopaedic surgeons in private practice did face 50 to 75% financial loss and have to furlough 25% staff and 50% paramedical persons. Orthopaedics meetings were cancelled, and virtual meetings have become the preferred mode of sharing the knowledge and experiences avoiding human contacts. Staying at home, reading, and writing manuscripts became more interesting and an interesting lifestyle change is seen among the surgeons. Unanimously and without any doubt all accepted the fact that COVID-19 pandemic has reached an unprecedented level where personal hygiene, hand washing, social distancing, and safe surgical practices are the viable antidotes, and they have all slowly integrated these practices into their lives. Strict adherence to local authority recommendations and guidelines, uniform and standardized norms for admission, inpatient, and discharge, mandatory RT-PCR tests before surgery and in selective cases with CT scan chest, optimizing and regularizing the surgeries, avoiding and delaying nonemergency surgeries and follow-up protocols, use of teleconsultations cautiously, and working in close association with the World Health Organization and national health care systems will provide a conducive and safe working environment for orthopaedic surgeons and their fraternity and also will prevent the resurgence of COVID-19.", "doi": "10.1055/s-0040-1713964", "pmid": "33408440", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "JHAM2000002"}, {"db": "pmc", "key": "PMC7773504"}], "notes": [], "created": "2021-01-08T07:19:07.003Z", "modified": "2021-01-08T07:19:07.024Z"}, {"entity": "publication", "iuid": "d50e4d3b23964fd892c53f371c4552f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d50e4d3b23964fd892c53f371c4552f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d50e4d3b23964fd892c53f371c4552f4"}}, "title": "Nordic welfare states\u2014still standing or changed by the COVID \u201019 crisis?", "authors": [{"family": "Greve", "given": "Bent", "initials": "B"}, {"family": "Blomquist", "given": "Paula", "initials": "P"}, {"family": "Hvinden", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "van Gerven", "given": "Minna", "initials": "M"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "Soc Policy Adm", "issn": "0144-5596", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1111/spol.12675", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-10T17:26:19.225Z", "modified": "2021-02-26T08:47:00.226Z"}, {"entity": "publication", "iuid": "8471851f2f744e6081ff4dddaaf3a426", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8471851f2f744e6081ff4dddaaf3a426.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8471851f2f744e6081ff4dddaaf3a426"}}, "title": "Mechanisms of a Sustained Anti\u2010inflammatory Drug Response in Alveolar Macrophages Unraveled with Mathematical Modeling", "authors": [{"family": "Nyman", "given": "Elin", "initials": "E"}, {"family": "Lindh", "given": "Maria", "initials": "M"}, {"family": "L\u00f6vfors", "given": "William", "initials": "W"}, {"family": "Simonsson", "given": "Christian", "initials": "C"}, {"family": "Persson", "given": "Alexander", "initials": "A"}, {"family": "Eklund", "given": "Daniel", "initials": "D"}, {"family": "B\u00e4ckstr\u00f6m", "given": "Erica", "initials": "E"}, {"family": "Frid\u00e9n", "given": "Markus", "initials": "M"}, {"family": "Cedersund", "given": "Gunnar", "initials": "G"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "CPT Pharmacometrics Syst. Pharmacol.", "issn": "2163-8306", "issn-l": null, "volume": "9", "issue": "12", "pages": "707-717"}, "abstract": "Both initiation and suppression of inflammation are hallmarks of the immune response. If not balanced, the inflammation may cause extensive tissue damage, which is associated with common diseases, e.g., asthma and atherosclerosis. Anti-inflammatory drugs come with side effects that may be aggravated by high and fluctuating drug concentrations. To remedy this, an anti-inflammatory drug should have an appropriate pharmacokinetic half-life or better still, a sustained anti-inflammatory drug response. However, we still lack a quantitative mechanistic understanding of such sustained effects. Here, we study the anti-inflammatory response to a common glucocorticoid drug, dexamethasone. We find a sustained response 22 hours after drug removal. With hypothesis testing using mathematical modeling, we unravel the underlying mechanism-a slow release of dexamethasone from the receptor-drug complex. The developed model is in agreement with time-resolved training and testing data and is used to simulate hypothetical treatment schemes. This work opens up for a more knowledge-driven drug development to find sustained anti-inflammatory responses and fewer side effects.", "doi": "10.1002/psp4.12568", "pmid": "33217190", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Funder: H2020": null, "Category: Biochemistry": null, "Category: Other": null}, "xrefs": [{"db": "URL", "key": "https://gitlab.liu.se/eliny61/macrophage-model", "description": "Experimental data and data analysis code"}], "notes": [], "created": "2021-01-17T08:51:36.015Z", "modified": "2021-06-14T14:35:41.477Z"}, {"entity": "publication", "iuid": "8a9dd1c8ce0a4fdfba93cd57897cfde8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a9dd1c8ce0a4fdfba93cd57897cfde8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a9dd1c8ce0a4fdfba93cd57897cfde8"}}, "title": "MR1-Restricted T Cells with MAIT-like Characteristics Are Functionally Conserved in the Pteropid Bat Pteropus alecto", "authors": [{"family": "Leeansyah", "given": "Edwin", "initials": "E"}, {"family": "Hey", "given": "Ying Ying", "initials": "YY"}, {"family": "Sia", "given": "Wan Rong", "initials": "WR"}, {"family": "Ng", "given": "Justin Han Jia", "initials": "JHJ"}, {"family": "Gulam", "given": "Muhammad Yaaseen", "initials": "MY"}, {"family": "Boulouis", "given": "Caroline", "initials": "C"}, {"family": "Zhu", "given": "Feng", "initials": "F"}, {"family": "Ahn", "given": "Matae", "initials": "M"}, {"family": "Mak", "given": "Jeffrey Y W", "initials": "JYW"}, {"family": "Fairlie", "given": "David P", "initials": "DP"}, {"family": "Kwa", "given": "Andrea Lay Hoon", "initials": "ALH"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Wang", "given": "Lin Fa", "initials": "LF"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "iScience", "issn": "2589-0042", "issn-l": "2589-0042", "volume": "23", "issue": "12", "pages": "101876"}, "abstract": "Bats are reservoirs for a large number of viruses which have potential to cause major human disease outbreaks, including the current coronavirus disease 2019 (COVID-19) pandemic. Major efforts are underway to understand bat immune response to viruses, whereas much less is known about their immune responses to bacteria. In this study, MR1-restricted T (MR1T) cells were detected through the use of MR1 tetramers in circulation and tissues of Pteropus alecto (Pa) bats. Pa MR1T cells exhibited weak responses to MR1-presented microbial metabolites at resting state. However, following priming with MR1-presented agonist they proliferated, upregulated critical transcription factors and cytolytic proteins, and gained transient expression of Th1/17-related cytokines and antibacterial cytotoxicity. Collectively, these findings show that the Pa bat immune system encompasses an abundant and functionally conserved population of MR1T cells with mucosal-associated invariant T-like characteristics, suggesting that MR1 and MR1T cells also play a significant role in bat immune defense.", "doi": "10.1016/j.isci.2020.101876", "pmid": "33344919", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-01-08T08:31:48.988Z", "modified": "2021-02-26T08:45:03.126Z"}, {"entity": "publication", "iuid": "a08d95668e6d4fa392a1660710854a87", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a08d95668e6d4fa392a1660710854a87.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a08d95668e6d4fa392a1660710854a87"}}, "title": "Lessons from COVID-19 on the role of the state and the market in providing early testing.", "authors": [{"family": "Morel", "given": "Chantal M", "initials": "CM"}, {"family": "Lindahl", "given": "Olof", "initials": "O"}, {"family": "\u00d6zenci", "given": "Volkan", "initials": "V"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Glob Health", "issn": "2047-2986", "volume": "10", "issue": "2", "pages": "020330", "issn-l": "2047-2978"}, "abstract": null, "doi": "10.7189/jogh.10.020330", "pmid": "33110530", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "jogh-10-020330"}, {"db": "pmc", "key": "PMC7561275"}], "notes": [], "created": "2020-11-19T19:29:19.519Z", "modified": "2020-11-27T10:22:50.060Z"}, {"entity": "publication", "iuid": "f568a85ab627477b80bcfb16151c32a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f568a85ab627477b80bcfb16151c32a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f568a85ab627477b80bcfb16151c32a1"}}, "title": "Laboratory management for SARS-CoV-2 detection: a user-friendly combination of the heat treatment approach and rt-Real-time PCR testing.", "authors": [{"family": "Mancini", "given": "Fabiola", "initials": "F"}, {"family": "Barbanti", "given": "Fabrizio", "initials": "F"}, {"family": "Scaturro", "given": "Maria", "initials": "M"}, {"family": "Errico", "given": "Giulia", "initials": "G"}, {"family": "Iacobino", "given": "Angelo", "initials": "A"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Marsili", "given": "Giulia", "initials": "G"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Rezza", "given": "Giovanni", "initials": "G"}, {"family": "Ciervo", "given": "Alessandra", "initials": "A"}, {"family": "on behalf ISS COVID-19 study group", "given": "", "initials": ""}], "type": "evaluation study", "published": "2020-12-00", "journal": {"title": "Emerg Microbes Infect", "issn": "2222-1751", "volume": "9", "issue": "1", "pages": "1393-1396", "issn-l": "2222-1751"}, "abstract": "The RNA purification is the gold standard for the detection of SARS-CoV-2 in swab samples, but it is dependent on the availability of chemical reagents. In this study, we evaluated the heat treatment method without RNA extraction as a reliable option to nucleic acid purification.", "doi": "10.1080/22221751.2020.1775500", "pmid": "32552549", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7473159"}], "notes": [], "created": "2020-12-09T07:49:54.116Z", "modified": "2021-02-26T08:46:13.606Z"}, {"entity": "publication", "iuid": "31658bdf82964e28bf165148ff841709", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/31658bdf82964e28bf165148ff841709.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/31658bdf82964e28bf165148ff841709"}}, "title": "Incidence and outcome of myocardial infarction treated with percutaneous coronary intervention during COVID-19 pandemic.", "authors": [{"family": "Mohammad", "given": "Moman A", "initials": "MA"}, {"family": "Koul", "given": "Sasha", "initials": "S"}, {"family": "Olivecrona", "given": "G\u00f6ran K", "initials": "GK"}, {"family": "G\u04e7tberg", "given": "Matthias", "initials": "M"}, {"family": "Tyd\u00e9n", "given": "Patrik", "initials": "P"}, {"family": "Rydberg", "given": "Erik", "initials": "E"}, {"family": "Scherst\u00e9n", "given": "Fredrik", "initials": "F"}, {"family": "Alfredsson", "given": "Joakim", "initials": "J"}, {"family": "Vasko", "given": "Peter", "initials": "P"}, {"family": "Omerovic", "given": "Elmir", "initials": "E"}, {"family": "Anger\u00e5s", "given": "Oskar", "initials": "O"}, {"family": "Fr\u00f6bert", "given": "Ole", "initials": "O"}, {"family": "Calais", "given": "Fredrik", "initials": "F"}, {"family": "V\u00f6lz", "given": "Sebastian", "initials": "S"}, {"family": "Ulvenstam", "given": "Anders", "initials": "A"}, {"family": "Venetsanos", "given": "Dimitrios", "initials": "D"}, {"family": "Yndigegn", "given": "Troels", "initials": "T"}, {"family": "Oldgren", "given": "Jonas", "initials": "J"}, {"family": "Sarno", "given": "Giovanna", "initials": "G"}, {"family": "Grimfj\u00e4rd", "given": "Per", "initials": "P"}, {"family": "Persson", "given": "Jonas", "initials": "J"}, {"family": "Witt", "given": "Nils", "initials": "N"}, {"family": "Ostenfeld", "given": "Ellen", "initials": "E"}, {"family": "Lindahl", "given": "Bertil", "initials": "B"}, {"family": "James", "given": "Stefan K", "initials": "SK"}, {"family": "Erlinge", "given": "David", "initials": "D"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Heart", "issn": "1468-201X", "issn-l": null, "volume": "106", "issue": "23", "pages": "1812-1818"}, "abstract": "Most reports on the declining incidence of myocardial infarction (MI) during the COVID-19 have either been anecdotal, survey results or geographically limited to areas with lockdowns. We examined the incidence of MI during the COVID-19 pandemic in Sweden, which has remained an open society with a different public health approach fighting COVID-19.\r\n\r\nWe assessed the incidence rate (IR) as well as the incidence rate ratios (IRRs) of all MI referred for coronary angiography in Sweden using the nationwide Swedish Coronary Angiography and Angioplasty Registry (SCAAR), during the COVID-19 pandemic in Sweden (1 March 2020-7 May 2020) in relation to the same days 2015-2019.\r\n\r\nA total of 2443 MIs were referred for coronary angiography during the COVID-19 pandemic resulting in an IR 36 MIs/day (204 MIs/100 000 per year) compared with 15 213 MIs during the reference period with an IR of 45 MIs/day (254 MIs/100 000 per year) resulting in IRR of 0.80, 95% CI (0.74 to 0.86), p<0.001. Results were consistent in all investigated patient subgroups, indicating no change in patient category seeking cardiac care. Kaplan-Meier event rates for 7-day case fatality were 439 (2.3%) compared with 37 (2.9%) (HR: 0.81, 95% CI (0.58 to 1.13), p=0.21). Time to percutaneous coronary intervention (PCI) was shorter during the pandemic and PCI was equally performed, indicating no change in quality of care during the pandemic.\r\n\r\nThe COVID-19 pandemic has significantly reduced the incidence of MI referred for invasive treatment strategy. No differences in overall short-term case fatality or quality of care indicators were observed.", "doi": "10.1136/heartjnl-2020-317685", "pmid": "33023905", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "heartjnl-2020-317685"}, {"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-12-01T18:13:48.157Z", "modified": "2021-02-26T08:46:59.885Z"}, {"entity": "publication", "iuid": "6aa068c605fd4b8bbbdbdb4c583803aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6aa068c605fd4b8bbbdbdb4c583803aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6aa068c605fd4b8bbbdbdb4c583803aa"}}, "title": "In Conversation with a Frontline Worker in a Care Home in Sweden during the COVID-19 Pandemic.", "authors": [{"family": "Kabir", "given": "Zarina N", "initials": "ZN"}, {"family": "Bostr\u00f6m", "given": "Anne-Marie", "initials": "A"}, {"family": "Konradsen", "given": "Hanne", "initials": "H"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Cross Cult Gerontol", "issn": "1573-0719", "issn-l": null, "volume": "35", "issue": "4", "pages": "493-500"}, "abstract": null, "doi": "10.1007/s10823-020-09415-7", "pmid": "33015728", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10823-020-09415-7"}, {"db": "pmc", "key": "PMC7533166"}], "notes": [], "created": "2020-12-03T08:52:20.615Z", "modified": "2022-11-23T09:03:41.112Z"}, {"entity": "publication", "iuid": "19007ffe053f4ce0a17b43ea23ac2ff0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19007ffe053f4ce0a17b43ea23ac2ff0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19007ffe053f4ce0a17b43ea23ac2ff0"}}, "title": "Impact of COVID-19 in paediatric early-phase cancer clinical trials in Europe: A report from the Innovative Therapies for Children with Cancer (ITCC) consortium.", "authors": [{"family": "Rubio-San-Sim\u00f3n", "given": "Alba", "initials": "A"}, {"family": "Andr\u00e9", "given": "Nicolas", "initials": "N"}, {"family": "Cefalo", "given": "Maria Giuseppina", "initials": "MG"}, {"family": "Aerts", "given": "Isabelle", "initials": "I"}, {"family": "Casta\u00f1eda", "given": "Alicia", "initials": "A"}, {"family": "Benezech", "given": "Sarah", "initials": "S"}, {"family": "Makin", "given": "Guy", "initials": "G"}, {"family": "van Eijkelenburg", "given": "Natasha", "initials": "N"}, {"family": "Nysom", "given": "Karsten", "initials": "K"}, {"family": "Marshall", "given": "Lynley", "initials": "L"}, {"family": "Gambart", "given": "Marion", "initials": "M"}, {"family": "Hladun", "given": "Raquel", "initials": "R"}, {"family": "Rossig", "given": "Claudia", "initials": "C"}, {"family": "Bergamaschi", "given": "Luca", "initials": "L"}, {"family": "Fagioli", "given": "Franca", "initials": "F"}, {"family": "Carpenter", "given": "Ben", "initials": "B"}, {"family": "Ducassou", "given": "Stephane", "initials": "S"}, {"family": "Owens", "given": "Cormac", "initials": "C"}, {"family": "\u00d8ra", "given": "Ingrid", "initials": "I"}, {"family": "Ribelles", "given": "Antonio Juan", "initials": "AJ"}, {"family": "De Wilde", "given": "Bram", "initials": "B"}, {"family": "Guerra-Garc\u00eda", "given": "Pilar", "initials": "P"}, {"family": "Strullu", "given": "Marion", "initials": "M"}, {"family": "Rizzari", "given": "Carmelo", "initials": "C"}, {"family": "Ek", "given": "Torben", "initials": "T"}, {"family": "Hettmer", "given": "Simone", "initials": "S"}, {"family": "Gerber", "given": "Nicolas U", "initials": "NU"}, {"family": "Rawlings", "given": "Christine", "initials": "C"}, {"family": "Diezi", "given": "Manuel", "initials": "M"}, {"family": "Palmu", "given": "Sauli", "initials": "S"}, {"family": "Ruggiero", "given": "Antonio", "initials": "A"}, {"family": "Verd\u00fa", "given": "Jaime", "initials": "J"}, {"family": "de Rojas", "given": "Teresa", "initials": "T"}, {"family": "Vassal", "given": "Gilles", "initials": "G"}, {"family": "Geoerger", "given": "Birgit", "initials": "B"}, {"family": "Moreno", "given": "Lucas", "initials": "L"}, {"family": "Bautista", "given": "Francisco", "initials": "F"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Eur J Cancer", "issn": "1879-0852", "issn-l": "0959-8049", "volume": "141", "issue": null, "pages": "82-91"}, "abstract": "Data regarding real-world impact on cancer clinical research during COVID-19 are scarce. We analysed the impact of the COVID-19 pandemic on the conduct of paediatric cancer phase I-II trials in Europe through the experience of the Innovative Therapies for Children with Cancer (ITCC).\r\n\r\nA survey was sent to all ITCC-accredited early-phase clinical trial hospitals including questions about impact on staff activities, recruitment, patient care, supply of investigational products and legal aspects, between 1st March and 30th April 2020.\r\n\r\nThirty-one of 53 hospitals from 12 countries participated. Challenges reported included staff constraints (30% drop), reduction in planned monitoring activity (67% drop of site initiation visits and 64% of monitoring visits) and patient recruitment (61% drop compared with that in 2019). The percentage of phase I, phase II trials and molecular platforms closing to recruitment in at least one site was 48.5%, 61.3% and 64.3%, respectively. In addition, 26% of sites had restrictions on performing trial assessments because of local contingency plans. Almost half of the units suffered impact upon pending contracts. Most hospitals (65%) are planning on improving organisational and structural changes.\r\n\r\nThe study reveals a profound disruption of paediatric cancer early-phase clinical research due to the COVID-19 pandemic across Europe. Reported difficulties affected both patient care and monitoring activity. Efforts should be made to reallocate resources to avoid lost opportunities for patients and to allow the continued advancement of oncology research. Identified adaptations to clinical trial procedures may be integrated to increase preparedness of clinical research to futures crises.", "doi": "10.1016/j.ejca.2020.09.024", "pmid": "33129040", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0959-8049(20)31029-7"}, {"db": "pmc", "key": "PMC7546235"}], "notes": [], "created": "2020-12-01T15:02:28.027Z", "modified": "2021-02-26T08:46:59.838Z"}, {"entity": "publication", "iuid": "a4de5d5c53974077a4b1cc5e40718bfd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a4de5d5c53974077a4b1cc5e40718bfd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a4de5d5c53974077a4b1cc5e40718bfd"}}, "title": "Guidance regarding COVID-19 for survivors of childhood, adolescent, and young adult cancer: A statement from the International Late Effects of Childhood Cancer Guideline Harmonization Group.", "authors": [{"family": "Verbruggen", "given": "Lisanne C", "initials": "LC"}, {"family": "Wang", "given": "Yuehan", "initials": "Y"}, {"family": "Armenian", "given": "Saro H", "initials": "SH"}, {"family": "Ehrhardt", "given": "Matthew J", "initials": "MJ"}, {"family": "van der Pal", "given": "Helena J H", "initials": "HJH"}, {"family": "van Dalen", "given": "Elvira C", "initials": "EC"}, {"family": "van As", "given": "Jorrit W", "initials": "JW"}, {"family": "Bardi", "given": "Edit", "initials": "E"}, {"family": "Baust", "given": "Katja", "initials": "K"}, {"family": "Berger", "given": "Claire", "initials": "C"}, {"family": "Castagnola", "given": "Elio", "initials": "E"}, {"family": "Devine", "given": "Katie A", "initials": "KA"}, {"family": "Gebauer", "given": "Judith", "initials": "J"}, {"family": "Marchak", "given": "Jordan Gilleland", "initials": "JG"}, {"family": "Glaser", "given": "Adam W", "initials": "AW"}, {"family": "Groll", "given": "Andreas H", "initials": "AH"}, {"family": "Haeusler", "given": "Gabrielle M", "initials": "GM"}, {"family": "den Hartogh", "given": "Jaap", "initials": "J"}, {"family": "Haupt", "given": "Riccardo", "initials": "R"}, {"family": "Hjorth", "given": "Lars", "initials": "L"}, {"family": "Kato", "given": "Miho", "initials": "M"}, {"family": "Kep\u00e1k", "given": "Tom\u00e1\u0161", "initials": "T"}, {"family": "Koopman", "given": "Maria M W Rianne", "initials": "MMWR"}, {"family": "Langer", "given": "Thorsten", "initials": "T"}, {"family": "Maeda", "given": "Miho", "initials": "M"}, {"family": "Michel", "given": "Gisela", "initials": "G"}, {"family": "Muraca", "given": "Monica", "initials": "M"}, {"family": "Nathan", "given": "Paul C", "initials": "PC"}, {"family": "van den Oever", "given": "Selina R", "initials": "SR"}, {"family": "Pavasovic", "given": "Vesna", "initials": "V"}, {"family": "Sato", "given": "Satomi", "initials": "S"}, {"family": "Schulte", "given": "Fiona", "initials": "F"}, {"family": "Sung", "given": "Lillian", "initials": "L"}, {"family": "Tissing", "given": "Wim", "initials": "W"}, {"family": "Uyttebroeck", "given": "Anne", "initials": "A"}, {"family": "Mulder", "given": "Ren\u00e9e L", "initials": "RL"}, {"family": "Kuehni", "given": "Claudia", "initials": "C"}, {"family": "Skinner", "given": "Roderick", "initials": "R"}, {"family": "Hudson", "given": "Melissa M", "initials": "MM"}, {"family": "Kremer", "given": "Leontien C M", "initials": "LCM"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Pediatr Blood Cancer", "issn": "1545-5017", "volume": "67", "issue": "12", "pages": "e28702", "issn-l": null}, "abstract": "Childhood, adolescent, and young adult (CAYA) cancer survivors may be at risk for a severe course of COVID-19. Little is known about the clinical course of COVID-19 in CAYA cancer survivors, or if additional preventive measures are warranted. We established a working group within the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) to summarize existing evidence and worldwide recommendations regarding evidence about factors/conditions associated with risk for a severe course of COVID-19 in CAYA cancer survivors, and to develop a consensus statement to provide guidance for healthcare practitioners and CAYA cancer survivors regarding COVID-19.", "doi": "10.1002/pbc.28702", "pmid": "32969160", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7537044"}], "notes": [], "created": "2020-12-03T15:09:18.905Z", "modified": "2020-12-03T15:09:45.512Z"}, {"entity": "publication", "iuid": "7bfa4880a578414c8706043aed8fc6e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7bfa4880a578414c8706043aed8fc6e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7bfa4880a578414c8706043aed8fc6e7"}}, "title": "Good old BCG - what a century-old vaccine can contribute to modern medicine.", "authors": [{"family": "Locht", "given": "C", "initials": "C"}, {"family": "Lerm", "given": "M", "initials": "M"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": "288", "issue": "6", "pages": "611-613", "issn-l": null}, "abstract": null, "doi": "10.1111/joim.13195", "pmid": "33315299", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-21T10:17:15.240Z", "modified": "2021-01-08T12:32:15.992Z"}, {"entity": "publication", "iuid": "379f21c57926472b8d4a756b34ca57bb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/379f21c57926472b8d4a756b34ca57bb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/379f21c57926472b8d4a756b34ca57bb"}}, "title": "Feasibility of telehealth in the management of autoimmune hepatitis before and during the COVID-19 pandemic.", "authors": [{"family": "Efe", "given": "Cumali", "initials": "C"}, {"family": "Sim\u015fek", "given": "Cem", "initials": "C"}, {"family": "Bat\u0131bay", "given": "Ersin", "initials": "E"}, {"family": "Cal\u0131\u015fkan", "given": "Ali R\u0131za", "initials": "AR"}, {"family": "Wahlin", "given": "Staffan", "initials": "S"}], "type": "comparative study", "published": "2020-12-00", "journal": {"title": "Expert Rev Gastroenterol Hepatol", "issn": "1747-4132", "issn-l": null, "volume": "14", "issue": "12", "pages": "1215-1219"}, "abstract": "We aimed to evaluate the feasibility of telehealth in the management of patients with autoimmune hepatitis (AIH). The COVID-19 outbreak during the study period provided an opportunity to evaluate any pandemic influence on how telehealth was perceived by patients and physicians.\r\n\r\nWe included patients with AIH who were followed in the Harran University hospital, Turkey. Patients were managed by either remote telehealth or standard care.\r\n\r\nA total of 46 (telehealth, n=19 and standard care, n= 27) patients (40 female) with a median age of 32 (range 17-74) years at diagnosis were included in the study. Until the start of the COVID-19 pandemic, the rates of biochemical remission and relapse after remission were similar in the telehealth and standard care groups (89.5% vs. 89.1% and 15.8% vs. 25.9%, p=ns, for both). The telehealth group maintained remission significantly better than the standard care group (100% vs. 77.3%, p=0.035) during the COVID-19 period. All relapses were due to non-adherence to therapy. Psychiatric problems, pregnancy-related issues and drug side-effects could all be managed remotely by telehealth.\r\n\r\nIn this study, we show for the first time that telehealth is a feasible alternative for managing AIH, both under normal circumstances and during the COVID-19 pandemic.\r\n\r\nAutoimmune hepatitis (AIH) requires long-life lifelong immunosuppression and follow-up for most patients. The use of telehealth may be an alternative way to evaluate these patients remotely. We show for the first time that telehealth is effective and useful in the management of AIH in regular time as well during COVID-19. We hope that our study can extend use of telehealth in the evaluation of patients with other causes of chronic liver disease.", "doi": "10.1080/17474124.2020.1822734", "pmid": "32909852", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2020-12-03T15:51:11.527Z", "modified": "2021-02-26T08:46:59.903Z"}, {"entity": "publication", "iuid": "9f6673a28f7a47d5a6129c5e51f0dcfd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f6673a28f7a47d5a6129c5e51f0dcfd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f6673a28f7a47d5a6129c5e51f0dcfd"}}, "title": "Factors related to preventive COVID-19 infection behaviors among people with mental illness.", "authors": [{"family": "Chang", "given": "Kun-Chia", "initials": "K"}, {"family": "Strong", "given": "Carol", "initials": "C"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Formos Med Assoc", "issn": "0929-6646", "issn-l": null, "volume": "119", "issue": "12", "pages": "1772-1780"}, "abstract": "Because of the spread of novel coronavirus disease 2019 (COVID-2019), preventive COVID-19 infection behaviors become important for individuals, especially those who are vulnerable. The present study proposes a model to explain the preventive COVID-19 infection behaviors among people with mental illness in Taiwan.\r\n\r\nA cross-sectional design was carried out and 414 patients with mental illness (230 males [55.6%]; mean age = 46.32 [SD = 10.86]) agreed to participate in the study. All the participants completed the Preventive COVID-19 Infection Behaviors Scale, Self-Stigma Scale-Short, Believing COVID-19 Information Scale, Fear of COVID-19 Scale, and Depression Anxiety Stress Scale-21. Regression models and structural equation modeling (SEM) were applied to examine the factors associated with preventive COVID-19 infection behaviors.\r\n\r\nBoth regression models and SEM showed that trust in COVID-19 information sources (standardized coefficient [\u03b2] = 0.211 in regression; \u03b2 = 0.194 in SEM) and fear of COVID-19 (\u03b2 = -0.128 in regression; \u03b2 = -0.223 in SEM) significantly explained preventive behaviors among individuals with mental illness. The SEM further showed that fear of COVID-19 was significantly explained by trust in COVID-19 information sources (\u03b2 = 0.220) and self-stigma (\u03b2 = 0.454).\r\n\r\nBased on the results, healthcare providers should help individuals with mental illness reduce self-stigma and fear of COVID-19 which would consequently improve their preventive COVID-19 infection behaviors. Moreover, improving trust in COVID-19 information sources for individuals with mental illness may be another method to improve their preventive behaviors.", "doi": "10.1016/j.jfma.2020.07.032", "pmid": "32773260", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0929-6646(20)30344-2"}, {"db": "pmc", "key": "PMC7388748"}], "notes": [], "created": "2020-12-07T13:33:24.123Z", "modified": "2021-02-26T08:47:00.110Z"}, {"entity": "publication", "iuid": "ca7515e94a4946148ea2fe65f49320d8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ca7515e94a4946148ea2fe65f49320d8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ca7515e94a4946148ea2fe65f49320d8"}}, "title": "Epidemiological characteristics of COVID-19 cases and estimates of the reproductive numbers 1 month into the epidemic, Italy, 28 January to 31 March 2020.", "authors": [{"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Ajelli", "given": "Marco", "initials": "M"}, {"family": "Andrianou", "given": "Xanthi D", "initials": "XD"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Bellino", "given": "Stefania", "initials": "S"}, {"family": "Boros", "given": "Stefano", "initials": "S"}, {"family": "Urdiales", "given": "Alberto Mateo", "initials": "AM"}, {"family": "Marziano", "given": "Valentina", "initials": "V"}, {"family": "Rota", "given": "Maria Cristina", "initials": "MC"}, {"family": "Filia", "given": "Antonietta", "initials": "A"}, {"family": "D'Ancona", "given": "Fortunato", "initials": "F"}, {"family": "Siddu", "given": "Andrea", "initials": "A"}, {"family": "Punzo", "given": "Ornella", "initials": "O"}, {"family": "Trentini", "given": "Filippo", "initials": "F"}, {"family": "Guzzetta", "given": "Giorgio", "initials": "G"}, {"family": "Poletti", "given": "Piero", "initials": "P"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Castrucci", "given": "Maria Rita", "initials": "MR"}, {"family": "Ciervo", "given": "Alessandra", "initials": "A"}, {"family": "Di Benedetto", "given": "Corrado", "initials": "C"}, {"family": "Tallon", "given": "Marco", "initials": "M"}, {"family": "Piccioli", "given": "Andrea", "initials": "A"}, {"family": "Brusaferro", "given": "Silvio", "initials": "S"}, {"family": "Rezza", "given": "Giovanni", "initials": "G"}, {"family": "Merler", "given": "Stefano", "initials": "S"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "COVID-19 working group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "49", "issn-l": null}, "abstract": "BackgroundOn 20 February 2020, a locally acquired coronavirus disease (COVID-19) case was detected in Lombardy, Italy. This was the first signal of ongoing transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the country. The number of cases in Italy increased rapidly and the country became the first in Europe to experience a SARS-CoV-2 outbreak.AimOur aim was to describe the epidemiology and transmission dynamics of the first COVID-19 cases in Italy amid ongoing control measures.MethodsWe analysed all RT-PCR-confirmed COVID-19 cases reported to the national integrated surveillance system until 31 March 2020. We provide a descriptive epidemiological summary and estimate the basic and net reproductive numbers by region.ResultsOf the 98,716 cases of COVID-19 analysed, 9,512 were healthcare workers. Of the 10,943 reported COVID-19-associated deaths (crude case fatality ratio: 11.1%) 49.5% occurred in cases older than 80 years. Male sex and age were independent risk factors for COVID-19 death. Estimates of R 0 varied between 2.50 (95% confidence interval (CI): 2.18-2.83) in Tuscany and 3.00 (95% CI: 2.68-3.33) in Lazio. The net reproduction number Rt in northern regions started decreasing immediately after the first detection.ConclusionThe COVID-19 outbreak in Italy showed a clustering onset similar to the one in Wuhan, China. R0 at 2.96 in Lombardy combined with delayed detection explains the high case load and rapid geographical spread. Overall, Rt in Italian regions showed early signs of decrease, with large diversity in incidence, supporting the importance of combined non-pharmacological control measures.", "doi": "10.2807/1560-7917.ES.2020.25.49.2000790", "pmid": "33303064", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2020-12-13T07:20:07.307Z", "modified": "2021-02-26T08:47:00.193Z"}, {"entity": "publication", "iuid": "1e5d9f78dde24cba9062f2039ddf6fd7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1e5d9f78dde24cba9062f2039ddf6fd7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1e5d9f78dde24cba9062f2039ddf6fd7"}}, "title": "Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells.", "authors": [{"family": "Appelberg", "given": "Sofia", "initials": "S"}, {"family": "Gupta", "given": "Soham", "initials": "S"}, {"family": "Svensson Akusj\u00e4rvi", "given": "Sara", "initials": "S"}, {"family": "Ambikan", "given": "Anoop T", "initials": "AT"}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "Saccon", "given": "Elisa", "initials": "E"}, {"family": "V\u00e9gv\u00e1ri", "given": "\u00c1kos", "initials": "\u00c1"}, {"family": "Benfeitas", "given": "Rui", "initials": "R"}, {"family": "Sperk", "given": "Maike", "initials": "M"}, {"family": "St\u00e5hlberg", "given": "Marie", "initials": "M"}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Singh", "given": "Kamal", "initials": "K"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Emerg Microbes Infect", "issn": "2222-1751", "issn-l": "2222-1751", "volume": "9", "issue": "1", "pages": "1748-1760"}, "abstract": "How severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections engage cellular host pathways and innate immunity in infected cells remains largely elusive. We performed an integrative proteo-transcriptomics analysis in SARS-CoV-2 infected Huh7 cells to map the cellular response to the invading virus over time. We identified four pathways, ErbB, HIF-1, mTOR and TNF signaling, among others that were markedly modulated during the course of the SARS-CoV-2 infection in vitro. Western blot validation of the downstream effector molecules of these pathways revealed a dose-dependent activation of Akt, mTOR, S6K1 and 4E-BP1 at 24 hours post infection (hpi). However, we found a significant inhibition of HIF-1\u03b1 through 24hpi and 48hpi of the infection, suggesting a crosstalk between the SARS-CoV-2 and the Akt/mTOR/HIF-1 signaling pathways. Inhibition of the mTOR signaling pathway using Akt inhibitor MK-2206 showed a significant reduction in virus production. Further investigations are required to better understand the molecular sequelae in order to guide potential therapy in the management of severe coronavirus disease 2019 (COVID-19) patients.", "doi": "10.1080/22221751.2020.1799723", "pmid": "32691695", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "SRA", "key": "PRJNA627100", "description": "Raw RNAseq data"}, {"db": "URL", "key": "10.5281/zenodo.3754718", "description": "Proteomic data"}, {"db": "URL", "key": "https://github.com/neogilab/COVID19", "description": "Data analysis code"}], "notes": [], "created": "2020-11-18T16:47:18.250Z", "modified": "2021-02-26T08:45:47.926Z"}, {"entity": "publication", "iuid": "05363d49d5664a15846bc90192ce1f7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/05363d49d5664a15846bc90192ce1f7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/05363d49d5664a15846bc90192ce1f7e"}}, "title": "Development and external validation of a COVID-19 mortality risk prediction algorithm: a multicentre retrospective cohort study", "authors": [{"family": "Mei", "given": "Jin", "initials": "J"}, {"family": "Hu", "given": "Weihua", "initials": "W"}, {"family": "Chen", "given": "Qijian", "initials": "Q"}, {"family": "Li", "given": "Chang", "initials": "C"}, {"family": "Chen", "given": "Zaishu", "initials": "Z"}, {"family": "Fan", "given": "Yanjie", "initials": "Y"}, {"family": "Tian", "given": "Shuwei", "initials": "S"}, {"family": "Zhang", "given": "Zhuheng", "initials": "Z"}, {"family": "Li", "given": "Bin", "initials": "B"}, {"family": "Ye", "given": "Qifa", "initials": "Q"}, {"family": "Yue", "given": "Jiang", "initials": "J"}, {"family": "Wang", "given": "Qiao Li", "initials": "QL"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "10", "issue": "12", "pages": "e044028", "issn-l": "2044-6055"}, "abstract": null, "doi": "10.1136/bmjopen-2020-044028", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-10T17:29:16.471Z", "modified": "2021-02-26T08:46:59.808Z"}, {"entity": "publication", "iuid": "75453bffbf5d4bd8809071c66b55abe7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/75453bffbf5d4bd8809071c66b55abe7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/75453bffbf5d4bd8809071c66b55abe7"}}, "title": "Depression, anxiety, and stress mediate the associations between internet gaming disorder, insomnia, and quality of life during the COVID-19 outbreak.", "authors": [{"family": "Fazeli", "given": "Sara", "initials": "S"}, {"family": "Mohammadi Zeidi", "given": "Isa", "initials": "I"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Namdar", "given": "Peyman", "initials": "P"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Addict Behav Rep", "issn": "2352-8532", "issn-l": null, "volume": "12", "issue": null, "pages": "100307"}, "abstract": "For many individuals, the COVID-19 outbreak has increased their psychological distress, changed their behaviors, and impacted their health. With more time spent indoors, many individuals have engaged in increased videogame playing. However, the associations between such behaviors during the COVID-19 outbreak period is unclear.\r\n\r\nThe present study examined the mediating role of psychological distress (depression, anxiety, and stress) in the association between internet gaming disorder (IGD) and two health outcomes (insomnia quality of life) among adolescents during this COVID-19 pandemic.\r\n\r\nA cross-sectional study comprising adolescents ( N = 1512) aged 13-18 years (mean age = 15.51 years) was utilized to assess measures on insomnia, depression, anxiety, and stress, IGD, and quality of life during the COVID-19 pandemic.\r\n\r\nThere were small to large significant relationships between the variables. Psychological distress (i.e., depression, anxiety, and stress) served as a strong mediator in the association between IGD and insomnia and quality of life. IGD directly influenced insomnia and quality of life among the participants.\r\n\r\nIGD is associated with different psychosocial outcomes comprising multiple pathways. Parents need to pay special attention to how much time and how frequently their children play videogames. Parents may need to assist their children in coping with psychological distress during the ongoing COVID-19 pandemic period.", "doi": "10.1016/j.abrep.2020.100307", "pmid": "33110934", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S2352-8532(20)30122-X"}, {"db": "pmc", "key": "PMC7581367"}], "notes": [], "created": "2020-12-01T15:13:19.560Z", "modified": "2022-11-23T09:04:00.250Z"}, {"entity": "publication", "iuid": "aa40739fe513445582a64d793c977c8c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aa40739fe513445582a64d793c977c8c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aa40739fe513445582a64d793c977c8c"}}, "title": "Creating and applying SIR modified compartmental model for calculation of COVID-19 lockdown efficiency.", "authors": [{"family": "Sharov", "given": "Konstantin S", "initials": "KS"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Chaos Solitons Fractals", "issn": "0960-0779", "volume": "141", "issue": null, "pages": "110295", "issn-l": null}, "abstract": "We propose a Susceptible-Infected-Recovered (SIR) modified model for Coronavirus disease - 2019 (COVID-19) spread to estimate the efficacy of lockdown measures introduced during the pandemic. As input data, we used COVID-19 epidemiological information collected in fifteen European countries either in private surveys or using official statistics. Thirteen countries implemented lockdown measures, two countries (Sweden, Iceland) not. As output parameters, we studied herd immunity level and time of formation. Comparison of these parameters was used as an indicator of effectiveness / ineffectiveness of lockdown measures. In the absence of a medical vaccine, herd immunity may be regarded as a factor of population adaptation to severe acute respiratory syndrome-related coronavirus-2, the viral pathogen causing COVID-19 disease (SARS-CoV-2), and hence COVID-19 spreading stop. We demonstrated that there is no significant difference between lockdown and no-lockdown modes of COVID-19 containment, in terms of both herd immunity level and the time of achieving its maximum. The rationale for personal and business lockdowns may be found in the avoidance of healthcare system overburdening. However, lockdowns do not prevent any virus with droplet transmission (including SARS-CoV-2) from spreading. Therefore, in case of a future viral pathogen emergence, lockdown measures efficiency should not be overestimated, as it was done almost universally in the world during COVID-19 pandemic.", "doi": "10.1016/j.chaos.2020.110295", "pmid": "32994671", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0960-0779(20)30691-3"}, {"db": "pmc", "key": "PMC7513696"}], "notes": [], "created": "2020-12-03T09:02:25.737Z", "modified": "2021-02-26T08:46:13.423Z"}, {"entity": "publication", "iuid": "f7940db8b9524e11ac7837dfecd62eaa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7940db8b9524e11ac7837dfecd62eaa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7940db8b9524e11ac7837dfecd62eaa"}}, "title": "Corrigendum to \"Depression, anxiety, and stress mediate the associations between internet gaming disorder, insomnia, and quality of life during the COVID-19 outbreak\" [Addict. Behav. Rep. 12 (2020) 100307].", "authors": [{"family": "Fazeli", "given": "Sara", "initials": "S"}, {"family": "Zeidi", "given": "Isa Mohammadi", "initials": "IM"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Namdar", "given": "Peyman", "initials": "P"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Pakpour", "given": "Amir", "initials": "A"}], "type": "published erratum", "published": "2020-12-00", "journal": {"title": "Addict Behav Rep", "issn": "2352-8532", "volume": "12", "issue": null, "pages": "100322", "issn-l": null}, "abstract": "[This corrects the article DOI: 10.1016/j.abrep.2020.100307.].", "doi": "10.1016/j.abrep.2020.100322", "pmid": "33364329", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2352-8532(20)30137-1"}, {"db": "pmc", "key": "PMC7752708"}], "notes": [], "created": "2021-01-07T13:39:25.551Z", "modified": "2021-01-10T17:24:39.710Z"}, {"entity": "publication", "iuid": "dd5e75653bbc4f49a1f4579c267db46f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dd5e75653bbc4f49a1f4579c267db46f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dd5e75653bbc4f49a1f4579c267db46f"}}, "title": "COVID-19 and Possible Pharmacological Preventive Options.", "authors": [{"family": "Duner", "given": "Pontus", "initials": "P"}, {"family": "Salehi", "given": "Albert", "initials": "A"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Clin Med Res", "issn": "1918-3003", "issn-l": null, "volume": "12", "issue": "12", "pages": "758-772"}, "abstract": "The dreadful fear of the coronavirus disease 2019 (COVID-19), which is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with the deadly consequences, requires rapid development of pharmacological cures. The objective of this review is to speculate about possible pharmacological options, already available today to prevent or treat the COVID-19 in the early stage of its outbreak. A literature search across PubMed and internet was conducted. A number of studies dealing with COVID-19 were identified. The data elucidated that increased pro-inflammatory and decreased anti-inflammatory cytokines in combination with hypoxia, thromboembolism and pneumonia are involved in the pathogenesis of SARS-CoV-2 infection. Although many drugs has been tested in monotherapy regimen with varying outcome or without desirable effect, there is still hope for better results by simultaneously targeting the virus itself and its symptoms. Theoretically, a mixture of at least two available antiviral drugs in combination with other anti-pathogenic and immune system-enhancing drugs or combination of antiviral drugs with convalescent plasma seems likely to have much better effect than the monotherapy regimen of either of these drugs.", "doi": "10.14740/jocmr4383", "pmid": "33447309", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7781281"}], "notes": [], "created": "2021-01-15T13:08:11.011Z", "modified": "2021-07-14T07:51:34.954Z"}, {"entity": "publication", "iuid": "f4072870300d4088af6f5c7d2c45b82e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f4072870300d4088af6f5c7d2c45b82e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f4072870300d4088af6f5c7d2c45b82e"}}, "title": "COVID-19 and NSAIDS: A Narrative Review of Knowns and Unknowns.", "authors": [{"family": "Pergolizzi", "given": "Joseph V", "initials": "JV"}, {"family": "Varrassi", "given": "Giustino", "initials": "G"}, {"family": "Magnusson", "given": "Peter", "initials": "P"}, {"family": "LeQuang", "given": "Jo Ann", "initials": "JA"}, {"family": "Paladini", "given": "Antonella", "initials": "A"}, {"family": "Taylor", "given": "Robert", "initials": "R"}, {"family": "Wollmuth", "given": "Charles", "initials": "C"}, {"family": "Breve", "given": "Frank", "initials": "F"}, {"family": "Christo", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Pain Ther", "issn": "2193-8237", "volume": "9", "issue": "2", "pages": "353-358", "issn-l": null}, "abstract": "Concern about the appropriate role of nonsteroidal anti-inflammatory drugs (NSAIDs) in COVID-19 speculate that NSAIDs, in particular ibuprofen, may upregulate the entry point for the virus, the angiotensin-converting enzyme (ACE) 2 receptors and increase susceptibility to the virus or worsen symptoms in existing disease. Adverse outcomes with COVID-19 have been linked to cytokine storm but the most effective way to address exaggerated inflammatory response is complex and unclear. The Expert Working Group on the Commission of Human Medicines in the UK and other organizations have stated that there is insufficient evidence to establish a link between ibuprofen and susceptibility to or exacerbation of COVID-19. NSAID use must also be categorized by whether the drugs are relatively low-dose over-the-counter oral products taken occasionally versus higher-dose or parenteral NSAIDs. Even if evidence emerged arguing for or against NSAIDs in this setting, it is unclear if this evidence would apply to all NSAIDs at all doses in all dosing regimens. Paracetamol (acetaminophen) has been proposed as an alternative to NSAIDs but there are issues with liver toxicity at high doses. There are clearly COVID-19 cases where NSAIDs should not be used, but there is no strong evidence that NSAIDs must be avoided in all patients with COVID-19; clinicians must weigh these choices on an individual basis.", "doi": "10.1007/s40122-020-00173-5", "pmid": "32447629", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40122-020-00173-5"}, {"db": "pmc", "key": "PMC7245573"}], "notes": [], "created": "2020-11-25T09:13:50.558Z", "modified": "2020-11-30T09:03:27.305Z"}, {"entity": "publication", "iuid": "887e076a51704634b4f27fc6fbf095bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/887e076a51704634b4f27fc6fbf095bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/887e076a51704634b4f27fc6fbf095bd"}}, "title": "Blood type A associates with critical COVID-19 and death in a Swedish cohort", "authors": [{"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Persson", "given": "Barbro", "initials": "B"}, {"family": "Eriksson", "given": "Oskar", "initials": "O"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Nilsson", "given": "Bo", "initials": "B"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "Crit Care", "issn": "1364-8535", "issn-l": null, "volume": "24", "issue": "1", "pages": "496"}, "abstract": "No abstract available", "doi": "10.1186/s13054-020-03223-8", "pmid": "32787887", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Funder: VR: Special COVID-19 funding": null, "Category: Serology": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-10-30T12:03:20.383Z", "modified": "2022-02-14T06:44:05.982Z"}, {"entity": "publication", "iuid": "688925461d514ca8ba840a2028fdbcbc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/688925461d514ca8ba840a2028fdbcbc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/688925461d514ca8ba840a2028fdbcbc"}}, "title": "Amyloid nomenclature 2020: update and recommendations by the International Society of Amyloidosis (ISA) nomenclature committee.", "authors": [{"family": "Benson", "given": "Merrill D", "initials": "MD"}, {"family": "Buxbaum", "given": "Joel N", "initials": "JN"}, {"family": "Eisenberg", "given": "David S", "initials": "DS"}, {"family": "Merlini", "given": "Giampaolo", "initials": "G"}, {"family": "Saraiva", "given": "Maria J M", "initials": "MJM"}, {"family": "Sekijima", "given": "Yoshiki", "initials": "Y"}, {"family": "Sipe", "given": "Jean D", "initials": "JD"}, {"family": "Westermark", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Amyloid", "issn": "1744-2818", "volume": "27", "issue": "4", "pages": "217-222", "issn-l": null}, "abstract": "The ISA Nomenclature Committee met electronically before and directly after the XVII ISA International Symposium on Amyloidosis, which, unfortunately, had to be virtual in September 2020 due to the ongoing COVID-19 pandemic instead of a planned meeting in Tarragona in March. In addition to confirmation of basic nomenclature, several additional concepts were discussed, which are used in scientific amyloid literature. Among such concepts are cytotoxic oligomers, protofibrils, primary and secondary nucleation, seeding and cross-seeding, amyloid signature proteins, and amyloid plaques. Recommendations for their use are given. Definitions of amyloid and amyloidosis are confirmed. Possible novel human amyloid fibril proteins, appearing as 'classical' in vivo amyloid, were discussed. It was decided to include fibulin-like extracellular matrix protein 1 (amyloid protein: AEFEMP1), which appears as localised amyloid in portal veins. There are several possible amyloid proteins under investigation, and these are included in a new Table.", "doi": "10.1080/13506129.2020.1835263", "pmid": "33100054", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-01T15:32:13.763Z", "modified": "2020-12-01T15:32:13.783Z"}, {"entity": "publication", "iuid": "e7deb7bc299b44baa345a5adadb72799", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e7deb7bc299b44baa345a5adadb72799.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e7deb7bc299b44baa345a5adadb72799"}}, "title": "A timely update of global COVID-19 vaccine development.", "authors": [{"family": "Klavinskis", "given": "Linda S", "initials": "LS"}, {"family": "Liu", "given": "Margaret A", "initials": "MA"}, {"family": "Lu", "given": "Shan", "initials": "S"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Emerg Microbes Infect", "issn": "2222-1751", "issn-l": "2222-1751", "volume": "9", "issue": "1", "pages": "2379-2380"}, "abstract": "Commentary\r\nThis commentary provides an overview and links to presentations of a recent virtual congress series organized by the International Society for Vaccines (ISV) focused on COVID-19 vaccines. The series provided the academic community and vaccine developers as well as the wider general public with balanced information of the global response and resources for COVID-19 vaccines under development featuring: 1) NGOs and the regulatory perspective, 2) the status of vaccine development efforts, and 3) panel discussions to present and discuss challenges. ISV is a non-profit scientific organization whose members work on all areas relevant to vaccines. ISV plans to host additional virtual symposia including regional meetings and incorporating other topics along with COVID-19 vaccines.", "doi": "10.1080/22221751.2020.1838246", "pmid": "33059515", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7605319"}], "notes": [], "created": "2020-12-01T17:09:58.043Z", "modified": "2020-12-01T17:10:16.674Z"}, {"entity": "publication", "iuid": "eacb488d3071417b9b63d43c96028d43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eacb488d3071417b9b63d43c96028d43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eacb488d3071417b9b63d43c96028d43"}}, "title": "A systematic review and meta-analysis of the use of renin-angiotensin system drugs and COVID-19 clinical outcomes: What is the evidence so far?", "authors": [{"family": "Kurdi", "given": "Amanj", "initials": "A"}, {"family": "Abutheraa", "given": "Nouf", "initials": "N"}, {"family": "Akil", "given": "Lina", "initials": "L"}, {"family": "Godman", "given": "Brian", "initials": "B"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Pharmacol Res Perspect", "issn": "2052-1707", "volume": "8", "issue": "6", "pages": "e00666", "issn-l": "2052-1707"}, "abstract": "Conflicting evidence exists about the effect of angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs) on COVID-19 clinical outcomes. We aimed to provide a comprehensive/updated evaluation of the effect of ACEIs/ARBs on COVID-19-related clinical outcomes, including exploration of interclass differences between ACEIs and ARBs, using a systematic review/meta-analysis approach conducted in Medline (OVID), Embase, Scopus, Cochrane library, and medRxiv from inception to 22 May 2020. English studies that evaluated the effect of ACEIs/ARBs among patients with COVID-19 were included. Studies' quality was appraised using the Newcastle-Ottawa Scale. Data were analyzed using the random-effects modeling stratified by exposure (ACEIs/ARBs, ACEIs, and ARBs). Heterogeneiity was assessed using I 2 statistic. Several subgroup analyses were conducted to explore the impact of potential confounders. Overall, 27 studies were eligible. The pooled analyses showed nonsignificant associations between ACEIs/ARBs and death (OR:0.97, 95%CI:0.75,1.27), ICU admission (OR:1.09;95%CI:0.65,1.81), death/ICU admission (OR:0.67; 95%CI:0.52,0.86), risk of COVID-19 infection (OR:1.01; 95%CI:0.93,1.10), severe infection (OR:0.78; 95%CI:0.53,1.15), and hospitalization (OR:1.15; 95%CI:0.81,1.65). However, the subgroup analyses indicated significant association between ACEIs/ARBs and hospitalization among USA studies (OR:1.59; 95%CI:1.03,2.44), peer-reviewed (OR:1.93, 95%CI:1.38,2.71), good quality and studies which reported adjusted measure of effect (OR:1.30, 95%CI:1.10,1.50). Significant differences were found between ACEIs and ARBs with the latter being significantly associated with lower risk of acquiring COVID-19 infection (OR:0.24; 95%CI: 0.17,0.34). In conclusion, high-quality evidence exists for the effect of ACEIs/ARBs on some COVID-19 clinical outcomes. For the first time, we provided evidence, albeit of low quality, on interclass differences between ACEIs and ARBs for some of the reported clinical outcomes.", "doi": "10.1002/prp2.666", "pmid": "33084232", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7575889"}], "notes": [], "created": "2020-11-26T12:18:33.090Z", "modified": "2020-11-27T11:47:58.870Z"}, {"entity": "publication", "iuid": "22808e8b71744f5eaceaef8395f820f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/22808e8b71744f5eaceaef8395f820f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/22808e8b71744f5eaceaef8395f820f2"}}, "title": "A population-based nationwide dataset concerning the COVID-19 pandemic and serious psychological consequences in Bangladesh", "authors": [{"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Al Mamun", "given": "Firoj", "initials": "F"}, {"family": "Hosen", "given": "Ismail", "initials": "I"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "Data Brief", "issn": "2352-3409", "volume": "33", "issue": null, "pages": "106621", "issn-l": null}, "abstract": "This paper presents the dataset concerning knowledge, preventive behavior, psychological consequences, and suicidal behavior regarding the COVID-19 pandemic in Bangladesh. Data were collected through an online based cross-sectional survey between April 1 and April 10 in 64 districts at the early stage of the COVID-19 pandemic in Bangladesh. A total of 10,067 participants' data were recruited for analysis. The survey contained items concerning (i) socio-demographic information, (ii) knowledge concerning COVID-19, (iii) behavior towards COVID-19, (iv) lockdown and economic issues, (v) assessment of fear of COVID-19, (vi) assessment of insomnia, (vii) assessment of depression, and (viii) assessment of suicidal ideation. Data were analyzed utilizing SPSS (version 22) and are represented as frequencies and percentages based on responses to the whole survey. Given that the data were collected across the whole nation, government authorities and healthcare policymakers can use the data to develop various models and/or policies regarding preventive strategies and help raise awareness through health education towards COVID-19.", "doi": "10.1016/j.dib.2020.106621", "pmid": "33344737", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.7910/DVN/YKH9C1", "description": "Raw dataset: socio-demographic characteristics, sources of information regarding COVID-19, knowledge concerning COVID-19, behavior in preventing COVID-19, etc. (N=10,067)"}, {"db": "URL", "key": "https://ars.els-cdn.com/content/image/1-s2.0-S2352340920315018-mmc1.docx", "description": "Detailed description of all study variables"}], "notes": [], "created": "2021-01-08T08:32:42.091Z", "modified": "2021-02-26T08:46:59.856Z"}, {"entity": "publication", "iuid": "a887d824552b43858617ee072044d692", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a887d824552b43858617ee072044d692.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a887d824552b43858617ee072044d692"}}, "title": "The Precision Health and Everyday Democracy (PHED) Project: Protocol for a Transdisciplinary Collaboration on Health Equity and the Role of Health in Society.", "authors": [{"family": "Strange", "given": "Michael", "initials": "M"}, {"family": "Nilsson", "given": "Carol", "initials": "C"}, {"family": "Zdravkovic", "given": "Slobodan", "initials": "S"}, {"family": "Mangrio", "given": "Elisabeth", "initials": "E"}], "type": "journal article", "published": "2020-11-30", "journal": {"title": "JMIR Res Protoc", "issn": "1929-0748", "volume": "9", "issue": "11", "pages": "e17324", "issn-l": null}, "abstract": "The project \"Precision Health and Everyday Democracy\" (PHED) is a transdisciplinary partnership that combines a diverse range of perspectives necessary for understanding the increasingly complex societal role played by modern health care and medical research. The term \"precision health\" is being increasingly used to express the need for greater awareness of environmental and genomic characteristics that may lead to divergent health outcomes between different groups within a population. Enhancing awareness of diversity has parallels with calls for \"health democracy\" and greater patient-public participation within health care and medical research. Approaching health care in this way goes beyond a narrow focus on the societal determinants of health, since it requires considering health as a deliberative space, which occurs often at the banal or everyday level. As an initial empirical focus, PHED is directed toward the health needs of marginalized migrants (including refugees and asylum seekers, as well as migrants with temporary residency, often involving a legally or economically precarious situation) as vulnerable groups that are often overlooked by health care. Developing new transdisciplinary knowledge on these groups provides the potential to enhance their wellbeing and benefit the wider society through challenging the exclusions of these groups that create pockets of extreme ill-health, which, as we see with COVID-19, should be better understood as \"acts of self-harm\" for the wider negative impact on humanity.\n\nWe aim to establish and identify precision health strategies, as well as promote equal access to quality health care, drawing upon knowledge gained from studying the health care of marginalized migrants.\n\nThe project is based in Sweden at Malm\u00f6 and Lund Universities. At the outset, the network activities do not require ethical approval where they will not involve data collection, since the purpose of PHED is to strengthen international research contacts, establish new research within precision strategies, and construct educational research activities for junior colleagues within academia. However, whenever new research is funded and started, ethical approval for that specific data collection will be sought.\n\nThe PHED project has been funded from January 1, 2019. Results of the transdisciplinary collaboration will be disseminated via a series of international conferences, workshops, and web-based materials. To ensure the network project advances toward applied research, a major goal of dissemination is to produce tools for applied research, including information to enhance health accessibility for vulnerable communities, such as marginalized migrant populations in Sweden.\n\nThere is a need to identify tools to enable the prevention and treatment of a wide spectrum of health-related outcomes and their link to social as well as environmental issues. There is also a need to identify and investigate barriers to precision health based on democratic principles.\n\nDERR1-10.2196/17324.", "doi": "10.2196/17324", "pmid": "33252352", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "v9i11e17324"}], "notes": [], "created": "2020-12-03T08:24:10.169Z", "modified": "2020-12-03T08:24:10.192Z"}, {"entity": "publication", "iuid": "9159f26c8905426ba3599eaf2c635be2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9159f26c8905426ba3599eaf2c635be2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9159f26c8905426ba3599eaf2c635be2"}}, "title": "The COVID-19 pandemic: consequences for nephrology.", "authors": [{"family": "Bruchfeld", "given": "Annette", "initials": "A"}], "type": "journal article", "published": "2020-11-30", "journal": {"title": "Nat Rev Nephrol", "issn": "1759-507X", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1038/s41581-020-00381-4", "pmid": "33257872", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41581-020-00381-4"}], "notes": [], "created": "2020-12-03T08:18:19.455Z", "modified": "2020-12-03T08:18:19.476Z"}, {"entity": "publication", "iuid": "7aeabc3750d1481bb578d56cb544837a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7aeabc3750d1481bb578d56cb544837a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7aeabc3750d1481bb578d56cb544837a"}}, "title": "Rapid review of suspected adverse drug events due to remdesivir in the WHO database; findings and implications.", "authors": [{"family": "Charan", "given": "Jaykaran", "initials": "J"}, {"family": "Kaur", "given": "Rimple Jeet", "initials": "RJ"}, {"family": "Bhardwaj", "given": "Pankaj", "initials": "P"}, {"family": "Haque", "given": "Mainul", "initials": "M"}, {"family": "Sharma", "given": "Praveen", "initials": "P"}, {"family": "Misra", "given": "Sanjeev", "initials": "S"}, {"family": "Godman", "given": "Brian", "initials": "B"}], "type": "journal article", "published": "2020-11-30", "journal": {"title": "Expert Rev Clin Pharmacol", "issn": "1751-2441", "volume": null, "issue": null, "issn-l": null}, "abstract": "Objectives: Remdesivir has shown promise in the management of patients with COVID-19 although recent studies have shown concerns with its effectiveness in practice. Despite this there is a need to document potential adverse drug events (ADEs) to guide future decisions as limited ADE data available before COVID-19 pandemic. Methods: Interrogation of WHO VigiBase\u00ae from 2015 to 2020 coupled with published studies of ADEs in COVID-19 patients. The main outcome measures are the extent of ADEs broken down by factors including age, seriousness, region and organ. Results: A total 1086 ADEs were reported from the 439 individual case reports up to 19 July 2020 in the VigiBase\u00ae, reduced to 1004 once duplicates were excluded. Almost all ADEs concerned COVID-19 patients (92.5%), with an appreciable number from the Americas (67.7%). The majority of ADEs were from males > 45 years and were serious (82.5%). An increase in hepatic enzymes (32.1%), renal injury (14.4%), rise in creatinine levels (11.2%) respiratory failure (6.4%) were the most frequently reported ADEs. Conclusions: Deterioration of liver and kidney function are frequently observed ADEs with remdesivir; consequently, patients should be monitored for these ADEs. The findings are in line with ADEs included in regulatory authority documents.", "doi": "10.1080/17512433.2021.1856655", "pmid": "33252992", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-12-03T08:22:50.485Z", "modified": "2020-12-03T08:22:50.508Z"}, {"entity": "publication", "iuid": "647022ddc42941beab3d22a7d0a54b73", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/647022ddc42941beab3d22a7d0a54b73.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/647022ddc42941beab3d22a7d0a54b73"}}, "title": "Intracerebral endotheliitis and microbleeds are neuropathological features of COVID-19.", "authors": [{"family": "Kirschenbaum", "given": "Daniel", "initials": "D"}, {"family": "Imbach", "given": "Lukas L", "initials": "LL"}, {"family": "Jane Rushing", "given": "Elisabeth", "initials": "E"}, {"family": "Frauenknecht", "given": "Katrin B M", "initials": "KBM"}, {"family": "Gascho R T", "given": "Dominic", "initials": "D"}, {"family": "Victor Ineichen", "given": "Benjamin", "initials": "B"}, {"family": "Keller", "given": "Emanuela", "initials": "E"}, {"family": "Kohler", "given": "Sibylle", "initials": "S"}, {"family": "Lichtblau", "given": "Mona", "initials": "M"}, {"family": "Reimann", "given": "Regina R", "initials": "RR"}, {"family": "Schreib", "given": "Katharina", "initials": "K"}, {"family": "Ulrich", "given": "Silvia", "initials": "S"}, {"family": "Steiger", "given": "Peter", "initials": "P"}, {"family": "Aguzzi", "given": "Adriano", "initials": "A"}, {"family": "Frontzek", "given": "Karl", "initials": "K"}], "type": "journal article", "published": "2020-11-29", "journal": {"title": "Neuropathol Appl Neurobiol", "issn": "1365-2990", "volume": null, "issue": null, "issn-l": null}, "abstract": "Coronavirus disease 19 (COVID-19), caused by infection with the severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2), has become a worldwide pandemic (1). Symptoms of COVID-19 vary widely and range from asymptomatic disease to severe pneumonia and multiorgan failure (2). A severe disease course is more likely in older patients and patients with pre-existing respiratory and cardiovascular conditions (2). Patients with severe Sars-CoV-2 infection may present with ischaemic stroke (3, 4) or even fatal intracerebral haemorrhage (5). To date, little is known about the neuropathological sequelae of COVID-19. The largest published autopsy series of COVID-19 neuropathology reported microthrombi and acute haemorrhagic infarction in a significant number of patients (6), while another more recent study found evidence of lymphocytic encephalitis and meningitis (7). Endotheliitis of the brain and extraneural organs has been shown in Sars-CoV infected patients (8). Similarly, it is a recurrent feature in the lungs and other peripheral organs of Sars-CoV-2 infected patients (9) but has not yet been reported in the central nervous system. We speculated that cerebrovascular pathology in COVID-19 patients could be a direct consequence of hitherto unidentified cerebral endotheliitis caused by Sars-CoV-2.", "doi": "10.1111/nan.12677", "pmid": "33249605", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Provided in the article: Clinical and pathological characteristics of four patients", "description": null}], "notes": [], "created": "2020-11-30T07:48:09.681Z", "modified": "2021-02-26T08:45:48.255Z"}, {"entity": "publication", "iuid": "6c4ea2411cc242ddb5a2d67e6bbbf015", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c4ea2411cc242ddb5a2d67e6bbbf015.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c4ea2411cc242ddb5a2d67e6bbbf015"}}, "title": "The impact of COVID-19 pandemic on pornography habits: a global analysis of Google Trends.", "authors": [{"family": "Zattoni", "given": "Fabio", "initials": "F"}, {"family": "G\u00fcl", "given": "Murat", "initials": "M"}, {"family": "Soligo", "given": "Matteo", "initials": "M"}, {"family": "Morlacco", "given": "Alessandro", "initials": "A"}, {"family": "Motterle", "given": "Giovanni", "initials": "G"}, {"family": "Collavino", "given": "Jeanlou", "initials": "J"}, {"family": "Barneschi", "given": "Andrea Celeste", "initials": "AC"}, {"family": "Moschini", "given": "Marco", "initials": "M"}, {"family": "Moro", "given": "Fabrizio Dal", "initials": "FD"}], "type": "journal article", "published": "2020-11-28", "journal": {"title": "Int J Impot Res", "issn": "1476-5489", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "As the COVID-19 spread globally, social distancing, self-isolation/quarantine, and national lockdowns have become crucial to control the pandemic. However, these measures may also lead to increases in social isolation, loneliness, and stress, which can alter the consumption of pornography habits. The aim of the study was thus to explore the interest pattern in pornography and coronavirus-themed pornography during the COVID-19 outbreak. Google Trends\u00ae was employed to determine the most popular porn websites (Porn, XNXX, PornHub, xVideos, and xHamster), and coronavirus-themed pornography worldwide and in six nations with different COVID-19 outbreak and self-isolation recommendations. We analyzed every search trend on Google\u00ae from January 9, 2020 to May 25, 2020 using \"joint point regression analysis\". Comparisons of week relative search volume (WRSV) and temporal patterns were analyzed to assess the change of interest in search terms during nations lockdowns. Paired t-test was used to compare WRSV values among the porn websites during the national lockdowns and the equivalent timespan of the weeks in the previous 4 years. The research trend of almost every keyword increased with significant inflection points for those nations with a straight \"stay at home orders\" (China, Italy, Spain, and France). \"PornHub\" and \"Porn\" showed the highest increase of interest worldwide with an average weekend percentage change (AWPC) of 4.9 and 3.8, respectively. The mean WRSV for keywords in USA and Sweden did not show a similar increase as the other nations. The WRSV percentage change with the historical data had a peak during the straight nations' lockdowns (p < 0.01). All the nations had a significant increase in WRSV coronavirus-themed pornography for each keyword (p < 0.01) with an AWPC, ranging worldwide between 18.5 and 61.8 (p < 0.01), after the beginning of self-quarantine. As strengths this study uses a big data technology to collect worldwide trend of interest, however, data are anonymous and do not allow analysis of subpopulation groups. In conclusion, we demonstrated an increased interest in pornography and coronavirus-themed pornography after the outbreak of COVID-19 in nations with a straight \"stay at home orders\".", "doi": "10.1038/s41443-020-00380-w", "pmid": "33249423", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2020-11-30T07:47:06.936Z", "modified": "2022-11-23T09:04:21.537Z"}, {"entity": "publication", "iuid": "a3c83a5854494d38acd58145a9a305c6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3c83a5854494d38acd58145a9a305c6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3c83a5854494d38acd58145a9a305c6"}}, "title": "Written Emotional Disclosure Can Promote Athletes' Mental Health and Performance Readiness During the COVID-19 Pandemic.", "authors": [{"family": "Davis", "given": "Paul A", "initials": "PA"}, {"family": "Gustafsson", "given": "Henrik", "initials": "H"}, {"family": "Callow", "given": "Nichola", "initials": "N"}, {"family": "Woodman", "given": "Tim", "initials": "T"}], "type": "journal article", "published": "2020-11-27", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "11", "issue": null, "pages": "599925", "issn-l": "1664-1078"}, "abstract": "The widespread effects of the coronavirus disease 2019 (COVID-19) pandemic have negatively impacted upon many athletes' mental health and increased reports of depression as well as symptoms of anxiety. Disruptions to training and competition schedules can induce athletes' emotional distress, while concomitant government-imposed restrictions (e.g., social isolation, quarantines) reduce the availability of athletes' social and emotional support. Written Emotional Disclosure (WED) has been used extensively in a variety of settings with diverse populations as a means to promote emotional processing. The expressive writing protocol has been used to a limited extent in the context of sport and predominantly in support of athletes' emotional processing during injury rehabilitation. We propose that WED offers an evidence-based treatment that can promote athletes' mental health and support their return to competition. Research exploring the efficacy of the expressive writing protocol highlights a number of theoretical models underpinning the positive effects of WED; we outline how each of these potential mechanisms can address the multidimensional complexity of the challenging circumstances arising from the COVID-19 pandemic (e.g., loss of earnings, returning to training and competition). Considerations and strategies for using WED to support athletes during the COVID-19 pandemic are presented.", "doi": "10.3389/fpsyg.2020.599925", "pmid": "33329269", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7728796"}], "notes": [], "created": "2020-12-21T09:03:40.504Z", "modified": "2021-01-10T18:12:49.509Z"}, {"entity": "publication", "iuid": "f2778adcd2b944c7983e61fdd7315dbf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f2778adcd2b944c7983e61fdd7315dbf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f2778adcd2b944c7983e61fdd7315dbf"}}, "title": "Mental health of Urban Mothers (MUM) study: a multicentre randomised controlled trial, study protocol.", "authors": [{"family": "Schwank", "given": "Simone Eliane", "initials": "SE"}, {"family": "Chung", "given": "Ho-Fung", "initials": "H"}, {"family": "Hsu", "given": "Mandy", "initials": "M"}, {"family": "Fu", "given": "Shih-Chien", "initials": "S"}, {"family": "Du", "given": "Li", "initials": "L"}, {"family": "Zhu", "given": "Liping", "initials": "L"}, {"family": "Huang", "given": "Hsuan-Ying", "initials": "H"}, {"family": "Andersson", "given": "Ewa", "initials": "E"}, {"family": "Acharya", "given": "Ganesh", "initials": "G"}], "type": "journal article", "published": "2020-11-27", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "10", "issue": "11", "pages": "e041133"}, "abstract": "Mental health disorders are common during pregnancy and the postnatal period and can have serious adverse effects on women and their children. The consequences for global mental health due to COVID-19 are likely to be significant and may have a long-term impact on the global burden of disease. Besides physical vulnerability, pregnant women are at increased risk of mental health problems such as anxiety, depression and post-traumatic stress disorder due to the consequences of social distancing. It can result in altered healthcare routines, less support from the family and friends, and in some cases, partners not being allowed to be present during prenatal visits, labour and delivery. Higher than expected, rates of perinatal anxiety and depression have been already reported during the pandemic. Pregnant women may also feel insecure and worried about the effects of COVID-19 on their unborn child if they get infected during pregnancy. Today, young urban women are used to using internet services frequently and efficiently. Therefore, providing mental health support to pregnant women via internet may be effective in ameliorating their anxiety/depression, reducing the risk of serious mental health disorders, and lead to improved maternal and perinatal outcomes.\r\n\r\nOur aim is to explore the effectiveness of a web-based psychosocial peer-to-peer support intervention in reducing the risk and severity of perinatal mental health disorders and preventing adverse pregnancy outcomes among pregnant women living in metropolitan urban settings.\r\n\r\nWe plan to conduct a multicentre prospective randomised controlled trial, Mental health of Urban Mothers trial. Pregnant women living in large metropolitan cities will be recruited using internet-based application through non-profit organisations' websites. The women who consent will be randomised to receive a web-based peer-to-peer support intervention or usual care. Data will be analysed to identify the effects of intervention on Edinburgh Postnatal Depression Score and Generalised Anxiety Disorder 7 scores as well as pregnancy outcomes. The impact of COVID-19 pandemic on maternal stress will be assesed using Impact Event Scale-R. Any differences in outcomes between cities will be addressed in subgroup analyses.\r\n\r\nThe study will be conducted according to the principles of Good Clinical Practice and will follow the ethical principles of the Declaration of Helsinki. The study protocol has been approved by the ethical review board of Chinese University of Hong Kong (IRB number 2019-8170) and Shanghai Center for Women's and Children's Health (international review board (IRB) number 2020-F001-12). The results will be disseminated at national and international scientific conferences, published in peer-reviewed medical journals and spread to the public through social media, news outlets and podcasts.\r\n\r\nNCT04363177; Trial sponsor Karolinska Institute, CLINTEC, Stockholm, Sweden.", "doi": "10.1136/bmjopen-2020-041133", "pmid": "33247023", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT04363177"}], "notes": [], "created": "2020-11-30T07:46:40.493Z", "modified": "2021-02-26T08:47:00.311Z"}, {"entity": "publication", "iuid": "8dd348ce456d47c79151aec5347fef0a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8dd348ce456d47c79151aec5347fef0a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8dd348ce456d47c79151aec5347fef0a"}}, "title": "Covid-19: What Sweden taught Scandinavia for the second wave.", "authors": [{"family": "Habib", "given": "Heba", "initials": "H"}], "type": "journal article", "published": "2020-11-27", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "371", "issue": null, "pages": "m4456", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m4456", "pmid": "33246990", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-30T07:45:48.902Z", "modified": "2020-11-30T07:45:48.924Z"}, {"entity": "publication", "iuid": "c9fdf08396a04e9cb5089bc451fd64b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9fdf08396a04e9cb5089bc451fd64b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9fdf08396a04e9cb5089bc451fd64b0"}}, "title": "Deciphering the ins and outs of SARS-CoV-2-specific T cells.", "authors": [{"family": "Perez-Potti", "given": "Andr\u00e9", "initials": "A"}, {"family": "Lange", "given": "Joshua", "initials": "J"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}], "type": "journal article", "published": "2020-11-26", "journal": {"title": "Nat Immunol", "issn": "1529-2916", "issn-l": null, "volume": "22", "issue": "1", "pages": "8-9"}, "abstract": null, "doi": "10.1038/s41590-020-00838-5", "pmid": "33244183", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41590-020-00838-5"}], "notes": [], "created": "2020-12-04T08:40:41.685Z", "modified": "2021-01-25T13:09:05.326Z"}, {"entity": "publication", "iuid": "1267273983384e4a85c6c81599143317", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1267273983384e4a85c6c81599143317.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1267273983384e4a85c6c81599143317"}}, "title": "Could Naturally Occurring Coronaviral Diseases in Animals Serve as Models for COVID-19? A Review Focusing on the Bovine Model.", "authors": [{"family": "Wensman", "given": "Jonas Johansson", "initials": "JJ"}, {"family": "Stokstad", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2020-11-26", "journal": {"title": "Pathogens", "issn": "2076-0817", "volume": "9", "issue": "12", "issn-l": "2076-0817"}, "abstract": "The current pandemic of COVID-19 has highlighted the importance of basic studies on coronaviruses (CoVs) in general, and severe acute respiratory syndrome CoV type 2 (SARS-CoV-2) in particular. CoVs have for long been studied in veterinary medicine, due to their impact on animal health and welfare, production, and economy. Several animal models using coronaviral disease in the natural host have been suggested. In this review, different animal models are discussed, with the main focus on bovine CoV (BCoV). BCoV is endemic in the cattle population worldwide and has been known and studied for several decades. SARS-CoV-2 and BCoV are both betacoronaviruses, where BCoV is highly similar to human coronavirus (HCoV) OC43, encompassing the same virus species ( Betacoronavirus 1). BCoV causes respiratory and gastrointestinal disease in young and adult cattle. This review summarizes the current knowledge of the similarities and dissimilarities between BCoV and SARS-CoV-2, as well as discussing the usage of BCoV as a model for human CoVs, including SARS-CoV-2.", "doi": "10.3390/pathogens9120991", "pmid": "33256111", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "pathogens9120991"}], "notes": [], "created": "2020-12-03T08:19:17.049Z", "modified": "2020-12-03T08:19:17.059Z"}, {"entity": "publication", "iuid": "3210460c33c34c7ea185651a27581b00", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3210460c33c34c7ea185651a27581b00.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3210460c33c34c7ea185651a27581b00"}}, "title": "Controlling the Outbreak of COVID-19: A Noncooperative Game Perspective.", "authors": [{"family": "Bairagi", "given": "Anupam Kumar", "initials": "AK"}, {"family": "Masud", "given": "Mehedi", "initials": "M"}, {"family": "Kim", "given": "Do Hyeon", "initials": "DH"}, {"family": "Munir", "given": "Md Shirajum", "initials": "MS"}, {"family": "Nahid", "given": "Abdullah-Al", "initials": "AA"}, {"family": "Abedin", "given": "Sarder Fakhrul", "initials": "SF"}, {"family": "Alam", "given": "Kazi Masudul", "initials": "KM"}, {"family": "Biswas", "given": "Sujit", "initials": "S"}, {"family": "Alshamrani", "given": "Sultan S", "initials": "SS"}, {"family": "Han", "given": "Zhu", "initials": "Z"}, {"family": "Hong", "given": "Choong Seon", "initials": "CS"}], "type": "journal article", "published": "2020-11-26", "journal": {"title": "IEEE Access", "issn": "2169-3536", "volume": "8", "pages": "215570-215581", "issn-l": null}, "abstract": "COVID-19 is a global epidemic. Till now, there is no remedy for this epidemic. However, isolation and social distancing are seemed to be effective preventive measures to control this pandemic. Therefore, in this article, an optimization problem is formulated that accommodates both isolation and social distancing features of the individuals. To promote social distancing, we solve the formulated problem by applying a noncooperative game that can provide an incentive for maintaining social distancing to prevent the spread of COVID-19. Furthermore, the sustainability of the lockdown policy is interpreted with the help of our proposed game-theoretic incentive model for maintaining social distancing where there exists a Nash equilibrium. Finally, we perform an extensive numerical analysis that shows the effectiveness of the proposed approach in terms of achieving the desired social-distancing to prevent the outbreak of the COVID-19 in a noncooperative environment. Numerical results show that the individual incentive increases more than 85% with an increasing percentage of home isolation from 25% to 100% for all considered scenarios. The numerical results also demonstrate that in a particular percentage of home isolation, the individual incentive decreases with an increasing number of individuals.", "doi": "10.1109/ACCESS.2020.3040821", "pmid": "34812371", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8545264"}], "notes": [], "created": "2021-11-26T13:23:59.524Z", "modified": "2021-12-10T18:00:17.736Z"}, {"entity": "publication", "iuid": "b8f7c179d4c84272b7105c32a99b99ec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8f7c179d4c84272b7105c32a99b99ec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8f7c179d4c84272b7105c32a99b99ec"}}, "title": "Beginning of the Pandemic: COVID-19-Elicited Anxiety as a Predictor of Working Memory Performance.", "authors": [{"family": "Fellman", "given": "Daniel", "initials": "D"}, {"family": "Ritakallio", "given": "Liisa", "initials": "L"}, {"family": "Waris", "given": "Otto", "initials": "O"}, {"family": "Jylkk\u00e4", "given": "Jussi", "initials": "J"}, {"family": "Laine", "given": "Matti", "initials": "M"}], "type": "journal article", "published": "2020-11-26", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "11", "issue": null, "pages": "576466"}, "abstract": "Increasing evidence indicates that the coronavirus disease 2019 (COVID-19) pandemic is associated with adverse psychological effects, including heightened levels of anxiety. This study examined whether COVID-19-related anxiety levels during the early stage of the pandemic predicted demanding working memory (WM) updating performance. Altogether, 201 healthy adults (age range, 18-50) mostly from North America and the British Isles were recruited to this study via the crowdsourcing site www.prolific.co. The results showed that higher levels of COVID-19-related anxiety during the first weeks of the pandemic outbreak were associated with poorer WM performance as measured by the n-back paradigm. Critically, the unique role of COVID-19-related anxiety on WM could not be explained by demographic factors, or other psychological factors such as state and trait anxiety or fluid intelligence. Moreover, across three assessment points spanning 5-6 weeks, COVID-19-related anxiety levels tended to decrease over time. This pattern of results may reflect an initial psychological \"shock wave\" of the pandemic, the cognitive effects of which may linger for some time, albeit the initial anxiety associated with the pandemic would change with habituation and increasing information. Our results contribute to the understanding of cognitive-affective reactions to a major disaster.", "doi": "10.3389/fpsyg.2020.576466", "pmid": "33324288", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7725684"}, {"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-12-21T09:04:37.394Z", "modified": "2021-02-26T08:47:00.173Z"}, {"entity": "publication", "iuid": "d988eec958034f74b9cd5ea1eb00c0be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d988eec958034f74b9cd5ea1eb00c0be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d988eec958034f74b9cd5ea1eb00c0be"}}, "title": "Trading Health for Wealth: The Effect of COVID-19 Response Stringency.", "authors": [{"family": "Cross", "given": "Megan", "initials": "M"}, {"family": "Ng", "given": "Shu-Kay", "initials": "SK"}, {"family": "Scuffham", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2020-11-24", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "17", "issue": "23", "issn-l": null}, "abstract": "International governments' COVID-19 responses must balance human and economic health. Beyond slowing viral transmission, strict lockdowns have severe economic consequences. This work investigated response stringency, quantified by the Oxford COVID-19 Government Response Tracker's Stringency Index, and examined how restrictive interventions affected infection rates and gross domestic product (GDP) in China and OECD countries. Accounting for response timing, China imposed the most stringent restrictions, while Sweden and Japan were the least stringent. Expected GDP declines range from -8% (Japan) to -15.4% (UK). While greater restrictions generally slowed viral transmission, they failed to reach statistical significance and reduced GDP ( p = 0.006). Timing was fundamental: governments who responded to the pandemic faster saw greater reductions in viral transmission (p = 0.013), but worse decreases in GDP (p = 0.044). Thus, response stringency has a greater effect on GDP than infection rates, which are instead affected by the timing of COVID-19 interventions. Attempts to mitigate economic impacts by delaying restrictions or decreasing stringency may buoy GDP in the short term but increase infection rates, the longer-term economic consequences of which are not yet fully understood. As highly restrictive interventions were successful in some but not all countries, decision-makers must consider whether their strategies are appropriate for the country on health and economic grounds.", "doi": "10.3390/ijerph17238725", "pmid": "33255383", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph17238725"}], "notes": [], "created": "2020-12-03T08:18:31.993Z", "modified": "2020-12-03T08:18:32.007Z"}, {"entity": "publication", "iuid": "0512e611adbe4166a1cc2ff5dee38f98", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0512e611adbe4166a1cc2ff5dee38f98.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0512e611adbe4166a1cc2ff5dee38f98"}}, "title": "Social Determinants Predict Outcomes in Data From a Multi-Ethnic Cohort of 20,899 Patients Investigated for COVID-19.", "authors": [{"family": "Lundon", "given": "Dara J", "initials": "DJ"}, {"family": "Mohamed", "given": "Nihal", "initials": "N"}, {"family": "Lantz", "given": "Anna", "initials": "A"}, {"family": "Goltz", "given": "Heather H", "initials": "HH"}, {"family": "Kelly", "given": "Brian D", "initials": "BD"}, {"family": "Tewari", "given": "Ashutosh K", "initials": "AK"}], "type": "journal article", "published": "2020-11-24", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "8", "issue": null, "pages": "571364"}, "abstract": "Importance: The COVID-19 pandemic exploits existing inequalities in social determinants of health (SDOH) in disease burden and access to healthcare. Few studies have examined these emerging disparities using indicators of SDOH. Objective: To evaluate predictors of COVID-19 test positivity, morbidity, and mortality and their implications for inequalities in SDOH and for future policies and health care improvements. Design, Setting, and Participants: A cross sectional analysis was performed on all patients tested for COVID-19 on the basis of symptoms with either a history of travel to at risk regions or close contact with a confirmed case, across the Mount Sinai Health System (MSHS) up until April 26th 2020. Main Outcomes and Measures: Primary outcome was death from COVID-19 and secondary outcomes were test positivity, and morbidity (e.g., hospitalization and intubation caused by COVID-19). Results: Of 20,899 tested patients, 8,928 tested positive, 1,701 were hospitalized, 684 were intubated, and 1,179 died from COVID-19. Age, sex, race/ethnicity, New York City borough (derived from first 3 digits of zip-code), and English as preferred language were significant predictors of test positivity, hospitalization, intubation and COVID-19 mortality following multivariable logistic regression analyses. Conclusions and Relevance: People residing in poorer boroughs were more likely to be burdened by and die from COVID-19. Our results highlight the importance of integrating comprehensive SDOH data into healthcare efforts with at-risk patient populations.", "doi": "10.3389/fpubh.2020.571364", "pmid": "33324596", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7722480"}, {"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-12-21T10:01:18.157Z", "modified": "2021-02-26T08:46:59.802Z"}, {"entity": "publication", "iuid": "4f8deeb9b8fc4cb9ab821eb4ea8fe0e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4f8deeb9b8fc4cb9ab821eb4ea8fe0e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4f8deeb9b8fc4cb9ab821eb4ea8fe0e1"}}, "title": "Low rate of COVID-19 seroconversion in health-care workers at a Department of Infectious Diseases in Sweden during the later phase of the first wave; a prospective longitudinal seroepidemiological study.", "authors": [{"family": "Rashid-Abdi", "given": "Mulki", "initials": "M"}, {"family": "Krifors", "given": "Anders", "initials": "A"}, {"family": "S\u00e4ll\u00e9ber", "given": "Andreas", "initials": "A"}, {"family": "Eriksson", "given": "Jenny", "initials": "J"}, {"family": "M\u00e5nsson", "given": "Emeli", "initials": "E"}], "type": "journal article", "published": "2020-11-24", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "volume": null, "issue": null, "pages": "1-7", "issn-l": "2374-4235"}, "abstract": "Background: Health-care workers are at risk of contracting and transmitting SARS-CoV-2. The aim of this study was to investigate the prevalence of SARS-CoV-2 IgG antibodies and the rate of seroconversion in an environment with high exposure to SARS-CoV-2. Methods: 131 health-care workers at the Department of Infectious Diseases in V\u00e4ster\u00e5s, Sweden, were included in the study. Abbott's SARS-COV-2 IgG immunoassay was used with a signal cut-off ratio of \u22651.4. Every third week from the beginning of May, blood samples were drawn, and the participants completed a questionnaire regarding symptoms consistent with COVID-19 and the result of any SARS-CoV-2 PCR performed since the last sampling occasion. Participants with IgG antibodies against SARS-CoV-2 were re-sampled only on the sixth and last occasion. Results: At the start of the study, 18 (15%) participants had SARS-CoV-2 IgG antibodies. At the end, 25 (19%) of 131 participants were seropositive. One case of asymptomatic infection was detected, and two cases with PCR-confirmed COVID-19 did not develop IgG antibodies. Conclusion: The low rate of seroconversion during the study suggests that it is possible to prevent transmission of SARS-COV-2 in a high-exposure environment. Compliance with adequate infection control guidelines is the likely explanation of our findings.", "doi": "10.1080/23744235.2020.1849787", "pmid": "33232190", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-26T14:15:35.168Z", "modified": "2021-02-26T08:45:48.126Z"}, {"entity": "publication", "iuid": "13bdf06c2df94e9796f3ce40cb2ada46", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13bdf06c2df94e9796f3ce40cb2ada46.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13bdf06c2df94e9796f3ce40cb2ada46"}}, "title": "How to ensure we can track and trace global use of COVID-19 vaccines?", "authors": [{"family": "Vander Stichele", "given": "Robert H", "initials": "RH"}, {"family": "Hay", "given": "Christian", "initials": "C"}, {"family": "Fladvad", "given": "Malin", "initials": "M"}, {"family": "Sturkenboom", "given": "Miriam C J M", "initials": "MCJM"}, {"family": "Chen", "given": "Robert T", "initials": "RT"}], "type": "journal article", "published": "2020-11-24", "journal": {"title": "Vaccine", "issn": "1873-2518", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.vaccine.2020.11.055", "pmid": "33293161", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(20)31508-5"}], "notes": [], "created": "2020-12-10T09:10:46.004Z", "modified": "2020-12-10T09:13:26.443Z"}, {"entity": "publication", "iuid": "aa777d31f46b4cf9948c95629e70bdf4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aa777d31f46b4cf9948c95629e70bdf4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aa777d31f46b4cf9948c95629e70bdf4"}}, "title": "Excess mortality across regions of Europe during the first wave of the COVID-19 pandemic \u2013 impact of the winter holiday travelling and government responses", "authors": [{"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}, {"family": "Mattisson", "given": "Kristoffer", "initials": "K"}, {"family": "Ahlbom", "given": "Anders", "initials": "A"}], "type": "posted-content", "published": "2020-11-24", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.11.24.20237644", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-10T04:20:55.285Z", "modified": "2021-06-10T04:22:34.266Z"}, {"entity": "publication", "iuid": "8d08457dded94192bbd8f026ed52f527", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d08457dded94192bbd8f026ed52f527.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d08457dded94192bbd8f026ed52f527"}}, "title": "At the Epicenter of COVID-19-the Tragic Failure of the Global Supply Chain for Medical Supplies.", "authors": [{"family": "Bhaskar", "given": "Sonu", "initials": "S"}, {"family": "Tan", "given": "Jeremy", "initials": "J"}, {"family": "Bogers", "given": "Marcel L A M", "initials": "MLAM"}, {"family": "Minssen", "given": "Timo", "initials": "T"}, {"family": "Badaruddin", "given": "Hishamuddin", "initials": "H"}, {"family": "Israeli-Korn", "given": "Simon", "initials": "S"}, {"family": "Chesbrough", "given": "Henry", "initials": "H"}], "type": "journal article", "published": "2020-11-24", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "562882", "issn-l": "2296-2565"}, "abstract": "The tragic failure of the global supply chain in the face of the current coronavirus outbreak has caused acute shortages of essential frontline medical devices and personal protective equipment, crushing fear among frontline health workers and causing fundamental concerns about the sustainability of the health system. Much more coordination, integration, and management of global supply chains will be needed to mitigate the impact of the pandemics. This article describes the pressing need to revisit the governance and resilience of the supply chains that amplified the crisis at pandemic scale. We propose a model that profiles critical stockpiles and improves production efficiency through new technologies such as advanced analytics and blockchain. A new governance system that supports intervention by public-health authorities during critical emergencies is central to our recommendation, both in the face of the current crisis and to be better prepared for potential future crises. These reinforcements offer the potential to minimize the compromise of our healthcare workers and health systems due to infection exposure and build capacity toward preparedness and action for a future outbreak.", "doi": "10.3389/fpubh.2020.562882", "pmid": "33335876", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7737425"}], "notes": [], "created": "2020-12-21T08:55:50.003Z", "modified": "2021-01-10T18:09:54.149Z"}, {"entity": "publication", "iuid": "3ac4c61ae4da4f789cec2d9a7448d388", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ac4c61ae4da4f789cec2d9a7448d388.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ac4c61ae4da4f789cec2d9a7448d388"}}, "title": "S\u00e5 har Sveriges coronastrategi framst\u00e5tt under \u00e5tta m\u00e5nader", "authors": [{"family": "F Ludvigsson", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2020-11-23", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": null, "doi": null, "pmid": "33230806", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "20188"}], "notes": [], "created": "2021-02-10T18:54:12.954Z", "modified": "2021-10-14T09:45:18.560Z"}, {"entity": "publication", "iuid": "9b858f8b0cb944f5ad94af6fda6c93b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b858f8b0cb944f5ad94af6fda6c93b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b858f8b0cb944f5ad94af6fda6c93b9"}}, "title": "Pore-Scale Transport and Two-Phase Fluid Structures in Fibrous Porous Layers: Application to Fuel Cells and Beyond.", "authors": [{"family": "Farzaneh", "given": "Meisam", "initials": "M"}, {"family": "Str\u00f6m", "given": "Henrik", "initials": "H"}, {"family": "Zanini", "given": "Filippo", "initials": "F"}, {"family": "Carmignato", "given": "Simone", "initials": "S"}, {"family": "Sasic", "given": "Srdjan", "initials": "S"}, {"family": "Maggiolo", "given": "Dario", "initials": "D"}], "type": "journal article", "published": "2020-11-23", "journal": {"title": "Transp Porous Media", "issn": "0169-3913", "volume": null, "issue": null, "pages": "1-26", "issn-l": null}, "abstract": "We present pore-scale simulations of two-phase flows in a reconstructed fibrous porous layer. The three-dimensional microstructure of the material, a fuel cell gas diffusion layer, is acquired via X-ray computed tomography and used as input for lattice Boltzmann simulations. We perform a quantitative analysis of the multiphase pore-scale dynamics, and we identify the dominant fluid structures governing mass transport. The results show the existence of three different regimes of transport: a fast inertial dynamics at short times, characterised by a compact uniform front, a viscous-capillary regime at intermediate times, where liquid is transported along a gradually increasing number of preferential flow paths of the size of one-two pores, and a third regime at longer times, where liquid, after having reached the outlet, is exclusively flowing along such flow paths and the two-phase fluid structures are stabilised. We observe that the fibrous layer presents significant variations in its microscopic morphology, which have an important effect on the pore invasion dynamics, and counteract the stabilising viscous force. Liquid transport is indeed affected by the presence of microstructure-induced capillary pressures acting adversely to the flow, leading to capillary fingering transport mechanism and unstable front displacement, even in the absence of hydrophobic treatments of the porous material. We propose a macroscopic model based on an effective contact angle that mimics the effects of the such a dynamic capillary pressure. Finally, we underline the significance of the results for the optimal design of face masks in an effort to mitigate the current COVID-19 pandemic.", "doi": "10.1007/s11242-020-01509-7", "pmid": "33250547", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "1509"}, {"db": "pmc", "key": "PMC7682777"}], "notes": [], "created": "2020-12-03T08:26:27.558Z", "modified": "2021-02-26T08:46:13.387Z"}, {"entity": "publication", "iuid": "5e0aca6899a0474ca133d3d6a9e52ec6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e0aca6899a0474ca133d3d6a9e52ec6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e0aca6899a0474ca133d3d6a9e52ec6"}}, "title": "Low prevalence of bloodstream infection and high blood culture contamination rates in patients with COVID-19.", "authors": [{"family": "Yu", "given": "David", "initials": "D"}, {"family": "Ininbergs", "given": "Karolina", "initials": "K"}, {"family": "Hedman", "given": "Karolina", "initials": "K"}, {"family": "Giske", "given": "Christian G", "initials": "CG"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "\u00d6zenci", "given": "Volkan", "initials": "V"}], "type": "journal article", "published": "2020-11-23", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "15", "issue": "11", "pages": "e0242533", "issn-l": "1932-6203"}, "abstract": "In the management of COVID-19, knowledge is lacking on the frequency of secondary bacterial infections and on how empirical antibiotic therapy should be used. In the present study, we aimed to compare blood culture (BC) results of a COVID-19 patient cohort with two cohorts of patients without detected COVID-19.\n\nUsing a retrospective cohort study design of patients subjected to BC in six tertiary care hospitals, SARS-CoV-2 positive patients from March 1 to April 30 in 2020 (COVID-19 group) were compared to patients without confirmed SARS-CoV-2 during the same period (control group-2020) and with patients sampled March 1 to April 30 in 2019 (control group-2019). The outcomes studied were proportion of BC positivity, clinically relevant growth, and contaminant growth.\n\nIn total 15,103 patients and 17,865 BC episodes were studied. Clinically relevant growth was detected in 197/3,027 (6.5%) BC episodes in the COVID-19 group compared to 717/6,663 (10.8%) in control group-2020 (p<0.0001) and 850/8,175 (10.4%) in control group-2019 (p<0.0001). Contamination was present in 255/3,027 (8.4%) BC episodes in the COVID-19 group compared to 330/6,663 (5.0%) in control group-2020 (p<0.0001) and 354/8,175 (4.3%) in control group-2019 (p<0.0001).\n\nIn COVID-19 patients, the prevalence of bloodstream bacterial infection is low and the contamination rate of BC is high. This knowledge should influence guidelines regarding blood culture sampling and empirical antibiotic therapy in COVID-19 patients.", "doi": "10.1371/journal.pone.0242533", "pmid": "33226995", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-20448"}], "notes": [], "created": "2020-11-26T14:17:26.847Z", "modified": "2021-02-26T08:45:48.234Z"}, {"entity": "publication", "iuid": "4c160f784d3e4ff1a016fabefbe69555", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4c160f784d3e4ff1a016fabefbe69555.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4c160f784d3e4ff1a016fabefbe69555"}}, "title": "Dosing of thromboprophylaxis and mortality in critically ill COVID-19 patients.", "authors": [{"family": "Jonmarker", "given": "Sandra", "initials": "S"}, {"family": "Hollenberg", "given": "Jacob", "initials": "J"}, {"family": "Dahlberg", "given": "Martin", "initials": "M"}, {"family": "Stackelberg", "given": "Otto", "initials": "O"}, {"family": "Litorell", "given": "Jacob", "initials": "J"}, {"family": "Everhov", "given": "\u00c5sa H", "initials": "\u00c5H"}, {"family": "J\u00e4rnbert-Pettersson", "given": "Hans", "initials": "H"}, {"family": "S\u00f6derberg", "given": "M\u00e5rten", "initials": "M"}, {"family": "Grip", "given": "Jonathan", "initials": "J"}, {"family": "Schandl", "given": "Anna", "initials": "A"}, {"family": "G\u00fcnther", "given": "Mattias", "initials": "M"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2020-11-23", "journal": {"title": "Crit Care", "issn": "1466-609X", "issn-l": "1364-8535", "volume": "24", "issue": "1", "pages": "653"}, "abstract": "A substantial proportion of critically ill COVID-19 patients develop thromboembolic complications, but it is unclear whether higher doses of thromboprophylaxis are associated with lower mortality rates. The purpose of the study was to evaluate the association between initial dosing strategy of thromboprophylaxis in critically ill COVID-19 patients and the risk of death, thromboembolism, and bleeding.\r\n\r\nIn this retrospective study, all critically ill COVID-19 patients admitted to two intensive care units in March and April 2020 were eligible. Patients were categorized into three groups according to initial daily dose of thromboprophylaxis: low (2500-4500 IU tinzaparin or 2500-5000 IU dalteparin), medium (> 4500 IU but < 175 IU/kilogram, kg, of body weight tinzaparin or > 5000 IU but < 200 IU/kg of body weight dalteparin), and high dose (\u2265 175 IU/kg of body weight tinzaparin or \u2265 200 IU/kg of body weight dalteparin). Thromboprophylaxis dosage was based on local standardized recommendations, not on degree of critical illness or risk of thrombosis. Cox proportional hazards regression was used to estimate hazard ratios with corresponding 95% confidence intervals of death within 28 days from ICU admission. Multivariable models were adjusted for sex, age, body mass index, Simplified Acute Physiology Score III, invasive respiratory support, and initial dosing strategy of thromboprophylaxis.\r\n\r\nA total of 152 patients were included: 67 received low-, 48 medium-, and 37 high-dose thromboprophylaxis. Baseline characteristics did not differ between groups. For patients who received high-dose prophylaxis, mortality was lower (13.5%) compared to those who received medium dose (25.0%) or low dose (38.8%), p = 0.02. The hazard ratio of death was 0.33 (95% confidence intervals 0.13-0.87) among those who received high dose, and 0.88 (95% confidence intervals 0.43-1.83) among those who received medium dose, as compared to those who received low-dose thromboprophylaxis. There were fewer thromboembolic events in the high (2.7%) vs medium (18.8%) and low-dose thromboprophylaxis (17.9%) groups, p = 0.04.\r\n\r\nAmong critically ill COVID-19 patients with respiratory failure, high-dose thromboprophylaxis was associated with a lower risk of death and a lower cumulative incidence of thromboembolic events compared with lower doses.\r\n\r\nClinicaltrials.gov NCT04412304 June 2, 2020, retrospectively registered.", "doi": "10.1186/s13054-020-03375-7", "pmid": "33225952", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-020-03375-7"}, {"db": "pmc", "key": "PMC7680989"}, {"db": "ClinicalTrials.gov", "key": "NCT04412304"}, {"db": "NA", "key": "Available on request due to privacy restrictions", "description": null}], "notes": [], "created": "2020-11-27T10:54:43.450Z", "modified": "2021-02-26T08:45:48.116Z"}, {"entity": "publication", "iuid": "27ca9b35839c4183a6c84f3ec717d99b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27ca9b35839c4183a6c84f3ec717d99b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27ca9b35839c4183a6c84f3ec717d99b"}}, "title": "Erratum to: COVID-19 healthcare demand and mortality in Sweden in response to non-pharmaceutical mitigation and suppression scenarios.", "authors": [{"family": "Sj\u00f6din", "given": "Henrik", "initials": "H"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}, {"family": "Br\u00e4nnstr\u00f6m", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Farooq", "given": "Zia", "initials": "Z"}, {"family": "Kriit", "given": "Hedi Katre", "initials": "HK"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "\u00c5str\u00f6m", "given": "Christofer", "initials": "C"}, {"family": "Thunberg", "given": "Johan", "initials": "J"}, {"family": "S\u00f6derquist", "given": "M\u00e5rten", "initials": "M"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}], "type": "journal article", "published": "2020-11-22", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "volume": null, "issue": null, "issn-l": "0300-5771"}, "abstract": null, "doi": "10.1093/ije/dyaa234", "pmid": "33221845", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5998420"}], "notes": [], "created": "2020-11-27T10:31:07.914Z", "modified": "2020-11-27T10:31:07.934Z"}, {"entity": "publication", "iuid": "2daf9c0238394a92be440a72221722f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2daf9c0238394a92be440a72221722f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2daf9c0238394a92be440a72221722f8"}}, "title": "Association between Renin-Angiotensin-Aldosterone system inhibitor use and COVID-19 Hospitalization and death: A 1,4 million patient Nation-Wide registry analysis.", "authors": [{"family": "Savarese", "given": "Gianluigi", "initials": "G"}, {"family": "Benson", "given": "Lina", "initials": "L"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Lund", "given": "Lars H", "initials": "LH"}], "type": "journal article", "published": "2020-11-22", "journal": {"title": "Eur J Heart Fail", "issn": "1879-0844", "issn-l": "1388-9842", "volume": null, "issue": null, "pages": null}, "abstract": "Renin-angiotensin-aldosterone-system inhibitors (RAASi) improve outcomes in cardiorenal disease but concerns have been raised over increased risk of incident and death from Covid-19. We investigated the association between use of angiotensin converting enzyme inhibitors (ACEi), angiotensin receptor blockers (ARB) or mineralocorticoid receptor antagonists (MRA) and Covid-19 hospitalization/death in a large nationwide population.\r\n\r\nPatients with hypertension, heart failure, diabetes, kidney disease, or ischemic heart disease registered in the Swedish National Patient Registry until February 1 st 2020 were included and followed until May 31st 2020. Covid-19 cases were defined based on hospitalization/death for Covid-19. Multivariable logistic and Cox regressions were fitted to investigate the association between ACEi/ARB and MRA and risk of hospitalization/death for Covid-19 in the overall population, and of all-cause mortality in Covid-19 cases. We performed consistency analysis to quantify the impact of potential unmeasured confounding. Of 1,387,746 patients (60% receiving ACEi/ARB and 5.8% MRA) 7,146 (0.51%) had incident hospitalization/death from Covid-19. After adjustment for 45 variables, ACEi/ARB use was associated with a reduced risk of hospitalization/death for Covid-19 (Odds Ratio [95% Confidence Interval]: 0.86[0.81-0.91]) in the overall population, and with reduced mortality in Covid-19 cases (Hazard Ratio: 0.89[0.82-0.96]). MRA use was not associated with risk of any outcome. Consistency analysis showed that unmeasured confounding would need to be large for there to be harmful signals associated with RAASi use.\r\n\r\nIn a 1.4 million nation-wide cohort, use of RAASi was not associated with increased risk of hospitalization for or death from Covid-19.", "doi": "10.1002/ejhf.2060", "pmid": "33222412", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Public Health": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [], "notes": [], "created": "2020-11-26T14:25:37.655Z", "modified": "2021-04-28T17:56:44.773Z"}, {"entity": "publication", "iuid": "8546463631214e17b48ae9f1fd895681", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8546463631214e17b48ae9f1fd895681.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8546463631214e17b48ae9f1fd895681"}}, "title": "Type I interferons promote germinal centers through B cell intrinsic signaling and dendritic cell dependent Th1 and Tfh cell lineages", "authors": [{"family": "Dahlgren", "given": "Madelene W", "initials": "MW"}, {"family": "Plumb", "given": "Adam W", "initials": "AW"}, {"family": "Niss", "given": "Kristoffer", "initials": "K"}, {"family": "Lahl", "given": "Katharina", "initials": "K"}, {"family": "Brunak", "given": "S\u00f8ren", "initials": "S"}, {"family": "Johansson-Lindbom", "given": "Bengt", "initials": "B"}], "type": "posted-content", "published": "2020-11-21", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.11.20.390625", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-01-15T16:17:24.701Z", "modified": "2021-07-14T07:52:57.666Z"}, {"entity": "publication", "iuid": "3a3a0fa4e51e4effa15fcd47a46ae482", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a3a0fa4e51e4effa15fcd47a46ae482.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a3a0fa4e51e4effa15fcd47a46ae482"}}, "title": "Modelling the test, trace and quarantine strategy to control the COVID-19 epidemic in the state of S\u00e3o Paulo, Brazil.", "authors": [{"family": "Amaku", "given": "Marcos", "initials": "M"}, {"family": "Covas", "given": "Dimas Tadeu", "initials": "DT"}, {"family": "Bezerra Coutinho", "given": "Francisco Antonio", "initials": "FA"}, {"family": "Azevedo Neto", "given": "Raymundo Soares", "initials": "RS"}, {"family": "Struchiner", "given": "Claudio", "initials": "C"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Massad", "given": "Eduardo", "initials": "E"}], "type": "journal article", "published": "2020-11-20", "journal": {"title": "Infect Dis Model", "issn": "2468-0427", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Testing for detecting the infection by SARS-CoV-2 is the bridge between the lockdown and the opening of society. In this paper we modelled and simulated a test-trace-and-quarantine strategy to control the COVID-19 outbreak in the State of S\u00e3o Paulo, Brasil. The State of S\u00e3o Paulo failed to adopt an effective social distancing strategy, reaching at most 59% in late March and started to relax the measures in late June, dropping to 41% in 08 August. Therefore, S\u00e3o Paulo relies heavily on a massive testing strategy in the attempt to control the epidemic. Two alternative strategies combined with economic evaluations were simulated. One strategy included indiscriminately testing the entire population of the State, reaching more than 40 million people at a maximum cost of 2.25 billion USD, that would reduce the total number of cases by the end of 2020 by 90%. The second strategy investigated testing only symptomatic cases and their immediate contacts - this strategy reached a maximum cost of 150 million USD but also reduced the number of cases by 90%. The conclusion is that if the State of S\u00e3o Paulo had decided to adopt the simulated strategy on April the 1st, it would have been possible to reduce the total number of cases by 90% at a cost of 2.25 billion US dollars for the indiscriminate strategy but at a much smaller cost of 125 million US dollars for the selective testing of symptomatic cases and their contacts.", "doi": "10.1016/j.idm.2020.11.004", "pmid": "33235942", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S2468-0427(20)30074-9"}, {"db": "pmc", "key": "PMC7677040"}], "notes": [], "created": "2020-11-27T10:28:12.415Z", "modified": "2022-11-09T08:16:52.712Z"}, {"entity": "publication", "iuid": "5dccf7ce244346c0924ee31e6852684c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5dccf7ce244346c0924ee31e6852684c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5dccf7ce244346c0924ee31e6852684c"}}, "title": "Effect of COVID-19 on maternal and neonatal services - Authors' reply.", "authors": [{"family": "Kc", "given": "Ashish", "initials": "A"}, {"family": "Kinney", "given": "Mary V", "initials": "MV"}, {"family": "Lawn", "given": "Joy E", "initials": "JE"}], "type": "letter", "published": "2020-11-20", "journal": {"title": "Lancet Glob Health", "issn": "2214-109X", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/S2214-109X(20)30486-1", "pmid": "33227257", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2214-109X(20)30486-1"}], "notes": [], "created": "2020-11-27T10:29:07.591Z", "modified": "2020-11-27T10:29:07.611Z"}, {"entity": "publication", "iuid": "20fd08edee8f451198a5e24ea3f85ab0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/20fd08edee8f451198a5e24ea3f85ab0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/20fd08edee8f451198a5e24ea3f85ab0"}}, "title": "Economic arguments in migrant health policymaking: proposing a research agenda.", "authors": [{"family": "Gottlieb", "given": "Nora", "initials": "N"}, {"family": "Trummer", "given": "Ursula", "initials": "U"}, {"family": "Davidovitch", "given": "Nadav", "initials": "N"}, {"family": "Krasnik", "given": "Allan", "initials": "A"}, {"family": "Ju\u00e1rez", "given": "Sol P", "initials": "SP"}, {"family": "Rostila", "given": "Mikael", "initials": "M"}, {"family": "Biddle", "given": "Louise", "initials": "L"}, {"family": "Bozorgmehr", "given": "Kayvan", "initials": "K"}], "type": "letter", "published": "2020-11-20", "journal": {"title": "Global Health", "issn": "1744-8603", "volume": "16", "issue": "1", "pages": "113", "issn-l": "1744-8603"}, "abstract": "Welfare states around the world restrict access to public healthcare for some migrant groups. Formal restrictions on migrants' healthcare access are often justified with economic arguments; for example, as a means to prevent excess costs and safeguard scarce resources. However, existing studies on the economics of migrant health policies suggest that restrictive policies increase rather than decrease costs. This evidence has largely been ignored in migration debates. Amplifying the relationship between welfare state transformations and the production of inequalities, the Covid-19 pandemic may fuel exclusionary rhetoric and politics; or it may serve as an impetus to reconsider the costs that one group's exclusion from health can entail for all members of society.The public health community has a responsibility to promote evidence-informed health policies that are ethically and economically sound, and to counter anti-migrant and racial discrimination (whether overt or masked with economic reasoning). Toward this end, we propose a research agenda which includes 1) the generation of a comprehensive body of evidence on economic aspects of migrant health policies, 2) the clarification of the role of economic arguments in migration debates, 3) (self-)critical reflection on the ethics and politics of the production of economic evidence, 4) the introduction of evidence into migrant health policymaking processes, and 5) the endorsement of inter- and transdisciplinary approaches. With the Covid-19 pandemic and surrounding events rendering the suggested research agenda more topical than ever, we invite individuals and groups to join forces toward a (self-)critical examination of economic arguments in migration and health, and in public health generally.", "doi": "10.1186/s12992-020-00642-8", "pmid": "33218359", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12992-020-00642-8"}, {"db": "pmc", "key": "PMC7677743"}], "notes": [], "created": "2020-11-26T14:30:47.278Z", "modified": "2020-11-27T10:31:53.618Z"}, {"entity": "publication", "iuid": "b738ecb0902748d2b2458b462fd883cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b738ecb0902748d2b2458b462fd883cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b738ecb0902748d2b2458b462fd883cc"}}, "title": "The COVID-19 pandemic and global environmental change: Emerging research needs.", "authors": [{"family": "Barouki", "given": "Robert", "initials": "R"}, {"family": "Kogevinas", "given": "Manolis", "initials": "M"}, {"family": "Audouze", "given": "Karine", "initials": "K"}, {"family": "Belesova", "given": "Kristine", "initials": "K"}, {"family": "Bergman", "given": "Ake", "initials": "A"}, {"family": "Birnbaum", "given": "Linda", "initials": "L"}, {"family": "Boekhold", "given": "Sandra", "initials": "S"}, {"family": "Denys", "given": "Sebastien", "initials": "S"}, {"family": "Desseille", "given": "Celine", "initials": "C"}, {"family": "Drakvik", "given": "Elina", "initials": "E"}, {"family": "Frumkin", "given": "Howard", "initials": "H"}, {"family": "Garric", "given": "Jeanne", "initials": "J"}, {"family": "Destoumieux-Garzon", "given": "Delphine", "initials": "D"}, {"family": "Haines", "given": "Andrew", "initials": "A"}, {"family": "Huss", "given": "Anke", "initials": "A"}, {"family": "Jensen", "given": "Genon", "initials": "G"}, {"family": "Karakitsios", "given": "Spyros", "initials": "S"}, {"family": "Klanova", "given": "Jana", "initials": "J"}, {"family": "Koskela", "given": "Iida-Maria", "initials": "IM"}, {"family": "Laden", "given": "Francine", "initials": "F"}, {"family": "Marano", "given": "Francelyne", "initials": "F"}, {"family": "Franziska Matthies-Wiesler", "given": "Eva", "initials": "E"}, {"family": "Morris", "given": "George", "initials": "G"}, {"family": "Nowacki", "given": "Julia", "initials": "J"}, {"family": "Paloniemi", "given": "Riikka", "initials": "R"}, {"family": "Pearce", "given": "Neil", "initials": "N"}, {"family": "Peters", "given": "Annette", "initials": "A"}, {"family": "Rekola", "given": "Aino", "initials": "A"}, {"family": "Sarigiannis", "given": "Denis", "initials": "D"}, {"family": "\u0160ebkov\u00e1", "given": "Katerina", "initials": "K"}, {"family": "Slama", "given": "Remy", "initials": "R"}, {"family": "Staatsen", "given": "Brigit", "initials": "B"}, {"family": "Tonne", "given": "Cathryn", "initials": "C"}, {"family": "Vermeulen", "given": "Roel", "initials": "R"}, {"family": "Vineis", "given": "Paolo", "initials": "P"}, {"family": "HERA-COVID-19 working group. Electronic address: https://www.heraresearcheu.eu/", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-19", "journal": {"title": "Environ Int", "issn": "1873-6750", "volume": "146", "issue": null, "pages": "106272", "issn-l": "0160-4120"}, "abstract": "The outbreak of COVID-19 raised numerous questions on the interactions between the occurrence of new infections, the environment, climate and health. The European Union requested the H2020 HERA project which aims at setting priorities in research on environment, climate and health, to identify relevant research needs regarding Covid-19. The emergence and spread of SARS-CoV-2 appears to be related to urbanization, habitat destruction, live animal trade, intensive livestock farming and global travel. The contribution of climate and air pollution requires additional studies. Importantly, the severity of COVID-19 depends on the interactions between the viral infection, ageing and chronic diseases such as metabolic, respiratory and cardiovascular diseases and obesity which are themselves influenced by environmental stressors. The mechanisms of these interactions deserve additional scrutiny. Both the pandemic and the social response to the disease have elicited an array of behavioural and societal changes that may remain long after the pandemic and that may have long term health effects including on mental health. Recovery plans are currently being discussed or implemented and the environmental and health impacts of those plans are not clearly foreseen. Clearly, COVID-19 will have a long-lasting impact on the environmental health field and will open new research perspectives and policy needs.", "doi": "10.1016/j.envint.2020.106272", "pmid": "33238229", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0160-4120(20)32227-3"}, {"db": "pmc", "key": "PMC7674147"}], "notes": [], "created": "2020-11-27T10:27:55.912Z", "modified": "2020-11-30T07:44:55.359Z"}, {"entity": "publication", "iuid": "427a5f1f5bfb4a65a0ee29d88d1e1242", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/427a5f1f5bfb4a65a0ee29d88d1e1242.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/427a5f1f5bfb4a65a0ee29d88d1e1242"}}, "title": "Synthesis of Recommendations From 25 Countries and 31 Oncology Societies: How to Navigate Through Covid-19 Labyrinth.", "authors": [{"family": "Kamposioras", "given": "Konstantinos", "initials": "K"}, {"family": "Mauri", "given": "Davide", "initials": "D"}, {"family": "Papadimitriou", "given": "Konstantinos", "initials": "K"}, {"family": "Anthoney", "given": "Alan", "initials": "A"}, {"family": "Hindi", "given": "Nadia", "initials": "N"}, {"family": "Petricevic", "given": "Branka", "initials": "B"}, {"family": "Dambrosio", "given": "Mario", "initials": "M"}, {"family": "Valachis", "given": "Antonis", "initials": "A"}, {"family": "Kountourakis", "given": "Pantelis", "initials": "P"}, {"family": "Kopecky", "given": "Jindrich", "initials": "J"}, {"family": "Kuhar", "given": "Cvetka Gra\u0161i\u010d", "initials": "CG"}, {"family": "Popovic", "given": "Lazar", "initials": "L"}, {"family": "Chilingirova", "given": "Nataliya P", "initials": "NP"}, {"family": "Zarkavelis", "given": "George", "initials": "G"}, {"family": "de Mello", "given": "Ramon Andrade", "initials": "RA"}, {"family": "Plaveti\u0107", "given": "Natalija Dedi\u0107", "initials": "ND"}, {"family": "Christopoulos", "given": "Christos", "initials": "C"}, {"family": "Mostert", "given": "Bianca", "initials": "B"}, {"family": "Goffin", "given": "John R", "initials": "JR"}, {"family": "Tzachanis", "given": "Dimitiros", "initials": "D"}, {"family": "Saraireh", "given": "Haytham Hamed", "initials": "HH"}, {"family": "Ma", "given": "Fei", "initials": "F"}, {"family": "Pavese", "given": "Ida", "initials": "I"}, {"family": "Tolia", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2020-11-19", "journal": {"title": "Front Oncol", "issn": "2234-943X", "volume": "10", "issue": null, "pages": "575148", "issn-l": null}, "abstract": "Pandemic COVID-19 is an unexpected challenge for the oncological community, indicating potential detrimental effects on cancer patients. Our aim was to summarize the converging key points providing a general guidance in order to support decision making, pertaining to the oncologic care in the middle of a global outbreak.\n\nWe did an international online search in twenty five countries that have managed a surge in cancer patient numbers. We collected the recommendations from thirty one medical oncology societies.\n\nBy synthesizing guidelines for a) oncology service delivery adjustments, b) general and specific treatment adaptations, and c) discrepancies from guidelines comparison, we present a clinical synopsis with the forty more crucial statements. A Covid-19 risk stratification base was also created in order to obtain a quick, objective patient assessment and a risk-benefit evaluation on a case-by-case basis.\n\nIn an attempt to face these complex needs and due to limited understanding of COVID-19, a variability of recommendations based on general epidemiological and infectious disease principles rather than definite cancer-related evidence has evolved. Additionally, the absence of an effective treatment or vaccine requires the development of cancer management guidance, capitalizing on comprehensive COVID-19 oncology experience globally.", "doi": "10.3389/fonc.2020.575148", "pmid": "33330049", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7711151"}], "notes": [], "created": "2020-12-21T09:02:31.979Z", "modified": "2021-01-10T18:12:27.920Z"}, {"entity": "publication", "iuid": "edb87ec1c2214788a11083c24eca19c3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/edb87ec1c2214788a11083c24eca19c3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/edb87ec1c2214788a11083c24eca19c3"}}, "title": "Sleep Laboratories Reopening and COVID-19: A European Perspective.", "authors": [{"family": "Schiza", "given": "Sophia", "initials": "S"}, {"family": "Simonds", "given": "Anita", "initials": "A"}, {"family": "Randerath", "given": "Winfried", "initials": "W"}, {"family": "Fanfulla", "given": "Francesco", "initials": "F"}, {"family": "Testelmans", "given": "Dries", "initials": "D"}, {"family": "Grote", "given": "Ludger", "initials": "L"}, {"family": "Montserrat", "given": "Joseph M", "initials": "JM"}, {"family": "Pepin", "given": "Jean-Louis", "initials": "JL"}, {"family": "Verbracken", "given": "Johan", "initials": "J"}, {"family": "Ersu", "given": "Refika", "initials": "R"}, {"family": "Bonsignore", "given": "Maria R", "initials": "MR"}], "type": "journal article", "published": "2020-11-19", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "volume": null, "issue": null, "issn-l": "0903-1936"}, "abstract": "The clinical activities regarding sleep disordered breathing (SDB) have been sharply interrupted during the initial phase of the COVID-19 epidemic throughout Europe. In the last months, activities have gradually restarted, according to epidemiological phase of COVID-19 and National recommendations. The recent increase in cases throughout Europe obliges to reconsider management strategies of SDB accordingly. Diagnosis of SDB and initiation of treatment pose some specific problems to be addressed to preserve safety of the patients and health personnel. This perspective document by a group of European sleep experts aims at summarising some different approaches followed in Europe and United States, which reflect National recommendations according to the epidemiological phase of the COVID-19 infection. Respiratory sleep medicine will likely change in the near future, and use of telemedicine will grow to avoid unnecessary risks and continue to provide optimal care to the patients. The document also covers pediatric sleep studies and indications for titration of noninvasive ventilation, as well as precautions to be followed by patients who are already on positive airway pressure treatment. A single consensus document developed by the European Respiratory Society and National Societies would be desirable to harmonise SDB management throughout Europe.", "doi": "10.1183/13993003.02722-2020", "pmid": "33214202", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "13993003.02722-2020"}, {"db": "pmc", "key": "PMC7683791"}], "notes": [], "created": "2020-11-27T10:43:18.484Z", "modified": "2020-11-27T10:43:18.495Z"}, {"entity": "publication", "iuid": "f3b6d71139b14f2a8521373afff4ffaa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f3b6d71139b14f2a8521373afff4ffaa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f3b6d71139b14f2a8521373afff4ffaa"}}, "title": "Genetically proxied interleukin-6 receptor inhibition: opposing associations with COVID-19 and pneumonia.", "authors": [{"family": "Larsson", "given": "Susanna C", "initials": "SC"}, {"family": "Burgess", "given": "Stephen", "initials": "S"}, {"family": "Gill", "given": "Dipender", "initials": "D"}], "type": "letter", "published": "2020-11-19", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "issn-l": "0903-1936", "volume": "57", "issue": "1", "pages": null}, "abstract": null, "doi": "10.1183/13993003.03545-2020", "pmid": "33214204", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "13993003.03545-2020"}, {"db": "pmc", "key": "PMC7683792"}], "notes": [], "created": "2020-11-26T14:34:25.701Z", "modified": "2021-02-26T08:45:14.513Z"}, {"entity": "publication", "iuid": "1a27e0a50b4d4dfeb5ab4e7e90004286", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1a27e0a50b4d4dfeb5ab4e7e90004286.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1a27e0a50b4d4dfeb5ab4e7e90004286"}}, "title": "Brief Online Cognitive Behavioural Intervention for Dysfunctional Worry Related to the COVID-19 Pandemic: A Randomised Controlled Trial.", "authors": [{"family": "Wahlund", "given": "Tove", "initials": "T"}, {"family": "Mataix-Cols", "given": "David", "initials": "D"}, {"family": "Olofsdotter Lauri", "given": "Klara", "initials": "K"}, {"family": "de Schipper", "given": "Elles", "initials": "E"}, {"family": "Lj\u00f3tsson", "given": "Brj\u00e1nn", "initials": "B"}, {"family": "Aspvall", "given": "Kristina", "initials": "K"}, {"family": "Andersson", "given": "Erik", "initials": "E"}], "type": "journal article", "published": "2020-11-19", "journal": {"title": "Psychother Psychosom", "issn": "1423-0348", "issn-l": "0033-3190", "volume": null, "issue": null, "pages": "1-9"}, "abstract": "Worries about the immediate and long-term consequences of the COVID-19 pandemic may for some individuals develop into pervasive worry that is disproportionate in its intensity or duration and significantly interferes with everyday life.\r\n\r\nThe aim of this study was to investigate if a brief self-guided, online psychological intervention can reduce the degree of dysfunctional worry related to the COVID-19 pandemic and associated symptoms.\r\n\r\n670 adults from the Swedish general population reporting daily uncontrollable worry about CO-VID-19 and its possible consequences (e.g., illness, death, the economy, one's family) were randomised (1:1 ratio) to a 3-week self-guided, online cognitive behavioural intervention targeting dysfunctional COVID-19 worry and associated symptoms, or a waiting list of equal duration. The primary outcome measure was a COVID-19 adapted version of the Generalised Anxiety Disorder 7-item scale administered at baseline and weeks 1-3 (primary endpoint). Follow-up assessments were conducted 1 month after treatment completion. The trial was registered on ClinicalTrials.gov (NCT04341922) before inclusion of the first participant.\r\n\r\nThe main pre-specified intention-to-treat analysis indicated significant reductions in COVID-19-related worry for the intervention group compared to the waiting list (\u03b2 = 1.14, Z = 9.27, p < 0.001), corresponding to a medium effect size (bootstrapped d = 0.74 [95% CI: 0.58-0.90]). Improvements were also seen on all secondary measures, including mood, daily functioning, insomnia, and intolerance of uncertainty. Participant satisfaction was high. No serious adverse events were recorded.\r\n\r\nA brief digital and easily scalable self-guided psychological intervention can significantly reduce dysfunctional worry and associated behavioural symptoms related to the COVID-19 pandemic.", "doi": "10.1159/000512843", "pmid": "33212440", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "000512843"}, {"db": "ClinicalTrials.gov", "key": "NCT04341922"}], "notes": [], "created": "2020-11-27T09:45:47.728Z", "modified": "2021-02-26T08:46:59.845Z"}, {"entity": "publication", "iuid": "8da9a0a08cdf424ab35a2b5c1c3da037", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8da9a0a08cdf424ab35a2b5c1c3da037.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8da9a0a08cdf424ab35a2b5c1c3da037"}}, "title": "The known unknowns of T cell immunity to COVID-19.", "authors": [{"family": "Karlsson", "given": "Annika C", "initials": "AC", "orcid": "0000-0002-2028-8393", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9abf28110888427497db1e4abf6ff71d.json"}}, {"family": "Humbert", "given": "Marion", "initials": "M", "orcid": "0000-0002-1710-1479", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e43ab29ae76344aa83909afff892c6db.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}], "type": "journal article", "published": "2020-11-18", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "issn-l": "2470-9468", "volume": "5", "issue": "53", "pages": null}, "abstract": "Tremendous progress has been made in understanding the role of T cell immunity in acute and convalescent COVID-19 infection. Here we shed light on the \"known unknowns\" of pre-existing and acquired T cell responses in relation to acute and convalescent SARS-CoV-2 infection.", "doi": "10.1126/sciimmunol.abe8063", "pmid": "33208380", "labels": {"Type: Review": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "5/53/eabe8063"}], "notes": [], "created": "2020-11-27T09:49:11.516Z", "modified": "2023-06-19T14:56:20.106Z"}, {"entity": "publication", "iuid": "ab717979c71e46bbb7a827972b7a2835", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ab717979c71e46bbb7a827972b7a2835.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ab717979c71e46bbb7a827972b7a2835"}}, "title": "The impact of early public health interventions on SARS-CoV-2 transmission and evolution", "authors": [{"family": "Duchene", "given": "Sebastian", "initials": "S"}, {"family": "Featherstone", "given": "Leo", "initials": "L"}, {"family": "de Blasio", "given": "Birgitte Freiesleben", "initials": "BF"}, {"family": "Holmes", "given": "Edward C", "initials": "EC"}, {"family": "Bohlin", "given": "Jon", "initials": "J"}, {"family": "Pettersson", "given": "John H O", "initials": "JHO"}], "type": "posted-content", "published": "2020-11-18", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Many countries have attempted to control COVID-19 through the implementation of non-pharmaceutical interventions. However, it remains unclear how different control strategies have impacted SARS-CoV-2 virus transmission dynamics at the local level. Using complete SARS-CoV-2 genomes, we inferred the relative frequencies of virus importation and exportation, as well as virus transmission chain dynamics in Nordic countries - Denmark, Finland, Iceland, Norway and Sweden - during the first months of the pandemic. Our analyses revealed that Sweden experienced more numerous transmission chains, which tended to have more cases, and were of longer duration, a set of features that increased with time. Together with Denmark, Sweden was also a net exporter of SARS-CoV-2. Hence, Sweden effectively constituted an epidemiological and evolutionary \u2018refugia\u2019 that enabled the virus to maintain active transmission and spread to other geographic localities. This analysis highlights the utility of genomic surveillance where active transmission chain monitoring is a key metric.", "doi": "10.1101/2020.11.18.20233767", "pmid": null, "labels": {"Category: Genomics & transcriptomics": null, "Type: Preprint": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://www.medrxiv.org/content/medrxiv/early/2021/07/06/2020.11.18.20233767/DC1/embed/media-1.zip?download=true", "description": "Data available on GISAID, accession numbers found here (in the Supplementary Material)"}], "notes": [], "created": "2021-06-04T12:15:38.051Z", "modified": "2021-11-18T10:30:26.404Z"}, {"entity": "publication", "iuid": "03bef30654104a3da77bdc8ad1380279", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/03bef30654104a3da77bdc8ad1380279.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/03bef30654104a3da77bdc8ad1380279"}}, "title": "Misinformation, chiropractic, and the COVID-19 pandemic.", "authors": [{"family": "Ax\u00e9n", "given": "Iben", "initials": "I"}, {"family": "Bergstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Bronson", "given": "Marc", "initials": "M"}, {"family": "C\u00f4t\u00e9", "given": "Pierre", "initials": "P"}, {"family": "Nim", "given": "Casper Glissmann", "initials": "CG"}, {"family": "Goncalves", "given": "Guillaume", "initials": "G"}, {"family": "H\u00e9bert", "given": "Jeffrey J", "initials": "JJ"}, {"family": "Hertel", "given": "Joakim Axel", "initials": "JA"}, {"family": "Innes", "given": "Stanley", "initials": "S"}, {"family": "Larsen", "given": "Ole Kristoffer", "initials": "OK"}, {"family": "Meyer", "given": "Anne-Laure", "initials": "AL"}, {"family": "O'Neill", "given": "S\u00f8ren", "initials": "S"}, {"family": "Perle", "given": "Stephen M", "initials": "SM"}, {"family": "Weber", "given": "Kenneth A", "initials": "KA"}, {"family": "Young", "given": "Kenneth J", "initials": "KJ"}, {"family": "Leboeuf-Yde", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2020-11-18", "journal": {"title": "Chiropr Man Therap", "issn": "2045-709X", "volume": "28", "issue": "1", "pages": "65", "issn-l": "2045-709X"}, "abstract": "In March 2020, the World Health Organization elevated the coronavirus disease (COVID-19) epidemic to a pandemic and called for urgent and aggressive action worldwide. Public health experts have communicated clear and emphatic strategies to prevent the spread of COVID-19. Hygiene rules and social distancing practices have been implemented by entire populations, including 'stay-at-home' orders in many countries. The long-term health and economic consequences of the COVID-19 pandemic are not yet known.\n\nDuring this time of crisis, some chiropractors made claims on social media that chiropractic treatment can prevent or impact COVID-19. The rationale for these claims is that spinal manipulation can impact the nervous system and thus improve immunity. These beliefs often stem from nineteenth-century chiropractic concepts. We are aware of no clinically relevant scientific evidence to support such statements. We explored the internet and social media to collect examples of misinformation from Europe, North America, Australia and New Zealand regarding the impact of chiropractic treatment on immune function. We discuss the potential harm resulting from these claims and explore the role of chiropractors, teaching institutions, accrediting agencies, and legislative bodies.\n\nMembers of the chiropractic profession share a collective responsibility to act in the best interests of patients and public health. We hope that all chiropractic stakeholders will view the COVID-19 pandemic as a call to action to eliminate the unethical and potentially dangerous claims made by chiropractors who practise outside the boundaries of scientific evidence.", "doi": "10.1186/s12998-020-00353-2", "pmid": "33208144", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12998-020-00353-2"}, {"db": "pmc", "key": "PMC7672412"}], "notes": [], "created": "2020-11-26T12:36:03.161Z", "modified": "2020-11-27T09:51:10.068Z"}, {"entity": "publication", "iuid": "fda32fda6e5f47cd98b64d825f7259cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fda32fda6e5f47cd98b64d825f7259cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fda32fda6e5f47cd98b64d825f7259cb"}}, "title": "CETSA MS Profiling for a Comparative Assessment of FDA-Approved Antivirals Repurposed for COVID-19 Therapy Identifies TRIP13 as a Remdesivir Off-Target.", "authors": [{"family": "Friman", "given": "Tomas", "initials": "T"}, {"family": "Chernobrovkin", "given": "Alexey", "initials": "A"}, {"family": "Martinez Molina", "given": "Daniel", "initials": "D"}, {"family": "Arnold", "given": "Laurence", "initials": "L"}], "type": "journal article", "published": "2020-11-18", "journal": {"title": "SLAS Discov", "issn": "2472-5560", "issn-l": null, "volume": null, "issue": null, "pages": "2472555220973597"}, "abstract": "The reuse of preexisting small molecules for a novel emerging disease threat is a rapid measure to discover unknown applications for previously validated therapies. A pertinent and recent example where such a strategy could be employed is in the fight against coronavirus disease 2019 (COVID-19). Therapies designed or discovered to target viral proteins also have off-target effects on the host proteome when employed in a complex physiological environment. This study aims to assess these host cell targets for a panel of FDA-approved antiviral compounds including remdesivir, using the cellular thermal shift assay (CETSA) coupled with mass spectrometry (CETSA MS) in noninfected cells. CETSA MS is a powerful method to delineate direct and indirect interactions between small molecules and protein targets in intact cells. Biologically active compounds can induce changes in thermal stability, in their primary binding partners, and in proteins that in turn interact with the direct targets. Such engagement of host targets by antiviral drugs may contribute to the clinical effect against the virus but can also constitute a liability. We present here a comparative study of CETSA molecular target engagement fingerprints of antiviral drugs to better understand the link between off-targets and efficacy.", "doi": "10.1177/2472555220973597", "pmid": "33208020", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2020-11-30T16:12:53.941Z", "modified": "2021-02-26T08:45:25.950Z"}, {"entity": "publication", "iuid": "be13b13ee3b04c2288d72970f20ea3a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be13b13ee3b04c2288d72970f20ea3a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be13b13ee3b04c2288d72970f20ea3a2"}}, "title": "The limits of estimating COVID-19 intervention effects using Bayesian models", "authors": [{"family": "Elofsson", "given": "Arne", "initials": "A"}, {"family": "Bryant", "given": "Patrick", "initials": "P"}], "type": "posted-content", "published": "2020-11-17", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To limit the rapid spread of COVID-19, most governments have introduced different non-pharmaceutical interventions, which might have severe costs for society. Therefore, it is crucial to evaluate the most cost-effective interventions, using, for instance, Bayesian modelling. Such modelling efforts have deemed lockdown to account for 81% of the reduction in R0, contributing to government policies. Here, we show that these conclusions are unsupported and that policies therefore should not be based on these studies.", "doi": "10.1101/2020.08.14.20175240", "pmid": null, "labels": {"Funder: VR": null, "Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-17T13:25:54.970Z", "modified": "2021-02-26T08:45:48.630Z"}, {"entity": "publication", "iuid": "a9a372ecfb2043dcbeb9484cacd0b451", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a9a372ecfb2043dcbeb9484cacd0b451.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a9a372ecfb2043dcbeb9484cacd0b451"}}, "title": "The effect of opening up the US on COVID-19 spread", "authors": [{"family": "Elofsson", "given": "Arne", "initials": "A"}, {"family": "Bryant", "given": "Patrick", "initials": "P"}], "type": null, "published": "2020-11-17", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "In response to the pandemic development of the novel coronavirus (SARS-CoV-2), governments worldwide have implemented strategies of suppression by non-pharmaceutical interventions (NPIs). Such NPIs include social distancing, school closures, limiting international travel and complete lockdown. Worldwide the NPIs enforced to limit the spread of COVID-19 are now being lifted. Understanding how the risk increases when NPIs are lifted is important for decision making. Treating NPIs equally across countries and regions limits the possibility for modelling differences in epidemic response, as the response to the NPIs influences can vary between regions and this can affect the epidemic outcome, so do the strength and speed of lifting these. Our solution to this is to measure mobility changes from mobile phone data and their impacts on the basic reproductive number. We model the epidemic in all US states to compare the difference in outcome if NPIs are lifted or retained. We show that keeping NPIs just a few weeks longer has a substantial impact on the epidemic outcome.", "doi": "10.1101/2020.07.03.20145649", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "URL", "key": "https://github.com/patrickbryant1/COVID19.github.io/tree/master/simulations/mobility/dev/US", "description": "Analysis code and data"}], "notes": [], "created": "2020-11-17T13:20:52.223Z", "modified": "2022-11-09T08:20:04.453Z"}, {"entity": "publication", "iuid": "7ca4e69b988a427d86f38d90955b2c7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7ca4e69b988a427d86f38d90955b2c7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7ca4e69b988a427d86f38d90955b2c7e"}}, "title": "Perturbations in the mononuclear phagocyte landscape associated with COVID-19 disease severity", "authors": [{"family": "Kvedaraite", "given": "Egle", "initials": "E"}, {"family": "Hertwig", "given": "Laura", "initials": "L"}, {"family": "Indranil", "given": "Sinha", "initials": "S"}, {"family": "Ponzetta", "given": "Andrea", "initials": "A"}, {"family": "Hed Myrberg", "given": "Ida", "initials": "I"}, {"family": "Magdalini Lourda", "given": "M", "initials": "M"}, {"family": "Dzidic", "given": "Majda", "initials": "M"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Klingstrom", "given": "Jonas", "initials": "J"}, {"family": "Folkesson", "given": "Elin", "initials": "E"}, {"family": "Muvva", "given": "Rao", "initials": "R"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Brighenti", "given": "Susanna", "initials": "S"}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A"}, {"family": "Lars I. Eriksson", "given": "Lars I.", "initials": "LI"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Stralin", "given": "Krustoffer", "initials": "K"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Ginhoux", "given": "Florent", "initials": "F"}, {"family": "Bjorkstrom", "given": "Niclas", "initials": "N"}, {"family": "Henter", "given": "Jan-Inge", "initials": "J"}, {"family": "Svensson", "given": "Mattias", "initials": "M"}], "type": "journal article", "published": "2020-11-17", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "issn-l": "0027-8424", "volume": "118", "issue": "6", "pages": null}, "abstract": "Monocytes and dendritic cells are crucial mediators of innate and adaptive immune responses during viral infection, but misdirected responses by these cells might contribute to immunopathology. A comprehensive map of the mononuclear phagocyte (MNP) landscape during SARS-CoV-2 infection and concomitant COVID-19 disease is lacking. We performed 25-color flow cytometry-analysis focusing on MNP lineages in SARS-CoV-2 infected patients with moderate and severe COVID-19. While redistribution of monocytes towards intermediate subset and decrease in circulating DCs occurred in response to infection, severe disease associated with appearance of Mo-MDSC-like cells and a higher frequency of pre-DC2. Furthermore, phenotypic alterations in MNPs, and their late precursors, were cell-lineage specific and in select cases associated with severe disease. Finally, unsupervised analysis revealed that the MNP profile, alone, could identify a cluster of COVID-19 non-survivors. This study provides a reference for the MNP response to clinical SARS-CoV-2 infection and unravel myeloid dysregulation associated with severe COVID-19.", "doi": "10.1073/pnas.2018587118", "pmid": "33479167", "labels": {"Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null, "Funder: Vinnova": null, "Funder: VR": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-17T17:34:32.059Z", "modified": "2021-06-13T14:15:44.123Z"}, {"entity": "publication", "iuid": "19520c0d2e594922b47369a93ce61cb0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19520c0d2e594922b47369a93ce61cb0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19520c0d2e594922b47369a93ce61cb0"}}, "title": "Outcome prediction by serum calprotectin in patients with COVID-19 in the emergency department.", "authors": [{"family": "Bauer", "given": "Wolfgang", "initials": "W"}, {"family": "Diehl-Wiesenecker", "given": "Eva", "initials": "E"}, {"family": "Ulke", "given": "Jannis", "initials": "J"}, {"family": "Galtung", "given": "Noa", "initials": "N"}, {"family": "Havelka", "given": "Aleksandra", "initials": "A"}, {"family": "Hegel", "given": "J Kolja", "initials": "JK"}, {"family": "Tauber", "given": "Rudolf", "initials": "R"}, {"family": "Somasundaram", "given": "Rajan", "initials": "R"}, {"family": "Kappert", "given": "Kai", "initials": "K"}], "type": "letter", "published": "2020-11-17", "journal": {"title": "J Infect", "issn": "1532-2742", "volume": null, "issue": null, "issn-l": "0163-4453"}, "abstract": null, "doi": "10.1016/j.jinf.2020.11.016", "pmid": "33217473", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S0163-4453(20)30711-8"}, {"db": "pmc", "key": "PMC7670934"}], "notes": [], "created": "2020-11-26T14:31:48.547Z", "modified": "2021-02-26T08:45:02.871Z"}, {"entity": "publication", "iuid": "9ca4b2c8bb234e6aaec0b39b03ce25c2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ca4b2c8bb234e6aaec0b39b03ce25c2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ca4b2c8bb234e6aaec0b39b03ce25c2"}}, "title": "Outcome of COVID-19 in multiple myeloma patients in relation to treatment.", "authors": [{"family": "Susek", "given": "K. H.,", "initials": "KH"}, {"family": "Gran", "given": "C.,", "initials": "C"}, {"family": "Ljunggren", "given": "H. G.,", "initials": "HG"}, {"family": "Alici", "given": "E.,", "initials": "E"}, {"family": "Nahi", "given": "H.", "initials": "H"}], "type": null, "published": "2020-11-17", "journal": {"title": "Eur J Haematol.", "issn": null, "issn-l": null, "volume": "105", "issue": "6", "pages": "751-754"}, "abstract": "COVID\u201019 has emerged as a global pandemic. Cancer patients have been reported to be at higher risk for adverse outcome of COVID\u201019. Studies are ongoing to decipher the risk factors and risk groups among cancer patients as well as strategies to refine treatment approaches. Here, we report eight patients with multiple myeloma that underwent immunomodulatory therapies with daratumumab or lenalidomide\u2010based combination treatments and one patient with smoldering multiple myeloma, all of which presented with symptomatic COVID\u201019. We report that patients that succumbed to COVID\u201019 presented with either progressive tumor disease under daratumumab treatment or were in remission under lenalidomide\u2010dexamethasone treatment.", "doi": "10.1111/ejh.13502", "pmid": null, "labels": {"Type: Journal article": null, "Funder: Vinnova": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Provided in the article: Characteristics, treatments, COVID-19-related outcomes, additional laboratory and clinical data for 9 patients", "description": null}], "notes": [], "created": "2020-11-04T16:20:40.991Z", "modified": "2021-02-26T08:45:48.516Z"}, {"entity": "publication", "iuid": "5c098e68a7284bf4bc17ae331fd69552", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c098e68a7284bf4bc17ae331fd69552.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c098e68a7284bf4bc17ae331fd69552"}}, "title": "Modelling the dispersion of SARS-CoV-2 on a dynamic network graph", "authors": [{"family": "Elofsson", "given": "Arne", "initials": "A"}, {"family": "Bryant", "given": "Patrick", "initials": "P"}], "type": null, "published": "2020-11-17", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Background When modelling the dispersion of an epidemic using R0, one only considers the average number of individuals each infected individual will infect. However, we know from extensive studies of social networks that there is significant variation in the number of connections and thus social contacts each individual has. Individuals with more social contacts are more likely to attract and spread infection. These individuals are likely the drivers of the epidemic, so-called superspreaders. When many superspreaders are immune, it becomes more difficult for the disease to spread, as the connectedness of the social network dramatically decreases. If one assumes all individuals being equally connected and thus as likely to spread disease as in a SIR model, this is not true.\r\n\r\nMethods To account for the impact of social network structure on epidemic development, we model the dispersion of SARS-CoV-2 on a dynamic preferential attachment graph which changes appearance proportional to observed mobility changes. We sample a serial interval distribution that determines the probability of dispersion for all infected nodes each day. We model the dispersion in different age groups using age-specific infection fatality rates. We vary the infection probabilities in different age groups and analyse the outcome.\r\n\r\nResults The impact of movement on network dynamics plays a crucial role in the spread of infections. We find that higher movement results in higher spread due to an increased probability of new connections being made within a social network. We show that saturation in the dispersion can be reached much earlier on a preferential attachment graph compared to spread on a random graph, which is more similar to estimations using R0.\r\n\r\nConclusions We provide a novel method for modelling epidemics by using a dynamic network structure related to observed mobility changes. The social network structure plays a crucial role in epidemic development, something that is often overlooked.", "doi": "10.1101/2020.10.19.20215046", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Genomics & transcriptomics": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "URL", "key": "https://github.com/patrickbryant1/epidemic_net", "description": "Code, data, and results related to modelling the spread of COVID-19 on a dynamic social network with spread reduction according to Google mobility changes"}], "notes": [], "created": "2020-11-17T13:24:02.281Z", "modified": "2022-11-09T08:21:07.257Z"}, {"entity": "publication", "iuid": "bb13de8cbe1a40c4890b291266d4ec34", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb13de8cbe1a40c4890b291266d4ec34.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb13de8cbe1a40c4890b291266d4ec34"}}, "title": "Global analysis of more than 50,000 SARS-CoV-2 genomes reveals epistasis between eight viral genes", "authors": [{"family": "Zeng", "given": "Hong Li", "initials": "HL"}, {"family": "Dichio", "given": "Vito", "initials": "V"}, {"family": "Rodr\u00edguez Horta", "given": "Edwin", "initials": "E"}, {"family": "Thorell", "given": "Kaisa", "initials": "K"}, {"family": "Aurell", "given": "Erik", "initials": "E"}], "type": "journal-article", "published": "2020-11-17", "journal": {"title": "Proc Natl Acad Sci USA", "issn": "0027-8424", "issn-l": "0027-8424", "volume": null, "issue": null, "pages": "202012331"}, "abstract": null, "doi": "10.1073/pnas.2012331117", "pmid": null, "labels": {"Type: Journal article": null, "Funder: H2020": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "URL", "key": "https://www.pnas.org/content/117/49/31519#sec-14", "description": "Data is included in the article and supplementary information"}], "notes": [], "created": "2020-11-18T10:56:55.452Z", "modified": "2021-11-18T10:22:35.025Z"}, {"entity": "publication", "iuid": "c2f01753f5bb4ec59ebe3c6b8efa29ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2f01753f5bb4ec59ebe3c6b8efa29ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2f01753f5bb4ec59ebe3c6b8efa29ca"}}, "title": "Case report and systematic review suggest that children may experience similar long-term effects to adults after clinical COVID-19.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "journal article", "published": "2020-11-17", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "volume": null, "issue": null, "issn-l": null}, "abstract": "Persistent symptoms in adults after COVID-19 are emerging and the term long COVID is increasingly appearing in the literature. However, paediatric data are scarce .\n\nThis paper contains a case report of five Swedish children and the long-term symptoms reported by their parents. It also includes a systematic literature review of the MEDLINE, EMBASE and Web of Science databases and the medRxiv/bioRxiv preprint servers up to 2 November 2020.\n\nThe five children with potential long covid had a median age of 12 years (range 9-15) and four were girls. They had symptoms for 6-8 months after their clinical diagnoses of COVID-19. None were hospitalised at diagnosis, but one was later admitted for peri-myocarditis. All five children had fatigue, dyspnoea, heart palpitations or chest pain and four had headaches, difficulties concentrating, muscle weakness, dizziness and sore throats. Some had improved after 6-8 months, but they all suffered from fatigue and none had fully returned to school. The systematic review identified 179 publications and 19 of these were deemed relevant and read in detail. None contained any information on long COVID in children.\n\nChildren may experience similar long COVID symptoms to adults and females may be more affected.", "doi": "10.1111/apa.15673", "pmid": "33205450", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Provided in the article: clinical data reported by parents of five children with long-term effects of COVID-19", "description": null}], "notes": [], "created": "2020-11-26T12:26:47.588Z", "modified": "2021-02-26T08:45:48.669Z"}, {"entity": "publication", "iuid": "fb3edae98f5e4ab289309ee5f0d9bba6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb3edae98f5e4ab289309ee5f0d9bba6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb3edae98f5e4ab289309ee5f0d9bba6"}}, "title": "A complicated way of boiling water: nuclear safety in water history.", "authors": [{"family": "Evens", "given": "Siegfried", "initials": "S"}], "type": "journal article", "published": "2020-11-17", "journal": {"title": "Water Hist", "issn": "1877-7236", "volume": null, "issue": null, "pages": "1-14", "issn-l": null}, "abstract": "Water and nuclear reactors are much closer intertwined than usually perceived. First, water is the source of the steam that drives the turbines of most nuclear power plants around the world. Next to generating electricity, water is the key to preventing accidents in nuclear plants. As uranium keeps on generating heat when the power plant is turned off, its core needs to be cooled continuously. This crucial connection between water and nuclear is focus of the paper. Nuclear safety will appear as relying heavily on earlier knowledge, institutions, and regulatory frameworks, which were related to water. The three parts of this article discuss technologies, actors and risks of nuclear power. Studying water as a resource in a much broader sense than being boiled for steam shows how determining water is to make nuclear power function. As this paper is part of a special issue, Water History in the time of COVID-19, it has undergone modified peer review.", "doi": "10.1007/s12685-020-00258-0", "pmid": "33224318", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "258"}, {"db": "pmc", "key": "PMC7671176"}], "notes": [], "created": "2020-11-27T10:30:21.178Z", "modified": "2020-11-27T10:30:21.198Z"}, {"entity": "publication", "iuid": "b4ad408a15f543c599c0cb75863ae60d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b4ad408a15f543c599c0cb75863ae60d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b4ad408a15f543c599c0cb75863ae60d"}}, "title": "Mitigating COVID-19 Impact on the Portuguese Population Mental Health: The Opportunity That Lies in Digital Mental Health.", "authors": [{"family": "Mendes-Santos", "given": "Cristina", "initials": "C"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Weiderpass", "given": "Elisabete", "initials": "E"}, {"family": "Santana", "given": "Rui", "initials": "R"}], "type": "journal article", "published": "2020-11-16", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "553345", "issn-l": "2296-2565"}, "abstract": "COVID-19 mitigation measures present unprecedented challenges in mental healthcare delivery, posing high risk to the mental health of at-risk populations, namely patients diagnosed with COVID-19, frontline healthcare providers, and those submitted to quarantine or isolation measures, as well as the general population. Ensuring safe and equitable access to mental healthcare by these groups entails resorting to innovative psychosocial intervention strategies, such as digital mental health. In this perspective piece, we describe the impact of COVID-19 on the Portuguese population's mental health, present an overview on initiatives developed to address the challenges currently faced by the Portuguese mental healthcare system, and discuss how the timely implementation of a comprehensive digital mental health strategy, coupling research, education, implementation, and quality assessment initiatives, might buffer COVID-19's impact on the Portuguese society.", "doi": "10.3389/fpubh.2020.553345", "pmid": "33313033", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7701327"}], "notes": [], "created": "2020-12-21T10:17:55.193Z", "modified": "2021-02-26T08:47:00.167Z"}, {"entity": "publication", "iuid": "300659f5bed046a18cd1b58ab66f9644", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/300659f5bed046a18cd1b58ab66f9644.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/300659f5bed046a18cd1b58ab66f9644"}}, "title": "International Study of Movement Behaviors in the Early Years (SUNRISE): Results from SUNRISE Sweden's Pilot and COVID-19 Study.", "authors": [{"family": "Delisle Nystr\u00f6m", "given": "Christine", "initials": "C"}, {"family": "Alexandrou", "given": "Christina", "initials": "C"}, {"family": "Henstr\u00f6m", "given": "Maria", "initials": "M"}, {"family": "Nilsson", "given": "Ellinor", "initials": "E"}, {"family": "Okely", "given": "Anthony D", "initials": "AD"}, {"family": "Wehbe El Masri", "given": "Serina", "initials": "S"}, {"family": "L\u00f6f", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2020-11-16", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "22", "pages": null}, "abstract": "The International Study of Movement Behaviors in the Early Years (SUNRISE) was initiated in response to the 2019 WHO guidelines for physical activity, sedentary behavior, and sleep in children aged 0-5 years. This Swedish pilot study aimed to: (i) assess the proportion of preschoolers meeting the guidelines, (ii) evaluate the feasibility of the methods for the SUNRISE study, and (iii) assess how movement behaviors have been affected in preschoolers during the COVID-19 pandemic. Physical activity and sleep (waist-worn ActiGraph); screen time and movement behaviors (parental questionnaire); motor skills (Ages and Stages Questionnaire); and executive functions (3 iPad games) were assessed in 100 Swedish preschoolers ( n = 58 boys). There were 19.4% of preschoolers (n = 14) who met the WHO guidelines. The motor skill and executive function assessments were feasible; however, 20% refused to wear the ActiGraph overnight. Additionally, during the pandemic Swedish children's physical activity, time spent outside on weekdays and weekend days, and screen time significantly increased (+53; +124; +68; +30min/day, respectively, all p-values \u2264 0.001). Methods for the SUNRISE study were feasible in a Swedish context; however, considerations to switch to a wrist-worn accelerometer should be made. Furthermore, children's physical activity increased during the pandemic, which is likely due to how the rules/restrictions were implemented in Sweden.", "doi": "10.3390/ijerph17228491", "pmid": "33207786", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "ijerph17228491"}], "notes": [], "created": "2020-11-27T09:52:00.784Z", "modified": "2022-11-09T08:22:22.764Z"}, {"entity": "publication", "iuid": "0d51904ea0864a848c8ab3a0f232cc54", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d51904ea0864a848c8ab3a0f232cc54.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d51904ea0864a848c8ab3a0f232cc54"}}, "title": "COVID-19 patients in intensive care develop predominantly oliguric acute kidney injury.", "authors": [{"family": "Luther", "given": "Tomas", "initials": "T"}, {"family": "B\u00fclow-Anderberg", "given": "Sara", "initials": "S"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Rubertsson", "given": "Sten", "initials": "S"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2020-11-15", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": "65", "issue": "3", "pages": "364-372"}, "abstract": "Acute kidney injury (AKI) is a syndrome of reduced glomerular filtration rate and/or reduced urine flow associated with mortality in corona virus disease 2019 (COVID-19). AKI is often associated with renal tissue damage, which may lead to chronic kidney disease. Biomarkers of tissue damage may identify patients of particular risk.\r\n\r\nIn a prospective observational study of 57 patients admitted to intensive care, AKI incidence and characteristics was evaluated according to KDIGO criteria and related to days after admission. Urinary albumin, Neutrophil Gelatinase-Associated Lipocalin (NGAL), Kidney Injury Molecule 1 (KIM-1) and Plasma Tissue Inhibitor of MetalloProteinase 2 (TIMP-2) were analysed in 52 patients at admission. The majority (n = 51, 89%) of patients developed AKI, and 27 (47%) patients had predominantly oliguric AKI where oliguria was more severe than plasma Creatinine increase. Severe oliguria within first 2 days after admission was common (n = 37, 65%), whereas stage 2 and 3 AKI due to Creatinine occurred later than day 2 in 67% (12/18) of cases. Renal replacement therapy was started in 9 (16%) patients, and 30-day mortality was 28%. Urinary biomarkers were increased in a majority of patients, but did not robustly predict KDIGO stage. Most patients had microalbuminuria, and severe albuminuria (albumin Creatinine ratio > 30 mg/mmol) was found in n = 9 (17%) patients.\r\n\r\nA majority of patients with COVID-19 admitted to the ICU develop AKI. The functional deficit is often low urinary volume, and initial levels of biomarkers are generally increased without clear relation to final AKI stage.", "doi": "10.1111/aas.13746", "pmid": "33190222", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT04316884", "description": null}], "notes": [], "created": "2020-11-30T16:21:03.364Z", "modified": "2021-06-13T14:16:05.611Z"}, {"entity": "publication", "iuid": "80604ed113e244199546e41b2aaeb597", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/80604ed113e244199546e41b2aaeb597.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/80604ed113e244199546e41b2aaeb597"}}, "title": "Progress report on new antiepileptic drugs: A summary of the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV). I. Drugs in preclinical and early clinical development.", "authors": [{"family": "Bialer", "given": "Meir", "initials": "M"}, {"family": "Johannessen", "given": "Svein I", "initials": "SI"}, {"family": "Koepp", "given": "Matthias J", "initials": "MJ"}, {"family": "Levy", "given": "Ren\u00e9 H", "initials": "RH"}, {"family": "Perucca", "given": "Emilio", "initials": "E"}, {"family": "Perucca", "given": "Piero", "initials": "P"}, {"family": "Tomson", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "White", "given": "H Steve", "initials": "HS"}], "type": "journal article", "published": "2020-11-14", "journal": {"title": "Epilepsia", "issn": "1528-1167", "volume": null, "issue": null, "pages": null, "issn-l": "0013-9580"}, "abstract": "Since 1992, the Eilat Conferences have provided a forum for all stakeholders in the epilepsy community to appraise the latest data on new antiepileptic drugs and emergency seizure treatments, including, in recent years, updates on progress with the development of novel monitoring and therapeutic devices. Because of the COVID-19 pandemic, the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV) was held as a fully virtual conference on July 27-30, 2020 for the sessions on drugs and on August 3, 2020 for the sessions on devices, and was attended during the 5 days by >500 participants from 63 countries. This progress report summarizes key preclinical and initial (phase 1) clinical data on eight investigational treatments that are currently in early development, including 2-deoxy-D-glucose, GAO-3-02, JNJ-40411813, NBI-921352, NTX-001, sec-butylpropylacetamide, XEN1101, and XEN496. This report provides an overview of current scenarios in the area of treatment discovery and development. The information presented illustrates a variety of innovative strategies, including exploration of compounds with novel mechanisms of action, transplantation of interneurons into epileptogenic brain regions, and the targeting of rare, previously neglected syndromes.", "doi": "10.1111/epi.16725", "pmid": "33190243", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-27T09:56:44.967Z", "modified": "2020-11-27T09:57:08.067Z"}, {"entity": "publication", "iuid": "098e78feb6644af587ed79f4227ad801", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/098e78feb6644af587ed79f4227ad801.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/098e78feb6644af587ed79f4227ad801"}}, "title": "Mortality in Norway and Sweden before and after the Covid-19 outbreak: a cohort study", "authors": [{"family": "Juul", "given": "Frederik E", "initials": "FE"}, {"family": "Jodal", "given": "Henriette C", "initials": "HC"}, {"family": "Barua", "given": "Ishita", "initials": "I"}, {"family": "Refsum", "given": "Erle", "initials": "E"}, {"family": "Olsvik", "given": "\u00d8rjan", "initials": "\u00d8"}, {"family": "Helsingen", "given": "Lise M", "initials": "LM"}, {"family": "L\u00f8berg", "given": "Magnus", "initials": "M"}, {"family": "Bretthauer", "given": "Michael", "initials": "M"}, {"family": "Kalager", "given": "Mette", "initials": "M"}, {"family": "Emilsson", "given": "Louise", "initials": "L"}], "type": "posted-content", "published": "2020-11-13", "journal": {"title": "", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.11.11.20229708", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-10T04:25:00.880Z", "modified": "2021-06-10T04:25:46.265Z"}, {"entity": "publication", "iuid": "7c3d20509f2741158f4b2fd57038223d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7c3d20509f2741158f4b2fd57038223d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7c3d20509f2741158f4b2fd57038223d"}}, "title": "JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality.", "authors": [{"family": "Stebbing", "given": "Justin", "initials": "J"}, {"family": "S\u00e1nchez Nievas", "given": "Gin\u00e9s", "initials": "G"}, {"family": "Falcone", "given": "Marco", "initials": "M"}, {"family": "Youhanna", "given": "Sonia", "initials": "S"}, {"family": "Richardson", "given": "Peter", "initials": "P"}, {"family": "Ottaviani", "given": "Silvia", "initials": "S"}, {"family": "Shen", "given": "Joanne X", "initials": "JX"}, {"family": "Sommerauer", "given": "Christian", "initials": "C"}, {"family": "Tiseo", "given": "Giusy", "initials": "G"}, {"family": "Ghiadoni", "given": "Lorenzo", "initials": "L"}, {"family": "Virdis", "given": "Agostino", "initials": "A"}, {"family": "Monzani", "given": "Fabio", "initials": "F"}, {"family": "Rizos", "given": "Luis Romero", "initials": "LR"}, {"family": "Forfori", "given": "Francesco", "initials": "F"}, {"family": "Avenda\u00f1o-C\u00e9spedes", "given": "Almudena", "initials": "A"}, {"family": "De Marco", "given": "Salvatore", "initials": "S"}, {"family": "Carrozzi", "given": "Laura", "initials": "L"}, {"family": "Lena", "given": "Fabio", "initials": "F"}, {"family": "S\u00e1nchez-Jurado", "given": "Pedro Manuel", "initials": "PM"}, {"family": "Lacerenza", "given": "Leonardo Gianluca", "initials": "LG"}, {"family": "Cesira", "given": "Nencioni", "initials": "N"}, {"family": "Caldevilla-Bernardo", "given": "David", "initials": "D"}, {"family": "Perrella", "given": "Antonio", "initials": "A"}, {"family": "Niccoli", "given": "Laura", "initials": "L"}, {"family": "M\u00e9ndez", "given": "Lourdes S\u00e1ez", "initials": "LS"}, {"family": "Matarrese", "given": "Daniela", "initials": "D"}, {"family": "Goletti", "given": "Delia", "initials": "D"}, {"family": "Tan", "given": "Yee-Joo", "initials": "Y"}, {"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Dranitsaris", "given": "George", "initials": "G"}, {"family": "Cantini", "given": "Fabrizio", "initials": "F"}, {"family": "Farcomeni", "given": "Alessio", "initials": "A"}, {"family": "Dutta", "given": "Shuchismita", "initials": "S"}, {"family": "Burley", "given": "Stephen K", "initials": "SK"}, {"family": "Zhang", "given": "Haibo", "initials": "H"}, {"family": "Pistello", "given": "Mauro", "initials": "M"}, {"family": "Li", "given": "William", "initials": "W"}, {"family": "Mas Romero", "given": "Marta", "initials": "M"}, {"family": "Andr\u00e9s Pretel", "given": "Fernando", "initials": "F"}, {"family": "Sim\u00f3n-Talero", "given": "Rafaela S\u00e1nchez", "initials": "RS"}, {"family": "Garc\u00eda-Molina", "given": "Rafael", "initials": "R"}, {"family": "Kutter", "given": "Claudia", "initials": "C"}, {"family": "Felce", "given": "James H", "initials": "JH"}, {"family": "Nizami", "given": "Zehra F", "initials": "ZF"}, {"family": "Miklosi", "given": "Andras G", "initials": "AG"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}, {"family": "Menichetti", "given": "Francesco", "initials": "F"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Abizanda", "given": "Pedro", "initials": "P"}, {"family": "Lauschke", "given": "Volker M", "initials": "VM"}], "type": "journal article", "published": "2020-11-13", "journal": {"title": "Sci Adv", "issn": "2375-2548", "issn-l": "2375-2548", "volume": "7", "issue": "1", "pages": null}, "abstract": "Using AI we identified baricitinib as possessing anti-viral and anti-cytokine efficacy. We now show a 71% (95% CI 0.15-0.58) mortality benefit in 83 patients with moderate-severe SARS-CoV-2 pneumonia with few drug-induced adverse events, including a large elderly cohort (median age 81 years). A further 48 cases with mild-moderate pneumonia recovered uneventfully. Using organotypic 3D cultures of primary human liver cells, we demonstrate that interferon-alpha-2 (IFN\u03b12) significantly increases ACE2 expression and SARS-CoV-2 infectivity in parenchymal cells by >5-fold. RNA-Seq reveals gene response signatures associated with platelet activation, fully inhibited by baricitinib. Using viral load quantifications and super-resolution microscopy, baricitinib exerts activity rapidly through the inhibition of host proteins (numb associated kinases), uniquely amongst anti-virals. This reveals mechanistic actions of a Janus kinase-1/2 inhibitor targeting viral entry, replication and the cytokine storm, and is associated with beneficial outcomes including in severely ill elderly patients, data that incentivizes further randomized controlled trials.", "doi": "10.1126/sciadv.abe4724", "pmid": "33187978", "labels": {"Type: Journal article": null, "Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-9711/", "description": "Array Express E-MTAB-9711: RNA-seq of SARS-CoV-2-infected human primary hepatocyte-derived spheroids upon interferon a2 and baricitinib treatment"}, {"db": "URL", "key": "http://advances.sciencemag.org/cgi/content/full/sciadv.abe4724/DC1", "description": "Supplementary information"}], "notes": [], "created": "2020-11-18T15:27:10.197Z", "modified": "2021-06-13T14:16:56.042Z"}, {"entity": "publication", "iuid": "ea3e7e32fe0a47af92fac82feeace707", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ea3e7e32fe0a47af92fac82feeace707.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ea3e7e32fe0a47af92fac82feeace707"}}, "title": "The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19.", "authors": [{"family": "Consiglio", "given": "Camila Rosat", "initials": "CR", "orcid": "0000-0002-8901-2328", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/583a255a08b64095b9c4642911e1a922.json"}}, {"family": "Cotugno", "given": "Nicola", "initials": "N", "orcid": "0000-0002-7748-1581", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e39b95146ec4289b4efd91f869e2853.json"}}, {"family": "Sardh", "given": "Fabian", "initials": "F"}, {"family": "Pou", "given": "Christian", "initials": "C"}, {"family": "Amodio", "given": "Donato", "initials": "D", "orcid": "0000-0003-4550-3018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8036babccffd453ab3dda55c13a204fa.json"}}, {"family": "Rodriguez", "given": "Lucie", "initials": "L", "orcid": "0000-0002-3692-9060", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47b10420d4f449929ff0221bf881c7c4.json"}}, {"family": "Tan", "given": "Ziyang", "initials": "Z"}, {"family": "Zicari", "given": "Sonia", "initials": "S", "orcid": "0000-0003-1240-8057", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0379fd354fd3492aa5d5fe8ea9e16065.json"}}, {"family": "Ruggiero", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-1041-7489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e47b6216d0514a37818f676dce75ff57.json"}}, {"family": "Pascucci", "given": "Giuseppe Rubens", "initials": "GR", "orcid": "0000-0002-5978-1193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cfa33536b1242949e2195412e11f541.json"}}, {"family": "Santilli", "given": "Veronica", "initials": "V"}, {"family": "Campbell", "given": "Tessa", "initials": "T"}, {"family": "Bryceson", "given": "Yenan", "initials": "Y"}, {"family": "Eriksson", "given": "Daniel", "initials": "D"}, {"family": "Wang", "given": "Jun", "initials": "J"}, {"family": "Marchesi", "given": "Alessandra", "initials": "A"}, {"family": "Lakshmikanth", "given": "Tadepally", "initials": "T", "orcid": "0000-0001-7256-5770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a119d704e3594d66ae78021072a8f9ba.json"}}, {"family": "Campana", "given": "Andrea", "initials": "A"}, {"family": "Villani", "given": "Alberto", "initials": "A", "orcid": "0000-0002-9120-0424", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5005156054ed4498b7d938cbb7caf42e.json"}}, {"family": "Rossi", "given": "Paolo", "initials": "P"}, {"family": "CACTUS Study Team", "given": "", "initials": ""}, {"family": "Landegren", "given": "Nils", "initials": "N"}, {"family": "Palma", "given": "Paolo", "initials": "P", "orcid": "0000-0002-3066-4719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36e1a02e86a142c2b2d131154fb46f1c.json"}}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}], "type": "journal article", "published": "2020-11-12", "journal": {"title": "Cell", "issn": "1097-4172", "issn-l": "0092-8674", "volume": "183", "issue": "4", "pages": "968-981.e7"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is typically very mild and often asymptomatic in children. A complication is the rare multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, presenting 4-6 weeks after infection as high fever, organ dysfunction, and strongly elevated markers of inflammation. The pathogenesis is unclear but has overlapping features with Kawasaki disease suggestive of vasculitis and a likely autoimmune etiology. We apply systems-level analyses of blood immune cells, cytokines, and autoantibodies in healthy children, children with Kawasaki disease enrolled prior to COVID-19, children infected with SARS-CoV-2, and children presenting with MIS-C. We find that the inflammatory response in MIS-C differs from the cytokine storm of severe acute COVID-19, shares several features with Kawasaki disease, but also differs from this condition with respect to T cell subsets, interleukin (IL)-17A, and biomarkers associated with arterial damage. Finally, autoantibody profiling suggests multiple autoantibodies that could be involved in the pathogenesis of MIS-C.", "doi": "10.1016/j.cell.2020.09.016", "pmid": "32966765", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biomarkers and systems immunology": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pmc", "key": "PMC7474869"}, {"db": "pii", "key": "S0092-8674(20)31157-0"}], "notes": [], "created": "2020-10-28T09:09:22.496Z", "modified": "2023-06-19T15:18:37.668Z"}, {"entity": "publication", "iuid": "ff7aae8db2064115877b39738a00bea8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff7aae8db2064115877b39738a00bea8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff7aae8db2064115877b39738a00bea8"}}, "title": "Sleep and circadian problems during the coronavirus disease 2019 (COVID-19) pandemic: the International COVID-19 Sleep Study (ICOSS).", "authors": [{"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Chung", "given": "Frances", "initials": "F"}, {"family": "Penzel", "given": "Thomas", "initials": "T"}, {"family": "Espie", "given": "Colin A", "initials": "CA"}, {"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "ICOSS-collaboration group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-12", "journal": {"title": "J Sleep Res", "issn": "1365-2869", "volume": null, "issue": null, "pages": "e13206", "issn-l": "0962-1105"}, "abstract": "This protocol paper describes the development of an international collaboration to survey several thousand adults from different countries around the world about their sleep during the coronavirus disease 2019 (COVID-19) pandemic. It is based on the development of a harmonised survey with 50 questions (106 different items) on sleep habits and sleep symptoms that permit comparability of information. The harmonised questionnaire may be used in anonymous cross-sectional surveys, and the instruments within the questionnaire may also be used in prospective studies and clinical studies. The aim was to develop a questionnaire to sample a variety of sleep-wake disorders and other symptoms likely to be caused by prolonged social confinement or by having had COVID-19. The questionnaire was designed to be: (a) simple and, (b) free to use, for research purposes, (c) multilingual, and (d) comprehensive. It can be completed in <30 min. By the end of June 2020, the survey questionnaire had been administered in Austria, Canada, China, Finland, France, Germany, Hong Kong, Italy, Japan, Norway, Poland, Sweden, UK and USA. Research questions to be addressed by the pooled data derived from the participating sites focus on describing the nature and rates of various sleep and circadian rhythms symptoms, as well as their psychological and medical correlates, that arise at various points during the COVID-19 pandemic.", "doi": "10.1111/jsr.13206", "pmid": "33179820", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-30T16:29:23.154Z", "modified": "2020-11-30T16:29:23.163Z"}, {"entity": "publication", "iuid": "c7c21924c4be4ba2893c3de7f6790186", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7c21924c4be4ba2893c3de7f6790186.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7c21924c4be4ba2893c3de7f6790186"}}, "title": "Local topology, bifurcations and mutation hot-spots in proteins with SARS-CoV-2 spike protein as an example", "authors": [{"family": "Peng", "given": "Xubiao", "initials": "X"}, {"family": "Niemi", "given": "Antti J", "initials": "AJ"}], "type": "posted-content", "published": "2020-11-12", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.11.11.378828", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-03-08T15:03:36.462Z", "modified": "2021-04-15T19:03:01.894Z"}, {"entity": "publication", "iuid": "9c6ba4d480da4d18b2fcab1258dfd2e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9c6ba4d480da4d18b2fcab1258dfd2e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9c6ba4d480da4d18b2fcab1258dfd2e8"}}, "title": "Impact of COVID-19 pandemic on tuberculosis laboratory services in Europe.", "authors": [{"family": "Nikolayevskyy", "given": "Vlad", "initials": "V"}, {"family": "Holicka", "given": "Yen", "initials": "Y"}, {"family": "van Soolingen", "given": "Dick", "initials": "D"}, {"family": "van der Werf", "given": "Marieke J", "initials": "MJ"}, {"family": "K\u00f6dm\u00f6n", "given": "Csaba", "initials": "C"}, {"family": "Surkova", "given": "Elena", "initials": "E"}, {"family": "Hillemann", "given": "Doris", "initials": "D"}, {"family": "Groenheit", "given": "Ramona", "initials": "R"}, {"family": "Cirillo", "given": "Daniela", "initials": "D"}, {"family": "ERLTB-Net-2 study participants", "given": "", "initials": ""}], "type": "letter", "published": "2020-11-12", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "volume": null, "issue": null, "issn-l": "0903-1936"}, "abstract": null, "doi": "10.1183/13993003.03890-2020", "pmid": "33184119", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "13993003.03890-2020"}, {"db": "pmc", "key": "PMC7670866"}], "notes": [], "created": "2020-11-30T16:31:37.720Z", "modified": "2020-11-30T16:31:37.730Z"}, {"entity": "publication", "iuid": "10a1d6d31cd04809a438e3081949f053", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/10a1d6d31cd04809a438e3081949f053.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/10a1d6d31cd04809a438e3081949f053"}}, "title": "Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial.", "authors": [{"family": "Ponikowski", "given": "Piotr", "initials": "P"}, {"family": "Kirwan", "given": "Bridget-Anne", "initials": "BA"}, {"family": "Anker", "given": "Stefan D", "initials": "SD"}, {"family": "McDonagh", "given": "Theresa", "initials": "T"}, {"family": "Dorobantu", "given": "Maria", "initials": "M"}, {"family": "Drozdz", "given": "Jaros\u0142aw", "initials": "J"}, {"family": "Fabien", "given": "Vincent", "initials": "V"}, {"family": "Filippatos", "given": "Gerasimos", "initials": "G"}, {"family": "G\u00f6hring", "given": "Udo Michael", "initials": "UM"}, {"family": "Keren", "given": "Andre", "initials": "A"}, {"family": "Khintibidze", "given": "Irakli", "initials": "I"}, {"family": "Kragten", "given": "Hans", "initials": "H"}, {"family": "Martinez", "given": "Felipe A", "initials": "FA"}, {"family": "Metra", "given": "Marco", "initials": "M"}, {"family": "Milicic", "given": "Davor", "initials": "D"}, {"family": "Nicolau", "given": "Jos\u00e9 C", "initials": "JC"}, {"family": "Ohlsson", "given": "Marcus", "initials": "M"}, {"family": "Parkhomenko", "given": "Alexander", "initials": "A"}, {"family": "Pascual-Figal", "given": "Domingo A", "initials": "DA"}, {"family": "Ruschitzka", "given": "Frank", "initials": "F"}, {"family": "Sim", "given": "David", "initials": "D"}, {"family": "Skouri", "given": "Hadi", "initials": "H"}, {"family": "van der Meer", "given": "Peter", "initials": "P"}, {"family": "Lewis", "given": "Basil S", "initials": "BS"}, {"family": "Comin-Colet", "given": "Josep", "initials": "J"}, {"family": "von Haehling", "given": "Stephan", "initials": "S"}, {"family": "Cohen-Solal", "given": "Alain", "initials": "A"}, {"family": "Danchin", "given": "Nicolas", "initials": "N"}, {"family": "Doehner", "given": "Wolfram", "initials": "W"}, {"family": "Dargie", "given": "Henry J", "initials": "HJ"}, {"family": "Motro", "given": "Michael", "initials": "M"}, {"family": "Butler", "given": "Javed", "initials": "J"}, {"family": "Friede", "given": "Tim", "initials": "T"}, {"family": "Jensen", "given": "Klaus H", "initials": "KH"}, {"family": "Pocock", "given": "Stuart", "initials": "S"}, {"family": "Jankowska", "given": "Ewa A", "initials": "EA"}, {"family": "AFFIRM-AHF investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-12", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "396", "issue": "10266", "pages": "1895-1904", "issn-l": "0140-6736"}, "abstract": "Intravenous ferric carboxymaltose has been shown to improve symptoms and quality of life in patients with chronic heart failure and iron deficiency. We aimed to evaluate the effect of ferric carboxymaltose, compared with placebo, on outcomes in patients who were stabilised after an episode of acute heart failure.\n\nAFFIRM-AHF was a multicentre, double-blind, randomised trial done at 121 sites in Europe, South America, and Singapore. Eligible patients were aged 18 years or older, were hospitalised for acute heart failure with concomitant iron deficiency (defined as ferritin <100 \u03bcg/L, or 100-299 \u03bcg/L with transferrin saturation <20%), and had a left ventricular ejection fraction of less than 50%. Before hospital discharge, participants were randomly assigned (1:1) to receive intravenous ferric carboxymaltose or placebo for up to 24 weeks, dosed according to the extent of iron deficiency. To maintain masking of patients and study personnel, treatments were administered in black syringes by personnel not involved in any study assessments. The primary outcome was a composite of total hospitalisations for heart failure and cardiovascular death up to 52 weeks after randomisation, analysed in all patients who received at least one dose of study treatment and had at least one post-randomisation data point. Secondary outcomes were the composite of total cardiovascular hospitalisations and cardiovascular death; cardiovascular death; total heart failure hospitalisations; time to first heart failure hospitalisation or cardiovascular death; and days lost due to heart failure hospitalisations or cardiovascular death, all evaluated up to 52 weeks after randomisation. Safety was assessed in all patients for whom study treatment was started. A pre-COVID-19 sensitivity analysis on the primary and secondary outcomes was prespecified. This study is registered with ClinicalTrials.gov, NCT02937454, and has now been completed.\n\nBetween March 21, 2017, and July 30, 2019, 1525 patients were screened, of whom 1132 patients were randomly assigned to study groups. Study treatment was started in 1110 patients, and 1108 (558 in the carboxymaltose group and 550 in the placebo group) had at least one post-randomisation value. 293 primary events (57\u00b72 per 100 patient-years) occurred in the ferric carboxymaltose group and 372 (72\u00b75 per 100 patient-years) occurred in the placebo group (rate ratio [RR] 0\u00b779, 95% CI 0\u00b762-1\u00b701, p=0\u00b7059). 370 total cardiovascular hospitalisations and cardiovascular deaths occurred in the ferric carboxymaltose group and 451 occurred in the placebo group (RR 0\u00b780, 95% CI 0\u00b764-1\u00b700, p=0\u00b7050). There was no difference in cardiovascular death between the two groups (77 [14%] of 558 in the ferric carboxymaltose group vs 78 [14%] in the placebo group; hazard ratio [HR] 0\u00b796, 95% CI 0\u00b770-1\u00b732, p=0\u00b781). 217 total heart failure hospitalisations occurred in the ferric carboxymaltose group and 294 occurred in the placebo group (RR 0\u00b774; 95% CI 0\u00b758-0\u00b794, p=0\u00b7013). The composite of first heart failure hospitalisation or cardiovascular death occurred in 181 (32%) patients in the ferric carboxymaltose group and 209 (38%) in the placebo group (HR 0\u00b780, 95% CI 0\u00b766-0\u00b798, p=0\u00b7030). Fewer days were lost due to heart failure hospitalisations and cardiovascular death for patients assigned to ferric carboxymaltose compared with placebo (369 days per 100 patient-years vs 548 days per 100 patient-years; RR 0\u00b767, 95% CI 0\u00b747-0\u00b797, p=0\u00b7035). Serious adverse events occurred in 250 (45%) of 559 patients in the ferric carboxymaltose group and 282 (51%) of 551 patients in the placebo group.\n\nIn patients with iron deficiency, a left ventricular ejection fraction of less than 50%, and who were stabilised after an episode of acute heart failure, treatment with ferric carboxymaltose was safe and reduced the risk of heart failure hospitalisations, with no apparent effect on the risk of cardiovascular death.\n\nVifor Pharma.", "doi": "10.1016/S0140-6736(20)32339-4", "pmid": "33197395", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT02937454"}], "notes": [], "created": "2020-11-27T10:49:53.803Z", "modified": "2021-02-26T08:45:47.859Z"}, {"entity": "publication", "iuid": "8658ad0b159241be8e65c5b4f84da1dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8658ad0b159241be8e65c5b4f84da1dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8658ad0b159241be8e65c5b4f84da1dd"}}, "title": "Treating exuberant, non-resolving inflammation in the lung; Implications for acute respiratory distress syndrome and COVID-19.", "authors": [{"family": "Gilroy", "given": "Derek W", "initials": "DW"}, {"family": "De Maeyer", "given": "Roel P H", "initials": "RPH"}, {"family": "Tepper", "given": "Mark", "initials": "M"}, {"family": "O'Brien", "given": "Alastair", "initials": "A"}, {"family": "Uddin", "given": "Mohib", "initials": "M"}, {"family": "Chen", "given": "Judy", "initials": "J"}, {"family": "Goldstein", "given": "Daniel R", "initials": "DR"}, {"family": "Akbar", "given": "Arne N", "initials": "AN"}], "type": "journal article", "published": "2020-11-11", "journal": {"title": "Pharmacol Ther", "issn": "1879-016X", "volume": null, "issue": null, "pages": "107745", "issn-l": "0163-7258"}, "abstract": "While COVID-19, the disease driven by SARS-CoV-2 has ignited interest in the host immune response to this infection, it has also highlighted the lack of treatment options for the damaging inflammatory responses driven by pathogens that precipitate the acute respiratory distress syndrome (ARDS). With the global prevalence of SARS-CoV-2 and the likelihood of a second winter spike alongside seasonal flu, the need for effective and targeted anti-inflammatory agents is even more pressing. Here we discuss the aetiology of COVID-19 and the common signalling pathways driven by SARS-CoV-2, namely p38 MAP kinase. We highlight that p38 MAP kinase becomes elevated with increasing age, thereby driving many of the inflammatory pathways that precipitate death in old people with the added drawback of impairing vaccine efficacy in this susceptible age group. Finally, we review drugs available to inhibit p38 MAP kinase, their risks-versus-benefits as well as suggested dosing regimen to combat over-exuberant innate immune responses and potentially reverse vaccine inefficacy in older patients.", "doi": "10.1016/j.pharmthera.2020.107745", "pmid": "33188794", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0163-7258(20)30276-X"}, {"db": "pmc", "key": "PMC7657264"}], "notes": [], "created": "2020-11-27T11:01:14.577Z", "modified": "2020-11-27T11:03:48.877Z"}, {"entity": "publication", "iuid": "325ff1ba4f774ef5a692444fdd4878c1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/325ff1ba4f774ef5a692444fdd4878c1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/325ff1ba4f774ef5a692444fdd4878c1"}}, "title": "Long-distance airborne dispersal of SARS-CoV-2 in COVID-19 wards.", "authors": [{"family": "Nissen", "given": "Karolina", "initials": "K"}, {"family": "Krambrich", "given": "Janina", "initials": "J"}, {"family": "Akaberi", "given": "Dario", "initials": "D"}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Svensson", "given": "Lennart", "initials": "L"}, {"family": "Salaneck", "given": "Erik", "initials": "E"}], "type": "journal article", "published": "2020-11-11", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "10", "issue": "1", "pages": "19589"}, "abstract": "Evidence suggests that SARS-CoV-2, as well as other coronaviruses, can be dispersed and potentially transmitted by aerosols directly or via ventilation systems. We therefore investigated ventilation openings in one COVID-19 ward and central ducts that expel indoor air from three COVID-19 wards at Uppsala University Hospital, Sweden, during April and May 2020. Swab samples were taken from individual ceiling ventilation openings and surfaces in central ducts. Samples were subsequently subjected to rRT-PCR targeting the N and E genes of SARS-CoV-2. Central ventilation HEPA filters, located several stories above the wards, were removed and portions analyzed in the same manner. In two subsequent samplings, SARS-CoV-2 N and E genes were detected in seven and four out of 19 room vents, respectively. Central ventilation HEPA exhaust filters from the ward were found positive for both genes in three samples. Corresponding filters from two other, adjacent COVID-19 wards were also found positive. Infective ability of the samples was assessed by inoculation of susceptible cell cultures but could not be determined in these experiments. Detection of SARS-CoV-2 in central ventilation systems, distant from patient areas, indicate that virus can be transported long distances and that droplet transmission alone cannot reasonably explain this, especially considering the relatively low air change rates in these wards. Airborne transmission of SARS-CoV-2 must be taken into consideration for preventive measures.", "doi": "10.1038/s41598-020-76442-2", "pmid": "33177563", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-020-76442-2"}, {"db": "pmc", "key": "PMC7659316"}], "notes": [], "created": "2020-11-17T18:03:38.168Z", "modified": "2021-02-26T08:45:48.027Z"}, {"entity": "publication", "iuid": "028acc5d3ea24aa7b79c54b661dfed8d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/028acc5d3ea24aa7b79c54b661dfed8d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/028acc5d3ea24aa7b79c54b661dfed8d"}}, "title": "In silico and In vitro Studies Reveal Complement System Drives Coagulation Cascade in SARS-CoV-2 Pathogenesis.", "authors": [{"family": "Tiwari", "given": "Ritudhwaj", "initials": "R"}, {"family": "Mishra", "given": "Anurag R", "initials": "AR"}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "Gupta", "given": "Soham", "initials": "S"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}, {"family": "Nayak", "given": "Debasis", "initials": "D"}], "type": "journal article", "published": "2020-11-11", "journal": {"title": "Comput Struct Biotechnol J", "issn": "2001-0370", "volume": "18", "issue": null, "pages": "3734-3744", "issn-l": "2001-0370"}, "abstract": "The emergence and continued spread of SARS-CoV-2 have resulted in a public health emergency across the globe. The lack of knowledge on the precise mechanism of viral pathogenesis is impeding medical intervention. In this study, we have taken both in silico and in vitro experimental approaches to unravel the mechanism of viral pathogenesis associated with complement and coagulation pathways. Based on the structural similarities of viral and host proteins, we initially generated a protein-protein interactome profile. Further computational analysis combined with Gene Ontology (GO) analysis and KEGG pathway analysis predicted key annotated pathways associated with viral pathogenesis. These include MAPK signaling, complement, and coagulation cascades, endocytosis, PD-L1 expression, PD-1 checkpoint pathway in cancer and C-type lectin receptor signaling pathways. Degree centrality analysis pinned down to MAPK1, MAPK3, AKT1, and SRC are crucial drivers of signaling pathways and often overlap with the associated pathways. Most strikingly, the complement and coagulation cascade and platelet activation pathways are interconnected, presumably directing thrombotic activity observed in severe or critical cases of COVID-19. This is complemented by in vitro studies of Huh7 cell infection and analysis of the transcriptome and proteomic profile of gene candidates during viral infection. The most known candidates associated with complement and coagulation cascade signaling by KEGG pathway analysis showed significant up-regulated fold change during viral infection. Collectively both in silico and in vitro studies suggest complement and coagulation cascade signaling are a mechanism for intravascular coagulation, thrombotic changes, and associated complications in severe COVID-19 patients.", "doi": "10.1016/j.csbj.2020.11.005", "pmid": "33200027", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S2001-0370(20)30472-4"}, {"db": "pmc", "key": "PMC7657020"}], "notes": [], "created": "2020-11-19T19:43:58.111Z", "modified": "2021-04-23T15:18:24.542Z"}, {"entity": "publication", "iuid": "2042fa0ab0d14783b368a9ac51642f96", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2042fa0ab0d14783b368a9ac51642f96.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2042fa0ab0d14783b368a9ac51642f96"}}, "title": "How the Covid-19 pandemic is impacting sexual and reproductive health and rights and response: results from a global survey of providers, researchers, and policy makers.", "authors": [{"family": "Endler", "given": "Margit", "initials": "M"}, {"family": "Al-Haidari", "given": "Taghreed", "initials": "T"}, {"family": "Benedetto", "given": "Chiara", "initials": "C"}, {"family": "Chowdhury", "given": "Sameena", "initials": "S"}, {"family": "Christilaw", "given": "Jan", "initials": "J"}, {"family": "El Kak", "given": "Faysal", "initials": "F"}, {"family": "Galimberti", "given": "Diana", "initials": "D"}, {"family": "Garcia-Moreno", "given": "Claudia", "initials": "C"}, {"family": "Gutierrez", "given": "Miguel", "initials": "M"}, {"family": "Ibrahim", "given": "Shaimaa", "initials": "S"}, {"family": "Kumari", "given": "Shantha", "initials": "S"}, {"family": "McNicholas", "given": "Colleen", "initials": "C"}, {"family": "Mostajo Flores", "given": "Desir\u00e9e", "initials": "D"}, {"family": "Muganda", "given": "John", "initials": "J"}, {"family": "Ramirez-Negrin", "given": "Atziri", "initials": "A"}, {"family": "Senanayake", "given": "Hemantha", "initials": "H"}, {"family": "Sohail", "given": "Rubina", "initials": "R"}, {"family": "Temmerman", "given": "Marleen", "initials": "M"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}], "type": "journal article", "published": "2020-11-11", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": null, "issue": null, "issn-l": "0001-6349"}, "abstract": "We aimed to give a global overview of trends in access to sexual and reproductive health and rights (SRHR) during the Covid-19 pandemic and what is being done to mitigate its impact.\n\nWe performed a descriptive analysis and content analysis based on an online survey among clinicians, researchers and organizations. Our data was extracted from multiple-choice questions on access to SRHR services and risk of SRHR violations, and written responses to open-ended questions on threats to access and required response.\n\nThe survey was answered by 51 people representing 29 countries. 86% reported that access to contraceptive services was less or much less due to Covid-19, corresponding figures for surgical and medical abortion were 62% and 46%. The increased risk of gender-based and sexual violence was assessed as moderate or severe by 79%. Among countries with mildly restrictive abortion policies, 69% had implemented changes to facilitate access to abortion during the pandemic, compared to 0 among countries with severe restrictions (p<0.001), 87.5% compared to 46% had implemented changes to facilitate access to contraception (p= 0.023). The content analysis showed that i) prioritizations in health service delivery at the expense of SRHR, ii) lack of political will, iii) the detrimental effect of lock-down, and iv) the suspension of sexual education, were threats to SRHR access (theme 1). Requirements to mitigate these threats (theme 2) were i) political will and support of universal access to SRH services, ii) the sensitization of providers, vii) free public transport, and viii) physical protective equipment. A contrasting third theme was the state of exception of the Covid-19 pandemic as a window of opportunity to push forward women\u00b4s health and rights.\n\nMany countries have seen decreased access to and increased violations of SRHR during the Covid-19 pandemic. Countries with severe restrictions on abortion seem less likely to have implemented changes to SRHR delivery to mitigate this impact. Political will to support the advancement of SRHR is often lacking, which is fundamental to ensuring both continued access and, in a minority of cases, the solidification of gains made to SRHR during the pandemic.", "doi": "10.1111/aogs.14043", "pmid": "33179265", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-27T10:00:02.800Z", "modified": "2020-11-30T16:29:54.257Z"}, {"entity": "publication", "iuid": "dbfda0fdcd6d401ba68a4be038469ab5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dbfda0fdcd6d401ba68a4be038469ab5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dbfda0fdcd6d401ba68a4be038469ab5"}}, "title": "The issues of individualized medicine and pharmacovigilance: A consideration of COVID-19 and vaccination.", "authors": [{"family": "Ralph Edwards", "given": "I", "initials": "I"}, {"family": "Lindquist", "given": "Marie", "initials": "M"}], "type": "editorial", "published": "2020-11-10", "journal": {"title": "Int J Risk Saf Med", "issn": "1878-6847", "volume": "31", "issue": "4", "pages": "179-180", "issn-l": null}, "abstract": null, "doi": "10.3233/JRS-201008", "pmid": "33164947", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "JRS201008"}], "notes": [], "created": "2020-11-30T16:32:52.920Z", "modified": "2020-11-30T16:32:52.943Z"}, {"entity": "publication", "iuid": "af559716c7364d0bb301d8ef4144a058", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/af559716c7364d0bb301d8ef4144a058.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/af559716c7364d0bb301d8ef4144a058"}}, "title": "Surveillance of wastewater revealed peaks of SARS-CoV-2 preceding those of hospitalized patients with COVID-19.", "authors": [{"family": "Saguti", "given": "Fredy", "initials": "F"}, {"family": "Magnil", "given": "Ellen", "initials": "E"}, {"family": "Enache", "given": "Lucica", "initials": "L"}, {"family": "Churqui", "given": "Marianela Patzi", "initials": "MP"}, {"family": "Johansson", "given": "Anette", "initials": "A"}, {"family": "Lumley", "given": "Douglas", "initials": "D"}, {"family": "Davidsson", "given": "Fredrik", "initials": "F"}, {"family": "Dotevall", "given": "Leif", "initials": "L"}, {"family": "Mattsson", "given": "Ann", "initials": "A"}, {"family": "Trybala", "given": "Edward", "initials": "E"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Brezicka", "given": "Thomas", "initials": "T"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Norder", "given": "Hel\u00e9ne", "initials": "H"}], "type": "journal article", "published": "2020-11-10", "journal": {"title": "Water Res", "issn": "1879-2448", "issn-l": "0043-1354", "volume": "189", "issue": null, "pages": "116620"}, "abstract": "SARS-CoV-2 was discovered among humans in Wuhan, China in late 2019, and then spread rapidly, causing a global pandemic. The virus was found to be transmitted mainly by respiratory droplets from infected persons or by direct contact. It was also shown to be excreted in feces, why we investigated whether the virus could be detected in wastewater and if so, to which extent its levels reflects its spread in society. Samples of wastewater from the city of Gothenburg, and surrounding municipalities in Sweden were collected daily from mid-February until June 2020 at the Rya wastewater treatment plant. Flow proportional samples of wastewater were collected to ensure that comparable amounts were obtained for analysis. Daily samples were pooled into weekly samples. Virus was concentrated on a filter and analyzed by RT-qPCR. The amount of SARS-CoV-2 varied with peaks approximately every four week, preceding variations in number of newly hospitalized patients by 19-21 days. At that time virus testing for COVID-19 was limited to patients with severe symptoms. Local differences in viral spread was shown by analyzing weekly composite samples of wastewater from five sampling sites for four weeks. The highest amount of virus was found from the central, eastern, and northern parts of the city. SARS-CoV-2 was also found in the treated effluent wastewater from the WWTP discharged into the recipient, the G\u00f6ta River, although with a reduction of 4-log 10. The viral peaks with regular temporal intervals indicated that SARS-CoV-2 may have a cluster spread, probably reflecting that the majority of infected persons only spread the disease during a few days. Our results are important for both the planning of hospital care and to rapidly identify and intervene against local spread of the virus.", "doi": "10.1016/j.watres.2020.116620", "pmid": "33212338", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "NA", "key": "Provided in the article: amount of SARS-CoV-2 in wastewater in Gothenburg per week between February and June 2020", "description": null}], "notes": [], "created": "2020-11-24T07:37:09.624Z", "modified": "2021-02-26T08:46:13.439Z"}, {"entity": "publication", "iuid": "675c2e887707441982f23b3e80461e80", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/675c2e887707441982f23b3e80461e80.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/675c2e887707441982f23b3e80461e80"}}, "title": "Purchasing, consumption, demographic and socioeconomic variables associated with shifts in alcohol consumption during the COVID-19 pandemic.", "authors": [{"family": "Callinan", "given": "Sarah", "initials": "S"}, {"family": "Mojica-Perez", "given": "Yvette", "initials": "Y"}, {"family": "Wright", "given": "Cassandra J C", "initials": "CJC"}, {"family": "Livingston", "given": "Michael", "initials": "M"}, {"family": "Kuntsche", "given": "Sandra", "initials": "S"}, {"family": "Laslett", "given": "Anne-Marie", "initials": "A"}, {"family": "Room", "given": "Robin", "initials": "R"}, {"family": "Kuntsche", "given": "Emmanuel", "initials": "E"}], "type": "journal article", "published": "2020-11-10", "journal": {"title": "Drug Alcohol Rev", "issn": "1465-3362", "issn-l": "0959-5236", "volume": null, "issue": null, "pages": null}, "abstract": "Restrictions introduced to reduce the spread of COVID-19 have had major impacts on the living circumstances of Australians. This paper aims to provide insight into shifts in alcohol consumption and associated factors during the epidemic.\r\n\r\nA cross-sectional convenience sample of 2307 Australians aged 18 and over who drank at least monthly was recruited through social media. Respondents were asked about their alcohol consumption and purchasing in 2019 prior to the epidemic plus similar questions about their experiences in the month prior to being surveyed between 29 April and 16 May 2020.\r\n\r\nReports of average consumption before (3.53 drinks per day [3.36, 3.71 95% confidence interval]) and during (3.52 [3.34, 3.69]) the pandemic were stable. However, young men and those who drank more outside the home in 2019 reported decreased consumption during the pandemic, and people with high levels of stress and those who bulk-bought alcohol when restrictions were announced reported an increase in consumption relative to those who did not.\r\n\r\nA reported increase in consumption among those experiencing more stress suggests that some people may have been drinking to cope during the epidemic. Conversely, the reported decrease in consumption among those who drank more outside of their home in 2019 suggests that closing all on-trade sales did not result in complete substitution of on-premise drinking with home drinking in this group. Monitoring of relevant subgroups to assess long-term changes in consumption in the aftermath of the epidemic is recommended.", "doi": "10.1111/dar.13200", "pmid": "33170976", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2020-11-27T10:01:48.823Z", "modified": "2021-02-26T08:47:00.003Z"}, {"entity": "publication", "iuid": "a47dbc0890e6411dbb49a80752e594ad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a47dbc0890e6411dbb49a80752e594ad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a47dbc0890e6411dbb49a80752e594ad"}}, "title": "EAES Recommendations for Recovery Plan in Minimally Invasive Surgery Amid COVID-19 Pandemic.", "authors": [{"family": "Arezzo", "given": "Alberto", "initials": "A"}, {"family": "Francis", "given": "Nader", "initials": "N"}, {"family": "Mintz", "given": "Yoav", "initials": "Y"}, {"family": "Adamina", "given": "Michel", "initials": "M"}, {"family": "Antoniou", "given": "Stavros A", "initials": "SA"}, {"family": "Bouvy", "given": "Nicole", "initials": "N"}, {"family": "Copaescu", "given": "Catalin", "initials": "C"}, {"family": "de Manzini", "given": "Nicol\u00f2", "initials": "N"}, {"family": "Di Lorenzo", "given": "Nicola", "initials": "N"}, {"family": "Morales-Conde", "given": "Salvador", "initials": "S"}, {"family": "M\u00fcller-Stich", "given": "Beat P", "initials": "BP"}, {"family": "Nickel", "given": "Felix", "initials": "F"}, {"family": "Popa", "given": "Dorin", "initials": "D"}, {"family": "Tait", "given": "Diana", "initials": "D"}, {"family": "Thomas", "given": "Cenydd", "initials": "C"}, {"family": "Nimmo", "given": "Susan", "initials": "S"}, {"family": "Paraskevis", "given": "Dimitrios", "initials": "D"}, {"family": "Pietrabissa", "given": "Andrea", "initials": "A"}, {"family": "EAES Group of Experts for Recovery Amid COVID-19 Pandemic", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-10", "journal": {"title": "Surg Endosc", "issn": "1432-2218", "volume": null, "issue": null, "issn-l": null}, "abstract": "COVID-19 pandemic presented an unexpected challenge for the surgical community in general and Minimally Invasive Surgery (MIS) specialists in particular. This document aims to summarize recent evidence and experts' opinion and formulate recommendations to guide the surgical community on how to best organize the recovery plan for surgical activity across different sub-specialities after the COVID-19 pandemic.\n\nRecommendations were developed through a Delphi process for establishment of expert consensus. Domain topics were formulated and subsequently subdivided into questions pertinent to different surgical specialities following the COVID-19 crisis. Sixty-five experts from 24 countries, representing the entire EAES board, were invited. Fifty clinicians and six engineers accepted the invitation and drafted statements based on specific key questions. Anonymous voting on the statements was performed until consensus was achieved, defined by at least 70% agreement.\n\nA total of 92 consensus statements were formulated with regard to safe resumption of surgery across eight domains, addressing general surgery, upper GI, lower GI, bariatrics, endocrine, HPB, abdominal wall and technology/research. The statements addressed elective and emergency services across all subspecialties with specific attention to the role of MIS during the recovery plan. Eighty-four of the statements were approved during the first round of Delphi voting (91.3%) and another 8 during the following round after substantial modification, resulting in a 100% consensus.\n\nThe recommendations formulated by the EAES board establish a framework for resumption of surgery following COVID-19 pandemic with particular focus on the role of MIS across surgical specialities. The statements have the potential for wide application in the clinical setting, education activities and research work across different healthcare systems.", "doi": "10.1007/s00464-020-08131-0", "pmid": "33170335", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00464-020-08131-0"}, {"db": "pmc", "key": "PMC7653984"}], "notes": [], "created": "2020-11-30T16:30:45.726Z", "modified": "2020-11-30T16:30:45.750Z"}, {"entity": "publication", "iuid": "bb567e9f4e7a4b8c9a0463a6c345d634", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb567e9f4e7a4b8c9a0463a6c345d634.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb567e9f4e7a4b8c9a0463a6c345d634"}}, "title": "Prone positioning in mechanically ventilated patients with severe acute respiratory distress syndrome and coronavirus disease 2019.", "authors": [{"family": "Gleissman", "given": "Helena", "initials": "H"}, {"family": "Forsgren", "given": "Anders", "initials": "A"}, {"family": "Andersson", "given": "Elisabeth", "initials": "E"}, {"family": "Lindqvist", "given": "Elin", "initials": "E"}, {"family": "Lipka Falck", "given": "Adam", "initials": "A"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Dahlberg", "given": "Martin", "initials": "M"}, {"family": "G\u00fcnther", "given": "Mattias", "initials": "M"}], "type": "journal article", "published": "2020-11-09", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "volume": null, "issue": null, "issn-l": "0001-5172"}, "abstract": "The management of COVID-19 ARDS is debated. Although current evidence does not suggest an atypical acute respiratory distress syndrome (ARDS), the physiological response to prone positioning is not fully understood and it is unclear which patients benefit. We aimed to determine whether proning increases oxygenation and to evaluate responders.\n\nThis case series from a single, tertiary university hospital includes all mechanically ventilated patients with COVID-19 and proning between 17 March 2020 and 19 May 2020. The primary measure was change in PaO 2 :FiO2 .\n\nForty-four patients, 32 males/12 females, were treated with proning for a total of 138 sessions, with median (range) two (1-8) sessions. Median (IQR) time for the five sessions was 14 (12-17) hours. In the first session, median (IQR) PaO 2 :FiO2 increased from 104 (86-122) to 161 (127-207) mm Hg (P < .001). 36/44 patients (82%) improved in PaO2 :FiO2 , with a significant increase in PaO2 :FiO2 in the first three sessions. Median (IQR) FiO2 decreased from 0.7 (0.6-0.8) to 0.5 (0.35-0.6) (<0.001). A significant decrease occurred in the first three sessions. PaO2 , tidal volumes, PEEP, mean arterial pressure (MAP), and norepinephrine infusion did not differ. Primarily, patients with PaO2 :FiO2 approximately < 120 mm Hg before treatment responded to proning. Age, sex, BMI, or SAPS 3 did not predict success in increasing PaO2 :FiO2 .\n\nProning increased PaO 2 :FiO2 , primarily in patients with PaO2 :FiO2 approximately < 120 mm Hg, with a consistency over three sessions. No characteristic was associated with non-responding, why proning may be considered in most patients. Further study is required to evaluate mortality.", "doi": "10.1111/aas.13741", "pmid": "33165936", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-27T10:05:33.757Z", "modified": "2021-02-26T08:45:48.620Z"}, {"entity": "publication", "iuid": "fe33af25ffb64d688a4a3fb24a350de4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fe33af25ffb64d688a4a3fb24a350de4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fe33af25ffb64d688a4a3fb24a350de4"}}, "title": "COVID-19 during Pregnancy and Postpartum.", "authors": [{"family": "Naidu Ms PharmD", "given": "Sreus A G", "initials": "SAG"}, {"family": "Clemens DrPH Fift Cfs Fasn Facn Cns Fiafst", "given": "Roger A", "initials": "RA"}, {"family": "Pressman Md Ms Facn", "given": "Peter", "initials": "P"}, {"family": "Zaigham BSc Md PhD", "given": "Mehreen", "initials": "M"}, {"family": "Kadkhoda PhD Sm Ascp D Abmm D Abmli", "given": "Kamran", "initials": "K"}, {"family": "Davies PhD DSc Mae Frsc Frcp Fls Fri", "given": "Kelvin J A", "initials": "KJA"}, {"family": "Naidu PhD Facn Fls Fissvd", "given": "A Satyanarayan", "initials": "AS"}], "type": "journal article", "published": "2020-11-08", "journal": {"title": "J Diet Suppl", "issn": "1939-022X", "volume": null, "issue": null, "pages": "1-28", "issn-l": "1939-0211"}, "abstract": "Coronavirus Disease 2019 (COVID-19) triggered by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection has been declared a pandemic by the World Health Organization (WHO) on March 11, 2020. Oxidative stress and its related metabolic syndromes are potential risk factors in the susceptibility to, and severity of COVID-19. In concert with the earliest reports of COVID-19, obstetricians started to diagnose and treat SARS-CoV-2 infections during pregnancy (\"COVID-19-Pregnancy\"). High metabolic demand to sustain normal fetal development increases the burden of oxidative stress in pregnancy. Intracellular redox changes intertwined with acute phase responses at the maternal-fetal interface could amplify during pregnancy. Interestingly, mother-to-fetus transmission of SARS-CoV-2 has not been detected in most of the COVID-19-Pregnancy cases. This relative absence of vertical transmission may be related to the presence of lactoferrin in the placenta, amniotic fluid, and lacteal secretions. However, the cytokine-storm induced during COVID-19-Pregnancy may cause severe inflammatory damage to the fetus, and if uncontrolled, may later result in autism spectrum-like disorders and brain development abnormalities in neonates. Considering this serious health threat to child growth and development, the prevention of COVID-19 during pregnancy should be considered a high priority. This review summarizes the intricate virulence factors of COVID-19 and elucidate its pathobiological spectrum during pregnancy and postpartum periods with a focus on the putative and complex roles of endogenous and exogenous lactoferrin in conferring immunological advantage to the host.", "doi": "10.1080/19390211.2020.1834049", "pmid": "33164601", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-27T11:01:15.701Z", "modified": "2020-11-27T11:03:50.332Z"}, {"entity": "publication", "iuid": "e6ab3a8d7c344df9bb18ae2700312888", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6ab3a8d7c344df9bb18ae2700312888.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6ab3a8d7c344df9bb18ae2700312888"}}, "title": "How children and young people can stay physically active during the novel coronavirus pandemic while take into account safety measures and precautions.", "authors": [{"family": "Fr\u00f6berg", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2020-11-07", "journal": {"title": "Health Promot Perspect", "issn": "2228-6497", "volume": "10", "issue": "4", "pages": "295-299", "issn-l": null}, "abstract": "The novel coronavirus (COVID-19) outbreak has caused major public concern and posed challenges to societies across the globe. The COVID-19 pandemic might have implications for health-related behaviors, such as physical activity, among people in different age groups. Lately, a number of papers have offered suggestions and recommendations on how to stay physically active during the novel coronavirus pandemic while take into account safety measures and precautions. Many of these suggestions and recommendations might be relevant for health professionals and health practitioners working to facilitate physical activity, health, and well-being among children and young people. In light of the COVID-19pandemic, this paper provides an overview of (a) suggestions and recommendations on physical activities; and (b) safety measures and precautions while being physically active.", "doi": "10.34172/hpp.2020.47", "pmid": "33312924", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7722993"}], "notes": [], "created": "2020-12-21T10:18:32.884Z", "modified": "2021-02-26T08:47:00.269Z"}, {"entity": "publication", "iuid": "511d36d8ecdb449d868b55a96b910565", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/511d36d8ecdb449d868b55a96b910565.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/511d36d8ecdb449d868b55a96b910565"}}, "title": "Weak anti-SARS-CoV-2 antibody response is associated with mortality in a Swedish cohort of COVID-19 patients in critical care.", "authors": [{"family": "Asif", "given": "Sana", "initials": "S"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Kristensen", "given": "Bjarne", "initials": "B"}, {"family": "Alving", "given": "Kjell", "initials": "K"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}], "type": "journal article", "published": "2020-11-06", "journal": {"title": "Crit Care", "issn": "1466-609X", "issn-l": "1364-8535", "volume": "24", "issue": "1", "pages": "639"}, "abstract": null, "doi": "10.1186/s13054-020-03362-y", "pmid": "33158455", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-020-03362-y"}, {"db": "pmc", "key": "PMC7645408"}], "notes": [], "created": "2020-11-11T07:29:15.329Z", "modified": "2022-02-14T07:49:35.193Z"}, {"entity": "publication", "iuid": "42eac4db2cb44eb59410e1021db054ad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/42eac4db2cb44eb59410e1021db054ad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/42eac4db2cb44eb59410e1021db054ad"}}, "title": "Utility of Proteomics in Emerging and Re-Emerging Infectious Diseases Caused by RNA Viruses.", "authors": [{"family": "Sperk", "given": "Maike", "initials": "M"}, {"family": "van Domselaar", "given": "Robert", "initials": "R"}, {"family": "Rodriguez", "given": "Jimmy Esneider", "initials": "JE"}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "S\u00e1 Vinhas", "given": "Beatriz", "initials": "B"}, {"family": "Saccon", "given": "Elisa", "initials": "E"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Singh", "given": "Kamal", "initials": "K"}, {"family": "Gupta", "given": "Soham", "initials": "S"}, {"family": "V\u00e9gv\u00e1ri", "given": "\u00c1kos", "initials": "\u00c1"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "journal article", "published": "2020-11-06", "journal": {"title": "J Proteome Res", "issn": "1535-3907", "issn-l": null, "volume": "19", "issue": "11", "pages": "4259-4274"}, "abstract": "Emerging and re-emerging infectious diseases due to RNA viruses cause major negative consequences for the quality of life, public health, and overall economic development. Most of the RNA viruses causing illnesses in humans are of zoonotic origin. Zoonotic viruses can directly be transferred from animals to humans through adaptation, followed by human-to-human transmission, such as in human immunodeficiency virus (HIV), severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and, more recently, SARS coronavirus 2 (SARS-CoV-2), or they can be transferred through insects or vectors, as in the case of Crimean-Congo hemorrhagic fever virus (CCHFV), Zika virus (ZIKV), and dengue virus (DENV). At the present, there are no vaccines or antiviral compounds against most of these viruses. Because proteins possess a vast array of functions in all known biological systems, proteomics-based strategies can provide important insights into the investigation of disease pathogenesis and the identification of promising antiviral drug targets during an epidemic or pandemic. Mass spectrometry technology has provided the capacity required for the precise identification and the sensitive and high-throughput analysis of proteins on a large scale and has contributed greatly to unravelling key protein-protein interactions, discovering signaling networks, and understanding disease mechanisms. In this Review, we present an account of quantitative proteomics and its application in some prominent recent examples of emerging and re-emerging RNA virus diseases like HIV-1, CCHFV, ZIKV, and DENV, with more detail with respect to coronaviruses (MERS-CoV and SARS-CoV) as well as the recent SARS-CoV-2 pandemic.", "doi": "10.1021/acs.jproteome.0c00380", "pmid": "33095583", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7640957"}], "notes": [], "created": "2020-12-01T15:33:37.364Z", "modified": "2021-02-26T08:45:02.967Z"}, {"entity": "publication", "iuid": "7bb177f83a4e475e9037154ad9bdc8f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7bb177f83a4e475e9037154ad9bdc8f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7bb177f83a4e475e9037154ad9bdc8f1"}}, "title": "The Impact of COVID-19 on Criminal Investigations and Proceedings in Sweden - A Snapshot of Practitioners' Realities.", "authors": [{"family": "Lid\u00e9n", "given": "Moa", "initials": "M"}], "type": "journal article", "published": "2020-11-06", "journal": {"title": "Forensic Sci Int", "issn": "2589-871X", "issn-l": null, "volume": "2", "issue": null, "pages": "325-332"}, "abstract": "Since well-functioning criminal investigations and proceedings are crucial parts of a society governed by the rule of law, it is essential to understand whether and how they are impacted by the current COVID-19 pandemic. The Swedish context provides an interesting case study and comparison to developments in other countries which have introduced more far-reaching interventions such as lockdowns. In this study, Swedish practitioners (N =10), including police officers, forensic pathologists, prosecutors, defense counsels and judges, participated in an online survey in which they gave their views on the pandemic's impact on their work situations. The overall results show that the major impact was on their work methods, with transitions to using more online methods and increased remote working, while the smallest impact was noted in relation to work character, including crime and evidence types which have remained relatively constant. Forensic pathologists reported the largest impact on work quality, although there was large individual variation in their responses. On a general level, the practitioners perceived that the measures undertaken at their work places were relatively sufficient and also perceived of the risk of contracting or spreading the virus as relatively low but also this was associated with large individual variation. Given the small sample of practitioners and that practitioners' responses relate to an early stage of what is presumed to be a prolonged pandemic, replication as well as caution in interpreting the results are needed.", "doi": "10.1016/j.fsisyn.2020.11.001", "pmid": "33294832", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S2589-871X(20)30065-6"}, {"db": "pmc", "key": "PMC7689508"}], "notes": [], "created": "2020-12-13T07:20:58.444Z", "modified": "2022-11-09T08:25:07.841Z"}, {"entity": "publication", "iuid": "c493f63a0cbc43c396383a4cf1232f85", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c493f63a0cbc43c396383a4cf1232f85.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c493f63a0cbc43c396383a4cf1232f85"}}, "title": "Is It Just About Physical Health? An Online Cross-Sectional Study Exploring the Psychological Distress Among University Students in Jordan in the Midst of COVID-19 Pandemic.", "authors": [{"family": "Al-Tammemi", "given": "Ala'a B", "initials": "AB"}, {"family": "Akour", "given": "Amal", "initials": "A"}, {"family": "Alfalah", "given": "Laith", "initials": "L"}], "type": "journal article", "published": "2020-11-06", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "11", "issue": null, "pages": "562213"}, "abstract": "Since the spread of COVID-19 on a global scale, most of efforts at national and international levels were directed to mitigate the spread of the disease and its physical harm, paying less attention to the psychological impacts of COVID-19 on global mental health especially at early stages of the pandemic.\r\n\r\nThis study aimed to assess and explore (i) The levels of psychological distress and its correlates (ii) Motivation for distance learning (iii) Coping activities and pandemic related concerns, among university students in Jordan in the midst of COVID-19 pandemic.\r\n\r\nA cross-sectional study was conducted using an online self-administered questionnaire. The measure of psychological distress was obtained using the 10-item Kessler Psychological Distress Scale, while other questions have explored our study's second and third aims.\r\n\r\nA total of 381 completed questionnaires were included in the analysis. Female participants slightly predominated the sample ( n = 199, 52.2%). The respondents aged 18-38 years (mean 22.6 years, SD: 3.16). Concerning distress severity, most of respondents were regarded as having severe psychological distress (n = 265, 69.5%). 209 students (54.9%) reported that they had no motivation for distance learning. Ordinal logistic regression revealed a significant correlation between distress severity and many predictors. Among the predictors that were found to act as protective factors against higher levels of distress included older age (aOR = 0.64, P = 0.022; 95% CI: 0.44-0.94), and having a strong motivation for distance learning (aOR = 0.10, P = 0.048; 95% CI: 0.01-0.96). In contrary, being a current smoker (aOR = 1.99, P = 0.049; 95% CI: 1.10-3.39), and having no motivation for distance learning (aOR = 2.49, P = 0.007; 95% CI: 1.29-4.80) acted as risk factors for having higher levels of psychological distress among the students. The most common coping activity reported was spending more time on social media platforms (n = 269, 70.6%), and 209 students (54.9%) reported distance learning as their most distressing concern.\r\n\r\nThe COVID-19 pandemic and related control measures could impact the mental health of individuals, including students. We recommend a nationwide psychological support program to be incorporated into Jordan's preparedness plan and response strategy in combating the COVID-19 pandemic.", "doi": "10.3389/fpsyg.2020.562213", "pmid": "33240151", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-11-27T10:26:56.700Z", "modified": "2022-11-09T08:26:17.199Z"}, {"entity": "publication", "iuid": "f7f7b25eb9d046b4baf27e0470dc9510", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7f7b25eb9d046b4baf27e0470dc9510.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7f7b25eb9d046b4baf27e0470dc9510"}}, "title": "COVID-19: Nanomedicine Uncovers Blood-Clot Mystery.", "authors": [{"family": "Saei", "given": "Amir Ata", "initials": "AA"}, {"family": "Sharifi", "given": "Shahriar", "initials": "S"}, {"family": "Mahmoudi", "given": "Morteza", "initials": "M"}], "type": "journal article", "published": "2020-11-06", "journal": {"title": "J Proteome Res", "issn": "1535-3907", "volume": "19", "issue": "11", "pages": "4364-4373", "issn-l": null}, "abstract": "Further complications associated with infection by severe acute respiratory syndrome coronavirus 2 (a.k.a. SARS-CoV-2) continue to be reported. Very recent findings reveal that 20-30% of patients at high risk of mortality from COVID-19 infection experience blood clotting that leads to stroke and sudden death. Timely assessment of the severity of blood clotting will be of enormous help to clinicians in determining the right blood-thinning medications to prevent stroke or other life-threatening consequences. Therefore, rapid identification of blood-clotting-related proteins in the plasma of COVID-19 patients would save many lives. Several nanotechnology-based approaches are being developed to diagnose patients at high risk of death due to complications from COVID-19 infections, including blood clots. This Perspective outlines (i) the significant potential of nanomedicine in assessing the risk of blood clotting and its severity in SARS-CoV-2 infected patients and (ii) its synergistic roles with advanced mass-spectrometry-based proteomics approaches in identifying the important protein patterns that are involved in the occurrence and progression of this disease. The combination of such powerful tools might help us understand the clotting phenomenon and pave the way for development of new diagnostics and therapeutics in the fight against COVID-19.", "doi": "10.1021/acs.jproteome.0c00425", "pmid": "32790309", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7640964"}], "notes": [], "created": "2020-12-07T13:26:03.336Z", "modified": "2020-12-07T13:26:03.347Z"}, {"entity": "publication", "iuid": "facb78b4ec404e50a6986cb53cf8a3ec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/facb78b4ec404e50a6986cb53cf8a3ec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/facb78b4ec404e50a6986cb53cf8a3ec"}}, "title": "Searching for target-specific and multi-targeting organics for Covid-19 in the Drugbank database with a double scoring approach.", "authors": [{"family": "Murugan", "given": "Natarajan Arul", "initials": "NA"}, {"family": "Kumar", "given": "Sanjiv", "initials": "S"}, {"family": "Jeyakanthan", "given": "Jeyaraman", "initials": "J"}, {"family": "Srivastava", "given": "Vaibhav", "initials": "V"}], "type": "journal article", "published": "2020-11-05", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "10", "issue": "1", "pages": "19125"}, "abstract": "The current outbreak of Covid-19 infection due to SARS-CoV-2, a virus from the coronavirus family, has become a major threat to human healthcare. The virus has already infected more than 44 M people and the number of deaths reported has reached more than 1.1 M which may be attributed to lack of medicine. The traditional drug discovery approach involves many years of rigorous research and development and demands for a huge investment which cannot be adopted for the ongoing pandemic infection. Rather we need a swift and cost-effective approach to inhibit and control the viral infection. With the help of computational screening approaches and by choosing appropriate chemical space, it is possible to identify lead drug-like compounds for Covid-19. In this study, we have used the Drugbank database to screen compounds against the most important viral targets namely 3C-like protease (3CLpro), papain-like protease (PLpro), RNA-dependent RNA polymerase (RdRp) and the spike (S) protein. These targets play a major role in the replication/transcription and host cell recognition, therefore, are vital for the viral reproduction and spread of infection. As the structure based computational screening approaches are more reliable, we used the crystal structures for 3C-like main protease and spike protein. For the remaining targets, we used the structures based on homology modeling. Further, we employed two scoring methods based on binding free energies implemented in AutoDock Vina and molecular mechanics-generalized Born surface area approach. Based on these results, we propose drug cocktails active against the three viral targets namely 3CLpro, PLpro and RdRp. Interestingly, one of the identified compounds in this study i.e. Baloxavir marboxil has been under clinical trial for the treatment of Covid-19 infection. In addition, we have identified a few compounds such as Phthalocyanine, Tadalafil, Lonafarnib, Nilotinib, Dihydroergotamine, R-428 which can bind to all three targets simultaneously and can serve as multi-targeting drugs. Our study also included calculation of binding energies for various compounds currently under drug trials. Among these compounds, it is found that Remdesivir binds to targets, 3CLpro and RdRp with high binding affinity. Moreover, Baricitinib and Umifenovir were found to have superior target-specific binding while Darunavir is found to be a potential multi-targeting drug. As far as we know this is the first study where the compounds from the Drugbank database are screened against four vital targets of SARS-CoV-2 and illustrates that the computational screening using a double scoring approach can yield potential drug-like compounds against Covid-19 infection.", "doi": "10.1038/s41598-020-75762-7", "pmid": "33154404", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-020-75762-7"}, {"db": "pmc", "key": "PMC7645721"}], "notes": [], "created": "2020-12-01T14:46:02.174Z", "modified": "2021-02-26T08:45:25.943Z"}, {"entity": "publication", "iuid": "751306da9bde4244b9913b6fd059cf8d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/751306da9bde4244b9913b6fd059cf8d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/751306da9bde4244b9913b6fd059cf8d"}}, "title": "Hospital preparedness challenges in biological disasters: A qualitative study.", "authors": [{"family": "Aminizadeh", "given": "Mohsen", "initials": "M"}, {"family": "Farrokhi", "given": "Mehrdad", "initials": "M"}, {"family": "Ebadi", "given": "Abbas", "initials": "A"}, {"family": "Masoumi", "given": "Gholam Reza", "initials": "GR"}, {"family": "Kolivand", "given": "Pirhossein", "initials": "P"}, {"family": "Khankeh", "given": "Hamid Reza", "initials": "HR"}], "type": "journal article", "published": "2020-11-05", "journal": {"title": "Disaster Med Public Health Prep", "issn": "1938-744X", "issn-l": "1935-7893", "volume": null, "issue": null, "pages": "1-13"}, "abstract": "Identification of hospital preparedness challenges against biological events such as COVID-19 is essential to improve dynamics, quality and business continuity confidence in the health system. Accordingly, the purpose of the present study is to evaluate the challenges of hospital preparedness in biological events.\r\n\r\nThis study employed a qualitative method using content analysis in which 20 healthcare managers and experts who are experienced in biological events were selected through purposeful sampling. The data collection was done through semi-structured interviews, which continued until data saturation. The data were analyzed using qualitative content analysis as well as the Landman and Graneheim Approach.\r\n\r\nSix main concepts (training and practice, resource management, safety and health, patient management, risk communication, and laboratory and surveillance) and 14 sub-concepts were extracted on hospital preparedness challenges in biological events through analyzing interviews.\r\n\r\nThe present study indicated that the health system of the country faces many challenges in response to biological events and threats. Moreover, study participants indicated that Iranian hospitals were not prepared for biological events. It is recommended to design preparedness plans of hospitals based on preparedness standards for biological events. In addition, comprehensive measures are required to enhance their capacity to respond to biological emergencies.", "doi": "10.1017/dmp.2020.434", "pmid": "33148363", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1935789320004346"}], "notes": [], "created": "2020-11-27T10:13:26.533Z", "modified": "2022-11-09T08:27:25.836Z"}, {"entity": "publication", "iuid": "d5b3f3d7bcd049fea392cd3db33852a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5b3f3d7bcd049fea392cd3db33852a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5b3f3d7bcd049fea392cd3db33852a2"}}, "title": "Effect and safety of Chinese herbal medicine granules in patients with severe coronavirus disease 2019 in Wuhan, China: a retrospective, single-center study with propensity score matching.", "authors": [{"family": "Wang", "given": "Yuanyuan", "initials": "Y"}, {"family": "Liu", "given": "Yuntao", "initials": "Y"}, {"family": "Lv", "given": "Qingquan", "initials": "Q"}, {"family": "Zheng", "given": "Danwen", "initials": "D"}, {"family": "Zhou", "given": "Li", "initials": "L"}, {"family": "Ouyang", "given": "Wenwei", "initials": "W"}, {"family": "Ding", "given": "Banghan", "initials": "B"}, {"family": "Zou", "given": "Xu", "initials": "X"}, {"family": "Yan", "given": "Fang", "initials": "F"}, {"family": "Liu", "given": "Bo", "initials": "B"}, {"family": "Chen", "given": "Jun", "initials": "J"}, {"family": "Liu", "given": "Tianzhu", "initials": "T"}, {"family": "Fu", "given": "Chicheng", "initials": "C"}, {"family": "Fang", "given": "Qu", "initials": "Q"}, {"family": "Wang", "given": "Yi", "initials": "Y"}, {"family": "Li", "given": "Fang", "initials": "F"}, {"family": "Chen", "given": "Ailan", "initials": "A"}, {"family": "Lundborg", "given": "Cecilia St\u00e5lsby", "initials": "CS"}, {"family": "Guo", "given": "Jianwen", "initials": "J"}, {"family": "Wen", "given": "Zehuai", "initials": "Z"}, {"family": "Zhang", "given": "Zhongde", "initials": "Z"}], "type": "journal article", "published": "2020-11-05", "journal": {"title": "Phytomedicine", "issn": "1618-095X", "volume": null, "issue": null, "pages": "153404", "issn-l": "0944-7113"}, "abstract": "Chinese herbal medicine (CHM) has been used for severe illness caused by coronavirus disease 2019 (COVID-19), but its treatment effects and safety are unclear.\n\nThis study reviews the effect and safety of CHM granules in the treatment of patients with severe COVID-19.\n\nWe conducteda single-center, retrospective study on patients with severe COVID-19 in a designated hospital in Wuhan from January 15, 2020 to March 30, 2020. The propensity score matching (PSM) was used to assess the effect and safety of the treatment using CHM granules. The ratio of patients who received treatment with CHM granules combined with usual care and those who received usual care alone was 1:1. The primary outcome was the time to clinical improvement within 28 days, defined as the time taken for the patients' health to show improvement by decline of two categories (from the baseline) on a modified six-category ordinal scale, or to be dischargedfrom the hospital before Day 28.\n\nUsing PSM, 43 patients (45% male) aged 65.6 (57-70) yearsfrom each group were exactly matched. No significant difference was observed in clinical improvement of patients treated with CHM granules compared with those who received usual (p = 0.851). However, the use of CHM granules reduced the 28-day mortality (p = 0.049) and shortened the duration of fever (4 days vs. 7 days, p = 0.002). The differences in the duration of cough and dyspnea and the difference in lung lesion ratio on computerized tomography scans were not significant.Commonly,patients in the CHM group had an increased D-dimer level (p = 0.036).\n\nForpatients with severe COVID-19, CHM granules, combined with usual care, showed no improvement beyond usual care alone. However, the use of CHM granules reduced the 28-day mortality rate and the time to fever alleviation. Nevertheless, CHM granules may be associated with high risk of fibrinolysis.", "doi": "10.1016/j.phymed.2020.153404", "pmid": "33637412", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0944-7113(20)30235-X"}], "notes": [], "created": "2021-03-01T10:28:51.462Z", "modified": "2021-03-01T10:28:51.473Z"}, {"entity": "publication", "iuid": "cd7cc72539de42339a8adea9f3ffbed2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd7cc72539de42339a8adea9f3ffbed2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd7cc72539de42339a8adea9f3ffbed2"}}, "title": "Differences of SARS-CoV-2 serological test performance between hospitalized and outpatient COVID-19 cases.", "authors": [{"family": "Wolf", "given": "Johannes", "initials": "J"}, {"family": "Kaiser", "given": "Thorsten", "initials": "T"}, {"family": "Pehnke", "given": "Sarah", "initials": "S"}, {"family": "Nickel", "given": "Olaf", "initials": "O"}, {"family": "L\u00fcbbert", "given": "Christoph", "initials": "C"}, {"family": "Kalbitz", "given": "Sven", "initials": "S"}, {"family": "Arnold", "given": "Benjamin", "initials": "B"}, {"family": "Ermisch", "given": "J\u00f6rg", "initials": "J"}, {"family": "Berger", "given": "Luisa", "initials": "L"}, {"family": "Schroth", "given": "Stefanie", "initials": "S"}, {"family": "Isermann", "given": "Berend", "initials": "B"}, {"family": "Borte", "given": "Stephan", "initials": "S"}, {"family": "Biemann", "given": "Ronald", "initials": "R"}], "type": "journal article", "published": "2020-11-05", "journal": {"title": "Clin Chim Acta", "issn": "1873-3492", "volume": null, "issue": null, "issn-l": "0009-8981"}, "abstract": "Serological severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody assays differ in the target antigen specificity, e.g. of antibodies directed against the viral spike or the nucleocapsid protein, and in the spectrum of detected immunoglobulins. The aim of the study was to evaluate the performance of two different routinely used immunoassays in hospitalized and outpatient COVID-19 cases.\n\nThe test characteristics of commercially available spike1 protein-based serological assays (Euroimmun, EI-assays), determining IgA or IgG and nucleocapsid-based assays (Virotech, VT-assays) determining IgA, IgM or IgG were compared in 139 controls and 116 hospitalized and outpatient COVID-19 cases.\n\nHospitalized COVID-19 patients (n = 51; 115 samples) showed significantly higher concentrations of antibodies against SARS-CoV-2 and differed from outpatient cases (n = 65) by higher age, higher disease severity scores and earlier follow up blood sampling. Sensitivity of the two IgG assays was comparable in hospitalized patients tested \u2265 14 days (EI-assay: 88%, CI 95% 67.6-99.9; VT-assay: 96%, CI95% 77.7-99.8). In outpatient COVID-19 cases sensitivity was significantly lower in the VT-assay (86.2%, CI95% 74.8-93.1) compared with the EI-assay (98.5%, CI95% 90.6-99.9). Assays for IgA and IgM demonstrated a lack of specificity or sensitivity.\n\nOur results indicate that SARS-CoV-2 serological assays may need to be optimized to produce reliable results in outpatient COVID-19 cases who are low or even asymptomatic. Assays for IgA and IgM have limited diagnostic performance and do not prove an additional value for population-based screening approaches.", "doi": "10.1016/j.cca.2020.10.035", "pmid": "33159952", "labels": {"Type: Journal article": null, "Category: Serology": null}, "xrefs": [{"db": "pii", "key": "S0009-8981(20)30517-9"}, {"db": "pmc", "key": "PMC7642750"}], "notes": [], "created": "2020-11-27T10:07:09.483Z", "modified": "2021-02-26T08:46:49.385Z"}, {"entity": "publication", "iuid": "0415d3631d304d8fbf5b049b0b57dc4f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0415d3631d304d8fbf5b049b0b57dc4f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0415d3631d304d8fbf5b049b0b57dc4f"}}, "title": "Changes in Tinnitus Experiences During the COVID-19 Pandemic.", "authors": [{"family": "Beukes", "given": "Eldr\u00e9 W", "initials": "EW"}, {"family": "Baguley", "given": "David M", "initials": "DM"}, {"family": "Jacquemin", "given": "Laure", "initials": "L"}, {"family": "Lourenco", "given": "Matheus P C G", "initials": "MPCG"}, {"family": "Allen", "given": "Peter M", "initials": "PM"}, {"family": "Onozuka", "given": "Joy", "initials": "J"}, {"family": "Stockdale", "given": "David", "initials": "D"}, {"family": "Kaldo", "given": "Viktor", "initials": "V"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Manchaiah", "given": "Vinaya", "initials": "V"}], "type": "journal article", "published": "2020-11-05", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "592878", "issn-l": "2296-2565"}, "abstract": "Introduction: The COVID-19 pandemic has disrupted delivery of healthcare, economic activity, and affected social interactions. Identifying and supporting those most affected by the pandemic is required. The purpose of this study was to determine the impact of the pandemic on individuals with tinnitus and to identify mediating factors. Methods: This is a mixed-methods exploratory cross-sectional study, using data collected via an online survey from 3,103 individuals with tinnitus from 48 countries. The greatest representation was from North America (49%) and Europe (47%) and other countries were only marginally represented. Results: Although the study was aimed at those with pre-existing tinnitus, 7 individuals reported having COVID-19 initiated tinnitus. Having COVID-19 symptoms exacerbated tinnitus in 40% of respondents, made no change in 54%, and improved tinnitus in 6%. Other mediating factors such as the social and emotional consequences of the pandemic made pre-existing tinnitus more bothersome for 32% of the respondents, particularly for females and younger adults, better for 1%, and caused no change to tinnitus for 67%. Pre-existing tinnitus was significantly exacerbated for those self-isolating, experiencing loneliness, sleeping poorly, and with reduced levels of exercise. Increased depression, anxiety, irritability, and financial worries further significantly contributed to tinnitus being more bothersome during the pandemic period. Conclusions: These findings have implications for tinnitus management, because they highlight the diverse response both internal and external factors have on tinnitus levels. Clinical services should be mindful that tinnitus may be caused by contracting COVID-19 and pre-existing tinnitus may be exacerbated, although in the majority of respondents there was no change. Additional support should be offered where tinnitus severity has increased due to the health, social, and/or emotional effects of the COVID-19 pandemic. Tinnitus may be more bothersome for those experiencing loneliness, having fewer social interactions, and who are more anxious or worried.", "doi": "10.3389/fpubh.2020.592878", "pmid": "33251179", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7676491"}], "notes": [], "created": "2020-12-03T08:25:37.374Z", "modified": "2021-02-26T08:45:47.798Z"}, {"entity": "publication", "iuid": "8b254ae76f9b47aabd6eea4864698cc3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b254ae76f9b47aabd6eea4864698cc3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b254ae76f9b47aabd6eea4864698cc3"}}, "title": "COVID-19 and misinformation: Is censorship of social media a remedy to the spread of medical misinformation?", "authors": [{"family": "Niemiec", "given": "Emilia", "initials": "E"}], "type": "journal article", "published": "2020-11-05", "journal": {"title": "EMBO Rep", "issn": "1469-3178", "volume": "21", "issue": "11", "pages": "e51420", "issn-l": null}, "abstract": "Social media companies have resorted to censorship to suppress misinformation about the COVID-19 pandemic. This is not the most prudent solution though given the uncertainties about the disease.", "doi": "10.15252/embr.202051420", "pmid": "33103289", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7645258"}], "notes": [], "created": "2020-12-01T15:26:00.457Z", "modified": "2020-12-01T15:26:15.906Z"}, {"entity": "publication", "iuid": "2caee507b4b1417aaf5e5dde8f795031", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2caee507b4b1417aaf5e5dde8f795031.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2caee507b4b1417aaf5e5dde8f795031"}}, "title": "The impact of the early phase of the COVID-19 pandemic on mental-health services in Europe.", "authors": [{"family": "Thome", "given": "Johannes", "initials": "J"}, {"family": "Deloyer", "given": "Jocelyn", "initials": "J"}, {"family": "Coogan", "given": "Andrew N", "initials": "AN"}, {"family": "Bailey-Rodriguez", "given": "Deborah", "initials": "D"}, {"family": "da Cruz E Silva", "given": "Odete A B", "initials": "OAB"}, {"family": "Faltraco", "given": "Frank", "initials": "F"}, {"family": "Grima", "given": "Cathleen", "initials": "C"}, {"family": "Gudjonsson", "given": "Snaebjorn Omar", "initials": "SO"}, {"family": "Hanon", "given": "Cecile", "initials": "C"}, {"family": "Holl\u00fd", "given": "Martin", "initials": "M"}, {"family": "Joosten", "given": "Jo", "initials": "J"}, {"family": "Karlsson", "given": "Ingegerd", "initials": "I"}, {"family": "Kelemen", "given": "Gabriela", "initials": "G"}, {"family": "Korman", "given": "Maria", "initials": "M"}, {"family": "Krysta", "given": "Krzysztof", "initials": "K"}, {"family": "Lichterman", "given": "Boleslav", "initials": "B"}, {"family": "Loganovsky", "given": "Konstantin", "initials": "K"}, {"family": "Marazziti", "given": "Donatella", "initials": "D"}, {"family": "Maraitou", "given": "Margarita", "initials": "M"}, {"family": "Mertens de Wilmars", "given": "Serge", "initials": "S"}, {"family": "Reunamen", "given": "Merja", "initials": "M"}, {"family": "Rexhaj", "given": "Shyhrete", "initials": "S"}, {"family": "Sancaktar", "given": "Muhammet", "initials": "M"}, {"family": "Sempere", "given": "Javier", "initials": "J"}, {"family": "Tournier", "given": "Isabelle", "initials": "I"}, {"family": "Weynant", "given": "Emilie", "initials": "E"}, {"family": "Vis", "given": "Christiaan", "initials": "C"}, {"family": "Lebas", "given": "Marie-Clotilde", "initials": "MC"}, {"family": "Fond-Harmant", "given": "Laurence", "initials": "L"}], "type": "journal article", "published": "2020-11-04", "journal": {"title": "World J Biol Psychiatry", "issn": "1814-1412", "volume": null, "issue": null, "pages": "1-15", "issn-l": null}, "abstract": "The current COVID-19 pandemic confronts psychiatric patients and mental health services with unique and severe challenges. In order to identify these trans-national challenges across Europe, an ad-hoc survey was conducted among 23 experts, each answering for one European or aligned country. A number of important themes and issues were raised for the impact of COVID-19 on mental health and mental health services, barriers to service provision and future consequences. A number of key issues were reported by colleagues across several jurisdictions, even though these were at different stages of their national epidemics. Based on these findings, we articulate some important learnings from the early stages of the COVID-19 European pandemic, and highlight key considerations for all countries' mental health services as the current pandemic develops and for future pandemics.", "doi": "10.1080/15622975.2020.1844290", "pmid": "33143529", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-01T14:50:54.093Z", "modified": "2020-12-01T14:50:54.114Z"}, {"entity": "publication", "iuid": "708edd457cd5407da90e7a672b55b849", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/708edd457cd5407da90e7a672b55b849.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/708edd457cd5407da90e7a672b55b849"}}, "title": "Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2", "authors": [{"family": "Cust\u00f3dio", "given": "T\u00e2nia F", "initials": "TF"}, {"family": "Das", "given": "Hrishikesh", "initials": "H"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Pazicky", "given": "Samuel", "initials": "S"}, {"family": "Pieprzyk", "given": "Joanna", "initials": "J"}, {"family": "Sorgenfrei", "given": "Mich\u00e8le", "initials": "M"}, {"family": "Schroer", "given": "Martin A", "initials": "MA"}, {"family": "Gruzinov", "given": "Andrey Yu", "initials": "AY"}, {"family": "Jeffries", "given": "Cy M", "initials": "CM"}, {"family": "Graewert", "given": "Melissa A", "initials": "MA"}, {"family": "Svergun", "given": "Dmitri I", "initials": "DI"}, {"family": "Dobrev", "given": "Nikolay", "initials": "N"}, {"family": "Remans", "given": "Kim", "initials": "K"}, {"family": "Seeger", "given": "Markus A", "initials": "MA"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "H\u00e4llberg", "given": "B Martin", "initials": "BM"}, {"family": "L\u00f6w", "given": "Christian", "initials": "C"}], "type": "journal-article", "published": "2020-11-04", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "11", "issue": "1", "pages": null}, "abstract": "The coronavirus SARS-CoV-2 is the cause of the ongoing COVID-19 pandemic. Therapeutic neutralizing antibodies constitute a key short-to-medium term approach to tackle COVID-19. However, traditional antibody production is hampered by long development times and costly production. Here, we report the rapid isolation and characterization of nanobodies from a synthetic library, known as sybodies (Sb), that target the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein. Several binders with low nanomolar affinities and efficient neutralization activity were identified of which Sb23 displayed high affinity and neutralized pseudovirus with an IC50 of 0.6\u2009\u00b5g/ml. A cryo-EM structure of the spike bound to Sb23 showed that Sb23 binds competitively in the ACE2 binding site. Furthermore, the cryo-EM reconstruction revealed an unusual conformation of the spike where two RBDs are in the \u2018up\u2019 ACE2-binding conformation. The combined approach represents an alternative, fast workflow to select binders with neutralizing activity against newly emerging viruses.", "doi": "10.1038/s41467-020-19204-y", "pmid": "33149112", "labels": {"Type: Journal article": null, "Funder: VR": null, "Research Area: Host cell systems biology and targets": null, "Funder: H2020": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Category: Other": null, "Category: Proteins": null}, "xrefs": [{"db": "URL", "key": "https://github.com/tania-custodio/Sb23", "description": "Github: MST and BLI data"}, {"db": "URL", "key": "https://www.sasbdb.org/data/SASDJF4/", "description": "SASBDB SASDJF4: Synthetic nanobody Sybody 23 (Sy23)"}, {"db": "URL", "key": "https://www.sasbdb.org/data/SASDJG4/", "description": "SASBDB SASDJG4: SARS-CoV-2 spike protein ACE2 receptor binding domain (RBD)"}, {"db": "URL", "key": "https://www.sasbdb.org/data/SASDJH4/", "description": "SASBDB SASDJH4: SARS-CoV-2 spike protein ACE2 receptor binding domain (RBD) bound to the synthetic nanobody Sybody 23 (Sy23)"}, {"db": "PDB", "key": "7A25", "description": "Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing sybodies (Sb23) (1-up)"}, {"db": "PDB", "key": "7A29", "description": "Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing sybodies (Sb23) (2-up)"}, {"db": "URL", "key": "https://www.ebi.ac.uk/pdbe/entry/emdb/EMD-11617", "description": "EMDB EMD-11617: Cryo-EM density maps of SARS-CoV-2 spike glycoprotein with Sb23 bound (2-up)"}, {"db": "URL", "key": "https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-020-19204-y/MediaObjects/41467_2020_19204_MOESM4_ESM.pdf", "description": "Sequences of all the selected sybodies from the study"}], "notes": [], "created": "2020-11-10T10:40:14.648Z", "modified": "2021-06-13T14:17:49.316Z"}, {"entity": "publication", "iuid": "ab683807584e43508e269e9580f7d3ac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ab683807584e43508e269e9580f7d3ac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ab683807584e43508e269e9580f7d3ac"}}, "title": "Innate lymphoid cell composition associates with COVID-19 disease severity", "authors": [{"family": "Garc\u00eda", "given": "Marina", "initials": "M"}, {"family": "Kokkinou", "given": "Efthymia", "initials": "E"}, {"family": "Carrasco Garc\u00eda", "given": "Anna", "initials": "A"}, {"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Palma Medina", "given": "Laura M.", "initials": "LM"}, {"family": "Maleki", "given": "Kimia T.", "initials": "KT"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Varnait\u0117", "given": "Renata", "initials": "R"}, {"family": "Filipovic", "given": "Iva", "initials": "I"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K.", "initials": "NK"}, {"family": "Folkesson", "given": "Elin", "initials": "E"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Eriksson", "given": "Lars I.", "initials": "LI"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J"}, {"family": "Group", "given": "the Karolinska KI/K COVID-19 Study", "initials": "tKKCS"}], "type": "posted-content", "published": "2020-11-04", "journal": {"title": "Clin Transl Immunol", "issn": "2050-0068", "issn-l": null, "volume": "9", "issue": "12", "pages": null}, "abstract": "Objectives The role of innate lymphoid cells (ILCs) in coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is unknown. Understanding the immune response in COVID-19 could contribute to unravel the pathogenesis and identification of treatment targets. To describe the phenotypic landscape of circulating ILCs in COVID-19 patients and to identify ILC phenotypes correlated to serum biomarkers, clinical markers, and laboratory parameters relevant in COVID-19.\r\n\r\nMethods Blood samples collected from moderately (n=11) and severely ill (n=12) COVID-19 patients as well as healthy control donors (n=16), were analyzed with 18-parameter flow cytometry. Using supervised and unsupervised approaches, we examined the ILC activation status and homing profile. Clinical and laboratory parameters were obtained from all COVID-19 patients and serum biomarkers were analyzed with multiplex immunoassays.\r\n\r\nResults ILCs were largely depleted from the circulation of COVID-19 patients compared with healthy controls. Remaining circulating ILCs from patients revealed increased frequencies of ILC2 in moderate COVID-19, with a concomitant decrease of ILC precursors (ILCp), as compared with controls. ILC2 and ILCp showed an activated phenotype with increased CD69 expression, whereas expression levels of the chemokine receptors CXCR3 and CCR4 were significantly altered in ILC2 and ILCp, and ILC1, respectively. The activated ILC profile of COVID-19 patients was associated with soluble inflammatory markers, while frequencies of ILC subsets were correlated with laboratory parameters that reflect the disease severity.\r\n\r\nConclusion This study provides insights into the potential role of ILCs in immune responses against SARS-CoV-2, particularly linked to the severity of COVID-19.", "doi": "10.1002/cti2.1224", "pmid": "33343897", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://covid19cellatlas.com/#/", "description": "Karolinska KI/K Covid19 Immune atlas"}], "notes": [], "created": "2020-11-04T14:24:06.108Z", "modified": "2021-06-13T14:18:39.784Z"}, {"entity": "publication", "iuid": "2ba162b83ed44bdcb5738acf41b3156e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ba162b83ed44bdcb5738acf41b3156e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ba162b83ed44bdcb5738acf41b3156e"}}, "title": "Global between-countries variance in SARS-CoV-2 mortality is driven by reported prevalence, age distribution, and case detection rate", "authors": [{"family": "Baba\u010di\u0107", "given": "Haris", "initials": "H"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J"}, {"family": "Pernemalm", "given": "Maria", "initials": "M"}], "type": null, "published": "2020-11-04", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Objective: To explain the global between-countries variance in number of deaths per million citizens (nDpm) and case fatality rate (CFR) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Design: Systematic analysis. Data sources: Worldometer, European Centre for Disease Prevention and Control, United Nations Main outcome measures: The explanators of nDpm and CFR were mathematically hypothesised and tested on publicly-available data from 88 countries with linear regression models on May 1st 2020. The derived explanators - age-adjusted infection fatality rate (IFRadj) and case detection rate (CDR) - were estimated for each country based on a SARS-CoV-2 model of China. The accuracy and agreement of the models with observed data was assessed with R2 and Bland-Altman plots, respectively. Sensitivity analyses involved removal of outliers and testing the models at five retrospective and two prospective time points. Results: Globally, IFRadj estimates varied between countries, ranging from below 0.2% in the youngest nations, to above 1.3% in Portugal, Greece, Italy, and Japan. The median estimated global CDR of SARS-CoV-2 infections on April 16th 2020 was 12.9%, suggesting that most of the countries have a much higher number of cases than reported. At least 93% and up to 99% of the variance in nDpm was explained by reported prevalence expressed as cases per million citizens (nCpm), IFRadj, and CDR. IFRadj and CDR accounted for up to 97% of the variance in CFR, but this model was less reliable than the nDpm model, being sensitive to outliers (R2 as low as 67.5%). Conclusions: The current differences in SARS-CoV-2 mortality between countries are driven mainly by reported prevalence of infections, age distribution, and CDR. The nDpm might be a more stable estimate than CFR in comparing mortality burden between countries.", "doi": "10.1101/2020.05.28.20114934", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-04T15:42:54.004Z", "modified": "2021-02-26T08:45:47.974Z"}, {"entity": "publication", "iuid": "7a93d531baf34f3cbe335fcb17e935f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a93d531baf34f3cbe335fcb17e935f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a93d531baf34f3cbe335fcb17e935f8"}}, "title": "Circulating bioactive adrenomedullin as a marker of sepsis, septic shock and critical illness.", "authors": [{"family": "Lundberg", "given": "Oscar H M", "initials": "OHM"}, {"family": "Lengquist", "given": "Maria", "initials": "M"}, {"family": "Sp\u00e5ngfors", "given": "Martin", "initials": "M"}, {"family": "Annborn", "given": "Martin", "initials": "M"}, {"family": "Bergmann", "given": "Deborah", "initials": "D"}, {"family": "Schulte", "given": "Janin", "initials": "J"}, {"family": "Levin", "given": "Helena", "initials": "H"}, {"family": "Melander", "given": "Olle", "initials": "O"}, {"family": "Frigyesi", "given": "Attila", "initials": "A"}, {"family": "Friberg", "given": "Hans", "initials": "H"}], "type": "journal article", "published": "2020-11-04", "journal": {"title": "Crit Care", "issn": "1466-609X", "volume": "24", "issue": "1", "pages": "636", "issn-l": "1364-8535"}, "abstract": "Biomarkers can be of help to understand critical illness and to identify and stratify sepsis. Adrenomedullin is a vasoactive hormone, with reported prognostic and potentially therapeutic value in sepsis. The primary aim of this study was to investigate the association of circulating bioactive adrenomedullin (bio-ADM) levels at intensive care unit (ICU) admission with mortality in sepsis patients and in a general ICU population. Secondary aims included the association of bio-ADM with organ failure and the ability of bio-ADM to identify sepsis.\n\nIn this retrospective observational study, adult patients admitted to one of four ICUs during 2016 had admission bio-ADM levels analysed. Age-adjusted odds ratios (OR) with 95% CI for log-2 transformed bio-ADM, and Youden's index derived cut-offs were calculated. The primary outcome was 30-day mortality, and secondary outcomes included the need for organ support and the ability to identify sepsis.\n\nBio-ADM in 1867 consecutive patients were analysed; 632 patients fulfilled the sepsis-3 criteria of whom 267 had septic shock. The median bio-ADM in the entire ICU population was 40 pg/mL, 74 pg/mL in sepsis patients, 107 pg/mL in septic shock and 29 pg/mL in non-septic patients. The association of elevated bio-ADM and mortality in sepsis patients and the ICU population resulted in ORs of 1.23 (95% CI 1.07-1.41) and 1.22 (95% CI 1.12-1.32), respectively. The association with mortality remained after additional adjustment for lactate in sepsis patients. Elevated bio-ADM was associated with an increased need for dialysis with ORs of 2.28 (95% CI 2.01-2.59) and 1.97 (95% CI 1.64-2.36) for the ICU population and sepsis patients, respectively, and with increased need of vasopressors, OR 1.33 (95% CI 1.23-1.42) (95% CI 1.17-1.50) for both populations. Sepsis was identified with an OR of 1.78 (95% CI 1.64-1.94) for bio-ADM, after additional adjustment for severity of disease. A bio-ADM cut-off of 70 pg/mL differentiated between survivors and non-survivors in sepsis, but a Youden's index derived threshold of 108 pg/mL performed better.\n\nAdmission bio-ADM is associated with 30-day mortality and organ failure in sepsis patients as well as in a general ICU population. Bio-ADM may be a morbidity-independent sepsis biomarker.", "doi": "10.1186/s13054-020-03351-1", "pmid": "33148300", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7641835"}, {"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-12-02T18:20:01.327Z", "modified": "2021-02-26T08:45:48.358Z"}, {"entity": "publication", "iuid": "8cc0ac83572f4f3a9281eda66d0746a5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8cc0ac83572f4f3a9281eda66d0746a5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8cc0ac83572f4f3a9281eda66d0746a5"}}, "title": "Associations between mortality from COVID-19 in two Italian regions and outdoor air pollution as assessed through tropospheric nitrogen dioxide.", "authors": [{"family": "Filippini", "given": "Tommaso", "initials": "T"}, {"family": "Rothman", "given": "Kenneth J", "initials": "KJ"}, {"family": "Cocchio", "given": "Silvia", "initials": "S"}, {"family": "Narne", "given": "Elena", "initials": "E"}, {"family": "Mantoan", "given": "Domenico", "initials": "D"}, {"family": "Saia", "given": "Mario", "initials": "M"}, {"family": "Goffi", "given": "Alessia", "initials": "A"}, {"family": "Ferrari", "given": "Fabrizio", "initials": "F"}, {"family": "Maffeis", "given": "Giuseppe", "initials": "G"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}, {"family": "Baldo", "given": "Vincenzo", "initials": "V"}, {"family": "Vinceti", "given": "Marco", "initials": "M"}], "type": "journal article", "published": "2020-11-04", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "volume": "760", "issue": null, "pages": "143355", "issn-l": "0048-9697"}, "abstract": "After the appearance of COVID-19 in China last December 2019, Italy was the first European country to be severely affected by the outbreak. The first diagnosis in Italy was on February 20, 2020, followed by the establishment of a light and a tight lockdown on February 23 and on March 8, 2020, respectively. The virus spread rapidly, particularly in the North of the country in the 'Padan Plain' area, known as one of the most polluted regions in Europe. Air pollution has been recently hypothesized to enhance the clinical severity of SARS-CoV-2 infection, acting through adverse effects on immunity, induction of respiratory and other chronic disease, upregulation of viral receptor ACE-2, and possible pathogen transportation as a virus carrier. We investigated the association between air pollution and subsequent COVID-19 mortality rates within two Italian regions (Veneto and Emilia-Romagna). We estimated ground-level nitrogen dioxide through its tropospheric levels using data available from the Sentinel-5P satellites of the European Space Agency Copernicus Earth Observation Programme before the lockdown. We then examined COVID-19 mortality rates in relation to the nitrogen dioxide levels at three 14-day lag points after the lockdown, namely March 8, 22 and April 5, 2020. Using a multivariable negative binomial regression model, we found an association between nitrogen dioxide and COVID-19 mortality. Although ecological data provide only weak evidence, these findings indicate an association between air pollution levels and COVID-19 severity.", "doi": "10.1016/j.scitotenv.2020.143355", "pmid": "33187703", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(20)36886-8"}, {"db": "pmc", "key": "PMC7609227"}], "notes": [], "created": "2020-11-27T09:58:18.493Z", "modified": "2021-02-26T08:46:13.371Z"}, {"entity": "publication", "iuid": "16e615de9a304cc385f80806c47bc1fe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16e615de9a304cc385f80806c47bc1fe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16e615de9a304cc385f80806c47bc1fe"}}, "title": "Decision-making around admission to intensive care in the UK pre-COVID-19: a multicentre ethnographic study.", "authors": [{"family": "Griffiths", "given": "F", "initials": "F"}, {"family": "Svantesson", "given": "M", "initials": "M"}, {"family": "Bassford", "given": "C", "initials": "C"}, {"family": "Dale", "given": "J", "initials": "J"}, {"family": "Blake", "given": "C", "initials": "C"}, {"family": "McCreedy", "given": "A", "initials": "A"}, {"family": "Slowther", "given": "A-M", "initials": "AM"}], "type": "journal article", "published": "2020-11-03", "journal": {"title": "Anaesthesia", "issn": "1365-2044", "volume": null, "issue": null, "issn-l": "0003-2409"}, "abstract": "Predicting who will benefit from admission to an intensive care unit is not straightforward and admission processes vary. Our aim was to understand how decisions to admit or not are made. We observed 55 decision-making events in six NHS hospitals. We interviewed 30 referring and 43 intensive care doctors about these events. We describe the nature and context of the decision-making and analysed how doctors make intensive care admission decisions. Such decisions are complex with intrinsic uncertainty, often urgent and made with incomplete information. While doctors aspire to make patient-centred decisions, key challenges include: being overworked with lack of time; limited support from senior staff; and a lack of adequate staffing in other parts of the hospital that may be compromising patient safety. To reduce decision complexity, heuristic rules based on experience are often used to help think through the problem; for example, the patient's functional status or clinical gestalt. The intensive care doctors actively managed relationships with referring doctors; acted as the hospital generalist for acutely ill patients; and brought calm to crisis situations. However, they frequently failed to elicit values and preferences from patients or family members. They were rarely explicit in balancing burdens and benefits of intensive care for patients, so consistency and equity cannot be judged. The use of a framework for intensive care admission decisions that reminds doctors to seek patient or family views and encourages explicit balancing of burdens and benefits could improve decision-making. However, a supportive, adequately resourced context is also needed.", "doi": "10.1111/anae.15272", "pmid": "33141939", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-01T14:53:02.823Z", "modified": "2020-12-01T14:53:02.834Z"}, {"entity": "publication", "iuid": "fa9477a93058403489aaf9882b81d38a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa9477a93058403489aaf9882b81d38a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa9477a93058403489aaf9882b81d38a"}}, "title": "COVID-19 case-fatality rate and demographic and socioeconomic influencers: worldwide spatial regression analysis based on country-level data.", "authors": [{"family": "Cao", "given": "Yang", "initials": "Y", "orcid": "0000-0002-3552-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7594ca0fdf2d4f238ca04a788a405cdb.json"}}, {"family": "Hiyoshi", "given": "Ayako", "initials": "A"}, {"family": "Montgomery", "given": "Scott", "initials": "S", "orcid": "0000-0001-6328-5494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/601e7c2c4fa3497d91a6cef8f39b404d.json"}}], "type": "journal article", "published": "2020-11-03", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "10", "issue": "11", "pages": "e043560"}, "abstract": "To investigate the influence of demographic and socioeconomic factors on the COVID-19 case-fatality rate (CFR) globally.\n\nPublicly available register-based ecological study.\n\nTwo hundred and nine countries/territories in the world.\n\nAggregated data including 10 445 656 confirmed COVID-19 cases.\n\nCOVID-19 CFR and crude cause-specific death rate were calculated using country-level data from the Our World in Data website.\n\nThe average of country/territory-specific COVID-19 CFR is about 2%-3% worldwide and higher than previously reported at 0.7%-1.3%. A doubling in size of a population is associated with a 0.48% (95% CI 0.25% to 0.70%) increase in COVID-19 CFR, and a doubling in the proportion of female smokers is associated with a 0.55% (95% CI 0.09% to 1.02%) increase in COVID-19 CFR. The open testing policies are associated with a 2.23% (95% CI 0.21% to 4.25%) decrease in CFR. The strictness of anti-COVID-19 measures was not statistically significantly associated with CFR overall, but the higher Stringency Index was associated with higher CFR in higher-income countries with active testing policies (regression coefficient beta=0.14, 95% CI 0.01 to 0.27). Inverse associations were found between cardiovascular disease death rate and diabetes prevalence and CFR.\n\nThe association between population size and COVID-19 CFR may imply the healthcare strain and lower treatment efficiency in countries with large populations. The observed association between smoking in women and COVID-19 CFR might be due to the finding that the proportion of female smokers reflected broadly the income level of a country. When testing is warranted and healthcare resources are sufficient, strict quarantine and/or lockdown measures might result in excess deaths in underprivileged populations. Spatial dependence and temporal trends in the data should be taken into account in global joint strategy and/or policy making against the COVID-19 pandemic.", "doi": "10.1136/bmjopen-2020-043560", "pmid": "33148769", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7640588"}, {"db": "pii", "key": "bmjopen-2020-043560"}], "notes": [], "created": "2020-11-27T10:09:42.512Z", "modified": "2023-06-19T14:35:50.521Z"}, {"entity": "publication", "iuid": "bfd1e58754834c7199f78cfb8051d92a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bfd1e58754834c7199f78cfb8051d92a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bfd1e58754834c7199f78cfb8051d92a"}}, "title": "The COVID-19 pandemic: How predictive analysis, artificial intelligence and GIS can be integrated into a clinical command system to improve disaster response and preparedness.", "authors": [{"family": "Hertelendy", "given": "Attila J", "initials": "AJ"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}, {"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}], "type": "letter", "published": "2020-11-02", "journal": {"title": "Am J Emerg Med", "issn": "1532-8171", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.ajem.2020.10.049", "pmid": "33160803", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0735-6757(20)30945-1"}, {"db": "pmc", "key": "PMC7605801"}], "notes": [], "created": "2020-12-01T14:23:39.044Z", "modified": "2020-12-01T14:23:55.056Z"}, {"entity": "publication", "iuid": "9115762056744c4eb68986440242c8dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9115762056744c4eb68986440242c8dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9115762056744c4eb68986440242c8dd"}}, "title": "Epidemiological and Clinical Characteristics of COVID-19 in Children: A Systematic Review and Meta-Analysis.", "authors": [{"family": "Li", "given": "Bingbing", "initials": "B"}, {"family": "Zhang", "given": "Shan", "initials": "S"}, {"family": "Zhang", "given": "Ruili", "initials": "R"}, {"family": "Chen", "given": "Xi", "initials": "X"}, {"family": "Wang", "given": "Yong", "initials": "Y"}, {"family": "Zhu", "given": "Changlian", "initials": "C"}], "type": "systematic review", "published": "2020-11-02", "journal": {"title": "Front Pediatr", "issn": "2296-2360", "volume": "8", "issue": null, "pages": "591132", "issn-l": "2296-2360"}, "abstract": "Given the relatively low rate and limited publicly available data regarding children with SARS-CoV-2 infection, this knowledge gap should be addressed with urgency. This systematic review with meta-analysis aimed to evaluate the epidemiological spectrum and clinical characteristics of children infected with SARS-CoV-2. Relevant international and Chinese public databases were systematically searched to identify all case studies from January 1, 2020 to May 7, 2020. This study consisted of 96 studies involving 7004 cases. The mean age of pediatric cases was 6.48 years (95% CI 52.0-77.5), 90% had household contact, and 66% presented with mild to moderate clinical syndromes. The main symptoms were fever (47%, 95% CI 41-53%) and cough (42%, 95% CI 36-48%). About 23% of children were asymptomatic, 27% had comorbidity, and 29% had a co-infection. The pooled mean incubation period was 9.57 days (95% CI 7.70-11.44). The shedding of SARS-CoV-2 in the upper respiratory tract lasted 11.43 days, and 75% of patients had virus particles in their stool. A total of 34% of the children had neutropenia and 26% had lymphocytosis. Interferon-alpha (81%) was the most commonly used antiviral drug in the children. The discharge and death rates were 79 and 1%. In conclusion, the transmissibility of pediatric COVID-19 should be not ignored because of the relatively long incubation period, shedding duration, and mild clinical syndromes.", "doi": "10.3389/fped.2020.591132", "pmid": "33224909", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7667131"}], "notes": [], "created": "2020-11-26T12:32:45.094Z", "modified": "2020-11-26T12:32:45.103Z"}, {"entity": "publication", "iuid": "28640e6c60bf474198a68db6a0463bf6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/28640e6c60bf474198a68db6a0463bf6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/28640e6c60bf474198a68db6a0463bf6"}}, "title": "Expansion of SARS-CoV-2-Specific Antibody-Secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients.", "authors": [{"family": "Varnait\u0117", "given": "Renata", "initials": "R", "orcid": "0000-0001-9391-9291", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05a03781d1c84aad85895298c193c575.json"}}, {"family": "Garc\u00eda", "given": "Marina", "initials": "M", "orcid": "0000-0002-9130-3933", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5b109d7a54e4c05a48e0f21c4432be6.json"}}, {"family": "Glans", "given": "Hedvig", "initials": "H", "orcid": "0000-0002-7401-2245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ffccfdfb5ffa4d09ab2ae87655f30585.json"}}, {"family": "Maleki", "given": "Kimia T", "initials": "KT", "orcid": "0000-0001-5382-5477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c0313be527f49c0b41a37115a68408d.json"}}, {"family": "Sandberg", "given": "John Tyler", "initials": "JT", "orcid": "0000-0001-6747-6933", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dfe4b6f5f2f24420bd78d7ae9b71e2d4.json"}}, {"family": "Tynell", "given": "Janne", "initials": "J"}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f2dc27d02294a15a6f691be6aab641f.json"}}, {"family": "Lagerqvist", "given": "Nina", "initials": "N"}, {"family": "Asgeirsson", "given": "Hilmir", "initials": "H", "orcid": "0000-0003-3869-8021", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/870e3520475b41f8a4f39744b1ecb3ea.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG", "orcid": "0000-0003-0908-7387", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48a59f01e46c41038301a586178e8e2a.json"}}, {"family": "Ahl\u00e9n", "given": "Gustaf", "initials": "G"}, {"family": "Frelin", "given": "Lars", "initials": "L"}, {"family": "S\u00e4llberg", "given": "Matti", "initials": "M"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S", "orcid": "0000-0002-2446-4323", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/363ff940d9c64575a11bd45372927b2c.json"}}], "type": "journal article", "published": "2020-11-01", "journal": {"title": "J Immunol", "issn": "1550-6606", "issn-l": null, "volume": "205", "issue": "9", "pages": "2437-2446"}, "abstract": "Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in late 2019 and has since become a global pandemic. Pathogen-specific Abs are typically a major predictor of protective immunity, yet human B cell and Ab responses during COVID-19 are not fully understood. In this study, we analyzed Ab-secreting cell and Ab responses in 20 hospitalized COVID-19 patients. The patients exhibited typical symptoms of COVID-19 and presented with reduced lymphocyte numbers and increased T cell and B cell activation. Importantly, we detected an expansion of SARS-CoV-2 nucleocapsid protein-specific Ab-secreting cells in all 20 COVID-19 patients using a multicolor FluoroSpot Assay. Out of the 20 patients, 16 had developed SARS-CoV-2-neutralizing Abs by the time of inclusion in the study. SARS-CoV-2-specific IgA, IgG, and IgM Ab levels positively correlated with SARS-CoV-2-neutralizing Ab titers, suggesting that SARS-CoV-2-specific Ab levels may reflect the titers of neutralizing Abs in COVID-19 patients during the acute phase of infection. Last, we showed that IL-6 and C-reactive protein serum concentrations were higher in patients who were hospitalized for longer, supporting the recent observations that IL-6 and C-reactive protein could be used as markers for COVID-19 severity. Altogether, this study constitutes a detailed description of clinical and immunological parameters in 20 COVID-19 patients, with a focus on B cell and Ab responses, and describes tools to study immune responses to SARS-CoV-2 infection and vaccination.", "doi": "10.4049/jimmunol.2000717", "pmid": "32878912", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC7576114"}, {"db": "pii", "key": "jimmunol.2000717"}], "notes": [], "created": "2020-11-04T14:50:45.425Z", "modified": "2023-06-19T14:32:55.754Z"}, {"entity": "publication", "iuid": "5f5f0603074945a8bcfdfbded42b74f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f5f0603074945a8bcfdfbded42b74f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f5f0603074945a8bcfdfbded42b74f9"}}, "title": "Addressing Healthcare Gaps in Sweden during the COVID-19 Outbreak: On Community Outreach and Empowering Ethnic Minority Groups in a Digitalized Context.", "authors": [{"family": "Valeriani", "given": "Giuseppe", "initials": "G"}, {"family": "Sarajlic Vukovic", "given": "Iris", "initials": "I"}, {"family": "Lindegaard", "given": "Tomas", "initials": "T"}, {"family": "Felizia", "given": "Roberto", "initials": "R"}, {"family": "Mollica", "given": "Richard", "initials": "R"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}], "type": "journal article", "published": "2020-11-01", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "volume": "8", "issue": "4", "issn-l": null}, "abstract": "Since its early stages, the COVID-19 pandemic has interacted with existing divides by ethnicity and socioeconomic statuses, exacerbating further inequalities in high-income countries. The Swedish public health strategy, built on mutual trust between the government and the society and giving the responsibility to the individual, has been criticized for not applying a dedicated and more diverse strategy for most disadvantaged migrants in dealing with the pandemic. In order to mitigate the unequal burden on the marginalized members of society, increasing efforts have been addressed to digital health technologies. Despite the strong potential of providing collective public health benefits, especially in a highly digitalized context as Sweden, need for a stronger cooperation between the public health authorities and migrant community leaders, representatives of migrant associations, religious leaders and other influencers of disadvantaged groups has emerged. Suggestions are presented on more culturally congruent, patient-centered health care services aimed to empower people to participate in a more effective public health response to the COVID-19 crisis.", "doi": "10.3390/healthcare8040445", "pmid": "33139619", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "healthcare8040445"}], "notes": [], "created": "2020-12-01T14:56:27.725Z", "modified": "2020-12-01T14:56:27.749Z"}, {"entity": "publication", "iuid": "f34afa2a75de4523ae268c8024729da5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f34afa2a75de4523ae268c8024729da5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f34afa2a75de4523ae268c8024729da5"}}, "title": "Work at inpatient care units is associated with an increased risk of SARS-CoV-2 infection; a cross-sectional study of 8679 healthcare workers in Sweden.", "authors": [{"family": "Lidstr\u00f6m", "given": "Anna-Karin", "initials": "AK"}, {"family": "Sund", "given": "Fredrik", "initials": "F"}, {"family": "Albinsson", "given": "Bo", "initials": "B"}, {"family": "Lindb\u00e4ck", "given": "Johan", "initials": "J"}, {"family": "Westman", "given": "Gabriel", "initials": "G"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "volume": "125", "issue": "4", "pages": "305-310", "issn-l": "0300-9734"}, "abstract": "During the Covid-19 pandemic, the protection of healthcare workers has been in focus throughout the world, but the availability and quality of personal protective equipment has at times and in some settings been suboptimal.\n\nA total of 8679 healthcare workers and healthcare support staff in the county of Uppsala, north of Stockholm, were included in this cross-sectional study. All subjects were analysed for IgG anti-SARS-CoV-2, and predictors for positive serostatus were analysed in a logistic regression model including demographic parameters and self-reported employment characteristics.\n\nOverall, 577 (6.6%) were classified as seropositive, with no statistically significant differences between healthcare workers and support staff. Among healthcare workers, age (OR 0.987 per year, 95% CI 0.980-0.995), time to sampling (OR 1.019 per day, 95% CI 1.004-1.035), and employment at an outpatient care unit (OR 0.620, 95% CI 0.487-0.788) were statistically significantly associated with risk of infection. Covid-19 specific units were not at particular risk, compared to other units with comparable characteristics and staff demography.\n\nOur findings indicate that SARS-CoV-2 transmission is related to inpatient healthcare work, and illustrate the need for a high standard of basic hygiene routines in all inpatient care settings.", "doi": "10.1080/03009734.2020.1793039", "pmid": "32684119", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7594729"}], "notes": [], "created": "2020-11-18T17:32:37.256Z", "modified": "2021-02-26T08:45:48.851Z"}, {"entity": "publication", "iuid": "bdb516f3c98f4f7098054985e3b15024", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bdb516f3c98f4f7098054985e3b15024.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bdb516f3c98f4f7098054985e3b15024"}}, "title": "Will coronavirus disease (COVID-19) have an impact on antimicrobial resistance?", "authors": [{"family": "Monnet", "given": "Dominique L", "initials": "DL"}, {"family": "Harbarth", "given": "Stephan", "initials": "S"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "45", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.45.2001886", "pmid": "33183403", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7667630"}], "notes": [], "created": "2020-11-30T16:27:06.332Z", "modified": "2020-11-30T16:27:06.344Z"}, {"entity": "publication", "iuid": "884d64d5e3ab4443b5b428260d57c4e9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/884d64d5e3ab4443b5b428260d57c4e9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/884d64d5e3ab4443b5b428260d57c4e9"}}, "title": "Virological surveillance of influenza viruses in the WHO European Region in 2019/20 - impact of the COVID-19 pandemic.", "authors": [{"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "Pereyaslov", "given": "Dmitriy", "initials": "D"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "Prosenc", "given": "Katarina", "initials": "K"}, {"family": "Alm", "given": "Erik", "initials": "E"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Fielding", "given": "James", "initials": "J"}, {"family": "Sneiderman", "given": "Miriam", "initials": "M"}, {"family": "Martinuka", "given": "Oksana", "initials": "O"}, {"family": "Celentano", "given": "Lucia Pastore", "initials": "LP"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "WHO European Region influenza surveillance network", "given": "", "initials": ""}, {"family": "WHO European Region Influenza Surveillance Network author list", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "25", "issue": "46", "pages": null}, "abstract": "The COVID-19 pandemic negatively impacted the 2019/20 WHO European Region influenza surveillance. Compared with previous 4-year averages, antigenic and genetic characterisations decreased by 17% (3,140 vs 2,601) and 24% (4,474 vs 3,403). Of subtyped influenza A viruses, 56% (26,477/47,357) were A(H1)pdm09, 44% (20,880/47,357) A(H3). Of characterised B viruses, 98% (4,585/4,679) were B/Victoria. Considerable numbers of viruses antigenically differed from northern hemisphere vaccine components. In 2020/21, maintaining influenza virological surveillance, while supporting SARS-CoV-2 surveillance is crucial.", "doi": "10.2807/1560-7917.ES.2020.25.46.2001822", "pmid": "33213683", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7678039"}], "notes": [], "created": "2020-11-30T16:03:50.371Z", "modified": "2021-02-26T08:45:48.443Z"}, {"entity": "publication", "iuid": "cdca526a6b5d44c985559cb88dbd3572", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cdca526a6b5d44c985559cb88dbd3572.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cdca526a6b5d44c985559cb88dbd3572"}}, "title": "Using an integrated social cognition model to predict COVID-19 preventive behaviours.", "authors": [{"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Imani", "given": "Vida", "initials": "V"}, {"family": "Majd", "given": "Nilofar Rajabi", "initials": "NR"}, {"family": "Ghasemi", "given": "Zahra", "initials": "Z"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Hamilton", "given": "Kyra", "initials": "K"}, {"family": "Hagger", "given": "Martin S", "initials": "MS"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Br J Health Psychol", "issn": "2044-8287", "issn-l": null, "volume": "25", "issue": "4", "pages": "981-1005"}, "abstract": "Rates of novel coronavirus disease 2019 (COVID-19) infections have rapidly increased worldwide and reached pandemic proportions. A suite of preventive behaviours have been recommended to minimize risk of COVID-19 infection in the general population. The present study utilized an integrated social cognition model to explain COVID-19 preventive behaviours in a sample from the Iranian general population.\r\n\r\nThe study adopted a three-wave prospective correlational design.\r\n\r\nMembers of the general public (N = 1,718, M age = 33.34, SD = 15.77, male = 796, female = 922) agreed to participate in the study. Participants completed self-report measures of demographic characteristics, intention, attitude, subjective norm, perceived behavioural control, and action self-efficacy at an initial data collection occasion. One week later, participants completed self-report measures of maintenance self-efficacy, action planning and coping planning, and, a further week later, measures of COVID-19 preventive behaviours. Hypothesized relationships among social cognition constructs and COVID-19 preventive behaviours according to the proposed integrated model were estimated using structural equation modelling.\r\n\r\nThe proposed model fitted the data well according to multiple goodness-of-fit criteria. All proposed relationships among model constructs were statistically significant. The social cognition constructs with the largest effects on COVID-19 preventive behaviours were coping planning (\u03b2 = .575, p < .001) and action planning (\u03b2 = .267, p < .001).\r\n\r\nCurrent findings may inform the development of behavioural interventions in health care contexts by identifying intervention targets. In particular, findings suggest targeting change in coping planning and action planning may be most effective in promoting participation in COVID-19 preventive behaviours. Statement of contribution What is already known on this subject? Curbing COVID-19 infections globally is vital to reduce severe cases and deaths in at-risk groups. Preventive behaviours like handwashing and social distancing can stem contagion of the coronavirus. Identifying modifiable correlates of COVID-19 preventive behaviours is needed to inform intervention. What does this study add? An integrated model identified predictors of COVID-19 preventive behaviours in Iranian residents. Prominent predictors were intentions, planning, self-efficacy, and perceived behavioural control. Findings provide insight into potentially modifiable constructs that interventions can target. Research should examine if targeting these factors lead to changes in COVID-19 behaviours over time.", "doi": "10.1111/bjhp.12465", "pmid": "32780891", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7436576"}], "notes": [], "created": "2020-12-07T13:30:27.584Z", "modified": "2022-11-09T08:30:26.489Z"}, {"entity": "publication", "iuid": "040f98cfd40d407c994d51d6edbcc285", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/040f98cfd40d407c994d51d6edbcc285.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/040f98cfd40d407c994d51d6edbcc285"}}, "title": "The challenge of COVID-19 and hematopoietic cell transplantation; EBMT recommendations for management of hematopoietic cell transplant recipients, their donors, and patients undergoing CAR T-cell therapy.", "authors": [{"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Mikulska", "given": "Malgorzata", "initials": "M"}, {"family": "de la Camara", "given": "Rafael", "initials": "R"}, {"family": "Basak", "given": "Grzegorz W", "initials": "GW"}, {"family": "Chabannon", "given": "Christian", "initials": "C"}, {"family": "Corbacioglu", "given": "Selim", "initials": "S"}, {"family": "Duarte", "given": "Rafael", "initials": "R"}, {"family": "Dolstra", "given": "Harry", "initials": "H"}, {"family": "Lankester", "given": "Arjan C", "initials": "AC"}, {"family": "Mohty", "given": "Mohamad", "initials": "M"}, {"family": "Montoto", "given": "Silvia", "initials": "S"}, {"family": "Murray", "given": "John", "initials": "J"}, {"family": "Peffault de Latour", "given": "R\u00e9gis", "initials": "R"}, {"family": "Snowden", "given": "John A", "initials": "JA"}, {"family": "Yakoub-Agha", "given": "Ibrahim", "initials": "I"}, {"family": "Verhoeven", "given": "Bregje", "initials": "B"}, {"family": "Kr\u00f6ger", "given": "Nicolaus", "initials": "N"}, {"family": "Styczynski", "given": "Jan", "initials": "J"}, {"family": "European Society for Blood and Marrow Transplantation", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Bone Marrow Transplant", "issn": "1476-5365", "volume": "55", "issue": "11", "pages": "2071-2076", "issn-l": "0268-3369"}, "abstract": "The new coronavirus SARS-CoV-2 has rapidly spread over the world causing the disease by WHO called COVID-19. This pandemic poses unprecedented stress on the health care system including programs performing allogeneic and autologous hematopoietic cell transplantation (HCT) and cellular therapy such as with CAR T cells. Risk factors for severe disease include age and predisposing conditions such as cancer. The true impact on stem cell transplant and CAR T-cell recipients in unknown. The European Society for Blood and Marrow Transplantation (EBMT) has therefore developed recommendations for transplant programs and physicians caring for these patients. These guidelines were developed by experts from the Infectious Diseases Working Party and have been endorsed by EBMT's scientific council and board. This work intends to provide guidelines for transplant centers, management of transplant candidates and recipients, and donor issues until the COVID-19 pandemic has passed.", "doi": "10.1038/s41409-020-0919-0", "pmid": "32404975", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41409-020-0919-0"}, {"db": "pmc", "key": "PMC7220575"}], "notes": [], "created": "2020-11-26T12:17:04.466Z", "modified": "2020-12-10T08:45:08.633Z"}, {"entity": "publication", "iuid": "52852cdfbb244df3b213b74fd505f389", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/52852cdfbb244df3b213b74fd505f389.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/52852cdfbb244df3b213b74fd505f389"}}, "title": "The Potential of Low Molecular Weight Heparin to Mitigate Cytokine Storm in Severe COVID-19 Patients: A Retrospective Cohort Study.", "authors": [{"family": "Shi", "given": "Chen", "initials": "C"}, {"family": "Wang", "given": "Cong", "initials": "C"}, {"family": "Wang", "given": "Hanxiang", "initials": "H"}, {"family": "Yang", "given": "Chao", "initials": "C"}, {"family": "Cai", "given": "Fei", "initials": "F"}, {"family": "Zeng", "given": "Fang", "initials": "F"}, {"family": "Cheng", "given": "Fang", "initials": "F"}, {"family": "Liu", "given": "Yihui", "initials": "Y"}, {"family": "Zhou", "given": "Taotao", "initials": "T"}, {"family": "Deng", "given": "Bin", "initials": "B"}, {"family": "Vlodavsky", "given": "Israel", "initials": "I"}, {"family": "Li", "given": "Jin-Ping", "initials": "JP"}, {"family": "Zhang", "given": "Yu", "initials": "Y"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Clin Transl Sci", "issn": "1752-8062", "issn-l": "1752-8054", "volume": "13", "issue": "6", "pages": "1087-1095"}, "abstract": "On March 11, 2020, the World Health Organization declared its assessment of coronavirus disease 2019 (COVID-19) as a global pandemic. However, specific anti-severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) drugs are still under development, and patients are managed by multiple complementary treatments. We performed a retrospective analysis to compare and evaluate the effect of low molecular weight heparin (LMWH) treatment on disease progression. For this purpose, the clinical records and laboratory indicators were extracted from electronic medical records of 42 patients with COVID-19 (21 of whom were treated with LMWH, and 21 without LMWH) hospitalized (Union Hospital of Huazhong University of Science and Technology) from February 1 to March 15, 2020. Changes in the percentage of lymphocytes before and after LMWH treatment were significantly different from those in the control group (P = 0.011). Likewise, changes in the levels of D-dimer and fibrinogen degradation products in the LMWH group before and after treatment were significantly different from those in the control group (P = 0.035). Remarkably, IL-6 levels were significantly reduced after LMWH treatment (P = 0.006), indicating that, besides other beneficial properties, LMWH may exert an anti-inflammatory effect and attenuate in part the \"cytokine storm\" induced by the virus. Our results support the use of LMWH as a potential therapeutic drug for the treatment of COVID-19, paving the way for a subsequent well-controlled clinical study.", "doi": "10.1111/cts.12880", "pmid": "32881340", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7719364"}], "notes": [], "created": "2020-11-22T09:54:40.820Z", "modified": "2023-06-19T15:37:44.972Z"}, {"entity": "publication", "iuid": "30c03419298947d887addc0c0ff7cb9b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/30c03419298947d887addc0c0ff7cb9b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/30c03419298947d887addc0c0ff7cb9b"}}, "title": "Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future.", "authors": [{"family": "Mok", "given": "Vincent C T", "initials": "VCT"}, {"family": "Pendlebury", "given": "Sarah", "initials": "S"}, {"family": "Wong", "given": "Adrian", "initials": "A"}, {"family": "Alladi", "given": "Suvarna", "initials": "S"}, {"family": "Au", "given": "Lisa", "initials": "L"}, {"family": "Bath", "given": "Philip M", "initials": "PM"}, {"family": "Biessels", "given": "Geert Jan", "initials": "GJ"}, {"family": "Chen", "given": "Christopher", "initials": "C"}, {"family": "Cordonnier", "given": "Charlotte", "initials": "C"}, {"family": "Dichgans", "given": "Martin", "initials": "M"}, {"family": "Dominguez", "given": "Jacqueline", "initials": "J"}, {"family": "Gorelick", "given": "Philip B", "initials": "PB"}, {"family": "Kim", "given": "SangYun", "initials": "S"}, {"family": "Kwok", "given": "Timothy", "initials": "T"}, {"family": "Greenberg", "given": "Steven M", "initials": "SM"}, {"family": "Jia", "given": "Jianping", "initials": "J"}, {"family": "Kalaria", "given": "Rajesh", "initials": "R"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Naegandran", "given": "Kandiah", "initials": "K"}, {"family": "Lam", "given": "Linda C W", "initials": "LCW"}, {"family": "Lam", "given": "Bonnie Yin Ka", "initials": "BYK"}, {"family": "Lee", "given": "Allen T C", "initials": "ATC"}, {"family": "Markus", "given": "Hugh S", "initials": "HS"}, {"family": "O'Brien", "given": "John", "initials": "J"}, {"family": "Pai", "given": "Ming-Chyi", "initials": "MC"}, {"family": "Pantoni", "given": "Leonardo", "initials": "L"}, {"family": "Sachdev", "given": "Perminder", "initials": "P"}, {"family": "Skoog", "given": "Ingmar", "initials": "I"}, {"family": "Smith", "given": "Eric E", "initials": "EE"}, {"family": "Srikanth", "given": "Velandai", "initials": "V"}, {"family": "Suh", "given": "Guk-Hee", "initials": "GH"}, {"family": "Wardlaw", "given": "Joanna", "initials": "J"}, {"family": "Ko", "given": "Ho", "initials": "H"}, {"family": "Black", "given": "Sandra E", "initials": "SE"}, {"family": "Scheltens", "given": "Philip", "initials": "P"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Alzheimers Dement", "issn": "1552-5279", "volume": "16", "issue": "11", "pages": "1571-1581", "issn-l": "1552-5260"}, "abstract": "We have provided an overview on the profound impact of COVID-19 upon older people with Alzheimer's disease and other dementias and the challenges encountered in our management of dementia in different health-care settings, including hospital, out-patient, care homes, and the community during the COVID-19 pandemic. We have also proposed a conceptual framework and practical suggestions for health-care providers in tackling these challenges, which can also apply to the care of older people in general, with or without other neurological diseases, such as stroke or parkinsonism. We believe this review will provide strategic directions and set standards for health-care leaders in dementia, including governmental bodies around the world in coordinating emergency response plans for protecting and caring for older people with dementia amid the COIVD-19 outbreak, which is likely to continue at varying severity in different regions around the world in the medium term.", "doi": "10.1002/alz.12143", "pmid": "32789951", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7436526"}], "notes": [], "created": "2020-11-26T12:18:00.247Z", "modified": "2020-11-30T08:41:01.767Z"}, {"entity": "publication", "iuid": "9a77c42026f74ace999a6c8baae5ed4a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9a77c42026f74ace999a6c8baae5ed4a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9a77c42026f74ace999a6c8baae5ed4a"}}, "title": "Sports balls as potential SARS-CoV-2 transmission vectors.", "authors": [{"family": "Pelisser", "given": "Michel", "initials": "M"}, {"family": "Thompson", "given": "Joe", "initials": "J"}, {"family": "Majra", "given": "Dasha", "initials": "D"}, {"family": "Youhanna", "given": "Sonia", "initials": "S"}, {"family": "Stebbing", "given": "Justin", "initials": "J"}, {"family": "Davies", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Public Health Pract (Oxf)", "issn": "2666-5352", "volume": "1", "pages": "100029", "issn-l": null}, "abstract": "Objects passed from one player to another have not been assessed for their ability to transmit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We found that the surface of sport balls, notably a football, tennis ball, golf ball, and cricket ball could not harbour inactivated virus when it was swabbed onto the surface, even for 30 \u200bs. However, when high concentrations of 5000 \u200bdC/mL and 10,000 \u200bdC/mL are directly pipetted onto the balls, it could be detected after for short time periods. Sports objects can only harbour inactivated SARS-CoV-2 under specific, directly transferred conditions, but wiping with a dry tissue or moist 'baby wipe' or dropping and rolling the balls removes all detectable viral traces. This has helpful implications to sporting events.", "doi": "10.1016/j.puhip.2020.100029", "pmid": "34173569", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S2666-5352(20)30028-8"}, {"db": "pmc", "key": "PMC7350886"}], "notes": [], "created": "2021-06-28T18:09:36.233Z", "modified": "2021-08-23T14:39:57.598Z"}, {"entity": "publication", "iuid": "a107d4a9a1434c93ba1cbee8a5c6ca16", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a107d4a9a1434c93ba1cbee8a5c6ca16.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a107d4a9a1434c93ba1cbee8a5c6ca16"}}, "title": "Risks to healthcare workers following tracheal intubation of patients with COVID-19: a prospective international multicentre cohort study.", "authors": [{"family": "El-Boghdadly", "given": "K", "initials": "K"}, {"family": "Wong", "given": "D J N", "initials": "DJN"}, {"family": "Owen", "given": "R", "initials": "R"}, {"family": "Neuman", "given": "M D", "initials": "MD"}, {"family": "Pocock", "given": "S", "initials": "S"}, {"family": "Carlisle", "given": "J B", "initials": "JB"}, {"family": "Johnstone", "given": "C", "initials": "C"}, {"family": "Andruszkiewicz", "given": "P", "initials": "P"}, {"family": "Baker", "given": "P A", "initials": "PA"}, {"family": "Biccard", "given": "B M", "initials": "BM"}, {"family": "Bryson", "given": "G L", "initials": "GL"}, {"family": "Chan", "given": "M T V", "initials": "MTV"}, {"family": "Cheng", "given": "M H", "initials": "MH"}, {"family": "Chin", "given": "K J", "initials": "KJ"}, {"family": "Coburn", "given": "M", "initials": "M"}, {"family": "Jonsson Fagerlund", "given": "M", "initials": "M"}, {"family": "Myatra", "given": "S N", "initials": "SN"}, {"family": "Myles", "given": "P S", "initials": "PS"}, {"family": "O'Sullivan", "given": "E", "initials": "E"}, {"family": "Pasin", "given": "L", "initials": "L"}, {"family": "Shamim", "given": "F", "initials": "F"}, {"family": "van Klei", "given": "W A", "initials": "WA"}, {"family": "Ahmad", "given": "I", "initials": "I"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Anaesthesia", "issn": "1365-2044", "issn-l": "0003-2409", "volume": "75", "issue": "11", "pages": "1437-1447"}, "abstract": "Healthcare workers involved in aerosol-generating procedures, such as tracheal intubation, may be at elevated risk of acquiring COVID-19. However, the magnitude of this risk is unknown. We conducted a prospective international multicentre cohort study recruiting healthcare workers participating in tracheal intubation of patients with suspected or confirmed COVID-19. Information on tracheal intubation episodes, personal protective equipment use and subsequent provider health status was collected via self-reporting. The primary endpoint was the incidence of laboratory-confirmed COVID-19 diagnosis or new symptoms requiring self-isolation or hospitalisation after a tracheal intubation episode. Cox regression analysis examined associations between the primary endpoint and healthcare worker characteristics, procedure-related factors and personal protective equipment use. Between 23 March and 2 June 2020, 1718 healthcare workers from 503 hospitals in 17 countries reported 5148 tracheal intubation episodes. The overall incidence of the primary endpoint was 10.7% over a median (IQR [range]) follow-up of 32 (18-48 [0-116]) days. The cumulative incidence within 7, 14 and 21 days of the first tracheal intubation episode was 3.6%, 6.1% and 8.5%, respectively. The risk of the primary endpoint varied by country and was higher in women, but was not associated with other factors. Around 1 in 10 healthcare workers involved in tracheal intubation of patients with suspected or confirmed COVID-19 subsequently reported a COVID-19 outcome. This has human resource implications for institutional capacity to deliver essential healthcare services, and wider societal implications for COVID-19 transmission.", "doi": "10.1111/anae.15170", "pmid": "32516833", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7300828"}], "notes": [], "created": "2020-11-25T09:57:47.346Z", "modified": "2022-11-09T08:32:15.026Z"}, {"entity": "publication", "iuid": "9b49421a30994ffc84789e00e0c9f02d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b49421a30994ffc84789e00e0c9f02d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b49421a30994ffc84789e00e0c9f02d"}}, "title": "Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis: a multinational, retrospective study.", "authors": [{"family": "Lane", "given": "Jennifer C E", "initials": "JCE"}, {"family": "Weaver", "given": "James", "initials": "J"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "Abrahao", "given": "Maria Tereza F", "initials": "MTF"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Biedermann", "given": "Patricia", "initials": "P"}, {"family": "Banda", "given": "Juan M", "initials": "JM"}, {"family": "Burn", "given": "Edward", "initials": "E"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "Conover", "given": "Mitchell M", "initials": "MM"}, {"family": "Culhane", "given": "Aedin C", "initials": "AC"}, {"family": "Davydov", "given": "Alexander", "initials": "A"}, {"family": "DuVall", "given": "Scott L", "initials": "SL"}, {"family": "Dymshyts", "given": "Dmitry", "initials": "D"}, {"family": "Fernandez-Bertolin", "given": "Sergio", "initials": "S"}, {"family": "Fi\u0161ter", "given": "Kristina", "initials": "K"}, {"family": "Hardin", "given": "Jill", "initials": "J"}, {"family": "Hester", "given": "Laura", "initials": "L"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Kaas-Hansen", "given": "Benjamin Skov", "initials": "BS"}, {"family": "Kent", "given": "Seamus", "initials": "S"}, {"family": "Khosla", "given": "Sajan", "initials": "S"}, {"family": "Kolovos", "given": "Spyros", "initials": "S"}, {"family": "Lambert", "given": "Christophe G", "initials": "CG"}, {"family": "van der Lei", "given": "Johan", "initials": "J"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Makadia", "given": "Rupa", "initials": "R"}, {"family": "Margulis", "given": "Andrea V", "initials": "AV"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Mehta", "given": "Paras", "initials": "P"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Morgan-Stewart", "given": "Henry", "initials": "H"}, {"family": "Mosseveld", "given": "Mees", "initials": "M"}, {"family": "Newby", "given": "Danielle", "initials": "D"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Park", "given": "Rae Woong", "initials": "RW"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A"}, {"family": "Rao", "given": "Gowtham A", "initials": "GA"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Reps", "given": "Jenna", "initials": "J"}, {"family": "Rijnbeek", "given": "Peter", "initials": "P"}, {"family": "Sathappan", "given": "Selva Muthu Kumaran", "initials": "SMK"}, {"family": "Schuemie", "given": "Martijn", "initials": "M"}, {"family": "Seager", "given": "Sarah", "initials": "S"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Shoaibi", "given": "Azza", "initials": "A"}, {"family": "Spotnitz", "given": "Matthew", "initials": "M"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Torre", "given": "Carmen O", "initials": "CO"}, {"family": "Vizcaya", "given": "David", "initials": "D"}, {"family": "Wen", "given": "Haini", "initials": "H"}, {"family": "de Wilde", "given": "Marcel", "initials": "M"}, {"family": "Xie", "given": "Junqing", "initials": "J"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhuk", "given": "Oleg", "initials": "O"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "OHDSI-COVID-19 consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Lancet Rheumatol", "issn": "2665-9913", "volume": "2", "issue": "11", "pages": "e698-e711", "issn-l": null}, "abstract": "Hydroxychloroquine, a drug commonly used in the treatment of rheumatoid arthritis, has received much negative publicity for adverse events associated with its authorisation for emergency use to treat patients with COVID-19 pneumonia. We studied the safety of hydroxychloroquine, alone and in combination with azithromycin, to determine the risk associated with its use in routine care in patients with rheumatoid arthritis.\n\nIn this multinational, retrospective study, new user cohort studies in patients with rheumatoid arthritis aged 18 years or older and initiating hydroxychloroquine were compared with those initiating sulfasalazine and followed up over 30 days, with 16 severe adverse events studied. Self-controlled case series were done to further establish safety in wider populations, and included all users of hydroxychloroquine regardless of rheumatoid arthritis status or indication. Separately, severe adverse events associated with hydroxychloroquine plus azithromycin (compared with hydroxychloroquine plus amoxicillin) were studied. Data comprised 14 sources of claims data or electronic medical records from Germany, Japan, the Netherlands, Spain, the UK, and the USA. Propensity score stratification and calibration using negative control outcomes were used to address confounding. Cox models were fitted to estimate calibrated hazard ratios (HRs) according to drug use. Estimates were pooled where the I2 value was less than 0\u00b74.\n\nThe study included 956 374 users of hydroxychloroquine, 310 350 users of sulfasalazine, 323 122 users of hydroxychloroquine plus azithromycin, and 351 956 users of hydroxychloroquine plus amoxicillin. No excess risk of severe adverse events was identified when 30-day hydroxychloroquine and sulfasalazine use were compared. Self-controlled case series confirmed these findings. However, long-term use of hydroxychloroquine appeared to be associated with increased cardiovascular mortality (calibrated HR 1\u00b765 [95% CI 1\u00b712-2\u00b744]). Addition of azithromycin appeared to be associated with an increased risk of 30-day cardiovascular mortality (calibrated HR 2\u00b719 [95% CI 1\u00b722-3\u00b795]), chest pain or angina (1\u00b715 [1\u00b705-1\u00b726]), and heart failure (1\u00b722 [1\u00b702-1\u00b745]).\n\nHydroxychloroquine treatment appears to have no increased risk in the short term among patients with rheumatoid arthritis, but in the long term it appears to be associated with excess cardiovascular mortality. The addition of azithromycin increases the risk of heart failure and cardiovascular mortality even in the short term. We call for careful consideration of the benefit-risk trade-off when counselling those on hydroxychloroquine treatment.\n\nNational Institute for Health Research (NIHR) Oxford Biomedical Research Centre, NIHR Senior Research Fellowship programme, US National Institutes of Health, US Department of Veterans Affairs, Janssen Research and Development, IQVIA, Korea Health Industry Development Institute through the Ministry of Health and Welfare Republic of Korea, Versus Arthritis, UK Medical Research Council Doctoral Training Partnership, Foundation Alfonso Martin Escudero, Innovation Fund Denmark, Novo Nordisk Foundation, Singapore Ministry of Health's National Medical Research Council Open Fund Large Collaborative Grant, VINCI, Innovative Medicines Initiative 2 Joint Undertaking, EU's Horizon 2020 research and innovation programme, and European Federation of Pharmaceutical Industries and Associations.", "doi": "10.1016/S2665-9913(20)30276-9", "pmid": "32864627", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "http://evidence.ohdsi.org:3838/Covid19EstimationHydroxychloroquine/", "description": "Data aggregated by data source"}], "notes": [], "created": "2020-12-07T10:13:23.488Z", "modified": "2021-02-26T08:45:48.505Z"}, {"entity": "publication", "iuid": "ac2573f14bbc4fd98be9ce7ae7202b55", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac2573f14bbc4fd98be9ce7ae7202b55.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac2573f14bbc4fd98be9ce7ae7202b55"}}, "title": "Residential context and COVID-19 mortality among adults aged 70 years and older in Stockholm: a population-based, observational study using individual-level data.", "authors": [{"family": "Brand\u00e9n", "given": "Maria", "initials": "M"}, {"family": "Aradhya", "given": "Siddartha", "initials": "S"}, {"family": "Kolk", "given": "Martin", "initials": "M"}, {"family": "H\u00e4rk\u00f6nen", "given": "Juho", "initials": "J"}, {"family": "Drefahl", "given": "Sven", "initials": "S"}, {"family": "Malmberg", "given": "Bo", "initials": "B"}, {"family": "Rostila", "given": "Mikael", "initials": "M"}, {"family": "Cederstr\u00f6m", "given": "Agneta", "initials": "A"}, {"family": "Andersson", "given": "Gunnar", "initials": "G"}, {"family": "Mussino", "given": "Eleonora", "initials": "E"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Lancet Healthy Longev", "issn": "2666-7568", "volume": "1", "issue": "2", "pages": "e80-e88", "issn-l": null}, "abstract": "Housing characteristics and neighbourhood context are considered risk factors for COVID-19 mortality among older adults. The aim of this study was to investigate how individual-level housing and neighbourhood characteristics are associated with COVID-19 mortality in older adults.\n\nFor this population-based, observational study, we used data from the cause-of-death register held by the Swedish National Board of Health and Welfare to identify recorded COVID-19 mortality and mortality from other causes among individuals (aged \u226570 years) in Stockholm county, Sweden, between March 12 and May 8, 2020. This information was linked to population-register data from December, 2019, including socioeconomic, demographic, and residential characteristics. We ran Cox proportional hazards regressions for the risk of dying from COVID-19 and from all other causes. The independent variables were area (m 2) per individual in the household, the age structure of the household, type of housing, confirmed cases of COVID-19 in the borough, and neighbourhood population density. All models were adjusted for individual age, sex, country of birth, income, and education.\n\nOf 279 961 individuals identified to be aged 70 years or older on March 12, 2020, and residing in Stockholm in December, 2019, 274 712 met the eligibility criteria and were included in the study population. Between March 12 and May 8, 2020, 3386 deaths occurred, of which 1301 were reported as COVID-19 deaths. In fully adjusted models, household and neighbourhood characteristics were independently associated with COVID-19 mortality among older adults. Compared with living in a household with individuals aged 66 years or older, living with someone of working age (<66 years) was associated with increased COVID-19 mortality (hazard ratio 1\u00b76; 95% CI 1\u00b73-2\u00b70). Living in a care home was associated with an increased risk of COVID-19 mortality (4\u00b71; 3\u00b75-4\u00b79) compared with living in independent housing. Living in neighbourhoods with the highest population density (\u22655000 individuals per km 2) was associated with higher COVID-19 mortality (1\u00b77; 1\u00b71-2\u00b74) compared with living in the least densely populated neighbourhoods (0 to <150 individuals per km2).\n\nClose exposure to working-age household members and neighbours is associated with increased COVID-19 mortality among older adults. Similarly, living in a care home is associated with increased mortality, potentially through exposure to visitors and care workers, but also due to poor underlying health among care-home residents. These factors should be considered when developing strategies to protect this group.\n\nSwedish Research Council for Health, Working Life and Welfare (FORTE), Swedish Foundation for Humanities and Social Sciences.", "doi": "10.1016/S2666-7568(20)30016-7", "pmid": "33521770", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-7568(20)30016-7"}, {"db": "pmc", "key": "PMC7832817"}], "notes": [], "created": "2021-02-04T18:25:32.385Z", "modified": "2021-02-26T08:45:48.566Z"}, {"entity": "publication", "iuid": "8d3b6bf4b6704177a969022eb0453cca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d3b6bf4b6704177a969022eb0453cca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d3b6bf4b6704177a969022eb0453cca"}}, "title": "Pre-pandemic psychiatric disorders and risk of COVID-19: a UK Biobank cohort analysis.", "authors": [{"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Chen", "given": "Wenwen", "initials": "W"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Chen", "given": "Yilong", "initials": "Y"}, {"family": "Zeng", "given": "Yu", "initials": "Y"}, {"family": "Sun", "given": "Yajing", "initials": "Y"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "He", "given": "Junhui", "initials": "J"}, {"family": "Qu", "given": "Yuanyuan", "initials": "Y"}, {"family": "Lu", "given": "Donghao", "initials": "D"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Lancet Healthy Longev", "issn": "2666-7568", "volume": "1", "issue": "2", "pages": "e69-e79", "issn-l": null}, "abstract": "Psychiatric morbidities have been associated with a risk of severe infections through compromised immunity, health behaviours, or both. However, data are scarce on the association between multiple types of pre-pandemic psychiatric disorders and COVID-19. We aimed to assess the association between pre-pandemic psychiatric disorders and the subsequent risk of COVID-19 using UK Biobank.\n\nFor this cohort analysis, we included participants from UK Biobank who were registered in England and excluded individuals who died before Jan 31, 2020, (the start of the COVID-19 outbreak in the UK) or had withdrawn from UK Biobank. Participants diagnosed with a psychiatric disorder before Jan 31 were included in the group of individuals with pre-pandemic psychiatric disorders, whereas participants without a diagnosis before the outbreak were included in the group of individuals without pre-pandemic psychiatric disorders. We used the Public Health England dataset, UK Biobank hospital data, and death registers to collect data on COVID-19 cases. To examine the relationship between pre-pandemic psychiatric disorders and susceptibility to COVID-19, we used logistic regression models to estimate odds ratios (ORs), controlling for multiple confounders and somatic comorbidities. Key outcomes were all COVID-19, COVID-19 specifically diagnosed in inpatient care, and COVID-19-related deaths. ORs were also estimated separately for each psychiatric disorder and on the basis of the number of pre-pandemic psychiatric disorders. As a positive disease control, we repeated analyses for hospitalisation for other infections.\n\nWe included 421 014 UK Biobank participants in our study and assessed their COVID-19 status between Jan 31 and July 26, 2020. 50 809 participants were diagnosed with psychiatric disorders before the outbreak, while 370 205 participants had no psychiatric disorders. The mean age at outbreak was 67\u00b780 years (SD 8\u00b712). We observed an elevated risk of COVID-19 among individuals with pre-pandemic psychiatric disorders compared with that of individuals without such conditions. The fully adjusted ORs were 1\u00b744 (95% CI 1\u00b728-1\u00b762) for All COVID-19 cases, 1\u00b755 (1\u00b734-1\u00b778) for Inpatient COVID-19 cases, and 2\u00b703 (1\u00b759-2\u00b759) for COVID-19-related deaths. We observed excess risk, defined as risk that increased with the number of pre-pandemic psychiatric disorders, across all diagnostic categories of pre-pandemic psychiatric disorders. We also observed an association between psychiatric disorders and elevated risk of hospitalisation due to other infections (OR 1\u00b774, 95% CI 1\u00b758-1\u00b793).\n\nOur findings suggest that pre-existing psychiatric disorders are associated with an increased risk of COVID-19. These findings underscore the need for surveillance of and care for populations with pre-existing psychiatric disorders during the COVID-19 pandemic.\n\nNational Natural Science Foundation of China.", "doi": "10.1016/S2666-7568(20)30013-1", "pmid": "33521769", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2666-7568(20)30013-1"}, {"db": "pmc", "key": "PMC7832159"}], "notes": [], "created": "2021-02-04T18:27:04.421Z", "modified": "2021-02-26T08:47:00.051Z"}, {"entity": "publication", "iuid": "e2e4e3fe83c74ab3b2dee97372c04bb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2e4e3fe83c74ab3b2dee97372c04bb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2e4e3fe83c74ab3b2dee97372c04bb1"}}, "title": "Perspectives from CO+RE: How COVID-19 changed our food systems and food security paradigms.", "authors": [{"family": "Bakalis", "given": "Serafim", "initials": "S"}, {"family": "Valdramidis", "given": "Vasilis P", "initials": "VP"}, {"family": "Argyropoulos", "given": "Dimitrios", "initials": "D"}, {"family": "Ahrne", "given": "Lilia", "initials": "L"}, {"family": "Chen", "given": "Jianshe", "initials": "J"}, {"family": "Cullen", "given": "P J", "initials": "PJ"}, {"family": "Cummins", "given": "Enda", "initials": "E"}, {"family": "Datta", "given": "Ashim K", "initials": "AK"}, {"family": "Emmanouilidis", "given": "Christos", "initials": "C"}, {"family": "Foster", "given": "Tim", "initials": "T"}, {"family": "Fryer", "given": "Peter J", "initials": "PJ"}, {"family": "Gouseti", "given": "Ourania", "initials": "O"}, {"family": "Hospido", "given": "Almudena", "initials": "A"}, {"family": "Knoerzer", "given": "Kai", "initials": "K"}, {"family": "LeBail", "given": "Alain", "initials": "A"}, {"family": "Marangoni", "given": "Alejandro G", "initials": "AG"}, {"family": "Rao", "given": "Pingfan", "initials": "P"}, {"family": "Schl\u00fcter", "given": "Oliver K", "initials": "OK"}, {"family": "Taoukis", "given": "Petros", "initials": "P"}, {"family": "Xanthakis", "given": "Epameinondas", "initials": "E"}, {"family": "Van Impe", "given": "Jan F M", "initials": "JFM"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Curr Res Food Sci", "issn": "2665-9271", "issn-l": null, "volume": "3", "issue": null, "pages": "166-172"}, "abstract": "Perspective", "doi": "10.1016/j.crfs.2020.05.003", "pmid": "32908972", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2665-9271(20)30024-1"}, {"db": "pmc", "key": "PMC7265867"}], "notes": [], "created": "2020-12-03T15:52:32.403Z", "modified": "2020-12-03T15:53:22.094Z"}, {"entity": "publication", "iuid": "d3b317fa2c674197819672c405ab928b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3b317fa2c674197819672c405ab928b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3b317fa2c674197819672c405ab928b"}}, "title": "Periodontal disease and targeted prevention using aMMP-8 point-of-care oral fluid analytics in the COVID-19 era.", "authors": [{"family": "R\u00e4is\u00e4nen", "given": "Ismo T", "initials": "IT"}, {"family": "Umeizudike", "given": "Kehinde A", "initials": "KA"}, {"family": "P\u00e4rn\u00e4nen", "given": "Pirjo", "initials": "P"}, {"family": "Heikkil\u00e4", "given": "Pia", "initials": "P"}, {"family": "Tervahartiala", "given": "Taina", "initials": "T"}, {"family": "Nwhator", "given": "Solomon O", "initials": "SO"}, {"family": "Grigoriadis", "given": "Andreas", "initials": "A"}, {"family": "Sakellari", "given": "Dimitra", "initials": "D"}, {"family": "Sorsa", "given": "Timo", "initials": "T"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Med Hypotheses", "issn": "1532-2777", "volume": "144", "issue": null, "pages": "110276", "issn-l": null}, "abstract": "Periodontal disease is a chronic multifactorial infectious and inflammatory disease associated with several chronic systemic diseases, such as diabetes, cardiovascular diseases (CVD), chronic obstructive pulmonary disease, hypertension, Alzheimer's disease and so on. These same systemic diseases have been associated with severe COVID-19 infections. Several recent studies have suggested hypotheses for the potential association between periodontal disease and severe COVID-19. Periodontal disease is also one of the most prevalent diseases globally. All this supports the importance of good oral health, also in the COVID-19 era. Thus, new strategies and approaches to identify patients at risk of periodontal disease could be beneficial to enhance secondary prevention, especially if targeted to COVID-19 risk groups. Diagnostic biomarkers for periodontal disease have been researched extensively. Potential biomarkers in oral fluid with currently available rapid non-invasive point-of-care technology, such as aMMP-8, could help to extend screening and identification of patients at risk for periodontal disease also to situations and places where professional dental expertise and equipment are limited or unavailable. i.e., nursing and care homes, and rural and distant places. The oral fluid point-of-care technologies could also be useful in the hands of medical professionals (diabetes, CVD, etc.) to identify patients at risk for undiagnosed periodontal disease and to refer them to a dentist for examination and evaluation. Finally, if there is a causality between periodontal disease and severe COVID-19 infections, these point-of-care oral fluid biomarker technologies could possibly also help in the assessment of the risk of deterioration and complications.", "doi": "10.1016/j.mehy.2020.110276", "pmid": "33254580", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0306-9877(20)32157-5"}], "notes": [], "created": "2020-12-03T08:21:29.104Z", "modified": "2021-02-26T08:45:48.749Z"}, {"entity": "publication", "iuid": "2c69f0d6d0894d9ba02912d78ac4d7c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c69f0d6d0894d9ba02912d78ac4d7c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c69f0d6d0894d9ba02912d78ac4d7c0"}}, "title": "Partisan differences in physical distancing are linked to health outcomes during the COVID-19 pandemic.", "authors": [{"family": "Gollwitzer", "given": "Anton", "initials": "A"}, {"family": "Martel", "given": "Cameron", "initials": "C"}, {"family": "Brady", "given": "William J", "initials": "WJ"}, {"family": "P\u00e4rnamets", "given": "Philip", "initials": "P"}, {"family": "Freedman", "given": "Isaac G", "initials": "IG"}, {"family": "Knowles", "given": "Eric D", "initials": "ED"}, {"family": "Van Bavel", "given": "Jay J", "initials": "JJ"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Nat Hum Behav", "issn": "2397-3374", "issn-l": "2397-3374", "volume": "4", "issue": "11", "pages": "1186-1197"}, "abstract": "Numerous polls suggest that COVID-19 is a profoundly partisan issue in the United States. Using the geotracking data of 15 million smartphones per day, we found that US counties that voted for Donald Trump (Republican) over Hillary Clinton (Democrat) in the 2016 presidential election exhibited 14% less physical distancing between March and May 2020. Partisanship was more strongly associated with physical distancing than numerous other factors, including counties' COVID-19 cases, population density, median income, and racial and age demographics. Contrary to our predictions, the observed partisan gap strengthened over time and remained when stay-at-home orders were active. Additionally, county-level consumption of conservative media (Fox News) was related to reduced physical distancing. Finally, the observed partisan differences in distancing were associated with subsequently higher COVID-19 infection and fatality growth rates in pro-Trump counties. Taken together, these data suggest that US citizens' responses to COVID-19 are subject to a deep-and consequential-partisan divide.", "doi": "10.1038/s41562-020-00977-7", "pmid": "33139897", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41562-020-00977-7"}], "notes": [], "created": "2020-11-27T10:14:47.352Z", "modified": "2022-11-09T08:32:46.853Z"}, {"entity": "publication", "iuid": "99a5591d953744048ca94c23f5b35e2a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/99a5591d953744048ca94c23f5b35e2a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/99a5591d953744048ca94c23f5b35e2a"}}, "title": "Outcomes following SARS-CoV-2 infection in liver transplant recipients: an international registry study.", "authors": [{"family": "Webb", "given": "Gwilym J", "initials": "GJ"}, {"family": "Marjot", "given": "Thomas", "initials": "T"}, {"family": "Cook", "given": "Jonathan A", "initials": "JA"}, {"family": "Aloman", "given": "Costica", "initials": "C"}, {"family": "Armstrong", "given": "Matthew J", "initials": "MJ"}, {"family": "Brenner", "given": "Erica J", "initials": "EJ"}, {"family": "Catana", "given": "Maria-Andreea", "initials": "MA"}, {"family": "Cargill", "given": "Tamsin", "initials": "T"}, {"family": "Dhanasekaran", "given": "Renumathy", "initials": "R"}, {"family": "Garc\u00eda-Ju\u00e1rez", "given": "Ignacio", "initials": "I"}, {"family": "Hagstr\u00f6m", "given": "Hannes", "initials": "H"}, {"family": "Kennedy", "given": "James M", "initials": "JM"}, {"family": "Marshall", "given": "Aileen", "initials": "A"}, {"family": "Masson", "given": "Steven", "initials": "S"}, {"family": "Mercer", "given": "Carolyn J", "initials": "CJ"}, {"family": "Perumalswami", "given": "Ponni V", "initials": "PV"}, {"family": "Ruiz", "given": "Isaac", "initials": "I"}, {"family": "Thaker", "given": "Sarang", "initials": "S"}, {"family": "Ufere", "given": "Nneka N", "initials": "NN"}, {"family": "Barnes", "given": "Eleanor", "initials": "E"}, {"family": "Barritt", "given": "Alfred S", "initials": "AS"}, {"family": "Moon", "given": "Andrew M", "initials": "AM"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Lancet Gastroenterol Hepatol", "issn": "2468-1253", "volume": "5", "issue": "11", "pages": "1008-1016", "issn-l": null}, "abstract": "Despite concerns that patients with liver transplants might be at increased risk of adverse outcomes from COVID-19 because of coexisting comorbidities and use of immunosuppressants, the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on this patient group remains unclear. We aimed to assess the clinical outcomes in these patients.\n\nIn this multicentre cohort study, we collected data on patients with laboratory-confirmed SARS-CoV-2 infection, who were older than 18 years, who had previously received a liver transplant, and for whom data had been submitted by clinicians to one of two international registries (COVID-Hep and SECURE-Cirrhosis) at the end of the patient's disease course. Patients without a known hospitalisation status or mortality outcome were excluded. For comparison, data from a contemporaneous cohort of consecutive patients with SARS-CoV-2 infection who had not received a liver transplant were collected from the electronic patient records of the Oxford University Hospitals National Health Service Foundation Trust. We compared the cohorts with regard to several outcomes (including death, hospitalisation, intensive care unit [ICU] admission, requirement for intensive care, and need for invasive ventilation). A propensity score-matched analysis was done to test for an association between liver transplant and death.\n\nBetween March 25 and June 26, 2020, data were collected for 151 adult liver transplant recipients from 18 countries (median age 60 years [IQR 47-66], 102 [68%] men, 49 [32%] women) and 627 patients who had not undergone liver transplantation (median age 73 years [44-84], 329 [52%] men, 298 [48%] women). The groups did not differ with regard to the proportion of patients hospitalised (124 [82%] patients in the liver transplant cohort vs 474 [76%] in the comparison cohort, p=0\u00b7106), or who required intensive care (47 [31%] vs 185 [30%], p=0\u00b7837). However, ICU admission (43 [28%] vs 52 [8%], p<0\u00b70001) and invasive ventilation (30 [20%] vs 32 [5%], p<0\u00b70001) were more frequent in the liver transplant cohort. 28 (19%) patients in the liver transplant cohort died, compared with 167 (27%) in the comparison cohort (p=0\u00b7046). In the propensity score-matched analysis (adjusting for age, sex, creatinine concentration, obesity, hypertension, diabetes, and ethnicity), liver transplantation did not significantly increase the risk of death in patients with SARS-CoV-2 infection (absolute risk difference 1\u00b74% [95% CI -7\u00b77 to 10\u00b74]). Multivariable logistic regression analysis showed that age (odds ratio 1\u00b706 [95% CI 1\u00b701 to 1\u00b711] per 1 year increase), serum creatinine concentration (1\u00b757 [1\u00b705 to 2\u00b736] per 1 mg/dL increase), and non-liver cancer (18\u00b730 [1\u00b796 to 170\u00b775]) were associated with death among liver transplant recipients.\n\nLiver transplantation was not independently associated with death, whereas increased age and presence of comorbidities were. Factors other than transplantation should be preferentially considered in relation to physical distancing and provision of medical care for patients with liver transplants during the COVID-19 pandemic.\n\nEuropean Association for the Study of the Liver, US National Institutes of Health, UK National Institute for Health Research.", "doi": "10.1016/S2468-1253(20)30271-5", "pmid": "32866433", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2468-1253(20)30271-5"}, {"db": "pmc", "key": "PMC7455160"}], "notes": [], "created": "2020-12-07T07:52:04.415Z", "modified": "2021-02-26T08:45:48.494Z"}, {"entity": "publication", "iuid": "da1a6cf9002a49bfa808f8b5c9f6ed12", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/da1a6cf9002a49bfa808f8b5c9f6ed12.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/da1a6cf9002a49bfa808f8b5c9f6ed12"}}, "title": "On-demand mobile health infrastructures to allow comprehensive remote atrial fibrillation and risk factor management through teleconsultation.", "authors": [{"family": "Hermans", "given": "Astrid N L", "initials": "ANL"}, {"family": "van der Velden", "given": "Rachel M J", "initials": "RMJ"}, {"family": "Gawalko", "given": "Monika", "initials": "M"}, {"family": "Verhaert", "given": "Dominique V M", "initials": "DVM"}, {"family": "Desteghe", "given": "Lien", "initials": "L"}, {"family": "Duncker", "given": "David", "initials": "D"}, {"family": "Manninger", "given": "Martin", "initials": "M"}, {"family": "Heidbuchel", "given": "Hein", "initials": "H"}, {"family": "Pisters", "given": "Ron", "initials": "R"}, {"family": "Hemels", "given": "Martin", "initials": "M"}, {"family": "Pison", "given": "Laurent", "initials": "L"}, {"family": "Sohaib", "given": "Afzal", "initials": "A"}, {"family": "Sultan", "given": "Arian", "initials": "A"}, {"family": "Steven", "given": "Daniel", "initials": "D"}, {"family": "Wijtvliet", "given": "Petra", "initials": "P"}, {"family": "Tieleman", "given": "Robert", "initials": "R"}, {"family": "Gupta", "given": "Dhiraj", "initials": "D"}, {"family": "Dobrev", "given": "Dobromir", "initials": "D"}, {"family": "Svennberg", "given": "Emma", "initials": "E"}, {"family": "Crijns", "given": "Harry J G M", "initials": "HJGM"}, {"family": "Pluymaekers", "given": "Nikki A H A", "initials": "NAHA"}, {"family": "Hendriks", "given": "Jeroen M", "initials": "JM"}, {"family": "Linz", "given": "Dominik", "initials": "D"}, {"family": "TeleCheck-AF investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Clin Cardiol", "issn": "1932-8737", "volume": "43", "issue": "11", "pages": "1232-1239", "issn-l": "0160-9289"}, "abstract": "Although novel teleconsultation solutions can deliver remote situations that are relatively similar to face-to-face interaction, remote assessment of heart rate and rhythm as well as risk factors remains challenging in patients with atrial fibrillation (AF).\n\nMobile health (mHealth) solutions can support remote AF management.\n\nHerein, we discuss available mHealth tools and strategies on how to incorporate the remote assessment of heart rate, rhythm and risk factors to allow comprehensive AF management through teleconsultation.\n\nParticularly, in the light of the coronavirus disease 2019 (COVID-19) pandemic, there is decreased capacity to see patients in the outpatient clinic and mHealth has become an important component of many AF outpatient clinics. Several validated mHealth solutions are available for remote heart rate and rhythm monitoring as well as for risk factor assessment. mHealth technologies can be used for (semi-)continuous longitudinal monitoring or for short-term on-demand monitoring, dependent on the respective requirements and clinical scenarios. As a possible solution to improve remote AF care through teleconsultation, we introduce the on-demand TeleCheck-AF mHealth approach that allows remote app-based assessment of heart rate and rhythm around teleconsultations, which has been developed and implemented during the COVID-19 pandemic in Europe.\n\nLarge scale international mHealth projects, such as TeleCheck-AF, will provide insight into the additional value and potential limitations of mHealth strategies to remotely manage AF patients. Such mHealth infrastructures may be well suited within an integrated AF-clinic, which may require redesign of practice and reform of health care systems.", "doi": "10.1002/clc.23469", "pmid": "33030259", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7661648"}], "notes": [], "created": "2020-11-26T12:36:00.991Z", "modified": "2020-11-27T12:38:58.997Z"}, {"entity": "publication", "iuid": "f55490e3a83d4d75b26c47c0548597a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f55490e3a83d4d75b26c47c0548597a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f55490e3a83d4d75b26c47c0548597a9"}}, "title": "International registry of otolaryngologist-head and neck surgeons with COVID-19.", "authors": [{"family": "Sowerby", "given": "Leigh J", "initials": "LJ"}, {"family": "Stephenson", "given": "Kate", "initials": "K"}, {"family": "Dickie", "given": "Alexander", "initials": "A"}, {"family": "Lella", "given": "Federico A Di", "initials": "FAD"}, {"family": "Jefferson", "given": "Niall", "initials": "N"}, {"family": "North", "given": "Hannah", "initials": "H"}, {"family": "De Siati", "given": "R Daniele", "initials": "RD"}, {"family": "Maunsell", "given": "Rebecca", "initials": "R"}, {"family": "Herzog", "given": "Michael", "initials": "M"}, {"family": "Nandhan", "given": "Raghu", "initials": "R"}, {"family": "Trozzi", "given": "Marilena", "initials": "M"}, {"family": "Dehgani-Mobaraki", "given": "Puya", "initials": "P"}, {"family": "Melkane", "given": "Antoine", "initials": "A"}, {"family": "Callejas", "given": "Claudio", "initials": "C"}, {"family": "Miljeteig", "given": "Harald", "initials": "H"}, {"family": "Smit", "given": "Diane", "initials": "D"}, {"family": "Reynoso", "given": "Daniel Dibildox", "initials": "DD"}, {"family": "Moura", "given": "Joao Eloi", "initials": "JE"}, {"family": "Hermansson", "given": "Ann", "initials": "A"}, {"family": "Peer", "given": "Shazia", "initials": "S"}, {"family": "Burnell", "given": "Lisa", "initials": "L"}, {"family": "Fakhry", "given": "Nicolas", "initials": "N"}, {"family": "Chiesa-Estomba", "given": "Carlos", "initials": "C"}, {"family": "\u00d6nerci \u00c7elebi", "given": "\u00d6zlem", "initials": "\u00d6"}, {"family": "Karpischenko", "given": "Sergei", "initials": "S"}, {"family": "Sobol", "given": "Steven", "initials": "S"}, {"family": "Sargi", "given": "Zoukaa", "initials": "Z"}, {"family": "Patel", "given": "Zara M", "initials": "ZM"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Int Forum Allergy Rhinol", "issn": "2042-6984", "volume": "10", "issue": "11", "pages": "1201-1208", "issn-l": "2042-6976"}, "abstract": "It has become clear that healthcare workers are at high risk, and otolaryngology has been theorized to be among the highest risk specialties for coronavirus disease 2019 (COVID-19). The purpose of this study was to detail the international impact of COVID-19 among otolaryngologists, and to identify instructional cases.\n\nCountry representatives of the Young Otolaryngologists-International Federation of Otolaryngologic Societies (YO-IFOS) surveyed otolaryngologists through various channels. Nationwide surveys were distributed in 19 countries. The gray literature and social media channels were searched to identify reported deaths of otolaryngologists from COVID-19.\n\nA total of 361 otolaryngologists were identified to have had COVID-19, and data for 325 surgeons was available for analysis. The age range was 25 to 84 years, with one-half under the age of 44 years. There were 24 deaths in the study period, with 83% over age 55 years. Source of infection was likely clinical activity in 175 (54%) cases. Prolonged exposure to a colleague was the source for 37 (11%) surgeons. Six instructional cases were identified where infections occurred during the performance of aerosol-generating operations (tracheostomy, mastoidectomy, epistaxis control, dacryocystorhinostomy, and translabyrinthine resection). In 3 of these cases, multiple operating room attendees were infected, and in 2, the surgeon succumbed to complications of COVID-19.\n\nThe etiology of reported cases within the otolaryngology community appear to stem equally from clinical activity and community spread. Multiple procedures performed by otolaryngologists are aerosol-generating procedures (AGPs) and great care should be taken to protect the surgical team before, during, and after these operations.", "doi": "10.1002/alr.22677", "pmid": "32735062", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-07T16:05:56.221Z", "modified": "2021-02-26T08:45:48.857Z"}, {"entity": "publication", "iuid": "afe9178d3e2f40838664abeb888a2a94", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/afe9178d3e2f40838664abeb888a2a94.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/afe9178d3e2f40838664abeb888a2a94"}}, "title": "Intensive care unit admissions for pregnant and nonpregnant women with coronavirus disease 2019.", "authors": [{"family": "Westgren", "given": "Magnus", "initials": "M"}, {"family": "Acharya", "given": "Ganesh", "initials": "G"}], "type": "letter", "published": "2020-11-00", "journal": {"title": "Am J Obstet Gynecol", "issn": "1097-6868", "volume": "223", "issue": "5", "pages": "779-780", "issn-l": null}, "abstract": null, "doi": "10.1016/j.ajog.2020.07.046", "pmid": "32721395", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0002-9378(20)30777-8"}, {"db": "pmc", "key": "PMC7382351"}], "notes": [], "created": "2020-12-07T16:10:21.169Z", "modified": "2020-12-07T16:10:21.192Z"}, {"entity": "publication", "iuid": "e84db98dcc2d4608b3f67826eaa81562", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e84db98dcc2d4608b3f67826eaa81562.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e84db98dcc2d4608b3f67826eaa81562"}}, "title": "In silico drug discovery of major metabolites from spices as SARS-CoV-2 main protease inhibitors.", "authors": [{"family": "Ibrahim", "given": "Mahmoud A A", "initials": "MAA"}, {"family": "Abdelrahman", "given": "Alaa H M", "initials": "AHM"}, {"family": "Hussien", "given": "Taha A", "initials": "TA"}, {"family": "Badr", "given": "Esraa A A", "initials": "EAA"}, {"family": "Mohamed", "given": "Tarik A", "initials": "TA"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}, {"family": "Pare", "given": "Paul W", "initials": "PW"}, {"family": "Efferth", "given": "Thomas", "initials": "T"}, {"family": "Hegazy", "given": "Mohamed-Elamir F", "initials": "MF"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Comput Biol Med", "issn": "1879-0534", "issn-l": null, "volume": "126", "issue": null, "pages": "104046"}, "abstract": "Coronavirus Disease 2019 (COVID-19) is an infectious illness caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), originally identified in Wuhan, China (December 2019) and has since expanded into a pandemic. Here, we investigate metabolites present in several common spices as possible inhibitors of COVID-19. Specifically, 32 compounds isolated from 14 cooking seasonings were examined as inhibitors for SARS-CoV-2 main protease (M pro), which is required for viral multiplication. Using a drug discovery approach to identify possible antiviral leads, in silico molecular docking studies were performed. Docking calculations revealed a high potency of salvianolic acid A and curcumin as Mpro inhibitors with binding energies of -9.7 and -9.2 kcal/mol, respectively. Binding mode analysis demonstrated the ability of salvianolic acid A and curcumin to form nine and six hydrogen bonds, respectively with amino acids proximal to Mpro's active site. Stabilities and binding affinities of the two identified natural spices were calculated over 40 ns molecular dynamics simulations and compared to an antiviral protease inhibitor (lopinavir). Molecular mechanics-generalized Born surface area energy calculations revealed greater salvianolic acid A affinity for the enzyme over curcumin and lopinavir with energies of -44.8, -34.2 and -34.8 kcal/mol, respectively. Using a STRING database, protein-protein interactions were identified for salvianolic acid A included the biochemical signaling genes ACE, MAPK14 and ESR1; and for curcumin, EGFR and TNF. This study establishes salvianolic acid A as an in silico natural product inhibitor against the SARS-CoV-2 main protease and provides a promising inhibitor lead for in vitro enzyme testing.", "doi": "10.1016/j.compbiomed.2020.104046", "pmid": "33065388", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S0010-4825(20)30377-2"}, {"db": "pmc", "key": "PMC7543985"}], "notes": [], "created": "2020-12-01T17:08:08.474Z", "modified": "2021-02-26T08:45:25.924Z"}, {"entity": "publication", "iuid": "fc7c4566185d4cc0bffd118dcbad5cbf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc7c4566185d4cc0bffd118dcbad5cbf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc7c4566185d4cc0bffd118dcbad5cbf"}}, "title": "Impacts of COVID-19 on public transport ridership in Sweden: Analysis of ticket validations, sales and passenger counts.", "authors": [{"family": "Jenelius", "given": "Erik", "initials": "E"}, {"family": "Cebecauer", "given": "Matej", "initials": "M"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Transp Res Interdiscip Perspect", "issn": "2590-1982", "issn-l": null, "volume": "8", "issue": null, "pages": "100242"}, "abstract": "The paper analyses the impacts of COVID-19 on daily public transport ridership in the three most populated regions of Sweden (Stockholm, V\u00e4stra G\u00f6taland and Sk\u00e5ne) during spring 2020. The analysis breaks down the overall ridership with respect to ticket types, youths and seniors, and transport modes based on ticket validations, sales and passenger counts data. By utilizing disaggregate ticket validation data with consistent card ids we further investigate to what extent fewer people travelled, or each person travelled less, during the pandemic. The decrease in public transport ridership (40%-60% across regions) was severe compared with other transport modes. Ridership was not restricted by service levels as supply generally remained unchanged throughout the period. The ridership reduction stems primarily from a lower number of active public transport travellers. Travellers switched from monthly period tickets to single tickets and travel funds, while the use and the sales of short period tickets, used predominantly by tourists, dropped to almost zero. One-year period tickets and school tickets increased from mid-April, which could indicate that the travellers using these tickets are particularly captive to the public transport system. Collaborative effort is required to put the results in the international context.", "doi": "10.1016/j.trip.2020.100242", "pmid": "34173478", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S2590-1982(20)30153-6"}, {"db": "pmc", "key": "PMC7575262"}], "notes": [], "created": "2021-06-28T18:10:46.293Z", "modified": "2022-11-09T08:33:38.780Z"}, {"entity": "publication", "iuid": "9bbc433be67043b186493edb7eae38df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9bbc433be67043b186493edb7eae38df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9bbc433be67043b186493edb7eae38df"}}, "title": "Human recombinant soluble ACE2 in severe COVID-19.", "authors": [{"family": "Zoufaly", "given": "Alexander", "initials": "A"}, {"family": "Poglitsch", "given": "Marko", "initials": "M"}, {"family": "Aberle", "given": "Judith H", "initials": "JH"}, {"family": "Hoepler", "given": "Wolfgang", "initials": "W"}, {"family": "Seitz", "given": "Tamara", "initials": "T"}, {"family": "Traugott", "given": "Marianna", "initials": "M"}, {"family": "Grieb", "given": "Alexander", "initials": "A"}, {"family": "Pawelka", "given": "Erich", "initials": "E"}, {"family": "Laferl", "given": "Hermann", "initials": "H"}, {"family": "Wenisch", "given": "Christoph", "initials": "C"}, {"family": "Neuhold", "given": "Stephanie", "initials": "S"}, {"family": "Haider", "given": "Doris", "initials": "D"}, {"family": "Stiasny", "given": "Karin", "initials": "K"}, {"family": "Bergthaler", "given": "Andreas", "initials": "A"}, {"family": "Puchhammer-Stoeckl", "given": "Elisabeth", "initials": "E"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Montserrat", "given": "Nuria", "initials": "N"}, {"family": "Zhang", "given": "Haibo", "initials": "H"}, {"family": "Slutsky", "given": "Arthur S", "initials": "AS"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}], "type": "case reports", "published": "2020-11-00", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "volume": "8", "issue": "11", "pages": "1154-1158", "issn-l": "2213-2600"}, "abstract": "Case report", "doi": "10.1016/S2213-2600(20)30418-5", "pmid": "33131609", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(20)30418-5"}, {"db": "pmc", "key": "PMC7515587"}], "notes": [], "created": "2020-11-27T10:17:02.154Z", "modified": "2021-01-22T12:06:19.752Z"}, {"entity": "publication", "iuid": "7557f87aee3a4ff6a775af1a300c884c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7557f87aee3a4ff6a775af1a300c884c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7557f87aee3a4ff6a775af1a300c884c"}}, "title": "Fact vs Fallacy: The Anti-Vaccine Discussion Reloaded.", "authors": [{"family": "Stolle", "given": "Lucas B", "initials": "LB"}, {"family": "Nalamasu", "given": "Rohit", "initials": "R"}, {"family": "Pergolizzi", "given": "Joseph V", "initials": "JV"}, {"family": "Varrassi", "given": "Giustino", "initials": "G"}, {"family": "Magnusson", "given": "Peter", "initials": "P"}, {"family": "LeQuang", "given": "JoAnn", "initials": "J"}, {"family": "Breve", "given": "Frank", "initials": "F"}, {"family": "NEMA Research Group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Adv Ther", "issn": "1865-8652", "volume": "37", "issue": "11", "pages": "4481-4490", "issn-l": "0741-238X"}, "abstract": "In the light of the COVID-19 pandemic, anti-vaccine sentiments have been on the rise, with a recent seminal study on the development of anti-vaccine views in social media even making its way into Nature Communications. Yet, with the current scientific consensus being in overwhelming agreement over the safety and efficacy of vaccines, many scientists lose their grasp on the fears, concerns, and arguments that the opposition may hold. This paper discusses and evaluates vaccine-hesitant individuals on a socioeconomic, historical, and philosophical landscape. It also provides an analysis of common argumentative patterns and the psychological impact that these arguments may have on undecided individuals. The discussion also explores why anti-vaccine sentiments are on the rise, and how members of the scientific and medical community require a more structured approach to communicating key arguments. This is particularly important if vaccination rates and herd immunity are to be sustained. No longer is it sufficient to win arguments based on a factual and scientific basis, but rather scientists and medical practitioners have to focus on conveying confidence and reassurance on both an informative and emotional level to those with doubts and fears.", "doi": "10.1007/s12325-020-01502-y", "pmid": "32965654", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s12325-020-01502-y"}, {"db": "pmc", "key": "PMC7509825"}], "notes": [], "created": "2020-11-22T09:53:01.112Z", "modified": "2020-11-22T09:53:01.131Z"}, {"entity": "publication", "iuid": "72403b0041cd47e1bd619539665ce532", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/72403b0041cd47e1bd619539665ce532.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/72403b0041cd47e1bd619539665ce532"}}, "title": "Excess deaths from COVID-19 correlate with age and socio-economic status. A database study in the Stockholm region.", "authors": [{"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "F\u00fcrst", "given": "Per", "initials": "P"}, {"family": "Schultz", "given": "Torbj\u00f6rn", "initials": "T"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "issn-l": "0300-9734", "volume": "125", "issue": "4", "pages": "297-304"}, "abstract": "The COVID-19 pandemic has affected the entire health care system, internationally as well as in Sweden. We aimed to study excess deaths (all death causes, but also COVID-19-related deaths) during the COVID-19 pandemic regarding age, socio-economic status, the situation in nursing homes, and place of death for nursing home residents.\r\n\r\nWe performed a descriptive regional registry data study using VAL, the Stockholm Regional Council's central data warehouse, which covers almost all health care use in the county of Stockholm. T tests and chi-square tests were used for comparisons.\r\n\r\nCompared with 2016-2019, there were excess deaths in March-May 2020 ( p < 0.0001), mainly explained by COVID-19, but in April there were also unexplained excess deaths. Individuals dying from COVID-19 were older than patients dying from other causes (p < 0.0001). There were more patient deaths among people residing in less advantaged socio-economic areas (p < 0.0001). Nursing home residents dying from COVID-19 were more often admitted to acute hospitals than residents dying from other causes (p < 0.0001). Also, the proportion of admissions of nursing home residents dying from other causes increased from April to May 2020 (p < 0.0001).\r\n\r\nDying from COVID-19 mainly affects the elderly, nursing home residents, and persons from less advantaged socio-economic groups. The pandemic has resulted in an increase in acute admissions of dying nursing home residents to acute hospitals.", "doi": "10.1080/03009734.2020.1828513", "pmid": "33100083", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7594844"}], "notes": [], "created": "2020-12-01T15:28:20.193Z", "modified": "2022-11-09T08:34:37.083Z"}, {"entity": "publication", "iuid": "60ce9a3171084603b2c06be19e4deb20", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60ce9a3171084603b2c06be19e4deb20.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60ce9a3171084603b2c06be19e4deb20"}}, "title": "Estimation of global case fatality rate of coronavirus disease 2019 (COVID-19) using meta-analyses: Comparison between calendar date and days since the outbreak of the first confirmed case.", "authors": [{"family": "Ghayda", "given": "Ramy Abou", "initials": "RA"}, {"family": "Lee", "given": "Keum Hwa", "initials": "KH"}, {"family": "Han", "given": "Young Joo", "initials": "YJ"}, {"family": "Ryu", "given": "Seohyun", "initials": "S"}, {"family": "Hong", "given": "Sung Hwi", "initials": "SH"}, {"family": "Yoon", "given": "Sojung", "initials": "S"}, {"family": "Jeong", "given": "Gwang Hun", "initials": "GH"}, {"family": "Lee", "given": "Jinhee", "initials": "J"}, {"family": "Lee", "given": "Jun Young", "initials": "JY"}, {"family": "Yang", "given": "Jae Won", "initials": "JW"}, {"family": "Effenberger", "given": "Maria", "initials": "M"}, {"family": "Eisenhut", "given": "Michael", "initials": "M"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Solmi", "given": "Marco", "initials": "M"}, {"family": "Li", "given": "Han", "initials": "H"}, {"family": "Jacob", "given": "Louis", "initials": "L"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Shin", "given": "Jae Il", "initials": "JI"}, {"family": "Smith", "given": "Lee", "initials": "L"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "volume": "100", "issue": null, "pages": "302-308", "issn-l": "1201-9712"}, "abstract": "Since the outbreak of the coronavirus disease 2019 (COVID-19) in December of 2019 in China, estimating the pandemic's case fatality rate (CFR) has been the focus and interest of many stakeholders. In this manuscript, we prove that the method of using the cumulative CFR is static and does not reflect the trend according to the daily change per unit of time.\n\nA proportion meta-analysis was carried out on the CFR in every country reporting COVID-19 cases. Based on these results, we performed a meta-analysis for a global COVID-19 CFR. Each analysis was performed using two different calculations of CFR: according to the calendar date and according to the days since the outbreak of the first confirmed case. We thus explored an innovative and original calculation of CFR, concurrently based on the date of the first confirmed case as well as on a daily basis.\n\nFor the first time, we showed that using meta-analyses according to the calendar date and days since the outbreak of the first confirmed case, were different.\n\nWe propose that a CFR according to days since the outbreak of the first confirmed case might be a better predictor of the current CFR of COVID-19 and its kinetics.", "doi": "10.1016/j.ijid.2020.08.065", "pmid": "32882434", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(20)30694-9"}, {"db": "pmc", "key": "PMC7462556"}], "notes": [], "created": "2020-12-06T07:31:00.699Z", "modified": "2021-02-26T08:46:13.165Z"}, {"entity": "publication", "iuid": "f1cbe1efc1c1422ca2c02154a1dd7af5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1cbe1efc1c1422ca2c02154a1dd7af5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1cbe1efc1c1422ca2c02154a1dd7af5"}}, "title": "Establishment of a high-dependency unit in Malawi.", "authors": [{"family": "Morton", "given": "Ben", "initials": "B"}, {"family": "Banda", "given": "Ndaziona Peter", "initials": "NP"}, {"family": "Nsomba", "given": "Edna", "initials": "E"}, {"family": "Ngoliwa", "given": "Clara", "initials": "C"}, {"family": "Antoine", "given": "Sandra", "initials": "S"}, {"family": "Gondwe", "given": "Joel", "initials": "J"}, {"family": "Limbani", "given": "Felix", "initials": "F"}, {"family": "Henrion", "given": "Marc Yves Romain", "initials": "MYR"}, {"family": "Chirombo", "given": "James", "initials": "J"}, {"family": "Baker", "given": "Tim", "initials": "T"}, {"family": "Kamalo", "given": "Patrick", "initials": "P"}, {"family": "Phiri", "given": "Chimota", "initials": "C"}, {"family": "Masamba", "given": "Leo", "initials": "L"}, {"family": "Phiri", "given": "Tamara", "initials": "T"}, {"family": "Mallewa", "given": "Jane", "initials": "J"}, {"family": "Mwandumba", "given": "Henry Charles", "initials": "HC"}, {"family": "Mndolo", "given": "Kwazizira Samson", "initials": "KS"}, {"family": "Gordon", "given": "Stephen", "initials": "S"}, {"family": "Rylance", "given": "Jamie", "initials": "J"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "5", "issue": "11", "issn-l": "2059-7908"}, "abstract": "Adults admitted to hospital with critical illness are vulnerable and at high risk of morbidity and mortality, especially in sub-Saharan African settings where resources are severely limited. As life expectancy increases, patient demographics and healthcare needs are increasingly complex and require integrated approaches. Patient outcomes could be improved by increased critical care provision that standardises healthcare delivery, provides specialist staff and enhanced patient monitoring and facilitates some treatment modalities for organ support. In Malawi, we established a new high-dependency unit within Queen Elizabeth Central Hospital, a tertiary referral centre serving the country's Southern region. This unit was designed in partnership with managers, clinicians, nurses and patients to address their needs. In this practice piece, we describe a participatory approach to design and implement a sustainable high-dependency unit for a low-income sub-Saharan African setting. This included: prospective agreement on remit, alignment with existing services, refurbishment of a dedicated physical space, recruitment and training of specialist nurses, development of context-sensitive clinical standard operating procedures, purchase of appropriate and durable equipment and creation of digital clinical information systems. As the global COVID-19 pandemic unfolded, we accelerated unit opening in anticipation of increased clinical requirement and describe how the high-dependency unit responded to this demand.", "doi": "10.1136/bmjgh-2020-004041", "pmid": "33214176", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-004041"}], "notes": [], "created": "2020-11-26T12:32:03.207Z", "modified": "2020-11-26T12:32:03.217Z"}, {"entity": "publication", "iuid": "b0eb6187940d41ffbfe6bc0ce016018e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b0eb6187940d41ffbfe6bc0ce016018e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b0eb6187940d41ffbfe6bc0ce016018e"}}, "title": "Early impact of COVID-19 on individuals with self-reported eating disorders: A survey of ~1,000 individuals in the United States and the Netherlands.", "authors": [{"family": "Termorshuizen", "given": "Jet D", "initials": "JD"}, {"family": "Watson", "given": "Hunna J", "initials": "HJ"}, {"family": "Thornton", "given": "Laura M", "initials": "LM"}, {"family": "Borg", "given": "Stina", "initials": "S"}, {"family": "Flatt", "given": "Rachael E", "initials": "RE"}, {"family": "MacDermod", "given": "Casey M", "initials": "CM"}, {"family": "Harper", "given": "Lauren E", "initials": "LE"}, {"family": "van Furth", "given": "Eric F", "initials": "EF"}, {"family": "Peat", "given": "Christine M", "initials": "CM"}, {"family": "Bulik", "given": "Cynthia M", "initials": "CM"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Int J Eat Disord", "issn": "1098-108X", "issn-l": null, "volume": "53", "issue": "11", "pages": "1780-1790"}, "abstract": "We evaluated the early impact of COVID-19 on people with self-reported eating disorders.\r\n\r\nParticipants in the United States (US, N = 511) and the Netherlands (NL, N = 510), recruited through ongoing studies and social media, completed an online survey that included both quantitative measures and free-text responses assessing the impact of COVID-19 on situational circumstances, eating disorder symptoms, eating disorder treatment, and general well-being.\r\n\r\nResults revealed strong and wide-ranging effects on eating disorder concerns and illness behaviors that were consistent with eating disorder type. Participants with anorexia nervosa (US 62% of sample; NL 69%) reported increased restriction and fears about being able to find foods consistent with their meal plan. Individuals with bulimia nervosa and binge-eating disorder (US 30% of sample; NL 15%) reported increases in their binge-eating episodes and urges to binge. Respondents noted marked increases in anxiety since 2019 and reported greater concerns about the impact of COVID-19 on their mental health than physical health. Although many participants acknowledged and appreciated the transition to telehealth, limitations of this treatment modality for this population were raised. Individuals with past histories of eating disorders noted concerns about relapse related to COVID-19 circumstances. Encouragingly, respondents also noted positive effects including greater connection with family, more time for self-care, and motivation to recover.\r\n\r\nCOVID-19 is associated with increased anxiety and poses specific disorder-related challenges for individuals with eating disorders that require attention by healthcare professionals and carers.", "doi": "10.1002/eat.23353", "pmid": "32720399", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-07T16:11:16.707Z", "modified": "2022-11-09T08:36:27.009Z"}, {"entity": "publication", "iuid": "9bfe22c6f8c743c580a6feed3b78f8eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9bfe22c6f8c743c580a6feed3b78f8eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9bfe22c6f8c743c580a6feed3b78f8eb"}}, "title": "Do point-of-care tests (POCTs) offer a new paradigm for the management of patients with influenza?", "authors": [{"family": "Dickson", "given": "Elizabeth M", "initials": "EM"}, {"family": "Zambon", "given": "Maria", "initials": "M"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "de Lusignan", "given": "Simon", "initials": "S"}, {"family": "Elliot", "given": "Alex J", "initials": "AJ"}, {"family": "Ellis", "given": "Joanna", "initials": "J"}, {"family": "Lackenby", "given": "Angie", "initials": "A"}, {"family": "Smith", "given": "Gillian", "initials": "G"}, {"family": "McMenamin", "given": "Jim", "initials": "J"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "44", "issn-l": null}, "abstract": "The introduction of point-of-care tests (POCTs) has presented new opportunities for the management of patients presenting to healthcare providers with acute respiratory symptoms. This Perspective article is based on the experiences of national infection teams/those managing acute respiratory infections across the United Kingdom in terms of the challenges and opportunities that this may present for public health. This Perspective article was conceived and written pre-coronavirus disease (COVID-19), however the principles we outline here for influenza can also be translated to COVID-19 and some key points are made throughout the article. The greatest challenge for intergrating POCTs into non-traditional environments is the capture of data and samples for surveillance purposes which provides information for public health action. However, POCTs together with measures outlined in this article, offer a new paradigm for the management and public health surveillance of patients with influenza.", "doi": "10.2807/1560-7917.ES.2020.25.44.1900420", "pmid": "33153522", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7645971"}], "notes": [], "created": "2020-12-01T14:46:59.334Z", "modified": "2020-12-01T14:46:59.344Z"}, {"entity": "publication", "iuid": "83ed1f8cf17b401996eda78f45153f36", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/83ed1f8cf17b401996eda78f45153f36.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/83ed1f8cf17b401996eda78f45153f36"}}, "title": "Did location-based games motivate players to socialize during COVID-19?", "authors": [{"family": "Laato", "given": "Samuli", "initials": "S"}, {"family": "Islam", "given": "A K M Najmul", "initials": "AKMN"}, {"family": "Laine", "given": "Teemu H", "initials": "TH"}], "type": "journal-article", "published": "2020-11-00", "journal": {"title": "Telematics and Informatics", "issn": "0736-5853", "issn-l": null, "volume": "54", "issue": null, "pages": "101458"}, "abstract": null, "doi": "10.1016/j.tele.2020.101458", "pmid": null, "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:54:26.640Z", "modified": "2022-11-09T08:38:07.029Z"}, {"entity": "publication", "iuid": "7509e78a75f94b1283539b1fe33942d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7509e78a75f94b1283539b1fe33942d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7509e78a75f94b1283539b1fe33942d7"}}, "title": "Covid-19 in kidney transplant recipients: a systematic review of the case series available three months into the pandemic.", "authors": [{"family": "Oltean", "given": "Mihai", "initials": "M"}, {"family": "S\u00f8fteland", "given": "John Mackay", "initials": "JM"}, {"family": "Bagge", "given": "Jasmine", "initials": "J"}, {"family": "Ekelund", "given": "Jan", "initials": "J"}, {"family": "Felldin", "given": "Marie", "initials": "M"}, {"family": "Schult", "given": "Andreas", "initials": "A"}, {"family": "Magnusson", "given": "Jesper", "initials": "J"}, {"family": "Friman", "given": "Vanda", "initials": "V"}, {"family": "Karason", "given": "Kristjan", "initials": "K"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "volume": "52", "issue": "11", "pages": "830-837", "issn-l": "2374-4235"}, "abstract": "Coronavirus disease 2019 (COVID-19) ranges from a mild illness to acute respiratory distress syndrome (ARDS), multiorgan dysfunction, and death. Transplant recipients are vulnerable due to comorbidities and immunosuppressants that render them susceptible to infections. The information on COVID-19 in kidney transplant recipients remains limited to small case series.\n\nA systematic literature search was conducted, and 12 case series totalling 204 kidney transplant recipients with COVID-19 were identified. Data were extracted, pooled and analysed.\n\nMost patients (74%) were men. The most frequent symptoms were fever (76%), cough (64%) and dyspnoea (43%). At admission, over 70% of the patients had abnormal radiological findings. Leukocyte counts were in the lower normal range. C-reactive protein, ferritin, and D-dimer were consistently increased. Treatments included lowering immunosuppression, hydroxychloroquine, antivirals, tocilizumab and intravenous immunoglobulins. Thirty-one percent of the patients were admitted to intensive care units (ICUs), and 16% required intubation. The overall mortality was 21.2%. Patients who died were significantly older than those who survived (61 \u00b1 12 vs. 51 \u00b1 15, p < .01). Logistic regression revealed that the odds for death increased by 4.3% for each additional year of age (odds ratio [OR] 1.043, 95% confidence interval [CI] 1.005-1.083, p value = .0265).\n\nNo substantial conclusions could be drawn on the efficacy of any particular treatment. More rigorous patient stratification is needed when analysing and reporting data to facilitate future meta-analyses.", "doi": "10.1080/23744235.2020.1792977", "pmid": "32657186", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-30T08:51:24.300Z", "modified": "2020-12-08T14:14:19.150Z"}, {"entity": "publication", "iuid": "a3e7cb41d6e1464a9318407386ba4762", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3e7cb41d6e1464a9318407386ba4762.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3e7cb41d6e1464a9318407386ba4762"}}, "title": "Converging pathways in pulmonary fibrosis and Covid-19 - The fibrotic link to disease severity.", "authors": [{"family": "Wig\u00e9n", "given": "Jenny", "initials": "J"}, {"family": "L\u00f6fdahl", "given": "Anna", "initials": "A"}, {"family": "Bjermer", "given": "Leif", "initials": "L"}, {"family": "Elowsson-Rendin", "given": "Linda", "initials": "L"}, {"family": "Westergren-Thorsson", "given": "Gunilla", "initials": "G"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Respir Med X", "issn": "2590-1435", "volume": "2", "issue": null, "pages": "100023", "issn-l": "2590-1435"}, "abstract": "As Covid-19 affects millions of people worldwide, the global health care will encounter an increasing burden of the aftermaths of the disease. Evidence shows that up to a fifth of the patients develop fibrotic tissue in the lung. The SARS outbreak in the early 2000 resulted in chronic pulmonary fibrosis in a subset (around 4%) of the patients, and correlated to reduced lung function and forced expiratory volume (FEV). The similarities between corona virus infections causing SARS and Covid-19 are striking, except that the novel coronavirus, SARS-CoV-2, has proven to have an even higher communicability. This would translate into a large number of patients seeking care for clinical signs of pulmonary fibrosis, given that the Covid-19 pandemic has up till now (Sept 2020) affected around 30 million people. The SARS-CoV-2 is dependent on binding to the angiotensin converting enzyme 2 (ACE2), which is part of the renin-angiotensin system (RAS). Downregulation of ACE2 upon virus binding disturbs downstream activities of RAS resulting in increased inflammation and development of fibrosis. The poor prognosis and risk of developing pulmonary fibrosis are therefore associated with the increased expression of ACE2 in risk groups, such as obesity, heart disorders and aging, conferring plenty of binding opportunity for the virus and subsequently the internalization of ACE2, thus devoiding the enzyme from acting counter-inflammatory and antifibrotic. Identifying pathways that are associated with Covid-19 severity that result in pulmonary fibrosis may enable early diagnosis and individualized treatment for these patients to prevent or reduce irreversible fibrotic damage to the lung.", "doi": "10.1016/j.yrmex.2020.100023", "pmid": "33083782", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2590-1435(20)30010-5"}, {"db": "pmc", "key": "PMC7546672"}], "notes": [], "created": "2020-11-27T11:49:56.303Z", "modified": "2020-11-27T11:49:56.325Z"}, {"entity": "publication", "iuid": "6444d78ee37f4160adc32e3a9816b527", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6444d78ee37f4160adc32e3a9816b527.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6444d78ee37f4160adc32e3a9816b527"}}, "title": "Considerations on biologicals for patients with allergic disease in times of the COVID-19 pandemic: An EAACI statement.", "authors": [{"family": "Vultaggio", "given": "Alessandra", "initials": "A"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Akdis", "given": "Cezmi A", "initials": "CA"}, {"family": "Akdis", "given": "Mubeccel", "initials": "M"}, {"family": "Bavbek", "given": "Sevim", "initials": "S"}, {"family": "Bossios", "given": "Apostolos", "initials": "A"}, {"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Boyman", "given": "Onur", "initials": "O"}, {"family": "Chaker", "given": "Adam M", "initials": "AM"}, {"family": "Chan", "given": "Susan", "initials": "S"}, {"family": "Chatzipetrou", "given": "Alexia", "initials": "A"}, {"family": "Feleszko", "given": "Wojciech", "initials": "W"}, {"family": "Firinu", "given": "Davide", "initials": "D"}, {"family": "Jutel", "given": "Marek", "initials": "M"}, {"family": "Kauppi", "given": "Paula", "initials": "P"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Kolios", "given": "Antonios", "initials": "A"}, {"family": "Kothari", "given": "Akash", "initials": "A"}, {"family": "Kowalski", "given": "Marek L", "initials": "ML"}, {"family": "Matucci", "given": "Andrea", "initials": "A"}, {"family": "Palomares", "given": "Oscar", "initials": "O"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Rogala", "given": "Barbara", "initials": "B"}, {"family": "Untersmayr", "given": "Eva", "initials": "E"}, {"family": "Eiwegger", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Allergy", "issn": "1398-9995", "issn-l": "0105-4538", "volume": "75", "issue": "11", "pages": "2764-2774"}, "abstract": "The outbreak of the SARS-CoV-2-induced coronavirus disease 2019 (COVID-19) pandemic re-shaped doctor-patient interaction and challenged capacities of healthcare systems. It created many issues around the optimal and safest way to treat complex patients with severe allergic disease. A significant number of the patients are on treatment with biologicals, and clinicians face the challenge to provide optimal care during the pandemic. Uncertainty of the potential risks for these patients is related to the fact that the exact sequence of immunological events during SARS-CoV-2 is not known. Severe COVID-19 patients may experience a \"cytokine storm\" and associated organ damage characterized by an exaggerated release of pro-inflammatory type 1 and type 3 cytokines. These inflammatory responses are potentially counteracted by anti-inflammatory cytokines and type 2 responses. This expert-based EAACI statement aims to provide guidance on the application of biologicals targeting type 2 inflammation in patients with allergic disease. Currently, there is very little evidence for an enhanced risk of patients with allergic diseases to develop severe COVID-19. Studies focusing on severe allergic phenotypes are lacking. At present, noninfected patients on biologicals for the treatment of asthma, atopic dermatitis, chronic rhinosinusitis with nasal polyps, or chronic spontaneous urticaria should continue their biologicals targeting type 2 inflammation via self-application. In case of an active SARS-CoV-2 infection, biological treatment needs to be stopped until clinical recovery and SARS-CoV-2 negativity is established and treatment with biologicals should be re-initiated. Maintenance of add-on therapy and a constant assessment of disease control, apart from acute management, are demanded.", "doi": "10.1111/all.14407", "pmid": "32500526", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7300800"}], "notes": [], "created": "2020-12-09T10:37:02.018Z", "modified": "2020-12-11T12:45:39.347Z"}, {"entity": "publication", "iuid": "c16a784427d3471e850b91eee6e6a91d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c16a784427d3471e850b91eee6e6a91d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c16a784427d3471e850b91eee6e6a91d"}}, "title": "Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy.", "authors": [{"family": "Mastellos", "given": "Dimitrios C", "initials": "DC"}, {"family": "Pires da Silva", "given": "Bruno G P", "initials": "BGP"}, {"family": "Fonseca", "given": "Benedito A L", "initials": "BAL"}, {"family": "Fonseca", "given": "Natasha P", "initials": "NP"}, {"family": "Auxiliadora-Martins", "given": "Maria", "initials": "M"}, {"family": "Mastaglio", "given": "Sara", "initials": "S"}, {"family": "Ruggeri", "given": "Annalisa", "initials": "A"}, {"family": "Sironi", "given": "Marina", "initials": "M"}, {"family": "Radermacher", "given": "Peter", "initials": "P"}, {"family": "Chrysanthopoulou", "given": "Akrivi", "initials": "A"}, {"family": "Skendros", "given": "Panagiotis", "initials": "P"}, {"family": "Ritis", "given": "Konstantinos", "initials": "K"}, {"family": "Manfra", "given": "Ilenia", "initials": "I"}, {"family": "Iacobelli", "given": "Simona", "initials": "S"}, {"family": "Huber-Lang", "given": "Markus", "initials": "M"}, {"family": "Nilsson", "given": "Bo", "initials": "B"}, {"family": "Yancopoulou", "given": "Despina", "initials": "D"}, {"family": "Connolly", "given": "E Sander", "initials": "ES"}, {"family": "Garlanda", "given": "Cecilia", "initials": "C"}, {"family": "Ciceri", "given": "Fabio", "initials": "F"}, {"family": "Risitano", "given": "Antonio M", "initials": "AM"}, {"family": "Calado", "given": "Rodrigo T", "initials": "RT"}, {"family": "Lambris", "given": "John D", "initials": "JD"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Clin Immunol", "issn": "1521-7035", "issn-l": "1521-6616", "volume": "220", "issue": null, "pages": "108598"}, "abstract": "Growing clinical evidence has implicated complement as a pivotal driver of COVID-19 immunopathology. Deregulated complement activation may fuel cytokine-driven hyper-inflammation, thrombotic microangiopathy and NET-driven immunothrombosis, thereby leading to multi-organ failure. Complement therapeutics have gained traction as candidate drugs for countering the detrimental consequences of SARS-CoV-2 infection. Whether blockade of terminal complement effectors (C5, C5a, or C5aR1) may elicit similar outcomes to upstream intervention at the level of C3 remains debated. Here we compare the efficacy of the C5-targeting monoclonal antibody eculizumab with that of the compstatin-based C3-targeted drug candidate AMY-101 in small independent cohorts of severe COVID-19 patients. Our exploratory study indicates that therapeutic complement inhibition abrogates COVID-19 hyper-inflammation. Both C3 and C5 inhibitors elicit a robust anti-inflammatory response, reflected by a steep decline in C-reactive protein and IL-6 levels, marked lung function improvement, and resolution of SARS-CoV-2-associated acute respiratory distress syndrome (ARDS). C3 inhibition afforded broader therapeutic control in COVID-19 patients by attenuating both C3a and sC5b-9 generation and preventing FB consumption. This broader inhibitory profile was associated with a more robust decline of neutrophil counts, attenuated neutrophil extracellular trap (NET) release, faster serum LDH decline, and more prominent lymphocyte recovery. These early clinical results offer important insights into the differential mechanistic basis and underlying biology of C3 and C5 inhibition in COVID-19 and point to a broader pathogenic involvement of C3-mediated pathways in thromboinflammation. They also support the evaluation of these complement-targeting agents as COVID-19 therapeutics in large prospective trials.", "doi": "10.1016/j.clim.2020.108598", "pmid": "32961333", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1521-6616(20)30758-0"}, {"db": "pmc", "key": "PMC7501834"}, {"db": "mid", "key": "NIHMS1630767"}], "notes": [], "created": "2020-11-22T09:51:36.660Z", "modified": "2021-02-26T08:45:48.658Z"}, {"entity": "publication", "iuid": "7618b0b3be3a4654afdfe602c1f37d89", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7618b0b3be3a4654afdfe602c1f37d89.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7618b0b3be3a4654afdfe602c1f37d89"}}, "title": "Cell-based therapies for coronavirus disease 2019: proper clinical investigations are essential.", "authors": [{"family": "Khoury", "given": "Maroun", "initials": "M"}, {"family": "Rocco", "given": "Patricia R M", "initials": "PRM"}, {"family": "Phinney", "given": "Donald G", "initials": "DG"}, {"family": "Krampera", "given": "Mauro", "initials": "M"}, {"family": "Martin", "given": "Ivan", "initials": "I"}, {"family": "Viswanathan", "given": "Sowmya", "initials": "S"}, {"family": "Nolta", "given": "Jan A", "initials": "JA"}, {"family": "LeBlanc", "given": "Katarina", "initials": "K"}, {"family": "Galipeau", "given": "Jacques", "initials": "J"}, {"family": "Weiss", "given": "Daniel J", "initials": "DJ"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Cytotherapy", "issn": "1477-2566", "volume": "22", "issue": "11", "pages": "602-605", "issn-l": "1465-3249"}, "abstract": "The serious consequences of the global coronavirus disease 2019 (COVID-19) pandemic have prompted a rapid global response to develop effective therapies that can lessen disease severity in infected patients. Cell-based approaches, primarily using mesenchymal stromal cells (MSCs), have demonstrated a strong safety profile and possible efficacy in patients with acute respiratory distress syndrome (ARDS), but whether these therapies are effective for treating respiratory virus-induced ARDS is unknown. According to the World Health Organization International Clinical Trials Registry Platform and the National Institutes of Health ClinicalTrials.gov databases, 27 clinical investigations of MSC-based cell therapy approaches have begun in China since the onset of the COVID-19 outbreak, with a growing number of academic and industry trials elsewhere as well. Several recent published reports have suggested potential efficacy; however, the available data presented are either anecdotal or from incomplete, poorly controlled investigations. Therefore, although there may be a potential role for MSCs and other cell-based therapies in treatment of COVID-19, these need to be investigated in a rationally designed, controlled approach if safety and efficacy are to be demonstrated accurately. The authors urge that the field proceed by finding a balance between swift experimentation and communication of results and scientifically coherent generation and analysis of clinical data.", "doi": "10.1016/j.jcyt.2020.04.089", "pmid": "32933835", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1465-3249(20)30616-2"}, {"db": "pmc", "key": "PMC7163352"}], "notes": [], "created": "2020-11-26T12:31:43.302Z", "modified": "2020-12-03T15:32:34.772Z"}, {"entity": "publication", "iuid": "ef5fe45bee7c4605946def64196f45a3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef5fe45bee7c4605946def64196f45a3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef5fe45bee7c4605946def64196f45a3"}}, "title": "Can hyperbaric oxygen safely serve as an anti-inflammatory treatment for COVID-19?", "authors": [{"family": "Kjellberg", "given": "Anders", "initials": "A"}, {"family": "De Maio", "given": "Antonio", "initials": "A"}, {"family": "Lindholm", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Med Hypotheses", "issn": "1532-2777", "volume": "144", "issue": null, "pages": "110224", "issn-l": null}, "abstract": "SARS-CoV-2 affects part of the innate immune response and activates an inflammatory cascade stimulating the release of cytokines and chemokines, particularly within the lung. Indeed, the inflammatory response during COVID-19 is likely the cause for the development of acute respiratory distress syndrome (ARDS). Patients with mild symptoms also show significant changes on pulmonary CT-scan suggestive of severe inflammatory involvement.\n\nThe overall hypothesis is that HBO 2 is safe and reduces the inflammatory response in COVID-19 pneumonitis by attenuation of the innate immune system, increase hypoxia tolerance and thereby prevent organ failure and reduce mortality.\n\nHBO 2 is used in clinical practice to treat inflammatory conditions but has not been scientifically evaluated for COVID-19. Experimental and empirical data suggests that HBO2 may reduce inflammatory response in COVID-19. However, there are concerns regarding pulmonary safety in patients with pre-existing viral pneumonitis.\n\nAnecdotes from \"compassionate use\" and two published case reports show promising results.\n\nSmall prospective clinical trials are on the way and we are conducting a randomized clinical trial.", "doi": "10.1016/j.mehy.2020.110224", "pmid": "33254531", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0306-9877(20)31444-4"}], "notes": [], "created": "2020-12-03T08:22:26.149Z", "modified": "2020-12-03T08:23:38.944Z"}, {"entity": "publication", "iuid": "2ed302c1d9094ee7a8728af4c143f3f6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ed302c1d9094ee7a8728af4c143f3f6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ed302c1d9094ee7a8728af4c143f3f6"}}, "title": "COVID-19: risk accumulation among biologically and socially vulnerable older populations.", "authors": [{"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A"}, {"family": "Dekhtyar", "given": "Serhiy", "initials": "S"}, {"family": "Vetrano", "given": "Davide L", "initials": "DL"}, {"family": "Bellander", "given": "Tom", "initials": "T"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Ageing Res Rev", "issn": "1872-9649", "issn-l": "1568-1637", "volume": "63", "issue": null, "pages": "101149"}, "abstract": "Emerging data show that the health and economic impacts of COVID-19 are being disproportionately borne by individuals who are not only biologically, but also socially vulnerable. Based on preliminary data from Sweden and other reports, in this paper we propose a conceptual framework whereby different factors related to biological and social vulnerability may explain the specific COVID-19 burden among older people. There is already some evidence showing large social disparities in the prevention, treatment, prognosis and/or long-term consequences of COVID-19. The remaining question is to what extent these affect older adults specifically. We provide the rationale to address this question with scientific methods and proper study designs, where the interplay between individuals' biomedical status and their social environment is the focus. Only through interdisciplinary research integrating biological, clinical and social data will we be able to provide new insights into the SARS-CoV-2 pandemic and inform actions aimed at reducing older adults' vulnerability to COVID-19 or other similar pandemics in the future.", "doi": "10.1016/j.arr.2020.101149", "pmid": "32818650", "labels": {"Type: Journal article": null, "Topics: Register-based research": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7430278"}, {"db": "pii", "key": "S1568-1637(20)30284-1"}], "notes": [], "created": "2020-11-26T12:20:00.368Z", "modified": "2023-06-19T15:29:09.387Z"}, {"entity": "publication", "iuid": "e3eaabbfa0ec451b8202ccdb29c1d375", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3eaabbfa0ec451b8202ccdb29c1d375.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3eaabbfa0ec451b8202ccdb29c1d375"}}, "title": "COVID-19: minimising contaminated aerosol spreading during CPAP treatment.", "authors": [{"family": "Donaldsson", "given": "Snorri", "initials": "S"}, {"family": "Naver", "given": "Lars", "initials": "L"}, {"family": "Jonsson", "given": "Baldvin", "initials": "B"}, {"family": "Drevhammar", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Arch Dis Child Fetal Neonatal Ed", "issn": "1468-2052", "issn-l": null, "volume": "105", "issue": "6", "pages": "669-671"}, "abstract": "The COVID-19 pandemic has raised concern for healthcare workers getting infected via aerosol from non-invasive respiratory support of infants. Attaching filters that remove viral particles in air from the expiratory limb of continuous positive airway pressure (CPAP) devices should theoretically decrease the risk. However, adding filters to the expiratory limb could add to expiratory resistance and thereby increase the imposed work of breathing (WOB).\r\n\r\nTo evaluate the effects on imposed WOB when attaching filters to the expiratory limb of CPAP devices.\r\n\r\nTwo filters were tested on three CPAP systems at two levels of CPAP in a mechanical lung model. Main outcome was imposed WOB.\r\n\r\nThere was a minor increase in imposed WOB when attaching the filters. The differences between the two filters were small.\r\n\r\nTo minimise contaminated aerosol generation during CPAP treatment, filters can be attached to expiratory tubing with only a minimal increase in imposed WOB in a non-humidified environment. Care has to be taken to avoid filter obstruction and replace filters as recommended.", "doi": "10.1136/archdischild-2020-319431", "pmid": "32669360", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "archdischild-2020-319431"}], "notes": [], "created": "2020-12-07T16:37:43.317Z", "modified": "2021-02-26T08:46:13.555Z"}, {"entity": "publication", "iuid": "7b7fc3cac0ab460f8c23c8110677303f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b7fc3cac0ab460f8c23c8110677303f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b7fc3cac0ab460f8c23c8110677303f"}}, "title": "COVID-19: The immediate response of european academic dental institutions and future implications for dental education.", "authors": [{"family": "Quinn", "given": "Barry", "initials": "B"}, {"family": "Field", "given": "James", "initials": "J"}, {"family": "Gorter", "given": "Ronald", "initials": "R"}, {"family": "Akota", "given": "Ilze", "initials": "I"}, {"family": "Manzanares", "given": "Maria-Cristina", "initials": "MC"}, {"family": "Paganelli", "given": "Corrado", "initials": "C"}, {"family": "Davies", "given": "Julia", "initials": "J"}, {"family": "Dixon", "given": "Jonathan", "initials": "J"}, {"family": "Gabor", "given": "Gerber", "initials": "G"}, {"family": "Amaral Mendes", "given": "Rui", "initials": "R"}, {"family": "Hahn", "given": "Petra", "initials": "P"}, {"family": "Vital", "given": "Sibylle", "initials": "S"}, {"family": "O'Brien", "given": "Judith", "initials": "J"}, {"family": "Murphy", "given": "Denis", "initials": "D"}, {"family": "Tubert-Jeannin", "given": "St\u00e9phanie", "initials": "S"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Eur J Dent Educ", "issn": "1600-0579", "volume": "24", "issue": "4", "pages": "811-814", "issn-l": null}, "abstract": "The COVID-19 pandemic has had an immediate and dramatic impact on dental education. The Association of Dental Education in Europe decided to carry out an investigation to assess the immediate response of European Academic Dental Institutions. An online survey was sent to both member and non-member dental schools to investigate the impact on non-clinical and clinical education, assessment and the well-being/pastoral care measures implemented. The preliminary findings and discussion are presented in this paper, for the responses collected between the 25 March and 5 April 2020. The survey at this time of publication is ongoing, and detailed results can be accessed https://adee.org/covid-19-european-dental-education%E2%80%99s-immediate-response.", "doi": "10.1111/eje.12542", "pmid": "32394605", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7272881"}], "notes": [], "created": "2020-12-10T08:39:33.398Z", "modified": "2021-02-26T08:45:48.363Z"}, {"entity": "publication", "iuid": "c7b5d0c782d34b6b8e7f92788ee11cde", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7b5d0c782d34b6b8e7f92788ee11cde.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7b5d0c782d34b6b8e7f92788ee11cde"}}, "title": "COVID-19 puts the Sustainable Development Goals center stage.", "authors": [{"family": "Ottersen", "given": "Ole Petter", "initials": "OP"}, {"family": "Engebretsen", "given": "Eivind", "initials": "E"}], "type": "letter", "published": "2020-11-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956", "volume": "26", "issue": "11", "pages": "1672-1673"}, "abstract": "Correspondence", "doi": "10.1038/s41591-020-1094-y", "pmid": "33037423", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-020-1094-y"}], "notes": [], "created": "2020-12-01T17:24:14.636Z", "modified": "2020-12-01T17:24:43.108Z"}, {"entity": "publication", "iuid": "ed9e198eee0a4b77a10da7df00a85602", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed9e198eee0a4b77a10da7df00a85602.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed9e198eee0a4b77a10da7df00a85602"}}, "title": "Age, Frailty, and Comorbidity as Prognostic Factors for Short-Term Outcomes in Patients With Coronavirus Disease 2019 in Geriatric Care.", "authors": [{"family": "H\u00e4gg", "given": "Sara", "initials": "S"}, {"family": "Jylh\u00e4v\u00e4", "given": "Juulia", "initials": "J"}, {"family": "Wang", "given": "Yunzhang", "initials": "Y"}, {"family": "Xu", "given": "Hong", "initials": "H"}, {"family": "Metzner", "given": "Carina", "initials": "C"}, {"family": "Annetorp", "given": "Martin", "initials": "M"}, {"family": "Garcia-Ptacek", "given": "Sara", "initials": "S"}, {"family": "Khedri", "given": "Masih", "initials": "M"}, {"family": "Bostr\u00f6m", "given": "Anne-Marie", "initials": "A"}, {"family": "Kadir", "given": "Ahmadul", "initials": "A"}, {"family": "Johansson", "given": "Anna", "initials": "A"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}, {"family": "Cederholm", "given": "Tommy", "initials": "T"}, {"family": "Religa", "given": "Dorota", "initials": "D"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "J Am Med Dir Assoc", "issn": "1538-9375", "issn-l": null, "volume": "21", "issue": "11", "pages": "1555-1559.e2"}, "abstract": "To analyze whether frailty and comorbidities are associated with in-hospital mortality and discharge to home in older adults hospitalized for coronavirus disease 2019 (COVID-19).\r\n\r\nSingle-center observational study.\r\n\r\nPatients admitted to geriatric care in a large hospital in Sweden between March 1 and June 11, 2020; 250 were treated for COVID-19 and 717 for other diagnoses.\r\n\r\nCOVID-19 diagnosis was clinically confirmed by positive reverse transcription polymerase chain reaction test or, if negative, by other methods. Patient data were extracted from electronic medical records, which included Clinical Frailty Scale (CFS), and were further used for assessments of the Hospital Frailty Risk Score (HFRS) and the Charlson Comorbidity Index (CCI). In-hospital mortality and home discharge were followed up for up to 25 and 28 days, respectively. Multivariate Cox regression models adjusted for age and sex were used.\r\n\r\nAmong the patients with COVID-19, in-hospital mortality rate was 24% and home discharge rate was 44%. Higher age was associated with in-hospital mortality (hazard ratio [HR] 1.05 per each year, 95% confidence interval [CI] 1.01\u20121.08) and lower probability of home discharge (HR 0.97, 95% CI 0.95\u20120.99). CFS (>5) and CCI, but not HFRS, were predictive of in-hospital mortality (HR 1.93, 95% CI 1.02\u20123.65 and HR 1.27, 95% CI 1.02\u20121.58, respectively). Patients with CFS >5 had a lower probability of being discharged home (HR 0.38, 95% CI 0.25\u20120.58). CCI and HFRS were not associated with home discharge. In general, effects were more pronounced in men. Acute kidney injury was associated with in-hospital mortality and hypertension with discharge to home. Other comorbidities (diabetes, cardiovascular disease, lung diseases, chronic kidney disease and dementia) were not associated with either outcome.\r\n\r\nOf all geriatric patients with COVID-19, 3 out of 4 survived during the study period. Our results indicate that in addition to age, the level of frailty is a useful predictor of short-term COVID-19 outcomes in geriatric patients.", "doi": "10.1016/j.jamda.2020.08.014", "pmid": "32978065", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S1525-8610(20)30704-0"}, {"db": "pmc", "key": "PMC7427570"}], "notes": [], "created": "2020-12-03T09:52:18.204Z", "modified": "2022-11-09T08:39:52.158Z"}, {"entity": "publication", "iuid": "7628ba6a3c0448c6a81d8b7127f04490", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7628ba6a3c0448c6a81d8b7127f04490.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7628ba6a3c0448c6a81d8b7127f04490"}}, "title": "Addressing Influenza Vaccination in MENA Region during the COVID-19 Pandemic: Decreasing the Effects of the Collision.", "authors": [{"family": "Al Awaidy", "given": "Salah T", "initials": "ST"}, {"family": "Uyaro\u011flu", "given": "O\u011fuz Abdullah", "initials": "OA"}, {"family": "Wannous", "given": "Chadia", "initials": "C"}, {"family": "Tanriover", "given": "Mine Durusu", "initials": "MD"}], "type": "editorial", "published": "2020-11-00", "journal": {"title": "Oman Med J", "issn": "1999-768X", "volume": "35", "issue": "6", "pages": "e200", "issn-l": null}, "abstract": "Editorial", "doi": "10.5001/omj.2020.132", "pmid": "33214914", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "OMJ-35-06-2000198"}, {"db": "pmc", "key": "PMC7653348"}], "notes": [], "created": "2020-11-27T10:42:01.106Z", "modified": "2020-11-27T10:42:29.251Z"}, {"entity": "publication", "iuid": "831466582e8c428088cfc333e39ab798", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/831466582e8c428088cfc333e39ab798.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/831466582e8c428088cfc333e39ab798"}}, "title": "Adapting care for older cancer patients during the COVID-19 pandemic: Recommendations from the International Society of Geriatric Oncology (SIOG) COVID-19 Working Group.", "authors": [{"family": "Battisti", "given": "Nicol\u00f2 Matteo Luca", "initials": "NML"}, {"family": "Mislang", "given": "Anna Rachelle", "initials": "AR"}, {"family": "Cooper", "given": "Lisa", "initials": "L"}, {"family": "O'Donovan", "given": "Anita", "initials": "A"}, {"family": "Audisio", "given": "Riccardo A", "initials": "RA"}, {"family": "Cheung", "given": "Kwok-Leung", "initials": "KL"}, {"family": "Sarri\u00f3", "given": "Regina Giron\u00e9s", "initials": "RG"}, {"family": "Stauder", "given": "Reinhard", "initials": "R"}, {"family": "Soto-Perez-de-Celis", "given": "Enrique", "initials": "E"}, {"family": "Jaklitsch", "given": "Michael", "initials": "M"}, {"family": "Williams", "given": "Grant R", "initials": "GR"}, {"family": "O'Hanlon", "given": "Shane", "initials": "S"}, {"family": "Alam", "given": "Mahmood", "initials": "M"}, {"family": "Cairo", "given": "Clarito", "initials": "C"}, {"family": "Colloca", "given": "Giuseppe", "initials": "G"}, {"family": "Gil", "given": "Luiz Antonio", "initials": "LA"}, {"family": "Sattar", "given": "Schroder", "initials": "S"}, {"family": "Kantilal", "given": "Kumud", "initials": "K"}, {"family": "Russo", "given": "Chiara", "initials": "C"}, {"family": "Lichtman", "given": "Stuart M", "initials": "SM"}, {"family": "Brain", "given": "Etienne", "initials": "E"}, {"family": "Kanesvaran", "given": "Ravindran", "initials": "R"}, {"family": "Wildiers", "given": "Hans", "initials": "H"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "J Geriatr Oncol", "issn": "1879-4076", "volume": "11", "issue": "8", "pages": "1190-1198", "issn-l": null}, "abstract": "The COVID-19 pandemic poses a barrier to equal and evidence-based management of cancer in older adults. The International Society of Geriatric Oncology (SIOG) formed a panel of experts to develop consensus recommendations on the implications of the pandemic on several aspects of cancer care in this age group including geriatric assessment (GA), surgery, radiotherapy, systemic treatment, palliative care and research. Age and cancer diagnosis are significant predictors of adverse outcomes of the COVID-19 infection. In this setting, GA is particularly valuable to drive decision-making. GA may aid estimating physiologic reserve and adaptive capability, assessing risk-benefits of either providing or temporarily withholding treatments, and determining patient preferences to help inform treatment decisions. In a resource-constrained setting, geriatric screening tools may be administered remotely to identify patients requiring comprehensive GA. Tele-health is also crucial to ensure adequate continuity of care and minimize the risk of infection exposure. In general, therapeutic decisions should favor the most effective and least invasive approach with the lowest risk of adverse outcomes. In selected cases, this might require deferring or omitting surgery, radiotherapy or systemic treatments especially where benefits are marginal and alternative safe therapeutic options are available. Ongoing research is necessary to expand knowledge of the management of cancer in older adults. However, the pandemic presents a significant barrier and efforts should be made to ensure equitable access to clinical trials and prospective data collection to elucidate the outcomes of COVID-19 in this population.", "doi": "10.1016/j.jgo.2020.07.008", "pmid": "32709495", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1879-4068(20)30366-0"}, {"db": "pmc", "key": "PMC7365054"}], "notes": [], "created": "2020-11-30T08:44:15.803Z", "modified": "2020-11-30T08:44:15.827Z"}, {"entity": "publication", "iuid": "fc398b4a001242a99d74b29f8994cd26", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc398b4a001242a99d74b29f8994cd26.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc398b4a001242a99d74b29f8994cd26"}}, "title": "ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study.", "authors": [{"family": "Gill", "given": "Dipender", "initials": "D"}, {"family": "Arvanitis", "given": "Marios", "initials": "M"}, {"family": "Carter", "given": "Paul", "initials": "P"}, {"family": "Hern\u00e1ndez Cordero", "given": "Ana I", "initials": "AI"}, {"family": "Jo", "given": "Brian", "initials": "B"}, {"family": "Karhunen", "given": "Ville", "initials": "V"}, {"family": "Larsson", "given": "Susanna C", "initials": "SC"}, {"family": "Li", "given": "Xuan", "initials": "X"}, {"family": "Lockhart", "given": "Sam M", "initials": "SM"}, {"family": "Mason", "given": "Amy", "initials": "A"}, {"family": "Pashos", "given": "Evanthia", "initials": "E"}, {"family": "Saha", "given": "Ashis", "initials": "A"}, {"family": "Tan", "given": "Vanessa Y", "initials": "VY"}, {"family": "Zuber", "given": "Verena", "initials": "V"}, {"family": "Boss\u00e9", "given": "Yohan", "initials": "Y"}, {"family": "Fahle", "given": "Sarah", "initials": "S"}, {"family": "Hao", "given": "Ke", "initials": "K"}, {"family": "Jiang", "given": "Tao", "initials": "T"}, {"family": "Joubert", "given": "Philippe", "initials": "P"}, {"family": "Lunt", "given": "Alan C", "initials": "AC"}, {"family": "Ouwehand", "given": "Willem Hendrik", "initials": "WH"}, {"family": "Roberts", "given": "David J", "initials": "DJ"}, {"family": "Timens", "given": "Wim", "initials": "W"}, {"family": "van den Berge", "given": "Maarten", "initials": "M"}, {"family": "Watkins", "given": "Nicholas A", "initials": "NA"}, {"family": "Battle", "given": "Alexis", "initials": "A"}, {"family": "Butterworth", "given": "Adam S", "initials": "AS"}, {"family": "Danesh", "given": "John", "initials": "J"}, {"family": "Di Angelantonio", "given": "Emanuele", "initials": "E"}, {"family": "Engelhardt", "given": "Barbara E", "initials": "BE"}, {"family": "Peters", "given": "James E", "initials": "JE"}, {"family": "Sin", "given": "Don D", "initials": "DD"}, {"family": "Burgess", "given": "Stephen", "initials": "S"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "R Soc Open Sci", "issn": "2054-5703", "issn-l": null, "volume": "7", "issue": "11", "pages": "200958"}, "abstract": "Angiotensin-converting enzyme 2 (ACE2) and serine protease TMPRSS2 have been implicated in cell entry for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). The expression of ACE2 and TMPRSS2 in the lung epithelium might have implications for the risk of SARS-CoV-2 infection and severity of COVID-19. We use human genetic variants that proxy angiotensin-converting enzyme (ACE) inhibitor drug effects and cardiovascular risk factors to investigate whether these exposures affect lung ACE2 and TMPRSS2 gene expression and circulating ACE2 levels. We observed no consistent evidence of an association of genetically predicted serum ACE levels with any of our outcomes. There was weak evidence for an association of genetically predicted serum ACE levels with ACE2 gene expression in the Lung eQTL Consortium (p = 0.014), but this finding did not replicate. There was evidence of a positive association of genetic liability to type 2 diabetes mellitus with lung ACE2 gene expression in the Gene-Tissue Expression (GTEx) study (p = 4 \u00d7 10-4) and with circulating plasma ACE2 levels in the INTERVAL study (p = 0.03), but not with lung ACE2 expression in the Lung eQTL Consortium study (p = 0.68). There were no associations of genetically proxied liability to the other cardiometabolic traits with any outcome. This study does not provide consistent evidence to support an effect of serum ACE levels (as a proxy for ACE inhibitors) or cardiometabolic risk factors on lung ACE2 and TMPRSS2 expression or plasma ACE2 levels.", "doi": "10.1098/rsos.200958", "pmid": "33391794", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: H2020": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-07T11:18:38.095Z", "modified": "2021-02-26T08:45:48.911Z"}, {"entity": "publication", "iuid": "d1dfa2e8f18249f6a09ed3001da4e273", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1dfa2e8f18249f6a09ed3001da4e273.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1dfa2e8f18249f6a09ed3001da4e273"}}, "title": "A roadmap to the safe practice of forensic medicine in the COVID-19 pandemic.", "authors": [{"family": "Parekh", "given": "Utsav", "initials": "U"}, {"family": "Chariot", "given": "Patrick", "initials": "P"}, {"family": "Dang", "given": "Catherine", "initials": "C"}, {"family": "Stray-Pedersen", "given": "Arne", "initials": "A"}, {"family": "Druid", "given": "Henrik", "initials": "H"}, {"family": "Sajantila", "given": "Antti", "initials": "A"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "J Forensic Leg Med", "issn": "1878-7487", "volume": "76", "issue": null, "pages": "102036", "issn-l": "1752-928X"}, "abstract": "The COVID-19 pandemic has forced forensic practitioners to consider how we perform our normal duties, especially when those duties involve humans. The potential for contracting the virus from working in close contact with living sufferers is high, and we have yet to fully determine the risk of infection from the deceased. In an attempt to support the community, the Journal of Forensic & Legal Medicine has drawn together three articles which underline the importance of continued forensic medical practice during the pandemic and highlight some factors to consider in a Roadmap towards safe practice. Our Roadmap has intentionally taken an international perspective and supports other work we have published in the Journal on our collective response to the COVID-19 crisis.", "doi": "10.1016/j.jflm.2020.102036", "pmid": "33208233", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1752-928X(20)30143-8"}, {"db": "pmc", "key": "PMC7560269"}], "notes": [], "created": "2020-11-26T12:35:58.300Z", "modified": "2020-11-27T09:50:51.155Z"}, {"entity": "publication", "iuid": "6782ff1d9e184517b9530963a13c83ba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6782ff1d9e184517b9530963a13c83ba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6782ff1d9e184517b9530963a13c83ba"}}, "title": "H-WORK Project: Multilevel Interventions to Promote Mental Health in SMEs and Public Workplaces.", "authors": [{"family": "De Angelis", "given": "Marco", "initials": "M"}, {"family": "Giusino", "given": "Davide", "initials": "D"}, {"family": "Nielsen", "given": "Karina", "initials": "K"}, {"family": "Aboagye", "given": "Emmanuel", "initials": "E"}, {"family": "Christensen", "given": "Marit", "initials": "M"}, {"family": "Innstrand", "given": "Siw Tone", "initials": "ST"}, {"family": "Mazzetti", "given": "Greta", "initials": "G"}, {"family": "van den Heuvel", "given": "Machteld", "initials": "M"}, {"family": "Sijbom", "given": "Roy B L", "initials": "RBL"}, {"family": "Pelzer", "given": "Vince", "initials": "V"}, {"family": "Chiesa", "given": "Rita", "initials": "R"}, {"family": "Pietrantoni", "given": "Luca", "initials": "L"}], "type": "journal article", "published": "2020-10-31", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "21", "pages": null}, "abstract": "The paper describes the study design, research questions and methods of a large, international intervention project aimed at improving employee mental health and well-being in SMEs and public organisations. The study is innovative in multiple ways. First, it goes beyond the current debate on whether individual- or organisational-level interventions are most effective in improving employee health and well-being and tests the cumulative effects of multilevel interventions, that is, interventions addressing individual, group, leader and organisational levels. Second, it tailors its interventions to address the aftermaths of the Covid-19 pandemic and develop suitable multilevel interventions for dealing with new ways of working. Third, it uses realist evaluation to explore and identify the working ingredients of and the conditions required for each level of intervention, and their outcomes. Finally, an economic evaluation will assess both the cost-effectiveness analysis and the affordability of the interventions from the employer perspective. The study integrates the training transfer and the organisational process evaluation literature to develop toolkits helping end-users to promote mental health and well-being in the workplace.", "doi": "10.3390/ijerph17218035", "pmid": "33142745", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph17218035"}, {"db": "pmc", "key": "PMC7662282"}], "notes": [], "created": "2020-11-27T10:14:09.269Z", "modified": "2020-12-01T14:52:50.692Z"}, {"entity": "publication", "iuid": "545c2179da7042fdaa7d12bedd3fc5b8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/545c2179da7042fdaa7d12bedd3fc5b8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/545c2179da7042fdaa7d12bedd3fc5b8"}}, "title": "The COVID-19 pandemic as disjuncture: Lifelong learning in a context of fear.", "authors": [{"family": "Bjursell", "given": "Cecilia", "initials": "C"}], "type": "journal article", "published": "2020-10-30", "journal": {"title": "Int Rev Educ", "issn": "0020-8566", "volume": null, "issue": null, "pages": "1-17", "issn-l": null}, "abstract": "The COVID-19 pandemic has caused a number of fundamental changes in different societies, and can therefore be understood as creating \"disjuncture\" in our lives. Disjuncture is a concept proposed by adult educator Peter Jarvis to describe the phenomenon of what happens when an individual is confronted with an experience that conflicts with her/his previous understanding of the world. Faced with a situation that creates disjuncture, the person is compelled to find new knowledge and new ways of doing things; i.e., he/she must embark on a learning process. The recent introduction of social distancing as a measure aiming to reduce transmission of the COVID-19 virus has dramatically changed people's behaviour, but this measure does not only have preventive and desirable effects. There is an associated risk for increased isolation among the older generations of the population, as well as a change in intergenerational relationships. Although the current pandemic (as disjuncture) may potentially initiate major learning processes in the human collective, we should remember that disjuncture is often theorised within neutral, or even positive, contexts. In a context of fear, however, learning may result in a narrowing of mindsets and a rejection of collective efforts and solidarity between generations. In terms of the types of learning triggered by the current pandemic (as disjuncture), one problem is non-reflective learning, which primarily occurs on a behavioural level. We need to recognise this and engage in reflective learning if we are to make the choices that will lead to a society that is worth living in for all generations. Our goal must be to learn to be a person in a post-pandemic society.", "doi": "10.1007/s11159-020-09863-w", "pmid": "33144741", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "9863"}, {"db": "pmc", "key": "PMC7596631"}], "notes": [], "created": "2020-12-01T14:49:36.708Z", "modified": "2020-12-01T14:49:48.354Z"}, {"entity": "publication", "iuid": "3a127f769d8a486b86f9abc60a8625b6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a127f769d8a486b86f9abc60a8625b6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a127f769d8a486b86f9abc60a8625b6"}}, "title": "Pfam: The protein families database in 2021.", "authors": [{"family": "Mistry", "given": "Jaina", "initials": "J"}, {"family": "Chuguransky", "given": "Sara", "initials": "S"}, {"family": "Williams", "given": "Lowri", "initials": "L"}, {"family": "Qureshi", "given": "Matloob", "initials": "M"}, {"family": "Salazar", "given": "Gustavo A", "initials": "GA"}, {"family": "Sonnhammer", "given": "Erik L L", "initials": "ELL"}, {"family": "Tosatto", "given": "Silvio C E", "initials": "SCE"}, {"family": "Paladin", "given": "Lisanna", "initials": "L"}, {"family": "Raj", "given": "Shriya", "initials": "S"}, {"family": "Richardson", "given": "Lorna J", "initials": "LJ"}, {"family": "Finn", "given": "Robert D", "initials": "RD"}, {"family": "Bateman", "given": "Alex", "initials": "A"}], "type": "journal article", "published": "2020-10-30", "journal": {"title": "Nucleic Acids Res", "issn": "1362-4962", "volume": null, "issue": null, "issn-l": "0305-1048"}, "abstract": "The Pfam database is a widely used resource for classifying protein sequences into families and domains. Since Pfam was last described in this journal, over 350 new families have been added in Pfam 33.1 and numerous improvements have been made to existing entries. To facilitate research on COVID-19, we have revised the Pfam entries that cover the SARS-CoV-2 proteome, and built new entries for regions that were not covered by Pfam. We have reintroduced Pfam-B which provides an automatically generated supplement to Pfam and contains 136 730 novel clusters of sequences that are not yet matched by a Pfam family. The new Pfam-B is based on a clustering by the MMseqs2 software. We have compared all of the regions in the RepeatsDB to those in Pfam and have started to use the results to build and refine Pfam repeat families. Pfam is freely available for browsing and download at http://pfam.xfam.org/.", "doi": "10.1093/nar/gkaa913", "pmid": "33125078", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "5943818"}], "notes": [], "created": "2020-12-01T15:03:52.765Z", "modified": "2020-12-01T15:03:52.776Z"}, {"entity": "publication", "iuid": "1b4f51d5b73a4d18a3eb1a4c6b7afa37", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b4f51d5b73a4d18a3eb1a4c6b7afa37.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b4f51d5b73a4d18a3eb1a4c6b7afa37"}}, "title": "Multipel skleros och covid-19 \u2013 kunskapen \u00e4nnu begr\u00e4nsad", "authors": [{"family": "Iacobaeus", "given": "Ellen", "initials": "E"}, {"family": "Burman", "given": "Joachim", "initials": "J"}, {"family": "Landtblom", "given": "Anne-Marie", "initials": "A"}], "type": "journal article", "published": "2020-10-30", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": null, "doi": null, "pmid": "33150577", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "20129"}], "notes": [], "created": "2020-11-27T10:08:24.361Z", "modified": "2020-12-08T07:13:40.676Z"}, {"entity": "publication", "iuid": "65e7ee33ba5642e49ac02b48b23e635e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65e7ee33ba5642e49ac02b48b23e635e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65e7ee33ba5642e49ac02b48b23e635e"}}, "title": "Mathematical Models for COVID-19 Pandemic: A Comparative Analysis.", "authors": [{"family": "Adiga", "given": "Aniruddha", "initials": "A"}, {"family": "Dubhashi", "given": "Devdatt", "initials": "D"}, {"family": "Lewis", "given": "Bryan", "initials": "B"}, {"family": "Marathe", "given": "Madhav", "initials": "M"}, {"family": "Venkatramanan", "given": "Srinivasan", "initials": "S"}, {"family": "Vullikanti", "given": "Anil", "initials": "A"}], "type": "journal article", "published": "2020-10-30", "journal": {"title": "J Indian Inst Sci", "issn": "0970-4140", "volume": null, "issue": null, "pages": "1-15", "issn-l": "0970-4140"}, "abstract": "COVID-19 pandemic represents an unprecedented global health crisis in the last 100 years. Its economic, social and health impact continues to grow and is likely to end up as one of the worst global disasters since the 1918 pandemic and the World Wars. Mathematical models have played an important role in the ongoing crisis; they have been used to inform public policies and have been instrumental in many of the social distancing measures that were instituted worldwide. In this article, we review some of the important mathematical models used to support the ongoing planning and response efforts. These models differ in their use, their mathematical form and their scope.", "doi": "10.1007/s41745-020-00200-6", "pmid": "33144763", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "200"}, {"db": "pmc", "key": "PMC7596173"}], "notes": [], "created": "2020-11-27T11:01:16.970Z", "modified": "2020-12-01T14:48:54.078Z"}, {"entity": "publication", "iuid": "e096c3052ebf45a78d3bb90283e18088", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e096c3052ebf45a78d3bb90283e18088.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e096c3052ebf45a78d3bb90283e18088"}}, "title": "The complex distribution of SARS-CoV-2 in a population invalidates the use of the per capita rates of death and infection in international comparisons.", "authors": [{"family": "Silva", "given": "W T A F", "initials": "WTAF"}], "type": "letter", "published": "2020-10-29", "journal": {"title": "Public Health", "issn": "1476-5616", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.puhe.2020.10.019", "pmid": "33334594", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0033-3506(20)30461-3"}, {"db": "pmc", "key": "PMC7598416"}], "notes": [], "created": "2020-12-21T08:56:24.887Z", "modified": "2021-02-26T08:47:00.242Z"}, {"entity": "publication", "iuid": "55e43348983d455fad0063218a676042", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/55e43348983d455fad0063218a676042.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/55e43348983d455fad0063218a676042"}}, "title": "Risk factors for mortality in adult COVID-19 patients; frailty predicts fatal outcome in older patients.", "authors": [{"family": "Tehrani", "given": "Sara", "initials": "S"}, {"family": "Killander", "given": "Anna", "initials": "A"}, {"family": "\u00c5strand", "given": "Per", "initials": "P"}, {"family": "Jakobsson", "given": "Jan", "initials": "J"}, {"family": "Gille-Johnson", "given": "Patrik", "initials": "P"}], "type": "journal article", "published": "2020-10-29", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": null, "issue": null, "pages": null}, "abstract": "This study investigated demographics, co-morbidities and death rate in hospitalized patients with confirmed COVID-19. In addition, we hypothesized that functional status, according to Clinical Frailty Scale (CFS), in patients aged 65 years and older is a better predictor of poor outcome than age and co-morbidities.\r\n\r\nA total of 255 randomly selected COVID-19 patients admitted at a university hospital were included and followed for 60 days. Patient data was extracted manually from the electronic health records using a standardized protocol.\r\n\r\nThe age of the study population ranged between 20 and 103 years, (mean age was 66\u00b117 years). Hypertension, diabetes mellitus and obesity were the three most prevalent co-morbidities. At the 60-day follow-up, 70 patients (27%) had died. In multivariate analyses, age, chronic kidney disease and previous stroke were associated with death. Most fatal cases (90%) occurred in older patients. Among the older patients, CFS was the only predictor of death in multivariate analyses.\r\n\r\nThis study shows that higher age, chronic kidney disease and previous stroke significantly contribute to a fatal outcome in hospitalized patients with COVID-19. In patients aged 65 years and older, CFS was the strongest prognostic factor for mortality.", "doi": "10.1016/j.ijid.2020.10.071", "pmid": "33130213", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(20)32276-1"}], "notes": [], "created": "2020-11-27T10:18:27.233Z", "modified": "2022-11-09T08:41:21.795Z"}, {"entity": "publication", "iuid": "7d0b505b0cde44238632734beb405eaa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d0b505b0cde44238632734beb405eaa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d0b505b0cde44238632734beb405eaa"}}, "title": "Emergency Healthcare Providers' Perceptions of Preparedness and Willingness to Work during Disasters and Public Health Emergencies.", "authors": [{"family": "Sultan", "given": "Mohammed Ali Salem", "initials": "MAS"}, {"family": "L\u00f8we S\u00f8rensen", "given": "Jarle", "initials": "J"}, {"family": "Carlstr\u00f6m", "given": "Eric", "initials": "E"}, {"family": "Mortelmans", "given": "Luc", "initials": "L"}, {"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}], "type": "journal article", "published": "2020-10-29", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "volume": "8", "issue": "4", "issn-l": null}, "abstract": "This study evaluates the perceptions of preparedness and willingness to work during disasters and public health emergencies among 213 healthcare workers at hospitals in the southern region of Saudi Arabia by using a quantitative survey (Fight or Flight). The results showed that participants' willingness to work unconditionally during disasters and emergencies varied based on the type of condition: natural disasters (61.97%), seasonal influenza pandemic (52.58%), smallpox pandemic (47.89%), SARS/COVID-19 pandemic (43.56%), special flu pandemic (36.15%), mass shooting (37.56%), chemical incident and bombing threats (31.92%), biological events (28.17%), Ebola outbreaks (27.7%), and nuclear incident (24.88%). A lack of confidence and the absence of safety assurance for healthcare workers and their family members were the most important reasons cited. The co-variation between age and education versus risk and danger by Spearman's rho confirmed a small negative correlation between education and danger at a 95% level of significance, meaning that educated healthcare workers have less fear to work under dangerous events. Although the causes of unsuccessful management of disasters and emergencies may vary, individuals' characteristics, such as lack of confidence and emotional distractions because of uncertainty about the safety issues, may also play a significant role. Besides educational initiatives, other measures, which guarantee the safety of healthcare providers and their family members, should be established and implemented.", "doi": "10.3390/healthcare8040442", "pmid": "33138164", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "healthcare8040442"}], "notes": [], "created": "2020-12-01T14:59:58.421Z", "modified": "2021-02-26T08:45:48.385Z"}, {"entity": "publication", "iuid": "8dad937a4d5c4d60a37ee7eb0be35ca4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8dad937a4d5c4d60a37ee7eb0be35ca4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8dad937a4d5c4d60a37ee7eb0be35ca4"}}, "title": "The digital immunization system of the future: imagining a patient-centric, interoperable immunization information system.", "authors": [{"family": "Atkinson", "given": "Katherine M", "initials": "KM"}, {"family": "Mithani", "given": "Salima Saleem", "initials": "SS"}, {"family": "Bell", "given": "Cameron", "initials": "C"}, {"family": "Rubens-Augustson", "given": "Taylor", "initials": "T"}, {"family": "Wilson", "given": "Kumanan", "initials": "K"}], "type": "journal article", "published": "2020-10-28", "journal": {"title": "Ther Adv Vaccines Immunother", "issn": "2515-1355", "volume": "8", "issue": null, "pages": "2515135520967203", "issn-l": null}, "abstract": "To ensure the effectiveness of increasingly complex immunization programs in upper-middle and high-income settings, comprehensive information systems are needed to track immunization uptake at individual and population levels. The maturity of cloud systems and mobile technologies has created new possibilities for immunization information systems. In this paper, we describe a vision for the next generation of digital immunization information systems for upper-middle and high-income settings based on our experience in Canada. These systems center on the premise that the public is engaged and informed about the immunization process beyond their interaction with primary care, and that they will be a contributor and auditor of immunization data. The digital immunization system of the future will facilitate reporting of adverse events following immunization, issue digital immunization receipts, permit identification of areas of need and allow for delivery of interventions targeting these areas. Through features like immunization reminders and targeted immunization promotion campaigns, the system will reduce many of the known barriers that influence immunization rates. In light of the global COVID-19 pandemic, adaptive digital public health information systems will be required to guide the rollout and post-market surveillance of the SARS-CoV-2 vaccine.", "doi": "10.1177/2515135520967203", "pmid": "33681700", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1177_2515135520967203"}, {"db": "pmc", "key": "PMC7900792"}], "notes": [], "created": "2021-03-09T15:36:05.453Z", "modified": "2021-03-09T15:36:05.475Z"}, {"entity": "publication", "iuid": "b15ab0bc7c204f5eb3258fdd9c3b38e3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b15ab0bc7c204f5eb3258fdd9c3b38e3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b15ab0bc7c204f5eb3258fdd9c3b38e3"}}, "title": "Similar Clinical Course and Significance of Circulating Innate and Adaptive Immune Cell Counts in STEMI and COVID-19.", "authors": [{"family": "de Dios", "given": "Elena", "initials": "E"}, {"family": "Rios-Navarro", "given": "Cesar", "initials": "C"}, {"family": "Perez-Sole", "given": "Nerea", "initials": "N"}, {"family": "Gavara", "given": "Jose", "initials": "J"}, {"family": "Marcos-Garces", "given": "Victor", "initials": "V"}, {"family": "Rodr\u00edguez", "given": "Enrique", "initials": "E"}, {"family": "Carratal\u00e1", "given": "Arturo", "initials": "A"}, {"family": "Forner", "given": "Maria J", "initials": "MJ"}, {"family": "Navarro", "given": "Jorge", "initials": "J"}, {"family": "Blasco", "given": "Maria L", "initials": "ML"}, {"family": "Bondia", "given": "Elvira", "initials": "E"}, {"family": "Signes-Costa", "given": "Jaime", "initials": "J"}, {"family": "Vila", "given": "Jose M", "initials": "JM"}, {"family": "Forteza", "given": "Maria J", "initials": "MJ"}, {"family": "Chorro", "given": "Francisco J", "initials": "FJ"}, {"family": "Bodi", "given": "Vicente", "initials": "V"}], "type": "journal article", "published": "2020-10-28", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "9", "issue": "11", "issn-l": "2077-0383"}, "abstract": "This study aimed to assess the time course of circulating neutrophil and lymphocyte counts and their ratio (NLR) in ST-segment elevation myocardial infarction (STEMI) and coronavirus disease (COVID)-19 and explore their associations with clinical events and structural damage. Circulating neutrophil, lymphocyte and NLR were sequentially measured in 659 patients admitted for STEMI and in 103 COVID-19 patients. The dynamics detected in STEMI (within a few hours) were replicated in COVID-19 (within a few days). In both entities patients with events and with severe structural damage displayed higher neutrophil and lower lymphocyte counts. In both scenarios, higher maximum neutrophil and lower minimum lymphocyte counts were associated with more events and more severe organ damage. NLR was higher in STEMI and COVID-19 patients with the worst clinical and structural outcomes. A canonical deregulation of the immune response occurs in STEMI and COVID-19 patients. Boosted circulating innate (neutrophilia) and depressed circulating adaptive immunity (lymphopenia) is associated with more events and severe organ damage. A greater understanding of these critical illnesses is pivotal to explore novel alternative therapies.", "doi": "10.3390/jcm9113484", "pmid": "33126723", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "jcm9113484"}], "notes": [], "created": "2020-11-27T10:19:02.909Z", "modified": "2021-02-26T08:45:03.195Z"}, {"entity": "publication", "iuid": "95d2453a375346cab92217de9d6b6367", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95d2453a375346cab92217de9d6b6367.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95d2453a375346cab92217de9d6b6367"}}, "title": "Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19?", "authors": [{"family": "Palit", "given": "Partha", "initials": "P"}, {"family": "Chattopadhyay", "given": "Debprasad", "initials": "D"}, {"family": "Thomas", "given": "Sabu", "initials": "S"}, {"family": "Kundu", "given": "Amit", "initials": "A"}, {"family": "Kim", "given": "Hyung Sik", "initials": "HS"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}], "type": "journal article", "published": "2020-10-28", "journal": {"title": "Phytomedicine", "issn": "1618-095X", "volume": null, "issue": null, "pages": "153396", "issn-l": "0944-7113"}, "abstract": "Currently, novel coronavirus disease (Covid-19) outbreak creates global panic across the continents, as people from almost all countries and territories have been affected by this highly contagious viral disease. The scenario is deteriorating due to lack of proper & specific target-oriented pharmacologically safe prophylactic agents or drugs, and or any effective vaccine. drug development is urgently required to back in the normalcy in the community and to combat this pandemic.\n\nThus, we have proposed two novel drug targets, Furin and TMPRSS2, as Covid-19 treatment strategy. We have highlighted this target-oriented novel drug delivery strategy, based on their pathophysiological implication on SARS-CoV-2 infection, as evident from earlier SARS-CoV-1, MERS, and influenza virus infection via host cell entry, priming, fusion, and endocytosis. STUDY DESIGN & METHODS: An earlier study suggested that Furin and TMPRSS2 knockout mice had reduced level of viral load and a lower degree of organ damage such as the lung. The present study thus highlights the promise of some selected novel and potential anti-viral Phytopharmaceutical that bind to Furin and TMPRSS2 as target.\n\nFew of them had shown promising anti-viral response in both preclinical and clinical study with acceptable therapeutic safety-index.\n\nHence, this strategy may limit life-threatening Covid-19 infection and its mortality rate through nano-suspension based intra-nasal or oral nebulizer spray, to treat mild to moderate SARS-COV-2 infection when Furin and TMPRSS2 receptor may initiate to express and activate for processing the virus to cause cellular infection by replication within the host cell and blocking of host-viral interaction.", "doi": "10.1016/j.phymed.2020.153396", "pmid": "33380375", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0944-7113(20)30227-0"}, {"db": "pmc", "key": "PMC7591300"}], "notes": [], "created": "2021-01-07T12:09:39.696Z", "modified": "2021-01-07T12:09:39.707Z"}, {"entity": "publication", "iuid": "101defb34cf1411892223412d5e22d70", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/101defb34cf1411892223412d5e22d70.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/101defb34cf1411892223412d5e22d70"}}, "title": "Impact of COVID-19-Related Lockdown on Psychosocial, Cognitive, and Functional Well-Being in Adults With Down Syndrome.", "authors": [{"family": "Villani", "given": "Emanuele Rocco", "initials": "ER"}, {"family": "Vetrano", "given": "Davide Liborio", "initials": "DL"}, {"family": "Damiano", "given": "Cecilia", "initials": "C"}, {"family": "Paola", "given": "Antonella Di", "initials": "AD"}, {"family": "Ulgiati", "given": "Aurora Maria", "initials": "AM"}, {"family": "Martin", "given": "Lynn", "initials": "L"}, {"family": "Hirdes", "given": "John P", "initials": "JP"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Bernabei", "given": "Roberto", "initials": "R"}, {"family": "Onder", "given": "Graziano", "initials": "G"}, {"family": "Carf\u00ec", "given": "Angelo", "initials": "A"}], "type": "journal article", "published": "2020-10-28", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "issn-l": "1664-0640", "volume": "11", "issue": null, "pages": "578686"}, "abstract": "People with Down Syndrome (DS) have a high prevalence of physical and psychiatric comorbidities and experience early-onset dementia. With the outbreak of CoVID-19 pandemic, strict social isolation measures have been necessary to prevent the spreading of the disease. Effects of this lockdown period on behavior, mood and cognition in people with DS have not been assessed so far. In the present clinical study, we investigated the impact of CoVID-19-related lockdown on psychosocial, cognitive and functional well-being in a sample population of 46 adults with DS. The interRAI Intellectual Disability standardized assessment instrument, which includes measures of social withdrawal, functional impairment, aggressive behavior and depressive symptoms, was used to perform a three time-point evaluation (two pre-lockdown and one post-lockdown) in 37 subjects of the study sample, and a two time point evaluation (one pre- and one post-lockdown) in 9 subjects. Two mixed linear regression models - one before and one after the lockdown - have been fitted for each scale in order to investigate the change in the time-dependent variation of the scores. In the pre-lockdown period, significant worsening over time (i.e., per year) was found for the Depression Rating Scale score (\u03b2 = 0.55; 95% CI 0.34; 0.76). In the post-lockdown period, a significant worsening in social withdrawal (\u03b2 = 3.05, 95% CI 0.39; 5.70), instrumental activities of daily living (\u03b2 = 1.13, 95% CI 0.08; 2.18) and depression rating (\u03b2 = 1.65, 95% CI 0.33; 2.97) scales scores was observed, as was a significant improvement in aggressive behavior (\u03b2 = -1.40, 95% CI -2.69; -0.10). Despite the undoubtful importance of the lockdown in order to reduce the spreading of the CoVID-19 pandemic, the related social isolation measures suggest an exacerbation of depressive symptoms and a worsening in functional status in a sample of adults with DS. At the opposite, aggressive behavior was reduced after the lockdown period. This finding could be related to the increase of negative and depressive symptoms in the study population. Studies with longer follow-up period are needed to assess persistence of these effects.", "doi": "10.3389/fpsyt.2020.578686", "pmid": "33192717", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7655916"}], "notes": [], "created": "2020-11-27T09:55:50.227Z", "modified": "2023-06-19T15:28:57.715Z"}, {"entity": "publication", "iuid": "d019e593ded147cd8a6fa483b8202a56", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d019e593ded147cd8a6fa483b8202a56.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d019e593ded147cd8a6fa483b8202a56"}}, "title": "Emergency department crowding and hospital transformation during COVID-19, a retrospective, descriptive study of a university hospital in Stockholm, Sweden.", "authors": [{"family": "Af Ugglas", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Skyttberg", "given": "Niclas", "initials": "N"}, {"family": "Wladis", "given": "Andreas", "initials": "A"}, {"family": "Dj\u00e4rv", "given": "Therese", "initials": "T"}, {"family": "Holzmann", "given": "Martin J", "initials": "MJ"}], "type": "journal article", "published": "2020-10-28", "journal": {"title": "Scand J Trauma Resusc Emerg Med", "issn": "1757-7241", "volume": "28", "issue": "1", "pages": "107", "issn-l": "1757-7241"}, "abstract": "COVID-19 presents challenges to the emergency care system that could lead to emergency department (ED) crowding. The Huddinge site at the Karolinska university hospital (KH) responded through a rapid transformation of inpatient care capacity together with changing working methods in the ED. The aim is to describe the KH response to the COVID-19 crisis, and how ED crowding, and important input, throughput and output factors for ED crowding developed at KH during a 30-day baseline period followed by the first 60 days of the COVID-19 outbreak in Stockholm Region.\n\nDifferent phases in the development of the crisis were described and identified retrospectively based on major events that changed the conditions for the ED. Results were presented for each phase separately. The outcome ED length of stay (ED LOS) was calculated with mean and 95% confidence intervals. Input, throughput, output and demographic factors were described using distributions, proportions and means. Pearson correlation between ED LOS and emergency ward occupancy by phase was estimated with 95% confidence interval.\n\nAs new working methods were introduced between phase 2 and 3, ED LOS declined from mean (95% CI) 386 (373-399) minutes to 307 (297-317). Imaging proportion was reduced from 29 to 18% and admission rate increased from 34 to 43%. Correlation (95% CI) between emergency ward occupancy and ED LOS by phase was 0.94 (0.55-0.99).\n\nIt is possible to avoid ED crowding, even during extreme and quickly changing conditions by leveraging previously known input, throughput and output factors. One key factor was the change in working methods in the ED with higher competence, less diagnostics and increased focus on rapid clinical admission decisions. Another important factor was the reduction in bed occupancy in emergency wards that enabled a timely admission to inpatient care. A key limitation was the retrospective study design.", "doi": "10.1186/s13049-020-00799-6", "pmid": "33115521", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13049-020-00799-6"}, {"db": "pmc", "key": "PMC7592192"}], "notes": [], "created": "2020-11-27T10:22:02.875Z", "modified": "2021-02-26T08:45:48.728Z"}, {"entity": "publication", "iuid": "cbf9d53589f342709917243e17cdc214", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cbf9d53589f342709917243e17cdc214.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cbf9d53589f342709917243e17cdc214"}}, "title": "Covid-19: risks to healthcare workers and their families.", "authors": [{"family": "Karlsson", "given": "Ulf", "initials": "U"}, {"family": "Fraenkel", "given": "Carl-Johan", "initials": "C"}], "type": "editorial", "published": "2020-10-28", "journal": {"title": "BMJ", "issn": "1756-1833", "issn-l": null, "volume": "371", "issue": null, "pages": "m3944"}, "abstract": "Editorial", "doi": "10.1136/bmj.m3944", "pmid": "33115772", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-01T15:11:01.785Z", "modified": "2020-12-01T15:11:37.521Z"}, {"entity": "publication", "iuid": "12fc3149e6b4409e9a1f725ef4387c4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/12fc3149e6b4409e9a1f725ef4387c4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/12fc3149e6b4409e9a1f725ef4387c4d"}}, "title": "The Impact of the COVID-19 Pandemic and Emergency Distance Teaching on the Psychological Status of University Teachers: A Cross-Sectional Study in Jordan.", "authors": [{"family": "Akour", "given": "Amal", "initials": "A"}, {"family": "Al-Tammemi", "given": "Ala'a B", "initials": "AB"}, {"family": "Barakat", "given": "Muna", "initials": "M"}, {"family": "Kanj", "given": "Rama", "initials": "R"}, {"family": "Fakhouri", "given": "Hussam N", "initials": "HN"}, {"family": "Malkawi", "given": "Ahmad", "initials": "A"}, {"family": "Musleh", "given": "Ghadeer", "initials": "G"}], "type": "journal article", "published": "2020-10-27", "journal": {"title": "Am J Trop Med Hyg", "issn": "1476-1645", "volume": null, "issue": null, "issn-l": "0002-9637"}, "abstract": "The COVID-19 pandemic has struck many countries globally. Jordan has implemented strict nationwide control measures to halt the viral spread, one of which was the closure of universities and shifting to remote teaching. The impact of this pandemic could extend beyond the risk of physical harm to substantial psychological consequences. Our study aimed at assessing 1) psychological status, 2) challenges of distance teaching, and 3) coping activities and pandemic-related concerns among university teachers in Jordan in the midst of COVID-19-related quarantine and control measures. We conducted a cross-sectional study using an anonymous online survey. The measure of psychological distress was obtained using a validated Arabic version of the Kessler Distress Scale (K10). Other information collected included sociodemographic profile, methods used to handle distress, motivation to participate in distance teaching, and challenges of distance teaching as well as the most worrisome issues during this pandemic. Three hundred eighty-two university teachers returned completed surveys. Results of K10 showed that 31.4% of respondents had severe distress and 38.2% had mild to moderate distress. Whereas gender was not associated with distress severity, age had a weak negative correlation (Rho = -0.19, P < 0.0001). Interestingly, most teachers had moderate to high motivation for distance teaching. Engagement with family was the most reported self-coping activity. More than half of the participants were most concerned and fearful about SARS-CoV-2 infection. In conclusion, university teachers have shown to exhibit various levels of psychological distress and challenges during the implementation of precautionary national measures in the battle against COVID-19 in Jordan.", "doi": "10.4269/ajtmh.20-0877", "pmid": "33124547", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-01T15:07:37.597Z", "modified": "2020-12-01T15:07:37.607Z"}, {"entity": "publication", "iuid": "83fad77501a1445eb5aea9d17c557e17", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/83fad77501a1445eb5aea9d17c557e17.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/83fad77501a1445eb5aea9d17c557e17"}}, "title": "On the relationship between BCG coverage and national Covid-19 outcome: could \"heterologous\" herd immunity explain why some countries are better off?", "authors": [{"family": "Lerm", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2020-10-27", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": "288", "issue": "6", "pages": "682-688", "issn-l": null}, "abstract": "The Covid-19 pandemic has affected most parts of the global society since its emergence and the scientific community has been challenged with challenging questions urgently demanding answers. One of the early hypotheses on Covid-19 outcome was that some protection could be offered by the tuberculosis vaccine (BCG) and several clinical studies were initiated along with the emergence of numerous observational studies on the relationship between BCG and Covid-19 severity. In the present work, I demonstrate a strong correlation between the number of years that countries implemented BCG vaccination plans and age-standardised mortality rates during the first months of the pandemic in Europe. Further analyses of age groups in two European countries with comparably few confounding factors and easily identifiable groups of BCG-vaccinated and non-vaccinated subgroups suggest a population-level effect of BCG on national outcomes of Covid-19. This phenomenon of \"heterologous herd immunity\" deserves further investigation, both in epidemiological and experimental studies.", "doi": "10.1111/joim.13198", "pmid": "33107999", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-01T15:17:52.407Z", "modified": "2021-04-28T15:30:30.449Z"}, {"entity": "publication", "iuid": "363ed9df30a74eca934bca383d9cf3b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/363ed9df30a74eca934bca383d9cf3b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/363ed9df30a74eca934bca383d9cf3b4"}}, "title": "Global impact of the COVID-19 pandemic on cytopathology practice: Results from an international survey of laboratories in 23 countries.", "authors": [{"family": "Vigliar", "given": "Elena", "initials": "E"}, {"family": "Cepurnaite", "given": "Rima", "initials": "R"}, {"family": "Alcaraz-Mateos", "given": "Eduardo", "initials": "E"}, {"family": "Ali", "given": "Syed Z", "initials": "SZ"}, {"family": "Baloch", "given": "Zubair W", "initials": "ZW"}, {"family": "Bellevicine", "given": "Claudio", "initials": "C"}, {"family": "Bongiovanni", "given": "Massimo", "initials": "M"}, {"family": "Botsun", "given": "Pavlina", "initials": "P"}, {"family": "Bruzzese", "given": "Dario", "initials": "D"}, {"family": "Bubendorf", "given": "Lukas", "initials": "L"}, {"family": "B\u00fcttner", "given": "Reinhard", "initials": "R"}, {"family": "Canberk", "given": "Sule", "initials": "S"}, {"family": "Capitanio", "given": "Arrigo", "initials": "A"}, {"family": "Casadio", "given": "Chiara", "initials": "C"}, {"family": "Cazacu", "given": "Eugeniu", "initials": "E"}, {"family": "Cochand-Priollet", "given": "Beatrix", "initials": "B"}, {"family": "D'Amuri", "given": "Alessandro", "initials": "A"}, {"family": "Eloy", "given": "Catarina", "initials": "C"}, {"family": "Engels", "given": "Marianne", "initials": "M"}, {"family": "Fadda", "given": "Guido", "initials": "G"}, {"family": "Fontanini", "given": "Gabriella", "initials": "G"}, {"family": "Fulciniti", "given": "Franco", "initials": "F"}, {"family": "Hofman", "given": "Paul", "initials": "P"}, {"family": "Iaccarino", "given": "Antonino", "initials": "A"}, {"family": "Ieni", "given": "Antonio", "initials": "A"}, {"family": "Jiang", "given": "Xiaoyin Sara", "initials": "XS"}, {"family": "Kakudo", "given": "Kennichi", "initials": "K"}, {"family": "Kern", "given": "Izidor", "initials": "I"}, {"family": "Kholova", "given": "Ivana", "initials": "I"}, {"family": "Liu", "given": "Chinhua", "initials": "C"}, {"family": "Lobo", "given": "Anandi", "initials": "A"}, {"family": "Lozano", "given": "Maria D", "initials": "MD"}, {"family": "Malapelle", "given": "Umberto", "initials": "U"}, {"family": "Maleki", "given": "Zahra", "initials": "Z"}, {"family": "Michelow", "given": "Pamela", "initials": "P"}, {"family": "Musayev", "given": "Jamal", "initials": "J"}, {"family": "\u00d6zg\u00fcn", "given": "Gonca", "initials": "G"}, {"family": "Oznur", "given": "Meltem", "initials": "M"}, {"family": "Peir\u00f3 Marqu\u00e9s", "given": "Francisca Maria", "initials": "FM"}, {"family": "Pisapia", "given": "Pasquale", "initials": "P"}, {"family": "Poller", "given": "David", "initials": "D"}, {"family": "Pyzlak", "given": "Michal", "initials": "M"}, {"family": "Robinson", "given": "Betsy", "initials": "B"}, {"family": "Rossi", "given": "Esther Diana", "initials": "ED"}, {"family": "Roy-Chowdhuri", "given": "Sinchita", "initials": "S"}, {"family": "Saieg", "given": "Mauro", "initials": "M"}, {"family": "Savic Prince", "given": "Spasenija", "initials": "S"}, {"family": "Schmitt", "given": "Fernando C", "initials": "FC"}, {"family": "Javier Segu\u00ed Iv\u00e1\u00f1ez", "given": "Francisco", "initials": "F"}, {"family": "\u0160toos-Vei\u0107", "given": "Tajana", "initials": "T"}, {"family": "Sulaieva", "given": "Oksana", "initials": "O"}, {"family": "Sweeney", "given": "Brenda J", "initials": "BJ"}, {"family": "Tuccari", "given": "Giovanni", "initials": "G"}, {"family": "van Velthuysen", "given": "Marie-Louise", "initials": "ML"}, {"family": "VanderLaan", "given": "Paul A", "initials": "PA"}, {"family": "Vielh", "given": "Philippe", "initials": "P"}, {"family": "Viola", "given": "Patrizia", "initials": "P"}, {"family": "Voorham", "given": "Rinus", "initials": "R"}, {"family": "Weynand", "given": "Birgit", "initials": "B"}, {"family": "Zeppa", "given": "Pio", "initials": "P"}, {"family": "Faquin", "given": "William C", "initials": "WC"}, {"family": "Pitman", "given": "Martha Bishop", "initials": "MB"}, {"family": "Troncone", "given": "Giancarlo", "initials": "G"}], "type": "journal article", "published": "2020-10-27", "journal": {"title": "Cancer Cytopathol", "issn": "1934-6638", "volume": null, "issue": null, "issn-l": null}, "abstract": "To the authors' knowledge, the impact of the coronavirus disease 2019 (COVID-19) pandemic on cytopathology practices worldwide has not been investigated formally. In the current study, data from 41 respondents from 23 countries were reported.\n\nData regarding the activity of each cytopathology laboratory during 4 weeks of COVID-19 lockdown were collected and compared with those obtained during the corresponding period in 2019. The overall number and percentage of exfoliative and fine-needle aspiration cytology samples from each anatomic site were recorded. Differences in the malignancy and suspicious rates between the 2 periods were analyzed using a meta-analytical approach.\n\nOverall, the sample volume was lower compared with 2019 (104,319 samples vs 190,225 samples), with an average volume reduction of 45.3% (range, 0.1%-98.0%). The percentage of samples from the cervicovaginal tract, thyroid, and anorectal region was significantly reduced (P < .05). Conversely, the percentage of samples from the urinary tract, serous cavities, breast, lymph nodes, respiratory tract, salivary glands, central nervous system, gastrointestinal tract, pancreas, liver, and biliary tract increased (P < .05). An overall increase of 5.56% (95% CI, 3.77%-7.35%) in the malignancy rate in nongynecological samples during the COVID-19 pandemic was observed. When the suspicious category was included, the overall increase was 6.95% (95% CI, 4.63%-9.27%).\n\nThe COVID-19 pandemic resulted in a drastic reduction in the total number of cytology specimens regardless of anatomic site or specimen type. The rate of malignancy increased, reflecting the prioritization of patients with cancer who were considered to be at high risk. Prospective monitoring of the effect of delays in access to health services during the lockdown period is warranted.", "doi": "10.1002/cncy.22373", "pmid": "33108683", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-01T15:16:41.610Z", "modified": "2020-12-01T15:16:41.634Z"}, {"entity": "publication", "iuid": "0a1734ad80324354b397d4c7f8f4ca2f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a1734ad80324354b397d4c7f8f4ca2f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a1734ad80324354b397d4c7f8f4ca2f"}}, "title": "Frailty and comorbidity in predicting community COVID-19 mortality in the UK Biobank: the effect of sampling", "authors": [{"family": "Mak", "given": "Jonathan K L", "initials": "JKL"}, {"family": "Kuja-Halkola", "given": "Ralf", "initials": "R"}, {"family": "Wang", "given": "Yunzhang", "initials": "Y"}, {"family": "H\u00e4gg", "given": "Sara", "initials": "S"}, {"family": "Jylh\u00e4v\u00e4", "given": "Juulia", "initials": "J"}], "type": "posted-content", "published": "2020-10-27", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.10.22.20217489", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-09T19:30:28.062Z", "modified": "2021-06-09T19:30:46.038Z"}, {"entity": "publication", "iuid": "d780ed20b16b4f81a2bc925a264c0ab8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d780ed20b16b4f81a2bc925a264c0ab8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d780ed20b16b4f81a2bc925a264c0ab8"}}, "title": "Dashboard of Sentiment in Austrian Social Media During COVID-19.", "authors": [{"family": "Pellert", "given": "Max", "initials": "M"}, {"family": "Lasser", "given": "Jana", "initials": "J"}, {"family": "Metzler", "given": "Hannah", "initials": "H"}, {"family": "Garcia", "given": "David", "initials": "D"}], "type": "journal article", "published": "2020-10-26", "journal": {"title": "Front Big Data", "issn": "2624-909X", "volume": "3", "issue": null, "pages": "32", "issn-l": null}, "abstract": "To track online emotional expressions on social media platforms close to real-time during the COVID-19 pandemic, we built a self-updating monitor of emotion dynamics using digital traces from three different data sources in Austria. This allows decision makers and the interested public to assess dynamics of sentiment online during the pandemic. We used web scraping and API access to retrieve data from the news platform derstandard.at, Twitter, and a chat platform for students. We documented the technical details of our workflow to provide materials for other researchers interested in building a similar tool for different contexts. Automated text analysis allowed us to highlight changes of language use during COVID-19 in comparison to a neutral baseline. We used special word clouds to visualize that overall difference. Longitudinally, our time series showed spikes in anxiety that can be linked to several events and media reporting. Additionally, we found a marked decrease in anger. The changes lasted for remarkably long periods of time (up to 12 weeks). We have also discussed these and more patterns and connect them to the emergence of collective emotions. The interactive dashboard showcasing our data is available online at http://www.mpellert.at/covid19_monitor_austria/. Our work is part of a web archive of resources on COVID-19 collected by the Austrian National Library.", "doi": "10.3389/fdata.2020.00032", "pmid": "33693405", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7931924"}, {"db": "URL", "key": "http://www.mpellert.at/covid19_monitor_austria/.", "description": "http://www.mpellert.at/covid19_monitor_austria/."}], "notes": [], "created": "2021-03-12T06:36:40.432Z", "modified": "2021-03-12T06:37:17.326Z"}, {"entity": "publication", "iuid": "7098ed40379b4bd092504e310993f52d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7098ed40379b4bd092504e310993f52d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7098ed40379b4bd092504e310993f52d"}}, "title": "Therapist-Supported Online Interventions for Children and Young People With Tic Disorders: Lessons Learned From a Randomized Controlled Trial and Considerations for Future Practice.", "authors": [{"family": "Chamberlain", "given": "Liam R", "initials": "LR"}, {"family": "Hall", "given": "Charlotte L", "initials": "CL"}, {"family": "Andr\u00e9n", "given": "Per", "initials": "P"}, {"family": "Davies", "given": "E Bethan", "initials": "EB"}, {"family": "Kilgariff", "given": "Joseph", "initials": "J"}, {"family": "Kouzoupi", "given": "Natalia", "initials": "N"}, {"family": "Murphy", "given": "Tara", "initials": "T"}, {"family": "Hollis", "given": "Chris", "initials": "C"}], "type": "journal article", "published": "2020-10-23", "journal": {"title": "JMIR Ment Health", "issn": "2368-7959", "issn-l": null, "volume": "7", "issue": "10", "pages": "e19600"}, "abstract": "In recent years, research into internet-based cognitive behavioral therapy (iCBT) has suggested that therapist-guided digital interventions have greater engagement, adherence, and effectiveness than self-directed digital therapies. While research has focused on the effectiveness of, and adherence to, these interventions, less attention has been paid to their implementation in practice and what aspects of the therapist role support success. An understanding of the key factors related to the therapist role and intervention delivery is required if these iCBTs are to be applied in routine clinical care and outcomes optimized. In light of the coronavirus disease 2019 (COVID-19) pandemic, there is greater emphasis on allowing patients access to remote therapies. We report the experiences and reflections of 4 therapists and their 2 supervisors in delivering an online, therapist-supported intervention in a randomized controlled trial for children and young people with tic disorders (the Online Remote Behavioural Intervention for Tics [ORBIT] trial). Themes discussed include the importance of training, supervision, creating support documents/manuals, and record keeping. Alongside this are communication strategies used by therapists to encourage patient adherence and treatment effectiveness. These include rapport building, treatment personalization, and suggestions for overcoming non-engagement. These reflections offer important considerations for the delivery of iCBTs as well as implications associated with the implementation of these interventions in existing services and future research studies. We share thoughts on where iCBTs may sit in a stepped care model, how services may deal with comorbid conditions, and the potential role of iCBTs in collecting clinical data.", "doi": "10.2196/19600", "pmid": "33095180", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "v7i10e19600"}, {"db": "pmc", "key": "PMC7647804"}], "notes": [], "created": "2020-12-01T15:35:12.013Z", "modified": "2022-11-09T08:42:39.936Z"}, {"entity": "publication", "iuid": "937cc4cd55c042fcb79e0924979ed1e9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/937cc4cd55c042fcb79e0924979ed1e9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/937cc4cd55c042fcb79e0924979ed1e9"}}, "title": "The impact of delirium on outcomes for older adults hospitalised with COVID-19.", "authors": [{"family": "Marengoni", "given": "Alessandra", "initials": "A"}, {"family": "Zucchelli", "given": "Alberto", "initials": "A"}, {"family": "Grande", "given": "Giulia", "initials": "G"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Rizzuto", "given": "Debora", "initials": "D"}], "type": "journal article", "published": "2020-10-23", "journal": {"title": "Age Ageing", "issn": "1468-2834", "volume": "49", "issue": "6", "pages": "923-926", "issn-l": null}, "abstract": "Delirium is a frequent condition in hospitalized older patients and it usually has a negative prognostic value. A direct effect of SARS-COV-2 on the central nervous system (CNS) has been hypothesized.\n\nTo evaluate the presence of delirium in older patients admitted for a suspected diagnosis of COVID-19 and its impact on in-hospital mortality.\n\n91 patients, aged 70-years and older, admitted to an acute geriatric ward in Northern Italy from March 8th to April 17th, 2020.\n\nCOVID-19 cases were confirmed by reverse transcriptase-polymerase chain reaction assay for SARS-Cov-2 RNA from nasal and pharyngeal swabs. Delirium was diagnosed by two geriatricians according to the Diagnostic and Statistical Manual of Mental Disorders V (DMS V) criteria. The number of chronic diseases was calculated among a pre-defined list of 60. The pre-disease Clinical Frailty Scale (CFS) was assessed at hospital admission.\n\nOf the total sample, 39 patients died, 49 were discharged and 3 were transferred to ICU. Twenty-five patients (27.5%) had delirium. Seventy-two percent of patients with delirium died during hospitalization compared to 31.8% of those without delirium. In a multivariate logistic regression model adjusted for potential confounders, patients with delirium were four times more likely to die during hospital stay compared to those without delirium (OR = 3.98;95%CI = 1.05-17.28; p = 0.047).\n\nDelirium is common in older patients with COVID-19 and strongly associated with in-hospital mortality. Regardless of causation, either due to a direct effect of SARS-COV-2 on the CNS or to a multifactorial cause, delirium should be interpreted as an alarming prognostic indicator in older people.", "doi": "10.1093/ageing/afaa189", "pmid": "32821901", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "5894896"}, {"db": "pmc", "key": "PMC7499475"}], "notes": [], "created": "2020-12-04T08:48:39.233Z", "modified": "2021-02-26T08:45:48.468Z"}, {"entity": "publication", "iuid": "c3138d805cb14e17abf439d2118cffb6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3138d805cb14e17abf439d2118cffb6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3138d805cb14e17abf439d2118cffb6"}}, "title": "The COVID-19 pandemic in Norway and Sweden - threats, trust, and impact on daily life: a comparative survey.", "authors": [{"family": "Helsingen", "given": "Lise M", "initials": "LM"}, {"family": "Refsum", "given": "Erle", "initials": "E"}, {"family": "Gj\u00f8stein", "given": "Dagrun Kyte", "initials": "DK"}, {"family": "L\u00f8berg", "given": "Magnus", "initials": "M"}, {"family": "Bretthauer", "given": "Michael", "initials": "M"}, {"family": "Kalager", "given": "Mette", "initials": "M"}, {"family": "Emilsson", "given": "Louise", "initials": "L"}, {"family": "Clinical Effectiveness Research group", "given": "", "initials": ""}], "type": "comparative study", "published": "2020-10-23", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "20", "issue": "1", "pages": "1597"}, "abstract": "Norway and Sweden have similar populations and health care systems, but different reactions to the COVID-19 pandemic. Norway closed educational institutions, and banned sports and cultural activities; Sweden kept most institutions and training facilities open. We aimed to compare peoples' attitudes towards authorities and control measures, and perceived impact of the pandemic and implemented control measures on life in Norway and Sweden.\r\n\r\nAnonymous web-based surveys for individuals age 15 or older distributed through Facebook using the snowball method, in Norway and Sweden from mid-March to mid-April, 2020. The survey contained questions about perceived threat of the pandemic, views on infection control measures, and impact on daily life. We performed descriptive analyses of the responses and compared the two countries.\r\n\r\n3508 individuals participated in the survey (Norway 3000; Sweden 508). 79% were women, the majority were 30-49 years (Norway 60%; Sweden 47%), and about 45% of the participants in both countries had more than 4 years of higher education. Participants had high trust in the health services, but differed in the degree of trust in their government (High trust in Norway 17%; Sweden 37%). More Norwegians than Swedes agreed that school closure was a good measure (Norway 66%; Sweden 18%), that countries with open schools were irresponsible (Norway 65%; Sweden 23%), and that the threat from repercussions of the mitigation measures were large or very large (Norway 71%; Sweden 56%). Both countries had a high compliance with infection preventive measures (> 98%). Many lived a more sedentary life (Norway 69%; Sweden 50%) and ate more (Norway 44%; Sweden 33%) during the pandemic.\r\n\r\nSweden had more trust in the authorities, while Norwegians reported a more negative lifestyle during the pandemic. The level of trust in the health care system and self-reported compliance with preventive measures was high in both countries despite the differences in infection control measures.", "doi": "10.1186/s12889-020-09615-3", "pmid": "33097011", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-020-09615-3"}, {"db": "pmc", "key": "PMC7582026"}], "notes": [], "created": "2020-12-01T15:32:31.149Z", "modified": "2022-11-09T08:44:07.033Z"}, {"entity": "publication", "iuid": "82872c1166474c5fa580ddabf22ed3a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82872c1166474c5fa580ddabf22ed3a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82872c1166474c5fa580ddabf22ed3a6"}}, "title": "Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.", "authors": [{"family": "Zhang", "given": "Qian", "initials": "Q", "orcid": 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"researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4db8bd76f8844446b384a40bcf3ecc74.json"}}, {"family": "Lifton", "given": "Richard P", "initials": "RP"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Gorochov", "given": "Guy", "initials": "G"}, {"family": "B\u00e9ziat", "given": "Vivien", "initials": "V", "orcid": "0000-0002-4020-824X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ec4013e8c1f41d3b3590231e846cfc6.json"}}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E", "orcid": "0000-0002-7358-9157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c50d261245743539a5813daffcaab72.json"}}, {"family": "Sancho-Shimizu", "given": "Vanessa", "initials": "V", "orcid": "0000-0002-3519-0727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9f496e84c0b40d7a38fb4385005ad19.json"}}, {"family": "Rice", "given": "Charles M", "initials": "CM"}, {"family": "Abel", "given": "Laurent", "initials": "L", "orcid": "0000-0001-7016-6493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fd6c4593c8c492a8dad8e49cb7a832a.json"}}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD", "orcid": "0000-0002-8335-0262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3f0c0bf3c294622a95b062a5db4386d.json"}}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5369fe152ac94b5a81d4f913d85940a7.json"}}, {"family": "Su", "given": "Helen C", "initials": "HC", "orcid": "0000-0002-5582-9110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad550813f03540d9a8240a3d96ad0829.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL", "orcid": "0000-0002-7782-4169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1aca66ab7c39465faf2de03fa8a6722f.json"}}], "type": "journal article", "published": "2020-10-23", "journal": {"title": "Science", "issn": "1095-9203", "issn-l": "0036-8075", "volume": "370", "issue": "6515", "pages": "eabd4570"}, "abstract": "Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern Toll-like receptor 3 (TLR3)- and interferon regulatory factor 7 (IRF7)-dependent type I interferon (IFN) immunity to influenza virus in 659 patients with life-threatening COVID-19 pneumonia relative to 534 subjects with asymptomatic or benign infection. By testing these and other rare variants at these 13 loci, we experimentally defined LOF variants underlying autosomal-recessive or autosomal-dominant deficiencies in 23 patients (3.5%) 17 to 77 years of age. We show that human fibroblasts with mutations affecting this circuit are vulnerable to SARS-CoV-2. Inborn errors of TLR3- and IRF7-dependent type I IFN immunity can underlie life-threatening COVID-19 pneumonia in patients with no prior severe infection.", "doi": "10.1126/science.abd4570", "pmid": "32972995", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "mid", "key": "NIHMS1668514"}, {"db": "pmc", "key": "PMC7857407"}, {"db": "pii", "key": "science.abd4570"}, {"db": "Dryad", "key": "10.5061/dryad.8pk0p2nkk"}], "notes": [], "created": "2020-11-11T07:23:46.873Z", "modified": "2023-06-19T15:36:55.110Z"}, {"entity": "publication", "iuid": "1564e27d38eb434197f567c9358d5f37", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1564e27d38eb434197f567c9358d5f37.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1564e27d38eb434197f567c9358d5f37"}}, "title": "How to ventilate obese patients in the ICU.", "authors": [{"family": "De Jong", "given": "Audrey", "initials": "A"}, {"family": "Wrigge", "given": "Hermann", "initials": "H"}, {"family": "Hedenstierna", "given": "Goran", "initials": "G"}, {"family": "Gattinoni", "given": "Luciano", "initials": "L"}, {"family": "Chiumello", "given": "Davide", "initials": "D"}, {"family": "Frat", "given": "Jean-Pierre", "initials": "JP"}, {"family": "Ball", "given": "Lorenzo", "initials": "L"}, {"family": "Schetz", "given": "Miet", "initials": "M"}, {"family": "Pickkers", "given": "Peter", "initials": "P"}, {"family": "Jaber", "given": "Samir", "initials": "S"}], "type": "journal article", "published": "2020-10-23", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "volume": "46", "issue": "12", "pages": "2423-2435", "issn-l": "0342-4642"}, "abstract": "Obesity is an important risk factor for major complications, morbidity and mortality related to intubation procedures and ventilation in the intensive care unit (ICU). The fall in functional residual capacity promotes airway closure and atelectasis formation. This narrative review presents the impact of obesity on the respiratory system and the key points to optimize airway management, noninvasive and invasive mechanical ventilation in ICU patients with obesity. Non-invasive strategies should first optimize body position with reverse Trendelenburg position or sitting position. Noninvasive ventilation (NIV) is considered as the first-line therapy in patients with obesity having a postoperative acute respiratory failure. Positive pressure pre-oxygenation before the intubation procedure is the method of reference. The use of videolaryngoscopy has to be considered by adequately trained intensivists, especially in patients with several risk factors. Regarding mechanical ventilation in patients with and without acute respiratory distress syndrome (ARDS), low tidal volume (6 ml/kg of predicted body weight) and moderate to high positive end-expiratory pressure (PEEP), with careful recruitment maneuver in selected patients, are advised. Prone positioning is a therapeutic choice in severe ARDS patients with obesity. Prophylactic NIV should be considered after extubation to prevent re-intubation. If obesity increases mortality and risk of ICU admission in the overall population, the impact of obesity on ICU mortality is less clear and several confounding factors have to be taken into account regarding the \"obesity ICU paradox\".", "doi": "10.1007/s00134-020-06286-x", "pmid": "33095284", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-020-06286-x"}, {"db": "pmc", "key": "PMC7582031"}], "notes": [], "created": "2020-11-27T11:47:55.408Z", "modified": "2020-12-01T15:34:43.643Z"}, {"entity": "publication", "iuid": "f321360c50fe488b82ebe569db5f796d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f321360c50fe488b82ebe569db5f796d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f321360c50fe488b82ebe569db5f796d"}}, "title": "Autoantibodies against type I IFNs in patients with life-threatening COVID-19.", "authors": [{"family": "Bastard", "given": "Paul", "initials": "P", "orcid": 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{"family": "Zhang", "given": "Yu", "initials": "Y"}, {"family": "Dorgham", "given": "Karim", "initials": "K", "orcid": "0000-0001-9539-3203", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/343687bcbc014c7880ce47bfc772c00c.json"}}, {"family": "Philippot", "given": "Quentin", "initials": "Q"}, {"family": "Rosain", "given": "J\u00e9r\u00e9mie", "initials": "J"}, {"family": "B\u00e9ziat", "given": "Vivien", "initials": "V", "orcid": "0000-0002-4020-824X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ec4013e8c1f41d3b3590231e846cfc6.json"}}, {"family": "Manry", "given": "J\u00e9r\u00e9my", "initials": "J", "orcid": "0000-0001-5998-2051", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba0f830e329042efa24e0bb5bb8dd752.json"}}, {"family": "Shaw", "given": "Elana", "initials": "E", "orcid": "0000-0001-9265-8026", "researcher": {"href": 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"initials": "D", "orcid": "0000-0002-4571-044X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/472ec24aef0a4a81bd7f3372c21c5b01.json"}}, {"family": "Roussel", "given": "Lucie", "initials": "L", "orcid": "0000-0001-5355-702X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7edbf1a2fe08414d9259e6dd3adcd24e.json"}}, {"family": "Vinh", "given": "Donald C", "initials": "DC", "orcid": "0000-0003-1347-7767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d08bd304d9d43d980914472fa294316.json"}}, {"family": "Tangye", "given": "Stuart G", "initials": "SG", "orcid": "0000-0002-5360-5180", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58d0bf707fc24c139e36ac3d79ced381.json"}}, {"family": "Haerynck", "given": "Filomeen", "initials": "F"}, {"family": "Dalmau", "given": "David", "initials": "D", "orcid": "0000-0003-1936-478X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b04eafe2908b4f758dc3756c852bb794.json"}}, {"family": "Martinez-Picado", "given": "Javier", "initials": "J", "orcid": "0000-0002-4916-2129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d7db939b60d47999925369948f30e2b.json"}}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}, {"family": "Nussenzweig", "given": "Michel C", "initials": "MC", "orcid": "0000-0003-0592-8564", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e61ea4596aea42f290126607bd74c2b9.json"}}, {"family": "Boisson-Dupuis", "given": "St\u00e9phanie", "initials": "S", "orcid": "0000-0002-7115-116X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92c785f151bb490aa85764eb62c0508e.json"}}, {"family": "Rodr\u00edguez-Gallego", "given": "Carlos", "initials": "C", "orcid": "0000-0002-4344-8644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6c66da3a09c42d7925056c90bddedee.json"}}, {"family": "Vogt", "given": "Guillaume", "initials": "G"}, {"family": "Mogensen", "given": "Trine H", "initials": "TH", "orcid": "0000-0002-1853-9704", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/afec82740890482f8b617acee51d2401.json"}}, {"family": "Oler", "given": "Andrew J", "initials": "AJ", "orcid": "0000-0002-6310-0434", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/339a50f3711e47cb97f705498dc4e9da.json"}}, {"family": "Gu", "given": "Jingwen", "initials": "J"}, {"family": "Burbelo", "given": "Peter D", "initials": "PD", "orcid": "0000-0003-1717-048X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/caf17d6e254746ea8dc72213bcc6f65a.json"}}, {"family": "Cohen", "given": "Jeffrey I", "initials": "JI", "orcid": "0000-0003-0238-7176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f4b3e2ddf0dd40aca09dcdcb2cc7254f.json"}}, {"family": "Biondi", "given": "Andrea", "initials": "A"}, {"family": "Bettini", "given": "Laura Rachele", "initials": "LR", "orcid": "0000-0002-0280-1704", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b40303f53284f60bf2ec5b774831ae6.json"}}, {"family": "D'Angio", "given": "Mariella", "initials": "M"}, {"family": "Bonfanti", "given": "Paolo", "initials": "P", "orcid": "0000-0001-7289-8823", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52b16f4f4f5c4031a8435f6f17e791c7.json"}}, {"family": "Rossignol", "given": "Patrick", "initials": "P"}, {"family": "Mayaux", "given": "Julien", "initials": "J"}, {"family": "Rieux-Laucat", "given": "Fr\u00e9d\u00e9ric", "initials": "F", "orcid": "0000-0001-7858-7866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25490c3f0b9b4c299c3d6ae9e52faffb.json"}}, {"family": "Husebye", "given": "Eystein S", "initials": "ES", "orcid": "0000-0002-7886-2976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a6afa5e34f74d3db1aa66a6afef9724.json"}}, {"family": "Fusco", "given": "Francesca", "initials": "F"}, {"family": "Ursini", "given": "Matilde Valeria", "initials": "MV"}, {"family": "Imberti", "given": "Luisa", "initials": "L"}, {"family": "Sottini", "given": "Alessandra", "initials": "A"}, {"family": "Paghera", "given": "Simone", "initials": "S"}, {"family": "Quiros-Roldan", "given": "Eugenia", "initials": "E"}, {"family": "Rossi", "given": "Camillo", "initials": "C"}, {"family": "Castagnoli", "given": "Riccardo", "initials": "R", "orcid": "0000-0003-0029-9383", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc5b8149bfc34cc99d00f67c27b0d31f.json"}}, {"family": "Montagna", "given": "Daniela", "initials": "D"}, {"family": "Licari", "given": "Amelia", "initials": "A", "orcid": "0000-0002-1773-6482", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a39e2bbc5714bd78cc6e9116a18143b.json"}}, {"family": "Marseglia", "given": "Gian Luigi", "initials": "GL"}, {"family": "Duval", "given": "Xavier", "initials": "X"}, {"family": "Ghosn", "given": "Jade", "initials": "J"}, {"family": "HGID Lab", "given": "", "initials": ""}, {"family": "NIAID-USUHS Immune Response to COVID Group", "given": "", "initials": ""}, {"family": "COVID Clinicians", "given": "", "initials": ""}, {"family": "COVID-STORM Clinicians", "given": "", "initials": ""}, {"family": "Imagine COVID Group", "given": "", "initials": ""}, {"family": "French COVID Cohort Study Group", "given": "", "initials": ""}, {"family": "Milieu Int\u00e9rieur Consortium", "given": "", "initials": ""}, {"family": "CoV-Contact Cohort", "given": "", "initials": ""}, {"family": "Amsterdam UMC Covid-19 Biobank", "given": "", "initials": ""}, {"family": "COVID Human Genetic Effort", "given": "", "initials": ""}, {"family": "Tsang", "given": "John S", "initials": "JS", "orcid": "0000-0003-3186-3047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c9f3d88b94c4754b5fa887e3f29553b.json"}}, {"family": "Goldbach-Mansky", "given": "Raphaela", "initials": "R", "orcid": "0000-0001-7865-5769", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35abe088a9fa478c9bf9c2e1f18a3e1d.json"}}, {"family": "Kisand", "given": "Kai", "initials": "K", "orcid": "0000-0002-5426-4648", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45ab722bd98b4f23a99c3f07f0ecfa2c.json"}}, {"family": "Lionakis", "given": "Michail S", "initials": "MS"}, {"family": "Puel", "given": "Anne", "initials": "A", "orcid": "0000-0003-2603-0323", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2bdac14a1d14b8496ffd12dac6df3e5.json"}}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Holland", "given": "Steven M", "initials": "SM", "orcid": "0000-0003-3207-5464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12c5a29018ef487eb1e09ca7bba4cae6.json"}}, {"family": "Gorochov", "given": "Guy", "initials": "G"}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E", "orcid": "0000-0002-7358-9157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c50d261245743539a5813daffcaab72.json"}}, {"family": "Rice", "given": "Charles M", "initials": "CM"}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5369fe152ac94b5a81d4f913d85940a7.json"}}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD", "orcid": "0000-0002-8335-0262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3f0c0bf3c294622a95b062a5db4386d.json"}}, {"family": "Abel", "given": "Laurent", "initials": "L", "orcid": "0000-0001-7016-6493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fd6c4593c8c492a8dad8e49cb7a832a.json"}}, {"family": "Su", "given": "Helen C", "initials": "HC", "orcid": "0000-0002-5582-9110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad550813f03540d9a8240a3d96ad0829.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL", "orcid": "0000-0002-7782-4169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1aca66ab7c39465faf2de03fa8a6722f.json"}}], "type": "journal article", "published": "2020-10-23", "journal": {"title": "Science", "issn": "1095-9203", "issn-l": "0036-8075", "volume": "370", "issue": "6515", "pages": null}, "abstract": "Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-\u03c9 (IFN-\u03c9) (13 patients), against the 13 types of IFN-\u03b1 (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.", "doi": "10.1126/science.abd4585", "pmid": "32972996", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "mid", "key": "NIHMS1668509"}, {"db": "pmc", "key": "PMC7857397"}, {"db": "pii", "key": "science.abd4585"}], "notes": [], "created": "2020-10-28T08:38:59.426Z", "modified": "2023-06-19T15:37:11.302Z"}, {"entity": "publication", "iuid": "960e677d9dea43468a52138dcc29ff17", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/960e677d9dea43468a52138dcc29ff17.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/960e677d9dea43468a52138dcc29ff17"}}, "title": "Abortion regulation in Europe in the era of COVID-19: a spectrum of policy responses.", "authors": [{"family": "Moreau", "given": "Caroline", "initials": "C"}, {"family": "Shankar", "given": "Mridula", "initials": "M"}, {"family": "Glasier", "given": "Anna", "initials": "A"}, {"family": "Cameron", "given": "Sharon", "initials": "S"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}], "type": "journal article", "published": "2020-10-22", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-2009", "volume": null, "issue": null, "issn-l": "2515-1991"}, "abstract": "Unprecedented public health actions restricting movement and non-COVID related health services are likely to have affected abortion care during the pandemic in Europe. In the absence of a common approach to ensure access to this essential health service, we sought to describe the variability of abortion policies during the outbreak in Europe in order to identify strategies that improve availability and access to abortion in times of public health crises.\n\nWe collected information from 46 countries/regions: 31 for which country-experts completed a survey and 15 for which we conducted a desk review. We describe abortion regulations and changes to regulations and practice during the pandemic.\n\nDuring COVID-19, abortions were banned in six countries and suspended in one. Surgical abortion was less available due to COVID-19 in 12 countries/regions and services were not available or delayed for women with COVID-19 symptoms in eleven. No country expanded its gestational limit for abortion. Changes during COVID-19, mostly designed to reduce in-person consultations, occurred in 13 countries/regions. Altogether eight countries/regions provided home medical abortion with mifepristone and misoprostol beyond 9 weeks (from 9 weeks+6 days to 11 weeks+6 days) and 13 countries/regions up to 9 weeks (in some instances only misoprostol could be taken at home). Only six countries/regions offered abortion by telemedicine.\n\nThe lack of a unified policy response to COVID-19 restrictions has widened inequities in abortion access in Europe, but some innovations including telemedicine deployed during the outbreak could serve as a catalyst to ensure continuity and equity of abortion care.", "doi": "10.1136/bmjsrh-2020-200724", "pmid": "33093040", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjsrh-2020-200724"}], "notes": [], "created": "2020-11-26T12:30:40.338Z", "modified": "2020-12-01T15:37:55.328Z"}, {"entity": "publication", "iuid": "ff7d25c1af0a44379275ecec7e145449", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff7d25c1af0a44379275ecec7e145449.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff7d25c1af0a44379275ecec7e145449"}}, "title": "Serum-IgG responses to SARS-CoV-2 after mild and severe COVID-19 infection and analysis of IgG non-responders.", "authors": [{"family": "Marklund", "given": "Emelie", "initials": "E"}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Axelsson", "given": "Hannes", "initials": "H"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Norder", "given": "Hel\u00e9ne", "initials": "H"}, {"family": "Bemark", "given": "Mats", "initials": "M"}, {"family": "Angeletti", "given": "Davide", "initials": "D"}, {"family": "Lundgren", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Andersson", "given": "Lars Magnus", "initials": "LM"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Liljeqvist", "given": "Jan \u00c5ke", "initials": "J\u00c5"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2020-10-21", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "15", "issue": "10", "pages": "e0241104"}, "abstract": "To accurately interpret COVID-19 seroprevalence surveys, knowledge of serum-IgG responses to SARS-CoV-2 with a better understanding of patients who do not seroconvert, is imperative. This study aimed to describe serum-IgG responses to SARS-CoV-2 in a cohort of patients with both severe and mild COVID-19, including extended studies of patients who remained seronegative more than 90 days post symptom onset.\r\n\r\nSARS-CoV-2-specific IgG antibody levels were quantified using two clinically validated and widely used commercial serological assays (Architect, Abbott Laboratories and iFlash 1800, YHLO), detecting antibodies against the spike and nucleocapsid proteins.\r\n\r\nForty-seven patients (mean age 49 years, 38% female) were included. All (15/15) patients with severe symptoms and 29/32 (90.6%) patients with mild symptoms of COVID-19 developed SARS-CoV-2-specific IgG antibodies in serum. Time to seroconversion was significantly shorter (median 11 vs. 22 days, P = 0.04) in patients with severe compared to mild symptoms. Of the three patients without detectable IgG-responses after >90 days, all had detectable virus-neutralizing antibodies and in two, spike-protein receptor binding domain-specific IgG was detected with an in-house assay. Antibody titers were preserved during follow-up and all patients who seroconverted, irrespective of the severity of symptoms, still had detectable IgG levels >75 days post symptom onset.\r\n\r\nPatients with severe COVID-19 both seroconvert earlier and develop higher concentrations of SARS-CoV-2-specific IgG than patients with mild symptoms. Of those patients who not develop detectable IgG antibodies, all have detectable virus-neutralizing antibodies, suggesting immunity. Our results showing that not all COVID-19 patients develop detectable IgG using two validated commercial clinical methods, even over time, are vital for the interpretation of COVID-19 seroprevalence surveys.", "doi": "10.1371/journal.pone.0241104", "pmid": "33085715", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Research Area: Drug discovery and repurposing of drugs": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Biomarkers and systems immunology": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.5281/zenodo.3934336", "description": "https://doi.org/10.5281/zenodo.3934336"}], "notes": [], "created": "2020-10-30T11:44:05.878Z", "modified": "2022-02-14T07:47:22.475Z"}, {"entity": "publication", "iuid": "bfa69afc506849d699357613bce49a49", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bfa69afc506849d699357613bce49a49.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bfa69afc506849d699357613bce49a49"}}, "title": "Digital contact tracing and exposure notification: ethical guidance for trustworthy pandemic management.", "authors": [{"family": "Ranisch", "given": "Robert", "initials": "R"}, {"family": "Nijsingh", "given": "Niels", "initials": "N"}, {"family": "Ballantyne", "given": "Angela", "initials": "A"}, {"family": "van Bergen", "given": "Anne", "initials": "A"}, {"family": "Buyx", "given": "Alena", "initials": "A"}, {"family": "Friedrich", "given": "Orsolya", "initials": "O"}, {"family": "Hendl", "given": "Tereza", "initials": "T"}, {"family": "Marckmann", "given": "Georg", "initials": "G"}, {"family": "Munthe", "given": "Christian", "initials": "C"}, {"family": "Wild", "given": "Verina", "initials": "V"}], "type": "journal article", "published": "2020-10-21", "journal": {"title": "Ethics Inf Technol", "issn": "1388-1957", "volume": null, "issue": null, "pages": "1-10", "issn-l": null}, "abstract": "There is growing interest in contact tracing apps (CT apps) for pandemic management. It is crucial to consider ethical requirements before, while, and after implementing such apps. In this paper, we illustrate the complexity and multiplicity of the ethical considerations by presenting an ethical framework for a responsible design and implementation of CT apps. Using this framework as a starting point, we briefly highlight the interconnection of social and political contexts, available measures of pandemic management, and a multi-layer assessment of CT apps. We will discuss some trade-offs that arise from this perspective. We then suggest that public trust is of major importance for population uptake of contact tracing apps. Hasty, ill-prepared or badly communicated implementations of CT apps will likely undermine public trust, and as such, risk impeding general effectiveness.", "doi": "10.1007/s10676-020-09566-8", "pmid": "33106749", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "9566"}, {"db": "pmc", "key": "PMC7577205"}], "notes": [], "created": "2020-12-01T15:24:55.558Z", "modified": "2020-12-01T15:25:07.393Z"}, {"entity": "publication", "iuid": "6be39116f72544b68d8d9dc7977d08a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6be39116f72544b68d8d9dc7977d08a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6be39116f72544b68d8d9dc7977d08a6"}}, "title": "International Sexual Health And REproductive health (I-SHARE) survey during COVID-19: study protocol for online national surveys and global comparative analyses.", "authors": [{"family": "Michielsen", "given": "Kristien", "initials": "K"}, {"family": "Larrson", "given": "Elin C", "initials": "EC"}, {"family": "K\u00e5gesten", "given": "Anna", "initials": "A"}, {"family": "Erausquin", "given": "Jennifer Toller", "initials": "JT"}, {"family": "Griffin", "given": "Sally", "initials": "S"}, {"family": "Van de Velde", "given": "Sarah", "initials": "S"}, {"family": "Tucker", "given": "Joseph D", "initials": "JD"}, {"family": "I-SHARE Team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-10-20", "journal": {"title": "Sex Transm Infect", "issn": "1472-3263", "volume": null, "issue": null, "issn-l": "1368-4973"}, "abstract": "COVID-19 may have a profound impact on sexual health, reproductive health and social life across the world. Shelter in place regulations that have extended across the globe may influence condomless sex, exacerbate intimate partner violence and reduce access to essential reproductive health services. Population representative research is challenging during shelter in place, leaving major gaps in our understanding of sexual and reproductive health during COVID-19. This International Sexual Health And ReproductivE health (I-SHARE) study protocol manuscript describes a common plan for online national surveys and global comparative analyses.\n\nThe purpose of this cross-sectional study is to better understand sexual and reproductive health in selected countries during the COVID-19 pandemic and facilitate multinational comparisons. Participants will be recruited through an online survey link disseminated through local, regional and national networks. In each country, a lead organisation will be responsible for organising ethical review, translation and survey administration. The consortium network provides support for national studies, coordination and multinational comparison. We will use multilevel modelling to determine the relationship between COVID-19 and condomless sex, intimate partner violence, access to reproductive health services, HIV testing and other key items. This study protocol defines primary outcomes, prespecified subanalyses and analysis plans.\n\nThe I-SHARE study examines sexual and reproductive health at the national and global level during the COVID-19 pandemic. We will use multilevel modelling to investigate country-level variables associated with outcomes of interest. This will provide a foundation for subsequent online multicountry comparison using more robust sampling methodologies.", "doi": "10.1136/sextrans-2020-054664", "pmid": "33082232", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "sextrans-2020-054664"}], "notes": [], "created": "2020-11-26T12:36:06.646Z", "modified": "2020-12-01T15:41:25.096Z"}, {"entity": "publication", "iuid": "3770f7604a374d3992aa913a910ac25d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3770f7604a374d3992aa913a910ac25d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3770f7604a374d3992aa913a910ac25d"}}, "title": "COVID-19 outbreak-related psychological distress among healthcare trainees: a cross-sectional study in China.", "authors": [{"family": "Wang", "given": "Yue", "initials": "Y"}, {"family": "Li", "given": "Yuchen", "initials": "Y"}, {"family": "Jiang", "given": "Jingwen", "initials": "J"}, {"family": "Feng", "given": "Yuying", "initials": "Y"}, {"family": "Lu", "given": "Donghao", "initials": "D"}, {"family": "Zhang", "given": "Wei", "initials": "W"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "journal article", "published": "2020-10-20", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "10", "issue": "10", "pages": "e041671"}, "abstract": "The COVID-19 outbreak has caused enormous strain on healthcare systems, and healthcare trainees, which comprise the future healthcare workforce, may be a vulnerable group. It is essential to assess the psychological distress experienced by healthcare trainees during the COVID-19 outbreak.\r\n\r\nA cross-sectional study with 4184 healthcare trainees at Sichuan University in China was implemented during 7-13 February 2020. Participants were grouped by training programmes (medicine, medical technology and nursing) and training stages (undergraduate, postgraduate and residency).\r\n\r\nCOVID-19-related psychological distress and acute stress reaction (ASR) were assessed using the Kessler 6-item Psychological Distress Scale and the Impact of Event Scale-Revised, respectively. We estimated the ORs of distress by comparing trainees across programmes and training stages using multivariable logistic regression.\r\n\r\nSignificant psychological distress was found in 1150 (30.90%) participants and probable ASR in 403 (10.74%). Compared with the nursing trainees, the medical trainees (OR 1.54, 95% CI 1.22 to 1.95) reported a higher burden of psychological distress during the outbreak, while the medical technology trainees (OR 1.25, 95% CI 0.97 to 1.62) reported similar symptom scores. Postgraduates (OR 1.55, 95% CI 1.16 to 2.08) in medicine had higher levels of distress than their undergraduate counterparts did, whereas the nursing residents (OR 0.38, 95% CI 0.20 to 0.71) reported a lower burden than did nursing undergraduates. A positive association was found between having active clinical duties during the outbreak and distress (OR 1.17, 95% CI 0.98 to 1.39), particularly among the medical trainees (OR 1.85, 95% CI 1.47 to 2.33) and undergraduates (OR 4.20, 95% CI 1.61 to 11.70). No clear risk patterns of ASR symptoms were observed.\r\n\r\nMedical trainees, particularly postgraduates and those with active clinical duties, were at risk for psychological distress during the COVID-19 outbreak. Stress management may be considered for high-risk healthcare trainees.", "doi": "10.1136/bmjopen-2020-041671", "pmid": "33082197", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-041671"}, {"db": "pmc", "key": "PMC7577057"}], "notes": [], "created": "2020-12-01T15:42:02.339Z", "modified": "2022-11-09T08:45:01.712Z"}, {"entity": "publication", "iuid": "9184c2b13df3405285a42ea6ea4c942a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9184c2b13df3405285a42ea6ea4c942a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9184c2b13df3405285a42ea6ea4c942a"}}, "title": "Refugees in Sweden During the Covid-19 Pandemic-The Need for a New Perspective on Health and Integration.", "authors": [{"family": "Elisabeth", "given": "Mangrio", "initials": "M"}, {"family": "Maneesh", "given": "Paul-Satyaseela", "initials": "PS"}, {"family": "Michael", "given": "Strange", "initials": "S"}], "type": "journal article", "published": "2020-10-19", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "574334", "issn-l": "2296-2565"}, "abstract": "Refugees are already a vulnerable group in society and are in a stressful situation due to their often uncertain legal status in seeking asylum and integration in the new society after migration. Refugees are, in general, at greater risk of poor health outcomes when contracting Covid-19, exacerbated by poor living conditions and difficulties in accessing healthcare. The longer-term social consequences of the pandemic also disproportionately impact refugees, including social isolation, unemployment, and difficulties to obtain correct health information. The aim of this paper is to review the social and health consequences that Covid-19 has brought to the refugees residing in Sweden. This needs to be emphasized in order to mitigate against these likely consequences and improve the overall well-being among such a highly vulnerable group in society. As Covid-19 demonstrates, human health needs to be understood holistically, meaning that the vulnerability of any individuals, or even nations, is a vulnerability for the whole population requiring urgent action.", "doi": "10.3389/fpubh.2020.574334", "pmid": "33194974", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7604301"}], "notes": [], "created": "2020-11-27T11:01:13.351Z", "modified": "2023-01-13T13:52:25.482Z"}, {"entity": "publication", "iuid": "9aed2029c548476eae887740c14ca236", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9aed2029c548476eae887740c14ca236.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9aed2029c548476eae887740c14ca236"}}, "title": "Management of patients with chronic rhinosinusitis during the COVID-19 pandemic - An EAACI Position Paper.", "authors": [{"family": "Klimek", "given": "L", "initials": "L"}, {"family": "Jutel", "given": "M", "initials": "M"}, {"family": "Bousquet", "given": "J", "initials": "J"}, {"family": "Agache", "given": "I", "initials": "I"}, {"family": "Akdis", "given": "C", "initials": "C"}, {"family": "Hox", "given": "V", "initials": "V"}, {"family": "Gevaert", "given": "P", "initials": "P"}, {"family": "Tomazic", "given": "P V", "initials": "PV"}, {"family": "Rondon", "given": "C", "initials": "C"}, {"family": "Cingi", "given": "C", "initials": "C"}, {"family": "Toppila-Salmi", "given": "S", "initials": "S"}, {"family": "Karavelia", "given": "A", "initials": "A"}, {"family": "Bozkurt", "given": "B", "initials": "B"}, {"family": "F\u00f6rster-Ruhrmann", "given": "U", "initials": "U"}, {"family": "Becker", "given": "S", "initials": "S"}, {"family": "Chaker", "given": "A M", "initials": "AM"}, {"family": "Wollenberg", "given": "B", "initials": "B"}, {"family": "M\u00f6sges", "given": "R", "initials": "R"}, {"family": "Huppertz", "given": "T", "initials": "T"}, {"family": "Hagemann", "given": "J", "initials": "J"}, {"family": "Bachert", "given": "C", "initials": "C"}, {"family": "Fokkens", "given": "W", "initials": "W"}], "type": "journal article", "published": "2020-10-19", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": null, "issue": null, "issn-l": "0105-4538"}, "abstract": "CRS is regarded as a chronic airway disease. According to WHO recommendations, it may be a risk factor for COVID-19 patients. In most CRSwNP cases, the inflammatory changes affecting the nasal and paranasal mucous membranes are type-2 (T2) inflammation endotypes.\n\nThe current knowledge on COVID-19 and on treatment options for CRS was analyzed by a literature search in Medline, Pubmed, international guidelines, the Cochrane Library and the Internet.\n\nBased on international literature, on current recommendations by WHO and other international organizations as well as on previous experience, a panel of experts from EAACI and ARIA provided recommendations for the treatment of CRS during the COVID-19 pandemic.\n\nIntranasal corticosteroids remain the standard treatment for CRS in patients with SARS-CoV-2 infection. Surgical treatments should be reduced to a minimum and surgery preserved for patients with local complications and for those with no other treatment options. Systemic corticosteroids should be avoided. Treatment with biologics can be continued with careful monitoring in non-infected patients and should be temporarily interrupted during the course of the COVID-19 infection.", "doi": "10.1111/all.14629", "pmid": "33075144", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-01T16:58:38.839Z", "modified": "2020-12-01T16:58:38.850Z"}, {"entity": "publication", "iuid": "05886c693526485f80fe8f4503151ef0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/05886c693526485f80fe8f4503151ef0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/05886c693526485f80fe8f4503151ef0"}}, "title": "Effect of COVID-19 pandemic on treatment of Type 1 diabetes in children.", "authors": [{"family": "Ludvigsson", "given": "Johnny", "initials": "J"}], "type": "journal article", "published": "2020-10-19", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": null, "issue": null, "pages": null}, "abstract": "Brief report", "doi": "10.1111/apa.15627", "pmid": "33073367", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-01T16:59:59.808Z", "modified": "2020-12-01T17:00:40.121Z"}, {"entity": "publication", "iuid": "70d4934c27434293805e8ae5fb7722b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70d4934c27434293805e8ae5fb7722b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70d4934c27434293805e8ae5fb7722b4"}}, "title": "Antibody responses to SARS-CoV-2 train machine learning to assign likelihood of past infection during virus emergence in Sweden", "authors": [{"family": "Castro Dopico", "given": "Xaqu\u00edn", "initials": "X"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Sheward", "given": "Daniel J.", "initials": "DJ"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Christian", "given": "Murray", "initials": "M"}, {"family": "Grinberg", "given": "Nastasiya F.", "initials": "NF"}, {"family": "Adori", "given": "Monika", "initials": "M"}, {"family": "Perez Vidakovics", "given": "Laura", "initials": "L"}, {"family": "Kim", "given": "ChangIl", "initials": "C"}, {"family": "Khoenkhoen", "given": "Sharesta", "initials": "S"}, {"family": "Pushparaj", "given": "Pradeepa", "initials": "P"}, {"family": "Moliner Morro", "given": "Ainhoa", "initials": "A"}, {"family": "Mandolesi", "given": "Marco", "initials": "M"}, {"family": "Ahl", "given": "Marcus", "initials": "M"}, {"family": "Forsell", "given": "Mattias", "initials": "M"}, {"family": "Coquet", "given": "Jonathan", "initials": "J"}, {"family": "Corcoran", "given": "Martin", "initials": "M"}, {"family": "Rorbach", "given": "Joanna", "initials": "J"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Allander", "given": "Tobias", "initials": "T"}, {"family": "Wallace", "given": "Chris", "initials": "C"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Karlsson Hedestam", "given": "Gunilla B.", "initials": "GB"}], "type": "posted-content", "published": "2020-10-19", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Serology is critical for understanding pathogen-specific immune responses, but is fraught with difficulty, not least because the strength of antibody (Ab) response varies greatly between individuals and mild infections generally generate lower Ab titers (1-3). We used robust IgM, IgG and IgA Ab tests to evaluate anti-SARS-CoV-2 responses in individuals PCR+ for virus RNA (n=105) representing different categories of disease severity, including mild cases. All PCR+ individuals in the study became IgG-positive against pre-fusion trimers of the virus spike (S) glycoprotein, but titers varied greatly. Elevated IgA, IL-6 and neutralizing responses were present in intensive care patients. Additionally, blood donors and pregnant women (n=2,900) sampled throughout the first wave of the pandemic in Stockholm, Sweden, further demonstrated that anti-S IgG titers differed several orders of magnitude between individuals, with an increase of low titer values present in the population at later time points (4,5). To improve upon current methods to identify low titers and extend the utility of individual measures (6,7), we used our PCR+ individual data to train machine learning algorithms to assign likelihood of past infection. Using these tools that assigned probability to individual responses against S and the receptor binding domain (RBD), we report SARS-CoV-2-specific IgG in 13.7% of healthy donors five months after the peak of spring COVID-19 deaths, when mortality and ICU occupancy in the country due to the virus were at low levels. These data further our understanding of antibody responses to the virus and provide solutions to problems in serology data analysis.", "doi": "10.1101/2020.07.17.20155937", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://github.com/MurrellGroup/DiscriminativeSeroprevalence/", "description": "Inferring seroprevalence from ELISA data, without choosing a cutoff"}], "notes": [], "created": "2020-10-30T11:57:22.549Z", "modified": "2021-02-26T08:45:48.314Z"}, {"entity": "publication", "iuid": "925bb496b0f3481989389b307f005704", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/925bb496b0f3481989389b307f005704.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/925bb496b0f3481989389b307f005704"}}, "title": "Food Sovereignty of the Indigenous Peoples in the Arctic Zone of Western Siberia: Response to COVID-19 Pandemic.", "authors": [{"family": "Bogdanova", "given": "Elena", "initials": "E"}, {"family": "Andronov", "given": "Sergei", "initials": "S"}, {"family": "Morell", "given": "Ildiko Asztalos", "initials": "IA"}, {"family": "Hossain", "given": "Kamrul", "initials": "K"}, {"family": "Raheem", "given": "Dele", "initials": "D"}, {"family": "Filant", "given": "Praskovia", "initials": "P"}, {"family": "Lobanov", "given": "Andrey", "initials": "A"}], "type": "journal article", "published": "2020-10-18", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "20", "pages": null}, "abstract": "This article presents the challenges facing reindeer herding as being both a profitable business and part of the traditional culture of the nomadic Indigenous peoples in the Arctic zone of Western Siberia which addresses substantial needs of the local population. Reindeer herding products are used as traditional nutrition, and as effective preventive means and remedies for adapting to the cold and geomagnetic activity in the High North. Export trends of traditional reindeer products have decreased local Indigenous peoples' access to venison and had a negative impact on their health. Due to the COVID-19 pandemic, it is especially urgent for the Indigenous peoples to have sufficient access to traditional food and be involved in policy decision-making to maintain this traditional business. We aim to analyze the dependencies of Indigenous peoples on the reindeer produce-exporting \"food value chain\" and explore how (1) the independence of reindeer herders could be increased in these export chains and (2) how provision of their products to local communities could be secured. The study takes a multidisciplinary approach based on policy and socioeconomic analyses with input from medical research. Primary sources include data collected from interviews and surveys of Indigenous peoples during expeditions to the Nyda settlement, the Nydinskaya tundra, the Tazovsky settlement, the Tazovskaya tundra, the Nakhodka tundra, the Gyda and Gydansky settlements, the Yavai-Salinskaya tundra, the Seyakha settlement, the Seyakhinskaya and Tambeyskaya tundras located along the southern coast of the Ob Bay, the northeast coast of the Yamal Peninsula, the Tazovsky and Gydansky Peninsulas, and the Shuryshkarsky district. Data were collected during the summers and winters of 2014-2020.", "doi": "10.3390/ijerph17207570", "pmid": "33080982", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph17207570"}, {"db": "pmc", "key": "PMC7590208"}], "notes": [], "created": "2020-12-01T15:43:25.508Z", "modified": "2022-11-09T08:46:54.157Z"}, {"entity": "publication", "iuid": "267f1fcb0fb34478bf52e2fd9db96cd2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/267f1fcb0fb34478bf52e2fd9db96cd2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/267f1fcb0fb34478bf52e2fd9db96cd2"}}, "title": "Estimating total excess mortality during a COVID-19 outbreak in Stockholm, Sweden.", "authors": [{"family": "Pimenoff", "given": "Ville N", "initials": "VN"}, {"family": "Elfstr\u00f6m", "given": "Miriam", "initials": "M"}, {"family": "Baussano", "given": "Iacopo", "initials": "I"}, {"family": "Bj\u00f6rnstedt", "given": "Mikael", "initials": "M"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}], "type": "journal article", "published": "2020-10-18", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "issn-l": "1058-4838", "volume": null, "issue": null, "pages": null}, "abstract": "Total excess mortality peaked during a COVID19 outbreak in Stockholm, but 25% of these deaths were not recognized as Covid-19-related nor occurred in hospitals. Estimate of total excess mortality may give a more comprehensive picture of the total disease burden during a COVID19 outbreak, and may facilitate managing future outbreaks.", "doi": "10.1093/cid/ciaa1593", "pmid": "33070183", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "5929661"}, {"db": "pmc", "key": "PMC7665438"}], "notes": [], "created": "2020-11-18T16:48:58.988Z", "modified": "2021-02-26T08:45:47.953Z"}, {"entity": "publication", "iuid": "cfa37a55e8fc473d9a1938b3d880e236", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfa37a55e8fc473d9a1938b3d880e236.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfa37a55e8fc473d9a1938b3d880e236"}}, "title": "The COVID-19 pandemic and serious psychological consequences in Bangladesh: A population-based nationwide study.", "authors": [{"family": "Mamun", "given": "Mohammed A", "initials": "MA"}, {"family": "Sakib", "given": "Najmuj", "initials": "N"}, {"family": "Gozal", "given": "David", "initials": "D"}, {"family": "Bhuiyan", "given": "Akm Israfil", "initials": "AI"}, {"family": "Hossain", "given": "Sahadat", "initials": "S"}, {"family": "Bodrud-Doza", "given": "Md", "initials": "M"}, {"family": "Al Mamun", "given": "Firoj", "initials": "F"}, {"family": "Hosen", "given": "Ismail", "initials": "I"}, {"family": "Safiq", "given": "Mariam Binte", "initials": "MB"}, {"family": "Abdullah", "given": "Abu Hasnat", "initials": "AH"}, {"family": "Sarker", "given": "Md Abedin", "initials": "MA"}, {"family": "Rayhan", "given": "Istihak", "initials": "I"}, {"family": "Sikder", "given": "Md Tajuddin", "initials": "MT"}, {"family": "Muhit", "given": "Mohammad", "initials": "M"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2020-10-17", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "issn-l": null, "volume": "279", "issue": null, "pages": "462-472"}, "abstract": "As with other countries worldwide, lockdown measures during the COVID-19 outbreak in Bangladesh were sudden and unexpected, and have the capacity to elicit serious psychological consequences. The present study examined the psychological consequences of COVID-19 in Bangladesh during the lockdown period.\r\n\r\nA nationwide online cross-sectional survey study recruited 10,067 individuals covering all 64 districts in Bangladesh via social media (April 1-10, 2020). The survey comprised questions concerning socio-demographics, knowledge of COVID-19, behavior towards COVID-19, fear of COVID-19, insomnia, depression, and suicidal ideation. Logistic regression and structural equation modeling (SEM) analyses were performed to identify the risk factors depression and suicidal ideation. Geographical information system (GIS)-based spatial analysis was used to identify district-wise susceptibility to depression and suicidal ideation.\r\n\r\nThe prevalence rate of depression and suicidal ideation related to COVID-19 was 33% and 5%%. Common risk factors for suicidal ideation and depression included being young, being female, being a cigarette smoker, having comorbid diseases, having high scores on the Fear COVID-19 Scale, and having insomnia symptoms. GIS-based maps detected high depression and suicidal ideation in the capital of Bangladesh and the districts near the capital as well as coastal areas where COVID-19 prevalence was high, as compared with districts with no reported cases.\r\n\r\nSelf-reported scales and cross-sectional design of the study.\r\n\r\nCOVID-19 is associated with major psychological impact across Bangladesh, underlining the need of strategically located psychological support measures and improved access to mental health services, especially among women and younger people.", "doi": "10.1016/j.jad.2020.10.036", "pmid": "33120247", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0165-0327(20)32880-9"}, {"db": "pmc", "key": "PMC7568472"}], "notes": [], "created": "2020-12-01T15:09:02.752Z", "modified": "2022-11-09T08:48:33.526Z"}, {"entity": "publication", "iuid": "b550adb70b314df1a899f8f482650e72", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b550adb70b314df1a899f8f482650e72.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b550adb70b314df1a899f8f482650e72"}}, "title": "Rotational thromboelastometry results are associated with care level in COVID-19.", "authors": [{"family": "Almskog", "given": "Lou M", "initials": "LM"}, {"family": "Wikman", "given": "Agneta", "initials": "A"}, {"family": "Svensson", "given": "Jonas", "initials": "J"}, {"family": "Wanecek", "given": "Michael", "initials": "M"}, {"family": "Bottai", "given": "Matteo", "initials": "M"}, {"family": "van der Linden", "given": "Jan", "initials": "J"}, {"family": "\u00c5gren", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2020-10-17", "journal": {"title": "J Thromb Thrombolysis", "issn": "1573-742X", "volume": null, "issue": null, "issn-l": null}, "abstract": "High prevalence of thrombotic events in severely ill COVID-19 patients have been reported. Pulmonary embolism as well as microembolization of vital organs may in these individuals be direct causes of death. The identification of patients at high risk of developing thrombosis may lead to targeted, more effective prophylactic treatment. The primary aim of this study was to test whether rotational thromboelastometry (ROTEM) at admission indicates hypercoagulopathy and predicts the disease severity, assessed as care level, in COVID-19 patients. The study was designed as a prospective, observational study where COVID-19 patients over 18 years admitted to hospital were eligible for inclusion. Patients were divided into two groups depending on care level: (1) regular wards or (2) wards with specialized ventilation support. Conventional coagulation tests, blood type and ROTEM were taken at admission. 60 patients were included; age 61 (median), 67% men, many with comorbidities (e.g. hypertension, diabetes). The ROTEM variables Maximum Clot Firmness (EXTEM-/FIBTEM-MCF) were higher in COVID-19 patients compared with in healthy controls (p < 0.001) and higher in severely ill patients compared with in patients at regular wards (p < 0.05). Our results suggest that hypercoagulopathy is present early in patients with mild to moderate disease, and more pronounced in severe COVID-19 pneumonia. Non-O blood types were not overrepresented in COVID-19 positive patients. ROTEM variables showed hypercoagulopathy at admission and this pattern was more pronounced in patients with increased disease severity. If this feature is to be used to predict the risk of thromboembolic complications further studies are warranted.", "doi": "10.1007/s11239-020-02312-3", "pmid": "33068277", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.5878/wh80-0w17", "description": "Raw data"}], "notes": [], "created": "2020-12-01T17:06:38.593Z", "modified": "2021-02-26T08:45:48.601Z"}, {"entity": "publication", "iuid": "bd8661a4c7074ab29dc024d662305526", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bd8661a4c7074ab29dc024d662305526.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bd8661a4c7074ab29dc024d662305526"}}, "title": "Harmonization of antineutrophil cytoplasmic antibodies (ANCA) testing by reporting test result-specific likelihood ratios: position paper.", "authors": [{"family": "Bossuyt", "given": "Xavier", "initials": "X"}, {"family": "Damoiseaux", "given": "Jan", "initials": "J"}, {"family": "Rasmussen", "given": "Niels", "initials": "N"}, {"family": "van Paassen", "given": "Pieter", "initials": "P"}, {"family": "Hellmich", "given": "Bernard", "initials": "B"}, {"family": "Baslund", "given": "Bo", "initials": "B"}, {"family": "Blockmans", "given": "Daniel", "initials": "D"}, {"family": "Vermeersch", "given": "Pieter", "initials": "P"}, {"family": "Lopez-Hoyos", "given": "Marcos", "initials": "M"}, {"family": "Vercammen", "given": "Martine", "initials": "M"}, {"family": "Barret", "given": "Elisa", "initials": "E"}, {"family": "Hammar", "given": "Friederike", "initials": "F"}, {"family": "Leinfelder", "given": "Ulrich", "initials": "U"}, {"family": "Mahler", "given": "Michael", "initials": "M"}, {"family": "Olschowka", "given": "Nina", "initials": "N"}, {"family": "Roggenbuck", "given": "Dirk", "initials": "D"}, {"family": "Schlumberger", "given": "Wolfgang", "initials": "W"}, {"family": "Walker", "given": "Roger", "initials": "R"}, {"family": "R\u00f6nnelid", "given": "Johan", "initials": "J"}, {"family": "Cohen Tervaert", "given": "Jan-Willem", "initials": "JW"}, {"family": "Csernok", "given": "Elena", "initials": "E"}, {"family": "Fierz", "given": "Walter", "initials": "W"}, {"family": "for (i) the European Federation of Laboratory Medicine (EFLM) Task and Finish Group \u201cAutoimmunity Testing,\u201d (ii) the European Autoimmune Standardization Initiative (EASI) and the (iii) European Consensus Finding Study Group on autoantibodies (ECFSG)", "given": "", "initials": ""}], "type": "letter", "published": "2020-10-16", "journal": {"title": "Clin Chem Lab Med", "issn": "1437-4331", "volume": null, "issue": null, "issn-l": "1434-6621"}, "abstract": null, "doi": "10.1515/cclm-2020-1178", "pmid": "33027040", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "/j/cclm.ahead-of-print/cclm-2020-1178/cclm-2020-1178.xml"}], "notes": [], "created": "2020-11-19T19:46:53.265Z", "modified": "2021-02-26T08:46:13.472Z"}, {"entity": "publication", "iuid": "6bae92ff5cf94413903de7a063df791d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6bae92ff5cf94413903de7a063df791d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6bae92ff5cf94413903de7a063df791d"}}, "title": "Asthma and severe acute respiratory syndrome coronavirus 2019: current evidence and knowledge gaps.", "authors": [{"family": "Assaf", "given": "Sara M", "initials": "SM"}, {"family": "Tarasevych", "given": "Svitlana P", "initials": "SP"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}, {"family": "Hanania", "given": "Nicola A", "initials": "NA"}], "type": "journal article", "published": "2020-10-16", "journal": {"title": "Curr Opin Pulm Med", "issn": "1531-6971", "volume": null, "issue": null, "issn-l": "1070-5287"}, "abstract": "Although respiratory viruses are common triggers of asthma exacerbation, it is unknown whether this also applies to infection with SARS-CoV-2. Indeed, patients with asthma and allergy appear underrepresented in large reports of COVID-19 cases worldwide. In this review, we evaluate existing literature on this topic and potential underlying mechanisms for any interrelationship between asthma and COVID-19.\n\nData from several preclinical and clinical reports suggest a lower susceptibility for COVID-19 in patients with underlying type 2 airway inflammation including asthma that may be related to a reduced expression of ACE2 and TMPRSS2 receptors for SARS-CoV-2. Corticosteroids further decrease expression of the ACE2 and TMPRSS2 receptors, hence may also have a protective effect against infection with SARS-CoV-2. In addition, some studies suggest that the reported improvement in asthma control and a reduction in asthma exacerbations during the COVID-19 pandemic may be related to improvement in adherence to controller therapy and reduced exposure to triggers, such as other respiratory viruses and air pollutants. Recent data point towards differential susceptibility for COVID-19 among asthma patients based on their phenotype and/or endotype. On the basis of existing evidence, continuation with controller therapies is recommended for all patients with asthma. For patients with severe uncontrolled asthma infected by SARS-CoV-2, adjustment of controllers and biologics should be based on a multidisciplinary decision.\n\nUnderrepresentation of SARS-CoV-2-infected patients with asthma and related allergic diseases may be based on potentially protective underlying mechanisms, such as type 2 airway inflammation, downregulation of ACE2/TMPRSS2 receptors, reduced exposures to triggers and improved adherence to controller medications. Although it is imperative that control should be maintained and asthma medications be continued in all patients, management of patients with severe uncontrolled asthma infected by SARS-CoV-2 including adjustment of controllers and biologics should be discussed on an individual basis.", "doi": "10.1097/MCP.0000000000000744", "pmid": "33065601", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-27T11:51:37.680Z", "modified": "2020-11-27T12:38:55.348Z"}, {"entity": "publication", "iuid": "6854c632851b4cf8a636d73aa8c35e0f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6854c632851b4cf8a636d73aa8c35e0f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6854c632851b4cf8a636d73aa8c35e0f"}}, "title": "The Impact of the German Strategy for Containment of Coronavirus SARS-CoV-2 on Training Characteristics, Physical Activity and Sleep of Highly Trained Kayakers and Canoeists: A Retrospective Observational Study.", "authors": [{"family": "Zinner", "given": "Christoph", "initials": "C"}, {"family": "Matzka", "given": "Manuel", "initials": "M"}, {"family": "Leppich", "given": "Robert", "initials": "R"}, {"family": "Kounev", "given": "Samuel", "initials": "S"}, {"family": "Holmberg", "given": "Hans-Christer", "initials": "HC"}, {"family": "Sperlich", "given": "Billy", "initials": "B"}], "type": "journal article", "published": "2020-10-15", "journal": {"title": "Front Sports Act Living", "issn": "2624-9367", "volume": "2", "issue": null, "pages": "579830", "issn-l": null}, "abstract": "Aim: To characterize the impact of the German strategy for containment of Coronavirus SARS-CoV-2 (social distancing and lockdown) on the training, other habitual physical activity, and sleep in highly trained kayakers and canoeists. Method: During the 4 weeks immediately prior to and following the beginning of the German government's strategy for containment of Coronavirus SARS-CoV-2 on March 23, 2020, 14 highly trained athletes (VO2peak: 3,162 \u00b1 774 ml/min; 500-m best time: 117.9 \u00b1 7.9 s) wore a multi-sensor smartwatch to allow continuous assessment of heart rate, physical activity, and sleep duration. Result: In comparison to before lockdown, the overall weekly training time and the average length of each session of training during the lockdown decreased by 27.6% (P = 0.02; d = 0.91) and 15.4% (P = 0.36; d = 0.36), respectively. At the same time, the number of sessions involving specific (i.e., canoeing and kayaking) and non-specific (i.e., running, cycling) training, respectively, did not change (P = 0.36-0.37; d = 0.34-0.35). The number of sessions involving strength (+17.4%; P = 0.03; d = 0.89) or other types of training (+16.7%; P = 0.06; d = 0.75) increased during the lockdown with 2.8-17.5% more training time involving a heart rate <60%, 82-88, 89-93, or 94-100% of individual peak heart rate (HRpeak) (P = 0.03-0.86; d = 0.07-1.38), and 4.3-18.7% less time with a heart rate of 60-72 or 73-83% HRpeak (P = < 0.001-0.0.26; d = 0.44-2.24). The daily duration of sleep was ~30 min (6.7%) longer during the lockdown (P < 0.001; d = 1.53) and the overall time spent lying down was 17% greater (P < 0.001; d = 2.26); whereas sitting time (-9.4%; P = 0.003; d = 1.23), the duration of light (15 min; -7.3%; P = 0.04; d = 0.83), and moderate (-18.6%; P = 0.01; d = 1.00) physical activity other than training (-9.4%; P = 0.22; d = 0.00) were all lower during lockdown. Conclusion: The present data revealed that following the German lockdown for containment of the Coronavirus SARS-CoV-2, highly trained kayakers and canoeists spent less overall time training each week (-27.6%) with, on average, shorter training sessions (-15.1%) and less light-to-moderate physical activity outside of training. Moreover, they performed more strength training sessions per week, and all engaged in more training at intensities >82 and <60% of HRpeak and spent longer periods lying down and sleeping during the lockdown.", "doi": "10.3389/fspor.2020.579830", "pmid": "33345147", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7739795"}], "notes": [], "created": "2021-01-07T13:29:20.028Z", "modified": "2023-06-19T14:55:02.352Z"}, {"entity": "publication", "iuid": "adafb3508b7648b9860b5e515ac65d25", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/adafb3508b7648b9860b5e515ac65d25.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/adafb3508b7648b9860b5e515ac65d25"}}, "title": "Satellite-detected tropospheric nitrogen dioxide and spread of SARS-CoV-2 infection in Northern Italy.", "authors": [{"family": "Filippini", "given": "Tommaso", "initials": "T"}, {"family": "Rothman", "given": "Kenneth J", "initials": "KJ"}, {"family": "Goffi", "given": "Alessia", "initials": "A"}, {"family": "Ferrari", "given": "Fabrizio", "initials": "F"}, {"family": "Maffeis", "given": "Giuseppe", "initials": "G"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}, {"family": "Vinceti", "given": "Marco", "initials": "M"}], "type": "journal article", "published": "2020-10-15", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "volume": "739", "issue": null, "pages": "140278", "issn-l": "0048-9697"}, "abstract": "Following the outbreak of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) last December 2019 in China, Italy was the first European country to be severely affected, with the first local case diagnosed on 20 February 2020. The virus spread quickly, particularly in the North of Italy, with three regions (Lombardy, Veneto and Emilia-Romagna) being the most severely affected. These three regions accounted for >80% of SARS-CoV-2 positive cases when the tight lockdown was established (March 8). These regions include one of Europe's areas of heaviest air pollution, the Po valley. Air pollution has been recently proposed as a possible risk factor of SARS-CoV-2 infection, due to its adverse effect on immunity and to the possibility that polluted air may even carry the virus. We investigated the association between air pollution and subsequent spread of the SARS-CoV-2 infection within these regions. We collected NO 2 tropospheric levels using satellite data available at the European Space Agency before the lockdown. Using a multivariable restricted cubic spline regression model, we compared NO2 levels with SARS-CoV-2 infection prevalence rate at different time points after the lockdown, namely March 8, 22 and April 5, in the 28 provinces of Lombardy, Veneto and Emilia-Romagna. We found little association of NO2 levels with SARS-CoV-2 prevalence up to about 130 \u03bcmol/m2, while a positive association was evident at higher levels at each time point. Notwithstanding the limitations of the use of aggregated data, these findings lend some support to the hypothesis that high levels of air pollution may favor the spread of the SARS-CoV-2 infection.", "doi": "10.1016/j.scitotenv.2020.140278", "pmid": "32758963", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(20)33799-2"}, {"db": "pmc", "key": "PMC7297152"}], "notes": [], "created": "2020-12-07T15:43:31.840Z", "modified": "2020-12-07T15:43:31.851Z"}, {"entity": "publication", "iuid": "71feecb0597d4021a3035ca71bab259e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/71feecb0597d4021a3035ca71bab259e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/71feecb0597d4021a3035ca71bab259e"}}, "title": "SARS-CoV-2 (COVID-19) infection in pregnant women: characterization of symptoms and syndromes predictive of disease and severity through real-time, remote participatory epidemiology.", "authors": [{"family": "Molteni", "given": "Erika", "initials": "E", "orcid": "0000-0001-7773-8140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9aed1fbe444b48d4bfacb12050953c8e.json"}}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Sudre", "given": "Carole H", "initials": "CH", "orcid": "0000-0001-5753-428X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c26472813fed4007a8757af771de1802.json"}}, {"family": "Magee", "given": "Laura A", "initials": "LA", "orcid": "0000-0002-1355-610X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ee8a639fe1c489887b631cec86a872d.json"}}, {"family": "Murray", "given": "Benjamin", "initials": "B"}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f34c0d3602439abe6096293c7c732d.json"}}, {"family": "Gomez", "given": "Maria F", "initials": "MF", "orcid": "0000-0001-6210-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e09e37219c4f42c8a7b3a982da523859.json"}}, {"family": "Tsereteli", "given": "Neli", "initials": "N"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Brownstein", "given": "John S", "initials": "JS", "orcid": "0000-0001-8568-5317", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2be459b61ae457e8fdcef38a0bc4cf7.json"}}, {"family": "Davies", "given": "Richard", "initials": "R"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Ourselin", "given": "Sebastien", "initials": "S", "orcid": "0000-0002-5694-5340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74c7b9b1633144879042d198c7205656.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "Modat", "given": "Marc", "initials": "M", "orcid": "0000-0002-5277-8530", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/794a8484b16a4a42a35c505688018eb1.json"}}], "type": "preprint", "published": "2020-10-14", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To test whether pregnant and non-pregnant women differ in COVID-19 symptom profile and severity. To extend previous investigations on hospitalized pregnant women to those who did not require hospitalization.\n\nObservational study prospectively collecting longitudinal (smartphone application interface) and cross-sectional (web-based survey) data.\n\nCommunity-based self-participatory citizen surveillance in the United Kingdom, Sweden and the United States of America.\n\nTwo female community-based cohorts aged 18-44 years. The discovery cohort was drawn from 1,170,315 UK, Sweden and USA women (79 pregnant tested positive) who self-reported status and symptoms longitudinally via smartphone. The replication cohort included 1,344,966 USA women (134 pregnant tested positive) who provided cross-sectional self-reports.\n\nPregnant and non-pregnant were compared for frequencies of symptoms and events, including SARS-CoV-2 testing and hospitalization rates. Multivariable regression was used to investigate symptoms severity and comorbidity effects.\n\nPregnant and non-pregnant women positive for SARS-CoV-2 infection were not different in syndromic severity. Pregnant were more likely to have received testing than non-pregnant, despite reporting fewer symptoms. Pre-existing lung disease was most closely associated with the syndromic severity in pregnant hospitalized women. Heart and kidney diseases and diabetes increased risk. The most frequent symptoms among all non-hospitalized women were anosmia [63% pregnant, 92% non-pregnant] and headache [72%, 62%]. Cardiopulmonary symptoms, including persistent cough [80%] and chest pain [73%], were more frequent among pregnant women who were hospitalized.\n\nSymptom characteristics and severity were comparable among pregnant and non-pregnant women, except for gastrointestinal symptoms. Consistent with observations in non-pregnant populations, lung disease and diabetes were associated with increased risk of more severe SARS-CoV-2 infection during pregnancy.", "doi": "10.1101/2020.08.17.20161760", "pmid": "32839787", "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7444306"}, {"db": "pii", "key": "2020.08.17.20161760"}], "notes": [], "created": "2020-12-07T10:29:38.783Z", "modified": "2023-06-19T15:08:12.850Z"}, {"entity": "publication", "iuid": "921293bc4dd94ced8c6db449251f6eae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/921293bc4dd94ced8c6db449251f6eae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/921293bc4dd94ced8c6db449251f6eae"}}, "title": "Rethinking developed nations' health systems through a social sustainability perspective in the light of the COVID-19 pandemic. A viewpoint.", "authors": [{"family": "Macassa", "given": "Gloria", "initials": "G"}, {"family": "Tomaselli", "given": "Gianpaolo", "initials": "G"}], "type": "journal article", "published": "2020-10-14", "journal": {"title": "J Public Health Res", "issn": "2279-9028", "volume": "9", "issue": "4", "pages": "1834", "issn-l": null}, "abstract": "This viewpoint paper argues for the need for more socially sustainable care systems that can better contribute to equitable utilization of health care in a post-pandemic era. Health care systems in developed nations need to rethink their role, particularly with regard to the achievement of Sustainable Development Goal 3 (SDG 3) as well as becoming more sustainable societies. Socially sustainable care systems will recognize that systemic factors and processes (social, economic, environmental, cultural) need to be addressed simultaneously in order to achieve health equity. Moreover, these systems are likely to be of paramount importance for post-COVID-19, because of the potential increase in demand for health care due to forgone health care and the increased burden of chronic diseases as spillover effects related to COVID-19 mitigation interventions.", "doi": "10.4081/jphr.2020.1834", "pmid": "33209860", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7649672"}], "notes": [], "created": "2020-11-30T16:11:49.861Z", "modified": "2020-11-30T16:11:49.885Z"}, {"entity": "publication", "iuid": "e8e888fa0a634256b20d6587ef48b94c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e8e888fa0a634256b20d6587ef48b94c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e8e888fa0a634256b20d6587ef48b94c"}}, "title": "Global impact of COVID-19 on non-communicable disease management: descriptive analysis of access to FRAX fracture risk online tool for prevention of osteoporotic fractures.", "authors": [{"family": "McCloskey", "given": "E V", "initials": "EV"}, {"family": "Harvey", "given": "N C", "initials": "NC"}, {"family": "Johansson", "given": "H", "initials": "H"}, {"family": "Lorentzon", "given": "M", "initials": "M"}, {"family": "Vandenput", "given": "L", "initials": "L"}, {"family": "Liu", "given": "E", "initials": "E"}, {"family": "Kanis", "given": "J A", "initials": "JA"}], "type": "journal article", "published": "2020-10-14", "journal": {"title": "Osteoporos Int", "issn": "1433-2965", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic, and its management, is markedly impacting the management of osteoporosis as judged by access to online FRAX fracture risk assessments. Globally, access was 58% lower in April than in February 2020. Strategies to improve osteoporosis care, with greater use of fracture risk assessments, offer a partial solution.\r\n\r\nThe COVID-19 pandemic is having a significant detrimental impact on the management of chronic diseases including osteoporosis. We have quantified the global impact by examining changes in the usage of online FRAX fracture risk assessments before and after the declaration of the pandemic (11 March 2020).\r\n\r\nThe study comprised a retrospective analysis using GoogleAnalytics data on daily sessions on the FRAX\u00ae website ( www.sheffield.ac.uk/FRAX ) from November 2019 to April 2020 (main analysis period February-April 2020), and the geographical source of that activity.\r\n\r\nOver February-April 2020, the FRAX website recorded 460,495 sessions from 184 countries, with 210,656 sessions in February alone. In March and April, the number of sessions fell by 23.1% and 58.3% respectively, a pattern not observed over the same period in 2019. There were smaller reductions in Asia than elsewhere, partly related to earlier and less-marked nadirs in some countries (China, Taiwan, Hong Kong, South Korea and Vietnam). In Europe, the majority of countries (24/31, 77.4%) reduced usage by at least 50% in April. Seven countries showed smaller reductions (range - 2.85 to - 44.1%) including Poland, Slovakia, Czech Republic, Germany, Norway, Sweden and Finland. There was no significant relationship between the reduction in FRAX usage and measures of disease burden such as COVID-attributed deaths per million of the population.\r\n\r\nThis study documents a marked global impact of the COVID-19 pandemic on the management of osteoporosis as reflected by FRAX online fracture risk assessments. The analysis suggests that impact may relate to the societal and healthcare measures taken to ameliorate the pandemic.", "doi": "10.1007/s00198-020-05542-6", "pmid": "33057738", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00198-020-05542-6"}, {"db": "pmc", "key": "PMC7556595"}], "notes": [], "created": "2020-12-01T17:11:07.268Z", "modified": "2022-11-09T08:54:18.900Z"}, {"entity": "publication", "iuid": "56017c8d0b4a4351a6f0654886292ba0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56017c8d0b4a4351a6f0654886292ba0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56017c8d0b4a4351a6f0654886292ba0"}}, "title": "Benchmarking virus concentration methods for quantification of SARS-CoV-2 in raw wastewater", "authors": [{"family": "Jafferali", "given": "Mohammed Hakim", "initials": "MH"}, {"family": "Khatami", "given": "Kasra", "initials": "K"}, {"family": "Atasoy", "given": "Merve", "initials": "M"}, {"family": "Birgersson", "given": "Madeleine", "initials": "M"}, {"family": "Williams", "given": "Cecilia", "initials": "C"}, {"family": "Cetecioglu", "given": "Zeynep", "initials": "Z"}], "type": "journal-article", "published": "2020-10-14", "journal": {"title": "Science of The Total Environment", "issn": "0048-9697", "issn-l": "0048-9697", "volume": "755", "issue": "Pt 1", "pages": "142939"}, "abstract": "Wastewater-based epidemiology offers a cost-effective alternative to testing large populations for SARS-CoV-2 virus, and may potentially be used as an early warning system for SARS-CoV-2 pandemic spread. However, viruses are highly diluted in wastewater, and a validated method for their concentration and further processing, and suitable reference viruses, are the main needs to be established for reliable SARS-CoV-2 municipal wastewater detection. For this purpose, we collected wastewater from two European cities during the Covid-19 pandemic and evaluated the sensitivity of RT-qPCR detection of viral RNA after four concentration methods (two variants of ultrafiltration-based method and two adsorption and extraction-based methods). Further, we evaluated one external (bovine corona virus) and one internal (pepper mild mottle virus) reference virus. We found a consistently higher recovery of spiked virus using the modified ultrafiltration-based method. This method also had a significantly higher efficiency (p-value <0.01) for wastewater SARS-CoV-2 detection. The ultracentrifugation method was the only method that detected SARS-CoV-2 in the wastewater of both cities. The pepper mild mottle virus was found to function as a potentially suitable internal reference standard.", "doi": "10.1016/j.scitotenv.2020.142939", "pmid": "33121776", "labels": {"Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Funder: VR": null, "Research Area: Environmental virus profiling": null}, "xrefs": [], "notes": [], "created": "2020-11-04T16:24:02.607Z", "modified": "2021-06-13T14:20:47.780Z"}, {"entity": "publication", "iuid": "11fc0facc2b6421f9c19355255e2c2a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/11fc0facc2b6421f9c19355255e2c2a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/11fc0facc2b6421f9c19355255e2c2a1"}}, "title": "A materials-science perspective on tackling COVID-19.", "authors": [{"family": "Tang", "given": "Zhongmin", "initials": "Z", "orcid": "0000-0002-1532-8004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c277e0db294d1dbf4cf183b78392cd.json"}}, {"family": "Kong", "given": "Na", "initials": "N"}, {"family": "Zhang", "given": "Xingcai", "initials": "X", "orcid": "0000-0001-7114-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c328b6119cf54f8589012b0add4f13ef.json"}}, {"family": "Liu", "given": "Yuan", "initials": "Y"}, {"family": "Hu", "given": "Ping", "initials": "P"}, {"family": "Mou", "given": "Shan", "initials": "S"}, {"family": "Liljestr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Shi", "given": "Jianlin", "initials": "J", "orcid": "0000-0001-8790-195X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9e484b2f7d5414585be457b42d13dba.json"}}, {"family": "Tan", "given": "Weihong", "initials": "W", "orcid": "0000-0002-8066-1524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc983c96b5874c20adf7a7e8c5e511be.json"}}, {"family": "Kim", "given": "Jong Seung", "initials": "JS"}, {"family": "Cao", "given": "Yihai", "initials": "Y"}, {"family": "Langer", "given": "Robert", "initials": "R", "orcid": "0000-0003-4255-0492", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ee4392159f340659f2e334c799dfd12.json"}}, {"family": "Leong", "given": "Kam W", "initials": "KW"}, {"family": "Farokhzad", "given": "Omid C", "initials": "OC"}, {"family": "Tao", "given": "Wei", "initials": "W", "orcid": "0000-0002-4277-3728", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5ed1e15ddf44fe4bfc6ad8d5cd35379.json"}}], "type": "journal article", "published": "2020-10-14", "journal": {"title": "Nat Rev Mater", "issn": "2058-8437", "volume": "5", "issue": "11", "pages": "847-860", "issn-l": "2058-8437"}, "abstract": "The ongoing SARS-CoV-2 pandemic highlights the importance of materials science in providing tools and technologies for antiviral research and treatment development. In this Review, we discuss previous efforts in materials science in developing imaging systems and microfluidic devices for the in-depth and real-time investigation of viral structures and transmission, as well as material platforms for the detection of viruses and the delivery of antiviral drugs and vaccines. We highlight the contribution of materials science to the manufacturing of personal protective equipment and to the design of simple, accurate and low-cost virus-detection devices. We then investigate future possibilities of materials science in antiviral research and treatment development, examining the role of materials in antiviral-drug design, including the importance of synthetic material platforms for organoids and organs-on-a-chip, in drug delivery and vaccination, and for the production of medical equipment. Materials-science-based technologies not only contribute to the ongoing SARS-CoV-2 research efforts but can also provide platforms and tools for the understanding, protection, detection and treatment of future viral diseases.", "doi": "10.1038/s41578-020-00247-y", "pmid": "33078077", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7556605"}, {"db": "pii", "key": "247"}], "notes": [], "created": "2020-11-26T12:20:01.618Z", "modified": "2023-06-19T14:36:07.995Z"}, {"entity": "publication", "iuid": "782ddc32ba1b4bafaf233aaa77d0e0d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/782ddc32ba1b4bafaf233aaa77d0e0d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/782ddc32ba1b4bafaf233aaa77d0e0d5"}}, "title": "The COVID-19 pandemic: The importance of physical activity among faculty members.", "authors": [{"family": "Fr\u00f6berg", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2020-10-13", "journal": {"title": "J Am Coll Health", "issn": "1940-3208", "issn-l": null, "volume": null, "issue": null, "pages": "1-4"}, "abstract": "The novel coronavirus (SARS-CoV-2) disease 2019 (COVID-19) pandemic has posed serious challenge to societies worldwide. To prevent person-to-person transmission of the coronavirus and avoid associated morbidity and mortality, several public health measures have been introduced by various health organizations and authorities, such as social distancing policies and quarantine. While necessary, these public health measures are likely to have implications for people's physical activity behaviors. This viewpoint is intended for faculty members and focus on the importance of physical activity for health. Suggestions on how to stay physically active during the COVID-19 pandemic are also provided.", "doi": "10.1080/07448481.2020.1817037", "pmid": "33048633", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-01T17:12:20.056Z", "modified": "2022-11-09T08:55:35.729Z"}, {"entity": "publication", "iuid": "a99bb5289fde46d39c4ab2f27181521a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a99bb5289fde46d39c4ab2f27181521a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a99bb5289fde46d39c4ab2f27181521a"}}, "title": "Registry reports in COVID-19 patients: Juggling with big data, poor data, and no data.", "authors": [{"family": "S\u00f8fteland", "given": "John Mackay", "initials": "JM"}, {"family": "Karason", "given": "Kristjan", "initials": "K"}, {"family": "Magnusson", "given": "Jesper", "initials": "J"}, {"family": "Schult", "given": "Andreas", "initials": "A"}, {"family": "Felldin", "given": "Marie", "initials": "M"}, {"family": "Friman", "given": "Vanda", "initials": "V"}, {"family": "Oltean", "given": "Mihai", "initials": "M"}], "type": "letter", "published": "2020-10-13", "journal": {"title": "Kidney Int", "issn": "1523-1755", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.kint.2020.09.017", "pmid": "33065132", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0085-2538(20)31181-9"}, {"db": "pmc", "key": "PMC7550855"}], "notes": [], "created": "2020-12-01T17:08:55.634Z", "modified": "2020-12-01T17:08:55.656Z"}, {"entity": "publication", "iuid": "a49fb892a93344f393c58081203719f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a49fb892a93344f393c58081203719f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a49fb892a93344f393c58081203719f7"}}, "title": "Mass gathering events and undetected transmission of SARS-CoV-2 in vulnerable populations leading to an outbreak with high case fatality ratio in the district of Tirschenreuth, Germany.", "authors": [{"family": "Brandl", "given": "M", "initials": "M"}, {"family": "Selb", "given": "R", "initials": "R"}, {"family": "Seidl-Pillmeier", "given": "S", "initials": "S"}, {"family": "Marosevic", "given": "D", "initials": "D"}, {"family": "Buchholz", "given": "U", "initials": "U"}, {"family": "Rehmet", "given": "S", "initials": "S"}], "type": "journal article", "published": "2020-10-13", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": "148", "issue": null, "pages": "e252", "issn-l": null}, "abstract": "In early March 2020, a COVID-19-outbreak occurred in the district of Tirschenreuth, Germany. The outbreak was characterised by a rapid increase in case numbers and a comparatively high crude case fatality ratio (CFR; 11%). Until the beginning of May 2020, 1122 cases were reported in the district. To investigate the outbreak, we analysed surveillance and other data available at the district health department, including data on cases living in care facilities and public health measures applied. Furthermore, we compared the number of tests performed in Tirschenreuth and in Germany as a whole. We interviewed the first 110 cases in order to investigate potential exposures at the beginning of the outbreak. We found that returning ski-travellers from Austria and Italy and early undetected community transmission likely initiated the outbreak which was then accelerated by Bavarian beer festivities. Testing of mainly acute cases in the district of Tirschenreuth resulted in a higher rate of positive tests compared to the whole of Germany. Despite adjustment for age, the CFR continued to exceed the German mean which was due to spread to vulnerable populations. Strict public health measures likely contributed to control the outbreak by mid-April 2020.", "doi": "10.1017/S0950268820002460", "pmid": "33046173", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0950268820002460"}, {"db": "pmc", "key": "PMC7588716"}], "notes": [], "created": "2020-12-01T17:14:59.942Z", "modified": "2021-02-26T08:45:48.542Z"}, {"entity": "publication", "iuid": "c349b903a6a94f64b50936430c06a8d2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c349b903a6a94f64b50936430c06a8d2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c349b903a6a94f64b50936430c06a8d2"}}, "title": "Influenza Vaccination to Reduce Cardiovascular Morbidity and Mortality in Patients With COVID-19: JACC State-of-the-Art Review.", "authors": [{"family": "Behrouzi", "given": "Bahar", "initials": "B"}, {"family": "Araujo Campoverde", "given": "Maria Viviana", "initials": "MV"}, {"family": "Liang", "given": "Kyle", "initials": "K"}, {"family": "Talbot", "given": "H Keipp", "initials": "HK"}, {"family": "Bogoch", "given": "Isaac I", "initials": "II"}, {"family": "McGeer", "given": "Allison", "initials": "A"}, {"family": "Fr\u00f6bert", "given": "Ole", "initials": "O"}, {"family": "Loeb", "given": "Mark", "initials": "M"}, {"family": "Vardeny", "given": "Orly", "initials": "O"}, {"family": "Solomon", "given": "Scott D", "initials": "SD"}, {"family": "Udell", "given": "Jacob A", "initials": "JA"}], "type": "journal article", "published": "2020-10-13", "journal": {"title": "J Am Coll Cardiol", "issn": "1558-3597", "volume": "76", "issue": "15", "pages": "1777-1794", "issn-l": "0735-1097"}, "abstract": "Viral respiratory infections are risk factors for cardiovascular disease (CVD). Underlying CVD is also associated with an increased risk of complications following viral respiratory infections, including increased morbidity, mortality, and health care utilization. Globally, these phenomena are observed with seasonal influenza and with the current coronavirus disease 2019 (COVID-19) pandemic. Persons with CVD represent an important target population for respiratory virus vaccines, with capacity developed within 3 large ongoing influenza vaccine cardiovascular outcomes trials to determine the potential cardioprotective effects of influenza vaccines. In the context of COVID-19, these international trial networks may be uniquely positioned to redeploy infrastructure to study therapies for primary and secondary prevention of COVID-19. Here, we describe mechanistic links between influenza and COVID-19 infection and the risk of acute cardiovascular events, summarize the data to date on the potential cardioprotective effects of influenza vaccines, and describe the ongoing influenza vaccine cardiovascular outcomes trials, highlighting important lessons learned that are applicable to COVID-19.", "doi": "10.1016/j.jacc.2020.08.028", "pmid": "33032740", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0735-1097(20)36325-7"}, {"db": "pmc", "key": "PMC7535809"}], "notes": [], "created": "2020-11-27T12:38:57.742Z", "modified": "2020-11-27T12:38:57.764Z"}, {"entity": "publication", "iuid": "f71ffb963b69438bbc97e6ec3b99934a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f71ffb963b69438bbc97e6ec3b99934a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f71ffb963b69438bbc97e6ec3b99934a"}}, "title": "The Impact of the COVID-19 Pandemic on Surgical Management of Breast Cancer: Global Trends and Future Perspectives.", "authors": [{"family": "Rocco", "given": "Nicola", "initials": "N"}, {"family": "Montagna", "given": "Giacomo", "initials": "G"}, {"family": "Di Micco", "given": "Rosa", "initials": "R"}, {"family": "Benson", "given": "John", "initials": "J"}, {"family": "Criscitiello", "given": "Carmen", "initials": "C"}, {"family": "Chen", "given": "Li", "initials": "L"}, {"family": "Di Pace", "given": "Bruno", "initials": "B"}, {"family": "Esgueva Colmenarejo", "given": "Antonio Jesus", "initials": "AJ"}, {"family": "Harder", "given": "Yves", "initials": "Y"}, {"family": "Karakatsanis", "given": "Andreas", "initials": "A"}, {"family": "Maglia", "given": "Anna", "initials": "A"}, {"family": "Mele", "given": "Marco", "initials": "M"}, {"family": "Nafissi", "given": "Nahid", "initials": "N"}, {"family": "Ferreira", "given": "Pedro Santos", "initials": "PS"}, {"family": "Taher", "given": "Wafa", "initials": "W"}, {"family": "Tejerina", "given": "Antonio", "initials": "A"}, {"family": "Vinci", "given": "Alessio", "initials": "A"}, {"family": "Nava", "given": "Maurizio", "initials": "M"}, {"family": "Catanuto", "given": "Giuseppe", "initials": "G"}], "type": "journal article", "published": "2020-10-12", "journal": {"title": "Oncologist", "issn": "1549-490X", "volume": "26", "issue": "1", "pages": "e66-e77", "issn-l": null}, "abstract": "The rapid spread of COVID-19 across the globe is forcing surgical oncologists to change their daily practice. We sought to evaluate how breast surgeons are adapting their surgical activity to limit viral spread and spare hospital resources.\n\nA panel of 12 breast surgeons from the most affected regions of the world convened a virtual meeting on April 7, 2020, to discuss the changes in their local surgical practice during the COVID-19 pandemic. Similarly, a Web-based poll based was created to evaluate changes in surgical practice among breast surgeons from several countries.\n\nThe virtual meeting showed that distinct countries and regions were experiencing different phases of the pandemic. Surgical priority was given to patients with aggressive disease not candidate for primary systemic therapy, those with progressive disease under neoadjuvant systemic therapy, and patients who have finished neoadjuvant therapy. One hundred breast surgeons filled out the poll. The trend showed reductions in operating room schedules, indications for surgery, and consultations, with an increasingly restrictive approach to elective surgery with worsening of the pandemic.\n\nThe COVID-19 emergency should not compromise treatment of a potentially lethal disease such as breast cancer. Our results reveal that physicians are instinctively reluctant to abandon conventional standards of care when possible. However, as the situation deteriorates, alternative strategies of de-escalation are being adopted.\n\nThis study aimed to characterize how the COVID-19 pandemic is affecting breast cancer surgery and which strategies are being adopted to cope with the situation.", "doi": "10.1002/onco.13560", "pmid": "33044007", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7675306"}], "notes": [], "created": "2020-12-01T17:18:02.032Z", "modified": "2021-02-26T08:45:48.873Z"}, {"entity": "publication", "iuid": "3ea73e2997424ea4a5071572466b1f6f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ea73e2997424ea4a5071572466b1f6f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ea73e2997424ea4a5071572466b1f6f"}}, "title": "Cardiac Troponin Testing in Patients with COVID-19: A Strategy for Testing and Reporting Results.", "authors": [{"family": "Kavsak", "given": "Peter A", "initials": "PA"}, {"family": "Hammarsten", "given": "Ola", "initials": "O"}, {"family": "Worster", "given": "Andrew", "initials": "A"}, {"family": "Smith", "given": "Stephen W", "initials": "SW"}, {"family": "Apple", "given": "Fred S", "initials": "FS"}], "type": "journal article", "published": "2020-10-12", "journal": {"title": "Clin Chem", "issn": "1530-8561", "volume": "67", "issue": "1", "pages": "107-113", "issn-l": "0009-9147"}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged late in 2019 causing COVID-19 (coronavirus disease-2019) may adversely affect the cardiovascular system. Publications from Asia, Europe and North America have identified cardiac troponin as an important prognostic indicator for patients hospitalized with COVID-19. We recognized from publications within the first 6 months of the pandemic that there has been much uncertainty on the reporting, interpretation, and pathophysiology of an increased cardiac troponin concentration in this setting.\n\nThe purpose of this mini-review is: a) to review the pathophysiology of SARS-CoV-2 and the cardiovascular system, b) to overview the strengths and weaknesses of selected studies evaluating cardiac troponin in patients with COVID-19, and c) recommend testing strategies in the acute period, in the convalescence period and in long-term care for patients who have become ill with COVID-19.\n\nThis review provides important educational information and identifies gaps in understanding the role of cardiac troponin and COVID-19. Future, properly designed studies will hopefully provide the much-needed evidence on the path forward in testing cardiac troponin in patients with COVID-19.", "doi": "10.1093/clinchem/hvaa225", "pmid": "33045044", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "5921202"}, {"db": "pmc", "key": "PMC7665403"}], "notes": [], "created": "2020-11-27T12:38:56.488Z", "modified": "2021-01-22T09:27:06.802Z"}, {"entity": "publication", "iuid": "80775a0ee6f946ec9ea6ffe6c38eda01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/80775a0ee6f946ec9ea6ffe6c38eda01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/80775a0ee6f946ec9ea6ffe6c38eda01"}}, "title": "Minor covid-19 association with crime in Sweden.", "authors": [{"family": "Gerell", "given": "Manne", "initials": "M"}, {"family": "Kardell", "given": "Johan", "initials": "J"}, {"family": "Kindgren", "given": "Johanna", "initials": "J"}], "type": "journal article", "published": "2020-10-11", "journal": {"title": "Crime Sci", "issn": "2193-7680", "issn-l": null, "volume": "9", "issue": "1", "pages": "19"}, "abstract": "The covid-19 disease has a large impact on life across the globe, and this could potentially include impacts on crime. The present study describes how crime has changed in Sweden during ten weeks after the government started to implement interventions to reduce spread of the disease. Sweden has undertaken smaller interventions than many other countries and is therefore a particularly interesting case to study. The first major interventions in Sweden were implemented in the end of week 11 (March 12th) in the year 2020, and we analyze police reported crimes through week 21 (ending May 24th). Descriptive statistics are provided relative to expected levels with 95% confidence intervals for eight crime types. We find that total crime, assaults, pickpocketing and burglary have decreased significantly, personal robberies and narcotics crime are unchanged. Vandalism possibly increased somewhat but is hard to draw any firm conclusions on. The reductions are fairly small for most crime types, in the 5-20% range, with pickpocketing being the biggest exception noting a 59% drop relative to expected levels.", "doi": "10.1186/s40163-020-00128-3", "pmid": "33072489", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "128"}, {"db": "pmc", "key": "PMC7548025"}], "notes": [], "created": "2020-12-01T17:03:37.772Z", "modified": "2022-11-09T08:56:13.634Z"}, {"entity": "publication", "iuid": "82fea9198e95441299581781787cd5e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82fea9198e95441299581781787cd5e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82fea9198e95441299581781787cd5e8"}}, "title": "May Mangafodipir or Other SOD Mimetics Contribute to Better Care in COVID-19 Patients?", "authors": [{"family": "Karlsson", "given": "Jan Olof G", "initials": "JOG"}, {"family": "Jynge", "given": "Per", "initials": "P"}, {"family": "Ignarro", "given": "Louis J", "initials": "LJ"}], "type": "journal article", "published": "2020-10-10", "journal": {"title": "Antioxidants (Basel)", "issn": "2076-3921", "issn-l": "2076-3921", "volume": "9", "issue": "10", "pages": null}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by massive inflammation of the arterial endothelium accompanied by vasoconstriction and widespread pulmonary micro thrombi. As a result, due to the destruction of nitric oxide ( \u2022NO) by inflammatory superoxide (O2\u2022-), pulmonary \u2022NO concentration ceases, resulting in uncontrolled platelet aggregation and massive thrombosis, which kills the patients. Introducing \u2022NO by inhalation (INO) may replace the loss of endothelium-derived \u2022NO. The first results from clinical trials with INO in SARS-CoV-2 patients show a rapid and sustained improvement in cardiopulmonary function and decreased inflammation. An ongoing phase III study is expected to confirm the method's efficacy. INO may hence become a first line treatment in SARS-CoV-2 patients. However, due to the rapid inactivation of \u2022NO by deoxyhemoglobin to nitrate, pulmonary administration of \u2022NO will not protect remote organs. Another INO-related pharmacological approach to protect SARS-CoV-2 patients from developing life-threatening disease is to inhibit the O2\u2022--driven destruction of \u2022NO by neutralizing inflammatory O2\u2022-. By making use of low molecular weight compounds that mimic the action of the enzyme manganese superoxide dismutase (MnSOD). The MnSOD mimetics of the so-called porphyrin type (e.g., AEOL 10150), salen type (e.g., EUK-8) and cyclic polyamine type (e.g., M40419, today known as GC4419 and avasopasem manganese) have all been shown to positively affect the inflammatory response in lung epithelial cells in preclinical models of chronic obstructive pulmonary disease. The Manganese diPyridoxyL EthylDiamine (MnPLED)-type mangafodipir (manganese dipyridoxyl diphosphate-MnDPDP), a magnetic resonance imaging (MRI) contrast agent that possesses MnSOD mimetic activity, has shown promising results in various forms of inflammation, in preclinical as well as clinical settings. Intravenously administration of mangafodipir will, in contrast to INO, reach remote organs and may hence become an important supplement to INO. From the authors' viewpoint, it appears logical to test mangafodipr in COVID-19 patients at risk of developing life-threatening SARS-CoV-2. Five days after submission of the current manuscript, Galera Pharmaceuticals Inc. announced the dosing of the first patient in a randomized, double-blind pilot phase II clinical trial with GC4419 for COVID-19. The study was first posted on ClinicalTrials.gov (Identifier: NCT04555096) 18 September 2020.", "doi": "10.3390/antiox9100971", "pmid": "33050459", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "antiox9100971"}, {"db": "pmc", "key": "PMC7601469"}, {"db": "ClinicalTrials.gov", "key": "NCT04555096"}], "notes": [], "created": "2020-11-27T10:48:45.935Z", "modified": "2022-11-09T08:57:17.902Z"}, {"entity": "publication", "iuid": "ee9bb534c987464f94919f14262a802b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee9bb534c987464f94919f14262a802b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee9bb534c987464f94919f14262a802b"}}, "title": "A prediction model to prioritize individuals for SARS-CoV-2 test built from national symptom surveys.", "authors": [{"family": "Shoer", "given": "Saar", "initials": "S"}, {"family": "Karady", "given": "Tal", "initials": "T"}, {"family": "Keshet", "given": "Ayya", "initials": "A"}, {"family": "Shilo", "given": "Smadar", "initials": "S"}, {"family": "Rossman", "given": "Hagai", "initials": "H"}, {"family": "Gavrieli", "given": "Amir", "initials": "A"}, {"family": "Meir", "given": "Tomer", "initials": "T"}, {"family": "Lavon", "given": "Amit", "initials": "A"}, {"family": "Kolobkov", "given": "Dmitry", "initials": "D"}, {"family": "Kalka", "given": "Iris", "initials": "I"}, {"family": "Godneva", "given": "Anastasia", "initials": "A"}, {"family": "Cohen", "given": "Ori", "initials": "O"}, {"family": "Kariv", "given": "Adam", "initials": "A"}, {"family": "Hoch", "given": "Ori", "initials": "O"}, {"family": "Zer-Aviv", "given": "Mushon", "initials": "M"}, {"family": "Castel", "given": "Noam", "initials": "N"}, {"family": "Sudre", "given": "Carole", "initials": "C"}, {"family": "Zohar", "given": "Anat Ekka", "initials": "AE"}, {"family": "Irony", "given": "Angela", "initials": "A"}, {"family": "Spector", "given": "Tim", "initials": "T"}, {"family": "Geiger", "given": "Benjamin", "initials": "B"}, {"family": "Hizi", "given": "Dorit", "initials": "D"}, {"family": "Shalev", "given": "Varda", "initials": "V"}, {"family": "Balicer", "given": "Ran", "initials": "R"}, {"family": "Segal", "given": "Eran", "initials": "E"}], "type": "journal article", "published": "2020-10-10", "journal": {"title": "Med (N Y)", "issn": "2666-6340", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The gold standard for COVID-19 diagnosis is detection of viral RNA through PCR. Due to global limitations in testing capacity, effective prioritization of individuals for testing is essential.\r\n\r\nWe devised a model estimating the probability of an individual to test positive for COVID-19 based on answers to 9 simple questions that have been associated with COVID-19 infection. Our model was devised from a subsample of a national symptom survey that was answered over 2 million times in Israel in its first 2 months and a targeted survey distributed to all residents of several cities in Israel. Overall, 43,752 adults were included, from which 498 self-reported as being COVID-19 positive.\r\n\r\nOur model was validated on a held-out set of individuals from Israel where it achieved an auROC of 0.737 (CI: 0.712-0.759), auPR of 0.144 (CI: 0.119-0.177) and demonstrated its applicability outside of Israel in an independently-collected symptom survey dataset from the U.S., U.K. and Sweden.Our analyses revealed interactions between several symptoms and age, suggesting variation in the clinical manifestation of the disease in different age groups.\r\n\r\nour tool can be used online and without exposure to suspected patients, thus suggesting worldwide utility in combating COVID-19 by better directing the limited testing resources through prioritization of individuals for testing, thereby increasing the rate at which positive individuals can be identified. Moreover, individuals at high risk for a positive test result can be isolated prior to testing.", "doi": "10.1016/j.medj.2020.10.002", "pmid": "33073258", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-6340(20)30019-2"}, {"db": "pmc", "key": "PMC7547576"}], "notes": [], "created": "2020-11-27T11:50:21.127Z", "modified": "2022-11-09T08:58:28.888Z"}, {"entity": "publication", "iuid": "bb9e41d5e6b0498f97833c6922ab9c73", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb9e41d5e6b0498f97833c6922ab9c73.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb9e41d5e6b0498f97833c6922ab9c73"}}, "title": "More Than Smell-COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis.", "authors": [{"family": "Parma", "given": "Valentina", "initials": "V"}, {"family": "Ohla", "given": "Kathrin", "initials": "K"}, {"family": "Veldhuizen", "given": "Maria G", "initials": "MG"}, {"family": "Niv", "given": "Masha Y", "initials": "MY"}, {"family": "Kelly", "given": "Christine E", "initials": "CE"}, {"family": "Bakke", "given": "Alyssa J", "initials": "AJ"}, {"family": "Cooper", "given": "Keiland W", "initials": "KW"}, {"family": "Bouysset", "given": "C\u00e9dric", "initials": "C"}, {"family": "Pirastu", "given": "Nicola", "initials": "N"}, {"family": "Dibattista", "given": "Michele", "initials": "M"}, {"family": "Kaur", "given": "Rishemjit", "initials": "R"}, {"family": "Liuzza", "given": "Marco Tullio", "initials": "MT"}, {"family": "Pepino", "given": "Marta Y", "initials": "MY"}, {"family": "Sch\u00f6pf", "given": "Veronika", "initials": "V"}, {"family": "Pereda-Loth", "given": "Veronica", "initials": "V"}, {"family": "Olsson", "given": "Shannon B", "initials": "SB"}, {"family": "Gerkin", "given": "Richard C", "initials": "RC"}, {"family": "Rohlfs Dom\u00ednguez", "given": "Paloma", "initials": "P"}, {"family": "Albayay", "given": "Javier", "initials": "J"}, {"family": "Farruggia", "given": "Michael C", "initials": "MC"}, {"family": "Bhutani", "given": "Surabhi", "initials": "S"}, {"family": "Fjaeldstad", "given": "Alexander W", "initials": "AW"}, {"family": "Kumar", "given": "Ritesh", "initials": "R"}, {"family": "Menini", "given": "Anna", "initials": "A"}, {"family": "Bensafi", "given": "Moustafa", "initials": "M"}, {"family": "Sandell", "given": "Mari", "initials": "M"}, {"family": "Konstantinidis", "given": "Iordanis", "initials": "I"}, {"family": "Di Pizio", "given": "Antonella", "initials": "A"}, {"family": "Genovese", "given": "Federica", "initials": "F"}, {"family": "\u00d6zt\u00fcrk", "given": "Lina", "initials": "L"}, {"family": "Thomas-Danguin", "given": "Thierry", "initials": "T"}, {"family": "Frasnelli", "given": "Johannes", "initials": "J"}, {"family": "Boesveldt", "given": "Sanne", "initials": "S"}, {"family": "Saatci", "given": "\u00d6zlem", "initials": "\u00d6"}, {"family": "Saraiva", "given": "Luis R", "initials": "LR"}, {"family": "Lin", "given": "Cailu", "initials": "C"}, {"family": "Golebiowski", "given": "J\u00e9r\u00f4me", "initials": "J"}, {"family": "Hwang", "given": "Liang-Dar", "initials": "L"}, {"family": "Ozdener", "given": "Mehmet Hakan", "initials": "MH"}, {"family": "Gu\u00e0rdia", "given": "Maria Dolors", "initials": "MD"}, {"family": "Laudamiel", "given": "Christophe", "initials": "C"}, {"family": "Ritchie", "given": "Marina", "initials": "M"}, {"family": "Havl\u00edcek", "given": "Jan", "initials": "J"}, {"family": "Pierron", "given": "Denis", "initials": "D"}, {"family": "Roura", "given": "Eugeni", "initials": "E"}, {"family": "Navarro", "given": "Marta", "initials": "M"}, {"family": "Nolden", "given": "Alissa A", "initials": "AA"}, {"family": "Lim", "given": "Juyun", "initials": "J"}, {"family": "Whitcroft", "given": "Katherine L", "initials": "KL"}, {"family": "Colquitt", "given": "Lauren R", "initials": "LR"}, {"family": "Ferdenzi", "given": "Camille", "initials": "C"}, {"family": "Brindha", "given": "Evelyn V", "initials": "EV"}, {"family": "Altundag", "given": "Aytug", "initials": "A"}, {"family": "Macchi", "given": "Alberto", "initials": "A"}, {"family": "Nunez-Parra", "given": "Alexia", "initials": "A"}, {"family": "Patel", "given": "Zara M", "initials": "ZM"}, {"family": "Fiorucci", "given": "S\u00e9bastien", "initials": "S"}, {"family": "Philpott", "given": "Carl M", "initials": "CM"}, {"family": "Smith", "given": "Barry C", "initials": "BC"}, {"family": "Lundstr\u00f6m", "given": "Johan N", "initials": "JN"}, {"family": "Mucignat", "given": "Carla", "initials": "C"}, {"family": "Parker", "given": "Jane K", "initials": "JK"}, {"family": "van den Brink", "given": "Mirjam", "initials": "M"}, {"family": "Schmuker", "given": "Michael", "initials": "M"}, {"family": "Fischmeister", "given": "Florian Ph S", "initials": "FPS"}, {"family": "Heinbockel", "given": "Thomas", "initials": "T"}, {"family": "Shields", "given": "Vonnie D C", "initials": "VDC"}, {"family": "Faraji", "given": "Farhoud", "initials": "F"}, {"family": "Santamar\u00eda", "given": "Enrique", "initials": "E"}, {"family": "Fredborg", "given": "William E A", "initials": "WEA"}, {"family": "Morini", "given": "Gabriella", "initials": "G"}, {"family": "Olofsson", "given": "Jonas K", "initials": "JK"}, {"family": "Jalessi", "given": "Maryam", "initials": "M"}, {"family": "Karni", "given": "Noam", "initials": "N"}, {"family": "D'Errico", "given": "Anna", "initials": "A"}, {"family": "Alizadeh", "given": "Rafieh", "initials": "R"}, {"family": "Pellegrino", "given": "Robert", "initials": "R"}, {"family": "Meyer", "given": "Pablo", "initials": "P"}, {"family": "Huart", "given": "Caroline", "initials": "C"}, {"family": "Chen", "given": "Ben", "initials": "B"}, {"family": "Soler", "given": "Graciela M", "initials": "GM"}, {"family": "Alwashahi", "given": "Mohammed K", "initials": "MK"}, {"family": "Welge-L\u00fcssen", "given": "Antje", "initials": "A"}, {"family": "Freiherr", "given": "Jessica", "initials": "J"}, {"family": "de Groot", "given": "Jasper H B", "initials": "JHB"}, {"family": "Klein", "given": "Hadar", "initials": "H"}, {"family": "Okamoto", "given": "Masako", "initials": "M"}, {"family": "Singh", "given": "Preet Bano", "initials": "PB"}, {"family": "Hsieh", "given": "Julien W", "initials": "JW"}, {"family": "GCCR Group Author", "given": "", "initials": ""}, {"family": "Reed", "given": "Danielle R", "initials": "DR"}, {"family": "Hummel", "given": "Thomas", "initials": "T"}, {"family": "Munger", "given": "Steven D", "initials": "SD"}, {"family": "Hayes", "given": "John E", "initials": "JE"}], "type": "journal article", "published": "2020-10-09", "journal": {"title": "Chem Senses", "issn": "1464-3553", "issn-l": "0379-864X", "volume": "45", "issue": "7", "pages": "609-622"}, "abstract": "Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change \u00b1100) revealed a mean reduction of smell (-79.7 \u00b1 28.7, mean \u00b1 standard deviation), taste (-69.0 \u00b1 32.6), and chemesthetic (-37.3 \u00b1 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.", "doi": "10.1093/chemse/bjaa041", "pmid": "32564071", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "5860460"}, {"db": "pmc", "key": "PMC7337664"}], "notes": [], "created": "2020-12-08T16:36:10.943Z", "modified": "2021-06-17T08:27:50.863Z"}, {"entity": "publication", "iuid": "b0f0deb544914e6da3b55eb7fa321c80", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b0f0deb544914e6da3b55eb7fa321c80.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b0f0deb544914e6da3b55eb7fa321c80"}}, "title": "Beyond COVID-19-a paradigm shift in infection management?", "authors": [{"family": "Vehreschild", "given": "Maria J G T", "initials": "MJGT"}, {"family": "Tacconelli", "given": "Evelina", "initials": "E"}, {"family": "Giske", "given": "Christian G", "initials": "CG"}, {"family": "Peschel", "given": "Andreas", "initials": "A"}], "type": "letter", "published": "2020-10-09", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/S1473-3099(20)30789-1", "pmid": "33045187", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(20)30789-1"}, {"db": "pmc", "key": "PMC7546645"}], "notes": [], "created": "2020-12-01T17:16:03.841Z", "modified": "2020-12-01T17:16:03.868Z"}, {"entity": "publication", "iuid": "4f2ba3380aa140688274e008ceb51960", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4f2ba3380aa140688274e008ceb51960.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4f2ba3380aa140688274e008ceb51960"}}, "title": "A population-based cohort study of socio-demographic risk factors for COVID-19 deaths in Sweden.", "authors": [{"family": "Drefahl", "given": "Sven", "initials": "S"}, {"family": "Wallace", "given": "Matthew", "initials": "M"}, {"family": "Mussino", "given": "Eleonora", "initials": "E"}, {"family": "Aradhya", "given": "Siddartha", "initials": "S"}, {"family": "Kolk", "given": "Martin", "initials": "M"}, {"family": "Brand\u00e9n", "given": "Maria", "initials": "M"}, {"family": "Malmberg", "given": "Bo", "initials": "B"}, {"family": "Andersson", "given": "Gunnar", "initials": "G"}], "type": "journal article", "published": "2020-10-09", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "11", "issue": "1", "pages": "5097"}, "abstract": "As global deaths from COVID-19 continue to rise, the world's governments, institutions, and agencies are still working toward an understanding of who is most at risk of death. In this study, data on all recorded COVID-19 deaths in Sweden up to May 7, 2020 are linked to high-quality and accurate individual-level background data from administrative registers of the total population. By means of individual-level survival analysis we demonstrate that being male, having less individual income, lower education, not being married all independently predict a higher risk of death from COVID-19 and from all other causes of death. Being an immigrant from a low- or middle-income country predicts higher risk of death from COVID-19 but not for all other causes of death. The main message of this work is that the interaction of the virus causing COVID-19 and its social environment exerts an unequal burden on the most disadvantaged members of society.", "doi": "10.1038/s41467-020-18926-3", "pmid": "33037218", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-020-18926-3"}, {"db": "pmc", "key": "PMC7547672"}], "notes": [], "created": "2020-12-01T17:25:48.061Z", "modified": "2022-11-09T08:59:59.030Z"}, {"entity": "publication", "iuid": "6b71d3289aed493a916aaaca1fbb2ea6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b71d3289aed493a916aaaca1fbb2ea6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b71d3289aed493a916aaaca1fbb2ea6"}}, "title": "What every Researcher should know about Searching - Clarified Concepts, Search Advice, and an Agenda to improve Finding in Academia.", "authors": [{"family": "Gusenbauer", "given": "Michael", "initials": "M"}, {"family": "Haddaway", "given": "Neal R", "initials": "NR"}], "type": "journal article", "published": "2020-10-08", "journal": {"title": "Res Synth Methods", "issn": "1759-2887", "volume": null, "issue": null, "issn-l": null}, "abstract": "We researchers have taken searching for information for granted for far too long. The COVID-19 pandemic shows us the boundaries of academic searching capabilities, both in terms of our know-how and of the systems we have. With hundreds of studies published daily on COVID-19, for example, we struggle to find, stay up-to-date, and synthesize information-all hampering evidence-informed decision making. This COVID-19 information crisis is indicative of the broader problem of information overloaded academic research. To improve our finding capabilities, we urgently need to improve how we search and the systems we use. We respond to Klopfenstein and Dampier (Res Syn Meth. 2020) who commented on our 2020 paper and proposed a way of improving PubMed's and Google Scholar's search functionalities. Our response puts their commentary in a larger frame and suggests how we can improve academic searching altogether. We urge that researchers need to understand that search skills require dedicated education and training. Better and more efficient searching requires an initial understanding of the different goals that define the way searching needs to be conducted. We explain the main types of searching that we academics routinely engage in; distinguishing lookup, exploratory, and systematic searching. These three types must be conducted using different search methods (heuristics) and using search systems with specific capabilities. To improve academic searching, we introduce the \"Search Triangle\" model emphasizing the importance of matching goals, heuristics, and systems. Further, we suggest an urgently needed agenda toward search literacy as the norm in academic research and fit-for-purpose search systems.", "doi": "10.1002/jrsm.1457", "pmid": "33031639", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-01T17:31:05.757Z", "modified": "2020-12-01T17:31:05.783Z"}, {"entity": "publication", "iuid": "d94e32a234a0498cbac9b9f2af96a362", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d94e32a234a0498cbac9b9f2af96a362.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d94e32a234a0498cbac9b9f2af96a362"}}, "title": "SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden.", "authors": [{"family": "Rudberg", "given": "Ann-Sofie", "initials": "AS", "orcid": "0000-0003-3616-9943", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7acfc6023c44aa2a878fbacc3dba7fb.json"}}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c735ef404391493980e4e51d70459ce0.json"}}, {"family": "Jernbom Falk", "given": "August", "initials": "A", "orcid": "0000-0002-7773-1851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40d944d7fa964f4292f10012356a2730.json"}}, {"family": "Aguilera", "given": "Katherina", "initials": "K"}, {"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/305bca9e5c6c423898c272bf06ce2f2a.json"}}, {"family": "Gabrielsson", "given": "Lena", "initials": "L"}, {"family": "Salomonsson", "given": "Ann-Christin", "initials": "AC"}, {"family": "Hanke", "given": "Leo", "initials": "L", "orcid": "0000-0001-5514-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a35f10de4f2e4aee98278f6ab845613d.json"}}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "McInerney", "given": "Gerald", "initials": "G", "orcid": "0000-0003-2257-7241", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7770437d845444a8a07865bf5b62fab0.json"}}, {"family": "Olofsson", "given": "Jennie", "initials": "J"}, {"family": "Andersson", "given": "Eni", "initials": "E", "orcid": "0000-0002-5115-0637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8200b399e954f3482aec53a62df3b54.json"}}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C", "orcid": "0000-0003-0880-5375", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7394cf1c96945888fc8765568f5407c.json"}}, {"family": "Bayati", "given": "Shaghayegh", "initials": "S"}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Sj\u00f6berg", "given": "Ronald", "initials": "R"}, {"family": "Tegel", "given": "Hanna", "initials": "H"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1345-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a53a433db6f04a458e3d420f0c9995c5.json"}}], "type": "journal article", "published": "2020-10-08", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "11", "issue": "1", "pages": "5064"}, "abstract": "SARS-CoV-2 may pose an occupational health risk to healthcare workers. Here, we report the seroprevalence of SARS-CoV-2 antibodies, self-reported symptoms and occupational exposure to SARS-CoV-2 among healthcare workers at a large acute care hospital in Sweden. The seroprevalence of IgG antibodies against SARS-CoV-2 was 19.1% among the 2149 healthcare workers recruited between April 14th and May 8th 2020, which was higher than the reported regional seroprevalence during the same time period. Symptoms associated with seroprevalence were anosmia (odds ratio (OR) 28.4, 95% CI 20.6-39.5) and ageusia (OR 19.2, 95% CI 14.3-26.1). Seroprevalence was also associated with patient contact (OR 2.9, 95% CI 1.9-4.5) and covid-19 patient contact (OR 3.3, 95% CI 2.2-5.3). These findings imply an occupational risk for SARS-CoV-2 infection among healthcare workers. Continued measures are warranted to assure healthcare workers safety and reduce transmission from healthcare workers to patients and to the community.", "doi": "10.1038/s41467-020-18848-0", "pmid": "33033249", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Funder: H2020": null, "Category: Health": null, "Category: Serology": null}, "xrefs": [{"db": "pmc", "key": "PMC7544689"}, {"db": "pii", "key": "10.1038/s41467-020-18848-0"}], "notes": [], "created": "2020-10-30T11:46:40.143Z", "modified": "2023-06-19T14:24:22.660Z"}, {"entity": "publication", "iuid": "7c590b4e9a234f918c74726c082da341", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7c590b4e9a234f918c74726c082da341.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7c590b4e9a234f918c74726c082da341"}}, "title": "Living with the COVID-19 pandemic: act now with the tools we have.", "authors": [{"family": "Bedford", "given": "Juliet", "initials": "J"}, {"family": "Enria", "given": "Delia", "initials": "D"}, {"family": "Giesecke", "given": "Johan", "initials": "J"}, {"family": "Heymann", "given": "David L", "initials": "DL"}, {"family": "Ihekweazu", "given": "Chikwe", "initials": "C"}, {"family": "Kobinger", "given": "Gary", "initials": "G"}, {"family": "Lane", "given": "H Clifford", "initials": "HC"}, {"family": "Memish", "given": "Ziad A", "initials": "ZA"}, {"family": "Oh", "given": "Myoung-Don", "initials": "MD"}, {"family": "Sall", "given": "Amadou Alpha", "initials": "AA"}, {"family": "Ungchusak", "given": "Kumnuan", "initials": "K"}, {"family": "Wieler", "given": "Lothar H", "initials": "LH"}, {"family": "WHO Strategic and Technical Advisory Group for Infectious Hazards", "given": "", "initials": ""}], "type": "journal article", "published": "2020-10-08", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": null, "issue": null, "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)32117-6", "pmid": "33038947", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)32117-6"}, {"db": "pmc", "key": "PMC7544497"}], "notes": [], "created": "2020-12-01T17:21:13.505Z", "modified": "2020-12-01T17:21:13.515Z"}, {"entity": "publication", "iuid": "64e939415762403c9009f86ec14f76ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/64e939415762403c9009f86ec14f76ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/64e939415762403c9009f86ec14f76ef"}}, "title": "Intravenous immunoglobulin therapy in COVID-19-related encephalopathy.", "authors": [{"family": "Muccioli", "given": "Lorenzo", "initials": "L"}, {"family": "Pensato", "given": "Umberto", "initials": "U"}, {"family": "Bernab\u00e8", "given": "Giorgia", "initials": "G"}, {"family": "Ferri", "given": "Lorenzo", "initials": "L"}, {"family": "Tappat\u00e0", "given": "Maria", "initials": "M"}, {"family": "Volpi", "given": "Lilia", "initials": "L"}, {"family": "Cani", "given": "Ilaria", "initials": "I"}, {"family": "Henry", "given": "Olivia J", "initials": "OJ"}, {"family": "Ceccaroni", "given": "Francesca", "initials": "F"}, {"family": "Cevoli", "given": "Sabina", "initials": "S"}, {"family": "Stofella", "given": "Gloria", "initials": "G"}, {"family": "Pasini", "given": "Elena", "initials": "E"}, {"family": "Fornaro", "given": "Giacomo", "initials": "G"}, {"family": "Tonon", "given": "Caterina", "initials": "C"}, {"family": "Vidale", "given": "Simone", "initials": "S"}, {"family": "Liguori", "given": "Rocco", "initials": "R"}, {"family": "Tinuper", "given": "Paolo", "initials": "P"}, {"family": "Michelucci", "given": "Roberto", "initials": "R"}, {"family": "Cortelli", "given": "Pietro", "initials": "P"}, {"family": "Bisulli", "given": "Francesca", "initials": "F"}], "type": "journal article", "published": "2020-10-08", "journal": {"title": "J Neurol", "issn": "1432-1459", "volume": null, "issue": null, "issn-l": null}, "abstract": "To report on efficacy and safety of intravenous immunoglobulin (IVIg) therapy in a case series of patients with COVID-19-related encephalopathy.\n\nWe retrospectively collected data on all patients with COVID-19 hospitalized at two Italian hospitals who developed encephalopathy during disease course and were treated with IVIg.\n\nFive patients (two females, mean age 66.8 years) developed encephalopathy after a mean of 12.6 days, since the onset of respiratory/constitutional symptoms related to COVID-19. Four patients suffered severe respiratory distress, three of which required invasive mechanical ventilation. Neurological manifestations included impaired consciousness, agitation, delirium, pyramidal and extrapyramidal signs. EEG demonstrated diffuse slowing in all patients. Brain MRI showed non-specific findings. CSF analysis revealed normal cell count and protein levels. In all subjects, RT-PCR for SARS-CoV-2 in CSF tested negative. IVIg at 0.4 g/kg/die was commenced 29.8 days (mean, range: 19-55 days) after encephalopathy onset, leading to complete electroclinical recovery in all patients, with an initial improvement of neuropsychiatric symptoms observed in 3.4 days (mean, range: 1-10 days). No adverse events related to IVIg were observed.\n\nOur preliminary findings suggest that IVIg may represent a safe and effective treatment for COVID-19-associated encephalopathy. Clinical efficacy may be driven by the anti-inflammatory action of IVIg, associated with its anti-cytokine qualities.", "doi": "10.1007/s00415-020-10248-0", "pmid": "33030607", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00415-020-10248-0"}, {"db": "pmc", "key": "PMC7543032"}], "notes": [], "created": "2020-12-01T17:32:59.107Z", "modified": "2021-02-26T08:45:48.261Z"}, {"entity": "publication", "iuid": "b327cae0f4e3414480b4ac802d8a4bd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b327cae0f4e3414480b4ac802d8a4bd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b327cae0f4e3414480b4ac802d8a4bd0"}}, "title": "Airborne spread of infectious SARS-CoV-2: Moving forward using lessons from SARS-CoV and MERS-CoV.", "authors": [{"family": "da Silva", "given": "Priscilla Gomes", "initials": "PG"}, {"family": "Nascimento", "given": "Maria S\u00e3o Jos\u00e9", "initials": "MSJ"}, {"family": "Soares", "given": "Ruben R G", "initials": "RRG"}, {"family": "Sousa", "given": "Sofia I V", "initials": "SIV"}, {"family": "Mesquita", "given": "Jo\u00e3o R", "initials": "JR"}], "type": "journal article", "published": "2020-10-08", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "volume": null, "issue": null, "pages": "142802", "issn-l": "0048-9697"}, "abstract": "Although an increasing body of data reports the detection of SARS-CoV-2 RNA in air, this does not correlate to the presence of infectious viruses, thus not evaluating the risk for airborne COVID-19. Hence there is a marked knowledge gap that requires urgent attention. Therefore, in this systematic review, viability/stability of airborne SARS-CoV-2, SARS-CoV and MERS-CoV viruses is discussed.\n\nA systematic literature review was performed on PubMed/MEDLINE, Web of Science and Scopus to assess the stability and viability of SARS-CoV, MERS-CoV and SARS-CoV-2 on air samples.\n\nThe initial search identified 27 articles. Following screening of titles and abstracts and removing duplicates, 11 articles were considered relevant. Temperatures ranging from 20 \u00b0C to 25 \u00b0C and relative humidity ranging from 40% to 50% were reported to have a protective effect on viral viability for airborne SARS-CoV and MERS-CoV. As no data is yet available on the conditions influencing viability for airborne SARS-CoV-2, and given the genetic similarity to SARS-CoV and MERS-CoV, one could extrapolate that the same conditions would apply. Nonetheless, the effect of these conditions seems to be residual considering the increasing number of cases in the south of USA, Brazil and India, where high temperatures and humidities have been observed.\n\nHigher temperatures and high relative humidity can have a modest effect on SARS-CoV-2 viability in the environment, as reported in previous studies to this date. However, these studies are experimental, and do not support the fact that the virus has efficiently spread in the tropical regions of the globe, with other transmission routes such as the contact and droplet ones probably being responsible for the majority of cases reported in these regions, along with other factors such as human mobility patterns and contact rates. Further studies are needed to investigate the extent of aerosol transmission of SARS-CoV-2 as this would have important implications for public health and infection-control policies.", "doi": "10.1016/j.scitotenv.2020.142802", "pmid": "33071145", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(20)36331-2"}, {"db": "pmc", "key": "PMC7543729"}], "notes": [], "created": "2020-11-27T11:51:35.091Z", "modified": "2020-12-01T17:05:19.632Z"}, {"entity": "publication", "iuid": "25657ae6d3c7476b9a979baf93ddb9f3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/25657ae6d3c7476b9a979baf93ddb9f3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/25657ae6d3c7476b9a979baf93ddb9f3"}}, "title": "Psychological distress among Iranian health-care providers exposed to coronavirus disease 2019 (COVID-19): a qualitative study.", "authors": [{"family": "Alizadeh", "given": "Azizeh", "initials": "A"}, {"family": "Khankeh", "given": "Hamid Reza", "initials": "HR"}, {"family": "Barati", "given": "Mohammad", "initials": "M"}, {"family": "Ahmadi", "given": "Yazdan", "initials": "Y"}, {"family": "Hadian", "given": "Arash", "initials": "A"}, {"family": "Azizi", "given": "Maryam", "initials": "M"}], "type": "journal article", "published": "2020-10-07", "journal": {"title": "BMC Psychiatry", "issn": "1471-244X", "issn-l": null, "volume": "20", "issue": "1", "pages": "494"}, "abstract": "Novel corona virus, named COVID-19, has spread rapidly to other countries like Italy, Iran and South Korea and affected all people, especially health-care providers. Therefore, due to the rapid spread of the disease in Iran, the aim of the present study was to explore psychological distress experienced by Iranian health-care providers in the first few weeks of the corona virus outbreak.\r\n\r\nThe present qualitative study was conducted on 18 Iranian health-care providers exposed to COVID - 19 using a content analysis method. Purposeful sampling was used to select the participants and continued until data saturation was reached. Data were collected using semi-structured interviews and then the qualitative data were analyzed through direct content analysis.\r\n\r\nBy analyzing 236 primary codes, two main categories were extracted from the experiences of health-care providers during corona virus outbreak. The first category included Occupational demands with three sub-categories: nature of illness, Organizational demands and social demands. The second category was Supportive resources included personal support and social support.\r\n\r\nThe results of this study found that there were some barriers and challenges to medical personnel exposed to COVID-19 that caused psychological distress. Some of these problems related to the nature of illness, others related to social and organizational demands and some of supportive resources buffer the relationship between occupational demands and psychological distress.", "doi": "10.1186/s12888-020-02889-2", "pmid": "33028290", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12888-020-02889-2"}, {"db": "pmc", "key": "PMC7538532"}], "notes": [], "created": "2020-12-03T08:51:27.977Z", "modified": "2022-11-09T09:00:38.111Z"}, {"entity": "publication", "iuid": "932740d940544f29a914b99552819522", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/932740d940544f29a914b99552819522.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/932740d940544f29a914b99552819522"}}, "title": "Were clinical routines for good end-of-life care maintained in hospitals and nursing homes during the first three months of the outbreak of COVID-19? A national register study.", "authors": [{"family": "Martinsson", "given": "Lisa", "initials": "L"}, {"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "Bergstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Staffan", "initials": "S"}], "type": "journal article", "published": "2020-10-06", "journal": {"title": "J Pain Symptom Manage", "issn": "1873-6513", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Although the COVID-19 pandemic might affect important clinical routines, few studies have focused on the maintenance of good quality in end-of-life care.\r\n\r\nThe objective was to examine whether adherence to clinical routines for good end-of-life care differed for deaths due to COVID-19 compared to a reference cohort from 2019, and whether they differed between nursing homes and hospitals.\r\n\r\nData about five items reflecting clinical routines for persons who died an expected death from COVID-19 during the first three months of the pandemic (March-May 2020) were collected from the Swedish Register of Palliative Care. The items were compared between the COVID-19 group and the reference cohort, and between the nursing home and hospital COVID-19 deaths.\r\n\r\n1316 expected deaths were identified in nursing homes and 685 in hospitals. Four of the five items differed for total COVID-19 group compared to the reference cohort: fewer were examined by a physician during the last days before death, pain and oral health were less likely to be assessed, and fewer had had a specialised palliative care team consultation (p < .0001, respectively). Assessment of symptoms other than pain did not differ significantly. The five items differed between the nursing homes and hospitals in the COVID-19 group, most notably regarding the proportion of persons examined by a physician during the last days (nursing homes - 18%, hospitals - 100%).\r\n\r\nThis national register study shows that several clinical routines for end-of-life care did not meet the usual standards during the first three months of the COVID-19 pandemic in Sweden. Higher preparedness for and monitoring of end-of-life care quality should be integrated into future pandemic plans.", "doi": "10.1016/j.jpainsymman.2020.09.043", "pmid": "33035649", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0885-3924(20)30794-6"}, {"db": "pmc", "key": "PMC7538392"}], "notes": [], "created": "2020-12-01T17:29:08.233Z", "modified": "2021-02-26T08:47:00.076Z"}, {"entity": "publication", "iuid": "5df1142a5d38410a8a9d94601249e1fe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5df1142a5d38410a8a9d94601249e1fe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5df1142a5d38410a8a9d94601249e1fe"}}, "title": "Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study.", "authors": [{"family": "Burn", "given": "Edward", "initials": "E"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Abedtash", "given": "Hamed", "initials": "H"}, {"family": "Abrah\u00e3o", "given": "Maria Tereza F", "initials": "MTF"}, {"family": "Alberga", "given": "Amanda", "initials": "A"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Aragon", "given": "Maria", "initials": "M"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Banda", "given": "Juan M", "initials": "JM"}, {"family": "Cho", "given": "Jaehyeong", "initials": "J"}, {"family": "Culhane", "given": "Aedin C", "initials": "AC"}, {"family": "Davydov", "given": "Alexander", "initials": "A"}, {"family": "DeFalco", "given": "Frank J", "initials": "FJ"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "DuVall", "given": "Scott", "initials": "S"}, {"family": "Falconer", "given": "Thomas", "initials": "T"}, {"family": "Fernandez-Bertolin", "given": "Sergio", "initials": "S"}, {"family": "Gao", "given": "Weihua", "initials": "W"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Hardin", "given": "Jill", "initials": "J"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Huser", "given": "Vojtech", "initials": "V"}, {"family": "Jeon", "given": "Hokyun", "initials": "H"}, {"family": "Jing", "given": "Yonghua", "initials": "Y"}, {"family": "Jung", "given": "Chi Young", "initials": "CY"}, {"family": "Kaas-Hansen", "given": "Benjamin Skov", "initials": "BS"}, {"family": "Kaduk", "given": "Denys", "initials": "D"}, {"family": "Kent", "given": "Seamus", "initials": "S"}, {"family": "Kim", "given": "Yeesuk", "initials": "Y"}, {"family": "Kolovos", "given": "Spyros", "initials": "S"}, {"family": "Lane", "given": "Jennifer C E", "initials": "JCE"}, {"family": "Lee", "given": "Hyejin", "initials": "H"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Makadia", "given": "Rupa", "initials": "R"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Mehta", "given": "Paras P", "initials": "PP"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Natarajan", "given": "Karthik", "initials": "K"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Park", "given": "Rae Woong", "initials": "RW"}, {"family": "Park", "given": "Jimyung", "initials": "J"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A"}, {"family": "Rao", "given": "Gowtham", "initials": "G"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Rho", "given": "Yeunsook", "initials": "Y"}, {"family": "Rijnbeek", "given": "Peter", "initials": "P"}, {"family": "Schilling", "given": "Lisa M", "initials": "LM"}, {"family": "Schuemie", "given": "Martijn", "initials": "M"}, {"family": "Shah", "given": "Nigam H", "initials": "NH"}, {"family": "Shoaibi", "given": "Azza", "initials": "A"}, {"family": "Song", "given": "Seokyoung", "initials": "S"}, {"family": "Spotnitz", "given": "Matthew", "initials": "M"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Swerdel", "given": "Joel N", "initials": "JN"}, {"family": "Vizcaya", "given": "David", "initials": "D"}, {"family": "Volpe", "given": "Salvatore", "initials": "S"}, {"family": "Wen", "given": "Haini", "initials": "H"}, {"family": "Williams", "given": "Andrew E", "initials": "AE"}, {"family": "Yimer", "given": "Belay B", "initials": "BB"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhuk", "given": "Oleg", "initials": "O"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}], "type": "journal article", "published": "2020-10-06", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "11", "issue": "1", "pages": "5009"}, "abstract": "Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. Here, we describe the characteristics of adults hospitalised with COVID-19 and compare them with influenza patients. We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) COVID-19 patients, summarising between 4811 and 11,643 unique aggregate characteristics. COVID-19 patients have been majority male in the US and Spain, but predominantly female in South Korea. Age profiles vary across data sources. Compared to 84,585 individuals hospitalised with influenza in 2014-19, COVID-19 patients have more typically been male, younger, and with fewer comorbidities and lower medication use. While protecting groups vulnerable to influenza is likely a useful starting point in the response to COVID-19, strategies will likely need to be broadened to reflect the particular characteristics of individuals being hospitalised with COVID-19.", "doi": "10.1038/s41467-020-18849-z", "pmid": "33024121", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-020-18849-z"}, {"db": "pmc", "key": "PMC7538555"}, {"db": "URL", "key": "http://evidence.ohdsi.org/Covid19CharacterizationHospitalization/.", "description": "http://evidence.ohdsi.org/Covid19CharacterizationHospitalization/."}, {"db": "URL", "key": "https://github.com/ohdsi-studies/Covid19HospitalizationCharacterization", "description": "https://github.com/ohdsi-studies/Covid19HospitalizationCharacterization"}], "notes": [], "created": "2020-11-27T12:39:00.134Z", "modified": "2023-01-13T09:49:38.516Z"}, {"entity": "publication", "iuid": "ec79c7a6fc0447b285f5e0f27b17d2ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec79c7a6fc0447b285f5e0f27b17d2ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec79c7a6fc0447b285f5e0f27b17d2ff"}}, "title": "Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2.", "authors": [{"family": "Rogstam", "given": "Annika", "initials": "A"}, {"family": "Nyblom", "given": "Maria", "initials": "M"}, {"family": "Christensen", "given": "Signe", "initials": "S"}, {"family": "Sele", "given": "Celeste", "initials": "C"}, {"family": "Talibov", "given": "Vladimir O", "initials": "VO"}, {"family": "Lindvall", "given": "Therese", "initials": "T"}, {"family": "Rasmussen", "given": "Anna Andersson", "initials": "AA"}, {"family": "Andr\u00e9", "given": "Ingemar", "initials": "I"}, {"family": "Fisher", "given": "Zo\u00eb", "initials": "Z"}, {"family": "Knecht", "given": "Wolfgang", "initials": "W"}, {"family": "Kozielski", "given": "Frank", "initials": "F"}], "type": "journal article", "published": "2020-10-06", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "21", "issue": "19", "issn-l": null}, "abstract": "Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), causing Coronavirus Disease 19 (COVID-19), emerged at the end of 2019 and quickly spread to cause a global pandemic with severe socio-economic consequences. The early sequencing of its RNA genome revealed its high similarity to SARS, likely to have originated from bats. The SARS-CoV-2 non-structural protein 10 (nsp10) displays high sequence similarity with its SARS homologue, which binds to and stimulates the 3'-to-5' exoribonuclease and the 2'-O-methlytransferase activities of nsps 14 and 16, respectively. Here, we report the biophysical characterization and 1.6 \u00c5 resolution structure of the unbound form of nsp10 from SARS-CoV-2 and compare it to the structures of its SARS homologue and the complex-bound form with nsp16 from SARS-CoV-2. The crystal structure and solution behaviour of nsp10 will not only form the basis for understanding the role of SARS-CoV-2 nsp10 as a central player of the viral RNA capping apparatus, but will also serve as a basis for the development of inhibitors of nsp10, interfering with crucial functions of the replication-transcription complex and virus replication.", "doi": "10.3390/ijms21197375", "pmid": "33036230", "labels": {"Type: Journal article": null, "Category: Proteins": null}, "xrefs": [{"db": "PDB", "key": "6ZPE", "description": "Nonstructural protein 10 (nsp10) from SARS CoV-2, 1.58\u00c5 resolution"}, {"db": "PDB", "key": "6ZCT", "description": "Nonstructural protein 10 (nsp10) from SARS CoV-2, 2.55\u00c5 resolution"}, {"db": "URL", "key": "http://www.mdpi.com/1422-0067/21/19/7375/s1", "description": "Supplementary materials"}], "notes": [], "created": "2020-10-30T11:23:12.306Z", "modified": "2021-02-26T08:47:18.875Z"}, {"entity": "publication", "iuid": "0846f729bebd46bab1412900525f7e54", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0846f729bebd46bab1412900525f7e54.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0846f729bebd46bab1412900525f7e54"}}, "title": "Upper Respiratory Tract Levels of Severe Acute Respiratory Syndrome Coronavirus 2 RNA and Duration of Viral RNA Shedding Do Not Differ Between Patients With Mild and Severe/Critical Coronavirus Disease 2019", "authors": [{"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Marklund", "given": "Emelie", "initials": "E"}, {"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Andersson", "given": "Lars Magnus", "initials": "LM"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal-article", "published": "2020-10-05", "journal": {"title": "The Journal of Infectious Diseases", "issn": "0022-1899", "issn-l": null, "volume": "223", "issue": "1", "pages": "15-18"}, "abstract": "This study reports longitudinal viral RNA loads from the nasopharynx/throat in patients with mild and severe/critical coronavirus disease 2019 (COVID-19). We also investigated whether the duration of symptoms correlated with the duration of viral RNA shedding. A total of 56 patients were included. The highest viral loads occurred early after onset of symptoms. Neither the viral RNA loads in the upper respiratory tract nor the time to viral RNA clearance differed between patients with mild or severe/critical disease. There was a moderate correlation between number of days with symptoms and number of days with viral RNA shedding in patients with mild COVID-19.", "doi": "10.1093/infdis/jiaa632", "pmid": "33020822", "labels": {"Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Research Area: Biomarkers and systems immunology": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Genomics & transcriptomics": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-04T07:31:41.074Z", "modified": "2021-06-14T14:40:59.081Z"}, {"entity": "publication", "iuid": "f328480b01e246b5a1721e85548a034f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f328480b01e246b5a1721e85548a034f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f328480b01e246b5a1721e85548a034f"}}, "title": "Testing wastewater to detect severe acute respiratory syndrome coronavirus 2 in communities.", "authors": [{"family": "Harries", "given": "Anthony D", "initials": "AD"}, {"family": "Dar Berger", "given": "Selma", "initials": "S"}, {"family": "Satyanarayana", "given": "Srinath", "initials": "S"}, {"family": "Thekkur", "given": "Pruthu", "initials": "P"}, {"family": "Kumar", "given": "Ajay M V", "initials": "AMV"}], "type": "journal article", "published": "2020-10-05", "journal": {"title": "Trans R Soc Trop Med Hyg", "issn": "1878-3503", "volume": "114", "issue": "10", "pages": "782-783", "issn-l": null}, "abstract": "Research groups around the world are starting to analyse whether wastewater surveillance is a useful tool to monitor the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in communities. Reported studies from the Netherlands, USA, Australia and France have demonstrated that SARS-CoV-2 can be detected and quantified in wastewater, allowing the total number of community infections to be estimated as well as monitoring whether the virus has returned to a community after elimination. Further work is required to improve the quantification of virus, to better detect the virus at low levels and to ensure wastewater samples are representative of the community under surveillance.", "doi": "10.1093/trstmh/traa066", "pmid": "32780856", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "5891256"}, {"db": "pmc", "key": "PMC7454889"}], "notes": [], "created": "2020-12-07T13:32:00.162Z", "modified": "2021-02-26T08:46:13.601Z"}, {"entity": "publication", "iuid": "84b42d7543d34c9ea1ffec8a3f923dd5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84b42d7543d34c9ea1ffec8a3f923dd5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84b42d7543d34c9ea1ffec8a3f923dd5"}}, "title": "Comparing biomarkers for COVID-19 disease with commonly associated preexisting conditions and complications", "authors": [{"family": "Huang", "given": "Jesse", "initials": "J"}], "type": "posted-content", "published": "2020-10-05", "journal": {"title": "", "issn": null, "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1101/2020.10.02.20205609", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-09T19:34:36.434Z", "modified": "2021-06-09T19:34:49.113Z"}, {"entity": "publication", "iuid": "6564dde888cc467cbb4dcb65121bbd2d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6564dde888cc467cbb4dcb65121bbd2d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6564dde888cc467cbb4dcb65121bbd2d"}}, "title": "Safety and efficacy of the Russian COVID-19 vaccine: more information needed.", "authors": [{"family": "Bucci", "given": "Enrico", "initials": "E"}, {"family": "Andreev", "given": "Konstantin", "initials": "K"}, {"family": "Bj\u00f6rkman", "given": "Anders", "initials": "A"}, {"family": "Calogero", "given": "Raffaele Adolfo", "initials": "RA"}, {"family": "Carafoli", "given": "Ernesto", "initials": "E"}, {"family": "Carninci", "given": "Piero", "initials": "P"}, {"family": "Castagnoli", "given": "Paola", "initials": "P"}, {"family": "Cossarizza", "given": "Andrea", "initials": "A"}, {"family": "Mussini", "given": "Cristina", "initials": "C"}, {"family": "Guerin", "given": "Philippe", "initials": "P"}, {"family": "Lipworth", "given": "Brian", "initials": "B"}, {"family": "Sbardella", "given": "Gianluca", "initials": "G"}, {"family": "Stocki", "given": "Teresa", "initials": "T"}, {"family": "Tuosto", "given": "Loretta", "initials": "L"}, {"family": "van Tulleken", "given": "Christoffer", "initials": "C"}, {"family": "Viola", "given": "Antonella", "initials": "A"}], "type": "letter", "published": "2020-10-03", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "396", "issue": "10256", "pages": "e53", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)31960-7", "pmid": "32971041", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31960-7"}, {"db": "pmc", "key": "PMC7503114"}], "notes": [], "created": "2020-12-03T15:08:12.915Z", "modified": "2020-12-03T15:08:12.925Z"}, {"entity": "publication", "iuid": "ca305314e9bd443b94b3913fca99e324", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ca305314e9bd443b94b3913fca99e324.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ca305314e9bd443b94b3913fca99e324"}}, "title": "Improving on and assessing ethical guidelines for digital tracking and tracing systems for pandemics.", "authors": [{"family": "Lundgren", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2020-10-03", "journal": {"title": "Ethics Inf Technol", "issn": "1388-1957", "volume": null, "issue": null, "pages": "1-4", "issn-l": null}, "abstract": "So-called digital tracking and tracing systems (DTTSs) have been proposed as a means to prevent the spread of SARS-CoV-2. There are ethical guidelines and evaluations of such systems available. As part of a research project, I will build on and critically evaluate the foundations of such guidelines. The goal is to provide both incremental improvements of the specific requirements for DTTSs and to present and discuss more fundamental challenge, the risk for indirect effects and slippery slopes. The nature of slippery slopes makes ethical guidelines more difficult since it requires a more complex analysis than, for example, using a checklist allows for.", "doi": "10.1007/s10676-020-09561-z", "pmid": "33041647", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "9561"}, {"db": "pmc", "key": "PMC7532338"}], "notes": [], "created": "2020-12-01T17:20:29.348Z", "modified": "2020-12-01T17:20:29.360Z"}, {"entity": "publication", "iuid": "7b1e089b1173446884e09c71f0a18d9e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b1e089b1173446884e09c71f0a18d9e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b1e089b1173446884e09c71f0a18d9e"}}, "title": "The worldwide clinical trial research response to the COVID-19 pandemic - the first 100 days.", "authors": [{"family": "Janiaud", "given": "Perrine", "initials": "P"}, {"family": "Axfors", "given": "Cathrine", "initials": "C"}, {"family": "Van't Hooft", "given": "Janneke", "initials": "J"}, {"family": "Saccilotto", "given": "Ramon", "initials": "R"}, {"family": "Agarwal", "given": "Arnav", "initials": "A"}, {"family": "Appenzeller-Herzog", "given": "Christian", "initials": "C"}, {"family": "Contopoulos-Ioannidis", "given": "Despina G", "initials": "DG"}, {"family": "Danchev", "given": "Valentin", "initials": "V"}, {"family": "Dirnagl", "given": "Ulrich", "initials": "U"}, {"family": "Ewald", "given": "Hannah", "initials": "H"}, {"family": "Gartlehner", "given": "Gerald", "initials": "G"}, {"family": "Goodman", "given": "Steven N", "initials": "SN"}, {"family": "Haber", "given": "Noah A", "initials": "NA"}, {"family": "Ioannidis", "given": "Angeliki Diotima", "initials": "AD"}, {"family": "Ioannidis", "given": "John P A", "initials": "JPA"}, {"family": "Lythgoe", "given": "Mark P", "initials": "MP"}, {"family": "Ma", "given": "Wenyan", "initials": "W"}, {"family": "Macleod", "given": "Malcolm", "initials": "M"}, {"family": "Mali\u010dki", "given": "Mario", "initials": "M"}, {"family": "Meerpohl", "given": "Joerg J", "initials": "JJ"}, {"family": "Min", "given": "Yan", "initials": "Y"}, {"family": "Moher", "given": "David", "initials": "D"}, {"family": "Nagavci", "given": "Blin", "initials": "B"}, {"family": "Naudet", "given": "Florian", "initials": "F"}, {"family": "Pauli-Magnus", "given": "Christiane", "initials": "C"}, {"family": "O'Sullivan", "given": "Jack W", "initials": "JW"}, {"family": "Riedel", "given": "Nico", "initials": "N"}, {"family": "Roth", "given": "Jan A", "initials": "JA"}, {"family": "Sauermann", "given": "Mandy", "initials": "M"}, {"family": "Schandelmaier", "given": "Stefan", "initials": "S"}, {"family": "Schmitt", "given": "Andreas M", "initials": "AM"}, {"family": "Speich", "given": "Benjamin", "initials": "B"}, {"family": "Williamson", "given": "Paula R", "initials": "PR"}, {"family": "Hemkens", "given": "Lars G", "initials": "LG"}], "type": "journal article", "published": "2020-10-02", "journal": {"title": "F1000Res", "issn": "2046-1402", "issn-l": "2046-1402", "volume": "9", "issue": null, "pages": "1193"}, "abstract": "Background: Never before have clinical trials drawn as much public attention as those testing interventions for COVID-19. We aimed to describe the worldwide COVID-19 clinical research response and its evolution over the first 100 days of the pandemic. Methods: Descriptive analysis of planned, ongoing or completed trials by April 9, 2020 testing any intervention to treat or prevent COVID-19, systematically identified in trial registries, preprint servers, and literature databases. A survey was conducted of all trials to assess their recruitment status up to July 6, 2020. Results: Most of the 689 trials (overall target sample size 396,366) were small (median sample size 120; interquartile range [IQR] 60-300) but randomized (75.8%; n=522) and were often conducted in China (51.1%; n=352) or the USA (11%; n=76). 525 trials (76.2%) planned to include 155,571 hospitalized patients, and 25 (3.6%) planned to include 96,821 health-care workers. Treatments were evaluated in 607 trials (88.1%), frequently antivirals (n=144) or antimalarials (n=112); 78 trials (11.3%) focused on prevention, including 14 vaccine trials. No trial investigated social distancing. Interventions tested in 11 trials with >5,000 participants were also tested in 169 smaller trials (median sample size 273; IQR 90-700). Hydroxychloroquine alone was investigated in 110 trials. While 414 trials (60.0%) expected completion in 2020, only 35 trials (4.1%; 3,071 participants) were completed by July 6. Of 112 trials with detailed recruitment information, 55 had recruited <20% of the targeted sample; 27 between 20-50%; and 30 over 50% (median 14.8% [IQR 2.0-62.0%]). Conclusions: The size and speed of the COVID-19 clinical trials agenda is unprecedented. However, most trials were small investigating a small fraction of treatment options. The feasibility of this research agenda is questionable, and many trials may end in futility, wasting research resources. Much better coordination is needed to respond to global health threats.", "doi": "10.12688/f1000research.26707.2", "pmid": "33082937", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7539080.2"}], "notes": [], "created": "2020-11-19T19:33:08.731Z", "modified": "2022-11-09T09:01:59.475Z"}, {"entity": "publication", "iuid": "0b339525d3774ee0bbe33c3f9eb82687", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b339525d3774ee0bbe33c3f9eb82687.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b339525d3774ee0bbe33c3f9eb82687"}}, "title": "The COVID-19 outbreak and approaches to performing EEG in Europe.", "authors": [{"family": "Krysl", "given": "David", "initials": "D"}, {"family": "Beniczky", "given": "S\u00e1ndor", "initials": "S"}, {"family": "Franceschetti", "given": "Silvana", "initials": "S"}, {"family": "Arzimanoglou", "given": "Alexis", "initials": "A"}], "type": "journal article", "published": "2020-10-01", "journal": {"title": "Epileptic Disord", "issn": "1950-6945", "issn-l": null, "volume": "22", "issue": "5", "pages": "548-554"}, "abstract": "The coronavirus SARS-CoV-2 disease (COVID-19) pandemic affects availability and performance of neurophysiological diagnostic methods, including EEG. Our objective was to outline the current situation regarding EEG-based investigations across Europe. A web-based survey was distributed to centres within the European Reference Network on rare and complex epilepsies (ERN EpiCARE). Responses were collected between April 9 and May 15, 2020. Results were analysed with Microsoft Excel, Python Pandas and SciPy. Representants from 47 EpiCARE centres from 22 countries completed the survey. At the time of completing the survey, inpatient video-EEGs had been stopped or restricted in most centres (61.7% vs. 36.2% for adults, and 38.3% vs. 53.2% for children). Invasive investigations and epilepsy surgery were similarly affected. Acute EEGs continued to be performed, while indications for outpatient EEGs were limited and COVID-19 triage put in place. The strictness of measures varied according to extent of the outbreak in a given country. The results indicate a profound impact of COVID-19 on neurophysiological diagnostics, especially inpatient video-EEGs, invasive investigations, and epilepsy surgery. The COVID-19 pandemic may hamper care for patients in need of EEG-based investigations, particularly patients with seizure disorders. ERN EpiCARE will work on recommendations on how to rapidly adapt to such situations in order to alleviate consequences for our patients.", "doi": "10.1684/epd.2020.1208", "pmid": "33095171", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "epd.2020.1208"}], "notes": [], "created": "2020-12-01T15:35:43.413Z", "modified": "2021-02-26T08:46:12.902Z"}, {"entity": "publication", "iuid": "3714d5962dfe4aa4bed16288c686fa97", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3714d5962dfe4aa4bed16288c686fa97.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3714d5962dfe4aa4bed16288c686fa97"}}, "title": "Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19.", "authors": [{"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "Perez-Potti", "given": "Andr\u00e9", "initials": "A"}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Gorin", "given": "Jean-Baptiste", "initials": "J"}, {"family": "Olsson", "given": "Annika", "initials": "A"}, {"family": "Llewellyn-Lacey", "given": "Sian", "initials": "S"}, {"family": "Kamal", "given": "Habiba", "initials": "H"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Wullimann", "given": "David J", "initials": "DJ"}, {"family": "Kammann", "given": "Tobias", "initials": "T"}, {"family": "Emg\u00e5rd", "given": "Johanna", "initials": "J"}, {"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Folkesson", "given": "Elin", "initials": "E"}, {"family": "Karolinska COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Henter", "given": "Jan-Inge", "initials": "J"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Allander", "given": "Tobias", "initials": "T"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Nielsen", "given": "Morten", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Price", "given": "David A", "initials": "DA"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}], "type": "journal article", "published": "2020-10-01", "journal": {"title": "Cell", "issn": "1097-4172", "issn-l": "0092-8674", "volume": "183", "issue": "1", "pages": "158-168.e14"}, "abstract": "SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.", "doi": "10.1016/j.cell.2020.08.017", "pmid": "32979941", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Genomics & transcriptomics": null, "Category: Other": null, "Category: Proteins": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.1016/j.cell.2020.08.017", "description": "Supplementary materials: predicted binding affinities, donor characteristics, sample information, and some analyses"}, {"db": "NA", "key": "All data included in the paper", "description": null}], "notes": [], "created": "2020-10-28T09:03:34.190Z", "modified": "2021-11-18T09:21:57.000Z"}, {"entity": "publication", "iuid": "ea5eacb93e4747ee98374542036f42a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ea5eacb93e4747ee98374542036f42a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ea5eacb93e4747ee98374542036f42a9"}}, "title": "Nitric oxide dosed in short bursts at high concentrations may protect against Covid 19.", "authors": [{"family": "Hedenstierna", "given": "G\u00f6ran", "initials": "G"}, {"family": "Chen", "given": "Luni", "initials": "L"}, {"family": "Hedenstierna", "given": "Magnus", "initials": "M"}, {"family": "Lieberman", "given": "Robert", "initials": "R"}, {"family": "Fine", "given": "David H", "initials": "DH"}], "type": "journal article", "published": "2020-10-01", "journal": {"title": "Nitric Oxide", "issn": "1089-8611", "issn-l": "1089-8603", "volume": "103", "issue": null, "pages": "1-3"}, "abstract": "It has long been suggested that NO may inhibit an early stage in viral replication. Furthermore, in vitro tests have shown that NO inhibits the replication cycle of severe acute respiratory syndrome coronavirus. Despite smoking being listed as a risk factor to contract Covid-19, only a low proportion of the smokers suffered from SARS-corona infection in China 2003, and from Covid-19 in China, Europe and the US. We hypothesize, that the intermittent bursts of high NO concentration in cigarette smoke may be a mechanism in protecting against the virus. Mainstream smoke from cigarettes contains NO at peak concentrations of between about 250 ppm and 1350 ppm in each puff as compared to medicinal use of no more than 80 to a maximum of 160 ppm. The diffusion of NO through the cell wall to reach the virus should be significantly more effective at the very high NO concentration in the smoke, according to classic laws of physics. The only oxide of nitrogen in the mainstream smoke is NO, and the NO 2 concentration that is inhaled is very low or undetectable, and methemoglobin levels are lower in smokers than non-smokers, reasonably explained by the breaths of air in between the puffs that wash out the NO. Specialized iNO machines can now be developed to provide the drug intermittently in short bursts at high concentration dose, which would then provide both a preventative drug for those at high risk, as well as an effective treatment, without the health hazards associated with smoking.", "doi": "10.1016/j.niox.2020.06.005", "pmid": "32590117", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1089-8603(20)30161-0"}], "notes": [], "created": "2020-11-18T17:31:13.966Z", "modified": "2022-11-09T09:05:12.512Z"}, {"entity": "publication", "iuid": "8adbd429360c459896c97d05c262fe58", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8adbd429360c459896c97d05c262fe58.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8adbd429360c459896c97d05c262fe58"}}, "title": "Injuries From Asymptomatic COVID-19 Disease: New Hidden Toxicity Risk Factors in Thoracic Radiation Therapy.", "authors": [{"family": "Cella", "given": "Laura", "initials": "L"}, {"family": "Gagliardi", "given": "Giovanna", "initials": "G"}, {"family": "Hedman", "given": "Mattias", "initials": "M"}, {"family": "Palma", "given": "Giuseppe", "initials": "G"}], "type": "editorial", "published": "2020-10-01", "journal": {"title": "Int J Radiat Oncol Biol Phys", "issn": "1879-355X", "volume": "108", "issue": "2", "pages": "394-396", "issn-l": null}, "abstract": null, "doi": "10.1016/j.ijrobp.2020.06.055", "pmid": "32890518", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0360-3016(20)31342-0"}, {"db": "pmc", "key": "PMC7462877"}], "notes": [], "created": "2020-12-06T07:23:44.506Z", "modified": "2020-12-06T07:24:52.091Z"}, {"entity": "publication", "iuid": "e6a43c1c7bad40cc931b0b4b61b9ae1a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6a43c1c7bad40cc931b0b4b61b9ae1a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6a43c1c7bad40cc931b0b4b61b9ae1a"}}, "title": "In search of the relevant COVID research", "authors": [{"family": "Allebeck", "given": "Peter", "initials": "P", "orcid": "0000-0002-2778-6467", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de9f0e1c3e4d402b93e61ad1c5a771fb.json"}}, {"family": "S\u00f6rberg Wallin", "given": "Alma", "initials": "A", "orcid": "0000-0002-8804-095X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bdaa3ba8e9c149a6b4c05d924f31d0e5.json"}}], "type": "journal-article", "published": "2020-10-01", "journal": {"title": "Eur J Public Health", "issn": "1101-1262", "volume": "30", "issue": "5", "pages": "850-851", "issn-l": null}, "abstract": null, "doi": "10.1093/eurpub/ckaa169", "pmid": "32818271", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7536247"}, {"db": "pii", "key": "5894973"}], "notes": [], "created": "2020-12-07T12:24:48.738Z", "modified": "2023-06-19T07:32:18.110Z"}, {"entity": "publication", "iuid": "bf3c55cfd0094f7f84d20a9e3b1a934b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf3c55cfd0094f7f84d20a9e3b1a934b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf3c55cfd0094f7f84d20a9e3b1a934b"}}, "title": "Extracorporeal membrane oxygenation in children with COVID-19: Preliminary report from the collaborative EuroELSO prospective survey.", "authors": [{"family": "Di Nardo", "given": "M", "initials": "M"}, {"family": "Hoskote", "given": "A", "initials": "A"}, {"family": "Thiruchelvam", "given": "T", "initials": "T"}, {"family": "Lillie", "given": "J", "initials": "J"}, {"family": "Horan", "given": "M", "initials": "M"}, {"family": "Belda Hofheinz", "given": "S", "initials": "S"}, {"family": "Dupic", "given": "L", "initials": "L"}, {"family": "Gimeno", "given": "R", "initials": "R"}, {"family": "De Piero", "given": "M E", "initials": "ME"}, {"family": "Lo Coco", "given": "V", "initials": "V"}, {"family": "Roeleveld", "given": "P", "initials": "P"}, {"family": "Davidson", "given": "M", "initials": "M"}, {"family": "Jones", "given": "T", "initials": "T"}, {"family": "Broman", "given": "L M", "initials": "LM"}, {"family": "Lorusso", "given": "R", "initials": "R"}, {"family": "Belohlavek", "given": "J", "initials": "J"}, {"family": "EuroELSO Neonatal & Pediatric Working Group & collaborators on COVID-19", "given": "", "initials": ""}], "type": "journal article", "published": "2020-10-01", "journal": {"title": "ASAIO J", "issn": "1538-943X", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Perspective", "doi": "10.1097/MAT.0000000000001309", "pmid": "33009172", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-03T08:58:24.297Z", "modified": "2020-12-03T08:59:18.873Z"}, {"entity": "publication", "iuid": "87d2e0c1a45746429254b6b2c9d5c732", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87d2e0c1a45746429254b6b2c9d5c732.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87d2e0c1a45746429254b6b2c9d5c732"}}, "title": "Exploring views and experiences of how infections are detected and managed in practice by nurses, care workers and manager's in nursing homes in England and Sweden: a survey protocol.", "authors": [{"family": "Carey", "given": "N", "initials": "N"}, {"family": "Alkhamees", "given": "Nouf", "initials": "N"}, {"family": "Cox", "given": "Anna", "initials": "A"}, {"family": "Sund-Levander", "given": "Marta", "initials": "M"}, {"family": "Tingstr\u00f6m", "given": "Pia", "initials": "P"}, {"family": "Mold", "given": "Freda", "initials": "F"}], "type": "journal article", "published": "2020-10-01", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "10", "issue": "10", "pages": "e038390"}, "abstract": "In order to avoid unnecessary hospital admission and associated complications, there is an urgent need to improve the early detection of infection in nursing home residents. Monitoring signs and symptoms with checklists or aids called decision support tools may help nursing home staff to detect infection in residents, particularly during the current COVID-19 pandemic.We plan to conduct a survey exploring views and experiences of how infections are detected and managed in practice by nurses, care workers and managers in nursing homes in England and Sweden.\r\n\r\nAn international cross-sectional descriptive survey, using a pretested questionnaire, will be used to explore nurses, care workers and managers views and experiences of how infections are detected and managed in practice in nursing homes. Data will be analysed descriptively and univariate associations between personal and organisational factors explored. This will help identify important factors related to awareness, knowledge, attitudes, belief and skills likely to affect future implementation of a decision support tool for the early detection of infection in nursing home residents.\r\n\r\nThis study was approved using the self-certification process at the University of Surrey and Link\u00f6ping University ethics committee (Approval 2018/514-32) in 2018. Study findings will be disseminated through community/stakeholder/service user engagement events in each country, publication in academic peer-reviewed journals and conference presentations. A LAY summary will be provided to participants who indicate they would like to receive this information.This is the first stage of a plan of work to revise and evaluate the Early Detection of Infection Scale (EDIS) tool and its effect on managing infections and reducing unplanned hospital admissions in nursing home residents. Implementation of the EDIS tool may have important implications for the healthcare economy; this will be explored in cost-benefit analyses as the work progresses.", "doi": "10.1136/bmjopen-2020-038390", "pmid": "33004397", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-038390"}, {"db": "pmc", "key": "PMC7534694"}], "notes": [], "created": "2020-12-03T08:59:56.608Z", "modified": "2022-11-09T09:06:09.469Z"}, {"entity": "publication", "iuid": "41ec42fe6a674cf0bebd830f2d7ed408", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41ec42fe6a674cf0bebd830f2d7ed408.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41ec42fe6a674cf0bebd830f2d7ed408"}}, "title": "Early lessons from COVID-19 response and shifts in authority: public trust, policy legitimacy and political inclusion.", "authors": [{"family": "Bekker", "given": "Marleen", "initials": "M"}, {"family": "Ivankovic", "given": "Damir", "initials": "D"}, {"family": "Biermann", "given": "Olivia", "initials": "O"}], "type": "journal article", "published": "2020-10-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "volume": "30", "issue": "5", "pages": "854-855", "issn-l": "1101-1262"}, "abstract": null, "doi": "10.1093/eurpub/ckaa181", "pmid": "33020828", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "5918171"}, {"db": "pmc", "key": "PMC7665464"}], "notes": [], "created": "2020-12-01T18:17:21.351Z", "modified": "2020-12-01T18:17:45.967Z"}, {"entity": "publication", "iuid": "c8d295439f1242699d9db621b035dca5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c8d295439f1242699d9db621b035dca5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c8d295439f1242699d9db621b035dca5"}}, "title": "Coping behaviors associated with decreased anxiety and depressive symptoms during the COVID-19 pandemic and lockdown.", "authors": [{"family": "Fullana", "given": "Miquel A", "initials": "MA"}, {"family": "Hidalgo-Mazzei", "given": "Diego", "initials": "D"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}], "type": "letter", "published": "2020-10-01", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "issn-l": null, "volume": "275", "issue": null, "pages": "80-81"}, "abstract": "The COVID-19 pandemic and lockdown might increase anxiety and depressive symptoms, but some behaviors may protect against them.\r\n\r\nTo provide a preliminary evidence of the behaviors associated with decreased symptoms in the current COVID-19 pandemic and lockdown, we conducted a survey of 5545 adult individuals from the Spanish general population, two weeks after an official lockdown was established across the country.\r\n\r\nSixty-five percent of the sample reported anxiety or depressive symptoms. Following a healthy/balanced diet and not reading news/updates about COVID-19 very often were the best predictors of lower levels of anxiety symptoms. Following a healthy/balanced diet, following a routine, not reading news/updates about COVID-19 very often, taking the opportunity to pursue hobbies, and staying outdoors or looking outside were the best predictors of lower levels of depressive symptoms.\r\n\r\nCross-sectional nature and use of sample of convenience.\r\n\r\nThis study suggests that \"simple\" coping behaviors may protect against anxiety and depressive symptoms during the COVID-19 pandemic and lockdown.", "doi": "10.1016/j.jad.2020.06.027", "pmid": "32658829", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0165-0327(20)32385-5"}, {"db": "pmc", "key": "PMC7329680"}], "notes": [], "created": "2020-12-08T14:12:49.935Z", "modified": "2022-11-09T09:07:06.608Z"}, {"entity": "publication", "iuid": "39063093dd1344619fa982e652ac2867", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/39063093dd1344619fa982e652ac2867.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/39063093dd1344619fa982e652ac2867"}}, "title": "What will the long-lasting effect of the COVID-19 pandemic be on children's health and wellbeing?", "authors": [{"family": "Alfv\u00e9n", "given": "Tobias", "initials": "T"}], "type": "editorial", "published": "2020-10-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": "109", "issue": "10", "pages": "1924-1925"}, "abstract": "Editorial", "doi": "10.1111/apa.15513", "pmid": "32870545", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-07T07:48:22.434Z", "modified": "2020-12-07T07:48:47.205Z"}, {"entity": "publication", "iuid": "3110e37d5cb6405fa6a57bb42975d2ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3110e37d5cb6405fa6a57bb42975d2ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3110e37d5cb6405fa6a57bb42975d2ca"}}, "title": "What to expect for the influenza season 2020/21 with the ongoing COVID-19 pandemic in the World Health Organization European Region.", "authors": [{"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Pebody", "given": "Richard", "initials": "R"}], "type": "editorial", "published": "2020-10-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "25", "issue": "42", "pages": null}, "abstract": "Editorial", "doi": "10.2807/1560-7917.ES.2020.25.42.2001816", "pmid": "33094719", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7651872"}], "notes": [], "created": "2020-12-01T15:36:42.114Z", "modified": "2020-12-11T12:47:41.046Z"}, {"entity": "publication", "iuid": "abdab7a0dd85434b9d24eb8a689e7e6f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abdab7a0dd85434b9d24eb8a689e7e6f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abdab7a0dd85434b9d24eb8a689e7e6f"}}, "title": "Unraveling the Immune Response in Severe COVID-19", "authors": [{"family": "Rodriguez", "given": "Lucie", "initials": "L"}, {"family": "Brodin", "given": "Petter", "initials": "P"}], "type": "journal-article", "published": "2020-10-00", "journal": {"title": "J Clin Immunol", "issn": "0271-9142", "issn-l": null, "volume": "40", "issue": "7", "pages": "958-959"}, "abstract": "Comment", "doi": "10.1007/s10875-020-00849-9", "pmid": "32827284", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-04T15:15:07.666Z", "modified": "2021-01-11T10:50:50.121Z"}, {"entity": "publication", "iuid": "d15ae52217704044b6357eda9c434dbb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d15ae52217704044b6357eda9c434dbb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d15ae52217704044b6357eda9c434dbb"}}, "title": "Treating patients with cancer amidst the COVID-19 pandemic: experience of a regional hospital in the Piedmont region in northern Italy", "authors": [{"family": "Garrone", "given": "Ornella", "initials": "O"}, {"family": "Denaro", "given": "Nerina", "initials": "N"}, {"family": "Ruatta", "given": "Fiorella", "initials": "F"}, {"family": "Vanella", "given": "Paola", "initials": "P"}, {"family": "Granetto", "given": "Cristina", "initials": "C"}, {"family": "Vandone", "given": "Anna Maria", "initials": "AM"}, {"family": "Occelli", "given": "Marcella", "initials": "M"}, {"family": "Cauchi", "given": "Carolina", "initials": "C"}, {"family": "Ricci", "given": "Vincenzo", "initials": "V"}, {"family": "Fea", "given": "Elena", "initials": "E"}, {"family": "Di Costanzo", "given": "Gianna", "initials": "G"}, {"family": "Colantonio", "given": "Ida", "initials": "I"}, {"family": "Crosetto", "given": "Nicola", "initials": "N"}, {"family": "Merlano", "given": "Marco C", "initials": "MC"}], "type": "journal-article", "published": "2020-10-00", "journal": {"title": "Tumori", "issn": "0300-8916", "issn-l": null, "volume": "106", "issue": "5", "pages": "427-431"}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic is posing an unprecedented dilemma to oncologists worldwide, forcing them to decide whether to continue or suspend treatments in order to protect their most vulnerable patients from infection. After the first report from China, the outbreak spread rapidly worldwide. To, date no clear indications on how to treat patients with cancer with COVID-19 infection are available.\r\n\r\nWe report data on 21 patients with cancer referred to a single medical oncology unit of a general hospital from mid-March to April 23, 2020.\r\n\r\nNine patients were on active cancer therapy during the infection and all stopped medical treatments. Overall 8 patients developed pneumonia and 6 patients died of COVID-19.\r\n\r\nThe management of patients with cancer during the pandemic should be carefully balanced and discussed among oncologists and other key professionals involved in the treatment of this vulnerable group of patients, in order to balance the risk of treatment and the risk of infection.", "doi": "10.1177/0300891620942313", "pmid": "32703089", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Serology": null}, "xrefs": [], "notes": [], "created": "2020-11-04T16:12:10.666Z", "modified": "2021-02-26T08:46:49.391Z"}, {"entity": "publication", "iuid": "2e208a260070478a86af9d6ad8e3bcf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e208a260070478a86af9d6ad8e3bcf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e208a260070478a86af9d6ad8e3bcf3"}}, "title": "Tracking Potential COVID-19 Outbreaks With Influenzalike Symptoms Urgent Care Visits.", "authors": [{"family": "Muchmore", "given": "Brian", "initials": "B"}, {"family": "Muchmore", "given": "Patrick", "initials": "P"}, {"family": "Lee", "given": "Chi Wing", "initials": "CW"}, {"family": "Alarc\u00f3n-Riquelme", "given": "Marta E", "initials": "ME"}, {"family": "Muchmore", "given": "Andrew", "initials": "A"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Pediatrics", "issn": "1098-4275", "volume": "146", "issue": "4", "issn-l": null}, "abstract": null, "doi": "10.1542/peds.2020-1798", "pmid": "32699069", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "peds.2020-1798"}], "notes": [], "created": "2020-12-07T16:23:06.401Z", "modified": "2020-12-07T16:23:29.349Z"}, {"entity": "publication", "iuid": "e42a35963dbb42b3bf0375853434ff79", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e42a35963dbb42b3bf0375853434ff79.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e42a35963dbb42b3bf0375853434ff79"}}, "title": "The scope of mental health research during the COVID-19 pandemic and its aftermath.", "authors": [{"family": "Hotopf", "given": "Matthew", "initials": "M"}, {"family": "Bullmore", "given": "Ed", "initials": "E"}, {"family": "O'Connor", "given": "Rory C", "initials": "RC"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Br J Psychiatry", "issn": "1472-1465", "volume": "217", "issue": "4", "pages": "540-542", "issn-l": "0007-1250"}, "abstract": "The effects of the COVID-19 pandemic on population mental health are unknown. We need to understand the scale of any such impact in different sections of the population, who is most affected and how best to mitigate, prevent and treat any excess morbidity. We propose a coordinated and interdisciplinary mental health science response.", "doi": "10.1192/bjp.2020.125", "pmid": "32493516", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0007125020001257"}, {"db": "pmc", "key": "PMC7330278"}], "notes": [], "created": "2020-11-19T19:24:00.166Z", "modified": "2020-12-09T10:49:57.015Z"}, {"entity": "publication", "iuid": "57349b4780174ff1a804f9c0301aee0d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/57349b4780174ff1a804f9c0301aee0d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/57349b4780174ff1a804f9c0301aee0d"}}, "title": "The mediating effect of the cyberchondria and anxiety sensitivity in the association between problematic internet use, metacognition beliefs, and fear of COVID-19 among Iranian online population.", "authors": [{"family": "Seyed Hashemi", "given": "Seyed Ghasem", "initials": "SG"}, {"family": "Hosseinnezhad", "given": "Shalaleh", "initials": "S"}, {"family": "Dini", "given": "Solmaz", "initials": "S"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "issn-l": null, "volume": "6", "issue": "10", "pages": "e05135"}, "abstract": "With the rapid growth of the novel coronavirus disease 2019 (COVID-19), individuals may try to find related medical information using the internet to overcome their fears. Under such circumstances, individuals with the features of cyberchondria, anxiety sensitivity, and metacognitive beliefs in negative thoughts may suffer more fears than those without these features. Therefore, the present study proposed a model to understand the associations between problematic internet use (PIU), cyberchondria, anxiety sensitivity, metacognition beliefs, and fear of COVID-19. Utilizing a cross-sectional online survey, 651 Iranians completed the following psychometric scales: Metacognition Questionnaire-30 (MCQ-30), Anxiety Sensitivity Questionnaire (ASI), Cyberchondria Severity Scale-Short Form (CSS-12), Fear of COVID-19 Scale (FCV-19S), and Generalized Problematic Internet Use Scale (GPIUS). Structural equation modeling (SEM) was used to assess the proposed model via several fit indices. The indices include Tucker-Lewis index (TLI), comparative fit index (CFI), standardized root mean square residual (SRMR), and root mean square error of approximation (RMSEA). The fit indices (CFI = 0.948, TLI = 0.938, RMSEA = 0.053, and SRMR = 0.001) indicated the good fit between the data and the proposed model. Moreover, fear of COVID-19 was significantly and directly predicted by cyberchondria (\u03b2 = 0.479, p < .001) and anxiety sensitivity (\u03b2 = 0.286, p < .001). The relationship between PIU and cyberchondria with fear of COVID-19 was mediated significantly by anxiety sensitivity and metacognitive beliefs. Because fear of COVID-19 was found to be significantly associated with cyberchondria and anxiety sensitivity, healthcare providers may want to provide additional support for those with cyberchondria and anxiety sensitivity tendencies.", "doi": "10.1016/j.heliyon.2020.e05135", "pmid": "33072911", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(20)31978-2"}, {"db": "pmc", "key": "PMC7547399"}], "notes": [], "created": "2020-12-01T17:02:50.671Z", "modified": "2022-11-09T09:08:08.956Z"}, {"entity": "publication", "iuid": "53e0c79e38674500b109629509265e6e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53e0c79e38674500b109629509265e6e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53e0c79e38674500b109629509265e6e"}}, "title": "The impact of COVID-19 on research.", "authors": [{"family": "Harper", "given": "L", "initials": "L"}, {"family": "Kalfa", "given": "N", "initials": "N"}, {"family": "Beckers", "given": "G M A", "initials": "GMA"}, {"family": "Kaefer", "given": "M", "initials": "M"}, {"family": "Nieuwhof-Leppink", "given": "A J", "initials": "AJ"}, {"family": "Fossum", "given": "Magdalena", "initials": "M"}, {"family": "Herbst", "given": "K W", "initials": "KW"}, {"family": "Bagli", "given": "D", "initials": "D"}, {"family": "ESPU Research Committee", "given": "", "initials": ""}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "J Pediatr Urol", "issn": "1873-4898", "volume": "16", "issue": "5", "pages": "715-716", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jpurol.2020.07.002", "pmid": "32713792", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1477-5131(20)30412-5"}, {"db": "pmc", "key": "PMC7343645"}], "notes": [], "created": "2020-12-07T16:13:37.865Z", "modified": "2020-12-07T16:13:37.891Z"}, {"entity": "publication", "iuid": "00fdf422a3cd461bb84a16cfec56bc74", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/00fdf422a3cd461bb84a16cfec56bc74.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/00fdf422a3cd461bb84a16cfec56bc74"}}, "title": "The impact of COVID-19 on contraception and abortion care policy and practice: experiences from selected countries.", "authors": [{"family": "Bateson", "given": "Deborah J", "initials": "DJ"}, {"family": "Lohr", "given": "Patricia A", "initials": "PA"}, {"family": "Norman", "given": "Wendy V", "initials": "WV"}, {"family": "Moreau", "given": "Caroline", "initials": "C"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}, {"family": "Blumenthal", "given": "Paul D", "initials": "PD"}, {"family": "Hoggart", "given": "Lesley", "initials": "L"}, {"family": "Li", "given": "Hang-Wun Raymond", "initials": "HR"}, {"family": "Aiken", "given": "Abigail R A", "initials": "ARA"}, {"family": "Black", "given": "Kirsten I", "initials": "KI"}], "type": "editorial", "published": "2020-10-00", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-2009", "issn-l": "2515-1991", "volume": "46", "issue": "4", "pages": "241-243"}, "abstract": null, "doi": "10.1136/bmjsrh-2020-200709", "pmid": "32788180", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjsrh-2020-200709"}], "notes": [], "created": "2020-12-07T13:28:03.197Z", "modified": "2021-02-26T08:46:59.783Z"}, {"entity": "publication", "iuid": "772a3dbc1c954feda18fa8b7a7f68aaa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/772a3dbc1c954feda18fa8b7a7f68aaa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/772a3dbc1c954feda18fa8b7a7f68aaa"}}, "title": "The immuno-oncological challenge of COVID-19.", "authors": [{"family": "Derosa", "given": "Lisa", "initials": "L"}, {"family": "Melenotte", "given": "Cl\u00e9a", "initials": "C"}, {"family": "Griscelli", "given": "Franck", "initials": "F"}, {"family": "Gachot", "given": "Bertrand", "initials": "B"}, {"family": "Marabelle", "given": "Aur\u00e9lien", "initials": "A"}, {"family": "Kroemer", "given": "Guido", "initials": "G", "orcid": "0000-0002-9334-4405", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d17de2122d0429eaa48a733bf2ad28e.json"}}, {"family": "Zitvogel", "given": "Laurence", "initials": "L", "orcid": "0000-0003-1596-0998", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b10947c1a2b4884b3f502625a28c5e0.json"}}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Nat Cancer", "issn": "2662-1347", "volume": "1", "issue": "10", "pages": "946-964", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) and its causative virus, SARS-CoV-2, pose considerable challenges for the management of oncology patients. COVID-19 presents as a particularly severe respiratory and systemic infection in aging and immunosuppressed individuals, including patients with cancer. Moreover, severe COVID-19 is linked to an inflammatory burst and lymphopenia, which may aggravate cancer prognosis. Here we discuss why those with cancer are at higher risk of severe COVID-19, describe immune responses that confer protective or adverse reactions to this disease and indicate which antineoplastic therapies may either increase COVID-19 vulnerability or have a dual therapeutic effect on cancer and COVID-19.", "doi": "10.1038/s43018-020-00122-3", "pmid": "35121872", "labels": {"Type: Other": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s43018-020-00122-3"}], "notes": [], "created": "2023-01-13T13:38:05.320Z", "modified": "2023-01-13T13:38:05.345Z"}, {"entity": "publication", "iuid": "28cd389d36e14115adf57031c5a35ffe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/28cd389d36e14115adf57031c5a35ffe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/28cd389d36e14115adf57031c5a35ffe"}}, "title": "The Post COVID-19 Surgical Backlog: Now is the Time to Implement Enhanced Recovery After Surgery (ERAS).", "authors": [{"family": "Ljungqvist", "given": "Olle", "initials": "O"}, {"family": "Nelson", "given": "Gregg", "initials": "G"}, {"family": "Demartines", "given": "Nicolas", "initials": "N"}], "type": "editorial", "published": "2020-10-00", "journal": {"title": "World J Surg", "issn": "1432-2323", "volume": "44", "issue": "10", "pages": "3197-3198", "issn-l": null}, "abstract": null, "doi": "10.1007/s00268-020-05734-5", "pmid": "32803298", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00268-020-05734-5"}, {"db": "pmc", "key": "PMC7427753"}], "notes": [], "created": "2020-12-07T13:21:01.304Z", "modified": "2020-12-07T13:21:34.806Z"}, {"entity": "publication", "iuid": "6a70ee06a5b64d49858744269591ecf7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a70ee06a5b64d49858744269591ecf7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a70ee06a5b64d49858744269591ecf7"}}, "title": "Symptoms of a broken system: the gender gaps in COVID-19 decision-making.", "authors": [{"family": "van Daalen", "given": "Kim Robin", "initials": "KR"}, {"family": "Bajnoczki", "given": "Csongor", "initials": "C"}, {"family": "Chowdhury", "given": "Maisoon", "initials": "M"}, {"family": "Dada", "given": "Sara", "initials": "S"}, {"family": "Khorsand", "given": "Parnian", "initials": "P"}, {"family": "Socha", "given": "Anna", "initials": "A"}, {"family": "Lal", "given": "Arush", "initials": "A"}, {"family": "Jung", "given": "Laura", "initials": "L"}, {"family": "Alqodmani", "given": "Lujain", "initials": "L"}, {"family": "Torres", "given": "Irene", "initials": "I"}, {"family": "Ouedraogo", "given": "Samiratou", "initials": "S"}, {"family": "Mahmud", "given": "Amina Jama", "initials": "AJ"}, {"family": "Dhatt", "given": "Roopa", "initials": "R"}, {"family": "Phelan", "given": "Alexandra", "initials": "A"}, {"family": "Rajan", "given": "Dheepa", "initials": "D"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "5", "issue": "10", "pages": null, "issn-l": "2059-7908"}, "abstract": "Commentary", "doi": "10.1136/bmjgh-2020-003549", "pmid": "33004348", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-003549"}, {"db": "pmc", "key": "PMC7533958"}], "notes": [], "created": "2020-11-22T08:50:53.440Z", "modified": "2020-12-03T09:00:30.143Z"}, {"entity": "publication", "iuid": "3c717a035dbb4f3099e07a2a3beb9de5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3c717a035dbb4f3099e07a2a3beb9de5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3c717a035dbb4f3099e07a2a3beb9de5"}}, "title": "Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population.", "authors": [{"family": "Ciabattini", "given": "Annalisa", "initials": "A"}, {"family": "Garagnani", "given": "Paolo", "initials": "P"}, {"family": "Santoro", "given": "Francesco", "initials": "F"}, {"family": "Rappuoli", "given": "Rino", "initials": "R"}, {"family": "Franceschi", "given": "Claudio", "initials": "C"}, {"family": "Medaglini", "given": "Donata", "initials": "D"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Semin Immunopathol", "issn": "1863-2300", "volume": "42", "issue": "5", "pages": "619-634", "issn-l": "1863-2297"}, "abstract": "The SARS-CoV-2 pandemic urgently calls for the development of effective preventive tools. COVID-19 hits greatly the elder and more fragile fraction of the population boosting the evergreen issue of the vaccination of older people. The development of a vaccine against SARS-CoV-2 tailored for the elderly population faces the challenge of the poor immune responsiveness of the older population due to immunosenescence, comorbidities, and pharmacological treatments. Moreover, it is likely that the inflammaging phenotype associated with age could both influence vaccination efficacy and exacerbate the risk of COVID-19-related \"cytokine storm syndrome\" with an overlap between the factors which impact vaccination effectiveness and those that boost virulence and worsen the prognosis of SARS-CoV-2 infection. The complex and still unclear immunopathological mechanisms of SARS-CoV-2 infection, together with the progressive age-related decline of immune responses, and the lack of clear correlates of protection, make the design of vaccination strategies for older people extremely challenging. In the ongoing effort in vaccine development, different SARS-CoV-2 vaccine candidates have been developed, tested in pre-clinical and clinical studies and are undergoing clinical testing, but only a small fraction of these are currently being tested in the older fraction of the population. Recent advances in systems biology integrating clinical, immunologic, and omics data can help to identify stable and robust markers of vaccine response and move towards a better understanding of SARS-CoV-2 vaccine responses in the elderly.", "doi": "10.1007/s00281-020-00821-0", "pmid": "33159214", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00281-020-00821-0"}, {"db": "pmc", "key": "PMC7646713"}], "notes": [], "created": "2020-11-26T12:26:46.196Z", "modified": "2020-11-27T10:08:00.584Z"}, {"entity": "publication", "iuid": "0dec90693fd642e1a368638f5da7892b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0dec90693fd642e1a368638f5da7892b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0dec90693fd642e1a368638f5da7892b"}}, "title": "Risks, resilience, and pathways to sustainable aviation: A COVID-19 perspective.", "authors": [{"family": "G\u00f6ssling", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "J Air Transp Manag", "issn": "1873-2089", "volume": "89", "issue": null, "pages": "101933", "issn-l": null}, "abstract": "This paper discusses the COVID-19 pandemic as an opportunity to reconsider the foundations of the global aviation system. There is much evidence that air transport creates opportunities as well as risks. While the former accrue to businesses and individuals, risks are imposed on society. Pandemics, in which aviation has a role as a vector of pathogen distribution, as well as the sector's contribution to climate change are examples of long-standing negative externalities that continue to be ignored in assessments of aviation's economic performance and societal importance. As commercial aviation has shown limited economic resilience throughout its history, this short paper questions whether a return to business-as-usual, supported by very significant State aid payments, is desirable. The volume growth model championed by industry and aviation proponents may have to be replaced with an alternative model of a slimmed air transport system that is economically less vulnerable and accounting for its environmental impacts.", "doi": "10.1016/j.jairtraman.2020.101933", "pmid": "32952322", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0969-6997(20)30516-0"}, {"db": "pmc", "key": "PMC7492147"}], "notes": [], "created": "2020-12-03T09:33:48.678Z", "modified": "2020-12-03T09:33:48.703Z"}, {"entity": "publication", "iuid": "3fd62190ee1d459bbeb4b5f3eb01129c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3fd62190ee1d459bbeb4b5f3eb01129c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3fd62190ee1d459bbeb4b5f3eb01129c"}}, "title": "Returning to digestive endoscopy normality will be slow and must include novelty and telemedicine.", "authors": [{"family": "Koulaouzidis", "given": "Anastasios", "initials": "A"}, {"family": "Marlicz", "given": "Wojciech", "initials": "W"}, {"family": "Wenzek", "given": "Hagen", "initials": "H"}, {"family": "Koulaouzidis", "given": "George", "initials": "G"}, {"family": "Eliakim", "given": "Rami", "initials": "R"}, {"family": "Toth", "given": "Ervin", "initials": "E"}], "type": "letter", "published": "2020-10-00", "journal": {"title": "Dig Liver Dis", "issn": "1878-3562", "volume": "52", "issue": "10", "pages": "1099-1101", "issn-l": null}, "abstract": null, "doi": "10.1016/j.dld.2020.05.048", "pmid": "32571667", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1590-8658(20)30255-3"}, {"db": "pmc", "key": "PMC7304960"}], "notes": [], "created": "2020-12-08T16:28:21.367Z", "modified": "2020-12-08T16:28:21.390Z"}, {"entity": "publication", "iuid": "aace0e08aac84543b6d0633a82446ef2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aace0e08aac84543b6d0633a82446ef2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aace0e08aac84543b6d0633a82446ef2"}}, "title": "Pressure Optimized PowEred Respirator (PROPER): A miniaturized wearable cleanroom and biosafety system for aerially transmitted viral infections such as COVID-19.", "authors": [{"family": "Nazarious", "given": "Miracle Israel", "initials": "MI"}, {"family": "Mathanlal", "given": "Thasshwin", "initials": "T"}, {"family": "Zorzano", "given": "Maria-Paz", "initials": "MP"}, {"family": "Martin-Torres", "given": "Javier", "initials": "J"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "HardwareX", "issn": "2468-0672", "volume": "8", "issue": null, "pages": "e00144", "issn-l": null}, "abstract": "The supply of Personal Protective Equipment (PPE) in hospitals to keep the Health Care Professionals (HCP) safe taking care of patients may be limited, especially during the outbreak of a new disease. In particular, the face and body protective equipment is critical to prevent the wearer from exposure to pathogenic biological airborne particulates. This situation has been now observed worldwide during the onset of the COVID-19 pandemic. As concern over shortages of PPE at hospitals grows, we share with the public and makers' community the Pressure Optimized PowEred Respirator (PROPER) equipment, made out of COTS components. It is functionally equivalent to a Powered Air Purifying Respirator (PAPR). PROPER, a hood-based system which uses open source and easily accessible components is low-cost, relatively passive in terms of energy consumption and mechanisms, and easy and fast to 3D print, build and assemble. We have adapted our experience on building clean room environments and qualifying the bioburden of space instruments to this solution, which is in essence a miniaturized, personal, wearable cleanroom. PROPER would be able to offer better protection than an N95 respirator mask, mainly because it is insensitive to seal fit and it shields the eyes as well. The PROPER SMS fabric is designed for single-use and not intended for reuse, as they may start to tear and fail but the rest of the parts can be disinfected and reused. We provide a set of guidelines to build a low-cost 3D printed solution for an effective PAPR system and describe the procedures to validate it to comply with the biosafety level 3 requirements. We have validated the prototype of PROPER unit for air flow, ISO class cleanliness level, oxygen and carbon-dioxide gas concentrations during exhalation, and present here these results for illustration. We demonstrate that the area inside the hood is more than 200 times cleaner than the external ambient without the operator and more than 175 times with the operator and in an aerosol exposed environment. We also include the procedure to clean and disinfect the equipment for reuse. PROPER may be a useful addition to provide protection to HCPs against the SARS-CoV-2 virus or other potential future viral diseases that are transmitted aerially.", "doi": "10.1016/j.ohx.2020.e00144", "pmid": "33043172", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2468-0672(20)30053-5"}, {"db": "pmc", "key": "PMC7536593"}], "notes": [], "created": "2020-12-01T17:19:47.076Z", "modified": "2020-12-01T17:19:47.101Z"}, {"entity": "publication", "iuid": "7eac38cde76147eca0013d4c962fdd5e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7eac38cde76147eca0013d4c962fdd5e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7eac38cde76147eca0013d4c962fdd5e"}}, "title": "Physical activity during COVID-19 quarantine.", "authors": [{"family": "Shahidi", "given": "Seyed H", "initials": "SH"}, {"family": "Stewart Williams", "given": "Jennifer", "initials": "J"}, {"family": "Hassani", "given": "Fahimeh", "initials": "F"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": "109", "issue": "10", "pages": "2147-2148", "issn-l": "0803-5253"}, "abstract": null, "doi": "10.1111/apa.15420", "pmid": "32557827", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7323361"}], "notes": [], "created": "2020-12-09T07:45:52.698Z", "modified": "2020-12-09T07:46:00.446Z"}, {"entity": "publication", "iuid": "a6f02b3fa3814e92b4279055100a2c89", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6f02b3fa3814e92b4279055100a2c89.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6f02b3fa3814e92b4279055100a2c89"}}, "title": "Pediatric transplantation in Europe during the COVID-19 pandemic: Early impact on activity and healthcare.", "authors": [{"family": "Don\u00e1", "given": "Daniele", "initials": "D"}, {"family": "Torres Canizales", "given": "Juan", "initials": "J"}, {"family": "Benetti", "given": "Elisa", "initials": "E"}, {"family": "Cananzi", "given": "Mara", "initials": "M"}, {"family": "De Corti", "given": "Federica", "initials": "F"}, {"family": "Calore", "given": "Elisabetta", "initials": "E"}, {"family": "Hierro", "given": "Loreto", "initials": "L"}, {"family": "Ramos Boluda", "given": "Esther", "initials": "E"}, {"family": "Melgosa Hijosa", "given": "Marta", "initials": "M"}, {"family": "Garcia Guereta", "given": "Luis", "initials": "L"}, {"family": "P\u00e9rez Mart\u00ednez", "given": "Antonio", "initials": "A"}, {"family": "Barrios", "given": "Maribel", "initials": "M"}, {"family": "Costa Reis", "given": "Patricia", "initials": "P"}, {"family": "Teixeira", "given": "Ana", "initials": "A"}, {"family": "Lopes", "given": "Maria Francelina", "initials": "MF"}, {"family": "Kalici\u0144ski", "given": "Piotr", "initials": "P"}, {"family": "Branchereau", "given": "Sophie", "initials": "S"}, {"family": "Boyer", "given": "Olivia", "initials": "O"}, {"family": "Debray", "given": "Dominque", "initials": "D"}, {"family": "Sciveres", "given": "Marco", "initials": "M"}, {"family": "Wennberg", "given": "Lars", "initials": "L"}, {"family": "Fischler", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Barany", "given": "Peter", "initials": "P"}, {"family": "Baker", "given": "Alastair", "initials": "A"}, {"family": "Baumann", "given": "Ulrich", "initials": "U"}, {"family": "Schwerk", "given": "Nicolaus", "initials": "N"}, {"family": "Nicastro", "given": "Emanuele", "initials": "E"}, {"family": "Candusso", "given": "Manila", "initials": "M"}, {"family": "Toporski", "given": "Jacek", "initials": "J"}, {"family": "Sokal", "given": "Etienne", "initials": "E"}, {"family": "Stephenne", "given": "Xavier", "initials": "X"}, {"family": "Lindemans", "given": "Caroline", "initials": "C"}, {"family": "Miglinas", "given": "Marius", "initials": "M"}, {"family": "Rascon", "given": "Jelena", "initials": "J"}, {"family": "Jara", "given": "Paloma", "initials": "P"}, {"family": "ERN TransplantChild", "given": "", "initials": ""}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Clin Transplant", "issn": "1399-0012", "volume": "34", "issue": "10", "pages": "e14063", "issn-l": null}, "abstract": "The current pandemic SARS-CoV-2 has required an unusual allocation of resources that can negatively impact chronically ill patients and high-complexity procedures. Across the European Reference Network on Pediatric Transplantation (ERN TransplantChild), we conducted a survey to investigate the impact of the COVID-19 outbreak on pediatric transplant activity and healthcare practices in both solid organ transplantation (SOT) and hematopoietic stem cell transplantation (HSCT). The replies of 30 professionals from 18 centers in Europe were collected. Twelve of 18 centers (67%) showed a reduction in their usual transplant activity. Additionally, outpatient visits have been modified and restricted to selected ones, and the use of telemedicine tools has increased. Additionally, a total of 14 COVID-19 pediatric transplanted patients were identified at the time of the survey, including eight transplant recipients and six candidates for transplantation. Only two moderate-severe cases were reported, both in HSCT setting. These survey results demonstrate the limitations in healthcare resources for pediatric transplantation patients during early stages of this pandemic. COVID-19 disease is a major worldwide challenge for the field of pediatric transplantation, where there will be a need for systematic data collection, encouraging regular discussions to address the long-term consequences for pediatric transplantation candidates, recipients, and their families.", "doi": "10.1111/ctr.14063", "pmid": "32786120", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7435500"}], "notes": [], "created": "2020-12-07T13:28:32.289Z", "modified": "2020-12-07T13:28:32.314Z"}, {"entity": "publication", "iuid": "04e4c4b436a346d5aab70592cfa88caf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/04e4c4b436a346d5aab70592cfa88caf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/04e4c4b436a346d5aab70592cfa88caf"}}, "title": "Pathophysiology of the COVID-19 - entry to the CNS through the nose.", "authors": [{"family": "Ylikoski", "given": "Jukka", "initials": "J"}, {"family": "Markkanen", "given": "Marika", "initials": "M"}, {"family": "M\u00e4kitie", "given": "Antti", "initials": "A"}], "type": "editorial", "published": "2020-10-00", "journal": {"title": "Acta Otolaryngol", "issn": "1651-2251", "volume": "140", "issue": "10", "pages": "886-889", "issn-l": "0001-6489"}, "abstract": null, "doi": "10.1080/00016489.2020.1773533", "pmid": "32597276", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-26T12:25:16.279Z", "modified": "2020-11-30T08:54:52.911Z"}, {"entity": "publication", "iuid": "96b0715e8c8b4184a63d7666de8d709d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/96b0715e8c8b4184a63d7666de8d709d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/96b0715e8c8b4184a63d7666de8d709d"}}, "title": "Paediatric COVID-19 admissions in a region with open schools during the two first months of the pandemic.", "authors": [{"family": "Hildenwall", "given": "Helena", "initials": "H"}, {"family": "Luthander", "given": "Joachim", "initials": "J"}, {"family": "Rhedin", "given": "Samuel", "initials": "S"}, {"family": "Hertting", "given": "Olof", "initials": "O"}, {"family": "Olsson-\u00c5kefeldt", "given": "Selma", "initials": "S"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Alfv\u00e9n", "given": "Tobias", "initials": "T"}, {"family": "Herlenius", "given": "Eric", "initials": "E"}, {"family": "Ryd Rinder", "given": "Malin", "initials": "M"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": "109", "issue": "10", "pages": "2152-2154", "issn-l": "0803-5253"}, "abstract": null, "doi": "10.1111/apa.15432", "pmid": "32567145", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7323214"}], "notes": [], "created": "2020-12-08T16:30:28.877Z", "modified": "2021-02-26T08:45:48.478Z"}, {"entity": "publication", "iuid": "8a9af387c8834711aab4872a8c36a9e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a9af387c8834711aab4872a8c36a9e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a9af387c8834711aab4872a8c36a9e7"}}, "title": "Open synthesis and the coronavirus pandemic in 2020.", "authors": [{"family": "Haddaway", "given": "Neal R", "initials": "NR"}, {"family": "Akl", "given": "Elie A", "initials": "EA"}, {"family": "Page", "given": "Matthew J", "initials": "MJ"}, {"family": "Welch", "given": "Vivian A", "initials": "VA"}, {"family": "Keenan", "given": "Ciara", "initials": "C"}, {"family": "Lotfi", "given": "Tamara", "initials": "T"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "J Clin Epidemiol", "issn": "1878-5921", "volume": "126", "issue": null, "pages": "184-191", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jclinepi.2020.06.032", "pmid": "32621854", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0895-4356(20)30461-3"}, {"db": "pmc", "key": "PMC7328560"}], "notes": [], "created": "2020-11-30T08:51:27.807Z", "modified": "2020-11-30T08:51:27.832Z"}, {"entity": "publication", "iuid": "c416ec4ee19a4167910ae1f8f02cc9a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c416ec4ee19a4167910ae1f8f02cc9a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c416ec4ee19a4167910ae1f8f02cc9a6"}}, "title": "No small matter: a perspective on nanotechnology-enabled solutions to fight COVID-19.", "authors": [{"family": "Jones", "given": "Georgia Wilson", "initials": "GW"}, {"family": "Monopoli", "given": "Marco P", "initials": "MP"}, {"family": "Campagnolo", "given": "Luisa", "initials": "L"}, {"family": "Pietroiusti", "given": "Antonio", "initials": "A"}, {"family": "Tran", "given": "Lang", "initials": "L"}, {"family": "Fadeel", "given": "Bengt", "initials": "B"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Nanomedicine (Lond)", "issn": "1748-6963", "volume": "15", "issue": "24", "pages": "2411-2427", "issn-l": null}, "abstract": "There is an urgent need for safe and effective approaches to combat COVID-19. Here, we asked whether lessons learned from nanotoxicology and nanomedicine could shed light on the current pandemic. SARS-CoV-2, the causative agent, may trigger a mild, self-limiting disease with respiratory symptoms, but patients may also succumb to a life-threatening systemic disease. The host response to the virus is equally complex and studies are now beginning to unravel the immunological correlates of COVID-19. Nanotechnology can be applied for the delivery of antiviral drugs or other repurposed drugs. Moreover, recent work has shown that synthetic nanoparticles wrapped with host-derived cellular membranes may prevent virus infection. We posit that nanoparticles decorated with ACE2, the receptor for SARS-CoV-2, could be exploited as decoys to intercept the virus before it infects cells in the respiratory tract. However, close attention should be paid to biocompatibility before such nano-decoys are deployed in the clinic.", "doi": "10.2217/nnm-2020-0286", "pmid": "32873192", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7488724"}], "notes": [], "created": "2020-12-06T07:36:25.377Z", "modified": "2020-12-06T07:36:25.402Z"}, {"entity": "publication", "iuid": "59b00923374e47adbc0f1d94c7e13e40", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/59b00923374e47adbc0f1d94c7e13e40.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/59b00923374e47adbc0f1d94c7e13e40"}}, "title": "Neurological manifestations of coronavirus infections - a systematic review.", "authors": [{"family": "Almqvist", "given": "Jesper", "initials": "J"}, {"family": "Granberg", "given": "Tobias", "initials": "T"}, {"family": "Tzortzakakis", "given": "Antonios", "initials": "A"}, {"family": "Klironomos", "given": "Stefanos", "initials": "S"}, {"family": "Kollia", "given": "Evangelia", "initials": "E"}, {"family": "\u00d6hberg", "given": "Claes", "initials": "C"}, {"family": "Martin", "given": "Roland", "initials": "R"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Ouellette", "given": "Russell", "initials": "R"}, {"family": "Ineichen", "given": "Benjamin V", "initials": "BV"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Ann Clin Transl Neurol", "issn": "2328-9503", "volume": "7", "issue": "10", "pages": "2057-2071", "issn-l": "2328-9503"}, "abstract": "To optimize diagnostic workup of the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, we systematically reviewed neurological and neuroradiological manifestations of SARS-CoV-2 and all other known human coronavirus species (HCoV). Which lessons can we learn? We identified relevant publications (until 26 July 2020) using systematic searches in PubMed, Web of Science, and Ovid EMBASE with predefined search strings. A total of 4571 unique publications were retrieved, out of which 378 publications were selected for in-depth analysis by two raters, including a total of 17549 (out of which were 14418 SARS-CoV-2) patients. Neurological complications and associated neuroradiological manifestations are prevalent for all HCoVs (HCoV-229E, HKU1, NL63, OC43, Middle East respiratory syndrome (MERS)-CoV, SARS-CoV-1, and SARS-CoV-2). Moreover there are similarities in symptomatology across different HCoVs, particularly between SARS-CoV-1 and SARS-CoV-2. Common neurological manifestations include fatigue, headache, and smell/taste disorders. Additionally, clinicians need to be attentive for at least five classes of neurological complications: (1) Cerebrovascular disorders including ischemic stroke and macro/micro-hemorrhages, (2) encephalopathies, (3) para-/postinfectious immune-mediated complications such as Guillain-Barr\u00e9 syndrome and acute disseminated encephalomyelitis, (4) (meningo-)encephalitis, potentially with concomitant seizures, and (5) neuropsychiatric complications such as psychosis and mood disorders. Our systematic review highlights the need for vigilance regarding neurological complications in patients infected by SARS-CoV-2 and other HCoVs, especially since some complications may result in chronic disability. Neuroimaging protocols should be designed to specifically screen for these complications. Therefore, we propose practical imaging guidelines to facilitate the diagnostic workup and monitoring of patients infected with HCoVs.", "doi": "10.1002/acn3.51166", "pmid": "32853453", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7461163"}], "notes": [], "created": "2020-11-26T12:17:30.281Z", "modified": "2020-11-30T08:36:35.331Z"}, {"entity": "publication", "iuid": "442c80b494834398a3e3d3882c5ea990", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/442c80b494834398a3e3d3882c5ea990.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/442c80b494834398a3e3d3882c5ea990"}}, "title": "Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia (COVID STEROID) trial-Protocol and statistical analysis plan.", "authors": [{"family": "Petersen", "given": "Marie Warrer", "initials": "MW"}, {"family": "Meyhoff", "given": "Tine Sylvest", "initials": "TS"}, {"family": "Helleberg", "given": "Marie", "initials": "M"}, {"family": "Kjaer", "given": "Maj-Brit N\u00f8rregaard", "initials": "MN"}, {"family": "Granholm", "given": "Anders", "initials": "A"}, {"family": "Hjorts\u00f8", "given": "Carl Johan Steensen", "initials": "CJS"}, {"family": "Jensen", "given": "Thomas Steen", "initials": "TS"}, {"family": "M\u00f8ller", "given": "Morten Hylander", "initials": "MH"}, {"family": "Hjortrup", "given": "Peter Buhl", "initials": "PB"}, {"family": "Wetterslev", "given": "Mik", "initials": "M"}, {"family": "Vesterlund", "given": "Gitte Kingo", "initials": "GK"}, {"family": "Russell", "given": "Lene", "initials": "L"}, {"family": "J\u00f8rgensen", "given": "Vibeke Lind", "initials": "VL"}, {"family": "Tjelle", "given": "Klaus", "initials": "K"}, {"family": "Benfield", "given": "Thomas", "initials": "T"}, {"family": "Ulrik", "given": "Charlotte Suppli", "initials": "CS"}, {"family": "Andreasen", "given": "Anne Sofie", "initials": "AS"}, {"family": "Mohr", "given": "Thomas", "initials": "T"}, {"family": "Bestle", "given": "Morten H", "initials": "MH"}, {"family": "Poulsen", "given": "Lone Musaeus", "initials": "LM"}, {"family": "Hitz", "given": "Mette Friberg", "initials": "MF"}, {"family": "Hildebrandt", "given": "Thomas", "initials": "T"}, {"family": "Knudsen", "given": "Lene Surland", "initials": "LS"}, {"family": "M\u00f8ller", "given": "Anders", "initials": "A"}, {"family": "S\u00f8lling", "given": "Christoffer Grant", "initials": "CG"}, {"family": "Br\u00f8chner", "given": "Anne Craveiro", "initials": "AC"}, {"family": "Rasmussen", "given": "Bodil Steen", "initials": "BS"}, {"family": "Nielsen", "given": "Henrik", "initials": "H"}, {"family": "Christensen", "given": "Steffen", "initials": "S"}, {"family": "Str\u00f8m", "given": "Thomas", "initials": "T"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Wahlin", "given": "Rebecka Rubenson", "initials": "RR"}, {"family": "Jakob", "given": "Stephan", "initials": "S"}, {"family": "Cioccari", "given": "Luca", "initials": "L"}, {"family": "Venkatesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Hammond", "given": "Naomi", "initials": "N"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Myatra", "given": "Sheila Nainan", "initials": "SN"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Lange", "given": "Theis", "initials": "T"}, {"family": "Perner", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "volume": "64", "issue": "9", "pages": "1365-1375", "issn-l": "0001-5172"}, "abstract": "Severe acute respiratory syndrome coronavirus-2 has caused a pandemic of coronavirus disease (COVID-19) with many patients developing hypoxic respiratory failure. Corticosteroids reduce the time on mechanical ventilation, length of stay in the intensive care unit and potentially also mortality in similar patient populations. However, corticosteroids have undesirable effects, including longer time to viral clearance. Clinical equipoise on the use of corticosteroids for COVID-19 exists.\n\nThe COVID STEROID trial is an international, randomised, stratified, blinded clinical trial. We will allocate 1000 adult patients with COVID-19 receiving \u226510 L/min of oxygen or on mechanical ventilation to intravenous hydrocortisone 200 mg daily vs placebo (0.9% saline) for 7 days. The primary outcome is days alive without life support (ie mechanical ventilation, circulatory support, and renal replacement therapy) at day 28. Secondary outcomes are serious adverse reactions at day 14; days alive without life support at day 90; days alive and out of hospital at day 90; all-cause mortality at day 28, day 90, and 1 year; and health-related quality of life at 1 year. We will conduct the statistical analyses according to this protocol, including interim analyses for every 250 patients followed for 28 days. The primary outcome will be compared using the Kryger Jensen and Lange test in the intention to treat population and reported as differences in means and medians with 95% confidence intervals.\n\nThe COVID STEROID trial will provide important evidence to guide the use of corticosteroids in COVID-19 and severe hypoxia.", "doi": "10.1111/aas.13673", "pmid": "32779728", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7404666"}], "notes": [], "created": "2020-12-07T13:32:20.495Z", "modified": "2021-02-26T08:45:48.099Z"}, {"entity": "publication", "iuid": "b1323021dc7d45f6b4afca061534617c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1323021dc7d45f6b4afca061534617c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1323021dc7d45f6b4afca061534617c"}}, "title": "Long-term consequences of COVID-19: research needs.", "authors": [{"family": "Yelin", "given": "Dana", "initials": "D"}, {"family": "Wirtheim", "given": "Eytan", "initials": "E"}, {"family": "Vetter", "given": "Pauline", "initials": "P"}, {"family": "Kalil", "given": "Andre C", "initials": "AC"}, {"family": "Bruchfeld", "given": "Judith", "initials": "J"}, {"family": "Runold", "given": "Michael", "initials": "M"}, {"family": "Guaraldi", "given": "Giovanni", "initials": "G"}, {"family": "Mussini", "given": "Cristina", "initials": "C"}, {"family": "Gudiol", "given": "Carlota", "initials": "C"}, {"family": "Pujol", "given": "Miquel", "initials": "M"}, {"family": "Bandera", "given": "Alessandra", "initials": "A"}, {"family": "Scudeller", "given": "Luigia", "initials": "L"}, {"family": "Paul", "given": "Mical", "initials": "M"}, {"family": "Kaiser", "given": "Laurent", "initials": "L"}, {"family": "Leibovici", "given": "Leonard", "initials": "L"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "volume": "20", "issue": "10", "pages": "1115-1117", "issn-l": null}, "abstract": null, "doi": "10.1016/S1473-3099(20)30701-5", "pmid": "32888409", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(20)30701-5"}, {"db": "pmc", "key": "PMC7462626"}], "notes": [], "created": "2020-12-06T07:25:57.455Z", "modified": "2020-12-06T07:26:37.438Z"}, {"entity": "publication", "iuid": "15e7e3fed3654797aae82e30150d72d6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15e7e3fed3654797aae82e30150d72d6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15e7e3fed3654797aae82e30150d72d6"}}, "title": "Laser irradiated phenothiazines: New potential treatment for COVID-19 explored by molecular docking.", "authors": [{"family": "Udrea", "given": "Ana-Maria", "initials": "AM"}, {"family": "Avram", "given": "Speranta", "initials": "S"}, {"family": "Nistorescu", "given": "Simona", "initials": "S"}, {"family": "Pascu", "given": "Mihail-Lucian", "initials": "ML"}, {"family": "Romanitan", "given": "Mihaela Oana", "initials": "MO"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "J Photochem Photobiol B", "issn": "1873-2682", "volume": "211", "issue": null, "pages": "111997", "issn-l": null}, "abstract": "The worldwide infection with the new Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) demands urgently new potent treatment(s). In this study we predict, using molecular docking, the binding affinity of 15 phenothiazines (antihistaminic and antipsychotic drugs) when interacting with the main protease (M pro) of SARS-CoV-2. Additionally, we tested the binding affinity of photoproducts identified after irradiation of phenothiazines with Nd:YAG laser beam at 266 nm respectively 355 nm. Our results reveal that thioridazine and its identified photoproducts (mesoridazine and sulforidazine) have high biological activity on the virus Mpro. This shows that thioridazine and its two photoproducts might represent new potent medicines to be used for treatment in this outbreak. Such results recommend these medicines for further tests on cell cultures infected with SARS-CoV-2 or animal model. The transition to human subjects of the suggested treatment will be smooth due to the fact that the drugs are already available on the market.", "doi": "10.1016/j.jphotobiol.2020.111997", "pmid": "32829256", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S1011-1344(20)30447-4"}, {"db": "pmc", "key": "PMC7428740"}], "notes": [], "created": "2020-12-07T11:46:08.690Z", "modified": "2021-02-26T08:45:02.860Z"}, {"entity": "publication", "iuid": "b630793a5e87457eaa2ed82dc2b65c38", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b630793a5e87457eaa2ed82dc2b65c38.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b630793a5e87457eaa2ed82dc2b65c38"}}, "title": "Is COVID-19 associated thrombosis caused by overactivation of the complement cascade? A literature review.", "authors": [{"family": "Fletcher-Sandersj\u00f6\u00f6", "given": "Alexander", "initials": "A"}, {"family": "Bellander", "given": "Bo-Michael", "initials": "BM"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Thromb Res", "issn": "1879-2472", "volume": "194", "issue": null, "pages": "36-41", "issn-l": "0049-3848"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 is responsible for the current COVID-19 pandemic resulting in an escalating number of cases and fatalities worldwide. Preliminary evidence from these patients, as well as past coronavirus epidemics, indicates that those infected suffer from disproportionate complement activation as well as excessive coagulation, leading to thrombotic complications and poor outcome. In non-coronavirus cohorts, evidence has accumulated of an interaction between the complement and coagulation systems, with one amplifying activation of the other. A pressing question is therefore if COVID-19 associated thrombosis could be caused by overactivation of the complement cascade? In this review, we summarize the literature on thrombotic complications in COVID-19, complement activation in coronavirus infections, and the crosstalk between the complement and coagulation systems. We demonstrate how the complement system is able to activate the coagulation cascade and platelets, inhibit fibrinolysis and stimulate endothelial cells. We also describe how these interactions see clinical relevance in several disorders where overactive complement results in a prothrombotic clinical presentation, and how it could be clinically relevant in COVID-19.", "doi": "10.1016/j.thromres.2020.06.027", "pmid": "32569879", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0049-3848(20)30269-3"}, {"db": "pmc", "key": "PMC7301826"}], "notes": [], "created": "2020-11-26T12:14:19.289Z", "modified": "2020-11-30T08:59:18.013Z"}, {"entity": "publication", "iuid": "6ac2ef0d1f96420ba6da209a41beff4b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ac2ef0d1f96420ba6da209a41beff4b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ac2ef0d1f96420ba6da209a41beff4b"}}, "title": "Invasive mechanical ventilation in a former preterm infant with COVID-19.", "authors": [{"family": "Nyholm", "given": "Silvia", "initials": "S"}, {"family": "Edner", "given": "Ann", "initials": "A"}, {"family": "Myrelid", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Janols", "given": "Helena", "initials": "H"}, {"family": "D\u00f6renberg", "given": "Rainer", "initials": "R"}, {"family": "Diderholm", "given": "Barbro", "initials": "B"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": "109", "issue": "10", "pages": "2141-2143", "issn-l": "0803-5253"}, "abstract": null, "doi": "10.1111/apa.15437", "pmid": "32569422", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7361564"}], "notes": [], "created": "2020-12-08T16:28:27.718Z", "modified": "2020-12-08T16:28:27.730Z"}, {"entity": "publication", "iuid": "6ebda7bd436a47428776a6a0d65f6831", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ebda7bd436a47428776a6a0d65f6831.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ebda7bd436a47428776a6a0d65f6831"}}, "title": "Interventions to Reduce Aerosolized Microbes in Dental Practice: A Systematic Review with Network Meta-analysis of Randomized Controlled Trials.", "authors": [{"family": "Koletsi", "given": "D", "initials": "D"}, {"family": "Belibasakis", "given": "G N", "initials": "GN"}, {"family": "Eliades", "given": "T", "initials": "T"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "J Dent Res", "issn": "1544-0591", "volume": "99", "issue": "11", "pages": "1228-1238", "issn-l": "0022-0345"}, "abstract": "The aim of this systematic review and network meta-analysis was to identify and rank the effectiveness of different interventions used in dental practice to reduce microbial load in aerosolized compounds. Seven electronic databases were searched to April 6, 2020, for randomized controlled trials (RCTs) or nonrandomized prospective studies in the field. Study selection, data extraction, and risk-of-bias assessment were performed for all included studies, while the outcome of interest pertained to differences in bacterial load quantification through the use of different interventions prior to aerosol-generating procedures in dental practices. Random effects frequentist network meta-analysis was performed, with mean difference (MD) and 95% CI as the effect measure. Confidence in the documented evidence was assessed through the newly fueled CINeMA framework (Confidence in Network Meta-analysis) based on the GRADE approach (Grading of Recommendations, Assessment, Development and Evaluation). Twenty-nine clinical trials were deemed eligible, 21 RCTs and 8 nonrandomized studies, while 11 RCTs contributed to the network meta-analysis, comprising 10 competing interventions. Tempered chlorhexidine (CHX) 0.2% as compared with nonactive control mouth rinse, prior to routine ultrasonic scaling, was most effective toward reduced postprocedural bacterial load with an MD of -0.92 (95% CI, -1.54 to -0.29) in log 10 bacterial CFUs (colony-forming units). For CHX 0.2%, an MD of -0.74 (95% CI, -1.07 to -0.40) was observed as compared with control. Tempered CHX 0.2% presented the highest probabilities of being ranked the most effective treatment (31.2%). Level of confidence varied from very low to moderate across all formulated comparisons. These findings summarize the current state of research evidence in the field of aerosolized bacteria in dentistry. Instigated by the era of SARS-CoV-2 pandemic, the stipulation of a broader evaluation of the aerosolized microbes, including viruses, potentially coupled with disinfectant-based prevention schemes should be prioritized.", "doi": "10.1177/0022034520943574", "pmid": "32660314", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-26T12:20:02.782Z", "modified": "2020-11-30T08:51:23.085Z"}, {"entity": "publication", "iuid": "8043a8d98fa242cfa5e92cf1d93b58b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8043a8d98fa242cfa5e92cf1d93b58b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8043a8d98fa242cfa5e92cf1d93b58b2"}}, "title": "Increasing maternal mortality associated with COVID-19 and shortage of intensive care is a serious concern in low-resource settings.", "authors": [{"family": "Silveira Campos", "given": "Luciana", "initials": "L"}, {"family": "Peixoto Caldas", "given": "Jos\u00e9 M", "initials": "JM"}], "type": "letter", "published": "2020-10-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "10", "pages": "1421", "issn-l": "0001-6349"}, "abstract": null, "doi": "10.1111/aogs.13975", "pmid": "32799338", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7461434"}], "notes": [], "created": "2020-12-07T13:22:08.337Z", "modified": "2020-12-07T13:22:08.347Z"}, {"entity": "publication", "iuid": "3c78deda48504db9a8f995bd38917104", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3c78deda48504db9a8f995bd38917104.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3c78deda48504db9a8f995bd38917104"}}, "title": "In silico Potential of Approved Antimalarial Drugs for Repurposing Against COVID-19.", "authors": [{"family": "Sachdeva", "given": "Cheryl", "initials": "C"}, {"family": "Wadhwa", "given": "Anju", "initials": "A"}, {"family": "Kumari", "given": "Anita", "initials": "A"}, {"family": "Hussain", "given": "Firasat", "initials": "F"}, {"family": "Jha", "given": "Preeti", "initials": "P"}, {"family": "Kaushik", "given": "Naveen K", "initials": "NK"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "OMICS", "issn": "1557-8100", "volume": "24", "issue": "10", "pages": "568-580", "issn-l": "1536-2310"}, "abstract": "Although the coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is wreaking havoc and resulting in mortality and morbidity across the planet, novel treatments are urgently needed. Drug repurposing offers an innovative approach in this context. We report here new findings on the in silico potential of several antimalarial drugs for repurposing against COVID-19. We conducted analyses by docking the compounds against two SARS-CoV-2-specific targets: (1) the receptor binding domain spike protein and (2) the main protease of the virus (MPro) using the Schr\u00f6dinger software. Importantly, the docking analysis revealed that doxycycline (DOX) showed the most effective binding to the spike protein of SARS-CoV-2, whereas halofantrine and mefloquine bound effectively with the main protease among the antimalarial drugs evaluated in the present study. The in silico approach reported here suggested that DOX could potentially be a good candidate for repurposing for COVID-19. In contrast, to decipher the actual potential of DOX and halofantrine against COVID-19, further in vitro and in vivo studies are called for. Drug repurposing warrants consideration as a viable research and innovation avenue as planetary health efforts to fight the COVID-19 continue.", "doi": "10.1089/omi.2020.0071", "pmid": "32757981", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2020-11-19T14:41:00.439Z", "modified": "2021-02-26T08:45:02.956Z"}, {"entity": "publication", "iuid": "ee6cb4249076448a8c69ea2732de3566", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee6cb4249076448a8c69ea2732de3566.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee6cb4249076448a8c69ea2732de3566"}}, "title": "High excess mortality in areas with young and socially vulnerable populations during the COVID-19 outbreak in Stockholm Region, Sweden.", "authors": [{"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A", "orcid": "0000-0001-9064-9222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/166407b0da5346b3aef841949b0212da.json"}}, {"family": "Vetrano", "given": "Davide L", "initials": "DL"}, {"family": "Rizzuto", "given": "Debora", "initials": "D"}, {"family": "Bellander", "given": "Tom", "initials": "T"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Dekhtyar", "given": "Serhiy", "initials": "S"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "issn-l": "2059-7908", "volume": "5", "issue": "10", "pages": "e003595"}, "abstract": "We aimed to describe the distribution of excess mortality (EM) during the first weeks of the COVID-19 outbreak in the Stockholm Region, Sweden, according to age, sex and sociodemographic context.\n\nWeekly all-cause mortality data were obtained from Statistics Sweden for the period 1 January 2015 to 17 May 2020. EM during the first 20 weeks of 2020 was estimated by comparing observed mortality rates with expected mortality rates during the five previous years (N=2 379 792). EM variation by socioeconomic status (tertiles of income, education, Swedish-born, gainful employment) and age distribution (share of 70+-year-old persons) was explored based on Demographic Statistics Area (DeSO) data.\n\nEM was first detected during the week of 23-29 March 2020. During the peak week of the epidemic (6-12 April 2020), an EM of 150% was observed (152% in 80+-year-old women; 183% in 80+-year-old men). During the same week, the highest EM was observed for DeSOs with lowest income (171%), lowest education (162%), lowest share of Swedish-born (178%) and lowest share of gainfully employed residents (174%). EM was further increased in areas with higher versus lower proportion of younger people (magnitude of increase: 1.2-1.7 times depending on socioeconomic measure).\n\nLiving in areas characterised by lower socioeconomic status and younger populations was linked to excess mortality during the COVID-19 pandemic in the Stockholm Region. These conditions might have facilitated viral spread. Our findings highlight the well-documented vulnerability linked to increasing age and sociodemographic context for COVID-19-related death.", "doi": "10.1136/bmjgh-2020-003595", "pmid": "33109636", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7592025"}, {"db": "pii", "key": "bmjgh-2020-003595"}], "notes": [], "created": "2020-11-27T10:24:44.096Z", "modified": "2023-06-19T15:28:44.800Z"}, {"entity": "publication", "iuid": "e4d57f90525b4263818c08975dabc530", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e4d57f90525b4263818c08975dabc530.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e4d57f90525b4263818c08975dabc530"}}, "title": "Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes.", "authors": [{"family": "Robinson", "given": "Emma L", "initials": "EL"}, {"family": "Alkass", "given": "Kanar", "initials": "K"}, {"family": "Bergmann", "given": "Olaf", "initials": "O"}, {"family": "Maguire", "given": "Janet J", "initials": "JJ"}, {"family": "Roderick", "given": "H Llewelyn", "initials": "HL"}, {"family": "Davenport", "given": "Anthony P", "initials": "AP"}], "type": "letter", "published": "2020-10-00", "journal": {"title": "J Mol Cell Cardiol", "issn": "1095-8584", "volume": "147", "issue": null, "pages": "88-91", "issn-l": null}, "abstract": null, "doi": "10.1016/j.yjmcc.2020.08.009", "pmid": "32818486", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0022-2828(20)30257-1"}, {"db": "pmc", "key": "PMC7431326"}], "notes": [], "created": "2020-12-07T12:24:07.369Z", "modified": "2021-02-26T08:45:48.812Z"}, {"entity": "publication", "iuid": "1d34fda32e3344aca9277e9b656cbcb2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d34fda32e3344aca9277e9b656cbcb2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d34fda32e3344aca9277e9b656cbcb2"}}, "title": "Future liasing of the lockdown during COVID-19 pandemic: The dawn is expected at hand from the darkest hour.", "authors": [{"family": "Khursheed", "given": "Anwar", "initials": "A"}, {"family": "Alam", "given": "Shamshad", "initials": "S"}, {"family": "Tyagi", "given": "Vinay Kumar", "initials": "VK"}, {"family": "Nagpure", "given": "Ajay S", "initials": "AS"}, {"family": "Khan", "given": "Abid Ali", "initials": "AA"}, {"family": "Gaur", "given": "Rubia Z", "initials": "RZ"}, {"family": "Singh", "given": "Sanyogita", "initials": "S"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Mukherjee", "given": "Santanu", "initials": "S"}, {"family": "Kumar", "given": "Manish", "initials": "M"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Groundw Sustain Dev", "issn": "2352-801X", "volume": "11", "issue": null, "pages": "100433", "issn-l": null}, "abstract": "The lockdown during COVID-19 pandemic has converted the world into new experimental laboratories, which may reveal temporal or spatial comparative analysis data. However, some startling information is gathered in terms of reduced premature mortality cases associated with air and water quality improvement, enhanced e-learning on a broader platform, work from home, and successful e-health. The decline in vehicular density on roads and congestion leads to reduced energy consumption and associated greenhouse gases (GHG) and other pollutants emission. The lockdown has also been identified as a possible emergency measure to combat severe air pollution episodes. Similarly, industrial pollution has been recognized as one of the primary causes of water resource pollution and would, therefore, bring change in policy vis-\u00e0-vis groundwater pollution control. Our findings suggest that the results of successful e-learning and work from home would be a permanent shift from conventional modes in the near future due to a drastic reduction in socio-economic cost. Our critical analysis also highlights that with such temporary lockdown measures acute/chronic ill-effects of anthropogenic perturbations on planet earth can be effectively estimated through sociocultural, socioeconomical and socio-political/sociotechnological nexus.", "doi": "10.1016/j.gsd.2020.100433", "pmid": "32835071", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2352-801X(20)30268-X"}, {"db": "pii", "key": "100433"}, {"db": "pmc", "key": "PMC7319642"}], "notes": [], "created": "2020-12-07T11:44:03.369Z", "modified": "2020-12-07T11:44:03.393Z"}, {"entity": "publication", "iuid": "ce1eb385f7aa43f881128314a8d2ae21", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ce1eb385f7aa43f881128314a8d2ae21.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ce1eb385f7aa43f881128314a8d2ae21"}}, "title": "Forgotten Technology in the COVID-19 Pandemic: Filtration Properties of Cloth and Cloth Masks-A Narrative Review.", "authors": [{"family": "Clase", "given": "Catherine M", "initials": "CM"}, {"family": "Fu", "given": "Edouard L", "initials": "EL"}, {"family": "Ashur", "given": "Aurneen", "initials": "A"}, {"family": "Beale", "given": "Rupert C L", "initials": "RCL"}, {"family": "Clase", "given": "Imogen A", "initials": "IA"}, {"family": "Dolovich", "given": "Myrna B", "initials": "MB"}, {"family": "Jardine", "given": "Meg J", "initials": "MJ"}, {"family": "Joseph", "given": "Meera", "initials": "M"}, {"family": "Kansiime", "given": "Grace", "initials": "G"}, {"family": "Mann", "given": "Johannes F E", "initials": "JFE"}, {"family": "Pecoits-Filho", "given": "Roberto", "initials": "R"}, {"family": "Winkelmayer", "given": "Wolfgang C", "initials": "WC"}, {"family": "Carrero", "given": "Juan J", "initials": "JJ"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Mayo Clin Proc", "issn": "1942-5546", "volume": "95", "issue": "10", "pages": "2204-2224", "issn-l": "0025-6196"}, "abstract": "Management of the global crisis of the coronavirus disease 2019 pandemic requires detailed appraisal of evidence to support clear, actionable, and consistent public health messaging. The use of cloth masks for general public use is being debated, and is in flux. We searched the MEDLINE and EMBASE databases and Google for articles reporting the filtration properties of flat cloth or cloth masks. We reviewed the reference lists of relevant articles to identify further articles and identified articles through social and conventional news media. We found 25 articles. Study of protection for the wearer used healthy volunteers, or used a manikin wearing a mask, with airflow to simulate different breathing rates. Studies of protection of the environment, also known as source control, used convenience samples of healthy volunteers. The design and execution of the studies was generally rigorously described. Many descriptions of cloth lacked the detail required for reproducibility; no study provided all the expected details of material, thread count, weave, and weight. Some of the homemade mask designs were reproducible. Successful masks were made of muslin at 100 threads per inch (TPI) in 3 to 4 layers (4-layer muslin or a muslin-flannel-muslin sandwich), tea towels (also known as dish towels), made using 1 layer (2 layers would be expected to be better), and good-quality cotton T-shirts in 2 layers (with a stitched edge to prevent stretching). In flat-cloth experiments, linen tea towels, 600-TPI cotton in 2 layers, and 600-TPI cotton with 90-TPI flannel performed well but 80-TPI cotton in 2 layers did not. We therefore recommend cotton or flannel at least 100 TPI, at least 2 layers. More layers, 3 or 4, will provide increased filtration but there is a trade-off in that more layers increases the resistance to breathing. Although this is not a systematic review, we included all the articles that we identified in an unbiased way. We did not include gray literature or preprints. A plain language summary of these data and recommendations, as well as information on making, wearing and cleaning cloth masks is available at www.clothmasks.ca.", "doi": "10.1016/j.mayocp.2020.07.020", "pmid": "33012350", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0025-6196(20)30826-0"}], "notes": [], "created": "2020-11-26T12:30:06.960Z", "modified": "2020-11-26T12:30:06.978Z"}, {"entity": "publication", "iuid": "4e6914020d7d475d935aa1ca7e8a49e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4e6914020d7d475d935aa1ca7e8a49e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4e6914020d7d475d935aa1ca7e8a49e7"}}, "title": "Existing highly accumulating lysosomotropic drugs with potential for repurposing to target COVID-19.", "authors": [{"family": "Norinder", "given": "Ulf", "initials": "U"}, {"family": "Tuck", "given": "Astrud", "initials": "A"}, {"family": "Norgren", "given": "Kalle", "initials": "K"}, {"family": "Munic Kos", "given": "Vesna", "initials": "V"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Biomed Pharmacother", "issn": "1950-6007", "volume": "130", "issue": null, "pages": "110582", "issn-l": "0753-3322"}, "abstract": "Given the speed of viral infection spread, repurposing of existing drugs has been given the highest priority in combating the ongoing COVID-19 pandemic. Only drugs that are already registered or close to registration, and therefore have passed lengthy safety assessments, have a chance to be tested in clinical trials and reach patients quickly enough to help in the current disease outbreak. Here, we have reviewed available evidence and possible ways forward to identify already existing pharmaceuticals displaying modest broad-spectrum antiviral activity which is likely linked to their high accumulation in cells. Several well studied examples indicate that these drugs accumulate in lysosomes, endosomes and biological membranes in general, and thereby interfere with endosomal pathway and intracellular membrane trafficking crucial for viral infection. With the aim to identify other lysosomotropic drugs with possible inherent antiviral activity, we have applied a set of clear physicochemical, pharmacokinetic and molecular criteria on 530 existing drugs. In addition to publicly available data, we have also used our in silico model for the prediction of accumulation in lysosomes and endosomes. By this approach we have identified 36 compounds with possible antiviral effects, also against coronaviruses. For 14 of them evidence of broad-spectrum antiviral activity has already been reported, adding support to the value of this approach. Presented pros and cons, knowledge gaps and methods to identify lysosomotropic antivirals, can help in the evaluation of many drugs currently in clinical trials considered for repurposing to target COVID-19, as well as open doors to finding more potent and safer alternatives.", "doi": "10.1016/j.biopha.2020.110582", "pmid": "32763818", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0753-3322(20)30775-7"}, {"db": "pmc", "key": "PMC7392152"}], "notes": [], "created": "2020-11-26T12:31:26.600Z", "modified": "2020-11-30T08:42:55.516Z"}, {"entity": "publication", "iuid": "8c3b72858d46451ba01f4721713ac968", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c3b72858d46451ba01f4721713ac968.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c3b72858d46451ba01f4721713ac968"}}, "title": "European Hernia Society (EHS) guidance for the management of adult patients with a hernia during the COVID-19 pandemic.", "authors": [{"family": "Stabilini", "given": "C", "initials": "C"}, {"family": "East", "given": "B", "initials": "B"}, {"family": "Fortelny", "given": "R", "initials": "R"}, {"family": "Gillion", "given": "J-F", "initials": "J"}, {"family": "Lorenz", "given": "R", "initials": "R"}, {"family": "Montgomery", "given": "A", "initials": "A"}, {"family": "Morales-Conde", "given": "S", "initials": "S"}, {"family": "Muysoms", "given": "F", "initials": "F"}, {"family": "Pawlak", "given": "M", "initials": "M"}, {"family": "Reinpold", "given": "W", "initials": "W"}, {"family": "Simons", "given": "M", "initials": "M"}, {"family": "de Beaux", "given": "A C", "initials": "AC"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Hernia", "issn": "1248-9204", "issn-l": null, "volume": "24", "issue": "5", "pages": "977-983"}, "abstract": null, "doi": "10.1007/s10029-020-02212-8", "pmid": "32415652", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10029-020-02212-8"}, {"db": "pmc", "key": "PMC7227454"}], "notes": [], "created": "2020-12-10T08:53:10.937Z", "modified": "2020-12-11T14:19:18.837Z"}, {"entity": "publication", "iuid": "75c67caf246e413986c2d887261bb7d2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/75c67caf246e413986c2d887261bb7d2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/75c67caf246e413986c2d887261bb7d2"}}, "title": "Epidemic and pandemic viral infections: impact on tuberculosis and the lung: A consensus by the World Association for Infectious Diseases and Immunological Disorders (WAidid), Global Tuberculosis Network (GTN), and members of the European Society of Clinical Microbiology and Infectious Diseases Study Group for Mycobacterial Infections (ESGMYC).", "authors": [{"family": "Ong", "given": "Catherine Wei Min", "initials": "CWM"}, {"family": "Migliori", "given": "Giovanni Battista", "initials": "GB"}, {"family": "Raviglione", "given": "Mario", "initials": "M"}, {"family": "MacGregor-Skinner", "given": "Gavin", "initials": "G"}, {"family": "Sotgiu", "given": "Giovanni", "initials": "G"}, {"family": "Alffenaar", "given": "Jan-Willem", "initials": "JW"}, {"family": "Tiberi", "given": "Simon", "initials": "S"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Alonzi", "given": "Tonino", "initials": "T"}, {"family": "Archuleta", "given": "Sophia", "initials": "S"}, {"family": "Brusin", "given": "Sergio", "initials": "S"}, {"family": "Cambau", "given": "Emmanuelle", "initials": "E"}, {"family": "Capobianchi", "given": "Maria Rosaria", "initials": "MR"}, {"family": "Castilletti", "given": "Concetta", "initials": "C"}, {"family": "Centis", "given": "Rosella", "initials": "R"}, {"family": "Cirillo", "given": "Daniela M", "initials": "DM"}, {"family": "D'Ambrosio", "given": "Lia", "initials": "L"}, {"family": "Delogu", "given": "Giovanni", "initials": "G"}, {"family": "Esposito", "given": "Susanna M R", "initials": "SMR"}, {"family": "Figueroa", "given": "Jose", "initials": "J"}, {"family": "Friedland", "given": "Jon S", "initials": "JS"}, {"family": "Ho", "given": "Benjamin Choon Heng", "initials": "BCH"}, {"family": "Ippolito", "given": "Giuseppe", "initials": "G"}, {"family": "Jankovic", "given": "Mateja", "initials": "M"}, {"family": "Kim", "given": "Hannah Yejin", "initials": "HY"}, {"family": "Rosales Klintz", "given": "Senia", "initials": "S"}, {"family": "K\u00f6dm\u00f6n", "given": "Csaba", "initials": "C"}, {"family": "Lalle", "given": "Eleonora", "initials": "E"}, {"family": "Leo", "given": "Yee Sin", "initials": "YS"}, {"family": "Leung", "given": "Chi-Chiu", "initials": "CC"}, {"family": "M\u00e4rtson", "given": "Anne-Grete", "initials": "AG"}, {"family": "Melazzini", "given": "Mario Giovanni", "initials": "MG"}, {"family": "Najafi Fard", "given": "Saeid", "initials": "S"}, {"family": "Penttinen", "given": "Pasi", "initials": "P"}, {"family": "Petrone", "given": "Linda", "initials": "L"}, {"family": "Petruccioli", "given": "Elisa", "initials": "E"}, {"family": "Pontali", "given": "Emanuele", "initials": "E"}, {"family": "Saderi", "given": "Laura", "initials": "L"}, {"family": "Santin", "given": "Miguel", "initials": "M"}, {"family": "Spanevello", "given": "Antonio", "initials": "A"}, {"family": "van Crevel", "given": "Reinout", "initials": "R"}, {"family": "van der Werf", "given": "Marieke J", "initials": "MJ"}, {"family": "Visca", "given": "Dina", "initials": "D"}, {"family": "Viveiros", "given": "Miguel", "initials": "M"}, {"family": "Zellweger", "given": "Jean-Pierre", "initials": "JP"}, {"family": "Zumla", "given": "Alimuddin", "initials": "A"}, {"family": "Goletti", "given": "Delia", "initials": "D"}], "type": "consensus development conference", "published": "2020-10-00", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "volume": "56", "issue": "4", "issn-l": "0903-1936"}, "abstract": "Major epidemics, including some that qualify as pandemics, such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), HIV, influenza A (H1N1)pdm/09 and most recently COVID-19, affect the lung. Tuberculosis (TB) remains the top infectious disease killer, but apart from syndemic TB/HIV little is known regarding the interaction of viral epidemics and pandemics with TB. The aim of this consensus-based document is to describe the effects of viral infections resulting in epidemics and pandemics that affect the lung (MERS, SARS, HIV, influenza A (H1N1)pdm/09 and COVID-19) and their interactions with TB. A search of the scientific literature was performed. A writing committee of international experts including the European Centre for Disease Prevention and Control Public Health Emergency (ECDC PHE) team, the World Association for Infectious Diseases and Immunological Disorders (WAidid), the Global Tuberculosis Network (GTN), and members of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Mycobacterial Infections (ESGMYC) was established. Consensus was achieved after multiple rounds of revisions between the writing committee and a larger expert group. A Delphi process involving the core group of authors (excluding the ECDC PHE team) identified the areas requiring review/consensus, followed by a second round to refine the definitive consensus elements. The epidemiology and immunology of these viral infections and their interactions with TB are discussed with implications for diagnosis, treatment and prevention of airborne infections (infection control, viral containment and workplace safety). This consensus document represents a rapid and comprehensive summary on what is known on the topic.", "doi": "10.1183/13993003.01727-2020", "pmid": "32586885", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "13993003.01727-2020"}, {"db": "pmc", "key": "PMC7527651"}], "notes": [], "created": "2020-11-30T08:54:54.178Z", "modified": "2020-11-30T08:54:54.189Z"}, {"entity": "publication", "iuid": "3225f0c765e1457992c1dfecb0cc699e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3225f0c765e1457992c1dfecb0cc699e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3225f0c765e1457992c1dfecb0cc699e"}}, "title": "Effect of the COVID-19 pandemic response on intrapartum care, stillbirth, and neonatal mortality outcomes in Nepal: a prospective observational study.", "authors": [{"family": "Kc", "given": "Ashish", "initials": "A"}, {"family": "Gurung", "given": "Rejina", "initials": "R"}, {"family": "Kinney", "given": "Mary V", "initials": "MV"}, {"family": "Sunny", "given": "Avinash K", "initials": "AK"}, {"family": "Moinuddin", "given": "Md", "initials": "M"}, {"family": "Basnet", "given": "Omkar", "initials": "O"}, {"family": "Paudel", "given": "Prajwal", "initials": "P"}, {"family": "Bhattarai", "given": "Pratiksha", "initials": "P"}, {"family": "Subedi", "given": "Kalpana", "initials": "K"}, {"family": "Shrestha", "given": "Mahendra Prasad", "initials": "MP"}, {"family": "Lawn", "given": "Joy E", "initials": "JE"}, {"family": "M\u00e5lqvist", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Lancet Glob Health", "issn": "2214-109X", "issn-l": null, "volume": "8", "issue": "10", "pages": "e1273-e1281"}, "abstract": "The COVID-19 pandemic response is affecting maternal and neonatal health services all over the world. We aimed to assess the number of institutional births, their outcomes (institutional stillbirth and neonatal mortality rate), and quality of intrapartum care before and during the national COVID-19 lockdown in Nepal.\r\n\r\nIn this prospective observational study, we collected participant-level data for pregnant women enrolled in the SUSTAIN and REFINE studies between Jan 1 and May 30, 2020, from nine hospitals in Nepal. This period included 12\u00b75 weeks before the national lockdown and 9\u00b75 weeks during the lockdown. Women were eligible for inclusion if they had a gestational age of 22 weeks or more, a fetal heart sound at time of admission, and consented to inclusion. Women who had multiple births and their babies were excluded. We collected information on demographic and obstetric characteristics via extraction from case notes and health worker performance via direct observation by independent clinical researchers. We used regression analyses to assess changes in the number of institutional births, quality of care, and mortality before lockdown versus during lockdown.\r\n\r\nOf 22 907 eligible women, 21 763 women were enrolled and 20 354 gave birth, and health worker performance was recorded for 10 543 births. From the beginning to the end of the study period, the mean weekly number of births decreased from 1261\u00b71 births (SE 66\u00b71) before lockdown to 651\u00b74 births (49\u00b79) during lockdown-a reduction of 52\u00b74%. The institutional stillbirth rate increased from 14 per 1000 total births before lockdown to 21 per 1000 total births during lockdown (p=0\u00b70002), and institutional neonatal mortality increased from 13 per 1000 livebirths to 40 per 1000 livebirths (p=0\u00b70022). In terms of quality of care, intrapartum fetal heart rate monitoring decreased by 13\u00b74% (-15\u00b74 to -11\u00b73; p<0\u00b70001), and breastfeeding within 1 h of birth decreased by 3\u00b75% (-4\u00b76 to -2\u00b76; p=0\u00b70032). The immediate newborn care practice of placing the baby skin-to-skin with their mother increased by 13\u00b72% (12\u00b71 to 14\u00b75; p<0\u00b70001), and health workers' hand hygiene practices during childbirth increased by 12\u00b79% (11\u00b78 to 13\u00b79) during lockdown (p<0\u00b70001).\r\n\r\nInstitutional childbirth reduced by more than half during lockdown, with increases in institutional stillbirth rate and neonatal mortality, and decreases in quality of care. Some behaviours improved, notably hand hygiene and keeping the baby skin-to-skin with their mother. An urgent need exists to protect access to high quality intrapartum care and prevent excess deaths for the most vulnerable health system users during this pandemic period.\r\n\r\nGrand Challenges Canada.", "doi": "10.1016/S2214-109X(20)30345-4", "pmid": "32791117", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2214-109X(20)30345-4"}, {"db": "pmc", "key": "PMC7417164"}], "notes": [], "created": "2020-12-07T13:25:40.521Z", "modified": "2021-02-26T08:46:59.892Z"}, {"entity": "publication", "iuid": "8da6e2c62015459089ced85518bfb9cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8da6e2c62015459089ced85518bfb9cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8da6e2c62015459089ced85518bfb9cb"}}, "title": "Education for sustainable healthcare: Leadership to get from here to there.", "authors": [{"family": "McKimm", "given": "Judy", "initials": "J"}, {"family": "Redvers", "given": "Nicole", "initials": "N"}, {"family": "El Omrani", "given": "Omnia", "initials": "O"}, {"family": "Parkes", "given": "Margot W", "initials": "MW"}, {"family": "Elf", "given": "Marie", "initials": "M"}, {"family": "Woollard", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Med Teach", "issn": "1466-187X", "volume": "42", "issue": "10", "pages": "1123-1127", "issn-l": null}, "abstract": "The current global crises, including climate, COVID-19, and environmental change, requires global collective action at all scales. These broad socio-ecological challenges require the engagement of diverse perspectives and ways of knowing and the meaningful engagement of all generations and stages of personal and professional development. The combination of systems thinking, change management, quality improvement approaches and models, appreciative/strength-based approaches, narratives, storytelling and the strengths of Indigenous knowledges, offer synergies and potential that can set the stage for transformative, strengths-based education for sustainable healthcare (ESH). The need for strong leadership to enact a vision for ESH is outlined here with the intent to enable and nurture the conditions for change, ultimately improving health and well-being across generations.", "doi": "10.1080/0142159X.2020.1795104", "pmid": "32776858", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-07T13:32:42.469Z", "modified": "2020-12-07T13:32:42.488Z"}, {"entity": "publication", "iuid": "b15ba4b711654135a2ba50602ff79c98", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b15ba4b711654135a2ba50602ff79c98.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b15ba4b711654135a2ba50602ff79c98"}}, "title": "EXPOSED: An occupant exposure model for confined spaces to retrofit crowd models during a pandemic.", "authors": [{"family": "Ronchi", "given": "Enrico", "initials": "E"}, {"family": "Lovreglio", "given": "Ruggiero", "initials": "R"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Saf Sci", "issn": "0925-7535", "volume": "130", "issue": null, "pages": "104834", "issn-l": null}, "abstract": "Crowd models can be used for the simulation of people movement in the built environment. Crowd model outputs have been used for evaluating safety and comfort of pedestrians, inform crowd management and perform forensic investigations. Microscopic crowd models allow the representation of each person and the obtainment of information concerning their location over time and interactions with the physical space/other people. Pandemics such as COVID-19 have posed several questions on safe building usage, given the risk of disease transmission among building occupants. Here we show how crowd modelling can be used to assess occupant exposure in confined spaces. The policies adopted concerning building usage and social distancing during a pandemic can vary greatly, and they are mostly based on the macroscopic analysis of the spread of disease rather than a safety assessment performed at a building level. The proposed model allows the investigation of occupant exposure in buildings based on the analysis of microscopic people movement. Risk assessment is performed by retrofitting crowd models with a universal model for exposure assessment which can account for different types of disease transmissions. This work allows policy makers to perform informed decisions concerning building usage during a pandemic.", "doi": "10.1016/j.ssci.2020.104834", "pmid": "32834509", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0925-7535(20)30231-9"}, {"db": "pii", "key": "104834"}, {"db": "pmc", "key": "PMC7373681"}], "notes": [], "created": "2020-12-07T11:44:35.957Z", "modified": "2020-12-07T11:44:35.981Z"}, {"entity": "publication", "iuid": "171bcce7a979419cb54729a50448495c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/171bcce7a979419cb54729a50448495c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/171bcce7a979419cb54729a50448495c"}}, "title": "Dying From COVID-19: Loneliness, End-of-Life Discussions, and Support for Patients and Their Families in Nursing Homes and Hospitals. A National Register Study.", "authors": [{"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "Bergstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Martinsson", "given": "Lisa", "initials": "L"}, {"family": "Lundstr\u00f6m", "given": "Staffan", "initials": "S"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "J Pain Symptom Manage", "issn": "1873-6513", "issn-l": null, "volume": "60", "issue": "4", "pages": "e2-e13"}, "abstract": "Preparation for an impending death through end-of-life (EOL) discussions and human presence when a person is dying is important for both patients and families.\r\n\r\nThe aim was to study whether EOL discussions were offered and to what degree patients were alone at time of death when dying from coronavirus disease 2019 (COVID-19), comparing deaths in nursing homes and hospitals.\r\n\r\nThe national Swedish Register of Palliative Care was used. All expected deaths from COVID-19 in nursing homes and hospitals were compared with, and contrasted to, deaths in a reference population (deaths in 2019).\r\n\r\nA total of 1346 expected COVID-19 deaths in nursing homes (n = 908) and hospitals (n = 438) were analyzed. Those who died were of a more advanced age in nursing homes (mean 86.4 years) and of a lower age in hospitals (mean 80.7 years) (P < 0.0001). Fewer EOL discussions with patients were held compared with deaths in 2019 (74% vs. 79%, P < 0.001), and dying with someone present was much more uncommon (59% vs. 83%, P < 0.0001). In comparisons between nursing homes and hospital deaths, more patients dying in nursing homes were women (56% vs. 37%, P < 0.0001), and significantly fewer had a retained ability to express their will during the last week of life (54% vs. 89%, P < 0.0001). Relatives were present at time of death in only 13% and 24% of the cases in nursing homes and hospitals, respectively (P < 0.001). The corresponding figures for staff were 52% and 38% (P < 0.0001).\r\n\r\nDying from COVID-19 negatively affects the possibility of holding an EOL discussion and the chances of dying with someone present. This has considerable social and existential consequences for both patients and families.", "doi": "10.1016/j.jpainsymman.2020.07.020", "pmid": "32721500", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0885-3924(20)30630-8"}, {"db": "pmc", "key": "PMC7382350"}], "notes": [], "created": "2020-12-07T16:09:21.631Z", "modified": "2022-11-09T09:09:59.506Z"}, {"entity": "publication", "iuid": "abaafb213d3642919cb71f28b80149e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abaafb213d3642919cb71f28b80149e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abaafb213d3642919cb71f28b80149e7"}}, "title": "Dealing with uncertainty after transplantation in times of COVID-19.", "authors": [{"family": "Massey", "given": "Emma K", "initials": "EK"}, {"family": "Forsberg", "given": "Anna", "initials": "A"}], "type": "letter", "published": "2020-10-00", "journal": {"title": "Transpl Int", "issn": "1432-2277", "volume": "33", "issue": "10", "pages": "1337-1338", "issn-l": null}, "abstract": null, "doi": "10.1111/tri.13709", "pmid": "32725696", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-07T16:08:11.914Z", "modified": "2020-12-07T16:08:30.213Z"}, {"entity": "publication", "iuid": "5cfabeea139c408f8f4fab4b47469ca0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5cfabeea139c408f8f4fab4b47469ca0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5cfabeea139c408f8f4fab4b47469ca0"}}, "title": "Dataset of knowledge, attitude, practices and psychological implications of healthcare workers in Pakistan during COVID-19 pandemic.", "authors": [{"family": "Qasim", "given": "Muhammad", "initials": "M"}, {"family": "Awan", "given": "Usman Ayub", "initials": "UA"}, {"family": "Afzal", "given": "Muhammad Sohail", "initials": "MS"}, {"family": "Saqib", "given": "Muhammad Arif Nadeem", "initials": "MAN"}, {"family": "Siddiqui", "given": "Shajee", "initials": "S"}, {"family": "Ahmed", "given": "Haroon", "initials": "H"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Data Brief", "issn": "2352-3409", "issn-l": null, "volume": "32", "issue": null, "pages": "106234"}, "abstract": "The COVID-19 pandemic has created a global health emergency and has a huge impact on the health care workers, especially on their mental health. The dataset presented was an assessment of COVID-19 related knowledge, attitude, practices and its effects on the mental health of frontline healthcare workers in Pakistan. The data were collected using a snowball sampling technique. A questionnaire was developed assessing sociodemographic characteristics (6 items), knowledge (11 items), attitude (5 items), practices (6 items), information sources (1 item) and psychological implications (12 items) and distributed using online tools. The dataset includes 476 healthcare workers in Pakistan. The dataset will help to prevent and curb the spread of COVID-19 among health workers and contribute to policymakers. Furthermore, our dataset provides detailed insights into different risk factors of psychological problems, and it may be served as the reference for various in-depth surveys.", "doi": "10.1016/j.dib.2020.106234", "pmid": "32895632", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S2352-3409(20)31128-8"}, {"db": "pii", "key": "106234"}, {"db": "pmc", "key": "PMC7462453"}], "notes": [], "created": "2020-12-06T07:21:44.969Z", "modified": "2022-11-09T09:10:37.633Z"}, {"entity": "publication", "iuid": "4796c127b3264e32a6831ad545b0ff92", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4796c127b3264e32a6831ad545b0ff92.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4796c127b3264e32a6831ad545b0ff92"}}, "title": "Comprehensive investigation of an in-hospital transmission cluster of a symptomatic SARS-CoV-2-positive physician among patients and healthcare workers in Germany.", "authors": [{"family": "Wendt", "given": "Ralph", "initials": "R"}, {"family": "Nagel", "given": "Stephan", "initials": "S"}, {"family": "Nickel", "given": "Olaf", "initials": "O"}, {"family": "Wolf", "given": "Johannes", "initials": "J"}, {"family": "Kalbitz", "given": "Sven", "initials": "S"}, {"family": "Kaiser", "given": "Thorsten", "initials": "T"}, {"family": "Borte", "given": "Stephan", "initials": "S"}, {"family": "L\u00fcbbert", "given": "Christoph", "initials": "C"}], "type": "case reports", "published": "2020-10-00", "journal": {"title": "Infect Control Hosp Epidemiol", "issn": "1559-6834", "volume": "41", "issue": "10", "pages": "1209-1211", "issn-l": "0899-823X"}, "abstract": "We investigated potential transmissions of a symptomatic SARS-CoV-2-positive physician in a tertiary-care hospital who worked for 15 cumulative hours without wearing a face mask. No in-hospital transmissions occurred, despite 254 contacts among patients and healthcare workers. In conclusion, exposed hospital staff continued work, accompanied by close clinical and virologic monitoring.", "doi": "10.1017/ice.2020.268", "pmid": "32489162", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0899823X20002688"}, {"db": "pmc", "key": "PMC7298077"}], "notes": [], "created": "2020-11-25T09:41:22.284Z", "modified": "2021-02-26T08:45:48.105Z"}, {"entity": "publication", "iuid": "85157ee446f24772b44d5e9ac2539b9e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/85157ee446f24772b44d5e9ac2539b9e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/85157ee446f24772b44d5e9ac2539b9e"}}, "title": "Clarifications on Technologies to Optimize Care of Severe COVID-19 Patients.", "authors": [{"family": "Brull", "given": "Sorin J", "initials": "SJ"}, {"family": "Kopman", "given": "Aaron F", "initials": "AF"}], "type": "letter", "published": "2020-10-00", "journal": {"title": "Anesth Analg", "issn": "1526-7598", "volume": "131", "issue": "4", "pages": "e192-e193", "issn-l": null}, "abstract": null, "doi": "10.1213/ANE.0000000000005120", "pmid": "32665462", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7365583"}], "notes": [], "created": "2020-12-07T16:38:42.283Z", "modified": "2020-12-07T16:38:42.308Z"}, {"entity": "publication", "iuid": "0d54d30ef4aa4861a056b01048b810d1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d54d30ef4aa4861a056b01048b810d1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d54d30ef4aa4861a056b01048b810d1"}}, "title": "COVID-19, Mental Health, and Religious Coping Among American Orthodox Jews.", "authors": [{"family": "Pirutinsky", "given": "Steven", "initials": "S"}, {"family": "Cherniak", "given": "Aaron D", "initials": "AD"}, {"family": "Rosmarin", "given": "David H", "initials": "DH"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "J Relig Health", "issn": "1573-6571", "issn-l": null, "volume": "59", "issue": "5", "pages": "2288-2301"}, "abstract": "The COVID-19 pandemic presents potential mental health challenges, and the American Orthodox Jewish population has been particularly affected by the virus. The current study assessed the impact of the pandemic and explored the relationships between exposure, religiosity, and distress in a sample of n = 419 American Orthodox Jews. Results indicated high levels of exposure, concern, and compliance with medical guidelines; however stress was generally low and we found evidence for positive impact. Direct exposure correlated with higher religiosity. Positive religious coping, intrinsic religiosity and trust in God strongly correlated with less stress and more positive impact, while negative religious coping and mistrust in God correlated with the inverse. While the study is limited by its design, findings highlight that for some, faith may promote resilience especially during crisis.", "doi": "10.1007/s10943-020-01070-z", "pmid": "32705481", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10943-020-01070-z"}, {"db": "pmc", "key": "PMC7377309"}], "notes": [], "created": "2020-12-07T16:20:30.936Z", "modified": "2022-11-09T09:11:03.183Z"}, {"entity": "publication", "iuid": "5631ba3e9abe4a2c85c782382fa3aa01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5631ba3e9abe4a2c85c782382fa3aa01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5631ba3e9abe4a2c85c782382fa3aa01"}}, "title": "COVID-19 and the brain: impact on nuclear medicine in neurology.", "authors": [{"family": "Morbelli", "given": "Silvia", "initials": "S"}, {"family": "Ekmekcioglu", "given": "Ozgul", "initials": "O"}, {"family": "Barthel", "given": "Henryk", "initials": "H"}, {"family": "Albert", "given": "Nathalie L", "initials": "NL"}, {"family": "Boellaard", "given": "Ronald", "initials": "R"}, {"family": "Cecchin", "given": "Diego", "initials": "D"}, {"family": "Guedj", "given": "Eric", "initials": "E"}, {"family": "Lammertsma", "given": "Adriaan A", "initials": "AA"}, {"family": "Law", "given": "Ian", "initials": "I"}, {"family": "Penuelas", "given": "Ivan", "initials": "I"}, {"family": "Semah", "given": "Franck", "initials": "F"}, {"family": "Traub-Weidinger", "given": "Tatjana", "initials": "T"}, {"family": "van de Giessen", "given": "Elsmarieke", "initials": "E"}, {"family": "Varrone", "given": "Andrea", "initials": "A"}, {"family": "Garibotto", "given": "Valentina", "initials": "V"}, {"family": "EANM Neuroimaging Committee", "given": "", "initials": ""}], "type": "editorial", "published": "2020-10-00", "journal": {"title": "Eur J Nucl Med Mol Imaging", "issn": "1619-7089", "volume": "47", "issue": "11", "pages": "2487-2492", "issn-l": null}, "abstract": null, "doi": "10.1007/s00259-020-04965-x", "pmid": "32700058", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00259-020-04965-x"}, {"db": "pmc", "key": "PMC7375837"}], "notes": [], "created": "2020-12-07T16:22:42.972Z", "modified": "2020-12-07T16:22:42.994Z"}, {"entity": "publication", "iuid": "22760662d260465e845d059e37f99921", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/22760662d260465e845d059e37f99921.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/22760662d260465e845d059e37f99921"}}, "title": "COVID-19 and mental health among older people in Sweden.", "authors": [{"family": "Skoog", "given": "Ingmar", "initials": "I"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Int Psychogeriatr", "issn": "1741-203X", "volume": "32", "issue": "10", "pages": "1173-1175", "issn-l": null}, "abstract": null, "doi": "10.1017/S104161022000143X", "pmid": "32635950", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S104161022000143X"}, {"db": "pmc", "key": "PMC7403743"}], "notes": [], "created": "2020-12-08T14:34:03.903Z", "modified": "2020-12-08T14:34:03.926Z"}, {"entity": "publication", "iuid": "6bb2344e298d441e9b2aa29db8f34878", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6bb2344e298d441e9b2aa29db8f34878.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6bb2344e298d441e9b2aa29db8f34878"}}, "title": "Build back stronger universal health coverage systems after the COVID-19 pandemic: the need for better governance and linkage with universal social protection.", "authors": [{"family": "Tediosi", "given": "Fabrizio", "initials": "F"}, {"family": "L\u00f6nnroth", "given": "Knut", "initials": "K"}, {"family": "Pablos-M\u00e9ndez", "given": "Ariel", "initials": "A"}, {"family": "Raviglione", "given": "Mario", "initials": "M"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "issn-l": "2059-7908", "volume": "5", "issue": "10", "pages": null}, "abstract": "Commentary", "doi": "10.1136/bmjgh-2020-004020", "pmid": "33122298", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-004020"}, {"db": "pmc", "key": "PMC7597511"}], "notes": [], "created": "2020-11-27T10:19:52.601Z", "modified": "2022-11-09T09:12:02.304Z"}, {"entity": "publication", "iuid": "be2ebedd6233495a88eb38cb95b66764", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be2ebedd6233495a88eb38cb95b66764.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be2ebedd6233495a88eb38cb95b66764"}}, "title": "Assessing the fear of COVID-19 among different populations: A response to Ransing et al. (2020).", "authors": [{"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Chang", "given": "Kun-Chia", "initials": "KC"}, {"family": "Chen", "given": "Yu-Pin", "initials": "YP"}, {"family": "Kuo", "given": "Yi-Jie", "initials": "YJ"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}], "type": "letter", "published": "2020-10-00", "journal": {"title": "Brain Behav Immun", "issn": "1090-2139", "volume": "89", "issue": null, "pages": "524-525", "issn-l": null}, "abstract": null, "doi": "10.1016/j.bbi.2020.06.006", "pmid": "32512132", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0889-1591(20)31198-3"}, {"db": "pmc", "key": "PMC7274088"}], "notes": [], "created": "2020-12-09T10:33:23.328Z", "modified": "2020-12-09T10:33:23.350Z"}, {"entity": "publication", "iuid": "d1bb3e2646f840f3bacba6c587c03e3a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1bb3e2646f840f3bacba6c587c03e3a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1bb3e2646f840f3bacba6c587c03e3a"}}, "title": "Advocacy for the human rights of older people in the COVID pandemic and beyond: a call to mental health professionals.", "authors": [{"family": "Peisah", "given": "Carmelle", "initials": "C"}, {"family": "Byrnes", "given": "Andrew", "initials": "A"}, {"family": "Doron", "given": "Israel Issi", "initials": "II"}, {"family": "Dark", "given": "Michael", "initials": "M"}, {"family": "Quinn", "given": "Gerard", "initials": "G"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Int Psychogeriatr", "issn": "1741-203X", "issn-l": null, "volume": "32", "issue": "10", "pages": "1199-1204"}, "abstract": null, "doi": "10.1017/S1041610220001076", "pmid": "32487280", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1041610220001076"}, {"db": "pmc", "key": "PMC7302948"}], "notes": [], "created": "2020-12-09T10:53:49.868Z", "modified": "2020-12-11T12:49:56.181Z"}, {"entity": "publication", "iuid": "3ae6115f8aed497694523e954dd74313", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ae6115f8aed497694523e954dd74313.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ae6115f8aed497694523e954dd74313"}}, "title": "Adaptation of evidence-based suicide prevention strategies during and after the COVID-19 pandemic.", "authors": [{"family": "Wasserman", "given": "Danuta", "initials": "D"}, {"family": "Iosue", "given": "Miriam", "initials": "M"}, {"family": "Wuestefeld", "given": "Anika", "initials": "A"}, {"family": "Carli", "given": "Vladimir", "initials": "V"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "World Psychiatry", "issn": "1723-8617", "volume": "19", "issue": "3", "pages": "294-306", "issn-l": null}, "abstract": "Suicide is preventable. Nevertheless, each year 800,000 people die of suicide in the world. While there is evidence indicating that suicide rates de-crease during times of crises, they are expected to increase once the immediate crisis has passed. The COVID-19 pandemic affects risk and pro-tective factors for suicide at each level of the socio-ecological model. Economic downturn, augmented barriers to accessing health care, increased access to suicidal means, inappropriate media reporting at the societal level; deprioritization of mental health and preventive activities at the community level; interpersonal conflicts, neglect and violence at the relationship level; unemployment, poverty, loneliness and hopelessness at the individual level: all these variables contribute to an increase of depression, anxiety, post-traumatic stress disorder, harmful use of alcohol, substance abuse, and ultimately suicide risk. Suicide should be prevented by strengthening universal strategies directed to the entire population, including mitigation of unemployment, poverty and inequalities; prioritization of access to mental health care; responsible media reporting, with information about available support; prevention of increased alcohol intake; and restriction of access to lethal means of suicide. Selective interventions should continue to target known vulnerable groups who are socio-economically disadvantaged, but also new ones such as first responders and health care staff, and the bereaved by COVID-19 who have been deprived of the final contact with loved ones and funerals. Indicated preventive strategies targeting individuals who display suicidal behaviour should focus on available pharmacological and psychological treatments of mental disorders, ensuring proper follow-up and chain of care by increased use of telemedicine and other digital means. The scientific community, health care professionals, politicians and decision-makers will find in this paper a systematic description of the effects of the pandemic on suicide risk at the society, community, family and individual levels, and an overview of how evidence-based suicide preventive interventions should be adapted. Research is needed to investigate which adaptations are effective and in which con-texts.", "doi": "10.1002/wps.20801", "pmid": "32931107", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7491639"}], "notes": [], "created": "2020-12-03T15:34:27.996Z", "modified": "2020-12-03T15:34:28.019Z"}, {"entity": "publication", "iuid": "c6465dd934734f92a6dcc63a323d6953", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c6465dd934734f92a6dcc63a323d6953.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c6465dd934734f92a6dcc63a323d6953"}}, "title": "ATMO-vent: An adapted breathing atmosphere for COVID-19 patients.", "authors": [{"family": "Mathanlal", "given": "Thasshwin", "initials": "T"}, {"family": "Israel Nazarious", "given": "Miracle", "initials": "M"}, {"family": "Mantas-Nakhai", "given": "Roberto", "initials": "R"}, {"family": "Zorzano", "given": "Maria-Paz", "initials": "MP"}, {"family": "Martin-Torres", "given": "Javier", "initials": "J"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "HardwareX", "issn": "2468-0672", "volume": "8", "issue": null, "pages": "e00145", "issn-l": null}, "abstract": "The ongoing worldwide pandemic of coronavirus disease 2019 (COVID-19), has been one of the most significant challenges to humankind in centuries. The extremely contagious nature of the SARS-CoV-2 virus has put forth an immense pressure on the health sector. In order to mitigate the stress on the healthcare systems especially to battle the crisis of mechanical ventilators, we have designed a modular, and robust DIY ventilator, ATMO-Vent (Atmospheric Mixture Optimization Ventilator) which can be fully mounted within two days by two operators. The ATMO-Vent has been designed using low-cost, robust, Commercial Off The Shelf (COTS) components, with many features comparable to a full-fledged ventilator. ATMO-Vent has been designed based on the United Kingdom Medicines & Healthcare products Regulatory Agency (UK-MHRA) guidelines for Rapidly Manufactured Ventilator System (RMVS), yet is scalable to the specific requirements of different countries. ATMO-Vent is capable of adjusting the Fraction of Inspiratory Oxygen (FiO 2) levels, Tidal Volume (TV), frequency of breaths, Inspiratory/Expiratory ratio (I/E), Peak Inspiratory Pressure (PIP) and Positive End-Expiratory Pressure (PEEP). ATMO-Vent can operate in two modes - Continuous Mandatory Ventilation (CMV) using Volume-Controlled Ventilation (VCV) and in Assisted Control (AC) mode with pressure triggered by the patient. ATMO-Vent has undergone rigorous testing and qualifies under Class B Electric and Magnetic Compatibility (EMC) requirements of EN 55,011 CISPR 11 standards.", "doi": "10.1016/j.ohx.2020.e00145", "pmid": "33015423", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2468-0672(20)30054-7"}, {"db": "pmc", "key": "PMC7518965"}], "notes": [], "created": "2020-12-03T08:52:38.086Z", "modified": "2020-12-03T08:52:38.097Z"}, {"entity": "publication", "iuid": "96f7ca266c114d4094a654bf661590b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/96f7ca266c114d4094a654bf661590b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/96f7ca266c114d4094a654bf661590b2"}}, "title": "A compendium answering 150 questions on COVID-19 and SARS-CoV-2.", "authors": [{"family": "Riggioni", "given": "Carmen", "initials": "C"}, {"family": "Comberiati", "given": "Pasquale", "initials": "P"}, {"family": "Giovannini", "given": "Mattia", "initials": "M"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Akdis", "given": "M\u00fcbeccel", "initials": "M"}, {"family": "Alves-Correia", "given": "Magna", "initials": "M"}, {"family": "Ant\u00f3", "given": "Josep M", "initials": "JM"}, {"family": "Arcolaci", "given": "Alessandra", "initials": "A"}, {"family": "Azkur", "given": "Ahmet Kursat", "initials": "AK"}, {"family": "Azkur", "given": "Dilek", "initials": "D"}, {"family": "Beken", "given": "Burcin", "initials": "B"}, {"family": "Boccabella", "given": "Cristina", "initials": "C"}, {"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Breiteneder", "given": "Heimo", "initials": "H"}, {"family": "Carvalho", "given": "Daniela", "initials": "D"}, {"family": "De Las Vecillas", "given": "Leticia", "initials": "L"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}, {"family": "Eguiluz-Gracia", "given": "Ibon", "initials": "I"}, {"family": "Eiwegger", "given": "Thomas", "initials": "T"}, {"family": "Eyerich", "given": "Stefanie", "initials": "S"}, {"family": "Fokkens", "given": "Wytske", "initials": "W"}, {"family": "Gao", "given": "Ya-Dong", "initials": "YD"}, {"family": "Hannachi", "given": "Farah", "initials": "F"}, {"family": "Johnston", "given": "Sebastian L", "initials": "SL"}, {"family": "Jutel", "given": "Marek", "initials": "M"}, {"family": "Karavelia", "given": "Aspasia", "initials": "A"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Moya", "given": "Beatriz", "initials": "B"}, {"family": "Nadeau", "given": "Kari C", "initials": "KC"}, {"family": "O'Hehir", "given": "Robyn", "initials": "R"}, {"family": "O'Mahony", "given": "Liam", "initials": "L"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Sanak", "given": "Marek", "initials": "M"}, {"family": "Schwarze", "given": "J\u00fcrgen", "initials": "J"}, {"family": "Sokolowska", "given": "Milena", "initials": "M"}, {"family": "Torres", "given": "Mar\u00eda J", "initials": "MJ"}, {"family": "van de Veen", "given": "Willem", "initials": "W"}, {"family": "van Zelm", "given": "Menno C", "initials": "MC"}, {"family": "Wang", "given": "De Yun", "initials": "Y"}, {"family": "Zhang", "given": "Luo", "initials": "L"}, {"family": "Jim\u00e9nez-Saiz", "given": "Rodrigo", "initials": "R"}, {"family": "Akdis", "given": "Cezmi A", "initials": "CA"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": "75", "issue": "10", "pages": "2503-2541", "issn-l": "0105-4538"}, "abstract": "In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date, it has resulted in ~9 million confirmed cases and caused almost 500 000 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socioeconomic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19. Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a \"cytokine storm\" leading to acute respiratory distress syndrome, endothelitis, thromboembolic complications, and multiorgan failure. The epidemiologic features of COVID-19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID-19-related topics should be based on more coordinated high-quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19, and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development, and epidemiology. A total of 150 questions were answered by experts in the field providing a comprehensive and practical overview of COVID-19 and allergic disease.", "doi": "10.1111/all.14449", "pmid": "32535955", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7323196"}], "notes": [], "created": "2020-11-30T09:00:22.912Z", "modified": "2020-11-30T09:00:22.921Z"}, {"entity": "publication", "iuid": "ef2d70107eb54e599739267f1d63e241", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef2d70107eb54e599739267f1d63e241.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef2d70107eb54e599739267f1d63e241"}}, "title": "A commentary on \"The trouble with trust: Time-series analysis of social capital, income inequality, and COVID-19 deaths in 84 countries\".", "authors": [{"family": "Lindstr\u00f6m", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Soc Sci Med", "issn": "1873-5347", "issn-l": null, "volume": "263", "issue": null, "pages": "113386"}, "abstract": "Comment\r\nThis study investigates associations between central aspects of social capital (social trust, group affiliations, civic engagement, confidence in state institutions), income inequality (Gini index for income), and COVID-19 mortality in 84 countries included in different time waves of the World Values Survey (WVS) (Elgar et al., 2020). Comments: First, infectious diseases are either patterned according to socioeconomic status (SES), determined by e.g. habitus, nutrition and crowded housing or clustering, or not according to SES. Second, the focus on economic inequality measured as income inequality (Gini index) should be complemented with measures of wealth inequality (Gini index for wealth), following the globalization process with tax exempted multinational companies. Third, the aspects of social capital were measured in different time waves of the World Values Survey (WVS) for different countries, which is a weakness because trust and other aspects of social capital vary over time and depend on specific events and social and economic trends.", "doi": "10.1016/j.socscimed.2020.113386", "pmid": "33036797", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0277-9536(20)30605-5"}, {"db": "pmc", "key": "PMC7532747"}], "notes": [], "created": "2020-12-01T17:26:58.810Z", "modified": "2020-12-01T17:27:46.293Z"}, {"entity": "publication", "iuid": "37842769c6394a15b1f9ad6e57ec202a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/37842769c6394a15b1f9ad6e57ec202a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/37842769c6394a15b1f9ad6e57ec202a"}}, "title": "Updated guidance on the management of COVID-19: from an American Thoracic Society/European Respiratory Society coordinated International Task Force (29 July 2020).", "authors": [{"family": "Bai", "given": "Chunxue", "initials": "C"}, {"family": "Chotirmall", "given": "Sanjay H", "initials": "SH"}, {"family": "Rello", "given": "Jordi", "initials": "J"}, {"family": "Alba", "given": "George A", "initials": "GA"}, {"family": "Ginns", "given": "Leo C", "initials": "LC"}, {"family": "Krishnan", "given": "Jerry A", "initials": "JA"}, {"family": "Rogers", "given": "Robert", "initials": "R"}, {"family": "Bendstrup", "given": "Elisabeth", "initials": "E"}, {"family": "Burgel", "given": "Pierre-Regis", "initials": "PR"}, {"family": "Chalmers", "given": "James D", "initials": "JD"}, {"family": "Chua", "given": "Abigail", "initials": "A"}, {"family": "Crothers", "given": "Kristina A", "initials": "KA"}, {"family": "Duggal", "given": "Abhijit", "initials": "A"}, {"family": "Kim", "given": "Yeon Wook", "initials": "YW"}, {"family": "Laffey", "given": "John G", "initials": "JG"}, {"family": "Luna", "given": "Carlos M", "initials": "CM"}, {"family": "Niederman", "given": "Michael S", "initials": "MS"}, {"family": "Raghu", "given": "Ganesh", "initials": "G"}, {"family": "Ramirez", "given": "Julio A", "initials": "JA"}, {"family": "Riera", "given": "Jordi", "initials": "J"}, {"family": "Roca", "given": "Oriol", "initials": "O"}, {"family": "Tamae-Kakazu", "given": "Maximiliano", "initials": "M"}, {"family": "Torres", "given": "Antoni", "initials": "A"}, {"family": "Watkins", "given": "Richard R", "initials": "RR"}, {"family": "Barrecheguren", "given": "Miriam", "initials": "M"}, {"family": "Belliato", "given": "Mirko", "initials": "M"}, {"family": "Chami", "given": "Hassan A", "initials": "HA"}, {"family": "Chen", "given": "Rongchang", "initials": "R"}, {"family": "Cortes-Puentes", "given": "Gustavo A", "initials": "GA"}, {"family": "Delacruz", "given": "Charles", "initials": "C"}, {"family": "Hayes", "given": "Margaret M", "initials": "MM"}, {"family": "Heunks", "given": "Leo M A", "initials": "LMA"}, {"family": "Holets", "given": "Steven R", "initials": "SR"}, {"family": "Hough", "given": "Catherine L", "initials": "CL"}, {"family": "Jagpal", "given": "Sugeet", "initials": "S"}, {"family": "Jeon", "given": "Kyeongman", "initials": "K"}, {"family": "Johkoh", "given": "Takeshi", "initials": "T"}, {"family": "Lee", "given": "May M", "initials": "MM"}, {"family": "Liebler", "given": "Janice", "initials": "J"}, {"family": "McElvaney", "given": "Gerry N", "initials": "GN"}, {"family": "Moskowitz", "given": "Ari", "initials": "A"}, {"family": "Oeckler", "given": "Richard A", "initials": "RA"}, {"family": "Ojanguren", "given": "I\u00f1igo", "initials": "I"}, {"family": "O'Regan", "given": "Anthony", "initials": "A"}, {"family": "Pletz", "given": "Mathias W", "initials": "MW"}, {"family": "Rhee", "given": "Chin Kook", "initials": "CK"}, {"family": "Schultz", "given": "Marcus J", "initials": "MJ"}, {"family": "Storti", "given": "Enrico", "initials": "E"}, {"family": "Strange", "given": "Charlie", "initials": "C"}, {"family": "Thomson", "given": "Carey C", "initials": "CC"}, {"family": "Torriani", "given": "Francesca J", "initials": "FJ"}, {"family": "Wang", "given": "Xun", "initials": "X"}, {"family": "Wuyts", "given": "Wim", "initials": "W"}, {"family": "Xu", "given": "Tao", "initials": "T"}, {"family": "Yang", "given": "Dawei", "initials": "D"}, {"family": "Zhang", "given": "Ziqiang", "initials": "Z"}, {"family": "Wilson", "given": "Kevin C", "initials": "KC"}], "type": "journal article", "published": "2020-09-30", "journal": {"title": "Eur Respir Rev", "issn": "1600-0617", "volume": "29", "issue": "157", "issn-l": "0905-9180"}, "abstract": "Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome-coronavirus-2. Consensus suggestions can standardise care, thereby improving outcomes and facilitating future research.\n\nAn International Task Force was composed and agreement regarding courses of action was measured using the Convergence of Opinion on Recommendations and Evidence (CORE) process. 70% agreement was necessary to make a consensus suggestion.\n\nThe Task Force made consensus suggestions to treat patients with acute COVID-19 pneumonia with remdesivir and dexamethasone but suggested against hydroxychloroquine except in the context of a clinical trial; these are revisions of prior suggestions resulting from the interim publication of several randomised trials. It also suggested that COVID-19 patients with a venous thromboembolic event be treated with therapeutic anticoagulant therapy for 3 months. The Task Force was unable to reach sufficient agreement to yield consensus suggestions for the post-hospital care of COVID-19 survivors. The Task Force fell one vote shy of suggesting routine screening for depression, anxiety and post-traumatic stress disorder.\n\nThe Task Force addressed questions related to pharmacotherapy in patients with COVID-19 and the post-hospital care of survivors, yielding several consensus suggestions. Management options for which there is insufficient agreement to formulate a suggestion represent research priorities.", "doi": "10.1183/16000617.0287-2020", "pmid": "33020069", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "29/157/200287"}, {"db": "pmc", "key": "PMC7537943"}], "notes": [], "created": "2020-11-27T12:39:01.420Z", "modified": "2020-11-27T12:39:01.445Z"}, {"entity": "publication", "iuid": "2e68cc9fd8374ee184f801694fbe140c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e68cc9fd8374ee184f801694fbe140c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e68cc9fd8374ee184f801694fbe140c"}}, "title": "The major genetic risk factor for severe COVID-19 is inherited from Neanderthals.", "authors": [{"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "P\u00e4\u00e4bo", "given": "Svante", "initials": "S"}], "type": "journal article", "published": "2020-09-30", "journal": {"title": "Nature", "issn": "1476-4687", "issn-l": "0028-0836", "volume": "587", "issue": "7835", "pages": "610-612"}, "abstract": "A recent genetic association study 1 identified a gene cluster on chromosome 3 as a risk locus for respiratory failure after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A separate study (COVID-19 Host Genetics Initiative)2 comprising 3,199 hospitalized patients with coronavirus disease 2019 (COVID-19) and control individuals showed that this cluster is the major genetic risk factor for severe symptoms after SARS-CoV-2 infection and hospitalization. Here we show that the risk is conferred by a genomic segment of around 50 kilobases in size that is inherited from Neanderthals and is carried by around 50% of people in south Asia and around 16% of people in Europe.", "doi": "10.1038/s41586-020-2818-3", "pmid": "32998156", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41586-020-2818-3"}, {"db": "URL", "key": "http://genome.ucsc.edu/cgi-bin/hgTrackUi?db=hg38&g=covidHgiGwas", "description": "COVID-19 Host Genetics Initiative (round 3, ANA_B2_V2):  summary statistics of the genome-wide association study"}, {"db": "NA", "key": "Genetic information used in the study are available in public repositories (e.g. http://cdna.eva.mpg.de/neandertal/)", "description": null}], "notes": [], "created": "2020-11-18T17:00:53.715Z", "modified": "2021-11-18T09:10:47.724Z"}, {"entity": "publication", "iuid": "450e8ebbae3a45899766c71e26df149c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/450e8ebbae3a45899766c71e26df149c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/450e8ebbae3a45899766c71e26df149c"}}, "title": "Innate Immune Responses to Acute Viral Infection During Pregnancy.", "authors": [{"family": "Cornish", "given": "Emily F", "initials": "EF"}, {"family": "Filipovic", "given": "Iva", "initials": "I"}, {"family": "\u00c5senius", "given": "Fredrika", "initials": "F"}, {"family": "Williams", "given": "David J", "initials": "DJ"}, {"family": "McDonnell", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2020-09-30", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "11", "issue": null, "pages": "572567", "issn-l": "1664-3224"}, "abstract": "Immunological adaptations in pregnancy allow maternal tolerance of the semi-allogeneic fetus but also increase maternal susceptibility to infection. At implantation, the endometrial stroma, glands, arteries and immune cells undergo anatomical and functional transformation to create the decidua, the specialized secretory endometrium of pregnancy. The maternal decidua and the invading fetal trophoblast constitute a dynamic junction that facilitates a complex immunological dialogue between the two. The decidual and peripheral immune systems together assume a pivotal role in regulating the critical balance between tolerance and defense against infection. Throughout pregnancy, this equilibrium is repeatedly subjected to microbial challenge. Acute viral infection in pregnancy is associated with a wide spectrum of adverse consequences for both mother and fetus. Vertical transmission from mother to fetus can cause developmental anomalies, growth restriction, preterm birth and stillbirth, while the mother is predisposed to heightened morbidity and maternal death. A rapid, effective response to invasive pathogens is therefore essential in order to avoid overwhelming maternal infection and consequent fetal compromise. This sentinel response is mediated by the innate immune system: a heritable, highly evolutionarily conserved system comprising physical barriers, antimicrobial peptides (AMP) and a variety of immune cells-principally neutrophils, macrophages, dendritic cells, and natural killer cells-which express pattern-receptors that detect invariant molecular signatures unique to pathogenic micro-organisms. Recognition of these signatures during acute infection triggers signaling cascades that enhance antimicrobial properties such as phagocytosis, secretion of pro-inflammatory cytokines and activation of the complement system. As well as coordinating the initial immune response, macrophages and dendritic cells present microbial antigens to lymphocytes, initiating and influencing the development of specific, long-lasting adaptive immunity. Despite extensive progress in unraveling the immunological adaptations of pregnancy, pregnant women remain particularly susceptible to certain acute viral infections and continue to experience mortality rates equivalent to those observed in pandemics several decades ago. Here, we focus specifically on the pregnancy-induced vulnerabilities in innate immunity that contribute to the disproportionately high maternal mortality observed in the following acute viral infections: Lassa fever, Ebola virus disease (EVD), dengue fever, hepatitis E, influenza, and novel coronavirus infections.", "doi": "10.3389/fimmu.2020.572567", "pmid": "33101294", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7556209"}], "notes": [], "created": "2020-11-26T12:26:42.810Z", "modified": "2020-11-27T11:47:54.134Z"}, {"entity": "publication", "iuid": "7349e144370e444abab068898e378e7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7349e144370e444abab068898e378e7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7349e144370e444abab068898e378e7e"}}, "title": "Impact of Coronavirus Disease 2019 (COVID-19) Outbreak on Acute Admissions at the Emergency and Cardiology Departments Across Europe.", "authors": [{"family": "Sokolski", "given": "Mateusz", "initials": "M"}, {"family": "Gajewski", "given": "Piotr", "initials": "P"}, {"family": "Zymli\u0144ski", "given": "Robert", "initials": "R"}, {"family": "Biegus", "given": "Jan", "initials": "J"}, {"family": "Berg", "given": "Jurrien M Ten", "initials": "JMT"}, {"family": "Bor", "given": "Wilbert", "initials": "W"}, {"family": "Braunschweig", "given": "Frieder", "initials": "F"}, {"family": "Caldeira", "given": "Daniel", "initials": "D"}, {"family": "Cuculi", "given": "Florim", "initials": "F"}, {"family": "D'Elia", "given": "Emilia", "initials": "E"}, {"family": "Edes", "given": "Istvan Ferenc", "initials": "IF"}, {"family": "Garus", "given": "Mateusz", "initials": "M"}, {"family": "Greenwood", "given": "John P", "initials": "JP"}, {"family": "Halfwerk", "given": "Frank R", "initials": "FR"}, {"family": "Hindricks", "given": "Gerhard", "initials": "G"}, {"family": "Knuuti", "given": "Juhani", "initials": "J"}, {"family": "Kristensen", "given": "Steen Dalby", "initials": "SD"}, {"family": "Landmesser", "given": "Ulf", "initials": "U"}, {"family": "Lund", "given": "Lars H", "initials": "LH"}, {"family": "Lyon", "given": "Alexander", "initials": "A"}, {"family": "Mebazaa", "given": "Alexandre", "initials": "A"}, {"family": "Merkely", "given": "B\u00e9la", "initials": "B"}, {"family": "Nawrocka-Millward", "given": "Sylwia", "initials": "S"}, {"family": "Pinto", "given": "Fausto J", "initials": "FJ"}, {"family": "Ruschitzka", "given": "Frank", "initials": "F"}, {"family": "Semedo", "given": "Edimir", "initials": "E"}, {"family": "Senni", "given": "Michele", "initials": "M"}, {"family": "Sepehri Shamloo", "given": "Alireza", "initials": "A"}, {"family": "Sorensen", "given": "Jacob", "initials": "J"}, {"family": "Stengaard", "given": "Carsten", "initials": "C"}, {"family": "Thiele", "given": "Holger", "initials": "H"}, {"family": "Toggweiler", "given": "Stefan", "initials": "S"}, {"family": "Tukiendorf", "given": "Andrzej", "initials": "A"}, {"family": "Verhorst", "given": "Patrick M", "initials": "PM"}, {"family": "Wright", "given": "David Jay", "initials": "DJ"}, {"family": "Zamorano", "given": "Pepe", "initials": "P"}, {"family": "Zuber", "given": "Michel", "initials": "M"}, {"family": "Narula", "given": "Jagat", "initials": "J"}, {"family": "Bax", "given": "Jeroen J", "initials": "JJ"}, {"family": "Ponikowski", "given": "Piotr", "initials": "P"}], "type": "journal article", "published": "2020-09-30", "journal": {"title": "Am J Med", "issn": "1555-7162", "volume": null, "issue": null, "issn-l": null}, "abstract": "We evaluated whether the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) pandemic was associated with changes in the pattern of acute cardiovascular admissions across European centers.\n\nWe set-up a multicenter, multinational, pan-European observational registry in 15 centers from 12 countries. All consecutive acute admissions to emergency departments and cardiology departments throughout a 1-month period during the COVID-19 outbreak were compared with an equivalent 1-month period in 2019. The acute admissions to cardiology departments were classified into 5 major categories: acute coronary syndrome, acute heart failure, arrhythmia, pulmonary embolism, and other.\n\nData from 54,331 patients were collected and analyzed. Nine centers provided data on acute admissions to emergency departments comprising 50,384 patients: 20,226 in 2020 compared with 30,158 in 2019 (incidence rate ratio [IRR] with 95% confidence interval [95%CI]: 0.66 [0.58-0.76]). The risk of death at the emergency departments was higher in 2020 compared to 2019 (odds ratio [OR] with 95% CI: 4.1 [3.0-5.8], P < 0.0001). All 15 centers provided data on acute cardiology departments admissions: 3007 patients in 2020 and 4452 in 2019; IRR (95% CI): 0.68 (0.64-0.71). In 2020, there were fewer admissions with IRR (95% CI): acute coronary syndrome: 0.68 (0.63-0.73); acute heart failure: 0.65 (0.58-0.74); arrhythmia: 0.66 (0.60-0.72); and other: 0.68(0.62-0.76). We found a relatively higher percentage of pulmonary embolism admissions in 2020: odds ratio (95% CI): 1.5 (1.1-2.1), P = 0.02. Among patients with acute coronary syndrome, there were fewer admissions with unstable angina: 0.79 (0.66-0.94); non-ST segment elevation myocardial infarction: 0.56 (0.50-0.64); and ST-segment elevation myocardial infarction: 0.78 (0.68-0.89).\n\nIn the European centers during the COVID-19 outbreak, there were fewer acute cardiovascular admissions. Also, fewer patients were admitted to the emergency departments with 4 times higher death risk at the emergency departments.", "doi": "10.1016/j.amjmed.2020.08.043", "pmid": "33010226", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0002-9343(20)30825-1"}, {"db": "pmc", "key": "PMC7526639"}], "notes": [], "created": "2020-12-03T08:54:27.721Z", "modified": "2021-02-26T08:46:13.256Z"}, {"entity": "publication", "iuid": "55408eb290b74ff58a7e7ce77a376726", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/55408eb290b74ff58a7e7ce77a376726.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/55408eb290b74ff58a7e7ce77a376726"}}, "title": "Transitioning Between Online Gambling Modalities and Decrease in Total Gambling Activity, but No Indication of Increase in Problematic Online Gambling Intensity During the First Phase of the COVID-19 Outbreak in Sweden: A Time Series Forecast Study.", "authors": [{"family": "Lindner", "given": "Philip", "initials": "P"}, {"family": "Forsstr\u00f6m", "given": "David", "initials": "D"}, {"family": "Jonsson", "given": "Jakob", "initials": "J"}, {"family": "Berman", "given": "Anne H", "initials": "AH"}, {"family": "Carlbring", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2020-09-29", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "8", "issue": null, "pages": "554542"}, "abstract": "Introduction: The COVID-19 outbreak will likely have a public health impact beyond immediate disease transmission. Little is known about whether social distancing and other societal changes has provoked an increase in gambling, whether decreased betting opportunities due to paused sports events spurred gamblers to transition to online casino gambling, or whether any of these factors have had an impact on problem gambling. Methods: Data on lookup queries against the Swedish Gambling Paus registry, logging all initiated gambling sessions by all licensed gambling providers, from 2019-01-01 (start of registry) to 2020-04-08 (well into the first phase of the outbreak) were analyzed using TBATS time series forecasting to estimate trends after the first domestic COVID-19 death. Obfuscated data on daily total wagered and deposited amounts, split by modality (casino or betting, and low and high intensity, respectively) for the equivalent period were supplied by a licensed online gambling provider. Results: Total gambling activity decreased by 13.29% during the first phase of the outbreak compared to forecast. Analyses of online gambling data revealed that although betting decreased substantially in synchrony with a slight increase in online casino gambling, there was no increase in likely problematic, high-intensity gambling and neither did total online gambling increase. Conclusions: This first, preliminary study revealed no increase in Swedish gambling activity, total or specifically online, in the first phase of the COVID-19 outbreak. Future research should examine whether pandemic-induced transitioning between gambling modalities and/or increased participation in gambling, leads to long-term effects on prevalence of problem gambling.", "doi": "10.3389/fpubh.2020.554542", "pmid": "33117770", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7550730"}], "notes": [], "created": "2020-12-01T15:10:25.688Z", "modified": "2023-06-19T14:25:31.050Z"}, {"entity": "publication", "iuid": "252e6e3b499a4f00b054837e86a9f448", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/252e6e3b499a4f00b054837e86a9f448.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/252e6e3b499a4f00b054837e86a9f448"}}, "title": "Presence of SARS-CoV-2 in urine is rare and not associated with acute kidney injury in critically ill COVID-19 patients.", "authors": [{"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Bergqvist", "given": "Anders", "initials": "A"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2020-09-29", "journal": {"title": "Crit Care", "issn": "1466-609X", "issn-l": "1364-8535", "volume": "24", "issue": "1", "pages": "587"}, "abstract": null, "doi": "10.1186/s13054-020-03302-w", "pmid": "32993742", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-020-03302-w"}, {"db": "pmc", "key": "PMC7523248"}], "notes": [], "created": "2020-10-30T11:37:02.479Z", "modified": "2022-02-14T07:31:25.838Z"}, {"entity": "publication", "iuid": "4eb9d1599aef4d0d8d35c472a8e20ea9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4eb9d1599aef4d0d8d35c472a8e20ea9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4eb9d1599aef4d0d8d35c472a8e20ea9"}}, "title": "A common model for the breathlessness experience", "authors": [{"family": "Finnegan", "given": "Sarah L", "initials": "SL"}, {"family": "Pattinson", "given": "Kyle T S", "initials": "KTS"}, {"family": "Sundh", "given": "Josefin", "initials": "J"}, {"family": "Sk\u00f6ld", "given": "Magnus", "initials": "M"}, {"family": "Janson", "given": "Christer", "initials": "C"}, {"family": "Blomberg", "given": "Anders", "initials": "A"}, {"family": "Sandberg", "given": "Jacob", "initials": "J"}, {"family": "Ekstr\u00f6m", "given": "Magnus", "initials": "M"}], "type": "posted-content", "published": "2020-09-29", "journal": {"title": "", "issn": null, "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1101/2020.09.29.20203943", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-10T04:31:13.835Z", "modified": "2021-06-10T04:31:13.835Z"}, {"entity": "publication", "iuid": "5ed913f6997047d098f6186a54cff8bb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5ed913f6997047d098f6186a54cff8bb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5ed913f6997047d098f6186a54cff8bb"}}, "title": "MAIT cell activation and dynamics associated with COVID-19 disease severity.", "authors": [{"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Gorin", "given": "Jean-Baptiste", "initials": "J"}, {"family": "Ponzetta", "given": "Andrea", "initials": "A"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Kammann", "given": "Tobias", "initials": "T"}, {"family": "Emg\u00e5rd", "given": "Johanna", "initials": "J"}, {"family": "Perez-Potti", "given": "Andr\u00e9", "initials": "A"}, {"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Karolinska COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Folkesson", "given": "Elin", "initials": "E"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}], "type": "journal article", "published": "2020-09-28", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "issn-l": "2470-9468", "volume": "5", "issue": "51", "pages": null}, "abstract": "Severe COVID-19 is characterized by excessive inflammation of the lower airways. The balance of protective versus pathological immune responses in COVID-19 is incompletely understood. Mucosa-associated invariant T (MAIT) cells are antimicrobial T cells that recognize bacterial metabolites, and can also function as innate-like sensors and mediators of antiviral responses. Here, we investigated the MAIT cell compartment in COVID-19 patients with moderate and severe disease, as well as in convalescence. We show profound and preferential decline in MAIT cells in the circulation of patients with active disease paired with strong activation. Furthermore, transcriptomic analyses indicated significant MAIT cell enrichment and pro-inflammatory IL-17A bias in the airways. Unsupervised analysis identified MAIT cell CD69 high and CXCR3low immunotypes associated with poor clinical outcome. MAIT cell levels normalized in the convalescent phase, consistent with dynamic recruitment to the tissues and later release back into the circulation when disease is resolved. These findings indicate that MAIT cells are engaged in the immune response against SARS-CoV-2 and suggest their possible involvement in COVID-19 immunopathogenesis.", "doi": "10.1126/sciimmunol.abe1670", "pmid": "32989174", "labels": {"Type: Journal article": null, "Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Genomics & transcriptomics": null, "Category: Health": null, "Category: Proteins": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "URL", "key": "https://covid19cellatlas.com/#/", "description": "Curated flow cytometry data are available for exploration via the Karolinska COVID-19 Immune Atlas"}, {"db": "URL", "key": "https://www.science.org/doi/10.1126/sciimmunol.abe1670#", "description": "Raw data available in the supplementary materials"}], "notes": [], "created": "2020-10-28T09:05:35.876Z", "modified": "2021-11-18T08:57:57.308Z"}, {"entity": "publication", "iuid": "308f9d1f08cb40baba508a70b7f74083", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/308f9d1f08cb40baba508a70b7f74083.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/308f9d1f08cb40baba508a70b7f74083"}}, "title": "Characteristics and short-term obstetric outcomes in a case series of 67 women test-positive for SARS-CoV-2 in Stockholm, Sweden.", "authors": [{"family": "Remaeus", "given": "Katarina", "initials": "K"}, {"family": "Savchenko", "given": "Julia", "initials": "J"}, {"family": "Brismar Wendel", "given": "Sophia", "initials": "S"}, {"family": "Brusell Gidl\u00f6f", "given": "Sebastian", "initials": "S"}, {"family": "Graner", "given": "Sophie", "initials": "S"}, {"family": "Jones", "given": "Elin", "initials": "E"}, {"family": "Molin", "given": "Johanna", "initials": "J"}, {"family": "Saltvedt", "given": "Sissel", "initials": "S"}, {"family": "Wallstr\u00f6m", "given": "Tove", "initials": "T"}, {"family": "Pettersson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2020-09-27", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "12", "pages": "1626-1631", "issn-l": "0001-6349"}, "abstract": "The Stockholm region was the first area in Sweden to be hit by the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The national guidelines on the care of women with a positive test for SARS-CoV-2 (detection with polymerase chain reaction [PCR]) recommend individualized antenatal care, mode of delivery based on obstetric considerations, and no routine separation of the mother and the newborn. Breastfeeding is encouraged, and although there is no specific recommendation regarding wearing a face mask to prevent viral transmission to the newborn while nursing, instructions are given to keep high hygiene standards. All studies based on cases tested on hospital admission will capture more women with pregnancy complications than in the general population. Our aim was to describe the clinical characteristics of SARS-CoV-2-positive women and their neonates, and to report short-term maternal and neonatal outcomes.\n\nA retrospective case series with data from medical records including all test-positive women (n = 67) who gave birth to 68 neonates from 19 March to 26 April 2020 in Stockholm, Sweden. Means, proportions and percentages were calculated for clinical characteristics and outcomes.\n\nThe mean age was 32 years, 40% were nulliparous and 61% were overweight or obese. Further, 15% had diabetes and 21% a hypertensive disease. Seventy percent of the women had a vaginal birth. Preterm delivery occurred in 19% of the women. The preterm deliveries were mostly medically indicated, including two women who were delivered preterm due to severe coronavirus disease 19 (COVID-19), corresponding to 15% of the preterm births. Four women (6%) were admitted to the intensive care unit postpartum but there were no maternal deaths. There were two perinatal deaths (one stillbirth and one neonatal death). Three neonates were PCR-positive for SARS-CoV-2 after birth.\n\nIn this case series of 67 women testing positive for SARS-CoV-2 with clinical presentations ranging from asymptomatic to manifest COVID-19 disease, few women presented with severe COVID-19 illness. The majority had a vaginal birth at term with a healthy neonate that was negative for SARS-CoV-2.", "doi": "10.1111/aogs.14006", "pmid": "32981033", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7537005"}], "notes": [], "created": "2020-11-18T17:02:04.781Z", "modified": "2021-02-26T08:45:48.016Z"}, {"entity": "publication", "iuid": "9175d3585166411d81c584242c79bed8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9175d3585166411d81c584242c79bed8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9175d3585166411d81c584242c79bed8"}}, "title": "Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation.", "authors": [{"family": "Wallentin", "given": "Lars", "initials": "L"}, {"family": "Lindb\u00e4ck", "given": "Johan", "initials": "J"}, {"family": "Eriksson", "given": "Niclas", "initials": "N"}, {"family": "Hijazi", "given": "Ziad", "initials": "Z"}, {"family": "Eikelboom", "given": "John W", "initials": "JW"}, {"family": "Ezekowitz", "given": "Michael D", "initials": "MD"}, {"family": "Granger", "given": "Christopher B", "initials": "CB"}, {"family": "Lopes", "given": "Renato D", "initials": "RD"}, {"family": "Yusuf", "given": "Salim", "initials": "S"}, {"family": "Oldgren", "given": "Jonas", "initials": "J"}, {"family": "Siegbahn", "given": "Agneta", "initials": "A"}], "type": "journal article", "published": "2020-09-27", "journal": {"title": "Eur Heart J", "issn": "1522-9645", "volume": "41", "issue": "41", "pages": "4037-4046", "issn-l": "0195-668X"}, "abstract": "The global COVID-19 pandemic is caused by the SARS-CoV-2 virus entering human cells using angiotensin-converting enzyme 2 (ACE2) as a cell surface receptor. ACE2 is shed to the circulation, and a higher plasma level of soluble ACE2 (sACE2) might reflect a higher cellular expression of ACE2. The present study explored the associations between sACE2 and clinical factors, cardiovascular biomarkers, and genetic variability.\r\n\r\nPlasma and DNA samples were obtained from two international cohorts of elderly patients with atrial fibrillation (n = 3999 and n = 1088). The sACE2 protein level was measured by the Olink Proteomics\u00ae Multiplex CVD II96 \u00d7 96 panel. Levels of the biomarkers high-sensitive cardiac troponin T (hs-cTnT), N-terminal probrain natriuretic peptide (NT-proBNP), growth differentiation factor 15 (GDF-15), C-reactive protein, interleukin-6, D-dimer, and cystatin-C were determined by immunoassays. Genome-wide association studies were performed by Illumina chips. Higher levels of sACE2 were statistically significantly associated with male sex, cardiovascular disease, diabetes, and older age. The sACE2 level was most strongly associated with the levels of GDF-15, NT-proBNP, and hs-cTnT. When adjusting for these biomarkers, only male sex remained associated with sACE2. We found no statistically significant genetic regulation of the sACE2 level.\r\n\r\nMale sex and clinical or biomarker indicators of biological ageing, cardiovascular disease, and diabetes are associated with higher sACE2 levels. The levels of GDF-15 and NT-proBNP, which are associated both with the sACE2 level and a higher risk for mortality and cardiovascular disease, might contribute to better identification of risk for severe COVID-19 infection.", "doi": "10.1093/eurheartj/ehaa697", "pmid": "32984892", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "5912214"}, {"db": "pmc", "key": "PMC7543499"}], "notes": [], "created": "2020-11-17T18:09:17.932Z", "modified": "2021-02-26T08:45:48.463Z"}, {"entity": "publication", "iuid": "eb89850b924e4388a4b97ddead5e4fde", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb89850b924e4388a4b97ddead5e4fde.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb89850b924e4388a4b97ddead5e4fde"}}, "title": "Sex Differences in Reported Adverse Drug Reactions to COVID-19 Drugs in a Global Database of Individual Case Safety Reports.", "authors": [{"family": "Zekarias", "given": "Alem", "initials": "A"}, {"family": "Watson", "given": "Sarah", "initials": "S"}, {"family": "Vidlin", "given": "Sara Hedfors", "initials": "SH"}, {"family": "Grundmark", "given": "Birgitta", "initials": "B"}], "type": "journal article", "published": "2020-09-25", "journal": {"title": "Drug Saf", "issn": "1179-1942", "volume": "43", "issue": "12", "pages": "1309-1314", "issn-l": "0114-5916"}, "abstract": "In late 2019, a new coronavirus-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-was discovered in Wuhan, China, and the World Health Organization later declared coronavirus disease 2019 (COVID-19) a pandemic. Numerous drugs have been repurposed and investigated for therapeutic effectiveness in the disease, including those from \"Solidarity,\" an international clinical trial (azithromycin, chloroquine, hydroxychloroquine, the fixed combination lopinavir/ritonavir, and remdesivir).\n\nOur objective was to evaluate adverse drug reaction (ADR) reporting for drugs when used in the treatment of COVID-19 compared with use for other indications, specifically focussing on sex differences.\n\nWe extracted reports on COVID-19-specific treatments from the global ADR database, VigiBase, using an algorithm developed to identify reports that listed COVID-19 as the indication. The Solidarity trial drugs were included, as were any drugs reported \u2265 100 times. We performed a descriptive comparison of reports for the same drugs used in non-COVID-19 indications. The data lock point date was 7 June 2020.\n\nIn total, 2573 reports were identified for drugs used in the treatment of COVID-19. In order of frequency, the most reported ADRs were electrocardiogram QT-prolonged, diarrhoea, nausea, hepatitis, and vomiting in males and diarrhoea, electrocardiogram QT-prolonged, nausea, vomiting, and upper abdominal pain in females. Other hepatic and kidney-related events were included in the top ten ADRs in males, whereas no hepatic or renal terms were reported for females. COVID-19-related reporting patterns differed from non-pandemic reporting for these drugs.\n\nReview of a global database of suspected ADR reports revealed sex differences in the reporting patterns for drugs used in the treatment of COVID-19. Patterns of ADR sex differences need further elucidation.", "doi": "10.1007/s40264-020-01000-8", "pmid": "32978702", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40264-020-01000-8"}, {"db": "pmc", "key": "PMC7518652"}], "notes": [], "created": "2020-11-22T09:50:11.774Z", "modified": "2020-11-27T12:40:03.156Z"}, {"entity": "publication", "iuid": "3ecce14ec16245e3bf05acf13930cd8c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ecce14ec16245e3bf05acf13930cd8c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ecce14ec16245e3bf05acf13930cd8c"}}, "title": "Public awareness, emotional reactions and human mobility in response to the COVID-19 outbreak in China - a population-based ecological study.", "authors": [{"family": "Li", "given": "Yuchen", "initials": "Y"}, {"family": "Zeng", "given": "Yu", "initials": "Y"}, {"family": "Liu", "given": "Guangdi", "initials": "G"}, {"family": "Lu", "given": "Donghao", "initials": "D"}, {"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Qiu", "given": "Jianqing", "initials": "J"}, {"family": "Zhang", "given": "Chao", "initials": "C"}, {"family": "Fall", "given": "Katja", "initials": "K"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Zhang", "given": "Wei", "initials": "W"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "journal article", "published": "2020-09-25", "journal": {"title": "Psychol Med", "issn": "1469-8978", "volume": null, "issue": null, "pages": "1-8", "issn-l": "0033-2917"}, "abstract": "The outbreak of COVID-19 generated severe emotional reactions, and restricted mobility was a crucial measure to reduce the spread of the virus. This study describes the changes in public emotional reactions and mobility patterns in the Chinese population during the COVID-19 outbreak.\n\nWe collected data on public emotional reactions in response to the outbreak through Weibo, the Chinese Twitter, between 1st January and 31st March 2020. Using anonymized location-tracking information, we analyzed the daily mobility patterns of approximately 90% of Sichuan residents.\n\nThere were three distinct phases of the emotional and behavioral reactions to the COVID-19 outbreak. The alarm phase (19th-26th January) was a restriction-free period, characterized by few new daily cases, but a large amount public negative emotions [the number of negative comments per Weibo post increased by 246.9 per day, 95% confidence interval (CI) 122.5-371.3], and a substantial increase in self-limiting mobility (from 45.6% to 54.5%, changing by 1.5% per day, 95% CI 0.7%-2.3%). The epidemic phase (27th January-15th February) exhibited rapidly increasing numbers of new daily cases, decreasing expression of negative emotions (a decrease of 27.3 negative comments per post per day, 95% CI -40.4 to -14.2), and a stabilized level of self-limiting mobility. The relief phase (16th February-31st March) had a steady decline in new daily cases and decreasing levels of negative emotion and self-limiting mobility.\n\nDuring the COVID-19 outbreak in China, the public's emotional reaction was strongest before the actual peak of the outbreak and declined thereafter. The change in human mobility patterns occurred before the implementation of restriction orders, suggesting a possible link between emotion and behavior.", "doi": "10.1017/S003329172000375X", "pmid": "32972473", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S003329172000375X"}, {"db": "pmc", "key": "PMC7542325"}], "notes": [], "created": "2020-12-03T15:07:39.951Z", "modified": "2021-02-26T08:45:48.088Z"}, {"entity": "publication", "iuid": "43f6cc5c2db44f8d9539cdc08d15ddee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/43f6cc5c2db44f8d9539cdc08d15ddee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/43f6cc5c2db44f8d9539cdc08d15ddee"}}, "title": "Presence of hyaluronan in lung alveoli in severe Covid-19 - an opening for new treatment options?", "authors": [{"family": "Hellman", "given": "Urban", "initials": "U"}, {"family": "Karlsson", "given": "Mats G", "initials": "MG"}, {"family": "Engstr\u00f6m-Laurent", "given": "Anna", "initials": "A"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "Dorofte", "given": "Luiza", "initials": "L"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Laurent", "given": "Claude", "initials": "C"}, {"family": "Blomberg", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-09-25", "journal": {"title": "J Biol Chem", "issn": "1083-351X", "volume": "295", "issue": "45", "pages": "15418-15422", "issn-l": "0021-9258"}, "abstract": "Severe corona virus disease 2019 (Covid-19) is characterized by inflammation of the lungs with increasing respiratory impairment. In fatal Covid-19, lungs at autopsy have been filled with a clear liquid jelly. However, the nature of this finding has not yet been determined.The aim of the study was to demonstrate if the lungs of fatal Covid-19 contain hyaluronan as it is associated with inflammation and acute respiratory distress syndrome (ARDS) and may have the appearance of liquid jelly.Lung tissue obtained at autopsy from three deceased Covid-19 patients was processed for hyaluronan histochemistry using a direct staining method and compared with staining in normal lung tissue.Stainings confirmed that hyaluronan is obstructing alveoli with presence in exudate and plugs, as well as in thickened perialveolar interstitium. In contrast, normal lungs only showed hyaluronan in intact alveolar walls and perivascular tissue. This is the first study to confirm prominent hyaluronan exudates in the alveolar spaces of Covid-19 lungs, supporting the notion that the macromolecule is involved in ARDS caused by SARS-CoV-2. The present finding may open up for new treatment options in severe Covid-19, aiming at reducing the presence and production of hyaluronan in the lungs.", "doi": "10.1074/jbc.AC120.015967", "pmid": "32978255", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Imaging": null}, "xrefs": [{"db": "NA", "key": "Provided in the article: color light micrographs of autopsy lung tissue from the three Covid-19 cases", "description": null}], "notes": [], "created": "2020-10-28T09:07:27.329Z", "modified": "2021-02-26T08:45:36.597Z"}, {"entity": "publication", "iuid": "a61e49761bfe4a18b81bb94f09c05300", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a61e49761bfe4a18b81bb94f09c05300.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a61e49761bfe4a18b81bb94f09c05300"}}, "title": "Inactivation of SARS-CoV-2 and HCoV-229E in vitro by ColdZyme\u00ae a medical device mouth spray against the common cold.", "authors": [{"family": "Gudmundsdottir", "given": "\u00c1g\u00fasta", "initials": "\u00c1"}, {"family": "Scheving", "given": "Reynir", "initials": "R"}, {"family": "Lindberg", "given": "Fredrik", "initials": "F"}, {"family": "Stefansson", "given": "Bjarki", "initials": "B"}], "type": "journal article", "published": "2020-09-25", "journal": {"title": "J Med Virol", "issn": "1096-9071", "volume": null, "issue": null, "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic calls for effective and safe treatments. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 actively replicates in the throat, unlike SARS-CoV, and shows high pharyngeal viral shedding even in patients with mild symptoms of the disease. HCoV-229E is one of four coronaviruses causing the common cold. In this study, the efficacy of ColdZyme\u00ae (CZ-MD), a medical device mouth spray, was tested against SARS-CoV-2 and HCoV-229E in vitro. The CZ-MD provides a protective glycerol barrier containing cod trypsin as an ancillary component. Combined, these ingredients can inactivate common cold viruses in the throat and mouth. The CZ-MD is believed to act on the viral surface proteins that would perturb their entry pathway into cells. The efficacy and safety of the CZ-MD have been demonstrated in clinical trials on the common cold.\n\nThe ability of the CZ-MD to inactivate SARS-CoV-2 and HCoV-229E was tested using an in vitro virucidal suspension test (ASTM E1052).\n\nCZ-MD inactivated SARS-CoV-2 by 98.3% and HCoV-229E by 99.9%.\n\nCZ-MD mouth spray can inactivate the respiratory coronaviruses SARS-CoV-2 and HCoV-229E in vitro. Although the in vitro results presented cannot be directly translated into clinical efficacy, the study indicates that CZ-MD might offer a protective barrier against SARS-CoV-2 and a decreased risk of COVID-19 transmission.", "doi": "10.1002/jmv.26554", "pmid": "32975843", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7537187"}], "notes": [], "created": "2020-12-03T09:53:18.160Z", "modified": "2021-02-26T08:46:13.408Z"}, {"entity": "publication", "iuid": "f07eeb1d98f44403815c952ee55045c3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f07eeb1d98f44403815c952ee55045c3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f07eeb1d98f44403815c952ee55045c3"}}, "title": "Impact of COVID-19 on Online Gambling - A General Population Survey During the Pandemic.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-09-25", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "11", "issue": null, "pages": "568543"}, "abstract": "The COVID-19 pandemic may have severe impact on mental health, and concerns have been raised about potentially increased online behavior and possibly increased gambling problems, such as in sports bettors at risk of transfer to even riskier forms of gambling during sports lock-down. Given the need for objective data about gambling behavior during the pandemic, the present analysis, from a project assessing online gambling in Sweden, aimed to study past-30-day gambling patterns in online gamblers in Sweden. The study, carried out in May, 2020, during the pandemic and its restrictions on society, included past-year online gamblers ( N = 997). Past-30-day gambling for several gambling types was lower compared to a previous study in online gamblers in the same setting, while online non-sports gambling remained at high levels. Those reporting sports betting even during a period with decreased sports betting occasions proved to have markedly higher gambling problems. COVID-19 may alter gambling behaviors, and online gamblers who maintain or initiate gambling types theoretically reduced by the crisis may represent a group at particular risk.", "doi": "10.3389/fpsyg.2020.568543", "pmid": "33101137", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7546777"}], "notes": [], "created": "2020-12-01T15:26:58.330Z", "modified": "2022-11-10T06:23:11.417Z"}, {"entity": "publication", "iuid": "02f623854eac45c9a12385a468181dfb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02f623854eac45c9a12385a468181dfb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02f623854eac45c9a12385a468181dfb"}}, "title": "Using volunteered geographic information to assess mobility in the early phases of the COVID-19 pandemic: a cross-city time series analysis of 41 cities in 22 countries from March 2nd to 26th 2020.", "authors": [{"family": "Vannoni", "given": "Matia", "initials": "M"}, {"family": "McKee", "given": "Martin", "initials": "M"}, {"family": "Semenza", "given": "Jan C", "initials": "JC"}, {"family": "Bonell", "given": "Chris", "initials": "C"}, {"family": "Stuckler", "given": "David", "initials": "D"}], "type": "journal article", "published": "2020-09-23", "journal": {"title": "Global Health", "issn": "1744-8603", "issn-l": "1744-8603", "volume": "16", "issue": "1", "pages": "85"}, "abstract": "Restricting mobility is a central aim for lowering contact rates and preventing COVID-19 transmission. Yet the impact on mobility of different non-pharmaceutical countermeasures in the earlier stages of the pandemic is not well-understood.\r\n\r\nTrends were evaluated using Citymapper's mobility index covering 2nd to 26th March 2020, expressed as percentages of typical usage periods from 0% as the lowest and 100% as normal. China and India were not covered. Multivariate fixed effects models were used to estimate the association of policies restricting movement on mobility before and after their introduction. Policy restrictions were assessed using the Oxford COVID-19 Government Response Stringency Index as well as measures coding the timing and degree of school and workplace closures, transport restrictions, and cancellation of mass gatherings.\r\n\r\n41 cities worldwide.\r\n\r\nCitymapper's mobility index.\r\n\r\nMobility declined in all major cities throughout March. Larger declines were seen in European than Asian cities. The COVID-19 Government Response Stringency Index was strongly associated with declines in mobility (r = - 0.75, p < 0.001). After adjusting for time-trends, we observed that implementing non-pharmaceutical countermeasures was associated with a decline of mobility of 10.0% for school closures (95% CI: 4.36 to 15.7%), 15.0% for workplace closures (95% CI: 10.2 to 19.8%), 7.09% for cancelling public events (95% CI: 1.98 to 12.2%), 18.0% for closing public transport (95% CI: 6.74 to 29.2%), 13.3% for restricting internal movements (95% CI: 8.85 to 17.8%) and 5.30% for international travel controls (95% CI: 1.69 to 8.90). In contrast, as expected, there was no association between population mobility changes and fiscal or monetary measures or emergency healthcare investment.\r\n\r\nUnderstanding the effect of public policy on mobility in the early stages is crucial to slowing and reducing COVID-19 transmission. By using Citymapper's mobility index, this work provides the first evidence about trends in mobility and the impacts of different policy interventions, suggesting that closure of public transport, workplaces and schools are particularly impactful.", "doi": "10.1186/s12992-020-00598-9", "pmid": "32967691", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12992-020-00598-9"}, {"db": "pmc", "key": "PMC7509494"}], "notes": [], "created": "2020-12-03T15:10:35.960Z", "modified": "2022-11-10T06:24:31.850Z"}, {"entity": "publication", "iuid": "b5ca3e7c61b14b03b1d97ab34f663163", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5ca3e7c61b14b03b1d97ab34f663163.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5ca3e7c61b14b03b1d97ab34f663163"}}, "title": "Small droplet emission in exhaled breath during different breathing manoeuvres: Implications for clinical lung function testing during COVID-19.", "authors": [{"family": "Greening", "given": "Neil J", "initials": "NJ"}, {"family": "Larsson", "given": "Per", "initials": "P"}, {"family": "Ljungstr\u00f6m", "given": "Evert", "initials": "E"}, {"family": "Siddiqui", "given": "Salman", "initials": "S"}, {"family": "Olin", "given": "Anna-Carin", "initials": "AC"}], "type": "letter", "published": "2020-09-23", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": null, "issue": null, "issn-l": "0105-4538"}, "abstract": null, "doi": "10.1111/all.14596", "pmid": "32966612", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7537081"}], "notes": [], "created": "2020-12-03T09:05:39.572Z", "modified": "2020-12-03T09:05:39.584Z"}, {"entity": "publication", "iuid": "018d04d578e04e89989323730b746c3f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/018d04d578e04e89989323730b746c3f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/018d04d578e04e89989323730b746c3f"}}, "title": "Massive and rapid COVID-19 testing is feasible by extraction-free SARS-CoV-2 RT-PCR.", "authors": [{"family": "Smyrlaki", "given": "Ioanna", "initials": "I"}, {"family": "Ekman", "given": "Martin", "initials": "M"}, {"family": "Lentini", "given": "Antonio", "initials": "A", "orcid": "0000-0003-1239-5495", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8c1f3989ef84f6d9803fb30b3014dc4.json"}}, {"family": "Rufino de Sousa", "given": "Nuno", "initials": "N", "orcid": "0000-0002-0670-9788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1cb037a9e7f44a489dd84d6f5ba513d7.json"}}, {"family": "Papanicolaou", "given": "Natali", "initials": "N"}, {"family": "Vondracek", "given": "Martin", "initials": "M"}, {"family": "Aarum", "given": "Johan", "initials": "J"}, {"family": "Safari", "given": "Hamzah", "initials": "H"}, {"family": "Muradrasoli", "given": "Shaman", "initials": "S"}, {"family": "Rothfuchs", "given": "Antonio Gigliotti", "initials": "AG", "orcid": "0000-0001-6001-7240", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00102c49ae2d41828272e850cd551c9f.json"}}, {"family": "Albert", "given": "Jan", "initials": "J", "orcid": "0000-0001-9020-0521", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79a6c7eedadb4a1e8c6fd7b8b522a8e3.json"}}, {"family": "H\u00f6gberg", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0003-2715-7887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11deae9980bd4bf6859b25de2b0c3908.json"}}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-7021-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9eef54f4e0534805b173cfae62a75d55.json"}}], "type": "comparative study", "published": "2020-09-23", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "11", "issue": "1", "pages": "4812"}, "abstract": "Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is commonly diagnosed by reverse transcription polymerase chain reaction (RT-PCR) to detect viral RNA in patient samples, but RNA extraction constitutes a major bottleneck in current testing. Methodological simplification could increase diagnostic availability and efficiency, benefitting patient care and infection control. Here, we describe methods circumventing RNA extraction in COVID-19 testing by performing RT-PCR directly on heat-inactivated or lysed samples. Our data, including benchmarking using 597 clinical patient samples and a standardised diagnostic system, demonstrate that direct RT-PCR is viable option to extraction-based tests. Using controlled amounts of active SARS-CoV-2, we confirm effectiveness of heat inactivation by plaque assay and evaluate various generic buffers as transport medium for direct RT-PCR. Significant savings in time and cost are achieved through RNA-extraction-free protocols that are directly compatible with established PCR-based testing pipelines. This could aid expansion of COVID-19 testing.", "doi": "10.1038/s41467-020-18611-5", "pmid": "32968075", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Diagnostics for virus": null}, "xrefs": [{"db": "pmc", "key": "PMC7511968"}, {"db": "pii", "key": "10.1038/s41467-020-18611-5"}], "notes": [], "created": "2020-10-30T12:04:36.610Z", "modified": "2023-06-19T15:01:27.658Z"}, {"entity": "publication", "iuid": "c9df8b74343c4af8870f002b5a1f4c99", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9df8b74343c4af8870f002b5a1f4c99.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9df8b74343c4af8870f002b5a1f4c99"}}, "title": "Association of SARS-CoV-2 Test Status and Pregnancy Outcomes.", "authors": [{"family": "Ahlberg", "given": "Mia", "initials": "M"}, {"family": "Neovius", "given": "Martin", "initials": "M"}, {"family": "Saltvedt", "given": "Sissel", "initials": "S"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Pettersson", "given": "Karin", "initials": "K"}, {"family": "Brandkvist", "given": "Clara", "initials": "C"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}], "type": "journal article", "published": "2020-09-23", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484", "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1001/jama.2020.19124", "pmid": "32965467", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "2771110"}, {"db": "pmc", "key": "PMC7512127"}], "notes": [], "created": "2020-11-18T17:03:47.315Z", "modified": "2021-02-26T08:45:48.707Z"}, {"entity": "publication", "iuid": "209ab7dba5694ea6a03b0ca5ab24a397", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/209ab7dba5694ea6a03b0ca5ab24a397.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/209ab7dba5694ea6a03b0ca5ab24a397"}}, "title": "Psychosocial emergency care in times of COVID-19: the Essen University Hospital concept for corona-infected patients, their relatives, and medical staff.", "authors": [{"family": "Rentrop", "given": "Vanessa", "initials": "V"}, {"family": "Schneider", "given": "Johanna Sophie", "initials": "JS"}, {"family": "B\u00e4uerle", "given": "Alexander", "initials": "A"}, {"family": "Junne", "given": "Florian", "initials": "F"}, {"family": "D\u00f6rrie", "given": "Nora", "initials": "N"}, {"family": "Skoda", "given": "Eva-Maria", "initials": "E"}, {"family": "Schedlowski", "given": "Manfred", "initials": "M"}, {"family": "Mallmann", "given": "Bernhard", "initials": "B"}, {"family": "Benecke", "given": "Anke-Verena", "initials": "A"}, {"family": "Kohler", "given": "Hannah", "initials": "H"}, {"family": "Gerigk", "given": "Monja", "initials": "M"}, {"family": "Teigelack", "given": "Per", "initials": "P"}, {"family": "Emler", "given": "Tobias", "initials": "T"}, {"family": "Scherbaum", "given": "Norbert", "initials": "N"}, {"family": "Gradl-Dietsch", "given": "Gertraud", "initials": "G"}, {"family": "Scheer", "given": "Karin", "initials": "K"}, {"family": "Teufel", "given": "Martin", "initials": "M"}], "type": "letter", "published": "2020-09-22", "journal": {"title": "Int Arch Occup Environ Health", "issn": "1432-1246", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Due to the SARS CoV-2-virus (COVID-19), anxiety, distress, and insecurity occur more frequently. In particular, infected individuals, their relatives, and medical staff face an increased risk of high psychological distress as a result of the ongoing pandemic. Thus, structured psychosocial emergency concepts are needed. The University hospital of Essen has taken up this challenge by creating the PEC concept to reduce psychosocial long-term consequences for infected patients, relatives, and medical staff at the university hospital. The concept includes professional medical as well as psychological support to convey constructive coping strategies and the provision of adequate tools such as the low-threshold online training program (CoPE It), which is accessible via the webpage www.cope-corona.de .", "doi": "10.1007/s00420-020-01580-z", "pmid": "32964313", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00420-020-01580-z"}, {"db": "pmc", "key": "PMC7508238"}], "notes": [], "created": "2020-12-03T09:23:51.961Z", "modified": "2022-11-10T06:25:29.610Z"}, {"entity": "publication", "iuid": "94fad26a33554d9aa598c2b1d08311fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/94fad26a33554d9aa598c2b1d08311fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/94fad26a33554d9aa598c2b1d08311fd"}}, "title": "Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19.", "authors": [{"family": "Kanberg", "given": "Nelly", "initials": "N"}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Price", "given": "Richard W", "initials": "RW"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2020-09-22", "journal": {"title": "Neurology", "issn": "1526-632X", "volume": "95", "issue": "12", "pages": "e1754-e1759", "issn-l": "0028-3878"}, "abstract": "To test the hypothesis that coronavirus disease 2019 (COVID-19) has an impact on the CNS by measuring plasma biomarkers of CNS injury.\n\nWe recruited 47 patients with mild (n = 20), moderate (n = 9), or severe (n = 18) COVID-19 and measured 2 plasma biomarkers of CNS injury by single molecule array, neurofilament light chain protein (NfL; a marker of intra-axonal neuronal injury) and glial fibrillary acidic protein (GFAp; a marker of astrocytic activation/injury), in samples collected at presentation and again in a subset after a mean of 11.4 days. Cross-sectional results were compared with results from 33 age-matched controls derived from an independent cohort.\n\nThe patients with severe COVID-19 had higher plasma concentrations of GFAp ( p = 0.001) and NfL (p < 0.001) than controls, while GFAp was also increased in patients with moderate disease (p = 0.03). In patients with severe disease, an early peak in plasma GFAp decreased on follow-up (p < 0.01), while NfL showed a sustained increase from first to last follow-up (p < 0.01), perhaps reflecting a sequence of early astrocytic response and more delayed axonal injury.\n\nWe show neurochemical evidence of neuronal injury and glial activation in patients with moderate and severe COVID-19. Further studies are needed to clarify the frequency and nature of COVID-19-related CNS damage and its relation to both clinically defined CNS events such as hypoxic and ischemic events and mechanisms more closely linked to systemic severe acute respiratory syndrome coronavirus 2 infection and consequent immune activation, as well as to evaluate the clinical utility of monitoring plasma NfL and GFAp in the management of this group of patients.", "doi": "10.1212/WNL.0000000000010111", "pmid": "32546655", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "NA", "key": "Researchers can apply for access to anonymized data", "description": null}], "notes": [], "created": "2020-10-30T11:38:14.005Z", "modified": "2021-02-26T08:45:03.162Z"}, {"entity": "publication", "iuid": "7853c20a2ac34fef9a21a1b25175065a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7853c20a2ac34fef9a21a1b25175065a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7853c20a2ac34fef9a21a1b25175065a"}}, "title": "Mitigation of the replication of SARS-CoV-2 by nitric oxide in vitro", "authors": [{"family": "Akaberi", "given": "Dario", "initials": "D"}, {"family": "Krambrich", "given": "Janina", "initials": "J"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Luni", "given": "Chen", "initials": "C"}, {"family": "Hedenstierna", "given": "G\u00f6ran", "initials": "G"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}, {"family": "Lennerstrand", "given": "Johan", "initials": "J"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "journal-article", "published": "2020-09-21", "journal": {"title": "Redox Biology", "issn": "2213-2317", "issn-l": "2213-2317", "volume": "37", "issue": null, "pages": "101734"}, "abstract": "The ongoing SARS-CoV-2 pandemic is a global public health emergency posing a high burden on nations' health care systems and economies. Despite the great effort put in the development of vaccines and specific treatments, no prophylaxis or effective therapeutics are currently available. Nitric oxide (NO) is a broad-spectrum antimicrobial and a potent vasodilator that has proved to be effective in reducing SARS-CoV replication and hypoxia in patients with severe acute respiratory syndrome. Given the potential of NO as treatment for SARS-CoV-2 infection, we have evaluated the in vitro antiviral effect of NO on SARS-CoV-2 replication. The NO-donor S-nitroso-N-acetylpenicillamine (SNAP) had a dose dependent inhibitory effect on SARS-CoV-2 replication, while the non S-nitrosated NAP was not active, as expected. Although the viral replication was not completely abolished (at 200 \u03bcM and 400 \u03bcM), SNAP delayed or completely prevented the development of viral cytopathic effect in treated cells, and the observed protective effect correlated with the level of inhibition of the viral replication. The capacity of the NO released from SNAP to covalently bind and inhibit SARS-CoV-2 3CL recombinant protease in vitro was also tested. The observed reduction in SARS-CoV-2 protease activity was consistent with S-nitrosation of the enzyme active site cysteine.", "doi": "10.1016/j.redox.2020.101734", "pmid": "33007504", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Drug discovery and repurposing of drugs": null, "Category: Imaging": null, "Category: Proteins": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.1016/j.redox.2020.101734", "description": "Supplementary data"}], "notes": [], "created": "2020-10-30T11:25:59.730Z", "modified": "2021-06-14T14:31:10.633Z"}, {"entity": "publication", "iuid": "755e672d6e4b461c92ec69293c239cf2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/755e672d6e4b461c92ec69293c239cf2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/755e672d6e4b461c92ec69293c239cf2"}}, "title": "Crisis Management by Journal Editors: Case of COVID-19.", "authors": [{"family": "Sorooshian", "given": "Shahryar", "initials": "S"}], "type": "journal article", "published": "2020-09-21", "journal": {"title": "J Korean Med Sci", "issn": "1598-6357", "volume": "35", "issue": "37", "pages": "e320", "issn-l": null}, "abstract": null, "doi": "10.3346/jkms.2020.35.e320", "pmid": "32959545", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "35.e320"}, {"db": "pmc", "key": "PMC7505727"}], "notes": [], "created": "2020-12-03T09:25:25.650Z", "modified": "2020-12-03T09:25:25.675Z"}, {"entity": "publication", "iuid": "b8e24bc4dbf245908a5bf678a0c3b0b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8e24bc4dbf245908a5bf678a0c3b0b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8e24bc4dbf245908a5bf678a0c3b0b9"}}, "title": "Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test.", "authors": [{"family": "De Marinis", "given": "Yang", "initials": "Y"}, {"family": "Sunnerhagen", "given": "Torgny", "initials": "T"}, {"family": "Bompada", "given": "Pradeep", "initials": "P"}, {"family": "Bl\u00e4ckberg", "given": "Anna", "initials": "A"}, {"family": "Yang", "given": "Runtao", "initials": "R"}, {"family": "Svensson", "given": "Joel", "initials": "J"}, {"family": "Ekstr\u00f6m", "given": "Ola", "initials": "O"}, {"family": "Eriksson", "given": "Karl-Fredrik", "initials": "K"}, {"family": "Hansson", "given": "Ola", "initials": "O"}, {"family": "Groop", "given": "Leif", "initials": "L"}, {"family": "Gon\u00e7alves", "given": "Isabel", "initials": "I"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2020-09-20", "journal": {"title": "Infect Ecol Epidemiol", "issn": "2000-8686", "issn-l": "2000-8686", "volume": "10", "issue": "1", "pages": "1821513"}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has created a global health- and economic crisis. Detection of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19 by serological methods is important to diagnose a current or resolved infection. In this study, we applied a rapid COVID-19 IgM/IgG antibody test and performed serology assessment of antibody response to SARS-CoV-2. In PCR-confirmed COVID-19 patients (n = 45), the total antibody detection rate is 92% in hospitalized patients and 79% in non-hospitalized patients. The total IgM and IgG detection is 63% in patients with <2 weeks from disease onset; 85% in non-hospitalized patients with >2 weeks disease duration; and 91% in hospitalized patients with >2 weeks disease duration. We also compared different blood sample types and suggest a higher sensitivity by serum/plasma over whole blood. Test specificity was determined to be 97% on 69 sera/plasma samples collected between 2016-2018. Our study provides a comprehensive validation of the rapid COVID-19 IgM/IgG serology test, and mapped antibody detection patterns in association with disease progress and hospitalization. Our results support that the rapid COVID-19 IgM/IgG test may be applied to assess the COVID-19 status both at the individual and at a population level.", "doi": "10.1080/20008686.2020.1821513", "pmid": "33062217", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Serology": null}, "xrefs": [{"db": "pii", "key": "1821513"}, {"db": "pmc", "key": "PMC7534290"}], "notes": [], "created": "2020-12-01T17:09:23.638Z", "modified": "2021-02-26T08:46:49.378Z"}, {"entity": "publication", "iuid": "b1f90548f04e4b07a655403478429adf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1f90548f04e4b07a655403478429adf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1f90548f04e4b07a655403478429adf"}}, "title": "COVID-19 healthcare demand and mortality in Sweden in response to non-pharmaceutical mitigation and suppression scenarios.", "authors": [{"family": "Sj\u00f6din", "given": "Henrik", "initials": "H"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}, {"family": "Br\u00e4nnstr\u00f6m", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Farooq", "given": "Zia", "initials": "Z"}, {"family": "Kriit", "given": "Hedi Katre", "initials": "HK"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "\u00c5str\u00f6m", "given": "Christofer", "initials": "C"}, {"family": "Thunberg", "given": "Johan", "initials": "J"}, {"family": "S\u00f6derquist", "given": "M\u00e5rten", "initials": "M"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}], "type": "journal article", "published": "2020-09-20", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "issn-l": "0300-5771", "volume": "49", "issue": "5", "pages": "1443-1453"}, "abstract": "While the COVID-19 outbreak in China now appears suppressed, Europe and the USA have become the epicentres, both reporting many more deaths than China. Responding to the pandemic, Sweden has taken a different approach aiming to mitigate, not suppress, community transmission, by using physical distancing without lockdowns. Here we contrast the consequences of different responses to COVID-19 within Sweden, the resulting demand for care, intensive care, the death tolls and the associated direct healthcare related costs.\r\n\r\nWe used an age-stratified health-care demand extended SEIR (susceptible, exposed, infectious, recovered) compartmental model for all municipalities in Sweden, and a radiation model for describing inter-municipality mobility. The model was calibrated against data from municipalities in the Stockholm healthcare region.\r\n\r\nOur scenario with moderate to strong physical distancing describes well the observed health demand and deaths in Sweden up to the end of May 2020. In this scenario, the intensive care unit (ICU) demand reaches the pre-pandemic maximum capacity just above 500 beds. In the counterfactual scenario, the ICU demand is estimated to reach \u223c20 times higher than the pre-pandemic ICU capacity. The different scenarios show quite different death tolls up to 1 September, ranging from 5000 to 41 000, excluding deaths potentially caused by ICU shortage. Additionally, our statistical analysis of all causes excess mortality indicates that the number of deaths attributable to COVID-19 could be increased by 40% (95% confidence interval: 0.24, 0.57).\r\n\r\nThe results of this study highlight the impact of different combinations of non-pharmaceutical interventions, especially moderate physical distancing in combination with more effective isolation of infectious individuals, on reducing deaths, health demands and lowering healthcare costs. In less effective mitigation scenarios, the demand on ICU beds would rapidly exceed capacity, showing the tight interconnection between the healthcare demand and physical distancing in the society. These findings have relevance for Swedish policy and response to the COVID-19 pandemic and illustrate the importance of maintaining the level of physical distancing for a longer period beyond the study period to suppress or mitigate the impacts from the pandemic.", "doi": "10.1093/ije/dyaa121", "pmid": "32954400", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "5909271"}, {"db": "pmc", "key": "PMC7543571"}], "notes": [], "created": "2020-12-03T09:31:56.254Z", "modified": "2022-11-10T06:27:58.330Z"}, {"entity": "publication", "iuid": "865012848aa3469da99c9e119fb80623", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/865012848aa3469da99c9e119fb80623.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/865012848aa3469da99c9e119fb80623"}}, "title": "COVID Isolation Eating Scale (CIES): Analysis of the impact of confinement in eating disorders and obesity-A collaborative international study.", "authors": [{"family": "Fern\u00e1ndez-Aranda", "given": "Fernando", "initials": "F"}, {"family": "Mungu\u00eda", "given": "Lucero", "initials": "L"}, {"family": "Mestre-Bach", "given": "Gemma", "initials": "G"}, {"family": "Steward", "given": "Trevor", "initials": "T"}, {"family": "Etxandi", "given": "Mikel", "initials": "M"}, {"family": "Baenas", "given": "Isabel", "initials": "I"}, {"family": "Granero", "given": "Roser", "initials": "R"}, {"family": "S\u00e1nchez", "given": "Isabel", "initials": "I"}, {"family": "Ortega", "given": "Emilio", "initials": "E"}, {"family": "Andreu", "given": "Alba", "initials": "A"}, {"family": "Moize", "given": "Violeta L", "initials": "VL"}, {"family": "Fern\u00e1ndez-Real", "given": "Jose M", "initials": "JM"}, {"family": "Tinahones", "given": "Francisco J", "initials": "FJ"}, {"family": "Dieg\u00fcez", "given": "Carlos", "initials": "C"}, {"family": "Fr\u00fchbeck", "given": "Gema", "initials": "G"}, {"family": "Le Grange", "given": "Daniel", "initials": "D"}, {"family": "Tchanturia", "given": "Kate", "initials": "K"}, {"family": "Karwautz", "given": "Andreas", "initials": "A"}, {"family": "Zeiler", "given": "Michael", "initials": "M"}, {"family": "Favaro", "given": "Angela", "initials": "A"}, {"family": "Claes", "given": "Laurence", "initials": "L"}, {"family": "Luyckx", "given": "Koen", "initials": "K"}, {"family": "Shekriladze", "given": "Ia", "initials": "I"}, {"family": "Serrano-Troncoso", "given": "Eduardo", "initials": "E"}, {"family": "Rangil", "given": "Teresa", "initials": "T"}, {"family": "Meler", "given": "Maria Eulalia Loran", "initials": "MEL"}, {"family": "Soriano-Pacheco", "given": "Jose", "initials": "J"}, {"family": "Carceller-Sindreu", "given": "Mar", "initials": "M"}, {"family": "Bujalance-Arguijo", "given": "Sara", "initials": "S"}, {"family": "Lozano", "given": "Meritxell", "initials": "M"}, {"family": "Linares", "given": "Raquel", "initials": "R"}, {"family": "Gudiol", "given": "Carlota", "initials": "C"}, {"family": "Carratala", "given": "Jordi", "initials": "J"}, {"family": "Sanchez-Gonzalez", "given": "Jessica", "initials": "J"}, {"family": "Machado", "given": "Paulo Pp", "initials": "PP"}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "T\u00fary", "given": "Ferenc", "initials": "F"}, {"family": "P\u00e1szthy", "given": "Bea", "initials": "B"}, {"family": "Stein", "given": "Daniel", "initials": "D"}, {"family": "Papezov\u00e1", "given": "Hana", "initials": "H"}, {"family": "Bax", "given": "Brigita", "initials": "B"}, {"family": "Borisenkov", "given": "Mikhail F", "initials": "MF"}, {"family": "Popov", "given": "Sergey V", "initials": "SV"}, {"family": "Kim", "given": "Youl-Ri", "initials": "YR"}, {"family": "Nakazato", "given": "Michiko", "initials": "M"}, {"family": "Godart", "given": "Nathalie", "initials": "N"}, {"family": "van Voren", "given": "Robert", "initials": "R"}, {"family": "Ilnytska", "given": "Tetiana", "initials": "T"}, {"family": "Chen", "given": "Jue", "initials": "J"}, {"family": "Rowlands", "given": "Katie", "initials": "K"}, {"family": "Treasure", "given": "Janet", "initials": "J"}, {"family": "Jim\u00e9nez-Murcia", "given": "Susana", "initials": "S"}], "type": "journal article", "published": "2020-09-20", "journal": {"title": "Eur Eat Disord Rev", "issn": "1099-0968", "volume": null, "issue": null, "issn-l": null}, "abstract": "Confinement during the COVID-19 pandemic is expected to have a serious and complex impact on the mental health of patients with an eating disorder (ED) and of patients with obesity. The present manuscript has the following aims: (1) to analyse the psychometric properties of the COVID Isolation Eating Scale (CIES), (2) to explore changes that occurred due to confinement in eating symptomatology; and (3) to explore the general acceptation of the use of telemedicine during confinement. The sample comprised 121 participants (87 ED patients and 34 patients with obesity) recruited from six different centres. Confirmatory Factor Analyses (CFA) tested the rational-theoretical structure of the CIES. Adequate goodness-of-fit was obtained for the confirmatory factor analysis, and Cronbach alpha values ranged from good to excellent. Regarding the effects of confinement, positive and negative impacts of the confinement depends of the eating disorder subtype. Patients with anorexia nervosa (AN) and with obesity endorsed a positive response to treatment during confinement, no significant changes were found in bulimia nervosa (BN) patients, whereas Other Specified Feeding or Eating Disorder (OSFED) patients endorsed an increase in eating symptomatology and in psychopathology. Furthermore, AN patients expressed the greatest dissatisfaction and accommodation difficulty with remote therapy when compared with the previously provided face-to-face therapy. The present study provides empirical evidence on the psychometric robustness of the CIES tool and shows that a negative confinement impact was associated with ED subtype, whereas OSFED patients showed the highest impairment in eating symptomatology and in psychopathology.", "doi": "10.1002/erv.2784", "pmid": "32954595", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7537123"}], "notes": [], "created": "2020-12-03T09:30:37.325Z", "modified": "2020-12-03T09:30:37.348Z"}, {"entity": "publication", "iuid": "dcbf0bc0b92644a78d80a9dc708e6f34", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dcbf0bc0b92644a78d80a9dc708e6f34.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dcbf0bc0b92644a78d80a9dc708e6f34"}}, "title": "Sex differences in severity and mortality from COVID-19: are males more vulnerable?", "authors": [{"family": "Pradhan", "given": "Ajay", "initials": "A"}, {"family": "Olsson", "given": "Per-Erik", "initials": "PE"}], "type": "journal article", "published": "2020-09-18", "journal": {"title": "Biol Sex Differ", "issn": "2042-6410", "volume": "11", "issue": "1", "pages": "53", "issn-l": "2042-6410"}, "abstract": "Coronavirus disease 2019 (COVID-19) has shown high infection and mortality rates all over the world, and despite the global efforts, there is so far no specific therapy available for COVID-19. Interestingly, while the severity and mortality of COVID-19 are higher in males than in females, the underlying molecular mechanisms are unclear. In this review, we explore sex-related differences that may be contributing factors to the observed male-biased mortality from COVID-19. Males are considered the weaker sex in aspects related to endurance and infection control. Studies show that viral RNA clearance is delayed in males with COVID-19. A recent study has indicated that the testis can harbor coronavirus, and consequently, males show delayed viral clearance. However, the role of testis involvement in COVID-19 severity and mortality needs further research. Males and females show a distinct difference in immune system responses with females eliciting stronger immune responses to pathogens. This difference in immune system responses may be a major contributing factor to viral load, disease severity, and mortality. In addition, differences in sex hormone milieus could also be a determinant of viral infections as estrogen has immunoenhancing effects while testosterone has immunosuppressive effects. The sex-specific severity of COVID-19 infections indicates that further research on understanding the sex differences is needed. Inclusion of both males and females in basic research and clinical trials is required to provide critical information on sex-related differences that may help to better understand disease outcome and therapy.", "doi": "10.1186/s13293-020-00330-7", "pmid": "32948238", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13293-020-00330-7"}, {"db": "pmc", "key": "PMC7498997"}], "notes": [], "created": "2020-11-27T12:42:10.704Z", "modified": "2020-12-03T15:25:40.954Z"}, {"entity": "publication", "iuid": "17096ef2059d48928978ad8b31f503c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/17096ef2059d48928978ad8b31f503c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/17096ef2059d48928978ad8b31f503c5"}}, "title": "Death associated with coronavirus (COVID-19) infection in individuals with severe mental disorders in Sweden during the early months of the outbreak \u2013 a exploratory cross-sectional analysis of a population-based register study", "authors": [{"family": "Maripuu", "given": "Martin", "initials": "M", "orcid": "0000-0001-7868-8894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f85873e152d421eba74e23054d0ff1e.json"}}, {"family": "Bendix", "given": "Marie", "initials": "M", "orcid": "0000-0001-8901-166X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bbc1ba16f8c54e4e98e833c7066cf410.json"}}, {"family": "\u00d6hlund", "given": "Louise", "initials": "L", "orcid": "0000-0001-8271-5058", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c5008f4a48142269efb983389b805d0.json"}}, {"family": "Widerstr\u00f6m", "given": "Micael", "initials": "M", "orcid": "0000-0002-1483-4255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ad36fa63a334e3b91499527bb6d5659.json"}}, {"family": "Werneke", "given": "Ursula", "initials": "U", "orcid": "0000-0002-5023-3254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eed3b002ddb4cbba141cbfdc8d3f032.json"}}], "type": "posted-content", "published": "2020-09-18", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.09.14.20193987", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-14T06:40:14.574Z", "modified": "2022-11-22T05:52:46.830Z"}, {"entity": "publication", "iuid": "18b57d426c8641fa8ffe2f8ea572a873", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18b57d426c8641fa8ffe2f8ea572a873.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18b57d426c8641fa8ffe2f8ea572a873"}}, "title": "Community knowledge, perceptions and practices around COVID-19 in Sierra Leone: a nationwide, cross-sectional survey.", "authors": [{"family": "Sengeh", "given": "Paul", "initials": "P"}, {"family": "Jalloh", "given": "Mohammad B", "initials": "MB"}, {"family": "Webber", "given": "Nance", "initials": "N"}, {"family": "Ngobeh", "given": "Ibrahim", "initials": "I"}, {"family": "Samba", "given": "Thomas", "initials": "T"}, {"family": "Thomas", "given": "Harold", "initials": "H"}, {"family": "Nordenstedt", "given": "Helena", "initials": "H"}, {"family": "Winters", "given": "Maike", "initials": "M"}], "type": "journal article", "published": "2020-09-17", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "10", "issue": "9", "pages": "e040328"}, "abstract": "To assess the public's knowledge, attitudes and practices about the novel coronavirus in Sierra Leone to inform an evidence-based communication strategy around COVID-19.\r\n\r\nNationwide, cross-sectional Knowledge, Attitudes and Practices survey.\r\n\r\n56 randomly selected communities in all 14 districts in Sierra Leone.\r\n\r\n1253 adults aged 18 years and older of which 52% were men.\r\n\r\nWe calculated proportions of core indicators (awareness, knowledge, risk perception, practices). A composite variable for knowledge (based on seven variables) was created, and categorised into low (0-2 correct), medium (3-4) and high (5-7). Predictors of knowledge were analysed with multilevel ordinal regression models. Associations between information sources, knowledge and two practices (washing hands with soap and avoiding crowds) were analysed using multilevel logistic regression models.\r\n\r\nWe found that 75% of the respondents felt at moderate or great risk of contracting coronavirus. A majority (70%) of women did not know you can survive COVID-19, compared with 61% of men. 60% of men and 54% of women had already taken action to avoid infection with the coronavirus, mostly washing hands with soap and water (87%). Radio (73%) was the most used source for COVID-19 information, followed by social media (39%). Having a medium or high level of knowledge was associated with higher odds of washing hands with soap (medium knowledge: adjusted OR (AOR) 2.1, 95% CI 1.0 to 4.4; high knowledge: AOR 4.6, 95% CI 2.1 to 10.2) and avoiding crowds (medium knowledge: AOR 2.0, 95% CI 1.1 to 3.6; high knowledge: AOR 2.3, 95% CI 1.2 to 4.3).\r\n\r\nThis study shows that in the context of COVID-19 in Sierra Leone, there is a strong association between knowledge and practices. Because the knowledge gap differs between genders, regions, educational levels and age, it is important that messages are specifically targeted to these core audiences.", "doi": "10.1136/bmjopen-2020-040328", "pmid": "32948576", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-040328"}, {"db": "pmc", "key": "PMC7500298"}], "notes": [], "created": "2020-12-03T15:25:05.492Z", "modified": "2022-11-10T06:29:42.518Z"}, {"entity": "publication", "iuid": "5dc281be97ab40e09602086957f75065", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5dc281be97ab40e09602086957f75065.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5dc281be97ab40e09602086957f75065"}}, "title": "Randomized elimination and prolongation of ACE inhibitors and ARBs in coronavirus 2019 (REPLACE COVID) Trial Protocol.", "authors": [{"family": "Cohen", "given": "Jordana B", "initials": "JB"}, {"family": "Hanff", "given": "Thomas C", "initials": "TC"}, {"family": "Corrales-Medina", "given": "Vicente", "initials": "V"}, {"family": "William", "given": "Preethi", "initials": "P"}, {"family": "Renna", "given": "Nicolas", "initials": "N"}, {"family": "Rosado-Santander", "given": "Nelson R", "initials": "NR"}, {"family": "Rodriguez-Mori", "given": "Juan E", "initials": "JE"}, {"family": "Spaak", "given": "Jonas", "initials": "J"}, {"family": "Andrade-Villanueva", "given": "Jaime", "initials": "J"}, {"family": "Chang", "given": "Tara I", "initials": "TI"}, {"family": "Barbagelata", "given": "Alejandro", "initials": "A"}, {"family": "Alfonso", "given": "Carlos E", "initials": "CE"}, {"family": "Bernales-Salas", "given": "Eduardo", "initials": "E"}, {"family": "Coacalla", "given": "Johanna", "initials": "J"}, {"family": "Castro-Callirgos", "given": "Carlos Augusto", "initials": "CA"}, {"family": "Tupayachi-Venero", "given": "Karen E", "initials": "KE"}, {"family": "Medina", "given": "Carola", "initials": "C"}, {"family": "Valdivia", "given": "Renzo", "initials": "R"}, {"family": "Villavicencio", "given": "Mirko", "initials": "M"}, {"family": "Vasquez", "given": "Charles R", "initials": "CR"}, {"family": "Harhay", "given": "Michael O", "initials": "MO"}, {"family": "Chittams", "given": "Jesse", "initials": "J"}, {"family": "Sharkoski", "given": "Tiffany", "initials": "T"}, {"family": "Byrd", "given": "James Brian", "initials": "JB"}, {"family": "Edmonston", "given": "Daniel L", "initials": "DL"}, {"family": "Sweitzer", "given": "Nancy", "initials": "N"}, {"family": "Chirinos", "given": "Julio A", "initials": "JA"}], "type": "journal article", "published": "2020-09-16", "journal": {"title": "J Clin Hypertens (Greenwich)", "issn": "1751-7176", "volume": null, "issue": null, "issn-l": "1524-6175"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), is associated with high incidence of multiorgan dysfunction and death. Angiotensin-converting enzyme 2 (ACE2), which facilitates SARS-CoV-2 host cell entry, may be impacted by angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), two commonly used antihypertensive classes. In a multicenter, international randomized controlled trial that began enrollment on March 31, 2020, participants are randomized to continuation vs withdrawal of their long-term outpatient ACEI or ARB upon hospitalization with COVID-19. The primary outcome is a hierarchical global rank score incorporating time to death, duration of mechanical ventilation, duration of renal replacement or vasopressor therapy, and multiorgan dysfunction severity. Approval for the study has been obtained from the Institutional Review Board of each participating institution, and all participants will provide informed consent. A data safety monitoring board has been assembled to provide independent oversight of the project.", "doi": "10.1111/jch.14011", "pmid": "32937008", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-26T14:07:07.090Z", "modified": "2020-11-27T12:42:14.575Z"}, {"entity": "publication", "iuid": "1b3238e3b30b41ffb504a180899ff5d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b3238e3b30b41ffb504a180899ff5d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b3238e3b30b41ffb504a180899ff5d9"}}, "title": "Correction to: Psychometric Validation of the Bangla Fear of COVID-19 Scale: Confirmatory Factor Analysis and Rasch Analysis.", "authors": [{"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA"}], "type": "journal article", "published": "2020-09-16", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "volume": null, "issue": null, "pages": "1-3", "issn-l": null}, "abstract": null, "doi": "10.1007/s11469-020-00399-6", "pmid": "32958998", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "399"}, {"db": "pmc", "key": "PMC7493694"}], "notes": [], "created": "2020-12-03T09:28:53.598Z", "modified": "2020-12-03T09:28:53.611Z"}, {"entity": "publication", "iuid": "36ef7db8e3064cca91e3a0646b84fbb5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/36ef7db8e3064cca91e3a0646b84fbb5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/36ef7db8e3064cca91e3a0646b84fbb5"}}, "title": "Estimating the impact of mobility patterns on COVID-19 infection rates in 11 European countries.", "authors": [{"family": "Bryant", "given": "Patrick", "initials": "P"}, {"family": "Elofsson", "given": "Arne", "initials": "A"}], "type": "journal article", "published": "2020-09-15", "journal": {"title": "PeerJ", "issn": "2167-8359", "issn-l": "2167-8359", "volume": "8", "issue": null, "pages": "e9879"}, "abstract": "As governments across Europe have issued non-pharmaceutical interventions (NPIs) such as social distancing and school closing, the mobility patterns in these countries have changed. Most states have implemented similar NPIs at similar time points. However, it is likely different countries and populations respond differently to the NPIs and that these differences cause mobility patterns and thereby the epidemic development to change.\r\n\r\nWe build a Bayesian model that estimates the number of deaths on a given day dependent on changes in the basic reproductive number, R0, due to differences in mobility patterns. We utilise mobility data from Google mobility reports using five different categories: retail and recreation, grocery and pharmacy, transit stations, workplace and residential. The importance of each mobility category for predicting changes in R0 is estimated through the model.\r\n\r\nThe changes in mobility have a considerable overlap with the introduction of governmental NPIs, highlighting the importance of government action for population behavioural change. The shift in mobility in all categories shows high correlations with the death rates 1 month later. Reduction of movement within the grocery and pharmacy sector is estimated to account for most of the decrease in R0.\r\n\r\nOur model predicts 3-week epidemic forecasts, using real-time observations of changes in mobility patterns, which can provide governments with direct feedback on the effects of their NPIs. The model predicts the changes in a majority of the countries accurately but overestimates the impact of NPIs in Sweden and Denmark and underestimates them in France and Belgium. We also note that the exponential nature of all epidemiological models based on the basic reproductive number, R0 cause small errors to have extensive effects on the predicted outcome.", "doi": "10.7717/peerj.9879", "pmid": "32983643", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://github.com/patrickbryant1/COVID19.github.io/tree/master/simulations/mobility", "description": "Modelling code and data"}], "notes": [], "created": "2020-10-30T12:05:16.028Z", "modified": "2021-02-26T08:45:48.044Z"}, {"entity": "publication", "iuid": "b5b2d03702cc482b86707ae25d5fac83", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5b2d03702cc482b86707ae25d5fac83.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5b2d03702cc482b86707ae25d5fac83"}}, "title": "Cloth Masks May Prevent Transmission of COVID-19: An Evidence-Based, Risk-Based Approach.", "authors": [{"family": "Clase", "given": "Catherine M", "initials": "CM"}, {"family": "Fu", "given": "Edouard L", "initials": "EL"}, {"family": "Joseph", "given": "Meera", "initials": "M"}, {"family": "Beale", "given": "Rupert C L", "initials": "RCL"}, {"family": "Dolovich", "given": "Myrna B", "initials": "MB"}, {"family": "Jardine", "given": "Meg", "initials": "M"}, {"family": "Mann", "given": "Johannes F E", "initials": "JFE"}, {"family": "Pecoits-Filho", "given": "Roberto", "initials": "R"}, {"family": "Winkelmayer", "given": "Wolfgang C", "initials": "WC"}, {"family": "Carrero", "given": "Juan J", "initials": "JJ"}], "type": "editorial", "published": "2020-09-15", "journal": {"title": "Ann Intern Med", "issn": "1539-3704", "volume": "173", "issue": "6", "pages": "489-491", "issn-l": "0003-4819"}, "abstract": null, "doi": "10.7326/M20-2567", "pmid": "32441991", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7277485"}], "notes": [], "created": "2020-11-25T09:12:11.027Z", "modified": "2020-12-09T11:33:38.890Z"}, {"entity": "publication", "iuid": "142a4622975548cca4f4ddbb2bfbcc1c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/142a4622975548cca4f4ddbb2bfbcc1c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/142a4622975548cca4f4ddbb2bfbcc1c"}}, "title": "Spatio-Temporal Mutational Profile Appearances of Swedish SARS-CoV-2 during the Early Pandemic.", "authors": [{"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Hickman", "given": "Rachel A", "initials": "RA"}, {"family": "Li", "given": "Jinlin", "initials": "J"}, {"family": "Lu", "given": "Xi", "initials": "X"}, {"family": "Lindahl", "given": "Johanna F", "initials": "JF"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}], "type": "journal article", "published": "2020-09-14", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "12", "issue": "9", "pages": null}, "abstract": "During the COVID-19 pandemic, the virus evolved, and we therefore aimed to provide an insight into which genetic variants were enriched, and how they spread in Sweden.\r\n\r\nWe analyzed 348 Swedish SARS-CoV-2 sequences freely available from GISAID obtained from 7 February 2020 until 14 May 2020.\r\n\r\nWe identified 14 variant sites \u22655% frequency in the population. Among those sites, the D936Y substitution in the viral Spike protein was under positive selection. The variant sites can distinguish 11 mutational profiles in Sweden. Nine of the profiles appeared in Stockholm in March 2020. Mutational profiles 3 (B.1.1) and 6 (B.1), which contain the D936Y mutation, became the predominant profiles over time, spreading from Stockholm to other Swedish regions during April and the beginning of May. Furthermore, Bayesian phylogenetic analysis indicated that SARS-CoV-2 could have emerged in Sweden on 27 December 2019, and community transmission started on February 1st with an evolutionary rate of 1.5425 \u00d7 10 -3 substitutions per year.\r\n\r\nOur study provides novel knowledge on the spatio-temporal dynamics of Swedish SARS-CoV-2 variants during the early pandemic. Characterization of these viral variants can provide precious insights on viral pathogenesis and can be valuable for diagnostic and drug development approaches.", "doi": "10.3390/v12091026", "pmid": "32937868", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Drug discovery and repurposing of drugs": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "http://www.mdpi.com/1999-4915/12/9/1026/s1", "description": "Spatial temporal appearance of each variant and their mutation profile and clade information; Other supplementary materials."}], "notes": [], "created": "2020-10-28T09:08:27.508Z", "modified": "2021-06-13T14:21:08.152Z"}, {"entity": "publication", "iuid": "383eab77f1844350b33ce8258212261e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/383eab77f1844350b33ce8258212261e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/383eab77f1844350b33ce8258212261e"}}, "title": "Psychological Distress and Problem Gambling in Elite Athletes during COVID-19 Restrictions-A Web Survey in Top Leagues of Three Sports during the Pandemic.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "J\u00f6nsson", "given": "Caroline", "initials": "C"}, {"family": "Kentt\u00e4", "given": "G\u00f6ran", "initials": "G"}], "type": "journal article", "published": "2020-09-14", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "18", "pages": null}, "abstract": "COVID-19 and lockdown strategies may affect mental health and addictive behavior differently in the population, and elite athletes are among the professions clearly affected by the pandemic. This study in top elite athletes aimed to study current perceived psychological influence from COVID-19 and symptoms of depression, anxiety and changes in alcohol drinking, gambling behavior and problem gambling in the midst of the COVID-19 lockdown. This web survey included athletes in top leagues of soccer, ice hockey and handball in Sweden (N = 327, 62% men). A total of 66% and 51% were worried about the future of their sport or about their own future in sports, respectively. Feeling worse psychologically during the pandemic was common (72% of women, 40% of men, p < 0.001); depression criteria were endorsed by 19% of women and three percent of men (p < 0.001); anxiety criteria by 20% of women and five percent of men (p < 0.001). Reporting increased gambling during the pandemic was associated with gambling problem severity. Moderate-risk or problem gambling was seen in 10% of men and none of the women (p < 0.001). Depression and anxiety were associated with feeling worse during the COVID-19 pandemic and with concern over one's own sports future. In conclusion, COVID-19-related distress is common in elite athletes and associated with mental health symptoms. Gambling increase during the pandemic was rare, but related to gambling problems, which were common in male athletes. The calls for increased focus on COVID-19-related concerns in athletes and on problem gambling in male athletes.", "doi": "10.3390/ijerph17186693", "pmid": "32937978", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "ijerph17186693"}, {"db": "pmc", "key": "PMC7559357"}], "notes": [], "created": "2020-12-03T15:31:15.752Z", "modified": "2022-11-10T06:31:52.371Z"}, {"entity": "publication", "iuid": "6186d266f41a4cd995e5edb8ec12c8fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6186d266f41a4cd995e5edb8ec12c8fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6186d266f41a4cd995e5edb8ec12c8fd"}}, "title": "Pandemic programming: How COVID-19 affects software developers and how their organizations can help.", "authors": [{"family": "Ralph", "given": "Paul", "initials": "P"}, {"family": "Baltes", "given": "Sebastian", "initials": "S"}, {"family": "Adisaputri", "given": "Gianisa", "initials": "G"}, {"family": "Torkar", "given": "Richard", "initials": "R"}, {"family": "Kovalenko", "given": "Vladimir", "initials": "V"}, {"family": "Kalinowski", "given": "Marcos", "initials": "M"}, {"family": "Novielli", "given": "Nicole", "initials": "N"}, {"family": "Yoo", "given": "Shin", "initials": "S"}, {"family": "Devroey", "given": "Xavier", "initials": "X"}, {"family": "Tan", "given": "Xin", "initials": "X"}, {"family": "Zhou", "given": "Minghui", "initials": "M"}, {"family": "Turhan", "given": "Burak", "initials": "B"}, {"family": "Hoda", "given": "Rashina", "initials": "R"}, {"family": "Hata", "given": "Hideaki", "initials": "H"}, {"family": "Robles", "given": "Gregorio", "initials": "G"}, {"family": "Milani Fard", "given": "Amin", "initials": "A"}, {"family": "Alkadhi", "given": "Rana", "initials": "R"}], "type": "journal article", "published": "2020-09-14", "journal": {"title": "Empir Softw Eng", "issn": "1573-7616", "volume": null, "issue": null, "pages": "1-35", "issn-l": null}, "abstract": "As a novel coronavirus swept the world in early 2020, thousands of software developers began working from home. Many did so on short notice, under difficult and stressful conditions.\n\nThis study investigates the effects of the pandemic on developers' wellbeing and productivity.\n\nA questionnaire survey was created mainly from existing, validated scales and translated into 12 languages. The data was analyzed using non-parametric inferential statistics and structural equation modeling.\n\nThe questionnaire received 2225 usable responses from 53 countries. Factor analysis supported the validity of the scales and the structural model achieved a good fit (CFI = 0.961, RMSEA = 0.051, SRMR = 0.067). Confirmatory results include: (1) the pandemic has had a negative effect on developers' wellbeing and productivity; (2) productivity and wellbeing are closely related; (3) disaster preparedness, fear related to the pandemic and home office ergonomics all affect wellbeing or productivity. Exploratory analysis suggests that: (1) women, parents and people with disabilities may be disproportionately affected; (2) different people need different kinds of support.\n\nTo improve employee productivity, software companies should focus on maximizing employee wellbeing and improving the ergonomics of employees' home offices. Women, parents and disabled persons may require extra support.", "doi": "10.1007/s10664-020-09875-y", "pmid": "32952438", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "9875"}, {"db": "pmc", "key": "PMC7489196"}], "notes": [], "created": "2020-12-03T09:33:26.473Z", "modified": "2020-12-03T15:24:20.243Z"}, {"entity": "publication", "iuid": "0b5aef6454014621b5298e639210e0c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b5aef6454014621b5298e639210e0c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b5aef6454014621b5298e639210e0c9"}}, "title": "Shedding of infectious SARS-CoV-2 from airways in hospitalized COVID-19 patients in relation to serum antibody responses", "authors": [{"family": "Glans", "given": "Hedvig", "initials": "H"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Olausson", "given": "Mikaela", "initials": "M"}, {"family": "Falck-Jones", "given": "Sara", "initials": "S"}, {"family": "Varnaite", "given": "Renata", "initials": "R"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Lind Karlberg", "given": "Maria", "initials": "M"}, {"family": "Broddesson", "given": "Sandra", "initials": "S"}, {"family": "Falck-Jones", "given": "Ryan", "initials": "R"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Farnert", "given": "Anna", "initials": "A"}, {"family": "Smed Sorensen", "given": "Anna", "initials": "A"}, {"family": "Klingstrom", "given": "Jonas", "initials": "J"}, {"family": "Brave", "given": "Andreas", "initials": "A"}], "type": "posted-content", "published": "2020-09-13", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "issn-l": null, "volume": "21", "issue": "1", "pages": "494"}, "abstract": "To understand the risk of transmission of SARS-CoV-2 in hospitalized COVID-19 patients we simultaneously assessed the presence of SARS-CoV-2 RNA, live infectious virus in the airways, and virus-specific IgG and neutralizing antibodies in sera in 36 hospitalized COVID-19 patients. SARS-CoV-2 could be cultured from four patients, all with low or undetectable antibody response. Our data suggests that the level of SARS-CoV-2 antibodies may correlate to risk for shedding live SARS-CoV-2 virus in hospitalized COVID-19 patients.", "doi": "10.1186/s12879-021-06202-8", "pmid": "34044758", "labels": {"Funder: VR": null, "Category: Genomics & transcriptomics": null, "Category: Health": null, "Type: Journal article": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [], "notes": [], "created": "2020-10-29T12:35:34.869Z", "modified": "2021-11-18T08:50:56.330Z"}, {"entity": "publication", "iuid": "732dbf77b4de4598938e1ad6efc93392", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/732dbf77b4de4598938e1ad6efc93392.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/732dbf77b4de4598938e1ad6efc93392"}}, "title": "Guidance for the Management of Patients with Vascular Disease or Cardiovascular Risk Factors and COVID-19: Position Paper from VAS-European Independent Foundation in Angiology/Vascular Medicine.", "authors": [{"family": "Gerotziafas", "given": "Grigoris T", "initials": "GT"}, {"family": "Catalano", "given": "Mariella", "initials": "M"}, {"family": "Colgan", "given": "Mary-Paula", "initials": "MP"}, {"family": "Pecsvarady", "given": "Zsolt", "initials": "Z"}, {"family": "Wautrecht", "given": "Jean Claude", "initials": "JC"}, {"family": "Fazeli", "given": "Bahare", "initials": "B"}, {"family": "Olinic", "given": "Dan-Mircea", "initials": "DM"}, {"family": "Farkas", "given": "Katalin", "initials": "K"}, {"family": "Elalamy", "given": "Ismail", "initials": "I"}, {"family": "Falanga", "given": "Anna", "initials": "A"}, {"family": "Fareed", "given": "Jawed", "initials": "J"}, {"family": "Papageorgiou", "given": "Chryssa", "initials": "C"}, {"family": "Arellano", "given": "Rosella S", "initials": "RS"}, {"family": "Agathagelou", "given": "Petros", "initials": "P"}, {"family": "Antic", "given": "Darco", "initials": "D"}, {"family": "Auad", "given": "Luciana", "initials": "L"}, {"family": "Banfic", "given": "Ljiljana", "initials": "L"}, {"family": "Bartolomew", "given": "John R", "initials": "JR"}, {"family": "Benczur", "given": "Bela", "initials": "B"}, {"family": "Bernardo", "given": "Melissa B", "initials": "MB"}, {"family": "Boccardo", "given": "Francesco", "initials": "F"}, {"family": "Cifkova", "given": "Renate", "initials": "R"}, {"family": "Cosmi", "given": "Benilde", "initials": "B"}, {"family": "De Marchi", "given": "Sergio", "initials": "S"}, {"family": "Dimakakos", "given": "Evangelos", "initials": "E"}, {"family": "Dimopoulos", "given": "Meletios A", "initials": "MA"}, {"family": "Dimitrov", "given": "Gabriel", "initials": "G"}, {"family": "Durand-Zaleski", "given": "Isabelle", "initials": "I"}, {"family": "Edmonds", "given": "Michael", "initials": "M"}, {"family": "El Nazar", "given": "Essam Abo", "initials": "EA"}, {"family": "Erer", "given": "Dilek", "initials": "D"}, {"family": "Esponda", "given": "Omar L", "initials": "OL"}, {"family": "Gresele", "given": "Paolo", "initials": "P"}, {"family": "Gschwandtner", "given": "Michael", "initials": "M"}, {"family": "Gu", "given": "Yongquan", "initials": "Y"}, {"family": "Heinzmann", "given": "M\u00f3nica", "initials": "M"}, {"family": "Hamburg", "given": "Naomi M", "initials": "NM"}, {"family": "Hamad\u00e9", "given": "Amer", "initials": "A"}, {"family": "Jatoi", "given": "Noor-Ahmed", "initials": "NA"}, {"family": "Karahan", "given": "Oguz", "initials": "O"}, {"family": "Karetova", "given": "Debora", "initials": "D"}, {"family": "Karplus", "given": "Thomas", "initials": "T"}, {"family": "Klein-Weigel", "given": "Peter", "initials": "P"}, {"family": "Kolossvary", "given": "Endre", "initials": "E"}, {"family": "Kozak", "given": "Matija", "initials": "M"}, {"family": "Lefkou", "given": "Eleftheria", "initials": "E"}, {"family": "Lessiani", "given": "Gianfranco", "initials": "G"}, {"family": "Liew", "given": "Aaron", "initials": "A"}, {"family": "Marcoccia", "given": "Antonella", "initials": "A"}, {"family": "Marshang", "given": "Peter", "initials": "P"}, {"family": "Marakomichelakis", "given": "George", "initials": "G"}, {"family": "Matuska", "given": "Jiri", "initials": "J"}, {"family": "Moraglia", "given": "Luc", "initials": "L"}, {"family": "Pillon", "given": "Sergio", "initials": "S"}, {"family": "Poredos", "given": "Pavel", "initials": "P"}, {"family": "Prior", "given": "Manlio", "initials": "M"}, {"family": "Salvador", "given": "David Raymund K", "initials": "DRK"}, {"family": "Schlager", "given": "Oliver", "initials": "O"}, {"family": "Schernthaner", "given": "Gerit", "initials": "G"}, {"family": "Sieron", "given": "Alexander", "initials": "A"}, {"family": "Spaak", "given": "Jonas", "initials": "J"}, {"family": "Spyropoulos", "given": "Alex", "initials": "A"}, {"family": "Sprynger", "given": "Muriel", "initials": "M"}, {"family": "Suput", "given": "Dusan", "initials": "D"}, {"family": "Stanek", "given": "Agata", "initials": "A"}, {"family": "Stvrtinova", "given": "Viera", "initials": "V"}, {"family": "Szuba", "given": "Andrzej", "initials": "A"}, {"family": "Tafur", "given": "Alfonso", "initials": "A"}, {"family": "Vandreden", "given": "Patrick", "initials": "P"}, {"family": "Vardas", "given": "Panagiotis E", "initials": "PE"}, {"family": "Vasic", "given": "Dragan", "initials": "D"}, {"family": "Vikkula", "given": "Miikka", "initials": "M"}, {"family": "Wennberg", "given": "Paul", "initials": "P"}, {"family": "Zhai", "given": "Zhenguo", "initials": "Z"}, {"family": "Scientific Reviewer Committee", "given": "", "initials": ""}], "type": "journal article", "published": "2020-09-13", "journal": {"title": "Thromb Haemost", "issn": "2567-689X", "volume": null, "issue": null, "issn-l": "0340-6245"}, "abstract": "COVID-19 is also manifested with hypercoagulability, pulmonary intravascular coagulation, microangiopathy, and venous thromboembolism (VTE) or arterial thrombosis. Predisposing risk factors to severe COVID-19 are male sex, underlying cardiovascular disease, or cardiovascular risk factors including noncontrolled diabetes mellitus or arterial hypertension, obesity, and advanced age. The VAS-European Independent Foundation in Angiology/Vascular Medicine draws attention to patients with vascular disease (VD) and presents an integral strategy for the management of patients with VD or cardiovascular risk factors (VD-CVR) and COVID-19. VAS recommends (1) a COVID-19-oriented primary health care network for patients with VD-CVR for identification of patients with VD-CVR in the community and patients' education for disease symptoms, use of eHealth technology, adherence to the antithrombotic and vascular regulating treatments, and (2) close medical follow-up for efficacious control of VD progression and prompt application of physical and social distancing measures in case of new epidemic waves. For patients with VD-CVR who receive home treatment for COVID-19, VAS recommends assessment for (1) disease worsening risk and prioritized hospitalization of those at high risk and (2) VTE risk assessment and thromboprophylaxis with rivaroxaban, betrixaban, or low-molecular-weight heparin (LMWH) for those at high risk. For hospitalized patients with VD-CVR and COVID-19, VAS recommends (1) routine thromboprophylaxis with weight-adjusted intermediate doses of LMWH (unless contraindication); (2) LMWH as the drug of choice over unfractionated heparin or direct oral anticoagulants for the treatment of VTE or hypercoagulability; (3) careful evaluation of the risk for disease worsening and prompt application of targeted antiviral or convalescence treatments; (4) monitoring of D-dimer for optimization of the antithrombotic treatment; and (5) evaluation of the risk of VTE before hospital discharge using the IMPROVE-D-dimer score and prolonged post-discharge thromboprophylaxis with rivaroxaban, betrixaban, or LMWH.", "doi": "10.1055/s-0040-1715798", "pmid": "32920811", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-03T15:37:40.375Z", "modified": "2020-12-03T15:38:41.229Z"}, {"entity": "publication", "iuid": "87e3177a4f144265bc03fab88fd9a870", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87e3177a4f144265bc03fab88fd9a870.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87e3177a4f144265bc03fab88fd9a870"}}, "title": "Zoonotic Diseases: Etiology, Impact, and Control.", "authors": [{"family": "Rahman", "given": "Md Tanvir", "initials": "MT"}, {"family": "Sobur", "given": "Md Abdus", "initials": "MA"}, {"family": "Islam", "given": "Md Saiful", "initials": "MS"}, {"family": "Ievy", "given": "Samina", "initials": "S"}, {"family": "Hossain", "given": "Md Jannat", "initials": "MJ"}, {"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME"}, {"family": "Rahman", "given": "Amm Taufiquer", "initials": "AT"}, {"family": "Ashour", "given": "Hossam M", "initials": "HM"}], "type": "journal article", "published": "2020-09-12", "journal": {"title": "Microorganisms", "issn": "2076-2607", "volume": "8", "issue": "9", "pages": null, "issn-l": "2076-2607"}, "abstract": "Most humans are in contact with animals in a way or another. A zoonotic disease is a disease or infection that can be transmitted naturally from vertebrate animals to humans or from humans to vertebrate animals. More than 60% of human pathogens are zoonotic in origin. This includes a wide variety of bacteria, viruses, fungi, protozoa, parasites, and other pathogens. Factors such as climate change, urbanization, animal migration and trade, travel and tourism, vector biology, anthropogenic factors, and natural factors have greatly influenced the emergence, re-emergence, distribution, and patterns of zoonoses. As time goes on, there are more emerging and re-emerging zoonotic diseases. In this review, we reviewed the etiology of major zoonotic diseases, their impact on human health, and control measures for better management. We also highlighted COVID-19, a newly emerging zoonotic disease of likely bat origin that has affected millions of humans along with devastating global consequences. The implementation of One Health measures is highly recommended for the effective prevention and control of possible zoonosis.", "doi": "10.3390/microorganisms8091405", "pmid": "32932606", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "microorganisms8091405"}, {"db": "pmc", "key": "PMC7563794"}], "notes": [], "created": "2020-11-22T09:35:07.748Z", "modified": "2020-12-03T15:33:04.091Z"}, {"entity": "publication", "iuid": "cea2db86142e40b78905aca930630de3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cea2db86142e40b78905aca930630de3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cea2db86142e40b78905aca930630de3"}}, "title": "Response to the Novel Corona Virus (COVID-19) Pandemic Across Africa: Successes, Challenges, and Implications for the Future.", "authors": [{"family": "Ogunleye", "given": "Olayinka O", "initials": "OO"}, {"family": "Basu", "given": "Debashis", "initials": "D"}, {"family": "Mueller", "given": "Debjani", "initials": "D"}, {"family": "Sneddon", "given": "Jacqueline", "initials": "J"}, {"family": "Seaton", "given": "R Andrew", "initials": "RA"}, {"family": "Yinka-Ogunleye", "given": "Adesola F", "initials": "AF"}, {"family": "Wamboga", "given": "Joshua", "initials": "J"}, {"family": "Miljkovi\u0107", "given": "Nenad", "initials": "N"}, {"family": "Mwita", "given": "Julius C", "initials": "JC"}, {"family": "Rwegerera", "given": "Godfrey Mutashambara", "initials": "GM"}, {"family": "Massele", "given": "Amos", "initials": "A"}, {"family": "Patrick", "given": "Okwen", "initials": "O"}, {"family": "Niba", "given": "Loveline Lum", "initials": "LL"}, {"family": "Nsaikila", "given": "Melaine", "initials": "M"}, {"family": "Rashed", "given": "Wafaa M", "initials": "WM"}, {"family": "Hussein", "given": "Mohamed Ali", "initials": "MA"}, {"family": "Hegazy", "given": "Rehab", "initials": "R"}, {"family": "Amu", "given": "Adefolarin A", "initials": "AA"}, {"family": "Boahen-Boaten", "given": "Baffour Boaten", "initials": "BB"}, {"family": "Matsebula", "given": "Zinhle", "initials": "Z"}, {"family": "Gwebu", "given": "Prudence", "initials": "P"}, {"family": "Chirigo", "given": "Bongani", "initials": "B"}, {"family": "Mkhabela", "given": "Nongabisa", "initials": "N"}, {"family": "Dlamini", "given": "Tenelisiwe", "initials": "T"}, {"family": "Sithole", "given": "Siphiwe", "initials": "S"}, {"family": "Malaza", "given": "Sandile", "initials": "S"}, {"family": "Dlamini", "given": "Sikhumbuzo", "initials": "S"}, {"family": "Afriyie", "given": "Daniel", "initials": "D"}, {"family": "Asare", "given": "George Awuku", "initials": "GA"}, {"family": "Amponsah", "given": "Seth Kwabena", "initials": "SK"}, {"family": "Sefah", "given": "Israel", "initials": "I"}, {"family": "Oluka", "given": "Margaret", "initials": "M"}, {"family": "Guantai", "given": "Anastasia N", "initials": "AN"}, {"family": "Opanga", "given": "Sylvia A", "initials": "SA"}, {"family": "Sarele", "given": "Tebello Violet", "initials": "TV"}, {"family": "Mafisa", "given": "Refeletse Keabetsoe", "initials": "RK"}, {"family": "Chikowe", "given": "Ibrahim", "initials": "I"}, {"family": "Khuluza", "given": "Felix", "initials": "F"}, {"family": "Kibuule", "given": "Dan", "initials": "D"}, {"family": "Kalemeera", "given": "Francis", "initials": "F"}, {"family": "Mubita", "given": "Mwangana", "initials": "M"}, {"family": "Fadare", "given": "Joseph", "initials": "J"}, {"family": "Sibomana", "given": "Laurien", "initials": "L"}, {"family": "Ramokgopa", "given": "Gwendoline Malegwale", "initials": "GM"}, {"family": "Whyte", "given": "Carmen", "initials": "C"}, {"family": "Maimela", "given": "Tshegofatso", "initials": "T"}, {"family": "Hugo", "given": "Johannes", "initials": "J"}, {"family": "Meyer", "given": "Johanna C", "initials": "JC"}, {"family": "Schellack", "given": "Natalie", "initials": "N"}, {"family": "Rampamba", "given": "Enos M", "initials": "EM"}, {"family": "Visser", "given": "Adel", "initials": "A"}, {"family": "Alfadl", "given": "Abubakr", "initials": "A"}, {"family": "Malik", "given": "Elfatih M", "initials": "EM"}, {"family": "Malande", "given": "Oliver Ombeva", "initials": "OO"}, {"family": "Kalungia", "given": "Aubrey C", "initials": "AC"}, {"family": "Mwila", "given": "Chiluba", "initials": "C"}, {"family": "Zaranyika", "given": "Trust", "initials": "T"}, {"family": "Chaibva", "given": "Blessmore Vimbai", "initials": "BV"}, {"family": "Olaru", "given": "Ioana D", "initials": "ID"}, {"family": "Masuka", "given": "Nyasha", "initials": "N"}, {"family": "Wale", "given": "Janney", "initials": "J"}, {"family": "Hwenda", "given": "Lenias", "initials": "L"}, {"family": "Kamoga", "given": "Regina", "initials": "R"}, {"family": "Hill", "given": "Ruaraidh", "initials": "R"}, {"family": "Barbui", "given": "Corrado", "initials": "C"}, {"family": "Bochenek", "given": "Tomasz", "initials": "T"}, {"family": "Kurdi", "given": "Amanj", "initials": "A"}, {"family": "Campbell", "given": "Stephen", "initials": "S"}, {"family": "Martin", "given": "Antony P", "initials": "AP"}, {"family": "Phuong", "given": "Thuy Nguyen Thi", "initials": "TNT"}, {"family": "Thanh", "given": "Binh Nguyen", "initials": "BN"}, {"family": "Godman", "given": "Brian", "initials": "B"}], "type": "journal article", "published": "2020-09-11", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "11", "issue": null, "pages": "1205", "issn-l": "1663-9812"}, "abstract": "The COVID-19 pandemic has already claimed considerable lives. There are major concerns in Africa due to existing high prevalence rates for both infectious and non-infectious diseases and limited resources in terms of personnel, beds and equipment. Alongside this, concerns that lockdown and other measures will have on prevention and management of other infectious diseases and non-communicable diseases (NCDs). NCDs are an increasing issue with rising morbidity and mortality rates. The World Health Organization (WHO) warns that a lack of nets and treatment could result in up to 18 million additional cases of malaria and up to 30,000 additional deaths in sub-Saharan Africa.\n\nDocument current prevalence and mortality rates from COVID-19 alongside economic and other measures to reduce its spread and impact across Africa. In addition, suggested ways forward among all key stakeholder groups.\n\nContextualise the findings from a wide range of publications including internet-based publications coupled with input from senior-level personnel.\n\nPrevalence and mortality rates are currently lower in Africa than among several Western countries and the USA. This could be due to a number of factors including early instigation of lockdown and border closures, the younger age of the population, lack of robust reporting systems and as yet unidentified genetic and other factors. Innovation is accelerating to address concerns with available equipment. There are ongoing steps to address the level of misinformation and its consequences including fines. There are also ongoing initiatives across Africa to start addressing the unintended consequences of COVID-19 activities including lockdown measures and their impact on NCDs including the likely rise in mental health disorders, exacerbated by increasing stigma associated with COVID-19. Strategies include extending prescription lengths, telemedicine and encouraging vaccination. However, these need to be accelerated to prevent increased morbidity and mortality.\n\nThere are multiple activities across Africa to reduce the spread of COVID-19 and address misinformation, which can have catastrophic consequences, assisted by the WHO and others, which appear to be working in a number of countries. Research is ongoing to clarify the unintended consequences given ongoing concerns to guide future activities. Countries are learning from each other.", "doi": "10.3389/fphar.2020.01205", "pmid": "33071775", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7533592"}], "notes": [], "created": "2020-11-26T12:24:30.995Z", "modified": "2020-11-26T12:24:31.017Z"}, {"entity": "publication", "iuid": "23b3b226c1804746af8f9473c4c7563f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23b3b226c1804746af8f9473c4c7563f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23b3b226c1804746af8f9473c4c7563f"}}, "title": "Piecewise quadratic growth during the 2019 novel coronavirus epidemic.", "authors": [{"family": "Brandenburg", "given": "Axel", "initials": "A"}], "type": "journal article", "published": "2020-09-11", "journal": {"title": "Infect Dis Model", "issn": "2468-0427", "volume": "5", "issue": null, "pages": "681-690", "issn-l": null}, "abstract": "The temporal growth in the number of deaths in the COVID-19 epidemic is subexponential. Here we show that a piecewise quadratic law provides an excellent fit during the thirty days after the first three fatalities on January 20 and later since the end of March 2020. There is also a brief intermediate period of exponential growth. During the second quadratic growth phase, the characteristic time of the growth is about eight times shorter than in the beginning, which can be understood as the occurrence of separate hotspots. Quadratic behavior can be motivated by peripheral growth when further spreading occurs only on the outskirts of an infected region. We also study numerical solutions of a simple epidemic model, where the spatial extend of the system is taken into account. To model the delayed onset outside China together with the early one in China within a single model with minimal assumptions, we adopt an initial condition of several hotspots, of which one reaches saturation much earlier than the others. At each site, quadratic growth commences when the local number of infections has reached a certain saturation level. The total number of deaths does then indeed follow a piecewise quadratic behavior.", "doi": "10.1016/j.idm.2020.08.014", "pmid": "32954094", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2468-0427(20)30044-0"}, {"db": "pmc", "key": "PMC7485523"}], "notes": [], "created": "2020-12-03T09:33:11.690Z", "modified": "2020-12-03T09:33:11.704Z"}, {"entity": "publication", "iuid": "1ec555708e424f25a0d57786d6bd022e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ec555708e424f25a0d57786d6bd022e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ec555708e424f25a0d57786d6bd022e"}}, "title": "Development, clinical translation, and utility of a COVID-19 antibody test with qualitative and quantitative readouts.", "authors": [{"family": "Bortz", "given": "Robert H", "initials": "RH"}, {"family": "Florez", "given": "Catalina", "initials": "C"}, {"family": "Laudermilch", "given": "Ethan", "initials": "E"}, {"family": "Wirchnianski", "given": "Ariel S", "initials": "AS"}, {"family": "Lasso", "given": "Gorka", "initials": "G"}, {"family": "Malonis", "given": "Ryan J", "initials": "RJ"}, {"family": "Georgiev", "given": "George I", "initials": "GI"}, {"family": "Vergnolle", "given": "Olivia", "initials": "O"}, {"family": "Herrera", "given": "Natalia G", "initials": "NG"}, {"family": "Morano", "given": "Nicholas C", "initials": "NC"}, {"family": "Campbell", "given": "Sean T", "initials": "ST"}, {"family": "Orner", "given": "Erika P", "initials": "EP"}, {"family": "Mengotto", "given": "Amanda", "initials": "A"}, {"family": "Dieterle", "given": "M Eugenia", "initials": "ME"}, {"family": "Fels", "given": "Jens Maximilian", "initials": "JM"}, {"family": "Haslwanter", "given": "Denise", "initials": "D"}, {"family": "Jangra", "given": "Rohit", "initials": "R"}, {"family": "Celikgil", "given": "Alev", "initials": "A"}, {"family": "Kimmel", "given": "Duncan", "initials": "D"}, {"family": "Lee", "given": "James H", "initials": "JH"}, {"family": "Mariano", "given": "Margarette", "initials": "M"}, {"family": "Nakouzi", "given": "Antonio", "initials": "A"}, {"family": "Quiroz", "given": "Jose", "initials": "J"}, {"family": "Rivera", "given": "Johanna", "initials": "J"}, {"family": "Szymczak", "given": "Wendy A", "initials": "WA"}, {"family": "Tong", "given": "Karen", "initials": "K"}, {"family": "Barnhill", "given": "Jason", "initials": "J"}, {"family": "Forsell", "given": "Mattias Ne", "initials": "MN"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Stein", "given": "Daniel T", "initials": "DT"}, {"family": "Pirofski", "given": "Liise-Anne", "initials": "L"}, {"family": "Goldstein", "given": "Doctor Y", "initials": "DY"}, {"family": "Garforth", "given": "Scott J", "initials": "SJ"}, {"family": "Almo", "given": "Steven C", "initials": "SC"}, {"family": "Daily", "given": "Johanna P", "initials": "JP"}, {"family": "Prystowsky", "given": "Michael B", "initials": "MB"}, {"family": "Faix", "given": "James D", "initials": "JD"}, {"family": "Fox", "given": "Amy S", "initials": "AS"}, {"family": "Weiss", "given": "Louis M", "initials": "LM"}, {"family": "Lai", "given": "Jonathan R", "initials": "JR"}, {"family": "Chandran", "given": "Kartik", "initials": "K"}], "type": "preprint", "published": "2020-09-11", "journal": {"title": "mSphere", "issn": "2379-5042", "issn-l": null, "volume": "6", "issue": "2", "pages": null}, "abstract": "The COVID-19 global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to place an immense burden on societies and healthcare systems. A key component of COVID-19 control efforts is serologic testing to determine the community prevalence of SARS-CoV-2 exposure and quantify individual immune responses to prior infection or vaccination. Here, we describe a laboratory-developed antibody test that uses readily available research-grade reagents to detect SARS-CoV-2 exposure in patient blood samples with high sensitivity and specificity. We further show that this test affords the estimation of viral spike-specific IgG titers from a single sample measurement, thereby providing a simple and scalable method to measure the strength of an individual's immune response. The accuracy, adaptability, and cost-effectiveness of this test makes it an excellent option for clinical deployment in the ongoing COVID-19 pandemic.", "doi": "10.1128/mSphere.00224-21", "pmid": null, "labels": {"Category: Biochemistry": null, "Category: Health": null, "Category: Serology": null, "Category: Proteins": null, "Type: Journal article": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-11-04T15:35:31.660Z", "modified": "2021-04-23T04:34:32.198Z"}, {"entity": "publication", "iuid": "44c735f6e3364a05a857311d3471133b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44c735f6e3364a05a857311d3471133b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44c735f6e3364a05a857311d3471133b"}}, "title": "Can intravenous oxytocin infusion counteract hyperinflammation in COVID-19 infected patients?", "authors": [{"family": "Buemann", "given": "Benjamin", "initials": "B"}, {"family": "Marazziti", "given": "Donatella", "initials": "D"}, {"family": "Uvn\u00e4s-Moberg", "given": "Kerstin", "initials": "K"}], "type": "journal article", "published": "2020-09-11", "journal": {"title": "World J Biol Psychiatry", "issn": "1814-1412", "volume": null, "issue": null, "pages": "1-12", "issn-l": null}, "abstract": "Based on its well-documented anti-inflammatory and restorative properties we propose trials with the natural hormone oxytocin for treatment of hospitalised Covid-19 patients.\n\nWe searched for, retrieved, and commented on specific literature regarding multiple functions of oxytocin with a special focus on its modulation of inflammatory, immune, and restorative functions.\n\nAvailable data gathered in animals and humans support the anti-inflammatory properties of oxytocin. The multiple anti-inflammatory effects of oxytocin have been demonstrated in vitro and in vivo in various animal models and also in humans in response to intravenous infusion of oxytocin. Furthermore, oxytocin has been documented to activate several types of protective and restorative mechanisms and to exert positive effects on the immune system.\n\nIn addition, to being anti-inflammatory, it may be hypothesised, that oxytocin may be less suppressive on adaptive immune systems, as compared with glucocorticoids. Finally, by its restorative effects coupled with its anti-stress and healing properties, oxytocin may shorten the recovery period of the Covid-19 patients.", "doi": "10.1080/15622975.2020.1814408", "pmid": "32914674", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-03T15:50:41.427Z", "modified": "2020-12-03T15:50:41.437Z"}, {"entity": "publication", "iuid": "c0dccb4b5d464861a2edc7e0621fa33f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c0dccb4b5d464861a2edc7e0621fa33f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c0dccb4b5d464861a2edc7e0621fa33f"}}, "title": "Covid-19 as cultural trauma.", "authors": [{"family": "Demertzis", "given": "Nicolas", "initials": "N"}, {"family": "Eyerman", "given": "Ron", "initials": "R"}], "type": "journal article", "published": "2020-09-10", "journal": {"title": "Am J Cult Sociol", "issn": "2049-7113", "volume": null, "issue": null, "pages": "1-23", "issn-l": null}, "abstract": "This paper has two aims. The first is to introduce the concept of compressed cultural trauma, and the second is to apply the theory of cultural trauma in two case studies of the current covid-19 pandemic, Greece and Sweden. Our central question is whether the pandemic will evolve into a cultural trauma in these two countries. We believe the pandemic presents a challenge to cultural trauma theory, which the idea of compressed trauma is meant to address. We conclude that, while the ongoing covid-19 pandemic has had traumatic consequences in Sweden and Greece, it has not evolved into cultural trauma in either country.", "doi": "10.1057/s41290-020-00112-z", "pmid": "32929388", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "112"}, {"db": "pmc", "key": "PMC7481543"}], "notes": [], "created": "2020-12-03T15:35:12.134Z", "modified": "2020-12-03T15:35:12.159Z"}, {"entity": "publication", "iuid": "2edf22a701b24f3a9e15b94b30781900", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2edf22a701b24f3a9e15b94b30781900.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2edf22a701b24f3a9e15b94b30781900"}}, "title": "COVID-19 Pandemic Control: Lessons Learned From Hai Phong City, Vietnam.", "authors": [{"family": "Tran", "given": "Thanh Chi", "initials": "TC"}, {"family": "Ngo", "given": "The Anh", "initials": "TA"}, {"family": "Nguyen", "given": "Thanh Duc", "initials": "TD"}, {"family": "Olson", "given": "Linus", "initials": "L"}, {"family": "Larsson", "given": "Mattias", "initials": "M"}], "type": "journal article", "published": "2020-09-10", "journal": {"title": "Asia Pac J Public Health", "issn": "1941-2479", "volume": null, "issue": null, "pages": "1010539520956424", "issn-l": null}, "abstract": "The COVID-19 (coronavirus disease-2019) pandemic has affected almost all countries in the world. When the first cases were reported from Hubei, China, in late December 2019, the Vietnamese authorities acknowledged the potential risk of an epidemic having had the experience of severe acute respiratory syndrome (SARS) and the Avian flu. When it was clear that there was human-to-human transmission in the epidemic in Wuhan that started in January 2020, the Vietnamese government, health care system, and civil society were rapidly mobilized. How has a country with a population of about 100 million and a long porous border to China managed to prevent a larger outbreak? This case history is about how Hai Phong city implemented the initial COVID-19 response. Hai Phong reacted quickly after the COVID-19 outbreak in China by, quarantining people coming from pandemic areas, and carrying out contact tracing and extensive testing, closing schools and universities and implementing two weeks of social distancing measures. There are no detected positive cases until May 18, 2020 in Hai Phong.", "doi": "10.1177/1010539520956424", "pmid": "32909472", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-03T15:51:38.418Z", "modified": "2020-12-03T15:51:38.442Z"}, {"entity": "publication", "iuid": "56b0b53e67ce45b68fad60337e0aa7a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56b0b53e67ce45b68fad60337e0aa7a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56b0b53e67ce45b68fad60337e0aa7a6"}}, "title": "Is COVID-19 spreading and curing silently: an observation of three family clusters in Bangladesh.", "authors": [{"family": "Hoq", "given": "Mohammad Injamul", "initials": "MI"}, {"family": "Hossain", "given": "Md Mohotasin", "initials": "MM"}, {"family": "Roshni", "given": "Umme Sayma", "initials": "US"}, {"family": "Sayeed", "given": "Mohammed Aktar", "initials": "MA"}, {"family": "Tohura", "given": "Saraban", "initials": "S"}, {"family": "Jakaria", "given": "Md", "initials": "M"}], "type": "case reports", "published": "2020-09-09", "journal": {"title": "J Basic Clin Physiol Pharmacol", "issn": "2191-0286", "issn-l": null, "volume": "31", "issue": "6", "pages": null}, "abstract": "Objectives The number of coronavirus disease (COVID-19) cases is increasing in Bangladesh. Many people have suffered from symptoms like COVID-19 during this pandemic, and some people have cured without taking any treatment or taking minor pharmacological and non-pharmacological treatments. However, they might be spreading their infections among their family members and perhaps in the community. It is unsure that individuals with COVID-19-like symptoms are positive with COVID-19, but our concern is, during this pandemic, any types of symptoms such as flu-like symptoms should have been taken seriously. This study was observed in the cases from three families with COVID-19 like symptoms. Case presentation This observational study was done between May 20 and Jun 2, 2020, in Bangladesh. The members of the inspected families shared COVID-19 like symptoms that were lasted for 3-10 days. Conclusions COVID-19 might be spread and cured silently in Bangladesh, which recommends that awareness is needed throughout the country to prevent the spreading of the disease.", "doi": "10.1515/jbcpp-2020-0224", "pmid": "32903208", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "/j/jbcpp.ahead-of-print/jbcpp-2020-0224/jbcpp-2020-0224.xml"}], "notes": [], "created": "2020-12-03T16:16:25.822Z", "modified": "2022-11-10T06:39:33.321Z"}, {"entity": "publication", "iuid": "eb78f8ab3f6c40afbc9c4dbb77e7d827", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb78f8ab3f6c40afbc9c4dbb77e7d827.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb78f8ab3f6c40afbc9c4dbb77e7d827"}}, "title": "What do people hospitalised with covid-19 think about the care they received?", "authors": [{"family": "Wu", "given": "Meng-San", "initials": "MS"}, {"family": "Hayat", "given": "Fatima", "initials": "F"}, {"family": "Ratcliffe", "given": "Libuse", "initials": "L"}, {"family": "Beadsworth", "given": "Mike B J", "initials": "MBJ"}, {"family": "Defres", "given": "Sylviane", "initials": "S"}, {"family": "Wingfield", "given": "Tom", "initials": "T"}], "type": "letter", "published": "2020-09-08", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "370", "issue": null, "pages": "m3496", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m3496", "pmid": "32900791", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-06T07:15:59.881Z", "modified": "2020-12-06T07:16:27.079Z"}, {"entity": "publication", "iuid": "6f64f5b4044d4dad891fbcc8cae95651", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f64f5b4044d4dad891fbcc8cae95651.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f64f5b4044d4dad891fbcc8cae95651"}}, "title": "The influence of sex and gender domains on COVID-19 cases and mortality.", "authors": [{"family": "Tadiri", "given": "Christina P", "initials": "CP"}, {"family": "Gisinger", "given": "Teresa", "initials": "T"}, {"family": "Kautzy-Willer", "given": "Alexandra", "initials": "A"}, {"family": "Kublickiene", "given": "Karolina", "initials": "K"}, {"family": "Herrero", "given": "Maria Trinidad", "initials": "MT"}, {"family": "Raparelli", "given": "Valeria", "initials": "V"}, {"family": "Pilote", "given": "Louise", "initials": "L"}, {"family": "Norris", "given": "Colleen M", "initials": "CM"}, {"family": "GOING-FWD Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2020-09-08", "journal": {"title": "CMAJ", "issn": "1488-2329", "volume": "192", "issue": "36", "pages": "E1041-E1045", "issn-l": null}, "abstract": null, "doi": "10.1503/cmaj.200971", "pmid": "32900766", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "192/36/E1041"}, {"db": "pmc", "key": "PMC7504881"}], "notes": [], "created": "2020-12-06T07:20:20.362Z", "modified": "2020-12-06T07:20:20.386Z"}, {"entity": "publication", "iuid": "3a3b8e0c4e7c43e9aac18620677bfd64", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a3b8e0c4e7c43e9aac18620677bfd64.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a3b8e0c4e7c43e9aac18620677bfd64"}}, "title": "Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates.", "authors": [{"family": "Damas", "given": "Joana", "initials": "J", "orcid": "0000-0003-4857-2510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d86c6ce3efc8438cb022b0a6116ec808.json"}}, {"family": "Hughes", "given": "Graham M", "initials": "GM", "orcid": "0000-0003-3088-345X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7cca5ad139542a09d41aacc87cef194.json"}}, {"family": "Keough", "given": "Kathleen C", "initials": "KC", "orcid": "0000-0002-7481-0511", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31418e90941f44ed9f7baac2fc2b0ca5.json"}}, {"family": "Painter", "given": "Corrie A", "initials": "CA", "orcid": "0000-0001-6174-1548", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b93e610d9a7448d2b1b04013fee689e3.json"}}, {"family": "Persky", "given": "Nicole S", "initials": "NS", "orcid": "0000-0002-9948-2761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b64350d9c0a406396b36eabd6c372c4.json"}}, {"family": "Corbo", "given": "Marco", "initials": "M", "orcid": "0000-0002-4566-2724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67850769221d40e3bc798c393b4f559f.json"}}, {"family": "Hiller", "given": "Michael", "initials": "M", "orcid": "0000-0003-3024-1449", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74b8c53343314dde971b5f1d9ba7adc4.json"}}, {"family": "Koepfli", "given": "Klaus-Peter", "initials": "KP", "orcid": "0000-0001-7281-0676", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb8ddd52615d4685adb7985d9a79f361.json"}}, {"family": "Pfenning", "given": "Andreas R", "initials": "AR", "orcid": "0000-0002-3447-9801", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35a8a125b8ba47378aa05db0f82c774b.json"}}, {"family": "Zhao", "given": "Huabin", "initials": "H", "orcid": "0000-0002-7848-6392", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ff10d2b3b3c4465ae9edf8d8e270fd9.json"}}, {"family": "Genereux", "given": "Diane P", "initials": "DP", "orcid": "0000-0001-5770-0989", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59c3f0cfa3bf46f58e5ee2d98a935a2c.json"}}, {"family": "Swofford", "given": "Ross", "initials": "R", "orcid": "0000-0003-3676-8479", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e4973c0096a496fb46269c0d1e1e8d1.json"}}, {"family": "Pollard", "given": "Katherine S", "initials": "KS", "orcid": "0000-0002-9870-6196", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5281b158f9334e39a18cfb618cd1f6fc.json"}}, {"family": "Ryder", "given": "Oliver A", "initials": "OA", "orcid": "0000-0003-2427-763X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e2fd53a69c14ea0a555a974df5186f1.json"}}, {"family": "Nweeia", "given": "Martin T", "initials": "MT", "orcid": "0000-0001-7079-4123", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12f0f63b2b3545f8a6f76bdf9c9c10b3.json"}}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K", "orcid": "0000-0001-8338-0253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/159b64d0fe104764b779588736155088.json"}}, {"family": "Teeling", "given": "Emma C", "initials": "EC", "orcid": "0000-0002-3309-1346", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a9c530af6e24c07931ae16eed8fd5ed.json"}}, {"family": "Karlsson", "given": "Elinor K", "initials": "EK", "orcid": "0000-0002-4343-3776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff1d0b875064bc9b8c54d5af01ec13c.json"}}, {"family": "Lewin", "given": "Harris A", "initials": "HA", "orcid": "0000-0002-1043-7287", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8feb3ed5d3a14dea95ed77742bd1e569.json"}}], "type": "comparative study", "published": "2020-09-08", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "117", "issue": "36", "pages": "22311-22322", "issn-l": "0027-8424"}, "abstract": "The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19. The main receptor of SARS-CoV-2, angiotensin I converting enzyme 2 (ACE2), is now undergoing extensive scrutiny to understand the routes of transmission and sensitivity in different species. Here, we utilized a unique dataset of ACE2 sequences from 410 vertebrate species, including 252 mammals, to study the conservation of ACE2 and its potential to be used as a receptor by SARS-CoV-2. We designed a five-category binding score based on the conservation properties of 25 amino acids important for the binding between ACE2 and the SARS-CoV-2 spike protein. Only mammals fell into the medium to very high categories and only catarrhine primates into the very high category, suggesting that they are at high risk for SARS-CoV-2 infection. We employed a protein structural analysis to qualitatively assess whether amino acid changes at variable residues would be likely to disrupt ACE2/SARS-CoV-2 spike protein binding and found the number of predicted unfavorable changes significantly correlated with the binding score. Extending this analysis to human population data, we found only rare (frequency <0.001) variants in 10/25 binding sites. In addition, we found significant signals of selection and accelerated evolution in the ACE2 coding sequence across all mammals, and specific to the bat lineage. Our results, if confirmed by additional experimental data, may lead to the identification of intermediate host species for SARS-CoV-2, guide the selection of animal models of COVID-19, and assist the conservation of animals both in native habitats and in human care.", "doi": "10.1073/pnas.2010146117", "pmid": "32826334", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7486773"}, {"db": "pii", "key": "2010146117"}], "notes": [], "created": "2020-12-07T11:52:39.925Z", "modified": "2023-06-19T14:38:30.044Z"}, {"entity": "publication", "iuid": "3e9b231b9d9a4b1d837d4b4ebf1662db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3e9b231b9d9a4b1d837d4b4ebf1662db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3e9b231b9d9a4b1d837d4b4ebf1662db"}}, "title": "Acute necrotizing encephalopathy with SARS-CoV-2 RNA confirmed in cerebrospinal fluid", "authors": [{"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "F\u00e4llmar", "given": "David", "initials": "D"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Jackmann", "given": "Sven", "initials": "S"}, {"family": "Sk\u00f6ld", "given": "Mattias K", "initials": "MK"}, {"family": "Kadir", "given": "Mohamed", "initials": "M"}, {"family": "Frick", "given": "Jens", "initials": "J"}, {"family": "Lindeberg", "given": "Jonas", "initials": "J"}, {"family": "Olivero-Reinius", "given": "Henrik", "initials": "H"}, {"family": "Ryttlefors", "given": "Mats", "initials": "M"}, {"family": "Cunningham", "given": "Janet L", "initials": "JL"}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Grabowska", "given": "Anna", "initials": "A"}, {"family": "Bondeson", "given": "K\u00e5re", "initials": "K"}, {"family": "Bergquist", "given": "Jonas", "initials": "J"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Rostami", "given": "Elham", "initials": "E"}], "type": "journal-article", "published": "2020-09-08", "journal": {"title": "Neurology", "issn": "1526-632X", "volume": "95", "issue": "10", "pages": "445-449", "issn-l": "0028-3878"}, "abstract": "Here, we report a case of COVID-19\u2013related acute necrotizing encephalopathy where SARS-CoV-2 RNA was found in CSF 19 days after symptom onset after testing negative twice. Although monocytes and protein levels in CSF were only marginally increased, and our patient never experienced a hyperinflammatory state, her neurologic function deteriorated into coma. MRI of the brain showed pathologic signal symmetrically in central thalami, subinsular regions, medial temporal lobes, and brain stem. Extremely high concentrations of the neuronal injury markers neurofilament light and tau, as well as an astrocytic activation marker, glial fibrillary acidic protein, were measured in CSF. Neuronal rescue proteins and other pathways were elevated in the in-depth proteomics analysis. The patient received IV immunoglobulins and plasma exchange. Her neurologic status improved, and she was extubated 4 weeks after symptom onset. This case report highlights the neurotropism of SARS-CoV-2 in selected patients and emphasizes the importance of repeated lumbar punctures and CSF analyses in patients with suspected COVID-19 and neurologic symptoms.", "doi": "10.1212/wnl.0000000000010250", "pmid": "32586897", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.5061/dryad.xwdbrv1bb", "description": "Proteomic data"}], "notes": [], "created": "2020-11-04T07:45:09.549Z", "modified": "2021-02-26T08:45:48.083Z"}, {"entity": "publication", "iuid": "ac5dc94540534786a6d4b0d8241c1d1c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac5dc94540534786a6d4b0d8241c1d1c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac5dc94540534786a6d4b0d8241c1d1c"}}, "title": "Use of biologicals in allergic and type-2 inflammatory diseases during the current COVID-19 pandemic: Position paper of \u00c4rzteverband Deutscher Allergologen (AeDA) A, Deutsche Gesellschaft f\u00fcr Allergologie und Klinische Immunologie (DGAKI)B, Gesellschaft f\u00fcr P\u00e4diatrische Allergologie und Umweltmedizin (GPA)C, \u00d6sterreichische Gesellschaft f\u00fcr Allergologie und Immunologie (\u00d6GAI)D, Luxemburgische Gesellschaft f\u00fcr Allergologie und Immunologie (LGAI)E, \u00d6sterreichische Gesellschaft f\u00fcr Pneumologie (\u00d6GP)F in co-operation with the German, Austrian, and Swiss ARIA groupsG, and the European Academy of Allergy and Clinical Immunology (EAACI)H.", "authors": [{"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Worm", "given": "Margitta", "initials": "M"}, {"family": "Eiwegger", "given": "Thomas", "initials": "T"}, {"family": "Hagemann", "given": "Jan", "initials": "J"}, {"family": "Ollert", "given": "Markus", "initials": "M"}, {"family": "Untersmayr", "given": "Eva", "initials": "E"}, {"family": "Hoffmann-Sommergruber", "given": "Karin", "initials": "K"}, {"family": "Vultaggio", "given": "Alessandra", "initials": "A"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Bavbek", "given": "Sevim", "initials": "S"}, {"family": "Bossios", "given": "Apostolos", "initials": "A"}, {"family": "Casper", "given": "Ingrid", "initials": "I"}, {"family": "Chan", "given": "Susan", "initials": "S"}, {"family": "Chatzipetrou", "given": "Alexia", "initials": "A"}, {"family": "Vogelberg", "given": "Christian", "initials": "C"}, {"family": "Firinu", "given": "Davide", "initials": "D"}, {"family": "Kauppi", "given": "Paula", "initials": "P"}, {"family": "Kolios", "given": "Antonios", "initials": "A"}, {"family": "Kothari", "given": "Akash", "initials": "A"}, {"family": "Matucci", "given": "Andrea", "initials": "A"}, {"family": "Palomares", "given": "Oscar", "initials": "O"}, {"family": "Sz\u00e9pfalusi", "given": "Zsolt", "initials": "Z"}, {"family": "Pohl", "given": "Wolfgang", "initials": "W"}, {"family": "H\u00f6tzenecker", "given": "Wolfram", "initials": "W"}, {"family": "Rosenkranz", "given": "Alexander R", "initials": "AR"}, {"family": "Bergmann", "given": "Karl-Christian", "initials": "KC"}, {"family": "Bieber", "given": "Thomas", "initials": "T"}, {"family": "Buhl", "given": "Roland", "initials": "R"}, {"family": "Buters", "given": "Jeroen", "initials": "J"}, {"family": "Darsow", "given": "Ulf", "initials": "U"}, {"family": "Keil", "given": "Thomas", "initials": "T"}, {"family": "Kleine-Tebbe", "given": "J\u00f6rg", "initials": "J"}, {"family": "Lau", "given": "Susanne", "initials": "S"}, {"family": "Maurer", "given": "Marcus", "initials": "M"}, {"family": "Merk", "given": "Hans", "initials": "H"}, {"family": "M\u00f6sges", "given": "Ralph", "initials": "R"}, {"family": "Saloga", "given": "Joachim", "initials": "J"}, {"family": "Staubach", "given": "Petra", "initials": "P"}, {"family": "Jappe", "given": "Uta", "initials": "U"}, {"family": "Rabe", "given": "Klaus F", "initials": "KF"}, {"family": "Rabe", "given": "Uta", "initials": "U"}, {"family": "Vogelmeier", "given": "Claus", "initials": "C"}, {"family": "Biedermann", "given": "Tilo", "initials": "T"}, {"family": "Jung", "given": "Kirsten", "initials": "K"}, {"family": "Schlenter", "given": "Wolfgang", "initials": "W"}, {"family": "Ring", "given": "Johannes", "initials": "J"}, {"family": "Chaker", "given": "Adam", "initials": "A"}, {"family": "Wehrmann", "given": "Wolfgang", "initials": "W"}, {"family": "Becker", "given": "Sven", "initials": "S"}, {"family": "Freudelsperger", "given": "Laura", "initials": "L"}, {"family": "M\u00fclleneisen", "given": "Norbert", "initials": "N"}, {"family": "Nemat", "given": "Katja", "initials": "K"}, {"family": "Czech", "given": "Wolfgang", "initials": "W"}, {"family": "Wrede", "given": "Holger", "initials": "H"}, {"family": "Brehler", "given": "Randolf", "initials": "R"}, {"family": "Fuchs", "given": "Thomas", "initials": "T"}, {"family": "Tomazic", "given": "Peter-Valentin", "initials": "PV"}, {"family": "Aberer", "given": "Werner", "initials": "W"}, {"family": "Fink-Wagner", "given": "Antje-Henriette", "initials": "AH"}, {"family": "Horak", "given": "Fritz", "initials": "F"}, {"family": "W\u00f6hrl", "given": "Stefan", "initials": "S"}, {"family": "Niederberger-Leppin", "given": "Verena", "initials": "V"}, {"family": "Pali-Sch\u00f6ll", "given": "Isabella", "initials": "I"}, {"family": "Roller-Wirnsberger", "given": "Regina", "initials": "R"}, {"family": "Spranger", "given": "Otto", "initials": "O"}, {"family": "Valenta", "given": "Rudolf", "initials": "R"}, {"family": "Akdis", "given": "M\u00fcbecell", "initials": "M"}, {"family": "Matricardi", "given": "Paolo M", "initials": "PM"}, {"family": "Spertini", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Khaltaev", "given": "Nicolai", "initials": "N"}, {"family": "Michel", "given": "Jean-Pierre", "initials": "JP"}, {"family": "Nicod", "given": "Larent", "initials": "L"}, {"family": "Schmid-Grendelmeier", "given": "Peter", "initials": "P"}, {"family": "Idzko", "given": "Marco", "initials": "M"}, {"family": "Hamelmann", "given": "Eckard", "initials": "E"}, {"family": "Jakob", "given": "Thilo", "initials": "T"}, {"family": "Werfel", "given": "Thomas", "initials": "T"}, {"family": "Wagenmann", "given": "Martin", "initials": "M"}, {"family": "Taube", "given": "Christian", "initials": "C"}, {"family": "Jensen-Jarolim", "given": "Erika", "initials": "E"}, {"family": "Korn", "given": "Stephanie", "initials": "S"}, {"family": "Hentges", "given": "Francois", "initials": "F"}, {"family": "Schwarze", "given": "J\u00fcrgen", "initials": "J"}, {"family": "O Mahony", "given": "Liam", "initials": "L"}, {"family": "Knol", "given": "Edward F", "initials": "EF"}, {"family": "Del Giacco", "given": "Stefano", "initials": "S"}, {"family": "Chivato P\u00e9rez", "given": "Tom\u00e1s", "initials": "T"}, {"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Bedbrook", "given": "Anna", "initials": "A"}, {"family": "Zuberbier", "given": "Torsten", "initials": "T"}, {"family": "Akdis", "given": "Cezmi", "initials": "C"}, {"family": "Jutel", "given": "Marek", "initials": "M"}], "type": "journal article", "published": "2020-09-07", "journal": {"title": "Allergol Select", "issn": "2512-8957", "volume": "4", "issue": null, "pages": "53-68", "issn-l": null}, "abstract": "Since the beginning of the COVID-19 pandemic, the treatment of patients with allergic and atopy-associated diseases has faced major challenges. Recommendations for \"social distancing\" and the fear of patients becoming infected during a visit to a medical facility have led to a drastic decrease in personal doctor-patient contacts. This affects both acute care and treatment of the chronically ill. The immune response after SARS-CoV-2 infection is so far only insufficiently understood and could be altered in a favorable or unfavorable way by therapy with monoclonal antibodies. There is currently no evidence for an increased risk of a severe COVID-19 course in allergic patients. Many patients are under ongoing therapy with biologicals that inhibit type 2 immune responses via various mechanisms. There is uncertainty about possible immunological interactions and potential risks of these biologicals in the case of an infection with SARS-CoV-2.\n\nA selective literature search was carried out in PubMed, Livivo, and the internet to cover the past 10 years (May 2010 - April 2020). Additionally, the current German-language publications were analyzed. Based on these data, the present position paper provides recommendations for the biological treatment of patients with allergic and atopy-associated diseases during the COVID-19 pandemic.\n\nIn order to maintain in-office consultation services, a safe treatment environment must be created that is adapted to the pandemic situation. To date, there is a lack of reliable study data on the care for patients with complex respiratory, atopic, and allergic diseases in times of an imminent infection risk from SARS-CoV-2. Type-2-dominant immune reactions, as they are frequently seen in allergic patients, could influence various phases of COVID-19, e.g., by slowing down the immune reactions. Theoretically, this could have an unfavorable effect in the early phase of a SARS-Cov-2 infection, but also a positive effect during a cytokine storm in the later phase of severe courses. However, since there is currently no evidence for this, all data from patients treated with a biological directed against type 2 immune reactions who develop COVID-19 should be collected in registries, and their disease courses documented in order to be able to provide experience-based instructions in the future.\n\nThe use of biologicals for the treatment of bronchial asthma, atopic dermatitis, chronic rhinosinusitis with nasal polyps, and spontaneous urticaria should be continued as usual in patients without suspected infection or proven SARS-CoV-2 infection. If available, it is recommended to prefer a formulation for self-application and to offer telemedical monitoring. Treatment should aim at the best possible control of difficult-to-control allergic and atopic diseases using adequate rescue and add-on therapy and should avoid the need for systemic glucocorticosteroids. If SARS-CoV-2 infection is proven or reasonably suspected, the therapy should be determined by weighing the benefits and risks individually for the patient in question, and the patient should be involved in the decision-making. It should be kept in mind that the potential effects of biologicals on the immune response in COVID-19 are currently not known. Telemedical offers are particularly desirable for the acute consultation needs of suitable patients.", "doi": "10.5414/ALX02166E", "pmid": "32915172", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7480069"}], "notes": [], "created": "2020-12-03T15:49:30.607Z", "modified": "2020-12-03T15:49:30.629Z"}, {"entity": "publication", "iuid": "38380a4ee3434dedb9da6814ea406069", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38380a4ee3434dedb9da6814ea406069.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38380a4ee3434dedb9da6814ea406069"}}, "title": "Characteristics and outcomes of patients with COVID-19 admitted to ICU in a tertiary hospital in Stockholm, Sweden.", "authors": [{"family": "Larsson", "given": "Emma", "initials": "E"}, {"family": "Brattstr\u00f6m", "given": "Olof", "initials": "O"}, {"family": "Agvald-\u00d6hman", "given": "Christina", "initials": "C"}, {"family": "Grip", "given": "Jonathan", "initials": "J"}, {"family": "Campoccia Jalde", "given": "Francesca", "initials": "F"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}, {"family": "Oldner", "given": "Anders", "initials": "A"}, {"family": "Konrad", "given": "David", "initials": "D"}, {"family": "Persson", "given": "Bj\u00f6rn P", "initials": "BP"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}, {"family": "Karolinska Intensive Care COVID-19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-09-06", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": "65", "issue": "1", "pages": "76-81"}, "abstract": "Information on characteristics and outcomes of intensive care unit (ICU) patients with COVID-19 remains limited. We examined characteristics, clinical course and early outcomes of patients with COVID-19 admitted to ICU.\r\n\r\nWe included all 260 patients with COVID-19 admitted to nine ICUs at the Karolinska University Hospital (Stockholm, Sweden) between 9 March and 20 April 2020. Primary outcome was in-hospital mortality among patients with definite outcomes (discharged from ICU or death), as of 30 April 2020 (study end point). Secondary outcomes included ICU length of stay, the proportion of patients receiving mechanical ventilation and renal replacement therapy, and hospital discharge destination.\r\n\r\nOf 260 ICU patients with COVID-19, 208 (80.0%) were men, the median age was 59 (IQR 51-65) years, 154 (59.2%) had at least one comorbidity, and the median duration of symptoms preceding ICU admission was 11 (IQR 8-14) days. Sixty-two (23.8%) patients remained in ICU at study end point. Among the 198 patients with definite outcomes, ICU length of stay was 12 (IQR, 6-18) days, 163 (82.3%) received mechanical ventilation, 28 (14.1%) received renal replacement therapy, 60 (30.3%) died, 62 (31.3%) were discharged home, 47 (23.7%) were discharged to ward, and 29 (14.6%) were discharged to another health care facility. On multivariable logistic regression analysis, older age and admission from the emergency department was associated with higher mortality.\r\n\r\nThis study presents detailed data on clinical characteristics and early outcomes of consecutive patients with COVID-19 admitted to ICU in a large tertiary hospital in Sweden.", "doi": "10.1111/aas.13694", "pmid": "32892337", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-10-30T11:51:51.497Z", "modified": "2021-02-26T08:45:48.054Z"}, {"entity": "publication", "iuid": "0844d9bb4cf3455ca7975029df6d3bc0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0844d9bb4cf3455ca7975029df6d3bc0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0844d9bb4cf3455ca7975029df6d3bc0"}}, "title": "A Parsimonious Description and Cross-Country Analysis of COVID-19 Epidemic Curves.", "authors": [{"family": "Rypdal", "given": "Kristoffer", "initials": "K"}, {"family": "Rypdal", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2020-09-06", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "18", "pages": null}, "abstract": "In a given country, the cumulative death toll of the first wave of the COVID-19 epidemic follows a sigmoid curve as a function of time. In most cases, the curve is well described by the Gompertz function, which is characterized by two essential parameters, the initial growth rate and the decay rate as the first epidemic wave subsides. These parameters are determined by socioeconomic factors and the countermeasures to halt the epidemic. The Gompertz model implies that the total death toll depends exponentially, and hence very sensitively, on the ratio between these rates. The remarkably different epidemic curves for the first epidemic wave in Sweden and Norway and many other countries are classified and discussed in this framework, and their usefulness for the planning of mitigation strategies is discussed.", "doi": "10.3390/ijerph17186487", "pmid": "32899971", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "ijerph17186487"}, {"db": "pmc", "key": "PMC7559235"}], "notes": [], "created": "2020-12-06T07:16:46.279Z", "modified": "2022-11-10T06:40:21.982Z"}, {"entity": "publication", "iuid": "ed49959fb39d452fadbb4ffa061eb01e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed49959fb39d452fadbb4ffa061eb01e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed49959fb39d452fadbb4ffa061eb01e"}}, "title": "Virions and respiratory droplets in air: Diffusion, drift, and contact with the epithelium.", "authors": [{"family": "Zhdanov", "given": "Vladimir P", "initials": "VP"}, {"family": "Kasemo", "given": "Bengt", "initials": "B"}], "type": "journal article", "published": "2020-09-05", "journal": {"title": "Biosystems", "issn": "1872-8324", "volume": "198", "issue": null, "pages": "104241", "issn-l": null}, "abstract": "Some infections, including e.g. influenza and currently active COVID 19, may be transmitted via air during sneezing, coughing, and talking. This pathway occurs via diffusion and gravity-induced drift of single virions and respiratory droplets consisting primarily of water, including small fraction of nonvolatile matter, and containing virions. These processes are accompanied by water evaporation resulting in reduction of the droplet size. The manifold of information concerning these steps is presented in textbooks and articles not related to virology and the focus is there frequently on biologically irrelevant conditions and/or droplet sizes. In this brief review, we systematically describe the behavior of virions and virion-carrying droplets in air with emphasis on various regimes of diffusion, drift, and evaporation, and estimate the rates of all these steps under virologically relevant conditions. In addition, we discuss the kinetic aspects of the first steps of infection after attachment of virions or virion-carrying droplets to the epithelium, i.e., virion diffusion in the mucus and periciliary layers, penetration into the cells, and the early stage of replication. The presentation is oriented to virologists who are interested in the corresponding physics and to physicists who are interested in application of the physics to virology.", "doi": "10.1016/j.biosystems.2020.104241", "pmid": "32896576", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0303-2647(20)30129-5"}], "notes": [], "created": "2020-11-30T08:36:32.889Z", "modified": "2020-11-30T08:36:32.913Z"}, {"entity": "publication", "iuid": "4955f61547fa4675b79c608a93485b66", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4955f61547fa4675b79c608a93485b66.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4955f61547fa4675b79c608a93485b66"}}, "title": "Sarcoma European and Latin American Network (SELNET) Recommendations on Prioritization in Sarcoma Care During the COVID-19 Pandemic.", "authors": [{"family": "Martin-Broto", "given": "Javier", "initials": "J"}, {"family": "Hindi", "given": "Nadia", "initials": "N"}, {"family": "Aguiar", "given": "Samuel", "initials": "S"}, {"family": "Badilla-Gonz\u00e1lez", "given": "Ronald", "initials": "R"}, {"family": "Castro-Oliden", "given": "Victor", "initials": "V"}, {"family": "Chac\u00f3n", "given": "Matias", "initials": "M"}, {"family": "Correa-Generoso", "given": "Raquel", "initials": "R"}, {"family": "de \u00c1lava", "given": "Enrique", "initials": "E"}, {"family": "Donati", "given": "Davide Mar\u00eda", "initials": "DM"}, {"family": "Eriksson", "given": "Mikael", "initials": "M"}, {"family": "Falla-Jimenez", "given": "Martin", "initials": "M"}, {"family": "German", "given": "Gisela", "initials": "G"}, {"family": "Gobo Silva", "given": "Maria Leticia", "initials": "ML"}, {"family": "Gouin", "given": "Francois", "initials": "F"}, {"family": "Gronchi", "given": "Alessandro", "initials": "A"}, {"family": "Haro-Varas", "given": "Juan Carlos", "initials": "JC"}, {"family": "Jim\u00e9nez-Brenes", "given": "Natalia", "initials": "N"}, {"family": "Kasper", "given": "Bernd", "initials": "B"}, {"family": "Lopes de Mello", "given": "Celso Abdon", "initials": "CA"}, {"family": "Maki", "given": "Robert", "initials": "R"}, {"family": "Mart\u00ednez-Delgado", "given": "Paula", "initials": "P"}, {"family": "Mart\u00ednez-Said", "given": "Hector", "initials": "H"}, {"family": "Martinez-Tlahuel", "given": "Jorge Luis", "initials": "JL"}, {"family": "Morales-P\u00e9rez", "given": "Jose Manuel", "initials": "JM"}, {"family": "Mu\u00f1oz-Casares", "given": "Francisco Cristobal", "initials": "FC"}, {"family": "Nakagawa", "given": "Suely A", "initials": "SA"}, {"family": "Ortiz-Cruz", "given": "Eduardo Jose", "initials": "EJ"}, {"family": "Palmerini", "given": "Emanuela", "initials": "E"}, {"family": "Patel", "given": "Shreyaskumar", "initials": "S"}, {"family": "Moura", "given": "David S", "initials": "DS"}, {"family": "Stacchiotti", "given": "Silvia", "initials": "S"}, {"family": "Sunyach", "given": "Marie Pierre", "initials": "MP"}, {"family": "Valverde", "given": "Claudia M", "initials": "CM"}, {"family": "Waisberg", "given": "Federico", "initials": "F"}, {"family": "Blay", "given": "Jean-Yves", "initials": "JY"}], "type": "journal article", "published": "2020-09-05", "journal": {"title": "Oncologist", "issn": "1549-490X", "volume": null, "issue": null, "issn-l": null}, "abstract": "The COVID-19 outbreak has resulted in collision between patients infected with SARS-CoV-2 and those with cancer on different fronts. Patients with cancer have been impacted by deferral, modification, and even cessation of therapy. Adaptive measures to minimize hospital exposure, following the precautionary principle, have been proposed for cancer care during COVID-19 era. We present here a consensus on prioritizing recommendations across the continuum of sarcoma patient care.\n\nA total of 125 recommendations were proposed in soft-tissue, bone, and visceral sarcoma care. Recommendations were assigned as higher or lower priority if they cannot or can be postponed at least 2-3 months, respectively. The consensus level for each recommendation was classified as \"strongly recommended\" (SR) if more than 90% of experts agreed, \"recommended\" (R) if 75%-90% of experts agreed and \"no consensus\" (NC) if fewer than 75% agreed. Sarcoma experts from 11 countries within the Sarcoma European-Latin American Network (SELNET) consortium participated, including countries in the Americas and Europe. The European Society for Medical Oncology-Magnitude of clinical benefit scale was applied to systemic-treatment recommendations to support prioritization.\n\nThere were 80 SRs, 35 Rs, and 10 NCs among the 125 recommendations issued and completed by 31 multidisciplinary sarcoma experts. The consensus was higher among the 75 higher-priority recommendations (85%, 12%, and 3% for SR, R, and NC, respectively) than in the 50 lower-priority recommendations (32%, 52%, and 16% for SR, R, and NC, respectively).\n\nThe consensus on 115 of 125 recommendations indicates a high-level of convergence among experts. The SELNET consensus provides a tool for sarcoma multidisciplinary treatment committees during the COVID-19 outbreak.\n\nThe Sarcoma European-Latin American Network (SELNET) consensus on sarcoma prioritization care during the COVID-19 era issued 125 pragmatical recommendations distributed as higher or lower priority to protect critical decisions on sarcoma care during the COVID-19 pandemic. A multidisciplinary team from 11 countries reached consensus on 115 recommendations. The consensus was lower among lower-priority recommendations, which shows reticence to postpone actions even in indolent tumors. The European Society for Medical Oncology-Magnitude of Clinical Benefit scale was applied as support for prioritizing systemic treatment. Consensus on 115 of 125 recommendations indicates a high level of convergence among experts. The SELNET consensus provides a practice tool for guidance in the decisions of sarcoma multidisciplinary treatment committees during the COVID-19 outbreak.", "doi": "10.1634/theoncologist.2020-0516", "pmid": "32888360", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7543334"}], "notes": [], "created": "2020-12-06T07:27:04.756Z", "modified": "2020-12-06T07:27:04.766Z"}, {"entity": "publication", "iuid": "f35daacf9246431abd1b5eac85d3010c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f35daacf9246431abd1b5eac85d3010c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f35daacf9246431abd1b5eac85d3010c"}}, "title": "Treatment with angiotensin II in COVID-19 patients may not be beneficial.", "authors": [{"family": "Rysz", "given": "Susanne", "initials": "S"}, {"family": "Jalde", "given": "Francesca Campoccia", "initials": "FC"}, {"family": "Oldner", "given": "Anders", "initials": "A"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Lundberg", "given": "Johan", "initials": "J"}, {"family": "Fagerlund", "given": "Malin Jonsson", "initials": "MJ"}], "type": "letter", "published": "2020-09-04", "journal": {"title": "Crit Care", "issn": "1466-609X", "volume": "24", "issue": "1", "pages": "546", "issn-l": "1364-8535"}, "abstract": null, "doi": "10.1186/s13054-020-03233-6", "pmid": "32887650", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-020-03233-6"}, {"db": "pmc", "key": "PMC7472408"}], "notes": [], "created": "2020-12-06T07:27:42.373Z", "modified": "2020-12-06T07:27:42.386Z"}, {"entity": "publication", "iuid": "3aa6e6a8aff044aebc36dc62bc8c6b52", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3aa6e6a8aff044aebc36dc62bc8c6b52.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3aa6e6a8aff044aebc36dc62bc8c6b52"}}, "title": "Complicated COVID-19 in pregnancy: a case report with severe liver and coagulation dysfunction promptly improved by delivery.", "authors": [{"family": "Ronnje", "given": "Louise", "initials": "L"}, {"family": "L\u00e4nsberg", "given": "John-Kalle", "initials": "JK"}, {"family": "Vikhareva", "given": "Olga", "initials": "O"}, {"family": "Hansson", "given": "Stefan R", "initials": "SR"}, {"family": "Herbst", "given": "Andreas", "initials": "A"}, {"family": "Zaigham", "given": "Mehreen", "initials": "M"}], "type": "journal article", "published": "2020-09-04", "journal": {"title": "BMC Pregnancy Childbirth", "issn": "1471-2393", "volume": "20", "issue": "1", "pages": "511", "issn-l": null}, "abstract": "It has been proposed that pregnant women and their fetuses may be particularly at risk for poor outcomes due to the coronavirus (COVID-19) pandemic. From the few case series that are available in the literature, women with high risk pregnancies have been associated with higher morbidity. It has been suggested that pregnancy induced immune responses and cardio-vascular changes can exaggerate the course of the COVID-19 infection.\n\nA 26-year old Somalian woman (G2P1) presented with a nine-day history of shortness of breath, dry cough, myalgia, nausea, abdominal pain and fever. A nasopharyngeal swab returned positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Her condition rapidly worsened leading to severe liver and coagulation impairment. An emergency Caesarean section was performed at gestational week 32 + 6 after which the patient made a rapid recovery. Severe COVID-19 promptly improved by the termination of the pregnancy or atypical HELLP (Hemolysis, Elevated Liver Enzymes and Low Platelet Count) exacerbated by concomitant COVID-19 infection could not be ruled out. There was no evidence of vertical transmission.\n\nThis case adds to the growing body of evidence which raises concerns about the possible negative maternal outcomes of COVID-19 infection during pregnancy and advocates for pregnant women to be recognized as a vulnerable group during the current pandemic.", "doi": "10.1186/s12884-020-03172-8", "pmid": "32887569", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12884-020-03172-8"}, {"db": "pmc", "key": "PMC7472409"}], "notes": [], "created": "2020-12-06T07:29:06.065Z", "modified": "2021-02-26T08:45:48.066Z"}, {"entity": "publication", "iuid": "6de1c1add6e94b78b6239f786907ce70", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6de1c1add6e94b78b6239f786907ce70.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6de1c1add6e94b78b6239f786907ce70"}}, "title": "Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline (updated version).", "authors": [{"family": "Jin", "given": "Ying-Hui", "initials": "YH"}, {"family": "Zhan", "given": "Qing-Yuan", "initials": "QY"}, {"family": "Peng", "given": "Zhi-Yong", "initials": "ZY"}, {"family": "Ren", "given": "Xue-Qun", "initials": "XQ"}, {"family": "Yin", "given": "Xun-Tao", "initials": "XT"}, {"family": "Cai", "given": "Lin", "initials": "L"}, {"family": "Yuan", "given": "Yu-Feng", "initials": "YF"}, {"family": "Yue", "given": "Ji-Rong", "initials": "JR"}, {"family": "Zhang", "given": "Xiao-Chun", "initials": "XC"}, {"family": "Yang", "given": "Qi-Wen", "initials": "QW"}, {"family": "Ji", "given": "Jianguang", "initials": "J"}, {"family": "Xia", "given": "Jian", "initials": "J"}, {"family": "Li", "given": "Yi-Rong", "initials": "YR"}, {"family": "Zhou", "given": "Fu-Xiang", "initials": "FX"}, {"family": "Gao", "given": "Ya-Dong", "initials": "YD"}, {"family": "Yu", "given": "Zhui", "initials": "Z"}, {"family": "Xu", "given": "Feng", "initials": "F"}, {"family": "Tu", "given": "Ming-Li", "initials": "ML"}, {"family": "Tan", "given": "Li-Ming", "initials": "LM"}, {"family": "Yang", "given": "Min", "initials": "M"}, {"family": "Chen", "given": "Fang", "initials": "F"}, {"family": "Zhang", "given": "Xiao-Ju", "initials": "XJ"}, {"family": "Zeng", "given": "Mei", "initials": "M"}, {"family": "Zhu", "given": "Yu", "initials": "Y"}, {"family": "Liu", "given": "Xin-Can", "initials": "XC"}, {"family": "Yang", "given": "Jian", "initials": "J"}, {"family": "Zhao", "given": "Dong-Chi", "initials": "DC"}, {"family": "Ding", "given": "Yu-Feng", "initials": "YF"}, {"family": "Hou", "given": "Ning", "initials": "N"}, {"family": "Wang", "given": "Fu-Bing", "initials": "FB"}, {"family": "Chen", "given": "Hao", "initials": "H"}, {"family": "Zhang", "given": "Yong-Gang", "initials": "YG"}, {"family": "Li", "given": "Wei", "initials": "W"}, {"family": "Chen", "given": "Wen", "initials": "W"}, {"family": "Shi", "given": "Yue-Xian", "initials": "YX"}, {"family": "Yang", "given": "Xiu-Zhi", "initials": "XZ"}, {"family": "Wang", "given": "Xue-Jun", "initials": "XJ"}, {"family": "Zhong", "given": "Yan-Jun", "initials": "YJ"}, {"family": "Zhao", "given": "Ming-Juan", "initials": "MJ"}, {"family": "Li", "given": "Bing-Hui", "initials": "BH"}, {"family": "Ma", "given": "Lin-Lu", "initials": "LL"}, {"family": "Zi", "given": "Hao", "initials": "H"}, {"family": "Wang", "given": "Na", "initials": "N"}, {"family": "Wang", "given": "Yun-Yun", "initials": "YY"}, {"family": "Yu", "given": "Shao-Fu", "initials": "SF"}, {"family": "Li", "given": "Lu-Yao", "initials": "LY"}, {"family": "Huang", "given": "Qiao", "initials": "Q"}, {"family": "Weng", "given": "Hong", "initials": "H"}, {"family": "Ren", "given": "Xiang-Ying", "initials": "XY"}, {"family": "Luo", "given": "Li-Sha", "initials": "LS"}, {"family": "Fan", "given": "Man-Ru", "initials": "MR"}, {"family": "Huang", "given": "Di", "initials": "D"}, {"family": "Xue", "given": "Hong-Yang", "initials": "HY"}, {"family": "Yu", "given": "Lin-Xin", "initials": "LX"}, {"family": "Gao", "given": "Jin-Ping", "initials": "JP"}, {"family": "Deng", "given": "Tong", "initials": "T"}, {"family": "Zeng", "given": "Xian-Tao", "initials": "XT", "orcid": "0000-0003-1262-725X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6ac51af3f0b4269b2d7ad82fd726e09.json"}}, {"family": "Li", "given": "Hong-Jun", "initials": "HJ"}, {"family": "Cheng", "given": "Zhen-Shun", "initials": "ZS"}, {"family": "Yao", "given": "Xiaomei", "initials": "X"}, {"family": "Wang", "given": "Xing-Huan", "initials": "XH"}, {"family": "Evidence-Based Medicine Chapter of China International Exchange and Promotive Association for Medical and Health Care (CPAM)", "given": "", "initials": ""}, {"family": "Chinese Research Hospital Association (CRHA)", "given": "", "initials": ""}], "type": "journal article", "published": "2020-09-04", "journal": {"title": "Mil Med Res", "issn": "2054-9369", "volume": "7", "issue": "1", "pages": "41", "issn-l": null}, "abstract": "The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, coronavirus disease 2019 (COVID-19), affecting more than seventeen million people around the world. Diagnosis and treatment guidelines for clinicians caring for patients are needed. In the early stage, we have issued \"A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)\"; now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline. We formed a working group of clinical experts and methodologists. The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas: chemoprophylaxis, diagnosis, treatments, and discharge management. We searched the literature for direct evidence on the management of COVID-19, and assessed its certainty generated recommendations using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Recommendations were either strong or weak, or in the form of ungraded consensus-based statement. Finally, we issued 34 statements. Among them, 6 were strong recommendations for, 14 were weak recommendations for, 3 were weak recommendations against and 11 were ungraded consensus-based statement. They covered topics of chemoprophylaxis (including agents and Traditional Chinese Medicine (TCM) agents), diagnosis (including clinical manifestations, reverse transcription-polymerase chain reaction (RT-PCR), respiratory tract specimens, IgM and IgG antibody tests, chest computed tomography, chest x-ray, and CT features of asymptomatic infections), treatments (including lopinavir-ritonavir, umifenovir, favipiravir, interferon, remdesivir, combination of antiviral drugs, hydroxychloroquine/chloroquine, interleukin-6 inhibitors, interleukin-1 inhibitors, glucocorticoid, qingfei paidu decoction, lianhua qingwen granules/capsules, convalescent plasma, lung transplantation, invasive or noninvasive ventilation, and extracorporeal membrane oxygenation (ECMO)), and discharge management (including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge). We also created two figures of these recommendations for the implementation purpose. We hope these recommendations can help support healthcare workers caring for COVID-19 patients.", "doi": "10.1186/s40779-020-00270-8", "pmid": "32887670", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7472403"}, {"db": "pii", "key": "10.1186/s40779-020-00270-8"}], "notes": [], "created": "2020-12-06T07:27:19.354Z", "modified": "2023-06-19T15:37:30.085Z"}, {"entity": "publication", "iuid": "c405a953cb044229a5b18e6351e3e1fe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c405a953cb044229a5b18e6351e3e1fe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c405a953cb044229a5b18e6351e3e1fe"}}, "title": "An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.", "authors": [{"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Vidakovics Perez", "given": "Laura", "initials": "L"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Das", "given": "Hrishikesh", "initials": "H"}, {"family": "Schulte", "given": "Tim", "initials": "T"}, {"family": "Moliner-Morro", "given": "Ainhoa", "initials": "A"}, {"family": "Corcoran", "given": "Martin", "initials": "M"}, {"family": "Achour", "given": "Adnane", "initials": "A"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "H\u00e4llberg", "given": "B Martin", "initials": "BM"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}], "type": "journal article", "published": "2020-09-04", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "11", "issue": "1", "pages": "4420"}, "abstract": "SARS-CoV-2 enters host cells through an interaction between the spike glycoprotein and the angiotensin converting enzyme 2 (ACE2) receptor. Directly preventing this interaction presents an attractive possibility for suppressing SARS-CoV-2 replication. Here, we report the isolation and characterization of an alpaca-derived single domain antibody fragment, Ty1, that specifically targets the receptor binding domain (RBD) of the SARS-CoV-2 spike, directly preventing ACE2 engagement. Ty1 binds the RBD with high affinity, occluding ACE2. A cryo-electron microscopy structure of the bound complex at 2.9 \u00c5 resolution reveals that Ty1 binds to an epitope on the RBD accessible in both the 'up' and 'down' conformations, sterically hindering RBD-ACE2 binding. While fusion to an Fc domain renders Ty1 extremely potent, Ty1 neutralizes SARS-CoV-2 spike pseudovirus as a 12.8 kDa nanobody, which can be expressed in high quantities in bacteria, presenting opportunities for manufacturing at scale. Ty1 is therefore an excellent candidate as an intervention against COVID-19.", "doi": "10.1038/s41467-020-18174-5", "pmid": "32887876", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: H2020": null, "Category: Biochemistry": null}, "xrefs": [{"db": "GENBANK", "key": "MT784731", "description": "Sequence of Ty1"}, {"db": "URL", "key": "https://github.com/derpaule/Ty1_octet_itc", "description": "ITC data"}, {"db": "URL", "key": "https://github.com/MurrellGroup/Ty1", "description": "Jupyter notebooks to reproduce the NGS data processing"}, {"db": "URL", "key": "https://www.ebi.ac.uk/pdbe/entry/emdb/EMD-11526", "description": "EMDB EMD-11526: Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing nanobodies"}, {"db": "PDB", "key": "6ZXN", "description": "Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing nanobodies (Ty1)"}, {"db": "BioProject", "key": "PRJNA638614", "description": "Next generation sequencing data"}], "notes": [], "created": "2020-10-28T09:09:58.686Z", "modified": "2021-02-26T08:45:03.240Z"}, {"entity": "publication", "iuid": "ed6938f129a644cdb6b4c4b232d3dbd8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed6938f129a644cdb6b4c4b232d3dbd8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed6938f129a644cdb6b4c4b232d3dbd8"}}, "title": "Outcomes of COVID-19 in patients with CLL: a multicenter international experience.", "authors": [{"family": "Mato", "given": "Anthony R", "initials": "AR"}, {"family": "Roeker", "given": "Lindsey E", "initials": "LE"}, {"family": "Lamanna", "given": "Nicole", "initials": "N"}, {"family": "Allan", "given": "John N", "initials": "JN"}, {"family": "Leslie", "given": "Lori", "initials": "L"}, {"family": "Pagel", "given": "John M", "initials": "JM"}, {"family": "Patel", "given": "Krish", "initials": "K"}, {"family": "Osterborg", "given": "Anders", "initials": "A"}, {"family": "Wojenski", "given": "Daniel", "initials": "D"}, {"family": "Kamdar", "given": "Manali", "initials": "M"}, {"family": "Huntington", "given": "Scott F", "initials": "SF"}, {"family": "Davids", "given": "Matthew S", "initials": "MS"}, {"family": "Brown", "given": "Jennifer R", "initials": "JR"}, {"family": "Antic", "given": "Darko", "initials": "D"}, {"family": "Jacobs", "given": "Ryan", "initials": "R"}, {"family": "Ahn", "given": "Inhye E", "initials": "IE"}, {"family": "Pu", "given": "Jeffrey", "initials": "J"}, {"family": "Isaac", "given": "Krista M", "initials": "KM"}, {"family": "Barr", "given": "Paul M", "initials": "PM"}, {"family": "Ujjani", "given": "Chaitra S", "initials": "CS"}, {"family": "Geyer", "given": "Mark B", "initials": "MB"}, {"family": "Berman", "given": "Ellin", "initials": "E"}, {"family": "Zelenetz", "given": "Andrew D", "initials": "AD"}, {"family": "Malakhov", "given": "Nikita", "initials": "N"}, {"family": "Furman", "given": "Richard R", "initials": "RR"}, {"family": "Koropsak", "given": "Michael", "initials": "M"}, {"family": "Bailey", "given": "Neil", "initials": "N"}, {"family": "Hanson", "given": "Lotta", "initials": "L"}, {"family": "Perini", "given": "Guilherme F", "initials": "GF"}, {"family": "Ma", "given": "Shuo", "initials": "S"}, {"family": "Ryan", "given": "Christine E", "initials": "CE"}, {"family": "Wiestner", "given": "Adrian", "initials": "A"}, {"family": "Portell", "given": "Craig A", "initials": "CA"}, {"family": "Shadman", "given": "Mazyar", "initials": "M"}, {"family": "Chong", "given": "Elise A", "initials": "EA"}, {"family": "Brander", "given": "Danielle M", "initials": "DM"}, {"family": "Sundaram", "given": "Suchitra", "initials": "S"}, {"family": "Seddon", "given": "Amanda N", "initials": "AN"}, {"family": "Seymour", "given": "Erlene", "initials": "E"}, {"family": "Patel", "given": "Meera", "initials": "M"}, {"family": "Martinez-Calle", "given": "Nicolas", "initials": "N"}, {"family": "Munir", "given": "Talha", "initials": "T"}, {"family": "Walewska", "given": "Renata", "initials": "R"}, {"family": "Broom", "given": "Angus", "initials": "A"}, {"family": "Walter", "given": "Harriet", "initials": "H"}, {"family": "El-Sharkawi", "given": "Dima", "initials": "D"}, {"family": "Parry", "given": "Helen", "initials": "H"}, {"family": "Wilson", "given": "Matthew R", "initials": "MR"}, {"family": "Patten", "given": "Piers E M", "initials": "PEM"}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jos\u00e9-\u00c1ngel", "initials": "J\u00c1"}, {"family": "Miras", "given": "Fatima", "initials": "F"}, {"family": "Fern\u00e1ndez Escalada", "given": "Noemi", "initials": "N"}, {"family": "Ghione", "given": "Paola", "initials": "P"}, {"family": "Nabhan", "given": "Chadi", "initials": "C"}, {"family": "Lebowitz", "given": "Sonia", "initials": "S"}, {"family": "Bhavsar", "given": "Erica", "initials": "E"}, {"family": "L\u00f3pez-Jim\u00e9nez", "given": "Javier", "initials": "J"}, {"family": "Naya", "given": "Daniel", "initials": "D"}, {"family": "Garcia-Marco", "given": "Jose Antonio", "initials": "JA"}, {"family": "Sk\u00e5nland", "given": "Sigrid S", "initials": "SS"}, {"family": "Cordoba", "given": "Raul", "initials": "R"}, {"family": "Eyre", "given": "Toby A", "initials": "TA"}], "type": "clinical trial", "published": "2020-09-03", "journal": {"title": "Blood", "issn": "1528-0020", "volume": "136", "issue": "10", "pages": "1134-1143", "issn-l": null}, "abstract": "Given advanced age, comorbidities, and immune dysfunction, chronic lymphocytic leukemia (CLL) patients may be at particularly high risk of infection and poor outcomes related to coronavirus disease 2019 (COVID-19). Robust analysis of outcomes for CLL patients, particularly examining effects of baseline characteristics and CLL-directed therapy, is critical to optimally manage CLL patients through this evolving pandemic. CLL patients diagnosed with symptomatic COVID-19 across 43 international centers (n = 198) were included. Hospital admission occurred in 90%. Median age at COVID-19 diagnosis was 70.5 years. Median Cumulative Illness Rating Scale score was 8 (range, 4-32). Thirty-nine percent were treatment naive (\"watch and wait\"), while 61% had received \u22651 CLL-directed therapy (median, 2; range, 1-8). Ninety patients (45%) were receiving active CLL therapy at COVID-19 diagnosis, most commonly Bruton tyrosine kinase inhibitors (BTKi's; n = 68/90 [76%]). At a median follow-up of 16 days, the overall case fatality rate was 33%, though 25% remain admitted. Watch-and-wait and treated cohorts had similar rates of admission (89% vs 90%), intensive care unit admission (35% vs 36%), intubation (33% vs 25%), and mortality (37% vs 32%). CLL-directed treatment with BTKi's at COVID-19 diagnosis did not impact survival (case fatality rate, 34% vs 35%), though the BTKi was held during the COVID-19 course for most patients. These data suggest that the subgroup of CLL patients admitted with COVID-19, regardless of disease phase or treatment status, are at high risk of death. Future epidemiologic studies are needed to assess severe acute respiratory syndrome coronavirus 2 infection risk, these data should be validated independently, and randomized studies of BTKi's in COVID-19 are needed to provide definitive evidence of benefit.", "doi": "10.1182/blood.2020006965", "pmid": "32688395", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "461426"}, {"db": "pmc", "key": "PMC7472711"}], "notes": [], "created": "2020-12-07T16:30:16.839Z", "modified": "2021-02-26T08:45:03.331Z"}, {"entity": "publication", "iuid": "7b945315d0934beba3a131f7efdb347c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b945315d0934beba3a131f7efdb347c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b945315d0934beba3a131f7efdb347c"}}, "title": "Inadequate prophylactic effect of low-molecular weight heparin in critically ill COVID-19 patients.", "authors": [{"family": "Stattin", "given": "K", "initials": "K"}, {"family": "Lipcsey", "given": "M", "initials": "M"}, {"family": "Andersson", "given": "H", "initials": "H"}, {"family": "Pont\u00e9n", "given": "E", "initials": "E"}, {"family": "B\u00fclow Anderberg", "given": "S", "initials": "S"}, {"family": "Gradin", "given": "A", "initials": "A"}, {"family": "Larsson", "given": "A", "initials": "A"}, {"family": "Lubenow", "given": "N", "initials": "N"}, {"family": "von Seth", "given": "M", "initials": "M"}, {"family": "Rubertsson", "given": "S", "initials": "S"}, {"family": "Hultstr\u00f6m", "given": "M", "initials": "M"}, {"family": "Frithiof", "given": "R", "initials": "R"}], "type": "journal article", "published": "2020-09-03", "journal": {"title": "J Crit Care", "issn": "1557-8615", "issn-l": "0883-9441", "volume": "60", "issue": null, "pages": "249-252"}, "abstract": "The aim of this study was to investigate potential markers of coagulopathy and the effects of thromboprophylaxis with low-molecular-weight heparin (LMWH) on thromboelastography (TEG) and anti-factor Xa in critically ill COVID-19 patients.\r\n\r\nWe conducted a prospective study in 31 consecutive adult intensive care unit (ICU) patients. TEG with and without heparinase and anti-factor Xa analysis were performed. Standard thromboprophylaxis was given with dalteparin (75-100 IU/kg subcutaneously).\r\n\r\nFive patients (16%) had symptomatic thromboembolic events. All patients had a maximum amplitude (MA) > 65 mm and 13 (42%) had MA > 72 mm at some point during ICU stay. Anti-factor Xa activity were below the target range in 23% of the patients and above target range in 46% of patients. There was no significant correlation between dalteparin dose and anti-factor Xa activity.\r\n\r\nPatients with COVID-19 have hypercoagulability with high MA on TEG. The effect of LMWH on thromboembolic disease, anti-factor Xa activity and TEG was variable and could not be reliably predicted. This indicates that standard prophylactic doses of LMWH may be insufficient. Monitoring coagulation and the LMWH effect is important in patients with COVID-19 but interpreting the results in relation to risk of thromboembolic disease poses difficulties.", "doi": "10.1016/j.jcrc.2020.08.026", "pmid": "32920503", "labels": {"Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-04T15:28:40.388Z", "modified": "2021-02-26T08:45:48.368Z"}, {"entity": "publication", "iuid": "e9ec5321a98b4d0a8c212629069c6a8a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e9ec5321a98b4d0a8c212629069c6a8a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e9ec5321a98b4d0a8c212629069c6a8a"}}, "title": "Factors contributing to healthcare professional burnout during the COVID-19 pandemic: A rapid turnaround global survey", "authors": [{"family": "Morgantini", "given": "Luca A", "initials": "LA"}, {"family": "Naha", "given": "Ushasi", "initials": "U"}, {"family": "Wang", "given": "Heng", "initials": "H"}, {"family": "Francavilla", "given": "Simone", "initials": "S"}, {"family": "Acar", "given": "\u00d6mer", "initials": "\u00d6"}, {"family": "Flores", "given": "Jose M", "initials": "JM"}, {"family": "Crivellaro", "given": "Simone", "initials": "S"}, {"family": "Moreira", "given": "Daniel", "initials": "D"}, {"family": "Abern", "given": "Michael", "initials": "M"}, {"family": "Eklund", "given": "Martin", "initials": "M"}, {"family": "Vigneswaran", "given": "Hari T", "initials": "HT"}, {"family": "Weine", "given": "Stevan M", "initials": "SM"}], "type": "journal-article", "published": "2020-09-03", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "15", "issue": "9", "pages": "e0238217", "issn-l": "1932-6203"}, "abstract": null, "doi": "10.1371/journal.pone.0238217", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.1371/journal.pone.0238217.s006", "description": "Individual-level data on exposure, perception, and workload collected from 2,707 healthcare professionals from 60 countries"}], "notes": [], "created": "2021-01-26T15:12:12.627Z", "modified": "2021-02-26T08:47:00.279Z"}, {"entity": "publication", "iuid": "19e9898a4a93451b8319e13cc3ea055f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19e9898a4a93451b8319e13cc3ea055f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19e9898a4a93451b8319e13cc3ea055f"}}, "title": "COVID-19 pandemic: implementing control measures in Africa using the 'SHEF2' model.", "authors": [{"family": "Wirsiy", "given": "Frankline Sevidzem", "initials": "FS"}, {"family": "Nkfusai", "given": "Claude Ngwayu", "initials": "CN"}, {"family": "Ako-Arrey", "given": "Denis Ebot", "initials": "DE"}, {"family": "Yeika", "given": "Eugene Vernyuy", "initials": "EV"}, {"family": "Manjong", "given": "Florence Titu", "initials": "FT"}, {"family": "Esther", "given": "Dongmo Kenfack", "initials": "DK"}, {"family": "Nzoyom", "given": "Rosette Boseme", "initials": "RB"}, {"family": "Atuhaire", "given": "Catherine", "initials": "C"}, {"family": "Wirsiy", "given": "Jean-Claude Kindzeka", "initials": "JK"}, {"family": "Cumber", "given": "Samuel Nambile", "initials": "SN"}], "type": "journal article", "published": "2020-09-03", "journal": {"title": "Pan Afr Med J", "issn": "1937-8688", "volume": "37", "issue": "Suppl 1", "pages": "3", "issn-l": null}, "abstract": "The COVID-19 Pandemic in Africa is a severe reminder of the brunt of emerging and re-emerging infectious pathogens and the need for simple, context-oriented, and sustainable health models to combat them when the need arises. In this commentary, an analytical discursive approach was chosen to owe to Africa's unique situation of weak health systems, with most of its member states showing an initial reluctance to deal openly with the COVID-19 situation. This paper discusses five major control measures doped the SHEF2 Model i.e. (\"SHEF2\"- S: Social distancing, H: Hands, E: Elbows, F: Face, F: Feel) of COVID-19 implemented in Africa. We also review the issues related to implementing SHEF2 control measures in Africa. The measures being taken in Asia, Europe, and North America such as social distancing and regular hand washing are a particular challenge for African countries with dense populations, unequal access to water, and limited social safety nets. COVID-19 is challenging the public health and socio-political systems of all affected African countries. The burden of COVID-19 demands rapid and decisive action to be taken, yet the comparison shows how difficult it is was for an unknown new coronavirus disease. In line with the steps being taken across the globe to control and contain COVID-19 pandemic, African countries are preparing for the great effects of this pandemic and ensuing deep recession thus the reason we assert, the greater hope for African countries is implementing an aggressive SHEF2 model strategy. The spread of the pandemic will eventually stop, and the international system will find a balance, but most of the damage will be felt particularly by Africa.", "doi": "10.11604/pamj.supp.2020.37.3.24057", "pmid": "33294104", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "PAMJ-37-1-3"}, {"db": "pmc", "key": "PMC7704345"}], "notes": [], "created": "2020-12-10T09:11:44.724Z", "modified": "2020-12-10T09:13:01.588Z"}, {"entity": "publication", "iuid": "60868faf0ee247319d300b5aaf777e16", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60868faf0ee247319d300b5aaf777e16.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60868faf0ee247319d300b5aaf777e16"}}, "title": "A Thematic Analysis of Weibo Topics (Chinese Twitter Hashtags) regarding Older Adults During the COVID-19 Outbreak.", "authors": [{"family": "Xi", "given": "Wanyu", "initials": "W"}, {"family": "Xu", "given": "Wenqian", "initials": "W"}, {"family": "Zhang", "given": "Xin", "initials": "X"}, {"family": "Ayalon", "given": "Liat", "initials": "L"}], "type": "journal article", "published": "2020-09-03", "journal": {"title": "J Gerontol B Psychol Sci Soc Sci", "issn": "1758-5368", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "We explored the portrayal of older adults and the public response to topics concerning older adults during the COVID-19 pandemic in Chinese social media (Weibo topics, equivalent to hashtags on Twitter). We also explored the temporal trends of dominant themes to identify changes over time.\r\n\r\nTopics related to older adults were searched in the Weibo topic search engine between January 20 and April 28, 2020. Overall, 241 topics and their view frequency and comment frequency were collected. Inductive thematic analysis was conducted to classify the topics into themes. The popularity of each theme was also analyzed. In addition, the frequency with which each theme appeared during the three major stages of the pandemic (outbreak, turnover, post-peak) was reported.\r\n\r\nSix main themes were identified. \"Older adults contributing to the community\" was the most prominent theme with the highest average comment frequency per topic. It was also the most dominant theme in the first stage of the pandemic. \"Older patients in hospitals\" was the second most prominent theme, and the most dominant theme in the second and third stages of the pandemic. The percentage of topics with the themes \"Care recipients\" and \"Older adults caring for the young\" increased over time.\r\n\r\nThe portrayal of older people as being warm, competent, and actively exercising their agency is prevalent on Weibo. The Weibo-viewing public shows signs of interest in intergenerational solidarity during the pandemic in China. These findings are different from findings reported by studies conducted in the West.", "doi": "10.1093/geronb/gbaa148", "pmid": "32882029", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "5901075"}, {"db": "pmc", "key": "PMC7499682"}], "notes": [], "created": "2020-12-06T07:31:38.507Z", "modified": "2022-11-10T06:42:21.409Z"}, {"entity": "publication", "iuid": "b117f2dd395849ec983cbe9cebb6bedd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b117f2dd395849ec983cbe9cebb6bedd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b117f2dd395849ec983cbe9cebb6bedd"}}, "title": "Rhabdomyolysis and acute kidney injury in severe COVID-19 infection.", "authors": [{"family": "Taxbro", "given": "Knut", "initials": "K"}, {"family": "Kahlow", "given": "Hannes", "initials": "H"}, {"family": "Wulcan", "given": "Hannes", "initials": "H"}, {"family": "Fornarve", "given": "Anna", "initials": "A"}], "type": "case reports", "published": "2020-09-02", "journal": {"title": "BMJ Case Rep", "issn": "1757-790X", "volume": "13", "issue": "9", "issn-l": null}, "abstract": "We report the case of a 38-year-old man who presented to the emergency department with fever, myalgia, nausea, vomiting, dry cough, breathlessness and abdominal pain. He was admitted due to hypoxaemia and was diagnosed with SARS-CoV-2 and was subsequently referred to the intensive care unit for intubation and mechanical ventilation. Severe rhabdomyolysis and acute kidney injury developed 4 days later and were suspected after noticing discolouration of the urine and a marked increase in plasma myoglobin levels. Treatment included hydration, forced diuresis and continuous renal replacement therapy. In addition to the coronavirus disease acute respiratory distress syndrome, he was diagnosed with possible SARS-CoV-2-induced myositis with severe rhabdomyolysis and kidney failure. The patient survived and was discharged from intensive care after 12 days, returning home 23 days after hospitalisation, fully mobilised with a partially restored kidney function.", "doi": "10.1136/bcr-2020-237616", "pmid": "32878841", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "13/9/e237616"}, {"db": "pmc", "key": "PMC7470512"}], "notes": [], "created": "2020-12-06T07:33:40.982Z", "modified": "2021-02-26T08:45:48.586Z"}, {"entity": "publication", "iuid": "70967c8fd05941d09e83d78ea1c0a572", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70967c8fd05941d09e83d78ea1c0a572.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70967c8fd05941d09e83d78ea1c0a572"}}, "title": "Implementation researchers can improve the responses of services to the COVID-19 pandemic.", "authors": [{"family": "\u00d8vretveit", "given": "John", "initials": "J"}], "type": "journal article", "published": "2020-09-02", "journal": {"title": "Implement Res Pract", "issn": "2633-4895", "volume": "1", "pages": "2633489520949151", "issn-l": null}, "abstract": "This article describes a rapid implementation research project with the Stockholm health care system to assist the system to respond to the COVID-19 pandemic. It uses this example to illustrate some ways in which implementation research and knowledge can contribute to improving service responses to the pandemic and its consequences as these evolve over the coming months. A sub-specialty of rapid implementation science is proposed to provide practical assistance and as one way to develop implementation research.\n\nThis article describes a rapid implementation research project with the Stockholm health care system to assist the system to respond to the COVID-19 pandemic. It uses this example to illustrate some ways in which implementation research and knowledge can contribute to improving service responses to the pandemic and its consequences as these evolve over the coming months. A sub-specialty of rapid implementation science is proposed to provide practical assistance and as one way to develop implementation research.", "doi": "10.1177/2633489520949151", "pmid": "34192265", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1177_2633489520949151"}, {"db": "pmc", "key": "PMC7468666"}], "notes": [], "created": "2021-07-05T14:27:05.143Z", "modified": "2021-07-05T14:27:05.167Z"}, {"entity": "publication", "iuid": "e759bb7be15443c9ada587d3b408877b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e759bb7be15443c9ada587d3b408877b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e759bb7be15443c9ada587d3b408877b"}}, "title": "Excess cardiovascular deaths in the beginning of COVID-19 outbreak", "authors": [{"family": "Wang", "given": "Junren", "initials": "J"}, {"family": "Zhu", "given": "Jianwei", "initials": "J"}, {"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Sun", "given": "Yajing", "initials": "Y"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "Qu", "given": "Yuanyuan", "initials": "Y"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "posted-content", "published": "2020-09-02", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.08.29.20184317", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-09T19:23:35.863Z", "modified": "2021-06-09T19:23:56.032Z"}, {"entity": "publication", "iuid": "2bc302a6f4a44f5d87ded89cf06c3b6e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2bc302a6f4a44f5d87ded89cf06c3b6e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2bc302a6f4a44f5d87ded89cf06c3b6e"}}, "title": "Coronavirus Disease 2019 Related Clinical Studies: A Cross-Sectional Analysis.", "authors": [{"family": "Ma", "given": "Lin-Lu", "initials": "LL"}, {"family": "Yin", "given": "Xuan", "initials": "X"}, {"family": "Li", "given": "Bing-Hui", "initials": "BH"}, {"family": "Yang", "given": "Jia-Yu", "initials": "JY"}, {"family": "Jin", "given": "Ying-Hui", "initials": "YH"}, {"family": "Huang", "given": "Di", "initials": "D"}, {"family": "Deng", "given": "Tong", "initials": "T"}, {"family": "Wang", "given": "Yun-Yun", "initials": "YY"}, {"family": "Ren", "given": "Xue-Qun", "initials": "XQ"}, {"family": "Ji", "given": "Jianguang", "initials": "J"}, {"family": "Zeng", "given": "Xian-Tao", "initials": "XT"}], "type": "journal article", "published": "2020-09-02", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "11", "issue": null, "pages": "540187", "issn-l": "1663-9812"}, "abstract": "The quality and rationality of many recently registered clinical studies related to coronavirus disease 2019 (COVID-19) needs to be assessed. Hence, this study aims to evaluate the current status of COVID-19 related registered clinical trial.\n\nWe did an electronic search of COVID-19 related clinical studies registered between December 1, 2019 and February 21, 2020 (updated to May 28, 2020) from the ClinicalTrials.gov, and collected registration information, study details, recruitment status, characteristics of the subjects, and relevant information about the trial implementation process.\n\nA total of 1,706 studies were included 10.0% of which (n=171) were from France, 943 (55.3%) used an interventional design, and 600 (35.2%) used an observational design. Most of studies (73.6%) aimed to recruit fewer than 500 people. Interferon was the main prevention program, and antiviral drugs were the main treatment program. Hydroxychloroquine and chloroquine (230/943, 24.4%) were widely studied. Some registered clinical trials are incomplete in content, and 37.4% of the 1,706 studies may have had insufficient sample size.\n\nThe quality of COVID-19 related studies needs to be improved by strengthening the registration process and improving the quality of clinical study protocols so that these clinical studies can provide high-quality clinical evidence related to COVID-19.", "doi": "10.3389/fphar.2020.540187", "pmid": "32982751", "labels": {"Type: Journal article": null, "Category: Imaging": null}, "xrefs": [{"db": "pmc", "key": "PMC7492524"}], "notes": [], "created": "2020-12-03T09:36:21.593Z", "modified": "2021-02-26T08:45:36.589Z"}, {"entity": "publication", "iuid": "03ecaaa4c4644762a6707bfd95b232a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/03ecaaa4c4644762a6707bfd95b232a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/03ecaaa4c4644762a6707bfd95b232a6"}}, "title": "Oxytocin's anti-inflammatory and proimmune functions in COVID-19: a transcriptomic signature-based approach.", "authors": [{"family": "Imami", "given": "Ali S", "initials": "AS"}, {"family": "O'Donovan", "given": "Sinead M", "initials": "SM"}, {"family": "Creeden", "given": "Justin F", "initials": "JF"}, {"family": "Wu", "given": "Xiaojun", "initials": "X"}, {"family": "Eby", "given": "Hunter", "initials": "H"}, {"family": "McCullumsmith", "given": "Cheryl B", "initials": "CB"}, {"family": "Uvn\u00e4s-Moberg", "given": "Kerstin", "initials": "K"}, {"family": "McCullumsmith", "given": "Robert E", "initials": "RE"}, {"family": "Andari", "given": "Elissar", "initials": "E"}], "type": "journal article", "published": "2020-09-01", "journal": {"title": "Physiol Genomics", "issn": "1531-2267", "volume": "52", "issue": "9", "pages": "401-407", "issn-l": null}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide pandemic, infecting over 16 million people worldwide with a significant mortality rate. However, there is no current Food and Drug Administration-approved drug that treats coronavirus disease 2019 (COVID-19). Damage to T lymphocytes along with the cytokine storm are important factors that lead to exacerbation of clinical cases. Here, we are proposing intravenous oxytocin (OXT) as a candidate for adjunctive therapy for COVID-19. OXT has anti-inflammatory and proimmune adaptive functions. Using the Library of Integrated Network-Based Cellular Signatures (LINCS), we used the transcriptomic signature for carbetocin, an OXT agonist, and compared it to gene knockdown signatures of inflammatory (such as interleukin IL-1\u03b2 and IL-6) and proimmune markers (including T cell and macrophage cell markers like CD40 and ARG1). We found that carbetocin's transcriptomic signature has a pattern of concordance with inflammation and immune marker knockdown signatures that are consistent with reduction of inflammation and promotion and sustaining of immune response. This suggests that carbetocin may have potent effects in modulating inflammation, attenuating T cell inhibition, and enhancing T cell activation. Our results also suggest that carbetocin is more effective at inducing immune cell responses than either lopinavir or hydroxychloroquine, both of which have been explored for the treatment of COVID-19.", "doi": "10.1152/physiolgenomics.00095.2020", "pmid": "32809918", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2020-12-07T12:49:51.761Z", "modified": "2021-02-26T08:45:02.813Z"}, {"entity": "publication", "iuid": "7325494cd545495586695b3c740af140", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7325494cd545495586695b3c740af140.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7325494cd545495586695b3c740af140"}}, "title": "Outcomes of renin-angiotensin-aldosterone system blockers in patients with COVID-19: a systematic review and meta-analysis.", "authors": [{"family": "Greco", "given": "Antonio", "initials": "A"}, {"family": "Buccheri", "given": "Sergio", "initials": "S"}, {"family": "D'Arrigo", "given": "Paolo", "initials": "P"}, {"family": "Calderone", "given": "Dario", "initials": "D"}, {"family": "Agnello", "given": "Federica", "initials": "F"}, {"family": "Monte", "given": "Marco", "initials": "M"}, {"family": "Milluzzo", "given": "Rocco Paolo", "initials": "RP"}, {"family": "Franchina", "given": "Antonio Gabriele", "initials": "AG"}, {"family": "Ingala", "given": "Salvatore", "initials": "S"}, {"family": "Capodanno", "given": "Davide", "initials": "D"}], "type": "letter", "published": "2020-09-01", "journal": {"title": "Eur Heart J Cardiovasc Pharmacother", "issn": "2055-6845", "volume": "6", "issue": "5", "pages": "335-337", "issn-l": "2055-6837"}, "abstract": null, "doi": "10.1093/ehjcvp/pvaa074", "pmid": "32671399", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "5872101"}, {"db": "pmc", "key": "PMC7454531"}], "notes": [], "created": "2020-11-22T09:22:06.498Z", "modified": "2020-11-30T08:45:14.800Z"}, {"entity": "publication", "iuid": "a664bb8435df4fddb58e270ad7c8b581", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a664bb8435df4fddb58e270ad7c8b581.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a664bb8435df4fddb58e270ad7c8b581"}}, "title": "Explaining the homogeneous diffusion of COVID-19 nonpharmaceutical interventions across heterogeneous countries.", "authors": [{"family": "Sebhatu", "given": "Abiel", "initials": "A"}, {"family": "Wennberg", "given": "Karl", "initials": "K"}, {"family": "Arora-Jonsson", "given": "Stefan", "initials": "S"}, {"family": "Lindberg", "given": "Staffan I", "initials": "SI"}], "type": "journal article", "published": "2020-09-01", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "issn-l": "0027-8424", "volume": "117", "issue": "35", "pages": "21201-21208"}, "abstract": "We analyze the adoption of nonpharmaceutical interventions in the Organisation for Economic Co-operation and Development (OECD) countries during the early phase of the coronavirus disease 2019 (COVID-19) pandemic. Given the complexity associated with pandemic decisions, governments are faced with the dilemma of how to act quickly when their core decision-making processes are based on deliberations balancing political considerations. Our findings show that, in times of severe crisis, governments follow the lead of others and base their decisions on what other countries do. Governments in countries with a stronger democratic structure are slower to react in the face of the pandemic but are more sensitive to the influence of other countries. We provide insights for research on international policy diffusion and research on the political consequences of the COVID-19 pandemic.", "doi": "10.1073/pnas.2010625117", "pmid": "32788356", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "2010625117"}, {"db": "pmc", "key": "PMC7474611"}], "notes": [], "created": "2020-11-19T15:05:37.246Z", "modified": "2022-11-10T06:43:30.755Z"}, {"entity": "publication", "iuid": "6e911372463547cb80b4199fe05ce8f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e911372463547cb80b4199fe05ce8f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e911372463547cb80b4199fe05ce8f4"}}, "title": "Effects of COVID-19 lockdown strategies on management of atrial fibrillation.", "authors": [{"family": "Blomstr\u00f6m-Lundqvist", "given": "Carina", "initials": "C"}], "type": "editorial", "published": "2020-09-01", "journal": {"title": "Eur Heart J", "issn": "1522-9645", "volume": "41", "issue": "32", "pages": "3080-3082", "issn-l": "0195-668X"}, "abstract": "Editorial", "doi": "10.1093/eurheartj/ehaa538", "pmid": "32614939", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5866605"}, {"db": "pmc", "key": "PMC7528957"}], "notes": [], "created": "2020-11-22T08:48:19.135Z", "modified": "2020-12-08T15:07:44.115Z"}, {"entity": "publication", "iuid": "7ae6940fde8344e3bbf1e8e26cebc2d6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7ae6940fde8344e3bbf1e8e26cebc2d6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7ae6940fde8344e3bbf1e8e26cebc2d6"}}, "title": "COVID-19: how things change in a short while.", "authors": [{"family": "Stolfo", "given": "Davide", "initials": "D"}, {"family": "Sinagra", "given": "Gianfranco", "initials": "G"}], "type": "journal article", "published": "2020-09-01", "journal": {"title": "Eur Heart J Cardiovasc Pharmacother", "issn": "2055-6845", "volume": "6", "issue": "5", "pages": "280-281", "issn-l": "2055-6837"}, "abstract": null, "doi": "10.1093/ehjcvp/pvaa092", "pmid": "32678899", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5873153"}, {"db": "pmc", "key": "PMC7454535"}], "notes": [], "created": "2020-12-07T16:34:29.256Z", "modified": "2020-12-07T16:34:29.265Z"}, {"entity": "publication", "iuid": "90ec8d01daeb4319862104f8d124424f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90ec8d01daeb4319862104f8d124424f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90ec8d01daeb4319862104f8d124424f"}}, "title": "Avoiding the Banality of Evil in Times of COVID-19: Thinking Differently with a Biopsychosocial Perspective for Future Health and Social Policies Development.", "authors": [{"family": "Leonardi", "given": "Matilde", "initials": "M"}, {"family": "Lee", "given": "Haejung", "initials": "H"}, {"family": "van der Veen", "given": "Sabina", "initials": "S"}, {"family": "Maribo", "given": "Thomas", "initials": "T"}, {"family": "Cuenot", "given": "Marie", "initials": "M"}, {"family": "Simon", "given": "Liane", "initials": "L"}, {"family": "Paltamaa", "given": "Jaana", "initials": "J"}, {"family": "Maart", "given": "Soraya", "initials": "S"}, {"family": "Tucker", "given": "Carole", "initials": "C"}, {"family": "Besstrashnova", "given": "Yanina", "initials": "Y"}, {"family": "Shosmin", "given": "Alexander", "initials": "A"}, {"family": "Cid", "given": "Daniel", "initials": "D"}, {"family": "Almborg", "given": "Ann-Helene", "initials": "AH"}, {"family": "Anttila", "given": "Heidi", "initials": "H"}, {"family": "Yamada", "given": "Shin", "initials": "S"}, {"family": "Frattura", "given": "Lucilla", "initials": "L"}, {"family": "Zavaroni", "given": "Carlo", "initials": "C"}, {"family": "Zhuoying", "given": "Qiu", "initials": "Q"}, {"family": "Martinuzzi", "given": "Andrea", "initials": "A"}, {"family": "Martinuzzi", "given": "Michela", "initials": "M"}, {"family": "Magnani", "given": "Francesca Giulia", "initials": "FG"}, {"family": "Snyman", "given": "Stefanus", "initials": "S"}, {"family": "El Oumri", "given": "Ahmed Amine", "initials": "AA"}, {"family": "Sylvain", "given": "Ndegeya", "initials": "N"}, {"family": "Layton", "given": "Natasha", "initials": "N"}, {"family": "Sykes", "given": "Catherine", "initials": "C"}, {"family": "Saleeby", "given": "Patricia Welch", "initials": "PW"}, {"family": "Winkler", "given": "Andrea Sylvia", "initials": "AS"}, {"family": "de Camargo", "given": "Olaf Kraus", "initials": "OK"}], "type": "journal article", "published": "2020-09-01", "journal": {"title": "SN Compr Clin Med", "issn": "2523-8973", "volume": null, "issue": null, "pages": "1-3", "issn-l": null}, "abstract": "The COVID-19 pandemic provides the opportunity to re-think health policies and health systems approaches by the adoption of a biopsychosocial perspective, thus acting on environmental factors so as to increase facilitators and diminish barriers. Specifically, vulnerable people should not face discrimination because of their vulnerability in the allocation of care or life-sustaining treatments. Adoption of biopsychosocial model helps to identify key elements where to act to diminish effects of the pandemics. The pandemic showed us that barriers in health care organization affect mostly those that are vulnerable and can suffer discrimination not because of severity of diseases but just because of their vulnerability, be this age or disability and this can be avoided by biopsychosocial planning in health and social policies. It is possible to avoid the banality of evil, intended as lack of thinking on what we do when we do, by using the emergence of the emergency of COVID-19 as a Trojan horse to achieve some of the sustainable development goals such as universal health coverage and equity in access, thus acting on environmental factors is the key for global health improvement.", "doi": "10.1007/s42399-020-00486-8", "pmid": "32905109", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "486"}, {"db": "pmc", "key": "PMC7462656"}], "notes": [], "created": "2020-12-03T15:54:02.093Z", "modified": "2020-12-03T15:54:02.118Z"}, {"entity": "publication", "iuid": "70b2e65b6cd84e38a2b89ed18da66416", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70b2e65b6cd84e38a2b89ed18da66416.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70b2e65b6cd84e38a2b89ed18da66416"}}, "title": "Association between eating behavior and quarantine/confinement stressors during the coronavirus disease 2019 outbreak.", "authors": [{"family": "Haddad", "given": "Chadia", "initials": "C"}, {"family": "Zakhour", "given": "Maha", "initials": "M"}, {"family": "Bou Kheir", "given": "Maria", "initials": "M"}, {"family": "Haddad", "given": "Rima", "initials": "R"}, {"family": "Al Hachach", "given": "Myriam", "initials": "M"}, {"family": "Sacre", "given": "Hala", "initials": "H"}, {"family": "Salameh", "given": "Pascale", "initials": "P"}], "type": "journal article", "published": "2020-09-01", "journal": {"title": "J Eat Disord", "issn": "2050-2974", "issn-l": null, "volume": "8", "issue": null, "pages": "40"}, "abstract": "Quarantine/confinement is an effective measure to face the Coronavirus disease 2019 (COVID-19). Consequently, in response to this stressful situation, people confined to their homes may change their everyday eating behavior. Therefore, the primary objective of this study is to evaluate the association between quarantine/confinement stressors and eating behavior during the COVID-19 outbreak. The secondary objective is to compare the association of quarantine/confinement stressors and diet behavior between two groups of participants, those attending diet clinics and those not (general population).\r\n\r\nA cross-sectional web-based online survey carried out between April 3 and 18, 2020, enrolled 407 participants from the Lebanese population. Eating Disorder Examination - Questionnaire (EDE-Q) were used to measure the behavioral features of eating disorders.\r\n\r\nMore than half of the sample (53.0%) abide by the home quarantine/confinement, 95.4% were living with someone in the quarantine/confinement, and 39.6% continued to work from home. Higher fear of COVID-19 was found in 182 (44.8%) participants, higher boredom in 200 (49.2%) participants, higher anger in 187 (46.3%), and higher anxiety in 197 (48.5%) participants. Higher fear of COVID-19 (Beta = 0.02), higher BMI (Beta = 0.05), and physical activity (Beta = 1.04) were significantly associated with a higher restraint score. Higher anxiety, higher fear of COVID-19, higher BMI, practicing physical exercise, and a higher number of adults living in the quarantine/confinement were significantly associated with higher shape and weight concerns.\r\n\r\nOur results showed that the fear of COVID-19 was correlated with more eating restraint, weight, and shape concerns in the whole sample, but more specifically in the dietitian clients group. Public health control measures are needed to reduce the detrimental effects of psychological distress associated with quarantine/confinement on eating behaviors during the COVID-19 outbreak.", "doi": "10.1186/s40337-020-00317-0", "pmid": "32879730", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "317"}, {"db": "pmc", "key": "PMC7458649"}], "notes": [], "created": "2020-12-06T07:32:44.998Z", "modified": "2022-11-10T06:47:03.755Z"}, {"entity": "publication", "iuid": "a8d0a2f042ac48f8ab2a981f039d2479", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8d0a2f042ac48f8ab2a981f039d2479.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8d0a2f042ac48f8ab2a981f039d2479"}}, "title": "Vitamin D deficiency and the COVID-19 pandemic.", "authors": [{"family": "Zemb", "given": "Patrick", "initials": "P"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Camargo", "given": "Carlos A", "initials": "CA"}, {"family": "Cavalier", "given": "Etienne", "initials": "E"}, {"family": "Cormier", "given": "Catherine", "initials": "C"}, {"family": "Courbebaisse", "given": "Marie", "initials": "M"}, {"family": "Hollis", "given": "Bruce", "initials": "B"}, {"family": "Joulia", "given": "Fabrice", "initials": "F"}, {"family": "Minisola", "given": "Salvatore", "initials": "S"}, {"family": "Pilz", "given": "Stefan", "initials": "S"}, {"family": "Pludowski", "given": "Pawel", "initials": "P"}, {"family": "Schmitt", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Zdrenghea", "given": "Mihnea", "initials": "M"}, {"family": "Souberbielle", "given": "Jean-Claude", "initials": "JC"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "J Glob Antimicrob Resist", "issn": "2213-7173", "volume": "22", "issue": null, "pages": "133-134", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jgar.2020.05.006", "pmid": "32474141", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-7165(20)30132-6"}, {"db": "pmc", "key": "PMC7256612"}], "notes": [], "created": "2020-12-09T10:59:00.344Z", "modified": "2020-12-09T10:59:00.366Z"}, {"entity": "publication", "iuid": "b1573fb6875347c485fd5af422886c13", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1573fb6875347c485fd5af422886c13.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1573fb6875347c485fd5af422886c13"}}, "title": "Travel-associated COVID-19: a challenge for surveillance?", "authors": [{"family": "Beaut\u00e9", "given": "Julien", "initials": "J"}, {"family": "Spiteri", "given": "Gianfranco", "initials": "G"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "37", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.37.2001641", "pmid": "32945253", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7502887"}], "notes": [], "created": "2020-12-03T15:26:13.762Z", "modified": "2020-12-03T15:26:13.772Z"}, {"entity": "publication", "iuid": "c168f9f298ba441cb13488e8fa8a9709", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c168f9f298ba441cb13488e8fa8a9709.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c168f9f298ba441cb13488e8fa8a9709"}}, "title": "Transmission of SARS-CoV-2 in children aged 0 to 19 years in childcare facilities and schools after their reopening in May 2020, Baden-W\u00fcrttemberg, Germany.", "authors": [{"family": "Ehrhardt", "given": "J", "initials": "J"}, {"family": "Ekinci", "given": "A", "initials": "A"}, {"family": "Krehl", "given": "H", "initials": "H"}, {"family": "Meincke", "given": "M", "initials": "M"}, {"family": "Finci", "given": "I", "initials": "I"}, {"family": "Klein", "given": "J", "initials": "J"}, {"family": "Geisel", "given": "B", "initials": "B"}, {"family": "Wagner-Wiening", "given": "C", "initials": "C"}, {"family": "Eichner", "given": "M", "initials": "M"}, {"family": "Brockmann", "given": "S O", "initials": "SO"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "36", "issn-l": null}, "abstract": "We investigated data from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected 0-19 year olds, who attended schools/childcare facilities, to assess their role in SARS-CoV-2 transmission after these establishments' reopening in May 2020 in Baden-W\u00fcrttemberg, Germany. Child-to-child transmission in schools/childcare facilities appeared very uncommon. We anticipate that, with face mask use and frequent ventilation of rooms, transmission rates in schools/childcare facilities would remain low in the next term, even if classes' group sizes were increased.", "doi": "10.2807/1560-7917.ES.2020.25.36.2001587", "pmid": "32914746", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7502898"}], "notes": [], "created": "2020-12-03T15:49:58.334Z", "modified": "2021-02-26T08:45:48.653Z"}, {"entity": "publication", "iuid": "88f2b1b690ab477d9fe2589437f08ec1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/88f2b1b690ab477d9fe2589437f08ec1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/88f2b1b690ab477d9fe2589437f08ec1"}}, "title": "Towards pandemic preparedness beyond COVID-19", "authors": [{"family": "Naguib", "given": "Mahmoud M", "initials": "MM"}, {"family": "Ellstr\u00f6m", "given": "Patrik", "initials": "P"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Olsen", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal-article", "published": "2020-09-00", "journal": {"title": "The Lancet Microbe", "issn": "2666-5247", "issn-l": "2666-5247", "volume": "1", "issue": "5", "pages": "e185-e186"}, "abstract": "Review", "doi": "10.1016/s2666-5247(20)30088-4", "pmid": "32838347", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-04T07:08:50.155Z", "modified": "2020-12-11T12:51:10.950Z"}, {"entity": "publication", "iuid": "a9b3c57bb27342faaaa07bd80d8ed5c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a9b3c57bb27342faaaa07bd80d8ed5c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a9b3c57bb27342faaaa07bd80d8ed5c9"}}, "title": "The use of positive end expiratory pressure in patients affected by COVID-19: Time to reconsider the relation between morphology and physiology.", "authors": [{"family": "Perchiazzi", "given": "Gaetano", "initials": "G", "orcid": "0000-0001-6834-6399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ef9ffc76bfe47c5afff104e9aaef020.json"}}, {"family": "Pellegrini", "given": "Mariangela", "initials": "M"}, {"family": "Chiodaroli", "given": "Elena", "initials": "E"}, {"family": "Urits", "given": "Ivan", "initials": "I"}, {"family": "Kaye", "given": "Alan D", "initials": "AD"}, {"family": "Viswanath", "given": "Omar", "initials": "O"}, {"family": "Varrassi", "given": "Giustino", "initials": "G"}, {"family": "Puntillo", "given": "Filomena", "initials": "F"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Best Pract Res Clin Anaesthesiol", "issn": "1878-1608", "volume": "34", "issue": "3", "pages": "561-567", "issn-l": "1753-3740"}, "abstract": "Coronavirus disease 2019 (COVID-19) is a new disease with different phases that can be catastrophic for subpopulations of patients with cardiovascular and pulmonary disease states at baseline. Appreciation for these different phases and treatment modalities, including manipulation of ventilatory settings and therapeutics, has made it a less lethal disease than when it emerged earlier this year. Different aspects of the disease are still largely unknown. However, laboratory investigation and clinical course of the COVID-19 show that this new disease is not a typical acute respiratory distress syndrome process, especially during the first phase. For this reason, the best strategy to be applied is to treat differently the single phases and to support the single functions of the failing organs as they appear.", "doi": "10.1016/j.bpa.2020.07.007", "pmid": "33004167", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7367781"}, {"db": "pii", "key": "S1521-6896(20)30062-8"}], "notes": [], "created": "2020-11-27T12:40:00.890Z", "modified": "2023-06-19T15:20:22.345Z"}, {"entity": "publication", "iuid": "2e1cf5a5227047e5988485212dca347c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e1cf5a5227047e5988485212dca347c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e1cf5a5227047e5988485212dca347c"}}, "title": "The Rheumatologist's Role in the Battle Against COVID-19: Insights from the Front Line and Challenges for the Future.", "authors": [{"family": "Koutsianas", "given": "Christos", "initials": "C"}, {"family": "Chatzidionysiou", "given": "Katerina", "initials": "K"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Mediterr J Rheumatol", "issn": "2529-198X", "volume": "31", "issue": "Suppl 2", "pages": "247-252", "issn-l": "2529-198X"}, "abstract": "As the worldwide burden of COVID-19 increases exponentially, healthcare systems are plagued by unprecedented pressure. In this setting, many rheumatologists across the globe have been recruited to support the front line, facing several unexpected challenges, but also providing valuable skills in combating COVID-19. At the same time, the rheumatic disease patient population may be especially vulnerable to such a rapidly contagious infectious disease and thus needs care and support that has to be provided quickly and efficiently. Clear advice on viral spread mitigation, precise guidelines on immunosuppressive treatment use and alternative methods of providing care, such as telemedicine, are a few of the rheumatologists' new challenges in caring for their patients in the COVID-19 era. Finally, among other specialties, rheumatologists hold a unique place in the fight against the hyper-inflammatory state caused by severe SARS-CoV-2 infection, leading to increased morbidity and mortality. Given their vast experience in the use of biologic and targeted therapies, rheumatologists should lead the way in developing reliable scientific evidence for the optimal treatment of severe COVID-19.", "doi": "10.31138/mjr.31.3.247", "pmid": "33196000", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "MJR-31-Suppl-2-247"}, {"db": "pmc", "key": "PMC7656125"}], "notes": [], "created": "2020-11-27T09:54:48.746Z", "modified": "2020-11-27T09:54:48.765Z"}, {"entity": "publication", "iuid": "7471dd74cf97437cb31db057a3d55c78", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7471dd74cf97437cb31db057a3d55c78.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7471dd74cf97437cb31db057a3d55c78"}}, "title": "The Covid-19 pandemic stress the need to build resilient production ecosystems", "authors": [{"family": "Gordon", "given": "Line J", "initials": "LJ"}], "type": "journal-article", "published": "2020-09-00", "journal": {"title": "Agric Human Values", "issn": "0889-048X", "volume": "37", "issue": "3", "pages": "645-646", "issn-l": null}, "abstract": null, "doi": "10.1007/s10460-020-10105-w", "pmid": "32836746", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10105"}, {"db": "pmc", "key": "PMC7245175"}], "notes": [], "created": "2020-12-07T11:32:08.285Z", "modified": "2021-12-06T13:18:20.606Z"}, {"entity": "publication", "iuid": "9ab6469f5a1445fba99bd72512ac0851", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ab6469f5a1445fba99bd72512ac0851.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ab6469f5a1445fba99bd72512ac0851"}}, "title": "The Association between Out-of-Pocket Expenditure and COVID-19 Mortality Globally.", "authors": [{"family": "El-Khatib", "given": "Ziad", "initials": "Z"}, {"family": "Otu", "given": "Akaninyene", "initials": "A"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}, {"family": "Yaya", "given": "Sanni", "initials": "S"}], "type": "letter", "published": "2020-09-00", "journal": {"title": "J Epidemiol Glob Health", "issn": "2210-6014", "issn-l": null, "volume": "10", "issue": "3", "pages": "192-193"}, "abstract": null, "doi": "10.2991/jegh.k.200725.001", "pmid": "32954706", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "j10/3/192"}, {"db": "pmc", "key": "PMC7509105"}], "notes": [], "created": "2020-12-03T09:27:59.119Z", "modified": "2021-02-26T08:47:00.100Z"}, {"entity": "publication", "iuid": "97292f4104f541cd96c0c9e68bbb847a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/97292f4104f541cd96c0c9e68bbb847a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/97292f4104f541cd96c0c9e68bbb847a"}}, "title": "The \"Vascular Surgery COVID-19 Collaborative\" (VASCC).", "authors": [{"family": "D'Oria", "given": "Mario", "initials": "M"}, {"family": "Mills", "given": "Joseph L", "initials": "JL"}, {"family": "Cohnert", "given": "Tina", "initials": "T"}, {"family": "Oderich", "given": "Gustavo S", "initials": "GS"}, {"family": "Hultgren", "given": "Rebecka", "initials": "R"}, {"family": "Lepidi", "given": "Sandro", "initials": "S"}, {"family": "Vascular Surgery COVID-19 Collaborative (VASCC)", "given": "", "initials": ""}], "type": "letter", "published": "2020-09-00", "journal": {"title": "Eur J Vasc Endovasc Surg", "issn": "1532-2165", "volume": "60", "issue": "3", "pages": "489-490", "issn-l": "1078-5884"}, "abstract": null, "doi": "10.1016/j.ejvs.2020.07.072", "pmid": "32798205", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1078-5884(20)30683-3"}, {"db": "pmc", "key": "PMC7388790"}], "notes": [], "created": "2020-12-07T13:22:26.320Z", "modified": "2020-12-07T13:22:26.330Z"}, {"entity": "publication", "iuid": "c76f6a1bc4f249ad8b183996150078a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c76f6a1bc4f249ad8b183996150078a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c76f6a1bc4f249ad8b183996150078a0"}}, "title": "Targeting TMPRSS2 in SARS-CoV-2 Infection.", "authors": [{"family": "Baughn", "given": "Linda B", "initials": "LB"}, {"family": "Sharma", "given": "Neeraj", "initials": "N"}, {"family": "Elhaik", "given": "Eran", "initials": "E"}, {"family": "Sekulic", "given": "Aleksandar", "initials": "A"}, {"family": "Bryce", "given": "Alan H", "initials": "AH"}, {"family": "Fonseca", "given": "Rafael", "initials": "R"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Mayo Clin Proc", "issn": "1942-5546", "volume": "95", "issue": "9", "pages": "1989-1999", "issn-l": "0025-6196"}, "abstract": "Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has rapidly caused a global pandemic associated with a novel respiratory infection: coronavirus disease-19 (COVID-19). Angiotensin-converting enzyme-2 (ACE2) is necessary to facilitate SARS-CoV-2 infection, but-owing to its essential metabolic roles-it may be difficult to target it in therapies. Transmembrane protease serine 2 (TMPRSS2), which interacts with ACE2, may be a better candidate for targeted therapies. Using publicly available expression data, we show that both ACE2 and TMPRSS2 are expressed in many host tissues, including lung. The highest expression of ACE2 is found in the testes, whereas the prostate displays the highest expression of TMPRSS2. Given the increased severity of disease among older men with SARS-CoV-2 infection, we address the potential roles of ACE2 and TMPRSS2 in their contribution to the sex differences in severity of disease. We show that expression levels of ACE2 and TMPRSS2 are overall comparable between men and women in multiple tissues, suggesting that differences in the expression levels of TMPRSS2 and ACE2 in the lung and other non-sex-specific tissues may not explain the gender disparities in severity of SARS CoV-2. However, given their instrumental roles for SARS-CoV-2 infection and their pleiotropic expression, targeting the activity and expression levels of TMPRSS2 is a rational approach to treat COVID-19.", "doi": "10.1016/j.mayocp.2020.06.018", "pmid": "32861340", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S0025-6196(20)30626-1"}, {"db": "pmc", "key": "PMC7368885"}], "notes": [], "created": "2020-12-07T10:20:25.960Z", "modified": "2021-02-26T08:45:03.245Z"}, {"entity": "publication", "iuid": "ff7fb22175a8472799663bb90467ac15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff7fb22175a8472799663bb90467ac15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff7fb22175a8472799663bb90467ac15"}}, "title": "Prioritizing Cleft/Craniofacial Surgical Care after the COVID-19 Pandemic.", "authors": [{"family": "Breugem", "given": "Corstiaan", "initials": "C"}, {"family": "Smit", "given": "Hans", "initials": "H"}, {"family": "Mark", "given": "Hans", "initials": "H"}, {"family": "Davies", "given": "Gareth", "initials": "G"}, {"family": "Schachner", "given": "Peter", "initials": "P"}, {"family": "Collard", "given": "Mechelle", "initials": "M"}, {"family": "Sell", "given": "Debbie", "initials": "D"}, {"family": "Autelitano", "given": "Luca", "initials": "L"}, {"family": "Rezzonico", "given": "Angela", "initials": "A"}, {"family": "Mazzoleni", "given": "Fabio", "initials": "F"}, {"family": "Novelli", "given": "Giorgio", "initials": "G"}, {"family": "Mossey", "given": "Peter", "initials": "P"}, {"family": "Persson", "given": "Martin", "initials": "M"}, {"family": "Mehendale", "given": "Felicity", "initials": "F"}, {"family": "Gaggl", "given": "Alexander", "initials": "A"}, {"family": "van Gogh", "given": "Christine", "initials": "C"}, {"family": "Zuurbier", "given": "Petra", "initials": "P"}, {"family": "Reinart", "given": "Siegmar", "initials": "S"}, {"family": "de Graaff", "given": "Feike", "initials": "F"}, {"family": "Meazzini", "given": "Costanza", "initials": "C"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Plast Reconstr Surg Glob Open", "issn": "2169-7574", "volume": "8", "issue": "9", "pages": "e3080", "issn-l": null}, "abstract": "It is anticipated that in due course the burden of emergency care due to COVID-19 infected patients will reduce sufficiently to permit elective surgical procedures to recommence. Prioritizing cleft/craniofacial surgery in the already overloaded medical system will then become an issue. The European Cleft Palate Craniofacial Association, together with the European Cleft and Craniofacial Initiative for Equality in Care, performed a brief survey to capture a current snapshot during a rapidly evolving pandemic.\n\nA questionnaire was sent to the 2242 participants who attended 1 of 3 recent international cleft/craniofacial meetings.\n\nThe respondents indicated that children with Robin sequence who were not responding to nonsurgical options should be treated as emergency cases. Over 70% of the respondents indicated that palate repair should be performed before the age of 15 months, an additional 22% stating the same be performed by 18 months. Placement of middle ear tubes, primary cleft lip surgery, alveolar bone grafting, and velopharyngeal insufficiency surgery also need prioritization. Children with craniofacial conditions such as craniosynostosis and increased intracranial pressure need immediate care, whilst children with craniosynostosis and associated obstructive sleep apnea syndrome or proptosis need surgical care within 3 months of the typical timing. Craniosynostosis without signs of increased intracranial pressure needs correction before the age of 18 months.\n\nThis survey indicates several areas of cleft and craniofacial conditions that need prioritization, but also certain areas where intervention is less urgent. We acknowledge that there will be differences in the post COVID-19 response according to circumstances and policies in individual countries.", "doi": "10.1097/GOX.0000000000003080", "pmid": "33133937", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7544383"}], "notes": [], "created": "2020-12-01T15:01:18.453Z", "modified": "2021-02-26T08:45:48.934Z"}, {"entity": "publication", "iuid": "679be0bb5b0c492f8c69165fadf5dfb2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/679be0bb5b0c492f8c69165fadf5dfb2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/679be0bb5b0c492f8c69165fadf5dfb2"}}, "title": "Predicted COVID-19 fatality rates based on age, sex, comorbidities and health system capacity.", "authors": [{"family": "Ghisolfi", "given": "Selene", "initials": "S"}, {"family": "Alm\u00e5s", "given": "Ingvild", "initials": "I"}, {"family": "Sandefur", "given": "Justin C", "initials": "JC"}, {"family": "von Carnap", "given": "Tillman", "initials": "T"}, {"family": "Heitner", "given": "Jesse", "initials": "J"}, {"family": "Bold", "given": "Tessa", "initials": "T"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "5", "issue": "9", "issn-l": "2059-7908"}, "abstract": "Early reports suggest the fatality rate from COVID-19 varies greatly across countries, but non-random testing and incomplete vital registration systems render it impossible to directly estimate the infection fatality rate (IFR) in many low- and middle-income countries. To fill this gap, we estimate the adjustments required to extrapolate estimates of the IFR from high-income to lower-income regions. Accounting for differences in the distribution of age, sex and relevant comorbidities yields substantial differences in the predicted IFR across 21 world regions, ranging from 0.11% in Western Sub-Saharan Africa to 1.07% for high-income Asia Pacific. However, these predictions must be treated as lower bounds in low- and middle-income countries as they are grounded in fatality rates from countries with advanced health systems. To adjust for health system capacity, we incorporate regional differences in the relative odds of infection fatality from childhood respiratory syncytial virus. This adjustment greatly diminishes but does not entirely erase the demography-based advantage predicted in the lowest income settings, with regional estimates of the predicted COVID-19 IFR ranging from 0.37% in Western Sub-Saharan Africa to 1.45% for Eastern Europe.", "doi": "10.1136/bmjgh-2020-003094", "pmid": "32912856", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-003094"}, {"db": "pmc", "key": "PMC7482102"}], "notes": [], "created": "2020-11-27T12:43:18.757Z", "modified": "2020-11-27T12:43:18.768Z"}, {"entity": "publication", "iuid": "0210f1afaeb74e4d9082a7d9ba9f8162", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0210f1afaeb74e4d9082a7d9ba9f8162.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0210f1afaeb74e4d9082a7d9ba9f8162"}}, "title": "Population-level COVID-19 mortality risk for non-elderly individuals overall and for non-elderly individuals without underlying diseases in pandemic epicenters.", "authors": [{"family": "Ioannidis", "given": "John P A", "initials": "JPA"}, {"family": "Axfors", "given": "Cathrine", "initials": "C"}, {"family": "Contopoulos-Ioannidis", "given": "Despina G", "initials": "DG"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Environ Res", "issn": "1096-0953", "issn-l": "0013-9351", "volume": "188", "issue": null, "pages": "109890"}, "abstract": "To provide estimates of the relative rate of COVID-19 death in people <65 years old versus older individuals in the general population, the absolute risk of COVID-19 death at the population level during the first epidemic wave, and the proportion of COVID-19 deaths in non-elderly people without underlying diseases in epicenters of the pandemic.\r\n\r\nCross-sectional survey of countries and US states with at least 800 COVID-19 deaths as of April 24, 2020 and with information on the number of deaths in people with age <65. Data were available for 14 countries (Belgium, Canada, France, Germany, India, Ireland, Italy, Mexico, Netherlands, Portugal, Spain, Sweden, Switzerland, UK) and 13 US states (California, Connecticut, Florida, Georgia, Illinois, Indiana, Louisiana, Maryland, Massachusetts, Michigan, New Jersey, New York, Pennsylvania). We also examined available data on COVID-19 deaths in people with age <65 and no underlying diseases.\r\n\r\nProportion of COVID-19 deaths in people <65 years old; relative mortality rate of COVID-19 death in people <65 versus \u226565 years old; absolute risk of COVID-19 death in people <65 and in those \u226580 years old in the general population as of June 17, 2020; absolute COVID-19 mortality rate expressed as equivalent of mortality rate from driving a motor vehicle.\r\n\r\nIndividuals with age <65 account for 4.5-11.2% of all COVID-19 deaths in European countries and Canada, 8.3-22.7% in the US locations, and were the majority in India and Mexico. People <65 years old had 30- to 100-fold lower risk of COVID-19 death than those \u226565 years old in 11 European countries and Canada, 16- to 52-fold lower risk in US locations, and less than 10-fold in India and Mexico. The absolute risk of COVID-19 death as of June 17, 2020 for people <65 years old in high-income countries ranged from 10 (Germany) to 349 per million (New Jersey) and it was 5 per million in India and 96 per million in Mexico. The absolute risk of COVID-19 death for people \u226580 years old ranged from 0.6 (Florida) to 17.5 per thousand (Connecticut). The COVID-19 mortality rate in people <65 years old during the period of fatalities from the epidemic was equivalent to the mortality rate from driving between 4 and 82 miles per day for 13 countries and 5 states, and was higher (equivalent to the mortality rate from driving 106-483 miles per day) for 8 other states and the UK. People <65 years old without underlying predisposing conditions accounted for only 0.7-3.6% of all COVID-19 deaths in France, Italy, Netherlands, Sweden, Georgia, and New York City and 17.7% in Mexico.\r\n\r\nPeople <65 years old have very small risks of COVID-19 death even in pandemic epicenters and deaths for people <65 years without underlying predisposing conditions are remarkably uncommon. Strategies focusing specifically on protecting high-risk elderly individuals should be considered in managing the pandemic.", "doi": "10.1016/j.envres.2020.109890", "pmid": "32846654", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0013-9351(20)30785-4"}, {"db": "pmc", "key": "PMC7327471"}, {"db": "URL", "key": "https://ars.els-cdn.com/content/image/1-s2.0-S0013935120307854-mmc2.pdf", "description": "Number of COVID-19 deaths contributed by specific age group and population characteristics for 14 countries and 13 US states"}], "notes": [], "created": "2020-11-22T09:56:51.290Z", "modified": "2021-02-26T08:46:59.789Z"}, {"entity": "publication", "iuid": "536b4d0da2254331a79a3bf4d5693abc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/536b4d0da2254331a79a3bf4d5693abc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/536b4d0da2254331a79a3bf4d5693abc"}}, "title": "Per capita death and infection rates should be avoided in international comparisons.", "authors": [{"family": "Silva", "given": "W T A F", "initials": "WTAF"}], "type": "letter", "published": "2020-09-00", "journal": {"title": "Public Health", "issn": "1476-5616", "volume": "186", "issue": null, "pages": "18-19", "issn-l": null}, "abstract": null, "doi": "10.1016/j.puhe.2020.06.038", "pmid": "32750504", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0033-3506(20)30276-6"}, {"db": "pmc", "key": "PMC7395585"}], "notes": [], "created": "2020-12-07T15:48:12.388Z", "modified": "2020-12-07T15:48:12.410Z"}, {"entity": "publication", "iuid": "c1f02d70a3814642add901ea579ed297", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1f02d70a3814642add901ea579ed297.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1f02d70a3814642add901ea579ed297"}}, "title": "Peer Review Week 2020: Eurosurveillance thanks all COVID-19 reviewers for their amazing work.", "authors": [{"family": "Eurosurveillance editorial team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "38", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.38.2009242", "pmid": "32975183", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7533617"}], "notes": [], "created": "2020-12-03T14:32:25.284Z", "modified": "2020-12-03T14:32:25.294Z"}, {"entity": "publication", "iuid": "5a93a8b03dbb42fba1d041a2c4b25fcc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5a93a8b03dbb42fba1d041a2c4b25fcc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5a93a8b03dbb42fba1d041a2c4b25fcc"}}, "title": "Management of the emergency response to the SARS-CoV-2 (COVID-19) outbreak in Stockholm, Sweden, and winter preparations.", "authors": [{"family": "Ohrling", "given": "Mikael", "initials": "M"}, {"family": "\u00d8vretveit", "given": "John", "initials": "J"}, {"family": "Lockowandt", "given": "Ulf", "initials": "U"}, {"family": "Brommels", "given": "Mats", "initials": "M"}, {"family": "Sparring", "given": "Vibeke", "initials": "V"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "J Prim Health Care", "issn": "1172-6156", "volume": "12", "issue": "3", "pages": "207-214", "issn-l": null}, "abstract": "INTRODUCTION Sweden is unique in adopting a 'no-lockdown' public health approach to the SARS-CoV-2 (COVID-19) outbreak. There were fears that health services would not be able to care for high numbers of COVID-19 patients. AIM To describe and review the emergency response of a public primary and community health-care organisation in Stockholm, Sweden, to the demand for care for COVID-19 and non-COVID-19 patients during March-July 2020, and summarise preparations for the months to follow. METHODS This was a rapid implementation action research case study, which also draws on one author's experience as Chief Executive Officer and other members' experience in an emergency management group. RESULTS Sweden experienced similar mortality per million population to the UK, despite the different public health strategy used to address the COVID-19 outbreak. The Stockholm-integrated public primary and community health-care service, serving a population of 2.3 million, made many changes quickly. One change included coordinating non-acute private health-care services, following the local government emergency directive to do so. DISCUSSION It is possible that the fast and effective response by management and services in primary and community health care reduced infection and hospital demand, which contributed to a lower mortality than otherwise expected. The actions and preparations described for Stockholm's response may provide ideas for other health-care systems. The partnership research approach between the Karolinska Medical University and the Region Stockholm health-care system used in this project shows that rapid research methods have advantages for both partners in an emergency situation.", "doi": "10.1071/HC20082", "pmid": "32988442", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "HC20082"}], "notes": [], "created": "2020-11-27T12:40:02.016Z", "modified": "2020-11-27T12:40:02.043Z"}, {"entity": "publication", "iuid": "f6a0171db3c84f31880fcd505070a25c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6a0171db3c84f31880fcd505070a25c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6a0171db3c84f31880fcd505070a25c"}}, "title": "Investigating mediated effects of fear of COVID-19 and COVID-19 misunderstanding in the association between problematic social media use, psychological distress, and insomnia.", "authors": [{"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Internet Interv", "issn": "2214-7829", "volume": "21", "issue": null, "pages": "100345", "issn-l": "2214-7829"}, "abstract": "Due to the serious situation of the novel coronavirus disease 2019 (COVID-19) worldwide, many countries have implemented policies to minimize the spread of COVID-19 infection. However, some of these policies prevent people from physical contact. Consequently, many individuals may rely on social media to obtain information concerning COVID-19. Unfortunately, social media use (especially problematic social media use) may give rise to psychological distress. Therefore, this study thus examined potential psychopathology to explain the association between problematic social media use, psychological distress, and insomnia.\n\nUtilizing an online survey, a sample of Iranian young adults (n = 1078 with 628 males; mean age = 26.24 years [SD \u00b1 7.41]) completed questions and psychometric scales concerning psychological distress, insomnia, problematic social media use, fear of COVID-19, and COVID-19 misunderstanding.\n\nProblematic social media use was significantly associated with psychological distress both directly and indirectly. The indirect effects were through fear of COVID-19 (unstandardized coefficient [B] = 0.177; Bootstrapping SE = 0.026) and COVID-19 misunderstanding (B = 0.060; Bootstrapping SE = 0.014). Problematic social media use was significantly associated with insomnia both directly and indirectly. The indirect effect was through fear of COVID-19 (B = 0.062; Bootstrapping SE = 0.019) but not COVID-19 misunderstanding (B = 0.012; Bootstrapping SE = 0.014).\n\nDue to the pressure of the COVID-19 outbreak, individuals are highly likely to develop psychological distress and insomnia. Apart from developing appropriate health policies to minimize the spread of COVID-19 infection, healthcare providers should design appropriate online campaigns to eliminate people's fear of COVID-19 and to diminish misunderstanding concerning COVID-19.", "doi": "10.1016/j.invent.2020.100345", "pmid": "32868992", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2214-7829(20)30111-1"}, {"db": "pii", "key": "100345"}, {"db": "pmc", "key": "PMC7449889"}], "notes": [], "created": "2020-12-07T07:49:52.173Z", "modified": "2021-02-26T08:45:48.868Z"}, {"entity": "publication", "iuid": "c4ef5f067c2a45bfba4aecc0e83e2ae4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c4ef5f067c2a45bfba4aecc0e83e2ae4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c4ef5f067c2a45bfba4aecc0e83e2ae4"}}, "title": "International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells: considerations for potential therapeutic agents to suppress coronavirus disease-19.", "authors": [{"family": "B\u00f6rger", "given": "Verena", "initials": "V"}, {"family": "Weiss", "given": "Daniel J", "initials": "DJ"}, {"family": "Anderson", "given": "Johnathon D", "initials": "JD"}, {"family": "Borr\u00e0s", "given": "Francesc E", "initials": "FE"}, {"family": "Bussolati", "given": "Benedetta", "initials": "B"}, {"family": "Carter", "given": "David R F", "initials": "DRF"}, {"family": "Dominici", "given": "Massimo", "initials": "M"}, {"family": "Falc\u00f3n-P\u00e9rez", "given": "Juan M", "initials": "JM"}, {"family": "Gimona", "given": "Mario", "initials": "M"}, {"family": "Hill", "given": "Andrew F", "initials": "AF"}, {"family": "Hoffman", "given": "Andrew M", "initials": "AM"}, {"family": "de Kleijn", "given": "Dominique", "initials": "D"}, {"family": "Levine", "given": "Bruce L", "initials": "BL"}, {"family": "Lim", "given": "Rebecca", "initials": "R"}, {"family": "L\u00f6tvall", "given": "Jan", "initials": "J"}, {"family": "Mitsialis", "given": "S Alex", "initials": "SA"}, {"family": "Mongui\u00f3-Tortajada", "given": "Marta", "initials": "M"}, {"family": "Muraca", "given": "Maurizio", "initials": "M"}, {"family": "Nieuwland", "given": "Rienk", "initials": "R"}, {"family": "Nowocin", "given": "Anna", "initials": "A"}, {"family": "O'Driscoll", "given": "Lorraine", "initials": "L"}, {"family": "Ortiz", "given": "Luis A", "initials": "LA"}, {"family": "Phinney", "given": "Donald G", "initials": "DG"}, {"family": "Reischl", "given": "Ilona", "initials": "I"}, {"family": "Rohde", "given": "Eva", "initials": "E"}, {"family": "Sanzenbacher", "given": "Ralf", "initials": "R"}, {"family": "Th\u00e9ry", "given": "Clotilde", "initials": "C"}, {"family": "Toh", "given": "Wei Seong", "initials": "WS"}, {"family": "Witwer", "given": "Kenneth W", "initials": "KW"}, {"family": "Lim", "given": "Sai Kiang", "initials": "SK"}, {"family": "Giebel", "given": "Bernd", "initials": "B"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Cytotherapy", "issn": "1477-2566", "issn-l": "1465-3249", "volume": "22", "issue": "9", "pages": "482-485"}, "abstract": "The International Society for Cellular and Gene Therapies (ISCT) and the International Society for Extracellular Vesicles (ISEV) recognize the potential of extracellular vesicles (EVs, including exosomes) from mesenchymal stromal cells (MSCs) and possibly other cell sources as treatments for COVID-19. Research and trials in this area are encouraged. However, ISEV and ISCT do not currently endorse the use of EVs or exosomes for any purpose in COVID-19, including but not limited to reducing cytokine storm, exerting regenerative effects or delivering drugs, pending the generation of appropriate manufacturing and quality control provisions, pre-clinical safety and efficacy data, rational clinical trial design and proper regulatory oversight.", "doi": "10.1016/j.jcyt.2020.05.002", "pmid": "32425691", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1465-3249(20)30662-9"}, {"db": "pmc", "key": "PMC7229942"}], "notes": [], "created": "2020-12-09T11:42:20.533Z", "modified": "2020-12-09T11:43:02.272Z"}, {"entity": "publication", "iuid": "f5b6380c3bbe4d49872fd22bd68b6c42", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f5b6380c3bbe4d49872fd22bd68b6c42.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f5b6380c3bbe4d49872fd22bd68b6c42"}}, "title": "Impact on hospital admission of ST-elevation myocardial infarction patients during coronavirus disease 2019 pandemic in an Italian Hospital.", "authors": [{"family": "Di Liberto", "given": "Ilenia Alessandra", "initials": "IA"}, {"family": "Pilato", "given": "Gerlando", "initials": "G"}, {"family": "Geraci", "given": "Salvatore", "initials": "S"}, {"family": "Milazzo", "given": "Diego", "initials": "D"}, {"family": "Vaccaro", "given": "Giovanni", "initials": "G"}, {"family": "Buccheri", "given": "Sergio", "initials": "S"}, {"family": "Caramanno", "given": "Giuseppe", "initials": "G"}], "type": "comparative study", "published": "2020-09-00", "journal": {"title": "J Cardiovasc Med (Hagerstown)", "issn": "1558-2035", "volume": "21", "issue": "9", "pages": "722-724", "issn-l": null}, "abstract": null, "doi": "10.2459/JCM.0000000000001053", "pmid": "32658006", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "01244665-202009000-00019"}], "notes": [], "created": "2020-12-08T14:13:31.185Z", "modified": "2022-11-10T06:47:26.083Z"}, {"entity": "publication", "iuid": "5bd4ea9f76bc4a0e9ebb682ab140f3c2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5bd4ea9f76bc4a0e9ebb682ab140f3c2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5bd4ea9f76bc4a0e9ebb682ab140f3c2"}}, "title": "Impact of COVID-19 on Pediatric Asthma: Practice Adjustments and Disease Burden.", "authors": [{"family": "Papadopoulos", "given": "Nikolaos G", "initials": "NG"}, {"family": "Custovic", "given": "Adnan", "initials": "A"}, {"family": "Deschildre", "given": "Antoine", "initials": "A"}, {"family": "Mathioudakis", "given": "Alexander G", "initials": "AG"}, {"family": "Phipatanakul", "given": "Wanda", "initials": "W"}, {"family": "Wong", "given": "Gary", "initials": "G"}, {"family": "Xepapadaki", "given": "Paraskevi", "initials": "P"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Bacharier", "given": "Leonard", "initials": "L"}, {"family": "Bonini", "given": "Matteo", "initials": "M"}, {"family": "Castro-Rodriguez", "given": "Jose A", "initials": "JA"}, {"family": "Chen", "given": "Zhimin", "initials": "Z"}, {"family": "Craig", "given": "Timothy", "initials": "T"}, {"family": "Ducharme", "given": "Francine M", "initials": "FM"}, {"family": "El-Sayed", "given": "Zeinab Awad", "initials": "ZA"}, {"family": "Feleszko", "given": "Wojciech", "initials": "W"}, {"family": "Fiocchi", "given": "Alessandro", "initials": "A"}, {"family": "Garcia-Marcos", "given": "Luis", "initials": "L"}, {"family": "Gern", "given": "James E", "initials": "JE"}, {"family": "Goh", "given": "Anne", "initials": "A"}, {"family": "G\u00f3mez", "given": "Ren\u00e9 Maximiliano", "initials": "RM"}, {"family": "Hamelmann", "given": "Eckard H", "initials": "EH"}, {"family": "Hedlin", "given": "Gunilla", "initials": "G"}, {"family": "Hossny", "given": "Elham M", "initials": "EM"}, {"family": "Jartti", "given": "Tuomas", "initials": "T"}, {"family": "Kalayci", "given": "Omer", "initials": "O"}, {"family": "Kaplan", "given": "Alan", "initials": "A"}, {"family": "Konradsen", "given": "Jon", "initials": "J"}, {"family": "Kuna", "given": "Piotr", "initials": "P"}, {"family": "Lau", "given": "Susanne", "initials": "S"}, {"family": "Le Souef", "given": "Peter", "initials": "P"}, {"family": "Lemanske", "given": "Robert F", "initials": "RF"}, {"family": "M\u00e4kel\u00e4", "given": "Mika J", "initials": "MJ"}, {"family": "Morais-Almeida", "given": "M\u00e1rio", "initials": "M"}, {"family": "Murray", "given": "Clare", "initials": "C"}, {"family": "Nagaraju", "given": "Karthik", "initials": "K"}, {"family": "Namazova-Baranova", "given": "Leyla", "initials": "L"}, {"family": "Garcia", "given": "Antonio Nieto", "initials": "AN"}, {"family": "Yusuf", "given": "Osman M", "initials": "OM"}, {"family": "Pitrez", "given": "Paulo M C", "initials": "PMC"}, {"family": "Pohunek", "given": "Petr", "initials": "P"}, {"family": "Pozo Beltr\u00e1n", "given": "Cesar Fireth", "initials": "CF"}, {"family": "Roberts", "given": "Graham C", "initials": "GC"}, {"family": "Valiulis", "given": "Arunas", "initials": "A"}, {"family": "Zar", "given": "Heather J", "initials": "HJ"}, {"family": "Pediatric Asthma in Real Life Collaborators", "given": "", "initials": ""}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "J Allergy Clin Immunol Pract", "issn": "2213-2201", "volume": "8", "issue": "8", "pages": "2592-2599.e3", "issn-l": null}, "abstract": "It is unclear whether asthma may affect susceptibility or severity of coronavirus disease 2019 (COVID-19) in children and how pediatric asthma services worldwide have responded to the pandemic.\n\nTo describe the impact of the COVID-19 pandemic on pediatric asthma services and on disease burden in their patients.\n\nAn online survey was sent to members of the Pediatric Asthma in Real Life think tank and the World Allergy Organization Pediatric Asthma Committee. It included questions on service provision, disease burden, and the clinical course of confirmed cases of COVID-19 infection among children with asthma.\n\nNinety-one respondents, caring for an estimated population of more than 133,000 children with asthma, completed the survey. COVID-19 significantly impacted pediatric asthma services: 39% ceased physical appointments, 47% stopped accepting new patients, and 75% limited patients' visits. Consultations were almost halved to a median of 20 (interquartile range, 10-25) patients per week. Virtual clinics and helplines were launched in most centers. Better than expected disease control was reported in 20% (10%-40%) of patients, whereas control was negatively affected in only 10% (7.5%-12.5%). Adherence also appeared to increase. Only 15 confirmed cases of COVID-19 were reported among the population; the estimated incidence is not apparently different from the reports of general pediatric cohorts.\n\nChildren with asthma do not appear to be disproportionately affected by COVID-19. Outcomes may even have improved, possibly through increased adherence and/or reduced exposures. Clinical services have rapidly responded to the pandemic by limiting and replacing physical appointments with virtual encounters.", "doi": "10.1016/j.jaip.2020.06.001", "pmid": "32561497", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-2198(20)30599-7"}, {"db": "pmc", "key": "PMC7297686"}], "notes": [], "created": "2020-12-09T07:42:32.450Z", "modified": "2021-02-26T08:46:13.142Z"}, {"entity": "publication", "iuid": "4bf14407a4204ed48d96d76ba237a0ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4bf14407a4204ed48d96d76ba237a0ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4bf14407a4204ed48d96d76ba237a0ca"}}, "title": "How can airborne transmission of COVID-19 indoors be minimised?", "authors": [{"family": "Morawska", "given": "Lidia", "initials": "L"}, {"family": "Tang", "given": "Julian W", "initials": "JW"}, {"family": "Bahnfleth", "given": "William", "initials": "W"}, {"family": "Bluyssen", "given": "Philomena M", "initials": "PM"}, {"family": "Boerstra", "given": "Atze", "initials": "A"}, {"family": "Buonanno", "given": "Giorgio", "initials": "G"}, {"family": "Cao", "given": "Junji", "initials": "J"}, {"family": "Dancer", "given": "Stephanie", "initials": "S"}, {"family": "Floto", "given": "Andres", "initials": "A"}, {"family": "Franchimon", "given": "Francesco", "initials": "F"}, {"family": "Haworth", "given": "Charles", "initials": "C"}, {"family": "Hogeling", "given": "Jaap", "initials": "J"}, {"family": "Isaxon", "given": "Christina", "initials": "C"}, {"family": "Jimenez", "given": "Jose L", "initials": "JL"}, {"family": "Kurnitski", "given": "Jarek", "initials": "J"}, {"family": "Li", "given": "Yuguo", "initials": "Y"}, {"family": "Loomans", "given": "Marcel", "initials": "M"}, {"family": "Marks", "given": "Guy", "initials": "G"}, {"family": "Marr", "given": "Linsey C", "initials": "LC"}, {"family": "Mazzarella", "given": "Livio", "initials": "L"}, {"family": "Melikov", "given": "Arsen Krikor", "initials": "AK"}, {"family": "Miller", "given": "Shelly", "initials": "S"}, {"family": "Milton", "given": "Donald K", "initials": "DK"}, {"family": "Nazaroff", "given": "William", "initials": "W"}, {"family": "Nielsen", "given": "Peter V", "initials": "PV"}, {"family": "Noakes", "given": "Catherine", "initials": "C"}, {"family": "Peccia", "given": "Jordan", "initials": "J"}, {"family": "Querol", "given": "Xavier", "initials": "X"}, {"family": "Sekhar", "given": "Chandra", "initials": "C"}, {"family": "Sepp\u00e4nen", "given": "Olli", "initials": "O"}, {"family": "Tanabe", "given": "Shin-Ichi", "initials": "SI"}, {"family": "Tellier", "given": "Raymond", "initials": "R"}, {"family": "Tham", "given": "Kwok Wai", "initials": "KW"}, {"family": "Wargocki", "given": "Pawel", "initials": "P"}, {"family": "Wierzbicka", "given": "Aneta", "initials": "A"}, {"family": "Yao", "given": "Maosheng", "initials": "M"}], "type": "letter", "published": "2020-09-00", "journal": {"title": "Environ Int", "issn": "1873-6750", "volume": "142", "issue": null, "pages": "105832", "issn-l": "0160-4120"}, "abstract": "During the rapid rise in COVID-19 illnesses and deaths globally, and notwithstanding recommended precautions, questions are voiced about routes of transmission for this pandemic disease. Inhaling small airborne droplets is probable as a third route of infection, in addition to more widely recognized transmission via larger respiratory droplets and direct contact with infected people or contaminated surfaces. While uncertainties remain regarding the relative contributions of the different transmission pathways, we argue that existing evidence is sufficiently strong to warrant engineering controls targeting airborne transmission as part of an overall strategy to limit infection risk indoors. Appropriate building engineering controls include sufficient and effective ventilation, possibly enhanced by particle filtration and air disinfection, avoiding air recirculation and avoiding overcrowding. Often, such measures can be easily implemented and without much cost, but if only they are recognised as significant in contributing to infection control goals. We believe that the use of engineering controls in public buildings, including hospitals, shops, offices, schools, kindergartens, libraries, restaurants, cruise ships, elevators, conference rooms or public transport, in parallel with effective application of other controls (including isolation and quarantine, social distancing and hand hygiene), would be an additional important measure globally to reduce the likelihood of transmission and thereby protect healthcare workers, patients and the general public.", "doi": "10.1016/j.envint.2020.105832", "pmid": "32521345", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0160-4120(20)31787-6"}, {"db": "pmc", "key": "PMC7250761"}], "notes": [], "created": "2020-12-09T10:12:52.339Z", "modified": "2020-12-09T10:12:52.349Z"}, {"entity": "publication", "iuid": "313df89a1c90406e9b8f582c33b51de2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/313df89a1c90406e9b8f582c33b51de2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/313df89a1c90406e9b8f582c33b51de2"}}, "title": "Heparin \u2013 An old drug with multiple potential targets in Covid\u201019 therapy", "authors": [{"family": "Lindahl", "given": "Ulf", "initials": "U"}, {"family": "Li", "given": "Jin\u2010Ping", "initials": "J"}], "type": "journal-article", "published": "2020-09-00", "journal": {"title": "J Thromb Haemost", "issn": "1538-7836", "issn-l": null, "volume": "18", "issue": "9", "pages": "2422-2424"}, "abstract": null, "doi": "10.1111/jth.14898", "pmid": "32426897", "labels": {"Type: Journal article": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC7276884"}], "notes": [], "created": "2020-12-04T08:52:17.388Z", "modified": "2021-12-06T13:16:11.752Z"}, {"entity": "publication", "iuid": "fc005ee705ce4020a7b935bd77738338", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc005ee705ce4020a7b935bd77738338.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc005ee705ce4020a7b935bd77738338"}}, "title": "Editorial: Fifty Campbell systematic reviews relevant to the policy response to COVID-19.", "authors": [{"family": "Board", "given": "Campbell Editorial", "initials": "CE"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Campbell Syst Rev", "issn": "1891-1803", "volume": "16", "issue": "3", "pages": "e1107", "issn-l": null}, "abstract": null, "doi": "10.1002/cl2.1107", "pmid": "34234882", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "CL21107"}, {"db": "pmc", "key": "PMC7435573"}], "notes": [], "created": "2021-08-06T08:24:53.424Z", "modified": "2021-08-06T08:25:44.337Z"}, {"entity": "publication", "iuid": "7df03080a93f4616927e9fdeb1a5576c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7df03080a93f4616927e9fdeb1a5576c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7df03080a93f4616927e9fdeb1a5576c"}}, "title": "Does prolonged propofol sedation of mechanically ventilated COVID-19 patients contribute to critical illness myopathy?", "authors": [{"family": "L\u00f6nnqvist", "given": "Per-Arne", "initials": "PA"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "Karlsson", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Wiklund", "given": "Lars", "initials": "L"}, {"family": "H\u00f6glund", "given": "Anna-Stina", "initials": "AS"}, {"family": "Larsson", "given": "Lars", "initials": "L"}], "type": "letter", "published": "2020-09-00", "journal": {"title": "Br J Anaesth", "issn": "1471-6771", "volume": "125", "issue": "3", "pages": "e334-e336", "issn-l": "0007-0912"}, "abstract": null, "doi": "10.1016/j.bja.2020.05.056", "pmid": "32600801", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0007-0912(20)30440-2"}, {"db": "pmc", "key": "PMC7284264"}], "notes": [], "created": "2020-11-22T08:45:29.899Z", "modified": "2021-02-26T08:45:48.396Z"}, {"entity": "publication", "iuid": "e973ffa8e5bb4fbeae8c51c1cf412a37", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e973ffa8e5bb4fbeae8c51c1cf412a37.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e973ffa8e5bb4fbeae8c51c1cf412a37"}}, "title": "Diagnostic performance of initial blood urea nitrogen combined with D-dimer levels for predicting in-hospital mortality in COVID-19 patients.", "authors": [{"family": "Cheng", "given": "Anying", "initials": "A"}, {"family": "Hu", "given": "Liu", "initials": "L"}, {"family": "Wang", "given": "Yiru", "initials": "Y"}, {"family": "Huang", "given": "Luyan", "initials": "L"}, {"family": "Zhao", "given": "Lingxi", "initials": "L"}, {"family": "Zhang", "given": "Congcong", "initials": "C"}, {"family": "Liu", "given": "Xiyue", "initials": "X"}, {"family": "Xu", "given": "Ranran", "initials": "R"}, {"family": "Liu", "given": "Feng", "initials": "F"}, {"family": "Li", "given": "Jinping", "initials": "J"}, {"family": "Ye", "given": "Dawei", "initials": "D"}, {"family": "Wang", "given": "Tao", "initials": "T"}, {"family": "Lv", "given": "Yongman", "initials": "Y"}, {"family": "Liu", "given": "Qingquan", "initials": "Q"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Int J Antimicrob Agents", "issn": "1872-7913", "volume": "56", "issue": "3", "pages": "106110", "issn-l": null}, "abstract": "The crude mortality rate in critical pneumonia cases with coronavirus disease 2019 (COVID-19) reaches 49%. This study aimed to test whether levels of blood urea nitrogen (BUN) in combination with D-dimer were predictors of in-hospital mortality in COVID-19 patients. The clinical characteristics of 305 COVID-19 patients were analysed and were compared between the survivor and non-survivor groups. Of the 305 patients, 85 (27.9%) died and 220 (72.1%) were discharged from hospital. Compared with discharged cases, non-survivor cases were older and their BUN and D-dimer levels were significantly higher (P < 0.0001). Least absolute shrinkage and selection operator (LASSO) and multivariable Cox regression analyses identified BUN and D-dimer levels as independent risk factors for poor prognosis. Kaplan-Meier analysis showed that elevated levels of BUN and D-dimer were associated with increased mortality (log-rank, P < 0.0001). The area under the curve for BUN combined with D-dimer was 0.94 (95% CI 0.90-0.97), with a sensitivity of 85% and specificity of 91%. Based on BUN and D-dimer levels on admission, a nomogram model was developed that showed good discrimination, with a concordance index of 0.94. Together, initial BUN and D-dimer levels were associated with mortality in COVID-19 patients. The combination of BUN \u2265 4.6 mmol/L and D-dimer \u2265 0.845 \u03bcg/mL appears to identify patients at high risk of in-hospital mortality, therefore it may prove to be a powerful risk assessment tool for severe COVID-19 patients.", "doi": "10.1016/j.ijantimicag.2020.106110", "pmid": "32712332", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0924-8579(20)30293-4"}, {"db": "pmc", "key": "PMC7377803"}], "notes": [], "created": "2020-12-07T16:15:03.755Z", "modified": "2021-02-26T08:45:48.829Z"}, {"entity": "publication", "iuid": "da6866a15f904121ace0557c7923f7b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/da6866a15f904121ace0557c7923f7b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/da6866a15f904121ace0557c7923f7b9"}}, "title": "Developing thinking around mental health science: the example of intrusive, emotional mental imagery after psychological trauma.", "authors": [{"family": "Singh", "given": "Laura", "initials": "L"}, {"family": "Espinosa", "given": "Lisa", "initials": "L"}, {"family": "Ji", "given": "Julie L", "initials": "JL"}, {"family": "Moulds", "given": "Michelle L", "initials": "ML"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Cogn Neuropsychiatry", "issn": "1464-0619", "volume": "25", "issue": "5", "pages": "348-363", "issn-l": "1354-6805"}, "abstract": "One route to advancing psychological treatments is to harness mental health science, a multidisciplinary approach including individuals with lived experience and end users (e.g., Holmes, E. A., Craske, M. G., & Graybiel, A. M. (2014). Psychological treatments: A call for mental-health science. Nature, 511(7509), 287-289. doi:10.1038/511287a). While early days, we here illustrate a line of research explored by our group-intrusive imagery-based memories after trauma.\n\nWe illustrate three possible approaches through which mental health science may stimulate thinking around psychological treatment innovation. First, focusing on single/specific target symptoms rather than full, multifaceted psychiatric diagnoses (e.g., intrusive trauma memories rather than all of posttraumatic stress disorder). Second, investigating mechanisms that can be modified in treatment (treatment mechanisms), rather than those which cannot (e.g., processes only linked to aetiology). Finally, exploring novel ways of delivering psychological treatment (peer-/self-administration), given the prevalence of mental health problems globally, and the corresponding need for effective interventions that can be delivered at scale and remotely for example at times of crisis (e.g., current COVID-19 pandemic).\n\nThese three approaches suggest options for potential innovative avenues through which mental health science may be harnessed to recouple basic and applied research and transform treatment development.", "doi": "10.1080/13546805.2020.1804845", "pmid": "32847486", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-22T09:55:45.251Z", "modified": "2020-11-30T08:36:36.440Z"}, {"entity": "publication", "iuid": "d9bdeca3f991438e9dec081348aa9da9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d9bdeca3f991438e9dec081348aa9da9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d9bdeca3f991438e9dec081348aa9da9"}}, "title": "Coagulation disorder in COVID-19.", "authors": [{"family": "Kander", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Lancet Haematol", "issn": "2352-3026", "volume": "7", "issue": "9", "pages": "e630-e632", "issn-l": null}, "abstract": null, "doi": "10.1016/S2352-3026(20)30218-0", "pmid": "32659213", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2352-3026(20)30218-0"}, {"db": "pmc", "key": "PMC7351400"}], "notes": [], "created": "2020-12-08T14:11:45.590Z", "modified": "2020-12-08T14:11:45.611Z"}, {"entity": "publication", "iuid": "c232619d7e704e339f0fd02748324289", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c232619d7e704e339f0fd02748324289.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c232619d7e704e339f0fd02748324289"}}, "title": "Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke: The Global COVID-19 Stroke Registry.", "authors": [{"family": "Ntaios", "given": "George", "initials": "G"}, {"family": "Michel", "given": "Patrik", "initials": "P"}, {"family": "Georgiopoulos", "given": "Georgios", "initials": "G"}, {"family": "Guo", "given": "Yutao", "initials": "Y"}, {"family": "Li", "given": "Wencheng", "initials": "W"}, {"family": "Xiong", "given": "Jing", "initials": "J"}, {"family": "Calleja", "given": "Patricia", "initials": "P"}, {"family": "Ostos", "given": "Fernando", "initials": "F"}, {"family": "Gonz\u00e1lez-Ortega", "given": "Guillermo", "initials": "G"}, {"family": "Fuentes", "given": "Blanca", "initials": "B"}, {"family": "Alonso de Leci\u00f1ana", "given": "Mar\u00eda", "initials": "M"}, {"family": "D\u00edez-Tejedor", "given": "Exuperio", "initials": "E"}, {"family": "Garc\u00eda-Madrona", "given": "Sebastian", "initials": "S"}, {"family": "Masjuan", "given": "Jaime", "initials": "J"}, {"family": "DeFelipe", "given": "Alicia", "initials": "A"}, {"family": "Turc", "given": "Guillaume", "initials": "G"}, {"family": "Gon\u00e7alves", "given": "Bruno", "initials": "B"}, {"family": "Domigo", "given": "Valerie", "initials": "V"}, {"family": "Dan", "given": "Gheorghe-Andrei", "initials": "GA"}, {"family": "Vezeteu", "given": "Roxana", "initials": "R"}, {"family": "Christensen", "given": "Hanne", "initials": "H"}, {"family": "Christensen", "given": "Louisa Marguerite", "initials": "LM"}, {"family": "Meden", "given": "Per", "initials": "P"}, {"family": "Hajdarevic", "given": "Lejla", "initials": "L"}, {"family": "Rodriguez-Lopez", "given": "Angela", "initials": "A"}, {"family": "D\u00edaz-Otero", "given": "Fernando", "initials": "F"}, {"family": "Garc\u00eda-Pastor", "given": "Andr\u00e9s", "initials": "A"}, {"family": "Gil-Nu\u00f1ez", "given": "Antonio", "initials": "A"}, {"family": "Maslias", "given": "Errikos", "initials": "E"}, {"family": "Strambo", "given": "Davide", "initials": "D"}, {"family": "Werring", "given": "David J", "initials": "DJ"}, {"family": "Chandratheva", "given": "Arvind", "initials": "A"}, {"family": "Benjamin", "given": "Laura", "initials": "L"}, {"family": "Simister", "given": "Robert", "initials": "R"}, {"family": "Perry", "given": "Richard", "initials": "R"}, {"family": "Beyrouti", "given": "Rahma", "initials": "R"}, {"family": "Jabbour", "given": "Pascal", "initials": "P"}, {"family": "Sweid", "given": "Ahmad", "initials": "A"}, {"family": "Tjoumakaris", "given": "Stavropoula", "initials": "S"}, {"family": "Cuadrado-Godia", "given": "Elisa", "initials": "E"}, {"family": "Campello", "given": "Ana Rodr\u00edguez", "initials": "AR"}, {"family": "Roquer", "given": "Jaume", "initials": "J"}, {"family": "Moreira", "given": "Tiago", "initials": "T"}, {"family": "Mazya", "given": "Michael V", "initials": "MV"}, {"family": "Bandini", "given": "Fabio", "initials": "F"}, {"family": "Matz", "given": "Karl", "initials": "K"}, {"family": "Iversen", "given": "Helle K", "initials": "HK"}, {"family": "Gonz\u00e1lez-Duarte", "given": "Alejandra", "initials": "A"}, {"family": "Tiu", "given": "Cristina", "initials": "C"}, {"family": "Ferrari", "given": "Julia", "initials": "J"}, {"family": "Vosko", "given": "Milan R", "initials": "MR"}, {"family": "Salzer", "given": "Helmut J F", "initials": "HJF"}, {"family": "Lamprecht", "given": "Bernd", "initials": "B"}, {"family": "D\u00fcnser", "given": "Martin W", "initials": "MW"}, {"family": "Cereda", "given": "Carlo W", "initials": "CW"}, {"family": "Quintero", "given": "\u00c1ngel Basilio Corredor", "initials": "\u00c1BC"}, {"family": "Korompoki", "given": "Eleni", "initials": "E"}, {"family": "Soriano-Navarro", "given": "Eduardo", "initials": "E"}, {"family": "Soto-Ram\u00edrez", "given": "Luis Enrique", "initials": "LE"}, {"family": "Casta\u00f1eda-M\u00e9ndez", "given": "Paulo F", "initials": "PF"}, {"family": "Bay-Sansores", "given": "Daniela", "initials": "D"}, {"family": "Arauz", "given": "Antonio", "initials": "A"}, {"family": "Cano-Nigenda", "given": "Vanessa", "initials": "V"}, {"family": "Kristoffersen", "given": "Espen Saxhaug", "initials": "ES"}, {"family": "Tiainen", "given": "Marjaana", "initials": "M"}, {"family": "Strbian", "given": "Daniel", "initials": "D"}, {"family": "Putaala", "given": "Jukka", "initials": "J"}, {"family": "Lip", "given": "Gregory Y H", "initials": "GYH"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Stroke", "issn": "1524-4628", "volume": "51", "issue": "9", "pages": "e254-e258", "issn-l": null}, "abstract": "Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that severe strokes are typically associated with poor prognosis and can be very efficiently treated with recanalization techniques, confirmation of this putative association is urgently warranted in a large representative patient cohort to alert stroke clinicians, and inform pre- and in-hospital acute stroke patient pathways. We pooled all consecutive patients hospitalized with laboratory-confirmed COVID-19 and acute ischemic stroke in 28 sites from 16 countries. To assess whether stroke severity and outcomes (assessed at discharge or at the latest assessment for those patients still hospitalized) in patients with acute ischemic stroke are different between patients with COVID-19 and non-COVID-19, we performed 1:1 propensity score matching analyses of our COVID-19 patients with non-COVID-19 patients registered in the Acute Stroke Registry and Analysis of Lausanne Registry between 2003 and 2019. Between January 27, 2020, and May 19, 2020, 174 patients (median age 71.2 years; 37.9% females) with COVID-19 and acute ischemic stroke were hospitalized (median of 12 patients per site). The median National Institutes of Health Stroke Scale was 10 (interquartile range [IQR], 4-18). In the 1:1 matched sample of 336 patients with COVID-19 and non-COVID-19, the median National Institutes of Health Stroke Scale was higher in patients with COVID-19 (10 [IQR, 4-18] versus 6 [IQR, 3-14]), P=0.03; (odds ratio, 1.69 [95% CI, 1.08-2.65] for higher National Institutes of Health Stroke Scale score). There were 48 (27.6%) deaths, of which 22 were attributed to COVID-19 and 26 to stroke. Among 96 survivors with available information about disability status, 49 (51%) had severe disability at discharge. In the propensity score-matched population (n=330), patients with COVID-19 had higher risk for severe disability (median mRS 4 [IQR, 2-6] versus 2 [IQR, 1-4], P<0.001) and death (odds ratio, 4.3 [95% CI, 2.22-8.30]) compared with patients without COVID-19. Our findings suggest that COVID-19 associated ischemic strokes are more severe with worse functional outcome and higher mortality than non-COVID-19 ischemic strokes.", "doi": "10.1161/STROKEAHA.120.031208", "pmid": "32787707", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7359900"}], "notes": [], "created": "2020-12-07T13:28:17.725Z", "modified": "2020-12-07T13:28:17.748Z"}, {"entity": "publication", "iuid": "cd3b5e14785c493a88046a386f265e86", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd3b5e14785c493a88046a386f265e86.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd3b5e14785c493a88046a386f265e86"}}, "title": "COVID-19: guidance on palliative care from a European Respiratory Society international task force.", "authors": [{"family": "Janssen", "given": "Daisy J A", "initials": "DJA"}, {"family": "Ekstr\u00f6m", "given": "Magnus", "initials": "M"}, {"family": "Currow", "given": "David C", "initials": "DC"}, {"family": "Johnson", "given": "Miriam J", "initials": "MJ"}, {"family": "Maddocks", "given": "Matthew", "initials": "M"}, {"family": "Simonds", "given": "Anita K", "initials": "AK"}, {"family": "Tonia", "given": "Thomy", "initials": "T"}, {"family": "Marsaa", "given": "Kristoffer", "initials": "K"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "volume": "56", "issue": "3", "issn-l": "0903-1936"}, "abstract": "Many people are dying from coronavirus disease 2019 (COVID-19), but consensus guidance on palliative care in COVID-19 is lacking. This new life-threatening disease has put healthcare systems under pressure, with the increased need of palliative care provided to many patients by clinicians who have limited prior experience in this field. Therefore, we aimed to make consensus recommendations for palliative care for patients with COVID-19 using the Convergence of Opinion on Recommendations and Evidence (CORE) process.\n\nWe invited 90 international experts to complete an online survey including stating their agreement, or not, with 14 potential recommendations. At least 70% agreement on directionality was needed to provide consensus recommendations. If consensus was not achieved on the first round, a second round was conducted.\n\n68 (75.6%) experts responded in the first round. Most participants were experts in palliative care, respiratory medicine or critical care medicine. In the first round, consensus was achieved on 13 recommendations based upon indirect evidence and clinical experience. In the second round, 58 (85.3%) out of 68 of the first-round experts responded, resulting in consensus for the 14th recommendation.\n\nThis multi-national task force provides consensus recommendations for palliative care for patients with COVID-19 concerning: advance care planning; (pharmacological) palliative treatment of breathlessness; clinician-patient communication; remote clinician-family communication; palliative care involvement in patients with serious COVID-19; spiritual care; psychosocial care; and bereavement care. Future studies are needed to generate empirical evidence for these recommendations.", "doi": "10.1183/13993003.02583-2020", "pmid": "32675211", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "13993003.02583-2020"}, {"db": "pmc", "key": "PMC7366176"}], "notes": [], "created": "2020-12-07T16:35:43.217Z", "modified": "2020-12-07T16:35:43.229Z"}, {"entity": "publication", "iuid": "b28bfa553b78495dabbac185e24c9ec3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b28bfa553b78495dabbac185e24c9ec3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b28bfa553b78495dabbac185e24c9ec3"}}, "title": "COVID-19 in people with multiple sclerosis: A global data sharing initiative.", "authors": [{"family": "Peeters", "given": "Liesbet M", "initials": "LM", "orcid": "0000-0002-6066-3899", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d3fd89e85e4e4368b68b086da3e8cae0.json"}}, {"family": "Parciak", "given": "Tina", "initials": "T"}, {"family": "Walton", "given": "Clare", "initials": "C"}, {"family": "Geys", "given": "Lotte", "initials": "L"}, {"family": "Moreau", "given": "Yves", "initials": "Y"}, {"family": "De Brouwer", "given": "Edward", "initials": "E"}, {"family": "Raimondi", "given": "Daniele", "initials": "D"}, {"family": "Pirmani", "given": "Ashkan", "initials": "A", "orcid": "0000-0003-4549-1002", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d72bbbd407ef4f5387e6653e68e127fc.json"}}, {"family": "Kalincik", "given": "Tomas", "initials": "T"}, {"family": "Edan", "given": "Gilles", "initials": "G"}, {"family": "Simpson-Yap", "given": "Steve", "initials": "S", "orcid": "0000-0001-6521-3056", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/845cbea3a2f64b9f880a43d6cc8cdb09.json"}}, {"family": "De Raedt", "given": "Luc", "initials": "L"}, {"family": "Dauxais", "given": "Yann", "initials": "Y"}, {"family": "Gautrais", "given": "Cl\u00e9ment", "initials": "C", "orcid": "0000-0001-8486-9616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac26ecdf30114e889dca0e02f3e1588d.json"}}, {"family": "Rodrigues", "given": "Paulo R", "initials": "PR"}, {"family": "McKenna", "given": "Landon", "initials": "L"}, {"family": "Lazovski", "given": "Nikola", "initials": "N"}, {"family": "Hillert", "given": "Jan", "initials": "J"}, {"family": "Forsberg", "given": "Lars", "initials": "L"}, {"family": "Spelman", "given": "Tim", "initials": "T", "orcid": "0000-0001-9204-3216", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab24deed7243491387cb220c2a0c8606.json"}}, {"family": "McBurney", "given": "Robert", "initials": "R"}, {"family": "Schmidt", "given": "Hollie", "initials": "H"}, {"family": "Bergmann", "given": "Arnfin", "initials": "A"}, {"family": "Braune", "given": "Stefan", "initials": "S"}, {"family": "Stahmann", "given": "Alexander", "initials": "A"}, {"family": "Middleton", "given": "Rodden", "initials": "R", "orcid": "0000-0002-2130-4420", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7adf9663f3ea4db7b2bfc70b724ad309.json"}}, {"family": "Salter", "given": "Amber", "initials": "A", "orcid": "0000-0002-1088-110X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e108ab0c847c4d5b8e66af7cfb6619ec.json"}}, {"family": "Bebo", "given": "Bruce F", "initials": "BF"}, {"family": "Rojas", "given": "Juan I", "initials": "JI"}, {"family": "van der Walt", "given": "Anneke", "initials": "A", "orcid": "0000-0002-4278-7003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4636e8ba06d94593929e1c30619cc500.json"}}, {"family": "Butzkueven", "given": "Helmut", "initials": "H"}, {"family": "van der Mei", "given": "Ingrid", "initials": "I"}, {"family": "Ivanov", "given": "Rumen", "initials": "R"}, {"family": "Hellwig", "given": "Kerstin", "initials": "K"}, {"family": "Sciascia do Olival", "given": "Guilherme", "initials": "G"}, {"family": "Cohen", "given": "Jeffrey A", "initials": "JA", "orcid": "0000-0001-9245-9772", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c2d691831eb430ea38710e0bec3ad61.json"}}, {"family": "Van Hecke", "given": "Wim", "initials": "W"}, {"family": "Dobson", "given": "Ruth", "initials": "R", "orcid": "0000-0002-2993-585X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b95a061e61124498ba6a11f27e0105dd.json"}}, {"family": "Magyari", "given": "Melinda", "initials": "M"}, {"family": "Brum", "given": "Doralina Guimar\u00e3es", "initials": "DG"}, {"family": "Alonso", "given": "Ricardo", "initials": "R"}, {"family": "Nicholas", "given": "Richard", "initials": "R"}, {"family": "Bauer", "given": "Johana", "initials": "J"}, {"family": "Chertcoff", "given": "Anibal", "initials": "A"}, {"family": "de S\u00e8ze", "given": "J\u00e9r\u00f4me", "initials": "J"}, {"family": "Louapre", "given": "C\u00e9line", "initials": "C"}, {"family": "Comi", "given": "Giancarlo", "initials": "G"}, {"family": "Rijke", "given": "Nick", "initials": "N"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Mult Scler", "issn": "1477-0970", "volume": "26", "issue": "10", "pages": "1157-1162", "issn-l": null}, "abstract": "We need high-quality data to assess the determinants for COVID-19 severity in people with MS (PwMS). Several studies have recently emerged but there is great benefit in aligning data collection efforts at a global scale.\n\nOur mission is to scale-up COVID-19 data collection efforts and provide the MS community with data-driven insights as soon as possible.\n\nNumerous stakeholders were brought together. Small dedicated interdisciplinary task forces were created to speed-up the formulation of the study design and work plan. First step was to agree upon a COVID-19 MS core data set. Second, we worked on providing a user-friendly and rapid pipeline to share COVID-19 data at a global scale.\n\nThe COVID-19 MS core data set was agreed within 48 hours. To date, 23 data collection partners are involved and the first data imports have been performed successfully. Data processing and analysis is an on-going process.\n\nWe reached a consensus on a core data set and established data sharing processes with multiple partners to address an urgent need for information to guide clinical practice. First results show that partners are motivated to share data to attain the ultimate joint goal: better understand the effect of COVID-19 in PwMS.", "doi": "10.1177/1352458520941485", "pmid": "32662757", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7361123"}], "notes": [], "created": "2020-12-08T10:43:30.100Z", "modified": "2023-06-19T14:42:04.913Z"}, {"entity": "publication", "iuid": "2d4895ba0d5e42d19aad6ebf4d7163d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d4895ba0d5e42d19aad6ebf4d7163d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d4895ba0d5e42d19aad6ebf4d7163d5"}}, "title": "Age, Inflammation, and Disease Location Are Critical Determinants of Intestinal Expression of SARS-CoV-2 Receptor ACE2 and TMPRSS2 in Inflammatory Bowel Disease.", "authors": [{"family": "Nowak", "given": "Jan Krzysztof", "initials": "JK"}, {"family": "Lindstr\u00f8m", "given": "Jonas Christoffer", "initials": "JC"}, {"family": "Kalla", "given": "Rahul", "initials": "R"}, {"family": "Ricanek", "given": "Petr", "initials": "P"}, {"family": "Halfvarson", "given": "Jonas", "initials": "J"}, {"family": "Satsangi", "given": "Jack", "initials": "J"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Gastroenterology", "issn": "1528-0012", "issn-l": null, "volume": "159", "issue": "3", "pages": "1151-1154.e2"}, "abstract": null, "doi": "10.1053/j.gastro.2020.05.030", "pmid": "32413354", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0016-5085(20)30653-3"}, {"db": "pmc", "key": "PMC7217073"}], "notes": [], "created": "2020-12-10T08:52:09.765Z", "modified": "2021-02-26T08:45:47.984Z"}, {"entity": "publication", "iuid": "b7ed4f4a0b3d4a3da337cd6166d65ef7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b7ed4f4a0b3d4a3da337cd6166d65ef7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b7ed4f4a0b3d4a3da337cd6166d65ef7"}}, "title": "A snapshot of European neurosurgery December 2019 vs. March 2020: just before and during the Covid-19 pandemic.", "authors": [{"family": "Mathiesen", "given": "T", "initials": "T"}, {"family": "Arraez", "given": "M", "initials": "M"}, {"family": "Asser", "given": "T", "initials": "T"}, {"family": "Balak", "given": "N", "initials": "N"}, {"family": "Barazi", "given": "S", "initials": "S"}, {"family": "Bernucci", "given": "C", "initials": "C"}, {"family": "Bolger", "given": "C", "initials": "C"}, {"family": "Broekman", "given": "M L D", "initials": "MLD"}, {"family": "Demetriades", "given": "A K", "initials": "AK"}, {"family": "Feldman", "given": "Z", "initials": "Z"}, {"family": "Fontanella", "given": "M M", "initials": "MM"}, {"family": "Foroglou", "given": "N", "initials": "N"}, {"family": "Lafuente", "given": "J", "initials": "J"}, {"family": "Maier", "given": "A D", "initials": "AD"}, {"family": "Meyer", "given": "B", "initials": "B"}, {"family": "Niemel\u00e4", "given": "M", "initials": "M"}, {"family": "Roche", "given": "P H", "initials": "PH"}, {"family": "Sala", "given": "F", "initials": "F"}, {"family": "Sampr\u00f3n", "given": "N", "initials": "N"}, {"family": "Sandvik", "given": "U", "initials": "U"}, {"family": "Schaller", "given": "K", "initials": "K"}, {"family": "Thome", "given": "C", "initials": "C"}, {"family": "Thys", "given": "M", "initials": "M"}, {"family": "Tisell", "given": "M", "initials": "M"}, {"family": "Vajkoczy", "given": "P", "initials": "P"}, {"family": "Visocchi", "given": "M", "initials": "M"}, {"family": "EANS Ethico-legal committee", "given": "", "initials": ""}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Acta Neurochir (Wien)", "issn": "0942-0940", "volume": "162", "issue": "9", "pages": "2221-2233", "issn-l": "0001-6268"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or Covid-19), which began as an epidemic in China and spread globally as a pandemic, has necessitated resource management to meet emergency needs of Covid-19 patients and other emergent cases. We have conducted a survey to analyze caseload and measures to adapt indications for a perception of crisis.\n\nWe constructed a questionnaire to survey a snapshot of neurosurgical activity, resources, and indications during 1 week with usual activity in December 2019 and 1 week during SARS-CoV-2 pandemic in March 2020. The questionnaire was sent to 34 neurosurgical departments in Europe; 25 departments returned responses within 5 days.\n\nWe found unexpectedly large differences in resources and indications already before the pandemic. Differences were also large in how much practice and resources changed during the pandemic. Neurosurgical beds and neuro-intensive care beds were significantly decreased from December 2019 to March 2020. The utilization of resources decreased via less demand for care of brain injuries and subarachnoid hemorrhage, postponing surgery and changed surgical indications as a method of rationing resources. Twenty departments (80%) reduced activity extensively, and the same proportion stated that they were no longer able to provide care according to legitimate medical needs.\n\nNeurosurgical centers responded swiftly and effectively to a sudden decrease of neurosurgical capacity due to relocation of resources to pandemic care. The pandemic led to rationing of neurosurgical care in 80% of responding centers. We saw a relation between resources before the pandemic and ability to uphold neurosurgical services. The observation of extensive differences of available beds provided an opportunity to show how resources that had been restricted already under normal conditions translated to rationing of care that may not be acceptable to the public of seemingly affluent European countries.", "doi": "10.1007/s00701-020-04482-8", "pmid": "32642834", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00701-020-04482-8"}, {"db": "pmc", "key": "PMC7343382"}], "notes": [], "created": "2020-12-08T14:30:29.037Z", "modified": "2020-12-08T14:30:29.046Z"}, {"entity": "publication", "iuid": "8e1aad5a6c4d4b588eb1de6f6cb85a2b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e1aad5a6c4d4b588eb1de6f6cb85a2b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e1aad5a6c4d4b588eb1de6f6cb85a2b"}}, "title": "A critical review of the pathophysiology of thrombotic complications and clinical practice recommendations for thromboprophylaxis in pregnant patients with COVID-19.", "authors": [{"family": "D'Souza", "given": "Rohan", "initials": "R"}, {"family": "Malham\u00e9", "given": "Isabelle", "initials": "I"}, {"family": "Teshler", "given": "Lizabeth", "initials": "L"}, {"family": "Acharya", "given": "Ganesh", "initials": "G"}, {"family": "Hunt", "given": "Beverley J", "initials": "BJ"}, {"family": "McLintock", "given": "Claire", "initials": "C"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "9", "pages": "1110-1120", "issn-l": "0001-6349"}, "abstract": "Those who are infected with Severe Acute Respiratory Syndrome-related CoronaVirus-2 are theoretically at increased risk of venous thromboembolism during self-isolation if they have reduced mobility or are dehydrated. Should patients develop coronavirus disease (COVID-19) pneumonia requiring hospital admission for treatment of hypoxia, the risk for thromboembolic complications increases greatly. These thromboembolic events are the result of at least two distinct mechanisms - microvascular thrombosis in the pulmonary system (immunothrombosis) and hospital-associated venous thromboembolism. Since pregnancy is a prothrombotic state, there is concern regarding the potentially increased risk of thrombotic complications among pregnant women with COVID-19. To date, however, pregnant women do not appear to have a substantially increased risk of thrombotic complications related to COVID-19. Nevertheless, several organizations have vigilantly issued pregnancy-specific guidelines for thromboprophylaxis in COVID-19. Discrepancies between these guidelines reflect the altruistic wish to protect patients and lack of high-quality evidence available to inform clinical practice. Low molecular weight heparin (LMWH) is the drug of choice for thromboprophylaxis in pregnant women with COVID-19. However, its utility in non-pregnant patients is only established against venous thromboembolism, as LMWH may have little or no effect on immunothrombosis. Decisions about initiation and duration of prophylactic anticoagulation in the context of pregnancy and COVID-19 must take into consideration disease severity, outpatient vs inpatient status, temporal relation between disease occurrence and timing of childbirth, and the underlying prothrombotic risk conferred by additional comorbidities. There is currently no evidence to recommend the use of intermediate or therapeutic doses of LMWH in thromboprophylaxis, which may increase bleeding risk without reducing thrombotic risk in pregnant patients with COVID-19. Likewise, there is no evidence to comment on the role of low-dose aspirin in thromboprophylaxis or of anti-cytokine and antiviral agents in preventing immunothrombosis. These unanswered questions are being studied within the context of clinical trials.", "doi": "10.1111/aogs.13962", "pmid": "32678949", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7404828"}], "notes": [], "created": "2020-11-26T12:14:06.219Z", "modified": "2020-11-30T08:45:13.568Z"}, {"entity": "publication", "iuid": "aeeb2de8be7c4b6dacb136d427561a49", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aeeb2de8be7c4b6dacb136d427561a49.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aeeb2de8be7c4b6dacb136d427561a49"}}, "title": "The SARS-CoV-2 N Protein Is a Good Component in a Vaccine.", "authors": [{"family": "Ahl\u00e9n", "given": "Gustaf", "initials": "G"}, {"family": "Frelin", "given": "Lars", "initials": "L"}, {"family": "Nikouyan", "given": "Negin", "initials": "N"}, {"family": "Weber", "given": "Friedemann", "initials": "F"}, {"family": "H\u00f6glund", "given": "Urban", "initials": "U"}, {"family": "Larsson", "given": "Olivia", "initials": "O"}, {"family": "Westman", "given": "Marie", "initials": "M"}, {"family": "Tuvesson", "given": "Ola", "initials": "O"}, {"family": "Gidlund", "given": "Eva-Karin", "initials": "EK"}, {"family": "Cadossi", "given": "Matteo", "initials": "M"}, {"family": "Appelberg", "given": "Sofia", "initials": "S"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "S\u00e4llberg", "given": "Matti", "initials": "M"}, {"family": "OPENCORONA Consortium", "given": "", "initials": ""}], "type": "letter", "published": "2020-08-31", "journal": {"title": "J Virol", "issn": "0022-538X", "volume": "94", "issue": "18", "issn-l": null}, "abstract": null, "doi": "10.1128/JVI.01279-20", "pmid": "32661140", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "JVI.01279-20"}, {"db": "pmc", "key": "PMC7459553"}], "notes": [], "created": "2020-11-19T19:35:23.241Z", "modified": "2020-12-08T10:44:08.917Z"}, {"entity": "publication", "iuid": "d813fde6181648e4abcc5ebc6d6c9cd6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d813fde6181648e4abcc5ebc6d6c9cd6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d813fde6181648e4abcc5ebc6d6c9cd6"}}, "title": "Screening for natural and derived bio-active compounds in preclinical and clinical studies: One of the frontlines of fighting the coronaviruses pandemic.", "authors": [{"family": "Khalifa", "given": "Shaden A M", "initials": "SAM"}, {"family": "Yosri", "given": "Nermeen", "initials": "N"}, {"family": "El-Mallah", "given": "Mohamed F", "initials": "MF"}, {"family": "Ghonaim", "given": "Reem", "initials": "R"}, {"family": "Guo", "given": "Zhiming", "initials": "Z"}, {"family": "Musharraf", "given": "Syed Ghulam", "initials": "SG"}, {"family": "Du", "given": "Ming", "initials": "M"}, {"family": "Khatib", "given": "Alfi", "initials": "A"}, {"family": "Xiao", "given": "Jianbo", "initials": "J"}, {"family": "Saeed", "given": "Aamer", "initials": "A"}, {"family": "El-Seedi", "given": "Haged H R", "initials": "HHR"}, {"family": "Zhao", "given": "Chao", "initials": "C"}, {"family": "Efferth", "given": "Thomas", "initials": "T"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}], "type": "journal article", "published": "2020-08-29", "journal": {"title": "Phytomedicine", "issn": "1618-095X", "volume": null, "issue": null, "pages": "153311", "issn-l": "0944-7113"}, "abstract": "Starting December 2019, mankind faced an unprecedented enemy, the COVID-19 virus. The world convened in international efforts, experiences and technologies in order to fight the emerging pandemic. Isolation, hygiene measure, diagnosis, and treatment are the most efficient ways of prevention and intervention nowadays. The health organizations and global care systems screened the available resources and offered recommendations of approved and proposed medications. However, the search for a specific selective therapy or vaccine against COVID-19 remains a challenge.\n\nA literature search was performed for the screening of natural and derived bio-active compounds which showed potent antiviral activity against coronaviruses using published articles, patents, clinical trials website (https://clinicaltrials.gov/) and web databases (PubMed, SCI Finder, Science Direct, and Google Scholar).\n\nThrough the screening for natural products with antiviral activities against different types of the human coronavirus, extracts of Lycoris radiata (L'H\u00e9r.), Gentiana scabra Bunge, Dioscorea batatas Decne., Cassia tora L., Taxillus chinensis (DC.), Cibotium barometz L. and Echinacea purpurea L. showed a promising effect against SARS-CoV. Out of the listed compound Lycorine, emetine dihydrochloride hydrate, pristimerin, harmine, conessine, berbamine, 4`-hydroxychalcone, papaverine, mycophenolic acid, mycophenolate mofetil, monensin sodium, cycloheximide, oligomycin and valinomycin show potent activity against human coronaviruses. Additionally, it is worth noting that some compounds have already moved into clinical trials for their activity against COVID-19 including fingolimod, methylprednisolone, chloroquine, tetrandrine and tocilizumab.\n\nNatural compounds and their derivatives could be used for developing potent therapeutics with significant activity against SARS-COV-2, providing a promising frontline in the fighting against COVID-19.", "doi": "10.1016/j.phymed.2020.153311", "pmid": "33067112", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0944-7113(20)30143-4"}, {"db": "pmc", "key": "PMC7455571"}], "notes": [], "created": "2020-11-26T12:33:13.706Z", "modified": "2020-11-27T11:51:36.346Z"}, {"entity": "publication", "iuid": "d1d9102f7bcc4023a72f702c84f034bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1d9102f7bcc4023a72f702c84f034bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1d9102f7bcc4023a72f702c84f034bd"}}, "title": "SARS-CoV-2 RNA in serum as predictor of severe outcome in COVID-19: a retrospective cohort study.", "authors": [{"family": "Hagman", "given": "Karl", "initials": "K"}, {"family": "Hedenstierna", "given": "Magnus", "initials": "M"}, {"family": "Gille-Johnson", "given": "Patrik", "initials": "P"}, {"family": "Hammas", "given": "Berit", "initials": "B"}, {"family": "Grabbe", "given": "Malin", "initials": "M"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Ursing", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2020-08-28", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "issn-l": "1058-4838", "volume": null, "issue": null, "pages": null}, "abstract": "Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes Coronavirus disease 2019 (COVID-19). This study aimed to determine if SARS-CoV-2 RNA in serum at admission correlated with clinical outcome in COVID-19.\r\n\r\nCOVID-19 patients admitted to the Infectious Diseases department of a tertiary level Swedish hospital, and sampled for SARS-CoV-2 RNA in serum at admission, April 10 to June 30 2020 were included in a cohort. Primary outcomes were day 28 all-cause mortality and progress to critical disease.\r\n\r\nThe cohort (N=167) consisted of 106 SARS-CoV-2 RNA serum negative and 61 positive patients. Median sampling time for initial SARS-CoV-2 in serum was 1 (IQR 1-2) day after admission corresponding to day 10 (IQR 8-12) after symptom onset. Median ages were 53 (IQR 44-67) and 63 (IQR 52-74) years for the PCR-negative and positive patients, respectively. In the serum PCR negative and positive groups 3/106 and 15/61 patients died, respectively.The hazard ratios for critical disease and all-cause mortality were 7.2 (95% CI 3.0-17) and 8.6 (95% CI 2.4-30), respectively for patients that were serum PCR positive compared to serum PCR negative.Conclusion: SARS-CoV-2 RNA in serum at hospital admission indicates a high-risk of progression to critical disease and death.", "doi": "10.1093/cid/ciaa1285", "pmid": "32856036", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "5898271"}, {"db": "pmc", "key": "PMC7499508"}], "notes": [], "created": "2020-12-04T08:59:08.585Z", "modified": "2021-02-26T08:45:48.744Z"}, {"entity": "publication", "iuid": "1edfbec48fb445bd9b215700435d8ded", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1edfbec48fb445bd9b215700435d8ded.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1edfbec48fb445bd9b215700435d8ded"}}, "title": "A case-report of widespread pulmonary embolism in a middle-aged male seven weeks after asymptomatic suspected COVID 19 infection.", "authors": [{"family": "Beckman", "given": "Mats", "initials": "M"}, {"family": "Nyr\u00e9n", "given": "Sven", "initials": "S"}, {"family": "Kistner", "given": "Anna", "initials": "A"}], "type": "case reports", "published": "2020-08-28", "journal": {"title": "Thromb J", "issn": "1477-9560", "volume": "18", "issue": null, "pages": "19", "issn-l": null}, "abstract": "Pulmonary embolism (PE) is seen in high frequency in hospital-treated patients with Covid-19. We present a case of suspected Covid-19 with long-term dyspnea and widespread PE.\n\nA 51- year old male, with no prior medical history, no medication, and non-smoker arrived at the emergency department with exercise induced dyspnea during 4-5 weeks and for the last 48 h dyspnea at rest. Seven weeks before hospitalization, he felt difficulties taking deep breaths for some days but no other symptoms. Oxygen saturation at rest was 93%. Troponin T was 1200 mg/L (ref < 15 mg/L). CT angiography revealed widespread bilateral segmental pulmonary embolism. Additional findings were ground glass opacities that could match Covid-19. The patient tested negative for SARS -CoV-2. Full dose tinzaparin was given for 2 days in hospital, followed by apixaban for 6 months. Recovery has been uneventful so far.\n\nLong-term breathing difficulties might be relatively common after non-hospitalized symptomatic Covid-19. The frequency of PE in this group is unknown. We report a case of suspected covid-19 with widespread PE and a long history of dyspnea but no other symptoms. In our case slight hypoxia and laboratory testing indicated significant disease, which was proven with contrast angiography. This case shows that PE is a differential diagnosis in non-hospitalized symptomatic Covid-19 with persisting breathing problems.", "doi": "10.1186/s12959-020-00235-w", "pmid": "32868974", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "235"}, {"db": "pmc", "key": "PMC7453687"}], "notes": [], "created": "2020-12-07T07:50:31.006Z", "modified": "2021-02-26T08:45:47.937Z"}, {"entity": "publication", "iuid": "69088da76ece4cee8ec3e363bdd5b05b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69088da76ece4cee8ec3e363bdd5b05b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69088da76ece4cee8ec3e363bdd5b05b"}}, "title": "Stressors, coping and symptoms of adjustment disorder in the course of the COVID-19 pandemic - study protocol of the European Society for Traumatic Stress Studies (ESTSS) pan-European study.", "authors": [{"family": "Lotzin", "given": "Annett", "initials": "A"}, {"family": "Acquarini", "given": "Elena", "initials": "E"}, {"family": "Ajdukovic", "given": "Dean", "initials": "D"}, {"family": "Ardino", "given": "Vittoria", "initials": "V"}, {"family": "B\u00f6ttche", "given": "Maria", "initials": "M"}, {"family": "Bondjers", "given": "Kristina", "initials": "K"}, {"family": "Bragesj\u00f6", "given": "Maria", "initials": "M"}, {"family": "Dragan", "given": "Ma\u0142gorzata", "initials": "M"}, {"family": "Grajewski", "given": "Piotr", "initials": "P"}, {"family": "Figueiredo-Braga", "given": "Margarida", "initials": "M"}, {"family": "Gelezelyte", "given": "Odeta", "initials": "O"}, {"family": "Javakhishvili", "given": "Jana Darejan", "initials": "JD"}, {"family": "Kazlauskas", "given": "Evaldas", "initials": "E"}, {"family": "Knefel", "given": "Matthias", "initials": "M"}, {"family": "Lueger-Schuster", "given": "Brigitte", "initials": "B"}, {"family": "Makhashvili", "given": "Nino", "initials": "N"}, {"family": "Mooren", "given": "Trudy", "initials": "T"}, {"family": "Sales", "given": "Luisa", "initials": "L"}, {"family": "Stevanovic", "given": "Aleksandra", "initials": "A"}, {"family": "Sch\u00e4fer", "given": "Ingo", "initials": "I"}], "type": "journal article", "published": "2020-08-27", "journal": {"title": "Eur J Psychotraumatol", "issn": "2000-8066", "issn-l": null, "volume": "11", "issue": "1", "pages": "1780832"}, "abstract": "During the current COVID-19 pandemic, the people in Europe are exposed to self-isolation, quarantine, job loss, risk of contracting COVID-19, or grief of loved ones. Such a complex array of stressors may lead to symptoms of adjustment disorder or posttraumatic stress disorder. This research protocol describes a study launched by the European Society of Traumatic Stress Studies (ESTSS) to investigate the impact of the COVID-19 pandemic on symptoms of adjustment disorder across European countries.\r\n\r\nThe longitudinal online cohort study aims (1) to explore psychosocial reactions to the COVID-19 pandemic across ten European countries; (2) to examine the relationships between risk and resilience factors, stressors and symptoms of adjustment disorder during the pandemic; and (3) to investigate whether these relationships are moderated by coping behaviours.\r\n\r\nIn ten countries (Austria, Croatia, Georgia, Germany, Italy, Lithuania, Netherlands, Poland, Portugal, and Sweden), between 1,000 and 2,000 participants will be recruited, depending on the size of the country. Participants will be assessed at two timepoints with a six-month interval. Following a conceptual framework based on the WHO's social framework of health, an assessment of risk and resilience factors, COVID-19 related stressors and pandemic-specific coping behaviours will be measured to estimate their contribution to symptoms of adjustment disorder. The Adjustment Disorder New Module 8 (ADNM-8) will be used to assess symptoms of adjustment disorder. As a secondary measure, symptoms of posttraumatic stress disorder will be measure using the Primary Care PTSD Screen for DSM-5 (PC-PTSD-5).\r\n\r\nThe relative contribution of risk factors, resilience factors, and stressors on symptoms of adjustment disorder or symptoms of posttraumatic stress disorder will be estimated using multilevel analysis. To determine the moderating effects of different types of coping behaviours on these relationships, a multilevel mediation analysis will be carried out.", "doi": "10.1080/20008198.2020.1780832", "pmid": "33029321", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "1780832"}, {"db": "pmc", "key": "PMC7473046"}], "notes": [], "created": "2020-12-01T17:33:46.838Z", "modified": "2022-11-10T06:53:25.923Z"}, {"entity": "publication", "iuid": "d8fc9caf2b854bb09e32120e40f11dbb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d8fc9caf2b854bb09e32120e40f11dbb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d8fc9caf2b854bb09e32120e40f11dbb"}}, "title": "Quality Assessment of the Chinese Clinical Trial Protocols Regarding Treatments for Coronavirus Disease 2019.", "authors": [{"family": "Zhang", "given": "Jiaxing", "initials": "J"}, {"family": "Lu", "given": "Yiling", "initials": "Y"}, {"family": "Kwong", "given": "Joey Sum-Wing", "initials": "JS"}, {"family": "Li", "given": "Xiaosi", "initials": "X"}, {"family": "Zheng", "given": "Wenyi", "initials": "W"}, {"family": "He", "given": "Rui", "initials": "R"}], "type": "systematic review", "published": "2020-08-27", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "11", "issue": null, "pages": "1330", "issn-l": "1663-9812"}, "abstract": "With the global spread of coronavirus disease 2019 (COVID-19), an increasing number of clinical trials are being designed and executed to evaluate the efficacy and safety of various therapies for COVID-19. We conducted this survey to assess the methodological quality of registry protocols on potential treatments for COVID-19.\n\nClinical trial protocols were identified on the ClinicalTrials.gov and the Chinese Clinical Trial Registry. Protocols were screened by two investigators independently against pre-defined eligibility criteria. Quality of the included protocols was assessed according to the modified 14-item SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2013 Statement.\n\nWe included 82 randomized controlled trial (RCT) protocols investigating treatment modalities for COVID-19. These ongoing trials are being conducted in 16 provinces, autonomous regions, and municipalities of China, and study interventions were either Western medicines (n = 56) or traditional Chinese medicine (n = 26). Findings of our quality assessment indicated that the existing trial protocols could be further improved on several aspects, including selection and definition of outcome measures, descriptions of study interventions and comparators, study subject recruitment time, definition of study inclusion and exclusion criteria, and allocation concealment methods. Descriptions of random sequence generation methodologies were accurate for the majority of included trial protocols (n = 64; 78.05%); however, reporting of allocation concealment remained unclear in 63 (76.83%) protocols. Therefore, the overall risk of selection bias across these RCTs was judged to be unclear. A total of 52 (63.41%) included RCT protocols were open-label trials and are thus associated with a high risk of performance bias and detection bias.\n\nQuality of currently available RCT protocols on the treatments for COVID-19 could be further improved. For transparency and effective knowledge translation in real-world clinically settings, it is important for trial investigators to standardize baseline treatments for patients with COVID-19 and assess clinically important core outcome measures. Despite eager anticipation from the public on the results of effectiveness trials in COVID-19, robust design, execution, and reporting of these trials should be regarded as high priority.", "doi": "10.3389/fphar.2020.01330", "pmid": "32973535", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7481475"}], "notes": [], "created": "2020-11-26T12:35:59.498Z", "modified": "2020-11-27T12:42:08.264Z"}, {"entity": "publication", "iuid": "5dede475e5044e6fbfba60106ec06167", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5dede475e5044e6fbfba60106ec06167.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5dede475e5044e6fbfba60106ec06167"}}, "title": "Four SARS-CoV-2 Genome Sequences from Late April in Stockholm, Sweden, Reveal a Rare Mutation in the Spike Protein", "authors": [{"family": "Soratto", "given": "Tatiany Aparecida Teixeira", "initials": "TAT"}, {"family": "Darban", "given": "Hamid", "initials": "H"}, {"family": "Bjerkner", "given": "Annelie", "initials": "A"}, {"family": "Coorens", "given": "Maarten", "initials": "M"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Allander", "given": "Tobias", "initials": "T"}, {"family": "Andersson", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal-article", "published": "2020-08-27", "journal": {"title": "Microbiol Resour Announc", "issn": "2576-098X", "volume": "9", "issue": "35", "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1128/mra.00934-20", "pmid": null, "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Health": null}, "xrefs": [{"db": "ENA", "key": "https://www.ebi.ac.uk/ena/browser/view/PRJEB39632", "description": "ENA PRJEB39632: SARS-CoV-2 genomes from late April in Stockholm, Sweden (reads and consensus sequences)"}], "notes": [], "created": "2021-01-20T12:57:49.990Z", "modified": "2021-11-18T08:48:14.869Z"}, {"entity": "publication", "iuid": "1b2f511e17b149f28b7964815215754a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b2f511e17b149f28b7964815215754a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b2f511e17b149f28b7964815215754a"}}, "title": "The Impact and Consequences of SARS-CoV-2 Pandemic on a Single University Dermatology Outpatient Clinic in Germany.", "authors": [{"family": "Wang", "given": "Rosi", "initials": "R"}, {"family": "Helf", "given": "Charlotte", "initials": "C"}, {"family": "Tizek", "given": "Linda", "initials": "L"}, {"family": "Neuhauser", "given": "Ruth", "initials": "R"}, {"family": "Eyerich", "given": "Kilian", "initials": "K"}, {"family": "Zink", "given": "Alexander", "initials": "A"}, {"family": "Eberlein", "given": "Bernadette", "initials": "B"}, {"family": "Biedermann", "given": "Tilo", "initials": "T"}, {"family": "Brockow", "given": "Knut", "initials": "K"}, {"family": "Boehner", "given": "Alexander", "initials": "A"}], "type": "journal article", "published": "2020-08-26", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "17", "pages": null}, "abstract": "The pandemic outbreak of coronavirus disease 2019 (COVID-19) affects health care systems globally and leads to other challenges besides infection and its direct medical consequences. The aim of this study was to investigate the impact of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic on the university dermatology outpatient clinic (UDOC) of the Technical University of Munich, Germany. We analyzed datasets from 2015 until 2020 extracted from the hospital information system database and our documented outpatient files regarding patient numbers, gender, age, and diagnoses. In 2020, case numbers of outpatient care declined significantly ( p = 0.021) compared to previous years and was related to the timing of political announcements answering SARS-CoV-2 pandemic. Additionally, during calendar week 10 to 15-the peak time of the spread of COVID-19 in Germany-the proportion of patients missing their consultation was significantly higher in 2020 than in 2019 (22.4% vs. 12.4%; p < 0.001). Gender-associated differences regarding absences were not detected, but patients aged 85 years or older were significantly more likely to miss their consultation compared to all other age groups (p = 0.002). Regarding different disease clusters, patients with chronic inflammatory skin diseases and infectious and malignant diseases were more likely to miss their consultation (p = 0.006). Noticeably, less patients with malignant diseases, and particularly malignant melanoma, were registered during this pandemic. Our data support the hypothesis that medically constructive prioritization might not be implemented properly by patients themselves. Identifying missed patients and catching up on their medical care apart from COVID-19 will pose an enormous challenge for health care systems globally.", "doi": "10.3390/ijerph17176182", "pmid": "32858870", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "ijerph17176182"}, {"db": "pmc", "key": "PMC7504311"}], "notes": [], "created": "2020-12-07T10:21:15.928Z", "modified": "2022-11-10T06:54:44.823Z"}, {"entity": "publication", "iuid": "412ce737cca4490db9b405d33efbdd05", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/412ce737cca4490db9b405d33efbdd05.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/412ce737cca4490db9b405d33efbdd05"}}, "title": "Psychological impact of COVID-19 in the Swedish population: Depression, anxiety, and insomnia and their associations to risk and vulnerability factors.", "authors": [{"family": "McCracken", "given": "Lance M", "initials": "LM"}, {"family": "Badinlou", "given": "Farzaneh", "initials": "F"}, {"family": "Buhrman", "given": "Monica", "initials": "M"}, {"family": "Brocki", "given": "Karin C", "initials": "KC"}], "type": "journal article", "published": "2020-08-26", "journal": {"title": "Eur Psychiatry", "issn": "1778-3585", "issn-l": "0924-9338", "volume": "63", "issue": "1", "pages": "e81"}, "abstract": "The 2019 coronavirus disease (COVID-19) pandemic, with its associated restrictions on daily life, is like a perfect storm for poor mental health and wellbeing. The purpose of this study was therefore to examine the impacts of COVID-19 on mental health and wellbeing during the ongoing pandemic in Sweden.\r\n\r\nStandardized measures of depression, anxiety, and insomnia as well as measures of risk and vulnerability factors known to be associated with poor mental health outcomes were administered through a national, online, cross-sectional survey (n = 1,212; mean age 36.1 years; 73% women).\r\n\r\nOur findings show significant levels of depression, anxiety, and insomnia in Sweden, at rates of 30%, 24.2%, and 38%, respectively. The strongest predictors of these outcomes included poor self-rated overall health and a history of mental health problems. The presence of COVID-19 symptoms and specific health and financial worries related to the pandemic also appeared important.\r\n\r\nThe impacts of COVID-19 on mental health in Sweden are comparable to impacts shown in previous studies in Italy and China. Importantly, the pandemic seems to impose most on the mental health of those already burdened with the impacts of mental health problems. These results provide a basis for providing more support for vulnerable groups, and for developing psychological interventions suited to the ongoing pandemic and for similar events in the future.", "doi": "10.1192/j.eurpsy.2020.81", "pmid": "32843115", "labels": {"Type: Journal article": null, "Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0924933820000814"}, {"db": "pmc", "key": "PMC7503043"}], "notes": [], "created": "2020-11-22T09:57:25.705Z", "modified": "2022-11-10T06:55:13.268Z"}, {"entity": "publication", "iuid": "15f244f3562b4f0fb95392207e8d9726", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15f244f3562b4f0fb95392207e8d9726.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15f244f3562b4f0fb95392207e8d9726"}}, "title": "Thinking strategically for COVID-19: suppress and lift, to flatten or to crush?", "authors": [{"family": "Khalife", "given": "Jade", "initials": "J"}], "type": "journal article", "published": "2020-08-25", "journal": {"title": "East Mediterr Health J", "issn": "1687-1634", "volume": "26", "issue": "8", "pages": "877-878", "issn-l": null}, "abstract": null, "doi": "10.26719/emhj.20.091", "pmid": "32896879", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-06T07:17:29.471Z", "modified": "2020-12-06T07:17:29.492Z"}, {"entity": "publication", "iuid": "47b726dd88e94d50acb444651310dee1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47b726dd88e94d50acb444651310dee1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47b726dd88e94d50acb444651310dee1"}}, "title": "Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19.", "authors": [{"family": "Rodriguez", "given": "Lucie", "initials": "L"}, {"family": "Pekkarinen", "given": "Pirkka T", "initials": "PT"}, {"family": "Lakshmikanth", "given": "Tadepally", "initials": "T"}, {"family": "Tan", "given": "Ziyang", "initials": "Z"}, {"family": "Consiglio", "given": "Camila Rosat", "initials": "CR"}, {"family": "Pou", "given": "Christian", "initials": "C"}, {"family": "Chen", "given": "Yang", "initials": "Y"}, {"family": "Mugabo", "given": "Constantin Habimana", "initials": "CH"}, {"family": "Nguyen", "given": "Ngoc Anh", "initials": "NA"}, {"family": "Nowlan", "given": "Kirsten", "initials": "K"}, {"family": "Strandin", "given": "Tomas", "initials": "T"}, {"family": "Levanov", "given": "Lev", "initials": "L"}, {"family": "Mikes", "given": "Jaromir", "initials": "J"}, {"family": "Wang", "given": "Jun", "initials": "J"}, {"family": "Kantele", "given": "Anu", "initials": "A"}, {"family": "Hepojoki", "given": "Jussi", "initials": "J"}, {"family": "Vapalahti", "given": "Olli", "initials": "O"}, {"family": "Heinonen", "given": "Santtu", "initials": "S"}, {"family": "Kek\u00e4l\u00e4inen", "given": "Eliisa", "initials": "E"}, {"family": "Brodin", "given": "Petter", "initials": "P"}], "type": "journal article", "published": "2020-08-25", "journal": {"title": "Cell Rep Med", "issn": "2666-3791", "issn-l": "2666-3791", "volume": "1", "issue": "5", "pages": "100078"}, "abstract": "Severe disease of SARS-CoV-2 is characterized by vigorous inflammatory responses in the lung, often with a sudden onset after 5-7 days of stable disease. Efforts to modulate this hyperinflammation and the associated acute respiratory distress syndrome rely on the unraveling of the immune cell interactions and cytokines that drive such responses. Given that every patient is captured at different stages of infection, longitudinal monitoring of the immune response is critical and systems-level analyses are required to capture cellular interactions. Here, we report on a systems-level blood immunomonitoring study of 37 adult patients diagnosed with COVID-19 and followed with up to 14 blood samples from acute to recovery phases of the disease. We describe an IFN\u03b3-eosinophil axis activated before lung hyperinflammation and changes in cell-cell co-regulation during different stages of the disease. We also map an immune trajectory during recovery that is shared among patients with severe COVID-19.", "doi": "10.1016/j.xcrm.2020.100078", "pmid": "32838342", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://ki.app.box.com/s/sby0jesyu23a65cbgv51vpbzqjdmipr1", "description": "Raw mass cytometry data and the Olink protein data"}, {"db": "URL", "key": "https://github.com/rodriluc/SARS-CoV2_study", "description": "Analysis code"}, {"db": "URL", "key": "https://www.cell.com/cms/10.1016/j.xcrm.2020.100078/attachment/53aca693-33e7-4b26-881f-ea11c7c15ad1/mmc1.pdf", "description": "IgG data"}], "notes": [], "created": "2020-10-28T09:10:41.202Z", "modified": "2021-02-26T08:45:48.110Z"}, {"entity": "publication", "iuid": "b07cf88cd3a84c39b27242bbb46c99b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b07cf88cd3a84c39b27242bbb46c99b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b07cf88cd3a84c39b27242bbb46c99b3"}}, "title": "Social distancing laws cause only small losses of economic activity during the COVID-19 pandemic in Scandinavia.", "authors": [{"family": "Sheridan", "given": "Adam", "initials": "A"}, {"family": "Andersen", "given": "Asger Lau", "initials": "AL"}, {"family": "Hansen", "given": "Emil Toft", "initials": "ET"}, {"family": "Johannesen", "given": "Niels", "initials": "N"}], "type": "journal article", "published": "2020-08-25", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "117", "issue": "34", "pages": "20468-20473", "issn-l": "0027-8424"}, "abstract": "This paper uses real-time transaction data from a large bank in Scandinavia to estimate the effect of social distancing laws on consumer spending in the coronavirus 2019 (COVID-19) pandemic. The analysis exploits a natural experiment to disentangle the effects of the virus and the laws aiming to contain it: Denmark and Sweden were similarly exposed to the pandemic but only Denmark imposed significant restrictions on social and economic activities. We estimate that aggregate spending dropped by around 25% (95% CI: 24 to 26%) in Sweden and, as a result of the shutdown, by 4 additional percentage points (95% CI: 3 to 5 percentage points [p.p.]) in Denmark. This suggests that most of the economic contraction is caused by the virus itself and occurs regardless of social distancing laws. The age gradient in the estimates suggests that social distancing reinforces the virus-induced drop in spending for low-health-risk individuals but attenuates it for high-risk individuals by lowering the overall prevalence of the virus in the society.", "doi": "10.1073/pnas.2010068117", "pmid": "32747573", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2010068117"}, {"db": "pmc", "key": "PMC7456178"}], "notes": [], "created": "2020-12-07T16:00:21.918Z", "modified": "2020-12-07T16:00:21.930Z"}, {"entity": "publication", "iuid": "1e96656d2f8b4ace83a45b4423931a25", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1e96656d2f8b4ace83a45b4423931a25.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1e96656d2f8b4ace83a45b4423931a25"}}, "title": "Interventions to suppress the coronavirus pandemic will increase unemployment and lead to many premature deaths.", "authors": [{"family": "Ros\u00e9n", "given": "M\u00e5ns", "initials": "M"}, {"family": "Stenbeck", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2020-08-25", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": null, "issue": null, "pages": "1403494820947974"}, "abstract": "Interventions to suppress the coronavirus pandemic have led to economic recession and higher unemployment, which will increase mortality and decrease quality of life. The aim of this article is to estimate the consequences on mortality and life expectancy of increased unemployment rates due to the coronavirus pandemic in Sweden and other countries.\r\n\r\nBased on recent increases and expected future unemployment rates due to the coronavirus pandemic, results from a systematic review and data from vital statistics in Sweden, the number of premature deaths due to unemployment in Sweden have been estimated.\r\n\r\nBased on our assumptions, the calculations show that if the number of unemployed persons in Sweden increases by 100,000, one may expect some 1800 more premature deaths during the following 9 years. If the duration of the recession is limited to 4 years, excess deaths due to unemployment may be around 800. On average, the unemployed will lose 2 years of their remaining life expectancy. In many other countries unemployment rates have or are estimated to rise more than in Sweden, sometimes two- or threefold, suggesting hundreds of thousands of excess deaths due to unemployment.\r\n\r\nInterventions to suppress the coronavirus pandemic include the shut-down of economic activities and lead to increased all-cause mortality. These public health effects must be considered in the decision-making process and should be added to overall estimates of the effects of the pandemic on public health.", "doi": "10.1177/1403494820947974", "pmid": "32842900", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2020-11-26T14:07:08.227Z", "modified": "2022-11-10T06:58:24.372Z"}, {"entity": "publication", "iuid": "99c39777a8b44be79113d736aaa9af74", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/99c39777a8b44be79113d736aaa9af74.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/99c39777a8b44be79113d736aaa9af74"}}, "title": "Immune responses during COVID-19 infection.", "authors": [{"family": "Melenotte", "given": "Cl\u00e9a", "initials": "C"}, {"family": "Silvin", "given": "Aymeric", "initials": "A"}, {"family": "Goubet", "given": "Anne-Ga\u00eblle", "initials": "AG"}, {"family": "Lahmar", "given": "Imran", "initials": "I"}, {"family": "Dubuisson", "given": "Agathe", "initials": "A"}, {"family": "Zumla", "given": "Alimuddin", "initials": "A"}, {"family": "Raoult", "given": "Didier", "initials": "D"}, {"family": "Merad", "given": "Mansouria", "initials": "M"}, {"family": "Gachot", "given": "Bertrand", "initials": "B"}, {"family": "H\u00e9non", "given": "Cl\u00e9mence", "initials": "C"}, {"family": "Solary", "given": "Eric", "initials": "E"}, {"family": "Fontenay", "given": "Michaela", "initials": "M"}, {"family": "Andr\u00e9", "given": "Fabrice", "initials": "F"}, {"family": "Maeurer", "given": "Markus", "initials": "M"}, {"family": "Ippolito", "given": "Giuseppe", "initials": "G"}, {"family": "Piacentini", "given": "Mauro", "initials": "M"}, {"family": "Wang", "given": "Fu-Sheng", "initials": "FS"}, {"family": "Ginhoux", "given": "Florent", "initials": "F"}, {"family": "Marabelle", "given": "Aur\u00e9lien", "initials": "A"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}, {"family": "Derosa", "given": "Lisa", "initials": "L"}, {"family": "Zitvogel", "given": "Laurence", "initials": "L"}], "type": "journal article", "published": "2020-08-25", "journal": {"title": "Oncoimmunology", "issn": "2162-4011", "volume": "9", "issue": "1", "pages": "1807836", "issn-l": null}, "abstract": "Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV (SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV) in 2012 and 2015, and SARS-CoV-2 in 2020, have been causing severe and fatal human epidemics. The unpredictability of coronavirus disease-19 (COVID-19) poses a major burden on health care and economic systems across the world. This is caused by the paucity of in-depth knowledge of the risk factors for severe COVID-19, insufficient diagnostic tools for the detection of SARS-CoV-2, as well as the absence of specific and effective drug treatments. While protective humoral and cellular immune responses are usually mounted against these betacoronaviruses, immune responses to SARS-CoV2 sometimes derail towards inflammatory tissue damage, leading to rapid admissions to intensive care units. The lack of knowledge on mechanisms that tilt the balance between these two opposite outcomes poses major threats to many ongoing clinical trials dealing with immunostimulatory or immunoregulatory therapeutics. This review will discuss innate and cognate immune responses underlying protective or deleterious immune reactions against these pathogenic coronaviruses.", "doi": "10.1080/2162402X.2020.1807836", "pmid": "32939324", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "1807836"}, {"db": "pmc", "key": "PMC7480812"}], "notes": [], "created": "2020-11-26T12:15:02.048Z", "modified": "2020-11-27T12:42:13.354Z"}, {"entity": "publication", "iuid": "fc8a52681ad84a3cb81c18e72172ee8b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc8a52681ad84a3cb81c18e72172ee8b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc8a52681ad84a3cb81c18e72172ee8b"}}, "title": "Has Sweden's controversial covid-19 strategy been successful or not?", "authors": [{"family": "Murray", "given": "John", "initials": "J"}], "type": "letter", "published": "2020-08-25", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "370", "issue": null, "pages": "m3255", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m3255", "pmid": "32843334", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-07T10:26:12.353Z", "modified": "2023-01-13T13:35:57.788Z"}, {"entity": "publication", "iuid": "9bdc4f367ba845b2be31cf156b1c4ebd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9bdc4f367ba845b2be31cf156b1c4ebd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9bdc4f367ba845b2be31cf156b1c4ebd"}}, "title": "An Ethics Framework for Making Resource Allocation Decisions Within Clinical Care: Responding to COVID-19.", "authors": [{"family": "Dawson", "given": "Angus", "initials": "A"}, {"family": "Isaacs", "given": "David", "initials": "D"}, {"family": "Jansen", "given": "Melanie", "initials": "M"}, {"family": "Jordens", "given": "Christopher", "initials": "C"}, {"family": "Kerridge", "given": "Ian", "initials": "I"}, {"family": "Kihlbom", "given": "Ulrik", "initials": "U"}, {"family": "Kilham", "given": "Henry", "initials": "H"}, {"family": "Preisz", "given": "Anne", "initials": "A"}, {"family": "Sheahan", "given": "Linda", "initials": "L"}, {"family": "Skowronski", "given": "George", "initials": "G"}], "type": "journal article", "published": "2020-08-25", "journal": {"title": "J Bioeth Inq", "issn": "1176-7529", "volume": null, "issue": null, "issn-l": null}, "abstract": "On March, 24, 2020, 818 cases of COVID-19 had been reported in New South Wales, Australia, and new cases were increasing at an exponential rate. In anticipation of resource constraints arising in clinical settings as a result of the COVID-19 pandemic, a working party of ten ethicists (seven clinicians and three full-time academics) was convened at the University of Sydney to draft an ethics framework to support resource allocation decisions. The framework guides decision-makers using a question-and-answer format, in language that avoids philosophical and medical technicality. The working party met five times over the following week and then submitted a draft Framework for consideration by two groups of intensivists and one group of academic ethicists. It was also presented to a panel on a national current affairs programme. The Framework was then revised on the basis of feedback from these sources and made publicly available online on April 3, ten days after the initial meeting. The framework is published here in full to stimulate ongoing discussion about rapid development of user-friendly clinical ethics resources in ongoing and future pandemics.", "doi": "10.1007/s11673-020-10007-w", "pmid": "32840833", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11673-020-10007-w"}, {"db": "pmc", "key": "PMC7445717"}], "notes": [], "created": "2020-12-07T10:28:14.151Z", "modified": "2020-12-07T10:28:14.173Z"}, {"entity": "publication", "iuid": "d4e822d3f5534290bc611a668851656b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4e822d3f5534290bc611a668851656b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4e822d3f5534290bc611a668851656b"}}, "title": "The burden of alcohol on health care during COVID-19.", "authors": [{"family": "Stockwell", "given": "Tim", "initials": "T"}, {"family": "Andreasson", "given": "Sven", "initials": "S"}, {"family": "Cherpitel", "given": "Cheryl", "initials": "C"}, {"family": "Chikritzhs", "given": "Tanya", "initials": "T"}, {"family": "Dangardt", "given": "Frida", "initials": "F"}, {"family": "Holder", "given": "Harold", "initials": "H"}, {"family": "Naimi", "given": "Timothy", "initials": "T"}, {"family": "Sherk", "given": "Adam", "initials": "A"}], "type": "journal article", "published": "2020-08-24", "journal": {"title": "Drug Alcohol Rev", "issn": "1465-3362", "volume": null, "issue": null, "issn-l": "0959-5236"}, "abstract": "Alcohol's impact on global health is substantial and of a similar order of magnitude to that from COVID-19. Alcohol now also poses specific concerns, such as increased risk of severe lung infections, domestic violence, child abuse, depression and suicide. Its use is unlikely to aid physical distancing or other preventative behavioural measures. Globally, alcohol contributes to 20% of injury and 11.5% of non-injury emergency room presentations. We provide some broad comparisons between alcohol-attributable and COVID-19-related hospitalisations and deaths in North America using most recent data. For example, for Canada in 2017 it was recently estimated there were 105 065 alcohol-attributable hospitalisations which represent a substantially higher rate over time than the 10 521 COVID-19 hospitalisations reported during the first 5 months of the pandemic. Despite the current importance of protecting health-care services, most governments have deemed alcohol sales to be as essential as food, fuel and pharmaceuticals. In many countries, alcohol is now more readily available and affordable than ever before, a situation global alcohol producers benefit from and have helped engineer. We argue that to protect frontline health-care services and public health more generally, it is essential that modest, evidence-based restrictions on alcohol prices, availability and marketing are introduced. In particular, we recommend increases in excise taxation coupled with minimum unit pricing to both reduce impacts on health-care services and provide much-needed revenues for governments at this critical time.", "doi": "10.1111/dar.13143", "pmid": "32835427", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7461236"}], "notes": [], "created": "2020-12-07T11:40:25.537Z", "modified": "2020-12-07T11:40:25.549Z"}, {"entity": "publication", "iuid": "5fcff184601b48c481ad4ca44cacbec0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5fcff184601b48c481ad4ca44cacbec0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5fcff184601b48c481ad4ca44cacbec0"}}, "title": "Immediate and long-term impact of the COVID-19 pandemic on delivery of surgical services", "authors": [{"family": "S\u00f8reide", "given": "K", "initials": "K", "orcid": "0000-0001-7594-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9c5655fc6aa437d91ed5cc2b4791543.json"}}, {"family": "Hallet", "given": "J", "initials": "J", "orcid": "0000-0001-5108-1072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f2eee26bb4744bec88785a9a46843a7b.json"}}, {"family": "Matthews", "given": "J B", "initials": "JB"}, {"family": "Schnitzbauer", "given": "A A", "initials": "AA"}, {"family": "Line", "given": "P D", "initials": "PD"}, {"family": "Lai", "given": "P B S", "initials": "PBS"}, {"family": "Otero", "given": "J", "initials": "J"}, {"family": "Callegaro", "given": "D", "initials": "D"}, {"family": "Warner", "given": "S G", "initials": "SG"}, {"family": "Baxter", "given": "N N", "initials": "NN"}, {"family": "Teh", "given": "C S C", "initials": "CSC"}, {"family": "Ng-Kamstra", "given": "J", "initials": "J"}, {"family": "Meara", "given": "J G", "initials": "JG"}, {"family": "Hagander", "given": "L", "initials": "L"}, {"family": "Lorenzon", "given": "L", "initials": "L", "orcid": "0000-0001-6736-0383", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2261efd5049432fa79781dece035f81.json"}}], "type": "journal-article", "published": "2020-08-24", "journal": {"title": "Br J Surg", "issn": "1365-2168", "volume": "107", "issue": "10", "pages": "1250-1261", "issn-l": null}, "abstract": "The ongoing pandemic is having a collateral health effect on delivery of surgical care to millions of patients. Very little is known about pandemic management and effects on other services, including delivery of surgery.\n\nThis was a scoping review of all available literature pertaining to COVID-19 and surgery, using electronic databases, society websites, webinars and preprint repositories.\n\nSeveral perioperative guidelines have been issued within a short time. Many suggestions are contradictory and based on anecdotal data at best. As regions with the highest volume of operations per capita are being hit, an unprecedented number of operations are being cancelled or deferred. No major stakeholder seems to have considered how a pandemic deprives patients with a surgical condition of resources, with patients disproportionally affected owing to the nature of treatment (use of anaesthesia, operating rooms, protective equipment, physical invasion and need for perioperative care). No recommendations exist regarding how to reopen surgical delivery. The postpandemic evaluation and future planning should involve surgical services as an essential part to maintain appropriate surgical care for the population during an outbreak. Surgical delivery, owing to its cross-cutting nature and synergistic effects on health systems at large, needs to be built into the WHO agenda for national health planning.\n\nPatients are being deprived of surgical access, with uncertain loss of function and risk of adverse prognosis as a collateral effect of the pandemic. Surgical services need a contingency plan for maintaining surgical care in an ongoing or postpandemic phase.", "doi": "10.1002/bjs.11670", "pmid": "32350857", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7267363"}], "notes": [], "created": "2020-11-30T15:53:12.325Z", "modified": "2021-12-06T12:58:21.582Z"}, {"entity": "publication", "iuid": "e34e09f4923d4ca98614c3edec114005", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e34e09f4923d4ca98614c3edec114005.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e34e09f4923d4ca98614c3edec114005"}}, "title": "Sex and gender: modifiers of health, disease, and medicine.", "authors": [{"family": "Mauvais-Jarvis", "given": "Franck", "initials": "F"}, {"family": "Bairey Merz", "given": "Noel", "initials": "N"}, {"family": "Barnes", "given": "Peter J", "initials": "PJ"}, {"family": "Brinton", "given": "Roberta D", "initials": "RD"}, {"family": "Carrero", "given": "Juan-Jesus", "initials": "JJ"}, {"family": "DeMeo", "given": "Dawn L", "initials": "DL"}, {"family": "De Vries", "given": "Geert J", "initials": "GJ"}, {"family": "Epperson", "given": "C Neill", "initials": "CN"}, {"family": "Govindan", "given": "Ramaswamy", "initials": "R"}, {"family": "Klein", "given": "Sabra L", "initials": "SL"}, {"family": "Lonardo", "given": "Amedeo", "initials": "A"}, {"family": "Maki", "given": "Pauline M", "initials": "PM"}, {"family": "McCullough", "given": "Louise D", "initials": "LD"}, {"family": "Regitz-Zagrosek", "given": "Vera", "initials": "V"}, {"family": "Regensteiner", "given": "Judith G", "initials": "JG"}, {"family": "Rubin", "given": "Joshua B", "initials": "JB"}, {"family": "Sandberg", "given": "Kathryn", "initials": "K"}, {"family": "Suzuki", "given": "Ayako", "initials": "A"}], "type": "journal article", "published": "2020-08-22", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "396", "issue": "10250", "pages": "565-582", "issn-l": "0140-6736"}, "abstract": "Clinicians can encounter sex and gender disparities in diagnostic and therapeutic responses. These disparities are noted in epidemiology, pathophysiology, clinical manifestations, disease progression, and response to treatment. This Review discusses the fundamental influences of sex and gender as modifiers of the major causes of death and morbidity. We articulate how the genetic, epigenetic, and hormonal influences of biological sex influence physiology and disease, and how the social constructs of gender affect the behaviour of the community, clinicians, and patients in the health-care system and interact with pathobiology. We aim to guide clinicians and researchers to consider sex and gender in their approach to diagnosis, prevention, and treatment of diseases as a necessary and fundamental step towards precision medicine, which will benefit men's and women's health.", "doi": "10.1016/S0140-6736(20)31561-0", "pmid": "32828189", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31561-0"}, {"db": "pmc", "key": "PMC7440877"}], "notes": [], "created": "2020-11-26T12:16:07.413Z", "modified": "2020-11-30T08:40:58.044Z"}, {"entity": "publication", "iuid": "9ca7de1ca24b481ab6dcc12f46bb0089", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ca7de1ca24b481ab6dcc12f46bb0089.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ca7de1ca24b481ab6dcc12f46bb0089"}}, "title": "Rapid Review of SARS-CoV-1 and SARS-CoV-2 Viability, Susceptibility to Treatment, and the Disinfection and Reuse of PPE, Particularly Filtering Facepiece Respirators.", "authors": [{"family": "Derraik", "given": "Jos\u00e9 G B", "initials": "JGB"}, {"family": "Anderson", "given": "William A", "initials": "WA"}, {"family": "Connelly", "given": "Elizabeth A", "initials": "EA"}, {"family": "Anderson", "given": "Yvonne C", "initials": "YC"}], "type": "journal article", "published": "2020-08-22", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "17", "issue": "17", "issn-l": null}, "abstract": "In the COVID-19 pandemic caused by SARS-CoV-2, hospitals are often stretched beyond capacity. There are widespread reports of dwindling supplies of personal protective equipment (PPE), particularly N95-type filtering facepiece respirators (FFRs), which are paramount to protect frontline medical/nursing staff, and to minimize further spread of the virus. We carried out a rapid review to summarize the existing literature on the viability of SARS-CoV-2, the efficacy of key potential disinfection procedures against the virus (specifically ultraviolet light and heat), and the impact of these procedures on FFR performance, material integrity, and/or fit. In light of the recent discovery of SARS-CoV-2 and limited associated research, our review also focused on the closely related SARS-CoV-1. We propose a possible whole-of-PPE disinfection solution for potential reuse that could be rapidly instituted in many health care settings, without significant investments in equipment.", "doi": "10.3390/ijerph17176117", "pmid": "32842655", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijerph17176117"}, {"db": "pmc", "key": "PMC7504573"}], "notes": [], "created": "2020-11-30T08:36:38.755Z", "modified": "2020-11-30T08:36:38.769Z"}, {"entity": "publication", "iuid": "7fd7c180f0204f0993b027f3d0d7bc81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7fd7c180f0204f0993b027f3d0d7bc81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7fd7c180f0204f0993b027f3d0d7bc81"}}, "title": "Natural killer cell immunotypes related to COVID-19 disease severity.", "authors": [{"family": "Maucourant", "given": "Christopher", "initials": "C", "orcid": "0000-0003-1033-2992", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb599f0df0bc42b88ddac10943ea3f6a.json"}}, {"family": "Filipovic", "given": "Iva", "initials": "I", "orcid": "0000-0002-8166-5500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c79974df90ae4fbf8be348b9b47d0317.json"}}, {"family": "Ponzetta", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3224-802X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8d6bca49dc24e558ca8f0b3637d7702.json"}}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Cornillet", "given": "Martin", "initials": "M", "orcid": "0000-0001-7981-0927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20d0c2fd2be843668806a91d2d83104b.json"}}, {"family": "Hertwig", "given": "Laura", "initials": "L", "orcid": "0000-0002-1170-0948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbc76f6fbe8b4fcebfa928374618b304.json"}}, {"family": "Strunz", "given": "Benedikt", "initials": "B"}, {"family": "Lentini", "given": "Antonio", "initials": "A", "orcid": "0000-0003-1239-5495", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8c1f3989ef84f6d9803fb30b3014dc4.json"}}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Brownlie", "given": "Demi", "initials": "D", "orcid": "0000-0001-5932-6425", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/099513dbc2004b41a5017db9fee6b0b3.json"}}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Ask", "given": "Eivind Heggernes", "initials": "EH", "orcid": "0000-0001-8655-1433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad160fa96dd94738a713f5c6934e61fa.json"}}, {"family": "Hull", "given": "Ryan M", "initials": "RM", "orcid": "0000-0001-7153-4198", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/957f3dfe66c6442d897faa0eb44a0975.json"}}, {"family": "Haroun-Izquierdo", "given": "Alvaro", "initials": "A", "orcid": "0000-0003-4557-3606", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb8c47d324cb44c0baf2c78e93d849d2.json"}}, {"family": "Schaffer", "given": "Marie", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Folkesson", "given": "Elin", "initials": "E", "orcid": "0000-0002-6585-6235", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a96b0fba760f4aee8e45d11b79ddf6e0.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}, {"family": "Sandberg", "given": "Johan K", "initials": "JK", "orcid": "0000-0002-6275-0750", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61225c074353413bb0b19c43b555732a.json"}}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Rooyackers", "given": "Olav", "initials": "O", "orcid": "0000-0002-3391-5448", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76700613a0f4410ab6c7d95658297e3f.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Malmberg", "given": "Karl-Johan", "initials": "KJ"}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Marquardt", "given": "Nicole", "initials": "N", "orcid": "0000-0003-3186-4752", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ac381a2857740708edf9145a7c5531c.json"}}, {"family": "Hammer", "given": "Quirin", "initials": "Q", "orcid": "0000-0003-2968-6061", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a71cf4c6d4d419daacba48ebd924238.json"}}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-8801-3169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37509c3832244b019b91a1fe2cbe183e.json"}}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4691d38f3268433696d7c65ea235a12b.json"}}, {"family": "Karolinska COVID-19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-21", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "issn-l": "2470-9468", "volume": "5", "issue": "50", "pages": null}, "abstract": "Understanding innate immune responses in COVID-19 is important to decipher mechanisms of host responses and interpret disease pathogenesis. Natural killer (NK) cells are innate effector lymphocytes that respond to acute viral infections but might also contribute to immunopathology. Using 28-color flow cytometry, we here reveal strong NK cell activation across distinct subsets in peripheral blood of COVID-19 patients. This pattern was mirrored in scRNA-seq signatures of NK cells in bronchoalveolar lavage from COVID-19 patients. Unsupervised high-dimensional analysis of peripheral blood NK cells furthermore identified distinct NK cell immunotypes that were linked to disease severity. Hallmarks of these immunotypes were high expression of perforin, NKG2C, and Ksp37, reflecting increased presence of adaptive NK cells in circulation of patients with severe disease. Finally, arming of CD56bright NK cells was observed across COVID-19 disease states, driven by a defined protein-protein interaction network of inflammatory soluble factors. This study provides a detailed map of the NK cell activation landscape in COVID-19 disease.", "doi": "10.1126/sciimmunol.abd6832", "pmid": "32826343", "labels": {"Type: Journal article": null, "Funder: VR: Special COVID-19 funding": null, "Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Diagnostics for virus": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Category: Imaging": null, "Category: Health": null, "Category: Other": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC7665314"}, {"db": "pii", "key": "5/50/eabd6832"}], "notes": [], "created": "2020-10-28T09:12:39.024Z", "modified": "2023-06-19T15:01:40.035Z"}, {"entity": "publication", "iuid": "8adf9c36ef8841da9896b05a4ca7eae2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8adf9c36ef8841da9896b05a4ca7eae2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8adf9c36ef8841da9896b05a4ca7eae2"}}, "title": "Universal Basic Income as a Policy Response to COVID-19 and Precarious Employment: Potential Impacts on Rehabilitation and Return-to-Work.", "authors": [{"family": "St\u00e5hl", "given": "Christian", "initials": "C"}, {"family": "MacEachen", "given": "Ellen", "initials": "E"}], "type": "editorial", "published": "2020-08-20", "journal": {"title": "J Occup Rehabil", "issn": "1573-3688", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1007/s10926-020-09923-w", "pmid": "32816204", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10926-020-09923-w"}, {"db": "pmc", "key": "PMC7439237"}], "notes": [], "created": "2020-12-07T12:47:13.419Z", "modified": "2020-12-07T12:47:13.439Z"}, {"entity": "publication", "iuid": "6d3514760222420687c2e3be578a7782", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6d3514760222420687c2e3be578a7782.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6d3514760222420687c2e3be578a7782"}}, "title": "Sex and age differences in COVID-19 mortality in Europe&nbsp.", "authors": [{"family": "Ahrenfeldt", "given": "Linda Juel", "initials": "LJ"}, {"family": "Otavova", "given": "Martina", "initials": "M"}, {"family": "Christensen", "given": "Kaare", "initials": "K"}, {"family": "Lindahl-Jacobsen", "given": "Rune", "initials": "R"}], "type": "preprint", "published": "2020-08-19", "journal": {"title": "Res Sq", "issn": null, "volume": null, "issue": null, "issn-l": null}, "abstract": "To examine the magnitude of sex differences in survival from the Coronavirus Disease 2019 (COVID-19) in Europe across age and countries. We hypothesise that men have higher mortality than women at any given age, but that sex differences will decrease with age as only the strongest men survive to older ages. Aim: We used population data from Institut National D'\u00c9tudes D\u00e9mographiques on cumulative deaths due to COVID-19 from February to June 2020 in 10 European countries: Denmark, Norway, Sweden, The Netherlands, England & Wales, France, Germany, Italy, Spain and Portugal. For each country, we calculated cumulative mortality rates stratified by age and sex and corresponding relative risks for men vs. women. Methods: The relative risk of dying from COVID-19 was higher for men than for women in almost all age groups in all countries. The overall relative risk ranged from 1.11 (95% CI 1.01-1.23) in Portugal to 1.54 (95% CI 1.49-1.58) in France. In most countries, sex differences increased until ages 60-69 years, but decreased thereafter with the smallest sex difference at ages 80+. Results: Despite variability in data collection and time coverage among countries, we illustrate an overall similar pattern of sex differences in COVID-19 mortality in Europe.Conclusions:", "doi": "10.21203/rs.3.rs-61444/v1", "pmid": "32839767", "labels": {"Type: Preprint": null}, "xrefs": [{"db": "pmc", "key": "PMC7444295"}], "notes": [], "created": "2020-12-07T10:29:17.011Z", "modified": "2020-12-07T10:29:17.012Z"}, {"entity": "publication", "iuid": "473564f5c7634a5aa0fac6da9882b24d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/473564f5c7634a5aa0fac6da9882b24d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/473564f5c7634a5aa0fac6da9882b24d"}}, "title": "On-target versus off-target effects of drugs inhibiting the replication of SARS-CoV-2.", "authors": [{"family": "Sauvat", "given": "Allan", "initials": "A"}, {"family": "Ciccosanti", "given": "Fabiola", "initials": "F"}, {"family": "Colavita", "given": "Francesca", "initials": "F"}, {"family": "Di Rienzo", "given": "Martina", "initials": "M"}, {"family": "Castilletti", "given": "Concetta", "initials": "C"}, {"family": "Capobianchi", "given": "Maria Rosaria", "initials": "MR"}, {"family": "Kepp", "given": "Oliver", "initials": "O"}, {"family": "Zitvogel", "given": "Laurence", "initials": "L"}, {"family": "Fimia", "given": "Gian Maria", "initials": "GM"}, {"family": "Piacentini", "given": "Mauro", "initials": "M"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}], "type": "journal article", "published": "2020-08-19", "journal": {"title": "Cell Death Dis", "issn": "2041-4889", "issn-l": null, "volume": "11", "issue": "8", "pages": "656"}, "abstract": "The current epidemic of coronavirus disease-19 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) calls for the development of inhibitors of viral replication. Here, we performed a bioinformatic analysis of published and purported SARS-CoV-2 antivirals including imatinib mesylate that we found to suppress SARS-CoV-2 replication on Vero E6 cells and that, according to the published literature on other coronaviruses is likely to act on-target, as a tyrosine kinase inhibitor. We identified a cluster of SARS-CoV-2 antivirals with characteristics of lysosomotropic agents, meaning that they are lipophilic weak bases capable of penetrating into cells. These agents include cepharentine, chloroquine, chlorpromazine, clemastine, cloperastine, emetine, hydroxychloroquine, haloperidol, ML240, PB28, ponatinib, siramesine, and zotatifin (eFT226) all of which are likely to inhibit SARS-CoV-2 replication by non-specific (off-target) effects, meaning that they probably do not act on their 'official' pharmacological targets, but rather interfere with viral replication through non-specific effects on acidophilic organelles including autophagosomes, endosomes, and lysosomes. Imatinib mesylate did not fall into this cluster. In conclusion, we propose a tentative classification of SARS-CoV-2 antivirals into specific (on-target) versus non-specific (off-target) agents based on their physicochemical characteristics.", "doi": "10.1038/s41419-020-02842-x", "pmid": "32814759", "labels": {"Type: Journal article": null, "Funder: H2020": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41419-020-02842-x"}, {"db": "pmc", "key": "PMC7434849"}], "notes": [], "created": "2020-12-07T12:48:01.042Z", "modified": "2021-02-26T08:45:25.857Z"}, {"entity": "publication", "iuid": "8800fa8905744a2ca57d7934df8aa12f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8800fa8905744a2ca57d7934df8aa12f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8800fa8905744a2ca57d7934df8aa12f"}}, "title": "Labile PT-INR in a Covid-19 Patient Under Long-term Vitamin K Antagonist Therapy: a Case Report.", "authors": [{"family": "Trevisan", "given": "Caterina", "initials": "C"}, {"family": "Miconi", "given": "Lorella", "initials": "L"}, {"family": "Barbierato", "given": "Emanuele", "initials": "E"}, {"family": "Marinaro", "given": "Giuseppe", "initials": "G"}, {"family": "Targhetta", "given": "Stefano", "initials": "S"}, {"family": "D'agata", "given": "Mario", "initials": "M"}, {"family": "Rinaldi", "given": "Daniela", "initials": "D"}], "type": "journal article", "published": "2020-08-19", "journal": {"title": "SN Compr Clin Med", "issn": "2523-8973", "volume": null, "issue": null, "pages": "1-3", "issn-l": null}, "abstract": "The COronaVIrus Disease-19 (COVID-19) has been associated with thromboembolic complications, but evidence on its impact on hemorrhagic risk are still scarce. We describe a case of COVID-19 with hemorrhagic complication in the post-acute phase of the disease. The patient was a 93-year-old woman admitted to a post-acute care unit for COVID-19 patients in northern Italy. The patient's medical history included moderate cognitive impairment, atrial fibrillation under oral anticoagulation (warfarin 2.5 mg and 3.75 mg on alternate days, showing stable PT-INR values since October 2018), and arterial hypertension. The patient was affected by COVID-19, treated with supportive therapy. In the post-acute phase of the disease, the patient presented with melena and showed a marked elevation of PT-INR of 25.1. She was treated with venous infusion of three-factor prothrombin complex concentrate and vitamin K until PT-INR reduction. After 5 days, blood analyses revealed normal hemoglobin, PT-INR 2.15, and a slight alteration of liver function. This case supports a strong impact of the infection on the coagulative pattern not only pro-thrombotically but also by increasing hemorrhagic risk. Special attention should therefore be paid to COVID-19 patients under anticoagulation with vitamin K antagonist and a shift to heparin treatment until illness resolution may be a safe option in these individuals.", "doi": "10.1007/s42399-020-00460-4", "pmid": "32839751", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "460"}, {"db": "pmc", "key": "PMC7437640"}], "notes": [], "created": "2020-12-07T10:30:37.675Z", "modified": "2021-02-26T08:45:48.432Z"}, {"entity": "publication", "iuid": "32aab714fa474fba9d9f2878a97e395d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/32aab714fa474fba9d9f2878a97e395d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/32aab714fa474fba9d9f2878a97e395d"}}, "title": "The COVID-19 Pandemic and Its Impact on Children in Domestic Violence Refuges.", "authors": [{"family": "\u00d8verlien", "given": "Carolina", "initials": "C"}], "type": "journal article", "published": "2020-08-18", "journal": {"title": "Child Abuse Rev", "issn": "1099-0852", "volume": null, "issue": null, "issn-l": null}, "abstract": "The COVID-19 pandemic has resulted in negative consequences for children exposed to violence and abuse.Domestic violence refuge staff were greatly concerned about children both living outside and inside refuges.Domestic violence refuges have played a pivotal role during the COVID-19 pandemic and should receive wider acknowledgement and greater support for their work.", "doi": "10.1002/car.2650", "pmid": "32904999", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "CAR2650"}, {"db": "pmc", "key": "PMC7461223"}], "notes": [], "created": "2020-12-03T16:14:23.593Z", "modified": "2020-12-03T16:14:23.619Z"}, {"entity": "publication", "iuid": "7da622d92e2046018ed3ea5aeb2c889a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7da622d92e2046018ed3ea5aeb2c889a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7da622d92e2046018ed3ea5aeb2c889a"}}, "title": "Nanoscale Structural Characterization of Individual Viral Particles Using Atomic Force Microscopy Infrared Spectroscopy (AFM-IR) and Tip-Enhanced Raman Spectroscopy (TERS).", "authors": [{"family": "Dou", "given": "Tianyi", "initials": "T"}, {"family": "Li", "given": "Zhandong", "initials": "Z"}, {"family": "Zhang", "given": "Junjie", "initials": "J"}, {"family": "Evilevitch", "given": "Alex", "initials": "A"}, {"family": "Kurouski", "given": "Dmitry", "initials": "D"}], "type": "journal article", "published": "2020-08-18", "journal": {"title": "Anal Chem", "issn": "1520-6882", "volume": "92", "issue": "16", "pages": "11297-11304", "issn-l": null}, "abstract": "Viruses are infections species that infect a large spectrum of living systems. Although displaying a wide variety of shapes and sizes, they are all composed of nucleic acid encapsulated into a protein capsid. After virions enter the host cell, they replicate to produce multiple copies of themselves. They then lyse the host, releasing virions to infect new cells. The high proliferation rate of viruses is the underlying cause of their fast transmission among living species. Although many viruses are harmless, some of them are responsible for severe diseases such as AIDS, viral hepatitis, and flu. Traditionally, electron microscopy is used to identify and characterize viruses. This approach is time- and labor-consuming, which is problematic upon pandemic proliferation of previously unknown viruses, such as H1N1 and COVID-19. Herein, we demonstrate a novel diagnosis approach for label-free identification and structural characterization of individual viruses that is based on a combination of nanoscale Raman and infrared spectroscopy. Using atomic force microscopy-infrared (AFM-IR) spectroscopy, we were able to probe structural organization of the virions of Herpes Simplex Type 1 viruses and bacteriophage MS2. We also showed that tip-enhanced Raman spectroscopy (TERS) could be used to reveal protein secondary structure and amino acid composition of the virus surface. Our results show that AFM-IR and TERS provide different but complementary information about the structure of complex biological specimens. This structural information can be used for fast and reliable identification of viruses. This nanoscale bimodal imaging approach can be also used to investigate the origin of viral polymorphism and study mechanisms of virion assembly.", "doi": "10.1021/acs.analchem.0c01971", "pmid": "32683857", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-07T16:31:16.731Z", "modified": "2021-02-26T08:46:13.317Z"}, {"entity": "publication", "iuid": "6cb1c940d5e1434493243bf243fe4e1b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6cb1c940d5e1434493243bf243fe4e1b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6cb1c940d5e1434493243bf243fe4e1b"}}, "title": "Hyperinflammation and Fibrosis in Severe COVID-19 Patients: Galectin-3, a Target Molecule to Consider.", "authors": [{"family": "Garcia-Revilla", "given": "Juan", "initials": "J"}, {"family": "Deierborg", "given": "Tomas", "initials": "T"}, {"family": "Venero", "given": "Jose Luis", "initials": "JL"}, {"family": "Boza-Serrano", "given": "Antonio", "initials": "A"}], "type": "journal article", "published": "2020-08-18", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "11", "issue": null, "pages": "2069"}, "abstract": "COVID-19 disease have become so far the most important sanitary crisis in the XXI century. In light of the events, any clinical resource should be considered to alleviate this crisis. Severe COVID-19 cases present a so-called cytokine storm as the most life-threatening symptom accompanied by lung fibrosis. Galectin-3 has been widely described as regulator of both processes. Hereby, we present compelling evidences on the potential role of galectin-3 in COVID-19 in the regulation of the inflammatory response, fibrosis and infection progression. Moreover, we provide a strong rationale of the utility of measuring plasma galectin-3 as a prognosis biomarker for COVID-19 patients and propose that inhibition of galectin-3 represents a feasible and promising new therapeutical approach.", "doi": "10.3389/fimmu.2020.02069", "pmid": "32973815", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7461806"}], "notes": [], "created": "2020-12-03T14:47:58.464Z", "modified": "2021-02-26T08:45:48.289Z"}, {"entity": "publication", "iuid": "02e13799c10c47cfbba71fec75ea0714", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02e13799c10c47cfbba71fec75ea0714.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02e13799c10c47cfbba71fec75ea0714"}}, "title": "A picture of medically assisted reproduction activities during the COVID-19 pandemic in Europe.", "authors": [{"family": "ESHRE COVID-19 Working Group ", "given": "", "initials": ""}, {"family": "Vermeulen", "given": "Nathalie", "initials": "N"}, {"family": "Ata", "given": "Baris", "initials": "B"}, {"family": "Gianaroli", "given": "Luca", "initials": "L"}, {"family": "Lundin", "given": "Kersti", "initials": "K"}, {"family": "Mocanu", "given": "Edgar", "initials": "E"}, {"family": "Rautakallio-Hokkanen", "given": "Satu", "initials": "S"}, {"family": "Tapanainen", "given": "Juha S", "initials": "JS"}, {"family": "Veiga", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2020-08-17", "journal": {"title": "Hum Reprod Open", "issn": "2399-3529", "volume": "2020", "issue": "3", "pages": "hoaa035", "issn-l": null}, "abstract": "How did coronavirus disease 2019 (COVID-19) impact on medically assisted reproduction (MAR) services in Europe during the COVID-19 pandemic (March to May 2020)?\n\nMAR services, and hence treatments for infertile couples, were stopped in most European countries for a mean of 7 weeks.\n\nWith the outbreak of COVID-19 in Europe, non-urgent medical care was reduced by local authorities to preserve health resources and maintain social distancing. Furthermore, ESHRE and other societies recommended to postpone ART pregnancies as of 14 March 2020.\n\nA structured questionnaire was distributed in April among the ESHRE Committee of National Representatives, followed by further information collection through email.\n\nThe information was collected through the questionnaire and afterwards summarised and aligned with data from the European Centre for Disease Control on the number of COVID-19 cases per country.\n\nBy aligning the data for each country with respective epidemiological data, we show a large variation in the time and the phase in the epidemic in the curve when MAR/ART treatments were suspended and restarted. Similarly, the duration of interruption varied. Fertility preservation treatments and patient supportive care for patients remained available during the pandemic.\n\nN/A.\n\nData collection was prone to misinterpretation of the questions and replies, and required further follow-up to check the accuracy. Some representatives reported that they, themselves, were not always aware of the situation throughout the country or reported difficulties with providing single generalised replies, for instance when there were regional differences within their country.\n\nThe current article provides a basis for further research of the different strategies developed in response to the COVID-19 crisis. Such conclusions will be invaluable for health authorities and healthcare professionals with respect to future similar situations.\n\nThere was no funding for the study, apart from technical support from ESHRE. The authors had no COI to disclose.", "doi": "10.1093/hropen/hoaa035", "pmid": "32821857", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "hoaa035"}, {"db": "pmc", "key": "PMC7430925"}], "notes": [], "created": "2020-12-07T12:20:35.064Z", "modified": "2020-12-07T12:20:35.086Z"}, {"entity": "publication", "iuid": "0c7d3bc6eeb44d1ca499293fdc7c0606", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c7d3bc6eeb44d1ca499293fdc7c0606.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c7d3bc6eeb44d1ca499293fdc7c0606"}}, "title": "Treatment of COVID-19 by Inhaled NO to Reduce Shunt?", "authors": [{"family": "Hedenstierna", "given": "G\u00f6ran", "initials": "G"}, {"family": "Chen", "given": "Luni", "initials": "L"}, {"family": "Hedenstierna", "given": "Magnus", "initials": "M"}, {"family": "Scaramuzzo", "given": "Gaetano", "initials": "G"}], "type": "letter", "published": "2020-08-15", "journal": {"title": "Am J Respir Crit Care Med", "issn": "1535-4970", "volume": "202", "issue": "4", "pages": "618", "issn-l": "1073-449X"}, "abstract": null, "doi": "10.1164/rccm.202004-0940LE", "pmid": "32579020", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7427390"}], "notes": [], "created": "2020-11-22T08:37:07.315Z", "modified": "2021-02-26T08:46:12.908Z"}, {"entity": "publication", "iuid": "86e22203b5eb4143a5423f1e195fd35d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86e22203b5eb4143a5423f1e195fd35d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86e22203b5eb4143a5423f1e195fd35d"}}, "title": "Untapped resources for medical research.", "authors": [{"family": "P\u00e9rez-Escobar", "given": "Oscar A", "initials": "OA"}, {"family": "Richardson", "given": "James E", "initials": "JE"}, {"family": "Howes", "given": "Melanie-Jayne R", "initials": "MR"}, {"family": "Lucas", "given": "Eve", "initials": "E"}, {"family": "\u00c1lvarez de R\u00f3man", "given": "Noelia", "initials": "N"}, {"family": "Collemare", "given": "J\u00e9r\u00f4me", "initials": "J"}, {"family": "Graham", "given": "Ian A", "initials": "IA"}, {"family": "Gratzfeld", "given": "Joachim", "initials": "J"}, {"family": "Kersey", "given": "Paul J", "initials": "PJ"}, {"family": "Leitch", "given": "Ilia J", "initials": "IJ"}, {"family": "Paton", "given": "Alan", "initials": "A"}, {"family": "Hollingsworth", "given": "Peter M", "initials": "PM"}, {"family": "Antonelli", "given": "Alexandre", "initials": "A"}], "type": "letter", "published": "2020-08-14", "journal": {"title": "Science", "issn": "1095-9203", "volume": "369", "issue": "6505", "pages": "781-782", "issn-l": "0036-8075"}, "abstract": null, "doi": "10.1126/science.abc8085", "pmid": "32792391", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "369/6505/781"}], "notes": [], "created": "2020-12-07T13:24:59.238Z", "modified": "2020-12-07T13:24:59.247Z"}, {"entity": "publication", "iuid": "d86a1fd91cdf4b48a66560ce4eea9a30", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d86a1fd91cdf4b48a66560ce4eea9a30.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d86a1fd91cdf4b48a66560ce4eea9a30"}}, "title": "A mathematical model reveals the influence of population heterogeneity on herd immunity to SARS-CoV-2.", "authors": [{"family": "Britton", "given": "Tom", "initials": "T", "orcid": "0000-0002-9228-7357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3953e83bbffb428ab0a02f335979acb2.json"}}, {"family": "Ball", "given": "Frank", "initials": "F", "orcid": "0000-0002-5599-2903", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a08214bb29404f58b5286d6d1368b3e4.json"}}, {"family": "Trapman", "given": "Pieter", "initials": "P", "orcid": "0000-0003-0569-1659", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a2df9c9216143cd8219de8687414709.json"}}], "type": "journal article", "published": "2020-08-14", "journal": {"title": "Science", "issn": "1095-9203", "issn-l": "0036-8075", "volume": "369", "issue": "6505", "pages": "846-849"}, "abstract": "Despite various levels of preventive measures, in 2020, many countries have suffered severely from the coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Using a model, we show that population heterogeneity can affect disease-induced immunity considerably because the proportion of infected individuals in groups with the highest contact rates is greater than that in groups with low contact rates. We estimate that if R 0 = 2.5 in an age-structured community with mixing rates fitted to social activity, then the disease-induced herd immunity level can be ~43%, which is substantially less than the classical herd immunity level of 60% obtained through homogeneous immunization of the population. Our estimates should be interpreted as an illustration of how population heterogeneity affects herd immunity rather than as an exact value or even a best estimate.", "doi": "10.1126/science.abc6810", "pmid": "32576668", "labels": {"Funder: VR: Special COVID-19 funding": null, "Type: Journal article": null, "Funder: VR": null, "Funder: NordForsk": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7331793"}, {"db": "pii", "key": "science.abc6810"}], "notes": [], "created": "2020-12-04T09:13:31.584Z", "modified": "2023-06-19T15:26:16.461Z"}, {"entity": "publication", "iuid": "c17d5d63db7a4237b23fb9c1bfdf17fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c17d5d63db7a4237b23fb9c1bfdf17fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c17d5d63db7a4237b23fb9c1bfdf17fc"}}, "title": "Mismatch between circulating cytokines and spontaneous cytokine production by leukocytes in hyperinflammatory COVID-19.", "authors": [{"family": "Kahn", "given": "Robin", "initials": "R"}, {"family": "Schmidt", "given": "Tobias", "initials": "T"}, {"family": "Golestani", "given": "Karan", "initials": "K"}, {"family": "Mossberg", "given": "Anki", "initials": "A"}, {"family": "Gullstrand", "given": "Birgitta", "initials": "B"}, {"family": "Bengtsson", "given": "Anders A", "initials": "AA"}, {"family": "Kahn", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2020-08-13", "journal": {"title": "J Leukoc Biol", "issn": "1938-3673", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The disease COVID-19 has developed into a worldwide pandemic. Hyperinflammation and high levels of several cytokines, for example, IL-6, are observed in severe COVID-19 cases. However, little is known about the cellular origin of these cytokines. Here, we investigated whether circulating leukocytes from patients with COVID-19 had spontaneous cytokine production. Patients with hyperinflammatory COVID-19 (n = 6) and sepsis (n = 3) were included at Sk\u00e5ne University Hospital, Sweden. Healthy controls were also recruited (n = 5). Cytokines were measured in COVID-19 and sepsis patients using an Immulite immunoassay system. PBMCs were cultured with brefeldin A to allow cytokine accumulation. In parallel, LPS was used as an activator. Cells were analyzed for cytokines and surface markers by flow cytometry. High levels of IL-6 and measurable levels of IL-8 and TNF, but not IL-1\u03b2, were observed in COVID-19 patients. Monocytes from COVID-19 patients had spontaneous production of IL-1\u03b2 and IL-8 (P = 0.0043), but not of TNF and IL-6, compared to controls. No spontaneous cytokine production was seen in lymphocytes from either patients or controls. Activation with LPS resulted in massive cytokine production by monocytes from COVID-19 patients and healthy controls, but not from sepsis patients. Finally, monocytes from COVID-19 patients produced more IL-1\u03b2 than from healthy controls (P = 0.0087) when activated. In conclusion, monocytes contribute partly to the ongoing hyperinflammation by production of IL-1\u03b2 and IL-8. Additionally, they are responsive to further activation. This data supports the notion of IL-1\u03b2 blockade in treatment of COVID-19. However, the source of the high levels of IL-6 remains to be determined.", "doi": "10.1002/JLB.5COVBCR0720-310RR", "pmid": "32794348", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7436862"}], "notes": [], "created": "2020-12-07T13:23:36.003Z", "modified": "2021-02-26T08:45:48.663Z"}, {"entity": "publication", "iuid": "cc3dfab3c1e149f682adb6e8c95794e5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc3dfab3c1e149f682adb6e8c95794e5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc3dfab3c1e149f682adb6e8c95794e5"}}, "title": "Does Self-isolation Violate the Right to Liberty? An Analysis of the European Court of Human Rights' Practice in Light of the Ukrainian Experience.", "authors": [{"family": "Litins'ka", "given": "Yana", "initials": "Y"}, {"family": "Karpenko", "given": "Oleksandra", "initials": "O"}], "type": "journal article", "published": "2020-08-13", "journal": {"title": "Eur J Health Law", "issn": "1571-8093", "issn-l": null, "volume": "27", "issue": "4", "pages": "368-385"}, "abstract": "COVID-19 became a stress-test for many legal systems because it required that a balance be found between rapid action to prevent the spread of the disease, and continued respect for human rights. Many states in Europe, including Ukraine, chose to enforce an obligation to self-isolate. In this article we review what the obligation to self-isolate entails in the case of Ukraine. We also analyse whether such an obligation should be viewed as a deprivation or a mere restriction of liberty, and if it is permissible under the European Convention for the Protection of Human Rights and Fundamental Freedoms.", "doi": "10.1163/15718093-BJA10024", "pmid": "33652392", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-03-03T17:02:20.206Z", "modified": "2022-11-10T07:09:04.422Z"}, {"entity": "publication", "iuid": "57f235418d50452785b82c709625d36a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/57f235418d50452785b82c709625d36a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/57f235418d50452785b82c709625d36a"}}, "title": "Key questions for modelling COVID-19 exit strategies.", "authors": [{"family": "Thompson", "given": "Robin N", "initials": "RN", "orcid": "0000-0001-8545-5212", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/463364e1efea442ca7c3c0964b5b7c88.json"}}, {"family": "Hollingsworth", "given": "T D\u00e9irdre", "initials": "TD", "orcid": "0000-0001-5962-4238", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d01e91cbf744ad4aa5c10b36df42255.json"}}, {"family": "Isham", "given": "Valerie", "initials": "V"}, {"family": "Arribas-Bel", "given": "Daniel", "initials": "D"}, {"family": "Ashby", "given": "Ben", "initials": "B", "orcid": "0000-0001-5588-7081", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e962d6776bb64ff6bd6d7a776c7323dd.json"}}, {"family": "Britton", "given": "Tom", "initials": "T"}, {"family": "Challenor", "given": "Peter", "initials": "P", "orcid": "0000-0001-8661-2718", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b5d358c6c484ede8d2d1b95c69b3281.json"}}, {"family": "Chappell", "given": "Lauren H K", "initials": "LHK"}, {"family": "Clapham", "given": "Hannah", "initials": "H"}, {"family": "Cunniffe", "given": "Nik J", "initials": "NJ", "orcid": "0000-0002-3533-8672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f49041a1dab140f1ab8ed5c8b9c0d502.json"}}, {"family": "Dawid", "given": "A Philip", "initials": "AP", "orcid": "0000-0002-7410-6882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc052cc3ab66498e9d301c0508504f51.json"}}, {"family": "Donnelly", "given": "Christl A", "initials": "CA"}, {"family": "Eggo", "given": "Rosalind M", "initials": "RM", "orcid": "0000-0002-0362-6717", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f186dc5f7947456bb8ff489e19247592.json"}}, {"family": "Funk", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-2842-3406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f03dcbc41884648a4eac5892852899a.json"}}, {"family": "Gilbert", "given": "Nigel", "initials": "N", "orcid": "0000-0002-5937-2410", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b438f3904e94df3be0a7371d0c5fb0a.json"}}, {"family": "Glendinning", "given": "Paul", "initials": "P"}, {"family": "Gog", "given": "Julia R", "initials": "JR"}, {"family": "Hart", "given": "William S", "initials": "WS", "orcid": "0000-0002-2504-6860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35cc023f28a04e0b855d98ae0f6e6e12.json"}}, {"family": "Heesterbeek", "given": "Hans", "initials": "H"}, {"family": "House", "given": "Thomas", "initials": "T", "orcid": "0000-0001-5835-8062", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48eb00c619034823b5ffce15e341d79a.json"}}, {"family": "Keeling", "given": "Matt", "initials": "M", "orcid": "0000-0003-4639-4765", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f72880a3fc6a42828e1fefe724ea3d6d.json"}}, {"family": "Kiss", "given": "Istv\u00e1n Z", "initials": "IZ", "orcid": "0000-0003-1473-6644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2489413352f4748aa22dca0e980868f.json"}}, {"family": "Kretzschmar", "given": "Mirjam E", "initials": "ME"}, {"family": "Lloyd", "given": "Alun L", "initials": "AL", "orcid": "0000-0002-6389-6321", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b29752d31364120a4078e5222a33014.json"}}, {"family": "McBryde", "given": "Emma S", "initials": "ES"}, {"family": "McCaw", "given": "James M", "initials": "JM", "orcid": "0000-0002-2452-3098", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05468ff8cc244c989ddbb22d60028a48.json"}}, {"family": "McKinley", "given": "Trevelyan J", "initials": "TJ"}, {"family": "Miller", "given": "Joel C", "initials": "JC"}, {"family": "Morris", "given": "Martina", "initials": "M"}, {"family": "O'Neill", "given": "Philip D", "initials": "PD"}, {"family": "Parag", "given": "Kris V", "initials": "KV"}, {"family": "Pearson", "given": "Carl A B", "initials": "CAB", "orcid": "0000-0003-0701-7860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37a6ce9807dd405ba6480a80965ab6d2.json"}}, {"family": "Pellis", "given": "Lorenzo", "initials": "L"}, {"family": "Pulliam", "given": "Juliet R C", "initials": "JRC"}, {"family": "Ross", "given": "Joshua V", "initials": "JV", "orcid": "0000-0002-9918-8167", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15a5af493f004550bd0d431de09d7c1b.json"}}, {"family": "Tomba", "given": "Gianpaolo Scalia", "initials": "GS"}, {"family": "Silverman", "given": "Bernard W", "initials": "BW", "orcid": "0000-0002-4059-2376", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec963dc6df3d4fb68a842a7fde234aa2.json"}}, {"family": "Struchiner", "given": "Claudio J", "initials": "CJ"}, {"family": "Tildesley", "given": "Michael J", "initials": "MJ"}, {"family": "Trapman", "given": "Pieter", "initials": "P", "orcid": "0000-0003-0569-1659", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a2df9c9216143cd8219de8687414709.json"}}, {"family": "Webb", "given": "Cerian R", "initials": "CR"}, {"family": "Mollison", "given": "Denis", "initials": "D"}, {"family": "Restif", "given": "Olivier", "initials": "O", "orcid": "0000-0001-9158-853X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b62d897d36b42ba8bd57590d68d2899.json"}}], "type": "journal article", "published": "2020-08-12", "journal": {"title": "Proc Biol Sci", "issn": "1471-2954", "issn-l": null, "volume": "287", "issue": "1932", "pages": "20201405"}, "abstract": "Combinations of intense non-pharmaceutical interventions (lockdowns) were introduced worldwide to reduce SARS-CoV-2 transmission. Many governments have begun to implement exit strategies that relax restrictions while attempting to control the risk of a surge in cases. Mathematical modelling has played a central role in guiding interventions, but the challenge of designing optimal exit strategies in the face of ongoing transmission is unprecedented. Here, we report discussions from the Isaac Newton Institute 'Models for an exit strategy' workshop (11-15 May 2020). A diverse community of modellers who are providing evidence to governments worldwide were asked to identify the main questions that, if answered, would allow for more accurate predictions of the effects of different exit strategies. Based on these questions, we propose a roadmap to facilitate the development of reliable models to guide exit strategies. This roadmap requires a global collaborative effort from the scientific community and policymakers, and has three parts: (i) improve estimation of key epidemiological parameters; (ii) understand sources of heterogeneity in populations; and (iii) focus on requirements for data collection, particularly in low-to-middle-income countries. This will provide important information for planning exit strategies that balance socio-economic benefits with public health.", "doi": "10.1098/rspb.2020.1405", "pmid": "32781946", "labels": {"Type: Review": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC7575516"}], "notes": [], "created": "2020-11-30T08:41:04.303Z", "modified": "2023-06-19T15:26:28.252Z"}, {"entity": "publication", "iuid": "7bf0541d70e84f2da1fffa80763585ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7bf0541d70e84f2da1fffa80763585ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7bf0541d70e84f2da1fffa80763585ff"}}, "title": "Does the Prosperity of a Country Play a Role in COVID-19 Outcomes?", "authors": [{"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}, {"family": "Carlstr\u00f6m", "given": "Eric", "initials": "E"}, {"family": "Hertelendy", "given": "Attila J", "initials": "AJ"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}, {"family": "Casady", "given": "Carter B", "initials": "CB"}, {"family": "Burkle", "given": "Frederick M", "initials": "FM"}], "type": "journal article", "published": "2020-08-12", "journal": {"title": "Disaster Med Public Health Prep", "issn": "1938-744X", "issn-l": "1935-7893", "volume": null, "issue": null, "pages": "1-10"}, "abstract": "This study aims to clarify the association between prosperity and the coronavirus disease (COVID-19) outcomes and its impact on the future management of pandemics.\r\n\r\nThis is an observational study using information from 2 online registries. The numbers of infected individuals and deaths and the prosperity rank of each country were obtained from worldometer.info and the Legatum Institute's Prosperity Index, respectively.\r\n\r\nThere is a combination of countries with high and low prosperity on the list of COVID-19-infected countries. The risk of the virus pandemic seems to be more extensive in countries with high prosperity. A Spearman's rho test confirmed a significant correlation between prosperity, the number of COVID-19 cases, and the number of deaths at the 99% level.\r\n\r\nNew emerging pandemics affect all nations. In order to increase the likelihood of successfully managing future events, it is important to consider preexisting health security, valid population-based management approaches, medical decision-making, communication, continuous assessment, triage, treatment, early and complete physical distancing strategies, and logistics. These elements cannot be taught on-site and on occasion. There is a need for innovative and regular educational activities for all stakeholders committed to safeguarding our future defense systems concerning diagnostic, protection, treatment, and rehabilitation in pandemics, as well as other emergencies.", "doi": "10.1017/dmp.2020.304", "pmid": "32782059", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S1935789320003043"}, {"db": "pmc", "key": "PMC7477401"}], "notes": [], "created": "2020-12-07T13:29:22.810Z", "modified": "2022-11-10T07:09:49.459Z"}, {"entity": "publication", "iuid": "f232eaf8e0594f659f7ff3d2ea8bf32a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f232eaf8e0594f659f7ff3d2ea8bf32a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f232eaf8e0594f659f7ff3d2ea8bf32a"}}, "title": "Pronounced difference in Covid-19 antibody prevalence indicates cluster transmission in Stockholm, Sweden.", "authors": [{"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Hanson", "given": "Stefan", "initials": "S"}, {"family": "Olsen", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2020-08-11", "journal": {"title": "Infect Ecol Epidemiol", "issn": "2000-8686", "issn-l": "2000-8686", "volume": "10", "issue": "1", "pages": "1806505"}, "abstract": "The prevalence of COVID-19 antibodies on June 17-18, 2020 was investigated in two residential areas of Stockholm, Sweden. Among the residents in Norra Djurg\u00e5rdsstaden, a newly built upper- and middle-class area of Stockholm, 4.1% of study participants had SARS-CoV-2-specific antibodies, while in Tensta, a highly segregated low-income area, 30% of the participants tested antibody positive.", "doi": "10.1080/20008686.2020.1806505", "pmid": "32944166", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "1806505"}, {"db": "pmc", "key": "PMC7480443"}], "notes": [], "created": "2020-11-11T07:20:08.508Z", "modified": "2021-02-26T08:45:14.498Z"}, {"entity": "publication", "iuid": "420ece91e6c44fd8b90a235a80a7e4d3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/420ece91e6c44fd8b90a235a80a7e4d3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/420ece91e6c44fd8b90a235a80a7e4d3"}}, "title": "Obesity as a contributor to immunopathology in pregnant and non-pregnant adults with COVID-19.", "authors": [{"family": "McCartney", "given": "Stephen A", "initials": "SA"}, {"family": "Kachikis", "given": "Alisa", "initials": "A"}, {"family": "Huebner", "given": "Emily M", "initials": "EM"}, {"family": "Walker", "given": "Christie L", "initials": "CL"}, {"family": "Chandrasekaran", "given": "Suchi", "initials": "S"}, {"family": "Adams Waldorf", "given": "Kristina M", "initials": "KM"}], "type": "journal article", "published": "2020-08-11", "journal": {"title": "Am J Reprod Immunol", "issn": "1600-0897", "volume": null, "issue": null, "pages": "e13320", "issn-l": null}, "abstract": "The ongoing coronavirus disease 2019 (COVID-19) pandemic has led to a global public health emergency with the need to identify vulnerable populations who may benefit from increased screening and healthcare resources. Initial data suggest that overall, pregnancy is not a significant risk factor for severe coronavirus disease 2019 (COVID-19). However, case series have suggested that maternal obesity is one of the most important comorbidities associated with more severe disease. In obese individuals, suppressors of cytokine signaling are upregulated and type I and III interferon responses are delayed and blunted leading to ineffective viral clearance. Obesity is also associated with changes in systemic immunity involving a wide range of immune cells and mechanisms that lead to low-grade chronic inflammation, which can compromise antiviral immunity. Macrophage activation in adipose tissue can produce low levels of pro-inflammatory cytokines (TNF-\u03b1, IL-1\u03b2, IL-6). Further, adipocyte secretion of leptin is pro-inflammatory and high circulating levels of leptin have been associated with mortality in patients with acute respiratory distress syndrome. The synergistic effects of obesity-associated delays in immune control of COVID-19 with mechanical stress of increased adipose tissue may contribute to a greater risk of pulmonary compromise in obese pregnant women. In this review, we bring together data regarding obesity as a key co-morbidity for COVID-19 in pregnancy with known changes in the antiviral immune response associated with obesity. We also describe how the global burden of obesity among reproductive age women has serious public health implications for COVID-19.", "doi": "10.1111/aji.13320", "pmid": "32779790", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7435524"}], "notes": [], "created": "2020-11-30T08:41:05.562Z", "modified": "2020-11-30T08:41:05.587Z"}, {"entity": "publication", "iuid": "0e58ba01cbcf49a091eabdf7e0ffa9c1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e58ba01cbcf49a091eabdf7e0ffa9c1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e58ba01cbcf49a091eabdf7e0ffa9c1"}}, "title": "Laparoscopic Surgery and the debate on its safety during COVID-19 pandemic: A systematic review of recommendations.", "authors": [{"family": "El Boghdady", "given": "Michael", "initials": "M"}, {"family": "Ewalds-Kvist", "given": "Beatrice Marianne", "initials": "BM"}], "type": "journal article", "published": "2020-08-11", "journal": {"title": "Surgeon", "issn": "1479-666X", "volume": null, "issue": null, "issn-l": null}, "abstract": "The transmission of COVID-19 virus since the outbreak of viral pneumonia due to SARS-CoV-2 gave rise to protective operative measures. Aerosol generating procedures such as laparoscopic surgery are known to be associated with increased risks of viral transmission to the healthcare workers. The safety of laparoscopy during the pandemic was then debated. We aimed to systematically review the literature regarding the safe use of laparoscopy during COVID-19.\n\nWe performed a systematic search using PubMed and ScienceDirect databases from inception to 1st May, 2020. The following search terms were used: ''laparoscopic surgery and COVID-19''; ''minimally invasive surgery and COVID-19''. Search items were considered from the nature of the articles, date of publication, aims and findings in relation to use of laparoscopic surgery during COVID-19. The study protocol was registered with PROSPERO register for systematic reviews (CRD42020183432).\n\nAltogether, 174 relevant citations were identified and reviewed for this study, of which 22 articles were included. The analysis of the findings in relation to laparoscopic surgery during the pandemic were presented in tabular form. We completed the common recommendations for performing laparoscopy during the COVID-19 pandemic in forms of pre-, intra- and postoperative phases.\n\nThere is no scientific evidence to date for the transmission of COVID-19 by laparoscopic surgery. Laparoscopy can be used with precautions because of its benefits compared to open surgery. If safe, conservative management is the primary alternative during the pandemic. We concluded that recommended precautions should be respected while performing laparoscopy during the pandemic.", "doi": "10.1016/j.surge.2020.07.005", "pmid": "32855070", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1479-666X(20)30104-9"}, {"db": "pmc", "key": "PMC7418789"}], "notes": [], "created": "2020-11-30T08:36:34.178Z", "modified": "2020-11-30T08:36:34.199Z"}, {"entity": "publication", "iuid": "50dc122d0f144aa1b9ccd32a5da53091", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50dc122d0f144aa1b9ccd32a5da53091.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50dc122d0f144aa1b9ccd32a5da53091"}}, "title": "Comprehensive Overview on Multiple Strategies Fighting COVID-19.", "authors": [{"family": "Khalifa", "given": "Shaden A M", "initials": "SAM"}, {"family": "Mohamed", "given": "Briksam S", "initials": "BS"}, {"family": "Elashal", "given": "Mohamed H", "initials": "MH"}, {"family": "Du", "given": "Ming", "initials": "M"}, {"family": "Guo", "given": "Zhiming", "initials": "Z"}, {"family": "Zhao", "given": "Chao", "initials": "C"}, {"family": "Musharraf", "given": "Syed Ghulam", "initials": "SG"}, {"family": "Boskabady", "given": "Mohammad H", "initials": "MH"}, {"family": "El-Seedi", "given": "Haged H R", "initials": "HHR"}, {"family": "Efferth", "given": "Thomas", "initials": "T"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}], "type": "journal article", "published": "2020-08-11", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "17", "issue": "16", "issn-l": null}, "abstract": "Lately, myriad of novel viruses have emerged causing epidemics such as SARS, MERS, and SARS-CoV-2, leading to high mortality rates worldwide. Thus, these viruses represented a challenging threat to mankind, especially considering the miniscule data available at our disposal regarding these novel viruses. The entire world established coordinative relations in research projects regarding drug and vaccine development on the external range, whereas on the internal range, all countries declared it an emergency case through imposing different restrictions related to their border control, large gatherings, school attendance, and most social activities. Pandemic combating plans prioritized all sectors including normal people, medical staff politicians, and scientists collectively shouldered the burden. Through planning and learning the previous lessons from SARS and MERS, healthcare systems could succeed in combating the viral spread and implications of these new pandemics. Different management strategies including social distance, social awareness and isolation represented successful ways to slow down the spread of the pandemic. Furthermore, pre-preparedness of some countries for emergencies is crucial to minimize the consequences of the crisis.", "doi": "10.3390/ijerph17165813", "pmid": "32796733", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijerph17165813"}, {"db": "pmc", "key": "PMC7460286"}], "notes": [], "created": "2020-11-30T08:41:00.511Z", "modified": "2020-11-30T08:41:00.525Z"}, {"entity": "publication", "iuid": "1e17e4cbd29741e2aa6ca44f3c385dab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1e17e4cbd29741e2aa6ca44f3c385dab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1e17e4cbd29741e2aa6ca44f3c385dab"}}, "title": "Children's Anxiety and Factors Related to the COVID-19 Pandemic: An Exploratory Study Using the Children's Anxiety Questionnaire and the Numerical Rating Scale.", "authors": [{"family": "Garcia de Avila", "given": "Marla Andr\u00e9ia", "initials": "MA"}, {"family": "Hamamoto Filho", "given": "Pedro Tadao", "initials": "PT"}, {"family": "Jacob", "given": "Francine Let\u00edcia da Silva", "initials": "FLdS"}, {"family": "Alcantara", "given": "L\u00e9ia Regina Souza", "initials": "LRS"}, {"family": "Berghammer", "given": "Malin", "initials": "M"}, {"family": "Jenholt Nolbris", "given": "Margaretha", "initials": "M"}, {"family": "Olaya-Contreras", "given": "Patricia", "initials": "P"}, {"family": "Nilsson", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2020-08-09", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "16", "pages": null}, "abstract": "The repercussions of the COVID-19 pandemic on children's lives deserve attention. This study aimed to assess the prevalence of anxiety among Brazilian children and its associated factors during social distancing during COVID-19. We used a cross-sectional design with an online survey from April to May 2020 in Brazil. We included children aged 6-12 years and their guardians. The Children's Anxiety Questionnaire (CAQ; scores 4-12) and the Numerical Rating Scale (NRS; scores 0-10) were used to measure anxiety. We enrolled 157 girls and 132 boys, with a mean age of 8.84 (\u00b12.05) years; 88.9% of respondents were mothers. Based on CAQ \u2265 9, the prevalence of anxiety was 19.4% (n = 56), and higher among children with parents with essential jobs and those who were social distancing without parents. In logistic regression, the following variables were associated with higher CAQ scores: social distancing without parents; more persons living together in home; and education level of guardians. Based on NRS > 7, the prevalence of anxiety was 21.8% (n = 63); however, no associations with NRS scores were found with the investigated variables. These findings suggest the necessity of implementing public health actions targeting these parents and their children at the population level.", "doi": "10.3390/ijerph17165757", "pmid": "32784898", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "ijerph17165757"}, {"db": "pmc", "key": "PMC7459447"}], "notes": [], "created": "2020-12-07T13:28:53.440Z", "modified": "2022-11-10T07:11:07.153Z"}, {"entity": "publication", "iuid": "a94013a0dc4a4d148aa66becf6e8a548", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a94013a0dc4a4d148aa66becf6e8a548.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a94013a0dc4a4d148aa66becf6e8a548"}}, "title": "Symptoms of burnout in intensive care unit specialists facing the COVID-19 outbreak.", "authors": [{"family": "Azoulay", "given": "Elie", "initials": "E"}, {"family": "De Waele", "given": "Jan", "initials": "J"}, {"family": "Ferrer", "given": "Ricard", "initials": "R"}, {"family": "Staudinger", "given": "Thomas", "initials": "T"}, {"family": "Borkowska", "given": "Marta", "initials": "M"}, {"family": "Povoa", "given": "Pedro", "initials": "P"}, {"family": "Iliopoulou", "given": "Katerina", "initials": "K"}, {"family": "Artigas", "given": "Antonio", "initials": "A"}, {"family": "Schaller", "given": "Stefan J", "initials": "SJ"}, {"family": "Hari", "given": "Manu Shankar", "initials": "MS"}, {"family": "Pellegrini", "given": "Mariangela", "initials": "M"}, {"family": "Darmon", "given": "Michael", "initials": "M"}, {"family": "Kesecioglu", "given": "Jozef", "initials": "J"}, {"family": "Cecconi", "given": "Maurizio", "initials": "M"}, {"family": "ESICM", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-08", "journal": {"title": "Ann Intensive Care", "issn": "2110-5820", "volume": "10", "issue": "1", "pages": "110", "issn-l": null}, "abstract": "The COVID-19 pandemic has resulted in an unprecedented healthcare crisis with a high prevalence of psychological distress in healthcare providers. We sought to document the prevalence of burnout syndrome amongst intensivists facing the COVID-19 outbreak.\n\nCross-sectional survey among intensivists part of the European Society of Intensive Care Medicine. Symptoms of severe burnout, anxiety and depression were collected. Factors independently associated with severe burnout were assessed using Cox model.\n\nResponse rate was 20% (1001 completed questionnaires were returned, 45 years [39-53], 34% women, from 85 countries, 12 regions, 50% university-affiliated hospitals). The prevalence of symptoms of anxiety and depression or severe burnout was 46.5%, 30.2%, and 51%, respectively, and varied significantly across regions. Rating of the relationship between intensivists and other ICU stakeholders differed significantly according to the presence of anxiety, depression, or burnout. Similar figures were reported for their rating of the ethical climate or the quality of the decision-making. Factors independently associated with anxiety were female gender (HR 1.85 [1.33-2.55]), working in a university-affiliated hospital (HR 0.58 [0.42-0.80]), living in a city of > 1 million inhabitants (HR 1.40 [1.01-1.94]), and clinician's rating of the ethical climate (HR 0.83 [0.77-0.90]). Independent determinants of depression included female gender (HR 1.63 [1.15-2.31]) and clinician's rating of the ethical climate (HR 0.84 [0.78-0.92]). Factors independently associated with symptoms of severe burnout included age (HR 0.98/year [0.97-0.99]) and clinician's rating of the ethical climate (HR 0.76 [0.69-0.82]).\n\nThe COVID-19 pandemic has had an overwhelming psychological impact on intensivists. Follow-up, and management are warranted to assess long-term psychological outcomes and alleviate the psychological burden of the pandemic on frontline personnel.", "doi": "10.1186/s13613-020-00722-3", "pmid": "32770449", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13613-020-00722-3"}, {"db": "pmc", "key": "PMC7414284"}], "notes": [], "created": "2020-12-07T13:34:57.801Z", "modified": "2020-12-07T13:35:52.082Z"}, {"entity": "publication", "iuid": "fb03bfdb9d4845aa81ab5fc091a90b93", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb03bfdb9d4845aa81ab5fc091a90b93.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb03bfdb9d4845aa81ab5fc091a90b93"}}, "title": "COVID-19-a very visible pandemic.", "authors": [{"family": "King", "given": "Carina", "initials": "C"}, {"family": "Einhorn", "given": "Lena", "initials": "L"}, {"family": "Brusselaers", "given": "Nele", "initials": "N"}, {"family": "Carlsson", "given": "Marcus", "initials": "M"}, {"family": "Einhorn", "given": "Stefan", "initials": "S"}, {"family": "Elgh", "given": "Fredrik", "initials": "F"}, {"family": "Fris\u00e9n", "given": "Jonas", "initials": "J"}, {"family": "Gustafsson", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Hanson", "given": "Stefan", "initials": "S"}, {"family": "Hanson", "given": "Claudia", "initials": "C"}, {"family": "Hedner", "given": "Thomas", "initials": "T"}, {"family": "Isaksson", "given": "Olle", "initials": "O"}, {"family": "Jansson", "given": "Anders", "initials": "A"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "L\u00f6tvall", "given": "Jan", "initials": "J"}, {"family": "Lundback", "given": "Bo", "initials": "B"}, {"family": "Olsen", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "S\u00f6derberg-Naucl\u00e9r", "given": "Cecilia", "initials": "C"}, {"family": "Wahlin", "given": "Anders", "initials": "A"}, {"family": "Steineck", "given": "Gunner", "initials": "G"}, {"family": "Vahlne", "given": "Anders", "initials": "A"}], "type": "letter", "published": "2020-08-08", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "396", "issue": "10248", "pages": "e15", "issn-l": "0140-6736"}, "abstract": "Review", "doi": "10.1016/S0140-6736(20)31672-X", "pmid": "32771110", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31672-X"}], "notes": [], "created": "2020-11-11T07:18:55.672Z", "modified": "2020-12-07T13:34:19.209Z"}, {"entity": "publication", "iuid": "046b2eb278b84654a47ee7b17c847c38", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/046b2eb278b84654a47ee7b17c847c38.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/046b2eb278b84654a47ee7b17c847c38"}}, "title": "COVID-19-a very visible pandemic.", "authors": [{"family": "Lindahl", "given": "Johanna F", "initials": "JF"}, {"family": "Olsen", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "letter", "published": "2020-08-08", "journal": {"title": "Lancet", "issn": "1474-547X", "issn-l": "0140-6736", "volume": "396", "issue": "10248", "pages": "e16"}, "abstract": null, "doi": "10.1016/S0140-6736(20)31674-3", "pmid": "32771111", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31674-3"}], "notes": [], "created": "2020-11-18T17:16:56.095Z", "modified": "2020-12-11T12:51:30.151Z"}, {"entity": "publication", "iuid": "d45fc21e8154403c809bf4467cd00f70", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d45fc21e8154403c809bf4467cd00f70.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d45fc21e8154403c809bf4467cd00f70"}}, "title": "COVID-19-a very visible pandemic.", "authors": [{"family": "Ewing", "given": "Andrew", "initials": "A"}], "type": "letter", "published": "2020-08-08", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "396", "issue": "10248", "pages": "e18", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)31676-7", "pmid": "32771113", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31676-7"}], "notes": [], "created": "2020-12-07T13:34:10.903Z", "modified": "2020-12-07T13:34:10.913Z"}, {"entity": "publication", "iuid": "0c0569b2f3b942bd91e0c502e055ab57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c0569b2f3b942bd91e0c502e055ab57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c0569b2f3b942bd91e0c502e055ab57"}}, "title": "COVID-19-a very visible pandemic - Author's reply.", "authors": [{"family": "Giesecke", "given": "Johan", "initials": "J"}], "type": "letter", "published": "2020-08-08", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "396", "issue": "10248", "pages": "e20", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)31677-9", "pmid": "32771115", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31677-9"}], "notes": [], "created": "2020-12-07T13:33:42.158Z", "modified": "2020-12-07T13:33:42.170Z"}, {"entity": "publication", "iuid": "608402be419043abb6ab5e52ee0617a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/608402be419043abb6ab5e52ee0617a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/608402be419043abb6ab5e52ee0617a0"}}, "title": "The formidable task of fighting COVID-19 in Sudan.", "authors": [{"family": "Elhadi", "given": "Yasir Ahmed Mohammed", "initials": "YAM"}, {"family": "Adebisi", "given": "Yusuff Adebayo", "initials": "YA"}, {"family": "Hassan", "given": "Khlood Fathi", "initials": "KF"}, {"family": "Mohammed", "given": "Salma Elmukashfi Eltaher", "initials": "SEE"}, {"family": "Lin", "given": "Xu", "initials": "X"}, {"family": "Lucero-Prisno Iii", "given": "Don Eliseo", "initials": "DE"}], "type": "journal article", "published": "2020-08-07", "journal": {"title": "Pan Afr Med J", "issn": "1937-8688", "issn-l": null, "volume": "35", "issue": "Suppl 2", "pages": "137"}, "abstract": "Commentary\r\nSudan is facing a formidable task of fighting COVID-19. The country is suddenly challenged by this health issue that will test its path towards peace, stability, and development. The fragile task of handling COVID-19 epidemic in Sudan is brought about by several factors such as the weak healthcare system and political conflicts, that have been intertwined with the recent regime. Even before the COVID-19 pandemic, there was already high unemployment, soaring inflation and lack of social protection and safety nets for its populace. The government has been trying its best to address the pandemic, however, much still needs to be done. Neglecting Sudan by the international community in terms of support towards containment of COVID-19 has grievous implications for transition out of military dictatorship and efforts to curb the pandemic globally. As no country is safe if all is not safe. It is essential that Sudan should leverage on innovations, country-compatible measures, and other tailor-made strategies for effective responses.", "doi": "10.11604/pamj.supp.2020.35.137.24984", "pmid": "33193952", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "PAMJ-35-2-137"}, {"db": "pmc", "key": "PMC7608774"}], "notes": [], "created": "2020-11-30T16:14:57.847Z", "modified": "2020-12-11T12:51:48.786Z"}, {"entity": "publication", "iuid": "7a2b0ec035284b22995f88d44590c3be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a2b0ec035284b22995f88d44590c3be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a2b0ec035284b22995f88d44590c3be"}}, "title": "Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients.", "authors": [{"family": "Stebbing", "given": "Justin", "initials": "J"}, {"family": "Krishnan", "given": "Venkatesh", "initials": "V"}, {"family": "de Bono", "given": "Stephanie", "initials": "S"}, {"family": "Ottaviani", "given": "Silvia", "initials": "S"}, {"family": "Casalini", "given": "Giacomo", "initials": "G"}, {"family": "Richardson", "given": "Peter J", "initials": "PJ"}, {"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Lauschke", "given": "Volker M", "initials": "VM"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Youhanna", "given": "Sonia", "initials": "S"}, {"family": "Tan", "given": "Yee-Joo", "initials": "YJ"}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Sarasini", "given": "Antonella", "initials": "A"}, {"family": "Terres", "given": "Jorge A Ross", "initials": "JAR"}, {"family": "Nickoloff", "given": "Brian J", "initials": "BJ"}, {"family": "Higgs", "given": "Richard E", "initials": "RE"}, {"family": "Rocha", "given": "Guilherme", "initials": "G"}, {"family": "Byers", "given": "Nicole L", "initials": "NL"}, {"family": "Schlichting", "given": "Douglas E", "initials": "DE"}, {"family": "Nirula", "given": "Ajay", "initials": "A"}, {"family": "Cardoso", "given": "Anabela", "initials": "A"}, {"family": "Corbellino", "given": "Mario", "initials": "M"}, {"family": "Sacco Baricitinib Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-07", "journal": {"title": "EMBO Mol Med", "issn": "1757-4684", "volume": "12", "issue": "8", "pages": "e12697", "issn-l": "1757-4676"}, "abstract": "Baricitinib is an oral Janus kinase (JAK)1/JAK2 inhibitor approved for the treatment of rheumatoid arthritis (RA) that was independently predicted, using artificial intelligence (AI) algorithms, to be useful for COVID-19 infection via proposed anti-cytokine effects and as an inhibitor of host cell viral propagation. We evaluated the in vitro pharmacology of baricitinib across relevant leukocyte subpopulations coupled to its in vivo pharmacokinetics and showed it inhibited signaling of cytokines implicated in COVID-19 infection. We validated the AI-predicted biochemical inhibitory effects of baricitinib on human numb-associated kinase (hNAK) members measuring nanomolar affinities for AAK1, BIKE, and GAK. Inhibition of NAKs led to reduced viral infectivity with baricitinib using human primary liver spheroids. These effects occurred at exposure levels seen clinically. In a case series of patients with bilateral COVID-19 pneumonia, baricitinib treatment was associated with clinical and radiologic recovery, a rapid decline in SARS-CoV-2 viral load, inflammatory markers, and IL-6 levels. Collectively, these data support further evaluation of the anti-cytokine and anti-viral activity of baricitinib and support its assessment in randomized trials in hospitalized COVID-19 patients.", "doi": "10.15252/emmm.202012697", "pmid": "32473600", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7300657"}], "notes": [], "created": "2020-11-25T09:23:21.591Z", "modified": "2021-02-26T08:45:03.060Z"}, {"entity": "publication", "iuid": "145941fb72144cf3ae765c4b162cb89a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/145941fb72144cf3ae765c4b162cb89a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/145941fb72144cf3ae765c4b162cb89a"}}, "title": "Genetic and Phenotypic Evidence for the Causal Relationship Between Aging and COVID-19", "authors": [{"family": "Ying", "given": "Kejun", "initials": "K"}, {"family": "Zhai", "given": "Ranran", "initials": "R"}, {"family": "Pyrkov", "given": "Timothy V", "initials": "TV"}, {"family": "Mariotti", "given": "Marco", "initials": "M"}, {"family": "Fedichev", "given": "Peter O", "initials": "PO"}, {"family": "Shen", "given": "Xia", "initials": "X"}, {"family": "Gladyshev", "given": "Vadim N", "initials": "VN"}], "type": "posted-content", "published": "2020-08-07", "journal": {"title": "", "issn": null, "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1101/2020.08.06.20169854", "pmid": null, "labels": {"Category: Genomics & transcriptomics": null, "Type: Preprint": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://www.medrxiv.org/content/10.1101/2020.08.06.20169854v2.supplementary-material", "description": "Supplementary information contains information on publicly available data sources used, instruments used, data on loci associated with risk factors, and genetic correlations between lifespan-related traits and COVID-19"}, {"db": "UK Biobank", "key": "Data used from biobank under Application Number 21988", "description": null}], "notes": [], "created": "2021-06-09T19:33:49.695Z", "modified": "2021-11-18T08:40:25.074Z"}, {"entity": "publication", "iuid": "1c5f8d11e66f46b1828d45f505b2919b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1c5f8d11e66f46b1828d45f505b2919b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1c5f8d11e66f46b1828d45f505b2919b"}}, "title": "Early Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19.", "authors": [{"family": "Alexander", "given": "Jan", "initials": "J"}, {"family": "Tinkov", "given": "Alexey", "initials": "A"}, {"family": "Strand", "given": "Tor A", "initials": "TA"}, {"family": "Alehagen", "given": "Urban", "initials": "U"}, {"family": "Skalny", "given": "Anatoly", "initials": "A"}, {"family": "Aaseth", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2020-08-07", "journal": {"title": "Nutrients", "issn": "2072-6643", "volume": "12", "issue": "8", "issn-l": null}, "abstract": "The novel coronavirus infection (COVID-19) conveys a serious threat globally to health and economy because of a lack of vaccines and specific treatments. A common factor for conditions that predispose for serious progress is a low-grade inflammation, e.g., as seen in metabolic syndrome, diabetes, and heart failure, to which micronutrient deficiencies may contribute. The aim of the present article was to explore the usefulness of early micronutrient intervention, with focus on zinc, selenium, and vitamin D, to relieve escalation of COVID-19.\n\nWe conducted an online search for articles published in the period 2010-2020 on zinc, selenium, and vitamin D, and corona and related virus infections.\n\nThere were a few studies providing direct evidence on associations between zinc, selenium, and vitamin D, and COVID-19. Adequate supply of zinc, selenium, and vitamin D is essential for resistance to other viral infections, immune function, and reduced inflammation. Hence, it is suggested that nutrition intervention securing an adequate status might protect against the novel coronavirus SARS-CoV-2 (Severe Acute Respiratory Syndrome - coronavirus-2) and mitigate the course of COVID-19.\n\nWe recommended initiation of adequate supplementation in high-risk areas and/or soon after the time of suspected infection with SARS-CoV-2. Subjects in high-risk groups should have high priority as regards this nutritive adjuvant therapy, which should be started prior to administration of specific and supportive medical measures.", "doi": "10.3390/nu12082358", "pmid": "32784601", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "nu12082358"}, {"db": "pmc", "key": "PMC7468884"}], "notes": [], "created": "2020-11-30T08:41:02.999Z", "modified": "2020-11-30T08:41:03.023Z"}, {"entity": "publication", "iuid": "c6ecdfad60ee4db38c12af7152621b7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c6ecdfad60ee4db38c12af7152621b7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c6ecdfad60ee4db38c12af7152621b7e"}}, "title": "COVID-19 salivary signature: diagnostic and research opportunities.", "authors": [{"family": "Sapkota", "given": "Dipak", "initials": "D"}, {"family": "S\u00f8land", "given": "Tine Merete", "initials": "TM"}, {"family": "Galtung", "given": "Hilde Kanli", "initials": "HK"}, {"family": "Sand", "given": "Lars Peter", "initials": "LP"}, {"family": "Giannecchini", "given": "Simone", "initials": "S"}, {"family": "To", "given": "Kelvin K W", "initials": "KKW"}, {"family": "Mendes-Correa", "given": "Maria Cassia", "initials": "MC"}, {"family": "Giglio", "given": "Daniel", "initials": "D"}, {"family": "Hass\u00e9us", "given": "Bengt", "initials": "B"}, {"family": "Braz-Silva", "given": "Paulo Henrique", "initials": "PH"}], "type": "journal article", "published": "2020-08-07", "journal": {"title": "J Clin Pathol", "issn": "1472-4146", "volume": null, "issue": null, "issn-l": null}, "abstract": "The COVID-19 (caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)) epidemic started in Wuhan (Hubei Province, China) in mid-December 2019 and quickly spread across the world as a pandemic. As a key to tracing the disease and to implement strategies aimed at breaking the chain of disease transmission, extensive testing for SARS-CoV-2 was suggested. Although nasopharyngeal/oropharyngeal swabs are the most commonly used biological samples for SARS-CoV-2 diagnosis, they have a number of limitations related to sample collection and healthcare personnel safety. In this context, saliva is emerging as a promising alternative to nasopharyngeal/oropharyngeal swabs for COVID-19 diagnosis and monitoring. Saliva collection, being a non-invasive approach with possibility for self-collection, circumvents to a great extent the limitations associated with the use of nasopharyngeal/oropharyngeal swabs. In addition, various salivary biomarkers including the salivary metabolomics offer a high promise to be useful for better understanding of COVID-19 and possibly in the identification of patients with various degrees of severity, including asymptomatic carriers. This review summarises the clinical and scientific basis for the potential use of saliva for COVID-19 diagnosis and disease monitoring. Additionally, we discuss saliva-based biomarkers and their potential clinical and research applications related to COVID-19.", "doi": "10.1136/jclinpath-2020-206834", "pmid": "32769214", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jclinpath-2020-206834"}], "notes": [], "created": "2020-11-30T08:42:54.384Z", "modified": "2020-11-30T08:42:54.407Z"}, {"entity": "publication", "iuid": "25d7fe6e2f794d6297df25b9325629dc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/25d7fe6e2f794d6297df25b9325629dc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/25d7fe6e2f794d6297df25b9325629dc"}}, "title": "COVID-19 and immunological regulations - from basic and translational aspects to clinical implications.", "authors": [{"family": "Sch\u00f6n", "given": "Michael P", "initials": "MP"}, {"family": "Berking", "given": "Carola", "initials": "C"}, {"family": "Biedermann", "given": "Tilo", "initials": "T"}, {"family": "Buhl", "given": "Timo", "initials": "T"}, {"family": "Erpenbeck", "given": "Luise", "initials": "L"}, {"family": "Eyerich", "given": "Kilian", "initials": "K"}, {"family": "Eyerich", "given": "Stefanie", "initials": "S"}, {"family": "Ghoreschi", "given": "Kamran", "initials": "K"}, {"family": "Goebeler", "given": "Matthias", "initials": "M"}, {"family": "Ludwig", "given": "Ralf J", "initials": "RJ"}, {"family": "Sch\u00e4kel", "given": "Knut", "initials": "K"}, {"family": "Schilling", "given": "Bastian", "initials": "B"}, {"family": "Schlapbach", "given": "Christoph", "initials": "C"}, {"family": "Stary", "given": "Georg", "initials": "G"}, {"family": "von Stebut", "given": "Esther", "initials": "E"}, {"family": "Steinbrink", "given": "Kerstin", "initials": "K"}], "type": "journal article", "published": "2020-08-06", "journal": {"title": "J Dtsch Dermatol Ges", "issn": "1610-0387", "volume": null, "issue": null, "issn-l": "1610-0379"}, "abstract": "The COVID-19 pandemic caused by SARS-CoV-2 has far-reaching direct and indirect medical consequences. These include both the course and treatment of diseases. It is becoming increasingly clear that infections with SARS-CoV-2 can cause considerable immunological alterations, which particularly also affect pathogenetically and/or therapeutically relevant factors. Against this background we summarize here the current state of knowledge on the interaction of SARS-CoV-2/COVID-19 with mediators of the acute phase of inflammation (TNF, IL-1, IL-6), type 1 and type 17 immune responses (IL-12, IL-23, IL-17, IL-36), type 2 immune reactions (IL-4, IL-13, IL-5, IL-31, IgE), B-cell immunity, checkpoint regulators (PD-1, PD-L1, CTLA4), and orally druggable signaling pathways (JAK, PDE4, calcineurin). In addition, we discuss in this context non-specific immune modulation by glucocorticosteroids, methotrexate, antimalarial drugs, azathioprine, dapsone, mycophenolate mofetil and fumaric acid esters, as well as neutrophil granulocyte-mediated innate immune mechanisms. From these recent findings we derive possible implications for the therapeutic modulation of said immunological mechanisms in connection with SARS-CoV-2/COVID-19. Although, of course, the greatest care should be taken with patients with immunologically mediated diseases or immunomodulating therapies, it appears that many treatments can also be carried out during the COVID-19 pandemic; some even appear to alleviate COVID-19.", "doi": "10.1111/ddg.14169", "pmid": "32761894", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7436872"}], "notes": [], "created": "2020-11-26T12:16:43.799Z", "modified": "2020-11-30T08:42:56.759Z"}, {"entity": "publication", "iuid": "36ec715ded154e0d82da66e25352c506", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/36ec715ded154e0d82da66e25352c506.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/36ec715ded154e0d82da66e25352c506"}}, "title": "International variation in the management of severe COVID-19 patients.", "authors": [{"family": "Azoulay", "given": "Elie", "initials": "E"}, {"family": "de Waele", "given": "Jan", "initials": "J"}, {"family": "Ferrer", "given": "Ricard", "initials": "R"}, {"family": "Staudinger", "given": "Thomas", "initials": "T"}, {"family": "Borkowska", "given": "Marta", "initials": "M"}, {"family": "Povoa", "given": "Pedro", "initials": "P"}, {"family": "Iliopoulou", "given": "Katerina", "initials": "K"}, {"family": "Artigas", "given": "Antonio", "initials": "A"}, {"family": "Schaller", "given": "Stefan J", "initials": "SJ"}, {"family": "Shankar-Hari", "given": "Manu", "initials": "M"}, {"family": "Pellegrini", "given": "Mariangela", "initials": "M"}, {"family": "Darmon", "given": "Michael", "initials": "M"}, {"family": "Kesecioglu", "given": "Jozef", "initials": "J"}, {"family": "Cecconi", "given": "Maurizio", "initials": "M"}], "type": "journal article", "published": "2020-08-05", "journal": {"title": "Crit Care", "issn": "1466-609X", "volume": "24", "issue": "1", "pages": "486", "issn-l": "1364-8535"}, "abstract": "There is little evidence to support the management of severe COVID-19 patients.\n\nTo document this variation in practices, we performed an online survey (April 30-May 25, 2020) on behalf of the European Society of Intensive Care Medicine (ESICM). A case vignette was sent to ESICM members. Questions investigated practices for a previously healthy 39-year-old patient presenting with severe hypoxemia from COVID-19 infection.\n\nA total of 1132 ICU specialists (response rate 20%) from 85 countries (12 regions) responded to the survey. The survey provides information on the heterogeneity in patient's management, more particularly regarding the timing of ICU admission, the first line oxygenation strategy, optimization of management, and ventilatory settings in case of refractory hypoxemia. Practices related to antibacterial, antiviral, and anti-inflammatory therapies are also investigated.\n\nThere are important practice variations in the management of severe COVID-19 patients, including differences at regional and individual levels. Large outcome studies based on multinational registries are warranted.", "doi": "10.1186/s13054-020-03194-w", "pmid": "32758266", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-020-03194-w"}, {"db": "pmc", "key": "PMC7403819"}], "notes": [], "created": "2020-12-07T15:44:14.482Z", "modified": "2021-02-26T08:45:48.038Z"}, {"entity": "publication", "iuid": "37c9a6ce93fa4bbba28a966ae11c4157", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/37c9a6ce93fa4bbba28a966ae11c4157.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/37c9a6ce93fa4bbba28a966ae11c4157"}}, "title": "High seroprevalence of SARS-CoV-2 in elderly care employees in Sweden.", "authors": [{"family": "Lindahl", "given": "Johanna F", "initials": "JF"}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Esmaeilzadeh", "given": "Mouna", "initials": "M"}, {"family": "Olsen", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Winter", "given": "Reidar", "initials": "R"}, {"family": "Amer", "given": "Stefan", "initials": "S"}, {"family": "Moln\u00e1r", "given": "Christian", "initials": "C"}, {"family": "Svalberg", "given": "Ann", "initials": "A"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "journal article", "published": "2020-08-05", "journal": {"title": "Infect Ecol Epidemiol", "issn": "2000-8686", "issn-l": "2000-8686", "volume": "10", "issue": "1", "pages": "1789036"}, "abstract": "The COVID-19 pandemic is growing and spread in the Swedish elderly care system during April 2020. The increasing number of employees on sick-leave due to COVID-19 created severe logistic problems. Some elderly care homes therefore started to screen their personnel to secure the safety of the elderly and to avoid unnecessary quarantine of potentially immune employees. Secondary data from a screening with a COVID-19 rapid test for detection of SARS-CoV-2-specific IgM and IgG of 1,005 employees in 22 elderly care homes in Stockholm, Sweden, were analyzed. Seropositive employees were found in 21 out of the 22 care homes. In total, 23% (231/1,005) of the employees tested positive for antibodies against SARS-CoV-2, and 14.3% (144/1,005) were found positive for IgM (either alone or combined with IgG), indicating recent or present infection. Of those that tested seropositive, 46.5% did not report any clinical symptoms, indicating pre- or asymptomatic infections. Reported symptoms with the highest correlation with seropositivity were fever and loss of smell and taste. These results suggest that antibody testing of employees in elderly care homes is valuable for surveillance of disease development and a crucial screening tool in the effort to decrease the death toll in this pandemic.", "doi": "10.1080/20008686.2020.1789036", "pmid": "32939231", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Serology": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.1080/20008686.2020.1789036", "description": "Serological responses of 1,005 employees to SARS-CoV-2 at 22 different elderly care homes in Stockholm"}], "notes": [], "created": "2020-10-30T11:59:27.014Z", "modified": "2021-02-26T08:46:49.351Z"}, {"entity": "publication", "iuid": "e0b776a8100d4f16ba4500c1a3f97b17", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e0b776a8100d4f16ba4500c1a3f97b17.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e0b776a8100d4f16ba4500c1a3f97b17"}}, "title": "Does COVID-19 teach us anything for our future?", "authors": [{"family": "Ralph Edwards", "given": "Ivor", "initials": "I"}, {"family": "Lindquist", "given": "Marie", "initials": "M"}], "type": "editorial", "published": "2020-08-04", "journal": {"title": "Int J Risk Saf Med", "issn": "1878-6847", "volume": "31", "issue": "3", "pages": "107-109", "issn-l": null}, "abstract": null, "doi": "10.3233/JRS-201006", "pmid": "32741780", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "JRS201006"}], "notes": [], "created": "2020-12-07T16:04:51.880Z", "modified": "2020-12-07T16:04:51.890Z"}, {"entity": "publication", "iuid": "53523ecc594e44228bfa5d7a00454b93", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53523ecc594e44228bfa5d7a00454b93.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53523ecc594e44228bfa5d7a00454b93"}}, "title": "Charting a \"Green Path\" for Recovery from COVID-19.", "authors": [{"family": "Mukanjari", "given": "Samson", "initials": "S"}, {"family": "Sterner", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2020-08-04", "journal": {"title": "Environ Resour Econ (Dordr)", "issn": "0924-6460", "volume": null, "issue": null, "pages": "1-29", "issn-l": null}, "abstract": "Should the economic recovery from the 2019 novel coronavirus disease (COVID-19) be green? The current crisis is so severe that we should not take the answer for granted. It requires serious thought and we start by reviewing some arguments for and against a green approach. A crucial element is of course to see how different industries fare in the current crisis. Our empirical contribution is to examine daily stock returns for firms from the STOXX Europe 600 index. We find that firms with higher carbon intensities experienced significantly large decreases in stock values particularly those within the crude petroleum extraction, air transport and coke and refined petroleum industries. Our tentative conclusion is that efforts to revitalize the economy should avoid subsidizing stranded assets and instead target the industries of the future. However, identifying these will not necessarily be easy. We find, for example, that having an official ESG \"climate change policy\" has no effect on firm performance during the pandemic. We suggest possible ways of designing a new form of more informative index.", "doi": "10.1007/s10640-020-00479-0", "pmid": "32836858", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "479"}, {"db": "pmc", "key": "PMC7399619"}], "notes": [], "created": "2020-12-07T10:38:46.542Z", "modified": "2020-12-07T10:38:46.565Z"}, {"entity": "publication", "iuid": "a218165be69a45edb93660bd7b6cfe16", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a218165be69a45edb93660bd7b6cfe16.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a218165be69a45edb93660bd7b6cfe16"}}, "title": "Autoimmune Encephalitis Presenting with Acute Excited Catatonia in a 40-Year-Old Male Patient with Covid-19", "authors": [{"family": "Mulder", "given": "Jan", "initials": "J"}, {"family": "Feresiadou", "given": "Amalia", "initials": "A"}, {"family": "Fallmar", "given": "David", "initials": "D"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "Rasmusson", "given": "Annica", "initials": "A"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Cunningham", "given": "Janet Lynn", "initials": "JL"}], "type": "posted-content", "published": "2020-08-04", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.07.23.20160770", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-08T07:05:15.963Z", "modified": "2021-02-26T08:45:48.537Z"}, {"entity": "publication", "iuid": "fb5f4bebc9124a8794bd30fa72135cff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb5f4bebc9124a8794bd30fa72135cff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb5f4bebc9124a8794bd30fa72135cff"}}, "title": "Tocilizumab shortens time on mechanical ventilation and length of hospital stay in patients with severe COVID-19: a retrospective cohort study.", "authors": [{"family": "Eimer", "given": "J", "initials": "J"}, {"family": "Vesterbacka", "given": "J", "initials": "J"}, {"family": "Svensson", "given": "A-K", "initials": "A"}, {"family": "Stojanovic", "given": "B", "initials": "B"}, {"family": "Wagrell", "given": "C", "initials": "C"}, {"family": "S\u00f6nnerborg", "given": "A", "initials": "A"}, {"family": "Nowak", "given": "P", "initials": "P"}], "type": "letter", "published": "2020-08-03", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1111/joim.13162", "pmid": "32744399", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7436415"}], "notes": [], "created": "2020-12-04T08:37:40.803Z", "modified": "2021-02-26T08:45:03.368Z"}, {"entity": "publication", "iuid": "bc6e19c1df8142dfaa90075bd10b585e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bc6e19c1df8142dfaa90075bd10b585e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bc6e19c1df8142dfaa90075bd10b585e"}}, "title": "Misleading media coverage of Sweden's response to covid-19.", "authors": [{"family": "Irwin", "given": "Rachel E", "initials": "RE"}], "type": "letter", "published": "2020-08-03", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "370", "issue": null, "pages": "m3031", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m3031", "pmid": "32747388", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-07T16:00:57.583Z", "modified": "2023-01-13T13:50:00.714Z"}, {"entity": "publication", "iuid": "62f5193eb1274e2598aa5bb32f854c43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/62f5193eb1274e2598aa5bb32f854c43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/62f5193eb1274e2598aa5bb32f854c43"}}, "title": "Social determinants of health and inequalities in COVID-19.", "authors": [{"family": "Burstr\u00f6m", "given": "Bo", "initials": "B"}, {"family": "Tao", "given": "Wenjing", "initials": "W"}], "type": "journal article", "published": "2020-08-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": "30", "issue": "4", "pages": "617-618"}, "abstract": null, "doi": "10.1093/eurpub/ckaa095", "pmid": "32638998", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5868718"}, {"db": "pmc", "key": "PMC7454505"}], "notes": [], "created": "2020-12-04T08:34:26.857Z", "modified": "2021-01-25T10:28:30.704Z"}, {"entity": "publication", "iuid": "cc1abb039bfa44da943ee142c71545d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc1abb039bfa44da943ee142c71545d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc1abb039bfa44da943ee142c71545d0"}}, "title": "\ufeffEASAPS/ESPRAS Considerations in getting back to work in Plastic Surgery with the COVID-19 Pandemic - A European point of view.", "authors": [{"family": "van Heijningen", "given": "Ivar", "initials": "I"}, {"family": "Frank", "given": "Konstantin", "initials": "K"}, {"family": "Almeida", "given": "Francisco", "initials": "F"}, {"family": "B\u00f6sch", "given": "Urs", "initials": "U"}, {"family": "Bradic", "given": "Nicola", "initials": "N"}, {"family": "Costa", "given": "Horacio", "initials": "H"}, {"family": "Demirdover", "given": "Cenk", "initials": "C"}, {"family": "Henley", "given": "Mark", "initials": "M"}, {"family": "Kamolz", "given": "Lars Peter", "initials": "LP"}, {"family": "Rouif", "given": "Michel", "initials": "M"}, {"family": "Spendel", "given": "Stephan", "initials": "S"}, {"family": "Russe-Wilflingseder", "given": "Katharina", "initials": "K"}, {"family": "Stark", "given": "Birgit", "initials": "B"}, {"family": "Giunta", "given": "Riccardo E", "initials": "RE"}, {"family": "Parreira", "given": "Jose Carlos", "initials": "JC"}, {"family": "Zic", "given": "Rado", "initials": "R"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Handchir Mikrochir Plast Chir", "issn": "1439-3980", "volume": "52", "issue": "4", "pages": "257-264", "issn-l": "0722-1819"}, "abstract": "The aim of this paper is to summarize the results of a consensus process and a European webinar of the two societies, European Association of Societies of Aesthetic Surgery (EASAPS) and the European Society of Plastic, Reconstructive and Aesthetic Societies (ESPRAS) on what is considered safe practice based on the scientific knowledge we have today. This review of the current situations gives considerations which have to be taken into account when getting back to work in plastic surgery with COVID-19 in Europe. At all times, one should be familiar the local and regional infection rates in the community, with particular emphasis on the emergence of second and third waves of the pandemic. Due to the fast-evolving nature of the COVID-19 pandemic the recommendations aim to be rather considerations than fixed guidelines and might need to be revised in near future.", "doi": "10.1055/a-1175-4169", "pmid": "32422664", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-25T08:30:59.859Z", "modified": "2020-11-30T09:07:53.328Z"}, {"entity": "publication", "iuid": "0d301750f52348f487fee1959c1b870b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d301750f52348f487fee1959c1b870b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d301750f52348f487fee1959c1b870b"}}, "title": "Vascular Surgery in Unreal Times.", "authors": [{"family": "Eilenberg", "given": "Wolf", "initials": "W"}, {"family": "Busch", "given": "Albert", "initials": "A"}, {"family": "Wagenh\u00e4user", "given": "Markus", "initials": "M"}, {"family": "Giannoukas", "given": "Athanasios", "initials": "A"}, {"family": "Wanhainen", "given": "Anders", "initials": "A"}, {"family": "Neumayer", "given": "Christoph", "initials": "C"}, {"family": "Haulon", "given": "Stephan", "initials": "S"}], "type": "editorial", "published": "2020-08-00", "journal": {"title": "Eur J Vasc Endovasc Surg", "issn": "1532-2165", "volume": "60", "issue": "2", "pages": "167-168", "issn-l": "1078-5884"}, "abstract": "Editorial", "doi": "10.1016/j.ejvs.2020.05.031", "pmid": "32605851", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1078-5884(20)30453-6"}, {"db": "pmc", "key": "PMC7320915"}], "notes": [], "created": "2020-11-22T09:36:23.824Z", "modified": "2020-12-08T15:23:07.202Z"}, {"entity": "publication", "iuid": "6ac885a2ae224f9b8751ef2a27f87f3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ac885a2ae224f9b8751ef2a27f87f3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ac885a2ae224f9b8751ef2a27f87f3d"}}, "title": "Using the prone position could help to combat the development of fast hypoxia in some patients with COVID-19.", "authors": [{"family": "Lindahl", "given": "Sten G E", "initials": "SGE"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "volume": "109", "issue": "8", "pages": "1539-1544", "issn-l": null}, "abstract": "The world is facing an explosive COVID-19 pandemic. Some cases rapidly develop deteriorating lung function, which causes deep hypoxaemia and requires urgent treatment. Many centres have started treating patients in the prone position, and oxygenation has improved considerably in some cases. Questions have been raised regarding the mechanisms behind this. The mini review provides some insights into the role of supine and prone body positions and summarises the latest understanding of the responsible mechanisms. The scope for discussion is outside the neonatal period and entirely based on experimental and clinical experiences related to adults. The human respiratory system is a complex interplay of many different variables. Therefore, this mini review has prioritised previous and ongoing research to find explanations based on three scientific areas: gravity, lung structure and fractal geometry and vascular regulation. It concludes that gravity is one of the variables responsible for ventilation/perfusion matching but in concert with lung structure and fractal geometry, ventilation and regulation of lung vascular tone. Since ventilation distribution does not change between supine and prone positions, the higher expression of nitric oxide in dorsal lung vessels than in ventral vessels is likely to be the most important mechanism behind enhanced oxygenation in the prone position.", "doi": "10.1111/apa.15382", "pmid": "32484966", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7301016"}], "notes": [], "created": "2020-11-25T08:08:41.192Z", "modified": "2020-11-30T09:02:31.821Z"}, {"entity": "publication", "iuid": "27bae21f98f64e098fe22a4be2b9d608", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27bae21f98f64e098fe22a4be2b9d608.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27bae21f98f64e098fe22a4be2b9d608"}}, "title": "Updated rapid risk assessment from ECDC on coronavirus disease (COVID-19) pandemic in the EU/EEA and the UK: resurgence of cases.", "authors": [{"family": "Eurosurveillance editorial team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "32", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.32.2008131", "pmid": "32794445", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7427298"}], "notes": [], "created": "2020-12-07T13:22:35.411Z", "modified": "2020-12-07T13:22:35.421Z"}, {"entity": "publication", "iuid": "b9c70b65997f4554a82535ca0072b2b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9c70b65997f4554a82535ca0072b2b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9c70b65997f4554a82535ca0072b2b9"}}, "title": "The COVID-19 pandemic and the Swedish strategy: Epidemiology and postmodernism.", "authors": [{"family": "Lindstr\u00f6m", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "SSM Popul Health", "issn": "2352-8273", "volume": "11", "issue": null, "pages": "100643", "issn-l": null}, "abstract": "The aim is to outline the underlying epidemiological thinking and mentality in post-materialist and postmodern Sweden behind the Swedish strategy. The aim is not to investigate the handling of the pandemic in Sweden in the long-run. Overconfidence in herd immunity, overconfidence in individual responsibility in a pandemic needing community-centered approaches, overconfidence in evidence-based medicine and neglect to coordinate with the WHO and other countries may be associated with post-materialist values and postmodernism including opposition against modern authority, rationality and science, and also an anti-traditionalist stance towards older generations. COVID-19 epidemiology and postmodernism may be a dangerous combination.", "doi": "10.1016/j.ssmph.2020.100643", "pmid": "32885019", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2352-8273(20)30280-9"}, {"db": "pii", "key": "100643"}, {"db": "pmc", "key": "PMC7453138"}], "notes": [], "created": "2020-12-06T07:29:56.517Z", "modified": "2020-12-06T07:29:56.540Z"}, {"entity": "publication", "iuid": "77dbed03c6fc462eb917dc197ce883ea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/77dbed03c6fc462eb917dc197ce883ea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/77dbed03c6fc462eb917dc197ce883ea"}}, "title": "Steroid-Responsive Encephalitis in Coronavirus Disease 2019.", "authors": [{"family": "Pilotto", "given": "Andrea", "initials": "A"}, {"family": "Odolini", "given": "Silvia", "initials": "S"}, {"family": "Masciocchi", "given": "Stefano", "initials": "S"}, {"family": "Comelli", "given": "Agnese", "initials": "A"}, {"family": "Volonghi", "given": "Irene", "initials": "I"}, {"family": "Gazzina", "given": "Stefano", "initials": "S"}, {"family": "Nocivelli", "given": "Sara", "initials": "S"}, {"family": "Pezzini", "given": "Alessandro", "initials": "A"}, {"family": "Foc\u00e0", "given": "Emanuele", "initials": "E"}, {"family": "Caruso", "given": "Arnaldo", "initials": "A"}, {"family": "Leonardi", "given": "Matilde", "initials": "M"}, {"family": "Pasolini", "given": "Maria P", "initials": "MP"}, {"family": "Gasparotti", "given": "Roberto", "initials": "R"}, {"family": "Castelli", "given": "Francesco", "initials": "F"}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Padovani", "given": "Alessandro", "initials": "A"}], "type": "case reports", "published": "2020-08-00", "journal": {"title": "Ann Neurol", "issn": "1531-8249", "volume": "88", "issue": "2", "pages": "423-427", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) infection has the potential for targeting the central nervous system, and several neurological symptoms have been described in patients with severe respiratory distress. Here, we described the case of a 60-year-old patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection but only mild respiratory abnormalities who developed an akinetic mutism attributable to encephalitis. Magnetic resonance imaging was negative, whereas electroencephalography showed generalized theta slowing. Cerebrospinal fluid analyses during the acute stage were negative for SARS-CoV-2, positive for pleocytosis and hyperproteinorrachia, and showed increased interleukin-8 and tumor necrosis factor-\u03b1 concentrations. Other infectious or autoimmune disorders were excluded. A progressive clinical improvement along with a reduction of cerebrospinal fluid parameters was observed after high-dose steroid treatment, thus arguing for an inflammatory-mediated brain involvement related to COVID-19. ANN NEUROL 2020;88:423-427.", "doi": "10.1002/ana.25783", "pmid": "32418288", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7276848"}], "notes": [], "created": "2020-12-10T08:55:43.469Z", "modified": "2021-02-26T08:45:48.330Z"}, {"entity": "publication", "iuid": "2dec25cb865b4377aafe550af4a49d56", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2dec25cb865b4377aafe550af4a49d56.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2dec25cb865b4377aafe550af4a49d56"}}, "title": "Sports Health During the SARS-Cov-2 Pandemic.", "authors": [{"family": "Timpka", "given": "Toomas", "initials": "T"}], "type": "letter", "published": "2020-08-00", "journal": {"title": "Sports Med", "issn": "1179-2035", "volume": "50", "issue": "8", "pages": "1413-1416", "issn-l": null}, "abstract": null, "doi": "10.1007/s40279-020-01288-7", "pmid": "32361898", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40279-020-01288-7"}, {"db": "pmc", "key": "PMC7195617"}], "notes": [], "created": "2020-12-10T07:24:46.451Z", "modified": "2020-12-10T07:24:46.473Z"}, {"entity": "publication", "iuid": "e2b2172a254943d9818aa55345a77951", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2b2172a254943d9818aa55345a77951.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2b2172a254943d9818aa55345a77951"}}, "title": "Society of Robotic Surgery review: recommendations regarding the risk of COVID-19 transmission during minimally invasive surgery.", "authors": [{"family": "Porter", "given": "James", "initials": "J"}, {"family": "Blau", "given": "Elliot", "initials": "E"}, {"family": "Gharagozloo", "given": "Farid", "initials": "F"}, {"family": "Martino", "given": "Martin", "initials": "M"}, {"family": "Cerfolio", "given": "Robert", "initials": "R"}, {"family": "Duvvuri", "given": "Umamaheswar", "initials": "U"}, {"family": "Caceres", "given": "Aileen", "initials": "A"}, {"family": "Badani", "given": "Ketan", "initials": "K"}, {"family": "Bhayani", "given": "Sam", "initials": "S"}, {"family": "Collins", "given": "Justin", "initials": "J"}, {"family": "Coelho", "given": "Rafael", "initials": "R"}, {"family": "Rocco", "given": "Bernard", "initials": "B"}, {"family": "Wiklund", "given": "Peter", "initials": "P"}, {"family": "Nathan", "given": "Senthil", "initials": "S"}, {"family": "Parra-Davila", "given": "Eduardo", "initials": "E"}, {"family": "Ortiz-Ortiz", "given": "Carlos", "initials": "C"}, {"family": "Maes", "given": "Kris", "initials": "K"}, {"family": "Dasgupta", "given": "Prokar", "initials": "P"}, {"family": "Patel", "given": "Vipul", "initials": "V"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "BJU Int", "issn": "1464-410X", "volume": "126", "issue": "2", "pages": "225-234", "issn-l": "1464-4096"}, "abstract": "To determine the risk of COVID-19 transmission during minimally invasive surgical (MIS) procedures METHODS: Surgical society statements regarding the risk of COVID transmission during MIS procedures were reviewed. In addition, the available literature on COVID-19 and other viral transmission in CO2 pneumoperitoneum, as well as the presence of virus in the plume created by electrocautery during MIS was reviewed. The society recommendations were compared to the available literature on the topic to create our review and recommendations to mitigate COVID-19 transmission.\n\nThe recommendations promulgated by various surgical societies evolved over time as more information became available on COVID-19 transmission. Review of the available literature on the presence of COVID-19 in CO2 pneumoperitoneum was inconclusive. There is no clear evidence of the presence of COVID-19 in plume created by electrocautery. Technologies to reduce CO2 pneumoperitoneum release into the operating room as well as filter viral particles are available and should reduce the exposure risk to operating room personnel.\n\nThere is no clear evidence of COVID-19 virus in the CO2 used during MIS procedures or in the plume created by electrocautery. Until the presence or absence of COVID-19 viral particles has been clearly established, measures to mitigate CO2 and surgical cautery plume release into the operating room should be performed. Further study on the presence of COVID-19 in MIS pneumoperitoneum and cautery plume is needed.", "doi": "10.1111/bju.15105", "pmid": "32383520", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7267386"}], "notes": [], "created": "2020-11-25T07:32:27.293Z", "modified": "2020-12-10T07:40:38.266Z"}, {"entity": "publication", "iuid": "805eae795adb4cc5a630baf15dde1a2e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/805eae795adb4cc5a630baf15dde1a2e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/805eae795adb4cc5a630baf15dde1a2e"}}, "title": "Smell and taste alterations in COVID-19: a cross-sectional analysis of different cohorts.", "authors": [{"family": "Paderno", "given": "Alberto", "initials": "A"}, {"family": "Schreiber", "given": "Alberto", "initials": "A"}, {"family": "Grammatica", "given": "Alberto", "initials": "A"}, {"family": "Raffetti", "given": "Elena", "initials": "E"}, {"family": "Tomasoni", "given": "Michele", "initials": "M"}, {"family": "Gualtieri", "given": "Tommaso", "initials": "T"}, {"family": "Taboni", "given": "Stefano", "initials": "S"}, {"family": "Zorzi", "given": "Silvia", "initials": "S"}, {"family": "Lombardi", "given": "Davide", "initials": "D"}, {"family": "Deganello", "given": "Alberto", "initials": "A"}, {"family": "Redaelli De Zinis", "given": "Luca Oscar", "initials": "LO"}, {"family": "Maroldi", "given": "Roberto", "initials": "R"}, {"family": "Mattavelli", "given": "Davide", "initials": "D"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Int Forum Allergy Rhinol", "issn": "2042-6984", "volume": "10", "issue": "8", "pages": "955-962", "issn-l": "2042-6976"}, "abstract": "Olfactory (OD) and gustatory (GD) dysfunction have been proven to be a typical symptom of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. However, their prevalence in different patient populations still needs to be clarified.\n\nA cross-sectional study was performed from March 27 to April 1, 2020, in Northern Italy. Physicians administered a survey-based questionnaire to SARS-CoV-2-positive patients with the aim of assessing symptoms, focusing on OD and GD. Two groups were studied: group A, patients hospitalized at Azianda Socio Sanitaria Territoriale (ASST) Spedali Civili University Hospital of Brescia; and group B, home-quarantined subjects.\n\nA total of 508 patients were enrolled: 295 in group A and 213 in group B. Mean age \u00b1 standard deviation (SD) was 55 \u00b1 15 years; 56% were men. Overall, OD and GD were present in 56% (95% confidence interval [CI], 51% to 60%) and 63% (95% CI, 59% to 67%) of cases, respectively. In group A, the prevalence of OD and GD was 44% (95% CI, 38% to 50%) and 52% (95% CI, 46% to 58%), respectively. In group B, the prevalence of OD and GD was 72% (95% CI, 65% to 79%) and 79% (95% CI, 73% to 84%), respectively. In the entire cohort, total loss of olfaction and taste was reported in 64% and 60% of cases, respectively. OD and GD occurred as the first symptom in 10% and 11% of cases, respectively; in the remaining cases, they occurred after a mean of 4 \u00b1 3 days following the first symptom. At the time of the questionnaire, complete resolution of OD and GD was reported in 52% and 55% of cases, respectively (mean duration, 9 \u00b1 5 days in both).\n\nOD and GD are more prevalent in home-quarantined subjects, and they are independently associated with younger age and female gender.", "doi": "10.1002/alr.22610", "pmid": "32410386", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7272886"}], "notes": [], "created": "2020-11-25T08:09:58.321Z", "modified": "2021-02-26T08:45:48.417Z"}, {"entity": "publication", "iuid": "e58494e9496644f8818bce57e34e8fc9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e58494e9496644f8818bce57e34e8fc9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e58494e9496644f8818bce57e34e8fc9"}}, "title": "School and pre-school children with type 1 diabetes during Covid-19 quarantine: The synergic effect of parental care and technology.", "authors": [{"family": "Schiaffini", "given": "Riccardo", "initials": "R"}, {"family": "Barbetti", "given": "Fabrizio", "initials": "F"}, {"family": "Rapini", "given": "Novella", "initials": "N"}, {"family": "Inzaghi", "given": "Elena", "initials": "E"}, {"family": "Deodati", "given": "Annalisa", "initials": "A"}, {"family": "Patera", "given": "Ippolita P", "initials": "IP"}, {"family": "Matteoli", "given": "Maria C", "initials": "MC"}, {"family": "Ciampalini", "given": "Paolo", "initials": "P"}, {"family": "Carducci", "given": "Chiara", "initials": "C"}, {"family": "Lorubbio", "given": "Antonella", "initials": "A"}, {"family": "Schiaffini", "given": "Gabriele", "initials": "G"}, {"family": "Cianfarani", "given": "Stefano", "initials": "S"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Diabetes Res Clin Pract", "issn": "1872-8227", "issn-l": null, "volume": "166", "issue": null, "pages": "108302"}, "abstract": "Management of Type 1 Diabetes (T1D) poses numerous challenges, especially for young children and their families. Parental care positively influencesthe outcomesofchildren with T1D, while there are often criticisms in school environment. The COVID-19 pandemic has forced children and parents to spend many hours at home and diabetes care has returned mainly in the hands of parents.\r\n\r\nTo evaluate the effectiveness of exclusive return to parental care in pre-school and school children with T1D treated with Tandem Basal IQ system during the COVID-19 pandemic.\r\n\r\n22 children (M:F = 14:8) with T1D have been evaluated. We compared insulin and CGM data (TIR, TBR and TAR) of two periods: PRE-COV and IN-COV, in which children have transitioned from normal school attendance to the exclusive care of their parents.\r\n\r\nDuring the IN-COV period a significantly (p < 0.001) higher median value of TIR (66,41%) was observed as compared to PRE-COV period (61,45%). Patients also showed a statistically significant difference (p < 0.002) between the IN-COV period and the PRE-COV period as concerning the TAR metric: respectively 29,86 \u00b1 10,6% vs 34,73 \u00b1 12,8%. The difference between the bolus insulin doses was statistically significant (PRE-COV 5,3 IU/day, IN-COV 7,9 IU/day - p < 0.05).\r\n\r\nOur observational real-life study confirms the positive effect of parental care in T1D very young children and demonstrates that during the COVID-19 pandemic it was possible to obtain a good glycometabolic compensation despite the significant change in lifestyle.", "doi": "10.1016/j.diabres.2020.108302", "pmid": "32623034", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0168-8227(20)30554-4"}, {"db": "pmc", "key": "PMC7332425"}], "notes": [], "created": "2020-12-08T15:04:58.822Z", "modified": "2022-11-10T07:12:20.042Z"}, {"entity": "publication", "iuid": "dafcf340284d46f384c44facaf351f9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dafcf340284d46f384c44facaf351f9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dafcf340284d46f384c44facaf351f9c"}}, "title": "Perceived Worsening of Tics in Adult Patients with Tourette Syndrome after the COVID-19 Outbreak.", "authors": [{"family": "Mataix-Cols", "given": "David", "initials": "D"}, {"family": "Ringberg", "given": "Helene", "initials": "H"}, {"family": "Fern\u00e1ndez de la Cruz", "given": "Lorena", "initials": "L"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Mov Disord Clin Pract", "issn": "2330-1619", "volume": "7", "issue": "6", "pages": "725-726", "issn-l": null}, "abstract": null, "doi": "10.1002/mdc3.13004", "pmid": "32775530", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "MDC313004"}, {"db": "pmc", "key": "PMC7323109"}], "notes": [], "created": "2020-12-07T13:33:12.659Z", "modified": "2021-02-26T08:45:48.786Z"}, {"entity": "publication", "iuid": "42aaa70ea4114cfc9360097b297d92df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/42aaa70ea4114cfc9360097b297d92df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/42aaa70ea4114cfc9360097b297d92df"}}, "title": "Palliative care: Essential support for patients with heart failure in the COVID-19 pandemic.", "authors": [{"family": "Hill", "given": "Loreena", "initials": "L"}, {"family": "Beattie", "given": "James M", "initials": "JM"}, {"family": "Geller", "given": "Tal Prager", "initials": "TP"}, {"family": "Baruah", "given": "Resham", "initials": "R"}, {"family": "Boyne", "given": "Josiane", "initials": "J"}, {"family": "Stolfo", "given": "Giuseppe Di", "initials": "GD"}, {"family": "Jaarsma", "given": "Tiny", "initials": "T"}], "type": "editorial", "published": "2020-08-00", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "volume": "19", "issue": "6", "pages": "469-472", "issn-l": null}, "abstract": null, "doi": "10.1177/1474515120932814", "pmid": "32515212", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-09T10:31:28.295Z", "modified": "2020-12-09T10:31:28.305Z"}, {"entity": "publication", "iuid": "7011be2092af4e399c629f8276b9f270", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7011be2092af4e399c629f8276b9f270.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7011be2092af4e399c629f8276b9f270"}}, "title": "Optimizing safety surveillance for COVID-19 vaccines.", "authors": [{"family": "Chandler", "given": "Rebecca E", "initials": "RE"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Nat Rev Immunol", "issn": "1474-1741", "volume": "20", "issue": "8", "pages": "451-452", "issn-l": "1474-1733"}, "abstract": null, "doi": "10.1038/s41577-020-0372-8", "pmid": "32555401", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41577-020-0372-8"}, {"db": "pmc", "key": "PMC7298922"}], "notes": [], "created": "2020-11-22T08:40:40.615Z", "modified": "2020-11-30T08:59:20.299Z"}, {"entity": "publication", "iuid": "d5444d00b5ee4c079ee7c5d8184eb62c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5444d00b5ee4c079ee7c5d8184eb62c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5444d00b5ee4c079ee7c5d8184eb62c"}}, "title": "On the interactions of the receptor-binding domain of SARS-CoV-1 and SARS-CoV-2 spike proteins with monoclonal antibodies and the receptor ACE2.", "authors": [{"family": "Corr\u00eaa Giron", "given": "Carolina", "initials": "C"}, {"family": "Laaksonen", "given": "Aatto", "initials": "A"}, {"family": "Barroso da Silva", "given": "Fernando L", "initials": "FL"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Virus Res", "issn": "1872-7492", "volume": "285", "issue": null, "pages": "198021", "issn-l": null}, "abstract": "A new betacoronavirus named SARS-CoV-2 has emerged as a new threat to global health and economy. A promising target for both diagnosis and therapeutics treatments of the new disease named COVID-19 is the coronavirus (CoV) spike (S) glycoprotein. By constant-pH Monte Carlo simulations and the PROCEEDpKa method, we have mapped the electrostatic epitopes for four monoclonal antibodies and the angiotensin-converting enzyme 2 (ACE2) on both SARS-CoV-1 and the new SARS-CoV-2 S receptor binding domain (RBD) proteins. We also calculated free energy of interactions and shown that the S RBD proteins from both SARS viruses binds to ACE2 with similar affinities. However, the affinity between the S RBD protein from the new SARS-CoV-2 and ACE2 is higher than for any studied antibody previously found complexed with SARS-CoV-1. Based on physical chemical analysis and free energies estimates, we can shed some light on the involved molecular recognition processes, their clinical aspects, the implications for drug developments, and suggest structural modifications on the CR3022 antibody that would improve its binding affinities for SARS-CoV-2 and contribute to address the ongoing international health crisis.", "doi": "10.1016/j.virusres.2020.198021", "pmid": "32416259", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Proteins": null}, "xrefs": [{"db": "pii", "key": "S0168-1702(20)30352-X"}, {"db": "pmc", "key": "PMC7228703"}], "notes": [], "created": "2020-12-10T08:53:57.256Z", "modified": "2021-02-26T08:47:18.863Z"}, {"entity": "publication", "iuid": "465be802f0f04f968d6d9ab340e63bb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/465be802f0f04f968d6d9ab340e63bb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/465be802f0f04f968d6d9ab340e63bb1"}}, "title": "Management strategies for children with COVID-19: ESPR practical recommendations.", "authors": [{"family": "Raissaki", "given": "Maria", "initials": "M"}, {"family": "Shelmerdine", "given": "Susan C", "initials": "SC"}, {"family": "Damasio", "given": "Maria Beatrice", "initials": "MB"}, {"family": "Toso", "given": "Seema", "initials": "S"}, {"family": "Kvist", "given": "Ola", "initials": "O"}, {"family": "Lovrenski", "given": "Jovan", "initials": "J"}, {"family": "Hirsch", "given": "Franz Wolfgang", "initials": "FW"}, {"family": "G\u00f6rkem", "given": "S\u00fcreyya Burcu", "initials": "SB"}, {"family": "Paterson", "given": "Anne", "initials": "A"}, {"family": "Arthurs", "given": "Owen J", "initials": "OJ"}, {"family": "Rossi", "given": "Andrea", "initials": "A"}, {"family": "van Schuppen", "given": "Joost", "initials": "J"}, {"family": "Petit", "given": "Philippe", "initials": "P"}, {"family": "Argyropoulou", "given": "Maria I", "initials": "MI"}, {"family": "Offiah", "given": "Amaka C", "initials": "AC"}, {"family": "Rosendahl", "given": "Karen", "initials": "K"}, {"family": "Caro-Dom\u00ednguez", "given": "Pablo", "initials": "P"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Pediatr Radiol", "issn": "1432-1998", "issn-l": null, "volume": "50", "issue": "9", "pages": "1313-1323"}, "abstract": "During the outbreak of the COVID-19 pandemic, guidelines have been issued by international, national and local authorities to address management and the need for preparedness. Children with COVID-19 differ from adults in that they are less often and less severely affected. Additional precautions required in the management of children address their increased radiosensitivity, need for accompanying carers, and methods for dealing with children in a mixed adult-paediatric institution. In this guidance document, our aim is to define a pragmatic strategy for imaging children with an emphasis on proven or suspected COVID-19 cases. Children suspected of COVID-19 should not be imaged routinely. Imaging should be performed only when expected to alter patient management, depending on symptoms, preexisting conditions and clinical evolution. In order to prevent disease transmission, it is important to manage the inpatient caseload effectively by triaging children and carers outside the hospital, re-scheduling nonurgent elective procedures and managing symptomatic children and carers as COVID-19 positive until proven otherwise. Within the imaging department one should consider conducting portable examinations with COVID-19 machines or arranging dedicated COVID-19 paediatric imaging sessions and performing routine nasopharyngeal swab testing before imaging under general anaesthesia. Finally, regular personal hygiene, appropriate usage of personal protective equipment, awareness of which procedures are considered aerosol generating and information on how to best disinfect imaging machinery after examinations should be highlighted to all staff members.", "doi": "10.1007/s00247-020-04749-3", "pmid": "32621013", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00247-020-04749-3"}, {"db": "pmc", "key": "PMC7332738"}], "notes": [], "created": "2020-12-08T15:05:31.524Z", "modified": "2020-12-11T12:52:07.380Z"}, {"entity": "publication", "iuid": "d6a624fb7c074de78500a3eff2f91098", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d6a624fb7c074de78500a3eff2f91098.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d6a624fb7c074de78500a3eff2f91098"}}, "title": "Lockdown timing and efficacy in controlling COVID-19 using mobile phone tracking.", "authors": [{"family": "Vinceti", "given": "Marco", "initials": "M"}, {"family": "Filippini", "given": "Tommaso", "initials": "T"}, {"family": "Rothman", "given": "Kenneth J", "initials": "KJ"}, {"family": "Ferrari", "given": "Fabrizio", "initials": "F"}, {"family": "Goffi", "given": "Alessia", "initials": "A"}, {"family": "Maffeis", "given": "Giuseppe", "initials": "G"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "issn-l": null, "volume": "25", "issue": null, "pages": "100457"}, "abstract": "Italy's severe COVID-19 outbreak was addressed by a lockdown that gradually increased in space, time and intensity. The effectiveness of the lockdown has not been precisely assessed with respect to the intensity of mobility restriction and the time until the outbreak receded.\r\n\r\nWe used processed mobile phone tracking data to measure mobility restriction, and related those data to the number of new SARS-CoV-2 positive cases detected on a daily base in the three most affected Italian regions, Lombardy, Veneto and Emilia-Romagna, from February 1 through April 6, 2020, when two subsequent lockdowns with increasing intensity were implemented by the Italian government.\r\n\r\nDuring the study period, mobility restriction was inversely related to the daily number of newly diagnosed SARS-CoV-2 positive cases only after the second, more effective lockdown, with a peak in the curve of diagnosed cases of infection occurring 14 to 18 days from lockdown in the three regions and 9 to 25 days in the included provinces. An effective reduction in transmission must have occurred nearly immediately after the tighter lockdown, given the lag time of around 10 days from asymptomatic infection to diagnosis. The period from lockdown to peak was shorter in the areas with the highest prevalence of the infection. This effect was seen within slightly more than one week in the most severely affected areas.\r\n\r\nIt appears that the less rigid lockdown led to an insufficient decrease in mobility to reverse an outbreak such as COVID-19. With a tighter lockdown, mobility decreased enough to bring down transmission promptly below the level needed to sustain the epidemic.\r\n\r\nNo funding sources have been used for this work.", "doi": "10.1016/j.eclinm.2020.100457", "pmid": "32838234", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(20)30201-7"}, {"db": "pii", "key": "100457"}, {"db": "pmc", "key": "PMC7355328"}], "notes": [], "created": "2020-12-07T10:32:00.513Z", "modified": "2022-11-10T07:23:24.584Z"}, {"entity": "publication", "iuid": "1ab8d8dc9a0c42f8925aafa2e839129f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ab8d8dc9a0c42f8925aafa2e839129f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ab8d8dc9a0c42f8925aafa2e839129f"}}, "title": "Investigation of a COVID-19 outbreak in Germany resulting from a single travel-associated primary case: a case series", "authors": [{"family": "B\u00f6hmer", "given": "Merle M", "initials": "MM"}, {"family": "Buchholz", "given": "Udo", "initials": "U"}, {"family": "Corman", "given": "Victor M", "initials": "VM"}, {"family": "Hoch", "given": "Martin", "initials": "M"}, {"family": "Katz", "given": "Katharina", "initials": "K"}, {"family": "Marosevic", "given": "Durdica V", "initials": "DV"}, {"family": "B\u00f6hm", "given": "Stefanie", "initials": "S"}, {"family": "Woudenberg", "given": "Tom", "initials": "T"}, {"family": "Ackermann", "given": "Nikolaus", "initials": "N"}, {"family": "Konrad", "given": "Regina", "initials": "R"}, {"family": "Eberle", "given": "Ute", "initials": "U"}, {"family": "Treis", "given": "Bianca", "initials": "B"}, {"family": "Dangel", "given": "Alexandra", "initials": "A"}, {"family": "Bengs", "given": "Katja", "initials": "K"}, {"family": "Fingerle", "given": "Volker", "initials": "V"}, {"family": "Berger", "given": "Anja", "initials": "A"}, {"family": "H\u00f6rmansdorfer", "given": "Stefan", "initials": "S"}, {"family": "Ippisch", "given": "Siegfried", "initials": "S"}, {"family": "Wicklein", "given": "Bernd", "initials": "B"}, {"family": "Grahl", "given": "Andreas", "initials": "A"}, {"family": "P\u00f6rtner", "given": "Kirsten", "initials": "K"}, {"family": "Muller", "given": "Nadine", "initials": "N"}, {"family": "Zeitlmann", "given": "Nadine", "initials": "N"}, {"family": "Boender", "given": "T Sonia", "initials": "TS"}, {"family": "Cai", "given": "Wei", "initials": "W"}, {"family": "Reich", "given": "Andreas", "initials": "A"}, {"family": "an der Heiden", "given": "Maria", "initials": "M"}, {"family": "Rexroth", "given": "Ute", "initials": "U"}, {"family": "Hamouda", "given": "Osamah", "initials": "O"}, {"family": "Schneider", "given": "Julia", "initials": "J"}, {"family": "Veith", "given": "Talitha", "initials": "T"}, {"family": "M\u00fchlemann", "given": "Barbara", "initials": "B"}, {"family": "W\u00f6lfel", "given": "Roman", "initials": "R"}, {"family": "Antwerpen", "given": "Markus", "initials": "M"}, {"family": "Walter", "given": "Mathias", "initials": "M"}, {"family": "Protzer", "given": "Ulrike", "initials": "U"}, {"family": "Liebl", "given": "Bernhard", "initials": "B"}, {"family": "Haas", "given": "Walter", "initials": "W"}, {"family": "Sing", "given": "Andreas", "initials": "A"}, {"family": "Drosten", "given": "Christian", "initials": "C"}, {"family": "Zapf", "given": "Andreas", "initials": "A"}], "type": "journal-article", "published": "2020-08-00", "journal": {"title": "The Lancet Infectious Diseases", "issn": "1473-3099", "volume": "20", "issue": "8", "pages": "920-928", "issn-l": null}, "abstract": "In December, 2019, the newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, causing COVID-19, a respiratory disease presenting with fever, cough, and often pneumonia. WHO has set the strategic objective to interrupt spread of SARS-CoV-2 worldwide. An outbreak in Bavaria, Germany, starting at the end of January, 2020, provided the opportunity to study transmission events, incubation period, and secondary attack rates.\n\nA case was defined as a person with SARS-CoV-2 infection confirmed by RT-PCR. Case interviews were done to describe timing of onset and nature of symptoms and to identify and classify contacts as high risk (had cumulative face-to-face contact with a confirmed case for \u226515 min, direct contact with secretions or body fluids of a patient with confirmed COVID-19, or, in the case of health-care workers, had worked within 2 m of a patient with confirmed COVID-19 without personal protective equipment) or low risk (all other contacts). High-risk contacts were ordered to stay at home in quarantine for 14 days and were actively followed up and monitored for symptoms, and low-risk contacts were tested upon self-reporting of symptoms. We defined fever and cough as specific symptoms, and defined a prodromal phase as the presence of non-specific symptoms for at least 1 day before the onset of specific symptoms. Whole genome sequencing was used to confirm epidemiological links and clarify transmission events where contact histories were ambiguous; integration with epidemiological data enabled precise reconstruction of exposure events and incubation periods. Secondary attack rates were calculated as the number of cases divided by the number of contacts, using Fisher's exact test for the 95% CIs.\n\nPatient 0 was a Chinese resident who visited Germany for professional reasons. 16 subsequent cases, often with mild and non-specific symptoms, emerged in four transmission generations. Signature mutations in the viral genome occurred upon foundation of generation 2, as well as in one case pertaining to generation 4. The median incubation period was 4\u00b70 days (IQR 2\u00b73-4\u00b73) and the median serial interval was 4\u00b70 days (3\u00b70-5\u00b70). Transmission events were likely to have occurred presymptomatically for one case (possibly five more), at the day of symptom onset for four cases (possibly five more), and the remainder after the day of symptom onset or unknown. One or two cases resulted from contact with a case during the prodromal phase. Secondary attack rates were 75\u00b70% (95% CI 19\u00b70-99\u00b70; three of four people) among members of a household cluster in common isolation, 10\u00b70% (1\u00b72-32\u00b70; two of 20) among household contacts only together until isolation of the patient, and 5\u00b71% (2\u00b76-8\u00b79; 11 of 217) among non-household, high-risk contacts.\n\nAlthough patients in our study presented with predominately mild, non-specific symptoms, infectiousness before or on the day of symptom onset was substantial. Additionally, the incubation period was often very short and false-negative tests occurred. These results suggest that although the outbreak was controlled, successful long-term and global containment of COVID-19 could be difficult to achieve.\n\nAll authors are employed and all expenses covered by governmental, federal state, or other publicly funded institutions.", "doi": "10.1016/s1473-3099(20)30314-5", "pmid": "32422201", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7228725"}, {"db": "pii", "key": "S1473-3099(20)30314-5"}], "notes": [], "created": "2020-12-10T08:57:10.569Z", "modified": "2023-06-19T15:24:24.557Z"}, {"entity": "publication", "iuid": "af81d5d1037f49c09189c3c0c55d609e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/af81d5d1037f49c09189c3c0c55d609e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/af81d5d1037f49c09189c3c0c55d609e"}}, "title": "Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity.", "authors": [{"family": "Guallar", "given": "Mar\u00eda Pilar", "initials": "MP"}, {"family": "Meiri\u00f1o", "given": "Rosa", "initials": "R"}, {"family": "Donat-Vargas", "given": "Carolina", "initials": "C"}, {"family": "Corral", "given": "Octavio", "initials": "O"}, {"family": "Jouv\u00e9", "given": "Nicol\u00e1s", "initials": "N"}, {"family": "Soriano", "given": "Vicente", "initials": "V"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": "97", "issue": null, "pages": "290-292"}, "abstract": "A relationship between the infecting dose and the risk of disease severity has not been demonstrated for SARS-CoV-2 infection. Here, we report three clusters of individuals that were potentially exposed to distinct inoculum in Madrid. Overall each group developed divergent clinical forms of COVID-19. Our data support that a greater viral inoculum at the time of SARS-CoV-2 exposure might determine a higher risk of severe COVID-19.", "doi": "10.1016/j.ijid.2020.06.035", "pmid": "32553720", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(20)30470-7"}, {"db": "pmc", "key": "PMC7293836"}], "notes": [], "created": "2020-12-09T07:48:44.715Z", "modified": "2021-02-26T08:45:48.582Z"}, {"entity": "publication", "iuid": "c1cd8bba32f3469cbe65a77299dc9595", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1cd8bba32f3469cbe65a77299dc9595.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1cd8bba32f3469cbe65a77299dc9595"}}, "title": "Inhalational volatile-based sedation for COVID-19 pneumonia and ARDS.", "authors": [{"family": "Jerath", "given": "Angela", "initials": "A"}, {"family": "Ferguson", "given": "Niall D", "initials": "ND"}, {"family": "Cuthbertson", "given": "Brian", "initials": "B"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "volume": "46", "issue": "8", "pages": "1563-1566", "issn-l": "0342-4642"}, "abstract": "Hospitals worldwide are experiencing a shortage in essential intravenous sedative medications. This is attributable to high number and high sedative needs of COVID-19 critical care patients with disruption of drug supply chains. Inhaled volatile anesthetic agents are an abundant resource and readily implementable solution for providing ICU sedation. Inhaled volatile agents may also provide important pulmonary benefits for COVID-19 patients with ARDS that could improve gas exchange and reduce time spent on a ventilator. We review the use of volatile agents, and provide a technical overview and algorithm for administering inhaled volatile-based sedation in ICUs.", "doi": "10.1007/s00134-020-06154-8", "pmid": "32588067", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-020-06154-8"}, {"db": "pmc", "key": "PMC7315695"}], "notes": [], "created": "2020-12-08T15:48:14.991Z", "modified": "2020-12-08T15:48:15.004Z"}, {"entity": "publication", "iuid": "9cf51abd932249898af01c24bd5289e3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9cf51abd932249898af01c24bd5289e3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9cf51abd932249898af01c24bd5289e3"}}, "title": "Impact of the COVID-19 pandemic on ongoing cardiovascular research projects: considerations and adaptations.", "authors": [{"family": "Van Bulck", "given": "Liesbet", "initials": "L"}, {"family": "Kovacs", "given": "Adrienne H", "initials": "AH"}, {"family": "Goossens", "given": "Eva", "initials": "E"}, {"family": "Luyckx", "given": "Koen", "initials": "K"}, {"family": "Jaarsma", "given": "Tiny", "initials": "T"}, {"family": "Str\u00f6mberg", "given": "Anna", "initials": "A"}, {"family": "Moons", "given": "Philip", "initials": "P"}], "type": "editorial", "published": "2020-08-00", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "volume": "19", "issue": "6", "pages": "465-468", "issn-l": null}, "abstract": null, "doi": "10.1177/1474515120926629", "pmid": "32418455", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-10T08:56:28.283Z", "modified": "2020-12-10T08:56:28.296Z"}, {"entity": "publication", "iuid": "137eb41ee24d46898ba5785cebd6f1df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/137eb41ee24d46898ba5785cebd6f1df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/137eb41ee24d46898ba5785cebd6f1df"}}, "title": "Hyperreninemia and low total body water may contribute to acute kidney injury in COVID-19 patients in intensive care.", "authors": [{"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "von Seth", "given": "Magnus", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "J Hypertens", "issn": "1473-5598", "issn-l": "0263-6352", "volume": "38", "issue": "8", "pages": "1613-1614"}, "abstract": "No abstract available", "doi": "10.1097/HJH.0000000000002531", "pmid": "32472780", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "NA", "key": "Provided in the article: biochemistry of patients in intensive care (N=9)", "description": null}], "notes": [], "created": "2020-10-30T11:42:00.648Z", "modified": "2021-02-26T08:45:02.849Z"}, {"entity": "publication", "iuid": "666b3cf7632f4444bc8e1b4aab6b02b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/666b3cf7632f4444bc8e1b4aab6b02b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/666b3cf7632f4444bc8e1b4aab6b02b4"}}, "title": "Global Survey on Pancreatic Surgery During the COVID-19 Pandemic.", "authors": [{"family": "Oba", "given": "Atsushi", "initials": "A"}, {"family": "Stoop", "given": "Thomas F", "initials": "TF"}, {"family": "L\u00f6hr", "given": "Matthias", "initials": "M"}, {"family": "Hackert", "given": "Thilo", "initials": "T"}, {"family": "Zyromski", "given": "Nicholas", "initials": "N"}, {"family": "Nealon", "given": "William H", "initials": "WH"}, {"family": "Unno", "given": "Michiaki", "initials": "M"}, {"family": "Schulick", "given": "Richard D", "initials": "RD"}, {"family": "Al-Musawi", "given": "Mohammed H", "initials": "MH"}, {"family": "Wu", "given": "Wenming", "initials": "W"}, {"family": "Zhao", "given": "Yupei", "initials": "Y"}, {"family": "Satoi", "given": "Sohei", "initials": "S"}, {"family": "Wolfgang", "given": "Christopher L", "initials": "CL"}, {"family": "Abu Hilal", "given": "Mohammad", "initials": "M"}, {"family": "Besselink", "given": "Marc G", "initials": "MG"}, {"family": "Del Chiaro", "given": "Marco", "initials": "M"}, {"family": "Pancreas Club, European Pancreatic Club, Chinese Pancreatic Surgery Association, European Consortium on Minimally Invasive Pancreatic Surgery, Study Group of Preoperative Therapy for Pancreatic Cancer, Study Group of Pancreatic Ductal Adenocarcinoma with Peritoneal Metastasis and International Study Group on Cystic Tumors of the Pancreas", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Ann Surg", "issn": "1528-1140", "volume": "272", "issue": "2", "pages": "e87-e93", "issn-l": null}, "abstract": "The aim of this study was to clarify the role of pancreatic surgery during the COVID-19 pandemic to optimize patients' and clinicians' safety and safeguard health care capacity.\n\nThe COVID-19 pandemic heavily impacts health care systems worldwide. Cancer patients appear to have an increased risk for adverse events when infected by COVID-19, but the inability to receive oncological care seems may be an even larger threat, particularly in case of pancreatic cancer.\n\nAn online survey was submitted to all members of seven international pancreatic associations and study groups, investigating the impact of the COVID-19 pandemic on pancreatic surgery using 21 statements (April, 2020). Consensus was defined as >80% agreement among respondents and moderate agreement as 60% to 80% agreement.\n\nA total of 337 respondents from 267 centers and 37 countries spanning 5 continents completed the survey. Most respondents were surgeons (n = 302, 89.6%) and working in an academic center (n = 286, 84.9%). The majority of centers (n = 166, 62.2%) performed less pancreatic surgery because of the COVID-19 pandemic, reducing the weekly pancreatic resection rate from 3 [interquartile range (IQR) 2-5] to 1 (IQR 0-2) (P < 0.001). Most centers screened for COVID-19 before pancreatic surgery (n = 233, 87.3%). Consensus was reached on 13 statements and 5 statements achieved moderate agreement.\n\nThis global survey elucidates the role of pancreatic surgery during the COVID-19 pandemic, regarding patient selection for the surgical and oncological treatment of pancreatic diseases to support clinical decision-making and creating a starting point for further discussion.", "doi": "10.1097/SLA.0000000000004006", "pmid": "32675507", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00000658-202008000-00027"}, {"db": "pmc", "key": "PMC7268883"}], "notes": [], "created": "2020-12-07T16:35:13.417Z", "modified": "2021-02-26T08:45:48.271Z"}, {"entity": "publication", "iuid": "19e27f15f057496f97f18f9b6d599e2e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19e27f15f057496f97f18f9b6d599e2e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19e27f15f057496f97f18f9b6d599e2e"}}, "title": "Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020.", "authors": [{"family": "Alm", "given": "Erik", "initials": "E"}, {"family": "Broberg", "given": "Eeva K", "initials": "EK"}, {"family": "Connor", "given": "Thomas", "initials": "T"}, {"family": "Hodcroft", "given": "Emma B", "initials": "EB"}, {"family": "Komissarov", "given": "Andrey B", "initials": "AB"}, {"family": "Maurer-Stroh", "given": "Sebastian", "initials": "S"}, {"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "Neher", "given": "Richard A", "initials": "RA"}, {"family": "O'Toole", "given": "\u00c1ine", "initials": "\u00c1"}, {"family": "Pereyaslov", "given": "Dmitriy", "initials": "D"}, {"family": "WHO European Region sequencing laboratories and GISAID EpiCoV group", "given": "", "initials": ""}, {"family": "WHO European Region sequencing laboratories and GISAID EpiCoV group*", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "32", "issn-l": null}, "abstract": "We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation, compare the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2.", "doi": "10.2807/1560-7917.ES.2020.25.32.2001410", "pmid": "32794443", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7427299"}], "notes": [], "created": "2020-12-07T13:23:05.531Z", "modified": "2021-02-26T08:46:12.957Z"}, {"entity": "publication", "iuid": "23cc455881f449c0a93ce9cff278ca53", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23cc455881f449c0a93ce9cff278ca53.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23cc455881f449c0a93ce9cff278ca53"}}, "title": "Flexibility and safety in times of coronavirus disease 2019 (COVID-19): Implications for nurses and allied professionals in cardiology.", "authors": [{"family": "Jaarsma", "given": "Tiny", "initials": "T"}, {"family": "van der Wal", "given": "Martje", "initials": "M"}, {"family": "Hinterbuchner", "given": "Lynne", "initials": "L"}, {"family": "K\u00f6berich", "given": "Stefan", "initials": "S"}, {"family": "Lie", "given": "Irene", "initials": "I"}, {"family": "Str\u00f6mberg", "given": "Anna", "initials": "A"}], "type": "editorial", "published": "2020-08-00", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "volume": "19", "issue": "6", "pages": "462-464", "issn-l": null}, "abstract": null, "doi": "10.1177/1474515120921027", "pmid": "32323572", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7441330"}], "notes": [], "created": "2020-12-09T14:53:50.944Z", "modified": "2020-12-09T14:53:50.954Z"}, {"entity": "publication", "iuid": "80bed42b5a9b45b296b0ca6afd771097", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/80bed42b5a9b45b296b0ca6afd771097.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/80bed42b5a9b45b296b0ca6afd771097"}}, "title": "Exercise in the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) era: A Question and Answer session with the experts Endorsed by the section of Sports Cardiology & Exercise of the European Association of Preventive Cardiology (EAPC).", "authors": [{"family": "Bhatia", "given": "Raghav T", "initials": "RT"}, {"family": "Marwaha", "given": "Sarandeep", "initials": "S"}, {"family": "Malhotra", "given": "Aneil", "initials": "A"}, {"family": "Iqbal", "given": "Zafar", "initials": "Z"}, {"family": "Hughes", "given": "Christopher", "initials": "C"}, {"family": "B\u00f6rjesson", "given": "Mats", "initials": "M"}, {"family": "Niebauer", "given": "Josef", "initials": "J"}, {"family": "Pelliccia", "given": "Antonio", "initials": "A"}, {"family": "Schmied", "given": "Christian", "initials": "C"}, {"family": "Serratosa", "given": "Luis", "initials": "L"}, {"family": "Papadakis", "given": "Michael", "initials": "M"}, {"family": "Sharma", "given": "Sanjay", "initials": "S"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Eur J Prev Cardiol", "issn": "2047-4881", "volume": "27", "issue": "12", "pages": "1242-1251", "issn-l": null}, "abstract": "Regular exercise has multiple benefits for physical and mental health, including the body's ability to combat infections. The current COVID-19 pandemic and the social distancing measures employed to curtail the impact of the infection are likely to reduce the amount of usual physical activity being performed by most individuals, including habitual exercisers. The uncertainties relating to the impact of the SARS-CoV-2 virus on the heart may cause increased anxiety, particularly in athletes who need to sustain a vigorous exercise regime in order to maintain their skills and fitness in preparation for return to competition after a short re-training period. The aim of this document is to provide practical answers to pertinent questions being posed by the sporting community, in an attempt to offer reassurance, promote safe participation in exercise during as well as after the COVID-19 pandemic and provide a framework of management for physicians caring for athletes.", "doi": "10.1177/2047487320930596", "pmid": "32475157", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-09T10:58:22.606Z", "modified": "2020-12-09T10:58:22.628Z"}, {"entity": "publication", "iuid": "336a049f34ae4df0a98f6b91d351915c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/336a049f34ae4df0a98f6b91d351915c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/336a049f34ae4df0a98f6b91d351915c"}}, "title": "European Task Force on Contact Dermatitis statement on coronavirus disease-19 (COVID-19) outbreak and the risk of adverse cutaneous reactions.", "authors": [{"family": "Balato", "given": "A", "initials": "A"}, {"family": "Ayala", "given": "F", "initials": "F"}, {"family": "Bruze", "given": "M", "initials": "M"}, {"family": "Crepy", "given": "M-N", "initials": "MN"}, {"family": "Gon\u00e7alo", "given": "M", "initials": "M"}, {"family": "Johansen", "given": "J", "initials": "J"}, {"family": "John", "given": "S M", "initials": "SM"}, {"family": "Pigatto", "given": "P", "initials": "P"}, {"family": "Raimondo", "given": "A", "initials": "A"}, {"family": "Rustemeyer", "given": "T", "initials": "T"}, {"family": "Schuttelaar", "given": "M-L A", "initials": "MA"}, {"family": "Svedman", "given": "C", "initials": "C"}, {"family": "Aerts", "given": "O", "initials": "O"}, {"family": "Uter", "given": "W", "initials": "W"}, {"family": "Wilkinson", "given": "M", "initials": "M"}, {"family": "Gimenez-Arnau", "given": "A", "initials": "A"}], "type": "letter", "published": "2020-08-00", "journal": {"title": "J Eur Acad Dermatol Venereol", "issn": "1468-3083", "volume": "34", "issue": "8", "pages": "e353-e354", "issn-l": null}, "abstract": null, "doi": "10.1111/jdv.16557", "pmid": "32356382", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-10T07:17:53.057Z", "modified": "2020-12-10T07:17:53.068Z"}, {"entity": "publication", "iuid": "e3aae2291569457e80d5f36dff065efc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3aae2291569457e80d5f36dff065efc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3aae2291569457e80d5f36dff065efc"}}, "title": "Estimation of the COVID-19 burden in Egypt through exported case detection.", "authors": [{"family": "Tuite", "given": "Ashleigh R", "initials": "AR"}, {"family": "Ng", "given": "Victoria", "initials": "V"}, {"family": "Rees", "given": "Erin", "initials": "E"}, {"family": "Fisman", "given": "David", "initials": "D"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Khan", "given": "Kamran", "initials": "K"}, {"family": "Bogoch", "given": "Isaac I", "initials": "II"}], "type": "letter", "published": "2020-08-00", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "volume": "20", "issue": "8", "pages": "894", "issn-l": null}, "abstract": null, "doi": "10.1016/S1473-3099(20)30233-4", "pmid": "32222162", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(20)30233-4"}, {"db": "pmc", "key": "PMC7195316"}], "notes": [], "created": "2020-12-10T08:58:07.204Z", "modified": "2020-12-10T08:58:07.215Z"}, {"entity": "publication", "iuid": "41aacb23f79843de9c9fd92f17eadda4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41aacb23f79843de9c9fd92f17eadda4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41aacb23f79843de9c9fd92f17eadda4"}}, "title": "Estimation of COVID-19 burden in Egypt - Authors' reply.", "authors": [{"family": "Tuite", "given": "Ashleigh R", "initials": "AR"}, {"family": "Ng", "given": "Victoria", "initials": "V"}, {"family": "Rees", "given": "Erin", "initials": "E"}, {"family": "Fisman", "given": "David", "initials": "D"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Khan", "given": "Kamran", "initials": "K"}, {"family": "Bogoch", "given": "Isaac I", "initials": "II"}], "type": "letter", "published": "2020-08-00", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "volume": "20", "issue": "8", "pages": "897-898", "issn-l": null}, "abstract": null, "doi": "10.1016/S1473-3099(20)30326-1", "pmid": "32353344", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(20)30326-1"}, {"db": "pmc", "key": "PMC7185943"}], "notes": [], "created": "2020-12-10T07:16:28.263Z", "modified": "2020-12-10T07:16:28.272Z"}, {"entity": "publication", "iuid": "8b7103dffee443d1b2b330f2beec8184", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b7103dffee443d1b2b330f2beec8184.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b7103dffee443d1b2b330f2beec8184"}}, "title": "Delivery of hepato-pancreato-biliary surgery during the COVID-19 pandemic: an European-African Hepato-Pancreato-Biliary Association (E-AHPBA) cross-sectional survey.", "authors": [{"family": "Balakrishnan", "given": "Anita", "initials": "A"}, {"family": "Lesurtel", "given": "Mickael", "initials": "M"}, {"family": "Siriwardena", "given": "Ajith K", "initials": "AK"}, {"family": "Heinrich", "given": "Stefan", "initials": "S"}, {"family": "Serrablo", "given": "Alejandro", "initials": "A"}, {"family": "Besselink", "given": "Marc G H", "initials": "MGH"}, {"family": "Erkan", "given": "Mert", "initials": "M"}, {"family": "Andersson", "given": "Bodil", "initials": "B"}, {"family": "Polak", "given": "Wojciech G", "initials": "WG"}, {"family": "Laurenzi", "given": "Andrea", "initials": "A"}, {"family": "Olde Damink", "given": "Stefan W M", "initials": "SWM"}, {"family": "Berrevoet", "given": "Frederik", "initials": "F"}, {"family": "Frigerio", "given": "Isabella", "initials": "I"}, {"family": "Ramia", "given": "Jose M", "initials": "JM"}, {"family": "Gallagher", "given": "Thomas K", "initials": "TK"}, {"family": "Warner", "given": "Susanne", "initials": "S"}, {"family": "Shrikhande", "given": "Shailesh V", "initials": "SV"}, {"family": "Adam", "given": "Rene", "initials": "R"}, {"family": "Smith", "given": "Martin D", "initials": "MD"}, {"family": "Conlon", "given": "Kevin C", "initials": "KC"}, {"family": "E-AHPBA Scientific and Research Committee", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "HPB (Oxford)", "issn": "1477-2574", "volume": "22", "issue": "8", "pages": "1128-1134", "issn-l": null}, "abstract": "The extent of the COVID-19 pandemic and the resulting response has varied globally. The European and African Hepato-Pancreato-Biliary Association (E-AHPBA), the premier representative body for practicing HPB surgeons in Europe and Africa, conducted this survey to assess the impact of COVID-19 on HPB surgery.\n\nAn online survey was disseminated to all E-AHPBA members to assess the effects of the pandemic on unit capacity, management of HPB cancers, use of COVID-19 screening and other aspects of service delivery.\n\nOverall, 145 (25%) members responded. Most units, particularly in COVID-high countries (>100,000 cases) reported insufficient critical care capacity and reduced HPB operating sessions compared to COVID-low countries. Delayed access to cancer surgery necessitated alternatives including increased neoadjuvant chemotherapy for pancreatic cancer and colorectal liver metastases, and locoregional treatments for hepatocellular carcinoma. Other aspects of service delivery including COVID-19 screening and personal protective equipment varied between units and countries.\n\nThis study demonstrates that the COVID-19 pandemic has had a profound adverse impact on the delivery of HPB cancer care across the continents of Europe and Africa. The findings illustrate the need for safe resumption of cancer surgery in a \"new\" normal world with screening of patients and staff for COVID-19.", "doi": "10.1016/j.hpb.2020.05.012", "pmid": "32565039", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S1365-182X(20)31040-6"}, {"db": "pmc", "key": "PMC7284265"}], "notes": [], "created": "2020-12-08T16:33:29.400Z", "modified": "2021-02-26T08:46:13.366Z"}, {"entity": "publication", "iuid": "311ba3cc55dd4405af16b70d0fa700b7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/311ba3cc55dd4405af16b70d0fa700b7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/311ba3cc55dd4405af16b70d0fa700b7"}}, "title": "Delivering healthcare remotely to cardiovascular patients during COVID-19 : A rapid review of the evidence.", "authors": [{"family": "Neubeck", "given": "Lis", "initials": "L"}, {"family": "Hansen", "given": "Tina", "initials": "T"}, {"family": "Jaarsma", "given": "Tiny", "initials": "T"}, {"family": "Klompstra", "given": "Leonie", "initials": "L"}, {"family": "Gallagher", "given": "Robyn", "initials": "R"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "volume": "19", "issue": "6", "pages": "486-494", "issn-l": null}, "abstract": "Although attention is focused on addressing the acute situation created by the COVID-19 illness, it is imperative to continue our efforts to prevent cardiovascular morbidity and mortality, particularly during a period of prolonged social isolation which may limit physical activity, adversely affect mental health and reduce access to usual care. One option may be to deliver healthcare interventions remotely through digital healthcare solutions. Therefore, the aim of this paper is to bring together the evidence for remote healthcare during a quarantine situation period to support people living with cardiovascular disease during COVID-19 isolation.\n\nThe PubMed, CINAHL and Google Scholar were searched using telehealth OR digital health OR mHealth OR eHealth OR mobile apps AND COVID-19 OR quarantine search terms. We also searched for literature relating to cardiovascular disease AND quarantine.\n\nThe literature search identified 45 potentially relevant publications, out of which nine articles were included. Three overarching themes emerged from this review: (1) preparing the workforce and ensuring reimbursement for remote healthcare, (2) supporting mental and physical health and (3) supporting usual care.\n\nTo support people living with cardiovascular disease during COVID-19 isolation and to mitigate the effects of quarantine and adverse effect on mental and physical well-being, we should offer remote healthcare and provide access to their usual care.", "doi": "10.1177/1474515120924530", "pmid": "32380858", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-30T09:10:05.652Z", "modified": "2020-11-30T09:10:05.676Z"}, {"entity": "publication", "iuid": "9d81995f5daf410da34016e079e9bd0a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9d81995f5daf410da34016e079e9bd0a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9d81995f5daf410da34016e079e9bd0a"}}, "title": "Dealing with sleep problems during home confinement due to the COVID-19 outbreak: Practical recommendations from a task force of the European CBT-I Academy.", "authors": [{"family": "Altena", "given": "Ellemarije", "initials": "E"}, {"family": "Baglioni", "given": "Chiara", "initials": "C"}, {"family": "Espie", "given": "Colin A", "initials": "CA"}, {"family": "Ellis", "given": "Jason", "initials": "J"}, {"family": "Gavriloff", "given": "Dimitri", "initials": "D"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Schlarb", "given": "Angelika", "initials": "A"}, {"family": "Frase", "given": "Lukas", "initials": "L"}, {"family": "Jernel\u00f6v", "given": "Susanna", "initials": "S"}, {"family": "Riemann", "given": "Dieter", "initials": "D"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "J Sleep Res", "issn": "1365-2869", "volume": "29", "issue": "4", "pages": "e13052", "issn-l": "0962-1105"}, "abstract": "Editorial\r\n\r\nIn the current global home confinement situation due to the COVID-19 outbreak, most individuals are exposed to an unprecedented stressful situation of unknown duration. This may not only increase daytime stress, anxiety and depression levels, but also disrupt sleep. Importantly, because of the fundamental role that sleep plays in emotion regulation, sleep disturbance can have direct consequences upon next day emotional functioning. In this paper, we summarize what is known about the stress-sleep link and confinement as well as effective insomnia treatment. We discuss those effects of the current home confinement situation that can disrupt sleep but also those that could benefit sleep quality. We suggest adaptions of cognitive behavioural therapy elements that are feasible to implement for those facing changed work schedules and requirements, those with health anxiety and those handling childcare and home-schooling, whilst also recognizing the general limitations imposed on physical exercise and social interaction. Managing sleep problems as best as possible during home confinement can limit stress and possibly prevent disruptions of social relationships.", "doi": "10.1111/jsr.13052", "pmid": "32246787", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-25T07:26:15.028Z", "modified": "2020-11-30T15:56:39.059Z"}, {"entity": "publication", "iuid": "2ab907e81c514e46a3d203d801cff0ad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ab907e81c514e46a3d203d801cff0ad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ab907e81c514e46a3d203d801cff0ad"}}, "title": "D-dimer in patients infected with COVID-19 and suspected pulmonary embolism.", "authors": [{"family": "Garcia-Oliv\u00e9", "given": "Ignasi", "initials": "I"}, {"family": "Sintes", "given": "Helena", "initials": "H"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Abad Capa", "given": "Jorge", "initials": "J"}, {"family": "Rosell", "given": "Antoni", "initials": "A"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Respir Med", "issn": "1532-3064", "volume": "169", "issue": null, "pages": "106023", "issn-l": "0954-6111"}, "abstract": "To analyze the risk factors for pulmonary embolism (PE) in patients infected with COVID-19.\n\nWe conducted an observational, retrospective study. Patients with severe infection with COVID-19 and suspected PE were included.\n\nPatients with higher levels of D-dimer and those requiring intubation were at a higher risk of developing PE. Higher D-dimer levels were associated with a greater probability of PE 3, 6, 9 and 12 days after determining D-dimer levels with an OR of 1.7, 2.0, 2.4 and 2.4, respectively.\n\nIn conclusion, patients infected with COVID-19 requiring OTI with higher levels of D-dimer have an increased risk of developing PE.", "doi": "10.1016/j.rmed.2020.106023", "pmid": "32454268", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S0954-6111(20)30163-3"}, {"db": "pmc", "key": "PMC7219417"}], "notes": [], "created": "2020-11-25T09:15:41.624Z", "modified": "2021-02-26T08:45:02.911Z"}, {"entity": "publication", "iuid": "fc7182e6cfb14b3687e06c6a096d218f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc7182e6cfb14b3687e06c6a096d218f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc7182e6cfb14b3687e06c6a096d218f"}}, "title": "Children are unlikely to be the main drivers of the COVID-19 pandemic - A systematic review.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "volume": "109", "issue": "8", "pages": "1525-1530", "issn-l": null}, "abstract": "Many countries have closed schools and kindergartens to minimise COVID-19, but the role that children play in disease transmission is unclear.\r\n\r\nA systematic literature review of the MEDLINE and EMBASE databases and medRxiv/bioRxiv preprint servers to 11 May 2020 identified published and unpublished papers on COVID-19 transmission by children.\r\n\r\nWe identified 700 scientific papers and letters and 47 full texts were studied in detail. Children accounted for a small fraction of COVID-19 cases and mostly had social contacts with peers or parents, rather than older people at risk of severe disease. Data on viral loads were scarce, but indicated that children may have lower levels than adults, partly because they often have fewer symptoms, and this should decrease the transmission risk. Household transmission studies showed that children were rarely the index case and case studies suggested that children with COVID-19 seldom caused outbreaks. However, it is highly likely that children can transmit the SARS-COV-2 virus, which causes COVID-19, and even asymptomatic children can have viral loads.\r\n\r\nChildren are unlikely to be the main drivers of the pandemic. Opening up schools and kindergartens is unlikely to impact COVID-19 mortality rates in older people.", "doi": "10.1111/apa.15371", "pmid": "32430964", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-04T15:37:40.145Z", "modified": "2020-11-26T12:12:34.222Z"}, {"entity": "publication", "iuid": "4516da93170f4a63955ab4a4014f3836", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4516da93170f4a63955ab4a4014f3836.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4516da93170f4a63955ab4a4014f3836"}}, "title": "COVID-19 and neurointerventional service worldwide: a survey of the European Society of Minimally Invasive Neurological Therapy (ESMINT), the Society of NeuroInterventional Surgery (SNIS), the Sociedad Iberolatinoamericana de Neuroradiologia Diagnostica y Terapeutica (SILAN), the Society of Vascular and Interventional Neurology (SVIN), and the World Federation of Interventional and Therapeutic Neuroradiology (WFITN).", "authors": [{"family": "Fiehler", "given": "Jens", "initials": "J"}, {"family": "Brouwer", "given": "Patrick", "initials": "P"}, {"family": "D\u00edaz", "given": "Carlos", "initials": "C"}, {"family": "Hirsch", "given": "Joshua A", "initials": "JA"}, {"family": "Kulcsar", "given": "Zsolt", "initials": "Z"}, {"family": "Liebeskind", "given": "David", "initials": "D"}, {"family": "Linfante", "given": "Italo", "initials": "I"}, {"family": "Lylyk", "given": "Pedro", "initials": "P"}, {"family": "Mack", "given": "William J", "initials": "WJ"}, {"family": "Milburn", "given": "James", "initials": "J"}, {"family": "Nogueira", "given": "Raul", "initials": "R"}, {"family": "Orbach", "given": "Darren B", "initials": "DB"}, {"family": "Pumar", "given": "Jos\u00e9 Manuel Manuel", "initials": "JMM"}, {"family": "Tanaka", "given": "Michihiro", "initials": "M"}, {"family": "Taylor", "given": "Allan", "initials": "A"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "J Neurointerv Surg", "issn": "1759-8486", "volume": "12", "issue": "8", "pages": "726-730", "issn-l": "1759-8478"}, "abstract": "This survey was focused on the provision of neurointerventional services, the current practices of managing patients under COVID-19 conditions, and the expectations for the future.\n\nInvitations for this survey were sent out as a collaborative effort of the European Society of Minimally Invasive Neurological Therapy (ESMINT), the Society of NeuroInterventional Surgery (SNIS), the Sociedad Iberolatinoamericana de Neuroradiologia Diagnostica y Terapeutica (SILAN), the Society of Vascular and Interventional Neurology (SVIN), and the World Federation of Interventional and Therapeutic Neuroradiology (WFITN).\n\nOverall, 475 participants from 61 countries responded (six from Africa (1%), 81 from Asia (17%), 156 from Europe (33%), 53 from Latin America (11%), and 172 from North America (11%)). The majority of participants (96%) reported being able to provide emergency services, though 26% of these reported limited resources. A decrease in emergency procedures was reported by 69% of participants (52% in ischemic and hemorrhagic stroke, 11% ischemic, and 6% hemorrhagic stroke alone). Only 4% reported an increase in emergency cases. The emerging need for social distancing and the rapid adoption of remote communication was reflected in the interest in establishing case discussion forums (43%), general online forums (37%), and access to angio video streaming for live mentoring and support (33%).\n\nNeurointerventional emergency services are available in almost all centers, while the number of emergency patients is markedly decreased. Half of the participants have abandoned neurointerventions in non-emergent situations. There are considerable variations in the management of neurointerventions and in the expectations for the future.", "doi": "10.1136/neurintsurg-2020-016349", "pmid": "32546635", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "neurintsurg-2020-016349"}, {"db": "pmc", "key": "PMC7316120"}], "notes": [], "created": "2020-12-09T07:51:50.699Z", "modified": "2021-02-26T08:45:02.973Z"}, {"entity": "publication", "iuid": "a7cea9e2b86b45dc86bb5fd882d4aff0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7cea9e2b86b45dc86bb5fd882d4aff0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7cea9e2b86b45dc86bb5fd882d4aff0"}}, "title": "Building an international consortium for tracking coronavirus health status.", "authors": [{"family": "Segal", "given": "Eran", "initials": "E"}, {"family": "Zhang", "given": "Feng", "initials": "F"}, {"family": "Lin", "given": "Xihong", "initials": "X"}, {"family": "King", "given": "Gary", "initials": "G"}, {"family": "Shalem", "given": "Ophir", "initials": "O"}, {"family": "Shilo", "given": "Smadar", "initials": "S"}, {"family": "Allen", "given": "William E", "initials": "WE"}, {"family": "Alquaddoomi", "given": "Faisal", "initials": "F"}, {"family": "Altae-Tran", "given": "Han", "initials": "H"}, {"family": "Anders", "given": "Simon", "initials": "S"}, {"family": "Balicer", "given": "Ran", "initials": "R"}, {"family": "Bauman", "given": "Tal", "initials": "T"}, {"family": "Bonilla", "given": "Ximena", "initials": "X"}, {"family": "Booman", "given": "Gisel", "initials": "G"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "Cohen", "given": "Ori", "initials": "O"}, {"family": "Coletti", "given": "Silvano", "initials": "S"}, {"family": "Davidson", "given": "Natalie", "initials": "N"}, {"family": "Dor", "given": "Yuval", "initials": "Y"}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Elemento", "given": "Olivier", "initials": "O"}, {"family": "Evans", "given": "Georgina", "initials": "G"}, {"family": "Ewels", "given": "Phil", "initials": "P"}, {"family": "Gale", "given": "Joshua", "initials": "J"}, {"family": "Gavrieli", "given": "Amir", "initials": "A"}, {"family": "Geiger", "given": "Benjamin", "initials": "B"}, {"family": "Grad", "given": "Yonatan H", "initials": "YH"}, {"family": "Greene", "given": "Casey S", "initials": "CS"}, {"family": "Hajirasouliha", "given": "Iman", "initials": "I"}, {"family": "Jerala", "given": "Roman", "initials": "R"}, {"family": "Kahles", "given": "Andre", "initials": "A"}, {"family": "Kallioniemi", "given": "Olli", "initials": "O"}, {"family": "Keshet", "given": "Ayya", "initials": "A"}, {"family": "Kocarev", "given": "Ljupco", "initials": "L"}, {"family": "Landua", "given": "Gregory", "initials": "G"}, {"family": "Meir", "given": "Tomer", "initials": "T"}, {"family": "Muller", "given": "Aline", "initials": "A"}, {"family": "Nguyen", "given": "Long H", "initials": "LH"}, {"family": "Oresic", "given": "Matej", "initials": "M"}, {"family": "Ovchinnikova", "given": "Svetlana", "initials": "S"}, {"family": "Peterson", "given": "Hedi", "initials": "H"}, {"family": "Prodanova", "given": "Jana", "initials": "J"}, {"family": "Rajagopal", "given": "Jay", "initials": "J"}, {"family": "R\u00e4tsch", "given": "Gunnar", "initials": "G"}, {"family": "Rossman", "given": "Hagai", "initials": "H"}, {"family": "Rung", "given": "Johan", "initials": "J"}, {"family": "Sboner", "given": "Andrea", "initials": "A"}, {"family": "Sigaras", "given": "Alexandros", "initials": "A"}, {"family": "Spector", "given": "Tim", "initials": "T"}, {"family": "Steinherz", "given": "Ron", "initials": "R"}, {"family": "Stevens", "given": "Irene", "initials": "I"}, {"family": "Vilo", "given": "Jaak", "initials": "J"}, {"family": "Wilmes", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "volume": "26", "issue": "8", "pages": "1161-1165", "issn-l": "1078-8956"}, "abstract": null, "doi": "10.1038/s41591-020-0929-x", "pmid": "32488218", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-020-0929-x"}], "notes": [], "created": "2020-11-19T19:23:03.049Z", "modified": "2020-11-19T19:23:03.069Z"}, {"entity": "publication", "iuid": "023eb43b041b4e50be5765fade3a9d5e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/023eb43b041b4e50be5765fade3a9d5e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/023eb43b041b4e50be5765fade3a9d5e"}}, "title": "Assessing the psychological response to the COVID-19: A response to Bitan et al. \"Fear of COVID-19 scale: Psychometric characteristics, reliability and validity in the Israeli population\".", "authors": [{"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}], "type": "letter", "published": "2020-08-00", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "volume": "290", "issue": null, "pages": "113127", "issn-l": null}, "abstract": null, "doi": "10.1016/j.psychres.2020.113127", "pmid": "32502825", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(20)31547-X"}, {"db": "pmc", "key": "PMC7255140"}], "notes": [], "created": "2020-12-09T10:35:34.375Z", "modified": "2020-12-09T10:35:34.397Z"}, {"entity": "publication", "iuid": "11aa61844aa54c8fb17c8c1c81416cae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/11aa61844aa54c8fb17c8c1c81416cae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/11aa61844aa54c8fb17c8c1c81416cae"}}, "title": "Symptom Relief Is Possible in Elderly Dying COVID-19 Patients: A National Register Study.", "authors": [{"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "Bergstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Staffan", "initials": "S"}], "type": "journal article", "published": "2020-07-31", "journal": {"title": "J Palliat Med", "issn": "1557-7740", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Increasing numbers of people dying from COVID-19 are reported, but data are lacking on the way they die. Background: To study symptoms and symptom relief during the last week of life, comparing nursing homes with hospitals. Objective: The Swedish Register of Palliative Care with national coverage was used. Breakthrough symptoms were registered as Yes/No. Symptom relief was recorded on a 3-grade scale as Design: complete-partial-no relief. All deaths in COVID-19 were contrasted to deaths in a reference population (deaths 2019). Deaths at nursing homes were compared with deaths in hospitals. All deaths in hospitals or nursing homes (Setting and Subjects: n = 490) were analyzed. Deaths in other settings (specialized palliative care wards [n = 11], in palliative home care [n = 2], or in their own homes [n = 8]) were excluded (n = 21). Only patients with expected deaths (n = 390) were entered in the final analysis. Breathlessness as a breakthrough symptom was more common in COVID-19 patients than in the 2019 reference population (Results: p < 0.001) and relief of breathlessness, as well as anxiety, delirium, and death rattles was less successful in COVID-19 patients (p < 0.05 to p < 0.01 in different comparisons). Patients were older in nursing homes than in hospitals (86.6 years vs. 80.9 years, p < 0.001) and more often female (48% vs. 34%, p < 0.001). Breakthrough of breathlessness was much more frequently reported in hospital settings than in nursing homes, 73% versus 35% (p < 0.0001), and complete relief was more rarely possible in hospitals, 20% versus 42% (p < 0.01). The proportion of partial relief+complete relief was comparable, 92% versus 95% (ns). Also, anxiety and pain were more often completely relieved in nursing homes (p < 0.01 in both comparisons). The lower symptom prevalence in nursing homes may be explained by elderly frail residents dying already in the first phase of the COVID-19 disease, before acute respiratory distress syndrome develops.Conclusion:", "doi": "10.1089/jpm.2020.0249", "pmid": "32746685", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-07T16:02:24.617Z", "modified": "2022-11-10T07:29:58.676Z"}, {"entity": "publication", "iuid": "afa38fbb53ff4312b9b378bee719af74", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/afa38fbb53ff4312b9b378bee719af74.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/afa38fbb53ff4312b9b378bee719af74"}}, "title": "Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories", "authors": [{"family": "Su", "given": "Yapeng", "initials": "Y"}, {"family": "Chen", "given": "Daniel", "initials": "D"}, {"family": "Lausted", "given": "Christopher", "initials": "C"}, {"family": "Yuan", "given": "Dan", "initials": "D"}, {"family": "Choi", "given": "Jongchan", "initials": "J"}, {"family": "Dai", "given": "Cheng", "initials": "C"}, {"family": "Voillet", "given": "Valentin", "initials": "V"}, {"family": "Scherler", "given": "Kelsey", "initials": "K"}, {"family": "Troisch", "given": "Pamela", "initials": "P"}, {"family": "Duvvuri", "given": "Venkata R", "initials": "VR"}, {"family": "Baloni", "given": "Priyanka", "initials": "P"}, {"family": "Qin", "given": "Guangrong", "initials": "G"}, {"family": "Smith", "given": "Brett", "initials": "B"}, {"family": "Kornilov", "given": "Sergey", "initials": "S"}, {"family": "Rostomily", "given": "Clifford", "initials": "C"}, {"family": "Xu", "given": "Alex", "initials": "A"}, {"family": "Li", "given": "Jing", "initials": "J"}, {"family": "Dong", "given": "Shen", "initials": "S"}, {"family": "Rothchild", "given": "Alissa", "initials": "A"}, {"family": "Zhou", "given": "Jing", "initials": "J"}, {"family": "Murray", "given": "Kim", "initials": "K"}, {"family": "Edmark", "given": "Rick", "initials": "R"}, {"family": "Hong", "given": "Sunga", "initials": "S"}, {"family": "Jones", "given": "Lesley", "initials": "L"}, {"family": "Zhou", "given": "Yong", "initials": "Y"}, {"family": "Roper", "given": "Ryan", "initials": "R"}, {"family": "Mackay", "given": "Sean", "initials": "S"}, {"family": "O\u2019Mahony", "given": "D Shane", "initials": "DS"}, {"family": "Dale", "given": "Christopher R", "initials": "CR"}, {"family": "Wallick", "given": "Julie A", "initials": "JA"}, {"family": "Algren", "given": "Heather A", "initials": "HA"}, {"family": "Michael", "given": "Zager A", "initials": "ZA"}, {"family": "Magis", "given": "Andrew", "initials": "A"}, {"family": "Wei", "given": "Wei", "initials": "W"}, {"family": "Price", "given": "Nathan D", "initials": "ND"}, {"family": "Huang", "given": "Sui", "initials": "S"}, {"family": "Subramanian", "given": "Naeha", "initials": "N"}, {"family": "Wang", "given": "Kai", "initials": "K"}, {"family": "Hadlock", "given": "Jennifer", "initials": "J"}, {"family": "Hood", "given": "Leroy", "initials": "L"}, {"family": "Aderem", "given": "Alan", "initials": "A"}, {"family": "Bluestone", "given": "Jeffrey A", "initials": "JA"}, {"family": "Lanier", "given": "Lewis L", "initials": "LL"}, {"family": "Greenberg", "given": "Phil", "initials": "P"}, {"family": "Gottardo", "given": "Raphael", "initials": "R"}, {"family": "Davis", "given": "Mark M", "initials": "MM"}, {"family": "Goldman", "given": "Jason D", "initials": "JD"}, {"family": "Heath", "given": "James R", "initials": "JR"}, {"family": "None", "given": "", "initials": ""}], "type": "posted-content", "published": "2020-07-28", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.07.27.224063", "pmid": null, "labels": {"Type: Preprint": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "ArrayExpress", "key": "https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-9357/samples/", "description": "Processed data on samples and derived array files are available on ArrayExpress"}, {"db": "ISB COVID-19 Data Explorer", "key": "https://atlas.fredhutch.org/isb/covid/", "description": "Data integrated for further visualisation and analysis"}, {"db": "NA", "key": "pseudonymized RNA sequencing data available upon request from corresponding author (Due to potential risk of de-identification)", "description": null}], "notes": [], "created": "2021-01-08T08:58:17.158Z", "modified": "2021-11-18T08:28:15.341Z"}, {"entity": "publication", "iuid": "47b56a3f9d6546dc935a3bdbdd4b2315", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47b56a3f9d6546dc935a3bdbdd4b2315.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47b56a3f9d6546dc935a3bdbdd4b2315"}}, "title": "Importance of Inclusion of Pregnant and Breastfeeding Women in COVID-19 Therapeutic Trials.", "authors": [{"family": "LaCourse", "given": "Sylvia", "initials": "S"}, {"family": "John-Stewart", "given": "Grace", "initials": "G"}, {"family": "Adams Waldorf", "given": "Kristina M", "initials": "KM"}], "type": "journal article", "published": "2020-07-28", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "volume": "71", "issue": "15", "pages": "879-881", "issn-l": "1058-4838"}, "abstract": "Investigators are employing unprecedented innovation in the design of clinical trials to rapidly and rigorously assess potentially promising therapies for coronavirus disease 2019 (COVID-19); this is in stark contrast to the continued near-universal regressive practice of exclusion of pregnant and breastfeeding women from these trials. The few trials that allow their inclusion focus on postexposure prophylaxis or outpatient treatment of milder disease, limiting the options available to pregnant women with severe COVID-19 to compassionate use of remdesivir, or off-label drug use of hydroxychloroquine or other therapies. These restrictions were put in place despite experience with these drugs in pregnant women. In this Viewpoint, we call attention to the need and urgency to engage pregnant women in COVID-19 treatment trials now in order to develop data-driven recommendations regarding the risks and benefits of therapies in this unique but not uncommon population.", "doi": "10.1093/cid/ciaa444", "pmid": "32296817", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5820683"}, {"db": "pmc", "key": "PMC7184504"}], "notes": [], "created": "2020-12-09T14:47:38.472Z", "modified": "2020-12-09T14:47:38.490Z"}, {"entity": "publication", "iuid": "df6d1ea6bc7443daabbea5f510146e0d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/df6d1ea6bc7443daabbea5f510146e0d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/df6d1ea6bc7443daabbea5f510146e0d"}}, "title": "Generalizability of Coronavirus Disease 2019 (COVID-19) Clinical Prediction Models.", "authors": [{"family": "Hooli", "given": "Shubhada", "initials": "S"}, {"family": "King", "given": "Carina", "initials": "C"}], "type": "letter", "published": "2020-07-28", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "volume": "71", "issue": "15", "pages": "897", "issn-l": "1058-4838"}, "abstract": null, "doi": "10.1093/cid/ciaa417", "pmid": "32271865", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5818447"}, {"db": "pmc", "key": "PMC7184363"}], "notes": [], "created": "2020-11-22T17:15:23.515Z", "modified": "2020-11-22T17:15:23.526Z"}, {"entity": "publication", "iuid": "97538cd2ee6649578f2a9df8210012f6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/97538cd2ee6649578f2a9df8210012f6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/97538cd2ee6649578f2a9df8210012f6"}}, "title": "Computational Studies of SARS-CoV-2 3CLpro: Insights from MD Simulations.", "authors": [{"family": "Grottesi", "given": "Alessandro", "initials": "A"}, {"family": "Be\u0161ker", "given": "Neva", "initials": "N"}, {"family": "Emerson", "given": "Andrew", "initials": "A"}, {"family": "Manelfi", "given": "Candida", "initials": "C"}, {"family": "Beccari", "given": "Andrea R", "initials": "AR"}, {"family": "Frigerio", "given": "Francesco", "initials": "F"}, {"family": "Lindahl", "given": "Erik", "initials": "E"}, {"family": "Cerchia", "given": "Carmen", "initials": "C"}, {"family": "Talarico", "given": "Carmine", "initials": "C"}], "type": "journal article", "published": "2020-07-28", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "21", "issue": "15", "issn-l": null}, "abstract": "Given the enormous social and health impact of the pandemic triggered by severe acute respiratory syndrome 2 (SARS-CoV-2), the scientific community made a huge effort to provide an immediate response to the challenges posed by Coronavirus disease 2019 (COVID-19). One of the most important proteins of the virus is an enzyme, called 3CLpro or main protease, already identified as an important pharmacological target also in SARS and Middle East respiratory syndrome virus (MERS) viruses. This protein triggers the production of a whole series of enzymes necessary for the virus to carry out its replicating and infectious activities. Therefore, it is crucial to gain a deeper understanding of 3CLpro structure and function in order to effectively target this enzyme. All-atoms molecular dynamics (MD) simulations were performed to examine the different conformational behaviors of the monomeric and dimeric form of SARS-CoV-2 3CLpro apo structure, as revealed by microsecond time scale MD simulations. Our results also shed light on the conformational dynamics of the loop regions at the entry of the catalytic site. Studying, at atomic level, the characteristics of the active site and obtaining information on how the protein can interact with its substrates will allow the design of molecules able to block the enzymatic function crucial for the virus.", "doi": "10.3390/ijms21155346", "pmid": "32731361", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Imaging": null}, "xrefs": [{"db": "pii", "key": "ijms21155346"}, {"db": "pmc", "key": "PMC7432786"}], "notes": [], "created": "2020-12-07T16:07:31.972Z", "modified": "2021-02-26T08:45:36.635Z"}, {"entity": "publication", "iuid": "e7c8cb8687554ac194841f84f0afae33", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e7c8cb8687554ac194841f84f0afae33.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e7c8cb8687554ac194841f84f0afae33"}}, "title": "Review of guidelines and recommendations from 17 countries highlights the challenges that clinicians face caring for neonates born to mothers with COVID-19.", "authors": [{"family": "Yeo", "given": "Kee Thai", "initials": "KT"}, {"family": "Oei", "given": "Ju Lee", "initials": "JL"}, {"family": "De Luca", "given": "Daniele", "initials": "D"}, {"family": "Schm\u00f6lzer", "given": "Georg M", "initials": "GM"}, {"family": "Guaran", "given": "Robert", "initials": "R"}, {"family": "Palasanthiran", "given": "Pamela", "initials": "P"}, {"family": "Kumar", "given": "Kishore", "initials": "K"}, {"family": "Buonocore", "given": "Giuseppe", "initials": "G"}, {"family": "Cheong", "given": "Jeanie", "initials": "J"}, {"family": "Owen", "given": "Louise S", "initials": "LS"}, {"family": "Kusuda", "given": "Satoshi", "initials": "S"}, {"family": "James", "given": "Jennifer", "initials": "J"}, {"family": "Lim", "given": "Gina", "initials": "G"}, {"family": "Sharma", "given": "Ankur", "initials": "A"}, {"family": "Uthaya", "given": "Sabita", "initials": "S"}, {"family": "Gale", "given": "Christopher", "initials": "C"}, {"family": "Whittaker", "given": "Elizabeth", "initials": "E"}, {"family": "Battersby", "given": "Cheryl", "initials": "C"}, {"family": "Modi", "given": "Neena", "initials": "N"}, {"family": "Norman", "given": "Mikael", "initials": "M"}, {"family": "Naver", "given": "Lars", "initials": "L"}, {"family": "Giannoni", "given": "Eric", "initials": "E"}, {"family": "Diambomba", "given": "Yenge", "initials": "Y"}, {"family": "Shah", "given": "Prakeshkumar S", "initials": "PS"}, {"family": "Gagliardi", "given": "Luigi", "initials": "L"}, {"family": "Harrison", "given": "Michael", "initials": "M"}, {"family": "Pillay", "given": "Shakti", "initials": "S"}, {"family": "Alburaey", "given": "Abdullah", "initials": "A"}, {"family": "Yuan", "given": "Yuan", "initials": "Y"}, {"family": "Zhang", "given": "Huayan", "initials": "H"}], "type": "journal article", "published": "2020-07-27", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "volume": null, "issue": null, "issn-l": null}, "abstract": "This review examined how applicable national and regional clinical practice guidelines and recommendations for managing neonates born to mothers with COVID-19 mothers were to the evolving pandemic.\n\nA systematic search and review identified 20 guidelines and recommendations that had been published by May 25, 2020. We analysed documents from 17 countries: Australia, Brazil, Canada, China, France, India, Italy, Japan, Saudi Arabia, Singapore, South Africa, South Korea, Spain, Sweden, Switzerland, the UK and the United States.\n\nThe documents were based on expert consensus with limited evidence and were of variable, low methodological rigour. Most did not provide recommendations for delivery methods or managing symptomatic infants. None provided recommendations for post-discharge assimilation of potentially infected infants into the community. The majority encouraged keeping mothers and infants together, subject to infection control measures, but one-third recommended separation. Although breastfeeding or using breastmilk was widely encouraged, two countries specifically prohibited this.\n\nThe guidelines and recommendations for managing infants affected by COVID-19 were of low, variable quality and may be unsustainable. It is important that transmission risks are not increased when new information is incorporated into clinical recommendations. Practice guidelines should emphasise the extent of uncertainty and clearly define gaps in the evidence.", "doi": "10.1111/apa.15495", "pmid": "32716579", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-26T12:17:38.777Z", "modified": "2020-11-30T08:44:14.646Z"}, {"entity": "publication", "iuid": "871f7354d16c4d1ca89d4b422bd909c6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/871f7354d16c4d1ca89d4b422bd909c6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/871f7354d16c4d1ca89d4b422bd909c6"}}, "title": "Efficacy of Corticosteroids in Patients with SARS, MERS and COVID-19: A Systematic Review and Meta-Analysis.", "authors": [{"family": "Lee", "given": "Keum Hwa", "initials": "KH"}, {"family": "Yoon", "given": "Sojung", "initials": "S"}, {"family": "Jeong", "given": "Gwang Hun", "initials": "GH"}, {"family": "Kim", "given": "Jong Yeob", "initials": "JY"}, {"family": "Han", "given": "Young Joo", "initials": "YJ"}, {"family": "Hong", "given": "Sung Hwi", "initials": "SH"}, {"family": "Ryu", "given": "Seohyun", "initials": "S"}, {"family": "Kim", "given": "Jae Seok", "initials": "JS"}, {"family": "Lee", "given": "Jun Young", "initials": "JY"}, {"family": "Yang", "given": "Jae Won", "initials": "JW"}, {"family": "Lee", "given": "Jinhee", "initials": "J"}, {"family": "Solmi", "given": "Marco", "initials": "M"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Jacob", "given": "Louis", "initials": "L"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Smith", "given": "Lee", "initials": "L"}, {"family": "Oh", "given": "Hans", "initials": "H"}, {"family": "Tizaoui", "given": "Kalthoum", "initials": "K"}, {"family": "Cargnin", "given": "Sarah", "initials": "S"}, {"family": "Terrazzino", "given": "Salvatore", "initials": "S"}, {"family": "Ghayda", "given": "Ramy Abou", "initials": "RA"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Shin", "given": "Jae Il", "initials": "JI"}], "type": "journal article", "published": "2020-07-27", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "9", "issue": "8", "issn-l": "2077-0383"}, "abstract": "(1) Background: The use of corticosteroids in critical coronavirus infections, including severe acute respiratory syndrome (SARS), Middle East Respiratory Syndrome (MERS), or Coronavirus disease 2019 (COVID-19), has been controversial. However, a meta-analysis on the efficacy of steroids in treating these coronavirus infections is lacking. (2) Purpose: We assessed a methodological criticism on the quality of previous published meta-analyses and the risk of misleading conclusions with important therapeutic consequences. We also examined the evidence of the efficacy of corticosteroids in reducing mortality in SARS, MERS and COVID-19. (3) Methods: PubMed, MEDLINE, Embase, and Web of Science were used to identify studies published until 25 April 2020, that reported associations between steroid use and mortality in treating SARS/MERS/COVID-19. Two investigators screened and extracted data independently. Searches were restricted to studies on humans, and articles that did not report the exact number of patients in each group or data on mortality were excluded. We calculated odds ratios (ORs) or hazard ratios (HRs) under the fixed- and random-effect model. (4) Results: Eight articles (4051 patients) were eligible for inclusion. Among these selected studies, 3416 patients were diagnosed with SARS, 360 patients with MERS, and 275 with COVID-19; 60.3% patients were administered steroids. The meta-analyses including all studies showed no differences overall in terms of mortality (OR 1.152, 95% CI 0.631-2.101 in the random effects model, p = 0.645). However, this conclusion might be biased, because, in some studies, the patients in the steroid group had more severe symptoms than those in the control group. In contrast, when the meta-analysis was performed restricting only to studies that used appropriate adjustment (e.g., time, disease severity), there was a significant difference between the two groups (HR 0.378, 95% CI 0.221-0.646 in the random effects model, p < 0.0001). Although there was no difference in mortality when steroids were used in severe cases, there was a difference among the group with more underlying diseases (OR 3.133, 95% CI 1.670-5.877, p < 0.001). (5) Conclusions: To our knowledge, this study is the first comprehensive systematic review and meta-analysis providing the most accurate evidence on the effect of steroids in coronavirus infections. If not contraindicated, and in the absence of side effects, the use of steroids should be considered in coronavirus infection including COVID-19.", "doi": "10.3390/jcm9082392", "pmid": "32726951", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jcm9082392"}, {"db": "pmc", "key": "PMC7465945"}], "notes": [], "created": "2020-11-26T12:15:27.760Z", "modified": "2020-11-30T08:44:13.309Z"}, {"entity": "publication", "iuid": "d94b8fd3ab114fbab0ca35902c0364b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d94b8fd3ab114fbab0ca35902c0364b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d94b8fd3ab114fbab0ca35902c0364b3"}}, "title": "Compliance to Recommendations and Mental Health Consequences among Elderly in Sweden during the Initial Phase of the COVID-19 Pandemic-A Cross Sectional Online Survey.", "authors": [{"family": "Gustavsson", "given": "Johanna", "initials": "J"}, {"family": "Beckman", "given": "Linda", "initials": "L"}], "type": "journal article", "published": "2020-07-26", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "15", "pages": "5380"}, "abstract": "Background (1): In the wake of COVID-19, elderly people have been labelled a risk group. As the pandemic is a new crisis in Sweden, we have no knowledge on how this group perceives the information and recommendations being provided. Complying with these recommendations entails physical distancing and, for some, isolation at home. Methods (2): From 16 April to 15 May 2020, we conducted an online survey targeting people aged 70 and older in Sweden (n = 1854). Results (3): A vast majority of the participants find the information and recommendations clear and reliable. Half of the participants report staying at home all the time, and up to half report decreased mental health in terms of, e.g., feeling depressed, having sleeping problems and that isolation makes them feel bad. However, elderly people are not a homogenous group, and there are gender and demographic differences. (4) Conclusion: At this point, we do not know the full extent of the ongoing pandemic, either in terms of duration or in terms of losses. The Swedish model for action on COVID-19 has not included a lock down. However, elderly people seem to comply with recommendations and practice social distancing to a high degree. This might lead to decreased mental health and long-term effects.", "doi": "10.3390/ijerph17155380", "pmid": "32722624", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7432611"}, {"db": "pii", "key": "ijerph17155380"}], "notes": [], "created": "2020-12-07T16:08:58.764Z", "modified": "2023-06-19T14:51:29.461Z"}, {"entity": "publication", "iuid": "237450facd3243e6a1f106b316d527f3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/237450facd3243e6a1f106b316d527f3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/237450facd3243e6a1f106b316d527f3"}}, "title": "Current Status of COVID-19 Therapies and Drug Repositioning Applications.", "authors": [{"family": "Altay", "given": "Ozlem", "initials": "O"}, {"family": "Mohammadi", "given": "Elyas", "initials": "E"}, {"family": "Lam", "given": "Simon", "initials": "S", "orcid": "0000-0002-4476-0971", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89c92490f9c747da8af1c28fc155ac8a.json"}}, {"family": "Turkez", "given": "Hasan", "initials": "H"}, {"family": "Boren", "given": "Jan", "initials": "J"}, {"family": "Nielsen", "given": "Jens", "initials": "J", "orcid": "0000-0002-9955-6003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f4b76d85efe148889e8a33aa78a75c87.json"}}, {"family": "Uhlen", "given": "Mathias", "initials": "M"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb9f5331ce524497923b4d7044bed6a8.json"}}], "type": "journal article", "published": "2020-07-24", "journal": {"title": "iScience", "issn": "2589-0042", "issn-l": "2589-0042", "volume": "23", "issue": "7", "pages": "101303"}, "abstract": "The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19. Drug repositioning is an attractive approach that can facilitate the drug discovery process by repurposing existing pharmaceuticals to treat illnesses other than their primary indications. Here, we review current information concerning the global health issue of COVID-19 including promising approved drugs and ongoing clinical trials for prospective treatment options. In addition, we describe computational approaches to be used in drug repurposing and highlight examples of in silico studies of drug development efforts against SARS-CoV-2.", "doi": "10.1016/j.isci.2020.101303", "pmid": "32622261", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(20)30490-9"}, {"db": "pmc", "key": "PMC7305759"}], "notes": [], "created": "2020-11-04T13:11:37.791Z", "modified": "2021-06-22T13:25:22.943Z"}, {"entity": "publication", "iuid": "7e6dbde8bcd14d81a72d07014d95c74e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e6dbde8bcd14d81a72d07014d95c74e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e6dbde8bcd14d81a72d07014d95c74e"}}, "title": "Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection.", "authors": [{"family": "Messner", "given": "Christoph B", "initials": "CB"}, {"family": "Demichev", "given": "Vadim", "initials": "V"}, {"family": "Wendisch", "given": "Daniel", "initials": "D"}, {"family": "Michalick", "given": "Laura", "initials": "L"}, {"family": "White", "given": "Matthew", "initials": "M"}, {"family": "Freiwald", "given": "Anja", "initials": "A"}, {"family": "Textoris-Taube", "given": "Kathrin", "initials": "K"}, {"family": "Vernardis", "given": "Spyros I", "initials": "SI"}, {"family": "Egger", "given": "Anna-Sophia", "initials": "A"}, {"family": "Kreidl", "given": "Marco", "initials": "M"}, {"family": "Ludwig", "given": "Daniela", "initials": "D"}, {"family": "Kilian", "given": "Christiane", "initials": "C"}, {"family": "Agostini", "given": "Federica", "initials": "F"}, {"family": "Zelezniak", "given": "Aleksej", "initials": "A"}, {"family": "Thibeault", "given": "Charlotte", "initials": "C"}, {"family": "Pfeiffer", "given": "Moritz", "initials": "M"}, {"family": "Hippenstiel", "given": "Stefan", "initials": "S"}, {"family": "Hocke", "given": "Andreas", "initials": "A"}, {"family": "von Kalle", "given": "Christof", "initials": "C"}, {"family": "Campbell", "given": "Archie", "initials": "A"}, {"family": "Hayward", "given": "Caroline", "initials": "C"}, {"family": "Porteous", "given": "David J", "initials": "DJ"}, {"family": "Marioni", "given": "Riccardo E", "initials": "RE"}, {"family": "Langenberg", "given": "Claudia", "initials": "C"}, {"family": "Lilley", "given": "Kathryn S", "initials": "KS"}, {"family": "Kuebler", "given": "Wolfgang M", "initials": "WM"}, {"family": "M\u00fclleder", "given": "Michael", "initials": "M"}, {"family": "Drosten", "given": "Christian", "initials": "C"}, {"family": "Suttorp", "given": "Norbert", "initials": "N"}, {"family": "Witzenrath", "given": "Martin", "initials": "M"}, {"family": "Kurth", "given": "Florian", "initials": "F"}, {"family": "Sander", "given": "Leif Erik", "initials": "LE"}, {"family": "Ralser", "given": "Markus", "initials": "M"}], "type": "journal article", "published": "2020-07-22", "journal": {"title": "Cell Syst", "issn": "2405-4720", "issn-l": null, "volume": "11", "issue": "1", "pages": "11-24.e4"}, "abstract": "The COVID-19 pandemic is an unprecedented global challenge, and point-of-care diagnostic classifiers are urgently required. Here, we present a platform for ultra-high-throughput serum and plasma proteomics that builds on ISO13485 standardization to facilitate simple implementation in regulated clinical laboratories. Our low-cost workflow handles up to 180 samples per day, enables high precision quantification, and reduces batch effects for large-scale and longitudinal studies. We use our platform on samples collected from a cohort of early hospitalized cases of the SARS-CoV-2 pandemic and identify 27 potential biomarkers that are differentially expressed depending on the WHO severity grade of COVID-19. They include complement factors, the coagulation system, inflammation modulators, and pro-inflammatory factors upstream and downstream of interleukin 6. All protocols and software for implementing our approach are freely available. In total, this work supports the development of routine proteomic assays to aid clinical decision making and generate hypotheses about potential COVID-19 therapeutic targets.", "doi": "10.1016/j.cels.2020.05.012", "pmid": "32619549", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Proteins": null, "Category: Serology": null}, "xrefs": [{"db": "pii", "key": "S2405-4712(20)30197-6"}, {"db": "pmc", "key": "PMC7264033"}], "notes": [], "created": "2020-12-08T15:06:05.260Z", "modified": "2022-11-10T07:33:00.728Z"}, {"entity": "publication", "iuid": "ff6f8d98da824a7d8c7ab483aeade546", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff6f8d98da824a7d8c7ab483aeade546.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff6f8d98da824a7d8c7ab483aeade546"}}, "title": "Substance Use Disorders and COVID-19: Multi-Faceted Problems Which Require Multi-Pronged Solutions.", "authors": [{"family": "Jemberie", "given": "Wossenseged Birhane", "initials": "WB"}, {"family": "Stewart Williams", "given": "Jennifer", "initials": "J"}, {"family": "Eriksson", "given": "Malin", "initials": "M"}, {"family": "Gr\u00f6nlund", "given": "Ann-Sofie", "initials": "AS"}, {"family": "Ng", "given": "Nawi", "initials": "N"}, {"family": "Blom Nilsson", "given": "Marcus", "initials": "M"}, {"family": "Padyab", "given": "Mojgan", "initials": "M"}, {"family": "Priest", "given": "Kelsey Caroline", "initials": "KC"}, {"family": "Sandlund", "given": "Mikael", "initials": "M"}, {"family": "Snellman", "given": "Fredrik", "initials": "F"}, {"family": "McCarty", "given": "Dennis", "initials": "D"}, {"family": "Lundgren", "given": "Lena M", "initials": "LM"}], "type": "journal article", "published": "2020-07-21", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "11", "issue": null, "pages": "714", "issn-l": "1664-0640"}, "abstract": "COVID-19 shocked health and economic systems leaving millions of people without employment and safety nets. The pandemic disproportionately affects people with substance use disorders (SUDs) due to the collision between SUDs and COVID-19. Comorbidities and risk environments for SUDs are likely risk factors for COVID-19. The pandemic, in turn, diminishes resources that people with SUD need for their recovery and well-being. This article presents an interdisciplinary and international perspective on how COVID-19 and the related systemic shock impact on individuals with SUDs directly and indirectly. We highlight a need to understand SUDs as biopsychosocial disorders and use evidence-based policies to destigmatize SUDs. We recommend a suite of multi-sectorial actions and strategies to strengthen, modernize and complement addiction care systems which will become resilient and responsive to future systemic shocks similar to the COVID-19 pandemic.", "doi": "10.3389/fpsyt.2020.00714", "pmid": "32848907", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7396653"}], "notes": [], "created": "2020-12-07T10:23:23.099Z", "modified": "2020-12-07T10:23:40.294Z"}, {"entity": "publication", "iuid": "10054aad3a5c4b87aef56f880a53e7d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/10054aad3a5c4b87aef56f880a53e7d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/10054aad3a5c4b87aef56f880a53e7d5"}}, "title": "Non-Bacterial Thrombotic Endocarditis: A Presentation of COVID-19.", "authors": [{"family": "Balata", "given": "Dilan", "initials": "D"}, {"family": "Mellerg\u00e5rd", "given": "Johan", "initials": "J"}, {"family": "Ekqvist", "given": "David", "initials": "D"}, {"family": "Baranowski", "given": "Jacek", "initials": "J"}, {"family": "Garcia", "given": "Isidro Albert", "initials": "IA"}, {"family": "Volosyraki", "given": "Marina", "initials": "M"}, {"family": "Broqvist", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2020-07-21", "journal": {"title": "Eur J Case Rep Intern Med", "issn": "2284-2594", "volume": "7", "issue": "8", "pages": "001811", "issn-l": null}, "abstract": "The SARS-CoV-2 virus is a newly emergent pathogen first identified in Wuhan, China, and responsible for the COVID-19 global pandemic. In this case report we describe a manifestation of non-bacterial thrombotic endocarditis with continuous peripheral embolization in a COVID-19-positive patient. The patient responded well to high-dose LMWH treatment with cessation of the embolic process.\n\nRaising awareness of possible complications of COVID-19.To highlight the importance of the careful consideration of and dosage of anticoagulation in non-bacterial thrombotic endocarditis.", "doi": "10.12890/2020_001811", "pmid": "32789144", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "1811-1-15256-1-10-20200720"}, {"db": "pmc", "key": "PMC7417053"}], "notes": [], "created": "2020-12-07T13:26:39.296Z", "modified": "2020-12-07T13:26:52.483Z"}, {"entity": "publication", "iuid": "f7fa3b5f385f4911885bc7374541634f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7fa3b5f385f4911885bc7374541634f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7fa3b5f385f4911885bc7374541634f"}}, "title": "Multidisciplinary Tracheostomy Quality Improvement in the COVID-19 Pandemic: Building a Global Learning Community.", "authors": [{"family": "Swords", "given": "Chloe", "initials": "C"}, {"family": "Bergman", "given": "Lina", "initials": "L"}, {"family": "Wilson-Jeffers", "given": "Rachel", "initials": "R"}, {"family": "Randall", "given": "Diane", "initials": "D"}, {"family": "Morris", "given": "Linda L", "initials": "LL"}, {"family": "Brenner", "given": "Michael J", "initials": "MJ"}, {"family": "Arora", "given": "Asit", "initials": "A"}], "type": "journal article", "published": "2020-07-17", "journal": {"title": "Ann Otol Rhinol Laryngol", "issn": "1943-572X", "volume": null, "issue": null, "pages": "3489420941542", "issn-l": null}, "abstract": "To report experience with a global multidisciplinary tracheostomy e-learning initiative.\n\nAn international multidisciplinary panel of experts convened to build a virtual learning community for tracheostomy care, comprising a web-based platform, five distance learning (interactive webinar) sessions, and professional discourse over 12 months. Structured pre- and post-webinar surveys were disseminated to global participants including otolaryngologists, intensivists, nurses, allied health professionals, and patients/caregivers. Data were collected on audio-visual fidelity, demographics, and pre- and post-tutorial assessments regarding experience and skill acquisition. Participants reported confidence levels for NICU, pediatric, adult, and family care, as well as technical skills, communication, learning, assessment, and subdomains.\n\nParticipants from 197 institutions in 22 countries engaged in the virtual education platform, including otolaryngologists, speech pathologists, respiratory therapists, specialist nurses, patients, and caregivers. Significant improvements were reported in communication ( P < .0001), clinical assessments (P < .0001), and clinical governance (P < .0001), with positive impact on pediatric decannulation (P = .0008), adult decannulation (P = .04), and quality improvement (P < .0001). Respondents reported enhanced readiness to integrate knowledge into practice. Barriers included time zones, internet bandwidth, and perceived difficulty of direct clinical translation of highly technical skills. Participants rated the implementation highly in terms of length, ability for discussion, satisfaction, applicability to professional practice, and expertise of discussants (median scores: 4, 4, 4, 4 and 5 out of 5).\n\nVirtual learning has dominated the education landscape during COVID-19 pandemic, but few data are available on its effectiveness. This study demonstrated feasibility of virtual learning for disseminating best practices in tracheostomy, engaging a diverse, multidisciplinary audience. Learning of complex technical skills proved a hurdle, however, suggesting need for hands-on experience for technical mastery. While interactive videoconferencing via webinar affords an engaging and scalable strategy for sharing knowledge, further investigation is needed on clinical outcomes to define effective strategies for experiential online learning and virtual in-service simulations.", "doi": "10.1177/0003489420941542", "pmid": "32680435", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7369399"}], "notes": [], "created": "2020-12-07T16:32:06.801Z", "modified": "2020-12-07T16:33:54.718Z"}, {"entity": "publication", "iuid": "1d34255c1b8d4bde8b603828a8fc2bc8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d34255c1b8d4bde8b603828a8fc2bc8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d34255c1b8d4bde8b603828a8fc2bc8"}}, "title": "Role of Environmental Temperature on the Attack rate and Case fatality rate of Coronavirus Disease 2019 (COVID-19) Pandemic.", "authors": [{"family": "Hassan", "given": "Mohammad M", "initials": "MM"}, {"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME"}, {"family": "Khan", "given": "Shahneaz A", "initials": "SA"}, {"family": "Islam", "given": "Ariful", "initials": "A"}, {"family": "Nayem", "given": "Md Raihan K", "initials": "MRK"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}], "type": "journal article", "published": "2020-07-16", "journal": {"title": "Infect Ecol Epidemiol", "issn": "2000-8686", "volume": "10", "issue": "1", "pages": "1792620", "issn-l": "2000-8686"}, "abstract": "SARS-CoV-2 is a zoonotic Betacoronavirus causing the devastating COVID-19 pandemic. More than twelve million COVID-19 cases and 500 thousand fatalities have been reported in 216 countries. Although SARS-CoV-2 originated in China, comparatively fewer people have been affected in other Asian countries than in Europe and the USA. This study examined the hypothesis that lower temperature may increase the spread of SARS-CoV-2 by comparing attack rate and case fatality rate (until 21 March 2020) to mean temperature in January-February 2020. The attack rate was highest in Luxembourg followed by Italy and Switzerland. There was a significant (p = 0.02) correlation between decreased attack rate and increased environmental temperature. The case fatality rate was highest in Italy followed by Iran and Spain. There was no significant correlation between the case fatality rate and temperature. This study indicates that lower temperature may increase SARS-CoV-2 transmission (measured as an increased attack rate), but there is no evidence that temperature affects the severity of the disease (measured as case fatality rate). However, there are clearly other factors that affect the transmission of SARS-CoV-2, and many of these may be sensitive to interventions, e.g. through increased public awareness and public health response.", "doi": "10.1080/20008686.2020.1792620", "pmid": "32944163", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "1792620"}, {"db": "pmc", "key": "PMC7480504"}], "notes": [], "created": "2020-11-18T17:34:57.249Z", "modified": "2021-02-26T08:46:12.968Z"}, {"entity": "publication", "iuid": "c23bcab33a00461ca27d92a08ead96cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c23bcab33a00461ca27d92a08ead96cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c23bcab33a00461ca27d92a08ead96cf"}}, "title": "Repurposing CD8 + T cell immunity against SARS-CoV-2 for cancer immunotherapy: a positive aspect of the COVID-19 pandemic?", "authors": [{"family": "Gujar", "given": "Shashi", "initials": "S"}, {"family": "Pol", "given": "Jonathan G", "initials": "JG"}, {"family": "Kim", "given": "Youra", "initials": "Y"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}], "type": "journal article", "published": "2020-07-16", "journal": {"title": "Oncoimmunology", "issn": "2162-4011", "volume": "9", "issue": "1", "pages": "1794424", "issn-l": null}, "abstract": "The COVID-19 pandemic has afflicted most countries on the planet. As a result, immunity against SARS-CoV-2, induced via natural infections or imminent vaccinations, is expected to develop in a large fraction of the global population. Here, we propose to exploit SARS-CoV-2-specific CD8 + T cells for cancer immunotherapy strategies.", "doi": "10.1080/2162402X.2020.1794424", "pmid": "32923158", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "1794424"}, {"db": "pmc", "key": "PMC7458627"}], "notes": [], "created": "2020-11-26T12:31:06.390Z", "modified": "2020-11-26T12:31:06.401Z"}, {"entity": "publication", "iuid": "19037d975bdc46d69a046a10002818f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19037d975bdc46d69a046a10002818f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19037d975bdc46d69a046a10002818f0"}}, "title": "Effect of statins on SARS-CoV-2 infection", "authors": [{"family": "Moeller", "given": "Rebecca", "initials": "R"}, {"family": "Zapatero-Belinch\u00f3n", "given": "Francisco J", "initials": "FJ"}, {"family": "Lasswitz", "given": "Lisa", "initials": "L"}, {"family": "Kirui", "given": "Jared", "initials": "J"}, {"family": "Brogden", "given": "Graham", "initials": "G"}, {"family": "Gunesch", "given": "Antonia P", "initials": "AP"}, {"family": "Pietschmann", "given": "Thomas", "initials": "T"}, {"family": "Wichmann", "given": "Dominic", "initials": "D"}, {"family": "Kluge", "given": "Stefan", "initials": "S"}, {"family": "Gerold", "given": "Gisa", "initials": "G", "orcid": "0000-0002-1326-5038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39af3df98cf14f96baa155798617841b.json"}}], "type": "posted-content", "published": "2020-07-14", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.07.13.20152272", "pmid": null, "labels": {"Funder: KAW/SciLifeLab": null, "Type: Preprint": null, "Research Area: Host cell systems biology and targets": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-15T16:41:57.170Z", "modified": "2022-11-22T05:52:24.479Z"}, {"entity": "publication", "iuid": "61c4d6c1a504486f9ab36320ec38bdd3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61c4d6c1a504486f9ab36320ec38bdd3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61c4d6c1a504486f9ab36320ec38bdd3"}}, "title": "Discriminative Bayesian Serology: Counting Without Cutoffs", "authors": [{"family": "Christian", "given": "Murray", "initials": "M"}, {"family": "Murrell", "given": "Ben", "initials": "B", "orcid": "0000-0002-0393-4445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60dac9ecf84d4eb3b90fb4ee1298bc52.json"}}], "type": "posted-content", "published": "2020-07-14", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.07.14.202150", "pmid": null, "labels": {"Type: Preprint": null, "Funder: H2020": null, "Category: Other": null, "Category: Serology": null}, "xrefs": [], "notes": [], "created": "2021-01-08T09:00:29.416Z", "modified": "2022-11-10T07:33:32.183Z"}, {"entity": "publication", "iuid": "e541e41eb72f48c6989a921a797b6bd8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e541e41eb72f48c6989a921a797b6bd8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e541e41eb72f48c6989a921a797b6bd8"}}, "title": "Covid-19: an opportunity to reduce unnecessary healthcare.", "authors": [{"family": "Moynihan", "given": "Ray", "initials": "R"}, {"family": "Johansson", "given": "Minna", "initials": "M"}, {"family": "Maybee", "given": "Alies", "initials": "A"}, {"family": "Lang", "given": "Eddy", "initials": "E"}, {"family": "L\u00e9gar\u00e9", "given": "France", "initials": "F"}], "type": "editorial", "published": "2020-07-14", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "370", "issue": null, "pages": "m2752", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m2752", "pmid": "32665257", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-08T10:41:40.545Z", "modified": "2020-12-08T10:41:40.554Z"}, {"entity": "publication", "iuid": "14a924a1edb949dc91ae4e6f9e35714c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/14a924a1edb949dc91ae4e6f9e35714c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/14a924a1edb949dc91ae4e6f9e35714c"}}, "title": "An immunotherapeutic method for COVID-19 patients: a soluble ACE2-Anti-CD16 VHH to block SARS-CoV-2 Spike protein.", "authors": [{"family": "Sheikhi", "given": "Abdolkarim", "initials": "A"}, {"family": "Hojjat-Farsangi", "given": "Mohammad", "initials": "M"}], "type": "journal article", "published": "2020-07-14", "journal": {"title": "Hum Vaccin Immunother", "issn": "2164-554X", "issn-l": null, "volume": null, "issue": null, "pages": "1-6"}, "abstract": "The third outbreak of coronavirus (CoV) infection (after SARS-CoV and MERS-CoV) caused by a novel CoV (SARS-CoV-2) of the genus Beta-coronavirus has become a global pandemic. CoVs are enveloped viruses whose proteins include spike (S), membrane (M), and envelope (E) which are embedded in the viral envelope. The glycosylated S protein, which forms homo-trimeric spikes on the surface of the viral particle, mediates viral entry into host cells. SARS-CoV-2, like SARS-CoV, uses the Angiotensin-Converting Enzyme 2 (ACE2) cell surface protein for cellular entry. An attractive anti-viral approach is targeting virus entry into cells, for which three strategies are suggested: 1) direct targeting of the viral glycoprotein; 2) targeting the viral receptor on the cell surface; and 3) using soluble (s) ACE2 that binds to S protein thereby neutralizing the virus. In this article, the advantages and disadvantages of these strategies are explained. Moreover, we propose that fusion of the sACE2 to anti-CD16 to produce a bi-speci\ufb01c molecule could be a promising anti-viral strategy.", "doi": "10.1080/21645515.2020.1787066", "pmid": "32663051", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-08T10:42:25.787Z", "modified": "2020-12-08T10:42:53.471Z"}, {"entity": "publication", "iuid": "097a76b78d194ee4b04ef819bfdb543c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/097a76b78d194ee4b04ef819bfdb543c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/097a76b78d194ee4b04ef819bfdb543c"}}, "title": "Misinformation and de-contextualization: international media reporting on Sweden and COVID-19.", "authors": [{"family": "Irwin", "given": "Rachel Elisabeth", "initials": "RE"}], "type": "journal article", "published": "2020-07-13", "journal": {"title": "Global Health", "issn": "1744-8603", "volume": "16", "issue": "1", "pages": "62", "issn-l": "1744-8603"}, "abstract": "In the first month of the 2020 COVID-19 pandemic, Sweden took the same strategy as most other countries, working to \"flatten the curve,\" by slowing transmission so that the healthcare system could cope with the disease. However, unlike most other countries, much of Sweden's implementation focused on voluntary and stepwise action, rather than legislation and compulsory measures, leading to considerable attention in the international media.Six main narratives emerged in the international media reporting on Sweden during the first month of the COVID-19 pandemic: (1) Life is normal in Sweden, (2) Sweden has a herd immunity strategy, (3) Sweden is not following expert advice, (4) Sweden is not following WHO recommendations (5) the Swedish approach is failing and (6) Swedes trust the government. While these narratives are partially grounded in reality, in some media outlets, the language and examples used to frame the story distorted the accuracy of the reporting.This debate examines the ways in which international media both constructs and represents a pandemic, and the implications for how researchers engage with news and social media. Cross-country comparison and the sharing of best practice are reliant on accurate information. The Swedish example underlines the importance of fact checking and source critique and the need for precision when presenting data and statistics. It also highlights limitations of using culture as an explanation for behavior, and the pitfalls of evaluating policy during a pandemic.", "doi": "10.1186/s12992-020-00588-x", "pmid": "32660503", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12992-020-00588-x"}, {"db": "pmc", "key": "PMC7356107"}], "notes": [], "created": "2020-12-08T10:44:40.041Z", "modified": "2020-12-08T10:44:40.049Z"}, {"entity": "publication", "iuid": "01e9b6b57731417a9927d1ad9f5d4027", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01e9b6b57731417a9927d1ad9f5d4027.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01e9b6b57731417a9927d1ad9f5d4027"}}, "title": "Effects of COVID-19 on Plastic Surgery Practices and Medi-Spas in Different Countries.", "authors": [{"family": "Montemurro", "given": "Paolo", "initials": "P"}, {"family": "Hed\u00e9n", "given": "Per", "initials": "P"}, {"family": "Adams", "given": "William P", "initials": "WP"}, {"family": "de Vita", "given": "Roy", "initials": "R"}, {"family": "Pellegatta", "given": "Tommaso", "initials": "T"}], "type": "letter", "published": "2020-07-13", "journal": {"title": "Aesthet Surg J", "issn": "1527-330X", "volume": "40", "issue": "8", "pages": "N453-N456", "issn-l": null}, "abstract": null, "doi": "10.1093/asj/sjaa104", "pmid": "32495819", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5851306"}, {"db": "pmc", "key": "PMC7314219"}], "notes": [], "created": "2020-12-09T10:48:40.042Z", "modified": "2020-12-09T10:48:40.065Z"}, {"entity": "publication", "iuid": "a1107310294e40e8886c613539a3151b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a1107310294e40e8886c613539a3151b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a1107310294e40e8886c613539a3151b"}}, "title": "The link between vitamin D and COVID-19: distinguishing facts from fiction.", "authors": [{"family": "Bergman", "given": "P", "initials": "P"}], "type": "editorial", "published": "2020-07-11", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1111/joim.13158", "pmid": "32652766", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7405052"}], "notes": [], "created": "2020-12-08T14:17:01.925Z", "modified": "2020-12-08T14:17:01.938Z"}, {"entity": "publication", "iuid": "0ffc406108044dabb325c6ff9858e0ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ffc406108044dabb325c6ff9858e0ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ffc406108044dabb325c6ff9858e0ae"}}, "title": "Psychometric Testing of Three COVID-19-Related Scales Among People with Mental Illness.", "authors": [{"family": "Chang", "given": "Kun-Chia", "initials": "KC"}, {"family": "Hou", "given": "Wen-Li", "initials": "WL"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}], "type": "journal article", "published": "2020-07-11", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "volume": null, "issue": null, "pages": "1-13", "issn-l": null}, "abstract": "Fear of novel coronavirus 2019 (COVID-19) may result in psychological health problems among different populations. Moreover, believing COVID-19 information and preventive COVID-19 infection behaviors are relevant constructs associated with fear of COVID-19. Therefore, the present study validated three instruments assessing fear, beliefs, and preventive behaviors related to COVID-19 among individuals with mental illness. Moreover, relationships between the three constructs were examined. Individuals with mental illness ( N = 400; 178 females; mean age = 46.91 years) completed the Fear of COVID-19 Scale (FCV-19S), Believing COVID-19 Information Scale (BCIS), Preventive COVID-19 Infection Behaviors Scale (PCIBS), and Depression Anxiety Stress Scale-21 (DASS-21). The FCV-19S, BCIS, and PCIBS demonstrated a single-factor structure with satisfactory fit indices. Moreover, believing COVID-19 information positively and significantly associated with fear of COVID-19, and fear of COVID-19 negatively and significantly associated with preventive behaviors and positively and significantly associated with psychological distress. The FCV-19S, BCIS, and PCIBS may assist healthcare providers in assessing COVID-19-related information among individuals with mental illness. Consequently, relevant programs may be designed to help individuals with mental illness going through the period of crisis.", "doi": "10.1007/s11469-020-00361-6", "pmid": "32837442", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "361"}, {"db": "pmc", "key": "PMC7354353"}], "notes": [], "created": "2020-12-07T10:34:46.665Z", "modified": "2021-02-26T08:45:47.848Z"}, {"entity": "publication", "iuid": "4d025e959931413b8de13ebe37146358", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4d025e959931413b8de13ebe37146358.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4d025e959931413b8de13ebe37146358"}}, "title": "Economic, Mental Health, HIV Prevention and HIV Treatment Impacts of COVID-19 and the COVID-19 Response on a Global Sample of Cisgender Gay Men and Other Men Who Have Sex with Men.", "authors": [{"family": "Santos", "given": "Glenn-Milo", "initials": "G"}, {"family": "Ackerman", "given": "Benjamin", "initials": "B"}, {"family": "Rao", "given": "Amrita", "initials": "A"}, {"family": "Wallach", "given": "Sara", "initials": "S"}, {"family": "Ayala", "given": "George", "initials": "G"}, {"family": "Lamontage", "given": "Erik", "initials": "E"}, {"family": "Garner", "given": "Alex", "initials": "A"}, {"family": "Holloway", "given": "Ian W", "initials": "IW"}, {"family": "Arreola", "given": "Sonya", "initials": "S"}, {"family": "Silenzio", "given": "Vince", "initials": "V"}, {"family": "Str\u00f6mdahl", "given": "Susanne", "initials": "S"}, {"family": "Yu", "given": "Louis", "initials": "L"}, {"family": "Strong", "given": "Carol", "initials": "C"}, {"family": "Adamson", "given": "Tyler", "initials": "T"}, {"family": "Yakusik", "given": "Anna", "initials": "A"}, {"family": "Doan", "given": "Tran Thu", "initials": "TT"}, {"family": "Huang", "given": "Poyao", "initials": "P"}, {"family": "Cerasuolo", "given": "Damiano", "initials": "D"}, {"family": "Bishop", "given": "Amie", "initials": "A"}, {"family": "Noori", "given": "Teymur", "initials": "T"}, {"family": "Pharris", "given": "Anastasia", "initials": "A"}, {"family": "Aung", "given": "Max", "initials": "M"}, {"family": "Dara", "given": "Masoud", "initials": "M"}, {"family": "Chung", "given": "Ssu Yu", "initials": "SY"}, {"family": "Hanley", "given": "Marguerite", "initials": "M"}, {"family": "Baral", "given": "Stefan", "initials": "S"}, {"family": "Beyrer", "given": "Chris", "initials": "C"}, {"family": "Howell", "given": "Sean", "initials": "S"}], "type": "journal article", "published": "2020-07-11", "journal": {"title": "AIDS Behav", "issn": "1573-3254", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "There is an urgent need to measure the impacts of COVID-19 among gay men and other men who have sex with men (MSM). We conducted a cross-sectional survey with a global sample of gay men and other MSM (n = 2732) from April 16, 2020 to May 4, 2020, through a social networking app. We characterized the economic, mental health, HIV prevention and HIV treatment impacts of COVID-19 and the COVID-19 response, and examined whether sub-groups of our study population are disproportionately impacted by COVID-19. Many gay men and other MSM not only reported economic and mental health consequences, but also interruptions to HIV prevention and testing, and HIV care and treatment services. These consequences were significantly greater among people living with HIV, racial/ethnic minorities, immigrants, sex workers, and socio-economically disadvantaged groups. These findings highlight the urgent need to mitigate the negative impacts of COVID-19 among gay men and other MSM.", "doi": "10.1007/s10461-020-02969-0", "pmid": "32654021", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10461-020-02969-0"}, {"db": "pmc", "key": "PMC7352092"}], "notes": [], "created": "2020-12-08T14:16:22.309Z", "modified": "2022-11-10T07:36:53.488Z"}, {"entity": "publication", "iuid": "b47287449a85462a81f301754bf0fea5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b47287449a85462a81f301754bf0fea5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b47287449a85462a81f301754bf0fea5"}}, "title": "Development and Validation of a Nomogram for Assessing Survival in Patients with COVID-19 Pneumonia.", "authors": [{"family": "Dong", "given": "Yi-Min", "initials": "YM"}, {"family": "Sun", "given": "Jia", "initials": "J"}, {"family": "Li", "given": "Yi-Xin", "initials": "YX"}, {"family": "Chen", "given": "Qian", "initials": "Q"}, {"family": "Liu", "given": "Qing-Quan", "initials": "QQ"}, {"family": "Sun", "given": "Zhou", "initials": "Z"}, {"family": "Pang", "given": "Ran", "initials": "R"}, {"family": "Chen", "given": "Fei", "initials": "F"}, {"family": "Xu", "given": "Bing-Yang", "initials": "BY"}, {"family": "Manyande", "given": "Anne", "initials": "A"}, {"family": "Clark", "given": "Taane G", "initials": "TG"}, {"family": "Li", "given": "Jin-Ping", "initials": "JP"}, {"family": "Orhan", "given": "Ilkay Erdogan", "initials": "IE"}, {"family": "Tian", "given": "Yu-Ke", "initials": "YK"}, {"family": "Wang", "given": "Tao", "initials": "T"}, {"family": "Wu", "given": "Wei", "initials": "W"}, {"family": "Ye", "given": "Da-Wei", "initials": "DW"}], "type": "journal article", "published": "2020-07-10", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "volume": null, "issue": null, "issn-l": "1058-4838"}, "abstract": "The outbreak of coronavirus disease (COVID-19) in 2019 has spread worldwide and continues to cause great threat to peoples' health as well as put pressure on the accessibility of medical systems. Early prediction of survival of hospitalized patients will help the clinical management of COVID-19, but such a prediction model which is reliable and valid is still lacking.\n\nWe retrospectively enrolled 628 confirmed cases of COVID-19 using positive RT-PCR tests for SARS-CoV-2 in Tongji Hospital in Wuhan, China. These patients were randomly grouped into a training cohort (60%) and a validation cohort (40%). In the training cohort, least absolute shrinkage and selection operator (LASSO) regression analysis and multivariate Cox regression analysis were utilized to identify prognostic factors for in-hospital survival of patients with COVID-19. A nomogram based on the three variables was built for clinical use. Areas under the ROC curves (AUC), concordance index (C-index) and calibration curve were used to evaluate the efficiency of the nomogram in both the training and validation cohorts.\n\nHypertension, higher neutrophil-to-lymphocyte ratio and increased NT-proBNP value were found to be significantly associated with poorer prognosis in hospitalized patients with COVID-19. The three predictors were further used to build a prediction nomogram. The C-index of the nomogram in the training and validation cohorts was 0.901 and 0.892, respectively. The AUC in the training cohort was 0.922 for 14- day and 0.919 for 21-day probability of in-hospital survival, while in the validation cohort was 0.922 and 0.881, respectively. Moreover, the calibration curve for 14- day and 21-day survival also showed high coherence between the predicted and actual probability of survival.\n\nWe managed to build a predictive model and constructed a nomogram for predicting in-hospital survival of patients with COVID-19. This model represents good performance and might be utilized clinically in the management of COVID-19.", "doi": "10.1093/cid/ciaa963", "pmid": "32649738", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "5869870"}, {"db": "pmc", "key": "PMC7454485"}], "notes": [], "created": "2020-11-19T14:39:34.744Z", "modified": "2021-02-26T08:46:13.460Z"}, {"entity": "publication", "iuid": "4038c04031e8472e973982d27d5b596c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4038c04031e8472e973982d27d5b596c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4038c04031e8472e973982d27d5b596c"}}, "title": "Trauma-informed responses in addressing public mental health consequences of the COVID-19 pandemic: position paper of the European Society for Traumatic Stress Studies (ESTSS).", "authors": [{"family": "Javakhishvili", "given": "Jana Darejan", "initials": "JD"}, {"family": "Ardino", "given": "Vittoria", "initials": "V"}, {"family": "Bragesj\u00f6", "given": "Maria", "initials": "M"}, {"family": "Kazlauskas", "given": "Evaldas", "initials": "E"}, {"family": "Olff", "given": "Miranda", "initials": "M"}, {"family": "Sch\u00e4fer", "given": "Ingo", "initials": "I"}], "type": "journal article", "published": "2020-07-09", "journal": {"title": "Eur J Psychotraumatol", "issn": "2000-8066", "volume": "11", "issue": "1", "pages": "1780782", "issn-l": null}, "abstract": "The COVID-19 pandemic has changed life in Europe and globally. The pandemic affects both individuals and the broader society across many domains, including physical and psychological health, the economy and general welfare. The measures taken to counteract the pandemic have significantly altered daily life and, along with the threat of contracting the coronavirus and uncertainties surrounding future developments, created a complex system of stressors with a negative impact on public mental health. This paper aims to outline the ESTSS strategy to address mental health issues related to COVID-19 and focuses on (1) trauma-informed policies, (2) capacity building, (3) collaborative research and (4) knowledge-exchange. To facilitate implementation of a trauma-informed approach and appropriate measures, ESTSS has developed a toolkit of recommendations on mental health and psychosocial assistance to be provided during the different phases of crisis and its aftermath. To promote capacity building, ESTSS offers a certification programme based on a curriculum in psychotraumatology and corresponding on-line training to the European community of mental health professionals. To assure evidence-based approaches and methods tailored to current circumstances, ESTSS has initiated a pan-European research project with international cooperation aimed at studying the mental health consequences of the pandemic, with a focus on psychological trauma and other stress-related reactions. To foster knowledge-exchange, the European Journal of Psychotraumatology (EJPT), the official journal of ESTSS, is publishing a special issue on COVID-19.", "doi": "10.1080/20008198.2020.1780782", "pmid": "33029320", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "1780782"}, {"db": "pmc", "key": "PMC7473312"}], "notes": [], "created": "2020-12-01T17:34:45.142Z", "modified": "2020-12-01T17:34:45.155Z"}, {"entity": "publication", "iuid": "a63ed59e45d94da1911ac1a678510612", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a63ed59e45d94da1911ac1a678510612.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a63ed59e45d94da1911ac1a678510612"}}, "title": "In the Name of COVID-19: Is the ECB Fuelling the Climate Crisis?", "authors": [{"family": "Cojoianu", "given": "T F", "initials": "TF"}, {"family": "Collins", "given": "E", "initials": "E"}, {"family": "Hoepner", "given": "A G F", "initials": "AGF"}, {"family": "Magill", "given": "D", "initials": "D"}, {"family": "O'Neill", "given": "T", "initials": "T"}, {"family": "Schneider", "given": "F I", "initials": "FI"}], "type": "journal article", "published": "2020-07-09", "journal": {"title": "Environ Resour Econ (Dordr)", "issn": "0924-6460", "volume": null, "issue": null, "pages": "1-7", "issn-l": null}, "abstract": "We offer preliminary evidence drawing on a novel dataset of corporate bonds issued in the European energy sector since January 2020 in combination with the European Central Bank's (ECB) purchases under the Pandemic Emergency Purchase Programme (PEPP) in response to COVID-19. We show that the likelihood of a European energy company bond to be bought as part of the ECB's programme increases with the greenhouse gas (GHG) intensity of the bond issuing firm. We also find weaker evidence that the ECB's PEPP portfolio during the pandemic is likely to become tilted towards companies with anti-climate lobbying activities and companies with less transparent GHG emissions disclosure. Our findings imply that, at later stages of the COVID-19 recovery, an in-depth analysis may be necessary to understand if, and if yes why, the ECB fuelled the climate crisis.", "doi": "10.1007/s10640-020-00450-z", "pmid": "32836830", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "450"}, {"db": "pmc", "key": "PMC7343577"}], "notes": [], "created": "2020-12-07T10:39:12.359Z", "modified": "2020-12-07T10:39:12.371Z"}, {"entity": "publication", "iuid": "68675153e8e349be9fbde1c8a97ed2a5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68675153e8e349be9fbde1c8a97ed2a5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68675153e8e349be9fbde1c8a97ed2a5"}}, "title": "How Medical Studies in Poland Prepare Future Healthcare Managers for Crises and Disasters: Results of a Pilot Study.", "authors": [{"family": "Misztal-Oko\u0144ska", "given": "Patrycja", "initials": "P"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}, {"family": "Hertelendy", "given": "Attila J", "initials": "AJ"}, {"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}, {"family": "Al-Wathinani", "given": "Ahmed", "initials": "A"}, {"family": "Alhazmi", "given": "Riyadh A", "initials": "RA"}, {"family": "Goniewicz", "given": "Mariusz", "initials": "M"}], "type": "journal article", "published": "2020-07-09", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "issn-l": null, "volume": "8", "issue": "3", "pages": null}, "abstract": "In the event of a crisis, rapid and effective assistance for victims is essential, and in many cases, medical assistance is required. To manage the situation efficiently, it is necessary to have a proactive management system in place that ensures professional assistance to victims and the safety of medical personnel. We evaluated the perceptions of students and graduates in public health studies at the Medical University of Lublin, Poland, concerning their preparation and management skills for crises such as the COVID-19 pandemic. This pilot study was conducted in March 2020; we employed an online survey with an anonymous questionnaire that was addressed to students and graduates with an educational focus in healthcare organization and management. The study involved 55 people, including 14 men and 41 women. Among the respondents, 41.8% currently worked in a healthcare facility and only 21.7% of them had participated in training related to preparation for emergencies and disasters in their current workplace. The respondents rated their workplaces' preparedness for the COVID-19 pandemic at four points. A significant number of respondents stated that if they had to manage a public health emergency, they would not be able to manage the situation correctly and not be able to predict its development. Managers of healthcare organizations should have the knowledge and skills to manage crises. It would be advisable for them to have been formally educated in public health or healthcare administration. In every healthcare facility, it is essential that training and practice of performing medical procedures in full personal protective equipment (PPE) be provided. Healthcare facilities must implement regular training combined with practical live scenario exercises to prepare for future crises.", "doi": "10.3390/healthcare8030202", "pmid": "32659897", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "healthcare8030202"}, {"db": "pmc", "key": "PMC7551878"}], "notes": [], "created": "2020-12-08T10:45:49.117Z", "modified": "2022-11-10T07:38:24.769Z"}, {"entity": "publication", "iuid": "6530aa23a91f405dab1dffe84e6082a7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6530aa23a91f405dab1dffe84e6082a7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6530aa23a91f405dab1dffe84e6082a7"}}, "title": "Female Faculty: Why So Few and Why Care?", "authors": [{"family": "Kamerlin", "given": "Shina Caroline Lynn", "initials": "SCL"}, {"family": "Wittung-Stafshede", "given": "Pernilla", "initials": "P"}], "type": "journal article", "published": "2020-07-08", "journal": {"title": "Chemistry", "issn": "1521-3765", "volume": "26", "issue": "38", "pages": "8319-8323", "issn-l": null}, "abstract": "Despite slow ongoing progress in increasing the representation of women in academia, women remain significantly under-represented at senior levels, in particular in the natural sciences and engineering. Not infrequently, this is downplayed by bringing forth arguments such as inherent biological differences between genders, that current policies are adequate to address the issue, or by deflecting this as being \"not my problem\" among other examples. In this piece we present scientific evidence that counters these claims, as well as a best-practice example, Genie, from Chalmers University of Technology, where one of the authors is currently employed. We also highlight particular challenges caused by the current COVID-19 pandemic. Finally, we conclude by proposing some possible solutions to the situation and emphasize that we need to all do our part, to ensure that the next generation of academics experience a more diverse, inclusive, and equitable working environment.", "doi": "10.1002/chem.202002522", "pmid": "32583921", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-08T15:52:50.109Z", "modified": "2020-12-08T15:52:50.134Z"}, {"entity": "publication", "iuid": "65e3364e9e5d4f9a8a2d4ff3daef5d7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65e3364e9e5d4f9a8a2d4ff3daef5d7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65e3364e9e5d4f9a8a2d4ff3daef5d7a"}}, "title": "Conspiracy Beliefs Are Associated with Lower Knowledge and Higher Anxiety Levels Regarding COVID-19 among Students at the University of Jordan.", "authors": [{"family": "Sallam", "given": "Malik", "initials": "M"}, {"family": "Dababseh", "given": "Deema", "initials": "D"}, {"family": "Yaseen", "given": "Alaa'", "initials": "A"}, {"family": "Al-Haidar", "given": "Ayat", "initials": "A"}, {"family": "Ababneh", "given": "Nidaa A", "initials": "NA"}, {"family": "Bakri", "given": "Faris G", "initials": "FG"}, {"family": "Mahafzah", "given": "Azmi", "initials": "A"}], "type": "journal article", "published": "2020-07-08", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "14", "pages": null}, "abstract": "The world has been afflicted heavily by the burden of coronavirus disease 2019 (COVID-19) that overwhelmed health care systems and caused severe economic and educational deficits, in addition to anxiety among the public. The main aim of this study was to evaluate the mutual effects of belief that the pandemic was the result of a conspiracy on knowledge and anxiety levels among students at the University of Jordan (UJ). An electronic-based survey was conducted between 29 March, 2020 and 31 March, 2020. The targeted population involved all undergraduate and postgraduate students from the health, scientific and humanities schools at UJ. Survey sections included 26 items on: socio-demographic information, knowledge and sources of information about the disease, attitude towards the false notion that COVID-19 stemmed from a conspiracy and items to assess the anxiety level among students during the quarantine period. The total number of participants was 1540 students. The mean age of study participants was 22 years and females predominated the study population (n = 1145, 74.4%). The majority of participants perceived the disease as moderately dangerous (n = 1079, 70.1%). Males, Jordanians and participants with lower income were more inclined to feel that COVID-19 is very dangerous. A lower level of knowledge and a higher level of anxiety about COVID-19 were associated with the belief that the disease is part of a conspiracy. Females and participants with lower income were more likely to believe that the disease is related to conspiracy. Belief in conspiracy regarding the origin of COVID-19 was associated with misinformation about the availability of a vaccine and the therapeutic use of antibiotics for COVID-19 treatment. The Ministry of Health in Jordan was the most common source of information about COVID-19 reported by the participants (n = 1018). The false belief that COVID-19 was the result of a global conspiracy could be the consequence of a lower level of knowledge about the virus and could lead to a higher level of anxiety, which should be considered in the awareness tools of various media platforms about the current pandemic.", "doi": "10.3390/ijerph17144915", "pmid": "32650409", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "ijerph17144915"}, {"db": "pmc", "key": "PMC7399915"}], "notes": [], "created": "2020-12-08T14:17:45.329Z", "modified": "2022-11-10T07:40:15.463Z"}, {"entity": "publication", "iuid": "fb4d376b71a345b9aff49daecbc61a83", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb4d376b71a345b9aff49daecbc61a83.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb4d376b71a345b9aff49daecbc61a83"}}, "title": "Combination treatments with hydroxychloroquine and azithromycin are compatible with the therapeutic induction of anticancer immune responses.", "authors": [{"family": "Liu", "given": "Peng", "initials": "P"}, {"family": "Zhao", "given": "Liwei", "initials": "L"}, {"family": "Ferrere", "given": "Gladys", "initials": "G"}, {"family": "Alves-Costa-Silva", "given": "Carolina", "initials": "C"}, {"family": "Ly", "given": "Pierre", "initials": "P"}, {"family": "Wu", "given": "Qi", "initials": "Q"}, {"family": "Tian", "given": "Ai-Ling", "initials": "AL"}, {"family": "Derosa", "given": "Lisa", "initials": "L"}, {"family": "Zitvogel", "given": "Laurence", "initials": "L"}, {"family": "Kepp", "given": "Oliver", "initials": "O"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}], "type": "journal article", "published": "2020-07-08", "journal": {"title": "Oncoimmunology", "issn": "2162-4011", "volume": "9", "issue": "1", "pages": "1789284", "issn-l": null}, "abstract": "Amid controversial reports that COVID-19 can be treated with a combination of the antimalarial drug hydroxychloroquine (HCQ) and the antibiotic azithromycin (AZI), a clinical trial (ONCOCOVID, NCT04341207) was launched at Gustave Roussy Cancer Campus to investigate the utility of this combination therapy in cancer patients. In this preclinical study, we investigated whether the combination of HCQ+AZI would be compatible with the therapeutic induction of anticancer immune responses. For this, we used doses of HCQ and AZI that affect whole-body physiology (as indicated by a partial blockade in cardiac and hepatic autophagic flux for HCQ and a reduction in body weight for AZI), showing that their combined administration did not interfere with tumor growth control induced by the immunogenic cell death inducer oxaliplatin. Moreover, the HCQ+AZI combination did not affect the capacity of a curative regimen (cisplatin + crizotinib + PD-1 blockade) to eradicate established orthotopic lung cancers in mice. In conclusion, it appears that HCQ+AZI does not interfere with the therapeutic induction of therapeutic anticancer immune responses.", "doi": "10.1080/2162402X.2020.1789284", "pmid": "32923151", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "1789284"}, {"db": "pmc", "key": "PMC7458592"}], "notes": [], "created": "2020-12-03T15:36:32.115Z", "modified": "2021-02-26T08:45:03.362Z"}, {"entity": "publication", "iuid": "846ec4f0a2d84dc681ee8697ff6ea46c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/846ec4f0a2d84dc681ee8697ff6ea46c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/846ec4f0a2d84dc681ee8697ff6ea46c"}}, "title": "Wastewater-Based Epidemiology: Global Collaborative to Maximize Contributions in the Fight Against COVID-19.", "authors": [{"family": "Bivins", "given": "Aaron", "initials": "A"}, {"family": "North", "given": "Devin", "initials": "D"}, {"family": "Ahmad", "given": "Arslan", "initials": "A"}, {"family": "Ahmed", "given": "Warish", "initials": "W"}, {"family": "Alm", "given": "Eric", "initials": "E"}, {"family": "Been", "given": "Frederic", "initials": "F"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Bijlsma", "given": "Lubertus", "initials": "L"}, {"family": "Boehm", "given": "Alexandria B", "initials": "AB"}, {"family": "Brown", "given": "Joe", "initials": "J"}, {"family": "Buttiglieri", "given": "Gianluigi", "initials": "G"}, {"family": "Calabro", "given": "Vincenza", "initials": "V"}, {"family": "Carducci", "given": "Annalaura", "initials": "A"}, {"family": "Castiglioni", "given": "Sara", "initials": "S"}, {"family": "Cetecioglu Gurol", "given": "Zeynep", "initials": "Z"}, {"family": "Chakraborty", "given": "Sudip", "initials": "S"}, {"family": "Costa", "given": "Federico", "initials": "F"}, {"family": "Curcio", "given": "Stefano", "initials": "S"}, {"family": "de Los Reyes", "given": "Francis L", "initials": "FL"}, {"family": "Delgado Vela", "given": "Jeseth", "initials": "J"}, {"family": "Farkas", "given": "Kata", "initials": "K"}, {"family": "Fernandez-Casi", "given": "Xavier", "initials": "X"}, {"family": "Gerba", "given": "Charles", "initials": "C"}, {"family": "Gerrity", "given": "Daniel", "initials": "D"}, {"family": "Girones", "given": "Rosina", "initials": "R"}, {"family": "Gonzalez", "given": "Raul", "initials": "R"}, {"family": "Haramoto", "given": "Eiji", "initials": "E"}, {"family": "Harris", "given": "Angela", "initials": "A"}, {"family": "Holden", "given": "Patricia A", "initials": "PA"}, {"family": "Islam", "given": "Md Tahmidul", "initials": "MT"}, {"family": "Jones", "given": "Davey L", "initials": "DL"}, {"family": "Kasprzyk-Hordern", "given": "Barbara", "initials": "B"}, {"family": "Kitajima", "given": "Masaaki", "initials": "M"}, {"family": "Kotlarz", "given": "Nadine", "initials": "N"}, {"family": "Kumar", "given": "Manish", "initials": "M"}, {"family": "Kuroda", "given": "Keisuke", "initials": "K"}, {"family": "La Rosa", "given": "Giuseppina", "initials": "G"}, {"family": "Malpei", "given": "Francesca", "initials": "F"}, {"family": "Mautus", "given": "Mariana", "initials": "M"}, {"family": "McLellan", "given": "Sandra L", "initials": "SL"}, {"family": "Medema", "given": "Gertjan", "initials": "G"}, {"family": "Meschke", "given": "John Scott", "initials": "JS"}, {"family": "Mueller", "given": "Jochen", "initials": "J"}, {"family": "Newton", "given": "Ryan J", "initials": "RJ"}, {"family": "Nilsson", "given": "David", "initials": "D"}, {"family": "Noble", "given": "Rachel T", "initials": "RT"}, {"family": "van Nuijs", "given": "Alexander", "initials": "A"}, {"family": "Peccia", "given": "Jordan", "initials": "J"}, {"family": "Perkins", "given": "T Alex", "initials": "TA"}, {"family": "Pickering", "given": "Amy J", "initials": "AJ"}, {"family": "Rose", "given": "Joan", "initials": "J"}, {"family": "Sanchez", "given": "Gloria", "initials": "G"}, {"family": "Smith", "given": "Adam", "initials": "A"}, {"family": "Stadler", "given": "Lauren", "initials": "L"}, {"family": "Stauber", "given": "Christine", "initials": "C"}, {"family": "Thomas", "given": "Kevin", "initials": "K"}, {"family": "van der Voorn", "given": "Tom", "initials": "T"}, {"family": "Wigginton", "given": "Krista", "initials": "K"}, {"family": "Zhu", "given": "Kevin", "initials": "K"}, {"family": "Bibby", "given": "Kyle", "initials": "K"}], "type": "news", "published": "2020-07-07", "journal": {"title": "Environ Sci Technol", "issn": "1520-5851", "volume": "54", "issue": "13", "pages": "7754-7757", "issn-l": null}, "abstract": null, "doi": "10.1021/acs.est.0c02388", "pmid": "32530639", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7299382"}], "notes": [], "created": "2020-12-09T10:05:39.307Z", "modified": "2020-12-09T10:05:39.328Z"}, {"entity": "publication", "iuid": "6e381cbd252b437fa63080f76d62df4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e381cbd252b437fa63080f76d62df4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e381cbd252b437fa63080f76d62df4c"}}, "title": "Relationship Between Odor Intensity Estimates and COVID-19 Prevalence Prediction in a Swedish Population", "authors": [{"family": "Iravani", "given": "Behzad", "initials": "B", "orcid": "0000-0001-9905-1067", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5c799aeccef49a59531ad96984f466b.json"}}, {"family": "Arshamian", "given": "Artin", "initials": "A"}, {"family": "Ravia", "given": "Aharon", "initials": "A"}, {"family": "Mishor", "given": "Eva", "initials": "E"}, {"family": "Snitz", "given": "Kobi", "initials": "K"}, {"family": "Shushan", "given": "Sagit", "initials": "S"}, {"family": "Roth", "given": "Yehudah", "initials": "Y"}, {"family": "Perl", "given": "Ofer", "initials": "O"}, {"family": "Honigstein", "given": "Danielle", "initials": "D"}, {"family": "Weissgross", "given": "Reut", "initials": "R"}, {"family": "Karagach", "given": "Shiri", "initials": "S"}, {"family": "Ernst", "given": "Gernot", "initials": "G"}, {"family": "Okamoto", "given": "Masako", "initials": "M"}, {"family": "Mainen", "given": "Zachary", "initials": "Z"}, {"family": "Monteleone", "given": "Erminio", "initials": "E"}, {"family": "Dinnella", "given": "Caterina", "initials": "C"}, {"family": "Spinelli", "given": "Sara", "initials": "S"}, {"family": "Mari\u00f1o-S\u00e1nchez", "given": "Franklin", "initials": "F"}, {"family": "Ferdenzi", "given": "Camille", "initials": "C"}, {"family": "Smeets", "given": "Monique", "initials": "M"}, {"family": "Touhara", "given": "Kazushige", "initials": "K"}, {"family": "Bensafi", "given": "Moustafa", "initials": "M", "orcid": "0000-0002-2991-3036", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11b9f8b4dfbd4345ad03a0a694d5efcd.json"}}, {"family": "Hummel", "given": "Thomas", "initials": "T", "orcid": "0000-0001-9713-0183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/271198f0dc1f4b3fa9bef3d1225a24bf.json"}}, {"family": "Sobel", "given": "Noam", "initials": "N"}, {"family": "Lundstr\u00f6m", "given": "Johan N", "initials": "JN", "orcid": "0000-0002-3529-8981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a92f50aea024a1fbf0cfda979efef11.json"}}], "type": "journal-article", "published": "2020-07-07", "journal": {"title": "Chem Senses", "issn": "0379-864X", "volume": "45", "issue": "6", "pages": "449-456", "issn-l": null}, "abstract": "In response to the COVID-19 pandemic, countries have implemented various strategies to reduce and slow the spread of the disease in the general population. For countries that have implemented restrictions on its population in a step-wise manner, monitoring of COVID-19 prevalence is of importance to guide decision on when to impose new, or when to abolish old, restrictions. We are here determining whether measures of odor intensity in a large sample can serve as one such measure. Online measures of how intense common household odors are perceived and symptoms of COVID-19 were collected from 2440 Swedes. Average odor intensity ratings were then compared to predicted COVID-19 population prevalence over time in the Swedish population and were found to closely track each other (r=-0.83). Moreover, we found that there was a large difference in rated intensity between individuals with and without COVID-19 symptoms and number of symptoms was related to odor intensity ratings. Finally, we found that individuals progressing from reporting no symptoms to subsequently reporting COVID-19 symptoms demonstrated a large drop in olfactory performance. These data suggest that measures of odor intensity, if obtained in a large and representative sample, can be used as an indicator of COVID-19 disease in the general population. Importantly, this simple measure could easily be implemented in countries without widespread access to COVID-19 testing or implemented as a fast early response before wide-spread testing can be facilitated.", "doi": "10.1093/chemse/bjaa034", "pmid": "32441744", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "5842049"}, {"db": "pmc", "key": "PMC7314115"}], "notes": [], "created": "2020-11-25T09:11:13.432Z", "modified": "2021-12-06T13:17:58.519Z"}, {"entity": "publication", "iuid": "46bea90f079749b5acc9ceed9a2570f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46bea90f079749b5acc9ceed9a2570f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46bea90f079749b5acc9ceed9a2570f9"}}, "title": "Has Venoarterial ECMO Been Underutilized in COVID-19 Patients?", "authors": [{"family": "De Piero", "given": "Maria Elena", "initials": "ME"}, {"family": "Lo Coco", "given": "Valeria", "initials": "V"}, {"family": "Taccone", "given": "Fabio Silvio", "initials": "FS"}, {"family": "Belliato", "given": "Mirko", "initials": "M"}, {"family": "Broman", "given": "Lars M", "initials": "LM"}, {"family": "Malfertheiner", "given": "Maximilian V", "initials": "MV"}, {"family": "Lorusso", "given": "Roberto", "initials": "R"}], "type": "editorial", "published": "2020-07-07", "journal": {"title": "Innovations (Phila)", "issn": "1559-0879", "volume": "15", "issue": "4", "pages": "317-321", "issn-l": null}, "abstract": null, "doi": "10.1177/1556984520939076", "pmid": "32634058", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-08T14:36:09.388Z", "modified": "2020-12-08T14:36:09.411Z"}, {"entity": "publication", "iuid": "0ad3e7bd357b483e955e3a096d969e77", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ad3e7bd357b483e955e3a096d969e77.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ad3e7bd357b483e955e3a096d969e77"}}, "title": "European consensus recommendations for neonatal and paediatric retrievals of positive or suspected COVID-19 patients.", "authors": [{"family": "Terheggen", "given": "Ulrich", "initials": "U"}, {"family": "Heiring", "given": "Christian", "initials": "C"}, {"family": "Kjellberg", "given": "Mattias", "initials": "M"}, {"family": "Hegardt", "given": "Fredrik", "initials": "F"}, {"family": "Kneyber", "given": "Martin", "initials": "M"}, {"family": "Gente", "given": "Maurizio", "initials": "M"}, {"family": "Roehr", "given": "Charles C", "initials": "CC"}, {"family": "Jourdain", "given": "Gilles", "initials": "G"}, {"family": "Tissieres", "given": "Pierre", "initials": "P"}, {"family": "Ramnarayan", "given": "Padmanabhan", "initials": "P"}, {"family": "Breindahl", "given": "Morten", "initials": "M"}, {"family": "van den Berg", "given": "Johannes", "initials": "J"}], "type": "journal article", "published": "2020-07-07", "journal": {"title": "Pediatr Res", "issn": "1530-0447", "volume": null, "issue": null, "pages": null, "issn-l": "0031-3998"}, "abstract": "The 2020 novel coronavirus (SARS-Cov-2) pandemic necessitates tailored recommendations addressing specific procedures for neonatal and paediatric transport of suspected or positive COVID-19 patients. The aim of this consensus statement is to define guidelines for safe clinical care for children needing inter-facility transport while making sure that the clinical teams involved are sufficiently protected from SARS-CoV-2.\r\n\r\nA taskforce, composed of members of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC) Transport section and the European Society for Paediatric Research (ESPR), reviewed the published literature and used a rapid, two-step modified Delphi process to formulate recommendations regarding safety and clinical management during transport of COVID-19 patients.\r\n\r\nThe joint taskforce consisted of a panel of 12 experts who reached an agreement on a set of 17 recommendations specifying pertinent aspects on neonatal and paediatric COVID-19 patient transport. These included: case definition, personal protective equipment, airway management, equipment and strategies for invasive and non-invasive ventilation, special considerations for incubator and open stretcher transports, parents on transport and decontamination of transport vehicles.\r\n\r\nOur consensus recommendations aim to define current best-practice and should help guide transport teams dealing with infants and children with COVID-19 to work safely and effectively.\r\n\r\nWe present European consensus recommendations on pertinent measures for transporting infants and children in times of the coronavirus (SARS-Cov-2 /COVID-19) pandemic.A panel of experts reviewed the evidence around transporting infants and children with proven or suspected COVID-19. Specific guidance on aspects of personal protective equipment, airway management and considerations for incubator and open stretcher transports is presented.Based on scant evidence, best-practice recommendations for neonatal and paediatric transport teams are presented, aiming for the protection of teams and patients. We highlight gaps in knowledge and areas of future research.", "doi": "10.1038/s41390-020-1050-z", "pmid": "32634819", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41390-020-1050-z"}], "notes": [], "created": "2020-11-19T14:31:03.050Z", "modified": "2020-11-30T08:51:26.698Z"}, {"entity": "publication", "iuid": "9f4418e203d646a3aea9f4da8d915c56", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f4418e203d646a3aea9f4da8d915c56.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f4418e203d646a3aea9f4da8d915c56"}}, "title": "Complete protection from covid-19 is possible for health workers.", "authors": [{"family": "Karlsson", "given": "Ulf", "initials": "U"}, {"family": "Fraenkel", "given": "Carl-Johan", "initials": "CJ"}], "type": "editorial", "published": "2020-07-07", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "370", "issue": null, "pages": "m2641", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m2641", "pmid": "32636186", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-08T14:30:49.116Z", "modified": "2020-12-08T14:30:49.127Z"}, {"entity": "publication", "iuid": "f9d8dc3406334b78bbea45064cff29ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f9d8dc3406334b78bbea45064cff29ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f9d8dc3406334b78bbea45064cff29ee"}}, "title": "[The virtual ward - the students' clinical education during the current pandemic].", "authors": [{"family": "Robertson", "given": "Josefina", "initials": "J"}, {"family": "Ahlgren", "given": "Erika", "initials": "E"}, {"family": "Rydberg", "given": "Frida", "initials": "F"}, {"family": "Snygg-Martin", "given": "Ulrika", "initials": "U"}, {"family": "Westin", "given": "Johan", "initials": "J"}, {"family": "Studahl", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2020-07-06", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "volume": "117", "issue": null, "issn-l": "0023-7205"}, "abstract": "On March 17, 2020, the Swedish Government recommended all higher education institutions to move to online and distance learning during the COVID-19 pandemic. The integrated course in Infection, Microbiology, and Immunity at the Programme in Medicine at University of Gothenburg had to be completely transformed. Creative solutions have now replaced the clinical training that normally takes place during the students' clinical education at the hospital. We developed a digital concept entitled \"the virtual ward\", in which we interact with the students in real time. Here, the students are able to follow their patients on a daily basis during teacher-guided sessions.", "doi": null, "pmid": "32633809", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "20077"}], "notes": [], "created": "2020-12-08T14:39:33.360Z", "modified": "2020-12-08T14:39:33.372Z"}, {"entity": "publication", "iuid": "8b1c4e0ddc2441c08331bc2a0429303d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b1c4e0ddc2441c08331bc2a0429303d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b1c4e0ddc2441c08331bc2a0429303d"}}, "title": "Why policy action should focus on the vulnerable commercial sex workers in Uganda during COVID-19 fight.", "authors": [{"family": "Kawala", "given": "Brenda Allen", "initials": "BA"}, {"family": "Kirui", "given": "Brian Kibiwott", "initials": "BK"}, {"family": "Cumber", "given": "Samuel Nambile", "initials": "SN"}], "type": "letter", "published": "2020-07-06", "journal": {"title": "Pan Afr Med J", "issn": "1937-8688", "volume": "35", "issue": "Suppl 2", "pages": "102", "issn-l": null}, "abstract": null, "doi": "10.11604/pamj.supp.2020.35.2.24664", "pmid": "33282057", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "PAMJ-SUPP-35-2-102"}, {"db": "pmc", "key": "PMC7687465"}], "notes": [], "created": "2020-12-10T09:18:47.080Z", "modified": "2020-12-10T09:18:47.091Z"}, {"entity": "publication", "iuid": "7207513ff7874785b676fa1a4be24ddb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7207513ff7874785b676fa1a4be24ddb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7207513ff7874785b676fa1a4be24ddb"}}, "title": "Anti-coagulation for COVID-19 treatment: both anti-thrombotic and anti-inflammatory?", "authors": [{"family": "Paar", "given": "Vera", "initials": "V"}, {"family": "Wernly", "given": "Bernhard", "initials": "B"}, {"family": "Zhou", "given": "Zhichao", "initials": "Z"}, {"family": "Motloch", "given": "Lukas J", "initials": "LJ"}, {"family": "Hoppe", "given": "Uta C", "initials": "UC"}, {"family": "Egle", "given": "Alexander", "initials": "A"}, {"family": "Lichtenauer", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2020-07-06", "journal": {"title": "J Thromb Thrombolysis", "issn": "1573-742X", "volume": null, "issue": null, "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has been linked to a higher risk of mortality compared to influenza, which is mainly due to severe secondary diseases, such as acute respiratory distress syndrome (ARDS). In turn, ARDS is characterized by an acute inflammation and an excessive activity of the coagulation cascade, rising the vulnerability for venous thromboembolic events. In order to investigate the relation of inflammation and the influence of coagulation factors on their release, human peripheral mononuclear blood cells (PBMCs) were treated with autologous serum, heparinized plasma and different doses of fibrin. Thereafter, the concentration of pro-inflammatory cytokines and chemokines in the secretome of PBMCs was measured by enzyme-linked immunosorbent assay. Our analyses revealed autologous serum to significantly increase the secretion of cytokines and chemokines after 24 h of incubation time. Furthermore, the addition of fibrin markedly increased the secretion of cytokines and chemokines by PBMCs in a dose-dependent manner. Consequently, in accordance with previous studies, our study outlines that anti-coagulation may constitute a promising tool for the treatment of SARS-CoV-2, reducing both, the cytokine storm, as well as the risk for thrombotic complications.", "doi": "10.1007/s11239-020-02212-6", "pmid": "32632558", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11239-020-02212-6"}, {"db": "pmc", "key": "PMC7338133"}], "notes": [], "created": "2020-12-08T14:40:18.189Z", "modified": "2021-02-26T08:45:03.055Z"}, {"entity": "publication", "iuid": "ab46cb3b389f498e9f66c700d13ce759", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ab46cb3b389f498e9f66c700d13ce759.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ab46cb3b389f498e9f66c700d13ce759"}}, "title": "A Silent Infection Pandemic of COVID-19: Epidemiological Investigation and Hypothetical Models.", "authors": [{"family": "Geng", "given": "Jianping", "initials": "J"}, {"family": "Yu", "given": "Jun", "initials": "J", "orcid": "0000-0003-2006-758X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30dd1b66e1284ab1aa3566ab21556595.json"}}, {"family": "Lu", "given": "Tao", "initials": "T"}, {"family": "Wang", "given": "Yinhe", "initials": "Y"}, {"family": "Cao", "given": "Yang", "initials": "Y", "orcid": "0000-0002-3552-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7594ca0fdf2d4f238ca04a788a405cdb.json"}}], "type": "journal article", "published": "2020-07-05", "journal": {"title": "Can J Infect Dis Med Microbiol", "issn": "1712-9532", "volume": "2020", "issue": null, "pages": "5120253", "issn-l": null}, "abstract": "To explore the epidemic mode of COVID-19, we made an epidemiological investigation, set up hypothetical models, and compared them with hepatitis A virus (HAV) age-specific epidemic characteristic. In the epidemiological investigation, we reported the first familial COVID-19 silent infection in the world. A 19-year-old healthy female COVID-19 virus carrier without any symptoms caused two mild and one severe pneumonia. In hypothetical models, the silent infection rate ranges from 60% to 80% based on 3 sources: China mainland, evacuation of 4 nationals, and the ship \"Diamond Princess,\" respectively. In comparison with HAV, COVID-19 shows the same infection mode in children (aged 0-9 years), but significant difference in young adults (aged 10-44 years) and the elderly (aged 45 years or older). Therefore, we prejudged that COVID-19 is a silent infection pandemic mainly in young adults but threatens the elderly.", "doi": "10.1155/2020/5120253", "pmid": "32670439", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7341389"}], "notes": [], "created": "2020-12-07T16:37:05.988Z", "modified": "2023-06-19T14:36:40.335Z"}, {"entity": "publication", "iuid": "9c6f1f68c72547ee948469c8d27d2ff3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9c6f1f68c72547ee948469c8d27d2ff3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9c6f1f68c72547ee948469c8d27d2ff3"}}, "title": "Rapid Detection of COVID-19 Coronavirus Using a Reverse Transcriptional Loop-Mediated Isothermal Amplification (RT-LAMP) Diagnostic Platform", "authors": [{"family": "Yu", "given": "Lin", "initials": "L"}, {"family": "Wu", "given": "Shanshan", "initials": "S"}, {"family": "Hao", "given": "Xiaowen", "initials": "X"}, {"family": "Dong", "given": "Xue", "initials": "X"}, {"family": "Mao", "given": "Lingling", "initials": "L"}, {"family": "Pelechano", "given": "Vicent", "initials": "V"}, {"family": "Chen", "given": "Wei Hua", "initials": "WH"}, {"family": "Yin", "given": "Xiushan", "initials": "X"}], "type": "journal-article", "published": "2020-07-01", "journal": {"title": "Clin Chem", "issn": "0009-9147", "issn-l": null, "volume": "66", "issue": "7", "pages": "975-977"}, "abstract": null, "doi": "10.1093/clinchem/hvaa102", "pmid": "32315390", "labels": {"Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Research Area: Diagnostics for virus": null, "Funder: VR": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "5823294"}, {"db": "pmc", "key": "PMC7188121"}], "notes": [], "created": "2020-11-04T07:17:58.514Z", "modified": "2022-02-14T06:39:01.697Z"}, {"entity": "publication", "iuid": "7c12e4c6f6564264835fcdd9ee827c45", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7c12e4c6f6564264835fcdd9ee827c45.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7c12e4c6f6564264835fcdd9ee827c45"}}, "title": "Managing COVID-19 spread with voluntary public-health measures: Sweden as a case study for pandemic control.", "authors": [{"family": "Kamerlin", "given": "Shina C L", "initials": "SCL"}, {"family": "Kasson", "given": "Peter M", "initials": "PM"}], "type": "journal article", "published": "2020-07-01", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "issn-l": "1058-4838", "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic has spread globally, causing extensive illness and mortality. In advance of effective antiviral therapies, countries have applied different public-health strategies to control spread and manage healthcare need. Sweden has taken a unique approach of not implementing strict closures, instead urging personal responsibility. We analyze the results of this and other potential strategies for pandemic control in Sweden.\r\n\r\nWe implemented individual-based modeling of COVID-19 spread in Sweden using population, employment, and household data. Epidemiological parameters for COVID-19 were validated on a limited date range; where substantial uncertainties remained, multiple parameters were tested. The effects of different public-health strategies were tested over a 160-day period, analyzed for their effects on ICU demand and death rate, and compared to Swedish data for April 2020.\r\n\r\nSwedish mortality rates fall intermediate between European countries that quickly imposed stringent public-health controls and countries that acted later. Models most closely reproducing reported mortality data suggest large portions of the population voluntarily self-isolate. Swedish ICU utilization rates remained lower than predicted, but a large fraction of deaths occurred in non-ICU patients. This suggests that patient prognosis was considered in ICU admission, reducing healthcare load at a cost of decreased survival in patients not admitted.\r\n\r\nThe Swedish COVID-19 strategy has thus far yielded a striking result: mild mandates overlaid with voluntary measures can achieve results highly similar to late-onset stringent mandates. However, this policy causes more healthcare demand and mortality than early stringent control and depends on continued public will.", "doi": "10.1093/cid/ciaa864", "pmid": "32609825", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "5866094"}, {"db": "pmc", "key": "PMC7337695"}], "notes": [], "created": "2020-12-08T15:22:07.519Z", "modified": "2022-11-10T07:46:04.133Z"}, {"entity": "publication", "iuid": "541e95e5a6334de69e1c372342eaaf59", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/541e95e5a6334de69e1c372342eaaf59.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/541e95e5a6334de69e1c372342eaaf59"}}, "title": "Utilitarianism and the pandemic.", "authors": [{"family": "Savulescu", "given": "Julian", "initials": "J"}, {"family": "Persson", "given": "Ingmar", "initials": "I"}, {"family": "Wilkinson", "given": "Dominic", "initials": "D"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Bioethics", "issn": "1467-8519", "volume": "34", "issue": "6", "pages": "620-632", "issn-l": null}, "abstract": "There are no egalitarians in a pandemic. The scale of the challenge for health systems and public policy means that there is an ineluctable need to prioritize the needs of the many. It is impossible to treat all citizens equally, and a failure to carefully consider the consequences of actions could lead to massive preventable loss of life. In a pandemic there is a strong ethical need to consider how to do most good overall. Utilitarianism is an influential moral theory that states that the right action is the action that is expected to produce the greatest good. It offers clear operationalizable principles. In this paper we provide a summary of how utilitarianism could inform two challenging questions that have been important in the early phase of the pandemic: (a) Triage: which patients should receive access to a ventilator if there is overwhelming demand outstripping supply? (b) Lockdown: how should countries decide when to implement stringent social restrictions, balancing preventing deaths from COVID-19 with causing deaths and reductions in well-being from other causes? Our aim is not to argue that utilitarianism is the only relevant ethical theory, or in favour of a purely utilitarian approach. However, clearly considering which options will do the most good overall will help societies identify and consider the necessary cost of other values. Societies may choose either to embrace or not to embrace the utilitarian course, but with a clear understanding of the values involved and the price they are willing to pay.", "doi": "10.1111/bioe.12771", "pmid": "32433782", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7276855"}], "notes": [], "created": "2020-12-09T11:36:17.611Z", "modified": "2020-12-09T11:36:17.636Z"}, {"entity": "publication", "iuid": "a43e85c7b8bd42f98fbfd6c4a67d3a83", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a43e85c7b8bd42f98fbfd6c4a67d3a83.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a43e85c7b8bd42f98fbfd6c4a67d3a83"}}, "title": "Uncovering the Devaluation of Nursing Home Staff During COVID-19: Are We Fuelling the Next Health Care Crisis?", "authors": [{"family": "McGilton", "given": "Katherine S", "initials": "KS"}, {"family": "Escrig-Pinol", "given": "Astrid", "initials": "A"}, {"family": "Gordon", "given": "Adam", "initials": "A"}, {"family": "Chu", "given": "Charlene H", "initials": "CH"}, {"family": "Z\u00fa\u00f1iga", "given": "Franziska", "initials": "F"}, {"family": "Sanchez", "given": "Montserrat Gea", "initials": "MG"}, {"family": "Boscart", "given": "Veronique", "initials": "V"}, {"family": "Meyer", "given": "Julienne", "initials": "J"}, {"family": "Corazzini", "given": "Kirsten N", "initials": "KN"}, {"family": "Jacinto", "given": "Alessandro Ferrari", "initials": "AF"}, {"family": "Spilsbury", "given": "Karen", "initials": "K"}, {"family": "Backman", "given": "Annica", "initials": "A"}, {"family": "Scales", "given": "Kezia", "initials": "K"}, {"family": "Fagertun", "given": "Anette", "initials": "A"}, {"family": "Wu", "given": "Bei", "initials": "B"}, {"family": "Edvardsson", "given": "David", "initials": "D"}, {"family": "Lepore", "given": "Michael J", "initials": "MJ"}, {"family": "Leung", "given": "Angela Y M", "initials": "AYM"}, {"family": "Siegel", "given": "Elena O", "initials": "EO"}, {"family": "Noguchi-Watanabe", "given": "Maiko", "initials": "M"}, {"family": "Wang", "given": "Jing", "initials": "J"}, {"family": "Bowers", "given": "Barbara", "initials": "B"}], "type": "editorial", "published": "2020-07-00", "journal": {"title": "J Am Med Dir Assoc", "issn": "1538-9375", "volume": "21", "issue": "7", "pages": "962-965", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jamda.2020.06.010", "pmid": "32674829", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1525-8610(20)30492-8"}, {"db": "pmc", "key": "PMC7287421"}], "notes": [], "created": "2020-12-07T16:36:02.866Z", "modified": "2020-12-07T16:36:02.876Z"}, {"entity": "publication", "iuid": "280d2226abe54b8989ec40218181f134", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/280d2226abe54b8989ec40218181f134.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/280d2226abe54b8989ec40218181f134"}}, "title": "Unconventional Answers to Unprecedented Challenges: The Swedish Experience During the COVID-19 Outbreak.", "authors": [{"family": "Valeriani", "given": "Giuseppe", "initials": "G"}, {"family": "Vukovic", "given": "Iris Sarajlic", "initials": "IS"}, {"family": "Mollica", "given": "Richard", "initials": "R"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "J Prev Med Public Health", "issn": "2233-4521", "volume": "53", "issue": "4", "pages": "233-235", "issn-l": null}, "abstract": "Since its early stages, the coronavirus disease 2019 (COVID-19) pandemic has posed immense challenges in meeting the public health and healthcare and social care needs of migrants. In line with other reports from United Kingdom and United States, data from Sweden's health authority show that migrants have been disproportionately affected by COVID-19. Following the World Health Organization's statements, as well as the European Public Health Association's call for action, several centres in Sweden's most populated areas have activated tools to implement national plans for community outreach through initiatives targeting migrants and ethnic minority groups. Unconventional means should be promoted to mitigate the impact of COVID-19 on migrants and the health of the public at large.", "doi": "10.3961/jpmph.20.235", "pmid": "32752592", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jpmph.20.235"}, {"db": "pmc", "key": "PMC7411250"}], "notes": [], "created": "2020-11-30T08:44:12.012Z", "modified": "2020-11-30T08:44:12.036Z"}, {"entity": "publication", "iuid": "12b4dcc8dc3f4da3aa0981fb96c7e217", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/12b4dcc8dc3f4da3aa0981fb96c7e217.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/12b4dcc8dc3f4da3aa0981fb96c7e217"}}, "title": "The protein expression profile of ACE2 in human tissues.", "authors": [{"family": "Hikmet", "given": "Feria", "initials": "F", "orcid": "0000-0002-3750-9308", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/511acd3a0f344f119d0986f304edda13.json"}}, {"family": "M\u00e9ar", "given": "Loren", "initials": "L"}, {"family": "Edvinsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Micke", "given": "Patrick", "initials": "P"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cfef77b64f644d498532e5e2572a8c5c.json"}}, {"family": "Lindskog", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-5611-1015", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4ead3d38a364b66ac069b9c8bf63897.json"}}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Mol Syst Biol", "issn": "1744-4292", "issn-l": "1744-4292", "volume": "16", "issue": "7", "pages": "e9610"}, "abstract": "The novel SARS-coronavirus 2 (SARS-CoV-2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS-CoV-2 infection, the cell type-specific expression of the host cell surface receptor is necessary. The key protein suggested to be involved in host cell entry is angiotensin I converting enzyme 2 (ACE2). Here, we report the expression pattern of ACE2 across > 150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis. The results were compared with several datasets both on the mRNA and protein level. ACE2 expression was mainly observed in enterocytes, renal tubules, gallbladder, cardiomyocytes, male reproductive cells, placental trophoblasts, ductal cells, eye, and vasculature. In the respiratory system, the expression was limited, with no or only low expression in a subset of cells in a few individuals, observed by one antibody only. Our data constitute an important resource for further studies on SARS-CoV-2 host cell entry, in order to understand the biology of the disease and to aid in the development of effective treatments to the viral infection.", "doi": "10.15252/msb.20209610", "pmid": "32715618", "labels": {"Category: Biochemistry": null, "Category: Proteins": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7383091"}], "notes": [], "created": "2021-06-14T14:56:19.700Z", "modified": "2021-11-26T09:46:31.768Z"}, {"entity": "publication", "iuid": "49eeff9c7fc148e1b2f90ac1722df1c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49eeff9c7fc148e1b2f90ac1722df1c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49eeff9c7fc148e1b2f90ac1722df1c5"}}, "title": "The potential long-term impact of the COVID-19 outbreak on patients with non-communicable diseases in Europe: consequences for healthy ageing.", "authors": [{"family": "Palmer", "given": "Katie", "initials": "K"}, {"family": "Monaco", "given": "Alessandro", "initials": "A"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Onder", "given": "Graziano", "initials": "G"}, {"family": "Maggi", "given": "Stefania", "initials": "S"}, {"family": "Michel", "given": "Jean-Pierre", "initials": "JP"}, {"family": "Prieto", "given": "Rita", "initials": "R"}, {"family": "Sykara", "given": "Georgia", "initials": "G"}, {"family": "Donde", "given": "Shaantanu", "initials": "S"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Aging Clin Exp Res", "issn": "1720-8319", "volume": "32", "issue": "7", "pages": "1189-1194", "issn-l": "1594-0667"}, "abstract": "The early stages of the COVID-19 pandemic have focused on containing SARS-CoV-2 infection and identifying treatment strategies. While controlling this communicable disease is of utmost importance, the long-term effect on individuals with non-communicable diseases (NCD) is significant. Although certain NCDs appear to increase the severity of COVID-19 and mortality risk, SARS-CoV-2 infection in survivors with NCDs may also affect the progression of their pre-existing clinical conditions. Infection containment measures will have substantial short- and long-term consequences; social distancing and quarantine restrictions will reduce physical activity and increase other unhealthy lifestyles, thus increasing NCD risk factors and worsening clinical symptoms. Vitamin D levels might decrease and there might be a rise in mental health disorders. Many countries have made changes to routine management of NCD patients, e.g., cancelling non-urgent outpatient visits, which will have important implications for NCD management, diagnosis of new-onset NCDs, medication adherence, and NCD progression. We may have opportunities to learn from this unprecedented crisis on how to leverage healthcare technologies and improve procedures to optimize healthcare service provision. This article discusses how the COVID-19 outbreak and related infection control measures could hit the most frail individuals, worsening the condition of NCD patients, while further jeopardizing the sustainability of the healthcare systems. We suggest ways to define an integrated strategy that could involve both public institutional entities and the private sector to safeguard frail individuals and mitigate the impact of the outbreak.", "doi": "10.1007/s40520-020-01601-4", "pmid": "32458356", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40520-020-01601-4"}, {"db": "pmc", "key": "PMC7248450"}], "notes": [], "created": "2020-11-25T09:17:28.876Z", "modified": "2020-11-30T09:02:33.085Z"}, {"entity": "publication", "iuid": "c81e59dc42e44e30a7c6de749c714271", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c81e59dc42e44e30a7c6de749c714271.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c81e59dc42e44e30a7c6de749c714271"}}, "title": "The Vascular Surgery COVID-19 Collaborative (VASCC).", "authors": [{"family": "Mouawad", "given": "Nicolas J", "initials": "NJ"}, {"family": "Cuff", "given": "Robert F", "initials": "RF"}, {"family": "Hultgren", "given": "Rebecka", "initials": "R"}, {"family": "Chuen", "given": "Jason", "initials": "J"}, {"family": "Galeazzi", "given": "Edoardo", "initials": "E"}, {"family": "Wohlauer", "given": "Max", "initials": "M"}], "type": "letter", "published": "2020-07-00", "journal": {"title": "J Vasc Surg", "issn": "1097-6809", "volume": "72", "issue": "1", "pages": "379-380", "issn-l": "0741-5214"}, "abstract": "Letter to the editor", "doi": "10.1016/j.jvs.2020.04.463", "pmid": "32334050", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0741-5214(20)31054-5"}, {"db": "pmc", "key": "PMC7175883"}], "notes": [], "created": "2020-11-23T11:51:10.065Z", "modified": "2020-12-09T14:58:38.311Z"}, {"entity": "publication", "iuid": "c5ba8db7add244e7afb0dc120c5eef53", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5ba8db7add244e7afb0dc120c5eef53.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5ba8db7add244e7afb0dc120c5eef53"}}, "title": "The Use of eHealth for the Care of Patients With Diabetes in Connection to the COVID-19 Pandemic.", "authors": [{"family": "Jendle", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "J Diabetes Sci Technol", "issn": "1932-2968", "volume": "14", "issue": "4", "pages": "739-740", "issn-l": null}, "abstract": null, "doi": "10.1177/1932296820922623", "pmid": "32375494", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7673160"}], "notes": [], "created": "2020-12-10T07:34:11.628Z", "modified": "2020-12-10T07:34:20.300Z"}, {"entity": "publication", "iuid": "0a8b001724604a96921c186e67b47605", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a8b001724604a96921c186e67b47605.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a8b001724604a96921c186e67b47605"}}, "title": "The COronavirus Pandemic Epidemiology (COPE) Consortium: A Call to Action.", "authors": [{"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Nguyen", "given": "Long H", "initials": "LH"}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Guo", "given": "Chuan-Guo", "initials": "CG"}, {"family": "Lo", "given": "Chun-Han", "initials": "CH"}, {"family": "Mehta", "given": "Raaj S", "initials": "RS"}, {"family": "Kwon", "given": "Sohee", "initials": "S"}, {"family": "Sikavi", "given": "Daniel R", "initials": "DR"}, {"family": "Magicheva-Gupta", "given": "Marina V", "initials": "MV"}, {"family": "Fatehi", "given": "Zahra S", "initials": "ZS"}, {"family": "Flynn", "given": "Jacqueline J", "initials": "JJ"}, {"family": "Leonardo", "given": "Brianna M", "initials": "BM"}, {"family": "Albert", "given": "Christine M", "initials": "CM"}, {"family": "Andreotti", "given": "Gabriella", "initials": "G"}, {"family": "Beane-Freeman", "given": "Laura E", "initials": "LE"}, {"family": "Balasubramanian", "given": "Bijal A", "initials": "BA"}, {"family": "Brownstein", "given": "John S", "initials": "JS"}, {"family": "Bruinsma", "given": "Fiona", "initials": "F"}, {"family": "Cowan", "given": "Annie N", "initials": "AN"}, {"family": "Deka", "given": "Anusila", "initials": "A"}, {"family": "Ernst", "given": "Michael E", "initials": "ME"}, {"family": "Figueiredo", "given": "Jane C", "initials": "JC"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Gardner", "given": "Christopher D", "initials": "CD"}, {"family": "Ghobrial", "given": "Irene M", "initials": "IM"}, {"family": "Haiman", "given": "Christopher A", "initials": "CA"}, {"family": "Hall", "given": "Janet E", "initials": "JE"}, {"family": "Deming-Halverson", "given": "Sandra L", "initials": "SL"}, {"family": "Kirpach", "given": "Brenda", "initials": "B"}, {"family": "Lacey", "given": "James V", "initials": "JV"}, {"family": "Marchand", "given": "Lo\u00efc Le", "initials": "LL"}, {"family": "Marinac", "given": "Catherine R", "initials": "CR"}, {"family": "Martinez", "given": "Maria Elena", "initials": "ME"}, {"family": "Milne", "given": "Roger L", "initials": "RL"}, {"family": "Murray", "given": "Anne M", "initials": "AM"}, {"family": "Nash", "given": "Denis", "initials": "D"}, {"family": "Palmer", "given": "Julie R", "initials": "JR"}, {"family": "Patel", "given": "Alpa V", "initials": "AV"}, {"family": "Rosenberg", "given": "Lynn", "initials": "L"}, {"family": "Sandler", "given": "Dale P", "initials": "DP"}, {"family": "Sharma", "given": "Shreela V", "initials": "SV"}, {"family": "Schurman", "given": "Shepherd H", "initials": "SH"}, {"family": "Wilkens", "given": "Lynne R", "initials": "LR"}, {"family": "Chavarro", "given": "Jorge E", "initials": "JE"}, {"family": "Eliassen", "given": "A Heather", "initials": "AH"}, {"family": "Hart", "given": "Jaime E", "initials": "JE"}, {"family": "Kang", "given": "Jae Hee", "initials": "JH"}, {"family": "Koenen", "given": "Karestan C", "initials": "KC"}, {"family": "Kubzansky", "given": "Laura D", "initials": "LD"}, {"family": "Mucci", "given": "Lorelei A", "initials": "LA"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Rich-Edwards", "given": "Janet W", "initials": "JW"}, {"family": "Song", "given": "Mingyang", "initials": "M"}, {"family": "Stampfer", "given": "Meir J", "initials": "MJ"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Willett", "given": "Walter C", "initials": "WC"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Spector", "given": "Tim", "initials": "T"}, {"family": "COPE Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Cancer Epidemiol Biomarkers Prev", "issn": "1538-7755", "volume": "29", "issue": "7", "pages": "1283-1289", "issn-l": null}, "abstract": "The rapid pace of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; COVID-19) pandemic presents challenges to the real-time collection of population-scale data to inform near-term public health needs as well as future investigations. We established the COronavirus Pandemic Epidemiology (COPE) consortium to address this unprecedented crisis on behalf of the epidemiology research community. As a central component of this initiative, we have developed a COVID Symptom Study (previously known as the COVID Symptom Tracker) mobile application as a common data collection tool for epidemiologic cohort studies with active study participants. This mobile application collects information on risk factors, daily symptoms, and outcomes through a user-friendly interface that minimizes participant burden. Combined with our efforts within the general population, data collected from nearly 3 million participants in the United States and United Kingdom are being used to address critical needs in the emergency response, including identifying potential hot spots of disease and clinically actionable risk factors. The linkage of symptom data collected in the app with information and biospecimens already collected in epidemiology cohorts will position us to address key questions related to diet, lifestyle, environmental, and socioeconomic factors on susceptibility to COVID-19, clinical outcomes related to infection, and long-term physical, mental health, and financial sequalae. We call upon additional epidemiology cohorts to join this collective effort to strengthen our impact on the current health crisis and generate a new model for a collaborative and nimble research infrastructure that will lead to more rapid translation of our work for the betterment of public health.", "doi": "10.1158/1055-9965.EPI-20-0606", "pmid": "32371551", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "1055-9965.EPI-20-0606"}, {"db": "pmc", "key": "PMC7357669"}, {"db": "mid", "key": "NIHMS1605601"}], "notes": [], "created": "2020-11-30T09:10:08.022Z", "modified": "2020-11-30T09:10:08.046Z"}, {"entity": "publication", "iuid": "e0e15dfc412146968881757d0e0c0e1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e0e15dfc412146968881757d0e0c0e1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e0e15dfc412146968881757d0e0c0e1d"}}, "title": "Structure-based drug designing and immunoinformatics approach for SARS-CoV-2.", "authors": [{"family": "Panda", "given": "Pritam Kumar", "initials": "PK"}, {"family": "Arul", "given": "Murugan Natarajan", "initials": "MN"}, {"family": "Patel", "given": "Paritosh", "initials": "P"}, {"family": "Verma", "given": "Suresh K", "initials": "SK"}, {"family": "Luo", "given": "Wei", "initials": "W"}, {"family": "Rubahn", "given": "Horst-G\u00fcnter", "initials": "H"}, {"family": "Mishra", "given": "Yogendra Kumar", "initials": "YK"}, {"family": "Suar", "given": "Mrutyunjay", "initials": "M"}, {"family": "Ahuja", "given": "Rajeev", "initials": "R"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Sci Adv", "issn": "2375-2548", "issn-l": "2375-2548", "volume": "6", "issue": "28", "pages": "eabb8097"}, "abstract": "The prevalence of respiratory illness caused by the novel SARS-CoV-2 virus associated with multiple organ failures is spreading rapidly because of its contagious human-to-human transmission and inadequate globalhealth care systems. Pharmaceutical repurposing, an effective drug development technique using existing drugs, could shorten development time and reduce costs compared to those of de novo drug discovery. We carried out virtual screening of antiviral compounds targeting the spike glycoprotein (S), main protease (M pro), and the SARS-CoV-2 receptor binding domain (RBD)-angiotensin-converting enzyme 2 (ACE2) complex of SARS-CoV-2. PC786, an antiviral polymerase inhibitor, showed enhanced binding affinity to all the targets. Furthermore, the postfusion conformation of the trimeric S protein RBD with ACE2 revealed conformational changes associated with PC786 drug binding. Exploiting immunoinformatics to identify T cell and B cell epitopes could guide future experimental studies with a higher probability of discovering appropriate vaccine candidates with fewer experiments and higher reliability.", "doi": "10.1126/sciadv.abb8097", "pmid": "32691011", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Imaging": null}, "xrefs": [{"db": "pii", "key": "abb8097"}, {"db": "pmc", "key": "PMC7319274"}], "notes": [], "created": "2020-11-22T09:29:59.106Z", "modified": "2021-02-26T08:45:36.642Z"}, {"entity": "publication", "iuid": "0c693dbf11714aedb01adc0574874d49", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c693dbf11714aedb01adc0574874d49.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c693dbf11714aedb01adc0574874d49"}}, "title": "Severe maternal morbidity and mortality associated with COVID-19: The risk should not be downplayed.", "authors": [{"family": "Westgren", "given": "Magnus", "initials": "M"}, {"family": "Pettersson", "given": "Karin", "initials": "K"}, {"family": "Hagberg", "given": "Henrik", "initials": "H"}, {"family": "Acharya", "given": "Ganesh", "initials": "G"}], "type": "editorial", "published": "2020-07-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "7", "pages": "815-816", "issn-l": "0001-6349"}, "abstract": "Editorial", "doi": "10.1111/aogs.13900", "pmid": "32386440", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7273078"}], "notes": [], "created": "2020-11-25T07:50:33.073Z", "modified": "2020-12-10T07:44:28.141Z"}, {"entity": "publication", "iuid": "50ccecd135cf4a93bfc0e8d922c54278", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50ccecd135cf4a93bfc0e8d922c54278.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50ccecd135cf4a93bfc0e8d922c54278"}}, "title": "Rapid risk assessment from ECDC: Resurgence of reported cases of COVID-19 in the EU/EEA, the UK and EU candidate and potential candidate countries.", "authors": [{"family": "Eurosurveillance editorial team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "26", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.26.2007021", "pmid": "32643600", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7346365"}], "notes": [], "created": "2020-12-08T14:30:09.784Z", "modified": "2020-12-08T14:30:19.350Z"}, {"entity": "publication", "iuid": "5885b52cf6834f5dab52e3606ffac54e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5885b52cf6834f5dab52e3606ffac54e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5885b52cf6834f5dab52e3606ffac54e"}}, "title": "Public Health Agency of Sweden's Brief Report: Pregnant and postpartum women with severe acute respiratory syndrome coronavirus 2 infection in intensive care in Sweden.", "authors": [{"family": "Collin", "given": "Julius", "initials": "J"}, {"family": "Bystr\u00f6m", "given": "Emma", "initials": "E"}, {"family": "Carnahan", "given": "AnnaSara", "initials": "A"}, {"family": "Ahrne", "given": "Malin", "initials": "M"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "7", "pages": "819-822", "issn-l": "0001-6349"}, "abstract": "The Public Health Agency of Sweden has analyzed how many pregnant and postpartum women with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been treated in intensive care units (ICU) in Sweden between 19 March and 20 April 2020 compared with non-pregnant women of similar age. Cases were identified in a special reporting module within the Swedish Intensive Care Registry (SIR). Fifty-three women aged 20-45 years with SARS-CoV-2 were reported in SIR, and 13 of these women were either pregnant or postpartum (<1 week). The results indicate that the risk of being admitted to ICU may be higher in pregnant and postpartum women with laboratory-confirmed SARS-CoV-2 in Sweden, compared with non-pregnant women of similar age.", "doi": "10.1111/aogs.13901", "pmid": "32386441", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7273089"}], "notes": [], "created": "2020-12-10T07:58:07.980Z", "modified": "2021-02-26T08:45:48.195Z"}, {"entity": "publication", "iuid": "50c6a161919c4123b26f46a4f9663d4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50c6a161919c4123b26f46a4f9663d4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50c6a161919c4123b26f46a4f9663d4d"}}, "title": "Perspective: COVID-19, implications of nasal diseases and consequences for their management.", "authors": [{"family": "Jian", "given": "Li", "initials": "L"}, {"family": "Yi", "given": "Wei", "initials": "W"}, {"family": "Zhang", "given": "Nan", "initials": "N"}, {"family": "Wen", "given": "Weiping", "initials": "W"}, {"family": "Krysko", "given": "Olga", "initials": "O"}, {"family": "Song", "given": "Woo-Jung", "initials": "W"}, {"family": "Bachert", "given": "Claus", "initials": "C"}], "type": "editorial", "published": "2020-07-00", "journal": {"title": "J Allergy Clin Immunol", "issn": "1097-6825", "volume": "146", "issue": "1", "pages": "67-69", "issn-l": "0091-6749"}, "abstract": "Editorial", "doi": "10.1016/j.jaci.2020.04.030", "pmid": "32360869", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0091-6749(20)30625-4"}, {"db": "pmc", "key": "PMC7252138"}], "notes": [], "created": "2020-11-25T07:19:54.341Z", "modified": "2020-12-10T07:24:26.859Z"}, {"entity": "publication", "iuid": "a64f9d7c657f4b8188082ecd258c7b56", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a64f9d7c657f4b8188082ecd258c7b56.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a64f9d7c657f4b8188082ecd258c7b56"}}, "title": "Our Experience of Trauma Management During Novel Coronovirus 2019 (COVID-19) Pandemic in a Busy Trauma Center in Southern Iran.", "authors": [{"family": "Akbarialiabad", "given": "Hossein", "initials": "H"}, {"family": "Abdolrahimzadeh Fard", "given": "Hossein", "initials": "H"}, {"family": "Abbasi", "given": "Hamid Reza", "initials": "HR"}, {"family": "Bolandparvaz", "given": "Shahram", "initials": "S"}, {"family": "Mohseni", "given": "Shahin", "initials": "S"}, {"family": "Mehrnous", "given": "Vahid", "initials": "V"}, {"family": "Saleh", "given": "Mina", "initials": "M"}, {"family": "Roushenas", "given": "Sima", "initials": "S"}, {"family": "Paydar", "given": "Shahram", "initials": "S"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Bull Emerg Trauma", "issn": "2322-2522", "volume": "8", "issue": "3", "pages": "199-201", "issn-l": null}, "abstract": "During the past few months, the novel coronavirus 2019 (COVID-19) pandemic has significantly affected medical service provision. In Iran, it has caused around 197,000 inflictions and 9200 deaths up to June 18, 2020. While many departments turned to telehealth in this era, the trauma service should provide non-stop in presence service to the trauma victims. Our trauma center is the largest in the southwest of Iran, with the mean annual admission of 18,500 polytrauma patients. In this center, we designed a safety protocol to mitigate the spread of disease and also have a more robust case finding system, especially among asymptomatic carriers who attend hospitals based on their trauma. In brief, all unstable patients were considered SARS-COV-2 positive and were directed toward the Specialized COVID-19 related ICU. For all stable patients, history, physical examination, CXR, and lab test (Complete Blood Count, Erythrocyte Sedimentation Rate, C-Reactive Protein) were ordered before entering the wards. If there was any suspicion of COVID-19, the stable patient was admitted to the COVID-19 specialized ward. Among all 1805 patients admitted during a ten weeks interval (from January 30, 2020, to April 14, 2020), 84 had a red flag and toward to COVID-19 related wards. Of those, 67 had positive PCR or evidence in CT in favor of the COOVID-19. Moreover, during regular workups, we found that 19 completely asymptomatic trauma victims had typical Chest CT scan findings of COVID-19.", "doi": "10.30476/BEAT.2020.87029", "pmid": "32944581", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7468226"}], "notes": [], "created": "2020-12-03T15:27:34.904Z", "modified": "2021-02-26T08:45:48.547Z"}, {"entity": "publication", "iuid": "021965c398864f9b8c7a42d09c6b08d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/021965c398864f9b8c7a42d09c6b08d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/021965c398864f9b8c7a42d09c6b08d0"}}, "title": "Oncology during the COVID-19 pandemic: challenges, dilemmas and the psychosocial impact on cancer patients.", "authors": [{"family": "Tsamakis", "given": "Konstantinos", "initials": "K"}, {"family": "Gavriatopoulou", "given": "Maria", "initials": "M"}, {"family": "Schizas", "given": "Dimitrios", "initials": "D"}, {"family": "Stravodimou", "given": "Athina", "initials": "A"}, {"family": "Mougkou", "given": "Aikaterini", "initials": "A"}, {"family": "Tsiptsios", "given": "Dimitrios", "initials": "D"}, {"family": "Sioulas", "given": "Vasileios", "initials": "V"}, {"family": "Spartalis", "given": "Eleftherios", "initials": "E"}, {"family": "Sioulas", "given": "Athanasios D", "initials": "AD"}, {"family": "Tsamakis", "given": "Charalampos", "initials": "C"}, {"family": "Charalampakis", "given": "Nikolaos", "initials": "N"}, {"family": "Mueller", "given": "Christoph", "initials": "C"}, {"family": "Arya", "given": "Donna", "initials": "D"}, {"family": "Zarogoulidis", "given": "Paul", "initials": "P"}, {"family": "Spandidos", "given": "Demetrios A", "initials": "DA"}, {"family": "Dimopoulos", "given": "Meletios A", "initials": "MA"}, {"family": "Papageorgiou", "given": "Charalabos", "initials": "C"}, {"family": "Rizos", "given": "Emmanouil", "initials": "E"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Oncol Lett", "issn": "1792-1074", "volume": "20", "issue": "1", "pages": "441-447", "issn-l": null}, "abstract": "COVID-19 has caused unprecedented societal turmoil, triggering a rapid, still ongoing, transformation of healthcare provision on a global level. In this new landscape, it is highly important to acknowledge the challenges this pandemic poses on the care of the particularly vulnerable cancer patients and the subsequent psychosocial impact on them. We have outlined our clinical experience in managing patients with gastrointestinal, hematological, gynaecological, dermatological, neurological, thyroid, lung and paediatric cancers in the COVID-19 era and have reviewed the emerging literature around barriers to care of oncology patients and how this crisis affects them. Moreover, evolving treatment strategies and novel ways of addressing the needs of oncology patients in the new context of the pandemic are discussed.", "doi": "10.3892/ol.2020.11599", "pmid": "32565968", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "OL-0-0-11599"}, {"db": "pmc", "key": "PMC7285823"}], "notes": [], "created": "2020-11-26T12:16:52.516Z", "modified": "2020-11-30T08:59:19.190Z"}, {"entity": "publication", "iuid": "e8b6bd1ad99e460ca94575c9f0f8a8bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e8b6bd1ad99e460ca94575c9f0f8a8bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e8b6bd1ad99e460ca94575c9f0f8a8bd"}}, "title": "Obstetric and intensive-care strategies in a high-risk pregnancy with critical respiratory failure due to COVID-19: A case report.", "authors": [{"family": "Kolkova", "given": "Zuzana", "initials": "Z"}, {"family": "Bjurstr\u00f6m", "given": "Martin F", "initials": "MF"}, {"family": "L\u00e4nsberg", "given": "John-Kalle", "initials": "JK"}, {"family": "Svedas", "given": "Eimantas", "initials": "E"}, {"family": "Hamer", "given": "Maria Andrada", "initials": "MA"}, {"family": "Hansson", "given": "Stefan R", "initials": "SR"}, {"family": "Herbst", "given": "Andreas", "initials": "A"}, {"family": "Zaigham", "given": "Mehreen", "initials": "M"}], "type": "case reports", "published": "2020-07-00", "journal": {"title": "Case Rep Womens Health", "issn": "2214-9112", "volume": "27", "issue": null, "pages": "e00240", "issn-l": null}, "abstract": "With the disease burden increasing daily, there is a lack of evidence regarding the impact of COVID-19 in pregnancy. Healthy pregnant women are still not regarded as a susceptible group despite physiological changes that make pregnant women more vulnerable to severe infection. However, high-risk pregnancies may be associated with severe COVID-19 disease with respiratory failure, as outlined in this report. We discuss the importance of timely delivery and antenatal steroid administration in a critically ill patient.\n\nA 27-year-old pregnant woman (gravida 2, para 1) with type I diabetes, morbid obesity, hypothyroidism and a previous Caesarean section presented with critical respiratory failure secondary to COVID-19 at 32 weeks of gestation. A preterm emergency Caesarean section was performed, after steroid treatment for foetal lung maturation. The patient benefited from prone positioning; however, transient acute renal injury, rhabdomyolysis and sepsis led to prolonged intensive care and mechanical ventilation for 30 days. The baby had an uncomplicated recovery.\n\nCOVID-19 infection in high-risk pregnancies may result in severe maternal and neonatal outcomes such as critical respiratory failure requiring mechanical ventilation and premature termination of the pregnancy. Antenatal steroids may be of benefit for foetal lung maturation but should not delay delivery in severe cases.", "doi": "10.1016/j.crwh.2020.e00240", "pmid": "32714844", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2214-9112(20)30070-9"}, {"db": "pii", "key": "e00240"}, {"db": "pmc", "key": "PMC7340590"}], "notes": [], "created": "2020-12-07T16:13:01.929Z", "modified": "2021-02-26T08:45:48.823Z"}, {"entity": "publication", "iuid": "54f00ae9073c40afbf775f85fbaa23ac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54f00ae9073c40afbf775f85fbaa23ac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54f00ae9073c40afbf775f85fbaa23ac"}}, "title": "Multimodality Cardiovascular Imaging in the Midst of the COVID-19 Pandemic: Ramping Up Safely to a New Normal.", "authors": [{"family": "Zoghbi", "given": "William A", "initials": "WA"}, {"family": "DiCarli", "given": "Marcelo F", "initials": "MF"}, {"family": "Blankstein", "given": "Ron", "initials": "R"}, {"family": "Choi", "given": "Andrew D", "initials": "AD"}, {"family": "Dilsizian", "given": "Vasken", "initials": "V"}, {"family": "Flachskampf", "given": "Frank A", "initials": "FA"}, {"family": "Geske", "given": "Jeffrey B", "initials": "JB"}, {"family": "Grayburn", "given": "Paul A", "initials": "PA"}, {"family": "Jaffer", "given": "Farouc A", "initials": "FA"}, {"family": "Kwong", "given": "Raymond Y", "initials": "RY"}, {"family": "Leipsic", "given": "Jonathan A", "initials": "JA"}, {"family": "Marwick", "given": "Thomas H", "initials": "TH"}, {"family": "Nagel", "given": "Eike", "initials": "E"}, {"family": "Nieman", "given": "Koen", "initials": "K"}, {"family": "Raman", "given": "Subha V", "initials": "SV"}, {"family": "Salerno", "given": "Michael", "initials": "M"}, {"family": "Sengupta", "given": "Partho P", "initials": "PP"}, {"family": "Shaw", "given": "Leslee J", "initials": "LJ"}, {"family": "Chandrashekhar", "given": "Y S", "initials": "YS"}, {"family": "ACC Imaging Council", "given": "", "initials": ""}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "JACC Cardiovasc Imaging", "issn": "1876-7591", "volume": "13", "issue": "7", "pages": "1615-1626", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jcmg.2020.06.001", "pmid": "32646721", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1936-878X(20)30474-5"}, {"db": "pmc", "key": "PMC7290215"}], "notes": [], "created": "2020-11-30T08:51:25.555Z", "modified": "2020-11-30T08:51:25.580Z"}, {"entity": "publication", "iuid": "5fa587f8610347dca914e98d020b66eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5fa587f8610347dca914e98d020b66eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5fa587f8610347dca914e98d020b66eb"}}, "title": "Multidisciplinary research priorities for the COVID-19 pandemic - Authors' reply.", "authors": [{"family": "O'Connor", "given": "Rory C", "initials": "RC"}, {"family": "Hotopf", "given": "Matthew", "initials": "M"}, {"family": "Worthman", "given": "Carol M", "initials": "CM"}, {"family": "Perry", "given": "V Hugh", "initials": "VH"}, {"family": "Tracey", "given": "Irene", "initials": "I"}, {"family": "Wessely", "given": "Simon", "initials": "S"}, {"family": "Arseneault", "given": "Louise", "initials": "L"}, {"family": "Ballard", "given": "Clive", "initials": "C"}, {"family": "Christensen", "given": "Helen", "initials": "H"}, {"family": "Silver", "given": "Roxane Cohen", "initials": "RC"}, {"family": "Ford", "given": "Tamsin", "initials": "T"}, {"family": "John", "given": "Ann", "initials": "A"}, {"family": "Kabir", "given": "Thomas", "initials": "T"}, {"family": "King", "given": "Kate", "initials": "K"}, {"family": "Simpson", "given": "Alan", "initials": "A"}, {"family": "Madan", "given": "Ira", "initials": "I"}, {"family": "Cowan", "given": "Katherine", "initials": "K"}, {"family": "Bullmore", "given": "Ed", "initials": "E"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}], "type": "letter", "published": "2020-07-00", "journal": {"title": "Lancet Psychiatry", "issn": "2215-0374", "volume": "7", "issue": "7", "pages": "e44-e45", "issn-l": "2215-0366"}, "abstract": null, "doi": "10.1016/S2215-0366(20)30247-9", "pmid": "32563319", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2215-0366(20)30247-9"}, {"db": "pmc", "key": "PMC7302786"}], "notes": [], "created": "2020-11-19T19:34:04.325Z", "modified": "2020-12-08T16:42:41.940Z"}, {"entity": "publication", "iuid": "7ec0b821c62c47adb1d094adfc266824", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7ec0b821c62c47adb1d094adfc266824.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7ec0b821c62c47adb1d094adfc266824"}}, "title": "Monoclonal antibodies for the S2 subunit of spike of SARS-CoV-1 cross-react with the newly-emerged SARS-CoV-2.", "authors": [{"family": "Zheng", "given": "Zhiqiang", "initials": "Z"}, {"family": "Monteil", "given": "Vanessa Marthe", "initials": "VM"}, {"family": "Maurer-Stroh", "given": "Sebastian", "initials": "S"}, {"family": "Yew", "given": "Chow Wenn", "initials": "CW"}, {"family": "Leong", "given": "Carol", "initials": "C"}, {"family": "Mohd-Ismail", "given": "Nur Khairiah", "initials": "NK"}, {"family": "Cheyyatraivendran Arularasu", "given": "Suganya", "initials": "S"}, {"family": "Chow", "given": "Vincent Tak Kwong", "initials": "VTK"}, {"family": "Lin", "given": "Raymond Tzer Pin", "initials": "RTP"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Hong", "given": "Wanjin", "initials": "W"}, {"family": "Tan", "given": "Yee-Joo", "initials": "YJ"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "28", "issn-l": null}, "abstract": "BackgroundA novel coronavirus, SARS-CoV-2, which emerged at the end of 2019 and causes COVID-19, has resulted in worldwide human infections. While genetically distinct, SARS-CoV-1, the aetiological agent responsible for an outbreak of severe acute respiratory syndrome (SARS) in 2002-2003, utilises the same host cell receptor as SARS-CoV-2 for entry: angiotensin-converting enzyme 2 (ACE2). Parts of the SARS-CoV-1 spike glycoprotein (S protein), which interacts with ACE2, appear conserved in SARS-CoV-2.AimThe cross-reactivity with SARS-CoV-2 of monoclonal antibodies (mAbs) previously generated against the S protein of SARS-CoV-1 was assessed.MethodsThe SARS-CoV-2 S protein sequence was aligned to those of SARS-CoV-1, Middle East respiratory syndrome (MERS) and common-cold coronaviruses. Abilities of mAbs generated against SARS-CoV-1 S protein to bind SARS-CoV-2 or its S protein were tested with SARS-CoV-2 infected cells as well as cells expressing either the full length protein or a fragment of its S2 subunit. Quantitative ELISA was also performed to compare binding of mAbs to recombinant S protein.ResultsAn immunogenic domain in the S2 subunit of SARS-CoV-1 S protein is highly conserved in SARS-CoV-2 but not in MERS and human common-cold coronaviruses. Four murine mAbs raised against this immunogenic fragment could recognise SARS-CoV-2 S protein expressed in mammalian cell lines. In particular, mAb 1A9 was demonstrated to detect S protein in SARS-CoV-2-infected cells and is suitable for use in a sandwich ELISA format.ConclusionThe cross-reactive mAbs may serve as useful tools for SARS-CoV-2 research and for the development of diagnostic assays for COVID-19.", "doi": "10.2807/1560-7917.ES.2020.25.28.2000291", "pmid": "32700671", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Imaging": null}, "xrefs": [{"db": "pmc", "key": "PMC7376845"}], "notes": [], "created": "2020-12-07T16:22:09.955Z", "modified": "2021-02-26T08:45:36.612Z"}, {"entity": "publication", "iuid": "180b7ff648b8487f9227b1bee6cb8526", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/180b7ff648b8487f9227b1bee6cb8526.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/180b7ff648b8487f9227b1bee6cb8526"}}, "title": "Mobile Health Technology for Enhancing the COVID-19 Response in Africa: A Potential Game Changer?", "authors": [{"family": "Nachega", "given": "Jean B", "initials": "JB"}, {"family": "Leisegang", "given": "Rory", "initials": "R"}, {"family": "Kallay", "given": "Oscar", "initials": "O"}, {"family": "Mills", "given": "Edward J", "initials": "EJ"}, {"family": "Zumla", "given": "Alimuddin", "initials": "A"}, {"family": "Lester", "given": "Richard T", "initials": "RT"}], "type": "editorial", "published": "2020-07-00", "journal": {"title": "Am J Trop Med Hyg", "issn": "1476-1645", "volume": "103", "issue": "1", "pages": "3-5", "issn-l": "0002-9637"}, "abstract": null, "doi": "10.4269/ajtmh.20-0506", "pmid": "32476643", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7356462"}], "notes": [], "created": "2020-11-19T14:52:44.187Z", "modified": "2020-12-09T10:56:27.358Z"}, {"entity": "publication", "iuid": "da8d6c9ff2114a42b5988ab677cadb37", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/da8d6c9ff2114a42b5988ab677cadb37.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/da8d6c9ff2114a42b5988ab677cadb37"}}, "title": "Maternal mental health in the time of the COVID-19 pandemic.", "authors": [{"family": "Thapa", "given": "Suraj B", "initials": "SB"}, {"family": "Mainali", "given": "Anustha", "initials": "A"}, {"family": "Schwank", "given": "Simone E", "initials": "SE"}, {"family": "Acharya", "given": "Ganesh", "initials": "G"}], "type": "editorial", "published": "2020-07-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "7", "pages": "817-818", "issn-l": "0001-6349"}, "abstract": null, "doi": "10.1111/aogs.13894", "pmid": "32374420", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7267371"}], "notes": [], "created": "2020-12-10T07:33:05.949Z", "modified": "2020-12-10T07:35:13.106Z"}, {"entity": "publication", "iuid": "2151e438279c4482b86b2b0c8239b4a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2151e438279c4482b86b2b0c8239b4a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2151e438279c4482b86b2b0c8239b4a4"}}, "title": "Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies.", "authors": [{"family": "Zaigham", "given": "Mehreen", "initials": "M"}, {"family": "Andersson", "given": "Ola", "initials": "O"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "7", "pages": "823-829", "issn-l": "0001-6349"}, "abstract": "The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has exposed vulnerable populations to an unprecedented global health crisis. The knowledge gained from previous human coronavirus outbreaks suggests that pregnant women and their fetuses are particularly susceptible to poor outcomes. The objective of this study was to summarize the clinical manifestations and maternal and perinatal outcomes of COVID-19 during pregnancy.\n\nWe searched databases for all case reports and series from 12 February to 4 April 2020. Multiple terms and combinations were used including COVID-19, pregnancy, maternal mortality, maternal morbidity, complications, clinical manifestations, neonatal morbidity, intrauterine fetal death, neonatal mortality and SARS-CoV-2. Eligibility criteria included peer-reviewed publications written in English or Chinese and quantitative real-time polymerase chain reaction (PCR) or dual fluorescence PCR-confirmed SARS-CoV-2 infection. Unpublished reports, unspecified date and location of the study or suspicion of duplicate reporting, cases with suspected COVID-19 that were not confirmed by a laboratory test, and unreported maternal or perinatal outcomes were excluded. Data on clinical manifestations, maternal and perinatal outcomes including vertical transmission were extracted and analyzed.\n\nEighteen articles reporting data from 108 pregnancies between 8 December 2019 and 1 April 2020 were included in the current study. Most reports described women presenting in the third trimester with fever (68%) and coughing (34%). Lymphocytopenia (59%) with elevated C-reactive protein (70%) was observed and 91% of the women were delivered by cesarean section. Three maternal intensive care unit admissions were noted but no maternal deaths. One neonatal death and one intrauterine death were also reported.\n\nAlthough the majority of mothers were discharged without any major complications, severe maternal morbidity as a result of COVID-19 and perinatal deaths were reported. Vertical transmission of the COVID-19 could not be ruled out. Careful monitoring of pregnancies with COVID-19 and measures to prevent neonatal infection are warranted.", "doi": "10.1111/aogs.13867", "pmid": "32259279", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7262097"}], "notes": [], "created": "2020-11-30T15:55:39.008Z", "modified": "2020-11-30T15:55:39.021Z"}, {"entity": "publication", "iuid": "96eef9ada9a44102903b21f3f0ac210b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/96eef9ada9a44102903b21f3f0ac210b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/96eef9ada9a44102903b21f3f0ac210b"}}, "title": "Management of a COVID-19 outbreak in a hotel in Tenerife, Spain.", "authors": [{"family": "Hoefer", "given": "Andreas", "initials": "A"}, {"family": "Pampaka", "given": "Despina", "initials": "D"}, {"family": "Rivas Wagner", "given": "Eva", "initials": "E"}, {"family": "Alem\u00e1n Herrera", "given": "Araceli", "initials": "A"}, {"family": "Garc\u00eda-Ramos Alonso", "given": "Eduardo", "initials": "E"}, {"family": "L\u00f3pez-Perea", "given": "Noem\u00ed", "initials": "N"}, {"family": "Cano Portero", "given": "Rosa", "initials": "R"}, {"family": "Herrera-Le\u00f3n", "given": "Laura", "initials": "L"}, {"family": "Herrera-Le\u00f3n", "given": "Silvia", "initials": "S"}, {"family": "N\u00fa\u00f1ez Gallo", "given": "Domingo", "initials": "D"}], "type": "case reports", "published": "2020-07-00", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": "96", "issue": null, "pages": "384-386"}, "abstract": "Since the first accounts of SARS-CoV-2, authorities have encountered numerous unprecedented situations threatening public health. This rapid communication addresses events that led to the quarantining of a hotel in Tenerife, Spain and the effectiveness of the rapidly implemented control measures. In total, eight cases have been associated with the hotel. Due to the international nature of the guests, had these timely precautions not been in place, a multinational cluster might have formed.", "doi": "10.1016/j.ijid.2020.05.047", "pmid": "32425635", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(20)30354-4"}, {"db": "pmc", "key": "PMC7231486"}], "notes": [], "created": "2020-12-09T11:43:15.406Z", "modified": "2020-12-09T11:43:54.389Z"}, {"entity": "publication", "iuid": "b8f85e06a4644e5c9870905c0125d822", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8f85e06a4644e5c9870905c0125d822.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8f85e06a4644e5c9870905c0125d822"}}, "title": "International expert consensus statement regarding radiotherapy treatment options for rectal cancer during the COVID 19 pandemic.", "authors": [{"family": "Marijnen", "given": "C A M", "initials": "CAM"}, {"family": "Peters", "given": "F P", "initials": "FP"}, {"family": "R\u00f6del", "given": "C", "initials": "C"}, {"family": "Bujko", "given": "K", "initials": "K"}, {"family": "Haustermans", "given": "K", "initials": "K"}, {"family": "Fokas", "given": "E", "initials": "E"}, {"family": "Glynne-Jones", "given": "R", "initials": "R"}, {"family": "Valentini", "given": "V", "initials": "V"}, {"family": "Spindler", "given": "K-L G", "initials": "KG"}, {"family": "Guren", "given": "M G", "initials": "MG"}, {"family": "Maingon", "given": "Philippe", "initials": "P"}, {"family": "Calvo", "given": "F A", "initials": "FA"}, {"family": "Pares", "given": "O", "initials": "O"}, {"family": "Glimelius", "given": "B", "initials": "B"}, {"family": "Sebag-Montefiore", "given": "D", "initials": "D"}], "type": "letter", "published": "2020-07-00", "journal": {"title": "Radiother Oncol", "issn": "1879-0887", "volume": "148", "issue": null, "pages": "213-215", "issn-l": "0167-8140"}, "abstract": null, "doi": "10.1016/j.radonc.2020.03.039", "pmid": "32342861", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0167-8140(20)30173-0"}, {"db": "pmc", "key": "PMC7194592"}], "notes": [], "created": "2020-12-10T07:14:52.505Z", "modified": "2020-12-10T07:16:00.513Z"}, {"entity": "publication", "iuid": "ec472b86cef64d62be6ea9374a1da38d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec472b86cef64d62be6ea9374a1da38d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec472b86cef64d62be6ea9374a1da38d"}}, "title": "International Organization for the Study of IBD Recommendations for Surgery in Patients With IBD During the Coronavirus Disease 2019 Pandemic.", "authors": [{"family": "Remzi", "given": "Feza H", "initials": "FH"}, {"family": "Panis", "given": "Yves", "initials": "Y"}, {"family": "Spinelli", "given": "Antonino", "initials": "A"}, {"family": "Kotze", "given": "Paulo G", "initials": "PG"}, {"family": "Mantzaris", "given": "Gerassimos", "initials": "G"}, {"family": "S\u00f6derholm", "given": "Johan D", "initials": "JD"}, {"family": "d'Hoore", "given": "Andr\u00e9", "initials": "A"}, {"family": "Bemelman", "given": "Willem A", "initials": "WA"}, {"family": "Yamamoto", "given": "Takayuki", "initials": "T"}, {"family": "Pemberton", "given": "John H", "initials": "JH"}, {"family": "Tiret", "given": "Emmanuel", "initials": "E"}, {"family": "\u00d8resland", "given": "Tom", "initials": "T"}, {"family": "Fleshner", "given": "Phillip", "initials": "P"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Dis Colon Rectum", "issn": "1530-0358", "volume": "63", "issue": "7", "pages": "870-873", "issn-l": null}, "abstract": null, "doi": "10.1097/DCR.0000000000001718", "pmid": "32355056", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-10T07:16:56.833Z", "modified": "2020-12-10T07:17:39.381Z"}, {"entity": "publication", "iuid": "0179eb6762e54a4ca86be4f91c1ebc5d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0179eb6762e54a4ca86be4f91c1ebc5d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0179eb6762e54a4ca86be4f91c1ebc5d"}}, "title": "Impact of COVID-19 on Prostate Cancer Management: Guidelines for Urologists.", "authors": [{"family": "Dovey", "given": "Zachary", "initials": "Z"}, {"family": "Mohamed", "given": "Nihal", "initials": "N"}, {"family": "Gharib", "given": "Yasmine", "initials": "Y"}, {"family": "Ratnani", "given": "Parita", "initials": "P"}, {"family": "Hammouda", "given": "Nada", "initials": "N"}, {"family": "Nair", "given": "Sujit S", "initials": "SS"}, {"family": "Chakravarty", "given": "Dimple", "initials": "D"}, {"family": "Sobotka", "given": "Stanislaw", "initials": "S"}, {"family": "Lantz", "given": "Anna", "initials": "A"}, {"family": "Wiklund", "given": "Peter", "initials": "P"}, {"family": "Kyprianou", "given": "Natasha", "initials": "N"}, {"family": "Tewari", "given": "Ash", "initials": "A"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Eur Urol Open Sci", "issn": "2666-1683", "volume": "20", "pages": "1-11", "issn-l": null}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has resulted in a global health emergency, the like of which has never been seen before. Prostate cancer (PCa) services across the globe have been on hold due to changing medical and surgical priorities. There is also epidemiological evidence that PCa patients have increased incidence and mortality from SARS-CoV-2 infection due to gender differences, age, and higher propensity for risk factors (eg, respiratory disease, obesity, hypertension, and smoking status).\n\nTo contribute to the emerging body of knowledge on the risks of SARS-CoV-2 infection to PCa patients and, in the face of PCa treatment delays, provide evidence-based recommendations for ongoing management of specific PCa patient groups.\n\nA literature search was performed using all sources (MEDLINE, EMBASE, ScienceDirect, Cochrane Libraries, and Web of Science) as well as the media to harness emerging data on the SARS-CoV-2 pandemic and its influence on PCa. Eligibility criteria were originality of data and relevance to PCa management. The authors note that during these unprecedented times, retrospective data are constantly being updated from multiple sources globally.\n\nA total of 72 articles and data sources were found initially. Owing to repetition, lack of originality, or nonrelevance, six articles were rejected, leaving 23 retrospective studies, seven basic science research articles, 15 societal and journal guidelines, and 21 epidemiological data sources, from countries at different stages of SARS-CoV-2 pandemic. These were analyzed qualitatively to produce evidence-based guidelines for the management of PCa patients at different stages of the patient journey, with strategies to reduce the risk of viral spread.\n\nPCa patients may have an increased risk of SARS-CoV-2 infection as well as morbidity and mortality if infected. Once appropriately triaged, and to reduce viral spread, PCa patients can have surveillance by telemedicine, and institute lifestyle changes and social quarantining measures. If risk stratification suggests that treatment should be planned, androgen deprivation therapy can be started, or potentially surgery or radiation therapy is possible on a case-by-case basis.\n\nProstate cancer patients can be followed up remotely until the severe acute respiratory syndrome coronavirus 2 pandemic resolves, but higher-risk cases may have treatment expedited to limit any negative impact on prostate cancer outcomes.", "doi": "10.1016/j.euros.2020.05.005", "pmid": "34173542", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2666-1683(20)35112-0"}, {"db": "pmc", "key": "PMC7296308"}], "notes": [], "created": "2021-06-28T18:10:08.713Z", "modified": "2021-06-28T18:10:08.739Z"}, {"entity": "publication", "iuid": "f696e692cb204174b59deef6989d8d6a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f696e692cb204174b59deef6989d8d6a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f696e692cb204174b59deef6989d8d6a"}}, "title": "Illegal Online Sexual Behavior During the COVID-19 Pandemic: A Call for Action Based on Experiences From the Ongoing Prevent It Research Study.", "authors": [{"family": "Parks", "given": "Allison", "initials": "A"}, {"family": "Sparre", "given": "Charlotte", "initials": "C"}, {"family": "S\u00f6derquist", "given": "Elin", "initials": "E"}, {"family": "Arver", "given": "Stefan", "initials": "S"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Kaldo", "given": "Viktor", "initials": "V"}, {"family": "G\u00f6rts-\u00d6berg", "given": "Katarina", "initials": "K"}, {"family": "Rahm", "given": "Christoffer", "initials": "C"}], "type": "letter", "published": "2020-07-00", "journal": {"title": "Arch Sex Behav", "issn": "1573-2800", "issn-l": "0004-0002", "volume": "49", "issue": "5", "pages": "1433-1435"}, "abstract": null, "doi": "10.1007/s10508-020-01750-7", "pmid": "32488645", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10508-020-01750-7"}, {"db": "pmc", "key": "PMC7266414"}], "notes": [], "created": "2020-11-25T09:30:06.115Z", "modified": "2020-12-11T12:58:18.631Z"}, {"entity": "publication", "iuid": "13ebcfe1236a492abaaf8d03a0b655b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13ebcfe1236a492abaaf8d03a0b655b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13ebcfe1236a492abaaf8d03a0b655b0"}}, "title": "Handling of allergen immunotherapy in the COVID-19 pandemic: An ARIA-EAACI statement.", "authors": [{"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Jutel", "given": "Marek", "initials": "M"}, {"family": "Akdis", "given": "Cezmi", "initials": "C"}, {"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Akdis", "given": "M\u00fcbeccel", "initials": "M"}, {"family": "Bachert", "given": "Claus", "initials": "C"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Ansotegui", "given": "Ignacio", "initials": "I"}, {"family": "Bedbrook", "given": "Anna", "initials": "A"}, {"family": "Bosnic-Anticevich", "given": "Sinthia", "initials": "S"}, {"family": "Canonica", "given": "Giorgio W", "initials": "GW"}, {"family": "Chivato", "given": "Tomas", "initials": "T"}, {"family": "Cruz", "given": "Alvaro A", "initials": "AA"}, {"family": "Czarlewski", "given": "Wienia", "initials": "W"}, {"family": "Del Giacco", "given": "Stefano", "initials": "S"}, {"family": "Du", "given": "Hui", "initials": "H"}, {"family": "Fonseca", "given": "Joao A", "initials": "JA"}, {"family": "Gao", "given": "Yadong", "initials": "Y"}, {"family": "Haahtela", "given": "Tari", "initials": "T"}, {"family": "Hoffmann-Sommergruber", "given": "Karin", "initials": "K"}, {"family": "Ivancevich", "given": "Juan-Carlos", "initials": "J"}, {"family": "Khaltaev", "given": "Nikolai", "initials": "N"}, {"family": "Knol", "given": "Edward F", "initials": "EF"}, {"family": "Kuna", "given": "Piotr", "initials": "P"}, {"family": "Larenas-Linnemann", "given": "Desiree", "initials": "D"}, {"family": "Melen", "given": "Erik", "initials": "E"}, {"family": "Mullol", "given": "Joaquim", "initials": "J"}, {"family": "Naclerio", "given": "Robert", "initials": "R"}, {"family": "Ohta", "given": "Ken", "initials": "K"}, {"family": "Okamoto", "given": "Yoshitaka", "initials": "Y"}, {"family": "O'Mahony", "given": "Liam", "initials": "L"}, {"family": "Onorato", "given": "Gabrielle L", "initials": "GL"}, {"family": "Papadopoulos", "given": "Nikos G", "initials": "NG"}, {"family": "Pawankar", "given": "Ruby", "initials": "R"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Samolinski", "given": "Boleslaw", "initials": "B"}, {"family": "Schwarze", "given": "Jurgen", "initials": "J"}, {"family": "Toppila-Salmi", "given": "Sanna", "initials": "S"}, {"family": "Shamji", "given": "Mohamed H", "initials": "MH"}, {"family": "Teresa Ventura", "given": "Maria", "initials": "M"}, {"family": "Valiulis", "given": "Arunas", "initials": "A"}, {"family": "Yorgancioglu", "given": "Arzu", "initials": "A"}, {"family": "Matricardi", "given": "Paolo", "initials": "P"}, {"family": "Zuberbier", "given": "Torsten", "initials": "T"}, {"family": "ARIA-MASK Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": "75", "issue": "7", "pages": "1546-1554", "issn-l": "0105-4538"}, "abstract": null, "doi": "10.1111/all.14336", "pmid": "32329930", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7264744"}], "notes": [], "created": "2020-11-23T11:47:55.525Z", "modified": "2020-11-23T11:48:33.320Z"}, {"entity": "publication", "iuid": "7156626f870e4e5987ce1779717d55b5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7156626f870e4e5987ce1779717d55b5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7156626f870e4e5987ce1779717d55b5"}}, "title": "Excess all-cause mortality during the COVID-19 pandemic in Europe - preliminary pooled estimates from the EuroMOMO network, March to April 2020.", "authors": [{"family": "Vestergaard", "given": "Lasse S", "initials": "LS"}, {"family": "Nielsen", "given": "Jens", "initials": "J"}, {"family": "Richter", "given": "Lukas", "initials": "L"}, {"family": "Schmid", "given": "Daniela", "initials": "D"}, {"family": "Bustos", "given": "Natalia", "initials": "N"}, {"family": "Braeye", "given": "Toon", "initials": "T"}, {"family": "Denissov", "given": "Gleb", "initials": "G"}, {"family": "Veideman", "given": "Tatjana", "initials": "T"}, {"family": "Luomala", "given": "Oskari", "initials": "O"}, {"family": "M\u00f6tt\u00f6nen", "given": "Teemu", "initials": "T"}, {"family": "Fouillet", "given": "Anne", "initials": "A"}, {"family": "Caserio-Sch\u00f6nemann", "given": "C\u00e9line", "initials": "C"}, {"family": "An der Heiden", "given": "Matthias", "initials": "M"}, {"family": "Uphoff", "given": "Helmut", "initials": "H"}, {"family": "Lytras", "given": "Theodore", "initials": "T"}, {"family": "Gkolfinopoulou", "given": "Kassiani", "initials": "K"}, {"family": "Paldy", "given": "Anna", "initials": "A"}, {"family": "Domegan", "given": "Lisa", "initials": "L"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}, {"family": "De' Donato", "given": "Francesca", "initials": "F"}, {"family": "Noccioli", "given": "Fiammetta", "initials": "F"}, {"family": "Hoffmann", "given": "Patrick", "initials": "P"}, {"family": "Velez", "given": "Telma", "initials": "T"}, {"family": "England", "given": "Kathleen", "initials": "K"}, {"family": "van Asten", "given": "Liselotte", "initials": "L"}, {"family": "White", "given": "Richard A", "initials": "RA"}, {"family": "T\u00f8nnessen", "given": "Ragnhild", "initials": "R"}, {"family": "da Silva", "given": "Susana P", "initials": "SP"}, {"family": "Rodrigues", "given": "Ana P", "initials": "AP"}, {"family": "Larrauri", "given": "Amparo", "initials": "A"}, {"family": "Delgado-Sanz", "given": "Concepci\u00f3n", "initials": "C"}, {"family": "Farah", "given": "Ahmed", "initials": "A"}, {"family": "Galanis", "given": "Ilias", "initials": "I"}, {"family": "Junker", "given": "Christoph", "initials": "C"}, {"family": "Perisa", "given": "Damir", "initials": "D"}, {"family": "Sinnathamby", "given": "Mary", "initials": "M"}, {"family": "Andrews", "given": "Nick", "initials": "N"}, {"family": "O'Doherty", "given": "Mark", "initials": "M"}, {"family": "Marquess", "given": "Diogo Fp", "initials": "DF"}, {"family": "Kennedy", "given": "Sharon", "initials": "S"}, {"family": "Olsen", "given": "Sonja J", "initials": "SJ"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "ECDC Public Health Emergency Team for COVID-19", "given": "", "initials": ""}, {"family": "Krause", "given": "Tyra G", "initials": "TG"}, {"family": "M\u00f8lbak", "given": "K\u00e5re", "initials": "K"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "26", "issn-l": null}, "abstract": "A remarkable excess mortality has coincided with the COVID-19 pandemic in Europe. We present preliminary pooled estimates of all-cause mortality for 24 European countries/federal states participating in the European monitoring of excess mortality for public health action (EuroMOMO) network, for the period March-April 2020. Excess mortality particularly affected \u2265 65 year olds (91% of all excess deaths), but also 45-64 (8%) and 15-44 year olds (1%). No excess mortality was observed in 0-14 year olds.", "doi": "10.2807/1560-7917.ES.2020.25.26.2001214", "pmid": "32643601", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7346364"}], "notes": [], "created": "2020-12-08T14:29:31.649Z", "modified": "2020-12-08T14:29:31.659Z"}, {"entity": "publication", "iuid": "edf06ad57a0542d6a1ecd42c8c6c3cc2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/edf06ad57a0542d6a1ecd42c8c6c3cc2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/edf06ad57a0542d6a1ecd42c8c6c3cc2"}}, "title": "European Society for Neurogastroenterology and Motility recommendations for conducting gastrointestinal motility and function testing in the recovery phase of the COVID-19 pandemic.", "authors": [{"family": "Tack", "given": "Jan", "initials": "J"}, {"family": "Vanuytsel", "given": "Tim", "initials": "T"}, {"family": "Serra", "given": "Jordi", "initials": "J"}, {"family": "Accarino", "given": "Anna", "initials": "A"}, {"family": "Stanghellini", "given": "Vincenzo", "initials": "V"}, {"family": "Barbara", "given": "Giovanni", "initials": "G"}, {"family": "ESNM Consensus Group, the Leuven Consensus Group, the Italian Consensus Group, the Spanish Consensus Group on function testing in the COVID-19 pandemic era", "given": "", "initials": ""}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Neurogastroenterol Motil", "issn": "1365-2982", "volume": "32", "issue": "7", "pages": "e13930", "issn-l": null}, "abstract": "During the peak of the COronaVIrus Disease 2019 (COVID-19) pandemic, care for patients with gastrointestinal motility and functional disorders was largely suspended. In the recovery phases of the pandemic, non-urgent medical care is resumed, but there is a lack of guidance for restarting and safely conducting motility and function testing. Breath tests and insertion of manometry and pH-monitoring probes carry a risk of SARS-CoV-2 spread through droplet formation.\n\nA panel of experts from the European Society for Neurogastroenterology and Motility (ESNM) evaluated emerging national and single-center recommendations to provide the best current evidence and a pragmatic approach to ensure the safe conduct of motility and function testing for both healthcare professionals and patients.\n\nAt a general level, this involves evaluation of the urgency of the procedure, evaluation of the infectious risk associated with the patient, the investigation and the healthcare professional(s) involved, provision of the test planning and test units, education and training of staff, and use of personnel protection equipment. Additional guidance is provided for specific procedures such as esophageal manometry, pH monitoring, and breath tests.\n\nThe ESNM guidelines provide pragmatic and appropriate guidance for the safe conduct of motility and function testing in the COVID-19 pandemic and early recovery phase.", "doi": "10.1111/nmo.13930", "pmid": "32525249", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7300574"}], "notes": [], "created": "2020-12-09T10:07:33.877Z", "modified": "2020-12-09T10:07:33.899Z"}, {"entity": "publication", "iuid": "8af419f2fae34df29919e6ee13faddcc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8af419f2fae34df29919e6ee13faddcc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8af419f2fae34df29919e6ee13faddcc"}}, "title": "European Association of Urology Guidelines Office Rapid Reaction Group: An Organisation-wide Collaborative Effort to Adapt the European Association of Urology Guidelines Recommendations to the Coronavirus Disease 2019 Era.", "authors": [{"family": "Ribal", "given": "Maria J", "initials": "MJ"}, {"family": "Cornford", "given": "Philip", "initials": "P"}, {"family": "Briganti", "given": "Alberto", "initials": "A"}, {"family": "Knoll", "given": "Thomas", "initials": "T"}, {"family": "Gravas", "given": "Stavros", "initials": "S"}, {"family": "Babjuk", "given": "Marek", "initials": "M"}, {"family": "Harding", "given": "Christopher", "initials": "C"}, {"family": "Breda", "given": "Alberto", "initials": "A"}, {"family": "Bex", "given": "Axel", "initials": "A"}, {"family": "GORRG Group", "given": "", "initials": ""}, {"family": "Rassweiler", "given": "Jens J", "initials": "JJ"}, {"family": "G\u00f6zen", "given": "Ali S", "initials": "AS"}, {"family": "Pini", "given": "Giovannalberto", "initials": "G"}, {"family": "Liatsikos", "given": "Evangelos", "initials": "E"}, {"family": "Giannarini", "given": "Gianluca", "initials": "G"}, {"family": "Mottrie", "given": "Alex", "initials": "A"}, {"family": "Subramaniam", "given": "Ramnath", "initials": "R"}, {"family": "Sofikitis", "given": "Nikolaos", "initials": "N"}, {"family": "Rocco", "given": "Bernardo M C", "initials": "BMC"}, {"family": "Xie", "given": "Li-Ping", "initials": "LP"}, {"family": "Witjes", "given": "J Alfred", "initials": "JA"}, {"family": "Mottet", "given": "Nicolas", "initials": "N"}, {"family": "Ljungberg", "given": "B\u00f6rje", "initials": "B"}, {"family": "Roupr\u00eat", "given": "Morgan", "initials": "M"}, {"family": "Laguna", "given": "Maria P", "initials": "MP"}, {"family": "Salonia", "given": "Andrea", "initials": "A"}, {"family": "Bonkat", "given": "Gernot", "initials": "G"}, {"family": "Blok", "given": "Bertil F M", "initials": "BFM"}, {"family": "T\u00fcrk", "given": "Christian", "initials": "C"}, {"family": "Radmayr", "given": "Christian", "initials": "C"}, {"family": "Kitrey", "given": "Noam D", "initials": "ND"}, {"family": "Engeler", "given": "Daniel S", "initials": "DS"}, {"family": "Lumen", "given": "Nicolaas", "initials": "N"}, {"family": "Hakenberg", "given": "Oliver W", "initials": "OW"}, {"family": "Watkin", "given": "Nick", "initials": "N"}, {"family": "Hamid", "given": "Rizwan", "initials": "R"}, {"family": "Olsburgh", "given": "Jonathon", "initials": "J"}, {"family": "Darraugh", "given": "Julie", "initials": "J"}, {"family": "Shepherd", "given": "Robert", "initials": "R"}, {"family": "Smith", "given": "Emma-Jane", "initials": "EJ"}, {"family": "Chapple", "given": "Christopher R", "initials": "CR"}, {"family": "Stenzl", "given": "Arnulf", "initials": "A"}, {"family": "Van Poppel", "given": "Hendrik", "initials": "H"}, {"family": "Wirth", "given": "Manfred", "initials": "M"}, {"family": "S\u00f8nksen", "given": "Jens", "initials": "J"}, {"family": "N'Dow", "given": "James", "initials": "J"}, {"family": "EAU Section Offices and the EAU Guidelines Panels", "given": "", "initials": ""}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Eur Urol", "issn": "1873-7560", "volume": "78", "issue": "1", "pages": "21-28", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic is unlike anything seen before by modern science-based medicine. Health systems across the world are struggling to manage it. Added to this struggle are the effects of social confinement and isolation. This brings into question whether the latest guidelines are relevant in this crisis. We aim to support urologists in this difficult situation by providing tools that can facilitate decision making, and to minimise the impact and risks for both patients and health professionals delivering urological care, whenever possible. We hope that the revised recommendations will assist urologist surgeons across the globe to guide the management of urological conditions during the current COVID-19 pandemic.", "doi": "10.1016/j.eururo.2020.04.056", "pmid": "32376137", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0302-2838(20)30324-9"}, {"db": "pmc", "key": "PMC7183974"}], "notes": [], "created": "2020-12-10T07:36:06.469Z", "modified": "2020-12-10T07:36:06.491Z"}, {"entity": "publication", "iuid": "72356b6b1430403297ae0fd5a1af6e57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/72356b6b1430403297ae0fd5a1af6e57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/72356b6b1430403297ae0fd5a1af6e57"}}, "title": "Ethical triage during the COVID-19 pandemic: a toolkit for neurosurgical resource allocation.", "authors": [{"family": "Hulsbergen", "given": "Alexander F C", "initials": "AFC"}, {"family": "Eijkholt", "given": "Marleen M", "initials": "MM"}, {"family": "Balak", "given": "Naci", "initials": "N"}, {"family": "Brennum", "given": "Jannick", "initials": "J"}, {"family": "Bolger", "given": "Ciar\u00e1n", "initials": "C"}, {"family": "Bohrer", "given": "Anna-Margarete", "initials": "AM"}, {"family": "Feldman", "given": "Zeev", "initials": "Z"}, {"family": "Holsgrove", "given": "Daniel", "initials": "D"}, {"family": "Kitchen", "given": "Neil", "initials": "N"}, {"family": "Mathiesen", "given": "Tiit I", "initials": "TI"}, {"family": "Moojen", "given": "Wouter A", "initials": "WA"}, {"family": "Sampr\u00f3n", "given": "Nicol\u00e1s", "initials": "N"}, {"family": "Sames", "given": "Martin", "initials": "M"}, {"family": "Sandvik", "given": "Ulrika", "initials": "U"}, {"family": "Tisell", "given": "Magnus", "initials": "M"}, {"family": "Broekman", "given": "Marike L D", "initials": "MLD"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Acta Neurochir (Wien)", "issn": "0942-0940", "volume": "162", "issue": "7", "pages": "1485-1490", "issn-l": "0001-6268"}, "abstract": "The COVID-19 pandemic confronts healthcare workers, including neurosurgeons, with difficult choices regarding which patients to treat.\n\nIn order to assist ethical triage, this article gives an overview of the main considerations and ethical principles relevant when allocating resources in times of scarcity.\n\nWe discuss a framework employing four principles: prioritizing the worst off, maximizing benefits, treating patients equally, and promoting instrumental value. We furthermore discuss the role of age and comorbidity in triage and highlight some principles that may seem intuitive but should not form a basis for triage.\n\nThis overview is presented on behalf of the European Association of Neurosurgical Societies and can be used as a toolkit for neurosurgeons faced with ethical dilemmas when triaging patients in times of scarcity.", "doi": "10.1007/s00701-020-04375-w", "pmid": "32405671", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00701-020-04375-w"}, {"db": "pmc", "key": "PMC7220806"}], "notes": [], "created": "2020-11-25T08:04:50.218Z", "modified": "2020-11-30T09:07:55.694Z"}, {"entity": "publication", "iuid": "9b890af069da4a43983d613b4392d539", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b890af069da4a43983d613b4392d539.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b890af069da4a43983d613b4392d539"}}, "title": "Development of passive immunity against SARS-CoV-2 for management of immunodeficient patients-a perspective.", "authors": [{"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}], "type": "editorial", "published": "2020-07-00", "journal": {"title": "J Allergy Clin Immunol", "issn": "1097-6825", "issn-l": "0091-6749", "volume": "146", "issue": "1", "pages": "58-60"}, "abstract": "Editorial", "doi": "10.1016/j.jaci.2020.04.043", "pmid": "32413374", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: H2020": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0091-6749(20)30645-X"}, {"db": "pmc", "key": "PMC7215168"}], "notes": [], "created": "2020-11-25T08:26:38.332Z", "modified": "2021-02-26T08:45:48.511Z"}, {"entity": "publication", "iuid": "449b2397650449f9adffd907a41a9b9d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/449b2397650449f9adffd907a41a9b9d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/449b2397650449f9adffd907a41a9b9d"}}, "title": "COVID-19, chronic inflammatory respiratory diseases and eosinophils-Observations from reported clinical case series.", "authors": [{"family": "Jesenak", "given": "Milos", "initials": "M"}, {"family": "Banovcin", "given": "Peter", "initials": "P"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}], "type": "letter", "published": "2020-07-00", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": "75", "issue": "7", "pages": "1819-1822", "issn-l": "0105-4538"}, "abstract": null, "doi": "10.1111/all.14353", "pmid": "32369190", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-10T07:28:22.865Z", "modified": "2020-12-10T07:28:22.875Z"}, {"entity": "publication", "iuid": "8fc1af79aa724fc4bf30f7dd2e362aff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8fc1af79aa724fc4bf30f7dd2e362aff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8fc1af79aa724fc4bf30f7dd2e362aff"}}, "title": "COVID-19 in pregnancy with comorbidities: More liberal testing strategy is needed.", "authors": [{"family": "Gidl\u00f6f", "given": "Sebastian", "initials": "S"}, {"family": "Savchenko", "given": "Julia", "initials": "J"}, {"family": "Brune", "given": "Thomas", "initials": "T"}, {"family": "Josefsson", "given": "Hampus", "initials": "H"}], "type": "letter", "published": "2020-07-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "7", "pages": "948-949", "issn-l": "0001-6349"}, "abstract": null, "doi": "10.1111/aogs.13862", "pmid": "32249924", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-22T17:08:12.943Z", "modified": "2020-12-09T11:49:29.739Z"}, {"entity": "publication", "iuid": "f546322941284eb1a9ff39d0517dfcdd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f546322941284eb1a9ff39d0517dfcdd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f546322941284eb1a9ff39d0517dfcdd"}}, "title": "COVID-19 in People With Diabetes: Urgently Needed Lessons From Early Reports.", "authors": [{"family": "Riddle", "given": "Matthew C", "initials": "MC"}, {"family": "Buse", "given": "John B", "initials": "JB"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Knowler", "given": "William C", "initials": "WC"}, {"family": "Ratner", "given": "Robert E", "initials": "RE"}, {"family": "Selvin", "given": "Elizabeth", "initials": "E"}, {"family": "Wexler", "given": "Deborah J", "initials": "DJ"}, {"family": "Kahn", "given": "Steven E", "initials": "SE"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Diabetes Care", "issn": "1935-5548", "volume": "43", "issue": "7", "pages": "1378-1381", "issn-l": null}, "abstract": null, "doi": "10.2337/dci20-0024", "pmid": "32409505", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "dci20-0024"}, {"db": "pmc", "key": "PMC7305002"}], "notes": [], "created": "2020-12-10T08:50:46.407Z", "modified": "2020-12-10T08:50:46.431Z"}, {"entity": "publication", "iuid": "fb335d814dd541c58f67290f3969d67f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb335d814dd541c58f67290f3969d67f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb335d814dd541c58f67290f3969d67f"}}, "title": "COVID-19 Pandemic: Consensus guidelines for preferred practices in an aesthetic clinic.", "authors": [{"family": "Kapoor", "given": "Krishan M", "initials": "KM"}, {"family": "Chatrath", "given": "Vandana", "initials": "V"}, {"family": "Boxley", "given": "Sarah G", "initials": "SG"}, {"family": "Nurlin", "given": "Iman", "initials": "I"}, {"family": "Snozzi", "given": "Philippe", "initials": "P"}, {"family": "Demosthenous", "given": "Nestor", "initials": "N"}, {"family": "Belo", "given": "Victoria", "initials": "V"}, {"family": "Chan", "given": "Wai M", "initials": "WM"}, {"family": "Kanaris", "given": "Nicole", "initials": "N"}, {"family": "Kapoor", "given": "Puneet", "initials": "P"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Dermatol Ther", "issn": "1529-8019", "volume": "33", "issue": "4", "pages": "e13597", "issn-l": null}, "abstract": "Strict infection control measures in response to the current COVID-19 pandemic are expected to remain for an extended period. In aesthetic clinics, most procedures are provided on one to one basis by the physician or therapist. In such a scenario, guidelines detailing the infection control measures for aesthetic clinics are of particular importance. An online meeting of an international group of experts in the field of aesthetic medicine, with experience in administration of an aesthetic clinic, was convened. The meeting aimed to provide a set of consensus guidelines to protect clinic staff and patients from SARS-CoV-2 infection. Consensus guidelines for \"preferred practices\" were provided for scheduling of patients, patient evaluation and triaging, and for safety precautions about the different procedures. Procedures were categorized into low-risk, moderate risk, and high-risk based on the likelihood of transmission of SARS-CoV-2 virus from the patient to the treating physician or therapist. While not intended to be complete or exhaustive, these guidelines provide sound infection control measures for aesthetic practices. Since guidelines regarding safety measures and use of PPEs may vary from country to country, the local guidelines should also be followed to prevent COVID-19 infection in aesthetic clinics.", "doi": "10.1111/dth.13597", "pmid": "32415753", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7267045"}], "notes": [], "created": "2020-11-30T09:07:54.552Z", "modified": "2020-11-30T09:07:54.576Z"}, {"entity": "publication", "iuid": "18d87d9d720145059313eeaec0571d68", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18d87d9d720145059313eeaec0571d68.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18d87d9d720145059313eeaec0571d68"}}, "title": "Author Correction: Caring for patients with cancer in the COVID-19 era.", "authors": [{"family": "van de Haar", "given": "Joris", "initials": "J"}, {"family": "Hoes", "given": "Louisa R", "initials": "LR"}, {"family": "Coles", "given": "Charlotte E", "initials": "CE"}, {"family": "Seamon", "given": "Kenneth", "initials": "K"}, {"family": "Fr\u00f6hling", "given": "Stefan", "initials": "S"}, {"family": "J\u00e4ger", "given": "Dirk", "initials": "D"}, {"family": "Valenza", "given": "Franco", "initials": "F"}, {"family": "de Braud", "given": "Filippo", "initials": "F"}, {"family": "De Petris", "given": "Luigi", "initials": "L"}, {"family": "Bergh", "given": "Jonas", "initials": "J"}, {"family": "Ernberg", "given": "Ingemar", "initials": "I"}, {"family": "Besse", "given": "Benjamin", "initials": "B"}, {"family": "Barlesi", "given": "Fabrice", "initials": "F"}, {"family": "Garralda", "given": "Elena", "initials": "E"}, {"family": "Piris-Gim\u00e9nez", "given": "Alejandro", "initials": "A"}, {"family": "Baumann", "given": "Michael", "initials": "M"}, {"family": "Apolone", "given": "Giovanni", "initials": "G"}, {"family": "Soria", "given": "Jean Charles", "initials": "JC"}, {"family": "Tabernero", "given": "Josep", "initials": "J"}, {"family": "Caldas", "given": "Carlos", "initials": "C"}, {"family": "Voest", "given": "Emile E", "initials": "EE"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "volume": "26", "issue": "7", "pages": "1146", "issn-l": "1078-8956"}, "abstract": "An amendment to this paper has been published and can be accessed via a link at the top of the paper.", "doi": "10.1038/s41591-020-0948-7", "pmid": "32494062", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-020-0948-7"}, {"db": "pmc", "key": "PMC7269160"}], "notes": [], "created": "2020-11-25T09:38:02.969Z", "modified": "2020-12-09T10:49:33.755Z"}, {"entity": "publication", "iuid": "34041685e841481e8a7c442c69f3fa9d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/34041685e841481e8a7c442c69f3fa9d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/34041685e841481e8a7c442c69f3fa9d"}}, "title": "Addendum for Euro Surveill. 2020;25(3).", "authors": [{"family": "Eurosurveillance editorial team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "25", "issue": "30", "pages": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.30.2007302", "pmid": "32734858", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7393855"}], "notes": [], "created": "2020-12-07T16:06:30.575Z", "modified": "2020-12-11T12:57:17.295Z"}, {"entity": "publication", "iuid": "5773f521dcfb40b5a8b8f3f58606e0fb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5773f521dcfb40b5a8b8f3f58606e0fb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5773f521dcfb40b5a8b8f3f58606e0fb"}}, "title": "A survey on the impact of the COVID-19 pandemic on motility and functional investigations in Europe and considerations for recommencing activities in the early recovery phase.", "authors": [{"family": "Tack", "given": "Jan", "initials": "J"}, {"family": "Schol", "given": "Jolien", "initials": "J"}, {"family": "Geeraerts", "given": "Annelies", "initials": "A"}, {"family": "Huang", "given": "I-Hsuan", "initials": "I"}, {"family": "Mori", "given": "Hideki", "initials": "H"}, {"family": "Scarpellini", "given": "Emidio", "initials": "E"}, {"family": "Sinonquel", "given": "Pieter", "initials": "P"}, {"family": "Carbone", "given": "Florencia", "initials": "F"}, {"family": "Colomier", "given": "Esther", "initials": "E"}, {"family": "Geysen", "given": "Hannelore", "initials": "H"}, {"family": "Jandee", "given": "Sawangpong", "initials": "S"}, {"family": "Moonen", "given": "An", "initials": "A"}, {"family": "Pannemans", "given": "Jasper", "initials": "J"}, {"family": "Timmermans", "given": "Lien", "initials": "L"}, {"family": "Van den Houte", "given": "Karen", "initials": "K"}, {"family": "Verbeure", "given": "Wout", "initials": "W"}, {"family": "Wauters", "given": "Lucas", "initials": "L"}, {"family": "Bisschops", "given": "Raf", "initials": "R"}, {"family": "Hoffman", "given": "Ilse", "initials": "I"}, {"family": "Roelandt", "given": "Philip", "initials": "P"}, {"family": "Rommel", "given": "Nathalie", "initials": "N"}, {"family": "Simren", "given": "Magnus", "initials": "M"}, {"family": "Suzuki", "given": "Hidekazu", "initials": "H"}, {"family": "Tornblom", "given": "Hans", "initials": "H"}, {"family": "Verbeke", "given": "Kristin", "initials": "K"}, {"family": "Vanuytsel", "given": "Tim", "initials": "T"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Neurogastroenterol Motil", "issn": "1365-2982", "issn-l": null, "volume": "32", "issue": "7", "pages": "e13926"}, "abstract": "The COVID-19 pandemic, declared by WHO on March 13, 2020, had a major global impact on the healthcare system and services. In the acute phase, the presence of the SARS-CoV-2 virus in the aerodigestive tract limited activities in the gastroenterology clinic and procedures to emergencies only. Motility and function testing was interrupted and as we enter the recovery phase, restarting these procedures requires a safety-focused approach with adequate infection prevention for patients and healthcare professionals.\r\n\r\nWe summarized knowledge on the presence of the SARS-CoV-2 virus in the aerodigestive tract and the risk of spread with motility and functional testing. We surveyed 39 European centers documenting how the pandemic affected activities and which measures they are considering for restarting these measurements. We propose recommendations based on current knowledge as applied in our center.\r\n\r\nPositioning of catheters for gastrointestinal motility tests carries a concern for aerosol-borne infection of healthcare workers. The risk is low with breath tests. The surveyed centers stopped almost all motility and function tests from the second half of March. The speed of restarting and the safety measures taken varied highly.\r\n\r\nBased on these findings, we provided recommendations and practical relevant information for motility and function test procedures in the COVID-19 pandemic era, to guarantee a high-quality patient care with adequate infection prevention.", "doi": "10.1111/nmo.13926", "pmid": "32478910", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7300498"}], "notes": [], "created": "2020-12-09T10:55:29.360Z", "modified": "2022-11-10T07:48:14.803Z"}, {"entity": "publication", "iuid": "c508cdc6f84d4fdb8086e170d12eb911", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c508cdc6f84d4fdb8086e170d12eb911.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c508cdc6f84d4fdb8086e170d12eb911"}}, "title": "Safe performance of echocardiography during the COVID-19 pandemic: a practical guide.", "authors": [{"family": "Cameli", "given": "Matteo", "initials": "M"}, {"family": "Pastore", "given": "Maria Concetta", "initials": "MC"}, {"family": "Henein", "given": "Michael", "initials": "M"}, {"family": "Aboumarie", "given": "Hatem Soliman", "initials": "HS"}, {"family": "Mandoli", "given": "Giulia Elena", "initials": "GE"}, {"family": "D'Ascenzi", "given": "Flavio", "initials": "F"}, {"family": "Cameli", "given": "Paolo", "initials": "P"}, {"family": "Franchi", "given": "Federico", "initials": "F"}, {"family": "Mondillo", "given": "Sergio", "initials": "S"}, {"family": "Valente", "given": "Serafina", "initials": "S"}], "type": "journal article", "published": "2020-06-30", "journal": {"title": "Rev Cardiovasc Med", "issn": "1530-6550", "volume": "21", "issue": "2", "pages": "217-223", "issn-l": null}, "abstract": "Coronavirus disease-2019 (COVID-19) outbreak has become a worldwide healthcare emergency, with continuously growing number of infected subjects. Considering the easy virus spread through respiratory droplets produced with cough, sneezes or spit or through close contact with infected people or surfaces, healthcare workers are further exposed to COVID-19. Particularly, echocardiography remains an essential diagnostic service which, due to the close contact with patients during the exam, provides echocardiographers high-risk of contagion. Therefore, the common modalities of performing echocardiography should be improved in this scenario, avoiding performing unnecessary exams, using the appropriate personal protective equipment depending on patients' status and location, optimizing time-effectiveness of the echocardiographic study and accurately sanitizing the environment and devices after each exam. This paper aims to provide a simple guide for the clinicians to balance between providing the best care to each patient and protecting themselves and other patients from the spread of the virus. It also proposes the use of the mnemonic PREVENT to resume the crucial indications to be followed for the execution of appropriate echocardiographic examination during the COVID-19 pandemic.", "doi": "10.31083/j.rcm.2020.02.90", "pmid": "32706210", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "1593391605440-950946668"}], "notes": [], "created": "2020-12-07T16:19:38.826Z", "modified": "2020-12-07T16:19:38.852Z"}, {"entity": "publication", "iuid": "c5eeaacb7f194c1090380a80045ce4da", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5eeaacb7f194c1090380a80045ce4da.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5eeaacb7f194c1090380a80045ce4da"}}, "title": "Olfactory and Gustatory Outcomes in COVID-19: A Prospective Evaluation in Nonhospitalized Subjects.", "authors": [{"family": "Paderno", "given": "Alberto", "initials": "A"}, {"family": "Mattavelli", "given": "Davide", "initials": "D"}, {"family": "Rampinelli", "given": "Vittorio", "initials": "V"}, {"family": "Grammatica", "given": "Alberto", "initials": "A"}, {"family": "Raffetti", "given": "Elena", "initials": "E"}, {"family": "Tomasoni", "given": "Michele", "initials": "M"}, {"family": "Gualtieri", "given": "Tommaso", "initials": "T"}, {"family": "Taboni", "given": "Stefano", "initials": "S"}, {"family": "Zorzi", "given": "Silvia", "initials": "S"}, {"family": "Del Bon", "given": "Francesca", "initials": "F"}, {"family": "Lombardi", "given": "Davide", "initials": "D"}, {"family": "Deganello", "given": "Alberto", "initials": "A"}, {"family": "Redaelli De Zinis", "given": "Luca Oscar", "initials": "LO"}, {"family": "Schreiber", "given": "Alberto", "initials": "A"}], "type": "journal article", "published": "2020-06-30", "journal": {"title": "Otolaryngol Head Neck Surg", "issn": "1097-6817", "volume": "163", "issue": "6", "pages": "194599820939538", "issn-l": "0194-5998"}, "abstract": "To prospectively assess the rate and timing of recovery of olfactory (OD) and gustatory (GD) dysfunction in patients affected by COVID-19.\n\nCohort study.\n\nPopulation-based evaluation in a COVID-19 high-prevalence region.\n\nWe analyzed the clinical course of OD and GD in a cohort of home-quarantined SARS-CoV-2-positive patients from Northern Italy. Physicians administered a survey-based questionnaire at recruitment (T0). During follow-up, patients responded to online dedicated surveys modulated according to symptoms at T0.\n\nA total of 151 patients completed the follow-up survey. OD and/or GD were observed in 83% and 89% of subjects, respectively. Resolution rates of OD and GD at 30 days from onset were 87% and 82%, respectively. Risk factors for late resolution were grade of dysfunction at onset (total vs partial), gender, and presence of nasal congestion. Three (2%) patients previously reporting complete resolution of symptoms complained of subsequent recurrence of OD and/or GD after a mean of 19 days from resolution of the previous episode.\n\nCOVID-19-related OD and GD had high rate of resolution in the first month from onset of symptoms. However, in 10% to 15% of patients, these symptoms showed only partial improvement after this period.", "doi": "10.1177/0194599820939538", "pmid": "32600175", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7331108"}], "notes": [], "created": "2020-11-18T17:12:18.855Z", "modified": "2021-02-26T08:46:13.493Z"}, {"entity": "publication", "iuid": "d5ef2291db25489db53be5bf008166de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5ef2291db25489db53be5bf008166de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5ef2291db25489db53be5bf008166de"}}, "title": "The cholinergic anti-inflammatory pathway alleviates acute lung injury.", "authors": [{"family": "Andersson", "given": "Ulf", "initials": "U"}], "type": "letter", "published": "2020-06-29", "journal": {"title": "Mol Med", "issn": "1528-3658", "volume": "26", "issue": "1", "pages": "64", "issn-l": "1076-1551"}, "abstract": "The ubiquiotous nuclear protein HMGB1 is extracellularly released by dying cells or activated innate immunity cells to promote inflammation. Extracellular HMGB1 plays a prominent role in the pathogenesis of acute lung injury of infectious as well as sterile origin including hyperoxia. Excessive amounts of systemic HMGB1 and HMGB1-partner molecule complexes can be retained in the pulmonary circulation indicated by a substantial reduction of HMGB1 plasma levels in arterial versus venous blood. The cholinergic antiinflammatory mechanism ameliorates pulmonary inflammation by inhibiting HMGB1 release and HMGB1 receptor expression. This comprehension was recently reinforced by results reported in Molecular Medicine by Sitapara and coworkers demonstrating that administration of an \u03b17 nicotinic acetylcholine receptor agonist attenuated hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation. Activating the cholinergic antiinflammatory path might be considered to alleviate severe COVID-19 with or without concurrent oxygen-induced lung injury.", "doi": "10.1186/s10020-020-00184-0", "pmid": "32600316", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s10020-020-00184-0"}, {"db": "pmc", "key": "PMC7322708"}], "notes": [], "created": "2020-12-08T15:25:40.235Z", "modified": "2020-12-08T15:25:40.247Z"}, {"entity": "publication", "iuid": "0274d5946ea445bd80c6f37ead8dfe5e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0274d5946ea445bd80c6f37ead8dfe5e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0274d5946ea445bd80c6f37ead8dfe5e"}}, "title": "Coronavirus Disease Pandemic (COVID-19): Challenges and a Global Perspective.", "authors": [{"family": "Malik", "given": "Yashpal Singh", "initials": "YS"}, {"family": "Kumar", "given": "Naveen", "initials": "N"}, {"family": "Sircar", "given": "Shubhankar", "initials": "S"}, {"family": "Kaushik", "given": "Rahul", "initials": "R"}, {"family": "Bhat", "given": "Sudipta", "initials": "S"}, {"family": "Dhama", "given": "Kuldeep", "initials": "K"}, {"family": "Gupta", "given": "Parakriti", "initials": "P"}, {"family": "Goyal", "given": "Kapil", "initials": "K"}, {"family": "Singh", "given": "Mini P", "initials": "MP"}, {"family": "Ghoshal", "given": "Ujjala", "initials": "U"}, {"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME"}, {"family": "O R", "given": "VinodhKumar", "initials": "V"}, {"family": "Yatoo", "given": "Mohd Iqbal", "initials": "MI"}, {"family": "Tiwari", "given": "Ruchi", "initials": "R"}, {"family": "Pathak", "given": "Mamta", "initials": "M"}, {"family": "Patel", "given": "Shailesh Kumar", "initials": "SK"}, {"family": "Sah", "given": "Ranjit", "initials": "R"}, {"family": "Rodriguez-Morales", "given": "Alfonso J", "initials": "AJ"}, {"family": "Ganesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Kumar", "given": "Prashant", "initials": "P"}, {"family": "Singh", "given": "Raj Kumar", "initials": "RK"}], "type": "journal article", "published": "2020-06-28", "journal": {"title": "Pathogens", "issn": "2076-0817", "volume": "9", "issue": "7", "issn-l": "2076-0817"}, "abstract": "The technology-driven world of the 21 st century is currently confronted with a major threat to humankind, represented by the coronavirus disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome, coronavirus-2 (SARS-CoV-2). As of now, COVID-19 has affected more than 6 million confirmed cases and took 0.39 million human lives. SARS-CoV-2 spreads much faster than its two ancestors, SARS-CoV and Middle East respiratory syndrome-CoV (MERS-CoV), but has low fatality rates. Our analyses speculate that the efficient replication and transmission of SARS-CoV-2 might be due to the high-density basic amino acid residues, preferably positioned in close proximity at both the furin-like cleavage sites (S1/S2 and S2') within the spike protein. Given the high genomic similarities of SARS-CoV-2 to bat SARS-like CoVs, it is likely that bats serve as a reservoir host for its progenitor. Women and children are less susceptible to SARS-CoV-2 infection, while the elderly and people with comorbidities are more prone to serious clinical outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. The cohesive approach amongst researchers across the globe has delivered high-end viral diagnostics. However, home-based point-of-care diagnostics are still under development, which may prove transformative in current COVID-19 pandemic containment. Similarly, vaccines and therapeutics against COVID-19 are currently in the pipeline for clinical trials. In this review, we discuss the noteworthy advancements, focusing on the etiological viral agent, comparative genomic analysis, population susceptibility, disease epidemiology and diagnosis, animal reservoirs, laboratory animal models, disease transmission, therapeutics, vaccine challenges, and disease mitigation measures.", "doi": "10.3390/pathogens9070519", "pmid": "32605194", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "pathogens9070519"}, {"db": "pmc", "key": "PMC7400054"}], "notes": [], "created": "2020-11-19T14:23:51.630Z", "modified": "2020-11-30T08:54:51.546Z"}, {"entity": "publication", "iuid": "e0c42706c478434a9a7dbbba2bba0fc5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e0c42706c478434a9a7dbbba2bba0fc5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e0c42706c478434a9a7dbbba2bba0fc5"}}, "title": "Overcoming fragmentation of health research in Europe: lessons from COVID-19.", "authors": [{"family": "Sipido", "given": "Karin R", "initials": "KR"}, {"family": "Anto\u00f1anzas", "given": "Fernando", "initials": "F"}, {"family": "Celis", "given": "Julio", "initials": "J"}, {"family": "Degos", "given": "Laurent", "initials": "L"}, {"family": "Frackowiak", "given": "Richard", "initials": "R"}, {"family": "Fuster", "given": "Valentin", "initials": "V"}, {"family": "Ganten", "given": "Detlev", "initials": "D"}, {"family": "Gay", "given": "Steffen", "initials": "S"}, {"family": "Hofstraat", "given": "Hans", "initials": "H"}, {"family": "Holgate", "given": "Stephen T", "initials": "ST"}, {"family": "Krestin", "given": "Gabriel", "initials": "G"}, {"family": "Manns", "given": "Michael", "initials": "M"}, {"family": "Meunier", "given": "Francoise", "initials": "F"}, {"family": "Oertel", "given": "Wolfgang", "initials": "W"}, {"family": "Palkonen", "given": "Susanna", "initials": "S"}, {"family": "Pavalkis", "given": "Dainius", "initials": "D"}, {"family": "R\u00fcbsamen-Schaeff", "given": "Helga", "initials": "H"}, {"family": "Smith", "given": "Ulf", "initials": "U"}, {"family": "Stallknecht", "given": "Bente Merete", "initials": "BM"}, {"family": "Zima", "given": "Tom\u00e1\u0161", "initials": "T"}], "type": "letter", "published": "2020-06-27", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "395", "issue": "10242", "pages": "1970-1971", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)31411-2", "pmid": "32559417", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31411-2"}], "notes": [], "created": "2020-12-09T07:45:28.016Z", "modified": "2020-12-09T07:45:28.029Z"}, {"entity": "publication", "iuid": "72abfafc02044690936b841354712977", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/72abfafc02044690936b841354712977.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/72abfafc02044690936b841354712977"}}, "title": "Gendered effects of school closures during the COVID-19 pandemic.", "authors": [{"family": "Burzynska", "given": "Katarzyna", "initials": "K"}, {"family": "Contreras", "given": "Gabriela", "initials": "G"}], "type": "letter", "published": "2020-06-27", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "395", "issue": "10242", "pages": "1968", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)31377-5", "pmid": "32539938", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31377-5"}, {"db": "pmc", "key": "PMC7292576"}], "notes": [], "created": "2020-12-09T07:56:28.304Z", "modified": "2020-12-09T07:56:28.314Z"}, {"entity": "publication", "iuid": "2850cf94d5cb4ab8b9a654e4694fcd05", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2850cf94d5cb4ab8b9a654e4694fcd05.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2850cf94d5cb4ab8b9a654e4694fcd05"}}, "title": "Health equity and COVID-19: global perspectives.", "authors": [{"family": "Shadmi", "given": "Efrat", "initials": "E"}, {"family": "Chen", "given": "Yingyao", "initials": "Y"}, {"family": "Dourado", "given": "In\u00eas", "initials": "I"}, {"family": "Faran-Perach", "given": "Inbal", "initials": "I"}, {"family": "Furler", "given": "John", "initials": "J"}, {"family": "Hangoma", "given": "Peter", "initials": "P"}, {"family": "Hanvoravongchai", "given": "Piya", "initials": "P"}, {"family": "Obando", "given": "Claudia", "initials": "C"}, {"family": "Petrosyan", "given": "Varduhi", "initials": "V"}, {"family": "Rao", "given": "Krishna D", "initials": "KD"}, {"family": "Ruano", "given": "Ana Lorena", "initials": "AL"}, {"family": "Shi", "given": "Leiyu", "initials": "L"}, {"family": "de Souza", "given": "Luis Eugenio", "initials": "LE"}, {"family": "Spitzer-Shohat", "given": "Sivan", "initials": "S"}, {"family": "Sturgiss", "given": "Elizabeth", "initials": "E"}, {"family": "Suphanchaimat", "given": "Rapeepong", "initials": "R"}, {"family": "Uribe", "given": "Manuela Villar", "initials": "MV"}, {"family": "Willems", "given": "Sara", "initials": "S"}], "type": "letter", "published": "2020-06-26", "journal": {"title": "Int J Equity Health", "issn": "1475-9276", "volume": "19", "issue": "1", "pages": "104", "issn-l": null}, "abstract": "The COVID-19 is disproportionally affecting the poor, minorities and a broad range of vulnerable populations, due to its inequitable spread in areas of dense population and limited mitigation capacity due to high prevalence of chronic conditions or poor access to high quality public health and medical care. Moreover, the collateral effects of the pandemic due to the global economic downturn, and social isolation and movement restriction measures, are unequally affecting those in the lowest power strata of societies. To address the challenges to health equity and describe some of the approaches taken by governments and local organizations, we have compiled 13 country case studies from various regions around the world: China, Brazil, Thailand, Sub Saharan Africa, Nicaragua, Armenia, India, Guatemala, United States of America (USA), Israel, Australia, Colombia, and Belgium. This compilation is by no-means representative or all inclusive, and we encourage researchers to continue advancing global knowledge on COVID-19 health equity related issues, through rigorous research and generation of a strong evidence base of new empirical studies in this field.", "doi": "10.1186/s12939-020-01218-z", "pmid": "32586388", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12939-020-01218-z"}, {"db": "pmc", "key": "PMC7316580"}], "notes": [], "created": "2020-12-08T15:49:56.457Z", "modified": "2020-12-08T15:49:56.479Z"}, {"entity": "publication", "iuid": "721dbc34e48a45b0a8d08caa5f332526", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/721dbc34e48a45b0a8d08caa5f332526.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/721dbc34e48a45b0a8d08caa5f332526"}}, "title": "Are official confirmed cases and fatalities counts good enough to study the COVID-19 pandemic dynamics? A critical assessment through the case of Italy.", "authors": [{"family": "Bartoszek", "given": "Krzysztof", "initials": "K"}, {"family": "Guidotti", "given": "Emanuele", "initials": "E"}, {"family": "Iacus", "given": "Stefano Maria", "initials": "SM"}, {"family": "Okr\u00f3j", "given": "Marcin", "initials": "M"}], "type": "journal article", "published": "2020-06-26", "journal": {"title": "Nonlinear Dyn", "issn": "0924-090X", "volume": null, "issue": null, "pages": "1-29", "issn-l": null}, "abstract": "As the COVID-19 outbreak is developing the two most frequently reported statistics seem to be the raw confirmed case and case fatalities counts. Focusing on Italy, one of the hardest hit countries, we look at how these two values could be put in perspective to reflect the dynamics of the virus spread. In particular, we find that merely considering the confirmed case counts would be very misleading. The number of daily tests grows, while the daily fraction of confirmed cases to total tests has a change point. It (depending on region) generally increases with strong fluctuations till (around, depending on region) 15-22 March and then decreases linearly after. Combined with the increasing trend of daily performed tests, the raw confirmed case counts are not representative of the situation and are confounded with the sampling effort. This we observe when regressing on time the logged fraction of positive tests and for comparison the logged raw confirmed count. Hence, calibrating model parameters for this virus's dynamics should not be done based only on confirmed case counts (without rescaling by the number of tests), but take also fatalities and hospitalization count under consideration as variables not prone to be distorted by testing efforts. Furthermore, reporting statistics on the national level does not say much about the dynamics of the disease, which are taking place at the regional level. These findings are based on the official data of total death counts up to 15 April 2020 released by ISTAT and up to 10 May 2020 for the number of cases. In this work, we do not fit models but we rather investigate whether this task is possible at all. This work also informs about a new tool to collect and harmonize official statistics coming from different sources in the form of a package for the R statistical environment and presents the \"COVID-19 Data Hub.\"", "doi": "10.1007/s11071-020-05761-w", "pmid": "32836808", "labels": {"Type: Other": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "5761"}, {"db": "pmc", "key": "PMC7319224"}], "notes": [], "created": "2020-12-07T10:39:54.736Z", "modified": "2021-02-26T08:46:13.245Z"}, {"entity": "publication", "iuid": "9311ddb1127943c3925f38dd3fc1584b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9311ddb1127943c3925f38dd3fc1584b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9311ddb1127943c3925f38dd3fc1584b"}}, "title": "SARS-COV-2 and biomimetics: What saves the planet will save our health.", "authors": [{"family": "Stenvinkel", "given": "P", "initials": "P"}, {"family": "Painer", "given": "J", "initials": "J"}, {"family": "Shiels", "given": "P G", "initials": "PG"}, {"family": "Bansal", "given": "A", "initials": "A"}, {"family": "Fereidouni", "given": "S", "initials": "S"}, {"family": "Natterson-Horowitz", "given": "B", "initials": "B"}, {"family": "Johnson", "given": "R J", "initials": "RJ"}, {"family": "Miranda", "given": "J J", "initials": "JJ"}], "type": "journal article", "published": "2020-06-24", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1111/joim.13128", "pmid": "32583447", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7361468"}], "notes": [], "created": "2020-12-08T15:53:33.978Z", "modified": "2020-12-08T15:53:33.989Z"}, {"entity": "publication", "iuid": "abda8a50c38944a1a031a24d005c13cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abda8a50c38944a1a031a24d005c13cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abda8a50c38944a1a031a24d005c13cc"}}, "title": "Modeling quarantine during epidemics and mass-testing using drones.", "authors": [{"family": "Sedov", "given": "Leonid", "initials": "L"}, {"family": "Krasnochub", "given": "Alexander", "initials": "A"}, {"family": "Polishchuk", "given": "Valentin", "initials": "V"}], "type": "journal article", "published": "2020-06-24", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "15", "issue": "6", "pages": "e0235307", "issn-l": "1932-6203"}, "abstract": "We extend the classical SIR epidemic spread model by introducing the \"quarantined\" compartment. We solve (numerically) the differential equations that govern the extended model and quantify how quarantining \"flattens the curve\" for the proportion of infected population over time. Furthermore, we explore the potential of using drones to deliver tests, enabling mass-testing for the infection; we give a method to estimate the drone fleet needed to deliver the tests in a metropolitan area. Application of our models to COVID-19 spread in Sweden shows how the proposed methods could substantially decrease the peak number of infected people, almost without increasing the duration of the epidemic.", "doi": "10.1371/journal.pone.0235307", "pmid": "32579590", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-11647"}, {"db": "pmc", "key": "PMC7314055"}], "notes": [], "created": "2020-12-08T15:54:48.116Z", "modified": "2020-12-08T15:54:48.127Z"}, {"entity": "publication", "iuid": "eb49878592064e0ab759503cd2c0537d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb49878592064e0ab759503cd2c0537d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb49878592064e0ab759503cd2c0537d"}}, "title": "Simulation-based skills training in non-performing orthopedic surgeons: skills acquisition, motivation, and flow during the COVID-19 pandemic.", "authors": [{"family": "Hedman", "given": "Leif Rune", "initials": "LR"}, {"family": "Fell\u00e4nder-Tsai", "given": "Li", "initials": "L"}], "type": "journal article", "published": "2020-06-23", "journal": {"title": "Acta Orthop", "issn": "1745-3682", "volume": null, "issue": null, "pages": "1-5", "issn-l": null}, "abstract": null, "doi": "10.1080/17453674.2020.1781413", "pmid": "32573303", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-08T16:24:35.275Z", "modified": "2020-12-08T16:24:35.296Z"}, {"entity": "publication", "iuid": "9dfda2d805a9485fa5c8459fbd46db7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9dfda2d805a9485fa5c8459fbd46db7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9dfda2d805a9485fa5c8459fbd46db7a"}}, "title": "Re-positive Cases of Nucleic Acid Tests in Discharged Patients With COVID-19: A Follow-Up Study.", "authors": [{"family": "Qiao", "given": "Xi-Min", "initials": "XM"}, {"family": "Xu", "given": "Xiao-Feng", "initials": "XF"}, {"family": "Zi", "given": "Hao", "initials": "H"}, {"family": "Liu", "given": "Guo-Xiong", "initials": "GX"}, {"family": "Li", "given": "Bing-Hui", "initials": "BH"}, {"family": "Du", "given": "Xiang", "initials": "X"}, {"family": "Tian", "given": "Zhi-Hai", "initials": "ZH"}, {"family": "Liu", "given": "Xiao-Ying", "initials": "XY"}, {"family": "Luo", "given": "Li-Sha", "initials": "LS"}, {"family": "Wang", "given": "Xiao", "initials": "X"}], "type": "journal article", "published": "2020-06-23", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "7", "issue": null, "pages": "349", "issn-l": null}, "abstract": "Background: The frequent emergence of the re-positive patients with COVID-19 is a potential threat worldwide. This study aimed to describe data from admission to follow-up for patients with COVID-19 and analyze the possible causes for re-positive nucleic acid tests to provide more scientific basis for reducing the numbers of re-positive patients after discharge. Methods: We retrospectively recorded 15 patients with COVID-19 admitted to the Xianyang Central Hospital, China. The baseline, exposure histories, clinical syndromes, laboratory characteristics, nucleic acid, and follow-up tests were analyzed, and the radiological characteristics of re-positive patient at different periods were compared. Results: Eight (53.33%) patients had the history of travel to Wuhan, four (26.67%) patients had close contact with confirmed patients, and one (6.67%) patient had close contact with suspected patients. After treatment, all patients had two consecutively negative nucleic acid tests and were discharged from hospital. All patients were followed up for more than 14 days, and the average time from discharge to the first follow-up was 14.67 \u00b1 3.31 days (from 9 to 22 days). Most patients showed no clinical symptoms and negative nucleic acid tests, while one patient had an itchy throat, her CT scan showed a light density shadow in the right lower lobe of the lung, and the nucleic acid was once again positive. The second follow-up of the other 14 patients (except the re-positive one) was conducted 20.80 \u00b1 7.78 days (from 13 to 30 days) after discharge, and all of them had negative nucleic acid tests. The positive patient was immediately readmitted and received a new round of treatment. Her family members and colleagues remained healthy until now. Conclusions: The quality of nucleic acid testing reagents should be enhanced, and the training of nucleic acid sampling operators should be strengthened to reduce the false-negative results in the nucleic acid of SARS-CoV-2; the clinical specimens of throat and nasopharynx swabs can be collected at the same time; IgM- and IgG-specific antibodies of SARS-CoV-2 should be carried out for discharged patients; the radiological characteristics should be evaluated strictly; and the discharge standard can be specified according to the baseline and severity of disease of patients.", "doi": "10.3389/fmed.2020.00349", "pmid": "32656223", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "All data provided in the article", "description": null}], "notes": [], "created": "2020-12-08T14:14:57.177Z", "modified": "2021-02-26T08:45:48.527Z"}, {"entity": "publication", "iuid": "9428858ffe57443e8565e9bc0c31a4de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9428858ffe57443e8565e9bc0c31a4de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9428858ffe57443e8565e9bc0c31a4de"}}, "title": "Maximizing Safety in the Conduct of Alzheimer's Disease Fluid Biomarker Research in the Era of COVID-19.", "authors": [{"family": "Schindler", "given": "Suzanne E", "initials": "SE"}, {"family": "Jicha", "given": "Gregory A", "initials": "GA"}, {"family": "Nelson", "given": "Peter T", "initials": "PT"}, {"family": "Keene", "given": "C Dirk", "initials": "CD"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Molinuevo", "given": "Jos\u00e9 Luis", "initials": "JL"}, {"family": "Masters", "given": "Colin L", "initials": "CL"}, {"family": "Hansson", "given": "Oskar", "initials": "O"}, {"family": "Teunissen", "given": "Charlotte E", "initials": "CE"}, {"family": "Galasko", "given": "Douglas", "initials": "D"}, {"family": "Shaw", "given": "Leslie M", "initials": "LM"}, {"family": "Levey", "given": "Allan I", "initials": "AI"}, {"family": "Silverberg", "given": "Nina", "initials": "N"}], "type": "letter", "published": "2020-06-23", "journal": {"title": "J Alzheimers Dis", "issn": "1875-8908", "volume": "76", "issue": "1", "pages": "27-31", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic led to an abrupt halt of many Alzheimer's disease (AD) research studies at sites spanning the world. This is especially true for studies requiring in-person contact, such as studies collecting biofluids. Since COVID-19 is likely to remain a threat for an extended period, the resumption of fluid biomarker studies requires the development and implementation of procedures that minimize the risk of in-person visits to participants, staff, and individuals handling the biofluid samples. Some issues to consider include structuring the visit workflow to minimize contacts and promote social distancing; screening and/or testing participants and staff for COVID-19; wearing masks and performing hand hygiene; and precautions for handling, storing, and analyzing biofluids. AD fluid biomarker research remains a vitally important public health priority and resuming studies requires appropriate safety procedures to protect research participants and staff.", "doi": "10.3233/JAD-200684", "pmid": "32568212", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "JAD200684"}], "notes": [], "created": "2020-12-08T16:29:25.802Z", "modified": "2020-12-08T16:29:25.825Z"}, {"entity": "publication", "iuid": "26a3f95ac88b41c4a35b29165a82f0e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26a3f95ac88b41c4a35b29165a82f0e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26a3f95ac88b41c4a35b29165a82f0e7"}}, "title": "Does a surgical helmet provide protection against aerosol transmitted disease?", "authors": [{"family": "Temmesfeld", "given": "Max Joachim", "initials": "MJ"}, {"family": "Jakobsen", "given": "Rune Bruhn", "initials": "RB"}, {"family": "Grant", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2020-06-23", "journal": {"title": "Acta Orthop", "issn": "1745-3682", "volume": null, "issue": null, "pages": "1-5", "issn-l": null}, "abstract": "Background and purpose - The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to a global shortage of personal protective equipment (PPE). Various alternatives to ordinary PPE have been suggested to reduce transmission, which is primarily through droplets and aerosols. For many years orthopedic surgeons have been using surgical helmets as personal protection against blood-borne pathogens during arthroplasty surgery. We have investigated the possibility of using the Stryker Flyte surgical helmet as a respiratory protective device against airborne- and droplet-transmitted disease, since the helmet shares many features with powered air-purifying respirators.Materials and methods - Using an aerosol particle generator, we determined the filtration capacity of the Stryker Flyte helmet by placing particle counters measuring the concentrations of 0.3, 0.5, and 5 \u00b5m particles inside and outside of the helmet.Results - We found that the helmet has insufficient capacity for filtrating aerosol particles, and, for 0.3 \u00b5m sized particles, we even recorded an accumulation of particles inside the helmet.Interpretation - We conclude that the Stryker Flyte surgical helmet should not be used as a respiratory protective device when there is a risk for exposure to aerosol containing SARS-CoV-2, the virus causing COVID-19, in accordance with the recommendation from the manufacturer.", "doi": "10.1080/17453674.2020.1771525", "pmid": "32573285", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-08T16:25:11.699Z", "modified": "2020-12-08T16:25:11.711Z"}, {"entity": "publication", "iuid": "2370821b31b14cf8a22f331c2d6bbe77", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2370821b31b14cf8a22f331c2d6bbe77.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2370821b31b14cf8a22f331c2d6bbe77"}}, "title": "COVID-19 IDD: A global survey exploring the impact of COVID-19 on individuals with intellectual and developmental disabilities and their caregivers.", "authors": [{"family": "Linehan", "given": "Christine", "initials": "C"}, {"family": "Araten-Bergam", "given": "Tal", "initials": "T"}, {"family": "Beadle-Brown", "given": "Julie", "initials": "J"}, {"family": "Bigby", "given": "Christine", "initials": "C"}, {"family": "Birkbeck", "given": "Gail", "initials": "G"}, {"family": "Bradley", "given": "Valerie", "initials": "V"}, {"family": "Brown", "given": "Michael", "initials": "M"}, {"family": "Bredewold", "given": "Femmianne", "initials": "F"}, {"family": "Chirwa", "given": "Masauso", "initials": "M"}, {"family": "Kanova", "given": "Sarka", "initials": "S"}, {"family": "Kroll", "given": "Thilo", "initials": "T"}, {"family": "MacLachlan", "given": "Mac", "initials": "M"}, {"family": "Narayan", "given": "Jayanthi", "initials": "J"}, {"family": "Nearchou", "given": "Finiki", "initials": "F"}, {"family": "Nolan", "given": "Adam", "initials": "A"}, {"family": "O'Donovan", "given": "Mary-Ann", "initials": "MA"}, {"family": "Santos", "given": "Flavia H", "initials": "FH"}, {"family": "Siska", "given": "Jan", "initials": "J"}, {"family": "Tideman", "given": "Magnus", "initials": "M"}, {"family": "Tossebro", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2020-06-23", "journal": {"title": "HRB Open Res", "issn": "2515-4826", "volume": "3", "issue": null, "pages": "39", "issn-l": null}, "abstract": "Background: This protocol outlines research to explore the impact of coronavirus disease 2019 (COVID-19) on individuals who have intellectual and developmental disabilities and their caregivers. Evidence suggests that people with intellectual and developmental disabilities experience disparities in healthcare access and utilisation. This disparity was evident early in the pandemic when discussions arose regarding the potential exclusion of this population to critical care. Methods: An anonymous online survey will be conducted with caregivers, both family members and paid staff, to explore the impact of COVID-19 on this population in terms of demographics, living arrangements, access to services, the impact of social distancing, and also carer wellbeing. The survey will be developed by the research team, many of whom are experts in intellectual disability within their own jurisdictions. Using back-translation our team will translate the survey for distribution in 16 countries worldwide for international comparison. The survey team have extensive personal and professional networks in intellectual disability and will promote the survey widely on social media with the support of local disability and advocacy agencies. Statistical descriptive and comparative analyses will be conducted. Ethical approval has been obtained for this study from University College Dublin's Human Research Ethics Committee (HS-20-28-Linehan). Dissemination: Study findings will be prepared in a number of formats in order to meet the needs of different audiences. Outputs will include academic papers, lessons learned paper, practice guidelines, reports, infographics and video content. These outputs will be directed to families, frontline and management delivering disability services, national-level policy makers, healthcare quality and delivery authorities, national pandemic organisations and international bodies.", "doi": "10.12688/hrbopenres.13077.1", "pmid": "33392440", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7745183"}], "notes": [], "created": "2021-01-05T15:17:20.252Z", "modified": "2021-02-26T08:46:59.862Z"}, {"entity": "publication", "iuid": "0ddad22d61894a518568a0db3ecbf194", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ddad22d61894a518568a0db3ecbf194.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ddad22d61894a518568a0db3ecbf194"}}, "title": "Creating misinformation: how a headline in The BMJ about covid-19 spread virally.", "authors": [{"family": "Winters", "given": "Maike", "initials": "M"}, {"family": "Oppenheim", "given": "Ben", "initials": "B"}, {"family": "Pick", "given": "Jonas", "initials": "J"}, {"family": "Nordenstedt", "given": "Helena", "initials": "H"}], "type": "letter", "published": "2020-06-18", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "369", "issue": null, "pages": "m2384", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m2384", "pmid": "32554782", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-09T07:46:47.709Z", "modified": "2020-12-09T07:46:47.718Z"}, {"entity": "publication", "iuid": "4c3bed3cd46f43f491164d00cd961e01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4c3bed3cd46f43f491164d00cd961e01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4c3bed3cd46f43f491164d00cd961e01"}}, "title": "The Coronavirus Pandemic and Lessons Learned in Preschools in Norway, Sweden and the United States: OMEP Policy Forum.", "authors": [{"family": "Pramling Samuelsson", "given": "Ingrid", "initials": "I"}, {"family": "Wagner", "given": "Judith T", "initials": "JT"}, {"family": "Eriksen \u00d8degaard", "given": "Elin", "initials": "E"}], "type": "journal article", "published": "2020-06-17", "journal": {"title": "Int J Early Child", "issn": "0020-7187", "volume": null, "issue": null, "pages": "1-16", "issn-l": null}, "abstract": "The novel coronavirus, also known as COVID-19, has moved rapidly across the world in 2020. This article reports on the recent consequences of the pandemic for early childhood education in Sweden, Norway, and the United States. The authors illustrate the effects of the pandemic on preschools in their countries, against a backdrop of frequent changes in infection and mortality rates, epidemiological understandings, government strategies, and mitigation strategies regarding preschool closures. Teachers report their experiences and actions in specific early childhood education settings, across the three national contexts. These experiential snapshots identify program priorities, parents' and children's reactions, and the commitment and concerns of teachers. The conversations reveal culturally situated similarities of early childhood educational practices but also differences across contexts. Teachers report on the challenges of their experiences but also benefits for their practice and how they engage with children and their families. Ideas about future preparedness for such pandemics are also discussed.", "doi": "10.1007/s13158-020-00267-3", "pmid": "32836368", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "267"}, {"db": "pmc", "key": "PMC7299556"}], "notes": [], "created": "2020-12-07T11:39:17.525Z", "modified": "2020-12-07T11:39:17.551Z"}, {"entity": "publication", "iuid": "49b89c9d3b9b4722899f24bbfcfa22fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49b89c9d3b9b4722899f24bbfcfa22fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49b89c9d3b9b4722899f24bbfcfa22fa"}}, "title": "Strategy for Disease Diagnosis, Progression Prediction, Risk Group Stratification and Treatment-Case of COVID-19.", "authors": [{"family": "Vihinen", "given": "Mauno", "initials": "M"}], "type": "journal article", "published": "2020-06-16", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "7", "issue": null, "pages": "294", "issn-l": null}, "abstract": "A novel strategy is presented for reliable diagnosis and progression prediction of diseases with special attention to COVID-19 pandemic. A plan is presented for how the model can be implemented worldwide in healthcare and how novel treatments and targets can be detected. The idea is based on poikilosis, pervasive heterogeneity, and variation at all levels, systems, and mechanisms. Poikilosis in diseases can be taken into account in pathogenicity model, which is based on distribution of three independent condition measures-extent, modulation, and severity. Pathogenicity model is a population or cohort-based description of disease components. Evidence-based thresholds can be applied to the pathogenicity model and used for diagnosis as well as for early detection of patients in risk of developing the most severe forms of the disease. Analysis of patients with differential course of disease can help in detecting biomarkers of diagnostic and prognostic significance. A practical and feasible plan is presented how the concepts can be implemented in practice. Collaboration of many actors, including the World Health Organization and national health authorities, will be essential for success.", "doi": "10.3389/fmed.2020.00294", "pmid": "32613004", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7308420"}], "notes": [], "created": "2020-12-08T15:19:35.899Z", "modified": "2020-12-08T15:19:35.908Z"}, {"entity": "publication", "iuid": "8a9bb861986d4d25b069df3861b0bc3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a9bb861986d4d25b069df3861b0bc3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a9bb861986d4d25b069df3861b0bc3d"}}, "title": "Ethical Criteria for the Admission and Management of Patients in the ICU Under Conditions of Limited Medical Resources: A Shared International Proposal in View of the COVID-19 Pandemic.", "authors": [{"family": "Tambone", "given": "Vittoradolfo", "initials": "V"}, {"family": "Boudreau", "given": "Donald", "initials": "D"}, {"family": "Ciccozzi", "given": "Massimo", "initials": "M"}, {"family": "Sanders", "given": "Karen", "initials": "K"}, {"family": "Campanozzi", "given": "Laura Leondina", "initials": "LL"}, {"family": "Wathuta", "given": "Jane", "initials": "J"}, {"family": "Violante", "given": "Luciano", "initials": "L"}, {"family": "Cauda", "given": "Roberto", "initials": "R"}, {"family": "Petrini", "given": "Carlo", "initials": "C"}, {"family": "Abbate", "given": "Antonio", "initials": "A"}, {"family": "Alloni", "given": "Rossana", "initials": "R"}, {"family": "Argemi", "given": "Josepmaria", "initials": "J"}, {"family": "Argem\u00ed Renom", "given": "Josep", "initials": "J"}, {"family": "De Benedictis", "given": "Anna", "initials": "A"}, {"family": "Galerneau", "given": "France", "initials": "F"}, {"family": "Garc\u00eda-S\u00e1nchez", "given": "Emilio", "initials": "E"}, {"family": "Ghilardi", "given": "Giampaolo", "initials": "G"}, {"family": "Hafler", "given": "Janet Palmer", "initials": "JP"}, {"family": "Linden", "given": "Magdalena", "initials": "M"}, {"family": "Marcos", "given": "Alfredo", "initials": "A"}, {"family": "Onetti Muda", "given": "Andrea", "initials": "A"}, {"family": "Pandolfi", "given": "Marco", "initials": "M"}, {"family": "Pelaccia", "given": "Thierry", "initials": "T"}, {"family": "Picozzi", "given": "Mario", "initials": "M"}, {"family": "Revello", "given": "Ruben Oscar", "initials": "RO"}, {"family": "Ricci", "given": "Giovanna", "initials": "G"}, {"family": "Rohrbaugh", "given": "Robert", "initials": "R"}, {"family": "Rossi", "given": "Patrizio", "initials": "P"}, {"family": "Sirignano", "given": "Ascanio", "initials": "A"}, {"family": "Spagnolo", "given": "Antonio Gioacchino", "initials": "AG"}, {"family": "Stammers", "given": "Trevor", "initials": "T"}, {"family": "Vel\u00e1zquez", "given": "Lourdes", "initials": "L"}, {"family": "Agazzi", "given": "Evandro", "initials": "E"}, {"family": "Mercurio", "given": "Mark", "initials": "M"}], "type": "journal article", "published": "2020-06-16", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "284", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2020.00284", "pmid": "32612972", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7308475"}], "notes": [], "created": "2020-12-08T15:20:15.113Z", "modified": "2020-12-08T15:20:15.122Z"}, {"entity": "publication", "iuid": "6e1934b517a94c6b8dad3b638f75caca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e1934b517a94c6b8dad3b638f75caca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e1934b517a94c6b8dad3b638f75caca"}}, "title": "Evaluation of the English Version of the Fear of COVID-19 Scale and Its Relationship with Behavior Change and Political Beliefs.", "authors": [{"family": "Winter", "given": "Taylor", "initials": "T"}, {"family": "Riordan", "given": "Benjamin C", "initials": "BC"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Mason", "given": "Andre", "initials": "A"}, {"family": "Poulgrain", "given": "John W", "initials": "JW"}, {"family": "Scarf", "given": "Damian", "initials": "D"}], "type": "journal article", "published": "2020-06-15", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "volume": null, "issue": null, "pages": "1-11", "issn-l": null}, "abstract": "The COVID-19 pandemic has many individuals around the world fearing for their lives. The constant news coverage, rapid transmission, and relatively high mortality rate, make fearfulness a natural response. To assess the fear of COVID-19, the Fear of COVID-19 Scale (FCV-19S) was developed. The primary aim of the present study was to conduct the first psychometric assessment and validation of the English version of the FCV-19S. Two samples were collected in New Zealand. Sample 1 comprised 1624 participants of which 1397 completed all questions and were used in the analyses. Sample 2 comprised 1111 participants of which 1023 completed all questions and were used in the analyses. Several psychometric tests were conducted to ascertain the scale's reliability and validity. Across both samples, the FCV-19S had high internal consistency. Consistent with the earlier validation studies, the FCV-19S displayed a moderately strong relationship with the perceived infectability and germ aversion subscales of the perceived vulnerability to disease scale (PVDS). Furthermore, FCV-19S scores were negatively correlated with the Warwick-Edinburgh Mental Wellbeing Scale (WEMWBS) scores. With respect to the motivating role of fear, there was a significant relationship between FCV-19S scores and adherence to the lockdown rules that were implemented in New Zealand. Finally, consistent with recent reports on the politicization of the COVID-19 pandemic, an exploratory question found that participants who rated themselves as more conservative tended to report lower FCV-19S scores. The English version of the COVID-19S is a sound unidimensional scale with robust psychometric properties and can be used with confidence among English-speaking populations.", "doi": "10.1007/s11469-020-00342-9", "pmid": "32837431", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "342"}, {"db": "pmc", "key": "PMC7295324"}], "notes": [], "created": "2020-12-07T10:35:30.325Z", "modified": "2021-02-26T08:45:48.294Z"}, {"entity": "publication", "iuid": "2d6e328ee4c3402cb4cf9ce713a48b68", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d6e328ee4c3402cb4cf9ce713a48b68.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d6e328ee4c3402cb4cf9ce713a48b68"}}, "title": "Analysing the Combined Health, Social and Economic Impacts of the Corovanvirus Pandemic Using Agent-Based Social Simulation.", "authors": [{"family": "Dignum", "given": "Frank", "initials": "F"}, {"family": "Dignum", "given": "Virginia", "initials": "V"}, {"family": "Davidsson", "given": "Paul", "initials": "P"}, {"family": "Ghorbani", "given": "Amineh", "initials": "A"}, {"family": "van der Hurk", "given": "Mijke", "initials": "M"}, {"family": "Jensen", "given": "Maarten", "initials": "M"}, {"family": "Kammler", "given": "Christian", "initials": "C"}, {"family": "Lorig", "given": "Fabian", "initials": "F"}, {"family": "Ludescher", "given": "Luis Gustavo", "initials": "LG"}, {"family": "Melchior", "given": "Alexander", "initials": "A"}, {"family": "Mellema", "given": "Ren\u00e9", "initials": "R"}, {"family": "Pastrav", "given": "Cezara", "initials": "C"}, {"family": "Vanhee", "given": "Lo\u00efs", "initials": "L"}, {"family": "Verhagen", "given": "Harko", "initials": "H"}], "type": "journal article", "published": "2020-06-15", "journal": {"title": "Minds Mach (Dordr)", "issn": "0924-6495", "volume": null, "issue": null, "pages": "1-18", "issn-l": null}, "abstract": "During the COVID-19 crisis there have been many difficult decisions governments and other decision makers had to make. E.g. do we go for a total lock down or keep schools open? How many people and which people should be tested? Although there are many good models from e.g. epidemiologists on the spread of the virus under certain conditions, these models do not directly translate into the interventions that can be taken by government. Neither can these models contribute to understand the economic and/or social consequences of the interventions. However, effective and sustainable solutions need to take into account this combination of factors. In this paper, we propose an agent-based social simulation tool, ASSOCC, that supports decision makers understand possible consequences of policy interventions, but exploring the combined social, health and economic consequences of these interventions.", "doi": "10.1007/s11023-020-09527-6", "pmid": "32836870", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "9527"}, {"db": "pmc", "key": "PMC7294191"}], "notes": [], "created": "2020-12-07T10:38:03.484Z", "modified": "2020-12-07T10:38:12.876Z"}, {"entity": "publication", "iuid": "e97cac63bbe14a28bca026bd3303fab7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e97cac63bbe14a28bca026bd3303fab7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e97cac63bbe14a28bca026bd3303fab7"}}, "title": "Rotational Thromboelastometry predicts care level in COVID-19", "authors": [{"family": "Almskog", "given": "Lou M", "initials": "LM"}, {"family": "Wikman", "given": "Agneta", "initials": "A"}, {"family": "Svensson", "given": "Jonas", "initials": "J"}, {"family": "Wanecek", "given": "Michael", "initials": "M"}, {"family": "Bottai", "given": "Matteo", "initials": "M"}, {"family": "van der Linden", "given": "Jan", "initials": "J"}, {"family": "\u00c5gren", "given": "Anna", "initials": "A"}], "type": "posted-content", "published": "2020-06-12", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.06.11.20128710", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-17T19:32:22.986Z", "modified": "2021-05-18T08:00:25.274Z"}, {"entity": "publication", "iuid": "8341c717ee3f4a4a98ccae033bcad53b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8341c717ee3f4a4a98ccae033bcad53b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8341c717ee3f4a4a98ccae033bcad53b"}}, "title": "Has Sweden's controversial covid-19 strategy been successful?", "authors": [{"family": "Habib", "given": "Heba", "initials": "H"}], "type": "journal article", "published": "2020-06-12", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "369", "issue": null, "pages": "m2376", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m2376", "pmid": "32532807", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-09T07:57:08.125Z", "modified": "2020-12-09T07:57:08.135Z"}, {"entity": "publication", "iuid": "0d5ace8c4e674605b00185201e9bfcbd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d5ace8c4e674605b00185201e9bfcbd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d5ace8c4e674605b00185201e9bfcbd"}}, "title": "COVID-19 pandemic: Practical considerations on the organization of an allergy clinic - an EAACI/ARIA Position Paper.", "authors": [{"family": "Pfaar", "given": "O", "initials": "O"}, {"family": "Klimek", "given": "L", "initials": "L"}, {"family": "Jutel", "given": "M", "initials": "M"}, {"family": "Akdis", "given": "C A", "initials": "CA"}, {"family": "Bousquet", "given": "J", "initials": "J"}, {"family": "Breiteneder", "given": "H", "initials": "H"}, {"family": "Chinthrajah", "given": "S", "initials": "S"}, {"family": "Diamant", "given": "Z", "initials": "Z"}, {"family": "Eiwegger", "given": "T", "initials": "T"}, {"family": "Fokkens", "given": "W J", "initials": "WJ"}, {"family": "Fritsch", "given": "H W", "initials": "HW"}, {"family": "Nadeau", "given": "K C", "initials": "KC"}, {"family": "O'Hehir", "given": "R E", "initials": "RE"}, {"family": "O'Mahony", "given": "L", "initials": "L"}, {"family": "Rief", "given": "W", "initials": "W"}, {"family": "Sampath", "given": "V", "initials": "V"}, {"family": "Schedlowski", "given": "M", "initials": "M"}, {"family": "Torres", "given": "M", "initials": "M"}, {"family": "Traidl-Hoffmann", "given": "C", "initials": "C"}, {"family": "Wang", "given": "D Y", "initials": "DY"}, {"family": "Zhang", "given": "L", "initials": "L"}, {"family": "Bonini", "given": "M", "initials": "M"}, {"family": "Brehler", "given": "R", "initials": "R"}, {"family": "Brough", "given": "H A", "initials": "HA"}, {"family": "Chivato", "given": "T", "initials": "T"}, {"family": "Del Giacco", "given": "S", "initials": "S"}, {"family": "Dramburg", "given": "S", "initials": "S"}, {"family": "Gawlik", "given": "R", "initials": "R"}, {"family": "Gelincik", "given": "A", "initials": "A"}, {"family": "Hoffmann-Sommergruber", "given": "K", "initials": "K"}, {"family": "Hox", "given": "V", "initials": "V"}, {"family": "Knol", "given": "E", "initials": "E"}, {"family": "Lauerma", "given": "A", "initials": "A"}, {"family": "Matricardi", "given": "P M", "initials": "PM"}, {"family": "Mortz", "given": "C G", "initials": "CG"}, {"family": "Ollert", "given": "M", "initials": "M"}, {"family": "Palomares", "given": "O", "initials": "O"}, {"family": "Riggioni", "given": "C", "initials": "C"}, {"family": "Schwarze", "given": "J", "initials": "J"}, {"family": "Skypala", "given": "I", "initials": "I"}, {"family": "Untersmayr", "given": "S", "initials": "S"}, {"family": "Walusiak-Skorupa", "given": "J", "initials": "J"}, {"family": "Ansotegui", "given": "I", "initials": "I"}, {"family": "Bachert", "given": "C", "initials": "C"}, {"family": "Bedbrook", "given": "A", "initials": "A"}, {"family": "Bosnic-Anticevich", "given": "S", "initials": "S"}, {"family": "Brussino", "given": "L", "initials": "L"}, {"family": "Canonica", "given": "G W", "initials": "GW"}, {"family": "Cardona", "given": "V", "initials": "V"}, {"family": "Carreiro-Martins", "given": "P", "initials": "P"}, {"family": "Cruz", "given": "A A", "initials": "AA"}, {"family": "Czarlewski", "given": "W", "initials": "W"}, {"family": "Fonseca", "given": "J A", "initials": "JA"}, {"family": "Gotua", "given": "M", "initials": "M"}, {"family": "Haatela", "given": "T", "initials": "T"}, {"family": "Ivancevich", "given": "J C", "initials": "JC"}, {"family": "Kuna", "given": "P", "initials": "P"}, {"family": "Kvedariene", "given": "V", "initials": "V"}, {"family": "Larenas-Linnemann", "given": "D", "initials": "D"}, {"family": "Latiff", "given": "A", "initials": "A"}, {"family": "Morais-Almeida", "given": "M", "initials": "M"}, {"family": "Mullol", "given": "J", "initials": "J"}, {"family": "Naclerio", "given": "R", "initials": "R"}, {"family": "Ohta", "given": "K", "initials": "K"}, {"family": "Okamoto", "given": "Y", "initials": "Y"}, {"family": "Onorato", "given": "G L", "initials": "GL"}, {"family": "Papadopoulos", "given": "N G", "initials": "NG"}, {"family": "Patella", "given": "V", "initials": "V"}, {"family": "Regateiro", "given": "F S", "initials": "FS"}, {"family": "Samolinski", "given": "B", "initials": "B"}, {"family": "Suppli Ulrik", "given": "C", "initials": "C"}, {"family": "Toppila-Salmi", "given": "S", "initials": "S"}, {"family": "Valiulis", "given": "A", "initials": "A"}, {"family": "Ventura", "given": "M T", "initials": "MT"}, {"family": "Yorgancioglu", "given": "A", "initials": "A"}, {"family": "Zuberbier", "given": "T", "initials": "T"}, {"family": "Agache", "given": "I", "initials": "I"}], "type": "journal article", "published": "2020-06-12", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": "76", "issue": "3", "pages": "648-676", "issn-l": "0105-4538"}, "abstract": "The Coronavirus disease 2019 (COVID-19) has evolved as a pandemic infectious disease transmitted by the severe acute respiratory syndrome coronavirus (SARS-CoV-)2. Allergists and other health care providers (HCPs) in the field of allergies and associated airway diseases are in the front line, taking care of patients potentially infected with SARS-CoV-2. Hence, strategies and practices to minimize risks of infection for both HCPs and treated patients have to be developed and followed by allergy clinics.\n\nThe scientific information on COVID-19 was analyzed by a literature search in Medline, Pubmed, national and international guidelines from the European Academy of Allergy and Clinical Immunology (EAACI), the Cochrane Library and the Internet.\n\nBased on diagnostic and treatment standards developed by EAACI, on international information regarding COVID-19, on guidelines of the World Health Organization (WHO) and other international organizations as well as on previous experience, a panel of experts including clinicians, psychologists, IT experts and basic scientists along with EAACI and the \"Allergic Rhinitis and its Impact on Asthma (ARIA)\" inititiative have developed recommendations for the optimal management of allergy clinics during the current COVID-19 pandemic. These recommendations are grouped into nine sections on different relevant aspects for the care of patients with allergies.\n\nThis international Position Paper provides recommendations on operational plans and procedures to maintain high standards in the daily clinical care of allergic patients whilst ensuring necessary safety in the current COVID-19 pandemic.", "doi": "10.1111/all.14453", "pmid": "32531110", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7323448"}], "notes": [], "created": "2020-11-25T09:59:36.828Z", "modified": "2021-04-23T16:11:47.867Z"}, {"entity": "publication", "iuid": "162889acebf541c4aa975e0920e09255", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/162889acebf541c4aa975e0920e09255.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/162889acebf541c4aa975e0920e09255"}}, "title": "Proteomic Profiling in Biracial Cohorts Implicates DC-SIGN as a Mediator of Genetic Risk in COVID-19", "authors": [{"family": "Katz", "given": "Daniel H", "initials": "DH", "orcid": "0000-0001-7237-8502", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b20cc0e5af5a45afbd1437ae5f67e1f9.json"}}, {"family": "Tahir", "given": "Usman A", "initials": "UA"}, {"family": "Ngo", "given": "Debby", "initials": "D"}, {"family": "Benson", "given": "Mark", "initials": "M"}, {"family": "Bick", "given": "Alexander G", "initials": "AG"}, {"family": "Pampana", "given": "Akhil", "initials": "A"}, {"family": "Gao", "given": "Yan", "initials": "Y"}, {"family": "Keyes", "given": "Michelle J", "initials": "MJ"}, {"family": "Correa", "given": "Adolfo", "initials": "A"}, {"family": "Sinha", "given": "Sumita", "initials": "S"}, {"family": "Shen", "given": "Dongxiao", "initials": "D"}, {"family": "Yang", "given": "Qiong", "initials": "Q"}, {"family": "Robbins", "given": "Jeremy M", "initials": "JM"}, {"family": "Chen", "given": "Zsu Zsu", "initials": "ZZ"}, {"family": "Cruz", "given": "Daniel E", "initials": "DE"}, {"family": "Peterson", "given": "Bennet", "initials": "B"}, {"family": "Natarajan", "given": "Pradeep", "initials": "P"}, {"family": "Vasan", "given": "Ramachandran S", "initials": "RS"}, {"family": "Smith", "given": "J Gustav", "initials": "JG"}, {"family": "Wang", "given": "Thomas J", "initials": "TJ"}, {"family": "Wilson", "given": "James G", "initials": "JG"}, {"family": "Gerszten", "given": "Robert E", "initials": "RE"}], "type": "posted-content", "published": "2020-06-11", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.06.09.20125690", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Health": null, "Category: Genomics & transcriptomics": null}, "xrefs": [], "notes": [], "created": "2021-06-17T07:59:56.735Z", "modified": "2021-06-17T08:00:14.173Z"}, {"entity": "publication", "iuid": "a11cb5cd27c844e589b01a7d4df0c679", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a11cb5cd27c844e589b01a7d4df0c679.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a11cb5cd27c844e589b01a7d4df0c679"}}, "title": "Associations Between Fear of COVID-19, Mental Health, and Preventive Behaviours Across Pregnant Women and Husbands: An Actor-Partner Interdependence Modelling.", "authors": [{"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Imani", "given": "Vida", "initials": "V"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Timpka", "given": "Toomas", "initials": "T"}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Updegraff", "given": "John A", "initials": "JA"}, {"family": "\u00c5restedt", "given": "Kristofer", "initials": "K"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2020-06-11", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "issn-l": null, "volume": null, "issue": null, "pages": "1-15"}, "abstract": "The present cross-sectional study examined the actor-partner interdependence effect of fear of COVID-19 among Iranian pregnant women and their husbands and its association with their mental health and preventive behaviours during the first wave of the COVID-19 pandemic in 2020. A total of 290 pregnant women and their husbands ( N = 580) were randomly selected from a list of pregnant women in the Iranian Integrated Health System and were invited to respond to psychometric scales assessing fear of COVID-19, depression, anxiety, suicidal intention, mental quality of life, and COVID-19 preventive behaviours. The findings demonstrated significant dyadic relationships between husbands and their pregnant wives' fear of COVID-19, mental health, and preventive behaviours. Pregnant wives' actor effect of fear of COVID-19 was significantly associated with depression, suicidal intention, mental quality of life, and COVID-19 preventive behaviours but not anxiety. Moreover, a husband actor effect of fear of COVID-19 was significantly associated with depression, anxiety, suicidal intention, mental quality of life, and COVID-19 preventive behaviours. Additionally, there were significant partner effects observed for both the pregnant wives and their husbands concerning all outcomes. The present study used a cross-sectional design and so is unable to determine the mechanism or causal ordering of the effects. Also, the data are mainly based on self-reported measures which have some limitations due to its potential for social desirability and recall biases. Based on the findings, couples may benefit from psychoeducation that focuses on the effect of mental health problems on pregnant women and the foetus.", "doi": "10.1007/s11469-020-00340-x", "pmid": "32837427", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "340"}, {"db": "pmc", "key": "PMC7289236"}], "notes": [], "created": "2020-12-07T10:36:04.681Z", "modified": "2021-02-26T08:47:00.131Z"}, {"entity": "publication", "iuid": "80ba3c6566dd4245b48fae35ee04d17a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/80ba3c6566dd4245b48fae35ee04d17a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/80ba3c6566dd4245b48fae35ee04d17a"}}, "title": "Two complementary model-based methods for calculating the risk of international spreading of a novel virus from the outbreak epicentre. The case of COVID-19.", "authors": [{"family": "Massad", "given": "Eduardo", "initials": "E"}, {"family": "Amaku", "given": "Marcos", "initials": "M"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Costa Dos Santos", "given": "Paulo Cesar", "initials": "PC"}, {"family": "Struchiner", "given": "Claudio Jose", "initials": "CJ"}, {"family": "Coutinho", "given": "Francisco Antonio Bezerra", "initials": "FAB"}], "type": "journal article", "published": "2020-06-09", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": "148", "issue": null, "pages": "e109", "issn-l": null}, "abstract": "We present two complementary model-based methods for calculating the risk of international spread of the novel coronavirus SARS-CoV-2 from the outbreak epicentre. One model aims to calculate the number of cases that would be exported from an endemic country to disease-free regions by travellers. The second model calculates the probability that an infected traveller will generate at least one secondary autochthonous case in the visited country. Although this paper focuses on the data from China, our methods can be adapted to calculate the risk of importation and subsequent outbreaks. We found an average R0 = 5.31 (ranging from 4.08 to 7.91) and a risk of spreading of 0.75 latent individuals per 1000 travellers. In addition, one infective traveller would be able to generate at least one secondary autochthonous case in the visited country with a probability of 23%.", "doi": "10.1017/S0950268820001223", "pmid": "32513345", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0950268820001223"}, {"db": "pmc", "key": "PMC7298081"}], "notes": [], "created": "2020-12-09T10:32:44.837Z", "modified": "2021-02-26T08:46:13.339Z"}, {"entity": "publication", "iuid": "bea00c18be9a4b858823b661f7fd1093", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bea00c18be9a4b858823b661f7fd1093.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bea00c18be9a4b858823b661f7fd1093"}}, "title": "Sampling bias and incorrect rooting make phylogenetic network tracing of SARS-COV-2 infections unreliable.", "authors": [{"family": "Mavian", "given": "Carla", "initials": "C", "orcid": "0000-0003-3819-5520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1480d0856ce148d49095321cc9c69977.json"}}, {"family": "Pond", "given": "Sergei Kosakovsky", "initials": "SK"}, {"family": "Marini", "given": "Simone", "initials": "S"}, {"family": "Magalis", "given": "Brittany Rife", "initials": "BR", "orcid": "0000-0001-6088-4651", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13ad1ff37ac54221bf1b1bbd68e37448.json"}}, {"family": "Vandamme", "given": "Anne-Mieke", "initials": "AM"}, {"family": "Dellicour", "given": "Simon", "initials": "S"}, {"family": "Scarpino", "given": "Samuel V", "initials": "SV", "orcid": "0000-0001-5716-2770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90b3b5f60b4745bda076bfa5c36e2201.json"}}, {"family": "Houldcroft", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1833-5285", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1058544bcab84e37b4e9442b80fbd398.json"}}, {"family": "Villabona-Arenas", "given": "Julian", "initials": "J"}, {"family": "Paisie", "given": "Taylor K", "initials": "TK", "orcid": "0000-0002-6024-2744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf0ca78109e2489eb19d25f2bb9d69c2.json"}}, {"family": "Trov\u00e3o", "given": "N\u00eddia S", "initials": "NS", "orcid": "0000-0002-2106-1166", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b13a1d1532074e8c812b4ad41600e17d.json"}}, {"family": "Boucher", "given": "Christina", "initials": "C"}, {"family": "Zhang", "given": "Yun", "initials": "Y"}, {"family": "Scheuermann", "given": "Richard H", "initials": "RH"}, {"family": "Gascuel", "given": "Olivier", "initials": "O"}, {"family": "Lam", "given": "Tommy Tsan-Yuk", "initials": "TT"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Abecasis", "given": "Ana", "initials": "A"}, {"family": "Wilkinson", "given": "Eduan", "initials": "E"}, {"family": "de Oliveira", "given": "Tulio", "initials": "T"}, {"family": "Bento", "given": "Ana I", "initials": "AI", "orcid": "0000-0001-7728-007X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4cc7effceac545aeb92eaa1dd0d8eea3.json"}}, {"family": "Schmidt", "given": "Heiko A", "initials": "HA", "orcid": "0000-0002-2311-8592", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e11b64fb6ed74b50ad88b6d6725c212b.json"}}, {"family": "Martin", "given": "Darren", "initials": "D"}, {"family": "Hadfield", "given": "James", "initials": "J"}, {"family": "Faria", "given": "Nuno", "initials": "N"}, {"family": "Grubaugh", "given": "Nathan D", "initials": "ND"}, {"family": "Neher", "given": "Richard A", "initials": "RA"}, {"family": "Baele", "given": "Guy", "initials": "G", "orcid": "0000-0002-1915-7732", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ed706bd4a744d8da6a2561880e98eba.json"}}, {"family": "Lemey", "given": "Philippe", "initials": "P"}, {"family": "Stadler", "given": "Tanja", "initials": "T"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Crandall", "given": "Keith A", "initials": "KA", "orcid": "0000-0002-0836-3389", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc79bb378b6b473abaa11659ec9620b9.json"}}, {"family": "Leitner", "given": "Thomas", "initials": "T", "orcid": "0000-0001-8160-2588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c26a4f8a2e204bc5930718c55a6d4a25.json"}}, {"family": "Stamatakis", "given": "Alexandros", "initials": "A"}, {"family": "Prosperi", "given": "Mattia", "initials": "M", "orcid": "0000-0002-9021-5595", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73d6b84d966e4738a7ab4556013b3a63.json"}}, {"family": "Salemi", "given": "Marco", "initials": "M"}], "type": "letter", "published": "2020-06-09", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "117", "issue": "23", "pages": "12522-12523", "issn-l": "0027-8424"}, "abstract": "Comment", "doi": "10.1073/pnas.2007295117", "pmid": "32381734", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7293693"}, {"db": "pii", "key": "2007295117"}], "notes": [], "created": "2020-11-25T07:31:25.225Z", "modified": "2023-06-19T15:37:57.813Z"}, {"entity": "publication", "iuid": "ae0bfe026d6d4e9c8821e05c1b33e008", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ae0bfe026d6d4e9c8821e05c1b33e008.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ae0bfe026d6d4e9c8821e05c1b33e008"}}, "title": "Clinical Characteristics of COVID-19 Patients With Gastrointestinal Symptoms: An Analysis of Seven Patients in China.", "authors": [{"family": "Ai", "given": "Jin-Wei", "initials": "JW"}, {"family": "Zi", "given": "Hao", "initials": "H"}, {"family": "Wang", "given": "Yong", "initials": "Y"}, {"family": "Huang", "given": "Qiao", "initials": "Q"}, {"family": "Wang", "given": "Na", "initials": "N"}, {"family": "Li", "given": "Lu-Yao", "initials": "LY"}, {"family": "Pei", "given": "Bin", "initials": "B"}, {"family": "Ji", "given": "Jianguang", "initials": "J"}, {"family": "Zeng", "given": "Xian-Tao", "initials": "XT"}], "type": "journal article", "published": "2020-06-09", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "7", "issue": null, "pages": "308", "issn-l": null}, "abstract": "Objectives: Patients with novel coronavirus disease 2019 (COVID-19) can present with gastrointestinal symptoms as their initial symptoms or as the main manifestations during disease progression, but the clinical characteristics of these patients are still unknown. Methods: We identified COVID-19 patients who admitted to Xiangyang No. 1 People's Hospital and presented with gastrointestinal symptoms as their initial or main symptoms. Their medical records were reviewed by two independent clinical scientists. The epidemiological and clinical characteristics as well as the clinical outcomes were analyzed. Results: Among 142 confirmed COVID-19 cases, 7 (4.9%) of them presented with gastrointestinal symptoms. Three patients had gastrointestinal symptoms as the initial symptoms and chief complaints, and 4 patients as the main symptoms during disease progression. Six patients had symptoms of diarrhea (3-16 days), 7 with anorexia (7-22 days), 6 with upper abdominal discomfort (1-7 days), and 4 with nausea (1-7 days), 1 with heartburn lasting 2 days, and 2 with vomiting symptoms (1 day). The chest CT scan showed typical COVID-19 imaging features, and associated with the progression of the disease. During treatment, 2 patients died due to organ failure. Discussion: COVID-19 patients with gastrointestinal symptoms are relatively rare and might be misdiagnosed. The clinical features include watery stools, anorexia, and upper abdominal discomfort. These patients may have severe disease and be associated with a poor prognosis. The underlying mechanisms of SARS-CoV-2 related gastrointestinal symptoms need to clarify in future studies.", "doi": "10.3389/fmed.2020.00308", "pmid": "32656221", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7325892"}], "notes": [], "created": "2020-12-08T14:15:30.089Z", "modified": "2021-02-26T08:45:48.571Z"}, {"entity": "publication", "iuid": "39cbb22196de4f19883ea00af5966044", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/39cbb22196de4f19883ea00af5966044.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/39cbb22196de4f19883ea00af5966044"}}, "title": "Correction: The challenge of COVID-19 and hematopoietic cell transplantation: EBMT recommendations for management of hematopoietic cell transplant recipients, their donors, and patients undergoing CAR T-cell therapy.", "authors": [{"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Mikulska", "given": "Malgorzata", "initials": "M"}, {"family": "de la Camara", "given": "Rafael", "initials": "R"}, {"family": "Basak", "given": "Grzegorz W", "initials": "GW"}, {"family": "Chabannon", "given": "Christian", "initials": "C"}, {"family": "Corbacioglu", "given": "Selim", "initials": "S"}, {"family": "Duarte", "given": "Rafael", "initials": "R"}, {"family": "Dolstra", "given": "Harry", "initials": "H"}, {"family": "Lankester", "given": "Arjan C", "initials": "AC"}, {"family": "Mohty", "given": "Mohamad", "initials": "M"}, {"family": "Montoto", "given": "Silvia", "initials": "S"}, {"family": "Murray", "given": "John", "initials": "J"}, {"family": "de Latour", "given": "R\u00e9gis Peffault", "initials": "RP"}, {"family": "Snowden", "given": "John A", "initials": "JA"}, {"family": "Yakoub-Agha", "given": "Ibrahim", "initials": "I"}, {"family": "Verhoeven", "given": "Bregje", "initials": "B"}, {"family": "Kr\u00f6ger", "given": "Nicolaus", "initials": "N"}, {"family": "Styczynski", "given": "Jan", "initials": "J"}, {"family": "European Society for Blood and Marrow Transplantation", "given": "", "initials": ""}], "type": "published erratum", "published": "2020-06-08", "journal": {"title": "Bone Marrow Transplant", "issn": "1476-5365", "volume": null, "issue": null, "issn-l": "0268-3369"}, "abstract": "An amendment to this paper has been published and can be accessed via a link at the top of the paper.", "doi": "10.1038/s41409-020-0965-7", "pmid": "32514158", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41409-020-0965-7"}, {"db": "pmc", "key": "PMC7278762"}], "notes": [], "created": "2020-11-25T09:56:54.993Z", "modified": "2020-12-09T10:32:02.389Z"}, {"entity": "publication", "iuid": "112efbced8284cb695c6852237f4b604", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/112efbced8284cb695c6852237f4b604.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/112efbced8284cb695c6852237f4b604"}}, "title": "The influence of the SARS-CoV-2 pandemic on esophagogastric cancer services: an international survey of esophagogastric surgeons.", "authors": [{"family": "Kamarajah", "given": "Sivesh K", "initials": "SK"}, {"family": "Markar", "given": "Sheraz R", "initials": "SR"}, {"family": "Singh", "given": "Pritam", "initials": "P"}, {"family": "Griffiths", "given": "Ewen A", "initials": "EA"}, {"family": "Oesophagogastric Anastomosis Audit Group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-06-05", "journal": {"title": "Dis Esophagus", "issn": "1442-2050", "issn-l": "1120-8694", "volume": null, "issue": null, "pages": null}, "abstract": "Several guidelines to guide clinical practice among esophagogastric surgeons during the COVID-19 pandemic were produced. However, none provide reflection of current service provision. This international survey aimed to clarify the changes observed in esophageal and gastric cancer management and surgery during the COVID-19 pandemic.\r\n\r\nAn online survey covering key areas for esophagogastric cancer services, including staging investigations and oncological and surgical therapy before and during (at two separate time-points-24th March 2020 and 18th April 2020) the COVID-19 pandemic were developed.\r\n\r\nA total of 234 respondents from 225 centers and 49 countries spanning six continents completed the first round of the online survey, of which 79% (n = 184) completed round 2. There was variation in the availability of staging investigations ranging from 26.5% for endoscopic ultrasound to 62.8% for spiral computed tomography scan. Definitive chemoradiotherapy was offered in 14.8% (adenocarcinoma) and 47.0% (squamous cell carcinoma) of respondents and significantly increased by almost three-fold and two-fold, respectively, in both round 1 and 2. There were uncertainty and heterogeneity surrounding prioritization of patients undergoing cancer resections. Of the surgeons symptomatic with COVID-19, only 40.2% (33/82) had routine access to COVID-19 polymerase chain reaction testing for staff. Of those who had testing available (n = 33), only 12.1% (4/33) had tested positive.\r\n\r\nThese data highlight management challenges and several practice variations in caring for patients with esophagogastric cancers. Therefore, there is a need for clear consistent guidelines to be in place in the event of a further pandemic to ensure a standardized level of oncological care for patients with esophagogastric cancers.", "doi": "10.1093/dote/doaa054", "pmid": "32500134", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "5851505"}, {"db": "pmc", "key": "PMC7314222"}], "notes": [], "created": "2020-11-25T09:44:08.645Z", "modified": "2022-11-10T07:53:55.709Z"}, {"entity": "publication", "iuid": "f8d08d0b526240e2b6ab9f13216bea3e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f8d08d0b526240e2b6ab9f13216bea3e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f8d08d0b526240e2b6ab9f13216bea3e"}}, "title": "Severe inflammation in children - cause for awareness during the current pandemic", "authors": [{"family": "Horne", "given": "AnnaCarin", "initials": "A"}, {"family": "Nordenh\u00e4ll", "given": "Lotta", "initials": "L"}], "type": "journal article", "published": "2020-06-05", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": "Clinical manifestations of COVID-19 in children are generally mild and many are asymptomatic. However, recent international reports have described clusters of children presenting with an unusual syndrome of high, persistent fever, severe inflammation and single- or multiorgan dysfunction, with a suspected association to COVID-19 pandemic. It is recommended that clinicians are aware of this rare syndrome and that suspected cases are treated in a multidisciplinary setting.", "doi": null, "pmid": "32542615", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "20094"}], "notes": [], "created": "2020-11-25T10:07:27.646Z", "modified": "2020-12-08T07:19:25.327Z"}, {"entity": "publication", "iuid": "5a3f35577cf0436ea0a28d8f046de55f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5a3f35577cf0436ea0a28d8f046de55f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5a3f35577cf0436ea0a28d8f046de55f"}}, "title": "Changes in Gambling Behavior during the COVID-19 Pandemic-A Web Survey Study in Sweden.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-06-05", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "11", "pages": null}, "abstract": "The COVID-19 pandemic has dramatically changed everyday life, and policy makers have raised concerns about possible changes in gambling patterns during the pandemic. This study aimed to examine whether self-reported gambling has increased during the pandemic, and to examine potential correlates of such a change. This general population survey study in Sweden collected self-report data from 2016 web survey members (51 percent men, nine percent moderate-risk/problem gamblers). Correlates of increased gambling and increased gambling specifically due to COVID-19-related cancellation of sports were calculated. Four percent reported an overall gambling increase during the pandemic. The proportion of individuals reporting an increase, compared to individuals reporting a decrease, was markedly higher for online casinos (0.62), online horse betting (0.76) and online lotteries (0.73), and lower for sports betting (0.11). Overall, gambling increases were independently associated with gambling problems and increased alcohol consumption. In the sub-group, where there was an increase in specific gambling types in response to cancelled sports betting events, rates of gambling problems were high. In conclusion, only a minority report increased gambling in response to the pandemic, but this group has markedly higher gambling problems and changes in alcohol consumption, and may represent a sub-group with a particularly high vulnerability. This calls for preventive action in people with higher gambling risks in response to the pandemic.", "doi": "10.3390/ijerph17114013", "pmid": "32516880", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "ijerph17114013"}, {"db": "pmc", "key": "PMC7312016"}], "notes": [], "created": "2020-12-09T10:30:11.240Z", "modified": "2022-11-10T07:54:17.524Z"}, {"entity": "publication", "iuid": "0be77bad07c449b1adfe016d20bbdcd6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0be77bad07c449b1adfe016d20bbdcd6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0be77bad07c449b1adfe016d20bbdcd6"}}, "title": "Detection of asymptomatic SARS-CoV-2 exposed individuals by a sensitive S-based ELISA", "authors": [{"family": "Rosendal", "given": "Ebba", "initials": "E"}, {"family": "Bystr\u00f6m", "given": "Julia Wigren", "initials": "JW"}, {"family": "Gr\u00f6ning", "given": "Remigius", "initials": "R"}, {"family": "Gwon", "given": "Yong Dae", "initials": "YD"}, {"family": "Nilsson", "given": "Emma", "initials": "E"}, {"family": "Sharma", "given": "Atin", "initials": "A"}, {"family": "Espaillat", "given": "Akbar", "initials": "A"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Thunberg", "given": "Therese", "initials": "T"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Puhar", "given": "Andrea", "initials": "A"}, {"family": "Cava", "given": "Felipe", "initials": "F"}, {"family": "Hedestam", "given": "Gunilla B Karlsson", "initials": "GBK"}, {"family": "Monsen", "given": "Tor", "initials": "T"}, {"family": "Elgh", "given": "Fredrik", "initials": "F"}, {"family": "Blomkvist", "given": "Bert", "initials": "B"}, {"family": "Marklund", "given": "Ingrid", "initials": "I"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Evander", "given": "Magnus", "initials": "M"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Johansson", "given": "Anders", "initials": "A"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "Forsell", "given": "Mattias NE", "initials": "MN", "orcid": "0000-0001-6904-742X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e41c0e1c9c7b499fb3d844d4c572e7bb.json"}}], "type": "posted-content", "published": "2020-06-04", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To assess the current coronavirus pandemic, there is a pressing need to determine the exposure and seroconversion to SARS-CoV-2 on a local and global level. Here, we demonstrate a sensitive and specific S-protein based assay that is well suited for detection of weak SARS- CoV-2-directed IgG responses, and that could identify exposed individuals with asymptomatic infection without the requirement of PCR diagnostics. Our results raise the possibility that on- going population-based studies using less sensitive state-of-the-art serological assays may significantly underestimate the frequency of exposure and seroconversion to SARS-CoV-2.", "doi": "10.1101/2020.06.02.20120477", "pmid": "32577692", "labels": {"Funder: KAW/SciLifeLab": null, "Funder: Vinnova": null, "Type: Preprint": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null, "Research Area: Host cell systems biology and targets": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-04T15:53:34.262Z", "modified": "2021-12-22T13:24:39.638Z"}, {"entity": "publication", "iuid": "4a19975d90fc4ffc8b4111c6836782d2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4a19975d90fc4ffc8b4111c6836782d2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4a19975d90fc4ffc8b4111c6836782d2"}}, "title": "The term \"physical distancing\" is recommended rather than \"social distancing\" during the COVID-19 pandemic for reducing feelings of rejection among people with mental health problems.", "authors": [{"family": "Wasserman", "given": "Danuta", "initials": "D"}, {"family": "van der Gaag", "given": "Rutger", "initials": "R"}, {"family": "Wise", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2020-06-01", "journal": {"title": "Eur Psychiatry", "issn": "1778-3585", "issn-l": "0924-9338", "volume": "63", "issue": "1", "pages": "e52"}, "abstract": "As COVID-19 has plagued our world, the term \"social distancing\" has been widely used with the aim to encourage the general population to physically distance themselves from others in order to reduce the spread of the virus. However, this term can have unintended but detrimental effects, as it evokes negative feelings of being ignored, unwelcome, left alone with one's own fears, and even excluded from society. These feelings may be stronger in people with mental illnesses and in socio-economically disadvantaged groups, such as stigmatized minorities, migrants, and homeless persons [1], many of them also having high risk for suicidal behaviors [2]. Mental health disorders are pervasive worldwide; the global burden accounting for approximately 21.2-32.4% of years lived with disability-more than any other group of illnesses [3]. So, the vulnerable group of people with mental health disorders represents a considerable share of the total global population.", "doi": "10.1192/j.eurpsy.2020.60", "pmid": "32475365", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0924933820000607"}, {"db": "pmc", "key": "PMC7287304"}], "notes": [], "created": "2020-11-25T09:29:57.335Z", "modified": "2022-11-10T07:54:44.175Z"}, {"entity": "publication", "iuid": "c1e74612a5d64ee89229777ca2d62d81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1e74612a5d64ee89229777ca2d62d81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1e74612a5d64ee89229777ca2d62d81"}}, "title": "Recommendations for the management of patients with immune-mediated kidney disease during the severe acute respiratory syndrome coronavirus 2 pandemic.", "authors": [{"family": "Anders", "given": "Hans-Joachim", "initials": "HJ"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Fernandez Juarez", "given": "Gema Maria", "initials": "GM"}, {"family": "Floege", "given": "J\u00fcrgen", "initials": "J"}, {"family": "Goumenos", "given": "Dimitrios", "initials": "D"}, {"family": "Turkmen", "given": "Kultigin", "initials": "K"}, {"family": "van Kooten", "given": "Cees", "initials": "C"}, {"family": "Tesar", "given": "Vladimir", "initials": "V"}, {"family": "Segelmark", "given": "M\u00e5rten", "initials": "M"}], "type": "journal article", "published": "2020-06-01", "journal": {"title": "Nephrol Dial Transplant", "issn": "1460-2385", "volume": "35", "issue": "6", "pages": "920-925", "issn-l": "0931-0509"}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has created major challenges for all countries around the globe. Retrospective studies have identified hypertension, cardiovascular disease, diabetes and older age as risk factors for high morbidity and mortality from COVID-19. There is a general concern that patients with immune-mediated kidney diseases, namely those on immunosuppressive therapies and/or those with more advanced kidney failure, could particularly be at risk for adverse outcomes due to a compromised antiviral immunity. Uncertainties exist on how management routines should be reorganized to minimize the risk of severe acute respiratory syndrome coronavirus 2 infection and what measures are necessary for infected patients. The aim of the present review of the Immunonephrology Working Group of the European Renal Association-European Dialysis and Transplant Association is to provide recommendations for the management of patients with immune-mediated kidney diseases based on the available evidence, similar circumstances with other infectious organisms and expert opinions from across Europe. Such recommendations may help to minimize the risk of encountering COVID-19 or developing complications during COVID-19 in patients with immune-mediated kidney disease.", "doi": "10.1093/ndt/gfaa112", "pmid": "32445573", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "5843427"}, {"db": "pmc", "key": "PMC7313759"}], "notes": [], "created": "2020-11-25T09:12:56.146Z", "modified": "2020-11-30T09:03:28.660Z"}, {"entity": "publication", "iuid": "d056cbfa81d345eb837ec8f343f8a79e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d056cbfa81d345eb837ec8f343f8a79e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d056cbfa81d345eb837ec8f343f8a79e"}}, "title": "Measurement of hydroxychloroquine in blood from SLE patients using LC-HRMS-evaluation of whole blood, plasma, and serum as sample matrices.", "authors": [{"family": "Carlsson", "given": "Henrik", "initials": "H"}, {"family": "Hjorton", "given": "Karin", "initials": "K"}, {"family": "Abujrais", "given": "Sandy", "initials": "S"}, {"family": "R\u00f6nnblom", "given": "Lars", "initials": "L"}, {"family": "\u00c5kerfeldt", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Kultima", "given": "Kim", "initials": "K"}], "type": "journal article", "published": "2020-06-01", "journal": {"title": "Arthritis Res Ther", "issn": "1478-6362", "volume": "22", "issue": "1", "pages": "125", "issn-l": "1478-6354"}, "abstract": "Hydroxychloroquine (HCQ) is the standard of care in the treatment of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and other inflammatory rheumatic diseases and potentially for the treatment in COVID-19 patients. Determination of HCQ for therapeutic drug monitoring (TDM) can be performed in whole blood (WB), serum, and plasma. Direct comparisons of WB, serum, and plasma levels of HCQ in patients with SLE have not previously been reported. We describe a method for the determination of HCQ in human blood using liquid chromatography-high-resolution mass spectrometry (LC-HRMS) and compare the suitability of the three sample matrices.\r\n\r\nA method for the determination of HCQ in human blood using LC-HRMS was developed, validated, and applied for the determination of HCQ levels in WB, serum, and plasma from 26 SLE patients. The reproducibility of the method, in the three matrices, was evaluated using quality control samples and repeated preparations and measurements of patient samples. The performance of the developed method for HCQ measurement in serum was further evaluated by comparison with two previously reported extraction methods.\r\n\r\nThe performance of the presented method demonstrated high accuracy and precision. A large range of HCQ concentrations was observed for the SLE patients in all three matrices (WB, serum, and plasma). The mean levels in WB were approximately two-fold the levels in serum and plasma (813 ng/mL compared to 436 ng/mL and 362 ng/mL, respectively). Spiked quality controls showed high reproducibility for all matrices (coefficient of variation, CV, approx. 5%), whereas in patient samples, equally high-precision was only found using WB as the matrix (CV 3%). The CV for serum and plasma was 14% and 39%, respectively. Two alternative methods applied to serum samples did not demonstrate improved precision.\r\n\r\nA LC-HRMS method for the measurement of HCQ in human blood was developed and validated. Whole blood was found to be the superior sample matrix in terms of sample reproducibility. Thus, whole blood samples should be used for HCQ analysis when patients are monitored for HCQ treatment effects. The assay is in clinical use to monitor levels of HCQ in patients.", "doi": "10.1186/s13075-020-02211-1", "pmid": "32475347", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13075-020-02211-1"}, {"db": "pmc", "key": "PMC7261520"}], "notes": [], "created": "2020-11-19T14:50:28.058Z", "modified": "2021-02-26T08:46:13.524Z"}, {"entity": "publication", "iuid": "9847a5d1a5084ca1b4ae55e88af59985", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9847a5d1a5084ca1b4ae55e88af59985.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9847a5d1a5084ca1b4ae55e88af59985"}}, "title": "Covid-19 - radiologic and histologic features", "authors": [{"family": "Mari Svensson", "given": "Ann", "initials": "A"}, {"family": "Hansen", "given": "Tomas", "initials": "T"}, {"family": "Nyren", "given": "Sven", "initials": "S"}, {"family": "Csatl\u00f3s", "given": "Martin", "initials": "M"}, {"family": "Brunnstr\u00f6m", "given": "Hans", "initials": "H"}], "type": "journal article", "published": "2020-06-01", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": "We here describe the current knowledge about the radiologic and histologic pulmonary features of covid-19, caused by SARS-CoV-2, and present lung histology from a case with fatal disease. Initial findings on computed tomography (CT) typically include peripheral multifocal bilateral ground-glass opacities, and correspondingly microscopic alveolar edema. This is followed by peripheral consolidations with air bronchogram and perilobular pattern on CT, signs of organizing pneumonia, corresponding to loose (potentially reversible) fibrosis. The posterior parts of the lungs and the lower lobes are typically more markedly affected. In severe disease with acute respiratory distress syndrome, thickened interlobular septa and crazy paving pattern appear on CT, which corresponds to histologic diffuse alveolar damage with, depending on the stage of the disease, features such as edema, hyaline membranes, reactive epithelium, inflammation, and fibrosis.", "doi": null, "pmid": "32484232", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "20086"}], "notes": [], "created": "2020-11-22T08:44:16.883Z", "modified": "2021-02-26T08:45:48.489Z"}, {"entity": "publication", "iuid": "e2b308acfdcf4885acf82db9e0f2c298", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2b308acfdcf4885acf82db9e0f2c298.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2b308acfdcf4885acf82db9e0f2c298"}}, "title": "[Covid-19: An ad hoc public health ethics consultation].", "authors": [{"family": "Wild", "given": "Verina", "initials": "V"}, {"family": "Buyx", "given": "Alena", "initials": "A"}, {"family": "Hurst", "given": "Samia", "initials": "S"}, {"family": "Munthe", "given": "Christian", "initials": "C"}, {"family": "Rid", "given": "Annette", "initials": "A"}, {"family": "Schr\u00f6der-B\u00e4ck", "given": "Peter", "initials": "P"}, {"family": "Strech", "given": "Daniel", "initials": "D"}, {"family": "Thompson", "given": "Alison", "initials": "A"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Gesundheitswesen", "issn": "1439-4421", "volume": "82", "issue": "6", "pages": "507-513", "issn-l": null}, "abstract": "In this paper we describe the process and content of our ad hoc public health ethics consultation for a Bavarian health authority in relation to Covid-19.", "doi": "10.1055/a-1174-0086", "pmid": "32604443", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7365938"}], "notes": [], "created": "2020-12-08T15:24:01.743Z", "modified": "2020-12-08T15:24:01.765Z"}, {"entity": "publication", "iuid": "793041f844bb47a6b0459f63b5bf4649", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/793041f844bb47a6b0459f63b5bf4649.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/793041f844bb47a6b0459f63b5bf4649"}}, "title": "Why is COVID-19 so mild in children?", "authors": [{"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}], "type": "editorial", "published": "2020-06-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": "109", "issue": "6", "pages": "1082-1083"}, "abstract": "Editorial", "doi": "10.1111/apa.15271", "pmid": "32212348", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-04T15:21:26.972Z", "modified": "2021-07-14T07:51:13.276Z"}, {"entity": "publication", "iuid": "f07fdb27688443f7a55e2521ea4aa933", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f07fdb27688443f7a55e2521ea4aa933.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f07fdb27688443f7a55e2521ea4aa933"}}, "title": "The importance of naturally attenuated SARS-CoV-2in the fight against COVID-19.", "authors": [{"family": "Armengaud", "given": "Jean", "initials": "J"}, {"family": "Delaunay-Moisan", "given": "Agn\u00e8s", "initials": "A"}, {"family": "Thuret", "given": "Jean-Yves", "initials": "JY"}, {"family": "van Anken", "given": "Eelco", "initials": "E"}, {"family": "Acosta-Alvear", "given": "Diego", "initials": "D"}, {"family": "Arag\u00f3n", "given": "Tom\u00e1s", "initials": "T"}, {"family": "Arias", "given": "Carolina", "initials": "C"}, {"family": "Blondel", "given": "Marc", "initials": "M"}, {"family": "Braakman", "given": "Ineke", "initials": "I"}, {"family": "Collet", "given": "Jean-Fran\u00e7ois", "initials": "JF"}, {"family": "Courcol", "given": "Ren\u00e9", "initials": "R"}, {"family": "Danchin", "given": "Antoine", "initials": "A"}, {"family": "Deleuze", "given": "Jean-Fran\u00e7ois", "initials": "JF"}, {"family": "Lavigne", "given": "Jean-Philippe", "initials": "JP"}, {"family": "Lucas", "given": "Sophie", "initials": "S"}, {"family": "Michiels", "given": "Thomas", "initials": "T"}, {"family": "Moore", "given": "Edward R B", "initials": "ERB"}, {"family": "Nixon-Abell", "given": "Jonathon", "initials": "J"}, {"family": "Rossello-Mora", "given": "Ramon", "initials": "R"}, {"family": "Shi", "given": "Zheng-Li", "initials": "ZL"}, {"family": "Siccardi", "given": "Antonio G", "initials": "AG"}, {"family": "Sitia", "given": "Roberto", "initials": "R"}, {"family": "Tillett", "given": "Daniel", "initials": "D"}, {"family": "Timmis", "given": "Kenneth N", "initials": "KN"}, {"family": "Toledano", "given": "Michel B", "initials": "MB"}, {"family": "van der Sluijs", "given": "Peter", "initials": "P"}, {"family": "Vicenzi", "given": "Elisa", "initials": "E"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Environ Microbiol", "issn": "1462-2920", "volume": "22", "issue": "6", "pages": "1997-2000", "issn-l": null}, "abstract": "The current SARS-CoV-2 pandemic is wreaking havoc throughout the world and has rapidly become a global health emergency. A central question concerning COVID-19 is why some individuals become sick and others not. Many have pointed already at variation in risk factors between individuals. However, the variable outcome of SARS-CoV-2 infections may, at least in part, be due also to differences between the viral subspecies with which individuals are infected. A more pertinent question is how we are to overcome the current pandemic. A vaccine against SARS-CoV-2 would offer significant relief, although vaccine developers have warned that design, testing and production of vaccines may take a year if not longer. Vaccines are based on a handful of different designs (i), but the earliest vaccines were based on the live, attenuated virus. As has been the case for other viruses during earlier pandemics, SARS-CoV-2 will mutate and may naturally attenuate over time (ii). What makes the current pandemic unique is that, thanks to state-of-the-art nucleic acid sequencing technologies, we can follow in detail how SARS-CoV-2 evolves while it spreads. We argue that knowledge of naturally emerging attenuated SARS-CoV-2 variants across the globe should be of key interest in our fight against the pandemic.", "doi": "10.1111/1462-2920.15039", "pmid": "32342578", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7267670"}], "notes": [], "created": "2020-12-10T07:13:58.995Z", "modified": "2020-12-10T07:14:16.138Z"}, {"entity": "publication", "iuid": "bc62516c1ade4b42900f062d118bf82a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bc62516c1ade4b42900f062d118bf82a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bc62516c1ade4b42900f062d118bf82a"}}, "title": "The disproportionate effect of COVID-19 mortality on ethnic minorities: Genetics or health inequalities?", "authors": [{"family": "El-Khatib", "given": "Ziad", "initials": "Z"}, {"family": "Jacobs", "given": "Graeme Brendon", "initials": "GB"}, {"family": "Ikomey", "given": "George Mondinde", "initials": "GM"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": "23", "issue": null, "pages": "100430", "issn-l": null}, "abstract": null, "doi": "10.1016/j.eclinm.2020.100430", "pmid": "32572393", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(20)30174-7"}, {"db": "pii", "key": "100430"}, {"db": "pmc", "key": "PMC7301807"}], "notes": [], "created": "2020-12-08T16:25:48.111Z", "modified": "2020-12-08T16:25:48.121Z"}, {"entity": "publication", "iuid": "65fdc6954fee4cacbb4b1282ea71421b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65fdc6954fee4cacbb4b1282ea71421b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65fdc6954fee4cacbb4b1282ea71421b"}}, "title": "The consequences of the COVID-19 pandemic for self-care in patients supported with a left ventricular assist device.", "authors": [{"family": "Ben Gal", "given": "Tuvia", "initials": "T"}, {"family": "Ben Avraham", "given": "Binyamin", "initials": "B"}, {"family": "Abu-Hazira", "given": "Miriam", "initials": "M"}, {"family": "Frigerio", "given": "Maria", "initials": "M"}, {"family": "Crespo-Leiro", "given": "Maria G", "initials": "MG"}, {"family": "Oppelaar", "given": "Anne Marie", "initials": "AM"}, {"family": "Kato", "given": "Naoko P", "initials": "NP"}, {"family": "Stromberg", "given": "Anna", "initials": "A"}, {"family": "Jaarsma", "given": "Tiny", "initials": "T"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Eur J Heart Fail", "issn": "1879-0844", "volume": "22", "issue": "6", "pages": "933-936", "issn-l": "1388-9842"}, "abstract": null, "doi": "10.1002/ejhf.1868", "pmid": "32391963", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7273102"}], "notes": [], "created": "2020-11-30T09:07:59.472Z", "modified": "2020-11-30T09:07:59.482Z"}, {"entity": "publication", "iuid": "30730f9295124a0ebe25fa06dd1e672e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/30730f9295124a0ebe25fa06dd1e672e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/30730f9295124a0ebe25fa06dd1e672e"}}, "title": "The Role of Pharmacovigilance and ISoP During the Global COVID-19 Pandemic.", "authors": [{"family": "Chandler", "given": "Rebecca E", "initials": "RE"}, {"family": "McCarthy", "given": "Deirdre", "initials": "D"}, {"family": "Delumeau", "given": "Jean-Christophe", "initials": "JC"}, {"family": "Harrison-Woolrych", "given": "Mira", "initials": "M"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Drug Saf", "issn": "1179-1942", "volume": "43", "issue": "6", "pages": "511-512", "issn-l": "0114-5916"}, "abstract": null, "doi": "10.1007/s40264-020-00941-4", "pmid": "32383008", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40264-020-00941-4"}, {"db": "pmc", "key": "PMC7203700"}], "notes": [], "created": "2020-12-10T07:39:37.185Z", "modified": "2020-12-10T07:44:48.952Z"}, {"entity": "publication", "iuid": "c1839231ec1844ed9ef55d3dc7eaf2fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1839231ec1844ed9ef55d3dc7eaf2fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1839231ec1844ed9ef55d3dc7eaf2fa"}}, "title": "Tackling two pandemics: a plea on World Tuberculosis Day.", "authors": [{"family": "Wingfield", "given": "Tom", "initials": "T"}, {"family": "Cuevas", "given": "Luis E", "initials": "LE"}, {"family": "MacPherson", "given": "Peter", "initials": "P"}, {"family": "Millington", "given": "Kerry A", "initials": "KA"}, {"family": "Squire", "given": "S Bertel", "initials": "SB"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "volume": "8", "issue": "6", "pages": "536-538", "issn-l": "2213-2600"}, "abstract": null, "doi": "10.1016/S2213-2600(20)30151-X", "pmid": "32220280", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(20)30151-X"}, {"db": "pmc", "key": "PMC7118542"}], "notes": [], "created": "2020-11-25T07:24:34.379Z", "modified": "2020-12-08T06:57:33.234Z"}, {"entity": "publication", "iuid": "8483b981df644399a2b16f6c0c276fa1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8483b981df644399a2b16f6c0c276fa1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8483b981df644399a2b16f6c0c276fa1"}}, "title": "Systematic review of COVID\u201019 in children shows milder cases and a better prognosis than adults", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "journal-article", "published": "2020-06-00", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "volume": "109", "issue": "6", "pages": "1088-1095", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has affected hundreds of thousands of people. Data on symptoms and prognosis in children are rare.\n\nA systematic literature review was carried out to identify papers on COVID-19, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), using the MEDLINE and Embase databases between January 1 and March 18, 2020.\n\nThe search identified 45 relevant scientific papers and letters. The review showed that children have so far accounted for 1%-5% of diagnosed COVID-19 cases, they often have milder disease than adults and deaths have been extremely rare. Diagnostic findings have been similar to adults, with fever and respiratory symptoms being prevalent, but fewer children seem to have developed severe pneumonia. Elevated inflammatory markers were less common in children, and lymphocytopenia seemed rare. Newborn infants have developed symptomatic COVID-19, but evidence of vertical intrauterine transmission was scarce. Suggested treatment included providing oxygen, inhalations, nutritional support and maintaining fluids and electrolyte balances.\n\nThe coronavirus disease 2019 has occurred in children, but they seemed to have a milder disease course and better prognosis than adults. Deaths were extremely rare.", "doi": "10.1111/apa.15270", "pmid": "32202343", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-04T13:20:33.860Z", "modified": "2020-12-10T09:00:20.059Z"}, {"entity": "publication", "iuid": "88f3f44ed037429b84b2679f50149fb2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/88f3f44ed037429b84b2679f50149fb2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/88f3f44ed037429b84b2679f50149fb2"}}, "title": "Surveillance to improve evidence for community control decisions during the COVID-19 pandemic - Opening the animal epidemic toolbox for Public Health.", "authors": [{"family": "Foddai", "given": "Alessandro", "initials": "A"}, {"family": "Lindberg", "given": "Ann", "initials": "A"}, {"family": "Lubroth", "given": "Juan", "initials": "J"}, {"family": "Ellis-Iversen", "given": "Johanne", "initials": "J"}], "type": "editorial", "published": "2020-06-00", "journal": {"title": "One Health", "issn": "2352-7714", "volume": "9", "issue": null, "pages": "100130", "issn-l": "2352-7714"}, "abstract": "During the first few months of 2020, the COVID-19 pandemic reached Europe and spread around the world. Health systems all over the world are trying to control the outbreak in the shortest possible time. Exotic disease outbreaks are not uncommon in animal health and randomised surveillance is frequently used as support for decision-making. This editorial discusses the possibilities of practicing One Health, by using methods from animal health to enhance surveillance for COVID-19 to provide an evidence base fort decision-making in communities and countries.", "doi": "10.1016/j.onehlt.2020.100130", "pmid": "32292816", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2352-7714(20)30046-X"}, {"db": "pii", "key": "100130"}, {"db": "pmc", "key": "PMC7104048"}], "notes": [], "created": "2020-12-09T12:07:55.701Z", "modified": "2020-12-09T12:07:55.711Z"}, {"entity": "publication", "iuid": "d3ccd047985d4acb94bac604fe32433c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3ccd047985d4acb94bac604fe32433c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3ccd047985d4acb94bac604fe32433c"}}, "title": "Sleep apnoea management in Europe during the COVID-19 pandemic: data from the European Sleep Apnoea Database (ESADA).", "authors": [{"family": "Grote", "given": "Ludger", "initials": "L"}, {"family": "McNicholas", "given": "Walter T", "initials": "WT"}, {"family": "Hedner", "given": "Jan", "initials": "J"}, {"family": "ESADA collaborators", "given": "", "initials": ""}], "type": "letter", "published": "2020-06-00", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "issn-l": "0903-1936", "volume": "55", "issue": "6", "pages": null}, "abstract": null, "doi": "10.1183/13993003.01323-2020", "pmid": "32366489", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "13993003.01323-2020"}, {"db": "pmc", "key": "PMC7236823"}], "notes": [], "created": "2020-12-10T07:27:06.019Z", "modified": "2022-11-10T07:57:10.670Z"}, {"entity": "publication", "iuid": "84d70442f23c48c0bd1adaf3746235fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84d70442f23c48c0bd1adaf3746235fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84d70442f23c48c0bd1adaf3746235fa"}}, "title": "Promoting healthy movement behaviours among children during the COVID-19 pandemic.", "authors": [{"family": "Guan", "given": "Hongyan", "initials": "H"}, {"family": "Okely", "given": "Anthony D", "initials": "AD"}, {"family": "Aguilar-Farias", "given": "Nicolas", "initials": "N"}, {"family": "Del Pozo Cruz", "given": "Borja", "initials": "B"}, {"family": "Draper", "given": "Catherine E", "initials": "CE"}, {"family": "El Hamdouchi", "given": "Asmaa", "initials": "A"}, {"family": "Florindo", "given": "Alex A", "initials": "AA"}, {"family": "J\u00e1uregui", "given": "Alejandra", "initials": "A"}, {"family": "Katzmarzyk", "given": "Peter T", "initials": "PT"}, {"family": "Kontsevaya", "given": "Anna", "initials": "A"}, {"family": "L\u00f6f", "given": "Marie", "initials": "M"}, {"family": "Park", "given": "Wonsoon", "initials": "W"}, {"family": "Reilly", "given": "John J", "initials": "JJ"}, {"family": "Sharma", "given": "Deepika", "initials": "D"}, {"family": "Tremblay", "given": "Mark S", "initials": "MS"}, {"family": "Veldman", "given": "Sanne L C", "initials": "SLC"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Lancet Child Adolesc Health", "issn": "2352-4650", "volume": "4", "issue": "6", "pages": "416-418", "issn-l": null}, "abstract": null, "doi": "10.1016/S2352-4642(20)30131-0", "pmid": "32458805", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2352-4642(20)30131-0"}, {"db": "pmc", "key": "PMC7190292"}], "notes": [], "created": "2020-12-09T11:04:29.834Z", "modified": "2020-12-09T11:04:29.857Z"}, {"entity": "publication", "iuid": "82eecfee1dc44f1384c78e45611f490c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82eecfee1dc44f1384c78e45611f490c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82eecfee1dc44f1384c78e45611f490c"}}, "title": "Population flow drives spatio-temporal distribution of COVID-19 in China.", "authors": [{"family": "Jia", "given": "Jayson S", "initials": "JS"}, {"family": "Lu", "given": "Xin", "initials": "X"}, {"family": "Yuan", "given": "Yun", "initials": "Y"}, {"family": "Xu", "given": "Ge", "initials": "G"}, {"family": "Jia", "given": "Jianmin", "initials": "J"}, {"family": "Christakis", "given": "Nicholas A", "initials": "NA"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "582", "issue": "7812", "pages": "389-394", "issn-l": "0028-0836"}, "abstract": "Sudden, large-scale and diffuse human migration can amplify localized outbreaks of disease into widespread epidemics 1-4. Rapid and accurate tracking of aggregate population flows may therefore be epidemiologically informative. Here we use 11,478,484 counts of mobile phone data from individuals leaving or transiting through the prefecture of Wuhan between 1 January and 24 January 2020 as they moved to 296 prefectures throughout mainland China. First, we document the efficacy of quarantine in ceasing movement. Second, we show that the distribution of population outflow from Wuhan accurately predicts the relative frequency and geographical distribution of infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) until 19 February 2020, across mainland China. Third, we develop a spatio-temporal 'risk source' model that leverages population flow data (which operationalize the risk that emanates from epidemic epicentres) not only to forecast the distribution of confirmed cases, but also to identify regions that have a high risk of transmission at an early stage. Fourth, we use this risk source model to statistically derive the geographical spread of COVID-19 and the growth pattern based on the population outflow from Wuhan; the model yields a benchmark trend and an index for assessing the risk of community transmission of COVID-19 over time for different locations. This approach can be used by policy-makers in any nation with available data to make rapid and accurate risk assessments and to plan the allocation of limited resources ahead of ongoing outbreaks.", "doi": "10.1038/s41586-020-2284-y", "pmid": "32349120", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://static-content.springer.com/esm/art%3A10.1038%2Fs41586-020-2284-y/MediaObjects/41586_2020_2284_MOESM3_ESM.xlsx", "description": "Population outflow data from Wuhan from January 1-24, 2020; COVID-19 case counts as of February 19 and other data for 296 prefectures in mainland China"}], "notes": [], "created": "2020-11-25T07:14:25.611Z", "modified": "2021-02-26T08:45:48.422Z"}, {"entity": "publication", "iuid": "035950dd9daf476c8b949f168f529119", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/035950dd9daf476c8b949f168f529119.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/035950dd9daf476c8b949f168f529119"}}, "title": "Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science.", "authors": [{"family": "Holmes", "given": "Emily A", "initials": "EA"}, {"family": "O'Connor", "given": "Rory C", "initials": "RC"}, {"family": "Perry", "given": "V Hugh", "initials": "VH"}, {"family": "Tracey", "given": "Irene", "initials": "I"}, {"family": "Wessely", "given": "Simon", "initials": "S"}, {"family": "Arseneault", "given": "Louise", "initials": "L"}, {"family": "Ballard", "given": "Clive", "initials": "C"}, {"family": "Christensen", "given": "Helen", "initials": "H"}, {"family": "Cohen Silver", "given": "Roxane", "initials": "R"}, {"family": "Everall", "given": "Ian", "initials": "I"}, {"family": "Ford", "given": "Tamsin", "initials": "T"}, {"family": "John", "given": "Ann", "initials": "A"}, {"family": "Kabir", "given": "Thomas", "initials": "T"}, {"family": "King", "given": "Kate", "initials": "K"}, {"family": "Madan", "given": "Ira", "initials": "I"}, {"family": "Michie", "given": "Susan", "initials": "S"}, {"family": "Przybylski", "given": "Andrew K", "initials": "AK"}, {"family": "Shafran", "given": "Roz", "initials": "R"}, {"family": "Sweeney", "given": "Angela", "initials": "A"}, {"family": "Worthman", "given": "Carol M", "initials": "CM"}, {"family": "Yardley", "given": "Lucy", "initials": "L"}, {"family": "Cowan", "given": "Katherine", "initials": "K"}, {"family": "Cope", "given": "Claire", "initials": "C"}, {"family": "Hotopf", "given": "Matthew", "initials": "M"}, {"family": "Bullmore", "given": "Ed", "initials": "E"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Lancet Psychiatry", "issn": "2215-0374", "volume": "7", "issue": "6", "pages": "547-560", "issn-l": "2215-0366"}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic is having a profound effect on all aspects of society, including mental health and physical health. We explore the psychological, social, and neuroscientific effects of COVID-19 and set out the immediate priorities and longer-term strategies for mental health science research. These priorities were informed by surveys of the public and an expert panel convened by the UK Academy of Medical Sciences and the mental health research charity, MQ: Transforming Mental Health, in the first weeks of the pandemic in the UK in March, 2020. We urge UK research funding agencies to work with researchers, people with lived experience, and others to establish a high level coordination group to ensure that these research priorities are addressed, and to allow new ones to be identified over time. The need to maintain high-quality research standards is imperative. International collaboration and a global perspective will be beneficial. An immediate priority is collecting high-quality data on the mental health effects of the COVID-19 pandemic across the whole population and vulnerable groups, and on brain function, cognition, and mental health of patients with COVID-19. There is an urgent need for research to address how mental health consequences for vulnerable groups can be mitigated under pandemic conditions, and on the impact of repeated media consumption and health messaging around COVID-19. Discovery, evaluation, and refinement of mechanistically driven interventions to address the psychological, social, and neuroscientific aspects of the pandemic are required. Rising to this challenge will require integration across disciplines and sectors, and should be done together with people with lived experience. New funding will be required to meet these priorities, and it can be efficiently leveraged by the UK's world-leading infrastructure. This Position Paper provides a strategy that may be both adapted for, and integrated with, research efforts in other countries.", "doi": "10.1016/S2215-0366(20)30168-1", "pmid": "32304649", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2215-0366(20)30168-1"}, {"db": "pmc", "key": "PMC7159850"}], "notes": [], "created": "2020-11-25T07:16:12.163Z", "modified": "2020-12-09T14:50:53.491Z"}, {"entity": "publication", "iuid": "e92ee2ee22ad4a6182b9acf7f3d86bee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e92ee2ee22ad4a6182b9acf7f3d86bee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e92ee2ee22ad4a6182b9acf7f3d86bee"}}, "title": "Infection prevention guidelines and considerations for paediatric risk groups when reopening primary schools during COVID-19 pandemic, Norway, April 2020.", "authors": [{"family": "Johansen", "given": "Tone Bjordal", "initials": "TB"}, {"family": "Astrup", "given": "Elisabeth", "initials": "E"}, {"family": "Jore", "given": "Solveig", "initials": "S"}, {"family": "Nilssen", "given": "Hege", "initials": "H"}, {"family": "Dahlberg", "given": "Bente Barton", "initials": "BB"}, {"family": "Klingenberg", "given": "Claus", "initials": "C"}, {"family": "Berg", "given": "Are Stuwitz", "initials": "AS"}, {"family": "Greve-Isdahl", "given": "Margrethe", "initials": "M"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "22", "issn-l": null}, "abstract": "In response to the coronavirus disease (COVID-19) pandemic, most countries implemented school closures. In Norway, schools closed on 13 March 2020. The evidence of effect on disease transmission was limited, while negative consequences were evident. Before reopening, risk-assessment for paediatric risk groups was performed, concluding that most children can attend school with few conditions requiring preventative homeschooling. We here present infection prevention and control guidelines for primary schools and recommendations for paediatric risk groups.", "doi": "10.2807/1560-7917.ES.2020.25.22.2000921", "pmid": "32524956", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7336110"}], "notes": [], "created": "2020-12-09T10:08:03.231Z", "modified": "2020-12-09T10:08:17.584Z"}, {"entity": "publication", "iuid": "b9f3736061384153b2c37590835ae09f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9f3736061384153b2c37590835ae09f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9f3736061384153b2c37590835ae09f"}}, "title": "Increased importance of digital medicine and eHealth during the Covid-19 pandemic.", "authors": [{"family": "Thulesius", "given": "Hans", "initials": "H"}], "type": "editorial", "published": "2020-06-00", "journal": {"title": "Scand J Prim Health Care", "issn": "1502-7724", "volume": "38", "issue": "2", "pages": "105-106", "issn-l": null}, "abstract": null, "doi": "10.1080/02813432.2020.1770466", "pmid": "32484725", "labels": {"Type: Other": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-09T10:54:36.128Z", "modified": "2021-02-26T08:45:48.615Z"}, {"entity": "publication", "iuid": "29f2b116641f4317b6d80f5bda3097b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/29f2b116641f4317b6d80f5bda3097b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/29f2b116641f4317b6d80f5bda3097b3"}}, "title": "Income security during public health emergencies: the COVID-19 poverty trap in Vietnam.", "authors": [{"family": "Tran", "given": "Phuong Bich", "initials": "PB"}, {"family": "Hensing", "given": "Gunnel", "initials": "G"}, {"family": "Wingfield", "given": "Tom", "initials": "T"}, {"family": "Atkins", "given": "Salla", "initials": "S"}, {"family": "Sidney Annerstedt", "given": "Kristi", "initials": "K"}, {"family": "Kazibwe", "given": "Joseph", "initials": "J"}, {"family": "Tomeny", "given": "Ewan", "initials": "E"}, {"family": "Biermann", "given": "Olivia", "initials": "O"}, {"family": "Thorpe", "given": "Jennifer", "initials": "J"}, {"family": "Forse", "given": "Rachel", "initials": "R"}, {"family": "L\u00f6nnroth", "given": "Knut", "initials": "K"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "5", "issue": "6", "pages": null, "issn-l": "2059-7908"}, "abstract": "Commentary", "doi": "10.1136/bmjgh-2020-002504", "pmid": "32540965", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-002504"}, {"db": "pmc", "key": "PMC7299029"}], "notes": [], "created": "2020-11-25T10:05:13.301Z", "modified": "2020-12-09T07:54:40.461Z"}, {"entity": "publication", "iuid": "958ff2339c9349c9adebb50b167376fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/958ff2339c9349c9adebb50b167376fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/958ff2339c9349c9adebb50b167376fa"}}, "title": "Income security during periods of ill health: a scoping review of policies, practice and coverage in low-income and middle-income countries.", "authors": [{"family": "Thorpe", "given": "Jennifer", "initials": "J"}, {"family": "Viney", "given": "Kerri", "initials": "K"}, {"family": "Hensing", "given": "Gunnel", "initials": "G"}, {"family": "L\u00f6nnroth", "given": "Knut", "initials": "K"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "5", "issue": "6", "issn-l": "2059-7908"}, "abstract": "The COVID-19 pandemic is a reminder that insufficient income security in periods of ill health leads to economic hardship for individuals and hampers disease control efforts as people struggle to stay home when sick or advised to observe quarantine. Evidence on income security during periods of ill health is growing but has not previously been reviewed as a full body of work concerning low-income and middle-income countries (LMICs). We performed a scoping review to map the range, features, coverage, protective effects and equity of policies that aim to provide income security for adults whose ill health prevents them from participating in gainful work. A total of 134 studies were included, providing data from 95% of LMICs. However, data across the majority of these countries were severely limited. Collectively the included studies demonstrate that coverage of contributory income-security schemes is low, especially for informal and low-income workers. Meanwhile, non-contributory schemes targeting low-income groups are often not explicitly designed to provide income support in periods of ill health, they can be difficult to access and rarely provide sufficient income support to cover the needs of eligible recipients. While identifying an urgent need for more research on illness-related income security in LMICs, this review concludes that scaling up and diversifying the range of income security interventions is crucial for improving coverage and equity. To achieve these outcomes, illness-related income protection must receive greater recognition in health policy and health financing circles, expanding our understanding of financial hardship beyond direct medical costs.", "doi": "10.1136/bmjgh-2020-002425", "pmid": "32540963", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-002425"}, {"db": "pmc", "key": "PMC7299014"}], "notes": [], "created": "2020-11-25T10:01:53.442Z", "modified": "2020-11-30T08:59:22.813Z"}, {"entity": "publication", "iuid": "601676ec450744c9b10e81a53394376d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/601676ec450744c9b10e81a53394376d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/601676ec450744c9b10e81a53394376d"}}, "title": "ISUOG Safety Committee Position Statement on use of personal protective equipment and hazard mitigation in relation to SARS-CoV-2 for practitioners undertaking obstetric and gynecological ultrasound.", "authors": [{"family": "Abramowicz", "given": "J S", "initials": "JS"}, {"family": "Basseal", "given": "J M", "initials": "JM"}, {"family": "Brezinka", "given": "C", "initials": "C"}, {"family": "Dall'Asta", "given": "A", "initials": "A"}, {"family": "Deng", "given": "J", "initials": "J"}, {"family": "Harrison", "given": "G", "initials": "G"}, {"family": "Lee", "given": "J C S", "initials": "JCS"}, {"family": "Lim", "given": "A", "initials": "A"}, {"family": "Mar\u0161al", "given": "K", "initials": "K"}, {"family": "Miloro", "given": "P", "initials": "P"}, {"family": "Poon", "given": "L C", "initials": "LC"}, {"family": "Salvesen", "given": "K \u00c5", "initials": "K\u00c5"}, {"family": "Sande", "given": "R", "initials": "R"}, {"family": "Ter Haar", "given": "G", "initials": "G"}, {"family": "Westerway", "given": "S C", "initials": "SC"}, {"family": "Xie", "given": "M X", "initials": "MX"}, {"family": "Lees", "given": "C", "initials": "C"}], "type": "consensus development conference", "published": "2020-06-00", "journal": {"title": "Ultrasound Obstet Gynecol", "issn": "1469-0705", "volume": "55", "issue": "6", "pages": "886-891", "issn-l": null}, "abstract": null, "doi": "10.1002/uog.22035", "pmid": "32255535", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7262197"}], "notes": [], "created": "2020-11-30T15:55:40.240Z", "modified": "2020-11-30T15:55:40.263Z"}, {"entity": "publication", "iuid": "1e769a312b144bada7f7438a482e40e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1e769a312b144bada7f7438a482e40e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1e769a312b144bada7f7438a482e40e2"}}, "title": "High impact of COVID-19 in long-term care facilities, suggestion for monitoring in the EU/EEA, May 2020.", "authors": [{"family": "ECDC Public Health Emergency Team", "given": "", "initials": ""}, {"family": "Danis", "given": "Kostas", "initials": "K"}, {"family": "Fonteneau", "given": "Laure", "initials": "L"}, {"family": "Georges", "given": "Scarlett", "initials": "S"}, {"family": "Daniau", "given": "C\u00f4me", "initials": "C"}, {"family": "Bernard-Stoecklin", "given": "Sibylle", "initials": "S"}, {"family": "Domegan", "given": "Lisa", "initials": "L"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}, {"family": "Hauge", "given": "Siri Helene", "initials": "SH"}, {"family": "Dequeker", "given": "Sara", "initials": "S"}, {"family": "Vandael", "given": "Eline", "initials": "E"}, {"family": "Van der Heyden", "given": "Johan", "initials": "J"}, {"family": "Renard", "given": "Fran\u00e7oise", "initials": "F"}, {"family": "Sierra", "given": "Natalia Bustos", "initials": "NB"}, {"family": "Ricchizzi", "given": "Enrico", "initials": "E"}, {"family": "Schweickert", "given": "Birgitta", "initials": "B"}, {"family": "Schmidt", "given": "Nicole", "initials": "N"}, {"family": "Abu Sin", "given": "Muna", "initials": "M"}, {"family": "Eckmanns", "given": "Tim", "initials": "T"}, {"family": "Paiva", "given": "Jos\u00e9-Artur", "initials": "JA"}, {"family": "Schneider", "given": "Elke", "initials": "E"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "22", "issn-l": null}, "abstract": "Residents in long-term care facilities (LTCF) are a vulnerable population group. Coronavirus disease (COVID-19)-related deaths in LTCF residents represent 30-60% of all COVID-19 deaths in many European countries. This situation demands that countries implement local and national testing, infection prevention and control, and monitoring programmes for COVID-19 in LTCF in order to identify clusters early, decrease the spread within and between facilities and reduce the size and severity of outbreaks.", "doi": "10.2807/1560-7917.ES.2020.25.22.2000956", "pmid": "32524949", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7336111"}], "notes": [], "created": "2020-12-09T10:08:38.057Z", "modified": "2020-12-09T10:08:38.067Z"}, {"entity": "publication", "iuid": "d0916465c57c4e368de76469fa6306d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d0916465c57c4e368de76469fa6306d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d0916465c57c4e368de76469fa6306d0"}}, "title": "Guidance for anti-VEGF intravitreal injections during the COVID-19 pandemic.", "authors": [{"family": "Korobelnik", "given": "Jean-Fran\u00e7ois", "initials": "JF"}, {"family": "Loewenstein", "given": "Anat", "initials": "A"}, {"family": "Eldem", "given": "Bora", "initials": "B"}, {"family": "Joussen", "given": "Antonia M", "initials": "AM"}, {"family": "Koh", "given": "Adrian", "initials": "A"}, {"family": "Lambrou", "given": "George N", "initials": "GN"}, {"family": "Lanzetta", "given": "Paolo", "initials": "P"}, {"family": "Li", "given": "Xiaoxin", "initials": "X"}, {"family": "L\u00f6vestam-Adrian", "given": "Monica", "initials": "M"}, {"family": "Navarro", "given": "Rafael", "initials": "R"}, {"family": "Okada", "given": "Annabelle A", "initials": "AA"}, {"family": "Pearce", "given": "Ian", "initials": "I"}, {"family": "Rodr\u00edguez", "given": "Francisco J", "initials": "FJ"}, {"family": "Wong", "given": "David T", "initials": "DT"}, {"family": "Wu", "given": "Lihteh", "initials": "L"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Graefes Arch Clin Exp Ophthalmol", "issn": "1435-702X", "volume": "258", "issue": "6", "pages": "1149-1156", "issn-l": null}, "abstract": "There is an urgent need to address how to best provide ophthalmic care for patients with retinal disease receiving intravitreal injections with anti-vascular endothelial growth factor agents during the ongoing global COVID-19 pandemic. This article provides guidance for ophthalmologists on how to deliver the best possible care for patients while minimizing the risk of infection.\n\nThe Vision Academy's Steering Committee of international retinal disease experts convened to discuss key considerations for managing patients with retinal disease during the COVID-19 pandemic. After reviewing the existing literature on the issue, members put forward recommendations that were systematically refined and voted on to develop this guidance.\n\nThe considerations focus on the implementation of steps to minimize the exposure of patients and healthcare staff to COVID-19. These include the use of personal protective equipment, adherence to scrupulous hygiene and disinfection protocols, pre-screening to identify symptomatic patients, and reducing the number of people in waiting rooms. Other important measures include triaging of patients to identify those at the greatest risk of irreversible vision loss and prioritization of treatment visits over monitoring visits where possible. In order to limit patient exposure, ophthalmologists should refrain from using treatment regimens that require frequent monitoring.\n\nManagement of patients with retinal disease receiving intravitreal injections during the COVID-19 pandemic will require adjustment to regular clinical practice to minimize the risk of exposure of patients and healthcare staff, and to prioritize those with the greatest medical need. The safety of patients and healthcare staff should be of paramount importance in all decision-making.", "doi": "10.1007/s00417-020-04703-x", "pmid": "32328757", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00417-020-04703-x"}, {"db": "pmc", "key": "PMC7179379"}], "notes": [], "created": "2020-11-30T15:53:13.584Z", "modified": "2020-11-30T15:53:13.608Z"}, {"entity": "publication", "iuid": "091411a45b3043e18f286c3dd9386cab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/091411a45b3043e18f286c3dd9386cab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/091411a45b3043e18f286c3dd9386cab"}}, "title": "From SARS to COVID-19: A previously unknown SARS- related coronavirus (SARS-CoV-2) of pandemic potential infecting humans - Call for a One Health approach.", "authors": [{"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "One Health", "issn": "2352-7714", "volume": "9", "issue": null, "pages": "100124", "issn-l": "2352-7714"}, "abstract": "Human coronaviruses continue to pose a threat to human health. The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019 which causes coronavirus disease-2019 (COVID-19), an acute respiratory disease marked the third introduction of a highly pathogenic coronavirus into the human population in the twenty-first century. This recent emergence of a previously unknown coronavirus in China leads to huge impacts on humans globally. Covid-19 is a challenge to global public health. Here, we discuss the COVID-19 outbreak in a one health context, highlighting the need for the implementation of one health measures and practices to improve human health and reduce the emergence of pandemic viruses.", "doi": "10.1016/j.onehlt.2020.100124", "pmid": "32195311", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2352-7714(20)30013-6"}, {"db": "pii", "key": "100124"}, {"db": "pmc", "key": "PMC7075990"}], "notes": [], "created": "2020-11-19T14:15:33.908Z", "modified": "2020-12-10T09:03:56.468Z"}, {"entity": "publication", "iuid": "7d9967664a4443e28cf52c8f6bf32d7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d9967664a4443e28cf52c8f6bf32d7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d9967664a4443e28cf52c8f6bf32d7a"}}, "title": "Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment.", "authors": [{"family": "Hrusak", "given": "Ondrej", "initials": "O"}, {"family": "Kalina", "given": "Tomas", "initials": "T"}, {"family": "Wolf", "given": "Joshua", "initials": "J"}, {"family": "Balduzzi", "given": "Adriana", "initials": "A"}, {"family": "Provenzi", "given": "Massimo", "initials": "M"}, {"family": "Rizzari", "given": "Carmelo", "initials": "C"}, {"family": "Rives", "given": "Susana", "initials": "S"}, {"family": "Del Pozo Carlavilla", "given": "Mar\u00eda", "initials": "M"}, {"family": "Alonso", "given": "Maria E V", "initials": "MEV"}, {"family": "Dom\u00ednguez-Pinilla", "given": "Nerea", "initials": "N"}, {"family": "Bourquin", "given": "Jean-Pierre", "initials": "JP"}, {"family": "Schmiegelow", "given": "Kjeld", "initials": "K"}, {"family": "Attarbaschi", "given": "Andishe", "initials": "A"}, {"family": "Grillner", "given": "Pernilla", "initials": "P"}, {"family": "Mellgren", "given": "Karin", "initials": "K"}, {"family": "van der Werff Ten Bosch", "given": "Jutte", "initials": "J"}, {"family": "Pieters", "given": "Rob", "initials": "R"}, {"family": "Brozou", "given": "Triantafyllia", "initials": "T"}, {"family": "Borkhardt", "given": "Arndt", "initials": "A"}, {"family": "Escherich", "given": "Gabriele", "initials": "G"}, {"family": "Lauten", "given": "Melchior", "initials": "M"}, {"family": "Stanulla", "given": "Martin", "initials": "M"}, {"family": "Smith", "given": "Owen", "initials": "O"}, {"family": "Yeoh", "given": "Allen E J", "initials": "AEJ"}, {"family": "Elitzur", "given": "Sarah", "initials": "S"}, {"family": "Vora", "given": "Ajay", "initials": "A"}, {"family": "Li", "given": "Chi-Kong", "initials": "CK"}, {"family": "Ariffin", "given": "Hany", "initials": "H"}, {"family": "Kolenova", "given": "Alexandra", "initials": "A"}, {"family": "Dallapozza", "given": "Luciano", "initials": "L"}, {"family": "Farah", "given": "Roula", "initials": "R"}, {"family": "Lazic", "given": "Jelena", "initials": "J"}, {"family": "Manabe", "given": "Atsushi", "initials": "A"}, {"family": "Styczynski", "given": "Jan", "initials": "J"}, {"family": "Kovacs", "given": "Gabor", "initials": "G"}, {"family": "Ottoffy", "given": "Gabor", "initials": "G"}, {"family": "Felice", "given": "Maria S", "initials": "MS"}, {"family": "Buldini", "given": "Barbara", "initials": "B"}, {"family": "Conter", "given": "Valentino", "initials": "V"}, {"family": "Stary", "given": "Jan", "initials": "J"}, {"family": "Schrappe", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Eur J Cancer", "issn": "1879-0852", "volume": "132", "issue": null, "pages": "11-16", "issn-l": "0959-8049"}, "abstract": "Since the beginning of COVID-19 pandemic, it is known that the severe course of the disease occurs mostly among the elderly, whereas it is rare among children and young adults. Comorbidities, in particular, diabetes and hypertension, clearly associated with age, besides obesity and smoke, are strongly associated with the need for intensive treatment and a dismal outcome. A weaker immunity of the elderly has been proposed as a possible explanation of this uneven age distribution. Thus, there is concern that children treated for cancer may allso be at risk for an unfavourable course of infection. Along the same line, anecdotal information from Wuhan, China, mentioned a severe course of COVID-19 in a child treated for leukaemia.\n\nWe made a flash survey on COVID-19 incidence and severity among children on anticancer treatment. Respondents were asked by email to fill in a short Web-based survey.\n\nWe received reports from 25 countries, where approximately 10,000 patients at risk are followed up. At the time of the survey, more than 200 of these children were tested, nine of whom were positive for COVID-19. Eight of the nine cases had asymptomatic to mild disease, and one was just diagnosed with COVID-19. We also discuss preventive measures that are in place or should be taken and treatment options in immunocompromised children with COVID-19.\n\nThus, even children receiving anticancer chemotherapy may have a mild or asymptomatic course of COVID-19. While we should not underestimate the risk of developing a more severe course of COVID-19 than that observed here, the intensity of preventive measures should not cause delays or obstructions in oncological treatment.", "doi": "10.1016/j.ejca.2020.03.021", "pmid": "32305831", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0959-8049(20)30162-3"}, {"db": "pmc", "key": "PMC7141482"}], "notes": [], "created": "2020-11-23T11:40:21.856Z", "modified": "2020-12-09T14:50:34.476Z"}, {"entity": "publication", "iuid": "8380e9f6f24d407083dc596516f81b09", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8380e9f6f24d407083dc596516f81b09.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8380e9f6f24d407083dc596516f81b09"}}, "title": "Festina lente: hydroxychloroquine, COVID-19 and the role of the rheumatologist.", "authors": [{"family": "Graef", "given": "Elizabeth R", "initials": "ER"}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Putman", "given": "Michael S", "initials": "MS"}, {"family": "Simard", "given": "Julia F", "initials": "JF"}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Berenbaum", "given": "Francis", "initials": "F"}, {"family": "Duarte-Garc\u00eda", "given": "Al\u00ed", "initials": "A"}, {"family": "Grainger", "given": "Rebecca", "initials": "R"}, {"family": "Harrison", "given": "Carly", "initials": "C"}, {"family": "Konig", "given": "Maximilian F", "initials": "MF"}, {"family": "Korsten", "given": "Peter", "initials": "P"}, {"family": "Proulx", "given": "Laurie", "initials": "L"}, {"family": "Richards", "given": "Dawn P", "initials": "DP"}, {"family": "Robinson", "given": "Philip C", "initials": "PC"}, {"family": "Sattui", "given": "Sebastian E", "initials": "SE"}, {"family": "Ugarte-Gil", "given": "Manuel Francisco", "initials": "MF"}, {"family": "Young", "given": "Kristen J", "initials": "KJ"}, {"family": "Kim", "given": "Alfred Hj", "initials": "AH"}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA"}, {"family": "COVID-19 Global Rheumatology Alliance", "given": "", "initials": ""}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Ann Rheum Dis", "issn": "1468-2060", "volume": "79", "issue": "6", "pages": "734-736", "issn-l": null}, "abstract": null, "doi": "10.1136/annrheumdis-2020-217480", "pmid": "32295786", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "annrheumdis-2020-217480"}, {"db": "pmc", "key": "PMC7359879"}, {"db": "mid", "key": "NIHMS1606969"}], "notes": [], "created": "2020-11-30T15:55:37.866Z", "modified": "2020-11-30T15:55:37.889Z"}, {"entity": "publication", "iuid": "c3cc1bf8901d417ba85873a09063b21e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3cc1bf8901d417ba85873a09063b21e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3cc1bf8901d417ba85873a09063b21e"}}, "title": "European Task Force on Atopic Dermatitis statement on severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection and atopic dermatitis.", "authors": [{"family": "Wollenberg", "given": "A", "initials": "A"}, {"family": "Flohr", "given": "C", "initials": "C"}, {"family": "Simon", "given": "D", "initials": "D"}, {"family": "Cork", "given": "M J", "initials": "MJ"}, {"family": "Thyssen", "given": "J P", "initials": "JP"}, {"family": "Bieber", "given": "T", "initials": "T"}, {"family": "de Bruin-Weller", "given": "M S", "initials": "MS"}, {"family": "Weidinger", "given": "S", "initials": "S"}, {"family": "Deleuran", "given": "M", "initials": "M"}, {"family": "Taieb", "given": "A", "initials": "A"}, {"family": "Paul", "given": "C", "initials": "C"}, {"family": "Trzeciak", "given": "M", "initials": "M"}, {"family": "Werfel", "given": "T", "initials": "T"}, {"family": "Seneschal", "given": "J", "initials": "J"}, {"family": "Barbarot", "given": "S", "initials": "S"}, {"family": "Darsow", "given": "U", "initials": "U"}, {"family": "Torrelo", "given": "A", "initials": "A"}, {"family": "Stalder", "given": "J-F", "initials": "JF"}, {"family": "Svensson", "given": "\u00c5", "initials": "\u00c5"}, {"family": "Hijnen", "given": "D", "initials": "D"}, {"family": "Gelmetti", "given": "C", "initials": "C"}, {"family": "Szalai", "given": "Z", "initials": "Z"}, {"family": "Gieler", "given": "U", "initials": "U"}, {"family": "De Raeve", "given": "L", "initials": "L"}, {"family": "Kunz", "given": "B", "initials": "B"}, {"family": "Spuls", "given": "P", "initials": "P"}, {"family": "von Kobyletzki", "given": "L B", "initials": "LB"}, {"family": "F\u00f6lster-Holst", "given": "R", "initials": "R"}, {"family": "Chernyshov", "given": "P V", "initials": "PV"}, {"family": "Christen-Zaech", "given": "S", "initials": "S"}, {"family": "Heratizadeh", "given": "A", "initials": "A"}, {"family": "Ring", "given": "J", "initials": "J"}, {"family": "Vestergaard", "given": "C", "initials": "C"}], "type": "letter", "published": "2020-06-00", "journal": {"title": "J Eur Acad Dermatol Venereol", "issn": "1468-3083", "volume": "34", "issue": "6", "pages": "e241-e242", "issn-l": null}, "abstract": null, "doi": "10.1111/jdv.16411", "pmid": "32223003", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-30T16:01:49.309Z", "modified": "2020-12-08T06:58:52.882Z"}, {"entity": "publication", "iuid": "f5f143610ed24ce6b388a493421004cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f5f143610ed24ce6b388a493421004cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f5f143610ed24ce6b388a493421004cc"}}, "title": "European Society of Minimally Invasive Neurological Therapy (ESMINT) recommendations for optimal interventional neurovascular management in the COVID-19 era.", "authors": [{"family": "Aggour", "given": "Mohamed", "initials": "M"}, {"family": "White", "given": "Phil", "initials": "P"}, {"family": "Kulcsar", "given": "Zsolt", "initials": "Z"}, {"family": "Fiehler", "given": "Jens", "initials": "J"}, {"family": "Brouwer", "given": "Patrick", "initials": "P"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "J Neurointerv Surg", "issn": "1759-8486", "volume": "12", "issue": "6", "pages": "542-544", "issn-l": "1759-8478"}, "abstract": null, "doi": "10.1136/neurintsurg-2020-016137", "pmid": "32303584", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "neurintsurg-2020-016137"}], "notes": [], "created": "2020-11-23T11:37:35.344Z", "modified": "2020-11-30T15:55:36.757Z"}, {"entity": "publication", "iuid": "11edc1b3690e4b4389108f054457a93d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/11edc1b3690e4b4389108f054457a93d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/11edc1b3690e4b4389108f054457a93d"}}, "title": "Drought and COVID-19 in the Eastern Mediterranean Region of the WHO.", "authors": [{"family": "Bellizzi", "given": "S", "initials": "S"}, {"family": "Panu Napodano", "given": "C M", "initials": "CM"}, {"family": "Fiamma", "given": "M", "initials": "M"}, {"family": "Ali Maher", "given": "O", "initials": "O"}], "type": "letter", "published": "2020-06-00", "journal": {"title": "Public Health", "issn": "1476-5616", "volume": "183", "issue": null, "pages": "46-47", "issn-l": null}, "abstract": null, "doi": "10.1016/j.puhe.2020.04.032", "pmid": "32422440", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0033-3506(20)30137-2"}, {"db": "pmc", "key": "PMC7205725"}], "notes": [], "created": "2020-12-09T11:45:41.328Z", "modified": "2020-12-09T11:45:41.338Z"}, {"entity": "publication", "iuid": "c39d8c784a284e0a9e934ca3053fcca1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c39d8c784a284e0a9e934ca3053fcca1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c39d8c784a284e0a9e934ca3053fcca1"}}, "title": "Diagnostic and digital solutions to address the COVID-19 pandemic: The need for international collaboration to close the gap.", "authors": [{"family": "Kyhlstedt", "given": "Mattias", "initials": "M"}, {"family": "Andersson", "given": "Sarah Wamala", "initials": "SW"}], "type": "editorial", "published": "2020-06-00", "journal": {"title": "Health Policy Technol", "issn": "2211-8837", "volume": "9", "issue": "2", "pages": "126-128", "issn-l": null}, "abstract": null, "doi": "10.1016/j.hlpt.2020.04.010", "pmid": "32341908", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2211-8837(20)30045-9"}, {"db": "pmc", "key": "PMC7182749"}], "notes": [], "created": "2020-12-10T07:11:46.097Z", "modified": "2020-12-10T07:12:14.626Z"}, {"entity": "publication", "iuid": "3395e910fcf34fa895cd0fc21ca7741d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3395e910fcf34fa895cd0fc21ca7741d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3395e910fcf34fa895cd0fc21ca7741d"}}, "title": "Chronic Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers Is High Among Intensive Care Unit Patients With Non-COVID-19 Sepsis but Carries a Moderately Increased Risk of Death.", "authors": [{"family": "Sunden-Cullberg", "given": "Jonas", "initials": "J"}], "type": "letter", "published": "2020-06-00", "journal": {"title": "Hypertension", "issn": "1524-4563", "volume": "75", "issue": "6", "pages": "e15-e16", "issn-l": "0194-911X"}, "abstract": "Comment", "doi": "10.1161/HYPERTENSIONAHA.120.15178", "pmid": "32275190", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7188028"}], "notes": [], "created": "2020-11-23T11:26:27.056Z", "modified": "2020-12-09T12:06:04.563Z"}, {"entity": "publication", "iuid": "fa6f8658e56447dd96deb89d7f60a796", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa6f8658e56447dd96deb89d7f60a796.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa6f8658e56447dd96deb89d7f60a796"}}, "title": "COVID-19 pandemic: Effects and evidence-based recommendations for otolaryngology and head and neck surgery practice.", "authors": [{"family": "Kowalski", "given": "Luiz P", "initials": "LP"}, {"family": "Sanabria", "given": "Alvaro", "initials": "A"}, {"family": "Ridge", "given": "John A", "initials": "JA"}, {"family": "Ng", "given": "Wai Tong", "initials": "WT"}, {"family": "de Bree", "given": "Remco", "initials": "R"}, {"family": "Rinaldo", "given": "Alessandra", "initials": "A"}, {"family": "Takes", "given": "Robert P", "initials": "RP"}, {"family": "M\u00e4kitie", "given": "Antti A", "initials": "AA"}, {"family": "Carvalho", "given": "Andre L", "initials": "AL"}, {"family": "Bradford", "given": "Carol R", "initials": "CR"}, {"family": "Paleri", "given": "Vinidh", "initials": "V"}, {"family": "Hartl", "given": "Dana M", "initials": "DM"}, {"family": "Vander Poorten", "given": "Vincent", "initials": "V"}, {"family": "Nixon", "given": "Iain J", "initials": "IJ"}, {"family": "Piazza", "given": "Cesare", "initials": "C"}, {"family": "Lacy", "given": "Peter D", "initials": "PD"}, {"family": "Rodrigo", "given": "Juan P", "initials": "JP"}, {"family": "Guntinas-Lichius", "given": "Orlando", "initials": "O"}, {"family": "Mendenhall", "given": "William M", "initials": "WM"}, {"family": "D'Cruz", "given": "Anil", "initials": "A"}, {"family": "Lee", "given": "Anne W M", "initials": "AWM"}, {"family": "Ferlito", "given": "Alfio", "initials": "A"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Head Neck", "issn": "1097-0347", "volume": "42", "issue": "6", "pages": "1259-1267", "issn-l": "1043-3074"}, "abstract": "The 2019 novel coronavirus disease (COVID-19) is a highly contagious zoonosis produced by SARS-CoV-2 that is spread human-to-human by respiratory secretions. It was declared by the WHO as a public health emergency. The most susceptible populations, needing mechanical ventilation, are the elderly and people with associated comorbidities. There is an important risk of contagion for anesthetists, dentists, head and neck surgeons, maxillofacial surgeons, ophthalmologists, and otolaryngologists. Health workers represent between 3.8% and 20% of the infected population; some 15% will develop severe complaints and among them, many will lose their lives. A large number of patients do not have overt signs and symptoms (fever/respiratory), yet pose a real risk to surgeons (who should know this fact and must therefore apply respiratory protective strategies for all patients they encounter). All interventions that have the potential to aerosolize aerodigestive secretions should be avoided or used only when mandatory. Health workers who are: pregnant, over 55 to 65 years of age, with a history of chronic diseases (uncontrolled hypertension, diabetes mellitus, chronic obstructive pulmonary diseases, and all clinical scenarios where immunosuppression is feasible, including that induced to treat chronic inflammatory conditions and organ transplants) should avoid the clinical attention of a potentially infected patient. Health care facilities should prioritize urgent and emergency visits and procedures until the present condition stabilizes; truly elective care should cease and discussed on a case-by-case basis for patients with cancer. For those who are working with COVID-19 infected patients' isolation is compulsory in the following settings: (a) unprotected close contact with COVID-19 pneumonia patients; (b) onset of fever, cough, shortness of breath, and other symptoms (gastrointestinal complaints, anosmia, and dysgeusia have been reported in a minority of cases). For any care or intervention in the upper aerodigestive tract region, irrespective of the setting and a confirmed diagnosis (eg, rhinoscopy or flexible laryngoscopy in the outpatient setting and tracheostomy or rigid endoscopy under anesthesia), it is strongly recommended that all health care personnel wear personal protective equipment such as N95, gown, cap, eye protection, and gloves. The procedures described are essential in trying to maintain safety of health care workers during COVID-19 pandemic. In particular, otolaryngologists, head and neck, and maxillofacial surgeons are per se exposed to the greatest risk of infection while caring for COVID-19 positive subjects, and their protection should be considered a priority in the present circumstances.", "doi": "10.1002/hed.26164", "pmid": "32270581", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7262203"}], "notes": [], "created": "2020-11-22T17:13:43.745Z", "modified": "2021-02-26T08:45:48.906Z"}, {"entity": "publication", "iuid": "53949d8569d644fea43526782295763e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53949d8569d644fea43526782295763e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53949d8569d644fea43526782295763e"}}, "title": "COVID-19 and urology: a comprehensive review of the literature.", "authors": [{"family": "Puliatti", "given": "Stefano", "initials": "S"}, {"family": "Eissa", "given": "Ahmed", "initials": "A"}, {"family": "Eissa", "given": "Radwa", "initials": "R"}, {"family": "Amato", "given": "Marco", "initials": "M"}, {"family": "Mazzone", "given": "Elio", "initials": "E"}, {"family": "Dell'Oglio", "given": "Paolo", "initials": "P"}, {"family": "Sighinolfi", "given": "Maria Chiara", "initials": "MC"}, {"family": "Zoeir", "given": "Ahmed", "initials": "A"}, {"family": "Micali", "given": "Salvatore", "initials": "S"}, {"family": "Bianchi", "given": "Giampaolo", "initials": "G"}, {"family": "Patel", "given": "Vipul", "initials": "V"}, {"family": "Wiklund", "given": "Peter", "initials": "P"}, {"family": "Coelho", "given": "Rafael F", "initials": "RF"}, {"family": "Bernhard", "given": "Jean-Christophe", "initials": "JC"}, {"family": "Dasgupta", "given": "Prokar", "initials": "P"}, {"family": "Mottrie", "given": "Alexandre", "initials": "A"}, {"family": "Rocco", "given": "Bernardo", "initials": "B"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "BJU Int", "issn": "1464-410X", "volume": "125", "issue": "6", "pages": "E7-E14", "issn-l": "1464-4096"}, "abstract": "To discuss the impact of COVID-19 on global health, particularly on urological practice and to review some of the available recommendations reported in the literature.\n\nIn the current narrative review the PubMed database was searched to identify all the related reports discussing the impact of COVID-19 on the urological field.\n\nThe COVID-19 pandemic is the latest and biggest global health threat. Medical and surgical priorities have changed dramatically to cope with the current challenge. These changes include postponements of all elective outpatient visits and surgical procedures to save facilities and resources for urgent cases and patients with COVID-19 patients. This review discuss some of the related changes in urology.\n\nOver the coming weeks, healthcare workers including urologists will be facing increasingly difficult challenges, and consequently, they should adopt triage strategy to avoid wasting of medical resources and they should endorse sufficient protection policies to guard against infection when dealing with COVID-19 patients.", "doi": "10.1111/bju.15071", "pmid": "32249538", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-22T17:05:52.843Z", "modified": "2020-12-09T11:49:47.884Z"}, {"entity": "publication", "iuid": "26126d85d88b4bfbb806f5648b298c2b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26126d85d88b4bfbb806f5648b298c2b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26126d85d88b4bfbb806f5648b298c2b"}}, "title": "COVID-19 and the policy sciences: initial reactions and perspectives", "authors": [{"family": "Weible", "given": "Christopher M", "initials": "CM"}, {"family": "Nohrstedt", "given": "Daniel", "initials": "D"}, {"family": "Cairney", "given": "Paul", "initials": "P"}, {"family": "Carter", "given": "David P", "initials": "DP"}, {"family": "Crow", "given": "Deserai A", "initials": "DA"}, {"family": "Durnov\u00e1", "given": "Anna P", "initials": "AP"}, {"family": "Heikkila", "given": "Tanya", "initials": "T"}, {"family": "Ingold", "given": "Karin", "initials": "K"}, {"family": "McConnell", "given": "Allan", "initials": "A"}, {"family": "Stone", "given": "Diane", "initials": "D"}], "type": "journal-article", "published": "2020-06-00", "journal": {"title": "Policy Sci", "issn": "0032-2687", "volume": "53", "issue": "2", "pages": "225-241", "issn-l": null}, "abstract": "The world is in the grip of a crisis that stands unprecedented in living memory. The COVID-19 pandemic is urgent, global in scale, and massive in impacts. Following Harold D. Lasswell's goal for the policy sciences to offer insights into unfolding phenomena, this commentary draws on the lessons of the policy sciences literature to understand the dynamics related to COVID-19. We explore the ways in which scientific and technical expertise, emotions, and narratives influence policy decisions and shape relationships among citizens, organizations, and governments. We discuss varied processes of adaptation and change, including learning, surges in policy responses, alterations in networks (locally and globally), implementing policies across transboundary issues, and assessing policy success and failure. We conclude by identifying understudied aspects of the policy sciences that deserve attention in the pandemic's aftermath.", "doi": "10.1007/s11077-020-09381-4", "pmid": "32313308", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "9381"}, {"db": "pmc", "key": "PMC7165254"}], "notes": [], "created": "2020-12-09T14:51:20.654Z", "modified": "2021-12-06T12:55:45.743Z"}, {"entity": "publication", "iuid": "e3b44608bd1a49b48f775d1281f565e6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3b44608bd1a49b48f775d1281f565e6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3b44608bd1a49b48f775d1281f565e6"}}, "title": "A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection", "authors": [{"family": "Casanova", "given": "Jean Laurent", "initials": "JL"}, {"family": "Su", "given": "Helen C", "initials": "HC"}, {"family": "Abel", "given": "Laurent", "initials": "L"}, {"family": "Aiuti", "given": "Alessandro", "initials": "A"}, {"family": "Almuhsen", "given": "Saleh", "initials": "S"}, {"family": "Arias", "given": "Andres Augusto", "initials": "AA"}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Biggs", "given": "Catherine", "initials": "C"}, {"family": "Bogunovic", "given": "Dusan", "initials": "D"}, {"family": "Boisson", "given": "Bertrand", "initials": "B"}, {"family": "Boisson-Dupuis", "given": "Stephanie", "initials": "S"}, {"family": "Bolze", "given": "Alexandre", "initials": "A"}, {"family": "Bondarenko", "given": "Anastasia", "initials": "A"}, {"family": "Bousfiha", "given": "Aziz", "initials": "A"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "Bustamante", "given": "Jacinta", "initials": "J"}, {"family": "Butte", "given": "Manish", "initials": "M"}, {"family": "Casari", "given": "Giorgio", "initials": "G"}, {"family": "Ciancanelli", "given": "Michael", "initials": "M"}, {"family": "Cobat", "given": "Aurelie", "initials": "A"}, {"family": "Condino-Neto", "given": "Antonio", "initials": "A"}, {"family": "Cooper", "given": "Megan", "initials": "M"}, {"family": "Dalgard", "given": "Clifton", "initials": "C"}, {"family": "Espinosa", "given": "Sara", "initials": "S"}, {"family": "Feldman", "given": "Hagit", "initials": "H"}, {"family": "Fellay", "given": "Jacques", "initials": "J"}, {"family": "Franco", "given": "Jose Luis", "initials": "JL"}, {"family": "Hagin", "given": "David", "initials": "D"}, {"family": "Itan", "given": "Yuval", "initials": "Y"}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E"}, {"family": "Lucas", "given": "Carrie", "initials": "C"}, {"family": "Mansouri", "given": "Davood", "initials": "D"}, {"family": "Meyts", "given": "Isabelle", "initials": "I"}, {"family": "Milner", "given": "Joshua", "initials": "J"}, {"family": "Mogensen", "given": "Trine", "initials": "T"}, {"family": "Morio", "given": "Tomohiro", "initials": "T"}, {"family": "Ng", "given": "Lisa", "initials": "L"}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD"}, {"family": "Okada", "given": "Satoshi", "initials": "S"}, {"family": "Ozcelik", "given": "Tayfun", "initials": "T"}, {"family": "Soler Palac\u00edn", "given": "Pere", "initials": "P"}, {"family": "Planas", "given": "Anna", "initials": "A"}, {"family": "Prando", "given": "Carolina", "initials": "C"}, {"family": "Puel", "given": "Anne", "initials": "A"}, {"family": "Pujol", "given": "Aurora", "initials": "A"}, {"family": "Redin", "given": "Claire", "initials": "C"}, {"family": "Renia", "given": "Laurent", "initials": "L"}, {"family": "Rodriguez Gallego", "given": "Jose Carlos", "initials": "JC"}, {"family": "Quintana-Murci", "given": "Lluis", "initials": "L"}, {"family": "Sancho-Shimizu", "given": "Vanessa", "initials": "V"}, {"family": "Sankaran", "given": "Vijay", "initials": "V"}, {"family": "Sepp\u00e4nen", "given": "Mikko R J", "initials": "MRJ"}, {"family": "Shahrooei", "given": "Mohammad", "initials": "M"}, {"family": "Snow", "given": "Andrew", "initials": "A"}, {"family": "Spaan", "given": "Andr\u00e1s", "initials": "A"}, {"family": "Tangye", "given": "Stuart", "initials": "S"}, {"family": "Tur", "given": "Jordi Perez", "initials": "JP"}, {"family": "Turvey", "given": "Stuart", "initials": "S"}, {"family": "Vinh", "given": "Donald C", "initials": "DC"}, {"family": "von Bernuth", "given": "Horst", "initials": "H"}, {"family": "Wang", "given": "Xiaochuan", "initials": "X"}, {"family": "Zawadzki", "given": "Pawel", "initials": "P"}, {"family": "Zhang", "given": "Qian", "initials": "Q"}, {"family": "Zhang", "given": "Shenying", "initials": "S"}], "type": "journal-article", "published": "2020-06-00", "journal": {"title": "Cell", "issn": "0092-8674", "issn-l": null, "volume": "181", "issue": "6", "pages": "1194-1199"}, "abstract": null, "doi": "10.1016/j.cell.2020.05.016", "pmid": null, "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [], "notes": [], "created": "2021-01-08T14:42:51.655Z", "modified": "2021-02-26T08:45:14.484Z"}, {"entity": "publication", "iuid": "c1a203b527b147eb9c8b072439cb950d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1a203b527b147eb9c8b072439cb950d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1a203b527b147eb9c8b072439cb950d"}}, "title": "COVID-19 Pandemic: What Can the West Learn From the East?", "authors": [{"family": "Shokoohi", "given": "Mostafa", "initials": "M"}, {"family": "Osooli", "given": "Mehdi", "initials": "M"}, {"family": "Stranges", "given": "Saverio", "initials": "S"}], "type": "journal article", "published": "2020-05-31", "journal": {"title": "Int J Health Policy Manag", "issn": "2322-5939", "volume": null, "issue": null, "issn-l": null}, "abstract": "Differences in public health approaches to control the coronavirus disease 2019 (COVID-19) pandemic could largely explain substantial variations in epidemiological indicators (such as incidence and mortality) between the West and the East. COVID-19 revealed vulnerabilities of most western countries' healthcare systems in their response to the ongoing public health crisis. Hence, western countries can possibly learn from practices from several East Asian countries regarding infrastructures, epidemiological surveillance and control strategies to mitigate the public health impact of the pandemic. In this paper, we discuss that the lack of rapid and timely community-centered approaches, and most importantly weak public health infrastructures, might have resulted in a high number of infected cases and fatalities in many western countries.", "doi": "10.34172/ijhpm.2020.85", "pmid": "32610736", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-08T15:21:17.919Z", "modified": "2020-12-08T15:21:17.941Z"}, {"entity": "publication", "iuid": "2d3174860b5c42748add3b95c71de385", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d3174860b5c42748add3b95c71de385.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d3174860b5c42748add3b95c71de385"}}, "title": "The invisible pandemic.", "authors": [{"family": "Giesecke", "given": "Johan", "initials": "J"}], "type": "letter", "published": "2020-05-30", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "395", "issue": "10238", "pages": "e98", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)31035-7", "pmid": "32539940", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31035-7"}, {"db": "pmc", "key": "PMC7200128"}], "notes": [], "created": "2020-11-25T10:01:09.416Z", "modified": "2020-12-09T07:55:20.718Z"}, {"entity": "publication", "iuid": "f7811fd8913f43e78c16e387fc37e5f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7811fd8913f43e78c16e387fc37e5f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7811fd8913f43e78c16e387fc37e5f0"}}, "title": "Low prevalence of SARS-CoV-2 among pregnant and postpartum patients with universal screening in Seattle, Washington.", "authors": [{"family": "LaCourse", "given": "Sylvia M", "initials": "SM"}, {"family": "Kachikis", "given": "Alisa", "initials": "A"}, {"family": "Blain", "given": "Michela", "initials": "M"}, {"family": "Simmons", "given": "LaVone E", "initials": "LE"}, {"family": "Mays", "given": "James A", "initials": "JA"}, {"family": "Pattison", "given": "Amber D", "initials": "AD"}, {"family": "Salerno", "given": "Carol C", "initials": "CC"}, {"family": "McCartney", "given": "Stephen A", "initials": "SA"}, {"family": "Kretzer", "given": "Nicole M", "initials": "NM"}, {"family": "Resnick", "given": "Rebecca", "initials": "R"}, {"family": "Shay", "given": "Rosemary L", "initials": "RL"}, {"family": "Savitsky", "given": "Leah M", "initials": "LM"}, {"family": "Curtin", "given": "Anna C", "initials": "AC"}, {"family": "Huebner", "given": "Emily M", "initials": "EM"}, {"family": "Ma", "given": "Kimberly K", "initials": "KK"}, {"family": "Delaney", "given": "Shani", "initials": "S"}, {"family": "Delgado", "given": "Carlos", "initials": "C"}, {"family": "Schippers", "given": "Adrienne", "initials": "A"}, {"family": "Munson", "given": "Jeff", "initials": "J"}, {"family": "Pottinger", "given": "Paul S", "initials": "PS"}, {"family": "Cohen", "given": "Seth", "initials": "S"}, {"family": "Neme", "given": "Santiago", "initials": "S"}, {"family": "Bourassa", "given": "Lori", "initials": "L"}, {"family": "Bryan", "given": "Andrew", "initials": "A"}, {"family": "Greninger", "given": "Alex", "initials": "A"}, {"family": "Jerome", "given": "Keith R", "initials": "KR"}, {"family": "Roxby", "given": "Alison C", "initials": "AC"}, {"family": "Lokken", "given": "Erica", "initials": "E"}, {"family": "Cheng", "given": "Edith", "initials": "E"}, {"family": "Adams Waldorf", "given": "Kristina M", "initials": "KM"}, {"family": "Hitti", "given": "Jane", "initials": "J"}], "type": "journal article", "published": "2020-05-30", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "volume": null, "issue": null, "issn-l": "1058-4838"}, "abstract": "We found a low prevalence of SARS-CoV-2 (2.7% [5/188]) among pregnant and postpartum patients after initiating universal testing. Prevalence among symptomatic patients (22.2% [4/18]) was similar to initial targeted screening approaches (19.1% [8/42]). Among 170 asymptomatic patients, two were positive or inconclusive, respectively; repeat testing at 24 hours was negative.", "doi": "10.1093/cid/ciaa675", "pmid": "32472688", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "5848913"}, {"db": "pmc", "key": "PMC7314151"}], "notes": [], "created": "2020-12-09T11:02:45.999Z", "modified": "2021-02-26T08:45:48.879Z"}, {"entity": "publication", "iuid": "619f0e5a1caf46a19db29becd97df2c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/619f0e5a1caf46a19db29becd97df2c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/619f0e5a1caf46a19db29becd97df2c9"}}, "title": "Effect of COVID-19 response in Uganda on street children", "authors": [{"family": "Kawala", "given": "Brenda Allen", "initials": "BA"}, {"family": "Kirui", "given": "Brian Kibiwott", "initials": "BK"}, {"family": "Cumber", "given": "Samuel Nambile", "initials": "SN"}], "type": "journal-article", "published": "2020-05-29", "journal": {"title": "Pan Afr Med J", "issn": "1937-8688", "volume": "35", "issue": "Supp 2", "pages": "56", "issn-l": null}, "abstract": null, "doi": "10.11604/pamj.supp.2020.35.2.23545", "pmid": "33623581", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-25T10:10:48.886Z", "modified": "2021-02-25T10:11:23.119Z"}, {"entity": "publication", "iuid": "71cc0f9b690a4930a5aa7d9d71e51587", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/71cc0f9b690a4930a5aa7d9d71e51587.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/71cc0f9b690a4930a5aa7d9d71e51587"}}, "title": "Assessing Psychological Response to the COVID-19: The Fear of COVID-19 Scale and the COVID Stress Scales.", "authors": [{"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}], "type": "journal article", "published": "2020-05-29", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "volume": null, "issue": null, "pages": "1-4", "issn-l": null}, "abstract": null, "doi": "10.1007/s11469-020-00334-9", "pmid": "32837424", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "334"}, {"db": "pmc", "key": "PMC7259433"}], "notes": [], "created": "2020-12-07T10:36:43.662Z", "modified": "2020-12-07T10:36:43.672Z"}, {"entity": "publication", "iuid": "0920ab25f86e4d27a1b9f3378fa735b8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0920ab25f86e4d27a1b9f3378fa735b8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0920ab25f86e4d27a1b9f3378fa735b8"}}, "title": "Serological tests should be related to the aim of the testing, as well as the population.", "authors": [{"family": "Modig", "given": "Karin", "initials": "K"}, {"family": "Gem\u00e9s", "given": "Katalin", "initials": "K"}, {"family": "Feychting", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2020-05-27", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": "Expectations are high on serological tests for SARS-CoV-2. Further knowledge of the immunity is needed, but also evaluation of the reliability of the tests. Important for the latter is for which purpose the test is conducted and how common the outcome to be identified is (antibodies). For the determination of immunity at the individual level, the specificity of the test must be very high, preferably 100%. Even tests where the specificity is perceived as high, e.g. 95% or 99%, can lead to a large proportion of false positives, if the proportion of the population actually infected is small.", "doi": null, "pmid": "32463477", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "20081"}], "notes": [], "created": "2020-11-25T08:22:02.643Z", "modified": "2023-06-19T14:48:59.968Z"}, {"entity": "publication", "iuid": "a9b5a357258d4cec9ee60f09d0a2dc3b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a9b5a357258d4cec9ee60f09d0a2dc3b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a9b5a357258d4cec9ee60f09d0a2dc3b"}}, "title": "Rapid point-of-care serology testing for sars-cov-2", "authors": [{"family": "Stackelberg", "given": "Otto", "initials": "O"}, {"family": "Esmaeilzadeh", "given": "Mouna", "initials": "M"}, {"family": "Olsen", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "journal article", "published": "2020-05-27", "journal": {"title": "L\u00e4kartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": "Increasing evidence indicates immunity against severe acute respiratory syndrome coronavirus 2 (sars-cov-2) after covid-19, but it remains unclear for how long the protection remains. Serology testing seems to have a higher sensitivity than molecular diagnostics from 8 days after onset of symtoms, and should be part of risk assessment and epidemiological studies of COVID-19. The performance of commercial serological point-of-care (POC) lateral flow tests are highly manufacturer-dependant. Low sensitivity increases the risk of false negative results and could result in unnecessary quarantine of test persons with developed antibodies. Low specificity increases the risk of false positive results and could lead to false assumptions of immunity. Carefully selected serological POC tests for sars-cov-2 can be used in large scale testing but should only be used by licensed medical staff able to understand their limitations and interpret the results.", "doi": null, "pmid": "32463475", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "20078"}], "notes": [], "created": "2020-11-11T07:18:07.394Z", "modified": "2021-01-17T08:19:34.625Z"}, {"entity": "publication", "iuid": "69a038d2c6724972a73cb9af9a52933a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69a038d2c6724972a73cb9af9a52933a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69a038d2c6724972a73cb9af9a52933a"}}, "title": "Could SARS-CoV-2-Induced Hyperinflammation Magnify the Severity of Coronavirus Disease (CoViD-19) Leading to Acute Respiratory Distress Syndrome?", "authors": [{"family": "Girija", "given": "A S Smiline", "initials": "ASS"}, {"family": "Shankar", "given": "Esaki M", "initials": "EM"}, {"family": "Larsson", "given": "Marie", "initials": "M"}], "type": "journal-article", "published": "2020-05-27", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "11", "issue": null, "pages": "1206", "issn-l": "1664-3224"}, "abstract": null, "doi": "10.3389/fimmu.2020.01206", "pmid": "32574269", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7267050"}], "notes": [], "created": "2020-12-08T16:20:21.680Z", "modified": "2021-12-06T13:19:34.348Z"}, {"entity": "publication", "iuid": "c1f61053726a446fa7eafc9b35b98a00", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1f61053726a446fa7eafc9b35b98a00.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1f61053726a446fa7eafc9b35b98a00"}}, "title": "Early Phylogenetic Diversification of SARS-CoV-2: Determination of Variants and the Effect on Epidemiology, Immunology, and Diagnostics", "authors": [{"family": "Kaden", "given": "Rene", "initials": "R", "orcid": "0000-0002-2111-9751", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2be6374ef0bf4ba39e5f5dbbb059747f.json"}}], "type": "journal-article", "published": "2020-05-26", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "9", "issue": "6", "pages": "1615", "issn-l": "2077-0383"}, "abstract": "The phylogenetic clustering of 95 SARS-CoV-2 sequences from the first 3 months of the pandemic reveals insights into the early evolution of the virus and gives first indications of how the variants are globally distributed. Variants might become a challenge in terms of diagnostics, immunology, and effectiveness of drugs. All available whole genome sequence data from the NCBI database (March 16, 2020) were phylogenetically analyzed, and gene prediction as well as analysis of selected variants were performed. Antigenic regions and the secondary protein structure were predicted for selected variants. While some clusters are presenting the same variant with 100% identical bases, other SARS-CoV-2 lineages show a beginning diversification and phylogenetic clustering due to base substitutions and deletions in the genomes. First molecular epidemiological investigations are possible with the results by adding metadata as travelling history to the presented data. The advantage of variants in source tracing can be a challenge in terms of virulence, immune response, and immunological memory. Variants of viruses often show differences in virulence or antigenicity. This must also be considered in decisions like herd immunity. Diagnostic methods might not work if the variations or deletions are in target regions for the detection of the pathogen. One base substitution was detected in a primer binding site.", "doi": "10.3390/jcm9061615", "pmid": "32466577", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "jcm9061615"}, {"db": "pmc", "key": "PMC7356205"}], "notes": [], "created": "2020-11-19T14:22:24.295Z", "modified": "2021-12-06T13:19:14.235Z"}, {"entity": "publication", "iuid": "135a6c58b8464dc2a03b65a276926648", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/135a6c58b8464dc2a03b65a276926648.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/135a6c58b8464dc2a03b65a276926648"}}, "title": "Environmental impact of the COVID-19 pandemic - a lesson for the future.", "authors": [{"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME", "orcid": "0000-0002-1056-4761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58d2f06f64154a2f9b5b22ffbb7518a3.json"}}, {"family": "Young", "given": "Sean G", "initials": "SG", "orcid": "0000-0002-0054-0627", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47701de524284532ba5e23aac25c1c6e.json"}}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD", "orcid": "0000-0002-7075-1059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4c50079915c44d39c996741c6156bfa.json"}}], "type": "editorial", "published": "2020-05-25", "journal": {"title": "Infect Ecol Epidemiol", "issn": "2000-8686", "issn-l": "2000-8686", "volume": "10", "issue": "1", "pages": "1768023"}, "abstract": "The environment is an integral component of human and animal health. COVID-19 is a global health challenge in the twenty-first century. The emergence of SARS-CoV-2 in Wuhan, China in December 2019, and its spread to regional countries and nowadays affecting more than 210 countries worldwide represents the first pandemic in history to be caused by a coronavirus. The COVID-19 pandemic has huge impacts on most aspects of human activities, as well as on the economy and health care systems. Lock-downs, quarantines and border closures in the wake of the pandemic have led to reductions in air pollution through decreased travel and production. These positive environmental effects are likely mostly temporary, but may serve as an example that changes in our way of life can have prompt positive effects for the environment and demonstrate the usefulness of travel-reducing measures such as teleconferencing. Thus, acknowledging that COVID-19 is first and foremost a global disaster, the pandemic may inspire to future behavioral changes with positive environmental effects.", "doi": "10.1080/20008686.2020.1768023", "pmid": "32922688", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "1768023"}, {"db": "pmc", "key": "PMC7448928"}], "notes": [], "created": "2020-11-22T09:32:53.923Z", "modified": "2021-12-06T13:18:56.009Z"}, {"entity": "publication", "iuid": "085268aa10e74516b1448ef2d74d1975", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/085268aa10e74516b1448ef2d74d1975.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/085268aa10e74516b1448ef2d74d1975"}}, "title": "Clinical and daily respiratory care and clinical trials within the COVID-19 era.", "authors": [{"family": "Diamant", "given": "Zuzana", "initials": "Z", "orcid": "0000-0003-0133-0100", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09c10bc9b15d4e8e80bfd0b11766bb58.json"}}, {"family": "Backer", "given": "Vibeke", "initials": "V", "orcid": "0000-0002-7806-7219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/559002d5b8384167b98a692e0a26a30f.json"}}, {"family": "Bjermer", "given": "Leif", "initials": "L", "orcid": "0000-0002-3441-8099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00285adfb31749e9a0c62eaa99b0b373.json"}}], "type": "editorial", "published": "2020-05-25", "journal": {"title": "Eur Clin Respir J", "issn": "2001-8525", "issn-l": null, "volume": "7", "issue": "1", "pages": "1766817"}, "abstract": "Editorial", "doi": "10.1080/20018525.2020.1766817", "pmid": "32922694", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "1766817"}, {"db": "pmc", "key": "PMC7448908"}], "notes": [], "created": "2020-12-03T15:48:16.477Z", "modified": "2021-12-06T13:18:38.752Z"}, {"entity": "publication", "iuid": "3f3785befa6c48f79fd5365680857182", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f3785befa6c48f79fd5365680857182.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f3785befa6c48f79fd5365680857182"}}, "title": "Gambling During the COVID-19 Crisis - A Cause for Concern.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "Fern\u00e1ndez-Aranda", "given": "Fernando", "initials": "F"}, {"family": "Mench\u00f3n", "given": "Jose M", "initials": "JM"}, {"family": "Potenza", "given": "Marc N", "initials": "MN"}, {"family": "Jim\u00e9nez-Murcia", "given": "Susana", "initials": "S"}], "type": "journal article", "published": "2020-05-21", "journal": {"title": "J Addict Med", "issn": "1935-3227", "volume": "14", "issue": "4", "pages": "e10-e12", "issn-l": null}, "abstract": ": The COVID-19 pandemic has the potential to worsen mental health problems in the general population, including increasing engagement in addictive behaviors. Here, we describe observations suggesting that the current crisis and its sequelae may worsen problem gambling. The current pandemic may impact financial and psychological well-being due to social isolation during spatial distancing, and these stressors in conjunction with substantial changes in gambling markets (land-based, online) during the pandemic may significantly influence gambling behaviors. This situation calls for rapid research initiatives in this area and preventive and regulatory measures by multiple stakeholders.", "doi": "10.1097/ADM.0000000000000690", "pmid": "32433365", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7273946"}], "notes": [], "created": "2020-12-09T11:37:03.546Z", "modified": "2021-12-06T13:17:38.631Z"}, {"entity": "publication", "iuid": "9c189a14da4c4d81a9fdfe210ce73acc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9c189a14da4c4d81a9fdfe210ce73acc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9c189a14da4c4d81a9fdfe210ce73acc"}}, "title": "Chemical Functionalization of 2D Materials", "authors": [{"family": "Mart\u00edn", "given": "Nazario", "initials": "N"}, {"family": "Tagmatarchis", "given": "Nikos", "initials": "N", "orcid": "0000-0001-7590-4635", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68a0b82ac2764eb1951d727f8ec53c51.json"}}, {"family": "Wang", "given": "Qing Hua", "initials": "QH", "orcid": "0000-0002-7982-7275", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8777f9f0f45646309baebeddf649856c.json"}}, {"family": "Zhang", "given": "Xiaoyan", "initials": "X", "orcid": "0000-0002-5469-8630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09b21da8cac141c29584498d44511889.json"}}], "type": "journal-article", "published": "2020-05-20", "journal": {"title": "Chem. Eur. J.", "issn": "0947-6539", "volume": "26", "issue": "29", "pages": "6292-6295", "issn-l": null}, "abstract": "This Special Issue of Chemistry-A European Journal is dedicated to the Chemical Functionalization of 2D Materials, and features some great contributions from experts in the field of 2D materials. This issue was originally assembled to support the Symposium G \"Chemical Functionalization of 2D Materials\" at the European Materials Research Society (E-MRS) 2020 Spring Meeting, which was originally scheduled to be held in Strasbourg, France, from May 25th to 29th, 2020. Although the E-MRS 2020 Spring Meeting has been cancelled due to the COVID-19 outbreak, the publication of this Special Issue has proceeded and has become even more important as the contributors discuss diverse and timely research themes related to 2D materials. In this Editorial, a brief overview of the different types of 2D materials is given, together with the chemical functionalization schemes that can be applied to them to achieve new properties as well as enable improved performance in applications. Some of the articles featured in this Special Issue are also highlighted, with the hope that they will inspire readers and further advance the field.", "doi": "10.1002/chem.202001304", "pmid": "32432399", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-09T11:38:10.781Z", "modified": "2021-12-06T13:16:27.356Z"}, {"entity": "publication", "iuid": "0a042c1b6ea14982811ebbf1d8386f35", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a042c1b6ea14982811ebbf1d8386f35.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a042c1b6ea14982811ebbf1d8386f35"}}, "title": "The pandemic of social media panic travels faster than the COVID-19 outbreak", "authors": [{"family": "Depoux", "given": "Anneliese", "initials": "A"}, {"family": "Martin", "given": "Sam", "initials": "S"}, {"family": "Karafillakis", "given": "Emilie", "initials": "E"}, {"family": "Preet", "given": "Raman", "initials": "R"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Larson", "given": "Heidi", "initials": "H"}], "type": "journal-article", "published": "2020-05-18", "journal": {"title": "J Travel Med", "issn": "1708-8305", "volume": "27", "issue": "3", "issn-l": null}, "abstract": null, "doi": "10.1093/jtm/taaa031", "pmid": "32125413", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5775501"}, {"db": "pmc", "key": "PMC7107516"}], "notes": [], "created": "2020-12-08T06:51:36.786Z", "modified": "2021-12-06T13:15:04.146Z"}, {"entity": "publication", "iuid": "6b6f0a046e184dc19d670a98b5567b07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b6f0a046e184dc19d670a98b5567b07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b6f0a046e184dc19d670a98b5567b07"}}, "title": "High population densities catalyse the spread of COVID-19", "authors": [{"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}, {"family": "Sj\u00f6din", "given": "Henrik", "initials": "H"}], "type": "journal-article", "published": "2020-05-18", "journal": {"title": "J Travel Med", "issn": "1708-8305", "volume": "27", "issue": "3", "issn-l": null}, "abstract": null, "doi": "10.1093/jtm/taaa038", "pmid": "32227186", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5807719"}, {"db": "pmc", "key": "PMC7184409"}], "notes": [], "created": "2020-12-09T11:47:10.998Z", "modified": "2021-12-06T13:14:39.528Z"}, {"entity": "publication", "iuid": "3a86650407624b3db05844404767e6c6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a86650407624b3db05844404767e6c6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a86650407624b3db05844404767e6c6"}}, "title": "COVID-19 outbreak on the Diamond Princess cruise ship: estimating the epidemic potential and effectiveness of public health countermeasures", "authors": [{"family": "Rockl\u00f6v", "given": "J", "initials": "J"}, {"family": "Sj\u00f6din", "given": "H", "initials": "H"}, {"family": "Wilder-Smith", "given": "A", "initials": "A"}], "type": "journal-article", "published": "2020-05-18", "journal": {"title": "J Travel Med", "issn": "1708-8305", "issn-l": null, "volume": "27", "issue": "3", "pages": null}, "abstract": "Cruise ships carry a large number of people in confined spaces with relative homogeneous mixing. On 3 February, 2020, an outbreak of COVID-19 on cruise ship Diamond Princess was reported with 10 initial cases, following an index case on board around 21-25th January. By 4th February, public health measures such as removal and isolation of ill passengers and quarantine of non-ill passengers were implemented. By 20th February, 619 of 3700 passengers and crew (17%) were tested positive.\n\nWe estimated the basic reproduction number from the initial period of the outbreak using SEIR models. We calibrated the models with transient functions of countermeasures to incidence data. We additionally estimated a counterfactual scenario in absence of countermeasures, and established a model stratified by crew and guests to study the impact of differential contact rates among the groups. We also compared scenarios of an earlier versus later evacuation of the ship.\n\nThe basic reproduction rate was initially 4 times higher on-board compared to the ${R}_0$ in the epicentre in Wuhan, but the countermeasures lowered it substantially. Based on the modeled initial ${R}_0$ of 14.8, we estimated that without any interventions within the time period of 21 January to 19 February, 2920 out of the 3700 (79%) would have been infected. Isolation and quarantine therefore prevented 2307 cases, and lowered the ${R}_0$ to 1.78. We showed that an early evacuation of all passengers on 3 February would have been associated with 76 infected persons in their incubation time.\n\nThe cruise ship conditions clearly amplified an already highly transmissible disease. The public health measures prevented more than 2000 additional cases compared to no interventions. However, evacuating all passengers and crew early on in the outbreak would have prevented many more passengers and crew from infection.", "doi": "10.1093/jtm/taaa030", "pmid": "32109273", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "5766334"}, {"db": "pmc", "key": "PMC7107563"}], "notes": [], "created": "2020-12-08T06:57:54.802Z", "modified": "2021-12-06T13:14:19.397Z"}, {"entity": "publication", "iuid": "9fc6eb922a5a4c6db0605957f1abc618", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9fc6eb922a5a4c6db0605957f1abc618.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9fc6eb922a5a4c6db0605957f1abc618"}}, "title": "Esophageal oncologic surgery in SARS-CoV-2 (COVID-19) emergency", "authors": [{"family": "Barbieri", "given": "Lavinia", "initials": "L"}, {"family": "Talavera Urquijo", "given": "Eider", "initials": "E", "orcid": "0000-0002-4793-5378", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db65329d4f1f487fa3afd522549e7430.json"}}, {"family": "Parise", "given": "Paolo", "initials": "P"}, {"family": "Nilsson", "given": "Magnus", "initials": "M"}, {"family": "Reynolds", "given": "John V", "initials": "JV"}, {"family": "Rosati", "given": "Riccardo", "initials": "R"}], "type": "journal-article", "published": "2020-05-15", "journal": {"title": "Dis Esophagus", "issn": "1442-2050", "volume": "33", "issue": "5", "pages": null, "issn-l": "1120-8694"}, "abstract": "Guidelines", "doi": "10.1093/dote/doaa028", "pmid": "32322892", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5823899"}, {"db": "pmc", "key": "PMC7188144"}], "notes": [], "created": "2020-11-23T11:45:36.075Z", "modified": "2021-12-06T13:13:34.720Z"}, {"entity": "publication", "iuid": "c9ed13bb0adf4357acdc4ce11d04ed45", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9ed13bb0adf4357acdc4ce11d04ed45.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9ed13bb0adf4357acdc4ce11d04ed45"}}, "title": "Deubiquitinating Enzymes in Coronaviruses and Possible Therapeutic Opportunities for COVID-19", "authors": [{"family": "Clemente", "given": "Valentino", "initials": "V"}, {"family": "D\u2019Arcy", "given": "Padraig", "initials": "P"}, {"family": "Bazzaro", "given": "Martina", "initials": "M"}], "type": "journal-article", "published": "2020-05-15", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "21", "issue": "10", "pages": "3492", "issn-l": null}, "abstract": "Following the outbreak of novel severe acute respiratory syndrome (SARS)-coronavirus (CoV)2, the majority of nations are struggling with countermeasures to fight infection, prevent spread and improve patient survival. Considering that the pandemic is a recent event, no large clinical trials have been possible and since coronavirus specific drug are not yet available, there is no strong consensus on how to treat the coronavirus disease 2019 (COVID-19) associated viral pneumonia. Coronaviruses code for an important multifunctional enzyme named papain-like protease (PLP), that has many roles in pathogenesis. First, PLP is one of the two viral cysteine proteases, along with 3-chymotripsin-like protease, that is responsible for the production of the replicase proteins required for viral replication. Second, its intrinsic deubiquitinating and deISGylating activities serve to antagonize the host's immune response that would otherwise hinder infection. Both deubiquitinating and deISGylating functions involve the removal of the small regulatory polypeptides, ubiquitin and ISG15, respectively, from target proteins. Ubiquitin modifications can regulate the innate immune response by affecting regulatory proteins, either by altering their stability via the ubiquitin proteasome pathway or by directly regulating their activity. ISG15 is a ubiquitin-like modifier with pleiotropic effects, typically expressed during the host cell immune response. PLP inhibitors have been evaluated during past coronavirus epidemics, and have showed promising results as an antiviral therapy in vitro. In this review, we recapitulate the roles of PLPs in coronavirus infections, report a list of PLP inhibitors and suggest possible therapeutic strategies for COVID-19 treatment, using both clinical and preclinical drugs.", "doi": "10.3390/ijms21103492", "pmid": "32429099", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijms21103492"}, {"db": "pmc", "key": "PMC7278987"}], "notes": [], "created": "2020-11-30T09:04:50.366Z", "modified": "2021-12-06T13:13:11.678Z"}, {"entity": "publication", "iuid": "13a9b64f789f4868a0c2bbb0b75fe84c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13a9b64f789f4868a0c2bbb0b75fe84c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13a9b64f789f4868a0c2bbb0b75fe84c"}}, "title": "COVID-19-Related Suicides in Bangladesh Due to Lockdown and Economic Factors: Case Study Evidence from Media Reports.", "authors": [{"family": "Bhuiyan", "given": "A K M Israfil", "initials": "AKMI"}, {"family": "Sakib", "given": "Najmuj", "initials": "N"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA"}], "type": "journal article", "published": "2020-05-15", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "volume": null, "issue": null, "pages": "1-6", "issn-l": null}, "abstract": null, "doi": "10.1007/s11469-020-00307-y", "pmid": "32427168", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "307"}, {"db": "pmc", "key": "PMC7228428"}], "notes": [], "created": "2020-12-09T11:40:51.584Z", "modified": "2021-12-06T13:12:52.761Z"}, {"entity": "publication", "iuid": "5669972f04844d0c8d2663e7733278b7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5669972f04844d0c8d2663e7733278b7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5669972f04844d0c8d2663e7733278b7"}}, "title": "Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2.", "authors": [{"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Kwon", "given": "Hyesoo", "initials": "H"}, {"family": "Prado", "given": "Patricia", "initials": "P"}, {"family": "Hagelkr\u00fcys", "given": "Astrid", "initials": "A"}, {"family": "Wimmer", "given": "Reiner A", "initials": "RA"}, {"family": "Stahl", "given": "Martin", "initials": "M"}, {"family": "Leopoldi", "given": "Alexandra", "initials": "A"}, {"family": "Garreta", "given": "Elena", "initials": "E"}, {"family": "Hurtado Del Pozo", "given": "Carmen", "initials": "C"}, {"family": "Prosper", "given": "Felipe", "initials": "F"}, {"family": "Romero", "given": "Juan Pablo", "initials": "JP"}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G"}, {"family": "Zhang", "given": "Haibo", "initials": "H"}, {"family": "Slutsky", "given": "Arthur S", "initials": "AS"}, {"family": "Conder", "given": "Ryan", "initials": "R"}, {"family": "Montserrat", "given": "Nuria", "initials": "N"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}], "type": "journal article", "published": "2020-05-14", "journal": {"title": "Cell", "issn": "1097-4172", "issn-l": "0092-8674", "volume": "181", "issue": "4", "pages": "905-913.e7"}, "abstract": "We have previously provided the first genetic evidence that angiotensin converting enzyme 2 (ACE2) is the critical receptor for severe acute respiratory syndrome coronavirus (SARS-CoV), and ACE2 protects the lung from injury, providing a molecular explanation for the severe lung failure and death due to SARS-CoV infections. ACE2 has now also been identified as a key receptor for SARS-CoV-2 infections, and it has been proposed that inhibiting this interaction might be used in treating patients with COVID-19. However, it is not known whether human recombinant soluble ACE2 (hrsACE2) blocks growth of SARS-CoV-2. Here, we show that clinical grade hrsACE2 reduced SARS-CoV-2 recovery from Vero cells by a factor of 1,000-5,000. An equivalent mouse rsACE2 had no effect. We also show that SARS-CoV-2 can directly infect engineered human blood vessel organoids and human kidney organoids, which can be inhibited by hrsACE2. These data demonstrate that hrsACE2 can significantly block early stages of SARS-CoV-2 infections.", "doi": "10.1016/j.cell.2020.04.004", "pmid": "32333836", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: H2020": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0092-8674(20)30399-8"}, {"db": "pmc", "key": "PMC7181998"}], "notes": [], "created": "2020-12-09T14:57:55.780Z", "modified": "2021-12-06T13:12:24.868Z"}, {"entity": "publication", "iuid": "2ce4cebb6df144ffae6ee014ab7b79a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ce4cebb6df144ffae6ee014ab7b79a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ce4cebb6df144ffae6ee014ab7b79a6"}}, "title": "EAPCI Position Statement on Invasive Management of Acute Coronary Syndromes during the COVID-19 pandemic.", "authors": [{"family": "Chieffo", "given": "Alaide", "initials": "A"}, {"family": "Stefanini", "given": "Giulio G", "initials": "GG"}, {"family": "Price", "given": "Susanna", "initials": "S"}, {"family": "Barbato", "given": "Emanuele", "initials": "E"}, {"family": "Tarantini", "given": "Giuseppe", "initials": "G"}, {"family": "Karam", "given": "Nicole", "initials": "N"}, {"family": "Moreno", "given": "Raul", "initials": "R"}, {"family": "Buchanan", "given": "Gill Louise", "initials": "GL"}, {"family": "Gilard", "given": "Martine", "initials": "M"}, {"family": "Halvorsen", "given": "Sigrun", "initials": "S"}, {"family": "Huber", "given": "Kurt", "initials": "K"}, {"family": "James", "given": "Stefan", "initials": "S"}, {"family": "Neumann", "given": "Franz-Josef", "initials": "FJ"}, {"family": "M\u00f6llmann", "given": "Helge", "initials": "H"}, {"family": "Roffi", "given": "Marco", "initials": "M"}, {"family": "Tavazzi", "given": "Guido", "initials": "G"}, {"family": "Mauri Ferr\u00e9", "given": "Josepa", "initials": "J"}, {"family": "Windecker", "given": "Stephan", "initials": "S"}, {"family": "Dudek", "given": "Dariusz", "initials": "D"}, {"family": "Baumbach", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2020-05-14", "journal": {"title": "Eur Heart J", "issn": "1522-9645", "volume": "41", "issue": "19", "pages": "1839-1851", "issn-l": "0195-668X"}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic poses an unprecedented challenge to healthcare worldwide. The infection can be life threatening and require intensive care treatment. The transmission of the disease poses a risk to both patients and healthcare workers. The number of patients requiring hospital admission and intensive care may overwhelm health systems and negatively affect standard care for patients presenting with conditions needing emergency interventions. This position statements aims to assist cardiologists in the invasive management of acute coronary syndrome (ACS) patients in the context of the COVID-19 pandemic. To that end, we assembled a panel of interventional cardiologists and acute cardiac care specialists appointed by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) and from the Acute Cardiovascular Care Association (ACVC) and included the experience from the first and worst affected areas in Europe. Modified diagnostic and treatment algorithms are proposed to adapt evidence-based protocols for this unprecedented challenge. Various clinical scenarios, as well as management algorithms for patients with a diagnosed or suspected COVID-19 infection, presenting with ST- and non-ST-segment elevation ACS are described. In addition, we address the need for re-organization of ACS networks, with redistribution of hub and spoke hospitals, as well as for in-hospital reorganization of emergency rooms and cardiac units, with examples coming from multiple European countries. Furthermore, we provide a guidance to reorganization of catheterization laboratories and, importantly, measures for protection of healthcare providers involved with invasive procedures.", "doi": "10.1093/eurheartj/ehaa381", "pmid": "32405641", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5836093"}, {"db": "pmc", "key": "PMC7239193"}], "notes": [], "created": "2020-12-10T08:49:39.425Z", "modified": "2021-12-06T13:12:03.006Z"}, {"entity": "publication", "iuid": "bad2b8ef26c14d8ea4275d7fdce85d0b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bad2b8ef26c14d8ea4275d7fdce85d0b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bad2b8ef26c14d8ea4275d7fdce85d0b"}}, "title": "Recommendations for Physical Inactivity and Sedentary Behavior During the Coronavirus Disease (COVID-19) Pandemic.", "authors": [{"family": "Ricci", "given": "Fabrizio", "initials": "F"}, {"family": "Izzicupo", "given": "Pascal", "initials": "P"}, {"family": "Moscucci", "given": "Federica", "initials": "F"}, {"family": "Sciomer", "given": "Susanna", "initials": "S"}, {"family": "Maffei", "given": "Silvia", "initials": "S"}, {"family": "Di Baldassarre", "given": "Angela", "initials": "A"}, {"family": "Mattioli", "given": "Anna Vittoria", "initials": "AV"}, {"family": "Gallina", "given": "Sabina", "initials": "S"}], "type": "journal article", "published": "2020-05-12", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "199", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2020.00199", "pmid": "32574294", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7235318"}], "notes": [], "created": "2020-12-08T16:18:42.625Z", "modified": "2021-12-06T13:11:44.902Z"}, {"entity": "publication", "iuid": "42a9ec324c29452b9841ab1130a695bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/42a9ec324c29452b9841ab1130a695bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/42a9ec324c29452b9841ab1130a695bd"}}, "title": "Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 \u2013 implications for microvascular inflammation and hypercoagulopathy in COVID-19", "authors": [{"family": "He", "given": "Liqun", "initials": "L"}, {"family": "M\u00e4e", "given": "Maarja Andaloussi", "initials": "MA"}, {"family": "Muhl", "given": "Lars", "initials": "L"}, {"family": "Sun", "given": "Ying", "initials": "Y"}, {"family": "Pietil\u00e4", "given": "Riikka", "initials": "R"}, {"family": "Nahar", "given": "Khayrun", "initials": "K"}, {"family": "Li\u00e9banas", "given": "Elisa V\u00e1zquez", "initials": "EV"}, {"family": "Fagerlund", "given": "Malin Jonsson", "initials": "MJ"}, {"family": "Oldner", "given": "Anders", "initials": "A"}, {"family": "Liu", "given": "Jianping", "initials": "J"}, {"family": "Genov\u00e9", "given": "Guillem", "initials": "G"}, {"family": "Zhang", "given": "Lei", "initials": "L"}, {"family": "Xie", "given": "Yuan", "initials": "Y"}, {"family": "Leptidis", "given": "Stefanos", "initials": "S"}, {"family": "Mocci", "given": "Giuseppe", "initials": "G"}, {"family": "Stritt", "given": "Simon", "initials": "S"}, {"family": "Osman", "given": "Ahmed", "initials": "A"}, {"family": "Anisimov", "given": "Andrey", "initials": "A"}, {"family": "Hemanthakumar", "given": "Karthik Amudhala", "initials": "KA"}, {"family": "R\u00e4s\u00e4nen", "given": "Markus", "initials": "M"}, {"family": "Mirabeau", "given": "Olivier", "initials": "O"}, {"family": "Hansson", "given": "Emil", "initials": "E"}, {"family": "Bj\u00f6rkegren", "given": "Johan", "initials": "J"}, {"family": "Vanlandewijck", "given": "Michael", "initials": "M"}, {"family": "Blomgren", "given": "Klas", "initials": "K"}, {"family": "M\u00e4kinen", "given": "Taija", "initials": "T"}, {"family": "Peng", "given": "Xiao Rong", "initials": "XR"}, {"family": "Arnold", "given": "Thomas D", "initials": "TD"}, {"family": "Alitalo", "given": "Kari", "initials": "K"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Lendahl", "given": "Urban", "initials": "U"}, {"family": "Betsholtz", "given": "Christer", "initials": "C"}], "type": "posted-content", "published": "2020-05-12", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.05.11.088500", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-20T06:40:52.233Z", "modified": "2021-12-06T13:11:25.970Z"}, {"entity": "publication", "iuid": "614cd9f9b80d48699960dc262af705ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/614cd9f9b80d48699960dc262af705ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/614cd9f9b80d48699960dc262af705ff"}}, "title": "Coronavirus Disease 2019 Return to Work Guidance and Recommendations for Vestibular Clinicians", "authors": [{"family": "Rizk", "given": "Habib G", "initials": "HG"}, {"family": "Strange", "given": "Christine", "initials": "C"}, {"family": "Atallah", "given": "Stephanie", "initials": "S"}, {"family": "Massingale", "given": "Shelly", "initials": "S"}, {"family": "Clendaniel", "given": "Richard", "initials": "R"}], "type": "journal-article", "published": "2020-05-12", "journal": {"title": "Ear Hear", "issn": "1538-4667", "volume": "41", "issue": "4", "pages": "693-696", "issn-l": null}, "abstract": "As states begin issuing progressive deconfinement guidelines, hospitals and institutions are starting to reopen for elective procedures and consultations. Vestibular clinicians are opening their practices to evaluate, test, or treat patients with dizziness and balance problems. The following document, requested by the American Balance Society, collates the current information about the virus, including transmission from asymptomatic carriers, decontamination, and other safety protocols, and provides a return to work guidance for clinicians caring for this population of patients, promoting provider, patient, and staff safety.", "doi": "10.1097/aud.0000000000000903", "pmid": "32427744", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-09T11:39:58.568Z", "modified": "2021-12-06T13:16:51.259Z"}, {"entity": "publication", "iuid": "626155cf829443a982103aceb07bea87", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/626155cf829443a982103aceb07bea87.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/626155cf829443a982103aceb07bea87"}}, "title": "Psychometric Validation of the Bangla Fear of COVID-19 Scale: Confirmatory Factor Analysis and Rasch Analysis", "authors": [{"family": "Sakib", "given": "Najmuj", "initials": "N"}, {"family": "Bhuiyan", "given": "A K M Israfil", "initials": "AKMI"}, {"family": "Hossain", "given": "Sahadat", "initials": "S"}, {"family": "Al Mamun", "given": "Firoj", "initials": "F"}, {"family": "Hosen", "given": "Ismail", "initials": "I"}, {"family": "Abdullah", "given": "Abu Hasnat", "initials": "AH"}, {"family": "Sarker", "given": "Md Abedin", "initials": "MA"}, {"family": "Mohiuddin", "given": "Mohammad Sarif", "initials": "MS"}, {"family": "Rayhan", "given": "Istihak", "initials": "I"}, {"family": "Hossain", "given": "Moazzem", "initials": "M"}, {"family": "Sikder", "given": "Md Tajuddin", "initials": "MT"}, {"family": "Gozal", "given": "David", "initials": "D"}, {"family": "Muhit", "given": "Mohammad", "initials": "M"}, {"family": "Islam", "given": "S M Shariful", "initials": "SMS"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA", "orcid": "0000-0002-1728-8966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6e65a5a97154d159a63cc2ce3f1b7a8.json"}}], "type": "journal-article", "published": "2020-05-11", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "issn-l": null, "volume": null, "issue": null, "pages": "1-12"}, "abstract": "The recently developed Fear of COVID-19 Scale (FCV-19S) is a seven-item uni-dimensional scale that assesses the severity of fears of COVID-19. Given the rapid increase of COVID-19 cases in Bangladesh, we aimed to translate and validate the FCV-19S in Bangla. The forward-backward translation method was used to translate the English version of the questionnaire into Bangla. The reliability and validity properties of the Bangla FCV-19S were rigorously psychometrically evaluated (utilizing both confirmatory factor analysis and Rasch analysis) in relation to socio-demographic variables, national lockdown variables, and response to the Bangla Health Patient Questionnaire. The sample comprised 8550 Bangladeshi participants. The Cronbach \u03b1 value for the Bangla FCV-19S was 0.871 indicating very good internal reliability. The results of the confirmatory factor analysis showed that the uni-dimensional factor structure of the FCV-19S fitted well with the data. The FCV-19S was significantly correlated with the nine-item Bangla Patient Health Questionnaire (PHQ-90) (r = 0.406, p < 0.001). FCV-19S scores were significantly associated with higher worries concerning lockdown. Measurement invariance of the FCV-19S showed no differences with respect to age or gender. The Bangla version of FCV-19S is a valid and reliable tool with robust psychometric properties which will be useful for researchers carrying out studies among the Bangla speaking population in assessing the psychological impact of fear from COVID-19 infection during this pandemic.", "doi": "10.1007/s11469-020-00289-x", "pmid": "32395096", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "289"}, {"db": "pmc", "key": "PMC7213549"}], "notes": [], "created": "2020-12-10T08:40:21.782Z", "modified": "2021-12-06T13:11:04.811Z"}, {"entity": "publication", "iuid": "884f876e112344c6a4d186eb368a32be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/884f876e112344c6a4d186eb368a32be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/884f876e112344c6a4d186eb368a32be"}}, "title": "Interventions for treatment of COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING Project).", "authors": [{"family": "Juul", "given": "Sophie", "initials": "S", "orcid": "0000-0002-6171-2904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76a1c669d07f4d559ae43063bb008b68.json"}}, {"family": "Nielsen", "given": "Niklas", "initials": "N"}, {"family": "Bentzer", "given": "Peter", "initials": "P"}, {"family": "Veroniki", "given": "Areti Angeliki", "initials": "AA"}, {"family": "Thabane", "given": "Lehana", "initials": "L"}, {"family": "Linder", "given": "Adam", "initials": "A"}, {"family": "Klingenberg", "given": "Sarah", "initials": "S"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Jakobsen", "given": "Janus Christian", "initials": "JC"}], "type": "journal article", "published": "2020-05-09", "journal": {"title": "Syst Rev", "issn": "2046-4053", "volume": "9", "issue": "1", "pages": "108", "issn-l": null}, "abstract": "COVID-19 is a rapidly spreading virus infection that has quickly caused extensive burden to individual, families, countries, and the globe. No intervention has yet been proven effective for the treatment of COVID-19. Some randomized clinical trials assessing the effects of different drugs have been published, and more are currently underway. There is an urgent need for a living, dynamic systematic review that continuously evaluates the beneficial and harmful effects of all available interventions for COVID-19.\n\nWe will conduct a living systematic review based on searches of major medical databases (e.g., MEDLINE, EMBASE, CENTRAL) and clinical trial registries from their inception onwards to identify relevant randomized clinical trials. We will update the literature search once a week to continuously assess if new evidence is available. Two review authors will independently extract data and perform risk of bias assessment. We will include randomized clinical trials comparing any intervention for the treatment of COVID-19 (e.g., pharmacological interventions, fluid therapy, invasive or noninvasive ventilation, or similar interventions) with any comparator (e.g., an \"active\" comparator, standard care, placebo, no intervention, or \"active placebo\") for participants in all age groups with a diagnosis of COVID-19. Primary outcomes will be all-cause mortality and serious adverse events. Secondary outcomes will be admission to intensive care, mechanical ventilation, renal replacement therapy, quality of life, and non-serious adverse events. The living systematic review will include aggregate data meta-analyses, Trial Sequential Analyses, network meta-analysis, and individual patient data meta-analyses. Risk of bias will be assessed with domains, an eight-step procedure will be used to assess if the thresholds for clinical significance are crossed, and the certainty of the evidence will be assessed by Grading of Recommendations, Assessment, Development and Evaluations (GRADE).\n\nCOVID-19 has become a pandemic with substantial mortality. A living systematic review evaluating the beneficial and harmful effects of pharmacological and other interventions is urgently needed. This review will continuously inform best practice in treatment and clinical research of this highly prevalent disease.\n\nPROSPERO CRD42020178787.", "doi": "10.1186/s13643-020-01371-0", "pmid": "32386514", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13643-020-01371-0"}, {"db": "pmc", "key": "PMC7210799"}], "notes": [], "created": "2020-11-30T09:08:00.686Z", "modified": "2021-12-06T13:10:13.292Z"}, {"entity": "publication", "iuid": "0cafcc70a7c24a7ab4559b6faf5bba13", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0cafcc70a7c24a7ab4559b6faf5bba13.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0cafcc70a7c24a7ab4559b6faf5bba13"}}, "title": "Development and Potential Usefulness of the COVID-19 Ag Respi-Strip Diagnostic Assay in a Pandemic Context", "authors": [{"family": "Mertens", "given": "Pascal", "initials": "P"}, {"family": "De Vos", "given": "Nathalie", "initials": "N"}, {"family": "Martiny", "given": "Delphine", "initials": "D"}, {"family": "Jassoy", "given": "Christian", "initials": "C"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Cuypers", "given": "Lize", "initials": "L"}, {"family": "Van den Wijngaert", "given": "Sigi", "initials": "S"}, {"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Melin", "given": "Pierrette", "initials": "P"}, {"family": "Stoffels", "given": "Karolien", "initials": "K"}, {"family": "Yin", "given": "Nicolas", "initials": "N"}, {"family": "Mileto", "given": "Davide", "initials": "D"}, {"family": "Delaunoy", "given": "Sabrina", "initials": "S"}, {"family": "Magein", "given": "Henri", "initials": "H"}, {"family": "Lagrou", "given": "Katrien", "initials": "K"}, {"family": "Bouzet", "given": "Justine", "initials": "J"}, {"family": "Serrano", "given": "Gabriela", "initials": "G"}, {"family": "Wautier", "given": "Magali", "initials": "M"}, {"family": "Leclipteux", "given": "Thierry", "initials": "T"}, {"family": "Van Ranst", "given": "Marc", "initials": "M"}, {"family": "Vandenberg", "given": "Olivier", "initials": "O"}, {"family": null, "given": "", "initials": ""}], "type": "journal-article", "published": "2020-05-08", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "7", "issue": null, "pages": "225", "issn-l": null}, "abstract": "Introduction: COVID-19 Ag Respi-Strip, an immunochromatographic (ICT) assay for the rapid detection of SARS-CoV-2 antigen on nasopharyngeal specimen, has been developed to identify positive COVID-19 patients allowing prompt clinical and quarantine decisions. In this original research article, we describe the conception, the analytical and clinical performances as well as the risk management of implementing the COVID-19 Ag Respi-Strip in a diagnostic decision algorithm. Materials and Methods: Development of the COVID-19 Ag Respi-Strip resulted in a ready-to-use ICT assay based on a membrane technology with colloidal gold nanoparticles using monoclonal antibodies directed against the SARS-CoV and SARS-CoV-2 highly conserved nucleoprotein antigen. Four hundred observations were recorded for the analytical performance study and thirty tests were analyzed for the cross-reactivity study. The clinical performance study was performed in a retrospective multi-centric evaluation on aliquots of 328 nasopharyngeal samples. COVID-19 Ag Respi-Strip results were compared with qRT-PCR as golden standard for COVID-19 diagnostics. Results: In the analytical performance study, the reproducibility showed a between-observer disagreement of 1.7%, a robustness of 98%, an overall satisfying user friendliness and no cross-reactivity with other virus-infected nasopharyngeal samples. In the clinical performance study performed in three different clinical laboratories during the ascendant phase of the epidemiological curve, we found an overall sensitivity and specificity of 57.6 and 99.5%, respectively with an accuracy of 82.6%. The cut-off of the ICT was found at CT <22. User-friendliness analysis and risk management assessment through Ishikawa diagram demonstrate that COVID-19 Ag Respi-Strip may be implemented in clinical laboratories according to biosafety recommendations. Conclusion: The COVID-19 Ag Respi-Strip represents a promising rapid SARS-CoV-2 antigen assay for the first-line diagnosis of COVID-19 in 15 min at the peak of the pandemic. Its role in the proposed diagnostic algorithm is complementary to the currently-used molecular techniques.", "doi": "10.3389/fmed.2020.00225", "pmid": "32574326", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7227790"}], "notes": [], "created": "2020-12-08T16:17:00.223Z", "modified": "2021-12-06T13:09:54.471Z"}, {"entity": "publication", "iuid": "908ed23706424854b3d884aeef134258", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/908ed23706424854b3d884aeef134258.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/908ed23706424854b3d884aeef134258"}}, "title": "The Battle Against COVID-19 in Jordan: An Early Overview of the Jordanian Experience", "authors": [{"family": "Al-Tammemi", "given": "Ala'a B", "initials": "AB"}], "type": "journal-article", "published": "2020-05-07", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "188", "issn-l": "2296-2565"}, "abstract": "Since the initial spark of the COVID-19 outbreak in December 2019, which was later declared by the World Health Organization (WHO) to be a global pandemic, all affected countries are implementing various preventive and control measures to mitigate the spread of the disease. The newly emerging virus brings with it uncertainty-not only regarding its behavior and transmission dynamics but also regarding the current lack of approved antiviral therapy or vaccines-and this represents a major challenge for decision makers at various levels and sectors. This article aims to provide an early overview of the COVID-19 battle within the Jordanian context, including general reflections and conclusions on the value of collaborative efforts in crises management.", "doi": "10.3389/fpubh.2020.00188", "pmid": "32574291", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7220996"}], "notes": [], "created": "2020-12-08T16:19:43.270Z", "modified": "2021-12-06T13:09:24.624Z"}, {"entity": "publication", "iuid": "880034e9b5a34bad9a810847f9895f9a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/880034e9b5a34bad9a810847f9895f9a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/880034e9b5a34bad9a810847f9895f9a"}}, "title": "Management of COVID-19-Positive Pediatric Patients Undergoing Minimally Invasive Surgical Procedures: Systematic Review and Recommendations of the Board of European Society of Pediatric Endoscopic Surgeons", "authors": [{"family": "Pini Prato", "given": "Alessio", "initials": "A"}, {"family": "Conforti", "given": "Andrea", "initials": "A"}, {"family": "Almstrom", "given": "Markus", "initials": "M"}, {"family": "Van Gemert", "given": "Wim", "initials": "W"}, {"family": "Scuderi", "given": "Maria G", "initials": "MG"}, {"family": "Khen-Dunlop", "given": "Naziha", "initials": "N"}, {"family": "Draghici", "given": "Isabela", "initials": "I"}, {"family": "Mendoza-Sagaon", "given": "Mario", "initials": "M"}, {"family": "Gin\u00e9 Prades", "given": "Carlos", "initials": "C"}, {"family": "Chiarenza", "given": "Fabio", "initials": "F"}, {"family": "Steyaert", "given": "Henri", "initials": "H"}], "type": "journal-article", "published": "2020-05-07", "journal": {"title": "Front Pediatr", "issn": "2296-2360", "volume": "8", "issue": null, "pages": "259", "issn-l": "2296-2360"}, "abstract": "Introduction: Hospital response to the COVID-19 outbreak has involved the cancellation of elective, deferrable surgeries throughout Europe in order to ensure capacity for emergent surgery and a selection of elective but non-deferrable surgeries. The purpose of this document is to propose technical strategies to assist the pediatric surgeons to minimize the potential aerosolization of viral particles in COVID-19 patients undergoing urgent or emergent surgical treatment using laparoscopic approaches, based on the currently available literature. The situation and recommendations are subject to change with emerging information. Materials and Methods: The Scientific Committee and the Board of the European Society of Pediatric Endoscopic Surgeons gathered together in order to address the issue of minimally invasive surgery during this COVID-19 pandemic. A systematic search through PubMed, Embase, and World Wide Web of the terms \"COVID-19,\" \"Coronavirus,\" and \"SARS-CoV-2\" matched with \"pneumoperitoneum,\" \"laparoscopy,\" \"thoracoscopy,\" \"retroperitoneoscopy,\" and \"surgery\" was performed. Non-English language papers were excluded. A PRISMA report was performed. Criticalities were identified and a consensus was achieved over a number of key aspects. Results: We identified 121 documents. A total of 11 full-text documents were assessed to address all concerns related to the adoption of minimally invasive surgery. All aspect of pediatric minimally invasive surgery, including elective surgery, urgent surgery, laparoscopy, thoracoscopy, retroperitoneoscopy, and pneumoperitoneum creation and maintainance were extensively addressed through systematic review. A consensus regarding urgent laparoscopic procedures, setting and operation techniques was obtained within the Committee and the Board. Conclusions: The ESPES proposes the following recommendations in case minimally invasive surgery is needed in a COVID-19 positive pediatric patients: (1) consider conservative treatment whenever safely possible, (2) dedicate a theater, columns and reusable laparoscopic instrumentation to COVID-19 pediatric patients, (3) prefer disposable instrumentation and cables, (4) use low CO2 insufflation pressures, (5) use low power electrocautery, (6) prefer closed-systems CO2 insufflation and desufflation systems, and (7) avoid leaks through ports. These recommendations are subject to change with emerging information and might be amended in the near future.", "doi": "10.3389/fped.2020.00259", "pmid": "32550670", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7232605"}], "notes": [], "created": "2020-11-26T12:19:59.137Z", "modified": "2021-12-06T13:08:58.197Z"}, {"entity": "publication", "iuid": "86df86b0add04971b430d355b695172f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86df86b0add04971b430d355b695172f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86df86b0add04971b430d355b695172f"}}, "title": "Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?", "authors": [{"family": "Andersson", "given": "Ulf", "initials": "U", "orcid": "0000-0003-0316-3860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee9bbcb5111f446e99ff8b68c4027f5c.json"}}, {"family": "Ottestad", "given": "William", "initials": "W"}, {"family": "Tracey", "given": "Kevin J", "initials": "KJ"}], "type": "journal article", "published": "2020-05-07", "journal": {"title": "Mol Med", "issn": "1528-3658", "volume": "26", "issue": "1", "pages": "42", "issn-l": "1076-1551"}, "abstract": "The 2019 novel coronavirus disease (COVID-19) causes for unresolved reasons acute respiratory distress syndrome in vulnerable individuals. There is a need to identify key pathogenic molecules in COVID-19-associated inflammation attainable to target with existing therapeutic compounds. The endogenous damage-associated molecular pattern (DAMP) molecule HMGB1 initiates inflammation via two separate pathways. Disulfide-HMGB1 triggers TLR4 receptors generating pro-inflammatory cytokine release. Extracellular HMGB1, released from dying cells or secreted by activated innate immunity cells, forms complexes with extracellular DNA, RNA and other DAMP or pathogen-associated molecular (DAMP) molecules released after lytic cell death. These complexes are endocytosed via RAGE, constitutively expressed at high levels in the lungs only, and transported to the endolysosomal system, which is disrupted by HMGB1 at high concentrations. Danger molecules thus get access to cytosolic proinflammatory receptors instigating inflammasome activation. It is conceivable that extracellular SARS-CoV-2 RNA may reach the cellular cytosol via HMGB1-assisted transfer combined with lysosome leakage. Extracellular HMGB1 generally exists in vivo bound to other molecules, including PAMPs and DAMPs. It is plausible that these complexes are specifically removed in the lungs revealed by a 40% reduction of HMGB1 plasma levels in arterial versus venous blood. Abundant pulmonary RAGE expression enables endocytosis of danger molecules to be destroyed in the lysosomes at physiological HMGB1 levels, but causing detrimental inflammasome activation at high levels. Stress induces apoptosis in pulmonary endothelial cells from females but necrosis in cells from males.\n\nBased on these observations we propose extracellular HMGB1 to be considered as a therapeutic target for COVID-19.", "doi": "10.1186/s10020-020-00172-4", "pmid": "32380958", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s10020-020-00172-4"}, {"db": "pmc", "key": "PMC7203545"}], "notes": [], "created": "2020-11-25T07:30:42.009Z", "modified": "2021-12-06T13:08:39.901Z"}, {"entity": "publication", "iuid": "8f6f511b573945a1be8bb0f50b2f68ad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f6f511b573945a1be8bb0f50b2f68ad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f6f511b573945a1be8bb0f50b2f68ad"}}, "title": "COVID-19: a challenge for oncology services.", "authors": [{"family": "Routy", "given": "Bertrand", "initials": "B"}, {"family": "Derosa", "given": "Lisa", "initials": "L"}, {"family": "Zitvogel", "given": "Laurence", "initials": "L", "orcid": "0000-0003-1596-0998", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b10947c1a2b4884b3f502625a28c5e0.json"}}, {"family": "Kroemer", "given": "Guido", "initials": "G", "orcid": "0000-0002-9334-4405", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d17de2122d0429eaa48a733bf2ad28e.json"}}], "type": "editorial", "published": "2020-05-05", "journal": {"title": "Oncoimmunology", "issn": "2162-4011", "volume": "9", "issue": "1", "pages": "1760686", "issn-l": null}, "abstract": null, "doi": "10.1080/2162402X.2020.1760686", "pmid": "32923119", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "1760686"}, {"db": "pmc", "key": "PMC7458620"}], "notes": [], "created": "2020-12-03T15:47:32.730Z", "modified": "2021-12-06T13:07:47.749Z"}, {"entity": "publication", "iuid": "01fac03dcd13402b921d766ed13344f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01fac03dcd13402b921d766ed13344f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01fac03dcd13402b921d766ed13344f4"}}, "title": "Digesting the crisis: autophagy and coronaviruses.", "authors": [{"family": "Carmona-Gutierrez", "given": "Didac", "initials": "D"}, {"family": "Bauer", "given": "Maria A", "initials": "MA"}, {"family": "Zimmermann", "given": "Andreas", "initials": "A"}, {"family": "Kainz", "given": "Katharina", "initials": "K"}, {"family": "Hofer", "given": "Sebastian J", "initials": "SJ"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}, {"family": "Madeo", "given": "Frank", "initials": "F"}], "type": "journal article", "published": "2020-05-04", "journal": {"title": "Microb Cell", "issn": "2311-2638", "volume": "7", "issue": "5", "pages": "119-128", "issn-l": "2311-2638"}, "abstract": "Autophagy is a catabolic pathway with multifaceted roles in cellular homeostasis. This process is also involved in the antiviral response at multiple levels, including the direct elimination of intruding viruses (virophagy), the presentation of viral antigens, the fitness of immune cells, and the inhibition of excessive inflammatory reactions. In line with its central role in immunity, viruses have evolved mechanisms to interfere with or to evade the autophagic process, and in some cases, even to harness autophagy or constituents of the autophagic machinery for their replication. Given the devastating consequences of the current COVID-19 pandemic, the question arises whether manipulating autophagy might be an expedient approach to fight the novel coronavirus SARS-CoV-2. In this piece, we provide a short overview of the evidence linking autophagy to coronaviruses and discuss whether such links may provide actionable targets for therapeutic interventions.", "doi": "10.15698/mic2020.05.715", "pmid": "32391393", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "MIC0270E122"}, {"db": "pmc", "key": "PMC7199282"}], "notes": [], "created": "2020-11-25T07:58:17.099Z", "modified": "2021-12-06T13:06:40.272Z"}, {"entity": "publication", "iuid": "b405175e46c046df86d6925d657f3ed8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b405175e46c046df86d6925d657f3ed8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b405175e46c046df86d6925d657f3ed8"}}, "title": "A united statement of the global chiropractic research community against the pseudoscientific claim that chiropractic care boosts immunity.", "authors": [{"family": "C\u00f4t\u00e9", "given": "Pierre", "initials": "P"}, {"family": "Bussi\u00e8res", "given": "Andr\u00e9", "initials": "A"}, {"family": "Cassidy", "given": "J David", "initials": "JD"}, {"family": "Hartvigsen", "given": "Jan", "initials": "J"}, {"family": "Kawchuk", "given": "Greg N", "initials": "GN"}, {"family": "Leboeuf-Yde", "given": "Charlotte", "initials": "C"}, {"family": "Mior", "given": "Silvano", "initials": "S"}, {"family": "Schneider", "given": "Michael", "initials": "M"}, {"family": "140 signatories# call for an end to pseudoscientific claims on the effect of chiropractic care on immune function", "given": "", "initials": ""}], "type": "journal article", "published": "2020-05-04", "journal": {"title": "Chiropr Man Therap", "issn": "2045-709X", "volume": "28", "issue": "1", "pages": "21", "issn-l": "2045-709X"}, "abstract": "In the midst of the coronavirus pandemic, the International Chiropractors Association (ICA) posted reports claiming that chiropractic care can impact the immune system. These claims clash with recommendations from the World Health Organization and World Federation of Chiropractic. We discuss the scientific validity of the claims made in these ICA reports.\n\nWe reviewed the two reports posted by the ICA on their website on March 20 and March 28, 2020. We explored the method used to develop the claim that chiropractic adjustments impact the immune system and discuss the scientific merit of that claim. We provide a response to the ICA reports and explain why this claim lacks scientific credibility and is dangerous to the public. More than 150 researchers from 11 countries reviewed and endorsed our response.\n\nIn their reports, the ICA provided no valid clinical scientific evidence that chiropractic care can impact the immune system. We call on regulatory authorities and professional leaders to take robust political and regulatory action against those claiming that chiropractic adjustments have a clinical impact on the immune system.", "doi": "10.1186/s12998-020-00312-x", "pmid": "32366319", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12998-020-00312-x"}, {"db": "pmc", "key": "PMC7197358"}], "notes": [], "created": "2020-11-25T07:24:09.543Z", "modified": "2021-12-06T13:06:22.682Z"}, {"entity": "publication", "iuid": "5325440967464cc29a380ee219699347", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5325440967464cc29a380ee219699347.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5325440967464cc29a380ee219699347"}}, "title": "Preventing spread of SARS-CoV-2 and preparing for the COVID-19 outbreak in the surgical department: perspectives from two Scandinavian countries", "authors": [{"family": "Lindeman", "given": "Robbert Jan", "initials": "RJ"}, {"family": "Sund", "given": "Malin", "initials": "M"}, {"family": "L\u00f6fgren", "given": "Jenny", "initials": "J"}, {"family": "Basso", "given": "Trude", "initials": "T"}, {"family": "S\u00f8reide", "given": "Kjetil", "initials": "K", "orcid": "0000-0001-7594-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9c5655fc6aa437d91ed5cc2b4791543.json"}}], "type": "journal-article", "published": "2020-05-01", "journal": {"title": "J Surg Case Rep", "issn": "2042-8812", "issn-l": "2042-8812", "volume": "2020", "issue": "5", "pages": "rjaa131"}, "abstract": "A COVID-19 pandemic was declared on March 11 by the World Health Organization (WHO). The first cases of COVID-19 were confirmed on January 31 in Sweden and on February 26 in Norway. Despite being similar countries with universal healthcare systems, the governmental approaches to mitigation of the epidemic have varied considerably. Norway initiated a societal lockdown effective from March 12, the same day as the first confirmed death. Sweden has initiated a more laxed and gradual strategy based on the appeal for a strong personal sense of responsibility to mitigate the viral spread. In both countries, the first weeks of preparation has seen a strong reduction in elective surgery, with several implemented principles to mitigate SARS-CoV-2 spread and prepare for surgical care for COVID-19 diseases as needed. This invited leading article gives a brief overview of some of the early experiences of the outbreak in two Scandinavian countries.", "doi": "10.1093/jscr/rjaa131", "pmid": "32395226", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "rjaa131"}, {"db": "pmc", "key": "PMC7202331"}], "notes": [], "created": "2020-11-25T07:59:03.840Z", "modified": "2021-12-06T13:04:20.843Z"}, {"entity": "publication", "iuid": "4d4cde731a184da8be9ae3d417ecb902", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4d4cde731a184da8be9ae3d417ecb902.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4d4cde731a184da8be9ae3d417ecb902"}}, "title": "Dysregulation in mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells", "authors": [{"family": "Appelberg", "given": "Sofia", "initials": "S"}, {"family": "Gupta", "given": "Soham", "initials": "S"}, {"family": "Ambikan", "given": "Anoop T", "initials": "AT"}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "V\u00e9gv\u00e1ri", "given": "\u00c1kos", "initials": "\u00c1"}, {"family": "Akusj\u00e4rvi", "given": "Sara Svensson", "initials": "SS"}, {"family": "Benfeitas", "given": "Rui", "initials": "R"}, {"family": "Sperk", "given": "Maike", "initials": "M"}, {"family": "St\u00e5hlberg", "given": "Marie", "initials": "M"}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Singh", "given": "Kamal", "initials": "K"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "posted-content", "published": "2020-05-01", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.04.30.070383", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-14T14:58:17.708Z", "modified": "2021-12-06T13:06:02.092Z"}, {"entity": "publication", "iuid": "aef310ad68884b00ad09dff6ca327828", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aef310ad68884b00ad09dff6ca327828.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aef310ad68884b00ad09dff6ca327828"}}, "title": "What does COVID\u201019 distract us from? A migration studies perspective on the inequities of attention", "authors": [{"family": "Della Rosa", "given": "Asia", "initials": "A", "orcid": "0000-0002-2604-0284", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93497b0315174b4697d5b15e56cd656c.json"}}, {"family": "Goldstein", "given": "Asher", "initials": "A", "orcid": "0000-0003-4314-9596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52c678422cb34e36a9974fc180fa6b13.json"}}], "type": "journal-article", "published": "2020-05-00", "journal": {"title": "Soc Anthropol", "issn": "1469-8676", "volume": "28", "issue": "2", "pages": "257-259", "issn-l": null}, "abstract": null, "doi": "10.1111/1469-8676.12899", "pmid": "32836948", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "SOCA12899"}, {"db": "pmc", "key": "PMC7276791"}], "notes": [], "created": "2020-12-07T10:37:28.561Z", "modified": "2021-12-06T13:15:35.718Z"}, {"entity": "publication", "iuid": "fc4e079187234aeaa3ba585e6cbd4fd7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc4e079187234aeaa3ba585e6cbd4fd7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc4e079187234aeaa3ba585e6cbd4fd7"}}, "title": "The Need of Research Initiatives Amidst and After the Covid-19 Pandemic: A Message from the Editors of the EJVES", "authors": [{"family": "Bj\u00f6rck", "given": "Martin", "initials": "M"}, {"family": "Boyle", "given": "Jonathan R", "initials": "JR"}, {"family": "Dick", "given": "Florian", "initials": "F"}], "type": "journal-article", "published": "2020-05-00", "journal": {"title": "Eur J Vasc Endovasc Surg", "issn": "1078-5884", "volume": "59", "issue": "5", "pages": "695-696", "issn-l": null}, "abstract": "Editorial", "doi": "10.1016/j.ejvs.2020.04.002", "pmid": "32303451", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1078-5884(20)30324-5"}, {"db": "pmc", "key": "PMC7151378"}], "notes": [], "created": "2020-11-22T08:52:45.922Z", "modified": "2021-12-06T13:05:35.086Z"}, {"entity": "publication", "iuid": "0c478d1d514d4c4b9f631e9223d724b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c478d1d514d4c4b9f631e9223d724b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c478d1d514d4c4b9f631e9223d724b0"}}, "title": "Saliva testing for COVID-19?", "authors": [{"family": "Sapkota", "given": "D", "initials": "D"}, {"family": "Thapa", "given": "S B", "initials": "SB"}, {"family": "Hass\u00e9us", "given": "B", "initials": "B"}, {"family": "Jensen", "given": "J L", "initials": "JL"}], "type": "journal-article", "published": "2020-05-00", "journal": {"title": "Br Dent J", "issn": "1476-5373", "volume": "228", "issue": "9", "pages": "658-659", "issn-l": null}, "abstract": null, "doi": "10.1038/s41415-020-1594-7", "pmid": "32385433", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41415-020-1594-7"}], "notes": [], "created": "2020-12-10T07:41:02.939Z", "modified": "2021-12-06T13:05:14.408Z"}, {"entity": "publication", "iuid": "799fba058334420eb8a7605051fb1b71", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/799fba058334420eb8a7605051fb1b71.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/799fba058334420eb8a7605051fb1b71"}}, "title": "Protecting children in low-income and middle-income countries from COVID-19", "authors": [{"family": "Ahmed", "given": "Salahuddin", "initials": "S", "orcid": "0000-0001-6771-0638", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36afb59c938e4bc8bbcaf428373622c4.json"}}, {"family": "Mvalo", "given": "Tisungane", "initials": "T"}, {"family": "Akech", "given": "Samuel", "initials": "S"}, {"family": "Agweyu", "given": "Ambrose", "initials": "A"}, {"family": "Baker", "given": "Kevin", "initials": "K"}, {"family": "Bar-Zeev", "given": "Naor", "initials": "N"}, {"family": "Campbell", "given": "Harry", "initials": "H"}, {"family": "Checkley", "given": "William", "initials": "W"}, {"family": "Chisti", "given": "Mohammod Jobayer", "initials": "MJ"}, {"family": "Colbourn", "given": "Tim", "initials": "T", "orcid": "0000-0002-6917-6552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2cccce75e4b4602ab197604cb444a0a.json"}}, {"family": "Cunningham", "given": "Steve", "initials": "S"}, {"family": "Duke", "given": "Trevor", "initials": "T"}, {"family": "English", "given": "Mike", "initials": "M", "orcid": "0000-0002-7427-0826", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d680cdafc8854a619f1919652dd16aed.json"}}, {"family": "Falade", "given": "Adegoke G", "initials": "AG"}, {"family": "Fancourt", "given": "Nicholas SS", "initials": "NS", "orcid": "0000-0002-1772-9960", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5c4d94e20e74d02a6ee3f4287e0d588.json"}}, {"family": "Ginsburg", "given": "Amy S", "initials": "AS"}, {"family": "Graham", "given": "Hamish R", "initials": "HR", "orcid": "0000-0003-2461-0463", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d2d23d0b7dc40f3979a4342d3898649.json"}}, {"family": "Gray", "given": "Diane M", "initials": "DM"}, {"family": "Gupta", "given": "Madhu", "initials": "M"}, {"family": "Hammitt", "given": "Laura", "initials": "L"}, {"family": "Hesseling", "given": "Anneke C", "initials": "AC"}, {"family": "Hooli", "given": "Shubhada", "initials": "S", "orcid": "0000-0003-4596-448X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20d63548cf4340a2a8e3d092113580d7.json"}}, {"family": "Johnson", "given": "Abdul Wahab BR", "initials": "AWB"}, {"family": "King", "given": "Carina", "initials": "C"}, {"family": "Kirby", "given": "Miles A", "initials": "MA"}, {"family": "Lanata", "given": "Claudio F", "initials": "CF"}, {"family": "Lufesi", "given": "Norman", "initials": "N"}, {"family": "Mackenzie", "given": "Grant A", "initials": "GA"}, {"family": "McCracken", "given": "John P", "initials": "JP"}, {"family": "Moschovis", "given": "Peter P", "initials": "PP", "orcid": "0000-0002-9664-5959", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5df313713eda423196bc8f01c3cccd6a.json"}}, {"family": "Nair", "given": "Harish", "initials": "H"}, {"family": "Oviawe", "given": "Osawaru", "initials": "O"}, {"family": "Pomat", "given": "William S", "initials": "WS"}, {"family": "Santosham", "given": "Mathuram", "initials": "M"}, {"family": "Seddon", "given": "James A", "initials": "JA"}, {"family": "Thahane", "given": "Lineo Keneuoe", "initials": "LK"}, {"family": "Wahl", "given": "Brian", "initials": "B", "orcid": "0000-0002-0037-7364", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a1b355e68f949a3964fac2381982327.json"}}, {"family": "Van der Zalm", "given": "Marieke", "initials": "M"}, {"family": "Verwey", "given": "Charl", "initials": "C"}, {"family": "Yoshida", "given": "Lay Myint", "initials": "LM"}, {"family": "Zar", "given": "Heather J", "initials": "HJ"}, {"family": "Howie", "given": "Stephen RC", "initials": "SR"}, {"family": "McCollum", "given": "Eric D", "initials": "ED", "orcid": "0000-0002-1872-5566", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/95a0edabce86477287b3354ea4861a33.json"}}], "type": "journal-article", "published": "2020-05-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "5", "issue": "5", "pages": "e002844", "issn-l": "2059-7908"}, "abstract": "Editorial", "doi": "10.1136/bmjgh-2020-002844", "pmid": "32461228", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-002844"}, {"db": "pmc", "key": "PMC7254117"}], "notes": [], "created": "2020-11-25T09:21:02.315Z", "modified": "2021-12-06T13:04:54.117Z"}, {"entity": "publication", "iuid": "a25c8dcffb2040b787a0f1d3621f4dce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a25c8dcffb2040b787a0f1d3621f4dce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a25c8dcffb2040b787a0f1d3621f4dce"}}, "title": "Practice recommendations for lung cancer radiotherapy during the COVID-19 pandemic: An ESTRO-ASTRO consensus statement.", "authors": [{"family": "Guckenberger", "given": "Matthias", "initials": "M", "orcid": "0000-0002-7146-9071", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09684c7ae622448f99208130af9e282e.json"}}, {"family": "Belka", "given": "Claus", "initials": "C"}, {"family": "Bezjak", "given": "Andrea", "initials": "A"}, {"family": "Bradley", "given": "Jeffrey", "initials": "J"}, {"family": "Daly", "given": "Megan E", "initials": "ME", "orcid": "0000-0001-7308-6149", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc0b3418cf5d4e1897814f629298d06e.json"}}, {"family": "DeRuysscher", "given": "Dirk", "initials": "D"}, {"family": "Dziadziuszko", "given": "Rafal", "initials": "R", "orcid": "0000-0001-8080-9843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e81c6277a79c41bca7fa5d9a83bc4e6e.json"}}, {"family": "Faivre-Finn", "given": "Corinne", "initials": "C", "orcid": "0000-0001-5617-9781", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e12bb7f823e74c3bb7e16a73b04d594c.json"}}, {"family": "Flentje", "given": "Michael", "initials": "M"}, {"family": "Gore", "given": "Elizabeth", "initials": "E"}, {"family": "Higgins", "given": "Kristin A", "initials": "KA"}, {"family": "Iyengar", "given": "Puneeth", "initials": "P"}, {"family": "Kavanagh", "given": "Brian D", "initials": "BD", "orcid": "0000-0001-5579-1725", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7c5b8b6b8804b22896a1d2efcca9285.json"}}, {"family": "Kumar", "given": "Sameera", "initials": "S"}, {"family": "Le Pechoux", "given": "Cecile", "initials": "C"}, {"family": "Lievens", "given": "Yolande", "initials": "Y"}, {"family": "Lindberg", "given": "Karin", "initials": "K"}, {"family": "McDonald", "given": "Fiona", "initials": "F"}, {"family": "Ramella", "given": "Sara", "initials": "S"}, {"family": "Rengan", "given": "Ramesh", "initials": "R", "orcid": "0000-0001-5379-536X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6006bff18bfe4dd38cce342cf4008e28.json"}}, {"family": "Ricardi", "given": "Umberto", "initials": "U", "orcid": "0000-0003-4406-7621", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4592c02990ab440790e7391977331369.json"}}, {"family": "Rimner", "given": "Andreas", "initials": "A"}, {"family": "Rodrigues", "given": "George B", "initials": "GB"}, {"family": "Schild", "given": "Steven E", "initials": "SE"}, {"family": "Senan", "given": "Suresh", "initials": "S"}, {"family": "Simone", "given": "Charles B", "initials": "CB 2nd"}, {"family": "Slotman", "given": "Ben J", "initials": "BJ", "orcid": "0000-0002-9902-4592", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c53ea83c8d964c08b08ec6efe7d782cb.json"}}, {"family": "Stuschke", "given": "Martin", "initials": "M"}, {"family": "Videtic", "given": "Greg", "initials": "G"}, {"family": "Widder", "given": "Joachim", "initials": "J", "orcid": "0000-0002-9972-6690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12f78661cf184d809e1208fdb742cdbb.json"}}, {"family": "Yom", "given": "Sue S", "initials": "SS", "orcid": "0000-0002-0779-7476", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dcd04dd7ffd94ac79534245657af08ca.json"}}, {"family": "Palma", "given": "David", "initials": "D", "orcid": "0000-0002-9542-0627", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c33cf08374fb445887d22f67b62f1792.json"}}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "Radiother Oncol", "issn": "1879-0887", "volume": "146", "issue": null, "pages": "223-229", "issn-l": "0167-8140"}, "abstract": "The COVID-19 pandemic has caused radiotherapy resource pressures and led to increased risks for lung cancer patients and healthcare staff. An international group of experts in lung cancer radiotherapy established this practice recommendation pertaining to whether and how to adapt radiotherapy for lung cancer in the COVID-19 pandemic.\n\nFor this ESTRO & ASTRO endorsed project, 32 experts in lung cancer radiotherapy contributed to a modified Delphi consensus process. We assessed potential adaptations of radiotherapy in two pandemic scenarios. The first, an early pandemic scenario of risk mitigation, is characterized by an altered risk-benefit ratio of radiotherapy for lung cancer patients due to their increased susceptibility for severe COVID-19 infection, and minimization of patient travelling and exposure of radiotherapy staff. The second, a later pandemic scenario, is characterized by reduced radiotherapy resources requiring patient triage. Six common lung cancer cases were assessed for both scenarios: peripherally located stage I NSCLC, locally advanced NSCLC, postoperative radiotherapy after resection of pN2 NSCLC, thoracic radiotherapy and prophylactic cranial irradiation for limited stage SCLC and palliative thoracic radiotherapy for stage IV NSCLC.\n\nIn a risk-mitigation pandemic scenario, efforts should be made not to compromise the prognosis of lung cancer patients by departing from guideline-recommended radiotherapy practice. In that same scenario, postponement or interruption of radiotherapy treatment of COVID-19 positive patients is generally recommended to avoid exposure of cancer patients and staff to an increased risk of COVID-19 infection. In a severe pandemic scenario characterized by reduced resources, if patients must be triaged, important factors for triage include potential for cure, relative benefit of radiation, life expectancy, and performance status. Case-specific consensus recommendations regarding multimodality treatment strategies and fractionation of radiotherapy are provided.\n\nThis joint ESTRO-ASTRO practice recommendation established pragmatic and balanced consensus recommendations in common clinical scenarios of radiotherapy for lung cancer in order to address the challenges of the COVID-19 pandemic.", "doi": "10.1016/j.radonc.2020.04.001", "pmid": "32342863", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0167-8140(20)30182-1"}, {"db": "pmc", "key": "PMC7252074"}], "notes": [], "created": "2020-11-25T07:13:12.107Z", "modified": "2021-12-06T13:03:46.407Z"}, {"entity": "publication", "iuid": "d0ce868b1d99450081c6108a163f3209", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d0ce868b1d99450081c6108a163f3209.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d0ce868b1d99450081c6108a163f3209"}}, "title": "Managing COVID-19 in the oncology clinic and avoiding the distraction effect.", "authors": [{"family": "Cortiula", "given": "F", "initials": "F"}, {"family": "Pettke", "given": "A", "initials": "A"}, {"family": "Bartoletti", "given": "M", "initials": "M"}, {"family": "Puglisi", "given": "F", "initials": "F"}, {"family": "Helleday", "given": "T", "initials": "T"}], "type": "editorial", "published": "2020-05-00", "journal": {"title": "Annals of Oncology", "issn": "1569-8041", "volume": "31", "issue": "5", "pages": "553-555", "issn-l": "0923-7534"}, "abstract": null, "doi": "10.1016/j.annonc.2020.03.286", "pmid": "32201224", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0923-7534(20)36373-0"}, {"db": "pmc", "key": "PMC7174827"}], "notes": [], "created": "2020-11-04T13:17:26.873Z", "modified": "2021-12-06T13:03:18.096Z"}, {"entity": "publication", "iuid": "915fc7aead7f44f0b92cddf6e2657588", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/915fc7aead7f44f0b92cddf6e2657588.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/915fc7aead7f44f0b92cddf6e2657588"}}, "title": "Management of Advanced Therapies in Parkinson's Disease Patients in Times of Humanitarian Crisis: The COVID-19 Experience.", "authors": [{"family": "Fasano", "given": "Alfonso", "initials": "A"}, {"family": "Antonini", "given": "Angelo", "initials": "A"}, {"family": "Katzenschlager", "given": "Regina", "initials": "R"}, {"family": "Krack", "given": "Paul", "initials": "P"}, {"family": "Odin", "given": "Per", "initials": "P"}, {"family": "Evans", "given": "Andrew H", "initials": "AH"}, {"family": "Foltynie", "given": "Thomas", "initials": "T"}, {"family": "Volkmann", "given": "Jens", "initials": "J"}, {"family": "Merello", "given": "Marcelo", "initials": "M"}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "Mov Disord Clin Pract", "issn": "2330-1619", "volume": "7", "issue": "4", "pages": "361-372", "issn-l": null}, "abstract": "Although the COVID-19 pandemic is affecting a relatively small proportion of the global population, its effects have already reached everyone. The pandemic has the potential to differentially disadvantage chronically ill patients, including those with Parkinson's disease (PD). The first health care reaction has been to limit access to clinics and neurology wards to preserve fragile patients with PD from being infected. In some regions, the shortage of medical staff has also forced movement disorders neurologists to provide care for patients with COVID-19.\n\nTo share the experience of various movement disorder neurologists operating in different world regions and provide a common approach to patients with PD, with a focus on those already on advanced therapies, which may serve as guidance in the current pandemic and for emergency situations that we may face in the future.\n\nMost of us were unprepared to deal with this condition given that in many health care systems, telemedicine has been only marginally available or only limited to email or telephone contacts. In addition, to ensure sufficient access to intensive care unit beds, most elective procedures (including deep brain stimulation or the initiation of infusion therapies) have been postponed. We all hope there will soon be a time when we will return to more regular hospital schedules. However, we should consider this crisis as an opportunity to change our approach and encourage our hospitals and health care systems to facilitate the remote management of chronic neurological patients, including those with advanced PD.", "doi": "10.1002/mdc3.12965", "pmid": "32373652", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "MDC312965"}, {"db": "pmc", "key": "PMC7197306"}], "notes": [], "created": "2020-12-10T07:32:13.596Z", "modified": "2020-12-10T07:32:13.608Z"}, {"entity": "publication", "iuid": "6880115da67342c8aee2da2101ee00ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6880115da67342c8aee2da2101ee00ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6880115da67342c8aee2da2101ee00ee"}}, "title": "ISUOG Safety Committee Position Statement on safe performance of obstetric and gynecological scans and equipment cleaning in context of COVID-19.", "authors": [{"family": "Poon", "given": "L C", "initials": "LC"}, {"family": "Abramowicz", "given": "J S", "initials": "JS"}, {"family": "Dall'Asta", "given": "A", "initials": "A"}, {"family": "Sande", "given": "R", "initials": "R"}, {"family": "Ter Haar", "given": "G", "initials": "G"}, {"family": "Mar\u0161al", "given": "K", "initials": "K"}, {"family": "Brezinka", "given": "C", "initials": "C"}, {"family": "Miloro", "given": "P", "initials": "P"}, {"family": "Basseal", "given": "J", "initials": "J"}, {"family": "Westerway", "given": "S C", "initials": "SC"}, {"family": "Abu-Rustum", "given": "R S", "initials": "RS"}, {"family": "Lees", "given": "C", "initials": "C"}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "Ultrasound Obstet Gynecol", "issn": "1469-0705", "volume": "55", "issue": "5", "pages": "709-712", "issn-l": null}, "abstract": null, "doi": "10.1002/uog.22027", "pmid": "32207189", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-08T06:57:10.479Z", "modified": "2020-12-10T08:59:30.636Z"}, {"entity": "publication", "iuid": "6da4506c756d45aa94417f1e53816578", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6da4506c756d45aa94417f1e53816578.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6da4506c756d45aa94417f1e53816578"}}, "title": "D\u00e9j\u00e0 vu: Stimulating open drug discovery for SARS-CoV-2.", "authors": [{"family": "Ekins", "given": "Sean", "initials": "S"}, {"family": "Mottin", "given": "Melina", "initials": "M"}, {"family": "Ramos", "given": "Paulo R P S", "initials": "PRPS"}, {"family": "Sousa", "given": "Bruna K P", "initials": "BKP"}, {"family": "Neves", "given": "Bruno Junior", "initials": "BJ"}, {"family": "Foil", "given": "Daniel H", "initials": "DH"}, {"family": "Zorn", "given": "Kimberley M", "initials": "KM"}, {"family": "Braga", "given": "Rodolpho C", "initials": "RC"}, {"family": "Coffee", "given": "Megan", "initials": "M"}, {"family": "Southan", "given": "Christopher", "initials": "C"}, {"family": "Puhl", "given": "Ana C", "initials": "AC"}, {"family": "Andrade", "given": "Carolina Horta", "initials": "CH"}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "Drug Discov Today", "issn": "1878-5832", "volume": "25", "issue": "5", "pages": "928-941", "issn-l": null}, "abstract": "In the past decade we have seen two major Ebola virus outbreaks in Africa, the Zika virus in Brazil and the Americas and the current pandemic of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There is a strong sense of d\u00e9j\u00e0 vu because there are still no effective treatments. In the COVID-19 pandemic, despite being a new virus, there are already drugs suggested as active in in vitro assays that are being repurposed in clinical trials. Promising SARS-CoV-2 viral targets and computational approaches are described and discussed. Here, we propose, based on open antiviral drug discovery approaches for previous outbreaks, that there could still be gaps in our approach to drug discovery.", "doi": "10.1016/j.drudis.2020.03.019", "pmid": "32320852", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1359-6446(20)30145-8"}, {"db": "pmc", "key": "PMC7167229"}], "notes": [], "created": "2020-11-30T15:55:34.499Z", "modified": "2020-11-30T15:55:34.523Z"}, {"entity": "publication", "iuid": "66b254f7d31346739b916455b018cd88", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66b254f7d31346739b916455b018cd88.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66b254f7d31346739b916455b018cd88"}}, "title": "Could severe COVID-19 be considered a complementopathy?", "authors": [{"family": "Chatzidionysiou", "given": "Katerina", "initials": "K", "orcid": "0000-0002-2669-1247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5cbb9ca8214426084a1def47e9029b2.json"}}, {"family": "Svenungsson", "given": "Elisabet", "initials": "E"}, {"family": "Faustini", "given": "Francesca", "initials": "F"}], "type": "journal-article", "published": "2020-05-00", "journal": {"title": "Lupus Sci Med", "issn": "2053-8790", "volume": "7", "issue": "1", "pages": "e000415", "issn-l": "2053-8790"}, "abstract": null, "doi": "10.1136/lupus-2020-000415", "pmid": "32430402", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "7/1/e000415"}, {"db": "pmc", "key": "PMC7246101"}], "notes": [], "created": "2020-11-25T09:07:20.316Z", "modified": "2021-12-06T13:01:45.301Z"}, {"entity": "publication", "iuid": "ee1e8b1ebe574af7a398a7a45d56a825", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee1e8b1ebe574af7a398a7a45d56a825.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee1e8b1ebe574af7a398a7a45d56a825"}}, "title": "Classification system and case definition for SARS-CoV-2 infection in pregnant women, fetuses, and neonates.", "authors": [{"family": "Shah", "given": "Prakesh S", "initials": "PS"}, {"family": "Diambomba", "given": "Yenge", "initials": "Y"}, {"family": "Acharya", "given": "Ganesh", "initials": "G"}, {"family": "Morris", "given": "Shaun K", "initials": "SK"}, {"family": "Bitnun", "given": "Ari", "initials": "A"}], "type": "editorial", "published": "2020-05-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "5", "pages": "565-568", "issn-l": "0001-6349"}, "abstract": null, "doi": "10.1111/aogs.13870", "pmid": "32277845", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7262318"}], "notes": [], "created": "2020-11-23T11:28:46.202Z", "modified": "2020-12-09T14:48:38.570Z"}, {"entity": "publication", "iuid": "63e8720413dc48c5b2a905b7a43ef905", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63e8720413dc48c5b2a905b7a43ef905.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63e8720413dc48c5b2a905b7a43ef905"}}, "title": "Caring for patients with cancer in the COVID-19 era.", "authors": [{"family": "van de Haar", "given": "Joris", "initials": "J"}, {"family": "Hoes", "given": "Louisa R", "initials": "LR"}, {"family": "Coles", "given": "Charlotte E", "initials": "CE"}, {"family": "Seamon", "given": "Kenneth", "initials": "K"}, {"family": "Fr\u00f6hling", "given": "Stefan", "initials": "S"}, {"family": "J\u00e4ger", "given": "Dirk", "initials": "D"}, {"family": "Valenza", "given": "Franco", "initials": "F"}, {"family": "de Braud", "given": "Filippo", "initials": "F"}, {"family": "De Petris", "given": "Luigi", "initials": "L"}, {"family": "Bergh", "given": "Jonas", "initials": "J"}, {"family": "Ernberg", "given": "Ingemar", "initials": "I"}, {"family": "Besse", "given": "Benjamin", "initials": "B"}, {"family": "Barlesi", "given": "Fabrice", "initials": "F"}, {"family": "Garralda", "given": "Elena", "initials": "E"}, {"family": "Piris-Gim\u00e9nez", "given": "Alejandro", "initials": "A"}, {"family": "Baumann", "given": "Michael", "initials": "M"}, {"family": "Apolone", "given": "Giovanni", "initials": "G"}, {"family": "Soria", "given": "Jean Charles", "initials": "JC"}, {"family": "Tabernero", "given": "Josep", "initials": "J"}, {"family": "Caldas", "given": "Carlos", "initials": "C"}, {"family": "Voest", "given": "Emile E", "initials": "EE"}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "volume": "26", "issue": "5", "pages": "665-671", "issn-l": "1078-8956"}, "abstract": "The current COVID-19 pandemic challenges oncologists to profoundly re-organize oncological care in order to dramatically reduce hospital visits and admissions and therapy-induced immune-related complications without compromising cancer outcomes. Since COVID-19 is a novel disease, guidance by scientific evidence is often unavailable, and impactful decisions are inevitably made on the basis of expert opinions. Here we report how the seven comprehensive cancer centers of Cancer Core Europe have organized their healthcare systems at an unprecedented scale and pace to make their operations 'pandemic proof'. We identify and discuss many commonalities, but also important local differences, and pinpoint critical research priorities to enable evidence-based remodeling of cancer care during the COVID-19 pandemic. Also, we discuss how the current situation offers a unique window of opportunity for assessing the effects of de-escalating anticancer regimens, which may fast-forward the development of more-refined and less-toxic treatments. By sharing our joint experiences, we offer a roadmap for proceeding and aim to mobilize the global research community to generate the data that are critically needed to offer the best possible care to patients.", "doi": "10.1038/s41591-020-0874-8", "pmid": "32405058", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-020-0874-8"}], "notes": [], "created": "2020-11-25T08:02:57.207Z", "modified": "2020-11-30T09:07:56.925Z"}, {"entity": "publication", "iuid": "0c354790c7ff4f10b5b8a21467a49ea5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c354790c7ff4f10b5b8a21467a49ea5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c354790c7ff4f10b5b8a21467a49ea5"}}, "title": "Burden and prevalence of prognostic factors for severe COVID-19 in Sweden.", "authors": [{"family": "G\u00e9mes", "given": "Katalin", "initials": "K", "orcid": "0000-0003-3335-7850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe866acb6ee744e7a413be9348fd3463.json"}}, {"family": "Talb\u00e4ck", "given": "Mats", "initials": "M"}, {"family": "Modig", "given": "Karin", "initials": "K"}, {"family": "Ahlbom", "given": "Anders", "initials": "A"}, {"family": "Berglund", "given": "Anita", "initials": "A"}, {"family": "Feychting", "given": "Maria", "initials": "M"}, {"family": "Matthews", "given": "Anthony A", "initials": "AA", "orcid": "0000-0002-1290-271X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8d087bad1264a57b5e9d6e3c264bf21.json"}}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "Eur J Epidemiol", "issn": "1573-7284", "issn-l": "0393-2990", "volume": "35", "issue": "5", "pages": "401-409"}, "abstract": "The World Health Organization and European Centre for Disease Prevention and Control suggest that individuals over the age of 70 years or with underlying cardiovascular disease, cancer, chronic obstructive pulmonary disease, asthma, or diabetes are at increased risk of severe COVID-19. However, the prevalence of these prognostic factors is unknown in many countries. We aimed to describe the burden and prevalence of prognostic factors of severe COVID-19 at national and county level in Sweden. We calculated the burden and prevalence of prognostic factors for severe COVID-19 based on records from the Swedish national health care and population registers for 3 years before 1st January 2016. 9,624,428 individuals were included in the study population. 22.1% had at least one prognostic factor for severe COVID-19 (2,131,319 individuals), and 1.6% had at least three factors (154,746 individuals). The prevalence of underlying medical conditions ranged from 0.8% with chronic obstructive pulmonary disease (78,516 individuals) to 7.4% with cardiovascular disease (708,090 individuals), and the county specific prevalence of at least one prognostic factor ranged from 19.2% in Stockholm (416,988 individuals) to 25.9% in Kalmar (60,005 individuals). We show that one in five individuals in Sweden is at increased risk of severe COVID-19. When compared with the critical care capacity at a local and national level, these results can aid authorities in optimally planning healthcare resources during the current pandemic. Findings can also be applied to underlying assumptions of disease burden in modelling efforts to support COVID-19 planning.", "doi": "10.1007/s10654-020-00646-z", "pmid": "32424571", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7233678"}, {"db": "pii", "key": "10.1007/s10654-020-00646-z"}], "notes": [], "created": "2021-06-14T06:37:37.102Z", "modified": "2023-06-19T14:52:50.448Z"}, {"entity": "publication", "iuid": "5506caef258d4d358aebefa4269ad746", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5506caef258d4d358aebefa4269ad746.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5506caef258d4d358aebefa4269ad746"}}, "title": "Allergic respiratory disease care in the COVID-19 era: A EUFOREA statement.", "authors": [{"family": "Scadding", "given": "Glenis K", "initials": "GK"}, {"family": "Hellings", "given": "Peter W", "initials": "PW"}, {"family": "Bachert", "given": "Claus", "initials": "C"}, {"family": "Bjermer", "given": "Leif", "initials": "L"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}, {"family": "Gevaert", "given": "Philippe", "initials": "P"}, {"family": "Kjeldsen", "given": "Anette", "initials": "A"}, {"family": "Kleine-Tebbe", "given": "Jorge", "initials": "J"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Muraro", "given": "Antonella", "initials": "A"}, {"family": "Roberts", "given": "Graham", "initials": "G"}, {"family": "Steinsvik", "given": "Andreas", "initials": "A"}, {"family": "Wagenmann", "given": "Martin", "initials": "M"}, {"family": "Wahn", "given": "Ulrich", "initials": "U"}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "World Allergy Organ J", "issn": "1939-4551", "volume": "13", "issue": "5", "pages": "100124", "issn-l": "1939-4551"}, "abstract": "Spring and Summer 2020 are unique in that the challenges of care for those suffering from pollen allergy coincide with the COVID-19 pandemic. Several considerations are important to allow optimal care of allergic rhinitis (AR) and asthma and hence prevention of coronavirus spread through sneezing, rhinorrhoea, and coughing. This compact overview of recommendations by the EUFOREA expert teams on allergic airway diseases and allergen-specific immunotherapy (AIT) is based on investigation of the current COVID-19 literature in association with the key words above and shared clinical experience of the experts involved. It deals with similarities and differences between AR and coronavirus infection, specific recommendations for allergic disease care in the COVID-19 era, including guidance on AIT.", "doi": "10.1016/j.waojou.2020.100124", "pmid": "32426089", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1939-4551(20)30027-2"}, {"db": "pii", "key": "100124"}, {"db": "pmc", "key": "PMC7229977"}], "notes": [], "created": "2020-11-25T08:35:35.107Z", "modified": "2020-12-09T11:41:32.455Z"}, {"entity": "publication", "iuid": "311580f756de4896bcebd20ebf489053", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/311580f756de4896bcebd20ebf489053.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/311580f756de4896bcebd20ebf489053"}}, "title": "A global recommendation for restrictive provision of fertility treatments during the COVID-19 pandemic.", "authors": [{"family": "Rodriguez-Wallberg", "given": "Kenny A", "initials": "KA"}, {"family": "Wikander", "given": "Ida", "initials": "I"}], "type": "editorial", "published": "2020-05-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "5", "pages": "569-570", "issn-l": "0001-6349"}, "abstract": "Editorial", "doi": "10.1111/aogs.13851", "pmid": "32270485", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7262212"}], "notes": [], "created": "2020-11-22T17:11:24.352Z", "modified": "2020-12-09T12:02:52.026Z"}, {"entity": "publication", "iuid": "aa52c6883f014263ae471d5182574d50", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aa52c6883f014263ae471d5182574d50.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aa52c6883f014263ae471d5182574d50"}}, "title": "[Covid-19 - deaths and analysis].", "authors": [{"family": "Modig", "given": "Karin", "initials": "K"}, {"family": "Ahlbom", "given": "Anders", "initials": "A"}, {"family": "Matthews", "given": "Anthony", "initials": "A"}], "type": "journal article", "published": "2020-04-30", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "volume": "117", "issue": null, "issn-l": "0023-7205"}, "abstract": "Mortality from Covid-19 is monitored in detail and compared between countries with different strategies against the virus. There is, however, often a lack of understanding of what is required in terms of measures and interpretation to enable correct comparisons. The number of deaths from Covid-19 is affected by the testing strategy and many other things that differ between countries. Therefore, today, the most reliable source for monitoring and comparing mortality from Covid-19 is total mortality. In Sweden, there is good correspondence of Covid-19 deaths and total mortality, with a tendency to a higher total mortality indicating some under-reporting of Covid-19 mortality.", "doi": null, "pmid": "32365212", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "F3XL"}], "notes": [], "created": "2020-12-10T07:26:31.854Z", "modified": "2023-01-13T14:49:29.532Z"}, {"entity": "publication", "iuid": "39986cc3e1564ff185d21484709b3b5c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/39986cc3e1564ff185d21484709b3b5c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/39986cc3e1564ff185d21484709b3b5c"}}, "title": "Physical Activity During the Coronavirus (COVID-19) Pandemic: Prevention of a Decline in Metabolic and Immunological Functions", "authors": [{"family": "Jakobsson", "given": "Johan", "initials": "J"}, {"family": "Malm", "given": "Christer", "initials": "C"}, {"family": "Furberg", "given": "Maria", "initials": "M"}, {"family": "Ekelund", "given": "Ulf", "initials": "U"}, {"family": "Svensson", "given": "Michael", "initials": "M"}], "type": "journal-article", "published": "2020-04-30", "journal": {"title": "Front Sports Act Living", "issn": "2624-9367", "volume": "2", "issue": null, "pages": "57", "issn-l": null}, "abstract": null, "doi": "10.3389/fspor.2020.00057", "pmid": "33345048", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7739799"}], "notes": [], "created": "2021-01-07T13:31:10.740Z", "modified": "2021-12-06T12:58:44.937Z"}, {"entity": "publication", "iuid": "68ad55ebf84544769e6502910e61ca19", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68ad55ebf84544769e6502910e61ca19.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68ad55ebf84544769e6502910e61ca19"}}, "title": "[Bats and humans].", "authors": [{"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-04-29", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": "Coronavirus (CoV) species are very common among animals, especially bats. The last two decades three large CoV outbreaks have appeared among humans; Severe Adult Respiratory Syndrome (SARS-1) in 2003, Middle East Respiratory Syndrome (MERS) in 2012 and SARS-2 in 2019, (COVID19). Also a large epidemic among swine, Swine Acute Diarrhea Syndrome (SADS) appeared in 2017 in China. There is a pool of coronavirus among bats which have the potential to infect humans through the ACE2 receptor, and new human epidemics can be expected. Therefore it is of great importance to develop new antivirals and vaccines against CoV as well as to improve the global infectious disease control of these infections.", "doi": null, "pmid": "32365214", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "F3UA"}], "notes": [], "created": "2020-11-25T07:21:34.085Z", "modified": "2021-12-06T12:57:40.712Z"}, {"entity": "publication", "iuid": "ce2f2dd752d04c168bef529206081d55", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ce2f2dd752d04c168bef529206081d55.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ce2f2dd752d04c168bef529206081d55"}}, "title": "Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs.", "authors": [{"family": "Neogi", "given": "Ujjwal", "initials": "U"}, {"family": "Hill", "given": "Kyle J", "initials": "KJ"}, {"family": "Ambikan", "given": "Anoop T", "initials": "AT"}, {"family": "Heng", "given": "Xiao", "initials": "X"}, {"family": "Quinn", "given": "Thomas P", "initials": "TP"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Sarafianos", "given": "Stefan G", "initials": "SG"}, {"family": "Singh", "given": "Kamal", "initials": "K"}], "type": "journal article", "published": "2020-04-26", "journal": {"title": "Pathogens", "issn": "2076-0817", "issn-l": "2076-0817", "volume": "9", "issue": "5", "pages": null}, "abstract": "Coronaviruses (CoVs) are positive-stranded RNA viruses that infect humans and animals. Infection by CoVs such as HCoV-229E, -NL63, -OC43 and -HKU1 leads to the common cold, short lasting rhinitis, cough, sore throat and fever. However, CoVs such as Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and the newest SARS-CoV-2 (the causative agent of COVID-19) lead to severe and deadly diseases with mortality rates ranging between ~1 to 35% depending on factors such as age and pre-existing conditions. Despite continuous global health threats to humans, there are no approved vaccines or drugs targeting human CoVs, and the recent outbreak of COVID-19 emphasizes an urgent need for therapeutic interventions. Using computational and bioinformatics tools, here we present the feasibility of reported broad-spectrum RNA polymerase inhibitors as anti- SARS-CoV-2 drugs targeting its main RNA polymerase, suggesting that investigational and approved nucleoside RNA polymerase inhibitors have potential as anti-SARS-CoV-2 drugs. However, we note that it is also possible for SARS-CoV-2 to evolve and acquire drug resistance mutations against these nucleoside inhibitors.", "doi": "10.3390/pathogens9050320", "pmid": "32357471", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "pathogens9050320"}, {"db": "pmc", "key": "PMC7281371"}], "notes": [], "created": "2020-11-25T07:17:57.790Z", "modified": "2021-02-26T08:45:25.910Z"}, {"entity": "publication", "iuid": "3271a08268724743b19292818e1e1faa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3271a08268724743b19292818e1e1faa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3271a08268724743b19292818e1e1faa"}}, "title": "The unsynchronized changes of CT image and nucleic acid detection in COVID-19: reports the two cases from Gansu, China.", "authors": [{"family": "Gao", "given": "Jing", "initials": "J"}, {"family": "Liu", "given": "Jun-Qiang", "initials": "JQ"}, {"family": "Wen", "given": "Heng-Jun", "initials": "HJ"}, {"family": "Liu", "given": "Hua", "initials": "H"}, {"family": "Hu", "given": "Wei-Dong", "initials": "WD"}, {"family": "Han", "given": "Xia", "initials": "X"}, {"family": "Li", "given": "Chuan-Xing", "initials": "CX"}, {"family": "Wang", "given": "Xiao-Jun", "initials": "XJ"}], "type": "case reports", "published": "2020-04-22", "journal": {"title": "Respir Res", "issn": "1465-993X", "volume": "21", "issue": "1", "pages": "96", "issn-l": "1465-9921"}, "abstract": "The novel coronavirus disease (COVID-19) outbreak started in December 2019 in Wuhan, China, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The CT image is used to assess the disease progress, whereas the continued two times of negative results from SARS-CoV-2 nucleic acid detection had been considered as a criterion for ending antiviral treatment. We compared the two COVID-19 cases with similar backgrounds and CT image repeated intervals under treatment. Our report highlighted the unsynchronized expression in the changes of CT image and nucleic acid detection in COVID-19, and lasting positive nucleic acid test result in patients recovered from pneumonia. It may be contributed to recognize the disease and improve prevention.", "doi": "10.1186/s12931-020-01363-7", "pmid": "32321530", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Provided in the article: CT images for 2 patients over 12 days", "description": null}], "notes": [], "created": "2020-11-23T11:43:52.411Z", "modified": "2021-02-26T08:45:48.033Z"}, {"entity": "publication", "iuid": "0ec3865d29d940b4ae522d567b465ae1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ec3865d29d940b4ae522d567b465ae1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ec3865d29d940b4ae522d567b465ae1"}}, "title": "Systematic Review of Important Viral Diseases in Africa in Light of the \u2018One Health\u2019 Concept", "authors": [{"family": "Chauhan", "given": "Ravendra P", "initials": "RP", "orcid": "0000-0002-4674-8255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d72198d117f42e094daefc52e6d8dfd.json"}}, {"family": "Dessie", "given": "Zelalem G", "initials": "ZG", "orcid": "0000-0001-9056-6822", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aef29117960a411cbfa4718222c2f690.json"}}, {"family": "Noreddin", "given": "Ayman", "initials": "A", "orcid": "0000-0003-4899-1168", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6ff11be70974f57aedb0646be4e17c1.json"}}, {"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME", "orcid": "0000-0002-1056-4761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58d2f06f64154a2f9b5b22ffbb7518a3.json"}}], "type": "journal-article", "published": "2020-04-20", "journal": {"title": "Pathogens", "issn": "2076-0817", "volume": "9", "issue": "4", "pages": "301", "issn-l": "2076-0817"}, "abstract": "Emerging and re-emerging viral diseases are of great public health concern. The recent emergence of Severe Acute Respiratory Syndrome (SARS) related coronavirus (SARS-CoV-2) in December 2019 in China, which causes COVID-19 disease in humans, and its current spread to several countries, leading to the first pandemic in history to be caused by a coronavirus, highlights the significance of zoonotic viral diseases. Rift Valley fever, rabies, West Nile, chikungunya, dengue, yellow fever, Crimean-Congo hemorrhagic fever, Ebola, and influenza viruses among many other viruses have been reported from different African countries. The paucity of information, lack of knowledge, limited resources, and climate change, coupled with cultural traditions make the African continent a hotspot for vector-borne and zoonotic viral diseases, which may spread globally. Currently, there is no information available on the status of virus diseases in Africa. This systematic review highlights the available information about viral diseases, including zoonotic and vector-borne diseases, reported in Africa. The findings will help us understand the trend of emerging and re-emerging virus diseases within the African continent. The findings recommend active surveillance of viral diseases and strict implementation of One Health measures in Africa to improve human public health and reduce the possibility of potential pandemics due to zoonotic viruses.", "doi": "10.3390/pathogens9040301", "pmid": "32325980", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "pathogens9040301"}, {"db": "pmc", "key": "PMC7238228"}], "notes": [], "created": "2020-11-19T14:19:08.521Z", "modified": "2021-12-06T12:56:28.620Z"}, {"entity": "publication", "iuid": "e0e3251f02a949849818c8647d613c7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e0e3251f02a949849818c8647d613c7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e0e3251f02a949849818c8647d613c7a"}}, "title": "Essential care of critical illness must not be forgotten in the COVID-19 pandemic.", "authors": [{"family": "Baker", "given": "Tim", "initials": "T"}, {"family": "Schell", "given": "Carl Otto", "initials": "CO"}, {"family": "Petersen", "given": "Dan Brun", "initials": "DB"}, {"family": "Sawe", "given": "Hendry", "initials": "H"}, {"family": "Khalid", "given": "Karima", "initials": "K"}, {"family": "Mndolo", "given": "Samson", "initials": "S"}, {"family": "Rylance", "given": "Jamie", "initials": "J"}, {"family": "McAuley", "given": "Daniel F", "initials": "DF"}, {"family": "Roy", "given": "Nobhojit", "initials": "N"}, {"family": "Marshall", "given": "John", "initials": "J"}, {"family": "Wallis", "given": "Lee", "initials": "L"}, {"family": "Molyneux", "given": "Elizabeth", "initials": "E"}], "type": "letter", "published": "2020-04-18", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "395", "issue": "10232", "pages": "1253-1254", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)30793-5", "pmid": "32246914", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)30793-5"}, {"db": "pmc", "key": "PMC7270584"}], "notes": [], "created": "2020-11-19T14:16:58.470Z", "modified": "2020-12-09T11:48:50.291Z"}, {"entity": "publication", "iuid": "111c43323baa4cdf84eeecd9a2dc7af9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/111c43323baa4cdf84eeecd9a2dc7af9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/111c43323baa4cdf84eeecd9a2dc7af9"}}, "title": "Steroid-responsive encephalitis in Covid-19 disease", "authors": [{"family": "Pilotto", "given": "Andrea", "initials": "A", "orcid": "0000-0003-2029-6606", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/221835a6e81a4a4eb7e302df55681c23.json"}}, {"family": "Odolini", "given": "Silvia", "initials": "S"}, {"family": "Masciocchi S", "given": "Stefano", "initials": "S"}, {"family": "Comelli", "given": "Agnese", "initials": "A"}, {"family": "Volonghi", "given": "Irene", "initials": "I"}, {"family": "Gazzina", "given": "Stefano", "initials": "S"}, {"family": "Nocivelli", "given": "Sara", "initials": "S"}, {"family": "Pezzini", "given": "Alessandro", "initials": "A"}, {"family": "Foc\u00e0", "given": "Emanuele", "initials": "E"}, {"family": "Caruso", "given": "Arnaldo", "initials": "A"}, {"family": "Leonardi", "given": "Matilde", "initials": "M"}, {"family": "Pasolini", "given": "Maria Pia", "initials": "MP"}, {"family": "Gasparotti R", "given": "Roberto", "initials": "R"}, {"family": "Castelli F", "given": "Francesco", "initials": "F"}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Padovani", "given": "Alessandro", "initials": "A"}], "type": "posted-content", "published": "2020-04-17", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.04.12.20062646", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-06-17T07:56:31.458Z", "modified": "2022-11-22T05:52:11.424Z"}, {"entity": "publication", "iuid": "f3f7011473894c83b2e34fa2ea6980ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f3f7011473894c83b2e34fa2ea6980ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f3f7011473894c83b2e34fa2ea6980ae"}}, "title": "ACE2 and coronavirus - a question of balance and dynamics?", "authors": [{"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A"}, {"family": "Sand\u00e9n", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2020-04-17", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": "The new SARS-CoV-2 virus enters cells via angiotensin-converting enzyme 2 (ACE2). ACE2 counteracts ACE and angiotensin II in the renin-angiotensin-aldosterone system (RAAS) and has critical functions in the lung and cardiovascular system. SARS-CoV was found to down-regulate ACE2, leaving angiotensin II unbalanced in affected organs. A similar effect of SARS-CoV-2 could partly explain risk factors and symptoms, and could potentially be treatable.", "doi": null, "pmid": "32314329", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "F3S3"}], "notes": [], "created": "2020-11-23T11:42:16.237Z", "modified": "2020-12-08T07:17:55.750Z"}, {"entity": "publication", "iuid": "8ff1da243d924635a0a9dbf4d20e1dce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ff1da243d924635a0a9dbf4d20e1dce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ff1da243d924635a0a9dbf4d20e1dce"}}, "title": "COVID-19 and Working Conditions in Health Care.", "authors": [{"family": "Theorell", "given": "T\u00f6res", "initials": "T"}], "type": "editorial", "published": "2020-04-16", "journal": {"title": "Psychother Psychosom", "issn": "1423-0348", "volume": "89", "issue": "4", "pages": "193-194", "issn-l": "0033-3190"}, "abstract": "Editorial", "doi": "10.1159/000507765", "pmid": "32299083", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "000507765"}, {"db": "pmc", "key": "PMC7206352"}], "notes": [], "created": "2020-11-23T11:30:26.354Z", "modified": "2020-12-09T14:49:06.411Z"}, {"entity": "publication", "iuid": "f7a80019e75845f4968677a6d71180bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7a80019e75845f4968677a6d71180bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7a80019e75845f4968677a6d71180bf"}}, "title": "Intervention strategies against COVID-19 and their estimated impact on Swedish healthcare capacity", "authors": [{"family": "Gardner", "given": "Jasmine M", "initials": "JM", "orcid": "0000-0002-6399-8504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/142f79739167491c9024e0fb17187f2f.json"}}, {"family": "Willem", "given": "Lander", "initials": "L", "orcid": "0000-0002-9210-1196", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/485594f08c334c55bcf8b1159db1befc.json"}}, {"family": "Van Der Wijngaart", "given": "Wouter", "initials": "W", "orcid": "0000-0001-8248-6670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08189699080c43df85b527923d969525.json"}}, {"family": "Kamerlin", "given": "Shina Caroline Lynn", "initials": "SCL", "orcid": "0000-0002-3190-1173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce94c3055e2b4f50b0ff4c16eac65658.json"}}, {"family": "Brusselaers", "given": "Nele", "initials": "N", "orcid": "0000-0003-0137-447X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8a4e9c84a5843c18e95fe0becb19506.json"}}, {"family": "Kasson", "given": "Peter", "initials": "P", "orcid": "0000-0002-3111-8103", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa48f188557f4339bbe05fa87f336b37.json"}}], "type": "posted-content", "published": "2020-04-15", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.04.11.20062133", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-17T08:36:28.175Z", "modified": "2022-11-22T05:52:03.951Z"}, {"entity": "publication", "iuid": "09ace0cf9b2b48a8b3235cd5c546314b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/09ace0cf9b2b48a8b3235cd5c546314b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/09ace0cf9b2b48a8b3235cd5c546314b"}}, "title": "Editorial: Covid-19 and Physical and Rehabilitation Medicine.", "authors": [{"family": "Borg", "given": "Kristian", "initials": "K"}, {"family": "Stam", "given": "Henk", "initials": "H"}], "type": "editorial", "published": "2020-04-15", "journal": {"title": "J Rehabil Med", "issn": "1651-2081", "volume": "52", "issue": "4", "pages": "jrm00045", "issn-l": null}, "abstract": null, "doi": "10.2340/16501977-2679", "pmid": "32286673", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-09T12:06:38.361Z", "modified": "2020-12-09T12:06:38.383Z"}, {"entity": "publication", "iuid": "f5023749413543a6bf5155fed22df06c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f5023749413543a6bf5155fed22df06c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f5023749413543a6bf5155fed22df06c"}}, "title": "Pediatric Endocrinology in the Time of the COVID-19 Pandemic.", "authors": [{"family": "Cianfarani", "given": "Stefano", "initials": "S"}], "type": "editorial", "published": "2020-04-09", "journal": {"title": "Horm Res Paediatr", "issn": "1663-2826", "volume": "92", "issue": "6", "pages": "345-346", "issn-l": "1663-2818"}, "abstract": "Editorial", "doi": "10.1159/000507703", "pmid": "32272473", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "000507703"}, {"db": "pmc", "key": "PMC7206355"}], "notes": [], "created": "2020-11-23T11:36:15.264Z", "modified": "2020-12-09T12:04:34.240Z"}, {"entity": "publication", "iuid": "9b929466d23449f79a9fc7631737267f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b929466d23449f79a9fc7631737267f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b929466d23449f79a9fc7631737267f"}}, "title": "F\u00f6rlorat luktsinne \u2013 m\u00f6jligt tidigt tecken p\u00e5 covid-19", "authors": [{"family": "N Lundstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Stj\u00e4rne", "given": "P\u00e4r", "initials": "P"}], "type": "journal article", "published": "2020-04-08", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "volume": "117", "issue": null, "pages": null, "issn-l": "0023-7205"}, "abstract": "Comment", "doi": null, "pmid": "32293016", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "F3P9"}], "notes": [], "created": "2020-11-23T11:29:43.793Z", "modified": "2021-12-06T12:51:58.143Z"}, {"entity": "publication", "iuid": "56b0c4045cd34bcfa299c09a7806480b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56b0c4045cd34bcfa299c09a7806480b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56b0c4045cd34bcfa299c09a7806480b"}}, "title": "Only strict quarantine measures can curb the coronavirus disease (COVID-19) outbreak in Italy, 2020", "authors": [{"family": "Sj\u00f6din", "given": "Henrik", "initials": "H"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Osman", "given": "Sarah", "initials": "S"}, {"family": "Farooq", "given": "Zia", "initials": "Z"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}], "type": "journal-article", "published": "2020-04-02", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "13", "issn-l": null}, "abstract": "Several Italian towns are under lockdown to contain the COVID-19 outbreak. The level of transmission reduction required for physical distancing interventions to mitigate the epidemic is a crucial question. We show that very high adherence to community quarantine (total stay-home policy) and a small household size is necessary for curbing the outbreak in a locked-down town. The larger the household size and amount of time in the public, the longer the lockdown period needed.", "doi": "10.2807/1560-7917.es.2020.25.13.2000280", "pmid": "32265005", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7140595"}], "notes": [], "created": "2020-12-09T12:02:19.916Z", "modified": "2021-12-06T12:50:36.128Z"}, {"entity": "publication", "iuid": "843a79f658174ae8bd88e64050cf7fc9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/843a79f658174ae8bd88e64050cf7fc9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/843a79f658174ae8bd88e64050cf7fc9"}}, "title": "COVID-19: GENERAL GUIDELINES FOR CARDIOVASCULAR SURGEONS (standard guidelines - subject to change).", "authors": [{"family": "Barros", "given": "Leila", "initials": "L"}, {"family": "Rivetti", "given": "Luiz Ant\u00f4nio", "initials": "LA"}, {"family": "Furlanetto", "given": "Beatriz Helena", "initials": "BH"}, {"family": "Teixeira", "given": "Eduardo Miranda", "initials": "EM"}, {"family": "Welikow", "given": "Alexandre", "initials": "A"}], "type": "editorial", "published": "2020-04-01", "journal": {"title": "Braz J Cardiovasc Surg", "issn": "1678-9741", "volume": "35", "issue": "2", "pages": "I-III", "issn-l": null}, "abstract": null, "doi": "10.21470/1678-9741-1-2020-0604", "pmid": "32369287", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7199979"}], "notes": [], "created": "2020-12-10T07:29:07.890Z", "modified": "2020-12-10T07:29:07.913Z"}, {"entity": "publication", "iuid": "377dff7d7d5d47d1861a22cd559bfac5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/377dff7d7d5d47d1861a22cd559bfac5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/377dff7d7d5d47d1861a22cd559bfac5"}}, "title": "The Current Clinically Relevant Findings on COVID-19 Pandemic.", "authors": [{"family": "Pergolizzi", "given": "Joseph V", "initials": "JV"}, {"family": "Magnusson", "given": "Peter", "initials": "P"}, {"family": "LeQuang", "given": "Jo Ann", "initials": "JA"}, {"family": "Breve", "given": "Frank", "initials": "F"}, {"family": "Paladini", "given": "Antonella", "initials": "A"}, {"family": "Rekatsina", "given": "Martina", "initials": "M"}, {"family": "Yeam", "given": "Cheng Teng", "initials": "CT"}, {"family": "Imani", "given": "Farnad", "initials": "F"}, {"family": "Saltelli", "given": "Giorgia", "initials": "G"}, {"family": "Taylor", "given": "Robert", "initials": "R"}, {"family": "Wollmuth", "given": "Charles", "initials": "C"}, {"family": "Varrassi", "given": "Giustino", "initials": "G"}], "type": "journal article", "published": "2020-04-00", "journal": {"title": "Anesth Pain Med", "issn": "2228-7523", "volume": "10", "issue": "2", "pages": "e103819", "issn-l": null}, "abstract": "The emergence of a novel coronavirus and coronavirus disease 2019 (COVID-19) represents a challenge to global healthcare. In the past 20 years, this is the third coronavirus that jumped the species barrier and infected humans. It is highly contagious but associated with low pathogenicity. First identified in Wuhan, China, a city of over 11 million, the disease has since spread to every continent except Antarctica. About 15% to 20% of all cases may be called severe, and it is believed many cases are asymptomatic. The average age of a person with COVID has been reported as 49 years. Worse outcomes are associated with geriatric populations and those with underlying diseases such as cardiovascular, respiratory disorders, and/or diabetes. The coronavirus, like other coronaviruses, is highly contagious and has a latency period of about 14 days. Most patients present with fever and a dry cough, but fever may be absent. Differential diagnosis can be challenging since influenza may present with similar symptoms. Chest radiography or computed tomography may be used to find evidence of secondary pneumonia. Nosocomial infection is of concern, and it has been reported that 3.8% of all cases with COVID-19 in that country involve healthcare workers in China. Most patients have mild disease, and supportive care suffices. A variety of repurposed and investigational drugs are being evaluated. There are currently no antiviral therapies or vaccines, even if many therapies are proposed. Hand hygiene, social distancing, and scientifically sound information are the best strategies at the moment to combat this epidemic.", "doi": "10.5812/aapm.103819", "pmid": "32754437", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7352949"}], "notes": [], "created": "2020-11-26T12:19:57.995Z", "modified": "2020-11-30T08:42:57.911Z"}, {"entity": "publication", "iuid": "39912591ca454520996acbfbd8dba3e6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/39912591ca454520996acbfbd8dba3e6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/39912591ca454520996acbfbd8dba3e6"}}, "title": "The COVID-19 pandemic: The \u2018black swan\u2019 for mental health care and a turning point for e-health", "authors": [{"family": "Wind", "given": "Tim R", "initials": "TR"}, {"family": "Rijkeboer", "given": "Marleen", "initials": "M"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Riper", "given": "Heleen", "initials": "H"}], "type": "journal-article", "published": "2020-04-00", "journal": {"title": "Internet Interv", "issn": "2214-7829", "volume": "20", "issue": null, "pages": "100317", "issn-l": "2214-7829"}, "abstract": "Editorial", "doi": "10.1016/j.invent.2020.100317", "pmid": "32289019", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2214-7829(20)30046-4"}, {"db": "pii", "key": "100317"}, {"db": "pmc", "key": "PMC7104190"}], "notes": [], "created": "2020-11-25T07:15:05.334Z", "modified": "2021-12-06T12:50:54.330Z"}, {"entity": "publication", "iuid": "a285403dbfaf42e893ce70fc3cd5bbde", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a285403dbfaf42e893ce70fc3cd5bbde.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a285403dbfaf42e893ce70fc3cd5bbde"}}, "title": "Novel corona virus disease (COVID\u201019) in pregnancy: What clinical recommendations to follow?", "authors": [{"family": "Liang", "given": "Huan", "initials": "H"}, {"family": "Acharya", "given": "Ganesh", "initials": "G", "orcid": "0000-0002-1997-3107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d1c2ac0dfb849d8b2374451e38cdcba.json"}}], "type": "journal-article", "published": "2020-04-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "0001-6349", "volume": "99", "issue": "4", "pages": "439-442", "issn-l": null}, "abstract": "Editorial", "doi": "10.1111/aogs.13836", "pmid": "32141062", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-22T16:58:43.722Z", "modified": "2021-12-06T12:50:02.730Z"}, {"entity": "publication", "iuid": "8760bdfa78534e329ab14882337e1681", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8760bdfa78534e329ab14882337e1681.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8760bdfa78534e329ab14882337e1681"}}, "title": "Harnessing the immune system via Fc\u03b3R function in immune therapy: a pathway to next\u2010gen mAbs", "authors": [{"family": "Chenoweth", "given": "Alicia M", "initials": "AM"}, {"family": "Wines", "given": "Bruce D", "initials": "BD"}, {"family": "Anania", "given": "Jessica C", "initials": "JC"}, {"family": "Mark Hogarth", "given": "P", "initials": "P"}], "type": "journal-article", "published": "2020-04-00", "journal": {"title": "Immunol Cell Biol", "issn": "0818-9641", "volume": "98", "issue": "4", "pages": "287-304", "issn-l": null}, "abstract": "The human fragment crystallizable (Fc)\u03b3 receptor (R) interacts with antigen-complexed immunoglobulin (Ig)G ligands to both activate and modulate a powerful network of inflammatory host-protective effector functions that are key to the normal physiology of immune resistance to pathogens. More than 100 therapeutic monoclonal antibodies (mAbs) are approved or in late stage clinical trials, many of which harness the potent Fc\u03b3R-mediated effector systems to varying degrees. This is most evident for antibodies targeting cancer cells inducing antibody-dependent killing or phagocytosis but is also true to some degree for the mAbs that neutralize or remove small macromolecules such as cytokines or other Igs. The use of mAb therapeutics has also revealed a \"scaffolding\" role for Fc\u03b3R which, in different contexts, may either underpin the therapeutic mAb action such as immune agonism or trigger catastrophic adverse effects. The still unmet therapeutic need in many cancers, inflammatory diseases or emerging infections such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires increased effort on the development of improved and novel mAbs. A more mature appreciation of the immunobiology of individual Fc\u03b3R function and the complexity of the relationships between Fc\u03b3Rs and antibodies is fueling efforts to develop more potent \"next-gen\" therapeutic antibodies. Such development strategies now include focused glycan or protein engineering of the Fc to increase affinity and/or tailor specificity for selective engagement of individual activating Fc\u03b3Rs or the inhibitory Fc\u03b3RIIb or alternatively, for the ablation of Fc\u03b3R interaction altogether. This review touches on recent aspects of Fc\u03b3R and IgG immunobiology and its relationship with the present and future actions of therapeutic mAbs.", "doi": "10.1111/imcb.12326", "pmid": "32157732", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7228307"}], "notes": [], "created": "2020-11-22T09:23:12.446Z", "modified": "2021-12-06T12:49:37.522Z"}, {"entity": "publication", "iuid": "0468f23a15f441f5b13ce8e44305625a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0468f23a15f441f5b13ce8e44305625a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0468f23a15f441f5b13ce8e44305625a"}}, "title": "A hundred days into the coronavirus disease (COVID-19) pandemic.", "authors": [{"family": "Steffens", "given": "Ines", "initials": "I"}], "type": "editorial", "published": "2020-04-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "14", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.14.2000550", "pmid": "32290905", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7160442"}], "notes": [], "created": "2020-12-09T12:07:21.950Z", "modified": "2021-12-06T12:49:10.360Z"}, {"entity": "publication", "iuid": "924a0d531a614d58a8ed52f344fb1932", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/924a0d531a614d58a8ed52f344fb1932.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/924a0d531a614d58a8ed52f344fb1932"}}, "title": "Novel Coronavirus Infection (COVID-19) in Humans: A Scoping Review and Meta-Analysis.", "authors": [{"family": "Borges do Nascimento", "given": "Israel J\u00fanior", "initials": "IJ"}, {"family": "Cacic", "given": "Nensi", "initials": "N"}, {"family": "Abdulazeem", "given": "Hebatullah Mohamed", "initials": "HM"}, {"family": "von Groote", "given": "Thilo Caspar", "initials": "TC"}, {"family": "Jayarajah", "given": "Umesh", "initials": "U"}, {"family": "Weerasekara", "given": "Ishanka", "initials": "I"}, {"family": "Esfahani", "given": "Meisam Abdar", "initials": "MA"}, {"family": "Civile", "given": "Vinicius Tassoni", "initials": "VT"}, {"family": "Marusic", "given": "Ana", "initials": "A"}, {"family": "Jeroncic", "given": "Ana", "initials": "A"}, {"family": "Carvas Junior", "given": "Nelson", "initials": "N"}, {"family": "Pericic", "given": "Tina Poklepovic", "initials": "TP"}, {"family": "Zakarija-Grkovic", "given": "Irena", "initials": "I"}, {"family": "Meirelles Guimar\u00e3es", "given": "Silvana Mangeon", "initials": "SM"}, {"family": "Luigi Bragazzi", "given": "Nicola", "initials": "N"}, {"family": "Bjorklund", "given": "Maria", "initials": "M"}, {"family": "Sofi-Mahmudi", "given": "Ahmad", "initials": "A"}, {"family": "Altujjar", "given": "Mohammad", "initials": "M"}, {"family": "Tian", "given": "Maoyi", "initials": "M"}, {"family": "Arcani", "given": "Diana Maria Cespedes", "initials": "DMC"}, {"family": "O'Math\u00fana", "given": "D\u00f3nal P", "initials": "DP"}, {"family": "Marcolino", "given": "Milena Soriano", "initials": "MS"}], "type": "journal article", "published": "2020-03-30", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "9", "issue": "4", "issn-l": "2077-0383"}, "abstract": "A growing body of literature on the 2019 novel coronavirus (SARS-CoV-2) is becoming available, but a synthesis of available data has not been conducted. We performed a scoping review of currently available clinical, epidemiological, laboratory, and chest imaging data related to the SARS-CoV-2 infection. We searched MEDLINE, Cochrane CENTRAL, EMBASE, Scopus and LILACS from 01 January 2019 to 24 February 2020. Study selection, data extraction and risk of bias assessment were performed by two independent reviewers. Qualitative synthesis and meta-analysis were conducted using the clinical and laboratory data, and random-effects models were applied to estimate pooled results. A total of 61 studies were included (59,254 patients). The most common disease-related symptoms were fever (82%, 95% confidence interval (CI) 56%-99%; n = 4410), cough (61%, 95% CI 39%-81%; n = 3985), muscle aches and/or fatigue (36%, 95% CI 18%-55%; n = 3778), dyspnea (26%, 95% CI 12%-41%; n = 3700), headache in 12% (95% CI 4%-23%, n = 3598 patients), sore throat in 10% (95% CI 5%-17%, n = 1387) and gastrointestinal symptoms in 9% (95% CI 3%-17%, n = 1744). Laboratory findings were described in a lower number of patients and revealed lymphopenia (0.93 \u00d7 109/L, 95% CI 0.83-1.03 \u00d7 109/L, n = 464) and abnormal C-reactive protein (33.72 mg/dL, 95% CI 21.54-45.91 mg/dL; n = 1637). Radiological findings varied, but mostly described ground-glass opacities and consolidation. Data on treatment options were limited. All-cause mortality was 0.3% (95% CI 0.0%-1.0%; n = 53,631). Epidemiological studies showed that mortality was higher in males and elderly patients. The majority of reported clinical symptoms and laboratory findings related to SARS-CoV-2 infection are non-specific. Clinical suspicion, accompanied by a relevant epidemiological history, should be followed by early imaging and virological assay.", "doi": "10.3390/jcm9040941", "pmid": "32235486", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jcm9040941"}, {"db": "pmc", "key": "PMC7230636"}], "notes": [], "created": "2020-11-30T16:01:46.945Z", "modified": "2020-12-09T11:48:12.765Z"}, {"entity": "publication", "iuid": "b9110c7439e54c1a983a6e0fbc7748c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9110c7439e54c1a983a6e0fbc7748c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9110c7439e54c1a983a6e0fbc7748c9"}}, "title": "COVID-19: towards controlling of a pandemic.", "authors": [{"family": "Bedford", "given": "Juliet", "initials": "J"}, {"family": "Enria", "given": "Delia", "initials": "D"}, {"family": "Giesecke", "given": "Johan", "initials": "J"}, {"family": "Heymann", "given": "David L", "initials": "DL"}, {"family": "Ihekweazu", "given": "Chikwe", "initials": "C"}, {"family": "Kobinger", "given": "Gary", "initials": "G"}, {"family": "Lane", "given": "H Clifford", "initials": "HC"}, {"family": "Memish", "given": "Ziad", "initials": "Z"}, {"family": "Oh", "given": "Myoung-Don", "initials": "MD"}, {"family": "Sall", "given": "Amadou Alpha", "initials": "AA"}, {"family": "Schuchat", "given": "Anne", "initials": "A"}, {"family": "Ungchusak", "given": "Kumnuan", "initials": "K"}, {"family": "Wieler", "given": "Lothar H", "initials": "LH"}, {"family": "WHO Strategic and Technical Advisory Group for Infectious Hazards", "given": "", "initials": ""}], "type": "journal article", "published": "2020-03-28", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "395", "issue": "10229", "pages": "1015-1018", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)30673-5", "pmid": "32197103", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)30673-5"}, {"db": "pmc", "key": "PMC7270596"}], "notes": [], "created": "2020-11-22T17:02:19.626Z", "modified": "2020-12-10T09:04:01.272Z"}, {"entity": "publication", "iuid": "551696f1ed29428c891af663c479317e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/551696f1ed29428c891af663c479317e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/551696f1ed29428c891af663c479317e"}}, "title": "The Fear of COVID-19 Scale: Development and Initial Validation.", "authors": [{"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Imani", "given": "Vida", "initials": "V"}, {"family": "Saffari", "given": "Mohsen", "initials": "M"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "case reports", "published": "2020-03-27", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "issn-l": null, "volume": null, "issue": null, "pages": "1-9"}, "abstract": "The emergence of the COVID-19 and its consequences has led to fears, worries, and anxiety among individuals worldwide. The present study developed the Fear of COVID-19 Scale (FCV-19S) to complement the clinical efforts in preventing the spread and treating of COVID-19 cases.\r\n\r\nThe sample comprised 717 Iranian participants. The items of the FCV-19S were constructed based on extensive review of existing scales on fears, expert evaluations, and participant interviews. Several psychometric tests were conducted to ascertain its reliability and validity properties.\r\n\r\nAfter panel review and corrected item-total correlation testing, seven items with acceptable corrected item-total correlation (0.47 to 0.56) were retained and further confirmed by significant and strong factor loadings (0.66 to 0.74). Also, other properties evaluated using both classical test theory and Rasch model were satisfactory on the seven-item scale. More specifically, reliability values such as internal consistency ( \u03b1 = .82) and test-retest reliability (ICC = .72) were acceptable. Concurrent validity was supported by the Hospital Anxiety and Depression Scale (with depression, r = 0.425 and anxiety, r = 0.511) and the Perceived Vulnerability to Disease Scale (with perceived infectability, r = 0.483 and germ aversion, r = 0.459).\r\n\r\nThe Fear of COVID-19 Scale, a seven-item scale, has robust psychometric properties. It is reliable and valid in assessing fear of COVID-19 among the general population and will also be useful in allaying COVID-19 fears among individuals.", "doi": "10.1007/s11469-020-00270-8", "pmid": "32226353", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "270"}, {"db": "pmc", "key": "PMC7100496"}], "notes": [], "created": "2020-11-30T16:01:48.181Z", "modified": "2022-11-10T07:58:14.325Z"}, {"entity": "publication", "iuid": "c6ab29c6e3564897a13b3610d928cca6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c6ab29c6e3564897a13b3610d928cca6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c6ab29c6e3564897a13b3610d928cca6"}}, "title": "Combating COVID-19-The role of robotics in managing public health and infectious diseases.", "authors": [{"family": "Yang", "given": "Guang-Zhong", "initials": "GZ"}, {"family": "J Nelson", "given": "Bradley", "initials": "B"}, {"family": "Murphy", "given": "Robin R", "initials": "RR"}, {"family": "Choset", "given": "Howie", "initials": "H"}, {"family": "Christensen", "given": "Henrik", "initials": "H"}, {"family": "H Collins", "given": "Steven", "initials": "S"}, {"family": "Dario", "given": "Paolo", "initials": "P"}, {"family": "Goldberg", "given": "Ken", "initials": "K"}, {"family": "Ikuta", "given": "Koji", "initials": "K"}, {"family": "Jacobstein", "given": "Neil", "initials": "N"}, {"family": "Kragic", "given": "Danica", "initials": "D"}, {"family": "Taylor", "given": "Russell H", "initials": "RH"}, {"family": "McNutt", "given": "Marcia", "initials": "M"}], "type": "editorial", "published": "2020-03-25", "journal": {"title": "Sci Robot", "issn": "2470-9476", "volume": "5", "issue": "40", "issn-l": null}, "abstract": "COVID-19 may drive sustained research in robotics to address risks of infectious diseases.", "doi": "10.1126/scirobotics.abb5589", "pmid": "33022599", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "5/40/eabb5589"}], "notes": [], "created": "2020-12-01T18:16:32.224Z", "modified": "2020-12-01T18:16:32.248Z"}, {"entity": "publication", "iuid": "4dbadc63c07b41d4b20a9a1492bba241", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4dbadc63c07b41d4b20a9a1492bba241.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4dbadc63c07b41d4b20a9a1492bba241"}}, "title": "Hypertension and Diabetes Delay the Viral Clearance in COVID-19 Patients", "authors": [{"family": "Chen", "given": "Xiaoping", "initials": "X"}, {"family": "Hu", "given": "Wenjia", "initials": "W"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Mo", "given": "Pingzheng", "initials": "P"}, {"family": "Zhang", "given": "Yongxi", "initials": "Y"}, {"family": "Jiang", "given": "Qunqun", "initials": "Q"}, {"family": "Ma", "given": "Zhiyong", "initials": "Z"}, {"family": "Cao", "given": "Qian", "initials": "Q"}, {"family": "Deng", "given": "Liping", "initials": "L"}, {"family": "Song", "given": "Shihui", "initials": "S"}, {"family": "Zheng", "given": "Ruiying", "initials": "R"}, {"family": "Gao", "given": "Shicheng", "initials": "S"}, {"family": "Ke", "given": "Hengning", "initials": "H"}, {"family": "Gui", "given": "Xien", "initials": "X"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Li", "given": "Jinlin", "initials": "J"}, {"family": "Lindahl", "given": "Johanna F", "initials": "JF"}, {"family": "Xiong", "given": "Yong", "initials": "Y"}], "type": "posted-content", "published": "2020-03-24", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.03.22.20040774", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-17T08:39:04.505Z", "modified": "2023-06-19T15:38:10.655Z"}, {"entity": "publication", "iuid": "5156c5f3e35b41e8b789fbc7915c044c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5156c5f3e35b41e8b789fbc7915c044c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5156c5f3e35b41e8b789fbc7915c044c"}}, "title": "Covid-19 \u2013 uppdatering om klinisk bild och behandling", "authors": [{"family": "Glans", "given": "Hedvig", "initials": "H"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Aleman", "given": "Soo", "initials": "S"}], "type": "journal article", "published": "2020-03-23", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": null, "doi": null, "pmid": "32266709", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "F3HW"}], "notes": [], "created": "2020-11-22T17:09:54.906Z", "modified": "2021-02-26T08:45:48.147Z"}, {"entity": "publication", "iuid": "82ccc1b68ddb4510ae5faf4cd89ac89e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82ccc1b68ddb4510ae5faf4cd89ac89e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82ccc1b68ddb4510ae5faf4cd89ac89e"}}, "title": "COVID-19 healthcare demand and mortality in Sweden in response to non-pharmaceutical (NPIs) mitigation and suppression scenarios", "authors": [{"family": "Sj\u00f6din", "given": "Henrik", "initials": "H"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}, {"family": "Br\u00e4nnstr\u00f6m", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Farooq", "given": "Zia", "initials": "Z"}, {"family": "Kriit", "given": "Hedi Katre", "initials": "HK"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "\u00c5str\u00f6m", "given": "Christofer", "initials": "C"}, {"family": "Thunberg", "given": "Johan", "initials": "J"}, {"family": "S\u00f6derquist", "given": "M\u00e5rten", "initials": "M"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}], "type": "posted-content", "published": "2020-03-23", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.03.20.20039594", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-14T06:39:24.677Z", "modified": "2022-11-22T05:51:45.396Z"}, {"entity": "publication", "iuid": "130e2061ba1041cc976a4b994ce63471", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/130e2061ba1041cc976a4b994ce63471.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/130e2061ba1041cc976a4b994ce63471"}}, "title": "The reproductive number of COVID-19 is higher compared to SARS coronavirus.", "authors": [{"family": "Liu", "given": "Ying", "initials": "Y"}, {"family": "Gayle", "given": "Albert A", "initials": "AA"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}], "type": "journal article", "published": "2020-03-13", "journal": {"title": "J Travel Med", "issn": "1708-8305", "issn-l": null, "volume": "27", "issue": "2", "pages": null}, "abstract": null, "doi": "10.1093/jtm/taaa021", "pmid": "32052846", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5735319"}, {"db": "pmc", "key": "PMC7074654"}], "notes": [], "created": "2020-11-30T16:01:53.074Z", "modified": "2020-12-11T14:18:52.131Z"}, {"entity": "publication", "iuid": "2e73a2c38f314f2ca50f2e333abb227c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e73a2c38f314f2ca50f2e333abb227c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e73a2c38f314f2ca50f2e333abb227c"}}, "title": "Potential impact of seasonal forcing on a SARS-CoV-2 pandemic.", "authors": [{"family": "Neher", "given": "Richard A", "initials": "RA"}, {"family": "Dyrdak", "given": "Robert", "initials": "R", "orcid": "0000-0001-8456-4898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98ad76a0e144478cb3ceabd05c9928b0.json"}}, {"family": "Druelle", "given": "Valentin", "initials": "V"}, {"family": "Hodcroft", "given": "Emma B", "initials": "EB"}, {"family": "Albert", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2020-03-09", "journal": {"title": "Swiss Med Wkly", "issn": "1424-3997", "issn-l": "0036-7672", "volume": "150", "issue": null, "pages": "w20224"}, "abstract": "A novel coronavirus (SARS-CoV-2) first detected in Wuhan, China, has spread rapidly since December 2019, causing more than 100,000 confirmed infections and 4000 fatalities (as of 10 March 2020). The outbreak has been declared a pandemic by the WHO on Mar 11, 2020. Here, we explore how seasonal variation in transmissibility could modulate a SARS-CoV-2 pandemic. Data from routine diagnostics show a strong and consistent seasonal variation of the four endemic coronaviruses (229E, HKU1, NL63, OC43) and we parameterise our model for SARS-CoV-2 using these data. The model allows for many subpopulations of different size with variable parameters. Simulations of different scenarios show that plausible parameters result in a small peak in early 2020 in temperate regions of the Northern Hemisphere and a larger peak in winter 2020/2021. Variation in transmission and migration rates can result in substantial variation in prevalence between regions. While the uncertainty in parameters is large, the scenarios we explore show that transient reductions in the incidence rate might be due to a combination of seasonal variation and infection control efforts but do not necessarily mean the epidemic is contained. Seasonal forcing on SARS-CoV-2 should thus be taken into account in the further monitoring of the global transmission. The likely aggregated effect of seasonal variation, infection control measures, and transmission rate variation is a prolonged pandemic wave with lower prevalence at any given time, thereby providing a window of opportunity for better preparation of health care systems.", "doi": "10.4414/smw.2020.20224", "pmid": "32176808", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "Swiss Med Wkly. 2020;150:w20224"}], "notes": [], "created": "2020-11-17T17:38:57.263Z", "modified": "2023-06-19T14:45:01.419Z"}, {"entity": "publication", "iuid": "f4cd5fc5b81b412089e6ad0921ece7a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f4cd5fc5b81b412089e6ad0921ece7a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f4cd5fc5b81b412089e6ad0921ece7a0"}}, "title": "Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses.", "authors": [{"family": "Raoult", "given": "Didier", "initials": "D"}, {"family": "Zumla", "given": "Alimuddin", "initials": "A"}, {"family": "Locatelli", "given": "Franco", "initials": "F"}, {"family": "Ippolito", "given": "Giuseppe", "initials": "G"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}], "type": "editorial", "published": "2020-03-02", "journal": {"title": "Cell Stress", "issn": "2523-0204", "volume": "4", "issue": "4", "pages": "66-75", "issn-l": "2523-0204"}, "abstract": "Coronaviruses (CoVs) are a large family of enveloped, positive-strand RNA viruses. Four human CoVs (HCoVs), the non-severe acute respiratory syndrome (SARS)-like HCoVs (namely HCoV 229E, NL63, OC43, and HKU1), are globally endemic and account for a substantial fraction of upper respiratory tract infections. Non-SARS-like CoV can occasionally produce severe diseases in frail subjects but do not cause any major (fatal) epidemics. In contrast, SARS like CoVs (namely SARS-CoV and Middle-East respiratory syndrome coronavirus, MERS-CoV) can cause intense short-lived fatal outbreaks. The current epidemic caused by the highly contagious SARS-CoV-2 and its rapid spread globally is of major concern. There is scanty knowledge on the actual pandemic potential of this new SARS-like virus. It might be speculated that SARS-CoV-2 epidemic is grossly underdiagnosed and that the infection is silently spreading across the globe with two consequences: (i) clusters of severe infections among frail subjects could haphazardly occur linked to unrecognized index cases; (ii) the current epidemic could naturally fall into a low-level endemic phase when a significant number of subjects will have developed immunity. Understanding the role of paucisymptomatic subjects and stratifying patients according to the risk of developing severe clinical presentations is pivotal for implementing reasonable measures to contain the infection and to reduce its mortality. Whilst the future evolution of this epidemic remains unpredictable, classic public health strategies must follow rational patterns. The emergence of yet another global epidemic underscores the permanent challenges that infectious diseases pose and underscores the need for global cooperation and preparedness, even during inter-epidemic periods.", "doi": "10.15698/cst2020.04.216", "pmid": "32292881", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "CST0270E115"}, {"db": "pmc", "key": "PMC7064018"}], "notes": [], "created": "2020-11-23T11:27:23.267Z", "modified": "2020-12-09T12:09:26.162Z"}, {"entity": "publication", "iuid": "6067731d14094c8ca594582c6a13d5ab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6067731d14094c8ca594582c6a13d5ab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6067731d14094c8ca594582c6a13d5ab"}}, "title": "Updated rapid risk assessment from ECDC on the outbreak of COVID-19: increased transmission globally.", "authors": [], "type": "journal article", "published": "2020-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "9", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.9.2003051", "pmid": "32156331", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7068166"}], "notes": [], "created": "2020-12-08T06:53:18.558Z", "modified": "2020-12-10T09:04:59.875Z"}, {"entity": "publication", "iuid": "6e5b06134a9e41f4a197a3dba1698631", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e5b06134a9e41f4a197a3dba1698631.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e5b06134a9e41f4a197a3dba1698631"}}, "title": "Updated rapid risk assessment from ECDC on the novel coronavirus disease 2019 (COVID-19) pandemic: increased transmission in the EU/EEA and the UK.", "authors": [{"family": "Eurosurveillance editorial team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "25", "issue": "10", "pages": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.10.2003121", "pmid": "32183937", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7078827"}], "notes": [], "created": "2020-12-08T06:55:01.572Z", "modified": "2020-12-10T09:04:15.038Z"}, {"entity": "publication", "iuid": "555a9a24a05249b9b88c00e2e32d0ac4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/555a9a24a05249b9b88c00e2e32d0ac4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/555a9a24a05249b9b88c00e2e32d0ac4"}}, "title": "Rapidly increasing cumulative incidence of coronavirus disease (COVID-19) in the European Union/European Economic Area and the United Kingdom, 1 January to 15 March 2020.", "authors": [{"family": "Kinross", "given": "Pete", "initials": "P"}, {"family": "Suetens", "given": "Carl", "initials": "C"}, {"family": "Gomes Dias", "given": "Joana", "initials": "J"}, {"family": "Alexakis", "given": "Leonidas", "initials": "L"}, {"family": "Wijermans", "given": "Ariana", "initials": "A"}, {"family": "Colzani", "given": "Edoardo", "initials": "E"}, {"family": "Monnet", "given": "Dominique L", "initials": "DL"}, {"family": "ECDC Public Health Emergency Team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "25", "issue": "11", "pages": null}, "abstract": "The cumulative incidence of coronavirus disease (COVID-19) cases is showing similar trends in European Union/European Economic Area countries and the United Kingdom confirming that, while at a different stage depending on the country, the COVID-19 pandemic is progressing rapidly in all countries. Based on the experience from Italy, countries, hospitals and intensive care units should increase their preparedness for a surge of patients with COVID-19 who will require healthcare, and in particular intensive care.", "doi": "10.2807/1560-7917.ES.2020.25.11.2000285", "pmid": "32186277", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7096777"}], "notes": [], "created": "2020-12-08T06:56:51.256Z", "modified": "2021-02-26T08:45:48.168Z"}, {"entity": "publication", "iuid": "eea6eb2eee9947eead710b14e91c253a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eea6eb2eee9947eead710b14e91c253a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eea6eb2eee9947eead710b14e91c253a"}}, "title": "Potential scenarios for the progression of a COVID-19 epidemic in the European Union and the European Economic Area, March 2020.", "authors": [{"family": "Johnson", "given": "Helen C", "initials": "HC"}, {"family": "Gossner", "given": "C\u00e9line M", "initials": "CM"}, {"family": "Colzani", "given": "Edoardo", "initials": "E"}, {"family": "Kinsman", "given": "John", "initials": "J"}, {"family": "Alexakis", "given": "Leonidas", "initials": "L"}, {"family": "Beaut\u00e9", "given": "Julien", "initials": "J"}, {"family": "W\u00fcrz", "given": "Andrea", "initials": "A"}, {"family": "Tsolova", "given": "Svetla", "initials": "S"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Ekdahl", "given": "Karl", "initials": "K"}], "type": "journal article", "published": "2020-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "9", "issn-l": null}, "abstract": "Two months after the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the possibility of established and widespread community transmission in the European Union and European Economic Area (EU/EEA) is becoming more likely. We provide scenarios for use in preparedness for a possible widespread epidemic. The EU/EEA is moving towards the 'limited sustained transmission' phase. We propose actions to prepare for potential mitigation phases and coordinate efforts to protect the health of citizens.", "doi": "10.2807/1560-7917.ES.2020.25.9.2000202", "pmid": "32156332", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7068161"}], "notes": [], "created": "2020-12-08T06:54:09.547Z", "modified": "2020-12-10T09:04:40.162Z"}, {"entity": "publication", "iuid": "9dc9d035aaaf46ebba4567bc2ce6c865", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9dc9d035aaaf46ebba4567bc2ce6c865.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9dc9d035aaaf46ebba4567bc2ce6c865"}}, "title": "First cases of coronavirus disease 2019 (COVID-19) in the WHO European Region, 24 January to 21 February 2020.", "authors": [{"family": "Spiteri", "given": "Gianfranco", "initials": "G"}, {"family": "Fielding", "given": "James", "initials": "J"}, {"family": "Diercke", "given": "Michaela", "initials": "M"}, {"family": "Campese", "given": "Christine", "initials": "C"}, {"family": "Enouf", "given": "Vincent", "initials": "V"}, {"family": "Gaymard", "given": "Alexandre", "initials": "A"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Sognamiglio", "given": "Paola", "initials": "P"}, {"family": "Sierra Moros", "given": "Maria Jos\u00e9", "initials": "MJ"}, {"family": "Riutort", "given": "Antonio Nicolau", "initials": "AN"}, {"family": "Demina", "given": "Yulia V", "initials": "YV"}, {"family": "Mahieu", "given": "Romain", "initials": "R"}, {"family": "Broas", "given": "Markku", "initials": "M"}, {"family": "Bengn\u00e9r", "given": "Malin", "initials": "M"}, {"family": "Buda", "given": "Silke", "initials": "S"}, {"family": "Schilling", "given": "Julia", "initials": "J"}, {"family": "Filleul", "given": "Laurent", "initials": "L"}, {"family": "Lepoutre", "given": "Agn\u00e8s", "initials": "A"}, {"family": "Saura", "given": "Christine", "initials": "C"}, {"family": "Mailles", "given": "Alexandra", "initials": "A"}, {"family": "Levy-Bruhl", "given": "Daniel", "initials": "D"}, {"family": "Coignard", "given": "Bruno", "initials": "B"}, {"family": "Bernard-Stoecklin", "given": "Sibylle", "initials": "S"}, {"family": "Behillil", "given": "Sylvie", "initials": "S"}, {"family": "van der Werf", "given": "Sylvie", "initials": "S"}, {"family": "Valette", "given": "Martine", "initials": "M"}, {"family": "Lina", "given": "Bruno", "initials": "B"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Nicastri", "given": "Emanuele", "initials": "E"}, {"family": "Casas", "given": "Inmaculada", "initials": "I"}, {"family": "Larrauri", "given": "Amparo", "initials": "A"}, {"family": "Salom Castell", "given": "Magdalena", "initials": "M"}, {"family": "Pozo", "given": "Francisco", "initials": "F"}, {"family": "Maksyutov", "given": "Rinat A", "initials": "RA"}, {"family": "Martin", "given": "Charlotte", "initials": "C"}, {"family": "Van Ranst", "given": "Marc", "initials": "M"}, {"family": "Bossuyt", "given": "Nathalie", "initials": "N"}, {"family": "Siira", "given": "Lotta", "initials": "L"}, {"family": "Sane", "given": "Jussi", "initials": "J"}, {"family": "Tegmark-Wisell", "given": "Karin", "initials": "K"}, {"family": "Palm\u00e9rus", "given": "Maria", "initials": "M"}, {"family": "Broberg", "given": "Eeva K", "initials": "EK"}, {"family": "Beaut\u00e9", "given": "Julien", "initials": "J"}, {"family": "Jorgensen", "given": "Pernille", "initials": "P"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Pereyaslov", "given": "Dmitriy", "initials": "D"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Pukkila", "given": "Jukka", "initials": "J"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "Olsen", "given": "Sonja", "initials": "S"}, {"family": "Ciancio", "given": "Bruno Christian", "initials": "BC"}], "type": "journal article", "published": "2020-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "9", "issn-l": null}, "abstract": "In the WHO European Region, COVID-19 surveillance was implemented 27 January 2020. We detail the first European cases. As at 21 February, nine European countries reported 47 cases. Among 38 cases studied, 21 were linked to two clusters in Germany and France, 14 were infected in China. Median case age was 42 years; 25 were male. Late detection of the clusters' index cases delayed isolation of further local cases. As at 5 March, there were 4,250 cases.", "doi": "10.2807/1560-7917.ES.2020.25.9.2000178", "pmid": "32156327", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7068164"}], "notes": [], "created": "2020-12-08T06:52:02.863Z", "modified": "2020-12-10T09:05:36.064Z"}, {"entity": "publication", "iuid": "7a56f791eb7449fda11f805ef6c6f22e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a56f791eb7449fda11f805ef6c6f22e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a56f791eb7449fda11f805ef6c6f22e"}}, "title": "Note from the editors: World Health Organization declares novel coronavirus (2019-nCoV) sixth public health emergency of international concern.", "authors": [], "type": "journal article", "published": "2020-02-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "5", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.5.200131e", "pmid": "32019636", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7014669"}], "notes": [], "created": "2020-12-08T06:50:47.542Z", "modified": "2020-12-10T09:07:14.293Z"}, {"entity": "publication", "iuid": "3f28068739f0480fb93dab85b6750c3c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f28068739f0480fb93dab85b6750c3c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f28068739f0480fb93dab85b6750c3c"}}, "title": "Latest updates on COVID-19 from the European Centre for Disease Prevention and Control.", "authors": [], "type": "journal article", "published": "2020-02-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "6", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.6.2002131", "pmid": "32070466", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7029450"}], "notes": [], "created": "2020-12-08T06:51:11.110Z", "modified": "2020-12-08T06:51:23.372Z"}, {"entity": "publication", "iuid": "8a6310427b8c4a0ea6204f8c69a060ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a6310427b8c4a0ea6204f8c69a060ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a6310427b8c4a0ea6204f8c69a060ef"}}, "title": "Latest assessment on COVID-19 from the European Centre for Disease Prevention and Control (ECDC).", "authors": [], "type": "journal article", "published": "2020-02-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "8", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.8.2002271", "pmid": "32127126", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7055041"}], "notes": [], "created": "2020-12-08T06:51:46.191Z", "modified": "2020-12-10T09:07:12.084Z"}, {"entity": "publication", "iuid": "4ddd8421feca423ca1949412569cae50", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ddd8421feca423ca1949412569cae50.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ddd8421feca423ca1949412569cae50"}}, "title": "Laboratory readiness and response for novel coronavirus (2019-nCoV) in expert laboratories in 30 EU/EEA countries, January 2020.", "authors": [{"family": "Reusken", "given": "Chantal B E M", "initials": "CBEM"}, {"family": "Broberg", "given": "Eeva K", "initials": "EK"}, {"family": "Haagmans", "given": "Bart", "initials": "B"}, {"family": "Meijer", "given": "Adam", "initials": "A"}, {"family": "Corman", "given": "Victor M", "initials": "VM"}, {"family": "Papa", "given": "Anna", "initials": "A"}, {"family": "Charrel", "given": "Remi", "initials": "R"}, {"family": "Drosten", "given": "Christian", "initials": "C"}, {"family": "Koopmans", "given": "Marion", "initials": "M"}, {"family": "Leitmeyer", "given": "Katrin", "initials": "K"}], "type": "journal article", "published": "2020-02-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "6", "issn-l": null}, "abstract": "Timely detection of novel coronavirus (2019-nCoV) infection cases is crucial to interrupt the spread of this virus. We assessed the required expertise and capacity for molecular detection of 2019-nCoV in specialised laboratories in 30 European Union/European Economic Area (EU/EEA) countries. Thirty-eight laboratories in 24 EU/EEA countries had diagnostic tests available by 29 January 2020. A coverage of all EU/EEA countries was expected by mid-February. Availability of primers/probes, positive controls and personnel were main implementation barriers.", "doi": "10.2807/1560-7917.ES.2020.25.6.2000082", "pmid": "32046815", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7029448"}], "notes": [], "created": "2020-12-10T09:07:15.398Z", "modified": "2020-12-10T09:07:15.407Z"}, {"entity": "publication", "iuid": "18a18e7be6c948a69430c431929b1c8c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18a18e7be6c948a69430c431929b1c8c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18a18e7be6c948a69430c431929b1c8c"}}, "title": "Evaluation of a COVID-19 IgM and IgG rapid test; an efficient tool for assessment of past exposure to SARS-CoV-2", "authors": [{"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Nissen", "given": "Karolina", "initials": "K"}, {"family": "Krambrich", "given": "Janina", "initials": "J"}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B"}, {"family": "Akaberi", "given": "Dario", "initials": "D"}, {"family": "Esmaeilzadeh", "given": "Mouna", "initials": "M"}, {"family": "Salaneck", "given": "Erik", "initials": "E"}, {"family": "Lindahl", "given": "Johanna", "initials": "J"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "journal-article", "published": "2020-01-01", "journal": {"title": "Infect Ecol Epidemiol", "issn": "2000-8686", "issn-l": "2000-8686", "volume": "10", "issue": "1", "pages": "1754538"}, "abstract": "COVID-19 is the most rapidly growing pandemic in modern time, and the need for serological testing is most urgent. Although the diagnostics of acute patients by RT-PCR is both efficient and specific, we are also crucially in need of serological tools for investigating antibody responses and assessing individual and potential herd immunity. We evaluated a commercially available test developed for rapid (within 15 minutes) detection of SARS-CoV-2-specific IgM and IgG by 29 PCR-confirmed COVID-19 cases and 124 negative controls. The results revealed a sensitivity of 69% and 93.1% for IgM and IgG, respectively, based solely on PCR-positivity due to the absence of a serological gold standard. The assay specificities were shown to be 100% for IgM and 99.2% for IgG. This indicates that the test is suitable for assessing previous virus exposure, although negative results may be unreliable during the first weeks after infection. More detailed studies on antibody responses during and post infection are urgently needed.", "doi": "10.1080/20008686.2020.1754538", "pmid": null, "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Imaging": null, "Category: Health": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-04T06:47:15.391Z", "modified": "2021-02-26T08:46:12.946Z"}, {"entity": "publication", "iuid": "835438bc55a64fd2bab901dcb8287ac4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/835438bc55a64fd2bab901dcb8287ac4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/835438bc55a64fd2bab901dcb8287ac4"}}, "title": "Note from the editors: novel coronavirus (2019-nCoV).", "authors": [{"family": "Eurosurveillance editorial team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-01-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "3", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.3.2001231", "pmid": "31992390", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC6988271"}], "notes": [], "created": "2020-12-10T09:07:13.182Z", "modified": "2020-12-10T09:07:13.192Z"}, {"entity": "publication", "iuid": "276c7b56c9bc482782475182bd6bf288", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/276c7b56c9bc482782475182bd6bf288.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/276c7b56c9bc482782475182bd6bf288"}}, "title": "Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS-CoV-2 in an ageing population, consider N-acetylcysteine as early therapeutic intervention", "authors": [{"family": "Nasi", "given": "Aikaterini", "initials": "A", "orcid": "0000-0002-9935-1008", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42e476f1362242ee934f3f2d29c01647.json"}}, {"family": "McArdle", "given": "Stephanie", "initials": "S", "orcid": "0000-0001-6929-9782", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2f69bf332d74e7f814bc12f53c4bca1.json"}}, {"family": "Gaudernack", "given": "Gustav", "initials": "G"}, {"family": "Westman", "given": "Gabriel", "initials": "G"}, {"family": "Melief", "given": "Cornelis", "initials": "C"}, {"family": "Rockberg", "given": "Johan", "initials": "J"}, {"family": "Arens", "given": "Ramon", "initials": "R", "orcid": "0000-0001-5058-4110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/440c6baa3803427fbd9001dfa4725247.json"}}, {"family": "Kouretas", "given": "Demetrios", "initials": "D"}, {"family": "Sj\u00f6lin", "given": "Jan", "initials": "J"}, {"family": "Mangsbo", "given": "Sara", "initials": "S", "orcid": "0000-0002-1355-2678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cf494629d8a4f9584ada4be16dff66b.json"}}], "type": "journal-article", "published": "2020-00-00", "journal": {"title": "Toxicology Reports", "issn": "2214-7500", "issn-l": "2214-7500", "volume": "7", "issue": null, "pages": "768-771"}, "abstract": "During the current COVID-19 pandemic, a need for evaluation of already available drugs for treatment of the disease is crucial. Hereby, based on literature review from the current pandemic and previous outbreaks with corona viruses we analyze the impact of the virus infection on cell stress responses and redox balance. High levels of mortality are noticed in elderly individuals infected with SARS-CoV2 and during the previous SARS-CoV1 outbreak. Elderly individuals maintain a chronic low level of inflammation which is associated with oxidative stress and inflammatory cytokine production, a condition that increases the severity of viral infections in this population. Coronavirus infections can lead to alterations of redox balance in infected cells through modulation of NAD + biosynthesis, PARP function along with altering proteasome and mitochondrial function in the cell thereby leading to enhanced cell stress responses which further exacerbate inflammation. ROS production can increase IL-6 production and lipid peroxidation resulting in cell damage. Therefore, early treatment with anti-oxidants such as NAC during COVID-19 can be a way to bypass the excessive inflammation and cell damage that lead to severe infection, thus early NAC as intervention should be evaluated in a clinical trial setting.", "doi": "10.1016/j.toxrep.2020.06.003", "pmid": "32632359", "labels": {"Funder: KAW/SciLifeLab": null, "Type: Review": null, "Research Area: Drug discovery and repurposing of drugs": null}, "xrefs": [{"db": "pii", "key": "S2214-7500(20)30336-X"}, {"db": "pmc", "key": "PMC7301821"}], "notes": [], "created": "2020-11-04T07:09:44.267Z", "modified": "2022-02-06T17:39:19.668Z"}, {"entity": "publication", "iuid": "2ecd356aee194db0b6de668cf27aac00", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ecd356aee194db0b6de668cf27aac00.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ecd356aee194db0b6de668cf27aac00"}}, "title": "Principles of mental health care during the COVID-19 pandemic", "authors": [{"family": "Kuzman", "given": "Martina Rojnic", "initials": "MR", "orcid": "0000-0001-9646-0594", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fad1012ef6d4d528af166ab01e06c9d.json"}}, {"family": "Curkovic", "given": "Marko", "initials": "M", "orcid": "0000-0002-4855-2133", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29ca35067e324a22839263700264ecab.json"}}, {"family": "Wasserman", "given": "Danuta", "initials": "D"}], "type": "journal-article", "published": "2020-00-00", "journal": {"title": "Eur Psychiatry", "issn": "0924-9338", "volume": "63", "issue": "1", "pages": "e45", "issn-l": null}, "abstract": "We describe the basic principles of mental health care during the COVID-19 pandemic that should be endorsed by the mental health professional associations and incorporated in the health strategies for the management of the COVID-19 pandemic. The main principle is that there should be no substantial differences in the provision of health care for COVID-19 between persons with pre-existing mental health disorders and the ones without previous disorders. Subsequently, the organization of the health care should reflect that as well. These principles should (a) prevent the possible effects of stigmatizing attitudes toward mental health issues, possibly leading to potentially deleterious situations, such as psychiatric patients being treated (even temporarily) separately from other patients, in psychiatric facilities, where the staff is not equipped and trained adequately for the management of COVID-19; (b) highlight the fact that patients with mental health disorders are at greater risk for developing serious complications of COVID-19 infection due to other factors-they often smoke and have comorbidities such as hypertension, diabetes, all associated with higher morbidity and mortality from COVID-19 infection; (c) highlight that measures should be taken to minimize the risk of the spread of infection in psychiatric wards/institutions; (d) provide a general framework for the reorganization of mental health services toward the provision of services for persons in need, including frontline medical workers and patients with COVID-19 without previous mental health problems as well as for persons with pre-existing mental health problems under new circumstances of pandemic.", "doi": "10.1192/j.eurpsy.2020.54", "pmid": "32431255", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0924933820000541"}, {"db": "pmc", "key": "PMC7267055"}], "notes": [], "created": "2020-11-25T09:08:56.007Z", "modified": "2021-12-06T13:17:17.161Z"}, {"entity": "publication", "iuid": "2255c0c2ec314e95ab1e0d30d475f231", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2255c0c2ec314e95ab1e0d30d475f231.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2255c0c2ec314e95ab1e0d30d475f231"}}, "title": "COVID-19: A case report from Bangladesh perspective", "authors": [{"family": "Jahan", "given": "Yasmin", "initials": "Y"}, {"family": "Rahman", "given": "Sohel", "initials": "S"}, {"family": "Rahman", "given": "Atiqur", "initials": "A"}], "type": "journal-article", "published": "2020-00-00", "journal": {"title": "Respir Med Case Rep", "issn": "2213-0071", "volume": "30", "issue": null, "pages": "101068", "issn-l": null}, "abstract": "A 34-year-old man without any significant medical history or comorbidities, suddenly developed fever, and shortness of breath, thereby admitted to the emergency department of a tertiary care hospital, Dhaka, Bangladesh. He had neither a history of traveling to Coronavirus disease (COVID) prone areas nor a direct contact of COVID positive patients. His chest X-ray revealed ground-glass opacity in the right middle and lower zone of the lung. The first polymerase chain reaction (PCR) test on throat and nasal swabs for the COVID upon admission was negative. Based on the chest X-ray result, RT-PCR was done again resulted positive. The patient was primarily treated with chloroquine and azithromycin. On full recovery, he was discharged from the hospital on day 12, after two subsequent throat swab samples tested negative by PCR (24 hours apart). He was encouraged to maintain home quarantine for at least the next 14 days. SARS-CoV-2 RNA by swab remained negative and the blood sample shows the presence of antibody (both IgM and IgG) in his follow-up visit (after 7 days of hospital discharge).", "doi": "10.1016/j.rmcr.2020.101068", "pmid": "32363143", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7194830"}, {"db": "pii", "key": "S2213-0071(20)30173-8"}, {"db": "pii", "key": "101068"}], "notes": [], "created": "2020-12-10T07:25:21.814Z", "modified": "2021-12-06T12:57:00.418Z"}]}
\ No newline at end of file
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+++ b/data/publications_old.json
@@ -0,0 +1 @@
+{"entity": "publications", "timestamp": "2023-11-02T14:41:19.846Z", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publications.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publications"}}, "publications_count": 3405, "full": true, "publications": [{"entity": "publication", "iuid": "a5a5288d35b84c81a7211dc46aa3f8f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a5a5288d35b84c81a7211dc46aa3f8f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a5a5288d35b84c81a7211dc46aa3f8f9"}}, "title": "Confidence in COVID-19 vaccine effectiveness and safety and its effect on vaccine uptake in Tanzania: A community-based cross-sectional study.", "authors": [{"family": "Mtei", "given": "Monica", "initials": "M", "orcid": "0000-0002-0407-6593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0880cf78afbb447e9af763d5fcc063b6.json"}}, {"family": "Mboya", "given": "Innocent B", "initials": "IB"}, {"family": "Mgongo", "given": "Melina", "initials": "M"}, {"family": "Manongi", "given": "Rachel", "initials": "R"}, {"family": "Amour", "given": "Caroline", "initials": "C"}, {"family": "Bilakwate", "given": "Julieth S", "initials": "JS"}, {"family": "Nyaki", "given": "Ahmed Y", "initials": "AY"}, {"family": "Ngocho", "given": "James", "initials": "J"}, {"family": "Jonas", "given": "Norman", "initials": "N"}, {"family": "Farah", "given": "Amina", "initials": "A"}, {"family": "Amour", "given": "Maryam", "initials": "M"}, {"family": "Kalolo", "given": "Albino", "initials": "A"}, {"family": "Kengia", "given": "James T", "initials": "JT"}, {"family": "Tinuga", "given": "Florian", "initials": "F"}, {"family": "Ngalesoni", "given": "Frida", "initials": "F"}, {"family": "Bakari", "given": "Abdalla H", "initials": "AH"}, {"family": "Kirakoya", "given": "Fatimata B", "initials": "FB"}, {"family": "Araya", "given": "Awet", "initials": "A"}, {"family": "Kapologwe", "given": "Ntuli A", "initials": "NA"}, {"family": "Msuya", "given": "Sia E", "initials": "SE"}], "type": "journal article", "published": "2023-12-31", "journal": {"title": "Hum Vaccin Immunother", "issn": "2164-554X", "volume": "19", "issue": "1", "pages": "2191576", "issn-l": null}, "abstract": "COVID-19 is a major public health threat associated with increased disease burden, mortality, and economic loss to countries and communities. Safe and efficacious COVID-19 vaccines are key in halting and reversing the pandemic. Low confidence in vaccines has been one of the factors leading to hesitancy. We aimed to assess the COVID-19 vaccine confidence (safety and effectiveness), associated factors, and its effects on vaccine uptake among general community members in Tanzania. This was a community-based cross-sectional survey conducted from December 2021 to April 2022 in six regions of Tanzania mainland and two regions in Zanzibar. Participants were interviewed using an electronic questionnaire. Multiple logistic regression models estimated odds ratios (ORs) and 95% confidence interval (CI) for factors associated with vaccine confidence. All analyses were performed using SPSS version 25.0. The study enrolled 3470 general Tanzanian community members; their mean age was 40.3 (standard deviation \u00b114.9) years, and 34% were males. The proportion of COVID-19 vaccine confidence was 54.6%. Geographical region, residence area, COVID-19 disease risk perception, and good knowledge of COVID-19 vaccines were significantly associated with COVID-19 vaccine confidence. Confidence in COVID-19 vaccines was associated with over three times higher odds of vaccine uptake. Confidence in COVID-19 vaccines was low in Tanzania. Innovative community engagement strategies and region-specific interventions are needed to improve comprehensive knowledge and address community perceptions and attitudes toward COVID-19 vaccines.", "doi": "10.1080/21645515.2023.2191576", "pmid": "37017234", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10088920"}], "notes": [], "created": "2023-04-20T17:33:21.814Z", "modified": "2023-04-20T17:33:21.864Z"}, {"entity": "publication", "iuid": "e51c2b2f8cfd4821b00b9ade72030dce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e51c2b2f8cfd4821b00b9ade72030dce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e51c2b2f8cfd4821b00b9ade72030dce"}}, "title": "The influence of the Covid-19 pandemic on municipal meeting places arranging group exercise for older persons.", "authors": [{"family": "Dinse", "given": "Daniella", "initials": "D", "orcid": "0000-0002-4756-6728", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4aaa7aafbba646a39fabc6bb5c708549.json"}}, {"family": "Haak", "given": "Maria", "initials": "M", "orcid": "0000-0002-0054-2542", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b94642fc4c14e8991de97ae05cf49dc.json"}}, {"family": "Nilsson", "given": "Marie", "initials": "M", "orcid": "0000-0003-2762-7041", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6065be7342ee4a0786a7eb5ef9ed074c.json"}}, {"family": "Karlsson", "given": "Staffan", "initials": "S", "orcid": "0000-0002-6624-9963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e647df4e8b2455e939b74098c4a63c3.json"}}, {"family": "Olsson M\u00f6ller", "given": "Ulrika", "initials": "U", "orcid": "0000-0002-6879-9563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62ee4ccae36d4217a611c09fbfcea041.json"}}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Int J Qual Stud Health Well-being", "issn": "1748-2631", "issn-l": null, "volume": "18", "issue": "1", "pages": "2235130"}, "abstract": "Many municipalities today, together with other stakeholders, offer group exercises for the older population via municipal meeting places, focusing on promoting good health. During the Covid-19 pandemic, these group exercises either continued in a modified form or ceased. The aim of this study was to explore involved stakeholders' experiences of group exercises for older persons arranged via municipal meeting places during the Covid-19 pandemic.\r\n\r\nSix online focus group interviews were conducted with 25 stakeholders, such as decision-makers and representatives from the non-profit sector, from seven municipalities in Sweden. Data were analysed using thematic analysis.\r\n\r\nThe collaboration around the group exercises was challenged due to affected communication and decision-making. The stakeholders described the importance of adapting and finding new ways to offer group exercise. Furthermore, the re-arranging of group exercises created concerns about the well-being of the older persons but also happiness with the older persons ability to act for their own well-being during the pandemic.\r\n\r\nThis study highlights the importance of the municipalities exchanging experiences, making the older persons more involved in the decision-making process, enabling a person-centred encounter with the older persons when exercising in groups, and strengthening supportive environments by sharing the ownership of arranging the group exercises with the older persons.", "doi": "10.1080/17482631.2023.2235130", "pmid": "37499132", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10375932"}], "notes": [], "created": "2023-10-04T12:08:42.317Z", "modified": "2023-10-04T12:39:04.249Z"}, {"entity": "publication", "iuid": "2c7332149f534505b1cd8b604e924b12", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c7332149f534505b1cd8b604e924b12.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c7332149f534505b1cd8b604e924b12"}}, "title": "The experiences of patients ill with COVID-19-like symptoms and the role of testing for SARS-CoV-2 in supporting them: A qualitative study in eight European countries during the first wave of the pandemic.", "authors": [{"family": "Hoste", "given": "Melanie E", "initials": "ME", "orcid": "0000-0003-0831-3354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2e7d9961a0d486db33addd840a2f827.json"}}, {"family": "Wanat", "given": "Marta", "initials": "M"}, {"family": "Gobat", "given": "Nina", "initials": "N"}, {"family": "Anastasaki", "given": "Marilena", "initials": "M"}, {"family": "B\u00f6hmer", "given": "Femke", "initials": "F"}, {"family": "Chlabicz", "given": "S\u0142awomir", "initials": "S"}, {"family": "Colliers", "given": "Annelies", "initials": "A", "orcid": "0000-0003-4960-2355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/da75d309875249ab927e572db2b3ec91.json"}}, {"family": "Farrell", "given": "Karen", "initials": "K"}, {"family": "Karkana", "given": "Maria-Nefeli", "initials": "M"}, {"family": "Kinsman", "given": "John", "initials": "J"}, {"family": "Lionis", "given": "Christos", "initials": "C", "orcid": "0000-0002-9324-2839", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4f78c9751aa4b288a80e6dd903f3f56.json"}}, {"family": "Marcinowicz", "given": "Ludmila", "initials": "L"}, {"family": "Reinhardt", "given": "Katrin", "initials": "K"}, {"family": "Skoglund", "given": "Ingmarie", "initials": "I"}, {"family": "Sundvall", "given": "P\u00e4r-Daniel", "initials": "P"}, {"family": "Vellinga", "given": "Akke", "initials": "A", "orcid": "0000-0002-6583-4300", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84b752b8202048bca41ca262b5536985.json"}}, {"family": "Goossens", "given": "Herman", "initials": "H"}, {"family": "Butler", "given": "Christopher C", "initials": "CC"}, {"family": "van der Velden", "given": "Alike", "initials": "A"}, {"family": "Tonkin-Crine", "given": "Sarah", "initials": "S"}, {"family": "Anthierens", "given": "Sibyl", "initials": "S"}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Eur J Gen Pract", "issn": "1751-1402", "issn-l": null, "volume": "29", "issue": "2", "pages": "2212904"}, "abstract": "Access to testing during the first wave of the COVID-19 pandemic was limited, impacting patients with COVID-19-like symptoms. Current qualitative studies have been limited to one country or were conducted outside Europe.\r\n\r\nTo explore - in eight European countries - the experiences of patients consulting in primary care with COVID-19-like symptoms during the first wave of the pandemic.\r\n\r\nSixty-six semi-structured interviews, informed by a topic guide, were conducted by telephone or in person between April and July 2020. Patients with COVID-19-like symptoms were purposively recruited in primary care sites in eight countries and sampled based on age, gender, and symptom presentation. Deductive and inductive thematic analysis techniques were used to develop a framework representing data across settings. Data adequacy was attained by collecting rich data.\r\n\r\nSeven themes were identified, which described the experiences of patients consulting. Two themes are reported in this manuscript describing the role of COVID-19 testing in this experience. Patients described significant distress due to their symptoms, especially those at higher risk of complications from COVID-19, and those with severe symptoms. Patients wanted access to testing to identify the cause of their illness and minimise the burden of managing uncertainty. Some patients testing positive for COVID-19 assumed they would be immune from future infection.\r\n\r\nPatients experiencing novel and severe symptoms, particularly those with comorbidities, experienced a significant emotional and psychological burden due to concerns about COVID-19. Testing provided reassurance over health status and helped patients identify which guidance to follow. Testing positive for SARS-CoV-2 led to some patients thinking they were immune from future infection, thus influencing subsequent behaviour.", "doi": "10.1080/13814788.2023.2212904", "pmid": "37248990", "labels": {"Category: Social Science & Humanities": null, "Funder: H2020": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10249444"}], "notes": [], "created": "2023-10-04T05:08:51.674Z", "modified": "2023-10-04T05:30:49.922Z"}, {"entity": "publication", "iuid": "5479327ce61d4dd39f99c46c502b7f4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5479327ce61d4dd39f99c46c502b7f4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5479327ce61d4dd39f99c46c502b7f4c"}}, "title": "The distorted memories of patients treated in the intensive care unit during the COVID-19 pandemic: A qualitative study.", "authors": [{"family": "Vogel", "given": "Gisela", "initials": "G"}, {"family": "Forinder", "given": "Ulla", "initials": "U"}, {"family": "Sandgren", "given": "Anna", "initials": "A"}, {"family": "Svensen", "given": "Christer", "initials": "C"}, {"family": "Joelsson-Alm", "given": "Eva", "initials": "E"}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "issn-l": null, "volume": "79", "issue": null, "pages": "103522"}, "abstract": "During the COVID-19 pandemic, patients cared for in the intensive care unit were exposed to many risk factors for developing delirium and subsequent distorted memories. Further, seeing healthcare professionals who have been dressed in personal protective equipment and face masks could have affected the patients' memories. Therefore, the aim of this study was to explore memories and how they are experienced and managed by former patients who have been treated for COVID-19 in an intensive care unit.\r\n\r\nSixteen former patients treated for COVID-19 at a large emergency hospital in Sweden were interviewed 3-8 months after discharge from the intensive care unit. The data were interpreted using thematic analysis. The Consolidated Criteria for Reporting Qualitative Research checklist was followed in the reporting of the study.\r\n\r\nParticipants' descriptions of their memories of treatment in the intensive care unit for COVID-19 generated three themes: 'Distorted truth' the content in the memories which implied facing death in an unreal distorted environment. 'Captive,' was the experience and feelings linked to memories with a feeling of being exposed and alone, and 'Coping with memories' explained how participants managed the implications of the memories using a mixture of strategies.\r\n\r\nFor former patients who were admitted to an intensive care unit after a diagnosis of COVID-19, memories caused considerable distress, which were similar to other intensive care patient\u015b experiences, before the pandemic. Emotion-focused and problem-focused strategies could be used to cope with these memories. Healthcare professionals wearing protective equipment gave the patient a distant feeling, but more important was to be treated with attention/care and respect.\r\n\r\nAwareness of the impact of distorted memories on patients who are severely ill and their needs and strategies to cope with these memories can form the basis for early interventions that promotes well-being during care and recovery. Healthcare professionals have an important task to inform patients and their family members about the existence of distorted memories, and talk about the patients' experience of them, to facilitate their recovery.", "doi": "10.1016/j.iccn.2023.103522", "pmid": "37598502", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(23)00139-8"}], "notes": [], "created": "2023-10-05T08:08:44.568Z", "modified": "2023-10-06T04:33:26.762Z"}, {"entity": "publication", "iuid": "df1add79ba144dcc955eab39d23f0571", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/df1add79ba144dcc955eab39d23f0571.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/df1add79ba144dcc955eab39d23f0571"}}, "title": "Tailored internet-based psychological treatment for psychological problems during the COVID-19 pandemic: A randomized controlled trial.", "authors": [{"family": "Aminoff", "given": "Victoria", "initials": "V"}, {"family": "Bobeck", "given": "Johanna", "initials": "J"}, {"family": "Hjort", "given": "Sofia", "initials": "S"}, {"family": "S\u00f6rliden", "given": "Elise", "initials": "E"}, {"family": "Ludvigsson", "given": "Mikael", "initials": "M"}, {"family": "Berg", "given": "Matilda", "initials": "M"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Internet Interv", "issn": "2214-7829", "issn-l": "2214-7829", "volume": "34", "issue": null, "pages": "100662"}, "abstract": "The COVID-19 pandemic influence mental health in both infected and non-infected populations. In this study we examined if individually tailored internet-based cognitive behavioral therapy (ICBT) could be an effective treatment for psychological symptoms related to the pandemic. Following recruitment we included 76 participants who were randomized to either a treatment group (n = 37) or a waitlist control group (n = 39). The treatment group received 8 modules (out of 16 possible) during 8 weeks with weekly therapist support. We collected data on symptoms of depression, experienced quality of life, anxiety, stress, anger, insomnia, PTSD, and alcohol use before, after the treatment and at one year follow-up. Using multiple regression analysis, group condition was found to be a statistically significant predictor for a decrease, favoring the treatment group, in symptoms of depression, insomnia, and anger with small to moderate effect sizes. The improvements remained at one year follow-up. Group condition did not significantly predict changing symptoms regarding experienced quality of life, anxiety, stress, PTSD and alcohol use. Findings indicate that ICBT is an effective intervention for some psychological symptoms associated with the COVID-19 pandemic. There is a need for further studies on mechanisms of change and on tailored ICBT for problems associated with crises like the pandemic.", "doi": "10.1016/j.invent.2023.100662", "pmid": "37671335", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10475474"}, {"db": "pii", "key": "S2214-7829(23)00062-3"}], "notes": [], "created": "2023-10-06T06:56:36.372Z", "modified": "2023-10-06T11:19:54.405Z"}, {"entity": "publication", "iuid": "d8627c522c93438bab63f8c22c362e8c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d8627c522c93438bab63f8c22c362e8c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d8627c522c93438bab63f8c22c362e8c"}}, "title": "Public health restrictions, directives, and measures in Arctic countries in the first year of the COVID-19 pandemic.", "authors": [{"family": "Peterson", "given": "Malory", "initials": "M", "orcid": "0000-0001-9730-899X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/535cfc55eb4245238a543ceae4955aa0.json"}}, {"family": "Akearok", "given": "Gwen Healey", "initials": "GH", "orcid": "0000-0001-9507-2610", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d74acdff0470400cb32d8790f4c44c6a.json"}}, {"family": "Cueva", "given": "Katie", "initials": "K", "orcid": "0000-0002-8013-9680", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d904d970c544a9fb4a51aa0b54a3d07.json"}}, {"family": "Lavoie", "given": "Jos\u00e9e G", "initials": "JG", "orcid": "0000-0003-2483-431X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/979bb18295514ce28f361f6479080b98.json"}}, {"family": "Larsen", "given": "Christina Vl", "initials": "CV", "orcid": "0000-0002-6245-4222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/122c1ea2512947258ee6e0b3c727651e.json"}}, {"family": "J\u00f3hannsd\u00f3ttir", "given": "L\u00e1ra", "initials": "L", "orcid": "0000-0001-5912-3337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6cd00a909ab4a7fae2beb9765eaa4b6.json"}}, {"family": "Cook", "given": "David", "initials": "D", "orcid": "0000-0001-9200-0515", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0e0ad34240445e78514fd55ce6e76fa.json"}}, {"family": "Nilsson", "given": "Lena Maria", "initials": "LM", "orcid": "0000-0002-2354-7258", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1dc6f1b33370474f9ad51f370d9cf3c3.json"}}, {"family": "Rautio", "given": "Arja", "initials": "A", "orcid": "0000-0002-5816-533X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07a185cd1ef3427b9f49847cbd268617.json"}}, {"family": "Timlin", "given": "Ulla", "initials": "U", "orcid": "0000-0002-7840-4430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a0fcd3b9cb94ca58b719ed94812c719.json"}}, {"family": "San Sebasti\u00e1n", "given": "Miguel", "initials": "M", "orcid": "0000-0001-7234-3510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e7ccb93844f4bd6aba400b70261d37b.json"}}, {"family": "Gladun", "given": "Elena", "initials": "E", "orcid": "0000-0003-2525-6638", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/180f54a51ddc4c3ca988012e0c98a604.json"}}, {"family": "Rink", "given": "Elizabeth", "initials": "E", "orcid": "0000-0002-5738-5496", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5578d7332c574ea4988f8d94a988138b.json"}}, {"family": "Broderstadt", "given": "Ann Ragnhild", "initials": "AR", "orcid": "0000-0003-3843-6953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4de647a328304fd0be8fd6f308758d48.json"}}, {"family": "Dagsvold", "given": "Inger", "initials": "I"}, {"family": "Siri", "given": "Susanna", "initials": "S", "orcid": "0000-0003-3231-8139", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fa098be57c24667a8e4ffa526d1f12f.json"}}, {"family": "Ottendahl", "given": "Charlotte Brandstrup", "initials": "CB", "orcid": "0000-0002-9285-3099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c6f92de274540a0b3ad587252e69425.json"}}, {"family": "Olesen", "given": "Ingelise", "initials": "I"}, {"family": "Zatseva", "given": "Larisa", "initials": "L"}, {"family": "Young", "given": "Rebecca Ipiaqruk", "initials": "RI", "orcid": "0009-0009-3502-1147", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db8a63fdb6f84bf6875a32f57a066840.json"}}, {"family": "Chaliak", "given": "Ay'aqulluk Jim", "initials": "AJ", "orcid": "0009-0003-0559-0871", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba18ca8951c14fbba3f58123107f15ba.json"}}, {"family": "Ophus", "given": "Emily", "initials": "E"}, {"family": "Stoor", "given": "Jon Petter A", "initials": "JPA", "orcid": "0000-0002-1580-8307", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61077580fa204d84ada7e7cdc395dadc.json"}}], "type": "review", "published": "2023-12-00", "journal": {"title": "Int J Circumpolar Health", "issn": "2242-3982", "issn-l": null, "volume": "82", "issue": "1", "pages": "2271211"}, "abstract": "Beginning January of 2020, COVID-19 cases detected in Arctic countries triggered government policy responses to stop transmission and limit caseloads beneath levels that would overwhelm existing healthcare systems. This review details the various restrictions, health mandates, and transmission mitigation strategies imposed by governments in eight Arctic countries (the United States, Canada, Greenland, Norway, Finland, Sweden, Iceland, and Russia) during the first year of the COVID-19 pandemic, through 31 January 2021s31 January 2021. We highlight formal protocols and informal initiatives adopted by local communities in each country, beyond what was mandated by regional or national governments. This review documents travel restrictions, communications, testing strategies, and use of health technology to track and monitor COVID-19 cases. We provide geographical and sociocultural background and draw on local media and communications to contextualise the impact of COVID-19 emergence and prevention measures in Indigenous communities in the Arctic. Countries saw varied case rates associated with local protocols, governance, and population. Still, almost all regions maintained low COVID-19 case rates until November of 2020. This review was produced as part of an international collaboration to identify community-driven, evidence-based promising practices and recommendations to inform pan-Arctic collaboration and decision making in public health during global emergencies.", "doi": "10.1080/22423982.2023.2271211", "pmid": "37898999", "labels": {"Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:32:19.806Z", "modified": "2023-11-02T07:01:24.967Z"}, {"entity": "publication", "iuid": "b884f27250514663a9b65039859959f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b884f27250514663a9b65039859959f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b884f27250514663a9b65039859959f7"}}, "title": "Prevalence and factors associated with healthcare avoidance during the COVID-19 pandemic among the S\u00e1mi in Sweden: the S\u00e1miHET study.", "authors": [{"family": "Dresse", "given": "Menayit Tamrat", "initials": "MT", "orcid": "0000-0003-4830-8242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/16cf2e49e4234a4294b5b9ab46f57487.json"}}, {"family": "Stoor", "given": "Jon Petter", "initials": "JP", "orcid": "0000-0002-1580-8307", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61077580fa204d84ada7e7cdc395dadc.json"}}, {"family": "San Sebastian", "given": "Miguel", "initials": "M", "orcid": "0000-0001-7234-3510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e7ccb93844f4bd6aba400b70261d37b.json"}}, {"family": "Nilsson", "given": "Lena Maria", "initials": "LM", "orcid": "0000-0002-2354-7258", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1dc6f1b33370474f9ad51f370d9cf3c3.json"}}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Int J Circumpolar Health", "issn": "2242-3982", "issn-l": null, "volume": "82", "issue": "1", "pages": "2213909"}, "abstract": "The aim of this population-based cross-sectional study was to assess the prevalence of healthcare avoidance during the COVID-19 pandemic and its associated factors among the S\u00e1mi population in Sweden. Data from the \"S\u00e1mi Health on Equal Terms\" (S\u00e1miHET) survey conducted in 2021 were used. Overall, 3,658 individuals constituted the analytical sample. Analysis was framed using the social determinants of health framework. The association between healthcare avoidance and several sociodemographic, material, and cultural factors was explored through log-binomial regression analyses. Sampling weights were applied in all analyses. Thirty percent of the S\u00e1mi in Sweden avoided healthcare during the COVID-19 pandemic. S\u00e1mi women (PR: 1.52, 95% CI: 1.36-1.70), young adults (PR: 1.22, 95% CI:1.05-1.47), S\u00e1mi living outside S\u00e1pmi (PR: 1.17, 95% CI: 1.03-1.34), and those having low income (PR: 1.42, 95% CI:1.19-1.68) and experiencing economic stress (PR: 1.48, 95% CI: 1.31-1.67) had a higher prevalence of healthcare avoidance. The pattern shown in this study can be useful for planning future pandemic responses, which should address healthcare avoidance, particularly among the identified vulnerable groups, including the active participation of the S\u00e1mi themselves.", "doi": "10.1080/22423982.2023.2213909", "pmid": "37216571", "labels": {"Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10208175"}], "notes": [], "created": "2023-10-04T05:09:51.425Z", "modified": "2023-10-04T06:18:54.180Z"}, {"entity": "publication", "iuid": "4b91c5e8663548b2a09a41385d1c5d92", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b91c5e8663548b2a09a41385d1c5d92.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b91c5e8663548b2a09a41385d1c5d92"}}, "title": "Low-intensity online mindfulness-based intervention for university students with anxiety during the COVID-19 pandemic-A randomized controlled trial with 3-month follow-up.", "authors": [{"family": "Young", "given": "Daniel Kim-Wan", "initials": "DK"}, {"family": "Carlbring", "given": "Per", "initials": "P"}, {"family": "Ng", "given": "Petrus Yat-Nam", "initials": "PY"}, {"family": "Cheng", "given": "Daphne Yi Ting", "initials": "DYT"}, {"family": "Chen", "given": "Joseph Qi-Rong", "initials": "JQ"}, {"family": "Ng", "given": "Siu-Man", "initials": "S"}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Internet Interv", "issn": "2214-7829", "issn-l": "2214-7829", "volume": "34", "issue": null, "pages": "100665"}, "abstract": "This study investigated the effectiveness of a low-intensity online mindfulness-based Intervention (iMBI) for alleviating anxiety in university students during the COVID-19 pandemic.\r\n\r\nIn a randomized controlled trial involving 134 participants from a local university in Hong Kong, subjects were randomly assigned to either the intervention group (n = 67) or the inactive control group (n = 67). The intervention group participated in a low-intensity iMBI comprising 16 online modules and two half-day online mindfulness workshops over an eight-week period. Outcomes were measured via an online platform using standardized assessment scales, including the Beck Anxiety Inventory and the Chinese Five Facets Mindfulness Questionnaire, at three different time points: pre-intervention, post-intervention and at a three-month follow-up.\r\n\r\nIntent-to-treat analysis using 2 (group) \u00d7 3 (time) repeated measures of covariance (ANCOVA) showed that the intervention group, compared to the control group, showed a significant reduction in anxiety symptoms with a medium effect size (Cohen's d = 0.5) and a significant improvement in mindfulness skills with a medium effect size (Cohen's d = 0.5) at post-intervention. The effects of the intervention in reducing anxiety and improving mindfulness persisted at the three-month follow-up.\r\n\r\nThe results of this study demonstrate the effectiveness of the low-intensity iMBI in alleviating anxiety among university students.", "doi": "10.1016/j.invent.2023.100665", "pmid": "37840645", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10569980"}, {"db": "pii", "key": "S2214-7829(23)00065-9"}], "notes": [], "created": "2023-11-01T13:34:14.816Z", "modified": "2023-11-02T07:44:47.549Z"}, {"entity": "publication", "iuid": "a7f18fab206d4d86aa561ea378cbcee3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7f18fab206d4d86aa561ea378cbcee3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7f18fab206d4d86aa561ea378cbcee3"}}, "title": "Effects of fine particulate matter (PM2.5) and meteorological factors on the daily confirmed cases of COVID-19 in Bangkok during 2020\u20132021, Thailand", "authors": [{"family": "Sangkham", "given": "Sarawut", "initials": "S", "orcid": "0000-0002-0507-0177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/156042be10a148acbf5fddef6e7b3b6f.json"}}, {"family": "Islam", "given": "Md Aminul", "initials": "MA"}, {"family": "Sarndhong", "given": "Kritsada", "initials": "K"}, {"family": "Vongruang", "given": "Patipat", "initials": "P"}, {"family": "Hasan", "given": "Mohammad Nayeem", "initials": "MN"}, {"family": "Tiwari", "given": "Ananda", "initials": "A"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}], "type": "journal-article", "published": "2023-12-00", "journal": {"title": "Case Studies in Chemical and Environmental Engineering", "issn": "2666-0164", "issn-l": null, "volume": "8", "issue": null, "pages": "100410"}, "abstract": null, "doi": "10.1016/j.cscee.2023.100410", "pmid": null, "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:33:28.320Z", "modified": "2023-10-04T09:41:09.413Z"}, {"entity": "publication", "iuid": "f95d3431743140bd81bff9689e633b9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f95d3431743140bd81bff9689e633b9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f95d3431743140bd81bff9689e633b9c"}}, "title": "Adolescents' and young people's experiences of social relationships and health concerns during COVID-19.", "authors": [{"family": "Sundler", "given": "Annelie J", "initials": "AJ", "orcid": "0000-0002-9194-3244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7308e89c2f4840268add7c61d26e3fbb.json"}}, {"family": "Bergnehr", "given": "Disa", "initials": "D", "orcid": "0000-0002-6357-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/524674f9584741db8884173f5a79cad3.json"}}, {"family": "Haffejee", "given": "Sadiyya", "initials": "S", "orcid": "0000-0002-9513-6861", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adb65c4ef1ee434caf5e5d7072480208.json"}}, {"family": "Iqbal", "given": "Humera", "initials": "H", "orcid": "0000-0002-3437-3759", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5185c706da4645b2b876109b656311f1.json"}}, {"family": "Orellana", "given": "Marjorie Faulstich", "initials": "MF", "orcid": "0000-0003-2921-5892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33c2dafbb15e4ba4857a757eda516d56.json"}}, {"family": "Vergara Del Solar", "given": "Ana", "initials": "A", "orcid": "0000-0001-7823-3769", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6af89e09de6e455885fffab8c124d47b.json"}}, {"family": "Angeles", "given": "Sophia L", "initials": "SL", "orcid": "0000-0003-1407-2753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc7a158043034ea48799125447ef5dfd.json"}}, {"family": "Faircloth", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-2919-2814", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ac7f62100114af098aee4e7e914c5ef.json"}}, {"family": "Liu", "given": "Lu", "initials": "L", "orcid": "0000-0003-2101-4586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88b3fd92889a4da58f1f77857c4db6ff.json"}}, {"family": "Mwanda", "given": "Anita", "initials": "A", "orcid": "0000-0001-8161-0000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f796590cf01b494f80336fd93d14b87a.json"}}, {"family": "Sep\u00falveda Galeas", "given": "Mauricio", "initials": "M", "orcid": "0000-0002-0736-6596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a5aa9dfad67421fae144dc866e9f1e2.json"}}, {"family": "Simelane", "given": "Thandi", "initials": "T", "orcid": "0000-0001-9906-1820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8443cdc6041c4a7ba103d8413c810b78.json"}}, {"family": "Twamley", "given": "Katherine", "initials": "K", "orcid": "0000-0001-8701-7427", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a090cb6978b14bebb226e224a6347c1b.json"}}, {"family": "Darcy", "given": "Laura", "initials": "L", "orcid": "0000-0002-9383-0227", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ed200c452dc423981354cc103223c0c.json"}}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Int J Qual Stud Health Well-being", "issn": "1748-2631", "issn-l": null, "volume": "18", "issue": "1", "pages": "2251236"}, "abstract": "To illuminate the meaning of social relationships and health concerns as experienced by adolescents and young people during the COVID-19 pandemic.\r\n\r\nA longitudinal qualitative study was conducted. Data reported from 172 adolescents and young people aged 12-24 years in five countries; Chile, South Africa, Sweden, the United Kingdom and the United States collected from May 2020 to June 2021 were analysed via thematic analysis.\r\n\r\nAdolescents and young peoples' experiences of social relationships and health concerns were described in seven themes: Family proximity, conflicts and frustration; difficulties and challenges related to limited living space; peer relations and maintaining friendship in times of social distancing; the importance of school as a place for interaction; vulnerability, emotional distress and uncertainty about the future; health concerns and sense of caring for others; and worries and concerns related to financial hardship. These reports show that the changes to everyday life that were introduced by public responses to the pandemic generated feelings of loneliness, vulnerability, and emotional distress, as well as increased sense of togetherness with family.\r\n\r\nThe everyday lives of adolescents and young people were restricted and affected more by the consequences of the pandemic than by the COVID-19 virus. These experiences had various impacts on well-being and mental health, where some individuals felt more exposed and vulnerable to emotional distress and loneliness than others. Family and peer relationships could be protective and support a sense of togetherness and belonging. Hence, social relationships are important to provide emotional support. Support for adolescents and young people should be tailored accordingly around social and emotional concerns, to encourage health and well-being.", "doi": "10.1080/17482631.2023.2251236", "pmid": "37639471", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10464546"}], "notes": [], "created": "2023-10-05T08:26:01.693Z", "modified": "2023-10-06T04:43:05.249Z"}, {"entity": "publication", "iuid": "b5b0aec2627946a0b9e29efb73968cd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5b0aec2627946a0b9e29efb73968cd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5b0aec2627946a0b9e29efb73968cd0"}}, "title": "A survey of pharmacists' perception of the work environment and patient safety in community pharmacies during the COVID-19 pandemic.", "authors": [{"family": "Ljungberg Persson", "given": "C", "initials": "C"}, {"family": "Nord\u00e9n H\u00e4gg", "given": "A", "initials": "A"}, {"family": "S\u00f6derg\u00e5rd", "given": "B", "initials": "B"}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Explor Res Clin Soc Pharm", "issn": "2667-2766", "issn-l": null, "volume": "12", "issue": null, "pages": "100327"}, "abstract": "Community pharmacies have changed during the COVID-19 pandemic, and new routines have been introduced to address the needs of customers and staff and to reduce the risk of spreading infection. Burnout has been described among staff possibly due to a changed working climate. However, little research has focused on the pandemic's effect on patient safety in community pharmacies.\r\n\r\nTo examine pharmacists' perceptions of the impact of the COVID-19 pandemic on workload, working environment, and patient safety in community pharmacies.\r\n\r\nA survey was distributed to all Swedish community pharmacists, constituting a census study. Questions regarding the pharmacists' perception of the impact of the pandemic on workload, working environment, and patient safety were included. Respondents were asked to provide comments on their working situation. Quantitative results were analysed using descriptive statistics, and comments were analysed using qualitative content analysis.\r\n\r\nThe response rate was 41% (2034 responses). Most pharmacists (62%) considered the workload to be increased during the pandemic while work environment deteriorated (physical work environment was considered worse by 47% of respondents while psychosocial work environment was considered worse by 59%). Despite this, many respondents (55%) believed that patient safety was not affected. Neither having had COVID-19 nor being afraid of contracting it, influenced these perceptions in any substantial way. Findings were consistent regardless of education, professional role, number of years in community pharmacies, or special assignments in the pharmacies. According to the respondents, the communication within pharmacy companies during the pandemic was inadequate.\r\n\r\nThe impact of the pandemic on working conditions is in line with previous findings but the effect on patient safety needs further studies. The respondents felt the management had a limited understanding of the conditions during the pandemic, which stresses the importance of good and clear communication during a crisis.", "doi": "10.1016/j.rcsop.2023.100327", "pmid": "37780549", "labels": {"Category: Social Science & Humanities": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10534261"}, {"db": "pii", "key": "S2667-2766(23)00108-7"}], "notes": [], "created": "2023-11-01T13:33:04.942Z", "modified": "2023-11-02T07:10:43.155Z"}, {"entity": "publication", "iuid": "0b40ee94b7b14b458eb231e8a2746373", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b40ee94b7b14b458eb231e8a2746373.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b40ee94b7b14b458eb231e8a2746373"}}, "title": "Safety, tolerability, and pharmacokinetics of half-life extended SARS-CoV-2-neutralizing monoclonal antibodies AZD7442 (tixagevimab/cilgavimab) in healthy Japanese adults.", "authors": [{"family": "Okada", "given": "Hiroshi", "initials": "H"}, {"family": "Ishikawa", "given": "Kensuke", "initials": "K"}, {"family": "Itoh", "given": "Yohji", "initials": "Y"}, {"family": "Noda", "given": "Yoshinori", "initials": "Y"}, {"family": "Eto", "given": "Takashi", "initials": "T"}, {"family": "Pilla Reddy", "given": "Venkatesh", "initials": "V"}, {"family": "Chen", "given": "Cecil Chi-Keung", "initials": "CC"}, {"family": "Gibbs", "given": "Michael", "initials": "M"}, {"family": "Johnsson", "given": "Eva", "initials": "E"}], "type": "randomized controlled trial", "published": "2023-11-00", "journal": {"title": "J Infect Chemother", "issn": "1437-7780", "issn-l": null, "volume": "29", "issue": "11", "pages": "1061-1067"}, "abstract": "The aim of this study was to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of AZD7442 (tixagevimab/cilgavimab) in healthy Japanese adults.\r\n\r\nIn this randomized, double-blind, placebo-controlled, phase 1 study, AZD7442 was administered intramuscularly (300 or 600 mg) or intravenously (300 or 1000 mg) to healthy Japanese adults. Primary endpoints were safety, tolerability, and pharmacokinetics. Anti-drug antibodies and neutralizing antibody activities were secondary endpoints.\r\n\r\nA total of 40 participants were randomized to receive AZD7442 (n = 30) or placebo (n = 10). Adverse events (AEs) occurred in 12 (40%) and 3 (30%) participants, respectively; there were no deaths, serious AEs, or AEs leading to study withdrawal. Tixagevimab and cilgavimab had mean half-lives of 82.1-95.9 and 77.9-92.0 days, respectively, which were generally similar regardless of administration route. SARS-CoV-2-neutralizing antibody titers were >4-fold higher than baseline levels from Day 8 to Day 211 in participants receiving AZD7442.\r\n\r\nAZD7442 was well tolerated in healthy Japanese adults, with predictable pharmacokinetics and an extended half-life, consistent with previous studies.\r\n\r\ngov, NCT04896541.", "doi": "10.1016/j.jiac.2023.07.014", "pmid": "37524201", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S1341-321X(23)00181-2"}, {"db": "ClinicalTrials.gov", "key": "NCT04896541"}], "notes": [], "created": "2023-10-05T08:27:04.847Z", "modified": "2023-10-06T05:19:49.899Z"}, {"entity": "publication", "iuid": "3b1550b3072e4388b2abda49ad05e774", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b1550b3072e4388b2abda49ad05e774.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b1550b3072e4388b2abda49ad05e774"}}, "title": "Monoclonal antibodies lock down SARS-CoV-2 spike.", "authors": [{"family": "Huang", "given": "Hsiang-Chi", "initials": "H"}, {"family": "Angeletti", "given": "Davide", "initials": "D"}], "type": "journal article", "published": "2023-11-00", "journal": {"title": "Trends Immunol", "issn": "1471-4981", "issn-l": null, "volume": "44", "issue": "11", "pages": "874-876"}, "abstract": "SARS-CoV-2 rapidly accumulated mutations in its immunodominant receptor-binding domain (RBD), rendering all clinically authorized monoclonal antibodies (mAbs) ineffective. Liu et al. unveil potent human mAbs that neutralize all tested SARS-CoV-2 variants by locking the Spike protein RBD in a downward conformation, thus inhibiting receptor engagement.", "doi": "10.1016/j.it.2023.09.006", "pmid": "37805348", "labels": {"Category: Vaccines": null, "Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1471-4906(23)00202-8"}], "notes": [], "created": "2023-11-01T13:33:13.225Z", "modified": "2023-11-02T07:15:29.144Z"}, {"entity": "publication", "iuid": "fff3a02de3024a11a9d52d9ce733906e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fff3a02de3024a11a9d52d9ce733906e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fff3a02de3024a11a9d52d9ce733906e"}}, "title": "Chronic Candida albicans meningitis following critical COVID-19 and serial measurements of (1,3)-\u03b2-D-glucan in cerebrospinal fluid.", "authors": [{"family": "Andreen", "given": "Niklas", "initials": "N"}, {"family": "Brink", "given": "Magnus", "initials": "M"}, {"family": "Hammarstr\u00f6m", "given": "Helena", "initials": "H"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}], "type": "journal article", "published": "2023-11-00", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": "55", "issue": "11", "pages": "794-797"}, "abstract": "Co-infections with invasive candidiasis have been reported to be overrepresented in severe COVID-19. This report presents an unusual case of chronic Candida meningitis following intensive care for COVID-19.", "doi": "10.1080/23744235.2023.2232448", "pmid": "37427429", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Serology": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:08:45.050Z", "modified": "2023-10-04T12:40:11.993Z"}, {"entity": "publication", "iuid": "11826c7f42bd491d80a67fe6d4f63446", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/11826c7f42bd491d80a67fe6d4f63446.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/11826c7f42bd491d80a67fe6d4f63446"}}, "title": "The sociodemographic patterning of sick leave and determinants of longer sick leave after mild and severe COVID-19: a nationwide register-based study in Sweden.", "authors": [{"family": "Spetz", "given": "Malin", "initials": "M"}, {"family": "Natt Och Dag", "given": "Yvonne", "initials": "Y"}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Nwaru", "given": "Chioma", "initials": "C"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Rosvall", "given": "Maria", "initials": "M", "orcid": "0000-0002-7122-9940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b220132e7064d50bb6649cd82a5bb42.json"}}], "type": "journal article", "published": "2023-10-27", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": null, "issue": null, "pages": null}, "abstract": "Studies on sociodemographic differences in sick leave after coronavirus disease 2019 (COVID-19) are limited and research on COVID-19 long-term health consequences has mainly addressed hospitalized individuals. The aim of this study was to investigate the social patterning of sick leave and determinants of longer sick leave after COVID-19 among mild and severe cases.\r\n\r\nThe study population, from the Swedish multi-register observational study SCIFI-PEARL, included individuals aged 18-64 years in the Swedish population, gainfully employed, with a first positive polymerase chain reaction (PCR) test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from 1 January 2020 until 31 August 2021 (n = 661 780). Using logistic regression models, analyses were adjusted for sociodemographic factors, vaccination, prior sick leave, comorbidities and stratified by hospitalization.\r\n\r\nIn total, 37 420 (5.7%) individuals were on sick leave due to COVID-19 in connection with their first positive COVID-19 test. Individuals on sick leave were more often women, older, had lower income and/or were born outside Sweden. These differences were similar across COVID-19 pandemic phases. The highest proportion of sick leave was seen in the oldest age group (10.3%) with an odds ratio of 4.32 (95% confidence interval 4.18-4.47) compared with the youngest individuals. Among individuals hospitalized due to COVID-19, the sociodemographic pattern was less pronounced, and in some models, even reversed. The intersectional analysis revealed considerable variability in sick leave between sociodemographic groups (range: 1.5-17.0%).\r\n\r\nIn the entire Swedish population of gainfully employed individuals, our findings demonstrated evident sociodemographic differences in sick leave due to COVID-19. In the hospitalized group, the social patterning was different and less pronounced.", "doi": "10.1093/eurpub/ckad191", "pmid": "37889580", "labels": {"Funder: VR": null, "Category: Social Science & Humanities": null, "Funder: KAW/SciLifeLab": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7331116"}], "notes": [], "created": "2023-11-01T13:31:38.666Z", "modified": "2023-11-01T13:43:47.208Z"}, {"entity": "publication", "iuid": "a3623fd6bde943a695f15b060417e12f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3623fd6bde943a695f15b060417e12f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3623fd6bde943a695f15b060417e12f"}}, "title": "How did providers of home care for older adults manage the early phase of the Covid-19 pandemic? A qualitative case study of managers' experiences in Region Stockholm.", "authors": [{"family": "Agerholm", "given": "Janne", "initials": "J"}, {"family": "Burstr\u00f6m", "given": "Bo", "initials": "B"}, {"family": "Sch\u00f6n", "given": "P\u00e4r", "initials": "P"}, {"family": "Liljas", "given": "Ann", "initials": "A"}], "type": "journal article", "published": "2023-10-27", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "issn-l": null, "volume": "23", "issue": "1", "pages": "1173"}, "abstract": "In the spring of 2020, the Covid-19 outbreak sent a shock wave through the Swedish society and placed an extraordinary pressure on the health and social care system for older people. In the initial phase there were few guidelines for care providers to follow and staff in home care organisations often had to tackle challenges posed by the pandemic as they appeared. The aim of this study was to understand how the spread of Covid-19 was managed in organisations providing home care to older adults in different municipalities in Region Stockholm, and what actions were taken to minimise the spread of the disease among clients and staff.\r\n\r\nA descriptive qualitative study was performed based on eight interviews with managers of home care providers for older adults in three different municipalities in Region Stockholm.Three of the eight providers operate within an integrated care system. Data were analysed using conventional content analysis.\r\n\r\nThree themes were identified covering actions taken to handle the spread of the virus, feelings of insecurity and anxiety, and internal and external factors influencing how the pandemic was tackled. There was no single strategy followed by all municipalities or organisations, however, there were similarities between the organisations. One such example was the introduction of cohort care and the experience of lacking personal protective equipment. Providers in the integrated care system emphasized some advantages with their system that was seen as facilitators for minimising the risk of spreading the virus, like the joint meetings with managers from both health and social care and the close contact with healthcare professionals in relation to dissemination of hygiene instructions.\r\n\r\nSocial care workers providing home care to older persons are an important group in preventing dissemination of infectious diseases like Covid-19. For better readiness and preparedness for future pandemics, municipal home care services would need larger stocks of personal protective equipment, clear guidelines and more training on how to reduce dissemination of disease. Ways to achieve closer communication between health and social care providers should also be investigated.", "doi": "10.1186/s12913-023-10173-8", "pmid": "37891523", "labels": {"Funder: VR": null, "Funder: Forte": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10612274"}, {"db": "pii", "key": "10.1186/s12913-023-10173-8"}], "notes": [], "created": "2023-11-01T13:32:23.591Z", "modified": "2023-11-02T07:03:41.915Z"}, {"entity": "publication", "iuid": "389a662518cd4a27a53b699cd6cea155", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/389a662518cd4a27a53b699cd6cea155.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/389a662518cd4a27a53b699cd6cea155"}}, "title": "Associations between psychosocial wellbeing and experience of gender-based violence at community, household, and intimate-partner levels among a cross-sectional cohort of young people living with and without HIV during COVID-19 in Cape Town, South Africa.", "authors": [{"family": "Hartmann", "given": "Miriam", "initials": "M"}, {"family": "Giovenco", "given": "Danielle", "initials": "D"}, {"family": "Zeebari", "given": "Zangin", "initials": "Z"}, {"family": "Itzikowitz", "given": "Gina", "initials": "G"}, {"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM"}, {"family": "Nielsen", "given": "Anna", "initials": "A"}, {"family": "Pettifor", "given": "Audrey", "initials": "A"}, {"family": "Bekker", "given": "Linda-Gail", "initials": "L"}, {"family": "K\u00e5gesten", "given": "Anna E", "initials": "AE"}], "type": "journal article", "published": "2023-10-27", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "23", "issue": "1", "pages": "2115"}, "abstract": "Growing evidence indicates that gender-based violence (GBV) increased during COVID-19. We investigated self-reported impact of the pandemic on GBV at community, household and intimate partner (IPV) levels among young people and its associations with psychosocial wellbeing, i.e., COVID-related stressors and mental health.\r\n\r\nCross-sectional data were drawn from a survey with young people ages 13-24 (N = 536) living with HIV (YPLWH) and without HIV (YPLWoH), in peri-urban Cape Town, South Africa. The survey, conducted February-October 2021, examined the impact of the initial lockdown on experience and perceived changes in GBV at each level, and pandemic-related psychosocial wellbeing. Descriptive statistics and binomial and multinomial regression analyses were conducted to illustrate exposure and perceived changes in GBV since lockdown, and their association with COVID-related stress factors (e.g., social isolation, anxiety about COVID), mental health (e.g., depression, anxiety), and other risk factors (e.g., age, gender, socioeconomic status) by HIV status.\r\n\r\nParticipants were 70% women with mean age 19 years; 40% were living with HIV. Since lockdown, YPLWoH were significantly more likely than YPLWH to perceive community violence as increasing (45% vs. 28%, p < 0.001), and to report household violence (37% vs. 23%, p = 0.006) and perceive it as increasing (56% vs. 27%, p = 0.002) (ref: decreasing violence). YPLWoH were also more likely to report IPV experience (19% vs. 15%, p = 0.41) and perception of IPV increasing (15% vs. 8%, p = 0.92). In adjusted models, COVID-related stressors and common mental health disorders were only associated with household violence. However, indicators of economic status such as living in informal housing (RRR = 2.07; 95% CI = 1.12-3.83) and food insecurity (Community violence: RRR = 1.79; 95% CI = 1.00-3.20; Household violence: RRR = 1.72; 95% CI = 1.15-2.60) emerged as significant risk factors for exposure to increased GBV particularly among YPLWoH.\r\n\r\nFindings suggest that for young people in this setting, GBV at community and household levels was more prevalent during COVID-19 compared to IPV, especially for YPLWoH. While we found limited associations between COVID-related stressors and GBV, the perceived increases in GBV since lockdown in a setting where GBV is endemic, and the association of household violence with mental health, is a concern for future pandemic responses and should be longitudinally assessed.", "doi": "10.1186/s12889-023-16945-5", "pmid": "37891509", "labels": {"Funder: VR": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10612288"}, {"db": "pii", "key": "10.1186/s12889-023-16945-5"}], "notes": [], "created": "2023-11-01T13:33:27.833Z", "modified": "2023-11-02T07:22:42.743Z"}, {"entity": "publication", "iuid": "2232c85abf2b4e13ae16b60025ee1d92", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2232c85abf2b4e13ae16b60025ee1d92.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2232c85abf2b4e13ae16b60025ee1d92"}}, "title": "Outcomes of SARS-CoV-2 Omicron Variant Infections Compared with Seasonal Influenza and Respiratory Syncytial Virus Infections in Adults Attending the Emergency Department: A Multicentre Cohort Study.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P", "orcid": "0000-0003-3153-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd6af5accfc84ff9a81983a5ab6683aa.json"}}, {"family": "Karlsson Valik", "given": "John", "initials": "J", "orcid": "0000-0002-4521-1886", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eac431272ad4d8eb13c8d56ddef182c.json"}}, {"family": "Abdel Halim", "given": "Lina", "initials": "L"}, {"family": "Alfv\u00e9n", "given": "Tobias", "initials": "T", "orcid": "0000-0002-2328-3512", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3851560b984401780a380ab1262cd8b.json"}}, {"family": "Naucler", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2023-10-26", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "issn-l": "1058-4838", "volume": null, "issue": null, "pages": null}, "abstract": "There is a controversy over the impact of SARS-CoV-2 infections in an era of less virulent variants and an increasing population immunity. We compared outcomes in adults attending the emergency department (ED) with an Omicron, influenza, or respiratory syncytial virus (RSV) infection.\r\n\r\nRetrospective multicentre cohort study including adults attending the ED in six acute care hospitals in Stockholm County, Sweden, with an Omicron, influenza, or RSV infection during 2021-22 and 2015-19. During 2021-22, patients were tested for all three viruses by multiplex PCR testing. The primary outcome was 30-day all-cause mortality. Secondary outcomes were 90-day all-cause mortality, hospitalization, and intensive care unit (ICU) admission.\r\n\r\nA total of 6,385 patients from 2021-22 were included in the main analyses: 4,833 Omicron, 1,099 influenza, and 453 RSV. The 30-day mortality was 7.9% (n=381) in the Omicron, 2.5% (n=28) in the influenza, and 6.0% (n=27) in the RSV cohort. Patients with Omicron had an adjusted 30-day mortality odds ratio (OR) of 2.36 (95% confidence interval [CI] 1.60-3.62) compared with influenza and 1.42 (95% CI 0.94-2.21) compared with RSV. Among unvaccinated Omicron patients, stronger associations were observed compared with both influenza (OR 5.51 [95% CI 3.41-9.18]) and RSV (OR 3.29 [95% CI 2.01-5.56]). Similar trends were observed for secondary outcomes. Findings were consistent in comparisons with 5,709 pre-pandemic influenza 995 RSV patients.\r\n\r\nIn patients attending the ED, infections with Omicron were both more common and associated with more severe outcomes compared with influenza and RSV, in particular among unvaccinated patients.", "doi": "10.1093/cid/ciad660", "pmid": "37883521", "labels": {"Funder: VR": null, "Category: Health": null, "Category: Vaccines": null, "Funder: H2020": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7330559"}], "notes": [], "created": "2023-11-01T13:34:17.238Z", "modified": "2023-11-02T07:47:44.463Z"}, {"entity": "publication", "iuid": "cfcf4b588dcc4cdb8f4ad99979423778", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfcf4b588dcc4cdb8f4ad99979423778.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfcf4b588dcc4cdb8f4ad99979423778"}}, "title": "Cardiovascular dysautonomia in postacute sequelae of SARS-CoV-2 infection.", "authors": [{"family": "St\u00e5hlberg", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0319-6240", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75523cbe45e04142bb03b50707b96804.json"}}, {"family": "Mahdi", "given": "Ali", "initials": "A"}, {"family": "Johansson", "given": "Madeleine", "initials": "M", "orcid": "0000-0001-9057-9148", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f86daf2351f0466f83705bfa26ba0b4a.json"}}, {"family": "Fedorowski", "given": "Artur", "initials": "A", "orcid": "0000-0002-5352-6327", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2ef9375bfba4311868834aec838c8a3.json"}}, {"family": "Olshansky", "given": "Brian", "initials": "B", "orcid": "0000-0002-6044-045X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21da77c6851743e688ce07c56cb0ba75.json"}}], "type": "journal article", "published": "2023-10-25", "journal": {"title": "J Cardiovasc Electrophysiol", "issn": "1540-8167", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Coronavirus disease 2019 (COVID-19) has led to a worldwide pandemic that continues to transform but will not go away. Cardiovascular dysautonomia in postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection has led to persistent symptoms in a large number of patients. Here, we define the condition and its associated symptoms as well as potential mechanisms responsible. We provide a careful and complete overview of the topic addressing novel studies and a generalized approach to the management of individuals with this complex and potentially debilitating problem. We also discuss future research directions and the important knowledge gaps to be addressed in ongoing and planned studies.", "doi": "10.1111/jce.16117", "pmid": "37877234", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:33:10.141Z", "modified": "2023-11-02T07:14:18.246Z"}, {"entity": "publication", "iuid": "2d681a8066d842df8318bbad966b4f7c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d681a8066d842df8318bbad966b4f7c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d681a8066d842df8318bbad966b4f7c"}}, "title": "The role of primary health care in long-term care facilities during the COVID-19 pandemic in 30 European countries: a retrospective descriptive study (Eurodata study).", "authors": [{"family": "Guisado-Clavero", "given": "Marina", "initials": "M", "orcid": "0000-0002-8448-2929", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe6cb00ce6e64ea9ae551a4a65c1093c.json"}}, {"family": "Ares-Blanco", "given": "Sara", "initials": "S", "orcid": "0000-0002-4984-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5929b4be5ff946a2af9b33fde3fb09ec.json"}}, {"family": "Serafini", "given": "Alice", "initials": "A", "orcid": "0000-0002-7396-2839", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dfd0165d3afe49f49370124c8a379a81.json"}}, {"family": "Del Rio", "given": "Lourdes Ramos", "initials": "LR", "orcid": "0000-0003-4850-2053", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/629e28d8cf1d4ba3926ba037e14f5742.json"}}, {"family": "Larrondo", "given": "Ileana Gefaell", "initials": "IG", "orcid": "0000-0002-1635-1003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a6e202b315e4966a1fc58919d4f4e4e.json"}}, {"family": "Fitzgerald", "given": "Louise", "initials": "L", "orcid": "0009-0009-8039-3097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54a11aeb7912445e91a8861314dc9dc3.json"}}, {"family": "Vinker", "given": "Shlomo", "initials": "S"}, {"family": "van Pottebergh", "given": "Gijs", "initials": "G"}, {"family": "Valtonen", "given": "Kirsi", "initials": "K"}, {"family": "Vaes", "given": "Bert", "initials": "B"}, {"family": "Yilmaz", "given": "Canan Tuz", "initials": "CT"}, {"family": "Torzsa", "given": "P\u00e9ter", "initials": "P"}, {"family": "Tilli", "given": "Paula", "initials": "P"}, {"family": "Sentker", "given": "Theresa", "initials": "T"}, {"family": "Seifert", "given": "Bohumil", "initials": "B"}, {"family": "Saurek-Aleksandrovska", "given": "Natalija", "initials": "N"}, {"family": "Sattler", "given": "Martin", "initials": "M"}, {"family": "Petricek", "given": "Goranka", "initials": "G"}, {"family": "Petrazzuoli", "given": "Ferdinando", "initials": "F"}, {"family": "Petek", "given": "Davorina", "initials": "D"}, {"family": "Perj\u00e9s", "given": "\u00c1bel", "initials": "\u00c1"}, {"family": "L\u00f3pez", "given": "Naldy Parodi", "initials": "NP"}, {"family": "Neves", "given": "Ana Luisa", "initials": "AL"}, {"family": "Murauskien\u0117", "given": "Liubov\u0117", "initials": "L"}, {"family": "Lingner", "given": "Heidrun", "initials": "H"}, {"family": "Nessler", "given": "Katarzyna", "initials": "K"}, {"family": "Heleno", "given": "Bruno", "initials": "B"}, {"family": "Krzto\u0144-Kr\u00f3lewiecka", "given": "Anna", "initials": "A"}, {"family": "Kosti\u0107", "given": "Milena", "initials": "M"}, {"family": "Korkmaz", "given": "B\u00fcsra \u00c7imen", "initials": "B\u00c7"}, {"family": "Kne\u017eevi\u0107", "given": "Sne\u017eana", "initials": "S"}, {"family": "Kirkovski", "given": "Aleksandar", "initials": "A"}, {"family": "Karathanos", "given": "Vasilis Trifon", "initials": "VT"}, {"family": "Jandri\u0107-Ko\u010di\u0107", "given": "Marijana", "initials": "M"}, {"family": "Ivanna", "given": "Shushman", "initials": "S"}, {"family": "\u0406\u043b\u044c\u043a\u043e\u0432", "given": "\u041e\u043a\u0441\u0430\u043d\u0430", "initials": "\u041e"}, {"family": "Hoffmann", "given": "Kathryn", "initials": "K"}, {"family": "Han\u017eeva\u010dki", "given": "Miroslav", "initials": "M"}, {"family": "G\u00f3mez-Johansson", "given": "Mila", "initials": "M"}, {"family": "Gjorgjievski", "given": "Dragan", "initials": "D"}, {"family": "Domeyer", "given": "Philippe-Richard J", "initials": "PJ"}, {"family": "Pe\u00f1a", "given": "Maryher Delphin", "initials": "MD"}, {"family": "Divjak", "given": "Asja \u0106osi\u0107", "initials": "A\u0106"}, {"family": "Busneag", "given": "Iliana-Carmen", "initials": "I"}, {"family": "Brutskaya-Stempkovskaya", "given": "Elena", "initials": "E"}, {"family": "Bayen", "given": "Sabine", "initials": "S"}, {"family": "Bakola", "given": "Maria", "initials": "M"}, {"family": "Adler", "given": "Limor", "initials": "L"}, {"family": "Assenova", "given": "Radost", "initials": "R"}, {"family": "Astier-Pe\u00f1a", "given": "Mar\u00eda Pilar", "initials": "MP", "orcid": "0000-0002-3192-7672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/585b3e1ed7df4d63b0342ab0d96ef9c4.json"}}, {"family": "G\u00f3mez Bravo", "given": "Raquel", "initials": "R"}], "type": "journal article", "published": "2023-10-24", "journal": {"title": "Prim Health Care Res Dev", "issn": "1477-1128", "issn-l": null, "volume": "24", "issue": null, "pages": "e60"}, "abstract": "Primary health care (PHC) supported long-term care facilities (LTCFs) in attending COVID-19 patients. The aim of this study is to describe the role of PHC in LTCFs in Europe during the early phase of the pandemic.\r\n\r\nRetrospective descriptive study from 30 European countries using data from September 2020 collected with an ad hoc semi-structured questionnaire. Related variables are SARS-CoV-2 testing, contact tracing, follow-up, additional testing, and patient care.\r\n\r\nTwenty-six out of the 30 European countries had PHC involvement in LTCFs during the COVID-19 pandemic. PHC participated in initial medical care in 22 countries, while, in 15, PHC was responsible for SARS-CoV-2 test along with other institutions. Supervision of individuals in isolation was carried out mostly by LTCF staff, but physical examination or symptom's follow-up was performed mainly by PHC.\r\n\r\nPHC has participated in COVID-19 pandemic assistance in LTCFs in coordination with LTCF staff, public health officers, and hospitals.", "doi": "10.1017/S1463423623000312", "pmid": "37873623", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10594530"}, {"db": "pii", "key": "S1463423623000312"}], "notes": [], "created": "2023-11-01T13:31:47.959Z", "modified": "2023-11-01T13:48:56.332Z"}, {"entity": "publication", "iuid": "b5f16d32127a4318ba630294e5793728", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5f16d32127a4318ba630294e5793728.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5f16d32127a4318ba630294e5793728"}}, "title": "COVID-19 Recovery: Consistent Absence of Cerebrospinal Fluid Biomarker Abnormalities in Patients With Neurocognitive Post-COVID Complications.", "authors": [{"family": "Kanberg", "given": "Nelly", "initials": "N", "orcid": "0000-0002-1064-995X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84d593bfda8f42688e9d4fe713158679.json"}}, {"family": "Grahn", "given": "Anna", "initials": "A"}, {"family": "Stentoft", "given": "Erika", "initials": "E"}, {"family": "Bremell", "given": "Daniel", "initials": "D"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Studahl", "given": "Marie", "initials": "M"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Sch\u00f6ll", "given": "Michael", "initials": "M", "orcid": "0000-0001-7800-1781", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebf046923a9d4540a7a72578663116f2.json"}}, {"family": "Gostner", "given": "Johanna M", "initials": "JM"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Padmanabhan", "given": "Nikhil", "initials": "N"}, {"family": "Cohen", "given": "Rachel", "initials": "R"}, {"family": "Misaghian", "given": "Salvia", "initials": "S"}, {"family": "Romero", "given": "Daniel", "initials": "D"}, {"family": "Campbell", "given": "Christopher", "initials": "C"}, {"family": "Mathew", "given": "Anu", "initials": "A", "orcid": "0000-0003-3327-3083", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc281597abd2491499abebd7bf90fb20.json"}}, {"family": "Wang", "given": "Mingyue", "initials": "M"}, {"family": "Sigal", "given": "George", "initials": "G", "orcid": "0000-0001-7149-6400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5a9e814e36040718224e726b320c248.json"}}, {"family": "Stengelin", "given": "Martin", "initials": "M"}, {"family": "Ed\u00e9n", "given": "Arvid", "initials": "A", "orcid": "0000-0003-2817-9981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54411b4f4cbe422697c5eb3080c23e2c.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2023-10-24", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899", "volume": null, "issue": null, "pages": null}, "abstract": "To investigate evidence of residual viral infection, intrathecal immune activation, central nervous system (CNS) injury, and humoral responses in cerebrospinal fluid (CSF) and plasma in patients recovering from coronavirus disease 2019 (COVID-19), with or without neurocognitive post-COVID condition (PCC).\r\n\r\nThirty-one participants (25 with neurocognitive PCC) underwent clinical examination, lumbar puncture, and venipuncture \u22653 months after COVID-19 symptom onset. Healthy volunteers were included. CSF and plasma severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid and spike antigen (N-Ag, S-Ag), and CSF biomarkers of immune activation and neuronal injury were analyzed.\r\n\r\nSARS-CoV-2 N-Ag or S-Ag were undetectable in all samples and no participant had pleocytosis. We detected no significant differences in CSF and plasma cytokine concentrations, albumin ratio, IgG index, neopterin, \u03b22M, or in CSF biomarkers of neuronal injury and astrocytic damage. Furthermore, principal component analysis (PCA1) analysis did not indicate any significant differences between the study groups in the marker sets cytokines, neuronal markers, or anti-cytokine autoantibodies.\r\n\r\nWe found no evidence of ongoing viral replication, immune activation, or CNS injury in plasma or CSF in patients with neurocognitive PCC compared with COVID-19 controls or healthy volunteers, suggesting that neurocognitive PCC is a consequence of events suffered during acute COVID-19 rather than persistent viral CNS infection or residual CNS inflammation.", "doi": "10.1093/infdis/jiad395", "pmid": "37874918", "labels": {"Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7328977"}], "notes": [], "created": "2023-11-01T13:31:31.776Z", "modified": "2023-11-01T13:41:08.175Z"}, {"entity": "publication", "iuid": "2817222fdd3a4e4b90b4f90242a904e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2817222fdd3a4e4b90b4f90242a904e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2817222fdd3a4e4b90b4f90242a904e8"}}, "title": "Health-related quality of life after surviving intensive care for COVID-19: a prospective multicenter cohort study.", "authors": [{"family": "Halvorsen", "given": "Peter", "initials": "P"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "H\u00e4stbacka", "given": "Johanna", "initials": "J"}, {"family": "Larsson", "given": "Ing-Marie", "initials": "I"}, {"family": "Eklund", "given": "Rakel", "initials": "R"}, {"family": "Arnberg", "given": "Filip K", "initials": "FK"}, {"family": "Hokkanen", "given": "Laura", "initials": "L"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Wallin", "given": "Ewa", "initials": "E"}, {"family": "Orwelius", "given": "Lotti", "initials": "L"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}], "type": "journal article", "published": "2023-10-21", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "18035"}, "abstract": "In survivors of severe coronavirus disease 2019 (COVID-19) incomplete mental and physical recovery may considerably impact daily activities and health-related quality of life (HRQoL). HRQoL can be evaluated with the RAND-36 questionnaire, a multidimensional instrument that assesses physical and mental aspects of health in eight dimensions. The objective was to investigate HRQoL in intensive care patients previously treated for COVID-19 at three Nordic university hospitals, in a prospective multi-center cohort study. HRQoL was measured using RAND-36, 3-9 months after discharge from intensive care units (ICU). One hospital performed a second follow-up 12 months after discharge. A score under the lower limit of the 95% confidence interval in the reference cohorts was considered as significantly reduced HRQoL. We screened 542 and included 252 patients. There was more than twice as many male (174) as female (78) patients and the median age was 61 (interquartile range, IQR 52-69) years. Hypertension was the most common comorbidity observed in 132 (52%) patients and 121 (48%) patients were mechanically ventilated for a median of 8 (IQR 4-14) days. In RAND-36 physical functioning, physical role functioning, general health (p < 0.001 for all) and social functioning (p < 0.05) were below reference, whereas bodily pain, emotional role functioning and mental health were not. In a time-to-event analysis female sex was associated with a decreased chance of reaching the reference HRQoL in the physical function, bodily pain and mental health dimensions. Higher body mass index was found in the physical functioning dimension and hypertension in the physical functioning, vitality and social functioning dimensions. Similar results were seen for diabetes mellitus in general health, vitality and mental health dimensions, as well as pulmonary illness in the physical role functioning dimension and psychiatric diagnosis in the social functioning dimension. Mechanical ventilation was associated with a decreased likelihood of achieving reference HRQoL in the bodily pain and physical functioning dimensions. Patients treated in an ICU because of COVID-19 had lower HRQoL 3-9 months after ICU discharge than 95% of the general population. Physical dimensions were more severely affected than mental dimensions. Female sex and several comorbidities were associated with a slower rate of recovery.Study registration: clinicaltrials.gov: NCT04316884 registered on the 13th of March 2020, NCT04474249 registered on the 29th of June 2020 and NCT04864938 registered on the 4th of April 2021.", "doi": "10.1038/s41598-023-45346-2", "pmid": "37865685", "labels": {"Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Funder: NordForsk": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10590404"}, {"db": "pii", "key": "10.1038/s41598-023-45346-2"}, {"db": "ClinicalTrials.gov", "key": "NCT04316884"}, {"db": "ClinicalTrials.gov", "key": "NCT04864938"}, {"db": "ClinicalTrials.gov", "key": "NCT04474249"}], "notes": [], "created": "2023-11-01T13:32:33.866Z", "modified": "2023-11-02T07:09:16.017Z"}, {"entity": "publication", "iuid": "c6d57c9e348f451a85788e6e02f86cc5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c6d57c9e348f451a85788e6e02f86cc5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c6d57c9e348f451a85788e6e02f86cc5"}}, "title": "Sex-stratified patterns of emergency cardiovascular admissions prior and during the COVID-19 pandemic.", "authors": [{"family": "Gajewski", "given": "Piotr", "initials": "P"}, {"family": "B\u0142aziak", "given": "Miko\u0142aj", "initials": "M"}, {"family": "Urban", "given": "Szymon", "initials": "S"}, {"family": "Garus", "given": "Mateusz", "initials": "M"}, {"family": "Braunschweig", "given": "Frieder", "initials": "F"}, {"family": "Caldeira", "given": "Daniel", "initials": "D"}, {"family": "Gawor", "given": "Antoni", "initials": "A"}, {"family": "Greenwood", "given": "John P", "initials": "JP"}, {"family": "Guzik", "given": "Mateusz", "initials": "M"}, {"family": "Halfwerk", "given": "Frank R", "initials": "FR"}, {"family": "Iwanek", "given": "Gracjan", "initials": "G"}, {"family": "Jarocki", "given": "Micha\u0142", "initials": "M"}, {"family": "Jura", "given": "Maksym", "initials": "M"}, {"family": "Krzystek-Korpacka", "given": "Ma\u0142gorzata", "initials": "M"}, {"family": "Lewandowski", "given": "\u0141ukasz", "initials": "\u0141"}, {"family": "Lund", "given": "Lars H", "initials": "LH"}, {"family": "Matysiak", "given": "Micha\u0142", "initials": "M"}, {"family": "Pinto", "given": "Fausto", "initials": "F"}, {"family": "Sleziak", "given": "Jakub", "initials": "J"}, {"family": "Wietrzyk", "given": "Weronika", "initials": "W"}, {"family": "Sokolski", "given": "Mateusz", "initials": "M"}, {"family": "Biegus", "given": "Jan", "initials": "J"}, {"family": "Ponikowski", "given": "Piotr", "initials": "P"}, {"family": "Zymli\u0144ski", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2023-10-20", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "17924"}, "abstract": "The COVID-19 pandemic has had a significant impact on global public health, with long-term consequences that are still largely unknown. This study aimed to assess the data regarding acute cardiovascular hospital admissions in five European centers before and during the pandemic. A multicenter, multinational observational registry was created, comparing admissions to the emergency departments during a 3-months period in 2020 (during the pandemic) with the corresponding period in 2019 (pre-pandemic). Data on patient demographics, COVID-19 test results, primary diagnosis, comorbidities, heart failure profile, medication use, and laboratory results were collected. A total of 8778 patients were included in the analysis, with 4447 patients in 2019 and 4331 patients in 2020. The results showed significant differences in the distribution of cardiovascular diseases between the two years. The frequency of pulmonary embolism (PE) increased in 2020 compared to 2019, while acute heart failure (AHF) and other cardiovascular diseases decreased. The odds of PE incidence among hospitalized patients in 2020 were 1.316-fold greater than in 2019. The incidence of AHF was 50.83% less likely to be observed in 2020, and the odds for other cardiovascular diseases increased by 17.42% between the 2 years. Regarding acute coronary syndrome (ACS), the distribution of its types differed between 2019 and 2020, with an increase in the odds of ST-segment elevation myocardial infarction (STEMI) in 2020. Stratification based on sex revealed further insights. Among men, the incidence of AHF decreased in 2020, while other cardiovascular diseases increased. In women, only the incidence of STEMI showed a significant increase. When analyzing the influence of SARS-CoV-2 infection, COVID-positive patients had a higher incidence of PE compared to COVID-negative patients. COVID-positive patients with ACS also exhibited symptoms of heart failure more frequently than COVID-negative patients. These findings provide valuable information on the impact of the COVID-19 pandemic on acute cardiovascular hospital admissions. The increased incidence of PE and changes in the distribution of other cardiovascular diseases highlight the importance of monitoring and managing cardiovascular health during and post pandemic period. The differences observed between sexes emphasize the need for further research to understand potential sex-specific effects of COVID-19 on cardiovascular outcomes.", "doi": "10.1038/s41598-023-44400-3", "pmid": "37864029", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10589214"}, {"db": "pii", "key": "10.1038/s41598-023-44400-3"}], "notes": [], "created": "2023-11-01T13:31:59.668Z", "modified": "2023-11-01T13:52:38.607Z"}, {"entity": "publication", "iuid": "8634058b134c4f2fba1f708de9f6f4d1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8634058b134c4f2fba1f708de9f6f4d1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8634058b134c4f2fba1f708de9f6f4d1"}}, "title": "Exploring the Operational and Technical Changes in the Healthcare Sector During the COVID-19 Pandemic.", "authors": [{"family": "Muzaik", "given": "Suhail", "initials": "S"}, {"family": "Davoody", "given": "Nadia", "initials": "N"}], "type": "journal article", "published": "2023-10-20", "journal": {"title": "Stud Health Technol Inform", "issn": "1879-8365", "issn-l": null, "volume": "309", "issue": null, "pages": "277-281"}, "abstract": "The COVID-19 pandemic has affected the healthcare sector globally including Sweden, creating subsequent operational and technical changes to the wide range of digital healthcare services utilized by healthcare professionals or end consumers. A qualitative study using a self-assessment survey based on the national health services digital maturity assessment was used to study these changes from the perspective of personnel working in Swedish healthcare-related organizations. The number of 30 respondents was selected using purposive sampling, out of them 11 responded. The study highlighted positively perceived changes such as boosting digitalization, improving the procurement process, and introducing crisis management teams. Improving the offered digital services, the tools' effectiveness, efficiency, and technical support were also some of the results. On the contrary, the negatively perceived changes were limiting access to the services, limiting technical support, and reprioritizing non-essential services and projects.", "doi": "10.3233/SHTI230796", "pmid": "37869857", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "SHTI230796"}], "notes": [], "created": "2023-11-01T13:33:54.946Z", "modified": "2023-11-02T07:31:50.682Z"}, {"entity": "publication", "iuid": "f60ebbc57875444e85f44356aacf41f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f60ebbc57875444e85f44356aacf41f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f60ebbc57875444e85f44356aacf41f9"}}, "title": "Dual spatially resolved transcriptomics for human host-pathogen colocalization studies in FFPE tissue sections.", "authors": [{"family": "Sounart", "given": "Hailey", "initials": "H"}, {"family": "L\u00e1z\u00e1r", "given": "Enik\u0151", "initials": "E"}, {"family": "Masarapu", "given": "Yuvarani", "initials": "Y"}, {"family": "Wu", "given": "Jian", "initials": "J"}, {"family": "V\u00e1rkonyi", "given": "Tibor", "initials": "T"}, {"family": "Glasz", "given": "Tibor", "initials": "T"}, {"family": "Kiss", "given": "Andr\u00e1s", "initials": "A"}, {"family": "Borgstr\u00f6m", "given": "Erik", "initials": "E"}, {"family": "Hill", "given": "Andrew", "initials": "A"}, {"family": "Rezene", "given": "Sefanit", "initials": "S"}, {"family": "Gupta", "given": "Soham", "initials": "S"}, {"family": "Jurek", "given": "Aleksandra", "initials": "A"}, {"family": "Niesnerov\u00e1", "given": "Anezka", "initials": "A"}, {"family": "Druid", "given": "Henrik", "initials": "H"}, {"family": "Bergmann", "given": "Olaf", "initials": "O"}, {"family": "Giacomello", "given": "Stefania", "initials": "S", "orcid": "0000-0003-0738-1574", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8bc73b6281054b07880ffbe190731e8b.json"}}], "type": "journal article", "published": "2023-10-19", "journal": {"title": "Genome Biol", "issn": "1474-760X", "issn-l": null, "volume": "24", "issue": "1", "pages": "237"}, "abstract": "Technologies to study localized host-pathogen interactions are urgently needed. Here, we present a spatial transcriptomics approach to simultaneously capture host and pathogen transcriptome-wide spatial gene expression information from human formalin-fixed paraffin-embedded (FFPE) tissue sections at a near single-cell resolution. We demonstrate this methodology in lung samples from COVID-19 patients and validate our spatial detection of SARS-CoV-2 against RNAScope and in situ sequencing. Host-pathogen colocalization analysis identified putative modulators of SARS-CoV-2 infection in human lung cells. Our approach provides new insights into host response to pathogen infection through the simultaneous, unbiased detection of two transcriptomes in FFPE samples.", "doi": "10.1186/s13059-023-03080-y", "pmid": "37858234", "labels": {"Funder: VR": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10588020"}, {"db": "pii", "key": "10.1186/s13059-023-03080-y"}], "notes": [], "created": "2023-11-01T13:31:44.650Z", "modified": "2023-11-01T13:46:37.615Z"}, {"entity": "publication", "iuid": "2f9153d723224d5bbe532af9791850a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2f9153d723224d5bbe532af9791850a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2f9153d723224d5bbe532af9791850a1"}}, "title": "Associations between the COVID-19 pandemic and women's fertility intentions: a multi-country, cross-sectional (I-SHARE) study.", "authors": [{"family": "Zhao", "given": "Min", "initials": "M", "orcid": "0000-0002-2997-2431", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/949b26f15bec49f69f865c784f079101.json"}}, {"family": "O'Hara", "given": "Caitlin Alsandria", "initials": "CA"}, {"family": "Sahril", "given": "Norhafizah Bte", "initials": "NB"}, {"family": "Liu", "given": "Huijun", "initials": "H"}, {"family": "Pei", "given": "Kaiyan", "initials": "K"}, {"family": "Ivanova", "given": "Olena", "initials": "O"}, {"family": "Larsson", "given": "Elin C", "initials": "EC"}, {"family": "Shamu", "given": "Simukai", "initials": "S"}, {"family": "Kpokiri", "given": "Eneyi", "initials": "E"}, {"family": "Cleeve", "given": "Amanda", "initials": "A"}, {"family": "Tucker", "given": "Joseph D", "initials": "JD"}, {"family": "Michielsen", "given": "Kristien", "initials": "K"}, {"family": "Zhang", "given": "Wei-Hong", "initials": "W"}], "type": "journal article", "published": "2023-10-19", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-2009", "issn-l": "2515-1991", "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic, together with the subsequent social distancing measures, could lead to shifts in family and fertility planning. This study aimed to explore the associations between the COVID-19 pandemic and changes in fertility intentions among an international sample of reproductive-aged women.\r\n\r\nA multi-country, cross-sectional study based on data from 10 672 women aged 18-49 years who participated in the International Sexual Health And REproductive Health (I-SHARE) study, which organised an international online survey between July 2020 and February 2021. Factors associated with changes in fertility intentions were explored using multinomial probit regression models. Cluster-robust standard errors were used to calculate model parameters.\r\n\r\nOf 10 672 included reproductive-aged women, 14.4% reported changing their fertility intentions due to the pandemic, with 10.2% postponement and 4.2% acceleration. Women who had ever been isolated/quarantined were more likely to postpone their fertility intentions (adjusted odds ratio (AOR)=1.41; 95% CI 1.18 to 1.69) compared with those who had not; women who lived with a steady partner were more likely to want children sooner (AOR=1.57; 95% CI 1.10 to 2.23) compared with those who did not; and those who reported a higher frequency of getting angry, feeling frustrated, or worrying about their finances were more likely to postpone their fertility intentions. The main findings were robust in the sensitivity analyses.\r\n\r\nMost women who changed fertility intentions because of the pandemic have postponed intentions to expand their families. The pandemic-induced exposures were associated with these postponements.", "doi": "10.1136/bmjsrh-2023-201819", "pmid": "37857464", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjsrh-2023-201819"}], "notes": [], "created": "2023-11-01T13:34:07.164Z", "modified": "2023-11-02T07:41:44.536Z"}, {"entity": "publication", "iuid": "2d38dba1bc134593b8a0bce3328c0c0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d38dba1bc134593b8a0bce3328c0c0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d38dba1bc134593b8a0bce3328c0c0e"}}, "title": "Increased risk of hospitalization, intensive care and death due to COVID-19 in patients with adrenal insufficiency: A Swedish nationwide study.", "authors": [{"family": "Bergthorsdottir", "given": "Ragnhildur", "initials": "R", "orcid": "0000-0002-9535-8632", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eca588e634a2462e9ba1a6558944f240.json"}}, {"family": "Esposito", "given": "Daniela", "initials": "D"}, {"family": "Olsson", "given": "Daniel S", "initials": "DS"}, {"family": "Ragnarsson", "given": "Oskar", "initials": "O", "orcid": "0000-0003-0204-9492", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af4ee421a70e4975885e173d824cbaf2.json"}}, {"family": "Dahlqvist", "given": "Per", "initials": "P"}, {"family": "Bensing", "given": "Sophie", "initials": "S"}, {"family": "N\u00e5tman", "given": "Jonatan", "initials": "J"}, {"family": "Johannsson", "given": "Gudmundur", "initials": "G"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2023-10-18", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Patients with adrenal insufficiency (AI) have excess morbidity and mortality related to infectious disorders. Whether patients with AI have increased morbidity and mortality from COVID-19 is unknown.\r\n\r\nIn this linked Swedish national register-based cohort study, patients with primary and secondary AI diagnosis were identified and followed from 1 January 2020 to 28 February 2021. They were compared with a control cohort from the general population matched 10:1 for age and sex. The following COVID-19 outcomes were studied: incidence of COVID-19 infection, rates of hospitalization, intensive care admission and death. Hazard ratios (HR) with 95% confidence intervals (95% CI) adjusted for socioeconomic factors and comorbidities were estimated using Cox regression analysis.\r\n\r\nWe identified 5430 patients with AI and 54,300 matched controls: There were 47.6% women, mean age was 57.1 (standard deviation 18.1) years, and the frequency of COVID-19 infection was similar, but the frequency of hospitalization (2.1% vs. 0.8%), intensive care (0.3% vs. 0.1%) and death (0.8% vs. 0.2%) for COVID-19 was higher in AI patients than matched controls. After adjustment for socioeconomic factors and comorbidities, the HR (95% CI) was increased for hospitalization (1.96, 1.59-2.43), intensive care admission (2.76, 1.49-5.09) and death (2.29, 1.60-3.28).\r\n\r\nPatients with AI have a similar incidence of COVID-19 infection to a matched control population, but a more than twofold increased risk of developing a severe infection or a fatal outcome. They should therefore be prioritized for vaccination, antiviral therapy and other appropriate treatment to mitigate hospitalization and death.", "doi": "10.1111/joim.13731", "pmid": "37850585", "labels": {"Funder: VR": null, "Funder: Forte": null, "Funder: KAW/SciLifeLab": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:32:09.046Z", "modified": "2023-11-01T13:54:10.428Z"}, {"entity": "publication", "iuid": "5cf9ff158e0c48febb96b8790d6544ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5cf9ff158e0c48febb96b8790d6544ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5cf9ff158e0c48febb96b8790d6544ae"}}, "title": "Age, Successive Waves, Immunization, and Mortality in Elderly COVID-19 Haematological Patients: EPICOVIDEHA Findings.", "authors": [{"family": "Rossi", "given": "Giuseppe", "initials": "G"}, {"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J"}, {"family": "Cattaneo", "given": "Chiara", "initials": "C"}, {"family": "Marchesi", "given": "Francesco", "initials": "F"}, {"family": "D\u00e1vila-Valls", "given": "Julio", "initials": "J"}, {"family": "Mart\u00edn-P\u00e9rez", "given": "Sonia", "initials": "S"}, {"family": "Itri", "given": "Federico", "initials": "F"}, {"family": "L\u00f3pez-Garc\u00eda", "given": "Alberto", "initials": "A"}, {"family": "Glenth\u00f8j", "given": "Andreas", "initials": "A"}, {"family": "Silva", "given": "Maria Gomes DA", "initials": "MGD"}, {"family": "Besson", "given": "Caroline", "initials": "C"}, {"family": "Marchetti", "given": "Monia", "initials": "M"}, {"family": "Weinbergerov\u00e1", "given": "Barbora", "initials": "B"}, {"family": "Jaksic", "given": "Ozren", "initials": "O"}, {"family": "Jim\u00e9nez", "given": "Moraima", "initials": "M"}, {"family": "Bilgin", "given": "Yavuz M", "initials": "YM"}, {"family": "Doesum", "given": "Jaap VAN", "initials": "JV"}, {"family": "Farina", "given": "Francesca", "initials": "F"}, {"family": "\u017d\u00e1k", "given": "Pavel", "initials": "P"}, {"family": "Verga", "given": "Luisa", "initials": "L"}, {"family": "Collins", "given": "Graham P", "initials": "GP"}, {"family": "Bonuomo", "given": "Valentina", "initials": "V"}, {"family": "Praet", "given": "Jens VAN", "initials": "JV"}, {"family": "Nucci", "given": "Marcio", "initials": "M"}, {"family": "Meers", "given": "Stef", "initials": "S"}, {"family": "Espigado", "given": "Ildefonso", "initials": "I"}, {"family": "Fracchiolla", "given": "Nicola S", "initials": "NS"}, {"family": "Valkovi\u0107", "given": "Toni", "initials": "T"}, {"family": "Poulsen", "given": "Christian Bj\u00f8rn", "initials": "CB"}, {"family": "\u010colovi\u0107", "given": "Natasha", "initials": "N"}, {"family": "Dragonetti", "given": "Giulia", "initials": "G"}, {"family": "Ledoux", "given": "Marie-Pierre", "initials": "M"}, {"family": "Tascini", "given": "Carlo", "initials": "C"}, {"family": "Buquicchio", "given": "Caterina", "initials": "C"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Passamonti", "given": "Francesco", "initials": "F"}, {"family": "Machado", "given": "Marina", "initials": "M"}, {"family": "Labrador", "given": "Jorge", "initials": "J"}, {"family": "Duarte", "given": "Rafael F", "initials": "RF"}, {"family": "Sch\u00f6nlein", "given": "Martin", "initials": "M"}, {"family": "Prezioso", "given": "Lucia", "initials": "L"}, {"family": "Falces-Romero", "given": "Iker", "initials": "I"}, {"family": "Kulasekararaj", "given": "Austin", "initials": "A"}, {"family": "Garcia-Vidal", "given": "Carolina", "initials": "C"}, {"family": "Fern\u00e1ndez", "given": "Noem\u00ed", "initials": "N"}, {"family": "Abu-Zeinah", "given": "Ghaith", "initials": "G"}, {"family": "Ormazabal-V\u00e9lez", "given": "Irati", "initials": "I"}, {"family": "Ad\u017ei\u0107-Vuki\u010devi\u0107", "given": "Tatjana", "initials": "T"}, {"family": "Piukovics", "given": "Kl\u00e1ra", "initials": "K"}, {"family": "Stoma", "given": "Igor", "initials": "I"}, {"family": "Cuccaro", "given": "Annarosa", "initials": "A"}, {"family": "Magliano", "given": "Gabriele", "initials": "G"}, {"family": "Szotkowski", "given": "Tom\u00e1\u0161", "initials": "T"}, {"family": "Gonz\u00e1lez-L\u00f3pez", "given": "Tom\u00e1s-Jos\u00e9", "initials": "T"}, {"family": "El-Ashwah", "given": "Shaimaa", "initials": "S"}, {"family": "Bergantim", "given": "Rui", "initials": "R"}, {"family": "Sili", "given": "Uluhan", "initials": "U"}, {"family": "Maertens", "given": "Johan", "initials": "J"}, {"family": "Demirkan", "given": "Fatih", "initials": "F"}, {"family": "Ram\u00f3n", "given": "Cristina DE", "initials": "CD"}, {"family": "Petzer", "given": "Verena", "initials": "V"}, {"family": "Principe", "given": "Maria Ilaria Del", "initials": "MID"}, {"family": "Navr\u00e1til", "given": "Milan", "initials": "M"}, {"family": "Dargenio", "given": "Michelina", "initials": "M"}, {"family": "Seval", "given": "Guldane Cengiz", "initials": "GC"}, {"family": "Samarkos", "given": "Michail", "initials": "M"}, {"family": "R\u00e1\u010dil", "given": "Zden\u011bk", "initials": "Z"}, {"family": "Pincz\u00e9s", "given": "L\u00e1szl\u00f3 Imre", "initials": "LI"}, {"family": "Lahmer", "given": "Tobias", "initials": "T"}, {"family": "Busca", "given": "Alessandro", "initials": "A"}, {"family": "M\u00e9ndez", "given": "Gustavo-Adolfo", "initials": "G"}, {"family": "Vena", "given": "Antonio", "initials": "A"}, {"family": "Biernat", "given": "Monika M", "initials": "MM"}, {"family": "Merelli", "given": "Maria", "initials": "M"}, {"family": "Calbacho", "given": "Maria", "initials": "M"}, {"family": "Bara\u0107", "given": "Aleksandra", "initials": "A"}, {"family": "Bavastro", "given": "Martina", "initials": "M"}, {"family": "Limongelli", "given": "Alessandro", "initials": "A"}, {"family": "Ilhan", "given": "Osman", "initials": "O"}, {"family": "Wolf", "given": "Dominik", "initials": "D"}, {"family": "\u00c7olak", "given": "G\u00f6k\u00e7e Melis", "initials": "GM"}, {"family": "Garc\u00eda-Sanz", "given": "Ram\u00f3n", "initials": "R"}, {"family": "Emarah", "given": "Ziad", "initials": "Z"}, {"family": "Mi\u0161kovi\u0107", "given": "Bojana", "initials": "B"}, {"family": "Gr\u00e4fe", "given": "Stefanie", "initials": "S"}, {"family": "Mladenovi\u0107", "given": "Milo\u0161", "initials": "M"}, {"family": "Aiello", "given": "Tommaso Francesco", "initials": "TF"}, {"family": "N\u00fa\u00f1ez-Mart\u00edn-Buitrago", "given": "Luc\u00eda", "initials": "L"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Arellano", "given": "Elena", "initials": "E"}, {"family": "Zambrotta", "given": "Giovanni Paolo Maria", "initials": "GPM"}, {"family": "Ammatuna", "given": "Emanuele", "initials": "E"}, {"family": "Cabirta", "given": "Alba", "initials": "A"}, {"family": "Sacchi", "given": "Maria Vittoria", "initials": "MV"}, {"family": "Rodrigues", "given": "Raquel Nunes", "initials": "RN"}, {"family": "Hersby", "given": "Ditte Stampe", "initials": "DS"}, {"family": "Hanakova", "given": "Michaela", "initials": "M"}, {"family": "Rahimli", "given": "Laman", "initials": "L"}, {"family": "Cordoba", "given": "Raul", "initials": "R"}, {"family": "Cornely", "given": "Oliver A", "initials": "OA"}, {"family": "Pagano", "given": "Livio", "initials": "L"}], "type": "journal article", "published": "2023-10-18", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": null, "issue": null, "pages": null}, "abstract": "Elderly patients with haematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection impact in different age groups remains unstudied in detail.\r\n\r\nWe analysed elderly patients (age groups: 65-70, 71-75, 76-80 and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with haematological malignancy.\r\n\r\nThe study included data from 3,603 elderly patients (aged 65 or older) with haematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukaemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment.\r\n\r\nThese data underscore the heterogeneity of elderly haematological patients, highlight the different impact of COVID waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts.", "doi": "10.1016/j.ijid.2023.10.013", "pmid": "37863310", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(23)00749-X"}], "notes": [], "created": "2023-11-01T13:33:15.755Z", "modified": "2023-11-02T07:16:55.345Z"}, {"entity": "publication", "iuid": "44585b5eb5754910bf3b4e4c6b78b8b8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44585b5eb5754910bf3b4e4c6b78b8b8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44585b5eb5754910bf3b4e4c6b78b8b8"}}, "title": "SARS-CoV-2 evolution in the Omicron era.", "authors": [{"family": "Roemer", "given": "Cornelius", "initials": "C", "orcid": "0000-0002-6138-6539", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cd1cc85b51147fd8aeef3e206f995b3.json"}}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ", "orcid": "0000-0002-0227-5636", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a612a313d5874131ba64d9811a5d4a08.json"}}, {"family": "Hisner", "given": "Ryan", "initials": "R", "orcid": "0000-0001-8296-9373", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73c65e0c64794ba4a6ada6cf6d927102.json"}}, {"family": "Gueli", "given": "Federico", "initials": "F"}, {"family": "Sakaguchi", "given": "Hitoshi", "initials": "H"}, {"family": "Frohberg", "given": "Nicholas", "initials": "N"}, {"family": "Schoenmakers", "given": "Josette", "initials": "J"}, {"family": "Sato", "given": "Kenta", "initials": "K"}, {"family": "O'Toole", "given": "\u00c1ine", "initials": "\u00c1", "orcid": "0000-0001-8083-474X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4faf78c4ee04495b98b3fd8ef32a0a78.json"}}, {"family": "Rambaut", "given": "Andrew", "initials": "A", "orcid": "0000-0003-4337-3707", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d25e62e17c243f3ab72304ca504e296.json"}}, {"family": "Pybus", "given": "Oliver G", "initials": "OG"}, {"family": "Ruis", "given": "Christopher", "initials": "C", "orcid": "0000-0003-0977-5534", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02edb07284dc438b883cb404c615942f.json"}}, {"family": "Murrell", "given": "Ben", "initials": "B", "orcid": "0000-0002-0393-4445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60dac9ecf84d4eb3b90fb4ee1298bc52.json"}}, {"family": "Peacock", "given": "Thomas P", "initials": "TP", "orcid": "0000-0001-7077-2928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/940835adb42b431a882f9af9acf166f7.json"}}], "type": "journal article", "published": "2023-10-16", "journal": {"title": "Nat Microbiol", "issn": "2058-5276", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Since SARS-CoV-2 BA.5 (Omicron) emerged and spread in 2022, Omicron lineages have markedly diversified. Here we review the evolutionary trajectories and processes that underpin the emergence of these lineages, and identify the most prevalent sublineages. We discuss the potential origins of second-generation BA.2 lineages. Simple and complex recombination, antigenic drift and convergent evolution have enabled SARS-CoV-2 to accumulate mutations that alter its antigenicity. We also discuss the potential evolutionary trajectories of SARS-CoV-2 in the future.", "doi": "10.1038/s41564-023-01504-w", "pmid": "37845314", "labels": {"Category: Genomics & transcriptomics": null, "Type: Other": null, "Funder: KAW/SciLifeLab": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41564-023-01504-w"}], "notes": [], "created": "2023-11-01T13:33:52.276Z", "modified": "2023-11-02T07:30:16.619Z"}, {"entity": "publication", "iuid": "980940116302415bb1ddd8726ee46d69", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/980940116302415bb1ddd8726ee46d69.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/980940116302415bb1ddd8726ee46d69"}}, "title": "EuCARE-hospitalised study protocol: a cohort study of patients hospitalised with COVID-19 in the EuCARE project.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P"}, {"family": "Varisco", "given": "Benedetta", "initials": "B"}, {"family": "Bai", "given": "Francesca", "initials": "F"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Naucler", "given": "Pontus", "initials": "P"}, {"family": "Pfeifer", "given": "Nico", "initials": "N"}, {"family": "Cozzi-Lepri", "given": "Alessandro", "initials": "A"}, {"family": "Ceccherini-Silberstein", "given": "Francesca", "initials": "F"}, {"family": "Naumovas", "given": "Daniel", "initials": "D"}, {"family": "Drobniewski", "given": "Francis", "initials": "F"}, {"family": "Jensen", "given": "Bj\u00f6rn-Erik Ole", "initials": "BO"}, {"family": "Toscano", "given": "Cristina", "initials": "C"}, {"family": "Parczewski", "given": "Mi\u0142osz", "initials": "M"}, {"family": "Quintanares", "given": "Gibran Horemheb Rubio", "initials": "GHR"}, {"family": "Mwau", "given": "Matilu", "initials": "M"}, {"family": "Pinto", "given": "Jorge A", "initials": "JA"}, {"family": "Incardona", "given": "Francesca", "initials": "F"}, {"family": "Mommo", "given": "Chiara", "initials": "C"}, {"family": "Marchetti", "given": "Giulia", "initials": "G"}], "type": "clinical trial protocol", "published": "2023-10-16", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "issn-l": null, "volume": "23", "issue": "1", "pages": "690"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), can lead to hospitalisation, particularly in elderly, immunocompromised, and non-vaccinated or partially vaccinated individuals. Although vaccination provides protection, the duration of this protection wanes over time. Additional doses can restore immunity, but the influence of viral variants, specific sequences, and vaccine-induced immune responses on disease severity remains unclear. Moreover, the efficacy of therapeutic interventions during hospitalisation requires further investigation. The study aims to analyse the clinical course of COVID-19 in hospitalised patients, taking into account SARS-CoV-2 variants, viral sequences, and the impact of different vaccines. The primary outcome is all-cause in-hospital mortality, while secondary outcomes include admission to intensive care unit and length of stay, duration of hospitalisation, and the level of respiratory support required.\r\n\r\nThis ongoing multicentre study observes hospitalised adult patients with confirmed SARS-CoV-2 infection, utilising a combination of retrospective and prospective data collection. It aims to gather clinical and laboratory variables from around 35,000 patients, with potential for a larger sample size. Data analysis will involve biostatistical and machine-learning techniques. Selected patients will provide biological material. The study started on October 14, 2021 and is scheduled to end on October 13, 2026.\r\n\r\nThe analysis of a large sample of retrospective and prospective data about the acute phase of SARS CoV-2 infection in hospitalised patients, viral variants and vaccination in several European and non-European countries will help us to better understand risk factors for disease severity and the interplay between SARS CoV-2 variants, immune responses and vaccine efficacy. The main strengths of this study are the large sample size, the long study duration covering different waves of COVID-19 and the collection of biological samples that allows future research.\r\n\r\nThe trial has been registered on ClinicalTrials.gov. The unique identifier assigned to this trial is NCT05463380.", "doi": "10.1186/s12879-023-08658-2", "pmid": "37845624", "labels": {"Category: Health": null, "Funder: H2020": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10580565"}, {"db": "pii", "key": "10.1186/s12879-023-08658-2"}, {"db": "ClinicalTrials.gov", "key": "NCT05463380"}], "notes": [], "created": "2023-11-01T13:31:41.491Z", "modified": "2023-11-01T13:45:05.813Z"}, {"entity": "publication", "iuid": "2045217c9d5b4df2968b59d7905ac27e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2045217c9d5b4df2968b59d7905ac27e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2045217c9d5b4df2968b59d7905ac27e"}}, "title": "Design, structure and plasma binding of ancestral \u03b2-CoV scaffold antigens.", "authors": [{"family": "Hueting", "given": "David", "initials": "D"}, {"family": "Schriever", "given": "Karen", "initials": "K", "orcid": "0000-0002-3677-5508", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/437c22b7bd0344bfa62968e70d0a9ddf.json"}}, {"family": "Sun", "given": "Rui", "initials": "R"}, {"family": "Vlachiotis", "given": "Stelios", "initials": "S"}, {"family": "Zuo", "given": "Fanglei", "initials": "F", "orcid": "0000-0002-4545-1265", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11312f803b4f49d6be77684a634b0caf.json"}}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Persson", "given": "Helena", "initials": "H"}, {"family": "Hofstr\u00f6m", "given": "Camilla", "initials": "C"}, {"family": "Ohlin", "given": "Mats", "initials": "M", "orcid": "0000-0002-5105-1938", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/def6c0678dfd48ea9a1255a8a00e7ebc.json"}}, {"family": "Walld\u00e9n", "given": "Karin", "initials": "K"}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Marcotte", "given": "Harold", "initials": "H", "orcid": "0000-0002-7168-349X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e05b7b044674cc08cd2269ccf8c076e.json"}}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q", "orcid": "0000-0003-1990-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94a32366862b470eba3a15521b9be290.json"}}, {"family": "Andr\u00e9ll", "given": "Juni", "initials": "J", "orcid": "0000-0003-2313-9155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4088371e089f452783d302617a7fac91.json"}}, {"family": "Syr\u00e9n", "given": "Per-Olof", "initials": "P"}], "type": "journal article", "published": "2023-10-16", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "14", "issue": "1", "pages": "6527"}, "abstract": "We report the application of ancestral sequence reconstruction on coronavirus spike protein, resulting in stable and highly soluble ancestral scaffold antigens (AnSAs). The AnSAs interact with plasma of patients recovered from COVID-19 but do not bind to the human angiotensin-converting enzyme 2 (ACE2) receptor. Cryo-EM analysis of the AnSAs yield high resolution structures (2.6-2.8 \u00c5) indicating a closed pre-fusion conformation in which all three receptor-binding domains (RBDs) are facing downwards. The structures reveal an intricate hydrogen-bonding network mediated by well-resolved loops, both within and across monomers, tethering the N-terminal domain and RBD together. We show that AnSA-5 can induce and boost a broad-spectrum immune response against the wild-type RBD as well as circulating variants of concern in an immune organoid model derived from tonsils. Finally, we highlight how AnSAs are potent scaffolds by replacing the ancestral RBD with the wild-type sequence, which restores ACE2 binding and increases the interaction with convalescent plasma.", "doi": "10.1038/s41467-023-42200-x", "pmid": "37845250", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC10579346"}, {"db": "pii", "key": "10.1038/s41467-023-42200-x"}], "notes": [], "created": "2023-11-01T13:33:34.835Z", "modified": "2023-11-02T14:11:11.290Z"}, {"entity": "publication", "iuid": "9e6701a55fc64fdf88baada957443056", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9e6701a55fc64fdf88baada957443056.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9e6701a55fc64fdf88baada957443056"}}, "title": "Boosted production of antibodies which neutralized different SARS-CoV-2 variants in a COVID-19 convalescent following mRNA vaccination - a case study.", "authors": [{"family": "Ravlo", "given": "Erlend", "initials": "E"}, {"family": "Ianevski", "given": "Aleksandr", "initials": "A"}, {"family": "Starheim", "given": "Eirin", "initials": "E"}, {"family": "Wang", "given": "Wei", "initials": "W"}, {"family": "Ji", "given": "Ping", "initials": "P"}, {"family": "Lysvand", "given": "Hilde", "initials": "H"}, {"family": "Smura", "given": "Teemu", "initials": "T"}, {"family": "Kivi", "given": "Gaily", "initials": "G"}, {"family": "Voolaid", "given": "Maia-Liisa", "initials": "M"}, {"family": "Plaan", "given": "Kati", "initials": "K"}, {"family": "Ustav", "given": "Mart", "initials": "M"}, {"family": "Zusinaite", "given": "Eva", "initials": "E"}, {"family": "Tenson", "given": "Tanel", "initials": "T"}, {"family": "Kurg", "given": "Reet", "initials": "R"}, {"family": "Oksenych", "given": "Valentyn", "initials": "V"}, {"family": "Walstad", "given": "Kirsti", "initials": "K"}, {"family": "Nordb\u00f8", "given": "Svein Arne", "initials": "SA"}, {"family": "Kaarb\u00f8", "given": "Mari", "initials": "M"}, {"family": "Ernits", "given": "Karin", "initials": "K"}, {"family": "Bj\u00f8r\u00e5s", "given": "Magnar", "initials": "M"}, {"family": "Kainov", "given": "Denis E", "initials": "DE"}, {"family": "H\u00f8ys\u00e6ter Fenstad", "given": "Mona", "initials": "M"}], "type": "case reports", "published": "2023-10-16", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": null, "issue": null, "pages": null}, "abstract": "Vaccinated convalescents do not develop severe COVID-19 after infection with new SARS-CoV-2 variants. We questioned how mRNA vaccination of convalescents provides protection from emerging virus variant. From the cohort of 71 convalescent plasma donors, we identified a patient who developed immune response to infection with SARS-CoV-2 variant of 20A clade and who subsequently received mRNA vaccine encoding S protein of strain of 19A clade. We showed that vaccination increased the production of immune cells and anti-S antibodies in the serum. Serum antibodies neutralized not only 19A and 20A, but also 20B, 20H, 21J and 21K virus variants. One of the serum antibodies (100F8) completely neutralized 20A, 21J and partially 21K strains. 100F8 was structurally similarly to published Ab188 antibody, which recognized non-conserved epitope on the S protein. We proposed that 100F8 and other serum antibodies of the patient which recognized non- and conserved epitopes of the S protein, could have additive or synergistic effect to neutralize various virus variants. Thus, mRNA vaccination could be beneficial for convalescents because it boosts production of neutralizing antibodies with broad-spectrum activity. -.", "doi": "10.1016/j.ijid.2023.10.011", "pmid": "37852599", "labels": {"Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(23)00748-8"}], "notes": [], "created": "2023-11-01T13:32:11.722Z", "modified": "2023-11-01T13:55:02.083Z"}, {"entity": "publication", "iuid": "0444ca3518ef4347aed3ff1988d9f5b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0444ca3518ef4347aed3ff1988d9f5b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0444ca3518ef4347aed3ff1988d9f5b2"}}, "title": "Measures against COVID-19 affected the spread of human enteric viruses in a Swedish community, as found when monitoring wastewater.", "authors": [{"family": "Wang", "given": "Hao", "initials": "H"}, {"family": "Churqui", "given": "Marianela Patzi", "initials": "MP"}, {"family": "Tunovic", "given": "Timur", "initials": "T"}, {"family": "Enache", "given": "Lucica", "initials": "L"}, {"family": "Johansson", "given": "Anette", "initials": "A"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Norder", "given": "Hel\u00e9ne", "initials": "H"}], "type": "journal article", "published": "2023-10-15", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "issn-l": "0048-9697", "volume": "895", "issue": null, "pages": "165012"}, "abstract": "The quantification of viral genomes in wastewater reflects the prevalence of viral infections within the community. Knowledge of how the spread of common enteric viruses in the community was affected by the Swedish COVID-19 interventions is limited. To investigate this, the weekly wastewater samples collected for monitoring SARS-CoV-2 throughout the COVID-19 pandemic at the Rya sewage treatment plant in Gothenburg were also analyzed for adenovirus, norovirus GII, astrovirus, and rotavirus. The amount of each viral genome was quantified by real-time-qPCR and compared with the quantity of these viral genomes in wastewater from 2017. The results showed that the winter seasonality of norovirus GII and rotavirus in wastewater observed in 2017 was interrupted shortly after the introduction of the COVID-19 interventions, and they remained at low level throughout the pandemic. The circulation pattern of astrovirus and adenovirus was less affected. When the COVID-19 restrictions were lifted in 2022, a dramatic increase was observed in the amount of norovirus GII, rotavirus, and adenovirus genomes in wastewater. The changes in abundance and seasonality of some viruses identified through wastewater monitoring were consistent with changes in the number of patients diagnosed with these viruses. These findings suggest that moderate intervention to prevent COVID-19 significantly reduced the spread of some enteric viruses in the community. The results show that wastewater monitoring is a valuable tool for detecting the spread and outbreaks of viral infections that may cause gastroenteritis also when people do not seek medical help, such as during the COVID-19 pandemic.", "doi": "10.1016/j.scitotenv.2023.165012", "pmid": "37353026", "labels": {"Category: Public Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10284612"}, {"db": "pii", "key": "S0048-9697(23)03635-5"}], "notes": [], "created": "2023-10-04T09:29:53.367Z", "modified": "2023-10-04T09:41:30.000Z"}, {"entity": "publication", "iuid": "3760d53d668c48d4a6913a27074e84b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3760d53d668c48d4a6913a27074e84b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3760d53d668c48d4a6913a27074e84b9"}}, "title": "Umbilical cord clamping in the early phases of the COVID-19 era - A systematic review and meta-analysis of reported practice and recommendations in guidelines.", "authors": [{"family": "Berg", "given": "Johan", "initials": "J"}, {"family": "Thies-Lagergren", "given": "Li", "initials": "L"}, {"family": "Svedenkrans", "given": "Jenny", "initials": "J"}, {"family": "Samkutty", "given": "Jeremiah", "initials": "J"}, {"family": "Larsson", "given": "Sara Marie", "initials": "SM"}, {"family": "Mercer", "given": "Judith S", "initials": "JS"}, {"family": "Rabe", "given": "Heike", "initials": "H"}, {"family": "Andersson", "given": "Ola", "initials": "O"}, {"family": "Zaigham", "given": "Mehreen", "initials": "M"}], "type": "journal article", "published": "2023-10-13", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": null, "issue": null, "pages": null}, "abstract": "In the beginning of the COVID-19 pandemic, delayed umbilical cord clamping (CC) at birth may have been commonly discouraged despite a lack of convincing evidence of mother-to-neonate SARS-CoV-2 transmission. We aimed to systematically review guidelines, reports of practice and to analyze associations between timing of cord clamping and mother-to-neonate SARS-CoV-2 transmission during the early phases of the pandemic.\r\n\r\nMajor databases were searched December 1, 2019 to July 20, 2021.\r\n\r\nstudies and guidelines describing cord clamping practice in women with SARS-CoV-2 infection during pregnancy until two postnatal days, giving birth to live born neonates.\r\n\r\nno extractable data. Two reviewers independently screened studies for eligibility and assessed study quality. Pooled prevalence rates were calculated.\r\n\r\nForty-eight studies (1476 neonates) and 40 guidelines were included. Delayed CC was recommended in 70.0% of the guidelines. Nevertheless, delayed CC was reported less often than early CC: 262/1476 (17.8%) vs. 511/1476 (34.6%). Neonatal SARS-CoV-2 positivity rates were similar following delayed (1.2%) and early CC (1.3%). Most SARS-CoV-2 transmissions (93.3%) occurred in utero.\r\n\r\nDelayed CC did not seem to increase mother-to-neonate SARS-CoV-2 transmission. Due to its benefits, it should be encouraged even in births where the mother has a SARS-CoV-2 infection.", "doi": "10.1016/j.ijid.2023.10.010", "pmid": "37839504", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(23)00747-6"}], "notes": [], "created": "2023-11-01T13:31:51.574Z", "modified": "2023-11-01T13:49:55.161Z"}, {"entity": "publication", "iuid": "041ca07d2c3b4051a87a5ad6910b6b2f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/041ca07d2c3b4051a87a5ad6910b6b2f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/041ca07d2c3b4051a87a5ad6910b6b2f"}}, "title": "A community effort in SARS-CoV-2 drug discovery.", "authors": [{"family": "Schimunek", "given": "Johannes", "initials": "J"}, {"family": "Seidl", "given": "Philipp", "initials": "P"}, {"family": "Elez", "given": "Katarina", "initials": "K"}, {"family": "Hempel", "given": "Tim", "initials": "T"}, {"family": "Le", "given": "Tuan", "initials": "T"}, {"family": "No\u00e9", "given": "Frank", "initials": "F"}, {"family": "Olsson", "given": "Simon", "initials": "S"}, {"family": "Raich", "given": "Llu\u00eds", "initials": "L"}, {"family": "Winter", "given": "Robin", "initials": "R"}, {"family": "Gokcan", "given": "Hatice", "initials": "H"}, {"family": "Gusev", "given": "Filipp", "initials": "F"}, {"family": "Gutkin", "given": "Evgeny M", "initials": "EM"}, {"family": "Isayev", "given": "Olexandr", "initials": "O"}, {"family": "Kurnikova", "given": "Maria G", "initials": "MG"}, {"family": "Narangoda", "given": "Chamali H", "initials": "CH"}, {"family": "Zubatyuk", "given": "Roman", "initials": "R"}, {"family": "Bosko", "given": "Ivan P", "initials": "IP"}, {"family": "Furs", "given": "Konstantin V", "initials": "KV"}, {"family": "Karpenko", "given": "Anna D", "initials": "AD"}, {"family": "Kornoushenko", "given": "Yury V", "initials": "YV"}, {"family": "Shuldau", "given": "Mikita", "initials": "M"}, {"family": "Yushkevich", "given": "Artsemi", "initials": "A"}, {"family": "Benabderrahmane", "given": "Mohammed", "initials": "M"}, {"family": "Bousquet-Melou", "given": "Patrick", "initials": "P"}, {"family": "Bureau", "given": "Ronan", "initials": "R"}, {"family": "Charton", "given": "Beatrice", "initials": "B"}, {"family": "Cirou", "given": "Bertrand", "initials": "B"}, {"family": "Gil", "given": "G\u00e9rard", "initials": "G"}, {"family": "Allen", "given": "William J", "initials": "WJ"}, {"family": "Sirimulla", "given": "Suman", "initials": "S"}, {"family": "Watowich", "given": "Stanley", "initials": "S"}, {"family": "Antonopoulos", "given": "Nick", "initials": "N"}, {"family": "Epitropakis", "given": "Nikolaos", "initials": "N"}, {"family": "Krasoulis", "given": "Agamemnon", "initials": "A"}, {"family": "Pitsikalis", "given": "Vassilis", "initials": "V"}, {"family": "Theodorakis", "given": "Stavros", "initials": "S"}, {"family": "Kozlovskii", "given": "Igor", "initials": "I"}, {"family": "Maliutin", "given": "Anton", "initials": "A"}, {"family": "Medvedev", "given": "Alexander", "initials": "A"}, {"family": "Popov", "given": "Petr", "initials": "P"}, {"family": "Zaretckii", "given": "Mark", "initials": "M"}, {"family": "Eghbal-Zadeh", "given": "Hamid", "initials": "H"}, {"family": "Halmich", "given": "Christina", "initials": "C"}, {"family": "Hochreiter", "given": "Sepp", "initials": "S"}, {"family": "Mayr", "given": "Andreas", "initials": "A"}, {"family": "Ruch", "given": "Peter", "initials": "P"}, {"family": "Widrich", "given": "Michael", "initials": "M"}, {"family": "Berenger", "given": "Francois", "initials": "F"}, {"family": "Kumar", "given": "Ashutosh", "initials": "A"}, {"family": "Yamanishi", "given": "Yoshihiro", "initials": "Y"}, {"family": "Zhang", "given": "Kam", "initials": "K"}, {"family": "Bengio", "given": "Emmanuel", "initials": "E"}, {"family": "Bengio", "given": "Yoshua", "initials": "Y"}, {"family": "Jain", "given": "Moksh", "initials": "M"}, {"family": "Korablyov", "given": "Maksym", "initials": "M"}, {"family": "Liu", "given": "Cheng-Hao", "initials": "CH"}, {"family": "Gilles", "given": "Marcous", "initials": "M"}, {"family": "Glaab", "given": "Enrico", "initials": "E"}, {"family": "Barnsley", "given": "Kelly", "initials": "K"}, {"family": "Iyengar", "given": "Suhasini M", "initials": "SM"}, {"family": "Ondrechen", "given": "Mary Jo", "initials": "MJ"}, {"family": "Haupt", "given": "V Joachim", "initials": "VJ"}, {"family": "Kaiser", "given": "Florian", "initials": "F"}, {"family": "Schroeder", "given": "Michael", "initials": "M"}, {"family": "Pugliese", "given": "Luisa", "initials": "L"}, {"family": "Albani", "given": "Simone", "initials": "S"}, {"family": "Athanasiou", "given": "Christina", "initials": "C"}, {"family": "Beccari", "given": "Andrea", "initials": "A"}, {"family": "Carloni", "given": "Paolo", "initials": "P"}, {"family": "D'Arrigo", "given": "Giulia", "initials": "G"}, {"family": "Gianquinto", "given": "Eleonora", "initials": "E"}, {"family": "Go\u00dfen", "given": "Jonas", "initials": "J"}, {"family": "Hanke", "given": "Anton", "initials": "A"}, {"family": "Joseph", "given": "Benjamin P", "initials": "BP"}, {"family": "Kokh", "given": "Daria B", "initials": "DB"}, {"family": "Kovachka", "given": "Sandra", "initials": "S"}, {"family": "Manelfi", "given": "Candida", "initials": "C"}, {"family": "Mukherjee", "given": "Goutam", "initials": "G"}, {"family": "Mu\u00f1iz-Chicharro", "given": "Abraham", "initials": "A"}, {"family": "Musiani", "given": "Francesco", "initials": "F"}, {"family": "Nunes-Alves", "given": "Ariane", "initials": "A"}, {"family": "Paiardi", "given": "Giulia", "initials": "G"}, {"family": "Rossetti", "given": "Giulia", "initials": "G"}, {"family": "Sadiq", "given": "S Kashif", "initials": "SK"}, {"family": "Spyrakis", "given": "Francesca", "initials": "F"}, {"family": "Talarico", "given": "Carmine", "initials": "C"}, {"family": "Tsengenes", "given": "Alexandros", "initials": "A"}, {"family": "Wade", "given": "Rebecca", "initials": "R"}, {"family": "Copeland", "given": "Conner", "initials": "C"}, {"family": "Gaiser", "given": "Jeremiah", "initials": "J"}, {"family": "Olson", "given": "Daniel R", "initials": "DR"}, {"family": "Roy", "given": "Amitava", "initials": "A"}, {"family": "Venkatraman", "given": "Vishwesh", "initials": "V"}, {"family": "Wheeler", "given": "Travis J", "initials": "TJ"}, {"family": "Arthanari", "given": "Haribabu", "initials": "H"}, {"family": "Blaschitz", "given": "Klara", "initials": "K"}, {"family": "Cespugli", "given": "Marco", "initials": "M"}, {"family": "Durmaz", "given": "Vedat", "initials": "V"}, {"family": "Fackeldey", "given": "Konstantin", "initials": "K"}, {"family": "Fischer", "given": "Patrick D", "initials": "PD"}, {"family": "Gorgulla", "given": "Christoph", "initials": "C"}, {"family": "Gruber", "given": "Christian", "initials": "C"}, {"family": "Gruber", "given": "Karl", "initials": "K"}, {"family": "Hetmann", "given": "Michael", "initials": "M"}, {"family": "Kinney", "given": "Jamie E", "initials": "JE"}, {"family": "Das", "given": "Krishna M Padmanabha", "initials": "KMP"}, {"family": "Pandita", "given": "Shreya", "initials": "S"}, {"family": "Singh", "given": "Amit", "initials": "A"}, {"family": "Steinkellner", "given": "Georg", "initials": "G"}, {"family": "Tesseyre", "given": "Guilhem", "initials": "G"}, {"family": "Wagner", "given": "Gerhard", "initials": "G"}, {"family": "Wang", "given": "Zi-Fu", "initials": "ZF"}, {"family": "Yust", "given": "Ryan J", "initials": "RJ"}, {"family": "Druzhilovskiy", "given": "Dmitry S", "initials": "DS"}, {"family": "Filimonov", "given": "Dmitry", "initials": "D"}, {"family": "Pogodin", "given": "Pavel V", "initials": "PV"}, {"family": "Poroikov", "given": "Vladimir", "initials": "V"}, {"family": "Rudik", "given": "Anastassia V", "initials": "AV"}, {"family": "Stolbov", "given": "Leonid A", "initials": "LA"}, {"family": "Veselovsky", "given": "Alexander V", "initials": "AV"}, {"family": "De Rosa", "given": "Maria", "initials": "M"}, {"family": "Simone", "given": "Giada De", "initials": "G"}, {"family": "Gulotta", "given": "Maria R", "initials": "MR"}, {"family": "Lombino", "given": "Jessica", "initials": "J"}, {"family": "Mekni", "given": "Nedra", "initials": "N"}, {"family": "Perricone", "given": "Ugo", "initials": "U"}, {"family": "Casini", "given": "Arturo", "initials": "A"}, {"family": "Embree", "given": "Amanda", "initials": "A"}, {"family": "Gordon", "given": "D Benjamin", "initials": "DB"}, {"family": "Lei", "given": "David", "initials": "D"}, {"family": "Pratt", "given": "Katelin", "initials": "K"}, {"family": "Voigt", "given": "Christopher A", "initials": "CA"}, {"family": "Chen", "given": "Kuang-Yu", "initials": "KY"}, {"family": "Jacob", "given": "Yves", "initials": "Y"}, {"family": "Krischuns", "given": "Tim", "initials": "T"}, {"family": "Lafaye", "given": "Pierre", "initials": "P"}, {"family": "Zettor", "given": "Agn\u00e8s", "initials": "A"}, {"family": "Rodr\u00edguez", "given": "M Luis", "initials": "ML"}, {"family": "White", "given": "Kris M", "initials": "KM"}, {"family": "Fearon", "given": "Daren", "initials": "D"}, {"family": "von Delft", "given": "Frank", "initials": "F"}, {"family": "Walsh", "given": "Martin A", "initials": "MA"}, {"family": "Horvath", "given": "Dragos", "initials": "D"}, {"family": "Brooks", "given": "Charles L", "initials": "CL"}, {"family": "Falsafi", "given": "Babak", "initials": "B"}, {"family": "Ford", "given": "Bryan", "initials": "B"}, {"family": "Garc\u00eda-Sastre", "given": "Adolfo", "initials": "A"}, {"family": "Lee", "given": "Sang Yup", "initials": "SY"}, {"family": "Naffakh", "given": "Nadia", "initials": "N"}, {"family": "Varnek", "given": "Alexandre", "initials": "A"}, {"family": "Klambauer", "given": "Guenter", "initials": "G"}, {"family": "Hermans", "given": "Thomas M", "initials": "TM"}], "type": "journal article", "published": "2023-10-13", "journal": {"title": "Mol Inform", "issn": "1868-1751", "issn-l": null}, "abstract": "The COVID-19 pandemic continues to pose a substantial threat to human lives and is likely to do so for years to come. Despite the availability of vaccines, searching for efficient small-molecule drugs that are widely available, including in low- and middle-income countries, is an ongoing challenge. In this work, we report the results of an open science community effort, the \"Billion molecules against Covid-19 challenge\", to identify small-molecule inhibitors against SARS-CoV-2 or relevant human receptors. Participating teams used a wide variety of computational methods to screen a minimum of 1 billion virtual molecules against 6 protein targets. Overall, 31 teams participated, and they suggested a total of 639,024 molecules, which were subsequently ranked to find 'consensus compounds'. The organizing team coordinated with various contract research organizations (CROs) and collaborating institutions to synthesize and test 878 compounds for biological activity against proteases (Nsp5, Nsp3, TMPRSS2), nucleocapsid N, RdRP (only the Nsp12 domain), and (alpha) spike protein S. Overall, 27 compounds with weak inhibition/binding were experimentally identified by binding-, cleavage-, and/or viral suppression assays and are presented here. Open science approaches such as the one presented here contribute to the knowledge base of future drug discovery efforts in finding better SARS-CoV-2 treatments.", "doi": "10.1002/minf.202300262", "pmid": "37833243", "labels": [], "xrefs": [], "notes": [], "created": "2023-11-01T13:31:54.098Z", "modified": "2023-11-01T13:31:54.163Z"}, {"entity": "publication", "iuid": "f28d86a7fc294a118412007f577700be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f28d86a7fc294a118412007f577700be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f28d86a7fc294a118412007f577700be"}}, "title": "Obstetric Intervention and Perinatal Outcomes During the Coronavirus Disease 2019 (COVID-19) Pandemic.", "authors": [{"family": "Simon", "given": "Sophie", "initials": "S"}, {"family": "John", "given": "Sid", "initials": "S"}, {"family": "Lisonkova", "given": "Sarka", "initials": "S"}, {"family": "Razaz", "given": "Neda", "initials": "N"}, {"family": "Muraca", "given": "Giulia M", "initials": "GM"}, {"family": "Boutin", "given": "Am\u00e9lie", "initials": "A"}, {"family": "Bedaiwy", "given": "Mohamed A", "initials": "MA"}, {"family": "Brandt", "given": "Justin S", "initials": "JS"}, {"family": "Ananth", "given": "Cande V", "initials": "CV"}, {"family": "Joseph", "given": "K S", "initials": "KS"}], "type": "journal article", "published": "2023-10-12", "journal": {"title": "Obstet Gynecol", "issn": "1873-233X", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To quantify pandemic-related changes in obstetric intervention and perinatal outcomes in the United States.\r\n\r\nWe carried out a retrospective study of all live births and fetal deaths in the United States, 2015-2021, with data obtained from the natality, fetal death, and linked live birth-infant death files of the National Center for Health Statistics. Analyses were carried out among all singletons; singletons of patients with prepregnancy diabetes, prepregnancy hypertension, and hypertensive disorders of pregnancy; and twins. Outcomes of interest included preterm birth, preterm labor induction or preterm cesarean delivery, macrosomia, postterm birth, and perinatal death. Interrupted time series analyses were used to estimate changes in the prepandemic period (January 2015-February 2020), at pandemic onset (March 2020), and in the pandemic period (March 2020-December 2021).\r\n\r\nThe study population included 26,604,392 live births and 155,214 stillbirths. The prepandemic period was characterized by temporal increases in preterm birth and preterm labor induction or cesarean delivery rates and temporal reductions in macrosomia, postterm birth, and perinatal mortality. Pandemic onset was associated with absolute decreases in preterm birth (decrease of 0.322/100 live births, 95% CI 0.506-0.139) and preterm labor induction or cesarean delivery (decrease of 0.190/100 live births, 95% CI 0.334-0.047) and absolute increases in macrosomia (increase of 0.046/100 live births), postterm birth (increase of 0.015/100 live births), and perinatal death (increase of 0.501/1,000 total births, 95% CI 0.220-0.783). These changes were larger in subpopulations at high risk (eg, among singletons of patients with prepregnancy diabetes). Among singletons of patients with prepregnancy diabetes, pandemic onset was associated with a decrease in preterm birth (decrease of 1.634/100 live births) and preterm labor induction or cesarean delivery (decrease of 1.521/100 live births) and increases in macrosomia (increase of 0.328/100 live births) and perinatal death (increase of 9.840/1,000 total births, 95% CI 3.933-15.75). Most changes were reversed in the months after pandemic onset.\r\n\r\nThe onset of the coronavirus disease 2019 (COVID-19) pandemic was associated with a transient decrease in obstetric intervention (especially preterm labor induction or cesarean delivery) and a transient increase in perinatal mortality.", "doi": "10.1097/AOG.0000000000005412", "pmid": "37826851", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "00006250-990000000-00925"}], "notes": [], "created": "2023-11-01T13:34:24.628Z", "modified": "2023-11-02T07:52:28.666Z"}, {"entity": "publication", "iuid": "1bc095eacf4642b386c0e6e595d6ec1f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1bc095eacf4642b386c0e6e595d6ec1f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1bc095eacf4642b386c0e6e595d6ec1f"}}, "title": "Persistent SARS-CoV-2 infection in patients with B-cell deficiency: a case series of successful antiviral treatment of four patients.", "authors": [{"family": "Fax\u00e9n", "given": "Lisa", "initials": "L"}, {"family": "Edvinsson", "given": "Marie", "initials": "M"}], "type": "case reports", "published": "2023-10-11", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "issn-l": "0300-9734", "volume": "128", "issue": null, "pages": null}, "abstract": "Persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in immunocompromised patients remains a major medical challenge. Diagnosing the syndrome is difficult as symptoms may mimic other diseases and treatment guidelines are lacking. We describe a case series of four patients with persistent SARS-CoV-2 infection that all had an underlying B-cell deficiency due to rituximab treatment (in one case in combination with epcoritamab). In all four patients, it was initially difficult to recognize the persistent disease, leading to a duration of illness between 45 and 242 days. Two patients were only positive for SARS-CoV-2 by polymerase chain reaction (PCR) in the nasopharynx at the beginning of the disease but were later repeatedly negative. However, when bronchoalveolar lavage was performed, a positive SARS-CoV-2 PCR was revealed from the lower airways in both patients. The difficulties establishing diagnosis contributed to these two patients' long disease course. The longest disease duration was in the patient treated with rituximab and epcoritamab, who also responded poorly to single standard antiviral treatment. This patient ultimately cleared the infection after administering a combination treatment with remdesivir and nirmatrelvir/ritonavir. After a confirmed diagnosis, the other three patients cleared the infection when they were finally treated with antivirals. Increasing clinicians' awareness of this condition is important as it might be treatable once diagnosed. Further studies are warranted to define the condition and treatment strategy with greater precision.", "doi": "10.48101/ujms.v128.9807", "pmid": "37849689", "labels": {"Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10578053"}, {"db": "pii", "key": "9807"}], "notes": [], "created": "2023-11-01T13:33:25.248Z", "modified": "2023-11-02T07:20:19.184Z"}, {"entity": "publication", "iuid": "634a7e09497f47248acffc706bc8c203", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/634a7e09497f47248acffc706bc8c203.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/634a7e09497f47248acffc706bc8c203"}}, "title": "Changing patterns in the burden of paediatric injuries during the COVID-19 pandemic: a study in Mozambique's central hospitals.", "authors": [{"family": "Amado", "given": "Vanda", "initials": "V", "orcid": "0000-0002-8839-984X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e564fcb429b45c8932476d0df8d086f.json"}}, {"family": "Trott", "given": "Sebastien", "initials": "S"}, {"family": "M\u00f6ller", "given": "Jette", "initials": "J"}, {"family": "Couto", "given": "Maria Tereza", "initials": "MT"}, {"family": "Wallis", "given": "Lee", "initials": "L"}, {"family": "Laflamme", "given": "Lucie", "initials": "L"}], "type": "journal article", "published": "2023-10-06", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "issn-l": null, "volume": "23", "issue": "1", "pages": "1071"}, "abstract": "There is a substantial body of knowledge on the effects of the COVID-19 pandemic on injuries showing frequent but inconsistent reductions in both volume and pattern. Yet, studies specifically addressing children are less common, not least from low- and middle-income countries. This study investigated whether changes in the pattern and outcome of paediatric injury admissions to Mozambique's four regional referral hospitals during 2020.\r\n\r\nClinical charts of paediatric patients presenting to the targeted hospitals with acute injuries were reviewed using a set of child, injury, and outcome characteristics during each of two consecutive restriction periods in 2020 using as a comparator the same periods in 2019, the year before the pandemic. Differences between 2020 and 2019 proportions for any characteristic were examined using the t-test (significance level 0.05).\r\n\r\nDuring both restriction periods, compared with the previous year, reductions in the number of injuries were noticed in nearly all aspects investigated, albeit more remarkably during the first restriction period, in particular, greater proportions of injuries in the home setting and from burns (7.2% and 11.5% respectively) and a reduced one of discharged patients (by 2.5%).\r\n\r\nDuring the restrictions implemented to contend the pandemic in Mozambique in 2020, although each restriction period saw a drop in the volume of injury admissions at central hospitals, the pattern of child, injury and outcome characteristics did not change much, except for an excess of home and burn injuries in the first, more restrictive period. Whether this reflects the nature of the restrictions only or, rather, other mechanisms that came into play, individual or health systems related, remains to be determined.", "doi": "10.1186/s12913-023-10073-x", "pmid": "37803444", "labels": {"Category: Social Science & Humanities": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10559493"}, {"db": "pii", "key": "10.1186/s12913-023-10073-x"}], "notes": [], "created": "2023-11-01T13:34:09.824Z", "modified": "2023-11-02T07:42:56.476Z"}, {"entity": "publication", "iuid": "0c9b00c1c1354d5a86afaba702538d56", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c9b00c1c1354d5a86afaba702538d56.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c9b00c1c1354d5a86afaba702538d56"}}, "title": "COVID-19 vaccine booster doses provide increased protection against COVID-19 hospitalization compared with previously vaccinated individuals: Interim findings from the REFORCO-Brazil real-world effectiveness study during Delta and Omicron.", "authors": [{"family": "Meeraus", "given": "Wilhelmine", "initials": "W"}, {"family": "Stuurman", "given": "Anke L", "initials": "AL"}, {"family": "Durukal", "given": "Ilgaz", "initials": "I"}, {"family": "Conde-Sousa", "given": "Eduardo", "initials": "E"}, {"family": "Lee", "given": "Andrew", "initials": "A"}, {"family": "Maria", "given": "Andr\u00e9 Santa", "initials": "AS"}, {"family": "Furtado", "given": "B\u00e1rbara Emoingt", "initials": "BE"}, {"family": "Ouwens", "given": "Mario", "initials": "M"}, {"family": "Gray", "given": "Christen M", "initials": "CM"}, {"family": "Valverde", "given": "Douglas Andreas", "initials": "DA"}, {"family": "da Silva", "given": "Hugo Gomes", "initials": "HG"}, {"family": "Taylor", "given": "Sylvia", "initials": "S"}], "type": "journal article", "published": "2023-10-06", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null, "volume": "41", "issue": "42", "pages": "6366-6378"}, "abstract": "Although COVID-19 booster vaccination is widely recommended, there is limited long-term, population-level, real-world evidence on the magnitude of improved protection against severe COVID-19 conferred by boosting with monovalent COVID-19 vaccines developed against ancestral SARS-CoV-2, especially in low- or middle-income countries. We present interim results from the first large-scale assessment of the relative vaccine effectiveness (rVE) of first and second booster doses against severe COVID-19 in a low-/middle-income country.\r\n\r\nREFORCO-Brazil is an ongoing, test-negative case-control study (NCT05697705) utilizing Brazil national severe acute respiratory syndrome (SARS) surveillance and vaccination data. In SARS hospitalizations from August 1, 2021 to July 31, 2022, we matched test-positive (via SARS-CoV-2 antigen/reverse transcription polymerase chain reaction [RT-PCR]) cases and test-negative case-controls (via RT-PCR) based on admission date, preceding vaccinations, and age. We evaluated the rVEs of four monovalent COVID-19 vaccines (AZD1222, Ad26.COV2.S, CoronaVac, and BNT162b2) as second boosters compared with any first boosters received \u22654 months previously, and as first boosters compared with primary-series vaccinations completed \u22654 months previously.\r\n\r\nThe overall rVE of second boosters, from 5668 (2238 test-positive) evaluated hospitalizations, was 24.7 % (95 % confidence interval [CI]: 12.6-35.1); the overall rVE of first boosters, from 30,272 (12,063 test-positive) hospitalizations, was 46.8 % (95 % CI: 43.3-50.0). The rVEs of AZD1222 and BNT162b2 were similar: 29.4 % (95 % CI: 8.6-45.5) and 25.5 % (95 % CI: 4.2-42.2), respectively, for second boosters; and 42.5 % (95 % CI: 28.0-54.0) and 50.8 % (95 % CI: 47.5-54.0), respectively, for first boosters. In general, rVEs were higher in elderly (\u226580 years) and immunocompromised/high-risk individuals.\r\n\r\nOur results support the use of AZD1222 and other adenoviral/mRNA vaccine boosters to maintain protection against COVID-19 hospitalization from Omicron subvariants, including in elderly and immunocompromised individuals at increased risk of accelerated waning or severe outcomes.", "doi": "10.1016/j.vaccine.2023.08.085", "pmid": "37704499", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(23)01051-4"}], "notes": [], "created": "2023-10-06T06:52:27.599Z", "modified": "2023-10-06T09:13:58.218Z"}, {"entity": "publication", "iuid": "cb04059790e140e3aacb27d3654f89c2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cb04059790e140e3aacb27d3654f89c2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cb04059790e140e3aacb27d3654f89c2"}}, "title": "Seizures in hospitalised paediatric patients with SARS-CoV-2 and comparison of severity with seizures in hospitalised paediatric patients with other respiratory viruses during the COVID-19 pandemic: a population-based cohort study.", "authors": [{"family": "Anastasopoulou", "given": "Stavroula", "initials": "S", "orcid": "0000-0002-4210-0064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/649861ba67894cba90ec4340f5bc07a3.json"}}, {"family": "Svensson", "given": "Eva", "initials": "E"}, {"family": "Wickstr\u00f6m", "given": "Ronny", "initials": "R"}, {"family": "Hertting", "given": "Olof", "initials": "O"}, {"family": "Rinder", "given": "Malin Ryd", "initials": "MR"}, {"family": "Bennet", "given": "Rutger", "initials": "R"}, {"family": "Eriksson", "given": "Margareta", "initials": "M"}], "type": "journal article", "published": "2023-10-05", "journal": {"title": "Arch Dis Child", "issn": "1468-2044", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To study seizures in patients hospitalised due to SARS-CoV-2 infection, and compare their severity with seizures in patients hospitalised due to other viral respiratory tract infections (RTIs).\r\n\r\nObservational population-based cohort study.\r\n\r\nNorthern Stockholm.\r\n\r\nPatients aged 1 month-18 years hospitalised due to SARS-CoV-2 with and without seizures, and patients of the same age hospitalised due to other viral RTIs with seizures, between 1 March 2020 and 30 June 2022.\r\n\r\nThe prevalence of seizures in hospitalised patients due to SARS-CoV-2, the evaluation of assumed predictors of seizures and the comparison of severity markers in patients with SARS-CoV-2 versus other RTIs.\r\n\r\n32 of 239 included patients (13.4%) admitted due to SARS-CoV-2 infection had seizures. Central nervous system (CNS) disease and the omicron period had significantly increased OR for seizures (OR: 5.12; CI: 2.06 to 12.72 and OR: 3.01; CI: 1.15 to 7.88, respectively). Seizures in patients with SARS-CoV-2 were more common in children older than 5 years (p=0.001), even in the absence of fever (p=0.007), as compared with other viral RTIs. The duration of hospitalisation was longer in patients with seizures due to other viral RTIs (p=0.023). There was no significant difference regarding severity markers of seizures between the two groups.\r\n\r\nCNS disease and the omicron period were risk factors for seizures in patients with SARS-CoV-2, who were older than patients with other RTIs. The severity of seizures was comparable between the two groups; hospitalisation was however longer in patients with other RTIs.", "doi": "10.1136/archdischild-2023-325974", "pmid": "37798081", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "archdischild-2023-325974"}], "notes": [], "created": "2023-11-01T13:32:30.834Z", "modified": "2023-11-02T07:08:08.817Z"}, {"entity": "publication", "iuid": "9c74268f95a24e3ebf847acd863c1c28", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9c74268f95a24e3ebf847acd863c1c28.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9c74268f95a24e3ebf847acd863c1c28"}}, "title": "Extracellular vesicles in plasma and cerebrospinal fluid in patients with COVID-19 and neurological symptoms.", "authors": [{"family": "Taxiarchis", "given": "Apostolos", "initials": "A", "orcid": "0000-0003-2137-715X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c141f0b728747da86c5a682a77eeed3.json"}}, {"family": "Bellander", "given": "Bo-Michael", "initials": "B"}, {"family": "Antovic", "given": "Jovan", "initials": "J"}, {"family": "Soutari", "given": "Nida", "initials": "N"}, {"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Karakoyun", "given": "Can", "initials": "C"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Antovic", "given": "Aleksandra", "initials": "A"}], "type": "journal article", "published": "2023-10-05", "journal": {"title": "Int J Lab Hematol", "issn": "1751-553X", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Increased levels of extracellular vesicles (EVs) are associated with haemostatic disturbances in various clinical settings. However, their role in COVID-19 patients is still not fully clear. In the present study we investigated EVs in plasma from patients with COVID-19 and neurological symptoms in relation to the activation of coagulation.\r\n\r\nNineteen COVID-19 patients with neurological symptoms and twenty-three aged-matched healthy individuals were included. Global coagulation assays were performed and levels of EVs were determined by flow-cytometry in plasma and cerebrospinal fluid (CSF).\r\n\r\nA procoagulant state characterized by significantly increased overall coagulation- (OCP) and overall haemostatic potential (OHP), diminished overall fibrinolytic potential (OFP) together with a denser fibrin structure was found in patients with COVID-19. Flow cytometry revealed elevated levels of plasma circulating EVs derived from neutrophils (MPO+) and platelets (CD61+), as well as EVs expressing phosphatidylserine (PS+) and complement component C5b-9 (TCC+) in patients with COVID-19 compared with controls. The concentrations of PS+, CD61+ and TCC+ EVs were positively correlated with OCP and OHP in COVID-19 patients. Moreover, we identified CD61+, MPO+ and endothelial cell-derived EVs, as well as EVs exposing PS and TCC in the CSF of patients suffering from neurological symptoms during COVID-19.\r\n\r\nThe unique finding in this study was the presence of EVs in the CSF of COVID-19 patients with neurologic manifestations as well as higher expression of complement protein on circulating plasma EVs. EVs may indicate blood-brain barrier damage during SARS-COV-2 infection.", "doi": "10.1111/ijlh.14182", "pmid": "37795549", "labels": {"Funder: KAW/SciLifeLab": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:31:35.468Z", "modified": "2023-11-01T13:42:24.975Z"}, {"entity": "publication", "iuid": "0e323a2c2ff247e589894e18a5dda5f6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e323a2c2ff247e589894e18a5dda5f6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e323a2c2ff247e589894e18a5dda5f6"}}, "title": "Habitual short sleepers with pre-existing medical conditions are at higher risk of Long COVID.", "authors": [{"family": "Berezin", "given": "Linor", "initials": "L"}, {"family": "Waseem", "given": "Rida", "initials": "R"}, {"family": "Merikanto", "given": "Ilona", "initials": "I"}, {"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L"}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Korman", "given": "Maria", "initials": "M"}, {"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "Espie", "given": "Colin", "initials": "C"}, {"family": "Landtblom", "given": "Anne-Marie", "initials": "A"}, {"family": "Penzel", "given": "Thomas", "initials": "T"}, {"family": "Matsui", "given": "Kentaro", "initials": "K"}, {"family": "Hrubos-Str\u00f8m", "given": "Harald", "initials": "H"}, {"family": "Mota-Rolim", "given": "S\u00e9rgio", "initials": "S"}, {"family": "Nadorff", "given": "Michael R", "initials": "MR"}, {"family": "Plazzi", "given": "Giuseppe", "initials": "G"}, {"family": "Reis", "given": "Catia", "initials": "C"}, {"family": "Chan", "given": "Rachel Ngan Yin", "initials": "RNY"}, {"family": "Cunha", "given": "Ana Suely", "initials": "AS"}, {"family": "Yordanova", "given": "Juliana", "initials": "J"}, {"family": "Bjelajac", "given": "Adrijana Koscec", "initials": "AK"}, {"family": "Inoue", "given": "Yuichi", "initials": "Y"}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "Chung", "given": "Frances", "initials": "F"}], "type": "journal article", "published": "2023-10-03", "journal": {"title": "J Clin Sleep Med", "issn": "1550-9397", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Preliminary evidence suggests that the risk of Long COVID is higher among people with pre-existing medical conditions. Based on its proven adjuvant role in immunity, habitual sleep duration may alter the risk for developing Long COVID. The objective of this study was to determine whether the odds of Long COVID are higher amongst those with pre-existing medical conditions, and whether the strength of this association varies by habitual sleep duration.\r\n\r\nUsing data from 13,461 respondents from 16 countries who participated in the 2021 survey based International COVID Sleep Study II (ICOSS II), we studied the associations between habitual sleep duration, pre-existing medical conditions, and Long COVID.\r\n\r\nOf 2,508 individuals who had COVID-19, 61% reported at least one Long COVID symptom. Multivariable logistic regression analysis showed that the risk of having Long COVID was 1.8-fold higher for average-length sleepers (6-9h/night) with pre-existing medical conditions compared to those without pre-existing medical conditions [aOR 1.84 (1.18-2.90), P=0.008]. The risk of Long COVID was 3-fold higher for short sleepers with pre-existing medical conditions [aOR 2.95 (1.04-8.4), P=0.043] and not significantly higher for long sleepers with pre-existing conditions [aOR 2.11 (0.93-4.77), P=0.073] compared to average-length sleepers without pre-existing conditions.\r\n\r\nHabitual short nighttime sleep duration exacerbated the risk of Long COVID in individuals with pre-existing conditions. Restoring nighttime sleep to average duration represents a potentially modifiable behavioral factor to lower the odds of Long COVID for at-risk patients.", "doi": "10.5664/jcsm.10818", "pmid": "37858285", "labels": {"Category: Health": null, "Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:34:19.743Z", "modified": "2023-11-02T07:48:57.999Z"}, {"entity": "publication", "iuid": "8d078daade6a478fabf0a33c296442e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d078daade6a478fabf0a33c296442e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d078daade6a478fabf0a33c296442e7"}}, "title": "A retrospective multicenter cohort study of the association between anti-Factor Xa values and death, thromboembolism, and bleeding in patients with critical COVID-19.", "authors": [{"family": "Jonmarker", "given": "Sandra", "initials": "S", "orcid": "0000-0001-5836-8594", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d28ab27b84f40e2b3d57c91595ece92.json"}}, {"family": "Litorell", "given": "Jacob", "initials": "J"}, {"family": "Alarcon", "given": "Felix", "initials": "F"}, {"family": "Al-Abani", "given": "Kais", "initials": "K", "orcid": "0000-0002-1789-1538", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a63c8ea9d2b4263817a82795ff41e55.json"}}, {"family": "Bj\u00f6rkman", "given": "Sofia", "initials": "S"}, {"family": "Farm", "given": "Maria", "initials": "M", "orcid": "0000-0003-3696-463X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6de1008608a5480e83cad2a4b1148967.json"}}, {"family": "Grip", "given": "Jonathan", "initials": "J", "orcid": "0000-0001-9735-4160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c335d9cd48e4dd4b193b77e61850257.json"}}, {"family": "S\u00f6derberg", "given": "M\u00e5rten", "initials": "M", "orcid": "0000-0002-1043-3630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/947a6a5a9cf840a0ad95685ed3cbff84.json"}}, {"family": "Hollenberg", "given": "Jacob", "initials": "J", "orcid": "0000-0002-3100-9716", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa5fcdb83dfb4b2db965edaa7cdec033.json"}}, {"family": "Wahlin", "given": "Rebecka Rubenson", "initials": "RR", "orcid": "0000-0003-3890-8236", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac398b363ac24711ba64957e9b5d1940.json"}}, {"family": "Kander", "given": "Thomas", "initials": "T", "orcid": "0000-0002-5404-2981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a22b3691ec6c4b8ebe4b4a15ca9e4b02.json"}}, {"family": "Rimling", "given": "Liivi", "initials": "L"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J", "orcid": "0000-0001-8739-7896", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c2fb174ab842c8809900877de8c008.json"}}, {"family": "Joelsson-Alm", "given": "Eva", "initials": "E", "orcid": "0000-0002-9041-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07a091265e654b21bc27fa14b93e4ec0.json"}}, {"family": "Dahlberg", "given": "Martin", "initials": "M", "orcid": "0000-0002-1271-8736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27361cedab254730be4df04b4df64a77.json"}}, {"family": "Cronhjort", "given": "Maria", "initials": "M", "orcid": "0000-0002-0444-8553", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/198af039066341ac8538d5e9b9ea9e32.json"}}], "type": "journal article", "published": "2023-10-02", "journal": {"title": "Thromb J", "issn": "1477-9560", "issn-l": null, "volume": "21", "issue": "1", "pages": "101"}, "abstract": "Patients with critical COVID-19 have a high risk of thromboembolism, but intensified thromboprophylaxis has not been proven beneficial. The activity of low-molecular-weight heparins can be monitored by measuring anti-Factor Xa. We aimed to study the association between anti-Factor Xa values and death, thromboembolism, and bleeding in patients with critical COVID-19.\r\n\r\nThis retrospective cohort study included adult patients with critical COVID-19 admitted to an intensive care unit at three Swedish hospitals between March 2020 and May 2021 with at least one valid peak and/or trough anti-Factor Xa value. Within the peak and trough categories, patients' minimum, median, and maximum values were determined. Logistic regressions with splines were used to assess associations.\r\n\r\nIn total, 408 patients had at least one valid peak and/or trough anti-Factor Xa measurement, resulting in 153 patients with peak values and 300 patients with trough values. Lower peak values were associated with thromboembolism for patients' minimum (p = 0.01), median (p = 0.005) and maximum (p = 0.001) values. No association was seen between peak values and death or bleeding. Higher trough values were associated with death for median (p = 0.03) and maximum (p = 0.002) values and with both bleeding (p = 0.01) and major bleeding (p = 0.02) for maximum values, but there were no associations with thromboembolism.\r\n\r\nMeasuring anti-Factor Xa activity may be relevant for administrating low-molecular-weight heparin to patients with critical COVID-19. Lower peak values were associated with an increased risk of thromboembolism, and higher trough values were associated with an increased risk of death and bleeding. Prospective studies are needed to confirm the results.\r\n\r\nThe study was retrospectively registered at Clinicaltrials.gov, NCT05256524, February 24, 2022.", "doi": "10.1186/s12959-023-00541-z", "pmid": "37784131", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10544466"}, {"db": "pii", "key": "10.1186/s12959-023-00541-z"}, {"db": "ClinicalTrials.gov", "key": "NCT05256524"}], "notes": [], "created": "2023-11-01T13:32:16.871Z", "modified": "2023-11-01T13:57:22.624Z"}, {"entity": "publication", "iuid": "2b4e178db7a44c5688dcaff545589bae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b4e178db7a44c5688dcaff545589bae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b4e178db7a44c5688dcaff545589bae"}}, "title": "Clinical standards for diagnosis, treatment and prevention of post-COVID-19 lung disease.", "authors": [{"family": "Visca", "given": "D", "initials": "D"}, {"family": "Centis", "given": "R", "initials": "R"}, {"family": "Pontali", "given": "E", "initials": "E"}, {"family": "Zampogna", "given": "E", "initials": "E"}, {"family": "Russell", "given": "A-M", "initials": "A"}, {"family": "Migliori", "given": "G B", "initials": "GB"}, {"family": "Andrejak", "given": "C", "initials": "C"}, {"family": "Aro", "given": "M", "initials": "M"}, {"family": "Bayram", "given": "H", "initials": "H"}, {"family": "Berkani", "given": "K", "initials": "K"}, {"family": "Bruchfeld", "given": "J", "initials": "J"}, {"family": "Chakaya", "given": "J M", "initials": "JM"}, {"family": "Chorostowska-Wynimko", "given": "J", "initials": "J"}, {"family": "Crestani", "given": "B", "initials": "B"}, {"family": "Dalcolmo", "given": "M P", "initials": "MP"}, {"family": "D'Ambrosio", "given": "L", "initials": "L"}, {"family": "Dinh-Xuan", "given": "A-T", "initials": "A"}, {"family": "Duong-Quy", "given": "S", "initials": "S"}, {"family": "Fernandes", "given": "C", "initials": "C"}, {"family": "Garc\u00eda-Garc\u00eda", "given": "J-M", "initials": "J"}, {"family": "de Melo Kawassaki", "given": "A", "initials": "A"}, {"family": "Carrozzi", "given": "L", "initials": "L"}, {"family": "Martinez-Garcia", "given": "M A", "initials": "MA"}, {"family": "Martins", "given": "P Carreiro", "initials": "PC"}, {"family": "Mirsaeidi", "given": "M", "initials": "M"}, {"family": "Mohammad", "given": "Y", "initials": "Y"}, {"family": "Naidoo", "given": "R N", "initials": "RN"}, {"family": "Neuparth", "given": "N", "initials": "N"}, {"family": "Sese", "given": "L", "initials": "L"}, {"family": "Silva", "given": "D R", "initials": "DR"}, {"family": "Solovic", "given": "I", "initials": "I"}, {"family": "Sooronbaev", "given": "T M", "initials": "TM"}, {"family": "Spanevello", "given": "A", "initials": "A"}, {"family": "Sverzellati", "given": "N", "initials": "N"}, {"family": "Tanno", "given": "L", "initials": "L"}, {"family": "Tiberi", "given": "S", "initials": "S"}, {"family": "Vasankari", "given": "T", "initials": "T"}, {"family": "Vasarmidi", "given": "E", "initials": "E"}, {"family": "Vitacca", "given": "M", "initials": "M"}, {"family": "Annesi-Maesano", "given": "I", "initials": "I"}], "type": "journal article", "published": "2023-10-01", "journal": {"title": "Int J Tuberc Lung Dis", "issn": "1815-7920", "issn-l": null, "volume": "27", "issue": "10", "pages": "729-741"}, "abstract": "BACKGROUND: The aim of these clinical standards is to provide guidance on 'best practice' care for the diagnosis, treatment and prevention of post-COVID-19 lung disease.METHODS: A panel of international experts representing scientific societies, associations and groups active in post-COVID-19 lung disease was identified; 45 completed a Delphi process. A 5-point Likert scale indicated level of agreement with the draft standards. The final version was approved by consensus (with 100% agreement).RESULTS: Four clinical standards were agreed for patients with a previous history of COVID-19: Standard 1, Patients with sequelae not explained by an alternative diagnosis should be evaluated for possible post-COVID-19 lung disease; Standard 2, Patients with lung function impairment, reduced exercise tolerance, reduced quality of life (QoL) or other relevant signs or ongoing symptoms \u22654 weeks after the onset of first symptoms should be evaluated for treatment and pulmonary rehabilitation (PR); Standard 3, The PR programme should be based on feasibility, effectiveness and cost-effectiveness criteria, organised according to local health services and tailored to an individual patient's needs; and Standard 4, Each patient undergoing and completing PR should be evaluated to determine its effectiveness and have access to a counselling/health education session.CONCLUSION: This is the first consensus-based set of clinical standards for the diagnosis, treatment and prevention of post-COVID-19 lung disease. Our aim is to improve patient care and QoL by guiding clinicians, programme managers and public health officers in planning and implementing a PR programme to manage post-COVID-19 lung disease.", "doi": "10.5588/ijtld.23.0248", "pmid": "37749839", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC10519381"}], "notes": [], "created": "2023-10-06T06:56:22.374Z", "modified": "2023-10-06T11:17:11.963Z"}, {"entity": "publication", "iuid": "8ff5d63b7d214c3ca0b2c2fa34c71790", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ff5d63b7d214c3ca0b2c2fa34c71790.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ff5d63b7d214c3ca0b2c2fa34c71790"}}, "title": "Anxiety and depression played a central role in the COVID-19 mental distress: A network analysis.", "authors": [{"family": "Fico", "given": "Giovanna", "initials": "G"}, {"family": "Oliva", "given": "Vincenzo", "initials": "V"}, {"family": "De Prisco", "given": "Michele", "initials": "M"}, {"family": "Fortea", "given": "Lydia", "initials": "L"}, {"family": "Fortea", "given": "Adriana", "initials": "A"}, {"family": "Gim\u00e9nez-Palomo", "given": "Anna", "initials": "A"}, {"family": "Anmella", "given": "Gerard", "initials": "G"}, {"family": "Hidalgo-Mazzei", "given": "Diego", "initials": "D"}, {"family": "Vazquez", "given": "Mireia", "initials": "M"}, {"family": "Gomez-Ramiro", "given": "Marta", "initials": "M"}, {"family": "Carreras", "given": "Bernat", "initials": "B"}, {"family": "Murru", "given": "Andrea", "initials": "A"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Mortier", "given": "Philippe", "initials": "P"}, {"family": "Vilagut", "given": "Gemma", "initials": "G"}, {"family": "Amigo", "given": "Franco", "initials": "F"}, {"family": "Ferrer", "given": "Montse", "initials": "M"}, {"family": "Garc\u00eda-Mieres", "given": "Helena", "initials": "H"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Alonso", "given": "Jordi", "initials": "J"}], "type": "journal article", "published": "2023-10-01", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "issn-l": null, "volume": "338", "issue": null, "pages": "384-392"}, "abstract": "Psychological, socio-demographics, and clinical factors play an important role in patients with COVID-19, but their relationship is complex. The network approach might be used to disentangle complex interactions in different systems. Using data from a multicentre, cross-sectional, survey among patients with COVID-19 in Spain (July-November 2020), we investigated the network structure of mental disorders symptoms, social support, and psychological resilience, and changes in network structures according to the presence of a pre-existing mental disorder or hospitalization for COVID-19.\r\n\r\nSubjects completed a survey to evaluate sociodemographic characteristics, COVID-19 infection status, resilience, social support, and symptoms of depression, anxiety disorders, post-traumatic stress disorder, panic attacks, and substance use disorder. 2084 patients with COVID-19 were included in the analysis. Network analysis was conducted to evaluate network and bridge centrality, and the network properties were compared between COVID-19 patients with and without a history of lifetime mental disorder, and between hospitalized and non-hospitalized patients.\r\n\r\nGeneralization of our findings may be difficult since differences in network connectivity may exist in different populations or samples.\r\n\r\nAnxiety and depression showed high centrality in patients with COVID-19 and anxiety showed the highest bridge influence in the network. Resilience and social support showed a low influence on mental disorder symptoms. Global network estimations show no statistically significant changes between patients with and without pre-existing mental disorders or between hospitalized and non-hospitalized patients.\r\n\r\nAnxiety might be a key treatment target in patients with COVID-19 since its treatment might prevent other mental health adverse outcomes.", "doi": "10.1016/j.jad.2023.06.034", "pmid": "37336249", "labels": {"Category: Social Science & Humanities": null, "Funder: H2020": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10276655"}, {"db": "pii", "key": "S0165-0327(23)00799-1"}], "notes": [], "created": "2023-10-04T09:31:19.003Z", "modified": "2023-10-04T10:48:42.360Z"}, {"entity": "publication", "iuid": "a9399f5eff8949499e9364604ce29b07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a9399f5eff8949499e9364604ce29b07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a9399f5eff8949499e9364604ce29b07"}}, "title": "The use and access to contraception in Sweden during the COVID-19 pandemic period.", "authors": [{"family": "Envall", "given": "Niklas", "initials": "N", "orcid": "0000-0003-2813-7642", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/374e845be5ee48c89221e0d6d3fd6af6.json"}}, {"family": "Gemzell Danielsson", "given": "Kristina", "initials": "K", "orcid": "0000-0001-6516-1444", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be16fea6bd1042048b8a4008dc005014.json"}}, {"family": "Kopp Kallner", "given": "Helena", "initials": "H", "orcid": "0000-0001-7184-9165", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd943a169d9c47d69749d5831f65a191.json"}}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Eur J Contracept Reprod Health Care", "issn": "1473-0782", "issn-l": null, "volume": "28", "issue": "5", "pages": "275-281"}, "abstract": "Explore perceived access to, the need for, use of, and satisfaction with telemedicine services for contraceptive counselling and prescription-renewal-only during the COVID-19 pandemic, and the impact of the COVID-19 pandemic period on the choice and use of contraceptives.\r\n\r\nInternet-based e-survey of Swedish women of fertile age, 16-49 years.\r\n\r\nIn total, 1016 participants completed the survey. Most participants (69.7%) rated their access to contraceptive services 'as usual'. Among the remaining participants, a higher proportion rated their access as deteriorated (73.4%) compared to improved (26.6%; p < 0.001). In total, 38.0% reported a need for contraceptive counselling, whereof 14.0% had used telemedicine for counselling and reported high satisfaction. Telemedicine for prescription-renewal-only was used by 15.1% of the total population. Two per cent reported use of another contraceptive than their intended, whereof long-acting reversible contraceptives were the most common intended method. The proportion of current contraceptive users was lower than in 2017 (62.4% vs 71.1%, p < 0.001), and current users of long-acting reversible contraception decreased from 30.6% to 19.3% (p < 0.001).\r\n\r\nDuring the COVID-19 pandemic period, most women found their access to contraceptive services unaffected, but more women felt that it had deteriorated than improved. The use of telemedicine was low, and the use of contraception overall fell. Efforts are needed to raise awareness of available services, and TM-provided interventions for maintained quality of care and informed decision-making remain to be evaluated.SHORT CONDENSATIONThe COVID-19 period imposed a change in contraceptive service provision, and efforts are needed to raise awareness of available services, including telemedicine. Access to all contraceptives, including LARCs, is crucial and telemedicine-provided interventions need evaluation.", "doi": "10.1080/13625187.2023.2260516", "pmid": "37902288", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:32:14.142Z", "modified": "2023-11-01T13:56:01.692Z"}, {"entity": "publication", "iuid": "2eab3dd11de845c988ce6eac5a9f9d76", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2eab3dd11de845c988ce6eac5a9f9d76.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2eab3dd11de845c988ce6eac5a9f9d76"}}, "title": "The four domains of the person-centred practice framework from the perspective of critical care nurses in intensive care units during a pandemic.", "authors": [{"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Nordin", "given": "Anna", "initials": "A"}, {"family": "Fredholm", "given": "Angelica", "initials": "A"}, {"family": "Engstr\u00f6m", "given": "\u00c5sa", "initials": "\u00c5"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "issn-l": null, "volume": "78", "issue": null, "pages": "103449"}, "abstract": "The aim was to describe the Person-Centred Practice Framework's four domains (prerequisites, care environment, person-centred processes, and person-centred outcomes) through the perspectives of critical care nurses working in intensive care units during the second year of the COVID-19 pandemic. Furthermore, the aim was to investigate the relationships between prerequisites, care environment, person-centred processes, and person-centred outcomes.\r\n\r\nA cross-sectional study involving questionnaires. Prerequisites were measured using person-related conditions, the care environment by using the Person-Centred Climate Questionnaire-Staff version, the person-centred processes by using the Person-Centred Care Assessment Tool and person-centred outcomes were measured with one question about present health and well-being and by using Self-rated Exhaustion Disorder. Descriptive and analytic statistics were used. Data was collected from July 2021 to November 2021.\r\n\r\nCritical care nurses (n = 217) working in 15 Swedish adult intensive care units.\r\n\r\nParticipants' average length of experience in intensive care units was 14 years, and most participants experienced increased nursing care responsibilities. They perceived the climate as safe but had limitations in terms of its everydayness and community. Participants perceived the organisations both supported and hindered personalized care. Most participants experienced a variety of exhaustion symptoms, and their health had positive relationship with community.\r\n\r\nBy showing how prerequisites, care environment, person-centred process influences critical care nurses' health and well-being, organisations might identify aspects in the work environment that require targeted interventions to reach healthy workplaces.\r\n\r\nTo preserve the health and well-being of critical care nurses and to flourish as humans in their professional roles, they need to interact with and form relationships with their colleagues, patients, and relatives. Organisations should have a person-centred approach for every individual in the workforce to harness each critical care nurses' knowledge and skills for individuals to growth in their roles.", "doi": "10.1016/j.iccn.2023.103449", "pmid": "37169630", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(23)00066-6"}], "notes": [], "created": "2023-10-04T05:12:14.095Z", "modified": "2023-10-04T08:13:38.344Z"}, {"entity": "publication", "iuid": "28090ad69226499a866997ce4999b25f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/28090ad69226499a866997ce4999b25f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/28090ad69226499a866997ce4999b25f"}}, "title": "Social determinants of health and vaccine uptake during the first wave of the COVID-19 pandemic: A systematic review.", "authors": [{"family": "Vardavas", "given": "Constantine", "initials": "C"}, {"family": "Nikitara", "given": "Katerina", "initials": "K"}, {"family": "Aslanoglou", "given": "Katerina", "initials": "K"}, {"family": "Lagou", "given": "Ioanna", "initials": "I"}, {"family": "Marou", "given": "Valia", "initials": "V"}, {"family": "Phalkey", "given": "Revati", "initials": "R"}, {"family": "Leonardi-Bee", "given": "Jo", "initials": "J"}, {"family": "Fernandez", "given": "Esteve", "initials": "E"}, {"family": "Vivilaki", "given": "Victoria", "initials": "V"}, {"family": "Kamekis", "given": "Apostolos", "initials": "A"}, {"family": "Symvoulakis", "given": "Emmanouil", "initials": "E"}, {"family": "Noori", "given": "Teymur", "initials": "T"}, {"family": "Wuerz", "given": "Andrea", "initials": "A"}, {"family": "Suk", "given": "Jonathan E", "initials": "JE"}, {"family": "Deogan", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Prev Med Rep", "issn": "2211-3355", "issn-l": null, "volume": "35", "issue": null, "pages": "102319"}, "abstract": "Social determinants of health significantly impact population health status. The aim of this systematic review was to examine which social vulnerability factors or determinants of health at the individual or county level affected vaccine uptake within the first phase of the vaccination program. We performed a systematic review of peer-reviewed literature published from January 2020 until September 2021 in Medline and Embase (Bagaria et al., 2022) and complemented the review with an assessment of pre-print literature within the same period. We restricted our criteria to studies performed in the EU/UK/EEA/US that report vaccine uptake in the general population as the primary outcome and included various social determinants of health as explanatory variables. This review provides evidence of significant associations between the early phases of vaccination uptake for SARS-CoV-2 and multiple socioeconomic factors including income, poverty, deprivation, race/ethnicity, education and health insurance. The identified associations should be taken into account to increase vaccine uptake in socially vulnerable groups, and to reduce disparities in uptake, in particular within the context of public health preparedness for future pandemics. While further corroboration is needed to explore the generalizability of these findings across the European setting, these results confirm the need to consider vulnerable groups and social determinants of health in the planning and roll-out of SARS-CoV-2 vaccination programs and within the context of future respiratory pandemics.", "doi": "10.1016/j.pmedr.2023.102319", "pmid": "37564118", "labels": {"Category: Public Health": null, "Type: Other": null, "Category: Vaccines": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10410576"}, {"db": "pii", "key": "S2211-3355(23)00210-3"}], "notes": [], "created": "2023-10-05T08:26:56.988Z", "modified": "2023-10-06T05:18:43.511Z"}, {"entity": "publication", "iuid": "f9262871622b4418a92b7fe26ba35003", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f9262871622b4418a92b7fe26ba35003.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f9262871622b4418a92b7fe26ba35003"}}, "title": "Similarities and differences between myocarditis following COVID-19 mRNA vaccine and multiple inflammatory syndrome with cardiac involvement in children.", "authors": [{"family": "Amodio", "given": "Donato", "initials": "D"}, {"family": "Pascucci", "given": "Giuseppe Rubens", "initials": "GR"}, {"family": "Cotugno", "given": "Nicola", "initials": "N"}, {"family": "Rossetti", "given": "Chiara", "initials": "C"}, {"family": "Manno", "given": "Emma Concetta", "initials": "EC"}, {"family": "Pighi", "given": "Chiara", "initials": "C"}, {"family": "Morrocchi", "given": "Elena", "initials": "E"}, {"family": "D'Alessandro", "given": "Annamaria", "initials": "A"}, {"family": "Perrone", "given": "Marco Alfonso", "initials": "MA"}, {"family": "Valentini", "given": "Alessandra", "initials": "A"}, {"family": "Franceschini", "given": "Alessio", "initials": "A"}, {"family": "Chinali", "given": "Marcello", "initials": "M"}, {"family": "Deodati", "given": "Annalisa", "initials": "A"}, {"family": "Azzari", "given": "Chiara", "initials": "C"}, {"family": "Rossi", "given": "Paolo", "initials": "P"}, {"family": "Cianfarani", "given": "Stefano", "initials": "S"}, {"family": "Andreani", "given": "Marco", "initials": "M"}, {"family": "Porzio", "given": "Ottavia", "initials": "O"}, {"family": "Palma", "given": "Paolo", "initials": "P"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Clin Immunol", "issn": "1521-7035", "issn-l": "1521-6616", "volume": "255", "issue": null, "pages": "109751"}, "abstract": "Despite the multiple benefits of vaccination, cardiac adverse Events Following COVID-19 Immunization (c-AEFI) have been reported. These events as well as the severe cardiac involvement reported in Multisystem inflammatory syndrome in children (MIS-C) appear more frequent in young adult males. Herein, we firstly report on the inflammatory profiles of patients experiencing c-AEFI in comparison with age, pubertal age and gender matched MIS-C with cardiac involvement. Proteins related to systemic inflammation were found higher in MIS-C compared to c-AEFI, whereas a higher level in proteins related to myocardial injury was found in c-AEFI. In addition, higher levels of DHEAS, DHEA, and cortisone were found in c-AEFI which persisted at follow-up. No anti-heart muscle and anti-endothelial cell antibodies have been detected. Overall current comparative data showed a distinct inflammatory and androgens profile in c-AEFI patients which results to be well restricted on heart and to persist months after the acute event.", "doi": "10.1016/j.clim.2023.109751", "pmid": "37660743", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S1521-6616(23)00514-4"}], "notes": [], "created": "2023-10-06T06:57:25.920Z", "modified": "2023-10-06T11:44:34.935Z"}, {"entity": "publication", "iuid": "ef42a285208240baa62ce1067842698e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef42a285208240baa62ce1067842698e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef42a285208240baa62ce1067842698e"}}, "title": "SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC).", "authors": [{"family": "Proal", "given": "Amy D", "initials": "AD", "orcid": "0009-0001-9495-8572", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/71ae496981a84b65afae37e357cf914e.json"}}, {"family": "VanElzakker", "given": "Michael B", "initials": "MB"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Bach", "given": "Katie", "initials": "K"}, {"family": "Boribong", "given": "Brittany P", "initials": "BP", "orcid": "0000-0003-1297-6337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb77f79511294f40aca32d51eaf41722.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}, {"family": "Cherry", "given": "Sara", "initials": "S", "orcid": "0000-0003-3956-6610", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ad4bd94f6194d34b799713f6dd29894.json"}}, {"family": "Chertow", "given": "Daniel S", "initials": "DS", "orcid": "0000-0002-1675-1728", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73aa9c5fa5cc484ebb2015a232494c10.json"}}, {"family": "Davies", "given": "Helen E", "initials": "HE", "orcid": "0000-0001-6102-256X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f50576440954cbe858c48cedc8b5965.json"}}, {"family": "Dupont", "given": "Christopher L", "initials": "CL", "orcid": "0000-0002-0896-6542", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7046b17752c5423a9440ad095e12b07a.json"}}, {"family": "Deeks", "given": "Steven G", "initials": "SG"}, {"family": "Eimer", "given": "William", "initials": "W"}, {"family": "Ely", "given": "E Wesley", "initials": "EW"}, {"family": "Fasano", "given": "Alessio", "initials": "A"}, {"family": "Freire", "given": "Marcelo", "initials": "M", "orcid": "0000-0003-4906-7698", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/716676d7968943dab31508c7bd750590.json"}}, {"family": "Geng", "given": "Linda N", "initials": "LN"}, {"family": "Griffin", "given": "Diane E", "initials": "DE"}, {"family": "Henrich", "given": "Timothy J", "initials": "TJ"}, {"family": "Iwasaki", "given": "Akiko", "initials": "A", "orcid": "0000-0002-7824-9856", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1322301ffd9b4e9bb73ade8fd48d3fd3.json"}}, {"family": "Izquierdo-Garcia", "given": "David", "initials": "D"}, {"family": "Locci", "given": "Michela", "initials": "M"}, {"family": "Mehandru", "given": "Saurabh", "initials": "S", "orcid": "0000-0001-9781-2969", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b81ff206ff0442438dc34abdb197326a.json"}}, {"family": "Painter", "given": "Mark M", "initials": "MM", "orcid": "0000-0002-0180-2748", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ec1e890408445f78038bde6f415ae9a.json"}}, {"family": "Peluso", "given": "Michael J", "initials": "MJ"}, {"family": "Pretorius", "given": "Etheresia", "initials": "E"}, {"family": "Price", "given": "David A", "initials": "DA", "orcid": "0000-0001-9416-2737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/734b7fd55fca47f8b00d1281331ef39a.json"}}, {"family": "Putrino", "given": "David", "initials": "D"}, {"family": "Scheuermann", "given": "Richard H", "initials": "RH", "orcid": "0000-0003-1355-892X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e5d8fb69cab46d1a8465f6a9b170d4c.json"}}, {"family": "Tan", "given": "Gene S", "initials": "GS"}, {"family": "Tanzi", "given": "Rudolph E", "initials": "RE", "orcid": "0000-0002-7032-1454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d99336757334246aae0b6ddd36255c2.json"}}, {"family": "VanBrocklin", "given": "Henry F", "initials": "HF"}, {"family": "Yonker", "given": "Lael M", "initials": "LM", "orcid": "0000-0003-1711-8227", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75531a54672a44e7bf7f16d97def6b33.json"}}, {"family": "Wherry", "given": "E John", "initials": "EJ", "orcid": "0000-0003-0477-1956", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8eb744c9e4544fc0b0a7569b48349044.json"}}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Nat Immunol", "issn": "1529-2916", "issn-l": null, "volume": "24", "issue": "10", "pages": "1616-1627"}, "abstract": "Millions of people are suffering from Long COVID or post-acute sequelae of COVID-19 (PASC). Several biological factors have emerged as potential drivers of PASC pathology. Some individuals with PASC may not fully clear the coronavirus SARS-CoV-2 after acute infection. Instead, replicating virus and/or viral RNA-potentially capable of being translated to produce viral proteins-persist in tissue as a 'reservoir'. This reservoir could modulate host immune responses or release viral proteins into the circulation. Here we review studies that have identified SARS-CoV-2 RNA/protein or immune responses indicative of a SARS-CoV-2 reservoir in PASC samples. Mechanisms by which a SARS-CoV-2 reservoir may contribute to PASC pathology, including coagulation, microbiome and neuroimmune abnormalities, are delineated. We identify research priorities to guide the further study of a SARS-CoV-2 reservoir in PASC, with the goal that clinical trials of antivirals or other therapeutics with potential to clear a SARS-CoV-2 reservoir are accelerated.", "doi": "10.1038/s41590-023-01601-2", "pmid": "37667052", "labels": {"Category: Proteins": null, "Category: Post-COVID": null, "Type: Review": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41590-023-01601-2"}], "notes": [], "created": "2023-10-06T06:52:40.952Z", "modified": "2023-10-06T09:52:56.908Z"}, {"entity": "publication", "iuid": "d651eb1d97f847b39b096d2ba9a3e124", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d651eb1d97f847b39b096d2ba9a3e124.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d651eb1d97f847b39b096d2ba9a3e124"}}, "title": "Natural Course of Aortic Stenosis in Older Subjects: Effects of COVID-19.", "authors": [{"family": "Giani", "given": "Anna", "initials": "A"}, {"family": "Xu", "given": "Hong", "initials": "H"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}, {"family": "Fantin", "given": "Francesco", "initials": "F"}, {"family": "Zamboni", "given": "Mauro", "initials": "M"}, {"family": "B\u00e4ck", "given": "Magnus", "initials": "M"}, {"family": "Religa", "given": "Dorota", "initials": "D"}], "type": "observational study", "published": "2023-10-00", "journal": {"title": "J Am Med Dir Assoc", "issn": "1538-9375", "issn-l": null, "volume": "24", "issue": "10", "pages": "1594.e1-1594.e9"}, "abstract": "Both aortic stenosis (AS) and COVID-19 affect the morbidity and mortality burden among older adults. The aim of the study was to examine whether aortic stenosis (AS) affects the prognosis after SARS-CoV-2 infection and whether COVID-19 affects AS prognosis, in a cohort of older adults hospitalized with and without COVID-19.\r\n\r\nObservational study.\r\n\r\nPatients admitted to 9 geriatric clinics in Stockholm from March 2020 to November 2021.\r\n\r\nAS and COVID-19 diagnoses were identified by electronic health records; the outcomes were mortality at 30 days and any time during a median follow-up of 630 days. The associations between AS, COVID-19, and mortality were assessed by using Royston-Parmar models adjusting for age, sex, comorbidities, and admission waves.\r\n\r\nAmong 28,974 patients, 85 had concomitant AS and COVID-19, 529 had only AS, and 5033 had only COVID-19. Both at 30 days and at any time, as compared to patients without, concomitant AS and COVID-19 subjects had a higher mortality rate (438.4 per 100 py, 95% CI 296.2-648.8, and 72.9, 95% CI 53.7-99.0, respectively) and a higher death risk (adjusted HR 5.5, 95% CI 3.7-8.2; and 2.8, 95% CI 2.1-3.9). AS patients presented increased mortality HR both in the presence and absence of COVID-19 at 30 days (1.6, 95% CI 1.1-2.4; and 1.6, 95% CI 1.2-2.2, respectively) and at any time (1.6, 95% CI 1.1-2.1; 1.4, 95% CI 1.2-1.7, respectively).\r\n\r\nAS was a significant mortality risk factor, independent of concomitant COVID-19. Careful AS management should always be pursued, even in acute and post-acute phases of COVID-19.", "doi": "10.1016/j.jamda.2023.07.026", "pmid": "37696497", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1525-8610(23)00715-6"}], "notes": [], "created": "2023-10-06T06:52:25.240Z", "modified": "2023-10-06T09:12:40.597Z"}, {"entity": "publication", "iuid": "de85b64233bf4afc904771cebd31acd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/de85b64233bf4afc904771cebd31acd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/de85b64233bf4afc904771cebd31acd0"}}, "title": "Myoclonus in patients with COVID-19: Findings of autoantibodies against brain structures in cerebrospinal fluid.", "authors": [{"family": "Lindqvist", "given": "Isa", "initials": "I"}, {"family": "Cunningham", "given": "Janet L", "initials": "JL"}, {"family": "Mulder", "given": "Jan", "initials": "J"}, {"family": "Feresiadou", "given": "Amalia", "initials": "A"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Virhammar", "given": "Johan", "initials": "J", "orcid": "0000-0001-9901-2949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9db4ac69a3e8495ea8e71ae60042fa5c.json"}}, {"family": "Kumlien", "given": "Eva", "initials": "E", "orcid": "0000-0002-1952-8791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de1d39588b21438fabae7d27acf4b237.json"}}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Eur J Neurol", "issn": "1468-1331", "issn-l": null, "volume": "30", "issue": "10", "pages": "3142-3148"}, "abstract": "COVID-19 is associated with multiple neurological manifestations. The clinical presentation, trajectory, and treatment response for three cases of myoclonus during COVID-19 infection, with no previous neurological disease, are decsribed.\r\n\r\nAnalysis of cerebrospinal fluid from the cases using indirect immunohistochemistry.\r\n\r\nAntibodies against rodent brain tissue, and similarities in staining patterns were observed, indicating the presence of antineuronal immunoglobulin G autoantibodies targeting astrocytes in the hippocampus.\r\n\r\nOur results demontrate cerebrospinal fluid antineuronal antibodies indicating an an autoimmune involvment in the pathogenesis in COVID-19 associated myoclonus.", "doi": "10.1111/ene.15958", "pmid": "37392418", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:08:31.262Z", "modified": "2023-10-04T12:37:06.510Z"}, {"entity": "publication", "iuid": "d7511b5121ee45ec86cddd07349547ea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d7511b5121ee45ec86cddd07349547ea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d7511b5121ee45ec86cddd07349547ea"}}, "title": "Molnupiravir compared to nirmatrelvir/ritonavir for COVID-19 in high-risk patients with haematological malignancy in Europe. A matched-paired analysis from the EPICOVIDEHA registry.", "authors": [{"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J"}, {"family": "Marchesi", "given": "Francesco", "initials": "F"}, {"family": "Koehler", "given": "Philipp", "initials": "P"}, {"family": "Weinbergerov\u00e1", "given": "Barbora", "initials": "B"}, {"family": "\u010colovi\u0107", "given": "Natasa", "initials": "N"}, {"family": "Falces-Romero", "given": "Iker", "initials": "I"}, {"family": "Buquicchio", "given": "Caterina", "initials": "C"}, {"family": "Farina", "given": "Francesca", "initials": "F"}, {"family": "van Praet", "given": "Jens", "initials": "J"}, {"family": "Biernat", "given": "Monika M", "initials": "MM"}, {"family": "Itri", "given": "Federico", "initials": "F"}, {"family": "Prezioso", "given": "Lucia", "initials": "L"}, {"family": "Tascini", "given": "Carlo", "initials": "C"}, {"family": "Vena", "given": "Antonio", "initials": "A"}, {"family": "Romano", "given": "Alessandra", "initials": "A"}, {"family": "Delia", "given": "Mario", "initials": "M"}, {"family": "D\u00e1vila-Valls", "given": "Julio", "initials": "J"}, {"family": "Mart\u00edn-P\u00e9rez", "given": "Sonia", "initials": "S"}, {"family": "Lavilla-Rubira", "given": "Esperanza", "initials": "E"}, {"family": "Ad\u017ei\u0107-Vuki\u010devi\u0107", "given": "Tatjana", "initials": "T"}, {"family": "Garc\u00eda-Bordallo", "given": "Daniel", "initials": "D"}, {"family": "L\u00f3pez-Garc\u00eda", "given": "Alberto", "initials": "A"}, {"family": "Criscuolo", "given": "Mariana", "initials": "M"}, {"family": "Petzer", "given": "Verena", "initials": "V"}, {"family": "Fracchiolla", "given": "Nicola S", "initials": "NS"}, {"family": "Espigado", "given": "Ildefonso", "initials": "I"}, {"family": "Sili", "given": "Uluhan", "initials": "U"}, {"family": "Meers", "given": "Stef", "initials": "S"}, {"family": "Erben", "given": "Nurettin", "initials": "N"}, {"family": "Cattaneo", "given": "Chiara", "initials": "C"}, {"family": "Tragiannidis", "given": "Athanasios", "initials": "A"}, {"family": "Gavriilaki", "given": "Eleni", "initials": "E"}, {"family": "Sch\u00f6nlein", "given": "Martin", "initials": "M"}, {"family": "Mitrovic", "given": "Mirjana", "initials": "M"}, {"family": "Pantic", "given": "Nikola", "initials": "N"}, {"family": "Merelli", "given": "Maria", "initials": "M"}, {"family": "Labrador", "given": "Jorge", "initials": "J"}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jos\u00e9-\u00c1ngel", "initials": "J"}, {"family": "Glenth\u00f8j", "given": "Andreas", "initials": "A"}, {"family": "Fouquet", "given": "Guillemette", "initials": "G"}, {"family": "Del Principe", "given": "Maria Ilaria", "initials": "MI"}, {"family": "Dargenio", "given": "Michelina", "initials": "M"}, {"family": "Calbacho", "given": "Mar\u00eda", "initials": "M"}, {"family": "Besson", "given": "Caroline", "initials": "C"}, {"family": "Kohn", "given": "Milena", "initials": "M"}, {"family": "Gr\u00e4fe", "given": "Stefanie", "initials": "S"}, {"family": "Hersby", "given": "Ditte Stampe", "initials": "DS"}, {"family": "Arellano", "given": "Elena", "initials": "E"}, {"family": "\u00c7olak", "given": "G\u00f6k\u00e7e Melis", "initials": "GM"}, {"family": "Wolf", "given": "Dominik", "initials": "D"}, {"family": "Marchetti", "given": "Monia", "initials": "M"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Cordoba", "given": "Raul", "initials": "R"}, {"family": "Mi\u0161kovi\u0107", "given": "Bojana", "initials": "B"}, {"family": "Mladenovi\u0107", "given": "Milo\u0161", "initials": "M"}, {"family": "Bavastro", "given": "Martina", "initials": "M"}, {"family": "Limongelli", "given": "Alessandro", "initials": "A"}, {"family": "Rahimli", "given": "Laman", "initials": "L"}, {"family": "Pagano", "given": "Livio", "initials": "L"}, {"family": "Cornely", "given": "Oliver A", "initials": "OA"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Int J Antimicrob Agents", "issn": "1872-7913", "issn-l": null, "volume": "62", "issue": "4", "pages": "106952"}, "abstract": "Molnupiravir and nirmatrelvir/ritonavir are antivirals used to prevent progression to severe SARS-CoV-2 infections and decrease hospitalisation and mortality rates. Nirmatrelvir/ritonavir was authorised in Europe in December 2021, whereas molnupiravir is not yet licensed in Europe as of February 2022. Molnupiravir may be an alternative to nirmatrelvir/ritonavir because it is associated with fewer drug-drug interactions and contraindications. A caveat for molnupiravir is the mode of action induces viral mutations. Mortality rate reduction with molnupiravir was less pronounced than that with nirmatrelvir/ritonavir in patients without haematological malignancy. Little is known about the comparative efficacy of the two drugs in patients with haematological malignancy at high-risk of severe COVID-19. Thus, molnupiravir and nirmatrelvir/ritonavir were compared in a cohort of patients with haematological malignancies.\r\n\r\nClinical data from patients treated with molnupiravir or nirmatrelvir/ritonavir monotherapy for COVID-19 were retrieved from the EPICOVIDEHA registry. Patients treated with molnupiravir were matched by sex, age (\u00b110 years), and severity of baseline haematological malignancy to controls treated with nirmatrelvir/ritonavir.\r\n\r\nA total of 116 patients receiving molnupiravir for the clinical management of COVID-19 were matched to an equal number of controls receiving nirmatrelvir/ritonavir. In each of the groups, 68 (59%) patients were male; with a median age of 64 years (interquartile range [IQR] 53-74) for molnupiravir recipients and 64 years (IQR 54-73) for nirmatrelvir/ritonavir recipients; 56.9% (n=66) of the patients had controlled baseline haematological malignancy, 12.9% (n=15) had stable disease, and 30.2% (n=35) had active disease at COVID-19 onset in each group. During COVID-19 infection, one third of patients from each group were admitted to hospital. Although a similar proportion of patients in the two groups were vaccinated (molnupiravir n=77, 66% vs. nirmatrelvir/ritonavir n=87, 75%), more of those treated with nirmatrelvir/ritonavir had received four vaccine doses (n=27, 23%) compared with those treated with molnupiravir (n=5, 4%) (P<0.001). No differences were detected in COVID-19 severity (P=0.39) or hospitalisation (P=1.0). No statistically significant differences were identified in overall mortality rate (P=0.78) or survival probability (d30 P=0.19, d60 P=0.67, d90 P=0.68, last day of follow up P=0.68). Deaths were either attributed to COVID-19, or the infection was judged by the treating physician to have contributed to death.\r\n\r\nHospitalisation and mortality rates with molnupiravir were comparable to those with nirmatrelvir/ritonavir in high-risk patients with haematological malignancies and COVID-19. Molnupiravir is a plausible alternative to nirmatrelvir/ritonavir for COVID-19 treatment in patients with haematological malignancy.", "doi": "10.1016/j.ijantimicag.2023.106952", "pmid": "37582478", "labels": {"Category: Health": null, "Type: Journal article": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pii", "key": "S0924-8579(23)00231-5"}], "notes": [], "created": "2023-10-05T08:02:33.837Z", "modified": "2023-10-05T08:46:11.473Z"}, {"entity": "publication", "iuid": "25d827196a0f4fc1a51bd72da008cfd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/25d827196a0f4fc1a51bd72da008cfd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/25d827196a0f4fc1a51bd72da008cfd0"}}, "title": "Implementation of a broad public health approach to COVID-19 in Sweden, January 2020 to May 2022.", "authors": [{"family": "Tegnell", "given": "Anders", "initials": "A"}, {"family": "Bess\u00f6", "given": "Anna", "initials": "A"}, {"family": "Bj\u00f6rkholm", "given": "Britta", "initials": "B"}, {"family": "Byfors", "given": "Sara", "initials": "S"}, {"family": "Carlson", "given": "Johan", "initials": "J"}, {"family": "Tegmark Wisell", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "41", "pages": null}, "abstract": "In 2020, the world had to adapt to a pandemic caused by a then novel coronavirus. In addition to its direct impact on morbidity and mortality, the COVID-19 pandemic brought unprecedented control measures and challenges to both individuals and society. Sweden has been seen by many as an outlier in the management of the pandemic. It is therefore of special interest to document the actual management of the pandemic in Sweden during its first 2 years and how public health was affected. In the authors opinion, within the Swedish context, it has been possible to achieve a similar level of effect on mortality and morbidity through recommendations as was achieved through stringent legal measures in comparable countries. This is supported by comparisons of excess mortality that have been published. Furthermore, we see in the available data that the consequences on mental health and living habits were very limited for the majority of the population. Trust in public institutions is high in Sweden, which has been important and is part of the context that made it possible to manage a pandemic with relatively 'soft' measures. We acknowledge challenges in protecting certain vulnerable groups, particularly during the first and second wave.", "doi": "10.2807/1560-7917.ES.2023.28.41.2300063", "pmid": "37824250", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10571492"}], "notes": [], "created": "2023-11-01T13:33:32.026Z", "modified": "2023-11-02T07:23:36.114Z"}, {"entity": "publication", "iuid": "f901d9ad7f8c4b3090a20cf79c347f86", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f901d9ad7f8c4b3090a20cf79c347f86.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f901d9ad7f8c4b3090a20cf79c347f86"}}, "title": "Healthcare workers' experiences of patient safety in the intensive care unit during the COVID-19 pandemic: A multicentre qualitative study.", "authors": [{"family": "Berggren", "given": "Karin", "initials": "K"}, {"family": "Ekstedt", "given": "Mirjam", "initials": "M", "orcid": "0000-0002-4108-391X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd3b314aef4646a5b54fa1132735d1ff.json"}}, {"family": "Joelsson-Alm", "given": "Eva", "initials": "E", "orcid": "0000-0002-9041-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07a091265e654b21bc27fa14b93e4ec0.json"}}, {"family": "Swedberg", "given": "Lena", "initials": "L"}, {"family": "Sackey", "given": "Peter", "initials": "P"}, {"family": "Schandl", "given": "Anna", "initials": "A", "orcid": "0000-0002-3603-1912", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e848555095e546cba3cfcfd8d4609064.json"}}], "type": "multicenter study", "published": "2023-10-00", "journal": {"title": "J Clin Nurs", "issn": "1365-2702", "issn-l": null, "volume": "32", "issue": "19-20", "pages": "7372-7381"}, "abstract": "To describe healthcare workers' experiences of preconditions and patient safety risks in intensive care units during the COVID-19 pandemic.\r\n\r\nHealthcare workers' ability to adapt to changing conditions is crucial to promote patient safety. During the COVID-19 pandemic, healthcare workers' capacity to maintain safe care was challenged and a more in-depth understanding on frontline experiences of patient safety is needed.\r\n\r\nA qualitative descriptive design.\r\n\r\nIndividual interviews were conducted with 29 healthcare workers (nurses, physicians, nurse assistants and physiotherapists) from three Swedish hospitals directly involved in intensive care of COVID-19 patients. Data were analysed with inductive content analysis. Reporting followed the COREQ checklist.\r\n\r\nThree categories were identified. Hazardous changes in working conditions describes patient safety challenges associated with the extreme workload with high stress level. Imperative adaptations induced by changed preconditions for patient safety which include descriptions of safety risks following adaptations related to temporary intensive care facilities, handling shortage of medical equipment and deviations from routines. Safety risks triggered by reorganisation of care describe how the diluted skill-mix and team disruptions exposed patients to safety risks, and that safety performance mostly relied on individual healthcare worker's responsibility.\r\n\r\nThe study suggests that healthcare workers experienced an increase in patient safety risks during the COVID-19 pandemic mainly because the extremely high workload, imperative adaptations, and reorganisation of care regarding skill-mix and teamwork. Patient safety performance relied on the individuals' adaptability and responsibility rather than on system-based safety.\r\n\r\nThis study provides insights on how healthcare workers' experiences can be used as a source of information for recognition of patient safety risks. To improve detection of safety risks during future crises, guidelines on how to approach safety from a system perspective must include healthcare workers' perceptions on safety risks.\r\n\r\nNone in the conceptualisation or design of the study.", "doi": "10.1111/jocn.16793", "pmid": "37291795", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:31:11.760Z", "modified": "2023-10-04T10:45:26.906Z"}, {"entity": "publication", "iuid": "09ec3219c27546cc8c01c94f93fb7933", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/09ec3219c27546cc8c01c94f93fb7933.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/09ec3219c27546cc8c01c94f93fb7933"}}, "title": "GLOBAL RETROSPECTIVE REVIEW OF SEVERE ACUTE RESPIRATORY SYNDROME SARS COV-2 INFECTIONS IN NONDOMESTIC FELIDS: MARCH 2020-FEBRUARY 2021.", "authors": [{"family": "Bartlett", "given": "Susan L", "initials": "SL"}, {"family": "Koeppel", "given": "Katja N", "initials": "KN"}, {"family": "Cushing", "given": "Andrew C", "initials": "AC"}, {"family": "Bellon", "given": "Hugo Fern\u00e1ndez", "initials": "HF"}, {"family": "Almagro", "given": "Vanessa", "initials": "V"}, {"family": "Gyimesi", "given": "Zoltan S", "initials": "ZS"}, {"family": "Thies", "given": "Tammy", "initials": "T"}, {"family": "H\u00e5rd", "given": "Therese", "initials": "T"}, {"family": "Denitton", "given": "Daniel", "initials": "D"}, {"family": "Fox", "given": "Kami Z", "initials": "KZ"}, {"family": "Vodi\u010dka", "given": "Roman", "initials": "R"}, {"family": "Wang", "given": "Leyi", "initials": "L"}, {"family": "Calle", "given": "Paul P", "initials": "PP"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "J Zoo Wildl Med", "issn": "1042-7260", "issn-l": null, "volume": "54", "issue": "3", "pages": "607-616"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in nondomestic felids have been documented in North America, South America, Africa, Europe, and Asia. Between March 2020 and February 2021, at nine institutions across three continents, infection was confirmed in 16 tigers (Panthera tigris), 14 lions (Panthera leo), three snow leopards (Panthera uncia), one cougar (Puma concolor), and one Amur leopard cat (Prionailurus bengalensis euptilurus) ranging from 2 to 21 yr old (average, 10 yr). Infection was suspected in an additional 12 tigers, 4 lions, and 9 cougars. Clinical signs (in order of most to least common) included coughing, ocular and/or nasal discharge, wheezing, sneezing, decreased appetite, lethargy, diarrhea, and vomiting. Most felids recovered uneventfully, but one geriatric tiger with comorbidities developed severe dyspnea and neurologic signs necessitating euthanasia. Clinical signs lasted 1-19 d (average, 8 d); one tiger was asymptomatic. Infection was confirmed by various methods, including antigen tests and/or polymerase chain reaction (PCR) of nasal or oral swabs, tracheal wash, and feces, or virus isolation from feces or tracheal wash. Infection status and resolution were determined by testing nasal swabs from awake animals, fecal PCR, and observation of clinical signs. Shedding of fecal viral RNA was significantly longer than duration of clinical signs. Postinfection seropositivity was confirmed by four institutions including 11 felids (5 lions, 6 tigers). In most instances, asymptomatic or presymptomatic keepers were the presumed or confirmed source of infection, although in some instances the infection source remains uncertain. Almost all infections occurred despite using cloth facemasks and disposable gloves when in proximity to the felids and during food preparation. Although transmission may have occurred during momentary lapses in personal protective equipment compliance, it seems probable that cloth masks are insufficient at preventing transmission of SARS-CoV-2 from humans to nondomestic felids. Surgical or higher grade masks may be warranted when working with nondomestic felids.", "doi": "10.1638/2022-0141", "pmid": "37817628", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:34:22.162Z", "modified": "2023-11-02T07:50:14.136Z"}, {"entity": "publication", "iuid": "b3b031004380472dab4d6dab50438f3a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b3b031004380472dab4d6dab50438f3a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b3b031004380472dab4d6dab50438f3a"}}, "title": "Effect of the SARS-CoV-2 pandemic on planned and emergency hernia repair in Sweden: a register-based study.", "authors": [{"family": "Ali", "given": "Fathalla", "initials": "F", "orcid": "0000-0002-2090-4563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db5cc2ac937040a497cc3ca444a2b84c.json"}}, {"family": "Sandblom", "given": "Gabriel", "initials": "G"}, {"family": "Fathalla", "given": "Blend", "initials": "B"}, {"family": "Wallin", "given": "G\u00f6ran", "initials": "G"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Hernia", "issn": "1248-9204", "issn-l": null, "volume": "27", "issue": "5", "pages": "1103-1108"}, "abstract": "The COVID-19 has had a profound impact on the health care delivery in Sweden, including deprioritization of benign surgeries during the COVID-19 pandemic. The aim of this study was to assess the effect of COVID-19 pandemic on emergency and planned hernia repair in Sweden.\r\n\r\nData on hernia repairs from January 2016 to December 2021 were retrieved from the Swedish Patient Register using procedural codes. Two groups were formed: COVID-19 group (January 2020-December 2021) and control group (January 2016-December 2019). Demographic data on mean age, gender, and type of hernia were collected.\r\n\r\nThis study showed a weak negative correlation between the number of elective hernia repairs performed each month during the pandemic and the number of emergency repairs carried out during the following 3 months for inguinal hernia repair (p = 0.114) and incisional hernia repair (p = 0.193), whereas there was no correlation for femoral or umbilical hernia repairs.\r\n\r\nThe COVID-19 pandemic had a great impact on planned hernia surgeries in Sweden, but our hypothesis that postponing planned repairs would increase the risk of emergency events was not supported.", "doi": "10.1007/s10029-023-02828-6", "pmid": "37418049", "labels": {"Category: Other": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10533583"}, {"db": "pii", "key": "10.1007/s10029-023-02828-6"}], "notes": [], "created": "2023-10-04T12:08:23.566Z", "modified": "2023-10-04T12:34:22.585Z"}, {"entity": "publication", "iuid": "dfed0a9f25d144c7ae8d1907acc1f19f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dfed0a9f25d144c7ae8d1907acc1f19f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dfed0a9f25d144c7ae8d1907acc1f19f"}}, "title": "Catch-up antibody responses and hybrid immunity in mRNA vaccinated patients at risk of severe COVID-19.", "authors": [{"family": "Al-Dury", "given": "Samer", "initials": "S"}, {"family": "Waldenstr\u00f6m", "given": "Jesper", "initials": "J", "orcid": "0000-0003-2234-0076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/191df8f505f044c28ca294008918db62.json"}}, {"family": "Ringlander", "given": "Johan", "initials": "J", "orcid": "0000-0002-8483-6504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64f85af7dceb436498422e62f1a98c89.json"}}, {"family": "Einarsdottir", "given": "Sigrun", "initials": "S", "orcid": "0000-0003-4756-6805", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cfc4ff4119cd4d1abbbce55d38311147.json"}}, {"family": "Andersson", "given": "Markus", "initials": "M"}, {"family": "Hamah Saed", "given": "Hevar", "initials": "H"}, {"family": "Waern", "given": "Johan", "initials": "J"}, {"family": "Martner", "given": "Anna", "initials": "A", "orcid": "0000-0002-6598-5221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c11a2e719c534772a129782bfb60d35c.json"}}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-6617-5976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7bda9f192dc44c587d8a252ef16516b.json"}}, {"family": "Lagging", "given": "Martin", "initials": "M", "orcid": "0000-0002-7995-3626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f059c2a808c46219b90ea780e413ad9.json"}}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": "55", "issue": "10", "pages": "744-750"}, "abstract": "The immunogenicity of repeated vaccination and hybrid immunity in vulnerable patients remains unclear.\r\n\r\nWe studied the impact of iterative Covid-19 mRNA vaccination and hybrid immunity on antibody levels in immunosuppressed subjects. Patients with liver cirrhosis (n = 38), survivors of allogeneic haematopoietic stem cell transplantation (allo-HSCT) (n = 36) and patients with autoimmune liver disease (n = 14) along with healthy controls (n = 20) were monitored for SARS-CoV-2-S1 IgG after their 1st-3rd vaccine doses, 31 of whom became infected with the Omicron variant after the 2nd dose. Ten uninfected allo-HSCT recipients received an additional 4th vaccine dose.\r\n\r\nUnexpectedly, immunosuppressed patients achieved antibody levels in parity with controls after the 3rd vaccine dose. In all study cohorts, hybrid immunity (effect of vaccination and natural infection) resulted in approximately 10-fold higher antibody levels than vaccine-induced immunity alone.\r\n\r\nThree doses of the Covid-19 mRNA vaccine entailed high antibody concentrations even in immunocompromised individuals, and hybrid-immunity resulted further augmented levels than vaccination alone. Clinical trial registration: EudraCT 2021-000349-42.", "doi": "10.1080/23744235.2023.2230289", "pmid": "37395287", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:07:48.708Z", "modified": "2023-10-04T12:26:01.724Z"}, {"entity": "publication", "iuid": "1930eed8da554f868ccdb3405dceb019", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1930eed8da554f868ccdb3405dceb019.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1930eed8da554f868ccdb3405dceb019"}}, "title": "Access to sexual and reproductive health services among South African young people living with and without HIV during the COVID-19 pandemic.", "authors": [{"family": "Giovenco", "given": "Danielle", "initials": "D"}, {"family": "Pettifor", "given": "Audrey", "initials": "A"}, {"family": "Itzikowitz", "given": "Gina", "initials": "G"}, {"family": "Chung", "given": "Stephanie", "initials": "S"}, {"family": "Qayiya", "given": "Yamkela", "initials": "Y"}, {"family": "K\u0227gesten", "given": "Anna E", "initials": "AE"}, {"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM"}, {"family": "Bekker", "given": "Linda-Gail", "initials": "L"}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Contraception", "issn": "1879-0518", "issn-l": null, "volume": "126", "issue": null, "pages": "110119"}, "abstract": "To examine sexual and reproductive health (SRH) service access among South African young people during the COVID-19 pandemic.\r\n\r\nWe utilized cross-sectional data collected from February to October 2021 in Cape Town among young people 13-24 years of age living with and without HIV.\r\n\r\nTwo hundred and fifteen young people living with HIV (YPLWH) and 320 young people living without HIV were included. Young people reported an unmet need for SRH services during COVID-19, and 28% of YPLWH reported missing an HIV care appointment during the COVID-19 lockdowns.\r\n\r\nExpanding access to SRH services for young people during disruptive events is critical to reduce disparities in HIV and other SRH outcomes.", "doi": "10.1016/j.contraception.2023.110119", "pmid": "37467919", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0010-7824(23)00209-3"}], "notes": [], "created": "2023-10-04T12:09:17.106Z", "modified": "2023-10-04T12:50:30.860Z"}, {"entity": "publication", "iuid": "14ceb83c4c3844969152393ee4b41045", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/14ceb83c4c3844969152393ee4b41045.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/14ceb83c4c3844969152393ee4b41045"}}, "title": "A meta-meta-analysis of co-infection, secondary infections, and antimicrobial resistance in COVID-19 patients.", "authors": [{"family": "Suleiman", "given": "Adeiza Shuaibu", "initials": "AS"}, {"family": "Islam", "given": "Md Aminul", "initials": "MA"}, {"family": "Akter", "given": "Mir Salma", "initials": "MS"}, {"family": "Amin", "given": "Mohammad Ruhul", "initials": "MR"}, {"family": "Werkneh", "given": "Adhena Ayaliew", "initials": "AA"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}], "type": "systematic review", "published": "2023-10-00", "journal": {"title": "J Infect Public Health", "issn": "1876-035X", "issn-l": null, "volume": "16", "issue": "10", "pages": "1562-1590"}, "abstract": "The newly discovered coronavirus SARS-CoV-2 has sparked a worldwide pandemic of COVID-19, which has caused havoc on medical infrastructures, economies, and cultures around the world. Determining the whole scenario is essential since SARS-CoV-2 variants and sub-variants keep appearing after vaccinations and booster doses. The objective of this secondary meta-analysis is to analysis co-infection, secondary infections, and antimicrobial resistance (AMR) in COVID-19 patients. This study used five significant databases to conduct a systematic review and an overlap meta-analysis to evaluate the pooled estimates of co-infections and secondary infections. The summary of the meta-analysis showed an overall co-infection effect of 26.19% (95% confidence intervals CI: 21.39-31.01, I2 =98.78, n = 14 meta-analysis) among patients with COVID-19. A coinfection effect of 11.13% (95% CI: 9.7-12.56, I2 =99.14, n = 11 meta-analysis) for bacteria; 9.69% (95% CI: 1.21-7.90, I2 =98.33) for fungal and 3.48% (95% CI: 2.15-4.81, I2 =95.84) for viruses. A secondary infection effect of 19.03% (95% CI: 9.53-28.54, I2 =85.65) was pooled from 2 meta-analyses (Ave: 82 primary studies). This is the first study that compiles the results of all the previous three years meta-analyses into a single source and offers strong proof of co-infections and secondary infections in COVID-19 patients. Early detection of co-infection and AMR is crucial for COVID-19 patients in order to effective treatment.", "doi": "10.1016/j.jiph.2023.07.005", "pmid": "37572572", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1876-0341(23)00240-X"}], "notes": [], "created": "2023-10-05T08:01:54.159Z", "modified": "2023-10-05T08:37:48.264Z"}, {"entity": "publication", "iuid": "5d52e0763b144d49bad1aa7e75f1746a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d52e0763b144d49bad1aa7e75f1746a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d52e0763b144d49bad1aa7e75f1746a"}}, "title": "A comparison of COVID-19 incidence rates across six European countries in 2021.", "authors": [{"family": "Padget", "given": "Michael", "initials": "M"}, {"family": "Adam", "given": "Pauline", "initials": "P"}, {"family": "Dorfmuller", "given": "Marina", "initials": "M"}, {"family": "Blondel", "given": "Clara", "initials": "C"}, {"family": "Campos-Matos", "given": "Ines", "initials": "I"}, {"family": "Fayad", "given": "Myriam", "initials": "M"}, {"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Mesher", "given": "David", "initials": "D"}, {"family": "Pistol", "given": "Adriana", "initials": "A"}, {"family": "Rebolledo", "given": "Javiera", "initials": "J"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Riess", "given": "Maximilian", "initials": "M"}, {"family": "Rusu", "given": "Lavinia Cipriana", "initials": "LC"}, {"family": "Che", "given": "Didier", "initials": "D"}, {"family": "Coignard", "given": "Bruno", "initials": "B"}, {"family": "COVID-19 Study group", "given": "", "initials": ""}, {"family": "COVID-19 Study Group members", "given": "", "initials": ""}], "type": "journal article", "published": "2023-10-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "40", "pages": null}, "abstract": "International comparisons of COVID-19 incidence rates have helped gain insights into the characteristics of the disease, benchmark disease impact, shape public health measures and inform potential travel restrictions and border control measures. However, these comparisons may be biased by differences in COVID-19 surveillance systems and approaches to reporting in each country. To better understand these differences and their impact on incidence comparisons, we collected data on surveillance systems from six European countries: Belgium, England, France, Italy, Romania and Sweden. Data collected included: target testing populations, access to testing, case definitions, data entry and management and statistical approaches to incidence calculation. Average testing, incidence and contextual data were also collected. Data represented the surveillance systems as they were in mid-May 2021. Overall, important differences between surveillance systems were detected. Results showed wide variations in testing rates, access to free testing and the types of tests recorded in national databases, which may substantially limit incidence comparability. By systematically including testing information when comparing incidence rates, these comparisons may be greatly improved. New indicators incorporating testing or existing indicators such as death or hospitalisation will be important to improving international comparisons.", "doi": "10.2807/1560-7917.ES.2023.28.40.2300088", "pmid": "37796443", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10557383"}], "notes": [], "created": "2023-11-01T13:33:22.545Z", "modified": "2023-11-02T07:18:16.856Z"}, {"entity": "publication", "iuid": "9c030619934c4fc3ae03dfc8cdbd0329", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9c030619934c4fc3ae03dfc8cdbd0329.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9c030619934c4fc3ae03dfc8cdbd0329"}}, "title": "Immunogenicity and safety of AZD2816, a beta (B.1.351) variant COVID-19 vaccine, and AZD1222 (ChAdOx1 nCoV-19) as third-dose boosters for previously vaccinated adults: a multicentre, randomised, partly double-blinded, phase 2/3 non-inferiority immunobridging study in the UK and Poland.", "authors": [{"family": "Ramasamy", "given": "Maheshi N", "initials": "MN"}, {"family": "Kelly", "given": "Elizabeth J", "initials": "EJ"}, {"family": "Seegobin", "given": "Seth", "initials": "S"}, {"family": "Dargan", "given": "Paul I", "initials": "PI"}, {"family": "Payne", "given": "Ruth", "initials": "R"}, {"family": "Libri", "given": "Vincenzo", "initials": "V"}, {"family": "Adam", "given": "Matthew", "initials": "M"}, {"family": "Aley", "given": "Parvinder K", "initials": "PK"}, {"family": "Martinez-Alier", "given": "Nuria", "initials": "N"}, {"family": "Church", "given": "Alison", "initials": "A"}, {"family": "Jepson", "given": "Brett", "initials": "B"}, {"family": "Khan", "given": "Mark", "initials": "M"}, {"family": "Matthews", "given": "Sam", "initials": "S"}, {"family": "Townsend", "given": "G Todd", "initials": "GT"}, {"family": "Vekemans", "given": "Johan", "initials": "J"}, {"family": "Bibi", "given": "Sagida", "initials": "S"}, {"family": "Swanson", "given": "Phillip A", "initials": "PA"}, {"family": "Lambe", "given": "Teresa", "initials": "T"}, {"family": "Pangalos", "given": "Menelas N", "initials": "MN"}, {"family": "Villafana", "given": "Tonya", "initials": "T"}, {"family": "Pollard", "given": "Andrew J", "initials": "AJ"}, {"family": "Green", "given": "Justin A", "initials": "JA"}, {"family": "AZD2816 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-09-29", "journal": {"title": "The Lancet Microbe", "issn": "2666-5247", "issn-l": "2666-5247", "volume": null, "issue": null, "pages": null}, "abstract": "This study aimed to evaluate AZD2816, a variant-updated COVID-19 vaccine expressing the full-length SARS-CoV-2 beta (B.1.351) variant spike protein that is otherwise similar to AZD1222 (ChAdOx1 nCoV-19), and AZD1222 as third-dose boosters.\r\n\r\nThis phase 2/3, partly double-blinded, randomised, active-controlled study was done at 19 sites in the UK and four in Poland. Adult participants who had received a two-dose AZD1222 or mRNA vaccine primary series were randomly assigned by means of an Interactive Response Technology-Randomisation and Trial Supply Management system (1:1 within each primary-series cohort, stratified by age, sex, and comorbidities) to receive AZD1222 or AZD2816 (intramuscular injection; 5 \u00d7 1010 viral particles). Participants, investigators, and all sponsor staff members involved in study conduct were masked to randomisation. AZD1222 and AZD2816 doses were prepared by unmasked study staff members. The primary objectives were to evaluate safety and humoral immunogenicity (non-inferiority of day-29 pseudovirus neutralising antibody geometric mean titre [GMT] against ancestral SARS-CoV-2: AZD1222 booster vs AZD1222 primary series [historical controls]; margin 0\u00b767; SARS-CoV-2-seronegative participants). This study is registered with ClinicalTrials.gov, NCT04973449, and is completed.\r\n\r\nBetween June 27 and Sept 30, 2021, 1394 participants of the 1741 screened were randomly assigned to AZD1222 or AZD2816 following an AZD1222 (n=373, n=377) or mRNA vaccine (n=322, n=322) primary series. In SARS-CoV-2-seronegative participants receiving AZD1222 or AZD2816, 78% and 80% (AZD1222 primary series) and 90% and 93%, respectively (mRNA vaccine primary series) reported solicited adverse events to the end of day 8; 2%, 2%, 1%, and 1% had serious adverse events and 12%, 12%, 10%, and 11% had adverse events of special interest, respectively, to the end of day 180. The primary immunogenicity non-inferiority endpoint was met: day-29 neutralising antibody GMT ratios (ancestral SARS-CoV-2) were 1\u00b702 (95% CI 0\u00b790-1\u00b714) and 3\u00b747 (3\u00b709-3\u00b789) with AZD1222 booster versus historical controls (AZD1222 and mRNA vaccine primary series, respectively). Responses against beta were greater with AZD2816 versus AZD1222 (GMT ratios, AZD1222, mRNA vaccine primary series 1\u00b784 [1\u00b763-2\u00b708], 2\u00b722 [1\u00b799-2\u00b747]).\r\n\r\nBoth boosters were well tolerated, with immunogenicity against ancestral SARS-CoV-2 similar to AZD1222 primary-series vaccination. AZD2816 gave greater immune responses against beta versus AZD1222.\r\n\r\nAstraZeneca.", "doi": "10.1016/S2666-5247(23)00177-5", "pmid": "37783221", "labels": {"Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2666-5247(23)00177-5"}, {"db": "ClinicalTrials.gov", "key": "NCT04973449"}], "notes": [], "created": "2023-11-01T13:32:28.537Z", "modified": "2023-11-02T07:07:24.695Z"}, {"entity": "publication", "iuid": "27e0d5700ad1481da547ca6ce00cc480", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27e0d5700ad1481da547ca6ce00cc480.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27e0d5700ad1481da547ca6ce00cc480"}}, "title": "High-Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure due to COVID-19: A Multicenter Phase 2 Trial.", "authors": [{"family": "Di Fenza", "given": "Raffaele", "initials": "R", "orcid": "0000-0002-5675-7139", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bcbe9c9fe5f847fabd8d6e53c1b2ea60.json"}}, {"family": "Shetty", "given": "Naman S", "initials": "NS"}, {"family": "Gianni", "given": "Stefano", "initials": "S", "orcid": "0000-0002-0838-3654", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8a1132dcdb545a295319cb92c8d1557.json"}}, {"family": "Parcha", "given": "Vibhu", "initials": "V"}, {"family": "Giammatteo", "given": "Valentina", "initials": "V"}, {"family": "Safaee Fakhr", "given": "Bijan", "initials": "B"}, {"family": "Tornberg", "given": "Daniel", "initials": "D"}, {"family": "Wall", "given": "Olof", "initials": "O"}, {"family": "Harbut", "given": "Piotr", "initials": "P"}, {"family": "Lai", "given": "Peggy S", "initials": "PS", "orcid": "0000-0001-9501-8606", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b173a83f2ea442788446cd145854b2c.json"}}, {"family": "Li", "given": "Jonathan Z", "initials": "JZ"}, {"family": "Paganoni", "given": "Sabrina", "initials": "S"}, {"family": "Cenci", "given": "Stefano", "initials": "S"}, {"family": "Mueller", "given": "Ariel L", "initials": "AL"}, {"family": "Houle", "given": "Timothy T", "initials": "TT"}, {"family": "Akeju", "given": "Oluwaseun", "initials": "O"}, {"family": "Bittner", "given": "Edward A", "initials": "EA"}, {"family": "Bose", "given": "Somnath", "initials": "S"}, {"family": "Scott", "given": "Louie K", "initials": "LK"}, {"family": "Carroll", "given": "Ryan W", "initials": "RW", "orcid": "0000-0002-7513-7023", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/394cd170a6fc4f418d6849a6e4c694f8.json"}}, {"family": "Ichinose", "given": "Fumito", "initials": "F"}, {"family": "Hedenstierna", "given": "Magnus", "initials": "M"}, {"family": "Arora", "given": "Pankaj", "initials": "P"}, {"family": "Berra", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-2702-2093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b2fe95c4fbc402884a22f1d83931708.json"}}], "type": "journal article", "published": "2023-09-29", "journal": {"title": "Am J Respir Crit Care Med", "issn": "1535-4970", "issn-l": "1073-449X", "volume": null, "issue": null, "pages": null}, "abstract": "The effects of high-dose inhaled nitric oxide on hypoxemia in COVID-19 acute respiratory failure are unknown.\r\n\r\nMechanically ventilated adults with COVID-19 pneumonia were enrolled in a phase II, multicenter, single-blind, randomized, controlled, parallel-arm trial. Participants in the intervention arm received inhaled nitric oxide at 80 parts-per-million (ppm) for 48h, compared with the control group receiving usual care (without placebo). The primary outcome was the change in arterial oxy-genation (PaO2/FiO2) at 48h. The secondary outcomes included: time to reach a PaO2/FiO2>300 mmHg for at least 24h, the proportion of participants with a PaO2/FiO2>300 mmHg at 28 days, and survival at 28- and 90-days.\r\n\r\n193 participants were included in the modified intention-to-treat analysis. The mean change in PaO2/FiO2 ratio at 48h was 28.3 mmHg in the intervention group and -1.4 mmHg in the control group (mean difference: 39.1 mmHg (95%CrI:18.1-60.3). The mean time to reach a PaO2/FiO2>300 mmHg in the interventional group was 8.7 days com-pared to 8.4 days for the control group (mean difference:0.44(95%CrI:-3.63 to 4.53)). At 28 days, the proportion of participants attaining a PaO2/FiO2>300 mmHg was 27.7% in the inhaled nitric oxide group and 17.2% in the controls (RR:2.03(95%CrI:1.11 to 3.86)). Duration of ventilation and mortality at 28 and 90 days did not differ. No serious adverse events were reported.\r\n\r\nThe use of high-dose inhaled nitric oxide resulted in an improvement of PaO2/FiO2 at 48h compared with usual care in adults with acute hypoxemic respiratory failure due to COVID-19. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/). Clinical trial registration available at www.\r\n\r\ngov, ID: NCT04306393.", "doi": "10.1164/rccm.202304-0637OC", "pmid": "37774011", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT04306393"}], "notes": [], "created": "2023-10-06T06:57:10.441Z", "modified": "2023-10-06T11:38:31.714Z"}, {"entity": "publication", "iuid": "032ae9a98555402d8605ba6cadfbad32", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/032ae9a98555402d8605ba6cadfbad32.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/032ae9a98555402d8605ba6cadfbad32"}}, "title": "Comparative study between virus neutralisation testing and other serological methods detecting anti-SARS-CoV-2 antibodies in Europe, 2021.", "authors": [{"family": "M\u00f6gling", "given": "Ramona", "initials": "R"}, {"family": "Reimerink", "given": "Johan", "initials": "J"}, {"family": "Stanoeva", "given": "Kamelia R", "initials": "KR"}, {"family": "Keramarou", "given": "Maria", "initials": "M"}, {"family": "Guiomar", "given": "Raquel", "initials": "R"}, {"family": "Costa", "given": "In\u00eas", "initials": "I"}, {"family": "Haveri", "given": "Anu", "initials": "A"}, {"family": "Holzer", "given": "Barbara", "initials": "B"}, {"family": "Korukluo\u011flu", "given": "G\u00fclay", "initials": "G"}, {"family": "Nguyen", "given": "Trung", "initials": "T"}, {"family": "Pakarna", "given": "Gatis", "initials": "G"}, {"family": "Pancer", "given": "Katarzyna", "initials": "K"}, {"family": "Trilar", "given": "Katarina Prosenc", "initials": "KP"}, {"family": "Protic", "given": "Jelena", "initials": "J"}, {"family": "Stojanovi\u0107", "given": "Marijana", "initials": "M"}, {"family": "De Santis", "given": "Riccardo", "initials": "R"}, {"family": "Lista", "given": "Florigio", "initials": "F"}, {"family": "Vremera", "given": "Teodora", "initials": "T"}, {"family": "Leustean", "given": "Mihaela", "initials": "M"}, {"family": "Pistol", "given": "Adriana", "initials": "A"}, {"family": "Zelena", "given": "Hana", "initials": "H"}, {"family": "Reusken", "given": "Chantal", "initials": "C"}, {"family": "Broberg", "given": "Eeva K", "initials": "EK"}], "type": "journal article", "published": "2023-09-29", "journal": {"title": "J Virol Methods", "issn": "1879-0984", "issn-l": null, "volume": "322", "issue": null, "pages": "114825"}, "abstract": "One consequence of the ongoing coronavirus disease pandemic was the rapid development of both in-house and commercial serological assays detecting anti-SARS-CoV-2 antibodies, in an effort to reliably detect acute and past SARS-CoV-2 infections. It is crucial to evaluate the quality of these serological tests and consequently the sero-epidemiological studies that are performed with the respective tests. Here, we describe the set-up and results of a comparative study, in which a laboratory contracted by the European Centre for Disease Prevention and Control offered a centralised service to EU/EEA Member and pre-accession Member States to test representative serum specimens with known serological results, with the gold standard technique (virus neutralisation tests) to determine the presence of neutralising antibodies. Laboratories from 12 European countries shared 719 serum specimens with the contractor laboratory. We found that in-house serological tests detecting neutralising antibodies showed the highest percent agreement, both positive and negative, with the virus neutralisation test results. Despite extensive differences in virus neutralisation protocols neutralisation titres showed a strong correlation. From the commercial assays, the best positive percent agreement was found for SARS-CoV-2 IgG (sCOVG) (Siemens - Atellica IM Analyzer). Despite lower positive percent agreement of LIAISON SARS-CoV-2 TrimericS IgG kit (Diasorin Inc.), the obtained results showed relatively good correlation with neutralisation titres. The set-up of this study allowed for high comparability between laboratories and enabled laboratories that do not have the capacity or capability to perform VNTs themselves. Given the variety of in-house protocols detecting SARS-CoV-2 specific neutralising antibodies, including the virus strain, it could be of interest to select reference isolates for SARS-CoV-2 diagnostic to be made available for interested EU Member States and pre-accession countries.", "doi": "10.1016/j.jviromet.2023.114825", "pmid": "37778539", "labels": {"Category: Biochemistry": null, "Category: Serology": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0166-0934(23)00150-7"}], "notes": [], "created": "2023-11-01T13:34:01.625Z", "modified": "2023-11-02T07:39:20.575Z"}, {"entity": "publication", "iuid": "36ec5251e59b4ffbb0ba152f3d9aecb7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/36ec5251e59b4ffbb0ba152f3d9aecb7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/36ec5251e59b4ffbb0ba152f3d9aecb7"}}, "title": "Changes in stroke and TIA admissions during the COVID-19 pandemic: A meta-analysis.", "authors": [{"family": "Gunnarsson", "given": "Karin", "initials": "K"}, {"family": "Tofiq", "given": "Avin", "initials": "A", "orcid": "0000-0003-1712-7510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1460dc1501cf4a599430688991f6139f.json"}}, {"family": "Mathew", "given": "Alen", "initials": "A"}, {"family": "Cao", "given": "Yang", "initials": "Y", "orcid": "0000-0002-3552-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7594ca0fdf2d4f238ca04a788a405cdb.json"}}, {"family": "von Euler", "given": "Mia", "initials": "M"}, {"family": "Str\u00f6m", "given": "Jakob O", "initials": "JO"}], "type": "journal article", "published": "2023-09-29", "journal": {"title": "Eur Stroke J", "issn": "2396-9881", "issn-l": null, "volume": null, "issue": null, "pages": "23969873231204127"}, "abstract": "To perform a meta-analysis on how the admissions of stroke and transient ischemic attack (TIA) changed during the Corona Virus infection-19 (COVID-19) pandemic and evaluate if the effect was depending on stroke severity.\r\n\r\nObservational cohort studies comparing the number of stroke and/or TIA admissions during a period of the pandemic compared to a period before the pandemic were identified in PubMed and Embase. After excluding studies with overlapping populations and studies without satisfactory case ascertainment, data was extracted and meta-analyzed.\r\n\r\nA total of 59 studies were included. During the pandemic, there was a decrease in admissions of ischemic stroke (admission rate ratio (ARR) = 0.77, 95% confidence interval (CI): 0.72, 0.82), intracerebral hemorrhage (ARR = 0.79, 95% CI: 0.70, 0.90) and TIA (ARR = 0.66, 95% CI: 0.58, 0.75). Albeit admission rates of both mild (ARR = 0.61, 95% CI: 0.49, 0.77) and severe (ARR = 0.82, 95% CI = 0.71, 0.95) strokes decreased, milder strokes decreased more (proportion ratio (PR) = 0.76, 95% CI: 0.65, 0.89).\r\n\r\nPotential causes for the admission reduction could be strict prioritizations within the health care, patients' fear of acquiring COVID-19, or decreased access to health care due to lockdowns.\r\n\r\nDuring the COVID-19 pandemic, there was a reduction in admissions of stroke and TIA, possibly caused by reluctance to seek medical care.", "doi": "10.1177/23969873231204127", "pmid": "37776062", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-11-01T13:32:25.891Z", "modified": "2023-11-02T07:06:00.857Z"}, {"entity": "publication", "iuid": "89f03addb5ce4c9e9e0d934e562cefec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/89f03addb5ce4c9e9e0d934e562cefec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/89f03addb5ce4c9e9e0d934e562cefec"}}, "title": "The Impact of the COVID-19 Pandemic on the Psychological Well-Being of Caregivers of People with Dementia or Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.", "authors": [{"family": "Soysal", "given": "Pinar", "initials": "P", "orcid": "0000-0002-6042-1718", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9532f14058b74f4ba9ef9a91363ef928.json"}}, {"family": "Veronese", "given": "Nicola", "initials": "N", "orcid": "0000-0002-9328-289X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a2cc37554334aa09c617b388c653fd6.json"}}, {"family": "Smith", "given": "Lee", "initials": "L", "orcid": "0000-0002-5340-9833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4a80139dc424c4a83615832dfdff7fc.json"}}, {"family": "Chen", "given": "Yaohua", "initials": "Y", "orcid": "0000-0003-1778-1790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b457f904786486499affe9db4fd9610.json"}}, {"family": "Akpinar Soylemez", "given": "Burcu", "initials": "B"}, {"family": "Coin", "given": "Alessandra", "initials": "A"}, {"family": "Religa", "given": "Dorota", "initials": "D", "orcid": "0000-0003-4583-4570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e2c968ecffa4c638126d6d8d4a0dbd9.json"}}, {"family": "V\u00e4lim\u00e4ki", "given": "Tarja", "initials": "T", "orcid": "0000-0001-6178-5671", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1d17a5f5f124cf1b87188ef357e78a9.json"}}, {"family": "Alves", "given": "Mariana", "initials": "M"}, {"family": "Shenkin", "given": "Susan D", "initials": "SD", "orcid": "0000-0001-7375-4776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/939e65f9dcda409796466872995bdbd1.json"}}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "Geriatrics (Basel)", "issn": "2308-3417", "issn-l": null, "volume": "8", "issue": "5", "pages": null}, "abstract": "The aim of this systematic review was to investigate the effects of the COVID-19 lockdown on the psychological well-being of caregivers of people with dementia or mild cognitive impairment (PwD/MCI). Electronic databases were searched from inception to August 2022 for observational studies investigating the COVID-19 lockdown and psychological well-being of caregivers of PwD/MCI. Summary estimates of standardized mean differences (SMD) in psychological well-being scores pre- versus during COVID-19 were calculated using a random-effects model. Fifteen studies including 1702 caregivers (65.7% female, mean age 60.40 \u00b1 12.9 years) with PwD/MCI were evaluated. Five studies found no change in psychological well-being parameters, including depression, anxiety, distress, caregiver burden, and quality of life. Ten studies found a worsening in at least one parameter: depression (six studies, n = 1368; SMD = 0.40; 95%CI: 0.09-0.71; p = 0.01, I2 = 86.8%), anxiety (seven studies, n = 1569; SMD = 1.35; 95%CI: 0.05-2.65; I2 = 99.2%), caregiver distress (six studies, n = 1320, SMD = 3.190; 95%CI: 1.42-4.95; p < 0.0001; I2 = 99.4%), and caregiver burden (four studies, n = 852, SMD = 0.34; 95%CI: 0.13-0.56; p = 0.001; I2 = 54.1%) (p < 0.05). There was an increase in depression, anxiety, caregiver burden, and distress in caregivers of PwD/MCI during the lockdown in the COVID pandemic. This could have longer term consequences, and it is essential that caregivers' psychological well-being is assessed and supported, to benefit both themselves and those for whom they care.", "doi": "10.3390/geriatrics8050097", "pmid": "37887970", "labels": {"Type: Review": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10606547"}, {"db": "pii", "key": "geriatrics8050097"}], "notes": [], "created": "2023-11-02T07:26:36.865Z", "modified": "2023-11-02T07:27:19.520Z"}, {"entity": "publication", "iuid": "2102e5f0fcb94665b9e6809fb4fb6148", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2102e5f0fcb94665b9e6809fb4fb6148.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2102e5f0fcb94665b9e6809fb4fb6148"}}, "title": "Reproducibility in pharmacometrics applied in a phase III trial of BCG-vaccination for COVID-19.", "authors": [{"family": "van Wijk", "given": "Rob C", "initials": "RC", "orcid": "0000-0001-7247-1360", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aac8bd1a2d674d6c891c1a0becf997d8.json"}}, {"family": "Mockeliunas", "given": "Laurynas", "initials": "L"}, {"family": "van den Hoogen", "given": "Gerben", "initials": "G"}, {"family": "Upton", "given": "Caryn M", "initials": "CM", "orcid": "0000-0002-7503-3320", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/518562f81f0340acaeb7f202bb01403a.json"}}, {"family": "Diacon", "given": "Andreas H", "initials": "AH"}, {"family": "Simonsson", "given": "Ulrika S H", "initials": "USH", "orcid": "0000-0002-3424-9686", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf510f552f2846b5bbb7740872a7c24a.json"}}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "16292"}, "abstract": "Large clinical trials often generate complex and large datasets which need to be presented frequently throughout the trial for interim analysis or to inform a data safety monitory board (DSMB). In addition, reliable and traceability are required to ensure reproducibility in pharmacometric data analysis. A reproducible pharmacometric analysis workflow was developed during a large clinical trial involving 1000 participants over one year testing Bacillus Calmette-Gu\u00e9rin (BCG) (re)vaccination in coronavirus disease 2019 (COVID-19) morbidity and mortality in frontline health care workers. The workflow was designed to review data iteratively during the trial, compile frequent reports to the DSMB, and prepare for rapid pharmacometric analysis. Clinical trial datasets (n = 41) were transferred iteratively throughout the trial for review. An RMarkdown based pharmacometric processing script was written to automatically generate reports for evaluation by the DSMB. Reports were compiled, reviewed, and sent to the DSMB on average three days after the data cut-off, reflecting the trial progress in real-time. The script was also utilized to prepare for the trial pharmacometric analyses. The same source data was used to create analysis datasets in NONMEM format and to support model script development. The primary endpoint analysis was completed three days after data lock and unblinding, and the secondary endpoint analyses two weeks later. The constructive collaboration between clinical, data management, and pharmacometric teams enabled this efficient, timely, and reproducible pharmacometrics workflow.", "doi": "10.1038/s41598-023-43412-3", "pmid": "37770596", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10539503"}, {"db": "pii", "key": "10.1038/s41598-023-43412-3"}], "notes": [], "created": "2023-10-06T06:57:15.951Z", "modified": "2023-10-06T11:40:12.550Z"}, {"entity": "publication", "iuid": "17149842d47b4a09bb7a58f9d9341fb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/17149842d47b4a09bb7a58f9d9341fb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/17149842d47b4a09bb7a58f9d9341fb1"}}, "title": "Neurofilament light chain on intensive care admission is an independent predictor of mortality in COVID-19: a prospective multicenter study.", "authors": [{"family": "Sievert", "given": "Theodor", "initials": "T", "orcid": "0009-0009-9630-2540", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a8d175437a84f5c863058f2207ca332.json"}}, {"family": "Didriksson", "given": "Ingrid", "initials": "I"}, {"family": "Sp\u00e5ngfors", "given": "Martin", "initials": "M"}, {"family": "Lilja", "given": "Gisela", "initials": "G"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Frigyesi", "given": "Attila", "initials": "A"}, {"family": "Friberg", "given": "Hans", "initials": "H"}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "Intensive Care Med Exp", "issn": "2197-425X", "issn-l": null, "volume": "11", "issue": "1", "pages": "66"}, "abstract": "Neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and total-tau protein (tau) are novel blood biomarkers of neurological injury, and may be used to predict outcomes in critical COVID-19.\r\n\r\nA prospective multicentre cohort study of 117 consecutive and critically ill COVID-19 patients in six intensive care units (ICUs) in southern Sweden between May and November 2020. Serial NfL, GFAP and tau were analysed in relation to mortality, the Glasgow Outcome Scale Extended (GOSE) and the physical (PCS) and mental (MCS) components of health-related quality of life at one year.\r\n\r\nNfL, GFAP and tau on ICU admission predicted one-year mortality with an area under the curve (AUC) of 0.82 (95% confidence interval [CI] 0.74[Formula: see text]0.90), 0.72 (95% CI 0.62[Formula: see text]0.82) and 0.66 (95% CI 0.54[Formula: see text]0.77). NfL on admission was an independent predictor of one-year mortality (p = 0.039). Low NfL and GFAP values were associated with good PCS ([Formula: see text]45) at one year but not with good MCS ([Formula: see text]45) or GOSE ([Formula: see text]5).\r\n\r\nNfL on ICU admission was an independent predictor of mortality. High levels of NfL, GFAP and tau were associated with mortality but not with poor GOSE in survivors at one year. Low levels of NfL and GFAP were associated with improved physical health-related quality of life.", "doi": "10.1186/s40635-023-00547-x", "pmid": "37768470", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null, "Category: Public Health": null, "Funder: H2020": null}, "xrefs": [{"db": "pmc", "key": "PMC10539241"}, {"db": "pii", "key": "10.1186/s40635-023-00547-x"}], "notes": [], "created": "2023-10-06T06:56:44.290Z", "modified": "2023-10-06T11:27:36.202Z"}, {"entity": "publication", "iuid": "49150db4defd486aae6259e7cdee919d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49150db4defd486aae6259e7cdee919d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49150db4defd486aae6259e7cdee919d"}}, "title": "Increased intra-pulmonary shunt and alveolar dead space post COVID-19.", "authors": [{"family": "Farrow", "given": "Catherine E", "initials": "CE"}, {"family": "Robles", "given": "Robert", "initials": "R"}, {"family": "Prisk", "given": "G Kim", "initials": "GK"}, {"family": "Harbut", "given": "Piotr", "initials": "P"}, {"family": "Malhotra", "given": "Atul", "initials": "A"}, {"family": "Amis", "given": "Terence C", "initials": "TC"}, {"family": "Wagner", "given": "Peter D", "initials": "PD"}, {"family": "Kairaitis", "given": "Kristina", "initials": "K"}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "J Appl Physiol (1985)", "issn": "1522-1601", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Increased intrapulmonary shunt(QS/Qt) and alveolar dead space(VD/VT) are present in early recovery from COVID-19. We hypothesized patients recovering from severe-critical acute illness(NIH category 3-5) would have greater and longer-lasting increased QS/Qt and VD/VT than patients with mild-moderate acute illness(NIH 1-2).\r\n\r\n59 unvaccinated patients (33 male, age 52[38-61] years, BMI 28.8[25.3-33.6] kg/m2; median[IQR], 44 previous mild-moderate COVID-19, and 15 severe-critical disease), were studied 15-403 days post-acute SARS-CoV-2 infection. Breathing ambient air, steady-state mean alveolar PCO2 and PO2 were recorded simultaneously with arterial PO2/PCO2 yielding aAPCO2, AaPO2, and from these, QS/Qt%, VD/VT%, and relative alveolar ventilation (40 mmHg/PACO2, VArel) calculated.\r\n\r\nMedian PaCO2 was 39.4[35.6-41.1] mmHg, PaO2 92.3[87.1-98.2mmHg; PACO2 32.8[28.6-35.3] mmHg, PAO2 112.9[109.4-117.0] mmHg, AaPO2 18.8[12.6-26.8] mmHg, aAPCO2 5.9 [4.3-8.0] mmHg, QS/Qt 4.3 [2.1-5.9] % and VD/VT16.6 [12.6-24.4] %. Only 14% of patients had normal QS/Qt and VD/VT;1% increased QS/Qt but normal VD/VT; 49% normal QS/Qt and elevated VD/VT;36% both abnormal QS/Qtand VD/VT. Previous severe-critical COVID-19 predicted increased QS/Qt (2.69 [0.82-4.57]% per category severity [95% CI], p<0.01), but not VD/VT. Increasing age weakly predicted increased VD/VT (1.6 [0.1-3.2]% per decade, p<0.04). Time since infection, BMI and comorbidities were not predictors (all p > 0.11). VArel was increased in most patients.\r\n\r\nIn our population, recovery from COVID-19 was associated with increased QS/Qt in 37% of patients, increased VD/VT in 86%, and increased alveolar ventilation up to ~13 months post infection. NIH severity predicted QS/Qt but not elevated VD/VT. Increased VD/VT suggests pulmonary micro-vascular pathology persists post COVID-19 in most patients.", "doi": "10.1152/japplphysiol.00267.2023", "pmid": "37767555", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:56:06.924Z", "modified": "2023-10-06T11:05:04.600Z"}, {"entity": "publication", "iuid": "8a71d2ffb92044e7b93c1c9be9dd275c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a71d2ffb92044e7b93c1c9be9dd275c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a71d2ffb92044e7b93c1c9be9dd275c"}}, "title": "Impact of COVID-19 in Patients with Heart Failure with Mildly Reduced or Preserved Ejection Fraction Enrolled in the DELIVER Trial.", "authors": [{"family": "Bhatt", "given": "Ankeet S", "initials": "AS"}, {"family": "Kosiborod", "given": "Mikhail N", "initials": "MN"}, {"family": "Claggett", "given": "Brian L", "initials": "BL"}, {"family": "Miao", "given": "Zi Michael", "initials": "ZM"}, {"family": "Vaduganathan", "given": "Muthiah", "initials": "M"}, {"family": "Lam", "given": "Carolyn S P", "initials": "CSP"}, {"family": "Hernandez", "given": "Adrian F", "initials": "AF"}, {"family": "Martinez", "given": "Felipe A", "initials": "FA"}, {"family": "Inzucchi", "given": "Silvio E", "initials": "SE"}, {"family": "Shah", "given": "Sanjiv J", "initials": "SJ"}, {"family": "de Boer", "given": "Rudolf A", "initials": "RA"}, {"family": "Jhund", "given": "Pardeep S", "initials": "PS"}, {"family": "Desai", "given": "Akshay S", "initials": "AS"}, {"family": "Fang", "given": "James C", "initials": "JC"}, {"family": "Han", "given": "Yaling", "initials": "Y"}, {"family": "Comin-Colet", "given": "Josep", "initials": "J"}, {"family": "Dro\u017cd\u017c", "given": "Jaros\u0142aw", "initials": "J"}, {"family": "Vardeny", "given": "Orly", "initials": "O"}, {"family": "Merkely", "given": "Bela", "initials": "B"}, {"family": "Lindholm", "given": "Daniel", "initials": "D"}, {"family": "Peterson", "given": "Magnus", "initials": "M"}, {"family": "Langkilde", "given": "Anna Maria", "initials": "AM"}, {"family": "McMurray", "given": "John J V", "initials": "JJV"}, {"family": "Solomon", "given": "Scott D", "initials": "SD"}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "Eur J Heart Fail", "issn": "1879-0844", "issn-l": "1388-9842", "volume": null, "issue": null, "pages": null}, "abstract": "COVID-19 may affect clinical risk in patients with heart failure. DELIVER began before and was conducted during the COVID-19 pandemic.\r\n\r\nWe evaluated the association between COVID-19 and outcomes among DELIVER participants.\r\n\r\nParticipants with chronic HFmrEF/HFpEF were randomized to dapagliflozin or placebo across 350 sites in 20 countries. COVID-19 was investigator-reported and the contribution of COVID-19 to death was centrally adjudicated. We assessed (1) incidence of COVID-19, (2) event rates before/during the pandemic, and (3) risks of death after diagnosis compared to death in participants without COVID-19. Further, we performed a sensitivity analysis assessing treatment effects censored at pandemic onset.\r\n\r\nOf 6263 participants, 589 (9.4%) developed COVID-19, of whom 307 (52%) required/prolonged hospitalization. 155 deaths (15% of all deaths) were adjudicated as definitely/possibly COVID-19 related. COVID-19 cases and deaths did not differ by randomized assignment. Death-rate in the 12-months following diagnosis was 56.1 (95% CI:48.0 to 65.6) vs. 6.4 (95% CI:6.0-6.8)/100-participant-years among trial participants with versus without COVID-19 (aHR:8.60,95% CI:7.18-10.30). Risk was highest 0-3 months following diagnosis (153.5,95% CI:130.3-180.8) and remained elevated at 3-6 months (12.6,95% CI:6.6-24.3/100-participant-years). After excluding investigator reported fatal COVID-19 events, all-cause death rates in the 12 months following diagnosis among COVID-19 survivors (n = 458) remained higher (aHR: 2.46, 95% CI: 1.83 to 3.33) than all trial participants from randomization, with censoring of participants who developed COVID-19 at the time of diagnosis. Dapagliflozin reduced the CV death/worsening HF events when censoring participants at COVID-19 diagnosis (HR:0.81,95%CI:0.72-0.91) and pandemic onset (HR:0.72,95%CI:0.58-0.89). There were no DKA or major hypoglycemic events within 30-days of COVID-19.\r\n\r\nDELIVER is one of the most extensive experiences with COVID-19 of any cardiovascular trial, with >75% of follow-up time occurring during the pandemic. COVID-19 was common, with >50% of cases leading to hospitalization or death. Treatment benefits of dapagliflozin persisted when censoring at COVID-19 diagnosis and pandemic onset. Patients surviving COVID-19 event had a high early residual risk. This article is protected by copyright. All rights reserved.", "doi": "10.1002/ejhf.3043", "pmid": "37771274", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:55:17.131Z", "modified": "2023-10-06T10:49:36.886Z"}, {"entity": "publication", "iuid": "ffccce5c119444b6a27350ba05693be3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ffccce5c119444b6a27350ba05693be3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ffccce5c119444b6a27350ba05693be3"}}, "title": "Gender differences in patient experience in idiopathic inflammatory myopathies: Sub analysis from the COVAD dataset.", "authors": [{"family": "Yoshida", "given": "Akira", "initials": "A", "orcid": "0000-0003-3590-1637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e26dfbeb7e8486a8492abc2700590df.json"}}, {"family": "Kim", "given": "Minchul", "initials": "M"}, {"family": "Kuwana", "given": "Masataka", "initials": "M"}, {"family": "Ravichandran", "given": "Naveen", "initials": "N"}, {"family": "Makol", "given": "Ashima", "initials": "A"}, {"family": "Sen", "given": "Parikshit", "initials": "P"}, {"family": "Lilleker", "given": "James B", "initials": "JB"}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V"}, {"family": "Kardes", "given": "Sinan", "initials": "S"}, {"family": "Day", "given": "Jessica", "initials": "J"}, {"family": "Milchert", "given": "Marcin", "initials": "M"}, {"family": "Joshi", "given": "Mrudula", "initials": "M"}, {"family": "Gheita", "given": "Tamer", "initials": "T"}, {"family": "Salim", "given": "Babur", "initials": "B"}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T"}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE"}, {"family": "Parodis", "given": "Ioannis", "initials": "I"}, {"family": "Nikiphorou", "given": "Elena", "initials": "E"}, {"family": "Chatterjee", "given": "Tulika", "initials": "T"}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL"}, {"family": "Nune", "given": "Arvind", "initials": "A"}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L"}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA"}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK"}, {"family": "Ziade", "given": "Nelly", "initials": "N"}, {"family": "Knitza", "given": "Johannes", "initials": "J"}, {"family": "Distler", "given": "Oliver", "initials": "O"}, {"family": "Chinoy", "given": "Hector", "initials": "H"}, {"family": "Agarwal", "given": "Vikas", "initials": "V"}, {"family": "Aggarwal", "given": "Rohit", "initials": "R"}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "Mod Rheumatol", "issn": "1439-7609", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "We aimed to investigate gender-based differences in idiopathic inflammatory myopathies (IIMs), with a particular focus on patient-reported outcomes, utilizing data obtained through the international COVID-19 vaccination in autoimmune disease (COVAD) e-survey.\r\n\r\nPatient-reported outcomes including fatigue, pain, and physical function were extracted from the COVAD database and compared between genders, adjusting for demographics and IIM subgroups by multivariable analysis. Inclusion body myositis (IBM) was analysed separately because of substantial differences in outcomes.\r\n\r\n1197 complete responses from patients with IIMs as of 31 August 2021 were analysed. Seventy percent were women. Women were younger (58 [48-68] vs. 69 [58-75] years old, median [IQR], p < 0.001) and more likely to suffer from autoimmune multimorbidity, defined as three or more autoimmune diseases in an individual patient (11.4% vs. 2.8%, p < 0.001). In non-IBM IIMs, fatigue visual analogue scale scores were higher in women (5 [3-7] vs. 4 [2-6], median [IQR], p = 0.004), whereas no significant gender-based differences were noted in IBM. Multivariable analysis in non-IBM IIMs revealed women, residence in high-income countries, overlap myositis, and autoimmune multimorbidity were independently associated with increased fatigue.\r\n\r\nWomen with IIMs suffer from autoimmune multimorbidity and experience increased fatigue compared to men.", "doi": "10.1093/mr/road094", "pmid": "37769200", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "7285588"}], "notes": [], "created": "2023-10-06T06:57:42.055Z", "modified": "2023-10-06T11:47:26.839Z"}, {"entity": "publication", "iuid": "16e8a5f9090f4d7c933c8cfd4386eda0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16e8a5f9090f4d7c933c8cfd4386eda0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16e8a5f9090f4d7c933c8cfd4386eda0"}}, "title": "Evaluation of a human mucosal tissue explant model for SARS-CoV-2 replication.", "authors": [{"family": "Gordhan", "given": "Bhavna Gowan", "initials": "BG"}, {"family": "Herrera", "given": "Carolina", "initials": "C"}, {"family": "Pillay", "given": "Azure-Dee", "initials": "A"}, {"family": "Seiphetlo", "given": "Thabiso", "initials": "T"}, {"family": "Ealand", "given": "Christopher Shawn", "initials": "CS"}, {"family": "Machowski", "given": "Edith", "initials": "E"}, {"family": "Singh", "given": "Natasha", "initials": "N"}, {"family": "Seatholo", "given": "Ntombexolo", "initials": "N"}, {"family": "Otwombe", "given": "Kennedy", "initials": "K"}, {"family": "Lebina", "given": "Limakatso", "initials": "L"}, {"family": "Frise", "given": "Rebecca", "initials": "R"}, {"family": "Scarlatti", "given": "Gabriella", "initials": "G"}, {"family": "Chiodi", "given": "Francesca", "initials": "F"}, {"family": "Martinson", "given": "Neil", "initials": "N"}, {"family": "Fox", "given": "Julie", "initials": "J"}, {"family": "Kana", "given": "Bavesh Davandra", "initials": "BD", "orcid": "0000-0001-9713-3480", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/444ca8b6b7e444f1a55ddab2e87c5f2d.json"}}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "9", "pages": "e0291146"}, "abstract": "With the onset of COVID-19, the development of ex vivo laboratory models became an urgent priority to study host-pathogen interactions in response to the pandemic. In this study, we aimed to establish an ex vivo mucosal tissue explant challenge model for studying SARS-CoV-2 infection and replication. Nasal or oral tissue samples were collected from eligible participants and explants generated from the tissue were infected with various SARS-CoV-2 strains, including IC19 (lineage B.1.13), Beta (lineage B.1.351) and Delta (lineage B.1.617.2). A qRT-PCR assay used to measure viral replication in the tissue explants over a 15-day period, demonstrated no replication for any viral strains tested. Based on this, the ex vivo challenge protocol was modified by reducing the viral infection time and duration of sampling. Despite these changes, viral infectivity of the nasal and oral mucosa was not improved. Since 67% of the enrolled participants were already vaccinated against SARS-CoV-2, it is possible that neutralizing antibodies in explant tissue may have prevented the establishment of infection. However, we were unable to optimize plaque assays aimed at titrating the virus in supernatants from both infected and uninfected tissue, due to limited volume of culture supernatant available at the various collection time points. Currently, the reasons for the inability of these mucosal tissue samples to support replication of SARS-CoV-2 ex vivo remains unclear and requires further investigation.", "doi": "10.1371/journal.pone.0291146", "pmid": "37769001", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Other": null, "Category: Genomics & transcriptomics": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC10538748"}, {"db": "pii", "key": "PONE-D-23-15626"}], "notes": [], "created": "2023-10-06T06:52:46.172Z", "modified": "2023-10-06T12:03:46.988Z"}, {"entity": "publication", "iuid": "beb69223dbf744a6a67c81eddf7d1f94", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/beb69223dbf744a6a67c81eddf7d1f94.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/beb69223dbf744a6a67c81eddf7d1f94"}}, "title": "Endotheliitis and cytokine storm as a mechanism of clot formation in COVID-19 ischemic stroke patients: A histopathologic study of retrieved clots.", "authors": [{"family": "Brinjikji", "given": "Waleed", "initials": "W"}, {"family": "Kallmes", "given": "David F", "initials": "DF", "orcid": "0000-0002-8495-0040", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3afdb017a42249bfb13d88ef55c0b77c.json"}}, {"family": "Virmani", "given": "Renu", "initials": "R"}, {"family": "de Meyer", "given": "Simon F", "initials": "SF"}, {"family": "Yoo", "given": "Albert J", "initials": "AJ"}, {"family": "Humphries", "given": "William", "initials": "W"}, {"family": "Zaidat", "given": "Osama O", "initials": "OO"}, {"family": "Teleb", "given": "Mohamed S", "initials": "MS"}, {"family": "Jones", "given": "Jesse G", "initials": "JG", "orcid": "0000-0002-2682-9736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8b2eb443d9242339db2c60ff1e2ff61.json"}}, {"family": "Siddiqui", "given": "Adnan H", "initials": "AH"}, {"family": "Andersson", "given": "Tommy", "initials": "T"}, {"family": "Nogueira", "given": "Raul G", "initials": "RG"}, {"family": "Gil", "given": "Sara Molina", "initials": "SM"}, {"family": "Douglas", "given": "Andrew", "initials": "A"}, {"family": "Rossi", "given": "Rosanna", "initials": "R", "orcid": "0000-0002-3656-2908", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e94c727f4e504aec82996f36a18c4800.json"}}, {"family": "Rentzos", "given": "Alexander", "initials": "A"}, {"family": "Ceder", "given": "Erik", "initials": "E"}, {"family": "Carlqvist", "given": "Jeanette", "initials": "J"}, {"family": "Dunker", "given": "Dennis", "initials": "D"}, {"family": "Jood", "given": "Katarina", "initials": "K"}, {"family": "Tatlisumak", "given": "Turgut", "initials": "T"}, {"family": "Doyle", "given": "Karen M", "initials": "KM", "orcid": "0000-0001-8984-6296", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a3c861faf81495a97e1e85ea3f8dd88.json"}}], "type": "journal article", "published": "2023-09-28", "journal": {"title": "Interv Neuroradiol", "issn": "2385-2011", "issn-l": null, "volume": null, "issue": null, "pages": "15910199231185804"}, "abstract": "Studies during the COVID-19 pandemic have demonstrated an association between COVID-19 virus infection and the development of acute ischemic stroke, particularly large vessel occlusion (LVO). Studying the characteristics and immunohistochemistry of retrieved stroke emboli during mechanical thrombectomy for LVO may offer insights into the pathogenesis of LVO in COVID-19 patients. We examined retrieved COVID-19 emboli from the STRIP, EXCELLENT, and RESTORE registries and compared their characteristics to a control group.\r\n\r\nWe identified COVID-positive LVO patients from the STRIP, RESTORE, and EXCELLENT studies who underwent mechanical thrombectomy. These patients were matched to a control group controlling for stroke etiology based on Trial of Org 10172 in Acute Stroke Treatment criteria. All clots were stained with Martius Scarlet Blue (MSB) along with immunohistochemistry for interleukin-6 (IL-6), C-reactive protein (CRP), von Willebrand factor (vWF), CD66b, fibrinogen, and citrullinated Histone H3. Clot composition was compared between groups.\r\n\r\nNineteen COVID-19-positive patients and 38 controls were included. COVID-19-positive patients had a significantly higher percentage of CRP and vWF. There was no difference in IL-6, fibrin, CD66b, or citrullinated Histone H3 between groups. Based on MSB staining, there was no statistically significant difference regarding the percentage of red blood cells, white blood cells, fibrin, and platelets.\r\n\r\nOur study found higher concentrations of CRP and vWF in retrieved clots of COVID-19-positive stroke patients compared to COVID-19-negative controls. These findings support the potential role of systemic inflammation as indicated by elevated CRP and endothelial injury as indicated by elevated vWF as precipitating factors in thrombus development in these patients.", "doi": "10.1177/15910199231185804", "pmid": "37769315", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:55:14.627Z", "modified": "2023-10-06T10:48:05.804Z"}, {"entity": "publication", "iuid": "d5d748c6457d43149e8ec2a7fe6063af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5d748c6457d43149e8ec2a7fe6063af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5d748c6457d43149e8ec2a7fe6063af"}}, "title": "Prior physical illness predicts death better than acute physiological derangement on intensive care unit admission in COVID-19: A Swedish registry study.", "authors": [{"family": "Stattin", "given": "Karl", "initials": "K", "orcid": "0000-0003-1537-6740", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/249d788a7d1f4088aca67f8265561b9b.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Kawati", "given": "Rafael", "initials": "R"}], "type": "journal article", "published": "2023-09-27", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "9", "pages": "e0292186"}, "abstract": "COVID-19 is associated with prolonged intensive care unit (ICU) stay and considerable mortality. The onset of persistent critical illness, defined as when prior illness predicts death better than acute physiological derangement, has not been studied in COVID-19. This national cohort study based on the Swedish Intensive Care Registry (SIR) included all patients admitted to a Swedish ICU due to COVID-19 from 6 March 2020 to 9 November 2021. Simplified Acute Physiology Score-3 (SAPS3) Box 1 was used as a measure of prior illness and Box 3 as a measure of acute derangement to evaluate the onset and importance of persistent critical illness in COVID-19. To compare predictive capacity, the area under receiver operating characteristic (AUC) of SAPS3 and its constituent Box 1 and 3 was calculated for 30-day mortality. In 7 969 patients, of which 1 878 (23.6%) died within 30 days of ICU admission, the complete SAPS3 score had acceptable discrimination: AUC 0.75 (95% CI 0.74 to 0.76) but showed under prediction in low-risk patients and over prediction in high-risk patients. SAPS3 Box 1 showed markedly better discrimination than Box 3 (AUC 0.74 vs 0.65, P<0,0001). Using custom logistic models, the difference in predictive performance of prior and acute illness was validated, AUC 0.76 vs AUC 0.69, p<0.0001. Prior physical illness predicts death in COVID-19 better than acute physiological derangement during ICU stay, and the whole SAPS3 score is not significantly better than just prior illness. The results suggests that COVID-19 may exhibit similarities to persistent critical illness immediately from ICU admission, potentially because of long median ICU length-of-stay. Alternatively, the variables in the acute physiological derangement model may not adequately capture the severity of illness in COVID-19.", "doi": "10.1371/journal.pone.0292186", "pmid": "37756328", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Public Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: KAW/SciLifeLab": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC10529545"}, {"db": "pii", "key": "PONE-D-23-04974"}], "notes": [], "created": "2023-10-06T06:52:56.012Z", "modified": "2023-10-06T09:59:42.196Z"}, {"entity": "publication", "iuid": "6c3a64fd6fff4dcaa6aa9206c19e2fba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c3a64fd6fff4dcaa6aa9206c19e2fba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c3a64fd6fff4dcaa6aa9206c19e2fba"}}, "title": "Prevalence of SARS-CoV-2 Omicron Sublineages and Spike Protein Mutations Conferring Resistance against Monoclonal Antibodies in a Swedish Cohort during 2022-2023.", "authors": [{"family": "Haars", "given": "Jonathan", "initials": "J", "orcid": "0009-0003-8735-4097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ac6ff5ce97541b9823d1c9204366e56.json"}}, {"family": "Palanisamy", "given": "Navaneethan", "initials": "N", "orcid": "0000-0003-0369-2316", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e92f0f2edcb4c8eaa66f55c59490717.json"}}, {"family": "Wallin", "given": "Frans", "initials": "F"}, {"family": "M\u00f6lling", "given": "Paula", "initials": "P"}, {"family": "Lindh", "given": "Johan", "initials": "J"}, {"family": "Sundqvist", "given": "Martin", "initials": "M"}, {"family": "Ellstr\u00f6m", "given": "Patrik", "initials": "P"}, {"family": "Kaden", "given": "Ren\u00e9", "initials": "R", "orcid": "0000-0002-2111-9751", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2be6374ef0bf4ba39e5f5dbbb059747f.json"}}, {"family": "Lennerstrand", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2023-09-27", "journal": {"title": "Microorganisms", "issn": "2076-2607", "issn-l": "2076-2607", "volume": "11", "issue": "10", "pages": null}, "abstract": "Monoclonal antibodies (mAbs) are an important treatment option for COVID-19 caused by SARS-CoV-2, especially in immunosuppressed patients. However, this treatment option can become ineffective due to mutations in the SARS-CoV-2 genome, mainly in the receptor binding domain (RBD) of the spike (S) protein. In the present study, 7950 SARS-CoV-2 positive samples from the Uppsala and \u00d6rebro regions of central Sweden, collected between March 2022 and May 2023, were whole-genome sequenced using amplicon-based sequencing methods on Oxford Nanopore GridION, Illumina MiSeq, Illumina HiSeq, or MGI DNBSEQ-G400 instruments. Pango lineages were determined and all single nucleotide polymorphism (SNP) mutations that occurred in these samples were identified. We found that the dominant sublineages changed over time, and mutations conferring resistance to currently available mAbs became common. Notable ones are R346T and K444T mutations in the RBD that confer significant resistance against tixagevimab and cilgavimab mAbs. Further, mutations conferring a high-fold resistance to bebtelovimab, such as the K444T and V445P mutations, were also observed in the samples. This study highlights that resistance mutations have over time rendered currently available mAbs ineffective against SARS-CoV-2 in most patients. Therefore, there is a need for continued surveillance of resistance mutations and the development of new mAbs that target more conserved regions of the RBD.", "doi": "10.3390/microorganisms11102417", "pmid": "37894075", "labels": {"Category: Proteins": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10609123"}, {"db": "pii", "key": "microorganisms11102417"}], "notes": [], "created": "2023-11-01T13:31:56.850Z", "modified": "2023-11-01T13:51:18.963Z"}, {"entity": "publication", "iuid": "53b88ea1a9294cf6940e0dc6bb00c61f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53b88ea1a9294cf6940e0dc6bb00c61f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53b88ea1a9294cf6940e0dc6bb00c61f"}}, "title": "Health Care Personnel's Perspectives on Quality of Palliative Care During the COVID-19 Pandemic - A Cross-Sectional Study.", "authors": [{"family": "Granrud", "given": "Marie Dahlen", "initials": "MD"}, {"family": "Gr\u00f8ndahl", "given": "Vigdis Abrahamsen", "initials": "VA", "orcid": "0000-0002-8296-7682", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c34c6c8599e4466af1a3830060dd660.json"}}, {"family": "Helgesen", "given": "Ann Karin", "initials": "AK", "orcid": "0000-0003-4572-9439", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/673ff54d4a6347dfa0b8bb21481e5a8c.json"}}, {"family": "B\u00e5\u00e5th", "given": "Carina", "initials": "C", "orcid": "0000-0002-9608-336X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05b8f4fac40b4da7a00e69b8451cb25b.json"}}, {"family": "Olsson", "given": "Cecilia", "initials": "C"}, {"family": "Tillfors", "given": "Maria", "initials": "M"}, {"family": "Melin-Johansson", "given": "Christina", "initials": "C"}, {"family": "\u00d6sterlind", "given": "Jane", "initials": "J"}, {"family": "Larsson", "given": "Maria", "initials": "M"}, {"family": "Hov", "given": "Reidun", "initials": "R"}, {"family": "Sandsdalen", "given": "Tuva", "initials": "T", "orcid": "0000-0002-6699-8059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6302338a98b0435b988f28517d845fd5.json"}}], "type": "journal article", "published": "2023-09-27", "journal": {"title": "J Multidiscip Healthc", "issn": "1178-2390", "issn-l": null, "volume": "16", "issue": null, "pages": "2893-2903"}, "abstract": "The provision of high-quality palliative care is challenging, especially during a pandemic like COVID-19. The latter entailed major consequences for health care systems and health care personnel (HCP) in both specialist and community health care services, in Norway and worldwide. The aim of this study was to explore how the HCP perceived the quality of palliative care in nursing homes, medical care units, and intensive care units during the COVID-19 pandemic.\r\n\r\nThis study had a cross-sectional design. A total of 290 HCP from Norway participated in the study (RR = 25.8%) between October and December 2021. The questionnaire comprised items concerning respondents' demographics and quality of care, the latter measured by the short form of the Quality from the Patient's Perspective-Palliative Care instrument, adapted for HCP. The STROBE checklist was used.\r\n\r\nThis study shows that the HCP scored subjective importance as higher in all dimensions, items and single items than their perception of the actual care received. This could indicate a need for improvement in all areas. Information about medication, opportunity to participate in decisions about medical and nursing care and continuity regarding receiving help from the same physician and nurse are examples of areas for improvement.\r\n\r\nStudy results indicate that HCP from nursing homes, medical care units, and intensive care units perceived that quality of palliative care provided was not in line with what they perceived to be important for the patient. This indicate that it was challenging to provide high-quality palliative care during the COVID-19 pandemic.", "doi": "10.2147/JMDH.S419442", "pmid": "37790989", "labels": {"Category: Social Science & Humanities": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10543989"}, {"db": "pii", "key": "419442"}], "notes": [], "created": "2023-11-01T13:33:07.426Z", "modified": "2023-11-02T07:12:31.702Z"}, {"entity": "publication", "iuid": "e318b799f41c458f80c14568469c767f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e318b799f41c458f80c14568469c767f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e318b799f41c458f80c14568469c767f"}}, "title": "Cognitive dysfunction in post-COVID-19 condition: Mechanisms, management, and rehabilitation.", "authors": [{"family": "M\u00f6ller", "given": "Marika", "initials": "M"}, {"family": "Borg", "given": "Kristian", "initials": "K"}, {"family": "Janson", "given": "Christer", "initials": "C"}, {"family": "Lerm", "given": "Maria", "initials": "M"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Niward", "given": "Katarina", "initials": "K"}], "type": "journal article", "published": "2023-09-27", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The long-term effects of COVID-19 on cognitive function have become an area of increasing concern. This paper provides an overview of characteristics, risk factors, possible mechanisms, and management strategies for cognitive dysfunction in post-COVID-19 condition (PCC). Prolonged cognitive dysfunction is one of the most common impairments in PCC, affecting between 17% and 28% of the individuals more than 12 weeks after the infection and persisting in some cases for several years. Cognitive dysfunctions can be manifested as a wide range of symptoms including memory impairment, attention deficit, executive dysfunction, and reduced processing speed. Risk factors for developing PCC, with or without cognitive impairments, include advanced age, preexisting medical conditions, and the severity of acute illness. The underlying mechanisms remain unclear, but proposed contributors include neuroinflammation, hypoxia, vascular damage, and latent virus reactivation not excluding the possibility of direct viral invasion of the central nervous system, illustrating complex viral pathology. As the individual variation of the cognitive impairments is large, a neuropsychological examination and a person-centered multidimensional approach are required. According to the World Health Organization, limited evidence on COVID-19-related cognitive impairments necessitates implementing rehabilitation interventions from established practices of similar conditions. Psychoeducation and compensatory skills training are recommended. Assistive products and environmental modifications adapted to individual needs might be helpful. In specific attention- and working memory dysfunctions, cognitive training-carefully monitored for intensity-might be effective for people who do not suffer from post-exertional malaise. Further research is crucial for evidence-based interventions specific to COVID-19-related cognitive impairments.", "doi": "10.1111/joim.13720", "pmid": "37766515", "labels": {"Category: Rehabilitation": null, "Category: Post-COVID": null, "Type: Review": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:55:23.836Z", "modified": "2023-10-06T10:52:52.998Z"}, {"entity": "publication", "iuid": "e1e6f31128384d6aab68ccc445739304", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e1e6f31128384d6aab68ccc445739304.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e1e6f31128384d6aab68ccc445739304"}}, "title": "SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood.", "authors": [{"family": "Lugar", "given": "Marija", "initials": "M"}, {"family": "Eugster", "given": "Anne", "initials": "A"}, {"family": "Achenbach", "given": "Peter", "initials": "P"}, {"family": "von dem Berge", "given": "Thekla", "initials": "T"}, {"family": "Berner", "given": "Reinhard", "initials": "R"}, {"family": "Besser", "given": "Rachel E J", "initials": "REJ"}, {"family": "Casteels", "given": "Kristina", "initials": "K"}, {"family": "Elding Larsson", "given": "Helena", "initials": "H"}, {"family": "Gemulla", "given": "Gita", "initials": "G"}, {"family": "Kordonouri", "given": "Olga", "initials": "O"}, {"family": "Lindner", "given": "Annett", "initials": "A"}, {"family": "Lundgren", "given": "Markus", "initials": "M"}, {"family": "M\u00fcller", "given": "Denise", "initials": "D"}, {"family": "Oltarzewski", "given": "Mariusz", "initials": "M"}, {"family": "Rochtus", "given": "Anne", "initials": "A"}, {"family": "Scholz", "given": "Marlon", "initials": "M"}, {"family": "Szypowska", "given": "Agnieszka", "initials": "A"}, {"family": "Todd", "given": "John A", "initials": "JA"}, {"family": "Ziegler", "given": "Anette-Gabriele", "initials": "A"}, {"family": "Bonifacio", "given": "Ezio", "initials": "E"}, {"family": "GPPAD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-09-26", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484", "volume": "330", "issue": "12", "pages": "1151-1160"}, "abstract": "The incidence of diabetes in childhood has increased during the COVID-19 pandemic. Elucidating whether SARS-CoV-2 infection is associated with islet autoimmunity, which precedes type 1 diabetes onset, is relevant to disease etiology and future childhood diabetes trends.\r\n\r\nTo determine whether there is a temporal relationship between SARS-CoV-2 infection and the development of islet autoimmunity in early childhood.\r\n\r\nBetween February 2018 and March 2021, the Primary Oral Insulin Trial, a European multicenter study, enrolled 1050 infants (517 girls) aged 4 to 7 months with a more than 10% genetically defined risk of type 1 diabetes. Children were followed up through September 2022.\r\n\r\nSARS-CoV-2 infection identified by SARS-CoV-2 antibody development in follow-up visits conducted at 2- to 6-month intervals until age 2 years from April 2018 through June 2022.\r\n\r\nThe development of multiple (\u22652) islet autoantibodies in follow-up in consecutive samples or single islet antibodies and type 1 diabetes. Antibody incidence rates and risk of developing islet autoantibodies were analyzed.\r\n\r\nConsent was obtained for 885 (441 girls) children who were included in follow-up antibody measurements from age 6 months. SARS-CoV-2 antibodies developed in 170 children at a median age of 18 months (range, 6-25 months). Islet autoantibodies developed in 60 children. Six of these children tested positive for islet autoantibodies at the same time as they tested positive for SARS-CoV-2 antibodies and 6 at the visit after having tested positive for SARS-CoV-2 antibodies. The sex-, age-, and country-adjusted hazard ratio for developing islet autoantibodies when the children tested positive for SARS-CoV-2 antibodies was 3.5 (95% CI, 1.6-7.7; P = .002). The incidence rate of islet autoantibodies was 3.5 (95% CI, 2.2-5.1) per 100 person-years in children without SARS-CoV-2 antibodies and 7.8 (95% CI, 5.3-19.0) per 100 person-years in children with SARS-CoV-2 antibodies (P = .02). Islet autoantibody risk in children with SARS-CoV-2 antibodies was associated with younger age (<18 months) of SARS-CoV-2 antibody development (HR, 5.3; 95% CI, 1.5-18.3; P = .009).\r\n\r\nIn young children with high genetic risk of type 1 diabetes, SARS-CoV-2 infection was temporally associated with the development of islet autoantibodies.", "doi": "10.1001/jama.2023.16348", "pmid": "37682551", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10523173"}, {"db": "pii", "key": "2809621"}], "notes": [], "created": "2023-10-06T06:52:51.234Z", "modified": "2023-10-06T09:57:19.959Z"}, {"entity": "publication", "iuid": "063d887726bc402ea8c328b197fd1246", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/063d887726bc402ea8c328b197fd1246.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/063d887726bc402ea8c328b197fd1246"}}, "title": "Risk factors for ventilator-associated lower respiratory tract infection in COVID-19, a retrospective multicenter cohort study in Sweden.", "authors": [{"family": "Forsberg", "given": "Gustaf", "initials": "G"}, {"family": "Taxbro", "given": "Knut", "initials": "K", "orcid": "0000-0001-8711-9044", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53d41b4a81184f4da24af4065e0371e1.json"}}, {"family": "Elander", "given": "Louise", "initials": "L"}, {"family": "Hanberger", "given": "H\u00e5kan", "initials": "H"}, {"family": "Berg", "given": "S\u00f6ren", "initials": "S"}, {"family": "Idh", "given": "Jonna", "initials": "J"}, {"family": "Berkius", "given": "Johan", "initials": "J"}, {"family": "Ekman", "given": "Andreas", "initials": "A", "orcid": "0000-0001-6939-3365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6d19bd5b69440dcbdb168c292ba435f.json"}}, {"family": "Hammarskj\u00f6ld", "given": "Fredrik", "initials": "F"}, {"family": "Niward", "given": "Katarina", "initials": "K"}, {"family": "Balkhed", "given": "\u00c5se \u00d6stholm", "initials": "\u00c5\u00d6"}], "type": "journal article", "published": "2023-09-26", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": null, "issue": null, "pages": null}, "abstract": "Ventilator-associated lower respiratory tract infections (VA-LRTI) increase morbidity and mortality in intensive care unit (ICU) patients. Higher incidences of VA-LRTI have been reported among COVID-19 patients requiring invasive mechanical ventilation (IMV). The primary objectives of this study were to describe clinical characteristics, incidence, and risk factors comparing patients who developed VA-LRTI to patients who did not, in a cohort of Swedish ICU patients with acute hypoxemic respiratory failure due to COVID-19. Secondary objectives were to decipher changes over the three initial pandemic waves, common microbiology and the effect of VA-LTRI on morbidity and mortality.\r\n\r\nWe conducted a multicenter, retrospective cohort study of all patients admitted to 10 ICUs in southeast Sweden between March 1, 2020 and May 31, 2021 because of acute hypoxemic respiratory failure due to COVID-19 and were mechanically ventilated for at least 48 h. The primary outcome was culture verified VA-LRTI. Patient characteristics, ICU management, clinical course, treatments, microbiological findings, and mortality were registered. Logistic regression analysis was conducted to determine risk factors for first VA-LRTI.\r\n\r\nOf a total of 536 included patients, 153 (28.5%) developed VA-LRTI. Incidence rate of first VA-LRTI was 20.8 per 1000 days of IMV. Comparing patients with VA-LRTI to those without, no differences in mortality, age, sex, or number of comorbidities were found. Patients with VA-LRTI had fewer ventilator-free days, longer ICU stay, were more frequently ventilated in prone position, received corticosteroids more often and were more frequently on antibiotics at intubation. Regression analysis revealed increased adjusted odds-ratio (aOR) for first VA-LRTI in patients treated with corticosteroids (aOR 2.64 [95% confidence interval [CI]] [1.31-5.74]), antibiotics at intubation (aOR 2.01 95% CI [1.14-3.66]), and days of IMV (aOR 1.05 per day of IMV, 95% CI [1.03-1.07]). Few multidrug-resistant pathogens were identified. Incidence of VA-LRTI increased from 14.5 per 1000 days of IMV during the first wave to 24.8 per 1000 days of IMV during the subsequent waves.\r\n\r\nWe report a high incidence of culture-verified VA-LRTI in a cohort of critically ill COVID-19 patients from the first three pandemic waves. VA-LRTI was associated with increased morbidity but not 30-, 60-, or 90-day mortality. Corticosteroid treatment, antibiotics at intubation and time on IMV were associated with increased aOR of first VA-LRTI.", "doi": "10.1111/aas.14338", "pmid": "37751991", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:56:11.830Z", "modified": "2023-10-06T11:13:26.767Z"}, {"entity": "publication", "iuid": "15bb56bcd03e462bb05082b9dfbfffd4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15bb56bcd03e462bb05082b9dfbfffd4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15bb56bcd03e462bb05082b9dfbfffd4"}}, "title": "Outpatient Treatment with AZD7442 (Tixagevimab/Cilgavimab) Prevented COVID-19 Hospitalizations over 6 Months and Reduced Symptom Progression in the TACKLE Randomized Trial.", "authors": [{"family": "Hobbs", "given": "F D Richard", "initials": "FDR"}, {"family": "Montgomery", "given": "Hugh", "initials": "H"}, {"family": "Padilla", "given": "Francisco", "initials": "F"}, {"family": "Sim\u00f3n-Campos", "given": "Jesus Abraham", "initials": "JA"}, {"family": "Kim", "given": "Kenneth", "initials": "K"}, {"family": "Arbetter", "given": "Douglas", "initials": "D"}, {"family": "Padilla", "given": "Kelly W", "initials": "KW"}, {"family": "Reddy", "given": "Venkatesh Pilla", "initials": "VP"}, {"family": "Seegobin", "given": "Seth", "initials": "S"}, {"family": "Streicher", "given": "Katie", "initials": "K"}, {"family": "Templeton", "given": "Alison", "initials": "A"}, {"family": "Viani", "given": "Rolando M", "initials": "RM"}, {"family": "Johnsson", "given": "Eva", "initials": "E"}, {"family": "Koh", "given": "Gavin C K W", "initials": "GCKW"}, {"family": "Esser", "given": "Mark T", "initials": "MT"}], "type": "journal article", "published": "2023-09-26", "journal": {"title": "Infect Dis Ther", "issn": "2193-8229", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "We assessed effects of AZD7442 (tixagevimab/cilgavimab) on deaths from any cause or hospitalizations due to coronavirus disease 2019 (COVID-19) and symptom severity and longer-term safety in the TACKLE adult outpatient treatment study.\r\n\r\nParticipants received 600 mg AZD7442 (n = 452) or placebo (n = 451) \u2264 7 days of COVID-19 symptom onset.\r\n\r\nDeath from any cause or hospitalization for COVID-19 complications or sequelae through day 169 (key secondary endpoint) occurred in 20/399 (5.0%) participants receiving AZD7442 versus 40/407 (9.8%) receiving placebo [relative risk reduction (RRR) 49.1%; 95% confidence interval (CI) 14.5, 69.7; p = 0.009] or 50.7% (95% CI 17.5, 70.5; p = 0.006) after excluding participants unblinded before day 169 for consideration of vaccination). AZD7442 reduced progression of COVID-19 symptoms versus placebo through to day 29 (RRR 12.5%; 95% CI 0.5, 23.0) and improved most symptoms within 1-2 weeks. Over median safety follow-up of 170 days, adverse events occurred in 174 (38.5%) and 196 (43.5%) participants receiving AZD7442 or placebo, respectively. Cardiac serious adverse events occurred in two (0.4%) and three (0.7%) participants receiving AZD7442 or placebo, respectively.\r\n\r\nAZD7442 was well tolerated and reduced hospitalization and mortality through 6 months, and symptom burden through 29 days, in outpatients with mild-to-moderate COVID-19.\r\n\r\nClinicaltrials.gov, NCT04723394. ( https://beta.\r\n\r\ngov/study/NCT04723394 ).", "doi": "10.1007/s40121-023-00861-7", "pmid": "37751015", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40121-023-00861-7"}, {"db": "ClinicalTrials.gov", "key": "NCT04723394"}], "notes": [], "created": "2023-10-06T06:56:24.780Z", "modified": "2023-10-06T11:17:53.372Z"}, {"entity": "publication", "iuid": "d2b12b12e20c4ab0b118cffb5ad29b1a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d2b12b12e20c4ab0b118cffb5ad29b1a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d2b12b12e20c4ab0b118cffb5ad29b1a"}}, "title": "New-Onset Diabetes Mellitus in COVID-19: A Scoping Review.", "authors": [{"family": "Pantea Stoian", "given": "Anca", "initials": "A"}, {"family": "Bica", "given": "Ioana-Cristina", "initials": "I"}, {"family": "Salmen", "given": "Teodor", "initials": "T"}, {"family": "Al Mahmeed", "given": "Wael", "initials": "W"}, {"family": "Al-Rasadi", "given": "Khalid", "initials": "K"}, {"family": "Al-Alawi", "given": "Kamila", "initials": "K"}, {"family": "Banach", "given": "Maciej", "initials": "M"}, {"family": "Banerjee", "given": "Yajnavalka", "initials": "Y"}, {"family": "Ceriello", "given": "Antonio", "initials": "A"}, {"family": "Cesur", "given": "Mustafa", "initials": "M"}, {"family": "Cosentino", "given": "Francesco", "initials": "F"}, {"family": "Firenze", "given": "Alberto", "initials": "A"}, {"family": "Galia", "given": "Massimo", "initials": "M"}, {"family": "Goh", "given": "Su-Yen", "initials": "S"}, {"family": "Janez", "given": "Andrej", "initials": "A"}, {"family": "Kalra", "given": "Sanjay", "initials": "S"}, {"family": "Kapoor", "given": "Nitin", "initials": "N"}, {"family": "Kempler", "given": "Peter", "initials": "P"}, {"family": "Lessan", "given": "Nader", "initials": "N"}, {"family": "Lotufo", "given": "Paulo", "initials": "P"}, {"family": "Mikhaildiis", "given": "Dimitri P", "initials": "DP"}, {"family": "Nibali", "given": "Luigi", "initials": "L"}, {"family": "Papanas", "given": "Nikolaos", "initials": "N"}, {"family": "Powell-Wiley", "given": "Tiffany", "initials": "T"}, {"family": "Rizvi", "given": "Ali A", "initials": "AA"}, {"family": "Sahebkar", "given": "Amirhossein", "initials": "A"}, {"family": "Santos", "given": "Raul D", "initials": "RD"}, {"family": "Toth", "given": "Peter P", "initials": "PP"}, {"family": "Viswanathan", "given": "Vijay", "initials": "V"}, {"family": "Rizzo", "given": "Manfredi", "initials": "M"}, {"family": "Cardiometabolic Panel of International Experts on Syndemic COVID-19 (CAPISCO)", "given": "", "initials": ""}], "type": "journal article", "published": "2023-09-26", "journal": {"title": "Diabetes Ther", "issn": "1869-6953", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic became superimposed on the pre-existing obesity and diabetes mellitus (DM) pandemics. Since COVID-19 infection alters the metabolic equilibrium, it may induce pathophysiologic mechanisms that potentiate new-onset DM, and we evaluated this issue.\r\n\r\nA systematic review of the literature published from the 1 January 2020 until the 20 July 2023 was performed (PROSPERO registration number CRD42022341638). We included only full-text articles of both human clinical and randomized controlled trials published in English and enrolling adults (age > 18 years old) with ongoing or preceding COVID-19 in whom hyperglycemia was detected. The search was based on the following criteria: \"(new-onset diabetes mellitus OR new-onset DM) AND (COVID-19) AND adults\".\r\n\r\nArticles on MEDLINE (n = 70) and the Web of Science database (n = 16) were included and analyzed by two researchers who selected 20 relevant articles. We found evidence of a bidirectional relationship between COVID-19 and DM.\r\n\r\nThis link operates as a pathophysiological mechanism supported by epidemiological data and also by the clinical and biological findings obtained from the affected individuals. The COVID-19 pandemic raised the incidence of DM through different pathophysiological and psychosocial factors.", "doi": "10.1007/s13300-023-01465-7", "pmid": "37751143", "labels": {"Category: Health": null, "Category: Post-COVID": null, "Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s13300-023-01465-7"}], "notes": [], "created": "2023-10-06T06:56:19.951Z", "modified": "2023-10-06T11:16:20.895Z"}, {"entity": "publication", "iuid": "857986e34e8c45918f8e99832b77fba3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/857986e34e8c45918f8e99832b77fba3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/857986e34e8c45918f8e99832b77fba3"}}, "title": "Effects of remdesivir on SARS-CoV-2 viral dynamics and mortality in viraemic patients hospitalized for COVID-19.", "authors": [{"family": "Hagman", "given": "Karl", "initials": "K", "orcid": "0000-0002-5965-6130", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f57f6a390d6f4000ab75562643872ef7.json"}}, {"family": "Hedenstierna", "given": "Magnus", "initials": "M", "orcid": "0000-0001-8539-9820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/561a8bfc411142ab8dc9c4e1bffa93da.json"}}, {"family": "Widaeus", "given": "Jacob", "initials": "J"}, {"family": "Arvidsson", "given": "Emelie", "initials": "E"}, {"family": "Hammas", "given": "Berit", "initials": "B"}, {"family": "Grillner", "given": "Lena", "initials": "L"}, {"family": "Jakobsson", "given": "Jan", "initials": "J", "orcid": "0000-0002-5829-1803", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/940a993e912e4b6e98b913efe6c0c08d.json"}}, {"family": "Gille-Johnson", "given": "Patrik", "initials": "P"}, {"family": "Ursing", "given": "Johan", "initials": "J", "orcid": "0000-0002-5508-9327", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88f0c4ae034f4078869e7b9e85ff2d4e.json"}}], "type": "journal article", "published": "2023-09-26", "journal": {"title": "J Antimicrob Chemother", "issn": "1460-2091", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Studies on the antiviral effects of remdesivir have shown conflicting results. SARS-CoV-2 viraemia could identify patients in whom antiviral treatment may be particularly beneficial.\r\n\r\nTo investigate antiviral effects and clinical outcomes of remdesivir treatment in viraemic patients.\r\n\r\nViraemic patients hospitalized for COVID-19 with ratio of arterial oxygen partial pressure to fractional inspired oxygen of \u2264300, symptom duration \u226410 days, and estimated glomerular filtration rate \u226530 mL/min were included in a cohort. The rate of serum viral clearance and serum viral load decline, 60 day mortality and in-hospital outcomes were estimated. A subgroup analysis including patients with symptom duration \u22647 days was performed.\r\n\r\nA total of 318 viraemic patients were included. Thirty-three percent (105/318) received remdesivir. The rate of serum viral clearance [subhazard risk ratio (SHR) 1.4 (95% CI 0.9-2.0), P = 0.11] and serum viral load decline (P = 0.11) were not significantly different between remdesivir-treated patients and controls. However, the rate of serum viral clearance was non-significantly higher [SHR 1.6 (95% CI 1.0-2.7), P = 0.051] and the viral load decline was faster (P = 0.03) in remdesivir-treated patients with symptom duration \u22647 days at admission. The 60 day mortality [HR 1.0 (95% CI 0.6-1.8), P = 0.97] and adverse in-hospital outcomes [OR 1.4 (95% CI 0.8-2.4), P = 0.31] were not significantly different between remdesivir-treated patients and controls.\r\n\r\nRemdesivir treatment did not significantly change the duration of SARS-CoV-2 viraemia, decline of serum viral load, 60 day mortality or in-hospital adverse outcomes in patients with \u226410 days of symptoms at admission. Remdesivir appeared to reduce the duration of viraemia in a subgroup of patients with \u22647 days of symptoms at admission.", "doi": "10.1093/jac/dkad295", "pmid": "37757451", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7283037"}], "notes": [], "created": "2023-10-06T06:53:00.945Z", "modified": "2023-10-06T10:44:02.277Z"}, {"entity": "publication", "iuid": "7b077a08a6e844f7990e9a5e1d9f9d1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b077a08a6e844f7990e9a5e1d9f9d1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b077a08a6e844f7990e9a5e1d9f9d1d"}}, "title": "De novo design of anti-variant COVID-19 vaccine.", "authors": [{"family": "Goswami", "given": "Arpita", "initials": "A", "orcid": "0000-0001-5632-1610", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4b47cfbebb0432ab41fd84d5d227da6.json"}}, {"family": "Kumar", "given": "Madan", "initials": "M"}, {"family": "Ullah", "given": "Samee", "initials": "S", "orcid": "0000-0003-1987-3672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eca60a20784249e9a7ac35c2b394c79b.json"}}, {"family": "Gore", "given": "Milind M", "initials": "MM"}], "type": "journal article", "published": "2023-09-26", "journal": {"title": "Biol Methods Protoc", "issn": "2396-8923", "issn-l": null, "volume": "8", "issue": "1", "pages": "bpad021"}, "abstract": "Recent studies highlight the effectiveness of hybrid Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) vaccines combining wild-type nucleocapsid and Spike proteins. We have further enhanced this strategy by incorporating delta and omicron variants' spike protein mutations. Both delta and omicron mark the shifts in viral transmissibility and severity in unvaccinated and vaccinated patients. So their mutations are highly crucial for future viral variants also. Omicron is particularly adept at immune evasion by mutating spike epitopes. The rapid adaptations of Omicron and sub-variants to spike-based vaccines and simultaneous transmissibility underline the urgency for new vaccines in the continuous battle against SARS-CoV-2. Therefore, we have added three persistent T-cell-stimulating nucleocapsid peptides similar to homologous sequences from seasonal Human Coronaviruses (HuCoV) and an envelope peptide that elicits a strong T-cell immune response. These peptides are clustered in the hybrid spike's cytoplasmic region with non-immunogenic linkers, enabling systematic arrangement. AlphaFold (Artificial intelligence-based model building) analysis suggests omitting the transmembrane domain enhances these cytoplasmic epitopes' folding efficiency which can ensure persistent immunity for CD4+ structural epitopes. Further molecular dynamics simulations validate the compact conformation of the modeled structures and a flexible C-terminus region. Overall, the structures show stability and less conformational fluctuation throughout the simulation. Also, the AlphaFold predicted structural epitopes maintained their folds during simulation to ensure the specificity of CD4+ T-cell response after vaccination. Our proposed approach may provide options for incorporating diverse anti-viral T-cell peptides, similar to HuCoV, into linker regions. This versatility can be promising to address outbreaks and challenges posed by various viruses for effective management in this era of innovative vaccines.", "doi": "10.1093/biomethods/bpad021", "pmid": "37854896", "labels": {"Category: Proteins": null, "Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10580973"}, {"db": "pii", "key": "bpad021"}], "notes": [], "created": "2023-11-01T13:34:12.261Z", "modified": "2023-11-02T07:44:07.338Z"}, {"entity": "publication", "iuid": "79fe4e4fd2ff463795217ce03e9c6ffc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79fe4e4fd2ff463795217ce03e9c6ffc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79fe4e4fd2ff463795217ce03e9c6ffc"}}, "title": "Comprehensive proteomics and meta-analysis of COVID-19 host response.", "authors": [{"family": "Baba\u010di\u0107", "given": "Haris", "initials": "H", "orcid": "0000-0003-0813-0005", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd5aeeb249db49e08f44314024fae6ef.json"}}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f2dc27d02294a15a6f691be6aab641f.json"}}, {"family": "Ara\u00fajo", "given": "Jos\u00e9 Eduardo", "initials": "JE"}, {"family": "Mermelekas", "given": "Georgios", "initials": "G"}, {"family": "Sharma", "given": "Nidhi", "initials": "N"}, {"family": "Tynell", "given": "Janne", "initials": "J", "orcid": "0000-0001-6930-5230", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/239eab38958f497f9162b6f37610ab73.json"}}, {"family": "Garc\u00eda", "given": "Marina", "initials": "M", "orcid": "0000-0002-9130-3933", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5b109d7a54e4c05a48e0f21c4432be6.json"}}, {"family": "Varnaite", "given": "Renata", "initials": "R"}, {"family": "Asgeirsson", "given": "Hilmir", "initials": "H", "orcid": "0000-0003-3869-8021", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/870e3520475b41f8a4f39744b1ecb3ea.json"}}, {"family": "Glans", "given": "Hedvig", "initials": "H"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J", "orcid": "0000-0002-8100-9562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4eb7262dfac84b819fe79856e96eaf76.json"}}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Pernemalm", "given": "Maria", "initials": "M", "orcid": "0000-0003-4624-031X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6801d3242ee544a59d77ccd7256a4a30.json"}}], "type": "meta-analysis", "published": "2023-09-22", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "14", "issue": "1", "pages": "5921"}, "abstract": "COVID-19 is characterised by systemic immunological perturbations in the human body, which can lead to multi-organ damage. Many of these processes are considered to be mediated by the blood. Therefore, to better understand the systemic host response to SARS-CoV-2 infection, we performed systematic analyses of the circulating, soluble proteins in the blood through global proteomics by mass-spectrometry (MS) proteomics. Here, we show that a large part of the soluble blood proteome is altered in COVID-19, among them elevated levels of interferon-induced and proteasomal proteins. Some proteins that have alternating levels in human cells after a SARS-CoV-2 infection in vitro and in different organs of COVID-19 patients are deregulated in the blood, suggesting shared infection-related changes.The availability of different public proteomic resources on soluble blood proteome alterations leaves uncertainty about the change of a given protein during COVID-19. Hence, we performed a systematic review and meta-analysis of MS global proteomics studies of soluble blood proteomes, including up to 1706 individuals (1039 COVID-19 patients), to provide concluding estimates for the alteration of 1517 soluble blood proteins in COVID-19. Finally, based on the meta-analysis we developed CoViMAPP, an open-access resource for effect sizes of alterations and diagnostic potential of soluble blood proteins in COVID-19, which is publicly available for the research, clinical, and academic community.", "doi": "10.1038/s41467-023-41159-z", "pmid": "37739942", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Other": null, "Funder: KAW/SciLifeLab": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC10516886"}, {"db": "pii", "key": "10.1038/s41467-023-41159-z"}], "notes": [], "created": "2023-10-06T06:52:08.783Z", "modified": "2023-10-06T08:17:43.169Z"}, {"entity": "publication", "iuid": "6df48cf185f94d4d8d35cfe2c6b33d1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6df48cf185f94d4d8d35cfe2c6b33d1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6df48cf185f94d4d8d35cfe2c6b33d1d"}}, "title": "What Is the Impact of the Novel Coronavirus and the Vaccination on Guillain-Barre Syndrome?", "authors": [{"family": "Chen", "given": "Yinuo", "initials": "Y"}, {"family": "Li", "given": "Kezheng", "initials": "K"}, {"family": "Lv", "given": "Wenjing", "initials": "W"}, {"family": "Xie", "given": "Jiali", "initials": "J"}, {"family": "Qian", "given": "Yuqin", "initials": "Y"}, {"family": "Cui", "given": "Can", "initials": "C"}, {"family": "Deng", "given": "Binbin", "initials": "B", "orcid": "0000-0002-4058-0738", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/592a6c15241f467cb88b21a1853ed8be.json"}}], "type": "journal article", "published": "2023-09-20", "journal": {"title": "Mol Neurobiol", "issn": "1559-1182", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has resulted in devastating medical and economic consequences worldwide over the past 3 years. As the pandemic enters a new stage, it is essential to consider the potential impact on rare diseases such as Guillain-Barre syndrome (GBS), which has been intimately associated with COVID-19 since the first COVID-19-related GBS case was reported in January 2020. There are notable differences between COVID-19-related GBS and GBS without COVID-19 in terms of diagnostic types and clinical manifestations. Furthermore, with the widespread administration of COVID-19 vaccines, there have been reports of GBS occurring shortly after vaccination, which requires close attention despite its rarity. This review also explores the vaccines associated with heightened GBS risks, offering insights that may guide vaccination policies and clinical practice. To provide a visual summary of these findings, we have included a graphical abstract. This article will discuss the characteristic manifestations of GBS patients after being positive for the novel coronavirus and the safety of several COVID-19 vaccines. Firstly, this article comprehensively expounds and discusses the epidemiological aspects of novel coronavirus-related GBS. For example, from the perspective of the same population, the expected incidence of GBS in the COVID-19-positive population (persons/100,000 persons/ year) is about 43 times that of the COVID-19-negative population, and the incidence of GBS is significantly increased. Secondly, the clinical characteristics of COVID-19-negative GBS patients and SARS-CoV-2-GBS (SC2-GBS) patients were summarized and compared. Thirdly, this article reviews GBS cases in the current adverse events after COVID-19 vaccination and analyzes and discusses from multiple perspectives, such as the incidence of GBS events, the age proportion of patients, and the interval of onset.", "doi": "10.1007/s12035-023-03638-8", "pmid": "37728848", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "10.1007/s12035-023-03638-8"}], "notes": [], "created": "2023-10-06T06:52:20.586Z", "modified": "2023-10-06T08:47:40.883Z"}, {"entity": "publication", "iuid": "9fab0e58ed044f48bdcf82502fdbfc0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9fab0e58ed044f48bdcf82502fdbfc0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9fab0e58ed044f48bdcf82502fdbfc0e"}}, "title": "Strict self-isolation did not protect Swedish cancer patients on active treatment from the risk of becoming seropositive for SARS-CoV-2.", "authors": [{"family": "Ginman", "given": "Beatrice", "initials": "B"}, {"family": "Pahnke", "given": "Simon", "initials": "S", "orcid": "0000-0002-3541-2027", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f7056035dab4a0080d35b40977463a8.json"}}, {"family": "Freyhult", "given": "Eva", "initials": "E"}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Kolstad", "given": "Linda", "initials": "L"}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Hamberg Levedahl", "given": "Kerstin", "initials": "K"}, {"family": "Enblad", "given": "Gunilla", "initials": "G"}, {"family": "Glimelius", "given": "Ingrid", "initials": "I", "orcid": "0000-0001-6158-3041", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4407b480fb244249063d1cc74513c67.json"}}], "type": "journal article", "published": "2023-09-20", "journal": {"title": "Acta Oncol", "issn": "1651-226X", "issn-l": null, "volume": null, "issue": null, "pages": "1-9"}, "abstract": "Background: Swedish recommendations to reduce the risk of COVID-19 relied on each citizen's own sense of responsibility rather than mandatory lockdowns. We studied how COVID-19-related self-isolation and anxiety correlated to SARS-CoV-2 seropositivity and PCR-positivity in patients with active cancer treatment.Methods: In a longitudinal cohort study at Uppsala University Hospital patients and cancer personnel were included between April 1st 2020 to August 1st 2020. Serological testing for SARS-CoV-2 was done every 8-12-weeks until 30 March 2021. Patients completed a survey at inclusion regarding self-reported COVID-19-related anxiety and self-isolation.Results: A total of 622 patients [n = 475 with solid malignancies (SM), n = 147 with haematological malignancies (HM)], and 358 healthcare personnel were included. The seropositivity rate was lower for patients than for personnel; 10.5% for SM patients, 6.8% for HM patients, and 16.2% for personnel (p = 0.005). Strict adherence to self-isolation guidelines was reported by 54% of patients but was not associated with a lower risk of becoming seropositive [OR = 1.4 (0.8-2.5), p = 0.2]. High anxiety was expressed by 32% of patients, more often by SM patients than HM patients (34% vs 25% [OR = 1.6 (1.1-2.5, p = 0.03)]). Female gender [OR = 3.5 (2.4-5.2), p < 0.001] and being born outside of Europe [OR = 2.9 (1.4-6.4), p = 0.007] were both associated with high anxiety. Patients reporting high anxiety became seropositive to a similar degree as those with low anxiety [OR = 0.7 (0.3-1.2), p = 0.2]. HM patients with PCR-positive COVID-19 were more likely than SM patients to require oxygen therapy, including non-invasive ventilation/intubation (69% vs. 26%, p = 0.005).Conclusion: For Swedish patients on active cancer treatment, high self-assessed COVID-19-related anxiety or strict adherence to self-isolation guidelines were not associated with a lower risk of COVID-19. Patients with HM were less likely to develop serological antibody response after COVID-19 and were more likely to require advanced hospital care, but expressed less COVID-19-related anxiety than patients with SM.", "doi": "10.1080/0284186X.2023.2257873", "pmid": "37729083", "labels": {"Category: Health": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Social Science & Humanities": null, "Category: Serology": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:52:22.926Z", "modified": "2023-10-06T08:49:11.876Z"}, {"entity": "publication", "iuid": "4260eeddc24f443e8616014380ebb666", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4260eeddc24f443e8616014380ebb666.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4260eeddc24f443e8616014380ebb666"}}, "title": "Predictors of the post-COVID condition following mild SARS-CoV-2 infection.", "authors": [{"family": "Reme", "given": "B-A", "initials": "B"}, {"family": "Gjesvik", "given": "J", "initials": "J"}, {"family": "Magnusson", "given": "K", "initials": "K", "orcid": "0000-0003-4851-5794", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2fe6a28f36f40a998b8c9fc3c5ebe73.json"}}], "type": "journal article", "published": "2023-09-20", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "14", "issue": "1", "pages": "5839"}, "abstract": "Whereas the nature of the post-COVID condition following mild acute COVID-19 is increasingly well described in the literature, knowledge of its risk factors, and whether it can be predicted, remains limited. This study, conducted in Norway, uses individual-level register data from 214,667 SARS-CoV-2 infected individuals covering a range of demographic, socioeconomic factors, as well as cause-specific healthcare utilization in the years prior to infection to assess the risk of post-COVID complaints \u22653 months after testing positive. We find that the risk of post-COVID was higher among individuals who prior to infection had been diagnosed with psychological (OR = 2.12, 95% CI 1.84-2.44), respiratory (OR = 2.03, 95% CI 1.78-2.32), or general and unspecified health problems (OR = 1.78, 95% CI 1.52-2.09). To assess the predictability of post-COVID after mild initial disease, we use machine learning methods and find that pre-infection characteristics, combined with information on the SARS-CoV-2 virus type and vaccine status, to a considerable extent (AUC = 0.79, 95% CI 0.75-0.81) could predict the occurrence of post-COVID complaints in our sample.", "doi": "10.1038/s41467-023-41541-x", "pmid": "37730740", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC10511472"}, {"db": "pii", "key": "10.1038/s41467-023-41541-x"}], "notes": [], "created": "2023-10-06T12:26:24.681Z", "modified": "2023-10-06T12:32:45.559Z"}, {"entity": "publication", "iuid": "07d0b69a0592471ba8f3f12bccd0b798", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07d0b69a0592471ba8f3f12bccd0b798.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07d0b69a0592471ba8f3f12bccd0b798"}}, "title": "Mental health, stress, and well-being measured before (2019) and during (2020) COVID-19: a Swedish socioeconomic population-based study.", "authors": [{"family": "Lindqvist Bagge", "given": "Ann-Sophie", "initials": "A"}, {"family": "Lekander", "given": "Mats", "initials": "M", "orcid": "0000-0003-3998-1494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e04a9b05c67472980549da294267381.json"}}, {"family": "Olofsson Bagge", "given": "Roger", "initials": "R", "orcid": "0000-0001-5795-0355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0502c52a1b65446fa2e4b726906c9d51.json"}}, {"family": "Carlander", "given": "Anders", "initials": "A", "orcid": "0000-0002-4435-7648", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb81228e2951462ab407f261fa9e6d02.json"}}], "type": "journal article", "published": "2023-09-20", "journal": {"title": "Psychol Health", "issn": "1476-8321", "issn-l": null, "volume": null, "issue": null, "pages": "1-18"}, "abstract": "Compare mental health, stress, and well-being in the Swedish population as measured before and during the COVID-19 pandemic.\r\n\r\nRepeated cross-sectional design using data measured before (Jan-2019; n = 2791) and during (Oct/Nov-2020; n = 2926) COVID-19 pandemic in Swedish population-representative cohorts. Following constructs were measured: anxiety (Beck Anxiety Inventory), depression (Beck Depression Inventory-II), stress (Perceived Stress Scale-10 items), health-related quality of life (HRQOL[Functional Assessment of Cancer Therapy-General Population]) and self-rated health (SRH) was assessed with a single-item question.\r\n\r\nWhen adjusting for age, sex, education, and income there were significantly higher levels of anxiety (M\u0302 = 9.15 vs. 8.48, p < 0.01) and depression (M\u0302 = 3.64 vs. 3.30, p = 0.03), lower levels of stress (M\u0302 = 14.06 vs. 14.91, p < 0.001), but worsened HRQOL (M\u0302 = 76.40 vs. 77.92, p < 0.01) and SRH (M\u0302 = 6.91 vs. 7.20, p < 0.001), observed in 2020 compared to 2019. For the negative effects seen in anxiety, depression, HRQOL, and SRH, higher income and education had a protective effect. The decrease in stress was also correlated with higher income.\r\n\r\nThe COVID-19 pandemic led to a small but significant worsening in mental health and well-being in the general Swedish population, where higher socioeconomic status seemed to have a protective effect.", "doi": "10.1080/08870446.2023.2257747", "pmid": "37728316", "labels": {"Type: Journal article": null, "Funder: Forte": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:56:02.078Z", "modified": "2023-10-06T10:58:34.391Z"}, {"entity": "publication", "iuid": "c7faff32e1944754ad92588bd7d575fe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7faff32e1944754ad92588bd7d575fe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7faff32e1944754ad92588bd7d575fe"}}, "title": "Prevalence and impact of chronic dysglycaemia among patients with COVID-19 in Swedish intensive care units: a multicentre, retrospective cohort study.", "authors": [{"family": "Balintescu", "given": "Anca", "initials": "A", "orcid": "0000-0001-8665-5742", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/97e90fbd52e64ac7b6d6dbd91a2db88c.json"}}, {"family": "Rysz", "given": "Susanne", "initials": "S"}, {"family": "Hertz", "given": "Carl", "initials": "C"}, {"family": "Grip", "given": "Jonathan", "initials": "J"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Oldner", "given": "Anders", "initials": "A"}, {"family": "Svensen", "given": "Christer", "initials": "C"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}], "type": "observational study", "published": "2023-09-19", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "9", "pages": "e071330"}, "abstract": "Using glycated haemoglobin A1c (HbA1c) screening, we aimed to determine the prevalence of chronic dysglycaemia among patients with COVID-19 admitted to the intensive care unit (ICU). Additionally, we aimed to explore the association between chronic dysglycaemia and clinical outcomes related to ICU stay.\r\n\r\nMulticentre retrospective observational study.\r\n\r\nICUs in three hospitals in Stockholm, Sweden.\r\n\r\nCOVID-19 patients admitted to the ICU between 5 March 2020 and 13 August 2020 with available HbA1c at admission. Chronic dysglycaemia was determined based on previous diabetes history and HbA1c.\r\n\r\nPrimary outcome was the actual prevalence of chronic dysglycaemia (pre-diabetes, unknown diabetes or known diabetes) among COVID-19 patients. Secondary outcome was the association of chronic dysglycaemia with 90-day mortality, ICU length of stay, duration of invasive mechanical ventilation (IMV) and renal replacement therapy (RRT), accounting for treatment selection bias.\r\n\r\nA total of 308 patients with available admission HbA1c were included. Chronic dysglycaemia prevalence assessment was restricted to 206 patients admitted ICUs in which HbA1c was measured on all admitted patients. Chronic dysglycaemia was present in 82.0% (95% CI 76.1% to 87.0%) of patients, with pre-diabetes present in 40.2% (95% CI 33.5% to 47.3%), unknown diabetes in 20.9% (95% CI 15.5% to 27.1%), well-controlled diabetes in 7.8% (95% CI 4.5% to 12.3%) and uncontrolled diabetes in 13.1% (95% CI 8.8% to 18.5%). All patients with available HbA1c were included for the analysis of the relationship between chronic dysglycaemia and secondary outcomes. We found no independent association between chronic dysglycaemia and 90-day mortality, ICU length of stay or duration of IMV. After excluding patients with specific treatment limitations, no association between chronic dysglycaemia and RRT use was observed.\r\n\r\nIn our cohort of critically ill COVID-19 patients, the prevalence of chronic dysglycaemia was 82%. We found no robust associations between chronic dysglycaemia and clinical outcomes when accounting for treatment limitations.", "doi": "10.1136/bmjopen-2022-071330", "pmid": "37730398", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10510869"}, {"db": "pii", "key": "bmjopen-2022-071330"}], "notes": [], "created": "2023-10-06T06:56:14.282Z", "modified": "2023-10-06T11:14:23.235Z"}, {"entity": "publication", "iuid": "f33ccda0af204b66985f5a33d4c2b538", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f33ccda0af204b66985f5a33d4c2b538.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f33ccda0af204b66985f5a33d4c2b538"}}, "title": "The effect of COVID-19 pandemic on perioperative factors: data from the Swedish Perioperative Register.", "authors": [{"family": "Dahlberg", "given": "Karuna", "initials": "K"}, {"family": "M\u00e5nsson", "given": "Sandra", "initials": "S"}, {"family": "Lyckner", "given": "Sara", "initials": "S"}, {"family": "Lindgren", "given": "Lenita", "initials": "L"}, {"family": "Alm", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2023-09-16", "journal": {"title": "Perioper Med (Lond)", "issn": "2047-0525", "issn-l": null, "volume": "12", "issue": "1", "pages": "50"}, "abstract": "The COVID-19 pandemic has affected healthcare organizations in many areas. The aim of this study was to describe surgical interventions, anesthesia, and postoperative outcomes in adult patients during the first wave and 1 year into the COVID-19 pandemic in Sweden, and to compare these outcomes with outcomes during the same period the year before the pandemic.\r\n\r\nData were collected from the Swedish PeriOperative Register, and included 417, 233 perioperative registration of patients \u2265 18 years old between period 1 (March-June 2019), period 2 (March-June 2020), and period 3 (March-June 2021).\r\n\r\nCompared with pre-pandemic (period 1), the number of surgical interventions decreased by 28% in the first wave (period 2); 1 year into the pandemic (period 3), the number of interventions was still 7.5% lower than pre-pandemic. The largest drops between periods 1 and 2 were noted in the specialties of ear, nose, and larynx surgery, - 55.6%; teeth, jaws, mouth, and pharynx surgery, - 45.0%; endocrine system surgery, - 38.8%. The number of acute surgeries remained stable during all three periods. Volatiles were more frequently used for the maintenance of general anesthesia in period 2 than in either period 1 or 3 (p < 0.001). Minor differences were noted throughout the periods in postoperative nausea and vomiting as well as postoperative pain.\r\n\r\nThe COVID-19 pandemic has had an impact on perioperative care in Sweden. During the first wave of the pandemic, the number of surgical interventions decreased, but the number of acute surgeries remained stable compared with pre-pandemic numbers. Perioperative organizations have had and will continue to have challenges handling the increased number of patients needing perioperative care.", "doi": "10.1186/s13741-023-00340-0", "pmid": "37715220", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10504757"}, {"db": "pii", "key": "10.1186/s13741-023-00340-0"}], "notes": [], "created": "2023-10-06T06:56:04.609Z", "modified": "2023-10-06T11:03:20.841Z"}, {"entity": "publication", "iuid": "3ad2fcacd1ce42d7b2baae5a8fdf22d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ad2fcacd1ce42d7b2baae5a8fdf22d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ad2fcacd1ce42d7b2baae5a8fdf22d5"}}, "title": "3D printed fluidic swab for COVID-19 testing with improved diagnostic yield and user comfort.", "authors": [{"family": "Kim", "given": "Joochan", "initials": "J"}, {"family": "Jeon", "given": "Jaehyung", "initials": "J"}, {"family": "Jang", "given": "Hyowon", "initials": "H"}, {"family": "Moon", "given": "Youngkwang", "initials": "Y"}, {"family": "Abafogi", "given": "Abdurhaman Teyib", "initials": "AT"}, {"family": "van Noort", "given": "Danny", "initials": "D"}, {"family": "Lee", "given": "Jinkee", "initials": "J"}, {"family": "Kang", "given": "Taejoon", "initials": "T"}, {"family": "Park", "given": "Sungsu", "initials": "S", "orcid": "0000-0003-3062-1302", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b28d5fc9ffb046f7abe638dafddade3d.json"}}], "type": "journal article", "published": "2023-09-16", "journal": {"title": "Nano Converg", "issn": "2196-5404", "issn-l": null, "volume": "10", "issue": "1", "pages": "45"}, "abstract": "The current standard method of diagnosing coronavirus disease 2019 (COVID-19) involves uncomfortable and invasive nasopharyngeal (NP) sampling using cotton swabs (CS), which can be unsuitable for self-testing. Although mid-turbinate sampling is an alternative, it has a lower diagnostic yield than NP sampling. Nasal wash (NW) has a similar diagnostic yield to NP sampling, but is cumbersome to perform. In this study, we introduce a 3D printed fluidic swab (3DPFS) that enables easy NW sampling for COVID-19 testing with improved diagnostic yield. The 3DPFS comprises a swab head, microchannel, and socket that can be connected to a syringe containing 250 \u00b5L of NW solution. The 3DPFS efficiently collects nasal fluid from the surface of the nasal cavity, resulting in higher sensitivity than CS for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This was confirmed by both reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and lateral flow assays (LFA) in virus-spiked nasal samples and clinical samples. Additionally, users reported greater comfort when using the 3DPFS compared to CS. These findings suggest that the 3DPFS can improve the performance of COVID-19 testing by facilitating efficient and less painful nasal sample collection.", "doi": "10.1186/s40580-023-00393-3", "pmid": "37715925", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10505115"}, {"db": "pii", "key": "10.1186/s40580-023-00393-3"}], "notes": [], "created": "2023-10-06T06:52:38.148Z", "modified": "2023-10-06T09:42:51.637Z"}, {"entity": "publication", "iuid": "3a6b1ba2f32c4f01b56d2579e63069f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a6b1ba2f32c4f01b56d2579e63069f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a6b1ba2f32c4f01b56d2579e63069f8"}}, "title": "The impact of reduced worry on general functioning: A mediation analysis from a randomized trial.", "authors": [{"family": "Andersson", "given": "Erik", "initials": "E", "orcid": "0000-0003-0088-8719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5bd630b521ea445ca28887ae1f5d20b4.json"}}, {"family": "Mataix-Cols", "given": "David", "initials": "D"}, {"family": "Lauri", "given": "Klara Olofsdotter", "initials": "KO"}, {"family": "de Schipper", "given": "Elles", "initials": "E"}, {"family": "Lj\u00f3tsson", "given": "Brj\u00e1nn", "initials": "B"}, {"family": "Aspvall", "given": "Kristina", "initials": "K"}, {"family": "Wahlund", "given": "Tove", "initials": "T"}], "type": "journal article", "published": "2023-09-14", "journal": {"title": "Stress Health", "issn": "1532-2998", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Previous lab findings have indicated that excessive worry may impair cognitive performance and problem solving capabilities but it is unclear if excessive worry also leads to broader impairments in general functioning. We report a secondary process data analysis of a large randomized waitlist-controlled trial (N = 670) of a self-guided online psychological intervention for dysfunctional worry related to the Covid-19 pandemic. Specific aims were to investigate (1) if improvements in general functioning were mediated by reductions in worry related to Covid-19 during the acute intervention phase, and (2) if reduced worry related to Covid-19 during acute intervention phase had a positive long-term impact on general functioning up to 1 year after the end of the intervention. To address aim 1, we used a mediation analysis framework where outcome (general functioning measured with an adapted version of the Work and Social Adjustment Scale) and the hypothesized mediator (worry measured with an adapted version of the Generalised Anxiety Disorder 7-Item Scale) were administered weekly during the controlled phase of the trial of 3 weeks. To address aim 2, we investigated if reductions in worry during the 3-week treatment period predicted improved general functioning at 1- and 12 months after treatment completion. Results showed that improvements in general functioning at week 3 were mediated by reductions in worry during the first 2 weeks of treatment (indirect effect estimate -0.08; 95% CI -0.15, -0.02). A sensitivity analysis indicated that the mediation effects dropped significantly when the residual correlation values between the mediator and the outcome exceeded r = 0. A reversed causation model was not significant. Additionally, reductions in worry during treatment predicted subsequent improvements in general functioning at both 1- and 12-month follow-ups (p < .05, -.001). Altogether, these results provide further support of the importance of targeting worry as a way to improve functioning among the large population of individuals with high levels of worry.", "doi": "10.1002/smi.3319", "pmid": "37706604", "labels": {"Type: Journal article": null, "Funder: Vinnova": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:56:31.383Z", "modified": "2023-10-06T11:18:41.186Z"}, {"entity": "publication", "iuid": "b2ea537b86cd48ad914e5398382be59f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b2ea537b86cd48ad914e5398382be59f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b2ea537b86cd48ad914e5398382be59f"}}, "title": "Temporal trends in hospitalizations and 30-day mortality in older patients during the COVID pandemic from March 2020 to July 2021.", "authors": [{"family": "Garcia-Ptacek", "given": "Sara", "initials": "S"}, {"family": "Xu", "given": "Hong", "initials": "H", "orcid": "0000-0002-7266-3431", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3aac746da836497ea13b648daac184b9.json"}}, {"family": "Annetorp", "given": "Martin", "initials": "M"}, {"family": "Jerlardtz", "given": "Viktoria B\u00e4ck", "initials": "VB"}, {"family": "Cederholm", "given": "Tommy", "initials": "T"}, {"family": "Engstr\u00f6m", "given": "Malin", "initials": "M"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Lundberg", "given": "Lars G\u00f6ran", "initials": "LG"}, {"family": "Metzner", "given": "Carina", "initials": "C"}, {"family": "Olsson", "given": "Maria", "initials": "M"}, {"family": "Nyvang", "given": "Josefina Skog\u00f6", "initials": "JS"}, {"family": "S\u00fchl \u00d6berg", "given": "Carina", "initials": "C"}, {"family": "\u00c5kesson", "given": "Elisabet", "initials": "E"}, {"family": "Religa", "given": "Dorota", "initials": "D"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2023-09-14", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "9", "pages": "e0291237"}, "abstract": "A reduction in mortality risk of COVID-19 throughout the first wave of the pandemic has been reported, but less is known about later waves. This study aimed to describe changes in hospitalizations and mortality of patients receiving inpatient geriatric care for COVID-19 or other causes during the pandemic.\r\n\r\nPatients 70 years and older hospitalized in geriatric hospitals in Stockholm for COVID-19 or other causes between March 2020-July 2021 were included. Data on the incidence of COVID-positive cases and 30-day mortality of the total \u2265 70-year-old population, in relation to weekly hospitalizations and mortality after hospital admissions were analyzed. Findings The total number of hospitalizations was 5,320 for COVID-19 and 32,243 for non-COVID-cases. In COVID-patients, the 30-day mortality rate was highest at the beginning of the first wave (29% in March-April 2020), reached 17% at the second wave peak (November-December) followed by 11-13% in the third wave (March-July 2021). The mortality in non-COVID geriatric patients showed a similar trend, but of lower magnitude (5-10%). During the incidence peaks, COVID-19 hospitalizations displaced non-COVID geriatric patients.\r\n\r\nHospital admissions and 30-day mortality after hospitalizations for COVID-19 increased in periods of high community transmission, albeit with decreasing mortality rates from wave 1 to 3, with a probable vaccination effect in wave 3. Thus, the healthcare system could not compensate for the high community spread of COVID-19 during the pandemic peaks, which also led to displacing care for non-COVID geriatric patients.", "doi": "10.1371/journal.pone.0291237", "pmid": "37708110", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10501674"}, {"db": "pii", "key": "PONE-D-22-12713"}], "notes": [], "created": "2023-09-18T16:00:46.524Z", "modified": "2023-10-06T09:58:21.706Z"}, {"entity": "publication", "iuid": "12ec45c4a43444138c0f4a53b788417a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/12ec45c4a43444138c0f4a53b788417a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/12ec45c4a43444138c0f4a53b788417a"}}, "title": "Symptoms, care consumption, and healthcare costs in hospitalized patients during the first wave of the COVID-19 pandemic.", "authors": [{"family": "Ashman Kr\u00f6\u00f6nstr\u00f6m", "given": "Linda", "initials": "L", "orcid": "0000-0002-4148-4844", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b0b88c35426e4eab9f7ee67e704cf5cf.json"}}, {"family": "Lundgren-Nilsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Kjellby-Wendt", "given": "Gunilla", "initials": "G"}, {"family": "Stibrant Sunnerhagen", "given": "Katharina", "initials": "K"}], "type": "observational study", "published": "2023-09-14", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "9", "pages": "e0291548"}, "abstract": "We aimed to assess symptomatology post discharge from the hospital in patients with COVID-19 treated during the first wave of the COVID-19 pandemic, and to follow care consumption and healthcare costs six months post discharge.\r\n\r\nThis study was a descriptive observational study over time. Data were retrieved from the Sahlgrenska University (SU) hospital registry for patients admitted to an SU hospital during March 2020 to August 2020. Of these, 1014 received a questionnaire approximately six weeks post discharge regarding symptoms. Data regarding care consumption were retrieved from the registry in the Region V\u00e4stra G\u00f6taland for 529 (52.2%) patients who completed the questionnaire. Of these, 466 patients were included in the analysis of care consumption.\r\n\r\nThere was a reported decrease in mobility from admission to discharge in both men (p = 0.02) and women (p = 0.01). The costs of inpatient care amounted to a total of 9 601 459.20 Euro (EUR). Symptoms were reported in 436 (93.6%) patients post discharge, of which weight loss during COVID-19 was most common in both men (n = 220, 77.5%) and women (n = 107, 58.8%). During six-month follow-up, 409 (87%) patients consumed care. Of the registered visits, 868 (27.1%) were related to a COVID-19 diagnosis. The total sum of outpatient care (i.e. visits with a registered COVID-19 diagnosis) was 77 311.30 EUR.\r\n\r\nAt discharge from the hospital, there was a decrease in mobility. Most patients had remaining sequelae post discharge. At six months post discharge, nearly 90% of patients had consumed care, with approximately 20% related to COVID-19. This indicates a persisting need for rehabilitation post discharge from hospital in patients treated for COVID-19.", "doi": "10.1371/journal.pone.0291548", "pmid": "37708157", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10501636"}, {"db": "pii", "key": "PONE-D-23-18622"}], "notes": [], "created": "2023-10-06T06:52:58.476Z", "modified": "2023-10-06T10:43:03.121Z"}, {"entity": "publication", "iuid": "ac117d7f4cd745d5903004c4a12e5fef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac117d7f4cd745d5903004c4a12e5fef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac117d7f4cd745d5903004c4a12e5fef"}}, "title": "SARS-CoV-2-related mortality decrease in nursing home residents given multiple COVID-19 boosters.", "authors": [{"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Fj\u00e4llstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Moln\u00e1r", "given": "Christian", "initials": "C"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Vikstr\u00f6m", "given": "Linnea", "initials": "L"}, {"family": "Wigren-Bystr\u00f6m", "given": "Julia", "initials": "J"}, {"family": "Bennet", "given": "Louise", "initials": "L"}, {"family": "Widerstr\u00f6m", "given": "Micael", "initials": "M"}, {"family": "Rasmussen", "given": "Gunl\u00f6g", "initials": "G"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}], "type": "letter", "published": "2023-09-13", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/S1473-3099(23)00548-0", "pmid": "37716359", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(23)00548-0"}], "notes": [], "created": "2023-09-18T15:57:53.001Z", "modified": "2023-09-18T15:58:15.616Z"}, {"entity": "publication", "iuid": "160e70d0a33f483e8aa20c2ea5a59fd2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/160e70d0a33f483e8aa20c2ea5a59fd2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/160e70d0a33f483e8aa20c2ea5a59fd2"}}, "title": "Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.", "authors": [{"family": "Mihali\u010d", "given": "Filip", "initials": "F", "orcid": "0000-0002-6840-2319", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9750b70b9a374be18d94abbc82fa5bbc.json"}}, {"family": "Benz", "given": "Caroline", "initials": "C", "orcid": "0000-0002-5166-3598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13332514bfe7460db4a0f134718aa211.json"}}, {"family": "Kassa", "given": "Eszter", "initials": "E"}, {"family": "Lindqvist", "given": "Richard", "initials": "R"}, {"family": "Simonetti", "given": "Leandro", "initials": "L", "orcid": "0000-0003-1283-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9ef81e96c104878a6ccea620fc95400.json"}}, {"family": "Inturi", "given": "Raviteja", "initials": "R"}, {"family": "Aronsson", "given": "Hanna", "initials": "H"}, {"family": "Andersson", "given": "Eva", "initials": "E"}, {"family": "Chi", "given": "Celestine N", "initials": "CN"}, {"family": "Davey", "given": "Norman E", "initials": "NE"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK", "orcid": "0000-0001-6553-0940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9024ab251cf44bffbf3229ec909343af.json"}}, {"family": "Jemth", "given": "Per", "initials": "P", "orcid": "0000-0003-1516-7228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c5fe566cf5f44df9c98bb2b1d7078ba.json"}}, {"family": "Ivarsson", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-7081-3846", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b3cf0504a1b476f906c4b3e22b05d5a.json"}}], "type": "journal article", "published": "2023-09-13", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "14", "issue": "1", "pages": "5636"}, "abstract": "The virus life cycle depends on host-virus protein-protein interactions, which often involve a disordered protein region binding to a folded protein domain. Here, we used proteomic peptide phage display (ProP-PD) to identify peptides from the intrinsically disordered regions of the human proteome that bind to folded protein domains encoded by the SARS-CoV-2 genome. Eleven folded domains of SARS-CoV-2 proteins were found to bind 281 peptides from human proteins, and affinities of 31 interactions involving eight SARS-CoV-2 protein domains were determined (KD \u223c 7-300 \u03bcM). Key specificity residues of the peptides were established for six of the interactions. Two of the peptides, binding Nsp9 and Nsp16, respectively, inhibited viral replication. Our findings demonstrate how high-throughput peptide binding screens simultaneously identify potential host-virus interactions and peptides with antiviral properties. Furthermore, the high number of low-affinity interactions suggest that overexpression of viral proteins during infection may perturb multiple cellular pathways.", "doi": "10.1038/s41467-023-41312-8", "pmid": "37704626", "labels": {"Type: Journal article": null, "Category: Proteins": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10499821"}, {"db": "pii", "key": "10.1038/s41467-023-41312-8"}], "notes": [], "created": "2023-09-18T15:51:27.180Z", "modified": "2023-10-06T11:29:41.684Z"}, {"entity": "publication", "iuid": "0fd16b7d2ef24af1b02e8409dd48f602", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0fd16b7d2ef24af1b02e8409dd48f602.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0fd16b7d2ef24af1b02e8409dd48f602"}}, "title": "Identification of essential genes associated with SARS-CoV-2 infection as potential drug target candidates with machine learning algorithms.", "authors": [{"family": "Taheri", "given": "Golnaz", "initials": "G"}, {"family": "Habibi", "given": "Mahnaz", "initials": "M"}], "type": "journal article", "published": "2023-09-13", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "15141"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires the fast discovery of effective treatments to fight this worldwide concern. Several genes associated with the SARS-CoV-2, which are essential for its functionality, pathogenesis, and survival, have been identified. These genes, which play crucial roles in SARS-CoV-2 infection, are considered potential therapeutic targets. Developing drugs against these essential genes to inhibit their regular functions could be a good approach for COVID-19 treatment. Artificial intelligence and machine learning methods provide powerful infrastructures for interpreting and understanding the available data and can assist in finding fast explanations and cures. We propose a method to highlight the essential genes that play crucial roles in SARS-CoV-2 pathogenesis. For this purpose, we define eleven informative topological and biological features for the biological and PPI networks constructed on gene sets that correspond to COVID-19. Then, we use three different unsupervised learning algorithms with different approaches to rank the important genes with respect to our defined informative features. Finally, we present a set of 18 important genes related to COVID-19. Materials and implementations are available at: https://github.com/MahnazHabibi/Gene_analysis .", "doi": "10.1038/s41598-023-42127-9", "pmid": "37704748", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Genomics & transcriptomics": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC10499814"}, {"db": "pii", "key": "10.1038/s41598-023-42127-9"}], "notes": [], "created": "2023-10-06T06:52:11.207Z", "modified": "2023-10-06T08:24:45.259Z"}, {"entity": "publication", "iuid": "ee8a417d0c014b54b315229da0a7672b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee8a417d0c014b54b315229da0a7672b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee8a417d0c014b54b315229da0a7672b"}}, "title": "Psychological distress and musculoskeletal pain in manual therapists during the second wave of the COVID-19 pandemic in Sweden: a cross-sectional study.", "authors": [{"family": "Weiss", "given": "Nathan", "initials": "N", "orcid": "0000-0002-1814-020X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd09b882d55a45d78c868e6fd116d660.json"}}, {"family": "Skillgate", "given": "Eva", "initials": "E"}, {"family": "Ax\u00e9n", "given": "Iben", "initials": "I"}], "type": "journal article", "published": "2023-09-12", "journal": {"title": "Chiropr Man Therap", "issn": "2045-709X", "issn-l": "2045-709X", "volume": "31", "issue": "1", "pages": "34"}, "abstract": "The COVID-19 pandemic had an unprecedented impact on healthcare, and the health of healthcare workers has been subject of much research. However, studies of health-related factors in manual therapists during the COVID-19 pandemic are scarce. Research in this field can provide valuable insights for future crises policy and guidelines, including in regions where the public health response to COVID-19 contrasts with that of most other international jurisdictions. The aim was to describe the prevalence of psychological distress and musculoskeletal pain, and to investigate factors potentially associated with high psychological distress and activity-limiting musculoskeletal pain in clinically active chiropractors and naprapaths during the second wave of the COVID-19 pandemic in Sweden.\r\n\r\nA cross-sectional survey was distributed to a representative sample of Swedish manual therapists, between November 2020 and January 2021. High psychological distress and activity-limiting musculoskeletal pain were investigated regarding associations with residing in a municipality with a high spread of infection, a previous/ongoing SARS-CoV-2 infection, clinical interferences and economic consequences associated with the pandemic. Generalized Linear Models with log link and binomial distribution were used, computing prevalence ratios (PR) with 95% confidence intervals (95% CI).\r\n\r\nA total of 762 participants were included, representing 46% of the source population. The prevalence of depressive, anxiety, and stress symptoms was 17%, 7%, and 12%, respectively. Neck (50%), low back (46%), upper back (40%), and shoulders (39%) were the most prevalent musculoskeletal pain areas. Economic consequences due to the pandemic were associated with high psychological distress (PR = 2.30, 95% CI: 1.48-3.53).\r\n\r\nDuring the second wave of the COVID-19 pandemic in Sweden, manual therapists primarily suffered from musculoskeletal pain related to the back and shoulders, while depressive symptoms were the most common symptom of psychological distress. Owners of businesses that suffered economic consequences had a higher prevalence of high psychological distress, which may call for targeted support of this group in future similar contexts. Future longitudinal studies during the pandemic are warranted to assess these associations further.", "doi": "10.1186/s12998-023-00511-2", "pmid": "37700309", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10498599"}, {"db": "pii", "key": "10.1186/s12998-023-00511-2"}], "notes": [], "created": "2023-10-06T06:52:30.019Z", "modified": "2023-10-06T09:41:12.833Z"}, {"entity": "publication", "iuid": "4e51eab6d2f54fce8ef5f19b576cf214", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4e51eab6d2f54fce8ef5f19b576cf214.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4e51eab6d2f54fce8ef5f19b576cf214"}}, "title": "Comparative effectiveness of mRNA-1273 and BNT162b2 COVID-19 vaccines in immunocompromised individuals: a systematic review and meta-analysis using the GRADE framework.", "authors": [{"family": "Wang", "given": "Xuan", "initials": "X"}, {"family": "Haeussler", "given": "Katrin", "initials": "K"}, {"family": "Spellman", "given": "Anne", "initials": "A"}, {"family": "Phillips", "given": "Leslie E", "initials": "LE"}, {"family": "Ramiller", "given": "Allison", "initials": "A"}, {"family": "Bausch-Jurken", "given": "Mary T", "initials": "MT"}, {"family": "Sharma", "given": "Pawana", "initials": "P"}, {"family": "Krivelyova", "given": "Anna", "initials": "A"}, {"family": "Vats", "given": "Sonam", "initials": "S"}, {"family": "Van de Velde", "given": "Nicolas", "initials": "N"}], "type": "meta-analysis", "published": "2023-09-12", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "1204831"}, "abstract": "Despite representing only 3% of the US population, immunocompromised (IC) individuals account for nearly half of the COVID-19 breakthrough hospitalizations. IC individuals generate a lower immune response after vaccination in general, and the US CDC recommended a third dose of either mRNA-1273 or BNT162b2 COVID-19 vaccines as part of their primary series. Influenza vaccine trials have shown that increasing dosage could improve effectiveness in IC populations. The objective of this systematic literature review and pairwise meta-analysis was to evaluate the clinical effectiveness of mRNA-1273 (50 or 100 mcg/dose) vs BNT162b2 (30 mcg/dose) in IC populations using the GRADE framework.\r\n\r\nThe systematic literature search was conducted in the World Health Organization COVID-19 Research Database. Studies were included in the pairwise meta-analysis if they reported comparisons of mRNA-1273 and BNT162b2 in IC individuals \u226518 years of age; outcomes of interest were symptomatic, laboratory-confirmed SARS-CoV-2 infection, SARS-CoV-2 infection, severe SARS-CoV-2 infection, hospitalization due to COVID-19, and mortality due to COVID-19. Risk ratios (RR) were pooled across studies using random-effects meta-analysis models. Outcomes were also analyzed in subgroups of patients with cancer, autoimmune disease, and solid organ transplant. Risk of bias was assessed using the Newcastle-Ottawa Scale for observational studies. Evidence was evaluated using the GRADE framework.\r\n\r\nOverall, 17 studies were included in the pairwise meta-analysis. Compared with BNT162b2, mRNA-1273 was associated with significantly reduced risk of SARS-CoV-2 infection (RR, 0.85 [95% CI, 0.75-0.97]; P=0.0151; I67.7%), severe SARS-CoV-2 infection (RR, 0.85 [95% CI, 0.77-0.93]; 2 = P=0.0009; I0%), COVID-19-associated hospitalization (RR, 0.88 [95% CI, 0.79-0.97]; 2 = P<0.0001; I0%), and COVID-19-associated mortality (RR, 0.63 [95% CI, 0.44-0.90]; 2 = P=0.0119; I0%) in IC populations. Results were consistent across subgroups. Because of sample size limitations, relative effectiveness of COVID-19 mRNA vaccines in IC populations cannot be studied in randomized trials. Based on nonrandomized studies, evidence certainty among comparisons was type 3 (low) and 4 (very low), reflecting potential biases in observational studies.2 =\r\n\r\nThis GRADE meta-analysis based on a large number of consistent observational studies showed that the mRNA-1273 COVID-19 vaccine is associated with improved clinical effectiveness in IC populations compared with BNT162b2.", "doi": "10.3389/fimmu.2023.1204831", "pmid": "37771594", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10523015"}], "notes": [], "created": "2023-10-06T06:52:18.225Z", "modified": "2023-10-06T08:46:46.071Z"}, {"entity": "publication", "iuid": "f707cac0c9ec4fc6b4115fc65fd5538d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f707cac0c9ec4fc6b4115fc65fd5538d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f707cac0c9ec4fc6b4115fc65fd5538d"}}, "title": "COVID-19 outcomes in patients with a history of immune-mediated glomerular diseases.", "authors": [{"family": "Gauckler", "given": "Philipp", "initials": "P"}, {"family": "Kesenheimer", "given": "Jana S", "initials": "JS"}, {"family": "Geetha", "given": "Duvuru", "initials": "D"}, {"family": "Odler", "given": "Balazs", "initials": "B"}, {"family": "Eller", "given": "Kathrin", "initials": "K"}, {"family": "Laboux", "given": "Timothee", "initials": "T"}, {"family": "Alberici", "given": "Federico", "initials": "F"}, {"family": "Zappa", "given": "Mattia", "initials": "M"}, {"family": "Chebotareva", "given": "Natasha", "initials": "N"}, {"family": "Moiseev", "given": "Sergey", "initials": "S"}, {"family": "Bonilla", "given": "Marco", "initials": "M"}, {"family": "Jhaveri", "given": "Kenar D", "initials": "KD"}, {"family": "Oniszczuk", "given": "Julie", "initials": "J"}, {"family": "Audard", "given": "Vincent", "initials": "V"}, {"family": "Costa", "given": "Denise", "initials": "D"}, {"family": "Mastroianni-Kirsztajn", "given": "Gianna", "initials": "G"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Muto", "given": "Masahiro", "initials": "M"}, {"family": "Windpessl", "given": "Martin", "initials": "M"}, {"family": "Mayer", "given": "Gert", "initials": "G"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2023-09-12", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "1228457"}, "abstract": "Patients with immune-mediated glomerular diseases are considered at high risk for severe COVID-19 outcomes. However, conclusive evidence for this patient population is scarce.\r\n\r\nWe created a global registry and retrospectively collected clinical data of patients with COVID-19 and a previously diagnosed immune-mediated glomerular disease to characterize specific risk factors for severe COVID-19 outcomes.\r\n\r\nFifty-nine patients with a history of immune-mediated glomerular diseases were diagnosed with COVID-19 between 01.03.2020 and 31.08.2021. Over a mean follow-up period of 24.79 \u00b1 18.89 days, ten patients (16.9%) developed acute kidney injury. Overall, 44.1% of patients were managed in an outpatient setting and therefore considered as having \"non-severe\" COVID-19, while 55.9% of patients had severe COVID-19 requiring hospitalization including worse outcomes. Comparing both groups, patients with severe COVID-19 were significantly older (53.55 \u00b1 17.91 versus 39.77 \u00b1 14.95 years, p = .003), had lower serum albumin levels at presentation (3.00 \u00b1 0.80 g/dL versus 3.99 \u00b1 0.68 g/dL, p = .016) and had a higher risk of developing acute kidney injury (27% versus 4%, p = .018). Male sex (p <.001) and ongoing intake of corticosteroids at presentation (p = .047) were also significantly associated with severe COVID-19 outcomes, while the overall use of ongoing immunosuppressive agents and glomerular disease remission status showed no significant association with the severity of COVID-19 (p = .430 and p = .326, respectively).\r\n\r\nOlder age, male sex, ongoing intake of corticosteroids and lower serum albumin levels at presentation were identified as risk factors for severe COVID-19 outcomes in patients with a history of various immune-mediated glomerular diseases.", "doi": "10.3389/fimmu.2023.1228457", "pmid": "37767096", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10520971"}], "notes": [], "created": "2023-10-06T06:55:31.187Z", "modified": "2023-10-06T10:56:25.611Z"}, {"entity": "publication", "iuid": "fde482edb3254b7aa40775042bfddfbf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fde482edb3254b7aa40775042bfddfbf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fde482edb3254b7aa40775042bfddfbf"}}, "title": "Type 1 diabetes, COVID-19 vaccines and short-term safety: Subgroup analysis from the global COVAD study.", "authors": [{"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Ravichandran", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Nair", "given": "Narmadha", "initials": "N"}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Barman", "given": "Bhupen", "initials": "B", "orcid": "0000-0002-5433-1310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7747785ec5fa4743bc70bd20fbca10fd.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Saha", "given": "Sreoshy", "initials": "S", "orcid": "0000-0001-6745-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00238845dd4833ae51ffb75e2fe144.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Pande", "given": "Arun Kumar R", "initials": "AKR", "orcid": "0000-0002-9570-1509", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ffc8a0aa37c14dffb457a50cd61740d5.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Boro", "given": "Hiya", "initials": "H"}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "COVAD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-09-11", "journal": {"title": "J Diabetes Investig", "issn": "2040-1124", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Coronavirus disease 2019 (COVID-19) vaccinations have been proven to be generally safe in healthy populations. However, the data on vaccine safety in patients with type 1 diabetes are scarce. This study aimed to evaluate the frequency and severity of short-term (<7-day) adverse vaccination events (AEs) and their risk factors among type 1 diabetes patients.\r\n\r\nThis study analyzed data from the COVID-19 vaccination in Autoimmune Diseases (COVAD) survey database (May to December 2021; 110 collaborators, 94 countries), comparing <7-day COVID-19 vaccine AE among type 1 diabetes patients and healthy controls (HCs). Descriptive statistics; propensity score matching (1:4) using the variables age, sex and ethnicity; and multivariate analyses were carried out.\r\n\r\nThis study analyzed 5,480 completed survey responses. Of all responses, 5,408 were HCs, 72 were type 1 diabetes patients (43 females, 48.0% white European ancestry) and Pfizer was the most administered vaccine (39%). A total of 4,052 (73.9%) respondents had received two vaccine doses. Patients with type 1 diabetes had a comparable risk of injection site pain, minor and major vaccine AEs, as well as associated hospitalizations to HCs. However, type 1 diabetes patients had a higher risk of severe rashes (3% vs 0.4%, OR 8.0, 95% confidence interval 1.7-36), P = 0.007), although reassuringly, these were rare (n = 2 among type 1 diabetes patients).\r\n\r\nCOVID-19 vaccination was safe and well tolerated in patients with type 1 diabetes with similar AE profiles compared with HCs, although severe rashes were more common in type 1 diabetes patients.", "doi": "10.1111/jdi.14079", "pmid": "37697820", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:56:49.199Z", "modified": "2023-10-06T11:30:56.100Z"}, {"entity": "publication", "iuid": "6eb4985c19994970802917859c7bf524", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6eb4985c19994970802917859c7bf524.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6eb4985c19994970802917859c7bf524"}}, "title": "Gambling helpline contacts during COVID-19-related availability restrictions: an interrupted time series analysis.", "authors": [{"family": "Wall", "given": "H", "initials": "H"}, {"family": "Kristiansen", "given": "S", "initials": "S"}, {"family": "Molander", "given": "O", "initials": "O"}, {"family": "Forsstr\u00f6m", "given": "D", "initials": "D"}, {"family": "Marionneau", "given": "V", "initials": "V"}], "type": "journal article", "published": "2023-09-09", "journal": {"title": "Public Health", "issn": "1476-5616", "issn-l": null, "volume": "224", "issue": null, "pages": "14-19"}, "abstract": "Gambling causes significant public health harms that are addressed in the help service network. Helplines are the most widely used service among those experiencing harms. The COVID-19 pandemic changed the global gambling landscape. This study assesses the effect of COVID-19-related restrictions on help-seeking for gambling via helplines.\r\n\r\nWe analysed data of national helplines in Sweden, Finland, and Denmark before and during the pandemic. The countries differed in their restrictions on the availability and accessibility of gambling during the pandemic.\r\n\r\nWe performed an interrupted time series analysis of contact and web traffic data to helplines in Sweden, Finland, and Denmark before and during the COVID-19 pandemic (2017-2021). We also compared forecasted time series to the actual data to assess change.\r\n\r\nThe results show diverging patterns across the three countries. In Sweden, the number of helpline contacts remained stable throughout COVID-19, but there was an increasing trend in website visits. In Finland, the number of contacts declined during the first wave but rebounded during the second wave. Website visitation increased moderately. In Denmark, the number of contacts to the helpline soared over the COVID-19 period.\r\n\r\nThe diverging results suggest that help-seeking behaviour is likely to be impacted by differing policy approaches to gambling availability and limit-setting, visibility of helplines, and the prevalence of different forms of gambling in the three Nordic countries before and during the pandemic. This has implications for a preventive public health approach for gambling.", "doi": "10.1016/j.puhe.2023.08.013", "pmid": "37696197", "labels": {"Type: Journal article": null, "Funder: Forte": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0033-3506(23)00296-2"}], "notes": [], "created": "2023-10-06T06:55:19.376Z", "modified": "2023-10-06T10:50:22.910Z"}, {"entity": "publication", "iuid": "3a916267a8004d29a0603ec71f47c07f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a916267a8004d29a0603ec71f47c07f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a916267a8004d29a0603ec71f47c07f"}}, "title": "Antibiotic prescriptions among dentists across Norway and the impact of COVID-19 pandemic.", "authors": [{"family": "Tousi", "given": "Farnoush", "initials": "F"}, {"family": "Al Haroni", "given": "Mohammed", "initials": "M"}, {"family": "Lie", "given": "Stein Atle", "initials": "SA"}, {"family": "Lund", "given": "Bodil", "initials": "B"}], "type": "journal article", "published": "2023-09-08", "journal": {"title": "BMC Oral Health", "issn": "1472-6831", "issn-l": null, "volume": "23", "issue": "1", "pages": "649"}, "abstract": "The prescription of antibiotics in dental practice contributes significantly to the total use of antibiotics in primary healthcare. This study aimed to evaluate antibiotic prescription in dental practice during the years 2016-2021 in Norway and their relative contribution to national outpatient consumption and to investigate the influence of age, gender, geographic region, and COVID-19. A further aim was to review differences in prescribing patterns to verify effect of governmental strategies to reduce over-prescribing of antibiotics.\r\n\r\nThis register study investigated the national antibiotic prescription between 2016 and 2021. Data was obtained from the Norwegian prescription register, the Norwegian Institute of Public Health and Statistics Norway. The consumption of 12 common antibiotics was measured using WHO defined daily doses (DDDs), DDD per 1000 inhabitants per day (DIDs 1000).\r\n\r\nA total of 6,049,445 antibiotic prescriptions of the 12 investigated compounds were issued in primary care during the study period. Dentists accounted for 942,350 prescriptions corresponding to 15.6% of the total. An overall decrease in the number of prescriptions by health professions other than dentists during the 5 years (IRR = 0.92, 95% CI:0.92-0.93, p < 0.001) was observed. For dentists a slight increase in the number of prescriptions (IRR = 1.01, 95% CI: 1.01-1.01, p < 0.001) was seen over the study period. The increase of antibiotic prescriptions in dentistry was more pronounced during the COVID-19 pandemic. The 4 most prescribed type of antibiotics based on average number of DDDs of the total period 2016-2021 were in descending order; phenoxymethylpenicillin (1,109,150) followed by amoxicillin (126,244), clindamycin (72,565), and metronidazole (64,599). An unexpected finding was that the prescription of the combination compound amoxicillin/clavulanic acid had significantly increased in dentistry during the last 5 years. Geographic, gender, and age differences in the rates of prescriptions were also seen. The data revealed that there are seasonal variations in dental prescriptions.\r\n\r\nNoticeable differences exist in prescribing patterns of antibiotics in the last 5 years. Restricted access to dental care due to COVID-19 may have resulted in increased antibiotic prescribing in dentistry as opposed to an otherwise downward trend. Despite national guidelines there is still a need for improvement of antibiotic stewardship in dentistry and to define effective methods to disseminate information.", "doi": "10.1186/s12903-023-03380-6", "pmid": "37684614", "labels": {"Category: Health": null, "Type: Journal article": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC10492408"}, {"db": "pii", "key": "10.1186/s12903-023-03380-6"}], "notes": [], "created": "2023-10-06T06:56:54.348Z", "modified": "2023-10-06T11:33:08.611Z"}, {"entity": "publication", "iuid": "c33bb0bd2b7a40c2a1086b25f36e79fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c33bb0bd2b7a40c2a1086b25f36e79fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c33bb0bd2b7a40c2a1086b25f36e79fd"}}, "title": "Perceptions of everyday life during lenient COVID-19 restrictions in Sweden- an interview study.", "authors": [{"family": "Lindgren", "given": "Ingrid", "initials": "I"}, {"family": "Trulsson Schouenborg", "given": "Anna", "initials": "A"}, {"family": "Larsson", "given": "Caroline", "initials": "C"}, {"family": "Stigmar", "given": "Kjerstin", "initials": "K"}], "type": "journal article", "published": "2023-09-07", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "23", "issue": "1", "pages": "1743"}, "abstract": "Both COVID-19 and its associated societal restrictions have affected individuals' health and everyday life. In Sweden, more lenient public health restrictions were implemented, with individuals asked to act responsibly in terms of reducing spread of disease. The majority of studies reporting on experiences of Covid-19 restrictions have been in the context of more substantial mandatory rules aimed at reducing social contact, therefore it is important to describe how more lenient restrictions have impacted individuals' well-being. This study aims to describe perceptions of everyday life during the first wave of the COVID-19 pandemic, perceived by individuals with no underlying medical condition, and living with more lenient public health restrictions in Sweden.\r\n\r\nThe participants were recruited from individuals who originally had participated in an online survey about life satisfaction, health, and physical activity. Fifteen individuals (median age 49, range 26-76 years, seven women) in various social situations, such as living alone/cohabiting, having children at home, geographical area and size of city were interviewed. Qualitative content analysis was applied to the data.\r\n\r\nAn overall theme \"Both hindrances and opportunities in important life domains were experienced within the same person during lenient Covid-19 restrictions\" was derived and covered three categories: \"New possibilities of flexibility in work and better health\", \"Life went on as usual with minor adjustments\" and \"Everyday life changed and became more difficult\" together with eight subcategories. For most participants, both facilitating and hindering important domains in life were described. Unexpected findings were positive experiences regarding working from home, physical activities, leisure time activities and the balance between work and leisure time. In areas where only minor adjustments were made, life was perceived as going on as before. On the other hand, restrictions increased worries and were perceived to have negative effects on social participation.\r\n\r\nThe impact of the pandemic and lenient restrictions in Sweden on the participants\u00b4 everyday life was multifaceted. Both hindrances and opportunities in important life domains were experienced within the same person. An increased flexibility in work- and leisure activities were perceived having positive effects for health and wellbeing and led to a better balance in life.", "doi": "10.1186/s12889-023-16599-3", "pmid": "37679662", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10483720"}, {"db": "pii", "key": "10.1186/s12889-023-16599-3"}], "notes": [], "created": "2023-10-06T06:56:17.554Z", "modified": "2023-10-06T11:15:12.699Z"}, {"entity": "publication", "iuid": "e4a3cefb49924dd39e8d1ba6dba2ed68", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e4a3cefb49924dd39e8d1ba6dba2ed68.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e4a3cefb49924dd39e8d1ba6dba2ed68"}}, "title": "COVID-19 pandemic hits differently: examining its consequences for women's livelihoods and healthcare access - a cross-sectional study in Kinshasa DRC.", "authors": [{"family": "Nkweleko Fankam", "given": "Falone", "initials": "F", "orcid": "0000-0001-7826-9382", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f15dd40fbc11449a8b1ab7fda57ae276.json"}}, {"family": "Ugarte", "given": "William", "initials": "W"}, {"family": "Akilimali", "given": "Pierre", "initials": "P"}, {"family": "Ewane Etah", "given": "Junior", "initials": "J"}, {"family": "\u00c5kerman", "given": "Eva", "initials": "E"}], "type": "journal article", "published": "2023-09-07", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "9", "pages": "e072869"}, "abstract": "The emergence of the COVID-19 pandemic led to multiple preventive actions as primary interventions to contain the spread of the virus. Globally, countries are facing enormous challenges with consequences for use of social, economic and health services. The Democratic Republic of Congo (DRC) was among the African countries implementing strict lockdown at the start of the pandemic, resulting in shortages and decreased access to services. The adverse effects of the pandemic had unpleasant consequences for the country. This study aimed to examine the association between COVID-19 pandemic-related factors, sociodemographic factors, and the need to visit healthcare facilities, including family planning services, among women aged 15-49 years in the DRC.\r\n\r\nWe conducted a secondary analysis of a performance monitoring for action (PMA) cross-sectional COVID-19 phone survey in Kinshasa, DRC, which had a response rate of 74.7%. In total, 1325 randomly selected women aged 15-49 years from the Kinshasa province who had previously participated in the PMA baseline survey participated in the survey. Bivariate and multivariate logistic regressions were used to assess associations.\r\n\r\nThe COVID-19 pandemic and related factors affected 92% of women in the Kinshasa province socioeconomically. A majority were highly economically dependent on their partner or some other sources for their basic needs to be met, and even more worried about the future impact of the pandemic on their household finances. Over 50% of women did not attempt visiting a health service, with some of the top reasons being fear of being infected with COVID-19 and not being able to afford services. We found a significant association between age groups and contraceptive use. The need for and use of contraceptives was higher among women aged 25-34 years than those aged 15-24 or 35-49 years.\r\n\r\nEffective social/economic support to women and girls during pandemics and in crises is essential as it can have lasting beneficial effects on many domains of their lives, including their ability to access health services and the contraceptives of their choice.", "doi": "10.1136/bmjopen-2023-072869", "pmid": "37678942", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10496687"}, {"db": "pii", "key": "bmjopen-2023-072869"}], "notes": [], "created": "2023-10-06T06:56:09.388Z", "modified": "2023-10-06T11:06:05.953Z"}, {"entity": "publication", "iuid": "6f160d0571b7441db235a4a6aa93b071", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f160d0571b7441db235a4a6aa93b071.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f160d0571b7441db235a4a6aa93b071"}}, "title": "Fresh or frozen grafts for allogeneic stem cell transplantation: conceptual considerations and a survey on the practice during the COVID-19 pandemic from the EBMT Infectious Diseases Working Party (IDWP) and Cellular Therapy & Immunobiology Working Party (CTIWP).", "authors": [{"family": "Worel", "given": "N", "initials": "N", "orcid": "0000-0002-3599-8099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0dc334f4e434fb7b018f43f56d9135c.json"}}, {"family": "Ljungman", "given": "P", "initials": "P", "orcid": "0000-0002-8281-3245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4546eb504184683ab712eee858ea9cb.json"}}, {"family": "Verheggen", "given": "I C M", "initials": "ICM"}, {"family": "Hoogenboom", "given": "J D", "initials": "JD"}, {"family": "Knelange", "given": "N S", "initials": "NS"}, {"family": "Eikema", "given": "D-J", "initials": "D"}, {"family": "S\u00e1nchez-Ortega", "given": "I", "initials": "I"}, {"family": "Riillo", "given": "C", "initials": "C"}, {"family": "Centorrino", "given": "I", "initials": "I"}, {"family": "Averbuch", "given": "D", "initials": "D", "orcid": "0000-0001-9614-7274", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/161ea7304f3046d1926a0b58ff122c98.json"}}, {"family": "Chabannon", "given": "C", "initials": "C", "orcid": "0000-0002-3755-4889", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6383ab718ee423da23a515b971751bc.json"}}, {"family": "de la Camara", "given": "R", "initials": "R", "orcid": "0000-0002-8189-5779", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/868bc0284ac640a1bf215e7d7cc86da3.json"}}, {"family": "Kuball", "given": "J", "initials": "J", "orcid": "0000-0002-3914-7806", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93b68b37f90949f681e03905510def84.json"}}, {"family": "Ruggeri", "given": "A", "initials": "A", "orcid": "0000-0002-7261-2765", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22584a74a4864481acc0ef4c17f12fc7.json"}}], "type": "journal article", "published": "2023-09-06", "journal": {"title": "Bone Marrow Transplant", "issn": "1476-5365", "issn-l": "0268-3369", "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic has had a significant impact on medical practices, including the delivery of allogeneic hematopoietic cell transplantation (HCT). In response, transplant centers have made changes to their procedures, including an increased use of cryopreservation for allogeneic haematopoietic progenitor cell (HPC) grafts. The use of cryopreserved grafts for allogeneic HCT has been reviewed and analysed in terms of potential benefits and drawbacks based on existing data on impact on cell subsets, hematological recovery, and clinical outcomes of approximately 2000 patients from different studies. A survey of European Society for Blood and Marrow Transplantation centers was also conducted to assess changes in practice during the pandemic and any unnecessary burdens on HPC donors. Before the pandemic, only 7.4% of transplant centers were routinely cryopreserving HPC products, but this percentage increased to 90% during the pandemic. The results of this review and survey suggest that cryopreservation of HPC grafts is a viable option for allogeneic HCT in certain situations, but further research is needed to determine long-term effects and ethical discussions are required to balance the needs of donors and patients when using frozen allografts.", "doi": "10.1038/s41409-023-02099-w", "pmid": "37673982", "labels": {"Type: Review": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41409-023-02099-w"}], "notes": [], "created": "2023-10-06T06:57:23.413Z", "modified": "2023-10-06T11:43:35.176Z"}, {"entity": "publication", "iuid": "46bc6c34a2ab4384b9c54c5e48b65926", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46bc6c34a2ab4384b9c54c5e48b65926.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46bc6c34a2ab4384b9c54c5e48b65926"}}, "title": "The Use of High-Flow Nasal Cannula and Non-Invasive Mechanical Ventilation in the Management of COVID-19 Patients: A Prospective Study.", "authors": [{"family": "Arunachala", "given": "Sumalatha", "initials": "S", "orcid": "0000-0001-5858-8298", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec761000c8c1429ba3459dcd08529abf.json"}}, {"family": "Parthasarathi", "given": "Ashwaghosha", "initials": "A", "orcid": "0000-0002-7270-0247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c0a5e6837a421cbbb0314628ae7f24.json"}}, {"family": "Basavaraj", "given": "Chetak Kadabasal", "initials": "CK", "orcid": "0000-0002-7422-8353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dea3044d43fb4b648b46945d7cb39367.json"}}, {"family": "Malamardi", "given": "Sowmya", "initials": "S"}, {"family": "Chandran", "given": "Shreya", "initials": "S"}, {"family": "Venkataraman", "given": "Hariharan", "initials": "H"}, {"family": "Ullah", "given": "Mohammed Kaleem", "initials": "MK", "orcid": "0000-0001-8470-3114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1645033dc8e84aa493a444301f0403ad.json"}}, {"family": "Ganguly", "given": "Koustav", "initials": "K", "orcid": "0000-0001-8531-8154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58b2e0d7853a4b32920e54042e95061d.json"}}, {"family": "Upadhyay", "given": "Swapna", "initials": "S", "orcid": "0000-0003-4699-4082", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c98621d4161241dd9379dca3fa6e1bf1.json"}}, {"family": "Mahesh", "given": "Padukudru Anand", "initials": "PA", "orcid": "0000-0003-1632-5945", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70c3b10ccc334c4c8195556f07c862d0.json"}}], "type": "journal article", "published": "2023-09-05", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "15", "issue": "9", "issn-l": "1999-4915"}, "abstract": "High-flow nasal cannula (HFNC) and ventilator-delivered non-invasive mechanical ventilation (NIV) were used to treat acute respiratory distress syndrome (ARDS) due to COVID-19 pneumonia, especially in low- and middle-income countries (LMICs), due to lack of ventilators and manpower resources despite the paucity of data regarding their efficacy. This prospective study aimed to analyse the efficacy of HFNC versus NIV in the management of COVID-19 ARDS. A total of 88 RT-PCR-confirmed COVID-19 patients with moderate ARDS were recruited. Linear regression and generalized estimating equations (GEEs) were used for trends in vital parameters over time. A total of 37 patients were on HFNC, and 51 were on NIV. Patients in the HFNC group stayed slightly but not significantly longer in the ICU as compared to their NIV counterparts (HFNC vs. NIV: 8.00 (4.0-12.0) days vs. 7.00 (2.0-12.0) days; p = 0.055). Intubation rates, complications, and mortality were similar in both groups. The switch to HFNC from NIV was 5.8%, while 37.8% required a switch to NIV from HFNC. The resolution of respiratory alkalosis was better with NIV. We conclude that in patients with COVID-19 pneumonia with moderate ARDS, the duration of treatment in the ICU, intubation rate, and mortality did not differ significantly with the use of HFNC or NIV for respiratory support.", "doi": "10.3390/v15091879", "pmid": "37766286", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10535869"}, {"db": "pii", "key": "v15091879"}], "notes": [], "created": "2023-10-06T06:56:33.827Z", "modified": "2023-10-06T06:56:33.999Z"}, {"entity": "publication", "iuid": "db4ad85eac5d4bbe840da6bfb6a0e847", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db4ad85eac5d4bbe840da6bfb6a0e847.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db4ad85eac5d4bbe840da6bfb6a0e847"}}, "title": "Optimal age-specific vaccination control for COVID-19: An Irish case study.", "authors": [{"family": "Zavrakli", "given": "Eleni", "initials": "E", "orcid": "0000-0002-4866-5525", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d1bfa1f3bdd4c7a92e98d2abfe3a7d7.json"}}, {"family": "Parnell", "given": "Andrew", "initials": "A"}, {"family": "Malone", "given": "David", "initials": "D"}, {"family": "Duffy", "given": "Ken", "initials": "K"}, {"family": "Dey", "given": "Subhrakanti", "initials": "S"}], "type": "journal article", "published": "2023-09-05", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "9", "pages": "e0290974"}, "abstract": "The outbreak of a novel coronavirus causing severe acute respiratory syndrome in December 2019 has escalated into a worldwide pandemic. In this work, we propose a compartmental model to describe the dynamics of transmission of infection and use it to obtain the optimal vaccination control. The model accounts for the various stages of the vaccination, and the optimisation is focused on minimising the infections to protect the population and relieve the healthcare system. As a case study, we selected the Republic of Ireland. We use data provided by Ireland's COVID-19 Data-Hub and simulate the evolution of the pandemic with and without the vaccination in place for two different scenarios, one representative of a national lockdown situation and the other indicating looser restrictions in place. One of the main findings of our work is that the optimal approach would involve a vaccination programme where the older population is vaccinated in larger numbers earlier while simultaneously part of the younger population also gets vaccinated to lower the risk of transmission between groups. We compare our simulated results with those of the vaccination policy taken by the Irish government to explore the advantages of our optimisation method. Our comparison suggests that a similar reduction in cases may have been possible even with a reduced set of vaccinations available for use.", "doi": "10.1371/journal.pone.0290974", "pmid": "37669287", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Funder: H2020": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10479919"}, {"db": "pii", "key": "PONE-D-22-29430"}], "notes": [], "created": "2023-10-06T06:57:18.381Z", "modified": "2023-10-09T06:07:48.549Z"}, {"entity": "publication", "iuid": "563c15a9d6e84ace98f3e59d19dc6398", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/563c15a9d6e84ace98f3e59d19dc6398.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/563c15a9d6e84ace98f3e59d19dc6398"}}, "title": "Management of complications after skin surgery relevant for melanoma in the trunk and extremities during the COVID-19 pandemic: a case series report.", "authors": [{"family": "Huang", "given": "Yinglai", "initials": "Y"}, {"family": "Carlsson", "given": "Lena", "initials": "L"}, {"family": "Jogeland", "given": "Karin", "initials": "K"}, {"family": "Samuelsson", "given": "Marianne", "initials": "M"}, {"family": "Larsson", "given": "Lars", "initials": "L"}, {"family": "Jonsborg", "given": "Catarina", "initials": "C"}], "type": "case reports", "published": "2023-09-05", "journal": {"title": "World J Surg Oncol", "issn": "1477-7819", "issn-l": null, "volume": "21", "issue": "1", "pages": "280"}, "abstract": "Patients with melanoma have been found to be at greater risk of adverse outcomes including mortality after contacting COVID-19. Management of postsurgical complications presented additional challenges by potentially increasing exposure to COVID-19 through repeated inpatient admissions to hospital during the pandemic. We report four cases for which skin flaps, lymph ligation, and split-thickness skin graft (STSG) were successfully used in the treatment of complications in the trunk and extremities after wide local excision (WLE). This study details the operative experience in management of postsurgical complications for melanoma in the trunk and extremities during a 6-month period at the height of the COVID-19 pandemic.\r\n\r\nWe present 4 cases detailing management of complications that occurred after wide local excisions performed for melanoma during Feb. to Oct. 2020. Case 1: A 90-year-old man who experienced wound dehiscence and necrosis on the shoulder after non-radical excision for an aggressive melanoma and underwent the side-to-side closure after ellipse formed WLE with modified tangent-to-circle method. Case 2: An 80-year-old man who had undergone excision for melanoma in his left upper arm and histopathology did not show radically. Two weeks after the excision, he underwent a WLE and direct reconstruction with double rotation skin flap. Case 3: A 55-year-old man that experienced a large wound dehiscence on his back due to WLE. He underwent an advanced double skin flap operation. Case 4: A 36-year-old woman who had a lymphorrhea and graft necrosis after WLE and STSG on the right lower leg. A combination of micro lymph ligation and re-STSG was performed. One month after the operation, all wounds had healed. There was no clinical evidence of tumor recurrence after 8 months post procedure.\r\n\r\nSevere complications (e.g., large wound dehiscence, necrosis, or lymphorrhea) following wide local excision of melanoma are infrequent but must be swiftly and appropriately managed, especially during the COVID-19 pandemic to decrease the likelihood of COVID-19 infection and impaired oncology outcomes from delaying systemic cancer therapy due to the complications in primary interventions.", "doi": "10.1186/s12957-023-03084-9", "pmid": "37670317", "labels": {"Category: Health": null, "Category: Other": null, "Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10478401"}, {"db": "pii", "key": "10.1186/s12957-023-03084-9"}], "notes": [], "created": "2023-10-06T06:55:28.836Z", "modified": "2023-10-06T10:54:51.343Z"}, {"entity": "publication", "iuid": "968804a2c4004313b96cfa43ab3c7ea8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/968804a2c4004313b96cfa43ab3c7ea8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/968804a2c4004313b96cfa43ab3c7ea8"}}, "title": "End-of-life decision-making in critically ill old patients with and without coronavirus disease 2019.", "authors": [{"family": "Syrous", "given": "Alma Nordenskj\u00f6ld", "initials": "AN", "orcid": "0000-0002-8599-204X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e76d014cdc440b5ba8dc33aa7583db9.json"}}, {"family": "Gudnadottir", "given": "Gudny", "initials": "G"}, {"family": "Oras", "given": "Jonatan", "initials": "J", "orcid": "0000-0001-8890-6752", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bcac0f5ee544c18ba18e949ce76d121.json"}}, {"family": "Ferguson", "given": "Thalia", "initials": "T"}, {"family": "Lilja", "given": "David", "initials": "D"}, {"family": "Odenstedt Herges", "given": "Helena", "initials": "H", "orcid": "0000-0002-5146-0205", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10c52dc93bee4dd8b6dce4c7b8aa8237.json"}}, {"family": "Larsson", "given": "Emma", "initials": "E"}, {"family": "Block", "given": "Linda", "initials": "L", "orcid": "0000-0002-7736-0093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/829cb3512180455b874595d3f8f42730.json"}}], "type": "journal article", "published": "2023-09-05", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": null, "issue": null, "pages": null}, "abstract": "There are few studies on the differences in end-of-life decisions making in critically ill patients with and without coronavirus disease 2019 (COVID-19). This study aimed to investigate the independent factors that predicted the decision to withdraw or withhold life-sustaining treatments (LST) in critically ill patients and if these decisions were based on different variables for critically ill patients with COVID-19 compared to those for critically ill patients with other diagnoses in a Swedish intensive care unit.\r\n\r\nThis observational pilot study was performed at Sahlgrenska University Hospital, Gothenburg, Sweden. Patients \u226565 years were included from 1 March 2020 to 30 April 2021. The association between a decision to limit LST and a priori selected variables including sex, age, Simplified Acute Physiology Score 3 (SAPS 3), Clinical Frailty Scale \u22654, Charlson Comorbidity Index, Body Mass Index, living at home, invasive and non-invasive mechanical ventilation was assessed using a univariate and multivariable logistic regression model and presented as odds ratio with corresponding 95% confidence intervals.\r\n\r\nThere were 394 patients included in this study, 131 in the non-COVID-19 group and 263 in the COVID-19 group. For the non-COVID-19 cohort, the univariate analysis demonstrated that age and SAPS 3 were significantly associated with the decision to withdraw or withhold life-sustaining treatments, and this association remained in the multivariable analysis, with odds ratios of 1.10 (1.03-1.19) p = .009 and 1.06 (1.03-1.10) p < .001, respectively. For the COVID-19 cohort, the univariate analysis indicated that age, SAPS 3, and Charlson comorbidity index were significantly associated with the decision to withdraw or withhold life-sustaining treatments. However, in multivariable analysis, only the Charlson comorbidity index remained independently associated with the decision to withdraw or withhold life-sustaining treatments, with an odds ratio of 1.26 (1.07-1.49), p = .006.\r\n\r\nDecisions to withdraw or withhold life-sustaining treatments were based on other variables for the critically ill COVID-19 cohort compared to those for the critically ill non-COVID-19 cohort. Further studies are warranted to forge a common path for ethical end-of-life decision-making in critically ill patients.", "doi": "10.1111/aas.14326", "pmid": "37670491", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:55:09.867Z", "modified": "2023-10-06T10:45:20.324Z"}, {"entity": "publication", "iuid": "4ee3d80277934f77933848730ae1f433", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ee3d80277934f77933848730ae1f433.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ee3d80277934f77933848730ae1f433"}}, "title": "Correlates of breakthrough COVID-19 in vaccinated patients with systemic sclerosis: survival analysis from a multicentre international patient-reported survey.", "authors": [{"family": "Ahmed", "given": "Sakir", "initials": "S", "orcid": "0000-0003-4631-311X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd7df1f49c014c33b8ddaae05d8ac052.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Pauling", "given": "John D", "initials": "JD", "orcid": "0000-0002-2793-2364", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e37709273d404d17a88c7c850777b99f.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Ravichandran", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Jagtap", "given": "Kshitij", "initials": "K", "orcid": "0000-0003-2729-737X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822b9da98e5d4eb2975ff97fe484933f.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Saha", "given": "Sreoshy", "initials": "S", "orcid": "0000-0001-6745-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00238845dd4833ae51ffb75e2fe144.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Kardes", "given": "Sinan", "initials": "S", "orcid": "0000-0002-6311-8634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2900c3ca00da476a8914574384a3c9c2.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Wibowo", "given": "Suryo Anggoro Kusumo", "initials": "SAK"}, {"family": "COVAD Study Group", "given": "", "initials": ""}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}], "type": "journal article", "published": "2023-09-05", "journal": {"title": "Rheumatol Int", "issn": "1437-160X", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "This study aimed to assess the incidence, predictors, and outcomes of breakthrough infection (BI) following coronavirus disease (COVID-19) vaccination in patients with systemic sclerosis (SSc), a risk group associated with an immune-suppressed state and high cardiopulmonary disease burden. Cross-sectional data from fully vaccinated respondents with SSc, non-SSc autoimmune rheumatic diseases (AIRDs), and healthy controls (HCs) were extracted from the COVAD database, an international self-reported online survey. BI was defined according to the Centre for Disease Control definition. Infection-free survival was compared between the groups using Kaplan-Meier curves with log-rank tests. Cox proportional regression was used to assess the association between BI and age, sex, ethnicity, and immunosuppressive drugs at the time of vaccination. The severity of BI in terms of hospitalization and requirement for oxygen supplementation was compared between groups. Of 10,900 respondents, 6836 fulfilled the following inclusion criteria: 427 SSc, 2934 other AIRDs, and 3475 HCs. BI were reported in 6.3% of SSc, 6.9% of non-SSc AIRD, and 16.1% of HCs during a median follow-up of 100 (IQR: 60-137) days. SSc had a lower risk for BI than HC [hazard ratio (HR): 0.56 (95% CI 0.46-0.74)]. BIs were associated with age [HR: 0.98 (0.97-0.98)] but not ethnicity or immunosuppressive drugs at the time of vaccination. Patients with SSc were more likely to have asymptomatic COVID-19, but symptomatic patients reported more breathlessness. Hospitalization [SSc: 4 (14.8%), HCs: 37 (6.6%), non-SSc AIRDs: 32(15.8%)] and the need for oxygenation [SSc: 1 (25%); HC: 17 (45.9%); non-SSc AIRD: 13 (40.6%)] were similar between the groups. The incidence of BI in SSc was lower than that in HCs but comparable to that in non-SSc AIRDs. The severity of BI did not differ between the groups. Advancing age, but not ethnicity or immunosuppressive medication use, was associated with BIs.", "doi": "10.1007/s00296-023-05433-z", "pmid": "37668836", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00296-023-05433-z"}], "notes": [], "created": "2023-10-06T06:57:20.805Z", "modified": "2023-10-06T11:42:16.083Z"}, {"entity": "publication", "iuid": "7169dbc16bc04befabcac692ecef94df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7169dbc16bc04befabcac692ecef94df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7169dbc16bc04befabcac692ecef94df"}}, "title": "Post COVID-19 condition after SARS-CoV-2 infections during the omicron surge compared with the delta, alpha, and wild-type periods in Stockholm, Sweden.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P", "orcid": "0000-0003-3153-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd6af5accfc84ff9a81983a5ab6683aa.json"}}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2023-09-04", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899", "volume": null, "issue": null, "pages": null}, "abstract": "Little is known about post COVID-19 condition (PCC) after infections with different SARS-CoV-2 variants. We investigated the risk of PCC diagnosis after primary omicron infections compared with preceding variants in population-based cohorts in Stockholm, Sweden. Compared to omicron (n=215,279, 0.2% receiving a PCC diagnosis), the adjusted hazard ratio (95% confidence interval) was 3.26 (2.80 to 3.80) for delta (n=52,182, 0.5% PCC diagnosis), 5.33 (4.73 to 5.99) for alpha (n=97,978, 1.0% PCC diagnosis), and 6.31 (5.64 to 7.06) for wild-type (n=107,920, 1.3% PCC diagnosis). These findings were consistent across all subgroup analyses except among the ICU-treated.", "doi": "10.1093/infdis/jiad382", "pmid": "37665981", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Post-COVID": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "7259851"}], "notes": [], "created": "2023-10-06T06:52:43.737Z", "modified": "2023-10-06T09:54:10.819Z"}, {"entity": "publication", "iuid": "8452f5efb4e6418a9fef297f94232fce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8452f5efb4e6418a9fef297f94232fce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8452f5efb4e6418a9fef297f94232fce"}}, "title": "Oligomeric State of \u03b2-Coronavirus Non-Structural Protein 10 Stimulators Studied by Small Angle X-ray Scattering.", "authors": [{"family": "Knecht", "given": "Wolfgang", "initials": "W"}, {"family": "Fisher", "given": "S Zo\u00eb", "initials": "SZ"}, {"family": "Lou", "given": "Jiaqi", "initials": "J"}, {"family": "Sele", "given": "C\u00e9leste", "initials": "C"}, {"family": "Ma", "given": "Shumeng", "initials": "S"}, {"family": "Rasmussen", "given": "Anna Andersson", "initials": "AA"}, {"family": "Pinotsis", "given": "Nikos", "initials": "N"}, {"family": "Kozielski", "given": "Frank", "initials": "F", "orcid": "0000-0001-6096-9102", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8544f97e0f8841729c41626e742ec75f.json"}}], "type": "journal article", "published": "2023-09-04", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "issn-l": null, "volume": "24", "issue": "17", "pages": null}, "abstract": "The \u03b2-coronavirus family, encompassing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Severe Acute Respiratory Syndrome Coronavirus (SARS), and Middle East Respiratory Syndrome Coronavirus (MERS), has triggered pandemics within the last two decades. With the possibility of future pandemics, studying the coronavirus family members is necessary to improve knowledge and treatment. These viruses possess 16 non-structural proteins, many of which play crucial roles in viral replication and in other vital functions. One such vital protein is non-structural protein 10 (nsp10), acting as a pivotal stimulator of nsp14 and nsp16, thereby influencing RNA proofreading and viral RNA cap formation. Studying nsp10 of pathogenic coronaviruses is central to unraveling its multifunctional roles. Our study involves the biochemical and biophysical characterisation of full-length nsp10 from MERS, SARS and SARS-CoV-2. To elucidate their oligomeric state, we employed a combination of Multi-detection Size exclusion chromatography (Multi-detection SEC) with multi-angle static light scattering (MALS) and small angle X-ray scattering (SAXS) techniques. Our findings reveal that full-length nsp10s primarily exist as monomers in solution, while truncated versions tend to oligomerise. SAXS experiments reveal a globular shape for nsp10, a trait conserved in all three coronaviruses, although MERS nsp10, diverges most from SARS and SARS-CoV-2 nsp10s. In summary, unbound nsp10 proteins from SARS, MERS, and SARS-CoV-2 exhibit a globular and predominantly monomeric state in solution.", "doi": "10.3390/ijms241713649", "pmid": "37686452", "labels": {"Type: Journal article": null, "Category: Proteins": null, "Category: Imaging": null}, "xrefs": [{"db": "pii", "key": "ijms241713649"}], "notes": [], "created": "2023-10-06T06:57:03.206Z", "modified": "2023-10-06T11:34:06.712Z"}, {"entity": "publication", "iuid": "862c7810ef7a48d7b6334953b87bc98c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/862c7810ef7a48d7b6334953b87bc98c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/862c7810ef7a48d7b6334953b87bc98c"}}, "title": "Reducing intrusive memories after trauma via an imagery-competing task intervention in COVID-19 intensive care staff: a randomised controlled trial.", "authors": [{"family": "Iyadurai", "given": "Lalitha", "initials": "L"}, {"family": "Highfield", "given": "Julie", "initials": "J"}, {"family": "Kanstrup", "given": "Marie", "initials": "M", "orcid": "0000-0003-2060-5288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86830095163d4e14b62d78e8ed149b2e.json"}}, {"family": "Markham", "given": "Alfred", "initials": "A"}, {"family": "Ramineni", "given": "Varsha", "initials": "V", "orcid": "0000-0002-0330-3184", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9d359662cf044ac8308614e0f62f908.json"}}, {"family": "Guo", "given": "Boliang", "initials": "B"}, {"family": "Jaki", "given": "Thomas", "initials": "T"}, {"family": "Kingslake", "given": "Jonathan", "initials": "J", "orcid": "0000-0003-1741-1802", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d55190abd6f5468f8cb4f1890b0744fc.json"}}, {"family": "Goodwin", "given": "Guy M", "initials": "GM"}, {"family": "Summers", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-7269-2873", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd46e0acccc1403eae9148a5273f1a71.json"}}, {"family": "Bonsall", "given": "Michael B", "initials": "MB", "orcid": "0000-0003-0250-0423", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf8ee242158a4422ab7f8c00fb827150.json"}}, {"family": "Holmes", "given": "Emily A", "initials": "EA", "orcid": "0000-0001-7319-3112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be06518242494a02bd7cb6cf60a67541.json"}}], "type": "randomized controlled trial", "published": "2023-09-01", "journal": {"title": "Transl Psychiatry", "issn": "2158-3188", "issn-l": null, "volume": "13", "issue": "1", "pages": "290"}, "abstract": "Intrusive memories (IMs) after traumatic events can be distressing and disrupt mental health and functioning. We evaluated the impact of a brief remotely-delivered digital imagery-competing task intervention on the number of IMs for intensive care unit (ICU) staff who faced repeated trauma exposure during the COVID-19 pandemic using a two-arm, parallel-group, single-blind randomised controlled trial, with the comparator arm receiving delayed access to active treatment (crossover). Eligible participants worked clinically in a UK NHS ICU during the pandemic and had at least 3 IMs of work-related traumatic events in the week before recruitment. Participants were randomly assigned (1:1) to immediate (weeks 1-4) or delayed (weeks 5-8) intervention access. Sequential Bayesian analyses to optimise the intervention and increase trial efficiency are reported elsewhere [1]. The primary endpoint for the pre-specified frequentist analysis of the final study population compared the number of IMs experienced in week 4 between the immediate and delayed access arms. Secondary outcomes included clinical symptoms, work functioning and wellbeing. Safety was assessed throughout the trial by scheduled questions and free report. All analyses were undertaken on an intention-to-treat basis (86 randomised participants). There were significantly fewer intrusive memories during week 4 in the immediate (median = 1, IQR = 0-3, n = 43), compared to the comparator delayed arm (median = 10, IQR = 6-17, n = 43), IRR 0.31, 95% CI: 0.20-0.48, p < 0.001. After crossover, the delayed arm also showed a significant reduction in IMs at week 8 compared to week 4. There were convergent findings for symptoms of PTSD, insomnia and anxiety, work engagement and burnout, general functioning and quality of life. The intervention was found safe and acceptable to participants. All adverse events were unrelated to the study. Our study provides the first evidence of a benefit on reducing IMs, improving other clinical symptoms, work functioning and wellbeing, as well as safety of a brief remotely-delivered digital imagery-competing task intervention. An efficacy trial with an active control and longer follow-up is warranted. The trial is registered at ClinicalTrials.gov (NCT04992390).", "doi": "10.1038/s41398-023-02578-0", "pmid": "37658043", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10474101"}, {"db": "pii", "key": "10.1038/s41398-023-02578-0"}, {"db": "ClinicalTrials.gov", "key": "NCT04992390"}], "notes": [], "created": "2023-10-06T06:57:39.451Z", "modified": "2023-10-06T11:46:28.613Z"}, {"entity": "publication", "iuid": "8d698dc394ec4e62b585236343b3bc0f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d698dc394ec4e62b585236343b3bc0f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d698dc394ec4e62b585236343b3bc0f"}}, "title": "Radiological appearance and lung function six months after invasive ventilation in ICU for COVID-19 pneumonia: An observational follow-up study.", "authors": [{"family": "Konsberg", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-1542-5402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24e0c2f7ceaa45958a0a059f4e4f322d.json"}}, {"family": "Szaro", "given": "Pawel", "initials": "P"}, {"family": "Aneman", "given": "Anders", "initials": "A"}, {"family": "Kjellberg", "given": "Sanna", "initials": "S"}, {"family": "Solidakis", "given": "Nektarios", "initials": "N"}, {"family": "Svedlund", "given": "Sara", "initials": "S"}, {"family": "Nellg\u00e5rd", "given": "Bengt", "initials": "B"}, {"family": "Dalla", "given": "Keti", "initials": "K", "orcid": "0000-0001-7367-2500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f1c43bc04bf49a7adc3559aa5deb916.json"}}], "type": "observational study", "published": "2023-09-01", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "9", "pages": "e0289603"}, "abstract": "Respiratory functional sequelae in COVID-19 patients admitted to the intensive care unit for invasive ventilation are sparsely reported. The aim of this study was to investigate the radiological lung appearance, lung function and their association at 6 months after hospital discharge. It was hypothesized that the degree of pathological morphology on CT scans would correlate with lung function at the time of follow-up.\r\n\r\nIn this single-centre prospective observational study, 86 from 154 patients admitted to ICU due to COVID-19 between March 2020 and May 2021 were followed up at 6 months post discharge with computed tomography (CT) of the chest and pulmonary function tests (PFTs). The PFT results were expressed as z-scores calculated as the difference between the measured and predicted values divided by the standard deviation obtained from a reference population. Correlations were evaluated by Spearman's rho including the 95% confidence interval. Pathological changes on CT were found in 78/85 participants with fibrous parenchymal bands being the most prevalent finding (91%) followed by traction bronchiectasis (64%) and ground glass opacities (41%). Sixty-five participants performed PFTs, and a restrictive pattern was the most prevalent abnormality (34%). Diffusing capacity of the lung for carbon monoxide (DLCO) was reduced in 66% of participants. The CT severity score weakly correlated with forced vital capacity (FVC) z-score (0.295, p = 0.006), DLCO z-score (-0.231, p = 0.032) and alveolar volume (VA) z-score (0.253, p = 0.019).\r\n\r\nMost patients showed persistent radiological abnormalities on CT and reduced lung volumes, impaired diffusion capacity and patterns of restrictive lung function at 6 months post discharge from the ICU. The correlations between abnormalities on CT and lung function tests were weak. Further, studies with a long-term follow-up of lung function in this group of patients are needed.", "doi": "10.1371/journal.pone.0289603", "pmid": "37656699", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Imaging": null}, "xrefs": [{"db": "pmc", "key": "PMC10473523"}, {"db": "pii", "key": "PONE-D-22-31787"}], "notes": [], "created": "2023-10-06T06:57:08.003Z", "modified": "2023-10-06T11:37:14.743Z"}, {"entity": "publication", "iuid": "0fffeafdba3d43eaae8050e352b1b921", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0fffeafdba3d43eaae8050e352b1b921.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0fffeafdba3d43eaae8050e352b1b921"}}, "title": "Pentameric C-reactive protein is a better prognostic biomarker and remains elevated for longer than monomeric CRP in hospitalized patients with COVID-19.", "authors": [{"family": "Hopkins", "given": "Francis R", "initials": "FR"}, {"family": "Nordgren", "given": "Johan", "initials": "J"}, {"family": "Fernandez-Botran", "given": "Rafael", "initials": "R"}, {"family": "Enocsson", "given": "Helena", "initials": "H"}, {"family": "Govender", "given": "Melissa", "initials": "M"}, {"family": "Svanberg", "given": "Cecilia", "initials": "C"}, {"family": "Svensson", "given": "Lennart", "initials": "L"}, {"family": "Hagbom", "given": "Marie", "initials": "M"}, {"family": "Nilsdotter-Augustinsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Nystr\u00f6m", "given": "Sofia", "initials": "S"}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C"}, {"family": "Sj\u00f6wall", "given": "Johanna", "initials": "J"}, {"family": "Larsson", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2023-09-01", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "1259005"}, "abstract": "The differing roles of the pentameric (p) and monomeric (m) C-reactive protein (CRP) isoforms in viral diseases are not fully understood, which was apparent during the COVID-19 pandemic regarding the clinical course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Herein, we investigated the predictive value of the pCRP and mCRP isoforms for COVID-19 severity in hospitalized patients and evaluated how the levels of the protein isoforms changed over time during and after acute illness. This study utilized samples from a well-characterized cohort of Swedish patients with SARS-CoV-2 infection, the majority of whom had known risk factors for severe COVID-19 and required hospitalization. The levels of pCRP were significantly raised in patients with severe COVID-19 and in contrast to mCRP the levels were significantly associated with disease severity. Additionally, the pCRP levels remained elevated for at least six weeks post inclusion, which was longer compared to the two weeks for mCRP. Our data indicates a low level of inflammation lasting for at least six weeks following COVID-19, which might indicate that the disease has an adverse effect on the immune system even after the viral infection is resolved. It is also clear that the current standard method of testing pCRP levels upon hospitalization is a useful marker for predicting disease severity and mCRP testing would not add any clinical relevance for patients with COVID-19.", "doi": "10.3389/fimmu.2023.1259005", "pmid": "37724104", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Proteins": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10505432"}], "notes": [], "created": "2023-10-06T06:52:15.856Z", "modified": "2023-10-06T08:29:02.801Z"}, {"entity": "publication", "iuid": "d953102b4ac049d68c80a689db691673", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d953102b4ac049d68c80a689db691673.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d953102b4ac049d68c80a689db691673"}}, "title": "Occupational risks associated with severe COVID-19 disease and SARS-CoV-2 infection - a Swedish national case-control study conducted from October 2020 to December 2021.", "authors": [{"family": "Tor\u00e9n", "given": "Kjell", "initials": "K"}, {"family": "Albin", "given": "Maria", "initials": "M"}, {"family": "Bergstr\u00f6m", "given": "Tomas", "initials": "T"}, {"family": "Murgia", "given": "Nicola", "initials": "N"}, {"family": "Alderling", "given": "Magnus", "initials": "M"}, {"family": "Schi\u00f6ler", "given": "Linus", "initials": "L"}, {"family": "\u00c5berg", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2023-09-01", "journal": {"title": "Scand J Work Environ Health", "issn": "1795-990X", "issn-l": null, "volume": "49", "issue": "6", "pages": "386-394"}, "abstract": "This study aimed to investigate whether workplace factors and occupations are associated with SARS-CoV-2 infection or severe COVID-19 in the later waves of the pandemic.\r\n\r\nWe studied 552 562 cases with a positive test for SARS-CoV-2 in the Swedish registry of communicable diseases, and 5985 cases with severe COVID-19 based on hospital admissions from October 2020 to December 2021. Four population controls were assigned the index dates of their corresponding cases. We linked job histories to job-exposure matrices to assess the odds for different transmission dimensions and different occupations. We used adjusted conditional logistic analyses to estimate odds ratios (OR) for severe COVID-19 and SARS-CoV-2 with 95% confidence intervals (CI).\r\n\r\nThe highest OR for severe COVID-19 were for: regular contact with infected patients, (OR 1.37, 95% CI 1.23-1.54), close physical proximity (OR 1.47, 95% CI 1.34-1.61), and high exposure to diseases or infections (OR 1.72, 95% CI 1.52-1.96). Mostly working outside had lower OR (OR 0.77, 95% CI 0.57-1.06). The odds for SARS-CoV-2 when mostly working outside were similar (OR 0.83, 95% CI 0.80-0.86). The occupation with the highest OR for severe COVID-19 (compared with low-exposure occupations) was certified specialist physician (OR 2.05, 95% CI 1.31-3.21) among women and bus and tram drivers (OR 2.04, 95% CI 1.49-2.79) among men.\r\n\r\nContact with infected patients, close proximity and crowded workplaces increase the risks for severe COVID-19 and SARS-CoV-2 infection. Outdoor work is associated with decreased odds for SARS-CoV-2 infection and severe COVID-19.", "doi": "10.5271/sjweh.4103", "pmid": "37417898", "labels": {"Type: Journal article": null, "Funder: Forte": null, "Category: Other": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "4103"}], "notes": [], "created": "2023-10-04T12:07:32.911Z", "modified": "2023-10-04T12:16:58.601Z"}, {"entity": "publication", "iuid": "6cc1aecaf6a34214b4f33d84c367e7c2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6cc1aecaf6a34214b4f33d84c367e7c2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6cc1aecaf6a34214b4f33d84c367e7c2"}}, "title": "Trends in invasive bacterial diseases during the first 2 years of the COVID-19 pandemic: analyses of prospective surveillance data from 30 countries and territories in the IRIS Consortium.", "authors": [{"family": "Shaw", "given": "David", "initials": "D"}, {"family": "Abad", "given": "Raquel", "initials": "R"}, {"family": "Amin-Chowdhury", "given": "Zahin", "initials": "Z"}, {"family": "Bautista", "given": "Adriana", "initials": "A"}, {"family": "Bennett", "given": "Desiree", "initials": "D"}, {"family": "Broughton", "given": "Karen", "initials": "K"}, {"family": "Cao", "given": "Bin", "initials": "B"}, {"family": "Casanova", "given": "Carlo", "initials": "C"}, {"family": "Choi", "given": "Eun Hwa", "initials": "EH"}, {"family": "Chu", "given": "Yiu-Wai", "initials": "Y"}, {"family": "Claus", "given": "Heike", "initials": "H"}, {"family": "Coelho", "given": "Juliana", "initials": "J"}, {"family": "Corcoran", "given": "Mary", "initials": "M"}, {"family": "Cottrell", "given": "Simon", "initials": "S"}, {"family": "Cunney", "given": "Robert", "initials": "R"}, {"family": "Cuypers", "given": "Lize", "initials": "L"}, {"family": "Dalby", "given": "Tine", "initials": "T"}, {"family": "Davies", "given": "Heather", "initials": "H"}, {"family": "de Gouveia", "given": "Linda", "initials": "L"}, {"family": "Deghmane", "given": "Ala-Eddine", "initials": "A"}, {"family": "Demczuk", "given": "Walter", "initials": "W"}, {"family": "Desmet", "given": "Stefanie", "initials": "S"}, {"family": "Domenech", "given": "Mirian", "initials": "M"}, {"family": "Drew", "given": "Richard", "initials": "R"}, {"family": "du Plessis", "given": "Mignon", "initials": "M"}, {"family": "Duarte", "given": "Carolina", "initials": "C"}, {"family": "Erlendsd\u00f3ttir", "given": "Helga", "initials": "H"}, {"family": "Fry", "given": "Norman K", "initials": "NK"}, {"family": "Fuursted", "given": "Kurt", "initials": "K"}, {"family": "Hale", "given": "Thomas", "initials": "T"}, {"family": "Henares", "given": "Desiree", "initials": "D"}, {"family": "Henriques-Normark", "given": "Birgitta", "initials": "B"}, {"family": "Hilty", "given": "Markus", "initials": "M"}, {"family": "Hoffmann", "given": "Steen", "initials": "S"}, {"family": "Humphreys", "given": "Hilary", "initials": "H"}, {"family": "Ip", "given": "Margaret", "initials": "M"}, {"family": "Jacobsson", "given": "Susanne", "initials": "S"}, {"family": "Johnson", "given": "Christopher", "initials": "C"}, {"family": "Johnston", "given": "Jillian", "initials": "J"}, {"family": "Jolley", "given": "Keith A", "initials": "KA"}, {"family": "Kawabata", "given": "An\u00edbal", "initials": "A"}, {"family": "Kozakova", "given": "Jana", "initials": "J"}, {"family": "Kristinsson", "given": "Karl G", "initials": "KG"}, {"family": "Krizova", "given": "Pavla", "initials": "P"}, {"family": "Kuch", "given": "Alicja", "initials": "A"}, {"family": "Ladhani", "given": "Shamez", "initials": "S"}, {"family": "L\u00e2m", "given": "Thi\u00ean-Tr\u00ed", "initials": "T"}, {"family": "Le\u00f3n", "given": "Mar\u00eda Eugenia", "initials": "ME"}, {"family": "Lindholm", "given": "Laura", "initials": "L"}, {"family": "Litt", "given": "David", "initials": "D"}, {"family": "Maiden", "given": "Martin C J", "initials": "MCJ"}, {"family": "Martin", "given": "Irene", "initials": "I"}, {"family": "Martiny", "given": "Delphine", "initials": "D"}, {"family": "Mattheus", "given": "Wesley", "initials": "W"}, {"family": "McCarthy", "given": "Noel D", "initials": "ND"}, {"family": "Meehan", "given": "Mary", "initials": "M"}, {"family": "Meiring", "given": "Susan", "initials": "S"}, {"family": "M\u00f6lling", "given": "Paula", "initials": "P"}, {"family": "Morfeldt", "given": "Eva", "initials": "E"}, {"family": "Morgan", "given": "Julie", "initials": "J"}, {"family": "Mulhall", "given": "Robert", "initials": "R"}, {"family": "Mu\u00f1oz-Almagro", "given": "Carmen", "initials": "C"}, {"family": "Murdoch", "given": "David", "initials": "D"}, {"family": "Murphy", "given": "Joy", "initials": "J"}, {"family": "Musilek", "given": "Martin", "initials": "M"}, {"family": "Mzabi", "given": "Alexandre", "initials": "A"}, {"family": "Novakova", "given": "Ludmila", "initials": "L"}, {"family": "Oftadeh", "given": "Shahin", "initials": "S"}, {"family": "Perez-Arg\u00fcello", "given": "Amaresh", "initials": "A"}, {"family": "P\u00e9rez-V\u00e1zquez", "given": "Maria", "initials": "M"}, {"family": "Perrin", "given": "Monique", "initials": "M"}, {"family": "Perry", "given": "Malorie", "initials": "M"}, {"family": "Prevost", "given": "Benoit", "initials": "B"}, {"family": "Roberts", "given": "Maria", "initials": "M"}, {"family": "Rokney", "given": "Assaf", "initials": "A"}, {"family": "Ron", "given": "Merav", "initials": "M"}, {"family": "Sanabria", "given": "Olga Marina", "initials": "OM"}, {"family": "Scott", "given": "Kevin J", "initials": "KJ"}, {"family": "Sheppard", "given": "Carmen", "initials": "C"}, {"family": "Siira", "given": "Lotta", "initials": "L"}, {"family": "Sintchenko", "given": "Vitali", "initials": "V"}, {"family": "Skoczy\u0144ska", "given": "Anna", "initials": "A"}, {"family": "Sloan", "given": "Monica", "initials": "M"}, {"family": "Slotved", "given": "Hans-Christian", "initials": "H"}, {"family": "Smith", "given": "Andrew J", "initials": "AJ"}, {"family": "Steens", "given": "Anneke", "initials": "A"}, {"family": "Taha", "given": "Muhamed-Kheir", "initials": "M"}, {"family": "Toropainen", "given": "Maija", "initials": "M"}, {"family": "Tzanakaki", "given": "Georgina", "initials": "G"}, {"family": "Vainio", "given": "Anni", "initials": "A"}, {"family": "van der Linden", "given": "Mark P G", "initials": "MPG"}, {"family": "van Sorge", "given": "Nina M", "initials": "NM"}, {"family": "Varon", "given": "Emmanuelle", "initials": "E"}, {"family": "Vohrnova", "given": "Sandra", "initials": "S"}, {"family": "von Gottberg", "given": "Anne", "initials": "A"}, {"family": "Yuste", "given": "Jose", "initials": "J"}, {"family": "Zanella", "given": "Rosemeire", "initials": "R"}, {"family": "Zhou", "given": "Fei", "initials": "F"}, {"family": "Brueggemann", "given": "Angela B", "initials": "AB"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "The Lancet Digital Health", "issn": "2589-7500", "issn-l": null, "volume": "5", "issue": "9", "pages": "e582-e593"}, "abstract": "The Invasive Respiratory Infection Surveillance (IRIS) Consortium was established to assess the impact of the COVID-19 pandemic on invasive diseases caused by Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, and Streptococcus agalactiae. We aimed to analyse the incidence and distribution of these diseases during the first 2 years of the COVID-19 pandemic compared to the 2 years preceding the pandemic.\r\n\r\nFor this prospective analysis, laboratories in 30 countries and territories representing five continents submitted surveillance data from Jan 1, 2018, to Jan 2, 2022, to private projects within databases in PubMLST. The impact of COVID-19 containment measures on the overall number of cases was analysed, and changes in disease distributions by patient age and serotype or group were examined. Interrupted time-series analyses were done to quantify the impact of pandemic response measures and their relaxation on disease rates, and autoregressive integrated moving average models were used to estimate effect sizes and forecast counterfactual trends by hemisphere.\r\n\r\nOverall, 116 841 cases were analysed: 76 481 in 2018-19, before the pandemic, and 40 360 in 2020-21, during the pandemic. During the pandemic there was a significant reduction in the risk of disease caused by S pneumoniae (risk ratio 0\u00b747; 95% CI 0\u00b740-0\u00b755), H influenzae (0\u00b751; 0\u00b740-0\u00b766) and N meningitidis (0\u00b726; 0\u00b721-0\u00b731), while no significant changes were observed for S agalactiae (1\u00b702; 0\u00b775-1\u00b740), which is not transmitted via the respiratory route. No major changes in the distribution of cases were observed when stratified by patient age or serotype or group. An estimated 36 289 (95% prediction interval 17 145-55 434) cases of invasive bacterial disease were averted during the first 2 years of the pandemic among IRIS-participating countries and territories.\r\n\r\nCOVID-19 containment measures were associated with a sustained decrease in the incidence of invasive disease caused by S pneumoniae, H influenzae, and N meningitidis during the first 2 years of the pandemic, but cases began to increase in some countries towards the end of 2021 as pandemic restrictions were lifted. These IRIS data provide a better understanding of microbial transmission, will inform vaccine development and implementation, and can contribute to health-care service planning and provision of policies.\r\n\r\nWellcome Trust, NIHR Oxford Biomedical Research Centre, Spanish Ministry of Science and Innovation, Korea Disease Control and Prevention Agency, Torsten S\u00f6derberg Foundation, Stockholm County Council, Swedish Research Council, German Federal Ministry of Health, Robert Koch Institute, Pfizer, Merck, and the Greek National Public Health Organization.", "doi": "10.1016/S2589-7500(23)00108-5", "pmid": "37516557", "labels": {"Funder: VR": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2589-7500(23)00108-5"}], "notes": [], "created": "2023-10-04T12:10:31.535Z", "modified": "2023-10-04T13:15:07.482Z"}, {"entity": "publication", "iuid": "3b387324ed684abbae797117ddd0f81d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b387324ed684abbae797117ddd0f81d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b387324ed684abbae797117ddd0f81d"}}, "title": "The impact of the COVID-19 pandemic on children's learning and wellbeing: Evidence from India.", "authors": [{"family": "Guariso", "given": "Andrea", "initials": "A"}, {"family": "Bj\u00f6rkman Nyqvist", "given": "Martina", "initials": "M"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "J Dev Econ", "issn": "0304-3878", "issn-l": null, "volume": "164", "issue": null, "pages": "103133"}, "abstract": "We study the impact of the COVID-19 pandemic and associated school closure on primary school children's learning and mental wellbeing in Assam, India. Using a comprehensive dataset that tracked and repeatedly surveyed approximately 5000 children across 200 schools between 2018 and 2022, we find that children lost the equivalent of nine months of learning in mathematics and eleven months in language, during the pandemic. Children lacking resources and parental support experienced the largest losses. Regular practice, teacher interaction, and technology were associated with less learning loss. Over the same period, children's psychological wellbeing improved. Our research provides valuable insights for designing post-emergency programs.", "doi": "10.1016/j.jdeveco.2023.103133", "pmid": "37342545", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10264163"}, {"db": "pii", "key": "S0304-3878(23)00088-3"}], "notes": [], "created": "2023-10-04T09:32:19.037Z", "modified": "2023-10-04T11:01:58.570Z"}, {"entity": "publication", "iuid": "1c7f7c858ead4b93b04d424ae469e1fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1c7f7c858ead4b93b04d424ae469e1fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1c7f7c858ead4b93b04d424ae469e1fc"}}, "title": "Seasonal influence on respiratory tract infection severity including COVID-19 quantified through Markov Chain modeling.", "authors": [{"family": "van Wijk", "given": "Rob C", "initials": "RC", "orcid": "0000-0001-7247-1360", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aac8bd1a2d674d6c891c1a0becf997d8.json"}}, {"family": "Mockeliunas", "given": "Laurynas", "initials": "L", "orcid": "0000-0002-7008-4946", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f6959d9dd1f42a1abdd09bdf8d739f3.json"}}, {"family": "Upton", "given": "Caryn M", "initials": "CM"}, {"family": "Peter", "given": "Jonathan", "initials": "J"}, {"family": "Diacon", "given": "Andreas H", "initials": "AH"}, {"family": "Simonsson", "given": "Ulrika S H", "initials": "USH", "orcid": "0000-0002-3424-9686", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf510f552f2846b5bbb7740872a7c24a.json"}}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "CPT Pharmacometrics Syst. Pharmacol.", "issn": "2163-8306", "issn-l": null, "volume": "12", "issue": "9", "pages": "1250-1261"}, "abstract": "Respiratory tract infections (RTIs) are a burden to global health, but their characterization is complicated by the influence of seasonality on incidence and severity. The Re-BCG-CoV-19 trial (NCT04379336) assessed BCG (re)vaccination for protection from coronavirus disease 2019 (COVID-19) and recorded 958 RTIs in 574 individuals followed over 1 year. We characterized the probability of RTI occurrence and severity using a Markov model with health scores (HSs) for four states of symptom severity. Covariate analysis on the transition probability between HSs explored the influence of demographics, medical history, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), or influenza vaccinations, which became available during the trial, SARS-CoV-2 serology, and epidemiology-informed seasonal influence of infection pressure represented as regional COVID-19 pandemic waves, as well as BCG (re)vaccination. The infection pressure reflecting the pandemic waves increased the risk of RTI symptom development, whereas the presence of SARS-CoV-2 antibodies protected against RTI symptom development and increased the probability of symptom relief. Higher probability of symptom relief was also found in participants with African ethnicity and with male biological gender. SARS-CoV-2 or influenza vaccination reduced the probability of transitioning from mild to healthy symptoms. Model diagnostics over calendar-time indicated that COVID-19 cases were under-reported during the first wave by an estimated 2.76-fold. This trial was performed during the initial phase of the COVID-19 pandemic in South Africa and the results reflect that situation. Using this unique clinical dataset of prospectively studied RTIs over the course of 1 year, our Markov Chain model was able to capture risk factors for RTI development and severity, including epidemiology-informed infection pressure.", "doi": "10.1002/psp4.13006", "pmid": "37401774", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10508522"}, {"db": "ClinicalTrials.gov", "key": "NCT04379336"}], "notes": [], "created": "2023-10-04T12:07:40.665Z", "modified": "2023-10-04T12:22:15.271Z"}, {"entity": "publication", "iuid": "ed5ee9e208d34b9283c8973da3e782a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed5ee9e208d34b9283c8973da3e782a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed5ee9e208d34b9283c8973da3e782a1"}}, "title": "Operational challenges and mitigation measures during the COVID-19 pandemic-Lessons from DELIVER.", "authors": [{"family": "Bhatt", "given": "Ankeet S", "initials": "AS"}, {"family": "Lindholm", "given": "Daniel", "initials": "D"}, {"family": "Nilsson", "given": "Ann", "initials": "A"}, {"family": "Zaozerska", "given": "Natalia", "initials": "N"}, {"family": "Claggett", "given": "Brian L", "initials": "BL"}, {"family": "Vaduganathan", "given": "Muthiah", "initials": "M"}, {"family": "Kosiborod", "given": "Mikhail N", "initials": "MN"}, {"family": "Lam", "given": "Carolyn S P", "initials": "CSP"}, {"family": "Hernandez", "given": "Adrian F", "initials": "AF"}, {"family": "Martinez", "given": "Felipe A", "initials": "FA"}, {"family": "Inzucchi", "given": "Silvio E", "initials": "SE"}, {"family": "Shah", "given": "Sanjiv J", "initials": "SJ"}, {"family": "de Boer", "given": "Rudolf A", "initials": "RA"}, {"family": "Desai", "given": "Akshay", "initials": "A"}, {"family": "Jhund", "given": "Pardeep S", "initials": "PS"}, {"family": "Langkilde", "given": "Anna Maria", "initials": "AM"}, {"family": "Petersson", "given": "Magnus", "initials": "M"}, {"family": "McMurray", "given": "John J V", "initials": "JJV"}, {"family": "Solomon", "given": "Scott D", "initials": "SD"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Am Heart J", "issn": "1097-6744", "issn-l": null, "volume": "263", "issue": null, "pages": "133-140"}, "abstract": "Catastrophic disruptions in care delivery threaten the operational efficiency and potentially the validity of clinical research efforts, in particular randomized clinical trials. Most recently, the COVID-19 pandemic affected essentially all aspects of care delivery and clinical research conduct. While consensus statements and clinical guidance documents have detailed potential mitigation measures, few real-world experiences detailing clinical trial adaptations to the COVID-19 pandemic exist, particularly among, large, global registrational cardiovascular trials.\r\n\r\nWe outline the operational impact of COVID-19 and resultant mitigation measures in the Dapagliflozin Evaluation to Improve the LIVEs of Patients with Preserved Ejection Fraction Heart Failure (DELIVER) trial, one of the largest and most globally diverse experiences with COVID-19 of any cardiovascular clinical trial to date. Specifically, we address the needed coordination between academic investigators, trial leadership, clinical sites, and the supporting sponsor to ensure the safety of participants and trial staff, to maintain the fidelity of trial operations, and to prospectively adapt statistical analyses plans to evaluate the impact of COVID-19 and the pandemic at large on trial participants. These discussions included key operational issues such as ensuring delivery of study medications, adaptations to study visits, enhanced COVID-19 related endpoint adjudication, and protocol and analytical plan revisions.\r\n\r\nOur findings may have important implications for establishing consensus on prospective contingency planning in future clinical trials.\r\n\r\ngov: NCT03619213.\r\n\r\nGOV: NCT03619213.", "doi": "10.1016/j.ahj.2023.05.013", "pmid": "37220822", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10200275"}, {"db": "pii", "key": "S0002-8703(23)00132-1"}, {"db": "ClinicalTrials.gov", "key": "NCT03619213"}], "notes": [], "created": "2023-10-04T05:10:17.305Z", "modified": "2023-10-04T06:33:48.984Z"}, {"entity": "publication", "iuid": "cde59eddc81548a1abc15d6ffe2a194a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cde59eddc81548a1abc15d6ffe2a194a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cde59eddc81548a1abc15d6ffe2a194a"}}, "title": "Multiple manifestations of uncontrolled asthma increase the risk of severe COVID-19.", "authors": [{"family": "Selberg", "given": "Stina", "initials": "S"}, {"family": "Karlsson Sundbaum", "given": "Johanna", "initials": "J"}, {"family": "Konradsen", "given": "Jon R", "initials": "JR"}, {"family": "Backman", "given": "Helena", "initials": "H"}, {"family": "Hedman", "given": "Linnea", "initials": "L"}, {"family": "Lindberg", "given": "Anne", "initials": "A"}, {"family": "Stridsman", "given": "Caroline", "initials": "C"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Respir Med", "issn": "1532-3064", "issn-l": "0954-6111", "volume": "216", "issue": null, "pages": "107308"}, "abstract": "Asthma control is of importance when assessing the risk of severe outcomes of COVID-19. The aim of this study was to explore associations of clinical characteristics and the effect of multiple manifestations of uncontrolled asthma with severe COVID-19.\r\n\r\nIn 2014-2020, adult patients with uncontrolled asthma, defined as Asthma Control Test (ACT) \u226419 were identified in the Swedish National Airway Register (SNAR) (n = 24533). The SNAR database, including clinical data, was linked with national registers to identify patients with severe COVID-19 (n = 221). The effect of multiple manifestations of uncontrolled asthma was based on: 1) ACT \u226415, 2) frequent exacerbations and 3) previous asthma inpatient/secondary care and evaluated stepwise. Poisson regression analyses were conducted with severe COVID-19 as the dependent variable.\r\n\r\nIn this cohort with uncontrolled asthma, obesity was the strongest independent risk factor for severe COVID-19 in both sexes, but even greater in men. Multiple manifestations of uncontrolled asthma were more common among those with severe COVID-19 vs. without: one, 45.7 vs. 42.3%, two, 18.1 vs. 9.1% and three, 5.0 vs. 2.1%. The risk ratio (RR) of severe COVID-19 increased with an increasing number of manifestations of uncontrolled asthma: one, RR 1.49 (95% CI 1.09-2.02), two, RR 2.42 (95% CI 1.64-3.57) and three, RR 2.96 (95% CI 1.57-5.60), when adjusted for sex, age, and BMI.\r\n\r\nIt is important to consider the effect of multiple manifestations of uncontrolled asthma and obesity when assessing patients with COVID-19, as this increases the risk of severe outcomes substantially.", "doi": "10.1016/j.rmed.2023.107308", "pmid": "37271301", "labels": {"Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10238115"}, {"db": "pii", "key": "S0954-6111(23)00196-8"}], "notes": [], "created": "2023-10-04T09:30:31.135Z", "modified": "2023-10-04T09:57:30.750Z"}, {"entity": "publication", "iuid": "a39c2ff1e6d94a1f951e4c3f635d65f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a39c2ff1e6d94a1f951e4c3f635d65f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a39c2ff1e6d94a1f951e4c3f635d65f0"}}, "title": "Long-term safety of COVID vaccination in individuals with idiopathic inflammatory myopathies: results from the COVAD study.", "authors": [{"family": "Doskaliuk", "given": "Bohdana", "initials": "B", "orcid": "0000-0003-1650-8928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5c55895beec4f5fa9fe0545f38b72d1.json"}}, {"family": "Ravichandran", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Saha", "given": "Sreoshy", "initials": "S", "orcid": "0000-0001-6745-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00238845dd4833ae51ffb75e2fe144.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Jagtap", "given": "Kshitij", "initials": "K", "orcid": "0000-0003-2729-737X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822b9da98e5d4eb2975ff97fe484933f.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Chen", "given": "Yi Ming", "initials": "YM", "orcid": "0000-0001-7593-3065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/795f1bf1d4824521a3301f7c50f62bc4.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Patel", "given": "Aarat", "initials": "A"}, {"family": "Pauling", "given": "John D", "initials": "JD", "orcid": "0000-0002-2793-2364", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e37709273d404d17a88c7c850777b99f.json"}}, {"family": "Wincup", "given": "Chris", "initials": "C", "orcid": "0000-0002-8742-8311", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a674f02e7f7f45f58167eb24f81502f3.json"}}, {"family": "Barman", "given": "Bhupen", "initials": "B", "orcid": "0000-0002-5433-1310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7747785ec5fa4743bc70bd20fbca10fd.json"}}, {"family": "Tehozol", "given": "Erick Adrian Zamora", "initials": "EAZ", "orcid": "0000-0002-7888-3961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a55c695ac4f4003993a2f511cca7739.json"}}, {"family": "Serrano", "given": "Jorge Rojas", "initials": "JR", "orcid": "0000-0001-6980-7898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/225fd8b396ac40f4a77f1ec229c086b6.json"}}, {"family": "La Torre", "given": "Ignacio Garc\u00eda-De", "initials": "IG", "orcid": "0000-0002-9261-678X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/086b85d66fb84b50bd51bbe5a979dfe3.json"}}, {"family": "Colunga-Pedraza", "given": "Iris J", "initials": "IJ", "orcid": "0000-0002-2786-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50e46ef2c7f44b39a1d28fea6a8e621d.json"}}, {"family": "Merayo-Chalico", "given": "Javier", "initials": "J", "orcid": "0000-0002-5870-0523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d74c0ab33cbe4df586e1a1add37d0e65.json"}}, {"family": "Chibuzo", "given": "Okwara Celestine", "initials": "OC", "orcid": "0000-0002-7727-5657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f415c3f3dea49cb90ae12def4278f00.json"}}, {"family": "Katchamart", "given": "Wanruchada", "initials": "W", "orcid": "0000-0002-8952-5967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9439933b38fb49aca8fdbb5038ff603c.json"}}, {"family": "Goo", "given": "Phonpen Akarawatcharangura", "initials": "PA", "orcid": "0009-0009-7611-9992", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3979fce5848e46d2af71814d96ad0406.json"}}, {"family": "Shumnalieva", "given": "Russka", "initials": "R", "orcid": "0000-0003-2321-6536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/933232cd7feb48ee81b5971f01f52e23.json"}}, {"family": "Hoff", "given": "Leonardo Santos", "initials": "LS", "orcid": "0000-0002-2083-4796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1df7af8caf024ca39c57278fdf18c766.json"}}, {"family": "Kibbi", "given": "Lina El", "initials": "LE", "orcid": "0000-0003-1710-9996", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11bb4fc524264c6897dec9642a0ef7cd.json"}}, {"family": "Halabi", "given": "Hussein", "initials": "H", "orcid": "0000-0002-5174-8292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb337090a5ab4461a07e8620bee1b4b9.json"}}, {"family": "Vaidya", "given": "Binit", "initials": "B", "orcid": "0000-0002-4840-8924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b2296d53fe14fc7a8415f26e03e1944.json"}}, {"family": "Shaharir", "given": "Syahrul Sazliyana", "initials": "SS", "orcid": "0000-0002-9068-8114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1e6310979d44d58b548c61c733412af.json"}}, {"family": "Hasan", "given": "A T M Tanveer", "initials": "ATMT", "orcid": "0000-0002-5332-3319", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ffdb3329292438fac4005923ee79012.json"}}, {"family": "Dey", "given": "Dzifa", "initials": "D", "orcid": "0000-0002-3339-5112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2615e43aeba34a0585679bdd14a1a324.json"}}, {"family": "Guti\u00e9rrez", "given": "Carlos Enrique Toro", "initials": "CET", "orcid": "0000-0002-6084-7049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/980e455c5d114caaaefb6e0b55eaa3b3.json"}}, {"family": "Caballero-Uribe", "given": "Carlo V", "initials": "CV", "orcid": "0000-0002-9845-8620", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42d86c9923424f9a804bab4580b993c3.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "COVAD study group", "given": "", "initials": ""}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Rheumatol Int", "issn": "1437-160X", "issn-l": null, "volume": "43", "issue": "9", "pages": "1651-1664"}, "abstract": "Limited evidence on long-term COVID-19 vaccine safety in patients with idiopathic inflammatory myopathies (IIMs) continues to contribute to vaccine hesitancy. We studied delayed-onset vaccine adverse events (AEs) in patients with IIMs, other systemic autoimmune and inflammatory disorders (SAIDs), and healthy controls (HCs), using data from the second COVID-19 Vaccination in Autoimmune Diseases (COVAD) study. A validated self-reporting e-survey was circulated by the COVAD study group (157 collaborators, 106 countries) from Feb-June 2022. We collected data on demographics, comorbidities, IIM/SAID details, COVID-19 history, and vaccination details. Delayed-onset (> 7 day) AEs were analyzed using regression models. A total of 15165 respondents undertook the survey, of whom 8759 responses from vaccinated individuals [median age 46 (35-58) years, 74.4% females, 45.4% Caucasians] were analyzed. Of these, 1390 (15.9%) had IIMs, 50.6% other SAIDs, and 33.5% HCs. Among IIMs, 16.3% and 10.2% patients reported minor and major AEs, respectively, and 0.72% (n = 10) required hospitalization. Notably patients with IIMs experienced fewer minor AEs than other SAIDs, though rashes were expectedly more than HCs [OR 4.0; 95% CI 2.2-7.0, p < 0.001]. IIM patients with active disease, overlap myositis, autoimmune comorbidities, and ChadOx1 nCOV-19 (Oxford/AstraZeneca) recipients reported AEs more often, while those with inclusion body myositis, and BNT162b2 (Pfizer) recipients reported fewer AEs. Vaccination is reassuringly safe in individuals with IIMs, with AEs, hospitalizations comparable to SAIDs, and largely limited to those with autoimmune multimorbidity and active disease. These observations may inform guidelines to identify high-risk patients warranting close monitoring in the post-vaccination period.", "doi": "10.1007/s00296-023-05345-y", "pmid": "37351634", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10348925"}, {"db": "pii", "key": "10.1007/s00296-023-05345-y"}], "notes": [], "created": "2023-10-04T09:32:26.527Z", "modified": "2023-10-04T11:07:53.247Z"}, {"entity": "publication", "iuid": "29b8c3b876cf42b588d620c08f0cd89f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/29b8c3b876cf42b588d620c08f0cd89f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/29b8c3b876cf42b588d620c08f0cd89f"}}, "title": "Immune responses to SARS-CoV-2 infection and vaccination in children.", "authors": [{"family": "Brodin", "given": "Petter", "initials": "P"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Semin Immunol", "issn": "1096-3618", "issn-l": null, "volume": "69", "issue": null, "pages": "101794"}, "abstract": "During the three years since SARS-CoV-2 infections were first described a wealth of information has been gathered about viral variants and their changing properties, the disease presentations they elicit and how the many vaccines developed in record time protect from COVID-19 severe disease in different populations. A general theme throughout the pandemic has been the observation that children and young people in general fare well, with mild symptoms during acute infection and full recovery thereafter. It has also become clear that this is not universally true, as some children develop severe COVID-19 hypoxic pneumonia and even succumb to the infection, while another group of children develop a rare but serious multisystem inflammatory syndrome (MIS-C) and some other children experience prolonged illness following acute infection, post-COVID. Here I will discuss some of the findings made to explain these diverse disease manifestations in children and young people infected by SARS-CoV-2. I will also discuss the vaccines developed at record speed and their efficacy in protecting children from disease.", "doi": "10.1016/j.smim.2023.101794", "pmid": "37536147", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null, "Category: Vaccines": null, "Funder: H2020": null}, "xrefs": [{"db": "pmc", "key": "PMC10281229"}, {"db": "pii", "key": "S1044-5323(23)00085-4"}], "notes": [], "created": "2023-10-05T08:01:56.621Z", "modified": "2023-10-05T08:38:56.090Z"}, {"entity": "publication", "iuid": "0b24a4a644084329838bcebf6a5eb49b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b24a4a644084329838bcebf6a5eb49b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b24a4a644084329838bcebf6a5eb49b"}}, "title": "ISTH guidelines for antithrombotic treatment in COVID-19: Endorsement by the Scandinavian Society of Anaesthesiology and Intensive Care Medicine.", "authors": [{"family": "Chew", "given": "Michelle S", "initials": "MS", "orcid": "0000-0003-2888-4111", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c68391bb66e94be1ac0a14d69430666e.json"}}, {"family": "Olkkola", "given": "Klaus T", "initials": "KT"}, {"family": "Kalliom\u00e4ki", "given": "Maija-Liisa", "initials": "M"}, {"family": "Rehn", "given": "Marius", "initials": "M"}, {"family": "Sigur\u00f0sson", "given": "Martin Ingi", "initials": "MI"}, {"family": "M\u00f8ller", "given": "Morten Hylander", "initials": "MH", "orcid": "0000-0002-6378-9673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1cf88aaa5c9436a8e70ddfe39cfe4e8.json"}}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": "67", "issue": "8", "pages": "1118-1120"}, "abstract": "The Clinical Practice Committee of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine endorses the ISTH guidelines for antithrombotic treatment in COVID-19. This evidence-based guideline serves as a useful decision aid for Nordic anaesthesiologists caring for patients with COVID-19.", "doi": "10.1111/aas.14259", "pmid": "37318942", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:31:21.293Z", "modified": "2023-10-04T10:49:25.736Z"}, {"entity": "publication", "iuid": "e6045f02c1c24528984fafc7101ed0d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6045f02c1c24528984fafc7101ed0d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6045f02c1c24528984fafc7101ed0d0"}}, "title": "Home care nurses' and managers' work environment during the Covid-19 pandemic: Increased workload, competing demands, and unsustainable trade-offs.", "authors": [{"family": "Rydenf\u00e4lt", "given": "Christofer", "initials": "C"}, {"family": "Persson", "given": "Johanna", "initials": "J"}, {"family": "Erlingsd\u00f3ttir", "given": "Gudbj\u00f6rg", "initials": "G"}, {"family": "Larsson", "given": "Roger", "initials": "R"}, {"family": "Johansson", "given": "Gerd", "initials": "G"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Appl Ergon", "issn": "1872-9126", "issn-l": null, "volume": "111", "issue": null, "pages": "104056"}, "abstract": "Little research exists on how home care nursing personnel have experienced the Covid-19 pandemic. This qualitative study explores the work environment related challenges nurses and managers in home care faced during the pandemic. We discuss these challenges in relation to the Demand-Control-Support Model and reflect on how the organizational dynamics associated with them can be understood using the competing pressures model. During the pandemic, home care nurses and managers experienced both an increased workload and psychosocial strain. For managers, the increased complexity of work was a major problem. We identify three key takeaways related to sustainable crisis management: 1) to support managers' ability to provide social support to their personnel, 2) to increase crisis communication preparedness, and 3) to apply a holistic perspective on protective gear use. We also conclude that the competing pressures model is useful when exploring the dynamics of the work environment in complex organizational contexts.", "doi": "10.1016/j.apergo.2023.104056", "pmid": "37257218", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10230855"}, {"db": "pii", "key": "S0003-6870(23)00094-7"}], "notes": [], "created": "2023-10-04T05:11:54.494Z", "modified": "2023-10-04T07:22:54.879Z"}, {"entity": "publication", "iuid": "2ecacb0f4eee4ef999fdf3621d9fe9bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ecacb0f4eee4ef999fdf3621d9fe9bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ecacb0f4eee4ef999fdf3621d9fe9bd"}}, "title": "High-Density Lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner.", "authors": [{"family": "Correa", "given": "Yubexi", "initials": "Y"}, {"family": "Del Giudice", "given": "Rita", "initials": "R"}, {"family": "Waldie", "given": "Sarah", "initials": "S"}, {"family": "Th\u00e9paut", "given": "Michel", "initials": "M"}, {"family": "Micciula", "given": "Samantha", "initials": "S"}, {"family": "Gerelli", "given": "Yuri", "initials": "Y"}, {"family": "Moulin", "given": "Martine", "initials": "M"}, {"family": "Delaunay", "given": "Clara", "initials": "C"}, {"family": "Fieschi", "given": "Franck", "initials": "F"}, {"family": "Pichler", "given": "Harald", "initials": "H"}, {"family": "Haertlein", "given": "Michael", "initials": "M"}, {"family": "Forsyth", "given": "V Trevor", "initials": "VT"}, {"family": "Le Brun", "given": "Anton", "initials": "A"}, {"family": "Moir", "given": "Michael", "initials": "M"}, {"family": "Russell", "given": "Robert A", "initials": "RA"}, {"family": "Darwish", "given": "Tamim", "initials": "T"}, {"family": "Brinck", "given": "Jonas", "initials": "J"}, {"family": "Wodaje", "given": "Tigist", "initials": "T"}, {"family": "Jansen", "given": "Martin", "initials": "M"}, {"family": "Mart\u00edn", "given": "C\u00e9sar", "initials": "C"}, {"family": "Roosen-Runge", "given": "Felix", "initials": "F"}, {"family": "C\u00e1rdenas", "given": "Marit\u00e9", "initials": "M"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "J Colloid Interface Sci", "issn": "1095-7103", "issn-l": null, "volume": "645", "issue": null, "pages": "627-638"}, "abstract": "There is a close relationship between the SARS-CoV-2 virus and lipoproteins, in particular high-density lipoprotein (HDL). The severity of the coronavirus disease 2019 (COVID-19) is inversely correlated with HDL plasma levels. It is known that the SARS-CoV-2 spike (S) protein binds the HDL particle, probably depleting it of lipids and altering HDL function. Based on neutron reflectometry (NR) and the ability of HDL to efflux cholesterol from macrophages, we confirm these observations and further identify the preference of the S protein for specific lipids and the consequent effects on HDL function on lipid exchange ability. Moreover, the effect of the S protein on HDL function differs depending on the individuals lipid serum profile. Contrasting trends were observed for individuals presenting low triglycerides/high cholesterol serum levels (LTHC) compared to high triglycerides/high cholesterol (HTHC) or low triglycerides/low cholesterol serum levels (LTLC). Collectively, these results suggest that the S protein interacts with the HDL particle and, depending on the lipid profile of the infected individual, it impairs its function during COVID-19 infection, causing an imbalance in lipid metabolism.", "doi": "10.1016/j.jcis.2023.04.137", "pmid": "37167912", "labels": {"Category: Proteins": null, "Funder: VR": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10147446"}, {"db": "pii", "key": "S0021-9797(23)00736-1"}], "notes": [], "created": "2023-10-04T05:08:45.936Z", "modified": "2023-10-04T05:21:15.338Z"}, {"entity": "publication", "iuid": "3acca2f1e999419c83c69f0d31ced23d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3acca2f1e999419c83c69f0d31ced23d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3acca2f1e999419c83c69f0d31ced23d"}}, "title": "High seroprevalence of SARS-CoV-2 antibodies in healthcare workers in COVID-19 wards indicates an occupational hazard-a prospective cohort study during the first year of the COVID-19 pandemic in Kalmar County, Sweden.", "authors": [{"family": "Hultqvist", "given": "Viktor", "initials": "V"}, {"family": "Bonnedahl", "given": "Jonas", "initials": "J"}, {"family": "Edwardsson", "given": "Jonathan", "initials": "J"}, {"family": "Tjernberg", "given": "Ivar", "initials": "I"}, {"family": "Ryd\u00e9n", "given": "Ingvar", "initials": "I"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "APMIS", "issn": "1600-0463", "issn-l": null, "volume": "131", "issue": "9", "pages": "491-497"}, "abstract": "The aim of this study is to report the seroprevalence of SARS-CoV-2 antibodies in healthcare workers with various risk of occupational exposure in Kalmar County, Sweden, during the first year of the coronavirus disease 2019 (COVID-19) pandemic. We performed SARS-CoV-2 antibody measurements at four time points, from May 2020 to May 2021, in 401 healthcare workers (HCW) at seven hospital wards and two residential care facilities, with different risk of SARS-CoV-2 exposure. Overall, the prevalence of SARS-CoV-2 antibodies in HCW in Kalmar County was high compared to similar studies from other countries and increased from May 2020 to May 2021. Initially, 14% of the participants were SARS-CoV-2 seropositive. This number increased to 18% in September and 21% in December 2020. In May 2021, the prevalence of antibodies to nucleocapsid antigen had increased to 28%, while antibodies to spike protein had increased to 95% due to vaccination. A large variation in seroprevalence between different wards was detected and HCW in a COVID-19 designated ward had significantly higher seroprevalence than HCW working in wards without COVID-19 patients, with a risk ratio of 7.28, (95% CI 2.38-22.33) in May 2020. Our findings suggest a relationship between occupational COVID-19 exposure and seropositivity which implies that efficient hygiene routines for health- and social care workers are essential to avoid that COVID-19 care will constitute an occupational hazard.", "doi": "10.1111/apm.13343", "pmid": "37462243", "labels": {"Type: Journal article": null, "Category: Serology": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:07:30.080Z", "modified": "2023-10-04T12:15:22.937Z"}, {"entity": "publication", "iuid": "e75991c1750c4f7786ccf65e35dbb1fb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e75991c1750c4f7786ccf65e35dbb1fb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e75991c1750c4f7786ccf65e35dbb1fb"}}, "title": "High fatigue scores in patients with idiopathic inflammatory myopathies: a multigroup comparative study from the COVAD e-survey.", "authors": [{"family": "Grignaschi", "given": "Silvia", "initials": "S"}, {"family": "Kim", "given": "Minchul", "initials": "M", "orcid": "0000-0001-9737-6255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd2952c6167b4733bfbce019a162b310.json"}}, {"family": "Zanframundo", "given": "Giovanni", "initials": "G"}, {"family": "Ravichandran", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Kardes", "given": "Sinan", "initials": "S", "orcid": "0000-0002-6311-8634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2900c3ca00da476a8914574384a3c9c2.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "COVAD study group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Rheumatol Int", "issn": "1437-160X", "issn-l": null, "volume": "43", "issue": "9", "pages": "1637-1649"}, "abstract": "Idiopathic inflammatory myopathies (IIMs) confer a significant risk of disability and poor quality of life, though fatigue, an important contributing factor, remains under-reported in these individuals. We aimed to compare and analyze differences in visual analog scale (VAS) scores (0-10 cm) for fatigue (VAS-F) in patients with IIMs, non-IIM systemic autoimmune diseases (SAIDs), and healthy controls (HCs). We performed a cross-sectional analysis of the data from the COVID-19 Vaccination in Autoimmune Diseases (COVAD) international patient self-reported e-survey. The COVAD survey was circulated from December 2020 to August 2021, and details including demographics, COVID-19 history, vaccination details, SAID details, global health, and functional status were collected from adult patients having received at least one COVID-19 vaccine dose. Fatigue experienced 1 week prior to survey completion was assessed using a single-item 10 cm VAS. Determinants of fatigue were analyzed in regression models. Six thousand nine hundred and eighty-eight respondents (mean age 43.8 years, 72% female; 55% White) were included in the analysis. The overall VAS-F score was 3 (IQR 1-6). Patients with IIMs had similar fatigue scores (5, IQR 3-7) to non-IIM SAIDs [5 (IQR 2-7)], but higher compared to HCs (2, IQR 1-5; P < 0.001), regardless of disease activity. In adjusted analysis, higher VAS-F scores were seen in females (reference female; coefficient -0.17; 95%CI -0.21 to -13; P < 0.001) and Caucasians (reference Caucasians; coefficient -0.22; 95%CI -0.30 to -0.14; P < 0.001 for Asians and coefficient -0.08; 95%CI -0.13 to 0.30; P = 0.003 for Hispanics) in our cohort. Our study found that patients with IIMs exhibit considerable fatigue, similar to other SAIDs and higher than healthy individuals. Women and Caucasians experience greater fatigue scores, allowing identification of stratified groups for optimized multidisciplinary care and improve outcomes such as quality of life.", "doi": "10.1007/s00296-023-05344-z", "pmid": "37314497", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Funder: H2020": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10265550"}, {"db": "pii", "key": "10.1007/s00296-023-05344-z"}], "notes": [], "created": "2023-10-04T09:32:31.580Z", "modified": "2023-10-04T11:09:52.683Z"}, {"entity": "publication", "iuid": "bf31b0ac62cb410db050e9b0a752e1aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf31b0ac62cb410db050e9b0a752e1aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf31b0ac62cb410db050e9b0a752e1aa"}}, "title": "Exploring the learning needs of clinicians in Belgium and Sweden regarding prone positioning and skin damage prevention: A qualitative study.", "authors": [{"family": "Fourie", "given": "Anika", "initials": "A"}, {"family": "Karlberg-Traav", "given": "Malin", "initials": "M"}, {"family": "Dahlberg", "given": "Karuna", "initials": "K"}, {"family": "Hanssens", "given": "Valerie", "initials": "V"}, {"family": "Smet", "given": "Steven", "initials": "S"}, {"family": "Jaensson", "given": "Maria", "initials": "M"}, {"family": "Beeckman", "given": "Dimitri", "initials": "D"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Nurse Educ Today", "issn": "1532-2793", "issn-l": null, "volume": "128", "issue": null, "pages": "105860"}, "abstract": "During the coronavirus pandemic (COVID -19), the use of prone positioning in critically ill patients with acute respiratory distress syndrome (ARDS) increased substantially. As a result, clinicians had to (re)learn how to treat the patient in the prone position while preventing adverse events such as pressure ulcers, skin tears and moisture-associated skin damage.\r\n\r\nThe purpose of the study was to determine participants' learning needs related to patients in the prone position and the prevention of skin damage, such as pressure ulcers, and what they perceived as a positive or negative learning experience.\r\n\r\nThis study used a qualitative methodological framework and employed an exploratory design.\r\n\r\nA purposive sample of clinicians (n = 20) with direct or indirect work experience with prone ventilated patients was recruited in Belgium and Sweden.\r\n\r\nIndividual semi-structured interviews were conducted in Belgium and Sweden between February and August 2022. Data were analysed thematically using an inductive approach. The COREQ guideline was utilised to comprehensively report on the study.\r\n\r\nTwo themes were identified: 'Adapting to a crisis' and 'How to learn', with the latter having two subthemes: 'balancing theory and practice' and 'co-creating knowledge'. Unexpected circumstances necessitated a personal adaption, a change in learning methods and a pragmatic adaptation of protocols, equipment and working procedures. Participants recognised a multifaceted educational approach which would contribute to a positive learning experience regarding prone positioning and skin damage prevention. The importance of poising theoretical teaching with practical hands-on training was highlighted with an emphasis on interaction, discussion, and networking between peers.\r\n\r\nThe study findings highlight learning approaches which may help inform the development of befitting educational resources for clinicians. Prone therapy for ARDS patients is not limited to the pandemic. Therefore, educational efforts should continue to ensure patient safety in this important area.", "doi": "10.1016/j.nedt.2023.105860", "pmid": "37302346", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10245459"}, {"db": "pii", "key": "S0260-6917(23)00154-5"}], "notes": [], "created": "2023-10-04T09:33:11.219Z", "modified": "2023-10-04T11:19:39.322Z"}, {"entity": "publication", "iuid": "84557420b4864451a9d76aff69578f14", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84557420b4864451a9d76aff69578f14.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84557420b4864451a9d76aff69578f14"}}, "title": "Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2.", "authors": [{"family": "Yang", "given": "Pei-Pei", "initials": "P"}, {"family": "Ye", "given": "Xin-Wei", "initials": "X"}, {"family": "Liu", "given": "Mei-Qin", "initials": "M"}, {"family": "Yang", "given": "Jin-Xuan", "initials": "J"}, {"family": "Feng", "given": "Xiao-Li", "initials": "X"}, {"family": "Li", "given": "Yi-Jing", "initials": "Y"}, {"family": "Zhang", "given": "Kuo", "initials": "K"}, {"family": "Liang", "given": "Hong-Wen", "initials": "H"}, {"family": "Yi", "given": "Yu", "initials": "Y"}, {"family": "Wang", "given": "Lei", "initials": "L", "orcid": "0000-0003-1405-9815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30c6dba79ded4fd1b628ddfd5daf494f.json"}}, {"family": "Liu", "given": "Yi-Xuan", "initials": "Y"}, {"family": "Yang", "given": "Xing-Lou", "initials": "X"}, {"family": "Shi", "given": "Zheng-Li", "initials": "Z"}, {"family": "Feng", "given": "Li-Qiang", "initials": "L"}, {"family": "Chen", "given": "Ling", "initials": "L"}, {"family": "Xue", "given": "Yintong", "initials": "Y"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}, {"family": "Wang", "given": "Hao", "initials": "H"}, {"family": "Zhao", "given": "Yuliang", "initials": "Y"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Adv Healthc Mater", "issn": "2192-2659", "issn-l": null, "volume": "12", "issue": "24", "pages": "e2300673"}, "abstract": "The viral spike (S) protein on the surface of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin-converting enzyme 2 (ACE2) receptors on the host cells, facilitating its entry and infection. Here, functionalized nanofibers targeting the S protein with peptide sequences of IRQFFKK, WVHFYHK and NSGGSVH, which are screened from a high-throughput one-bead one-compound screening strategy, are designed and prepared. The flexible nanofibers support multiple binding sites and efficiently entangle SARS-CoV-2, forming a nanofibrous network that blocks the interaction between the S protein of SARS-CoV-2 and the ACE2 on host cells, and efficiently reduce the invasiveness of SARS-CoV-2. In summary, nanofibers entangling represents a smart nanomedicine for the prevention of SARS-CoV-2.", "doi": "10.1002/adhm.202300673", "pmid": "37139567", "labels": {"Category: Proteins": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:11:52.046Z", "modified": "2023-10-04T07:22:10.555Z"}, {"entity": "publication", "iuid": "4ec4a4b1a1fc4bcda2fabd8ba091ed1b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ec4a4b1a1fc4bcda2fabd8ba091ed1b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ec4a4b1a1fc4bcda2fabd8ba091ed1b"}}, "title": "Digital health funding for COVID-19 vaccine deployment across four major donor agencies.", "authors": [{"family": "Helld\u00e9n", "given": "Daniel", "initials": "D"}, {"family": "Tesfaye", "given": "Sophia", "initials": "S"}, {"family": "Gachen", "given": "Carine", "initials": "C"}, {"family": "Lindstrand", "given": "Ann", "initials": "A"}, {"family": "K\u00e4llander", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "The Lancet Digital Health", "issn": "2589-7500", "issn-l": null, "volume": "5", "issue": "9", "pages": "e627-e631"}, "abstract": "The international response to the COVID-19 pandemic provided opportunities for countries to use digital technologies for vaccine deployment and associated activities, but misaligned digital investments could weaken or fragment national systems. In this review of 311 funding applications from 120 country governments to four donor agencies (UNICEF; Gavi, the Vaccine Alliance; the Global Fund to Fight AIDS, Tuberculosis and Malaria; and the World Bank) up to May 1, 2022, we found that 272 (87%) of the applications included at least one digital aspect and that substantial funding has been dedicated towards digital aspects from donors. The majority of digital aspects concerned immunisation information systems, vaccine acceptance and uptake, and COVID-19 surveillance. As the global community sets its sights on a COVID-19-free world, continued coordinated investments in digital health and health information systems for pandemic preparedness and response will be key to strengthening the resilience of health systems.", "doi": "10.1016/S2589-7500(23)00134-6", "pmid": "37625897", "labels": {"Category: Other": null, "Category: Vaccines": null, "Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2589-7500(23)00134-6"}], "notes": [], "created": "2023-10-05T08:08:39.770Z", "modified": "2023-10-06T04:31:10.944Z"}, {"entity": "publication", "iuid": "63b101b848ae4630a61c9b89c8877dcf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63b101b848ae4630a61c9b89c8877dcf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63b101b848ae4630a61c9b89c8877dcf"}}, "title": "Cognitive ability, health policy, and the dynamics of COVID-19 vaccination.", "authors": [{"family": "Elinder", "given": "Mikael", "initials": "M"}, {"family": "Erixson", "given": "Oscar", "initials": "O"}, {"family": "\u00d6hman", "given": "Mattias", "initials": "M"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "J Health Econ", "issn": "1879-1646", "issn-l": null, "volume": "91", "issue": null, "pages": "102802"}, "abstract": "We examine the relationship between cognitive ability and prompt COVID-19 vaccination using individual-level data on more than 700,000 individuals in Sweden. We find a strong positive association between cognitive ability and swift vaccination, which remains even after controlling for confounding variables with a twin-design. The results suggest that the complexity of the vaccination decision may make it difficult for individuals with lower cognitive abilities to understand the benefits of vaccination. Consistent with this, we show that simplifying the vaccination decision through pre-booked vaccination appointments alleviates almost all of the inequality in vaccination behavior.", "doi": "10.1016/j.jhealeco.2023.102802", "pmid": "37672962", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0167-6296(23)00079-6"}], "notes": [], "created": "2023-10-06T06:56:51.941Z", "modified": "2023-10-06T11:31:47.711Z"}, {"entity": "publication", "iuid": "a7e27207e7a94cd8aff08881f2864f65", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7e27207e7a94cd8aff08881f2864f65.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7e27207e7a94cd8aff08881f2864f65"}}, "title": "A standardised protocol for relative SARS-CoV-2 variant severity assessment, applied to Omicron BA.1 and Delta in six European countries, October 2021 to February 2022.", "authors": [{"family": "Nyberg", "given": "Tommy", "initials": "T"}, {"family": "Bager", "given": "Peter", "initials": "P"}, {"family": "Svalgaard", "given": "Ingrid Bech", "initials": "IB"}, {"family": "Bejko", "given": "Dritan", "initials": "D"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Evans", "given": "Josie", "initials": "J"}, {"family": "Krause", "given": "Tyra Grove", "initials": "TG"}, {"family": "McMenamin", "given": "Jim", "initials": "J"}, {"family": "Mossong", "given": "Jo\u00ebl", "initials": "J"}, {"family": "Mutch", "given": "Heather", "initials": "H"}, {"family": "Omokanye", "given": "Ajibola", "initials": "A"}, {"family": "Peralta-Santos", "given": "Andr\u00e9", "initials": "A"}, {"family": "Pinto-Leite", "given": "Pedro", "initials": "P"}, {"family": "Starrfelt", "given": "Jostein", "initials": "J"}, {"family": "Thelwall", "given": "Simon", "initials": "S"}, {"family": "Veneti", "given": "Lamprini", "initials": "L"}, {"family": "Whittaker", "given": "Robert", "initials": "R"}, {"family": "Wood", "given": "John", "initials": "J"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "Presanis", "given": "Anne M", "initials": "AM"}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "36", "pages": null}, "abstract": "Several SARS-CoV-2 variants that evolved during the COVID-19 pandemic have appeared to differ in severity, based on analyses of single-country datasets. With decreased testing and sequencing, international collaborative studies will become increasingly important for timely assessment of the severity of new variants. Therefore, a joint WHO Regional Office for Europe and ECDC working group was formed to produce and pilot a standardised study protocol to estimate relative case-severity of SARS-CoV-2 variants during periods when two variants were co-circulating. The study protocol and its associated statistical analysis code was applied by investigators in Denmark, England, Luxembourg, Norway, Portugal and Scotland to assess the severity of cases with the Omicron BA.1 virus variant relative to Delta. After pooling estimates using meta-analysis methods (random effects estimates), the risk of hospital admission (adjusted hazard ratio (aHR) = 0.41; 95% confidence interval (CI): 0.31-0.54), admission to intensive care unit (aHR = 0.12; 95% CI: 0.05-0.27) and death (aHR = 0.31; 95% CI: 0.28-0.35) was lower for Omicron BA.1 compared with Delta cases. The aHRs varied by age group and vaccination status. In conclusion, this study demonstrates the feasibility of conducting variant severity analyses in a multinational collaborative framework and adds evidence for the reduced severity of the Omicron BA.1 variant.", "doi": "10.2807/1560-7917.ES.2023.28.36.2300048", "pmid": "37676146", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10486193"}], "notes": [], "created": "2023-10-06T06:55:12.366Z", "modified": "2023-10-06T10:47:20.690Z"}, {"entity": "publication", "iuid": "4e8767b8b6054dbeaab6dfe907ae7b97", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4e8767b8b6054dbeaab6dfe907ae7b97.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4e8767b8b6054dbeaab6dfe907ae7b97"}}, "title": "A randomised phase 2a study to investigate the effects of blocking interleukin-33 with tozorakimab in patients hospitalised with COVID-19: ACCORD-2.", "authors": [{"family": "Wilkinson", "given": "Tom", "initials": "T", "orcid": "0000-0003-1771-3851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3239563fcce145ee8d4ab7d35b43a2ad.json"}}, {"family": "De Soyza", "given": "Anthony", "initials": "A", "orcid": "0000-0002-8566-0344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1dc6ec2385014db6aad8bbd5a246ed68.json"}}, {"family": "Carroll", "given": "Miles", "initials": "M", "orcid": "0000-0002-7026-7187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d55790d02914f88a2df413b99c59749.json"}}, {"family": "Chalmers", "given": "James D", "initials": "JD", "orcid": "0000-0001-5514-7868", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37d2cc32f79448a28df83f9ee728cac3.json"}}, {"family": "Crooks", "given": "Michael G", "initials": "MG"}, {"family": "Griffiths", "given": "Gareth", "initials": "G"}, {"family": "Shankar-Hari", "given": "Manu", "initials": "M", "orcid": "0000-0002-5338-2538", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/490ca05f76804685bf9fec3adfa0b0a0.json"}}, {"family": "Ho", "given": "Ling-Pei", "initials": "L"}, {"family": "Horsley", "given": "Alex", "initials": "A", "orcid": "0000-0003-1828-0058", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/088d99884f4642dab5297a7864ef1fe1.json"}}, {"family": "Kell", "given": "Chris", "initials": "C"}, {"family": "Lara", "given": "Beatriz", "initials": "B", "orcid": "0000-0003-0090-8206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d115da5d1e0246af8f08f70a4e9266c4.json"}}, {"family": "Mishra", "given": "Biswa", "initials": "B"}, {"family": "Moate", "given": "Rachel", "initials": "R"}, {"family": "Page", "given": "Clive", "initials": "C"}, {"family": "Pandya", "given": "Hitesh", "initials": "H"}, {"family": "Raw", "given": "Jason", "initials": "J"}, {"family": "Reid", "given": "Fred", "initials": "F"}, {"family": "Saralaya", "given": "Dinesh", "initials": "D"}, {"family": "Scott", "given": "Ian C", "initials": "IC"}, {"family": "Siddiqui", "given": "Salman", "initials": "S"}, {"family": "Ustianowski", "given": "Andy", "initials": "A"}, {"family": "van Zuydam", "given": "Natalie", "initials": "N"}, {"family": "Woodcock", "given": "Ashley", "initials": "A", "orcid": "0000-0002-5428-8578", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d3fb0de3ce5b4352876837cd518b332a.json"}}, {"family": "Singh", "given": "Dave", "initials": "D", "orcid": "0000-0001-8918-7075", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f87ffcbf55547c7832731e3479d55bd.json"}}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "ERJ Open Res", "issn": "2312-0541", "issn-l": null, "volume": "9", "issue": "5", "pages": null}, "abstract": "Increased serum interleukin (IL)-33 predicts poor outcomes in patients hospitalised with coronavirus disease 2019 (COVID-19). We examined the efficacy and safety of tozorakimab, a monoclonal antibody that neutralises IL-33, in improving outcomes in ACCORD-2 (EudraCT: 2020-001736-95).\r\n\r\nACCORD-2 was an open-label, phase 2a study in adults hospitalised with COVID-19. Patients were randomised 1:1 to tozorakimab 300 mg plus standard of care (SoC) or SoC alone. The primary end-point was time to clinical response (sustained clinical improvement of \u22652 points on the World Health Organization ordinal scale, discharge from hospital or fit for discharge) by day 29. Other end-points included death or respiratory failure, mortality and intensive care unit admission by day 29, and safety. Serum IL-33/soluble stimulated-2 (sST2) complex levels were measured by high-sensitivity immunoassay.\r\n\r\nEfficacy analyses included 97 patients (tozorakimab+SoC, n=53; SoC, n=44). Median time to clinical response did not differ between the tozorakimab and SoC arms (8.0 and 9.5 days, respectively; HR 0.96, 80% CI 0.70-1.31; one-sided p=0.33). Tozorakimab was well tolerated and the OR for risk of death or respiratory failure with treatment versus SoC was 0.55 (80% CI 0.27-1.12; p=0.26), while the OR was 0.31 (80% CI 0.09-1.06) in patents with high baseline serum IL-33/sST2 complex levels.\r\n\r\nOverall, ACCORD-2 results suggest that tozorakimab could be a novel therapy for patients hospitalised with COVID-19, warranting further investigation in confirmatory phase 3 studies.", "doi": "10.1183/23120541.00249-2023", "pmid": "37868151", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10588785"}, {"db": "pii", "key": "00249-2023"}], "notes": [], "created": "2023-11-01T13:34:04.363Z", "modified": "2023-11-02T07:40:47.429Z"}, {"entity": "publication", "iuid": "0253ecf537a940588afeebc1bcd7406c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0253ecf537a940588afeebc1bcd7406c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0253ecf537a940588afeebc1bcd7406c"}}, "title": "Alcohol consumption under lockdown measures during the COVID-19 pandemic in three Nordic countries.", "authors": [{"family": "Gunnerlind", "given": "Oscar", "initials": "O", "orcid": "0000-0003-2856-0192", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd5a54cbaeee4a89932f208c10fd5d0a.json"}}, {"family": "Lundqvist", "given": "Robert", "initials": "R"}, {"family": "Ott", "given": "Michael", "initials": "M"}, {"family": "Werneke", "given": "Ursula", "initials": "U", "orcid": "0000-0002-5023-3254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eed3b002ddb4cbba141cbfdc8d3f032.json"}}], "type": "journal article", "published": "2023-08-31", "journal": {"title": "Int J Soc Psychiatry", "issn": "1741-2854", "issn-l": null, "volume": null, "issue": null, "pages": "207640231194486"}, "abstract": "At the beginning of the COVID-19 pandemic, concerns arose about a possible rise in alcohol consumption. Early surveys, however, more commonly pointed towards a decrease of alcohol use. But studies based on self-reports may underestimate alcohol use. They also depend on the population sampled. Because of border closures and gastronomy restrictions, countries with centralised alcohol sales provided a unique opportunity to study total domestic consumption during the pandemic without influence of private import or reliance on self-reports.\r\n\r\nWe examined the correlation between alcohol sales and national COVID-19 restrictions in three such countries, Finland, Norway and Sweden.\r\n\r\nWe conducted this study as a mirror image study, comparing alcohol sales during the first 2 years of the COVID-19 pandemic with the two preceding years. We explored hours of daylight/season as potential confounders.\r\n\r\nWe found no relevant change in alcohol sales during the pandemic years for Finland or Sweden. For Norway, there was a level-change in sales, which could be explained by decreased imports. Sales followed a seasonal pattern. In all three countries, the initial pandemic increase in alcohol sales coincided with an underlying annually recurring seasonal variation.\r\n\r\nThe COVID-19 pandemic had less of an impact on alcohol consumption in the three Nordic countries than could intuitively be expected. The increase of alcohol sales at the beginning of the COVID-19 pandemic coincided with a seasonal rise following a pre-pandemic pattern. Therefore, caution should be exercised with drawing conclusions from data with a short time perspective to avoid attribution bias.", "doi": "10.1177/00207640231194486", "pmid": "37650471", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:02:41.240Z", "modified": "2023-10-05T08:49:41.393Z"}, {"entity": "publication", "iuid": "659e1b32ed7d47b7a951e42b964496a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/659e1b32ed7d47b7a951e42b964496a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/659e1b32ed7d47b7a951e42b964496a6"}}, "title": "Addressing health inequity during the COVID-19 pandemic through primary health care and public health collaboration: a multiple case study analysis in eight high-income countries.", "authors": [{"family": "Vanden Bossche", "given": "Dorien", "initials": "D"}, {"family": "Zhao", "given": "Q Jane", "initials": "QJ"}, {"family": "Ares-Blanco", "given": "Sara", "initials": "S"}, {"family": "Pe\u00f1a", "given": "Maria Pilar Astier", "initials": "MPA"}, {"family": "Decat", "given": "Peter", "initials": "P"}, {"family": "Kondo", "given": "Naoki", "initials": "N"}, {"family": "Kroneman", "given": "Madelon", "initials": "M"}, {"family": "Nishioka", "given": "Daisuke", "initials": "D"}, {"family": "Petrazzuoli", "given": "Ferdinando", "initials": "F"}, {"family": "Rortveit", "given": "Guri", "initials": "G"}, {"family": "Schaubroeck", "given": "Emmily", "initials": "E"}, {"family": "Stark", "given": "Stefanie", "initials": "S"}, {"family": "Pinto", "given": "Andrew D", "initials": "AD"}, {"family": "Willems", "given": "Sara", "initials": "S"}], "type": "journal article", "published": "2023-08-31", "journal": {"title": "Int J Equity Health", "issn": "1475-9276", "issn-l": null, "volume": "22", "issue": "1", "pages": "171"}, "abstract": "The COVID-19 pandemic substantially magnified the inequity gaps among vulnerable populations. Both public health (PH) and primary health care (PHC) have been crucial in addressing the challenges posed by the pandemic, especially in the area of vulnerable populations. However, little is known about the intersection between PH and PHC as a strategy to mitigate the inequity gap. This study aims to assess the collaboration between PHC and PH with a focus on addressing the health needs of vulnerable populations during the COVID-19 pandemic across jurisdictions.\r\n\r\nWe analyzed and compared data from jurisdictional reports of COVID-19 pandemic responses in PHC and PH in Belgium, Canada (Ontario), Germany, Italy, Japan, the Netherlands, Norway, and Spain from 2020 to 2021.\r\n\r\nFour themes emerge from the analysis: (1) the majority of the countries implemented outreach strategies targeting vulnerable groups as a means to ensure continued access to PHC; (2) digital assessment in PHC was found to be present across all the countries; (3) PHC was insufficiently represented at the decision-making level; (4) there is a lack of clear communication channels between PH and PHC in all the countries.\r\n\r\nThis study identified opportunities for collaboration between PHC and PH to reduce inequity gaps and to improve population health, focusing on vulnerable populations. The COVID-19 response in these eight countries has demonstrated the importance of an integrated PHC system. Consequently, the development of effective strategies for responding to and planning for pandemics should take into account the social determinants of health in order to mitigate the unequal impact of COVID-19. Careful, intentional coordination between PH and PHC should be established in normal times as a basis for effective response during future public health emergencies. The pandemic has provided significant insights on how to strengthen health systems and provide universal access to healthcare by fostering stronger connections between PH and PHC.", "doi": "10.1186/s12939-023-01968-6", "pmid": "37653472", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10472729"}, {"db": "pii", "key": "10.1186/s12939-023-01968-6"}], "notes": [], "created": "2023-10-06T06:56:38.772Z", "modified": "2023-10-06T11:24:37.724Z"}, {"entity": "publication", "iuid": "f434c2ddde2e47c7b06209913c57337d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f434c2ddde2e47c7b06209913c57337d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f434c2ddde2e47c7b06209913c57337d"}}, "title": "Super-resolution proximity labeling reveals anti-viral protein network and its structural changes against SARS-CoV-2 viral proteins.", "authors": [{"family": "Lee", "given": "Yun-Bin", "initials": "Y"}, {"family": "Jung", "given": "Minkyo", "initials": "M"}, {"family": "Kim", "given": "Jeesoo", "initials": "J"}, {"family": "Charles", "given": "Afandi", "initials": "A"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Kang", "given": "Jiwoong", "initials": "J"}, {"family": "Kang", "given": "Myeong-Gyun", "initials": "M"}, {"family": "Kwak", "given": "Chulhwan", "initials": "C"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Kim", "given": "Jong-Seo", "initials": "J"}, {"family": "Mun", "given": "Ji Young", "initials": "JY"}, {"family": "Rhee", "given": "Hyun-Woo", "initials": "H"}], "type": "journal article", "published": "2023-08-29", "journal": {"title": "Cell Rep", "issn": "2211-1247", "issn-l": null, "volume": "42", "issue": "8", "pages": "112835"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in human cells by interacting with host factors following infection. To understand the virus and host interactome proximity, we introduce a super-resolution proximity labeling (SR-PL) method with a \"plug-and-playable\" PL enzyme, TurboID-GBP (GFP-binding nanobody protein), and we apply it for interactome mapping of SARS-CoV-2 ORF3a and membrane protein (M), which generates highly perturbed endoplasmic reticulum (ER) structures. Through SR-PL analysis of the biotinylated interactome, 224 and 272 peptides are robustly identified as ORF3a and M interactomes, respectively. Within the ORF3a interactome, RNF5 co-localizes with ORF3a and generates ubiquitin modifications of ORF3a that can be involved in protein degradation. We also observe that the SARS-CoV-2 infection rate is efficiently reduced by the overexpression of RNF5 in host cells. The interactome data obtained using the SR-PL method are presented at https://sarscov2.spatiomics.org. We hope that our method will contribute to revealing virus-host interactions of other viruses in an efficient manner.", "doi": "10.1016/j.celrep.2023.112835", "pmid": "37478010", "labels": {"Type: Journal article": null, "Category: Proteins": null}, "xrefs": [{"db": "pii", "key": "S2211-1247(23)00846-X"}], "notes": [], "created": "2023-10-04T12:10:26.384Z", "modified": "2023-10-04T13:13:13.239Z"}, {"entity": "publication", "iuid": "90c3a6e606bf4d3ca62e2f8c6def2741", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90c3a6e606bf4d3ca62e2f8c6def2741.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90c3a6e606bf4d3ca62e2f8c6def2741"}}, "title": "Prepandemic personal concentrations of per- and polyfluoroalkyl substances (PFAS) and other pollutants: Specific and combined effects on the incidence of COVID-19 disease and SARS-CoV-2 infection.", "authors": [{"family": "Pumarega", "given": "Jos\u00e9", "initials": "J"}, {"family": "Gasull", "given": "Magda", "initials": "M"}, {"family": "Koponen", "given": "Jani", "initials": "J"}, {"family": "Campi", "given": "Laura", "initials": "L"}, {"family": "Rantakokko", "given": "Panu", "initials": "P"}, {"family": "Henr\u00edquez-Hern\u00e1ndez", "given": "Luis A", "initials": "LA"}, {"family": "Aguilar", "given": "Ruth", "initials": "R"}, {"family": "Donat-Vargas", "given": "Carolina", "initials": "C"}, {"family": "Zumbado", "given": "Manuel", "initials": "M"}, {"family": "Villar-Garc\u00eda", "given": "Judit", "initials": "J"}, {"family": "Rius", "given": "Cristina", "initials": "C"}, {"family": "Santiago-D\u00edaz", "given": "Pablo", "initials": "P"}, {"family": "Vidal", "given": "Marta", "initials": "M"}, {"family": "Jimenez", "given": "Alfons", "initials": "A"}, {"family": "Iglesias", "given": "Mar", "initials": "M"}, {"family": "Doba\u00f1o", "given": "Carlota", "initials": "C"}, {"family": "Moncunill", "given": "Gemma", "initials": "G"}, {"family": "Porta", "given": "Miquel", "initials": "M"}], "type": "journal article", "published": "2023-08-29", "journal": {"title": "Environ Res", "issn": "1096-0953", "issn-l": "0013-9351", "volume": "237", "issue": "Pt 2", "pages": "116965"}, "abstract": "To investigate the specific and combined effects of personal concentrations of some per- and polyfluoroalkyl substances (PFAS), other persistent organic pollutants (POPs), and chemical elements -measured in individuals' blood several years before the pandemic- on the development of SARS-CoV-2 infection and COVID-19 disease in the general population.\r\n\r\nWe conducted a prospective cohort study in 240 individuals from the general population of Barcelona. PFAS, other POPs, and chemical elements were measured in plasma, serum, and whole blood samples, respectively, collected in 2016-2017. PFAS were analyzed by liquid chromatography-triple quadrupole mass spectrometry. SARS-CoV-2 infection was detected by rRT-PCR in nasopharyngeal swabs and/or antibody serology in blood samples collected in 2020-2021.\r\n\r\nNo individual PFAS nor their mixtures were significantly associated with SARS-CoV-2 seropositivity or COVID-19 disease. Previously identified mixtures of POPs and elements (Porta et al., 2023) remained significantly associated with seropositivity and COVID-19 when adjusted for PFAS (all OR > 4 or p < 0.05). Nine chemicals comprised mixtures associated with COVID-19: thallium, ruthenium, lead, benzo[b]fluoranthene, DDD, other DDT-related compounds, manganese, tantalum, and aluminium. And nine chemicals comprised the mixtures more consistently associated with SARS-CoV-2 seropositivity: thallium, ruthenium, lead, benzo[b]fluoranthene, DDD, gold, and (protectively) selenium, indium, and iron.\r\n\r\nThe PFAS studied were not associated with SARS-CoV-2 seropositivity or COVID-19. The results confirm the associations between personal blood concentrations of some POPs and chemical elements and the risk of COVID-19 and SARS-CoV-2 infection in what remains the only prospective and population-based cohort study on the topic. Mixtures of POPs and chemical elements may contribute to explain the heterogeneity in the risks of SARS-CoV-2 infection and COVID-19 in the general population.", "doi": "10.1016/j.envres.2023.116965", "pmid": "37652221", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0013-9351(23)01769-3"}], "notes": [], "created": "2023-10-06T06:52:13.472Z", "modified": "2023-10-06T08:27:52.331Z"}, {"entity": "publication", "iuid": "670370e2a10447ef97d64d892dc77928", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/670370e2a10447ef97d64d892dc77928.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/670370e2a10447ef97d64d892dc77928"}}, "title": "Long-term survival after intensive care for COVID-19: a nationwide cohort study of more than 8000 patients.", "authors": [{"family": "H\u00e4ggl\u00f6f", "given": "Elsa", "initials": "E", "orcid": "0000-0001-7741-8980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9298066f63df45aaa4ce3d8b54d14fb6.json"}}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "Zettersten", "given": "Erik", "initials": "E"}, {"family": "Engerstr\u00f6m", "given": "Lars", "initials": "L"}, {"family": "Larsson", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2023-08-29", "journal": {"title": "Ann Intensive Care", "issn": "2110-5820", "issn-l": null, "volume": "13", "issue": "1", "pages": "76"}, "abstract": "Was it worth it-what is the outcome after the extended ICU (intensive care unit) length of stay for COVID-19 patients? Surprisingly, data on long-term mortality in large cohorts are lacking. We investigate long-term mortality including differences between men and women, as previous studies show that men generally suffer a more severe course of COVID-19 in terms of severity of illness and short-term mortality.\r\n\r\nNationwide cohort including all adult COVID-19 patients admitted to Swedish ICUs until August 12, 2022. Primary outcome was 360-day mortality after ICU admission. Logistic regression was used to estimate associations between demographics, comorbidities, clinical characteristics and mortality.\r\n\r\nIn total, 8392 patients were included. Median (IQR) age was 63 (52-72) years and the majority (70.1%) were men. Among the 7390 patients with complete 360-day mortality data, 1775 (24.4%) patients died within 30 days, 2125 (28.8%) within 90 days and 2206 (29.8%) within 360 days from ICU admission. 360-day mortality was 27.1% in women and 31.0% in men. Multivariable logistic regression analysis showed increased risk of 360-day mortality in men compared to women (OR: 1.33, 95% CI: 1.17-1.52). Other variables associated with poor 360-day mortality were age, cardiac disease, COPD/asthma, diabetes, immune deficiency, chronic kidney disease, neuromuscular disease, and malignancy.\r\n\r\nThis study confirms the increased severity of disease in critically ill men with COVID-19, even in a long-term perspective. However, mortality beyond 90 days was strikingly low, indicating high probability of survival after the acute phase of illness.", "doi": "10.1186/s13613-023-01156-3", "pmid": "37642833", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC10465451"}, {"db": "pii", "key": "10.1186/s13613-023-01156-3"}], "notes": [], "created": "2023-10-05T08:08:34.880Z", "modified": "2023-10-05T08:54:18.433Z"}, {"entity": "publication", "iuid": "4915a33bdda740cda0a5c21e21012377", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4915a33bdda740cda0a5c21e21012377.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4915a33bdda740cda0a5c21e21012377"}}, "title": "Impact of Risk Factors on COVID-19 Outcomes in Unvaccinated People with Rheumatic Diseases.", "authors": [{"family": "Yazdany", "given": "Jinoos", "initials": "J", "orcid": "0000-0002-3508-4094", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62bbeb3392ce40d482da768af63f5d54.json"}}, {"family": "Ware", "given": "Anna", "initials": "A", "orcid": "0000-0003-3333-7833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6be3cbe46a3b4190a31e190c195f7e77.json"}}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Grainger", "given": "Rebecca", "initials": "R", "orcid": "0000-0001-9201-8678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9d304e9e29a43a5a7a76679c002a876.json"}}, {"family": "Hachulla", "given": "Eric", "initials": "E"}, {"family": "Richez", "given": "Christophe", "initials": "C"}, {"family": "Cacoub", "given": "Patrice", "initials": "P", "orcid": "0000-0002-6727-4992", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fc3b4f8d7994a7fb48f3facfa27baf8.json"}}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS", "orcid": "0000-0003-0786-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d99dc166f48d4af7b8e46dc999c7444b.json"}}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Jacobsohn", "given": "Lindsay", "initials": "L"}, {"family": "Strangfeld", "given": "Anja", "initials": "A"}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL"}, {"family": "Gossec", "given": "Laure", "initials": "L"}, {"family": "Carmona", "given": "Loreto", "initials": "L"}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S", "orcid": "0000-0002-8611-162X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73b17eb08d984421847f733b7a6a49d4.json"}}, {"family": "Kearsley-Fleet", "given": "Lianne", "initials": "L", "orcid": "0000-0003-0377-1575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9cc64aac266462baf67998b3d49c6f7.json"}}, {"family": "Schaefer", "given": "Martin", "initials": "M", "orcid": "0000-0001-6487-3634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb2c617a7902440eb574fcb1141785ac.json"}}, {"family": "Ribeiro", "given": "Sandra Lucia Euzebio", "initials": "SLE", "orcid": "0000-0002-4777-8659", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2db6a09138844b1690855b8b44af31ec.json"}}, {"family": "Al-Emadi", "given": "Samar", "initials": "S", "orcid": "0000-0001-7942-4831", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49a627d387d042f7b99d821d9676d0d5.json"}}, {"family": "Hasseli", "given": "Rebecca", "initials": "R"}, {"family": "M\u00fcller-Ladner", "given": "Ulf", "initials": "U"}, {"family": "Specker", "given": "Christof", "initials": "C"}, {"family": "Schulze-Koops", "given": "Hendrik", "initials": "H"}, {"family": "Bernardes", "given": "Miguel", "initials": "M"}, {"family": "Machado Fraga", "given": "Vanessa", "initials": "V"}, {"family": "Rodrigues", "given": "Ana Maria", "initials": "AM"}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA", "orcid": "0000-0002-5556-4618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/192552e5e3d2435799e57111ea84502d.json"}}, {"family": "Ljung", "given": "Lotta", "initials": "L"}, {"family": "Di Giuseppe", "given": "Daniela", "initials": "D"}, {"family": "Tidblad", "given": "Liselotte", "initials": "L"}, {"family": "Wise", "given": "Leanna", "initials": "L", "orcid": "0000-0002-6172-9474", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a7e415e8715491bb9d0409d4b008443.json"}}, {"family": "Duarte-Garc\u00eda", "given": "Al\u00ed", "initials": "A", "orcid": "0000-0003-1749-5719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77a5555c1b624ba49ee7c729be2aef95.json"}}, {"family": "Ugarte-Gil", "given": "Manuel F", "initials": "MF", "orcid": "0000-0003-1728-1999", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b49a52ac208747ed9b85f286119da620.json"}}, {"family": "Colunga-Pedraza", "given": "Iris Jazm\u00edn", "initials": "IJ", "orcid": "0000-0002-2786-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50e46ef2c7f44b39a1d28fea6a8e621d.json"}}, {"family": "Mart\u00ednez-Mart\u00ednez", "given": "Marco Ulises", "initials": "MU"}, {"family": "Alpizar-Rodriguez", "given": "Deshire", "initials": "D"}, {"family": "Xavier", "given": "Ricardo Machado", "initials": "RM"}, {"family": "Isnardi", "given": "Carolina A", "initials": "CA"}, {"family": "Pera", "given": "Mariana", "initials": "M"}, {"family": "Pons-Estel", "given": "Guillermo", "initials": "G"}, {"family": "Izadi", "given": "Zara", "initials": "Z"}, {"family": "Gianfrancesco", "given": "Milena A", "initials": "MA", "orcid": "0000-0002-8351-4626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dca9cada1314065ab094be6fc17524e.json"}}, {"family": "Carrara", "given": "Greta", "initials": "G"}, {"family": "Scir\u00e8", "given": "Carlo Alberto", "initials": "CA", "orcid": "0000-0001-7451-0271", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76ebc6c1acb94b2780a38dc4e8aea708.json"}}, {"family": "Zanetti", "given": "Anna", "initials": "A"}, {"family": "Machado", "given": "Pedro M", "initials": "PM", "orcid": "0000-0002-8411-7972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef40d1eea57946e4a37d2e92a02a47cd.json"}}], "type": "journal article", "published": "2023-08-29", "journal": {"title": "Arthritis Care Res (Hoboken)", "issn": "2151-4658", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Approximately one-third of individuals worldwide have not received a COVID-19 vaccine. While studies have investigated risk factors linked to severe COVID-19 among unvaccinated people with rheumatic diseases(RD), we know less about whether these factors changed as the pandemic progressed. We aimed to identify risk factors associated with severe COVID-19 in unvaccinated individuals in different pandemic epochs corresponding to major variants of concern.\r\n\r\nPatients with RD and COVID-19 were entered into the COVID-19 Global Rheumatology Alliance registry between March 2020 and June 2022. An ordinal logistic regression model (not hospitalized, hospitalized, and death) was used with date of COVID-19 diagnosis, age, sex, race and/or ethnicity, comorbidities, RD activity, medications, and the human development index(HDI) as covariates. The main analysis included all unvaccinated patients across COVID-19 pandemic epochs; sub-analyses stratified patients according to rheumatic disease types.\r\n\r\nAmong 19,256 unvaccinated people with RD and COVID-19, those who were older, male, had more comorbidities, used glucocorticoids, had higher disease activity, or lived in lower HDI regions had worse outcomes across epochs. For those with rheumatoid arthritis, sulfasalazine and B-cell depleting therapy were associated with worse outcomes, and TNF-inhibitors were associated with improved outcomes. In those with connective tissue disease or vasculitis, B-cell depleting therapy was associated with worse outcomes.\r\n\r\nRisk factors for severe COVID-19 outcomes were similar throughout pandemic epochs in unvaccinated people with RD. Ongoing efforts, including vaccination, are needed to reduce COVID-19 severity in this population, particularly in those with medical and social vulnerabilities identified in this study. This article is protected by copyright. All rights reserved.", "doi": "10.1002/acr.25220", "pmid": "37643903", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:08:47.001Z", "modified": "2023-10-06T04:36:31.468Z"}, {"entity": "publication", "iuid": "2c3ccb5cc8be45aebd39a89e3bf7627c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c3ccb5cc8be45aebd39a89e3bf7627c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c3ccb5cc8be45aebd39a89e3bf7627c"}}, "title": "Alterations in the gut microbiome and its metabolites are associated with the immune response to mucosal immunization with Lactiplantibacillus plantarum-displaying recombinant SARS-CoV-2 spike epitopes in mice.", "authors": [{"family": "Hwang", "given": "In-Chan", "initials": "I"}, {"family": "Vasquez", "given": "Robie", "initials": "R"}, {"family": "Song", "given": "Ji Hoon", "initials": "JH"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Valeriano", "given": "Valerie Diane", "initials": "VD"}, {"family": "Kang", "given": "Dae-Kyung", "initials": "D"}], "type": "journal article", "published": "2023-08-29", "journal": {"title": "Front Cell Infect Microbiol", "issn": "2235-2988", "issn-l": null, "volume": "13", "issue": null, "pages": "1242681"}, "abstract": "Lactic acid bacteria (LAB) expressing foreign antigens have great potential as mucosal vaccines. Our previous study reported that recombinant Lactiplantibacillus plantarum SK156 displaying SARS-CoV-2 spike S1 epitopes elicited humoral and cell-mediated immune responses in mice. Here, we further examined the effect of the LAB-based mucosal vaccine on gut microbiome composition and function, and gut microbiota-derived metabolites. Forty-nine (49) female BALB/c mice were orally administered L. plantarum SK156-displaying SARS-CoV-2 spike S1 epitopes thrice (at 14-day intervals). Mucosal immunization considerably altered the gut microbiome of mice by enriching the abundance of beneficial gut bacteria, such as Muribaculaceae, Mucispirillum, Ruminococcaceae, Alistipes, Roseburia, and Clostridia vadinBB60. Moreover, the predicted function of the gut microbiome showed increased metabolic pathways for amino acids, energy, carbohydrates, cofactors, and vitamins. The fecal concentration of short-chain fatty acids, especially butyrate, was also altered by mucosal immunization. Notably, alterations in gut microbiome composition, function, and butyrate levels were positively associated with the immune response to the vaccine. Our results suggest that the gut microbiome and its metabolites may have influenced the immunogenicity of the LAB-based SARS-CoV-2 vaccine.", "doi": "10.3389/fcimb.2023.1242681", "pmid": "37705931", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10495993"}], "notes": [], "created": "2023-10-06T06:57:13.128Z", "modified": "2023-10-09T06:22:09.264Z"}, {"entity": "publication", "iuid": "acab9062e3cb4dd9b5570dcc70e685b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/acab9062e3cb4dd9b5570dcc70e685b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/acab9062e3cb4dd9b5570dcc70e685b3"}}, "title": "Quality of life of COVID-19 recovered patients: a 1-year follow-up study from Bangladesh.", "authors": [{"family": "Hawlader", "given": "Mohammad Delwer Hossain", "initials": "MDH"}, {"family": "Rashid", "given": "Md Utba", "initials": "MU"}, {"family": "Khan", "given": "Md Abdullah Saeed", "initials": "MAS"}, {"family": "Liza", "given": "Mowshomi Mannan", "initials": "MM"}, {"family": "Akter", "given": "Sharmin", "initials": "S"}, {"family": "Hossain", "given": "Mohammad Ali", "initials": "MA"}, {"family": "Rahman", "given": "Tajrin", "initials": "T"}, {"family": "Barsha", "given": "Sabrina Yesmin", "initials": "SY"}, {"family": "Shifat", "given": "Alberi Afifa", "initials": "AA"}, {"family": "Hossian", "given": "Mosharop", "initials": "M"}, {"family": "Mishu", "given": "Tahmina Zerin", "initials": "TZ"}, {"family": "Sagar", "given": "Soumik Kha", "initials": "SK"}, {"family": "Manna", "given": "Ridwana Maher", "initials": "RM"}, {"family": "Ahmed", "given": "Nawshin", "initials": "N"}, {"family": "Debu", "given": "Sree Shib Shankar Devnath", "initials": "SSSD"}, {"family": "Chowdhury", "given": "Irin", "initials": "I"}, {"family": "Sabed", "given": "Samanta", "initials": "S"}, {"family": "Ahmed", "given": "Mashrur", "initials": "M"}, {"family": "Borsha", "given": "Sabrina Afroz", "initials": "SA"}, {"family": "Al Zafar", "given": "Faraz", "initials": "F"}, {"family": "Hyder", "given": "Sabiha", "initials": "S"}, {"family": "Enam", "given": "Abdullah", "initials": "A"}, {"family": "Babul", "given": "Habiba", "initials": "H"}, {"family": "Nur", "given": "Naima", "initials": "N"}, {"family": "Haque", "given": "Miah Md Akiful", "initials": "MMA"}, {"family": "Roy", "given": "Shopnil", "initials": "S"}, {"family": "Tanvir Hassan", "given": "K M", "initials": "KM"}, {"family": "Rahman", "given": "Mohammad Lutfor", "initials": "ML"}, {"family": "Nabi", "given": "Mohammad Hayatun", "initials": "MH"}, {"family": "Dalal", "given": "Koustuv", "initials": "K", "orcid": "0000-0001-7393-796X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab5e44a17b7545988cb46cdf5b1f3e4e.json"}}], "type": "journal article", "published": "2023-08-25", "journal": {"title": "Infect Dis Poverty", "issn": "2049-9957", "issn-l": null, "volume": "12", "issue": "1", "pages": "79"}, "abstract": "The COVID-19 pandemic posed a danger to global public health because of the unprecedented physical, mental, social, and environmental impact affecting quality of life (QoL). The study aimed to find the changes in QoL among COVID-19 recovered individuals and explore the determinants of change more than 1 year after recovery in low-resource settings.\r\n\r\nCOVID-19 patients from all eight divisions of Bangladesh who were confirmed positive by reverse transcription-polymerase chain reaction from June 2020 to November 2020 and who subsequently recovered were followed up twice, once immediately after recovery and again 1 year after the first follow-up. The follow-up study was conducted from November 2021 to January 2022 among 2438 individuals using the World Health Organization Quality of Life Brief Version (WHOQOL-BREF). After excluding 48 deaths, 95 were rejected to participate, 618 were inaccessible, and there were 45 cases of incomplete data. Descriptive statistics, paired-sample analyses, generalized estimating equation (GEE) analysis, and multivariable logistic regression analyses were performed to test the mean difference in participants' QoL scores between the two interviews.\r\n\r\nMost participants (n = 1710, 70.1%) were male, and one-fourth (24.4%) were older than 46. The average physical domain score decreased significantly from baseline to follow-up, and the average scores in psychological, social, and environmental domains increased significantly at follow-up (P < 0.05). By the GEE equation approach, after adjusting for other factors, we found that older age groups (P < 0.001), being female (P < 0.001), having hospital admission during COVID-19 illness (P < 0.001), and having three or more chronic diseases (P < 0.001), were significantly associated with lower physical and psychological QoL scores. Higher age and female sex [adjusted odd ratio (aOR) = 1.3, 95% confidence interval (CI) 1.0-1.6] were associated with reduced social domain scores on multivariable logistic regression analysis. Urban or semi-urban people were 49% less likely (aOR = 0.5, 95% CI 0.4-0.7) and 32% less likely (aOR = 0.7, 95% CI 0.5-0.9) to have a reduced QoL score in the psychological domain and the social domain respectively, than rural people. Higher-income people were more likely to experience a decrease in QoL scores in physical, psychological, social, and environmental domains. Married people were 1.8 times more likely (aOR = 1.8, 95% CI 1.3-2.4) to have a decreased social QoL score. In the second interview, people admitted to hospitals during their COVID-19 infection showed a 1.3 times higher chance (aOR = 1.3, 95% CI 1.1-1.6) of a decreased environmental QoL score. Almost 13% of participants developed one or more chronic diseases between the first and second interviews. Moreover, 7.9% suffered from reinfection by COVID-19 during this 1-year time.\r\n\r\nThe present study found that the QoL of COVID-19 recovered people improved 1 year after recovery, particularly in psychological, social, and environmental domains. However, age, sex, the severity of COVID-19, smoking habits, and comorbidities were significantly negatively associated with QoL. Events of reinfection and the emergence of chronic disease were independent determinants of the decline in QoL scores in psychological, social, and physical domains, respectively. Strong policies to prevent and minimize smoking must be implemented in Bangladesh, and we must monitor and manage chronic diseases in people who have recovered from COVID-19.", "doi": "10.1186/s40249-023-01125-9", "pmid": "37626363", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10463646"}, {"db": "pii", "key": "10.1186/s40249-023-01125-9"}], "notes": [], "created": "2023-10-05T08:08:51.924Z", "modified": "2023-10-06T04:39:17.151Z"}, {"entity": "publication", "iuid": "ae50d23c447b4196954c31aa1bdc0fb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ae50d23c447b4196954c31aa1bdc0fb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ae50d23c447b4196954c31aa1bdc0fb1"}}, "title": "Bayesian monitoring of COVID-19 in Sweden.", "authors": [{"family": "Marin", "given": "Robin", "initials": "R"}, {"family": "Runvik", "given": "H\u00e5kan", "initials": "H"}, {"family": "Medvedev", "given": "Alexander", "initials": "A"}, {"family": "Engblom", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2023-08-24", "journal": {"title": "Epidemics", "issn": "1878-0067", "issn-l": null, "volume": "45", "issue": null, "pages": "100715"}, "abstract": "In an effort to provide regional decision support for the public healthcare, we design a data-driven compartment-based model of COVID-19 in Sweden. From national hospital statistics we derive parameter priors, and we develop linear filtering techniques to drive the simulations given data in the form of daily healthcare demands. We additionally propose a posterior marginal estimator which provides for an improved temporal resolution of the reproduction number estimate as well as supports robustness checks via a parametric bootstrap procedure. From our computational approach we obtain a Bayesian model of predictive value which provides important insight into the progression of the disease, including estimates of the effective reproduction number, the infection fatality rate, and the regional-level immunity. We successfully validate our posterior model against several different sources, including outputs from extensive screening programs. Since our required data in comparison is easy and non-sensitive to collect, we argue that our approach is particularly promising as a tool to support monitoring and decisions within public health. Significance: Using public data from Swedish patient registries we develop a national-scale computational model of COVID-19. The parametrized model produces valuable weekly predictions of healthcare demands at the regional level and validates well against several different sources. We also obtain critical epidemiological insights into the disease progression, including, e.g., reproduction number, immunity and disease fatality estimates. The success of the model hinges on our novel use of filtering techniques which allows us to design an accurate data-driven procedure using data exclusively from healthcare demands, i.e., our approach does not rely on public testing and is therefore very cost-effective.", "doi": "10.1016/j.epidem.2023.100715", "pmid": "37703786", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Other": null, "Funder: Vinnova": null}, "xrefs": [{"db": "pii", "key": "S1755-4365(23)00051-8"}], "notes": [], "created": "2023-10-04T12:10:33.906Z", "modified": "2023-10-06T11:35:30.320Z"}, {"entity": "publication", "iuid": "1f0f46e03164417b85380701e798b5a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1f0f46e03164417b85380701e798b5a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1f0f46e03164417b85380701e798b5a9"}}, "title": "Efficacy of Kan Jang\u00ae in Patients with Mild COVID-19: A Randomized, Quadruple-Blind, Placebo-Controlled Trial.", "authors": [{"family": "Ratiani", "given": "Levan", "initials": "L"}, {"family": "Pachkoria", "given": "Elene", "initials": "E"}, {"family": "Mamageishvili", "given": "Nato", "initials": "N"}, {"family": "Shengelia", "given": "Ramaz", "initials": "R"}, {"family": "Hovhannisyan", "given": "Areg", "initials": "A"}, {"family": "Panossian", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8467-4525", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86a40ce1842b4c289c7f09c955ad4325.json"}}], "type": "journal article", "published": "2023-08-22", "journal": {"title": "Pharmaceuticals (Basel)", "issn": "1424-8247", "issn-l": null, "volume": "16", "issue": "9", "pages": null}, "abstract": ". This study aimed to assess the efficacy of the treatment of Kan JangBackground and aim\u00ae, a fixed combination of Andrographis paniculata (Burm. F.) Wall. ex. Nees and Eleutherococcus senticosus (Rupr. & Maxim.) Maxim extracts in patients with mild symptoms of COVID-19. . One hundred and forty patients received six capsules of Kan JangMethods\u00ae (n = 68, daily dose of andrographolides-90 mg) or placebo (n = 72) and supportive treatment (paracetamol) for 14 consecutive days in a randomized, quadruple-blinded, placebo-controlled, two-parallel-group design. The efficacy outcomes were the rate of cases turning to severe, the detection rate of coronavirus SARS-CoV-2 over the time of treatment, the duration, and the severity of symptoms (sore throat, runny nose, cough, headache, fatigue, loss of smell, taste, pain in muscles) in the acute phase of the disease. Other efficacy measures included improving cognitive and physical performance, quality of life, and the levels of inflammatory blood markers-interleukin 6 (IL-6), C-reactive protein, and D-dimer. . Kan JangResults\u00ae significantly (p < 0.05) reduced the rate of cases turning to severe (5.36%) compared to the placebo (17.86%) and decreased the detection rate of SARS-CoV-2 virus over the time of the treatment. The statistical difference in the rates of patients with clinical deterioration in the Kan Jang treatment and placebo control groups was significant (p = 0.0176) both in the 112 patients in the included-per-protocol (IPP) analysis and in the 140 patients in the intended-to-treat (ITT) analysis (p = 0.0236); the absolute risk reduction in cases thanks to the Kan Jang treatment was 12.5%, and the number we needed to treat with Kan Jang was 8. The patient's recovery time (number of sick days at the home/clinic) was shorter in the Kan Jang group compared with the placebo group. The rate of attenuation of inflammatory symptoms in the Kan Jang\u00ae group was significantly higher, decreasing the severity of cough, sore throat/pain, runny nose, and muscle soreness compared with the placebo group. Kan Jang\u00ae significantly decreased the Wisconsin Upper Respiratory Symptoms scores compared to the placebo in the sample size of 140 patients. However, the relief of fatigue and headache and the decrease in IL-6 in the blood were observed only in a subset of 86 patients infected during the second three waves of the pandemic. Kan Jang\u00ae significantly increased physical activity and workout; however, it did not affect cognitive functions (attention and memory), quality of life score, inflammatory marker D-dimer, and C-reactive protein compared with the placebo group. . Overall, the results of this study suggest that Kan JangConclusions\u00ae is effective in treating mild and moderate COVID-19 irrespective of the SARS-CoV-2 variant of infection.", "doi": "10.3390/ph16091196", "pmid": "37765004", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10535596"}, {"db": "pii", "key": "ph16091196"}], "notes": [], "created": "2023-10-06T06:55:26.233Z", "modified": "2023-10-06T10:53:37.475Z"}, {"entity": "publication", "iuid": "24216cd75b2047d8a66e2d97d42d7563", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24216cd75b2047d8a66e2d97d42d7563.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24216cd75b2047d8a66e2d97d42d7563"}}, "title": "Person-centred care in nursing homes during the COVID-19 pandemic: a cross sectional study based on nursing staff and first-line managers' self-reported outcomes.", "authors": [{"family": "Lindner", "given": "Helen", "initials": "H"}, {"family": "Kihlgren", "given": "Annica", "initials": "A"}, {"family": "Pejner", "given": "Margaretha Norell", "initials": "MN"}], "type": "journal article", "published": "2023-08-21", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "issn-l": null, "volume": "22", "issue": "1", "pages": "276"}, "abstract": "COVID-19 has presented many difficulties in providing person-centred care (PCC) in nursing homes (NH). Factors such as organisational support, work condition and leadership may play a crucial role in supporting the performance of PCC during COVID restrictions. The study aim was to evaluate nursing staff and manager perceptions of the opportunities to perform person-centred care during the COVID-19 pandemic.\r\n\r\nNursing staff (NS) (n = 463) and First Line Managers (FLM) (n = 8) within all NHs in one community filled in the SVENIS questionnaire which consists of five areas: perceived organizational support, work climate, person-centred care, work conditions and leadership. A Kruskal-Wallis test was used to perform inter-group comparisons and standard multiple regression was used to investigate which factor contributed most to perform PCC.\r\n\r\nThe comparison analyses indicate that staff from nursing homes for persons with dementia had the highest opportunities to perform PCC during the pandemic. The day shift staff had more opportunities to perform PCC than night shift staff. The results from the standard multiple regression show that a NA's current nursing home was the most significant variable affecting the opportunities to perform PCC. The analyses of both the comparison analyses and the regression suggest that day shift staff from nursing homes for persons with dementia had the highest opportunities to perform PCC during the pandemic. The same group also rated the importance of leadership as high for performing PCC.\r\n\r\nDespite the COVID-19 restrictions and all the criticism directed against the care of older people; the day staff felt that they conducted PCC. Staff in nursing homes for dementia had the highest opportunities for PCC and this may be because they are better prepared to provide care for the individual in NH. The importance of leadership was also evident, which means that investment in FLMs is seen as necessary.", "doi": "10.1186/s12912-023-01437-z", "pmid": "37605177", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10440872"}, {"db": "pii", "key": "10.1186/s12912-023-01437-z"}], "notes": [], "created": "2023-10-05T08:08:54.351Z", "modified": "2023-10-06T04:40:25.696Z"}, {"entity": "publication", "iuid": "7ca4bd5cc52d4aed97bf6158b63fc396", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7ca4bd5cc52d4aed97bf6158b63fc396.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7ca4bd5cc52d4aed97bf6158b63fc396"}}, "title": "Early Onset Delirium During Hospitalization Increases In-Hospital and Postdischarge Mortality in COVID-19 Patients: A Multicenter Prospective Study.", "authors": [{"family": "Trevisan", "given": "Caterina", "initials": "C"}, {"family": "Grande", "given": "Giulia", "initials": "G"}, {"family": "Rebora", "given": "Paola", "initials": "P"}, {"family": "Zucchelli", "given": "Alberto", "initials": "A"}, {"family": "Valsecchi", "given": "Maria Grazia", "initials": "MG"}, {"family": "Foc\u00e0", "given": "Emanuele", "initials": "E"}, {"family": "Ecarnot", "given": "Fiona", "initials": "F"}, {"family": "Marengoni", "given": "Alessandra", "initials": "A"}, {"family": "Bellelli", "given": "Giuseppe", "initials": "G"}], "type": "multicenter study", "published": "2023-08-21", "journal": {"title": "J Clin Psychiatry", "issn": "1555-2101", "issn-l": null, "volume": "84", "issue": "5", "pages": null}, "abstract": "Delirium is a common feature in COVID-19 patients. Although its association with in-hospital mortality has previously been reported, data concerning postdischarge mortality and delirium subtypes are scarce. We evaluated the association between delirium and its subtypes and both in-hospital and postdischarge mortality. Objective: This multicenter longitudinal clinical-based study was conducted in Monza and Brescia, Italy. The study population included 1,324 patients (median age: 68 years) with COVID-19 admitted to 4 acute clinical wards in northern Italy during the first pandemic waves (February 2020 to January 2021). Delirium within 48 hours of hospital admission was assessed through validated scores and/or clinically according to Methods:DSM-5 criteria. The association of delirium-and its subtypes-with in-hospital and postdischarge mortality (over a median observation period of 257 [interquartile range: 189-410] days) was evaluated through Cox proportional hazards models. The 223 patients (16.8%) presenting delirium had around 2-fold increased in-hospital (hazard ratio [HR] = 1.94; 95% CI, 1.38-2.73) and postdischarge (HR = 2.01; 95% CI, 1.48-2.73) mortality than those without delirium. All delirium subtypes were associated with greater risk of death compared to the absence of delirium, but hypoactive delirium revealed the strongest associations with both in-hospital (HR = 2.03; 95% CI, 1.32-3.13) and postdischarge (HR = 2.22; 95% CI, 1.52-3.26) mortality. Results: In patients with COVID-19, early onset delirium is associated not only with in-hospital mortality but also with shorter postdischarge survival. This suggests that delirium detection and management are crucial to improving the prognosis of COVID-19 patients. Conclusions: ClinicalTrials.gov identifier: NCT04412265.Trial Registration:", "doi": "10.4088/JCP.22m14565", "pmid": "37616485", "labels": {"Category: Health": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "22m14565"}, {"db": "ClinicalTrials.gov", "key": "NCT04412265"}], "notes": [], "created": "2023-10-05T08:26:04.491Z", "modified": "2023-10-06T04:45:08.102Z"}, {"entity": "publication", "iuid": "ec5bd7a61fa74750ba0036e4f5db58e4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec5bd7a61fa74750ba0036e4f5db58e4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec5bd7a61fa74750ba0036e4f5db58e4"}}, "title": "Did the COVID-19 pandemic influence inequality in self-reported work environment conditions based on gender and place of birth? A study of a Swedish commercial laundromat.", "authors": [{"family": "Januario", "given": "Leticia Bergamin", "initials": "LB"}, {"family": "Mathiassen", "given": "Svend Erik", "initials": "SE"}, {"family": "Bergstr\u00f6m", "given": "Gunnar", "initials": "G"}, {"family": "Jackson", "given": "Jennie A", "initials": "JA"}], "type": "journal article", "published": "2023-08-21", "journal": {"title": "Appl Ergon", "issn": "1872-9126", "issn-l": null, "volume": "114", "issue": null, "pages": "104113"}, "abstract": "We evaluated differences in work environment conditions and health by gender and place of birth in a commercial laundromat prior to (baseline) and at the end of the first wave of the COVID-19 pandemic (follow-up). Using survey data, including dimensions from the Copenhagen Psychosocial Questionnaire, from forty-one workers, we assessed work environment conditions and health at baseline, follow-up and in change scores between baseline and follow-up. At baseline, men and women reported similar scores, while foreign-born (FB) workers reported better work environment conditions than Swedish-born (SB) workers. During the pandemic, conditions generally declined for all workers, but FB reported smaller declines than SB. A consistent inequality hierarchy across the 4 groups was not clear at baseline, follow-up or in change scores between time points. The study suggests potential cultural differences may exist in how work environment conditions are experienced. This should be considered in future studies and when managing future crises.", "doi": "10.1016/j.apergo.2023.104113", "pmid": "37611535", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0003-6870(23)00151-5"}], "notes": [], "created": "2023-10-05T08:26:35.912Z", "modified": "2023-10-06T05:00:50.941Z"}, {"entity": "publication", "iuid": "3aac4306641a4a01bb31154e6c7616cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3aac4306641a4a01bb31154e6c7616cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3aac4306641a4a01bb31154e6c7616cb"}}, "title": "Two cases of nursing older nursing home residents during COVID-19.", "authors": [{"family": "Jaarsma", "given": "Pier", "initials": "P", "orcid": "0000-0003-4429-2853", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91b16416951a4b2a831961d5e9a7a6d1.json"}}, {"family": "Gelhaus", "given": "Petra", "initials": "P"}, {"family": "Eklund Saksberg", "given": "My", "initials": "M"}], "type": "journal article", "published": "2023-08-19", "journal": {"title": "Nurs Ethics", "issn": "1477-0989", "issn-l": null, "volume": null, "issue": null, "pages": "9697330231185944"}, "abstract": "Two ethical challenges of nursing home nurses during the COVID-19 pandemic in Sweden are discussed in this paper.\r\n\r\nHistorically, the nurse's primary concern is for the person who is ill, which is the core of nurses' moral responsibility and identity. In Sweden, person-centered care is generally deemed important in nursing older nursing home residents.\r\n\r\nTo chart moral responsibilities of nursing home nurses in two cases involving older residents during the COVID-19 pandemic in Sweden.\r\n\r\nWe used Margaret Urban Walker's framework for moral responsibilities and the International Council of Nurses (ICN) code of ethics for nurses (2021) for our normative analysis.\r\n\r\nWritten and verbal consent was obtained before the interviews, and information was given that participation was entirely voluntary and possible to cancel at any time before the work was published. The Swedish Ethical Review Agency gave an advisory opinion stating that there were no ethical objections to this research project (Dnr. 2020-05649).\r\n\r\nCase #1: a palliative older nursing home resident who was coercively tested for COVID-19, and case #2: a COVID-19-infected resident with dementia who was isolated using sedation. The decision that was finally made in the respective case was analyzed in the light of either consequentialist/utilitarian or non-consequentialist/deontological reasons.\r\n\r\nEmpowerment of nurses as moral agents is required for the application of practical wisdom in the balancing of different care relationships (responsibilities), moral identities (professional virtues), and competing moral values. This requires resources and opens possibilities for profound ethical reflection in nursing education and at work.\r\n\r\nDuring the COVID-19 pandemic, the moral and professional responsibility of nursing home nurses to deliver person-centered care was sometimes problematically abandoned in favor of a more utilitarian manner of ethical decision-making.", "doi": "10.1177/09697330231185944", "pmid": "37597000", "labels": {"Funder: Forte": null, "Type: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:08:37.400Z", "modified": "2023-10-05T08:55:22.474Z"}, {"entity": "publication", "iuid": "4ed3677531104d9392850a68bffd903f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ed3677531104d9392850a68bffd903f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ed3677531104d9392850a68bffd903f"}}, "title": "Risk and outcomes of COVID-19 in patients with oxygen-dependent chronic respiratory failure- a national cohort study.", "authors": [{"family": "Sundh", "given": "Josefin", "initials": "J"}, {"family": "Palm", "given": "Andreas", "initials": "A"}, {"family": "Ljunggren", "given": "Mirjam", "initials": "M"}, {"family": "Emilsson", "given": "\u00d6ssur Ingi", "initials": "\u00d6I"}, {"family": "Grote", "given": "Ludger", "initials": "L"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ekstr\u00f6m", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2023-08-19", "journal": {"title": "Respir Med", "issn": "1532-3064", "issn-l": "0954-6111", "volume": "218", "issue": null, "pages": "107392"}, "abstract": "We aimed to evaluate cumulative occurrence and impact of COVID-19 in patients with chronic respiratory failure (CRF) treated with long-term oxygen therapy (LTOT).\r\n\r\nData were obtained from the SCIFI-PEARL study on the entire Swedish population and on patients with oxygen-dependent CRF and no COVID-19 diagnosis before start of LTOT. Analyses were performed for three time periods; pre-alpha (Jan-Dec 2020), alpha (Jan-Mar 2021) and delta/omicron (Apr 2021-May 2022). Cumulative incidence of laboratory-verified COVID-19 was compared between patients with CRF and the general population. Risk factors for severe (hospitalised) to critical (intensive care, or death \u226430 days after infection) COVID-19, and the impact of COVID-19 on one-year mortality, were analysed using multivariable Cox regression.\r\n\r\nCumulative incidence of COVID-19 was higher in patients with CRF than in the general population during the pre-alpha period (6.4%/4.9%, p = 0.002), but less common during the alpha and delta/omicron periods (2.9%/3.8% and 7.8%/15.5%, p < 0.0001 for both). The risk of severe/critical COVID-19 was much higher in CRF patients during all periods (4.9%/0.5%, 3.8%/0.2% and 15.5%/0.5%, p < 0.0001 for all). Risk factors for COVID-19 infection in people with CRF were higher age, cardiovascular and renal disease, and COVID-19 was associated with increased one-year mortality following infection in the pre-alpha (HR 1.79; [95% CI] 1.27-2.53) and alpha periods (1.43; 1.03-1.99).\r\n\r\nPatients with CRF had higher risk of severe/critical COVID-19 than the general population. COVID-19 infection was associated with excess one-year mortality.", "doi": "10.1016/j.rmed.2023.107392", "pmid": "37598894", "labels": {"Category: Health": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pii", "key": "S0954-6111(23)00280-9"}], "notes": [], "created": "2023-10-05T08:02:26.196Z", "modified": "2023-10-05T08:42:32.803Z"}, {"entity": "publication", "iuid": "3e633c6a7f7043679e7d6028c9f85f40", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3e633c6a7f7043679e7d6028c9f85f40.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3e633c6a7f7043679e7d6028c9f85f40"}}, "title": "Variations across Europe in hospitalization and management of pregnant women with SARS-CoV-2 during the initial phase of the pandemic: Multi-national population-based cohort study using the International Network of Obstetric Survey Systems (INOSS).", "authors": [{"family": "de Bruin", "given": "Odette", "initials": "O", "orcid": "0000-0001-6295-3411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cb1846613dd40b0a620d3b57bdf7012.json"}}, {"family": "Engjom", "given": "Hilde", "initials": "H", "orcid": "0000-0003-1582-4283", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c252a103177f4a12a560a5fa1a02941a.json"}}, {"family": "Vousden", "given": "Nicola", "initials": "N"}, {"family": "Ramakrishnan", "given": "Rema", "initials": "R"}, {"family": "Aabakke", "given": "Anna J M", "initials": "AJM", "orcid": "0000-0003-4754-506X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c142bd2b1fc84a7e864d2af58096bcaf.json"}}, {"family": "\u00c4yr\u00e4s", "given": "Outi", "initials": "O", "orcid": "0000-0002-2423-611X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45245d469a6a4629bb3197f51be274bf.json"}}, {"family": "Donati", "given": "Serena", "initials": "S", "orcid": "0000-0002-4607-2072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52c96021dc5f4d41a7098cd3b5815649.json"}}, {"family": "J\u00f3nasd\u00f3ttir", "given": "Eva", "initials": "E"}, {"family": "Knight", "given": "Marian", "initials": "M", "orcid": "0000-0002-1984-4575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c2039d5a7904bb2b86fcc9288b1c4fa.json"}}, {"family": "Overtoom", "given": "Evelien M", "initials": "EM", "orcid": "0000-0001-6454-4531", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd001d702fe0494ebe68a0d0b4dae739.json"}}, {"family": "Salvatore", "given": "Michele A", "initials": "MA"}, {"family": "Sturkenboom", "given": "Miriam C J M", "initials": "MCJM"}, {"family": "Svanvik", "given": "Teresia", "initials": "T", "orcid": "0000-0003-1947-679X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5c912ccb32524c468a81dd35f17f10cb.json"}}, {"family": "Varpula", "given": "Reetta", "initials": "R"}, {"family": "Vercoutere", "given": "An", "initials": "A"}, {"family": "Bloemenkamp", "given": "Kitty W M", "initials": "KWM", "orcid": "0000-0002-1377-4625", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6fc16703b53043369e998576c3e74737.json"}}, {"family": "INOSS COVID-19 Working Group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-08-18", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "issn-l": "0001-6349", "volume": null, "issue": null, "pages": null}, "abstract": "The majority of data on COVID-19 in pregnancy are not from sound population-based active surveillance systems.\r\n\r\nWe conducted a multi-national study of population-based national or regional prospective cohorts using standardized definitions within the International Network of Obstetric Survey systems (INOSS). From a source population of women giving birth between March 1 and August 31, 2020, we included pregnant women admitted to hospital with a positive SARS-CoV-2 PCR test \u22647 days prior to or during admission and up to 2 days after birth. The admissions were further categorized as COVID-19-related or non-COVID-19-related. The primary outcome of interest was incidence of COVID-19-related hospital admission. Secondary outcomes included severe maternal disease (ICU admission and mechanical ventilation) and COVID-19-directed medical treatment.\r\n\r\nIn a source population of 816 628 maternities, a total of 2338 pregnant women were admitted with SARS-CoV-2; among them 940 (40%) were COVID-19-related admissions. The pooled incidence estimate for COVID-19-related admission was 0.59 (95% confidence interval 0.27-1.02) per 1000 maternities, with notable heterogeneity across countries (I2 = 97.3%, P = 0.00). In the COVID-19 admission group, between 8% and 17% of the women were admitted to intensive care, and 5%-13% needed mechanical ventilation. Thromboprophylaxis was the most frequent treatment given during COVID-19-related admission (range 14%-55%). Among 908 infants born to women in the COVID-19-related admission group, 5 (0.6%) stillbirths were reported.\r\n\r\nDuring the initial months of the pandemic, we found substantial variations in incidence of COVID-19-related admissions in nine European countries. Few pregnant women received COVID-19-directed medical treatment. Several barriers to rapid surveillance were identified. Investment in robust surveillance should be prioritized to prepare for future pandemics.", "doi": "10.1111/aogs.14643", "pmid": "37594175", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:01:41.758Z", "modified": "2023-10-05T08:31:24.775Z"}, {"entity": "publication", "iuid": "fd298155e85d4de1bf6e8e9532a22e63", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fd298155e85d4de1bf6e8e9532a22e63.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fd298155e85d4de1bf6e8e9532a22e63"}}, "title": "Hospital Admission Rates in Patients with COPD Throughout the COVID-19 Pandemic.", "authors": [{"family": "Andreen", "given": "Niklas", "initials": "N", "orcid": "0000-0002-7349-3120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/112f52ac7eb84986ba16b220903beb5f.json"}}, {"family": "Westin", "given": "Johan", "initials": "J"}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW", "orcid": "0000-0002-4387-4096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bb5d1f761ef48c4837ed4f984717f0e.json"}}], "type": "journal article", "published": "2023-08-17", "journal": {"title": "Int J Chron Obstruct Pulmon Dis", "issn": "1178-2005", "issn-l": null, "volume": "18", "issue": null, "pages": "1763-1772"}, "abstract": "Several studies report decreased hospital admissions for acute exacerbations of COPD (AECOPD) during the COVID-19 pandemic. However, there are no studies that compare AECOPD admissions with admissions for respiratory infections, including COVID-19. This study aimed to examine hospital admission rates for AECOPD, pneumonia, influenza, and COVID-19 among COPD patients, before and during the COVID-19 pandemic.\r\n\r\nWe obtained anonymized data on hospital admissions of patients with COPD and a primary diagnosis code for AECOPD, pneumonia, influenza, or COVID-19, from the hospital patient admission register at a large Swedish hospital. The study compared the pandemic period (February 2020-March 2022) to a period before the pandemic (June 2017-January 2020). Sequential phases of the pandemic were evaluated separately. Monthly admission rates were compared using Poisson regression, controlling for admission month.\r\n\r\nComparing monthly admission rates during the pandemic with the prepandemic period, incidence rate ratios were 0.72 for AECOPD (95% CI 0.67-0.77; p<0.001), 0.56 for pneumonia (95% CI 0.49-0.62; p<0.001), 0.18 for influenza during the winter period (95% CI 0.10-0.30; p<0.001) and 0.79 for total COPD admissions, including COVID-19 (95% CI 0.75-0.84; p<0.001). The study showed significantly lower rate ratios for AECOPD, pneumonia, and total COPD admissions during the first, second, third, and fifth (Omicron) waves. No significant effect on admissions was seen after the withdrawal of restriction measures.\r\n\r\nThere was a significant reduction in the overall rate of hospital admissions among COPD patients for AECOPD, pneumonia, and respiratory viral infections during the pandemic despite the rise in COVID-19 admissions. However, prepandemic admission levels returned in the post-restriction period.", "doi": "10.2147/COPD.S409452", "pmid": "37608833", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC10441640"}, {"db": "pii", "key": "409452"}], "notes": [], "created": "2023-10-05T08:02:43.676Z", "modified": "2023-10-05T08:51:00.004Z"}, {"entity": "publication", "iuid": "b8666e1363444f6787a65e606a5a9b78", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8666e1363444f6787a65e606a5a9b78.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8666e1363444f6787a65e606a5a9b78"}}, "title": "Pandemic stressors and mental health indicators in eight countries.", "authors": [{"family": "Abdalla", "given": "Salma M", "initials": "SM"}, {"family": "Koya", "given": "Shaffi Fazaludeen", "initials": "SF"}, {"family": "Rosenberg", "given": "Samuel B", "initials": "SB"}, {"family": "Stovall", "given": "Isaac B", "initials": "IB"}, {"family": "Biermann", "given": "Olivia", "initials": "O"}, {"family": "Zeinali", "given": "Zahra", "initials": "Z"}, {"family": "Cohen", "given": "Gregory H", "initials": "GH"}, {"family": "Ettman", "given": "Catherine K", "initials": "CK"}, {"family": "Galea", "given": "Sandro", "initials": "S"}], "type": "journal article", "published": "2023-08-16", "journal": {"title": "Soc Psychiatry Psychiatr Epidemiol", "issn": "1433-9285", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The Covid-19 pandemic has exacted a significant physical, financial, social, and emotional toll on populations throughout the world. This study aimed to document the association between pandemic stressors and mental health during the pandemic across countries that differ in cultural, geographic, economic, and demographic factors.\r\n\r\nWe administered an online survey randomly in Brazil, China, Germany, Egypt, India, Indonesia, Nigeria, and the United States from September 2020 to November 2020. This survey included questions on Covid-19-related stressors as well as the Patient Health Questionnaire-2 and the Primary Care PTSD Checklist to screen for depression and post-traumatic stress disorder (PTSD) symptoms, respectively. We performed bivariable and multivariable regression analyses to assess the prevalence and odds ratios of overall depression symptoms and probable PTSD and in relation to stressors across countries.\r\n\r\nAmong 8754 respondents, 28.9% (95% CI 27.5-30.0%) experienced depression symptoms, and 5.1% (95% CI 4.5-6.0%) experienced probable PTSD. The highest prevalence of depression symptoms was in Egypt (41.3%, 95% CI 37.6-45.0%) and lowest in the United States (24.9%, 95% CI 22.3-27.7%). The highest prevalence of probable PTSD was in Brazil (7.3%, 95% CI 5.6-9.4%) and the lowest in China (1.2%, 95% CI 0.7-2.0%). Overall, experiencing six or more Covid-19-related stressors was associated with both depression symptoms (OR 1.90, 95% CI 1.46-2.48) and probable PTSD (OR 13.8, 95% CI 9.66-19.6).\r\n\r\nThe association between pandemic related stressors and the burden of adverse mental health indicators early in the Covid-19 pandemic transcended geographic, economic, cultural, and demographic differences between countries. The short-term and long-term impacts of the pandemic on mental health should be incorporated in efforts to tackle the consequences of Covid-19.", "doi": "10.1007/s00127-023-02541-w", "pmid": "37587229", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00127-023-02541-w"}], "notes": [], "created": "2023-10-05T08:08:56.769Z", "modified": "2023-10-06T04:41:31.399Z"}, {"entity": "publication", "iuid": "3a7396ea5aa8414ab1dbf4c1cb3eb871", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a7396ea5aa8414ab1dbf4c1cb3eb871.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a7396ea5aa8414ab1dbf4c1cb3eb871"}}, "title": "COVID-19 Restrictions Resulted in Both Positive and Negative Effects on Digital Media Use, Mental Health, and Lifestyle Habits.", "authors": [{"family": "Nutley", "given": "Sissela B", "initials": "SB", "orcid": "0000-0002-0676-0380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76343d4da98a4fa0b45ae8cd79ceb6ae.json"}}, {"family": "Bur\u00e9n", "given": "Jonas", "initials": "J"}, {"family": "Thorell", "given": "Lisa B", "initials": "LB", "orcid": "0000-0002-7417-6637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c947bd794d04fd492bca68071260ed5.json"}}], "type": "journal article", "published": "2023-08-16", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "20", "issue": "16", "pages": null}, "abstract": "While studies have reported effects on digital media during the COVID-19 restrictions, few have included data prior to the pandemic, and most have only measured screen time. We therefore investigated changes in specific digital media activities, as well as mental health and lifestyle habits, in a longitudinal study of adolescents spanning from before the pandemic (T1) to one month into restrictions (T2) and one year later when schools had reopened (T3). Adolescents (16-19 years) rated smartphone use, problematic/addictive media use, negative experiences (e.g., victimization), mental health (i.e., irritability, stress, and closeness), and protective lifestyle habits (i.e., sleep and exercise). Results showed initial decreases in irritability and negative digital experiences, increases in sleep and exercise, as well as a decrease in closeness during remote learning (T2). However, these changes returned to, or superseded, their initial levels at follow-up (T3). There were also increases in digital media use and stress at T3. Conclusively, by investigating specific digital media activities and collecting data both prior to and during different phases of the pandemic, we were able to find both positive and negative effects.", "doi": "10.3390/ijerph20166583", "pmid": "37623169", "labels": {"Type: Journal article": null, "Funder: Forte": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10454500"}, {"db": "pii", "key": "ijerph20166583"}], "notes": [], "created": "2023-10-05T08:26:48.574Z", "modified": "2023-10-06T05:06:46.288Z"}, {"entity": "publication", "iuid": "47f7b9fd9c1f4e7a85351dc2de766f48", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47f7b9fd9c1f4e7a85351dc2de766f48.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47f7b9fd9c1f4e7a85351dc2de766f48"}}, "title": "Nursing Students' Computer Anxiety and Attitudes Before and During the COVID-19 Pandemic.", "authors": [{"family": "Papathanasiou", "given": "Ioanna V", "initials": "IV"}, {"family": "Mantzaris", "given": "Dimitrios", "initials": "D"}, {"family": "Fradelos", "given": "Evangelos C", "initials": "EC"}, {"family": "Christodoulou", "given": "Nikolaos G", "initials": "NG"}, {"family": "Lee", "given": "Ka Yiu", "initials": "KY"}, {"family": "Tsaloglidou", "given": "Areti", "initials": "A"}, {"family": "Albani", "given": "Eleni", "initials": "E"}, {"family": "Malli", "given": "Foteini", "initials": "F"}, {"family": "Gourgoulianis", "given": "Konstantinos I", "initials": "KI"}], "type": "journal article", "published": "2023-08-15", "journal": {"title": "Adv Exp Med Biol", "issn": "0065-2598", "issn-l": null, "volume": "1425", "issue": null, "pages": "377-391"}, "abstract": "Purpose of this research was to investigate how the COVID-19 pandemic affected the level of computer anxiety of nursing students and also their attitude related to computer use. A cross-sectional study was conducted in two periods, one before the COVID-19 pandemic (1st period) and the second during the COVID-19 pandemic (2nd period). The research instrument consisted of three parts, a questionnaire with questions about demographic and educational characteristics such as gender and semester of study, the Computer Anxiety Rating Scale (CARS), that used to assess the nursing students' levels of computer anxiety and the Computer Attitude Scale (CAS) that used to measure nursing students' positive and negative attitudes towards computers. Data from 957 undergraduate nursing students were obtained. Specifically, in the 1st period, 370 nursing students participated (38.66%), while in the 2nd period 587 (61.34%) undergraduates participated. The anxiety of participants during COVID-19 pandemic period was reduced compared to that of participants before the COVID-19 period. Respondents during the COVID-19 pandemic have fewer negative feelings towards computers, based on their answers in contrast to the participants in the study before the COVID-19 pandemic. Computer anxiety and attitudes have change among nursing students among COVID-19 pandemic. Nursing students after the implementation of online training are reporting positive feeling towards computer use and are more confident for their ICT skills.", "doi": "10.1007/978-3-031-31986-0_37", "pmid": "37581812", "labels": {"Type: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:26:12.089Z", "modified": "2023-10-06T04:49:37.366Z"}, {"entity": "publication", "iuid": "eb4c2d66486d424195bec82ba310b6ab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb4c2d66486d424195bec82ba310b6ab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb4c2d66486d424195bec82ba310b6ab"}}, "title": "Inequalities in COVID-19 severe morbidity and mortality by country of birth in Sweden.", "authors": [{"family": "Rostila", "given": "Mikael", "initials": "M", "orcid": "0000-0002-6973-0381", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42aa27e8e952465daa11c765ad564808.json"}}, {"family": "Cederstr\u00f6m", "given": "Agneta", "initials": "A"}, {"family": "Wallace", "given": "Matthew", "initials": "M", "orcid": "0000-0002-8318-7952", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e784144db22491f98c4a7ced1fdfab7.json"}}, {"family": "Aradhya", "given": "Siddartha", "initials": "S", "orcid": "0000-0003-3748-6270", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07f9e1a0528249a7ba6d39e2c0f3a7fe.json"}}, {"family": "Ahrne", "given": "Malin", "initials": "M"}, {"family": "Ju\u00e1rez", "given": "Sol P", "initials": "SP"}], "type": "journal article", "published": "2023-08-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "14", "issue": "1", "pages": "4919"}, "abstract": "Migrants have been more affected by the COVID-19 pandemic. Whether this has varied over the course of the pandemic remains unknown. We examined how inequalities in intensive care unit (ICU) admission and death related to COVID-19 by country of birth have evolved over the course of the pandemic, while considering the contribution of social conditions and vaccination uptake. A population-based cohort study was conducted including adults living in Sweden between March 1, 2020 and June 1, 2022 (n = 7,870,441). Poisson regressions found that migrants from Africa, Middle East, Asia and European countries without EU28/EEA, UK and Switzerland had higher risk of COVID-19 mortality and ICU admission than Swedish-born. High risks of COVID-19 ICU admission was also found in migrants from South America. Inequalities were generally reduced through subsequent waves of the pandemic. In many migrant groups socioeconomic status and living conditions contributed to the disparities while vaccination campaigns were decisive when such became available.", "doi": "10.1038/s41467-023-40568-4", "pmid": "37582909", "labels": {"Type: Journal article": null, "Funder: Forte": null, "Category: Public Health": null, "Category: Social Science & Humanities": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC10427621"}, {"db": "pii", "key": "10.1038/s41467-023-40568-4"}], "notes": [], "created": "2023-10-05T08:02:36.268Z", "modified": "2023-10-05T08:47:35.755Z"}, {"entity": "publication", "iuid": "380828967d5742d18e08ee66be00f624", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/380828967d5742d18e08ee66be00f624.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/380828967d5742d18e08ee66be00f624"}}, "title": "Influence of experience, tenure, and organisational preparedness on nurses' readiness in responding to disasters: An exploration during the COVID-19 pandemic.", "authors": [{"family": "Goniewicz", "given": "Mariusz", "initials": "M"}, {"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}, {"family": "W\u0142oszczak-Szubzda", "given": "Anna", "initials": "A"}, {"family": "Lasota", "given": "Dorota", "initials": "D"}, {"family": "Al-Wathinani", "given": "Ahmed M", "initials": "AM"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}], "type": "journal article", "published": "2023-08-14", "journal": {"title": "J Glob Health", "issn": "2047-2986", "issn-l": "2047-2978", "volume": "13", "issue": null, "pages": "06034"}, "abstract": "The coronavirus 2019 (COVID-19) pandemic has placed unprecedented challenges on the nursing practice, particularly in Poland. Nurses, as crucial healthcare service providers, have faced organisational disruptions, altered working conditions, and heightened professional anxieties.\r\n\r\nWe undertook a comprehensive survey across all medical centres in Lublin, Poland in 2020 to understand nurses' attitudes towards their roles and working conditions during the pandemic. This involved 470 nurses completing a questionnaire which focused on four pivotal areas: readiness to be on call in a disaster situation (even when not formally asked); willingness to work overtime in a disaster without additional compensation, preparedness to undertake health risks by caring for individuals with infectious diseases or exposure to hazardous substances, and willingness to be transferred to other departments during a disaster.\r\n\r\nWe found that excessive workload, fear of infection, and feelings of helplessness significantly influenced nurses' readiness to work overtime, particularly when unpaid. We also presented the ethical dilemmas that nurses encountered during the pandemic and how these dilemmas affected their decision-making processes. We further explored the impact of variables such as nurses' professional experience, tenure, and level of organisational preparedness on their readiness to respond to crisis situations.\r\n\r\nGaining an understanding of nurses' perspectives is key for formulating strategies to bolster their professional engagements and resilience during crises. Addressing these issues can help build a more robust and well-prepared healthcare system that can effectively navigate future crises.", "doi": "10.7189/jogh.13.06034", "pmid": "37572372", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10423066"}], "notes": [], "created": "2023-10-05T08:26:54.564Z", "modified": "2023-10-06T05:17:33.511Z"}, {"entity": "publication", "iuid": "5f742fa06f844a49b6242edfc3f1de15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f742fa06f844a49b6242edfc3f1de15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f742fa06f844a49b6242edfc3f1de15"}}, "title": "Waning protection after vaccination and prior infection against COVID-19-related mortality over 18 months.", "authors": [{"family": "Dietler", "given": "Dominik", "initials": "D"}, {"family": "Kahn", "given": "Fredrik", "initials": "F"}, {"family": "Inghammar", "given": "Malin", "initials": "M"}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2023-08-12", "journal": {"title": "Clin Microbiol Infect", "issn": "1469-0691", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Evidence on waning patterns in protection from vaccine-induced, infection-induced, and hybrid immunity against death is scarce. The aim of this study is to assess the temporal trends in protection against mortality.\r\n\r\nPopulation-based case-control study nested in the total population of Scania Region, Sweden using individual-level registry data of COVID-19-related deaths (<30 days after positive SARS-CoV-2 test) between 27 December 2020 and 3 June 2022. Controls were matched for age, sex, and index date. Conditional logistic regression was used to estimate the preventable fraction (PF) from vaccination (PFvac corresponding to vaccine effectiveness; \u22652 vaccine doses vs. 0 doses), prior infection (PFinf), and hybrid immunity (PFhybrid). PF was calculated as one minus odds ratio. Models were adjusted for comorbidities, long-term care facility residence, prior infection (for PFvac), country of birth, socio-economic conditions, and time since last vaccination (for PFinf).\r\n\r\nIn total, 14 936 individuals (1440 COVID-19-related deaths and 13 496 controls) were included in the case-control analyses (45% females, median age: 84 years). PFvac was above 90% during the first month after vaccination, regardless of the number of vaccine doses. After 6 months, PFvac of two doses waned to 34% (95% CI: -30% to 66%). PFinf for people surviving a SARS-CoV-2 infection waned from 88% (-16% to 99%) 3 months after infection to 62% (34-79%) after 9 months. No differences in waning patterns in PFvac were seen between virus variants, gender, and age.\r\n\r\nGiven the waning of protection against death, continuous surveillance of population immunity status, particularly among the most vulnerable population groups, could help to further fine-tune vaccination recommendations.", "doi": "10.1016/j.cmi.2023.08.007", "pmid": "37580016", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Public Health": null, "Funder: Vinnova": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(23)00388-9"}], "notes": [], "created": "2023-10-05T08:02:23.898Z", "modified": "2023-10-05T08:41:21.267Z"}, {"entity": "publication", "iuid": "8525adc10add43ec92a8865a509bd63b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8525adc10add43ec92a8865a509bd63b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8525adc10add43ec92a8865a509bd63b"}}, "title": "Central nervous system biomarkers GFAp and NfL associate with post-acute cognitive impairment and fatigue following critical COVID-19.", "authors": [{"family": "Bark", "given": "Lovisa", "initials": "L"}, {"family": "Larsson", "given": "Ing-Marie", "initials": "I"}, {"family": "Wallin", "given": "Ewa", "initials": "E"}, {"family": "Simr\u00e9n", "given": "Joel", "initials": "J"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2023-08-12", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "13144"}, "abstract": "A high proportion of patients with coronavirus disease 2019 (COVID-19) experience post-acute COVID-19, including neuropsychiatric symptoms. Objective signs of central nervous system (CNS) damage can be investigated using CNS biomarkers such as glial fibrillary acidic protein (GFAp), neurofilament light chain (NfL) and total tau (t-tau). We have examined whether CNS biomarkers can predict fatigue and cognitive impairment 3-6 months after discharge from the intensive care unit (ICU) in critically ill COVID-19 patients. Fifty-seven COVID-19 patients admitted to the ICU were included with analysis of CNS biomarkers in blood at the ICU and at follow up. Cognitive dysfunction and fatigue were assessed with the Montreal Cognitive Assessment (MoCA) and the Multidimensional Fatigue inventory (MFI-20). Elevated GFAp at follow-up 3-6 months after ICU discharge was associated to the development of mild cognitive dysfunction (p = 0.01), especially in women (p = 0.005). Patients who experienced different dimensions of fatigue at follow-up had significantly lower GFAp in both the ICU and at follow-up, specifically in general fatigue (p = 0.009), physical fatigue (p = 0.004), mental fatigue (p = 0.001), and reduced motivation (p = 0.001). Women showed a more pronounced decrease in GFAp compared to men, except for in mental fatigue where men showed a more pronounced GFAp decrease compared to women. NfL concentration at follow-up was lower in patients who experienced reduced motivation (p = 0.004). Our findings suggest that GFAp and NfL are associated with neuropsychiatric outcome after critical COVID-19.Trial registration The study was registered \u00e0 priori (clinicaltrials.gov: NCT04316884 registered on 2020-03-13 and NCT04474249 registered on 2020-06-29).", "doi": "10.1038/s41598-023-39698-y", "pmid": "37573366", "labels": {"Funder: VR": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: KAW/SciLifeLab": null, "Category: Post-COVID": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10423244"}, {"db": "pii", "key": "10.1038/s41598-023-39698-y"}, {"db": "ClinicalTrials.gov", "key": "NCT04316884"}, {"db": "ClinicalTrials.gov", "key": "NCT04474249"}], "notes": [], "created": "2023-10-05T08:02:46.150Z", "modified": "2023-10-05T08:52:57.648Z"}, {"entity": "publication", "iuid": "19645b528efb4222a1fa99f67fcfa83f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19645b528efb4222a1fa99f67fcfa83f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19645b528efb4222a1fa99f67fcfa83f"}}, "title": "Transparency in Infectious Disease Research: Meta-research Survey of Specialty Journals.", "authors": [{"family": "Zavalis", "given": "Emmanuel A", "initials": "EA"}, {"family": "Contopoulos-Ioannidis", "given": "Despina G", "initials": "DG"}, {"family": "Ioannidis", "given": "John P A", "initials": "JPA"}], "type": "journal article", "published": "2023-08-11", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899", "volume": "228", "issue": "3", "pages": "227-234"}, "abstract": "Infectious diseases carry large global burdens and have implications for society at large. Therefore, reproducible, transparent research is extremely important.\r\n\r\nWe evaluated transparency indicators (code and data sharing, registration, and conflict and funding disclosures) in the 5340 PubMed Central Open Access articles published in 2019 or 2021 in the 9 most cited specialty journals in infectious diseases using the text-mining R package, rtransparent.\r\n\r\nA total of 5340 articles were evaluated (1860 published in 2019 and 3480 in 2021 [of which 1828 were on coronavirus disease 2019, or COVID-19]). Text mining identified code sharing in 98 (2%) articles, data sharing in 498 (9%), registration in 446 (8%), conflict of interest disclosures in 4209 (79%), and funding disclosures in 4866 (91%). There were substantial differences across the 9 journals: 1%-9% for code sharing, 5%-25% for data sharing, 1%-31% for registration, 7%-100% for conflicts of interest, and 65%-100% for funding disclosures. Validation-corrected imputed estimates were 3%, 11%, 8%, 79%, and 92%, respectively. There were no major differences between articles published in 2019 and non-COVID-19 articles in 2021. In 2021, non-COVID-19 articles had more data sharing (12%) than COVID-19 articles (4%).\r\n\r\nData sharing, code sharing, and registration are very uncommon in infectious disease specialty journals. Increased transparency is required.", "doi": "10.1093/infdis/jiad130", "pmid": "37132475", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7150367"}], "notes": [], "created": "2023-10-04T05:09:56.676Z", "modified": "2023-10-04T06:24:40.130Z"}, {"entity": "publication", "iuid": "7a9030d1303f42c58b565c64d9aa8399", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a9030d1303f42c58b565c64d9aa8399.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a9030d1303f42c58b565c64d9aa8399"}}, "title": "Real-World Utilization of Molnupiravir during the COVID-19 Omicron Surge in Israel.", "authors": [{"family": "Weil", "given": "Clara", "initials": "C", "orcid": "0000-0002-0174-7208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7720ae3cd164504b6b6cb631a334704.json"}}, {"family": "Bergroth", "given": "Tobias", "initials": "T"}, {"family": "Eisenberg", "given": "Anna", "initials": "A", "orcid": "0000-0003-4292-0967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/983fc62ecb3544619b5430598e7a50c9.json"}}, {"family": "Whiteside", "given": "Yohance Omar", "initials": "YO", "orcid": "0000-0002-7828-3018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce7b53acac3441df9dc098073b66b995.json"}}, {"family": "Caraco", "given": "Yoseph", "initials": "Y"}, {"family": "Tene", "given": "Lilac", "initials": "L"}, {"family": "Chodick", "given": "Gabriel", "initials": "G", "orcid": "0000-0002-5189-8995", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed9fe6a3219549849c751198e9c47e1c.json"}}], "type": "journal article", "published": "2023-08-10", "journal": {"title": "Epidemiologia (Basel)", "issn": "2673-3986", "issn-l": null, "volume": "4", "issue": "3", "pages": "309-321"}, "abstract": "Molnupiravir (MOV) was introduced in Israel in January 2022 during the SARS-CoV-2 Omicron surge for high-risk patients contraindicated for nirmatrelvir/ritonavir. This retrospective cohort study aimed to describe characteristics of patients offered COVID-19 antiviral treatment in Maccabi Healthcare Services (antiviral treatment-eligible cohort; n = 5596) between 12 January and 28 February 2022, and the subset of these who were dispensed MOV (MOV-treated cohort; n = 1147), as well as outcomes following MOV dispensation. Median (interquartile range) age in the antiviral treatment-eligible and MOV-treated cohorts were 70.5 (61.1, 77.3) and 74.1 (64.3, 81.7) years, respectively. The MOV-treated cohort (male: 53.2%) had high rates of COVID-19 vaccination (91.4%) and comorbidities, including immunosuppression (40.0%) and chronic kidney disease (67.0%; eGFR < 30 mL/min/1.73 m2: 28.8%), and most used comedications either contraindicated or with major potential for drug-drug interactions with nirmatrelvir/ritonavir (87.3%). At 28 days post-MOV dispensation, the cumulative incidence (95% CI) of COVID-19-related hospitalization and/or all-cause mortality was 3.6% (2.5%, 4.6%), with similar rates across sexes and age groups (18-64 vs. \u226565 years), and lower rates among recently vaccinated and/or recently SARS-CoV-2-infected patients. These data describe the characteristics and outcomes for MOV-treated patients in Israel, whose clinical characteristics may preclude the use of nirmatrelvir/ritonavir to treat their COVID-19 infection.", "doi": "10.3390/epidemiologia4030031", "pmid": "37606468", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10443270"}, {"db": "pii", "key": "epidemiologia4030031"}], "notes": [], "created": "2023-10-05T08:01:45.632Z", "modified": "2023-10-05T08:34:09.246Z"}, {"entity": "publication", "iuid": "170e5853d8cc408d975bf1beb2797485", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/170e5853d8cc408d975bf1beb2797485.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/170e5853d8cc408d975bf1beb2797485"}}, "title": "Asthma in the era of COVID-19.", "authors": [{"family": "Assaf", "given": "Sara", "initials": "S"}, {"family": "Stenberg", "given": "Henning", "initials": "H"}, {"family": "Jesenak", "given": "Milos", "initials": "M"}, {"family": "Tarasevych", "given": "Svitlana P", "initials": "SP"}, {"family": "Hanania", "given": "Nicola A", "initials": "NA"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}], "type": "journal article", "published": "2023-08-10", "journal": {"title": "Respir Med", "issn": "1532-3064", "issn-l": "0954-6111", "volume": "218", "issue": null, "pages": "107373"}, "abstract": "Since its global invasion in 2019, COVID-19 has affected several aspects of patients' lives and posed a significant impact on the health care system. Several patient populations were identified to be at high risk of contracting SARS-CoV-2 infection and/or developing severe COVID-19-related sequelae. Conversely, anyone who has contracted SARS-CoV-2 is at risk to experience symptoms and signs consistent with post-COVID manifestations. Patients with asthma were initially thought to be at increased risk and severity for SARS-CoV-2 infection. However, accumulating evidence demonstrates that asthma endotypes/phenotypes and comorbidities influence the risk stratification in this population. Furthermore, initial concerns about the potentially increased risk of poor outcomes with asthma treatments such as inhaled corticosteroids and biologics have not been substantiated. In this review, we provide an update on COVID-19 and asthma, including risk of susceptibility, clinical manifestations and course in this population as well as discuss recommendations for management.", "doi": "10.1016/j.rmed.2023.107373", "pmid": "37567514", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0954-6111(23)00261-5"}], "notes": [], "created": "2023-10-05T08:01:36.893Z", "modified": "2023-10-05T08:29:04.018Z"}, {"entity": "publication", "iuid": "a387f635b5584204bd765f1418785203", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a387f635b5584204bd765f1418785203.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a387f635b5584204bd765f1418785203"}}, "title": "Effects of the COVID-19 pandemic on the physical activity and screen time habits of children aged 11-13 years in Sweden.", "authors": [{"family": "Berggren", "given": "Sara", "initials": "S"}, {"family": "Almquist-Tangen", "given": "Gerd", "initials": "G"}, {"family": "Wolfbrandt", "given": "Olivia", "initials": "O"}, {"family": "Roswall", "given": "Josefine", "initials": "J"}], "type": "journal article", "published": "2023-08-09", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "1241938"}, "abstract": "Physical activity (PA), exercise, sedentary behavior and screen time are lifestyle factors that have been shown to significantly impact child health in different ways. These lifestyle factors were affected to different degrees by global restrictions during the COVID-19 pandemic. We investigated PA and screen time in a cohort of Swedish children in both 2019 and 2021, before and during the pandemic.\r\n\r\nAdolescents born in 2008 in Halland, Sweden, and included in a previous longitudinal birth cohort study were invited to take part in follow-up questionnaires about PA, screen time and COVID-19. A total of 1041 children aged 11 (in 2019) and 13 years (in 2021) replied and 777 of them answered on both occasions.\r\n\r\nMost children (42.1%) reported that their leisure time PA was unchanged from 2019 to 2021. Compared to unchanged PA 33.9% exercised more often (p = 0.011) and 23.9% exercised less (p < 0.001), both differences statistically significant. Roughly, 43.2% of boys and 34.9% of girls in 2021 exercised so that they became breathless or broke a sweat at least 4 times a week not counting physical education in school, corresponding figures for 2019 were 38.2% for boys and 35.2% for girls. The majority of children were able to continue attending leisure time sports clubs during the pandemic, but participation decreased from 88.3% to 76.3% from 11 to 13 years of age. Most reported that sports club routines changed during the pandemic, but only 40.9% reported fewer practice opportunities. Attending a sports club gave greater protection against loss of PA during the pandemic than not belonging to one (41.0% vs. 23.2%, p < 0.001). The majority (71.1%) of children spent more time on screens in 2021 than 2019, with a mean increase of 9.4 h (95% CI 8.6 to 10.2 h) from 20.7 to 30.1 hours per week (p < 0.001) during the study.\r\n\r\nSwedish children largely maintained their levels of PA during the pandemic at 13 years of age and these were possibly safeguarded by the comparably mild pandemic restrictions in Sweden in 2021. However, they did increase their screen time between 11 and 13 years of age.", "doi": "10.3389/fpubh.2023.1241938", "pmid": "37637825", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10447604"}], "notes": [], "created": "2023-10-05T08:26:38.406Z", "modified": "2023-10-06T05:01:54.058Z"}, {"entity": "publication", "iuid": "170bf933f9e242adac8adf3c85197e5f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/170bf933f9e242adac8adf3c85197e5f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/170bf933f9e242adac8adf3c85197e5f"}}, "title": "Regular Inhaled Corticosteroids Use May Protect Against Severe COVID-19 Outcome in COPD.", "authors": [{"family": "Labor", "given": "Marina", "initials": "M", "orcid": "0000-0001-5216-8129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9a750b29a224b7bb07d535004dfdf15.json"}}, {"family": "Kirui", "given": "Brian K", "initials": "BK", "orcid": "0000-0002-6656-6029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b22b96547b344c79b3780723af1f30e0.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW", "orcid": "0000-0002-4387-4096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bb5d1f761ef48c4837ed4f984717f0e.json"}}], "type": "journal article", "published": "2023-08-07", "journal": {"title": "Int J Chron Obstruct Pulmon Dis", "issn": "1178-2005", "issn-l": null, "volume": "18", "issue": null, "pages": "1701-1712"}, "abstract": "Population-based studies provide conflicting evidence about how inhaled corticosteroids (ICS) impact COVID-19 outcomes among COPD patients. We investigated whether regular ICS exposure affects risk, severity, or survival in SARS-CoV-2 infection, using a nationwide linked Swedish population register database.\r\n\r\nDuring January-December 2020, we studied two defined Swedish adult populations - Whole population [\u226540 years] (N = 5243479), and COPD subpopulation [\u226540 years] (N = 133372), in three study cohorts, respectively: 1. Overall cohort (index date 1 Jan 2020), 2. COVID-19 diagnosed sub-cohort (index date = diagnosis date), and 3. COVID-19 hospitalized sub-cohort (index date = admission date). Regular exposure was defined as \u22653 ICS prescriptions in the year before index. Hazard ratios (HRs) for outcomes (COVID-19 onset, hospitalization, ICU admission, or death) related to ICS exposure were estimated using Cox regression. Confounding was controlled by propensity score methods applying Average Treatment effect in the Treated (ATT) weighting.\r\n\r\nRegular ICS use was associated with only very slightly increased onset of COVID-19, hospitalization, ICU admission, and death in the overall whole population cohort and in the overall COPD subpopulation cohort, except for ICU admission (marginally non-significant HRs, up to 1.13); and no clear increase in the diagnosed sub-cohorts. However, in the COVID-19 hospitalized COPD sub-cohort, ICS therapy showed reduced risks against progression to ICU admission and death, significant for death (HR 0.82 95% CI [0.67-0.99]).\r\n\r\nFor COPD patients, ICS therapy offers some protection against progression to ICU admission and death among COVID-19 hospitalized patients. Our findings alleviate concerns about increased risks of COVID-19 by ICS treatment and provide evidence supporting the continuation of ICS therapy for COPD patients.", "doi": "10.2147/COPD.S404913", "pmid": "37576828", "labels": {"Funder: VR": null, "Category: Public Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC10421743"}, {"db": "pii", "key": "404913"}], "notes": [], "created": "2023-10-05T08:01:51.832Z", "modified": "2023-10-05T08:36:13.679Z"}, {"entity": "publication", "iuid": "90cc886cb05544c79682111b99061687", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90cc886cb05544c79682111b99061687.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90cc886cb05544c79682111b99061687"}}, "title": "Attachment and trauma-informed programme to support forcibly displaced parents of youth in Sweden: feasibility and preliminary outcomes of the eConnect Online programme.", "authors": [{"family": "Kristen", "given": "Anna", "initials": "A", "orcid": "0000-0002-6020-7711", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5c8e51cf2423417a8e0a2c7dc91b423f.json"}}, {"family": "Salari", "given": "Raziye", "initials": "R", "orcid": "0000-0002-6363-4030", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e135f6c46ce47af8be2b490675d4f3f.json"}}, {"family": "Moretti", "given": "Marlene", "initials": "M"}, {"family": "Osman", "given": "Fatumo", "initials": "F", "orcid": "0000-0002-0038-9402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4384d1f8230f4c939d1e5e0025e53013.json"}}], "type": "journal article", "published": "2023-08-07", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "8", "pages": "e072368"}, "abstract": "To assess the feasibility, acceptability and the impact of an online parenting programme for forcibly displaced parents of adolescents.\r\n\r\nThe study was a single-arm feasibility study using pre-intervention post-intervention and follow-up assessments.\r\n\r\nParticipants were recruited from municipality-based activities for refugee parents in a small city in the south of Sweden.\r\n\r\nParticipants were forcibly displaced parents (n=23; 47.8% maternal figures) of youth (n=23; 8-17 years old; 26.1% female) from Syria, Afghanistan and Somalia participating in an online parenting programme (eConnect).\r\n\r\neConnect is an attachment-based and trauma-informed parenting intervention and was delivered over the course of 10 weekly sessions.\r\n\r\nFeasibility was assessed by programme enrolment, attendance, completion and acceptability of the online platform and cultural fit of the programme. Primary outcome measures were programme impact on youth mental health problems. Secondary outcome measures were programme impact on family functioning and parent-child attachment insecurity.\r\n\r\nThe eConnect programme was highly feasible in terms of overall enrolment (100%), attendance (89.6%) and retention rates (100%). The online platform was acceptable, with mixed feedback primarily related to the access and usage of technology. Cultural fit of the programme was acceptable. Youth mental health problems (\u03b7 2=0.29) and family functioning significantly improved (\u03b7 2=0.18) over the course of the programme. Unexpectedly, parent reports of youth attachment insecurity significantly worsened (\u03b7 2=0.16).\r\n\r\nThe findings suggest that the online delivery of Connect was a promising way to reduce barriers to service access and improve mental health problems and family functioning among forcibly displaced parents and their children during COVID-19. Future research is needed to explore the acceptability and impact of this programme post-COVID-19, and to develop culturally tailored and psychometrically sound measures for parent and youth reports of attachment.", "doi": "10.1136/bmjopen-2023-072368", "pmid": "37550024", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10407377"}, {"db": "pii", "key": "bmjopen-2023-072368"}], "notes": [], "created": "2023-10-05T08:26:46.032Z", "modified": "2023-10-06T05:05:48.123Z"}, {"entity": "publication", "iuid": "654c48374d554572b94bcccd5d03900e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/654c48374d554572b94bcccd5d03900e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/654c48374d554572b94bcccd5d03900e"}}, "title": "National trends in depression and suicide attempts and COVID-19 pandemic-related factors, 1998-2021: A nationwide study in South Korea.", "authors": [{"family": "Kang", "given": "Jiseung", "initials": "J"}, {"family": "Park", "given": "Jaeyu", "initials": "J"}, {"family": "Lee", "given": "Hojae", "initials": "H"}, {"family": "Lee", "given": "Myeongcheol", "initials": "M"}, {"family": "Kim", "given": "Sunyoung", "initials": "S"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Smith", "given": "Lee", "initials": "L"}, {"family": "Kim", "given": "Min Seo", "initials": "MS"}, {"family": "Rahmati", "given": "Masoud", "initials": "M"}, {"family": "Fond", "given": "Guillaume", "initials": "G"}, {"family": "Boyer", "given": "Laurent", "initials": "L"}, {"family": "L\u00f3pez S\u00e1nchez", "given": "Guillermo F", "initials": "GF"}, {"family": "Elena", "given": "Dragioti", "initials": "D"}, {"family": "Cortese", "given": "Samuele", "initials": "S"}, {"family": "Kim", "given": "Tae", "initials": "T"}, {"family": "Yon", "given": "Dong Keon", "initials": "DK"}], "type": "journal article", "published": "2023-08-06", "journal": {"title": "Asian J Psychiatr", "issn": "1876-2026", "issn-l": null, "volume": "88", "issue": null, "pages": "103727"}, "abstract": "Despite the significant psychiatric effects of the COVID-19 pandemic, there's limited data on the prevalence and risk factors of depression and suicide attempts among South Korean adults.\r\n\r\nA nationwide cross-sectional study using the Korea National Health and Nutrition Examination Survey (KNHANES) data from 1998 to 2021 was conducted. Changes in prevalence and risk factors for depression and suicide attempts were assessed using weighted odds ratios or weighted beta coefficients.\r\n\r\nDuring the observation period (1998-2021), the prevalence of depression increased in the overall population; however, no significant surge was found regarding the COVID-19 pandemic, from 2.78% (95% CI, 2.41-3.15) in 1998-2005-4.96% (4.32-5.61) in 2020 and 5.06% (4.43-5.69) in 2021. However, immediately after the onset of the pandemic, younger ages, male sex, urban residence, higher education, and high economic status became significant vulnerable factors compared to pre-pandemic periods. The prevalence of suicide attempts remained stable, and there was no notable surge specifically related to the COVID-19 pandemic, from 0.23% (95% CI, 0.18-0.28) in 1998-2005-0.45% (0.25-0.66) in 2020 and 0.42% (0.24-0.60) in 2021. Furthermore, no distinct vulnerable factors associated with suicide attempts have been identified.\r\n\r\nThrough this nationwide serial cross-sectional survey study, we emphasized the need for understanding the differential impacts of global crises, such as COVID-19, across varied population subgroups, thereby highlighting the importance of specific and targeted mental health support strategies.", "doi": "10.1016/j.ajp.2023.103727", "pmid": "37633158", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S1876-2018(23)00283-6"}], "notes": [], "created": "2023-10-05T08:26:14.345Z", "modified": "2023-10-06T04:52:01.848Z"}, {"entity": "publication", "iuid": "f910f94cd1d24cac87d244b467352d0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f910f94cd1d24cac87d244b467352d0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f910f94cd1d24cac87d244b467352d0e"}}, "title": "COVID-19 among migrants, refugees, and internally displaced persons: systematic review, meta-analysis and qualitative synthesis of the global empirical literature", "authors": [{"family": "Hintermeier", "given": "Maren", "initials": "M"}, {"family": "Gottlieb", "given": "Nora", "initials": "N"}, {"family": "Rohleder", "given": "Sven", "initials": "S"}, {"family": "Oppenberg", "given": "Jan", "initials": "J"}, {"family": "Baroudi", "given": "Mazen", "initials": "M"}, {"family": "Pernitez-Agan", "given": "Sweetmavourneen", "initials": "S"}, {"family": "Lopez", "given": "Janice", "initials": "J"}, {"family": "Flores", "given": "Sergio", "initials": "S"}, {"family": "Mohsenpour", "given": "Amir", "initials": "A", "orcid": "0000-0001-8419-2430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45c5089d3d844b86b2556c2405d3bdba.json"}}, {"family": "Wickramage", "given": "Kolitha", "initials": "K"}, {"family": "Bozorgmehr", "given": "Kayvan", "initials": "K", "orcid": "0000-0002-1411-1209", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d618d677fbb34dccb3439d863b131350.json"}}], "type": "posted-content", "published": "2023-08-06", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.08.03.23293586", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:02:28.486Z", "modified": "2023-10-05T08:44:03.578Z"}, {"entity": "publication", "iuid": "3097f975fd2649e4b28e4007f8b731b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3097f975fd2649e4b28e4007f8b731b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3097f975fd2649e4b28e4007f8b731b1"}}, "title": "Alcohol, drug and tobacco prevention in Swedish municipalities - impact from the COVID-19 pandemic considering socio-demographic context.", "authors": [{"family": "Owen", "given": "Ulrika", "initials": "U"}, {"family": "M\u00e5nsdotter", "given": "Anna", "initials": "A"}, {"family": "Guldbrandsson", "given": "Karin", "initials": "K"}, {"family": "Lindstr\u00f6m", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2023-08-04", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": null, "issue": null, "pages": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic and measures to prevent the spread of the virus challenged public health practice at the local level in Sweden. The objective of this study was to explore the impact of the pandemic on the prevention of alcohol, drugs and tobacco (ADT) in Sweden during 2020-21 considering socio-demographic context.\r\n\r\nData were collected through the Public Health Agency's survey on ADT prevention in Swedish municipalities (N = 290). This study used data from 2020 and 2021, with a response rate of 90% and 88%, respectively. Survey data were analyzed in logistic regression models (odds ratios, P < 0.05, 95% confidence intervals) against variables of education level, income level and population size from national registers.\r\n\r\nA majority (n = 198, 76%) of the municipalities reported a decrease in ADT prevention during the pandemic. No correlation between the decrease in ADT prevention and socio-demographic conditions was detected. A majority (2020: n = 165, 63%; 2021: n = 174, 68%) of the municipalities also reported that ADT prevention was adapted, however less common in smaller municipalities and municipalities where residents had lower levels of education and lower incomes.\r\n\r\nADT prevention carried out by municipalities in Sweden was initially (2020) deeply affected by the preventive strategies against COVID-19. Adaptation of activities was less common in municipalities with more vulnerable socio-demographic situation. In policy, practice and research, the findings are important not only for continued progress on the national goal of equity in health but also for preparedness for future crises.", "doi": "10.1093/eurpub/ckad127", "pmid": "37541832", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "7237445"}], "notes": [], "created": "2023-10-05T08:26:09.552Z", "modified": "2023-10-06T04:48:21.765Z"}, {"entity": "publication", "iuid": "b025ee64be20412b8be8a8a218882fa0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b025ee64be20412b8be8a8a218882fa0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b025ee64be20412b8be8a8a218882fa0"}}, "title": "Acceptability of restrictions in the COVID-19 pandemic: a population-based survey in Denmark and Sweden.", "authors": [{"family": "Nilsen", "given": "Per", "initials": "P"}, {"family": "Seing", "given": "Ida", "initials": "I"}, {"family": "Sekhon", "given": "Mandeep", "initials": "M"}, {"family": "Kallemose", "given": "Thomas", "initials": "T"}, {"family": "Tj\u00f8rnh\u00f8j-Thomsen", "given": "Tine", "initials": "T"}, {"family": "Stef\u00e1nsd\u00f3ttir", "given": "Nina Th\u00f3rn\u00fd", "initials": "NT"}, {"family": "Vrangb\u00e6k", "given": "Karsten", "initials": "K"}, {"family": "Andersen", "given": "Ove", "initials": "O"}, {"family": "Kirk", "given": "Jeanette Wassar", "initials": "JW"}], "type": "journal article", "published": "2023-08-03", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "988882"}, "abstract": "Denmark and Sweden initially adopted different responses to the COVID-19 pandemic although the two countries share many characteristics. Denmark responded swiftly with many mandatory restrictions. In contrast, Sweden relied on voluntary restrictions and a more \"relaxed\" response during the first wave of the pandemic. However, increased rates of COVID-19 cases led to a new approach that involved many more mandatory restrictions, thus making Sweden's response similar to Denmark's in the second wave of the pandemic.\r\n\r\nThe aim was to investigate and compare the extent to which the populations in Denmark and Sweden considered the COVID-19 restrictions to be acceptable during the first two waves of the pandemic. The study also aimed to identify the characteristics of those who were least accepting of the restrictions in the two countries.\r\n\r\nCross-sectional surveys were conducted in Denmark and Sweden in 2021. The study population was sampled from nationally representative web panels in the two countries, consisting of 2,619 individuals from Denmark and 2,633 from Sweden. The questionnaire captured key socio-demographic characteristics. Acceptability was operationalized based on a theoretical framework consisting of seven constructs and one overarching construct.\r\n\r\nThe respondents' age and gender patterns were similar in the two countries. The proportion of respondents in Denmark who agreed with the statements (\"agree\" alternative) that captured various acceptability constructs was generally higher for the first wave than the second wave of the pandemic. The opposite pattern was seen for Sweden. In Denmark, 66% in the first wave and 50% in the second wave were accepting of the restrictions. The corresponding figures for Sweden was 42% (first wave) and 47% (second wave). Low acceptance of the restrictions, defined as the 25% with the lowest total score on the seven acceptability statements, was associated with younger age, male gender and lower education levels.\r\n\r\nRespondents in Sweden were more accepting of the restrictions in the second wave, when the country used many mandatory restrictions. In contrast, respondents in Denmark were more accepting of the restrictions in the first wave than in the second wave, implying an increased weariness to comply with the restrictions over time. There were considerable socio-demographic differences between those who expressed low acceptance of the restrictions and the others in both countries, suggesting the importance of tailoring communication about the pandemic to different segments of the population.", "doi": "10.3389/fpubh.2023.988882", "pmid": "37601192", "labels": {"Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10434523"}], "notes": [], "created": "2023-10-05T08:26:33.525Z", "modified": "2023-10-06T04:59:24.120Z"}, {"entity": "publication", "iuid": "d50f06e75b39478fa4be8f1aef867936", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d50f06e75b39478fa4be8f1aef867936.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d50f06e75b39478fa4be8f1aef867936"}}, "title": "Waves of inequality: income differences in intensive care due to Covid-19 in Sweden.", "authors": [{"family": "Gauffin", "given": "Karl", "initials": "K", "orcid": "0000-0001-9349-9936", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40b610dc330245929d1c3ea558ef9af4.json"}}, {"family": "\u00d6stergren", "given": "Olof", "initials": "O", "orcid": "0000-0002-7156-3260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d22b6331dfb4bd88e2935d0ddec1dd3.json"}}, {"family": "Cederstr\u00f6m", "given": "Agneta", "initials": "A"}], "type": "journal article", "published": "2023-08-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": "33", "issue": "4", "pages": "574-579"}, "abstract": "Socioeconomically vulnerable groups were overall more likely to develop severe Covid-19, but specific conditions in terms of preparedness, knowledge and the properties of the virus itself changed during the course of the pandemic. Inequalities in Covid-19 may therefore shift over time. This study examines the relationship between income and intensive care (ICU) episodes due to Covid-19 in Sweden during three distinct waves.\r\n\r\nThis study uses Swedish register data on the total adult population and estimates the relative risk (RR) of ICU episodes due to Covid-19 by income quartile for each month between March 2020 and May 2022, and for each wave, using Poisson regression analyses.\r\n\r\nThe first wave had modest income-related inequalities, while the second wave had a clear income gradient, with the lowest income quartile having an increased risk compared to the high-income group [RR: 1.55 (1.36-1.77)]. In the third wave, the overall need for ICU decreased, but RRs increased, particularly in the lowest income quartile [RR: 3.72 (3.50-3.96)]. Inequalities in the third wave were partly explained by differential vaccination coverage by income quartile, although substantial inequalities remained after adjustment for vaccination status [RR: 2.39 (2.20-2.59)].\r\n\r\nThe study highlights the importance of considering the changing mechanisms that connect income and health during a novel pandemic. The finding that health inequalities increased as the aetiology of Covid-19 became better understood could be interpreted through the lens of adapted fundamental cause theory.", "doi": "10.1093/eurpub/ckad094", "pmid": "37322545", "labels": {"Category: Social Science & Humanities": null, "Funder: Forte": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10393505"}, {"db": "pii", "key": "7199199"}], "notes": [], "created": "2023-10-04T09:30:28.649Z", "modified": "2023-10-04T09:56:34.789Z"}, {"entity": "publication", "iuid": "4844edf1bca7409c8a29d94b9035ba7c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4844edf1bca7409c8a29d94b9035ba7c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4844edf1bca7409c8a29d94b9035ba7c"}}, "title": "Trajectory of COVID-19 vaccine hesitancy post-vaccination and public's intention to take booster vaccines: A cross-sectional analysis.", "authors": [{"family": "Salman", "given": "Muhammad", "initials": "M"}, {"family": "Mallhi", "given": "Tauqeer Hussain", "initials": "TH"}, {"family": "Khan", "given": "Yusra Habib", "initials": "YH"}, {"family": "Mustafa", "given": "Zia Ul", "initials": "ZU"}, {"family": "Khan", "given": "Muhammad Tanveer", "initials": "MT"}, {"family": "Khan", "given": "Faiz Ullah", "initials": "FU"}, {"family": "Butt", "given": "Muhammad Hammad", "initials": "MH", "orcid": "0000-0003-4387-1351", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6671444d83444ea2a1c68fcb309b6338.json"}}, {"family": "Shehzadi", "given": "Naureen", "initials": "N"}, {"family": "Farrukh", "given": "Muhammad Junaid", "initials": "MJ"}, {"family": "Waheed", "given": "Maria", "initials": "M"}, {"family": "Azmat", "given": "Fatima", "initials": "F"}, {"family": "Saeed", "given": "Areej", "initials": "A"}, {"family": "Mazhar", "given": "Syeda Ayesha", "initials": "SA"}, {"family": "Ali", "given": "Asim", "initials": "A"}, {"family": "Ashfaq", "given": "Aisha", "initials": "A"}, {"family": "Hussain", "given": "Khalid", "initials": "K"}], "type": "journal article", "published": "2023-08-01", "journal": {"title": "Hum Vaccin Immunother", "issn": "2164-554X", "issn-l": null, "volume": "19", "issue": "2", "pages": "2225990"}, "abstract": "Vaccine hesitancy (VH) is not a new phenomenon in Pakistan and is regarded as one of the primary causes of unsatisfactory vaccination campaigns. This study determined post-vaccination COVID-19 VH, factors influencing COVID-19 vaccine uptake, and public's intent to receive booster vaccinations. A cross-sectional study was conducted among adult population of Lahore, Pakistan. Participants were recruited via convenience sampling between March and May 2022. SPSS version 22 was used for the data analysis. A total of 650 participants were included in the study (age = 28.1 \u00b1 9.7 years; male-to-female ratio nearly 1: 1). The majority of participants received Sinopharm followed by Sinovac vaccine. The top three reasons of vaccine uptake were \"only vaccinated individuals are allowed at the workplace, and educational institutes\" (Relative importance index (RII) = 0.749), \"only vaccinated people are allowed to go to markets, malls and other public places\" (RII = 0.746), and \"protect myself from the infection\" (RII = 0.742). The mean COVID-19 VH score was 24.5 \u00b1 6.2 (95% CI 23.9-24.9), with not being pro-vaccines and poor economic status were the significant predictors of COVID-19 vaccine hesitancy among immunized individuals (p < .05). Acceptance of booster vaccines was negatively associated with younger age and a lower level of education. Furthermore, being pro-vaccine was associated with a greater likelihood of accepting booster vaccines (p = .001). The Pakistani public continues to express VH toward COVID-19 vaccines. Therefore, aggressive measures must be taken to combat the community factors that contribute to it.", "doi": "10.1080/21645515.2023.2225990", "pmid": "37350298", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10332231"}], "notes": [], "created": "2023-10-04T09:31:38.960Z", "modified": "2023-10-04T10:51:23.112Z"}, {"entity": "publication", "iuid": "c58419bfaf374d5ea21b7e947d6e9f8c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c58419bfaf374d5ea21b7e947d6e9f8c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c58419bfaf374d5ea21b7e947d6e9f8c"}}, "title": "Symptoms of depression and anxiety among elite high school student-athletes in Sweden during the COVID-19 pandemic: A repeated cross-sectional study.", "authors": [{"family": "Andersson", "given": "Mitchell J", "initials": "MJ", "orcid": "0000-0002-4753-016X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/574c35f21dad4cdea3510e7fd446cd94.json"}}, {"family": "Kentt\u00e4", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0002-9921-6586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bd3e6dbe34a41eaad16944e0de23c70.json"}}, {"family": "Moesch", "given": "Karin", "initials": "K", "orcid": "0000-0001-6500-182X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/339f5d2f86d94553b0c95483ab7f832c.json"}}, {"family": "Borg", "given": "Elisabet", "initials": "E", "orcid": "0000-0002-7638-347X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/222e6cd7574241d6b963df4c8e4082d1.json"}}, {"family": "Claesdotter-Knutsson", "given": "Emma", "initials": "E", "orcid": "0000-0002-6832-2482", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8738736985b40b3bdf49061f734f62f.json"}}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A", "orcid": "0000-0002-5800-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec14ecdcc0654d8ea864f64ce195752b.json"}}], "type": "journal article", "published": "2023-08-01", "journal": {"title": "J Sports Sci", "issn": "1466-447X", "issn-l": null, "volume": null, "issue": null, "pages": "1-10"}, "abstract": "The COVID-19 pandemic precipitated numerous changes in daily life, including the cancellation and restriction of sports globally. Because sports participation contributes positively to the development of student-athletes, restricting these activities may have led to long-term mental health changes in this population. Using a repeated cross-sectional study design, we measured rates of depression using the Patient Health Questionnaire-2 and anxiety using the Generalized Anxiety Disorder-2 scale in student-athletes attending elite sport high schools in Sweden during the second wave of the pandemic (February 2021; n = 7021) and after all restrictions were lifted (February 2022; n = 6228). Depression among student-athletes decreased from 19.8% in 2021 to 17.8% in 2022 (p = .008, V = .026), while anxiety screening did not change significantly (17.4% to 18.4%, p > .05). Comparisons between classes across years revealed older students exhibited decreases in depressive symptoms, while younger cohorts experienced increases in symptoms of anxiety from 2021 to 2022. Logistic regressions revealed that being female, reporting poorer mental health due to COVID-19, and excessive worry over one's career in sports were significant predictors of both depression and anxiety screenings in 2022. Compared to times when sports participation was limited, the lifting of restrictions was associated with overall reduced levels of depression, but not anxiety.", "doi": "10.1080/02640414.2023.2241783", "pmid": "37527354", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:26:06.817Z", "modified": "2023-10-06T04:46:42.217Z"}, {"entity": "publication", "iuid": "9fe286063aa7428b9c72813afeff6bf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9fe286063aa7428b9c72813afeff6bf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9fe286063aa7428b9c72813afeff6bf3"}}, "title": "COVID-19 vaccine hesitancy among first-generation immigrants living in Sweden.", "authors": [{"family": "Svallfors", "given": "Signe", "initials": "S", "orcid": "0000-0002-8413-1731", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2f5b34aae664a159d64182ad0f6517c.json"}}, {"family": "Larsson", "given": "Elin C", "initials": "EC"}, {"family": "Puranen", "given": "Bi", "initials": "B"}, {"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM"}], "type": "journal article", "published": "2023-08-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": "33", "issue": "4", "pages": "687-694"}, "abstract": "In many countries, immigrants face higher risks of contracting and dying from COVID-19 compared with the native-born population. Moreover, their COVID-19 vaccination uptake tends to be lower. This study aimed to investigate COVID-19 vaccine hesitancy in relation to sociodemographic characteristics, COVID-19-related exposures and social values, norms and perceptions among first-generation immigrants in Sweden. Vaccine hesitancy is an important public health issue to ensure protection against vaccine-preventable mortality and morbidity.\r\n\r\nNation-wide representative data were collected by the Migrant World Values Survey. Descriptive and multinomial multivariate analyses were performed to analyze vaccine hesitancy among 2612 men and women aged \u226516 years.\r\n\r\nOne-quarter of the respondents expressed some degree of vaccine hesitancy; 5% said they would definitely not vaccinate, 7% probably not, 4% did not know and 7% did not want to answer. Young age, arriving to Sweden during the large migration wave in 2015, Eastern European origin, female gender, lower education and low trust in authorities, and less perceived benefits of vaccination were all significant determinants of vaccine hesitancy.\r\n\r\nThe results underscore the importance of trust in healthcare providers and government authorities. Additionally, the importance of providing adequate and targeted information about vaccination to groups who face the largest barriers to care, enabling informed decision-making about the benefits and risks of vaccination in relation to health risks. Given these health risks, it is crucial that government agencies and the health sector address the multiple social dimensions that shape the low vaccine uptake and, in turn, health equity.", "doi": "10.1093/eurpub/ckad073", "pmid": "37229599", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10395762"}, {"db": "pii", "key": "7179915"}], "notes": [], "created": "2023-10-04T05:09:41.008Z", "modified": "2023-10-04T06:05:56.142Z"}, {"entity": "publication", "iuid": "5a7add59b3cd4d1c9ddce8fc1b59912e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5a7add59b3cd4d1c9ddce8fc1b59912e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5a7add59b3cd4d1c9ddce8fc1b59912e"}}, "title": "Were cancer patients worse off than the general population during the COVID-19 pandemic? A population-based study from Norway, Denmark and Iceland during the pre-vaccination era.", "authors": [{"family": "Johansson", "given": "Anna L V", "initials": "ALV"}, {"family": "Skog", "given": "Anna", "initials": "A"}, {"family": "Johannesen", "given": "Tom B\u00f8rge", "initials": "TB"}, {"family": "Myklebust", "given": "Tor \u00c5ge", "initials": "T\u00c5"}, {"family": "Skovlund", "given": "Charlotte Wessel", "initials": "CW"}, {"family": "M\u00f8rch", "given": "Lina Steinrud", "initials": "LS"}, {"family": "Friis", "given": "S\u00f8ren", "initials": "S"}, {"family": "Gamborg", "given": "Mads", "initials": "M"}, {"family": "Kristiansen", "given": "Marnar Fr\u00ed\u00f0heim", "initials": "MF"}, {"family": "Pettersson", "given": "David", "initials": "D"}, {"family": "\u00d3lafsd\u00f3ttir", "given": "El\u00ednborg J", "initials": "EJ"}, {"family": "Birgisson", "given": "Helgi", "initials": "H"}, {"family": "Palsson", "given": "Runolfur", "initials": "R"}, {"family": "Eythorsson", "given": "Elias", "initials": "E"}, {"family": "Irenaeus", "given": "Sandra", "initials": "S"}, {"family": "Lambe", "given": "Mats", "initials": "M"}, {"family": "Ursin", "given": "Giske", "initials": "G"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "issn-l": null, "volume": "31", "issue": null, "pages": "100680"}, "abstract": "In a population-based setting, we investigated the risks of testing positive for SARS-CoV-2 and developing severe COVID-19 outcomes among cancer patients compared with the general population.\r\n\r\nIn nationwide cohorts, we identified all individuals in Norway, Denmark and Iceland who tested positive for SARS-CoV-2 or had a severe COVID-19 outcome (hospitalisation, intensive care, and death) from March until December 2020, using data from national health registries. We estimated standardised incidence ratios (SIRs) with 95% confidence intervals (CIs) comparing cancer patients with the general population.\r\n\r\nDuring the first wave of the pandemic, cancer patients in Norway and Denmark had higher risks of testing SARS-CoV-2 positive compared to the general population. Throughout 2020, recently treated cancer patients were more likely to test SARS-CoV-2 positive. In Iceland, cancer patients experienced no increased risk of testing positive. The risk of COVID-19-related hospitalisation was higher among cancer patients diagnosed within one year of hospitalisation (Norway: SIR = 2.43, 95% CI 1.89-3.09; Denmark: 2.23, 1.96-2.54) and within five years (Norway: 1.58, 1.35-1.83; Denmark: 1.54, 1.42-1.66). Risks were higher in recently treated cancer patients and in those diagnosed with haematologic malignancies, colorectal or lung cancer. Risks of COVID-19-related intensive care and death were higher among cancer patients.\r\n\r\nCancer patients were at increased risk of testing positive for SARS-CoV-2 during the first pandemic wave when testing availability was limited, while relative risks of severe COVID-19 outcomes remained increased in cancer patients throughout 2020. Recent cancer treatment and haematologic malignancy were the strongest risk factors.\r\n\r\nNordic Cancer Union.", "doi": "10.1016/j.lanepe.2023.100680", "pmid": "37547277", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10398597"}, {"db": "pii", "key": "S2666-7762(23)00099-6"}], "notes": [], "created": "2023-10-05T08:01:39.277Z", "modified": "2023-10-05T08:29:59.698Z"}, {"entity": "publication", "iuid": "be720cf5d37342279078fa4d9c77d8b5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be720cf5d37342279078fa4d9c77d8b5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be720cf5d37342279078fa4d9c77d8b5"}}, "title": "The kinetics of SARS-CoV-2 viremia in COVID-19 patients receiving remdesivir.", "authors": [{"family": "Krifors", "given": "Anders", "initials": "A", "orcid": "0000-0003-1230-0492", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea4a8b6ff4ab4b10915071a561af110e.json"}}, {"family": "Karlsson", "given": "Linda", "initials": "L"}, {"family": "Ekman", "given": "Martin", "initials": "M"}, {"family": "Lorant", "given": "Camilla", "initials": "C"}, {"family": "Skorup", "given": "Paul", "initials": "P"}], "type": "observational study", "published": "2023-08-00", "journal": {"title": "Eur J Clin Microbiol Infect Dis", "issn": "1435-4373", "issn-l": null, "volume": "42", "issue": "8", "pages": "951-958"}, "abstract": "Detection of SARS-CoV-2 RNA in serum, viremia, has been linked to disease severity and outcome. The kinetics of viremia in patients receiving remdesivir has not been thoroughly studied and could help predict treatment response and outcome. We investigated the kinetics of SARS-CoV-2 viremia and factors associated with baseline viremia, viral clearance and 30-day mortality in patients receiving remdesivir. An observational study including 378 hospitalised patients (median age 67 years, 67% male) sampled with serum SARS-CoV-2 RT-PCR within \u00b1 24 h of initiation of remdesivir treatment. Baseline viremia was present in 206 (54%) patients with a median Ct value of 35.3 (IQR = 33.3-37.1). In patients with baseline viremia, the estimated probability of viral clearance was 72% by day 5. Ct values decreased significantly during remdesivir treatment for viremic patients, indicating an increase in viral load. In total, 44 patients (12%) died within 30 days, and mortality was significantly associated with viremia at baseline (OR = 2.45, p = 0.01) and lack of viral clearance by day 5 (OR = 4.8, p = < 0.01). Viral clearance was not associated with any individual risk factor. Viremia appears to be a prognostic marker before and during remedesivir treatment. The resolution of viremia was similar to patients not receiving remdesivir in other studies, and the decrease in Ct values during treatment questions the antiviral capacity of remdesivir in vivo. Prospective studies are warranted to confirm our findings.", "doi": "10.1007/s10096-023-04627-4", "pmid": "37243828", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10224642"}, {"db": "pii", "key": "10.1007/s10096-023-04627-4"}], "notes": [], "created": "2023-10-04T05:11:26.703Z", "modified": "2023-10-04T07:12:25.753Z"}, {"entity": "publication", "iuid": "79763b12a76d49b1b9f24d19c77829db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79763b12a76d49b1b9f24d19c77829db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79763b12a76d49b1b9f24d19c77829db"}}, "title": "Spontaneous Resolution of Uncomplicated Appendicitis may Explain Increase in Proportion of Complicated Appendicitis During Covid-19 Pandemic: a Systematic Review and Meta-analysis.", "authors": [{"family": "Andersson", "given": "Roland E", "initials": "RE", "orcid": "0000-0002-1460-0248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/63ebde95890245d58691f0d69acbbcc5.json"}}, {"family": "Agiorgiti", "given": "Maria", "initials": "M"}, {"family": "Bendtsen", "given": "Marcus", "initials": "M"}], "type": "meta-analysis", "published": "2023-08-00", "journal": {"title": "World J Surg", "issn": "1432-2323", "issn-l": null, "volume": "47", "issue": "8", "pages": "1901-1916"}, "abstract": "Reports of an increased proportion of complicated appendicitis during the Covid-19 pandemic suggest a worse outcome due to delay secondary to the restrained access to health care, but may be explained by a concomitant decrease in uncomplicated appendicitis. We analyze the impact of the pandemic on the incidences of complicated and uncomplicated appendicitis.\r\n\r\nWe did a systematic literature search in the PubMed, Embase and Web Of Science databases on December 21, 2022 with the search terms (appendicitis OR appendectomy) AND (\"COVID\" OR SARS-Cov2 OR \"coronavirus\"). Studies reporting the number of complicated and uncomplicated appendicitis during identical calendar periods in 2020 and the pre-pandemic year(s) were included. Reports with indications suggesting a change in how the patients were diagnosed and managed between the two periods were excluded. No protocol was prepared in advance. We did random effects meta-analysis of the change in proportion of complicated appendicitis, expressed as the risk ratio (RR), and of the change in number of patients with complicated and uncomplicated appendicitis during the pandemic compared with pre-pandemic periods, expressed as the incidence ratio (IR). We did separate analyses for studies based on single- and multi-center and regional data, age-categories and prehospital delay.\r\n\r\nThe meta-analysis of 100,059 patients in 63 reports from 25 countries shows an increase in the proportion of complicated appendicitis during the pandemic period (RR 1.39, 95% confidence interval (95% CI 1.25, 1.53). This was mainly explained by a decreased incidence of uncomplicated appendicitis (incidence ratio (IR) 0.66, 95% CI 0.59, 0.73). No increase in complicated appendicitis was seen in multi-center and regional reports combined (IR 0.98, 95% CI 0.90, 1.07).\r\n\r\nThe increased proportion of complicated appendicitis during Covid-19 is explained by a decrease in the incidence of uncomplicated appendicitis, whereas the incidence of complicated appendicitis remained stable. This result is more evident in the multi-center and regional based reports. This suggests an increase in spontaneously resolving appendicitis due to the restrained access to health care. This has important principal implications for the management of patients with suspected appendicitis.", "doi": "10.1007/s00268-023-07027-z", "pmid": "37140609", "labels": {"Category: Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC10158710"}, {"db": "pii", "key": "10.1007/s00268-023-07027-z"}], "notes": [], "created": "2023-10-04T05:11:43.715Z", "modified": "2023-10-04T07:21:04.378Z"}, {"entity": "publication", "iuid": "5f91d408d52142f4b03f19b0f95c8e51", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f91d408d52142f4b03f19b0f95c8e51.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f91d408d52142f4b03f19b0f95c8e51"}}, "title": "Revisiting the personal protective equipment components of transmission-based precautions for the prevention of COVID-19 and other respiratory virus infections in healthcare.", "authors": [{"family": "Plachouras", "given": "Diamantis", "initials": "D"}, {"family": "Kacelnik", "given": "Oliver", "initials": "O"}, {"family": "Rodr\u00edguez-Ba\u00f1o", "given": "Jes\u00fas", "initials": "J"}, {"family": "Birgand", "given": "Gabriel", "initials": "G"}, {"family": "Borg", "given": "Michael A", "initials": "MA"}, {"family": "Kristensen", "given": "Brian", "initials": "B"}, {"family": "Kubele", "given": "Jan", "initials": "J"}, {"family": "Lyytik\u00e4inen", "given": "Outi", "initials": "O"}, {"family": "Presterl", "given": "Elisabeth", "initials": "E"}, {"family": "Reilly", "given": "Jacqui", "initials": "J"}, {"family": "Voss", "given": "Andreas", "initials": "A"}, {"family": "Zingg", "given": "Walter", "initials": "W"}, {"family": "Suetens", "given": "Carl", "initials": "C"}, {"family": "Monnet", "given": "Dominique L", "initials": "DL"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "32", "pages": null}, "abstract": "The COVID-19 pandemic highlighted some potential limitations of transmission-based precautions. The distinction between transmission through large droplets vs aerosols, which have been fundamental concepts guiding infection control measures, has been questioned, leading to considerable variation in expert recommendations on transmission-based precautions for COVID-19. Furthermore, the application of elements of contact precautions, such as the use of gloves and gowns, is based on low-quality and inconclusive evidence and may have unintended consequences, such as increased incidence of healthcare-associated infections and spread of multidrug-resistant organisms. These observations indicate a need for high-quality studies to address the knowledge gaps and a need to revisit the theoretical background regarding various modes of transmission and the definitions of terms related to transmission. Further, we should examine the implications these definitions have on the following components of transmission-based precautions: (i) respiratory protection, (ii) use of gloves and gowns for the prevention of respiratory virus infections, (iii) aerosol-generating procedures and (iv) universal masking in healthcare settings as a control measure especially during seasonal epidemics. Such a review would ensure that transmission-based precautions are consistent and rationally based on available evidence, which would facilitate decision-making, guidance development and training, as well as their application in practice.", "doi": "10.2807/1560-7917.ES.2023.28.32.2200718", "pmid": "37561052", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10416576"}], "notes": [], "created": "2023-10-05T08:26:43.514Z", "modified": "2023-10-06T05:04:46.750Z"}, {"entity": "publication", "iuid": "ec036f75d2c84f21a9062b37be23a7bc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec036f75d2c84f21a9062b37be23a7bc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec036f75d2c84f21a9062b37be23a7bc"}}, "title": "Relative effectiveness of bivalent Original/Omicron BA.4-5 mRNA vaccine in preventing severe COVID-19 in persons 60 years and above during SARS-CoV-2 Omicron XBB.1.5 and other XBB sublineages circulation, Italy, April to June 2023.", "authors": [{"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Sacco", "given": "Chiara", "initials": "C"}, {"family": "Rota", "given": "Maria Cristina", "initials": "MC"}, {"family": "Fotakis", "given": "Emmanouil Alexandros", "initials": "EA"}, {"family": "Petrone", "given": "Daniele", "initials": "D"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Siddu", "given": "Andrea", "initials": "A"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Rezza", "given": "Giovanni", "initials": "G"}, {"family": "Palamara", "given": "Anna Teresa", "initials": "AT"}, {"family": "Brusaferro", "given": "Silvio", "initials": "S"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Italian Integrated Surveillance of COVID-19 study group and of the Italian COVID-19 Vaccines Registry group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "32", "pages": null}, "abstract": "During predominant circulation of SARS-CoV-2 Omicron XBB.1.5 and other XBB sublineages (April-June 2023), we found that a second or third booster of Comirnaty bivalent Original/Omicron BA.4-5 mRNA vaccine, versus a first booster received at least 120 days earlier, was effective in preventing severe COVID-19 for more than 6 months post-administration in persons 60 years and above. In view of autumn 2023 vaccination campaigns, use of bivalent Original/Omicron BA.4-5 mRNA vaccines might be warranted until monovalent COVID-19 vaccines targeting Omicron XBB.1 sublineages become available.", "doi": "10.2807/1560-7917.ES.2023.28.32.2300397", "pmid": "37561053", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10416574"}], "notes": [], "created": "2023-10-05T08:01:48.314Z", "modified": "2023-10-05T08:35:00.591Z"}, {"entity": "publication", "iuid": "60c4d930bc3a4ff78361a04cabad8596", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60c4d930bc3a4ff78361a04cabad8596.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60c4d930bc3a4ff78361a04cabad8596"}}, "title": "Real-world assessment of immunogenicity in immunocompromised individuals following SARS-CoV-2 mRNA vaccination: a one-year follow-up of the prospective clinical trial COVAXID.", "authors": [{"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Mielke", "given": "Stephan", "initials": "S"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "S\u00f6derdahl", "given": "Gunnar", "initials": "G"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE"}, {"family": "Vesterbacka", "given": "Jan", "initials": "J"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": "94", "issue": null, "pages": "104700"}, "abstract": "Immunocompromised patients have varying responses to SARS-CoV-2 mRNA vaccination. However, there is limited information available from prospective clinical trial cohorts with respect to long-term immunogenicity-related responses in these patient groups following three or four vaccine doses, and in applicable cases infection.\r\n\r\nIn a real-world setting, we assessed the long-term immunogenicity-related responses in patients with primary and secondary immunodeficiencies from the prospective open-label clinical trial COVAXID. The original clinical trial protocol included two vaccine doses given on days 0 and 21, with antibody titres measured at six different timepoints over six months. The study cohort has subsequently been followed for one year with antibody responses evaluated in relation to the third and fourth vaccine dose, and in applicable cases SARS-CoV-2 infection. In total 356/539 patients were included in the extended cohort. Blood samples were analysed for binding antibody titres and neutralisation against the Spike protein for all SARS-CoV-2 variants prevailing during the study period, including Omicron subvariants. SARS-CoV-2 infections that did not require hospital care were recorded through quarterly in-person, or phone-, interviews and assessment of IgG antibody titres against SARS-CoV-2 Nucleocapsid. The original clinical trial was registered in EudraCT (2021-000175-37) and clinicaltrials.gov (NCT04780659).\r\n\r\nThe third vaccine dose significantly increased Spike IgG titres against all the SARS-CoV-2 variants analysed in all immunocompromised patient groups. Similarly, neutralisation also increased against all variants studied, except for Omicron. Omicron-specific neutralisation, however, increased after a fourth dose as well as after three doses and infection in many of the patient subgroups. Noteworthy, however, while many patient groups mounted strong serological responses after three and four vaccine doses, comparably weak responders were found among patient subgroups with specific primary immunodeficiencies and subgroups with immunosuppressive medication.\r\n\r\nThe study identifies particularly affected patient groups in terms of development of long-term immunity among a larger group of immunocompromised patients. In particular, the results highlight poor vaccine-elicited neutralising responses towards Omicron subvariants in specific subgroups. The results provide additional knowledge of relevance for future vaccination strategies.\r\n\r\nThe present studies were supported by grants from the Swedish Research Council, the Knut and Alice Wallenberg Foundation, Nordstjernan AB, Region Stockholm, and Karolinska Institutet.", "doi": "10.1016/j.ebiom.2023.104700", "pmid": "37453361", "labels": {"Funder: VR": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10365982"}, {"db": "pii", "key": "S2352-3964(23)00265-7"}, {"db": "ClinicalTrials.gov", "key": "NCT04780659"}], "notes": [], "created": "2023-10-04T12:09:39.916Z", "modified": "2023-10-04T13:00:45.794Z"}, {"entity": "publication", "iuid": "d860da70e0254d6caaa6e69953ce5b58", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d860da70e0254d6caaa6e69953ce5b58.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d860da70e0254d6caaa6e69953ce5b58"}}, "title": "Protection against COVID-19 hospitalisation conferred by primary-series vaccination with AZD1222 in non-boosted individuals: first vaccine effectiveness results of the European COVIDRIVE study and meta-regression analysis.", "authors": [{"family": "Meeraus", "given": "Wilhelmine", "initials": "W"}, {"family": "de Munter", "given": "Leonie", "initials": "L"}, {"family": "Gray", "given": "Christen M", "initials": "CM"}, {"family": "Dwivedi", "given": "Akshat", "initials": "A"}, {"family": "Wyndham-Thomas", "given": "Chlo\u00e9", "initials": "C"}, {"family": "Ouwens", "given": "Mario", "initials": "M"}, {"family": "Hartig-Merkel", "given": "Wendy", "initials": "W"}, {"family": "Drikite", "given": "Laura", "initials": "L"}, {"family": "Rebry", "given": "Griet", "initials": "G"}, {"family": "Carmona", "given": "Antonio", "initials": "A"}, {"family": "Stuurman", "given": "Anke L", "initials": "AL"}, {"family": "Chi Nguyen", "given": "Thi Yen", "initials": "TY"}, {"family": "Mena", "given": "Guillermo", "initials": "G"}, {"family": "Mira-Iglesias", "given": "Ainara", "initials": "A"}, {"family": "Icardi", "given": "Giancarlo", "initials": "G"}, {"family": "Otero-Romero", "given": "Susana", "initials": "S"}, {"family": "Baumgartner", "given": "Sebastian", "initials": "S"}, {"family": "Martin", "given": "Charlotte", "initials": "C"}, {"family": "Taylor", "given": "Sylvia", "initials": "S"}, {"family": "Bollaerts", "given": "Kaatje", "initials": "K"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "issn-l": null, "volume": "31", "issue": null, "pages": "100675"}, "abstract": "Vaccine effectiveness (VE) studies with long-term follow-up are needed to understand durability of protection against severe COVID-19 outcomes conferred by primary-series vaccination in individuals not receiving boosters. COVIDRIVE is a European public-private partnership evaluating brand-specific vaccine effectiveness (VE). We report a prespecified interim analysis of primary-series AZD1222 (ChAdOx1 nCoV-19) VE.\r\n\r\nSeven Study Contributors in Europe collected data on individuals aged \u226518 years who were hospitalised with severe acute respiratory infection (June 1st, 2021-September 5th, 2022) and eligible for COVID-19 vaccination prior to hospitalisation. In this test-negative case-control study, individuals were defined as test-positive cases or test-negative controls (SARS-CoV-2 RT-PCR) and were either fully vaccinated (two AZD1222 doses, 4-12 weeks apart, completed \u226514 days prior to symptom onset; no booster doses) or unvaccinated (no COVID-19 vaccine prior to hospitalisation). The primary objective was to estimate AZD1222 VE against COVID-19 hospitalisation. A literature review and meta-regression were conducted to contextualise findings on durability of protection.\r\n\r\n761 individuals were included during the 15-month analysis period. Overall AZD1222 VE estimate was 72.8% (95% CI, 53.4-84.1). VE was 93.8% (48.6-99.3) in participants who received second AZD1222 doses \u22648 weeks prior to hospitalisation, with spline-based VE estimates demonstrating protection (VE \u2265 50%) 30 weeks post-second dose. Meta-regression analysis (data from seven publications) showed consistent results, with \u226580% protection against COVID-19 hospitalisation through \u223c43 weeks post-second dose, with some degree of waning.\r\n\r\nPrimary-series AZD1222 vaccination confers protection against COVID-19 hospitalisation with enduring levels of VE through \u22656 months.\r\n\r\nAstraZeneca.", "doi": "10.1016/j.lanepe.2023.100675", "pmid": "37547274", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10398604"}, {"db": "pii", "key": "S2666-7762(23)00094-7"}], "notes": [], "created": "2023-10-05T08:02:31.126Z", "modified": "2023-10-05T08:45:16.573Z"}, {"entity": "publication", "iuid": "6aff3364f8b246b88231e72ccb1373f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6aff3364f8b246b88231e72ccb1373f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6aff3364f8b246b88231e72ccb1373f2"}}, "title": "Professional ethics for infectious disease control: moral conflict management in modern public health practice.", "authors": [{"family": "Timpka", "given": "Toomas", "initials": "T"}, {"family": "Nyce", "given": "James M", "initials": "JM"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Public Health", "issn": "1476-5616", "issn-l": null, "volume": "221", "issue": null, "pages": "160-165"}, "abstract": "Despite scientific evidence that confirms their effectiveness, use of vaccines and microbiological mass testing during the COVID-19 pandemic has been associated with social and moral controversies. In this commentary, it is suggested how such conflicts originating from moral/normative imperatives can be managed in infectious disease control.\r\n\r\nThis was a commentary analysis.\r\n\r\nA case example of scientific and public debate regarding infectious disease control and policy-making during the early pandemic response is first presented. The case is used to characterize how conflicts arising from moral constraints occurred during the COVID-19 pandemic. These features are thereafter used as a basis for outlining a strategy for moral conflict prevention and management.\r\n\r\nA challenge for infectious disease control throughout the pandemic was how to manage persuasive initiatives originating from social forces competing with science for influence. Purposively maneuvered information distributed through social media and internet websites could predispose population factions to contest legitimate (evidence and legally based) pandemic response measures. During the pandemic, fact-based criticism of professionals responsible for infectious disease control was mixed with a critique of their moral standards and intentions so as to diminish effectiveness and credibility. Such blending could be curtailed if infectious disease control professionals are made accountable for public health decisions made in the light of prevalent scientific evidence and legislation.\r\n\r\nIf the infectious disease control community would embrace the international code of medical professional ethics, this would help to deal with moral conflicts, especially ones arising from external threats, in modern public health.", "doi": "10.1016/j.puhe.2023.06.017", "pmid": "37463550", "labels": {"Funder: VR": null, "Category: Health": null, "Category: Public Health": null, "Category: Vaccines": null, "Type: Review": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0033-3506(23)00206-8"}], "notes": [], "created": "2023-10-04T12:09:56.263Z", "modified": "2023-10-04T13:05:52.361Z"}, {"entity": "publication", "iuid": "d73e293cf7c34f7c9502549f02659114", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d73e293cf7c34f7c9502549f02659114.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d73e293cf7c34f7c9502549f02659114"}}, "title": "Prevalence of COVID-19 vaccine acceptance among migrant and refugee groups: A systematic review and meta-analysis.", "authors": [{"family": "Alimoradi", "given": "Zainab", "initials": "Z"}, {"family": "Sallam", "given": "Malik", "initials": "M"}, {"family": "Jafari", "given": "Elahe", "initials": "E"}, {"family": "Potenza", "given": "Marc N", "initials": "MN"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Vaccine X", "issn": "2590-1362", "issn-l": null, "volume": "14", "issue": null, "pages": "100308"}, "abstract": "Understanding COVID-19 vaccine hesitancy among migrant and refugee groups is critical for achieving vaccine equity. Therefore, we aimed to estimate the prevalence of COVID-19 vaccine acceptance among migrant and refugee populations.\r\n\r\nA systematic review (PROSPERO: CRD42022333337) was conducted (December 2019-July 2022) using PubMed, Scopus, Web of Science, ProQuest and Google Scholar.\r\n\r\nNineteen studies from 12 countries were included. The pooled estimated prevalence of COVID-19 vaccine willingness among migrant and refugee groups was 70% (19 studies, 95% CI: 62.3-77.4%, I2: 99.19%, \u03c42: 0.03). Female and male participants did not differ significantly with each other (p = 0.64). Although no individual variable contributed statistically significantly in multivariable meta-regression analysis, the multivariable model that considered methodological quality, mean age of participants, participant group and country of origin explained 67% of variance.\r\n\r\nProportions of migrant/refugee groups receiving COVID-19 vaccinations approximated those observed among general populations. Additional studies are needed to examine factors relating to vaccine willingness to identify the most significant factors that may be targeted in interventions.", "doi": "10.1016/j.jvacx.2023.100308", "pmid": "37223070", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10163798"}, {"db": "pii", "key": "S2590-1362(23)00049-9"}], "notes": [], "created": "2023-10-04T05:10:36.538Z", "modified": "2023-10-04T06:46:36.308Z"}, {"entity": "publication", "iuid": "ccc94b53992b4ba1aed223a6e2656d3e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ccc94b53992b4ba1aed223a6e2656d3e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ccc94b53992b4ba1aed223a6e2656d3e"}}, "title": "Local and Systemic Immunity During Five Vaccinations Against SARS-CoV-2 in Zanubrutinib-Treated Patients With Chronic Lymphocytic Leukemia.", "authors": [{"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Wu", "given": "Jinghua", "initials": "J"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Aberg", "given": "Mikael", "initials": "M"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "Naud", "given": "Sabrina", "initials": "S"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Palma", "given": "Marzia", "initials": "M"}, {"family": "Mellstedt", "given": "Hakan", "initials": "H"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Sallberg Chen", "given": "Margaret", "initials": "M"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Ingelman-Sundberg", "given": "Hanna M", "initials": "HM"}, {"family": "Osterborg", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "J Hematol", "issn": "1927-1220", "issn-l": null, "volume": "12", "issue": "4", "pages": "170-175"}, "abstract": "Patients with chronic lymphocytic leukemia (CLL) are vulnerable to coronavirus disease 2019 (COVID-19) and are at risk of inferior response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination, especially if treated with the first-generation Bruton's tyrosine kinase inhibitor (BTKi) ibrutinib. We aimed to evaluate the impact of the third-generation BTKi, zanubrutinib, on systemic and mucosal response to SARS-CoV-2 vaccination.\r\n\r\nNine patients with CLL with ongoing zanubrutinib therapy were included and donated blood and saliva during SARS-CoV-2 vaccination, before vaccine doses 3 and 5 and 2 - 3 weeks after doses 3, 4, and 5. Ibrutinib-treated control patients (n = 7) and healthy aged-matched controls (n = 7) gave blood 2 - 3 weeks after vaccine dose 5. We quantified reactivity and neutralization capacity of SARS-CoV-2-specific IgG and IgA antibodies (Abs) in both serum and saliva, and reactivity of T cells activated with viral peptides.\r\n\r\nBoth zanubrutinib- and ibrutinib-treated patients had significantly, up to 1,000-fold, lower total spike-specific Ab levels after dose 5 compared to healthy controls (P < 0.01). Spike-IgG levels in serum from zanubrutinib-treated patients correlated well to neutralization capacity (r = 0.68; P < 0.0001) and were thus functional. Mucosal immunity (specific IgA in serum and saliva) was practically absent in zanubrutinib-treated patients even after five vaccine doses, whereas healthy controls had significantly higher levels (tested in serum after vaccine dose 5) (P < 0.05). In contrast, T-cell reactivity against SARS-CoV-2 peptides was equally high in zanubrutinib- and ibrutinib-treated patients as in healthy control donors.\r\n\r\nIn our small cohort of zanubrutinib-treated CLL patients, we conclude that up to five doses of SARS-CoV-2 vaccination induced no detectable IgA mucosal immunity, which likely will impair the primary barrier defence against the infection. Systemic IgG responses were also impaired, whereas T-cell responses were normal. Further and larger studies are needed to evaluate the impact of these findings on disease protection.", "doi": "10.14740/jh1140", "pmid": "37692865", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10482612"}], "notes": [], "created": "2023-10-06T06:52:48.781Z", "modified": "2023-10-06T09:56:27.790Z"}, {"entity": "publication", "iuid": "12974aeee56640e7b04a0fe610c40f4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/12974aeee56640e7b04a0fe610c40f4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/12974aeee56640e7b04a0fe610c40f4c"}}, "title": "Living alone and mental health: parallel analyses in UK longitudinal population surveys and electronic health records prior to and during the COVID-19 pandemic.", "authors": [{"family": "McElroy", "given": "Eoin", "initials": "E", "orcid": "0000-0001-5466-8522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf4d10d067cd401896f2e1d5d5407f41.json"}}, {"family": "Herrett", "given": "Emily", "initials": "E", "orcid": "0000-0002-9425-644X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff5906d75a654724bba356031a4394e8.json"}}, {"family": "Patel", "given": "Kishan", "initials": "K", "orcid": "0000-0002-5693-6831", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4edb8e82fdf4c60874bad3eb9ceb6bc.json"}}, {"family": "Piehlmaier", "given": "Dominik M", "initials": "DM", "orcid": "0000-0003-0229-7007", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3957625c2ee04099a46f9b34334516d9.json"}}, {"family": "Gessa", "given": "Giorgio Di", "initials": "GD", "orcid": "0000-0001-6154-1845", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c2319c222cc40069a5f55ead6d361f6.json"}}, {"family": "Huggins", "given": "Charlotte", "initials": "C", "orcid": "0000-0001-5960-4771", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a02a696d498246b78636287e668394c8.json"}}, {"family": "Green", "given": "Michael J", "initials": "MJ", "orcid": "0000-0003-3193-2452", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84efba4af3264153b510906d0f4dcb35.json"}}, {"family": "Kwong", "given": "Alex S F", "initials": "ASF", "orcid": "0000-0003-1953-2771", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65ccb94351224dbdbcaa53d6ef6502ba.json"}}, {"family": "Thompson", "given": "Ellen J", "initials": "EJ", "orcid": "0000-0003-2118-821X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6754739394b24a5c8f5db22905b22c3c.json"}}, {"family": "Zhu", "given": "Jingmin", "initials": "J", "orcid": "0000-0001-8325-7589", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2ea57fd9f164a4687613cc7692ec378.json"}}, {"family": "Mansfield", "given": "Kathryn E", "initials": "KE"}, {"family": "Silverwood", "given": "Richard J", "initials": "RJ", "orcid": "0000-0002-2744-1194", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d46ad9468444d3dbfbe8f392b9fb502.json"}}, {"family": "Mansfield", "given": "Rosie", "initials": "R"}, {"family": "Maddock", "given": "Jane", "initials": "J", "orcid": "0000-0002-7975-4221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96323411c0b4423bb94776fea40f3f79.json"}}, {"family": "Mathur", "given": "Rohini", "initials": "R", "orcid": "0000-0002-3817-8790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/413a53b2b6734b6983ce583bf8ae9849.json"}}, {"family": "Costello", "given": "Ruth E", "initials": "RE", "orcid": "0000-0003-2709-6666", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c0fe69f61b54ab89f9a3de852f872a8.json"}}, {"family": "Matthews", "given": "Anthony", "initials": "A"}, {"family": "Tazare", "given": "John", "initials": "J", "orcid": "0000-0002-7194-2615", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/edd71baff18241099ed99c9770b9aad6.json"}}, {"family": "Henderson", "given": "Alasdair", "initials": "A", "orcid": "0000-0002-8903-4906", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/136c2cef770547d9a777c334746755a7.json"}}, {"family": "Wing", "given": "Kevin", "initials": "K", "orcid": "0000-0003-2335-9641", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a5697cdb0ed469091230d744f22a31c.json"}}, {"family": "Bridges", "given": "Lucy", "initials": "L", "orcid": "0000-0002-4407-9596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07faf17819de4a219027db6f265bad97.json"}}, {"family": "Bacon", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-6354-3454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6616a304a007470e8fce5b54c5874156.json"}}, {"family": "Mehrkar", "given": "Amir", "initials": "A", "orcid": "0000-0002-2098-1278", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee1d683bf7114dc8a4deace10b1cd4ce.json"}}, {"family": "OpenSAFELY Collaborative", "given": "", "initials": ""}, {"family": "Shaw", "given": "Richard John", "initials": "RJ", "orcid": "0000-0002-7906-6066", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e70bea99a7b44fbeaa9841571db846a3.json"}}, {"family": "Wels", "given": "Jacques", "initials": "J", "orcid": "0000-0002-9292-917X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03eb758b02f04c3583536497f996ea68.json"}}, {"family": "Katikireddi", "given": "Srinivasa Vittal", "initials": "SV", "orcid": "0000-0001-6593-9092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9bcdfb6c28e742878e7df8ee66fa6863.json"}}, {"family": "Chaturvedi", "given": "Nish", "initials": "N", "orcid": "0000-0002-6211-2775", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94889a94593342f688fc89e9419ef7d0.json"}}, {"family": "Tomlinson", "given": "Laurie A", "initials": "LA", "orcid": "0000-0001-8848-9493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03f2034f701e46f3919a944d2ac325d7.json"}}, {"family": "Patalay", "given": "Praveetha", "initials": "P", "orcid": "0000-0002-5341-3461", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c768af96078f4a0f9dc121d07bef6f81.json"}}, {"family": "Longitudinal Health and Wellbeing Collaborative", "given": "", "initials": ""}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "BMJ Ment Health", "issn": "2755-9734", "issn-l": null, "volume": "26", "issue": "1", "pages": null}, "abstract": "People who live alone experience greater levels of mental illness; however, it is unclear whether the COVID-19 pandemic had a disproportionately negative impact on this demographic.\r\n\r\nTo describe the mental health gap between those who live alone and with others in the UK prior to and during the COVID-19 pandemic.\r\n\r\nSelf-reported psychological distress and life satisfaction in 10 prospective longitudinal population surveys (LPSs) assessed in the nearest pre-pandemic sweep and three periods during the pandemic. Recorded diagnosis of common and severe mental illnesses between March 2018 and January 2022 in electronic healthcare records (EHRs) within the OpenSAFELY-TPP.\r\n\r\nIn 37 544 LPS participants, pooled models showed greater psychological distress (standardised mean difference (SMD): 0.09 (95% CI: 0.04; 0.14); relative risk: 1.25 (95% CI: 1.12; 1.39)) and lower life satisfaction (SMD: -0.22 (95% CI: -0.30; -0.15)) for those living alone pre-pandemic. This gap did not change during the pandemic. In the EHR analysis of c.16 million records, mental health conditions were more common in those who lived alone (eg, depression 26 (95% CI: 18 to 33) and severe mental illness 58 (95% CI: 54 to 62) more cases more per 100 000). For common mental health disorders, the gap in recorded cases in EHRs narrowed during the pandemic.\r\n\r\nPeople living alone have poorer mental health and lower life satisfaction. During the pandemic, this gap in self-reported distress remained; however, there was a narrowing of the gap in service use.\r\n\r\nGreater mental health need and potentially greater barriers to mental healthcare access for those who live alone need to be considered in healthcare planning.", "doi": "10.1136/bmjment-2023-300842", "pmid": "37562853", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pii", "key": "bmjment-2023-300842"}], "notes": [], "created": "2023-10-05T08:26:51.207Z", "modified": "2023-10-06T05:16:12.883Z"}, {"entity": "publication", "iuid": "fa914e711dd04aa88bad9970b0bea1f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa914e711dd04aa88bad9970b0bea1f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa914e711dd04aa88bad9970b0bea1f0"}}, "title": "Impact of asthma in Europe: A comparison of web search data in 21 European countries.", "authors": [{"family": "Wecker", "given": "Hannah", "initials": "H"}, {"family": "Tizek", "given": "Linda", "initials": "L"}, {"family": "Ziehfreund", "given": "Stefanie", "initials": "S"}, {"family": "Kain", "given": "Alphina", "initials": "A"}, {"family": "Traidl-Hoffmann", "given": "Claudia", "initials": "C"}, {"family": "Zimmermann", "given": "Gregor S", "initials": "GS"}, {"family": "Scala", "given": "Emanuele", "initials": "E"}, {"family": "Elberling", "given": "Jesper", "initials": "J"}, {"family": "Doll", "given": "Ana\u00efs", "initials": "A"}, {"family": "Boffa", "given": "Michael J", "initials": "MJ"}, {"family": "Schmidt", "given": "Lea", "initials": "L"}, {"family": "Sikora", "given": "Mariusz", "initials": "M"}, {"family": "Torres", "given": "Tiago", "initials": "T"}, {"family": "Ballardini", "given": "Natalia", "initials": "N"}, {"family": "Chernyshov", "given": "Pavel V", "initials": "PV"}, {"family": "Buters", "given": "Jeroen", "initials": "J"}, {"family": "Biedermann", "given": "Tilo", "initials": "T"}, {"family": "Zink", "given": "Alexander", "initials": "A"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "World Allergy Organ J", "issn": "1939-4551", "issn-l": "1939-4551", "volume": "16", "issue": "8", "pages": "100805"}, "abstract": "Asthma is a chronic inflammatory disorder of the airways and one of the most important non-communicable diseases worldwide. Analyzing crowdsourced data can help understand public interest and unmet needs as well as potential factors influencing search behavior.\r\n\r\nThe study aimed to investigate asthma-related web search data in Europe to identify possible regional and seasonal variations and to assess public interest.\r\n\r\nGoogle Ads Keyword Planner was used to measure search volume for search terms related to asthma, allergic asthma, and bronchial asthma in 21 European countries between January 2018 and December 2021. The top 10 keywords of each country were categorized qualitatively. Search volume per 100 000 inhabitants was descriptively assessed in terms of regional and seasonal trends. Spearman correlations between search volume and pollen concentration as well as coronavirus disease (COVID-19) cases were investigated.\r\n\r\nThe median search volume per 100 000 inhabitants for asthma and allergic asthma was highest in Northern and Western Europe, while the highest search volume for bronchial asthma was observed in Western and Eastern regions. A seasonal trend was identified for all search terms and in all regions. Correlations were found between search frequency and pollen load and search behavior and COVID-19 cases. Overall, Europeans were most interested in the diseases in general, their treatment options, and symptoms.\r\n\r\nThese results highlighted the need for reliable and region-specific information about the disease and for public campaigns to improve asthma control. The study also emphasizes the importance of using crowdsourced data for a more encompassing overview beyond conventional healthcare data.", "doi": "10.1016/j.waojou.2023.100805", "pmid": "37564904", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10410582"}, {"db": "pii", "key": "S1939-4551(23)00065-0"}], "notes": [], "created": "2023-10-05T08:26:40.891Z", "modified": "2023-10-06T05:03:14.211Z"}, {"entity": "publication", "iuid": "b0d93f664e8e4e268d06ed0166907d8a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b0d93f664e8e4e268d06ed0166907d8a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b0d93f664e8e4e268d06ed0166907d8a"}}, "title": "High Exposure to Perfluoroalkyl Substances and Antibody Responses to SARS-CoV-2 mRNA Vaccine-an Observational Study in Adults from Ronneby, Sweden.", "authors": [{"family": "Andersson", "given": "Axel G", "initials": "AG", "orcid": "0000-0002-1215-8433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/291ed3a52d1c470fad6855915a959b69.json"}}, {"family": "Lundgren", "given": "Anna", "initials": "A"}, {"family": "Xu", "given": "Yiyi", "initials": "Y"}, {"family": "Nielsen", "given": "Christel", "initials": "C"}, {"family": "Lindh", "given": "Christian H", "initials": "CH"}, {"family": "Pineda", "given": "Daniela", "initials": "D"}, {"family": "Cederlund", "given": "Julia", "initials": "J"}, {"family": "Pataridou", "given": "Elisavet", "initials": "E"}, {"family": "S\u00f8gaard T\u00f8ttenborg", "given": "Sandra", "initials": "S"}, {"family": "Ugelvig Petersen", "given": "Kajsa", "initials": "K"}, {"family": "Fletcher", "given": "Tony", "initials": "T"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Bemark", "given": "Mats", "initials": "M"}, {"family": "Jakobsson", "given": "Kristina", "initials": "K"}, {"family": "Li", "given": "Ying", "initials": "Y"}], "type": "observational study", "published": "2023-08-00", "journal": {"title": "Environ Health Perspect", "issn": "1552-9924", "issn-l": null, "volume": "131", "issue": "8", "pages": "87007"}, "abstract": "Per- and polyfluoroalkyl substances (PFAS) are widely used, environmentally ubiquitous, and stable chemicals that have been associated with lower vaccine-induced antibody responses in children; however, data on adults are limited. The drinking water from one of the two waterworks in Ronneby, Sweden, was heavily contaminated for decades with PFAS from firefighting foams, primarily perfluorohexane sulfonic acid and perfluorooctanesulfonic acid (PFOS). Vaccination against SARS-CoV-2 offered a unique opportunity to investigate antibody responses to primary vaccination in adults who had been exposed to PFAS.\r\n\r\nOur objective was to evaluate associations between PFAS, across a wide range of exposure levels, and antibody responses in adults 5 wk and 6 months after a two-dose vaccination regime against SARS-CoV-2.\r\n\r\nAdults age 20-60 y from Ronneby (, median PFOS serum level n=309, fifth to 95th percentile 47 ng/mL) and a group with background exposure (4-213 ng/mL, median PFOS serum level n=47) received two doses of the Spikevax (Moderna) mRNA vaccine. The levels of seven PFAS were measured in serum before vaccination. Serum immunoglobulin G antibodies against the SARS-CoV-2 spike antigen (S-Abs) were measured before vaccination and at 5 wk (4 ng/mL) and 6 months (n=350) after the second vaccine dose. Linear regression analyses were fitted against current, historical, and prenatal exposure to PFAS, adjusting for sex, age, and smoking, excluding individuals with previous SARS-CoV-2-infection.n=329\r\n\r\nPFAS exposure, regardless of how it was estimated, was not negatively associated with antibody levels 5 wk [current PFOS: S-Abs/PFOS interquartile range (IQR); 95% confidence interval (CI): -0.5%, 7] or 6 months (current PFOS: 3% S-Abs/PFOS IQR; 95% CI: -8, 12) after COVID-19 vaccination.-6\r\n\r\nFollowing a strict study protocol, rigorous study design, and few dropouts, we found no indication that PFAS exposure negatively affected antibody responses to COVID-19 mRNA vaccination for up to 6 months after vaccination. https://doi.org/10.1289/EHP11847.", "doi": "10.1289/EHP11847", "pmid": "37578904", "labels": {"Funder: Forte": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10424820"}, {"db": "EudraCT", "key": "2021-000842-16"}], "notes": [], "created": "2023-10-05T08:01:59.033Z", "modified": "2023-10-05T08:40:06.917Z"}, {"entity": "publication", "iuid": "5428e4b796a945bcafd9aee56df86839", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5428e4b796a945bcafd9aee56df86839.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5428e4b796a945bcafd9aee56df86839"}}, "title": "Food-related experiences and behavioral responses among people affected by chemosensory dysfunctions following COVID-19: A scoping review.", "authors": [{"family": "Neuman", "given": "Nicklas", "initials": "N", "orcid": "0000-0001-7970-4753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d135c1772d041e1af59c646a97ca9a0.json"}}, {"family": "Sandvik", "given": "Pernilla", "initials": "P"}, {"family": "Lindholm", "given": "Ninni Bellini", "initials": "NB"}, {"family": "B\u00f6mer-Schulte", "given": "Katharina", "initials": "K"}, {"family": "L\u00f6vestam", "given": "Elin", "initials": "E"}], "type": "review", "published": "2023-08-00", "journal": {"title": "Res Nurs Health", "issn": "1098-240X", "issn-l": null, "volume": "46", "issue": "4", "pages": "385-399"}, "abstract": "A category of symptoms that became characteristic early in the first wave of the coronavirus disease 2019 (COVID-19) pandemic was chemosensory dysfunctions (alterations of smell and taste). Such symptoms substantially affect food and eating-cornerstones for both nutrition-related health outcomes and for quality of life. Based on this, this scoping review aimed to map out existing scientific literature on food-related experiences and related behavioral responses among people affected by chemosensory dysfunctions following COVID-19. A librarian-supported search of PsycInfo, PubMed, and Scopus for publications written in English (2020 to April 26, 2022) was conducted. Two authors searched for and screened publications and three others extracted and collated data. These are reported following the Preferred Reporting Items of Systematic reviews and Meta-Analyses extension for Scoping Reviews. Of 1169 hits, 9 publications were included in the review. The results are thematized as \"Psychological and social aspects\" and \"Nutritional aspects,\" each with the subsections \"Experiences\" and \"Behavioral responses.\" A great variety of food-related problems, nutritional and mental health effects, and implications for social life are identified. People affected by chemosensory dysfunctions following COVID-19 suffer, as evident both in stories from qualitative studies and in measurements of quality of life. The results impact all professions who are and may come to be involved in treating these patients, such as nurses, physicians, dietitians, and psychologists. With more knowledge about the dysfunctions' manifestation, duration, and impact on everyday life, multiprofessional teams need to collaborate in supporting patients medically, psychosocially, and nutritionally.", "doi": "10.1002/nur.22315", "pmid": "37171788", "labels": {"Category: Health": null, "Type: Review": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:10:50.604Z", "modified": "2023-10-04T07:00:13.599Z"}, {"entity": "publication", "iuid": "4958e8848a3946d2be85f7443d18d7cd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4958e8848a3946d2be85f7443d18d7cd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4958e8848a3946d2be85f7443d18d7cd"}}, "title": "Effect of external dead space removal on CO2 homeostasis in mechanically ventilated adult Covid-19 patients.", "authors": [{"family": "\u00d6hman", "given": "Tomas", "initials": "T"}, {"family": "Jalde", "given": "Francesca Campoccia", "initials": "FC"}, {"family": "Fredby", "given": "Magnus", "initials": "M"}, {"family": "Bj\u00f6rne", "given": "H\u00e5kan", "initials": "H"}, {"family": "Karlsson", "given": "Jacob", "initials": "J", "orcid": "0000-0003-2277-0092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a428771f0dc41948d1d1e13131497bc.json"}}], "type": "observational study", "published": "2023-08-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": "67", "issue": "7", "pages": "936-942"}, "abstract": "Patients with Covid-19 respiratory failure present with hypoxemia, often in combination with hypercapnia. In this prospective, observational study we examined the effect of removing external dead space (DS) on CO2 -homeostasis in mechanically ventilated Covid-19 patients. In addition, volumetric capnography was validated for its ability to estimate external DS volume using in vitro measured DS volumes as reference.\r\n\r\nIn total, 10 patients with acute respiratory distress syndrome from Covid-19 were included. Volumetric capnography, mechanical ventilation, and arterial blood gas data were analyzed before and after removal of external DS and analyzed for potentially significant changes in response to DS removal. Measurements of external DS were obtained in circuit using volumetric capnography and compared to actual measured DS volumes off the circuit.\r\n\r\nAfter the removal of external DS, the alveolar minute ventilation and CO2 elimination improved, notwithstanding unchanged respiratory rate and tidal volumes. The increase in CO2 elimination was associated with a decrease in arterial CO2 partial pressure (PaCO2 ). The volumetric capnography method for assessment of external DS showed a low bias of -9 mL (lower limit of agreement -40, 95% CI -60 to -20 mL, upper limit of agreement 21 mL, 95% CI: 1-40 mL) and a percentage error of 48% compared to absolute values measured in vitro.\r\n\r\nRemoval of external DS increased alveolar minute ventilation and CO2 elimination in Covid-19 patients with respiratory failure in the current study. This was associated with a decrease in PaCO2 . This may indicate a decreased CO2 production due to decreased work of breathing and more effective gas-exchange in response to DS removal. In addition, volumetric capnography appears to be a clinically feasible method for continuous measurement of external DS in the current study and may be of value in optimizing ventilator treatment.", "doi": "10.1111/aas.14252", "pmid": "37354078", "labels": {"Category: Health": null, "Funder: Vinnova": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:31:09.191Z", "modified": "2023-10-04T10:44:03.243Z"}, {"entity": "publication", "iuid": "54c4d494ea0b4df8bacb49481ba454ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54c4d494ea0b4df8bacb49481ba454ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54c4d494ea0b4df8bacb49481ba454ff"}}, "title": "Echocardiography phenotypes of right ventricular involvement in COVID-19 ARDS patients and ICU mortality: post-hoc (exploratory) analysis of repeated data from the ECHO-COVID study.", "authors": [{"family": "Huang", "given": "Stephen", "initials": "S"}, {"family": "Vieillard-Baron", "given": "Antoine", "initials": "A"}, {"family": "Evrard", "given": "Bruno", "initials": "B", "orcid": "0000-0003-1829-4927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bba6533429b5415ab89299eda9c64d57.json"}}, {"family": "Prat", "given": "Gwena\u00ebl", "initials": "G"}, {"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Balik", "given": "Martin", "initials": "M"}, {"family": "Clau-Terr\u00e9", "given": "Fernando", "initials": "F"}, {"family": "De Backer", "given": "Daniel", "initials": "D"}, {"family": "Mekontso Dessap", "given": "Armand", "initials": "A"}, {"family": "Orde", "given": "Sam", "initials": "S"}, {"family": "Morelli", "given": "Andrea", "initials": "A"}, {"family": "Sanfilippo", "given": "Filippo", "initials": "F"}, {"family": "Charron", "given": "Cyril", "initials": "C"}, {"family": "Vignon", "given": "Philippe", "initials": "P", "orcid": "0000-0003-4551-5772", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9944b30a58047218e6e4cf59c3572b4.json"}}, {"family": "ECHO-COVID study group", "given": "", "initials": ""}], "type": "observational study", "published": "2023-08-00", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "issn-l": "0342-4642", "volume": "49", "issue": "8", "pages": "946-956"}, "abstract": "Exploratory study to evaluate the association of different phenotypes of right ventricular (RV) involvement and mortality in the intensive care unit (ICU) in patients with acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19).\r\n\r\nPost-hoc analysis of longitudinal data from the multicenter ECHO-COVID observational study in ICU patients who underwent at least two echocardiography examinations. Echocardiography phenotypes were acute cor pulmonale (ACP, RV cavity dilatation with paradoxical septal motion), RV failure (RVF, RV cavity dilatation and systemic venous congestion), and RV dysfunction (tricuspid annular plane systolic excursion \u2264 16 mm). Accelerated failure time model and multistate model were used for analysis.\r\n\r\nOf 281 patients who underwent 948 echocardiography studies during ICU stay, 189 (67%) were found to have at least 1 type of RV involvements during one or several examinations: ACP (105/281, 37.4%), RVF (140/256, 54.7%) and/or RV dysfunction (74/255, 29%). Patients with all examinations displaying ACP had survival time shortened by 0.479 [0.284-0.803] times when compared to patients with all examinations depicting no ACP (P = 0.005). RVF showed a trend towards shortened survival time by a factor of 0.642 [0.405-1.018] (P = 0.059), whereas the impact of RV dysfunction on survival time was inconclusive (P = 0.451). Multistate analysis showed that patients might transit in and out of RV involvement, and those who exhibited ACP in their last critical care echocardiography (CCE) examination had the highest risk of mortality (hazard ratio (HR) 3.25 [2.38-4.45], P < 0.001).\r\n\r\nRV involvement is prevalent in patients ventilated for COVID-19 ARDS. Different phenotypes of RV involvement might lead to different ICU mortality, with ACP having the worst outcome.", "doi": "10.1007/s00134-023-07147-z", "pmid": "37436445", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-023-07147-z"}, {"db": "ClinicalTrials.gov", "key": "NCT04414410"}], "notes": [], "created": "2023-10-04T12:10:45.208Z", "modified": "2023-10-04T13:30:45.479Z"}, {"entity": "publication", "iuid": "78855cf5737a471daf4bde2997a75b88", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/78855cf5737a471daf4bde2997a75b88.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/78855cf5737a471daf4bde2997a75b88"}}, "title": "Concordance between COVID-19 mortality statistics derived from clinical audit and death certificates in \u00d6sterg\u00f6tland county, Sweden.", "authors": [{"family": "Spreco", "given": "A", "initials": "A"}, {"family": "Andersson", "given": "C", "initials": "C"}, {"family": "Sj\u00f6dahl", "given": "R", "initials": "R"}, {"family": "Timpka", "given": "T", "initials": "T"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Public Health", "issn": "1476-5616", "issn-l": null, "volume": "221", "issue": null, "pages": "46-49"}, "abstract": "Despite early notions that correct attribution of deaths caused by SARS-CoV-2 infection is critical to the understanding of the COVID-19 pandemic, three years later, the accuracy of COVID-19 death counts is still contested. We aimed to compare official death statistics with cause-of-death assessments made in a clinical audit routine by experienced physicians having access to the full medical record.\r\n\r\nHealth service quality evaluation.\r\n\r\nIn \u00d6sterg\u00f6tland county (pop. 465,000), Sweden, a clinical audit team assessed from the start of the pandemic the cause of death in individuals having deceased after testing positive for SARS-CoV-2. We estimated the concordance between official data on COVID-19 deaths and data from the clinical audit using correlations (r) between the cause-of-death categories and discrepancies between the absolute numbers of categorised deaths.\r\n\r\nThe concordance between the data sources was poor regarding whether COVID-19 was the underlying or a contributing cause of death. Grouping of the causes increased the correlations to acceptable strength. Also including deaths implicated by a positive SARS-CoV-2 test in the clinical categorisation of COVID-19 deaths reduced the difference in absolute number of deaths; with these modifications, the concordance was acceptable before the COVID-19 vaccination program was initiated (r = 0.97; symmetric mean absolute percentage error (SMAPE) = 19%), while a difference in the absolute numbers of deaths remained in the vaccination period (r = 0.94; SMAPE = 35%).\r\n\r\nThis study highlights that carefulness is warranted when COVID-19 death statistics are used in health service planning and resonates a need for further research on cause-of-death recording methodologies.", "doi": "10.1016/j.puhe.2023.06.007", "pmid": "37399611", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10250145"}, {"db": "pii", "key": "S0033-3506(23)00196-8"}], "notes": [], "created": "2023-10-04T12:07:35.390Z", "modified": "2023-10-04T12:20:18.768Z"}, {"entity": "publication", "iuid": "03df4cb9fa074a96b65ad775b99372a7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/03df4cb9fa074a96b65ad775b99372a7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/03df4cb9fa074a96b65ad775b99372a7"}}, "title": "Collaborative nowcasting of COVID-19 hospitalization incidences in Germany.", "authors": [{"family": "Wolffram", "given": "Daniel", "initials": "D", "orcid": "0000-0003-0318-3669", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce85bc05765a499db19a3df6ec4c142b.json"}}, {"family": "Abbott", "given": "Sam", "initials": "S"}, {"family": "An der Heiden", "given": "Matthias", "initials": "M"}, {"family": "Funk", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-2842-3406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f03dcbc41884648a4eac5892852899a.json"}}, {"family": "G\u00fcnther", "given": "Felix", "initials": "F"}, {"family": "Hailer", "given": "Davide", "initials": "D"}, {"family": "Heyder", "given": "Stefan", "initials": "S"}, {"family": "Hotz", "given": "Thomas", "initials": "T"}, {"family": "van de Kassteele", "given": "Jan", "initials": "J"}, {"family": "K\u00fcchenhoff", "given": "Helmut", "initials": "H"}, {"family": "M\u00fcller-Hansen", "given": "S\u00f6ren", "initials": "S"}, {"family": "Syliqi", "given": "Diell\u00eb", "initials": "D"}, {"family": "Ullrich", "given": "Alexander", "initials": "A"}, {"family": "Weigert", "given": "Maximilian", "initials": "M", "orcid": "0000-0003-4400-134X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4022b7edbd404fa695f562f9fd78a051.json"}}, {"family": "Schienle", "given": "Melanie", "initials": "M"}, {"family": "Bracher", "given": "Johannes", "initials": "J", "orcid": "0000-0002-3777-1410", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/edf3423decee40a8835ae6475a141386.json"}}], "type": "case reports", "published": "2023-08-00", "journal": {"title": "PLoS Comput Biol", "issn": "1553-7358", "issn-l": null, "volume": "19", "issue": "8", "pages": "e1011394"}, "abstract": "Real-time surveillance is a crucial element in the response to infectious disease outbreaks. However, the interpretation of incidence data is often hampered by delays occurring at various stages of data gathering and reporting. As a result, recent values are biased downward, which obscures current trends. Statistical nowcasting techniques can be employed to correct these biases, allowing for accurate characterization of recent developments and thus enhancing situational awareness. In this paper, we present a preregistered real-time assessment of eight nowcasting approaches, applied by independent research teams to German 7-day hospitalization incidences during the COVID-19 pandemic. This indicator played an important role in the management of the outbreak in Germany and was linked to levels of non-pharmaceutical interventions via certain thresholds. Due to its definition, in which hospitalization counts are aggregated by the date of case report rather than admission, German hospitalization incidences are particularly affected by delays and can take several weeks or months to fully stabilize. For this study, all methods were applied from 22 November 2021 to 29 April 2022, with probabilistic nowcasts produced each day for the current and 28 preceding days. Nowcasts at the national, state, and age-group levels were collected in the form of quantiles in a public repository and displayed in a dashboard. Moreover, a mean and a median ensemble nowcast were generated. We find that overall, the compared methods were able to remove a large part of the biases introduced by delays. Most participating teams underestimated the importance of very long delays, though, resulting in nowcasts with a slight downward bias. The accompanying prediction intervals were also too narrow for almost all methods. Averaged over all nowcast horizons, the best performance was achieved by a model using case incidences as a covariate and taking into account longer delays than the other approaches. For the most recent days, which are often considered the most relevant in practice, a mean ensemble of the submitted nowcasts performed best. We conclude by providing some lessons learned on the definition of nowcasting targets and practical challenges.", "doi": "10.1371/journal.pcbi.1011394", "pmid": "37566642", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Other": null, "Funder: NordForsk": null}, "xrefs": [{"db": "pmc", "key": "PMC10446237"}, {"db": "pii", "key": "PCOMPBIOL-D-23-00600"}], "notes": [], "created": "2023-10-05T08:27:07.259Z", "modified": "2023-10-06T05:21:23.352Z"}, {"entity": "publication", "iuid": "280a86d0e27f4240af16b8cfe3cffbab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/280a86d0e27f4240af16b8cfe3cffbab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/280a86d0e27f4240af16b8cfe3cffbab"}}, "title": "Classification of \"Near-patient\" and \"Point-of-Care\" SARS-CoV-2 Nucleic Acid Amplification Test Systems and a first approach to evaluate their analytical independence of operator activities.", "authors": [{"family": "Buchta", "given": "Christoph", "initials": "C"}, {"family": "Zeichhardt", "given": "Heinz", "initials": "H"}, {"family": "Badrick", "given": "Tony", "initials": "T"}, {"family": "Coucke", "given": "Wim", "initials": "W"}, {"family": "Wojtalewicz", "given": "Nathalie", "initials": "N"}, {"family": "Griesmacher", "given": "Andrea", "initials": "A"}, {"family": "Aberle", "given": "Stephan W", "initials": "SW"}, {"family": "Schellenberg", "given": "Ingo", "initials": "I"}, {"family": "Jacobs", "given": "Ellis", "initials": "E"}, {"family": "Nordin", "given": "Gunnar", "initials": "G"}, {"family": "Schweiger", "given": "Christian", "initials": "C"}, {"family": "Schwenoha", "given": "Karin", "initials": "K"}, {"family": "Luppa", "given": "Peter B", "initials": "PB"}, {"family": "Gassner", "given": "Ulrich M", "initials": "UM"}, {"family": "Wagner", "given": "Thomas", "initials": "T"}, {"family": "Kammel", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "J Clin Virol", "issn": "1873-5967", "issn-l": null, "volume": "165", "issue": null, "pages": "105521"}, "abstract": "European legislation defines as \"near-patient testing\" (NPT) what is popularly and in other legislations specified as \"point-of-care testing\" (POCT). Systems intended for NPT/POCT use must be characterized by independence from operator activities during the analytic procedure. However, tools for evaluating this are lacking. We hypothesized that the variability of measurement results obtained from identical samples with a larger number of identical devices by different operators, expressed as the method-specific reproducibility of measurement results reported in External Quality Assessment (EQA) schemes, is an indicator for this characteristic.\r\n\r\nLegal frameworks in the EU, the USA and Australia were evaluated about their requirements for NPT/POCT. EQA reproducibility of seven SARS-CoV-2-NAAT systems, all but one designated as \"POCT\", was calculated from variabilities in Ct values obtained from the respective device types in three different EQA schemes for virus genome detection.\r\n\r\nA matrix for characterizing test systems based on their technical complexity and the required operator competence was derived from requirements of the European In Vitro Diagnostic Regulation (IVDR) 2017/746. Good EQA reproducibility of the measurement results of the test systems investigated implies that different users in different locations have no recognizable influence on their measurement results.\r\n\r\nThe fundamental suitability of test systems for NPT/POCT use according to IVDR can be easily verified using the evaluation matrix presented. EQA reproducibility is a specific characteristic indicating independence from operator activities of NPT/POCT assays. EQA reproducibility of other systems than those investigated here remains to be determined.", "doi": "10.1016/j.jcv.2023.105521", "pmid": "37302248", "labels": {"Category: Health": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10249340"}, {"db": "pii", "key": "S1386-6532(23)00144-0"}], "notes": [], "created": "2023-10-04T09:33:21.018Z", "modified": "2023-10-04T11:24:26.997Z"}, {"entity": "publication", "iuid": "fe5a3c1f5a5b4f54978442d6e30d165e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fe5a3c1f5a5b4f54978442d6e30d165e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fe5a3c1f5a5b4f54978442d6e30d165e"}}, "title": "Certified Registered Nurse Anesthetists' Experience of Relocation to COVID-19 Intensive Care-A Qualitative Interview Study.", "authors": [{"family": "Sundblad", "given": "Hanna", "initials": "H"}, {"family": "Hommel", "given": "Ami", "initials": "A"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "AANA J", "issn": "2162-5239", "issn-l": null, "volume": "91", "issue": "4", "pages": "273-278"}, "abstract": "In spring 2020, a global SARS-Cov-2 pandemic was declared. The number of patients in need of intensive care exceeded the number of available care places at intensive care units (ICUs) and certified registered nurse anesthetists (CRNAs) were relocated to ICUs to support the care during the pandemic. The aim of this study was to illuminate the experiences of the CRNAs regarding relocation to COVID-19 intensive care. An interview study based on qualitative content analysis was conducted. The participants were CRNAs who usually work in the operating unit, however, were relocated to work in the COVID-19 ICU at a university hospital in southern Sweden during the pandemic. Four themes emerge in the results: sense of pride, competence, work environment, and nursing. The results illuminate the CRNAs' experience of relocating from their usual working environment to caring for critically ill patients in a COVID-19 ICU. The CRNAs managed the relocation well, although sometimes it was difficult. The CRNAs showed great loyalty, dedication, competence, and flexibility in their professional capacity. The time they worked in COVID-19 intensive care was a challenging period, but it gave them a well-deserved sense of pride and competence.", "doi": null, "pmid": "37527166", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:01:43.210Z", "modified": "2023-10-05T08:33:29.679Z"}, {"entity": "publication", "iuid": "a6f1f97a78a040648dfc986fcc4278c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6f1f97a78a040648dfc986fcc4278c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6f1f97a78a040648dfc986fcc4278c0"}}, "title": "The impact of hybrid immunity on immune responses after SARS-CoV-2 vaccination in persons with multiple sclerosis treated with disease-modifying therapies.", "authors": [{"family": "Rabenstein", "given": "Monika", "initials": "M"}, {"family": "Thomas", "given": "Olivia G", "initials": "OG"}, {"family": "Carlin", "given": "Giorgia", "initials": "G"}, {"family": "Khademi", "given": "Mohsen", "initials": "M"}, {"family": "H\u00f6gelin", "given": "Klara Asplund", "initials": "KA", "orcid": "0000-0002-3696-355X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e30a564a8ac14f97af8d46d222dff3ab.json"}}, {"family": "Malmestr\u00f6m", "given": "Clas", "initials": "C"}, {"family": "Axelsson", "given": "Markus", "initials": "M"}, {"family": "Brandt", "given": "Anne Frandsen", "initials": "AF"}, {"family": "Gafvelin", "given": "Guro", "initials": "G"}, {"family": "Gr\u00f6nlund", "given": "Hans", "initials": "H"}, {"family": "Kockum", "given": "Ingrid", "initials": "I"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Lycke", "given": "Jan", "initials": "J"}, {"family": "Olsson", "given": "Tomas", "initials": "T"}, {"family": "Hessa", "given": "Tara", "initials": "T"}], "type": "journal article", "published": "2023-07-31", "journal": {"title": "Eur J Neurol", "issn": "1468-1331", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Hybrid immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develops from a combination of natural infection and vaccine-generated immunity. Multiple sclerosis (MS) disease-modifying therapies (DMTs) have the potential to impact humoral and cellular immunity induced by SARS-CoV-2 vaccination and infection. The aims were to compare antibody and T-cell responses after SARS-CoV-2 mRNA vaccination in persons with MS (pwMS) treated with different DMTs and to assess differences between na\u00efvely vaccinated pwMS and pwMS with hybrid immunity vaccinated following a previous SARS-CoV-2 infection.\r\n\r\nAntibody and T-cell responses were determined in pwMS at baseline and 4 and 12 weeks after the second dose of SARS-CoV-2 vaccination in 143 pwMS with or without previous SARS-CoV-2 infection and 40 healthy controls (HCs). The MS cohort comprised natalizumab (n = 22), dimethylfumarate (n = 23), fingolimod (n = 38), cladribine (n = 30), alemtuzumab (n = 17) and teriflunomide (n = 13) treated pwMS. Immunoglobulin G antibody responses to SARS-CoV-2 antigens were measured using a multiplex bead assay and FluoroSpot was used to assess T-cell responses (interferon \u03b3 and interleukin 13).\r\n\r\nHumoral and T-cell responses to vaccination were comparable between na\u00efvely vaccinated HCs and pwMS treated with natalizumab, dimethylfumarate, cladribine, alemtuzumab and teriflunomide, but were suppressed in fingolimod-treated pwMS. Both fingolimod-treated pwMS and HCs vaccinated following a previous SARS-CoV-2 infection had higher antibody levels 4 weeks after vaccination compared to na\u00efvely vaccinated individuals. Antibody and interferon \u03b3 levels 12 weeks after vaccination were positively correlated with time from last treatment course of cladribine.\r\n\r\nThese findings are of relevance for infection risk mitigation and for vaccination strategies amongst pwMS undergoing DMT.", "doi": "10.1111/ene.16015", "pmid": "37522464", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:09:27.597Z", "modified": "2023-10-04T12:53:25.039Z"}, {"entity": "publication", "iuid": "119a8efc353f427ea1abf28986ba5525", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/119a8efc353f427ea1abf28986ba5525.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/119a8efc353f427ea1abf28986ba5525"}}, "title": "Supportive public health leadership for COVID-19 response in Jordan.", "authors": [{"family": "Bellizzi", "given": "Saverio", "initials": "S"}, {"family": "Asghar", "given": "Humayun", "initials": "H"}, {"family": "Bile", "given": "Khalif", "initials": "K"}], "type": "case reports", "published": "2023-07-31", "journal": {"title": "East Mediterr Health J", "issn": "1687-1634", "issn-l": null, "volume": "29", "issue": "7", "pages": "575-579"}, "abstract": "The WHO Regional Office for the Eastern Mediterranean and the United Nations System Staff College (UNSSC) implemented a leadership programme on epidemic and pandemic preparedness and response, specific to the COVID-19 pandemic, during the second half of 2021.\r\n\r\nTo highlight the leadership role played by the WHO Jordan Country Office during the COVID-19 pandemic in collaboration with UNSSC.\r\n\r\nThe WHO Jordan country office successfully leveraged the expertise of UNSSC to implement a leadership training to prepare key stakeholders in Jordan for the response to COVID-19 and similar pandemics or outbreaks. The training curriculum included several modules such as leadership in times of crisis, strategic thinking and planning, emotional resilience, preparedness, adopting a system approach to response, and multisectoral partnership-building for pandemic response. The training helped strengthen the generation of evidence for policymaking and promotion of equitable access to health during the COVID-19 pandemic.\r\n\r\nLeadership capacity strengthening of national counterparts by WHO and partners can help advance efforts at national level to increase the use of evidence for policymaking and response to pandemics and disease outbreaks.", "doi": "10.26719/emhj.23.035", "pmid": "37553746", "labels": {"Category: Public Health": null, "Type: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-05T08:08:49.548Z", "modified": "2023-10-06T04:38:03.240Z"}, {"entity": "publication", "iuid": "3610fea119cc4cf5a9d702276b381831", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3610fea119cc4cf5a9d702276b381831.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3610fea119cc4cf5a9d702276b381831"}}, "title": "COVID-19 vaccine safety during pregnancy and breastfeeding in women with autoimmune diseases: results from the COVAD study.", "authors": [{"family": "Andreoli", "given": "Laura", "initials": "L"}, {"family": "Lini", "given": "Daniele", "initials": "D"}, {"family": "Schreiber", "given": "Karen", "initials": "K"}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Naveen", "given": "R", "initials": "R", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Jagtap", "given": "Kshitij", "initials": "K", "orcid": "0000-0003-2729-737X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822b9da98e5d4eb2975ff97fe484933f.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Saha", "given": "Sreoshy", "initials": "S", "orcid": "0000-0001-6745-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00238845dd4833ae51ffb75e2fe144.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Edgar Gracia-Ramos", "given": "Abraham", "initials": "A", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}, {"family": "Patel", "given": "Aarat", "initials": "A"}, {"family": "Pauling", "given": "John D", "initials": "JD", "orcid": "0000-0002-2793-2364", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e37709273d404d17a88c7c850777b99f.json"}}, {"family": "Wincup", "given": "Chris", "initials": "C", "orcid": "0000-0002-8742-8311", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a674f02e7f7f45f58167eb24f81502f3.json"}}, {"family": "Barman", "given": "Bhupen", "initials": "B"}, {"family": "Zamora Tehozol", "given": "Erick Adrian", "initials": "EA", "orcid": "0000-0002-7888-3961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a55c695ac4f4003993a2f511cca7739.json"}}, {"family": "Serrano", "given": "Jorge Rojas", "initials": "JR", "orcid": "0000-0001-6980-7898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/225fd8b396ac40f4a77f1ec229c086b6.json"}}, {"family": "Garc\u00eda-De La Torre", "given": "Ignacio", "initials": "I", "orcid": "0000-0002-9261-678X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/086b85d66fb84b50bd51bbe5a979dfe3.json"}}, {"family": "Colunga-Pedraza", "given": "Iris J", "initials": "IJ", "orcid": "0000-0002-2786-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50e46ef2c7f44b39a1d28fea6a8e621d.json"}}, {"family": "Merayo-Chalico", "given": "Javier", "initials": "J", "orcid": "0000-0002-5870-0523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d74c0ab33cbe4df586e1a1add37d0e65.json"}}, {"family": "Chibuzo", "given": "Okwara Celestine", "initials": "OC"}, {"family": "Katchamart", "given": "Wanruchada", "initials": "W", "orcid": "0000-0002-8952-5967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9439933b38fb49aca8fdbb5038ff603c.json"}}, {"family": "Akarawatcharangura Goo", "given": "Phonpen", "initials": "P"}, {"family": "Shumnalieva", "given": "Russka", "initials": "R", "orcid": "0000-0003-2321-6536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/933232cd7feb48ee81b5971f01f52e23.json"}}, {"family": "Chen", "given": "Yi-Ming", "initials": "Y"}, {"family": "Hoff", "given": "Leonardo Santos", "initials": "LS", "orcid": "0000-0002-2083-4796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1df7af8caf024ca39c57278fdf18c766.json"}}, {"family": "El Kibbi", "given": "Lina", "initials": "L", "orcid": "0000-0003-1710-9996", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11bb4fc524264c6897dec9642a0ef7cd.json"}}, {"family": "Halabi", "given": "Hussein", "initials": "H", "orcid": "0000-0002-5174-8292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb337090a5ab4461a07e8620bee1b4b9.json"}}, {"family": "Vaidya", "given": "Binit", "initials": "B", "orcid": "0000-0002-4840-8924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b2296d53fe14fc7a8415f26e03e1944.json"}}, {"family": "Sazliyana Shaharir", "given": "Syahrul", "initials": "S", "orcid": "0000-0002-9068-8114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1e6310979d44d58b548c61c733412af.json"}}, {"family": "Hasan", "given": "A T M Tanveer", "initials": "ATMT", "orcid": "0000-0002-5332-3319", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ffdb3329292438fac4005923ee79012.json"}}, {"family": "Dey", "given": "Dzifa", "initials": "D"}, {"family": "Guti\u00e9rrez", "given": "Carlos Enrique Toro", "initials": "CET", "orcid": "0000-0002-6084-7049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/980e455c5d114caaaefb6e0b55eaa3b3.json"}}, {"family": "Caballero-Uribe", "given": "Carlo V", "initials": "CV"}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "group", "given": "COVAD study", "initials": "Cs"}, {"family": ",", "given": "", "initials": ""}, {"family": "Chinoy", "given": "Gabriela Arredondo Hector", "initials": "GAH", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}], "type": "journal article", "published": "2023-07-28", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "We investigated COVID-19 vaccine safety in pregnant and breastfeeding women with autoimmune diseases (AID) in the COVID-19 Vaccination in Autoimmune Diseases (COVAD) study.\r\n\r\nDelayed-onset (>7 days) vaccine-related adverse events (AE), disease flares (DF), and AID-related treatment modifications were analyzed upon diagnosis of AID versus healthy controls (HC) and the pregnancy/breastfeeding status at the time of at least one dose of vaccine.\r\n\r\nAmong the 9201 participants to the self-administered online survey, 6787 (73.8%) were women. Forty pregnant and 52 breastfeeding patients with AID were identified, of whom the majority had received at least one dose of COVID-19 vaccine (100% and 96.2%, respectively). AE were reported significantly more frequently in pregnant than in non-pregnant patients (overall AE 45% vs 26%, p= 0.01; minor AE 40% vs 25.9%, p= 0.03; major AE 17.5% vs 4.6%, p< 0.01), but no difference was found in comparison with pregnant HC. No difference was observed between breastfeeding patients and HC with respect to AE. Post-vaccination DF were reported by 17.5% of pregnant and 20% of breastfeeding patients, and by 18.3% of age- and disease-matched non-pregnant and non-breastfeeding patients (n = 262). All pregnant/breastfeeding patients who experienced a DF were managed with glucocorticoids; 28.6% and 20% of them required initiation or change in immunosuppressants, respectively.\r\n\r\nThis study provides reassuring insights into the safety of COVID-19 vaccines administered to women with AID during the gestational and post-partum periods, helping overcome hesitant attitudes, as the benefits for the mother and the fetus by passive immunization appear to outweigh potential risks.", "doi": "10.1093/rheumatology/kead382", "pmid": "37505460", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "7233066"}], "notes": [], "created": "2023-10-04T12:10:03.914Z", "modified": "2023-10-04T13:08:59.955Z"}, {"entity": "publication", "iuid": "02865561b5ed4712a71ebd97c8baa32b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02865561b5ed4712a71ebd97c8baa32b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02865561b5ed4712a71ebd97c8baa32b"}}, "title": "Anxiety, concerns and COVID-19: Cross-country perspectives from families and individuals with neurodevelopmental conditions.", "authors": [{"family": "Sideropoulos", "given": "Vassilis", "initials": "V"}, {"family": "Van Herwegen", "given": "Jo", "initials": "J"}, {"family": "Meuleman", "given": "Ben", "initials": "B"}, {"family": "Alessandri", "given": "Michael", "initials": "M"}, {"family": "Alnemary", "given": "Faisal M", "initials": "FM"}, {"family": "Rad", "given": "Jamal Amani", "initials": "JA"}, {"family": "Lavenex", "given": "Pamela A Banta", "initials": "PAB"}, {"family": "Bolshakov", "given": "Nikita", "initials": "N"}, {"family": "B\u00f6lte", "given": "Sven", "initials": "S"}, {"family": "Buffle", "given": "Paulina", "initials": "P"}, {"family": "Cai", "given": "Ru Y", "initials": "RY"}, {"family": "Campos", "given": "Ruth", "initials": "R"}, {"family": "Chirita-Emandi", "given": "Adela", "initials": "A"}, {"family": "Costa", "given": "Andreia P", "initials": "AP"}, {"family": "Costanzo", "given": "Floriana", "initials": "F"}, {"family": "Des Portes", "given": "Vincent", "initials": "V"}, {"family": "Dukes", "given": "Daniel", "initials": "D"}, {"family": "Faivre", "given": "Laurence", "initials": "L"}, {"family": "Famelart", "given": "Nawelle", "initials": "N"}, {"family": "Fisher", "given": "Marisa H", "initials": "MH"}, {"family": "Gamaiunova", "given": "Liudmilla", "initials": "L"}, {"family": "Giannadou", "given": "Aikaterini", "initials": "A"}, {"family": "Gupta", "given": "Rashmi", "initials": "R"}, {"family": "Hardan", "given": "Antonio Y", "initials": "AY"}, {"family": "Houdayer-Robert", "given": "Fran\u00e7oise", "initials": "F"}, {"family": "Hrncirova", "given": "Lenka", "initials": "L"}, {"family": "Iaochite", "given": "Roberto Tadeu", "initials": "RT"}, {"family": "Jariabkova", "given": "Katarina", "initials": "K"}, {"family": "Klein-Tasman", "given": "Bonita P", "initials": "BP"}, {"family": "Lavenex", "given": "Pierre", "initials": "P"}, {"family": "Malik", "given": "Supriya", "initials": "S"}, {"family": "Mari", "given": "Francesca", "initials": "F"}, {"family": "Martinez-Castilla", "given": "Pastora", "initials": "P"}, {"family": "Menghini", "given": "Deny", "initials": "D"}, {"family": "Nuske", "given": "Heather J", "initials": "HJ"}, {"family": "Palikara", "given": "Olympia", "initials": "O"}, {"family": "Papon", "given": "Anouk", "initials": "A"}, {"family": "Pegg", "given": "Robin S", "initials": "RS"}, {"family": "Pouretemad", "given": "Hamidreza", "initials": "H"}, {"family": "Poustka", "given": "Luise", "initials": "L"}, {"family": "Prosetzky", "given": "Ingolf", "initials": "I"}, {"family": "Renieri", "given": "Alessandra", "initials": "A"}, {"family": "Rhodes", "given": "Sinead M", "initials": "SM"}, {"family": "Riby", "given": "Deborah M", "initials": "DM"}, {"family": "Rossi", "given": "Massimiliano", "initials": "M"}, {"family": "Sadeghi", "given": "Saeid", "initials": "S"}, {"family": "Su", "given": "Xueyen", "initials": "X"}, {"family": "Tai", "given": "Claire", "initials": "C"}, {"family": "Tran", "given": "Michel", "initials": "M"}, {"family": "Tynan", "given": "Fionnuala", "initials": "F"}, {"family": "Uljarevi\u0107", "given": "Mirko", "initials": "M"}, {"family": "Van Hecke", "given": "Amy V", "initials": "AV"}, {"family": "Veiga", "given": "Guida", "initials": "G"}, {"family": "Verloes", "given": "Alain", "initials": "A"}, {"family": "Vicari", "given": "Stefano", "initials": "S"}, {"family": "Werneck-Rohrer", "given": "Sonja G", "initials": "SG"}, {"family": "Zander", "given": "Eric", "initials": "E"}, {"family": "Samson", "given": "Andrea C", "initials": "AC"}], "type": "journal article", "published": "2023-07-28", "journal": {"title": "J Glob Health", "issn": "2047-2986", "issn-l": "2047-2978", "volume": "13", "issue": null, "pages": "04081"}, "abstract": "The COVID-19 pandemic had a major impact on the mental health and well-being of children with neurodevelopmental conditions (NDCs) and of their families worldwide. However, there is insufficient evidence to understand how different factors (e.g., individual, family, country, children) have impacted on anxiety levels of families and their children with NDCs developed over time.\r\n\r\nWe used data from a global survey assessing the experience of 8043 families and their children with NDCs (mean of age (m) = 13.18 years, 37% female) and their typically developing siblings (m = 12.9 years, 45% female) in combination with data from the European Centre for Disease Prevention and Control, the University of Oxford, and the Central Intelligence Agency (CIA) World Factbook, to create a multilevel data set. Using stepwise multilevel modelling, we generated child-, family- and country-related factors that may have contributed to the anxiety levels of children with NDCs, their siblings if they had any, and their parents. All data were reported by parents.\r\n\r\nOur results suggest that parental anxiety was best explained by family-related factors such as concerns about COVID-19 and illness. Children's anxiety was best explained by child-related factors such as children's concerns about loss of routine, family conflict, and safety in general, as well as concerns about COVID-19. In addition, anxiety levels were linked to the presence of pre-existing anxiety conditions for both children with NDCs and their parents.\r\n\r\nThe present study shows that across the globe there was a raise in anxiety levels for both parents and their children with NDCs because of COVID-19 and that country-level factors had little or no impact on explaining differences in this increase, once family and child factors were considered. Our findings also highlight that certain groups of children with NDCs were at higher risk for anxiety than others and had specific concerns. Together, these results show that anxiety of families and their children with NDCs during the COVID-19 pandemic were predicted by very specific concerns and worries which inform the development of future toolkits and policy. Future studies should investigate how country factors can play a protective role during future crises.", "doi": "10.7189/jogh.13.04081", "pmid": "37497751", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10373111"}], "notes": [], "created": "2023-10-04T12:10:01.287Z", "modified": "2023-10-04T13:08:11.013Z"}, {"entity": "publication", "iuid": "959d789ffbd645a49354b747833a4cba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/959d789ffbd645a49354b747833a4cba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/959d789ffbd645a49354b747833a4cba"}}, "title": "The Impact of the COVID-19 Pandemic on Cutaneous Drug Eruptions in a Swedish Health Region without Lockdown.", "authors": [{"family": "Pissa", "given": "Maria", "initials": "M"}, {"family": "Jerkovic Gulin", "given": "Sandra", "initials": "S"}], "type": "journal article", "published": "2023-07-27", "journal": {"title": "Microorganisms", "issn": "2076-2607", "issn-l": "2076-2607", "volume": "11", "issue": "8", "pages": null}, "abstract": "The incidence of severe cutaneous drug eruptions during the COVID-19 period in Sweden has not been studied previously. Our aim was to compare the incidence of these skin reactions in a Swedish health region during the COVID-19 pandemic period with that of the year after: we conducted a retrospective, observational cohort study using data from a national registry of patients diagnosed with cutaneous drug eruptions during the pandemic in Sweden. We included the number of patients diagnosed with severe cutaneous drug eruptions at the Department of Dermatology in the Jonkoping health region during the COVID-19 pandemic (1 April 2020 to 31 March 2021) and the reference period (1 April 2021 to 31 March 2022). We examined the monthly occurrences of cutaneous drug eruptions in three dermatology clinics within the Jonkoping health region. The frequency of these eruptions was determined for two distinct time periods: during the pandemic and post-pandemic. The study included 102 patients with cutaneous drug eruptions: 29 patients were diagnosed during the COVID-19 pandemic period and 73 were diagnosed during the reference period. The difference in the number of cutaneous drug eruptions cases (p-value = 0.0001, 95% CI 1.4995-3.5500, OR 2.3072) during the pandemic period compared to the post-pandemic period was significant. To our knowledge, the impact of the pandemic on cutaneous drug eruptions has not been investigated in EU countries. The increasing and differentiation of the number of diagnosed cutaneous drug eruptions cases after the pandemic could be explained by the removal of COVID-19 restrictions and the more frequent health-seeking behavior during the post-pandemic period.", "doi": "10.3390/microorganisms11081913", "pmid": "37630473", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10459394"}, {"db": "pii", "key": "microorganisms11081913"}], "notes": [], "created": "2023-10-05T08:08:42.023Z", "modified": "2023-10-06T04:31:38.188Z"}, {"entity": "publication", "iuid": "58384bfd215648a29216bdea3bb43ada", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/58384bfd215648a29216bdea3bb43ada.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/58384bfd215648a29216bdea3bb43ada"}}, "title": "Immune response to SARS-CoV-2 mRNA vaccination in multiple sclerosis patients after rituximab treatment interruption.", "authors": [{"family": "Gr\u00f6ning", "given": "Remigius", "initials": "R"}, {"family": "Dernstedt", "given": "Andy", "initials": "A"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Sundstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}], "type": "journal article", "published": "2023-07-27", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "1219560"}, "abstract": "Peripheral B cell depletion via anti-CD20 treatment is a highly effective disease-modifying treatment for reducing new relapses in multiple sclerosis (MS) patients. A drawback of rituximab (RTX) and other anti-CD20 antibodies is a poor immune response to vaccination. While this can be mitigated by treatment interruption of at least six months prior to vaccination, the timing to resume treatment while maintaining subsequent vaccine responses remains undetermined. Here, we characterized SARS-CoV-2 S-directed antibody and B cell responses throughout three BNT162b2 mRNA vaccine doses in RTX-treated MS patients, with the first two doses given during treatment interruption. We examined B-cell mediated immune responses in blood samples from patients with RTX-treated MS throughout three BNT162b2 vaccine doses, compared to an age- and sex-matched healthy control group. The first vaccine dose was given 1.3 years (median) after the last RTX infusion, the second dose one month after the first, and the third dose four weeks after treatment re-initiation. We analyzed SARS-CoV-2 S-directed antibody levels using enzyme-linked immunosorbent assay (ELISA), and the neutralization capacity of patient serum against SARS-CoV-2 S-pseudotyped lentivirus using luciferase reporter assay. In addition, we assessed switched memory (CD19+CD20+CD27+IgD-), unswitched memory (CD19+CD20+CD27+IgD+), na\u00efve (CD19+CD20+CD27-IgD+), and double negative (DN, CD19+CD20+CD27-IgD-) B cell frequencies, as well as their SARS-CoV-2 S-specific (CoV+) and Decay Accelerating Factor-negative (DAF-) subpopulations, using flow cytometry. After two vaccine doses, S-binding antibody levels and neutralization capacity in SARS-CoV-2-na\u00efve MS patients were comparable to vaccinated healthy controls, albeit with greater variation. Higher antibody response levels and CoV+-DN B cell frequencies after the second vaccine dose were predictive of a boost effect after the third dose, even after re-initiation of rituximab treatment. MS patients also exhibited lower frequencies of DAF- memory B cells, a suggested proxy for germinal centre activity, than control individuals. S-binding antibody levels in RTX-treated MS patients after two vaccine doses could help determine which individuals would need to move up their next vaccine booster dose or postpone their next RTX infusion. Our findings also offer first indications on the potential importance of antigenic stimulation of DN B cells and long-term impairment of germinal centre activity in rituximab-treated MS patients.", "doi": "10.3389/fimmu.2023.1219560", "pmid": "37575257", "labels": {"Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10413123"}], "notes": [], "created": "2023-10-05T08:26:16.770Z", "modified": "2023-10-06T04:53:07.553Z"}, {"entity": "publication", "iuid": "a3ff29086df3421ca10205e0fd0dc8c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3ff29086df3421ca10205e0fd0dc8c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3ff29086df3421ca10205e0fd0dc8c9"}}, "title": "Policies on children and schools during the SARS-CoV-2 pandemic in Western Europe.", "authors": [{"family": "Soriano-Arandes", "given": "Antoni", "initials": "A"}, {"family": "Brett", "given": "Ana", "initials": "A"}, {"family": "Buonsenso", "given": "Danilo", "initials": "D"}, {"family": "Emilsson", "given": "Louise", "initials": "L"}, {"family": "de la Fuente Garcia", "given": "Isabel", "initials": "I"}, {"family": "Gkentzi", "given": "Despoina", "initials": "D"}, {"family": "Helve", "given": "Otto", "initials": "O"}, {"family": "Kepp", "given": "Kasper P", "initials": "KP"}, {"family": "Mossberg", "given": "Maria", "initials": "M"}, {"family": "Muka", "given": "Taulant", "initials": "T"}, {"family": "Munro", "given": "Alasdair", "initials": "A"}, {"family": "Papan", "given": "Cihan", "initials": "C"}, {"family": "Perramon-Malavez", "given": "Aida", "initials": "A"}, {"family": "Schaltz-Buchholzer", "given": "Frederik", "initials": "F"}, {"family": "Smeesters", "given": "Pierre R", "initials": "PR"}, {"family": "Zimmermann", "given": "Petra", "initials": "P"}], "type": "journal article", "published": "2023-07-25", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "1175444"}, "abstract": "During the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), mitigation policies for children have been a topic of considerable uncertainty and debate. Although some children have co-morbidities which increase their risk for severe coronavirus disease (COVID-19), and complications such as multisystem inflammatory syndrome and long COVID, most children only get mild COVID-19. On the other hand, consistent evidence shows that mass mitigation measures had enormous adverse impacts on children. A central question can thus be posed: What amount of mitigation should children bear, in response to a disease that is disproportionally affecting older people? In this review, we analyze the distinct child versus adult epidemiology, policies, mitigation trade-offs and outcomes in children in Western Europe. The highly heterogenous European policies applied to children compared to adults did not lead to significant measurable differences in outcomes. Remarkably, the relative epidemiological importance of transmission from school-age children to other age groups remains uncertain, with current evidence suggesting that schools often follow, rather than lead, community transmission. Important learning points for future pandemics are summarized.", "doi": "10.3389/fpubh.2023.1175444", "pmid": "37564427", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10411527"}], "notes": [], "created": "2023-10-05T08:02:38.935Z", "modified": "2023-10-05T08:48:36.368Z"}, {"entity": "publication", "iuid": "5197070c0aaa4a3fa1e29395a456374d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5197070c0aaa4a3fa1e29395a456374d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5197070c0aaa4a3fa1e29395a456374d"}}, "title": "Comparative effectiveness of bivalent BA.4-5 and BA.1 mRNA booster vaccines among adults aged \u226550 years in Nordic countries: nationwide cohort study.", "authors": [{"family": "Andersson", "given": "Niklas Worm", "initials": "NW", "orcid": "0000-0001-7622-6303", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e4000bddcc34ce5987e9ccccc76a858.json"}}, {"family": "Thiesson", "given": "Emilia Myrup", "initials": "EM"}, {"family": "Baum", "given": "Ulrike", "initials": "U"}, {"family": "Pihlstr\u00f6m", "given": "Nicklas", "initials": "N"}, {"family": "Starrfelt", "given": "Jostein", "initials": "J"}, {"family": "Faksov\u00e1", "given": "Krist\u00fdna", "initials": "K"}, {"family": "Poukka", "given": "Eero", "initials": "E"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}, {"family": "Ljung", "given": "Rickard", "initials": "R"}, {"family": "Hviid", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2023-07-25", "journal": {"title": "BMJ", "issn": "1756-1833", "issn-l": null, "volume": "382", "issue": null, "pages": "e075286"}, "abstract": "To estimate the effectiveness of the bivalent mRNA booster vaccines containing the original SARS-CoV-2 and omicron BA.4-5 or BA.1 subvariants as the fourth dose against severe covid-19.\r\n\r\nNationwide cohort analyses, using target trial emulation.\r\n\r\nDenmark, Finland, Norway, and Sweden, from 1 July 2022 to 10 April 2023.\r\n\r\nPeople aged \u226550 years who had received at least three doses of covid-19 vaccine (that is, a primary course and a first booster).\r\n\r\nThe Kaplan-Meier estimator was used to compare the risk of hospital admission and death related to covid-19 in people who received a bivalent Comirnaty (Pfizer-BioNTech) or Spikevax (Moderna) BA.4-5 or BA.1 mRNA booster vaccine as a fourth dose (second booster) with three dose (first booster) vaccinated people and between four dose vaccinated people.\r\n\r\nA total of 1 634 199 people receiving bivalent BA.4-5 fourth dose booster and 1 042 124 receiving bivalent BA.1 fourth dose booster across the four Nordic countries were included. Receipt of a bivalent BA.4-5 booster as a fourth dose was associated with a comparative vaccine effectiveness against admission to hospital with covid-19 of 67.8% (95% confidence interval 63.1% to 72.5%) and a risk difference of -91.9 (95% confidence interval -152.4 to -31.4) per 100 000 people at three months of follow-up compared with having received three doses of vaccine (289 v 893 events). The corresponding comparative vaccine effectiveness and risk difference for bivalent BA.1 boosters (332 v 977 events) were 65.8% (59.1% to 72.4%) and -112.9 (-179.6 to -46.2) per 100 000, respectively. Comparative vaccine effectiveness and risk difference against covid-19 related death were 69.8% (52.8% to 86.8%) and -34.1 (-40.1 to -28.2) per 100 000 for bivalent BA.4-5 booster (93 v 325 events) and 70.0% (50.3% to 89.7%) and -38.7 (-65.4 to -12.0) per 100 000 for BA.1 booster (86 v 286) as a fourth dose. Comparing bivalent BA.4-5 and BA.1 boosters as a fourth dose directly resulted in a three month comparative vaccine effectiveness and corresponding risk difference of -14.9% (-62.3% to 32.4%) and 10.0 (-14.4 to 34.4) per 100 000 people for admission to hospital with covid-19 (802 v 932 unweighted events) and -40.7% (-123.4% to 42.1%) and 8.1 (-3.3 to 19.4) per 100 000 for covid-19 related death (229 v 243 unweighted events). The comparative vaccine effectiveness did not differ across sex and age (<\/\u226570 years) and seemed to be sustained up to six months from the day of vaccination with modest waning.\r\n\r\nVaccination with bivalent BA.4-5 or BA.1 mRNA booster vaccines as a fourth dose was associated with reduced rates of covid-19 related hospital admission and death among adults aged \u226550 years. The protection afforded by the bivalent BA.4-5 and BA.1 boosters did not differ significantly when directly compared, and any potential difference would most likely be very small in absolute numbers.", "doi": "10.1136/bmj-2022-075286", "pmid": "37491022", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10364194"}], "notes": [], "created": "2023-10-04T12:08:15.579Z", "modified": "2023-10-04T12:31:14.841Z"}, {"entity": "publication", "iuid": "0b66e9f896bc494991a0bbf34ef5df9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b66e9f896bc494991a0bbf34ef5df9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b66e9f896bc494991a0bbf34ef5df9c"}}, "title": "Comparative effectiveness of heterologous third dose vaccine schedules against severe covid-19 during omicron predominance in Nordic countries: population based cohort analyses.", "authors": [{"family": "Andersson", "given": "Niklas Worm", "initials": "NW", "orcid": "0000-0001-7622-6303", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e4000bddcc34ce5987e9ccccc76a858.json"}}, {"family": "Thiesson", "given": "Emilia Myrup", "initials": "EM"}, {"family": "Baum", "given": "Ulrike", "initials": "U"}, {"family": "Pihlstr\u00f6m", "given": "Nicklas", "initials": "N"}, {"family": "Starrfelt", "given": "Jostein", "initials": "J"}, {"family": "Faksov\u00e1", "given": "Krist\u00fdna", "initials": "K"}, {"family": "Poukka", "given": "Eero", "initials": "E"}, {"family": "Lund", "given": "Lars Christian", "initials": "LC"}, {"family": "Hansen", "given": "Christian Holm", "initials": "CH"}, {"family": "Aakj\u00e6r", "given": "Mia", "initials": "M"}, {"family": "Kj\u00e6r", "given": "Jesper", "initials": "J"}, {"family": "Cohet", "given": "Catherine", "initials": "C"}, {"family": "Goossens", "given": "Mathijs", "initials": "M"}, {"family": "Andersen", "given": "Morten", "initials": "M"}, {"family": "Hallas", "given": "Jesper", "initials": "J"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}, {"family": "Ljung", "given": "Rickard", "initials": "R"}, {"family": "Hviid", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2023-07-24", "journal": {"title": "BMJ", "issn": "1756-1833", "issn-l": null, "volume": "382", "issue": null, "pages": "e074325"}, "abstract": "To investigate the comparative vaccine effectiveness of heterologous booster schedules (ie, three vaccine doses) compared with primary schedules (two vaccine doses) and with homologous mRNA vaccine booster schedules (three vaccine doses) during a period of omicron predominance.\r\n\r\nPopulation based cohort analyses.\r\n\r\nDenmark, Finland, Norway, and Sweden, 27 December 2020 to 31 December 2022.\r\n\r\nAll adults aged \u226518 years who had received at least a primary vaccination schedule of AZD1222 (Oxford-AstraZeneca) or monovalent SARS-CoV-2 wild type (ancestral) strain based mRNA vaccines BNT162b2 (Pfizer-BioNTech) or mRNA-1273 (Moderna), in any combination.\r\n\r\nThe main outcome measure was country combined risks of covid-19 related hospital admission and death with covid-19 and additional outcomes of covid-19 related admission to an intensive care unit and SARS-CoV-2 infection. During a period of omicron predominance, these outcomes were compared in those who received a heterologous booster versus primary schedule (matched analyses) and versus those who received a homologous mRNA vaccine booster (weighted analyses). Follow-up was for 75 days from day 14 after the booster dose; comparative vaccine effectiveness was calculated as 1-risk ratio.\r\n\r\nAcross the four Nordic countries, 1 086 418 participants had received a heterologous booster schedule of AZD1222+BNT162b2 or mRNA-1273 and 2 505 093 had received a heterologous booster schedule of BNT162b2+mRNA-1273. Compared with the primary schedule only (two doses), the vaccine effectiveness of heterologous booster schedules comprising AZD1222+BNT162b2 or mRNA-1273 and BNT162b2+mRNA-1273 was 82.7% (95% confidence interval 77.1% to 88.2%) and 81.5% (78.9% to 84.2%) for covid-19 related hospital admission and 95.9% (91.6% to 100.0%) and 87.5% (82.5% to 92.6%) for death with covid-19, respectively. Homologous mRNA booster schedules were similarly associated with increased protection against covid-19 related hospital admission (\u226576.5%) and death with covid-19 (\u226584.1%) compared with previous primary course vaccination only. When a heterologous booster schedule was compared with the homologous booster schedule, vaccine effectiveness was 27.2% (3.7% to 50.6%) for AZD1222+BNT162b2 or mRNA-1273 and 23.3% (15.8% to 30.8%) for BNT162b2+mRNA-1273 schedules against covid-19 related hospital admission and 21.7% (-8.3% to 51.7%) and 18.4% (-15.7% to 52.5%) against death with covid-19, respectively.\r\n\r\nHeterologous booster schedules are associated with increased protection against severe, omicron related covid-19 outcomes compared with primary course schedules and homologous booster schedules.", "doi": "10.1136/bmj-2022-074325", "pmid": "37487623", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10360027"}], "notes": [], "created": "2023-10-04T12:07:43.563Z", "modified": "2023-10-04T12:23:39.030Z"}, {"entity": "publication", "iuid": "979c9b04b372456284e6e053caac01f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/979c9b04b372456284e6e053caac01f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/979c9b04b372456284e6e053caac01f4"}}, "title": "COVID-19-Induced Acute Respiratory Distress Syndrome Treated with Hyperbaric Oxygen: Interim Safety Report from a Randomized Clinical Trial (COVID-19-HBO).", "authors": [{"family": "Kjellberg", "given": "Anders", "initials": "A", "orcid": "0000-0002-4819-1024", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81941232265d46679c08c40c068e91c4.json"}}, {"family": "Douglas", "given": "Johan", "initials": "J"}, {"family": "Hassler", "given": "Adrian", "initials": "A"}, {"family": "Al-Ezerjawi", "given": "Sarah", "initials": "S"}, {"family": "Bostr\u00f6m", "given": "Emil", "initials": "E"}, {"family": "Abdel-Halim", "given": "Lina", "initials": "L"}, {"family": "Liwenborg", "given": "Lovisa", "initials": "L"}, {"family": "Hetting", "given": "Eric", "initials": "E"}, {"family": "Jonasdottir Nj\u00e5stad", "given": "Anna Dora", "initials": "AD"}, {"family": "Kowalski", "given": "Jan", "initials": "J"}, {"family": "Catrina", "given": "Sergiu-Bogdan", "initials": "S"}, {"family": "Rodriguez-Wallberg", "given": "Kenny A", "initials": "KA", "orcid": "0000-0003-4378-6181", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d45aa8a66f64858b4f9be050046e8a2.json"}}, {"family": "Lindholm", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2023-07-24", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "12", "issue": "14", "pages": null}, "abstract": "A few prospective trials and case series have suggested that hyperbaric oxygen therapy (HBOT) may be efficacious for the treatment of severe COVID-19, but safety is a concern for critically ill patients. We present an interim analysis of the safety of HBOT via a randomized controlled trial (COVID-19-HBO).\r\n\r\nA randomized controlled, open-label, clinical trial was conducted in compliance with good clinical practice to explore the safety and efficacy of HBOT for severe COVID-19 in critically ill patients with moderate acute respiratory distress syndrome (ARDS). Between 3 June 2020, and 17 May 2021, 31 patients with severe COVID-19 and moderate-to-severe ARDS, a ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FiO2) < 26.7 kPa (200 mmHg), and at least two defined risk factors for intensive care unit (ICU) admission and/or mortality were enrolled in the trial and randomized 1:1 to best practice, or HBOT in addition to best practice. The subjects allocated to HBOT received a maximum of five treatments at 2.4 atmospheres absolute (ATA) for 80 min over seven days. The subjects were followed up for 30 days. The safety endpoints were analyzed.\r\n\r\nAdverse events (AEs) were common. Hypoxia was the most common adverse event reported. There was no statistically significant difference between the groups. Numerically, serious adverse events (SAEs) and barotrauma were more frequent in the control group, and the differences between groups were in favor of the HBOT in PaO2/FiO2 (PFI) and the national early warning score (NEWS); statistically, however, the differences were not significant at day 7, and no difference was observed for the total oxygen burden and cumulative pulmonary oxygen toxicity dose (CPTD).\r\n\r\nHBOT appears to be safe as an intervention for critically ill patients with moderate-to-severe ARDS induced by COVID-19.\r\n\r\nNCT04327505 (31 March 2020) and EudraCT 2020-001349-37 (24 April 2020).", "doi": "10.3390/jcm12144850", "pmid": "37510965", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10381696"}, {"db": "pii", "key": "jcm12144850"}, {"db": "ClinicalTrials.gov", "key": "NCT04327505"}], "notes": [], "created": "2023-10-04T12:09:00.800Z", "modified": "2023-10-04T12:46:57.143Z"}, {"entity": "publication", "iuid": "3a6da6658c9b475c8daae7db7eee70c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a6da6658c9b475c8daae7db7eee70c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a6da6658c9b475c8daae7db7eee70c9"}}, "title": "The European experience with testing and surveillance during the first phase of the COVID-19 pandemic.", "authors": [{"family": "Stoto", "given": "Michael A", "initials": "MA", "orcid": "0000-0001-8293-471X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0312d97d6e2d4101b691bae6dbec98cb.json"}}, {"family": "Reno", "given": "Chiara", "initials": "C"}, {"family": "Tsolova", "given": "Svetla", "initials": "S"}, {"family": "Fantini", "given": "Maria Pia", "initials": "MP"}], "type": "journal article", "published": "2023-07-21", "journal": {"title": "Global Health", "issn": "1744-8603", "issn-l": "1744-8603", "volume": "19", "issue": "1", "pages": "51"}, "abstract": "COVID-19 pandemic provides a unique opportunity to learn the challenges encountered by public health emergency preparedness systems, both in terms of problems encountered and adaptations during and after the first wave, as well as successful responses to them.\r\n\r\nThis work draws on published literature, interviews with countries and institutional documents as part of a European Centre for Disease Prevention and Control project that aims to identify the implications for preparedness measurement derived from COVID-19 pandemic experience in order to advance future preparedness efforts in European Union member states. The analysis focused on testing and surveillance themes and five countries were considered, namely Italy, Germany, Finland, Spain and Croatia. Our analysis shown that a country's ability to conduct testing at scale was critical, especially early in the pandemic, and the inability to scale up testing operations created critical issues for public health operations such as contact tracing. Countries were required to develop new strategies, approaches, and policies under pressure and to review and revise them as the pandemic evolved, also considering that public health systems operate at the national, regional, and local level with respect to testing, contact tracing, and surveillance, and involve both government agencies as well as private organizations. Therefore, communication among multiple public and private entities at all levels and coordination of the testing and surveillance activities was critical.\r\n\r\nWith regard to testing and surveillance, three capabilities that were essential to the COVID-19 response in the first phase, and presumably in other public health emergencies: the ability to scale-up testing, contact tracing, surveillance efforts; flexibility to develop new strategies, approaches, and policies under pressure and to review and revise them as the pandemic evolved; and the ability to coordinate and communicate in complex public health systems that operate at the national, regional, and local level with respect and involve multiple government agencies as well as private organizations.", "doi": "10.1186/s12992-023-00950-9", "pmid": "37480125", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10362750"}, {"db": "pii", "key": "10.1186/s12992-023-00950-9"}], "notes": [], "created": "2023-10-04T12:09:51.345Z", "modified": "2023-10-04T13:03:47.580Z"}, {"entity": "publication", "iuid": "160193d3938347ad86b525744a2c8d29", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/160193d3938347ad86b525744a2c8d29.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/160193d3938347ad86b525744a2c8d29"}}, "title": "The Swedish COVID-19 approach: a scientific dialogue on mitigation policies.", "authors": [{"family": "Bj\u00f6rkman", "given": "Anders", "initials": "A"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Gullberg", "given": "Martin", "initials": "M"}, {"family": "Ludvigsson", "given": "Johnny", "initials": "J"}], "type": "journal article", "published": "2023-07-20", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "1206732"}, "abstract": "During the COVID-19 pandemic, Sweden was among the few countries that did not enforce strict lockdown measures but instead relied more on voluntary and sustainable mitigation recommendations. While supported by the majority of Swedes, this approach faced rapid and continuous criticism. Unfortunately, the respectful debate centered around scientific evidence often gave way to mudslinging. However, the available data on excess all-cause mortality rates indicate that Sweden experienced fewer deaths per population unit during the pandemic (2020-2022) than most high-income countries and was comparable to neighboring Nordic countries through the pandemic. An open, objective scientific dialogue is essential for learning and preparing for future outbreaks.", "doi": "10.3389/fpubh.2023.1206732", "pmid": "37546333", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10399217"}], "notes": [], "created": "2023-10-05T08:26:19.099Z", "modified": "2023-10-06T04:54:29.036Z"}, {"entity": "publication", "iuid": "17188b1b0b85452b82f931ef6a1c0098", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/17188b1b0b85452b82f931ef6a1c0098.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/17188b1b0b85452b82f931ef6a1c0098"}}, "title": "Making things work-In spite of a pandemic small scale enterprise managers' approach to business changes and health issues.", "authors": [{"family": "Landstad", "given": "Bodil J", "initials": "BJ", "orcid": "0000-0001-6558-3129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bdb9f75451d4f2b8c87a8f8a837a09d.json"}}, {"family": "Hedlund", "given": "Marianne", "initials": "M", "orcid": "0000-0002-1789-2477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d8e2939573845109d470f05b8314cee.json"}}, {"family": "Tjulin", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Nordenmark", "given": "Mikael", "initials": "M"}, {"family": "Vinberg", "given": "Stig", "initials": "S"}], "type": "journal article", "published": "2023-07-20", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "7", "pages": "e0288837"}, "abstract": "Covid-19 is one of the worst crises in modern working life with a direct negative impact on many enterprises and organizations. The aim of this study is to explore what managers in Small Scale Enterprises (SSEs) changed in their business during the Covid-19 pandemic, particularly addressing health issues.\r\n\r\nA longitudinal qualitative research methodology was used, interviewing 16 managers of SSEs in the Norwegian and Swedish manufacturing and service sector both before (round 1) and during the pandemic (round 2). In this approach, time is designed into the research process, making change a key focus for analysis.\r\n\r\nThe analysis resulted in two main themes, resilience and demanding occupational health and safety conditions, and five sub-themes. Results show how managers in SSEs changed their business during the Covid-19 pandemic and the impact of these changes. Although, the enterprises were heavily affected in the beginning of the pandemic, several managers found new solutions for their businesses to maintain and reach new customers. They applied a socially responsible management which addressed different health issues.\r\n\r\nCrises like the Covid-19 pandemic will have future impact on SSEs making it important to understand how managers in such enterprises address business and health issues. This knowledge may have practical implications for supporting managers in SSEs in how to perform a socially responsible management and maintain occupational health and safety measures. The managerial implications from this research are that they need to be flexible, reorientable and, at the same time, be loyal to the core business. This study shows the importance of doing longitudinal studies about business and health issues among mangers in SSEs.", "doi": "10.1371/journal.pone.0288837", "pmid": "37471417", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10358884"}, {"db": "pii", "key": "PONE-D-22-33735"}], "notes": [], "created": "2023-10-04T12:08:53.047Z", "modified": "2023-10-04T12:44:21.257Z"}, {"entity": "publication", "iuid": "8e0ff59d5c834afea39bb6f6652728e9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e0ff59d5c834afea39bb6f6652728e9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e0ff59d5c834afea39bb6f6652728e9"}}, "title": "Assessing the Knowledge, Attitudes, and Vaccination Practices Towards COVID-19 Vaccination Among Mainland Chinese Nursing Students and Interns: A Multicenter Cross-Sectional Study.", "authors": [{"family": "Qin", "given": "Zhuzhu", "initials": "Z"}, {"family": "Ye", "given": "Xinxin", "initials": "X"}, {"family": "Liu", "given": "Huanju", "initials": "H", "orcid": "0000-0002-3370-4296", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51415df31c7340ebb01f7537f1a86fce.json"}}, {"family": "Tao", "given": "Yining", "initials": "Y"}, {"family": "Zheng", "given": "Xutong", "initials": "X"}, {"family": "Zhong", "given": "Yanxia", "initials": "Y"}, {"family": "Chen", "given": "Danfeng", "initials": "D"}, {"family": "Ye", "given": "Wan", "initials": "W"}, {"family": "Zhan", "given": "Chenju", "initials": "C"}], "type": "journal article", "published": "2023-07-20", "journal": {"title": "Infect Drug Resist", "issn": "1178-6973", "issn-l": null, "volume": "16", "issue": null, "pages": "4717-4728"}, "abstract": "This study investigated factors influencing the knowledge, attitudes, practice profiles, and vaccination intentions among Chinese nursing students and nursing interns toward the coronavirus disease (COVID-19) vaccination.\r\n\r\nThe multicenter cross-sectional study was based on a self-reported questionnaire collecting information among nursing students and nursing interns from three major geographic regions of China, and the sample was selected by consecutive sampling. The questionnaire was developed by knowledge, attitudes, and practice (KAP) theory. Univariate and multivariate logistic regression were used for statistical analysis.\r\n\r\nA total of 3180 nursing students and interns (effective rate: 99.8%) from six Chinese provinces were polled. The vaccine hesitation rate was 9.65% (307/3180), 2230 participants (70.1%) had gotten at least one dose of the vaccine, and 643 participants (67.7%) had indicated a readiness to be vaccinated. The results showed that older age, higher academic background, perfect vaccine management, others' recommendations, influenza vaccination history, epidemic under control, knowledge of vaccines or intervals, and vaccine knowledge training were associated with higher vaccination rates. Conversely, vaccine hesitancy was caused by a perceived lack of physical need, uncertainty about vaccination requirements, and fear of vaccination.\r\n\r\nThis study provided population-based estimates of COVID-19 vaccine uptake intention among mainland Chinese nursing students and interns. Factors such as age, education, vaccine knowledge, and attitudes influence COVID-19 vaccine behaviour. Relevant authorities should understand the barriers to COVID-19 vaccination from knowledge, attitude and practice, which is significant for formulating effective response strategies in future global public health crises.", "doi": "10.2147/IDR.S415799", "pmid": "37496694", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10366673"}, {"db": "pii", "key": "415799"}], "notes": [], "created": "2023-10-04T12:09:53.826Z", "modified": "2023-10-04T13:04:36.946Z"}, {"entity": "publication", "iuid": "cf40e0b6004f481a992235ec3e50a034", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cf40e0b6004f481a992235ec3e50a034.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cf40e0b6004f481a992235ec3e50a034"}}, "title": "Understanding concerns after severe COVID-19: A self-imposed lockdown guarded by anxiety?", "authors": [{"family": "T\u00f6rnbom", "given": "Karin", "initials": "K", "orcid": "0000-0002-7593-2051", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64aa524f1b9d4b6a8e14312c6b298546.json"}}, {"family": "Larsson", "given": "Alexandra", "initials": "A"}, {"family": "Sunnerhagen", "given": "Katharina S", "initials": "KS"}, {"family": "Palstam", "given": "Annie", "initials": "A"}, {"family": "Persson", "given": "Hanna C", "initials": "HC"}], "type": "journal article", "published": "2023-07-19", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "7", "pages": "e0287981"}, "abstract": "Many people are struggling to get back to their lives after severe COVID-19. To facilitate their reintegration into everyday life, we need to understand how the process is experienced. We aimed to gain deeper knowledge about this process by interviewing persons one year after hospitalisation due to COVID-19.\r\n\r\nThe study is based on a qualitative design, with eleven in-depth interviews conducted one year after discharge for COVID-19. Participants were recruited to form a heterogeneous sample with respect to age, gender and socioeconomic background. All interviews were analysed utilising inductive thematic analysis.\r\n\r\nFrom the participants' narratives four themes were identified: 'Concerns and worries in everyday life', 'Supportive and concerned relatives', 'A new way of life-sorrows and advantages' and 'Seize the day-a greater awareness of one\u00b4s mortality'. Participants described how they tried to create a functioning everyday life. They were generally afraid of getting COVID-19 again and concerned about future life, where their lack of energy played a major role. Narratives were diverse regarding to what extent the struggle to cope was experienced as emotionally challenging or not.\r\n\r\nParticipants described an unpredictable recovery after COVID-19, characterised by ups and downs, which created worries concerning their future. In some cases, the worry of getting COVID-19 again was strong enough to keep participants in their homes, as a self-imposed lockdown guarded by anxiety. However, the narratives also revealed gratitude towards being alive and having coped so well. This led to a more positive outlook on life with a greater focus on intrinsic values, close social relations and the deeper meaning of life.", "doi": "10.1371/journal.pone.0287981", "pmid": "37467220", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10355428"}, {"db": "pii", "key": "PONE-D-22-34035"}], "notes": [], "created": "2023-10-04T12:08:26.208Z", "modified": "2023-10-04T12:35:13.421Z"}, {"entity": "publication", "iuid": "84926b3365624d769652f76338c3b874", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84926b3365624d769652f76338c3b874.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84926b3365624d769652f76338c3b874"}}, "title": "Totality of evidence of the effectiveness of repurposed therapies for COVID-19: Can we use real-world studies alongside randomized controlled trials?", "authors": [{"family": "Mandema", "given": "Jaap", "initials": "J"}, {"family": "Montgomery", "given": "Hugh", "initials": "H"}, {"family": "Dron", "given": "Louis", "initials": "L"}, {"family": "Fu", "given": "Shuai", "initials": "S", "orcid": "0000-0003-1889-3030", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f6c25a0a15240dbace467b7b5b2869e.json"}}, {"family": "Russek-Cohen", "given": "Estelle", "initials": "E"}, {"family": "Bromley", "given": "Christina", "initials": "C"}, {"family": "Mouksassi", "given": "Samer", "initials": "S", "orcid": "0000-0002-7152-6654", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f160080128543c0bb3ff50d0c56f091.json"}}, {"family": "Lalonde", "given": "Amy", "initials": "A"}, {"family": "Springford", "given": "Aaron", "initials": "A", "orcid": "0000-0001-7179-9049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa09157725754184ae5d22671b82af21.json"}}, {"family": "Tsai", "given": "Larry", "initials": "L", "orcid": "0000-0002-4787-2100", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/866e5b6ff6b54c2a8ac0d8b7170aef13.json"}}, {"family": "Ambery", "given": "Phil", "initials": "P"}, {"family": "McNair", "given": "Doug", "initials": "D"}, {"family": "Qizilbash", "given": "Nawab", "initials": "N"}, {"family": "Pocock", "given": "Stuart", "initials": "S"}, {"family": "Zariffa", "given": "N\u00e9vine", "initials": "N", "orcid": "0000-0001-7412-2260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b43d74bd08504288860d6a0ad7ea82c3.json"}}], "type": "journal article", "published": "2023-07-19", "journal": {"title": "Clin Transl Sci", "issn": "1752-8062", "issn-l": "1752-8054", "volume": null, "issue": null, "pages": null}, "abstract": "Rapid and robust strategies to evaluate the efficacy and effectiveness of novel and existing pharmacotherapeutic interventions (repurposed treatments) in future pandemics are required. Observational \"real-world studies\" (RWS) can report more quickly than randomized controlled trials (RCTs) and would have value were they to yield reliable results. Both RCTs and RWS were deployed during the coronavirus disease 2019 (COVID-19) pandemic. Comparing results between them offers a unique opportunity to determine the potential value and contribution of each. A learning review of these parallel evidence channels in COVID-19, based on quantitative modeling, can help improve speed and reliability in the evaluation of repurposed therapeutics in a future pandemic. Analysis of all-cause mortality data from 249 observational RWS and RCTs across eight treatment regimens for COVID-19 showed that RWS yield more heterogeneous results, and generally overestimate the effect size subsequently seen in RCTs. This is explained in part by a few study factors: the presence of RWS that are imbalanced for age, gender, and disease severity, and those reporting mortality at 2 weeks or less. Smaller studies of either type contributed negligibly. Analysis of evidence generated sequentially during the pandemic indicated that larger RCTs drive our ability to make conclusive decisions regarding clinical benefit of each treatment, with limited inference drawn from RWS. These results suggest that when evaluating therapies in future pandemics, (1) large RCTs, especially platform studies, be deployed early; (2) any RWS should be large and should have adequate matching of known confounders and long follow-up; (3) reporting standards and data standards for primary endpoints, explanatory factors, and key subgroups should be improved; in addition, (4) appropriate incentives should be in place to enable access to patient-level data; and (5) an overall aggregate view of all available results should be available at any given time.", "doi": "10.1111/cts.13591", "pmid": "37466279", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:10:13.332Z", "modified": "2023-10-04T13:11:17.887Z"}, {"entity": "publication", "iuid": "75b38a566c9a47e8a475fbbdd05169c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/75b38a566c9a47e8a475fbbdd05169c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/75b38a566c9a47e8a475fbbdd05169c5"}}, "title": "Quality of Life in Healthcare Workers during COVID-19-A Longitudinal Study.", "authors": [{"family": "Jungmar Ridell", "given": "Robin", "initials": "R", "orcid": "0009-0001-1877-427X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/248c00c2b3da4b11bb4b7c39e97e899a.json"}}, {"family": "Orvelius", "given": "Lotti", "initials": "L", "orcid": "0000-0002-8641-8656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22194893b9b94b068cda439a33af1b69.json"}}], "type": "journal article", "published": "2023-07-19", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "20", "issue": "14", "pages": null}, "abstract": "The COVID-19 pandemic occurred in 2020, and affected people's daily life worldwide at work and at home. Healthcare workers are a professional group with heavy workloads, and during the COVID-19 pandemic, their burden increased. The literature from earlier outbreaks describes risks for affected mental health in frontline workers, and the main aim of this study is to examine healthcare workers' quality of life during the COVID-19 pandemic. In addition, we sought to assess if there was any difference in working at a pandemic ward compared to anon-pandemic ward. In this longitudinal and descriptive study, a total of 147 healthcare workers assessed their perceived health every third month over one year using the RAND-36 health survey. RAND-36 is a general instrument that consists of 36 questions and is widely used for assessing quality of life. The healthcare workers in this study showed reductions in perceived quality of life during the first six months of the COVID-19 pandemic. Healthcare workers on a pandemic ward reported a lower score in RAND-36 compared to healthcare workers on a non-pandemic ward. Registered nurses and licensed practical nurses seemed more negatively affected in their quality of life than physicians. Compared to data from the general Swedish population, healthcare workers in this study had less energy during this period.", "doi": "10.3390/ijerph20146397", "pmid": "37510629", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10379197"}, {"db": "pii", "key": "ijerph20146397"}], "notes": [], "created": "2023-10-04T12:08:55.593Z", "modified": "2023-10-04T12:45:15.220Z"}, {"entity": "publication", "iuid": "f0d3d0fe64e8498f872585e04df58e78", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f0d3d0fe64e8498f872585e04df58e78.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f0d3d0fe64e8498f872585e04df58e78"}}, "title": "Protective immunity induced by an inhaled SARS-CoV-2 subunit vaccine.", "authors": [{"family": "Elder", "given": "Elizabeth", "initials": "E"}, {"family": "Bangalore Revanna", "given": "Chandrashekar", "initials": "C"}, {"family": "Johansson", "given": "Catharina", "initials": "C"}, {"family": "Wallin", "given": "Robert P A", "initials": "RPA"}, {"family": "Sj\u00f6dahl", "given": "Johan", "initials": "J"}, {"family": "Winqvist", "given": "Ola", "initials": "O"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}], "type": "journal article", "published": "2023-07-19", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null, "volume": "41", "issue": "32", "pages": "4743-4751"}, "abstract": "Targeting the site of infection is a promising strategy for improving vaccine effectivity. To date, licensed COVID-19 vaccines have been administered intramuscularly despite the fact that SARS-CoV-2 is a respiratory virus. Here, we aim to induce local protective mucosal immune responses with an inhaled subunit vaccine candidate, ISR52, based on the SARS-CoV-2 Spike S1 protein. When tested in a lethal challenge hACE2 transgenic SARS-CoV-2 mouse model, intranasal and intratracheal administration of ISR52 provided superior protection against severe infection, compared to the subcutaneous injection of the vaccine. Interestingly for a protein-based vaccine, inhaled ISR52 elicited both CD4 and CD8 T-cell Spike-specific responses that were maintained for at least 6 months in wild-type mice. Induced IgG and IgA responses cross-reacting with several SARS- CoV-2 variants of concern were detected in the lung and in serum and protected animals displayed neutralizing antibodies. Based on our results, we are developing ISR52 as a dry powder formulation for inhalation, that does not require cold-chain distribution or the use of needle administration, for evaluation in a Phase I/II clinical trial.", "doi": "10.1016/j.vaccine.2023.06.015", "pmid": "37353452", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10242152"}, {"db": "pii", "key": "S0264-410X(23)00684-9"}], "notes": [], "created": "2023-10-04T09:29:58.130Z", "modified": "2023-10-04T09:42:25.916Z"}, {"entity": "publication", "iuid": "53d5d83a2a0443efb9a916f3b7ae1622", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53d5d83a2a0443efb9a916f3b7ae1622.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53d5d83a2a0443efb9a916f3b7ae1622"}}, "title": "European Society of Breast Imaging (EUSOBI) guidelines on the management of axillary lymphadenopathy after COVID-19 vaccination: 2023 revision.", "authors": [{"family": "Schiaffino", "given": "Simone", "initials": "S"}, {"family": "Pinker", "given": "Katja", "initials": "K", "orcid": "0000-0002-2722-7331", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a70e813e2dcb4580a6df060773885849.json"}}, {"family": "Cozzi", "given": "Andrea", "initials": "A"}, {"family": "Magni", "given": "Veronica", "initials": "V"}, {"family": "Athanasiou", "given": "Alexandra", "initials": "A"}, {"family": "Baltzer", "given": "Pascal A T", "initials": "PAT"}, {"family": "Camps Herrero", "given": "Julia", "initials": "J"}, {"family": "Clauser", "given": "Paola", "initials": "P"}, {"family": "Fallenberg", "given": "Eva M", "initials": "EM"}, {"family": "Forrai", "given": "Gabor", "initials": "G"}, {"family": "Fuchsj\u00e4ger", "given": "Michael H", "initials": "MH"}, {"family": "Gilbert", "given": "Fiona J", "initials": "FJ"}, {"family": "Helbich", "given": "Thomas", "initials": "T"}, {"family": "Kilburn-Toppin", "given": "Fleur", "initials": "F"}, {"family": "Kuhl", "given": "Christiane K", "initials": "CK"}, {"family": "Lesaru", "given": "Mihai", "initials": "M"}, {"family": "Mann", "given": "Ritse M", "initials": "RM"}, {"family": "Panizza", "given": "Pietro", "initials": "P"}, {"family": "Pediconi", "given": "Federica", "initials": "F"}, {"family": "Sardanelli", "given": "Francesco", "initials": "F"}, {"family": "Sella", "given": "Tamar", "initials": "T"}, {"family": "Thomassin-Naggara", "given": "Isabelle", "initials": "I"}, {"family": "Zackrisson", "given": "Sophia", "initials": "S"}, {"family": "Pijnappel", "given": "Ruud M", "initials": "RM"}], "type": "journal article", "published": "2023-07-19", "journal": {"title": "Insights Imaging", "issn": "1869-4101", "issn-l": null, "volume": "14", "issue": "1", "pages": "126"}, "abstract": "Axillary lymphadenopathy is a common side effect of COVID-19 vaccination, leading to increased imaging-detected asymptomatic and symptomatic unilateral axillary lymphadenopathy. This has threatened to negatively impact the workflow of breast imaging services, leading to the release of ten recommendations by the European Society of Breast Imaging (EUSOBI) in August 2021. Considering the rapidly changing scenario and data scarcity, these initial recommendations kept a highly conservative approach. As of 2023, according to newly acquired evidence, EUSOBI proposes the following updates, in order to reduce unnecessary examinations and avoid delaying necessary examinations. First, recommendation n. 3 has been revised to state that breast examinations should not be delayed or rescheduled because of COVID-19 vaccination, as evidence from the first pandemic waves highlights how delayed or missed screening tests have a negative effect on breast cancer morbidity and mortality, and that there is a near-zero risk of subsequent malignant findings in asymptomatic patients who have unilateral lymphadenopathy and no suspicious breast findings. Second, recommendation n. 7 has been revised to simplify follow-up strategies: in patients without breast cancer history and no imaging findings suspicious for cancer, symptomatic and asymptomatic imaging-detected unilateral lymphadenopathy on the same side of recent COVID-19 vaccination (within 12 weeks) should be classified as a benign finding (BI-RADS 2) and no further work-up should be pursued. All other recommendations issued by EUSOBI in 2021 remain valid.", "doi": "10.1186/s13244-023-01453-2", "pmid": "37466753", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Imaging": null}, "xrefs": [{"db": "pmc", "key": "PMC10356714"}, {"db": "pii", "key": "10.1186/s13244-023-01453-2"}], "notes": [], "created": "2023-10-04T12:10:08.468Z", "modified": "2023-10-04T13:09:53.088Z"}, {"entity": "publication", "iuid": "f224c212d8b649c6930ea0c2c55cb72c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f224c212d8b649c6930ea0c2c55cb72c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f224c212d8b649c6930ea0c2c55cb72c"}}, "title": "A novel indicator of selection in utero.", "authors": [{"family": "Catalano", "given": "Ralph", "initials": "R", "orcid": "0000-0001-7240-415X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ccf81f67c4f46dc92acca88a7344cc9.json"}}, {"family": "Bruckner", "given": "Tim A", "initials": "TA"}, {"family": "Gemmill", "given": "Alison", "initials": "A", "orcid": "0000-0001-5879-9730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dca36e3db9724dce8360c5f7b362151d.json"}}, {"family": "Casey", "given": "Joan A", "initials": "JA", "orcid": "0000-0002-9809-4695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e83f9b0e8a194572a5769025b1fe611f.json"}}, {"family": "Margerison", "given": "Claire", "initials": "C", "orcid": "0000-0003-0692-2252", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06be6014da274b2886af1733870d98b0.json"}}, {"family": "Hartig", "given": "Terry", "initials": "T"}], "type": "journal article", "published": "2023-07-19", "journal": {"title": "Evol Med Public Health", "issn": "2050-6201", "issn-l": null, "volume": "11", "issue": "1", "pages": "244-250"}, "abstract": "Selection in utero predicts that population stressors raise the standard for how quickly fetuses must grow to avoid spontaneous abortion. Tests of this prediction must use indirect indicators of fetal loss in birth cohorts because vital statistics systems typically register fetal deaths at the 20th week of gestation or later, well after most have occurred. We argue that tests of selection in utero would make greater progress if researchers adopted an indicator of selection against slow-growing fetuses that followed from theory, allowed sex-specific tests and used readily available data. We propose such an indicator and assess its validity as a dependent variable by comparing its values among monthly birth cohorts before, and during, the first 10 months of the COVID-19 pandemic in Sweden.\r\n\r\nWe apply Box-Jenkins methods to 50 pre-pandemic birth cohorts (i.e., December 2016 through January 2020) and use the resulting transfer functions to predict counterfactual values in our suggested indicator for selection for ten subsequent birth cohorts beginning in February 2020. We then plot all 60 residual values as well as their 95% detection interval. If birth cohorts in gestation at the onset of the pandemic lost more slow-growing fetuses than expected from history, more than one of the last 10 (i.e. pandemic-exposed) residuals would fall below the detection interval.\r\n\r\nFour of the last 10 residuals of our indicator for males and for females fell below the 95% detection interval.\r\n\r\nConsistent with selection in utero, Swedish birth cohorts in gestation at the outset of the COVID-19 pandemic included fewer than expected infants who grew slowly in utero.", "doi": "10.1093/emph/eoad018", "pmid": "37485055", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10360163"}, {"db": "pii", "key": "eoad018"}], "notes": [], "created": "2023-10-04T12:10:36.917Z", "modified": "2023-10-04T13:27:54.501Z"}, {"entity": "publication", "iuid": "861bb5ecaf5e4ceca3d0fe78c08c0c07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/861bb5ecaf5e4ceca3d0fe78c08c0c07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/861bb5ecaf5e4ceca3d0fe78c08c0c07"}}, "title": "Relative effectiveness of monovalent and bivalent mRNA boosters in preventing severe COVID-19 due to omicron BA.5 infection up to 4 months post-administration in people aged 60 years or older in Italy: a retrospective matched cohort study.", "authors": [{"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Sacco", "given": "Chiara", "initials": "C"}, {"family": "Fotakis", "given": "Emmanouil Alexandros", "initials": "EA"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Bressi", "given": "Marco", "initials": "M"}, {"family": "Rota", "given": "Maria Cristina", "initials": "MC"}, {"family": "Petrone", "given": "Daniele", "initials": "D"}, {"family": "Siddu", "given": "Andrea", "initials": "A"}, {"family": "Fedele", "given": "Giorgio", "initials": "G"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Palamara", "given": "Anna Teresa", "initials": "AT"}, {"family": "Brusaferro", "given": "Silvio", "initials": "S"}, {"family": "Rezza", "given": "Giovanni", "initials": "G"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}], "type": "journal article", "published": "2023-07-18", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Limited evidence is available on the additional protection conferred by second mRNA vaccine boosters against severe COVID-19 caused by omicron BA.5 infection, and whether the adapted bivalent boosters provide additional protection compared with the monovalent ones. In this study, we aimed to estimate the relative effectiveness of a second booster with monovalent or bivalent mRNA vaccines against severe COVID-19 in Italy.\r\n\r\nLinking data from the Italian vaccination registry and the SARS-CoV-2 surveillance system, between Sept 12, 2022, and Jan 7, 2023, we matched 1:1 each person aged 60 years or older receiving a second booster with a person who had received the first booster only at least 120 days earlier. We used hazard ratios, estimated through Cox proportional hazard models, to compare the hazard of severe COVID-19 between the first booster group and each type of second booster (monovalent mRNA vaccine targeting the original strain of SARS-CoV-2, bivalent mRNA vaccine targeting the original strain plus omicron BA.1 [bivalent original/BA.1], and bivalent mRNA vaccine targeting the original strain plus omicron BA.4 and BA.5 [bivalent original/BA.4-5]). Relative vaccine effectiveness (rVE) was calculated as (1-hazard ratio) \u00d7 100.\r\n\r\nWe analysed a total of 2 129 559 matched pairs. The estimated rVE against severe COVID-19 with the bivalent original/BA.4-5 booster was 50\u00b76% (95% CI 46\u00b70-54\u00b78) in the overall time interval 14-118 days post-administration. Overall, rVE was 49\u00b73% (43\u00b76-54\u00b74) for the bivalent original/BA.1 booster and 26\u00b79% (11\u00b78-39\u00b73) for the monovalent booster. For the bivalent original/BA.4-5 booster, we did not observe relevant differences in rVE between the 60-79-year age group (overall, 53\u00b76%; 46\u00b78-59\u00b75) and those aged 80 years or older (overall, 48\u00b73%; 41\u00b79-54\u00b70).\r\n\r\nThese findings suggest that a second booster with mRNA vaccines provides additional protection against severe COVID-19 due to omicron BA.5 (the predominant circulating subvariant in Italy during the study period) in people aged 60 years or older. Although rVE decreased over time, a second booster with the original/BA.4-5 mRNA vaccine, currently the most used in Italy, was found to be still providing protection 4 months post-administration.\r\n\r\nNextGenerationEU-MUR-PNRR Extended Partnership initiative on Emerging Infectious Diseases (project number PE00000007, INF-ACT).\r\n\r\nFor the Italian translation of the abstract see Supplementary Materials section.", "doi": "10.1016/S1473-3099(23)00374-2", "pmid": "37478877", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(23)00374-2"}], "notes": [], "created": "2023-10-04T12:08:12.943Z", "modified": "2023-10-04T12:30:26.922Z"}, {"entity": "publication", "iuid": "a06d396df52745dfb22dc30368de75ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a06d396df52745dfb22dc30368de75ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a06d396df52745dfb22dc30368de75ef"}}, "title": "Practices of Care in Participatory Design With Older Adults During the COVID-19 Pandemic: Digitally Mediated Study.", "authors": [{"family": "Paluch", "given": "Richard", "initials": "R", "orcid": "0000-0003-0420-7028", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50123f4f07fd4f9bac7aec9cfaaa4618.json"}}, {"family": "Cerna", "given": "Katerina", "initials": "K", "orcid": "0000-0001-8796-343X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31750b30f1584f33abd4e31d8fac84a2.json"}}, {"family": "Kirschsieper", "given": "Dennis", "initials": "D", "orcid": "0009-0000-9081-0418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e3bc92c91af411eb29cfbb736e98389.json"}}, {"family": "M\u00fcller", "given": "Claudia", "initials": "C", "orcid": "0000-0001-8534-546X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06fab12a9dd148a3b68fc7f2524d5272.json"}}], "type": "journal article", "published": "2023-07-17", "journal": {"title": "J Med Internet Res", "issn": "1438-8871", "issn-l": null, "volume": "25", "issue": null, "pages": "e45750"}, "abstract": "Participatory Design (PD), albeit an established approach in User-Centered Design, comes with specific challenges when working with older adults as research participants. Addressing these challenges relates to the reflection and negotiation of the positionalities of the researchers and research participants and includes various acts of giving and receiving help. During the COVID-19 pandemic, facets of positionalities and (mutual) care became particularly evident in qualitative and participatory research settings.\r\n\r\nThe aim of this paper was to systematically analyze care practices of participatory (design) research, which are to different extents practices of the latter. Using a multiyear PD project with older people that had to take place remotely over many months, we specify different practices of care; how they relate to collaborative work in the design project; and represent foundational practices for sustainable, long-term co-design. Our research questions were \"How can digitally-mediated PD work during COVID-19 and can we understand such digital PD as 'care'?\"\r\n\r\nOur data comes from the Joint Programming Initiative \"More Years, Better Lives\" (JPI MYBL), a European Union project that aims to promote digital literacy and technology appropriation among older adults in domestic settings. It targeted the cocreation, by older adults and university researchers, of a mobile demo kit website with cocreated resources, aimed at improving the understanding of use options of digital tools. Through a series of workshops, a range of current IT products was explored by a group of 21 older adults, which served as the basis for joint cocreative work on generating design ideas and prototypes. We reflect on the PD process and examine how the actors enact and manifest care.\r\n\r\nThe use of digital technology allowed the participatory project to continue during the COVID-19 pandemic and accentuated the digital skills of older adults and the improvement of digital literacy as part of \"care.\" We provide empirically based evidence of PD with older adults developing digital literacy and sensitizing concepts, based on the notion of care by Tronto for differentiating aspects and processes of care. The data suggest that it is not enough to focus solely on the technologies and how they are used; it is also necessary to focus on the social structures in which help is available and in which technologies offer opportunities to do care work.\r\n\r\nWe document that the cocreation of different digital media tools can be used to provide a community with mutual care. Our study demonstrates how research participants effectively enact different forms of care and how such \"care\" is a necessary basis for a genuinely participatory approach, which became especially meaningful as a form of support during COVID-19. We reflect on how notions of \"care\" and \"caring\" that were central to the pandemic response are also central to PD.", "doi": "10.2196/45750", "pmid": "37459177", "labels": {"Category: Health": null, "Type: Journal article": null, "Funder: H2020": null}, "xrefs": [{"db": "pmc", "key": "PMC10390970"}, {"db": "pii", "key": "v25i1e45750"}], "notes": [], "created": "2023-10-04T12:09:48.554Z", "modified": "2023-10-04T13:02:21.842Z"}, {"entity": "publication", "iuid": "a6a1b3cc2625453bb09de11b4df67c4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6a1b3cc2625453bb09de11b4df67c4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6a1b3cc2625453bb09de11b4df67c4d"}}, "title": "Comparing severe COVID-19 outcomes of first and second/third waves: a prospective single-centre cohort study of health-related quality of life and pulmonary outcomes 6 months after infection.", "authors": [{"family": "Darlington", "given": "Pernilla", "initials": "P", "orcid": "0000-0002-3411-8838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ded6431af104890a284d0cd458bd8d4.json"}}, {"family": "Ro\u00ebl", "given": "Mari", "initials": "M"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Hanna", "given": "Gabriel", "initials": "G"}, {"family": "Hedman", "given": "Anders", "initials": "A"}, {"family": "Joelsson-Alm", "given": "Eva", "initials": "E"}, {"family": "Schandl", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2023-07-17", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "7", "pages": "e071394"}, "abstract": "We aimed to compare long-term outcomes in intensive care unit (ICU) survivors between the first and second/third waves of the COVID-19 pandemic. More specifically, to assess health-related quality of life (HRQL) and respiratory health 6 months post-ICU and to study potential associations between patient characteristic and treatment variables regarding 6-month outcomes.\r\n\r\nProspective cohort study.\r\n\r\nSingle-centre study of adult COVID-19 patients with respiratory distress admitted to two Swedish ICUs during the first wave (1 March 2020-1 September 2020) and second/third waves (2 September 2020- 1 August 2021) with follow-up approximately 6 months after ICU discharge.\r\n\r\nCritically ill COVID-19 patients who survived for at least 90 days.\r\n\r\nHRQL, extent of residual changes on chest CT scan and pulmonary function were compared between the waves. General linear regression and multivariable logistic regression were used to present mean score differences (MSD) and ORs with 95% CIs.\r\n\r\nOf the 456 (67%) critically ill COVID-19 patients who survived at least 90 days, 278 (61%) were included in the study. Six months after ICU discharge, HRQL was similar between survivors in the pandemic waves, except that the second/third wave survivors had better role physical (MSD 20.2, 95% CI 7.3 to 33.1, p<0.01) and general health (MSD 7.2, 95% CI 0.7 to 13.6, p=0.03) and less bodily pain (MSD 12.2, 95% CI 3.6 to 20.8, p<0.01), while first wave survivors had better diffusing capacity of the lungs for carbon monoxide (OR 1.9, 95% CI 1.1 to 3.5, p=0.03).\r\n\r\nThis study indicates that even though intensive care treatment strategies have changed with time, there are few differences in long-term HRQL and respiratory health seems to remain at 6 months for patients surviving critical COVID-19 in the first and second/third waves of the pandemic.", "doi": "10.1136/bmjopen-2022-071394", "pmid": "37460259", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10357304"}, {"db": "pii", "key": "bmjopen-2022-071394"}], "notes": [], "created": "2023-10-04T12:09:03.426Z", "modified": "2023-10-04T12:48:03.979Z"}, {"entity": "publication", "iuid": "66216a329eff46a9a193603cec068305", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66216a329eff46a9a193603cec068305.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66216a329eff46a9a193603cec068305"}}, "title": "Organised crisis volunteers, COVID-19, and the political steering of crisis management in Sweden.", "authors": [{"family": "Wimelius", "given": "Malin E", "initials": "ME"}, {"family": "Strandh", "given": "Veronica", "initials": "V"}], "type": "journal article", "published": "2023-07-14", "journal": {"title": "Disasters", "issn": "1467-7717", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "This paper explores and analyses the activities of Swedish organised crisis volunteers during the COVID-19 pandemic. Based on a questionnaire and interviews, it sets out to answer two research questions on what characterised organised volunteerism during the pandemic, how organised volunteers experienced cooperation with local public actors, and how they viewed political steering. The paper contributes to a growing literature on the role of volunteers and links that role to views on political steering, something that is rarely done in disaster research. Sweden is a useful case study because of how COVID-19 was managed, as well as because there are organised crisis volunteers and a debate is occurring on how the national system is steered. The paper shows how organised volunteers adapted to changing needs and adopted new roles, that experiences of cooperation with local authorities varied, and that calls were made for a stronger national leadership and for more explicit central political steering.", "doi": "10.1111/disa.12604", "pmid": "37450584", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:09:22.610Z", "modified": "2023-10-04T12:51:45.561Z"}, {"entity": "publication", "iuid": "02e7c304712a42c0a4343afa18dbbaf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02e7c304712a42c0a4343afa18dbbaf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02e7c304712a42c0a4343afa18dbbaf3"}}, "title": "Effect of the COVID-19 pandemic on emergency department attendances for pediatric injuries in Mozambique's central hospitals: an interrupted time series and a comparison within the restriction periods between 2019 and 2020.", "authors": [{"family": "Amado", "given": "Vanda", "initials": "V", "orcid": "0000-0002-8839-984X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e564fcb429b45c8932476d0df8d086f.json"}}, {"family": "Moller", "given": "Jette", "initials": "J"}, {"family": "Couto", "given": "Maria Tereza", "initials": "MT"}, {"family": "Wallis", "given": "Lee", "initials": "L"}, {"family": "Laflamme", "given": "Lucie", "initials": "L"}], "type": "journal article", "published": "2023-07-14", "journal": {"title": "Trauma Surg Acute Care Open", "issn": "2397-5776", "issn-l": null, "volume": "8", "issue": "1", "pages": "e001062"}, "abstract": "Hospital-based studies indicate that restriction measures imposed during the COVID-19 pandemic have affected the number and characteristics of pediatric injuries. However, few studies have been conducted in resource-poor countries. This study aimed to determine whether injury-related emergency department (ED) attendances in Mozambique were affected during the restriction periods in 2020 and how the pattern of injury changed.\r\n\r\nMozambique faced two restriction periods in 2020. An interrupted time series was applied to weekly data of pediatric injuries from the ED records of four central hospitals in Mozambique in 2019 and 2020. Weekly numbers of injuries were modeled using a Poisson regression model to estimate the effect of COVID-19 restrictions on trends over calendar time. Then, for each restriction period, differences in injury mechanisms, severity, need for surgery, and intensive care unit (ICU) attendances were compared between 2019 and 2020.\r\n\r\nDuring the 76 weeks preceding the restrictions, there was a stable trend in ED attendances. The weekly number dropped by 48.7% after implementation of the first restrictions. By the end of 2020, the weekly numbers were back to the levels observed before the restrictions. Road traffic injuries (RTIs) and falls dropped during the first restriction period and RTIs and burns during the second. There was an increase of 80% in ICU attendances in all periods of 2020 at three hospitals during the first and second restriction periods.\r\n\r\nThe COVID-19 restrictions yielded a reduction in the weekly number of pediatric injuries seen at Mozambique's central hospitals, above all RTIs and falls. The drop reflects reductions in visits most importantly for RTIs, falls, and burns, but was accompanied by an increase in the proportion of ICU cases. This effect was not maintained when the restrictions were relaxed. Whether this reflects reduced exposure to injury or hesitancy to seek care remains to be determined.\r\n\r\nLevel III, retrospective study with up to two negative criteria.", "doi": "10.1136/tsaco-2022-001062", "pmid": "37484836", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10350904"}, {"db": "pii", "key": "tsaco-2022-001062"}], "notes": [], "created": "2023-10-04T12:10:28.808Z", "modified": "2023-10-04T13:14:11.870Z"}, {"entity": "publication", "iuid": "5711df6665da4420973aa4d6e5d0592e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5711df6665da4420973aa4d6e5d0592e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5711df6665da4420973aa4d6e5d0592e"}}, "title": "The influence of COVID-19 risk perception and vaccination status on the number of social contacts across Europe: insights from the CoMix study.", "authors": [{"family": "Wambua", "given": "James", "initials": "J"}, {"family": "Loedy", "given": "Neilshan", "initials": "N"}, {"family": "Jarvis", "given": "Christopher I", "initials": "CI"}, {"family": "Wong", "given": "Kerry L M", "initials": "KLM"}, {"family": "Faes", "given": "Christel", "initials": "C"}, {"family": "Grah", "given": "Rok", "initials": "R"}, {"family": "Prasse", "given": "Bastian", "initials": "B"}, {"family": "Sandmann", "given": "Frank", "initials": "F"}, {"family": "Niehus", "given": "Rene", "initials": "R"}, {"family": "Johnson", "given": "Helen", "initials": "H"}, {"family": "Edmunds", "given": "W John", "initials": "WJ"}, {"family": "Beutels", "given": "Philippe", "initials": "P"}, {"family": "Hens", "given": "Niel", "initials": "N"}, {"family": "Coletti", "given": "Pietro", "initials": "P"}], "type": "journal article", "published": "2023-07-13", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "23", "issue": "1", "pages": "1350"}, "abstract": "The SARS-CoV-2 transmission dynamics have been greatly modulated by human contact behaviour. To curb the spread of the virus, global efforts focused on implementing both Non-Pharmaceutical Interventions (NPIs) and pharmaceutical interventions such as vaccination. This study was conducted to explore the influence of COVID-19 vaccination status and risk perceptions related to SARS-CoV-2 on the number of social contacts of individuals in 16 European countries.\r\n\r\nWe used data from longitudinal surveys conducted in the 16 European countries to measure social contact behaviour in the course of the pandemic. The data consisted of representative panels of participants in terms of gender, age and region of residence in each country. The surveys were conducted in several rounds between December 2020 and September 2021 and comprised of 29,292 participants providing a total of 111,103 completed surveys. We employed a multilevel generalized linear mixed effects model to explore the influence of risk perceptions and COVID-19 vaccination status on the number of social contacts of individuals.\r\n\r\nThe results indicated that perceived severity played a significant role in social contact behaviour during the pandemic after controlling for other variables (p-value < 0.001). More specifically, participants who had low or neutral levels of perceived severity reported 1.25 (95% Confidence intervals (CI) 1.13 - 1.37) and 1.10 (95% CI 1.00 - 1.21) times more contacts compared to those who perceived COVID-19 to be a serious illness, respectively. Additionally, vaccination status was also a significant predictor of contacts (p-value < 0.001), with vaccinated individuals reporting 1.31 (95% CI 1.23 - 1.39) times higher number of contacts than the non-vaccinated. Furthermore, individual-level factors played a more substantial role in influencing contact behaviour than country-level factors.\r\n\r\nOur multi-country study yields significant insights on the importance of risk perceptions and vaccination in behavioral changes during a pandemic emergency. The apparent increase in social contact behaviour following vaccination would require urgent intervention in the event of emergence of an immune escaping variant.", "doi": "10.1186/s12889-023-16252-z", "pmid": "37442987", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Social Science & Humanities": null, "Funder: H2020": null}, "xrefs": [{"db": "pmc", "key": "PMC10347859"}, {"db": "pii", "key": "10.1186/s12889-023-16252-z"}], "notes": [], "created": "2023-10-04T12:08:18.368Z", "modified": "2023-10-04T12:32:22.312Z"}, {"entity": "publication", "iuid": "8ecaa819bcdc4d49b92adfe225613ff0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ecaa819bcdc4d49b92adfe225613ff0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ecaa819bcdc4d49b92adfe225613ff0"}}, "title": "Individual-level precision diagnosis for coronavirus disease 2019 related severe outcome: an early study in New York.", "authors": [{"family": "Huang", "given": "Chaorui C", "initials": "CC"}, {"family": "Xu", "given": "Hong", "initials": "H"}], "type": "journal article", "published": "2023-07-13", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "11317"}, "abstract": "Because of inadequate information provided by the on-going population level risk analyses for Coronavirus disease 2019 (COVID-19), this study aimed to evaluate the risk factors and develop an individual-level precision diagnostic method for COVID-19 related severe outcome in New York State (NYS) to facilitate early intervention and predict resource needs for patients with COVID-19. We analyzed COVID-19 related hospital encounter and hospitalization in NYS using Statewide Planning and Research Cooperative System hospital discharge dataset. Logistic regression was performed to evaluate the risk factors for COVID-19 related mortality. We proposed an individual-level precision diagnostic method by taking into consideration of the different weights and interactions of multiple risk factors. Age was the greatest risk factor for COVID-19 related fatal outcome. By adding other demographic variables, dyspnea or hypoxemia and multiple chronic co-morbid conditions, the model predictive accuracy was improved to 0.85 (95% CI 0.84-0.85). We selected cut-off points for predictors and provided a general recommendation to categorize the levels of risk for COVID-19 related fatal outcome, which can facilitate the individual-level diagnosis and treatment, as well as medical resource prediction. We further provided a use case of our method to evaluate the feasibility of public health policy for monoclonal antibody therapy.", "doi": "10.1038/s41598-023-35966-z", "pmid": "37443363", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10344938"}, {"db": "pii", "key": "10.1038/s41598-023-35966-z"}], "notes": [], "created": "2023-10-04T12:08:20.888Z", "modified": "2023-10-04T12:33:28.301Z"}, {"entity": "publication", "iuid": "0a3a113ae8d94215aa2d5d077722c049", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a3a113ae8d94215aa2d5d077722c049.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a3a113ae8d94215aa2d5d077722c049"}}, "title": "Post COVID-19 symptoms are common, also among young adults in the general population.", "authors": [{"family": "Mogensen", "given": "Ida", "initials": "I"}, {"family": "Ekstr\u00f6m", "given": "Sandra", "initials": "S"}, {"family": "Hallberg", "given": "Jenny", "initials": "J"}, {"family": "Georgelis", "given": "Antonios", "initials": "A"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Bergstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Kull", "given": "Inger", "initials": "I"}], "type": "journal article", "published": "2023-07-12", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "13", "issue": "1", "pages": "11300"}, "abstract": "Post coronavirus disease-19 (post COVID-19) is mainly studied in clinical populations and less is known about post COVID-19 in a young general population. The aim of the study is to investigate the prevalence and symptoms of post COVID-19 and its potential risk factors in young adults. Participants from the Swedish population-based birth cohort BAMSE were included (n = 2022, mean age 26.5 years). Post COVID-19 was assessed through a questionnaire and defined as symptoms after confirmed COVID-19 (registry-based or self-reported positive test) lasting for \u2265 2 months. In total, 681 participants had had confirmed COVID-19. Among them, 112 (16.5%) fulfilled the definition of post COVID-19 (17.8% in females, 14.5% in males, p = 0.26). The most common post COVID-19 symptoms were altered smell and taste (68.8%), dyspnea (33.7%) and fatigue (30.4%). Overall, no major risk factors for post COVID-19 were identified except for being bedbound during COVID-19. However, asthma and rhinitis were associated with the post COVID-19 symptom dyspnea, migraine with altered smell and taste, and lower self-rated health with fatigue. In conclusion, post COVID-19 symptoms are common, also among young adults in the general population. Although not life-threatening, it could have a considerable impact on public health due to the high prevalence and long-term symptoms.", "doi": "10.1038/s41598-023-38315-2", "pmid": "37438424", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC10338459"}, {"db": "pii", "key": "10.1038/s41598-023-38315-2"}], "notes": [], "created": "2023-07-13T11:31:58.051Z", "modified": "2023-10-04T12:29:26.665Z"}, {"entity": "publication", "iuid": "24523286d51a489ab3267bcf49c947b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24523286d51a489ab3267bcf49c947b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24523286d51a489ab3267bcf49c947b4"}}, "title": "Lessons from COVID-19 for Pandemic Preparedness: Proceedings from a Multi-Stakeholder Think Tank.", "authors": [{"family": "Narayanasamy", "given": "Shanti", "initials": "S", "orcid": "0000-0002-6667-2868", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53cc5ca9db8d49678370dbaad3d91ac0.json"}}, {"family": "Curtis", "given": "Lesley H", "initials": "LH"}, {"family": "Hernandez", "given": "Adrian F", "initials": "AF"}, {"family": "Woods", "given": "Christopher W", "initials": "CW"}, {"family": "Moody", "given": "M Anthony", "initials": "MA"}, {"family": "Sulkowski", "given": "Mark", "initials": "M"}, {"family": "Turbett", "given": "Sarah E", "initials": "SE"}, {"family": "Baden", "given": "Lindsey R", "initials": "LR"}, {"family": "Gulick", "given": "Roy M", "initials": "RM"}, {"family": "Pau", "given": "Alice K", "initials": "AK"}, {"family": "Adam", "given": "Stacey J", "initials": "SJ"}, {"family": "Marks", "given": "Peter", "initials": "P"}, {"family": "Stockbridge", "given": "Norman L", "initials": "NL"}, {"family": "Dobbins", "given": "John R", "initials": "JR"}, {"family": "Krofah", "given": "Esther", "initials": "E"}, {"family": "Leav", "given": "Brett", "initials": "B"}, {"family": "Pang", "given": "Phil", "initials": "P"}, {"family": "Roessig", "given": "Lothar", "initials": "L"}, {"family": "Vedin", "given": "Ola", "initials": "O"}, {"family": "Waldstreicher", "given": "Joanne", "initials": "J"}, {"family": "Berman", "given": "Stacey Cromer", "initials": "SC"}, {"family": "Cremisi", "given": "Henry", "initials": "H"}, {"family": "Schofield", "given": "Lesley", "initials": "L"}, {"family": "Gandhi", "given": "Rajesh T", "initials": "RT"}, {"family": "Naggie", "given": "Susanna", "initials": "S"}], "type": "journal article", "published": "2023-07-12", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "issn-l": "1058-4838", "volume": null, "issue": null, "pages": null}, "abstract": "While the Coronavirus Disease 2019 (COVID-19) pandemic continues to present global challenges, sufficient time has passed to reflect on lessons learned and use those insights to inform policy and approaches to prepare for the next pandemic. In May 2022, the Duke Clinical Research Institute (DCRI) convened a Think Tank with thought-leaders from academia, clinical practice, the pharmaceutical industry, patient advocacy, the National Institutes of Health, the US Food and Drug Administration (FDA), and Centers for Disease Control and Prevention (CDC), to share firsthand, expert knowledge of the insights gained from the COVID-19 pandemic and how this acquired knowledge can help inform the next pandemic response. The Think Tank focused on pandemic preparedness, therapeutics, vaccines, and challenges related to clinical trial design and scale-up during the early phase of a pandemic. Based on the multi-faceted discussions, we outline ten key steps to an improved and equitable pandemic response.", "doi": "10.1093/cid/ciad418", "pmid": "37435958", "labels": {"Category: Other": null, "Type: Other": null}, "xrefs": [{"db": "pii", "key": "7223127"}], "notes": [], "created": "2023-10-04T12:10:24.038Z", "modified": "2023-10-04T13:12:14.203Z"}, {"entity": "publication", "iuid": "f0eee6262116469689fc2cacd6e9a821", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f0eee6262116469689fc2cacd6e9a821.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f0eee6262116469689fc2cacd6e9a821"}}, "title": "Additive effects of booster mRNA vaccination and SARS-CoV-2 Omicron infection on T cell immunity across immunocompromised states.", "authors": [{"family": "M\u00fcller", "given": "Thomas R", "initials": "TR", "orcid": "0000-0001-5331-5522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28e705f82ca64e698015b577d25e991c.json"}}, {"family": "Sekine", "given": "Takuya", "initials": "T", "orcid": "0000-0001-7649-0593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a234e0d77c145aa8d23b89fde1c5883.json"}}, {"family": "Trubach", "given": "Darya", "initials": "D", "orcid": "0009-0005-7445-9281", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09dcd62967fe432bbc292f3a10f0458d.json"}}, {"family": "Niessl", "given": "Julia", "initials": "J", "orcid": "0000-0001-8852-1924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70aba42c7f0b400eba1a226ee193d9fd.json"}}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Bergman", "given": "Peter", "initials": "P", "orcid": "0000-0003-3306-3713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15b7290255814a7b9a1a97c3cdb2fc26.json"}}, {"family": "Blennow", "given": "Ola", "initials": "O", "orcid": "0000-0002-7167-7882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2318c3973e66443aa14fceca0908d127.json"}}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Mielke", "given": "Stephan", "initials": "S", "orcid": "0000-0002-8325-9215", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6f17a7cc4774614a3ad5ea9c910d75a.json"}}, {"family": "Nowak", "given": "Piotr", "initials": "P", "orcid": "0000-0003-2747-0734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1d81fdccf9e424fa99ea5227b031843.json"}}, {"family": "Vesterbacka", "given": "Jan", "initials": "J"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Olofsson", "given": "Anna", "initials": "A", "orcid": "0000-0002-7479-315X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b3cfdb6d9cc47e2ad2377d5fe51ca4a.json"}}, {"family": "Amaya Hernandez", "given": "Susana Patricia", "initials": "SP", "orcid": "0000-0003-4425-8145", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a28fef26f85d42d88cea8ea68ba0c7d0.json"}}, {"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Cai", "given": "Curtis", "initials": "C", "orcid": "0000-0002-3490-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52ab789751014f46b6b995a1cdef57a3.json"}}, {"family": "S\u00f6derdahl", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-4423-2458", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e23b3e831934cd786a15cb2183e810e.json"}}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE", "orcid": "0000-0003-1907-3392", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26a3bf24bd044fbda8ffa0c89974bdfe.json"}}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K", "orcid": "0000-0001-7679-9494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02d4d3d9ccc547f7ab18ba69493f6a34.json"}}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M", "orcid": "0000-0002-3793-4064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4bc179656eb442f9ac9dc72c8c6841d.json"}}, {"family": "Ljungman", "given": "Per", "initials": "P", "orcid": "0000-0002-8281-3245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4546eb504184683ab712eee858ea9cb.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Karlsson", "given": "Annika C", "initials": "AC", "orcid": "0000-0002-2028-8393", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9abf28110888427497db1e4abf6ff71d.json"}}, {"family": "Saini", "given": "Sunil Kumar", "initials": "SK", "orcid": "0000-0003-3382-9432", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ad140b13bdd4cd68cf422454b24c29f.json"}}, {"family": "Aleman", "given": "Soo", "initials": "S", "orcid": "0000-0003-0461-4870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b0edb2db8d840989936f67047ce91de.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}], "type": "journal article", "published": "2023-07-12", "journal": {"title": "Sci Transl Med", "issn": "1946-6242", "issn-l": null, "volume": "15", "issue": "704", "pages": "eadg9452"}, "abstract": "Suboptimal immunity to SARS-CoV-2 mRNA vaccination has frequently been observed in individuals with various immunodeficiencies. Given the increased antibody evasion properties of emerging SARS-CoV-2 subvariants, it is necessary to assess whether other components of adaptive immunity generate resilient and protective responses against infection. We assessed T cell responses in 279 individuals, covering five different immunodeficiencies and healthy controls, before and after booster mRNA vaccination, as well as after Omicron infection in a subset of patients. We observed robust and persistent Omicron-reactive T cell responses that increased markedly upon booster vaccination and correlated directly with antibody titers across all patient groups. Poor vaccination responsiveness in immunocompromised or elderly individuals was effectively counteracted by the administration of additional vaccine doses. Functionally, Omicron-reactive T cell responses exhibited a pronounced cytotoxic profile and signs of longevity, characterized by CD45RA+ effector memory subpopulations with stem cell-like properties and increased proliferative capacity. Regardless of underlying immunodeficiency, booster-vaccinated and Omicron-infected individuals appeared protected against severe disease and exhibited enhanced and diversified T cell responses against conserved and Omicron-specific epitopes. Our findings indicate that T cells retain the ability to generate highly functional responses against newly emerging variants, even after repeated antigen exposure and a robust immunological imprint from ancestral SARS-CoV-2 mRNA vaccination.", "doi": "10.1126/scitranslmed.adg9452", "pmid": "37437015", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-07-13T11:33:29.721Z", "modified": "2023-10-04T13:10:33.441Z"}, {"entity": "publication", "iuid": "a76734b17d444d2197424cfb38e73d84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a76734b17d444d2197424cfb38e73d84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a76734b17d444d2197424cfb38e73d84"}}, "title": "A design strategy to generate a SARS-CoV-2 RBD vaccine that abrogates ACE2 binding and improves neutralizing antibody responses.", "authors": [{"family": "Ratswohl", "given": "Christoph", "initials": "C", "orcid": "0000-0001-5413-0730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3c10f6df613450abcf5f5bf55a7b781.json"}}, {"family": "V\u00e1zquez Garc\u00eda", "given": "Clara", "initials": "C", "orcid": "0000-0003-4583-7616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/622a5e04069f4e0baedf9c4a21fed629.json"}}, {"family": "Ahmad", "given": "Ata Ul Wakeel", "initials": "AUW", "orcid": "0009-0003-0734-7904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/699b0a9abd014f9b923b0fd1392c9fd2.json"}}, {"family": "Gonschior", "given": "Hannes", "initials": "H", "orcid": "0000-0002-1775-8120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c36380bcaae467aba65ee13d7b0ffac.json"}}, {"family": "Lebedin", "given": "Mikhail", "initials": "M", "orcid": "0000-0002-3877-7195", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c19b8f990f2415aa1646e45343d082d.json"}}, {"family": "Silvis", "given": "Casper Ewijn", "initials": "CE", "orcid": "0009-0005-0433-2197", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee84cb3452784753b662fae0c62e6879.json"}}, {"family": "Spatt", "given": "Lisa", "initials": "L"}, {"family": "Gerhard", "given": "Cathrin", "initials": "C"}, {"family": "Lehmann", "given": "Martin", "initials": "M", "orcid": "0000-0002-8370-6353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ed100612ee3422f97d023858f63405d.json"}}, {"family": "Sander", "given": "Leif E", "initials": "LE", "orcid": "0000-0002-0476-9947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36c4c59d112a4a2dbdc313dcd69c9702.json"}}, {"family": "Kurth", "given": "Florian", "initials": "F", "orcid": "0000-0002-3807-473X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32dfbcb28c674000bb43fefe2938c711.json"}}, {"family": "Olsson", "given": "Simon", "initials": "S", "orcid": "0000-0002-3927-7897", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b6b2b0004ffe46ef8ba4181876a55762.json"}}, {"family": "de la Rosa", "given": "Kathrin", "initials": "K", "orcid": "0000-0003-4809-3157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee415ff0f17846ed8a136217a243409a.json"}}], "type": "journal article", "published": "2023-07-12", "journal": {"title": "Eur J Immunol", "issn": "1521-4141", "issn-l": null, "volume": null, "issue": null, "pages": "e2350408"}, "abstract": "The structure-based design of antigens holds promise for developing vaccines with higher efficacy and improved safety profiles. We postulate that abrogation of host receptor interaction bears potential for the improvement of vaccines by preventing antigen-induced modification of receptor function as well as the displacement or masking of the immunogen. Antigen modifications may yet destroy epitopes crucial for antibody neutralization. Here, we present a methodology that integrates deep mutational scans to identify and score SARS-CoV-2 receptor binding domain variants that maintain immunogenicity, but lack interaction with the widely expressed host receptor. Single point mutations were scored in silico, validated in vitro, and applied in vivo. Our top-scoring variant receptor binding domain-G502E prevented spike-induced cell-to-cell fusion, receptor internalization, and improved neutralizing antibody responses by 3.3-fold in rabbit immunizations. We name our strategy BIBAX for body-inert, B-cell-activating vaccines, which in the future may be applied beyond SARS-CoV-2 for the improvement of vaccines by design.", "doi": "10.1002/eji.202350408", "pmid": "37435628", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:10:39.531Z", "modified": "2023-10-04T13:28:51.730Z"}, {"entity": "publication", "iuid": "0784cfd79da945169d97f806226c1339", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0784cfd79da945169d97f806226c1339.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0784cfd79da945169d97f806226c1339"}}, "title": "Results of the first nationwide cohort study of outcomes in dialysis and kidney transplant patients before and after vaccination for COVID-19.", "authors": [{"family": "Wijkstr\u00f6m", "given": "Julia", "initials": "J", "orcid": "0000-0001-6183-5878", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c90a939ef95648a5812cda3a5769ca78.json"}}, {"family": "Caldinelli", "given": "Aurora", "initials": "A"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A", "orcid": "0000-0002-9752-9941", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86a352b1ff85430daf1cebd1c210d38b.json"}}, {"family": "Nowak", "given": "Alexandra", "initials": "A"}, {"family": "Artborg", "given": "Angelica", "initials": "A"}, {"family": "Stendahl", "given": "Maria", "initials": "M"}, {"family": "Segelmark", "given": "M\u00e5rten", "initials": "M", "orcid": "0000-0002-1221-0772", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39ab2e6d40d441389c037b936eaac574.json"}}, {"family": "Lindholm", "given": "Bengt", "initials": "B"}, {"family": "Bellocco", "given": "Rino", "initials": "R"}, {"family": "Rydell", "given": "Helena", "initials": "H"}, {"family": "Evans", "given": "Marie", "initials": "M", "orcid": "0000-0001-8650-5795", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adad70f1421b4ae49c160017cfba58a1.json"}}], "type": "journal article", "published": "2023-07-11", "journal": {"title": "Nephrol Dial Transplant", "issn": "1460-2385", "issn-l": "0931-0509", "volume": null, "issue": null, "pages": null}, "abstract": "Patients with kidney replacement therapy (KRT) have been identified as a vulnerable group during the COVID-19 pandemic. This study reports the outcomes of COVID-19 in KRT patients in Sweden, a country where patients on KRT were prioritized early in the vaccination campaign.\r\n\r\nPatients with KRT between January 2019 and December 2021 in the Swedish Renal Registry were included. Data were linked to national healthcare registries. The primary outcome was monthly all-cause mortality over three-years follow-up. The secondary outcomes were monthly COVID-19 related deaths and hospitalizations. The results were compared with the general population using standardized mortality ratios. The difference in risk for COVID-19 related outcomes between dialysis and kidney transplant recipients was assessed in multivariable logistic regression models before and after vaccinations started.\r\n\r\nOn January 1, 2020, there were 4097 patients on dialysis (median age 70) and 5905 kidney transplant recipients (median age 58). Between March 2020 and February 2021, mean all-cause mortality rates increased by 10% (from 720 to 804 deaths) and 22% (from 158 to 206 deaths) in dialysis and kidney transplant recipients respectively compared with the same period 2019. After vaccinations started, all-cause mortality rates during the third wave (April 2021) returned to pre COVID-19 mortality rates among dialysis patients, while mortality rates remained increased among transplant recipients. Dialysis patients had a higher risk for COVID-19 hospitalizations and death before vaccinations started aOR 2.1 (95% CI 1.7-2.5), but a lower risk after vaccination, aOR 0.5 (95% CI 0.4-0.7) compared to kidney transplant recipients.\r\n\r\nThe COVID-19 pandemic in Sweden resulted in increased mortality and hospitalization rates among KRT patients. After vaccinations started, a distinct reduction in hospitalization and mortality rates was observed among dialysis patients, but not in kidney transplant recipients. Early and prioritized vaccinations of KRT patients in Sweden probably saved many lives.", "doi": "10.1093/ndt/gfad151", "pmid": "37433606", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "7222920"}], "notes": [], "created": "2023-10-04T12:08:47.555Z", "modified": "2023-10-04T12:40:55.746Z"}, {"entity": "publication", "iuid": "d70c893e2e234b7887b2b8d5b290ecd4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d70c893e2e234b7887b2b8d5b290ecd4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d70c893e2e234b7887b2b8d5b290ecd4"}}, "title": "Predictors of Sustained Physical Activity During the COVID-19 Pandemic in People With Parkinson Disease in Sweden.", "authors": [{"family": "Moulaee Conradsson", "given": "David", "initials": "D"}, {"family": "Leavy", "given": "Breiffni", "initials": "B"}, {"family": "Hagstr\u00f6mer", "given": "Maria", "initials": "M"}, {"family": "Franz\u00e9n", "given": "Erika", "initials": "E"}], "type": "journal article", "published": "2023-07-10", "journal": {"title": "J Neurol Phys Ther", "issn": "1557-0584", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "During the first wave of the COVID-19 pandemic, people with Parkinson disease (PwPD) reported deterioration in health and physical activity. The aim of this study was to describe 1-year changes in physical activity and perceived health in PwPD during the COVID-19 pandemic and to identify predictors of sustained physical activity.\r\n\r\nThis study compared perceived health and sensor-derived physical activity (Actigraph GT3x) in PwPD between the first (June to July 2020) and third waves (June to July 2021) of the pandemic. Multiple logistic regression analyses were used to predict sustained physical activity across the study period using personal factors, disease severity, and functioning as independent variables.\r\n\r\nSixty-three PwPD (mean age 71.0 years, 41% females) completed both baseline and 1-year follow-up (26 lost to follow-up). PwPD showed a decrease in average number of steps per day (\u0394415 steps, P = 0.048), moderate-to-vigorous-physical activity (\u03947 minutes, P = 0.007) and increase in sedentary time (\u039436 minutes, P <.001) between baseline and 1-year follow-up. While self-perceived walking impairments and depressive symptoms increased significantly, balance confidence decreased between baseline and 1-year follow-up, no significant changes occurred for self-rated health, quality of life, or anxiety. Significant predictors of sustained physical activity levels were 15 years or more of education (odds ratio [OR] = 7.38, P = 0.013) and higher perceived walking ability (OR = 0.18, P = 0.041).\r\n\r\nAmong PwPD with mild to moderate disease severity living in Sweden, factors associated with reduced physical activity levels during the COVID-19 pandemic included older age, lower education levels, and greater perceived walking difficulties.Video Abstract available for more insights from the authors (see the Video, the Supplemental Digital Content, available at: http://links.lww.com/JNPT/A451).", "doi": "10.1097/NPT.0000000000000455", "pmid": "37436217", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "01253086-990000000-00045"}], "notes": [], "created": "2023-10-04T12:09:30.076Z", "modified": "2023-10-04T12:54:56.989Z"}, {"entity": "publication", "iuid": "464dfd70bfc3466082fd3a71ab1be22c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/464dfd70bfc3466082fd3a71ab1be22c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/464dfd70bfc3466082fd3a71ab1be22c"}}, "title": "MEDIATE - Molecular DockIng at homE: Turning collaborative simulations into therapeutic solutions.", "authors": [{"family": "Vistoli", "given": "Giulio", "initials": "G"}, {"family": "Manelfi", "given": "Candida", "initials": "C"}, {"family": "Talarico", "given": "Carmine", "initials": "C"}, {"family": "Fava", "given": "Anna", "initials": "A"}, {"family": "Warshel", "given": "Arieh", "initials": "A"}, {"family": "Tetko", "given": "Igor V", "initials": "IV"}, {"family": "Apostolov", "given": "Rossen", "initials": "R"}, {"family": "Ye", "given": "Yang", "initials": "Y"}, {"family": "Latini", "given": "Chiara", "initials": "C"}, {"family": "Ficarelli", "given": "Federico", "initials": "F"}, {"family": "Palermo", "given": "Gianluca", "initials": "G", "orcid": "0000-0001-7955-8012", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c8395c9ce314613b2fca368fc49a2dd.json"}}, {"family": "Gadioli", "given": "Davide", "initials": "D"}, {"family": "Vitali", "given": "Emanuele", "initials": "E"}, {"family": "Varriale", "given": "Gaetano", "initials": "G"}, {"family": "Pisapia", "given": "Vincenzo", "initials": "V"}, {"family": "Scaturro", "given": "Marco", "initials": "M"}, {"family": "Coletti", "given": "Silvano", "initials": "S"}, {"family": "Gregori", "given": "Daniele", "initials": "D"}, {"family": "Gruffat", "given": "Daniel", "initials": "D"}, {"family": "Leija", "given": "Edgardo", "initials": "E"}, {"family": "Hessenauer", "given": "Sam", "initials": "S"}, {"family": "Delbianco", "given": "Alberto", "initials": "A"}, {"family": "Allegretti", "given": "Marcello", "initials": "M"}, {"family": "Beccari", "given": "Andrea R", "initials": "AR"}], "type": "journal article", "published": "2023-07-10", "journal": {"title": "Expert Opin Drug Discov", "issn": "1746-045X", "issn-l": null, "volume": "18", "issue": "8", "pages": "821-833"}, "abstract": "Collaborative computing has attracted great interest in the possibility of joining the efforts of researchers worldwide. Its relevance has further increased during the pandemic crisis since it allows for the strengthening of scientific collaborations while avoiding physical interactions. Thus, the E4C consortium presents the MEDIATE initiative which invited researchers to contribute via their virtual screening simulations that will be combined with AI-based consensus approaches to provide robust and method-independent predictions. The best compounds will be tested, and the biological results will be shared with the scientific community.\r\n\r\nIn this paper, the MEDIATE initiative is described. This shares compounds' libraries and protein structures prepared to perform standardized virtual screenings. Preliminary analyses are also reported which provide encouraging results emphasizing the MEDIATE initiative's capacity to identify active compounds.\r\n\r\nStructure-based virtual screening is well-suited for collaborative projects provided that the participating researchers work on the same input file. Until now, such a strategy was rarely pursued and most initiatives in the field were organized as challenges. The MEDIATE platform is focused on SARS-CoV-2 targets but can be seen as a prototype which can be utilized to perform collaborative virtual screening campaigns in any therapeutic field by sharing the appropriate input files.", "doi": "10.1080/17460441.2023.2221025", "pmid": "37424369", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null, "Funder: H2020": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:12:49.893Z", "modified": "2023-10-04T13:35:51.361Z"}, {"entity": "publication", "iuid": "c4c830abc4d14a30afe060376ff608dc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c4c830abc4d14a30afe060376ff608dc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c4c830abc4d14a30afe060376ff608dc"}}, "title": "COVID-19 risk perception and public compliance with preventive measures: Evidence from a multi-wave household survey in the MENA region.", "authors": [{"family": "Abu Hatab", "given": "Assem", "initials": "A", "orcid": "0000-0002-6764-1887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/555972d8e62042e19e254cc81a9f3743.json"}}, {"family": "Krautscheid", "given": "Lena", "initials": "L"}, {"family": "Amuakwa-Mensah", "given": "Franklin", "initials": "F", "orcid": "0000-0002-3581-4704", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cb40adcc28c419f99e56a827b03ef74.json"}}], "type": "journal article", "published": "2023-07-10", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "7", "pages": "e0283412"}, "abstract": "This study investigates the association between individuals' concern about contracting COVID-19 and their compliance with recommended preventive and mitigation measures, namely wearing face masks, maintaining social distancing and handwashing, in the context of the Middle East and North Africa (MENA) region. The empirical analysis is based on a panel dataset from the Combined COVID-19 MENA Monitor Household Survey, which was carried out in Jordan, Morocco, Sudan, Tunisia and Egypt. Applying a probit estimation technique, a positive and statistically significant association was found between the level of COVID-19 worries and individuals' compliance with the mitigation measures. Notably, the results revealed that this association followed a \"first-up-then-down\" trend, showing that compliance with the three mitigation measures rose as individuals' worries about contracting the virus increased, and then markedly decreased after they had been infected. Socio-demographic characteristics contributing to lower levels of compliance included being male, being over 60, having lower levels of education and having a lower household income. A cross-country analysis revealed remarkable differences between the five countries, with the strongest association between COVID-19 concerns and adherence to mitigation measures observed in Tunisia and Sudan, and the weakest association seen in Jordan and Morocco. Policy implications are outlined for effective risk communication and management during disease outbreaks and public health emergencies to encourage appropriate public health behaviours.", "doi": "10.1371/journal.pone.0283412", "pmid": "37428731", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10332611"}, {"db": "pii", "key": "PONE-D-22-31846"}], "notes": [], "created": "2023-10-04T12:08:50.332Z", "modified": "2023-10-04T12:42:27.896Z"}, {"entity": "publication", "iuid": "a7d0e355c176491a894c755145aea491", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7d0e355c176491a894c755145aea491.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7d0e355c176491a894c755145aea491"}}, "title": "Sociodemographic disparities affect COVID-19 vaccine uptake in non-elderly adults with increased risk of severe COVID-19.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P", "orcid": "0000-0003-3153-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd6af5accfc84ff9a81983a5ab6683aa.json"}}, {"family": "Sotoodeh", "given": "Adonis", "initials": "A"}, {"family": "Askling", "given": "Helena H", "initials": "HH"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P", "orcid": "0000-0002-8185-2648", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78b415aee4864810b8ce8f1962fa288f.json"}}], "type": "journal article", "published": "2023-07-09", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "There is limited information about sociodemographic disparities in COVID-19 vaccine uptake among non-elderly adults with an increased risk of severe COVID-19. We investigated the COVID-19 vaccine uptake in individuals aged 18-64 years with an increased risk of severe COVID-19 (non-elderly risk group) in Stockholm County, Sweden.\r\n\r\nWe used population-based health and sociodemographic registries with high coverage to perform a cohort study of COVID-19 vaccine uptake of one to four doses up until 21 November 2022. The vaccine uptake in the non-elderly risk group was compared with non-risk groups aged 18-64 years (non-elderly non-risk group) and individuals aged \u226565 years (elderly).\r\n\r\nThe uptake of \u22653 vaccine doses was 55%, 64% and 87% in the non-elderly non-risk group (n = 1,005,182), non-elderly risk group (n = 308,904) and elderly (n = 422,604), respectively. Among non-elderly risk group conditions, Down syndrome showed the strongest positive association with receiving three doses (adjusted risk ratio [aRR] 1.62, 95% confidence interval [CI] 1.54-1.71), whereas chronic liver disease showed the strongest negative association (aRR 0.90, 95% CI 0.88-0.92). Higher vaccine uptake among the non-elderly risk group was associated with increasing age, being born in Sweden, higher education, higher income and living in a household where other adults had been vaccinated. Similar trends were observed for the first, second, third and fourth doses.\r\n\r\nThese results call for measures to tackle sociodemographic disparities in vaccination programmes during and beyond the COVID-19 pandemic.", "doi": "10.1111/joim.13700", "pmid": "37424218", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Vaccines": null, "Category: Social Science & Humanities": null, "Funder: H2020": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:08:33.778Z", "modified": "2023-10-04T12:38:05.602Z"}, {"entity": "publication", "iuid": "6e47af3193934ba68696ee3e1a095195", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e47af3193934ba68696ee3e1a095195.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e47af3193934ba68696ee3e1a095195"}}, "title": "Diabetes status and other factors as correlates of risk for thrombotic and thromboembolic events during SARS-CoV-2 infection: A nationwide retrospective case-control study using Cerner Real-World Data\u2122.", "authors": [{"family": "Tallon", "given": "Erin M", "initials": "EM", "orcid": "0000-0003-1353-6632", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84a1b4722f504e2f8b66735df7ae7155.json"}}, {"family": "Gallagher", "given": "Mary Pat", "initials": "MP"}, {"family": "Staggs", "given": "Vincent S", "initials": "VS"}, {"family": "Ferro", "given": "Diana", "initials": "D"}, {"family": "Murthy", "given": "Deepa Badrinath", "initials": "DB"}, {"family": "Ebekozien", "given": "Osagie", "initials": "O"}, {"family": "Kosiborod", "given": "Mikhail N", "initials": "MN"}, {"family": "Lind", "given": "Marcus", "initials": "M"}, {"family": "Manrique-Acevedo", "given": "Camila", "initials": "C"}, {"family": "Shyu", "given": "Chi-Ren", "initials": "C"}, {"family": "Clements", "given": "Mark A", "initials": "MA"}], "type": "journal article", "published": "2023-07-09", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "7", "pages": "e071475"}, "abstract": "We sought to examine in individuals with SARS-CoV-2 infection whether risk for thrombotic and thromboembolic events (TTE) is modified by presence of a diabetes diagnosis. Furthermore, we analysed whether differential risk for TTEs exists in type 1 diabetes mellitus (T1DM) versus type 2 diabetes mellitus (T2DM).\r\n\r\nRetrospective case-control study.\r\n\r\nThe December 2020 version of the Cerner Real-World Data COVID-19 database is a deidentified, nationwide database containing electronic medical record (EMR) data from 87 US-based health systems.\r\n\r\nWe analysed EMR data for 322 482 patients >17 years old with suspected or confirmed SARS-CoV-2 infection who received care between December 2019 and mid-September 2020. Of these, 2750 had T1DM; 57 811 had T2DM; and 261 921 did not have diabetes.\r\n\r\nTTE, defined as presence of a diagnosis code for myocardial infarction, thrombotic stroke, pulmonary embolism, deep vein thrombosis or other TTE.\r\n\r\nOdds of TTE were substantially higher in patients with T1DM (adjusted OR (AOR) 2.23 (1.93-2.59)) and T2DM (AOR 1.52 (1.46-1.58)) versus no diabetes. Among patients with diabetes, odds of TTE were lower in T2DM versus T1DM (AOR 0.84 (0.72-0.98)).\r\n\r\nRisk of TTE during COVID-19 illness is substantially higher in patients with diabetes. Further, risk for TTEs is higher in those with T1DM versus T2DM. Confirmation of increased diabetes-associated clotting risk in future studies may warrant incorporation of diabetes status into SARS-CoV-2 infection treatment algorithms.", "doi": "10.1136/bmjopen-2022-071475", "pmid": "37423628", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10335498"}, {"db": "pii", "key": "bmjopen-2022-071475"}], "notes": [], "created": "2023-10-04T12:07:51.817Z", "modified": "2023-10-04T12:27:06.639Z"}, {"entity": "publication", "iuid": "3b0dc67557c1496d8ba7b7707a7eaab4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b0dc67557c1496d8ba7b7707a7eaab4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b0dc67557c1496d8ba7b7707a7eaab4"}}, "title": "Electronic Tongue for Direct Assessment of SARS-CoV-2-Free and Infected Human Saliva-A Feasibility Study.", "authors": [{"family": "Falk", "given": "Magnus", "initials": "M"}, {"family": "Psotta", "given": "Carolin", "initials": "C"}, {"family": "Cirovic", "given": "Stefan", "initials": "S"}, {"family": "Ohlsson", "given": "Lars", "initials": "L"}, {"family": "Shleev", "given": "Sergey", "initials": "S", "orcid": "0000-0001-6421-2158", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de6b1d4bf8f346d4baae7225d7d44876.json"}}], "type": "journal article", "published": "2023-07-07", "journal": {"title": "Biosensors (Basel)", "issn": "2079-6374", "issn-l": null, "volume": "13", "issue": "7", "pages": null}, "abstract": "An electronic tongue is a powerful analytical instrument based on an array of non-selective chemical sensors with a partial specificity for data gathering and advanced pattern recognition methods for data analysis. Connecting electronic tongues with electrochemical techniques for data collection has led to various applications, mostly within sensing for food quality and environmental monitoring, but also in biomedical research for the analyses of different bioanalytes in human physiological fluids. In this paper, an electronic tongue consisting of six electrodes (viz., gold, platinum, palladium, titanium, iridium, and glassy carbon) was designed and tested in authentic (undiluted, unpretreated) human saliva samples from eight volunteers, collected before and during the COVID-19 pandemic. Investigations of 11 samples using differential pulse voltammetry and a principal component analysis allowed us to distinguish between SARS-CoV-2-free and infected authentic human saliva. This work, as a proof-of-principle demonstration, provides a new perspective for the use of electronic tongues in the field of enzyme-free electrochemical biosensing, highlighting their potential for future applications in non-invasive biomedical analyses.", "doi": "10.3390/bios13070717", "pmid": "37504115", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10377364"}, {"db": "pii", "key": "bios13070717"}], "notes": [], "created": "2023-10-04T12:08:28.764Z", "modified": "2023-10-04T12:36:09.449Z"}, {"entity": "publication", "iuid": "f1a822b3d12043ea9b8edf0c56c1d403", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1a822b3d12043ea9b8edf0c56c1d403.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1a822b3d12043ea9b8edf0c56c1d403"}}, "title": "Characterising information loss due to aggregating epidemic model outputs", "authors": [{"family": "Sherratt", "given": "Katharine", "initials": "K", "orcid": "0000-0003-2049-3423", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2318c0e1d33c49bc8315d0b179581b11.json"}}, {"family": "Srivastava", "given": "Ajitesh", "initials": "A"}, {"family": "Ainslie", "given": "Kylie", "initials": "K", "orcid": "0000-0001-5419-7206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d900ed1096f431dbe5a2890503e2ae1.json"}}, {"family": "Singh", "given": "David E", "initials": "DE", "orcid": "0000-0002-8125-0049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f1646cc9a394508ba40e9fe2c2bb75e.json"}}, {"family": "Cublier", "given": "Aymar", "initials": "A"}, {"family": "Marinescu", "given": "Maria Cristina", "initials": "MC", "orcid": "0000-0002-6978-2974", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/afe31d3872854952b2a3f7725a21601b.json"}}, {"family": "Carretero", "given": "Jesus", "initials": "J"}, {"family": "Garcia", "given": "Alberto Cascajo", "initials": "AC", "orcid": "0000-0001-5506-1431", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72d4f2d2fe6c4bf09fd10748c7524706.json"}}, {"family": "Franco", "given": "Nicolas", "initials": "N"}, {"family": "Willem", "given": "Lander", "initials": "L", "orcid": "0000-0002-9210-1196", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/485594f08c334c55bcf8b1159db1befc.json"}}, {"family": "Abrams", "given": "Steven", "initials": "S", "orcid": "0000-0001-7353-9304", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c906aa35960e4612801d310cc7e44780.json"}}, {"family": "Faes", "given": "Christel", "initials": "C", "orcid": "0000-0002-1878-9869", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f126c26524e048eda78269dd8d36f6e9.json"}}, {"family": "Beutels", "given": "Philippe", "initials": "P", "orcid": "0000-0001-5034-3595", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1de885449fe44778dd1839a3737ac97.json"}}, {"family": "Hens", "given": "Niel", "initials": "N", "orcid": "0000-0003-1881-0637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72e67c1e6e6f4d3496183bfcd15c1a18.json"}}, {"family": "M\u00fcller", "given": "Sebastian", "initials": "S"}, {"family": "Charlton", "given": "Billy", "initials": "B", "orcid": "0000-0002-4760-996X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/17046ad3048f43fe9a462a56c9b0ad90.json"}}, {"family": "Ewert", "given": "Ricardo", "initials": "R", "orcid": "0000-0002-6973-3099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a979805944554162b50eb9e860600d56.json"}}, {"family": "Paltra", "given": "Sydney", "initials": "S", "orcid": "0000-0002-4935-8586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/781a2344678d4aed9d4b04b69bec979c.json"}}, {"family": "Rakow", "given": "Christian", "initials": "C", "orcid": "0000-0003-3760-2243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b209fde9192647fe81f8e6a169790bd6.json"}}, {"family": "Rehmann", "given": "Jakob", "initials": "J", "orcid": "0000-0002-1666-6419", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b69a6e1b3534dd3a45d3847e9f1d37b.json"}}, {"family": "Conrad", "given": "Tim", "initials": "T", "orcid": "0000-0002-5590-5726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1512820ad7794988966c276b7270b720.json"}}, {"family": "Sch\u00fctte", "given": "Christof", "initials": "C", "orcid": "0000-0001-5232-2683", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb4b8b18ea234b92b78364166afb1ace.json"}}, {"family": "Nagel", "given": "Kai", "initials": "K", "orcid": "0000-0003-2775-6898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a51017fbe39c432397d0b1dcd9ca69d4.json"}}, {"family": "Grah", "given": "Rok", "initials": "R", "orcid": "0000-0003-2539-3560", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/825d13bbd68a4e3483c5bf5dca6b6233.json"}}, {"family": "Niehus", "given": "Rene", "initials": "R", "orcid": "0000-0002-6751-4124", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92be39b444394d7a82b312737c389cc8.json"}}, {"family": "Prasse", "given": "Bastian", "initials": "B", "orcid": "0000-0002-7935-9109", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/108d55fb4f0b4dbf90a12486fb9fa7bf.json"}}, {"family": "Sandmann", "given": "Frank", "initials": "F", "orcid": "0000-0001-5641-1931", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d25db72e13d48238c49df02d06639b2.json"}}, {"family": "Funk", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-2842-3406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f03dcbc41884648a4eac5892852899a.json"}}], "type": "posted-content", "published": "2023-07-07", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.07.05.23292245", "pmid": null, "labels": {"Type: Preprint": null, "Category: Other": null, "Funder: H2020": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:12:46.584Z", "modified": "2023-10-04T13:35:01.081Z"}, {"entity": "publication", "iuid": "15d790dcf72a433a8f785f425901fed1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15d790dcf72a433a8f785f425901fed1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15d790dcf72a433a8f785f425901fed1"}}, "title": "Characterization of a fieldable process for airborne virus detection", "authors": [{"family": "Du", "given": "Huifeng", "initials": "H", "orcid": "0000-0001-6281-4120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/442acad1a604483aa208a36d5ad7717d.json"}}, {"family": "Bruno", "given": "Simone", "initials": "S", "orcid": "0000-0001-9235-8226", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ab2d583e3cd489888297e07e4d997a0.json"}}, {"family": "Overholt", "given": "Kalon J", "initials": "KJ", "orcid": "0000-0001-9127-9112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7896a963a1da4f259cea799965effb2d.json"}}, {"family": "Palacios", "given": "Sebastian", "initials": "S", "orcid": "0009-0004-5736-147X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b51d649f4924c27b696ae994f76a2ed.json"}}, {"family": "Huang", "given": "Hsin Ho", "initials": "HH"}, {"family": "Barajas", "given": "Carlos", "initials": "C"}, {"family": "Gross", "given": "Ben", "initials": "B"}, {"family": "Lee", "given": "Cindy", "initials": "C"}, {"family": "Evile", "given": "Haley K", "initials": "HK"}, {"family": "de Sousa", "given": "Nuno Rufino", "initials": "NR"}, {"family": "Rothfuchs", "given": "Antonio Gigliotti", "initials": "AG", "orcid": "0000-0001-6001-7240", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00102c49ae2d41828272e850cd551c9f.json"}}, {"family": "Vecchio", "given": "Domitilla Del", "initials": "DD", "orcid": "0000-0001-6472-8576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bad192b794b4e94842be0fbb06788a2.json"}}], "type": "posted-content", "published": "2023-07-06", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.07.03.23292170", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:09:24.813Z", "modified": "2023-10-04T12:52:32.022Z"}, {"entity": "publication", "iuid": "2d28b2c9c308489387829597ab87bf6c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d28b2c9c308489387829597ab87bf6c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d28b2c9c308489387829597ab87bf6c"}}, "title": "Rethinking Immunity: An Ethnography of Risk and Migration in Sweden.", "authors": [{"family": "Mirsalehi", "given": "Talieh", "initials": "T", "orcid": "0000-0003-2864-0280", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d3c5321697fd43039f99d63566bebe47.json"}}], "type": "journal article", "published": "2023-07-04", "journal": {"title": "Med Anthropol", "issn": "1545-5882", "issn-l": null, "volume": "42", "issue": "5", "pages": "493-505"}, "abstract": "I outline the interplay between biological and socio-cultural dimensions of immunity and risk in the context of migration from Afghanistan to Sweden during the COVID-19 pandemic. Documenting my interlocutors' responses to everyday situations, I explore the challenges they face in a new society. Their references to immunity reveal ideas about bodily and biological functions, as well as sociocultural aspects of risk and immunity as fluid concepts. Understanding how different groups manage risk, practice care, and perceive immunity requires attention to the circumstances that surround individual and communal experiences of care practices. I reveal their perceptions, hopes, concerns, and strategies for immunization against the real risks they encounter.", "doi": "10.1080/01459740.2023.2213389", "pmid": "37253110", "labels": {"Category: Social Science & Humanities": null, "Type: Other": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:11:31.458Z", "modified": "2023-10-04T07:14:11.996Z"}, {"entity": "publication", "iuid": "2e07c80ee4504031838349be1d2dd99f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e07c80ee4504031838349be1d2dd99f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e07c80ee4504031838349be1d2dd99f"}}, "title": "Limosilactobacillus reuteri DSM 17938 supplementation and SARS-CoV-2 specific antibody response in healthy adults: a randomized, triple-blinded, placebo-controlled trial.", "authors": [{"family": "Forsg\u00e5rd", "given": "Richard A", "initials": "RA", "orcid": "0000-0002-1905-918X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d1d3d507a034502bec7777d404a9686.json"}}, {"family": "Rode", "given": "Julia", "initials": "J", "orcid": "0000-0001-9402-4756", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77722adb4fff41bebf126c2854614bc8.json"}}, {"family": "Lobenius-Palm\u00e9r", "given": "Karin", "initials": "K", "orcid": "0000-0001-6061-4643", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4cb5a2abe4b5407997d4a2f965091f1b.json"}}, {"family": "Kamm", "given": "Annalena", "initials": "A"}, {"family": "Patil", "given": "Snehal", "initials": "S"}, {"family": "Tacken", "given": "Mirriam G J", "initials": "MGJ"}, {"family": "Lentjes", "given": "Marleen A H", "initials": "MAH", "orcid": "0000-0003-4713-907X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6930e85465646889cd093e3490ed91c.json"}}, {"family": "Axelsson", "given": "Jakob", "initials": "J", "orcid": "0000-0003-4146-8374", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07b58911256b4da4b9fce60d9e364777.json"}}, {"family": "Grompone", "given": "Gianfranco", "initials": "G"}, {"family": "Montgomery", "given": "Scott", "initials": "S"}, {"family": "Brummer", "given": "Robert J", "initials": "RJ", "orcid": "0000-0002-0362-0008", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/320dbc6671aa4870b0e498001e756c01.json"}}], "type": "randomized controlled trial", "published": "2023-07-04", "journal": {"title": "Gut Microbes", "issn": "1949-0984", "issn-l": null, "volume": "15", "issue": "1", "pages": "2229938"}, "abstract": "Studies have shown that probiotics can decrease the symptoms of respiratory tract infections as well as increase antibody responses following certain vaccinations. We examined the effect of probiotic supplementation on anti-SARS-CoV-2 specific antibody responses upon SARS-CoV-2 infection as well as after COVID-19 vaccination. In this randomized, triple-blinded, placebo-controlled intervention study with a parallel design, 159 healthy adults without prior SARS-CoV-2 infection or COVID-19 vaccination and any known risk factors for severe COVID-19 were randomly allocated into two study arms. The active treatment arm consumed a probiotic product containing a minimum of 1 \u00d7 108 colony-forming units of Limosilactobacillus reuteri DSM 17938 + 10 \u03bcg vitamin D3 twice daily for 6 months. The placebo arm consumed identical tablets containing only 10 \u03bcg vitamin D3. Anti-SARS-CoV-2 specific antibodies and virus neutralizing antibody titers were analyzed from blood samples collected at baseline, after 3 months, and after 6 months. Differences in serum antibody titers between the two study arms were tested with independent t-test using log-transformed values. In the intention-to-treat (ITT) analysis, SARS-CoV-2 infected individuals in the active treatment arm (n = 6) tended to have higher serum anti-spike IgG (609 [168-1480] BAU/ml vs 111 [36.1-1210] BAU/ml, p = 0.080) and anti-receptor binding domain (RBD) IgG (928 [212-3449] BAU/ml vs (83.7 [22.8-2094] BAU/ml, p = 0.066) levels than individuals in the placebo arm (n = 6). Considering individuals who were fully vaccinated with mRNA-based COVID-19 vaccines, the active treatment arm (n = 10) exhibited significantly higher serum levels of anti-RBD IgA (135 [32.9-976] BAU/ml vs 61.3 [26.7-97.1] BAU/ml, p = 0.036) than the placebo arm (n = 7) >28 days postvaccination. Supplementation with specific probiotics might improve the long-term efficacy of mRNA-based COVID-19 vaccines via enhanced IgA response.", "doi": "10.1080/19490976.2023.2229938", "pmid": "37401761", "labels": {"Category: Other": null, "Category: Vaccines": null, "Funder: H2020": null}, "xrefs": [{"db": "pmc", "key": "PMC10321188"}], "notes": [], "created": "2023-10-04T12:07:54.497Z", "modified": "2023-10-04T12:28:27.762Z"}, {"entity": "publication", "iuid": "6a8e0b3a19ee4b38b0a41b24e28e3a03", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a8e0b3a19ee4b38b0a41b24e28e3a03.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a8e0b3a19ee4b38b0a41b24e28e3a03"}}, "title": "Policies and resources for strengthening of emergency and critical care services in the context of the global COVID-19 pandemic in Kenya.", "authors": [{"family": "Oliwa", "given": "Jacquie Narotso", "initials": "JN", "orcid": "0000-0002-4575-2447", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9eae04e0d0fe47fc9263e1014a63a88d.json"}}, {"family": "Mazhar", "given": "Rosanna Jeffries", "initials": "RJ", "orcid": "0000-0003-2367-2072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/acca58542d9a49088ecbddbf9e0c4c99.json"}}, {"family": "Serem", "given": "George", "initials": "G"}, {"family": "Khalid", "given": "Karima", "initials": "K"}, {"family": "Amoth", "given": "Patrick", "initials": "P"}, {"family": "Kiarie", "given": "Helen", "initials": "H", "orcid": "0000-0003-2048-8173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b6b816132dba47889ba7e551e83d4fcf.json"}}, {"family": "Warfa", "given": "Osman", "initials": "O"}, {"family": "Schell", "given": "Carl Otto", "initials": "CO", "orcid": "0000-0002-7904-1336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a40b337b45b471d97a102c355c9d874.json"}}, {"family": "Baker", "given": "Tim", "initials": "T", "orcid": "0000-0001-8727-7018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1454fc20049b4d47865268adf16d104a.json"}}, {"family": "English", "given": "Mike", "initials": "M", "orcid": "0000-0002-7427-0826", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d680cdafc8854a619f1919652dd16aed.json"}}, {"family": "Mcknight", "given": "Jacob", "initials": "J"}], "type": "journal article", "published": "2023-07-03", "journal": {"title": "PLOS Glob Public Health", "issn": "2767-3375", "issn-l": null, "volume": "3", "issue": "7", "pages": "e0000483"}, "abstract": "Critical illnesses cause several million deaths annually, with many of these occurring in low-resource settings like Kenya. Great efforts have been made worldwide to scale up critical care to reduce deaths from COVID-19. Lower income countries with fragile health systems may not have had sufficient resources to upscale their critical care. We aimed to review how efforts to strengthen emergency and critical care were operationalised during the pandemic in Kenya to point towards how future emergencies should be approached. This was an exploratory study that involved document reviews, and discussions with key stakeholders (donors, international agencies, professional associations, government actors), during the first year of the pandemic in Kenya. Our findings suggest that pre-pandemic health services for the critically ill in Kenya were sparse and unable to meet rising demand, with major limitations noted in human resources and infrastructure. The pandemic response saw galvanised action by the Government of Kenya and other agencies to mobilise resources (approximately USD 218 million). Earlier efforts were largely directed towards advanced critical care but since the human resource gap could not be reduced immediately, a lot of equipment remained unused. We also note that despite strong policies on what resources should be available, the reality on the ground was that there were often critical shortages. While emergency response mechanisms are not conducive to addressing long-term health system issues, the pandemic increased global recognition of the need to fund care for the critically ill. Limited resources may be best prioritised towards a public health approach with focus on provision of relatively basic, lower cost essential emergency and critical care (EECC) that can potentially save the most lives amongst critically ill patients.", "doi": "10.1371/journal.pgph.0000483", "pmid": "37399177", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10317215"}, {"db": "pii", "key": "PGPH-D-22-00633"}], "notes": [], "created": "2023-10-04T12:10:47.776Z", "modified": "2023-10-04T13:31:35.356Z"}, {"entity": "publication", "iuid": "ad853f575d43489183421c0102c22497", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ad853f575d43489183421c0102c22497.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ad853f575d43489183421c0102c22497"}}, "title": "Relationship between People's Interest in Medication Adherence, Health Literacy, and Self-Care: An Infodemiological Analysis in the Pre- and Post-COVID-19 Era.", "authors": [{"family": "Grandieri", "given": "Andrea", "initials": "A", "orcid": "0000-0003-0553-5971", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e8a8fbb98fa4b2fbbb37e729c9276aa.json"}}, {"family": "Trevisan", "given": "Caterina", "initials": "C"}, {"family": "Gentili", "given": "Susanna", "initials": "S"}, {"family": "Vetrano", "given": "Davide Liborio", "initials": "DL", "orcid": "0000-0002-3099-4830", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0124721bb214413a34c965b6accc64b.json"}}, {"family": "Liotta", "given": "Giuseppe", "initials": "G"}, {"family": "Volpato", "given": "Stefano", "initials": "S"}], "type": "journal article", "published": "2023-07-01", "journal": {"title": "J Pers Med", "issn": "2075-4426", "issn-l": null, "volume": "13", "issue": "7", "pages": null}, "abstract": "The prevalence of non-communicable diseases has risen sharply in recent years, particularly among older individuals who require complex drug regimens. Patients are increasingly required to manage their health through medication adherence and self-care, but about 50% of patients struggle to adhere to prescribed treatments. This study explored the relationship between interest in medication adherence, health literacy, and self-care and how it changed during the COVID-19 pandemic. We used Google Trends to measure relative search volumes (RSVs) for these three topics from 2012 to 2022. We found that interest in self-care increased the most over time, followed by health literacy and medication adherence. Direct correlations emerged between RSVs for medication adherence and health literacy (r = 0.674, p < 0.0001), medication adherence and self-care (r = 0.466, p < 0.0001), and health literacy and self-care (r = 0.545, p < 0.0001). After the COVID-19 pandemic outbreak, interest in self-care significantly increased, and Latin countries showed a greater interest in self-care than other geographical areas. This study suggests that people are increasingly interested in managing their health, especially in the context of the recent pandemic, and that infodemiology may provide interesting information about the attitudes of the population toward chronic disease management.", "doi": "10.3390/jpm13071090", "pmid": "37511703", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10381156"}, {"db": "pii", "key": "jpm13071090"}], "notes": [], "created": "2023-10-04T12:09:58.719Z", "modified": "2023-10-04T13:06:56.219Z"}, {"entity": "publication", "iuid": "f8e34c2bbc934c90b3e24f59dbffe111", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f8e34c2bbc934c90b3e24f59dbffe111.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f8e34c2bbc934c90b3e24f59dbffe111"}}, "title": "Preclinical and Human Phase 1 Studies of Aerosolized Hydroxychloroquine: Implications for Antiviral COVID-19 Therapy", "authors": [{"family": "Bentur", "given": "Ohad S", "initials": "OS", "orcid": "0000-0002-5976-7121", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30bdc9224fad462196908646f277a76f.json"}}, {"family": "Hutt", "given": "Richard", "initials": "R"}, {"family": "Brassil", "given": "Donna", "initials": "D"}, {"family": "Kriegegr", "given": "Ana C", "initials": "AC"}, {"family": "B\u00e4ckman", "given": "Per", "initials": "P"}, {"family": "Charous", "given": "B Lauren", "initials": "BL"}, {"family": "Boushey", "given": "Homer", "initials": "H", "orcid": "0000-0002-4373-9265", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e67d654785c2406fb0ce1ba5f3d384a3.json"}}, {"family": "Gonda", "given": "Igor", "initials": "I"}, {"family": "Coller", "given": "Barry S", "initials": "BS", "orcid": "0000-0002-9078-7155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/648db6fb396f49938d98dcdc82b63658.json"}}, {"family": "MacArthur", "given": "Robert B", "initials": "RB", "orcid": "0000-0002-3264-4666", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a38b7120c21a4985be747fc84e7d9bd0.json"}}], "type": "posted-content", "published": "2023-07-01", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.06.22.23291702", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:07:45.920Z", "modified": "2023-10-04T12:24:46.443Z"}, {"entity": "publication", "iuid": "2090449e3a554ddc86000f62047f458c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2090449e3a554ddc86000f62047f458c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2090449e3a554ddc86000f62047f458c"}}, "title": "Use of the neutrophil-to-lymphocyte ratio and an oxygen requirement to predict disease severity in patients with COVID-19.", "authors": [{"family": "Ozawa", "given": "Takuya", "initials": "T"}, {"family": "Asakura", "given": "Takanori", "initials": "T"}, {"family": "Chubachi", "given": "Shotaro", "initials": "S"}, {"family": "Namkoong", "given": "Ho", "initials": "H"}, {"family": "Tanaka", "given": "Hiromu", "initials": "H"}, {"family": "Lee", "given": "Ko", "initials": "K"}, {"family": "Fukushima", "given": "Takahiro", "initials": "T"}, {"family": "Otake", "given": "Shiro", "initials": "S"}, {"family": "Nakagawara", "given": "Kensuke", "initials": "K"}, {"family": "Watase", "given": "Mayuko", "initials": "M"}, {"family": "Masaki", "given": "Katsunori", "initials": "K"}, {"family": "Kamata", "given": "Hirofumi", "initials": "H"}, {"family": "Ishii", "given": "Makoto", "initials": "M"}, {"family": "Hasegawa", "given": "Naoki", "initials": "N"}, {"family": "Harada", "given": "Norihiro", "initials": "N"}, {"family": "Ueda", "given": "Tetsuya", "initials": "T"}, {"family": "Ueda", "given": "Soichiro", "initials": "S"}, {"family": "Ishiguro", "given": "Takashi", "initials": "T"}, {"family": "Arimura", "given": "Ken", "initials": "K"}, {"family": "Saito", "given": "Fukuki", "initials": "F"}, {"family": "Yoshiyama", "given": "Takashi", "initials": "T"}, {"family": "Nakano", "given": "Yasushi", "initials": "Y"}, {"family": "Mutoh", "given": "Yoshikazu", "initials": "Y"}, {"family": "Suzuki", "given": "Yusuke", "initials": "Y"}, {"family": "Edahiro", "given": "Ryuya", "initials": "R"}, {"family": "Murakami", "given": "Koji", "initials": "K"}, {"family": "Okada", "given": "Yukinori", "initials": "Y"}, {"family": "Koike", "given": "Ryuji", "initials": "R"}, {"family": "Kitagawa", "given": "Yuko", "initials": "Y"}, {"family": "Tokunaga", "given": "Katsushi", "initials": "K"}, {"family": "Kimura", "given": "Akinori", "initials": "A"}, {"family": "Imoto", "given": "Seiya", "initials": "S"}, {"family": "Miyano", "given": "Satoru", "initials": "S"}, {"family": "Ogawa", "given": "Seishi", "initials": "S"}, {"family": "Kanai", "given": "Takanori", "initials": "T"}, {"family": "Fukunaga", "given": "Koichi", "initials": "K"}, {"family": "Japan COVID-19 Task Force", "given": "", "initials": ""}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Respir Investig", "issn": "2212-5353", "issn-l": null, "volume": "61", "issue": "4", "pages": "454-459"}, "abstract": "We investigated the association between complete blood count, including neutrophil-to-lymphocyte ratio (NLR) in combination with patient characteristics, and coronavirus disease (COVID-19) outcomes to identify the best prognostic indicator. We analyzed data of patients with confirmed COVID-19 from the nationwide database of the Japan COVID-19 Task Force between February 2020 and November 2021. A composite outcome was defined as the most severe condition, including noninvasive positive-pressure ventilation, high-flow nasal cannula, invasive mechanical ventilation, extracorporeal membrane oxygenation, or death. Of 2425 patients in the analysis, 472 (19.5%) experienced a composite outcome. NLR was the best predictor of composite outcomes, with an area under the curve (AUC) of 0.81, and a sensitivity and specificity of 72.3% and 75.7%, respectively, using a cut-off value of 5.04. The combination of NLR and an oxygen requirement on admission had the highest AUC (0.88). This simple combination may help identify patients at risk of progression to severe disease.", "doi": "10.1016/j.resinv.2023.03.007", "pmid": "37121116", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Category: Serology": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10113601"}, {"db": "pii", "key": "S2212-5345(23)00037-0"}], "notes": [], "created": "2023-10-04T05:11:33.967Z", "modified": "2023-10-04T07:15:20.168Z"}, {"entity": "publication", "iuid": "bede0574495043b5a03b3f9b2178cfea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bede0574495043b5a03b3f9b2178cfea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bede0574495043b5a03b3f9b2178cfea"}}, "title": "The association between leisure engagement and loneliness before and during the COVID-19 pandemic: A Nordic population-based study.", "authors": [{"family": "Nyqvist", "given": "Fredrica", "initials": "F", "orcid": "0000-0001-6554-8040", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc9027ea4dc241a18acd24a108cf33ce.json"}}, {"family": "Nilsson", "given": "Ingeborg", "initials": "I"}, {"family": "N\u00e4sman", "given": "Marina", "initials": "M"}, {"family": "Olofsson", "given": "Birgitta", "initials": "B"}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": "51", "issue": "5", "pages": "744-753"}, "abstract": "The main aim of this study was to examine leisure engagement and loneliness among older adults before and during the COVID-19 pandemic by analysing population-based data from western Finland and northern Sweden.\r\n\r\nThe data originated from the Gerontological Regional Database (GERDA) postal questionnaire study conducted in 2016 (n=7996) and 2021 (n=8148) among older adults aged 65, 70, 75, 80 and 85 years. Associations between loneliness and leisure engagement were analysed using logistic regression.\r\n\r\nIn total, 10% and 9% of the older adults reported loneliness in 2016 and 2021, respectively. The results showed that a lack of engagement in socialising and pleasure was independently associated with loneliness in both study years, while a lack of engagement in cultural activities was associated with loneliness in 2016 only. In 2021, the likelihood of experiencing loneliness was higher in the Finnish region than in the Swedish region. In addition, those reporting a decrease in hobby and socialising leisure activities due to the COVID-19 pandemic were more likely to report loneliness.\r\n\r\nMost leisure activities decreased during the pandemic, suggesting an increase in social isolation. However, this did not reflect an increase in loneliness in the studied regions. The evidence suggests that leisure engagement, especially socialising activities, continued to be important for well-being among older adults during the pandemic. Further, loneliness was affected by contextual factors as well as individual-level characteristics. Thus, according to the measures reported here, the pandemic seemed to have a slightly weakened well-being impact in Finland.", "doi": "10.1177/14034948231171964", "pmid": "37165572", "labels": {"Category: Social Science & Humanities": null, "Funder: VR": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10183342"}], "notes": [], "created": "2023-10-04T05:11:21.823Z", "modified": "2023-10-04T07:10:17.734Z"}, {"entity": "publication", "iuid": "770c1621ca0a42a8a46ddebe70cb92e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/770c1621ca0a42a8a46ddebe70cb92e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/770c1621ca0a42a8a46ddebe70cb92e1"}}, "title": "Taking Risks to Protect Others-Pediatric Vaccination and Moral Responsibility.", "authors": [{"family": "Nihl\u00e9n Fahlquist", "given": "Jessica", "initials": "J", "orcid": "0000-0001-9683-7005", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/927d3a3a934a45dca7f88072507aa153.json"}}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Public Health Ethics", "issn": "1754-9973", "issn-l": null, "volume": "16", "issue": "2", "pages": "127-138"}, "abstract": "The COVID-19 pandemic during 2020-2022 raised ethical questions concerning the balance between individual autonomy and the protection of the population, vulnerable individuals and the healthcare system. Pediatric COVID-19 vaccination differs from, for example, measles vaccination in that children were not as severely affected. The main question concerning pediatric vaccination has been whether the autonomy of parents outweighs the protection of the population. When children are seen as mature enough to be granted autonomy, questions arise about whether they have the right to decline vaccination and who should make the decision when parents disagree with each other and/or the child. In this paper, I argue that children should be encouraged to not only take responsibility for themselves, but for others. The discussion of pediatric vaccination in cases where this kind of risk-benefit ratio exists extends beyond the 2020-2022 pandemic. The pandemic entailed a question that is crucial for the future of public health as a global problem, that is, to what extent children should be seen as responsible decision-makers who are capable of contributing to its management and potential solution. I conclude that society should encourage children to cultivate such responsibility, conceived as a virtue, in the context of public health.", "doi": "10.1093/phe/phad005", "pmid": "37547911", "labels": {"Category: Public Health": null, "Type: Other": null, "Category: Vaccines": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10401494"}, {"db": "pii", "key": "phad005"}], "notes": [], "created": "2023-10-05T08:26:21.511Z", "modified": "2023-10-06T04:56:09.662Z"}, {"entity": "publication", "iuid": "07fa0b12e97341debcc3e6aab2a33c15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07fa0b12e97341debcc3e6aab2a33c15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07fa0b12e97341debcc3e6aab2a33c15"}}, "title": "Prognostic potential of creatinine and Cystatin C in COVID-19 - a retrospective cohort study from Karolinska University Hospital.", "authors": [{"family": "Sj\u00f6str\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Markgren", "given": "Per Olof", "initials": "PO"}, {"family": "Hansson", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Scand J Clin Lab Invest", "issn": "1502-7686", "issn-l": null, "volume": "83", "issue": "4", "pages": "251-257"}, "abstract": "Acute kidney injury (AKI) is common in COVID-19 and is diagnosed using relative serum creatinine increase. Estimated GFR (eGFR) is a more accurate measure of glomerular filtration due to compensation for age and sex. Serum Cystatin-C, less affected by non-renal factors than creatinine, may further improve renal function estimation and add prognostic information. Our aim is to investigate the importance of a calculated eGFR in relation to creatinine as well as the value of Cystatin-C in patients with severe COVID-19. This study is a retrospective cohort study investigating levels and trends of routine laboratory parameters combined with clinical data from 286 consecutive patients with severe COVID-19 from Karolinska University Hospital. AKI developed in 38% of the patients and 15% were treated with hemodialysis. Mortality in the AKI group was 42% compared to 5% in the non-AKI group. At admission, eGFR, but not creatinine, was significantly associated with AKI development, need of intubation and mortality. Moreover, discrepant results between eGFR creatinine (eGFRCR) and eGFR Cystatin-C (eGFRCYS) was common in the ICU patients compared to non-ICU patients and related to outcome. In addition, we found that daily median Cystatin-C levels during the hospital stay were correlated to neutrophil count. eGFRCR was found to be an overall better prognostic marker than creatinine regarding AKI development and prognosis in severe COVID-19. Fulfillment of Shrunken pore syndrome criteria indicated a higher mortality risk. Cystatin-C may be related to neutrophil count, which could be a clue to the discrepant eGFR results.", "doi": "10.1080/00365513.2023.2210291", "pmid": "37167478", "labels": {"Category: Proteins": null, "Category: Serology": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:10:12.197Z", "modified": "2023-10-04T06:28:40.854Z"}, {"entity": "publication", "iuid": "6acd649d6131409fba5f319ad7ac1f48", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6acd649d6131409fba5f319ad7ac1f48.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6acd649d6131409fba5f319ad7ac1f48"}}, "title": "Prognostic performance of blood neurofilament light chain protein in hospitalized COVID-19 patients without major central nervous system manifestations: an individual participant data meta-analysis.", "authors": [{"family": "Abdelhak", "given": "Ahmed", "initials": "A", "orcid": "0000-0001-9731-4169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2c3007e2b3e4af0855c4f64b89a1f69.json"}}, {"family": "Barba", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-4237-6850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0cec76ce00c94352aac33ccbf3a5028d.json"}}, {"family": "Romoli", "given": "Michele", "initials": "M", "orcid": "0000-0001-8009-8543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/954e16c7c9934d23b7b8a489adccf2d4.json"}}, {"family": "Benkert", "given": "Pascal", "initials": "P", "orcid": "0000-0001-6525-8174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a8e93f751ae40cbadbd19d8840639fe.json"}}, {"family": "Conversi", "given": "Francesco", "initials": "F"}, {"family": "D'Anna", "given": "Lucio", "initials": "L", "orcid": "0000-0002-6794-3850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1601767932dc4a4d9a8d0b5113763600.json"}}, {"family": "Masvekar", "given": "Ruturaj R", "initials": "RR", "orcid": "0000-0002-4570-4533", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25270f2a54cf416b9dde587dab0ade04.json"}}, {"family": "Bielekova", "given": "Bibiana", "initials": "B", "orcid": "0000-0002-0959-9430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b2a7812ae084c4b8b8f69168032e0b1.json"}}, {"family": "Prudencio", "given": "Mercedes", "initials": "M", "orcid": "0000-0002-4894-4858", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6206178f7b0448ffb963acacf6e37023.json"}}, {"family": "Petrucelli", "given": "Leonard", "initials": "L", "orcid": "0000-0003-2959-129X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46d6fe83e1494ae6be0214bd3b41e4ef.json"}}, {"family": "Meschia", "given": "James F", "initials": "JF", "orcid": "0000-0002-4475-8142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/590bd75802c640a0949896e6aa8befc8.json"}}, {"family": "Erben", "given": "Young", "initials": "Y", "orcid": "0000-0002-1571-6955", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b026b60bc68648579b7e0370ff00c0fe.json"}}, {"family": "Furlan", "given": "Roberto", "initials": "R", "orcid": "0000-0001-7376-9425", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/940db6ecfcbd4383a1369393fa8e206e.json"}}, {"family": "De Lorenzo", "given": "Rebecca", "initials": "R", "orcid": "0000-0002-1281-7996", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1eddd82f29f64c889211037bb64cf707.json"}}, {"family": "Mandelli", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-6494-7776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4d010bf83e14566bceae44bcd63d36c.json"}}, {"family": "Sutter", "given": "Raoul", "initials": "R", "orcid": "0000-0002-6575-356X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0a395e40bd6464084ec2cddd90f2295.json"}}, {"family": "Hert", "given": "Lisa", "initials": "L"}, {"family": "Epple", "given": "Varenka", "initials": "V", "orcid": "0000-0002-8736-0070", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7773c7cf8f4541019af057e2bbbdeefa.json"}}, {"family": "Marastoni", "given": "Damiano", "initials": "D", "orcid": "0000-0003-0358-9431", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af2ff46eb01a473aa077029d582903b2.json"}}, {"family": "Sellner", "given": "Johann", "initials": "J", "orcid": "0000-0001-8749-5533", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/38b82ef4d31a4939be4e1024faa664bb.json"}}, {"family": "Steinacker", "given": "Petra", "initials": "P"}, {"family": "Aamodt", "given": "Anne Hege", "initials": "AH", "orcid": "0000-0002-2824-2760", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b21211bae394fef867be93f162d8ef8.json"}}, {"family": "Heggelund", "given": "Lars", "initials": "L", "orcid": "0000-0002-1669-1032", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9befa124c647487d803e8dba68495821.json"}}, {"family": "Dyrhol-Riise", "given": "Anne Margarita", "initials": "AM", "orcid": "0000-0003-4009-4032", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/051b91855a064394a525b898992aa834.json"}}, {"family": "Virhammar", "given": "Johan", "initials": "J", "orcid": "0000-0001-9901-2949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9db4ac69a3e8495ea8e71ae60042fa5c.json"}}, {"family": "F\u00e4llmar", "given": "David", "initials": "D", "orcid": "0000-0001-5615-2036", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08e1206ab94a43788a7fc641ee13407c.json"}}, {"family": "Rostami", "given": "Elham", "initials": "E", "orcid": "0000-0003-1218-6247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c95efe7a4cc4fcfa73fac8b49641ca1.json"}}, {"family": "Kumlien", "given": "Eva", "initials": "E", "orcid": "0000-0002-1952-8791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de1d39588b21438fabae7d27acf4b237.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/351fab09f6e24b9f9e6695da83947cb6.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e314740b02c344d2b336a9410e28041e.json"}}, {"family": "Tumani", "given": "Hayrettin", "initials": "H", "orcid": "0000-0002-1647-6201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c76797ddf9d4909a1c5f2140ec3531e.json"}}, {"family": "Sacco", "given": "Simona", "initials": "S", "orcid": "0000-0003-0651-1939", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0447acf2277a43049232a0ad7614d310.json"}}, {"family": "Green", "given": "Ari J", "initials": "AJ", "orcid": "0000-0001-9275-3066", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/829f4905eef64f6b980141ae7b2e6f9b.json"}}, {"family": "Otto", "given": "Markus", "initials": "M", "orcid": "0000-0003-4273-4267", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e472a52c9d04a9fa4161d80fa0c6bdb.json"}}, {"family": "Kuhle", "given": "Jens", "initials": "J", "orcid": "0000-0002-6963-8892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/187936aaf8c342e58dec7adc5b23ad91.json"}}, {"family": "Ornello", "given": "Raffaele", "initials": "R", "orcid": "0000-0001-9501-4031", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/133160eee8a942dd9f7d6cad321520c6.json"}}, {"family": "Foschi", "given": "Matteo", "initials": "M", "orcid": "0000-0002-0321-7155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc49b113289e4deabff8a47fdf0bea6d.json"}}, {"family": "Abu-Rumeileh", "given": "Samir", "initials": "S", "orcid": "0000-0003-0631-8506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8531166b14e04d998571b80fb0e761ff.json"}}], "type": "meta-analysis", "published": "2023-07-00", "journal": {"title": "J Neurol", "issn": "1432-1459", "issn-l": null, "volume": "270", "issue": "7", "pages": "3315-3328"}, "abstract": "To investigate the prognostic value of blood neurofilament light chain protein (NfL) levels in the acute phase of coronavirus disease 2019 (COVID-19).\r\n\r\nWe conducted an individual participant data (IPD) meta-analysis after screening on MEDLINE and Scopus to May 23rd 2022. We included studies with hospitalized adult COVID-19 patients without major COVID-19-associated central nervous system (CNS) manifestations and with a measurement of blood NfL in the acute phase as well as data regarding at least one clinical outcome including intensive care unit (ICU) admission, need of mechanical ventilation (MV) and death. We derived the age-adjusted measures NfL Z scores and conducted mixed-effects modelling to test associations between NfL Z scores and other variables, encompassing clinical outcomes. Summary receiver operating characteristic curves (SROCs) were used to calculate the area under the curve (AUC) for blood NfL.\r\n\r\nWe identified 382 records, of which 7 studies were included with a total of 669 hospitalized COVID-19 cases (mean age 66.2 \u00b1 15.0 years, 68.1% males). Median NfL Z score at admission was elevated compared to the age-corrected reference population (2.37, IQR: 1.13-3.06, referring to 99th percentile in healthy controls). NfL Z scores were significantly associated with disease duration and severity. Higher NfL Z scores were associated with a higher likelihood of ICU admission, need of MV, and death. SROCs revealed AUCs of 0.74, 0.80 and 0.71 for mortality, need of MV and ICU admission, respectively.\r\n\r\nBlood NfL levels were elevated in the acute phase of COVID-19 patients without major CNS manifestations and associated with clinical severity and poor outcome. The marker might ameliorate the performance of prognostic multivariable algorithms in COVID-19.", "doi": "10.1007/s00415-023-11768-1", "pmid": "37184659", "labels": {"Category: Health": null, "Category: Proteins": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10183689"}, {"db": "pii", "key": "10.1007/s00415-023-11768-1"}], "notes": [], "created": "2023-10-04T05:10:19.728Z", "modified": "2023-10-04T06:35:13.442Z"}, {"entity": "publication", "iuid": "25d376987001470aa29efeaa325aa75e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/25d376987001470aa29efeaa325aa75e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/25d376987001470aa29efeaa325aa75e"}}, "title": "New evidence of gender inequality during COVID-19 outbreak in the Middle East and North Africa.", "authors": [{"family": "Abdel-Rahman", "given": "Suzan", "initials": "S"}, {"family": "Awwad", "given": "Fuad A", "initials": "FA"}, {"family": "Qasim", "given": "Muhammad", "initials": "M"}, {"family": "Abonazel", "given": "Mohamed R", "initials": "MR"}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "issn-l": null, "volume": "9", "issue": "7", "pages": "e17705"}, "abstract": "The COVID-19 pandemic has significantly altered employment and income distribution, impacting women and men differently. This study investigates the negative effects of COVID-19 on the labour market, focusing on the gender gap in five countries in the Middle East and North Africa (MENA) region. The study indicates whether women are more susceptible to losing their jobs, either temporarily or permanently, switching their primary occupation, and experiencing decreased working hours and income compared to men during the COVID-19 outbreak. The study utilizes a multivariate Probit model to estimate the relationship between gender and adverse labour outcomes controlling for correlations among outcomes. Data are obtained from the Combined COVID-19 MENA Monitor Household Survey, covering Egypt, Tunisia, Morocco, Jordan, and Sudan. The findings of this study offer empirical evidence of the gender gap in labour market outcomes during the pandemic. Women are more likely than men to experience negative work outcomes, such as permanent job loss and change in their main job. The increased childcare and housework responsibilities have significantly impacted women's labour market outcomes during the pandemic. However, the availability of telework has reduced the likelihood of job loss among women. The study's results contribute to a better understanding of the impact of COVID-19 on gender inequality in understudied MENA countries. Mitigation policies should focus on supporting vulnerable women who have experienced disproportionate negative effects of COVID-19.", "doi": "10.1016/j.heliyon.2023.e17705", "pmid": "37456038", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10338972"}, {"db": "pii", "key": "S2405-8440(23)04913-7"}], "notes": [], "created": "2023-10-04T12:09:05.868Z", "modified": "2023-10-04T12:49:06.026Z"}, {"entity": "publication", "iuid": "c2ca3f8574624b31bb877b6129945208", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2ca3f8574624b31bb877b6129945208.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2ca3f8574624b31bb877b6129945208"}}, "title": "Mucosal immune responses following a fourth SARS-CoV-2 vaccine dose.", "authors": [{"family": "Bladh", "given": "Oscar", "initials": "O"}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Norin", "given": "Nina Greilert", "initials": "NG"}, {"family": "Aguilera", "given": "Katherina", "initials": "K"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "letter", "published": "2023-07-00", "journal": {"title": "The Lancet Microbe", "issn": "2666-5247", "volume": "4", "issue": "7", "pages": "e488", "issn-l": "2666-5247"}, "abstract": null, "doi": "10.1016/S2666-5247(23)00102-7", "pmid": "37086736", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pmc", "key": "PMC10115585"}, {"db": "pii", "key": "S2666-5247(23)00102-7"}], "notes": [], "created": "2023-07-13T11:38:02.948Z", "modified": "2023-07-13T11:38:42.510Z"}, {"entity": "publication", "iuid": "c1ef68d3ddce4d4ea525ceeccd27a474", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1ef68d3ddce4d4ea525ceeccd27a474.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1ef68d3ddce4d4ea525ceeccd27a474"}}, "title": "Impact of the COVID-19 pandemic on Swedish adults aged 77 years and older: Age differences in lifestyle changes.", "authors": [{"family": "Augustsson", "given": "Erika", "initials": "E", "orcid": "0000-0001-9958-4090", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0cd1d8d125cc426e9c0d9c587fbc9513.json"}}, {"family": "Von Saenger", "given": "Isabelle", "initials": "I"}, {"family": "Agahi", "given": "Neda", "initials": "N"}, {"family": "K\u00e5reholt", "given": "Ingemar", "initials": "I"}, {"family": "Ericsson", "given": "Malin", "initials": "M"}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": "51", "issue": "5", "pages": "764-768"}, "abstract": "This study aimed to describe the impact of the COVID-19 pandemic on lifestyle and social activities among older adults in Sweden, with a special focus on differences between the 'younger old' (aged 77-84) and 'older old' (aged 85-109).\r\n\r\nThis study is based on a nationally representative sample of older adults (aged \u2a7e77 years) in Sweden (SWEOLD). Data were collected between May 2021 and April 2022, when many recommendations were removed but the virus was still classified as a public health disease. We studied occurrences and differences between the two age groups in several lifestyle factors and social activities.\r\n\r\nThe younger old displayed larger changes in lifestyles because of the pandemic than the older old. Most changes were found in social interactions with family.\r\n\r\nOur results highlight the large heterogeneity within the Swedish population aged \u2a7e77 years, and that the younger old experienced a bigger lifestyle change than the older old. Previous activity levels might be important to consider in order to understand how regulations may affect the older population. Finally, our findings indicate large age differences in Internet use, which require attention to prevent digital exclusion of an already vulnerable group.", "doi": "10.1177/14034948231172249", "pmid": "37151122", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10170261"}], "notes": [], "created": "2023-10-04T05:12:01.762Z", "modified": "2023-10-04T07:26:10.285Z"}, {"entity": "publication", "iuid": "41d8faa1aee942a1b8f3986561852142", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41d8faa1aee942a1b8f3986561852142.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41d8faa1aee942a1b8f3986561852142"}}, "title": "ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies.", "authors": [{"family": "Grasselli", "given": "Giacomo", "initials": "G", "orcid": "0000-0002-1735-1400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a68eafa11dae413bb14842cfb8647144.json"}}, {"family": "Calfee", "given": "Carolyn S", "initials": "CS"}, {"family": "Camporota", "given": "Luigi", "initials": "L"}, {"family": "Poole", "given": "Daniele", "initials": "D"}, {"family": "Amato", "given": "Marcelo B P", "initials": "MBP"}, {"family": "Antonelli", "given": "Massimo", "initials": "M"}, {"family": "Arabi", "given": "Yaseen M", "initials": "YM"}, {"family": "Baroncelli", "given": "Francesca", "initials": "F"}, {"family": "Beitler", "given": "Jeremy R", "initials": "JR"}, {"family": "Bellani", "given": "Giacomo", "initials": "G"}, {"family": "Bellingan", "given": "Geoff", "initials": "G"}, {"family": "Blackwood", "given": "Bronagh", "initials": "B"}, {"family": "Bos", "given": "Lieuwe D J", "initials": "LDJ"}, {"family": "Brochard", "given": "Laurent", "initials": "L"}, {"family": "Brodie", "given": "Daniel", "initials": "D"}, {"family": "Burns", "given": "Karen E A", "initials": "KEA"}, {"family": "Combes", "given": "Alain", "initials": "A"}, {"family": "D'Arrigo", "given": "Sonia", "initials": "S"}, {"family": "De Backer", "given": "Daniel", "initials": "D"}, {"family": "Demoule", "given": "Alexandre", "initials": "A"}, {"family": "Einav", "given": "Sharon", "initials": "S"}, {"family": "Fan", "given": "Eddy", "initials": "E"}, {"family": "Ferguson", "given": "Niall D", "initials": "ND"}, {"family": "Frat", "given": "Jean-Pierre", "initials": "J"}, {"family": "Gattinoni", "given": "Luciano", "initials": "L"}, {"family": "Gu\u00e9rin", "given": "Claude", "initials": "C"}, {"family": "Herridge", "given": "Margaret S", "initials": "MS"}, {"family": "Hodgson", "given": "Carol", "initials": "C"}, {"family": "Hough", "given": "Catherine L", "initials": "CL"}, {"family": "Jaber", "given": "Samir", "initials": "S"}, {"family": "Juffermans", "given": "Nicole P", "initials": "NP"}, {"family": "Karagiannidis", "given": "Christian", "initials": "C"}, {"family": "Kesecioglu", "given": "Jozef", "initials": "J"}, {"family": "Kwizera", "given": "Arthur", "initials": "A"}, {"family": "Laffey", "given": "John G", "initials": "JG"}, {"family": "Mancebo", "given": "Jordi", "initials": "J"}, {"family": "Matthay", "given": "Michael A", "initials": "MA"}, {"family": "McAuley", "given": "Daniel F", "initials": "DF"}, {"family": "Mercat", "given": "Alain", "initials": "A"}, {"family": "Meyer", "given": "Nuala J", "initials": "NJ"}, {"family": "Moss", "given": "Marc", "initials": "M"}, {"family": "Munshi", "given": "Laveena", "initials": "L"}, {"family": "Myatra", "given": "Sheila N", "initials": "SN"}, {"family": "Ng Gong", "given": "Michelle", "initials": "M"}, {"family": "Papazian", "given": "Laurent", "initials": "L"}, {"family": "Patel", "given": "Bhakti K", "initials": "BK"}, {"family": "Pellegrini", "given": "Mariangela", "initials": "M"}, {"family": "Perner", "given": "Anders", "initials": "A"}, {"family": "Pesenti", "given": "Antonio", "initials": "A"}, {"family": "Piquilloud", "given": "Lise", "initials": "L"}, {"family": "Qiu", "given": "Haibo", "initials": "H"}, {"family": "Ranieri", "given": "Marco V", "initials": "MV"}, {"family": "Riviello", "given": "Elisabeth", "initials": "E"}, {"family": "Slutsky", "given": "Arthur S", "initials": "AS"}, {"family": "Stapleton", "given": "Renee D", "initials": "RD"}, {"family": "Summers", "given": "Charlotte", "initials": "C"}, {"family": "Thompson", "given": "Taylor B", "initials": "TB"}, {"family": "Valente Barbas", "given": "Carmen S", "initials": "CS"}, {"family": "Villar", "given": "Jes\u00fas", "initials": "J"}, {"family": "Ware", "given": "Lorraine B", "initials": "LB"}, {"family": "Weiss", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Zampieri", "given": "Fernando G", "initials": "FG"}, {"family": "Azoulay", "given": "Elie", "initials": "E"}, {"family": "Cecconi", "given": "Maurizio", "initials": "M"}, {"family": "European Society of Intensive Care Medicine Taskforce on ARDS", "given": "", "initials": ""}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "issn-l": "0342-4642", "volume": "49", "issue": "7", "pages": "727-759"}, "abstract": "The aim of these guidelines is to update the 2017 clinical practice guideline (CPG) of the European Society of Intensive Care Medicine (ESICM). The scope of this CPG is limited to adult patients and to non-pharmacological respiratory support strategies across different aspects of acute respiratory distress syndrome (ARDS), including ARDS due to coronavirus disease 2019 (COVID-19). These guidelines were formulated by an international panel of clinical experts, one methodologist and patients' representatives on behalf of the ESICM. The review was conducted in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement recommendations. We followed the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to assess the certainty of evidence and grade recommendations and the quality of reporting of each study based on the EQUATOR (Enhancing the QUAlity and Transparency Of health Research) network guidelines. The CPG addressed 21 questions and formulates 21 recommendations on the following domains: (1) definition; (2) phenotyping, and respiratory support strategies including (3) high-flow nasal cannula oxygen (HFNO); (4) non-invasive ventilation (NIV); (5) tidal volume setting; (6) positive end-expiratory pressure (PEEP) and recruitment maneuvers (RM); (7) prone positioning; (8) neuromuscular blockade, and (9) extracorporeal life support (ECLS). In addition, the CPG includes expert opinion on clinical practice and identifies the areas of future research.", "doi": "10.1007/s00134-023-07050-7", "pmid": "37326646", "labels": {"Category: Health": null, "Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10354163"}, {"db": "pii", "key": "10.1007/s00134-023-07050-7"}], "notes": [], "created": "2023-10-04T09:33:16.169Z", "modified": "2023-10-04T11:21:30.227Z"}, {"entity": "publication", "iuid": "2c8feac8e069488c974dd20db5646552", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c8feac8e069488c974dd20db5646552.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c8feac8e069488c974dd20db5646552"}}, "title": "Does misclassification of former tobacco smokers explain the 'smoker's paradox' in the risk of COVID-19? Insights from the Stockholm Public Health Cohort.", "authors": [{"family": "Shaaban", "given": "Ahmed N", "initials": "AN", "orcid": "0000-0001-8483-638X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b418a223c2054c459cc35896e4ee98db.json"}}, {"family": "Andersson", "given": "Filip", "initials": "F"}, {"family": "Magnusson", "given": "Cecilia", "initials": "C"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}, {"family": "Caspersen", "given": "Ida H", "initials": "IH"}, {"family": "Pe\u00f1a", "given": "Sebastian", "initials": "S"}, {"family": "Karvonen", "given": "Sakari", "initials": "S"}, {"family": "Magnus", "given": "Per", "initials": "P"}, {"family": "Galanti", "given": "Maria R", "initials": "MR", "orcid": "0000-0002-7805-280X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8bc2f32ea87d4ddc9710aad0834aafc5.json"}}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": "51", "issue": "5", "pages": "735-743"}, "abstract": "The association between tobacco smoking and the risk of COVID-19 and its adverse outcomes is controversial, as studies reported contrasting findings. Bias due to misclassification of the exposure in the analyses of current versus non-current smoking could be a possible explanation because former smokers may have higher background risks of the disease due to co-morbidity. The aim of the study was to investigate the extent of this potential bias by separating non-, former, and current smokers when assessing the risk or prognosis of diseases.\r\n\r\nWe analysed data from 43,400 participants in the Stockholm Public Health Cohort, Sweden, with information on smoking obtained prior to the pandemic. We estimated the risk of COVID-19, hospital admissions and death for (a) former and current smokers relative to non-smokers, (b) current smokers relative to non-current smokers, that is, including former smokers; adjusting for potential confounders (aRR).\r\n\r\nThe aRR of a COVID-19 diagnosis was elevated for former smokers compared with non-smokers (1.07; 95% confidence interval (CI) =1.00-1.15); including hospital admission with any COVID-19 diagnosis (aRR= 1.23; 95% CI = 1.03-1.48); or with COVID-19 as the main diagnosis (aRR=1.23, 95% CI= 1.01-1.49); and death within 30 days with COVID-19 as the main or a contributory cause (aRR=1.40; 95% CI=1.00-1.95). Current smoking was negatively associated with risk of COVID-19 (aRR=0.79; 95% CI=0.68-0.91).\r\n\r\nSeparating non-smokers from former smokers when assessing the disease risk or prognosis is essential to avoid bias. However, the negative association between current smoking and the risk of COVID-19 could not be entirely explained by misclassification.", "doi": "10.1177/14034948231174279", "pmid": "37165603", "labels": {"Category: Public Health": null, "Funder: NordForsk": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10183343"}], "notes": [], "created": "2023-10-04T05:09:46.201Z", "modified": "2023-10-04T06:08:29.155Z"}, {"entity": "publication", "iuid": "3dd75d5ee69a4397abe43b08a078fe21", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3dd75d5ee69a4397abe43b08a078fe21.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3dd75d5ee69a4397abe43b08a078fe21"}}, "title": "Cost Effectiveness of Strategies for Caring for Critically Ill Patients with COVID-19 in Tanzania.", "authors": [{"family": "Shah", "given": "Hiral Anil", "initials": "HA", "orcid": "0000-0003-0204-451X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21ddc194342b4a8280e1c0977ced1d43.json"}}, {"family": "Baker", "given": "Tim", "initials": "T", "orcid": "0000-0001-8727-7018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1454fc20049b4d47865268adf16d104a.json"}}, {"family": "Schell", "given": "Carl Otto", "initials": "CO", "orcid": "0000-0002-7904-1336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a40b337b45b471d97a102c355c9d874.json"}}, {"family": "Kuwawenaruwa", "given": "August", "initials": "A", "orcid": "0000-0001-8459-443X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cbb1004e55d04aa6831d0f1ac9c51233.json"}}, {"family": "Awadh", "given": "Khamis", "initials": "K"}, {"family": "Khalid", "given": "Karima", "initials": "K", "orcid": "0000-0001-9917-9853", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7c34a2daebf4e0483d0de27357ce4db.json"}}, {"family": "Kairu", "given": "Angela", "initials": "A", "orcid": "0000-0002-0965-4460", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/655a16b5d0704794a9183726b74eee30.json"}}, {"family": "Were", "given": "Vincent", "initials": "V", "orcid": "0000-0002-3554-795X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59d578f5fe6d4fa0b015dc1fd609c932.json"}}, {"family": "Barasa", "given": "Edwine", "initials": "E", "orcid": "0000-0001-5793-7177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0487b77768174459af77fa6456cf5954.json"}}, {"family": "Baker", "given": "Peter", "initials": "P", "orcid": "0000-0001-9028-9976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/117923062b604fc0b2206c9adeef38b1.json"}}, {"family": "Guinness", "given": "Lorna", "initials": "L", "orcid": "0000-0002-1013-4200", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bf8da5dd3e24b669b1f58ea651be77a.json"}}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Pharmacoecon Open", "issn": "2509-4254", "issn-l": null, "volume": "7", "issue": "4", "pages": "537-552"}, "abstract": "The resources for critical care are limited in many settings, exacerbating the significant morbidity and mortality associated with critical illness. Budget constraints can lead to choices between investing in advanced critical care (e.g. mechanical ventilators in intensive care units) or more basic critical care such as Essential Emergency and Critical Care (EECC; e.g. vital signs monitoring, oxygen therapy, and intravenous fluids).\r\n\r\nWe investigated the cost effectiveness of providing EECC and advanced critical care in Tanzania in comparison with providing 'no critical care' or 'district hospital-level critical care' using coronavirus disease 2019 (COVID-19) as a tracer condition. We developed an open-source Markov model ( https://github.com/EECCnetwork/POETIC_CEA ) to estimate costs and disability-adjusted life-years (DALYs) averted, using a provider perspective, a 28-day time horizon, patient outcomes obtained from an elicitation method involving a seven-member expert group, a normative costing study, and published literature. We performed a univariate and probabilistic sensitivity analysis to assess the robustness of our results.\r\n\r\nEECC is cost effective 94% and 99% of the time when compared with no critical care (incremental cost-effectiveness ratio [ICER] $37 [-$9 to $790] per DALY averted) and district hospital-level critical care (ICER $14 [-$200 to $263] per DALY averted), respectively, relative to the lowest identified estimate of the willingness-to-pay threshold for Tanzania ($101 per DALY averted). Advanced critical care is cost effective 27% and 40% of the time, when compared with the no critical care or district hospital-level critical care scenarios, respectively.\r\n\r\nFor settings where there is limited or no critical care delivery, implementation of EECC could be a highly cost-effective investment. It could reduce mortality and morbidity for critically ill COVID-19 patients, and its cost effectiveness falls within the range considered 'highly cost effective'. Further research is needed to explore the potential of EECC to generate even greater benefits and value for money when patients with diagnoses other than COVID-19 are accounted for.", "doi": "10.1007/s41669-023-00418-x", "pmid": "37178434", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10181924"}, {"db": "pii", "key": "10.1007/s41669-023-00418-x"}], "notes": [], "created": "2023-10-04T05:11:10.509Z", "modified": "2023-10-04T07:08:57.586Z"}, {"entity": "publication", "iuid": "08c5680512c54af484164d9feb458e04", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/08c5680512c54af484164d9feb458e04.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/08c5680512c54af484164d9feb458e04"}}, "title": "Association between hypersomnolence and the COVID-19 pandemic: The International COVID-19 Sleep Study (ICOSS).", "authors": [{"family": "Sarkanen", "given": "Tomi", "initials": "T"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Merikanto", "given": "Ilona", "initials": "I"}, {"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Nadorff", "given": "Michael R", "initials": "MR"}, {"family": "Bolstad", "given": "Courtney J", "initials": "CJ"}, {"family": "Espie", "given": "Colin", "initials": "C"}, {"family": "Matsui", "given": "Kentaro", "initials": "K"}, {"family": "Chung", "given": "Frances", "initials": "F"}, {"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK"}, {"family": "Penzel", "given": "Thomas", "initials": "T"}, {"family": "Mac\u00eado", "given": "Tain\u00e1", "initials": "T"}, {"family": "Mota-Rolim", "given": "S\u00e9rgio", "initials": "S"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Plazzi", "given": "Giuseppe", "initials": "G"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L"}, {"family": "Landtblom", "given": "Anne-Marie", "initials": "A"}, {"family": "Inoue", "given": "Yuichi", "initials": "Y"}, {"family": "Sieminski", "given": "Mariuz", "initials": "M"}, {"family": "Leger", "given": "Damien", "initials": "D"}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y"}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Sleep Med", "issn": "1878-5506", "issn-l": null, "volume": "107", "issue": null, "pages": "108-115"}, "abstract": "The COVID-19 pandemic and related restriction measures have affected our daily life, sleep, and circadian rhythms worldwide. Their effects on hypersomnolence and fatigue remain unclear.\r\n\r\nThe International COVID-19 Sleep Study questionnaire which included items on hypersomnolence such as excessive daytime sleepiness (EDS), and excessive quantity of sleep (EQS), as well as sociodemographic factors, sleep patterns, psychological symptoms, and quality of life was distributed in 15 countries across the world from May to September in 2020.\r\n\r\nAltogether responses from 18,785 survey participants (65% women, median age 39 years) were available for analysis. Only 2.8% reported having had COVID-19. Compared to before the pandemic, the prevalence of EDS, EQS, and fatigue increased from 17.9% to 25.5%, 1.6%-4.9%, and 19.4%-28.3% amid the pandemic, respectively. In univariate logistic regression models, reports of having a COVID-19 were associated with EQS (OR 5.3; 95%-CI 3.6-8.0), EDS (2.6; 2.0-3.4), and fatigue (2.8; 2.1-3.6). In adjusted multivariate logistic regression, sleep duration shorter than desired (3.9; 3.2-4.7), depressive symptoms (3.1; 2.7-3.5), use of hypnotics (2.3; 1.9-2.8), and having reported COVID-19 (1.9; 1.3-2.6) remained strong predictors of EDS. Similar associations emerged for fatigue. In the multivariate model, depressive symptoms (4.1; 3.6-4.6) and reports of having COVID-19 (2.0; 1.4-2.8) remained associated with EQS.\r\n\r\nA large increase in EDS, EQS, and fatigue occurred due to the COVID-19 pandemic, and especially in self-reported cases of COVID-19. These findings warrant a thorough understanding of their pathophysiology to target prevention and treatment strategies for long COVID condition.", "doi": "10.1016/j.sleep.2023.04.024", "pmid": "37156053", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10163923"}, {"db": "pii", "key": "S1389-9457(23)00160-0"}], "notes": [], "created": "2023-10-04T05:10:28.509Z", "modified": "2023-10-04T06:43:00.331Z"}, {"entity": "publication", "iuid": "49656b81c61e436191b96dbd34ab2c02", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49656b81c61e436191b96dbd34ab2c02.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49656b81c61e436191b96dbd34ab2c02"}}, "title": "Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia in middle-income countries.", "authors": [{"family": "van de Munckhof", "given": "Anita", "initials": "A", "orcid": "0000-0001-6028-3426", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e0cc819c9fe4a0b89beb8c30ea0b6b6.json"}}, {"family": "Borhani-Haghighi", "given": "Afshin", "initials": "A", "orcid": "0000-0002-4131-7990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f8cc4b1e730435092ab97b92bbe4d36.json"}}, {"family": "Aaron", "given": "Sanjith", "initials": "S", "orcid": "0000-0002-5151-1500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98fdfb1034344016b5f0c16e10963382.json"}}, {"family": "Krzywicka", "given": "Katarzyna", "initials": "K"}, {"family": "van Kammen", "given": "Mayte S\u00e1nchez", "initials": "MS"}, {"family": "Cordonnier", "given": "Charlotte", "initials": "C"}, {"family": "Kleinig", "given": "Timothy J", "initials": "TJ"}, {"family": "Field", "given": "Thalia S", "initials": "TS", "orcid": "0000-0002-1176-0633", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f08f5ddffb74ae796f60cdf39b3ef8c.json"}}, {"family": "Poli", "given": "Sven", "initials": "S", "orcid": "0000-0002-0286-8781", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c953f4fa37054db9b0ea7127a5593847.json"}}, {"family": "Lemmens", "given": "Robin", "initials": "R"}, {"family": "Scutelnic", "given": "Adrian", "initials": "A"}, {"family": "Lindgren", "given": "Erik", "initials": "E"}, {"family": "Duan", "given": "Jiangang", "initials": "J"}, {"family": "Arslan", "given": "Y\u0131ld\u0131z", "initials": "Y"}, {"family": "van Gorp", "given": "Eric Cm", "initials": "EC"}, {"family": "Kremer Hovinga", "given": "Johanna A", "initials": "JA"}, {"family": "G\u00fcnther", "given": "Albrecht", "initials": "A"}, {"family": "Jood", "given": "Katarina", "initials": "K"}, {"family": "Tatlisumak", "given": "Turgut", "initials": "T"}, {"family": "Putaala", "given": "Jukka", "initials": "J"}, {"family": "Heldner", "given": "Mirjam R", "initials": "MR"}, {"family": "Arnold", "given": "Marcel", "initials": "M"}, {"family": "de Sousa", "given": "Diana Aguiar", "initials": "DA", "orcid": "0000-0002-6702-7924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cc3515119a247859fe1fea025f703ef.json"}}, {"family": "Wasay", "given": "Mohammad", "initials": "M", "orcid": "0000-0003-3750-2613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d31625317cd48779278fb20fee594a8.json"}}, {"family": "Arauz", "given": "Antonio", "initials": "A"}, {"family": "Conforto", "given": "Adriana Bastos", "initials": "AB"}, {"family": "Ferro", "given": "Jos\u00e9 M", "initials": "JM", "orcid": "0000-0002-2343-9097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c8285bcf71c4ed1aa7b57a13c5cb70a.json"}}, {"family": "Coutinho", "given": "Jonathan M", "initials": "JM"}, {"family": "Cerebral Venous Sinus Thrombosis with Thrombocytopenia Syndrome Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-06-30", "journal": {"title": "Int J Stroke", "issn": "1747-4949", "issn-l": null, "volume": null, "issue": null, "pages": "17474930231182901"}, "abstract": "Adenovirus-based COVID-19 vaccines are extensively used in low- and middle-income countries (LMICs). Remarkably, cases of cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) have rarely been reported from LMICs.\r\n\r\nWe studied the frequency, manifestations, treatment, and outcomes of CVST-VITT in LMICs.\r\n\r\nWe report data from an international registry on CVST after COVID-19 vaccination. VITT was classified according to the Pavord criteria. We compared CVST-VITT cases from LMICs to cases from high-income countries (HICs).\r\n\r\nUntil August 2022, 228 CVST cases were reported, of which 63 were from LMICs (all middle-income countries [MICs]: Brazil, China, India, Iran, Mexico, Pakistan, Turkey). Of these 63, 32 (51%) met the VITT criteria, compared to 103 of 165 (62%) from HICs. Only 5 of the 32 (16%) CVST-VITT cases from MICs had definite VITT, mostly because anti-platelet factor 4 antibodies were often not tested. The median age was 26 (interquartile range [IQR] 20-37) versus 47 (IQR 32-58) years, and the proportion of women was 25 of 32 (78%) versus 77 of 103 (75%) in MICs versus HICs, respectively. Patients from MICs were diagnosed later than patients from HICs (1/32 [3%] vs. 65/103 [63%] diagnosed before May 2021). Clinical manifestations, including intracranial hemorrhage, were largely similar as was intravenous immunoglobulin use. In-hospital mortality was lower in MICs (7/31 [23%, 95% confidence interval (CI) 11-40]) than in HICs (44/102 [43%, 95% CI 34-53], p = 0.039).\r\n\r\nThe number of CVST-VITT cases reported from LMICs was small despite the widespread use of adenoviral vaccines. Clinical manifestations and treatment of CVST-VITT cases were largely similar in MICs and HICs, while mortality was lower in patients from MICs.", "doi": "10.1177/17474930231182901", "pmid": "37277922", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:32:36.532Z", "modified": "2023-10-04T11:12:08.100Z"}, {"entity": "publication", "iuid": "b5297743cde049d68ec810db8b68c822", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5297743cde049d68ec810db8b68c822.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5297743cde049d68ec810db8b68c822"}}, "title": "Post-COVID sequelae effect in chronic fatigue syndrome: SARS-CoV-2 triggers latent adenovirus in the oral mucosa.", "authors": [{"family": "Hannestad", "given": "Ulf", "initials": "U"}, {"family": "Apostolou", "given": "Eirini", "initials": "E"}, {"family": "Sj\u00f6gren", "given": "Per", "initials": "P"}, {"family": "Brag\u00e9e", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Polo", "given": "Olli", "initials": "O"}, {"family": "Bertilson", "given": "Bo Christer", "initials": "BC"}, {"family": "Ros\u00e9n", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2023-06-29", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "issn-l": null, "volume": "10", "issue": null, "pages": "1208181"}, "abstract": "The post-viral fatigue syndromes long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have multiple, potentially overlapping, pathological processes. These include persisting reservoirs of virus, e.g., SARS-CoV-2 in long COVID patient's tissues, immune dysregulation with or without reactivation of underlying pathogens, such as Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV6), as we recently described in ME/CFS, and possibly yet unidentified viruses. In the present study we tested saliva samples from two cohorts for IgG against human adenovirus (HAdV): patients with ME/CFS (n = 84) and healthy controls (n = 94), with either mild/asymptomatic SARS-CoV-2 infection or no infection. A significantly elevated anti-HAdV IgG response after SARS-CoV-2 infection was detected exclusively in the patient cohort. Longitudinal/time analysis, before and after COVID-19, in the very same individuals confirmed HAdV IgG elevation after. In plasma there was no HAdV IgG elevation. We conclude that COVID-19 triggered reactivation of dormant HAdV in the oral mucosa of chronic fatigue patients indicating an exhausted dysfunctional antiviral immune response in ME/CFS, allowing reactivation of adenovirus upon stress encounter such as COVID-19. These novel findings should be considered in clinical practice for identification of patients that may benefit from therapy that targets HAdV as well.", "doi": "10.3389/fmed.2023.1208181", "pmid": "37457558", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC10349329"}], "notes": [], "created": "2023-10-04T12:07:38.054Z", "modified": "2023-10-04T12:21:18.720Z"}, {"entity": "publication", "iuid": "3fa5cfcbec3f42e798406ff5e9e3d1d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3fa5cfcbec3f42e798406ff5e9e3d1d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3fa5cfcbec3f42e798406ff5e9e3d1d9"}}, "title": "One year safety and immunogenicity of AZD1222 (ChAdOx1 nCoV-19): Final analysis of a randomized, placebo-controlled phase 1/2 trial in Japan.", "authors": [{"family": "Ishikawa", "given": "Kensuke", "initials": "K"}, {"family": "Nascimento", "given": "Maria-Claudia", "initials": "M"}, {"family": "Asano", "given": "Michiko", "initials": "M"}, {"family": "Hirata", "given": "Hajime", "initials": "H"}, {"family": "Itoh", "given": "Yohji", "initials": "Y"}, {"family": "Kelly", "given": "Elizabeth J", "initials": "EJ"}, {"family": "Matsui", "given": "Akiko", "initials": "A"}, {"family": "Olsson", "given": "Urban", "initials": "U"}, {"family": "Shoemaker", "given": "Kathryn", "initials": "K"}, {"family": "Green", "given": "Justin", "initials": "J"}], "type": "randomized controlled trial", "published": "2023-06-29", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null, "volume": "41", "issue": "29", "pages": "4199-4205"}, "abstract": "Long duration trial data for two-dose COVID-19 vaccines primary series' are uncommon due to unblinding and additional doses. We report one-year follow-up results from a phase 1/2 trial of AZD1222 (ChAdOx1 nCoV-19) in Japan.\r\n\r\nAdults (n = 256) seronegative for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) were stratified by age, 18-55 (n = 128), 56-69 (n = 86) and \u226570-year-old (n = 42), and randomized 3:1 to AZD1222 or placebo. Safety, immunogenicity, and exploratory efficacy data were collected until study Day 365.\r\n\r\nSafety was consistent with previous reports. In AZD1222 vaccinees, humoral responses against SARS-CoV-2 steadily declined over time. By Day 365, anti-SARS-CoV-2 spike-binding (spike) and receptor-binding domain (RBD) mean antibody titers remained above Day 15 levels and pseudovirus neutralizing antibodies were undetectable in many participants.\r\n\r\nAZD1222 is immunogenic and well tolerated in Japanese adults. Expected waning in anti-SARS-CoV-2 humoral responses was observed; spike and RBD antibody titers remained elevated. (ClinicalTrials.gov: NCT04568031).", "doi": "10.1016/j.vaccine.2023.05.015", "pmid": "37271703", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10237326"}, {"db": "pii", "key": "S0264-410X(23)00542-X"}, {"db": "ClinicalTrials.gov", "key": "NCT04568031"}], "notes": [], "created": "2023-10-04T09:30:12.084Z", "modified": "2023-10-04T09:51:35.301Z"}, {"entity": "publication", "iuid": "cca3bfbe17894d229c006db8e4a464d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cca3bfbe17894d229c006db8e4a464d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cca3bfbe17894d229c006db8e4a464d7"}}, "title": "Changes in trauma-related emergency medical services during the COVID-19 lockdown in the Western Cape, South Africa.", "authors": [{"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Stassen", "given": "Willem", "initials": "W"}, {"family": "Laflamme", "given": "Lucie", "initials": "L"}, {"family": "Wallis", "given": "Lee Alan", "initials": "LA"}, {"family": "Hasselberg", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2023-06-27", "journal": {"title": "BMC Emerg Med", "issn": "1471-227X", "issn-l": null, "volume": "23", "issue": "1", "pages": "72"}, "abstract": "To limit virus spread during the COVID pandemic, extensive measures were implemented around the world. In South Africa, these restrictions included alcohol and movement restrictions, factors previously linked to injury burden in the country. Consequently, reports from many countries, including South Africa, have shown a reduction in trauma presentations related to these restrictions. However, only few studies and none from Africa focus on the impact of the pandemic restrictions on the Emergency Medical System (EMS).\r\n\r\nWe present a retrospective, observational longitudinal study including data from all ambulance transports of physical trauma cases collected during the period 2019-01-01 and 2021-02-28 from the Western Cape Government EMS in the Western Cape Province, South Africa (87,167 cases). Within this timeframe, the 35-days strictest lockdown level period was compared to a 35-days period prior to the lockdown and to the same 35-days period in 2019. Injury characteristics (intent, mechanism, and severity) and time were studied in detail. Ambulance transport volumes as well as ambulance response and on-scene time before and during the pandemic were compared. Significance between indicated periods was determined using Chi-square test.\r\n\r\nDuring the strictest lockdown period, presentations of trauma cases declined by > 50%. Ambulance transport volumes decreased for all injury mechanisms and proportions changed. The share of assaults and traffic injuries decreased by 6% and 8%, respectively, while accidental injuries increased by 5%. The proportion of self-inflicted injuries increased by 5%. Studies of injury time showed an increased share of injuries during day shift and a reduction of total injury volume during the weekend during the lockdown. Median response- and on-scene time remained stable in the time-periods studied.\r\n\r\nThis is one of the first reports on the influence of COVID-19 related restrictions on EMS, and the first in South Africa. We report a decline in trauma related ambulance transport volumes in the Western Cape Province as well as changes in injury patterns, largely corresponding to previous findings from hospital settings in South Africa. The unchanged response and on-scene times indicate a well-functioning EMS despite pandemic challenges. More studies are needed, especially disaggregating the different restrictions.", "doi": "10.1186/s12873-023-00840-8", "pmid": "37370047", "labels": {"Category: Health": null, "Category: Other": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10304331"}, {"db": "pii", "key": "10.1186/s12873-023-00840-8"}], "notes": [], "created": "2023-10-04T09:33:06.004Z", "modified": "2023-10-04T11:16:08.902Z"}, {"entity": "publication", "iuid": "2b0291b59f914953869fbec4b66b3bd4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b0291b59f914953869fbec4b66b3bd4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b0291b59f914953869fbec4b66b3bd4"}}, "title": "Students at a crossroad: A cross-sectional survey gauging the impact of COVID-19 on medical and biomedical graduates in the United States and Sweden.", "authors": [{"family": "Lange", "given": "Stephan", "initials": "S", "orcid": "0000-0001-9361-6602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d15f59268b2e47c58612b025e48707bb.json"}}, {"family": "Sot\u00e1k", "given": "Mat\u00fa\u0161", "initials": "M", "orcid": "0000-0002-9984-9340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/238be0180b0f499f9eb0fe69d7b0389a.json"}}, {"family": "Hagberg", "given": "Carolina E", "initials": "CE"}, {"family": "Bagunu", "given": "Grace", "initials": "G"}, {"family": "Vigmo", "given": "Sylvi", "initials": "S"}, {"family": "B\u00f6rgeson", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2023-06-24", "journal": {"title": "Biochem Mol Biol Educ", "issn": "1539-3429", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Graduate programs in medicine and biomedical sciences have been severely impacted by the SARS-CoV-2/COVID-19 pandemic over the last 2 years. Following 2 years since beginning of the pandemic, data on student support, educational and academic performance as well as sentiment on changes to educational programs are starting to emerge. We performed and compared results of two cross-sectional surveys of Swedish and U.S.-based medical and biomedical graduate students on how the pandemic has affected their studies, research productivity and career trajectory. Students were also asked to assess support provided by the university and supervisors. The surveys also captured student demographics and a range of other factors, such as pressures brought on by caretaking and financial responsibilities. We analyzed answers from 264 and 106 students attending graduate programs in universities in Sweden and the United States, respectively. U.S.-based students faced more severe restrictions on their research program compared to students in Sweden, reporting more delays in productivity, scientific output and graduation, and increased worries about their career trajectory. Swedish students had more caretaking responsibilities, although these did not cause any delays in graduation. While support by universities and supervisors was comparable between the countries, financial worries and mental health concerns were particularly prominent in the U.S. cohort. Student performance and outlook was hugely dependent on the breadth of the restrictions and the available support. Besides the governmental and university-led approach to counter the pandemic, societal differences also played a role in how well students were handling effects of the pandemic.", "doi": "10.1002/bmb.21761", "pmid": "37354049", "labels": {"Category: Social Science & Humanities": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:30:48.915Z", "modified": "2023-10-04T10:05:44.722Z"}, {"entity": "publication", "iuid": "a9ee88d043544386b7c7616bb638f012", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a9ee88d043544386b7c7616bb638f012.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a9ee88d043544386b7c7616bb638f012"}}, "title": "Patient reported experiences of Swedish patients being investigated for cancer during the Covid-19 pandemic.", "authors": [{"family": "Tufvesson Stiller", "given": "Helena", "initials": "H", "orcid": "0000-0001-5213-9555", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9e04f2b00a5436192e564e3b0af08cb.json"}}, {"family": "Schmitt-Egenolf", "given": "Marcus", "initials": "M", "orcid": "0000-0002-3858-8474", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84d3fdbf4946483b9651365b34f2333e.json"}}, {"family": "Fohlin", "given": "Helena", "initials": "H", "orcid": "0000-0003-4336-0949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/142b56d58aec4dfab0f217cb3e334a52.json"}}, {"family": "Uppugunduri", "given": "Srinivas", "initials": "S", "orcid": "0000-0003-0572-5580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e6b350c35264d8db2606af67303deed.json"}}], "type": "journal article", "published": "2023-06-24", "journal": {"title": "Support Care Cancer", "issn": "1433-7339", "issn-l": null, "volume": "31", "issue": "7", "pages": "416"}, "abstract": "Patient reported experiences in individuals being investigated for cancer have been recorded in a nationwide survey in Sweden, providing an opportunity to assess the impact of the Covid-19-pandemic.\r\n\r\nQuestionnaires from 45920 patients were analyzed to assess the experience of being investigated for cancer. Data from before the Covid-19-pandemic (2018-2019) was compared to data acquired during the pandemic (2020-2021), using chi-square and Wilcoxon rank sum tests. Both, patients who were cleared from suspicion of cancer and those who were diagnosed with cancer were included.\r\n\r\nFewer patients in total visited health services during the pandemic. However, patients that did seek help did so to a similar extent during as prior to the pandemic. Patient waiting time was perceived to be shorter during the pandemic and judged as neither too long nor too short by most patients. The emotional support to patients improved during the pandemic, whereas the support to next of kin declined. A majority of patients received the results from the investigation in a meeting with the physician. Although there was a preference for receiving results in a meeting with the physician, the pandemic has brought an increasing interest in receiving results by phone.\r\n\r\nSwedish cancer healthcare has shown resilience during the Covid-19-pandemic, maintaining high patient satisfaction while working under conditions of extraordinary pressure. Patients became more open to alternatives to physical \"in person\" health care visits which could lead to more digital visits in the future. However, support to significant others demands special attention.", "doi": "10.1007/s00520-023-07897-y", "pmid": "37354327", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10290588"}, {"db": "pii", "key": "10.1007/s00520-023-07897-y"}], "notes": [], "created": "2023-10-04T09:31:03.603Z", "modified": "2023-10-04T10:41:54.531Z"}, {"entity": "publication", "iuid": "b574a09ae6e4410d84166c128e63fc42", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b574a09ae6e4410d84166c128e63fc42.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b574a09ae6e4410d84166c128e63fc42"}}, "title": "Pulmonary embolism and deep venous thrombosis after COVID-19: long-term risk in a population-based cohort study.", "authors": [{"family": "Sjoland", "given": "Helen", "initials": "H"}, {"family": "Lindgren", "given": "Martin", "initials": "M"}, {"family": "Toska", "given": "Triantafyllia", "initials": "T"}, {"family": "Hansson", "given": "Per-Olof", "initials": "P"}, {"family": "Sandblad", "given": "Katarina Glise", "initials": "KG"}, {"family": "Alex", "given": "Christian", "initials": "C"}, {"family": "Bjorck", "given": "Lena", "initials": "L"}, {"family": "Cronie", "given": "Ottmar", "initials": "O"}, {"family": "Bjork", "given": "Jonas", "initials": "J"}, {"family": "Lundberg", "given": "Christina E", "initials": "CE"}, {"family": "Adiels", "given": "Martin", "initials": "M"}, {"family": "Rosengren", "given": "Annika", "initials": "A"}], "type": "journal article", "published": "2023-06-21", "journal": {"title": "Res Pract Thromb Haemost", "issn": "2475-0379", "issn-l": null, "volume": "7", "issue": "5", "pages": "100284"}, "abstract": "Venous thromboembolism (VTE) (pulmonary embolism (PE) or deep venous thrombosis (DVT)) is common during acute COVID-19. Long-term excess risk has not yet been established.\r\n\r\nTo study long-term VTE risk after COVID-19.\r\n\r\nSwedish citizens aged 18-84 years, hospitalized and/or testing positive for COVID-19 between January 1, 2020, and September 11, 2021 (exposed), stratified by initial hospitalization, were compared to matched (1:5) non-exposed population-derived subjects without COVID-19. Outcomes were incident VTE, PE or DVT recorded within 60, 60-<180, and \u2265180 days. Cox regression was used for evaluation and a model adjusted for age, sex, comorbidities and socioeconomic markers developed to control for confounders.\r\n\r\nAmong exposed patients, 48,861 were hospitalized for COVID-19 (mean age 60.6 years) and 894,121 were without hospitalization (mean age 41.4 years). Among patients hospitalized for COVID-19, fully adjusted hazard ratios (HRs) during 60-<180 days were 6.05 (95% confidence interval (CI) 4.80\u25007.62) for PE and 3.97 (CI 2.96\u25005.33) for DVT, compared to non-exposed with corresponding estimates among COVID-19 without hospitalization 1.17 (CI 1.01\u25001.35) and 0.99 (CI 0.86\u25001.15), based on 475 and 2,311 VTE events, respectively. Long-term (\u2265180 days) HRs in patients hospitalized for COVID-19 were 2.01 (CI 1.51\u25002.68) for PE and 1.46 (CI 1.05\u25002.01) for DVT while non-hospitalized had similar risk to non-exposed, based on 467 and 2,030 VTE events, respectively.\r\n\r\nPatients hospitalized for COVID-19 retained an elevated excess risk of VTE, mainly PE, after 180 days, while long-term risk of VTE in individuals with COVID-19 without hospitalization was similar to the non-exposed.", "doi": "10.1016/j.rpth.2023.100284", "pmid": "37361398", "labels": {"Category: Health": null, "Category: Post-COVID": null, "Funder: VR": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10284449"}, {"db": "pii", "key": "S2475-0379(23)00184-X"}], "notes": [], "created": "2023-10-04T09:30:14.456Z", "modified": "2023-10-04T09:52:58.203Z"}, {"entity": "publication", "iuid": "9045fd55bc8e4a38aea3884a3373343a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9045fd55bc8e4a38aea3884a3373343a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9045fd55bc8e4a38aea3884a3373343a"}}, "title": "COVID-19-related stigma among infected people in Sweden; psychometric properties and levels of stigma in two cohorts as measured by a COVID-19 stigma scale.", "authors": [{"family": "Reinius", "given": "Maria", "initials": "M"}, {"family": "Svedhem", "given": "Veronica", "initials": "V"}, {"family": "Bruchfeld", "given": "Judith", "initials": "J"}, {"family": "Holmstr\u00f6m Larm", "given": "Heidi", "initials": "H"}, {"family": "Nygren-Bonnier", "given": "Malin", "initials": "M"}, {"family": "Eriksson", "given": "Lars E", "initials": "LE", "orcid": "0000-0001-5121-5325", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09bec95869bc450aa97e0aa11485807e.json"}}], "type": "journal article", "published": "2023-06-21", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "6", "pages": "e0287341"}, "abstract": "Epidemics have historically been accompanied by stigma and discrimination. Disease-related stigma has often been shown to have severe consequences for physical, mental and social wellbeing and lead to barriers to diagnosis, treatment and prevention. The aims of this study were to investigate if a HIV-related stigma measure could be adapted and valid and reliable to measure COVID-19-related stigma, and also to investigate levels of self-reported stigma and related factors among people in Sweden with experience of COVID-19 and compare levels of COVID-19-related stigma versus HIV-related stigma among persons living with HIV who had experienced a COVID-19 event.\r\n\r\nCognitive interviews (n = 11) and cross-sectional surveys were made after the acute phase of the illness using a new 12-item COVID-19 Stigma Scale and the established 12-item HIV Stigma Scale in two cohorts (people who had experienced COVID-19 (n = 166/209, 79%) and people living with HIV who had experienced a COVID-19 event (n = 50/91, 55%). Psychometric analysis of the COVID-19 Stigma Scale was performed by calculating floor and ceiling effects, Cronbach's \u03b1 and exploratory factor analysis. Levels of COVID-19 stigma between groups were analysed using the Mann-Whitney U test. Levels of COVID-19 and HIV stigma among people living with HIV with a COVID-19 event were compared using the Wilcoxon signed-rank test.\r\n\r\nThe COVID-19 cohort consisted of 88 (53%) men and 78 (47%) women, mean age 51 (19-80); 143 (87%) living in a higher and 22 (13%) in a lower income area. The HIV + COVID-19 cohort consisted of 34 (68%) men and 16 (32%) women, mean age 51 (26-79); 20 (40%) living in a higher and 30 (60%) in a lower income area. The cognitive interviews showed that the stigma items were easy to understand. Factor analysis suggested a four-factor solution accounting for 77% of the total variance. There were no cross loadings, but two items loaded on factors differing from the original scale. All subscales had acceptable internal consistency, showed high floor and no ceiling effects. There was no statistically significant difference between COVID-19 stigma scores between the two cohorts or between genders. People living in lower income areas reported more negative self-image and concerns about public attitudes related to COVID-19 than people in higher income areas (median score 3 vs 3 and 4 vs 3 on a scale from 3-12, Z = -1.980, p = 0.048 and Z = -2.023, p = 0.024, respectively). People from the HIV + COVID-19 cohort reported more HIV than COVID-19 stigma.\r\n\r\nThe adapted 12-item COVID-19 Stigma Scale may be valid and reliable for measurement of COVID-19-related stigma. However, specific items may need to be rephrased or replaced to better correspond to the COVID-19 context. People who had experienced COVID-19 reported low levels of COVID-19-related stigma in general but people from lower income areas had higher levels of negative self-image and concerns about public attitudes related to COVID-19 than people from areas with higher income, which may call for targeted interventions. Although exhibiting more pronounced HIV stigma levels, people living with HIV who had experienced COVID-19 reported COVID-19-related stigma of the same low magnitude as their peers not living with HIV.", "doi": "10.1371/journal.pone.0287341", "pmid": "37343027", "labels": {"Category: Social Science & Humanities": null, "Funder: VR": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10284413"}, {"db": "pii", "key": "PONE-D-22-35422"}], "notes": [], "created": "2023-10-04T09:30:07.232Z", "modified": "2023-10-04T09:48:40.291Z"}, {"entity": "publication", "iuid": "ae329cc718d04c629791e3fddd27d5ad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ae329cc718d04c629791e3fddd27d5ad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ae329cc718d04c629791e3fddd27d5ad"}}, "title": "Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity", "authors": [{"family": "Brunet-Ratnasingham", "given": "Elsa", "initials": "E", "orcid": "0000-0002-3613-1315", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae34faa98db04e62b0cdd39d9126b782.json"}}, {"family": "Morin", "given": "Sacha", "initials": "S"}, {"family": "Randolph", "given": "Haley E", "initials": "HE"}, {"family": "Labrecque", "given": "Marjorie", "initials": "M"}, {"family": "B\u00e9lair", "given": "Justin", "initials": "J"}, {"family": "Lima-Barbosa", "given": "Rapha\u00ebl", "initials": "R"}, {"family": "Pagliuzza", "given": "Am\u00e9lie", "initials": "A"}, {"family": "Marchitto", "given": "Lorie", "initials": "L"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Niessl", "given": "Julia", "initials": "J"}, {"family": "Cloutier", "given": "Rose", "initials": "R"}, {"family": "Sreng Flores", "given": "Alina M", "initials": "AM"}, {"family": "Brassard", "given": "Nathalie", "initials": "N"}, {"family": "Benlarbi", "given": "Mehdi", "initials": "M"}, {"family": "Pr\u00e9vost", "given": "J\u00e9r\u00e9mie", "initials": "J"}, {"family": "Ding", "given": "Shilei", "initials": "S"}, {"family": "Anand", "given": "Sai Priya", "initials": "SP"}, {"family": "Sannier", "given": "G\u00e9r\u00e9my", "initials": "G"}, {"family": "Bareke", "given": "Eric", "initials": "E"}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ee1510080704cf6a2a6972deb94123f.json"}}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Zhou", "given": "Sirui", "initials": "S"}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T", "orcid": "0000-0001-9510-5646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd273e50091d44c3b3e8d1473ce89b0a.json"}}, {"family": "Morrison", "given": "David", "initials": "D"}, {"family": "Vezina", "given": "Dani", "initials": "D"}, {"family": "Bourassa", "given": "Catherine", "initials": "C"}, {"family": "Gendron-Lepage", "given": "Gabrielle", "initials": "G"}, {"family": "Medjahed", "given": "Halima", "initials": "H"}, {"family": "Point", "given": "Floriane", "initials": "F"}, {"family": "Richard", "given": "Jonathan", "initials": "J"}, {"family": "Larochelle", "given": "Catherine", "initials": "C"}, {"family": "Prat", "given": "Alexandre", "initials": "A"}, {"family": "Arbour", "given": "Nathalie", "initials": "N"}, {"family": "Durand", "given": "Madeleine", "initials": "M"}, {"family": "Brent Richards", "given": "J", "initials": "J"}, {"family": "Moon", "given": "Kevin", "initials": "K"}, {"family": "Chomont", "given": "Nicolas", "initials": "N", "orcid": "0000-0001-9747-5018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/477cede6c34e4908a8e806f6352d3daa.json"}}, {"family": "Finzi", "given": "Andr\u00e9s", "initials": "A"}, {"family": "T\u00e9treault", "given": "Martine", "initials": "M"}, {"family": "Barreiro", "given": "Luis", "initials": "L"}, {"family": "Wolf", "given": "Guy", "initials": "G"}, {"family": "Kaufmann", "given": "Daniel E", "initials": "DE", "orcid": "0000-0003-4467-136X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9581da3f05024ef68e4ded53cb9b413c.json"}}], "type": "posted-content", "published": "2023-06-20", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.06.14.23290814", "pmid": null, "labels": {"Funder: VR": null, "Category: Genomics & transcriptomics": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Preprint": null, "Category: Serology": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:30:00.232Z", "modified": "2023-10-04T09:44:01.052Z"}, {"entity": "publication", "iuid": "4b5a011592d14e78a026c78150d0dd7b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b5a011592d14e78a026c78150d0dd7b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b5a011592d14e78a026c78150d0dd7b"}}, "title": "Lessons learned from pandemic response to COVID-19 in Bangladesh: NGO-based emergency response framework for low- and middle-income countries.", "authors": [{"family": "Ahmed", "given": "Tanvir", "initials": "T", "orcid": "0000-0001-8147-5136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f6ebfebcb3a40128282c0fe6bf61720.json"}}, {"family": "Musarrat", "given": "Parsa", "initials": "P", "orcid": "0000-0002-4210-5228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c80b1a7a9ea4952bf1b7653121b0e4f.json"}}, {"family": "Kabir", "given": "Zarina Nahar", "initials": "ZN", "orcid": "0000-0003-0465-5701", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7e6bafbfd6843e188acefca5ce929b1.json"}}], "type": "journal article", "published": "2023-06-20", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "issn-l": null, "volume": "23", "issue": "1", "pages": "656"}, "abstract": "Response to COVID-19 pandemic in Bangladesh was led by the Government of Bangladesh aided by Non-Government Organisations (NGO) among others. The aim of the study was to explore the activities of such an NGO to understand the philosophy, aspiration and strategy to plan and implement an effective response to COVID-19 pandemic in Bangladesh.\r\n\r\nA case study of a Bangladeshi NGO called SAJIDA Foundation (SF) is presented. From September to November 2021, using document review, field observation and in-depth interviews, four aspects of their COVID-19 pandemic related activities was explored - a) why and how SF initiated their COVID response; b) what adaptations were made to their usual programmes; c) how SF's response to COVID-19 were designed and what were the anticipated challenges including overcoming measures; and d) perception of the staff about SF's activities related to COVID-19. Fifteen in-depth interviews were conducted with three groups of SF staff: frontliners, managers and leaders.\r\n\r\nThe impact of COVID-19 has been beyond health emergencies and posed multidimensional challenges. SF took a two-pronged approach - aid the government to respond to the emergency and adopt an all-inclusive plan to address diverse challenges related to overall well-being of the population. The underlying strategy of their response has been to: define the challenge of COVID-19 and identify required expertise and resources, ensure people's health and social wellbeing, adjust existing organisational processes, ensure functional partnership with other organisations for effective resource and task sharing, and safeguard health and wellbeing of the organisation's own employees.\r\n\r\nThe findings suggest a '4C framework' including four components as the basis of a comprehensive response to emergencies by NGOs: 1. Capability assessment to identify who are in need and what is needed; 2. Collaboration with stakeholders to pool resources and expertise; 3. Compassionate leadership to ensure health and social safety of the employees which ensures their dedication in managing the emergency; and 4. Communication for quick and effective decision making, decentralisation, monitoring and coordination. It is expected that this '4C framework' can help NGOs to embark on a comprehensive response to manage emergencies in resource constrained low- and middle-income countries.", "doi": "10.1186/s12913-023-09643-w", "pmid": "37340495", "labels": {"Category: Social Science & Humanities": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC10283326"}, {"db": "pii", "key": "10.1186/s12913-023-09643-w"}], "notes": [], "created": "2023-10-04T09:30:46.347Z", "modified": "2023-10-04T10:03:45.896Z"}, {"entity": "publication", "iuid": "68a74d771c8a49bf9f26e13b0dd56271", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68a74d771c8a49bf9f26e13b0dd56271.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68a74d771c8a49bf9f26e13b0dd56271"}}, "title": "Drug interventions for prevention of COVID-19 progression to severe disease in outpatients: a systematic review with meta-analyses and trial sequential analyses (The LIVING Project).", "authors": [{"family": "Petersen", "given": "Johanne Juul", "initials": "JJ", "orcid": "0000-0001-9837-1958", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37a5ab98e9c2454599584fc77f72efe1.json"}}, {"family": "J\u00f8rgensen", "given": "Caroline Kamp", "initials": "CK", "orcid": "0000-0002-7756-4694", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1b41bcfde8a482ab3c137ca4124baa3.json"}}, {"family": "Faltermeier", "given": "Pascal", "initials": "P"}, {"family": "Siddiqui", "given": "Faiza", "initials": "F", "orcid": "0000-0002-8358-6259", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/444713ae12884f5cb2f5909e82be8170.json"}}, {"family": "Feinberg", "given": "Joshua", "initials": "J", "orcid": "0000-0003-1975-9300", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76c4aae6c02047078131ddaf618684f5.json"}}, {"family": "Nielsen", "given": "Emil Eik", "initials": "EE"}, {"family": "Torp Kristensen", "given": "Andreas", "initials": "A", "orcid": "0000-0002-4570-236X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d7e7db4d0ce4167a4ea31c1da5df461.json"}}, {"family": "Juul", "given": "Sophie", "initials": "S", "orcid": "0000-0002-6171-2904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76a1c669d07f4d559ae43063bb008b68.json"}}, {"family": "Holgersson", "given": "Johan", "initials": "J"}, {"family": "Nielsen", "given": "Niklas", "initials": "N"}, {"family": "Bentzer", "given": "Peter", "initials": "P"}, {"family": "Thabane", "given": "Lehana", "initials": "L", "orcid": "0000-0003-0355-9734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/499ab3d178774eaa9f6a44345dbf6a7c.json"}}, {"family": "Kwasi Korang", "given": "Steven", "initials": "S"}, {"family": "Klingenberg", "given": "Sarah", "initials": "S"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Jakobsen", "given": "Janus C", "initials": "JC"}], "type": "journal article", "published": "2023-06-20", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "6", "pages": "e064498"}, "abstract": "To assess the effects of interventions authorised by the European Medicines Agency (EMA) or the US Food and Drug Administration (FDA) for prevention of COVID-19 progression to severe disease in outpatients.\r\n\r\nOutpatient treatment.\r\n\r\nParticipants with a diagnosis of COVID-19 and the associated SARS-CoV-2 virus irrespective of age, sex and comorbidities.\r\n\r\nDrug interventions authorised by EMA or FDA.\r\n\r\nPrimary outcomes were all-cause mortality and serious adverse events.\r\n\r\nWe included 17 clinical trials randomising 16 257 participants to 8 different interventions authorised by EMA or FDA. 15/17 of the included trials (88.2%) were assessed at high risk of bias. Only molnupiravir and ritonavir-boosted nirmatrelvir seemed to improve both our primary outcomes. Meta-analyses showed that molnupiravir reduced the risk of death (relative risk (RR) 0.11, 95% CI 0.02 to 0.64; p=0.0145, 2 trials; very low certainty of evidence) and serious adverse events (RR 0.63, 95% CI 0.47 to 0.84; p=0.0018, 5 trials; very low certainty of evidence). Fisher's exact test showed that ritonavir-boosted nirmatrelvir reduced the risk of death (p=0.0002, 1 trial; very low certainty of evidence) and serious adverse events (p<0.0001, 1 trial; very low certainty of evidence) in 1 trial including 2246 patients, while another trial including 1140 patients reported 0 deaths in both groups.\r\n\r\nThe certainty of the evidence was very low, but, from the results of this study, molnupiravir showed the most consistent benefit and ranked highest among the approved interventions for prevention of COVID-19 progression to severe disease in outpatients. The lack of certain evidence should be considered when treating patients with COVID-19 for prevention of disease progression.\r\n\r\nCRD42020178787.", "doi": "10.1136/bmjopen-2022-064498", "pmid": "37339844", "labels": {"Category: Health": null, "Funder: VR": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10314423"}, {"db": "pii", "key": "bmjopen-2022-064498"}], "notes": [], "created": "2023-10-04T09:30:26.060Z", "modified": "2023-10-04T09:54:58.635Z"}, {"entity": "publication", "iuid": "f6cb2deed35b47a0a02ae2df7677df9f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6cb2deed35b47a0a02ae2df7677df9f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6cb2deed35b47a0a02ae2df7677df9f"}}, "title": "Diagnostic Usefulness of Spiroergometry and Risk Factors of Long COVID in Patients with Normal Left Ventricular Ejection Fraction.", "authors": [{"family": "Gryglewska-Wawrzak", "given": "Katarzyna", "initials": "K", "orcid": "0000-0001-7902-3042", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4d37e0f556244848e36712615c66efa.json"}}, {"family": "Sakowicz", "given": "Agata", "initials": "A", "orcid": "0000-0002-5083-2046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2ce71c0e6664383a44c8cc4cb61fcf3.json"}}, {"family": "Banach", "given": "Maciej", "initials": "M", "orcid": "0000-0001-6690-6874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/904a6969b0e244adb21ded395af3ac1a.json"}}, {"family": "Byty\u00e7i", "given": "Ibadete", "initials": "I", "orcid": "0000-0002-8996-4257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba2f218876104573a8e529b1c2b6f671.json"}}, {"family": "Bielecka-Dabrowa", "given": "Agata", "initials": "A", "orcid": "0000-0001-6666-3999", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b7cdcb731104a908bca628cd8b338e6.json"}}], "type": "journal article", "published": "2023-06-20", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "12", "issue": "12", "pages": null}, "abstract": "The emergence of the Coronavirus Disease 2019 (COVID-19) pandemic has brought forth various clinical manifestations and long-term complications, including a condition known as long COVID. Long COVID refers to a persistent set of symptoms that continue beyond the acute phase of the disease. This study investigated the risk factors and the utility of spiroergometry parameters for diagnosing patients with long COVID symptoms. The 146 patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with normal left ventricular ejection fraction and without respiratory diseases were included and divided into two groups: the group demonstrating long COVID symptoms [n = 44] and the group without long COVID symptoms [n = 102]. The clinical examinations, laboratory test results, echocardiography, non-invasive body mass analysis, and spiroergometry were evaluated. ClinicalTrials.gov Identifier: NCT04828629. Patients with long COVID symptoms had significantly higher age [58 (vs.) 44 years; p < 0.0001], metabolic age [53 vs. 45 years; p = 0.02)], left atrial diameter (LA) [37 vs. 35 mm; p = 0.04], left ventricular mass index (LVMI) [83 vs. 74 g/m2, p = 0.04], left diastolic filling velocity (A) [69 vs. 64 cm/s, p = 0.01], the ratio of peak velocity of early diastolic transmitral flow to peak velocity of early diastolic mitral annular motion (E/E') [7.35 vs. 6.05; p = 0.01], and a lower ratio of early to late diastolic transmitral flow velocity (E/A) [1.05 vs. 1.31; p = 0.01] compared to the control group. In cardiopulmonary exercise testing (CPET), long COVID patients presented lower forced vital capacity (FVC) [3.6 vs. 4.3 L; p < 0.0001], maximal oxygen consumption measured during incremental exercise indexed per kilogram (VO2max) [21 vs. 23 mL/min/kg; p = 0.04], respiratory exchange ratio (RER) [1.0 vs. 1.1; p = 0.04], forced expiratory volume in one second (FEV1) [2.90 vs. 3.25 L; p = 0.04], and a higher ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC%) [106 vs. 100%; p = 0.0002]. The laboratory results pointed out that patients with long COVID symptoms also had a lower rate of red blood cells (RBC) [4.4 vs. 4.6 \u00d7 106/uL; p = 0.01]; a higher level of glucose [92 vs. 90 mg/dL; p = 0.03]; a lower glomerular filtration rate (GFR) estimate by Modification of Diet in Renal Disease (MDRD) [88 vs. 95; p = 0.03]; and a higher level of hypersensitive cardiac Troponin T (hs-cTnT) [6.1 vs. 3.9 pg/mL; p = 0.04]. On the multivariate model, only FEV1/FVC% (OR 6.27, 95% CI: 2.64-14.86; p < 0.001) independently predicted the long COVID symptoms. Using the ROC analysis, the FEV1/FVC% \u2265 103 was the most powerful predictor of spiroergometry parameters (0.67 sensitive, 0.71 specific, AUC of 0.73; p < 0.001) in predicting the symptoms of long COVID. Spiroergometry parameters are useful in diagnosing long COVID and differentiating it from cardiovascular disease.", "doi": "10.3390/jcm12124160", "pmid": "37373853", "labels": {"Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10299442"}, {"db": "pii", "key": "jcm12124160"}, {"db": "ClinicalTrials.gov", "key": "NCT04828629"}], "notes": [], "created": "2023-10-04T09:32:51.948Z", "modified": "2023-10-04T11:13:26.785Z"}, {"entity": "publication", "iuid": "c7021304f6614e1aa11f020c15d29276", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7021304f6614e1aa11f020c15d29276.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7021304f6614e1aa11f020c15d29276"}}, "title": "Artificial intelligence-driven prediction of COVID-19-related hospitalization and death: a systematic review.", "authors": [{"family": "Shakibfar", "given": "Saeed", "initials": "S"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Zhao", "given": "Jing", "initials": "J"}, {"family": "Nordeng", "given": "Hedvig Marie Egeland", "initials": "HME"}, {"family": "Sandve", "given": "Geir Kjetil Ferkingstad", "initials": "GKF"}, {"family": "Pavlovic", "given": "Milena", "initials": "M"}, {"family": "Hajiebrahimi", "given": "Mohammadhossein", "initials": "M"}, {"family": "Andersen", "given": "Morten", "initials": "M"}, {"family": "Sessa", "given": "Maurizio", "initials": "M"}], "type": "systematic review", "published": "2023-06-20", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "1183725"}, "abstract": "To perform a systematic review on the use of Artificial Intelligence (AI) techniques for predicting COVID-19 hospitalization and mortality using primary and secondary data sources.\r\n\r\nCohort, clinical trials, meta-analyses, and observational studies investigating COVID-19 hospitalization or mortality using artificial intelligence techniques were eligible. Articles without a full text available in the English language were excluded.\r\n\r\nArticles recorded in Ovid MEDLINE from 01/01/2019 to 22/08/2022 were screened.\r\n\r\nWe extracted information on data sources, AI models, and epidemiological aspects of retrieved studies.\r\n\r\nA bias assessment of AI models was done using PROBAST.\r\n\r\nPatients tested positive for COVID-19.\r\n\r\nWe included 39 studies related to AI-based prediction of hospitalization and death related to COVID-19. The articles were published in the period 2019-2022, and mostly used Random Forest as the model with the best performance. AI models were trained using cohorts of individuals sampled from populations of European and non-European countries, mostly with cohort sample size <5,000. Data collection generally included information on demographics, clinical records, laboratory results, and pharmacological treatments (i.e., high-dimensional datasets). In most studies, the models were internally validated with cross-validation, but the majority of studies lacked external validation and calibration. Covariates were not prioritized using ensemble approaches in most of the studies, however, models still showed moderately good performances with Area under the Receiver operating characteristic Curve (AUC) values >0.7. According to the assessment with PROBAST, all models had a high risk of bias and/or concern regarding applicability.\r\n\r\nA broad range of AI techniques have been used to predict COVID-19 hospitalization and mortality. The studies reported good prediction performance of AI models, however, high risk of bias and/or concern regarding applicability were detected.", "doi": "10.3389/fpubh.2023.1183725", "pmid": "37408750", "labels": {"Funder: Forte": null, "Category: Public Health": null, "Category: Other": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: KAW/SciLifeLab": null, "Type: Review": null, "Funder: NordForsk": null}, "xrefs": [{"db": "pmc", "key": "PMC10319067"}], "notes": [], "created": "2023-10-04T12:09:35.195Z", "modified": "2023-10-04T12:57:56.322Z"}, {"entity": "publication", "iuid": "5ab564d97000495aac9c28ce671845c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5ab564d97000495aac9c28ce671845c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5ab564d97000495aac9c28ce671845c9"}}, "title": "Experiences of aftermath of COVID-19 in relation to social, financial and health related aspects among previously hospitalized patients: a qualitative exploration.", "authors": [{"family": "Nandonik", "given": "Ahmed Jojan", "initials": "AJ"}, {"family": "Das Pooja", "given": "Shangjucta", "initials": "S"}, {"family": "Ahmed", "given": "Tanvir", "initials": "T"}, {"family": "Parvez", "given": "Anwar", "initials": "A"}, {"family": "Kabir", "given": "Zarina Nahar", "initials": "ZN"}], "type": "journal article", "published": "2023-06-15", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "1196810"}, "abstract": "There is increasing evidence of long-term consequences of COVID-19. The world has seen multidimensional impact of the pandemic and Bangladesh is no exception to that. Policymakers in Bangladesh laid out strategies to curb the initial spread of COVID-19. However, long-term consequences of COVID-19 received little or no attention in the country. Evidence suggests that people presumed to be recovered face multidimensional post-covid consequences. This study aimed to describe the aftermath of COVID-19 in relation to social, financial and health related aspects among previously hospitalized patients.\r\n\r\nThis descriptive qualitative study includes participants (n = 14) who were previously hospitalized for COVID-19 and returned home after recovery. The participants were part of a mixed method study from which they were purposively selected. Semi-structured in-depth interviews were conducted over telephone. Inductive content analysis was used to analyze the data.\r\n\r\nTwelve sub-categories emerged from the data analysis which converged into five main categories. The main categories included perspective on physical health, financial struggle, life adjustment, interplay between different domains, and spontaneous support.\r\n\r\nThe lived experiences of COVID-19 recovered patients highlighted multidimensional impact on their daily lives. Physical and psychological wellbeing found to be related to the effort of restoring financial status. People's perception about life altered due to pandemic, for few the pandemic was an opportunity to grow while others found it difficult to accept the hardship. Such multidimensional post COVID-19 impact on people's lives and wellbeing holds considerable implication for response and mitigation plan for future related pandemics.", "doi": "10.3389/fpubh.2023.1196810", "pmid": "37397755", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10311015"}], "notes": [], "created": "2023-10-04T12:08:58.334Z", "modified": "2023-10-04T12:45:46.487Z"}, {"entity": "publication", "iuid": "d881e0269eb546b5b9f6e7afe681a3ea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d881e0269eb546b5b9f6e7afe681a3ea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d881e0269eb546b5b9f6e7afe681a3ea"}}, "title": "Effects of the COVID-19 pandemic on mental health, working, and life situation of employees in the Swedish hospitality industry.", "authors": [{"family": "Feltmann", "given": "Kristin", "initials": "K"}, {"family": "Gustafsson", "given": "Nina-Katri J", "initials": "NJ"}, {"family": "Elg\u00e1n", "given": "Tobias H", "initials": "TH"}, {"family": "Gripenberg", "given": "Johanna", "initials": "J"}, {"family": "Kvillemo", "given": "Pia", "initials": "P"}], "type": "journal article", "published": "2023-06-14", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "1178847"}, "abstract": "Previous studies reported that the coronavirus disease (COVID-19) pandemic has negatively affected the mental health of employees in the hospitality industry internationally, however, its effect in Sweden has not been studied. Unlike several other countries, Sweden never enforced a lockdown. Restaurants, bars, and hotels could remain open and host a limited number of guests but had to abide by certain restrictions.\r\n\r\nA cross-sectional survey was distributed among hospitality industry employees containing questions regarding the perceived effects of the pandemic on the respondents' working and life situations and their physical and psychological health. The sample consisted of 699 individuals, with a response rate of 47.9%.\r\n\r\nAlthough several respondents had been laid off or furloughed, the majority of the sample remained at the same employer. However, more than half of the respondents reported that their economic situation had deteriorated. Compared to before the pandemic, 38.1% experienced elevated levels of stress, 48.3% experienced elevated levels of worry, and 31.4% reported worsened mood. A deteriorating personal economy and difficulty in following COVID-19-related restrictions at work were associated with the worsening of these three mental health aspects. While the fear of becoming infected with COVID-19 was related to higher levels of stress, the fear of infecting others was related to higher levels of worry.\r\n\r\nAlthough Sweden imposed less strict measures than most other countries, the personal economy and mental health of hospitality workers were negatively affected by the COVID-19 pandemic.", "doi": "10.3389/fpubh.2023.1178847", "pmid": "37388155", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10303113"}], "notes": [], "created": "2023-10-04T09:31:14.241Z", "modified": "2023-10-04T10:46:13.914Z"}, {"entity": "publication", "iuid": "35e61dc5b20249189443661e0e8d32db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/35e61dc5b20249189443661e0e8d32db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/35e61dc5b20249189443661e0e8d32db"}}, "title": "Disrupting the opportunity narrative: navigating transformation in times of uncertainty and crisis.", "authors": [{"family": "Moore", "given": "Michele-Lee", "initials": "M"}, {"family": "Hermanus", "given": "Lauren", "initials": "L"}, {"family": "Drimie", "given": "Scott", "initials": "S"}, {"family": "Rose", "given": "Loretta", "initials": "L"}, {"family": "Mbaligontsi", "given": "Mandisa", "initials": "M"}, {"family": "Musarurwa", "given": "Hillary", "initials": "H"}, {"family": "Ogutu", "given": "Moses", "initials": "M"}, {"family": "Oyowe", "given": "Khanyisa", "initials": "K"}, {"family": "Olsson", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2023-06-14", "journal": {"title": "Sustain Sci", "issn": "1862-4057", "issn-l": null, "volume": null, "issue": null, "pages": "1-17"}, "abstract": "COVID-19 posed threats for health and well-being directly, but it also revealed and exacerbated social-ecological inequalities, worsening hunger and poverty for millions. For those focused on transforming complex and problematic system dynamics, the question was whether such devastation could create a formative moment in which transformative change could become possible. Our study examines the experiences of change agents in six African countries engaged in efforts to create or support transformative change processes. To better understand the relationship between crisis, agency, and transformation, we explored how they navigated their changed conditions and the responses to COVID-19. We document three impacts: economic impacts, hunger, and gender-based violence and we examine how they (re)shaped the opportunity contexts for change. Finally, we identify four kinds of uncertainties that emerged as a result of policy responses, including uncertainty about the: (1) robustness of preparing a system to sustain a transformative trajectory, (2) sequencing and scaling of changes within and across systems, (3) hesitancy and exhaustion effects, and (4) long-term effects of surveillance, and we describe the associated change agent strategies. We suggest these uncertainties represent new theoretical ground for future transformations research.\r\n\r\nThe online version contains supplementary material available at 10.1007/s11625-023-01340-1.", "doi": "10.1007/s11625-023-01340-1", "pmid": "37363311", "labels": {"Category: Social Science & Humanities": null, "Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10265562"}, {"db": "pii", "key": "1340"}], "notes": [], "created": "2023-10-04T09:32:21.466Z", "modified": "2023-10-04T11:05:44.341Z"}, {"entity": "publication", "iuid": "6bfd31e9905e445fac42bbb935e9d426", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6bfd31e9905e445fac42bbb935e9d426.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6bfd31e9905e445fac42bbb935e9d426"}}, "title": "Behavioral responses of terrestrial mammals to COVID-19 lockdowns.", "authors": [{"family": "Tucker", "given": "Marlee A", "initials": "MA", "orcid": "0000-0001-7535-3431", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39e654d94797463893f3590bb779d056.json"}}, {"family": "Schipper", "given": "Aafke M", "initials": "AM", "orcid": "0000-0002-5667-0893", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68a75c2ed9924c70897ac6947592c335.json"}}, {"family": "Adams", "given": "Tempe S F", "initials": "TSF"}, {"family": "Attias", "given": "Nina", "initials": "N", "orcid": "0000-0002-9472-6763", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f703ab61b3364654b989cbcc3ed99ce2.json"}}, {"family": "Avgar", "given": "Tal", "initials": "T", "orcid": "0000-0002-8764-6976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8428fb8febb44f49f6cd4abbe4bd61f.json"}}, {"family": "Babic", "given": "Natarsha L", "initials": "NL", "orcid": "0000-0001-6813-9728", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c49b0167d18344f9802d241103a8fa72.json"}}, {"family": "Barker", "given": "Kristin J", "initials": "KJ", "orcid": "0000-0002-1618-7610", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bea5c2a78de34997ab5af9c72359b8ef.json"}}, {"family": "Bastille-Rousseau", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-6799-639X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f1001971c674ae79e6a0b72d5842310.json"}}, {"family": "Behr", "given": "Dominik M", "initials": "DM", "orcid": "0000-0001-7378-8538", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b035004e8f4048c581b6fe5df098c93f.json"}}, {"family": "Belant", "given": "Jerrold L", "initials": "JL"}, {"family": "Beyer", "given": "Dean E", "initials": "DE"}, {"family": "Blaum", "given": "Niels", "initials": "N", "orcid": "0000-0001-6807-5162", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3550ab0cc47b489bb0dddcac51db8563.json"}}, {"family": "Blount", "given": "J David", "initials": "JD", "orcid": "0000-0003-3208-2947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b6367bd4df5545a5ba9ed2a6a53b8ae9.json"}}, {"family": "Bockm\u00fchl", "given": "Dirk", "initials": "D"}, {"family": "Pires Boulhosa", "given": "Ricardo Luiz", "initials": "RL", "orcid": "0000-0002-1212-7805", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c6aaa32848b482ab3e9b18bfda7900b.json"}}, {"family": "Brown", "given": "Michael B", "initials": "MB", "orcid": "0000-0002-0119-0614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a0d7860afa14b10a1a1862aa39c3cfa.json"}}, {"family": "Buuveibaatar", "given": "Bayarbaatar", "initials": "B", "orcid": "0000-0003-0404-269X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd145213190b4541b84fd34417aba1bc.json"}}, {"family": "Cagnacci", "given": "Francesca", "initials": "F", "orcid": "0000-0002-4954-9980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d05696a8933422b8b9b1cde6acb9ac4.json"}}, {"family": "Calabrese", "given": "Justin M", "initials": "JM", "orcid": "0000-0003-0575-6408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67d44f10243745e680172193412492e6.json"}}, {"family": "\u010cerne", "given": "Rok", "initials": "R"}, {"family": "Chamaill\u00e9-Jammes", "given": "Simon", "initials": "S", "orcid": "0000-0003-0505-6620", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4b1216168fc4acd89859a2f7f684faf.json"}}, {"family": "Chan", "given": "Aung Nyein", "initials": "AN", "orcid": "0000-0003-2706-6969", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc84aeda43b540ca84aa81780998ede3.json"}}, {"family": "Chase", "given": "Michael J", "initials": "MJ"}, {"family": "Chaval", "given": "Yannick", "initials": "Y"}, {"family": "Chenaux-Ibrahim", "given": "Yvette", "initials": "Y", "orcid": "0000-0002-7239-9108", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d264598b4f04e77ba0f6c4c98c9e296.json"}}, {"family": "Cherry", "given": "Seth G", "initials": "SG", "orcid": "0000-0003-4242-3629", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6338b3468954b26a4bb6426e6f34346.json"}}, {"family": "\u0106irovi\u0107", "given": "Du\u0161ko", "initials": "D", "orcid": "0000-0001-9468-0948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0997b4f72b3a4cf9b7aa79f20fc2b94e.json"}}, {"family": "\u00c7oban", "given": "Emrah", "initials": "E", "orcid": "0000-0002-9020-2014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1bdeb742f2c48d689e7a13db719b348.json"}}, {"family": "Cole", "given": "Eric K", "initials": "EK", "orcid": "0000-0002-2229-5853", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56e3c4fab7a24dc282847a7010660ca5.json"}}, {"family": "Conlee", "given": "Laura", "initials": "L"}, {"family": "Courtemanch", "given": "Alyson", "initials": "A", "orcid": "0000-0001-7405-7657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b93b87aca8a4b07bfce2915c7afaca4.json"}}, {"family": "Cozzi", "given": "Gabriele", "initials": "G", "orcid": "0000-0002-1744-1940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/468af7bfd1d84ecf9f093421b6e17125.json"}}, {"family": "Davidson", "given": "Sarah C", "initials": "SC", "orcid": "0000-0002-2766-9201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4104be953f3d4f82829883993dc311ae.json"}}, {"family": "DeBloois", "given": "Darren", "initials": "D", "orcid": "0000-0002-5960-0524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/029508ab21c440c9b8623be18da70807.json"}}, {"family": "Dejid", "given": "Nandintsetseg", "initials": "N", "orcid": "0000-0002-5376-3808", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d78e716ee1849c8bac3885e9ddb70a1.json"}}, {"family": "DeNicola", "given": "Vickie", "initials": "V", "orcid": "0000-0003-3558-2541", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa24a0c2330f4f70859ecc45a8898e49.json"}}, {"family": "Desbiez", "given": "Arnaud L J", "initials": "ALJ", "orcid": "0000-0001-5968-6025", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f83ef1c96e74a208e032b68ee33e5cd.json"}}, {"family": "Douglas-Hamilton", "given": "Iain", "initials": "I", "orcid": "0000-0002-7942-7554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c5c3b38ed2c4109887974d48265babc.json"}}, {"family": "Drake", "given": "David", "initials": "D"}, {"family": "Egan", "given": "Michael", "initials": "M"}, {"family": "Eikelboom", "given": "Jasper A J", "initials": "JAJ", "orcid": "0000-0002-5107-4427", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/783112dcb8fa440a8a7f1dc395436670.json"}}, {"family": "Fagan", "given": "William F", "initials": "WF", "orcid": "0000-0003-2433-9052", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9c9b1c4511b42829a6bdc819f83d2b6.json"}}, {"family": "Farmer", "given": "Morgan J", "initials": "MJ", "orcid": "0000-0002-6320-9587", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7762aff3c005490e9817f6d31f8cc708.json"}}, {"family": "Fennessy", "given": "Julian", "initials": "J", "orcid": "0000-0001-5871-8267", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28050549c3f04a328cba87965d802b01.json"}}, {"family": "Finnegan", "given": "Shannon P", "initials": "SP", "orcid": "0000-0003-3265-9996", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/138a7e1b278441eb84bc1ce3bc0821e3.json"}}, {"family": "Fleming", "given": "Christen H", "initials": "CH", "orcid": "0000-0002-9356-6518", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9119e001684465aaab71a752ab721fb.json"}}, {"family": "Fournier", "given": "Bonnie", "initials": "B"}, {"family": "Fowler", "given": "Nicholas L", "initials": "NL", "orcid": "0000-0003-3977-0945", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b18a5ccfac24095ad4df1d65fd8b7bb.json"}}, {"family": "Gantchoff", "given": "Mariela G", "initials": "MG", "orcid": "0000-0002-7098-8072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42810228f6c4465f93b8775e3592a31c.json"}}, {"family": "Garnier", "given": "Alexandre", "initials": "A", "orcid": "0000-0003-3515-8556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc98ff203d0e490394a489f2e31f238b.json"}}, {"family": "Gehr", "given": "Benedikt", "initials": "B", "orcid": "0000-0002-1044-9296", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42fea1cd196a4c72a3e3e78b12e06054.json"}}, {"family": "Geremia", "given": "Chris", "initials": "C"}, {"family": "Goheen", "given": "Jacob R", "initials": "JR", "orcid": "0000-0001-6609-0692", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e21fbd5ccba45ee92e12d568b3ff7fb.json"}}, {"family": "Hauptfleisch", "given": "Morgan L", "initials": "ML", "orcid": "0000-0003-0654-0887", "researcher": {"href": 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"Stewart", "given": "Cheyenne", "initials": "C", "orcid": "0000-0003-3394-1926", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44af4cd029dd44a5b962ef5f0532a610.json"}}, {"family": "Strand", "given": "Olav", "initials": "O"}, {"family": "Sunde", "given": "Peter", "initials": "P", "orcid": "0000-0002-7485-037X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6aeaa45baa1c49be961015b46e902313.json"}}, {"family": "Svoboda", "given": "Nathan J", "initials": "NJ", "orcid": "0000-0002-1939-0569", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81a560acb4194666bd618a4d4d73447a.json"}}, {"family": "Swart", "given": "Jonathan", "initials": "J"}, {"family": "Thompson", "given": "Jeffrey J", "initials": "JJ", "orcid": "0000-0002-5632-1466", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a51bc818b4874660ba0ef67ab54e0312.json"}}, {"family": "Toal", "given": "Katrina L", "initials": "KL"}, {"family": "Uiseb", "given": "Kenneth", "initials": "K", "orcid": "0000-0002-5284-9917", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/16d9082540ad420390d2d9ffd6387c14.json"}}, {"family": "VanAcker", "given": "Meredith C", "initials": "MC", "orcid": "0000-0002-5690-9139", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80932eb728274c65aad725e335addd82.json"}}, {"family": "Velilla", "given": "Marianela", "initials": "M", "orcid": "0000-0002-4212-885X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73a5e56198c746428c55e6eb008ba0a7.json"}}, {"family": "Verzuh", "given": "Tana L", "initials": "TL", "orcid": "0000-0003-4027-5415", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2758992cbdfb413cbd74a836ed38c0bc.json"}}, {"family": "Wachter", "given": "Bettina", "initials": "B", "orcid": "0000-0002-0414-2298", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa93e479797847b7aa92596fa42abca3.json"}}, {"family": "Wagler", "given": "Brittany L", "initials": "BL", "orcid": "0000-0001-9526-820X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b18fb21a5f64401da1c860eac6b18e7e.json"}}, {"family": "Whittington", "given": "Jesse", "initials": "J", "orcid": "0000-0002-4129-7491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1fd61d870e474140acfa1a4c94f7d6a6.json"}}, {"family": "Wikelski", "given": "Martin", "initials": "M", "orcid": "0000-0002-9790-7025", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c024723549c485886b238320b8d2df5.json"}}, {"family": "Wilmers", "given": "Christopher C", "initials": "CC", "orcid": "0000-0003-2063-1478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7bbb1a449b9c47c1ba23cbe52421f41d.json"}}, {"family": "Wittemyer", "given": "George", "initials": "G", "orcid": "0000-0003-1640-5355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a34151a7cae947678b526d0729dfb35b.json"}}, {"family": "Young", "given": "Julie K", "initials": "JK", "orcid": "0000-0003-4522-0157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/978312c400d244298994c1ff848de78b.json"}}, {"family": "Zi\u0119ba", "given": "Filip", "initials": "F"}, {"family": "Zwijacz-Kozica", "given": "Tomasz", "initials": "T", "orcid": "0000-0002-7488-975X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a7eb67e79544a04b42db4c701fb9966.json"}}, {"family": "Huijbregts", "given": "Mark A J", "initials": "MAJ", "orcid": "0000-0002-7037-680X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/292dab5a2730421f806d017d8c048708.json"}}, {"family": "Mueller", "given": "Thomas", "initials": "T", "orcid": "0000-0001-9305-7716", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a8409fac8db41ca8b1ae9b4bd129a8a.json"}}], "type": "journal article", "published": "2023-06-09", "journal": {"title": "Science", "issn": "1095-9203", "issn-l": "0036-8075", "volume": "380", "issue": "6649", "pages": "1059-1064"}, "abstract": "COVID-19 lockdowns in early 2020 reduced human mobility, providing an opportunity to disentangle its effects on animals from those of landscape modifications. Using GPS data, we compared movements and road avoidance of 2300 terrestrial mammals (43 species) during the lockdowns to the same period in 2019. Individual responses were variable with no change in average movements or road avoidance behavior, likely due to variable lockdown conditions. However, under strict lockdowns 10-day 95th percentile displacements increased by 73%, suggesting increased landscape permeability. Animals' 1-hour 95th percentile displacements declined by 12% and animals were 36% closer to roads in areas of high human footprint, indicating reduced avoidance during lockdowns. Overall, lockdowns rapidly altered some spatial behaviors, highlighting variable but substantial impacts of human mobility on wildlife worldwide.", "doi": "10.1126/science.abo6499", "pmid": "37289888", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:32:57.916Z", "modified": "2023-10-04T11:15:23.800Z"}, {"entity": "publication", "iuid": "2e7edc9ebbdc404690076ca003d8d320", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e7edc9ebbdc404690076ca003d8d320.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e7edc9ebbdc404690076ca003d8d320"}}, "title": "Challenges in preserving the \"good doctor\" norm: physicians' discourses on changes to the medical logic during the initial wave of the COVID-19 pandemic.", "authors": [{"family": "H\u00e4rgestam", "given": "Maria", "initials": "M"}, {"family": "Jacobsson", "given": "Maritha", "initials": "M"}, {"family": "B\u00e5\u00e5the", "given": "Fredrik", "initials": "F"}, {"family": "Brulin", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2023-06-08", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "14", "issue": null, "pages": "1083047"}, "abstract": "The COVID-19 pandemic was a tremendous challenge to the practice of modern medicine. In this study, we use neo-institutional theory to gain an in-depth understanding of how physicians in Sweden narrate how they position themselves as physicians when practicing modern medicine during the first wave of the pandemic. At focus is medical logic, which integrates rules and routines based on medical evidence, practical experience, and patient perspectives in clinical decision-making.\r\n\r\nTo understand how physicians construct their versions of the pandemic and how it impacted the medical logic in which they practice, we analyzed the interviews from 28 physicians in Sweden by discursive psychology.\r\n\r\nThe interpretative repertoires showed how COVID-19 created an experience of knowledge vacuum in medical logic and how physicians dealt with clinical patient dilemmas. They had to find unorthodox ways to rebuild a sense of medical evidence while still being responsible for clinical decision-making for patients with critical care needs.\r\n\r\nIn the knowledge vacuum occurring during the first wave of COVID-19, physicians could not use their common medical knowledge nor rely on published evidence or their clinical judgment. They were thus challenged in their norm of being the \"good doctor\". One practical implication of this research is that it provides a rich empirical account where physicians are allowed to mirror, make sense, and normalize their own individual and sometimes painful struggle to uphold the professional role and related medical responsibility in the early phases of the COVID-19 pandemic. It will be important to follow how the tremendous challenge of COVID-19 to medical logic plays out over time in the community of physicians. There are many dimensions to study, with sick leave, burnout, and attrition being some interesting areas.", "doi": "10.3389/fpsyg.2023.1083047", "pmid": "37359864", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Funder: Forte": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10285475"}], "notes": [], "created": "2023-10-04T09:31:01.174Z", "modified": "2023-10-04T10:40:57.789Z"}, {"entity": "publication", "iuid": "197891042362460798eb43322d0e99aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/197891042362460798eb43322d0e99aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/197891042362460798eb43322d0e99aa"}}, "title": "The increasing age of respiratory syncytial virus-related hospitalisation during COVID-19 pandemic in Lyon was associated with reduced hospitalisation costs.", "authors": [{"family": "Roy", "given": "\u00c1lvaro", "initials": "\u00c1"}, {"family": "Polazzi", "given": "St\u00e9phanie", "initials": "S"}, {"family": "Ploin", "given": "Dominique", "initials": "D"}, {"family": "Gillet", "given": "Yves", "initials": "Y"}, {"family": "Javouhey", "given": "Etienne", "initials": "E"}, {"family": "Lina", "given": "Bruno", "initials": "B"}, {"family": "VRS study group in Lyon", "given": "", "initials": ""}, {"family": "Myard-Dury", "given": "Anne-Florence", "initials": "A"}, {"family": "Couray-Targe", "given": "Sandrine", "initials": "S"}, {"family": "Duclos", "given": "Antoine", "initials": "A"}, {"family": "Casalegno", "given": "Jean-S\u00e9bastien", "initials": "J"}], "type": "journal article", "published": "2023-06-07", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null, "volume": "41", "issue": "25", "pages": "3796-3800"}, "abstract": "Preventive measures applied during the COVID-19 pandemic have modified the age distribution, the clinical severity and the incidence of Respiratory Syncytial Virus (RSV) hospitalisations during the 2020/21 RSV season. The aim of the present study was to estimate the impact of these aspects on RSV-associated hospitalisations (RSVH) costs stratified by age group between pre-COVID-19 seasons and 2020/21 RSV season.\r\n\r\nWe compared the incidence, the median costs, and total RSVH costs from the national health insurance perspective in children < 24 months of age during the COVID-19 period (2020/21 RSV season) with a pre-COVID-19 period (2014/17 RSV seasons). Children were born and hospitalised in the Lyon metropolitan area. RSVH costs were extracted from the French medical information system (Programme de M\u00e9dicalisation des Syst\u00e9mes d'Information).\r\n\r\nThe RSVH-incidence rate per 1000 infants aged < 3 months decreased significantly from 4.6 (95 % CI [4.1; 5.2]) to 3.1 (95 % CI [2.4; 4.0]), and increased in older infants and children up to 24 months of age during the 2020/21 RSV season. Overall, RSVH costs for RSVH cases aged below 2 years old decreased by \u20ac201,770 (31 %) during 2020/21 RSV season compared to the mean pre-COVID-19 costs.\r\n\r\nThe sharp reduction in costs of RSVH in infants aged < 3 months outweighed the modest increase in costs observed in the 3-24 months age group. Therefore, conferring a temporal protection through passive immunisation to infants aged < 3 months should have a major impact on RSVH costs even if it results in an increase of RSVH in older children infected later in life. Nevertheless, stakeholders should be aware of this potential increase of RSVH in older age groups presenting with a wider range of disease to avoid any bias in estimating the cost-effectiveness of passive immunisation strategies.", "doi": "10.1016/j.vaccine.2023.05.021", "pmid": "37198017", "labels": {"Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10169568"}, {"db": "pii", "key": "S0264-410X(23)00548-0"}], "notes": [], "created": "2023-10-04T05:11:05.684Z", "modified": "2023-10-04T07:06:48.858Z"}, {"entity": "publication", "iuid": "71bc203ffa044fe28ec637a7c3070875", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/71bc203ffa044fe28ec637a7c3070875.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/71bc203ffa044fe28ec637a7c3070875"}}, "title": "Hindering and enabling factors for young employees with common mental disorder to remain at or return to work affected by the Covid-19 pandemic - a qualitative interview study with young employees and managers.", "authors": [{"family": "Wallberg", "given": "Martina", "initials": "M", "orcid": "0000-0002-8881-1822", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9349fb21e752467c85bd602c36510a91.json"}}, {"family": "Tinnerholm Ljungberg", "given": "Helena", "initials": "H"}, {"family": "Bj\u00f6rk Br\u00e4mberg", "given": "Elisabeth", "initials": "E"}, {"family": "Nybergh", "given": "Lotta", "initials": "L"}, {"family": "Jensen", "given": "Irene", "initials": "I"}, {"family": "Olsson", "given": "Caroline", "initials": "C", "orcid": "0000-0001-7561-2480", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/38563e81bb7d4ec794d7798fed320161.json"}}], "type": "journal article", "published": "2023-06-07", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "6", "pages": "e0286819"}, "abstract": "During the COVID-19 pandemic, changes in working life occurred, even in Sweden, where there was no general lockdown. The aim of this study was to examine how the COVID-19 pandemic was perceived as affecting the hindering and enabling factors among young employees with CMD to remain at or return to work, here as investigated from the perspective of young employees and managers.\r\n\r\nA qualitative design was applied with semistructured interviews with 23 managers and 25 young employees (20-29 years old). The interviews were recorded and transcribed verbatim, and the parts of the interviews related to the aim of this article were analysed using conventional content analysis.\r\n\r\nThe hindering factors were changed working conditions, decreased well-being when spending more time at home, and uncertainty. The enabling factors were decreased demands, increased balance, and well-functioning work processes. For managers it is important to be aware of warning signals indicating blurred boundaries between work and private life, to create and maintain well-functioning communication, and leave room for recovery.\r\n\r\nThe hindering and enabling factors can be described as two sides of the same coin. Changes in the working conditions during the pandemic led to difficulties for both young employees and managers when the margins of maneuver were insufficient.", "doi": "10.1371/journal.pone.0286819", "pmid": "37285347", "labels": {"Category: Social Science & Humanities": null, "Funder: Forte": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10246792"}, {"db": "pii", "key": "PONE-D-22-17806"}], "notes": [], "created": "2023-10-04T09:31:53.412Z", "modified": "2023-10-04T10:57:11.810Z"}, {"entity": "publication", "iuid": "34746c67d2384baa9e428ac6d9b6ad2c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/34746c67d2384baa9e428ac6d9b6ad2c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/34746c67d2384baa9e428ac6d9b6ad2c"}}, "title": "COVID-19 hospitalization outcomes in adults by HIV status; a nation-wide register-based study.", "authors": [{"family": "M\u00f6ller", "given": "Isabela Killander", "initials": "IK", "orcid": "0000-0002-4105-2902", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3278886cd2af47229149a55443b38f09.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Wagner", "given": "Philippe", "initials": "P"}, {"family": "Spar\u00e9n", "given": "P\u00e4r", "initials": "P"}, {"family": "Carlander", "given": "Christina", "initials": "C", "orcid": "0000-0001-9962-5964", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b819f761acf34fdea8f11d0743a5b86c.json"}}], "type": "journal article", "published": "2023-06-07", "journal": {"title": "HIV Med", "issn": "1468-1293", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To assess the outcome of patients hospitalized with COVID-19 by HIV status and risk factors for severe COVID-19 in people living with HIV (PWH), we performed a nationwide cohort study using register data.\r\n\r\nAll people aged \u226518 years hospitalized with a primary COVID-19 diagnosis (U07.1 or U07.2) in Sweden between February 2020 and October 2021 were included. The primary outcome was severe COVID-19 [intensive care unit (ICU) admission or 90-day mortality]. Secondary outcomes were days in hospital and ICU, complications in hospital, and risk factors for severe COVID-19 in PWH. Regression analyses were performed to assess severe COVID-19 by HIV status and risk factors.\r\n\r\nData from 64 815 hospitalized patients were collected, of whom 121 were PWH (0.18%). PWH were younger (p < 0.001), and larger proportions were men (p = 0.014) and migrants (p < 0.001). Almost all PWH had undetectable HIV-RNA (93%) and high CD4 T-cell counts (median = 560 cells/\u03bcL, interquartile range: 376-780). In an unadjusted model, PWH had statistically significant lower odds of severe COVID-19 compared with patients without HIV [odds ratio (OR) = 0.6, 95% confidence interval (CI): 0.34-0.94], but there was no significant difference after adjusting for age and comorbidity (adjusted OR = 0.7, 95% CI: 0.43-1.26). A statistically significant lower proportion of PWH (8%, 95% CI: 5-15%) died within 90 days compared with those without HIV (16%, 95% CI: 15-16%, p = 0.024). There was no statistically significant difference in days in hospital and complications during the hospital stay between PWH and patients without HIV.\r\n\r\nIn this nationwide study including well-treated PWH, HIV was not a risk factor in hospitalized patients for developing severe COVID-19.", "doi": "10.1111/hiv.13515", "pmid": "37286199", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:30:33.798Z", "modified": "2023-10-04T09:58:23.498Z"}, {"entity": "publication", "iuid": "f12410c233584d12a1290f24ac6cac03", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f12410c233584d12a1290f24ac6cac03.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f12410c233584d12a1290f24ac6cac03"}}, "title": "Functional Foods: A Promising Strategy for Restoring Gut Microbiota Diversity Impacted by SARS-CoV-2 Variants.", "authors": [{"family": "Banerjee", "given": "Antara", "initials": "A"}, {"family": "Somasundaram", "given": "Indumathi", "initials": "I"}, {"family": "Das", "given": "Diptimayee", "initials": "D"}, {"family": "Jain Manoj", "given": "Samatha", "initials": "S"}, {"family": "Banu", "given": "Husaina", "initials": "H"}, {"family": "Mitta Suresh", "given": "Pavane", "initials": "P"}, {"family": "Paul", "given": "Sujay", "initials": "S", "orcid": "0000-0001-5024-7261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1c15a587da6470ea73c6e3c29a4ba6b.json"}}, {"family": "Bisgin", "given": "Atil", "initials": "A", "orcid": "0000-0002-2053-9076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13bfbc623c634b269c7c69fbb303254d.json"}}, {"family": "Zhang", "given": "Hong", "initials": "H", "orcid": "0000-0003-1834-1578", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/85be136845f6469c946e000f38f18f28.json"}}, {"family": "Sun", "given": "Xiao-Feng", "initials": "X"}, {"family": "Duttaroy", "given": "Asim K", "initials": "AK", "orcid": "0000-0003-1619-3778", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/464702978fa64a368987901580720fe8.json"}}, {"family": "Pathak", "given": "Surajit", "initials": "S", "orcid": "0000-0002-7306-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2cfa7af2c5c549cc82d6f407b1e1e56b.json"}}], "type": "journal article", "published": "2023-06-05", "journal": {"title": "Nutrients", "issn": "2072-6643", "issn-l": null, "volume": "15", "issue": "11", "pages": null}, "abstract": "Natural herbs and functional foods contain bioactive molecules capable of augmenting the immune system and mediating anti-viral functions. Functional foods, such as prebiotics, probiotics, and dietary fibers, have been shown to have positive effects on gut microbiota diversity and immune function. The use of functional foods has been linked to enhanced immunity, regeneration, improved cognitive function, maintenance of gut microbiota, and significant improvement in overall health. The gut microbiota plays a critical role in maintaining overall health and immune function, and disruptions to its balance have been linked to various health problems. SARS-CoV-2 infection has been shown to affect gut microbiota diversity, and the emergence of variants poses new challenges to combat the virus. SARS-CoV-2 recognizes and infects human cells through ACE2 receptors prevalent in lung and gut epithelial cells. Humans are prone to SARS-CoV-2 infection because their respiratory and gastrointestinal tracts are rich in microbial diversity and contain high levels of ACE2 and TMPRSS2. This review article explores the potential use of functional foods in mitigating the impact of SARS-CoV-2 variants on gut microbiota diversity, and the potential use of functional foods as a strategy to combat these effects.", "doi": "10.3390/nu15112631", "pmid": "37299594", "labels": {"Category: Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC10255361"}, {"db": "pii", "key": "nu15112631"}], "notes": [], "created": "2023-10-04T09:32:23.905Z", "modified": "2023-10-04T11:06:54.692Z"}, {"entity": "publication", "iuid": "e0284c17d08b406b99333dcc60d91f37", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e0284c17d08b406b99333dcc60d91f37.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e0284c17d08b406b99333dcc60d91f37"}}, "title": "Coronavirus disease 2019 and gastrointestinal disorders in children.", "authors": [{"family": "R\u00f6ckert Tjernberg", "given": "Anna", "initials": "A", "orcid": "0000-0001-8126-9738", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14df79dd609a4ec1baa8dfda5d7826c7.json"}}, {"family": "Malmborg", "given": "Petter", "initials": "P"}, {"family": "M\u00e5rild", "given": "Karl", "initials": "K"}], "type": "journal article", "published": "2023-06-05", "journal": {"title": "Therap Adv Gastroenterol", "issn": "1756-283X", "issn-l": null, "volume": "16", "issue": null, "pages": "17562848231177612"}, "abstract": "During the past 3 years, the coronavirus disease 2019 (COVID-19) pandemic has had a great impact on people all over the world. However, it has become evident that disease manifestations and severity differ across age groups. Most children have a milder disease course than adults but possibly more pronounced gastrointestinal (GI) symptoms. Given the child's developing immune system, the impact of COVID-19 on disease development may differ compared to adults. This study reviews the potential bi-directional relationship between COVID-19 and GI diseases in children, focusing on common pediatric conditions such as functional GI disorders (FGID), celiac disease (CeD), and inflammatory bowel disease (IBD). Children with GI diseases, in general, and CeD and IBD, in particular, do not seem to have an increased risk of severe COVID-19, including risks of hospitalization, critical care need, and death. While infections are considered candidate environmental factors in both CeD and IBD pathogenesis, and specific infectious agents are known triggers for FGID, there is still not sufficient evidence to implicate COVID-19 in the development of either of these diseases. However, given the scarcity of data and the possible latency period between environmental triggers and disease development, future investigations in this field are warranted.", "doi": "10.1177/17562848231177612", "pmid": "37305380", "labels": {"Category: Health": null, "Funder: VR": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10243097"}, {"db": "pii", "key": "10.1177_17562848231177612"}], "notes": [], "created": "2023-10-04T09:30:39.172Z", "modified": "2023-10-04T10:00:22.818Z"}, {"entity": "publication", "iuid": "b681fae3e4244f0481cfe1fcd6f88761", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b681fae3e4244f0481cfe1fcd6f88761.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b681fae3e4244f0481cfe1fcd6f88761"}}, "title": "Psychiatric and non-psychiatric population vulnerabilities in time of a crisis: the unsuspected aggression factor.", "authors": [{"family": "Martin", "given": "Sylvia", "initials": "S"}, {"family": "Oltra", "given": "Anna", "initials": "A"}, {"family": "Del Monte", "given": "Jonathan", "initials": "J"}], "type": "journal article", "published": "2023-06-01", "journal": {"title": "BMC Psychiatry", "issn": "1471-244X", "issn-l": null, "volume": "23", "issue": "1", "pages": "386"}, "abstract": "In March 2020, France faced a health crisis due to the COVID-19 outbreak that, like previous infectious disease crises, involved high psychological and emotional stress, a series of factors that influenced the ongoing mental health crisis.\r\n\r\nWe recruited 384 respondents to complete an online questionnaire during the second month of isolation: 176 psychotherapy recipients (68 were currently attending psychiatric care) and 208 healthy controls. We measured demographic characteristics, impulsivity, aggression, hopelessness, suicidal risk, and the global level of anxiety and depression in order to estimate potential discrepancies in clinical measures across these populations.\r\n\r\nOur results indicate that the group currently undergoing psychiatric care was prone to loneliness and social isolation. Regarding clinical and nonclinical population, there were differences in suicidal risk, depression, anxiety, and hopelessness but mainly in aggression. Regression analysis also demonstrated that aggression surprisingly influenced anxiety levels. Patients undergoing therapy compared with patients who were not displayed differences only in suicidal risk, anxiety, and hopelessness, with those undergoing therapy having higher scores. The outpatient group undergoing therapy had a significantly lower level of impulsivity. Moreover, the regression to predict anxiety and depression levels from correlated factors highlighted the potentially heightened role of aggression in predicting anxiety in the clinical group.\r\n\r\nNew research into stress reactions should assess other clinical signals, such as aggression, and examine preventive mental health interventions in times of crisis.", "doi": "10.1186/s12888-023-04843-4", "pmid": "37264352", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10234249"}, {"db": "pii", "key": "10.1186/s12888-023-04843-4"}], "notes": [], "created": "2023-10-04T09:32:55.523Z", "modified": "2023-10-04T11:14:18.576Z"}, {"entity": "publication", "iuid": "41efdcff61bd4f449f244b6fd78cd47a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41efdcff61bd4f449f244b6fd78cd47a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41efdcff61bd4f449f244b6fd78cd47a"}}, "title": "Assessing the availability and quality of COVID-19 mortality data in Europe: a comparative analysis.", "authors": [{"family": "Marinkovi\u0107", "given": "Ivan", "initials": "I"}, {"family": "Tramo\u0161ljanin", "given": "Ana", "initials": "A"}, {"family": "Galjak", "given": "Marko", "initials": "M", "orcid": "0000-0002-1756-3083", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13cc17cd42d04f39a19c9c844b825f12.json"}}], "type": "journal article", "published": "2023-06-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": null, "issue": null, "pages": null}, "abstract": "Researching mortality during the COVID-19 pandemic has been challenging due to methodological inconsistencies and the limited availability of vital statistics data. At the beginning of the pandemic, the World Health Organization recommended daily data publication to inform policy response, but these data were often poor. Final data on COVID-19 deaths in many countries are not yet available, especially for 2021. This report shows that many countries have significant inconsistencies between the preliminary number of deaths and what vital statistics and excess mortality indicate. The inconsistencies in the mortality data raise concerns about the reliability of analyses and public health recommendations.", "doi": "10.1093/eurpub/ckad088", "pmid": "37263603", "labels": {"Category: Other": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7188269"}], "notes": [], "created": "2023-10-04T09:31:16.503Z", "modified": "2023-10-04T10:47:07.312Z"}, {"entity": "publication", "iuid": "adc405a737f54f5b931af68fc3b891ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/adc405a737f54f5b931af68fc3b891ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/adc405a737f54f5b931af68fc3b891ae"}}, "title": "Age and sex differences in cause-specific excess mortality and years of life lost associated with COVID-19 infection in the Swedish population.", "authors": [{"family": "Lundberg", "given": "Christina E", "initials": "CE", "orcid": "0000-0002-9062-9982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8800d9296bee40f9b178e8ab8399a993.json"}}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}, {"family": "Brand\u00e9n", "given": "Maria", "initials": "M"}, {"family": "Cronie", "given": "Ottmar", "initials": "O"}, {"family": "Lindgren", "given": "Martin", "initials": "M"}, {"family": "Edqvist", "given": "Jon", "initials": "J"}, {"family": "\u00c5berg", "given": "Maria", "initials": "M"}, {"family": "Adiels", "given": "Martin", "initials": "M"}, {"family": "Rosengren", "given": "Annika", "initials": "A", "orcid": "0000-0002-5409-6605", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9cd943e45dd14e14b5367c0ad1a2b950.json"}}], "type": "journal article", "published": "2023-06-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": null, "issue": null, "pages": null}, "abstract": "Estimating excess mortality and years of life lost (YLL) attributed to coronavirus disease 19 (COVID-19) infection provides a comprehensive picture of the mortality burden on society. We aimed to estimate the impact of the COVID-19 pandemic on age- and sex-specific excess mortality and YLL in Sweden during the first 17 months of the pandemic.\r\n\r\nIn this population-based observational study, we calculated age- and sex-specific excess all-cause mortality and excess YLL during 2020 and the first 5 months of 2021 and cause-specific death [deaths from cardiovascular disease (CVD), cancer, other causes and deaths excluding COVID-19] in 2020 compared with an average baseline for 2017-19 in the whole Swedish population.\r\n\r\nCOVID-19 deaths contributed 9.9% of total deaths (98 441 deaths, 960 305 YLL) in 2020, accounting for 75 151 YLL (7.7 YLL/death). There were 2672 (5.7%) and 1408 (3.0%) excess deaths, and 19 141 (3.8%) and 3596 (0.8%) excess YLL in men and women, respectively. Men aged 65-110 years and women aged 75-110 years were the greatest contributors. Fewer deaths and YLL from CVD, cancer and other causes were observed in 2020 compared with the baseline adjusted to the population size in 2020.\r\n\r\nCompared with the baseline, excess mortality and YLL from all causes were experienced in Sweden during 2020, with a higher excess observed in men than in women, indicating that more men died at a younger age while more women died at older ages than expected. A notable reduction in deaths and YLL due to CVD suggests a displacement effect from CVD to COVID-19.", "doi": "10.1093/eurpub/ckad086", "pmid": "37263601", "labels": {"Category: Health": null, "Funder: VR": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7188268"}], "notes": [], "created": "2023-10-04T09:30:43.855Z", "modified": "2023-10-04T10:02:39.508Z"}, {"entity": "publication", "iuid": "c45d86d4b8694925aaa296723ab7423f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c45d86d4b8694925aaa296723ab7423f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c45d86d4b8694925aaa296723ab7423f"}}, "title": "The macroeconomics of pandemics around the world: Lives versus livelihoods revisited.", "authors": [{"family": "Alm\u00e5s", "given": "Ingvild", "initials": "I"}, {"family": "Bold", "given": "Tessa", "initials": "T"}, {"family": "von Carnap", "given": "Tillmann", "initials": "T"}, {"family": "Ghisolfi", "given": "Selene", "initials": "S"}, {"family": "Sandefur", "given": "Justin", "initials": "J"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "J Dev Econ", "issn": "0304-3878", "issn-l": null, "volume": "163", "issue": null, "pages": "103099"}, "abstract": "The COVID-19 pandemic led governments around the world to impose unprecedented restrictions on economic activity. Were these restrictions equally justified in poorer countries with fewer demographic risk factors and less ability to weather economic shocks? We develop and estimate a fully specified model of the macroeconomy with epidemiological dynamics, incorporating subsistence constraints in consumption and allowing preferences over \"lives versus livelihoods\" to vary with income. Poorer countries' demography pushes them unambiguously toward laxer policies. But because both infected and susceptible agents near the subsistence constraint will remain economically active in the face of infection risk and even to some extent under government containment policies, optimal policy in poorer countries pushes in the opposite direction. Moreover, for reasonable income-elasticities of the value of a statistical life, the model can fully rationalize equally strict or stricter policies in poorer countries.", "doi": "10.1016/j.jdeveco.2023.103099", "pmid": "37151749", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10102539"}, {"db": "pii", "key": "S0304-3878(23)00054-8"}], "notes": [], "created": "2023-10-04T05:12:09.277Z", "modified": "2023-10-04T07:30:00.817Z"}, {"entity": "publication", "iuid": "3b523ea9895b42db95bb6286ef80952b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b523ea9895b42db95bb6286ef80952b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b523ea9895b42db95bb6286ef80952b"}}, "title": "The IHI Rochester Report 2022 on Healthcare Informatics Research: Resuming After the CoViD-19.", "authors": [{"family": "Combi", "given": "Carlo", "initials": "C"}, {"family": "Facelli", "given": "Julio C", "initials": "JC"}, {"family": "Haddawy", "given": "Peter", "initials": "P"}, {"family": "Holmes", "given": "John H", "initials": "JH"}, {"family": "Koch", "given": "Sabine", "initials": "S"}, {"family": "Liu", "given": "Hongfang", "initials": "H"}, {"family": "Meyer", "given": "Jochen", "initials": "J"}, {"family": "Peleg", "given": "Mor", "initials": "M"}, {"family": "Pozzi", "given": "Giuseppe", "initials": "G"}, {"family": "Stiglic", "given": "Gregor", "initials": "G"}, {"family": "Veltri", "given": "Pierangelo", "initials": "P"}, {"family": "Yang", "given": "Christopher C", "initials": "CC"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "J Healthc Inform Res", "issn": "2509-4971", "issn-l": null, "volume": "7", "issue": "2", "pages": "169-202"}, "abstract": "In 2020, the CoViD-19 pandemic spread worldwide in an unexpected way and suddenly modified many life issues, including social habits, social relationships, teaching modalities, and more. Such changes were also observable in many different healthcare and medical contexts. Moreover, the CoViD-19 pandemic acted as a stress test for many research endeavors, and revealed some limitations, especially in contexts where research results had an immediate impact on the social and healthcare habits of millions of people. As a result, the research community is called to perform a deep analysis of the steps already taken, and to re-think steps for the near and far future to capitalize on the lessons learned due to the pandemic. In this direction, on June 09th-11th, 2022, a group of twelve healthcare informatics researchers met in Rochester, MN, USA. This meeting was initiated by the Institute for Healthcare Informatics-IHI, and hosted by the Mayo Clinic. The goal of the meeting was to discuss and propose a research agenda for biomedical and health informatics for the next decade, in light of the changes and the lessons learned from the CoViD-19 pandemic. This article reports the main topics discussed and the conclusions reached. The intended readers of this paper, besides the biomedical and health informatics research community, are all those stakeholders in academia, industry, and government, who could benefit from the new research findings in biomedical and health informatics research. Indeed, research directions and social and policy implications are the main focus of the research agenda we propose, according to three levels: the care of individuals, the healthcare system view, and the population view.", "doi": "10.1007/s41666-023-00126-5", "pmid": "37359193", "labels": {"Funder: H2020": null, "Type: Other": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10150351"}, {"db": "pii", "key": "126"}], "notes": [], "created": "2023-10-04T09:32:16.624Z", "modified": "2023-10-04T11:01:01.548Z"}, {"entity": "publication", "iuid": "caa0cd6c9f3c41b49d6c8db447f9de06", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/caa0cd6c9f3c41b49d6c8db447f9de06.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/caa0cd6c9f3c41b49d6c8db447f9de06"}}, "title": "New urban habits in Stockholm following COVID-19.", "authors": [{"family": "Legeby", "given": "Ann", "initials": "A", "orcid": "0000-0002-3173-853X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cbe1819ded8340b7a9712da118ce8c12.json"}}, {"family": "Koch", "given": "Daniel", "initials": "D"}, {"family": "Duarte", "given": "F\u00e1bio", "initials": "F", "orcid": "0000-0003-0909-5379", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/527c769b3b2143e99e126eb2af7ecd4e.json"}}, {"family": "Heine", "given": "Cate", "initials": "C"}, {"family": "Benson", "given": "Tom", "initials": "T"}, {"family": "Fugiglando", "given": "Umberto", "initials": "U", "orcid": "0000-0001-6527-8968", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05008e7f430d4dccbe1e060d65ba9178.json"}}, {"family": "Ratti", "given": "Carlo", "initials": "C"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Urban Stud", "issn": "0042-0980", "issn-l": null, "volume": "60", "issue": "8", "pages": "1448-1464"}, "abstract": "During the COVID-19 pandemic, physical distancing, mobility restrictions and self-isolation measures were implemented around the world as the primary intervention to prevent the virus from spreading. Urban life has undergone sweeping changes, with people using spaces in new ways. Stockholm is a particularly relevant case of this phenomenon since most facilities, such as day care centres and schools, have remained open, in contrast to cities with a broader lockdown. In this study, we use Twitter data and an online map survey to study how COVID-19 restrictions have impacted the use of different locations, services and amenities in Stockholm. First, we compare the spatial distribution of 87,000 geolocated tweets pre-COVID-19 and during the COVID-19 pandemic. Second, we analyse 895 survey responses asking people to identify places they 'still visit', 'use more', 'avoid' and self-report reasons for using locations. The survey provides a nuanced understanding of whether and how restrictions have affected people. Service and seclusion were found to be important; therefore, the accessibility of such amenities was analysed, demonstrating how changes in urban habits are related to conditions of the local environment. We find how different parts of the city show different capacities to accommodate new habits and mitigate the effects of restrictions on people's use of urban spaces. In addition to the immediate relevance to COVID-19, this paper thus contributes to understanding how restrictions on movement and gathering, in any situation, expose more profound urban challenges related to segregation and social inequality.", "doi": "10.1177/00420980211070677", "pmid": "37273493", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10230291"}, {"db": "pii", "key": "10.1177_00420980211070677"}], "notes": [], "created": "2023-10-04T09:32:39.460Z", "modified": "2023-10-04T11:12:45.336Z"}, {"entity": "publication", "iuid": "46fc0cdf480a4887a1989d1e245cf463", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46fc0cdf480a4887a1989d1e245cf463.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46fc0cdf480a4887a1989d1e245cf463"}}, "title": "Job loss and job instability during the COVID-19 pandemic and the risk of depression and anxiety among Swedish employees.", "authors": [{"family": "Blomqvist", "given": "Sandra", "initials": "S"}, {"family": "H\u00f6gn\u00e4s", "given": "Robin S", "initials": "RS"}, {"family": "Virtanen", "given": "Marianna", "initials": "M"}, {"family": "LaMontagne", "given": "Anthony D", "initials": "AD"}, {"family": "Magnusson Hanson", "given": "Linda L", "initials": "LL"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "SSM Popul Health", "issn": "2352-8273", "issn-l": null, "volume": "22", "issue": null, "pages": "101424"}, "abstract": "The COVID-19 pandemic led to permanent and temporary job losses but the mental health consequences of different types of employment transitions are not well-understood. In particular, knowledge is scarce concerning furloughs, which was a common job protection strategy in many high- and upper middle-income countries during this crisis. This study focuses on how different types of job instability and job loss during the pandemic influences depression and anxiety in the context of Sweden. A subset of participants from the Swedish Longitudinal Occupational Survey of Health were contacted in February 2021 and again in February 2022. A total of 1558 individuals participated in either or both waves and worked before the pandemic. We examined whether i) workplace downsizing, ii) furlough, or iii) unemployment/job loss were associated with depression and anxiety over this one-year period during the pandemic. Logistic regression models with cluster-robust standard errors were estimated, adjusting for sociodemographic factors and prior mental health problems. Effect modification by sex and prior mental health problems was also examined. In comparison to stable employment, being furloughed was unrelated to mental health, while experiencing workplace downsizing during the pandemic was associated with an increased risk of anxiety (adjusted Odds Ratio (OR) = 2.09, 95% Confidence interval (CI) = 1.08-4.05). Job loss/unemployment increased the risk of depression (OR = 1.91, 95% CI = 1.02-3.57) compared to being stably employed, but the risk estimate crossed unity when considering prior mental health status. No effect modification by sex or by prior mental health problems was found. This study found that while job loss and downsizing during the COVID-19 pandemic were associated with depression and anxiety, respectively, being furloughed was not. These findings thus suggest that job retention schemes in the form of short-time work allowances, as implemented in Sweden during the COVID-19 pandemic, may prevent mental health problems among employees during economic crises.", "doi": "10.1016/j.ssmph.2023.101424", "pmid": "37159634", "labels": {"Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10158169"}, {"db": "pii", "key": "S2352-8273(23)00089-7"}], "notes": [], "created": "2023-10-04T05:11:24.229Z", "modified": "2023-10-04T07:11:22.409Z"}, {"entity": "publication", "iuid": "4456be75b63f4527b96167b7ef4a4631", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4456be75b63f4527b96167b7ef4a4631.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4456be75b63f4527b96167b7ef4a4631"}}, "title": "In vitro high-content tissue models to address precision medicine challenges.", "authors": [{"family": "Afewerki", "given": "Samson", "initials": "S"}, {"family": "Stocco", "given": "Thiago Domingues", "initials": "TD"}, {"family": "Rosa da Silva", "given": "Andr\u00e9 Diniz", "initials": "AD"}, {"family": "Aguiar Furtado", "given": "Andr\u00e9 Sales", "initials": "AS"}, {"family": "Fernandes de Sousa", "given": "Gustavo", "initials": "G"}, {"family": "Ruiz-Esparza", "given": "Guillermo U", "initials": "GU"}, {"family": "Webster", "given": "Thomas J", "initials": "TJ"}, {"family": "Marciano", "given": "Fernanda R", "initials": "FR"}, {"family": "Str\u00f8mme", "given": "Maria", "initials": "M"}, {"family": "Zhang", "given": "Yu Shrike", "initials": "YS", "orcid": "0000-0002-0045-0808", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a7c59d189474a49a590ae7fcb4f294d.json"}}, {"family": "Lobo", "given": "Anderson Oliveira", "initials": "AO"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Mol Aspects Med", "issn": "1872-9452", "pages": "101108", "volume": "91", "issn-l": null}, "abstract": "The field of precision medicine allows for tailor-made treatments specific to a patient and thereby improve the efficiency and accuracy of disease prevention, diagnosis, and treatment and at the same time would reduce the cost, redundant treatment, and side effects of current treatments. Here, the combination of organ-on-a-chip and bioprinting into engineering high-content in vitro tissue models is envisioned to address some precision medicine challenges. This strategy could be employed to tackle the current coronavirus disease 2019 (COVID-19), which has made a significant impact and paradigm shift in our society. Nevertheless, despite that vaccines against COVID-19 have been successfully developed and vaccination programs are already being deployed worldwide, it will likely require some time before it is available to everyone. Furthermore, there are still some uncertainties and lack of a full understanding of the virus as demonstrated in the high number new mutations arising worldwide and reinfections of already vaccinated individuals. To this end, efficient diagnostic tools and treatments are still urgently needed. In this context, the convergence of bioprinting and organ-on-a-chip technologies, either used alone or in combination, could possibly function as a prominent tool in addressing the current pandemic. This could enable facile advances of important tools, diagnostics, and better physiologically representative in vitro models specific to individuals allowing for faster and more accurate screening of therapeutics evaluating their efficacy and toxicity. This review will cover such technological advances and highlight what is needed for the field to mature for tackling the various needs for current and future pandemics as well as their relevancy towards precision medicine.", "doi": "10.1016/j.mam.2022.101108", "pmid": "35987701", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9384546"}, {"db": "pii", "key": "S0098-2997(22)00053-X"}], "notes": [], "created": "2022-09-12T18:48:08.519Z", "modified": "2023-06-19T15:33:47.094Z"}, {"entity": "publication", "iuid": "7bcff8cad7644b8080abab3d4e51f599", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7bcff8cad7644b8080abab3d4e51f599.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7bcff8cad7644b8080abab3d4e51f599"}}, "title": "High Prevalence of SARS-CoV-2 Omicron Infection Despite High Seroprevalence, Sweden, 2022.", "authors": [{"family": "Groenheit", "given": "Ramona", "initials": "R"}, {"family": "Bacchus", "given": "Philip", "initials": "P"}, {"family": "Galanis", "given": "Ilias", "initials": "I"}, {"family": "Sond\u00e9n", "given": "Klara", "initials": "K"}, {"family": "Bujila", "given": "Ioana", "initials": "I"}, {"family": "Efimova", "given": "Tatiana", "initials": "T"}, {"family": "Garli", "given": "Fredrik", "initials": "F"}, {"family": "Lindsj\u00f6", "given": "Oskar Karlsson", "initials": "OK"}, {"family": "Mansj\u00f6", "given": "Mikael", "initials": "M"}, {"family": "Movert", "given": "Elin", "initials": "E"}, {"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Rapp", "given": "Marie", "initials": "M"}, {"family": "Sperk", "given": "Maike", "initials": "M"}, {"family": "S\u00f6derholm", "given": "Sandra", "initials": "S"}, {"family": "Asin", "given": "Karin Valentin", "initials": "KV"}, {"family": "Zanetti", "given": "Sarah", "initials": "S"}, {"family": "Karlberg", "given": "Maria Lind", "initials": "ML"}, {"family": "Br\u00e5ve", "given": "Andreas", "initials": "A"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Emerg Infect Dis", "issn": "1080-6059", "volume": "29", "issue": "6", "pages": "1240-1243", "issn-l": null}, "abstract": "We performed 2 surveys during 2022 to estimate point prevalences of SARS-CoV-2 infection compared with overall seroprevalence in Sweden. Point prevalence was 1.4% in March and 1.5% in September. Estimated seroprevalence was >80%, including among unvaccinated children. Continued SARS-CoV-2 surveillance is necessary for detecting emerging, possibly more pathogenic variants.", "doi": "10.3201/eid2906.221862", "pmid": "37141616", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC10202879"}], "notes": [], "created": "2023-07-13T11:37:13.361Z", "modified": "2023-07-13T11:37:13.365Z"}, {"entity": "publication", "iuid": "6336bc6ca2c14794b41168651fdfdaf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6336bc6ca2c14794b41168651fdfdaf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6336bc6ca2c14794b41168651fdfdaf3"}}, "title": "Establishing severe acute respiratory infection (SARI) surveillance in a sentinel hospital, Ireland, 2021 to 2022.", "authors": [{"family": "Brady", "given": "Melissa", "initials": "M"}, {"family": "Duffy", "given": "Roisin", "initials": "R"}, {"family": "Domegan", "given": "Lisa", "initials": "L"}, {"family": "Salmon", "given": "Abigail", "initials": "A"}, {"family": "Maharjan", "given": "Binita", "initials": "B"}, {"family": "O'Broin", "given": "Cathal", "initials": "C"}, {"family": "Bennett", "given": "Charlene", "initials": "C"}, {"family": "Christle", "given": "James", "initials": "J"}, {"family": "Connell", "given": "Jeff", "initials": "J"}, {"family": "Feeney", "given": "Laura", "initials": "L"}, {"family": "Nurdin", "given": "Nadra", "initials": "N"}, {"family": "Mallon", "given": "Patrick", "initials": "P"}, {"family": "Doran", "given": "Peter", "initials": "P"}, {"family": "McNamara", "given": "Rosa", "initials": "R"}, {"family": "O'Grady", "given": "Sarah", "initials": "S"}, {"family": "McDermott", "given": "Sinead", "initials": "S"}, {"family": "Petty-Saphon", "given": "Naomi", "initials": "N"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "23", "pages": null}, "abstract": "BackgroundIn 2020, due to the COVID-19 pandemic, the European Centre for Disease Prevention and Control (ECDC) accelerated development of European-level severe acute respiratory infection (SARI) surveillance.AimWe aimed to establish SARI surveillance in one Irish hospital as part of a European network E-SARI-NET.MethodsWe used routine emergency department records to identify cases in one adult acute hospital. The SARI case definition was adapted from the ECDC clinical criteria for a possible COVID-19 case. Clinical data were collected using an online questionnaire. Cases were tested for SARS-CoV-2, influenza and respiratory syncytial virus (RSV), including whole genome sequencing (WGS) on SARS-CoV-2 RNA-positive samples and viral characterisation/sequencing on influenza RNA-positive samples. Descriptive analysis was conducted for SARI cases hospitalised between July 2021 and April 2022.ResultsOverall, we identified 437 SARI cases, the incidence ranged from two to 28 cases per week (0.7-9.2/100,000 hospital catchment population). Of 431 cases tested for SARS-CoV-2 RNA, 226 (52%) were positive. Of 349 (80%) cases tested for influenza and RSV RNA, 15 (4.3%) were positive for influenza and eight (2.3%) for RSV. Using WGS, we identified Delta- and Omicron-dominant periods. The resource-intensive nature of manual clinical data collection, specimen management and laboratory supply shortages for influenza and RSV testing were challenging.ConclusionWe successfully established SARI surveillance as part of E-SARI-NET. Expansion to additional sentinel sites is planned following formal evaluation of the existing system. SARI surveillance requires multidisciplinary collaboration, automated data collection where possible, and dedicated personnel resources, including for specimen management.", "doi": "10.2807/1560-7917.ES.2023.28.23.2200740", "pmid": "37289427", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10318943"}], "notes": [], "created": "2023-10-04T09:30:04.862Z", "modified": "2023-10-04T09:47:34.315Z"}, {"entity": "publication", "iuid": "99d71e90a9a64e30a3fdf43372df352c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/99d71e90a9a64e30a3fdf43372df352c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/99d71e90a9a64e30a3fdf43372df352c"}}, "title": "Differences in incidence, nature of symptoms, and duration of long COVID among hospitalised migrant and non-migrant patients in the Netherlands: a retrospective cohort study.", "authors": [{"family": "Chilunga", "given": "Felix Patience", "initials": "FP"}, {"family": "Appelman", "given": "Brent", "initials": "B"}, {"family": "van Vugt", "given": "Michele", "initials": "M"}, {"family": "Kalverda", "given": "Kirsten", "initials": "K"}, {"family": "Smeele", "given": "Patrick", "initials": "P"}, {"family": "van Es", "given": "Josien", "initials": "J"}, {"family": "Wiersinga", "given": "Willem Joost", "initials": "WJ"}, {"family": "Rostila", "given": "Mikael", "initials": "M"}, {"family": "Prins", "given": "Maria", "initials": "M"}, {"family": "Stronks", "given": "Karien", "initials": "K"}, {"family": "Norredam", "given": "Marie", "initials": "M"}, {"family": "Agyemang", "given": "Charles", "initials": "C"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "issn-l": null, "volume": "29", "issue": null, "pages": "100630"}, "abstract": "Comprehensive data on long COVID across ethnic and migrant groups are lacking. We investigated incidence, nature of symptoms, clinical predictors, and duration of long COVID among COVID-19 hospitalised patients in the Netherlands by migration background (Dutch, Turkish, Moroccan, and Surinamese origin, Others).\r\n\r\nWe used COVID-19 admissions and follow up data (January 2021-July 2022) from Amsterdam University Medical Centers. We calculated long COVID incidence proportions per NICE guidelines by migration background and assessed for clinical predictors via robust Poisson regressions. We then examined associations between migration background and long COVID using robust Poisson regressions and adjusted for derived clinical predictors, and other biologically relevant factors. We also assessed long COVID symptom persistence at one-year post-discharge.\r\n\r\n1886 patients were included. 483 patients had long COVID (26%, 95% CI 24-28%) at 12 weeks post-discharge. Symptoms like dizziness, joint pain, insomnia, and headache varied by migration background. Clinical predictors of long COVID were female sex, hospital admission duration, intensive care unit admission, and receiving oxygen, or corticosteroid therapy. Long COVID risk was higher among patients with migration background than Dutch origin patients after adjustments for derived clinical predictors, age, smoking, vaccination status, comorbidities and remdesivir treatment. Only 14% of long COVID symptoms persisted at one-year post-discharge.\r\n\r\nThere are significant differences in occurrence, nature of symptoms, and duration of long COVID by migration background. Studies assessing the spectrum of functional limitation and access to post-COVID healthcare are needed to help plan for appropriate and accessible healthcare interventions.\r\n\r\nThe Amsterdam UMC COVID-19 biobank is supported by the Amsterdam UMC Corona Research Fund and the Talud Foundation (Stichting Talud). The current analyses were supported by the Novo Nordisk Foundation [NNF21OC0067528].", "doi": "10.1016/j.lanepe.2023.100630", "pmid": "37261215", "labels": {"Category: Post-COVID": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10079482"}, {"db": "pii", "key": "S2666-7762(23)00049-2"}], "notes": [], "created": "2023-10-04T09:32:34.156Z", "modified": "2023-10-04T11:11:02.084Z"}, {"entity": "publication", "iuid": "611d3dec80a4496989e28b0aad6ac03d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/611d3dec80a4496989e28b0aad6ac03d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/611d3dec80a4496989e28b0aad6ac03d"}}, "title": "COVID-19 infection in patients on long-term home parenteral nutrition for chronic intestinal failure.", "authors": [{"family": "Pironi", "given": "Loris", "initials": "L"}, {"family": "Jezerski", "given": "Denise", "initials": "D"}, {"family": "Sobocki", "given": "Jacek", "initials": "J"}, {"family": "Lal", "given": "Simon", "initials": "S"}, {"family": "Vanuytsel", "given": "Tim", "initials": "T"}, {"family": "Theilla", "given": "Miriam", "initials": "M"}, {"family": "Sasdelli", "given": "Anna S", "initials": "AS"}, {"family": "Chambrier", "given": "Cecile", "initials": "C"}, {"family": "Matysiak", "given": "Konrad", "initials": "K"}, {"family": "Aimasso", "given": "Umberto", "initials": "U"}, {"family": "Rasmussen", "given": "Henrik H", "initials": "HH"}, {"family": "Jukes", "given": "Amelia", "initials": "A"}, {"family": "Kunecki", "given": "Marek", "initials": "M"}, {"family": "Seguy", "given": "David", "initials": "D"}, {"family": "Schneider", "given": "St\u00e9phane M", "initials": "SM"}, {"family": "Daniels", "given": "Joanne", "initials": "J"}, {"family": "Poullenot", "given": "Florian", "initials": "F"}, {"family": "Mundi", "given": "Manpreet S", "initials": "MS"}, {"family": "Matras", "given": "Przemys\u0142aw", "initials": "P"}, {"family": "Folwarski", "given": "Marcin", "initials": "M"}, {"family": "Crivelli", "given": "Adriana", "initials": "A"}, {"family": "Wyer", "given": "Nicola", "initials": "N"}, {"family": "Ellegard", "given": "Lars", "initials": "L"}, {"family": "Santarpia", "given": "Lidia", "initials": "L"}, {"family": "Arvanitakis", "given": "Marianna", "initials": "M"}, {"family": "Spaggiari", "given": "Corrado", "initials": "C"}, {"family": "Lamprecht", "given": "Georg", "initials": "G"}, {"family": "Guglielmi", "given": "Francesco W", "initials": "FW"}, {"family": "Lezo", "given": "Antonella", "initials": "A"}, {"family": "Layec", "given": "Sabrina", "initials": "S"}, {"family": "Boluda", "given": "Esther Ramos", "initials": "ER"}, {"family": "Guz-Mark", "given": "Anat", "initials": "A"}, {"family": "Gandullia", "given": "Paolo", "initials": "P"}, {"family": "Cuerda", "given": "Cristina", "initials": "C"}, {"family": "Osland", "given": "Emma", "initials": "E"}, {"family": "Spagnuolo", "given": "Maria I", "initials": "MI"}, {"family": "Krznaric", "given": "Zeljko", "initials": "Z"}, {"family": "Masconale", "given": "Luisa", "initials": "L"}, {"family": "Chapman", "given": "Brooke", "initials": "B"}, {"family": "Ma\u00edz-Jim\u00e9nez", "given": "Mar\u00eda", "initials": "M"}, {"family": "Orlandoni", "given": "Paolo", "initials": "P"}, {"family": "Martins da Rocha", "given": "Mariana Hollanda", "initials": "MH"}, {"family": "Virgili-Casas", "given": "M Nuria", "initials": "MN"}, {"family": "Doitchinova-Simeonova", "given": "Maryana", "initials": "M"}, {"family": "Czako", "given": "Laszlo", "initials": "L"}, {"family": "Van Gossum", "given": "Andr\u00e8", "initials": "A"}, {"family": "D'Antiga", "given": "Lorenzo", "initials": "L"}, {"family": "Ee", "given": "Looi C", "initials": "LC"}, {"family": "Warodomwichit", "given": "Daruneewan", "initials": "D"}, {"family": "Taus", "given": "Marina", "initials": "M"}, {"family": "Kola\u010dek", "given": "Sanja", "initials": "S"}, {"family": "Thibault", "given": "Ronan", "initials": "R"}, {"family": "Verlato", "given": "Giovanna", "initials": "G"}, {"family": "Serralde-Z\u00fa\u00f1iga", "given": "Aurora E", "initials": "AE"}, {"family": "Botella-Carretero", "given": "Jos\u00e9 I", "initials": "JI"}, {"family": "Aguayo", "given": "Pilar Serrano", "initials": "PS"}, {"family": "Olveira", "given": "Gabriel", "initials": "G"}, {"family": "Chomtho", "given": "Sirinuch", "initials": "S"}, {"family": "Pisprasert", "given": "Veeradej", "initials": "V"}, {"family": "Moisejevs", "given": "Georgijs", "initials": "G"}, {"family": "Murillo", "given": "Ana Zugasti", "initials": "AZ"}, {"family": "J\u00e1uregui", "given": "Ma Estrella Petrina", "initials": "MEP"}, {"family": "D\u00edez", "given": "Marta Bueno", "initials": "MB"}, {"family": "Jahit", "given": "Mohammad Shukri", "initials": "MS"}, {"family": "Densupsoontorn", "given": "Narumon", "initials": "N"}, {"family": "Tamer", "given": "Ali", "initials": "A"}, {"family": "Brillanti", "given": "Giorgia", "initials": "G"}, {"family": "Joly", "given": "Francisca", "initials": "F"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Clin Nutr ESPEN", "issn": "2405-4577", "issn-l": null, "volume": "55", "issue": null, "pages": "212-220"}, "abstract": "To investigate the incidence and the severity of COVID-19 infection in patients enrolled in the database for home parenteral nutrition (HPN) for chronic intestinal failure (CIF) of the European Society for Clinical Nutrition and Metabolism (ESPEN).\r\n\r\nPeriod of observation: March 1st, 2020 March 1st, 2021.\r\n\r\npatients included in the database since 2015 and still receiving HPN on March 1st, 2020 as well as new patients included in the database during the period of observation. Data related to the previous 12 months and recorded on March 1st 2021: 1) occurrence of COVID-19 infection since the beginning of the pandemic (yes, no, unknown); 2) infection severity (asymptomatic; mild, no-hospitalization; moderate, hospitalization no-ICU; severe, hospitalization in ICU); 3) vaccinated against COVID-19 (yes, no, unknown); 4) patient outcome on March 1st 2021: still on HPN, weaned off HPN, deceased, lost to follow up.\r\n\r\nSixty-eight centres from 23 countries included 4680 patients. Data on COVID-19 were available for 55.1% of patients. The cumulative incidence of infection was 9.6% in the total group and ranged from 0% to 21.9% in the cohorts of individual countries. Infection severity was reported as: asymptomatic 26.7%, mild 32.0%, moderate 36.0%, severe 5.3%. Vaccination status was unknown in 62.0% of patients, non-vaccinated 25.2%, vaccinated 12.8%. Patient outcome was reported as: still on HPN 78.6%, weaned off HPN 10.6%, deceased 9.7%, lost to follow up 1.1%. A higher incidence of infection (p = 0.04), greater severity of infection (p < 0.001) and a lower vaccination percentage (p = 0.01) were observed in deceased patients. In COVID-19 infected patients, deaths due to infection accounted for 42.8% of total deaths.\r\n\r\nIn patients on HPN for CIF, the incidence of COVID-19 infection differed greatly among countries. Although the majority of cases were reported to be asymptomatic or have mild symptoms only, COVID-19 was reported to be fatal in a significant proportion of infected patients. Lack of vaccination was associated with a higher risk of death.", "doi": "10.1016/j.clnesp.2023.03.008", "pmid": "37202049", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10060187"}, {"db": "pii", "key": "S2405-4577(23)00075-X"}], "notes": [], "created": "2023-10-04T05:11:29.125Z", "modified": "2023-10-04T07:13:30.687Z"}, {"entity": "publication", "iuid": "19c8f56c67384179ae91bca3ce302683", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19c8f56c67384179ae91bca3ce302683.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19c8f56c67384179ae91bca3ce302683"}}, "title": "COVID-19 and unintended steps towards further equity in global health research.", "authors": [{"family": "Willows", "given": "Tamara Mulenga", "initials": "TM", "orcid": "0000-0003-0760-5574", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a81a219f7e1647789a38f3bdfd754b16.json"}}, {"family": "Oliwa", "given": "Jacquie", "initials": "J"}, {"family": "Onyango", "given": "Onesmus", "initials": "O"}, {"family": "Mkumbo", "given": "Elibariki", "initials": "E"}, {"family": "Maiba", "given": "John", "initials": "J"}, {"family": "Schell", "given": "Carl Otto", "initials": "CO", "orcid": "0000-0002-7904-1336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a40b337b45b471d97a102c355c9d874.json"}}, {"family": "Baker", "given": "Tim", "initials": "T", "orcid": "0000-0001-8727-7018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1454fc20049b4d47865268adf16d104a.json"}}, {"family": "McKnight", "given": "Jacob", "initials": "J", "orcid": "0000-0003-1340-2618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ab57e6a797048338416851ae43170a9.json"}}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "issn-l": "2059-7908", "volume": "8", "issue": "6", "pages": null}, "abstract": "There was, and possibly still is, potential for COVID-19 to disrupt power inequities and contribute to positive transformation in global health research that increases equity. While there is consensus about the need to decolonise by transforming global health, and a roadmap outlining how we could approach it, there are few examples of steps that could be taken to transform the mechanics of global health research. This paper contributes lessons learnt from experiences and reflections of our diverse multinational team of researchers involved in a multicountry research project. We demonstrate the positive impact on our research project of making further steps towards improving equity within our research practices. Some of the approaches adopted include redistributing power to researchers from the countries of interest at various stages in their career, by involving the whole team in decisions about the research; meaningfully involving the whole team in research data analysis; and providing opportunities for all researchers from the countries of interest to voice their perspectives as first authors in publications. Although this approach is consistent with how research guidance suggests research should be run, in reality it does not often happen in this way. The authors of this paper hope that by sharing our experience, we can contribute towards discussions about the processes required to continue developing a global health sector that is equitable and inclusive.", "doi": "10.1136/bmjgh-2023-011888", "pmid": "37328283", "labels": {"Type: Other": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10276961"}, {"db": "pii", "key": "bmjgh-2023-011888"}], "notes": [], "created": "2023-10-04T09:33:08.709Z", "modified": "2023-10-04T11:17:35.824Z"}, {"entity": "publication", "iuid": "3dafb03d45fe4acdb6cd32d1298d72af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3dafb03d45fe4acdb6cd32d1298d72af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3dafb03d45fe4acdb6cd32d1298d72af"}}, "title": "A comprehensive health effects assessment of the use of sanitizers and disinfectants during COVID-19 pandemic: a global survey.", "authors": [{"family": "Hashemi", "given": "Fallah", "initials": "F"}, {"family": "Hoepner", "given": "Lori", "initials": "L"}, {"family": "Hamidinejad", "given": "Farahnaz Soleimani", "initials": "FS"}, {"family": "Haluza", "given": "Daniela", "initials": "D"}, {"family": "Afrashteh", "given": "Sima", "initials": "S"}, {"family": "Abbasi", "given": "Alireza", "initials": "A"}, {"family": "Omeragi\u0107", "given": "Elma", "initials": "E"}, {"family": "Imamovi\u0107", "given": "Belma", "initials": "B"}, {"family": "Rasheed", "given": "Narin A", "initials": "NA"}, {"family": "Taher", "given": "Taqi M J", "initials": "TMJ"}, {"family": "Kurniasari", "given": "Fitri", "initials": "F"}, {"family": "Wazqar", "given": "Dhuha Youssef", "initials": "DY"}, {"family": "Apal\u0131", "given": "\u00d6zge Ceren", "initials": "\u00d6C"}, {"family": "Yildirim", "given": "Ayca Demir", "initials": "AD"}, {"family": "Zhao", "given": "Bo", "initials": "B"}, {"family": "Kalikyan", "given": "Zaruhi", "initials": "Z"}, {"family": "Guo", "given": "Cui", "initials": "C"}, {"family": "Valbuena", "given": "Andrea Chong", "initials": "AC"}, {"family": "Mititelu", "given": "Magdalena", "initials": "M"}, {"family": "Pando", "given": "Carolina Mart\u00ednez", "initials": "CM"}, {"family": "Saridi", "given": "Maria", "initials": "M"}, {"family": "Toska", "given": "Aikaterini", "initials": "A"}, {"family": "Cuba", "given": "Magalys Lopez", "initials": "ML"}, {"family": "Kwadzokpui", "given": "Precious Kwablah", "initials": "PK"}, {"family": "Tadele", "given": "Niguse", "initials": "N"}, {"family": "Nasibova", "given": "Tohfa", "initials": "T"}, {"family": "Harsch", "given": "Stefanie", "initials": "S"}, {"family": "Munkh-Erdene", "given": "Luvsan", "initials": "L"}, {"family": "Menawi", "given": "Wafaa", "initials": "W"}, {"family": "Evangelou", "given": "Efi", "initials": "E"}, {"family": "Dimova", "given": "Antoniya", "initials": "A"}, {"family": "Marinov", "given": "Dimitar", "initials": "D"}, {"family": "Dimitrova", "given": "Teodora", "initials": "T"}, {"family": "Shalimova", "given": "Anna", "initials": "A"}, {"family": "Fouly", "given": "Howieda", "initials": "H"}, {"family": "Suraya", "given": "Anna", "initials": "A"}, {"family": "da Silva Faquim", "given": "Juliana Pereira", "initials": "JP"}, {"family": "Oumayma", "given": "Bouadil", "initials": "B"}, {"family": "Annunziato", "given": "Maria Antonieta", "initials": "MA"}, {"family": "Lalo", "given": "Rezarta", "initials": "R"}, {"family": "Papastavrou", "given": "Evridiki", "initials": "E"}, {"family": "Ade", "given": "Anju D", "initials": "AD"}, {"family": "Caminada", "given": "Susanna", "initials": "S"}, {"family": "Stojkov", "given": "Svetlana", "initials": "S"}, {"family": "Narvaez", "given": "Carmen Gloria", "initials": "CG"}, {"family": "Mudau", "given": "Lutendo Sylvia", "initials": "LS"}, {"family": "Rassas", "given": "Ines", "initials": "I"}, {"family": "Michel", "given": "Daphnee", "initials": "D"}, {"family": "Kaynar", "given": "Nur Sema", "initials": "NS"}, {"family": "Iqbal", "given": "Sehar", "initials": "S"}, {"family": "Elshwekh", "given": "Halla", "initials": "H"}, {"family": "Hossain", "given": "Irin", "initials": "I"}, {"family": "Al-Fayyadh", "given": "Sadeq", "initials": "S"}, {"family": "Sydorchuk", "given": "Aniuta", "initials": "A"}, {"family": "Alnusairat", "given": "Dua'a M H", "initials": "DMH"}, {"family": "Abdullahi", "given": "Asli Mohamed", "initials": "AM"}, {"family": "Iqbal", "given": "Neelam", "initials": "N"}, {"family": "Pandey", "given": "Apsara", "initials": "A"}, {"family": "G\u00f3mez-G\u00f3mez", "given": "Brenda", "initials": "B"}, {"family": "Akyildiz", "given": "Aysenur Gunaydin", "initials": "AG"}, {"family": "Morosan", "given": "Elena", "initials": "E"}, {"family": "Dwarica", "given": "Daniella", "initials": "D"}, {"family": "Dorj", "given": "Gantuya", "initials": "G"}, {"family": "Hasan", "given": "Sumaya Yusuf", "initials": "SY"}, {"family": "Al-Shdayfat", "given": "Noha M", "initials": "NM"}, {"family": "Knezevic", "given": "Bojana", "initials": "B"}, {"family": "Valladares", "given": "Wendy", "initials": "W"}, {"family": "Severi", "given": "Cecilia", "initials": "C"}, {"family": "Fuentes", "given": "Sofia Cuba", "initials": "SC"}, {"family": "Augusto", "given": "Sofia", "initials": "S"}, {"family": "Sidorova", "given": "Elizaveta", "initials": "E"}, {"family": "Moelyaningrum", "given": "Anita Dewi", "initials": "AD"}, {"family": "Alawad", "given": "Tafaul", "initials": "T"}, {"family": "Khalid", "given": "Atiqa", "initials": "A"}, {"family": "Elehamer", "given": "Nafisa M K", "initials": "NMK"}, {"family": "Mihaylova", "given": "Anna", "initials": "A"}, {"family": "Tsigengagel", "given": "Oxana", "initials": "O"}, {"family": "Menouni", "given": "Aziza", "initials": "A"}, {"family": "Wojtecka", "given": "Agnieszka", "initials": "A"}, {"family": "Hod", "given": "Rozita", "initials": "R"}, {"family": "Idayat", "given": "Yusuf Banke", "initials": "YB"}, {"family": "Othman", "given": "Khadija", "initials": "K"}, {"family": "Harfouch", "given": "Rim M", "initials": "RM"}, {"family": "Paunov", "given": "Tsonco", "initials": "T"}, {"family": "Omar", "given": "Meruyert", "initials": "M"}, {"family": "Benderli", "given": "Nana Christine", "initials": "NC"}, {"family": "Nurika", "given": "Globila", "initials": "G"}, {"family": "Amjad", "given": "Sana", "initials": "S"}, {"family": "Elnoamany", "given": "Salma", "initials": "S"}, {"family": "Elesrigy", "given": "Fatma", "initials": "F"}, {"family": "Shaban", "given": "Marwa Mamdouh", "initials": "MM"}, {"family": "Acevedo-L\u00f3pez", "given": "Dom\u00e9nica", "initials": "D"}, {"family": "Kartashova", "given": "Maria", "initials": "M"}, {"family": "Khalaf", "given": "Atika", "initials": "A"}, {"family": "Jaafar", "given": "Sabah Abdullah", "initials": "SA"}, {"family": "Kadhim", "given": "Taisir A", "initials": "TA"}, {"family": "Hweissa", "given": "Nada Ab", "initials": "NA"}, {"family": "Teng", "given": "Yulong", "initials": "Y"}, {"family": "Mohammed", "given": "Fatima E", "initials": "FE"}, {"family": "Sasikumar", "given": "Thayahlini", "initials": "T"}, {"family": "Hikaambo", "given": "Christabel Nangandu", "initials": "CN"}, {"family": "Kharat", "given": "Aditi", "initials": "A"}, {"family": "Lyamtseva", "given": "Ulyana", "initials": "U"}, {"family": "Aldeeb", "given": "Maya Arfan", "initials": "MA"}, {"family": "Pawlas", "given": "Natalia", "initials": "N"}, {"family": "Khorolsuren", "given": "Lkhagvasuren", "initials": "L"}, {"family": "Koonjul", "given": "Roopeshwaree Pallavi", "initials": "RP"}, {"family": "Ma\u00efnassara", "given": "Halima Boubacar", "initials": "HB"}, {"family": "Chahal", "given": "Priyanka", "initials": "P"}, {"family": "Wangeci", "given": "Rose W", "initials": "RW"}, {"family": "Kumar", "given": "Ainur B", "initials": "AB"}, {"family": "Zamora-Corrales", "given": "Irina", "initials": "I"}, {"family": "Gracy", "given": "Stella", "initials": "S"}, {"family": "Mahamat", "given": "Maimouna", "initials": "M"}, {"family": "Adamczyk", "given": "Jakub", "initials": "J"}, {"family": "Rahman", "given": "Haliza Abdul", "initials": "HA"}, {"family": "Matiashova", "given": "Lolita", "initials": "L"}, {"family": "Elsherif", "given": "Omneya Ezzat", "initials": "OE"}, {"family": "Alkhateeb", "given": "Nazdar E", "initials": "NE"}, {"family": "Aleaga", "given": "Yamil\u00e9", "initials": "Y"}, {"family": "Bahrami", "given": "Shima", "initials": "S"}, {"family": "Al-Salihy", "given": "Shaimaa Rahem", "initials": "SR"}, {"family": "Cabrera-Galeana", "given": "Paula", "initials": "P"}, {"family": "Lalic-Popovic", "given": "Mladena", "initials": "M"}, {"family": "Brown-Myrie", "given": "Eugenie", "initials": "E"}, {"family": "Bhandari", "given": "Divya", "initials": "D"}, {"family": "Mayaboti", "given": "Cinderella Akbar", "initials": "CA"}, {"family": "Stani\u0161i\u0107", "given": "Svetlana", "initials": "S"}, {"family": "Pestic", "given": "Sanda Kreitmayer", "initials": "SK"}, {"family": "Bektay", "given": "Muhammed Yunus", "initials": "MY"}, {"family": "Al Sabbah", "given": "Haleama", "initials": "H"}, {"family": "Hashemi", "given": "Saber", "initials": "S"}, {"family": "Assia", "given": "Bouchetara", "initials": "B"}, {"family": "Merritt", "given": "Anne-Sophie", "initials": "A"}, {"family": "Ramzi", "given": "Zhian", "initials": "Z"}, {"family": "Baboolal", "given": "Himawatee", "initials": "H"}, {"family": "Isstaif", "given": "Juman", "initials": "J"}, {"family": "Shami", "given": "Rula", "initials": "R"}, {"family": "Saad", "given": "Rahma", "initials": "R"}, {"family": "Nyirongo", "given": "Temwanani", "initials": "T"}, {"family": "Hoseini", "given": "Mohammad", "initials": "M", "orcid": "0000-0001-5180-3047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88d9726fdadb43758c8e8e5d941b1267.json"}}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Environ Sci Pollut Res Int", "issn": "1614-7499", "issn-l": null, "volume": "30", "issue": "28", "pages": "72368-72388"}, "abstract": "COVID-19 has affected all aspects of human life so far. From the outset of the pandemic, preventing the spread of COVID-19 through the observance of health protocols, especially the use of sanitizers and disinfectants was given more attention. Despite the effectiveness of disinfection chemicals in controlling and preventing COVID-19, there are critical concerns about their adverse effects on human health. This study aims to assess the health effects of sanitizers and disinfectants on a global scale. A total of 91,056 participants from 154 countries participated in this cross-sectional study. Information on the use of sanitizers and disinfectants and health was collected using an electronic questionnaire, which was translated into 26 languages via web-based platforms. The findings of this study suggest that detergents, alcohol-based substances, and chlorinated compounds emerged as the most prevalent chemical agents compared to other sanitizers and disinfectants examined. Most frequently reported health issues include skin effects and respiratory effects. The Chi-square test showed a significant association between chlorinated compounds (sodium hypochlorite and per-chlorine) with all possible health effects under investigation (p-value <0.001). Examination of risk factors based on multivariate logistic regression analysis showed that alcohols and alcohols-based materials were associated with skin effects (OR, 1.98; 95%CI, 1.87-2.09), per-chlorine was associated with eye effects (OR, 1.83; 95%CI, 1.74-1.93), and highly likely with itching and throat irritation (OR, 2.00; 95%CI, 1.90-2.11). Furthermore, formaldehyde was associated with a higher prevalence of neurological effects (OR, 2.17; 95%CI, 1.92-2.44). Furthermore, formaldehyde was associated with a higher prevalence of neurological effects (OR, 2.17; 95%CI, 1.92-2.44). The use of sodium hypochlorite and per-chlorine also had a high chance of having respiratory effects. The findings of the current study suggest that health authorities need to implement more awareness programs about the side effects of using sanitizers and disinfectants during viral epidemics especially when they are used or overused.", "doi": "10.1007/s11356-023-27197-6", "pmid": "37166731", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10173232"}, {"db": "pii", "key": "10.1007/s11356-023-27197-6"}], "notes": [], "created": "2023-10-04T05:12:04.405Z", "modified": "2023-10-04T07:27:53.594Z"}, {"entity": "publication", "iuid": "8d005afcbfa84b5d896a0c02be7a01e0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d005afcbfa84b5d896a0c02be7a01e0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d005afcbfa84b5d896a0c02be7a01e0"}}, "title": "Changes in lifestyle, adiposity, and cardiometabolic markers among young adults in Sweden during the COVID-19 pandemic.", "authors": [{"family": "Ekstr\u00f6m", "given": "Sandra", "initials": "S"}, {"family": "Andersson", "given": "Niklas", "initials": "N"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "Georgelis", "given": "Antonios", "initials": "A"}, {"family": "Ljungman", "given": "Petter L S", "initials": "PLS"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Bergstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2023-05-31", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "23", "issue": "1", "pages": "1026"}, "abstract": "The COVID-19 pandemic has impacted on public health in several ways. The aim of the study was to investigate changes in lifestyle, adiposity, and cardiometabolic markers among young adults in Sweden during the COVID-19 pandemic and their determinants.\r\n\r\nThe study included 1 004 participants from the population-based birth cohort BAMSE. Anthropometrics, body composition (bioelectric impedance analyses), pulse, and blood pressure were measured before (December 2016-May 2019; mean age 22.6 years) and during (October 2020-June 2021; mean age 25.7 years) the COVID-19 pandemic. Lifestyle changes during the pandemic were assessed through a questionnaire.\r\n\r\nAll measures of adiposity (weight, BMI, body fat percentage, trunk fat percentage) and cardiometabolic markers (blood pressure, pulse) increased during the study period (e.g., body fat percentage by a median of + 0.8% in females, p < 0.001, and + 1.5% in males, p < 0.001). Male sex, non-Scandinavian ethnicity, BMI status (underweight and obesity), and changes in lifestyle factors, e.g., decreased physical activity during the pandemic, were associated with higher increase in BMI and/or adiposity.\r\n\r\nLifestyle factors, adiposity and cardiometabolic markers may have been adversely affected among young adults in Sweden during the COVID-19 pandemic compared with the preceding years. Targeted public health measures to reduce obesity and improve healthy lifestyle are important to prevent future non-communicable diseases.", "doi": "10.1186/s12889-023-15998-w", "pmid": "37259040", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Funder: VR": null, "Funder: Forte": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10230124"}, {"db": "pii", "key": "10.1186/s12889-023-15998-w"}], "notes": [], "created": "2023-10-04T09:30:58.793Z", "modified": "2023-10-04T10:39:32.251Z"}, {"entity": "publication", "iuid": "d68c8a168fc6476b970f546ee7eed474", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d68c8a168fc6476b970f546ee7eed474.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d68c8a168fc6476b970f546ee7eed474"}}, "title": "Reduced Binding between Omicron B.1.1.529 and the Human ACE2 Receptor in a Surrogate Virus Neutralization Test for SARS-CoV-2.", "authors": [{"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Kolstad", "given": "Linda", "initials": "L"}, {"family": "Akaberi", "given": "Dario", "initials": "D"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD", "orcid": "0000-0002-7075-1059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4c50079915c44d39c996741c6156bfa.json"}}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B", "orcid": "0000-0003-0229-093X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ffe383004ef44bc6b7639ce49e8f4295.json"}}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5", "orcid": "0000-0001-8608-6551", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d8e20ea891e4e038dddde238aa79627.json"}}], "type": "journal article", "published": "2023-05-30", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "15", "issue": "6", "pages": null}, "abstract": "The current gold standard assay for detecting neutralizing antibodies (NAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the conventional virus neutralization test (cVNT), which requires infectious virus and a biosafety level 3 laboratory. Here, we report the development of a SARS-CoV-2 surrogate virus neutralization test (sVNT) that, with Luminex technology, detects NAbs. The assay was designed to mimic the virus-host interaction and is based on antibody blockage between the human angiotensin-converting enzyme 2 (hACE2) receptor and the spike (S) protein of the Wuhan, Delta, and Omicron (B.1.1.529) variants of SARS-CoV-2. The sVNT proved to have a 100% correlation with a SARS-CoV-2 cVNT regarding qualitative results. Binding between the hACE2 receptor and the S1 domain of the B.1.1.529 lineage of the Omicron variant was not observed in the assay but between the receptor and an S1 + S2 trimer and the receptor binding domain (RBD) in a reduced manner, suggesting less efficient receptor binding for the B.1.1.529 Omicron variant. The results indicate that the SARS-CoV-2 sVNT is a suitable tool for both the research community and the public health service, as it may serve as an efficient diagnostic alternative to the cVNT.", "doi": "10.3390/v15061280", "pmid": "37376580", "labels": {"Category: Proteins": null, "Funder: VR": null, "Category: Serology": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC10301322"}, {"db": "pii", "key": "v15061280"}], "notes": [], "created": "2023-10-04T09:31:46.194Z", "modified": "2023-10-04T10:54:03.277Z"}, {"entity": "publication", "iuid": "de3655e5b5104cc0a72eb07b0ea09364", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/de3655e5b5104cc0a72eb07b0ea09364.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/de3655e5b5104cc0a72eb07b0ea09364"}}, "title": "Intensive care nurses' experiences of caring for patients during the COVID-19 pandemic based on an analysis of blog posts.", "authors": [{"family": "Skoglund", "given": "Karin", "initials": "K", "orcid": "0000-0001-8008-8169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e6fc2925ce9443e865e3dc39411af54.json"}}, {"family": "\u00c5hlman", "given": "Ebba", "initials": "E"}, {"family": "Mallin", "given": "Sofia", "initials": "S"}, {"family": "Holmgren", "given": "Jessica", "initials": "J", "orcid": "0000-0002-8551-3264", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a97a6a6656dc41f8ac7aad2547261322.json"}}], "type": "journal article", "published": "2023-05-30", "journal": {"title": "Nurs Crit Care", "issn": "1478-5153", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "In 2019, coronavirus disease 2019 (COVID-19) broke out worldwide, leading to a pandemic. Studies have shown that COVID-19 patients in intensive care units (ICUs) require more nursing care than other patients. ICU nurses who care for patients with COVID-19 have shown signs of psychological and physical strain.\r\n\r\nThe aim of this study was to illuminate ICU nurses' experiences of caring for patients with COVID-19 in ICUs during the first wave of the pandemic.\r\n\r\nA qualitative, descriptive and inductive approach was used.\r\n\r\nA total of 70 blog posts from 13 bloggers in the United States, Great Britain, Finland and Sweden were analysed using qualitative inductive manifest content analysis.\r\n\r\nThe results reveal an overall theme: 'An overturned existence under extreme conditions'. Furthermore, three categories-'the virus caused changes in work and private lives', 'unreasonable demands', and to hold on to caring ideals thanks to the support of others'-and seven subcategories were identified.\r\n\r\nCaring for patients with COVID-19 during the first wave of the pandemic was demanding because of a lack of knowledge about the disease and the severity of the illness. This led to ICU nurses experiencing extreme conditions that affected various aspects of their lives. Support from colleagues and teamwork were revealed to be particularly important for how nurses dealt with the demands of working during a pandemic, as was sufficient recovery time between work shifts.\r\n\r\nWork in ICUs was challenging and demanding, even before the pandemic. This study contributes to an understanding of the complex work environment that existed in hospitals during the first wave of the COVID-19 pandemic. The knowledge obtained from this study can be used to revise working conditions and identify health interventions for ICU nurses.", "doi": "10.1111/nicc.12931", "pmid": "37248953", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:09:43.513Z", "modified": "2023-10-04T06:07:09.604Z"}, {"entity": "publication", "iuid": "01ff4dc2353e4b8e8cb12a0ca6ed29a3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01ff4dc2353e4b8e8cb12a0ca6ed29a3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01ff4dc2353e4b8e8cb12a0ca6ed29a3"}}, "title": "The impact of the COVID-19 pandemic on adverse fetal outcomes: A cross-sectional study", "authors": [{"family": "Dageli\u0107", "given": "Andrea", "initials": "A", "orcid": "0000-0001-9374-652X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c003b74a9039488c988a6217611179d5.json"}}, {"family": "Mulic", "given": "Emma", "initials": "E"}, {"family": "Kuzmic Prusac", "given": "Ivana", "initials": "I"}, {"family": "Zekic Tomas", "given": "Sandra", "initials": "S"}], "type": "journal-article", "published": "2023-05-26", "journal": {"title": null, "issn": "0025-7974", "issn-l": null, "volume": "102", "issue": "21", "pages": "e33887"}, "abstract": null, "doi": "10.1097/md.0000000000033887", "pmid": null, "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:10:52.794Z", "modified": "2023-10-04T07:01:12.953Z"}, {"entity": "publication", "iuid": "7b561974f87c49d5ae37c5b8d9642013", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b561974f87c49d5ae37c5b8d9642013.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b561974f87c49d5ae37c5b8d9642013"}}, "title": "Nucleocapsid-specific T cell responses associate with control of SARS-CoV-2 in the upper airways before seroconversion.", "authors": [{"family": "Eser", "given": "Tabea M", "initials": "TM"}, {"family": "Baranov", "given": "Olga", "initials": "O"}, {"family": "Huth", "given": "Manuel", "initials": "M"}, {"family": "Ahmed", "given": "Mohammed I M", "initials": "MIM"}, {"family": "De\u00e1k", "given": "Flora", "initials": "F"}, {"family": "Held", "given": "Kathrin", "initials": "K", "orcid": "0000-0001-7057-6935", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f231ea9496f44e7583759b1bfb4ebdc1.json"}}, {"family": "Lin", "given": "Luming", "initials": "L"}, {"family": "Pekayvaz", "given": "Kami", "initials": "K", "orcid": "0000-0003-4040-650X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4eca6461e96449888f127c3fdb1c32ea.json"}}, {"family": "Leunig", "given": "Alexander", "initials": "A", "orcid": "0000-0002-9179-9203", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a485b7ea41942dc93c9b97f7606a207.json"}}, {"family": "Nicolai", "given": "Leo", "initials": "L", "orcid": "0000-0003-0776-5885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea251a7bafc44037b1e396bc701ee5ec.json"}}, {"family": "Pollakis", "given": "Georgios", "initials": "G", "orcid": "0000-0002-9659-5461", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e3c57acb0fe344d2b70287bf40755970.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}, {"family": "Price", "given": "David A", "initials": "DA", "orcid": "0000-0001-9416-2737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/734b7fd55fca47f8b00d1281331ef39a.json"}}, {"family": "Rubio-Acero", "given": "Raquel", "initials": "R"}, {"family": "Reich", "given": "Jakob", "initials": "J"}, {"family": "Falk", "given": "Philine", "initials": "P"}, {"family": "Markgraf", "given": "Alissa", "initials": "A"}, {"family": "Puchinger", "given": "Kerstin", "initials": "K"}, {"family": "Castelletti", "given": "Noemi", "initials": "N"}, {"family": "Olbrich", "given": "Laura", "initials": "L"}, {"family": "Vanshylla", "given": "Kanika", "initials": "K"}, {"family": "Klein", "given": "Florian", "initials": "F", "orcid": "0000-0003-1376-1792", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc5736c1f6d84545aedc698ba8923b72.json"}}, {"family": "Wieser", "given": "Andreas", "initials": "A"}, {"family": "Hasenauer", "given": "Jan", "initials": "J", "orcid": "0000-0002-4935-3312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e7be5dc819640ff93da1f6e76ef6998.json"}}, {"family": "Kroidl", "given": "Inge", "initials": "I"}, {"family": "Hoelscher", "given": "Michael", "initials": "M"}, {"family": "Geldmacher", "given": "Christof", "initials": "C"}], "type": "journal article", "published": "2023-05-24", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "14", "issue": "1", "pages": "2952"}, "abstract": "Despite intensive research since the emergence of SARS-CoV-2, it has remained unclear precisely which components of the early immune response protect against the development of severe COVID-19. Here, we perform a comprehensive immunogenetic and virologic analysis of nasopharyngeal and peripheral blood samples obtained during the acute phase of infection with SARS-CoV-2. We find that soluble and transcriptional markers of systemic inflammation peak during the first week after symptom onset and correlate directly with upper airways viral loads (UA-VLs), whereas the contemporaneous frequencies of circulating viral nucleocapsid (NC)-specific CD4+ and CD8+ T cells correlate inversely with various inflammatory markers and UA-VLs. In addition, we show that high frequencies of activated CD4+ and CD8+ T cells are present in acutely infected nasopharyngeal tissue, many of which express genes encoding various effector molecules, such as cytotoxic proteins and IFN-\u03b3. The presence of IFNG mRNA-expressing CD4+ and CD8+ T cells in the infected epithelium is further linked with common patterns of gene expression among virus-susceptible target cells and better local control of SARS-CoV-2. Collectively, these results identify an immune correlate of protection against SARS-CoV-2, which could inform the development of more effective vaccines to combat the acute and chronic illnesses attributable to COVID-19.", "doi": "10.1038/s41467-023-38020-8", "pmid": "37225706", "labels": {"Category: Proteins": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10209201"}, {"db": "pii", "key": "10.1038/s41467-023-38020-8"}], "notes": [], "created": "2023-10-04T05:08:42.239Z", "modified": "2023-10-04T05:19:11.862Z"}, {"entity": "publication", "iuid": "74d814ab0f594337b2c3250af3cb3500", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/74d814ab0f594337b2c3250af3cb3500.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/74d814ab0f594337b2c3250af3cb3500"}}, "title": "Association between SARS-CoV-2 infection and newly diagnosed hypertension during pregnancy: prospective, population based cohort study.", "authors": [{"family": "\u00d6rtqvist", "given": "Anne K", "initials": "AK", "orcid": "0000-0001-9019-9233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7bfdbeb2a2d848ec928a6c7f7d112465.json"}}, {"family": "Magnus", "given": "Maria C", "initials": "MC"}, {"family": "Dahlqvist", "given": "Elisabeth", "initials": "E"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Johansson", "given": "Kari", "initials": "K", "orcid": "0000-0002-1497-3079", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f592ab7cb9645098896efc10bee41c4.json"}}, {"family": "Sandstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}, {"family": "Stephansson", "given": "Olof", "initials": "O", "orcid": "0000-0003-1528-4563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39af50356a574c80ba6bd2227ecb5cf5.json"}}], "type": "journal article", "published": "2023-05-24", "journal": {"title": "BMJ Med", "issn": "2754-0413", "issn-l": null, "volume": "2", "issue": "1", "pages": "e000465"}, "abstract": "To study the association between SARS-CoV-2 infection and newly diagnosed hypertension during pregnancy.\r\n\r\nProspective, population based cohort study.\r\n\r\nAll singleton pregnancies after 22 completed gestational weeks registered in the Swedish Pregnancy Register and the Medical Birth Registry of Norway, from 1 March 2020 to 24 May 2022.\r\n\r\n312 456 individuals available for analysis (201 770 in Sweden and 110 686 in Norway), with pregnancies that reached 42 completed gestational weeks by the end of follow-up in the pregnancy registries, excluding individuals with SARS-CoV-2 infection before pregnancy and those with a diagnosis of pre-existing hypertension or onset of hypertension before 20 gestational weeks.\r\n\r\nNewly diagnosed hypertension during pregnancy was defined as a composite outcome of a diagnosis of gestational hypertension, pre-eclampsia, HELLP (haemolysis, elevated liver enzymes, low platelets) syndrome, or eclampsia, from gestational week 20 to one week after delivery. The association between SARS-CoV-2 infection and hypertension during pregnancy was investigated with a stratified Cox proportional hazard model, adjusting for maternal age, body mass index, parity, smoking, region of birth, education, income, coexisting medical conditions, previous hypertension during pregnancy, number of healthcare visits during the past year, and vaccination against SARS-CoV-2. Pre-eclampsia was also analysed as a separate outcome.\r\n\r\nOf 312 456 individuals available for analysis, 8% (n=24 566) had SARS-CoV-2 infection any time during pregnancy, 6% (n=18 051) had a diagnosis of hypertension during pregnancy, and 3% (9899) had pre-eclampsia. SARS-CoV-2 infection during pregnancy was not associated with an increased risk of hypertension during pregnancy (adjusted hazard ratio 0.99, 95% confidence interval 0.93 to 1.04) or pre-eclampsia (0.98, 0.87 to 1.10). The results were similar for SARS-CoV-2 infection in all gestational trimesters and in different time periods that corresponded to dominance of different variants of the SARS-CoV-2 virus.\r\n\r\nThis population based study did not find any evidence of an association between SARS-CoV-2 infection during pregnancy and an increased risk of hypertension during pregnancy or pre-eclampsia.", "doi": "10.1136/bmjmed-2022-000465", "pmid": "37275554", "labels": {"Category: Health": null, "Funder: H2020": null, "Funder: NordForsk": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10230329"}, {"db": "pii", "key": "bmjmed-2022-000465"}], "notes": [], "created": "2023-10-04T09:31:57.973Z", "modified": "2023-10-04T10:59:41.792Z"}, {"entity": "publication", "iuid": "a41b6cfc55034bb69940f6ea84543eda", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a41b6cfc55034bb69940f6ea84543eda.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a41b6cfc55034bb69940f6ea84543eda"}}, "title": "Insomnia and job stressors among healthcare workers who served COVID-19 patients in Bangladesh.", "authors": [{"family": "Rahman", "given": "Farzana", "initials": "F"}, {"family": "Dalal", "given": "Koustuv", "initials": "K"}, {"family": "Hasan", "given": "Mehedi", "initials": "M"}, {"family": "Islam", "given": "Tariful", "initials": "T"}, {"family": "Tuli", "given": "Samiha Nahar", "initials": "SN"}, {"family": "Akter", "given": "Asma", "initials": "A"}, {"family": "Tanvir", "given": "K M", "initials": "KM"}, {"family": "Islam", "given": "Khairul", "initials": "K"}, {"family": "Rahman", "given": "Ashikur", "initials": "A"}, {"family": "Nabi", "given": "Mohammad Hayatun", "initials": "MH"}, {"family": "Rahman", "given": "Mohammad Lutfor", "initials": "ML"}, {"family": "Hossain Hawlader", "given": "Mohammad Delwer", "initials": "MD"}], "type": "journal article", "published": "2023-05-23", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "issn-l": null, "volume": "23", "issue": "1", "pages": "523"}, "abstract": "The global outbreak of COVID-19 has created unprecedented havoc among health care workers, resulting in significant psychological strains like insomnia. This study aimed to analyze insomnia prevalence and job stressors among Bangladeshi health care workers in COVID-19 units.\r\n\r\nWe conducted this cross-sectional study to assess insomnia severity from January to March 2021 among 454 health care workers working in multiple hospitals in Dhaka city with active COVID-dedicated units. We selected 25 hospitals conveniently. We used a structured questionnaire for face-to-face interviews containing sociodemographic variables and job stressors. The severity of insomnia was measured by the Insomnia Severity Scale (ISS). The scale has seven items to evaluate the rate of insomnia, which was categorized as the absence of Insomnia (0-7); sub-threshold Insomnia (8-14); moderate clinical Insomnia (15-21); and severe clinical Insomnia (22-28). To identify clinical insomnia, a cut-off value of 15 was decided primarily. A cut-off score of 15 was initially proposed for identifying clinical insomnia. We performed a chi-square test and adjusted logistic regression to explore the association of different independent variables with clinically significant insomnia using the software SPSS version 25.0.\r\n\r\n61.5% of our study participants were females. 44.9% were doctors, 33.9% were nurses, and 21.1% were other health care workers. Insomnia was more dominant among doctors and nurses (16.2% and 13.6%, respectively) than others (4.2%). We found clinically significant insomnia was associated with several job stressors (p < 0.05). In binary logistic regression, having sick leave (OR = 0.248, 95% CI = 0.116, 0.532) and being entitled to risk allowance (OR = 0.367, 95% CI = 0.124.1.081) showed lower odds of developing Insomnia. Previously diagnosed with COVID-19-positive health care workers had an OR of 2.596 (95% CI = 1.248, 5.399), pointing at negative experiences influencing insomnia. In addition, we observed that any training on risk and hazard increased the chances of suffering from Insomnia (OR = 1.923, 95% CI = 0.934, 3.958).\r\n\r\nIt is evident from the findings that the volatile existence and ambiguity of COVID-19 have induced significant adverse psychological effects and subsequently directed our HCWs toward disturbed sleep and insomnia. The study recommends the imperativeness to formulate and implement collaborative interventions to help HCWs cope with this crisis and mitigate the mental stresses they experience during the pandemic.", "doi": "10.1186/s12913-023-09464-x", "pmid": "37221591", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10204693"}, {"db": "pii", "key": "10.1186/s12913-023-09464-x"}], "notes": [], "created": "2023-10-04T05:10:58.106Z", "modified": "2023-10-04T07:02:39.981Z"}, {"entity": "publication", "iuid": "7e426d44c7a94201b356d6ffe6de95e6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e426d44c7a94201b356d6ffe6de95e6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e426d44c7a94201b356d6ffe6de95e6"}}, "title": "Clustering Analysis Identified Three Long COVID Phenotypes and Their Association with General Health Status and Working Ability.", "authors": [{"family": "Kisiel", "given": "Marta A", "initials": "MA"}, {"family": "Lee", "given": "Seika", "initials": "S"}, {"family": "Malmquist", "given": "Sara", "initials": "S", "orcid": "0009-0002-1404-9721", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2beb89d6d65143b1b212af06fd5315ea.json"}}, {"family": "Rykatkin", "given": "Oliver", "initials": "O"}, {"family": "Holgert", "given": "Sebastian", "initials": "S"}, {"family": "Janols", "given": "Helena", "initials": "H"}, {"family": "Janson", "given": "Christer", "initials": "C"}, {"family": "Zhou", "given": "Xingwu", "initials": "X", "orcid": "0000-0002-9831-9102", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9497b3ea54cc45be9ee3e7fe596b184c.json"}}], "type": "journal article", "published": "2023-05-23", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "12", "issue": "11", "pages": null}, "abstract": "This study aimed to distinguish different phenotypes of long COVID through the post-COVID syndrome (PCS) score based on long-term persistent symptoms following COVID-19 and evaluate whether these symptoms affect general health and work ability. In addition, the study identified predictors for severe long COVID.\r\n\r\nThis cluster analysis included cross-sectional data from three cohorts of patients after COVID-19: non-hospitalized (n = 401), hospitalized (n = 98) and those enrolled at the post-COVID outpatient's clinic (n = 85). All the subjects responded to the survey on persistent long-term symptoms and sociodemographic and clinical factors. K-Means cluster analysis and ordinal logistic regression were used to create PCS scores that were used to distinguish patients' phenotypes.\r\n\r\n506 patients with complete data on persistent symptoms were divided into three distinct phenotypes: none/mild (59%), moderate (22%) and severe (19%). The patients with severe phenotype, with the predominating symptoms were fatigue, cognitive impairment and depression, had the most reduced general health status and work ability. Smoking, snuff, body mass index (BMI), diabetes, chronic pain and symptom severity at COVID-19 onset were factors predicting severe phenotype.\r\n\r\nThis study suggested three phenotypes of long COVID, where the most severe was associated with the highest impact on general health status and working ability. This knowledge on long COVID phenotypes could be used by clinicians to support their medical decisions regarding prioritizing and more detailed follow-up of some patient groups.", "doi": "10.3390/jcm12113617", "pmid": "37297812", "labels": {"Category: Social Science & Humanities": null, "Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10253616"}, {"db": "pii", "key": "jcm12113617"}], "notes": [], "created": "2023-10-04T09:31:36.523Z", "modified": "2023-10-04T10:50:11.813Z"}, {"entity": "publication", "iuid": "8c1fa59dc74846e69add24cb8640bd11", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c1fa59dc74846e69add24cb8640bd11.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c1fa59dc74846e69add24cb8640bd11"}}, "title": "The risk for celiac disease after Covid-19 infection.", "authors": [{"family": "Lexner", "given": "Jesper", "initials": "J"}, {"family": "Lindroth", "given": "Ylva", "initials": "Y"}, {"family": "Sj\u00f6berg", "given": "Klas", "initials": "K"}], "type": "journal article", "published": "2023-05-22", "journal": {"title": "BMC Gastroenterol", "issn": "1471-230X", "issn-l": null, "volume": "23", "issue": "1", "pages": "174"}, "abstract": "Celiac disease (CD) is an autoimmune disease leading to gastrointestinal symptoms and mineral deficiencies. The pathogenetic mechanisms, besides the clear HLA association, are elusive. Among environmental factors infections have been proposed. Covid-19 infection results in a systemic inflammatory response that often also involves the gastrointestinal tract. The aim of the present study was to investigate whether Covid-19 infection could increase the risk for CD.\r\n\r\nAll patients, both children and adults, in the county Sk\u00e5ne (1.4 million citizens) in southern Sweden with newly diagnosed biopsy- or serology-verified CD or a positive tissue transglutaminase antibody test (tTG-ab) during 2016-2021 were identified from registries at the Departments of Pathology and Immunology, respectively. Patients with a positive Covid-19 PCR or antigen test in 2020 and 2021 were identified from the Public Health Agency of Sweden.\r\n\r\nDuring the Covid-19 pandemic (March 2020 - December 2021), there were 201 050 cases of Covid-19 and 568 patients with biopsy- or serology-verified CD or a first-time positive tTG-ab tests, of which 35 patients had been infected with Covid-19 before CD. The incidence of verified CD and tTG-ab positivity was lower in comparison to before the pandemic (May 2018 - February 2020; 22.5 vs. 25.5 cases per 100 000 person-years, respectively, incidence rate difference (IRD) -3.0, 95% CI -5.7 - -0.3, p = 0.028). The incidence of verified CD and tTG-ab positivity in patients with and without prior Covid-19 infection was 21.1 and 22.4 cases per 100 000 person-years, respectively (IRD - 1.3, 95% CI -8.5-5.9, p = 0.75).\r\n\r\nOur results indicate that Covid-19 is not a risk factor for CD development. While gastrointestinal infections seem to be an important part of the CD pathogenesis, respiratory infections probably are of less relevance.", "doi": "10.1186/s12876-023-02795-3", "pmid": "37217874", "labels": {"Category: Serology": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10202072"}, {"db": "pii", "key": "10.1186/s12876-023-02795-3"}], "notes": [], "created": "2023-10-04T05:09:38.514Z", "modified": "2023-10-04T06:04:13.447Z"}, {"entity": "publication", "iuid": "f755a5acb7b34b63ad7d93b44e2f29eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f755a5acb7b34b63ad7d93b44e2f29eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f755a5acb7b34b63ad7d93b44e2f29eb"}}, "title": "Serum IL-23, IL-10, and TNF-\u03b1 predict in-hospital mortality in COVID-19 patients.", "authors": [{"family": "Smail", "given": "Shukur Wasman", "initials": "SW"}, {"family": "Babaei", "given": "Esmaeil", "initials": "E"}, {"family": "Amin", "given": "Kawa", "initials": "K"}, {"family": "Abdulahad", "given": "Wayel H", "initials": "WH"}], "type": "journal article", "published": "2023-05-22", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "1145840"}, "abstract": "The hyperinflammatory response, caused by severe acute respiratory syndrome-2 (SARS-CoV-2), is the most common cause of death in patients with coronavirus disease 2019 (COVID-19). The etiopathogenesis of this illness is not fully understood. Macrophages appear to play a key part in COVID-19's pathogenic effects. Therefore, this study aims to examine serum inflammatory cytokines associated with the activation state of macrophages in COVID-19 patients and attempt to find accurate predictive markers for disease severity and mortality risk in hospital.\r\n\r\n180 patients with COVID-19 and 90 healthy controls (HCs) participated in this study. Patients were divided into three different subgroups, mild (n=81), severe (n=60), and critical groups (n=39). Serum samples were collected and IL (Interleukin)-10, IL-23, tumor necrosis factor-alpha (TNF-\u03b1), interferon-gamma (IFN-\u03b3), IL-17, monocyte chemoattractant protein-1 (MCP-1) and chemokine ligand 3 (CCL3) were determined by ELISA. In parallel, myeloperoxidase (MPO) and C-reactive protein (CRP) were measured using colorimetric and electrochemiluminescence methods, respectively. Data were collected, and their associations with disease progression and mortality were assessed using regression models and receiver operating characteristic (ROC) curves.\r\n\r\nCompared to HCs, a significant increase in IL-23, IL-10, TNF-\u03b1, IFN-\u03b3 and MCP-1, were observed in COVID-19 patients. Serum levels of IL-23, IL-10, and TNF-\u03b1 were significantly higher in COVID-19 patients with critical cases compared to mild and severe cases, and correlated positively with CRP level. However, non-significant changes were found in serum MPO and CCL3 among the studied groups. Moreover, significant positive association has been observed among increased IL-10, IL-23 and TNF-\u03b1 in serum of COVID-19 patients. Furthermore, a binary logistic regression model was applied to predict death's independent factors. Results showed that IL-10 alone or in combination with IL23 and TNF-\u03b1 are strongly linked with non-survivors in COVID-19 patients. Finally, ROC curve results uncovered that IL-10, IL-23 and TNF-\u03b1 were excellent predictors for prognosing COVID-19.\r\n\r\nThe elevations of IL-10, IL-23, and TNF-\u03b1 levels were seen in severe and critical cases of COVID-19 patients and their elevations were linked to the in-hospital mortality of the disease. A prediction model shows that the determination of these cytokines upon admission is important and should be done on COVID-19 patients as a way of evaluating the prognosis of the disease. COVID-19 Patients with high IL-10, IL-23, and TNF-\u03b1 on admission are more likely to experience a severe form of the disease; therefore, those patients should be cautionary monitored and treated.", "doi": "10.3389/fimmu.2023.1145840", "pmid": "37283736", "labels": {"Category: Biochemistry": null, "Category: Serology": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10239952"}], "notes": [], "created": "2023-10-04T09:30:09.738Z", "modified": "2023-10-04T09:50:07.803Z"}, {"entity": "publication", "iuid": "e84173f451f64b809dc0a626971777c8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e84173f451f64b809dc0a626971777c8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e84173f451f64b809dc0a626971777c8"}}, "title": "Staff quality of working life and turnover intentions in municipal nursing care and social welfare: a cross-sectional study.", "authors": [{"family": "Engstr\u00f6m", "given": "Maria", "initials": "M", "orcid": "0000-0002-9912-5350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5497902ecdbb4df0a2678becfdb2678b.json"}}, {"family": "Jarnheden", "given": "Sofia Hanberger", "initials": "SH", "orcid": "0000-0003-4864-2400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/802cfff423144af39472f93e1dd5af5f.json"}}, {"family": "Tham", "given": "Pia", "initials": "P", "orcid": "0000-0003-4155-810X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8544cc6baab44c1c8a8d4fc86653c70f.json"}}], "type": "journal article", "published": "2023-05-19", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "issn-l": null, "volume": "22", "issue": "1", "pages": "171"}, "abstract": "Nurses and social workers are two common professions with a university degree working within municipal nursing care and social welfare. Both groups have high turnover intention rates, and there is a need to better understand their quality of working life and turnover intentions in general and more specifically during the Covid-19 pandemic. This study investigated associations between working life, coping strategies and turnover intentions of staff with a university degree working within municipal care and social welfare during the Covid-19 pandemic.\r\n\r\nA cross-sectional design; 207 staff completed questionnaires and data were analyzed using multiple linear regression analyses.\r\n\r\nTurnover intentions were common. For registered nurses 23% thought of leaving the workplace and 14% the profession 'rather often' and 'very often/always'. The corresponding figures for social workers were 22% (workplace) and 22% (profession). Working life variables explained 34-36% of the variance in turnover intentions. Significant variables in the multiple linear regression models were work-related stress, home-work interface and job-career satisfaction (both for the outcome turnover intentions profession and workplace) and Covid-19 exposure/patients (turnover intentions profession). For the chosen coping strategies, 'exercise', 'recreation and relaxation' and 'improving skills', the results (associations with turnover) were non-significant. However, comparing the groups social workers reported that they used 'recreation and relaxation' more often than were reported by registered nurses.\r\n\r\nMore work-related stress, worse home-work interface and less job-career satisfaction together with Covid-19 exposure/patients (Covid-19 only for turnover profession) increase turnover intentions. Recommendations are that managers should strive for better home-work interface and job-career satisfaction, monitor and counteract work-related stress to prevent turnover intentions.", "doi": "10.1186/s12912-023-01339-0", "pmid": "37202759", "labels": {"Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10195664"}, {"db": "pii", "key": "10.1186/s12912-023-01339-0"}], "notes": [], "created": "2023-10-04T05:09:54.134Z", "modified": "2023-10-04T06:22:41.430Z"}, {"entity": "publication", "iuid": "3f935702fdea4236995c2f3e832343d1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f935702fdea4236995c2f3e832343d1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f935702fdea4236995c2f3e832343d1"}}, "title": "Detoxified synthetic bacterial membrane vesicles as a vaccine platform against bacteria and SARS-CoV-2.", "authors": [{"family": "Park", "given": "Kyong-Su", "initials": "K"}, {"family": "Svennerholm", "given": "Kristina", "initials": "K"}, {"family": "Crescitelli", "given": "Rossella", "initials": "R"}, {"family": "L\u00e4sser", "given": "Cecilia", "initials": "C"}, {"family": "Gribonika", "given": "Inta", "initials": "I"}, {"family": "Andersson", "given": "Mickael", "initials": "M"}, {"family": "Bostr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Alalam", "given": "Hanna", "initials": "H"}, {"family": "Harandi", "given": "Ali M", "initials": "AM"}, {"family": "Farewell", "given": "Anne", "initials": "A"}, {"family": "L\u00f6tvall", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2023-05-19", "journal": {"title": "J Nanobiotechnology", "issn": "1477-3155", "issn-l": null, "volume": "21", "issue": "1", "pages": "156"}, "abstract": "The development of vaccines based on outer membrane vesicles (OMV) that naturally bud off from bacteria is an evolving field in infectious diseases. However, the inherent inflammatory nature of OMV limits their use as human vaccines. This study employed an engineered vesicle technology to develop synthetic bacterial vesicles (SyBV) that activate the immune system without the severe immunotoxicity of OMV. SyBV were generated from bacterial membranes through treatment with detergent and ionic stress. SyBV induced less inflammatory responses in macrophages and in mice compared to natural OMV. Immunization with SyBV or OMV induced comparable antigen-specific adaptive immunity. Specifically, immunization with Pseudomonas aeruginosa-derived SyBV protected mice against bacterial challenge, and this was accompanied by significant reduction in lung cell infiltration and inflammatory cytokines. Further, immunization with Escherichia coli-derived SyBV protected mice against E. coli sepsis, comparable to OMV-immunized group. The protective activity of SyBV was driven by the stimulation of B-cell and T-cell immunity. Also, SyBV were engineered to display the SARS-CoV-2 S1 protein on their surface, and these vesicles induced specific S1 protein antibody and T-cell responses. Collectively, these results demonstrate that SyBV may be a safe and efficient vaccine platform for the prevention of bacterial and viral infections.", "doi": "10.1186/s12951-023-01928-w", "pmid": "37208676", "labels": {"Funder: VR": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10196325"}, {"db": "pii", "key": "10.1186/s12951-023-01928-w"}], "notes": [], "created": "2023-10-04T05:12:11.703Z", "modified": "2023-10-04T08:12:16.374Z"}, {"entity": "publication", "iuid": "cdcd3ca0f01044869cd89862392e5e88", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cdcd3ca0f01044869cd89862392e5e88.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cdcd3ca0f01044869cd89862392e5e88"}}, "title": "Working conditions for healthcare workers at a Swedish university hospital infectious disease department during the COVID-19 pandemic: barriers and facilitators to maintaining employee wellbeing.", "authors": [{"family": "Veje", "given": "Malin", "initials": "M"}, {"family": "Linden", "given": "Karolina", "initials": "K"}, {"family": "Sengpiel", "given": "Verena", "initials": "V"}, {"family": "Carlsson", "given": "Ylva", "initials": "Y"}, {"family": "Jonsdottir", "given": "Ingibj\u00f6rg H", "initials": "IH"}, {"family": "Degl'Innocenti", "given": "Alessio", "initials": "A"}, {"family": "Ahlstrom", "given": "Linda", "initials": "L"}, {"family": "Wijk", "given": "Helle", "initials": "H"}, {"family": "Akerstrom", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2023-05-18", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "14", "issue": null, "pages": "1183084"}, "abstract": "Healthcare workers (HCWs) at infectious disease departments have held the frontline during the COVID-19 pandemic. This study aimed to identify barriers and facilitators to maintaining the employees' wellbeing that may be used to increase preparedness for future pandemics within ID Departments.\r\n\r\nIn September 2020, a web-based survey on demographics and work environment was distributed to all HCWs at the Infectious Disease Department at Sahlgrenska University Hospital. Results were compared with a pre-COVID-19 survey from October 2019. A quantitative analysis of the overall effects of the pandemic on the working conditions of HCWs was conducted; in addition, a qualitative content analysis of open-ended responses was performed.\r\n\r\nIn total, 222 and 149 HCWs completed the pre-COVID-19 and COVID-19 surveys (84 and 54% response rate), respectively. Overall, we found significant changes regarding increased workload, lack of emotional support in stressful work situations, and inability to recover after shifts. These factors correlated both with younger age and concern of becoming infected. The open-ended answers (n = 103, 69%) revealed five generic categories (Workload; Organizational support; Worry and ethical stress; Capability; and Cooperation and unity) with a total of 14 identified factors representing plausible individual and organizational-level barriers or facilitators to sustained employee wellbeing.\r\n\r\nYounger HCWs as well as those expressing worries about contracting the infection were found to be particularly affected during the COVID-19 pandemic and these groups may require additional support in future outbreaks. Factors both increasing and decreasing the pandemic-induced negative health consequences for HCWs were identified; this knowledge may be utilized in the future.", "doi": "10.3389/fpsyg.2023.1183084", "pmid": "37275708", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10233109"}], "notes": [], "created": "2023-10-04T09:31:06.907Z", "modified": "2023-10-04T10:43:01.107Z"}, {"entity": "publication", "iuid": "10db20243623418cb19d0d22385e71b6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/10db20243623418cb19d0d22385e71b6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/10db20243623418cb19d0d22385e71b6"}}, "title": "Vision impairment is common in non-hospitalised patients with post-COVID-19 syndrome.", "authors": [{"family": "Johansson", "given": "Jan", "initials": "J", "orcid": "0000-0002-1093-4179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92589deccb094908acfe20279eab5462.json"}}, {"family": "M\u00f6ller", "given": "Marika", "initials": "M", "orcid": "0000-0001-8700-5186", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cddc264c52e1464ea162c7d9146f9021.json"}}, {"family": "Markovic", "given": "Gabriela", "initials": "G", "orcid": "0000-0002-7500-9531", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e9609af7155478eb2c7cd90694c648e.json"}}, {"family": "Borg", "given": "Kristian", "initials": "K", "orcid": "0000-0001-8748-1772", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c78e26fb1a414c69834b7261e2f93dad.json"}}], "type": "journal article", "published": "2023-05-18", "journal": {"title": "Clin Exp Optom", "issn": "1444-0938", "issn-l": null, "volume": null, "issue": null, "pages": "1-8"}, "abstract": "Vision-related problems can be part of longstanding sequelae after COVID-19 and hamper the return to work and daily activities. Knowledge about symptoms, visual, and oculomotor dysfunctions is however scarce, particularly for non-hospitalised patients. Clinically applicable tools are needed as support in the assessment and determination of intervention needs.\r\n\r\nThe purpose of this study was to evaluate vision-related symptoms, assess visual and oculomotor function, and to test the clinical assessment of saccadic eye movements and sensitivity to visual motion in non-hospitalised post-COVID-19 outpatients. The patients (n = 38) in this observational cohort study were recruited from a post-COVID-19 clinic and had been referred for neurocognitive assessment.\r\n\r\nPatients who reported vision-related symptoms reading problems and intolerance to movement in the environment were examined. A structured symptom assessment and a comprehensive vision examination were undertaken, and saccadic eye movements and visual motion sensitivity were assessed.\r\n\r\nHigh symptom scores (26-60%) and prevalence of visual function impairments were observed. An increased symptom score when reading was associated with less efficient saccadic eye movement behaviour (p < 0.001) and binocular dysfunction (p = 0.029). Patients with severe symptoms in visually busy places scored significantly higher on the Visual Motion Sensitivity Clinical Test Protocol (p = 0.029).\r\n\r\nVision-related symptoms and impairments were prevalent in the study group. The Developmental Eye Movement Test and the Visual Motion Sensitivity Clinical Test Protocol showed promise for clinical assessment of saccadic performance and sensitivity to movement in the environment. Further study will be required to explore the utility of these tools.", "doi": "10.1080/08164622.2023.2213826", "pmid": "37201931", "labels": {"Category: Social Science & Humanities": null, "Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:10:45.543Z", "modified": "2023-10-04T06:57:42.564Z"}, {"entity": "publication", "iuid": "1ef0f962c9724dd284a6914a33072c9a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ef0f962c9724dd284a6914a33072c9a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ef0f962c9724dd284a6914a33072c9a"}}, "title": "Long COVID is primarily a Spike protein Induced Thrombotic Vasculitis", "authors": [{"family": "Kerr", "given": "Robin", "initials": "R", "orcid": "0000-0003-2480-2748", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72bb5381b3d84c7fa0de3fee9efbef73.json"}}, {"family": "Carroll", "given": "Harriet A", "initials": "HA", "orcid": "0000-0002-4998-4675", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/851010212d214d9091381760df4427e4.json"}}], "type": "posted-content", "published": "2023-05-18", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.21203/rs.3.rs-2939263/v1", "pmid": null, "labels": {"Category: Post-COVID": null, "Category: Proteins": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:08:39.096Z", "modified": "2023-10-04T05:17:34.352Z"}, {"entity": "publication", "iuid": "c2a2de1360d04408925c33cdb37d5443", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2a2de1360d04408925c33cdb37d5443.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2a2de1360d04408925c33cdb37d5443"}}, "title": "COVID-19 responses restricted abilities and aspirations for mobility and migration: insights from diverse cities in four continents.", "authors": [{"family": "Jolivet", "given": "Dominique", "initials": "D"}, {"family": "Fransen", "given": "Sonja", "initials": "S", "orcid": "0000-0002-7709-4418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/974425d862624044868ef165bca12048.json"}}, {"family": "Adger", "given": "William Neil", "initials": "WN", "orcid": "0000-0003-4244-2854", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c8a100ec8be42b7bb612dcb9f9ef6ab.json"}}, {"family": "F\u00e1bos", "given": "Anita", "initials": "A", "orcid": "0000-0001-6178-6439", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d17ce3e46d3645dfa4caf5012d4d6499.json"}}, {"family": "Abu", "given": "Mumuni", "initials": "M"}, {"family": "Allen", "given": "Charlotte", "initials": "C"}, {"family": "Boyd", "given": "Emily", "initials": "E", "orcid": "0000-0002-1643-9718", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ad7922a45d94ca2b93584b4835ab1f4.json"}}, {"family": "Carr", "given": "Edward R", "initials": "ER", "orcid": "0000-0001-7784-471X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ac45aa9461b4a42b481371372941be6.json"}}, {"family": "Codjoe", "given": "Samuel Nii Ardey", "initials": "SNA"}, {"family": "Gavonel", "given": "Maria Franco", "initials": "MF", "orcid": "0000-0003-2377-5987", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a3bea59d3fa4acc95f7ec4e9487fa7f.json"}}, {"family": "Gemenne", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Rocky", "given": "Mahmudol Hasan", "initials": "MH"}, {"family": "Lantz", "given": "Jozefina", "initials": "J"}, {"family": "Maculule", "given": "Domingos", "initials": "D"}, {"family": "de Campos", "given": "Ricardo Safra", "initials": "RS"}, {"family": "Siddiqui", "given": "Tasneem", "initials": "T"}, {"family": "Zickgraf", "given": "Caroline", "initials": "C"}], "type": "journal article", "published": "2023-05-18", "journal": {"title": "Humanit Soc Sci Commun", "issn": "2662-9992", "issn-l": null, "volume": "10", "issue": "1", "pages": "250"}, "abstract": "Research on the impacts of COVID-19 on mobility has focused primarily on the increased health vulnerabilities of involuntary migrant and displaced populations. But virtually all migration flows have been truncated and altered because of reduced economic and mobility opportunities of migrants. Here we use a well-established framework of migration decision-making, whereby individual decisions combine the aspiration and ability to migrate, to explain how public responses to the COVID-19 pandemic alter migration patterns among urban populations across the world. The principal responses to COVID-19 pandemic that affected migration are: 1) through travel restrictions and border closures, 2) by affecting abilities to move through economic and other means, and 3) by affecting aspirations to move. Using in-depth qualitative data collected in six cities in four continents (Accra, Amsterdam, Brussels, Dhaka, Maputo, and Worcester), we explore how populations with diverse levels of education and occupations were affected in their current and future mobility decisions. We use data from interviews with sample of internal and international migrants and non-migrants during the 2020 COVID-19 pandemic outbreak to identify the mechanisms through which the pandemic affected their mobility decisions. The results show common processes across the different geographical contexts: individuals perceived increased risks associated with further migration, which affected their migration aspirations, and had reduced abilities to migrate, all of which affected their migration decision-making processes. The results also reveal stark differences in perceived and experienced migration decision-making across precarious migrant groups compared to high-skilled and formally employed international migrants in all settings. This precarity of place is particularly evident in low-income marginalised populations.", "doi": "10.1057/s41599-023-01721-y", "pmid": "37250294", "labels": {"Funder: H2020": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10195652"}, {"db": "pii", "key": "1721"}], "notes": [], "created": "2023-10-04T05:11:03.101Z", "modified": "2023-10-04T07:05:57.264Z"}, {"entity": "publication", "iuid": "c44cf098ca084ba9a279d94f886e5650", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c44cf098ca084ba9a279d94f886e5650.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c44cf098ca084ba9a279d94f886e5650"}}, "title": "Telemedicine for diabetes management during COVID-19: what we have learnt, what and how to implement.", "authors": [{"family": "Rosta", "given": "Laszlo", "initials": "L"}, {"family": "Menyhart", "given": "Adrienn", "initials": "A"}, {"family": "Mahmeed", "given": "Wael Al", "initials": "WA"}, {"family": "Al-Rasadi", "given": "Khalid", "initials": "K"}, {"family": "Al-Alawi", "given": "Kamila", "initials": "K"}, {"family": "Banach", "given": "Maciej", "initials": "M"}, {"family": "Banerjee", "given": "Yajnavalka", "initials": "Y"}, {"family": "Ceriello", "given": "Antonio", "initials": "A"}, {"family": "Cesur", "given": "Mustafa", "initials": "M"}, {"family": "Cosentino", "given": "Francesco", "initials": "F"}, {"family": "Firenze", "given": "Alberto", "initials": "A"}, {"family": "Galia", "given": "Massimo", "initials": "M"}, {"family": "Goh", "given": "Su-Yen", "initials": "S"}, {"family": "Janez", "given": "Andrej", "initials": "A"}, {"family": "Kalra", "given": "Sanjay", "initials": "S"}, {"family": "Kapoor", "given": "Nitin", "initials": "N"}, {"family": "Lessan", "given": "Nader", "initials": "N"}, {"family": "Lotufo", "given": "Paulo", "initials": "P"}, {"family": "Papanas", "given": "Nikolaos", "initials": "N"}, {"family": "Rizvi", "given": "Ali A", "initials": "AA"}, {"family": "Sahebkar", "given": "Amirhossein", "initials": "A"}, {"family": "Santos", "given": "Raul D", "initials": "RD"}, {"family": "Stoian", "given": "Anca Pantea", "initials": "AP"}, {"family": "Toth", "given": "Peter P", "initials": "PP"}, {"family": "Viswanathan", "given": "Vijay", "initials": "V"}, {"family": "Kempler", "given": "Peter", "initials": "P"}, {"family": "Rizzo", "given": "Manfredi", "initials": "M"}], "type": "journal article", "published": "2023-05-17", "journal": {"title": "Front Endocrinol (Lausanne)", "issn": "1664-2392", "issn-l": null, "volume": "14", "issue": null, "pages": "1129793"}, "abstract": "The past two decades have witnessed telemedicine becoming a crucial part of health care as a method to facilitate doctor-patient interaction. Due to technological developments and the incremental acquisition of experience in its use, telemedicine's advantages and cost-effectiveness has led to it being recognised as specifically relevant to diabetology. However, the pandemic created new challenges for healthcare systems and the rate of development of digital services started to grow exponentially. It was soon discovered that COVID-19-infected patients with diabetes had an increased risk of both mortality and debilitating sequelae. In addition, it was observed that this higher risk could be attenuated primarily by maintaining optimal control of the patient's glucose metabolism. As opportunities for actual physical doctor-patient visits became restricted, telemedicine provided the most convenient opportunity to communicate with patients and maintain delivery of care. The wide range of experiences of health care provision during the pandemic has led to the development of several excellent strategies regarding the applicability of telemedicine across the whole spectrum of diabetes care. The continuation of these strategies is likely to benefit clinical practice even after the pandemic crisis is over.", "doi": "10.3389/fendo.2023.1129793", "pmid": "37265696", "labels": {"Category: Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC10231679"}], "notes": [], "created": "2023-10-04T09:33:13.651Z", "modified": "2023-10-04T11:20:33.345Z"}, {"entity": "publication", "iuid": "316bc4a243ca4651b3b53d1cd380f377", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/316bc4a243ca4651b3b53d1cd380f377.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/316bc4a243ca4651b3b53d1cd380f377"}}, "title": "Ultra-Processed Food vs. Fruit and Vegetable Consumption before and during the COVID-19 Pandemic among Greek and Swedish Students.", "authors": [{"family": "Dhammawati", "given": "Friska", "initials": "F"}, {"family": "Fagerberg", "given": "Petter", "initials": "P"}, {"family": "Diou", "given": "Christos", "initials": "C", "orcid": "0000-0002-2461-1928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73e37fdd544145f7a09e5d09a91a3408.json"}}, {"family": "Mavrouli", "given": "Ioanna", "initials": "I"}, {"family": "Koukoula", "given": "Evangelia", "initials": "E"}, {"family": "Lekka", "given": "Eirini", "initials": "E"}, {"family": "Stefanopoulos", "given": "Leandros", "initials": "L", "orcid": "0000-0002-2682-5639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff30bac728204c79adb77b08c9f6c0bc.json"}}, {"family": "Maglaveras", "given": "Nicos", "initials": "N", "orcid": "0000-0002-4919-0664", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02ae3a48f10d4c60971b80f807381fe1.json"}}, {"family": "Heimeier", "given": "Rachel", "initials": "R", "orcid": "0000-0003-4798-1312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0e753a7fa1047a484f8abb065cda4a8.json"}}, {"family": "Karavidopoulou", "given": "Youla", "initials": "Y", "orcid": "0000-0003-3648-9533", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4df84c2905245249ae478b9fbb99124.json"}}, {"family": "Ioakimidis", "given": "Ioannis", "initials": "I"}], "type": "journal article", "published": "2023-05-16", "journal": {"title": "Nutrients", "issn": "2072-6643", "issn-l": null, "volume": "15", "issue": "10", "pages": null}, "abstract": "The COVID-19 pandemic has impacted children's lifestyles, including dietary behaviors. Of particular concern among these behaviors is the heightened prevalence of ultra-processed food (UPF) consumption, which has been linked to the development of obesity and related non-communicable diseases. The present study examines the changes in (1) UPF and (2) vegetable and/or fruit consumption among school-aged children in Greece and Sweden before and during the COVID-19 pandemic.\r\n\r\nThe analyzed dataset consisted of main meal pictures (breakfast, lunch, and dinner) captured by 226 Greek students (94 before the pandemic and 132 during the pandemic) and 421 Swedish students (293 before and 128 during the pandemic), aged 9-18, who voluntarily reported their meals using a mobile application. The meal pictures were collected over four-month periods over two consecutive years; namely, between the 20th of August and the 20th of December in 2019 (before the COVID-19 outbreak) and the same period in 2020 (during the COVID-19 outbreak). The collected pictures were annotated manually by a trained nutritionist. A chi-square test was performed to evaluate the differences in proportions before versus during the pandemic.\r\n\r\nIn total, 10,770 pictures were collected, including 6474 pictures from before the pandemic and 4296 pictures collected during the pandemic. Out of those, 86 pictures were excluded due to poor image quality, and 10,684 pictures were included in the final analyses (4267 pictures from Greece and 6417 pictures from Sweden). The proportion of UPF significantly decreased during vs. before the pandemic in both populations (50% vs. 46%, p = 0.010 in Greece, and 71% vs. 66%, p < 0.001 in Sweden), while the proportion of vegetables and/or fruits significantly increased in both cases (28% vs. 35%, p < 0.001 in Greece, and 38% vs. 42%, p = 0.019 in Sweden). There was a proportional increase in meal pictures containing UPF among boys in both countries. In Greece, both genders showed an increase in vegetables and/or fruits, whereas, in Sweden, the increase in fruit and/or vegetable consumption was solely observed among boys.\r\n\r\nThe proportion of UPF in the Greek and Swedish students' main meals decreased during the COVID-19 pandemic vs. before the pandemic, while the proportion of main meals with vegetables and/or fruits increased.", "doi": "10.3390/nu15102321", "pmid": "37242204", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10222979"}, {"db": "pii", "key": "nu15102321"}], "notes": [], "created": "2023-10-04T05:11:00.506Z", "modified": "2023-10-04T07:04:21.238Z"}, {"entity": "publication", "iuid": "1535d377dc0043e6915cc2128df2a520", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1535d377dc0043e6915cc2128df2a520.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1535d377dc0043e6915cc2128df2a520"}}, "title": "Cardiorespiratory dysautonomia in post-COVID-19 condition: Manifestations, mechanisms and management.", "authors": [{"family": "Fedorowski", "given": "Artur", "initials": "A"}, {"family": "Ols\u00e9n", "given": "Monika Fagevik", "initials": "MF"}, {"family": "Nikesj\u00f6", "given": "Frida", "initials": "F"}, {"family": "Janson", "given": "Christer", "initials": "C", "orcid": "0000-0001-5093-6980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba296cda8ef74430ad5457e71b7dae94.json"}}, {"family": "Bruchfeld", "given": "Judith", "initials": "J"}, {"family": "Lerm", "given": "Maria", "initials": "M", "orcid": "0000-0002-5092-9892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a326e1fb7efa4c4f8f59e7572f6b83bc.json"}}, {"family": "Hedman", "given": "Kristofer", "initials": "K", "orcid": "0000-0002-3751-7180", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30b778f33408413eaf0cce6023e9dfa3.json"}}], "type": "journal article", "published": "2023-05-14", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "A significant proportion of COVID-19 patients experience debilitating symptoms for months after the acute infection. According to recent estimates, approximately 1 out of 10 COVID-19 convalescents reports persistent health issues more than 3 months after initial recovery. This 'post-COVID-19 condition' may include a large variety of symptoms from almost all domains and organs, and for some patients it may mean prolonged sick-leave, homestay and strongly limited activities of daily life. In this narrative review, we focus on the symptoms and signs of post-COVID-19 condition in adults - particularly those associated with cardiovascular and respiratory systems, such as postural orthostatic tachycardia syndrome or airway disorders - and explore the evidence for chronic autonomic dysfunction as a potential underlying mechanism. The most plausible hypotheses regarding cellular and molecular mechanisms behind the wide spectrum of observed symptoms - such as lingering viruses, persistent inflammation, impairment in oxygen sensing systems and circulating antibodies directed to blood pressure regulatory components - are discussed. In addition, an overview of currently available pharmacological and non-pharmacological treatment options is presented.", "doi": "10.1111/joim.13652", "pmid": "37183186", "labels": {"Category: Post-COVID": null, "Type: Review": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:09:48.818Z", "modified": "2023-10-04T06:10:33.707Z"}, {"entity": "publication", "iuid": "721ff2ee08c24dc48b1f10b421760f89", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/721ff2ee08c24dc48b1f10b421760f89.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/721ff2ee08c24dc48b1f10b421760f89"}}, "title": "It turned into something else: patients' long-term experiences of transitions to or from telepsychotherapy during the COVID-19 pandemic.", "authors": [{"family": "von Below", "given": "Camilla", "initials": "C"}, {"family": "Bergsten", "given": "Jenny", "initials": "J"}, {"family": "Midbris", "given": "Ther\u00e9se", "initials": "T"}, {"family": "Philips", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Werbart", "given": "Andrzej", "initials": "A"}], "type": "journal article", "published": "2023-05-12", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "14", "issue": null, "pages": "1142233"}, "abstract": "The shift from in-person therapy to telepsychotherapy during the COVID-19 pandemic was unprepared for, sudden, and inevitable. This study explored patients' long-term experiences of transitions to telepsychotherapy and back to the office.\r\n\r\nData were collected approximately two years after the declaration of COVID-19 as a pandemic. Eleven patients were interviewed (nine women and two men, aged 28 to 56, six in psychodynamic psychotherapy, five in CBT). Treatments switched between in-person and video/telephone sessions. Interview transcripts were analyzed applying the qualitative methodology of inductive thematic analysis.\r\n\r\n(1) The patients experienced the process in telepsychotherapy as impeded. Interventions were difficult to understand and lost impact. Routines surrounding the therapy sessions were lost. Conversations were less serious and lost direction. (2) Understanding was made more difficult when the nuances of non-verbal communication were lost. (3) The emotional relationship was altered. Remote therapy was perceived as something different from regular therapy, and once back in the therapy room, the patients felt that therapy started anew. The emotional presence was experienced as weakened, but some of the patients found expressing their feelings easier in the absence of bodily co-presence. According to the patients, in-person presence contributed to their security and trust, whereas they felt that the therapists were different when working remotely, behaving in a more easygoing and familiar way, as well as more solution-focused, supportive and unprofessional, less understanding and less therapeutic. Despite this, (4) telepsychotherapy also gave the patients an opportunity to take therapy with them into their everyday lives.\r\n\r\nThe results suggest that in the long run, remote psychotherapy was seen as a good enough alternative when needed. The present study indicates that format alternations have an impact on which interventions can be implemented, which can have important implications for psychotherapy training and supervision in an era when telepsychotherapy is becoming increasingly common.", "doi": "10.3389/fpsyg.2023.1142233", "pmid": "37251023", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10213395"}], "notes": [], "created": "2023-10-04T05:11:38.740Z", "modified": "2023-10-04T07:17:13.780Z"}, {"entity": "publication", "iuid": "80b404bff0f7468b8e2191f370d09e8f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/80b404bff0f7468b8e2191f370d09e8f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/80b404bff0f7468b8e2191f370d09e8f"}}, "title": "A novel precision-serology assay for SARS-CoV-2 infection based on linear B-cell epitopes of Spike protein.", "authors": [{"family": "Lundin", "given": "Samuel B", "initials": "SB"}, {"family": "Kann", "given": "Hanna", "initials": "H"}, {"family": "Fulurija", "given": "Alma", "initials": "A"}, {"family": "Andersson", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Nakka", "given": "Sravya S", "initials": "SS"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "L"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Harandi", "given": "Ali M", "initials": "AM"}], "type": "journal article", "published": "2023-05-12", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "1166924"}, "abstract": "The COVID-19 pandemic illustrates the need for serology diagnostics with improved accuracy. While conventional serology based on recognition of entire proteins or subunits thereof has made significant contribution to the antibody assessment space, it often suffers from sub-optimal specificity. Epitope-based, high-precision, serology assays hold potential to capture the high specificity and diversity of the immune system, hence circumventing the cross-reactivity with closely related microbial antigens.\r\n\r\nWe herein report mapping of linear IgG and IgA antibody epitopes of the SARS-CoV-2 Spike (S) protein in samples from SARS-CoV-2 exposed individuals along with certified SARS-CoV-2 verification plasma samples using peptide arrays.\r\n\r\nWe identified 21 distinct linear epitopes. Importantly, we showed that pre-pandemic serum samples contain IgG antibodies reacting to the majority of protein S epitopes, most likely as a result of prior infection with seasonal coronaviruses. Only 4 of the identified SARS-CoV-2 protein S linear epitopes were specific for SARS-CoV-2 infection. These epitopes are located at positions 278-298 and 550-586, just proximal and distal to the RBD, as well as at position 1134-1156 in the HR2 subdomain and at 1248-1271 in the C-terminal subdomain of protein S. To substantiate the applicability of our findings, we tested three of the high-accuracy protein S epitopes in a Luminex assay, using a certified validation plasma sample set from SARS-CoV-2 infected individuals. The Luminex results were well aligned with the peptide array results, and correlated very well with in-house and commercial immune assays for RBD, S1 and S1/S2 domains of protein S.\r\n\r\nWe present a comprehensive mapping of linear B-cell epitopes of SARS-CoV-2 protein S, that identifies peptides suitable for a precision serology assay devoid of cross-reactivity. These results have implications for development of highly specific serology test for exposure to SARS-CoV-2 and other members of the coronaviridae family, as well as for rapid development of serology tests for future emerging pandemic threats.", "doi": "10.3389/fimmu.2023.1166924", "pmid": "37251407", "labels": {"Category: Proteins": null, "Funder: VR": null, "Funder: Vinnova": null, "Category: Serology": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC10213285"}], "notes": [], "created": "2023-10-04T05:08:59.564Z", "modified": "2023-10-04T05:52:28.750Z"}, {"entity": "publication", "iuid": "c5dbc692903546b79ffa2df414f5fcbf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5dbc692903546b79ffa2df414f5fcbf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5dbc692903546b79ffa2df414f5fcbf"}}, "title": "Validation of myocarditis diagnoses in the Swedish patient register for analyses of potential adverse reactions to COVID-19 vaccines.", "authors": [{"family": "Gedeborg", "given": "Rolf", "initials": "R"}, {"family": "Holm", "given": "Lennart", "initials": "L"}, {"family": "Feltelius", "given": "Nils", "initials": "N"}, {"family": "Sundstr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Eggers", "given": "Kai M", "initials": "KM"}, {"family": "Nurminen", "given": "Marja-Leena", "initials": "M"}, {"family": "Gr\u00fcnewald", "given": "Maria", "initials": "M"}, {"family": "Pihlstr\u00f6m", "given": "Nicklas", "initials": "N"}, {"family": "Zethelius", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Ljung", "given": "Rickard", "initials": "R"}], "type": "journal article", "published": "2023-05-11", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "issn-l": "0300-9734", "volume": "128", "issue": null, "pages": null}, "abstract": "Coronavirus disease 2019 (COVID-19) mRNA vaccines are associated with an increased risk of myocarditis using hospital discharge diagnoses as an outcome. The validity of these register-based diagnoses is uncertain.\r\n\r\nPatient records for subjects < 40 years of age and a diagnosis of myocarditis in the Swedish National Patient Register were manually reviewed. Brighton Collaboration diagnosis criteria for myocarditis were applied based on patient history, clinical examination, laboratory data, electrocardiograms, echocardiography, magnetic resonance imaging and myocardial biopsy. Poisson regression was used to estimate incidence rate ratios, comparing the register-based outcome variable to validated outcomes. Interrater reliability was assessed by a blinded re-evaluation.\r\n\r\nOverall, 95.6% (327/342) of cases registered as myocarditis were confirmed (definite, probable or possible myocarditis according to Brighton Collaboration diagnosis criteria, positive predictive value 0.96 [95% CI 0.93-0.98]). Of the 4.4% (15/342) cases reclassified as no myocarditis or as insufficient information, two cases had been exposed to the COVID-19 vaccine no more than 28 days before the myocarditis diagnosis, two cases were exposed >28 days before admission and 11 cases were unexposed to the vaccine. The reclassification had only minor impact on incidence rate ratios for myocarditis following COVID-19 vaccination. In total, 51 cases were sampled for a blinded re-evaluation. Of the 30 randomly sampled cases initially classified as either definite or probably myocarditis, none were re-classified after re-evaluation. Of the in all 15 cases initially classified as no myocarditis or insufficient information, 7 were after re-evaluation re-classified as probable or possible myocarditis. This re-classification was mostly due to substantial variability in electrocardiogram interpretation.\r\n\r\nThis validation of register-based diagnoses of myocarditis by manual patient record review confirmed the register diagnosis in 96% of cases and had high interrater reliability. Reclassification had only a minor impact on the incidence rate ratios for myocarditis following COVID-19 vaccination.", "doi": "10.48101/ujms.v128.9290", "pmid": "37223633", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10202079"}, {"db": "pii", "key": "9290"}], "notes": [], "created": "2023-10-04T05:10:23.710Z", "modified": "2023-10-04T06:36:38.159Z"}, {"entity": "publication", "iuid": "d2755f6aac6b4f11beef7264eb00f65d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d2755f6aac6b4f11beef7264eb00f65d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d2755f6aac6b4f11beef7264eb00f65d"}}, "title": "Social and moral psychology of COVID-19 across 69 countries.", "authors": [{"family": "Azevedo", "given": "Flavio", "initials": "F", "orcid": "0000-0001-9000-8513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7864cb0e9bf846d6b69a6a5bf65cbd91.json"}}, {"family": "Pavlovi\u0107", "given": "Tomislav", "initials": "T"}, {"family": "R\u00eago", "given": "Gabriel G", "initials": "GG"}, {"family": "Ay", "given": "F Ceren", "initials": "FC"}, {"family": "Gjoneska", "given": "Biljana", "initials": "B", "orcid": "0000-0003-1200-6672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37b6c574b4824a4eae77730b96814547.json"}}, {"family": "Etienne", "given": "Tom W", "initials": "TW"}, {"family": "Ross", "given": "Robert M", "initials": "RM", "orcid": "0000-0001-8711-1675", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49cb2e4d713844729ee7d64213f3cdbe.json"}}, {"family": "Sch\u00f6negger", "given": "Philipp", "initials": "P"}, {"family": "Ria\u00f1o-Moreno", "given": "Juli\u00e1n C", "initials": "JC"}, {"family": "Cichocka", "given": "Aleksandra", "initials": "A", "orcid": "0000-0003-1703-1586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0cc1202c8fb34d07952c7d99ab43bf87.json"}}, {"family": "Capraro", "given": "Valerio", "initials": "V"}, {"family": "Cian", "given": "Luca", "initials": "L"}, {"family": "Longoni", "given": "Chiara", "initials": "C"}, {"family": "Chan", "given": "Ho Fai", "initials": "HF", "orcid": "0000-0002-7281-5212", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f60a9007efb4abf8a952c375ea1abdf.json"}}, {"family": "Van Bavel", "given": "Jay J", "initials": "JJ", "orcid": "0000-0002-2520-0442", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/344fbd5da7bc4259b3f70839f401c84c.json"}}, {"family": "Sj\u00e5stad", "given": "Hallgeir", "initials": "H"}, {"family": "Nezlek", "given": "John B", "initials": "JB"}, {"family": "Alfano", "given": "Mark", "initials": "M"}, {"family": "Gelfand", "given": "Michele J", "initials": "MJ"}, {"family": "Birtel", "given": "Mich\u00e8le D", "initials": "MD"}, {"family": "Cislak", "given": "Aleksandra", "initials": "A"}, {"family": "Lockwood", "given": "Patricia L", "initials": "PL", "orcid": "0000-0001-7195-9559", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d77d4779b0ff456b906f2001dc3aa36f.json"}}, {"family": "Abts", "given": "Koen", "initials": "K"}, {"family": "Agadullina", "given": "Elena", "initials": "E"}, {"family": "Aruta", "given": "John Jamir Benzon", "initials": "JJB"}, {"family": "Besharati", "given": "Sahba Nomvula", "initials": "SN"}, {"family": "Bor", "given": "Alexander", "initials": "A", "orcid": "0000-0002-2624-9221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/048bdb252beb4b2599b619f41ace6277.json"}}, {"family": "Choma", "given": "Becky L", "initials": "BL"}, {"family": "Crabtree", "given": "Charles David", "initials": "CD", "orcid": "0000-0001-5144-8671", "researcher": {"href": 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"0000-0003-1431-568X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12d5285132e14b7bbca2607a084fb449.json"}}, {"family": "Yilmaz", "given": "Onurcan", "initials": "O"}, {"family": "Yogeeswaran", "given": "Kumar", "initials": "K", "orcid": "0000-0002-1978-5077", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ef06acca6df4009bd0ab178af33551b.json"}}, {"family": "Ziemer", "given": "Carolin-Theresa", "initials": "C"}, {"family": "Zwaan", "given": "Rolf A", "initials": "RA"}, {"family": "Boggio", "given": "Paulo S", "initials": "PS"}, {"family": "Sampaio", "given": "Waldir M", "initials": "WM", "orcid": "0000-0002-6066-4314", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/003b9727584c4c2bb054a6ed2448c809.json"}}], "type": "dataset", "published": "2023-05-11", "journal": {"title": "Sci Data", "issn": "2052-4463", "issn-l": null, "volume": "10", "issue": "1", "pages": "272"}, "abstract": "The COVID-19 pandemic has affected all domains of human life, including the economic and social fabric of societies. One of the central strategies for managing public health throughout the pandemic has been through persuasive messaging and collective behaviour change. To help scholars better understand the social and moral psychology behind public health behaviour, we present a dataset comprising of 51,404 individuals from 69 countries. This dataset was collected for the International Collaboration on Social & Moral Psychology of COVID-19 project (ICSMP COVID-19). This social science survey invited participants around the world to complete a series of moral and psychological measures and public health attitudes about COVID-19 during an early phase of the COVID-19 pandemic (between April and June 2020). The survey included seven broad categories of questions: COVID-19 beliefs and compliance behaviours; identity and social attitudes; ideology; health and well-being; moral beliefs and motivation; personality traits; and demographic variables. We report both raw and cleaned data, along with all survey materials, data visualisations, and psychometric evaluations of key variables.", "doi": "10.1038/s41597-023-02080-8", "pmid": "37169799", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10173241"}, {"db": "pii", "key": "10.1038/s41597-023-02080-8"}], "notes": [], "created": "2023-10-04T05:10:30.964Z", "modified": "2023-10-04T06:44:19.514Z"}, {"entity": "publication", "iuid": "fc726a79a3c0468087e48d2b34902664", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc726a79a3c0468087e48d2b34902664.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc726a79a3c0468087e48d2b34902664"}}, "title": "Current tobacco use and SARS-CoV-2 infection in two Norwegian population-based cohorts.", "authors": [{"family": "Caspersen", "given": "Ida Henriette", "initials": "IH"}, {"family": "Trogstad", "given": "Lill", "initials": "L"}, {"family": "Galanti", "given": "Maria Rosaria", "initials": "MR"}, {"family": "Karvonen", "given": "Sakari", "initials": "S"}, {"family": "Pe\u00f1a", "given": "Sebasti\u00e1n", "initials": "S"}, {"family": "Shaaban", "given": "Ahmed Nabil", "initials": "AN"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}, {"family": "Magnus", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2023-05-10", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "23", "issue": "1", "pages": "846"}, "abstract": "Clear evidence of an increased risk for SARS-CoV-2 infection among smokers has not been established. We aimed to investigate associations between cigarette smoking or use of snus (snuff) and other nicotine-containing products and a positive SARS-CoV-2 test, taking test behavior into account.\r\n\r\nCurrent tobacco use and testing behavior during the pandemic were recorded by adult participants from the Norwegian Mother, Father and Child Cohort Study and The Norwegian Influenza Pregnancy Cohort. SARS-CoV-2 infection status was obtained from The Norwegian Surveillance System for Communicable Diseases (MSIS) in May 2021 (n = 78,860) and antibody measurements (n = 5581). We used logistic regression models stratified by gender and adjusted for age, education, region, number of household members, and work situation.\r\n\r\nSnus use was more common among men (26%) than women (9%) and more prevalent than cigarette smoking. We found no clear associations between cigarette smoking or snus and a COVID-19 diagnosis among men. Associations among women were conflicting, indicating that cigarette smoke was negatively associated with a diagnosis (OR 0.51, 95% CI 0.35, 0.75), while no association was found for snus use (OR 1.07, 95% CI 0.86, 1.34). Compared with non-users of tobacco, both cigarette smokers and snus users had increased odds of being tested for SARS-CoV-2.\r\n\r\nCigarette smoking, but not snus use, was negatively associated with SARS-CoV-2 infection in women. The lack of an association between snus use and SARS-CoV-2 infection in this population with prevalent snus use does not support the hypothesis of a protective effect of nicotine.", "doi": "10.1186/s12889-023-15822-5", "pmid": "37165385", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10170041"}, {"db": "pii", "key": "10.1186/s12889-023-15822-5"}], "notes": [], "created": "2023-10-04T05:08:57.146Z", "modified": "2023-10-04T05:50:44.009Z"}, {"entity": "publication", "iuid": "34b32b64758d4e9eb5e573fc545c5bbf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/34b32b64758d4e9eb5e573fc545c5bbf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/34b32b64758d4e9eb5e573fc545c5bbf"}}, "title": "Articulations of 'Funeral' in Swedish Newspapers During the Covid-19 Pandemic.", "authors": [{"family": "Jarnkvist", "given": "Karin", "initials": "K", "orcid": "0000-0002-6408-2952", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3418f7feda5247efae3f9bb8c785a6e3.json"}}], "type": "journal article", "published": "2023-05-10", "journal": {"title": "Omega (Westport)", "issn": "1541-3764", "issn-l": null, "volume": null, "issue": null, "pages": "302228231174601"}, "abstract": "This article explores how 'funeral' was articulated in Swedish newspapers during the Covid-19 pandemic and how such articulations relate to power and ideology. Articles from the six most prominent Swedish newspapers, published over 2 years, have been analyzed using critical discourse analysis and intersectionality. The study reveals three funeral discourses dominating during different periods of the pandemic: 'Funeral as a risk,' 'Funeral as an essential ritual,' and 'Funeral as a profession.' Altogether, the three discourses expose an ideal of 'the responsible mourner.' This rational woman follows the funeral restrictions and arranges a church funeral shortly after the death of a relative. The 'good funeral' is portrayed as a church funeral with physically present mourners, performed according to the deceased's will and in honor of the dead. The 'bad funeral,' described as the opposite of the 'good funeral,' dominates the understanding of the pandemic funeral situation.", "doi": "10.1177/00302228231174601", "pmid": "37165654", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:11:36.308Z", "modified": "2023-10-04T07:15:59.305Z"}, {"entity": "publication", "iuid": "1fc932cb2ce44153aa4bb828ae2ebc7d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1fc932cb2ce44153aa4bb828ae2ebc7d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1fc932cb2ce44153aa4bb828ae2ebc7d"}}, "title": "Mucosal immunization with lactiplantibacillus plantarum-displaying recombinant SARS-CoV-2 epitopes on the surface induces humoral and mucosal immune responses in mice.", "authors": [{"family": "Hwang", "given": "In-Chan", "initials": "I"}, {"family": "Valeriano", "given": "Valerie Diane", "initials": "VD"}, {"family": "Song", "given": "Ji Hoon", "initials": "JH"}, {"family": "Pereira", "given": "Marcela", "initials": "M"}, {"family": "Oh", "given": "Ju Kyoung", "initials": "JK"}, {"family": "Han", "given": "Kyudong", "initials": "K"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Kang", "given": "Dae-Kyung", "initials": "D"}], "type": "journal article", "published": "2023-05-09", "journal": {"title": "Microb Cell Fact", "issn": "1475-2859", "issn-l": null, "volume": "22", "issue": "1", "pages": "96"}, "abstract": "The use of probiotic lactic acid bacteria as a mucosal vaccine vector is considered a promising alternative compared to the use of other microorganisms because of its \"Generally Regarded as Safe\" status, its potential adjuvant properties, and its tolerogenicity to the host. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease (COVID-19), is highly transmissible and pathogenic. This study aimed to determine the potential of Lactiplantibacillus plantarum expressing SARS-CoV-2 epitopes as a mucosal vaccine against SARS-CoV-2.\r\n\r\nIn this study, the possible antigenic determinants of the spike (S1-1, S1-2, S1-3, and S1-4), membrane (ME1 and ME2), and envelope (E) proteins of SARS-CoV-2 were predicted, and recombinant L. plantarum strains surface-displaying these epitopes were constructed. Subsequently, the immune responses induced by these recombinant strains were compared in vitro and in vivo. Most surface-displayed epitopes induced pro-inflammatory cytokines [tumor necrosis factor alpha (TNF-\u03b1 and interleukin (IL)-6] and anti-inflammatory cytokines (IL-10) in lipopolysaccharide-induced RAW 264.7, with the highest anti-inflammatory to pro-inflammatory cytokine ratio in the S1-1 and S1-2 groups, followed by that in the S1-3 group. When orally administered of recombinant L. plantarum expressing SARS-CoV-2 epitopes in mice, all epitopes most increased the expression of IL-4, along with induced levels of TNF-\u03b1, interferon-gamma, and IL-10, specifically in spike protein groups. Thus, the surface expression of epitopes from the spike S1 protein in L. plantarum showed potential immunoregulatory effects, suggesting its ability to potentially circumvent hyperinflammatory states relevant to monocyte/macrophage cell activation. At 35 days post immunization (dpi), serum IgG levels showed a marked increase in the S1-1, S1-2, and S1-3 groups. Fecal IgA levels increased significantly from 21 dpi in all the antigen groups, but the boosting effect after 35 dpi was explicitly observed in the S1-1, S1-2, and S1-3 groups. Thus, the oral administration of SARS-CoV-2 antigens into mice induced significant humoral and mucosal immune responses.\r\n\r\nThis study suggests that L. plantarum is a potential vector that can effectively deliver SARS-CoV-2 epitopes to intestinal mucosal sites and could serve as a novel approach for SARS-CoV-2 mucosal vaccine development.", "doi": "10.1186/s12934-023-02100-7", "pmid": "37161468", "labels": {"Funder: VR": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10169176"}, {"db": "pii", "key": "10.1186/s12934-023-02100-7"}], "notes": [], "created": "2023-10-04T05:09:02.049Z", "modified": "2023-10-04T05:54:36.250Z"}, {"entity": "publication", "iuid": "5dd3c0e88dc24abe95c6c5328fec4d23", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5dd3c0e88dc24abe95c6c5328fec4d23.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5dd3c0e88dc24abe95c6c5328fec4d23"}}, "title": "Vaccine effectiveness of BNT162b2 mRNA Covid-19 Vaccine in Children below 5 Years in German Primary Care", "authors": [{"family": "Strumann", "given": "Christoph", "initials": "C", "orcid": "0000-0003-2725-6543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ea86e19543e4c0bb8ff7820e029fb1e.json"}}, {"family": "Ranzani", "given": "Otavio", "initials": "O", "orcid": "0000-0002-4677-6862", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/891f1de2767b44efbca8b6e7f5e18874.json"}}, {"family": "Moor", "given": "Jeanne", "initials": "J"}, {"family": "Berner", "given": "Reinhard", "initials": "R", "orcid": "0000-0002-6216-9173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2afcdc91e9424d9285eeb1526874c18b.json"}}, {"family": "T\u00f6pfner", "given": "Nicole", "initials": "N", "orcid": "0000-0002-9693-4419", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8c908b0701b4c6b9fb6e26acb479b8f.json"}}, {"family": "Chao", "given": "Cho Ming", "initials": "CM", "orcid": "0000-0002-0034-8264", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e1c91c06f144eb5bfca0a7126b69e11.json"}}, {"family": "Moor", "given": "Matthias B", "initials": "MB", "orcid": "0000-0002-7717-651X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01cf6b66149b43339c7a79fde358b702.json"}}], "type": "posted-content", "published": "2023-05-08", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.05.05.23289209", "pmid": null, "labels": {"Type: Preprint": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:11:59.151Z", "modified": "2023-10-04T07:25:20.770Z"}, {"entity": "publication", "iuid": "cfbc4759b84b4935802122112005ce87", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfbc4759b84b4935802122112005ce87.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfbc4759b84b4935802122112005ce87"}}, "title": "Vaccine-induced correlate of protection against fatal COVID-19 in older and frail adults during waves of neutralization-resistant variants of concern: an observational study.", "authors": [{"family": "Vikstr\u00f6m", "given": "Linnea", "initials": "L"}, {"family": "Fj\u00e4llstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Gwon", "given": "Yong-Dae", "initials": "Y"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Wigren-Bystr\u00f6m", "given": "Julia", "initials": "J"}, {"family": "Evander", "given": "Magnus", "initials": "M"}, {"family": "Bladh", "given": "Oscar", "initials": "O"}, {"family": "Widerstr\u00f6m", "given": "Micael", "initials": "M"}, {"family": "Molnar", "given": "Christian", "initials": "C"}, {"family": "Rasmussen", "given": "Gunl\u00f6g", "initials": "G"}, {"family": "Bennet", "given": "Louise", "initials": "L"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}, {"family": "Tevell", "given": "Staffan", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}], "type": "journal article", "published": "2023-05-06", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "issn-l": null, "volume": "30", "issue": null, "pages": "100646"}, "abstract": "To inform future preventive measures including repeated vaccinations, we have searched for a clinically useful immune correlate of protection against fatal COVID-19 among nursing homes residents.\r\n\r\nWe performed repeated capillary blood sampling with analysis of S-binding IgG in an open cohort of nursing home residents in Sweden. We analyzed immunological and registry data from 16 September 2021 to 31 August 2022 with follow-up of deaths to 30 September 2022. The study period included implementation of the 3rd and 4th mRNA monovalent vaccine doses and Omicron virus waves.\r\n\r\nA total of 3012 nursing home residents with median age 86 were enrolled. The 3rd mRNA dose elicited a 99-fold relative increase of S-binding IgG in blood and corresponding increase of neutralizing antibodies. The 4th mRNA vaccine dose boosted levels 3.8-fold. Half-life of S-binding IgG was 72 days. A total 528 residents acquired their first SARS-CoV-2 infection after the 3rd or the 4th vaccine dose and the associated 30-day mortality was 9.1%. We found no indication that levels of vaccine-induced antibodies protected against infection with Omicron VOCs. In contrast, the risk of death was inversely correlated to levels of S-directed IgG below the 20th percentile. The death risk plateaued at population average above the lower 35th percentile of S-binding IgG.\r\n\r\nIn the absence of neutralizing antibodies that protect from infection, quantification of S-binding IgG post vaccination may be useful to identify the most vulnerable for fatal COVID-19 among the oldest and frailest. This information is of importance for future strategies to protect vulnerable populations against neutralization resistant variants of concern.\r\n\r\nSwedish Research Council, SciLifeLab via Knut and Alice Wallenberg Foundation, VINNOVA. Swedish Healthcare Regions, and Erling Persson Foundation.", "doi": "10.1016/j.lanepe.2023.100646", "pmid": "37363799", "labels": {"Funder: VR": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10163377"}, {"db": "pii", "key": "S2666-7762(23)00065-0"}], "notes": [], "created": "2023-07-13T11:35:27.330Z", "modified": "2023-10-04T10:01:29.263Z"}, {"entity": "publication", "iuid": "8ad583f7951244339eefca386b4d8b31", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ad583f7951244339eefca386b4d8b31.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ad583f7951244339eefca386b4d8b31"}}, "title": "Knowledge and attitudes toward COVID-19 vaccination in Sudan: A cross-sectional study.", "authors": [{"family": "Badi", "given": "Safaa", "initials": "S"}, {"family": "Babiker", "given": "Loai Abdelgadir", "initials": "LA"}, {"family": "Aldow", "given": "Abdullah Yasseen", "initials": "AY"}, {"family": "Abas", "given": "Almigdad Badr Aldeen", "initials": "ABA"}, {"family": "Eisa", "given": "Mazen Abdelhafiez", "initials": "MA"}, {"family": "Abu-Ali", "given": "Mohamed Nour", "initials": "MN"}, {"family": "Abdella", "given": "Wagass Abdelrhman", "initials": "WA"}, {"family": "Marzouq", "given": "Mohamed Elsir", "initials": "ME"}, {"family": "Ahmed", "given": "Musaab", "initials": "M"}, {"family": "Omer", "given": "Abubakr Ali M", "initials": "AAM"}, {"family": "Ahmed", "given": "Mohamed H", "initials": "MH"}], "type": "journal article", "published": "2023-05-06", "journal": {"title": "AIMS Public Health", "issn": "2327-8994", "issn-l": null, "volume": "10", "issue": "2", "pages": "310-323"}, "abstract": "Vaccines are an essential part of public health interventions to mitigate the devastating health and non-health impacts of COVID-19 pandemic. Despite the fact that Sudan launched the COVID-19 vaccination program in March 2021, only 10% of the population received their two primary doses of vaccines by the end of May 2022. This delayed uptake of vaccines obviously warrants investigation. Therefore, we have conducted this study to evaluate the knowledge, attitude and acceptance of the general population in Sudan toward COVID-19 vaccines.\r\n\r\nA descriptive cross-sectional community-based study. The data were collected using an electronic questionnaire from 403 individuals living in Khartoum, Sudan. The data were processed using the Statistical Package for Social Sciences (SPSS), and data analysis was performed using appropriate tests.\r\n\r\n51% of the participants were found to have sufficient knowledge about the COVID-19 vaccine, and the knowledge level is higher among those educated beyond the secondary school and those who were employed. Among those unvaccinated, only 47% of the participants expressed their intention to take the vaccine when offered to them. The major reason for not trusting the vaccine is safety concerns expressed by 65.5% of the unvaccinated.\r\n\r\nHigher education levels and employment were associated with an increase in sufficient knowledge about the vaccine in around half of the participants. However, most of participants had not taken the vaccine at the time of the study, and the trust in vaccines is not high. Effective interventions by the health authorities are needed to address these issues in order to accelerate the COVID-19 vaccination program in Sudan.", "doi": "10.3934/publichealth.2023023", "pmid": "37304594", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10251048"}, {"db": "pii", "key": "publichealth-10-02-023"}], "notes": [], "created": "2023-10-04T09:31:41.409Z", "modified": "2023-10-04T10:52:10.669Z"}, {"entity": "publication", "iuid": "9a57591bcba24b9093ebed26803aed22", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9a57591bcba24b9093ebed26803aed22.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9a57591bcba24b9093ebed26803aed22"}}, "title": "Companion restrictions in the emergency department during COVID-19: physician perceptions from the Western Cape, South Africa.", "authors": [{"family": "Wiebe", "given": "Lauren E", "initials": "LE", "orcid": "0000-0003-3363-9735", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6559dcbb0024449e97fb89574e910f41.json"}}, {"family": "Alvesson", "given": "Helle Molsted", "initials": "HM"}, {"family": "Stassen", "given": "Willem", "initials": "W", "orcid": "0000-0002-1486-4446", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c751063bf7cf45dc887049c9554e2555.json"}}], "type": "journal article", "published": "2023-05-05", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "13", "issue": "5", "pages": "e070982"}, "abstract": "To determine emergency department (ED) physicians' perceptions regarding hospital companions being prohibited from accompanying the patient during COVID-19.\r\n\r\nTwo qualitative datasets were combined. Data collected included voice recordings, narrative interviewing and semistructured interviews. A reflexive thematic analysis was conducted and guided by the Normalisation Process Theory.\r\n\r\nSix hospital EDs in the Western Cape, South Africa.\r\n\r\nConvenience sampling was used to recruit a total of eight physicians working full time in the ED during COVID-19.\r\n\r\nThe lack of physical companions provided an opportunity for physicians to assess and reflect on a companion's role in efficient patient care. Physicians perceived that the COVID-19 restrictions illuminated that patient companions engaged in the ED as providers contributing to patient care by providing collateral information and patient support, while simultaneously engaging as consumers detracting physicians from their priorities and patient care. These restrictions prompted the physicians to consider how they understand their patients largely through the companions. When companions became virtual, the physicians were forced to shift how they perceive their patient, which included increased empathy.\r\n\r\nThe reflections of providers can feed into discussions about values within the healthcare system and can help explore the balance between medical and social safety, especially with companion restrictions still being practised in some hospitals. These perceptions illuminate various tradeoffs physicians had to consider throughout the pandemic and may be used to improve companion policies when planning for the continuation of the COVID-19 pandemic and future disease outbreaks.", "doi": "10.1136/bmjopen-2022-070982", "pmid": "37147101", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10163331"}, {"db": "pii", "key": "bmjopen-2022-070982"}], "notes": [], "created": "2023-10-04T05:10:34.020Z", "modified": "2023-10-04T06:45:49.656Z"}, {"entity": "publication", "iuid": "d9fdabb601214d838e8296641d250b76", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d9fdabb601214d838e8296641d250b76.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d9fdabb601214d838e8296641d250b76"}}, "title": "COVID vaccine evaluation of barriers and resources among families of children with diagnosed allergies.", "authors": [{"family": "Gooding", "given": "Gregory D", "initials": "GD"}, {"family": "Protudjer", "given": "Jennifer L", "initials": "JL"}, {"family": "Gabrielli", "given": "Sofianne", "initials": "S"}, {"family": "Mul\u00e9", "given": "Pasquale", "initials": "P"}, {"family": "Shand", "given": "Greg", "initials": "G"}, {"family": "Zhang", "given": "Xun", "initials": "X"}, {"family": "McCusker", "given": "Christine", "initials": "C"}, {"family": "Noya", "given": "Francisco J", "initials": "FJ"}, {"family": "Harvey", "given": "Maria", "initials": "M"}, {"family": "Chalifour", "given": "M\u00e9lodie", "initials": "M"}, {"family": "Sicard", "given": "Catherine", "initials": "C"}, {"family": "Abrams", "given": "Elissa", "initials": "E"}, {"family": "Amiel", "given": "Jacques-Alexandre", "initials": "J"}, {"family": "Ngo", "given": "Thanh-Thao", "initials": "T"}, {"family": "Bonnici", "given": "Andre", "initials": "A"}, {"family": "MacDonald", "given": "Noni", "initials": "N"}, {"family": "Ben-Shoshan", "given": "Moshe", "initials": "M"}], "type": "journal article", "published": "2023-05-05", "journal": {"title": "Front Allergy", "issn": "2673-6101", "issn-l": null, "volume": "4", "issue": null, "pages": "1101247"}, "abstract": "We aimed to determine vaccine hesitancy and the main barriers associated with the 2019 novel coronavirus, SARS-CoV-2 (COVID-19) vaccination among families of children diagnosed with food/drug/environmental allergies.\r\n\r\nBetween May and June 2021, we approached 146 families seen at the outpatient allergy clinic at the Montreal Children's Hospital and a community allergy practice were invited to complete an anonymous online survey on COVID-19 and vaccination attitudes and behaviour. Uni and multivariable logistic regressions were compared to estimate factors associated with vaccine hesitancy.\r\n\r\nAmong all patients, 24.1% reported vaccine hesitancy. The large majority of parents (95.2%) believed that vaccines work. The most common barrier to vaccination was fear of adverse side effects (57.0%). One-third of participants (31.5%) reported that a history of food, venom and drug allergy was a contraindication for COVID-19 vaccination. Fifty-nine (60.8%) participants stated that the dissemination of additional information would increase their willingness to be vaccinated. Most (96.9%) parents reported that their children's vaccinations were up to date. Hesitant families were more likely to be parents of children aged 6-10 years, be of Asian descent, report that mRNA vaccines are riskier than traditional vaccines, and report that the vaccine should not be given if the child has a history of allergic reaction to vaccines.\r\n\r\nVaccine hesitancy exists mainly among certain ethnic groups and families with young children. Allergies to food, venom and drug allergy are commonly perceived as contraindications for COVID-19 vaccination. Knowledge translation activities addressing parental concerns will help increase vaccination rates.", "doi": "10.3389/falgy.2023.1101247", "pmid": "37216150", "labels": {"Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10198258"}], "notes": [], "created": "2023-10-04T05:09:35.901Z", "modified": "2023-10-04T06:02:16.198Z"}, {"entity": "publication", "iuid": "27e3e8c68bd84f3c969c6cd81e935226", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27e3e8c68bd84f3c969c6cd81e935226.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27e3e8c68bd84f3c969c6cd81e935226"}}, "title": "Efficacy of the combination of monoclonal antibodies against the SARS-CoV-2 Beta and Delta variants.", "authors": [{"family": "Boonkrai", "given": "Chatikorn", "initials": "C"}, {"family": "Cotrone", "given": "Thomas S", "initials": "TS"}, {"family": "Chaisuriyong", "given": "Watchadaporn", "initials": "W"}, {"family": "Tantawichien", "given": "Terapong", "initials": "T"}, {"family": "Thisyakorn", "given": "Usa", "initials": "U"}, {"family": "Fernandez", "given": "Stefan", "initials": "S"}, {"family": "Hunsawong", "given": "Taweewun", "initials": "T"}, {"family": "Reed", "given": "Matthew", "initials": "M"}, {"family": "Wongtangprasert", "given": "Tossapon", "initials": "T"}, {"family": "Audomsun", "given": "Thittaya", "initials": "T"}, {"family": "Phakham", "given": "Tanapati", "initials": "T"}, {"family": "Attakitbancha", "given": "Chadaporn", "initials": "C"}, {"family": "Saelao", "given": "Pijitra", "initials": "P"}, {"family": "Focht", "given": "Dorota", "initials": "D"}, {"family": "Kimbung", "given": "Raymond", "initials": "R"}, {"family": "Welin", "given": "Martin", "initials": "M"}, {"family": "Malik", "given": "Aijaz Ahmad", "initials": "AA"}, {"family": "Pisitkun", "given": "Trairak", "initials": "T"}, {"family": "Srisawat", "given": "Nattachai", "initials": "N", "orcid": "0000-0002-8544-8132", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91b220be054242cd8f36efca9f2a70c8.json"}}], "type": "journal article", "published": "2023-05-04", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "18", "issue": "5", "pages": "e0284173"}, "abstract": "The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently the biggest healthcare issue worldwide. This study aimed to develop a monoclonal antibody against SARS-CoV-2 from B cells of recovered COVID-19 patients, which might have beneficial therapeutic purposes for COVID-19 patients. We successfully generated human monoclonal antibodies (hmAbs) against the receptor binding domain (RBD) protein of SARS-CoV-2 using developed hybridoma technology. The isolated hmAbs against the RBD protein (wild-type) showed high binding activity and neutralized the interaction between the RBD and the cellular receptor angiotensin-converting enzyme 2 (ACE2) protein. Epitope binning and crystallography results displayed target epitopes of these antibodies in distinct regions beneficial in the mix as a cocktail. The 3D2 binds to conserved epitopes among multi-variants. Pseudovirion-based neutralization results revealed that the antibody cocktail, 1D1 and 3D2, showed high potency in multiple variants of SARS-CoV-2 infection. In vivo studies showed the ability of the antibody cocktail treatment (intraperitoneal (i.p.) administration) to reduce viral load (Beta variant) in blood and various tissues. While the antibody cocktail treatment (intranasal (i.n.) administration) could not significantly reduce the viral load in nasal turbinate and lung tissue, it could reduce the viral load in blood, kidney, and brain tissue. These findings revealed that the efficacy of the antibody cocktail, 1D1 and 3D2, should be further studied in animal models in terms of timing of administration, optimal dose, and efficacy to mitigate inflammation in targeted tissue such as nasal turbinate and lung.", "doi": "10.1371/journal.pone.0284173", "pmid": "37141227", "labels": {"Category: Serology": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10159178"}, {"db": "pii", "key": "PONE-D-22-27378"}], "notes": [], "created": "2023-10-04T05:08:54.527Z", "modified": "2023-10-04T05:32:42.672Z"}, {"entity": "publication", "iuid": "a1b5dafaa42c438e84a08bf58d2bf8fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a1b5dafaa42c438e84a08bf58d2bf8fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a1b5dafaa42c438e84a08bf58d2bf8fa"}}, "title": "Occupational risk of COVID-19 in foreign-born employees in Denmark.", "authors": [{"family": "Bonde", "given": "J P E", "initials": "JPE", "orcid": "0000-0002-8181-3673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e986911aef045ab8b4b289094387930.json"}}, {"family": "Begtrup", "given": "L M", "initials": "LM"}, {"family": "Jensen", "given": "J H", "initials": "JH"}, {"family": "Flachs", "given": "E M", "initials": "EM"}, {"family": "Jakobsson", "given": "K", "initials": "K"}, {"family": "Nielsen", "given": "C", "initials": "C"}, {"family": "Nilsson", "given": "K", "initials": "K"}, {"family": "Rylander", "given": "L", "initials": "L", "orcid": "0000-0001-8288-8207", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8599a02e51843e8b8f484bc30b6addb.json"}}, {"family": "Vilhelmsson", "given": "A", "initials": "A"}, {"family": "Petersen", "given": "K U", "initials": "KU"}, {"family": "T\u00f8ttenborg", "given": "S S", "initials": "SS", "orcid": "0000-0001-7742-4360", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1e0c5d0c8e249478ce31daacec1d318.json"}}], "type": "journal article", "published": "2023-05-03", "journal": {"title": "Occup Med (Lond)", "issn": "1471-8405", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Foreign-born workers in high-income countries experience higher rates of COVID-19 but the causes are only partially known.\r\n\r\nTo examine if the occupational risk of COVID-19 in foreign-born workers deviates from the risk in native-born employees in Denmark.\r\n\r\nWithin a registry-based cohort of all residents employed in Denmark (n = 2 451 542), we identified four-digit DISCO-08 occupations associated with an increased incidence of COVID-19-related hospital admission during 2020-21 (at-risk occupations). The sex-specific prevalence of at-risk employment in foreign born was compared with the prevalence in native born. Moreover, we examined if the country of birth modified the risk of a positive SARS-CoV-2 polymerase chain reaction (PCR) test and COVID-19-related hospital admission in at-risk occupations.\r\n\r\nWorkers born in low-income countries and male workers from Eastern Europe more often worked in at-risk occupations (relative risks between 1.16 [95% confidence interval {CI} 1.14-1.17] and 1.87 [95% CI 1.82-1.90]). Being foreign-born modified the adjusted risk of PCR test positivity (test for interaction P < 0.0001), primarily because of higher risk in at-risk occupations among men born in Eastern European countries (incidence rate ratio [IRR] 2.39 [95% CI 2.09-2.72] versus IRR 1.19 [95% CI 1.14-1.23] in native-born men). For COVID-19-related hospital admission, no overall interaction was seen, and in women, country of birth did not consistently modify the occupational risk.\r\n\r\nWorkplace viral transmission may contribute to an excess risk of COVID-19 in male workers born in Eastern Europe, but most foreign-born employees in at-risk occupations seem not to be at higher occupational risk than native born.", "doi": "10.1093/occmed/kqad044", "pmid": "37133767", "labels": {"Category: Health": null, "Category: Social Science & Humanities": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7150760"}], "notes": [], "created": "2023-10-04T05:08:48.484Z", "modified": "2023-10-04T05:23:13.528Z"}, {"entity": "publication", "iuid": "13eb9e68408349a6b1eade757bfb16f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13eb9e68408349a6b1eade757bfb16f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13eb9e68408349a6b1eade757bfb16f9"}}, "title": "Association between SARS-CoV-2 vaccination and healthcare contacts for menstrual disturbance and bleeding in women before and after menopause: nationwide, register based cohort study.", "authors": [{"family": "Ljung", "given": "Rickard", "initials": "R", "orcid": "0000-0002-0654-4530", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ba40c2b98b1442192811ba44ffbf967.json"}}, {"family": "Xu", "given": "YiYi", "initials": "Y", "orcid": "0000-0001-9106-0049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06663aac11174e88a79cbb8e2ec4f3c0.json"}}, {"family": "Sundstr\u00f6m", "given": "Anders", "initials": "A", "orcid": "0000-0003-2337-3371", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5acbd5b816884f06807b23bd3e2e6cad.json"}}, {"family": "Leach", "given": "Susannah", "initials": "S", "orcid": "0000-0002-9614-2753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18d00be831d241dca238b3253d1b45f6.json"}}, {"family": "Hallberg", "given": "Ebba", "initials": "E"}, {"family": "Bygdell", "given": "Maria", "initials": "M", "orcid": "0000-0002-0737-8642", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8384a1c06034aff9aae842750462643.json"}}, {"family": "Larsson", "given": "Maria", "initials": "M"}, {"family": "Arthurson", "given": "Veronica", "initials": "V"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}, {"family": "Gedeborg", "given": "Rolf", "initials": "R", "orcid": "0000-0002-8850-7863", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/234ef51ed7854efb8bbadc3ce35bf7d9.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}], "type": "journal article", "published": "2023-05-03", "journal": {"title": "BMJ", "issn": "1756-1833", "issn-l": null, "volume": "381", "issue": null, "pages": "e074778"}, "abstract": "To evaluate the risks of any menstrual disturbance and bleeding following SARS-CoV-2 vaccination in women who are premenopausal or postmenopausal.\r\n\r\nA nationwide, register based cohort study.\r\n\r\nAll inpatient and specialised outpatient care in Sweden from 27 December 2020 to 28 February 2022. A subset covering primary care for 40% of the Swedish female population was also included.\r\n\r\n2 946 448 Swedish women aged 12-74 years were included. Pregnant women, women living in nursing homes, and women with history of any menstruation or bleeding disorders, breast cancer, cancer of female genital organs, or who underwent a hysterectomy between 1 January 2015 and 26 December 2020 were excluded.\r\n\r\nSARS-CoV-2 vaccination, by vaccine product (BNT162b2, mRNA-1273, or ChAdOx1 nCoV-19 (AZD1222)) and dose (unvaccinated and first, second, and third dose) over two time windows (one to seven days, considered the control period, and 8-90 days).\r\n\r\nHealthcare contact (admission to hospital or visit) for menstrual disturbance or bleeding before or after menopause (diagnosed with the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision codes N91, N92, N93, N95).\r\n\r\n2 580 007 (87.6%) of 2 946 448 women received at least one SARS-CoV-2 vaccination and 1 652 472 (64.0%) 2 580 007 of vaccinated women received three doses before the end of follow-up. The highest risks for bleeding in women who were postmenopausal were observed after the third dose, in the one to seven days risk window (hazard ratio 1.28 (95% confidence interval 1.01 to 1.62)) and in the 8-90 days risk window (1.25 (1.04 to 1.50)). The impact of adjustment for covariates was modest. Risk of postmenopausal bleeding suggested a 23-33% increased risk after 8-90 days with BNT162b2 and mRNA-1273 after the third dose, but the association with ChAdOx1 nCoV-19 was less clear. For menstrual disturbance or bleeding in women who were premenopausal, adjustment for covariates almost completely removed the weak associations noted in the crude analyses.\r\n\r\nWeak and inconsistent associations were observed between SARS-CoV-2 vaccination and healthcare contacts for bleeding in women who are postmenopausal, and even less evidence was recorded of an association for menstrual disturbance or bleeding in women who were premenopausal. These findings do not provide substantial support for a causal association between SARS-CoV-2 vaccination and healthcare contacts related to menstrual or bleeding disorders.", "doi": "10.1136/bmj-2023-074778", "pmid": "37137493", "labels": {"Category: Health": null, "Funder: VR": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10543813"}], "notes": [], "created": "2023-10-04T05:11:41.147Z", "modified": "2023-10-04T07:18:52.921Z"}, {"entity": "publication", "iuid": "5133ce1ea10e46caae5b032df6ab2b09", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5133ce1ea10e46caae5b032df6ab2b09.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5133ce1ea10e46caae5b032df6ab2b09"}}, "title": "Sociodemographic Factors and Adjustment of Daily Activities During the COVID-19 Pandemic - Findings from the SHARE Corona Survey.", "authors": [{"family": "Olofsson", "given": "Jenny", "initials": "J", "orcid": "0000-0003-0725-951X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed1a80c621ef48b18f45766cc29ce54c.json"}}, {"family": "Fors Connolly", "given": "Filip", "initials": "F", "orcid": "0000-0002-3857-4398", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2fbe2c1c98804f25a5e6c6fdde21fe03.json"}}, {"family": "Malmberg", "given": "Gunnar", "initials": "G", "orcid": "0000-0003-0531-2743", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/efd0e5c960f04373a96ea862b4072b9d.json"}}, {"family": "Josefsson", "given": "Maria", "initials": "M", "orcid": "0000-0002-1812-3581", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b119b08d9787455894f5ee784f0805e5.json"}}, {"family": "Stattin", "given": "Mikael", "initials": "M", "orcid": "0000-0003-0817-0576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9679f7d8f5c8410d83103fcf7d88fe8e.json"}}], "type": "journal article", "published": "2023-05-01", "journal": {"title": "J Aging Soc Policy", "issn": "1545-0821", "issn-l": null, "volume": null, "issue": null, "pages": "1-23"}, "abstract": "In the wake of the COVID-19 pandemic in 2020, older people across Europe have adjusted their daily activities as personal risk avoidance and as an amendment to policy recommendations and restrictions. In this study, we use multilevel logistic regressions to examine to what extent sociodemographic factors are associated with activity reduction among the older population (50+) in Europe and whether these associations are moderated by governmental policy responses to COVID-19. By combining data for~35,000 respondents from the SHARE Corona Survey on reported changes in daily activities and stringency of restrictions at the national level, we find that older age, poorer health and being female versus male were (consistently) associated with greater activity reduction across all activities both in countries with weak and in those with strong restrictions. Associations between education, employment and living situation, on the one hand, and activity reduction, on the other, were weaker and less consistent. We conclude that differences between sociodemographic groups are rather similar for countries with weak and those with strong restrictions and hence argue that group-specific policy recommendation are relevant independent of stringency recommendations.", "doi": "10.1080/08959420.2023.2206077", "pmid": "37125862", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:10:47.974Z", "modified": "2023-10-04T06:58:45.924Z"}, {"entity": "publication", "iuid": "7fdb5107e7e6410682607672a304c086", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7fdb5107e7e6410682607672a304c086.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7fdb5107e7e6410682607672a304c086"}}, "title": "Transition from physical to online shopping alternatives due to the COVID-19 pandemic - A case study of Italy and Sweden.", "authors": [{"family": "Andruetto", "given": "Claudia", "initials": "C"}, {"family": "Bin", "given": "Elisa", "initials": "E"}, {"family": "Susilo", "given": "Yusak", "initials": "Y"}, {"family": "Pernest\u00e5l", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "Transp Res Part A Policy Pract", "issn": "0965-8564", "volume": "171", "pages": "103644", "issn-l": null}, "abstract": "Using 530 responses from an online questionnaire, this study aims to investigate the transition from physical to online shopping alternatives during the first wave of the COVID-19 pandemic at the individual level. The focus areas of the study are Sweden and Italy, two European countries that implemented contrasting prevention measures. This study analyses the impacts of the pandemic on the transition to online shopping activities, and identifies who among the respondents changed their shopping behaviour the most and how; and what the different shopping strategies are and who adopted them. Multivariate statistical analyses, including linear and binary logistic regressions and multinomial logit models, were used to analyse the dataset. In the analysis, the dataset was split between Italy and Sweden to take into account the contrasting prevention measures and the different social and economic backgrounds of the two countries; the results of this study confirm and highlight these differences. Moreover, the socio-demographic and household structures of the respondents were found to influence the amount and the direction of change in shopping behaviour during the first wave of the pandemic. The study also indicates some policies that can be implemented and/or further strengthened to increase the resilience of citizens in facing pandemics and to derive benefit from the behavioural changes that took place during the first wave of the pandemic.", "doi": "10.1016/j.tra.2023.103644", "pmid": "36960356", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10008802"}, {"db": "pii", "key": "S0965-8564(23)00064-2"}], "notes": [], "created": "2023-04-21T16:04:23.892Z", "modified": "2023-04-21T16:04:23.911Z"}, {"entity": "publication", "iuid": "6a85486d50604effabbb6b75db7a7082", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a85486d50604effabbb6b75db7a7082.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a85486d50604effabbb6b75db7a7082"}}, "title": "Segregation and the pandemic: The dynamics of daytime social diversity during COVID-19 in Greater Stockholm.", "authors": [{"family": "M\u00fc\u00fcrisepp", "given": "Kerli", "initials": "K"}, {"family": "J\u00e4rv", "given": "Olle", "initials": "O"}, {"family": "Sj\u00f6blom", "given": "Feliks", "initials": "F"}, {"family": "Toger", "given": "Marina", "initials": "M"}, {"family": "\u00d6sth", "given": "John", "initials": "J"}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "Appl Geogr", "issn": "0143-6228", "volume": "154", "pages": "102926", "issn-l": null}, "abstract": "In this study, we set out to understand how the changes in daily mobility of people during the first wave of the COVID-19 pandemic in spring 2020 influenced daytime spatial segregation. Rather than focusing on spatial separation, we approached this task from the perspective of daytime socio-spatial diversity - the degree to which people from socially different neighbourhoods share urban space during the day. By applying mobile phone data from Greater Stockholm, Sweden, the study examines weekly changes in 1) daytime social diversity across different types of neighbourhoods, and 2) population groups' exposure to diversity in their main daytime activity locations. Our findings show a decline in daytime diversity in neighbourhoods when the pandemic broke out in mid-March 2020. The decrease in diversity was marked in urban centres, and significantly different in neighbourhoods with different socio-economic and ethnic compositions. Moreover, the decrease in people's exposure to diversity in their daytime activity locations was even more profound and long-lasting. In particular, isolation from diversity increased more among residents of high-income majority neighbourhoods than of low-income minority neighbourhoods. We conclude that while some COVID-19-induced changes might have been temporary, the increased flexibility in where people work and live might ultimately reinforce both residential and daytime segregation.", "doi": "10.1016/j.apgeog.2023.102926", "pmid": "36999002", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC9998301"}, {"db": "pii", "key": "S0143-6228(23)00057-7"}], "notes": [], "created": "2023-04-21T15:50:37.167Z", "modified": "2023-04-21T15:50:59.427Z"}, {"entity": "publication", "iuid": "ca29acd5924d4774918cb18f04a947aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ca29acd5924d4774918cb18f04a947aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ca29acd5924d4774918cb18f04a947aa"}}, "title": "Pre- and post-vaccination characteristics and risk factors for COVID-19 outcomes in a Swedish population-based cohort of COPD patients.", "authors": [{"family": "Kirui", "given": "Brian K", "initials": "BK"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW", "orcid": "0000-0002-4387-4096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bb5d1f761ef48c4837ed4f984717f0e.json"}}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Franz\u00e9n", "given": "Stefan", "initials": "S", "orcid": "0000-0001-6622-3838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e2fc66fb68748eba5a7f8eb93c5ff3f.json"}}, {"family": "Stridsman", "given": "Caroline", "initials": "C", "orcid": "0000-0001-6622-3838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e2fc66fb68748eba5a7f8eb93c5ff3f.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "ERJ Open Res", "issn": "2312-0541", "issn-l": null, "volume": "9", "issue": "3", "pages": null}, "abstract": "Evidence on risk factors for Coronavirus disease 2019 (COVID-19) outcomes among patients with COPD in relation to COVID-19 vaccination remains limited. The objectives of the present study were to characterise determinants of COVID-19 infection, hospitalisation, intensive care unit (ICU) admission and death in COPD patients in their unvaccinated state compared to when vaccinated.\r\n\r\nWe included all COPD patients in the Swedish National Airway Register (SNAR). Events of COVID-19 infection (test and/or healthcare encounter), hospitalisation, ICU admission and death were identified from 1 January 2020 to 30 November 2021. Using adjusted Cox regression, associations between baseline sociodemographics, comorbidities, treatments, clinical measurements and COVID-19 outcomes, during unvaccinated and vaccinated follow-up time, were analysed.\r\n\r\nThe population-based COPD cohort included 87 472 patients, among whom 6771 (7.7%) COVID-19 infections, 2897 (3.3%) hospitalisations, 233 (0.3%) ICU admissions and 882 (1.0%) COVID-19 deaths occurred. During unvaccinated follow-up, risk of COVID-19 hospitalisation and death increased with age, male sex, lower education, non-married status and being foreign-born. Comorbidities increased risk of several outcomes, e.g. respiratory failure for infection and hospitalisation (adjusted hazard ratios (HR) 1.78, 95% CI 1.58-2.02 and 2.51, 2.16-2.91, respectively), obesity for ICU admission (3.52, 2.29-5.40) and cardiovascular disease for mortality (2.80, 2.16-3.64). Inhaled COPD therapy was associated with infection, hospitalisation and death. COPD severity was also associated with COVID-19, especially hospitalisation and death. Although the risk factor panorama was similar, COVID-19 vaccination attenuated HRs for some risk factors.\r\n\r\nThis study provides population-based evidence on predictive risk factors for COVID-19 outcomes and highlights the positive implications of COVID-19 vaccination for COPD patients.", "doi": "10.1183/23120541.00711-2022", "pmid": "37377661", "labels": {"Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10291311"}, {"db": "pii", "key": "00711-2022"}], "notes": [], "created": "2023-10-04T09:30:36.503Z", "modified": "2023-10-04T09:59:26.297Z"}, {"entity": "publication", "iuid": "757f413ea2304a4aac07ae5416a34990", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/757f413ea2304a4aac07ae5416a34990.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/757f413ea2304a4aac07ae5416a34990"}}, "title": "Microneedle Patch for Painless Intradermal Collection of Interstitial Fluid Enabling Multianalyte Measurement of Small Molecules, SARS-CoV-2 Antibodies, and Protein Profiling.", "authors": [{"family": "Ribet", "given": "Federico", "initials": "F", "orcid": "0000-0002-3549-0228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70e482c3c2454cb0924540e41bd5eb72.json"}}, {"family": "Bendes", "given": "Annika", "initials": "A"}, {"family": "Fredolini", "given": "Claudia", "initials": "C"}, {"family": "Dobielewski", "given": "Mikolaj", "initials": "M"}, {"family": "B\u00f6ttcher", "given": "Michael", "initials": "M"}, {"family": "Beck", "given": "Olof", "initials": "O"}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM"}, {"family": "Stemme", "given": "G\u00f6ran", "initials": "G"}, {"family": "Roxhed", "given": "Niclas", "initials": "N"}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "Adv Healthc Mater", "issn": "2192-2659", "issn-l": null, "volume": "12", "issue": "13", "pages": "e2202564"}, "abstract": "Blood sampling is a common practice to monitor health, but it entails a series of drawbacks for patients including pain and discomfort. Thus, there is a demand for more convenient ways to obtain samples. Modern analytical techniques enable monitoring of multiple bioanalytes in smaller samples, opening possibilities for new matrices, and microsampling technologies to be adopted. Interstitial fluid (ISF) is an attractive alternative matrix that shows good correlation with plasma concentration dynamics for several analytes and can be sampled in a minimally invasive and painless manner from the skin at the point-of-care. However, there is currently a lack of sampling devices compatible with clinical translation. Here, to tackle state-of-the-art limitations, a cost-effective and compact single-microneedle-based device designed to painlessly collect precisely 1.1 \u00b5L of dermal ISF within minutes is presented. The fluid is volume-metered, dried, and stably stored into analytical-grade paper within the microfluidic device. The obtained sample can be mailed to a laboratory, quantitatively analyzed, and provide molecular insights comparable to blood testing. In a human study, the possibility to monitor various classes of molecular analytes is demonstrated in ISF microsamples, including caffeine, hundreds of proteins, and SARS-CoV-2 antibodies, some being detected in ISF for the first time.", "doi": "10.1002/adhm.202202564", "pmid": "36748807", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Funder: H2020": null}, "xrefs": [{"db": "URL", "key": "https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fadhm.202202564&file=adhm202202564-sup-0001-SuppMat.pdf", "description": "https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fadhm.202202564&file=adhm202202564-sup-0001-SuppMat.pdf"}], "notes": [], "created": "2023-02-13T17:56:35.394Z", "modified": "2023-06-19T14:19:26.937Z"}, {"entity": "publication", "iuid": "97df576b98e6430cbe84455e52197b3a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/97df576b98e6430cbe84455e52197b3a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/97df576b98e6430cbe84455e52197b3a"}}, "title": "Insight into vaccination and meteorological factors on daily COVID-19 cases and mortality in Bangladesh.", "authors": [{"family": "Hasan", "given": "Mohammad Nayeem", "initials": "MN"}, {"family": "Islam", "given": "Md Aminul", "initials": "MA"}, {"family": "Sangkham", "given": "Sarawut", "initials": "S"}, {"family": "Werkneh", "given": "Adhena Ayaliew", "initials": "AA"}, {"family": "Hossen", "given": "Foysal", "initials": "F"}, {"family": "Haque", "given": "Md Atiqul", "initials": "MA"}, {"family": "Alam", "given": "Mohammad Morshad", "initials": "MM"}, {"family": "Rahman", "given": "Md Arifur", "initials": "MA"}, {"family": "Mukharjee", "given": "Sanjoy Kumar", "initials": "SK"}, {"family": "Chowdhury", "given": "Tahmid Anam", "initials": "TA"}, {"family": "Sosa-Hern\u00e1ndez", "given": "Juan Eduardo", "initials": "JE"}, {"family": "Jakariya", "given": "Md", "initials": "M"}, {"family": "Ahmed", "given": "Firoz", "initials": "F"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Sarkodie", "given": "Samuel Asumadu", "initials": "SA"}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "Groundw Sustain Dev", "issn": "2352-801X", "volume": "21", "pages": "100932", "issn-l": null}, "abstract": "The ongoing COVID-19 contagious disease caused by SARS-CoV-2 has disrupted global public health, businesses, and economies due to widespread infection, with 676.41 million confirmed cases and 6.77 million deaths in 231 countries as of February 07, 2023. To control the rapid spread of SARS-CoV-2, it is crucial to determine the potential determinants such as meteorological factors and their roles. This study examines how COVID-19 cases and deaths changed over time while assessing meteorological characteristics that could impact these disparities from the onset of the pandemic. We used data spanning two years across all eight administrative divisions, this is the first of its kind--showing a connection between meteorological conditions, vaccination, and COVID-19 incidences in Bangladesh. We further employed several techniques including Simple Exponential Smoothing (SES), Auto-Regressive Integrated Moving Average (ARIMA), Auto-Regressive Integrated Moving Average with explanatory variables (ARIMAX), and Automatic forecasting time-series model (Prophet). We further analyzed the effects of COVID-19 vaccination on daily cases and deaths. Data on COVID-19 cases collected include eight administrative divisions of Bangladesh spanning March 8, 2020, to January 31, 2023, from available online servers. The meteorological data include rainfall (mm), relative humidity (%), average temperature (\u00b0C), surface pressure (kPa), dew point (\u00b0C), and maximum wind speed (m/s). The observed wind speed and surface pressure show a significant negative impact on COVID-19 cases (-0.89, 95% confidence interval (CI): 1.62 to -0.21) and (-1.31, 95%CI: 2.32 to -0.29), respectively. Similarly, the observed wind speed and surface pressure show a significant negative impact on COVID-19 deaths (-0.87, 95% CI: 1.54 to -0.21) and (-3.11, 95%CI: 4.44 to -1.25), respectively. The impact of meteorological factors is almost similar when vaccination information is included in the model. However, the impact of vaccination in both cases and deaths model is significantly negative (for cases: 1.19, 95%CI: 2.35 to -0.38 and for deaths: 1.55, 95%CI: 2.88 to -0.43). Accordingly, vaccination effectively reduces the number of new COVID-19 cases and fatalities in Bangladesh. Thus, these results could assist future researchers and policymakers in the assessment of pandemics, by making thorough efforts that account for COVID-19 vaccinations and meteorological conditions.", "doi": "10.1016/j.gsd.2023.100932", "pmid": "36945723", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9977696"}, {"db": "pii", "key": "S2352-801X(23)00032-2"}], "notes": [], "created": "2023-04-21T16:07:26.169Z", "modified": "2023-04-21T16:07:26.184Z"}, {"entity": "publication", "iuid": "18e6b93c9ab24c4f91ca0341366a0aae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18e6b93c9ab24c4f91ca0341366a0aae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18e6b93c9ab24c4f91ca0341366a0aae"}}, "title": "Ambient air pollution exposure linked to long COVID among young adults: a nested survey in a population-based cohort in Sweden.", "authors": [{"family": "Yu", "given": "Zhebin", "initials": "Z"}, {"family": "Ekstr\u00f6m", "given": "Sandra", "initials": "S"}, {"family": "Bellander", "given": "Tom", "initials": "T"}, {"family": "Ljungman", "given": "Petter", "initials": "P"}, {"family": "Pershagen", "given": "G\u00f6ran", "initials": "G"}, {"family": "Eneroth", "given": "Kristina", "initials": "K"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "Bergstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Georgelis", "given": "Antonios", "initials": "A"}, {"family": "Stafoggia", "given": "Massimo", "initials": "M"}, {"family": "Gruzieva", "given": "Olena", "initials": "O"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "BAMSE COVID-19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "issn-l": null, "volume": "28", "issue": null, "pages": "100608"}, "abstract": "Post COVID-19 conditions, also known as long COVID, are of public health concern, but little is known about their underlying risk factors. We aimed to investigate associations of air pollution exposure with long COVID among Swedish young adults.\r\n\r\nWe used data from the BAMSE (Children, Allergy, Environment, Stockholm, Epidemiology [in Swedish]) cohort. From October 2021 to February 2022 participants answered a web-questionnaire focusing on persistent symptoms following acute SARS-CoV-2 infection. Long COVID was defined as symptoms after confirmed infection with SARS-CoV-2 lasting for two months or longer. Ambient air pollution levels (particulate matter \u22642.5 \u03bcm [PM2.5], \u226410 \u03bcm [PM10], black carbon [BC] and nitrogen oxides [NOx]) at individual-level addresses were estimated using dispersion modelling.\r\n\r\nA total of 753 participants with SARS-CoV-2 infection were included of whom 116 (15.4%) reported having long COVID. The most common symptoms were altered smell/taste (n = 80, 10.6%), dyspnea (n = 36, 4.8%) and fatigue (n = 34, 4.5%). Median annual PM2.5 exposure in 2019 (pre-pandemic) was 6.39 (interquartile range [IQR] 6.06-6.71) \u03bcg/m3. Adjusted Odds Ratios (95% confidence intervals) of PM2.5 per IQR increase were 1.28 (1.02-1.60) for long COVID, 1.65 (1.09-2.50) for dyspnea symptoms and 1.29 (0.97-1.70) for altered smell/taste. Positive associations were found for the other air pollutants and remained consistent across sensitivity analyses. Associations tended to be stronger among participants with asthma, and those having had COVID during 2020 (versus 2021).\r\n\r\nAmbient long-term PM2.5 exposure may affect the risk of long COVID in young adults, supporting efforts for continuously improving air quality.\r\n\r\nThe study received funding from the Swedish Research Council (grant no. 2020-01886, 2022-06340), the Swedish Research Council for Health, Working life and Welfare (FORTE grant no. 2017-01146), the Swedish Heart-Lung Foundation, Karolinska Institute (no. 2022-01807) and Region Stockholm (ALF project for cohort and database maintenance).", "doi": "10.1016/j.lanepe.2023.100608", "pmid": "37131862", "labels": {"Category: Post-COVID": null, "Funder: VR": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9989696"}, {"db": "pii", "key": "S2666-7762(23)00026-1"}], "notes": [], "created": "2023-10-04T05:10:14.692Z", "modified": "2023-10-04T06:31:11.088Z"}, {"entity": "publication", "iuid": "e2c251d61bc24c6ba1f59716f2af86f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2c251d61bc24c6ba1f59716f2af86f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2c251d61bc24c6ba1f59716f2af86f8"}}, "title": "Lessons learnt during COVID-19: making sense of Australian and Swedish university lecturers' experience.", "authors": [{"family": "Turner", "given": "Kristina", "initials": "K", "orcid": "0000-0002-0585-9207", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43081e9e652c4bd7a7a06d3289a5968c.json"}}, {"family": "O'Brien", "given": "Siobhan", "initials": "S"}, {"family": "Wallstr\u00f6m", "given": "Helena", "initials": "H"}, {"family": "Samuelsson", "given": "Katarina", "initials": "K"}, {"family": "Uusim\u00e4ki", "given": "Sirkka-Liisa Marjatta", "initials": "SM"}], "type": "journal article", "published": "2023-04-28", "journal": {"title": "Int J Educ Technol High Educ", "issn": "2365-9440", "issn-l": null, "volume": "20", "issue": "1", "pages": "25"}, "abstract": "This article reports on a study analysing changes in the use of digital technologies and working from home during the COVID-19 crisis and the impact of these changes on the wellbeing of five female university lecturers from Australia and Sweden. Applying collaborative autoethnographical methods, this study employed Weick's sensemaking framework to explore how the academics made sense of these sudden changes. The Positive emotion, Engagement, Relationships, Meaning, and Accomplishment (PERMA) wellbeing framework was also employed to explore the effect of these changes on the academics' wellbeing. Findings from the reflective narratives show that after the initial experiences of stress, each university lecturer was able to adapt and navigate the online teaching environment during the pandemic. However, the time constraints in preparing and adapting to online teaching, and working from home, were experienced by some of the university lecturers as highly stressful and isolating which impacted their sense of wellbeing. Even so, working from home was recognized as a positive experience, providing time for research, hobbies, and time with family. This study addresses a gap in current knowledge by examining the impact of the sudden transition to online teaching and learning had on academic wellbeing as conceptualised through the PERMA framework. In addition, by applying Weick's sensemaking framework, this study provides a unique perspective around how academics made sense of the sudden switch to online teaching and learning during COVID-19.", "doi": "10.1186/s41239-023-00395-5", "pmid": "37131502", "labels": {"Category: Social Science & Humanities": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10139830"}, {"db": "pii", "key": "395"}], "notes": [], "created": "2023-10-04T05:11:08.068Z", "modified": "2023-10-04T07:07:32.243Z"}, {"entity": "publication", "iuid": "f85426a33bd547b5b2d964cd3f37287a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f85426a33bd547b5b2d964cd3f37287a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f85426a33bd547b5b2d964cd3f37287a"}}, "title": "Physical functioning post-COVID-19 and the recovery process: a mixed methods study.", "authors": [{"family": "Tofiq", "given": "Avin", "initials": "A", "orcid": "0000-0003-1712-7510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1460dc1501cf4a599430688991f6139f.json"}}, {"family": "Eriksson Crommert", "given": "Martin", "initials": "M"}, {"family": "Zakrisson", "given": "Ann-Britt", "initials": "AB", "orcid": "0000-0002-8370-8834", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc03287b22de4d27bb5d594b7e4ac7f3.json"}}, {"family": "von Euler", "given": "Mia", "initials": "M"}, {"family": "Nilsing Strid", "given": "Emma", "initials": "E", "orcid": "0000-0002-0483-8981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6022f01a844440ea4ca64f114b47058.json"}}], "type": "journal article", "published": "2023-04-20", "journal": {"title": "Disabil Rehabil", "issn": "1464-5165", "pages": "1-10", "issn-l": null}, "abstract": "To describe physical functioning after severe COVID-19-infection.\n\nAn explanatory sequential mixed method design was used. Thirty-nine participants performed tests and answered questionnaires measuring physical functioning six months after hospitalisation due to COVID-19. Thirty of these participants participated in semi-structured interviews with questions regarding how they perceived their physical functioning and recovery from COVID-19 at 12 months post-hospitalisation.\n\nAt six months, physical functioning measured via chair stand test and hip-worn accelerometers was lower than normal reference values. There was a reduction in breathing muscle strength. Participants estimated their functional status during different activities as lower compared to those before COVID-19-infection, measured with a patient-specific functional scale. At one year after infection, there were descriptions of a rough recovery process and remaining symptoms.\n\nPatients recovering from severe COVID-19 seem to have reduced physical functioning and activity levels, and they perceive their recovery to be slow and difficult. They experienced a lack of clinical support and contradictory advice regarding rehabilitation. Coaching in returning to physical functioning after the infection needs to be better co-ordinated and there is a need for guidelines for health professionals to avoid patients receiving contradictory advice.", "doi": "10.1080/09638288.2023.2201512", "pmid": "37078388", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [], "notes": [], "created": "2023-04-20T17:18:25.671Z", "modified": "2023-04-20T17:18:25.834Z"}, {"entity": "publication", "iuid": "355f4f39a9d045f09a4a8f7b1b5a5114", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/355f4f39a9d045f09a4a8f7b1b5a5114.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/355f4f39a9d045f09a4a8f7b1b5a5114"}}, "title": "Impairment of quality of life due to COVID-19-induced long-term olfactory dysfunction.", "authors": [{"family": "Winter", "given": "Anja L", "initials": "AL"}, {"family": "Henecke", "given": "Sofie", "initials": "S"}, {"family": "Lundstr\u00f6m", "given": "Johan N", "initials": "JN"}, {"family": "Thunell", "given": "Evelina", "initials": "E"}], "type": "journal article", "published": "2023-04-20", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "14", "issue": null, "pages": "1165911"}, "abstract": "Olfactory dysfunction is one of many long-lasting symptoms associated with COVID-19, estimated to affect approximately 60% of individuals and often lasting several months after infection. The associated daily life problems can cause a decreased quality of life.\r\n\r\nHere, we assessed the association between perceived quality of life and both qualitative and quantitative olfactory function (distorted and weakened sense of smell, respectively) in 58 individuals who had undergone confirmed SARS-CoV-2 infection and who complained about olfactory dysfunction.\r\n\r\nParticipants with large quantitative olfactory dysfunction experienced a greater reduction in their quality of life. Moreover, our participants had a high prevalence of qualitative olfactory dysfunction (81%) with a significant correlation between qualitative olfactory dysfunction and daily life impairment. Strong drivers of low quality of life assessments were lack of enjoyment of food as well as worries related to coping with long-term dysfunctions.\r\n\r\nThese results stress the clinical importance of assessing qualitative olfactory dysfunction and the need to develop relevant interventions. Given the poor self-rated quality of life observed, healthcare systems should consider developing support structures, dietary advice, and guidelines adapted to individuals experiencing qualitative olfactory dysfunction.", "doi": "10.3389/fpsyg.2023.1165911", "pmid": "37151341", "labels": {"Category: Post-COVID": null, "Funder: VR": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC10157159"}], "notes": [], "created": "2023-10-04T05:10:26.106Z", "modified": "2023-10-04T06:38:09.971Z"}, {"entity": "publication", "iuid": "a238c04e9e0549458fbbb0ef9cb9d776", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a238c04e9e0549458fbbb0ef9cb9d776.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a238c04e9e0549458fbbb0ef9cb9d776"}}, "title": "Self-care behaviours of patients with left ventricular assist devices in Israel: changes during the COVID-19 pandemic.", "authors": [{"family": "Melnikov", "given": "Semyon", "initials": "S"}, {"family": "Ben Avraham", "given": "Binyamin", "initials": "B"}, {"family": "Itzhaki Ben Zadok", "given": "Osnat", "initials": "O"}, {"family": "Shaul", "given": "Aviv", "initials": "A"}, {"family": "Abuhazira", "given": "Miri", "initials": "M"}, {"family": "Yaari", "given": "Vicky", "initials": "V"}, {"family": "Jaarsma", "given": "Tiny", "initials": "T"}, {"family": "Ben-Gal", "given": "Tuvia", "initials": "T"}], "type": "journal article", "published": "2023-04-19", "journal": {"title": "ESC Heart Fail", "issn": "2055-5822", "issn-l": null}, "abstract": "Left ventricular assist devices (LVADs) support the hearts of patients with advanced heart failure. Following LVAD implantation, patients face a complex regimen of self-care behaviours including self-care maintenance, self-care monitoring and self-care management. However, during the COVID-19 pandemic, symptoms of anxiety and depression may have interfered with their self-care. Currently, little is known on how specific self-care behaviours of LVAD-implanted patients changed during the COVID-19 pandemic. We aim to describe the changes in self-care behaviours among patients with an implanted LVAD in Israel during the COVID-19 pandemic and explore the factors related to self-care behaviour change.\n\nA prospective observational cross-sectional study design. A convenience sample of 27 Israeli LVAD-implanted patients (mean age 62.4 \u00b1 9, 86% male, 78.6% living with a partner) completed the LVAD Self-Care Behaviour Scale (1 = never to 5 = always) and Hospital Anxiety and Depression Scale (0 = not at all to 3 = most of the time). Data were collected before and after the onset of the COVID-19 pandemic in Israel. Statistical analyses included paired t-tests, Pearson's correlations, and one-way repeated measures ANOVAs.\n\nDuring the COVID-19 pandemic, a significant decrease was found in patients' adherence to checking and recording their LVAD speed, flow, power and PI (Pulsatility Index) (P = 0.05), checking their INR (P = 0.01), and daily weighing (P < 0.01). The prevalence of some behaviours (e.g. regularly exercising) increased in some patients and decreased in others. Patients living without a partner worsened their adherence to some of the self-care behaviours (e.g. taking medicines as prescribed), compared with those living with a partner (Mb = 5.0 \u00b1 0 and Md = 5.0 \u00b1 0, delta = 0 vs. Mb = 5.0 \u00b1 0 and Md = 4.6 \u00b1 0.9, delta = -0.4, respectively; F = 4.9, P = 0.04). Women, and not men, tended to improve their adherence to the self-care behaviour such as avoiding kinking, pulling, or moving the LVAD driveline at the exit site (Mb = 4.0 \u00b1 1.0 and Md = 5.0 \u00b1 0, delta = 1.0 vs. Mb = 4.5 \u00b1 0.9 and Md = 4.4 \u00b1 1.2, delta = -0.1, F = 4.7, P = 0.04, respectively). In total, 41% (11) patients reported neither anxiety nor depression, 11% (3) reported anxiety, 15% (4) reported depression, and 44% (12) reported both anxiety and depression. No associations between anxiety and/or depression and self-care behaviours were found.\n\nPriorities in self-care behaviours among patients with implanted LVAD changed after the onset of the COVID-19 pandemic. Factors that assisted with adherence to self-care behaviours included living with a partner and being female. The current results may guide further research on identifying behaviours that are at risk of not being maintained during a time of emergency.", "doi": "10.1002/ehf2.14376", "pmid": "37075748", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-20T17:20:14.850Z", "modified": "2023-04-20T17:20:14.854Z"}, {"entity": "publication", "iuid": "8a5bbed2693e49ad9287f37d8e9ffe0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a5bbed2693e49ad9287f37d8e9ffe0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a5bbed2693e49ad9287f37d8e9ffe0e"}}, "title": "The role of booster vaccination in decreasing COVID-19 age-adjusted case fatality rate: Evidence from 32 countries.", "authors": [{"family": "Zhou", "given": "Cui", "initials": "C"}, {"family": "Wheelock", "given": "\u00c5sa M", "initials": "\u00c5M"}, {"family": "Zhang", "given": "Chutian", "initials": "C"}, {"family": "Ma", "given": "Jian", "initials": "J"}, {"family": "Dong", "given": "Kaixing", "initials": "K"}, {"family": "Pan", "given": "Jingxiang", "initials": "J"}, {"family": "Li", "given": "Zhichao", "initials": "Z"}, {"family": "Liang", "given": "Wannian", "initials": "W"}, {"family": "Gao", "given": "Jing", "initials": "J"}, {"family": "Xu", "given": "Lei", "initials": "L"}], "type": "journal article", "published": "2023-04-18", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "11", "issue": null, "pages": "1150095"}, "abstract": "The global COVID-19 pandemic is still ongoing, and cross-country and cross-period variation in COVID-19 age-adjusted case fatality rates (CFRs) has not been clarified. Here, we aimed to identify the country-specific effects of booster vaccination and other features that may affect heterogeneity in age-adjusted CFRs with a worldwide scope, and to predict the benefit of increasing booster vaccination rate on future CFR.\r\n\r\nCross-temporal and cross-country variations in CFR were identified in 32 countries using the latest available database, with multi-feature (vaccination coverage, demographic characteristics, disease burden, behavioral risks, environmental risks, health services and trust) using Extreme Gradient Boosting (XGBoost) algorithm and SHapley Additive exPlanations (SHAP). After that, country-specific risk features that affect age-adjusted CFRs were identified. The benefit of booster on age-adjusted CFR was simulated by increasing booster vaccination by 1-30% in each country.\r\n\r\nOverall COVID-19 age-adjusted CFRs across 32 countries ranged from 110 deaths per 100,000 cases to 5,112 deaths per 100,000 cases from February 4, 2020 to Jan 31, 2022, which were divided into countries with age-adjusted CFRs higher than the crude CFRs and countries with age-adjusted CFRs lower than the crude CFRs (n = 9 and n = 23) when compared with the crude CFR. The effect of booster vaccination on age-adjusted CFRs becomes more important from Alpha to Omicron period (importance scores: 0.03-0.23). The Omicron period model showed that the key risk factors for countries with higher age-adjusted CFR than crude CFR are low GDP per capita and low booster vaccination rates, while the key risk factors for countries with higher age-adjusted CFR than crude CFR were high dietary risks and low physical activity. Increasing booster vaccination rates by 7% would reduce CFRs in all countries with age-adjusted CFRs higher than the crude CFRs.\r\n\r\nBooster vaccination still plays an important role in reducing age-adjusted CFRs, while there are multidimensional concurrent risk factors and precise joint intervention strategies and preparations based on country-specific risks are also essential.", "doi": "10.3389/fpubh.2023.1150095", "pmid": "37143970", "labels": {"Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10151823"}], "notes": [], "created": "2023-10-04T05:12:06.882Z", "modified": "2023-10-04T07:28:47.537Z"}, {"entity": "publication", "iuid": "45834f0045954b6280dea027a997784b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/45834f0045954b6280dea027a997784b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/45834f0045954b6280dea027a997784b"}}, "title": "Plasmablasts in previously immunologically na\u00efve COVID-19 patients express markers indicating mucosal homing and secrete antibodies cross-reacting with SARS-CoV-2 variants and other beta-coronaviruses.", "authors": [{"family": "Lundgren", "given": "Anna", "initials": "A"}, {"family": "Leach", "given": "Susannah", "initials": "S", "orcid": "0000-0002-9614-2753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18d00be831d241dca238b3253d1b45f6.json"}}, {"family": "Axelsson", "given": "Hannes", "initials": "H"}, {"family": "Isakson", "given": "Pauline", "initials": "P"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Scharf", "given": "Lydia", "initials": "L"}, {"family": "Andersson", "given": "Bengt A", "initials": "BA"}, {"family": "Miron", "given": "Nicolae", "initials": "N"}, {"family": "Marklund", "given": "Emelie", "initials": "E"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Gisslen", "given": "Magnus", "initials": "M"}, {"family": "Angeletti", "given": "Davide", "initials": "D"}, {"family": "Bemark", "given": "Mats", "initials": "M", "orcid": "0000-0001-7416-9819", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ae923943b6c4b4bb74ca1e14b426351.json"}}], "type": "journal article", "published": "2023-04-18", "journal": {"title": "Clin Exp Immunol", "issn": "1365-2249", "issn-l": null}, "abstract": "Antigen-specific class-switched antibodies are detected at the same time or even before IgM in serum of non-vaccinated individuals infected with SARS-CoV-2. These derive from the first wave of plasmablasts formed. The phenotype and specificity of plasmablasts can reveal information about early B cell activation. Here we have analyzed B cells and plasmablasts circulating in blood of COVID-19 patients not previously exposed to SARS-CoV-2 during and after disease. We find that during infection with the original Wuhan strain, plasmablasts in blood produce IgA1, IgG1 and IgM, and that most express CCR10 and integrin \u03b21, only some integrin \u03b27, while the majority lack CCR9. Plasmablast-secreted antibodies are reactive to the Spike (S) and Nucleocapsid (N) proteins of the Wuhan strain as well as later variants of concern, but also bind S proteins from endemic and non-circulating betacoronaviruses. In contrast, after recovery, antibodies produced from memory B cells target variants of SARS-CoV-2 and SARS-CoV-1 but compared to previously non-infected individuals do not show increased binding to endemic coronaviruses. This suggests that the early antibody response to a large extent stems from pre-existing cross-reactive class-switched memory B cells, but that that although newly formed memory cells target the novel SARS-CoV-2 virus the numbers of broadly cross-reactive memory B cells do not increase extensively. The observations give insight into the role of pre-existing memory B cells in early antibody responses to novel pathogens and may explain why class-switched antibodies are detected early in serum of COVID-19 patients.", "doi": "10.1093/cei/uxad044", "pmid": "37071584", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "7127793"}], "notes": [], "created": "2023-04-20T17:21:24.291Z", "modified": "2023-04-20T17:21:48.207Z"}, {"entity": "publication", "iuid": "a7144432b32143a1949e61e162ef5874", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7144432b32143a1949e61e162ef5874.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7144432b32143a1949e61e162ef5874"}}, "title": "Contact allergy investigations in healthcare workers with face mask-related skin disease.", "authors": [{"family": "Brynolf", "given": "Andreas", "initials": "A", "orcid": "0009-0008-9710-8048", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e085284ebd94b34892969d3c8b364f0.json"}}, {"family": "Hauksson", "given": "Inese", "initials": "I"}, {"family": "Bergendorff", "given": "Ola", "initials": "O"}, {"family": "Svedman", "given": "Cecilia", "initials": "C", "orcid": "0000-0003-4797-0269", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fda1bd9c72f346e499ff64aef7394a56.json"}}, {"family": "Hamnerius", "given": "Nils", "initials": "N", "orcid": "0000-0001-5188-7711", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee788e8a5610497c9ef14e0860375614.json"}}], "type": "journal article", "published": "2023-04-18", "journal": {"title": "Contact Dermatitis", "issn": "1600-0536", "issn-l": null}, "abstract": "During the COVID-19 pandemic, the use of face masks has increased among healthcare workers (HCWs). Questionnaire studies have shown a high frequency of self-reported facial adverse skin reactions. Case reports have been published on face mask-induced allergic contact dermatitis and urticaria.\n\nTo describe the results of the contact allergy investigations in consecutive HCWs investigated for skin reactions to face masks during the COVID-19 pandemic and the results of the chemical investigations of face masks supplied by the hospital.\n\nParticipants were patch tested with baseline series and chemicals previously reported in face masks not included in the baseline series. Face mask(s) brought by the HCW were tested as is and/or in acetone extract. Chemical analyses were performed on nine different face masks for potential allergens.\n\nFifty-eight HCWs were investigated. No contact allergies were found to the face mask(s) tested. Eczema was the most common type of skin reaction, followed by an acneiform reaction. Colophonium-related substances were found in one respirator and 2,6-di-t-butyl-4-methylphenol (BHT) were found in two respirators.\n\nBased on this report, contact allergies to face masks is uncommon. Patch test with colophonium-related substances and BHT should be considered when investigating adverse skin reactions to face masks.", "doi": "10.1111/cod.14318", "pmid": "37072615", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-20T17:20:30.491Z", "modified": "2023-04-20T17:20:30.634Z"}, {"entity": "publication", "iuid": "17cd812532714081a54e15e64974b1a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/17cd812532714081a54e15e64974b1a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/17cd812532714081a54e15e64974b1a0"}}, "title": "Perceived effects of the COVID-19 pandemic on clinical psychology internships in Sweden.", "authors": [{"family": "Bergvall", "given": "Hillevi", "initials": "H", "orcid": "0000-0003-4091-0757", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41be49533571498f99e4542697b14c65.json"}}, {"family": "Larsson", "given": "Cornelia", "initials": "C", "orcid": "0000-0002-3860-0031", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6b2ff2a74f94af4936beb9bf511c9de.json"}}, {"family": "Str\u00e5lin", "given": "Elinor Eskilsson", "initials": "EE", "orcid": "0000-0002-1194-0968", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29195ee7e8b8468dad955f63f4308f5d.json"}}, {"family": "Bohman", "given": "Benjamin", "initials": "B", "orcid": "0000-0002-3415-7511", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/691b47f0c00d431eb46863b5f5c4b5d2.json"}}, {"family": "Alfonsson", "given": "Sven", "initials": "S", "orcid": "0000-0003-4570-5891", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c3e238a169547c596d13c7199defb7a.json"}}], "type": "journal article", "published": "2023-04-17", "journal": {"title": "BMC Med Educ", "issn": "1472-6920", "volume": "23", "issue": "1", "pages": "249", "issn-l": null}, "abstract": "The COVID-19 pandemic has had an unprecedented impact on societies and health care services worldwide, including the clinical training of psychology interns. Some of the pandemic-related restrictions were in breach of the internship requirements, increasing the risk of failed internships and a shortage of new health care professionals. This situation needed to be assessed.\n\nWeb-based surveys were administered to clinical psychology interns in Sweden 2020 (n = 267) and 2021 (n = 340), as well as to supervisors in 2020 (n = 240). The supervisors also provided information about their interns (n = 297).\n\nRisk factors for a prolonged internship, such as pandemic-related absence from work (12.4% in 2020 and 7.9% in 2021), unqualified work (0% in 2020, 3% in 2021), and change in internship content were low. However, remote interactions using digital services increased. Face-to-face patient contacts decreased significantly from 2020 to 2021 (\u03a72 = 5.17, p = .023), while remote work and remote supervision increased significantly (\u03a72 = 53.86, p < .001 and \u03a72 = 8.88, p = .003, respectively). Still, the content in patient contacts and supervision was maintained. Most interns reported no difficulties with remote supervision or supervision in personal protective equipment. However, of the interns who reported difficulties, role-play and skills training in remote supervision were perceived as significantly harder (\u03a72 = 28.67, p < .001) than in supervision using personal protective equipment.\n\nThe present study indicates that clinical training of psychology interns in Sweden could proceed despite a societal crisis. Results suggest that the psychology internship was flexible in the sense that it could be realized in combined face-to-face and remote formats without losing much of its value. However, the results also suggest that some skills may be harder to train in remote supervision.", "doi": "10.1186/s12909-023-04236-x", "pmid": "37069581", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12909-023-04236-x"}, {"db": "pmc", "key": "PMC10106869"}], "notes": [], "created": "2023-04-20T17:22:13.234Z", "modified": "2023-04-20T17:22:13.409Z"}, {"entity": "publication", "iuid": "469629c631504233b7d149d25ba0b295", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/469629c631504233b7d149d25ba0b295.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/469629c631504233b7d149d25ba0b295"}}, "title": "Impact of the COVID-19 pandemic on sick leave among healthcare workers: a register-based observational study.", "authors": [{"family": "Reme", "given": "Bj\u00f8rn-Atle", "initials": "BA"}, {"family": "Gr\u00f8sland", "given": "Mari", "initials": "M", "orcid": "0000-0001-6992-0620", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b6e933f49c14291aaee6aec14079e70.json"}}, {"family": "Gjefsen", "given": "Hege", "initials": "H"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2023-04-17", "journal": {"title": "Occup Environ Med", "issn": "1470-7926", "issn-l": null}, "abstract": "To assess the impact of the COVID-19 pandemic on sick leave among healthcare workers (HCWs) in primary and specialist care and examine its causes.\n\nUsing individual-level register data, we studied monthly proportions of sick leave (all-cause and not related to SARS-CoV-2 infection) from 2017 to February 2022 for all HCWs in primary (N=60 973) and specialist care (N=34 978) in Norway. First, we estimated the impact of the pandemic on sick leave, by comparing the sick leave rates during the pandemic to sick leave rates in 2017-2019. We then examined the impact of COVID-19-related workload on sick leave, by comparing HCWs working in healthcare facilities with different levels of COVID-19 patient loads.\n\nHCWs had elevated monthly rates of all-cause sick leave during the COVID-19 pandemic of 2.8 (95% CI 2.67 to 2.9) and 2.2 (95% CI 2.07 to 2.35) percentage points in primary and specialist care. The corresponding increases for sick leave not related to SARS-CoV-2 infection were 1.2 (95% CI 1.29 to 1.05) and 0.7 (95% CI 0.52 to 0.78) percentage points. All-cause sick leave was higher in areas with high versus low COVID-19 workloads. However, after removing sick leave episodes due to SARS-CoV-2 infections, there was no difference.\n\nThere was a substantial increase in sick leave among HCWs during the pandemic. Our results suggest that the increase was due to HCWs becoming infected with SARS-CoV-2 and/or sector-wide effects, such as strict infection control measures. More differentiated countermeasures should, therefore, be evaluated to limit capacity constraints in healthcare provision.", "doi": "10.1136/oemed-2022-108555", "pmid": "37068949", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "oemed-2022-108555"}], "notes": [], "created": "2023-04-20T17:22:31.021Z", "modified": "2023-04-20T17:22:39.702Z"}, {"entity": "publication", "iuid": "25bbb9029a374ed995bb6332097b568e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/25bbb9029a374ed995bb6332097b568e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/25bbb9029a374ed995bb6332097b568e"}}, "title": "Myeloperoxidase Inhibition in Heart Failure With Preserved or Mildly Reduced Ejection Fraction: SATELLITE Trial Results.", "authors": [{"family": "Lam", "given": "Carolyn S P", "initials": "CSP"}, {"family": "Lund", "given": "Lars H", "initials": "LH"}, {"family": "Shah", "given": "Sanjiv J", "initials": "SJ"}, {"family": "Voors", "given": "Adriaan A", "initials": "AA"}, {"family": "Erlinge", "given": "David", "initials": "D"}, {"family": "Saraste", "given": "Antti", "initials": "A"}, {"family": "Pirazzi", "given": "Carlo", "initials": "C"}, {"family": "Grove", "given": "Erik L", "initials": "EL"}, {"family": "Barasa", "given": "Anders", "initials": "A"}, {"family": "Schou", "given": "Morten", "initials": "M"}, {"family": "Aziz", "given": "Ahmed", "initials": "A"}, {"family": "Svedlund", "given": "Sara", "initials": "S"}, {"family": "Wijngaarden", "given": "Jan VAN", "initials": "JV"}, {"family": "Lindstedt", "given": "Eva-Lotte", "initials": "EL"}, {"family": "Gustavsson", "given": "Andreas", "initials": "A"}, {"family": "Nelander", "given": "Karin", "initials": "K"}, {"family": "Garkaviy", "given": "Pavlo", "initials": "P"}, {"family": "Gan", "given": "Li-Ming", "initials": "LM"}, {"family": "Gabrielsen", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2023-04-16", "journal": {"title": "J Card Fail", "issn": "1532-8414", "issn-l": null}, "abstract": "Inflammation is a key driver of heart failure (HF) with preserved left ventricular ejection fraction (LVEF). AZD4831 inhibits extracellular myeloperoxidase, reduces inflammation and improves microvascular function in preclinical disease models.\n\nIn this double-blind phase 2a study (SATELLITE; NCT03756285), patients with symptomatic HF, LVEF \u226540%, and elevated B-type natriuretic peptides were randomized 2:1 to once-daily oral AZD4831 5 mg or placebo for 90 days. We aimed to assess target engagement (primary endpoint: myeloperoxidase specific activity) and safety of AZD4831.\n\nDue to COVID-19, the study was terminated early after randomizing 41 patients (median age, 74.0 years; 53.7% male). Myeloperoxidase activity was reduced by >50% from baseline to day 30 and 90 in the AZD4831 group, with a placebo-adjusted reduction of 75% (95% confidence interval: 48, 88; nominal P <0.001). No improvements were noted in secondary/exploratory endpoints, apart from a trend in Kansas City Cardiomyopathy Questionnaire overall summary score. No deaths or treatment-related serious adverse events occurred. AZD4831 treatment-related adverse events were generalized maculopapular rash, pruritus and diarrhoea (all n=1).\n\nAZD4831 inhibited myeloperoxidase and was well tolerated in patients with HF and LVEF \u226540%. Efficacy findings were exploratory due to early termination but warrant further clinical investigation of AZD4831.\n\nFew treatments are available for patients with the forms of heart failure known as 'heart failure with preserved or mildly reduced ejection fraction'. Current treatments do not target inflammation, which may play an important role in this condition. We tested a new drug called AZD4831 (mitiperstat), which reduces inflammation by inhibiting the enzyme myeloperoxidase. Among the 41 patients in our clinical trial, AZD4831 had a good safety profile and inhibited myeloperoxidase by the expected amount. Results mean we can conduct further trials to see whether AZD4831 reduces the symptoms of heart failure and improves patients' ability to take physical exercise.", "doi": "10.1016/j.cardfail.2023.04.003", "pmid": "37072105", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1071-9164(23)00142-2"}], "notes": [], "created": "2023-04-20T17:20:48.792Z", "modified": "2023-04-20T17:20:48.822Z"}, {"entity": "publication", "iuid": "60c043206a064d22b94115553cd77baa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60c043206a064d22b94115553cd77baa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60c043206a064d22b94115553cd77baa"}}, "title": "Nurses and global health responsibility: In light of the COVID-19 pandemic and the war in Ukraine.", "authors": [{"family": "Lindberg", "given": "Catharina", "initials": "C", "orcid": "0000-0001-7552-2717", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c36291c5c6394f01beddc951f2272b88.json"}}, {"family": "Brinchmann", "given": "Berit St\u00f8re", "initials": "BS", "orcid": "0000-0001-6541-4931", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6ed725c0172415f836219836632d987.json"}}], "type": "journal article", "published": "2023-04-15", "journal": {"title": "Int Nurs Rev", "issn": "1466-7657", "issn-l": null}, "abstract": "The aim of this paper was to reflect on global ethical challenges for nurses in light of the COVID-19 pandemic and the war in Ukraine and to discuss 'Nurses and Global Health', a new element in the revised ICN Code of Ethics for Nurses, 2021, and its implications for nurses.\n\nThe authors participated in the latest revision of the Code. When we were revising the ICN Code of Ethics, there was neither an ongoing pandemic nor a war in Europe.\n\nRelevant scientific articles and other academic literature, documents from international organisations, and authors' views.\n\nThe discussion emanated from our reflections on how to actually apply the ICN Code of Ethics, i.e., moving the words from the document itself into everyday practice, in light of the COVID-19 pandemic and the war in Ukraine. In the Code, the nurse's responsibility is highlighted, but there is little or no instruction on how to undertake it.\n\nThe ICN Code of Ethics needs to be operationalised through ethical reflection and discussion in all contexts where nurses work, from policy level to the care environment.", "doi": "10.1111/inr.12844", "pmid": "37060544", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-20T17:23:49.316Z", "modified": "2023-04-20T17:23:49.402Z"}, {"entity": "publication", "iuid": "89c2bbb82ff644319505cb83111e7a28", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/89c2bbb82ff644319505cb83111e7a28.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/89c2bbb82ff644319505cb83111e7a28"}}, "title": "Delayed generation of functional virus-specific circulating T follicular helper cells correlates with severe COVID-19.", "authors": [{"family": "Yu", "given": "Meng", "initials": "M", "orcid": "0000-0002-9798-6624", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b6ab0fe226324dddbb38d008f92767de.json"}}, {"family": "Charles", "given": "Afandi", "initials": "A", "orcid": "0000-0003-0022-3303", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f96e5b81f0ee44938ebf4123dffeba1e.json"}}, {"family": "Cagigi", "given": "Alberto", "initials": "A"}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f2dc27d02294a15a6f691be6aab641f.json"}}, {"family": "\u00d6sterberg", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Falck-Jones", "given": "Sara", "initials": "S"}, {"family": "Azizmohammadi", "given": "Lida", "initials": "L"}, {"family": "\u00c5hlberg", "given": "Eric", "initials": "E"}, {"family": "Falck-Jones", "given": "Ryan", "initials": "R", "orcid": "0000-0002-0985-8658", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b100f8839744b7681180a84162a1625.json"}}, {"family": "Svensson", "given": "Julia", "initials": "J"}, {"family": "Nie", "given": "Mu", "initials": "M"}, {"family": "Warnqvist", "given": "Anna", "initials": "A"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Lenart", "given": "Klara", "initials": "K", "orcid": "0000-0002-4984-2618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/695f9cad72624d87a09626b8097d654d.json"}}, {"family": "Arcoverde Cerveira", "given": "Rodrigo", "initials": "R", "orcid": "0000-0002-1145-2534", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/967497a8624d4a889ba820aa8fe42336.json"}}, {"family": "Ols", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-9784-7176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35eb7b8de6434661a729bab979f26c7d.json"}}, {"family": "Lindgren", "given": "Gustaf", "initials": "G"}, {"family": "Lin", "given": "Ang", "initials": "A"}, {"family": "Maecker", "given": "Holden", "initials": "H", "orcid": "0000-0003-0795-9946", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f643c4e99634951a332a6757953878f.json"}}, {"family": "Bell", "given": "Max", "initials": "M", "orcid": "0000-0001-7464-0324", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/530f7609a1f143b69691db5c41b14412.json"}}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Albert", "given": "Jan", "initials": "J", "orcid": "0000-0001-9020-0521", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79a6c7eedadb4a1e8c6fd7b8b522a8e3.json"}}, {"family": "Sundling", "given": "Christopher", "initials": "C", "orcid": "0000-0002-6138-690X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/95f99b6d6c464221919a437b88b46b54.json"}}, {"family": "Czarnewski", "given": "Paulo", "initials": "P"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "F\u00e4rnert", "given": "Anna", "initials": "A"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K", "orcid": "0000-0001-7679-9494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02d4d3d9ccc547f7ab18ba69493f6a34.json"}}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A", "orcid": "0000-0001-6966-7039", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0c96bf27aca45f6b460a555c5425e2d.json"}}], "type": "journal article", "published": "2023-04-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "2164", "issn-l": "2041-1723"}, "abstract": "Effective humoral immune responses require well-orchestrated B and T follicular helper (Tfh) cell interactions. Whether these interactions are impaired and associated with COVID-19 disease severity is unclear. Here, longitudinal blood samples across COVID-19 disease severity are analysed. We find that during acute infection SARS-CoV-2-specific circulating Tfh (cTfh) cells expand with disease severity. SARS-CoV-2-specific cTfh cell frequencies correlate with plasmablast frequencies and SARS-CoV-2 antibody titers, avidity and neutralization. Furthermore, cTfh cells but not other memory CD4 T cells, from severe patients better induce plasmablast differentiation and antibody production compared to cTfh cells from mild patients. However, virus-specific cTfh cell development is delayed in patients that display or later develop severe disease compared to those with mild disease, which correlates with delayed induction of high-avidity neutralizing antibodies. Our study suggests that impaired generation of functional virus-specific cTfh cells delays high-quality antibody production at an early stage, potentially enabling progression to severe disease.", "doi": "10.1038/s41467-023-37835-9", "pmid": "37061513", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10105364"}, {"db": "pii", "key": "10.1038/s41467-023-37835-9"}], "notes": [], "created": "2023-04-17T14:41:16.708Z", "modified": "2023-04-20T17:23:35.166Z"}, {"entity": "publication", "iuid": "a2c1bd96eca245a49b5934f9d2949300", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2c1bd96eca245a49b5934f9d2949300.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2c1bd96eca245a49b5934f9d2949300"}}, "title": "SARS-CoV-2 Antibodies in Commercial Immunoglobulin Products Show Markedly Reduced Cross-reactivities Against Omicron Variants.", "authors": [{"family": "Lindahl", "given": "Hannes", "initials": "H", "orcid": "0000-0002-4447-9426", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae08b00dd81545eab451b58ce0c0481b.json"}}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE"}, {"family": "Bergman", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2023-04-14", "journal": {"title": "J Clin Immunol", "issn": "1573-2592", "pages": "1-8", "issn-l": "0271-9142"}, "abstract": "Patients with antibody deficiencies often receive maintenance treatment with donor plasma-derived immunoglobulin (Ig) preparations to decrease the incidence and severity of infections. We have previously shown that IgG antibodies to the original SARS-CoV-2 strain were not consistently present in off-the-shelf Ig batches produced up to approximately 18 months after the first identified case of COVID-19 in the USA and that Ig batches with anti-SARS-CoV-2 IgG primarily contained vaccine-induced spike specific antibodies. This study aimed to investigate the degree of cross-reactivity between vaccine-induced anti-SARS-CoV-2 antibodies against Wuhan strain and subsequent viral variants.\n\nSamples were collected from 74 Ig batches supplied by three different commercial manufacturers. All batches were used at the Immunodeficiency Unit at the Karolinska University Hospital from the start of the SARS-CoV-2 pandemic until September 2022. Antibody quantity and potential to neutralize virus entry into host cells were assessed against the original SARS-CoV-2 Wuhan strain and the following nine variants: Alpha, Beta, Delta, IHU, and the Omicron BA.1, BA.1.1, BA.1 with spike mutation L452R, BA.2, and BA.3.\n\nIg batches produced approximately 18 months after the SARS-CoV-2 outbreak (from around July 2021) and later consistently contained high quantities of antibodies that bind the Wuhan strain. The Ig batches had overall low reactivity to the SARS-CoV-2 nucleocapsid, which implies that plasma donor spike IgG essentially is the result of vaccination. We assessed the degree of cross-reactivity towards each virus variant by plotting the variant/Wuhan strain ratio, which was consistent regardless of production date, suggesting cross-reactivity with vaccine-induced antibodies rather than virus exposure in the plasma donor population. Viral variants that emerged later during the pandemic systematically had a lower reactivity ratio, except for the Delta and IHU variants. The Ig batches displayed markedly low neutralizing potential towards the Beta variant and all tested Omicron variants.\n\nCommercial Ig batches currently contain large quantities of SARS-CoV-2 vaccine-induced antibodies. Cross-reactivity with variant strains is evident but varies, with markedly low neutralizing potential observed against Omicron variants.", "doi": "10.1007/s10875-023-01486-8", "pmid": "37058198", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10102687"}, {"db": "pii", "key": "10.1007/s10875-023-01486-8"}], "notes": [], "created": "2023-04-20T17:24:45.566Z", "modified": "2023-04-20T17:25:41.233Z"}, {"entity": "publication", "iuid": "fcd7bbf7cd1043369c2e770f00871b66", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fcd7bbf7cd1043369c2e770f00871b66.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fcd7bbf7cd1043369c2e770f00871b66"}}, "title": "Impact of SARS-CoV-2 vaccination and monoclonal antibodies on outcome post CD19-CAR-T: an EPICOVIDEHA survey.", "authors": [{"family": "van Doesum", "given": "Jaap A", "initials": "JA", "orcid": "0000-0003-0214-3219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49152311cb004139904554d1c096c05c.json"}}, {"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J", "orcid": "0000-0002-6766-8297", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dea501020d2042ad83d1b024987792f4.json"}}, {"family": "Marchesi", "given": "Francesco", "initials": "F"}, {"family": "Di Blasi", "given": "Roberta", "initials": "R", "orcid": "0000-0001-9001-573X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b0e256f42ad4d25aef901a2c2df7eab.json"}}, {"family": "Falces-Romero", "given": "Iker", "initials": "I"}, {"family": "Cabirta", "given": "Alba", "initials": "A", "orcid": "0000-0001-7198-8894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ca8361c64eb4563a0f090faaf569e8a.json"}}, {"family": "Farina", "given": "Francesca", "initials": "F"}, {"family": "Besson", "given": "Caroline", "initials": "C", "orcid": "0000-0003-4364-7173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adc322a60efe4963a3ff76aa00c885d6.json"}}, {"family": "Weinbergerov\u00e1", "given": "Barbora", "initials": "B", "orcid": "0000-0001-6460-2471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7ef50b8f8dc457ab2badd8481b3fa86.json"}}, {"family": "Van Praet", "given": "Jens", "initials": "J", "orcid": "0000-0002-7125-7001", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ebcaace10774e8c8727b0638e5ec075.json"}}, {"family": "Sch\u00f6nlein", "given": "Martin", "initials": "M", "orcid": "0000-0002-1010-0975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bc914f4fd004b8695f47c8ef5373941.json"}}, {"family": "Lopez-Garcia", "given": "Alberto", "initials": "A"}, {"family": "Lamure", "given": "Sylvain", "initials": "S"}, {"family": "Guidetti", "given": "Anna", "initials": "A"}, {"family": "De Ram\u00f3n-S\u00e1nchez", "given": "Cristina", "initials": "C", "orcid": "0000-0002-8167-6410", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d42267ab742491d95080c6592197d6a.json"}}, {"family": "Batinic", "given": "Josip", "initials": "J"}, {"family": "Gavriilaki", "given": "Eleni", "initials": "E", "orcid": "0000-0002-8883-8208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5c146006910e4affb970a1ffe9db5989.json"}}, {"family": "Tragiannidis", "given": "Athanasios", "initials": "A"}, {"family": "Tisi", "given": "Maria Chiara", "initials": "MC"}, {"family": "Plantefeve", "given": "Ga\u00ebtan", "initials": "G"}, {"family": "Petzer", "given": "Verena", "initials": "V", "orcid": "0000-0002-9205-1440", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b52c652fbe2245d1a3df0ca220d8ad98.json"}}, {"family": "Ormazabal-Velez", "given": "Irati", "initials": "I"}, {"family": "Marques de Almeida", "given": "Joyce", "initials": "J", "orcid": "0000-0002-0270-3805", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2459904a9cfe4ea78217373c8af0bea1.json"}}, {"family": "Marchetti", "given": "Monia", "initials": "M"}, {"family": "Maertens", "given": "Johan A", "initials": "JA", "orcid": "0000-0003-4257-5980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4701b45871ba4030a2c57c01edcbf6e0.json"}}, {"family": "Machado", "given": "Marina", "initials": "M", "orcid": "0000-0002-8370-2248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/333e7bffca6c41be995da05411c11248.json"}}, {"family": "Kulasekararaj", "given": "Austin G", "initials": "AG", "orcid": "0000-0003-3180-3570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd4719161efc4d939fe6f4832430a1bc.json"}}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jos\u00e9 \u00c1ngel", "initials": "J\u00c1"}, {"family": "Gomes da Silva", "given": "Maria", "initials": "M", "orcid": "0000-0002-6993-2450", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75ea48d40e3647f189db6f726b4819bc.json"}}, {"family": "Fern\u00e1ndez", "given": "Noem\u00ed", "initials": "N"}, {"family": "Espigado", "given": "Ildefonso", "initials": "I", "orcid": "0000-0002-4043-6613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40c943f7cd0e40998a4a1ae519a39e48.json"}}, {"family": "Drgona", "given": "Lubos", "initials": "L", "orcid": "0000-0002-5089-3201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/746b17dbdf2a4b178e6a11454778c725.json"}}, {"family": "Dragonetti", "given": "Giulia", "initials": "G"}, {"family": "Metafuni", "given": "Elisabetta", "initials": "E", "orcid": "0000-0002-4780-1273", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96f59852bc434fb6968356ec092e911b.json"}}, {"family": "Calbacho", "given": "Maria", "initials": "M"}, {"family": "Blennow", "given": "Ola", "initials": "O", "orcid": "0000-0002-7167-7882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2318c3973e66443aa14fceca0908d127.json"}}, {"family": "Wolf", "given": "Dominik", "initials": "D"}, {"family": "van Anrooij", "given": "Bjorn", "initials": "B"}, {"family": "Nunes Rodrigues", "given": "Raquel", "initials": "R"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Mart\u00edn-Gonz\u00e1lez", "given": "Juan-Alberto", "initials": "JA", "orcid": "0000-0002-3734-921X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a309fa9dc9d4f1c93bd9821205a2f72.json"}}, {"family": "Lievin", "given": "Rapha\u00ebl", "initials": "R", "orcid": "0000-0002-5097-591X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d190434cf5f428f9714a761a1b67889.json"}}, {"family": "Jim\u00e9nez", "given": "Moraima", "initials": "M", "orcid": "0000-0003-1444-8562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c9e09b030ce4f8480230679f8c643be.json"}}, {"family": "Grafe", "given": "Stefanie K", "initials": "SK", "orcid": "0000-0001-7678-0179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6f9279444f64b529761a37a0d2448f4.json"}}, {"family": "Garcia-Sanz", "given": "Ramon", "initials": "R"}, {"family": "C\u00f3rdoba", "given": "Ra\u00fal", "initials": "R"}, {"family": "Rahimli", "given": "Laman", "initials": "L"}, {"family": "van Meerten", "given": "Tom", "initials": "T"}, {"family": "Cornely", "given": "Oliver A", "initials": "OA", "orcid": "0000-0001-9599-3137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3c62d8346924e69b6c99e4007c3831c.json"}}, {"family": "Pagano", "given": "Livio", "initials": "L", "orcid": "0000-0001-8287-928X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbf92a9779614910aeafcc6c21d880e2.json"}}], "type": "journal article", "published": "2023-04-14", "journal": {"title": "Blood Adv", "issn": "2473-9537", "issn-l": null}, "abstract": "Patients with previous CD19 directed chimeric antigen receptor T cell therapy (CAR T)-cell therapy have a prolonged vulnerability to viral infections. Coronavirus diseases 2019 (COVID-19) has a great impact and has previously been shown to cause high mortality in this population. Until now, real world data of the impact of vaccination and treatment on patients with COVID-19 after CD19 directed CAR T-cell therapy are lacking. Therefore, this multicenter retrospective study was conducted with data from the EPICOVIDEHA survey. Sixty-four patients were identified. The overall mortality caused by COVID-19 was 31%. Patients infected with the Omicron variant had a significantly lower risk of death due to COVID-19 compared to patients infected with previous variants (7% versus 58% (P=0.012)). Twenty-six patients were vaccinated at time of COVID-19 diagnosis. Two vaccinations showed marked but unsignificant reduction risk of COVID-19 caused mortality (33.3% versus 14.2% (P=0.379)).Also the course of disease appears milder with less frequent ICU admissions (39% versus 14% (P=0.054)) and shorter duration of hospitalization (7 versus 27.5 days (P=0.022)). Of the available treatment options, only monoclonal antibodies seemed to be effectively reducing mortality from 32% to zero (P=0.036). We conclude that survival rates of CAR T-cell recipients with COVID-19 improved over time and that the combination of prior vaccination and monoclonal antibody treatment significantly reduces their risk of death.", "doi": "10.1182/bloodadvances.2022009578", "pmid": "37058479", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "495340"}], "notes": [], "created": "2023-04-20T17:24:06.886Z", "modified": "2023-04-20T17:25:18.658Z"}, {"entity": "publication", "iuid": "e61559363def444894ce2eac0fa0c060", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e61559363def444894ce2eac0fa0c060.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e61559363def444894ce2eac0fa0c060"}}, "title": "Better Anti-Spike IgG Antibody Response to SARS-CoV-2 Vaccine in Patients on Haemodiafiltration than on Haemodialysis.", "authors": [{"family": "Carrera", "given": "Fernando", "initials": "F"}, {"family": "Jacobson", "given": "Stefan H", "initials": "SH"}, {"family": "Costa", "given": "Joana", "initials": "J"}, {"family": "Marques", "given": "Marco", "initials": "M"}, {"family": "Ferrer", "given": "Francisco", "initials": "F"}], "type": "journal article", "published": "2023-04-14", "journal": {"title": "Blood Purif", "issn": "1421-9735", "pages": "1-8", "issn-l": null}, "abstract": "The antibody response to SARS-CoV-2 vaccine in haemodialysis (HD) patients is diminished compared to healthy subjects. The aim of this study was to compare the presence of reactive SARS-CoV-2 antibodies in patients with high-flux HD and on-line haemodiafiltration (HDF) three and 6 months after the second dose of SARS-CoV-2 vaccine since previous studies indicate that a sustained antibody response correlates with protection from disease.\n\nWe included 216 HD patients of which 157 had on-line HDF and 59 high-flux HD and 46 health care workers as controls and studied the presence of reactive anti-spike IgG antibodies three and 6 months after the second dose of SARS-CoV-2 vaccine. Clinical features between the patient groups were similar, but patients with on-line HDF had significantly higher Kt/V.\n\nThe percentage of participants with reactive antibodies was significantly lower in patients compared to controls, both three and 6 months after the second dose of vaccine. Furthermore, the proportion of patients with reactive anti-spike IgG \u22651.0 6 months after the second dose of vaccine was significantly higher in patients with on-line HDF compared to in patients with high-flux HD. In logistic regression analyses adjusted for several clinical features, the variables associated with presence of reactive anti-spike IgG at 3 months after the second dose of vaccine were lower age, HDF treatment, not being obese and not having a previous solid organ transplant. The two variables with the strongest influence on the presence of reactive anti-spike IgG levels 6 months after the second dose of vaccine were treatment with on-line HDF and not having immunosuppressive therapy.\n\nThis is the first study to show that on-line HDF preserves the antibody response better than high-flux HD after vaccination with SARS-CoV-2 vaccine. Treatment strategies that sustain the vaccine response are essential to apply in this vulnerable group of patients.", "doi": "10.1159/000529719", "pmid": "37062269", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "000529719"}], "notes": [], "created": "2023-04-20T17:23:13.282Z", "modified": "2023-04-20T17:23:13.295Z"}, {"entity": "publication", "iuid": "98d740c575f5461fb34c0f42799c3a1c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/98d740c575f5461fb34c0f42799c3a1c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/98d740c575f5461fb34c0f42799c3a1c"}}, "title": "Prevalence of long COVID complaints in persons with and without COVID-19.", "authors": [{"family": "Magnusson", "given": "Karin", "initials": "K"}, {"family": "Turkiewicz", "given": "Aleksandra", "initials": "A"}, {"family": "Flottorp", "given": "Signe Agnes", "initials": "SA"}, {"family": "Englund", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2023-04-13", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "13", "issue": "1", "pages": "6074", "issn-l": "2045-2322"}, "abstract": "We studied the prevalence and patterns of typical long COVID complaints in ~ 2.3 million individuals aged 18-70 years with and without confirmed COVID-19 in a Nation-wide population-based prospective cohort study in Norway. Our main outcome measures were the period prevalence of single-occurring or different combinations of complaints based on medical records: (1) Pulmonary (dyspnea and/or cough), (2) Neurological (concentration problems, memory loss), and/or (3) General complaints (fatigue). In persons testing positive (n = 75 979), 64 (95% confidence interval: 54 to 73) and 122 (111 to 113) more persons per 10 000 persons had pulmonary complaints 5-6 months after the test compared to 10 000 persons testing negative (n = 1 167 582) or untested (n = 1 084 578), respectively. The corresponding difference in prevalence of general complaints (fatigue) was 181 (168 to 195) and 224 (211 to 238) per 10 000, and of neurological complaints 5 (2 to 8) and 9 (6-13) per 10 000. Overlap between complaints was rare. Long COVID complaints were only slightly more prevalent in persons with than without confirmed COVID-19. Still, long COVID may pose a substantial burden to healthcare systems in the future given the lasting high incidence of symptomatic COVID-19 in both vaccinated and unvaccinated individuals.", "doi": "10.1038/s41598-023-32636-y", "pmid": "37055494", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC10100609"}, {"db": "pii", "key": "10.1038/s41598-023-32636-y"}], "notes": [], "created": "2023-04-20T17:26:10.891Z", "modified": "2023-04-20T17:26:10.896Z"}, {"entity": "publication", "iuid": "8d443acded49416b84400eec2820cb88", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d443acded49416b84400eec2820cb88.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d443acded49416b84400eec2820cb88"}}, "title": "Impact assessment of immunization and the COVID-19 pandemic on varicella across Europe using digital epidemiology methods: A descriptive study.", "authors": [{"family": "Sabale", "given": "Ugne", "initials": "U", "orcid": "0000-0003-1874-8730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8386a4d80734ee5bb684d2405977d75.json"}}, {"family": "Jarmale", "given": "Ligita", "initials": "L"}, {"family": "Murtagh", "given": "Janice", "initials": "J"}, {"family": "Pawaskar", "given": "Manjiri", "initials": "M"}, {"family": "Bencina", "given": "Goran", "initials": "G", "orcid": "0000-0001-6293-8211", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b5e3d769bcd43b9a8a76b70188ad470.json"}}], "type": "journal article", "published": "2023-04-12", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "18", "issue": "4", "pages": "e0283465", "issn-l": "1932-6203"}, "abstract": "Varicella is usually a mild disease in children but may be life-threatening, especially in adolescents and adults. Infection control measures implemented during the Coronavirus Disease 2019 (COVID-19) pandemic may have suppressed varicella transmission, potentially creating an 'immunity debt', particularly in countries without universal varicella vaccination.\n\nTo assess trends in Google search engine queries for varicella keywords as a proxy for varicella infection rates and to evaluate the effect of universal varicella vaccination on these trends. A further objective was to assess the impact of the COVID-19 pandemic on varicella keyword search query trends in countries with and without universal varicella vaccination.\n\nThis study used the keyword research tool, Google Trends, to evaluate trends in time series of the relative search query popularity of language-specific varicella keywords in 28 European countries from January 2015 through December 2021. The Google Ads Keyword Planner tool was used to evaluate absolute search volumes from March 2018 through December 2021.\n\nThe relative search query popularity of varicella keywords displayed marked seasonal variation. In all 28 countries, the relative search query popularity of varicella keywords declined after the start of the COVID-19 pandemic (March 2020), compared with pre-pandemic levels (range, -18% to -70%). From April 2020 to July 2021, a period of intense COVID-19 transmission and infection control, absolute search volumes for varicella keywords were lower than pre-pandemic levels but rebounded after July 2021, when infection control measures were relaxed.\n\nThis evaluation of search query trends demonstrated that search query data could be used as a proxy for trends in varicella infection rates and revealed that transmission of varicella may have been suppressed during the COVID-19 pandemic. Consideration should be given to using search query data to better understand the burden of varicella, particularly in countries where surveillance systems are inadequate.", "doi": "10.1371/journal.pone.0283465", "pmid": "37043422", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10096188"}, {"db": "pii", "key": "PONE-D-22-28976"}], "notes": [], "created": "2023-04-20T17:26:54.270Z", "modified": "2023-04-20T17:27:04.009Z"}, {"entity": "publication", "iuid": "781d1e6d1305446697e712e4bce7cb83", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/781d1e6d1305446697e712e4bce7cb83.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/781d1e6d1305446697e712e4bce7cb83"}}, "title": "Subclass-switched anti-spike IgG3 oligoclonal cocktails strongly enhance Fc-mediated opsonization.", "authors": [{"family": "Izadi", "given": "Arman", "initials": "A", "orcid": "0000-0002-0262-1017", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d36b0ac6385471b917f3be9131d4d57.json"}}, {"family": "Hailu", "given": "Arsema", "initials": "A"}, {"family": "Godzwon", "given": "Magdalena", "initials": "M", "orcid": "0000-0002-9745-1160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/386a6fc861e64386bf32de44d013277f.json"}}, {"family": "Wrighton", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-3378-7925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/740aa0208cea4c27a4297849cec4f9f9.json"}}, {"family": "Olofsson", "given": "Berit", "initials": "B", "orcid": "0009-0009-0602-2183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8cdf27b432648f3957550c8b99bc5b2.json"}}, {"family": "Schmidt", "given": "Tobias", "initials": "T"}, {"family": "S\u00f6derlund-Strand", "given": "Anna", "initials": "A", "orcid": "0009-0001-8886-4385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32d681c0fc724de18f0839cbc41f4f34.json"}}, {"family": "Elder", "given": "Elizabeth", "initials": "E", "orcid": "0000-0003-1615-2642", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f34193310b964fe4b87f65ca04193939.json"}}, {"family": "Appelberg", "given": "Sofia", "initials": "S", "orcid": "0000-0002-7381-3606", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a3e2ab8513742af91714b79b472734a.json"}}, {"family": "Valsj\u00f6", "given": "Maria", "initials": "M"}, {"family": "Larsson", "given": "Olivia", "initials": "O"}, {"family": "Wendel-Hansen", "given": "Vidar", "initials": "V", "orcid": "0009-0002-3179-1565", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e54287872af3447d9d35d0dca01f65b6.json"}}, {"family": "Ohlin", "given": "Mats", "initials": "M", "orcid": "0000-0002-5105-1938", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/def6c0678dfd48ea9a1255a8a00e7ebc.json"}}, {"family": "Bahnan", "given": "Wael", "initials": "W"}, {"family": "Nordenfelt", "given": "Pontus", "initials": "P", "orcid": "0000-0002-9481-9951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe1c1345d0bf4316bead223ad6c9f8a8.json"}}], "type": "journal article", "published": "2023-04-11", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "120", "issue": "15", "pages": "e2217590120", "issn-l": "0027-8424"}, "abstract": "Antibodies play a central role in the immune defense against SARS-CoV-2. Emerging evidence has shown that nonneutralizing antibodies are important for immune defense through Fc-mediated effector functions. Antibody subclass is known to affect downstream Fc function. However, whether the antibody subclass plays a role in anti-SARS-CoV-2 immunity remains unclear. Here, we subclass-switched eight human IgG1 anti-spike monoclonal antibodies (mAbs) to the IgG3 subclass by exchanging their constant domains. The IgG3 mAbs exhibited altered avidities to the spike protein and more potent Fc-mediated phagocytosis and complement activation than their IgG1 counterparts. Moreover, combining mAbs into oligoclonal cocktails led to enhanced Fc- and complement receptor-mediated phagocytosis, superior to even the most potent single IgG3 mAb when compared at equivalent concentrations. Finally, in an in vivo model, we show that opsonic mAbs of both subclasses can be protective against a SARS-CoV-2 infection, despite the antibodies being nonneutralizing. Our results suggest that opsonic IgG3 oligoclonal cocktails are a promising idea to explore for therapy against SARS-CoV-2, its emerging variants, and potentially other viruses.", "doi": "10.1073/pnas.2217590120", "pmid": "37011197", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-04-12T16:48:19.412Z", "modified": "2023-04-12T16:48:36.407Z"}, {"entity": "publication", "iuid": "7481bb67ff36401c896db17824f69322", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7481bb67ff36401c896db17824f69322.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7481bb67ff36401c896db17824f69322"}}, "title": "The impact of Covid-19 in patients with chronic myeloid leukemia-a nationwide population-based study.", "authors": [{"family": "Dahl\u00e9n", "given": "Torsten", "initials": "T", "orcid": "0000-0002-3856-7227", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69a3a4703c134438836a76bd0dec1c68.json"}}, {"family": "Flygt", "given": "Hjalmar", "initials": "H"}, {"family": "L\u00fcbking", "given": "Anna", "initials": "A"}, {"family": "Olsson-Str\u00f6mberg", "given": "Ulla", "initials": "U"}, {"family": "Wennstr\u00f6m", "given": "Lovisa", "initials": "L"}, {"family": "Dreimane", "given": "Arta", "initials": "A"}, {"family": "Sj\u00e4lander", "given": "Anders", "initials": "A", "orcid": "0000-0001-9422-1186", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/290cd473f57946678cf6a391cf58c120.json"}}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Li", "given": "Huiqi", "initials": "H", "orcid": "0000-0002-1127-0829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e3bd3ff6b4e4f448f9332081da1dc29.json"}}, {"family": "H\u00f6glund", "given": "Martin", "initials": "M"}, {"family": "Stenke", "given": "Leif", "initials": "L"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2023-04-10", "journal": {"title": "Leukemia", "issn": "1476-5551", "pages": "1-4", "issn-l": null}, "abstract": null, "doi": "10.1038/s41375-023-01893-1", "pmid": "37037908", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10088575"}, {"db": "pii", "key": "10.1038/s41375-023-01893-1"}], "notes": [], "created": "2023-04-17T14:42:01.368Z", "modified": "2023-04-20T17:29:07.885Z"}, {"entity": "publication", "iuid": "90572370bf5049dba72acc96b9bff5bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90572370bf5049dba72acc96b9bff5bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90572370bf5049dba72acc96b9bff5bd"}}, "title": "The febrile infant: Is it COVID-19 or a serious bacterial infection?", "authors": [{"family": "Ohlin", "given": "Andreas", "initials": "A", "orcid": "0000-0003-0531-6189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ba9ad0ed35f4cbc94aff40e614dbb03.json"}}], "type": "editorial", "published": "2023-04-10", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253"}, "abstract": null, "doi": "10.1111/apa.16783", "pmid": "37035897", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2023-04-20T17:29:19.414Z", "modified": "2023-04-20T17:29:19.451Z"}, {"entity": "publication", "iuid": "e33999b56fec47e29b9dbf27d95de814", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e33999b56fec47e29b9dbf27d95de814.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e33999b56fec47e29b9dbf27d95de814"}}, "title": "Family doctors' roles and perceptions on antibiotic consumption and antibiotic resistance in Romania: a qualitative study.", "authors": [{"family": "Ghiga", "given": "Ioana", "initials": "I"}, {"family": "Pitchforth", "given": "Emma", "initials": "E"}, {"family": "St\u00e5lsby Lundborg", "given": "Cecilia", "initials": "C"}, {"family": "Machowska", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2023-04-10", "journal": {"title": "BMC Prim Care", "issn": "2731-4553", "volume": "24", "issue": "1", "pages": "93", "issn-l": null}, "abstract": "Antimicrobial resistance (AMR) is a major global health issue, bringing significant health burden and costs to societies. Increased antibiotic consumption (ABC) is linked to AMR emergence. Some of the known drivers of ABC are antibiotics over-prescription by physicians and their misuse by patients. Family doctors are recognised as important stakeholders in the control of ABC as they prescribe antibiotics and are considered a reliable source of medical information by patients. Therefore, it is important to explore their perceptions, especially in Romania, which has the highest ABC among European Union Member States. Furthermore, there is no published research exploring Romanian family doctors' perceptions regarding this phenomenon.\n\nThis was a qualitative study with data collection via semi-structured interviews among 12 family doctors. Manifest and latent content analysis was used to gain an in-depth understanding of their perceptions. Findings were mapped onto the domains of the Behaviour Change Wheel to facilitate a theory driven systematization and analysis.\n\nTwo main subthemes emerged: i) factors affecting ABC and prescribing and ii) potential interventions to tackle ABC and antibiotic resistance. The factors were further grouped in those that related to the perceived behaviour of family doctors or patients as well as those that had to do with the various systems, local contexts and the COVID-19 pandemic. An overarching theme: 'family doctors in Romania see their role differently when it comes to antibiotic resistance and perceive the lack of patient education or awareness as one of the major drivers of ABC' was articulated. The main findings suggested that the perceived factors span across the capability, opportunity and motivational domains of the behaviour change wheel and could be addressed through a variety of interventions - some identified by the participants. Findings can also be viewed through cultural lenses which shed further light on the family doctor- patient dynamic when it comes to antibiotics use.\n\nPotential interventions to tackle identified factors emerged, revolving mostly on efforts to educate patients or the public. This exploratory research provides key perspectives and facilitates further research on potential interventions to successfully address AMR in Romania or similar settings.", "doi": "10.1186/s12875-023-02047-z", "pmid": "37038124", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10084585"}, {"db": "pii", "key": "10.1186/s12875-023-02047-z"}], "notes": [], "created": "2023-04-20T17:28:19.348Z", "modified": "2023-04-20T17:28:19.361Z"}, {"entity": "publication", "iuid": "ae8737f2cf2e43f4bde138652616bc8d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ae8737f2cf2e43f4bde138652616bc8d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ae8737f2cf2e43f4bde138652616bc8d"}}, "title": "How Older Persons and Health Care Professionals Co-designed a Medication Plan Prototype Remotely to Promote Patient Safety: Case Study.", "authors": [{"family": "Holmqvist", "given": "Malin", "initials": "M", "orcid": "0000-0003-3221-9800", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1ccb090de9941ef9c9198efe68ae74a.json"}}, {"family": "Ros", "given": "Axel", "initials": "A", "orcid": "0000-0001-6302-8068", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a05b39ead83344668c7baeb3e9b9dae6.json"}}, {"family": "Lindenfalk", "given": "Bertil", "initials": "B", "orcid": "0000-0003-0123-6392", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f070b0a31bfa4d14a84541618e813961.json"}}, {"family": "Thor", "given": "Johan", "initials": "J", "orcid": "0000-0003-1814-4478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a3b8c916bd0496b89cf7d42186d8832.json"}}, {"family": "Johansson", "given": "Linda", "initials": "L", "orcid": "0000-0001-7101-3165", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1af866dfcbe7406ab5785fee6fc740cf.json"}}], "type": "journal article", "published": "2023-04-07", "journal": {"title": "JMIR Aging", "issn": "2561-7605", "volume": "6", "pages": "e41950", "issn-l": null}, "abstract": "Harm from medications is a major patient safety challenge. Most adverse drug events arise when a medication is prescribed or reevaluated. Therefore, interventions in this area may improve patient safety. A medication plan, that is, a plan for continued treatment with medications, may support patient safety. Participation of patients in the design of health care products or services may improve patient safety. Co-design, as in the Double Diamond framework from the Design Council, England, can emphasize patient involvement. As the COVID-19 pandemic brought restrictions to face-to-face co-design approaches, interest in remote approaches increased. However, it is uncertain how best to perform remote co-design. Therefore, we explored a remote approach, which brought together older persons and health care professionals to co-design a medication plan prototype in the electronic health record, aiming to support patient safety.\n\nThis study aimed to describe how remote co-design was applied to create a medication plan prototype and to explore participants' experiences with this approach.\n\nWithin a case study design, we explored the experiences of a remote co-design initiative with 14 participants in a regional health care system in southern Sweden. Using descriptive statistics, quantitative data from questionnaires and web-based workshop timestamps were analyzed. A thematic analysis of the qualitative data gathered from workshops, interviews, and free-text responses to the survey questions was performed. Qualitative and quantitative data were compared side by side in the discussion.\n\nThe analysis of the questionnaires revealed that the participants rated the experiences of the co-design initiative very high. In addition, the balance between how much involved persons expressed their wishes and were listened to was considered very good. Marked timestamps from audio recordings showed that the workshops proceeded according to the plan. The thematic analysis yielded the following main themes: Everyone's perspective matters, Learning by sharing, and Mastering a digital space. The themes encompassed what helped to establish a permissive environment that allowed the participants to be involved and share viewpoints. There was a dynamic process of learning and understanding, realizing that despite different backgrounds, there was consensus about the requirements for a medication plan. The remote co-design process seemed appealing, by balancing opportunities and challenges and building an inviting, creative, and tolerant environment.\n\nParticipants experienced that the remote co-design initiative was inclusive of their perspectives and facilitated learning by sharing experiences. The Double Diamond framework was applicable in a digital context and supported the co-design process of the medication plan prototype. Remote co-design is still novel, but with attentiveness to power relations between all involved, this approach may increase opportunities for older persons and health care professionals to collaboratively design products or services that can improve patient safety.", "doi": "10.2196/41950", "pmid": "37027205", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "v6i1e41950"}], "notes": [], "created": "2023-04-20T17:30:17.565Z", "modified": "2023-04-20T17:30:17.755Z"}, {"entity": "publication", "iuid": "972c0def9aee4a7f9c9497925521940d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/972c0def9aee4a7f9c9497925521940d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/972c0def9aee4a7f9c9497925521940d"}}, "title": "Exploring workplace violence on surgical wards in Sweden: a cross-sectional study.", "authors": [{"family": "Jakobsson", "given": "Jenny", "initials": "J"}, {"family": "\u00d6rmon", "given": "Karin", "initials": "K"}, {"family": "Axelsson", "given": "Malin", "initials": "M"}, {"family": "Berthelsen", "given": "Hanne", "initials": "H"}], "type": "journal article", "published": "2023-04-07", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "volume": "22", "issue": "1", "pages": "106", "issn-l": null}, "abstract": "Workplace violence is a global threat to healthcare professionals' occupational health and safety and the situation has worsened during the COVID-19 pandemic. This study aimed to explore workplace violence directed against assistant and registered nurses working on surgical wards in Sweden.\n\nThis cross-sectional study was conducted in April 2022. Using a convenience sampling procedure, 198 assistant and registered nurses responded to an online questionnaire developed for this specific study. The questionnaire comprised 52 items and included, among other items, subscales from validated and previously used instruments. Data analysis included descriptive statistics, the chi-square test, and independent-samples t-test.\n\nThe most frequently reported type of workplace violence was humiliation (28.8%), followed by physical violence (24.2%), threats (17.7%), and unwanted sexual attention (12.1%). Patients and patients' visitors were reported as the main perpetrators of all kinds of exposure. Additionally, one third of the respondents had experienced humiliation from colleagues. Both threats and humiliation showed negative associations with work motivation and health (p < 0.05). Respondents classified as working in a high- or moderate-risk environment were more frequently exposed to threats (p = 0.025) and humiliation (p = 0.003). Meanwhile, half of the respondents were unaware of any action plans or training regarding workplace violence. However, of those who indicated that they had been exposed to workplace violence, the majority had received quite a lot or a lot of support, mainly from colleagues (range 70.8-80.8%).\n\nDespite a high prevalence of workplace violence, and especially of humiliating acts, there appeared to be low preparedness within the hospital organizations to prevent and/or handle such incidents. To improve these conditions, hospital organizations should place more emphasis on preventive measures as part of their systematic work environment management. To help inform such initiatives, it is suggested that future research should focus on the identification of suitable measures regarding different types of incidents, perpetrators, and settings.", "doi": "10.1186/s12912-023-01275-z", "pmid": "37029387", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10079490"}, {"db": "pii", "key": "10.1186/s12912-023-01275-z"}], "notes": [], "created": "2023-04-20T17:30:03.709Z", "modified": "2023-04-20T17:30:03.725Z"}, {"entity": "publication", "iuid": "654faa31ec7f4ec68d7c29f27107de55", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/654faa31ec7f4ec68d7c29f27107de55.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/654faa31ec7f4ec68d7c29f27107de55"}}, "title": "Study protocol of a phase 2, randomised, placebo-controlled, double-blind, adaptive, parallel group clinical study to evaluate the efficacy and safety of recombinant alpha-1-microglobulin in subjects at high risk for acute kidney injury following open-chest cardiac surgery (AKITA trial).", "authors": [{"family": "Mazer", "given": "C David", "initials": "CD", "orcid": "0000-0003-2566-4308", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4562eb6f8cb94b42ba42985a8e534bc4.json"}}, {"family": "Siadati-Fini", "given": "Niloufar", "initials": "N"}, {"family": "Boehm", "given": "Johannes", "initials": "J"}, {"family": "Wirth", "given": "Felix", "initials": "F"}, {"family": "Myjavec", "given": "Andrej", "initials": "A"}, {"family": "Brown", "given": "Craig D", "initials": "CD"}, {"family": "Koyner", "given": "Jay L", "initials": "JL"}, {"family": "Boening", "given": "Andreas", "initials": "A"}, {"family": "Engelman", "given": "Daniel T", "initials": "DT"}, {"family": "Larsson", "given": "Tobias E", "initials": "TE"}, {"family": "Renfurm", "given": "Ronny", "initials": "R"}, {"family": "de Varennes", "given": "Benoit", "initials": "B"}, {"family": "Noiseux", "given": "Nicolas", "initials": "N"}, {"family": "Thielmann", "given": "Matthias", "initials": "M"}, {"family": "Lamy", "given": "Andre", "initials": "A"}, {"family": "Laflamme", "given": "Maxime", "initials": "M"}, {"family": "von Groote", "given": "Thilo", "initials": "T", "orcid": "0000-0002-5287-1137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c09b4126b4124412b1f727eded281171.json"}}, {"family": "Ronco", "given": "Claudio", "initials": "C"}, {"family": "Zarbock", "given": "Alexander", "initials": "A", "orcid": "0000-0002-2124-1714", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6171146769d4287976ae737bbe755cd.json"}}], "type": "clinical trial protocol", "published": "2023-04-06", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "13", "issue": "4", "pages": "e068363", "issn-l": "2044-6055"}, "abstract": "Acute kidney injury (AKI) is a common complication after cardiac surgery (CS) and is associated with adverse short-term and long-term outcomes. Alpha-1-microglobulin (A1M) is a circulating glycoprotein with antioxidant, heme binding and mitochondrial-protective mechanisms. RMC-035 is a modified, more soluble, variant of A1M and has been proposed as a novel targeted therapeutic protein to prevent CS-associated AKI (CS-AKI). RMC-035 was considered safe and generally well tolerated when evaluated in four clinical phase 1 studies.\n\nThis is a phase 2, randomised, double-blind, adaptive design, parallel group clinical study that evaluates RMC-035 compared with placebo in approximately 268 cardiac surgical patients at high risk for CS-AKI. RMC-035 is administered as an intravenous infusion. In total, five doses will be given. Dosing is based on presurgery estimated glomerular filtration rate (eGFR), and will be either 1.3 or 0.65 mg/kg.The primary study objective is to evaluate whether RMC-035 reduces the incidence of postoperative AKI, and key secondary objectives are to evaluate whether RMC-035 improves postoperative renal function compared with placebo. A blinded interim analysis with potential sample size reassessment is planned once 134 randomised subjects have completed dosing. An independent data monitoring committee will evaluate safety and efficacy data at prespecified intervals throughout the trial. The study is a global multicentre study at approximately 30 sites.\n\nThe trial was approved by the joint ethics committee of the physician chamber Westfalen-Lippe and the University of M\u00fcnster (code '2021-778 f-A') and subsequently approved by the responsible ethics committees/relevant institutional review boards for the participating sites. The study is conducted in accordance with Good Clinical Practice, the Declaration of Helsinki and other applicable regulations. Results of this study will be published in a peer-reviewed scientific journal.\n\nNCT05126303.", "doi": "10.1136/bmjopen-2022-068363", "pmid": "37024249", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2022-068363"}, {"db": "ClinicalTrials.gov", "key": "NCT05126303"}], "notes": [], "created": "2023-04-12T16:47:54.133Z", "modified": "2023-04-12T16:47:54.232Z"}, {"entity": "publication", "iuid": "cedb318e6dfe4c94be75c5c45506300b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cedb318e6dfe4c94be75c5c45506300b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cedb318e6dfe4c94be75c5c45506300b"}}, "title": "Epitopes displayed in a cyclic peptide scaffold bind SARS-CoV-2 antibodies.", "authors": [{"family": "Eriksson", "given": "Camilla", "initials": "C"}, {"family": "Gunasekera", "given": "Sunithi", "initials": "S"}, {"family": "Muhammad", "given": "Taj", "initials": "T"}, {"family": "Zhang", "given": "Mingshu", "initials": "M"}, {"family": "Laur\u00e9n", "given": "Ida", "initials": "I"}, {"family": "Mangsbo", "given": "Sara M", "initials": "SM"}, {"family": "Lord", "given": "Martin", "initials": "M"}, {"family": "G\u00f6ransson", "given": "Ulf", "initials": "U"}], "type": "journal article", "published": "2023-04-06", "journal": {"title": "Chembiochem", "issn": "1439-7633", "issn-l": null, "volume": null, "issue": null, "pages": "e202300103"}, "abstract": "The SARS-CoV-2 virus that causes COVID-19 is a global health issue. The spread of the virus has resulted in more than six million deaths to date. The emergence of new viral strains highlights the importance of continuous surveillance of the SARS-CoV-2 virus, using timely and accurate diagnostic tools. Here, we used stable cyclic peptide scaffolds to present antigenic sequences derived from spike protein, reactive to SARS-CoV-2 antibodies. Using peptide sequences from different domains of SARS-CoV-2 spike protein, we grafted epitopes on the peptide scaffold sunflower trypsin inhibitor 1 (SFTI-1). These scaffold peptides were then used to develop a SARS-CoV-2 ELISA to detect SARS-CoV-2 antibodies in serum. We show that displaying epitopes in the scaffold improves reactivity overall. One of the scaffold peptides (S2_1146-1161_c) has reactivity equal to commercial assays, and shows diagnostic potential.", "doi": "10.1002/cbic.202300103", "pmid": "37021633", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-12T16:47:12.592Z", "modified": "2023-04-20T17:31:28.239Z"}, {"entity": "publication", "iuid": "fedaad814d10430d9d7328bf62b46739", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fedaad814d10430d9d7328bf62b46739.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fedaad814d10430d9d7328bf62b46739"}}, "title": "Electrochemical lateral-flow device for rapid COVID-19 antigen-diagnostic testing.", "authors": [{"family": "Deenin", "given": "Wanwisa", "initials": "W"}, {"family": "Yakoh", "given": "Abdulhadee", "initials": "A"}, {"family": "Pimpitak", "given": "Umaporn", "initials": "U"}, {"family": "Pasomsub", "given": "Ekawat", "initials": "E"}, {"family": "Rengpipat", "given": "Sirirat", "initials": "S"}, {"family": "Crespo", "given": "Gast\u00f3n A", "initials": "GA"}, {"family": "Chaiyo", "given": "Sudkate", "initials": "S"}], "type": "journal article", "published": "2023-04-06", "journal": {"title": "Bioelectrochemistry", "issn": "1878-562X", "volume": "152", "pages": "108438", "issn-l": null}, "abstract": "Antigen test kits (ATK) are extensively utilized for screening and diagnosing COVID-19 because they are easy to operate. However, ATKs exhibit poor sensitivity and cannot detect low concentrations of SARS-CoV-2. Herein, we present a new, highly sensitive, and selective device obtained by combining the principle of ATKs with electrochemical detection for COVID-19 diagnosis, which can be quantitatively assessed using a smartphone. An electrochemical test strip (E-test strip) was constructed by attaching a screen-printed electrode inside a lateral-flow device to exploit the remarkable binding affinity of SARS-CoV-2 antigen to ACE2. The ferrocene carboxylic acid attached to SARS-CoV-2 antibody acts as an electroactive species when it binds to SARS-CoV-2 antigen in the sample before it flows continuously to the ACE2-immobilization region on the electrode. Electrochemical-assay signal intensity on smartphones increased proportionally to the concentration of SARS-CoV-2 antigen (LOD = 2.98 pg/mL, under 12 min). Additionally, the application of the single-step E-test strip for COVID-19 screening was demonstrated using nasopharyngeal samples, and the results were consistent with those obtained using the gold standard (RT-PCR). Therefore, the sensor demonstrated excellent performance in assessing and screening COVID-19, and it can be used professionally to accurately verify diagnostic data while remaining rapid, simple, and inexpensive.", "doi": "10.1016/j.bioelechem.2023.108438", "pmid": "37054603", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10077809"}, {"db": "pii", "key": "S1567-5394(23)00075-0"}], "notes": [], "created": "2023-04-20T17:26:29.972Z", "modified": "2023-04-20T17:26:29.999Z"}, {"entity": "publication", "iuid": "4771f29f0a704723929281738b0b3549", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4771f29f0a704723929281738b0b3549.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4771f29f0a704723929281738b0b3549"}}, "title": "Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.", "authors": [{"family": "Matuozzo", "given": "Daniela", "initials": "D"}, {"family": "Talouarn", "given": "Estelle", "initials": "E"}, {"family": "Marchal", "given": "Astrid", "initials": "A"}, {"family": "Zhang", "given": "Peng", "initials": "P"}, {"family": "Manry", "given": "Jeremy", "initials": "J"}, {"family": "Seeleuthner", "given": "Yoann", "initials": "Y"}, {"family": "Zhang", "given": "Yu", "initials": "Y"}, {"family": "Bolze", "given": "Alexandre", "initials": "A"}, {"family": "Chaldebas", "given": "Matthieu", "initials": "M"}, {"family": "Milisavljevic", "given": "Baptiste", "initials": "B"}, {"family": "Gervais", "given": "Adrian", "initials": "A"}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Asano", "given": "Takaki", "initials": "T"}, {"family": "Bizien", "given": "Lucy", "initials": "L"}, {"family": "Barzaghi", "given": "Federica", "initials": "F"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Abou Tayoun", "given": "Ahmad", "initials": "A"}, {"family": "Aiuti", "given": "Alessandro", "initials": "A"}, {"family": "Alavi Darazam", "given": "Ilad", "initials": "I"}, {"family": "Allende", "given": "Luis M", "initials": "LM"}, {"family": "Alonso-Arias", "given": "Rebeca", "initials": "R"}, {"family": "Arias", "given": "Andr\u00e9s Augusto", "initials": "AA"}, {"family": "Aytekin", "given": "Gokhan", "initials": "G"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Bondesan", "given": "Simone", "initials": "S"}, {"family": "Bryceson", "given": "Yenan T", "initials": "YT"}, {"family": "Bustos", "given": "Ingrid G", "initials": "IG"}, {"family": "Cabrera-Marante", "given": "Oscar", "initials": "O"}, {"family": "Carcel", "given": "Sheila", "initials": "S"}, {"family": "Carrera", "given": "Paola", "initials": "P"}, {"family": "Casari", "given": "Giorgio", "initials": "G"}, {"family": "Cha\u00efbi", "given": "Khalil", "initials": "K"}, {"family": "Colobran", "given": "Roger", "initials": "R"}, {"family": "Condino-Neto", "given": "Antonio", "initials": "A"}, {"family": "Covill", "given": "Laura E", "initials": "LE"}, {"family": "Delmonte", "given": "Ottavia M", "initials": "OM"}, {"family": "El Zein", "given": "Loubna", "initials": "L"}, {"family": "Flores", "given": "Carlos", "initials": "C"}, {"family": "Gregersen", "given": "Peter K", "initials": "PK"}, {"family": "Gut", "given": "Marta", "initials": "M"}, {"family": "Haerynck", "given": "Filomeen", "initials": "F"}, {"family": "Halwani", "given": "Rabih", "initials": "R"}, {"family": "Hancerli", "given": "Selda", "initials": "S"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Hatipo\u011flu", "given": "Nevin", "initials": "N"}, {"family": "Karbuz", "given": "Adem", "initials": "A"}, {"family": "Keles", "given": "Sevgi", "initials": "S"}, {"family": "Kyheng", "given": "Christ\u00e8le", "initials": "C"}, {"family": "Leon-Lopez", "given": "Rafael", "initials": "R"}, {"family": "Franco", "given": "Jose Luis", "initials": "JL"}, {"family": "Mansouri", "given": "Davood", "initials": "D"}, {"family": "Martinez-Picado", "given": "Javier", "initials": "J"}, {"family": "Metin Akcan", "given": "Ozge", "initials": "O"}, {"family": "Migeotte", "given": "Isabelle", "initials": "I"}, {"family": "Morange", "given": "Pierre-Emmanuel", "initials": "PE"}, {"family": "Morelle", "given": "Guillaume", "initials": "G"}, {"family": "Martin-Nalda", "given": "Andrea", "initials": "A"}, {"family": "Novelli", "given": "Giuseppe", "initials": "G"}, {"family": "Novelli", "given": "Antonio", "initials": "A"}, {"family": "Ozcelik", "given": "Tayfun", "initials": "T"}, {"family": "Palabiyik", "given": "Figen", "initials": "F"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}, {"family": "de Diego", "given": "Rebeca P\u00e9rez", "initials": "RP"}, {"family": "Planas-Serra", "given": "Laura", "initials": "L"}, {"family": "Pleguezuelo", "given": "Daniel E", "initials": "DE"}, {"family": "Prando", "given": "Carolina", "initials": "C"}, {"family": "Pujol", "given": "Aurora", "initials": "A"}, {"family": "Reyes", "given": "Luis Felipe", "initials": "LF"}, {"family": "Rivi\u00e8re", "given": "Jacques G", "initials": "JG"}, {"family": "Rodriguez-Gallego", "given": "Carlos", "initials": "C"}, {"family": "Rojas", "given": "Julian", "initials": "J"}, {"family": "Rovere-Querini", "given": "Patrizia", "initials": "P"}, {"family": "Schl\u00fcter", "given": "Agatha", "initials": "A"}, {"family": "Shahrooei", "given": "Mohammad", "initials": "M"}, {"family": "Sobh", "given": "Ali", "initials": "A"}, {"family": "Soler-Palacin", "given": "Pere", "initials": "P"}, {"family": "Tandjaoui-Lambiotte", "given": "Yacine", "initials": "Y"}, {"family": "Tipu", "given": "Imran", "initials": "I"}, {"family": "Tresoldi", "given": "Cristina", "initials": "C"}, {"family": "Troya", "given": "Jesus", "initials": "J"}, {"family": "van de Beek", "given": "Diederik", "initials": "D"}, {"family": "Zatz", "given": "Mayana", "initials": "M"}, {"family": "Zawadzki", "given": "Pawel", "initials": "P"}, {"family": "Al-Muhsen", "given": "Saleh Zaid", "initials": "SZ"}, {"family": "Alosaimi", "given": "Mohammed Faraj", "initials": "MF"}, {"family": "Alsohime", "given": "Fahad M", "initials": "FM"}, {"family": "Baris-Feldman", "given": "Hagit", "initials": "H"}, {"family": "Butte", "given": "Manish J", "initials": "MJ"}, {"family": "Constantinescu", "given": "Stefan N", "initials": "SN"}, {"family": "Cooper", "given": "Megan A", "initials": "MA"}, {"family": "Dalgard", "given": "Clifton L", "initials": "CL"}, {"family": "Fellay", "given": "Jacques", "initials": "J"}, {"family": "Heath", "given": "James R", "initials": "JR"}, {"family": "Lau", "given": "Yu-Lung", "initials": "YL"}, {"family": "Lifton", "given": "Richard P", "initials": "RP"}, {"family": "Maniatis", "given": "Tom", "initials": "T"}, {"family": "Mogensen", "given": "Trine H", "initials": "TH"}, {"family": "von Bernuth", "given": "Horst", "initials": "H"}, {"family": "Lermine", "given": "Alban", "initials": "A"}, {"family": "Vidaud", "given": "Michel", "initials": "M"}, {"family": "Boland", "given": "Anne", "initials": "A"}, {"family": "Deleuze", "given": "Jean-Fran\u00e7ois", "initials": "JF"}, {"family": "Nussbaum", "given": "Robert", "initials": "R"}, {"family": "Kahn-Kirby", "given": "Amanda", "initials": "A"}, {"family": "Mentre", "given": "France", "initials": "F"}, {"family": "Tubiana", "given": "Sarah", "initials": "S"}, {"family": "Gorochov", "given": "Guy", "initials": "G"}, {"family": "Tubach", "given": "Florence", "initials": "F"}, {"family": "Hausfater", "given": "Pierre", "initials": "P"}, {"family": "COVID Human Genetic Effort", "given": "", "initials": ""}, {"family": "COVIDeF Study Group", "given": "", "initials": ""}, {"family": "French COVID Cohort Study Group", "given": "", "initials": ""}, {"family": "CoV-Contact Cohort", "given": "", "initials": ""}, {"family": "COVID-STORM Clinicians", "given": "", "initials": ""}, {"family": "COVID Clinicians", "given": "", "initials": ""}, {"family": "Orchestra Working Group", "given": "", "initials": ""}, {"family": "Amsterdam UMC Covid-19 Biobank", "given": "", "initials": ""}, {"family": "NIAID-USUHS COVID Study Group", "given": "", "initials": ""}, {"family": "Meyts", "given": "Isabelle", "initials": "I"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Puel", "given": "Anne", "initials": "A"}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD"}, {"family": "Boisson-Dupuis", "given": "Stephanie", "initials": "S"}, {"family": "Su", "given": "Helen C", "initials": "HC"}, {"family": "Boisson", "given": "Bertrand", "initials": "B"}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL"}, {"family": "Zhang", "given": "Qian", "initials": "Q"}, {"family": "Abel", "given": "Laurent", "initials": "L"}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5369fe152ac94b5a81d4f913d85940a7.json"}}], "type": "journal article", "published": "2023-04-05", "journal": {"title": "Genome Med", "issn": "1756-994X", "issn-l": null, "volume": "15", "issue": "1", "pages": "22"}, "abstract": "We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases.\n\nWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.\n\nNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P = 1.1 \u00d7 10-4) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3-8.2], P = 2.1 \u00d7 10-4). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1-2635.4], P = 3.4 \u00d7 10-3), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3-8.4], P = 7.7 \u00d7 10-8). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 \u00d7 10-5).\n\nRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.", "doi": "10.1186/s13073-023-01173-8", "pmid": "37020259", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10074346"}, {"db": "pii", "key": "10.1186/s13073-023-01173-8"}, {"db": "ClinicalTrials.gov", "key": "NCT04262921"}, {"db": "ClinicalTrials.gov", "key": "NCT04259892"}, {"db": "ClinicalTrials.gov", "key": "NCT04352348"}], "notes": [], "created": "2023-04-12T16:45:00.367Z", "modified": "2023-06-19T15:33:16.774Z"}, {"entity": "publication", "iuid": "ebd0517b643c4bd296f4066e7bd2a421", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ebd0517b643c4bd296f4066e7bd2a421.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ebd0517b643c4bd296f4066e7bd2a421"}}, "title": "Progress in vaccine development for infectious diseases-a Keystone Symposia report.", "authors": [{"family": "Cable", "given": "Jennifer", "initials": "J"}, {"family": "Graham", "given": "Barney S", "initials": "BS"}, {"family": "Koup", "given": "Richard A", "initials": "RA"}, {"family": "Seder", "given": "Robert A", "initials": "RA"}, {"family": "Karik\u00f3", "given": "Katalin", "initials": "K"}, {"family": "Pardi", "given": "Norbert", "initials": "N"}, {"family": "Barouch", "given": "Dan H", "initials": "DH"}, {"family": "Sharma", "given": "Bhawna", "initials": "B"}, {"family": "Rauch", "given": "Susanne", "initials": "S"}, {"family": "Nachbagauer", "given": "Raffael", "initials": "R"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Schotsaert", "given": "Michael", "initials": "M"}, {"family": "Ellebedy", "given": "Ali H", "initials": "AH"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "Irvine", "given": "Darrell J", "initials": "DJ"}, {"family": "Pilkington", "given": "Emily", "initials": "E"}, {"family": "Tahtinen", "given": "Siri", "initials": "S"}, {"family": "Thompson", "given": "Elizabeth A", "initials": "EA"}, {"family": "Feraoun", "given": "Yanis", "initials": "Y"}, {"family": "King", "given": "Neil P", "initials": "NP"}, {"family": "Saunders", "given": "Kevin", "initials": "K"}, {"family": "Alter", "given": "Galit", "initials": "G"}, {"family": "Moin", "given": "Syed M", "initials": "SM"}, {"family": "Sliepen", "given": "Kwinten", "initials": "K"}, {"family": "Hedestam", "given": "Gunilla B Karlsson", "initials": "GBK"}, {"family": "Wardemann", "given": "Hedda", "initials": "H"}, {"family": "Pulendran", "given": "Bali", "initials": "B"}, {"family": "Doria-Rose", "given": "Nicole A", "initials": "NA"}, {"family": "He", "given": "Wan-Ting", "initials": "WT"}, {"family": "Juno", "given": "Jennifer A", "initials": "JA"}, {"family": "Ataca", "given": "Sila", "initials": "S"}, {"family": "Wheatley", "given": "Adam K", "initials": "AK"}, {"family": "McLellan", "given": "Jason S", "initials": "JS"}, {"family": "Walker", "given": "Laura M", "initials": "LM"}, {"family": "Lederhofer", "given": "Julia", "initials": "J"}, {"family": "Lindesmith", "given": "Lisa C", "initials": "LC"}, {"family": "Wille", "given": "Holger", "initials": "H"}, {"family": "Hotez", "given": "Peter J", "initials": "PJ"}, {"family": "Bekker", "given": "Linda-Gail", "initials": "LG"}], "type": "journal article", "published": "2023-04-05", "journal": {"title": "Ann N Y Acad Sci", "issn": "1749-6632", "issn-l": null}, "abstract": "The COVID-19 pandemic has taught us many things, among the most important of which is that vaccines are one of the cornerstones of public health that help make modern longevity possible. While several different vaccines have been successful at stemming the morbidity and mortality associated with various infectious diseases, many pathogens/diseases remain recalcitrant to the development of effective vaccination. Recent advances in vaccine technology, immunology, structural biology, and other fields may yet yield insight that will address these diseases; they may also help improve societies' preparedness for future pandemics. On June 1-4, 2022, experts in vaccinology from academia, industry, and government convened for the Keystone symposium \"Progress in Vaccine Development for Infectious Diseases\" to discuss state-of-the-art technologies, recent advancements in understanding vaccine-mediated immunity, and new aspects of antigen design to aid vaccine effectiveness.", "doi": "10.1111/nyas.14975", "pmid": "37020354", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-04-12T16:57:16.013Z", "modified": "2023-04-12T16:57:16.028Z"}, {"entity": "publication", "iuid": "e9de182c54464427a9bcf42df7f187b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e9de182c54464427a9bcf42df7f187b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e9de182c54464427a9bcf42df7f187b0"}}, "title": "The impact of immunomodulating treatment on the immunogenicity of COVID-19 vaccines in patients with immune-mediated inflammatory rheumatic diseases compared to healthy controls. A Swedish nationwide study (COVID19-REUMA).", "authors": [{"family": "Frodlund", "given": "Martina", "initials": "M"}, {"family": "Nived", "given": "Per", "initials": "P"}, {"family": "Chatzidionysiou", "given": "Aikaterini", "initials": "A"}, {"family": "S\u00f6dergren", "given": "Anna", "initials": "A"}, {"family": "Klingberg", "given": "Eva", "initials": "E"}, {"family": "Bengtsson", "given": "Anders", "initials": "A"}, {"family": "Hansson", "given": "Monika", "initials": "M"}, {"family": "Olsson", "given": "Sophie", "initials": "S"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Klareskog", "given": "Lars", "initials": "L"}, {"family": "Kapetanovic", "given": "Meliha C", "initials": "MC"}], "type": "journal article", "published": "2023-04-04", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null}, "abstract": "To elucidate antibody responses after the second and third dose of COVID-19 vaccine in patients with inflammatory rheumatic diseases (IRD) treated with biologic/targeted disease modifying anti-rheumatic drugs (b/ts DMARDs).\n\nAntibody levels to antigens representing spike full length protein and spike S1 were measured before vaccination, 2-12 weeks after the second dose, before and after the third dose using multiplex bead-based serology assay. Positive antibody response was defined as antibody levels over cut off (seropositivity) in seronegative individuals or \u2265 4-fold increase in antibodies in individuals seropositive for both spike proteins.\n\nPatients (n = 414) receiving b/ts DMARDs (283 had arthritis, 75 systemic vasculitis and 56 other autoimmune diseases) and controls (n = 61) from five Swedish regions participated. Treatments groups were: rituximab (n = 145); abatacept (n = 22); Interleukin 6 receptor inhibitors [IL6i (n = 79)]; JAnus Kinase Inhibitors [JAKi (n = 58)], Tumour Necrosis Factor inhibitor [TNFi (n = 68)] and Interleukin12/23/17 inhibitors [IL12/23/17i (n = 42)]. Percentage of patients with positive antibody response after two doses was significantly lower in rituximab (33,8%) and abatacept (40,9%) (p < 0,001) but not in IL12/23/17i, TNFi or JAKi groups compared to controls (80,3%). Higher age, rituximab treatment and shorter time between last rituximab course and vaccination predicted impaired antibody response. Antibody levels collected 21-40 weeks after second dose decreased significantly (IL6i: p = 0,02; other groups: p < 0,001) compared to levels at 2-12 week but most participants remained seropositive. Proportion of patients with positive antibody response increased after third dose but was still significantly lower in rituximab (p < 0,001).\n\nOlder individuals and patients on maintenance rituximab have an impaired response after two doses of COVID-19 vaccine which improves if the time between last rituximab course and vaccination extends and also after an additional vaccine dose. Rituximab patients should be prioritized for booster vaccine doses. TNFi, JAKi and IL12/23/17i does not diminished humoral response to primary and an additional vaccination.", "doi": "10.1016/j.vaccine.2023.03.065", "pmid": "37076360", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(23)00372-9"}], "notes": [], "created": "2023-04-20T17:19:58.707Z", "modified": "2023-04-20T17:19:58.711Z"}, {"entity": "publication", "iuid": "cfbc238647cc44adbd0dec991239d3af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfbc238647cc44adbd0dec991239d3af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfbc238647cc44adbd0dec991239d3af"}}, "title": "Risk of venous thromboembolism in patients with COVID-19 during 2020; a retrospective cross-sectional study in a Swedish health care system.", "authors": [{"family": "Wretborn", "given": "Jens", "initials": "J"}, {"family": "J\u00f6rg", "given": "Matthias", "initials": "M"}, {"family": "Benjaminsson Nyberg", "given": "Patrik", "initials": "P"}, {"family": "Wilhelms", "given": "Daniel B", "initials": "DB"}], "type": "observational study", "published": "2023-04-04", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "13", "issue": "1", "pages": "5469", "issn-l": "2045-2322"}, "abstract": "To establish the impact of COVID-19 on the pre-test probability for VTE in patients with suspected VTE. This was a retrospective, observational, cross-sectional study of patients 18 years and older undergoing diagnostic tests for VTE in an integrated healthcare system covering a population of 465,000 during the calendar year of 2020. We adjusted for risk factors such as age, sex, previous VTE, ongoing anticoagulant treatment, malignancy, Charlson score, ward care, ICU care and wave of COVID-19. In total, 303 of 5041 patients had a positive diagnosis of COVID-19 around the time of investigation. The prevalence of VTE in COVID-positive patients was 10.2% (36/354), 14.7% (473/3219) in COVID-19 negative patients, and 15.6% (399/2589) in patients without a COVID-19 test. A COVID-positive status was not associated with an increased risk for VTE (crude odds ratio 0.64, 95% CI 0.45-0.91, adjusted odds ratio 0.46, 95%CI 0.19-1.16). We found no increased VTE risk in COVID-positive patients. This indicates that COVID-19 status should not influence VTE workup.The study was pre-registered on May 26, 2020 at ClinicalTrials.gov with identifier NCT04400877.", "doi": "10.1038/s41598-023-32637-x", "pmid": "37015984", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10071240"}, {"db": "pii", "key": "10.1038/s41598-023-32637-x"}, {"db": "ClinicalTrials.gov", "key": "NCT04400877"}], "notes": [], "created": "2023-04-20T17:34:09.863Z", "modified": "2023-04-20T17:34:31.386Z"}, {"entity": "publication", "iuid": "8fb56fd42b8c40bab2e6d38faf82c335", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8fb56fd42b8c40bab2e6d38faf82c335.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8fb56fd42b8c40bab2e6d38faf82c335"}}, "title": "The influence of meteorological factors on COVID-19 spread in Italy during the first and second wave.", "authors": [{"family": "Balboni", "given": "Erica", "initials": "E"}, {"family": "Filippini", "given": "Tommaso", "initials": "T"}, {"family": "Rothman", "given": "Kenneth J", "initials": "KJ"}, {"family": "Costanzini", "given": "Sofia", "initials": "S"}, {"family": "Bellino", "given": "Stefania", "initials": "S"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Brusaferro", "given": "Silvio", "initials": "S"}, {"family": "Ferrari", "given": "Fabrizio", "initials": "F"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}, {"family": "Teggi", "given": "Sergio", "initials": "S"}, {"family": "Vinceti", "given": "Marco", "initials": "M"}], "type": "journal article", "published": "2023-04-03", "journal": {"title": "Environ Res", "issn": "1096-0953", "volume": "228", "pages": "115796", "issn-l": "0013-9351"}, "abstract": "The relation between meteorological factors and COVID-19 spread remains uncertain, particularly with regard to the role of temperature, relative humidity and solar ultraviolet (UV) radiation. To assess this relation, we investigated disease spread within Italy during 2020. The pandemic had a large and early impact in Italy, and during 2020 the effects of vaccination and viral variants had not yet complicated the dynamics. We used non-linear, spline-based Poisson regression of modeled temperature, UV and relative humidity, adjusting for mobility patterns and additional confounders, to estimate daily rates of COVID-19 new cases, hospital and intensive care unit admissions, and deaths during the two waves of the pandemic in Italy during 2020. We found little association between relative humidity and COVID-19 endpoints in both waves, whereas UV radiation above 40 kJ/m2 showed a weak inverse association with hospital and ICU admissions in the first wave, and a stronger relation with all COVID-19 endpoints in the second wave. Temperature above 283 K (10 \u00b0C/50 \u00b0F) showed a strong non-linear negative relation with COVID-19 endpoints, with inconsistent relations below this cutpoint in the two waves. Given the biological plausibility of a relation between temperature and COVID-19, these data add support to the proposition that temperature above 283 K, and possibly high levels of solar UV radiation, reduced COVID-19 spread.", "doi": "10.1016/j.envres.2023.115796", "pmid": "37019296", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10069087"}, {"db": "pii", "key": "S0013-9351(23)00588-1"}], "notes": [], "created": "2023-04-20T17:32:35.870Z", "modified": "2023-04-20T17:32:35.873Z"}, {"entity": "publication", "iuid": "247606a2b6ef4131a55e51ce4a162a24", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/247606a2b6ef4131a55e51ce4a162a24.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/247606a2b6ef4131a55e51ce4a162a24"}}, "title": "Missed opportunities in using lessons from HIV response to combat COVID-19 - looking back while preparing for the next pandemic.", "authors": [{"family": "Panakadan", "given": "Salil", "initials": "S"}, {"family": "Gun", "given": "Arkaprabha", "initials": "A"}, {"family": "Sarkar", "given": "Swarup", "initials": "S"}], "type": "journal article", "published": "2023-04-03", "journal": {"title": "Indian J Med Res", "issn": "0971-5916", "issn-l": null}, "abstract": null, "doi": "10.4103/ijmr.ijmr_313_23", "pmid": "37006024", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "373426"}], "notes": [], "created": "2023-04-20T17:39:44.490Z", "modified": "2023-04-20T17:39:44.507Z"}, {"entity": "publication", "iuid": "e9fd703334084370af67f4e335bed340", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e9fd703334084370af67f4e335bed340.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e9fd703334084370af67f4e335bed340"}}, "title": "Flares after COVID-19 infection in patients with idiopathic inflammatory myopathies: results from the COVAD study.", "authors": [{"family": "Ali", "given": "Sasha Saadia", "initials": "SS"}, {"family": "R", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Saha", "given": "Sreoshy", "initials": "S", "orcid": "0000-0001-6745-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00238845dd4833ae51ffb75e2fe144.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Jagtap", "given": "Kshitij", "initials": "K", "orcid": "0000-0003-2729-737X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822b9da98e5d4eb2975ff97fe484933f.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Edgar Gracia-Ramos", "given": "Abraham", "initials": "A", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Chen", "given": "Yi Ming", "initials": "YM", "orcid": "0000-0001-7593-3065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/795f1bf1d4824521a3301f7c50f62bc4.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-0986-8354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2e6226ae5e7427fbf52e180dd14e28f.json"}}, {"family": "Patel", "given": "Aarat", "initials": "A"}, {"family": "Pauling", "given": "John D", "initials": "JD", "orcid": "0000-0002-2793-2364", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e37709273d404d17a88c7c850777b99f.json"}}, {"family": "Wincup", "given": "Chris", "initials": "C", "orcid": "0000-0002-8742-8311", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a674f02e7f7f45f58167eb24f81502f3.json"}}, {"family": "Barman", "given": "Bhupen", "initials": "B", "orcid": "0000-0002-5433-1310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7747785ec5fa4743bc70bd20fbca10fd.json"}}, {"family": "Zamora Tehozol", "given": "Erick Adrian", "initials": "EA", "orcid": "0000-0002-7888-3961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a55c695ac4f4003993a2f511cca7739.json"}}, {"family": "Rojas Serrano", "given": "Jorge", "initials": "J", "orcid": "0000-0001-6980-7898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/225fd8b396ac40f4a77f1ec229c086b6.json"}}, {"family": "La Torre", "given": "Ignacio Garc\u00eda-De", "initials": "IG", "orcid": "0000-0002-9261-678X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/086b85d66fb84b50bd51bbe5a979dfe3.json"}}, {"family": "Colunga-Pedraza", "given": "Iris J", "initials": "IJ", "orcid": "0000-0002-2786-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50e46ef2c7f44b39a1d28fea6a8e621d.json"}}, {"family": "Merayo-Chalico", "given": "Javier", "initials": "J", "orcid": "0000-0002-5870-0523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d74c0ab33cbe4df586e1a1add37d0e65.json"}}, {"family": "Chibuzo", "given": "Okwara Celestine", "initials": "OC"}, {"family": "Katchamart", "given": "Wanruchada", "initials": "W", "orcid": "0000-0002-8952-5967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9439933b38fb49aca8fdbb5038ff603c.json"}}, {"family": "Goo", "given": "Phonpen Akawatcharangura", "initials": "PA"}, {"family": "Shumnalieva", "given": "Russka", "initials": "R", "orcid": "0000-0003-2321-6536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/933232cd7feb48ee81b5971f01f52e23.json"}}, {"family": "Hoff", "given": "Leonardo Santos", "initials": "LS", "orcid": "0000-0002-2083-4796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1df7af8caf024ca39c57278fdf18c766.json"}}, {"family": "El Kibbi", "given": "Lina", "initials": "L", "orcid": "0000-0003-1710-9996", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11bb4fc524264c6897dec9642a0ef7cd.json"}}, {"family": "Halabi", "given": "Hussein", "initials": "H", "orcid": "0000-0002-5174-8292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb337090a5ab4461a07e8620bee1b4b9.json"}}, {"family": "Vaidya", "given": "Binit", "initials": "B", "orcid": "0000-0002-4840-8924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b2296d53fe14fc7a8415f26e03e1944.json"}}, {"family": "Shaharir", "given": "Syahrul Sazliyana", "initials": "SS", "orcid": "0000-0002-9068-8114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1e6310979d44d58b548c61c733412af.json"}}, {"family": "Hasan", "given": "A T M Tanveer", "initials": "ATMT", "orcid": "0000-0002-5332-3319", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ffdb3329292438fac4005923ee79012.json"}}, {"family": "Dey", "given": "Dzifa", "initials": "D", "orcid": "0000-0002-3339-5112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2615e43aeba34a0585679bdd14a1a324.json"}}, {"family": "Guti\u00e9rrez", "given": "Carlos Enrique Toro", "initials": "CET", "orcid": "0000-0002-6084-7049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/980e455c5d114caaaefb6e0b55eaa3b3.json"}}, {"family": "Caballero-Uribe", "given": "Carlo Vinicio", "initials": "CV", "orcid": "0000-0002-9845-8620", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42d86c9923424f9a804bab4580b993c3.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "COVAD study group", "given": "", "initials": ""}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}], "type": "journal article", "published": "2023-04-02", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "issn-l": null}, "abstract": null, "doi": "10.1093/rheumatology/kead149", "pmid": "37004201", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7099604"}], "notes": [], "created": "2023-04-20T17:40:10.413Z", "modified": "2023-04-20T17:40:11.317Z"}, {"entity": "publication", "iuid": "229dabd823ed479fb027ca750381cb48", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/229dabd823ed479fb027ca750381cb48.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/229dabd823ed479fb027ca750381cb48"}}, "title": "Setting an Agenda: Results of a Consensus Process on Research Directions in Distance Simulation.", "authors": [{"family": "Gross", "given": "Isabel T", "initials": "IT"}, {"family": "Clapper", "given": "Timothy C", "initials": "TC"}, {"family": "Ramachandra", "given": "Geethanjali", "initials": "G"}, {"family": "Thomas", "given": "Anita", "initials": "A"}, {"family": "Ades", "given": "Anne", "initials": "A"}, {"family": "Walsh", "given": "Barbara", "initials": "B"}, {"family": "Kreuzer", "given": "Florian", "initials": "F"}, {"family": "Elkin", "given": "Rachel", "initials": "R"}, {"family": "Wagner", "given": "Michael", "initials": "M"}, {"family": "Whitfill", "given": "Travis", "initials": "T"}, {"family": "Chang", "given": "Todd P", "initials": "TP"}, {"family": "Duff", "given": "Jonathan P", "initials": "JP"}, {"family": "Deutsch", "given": "Ellen S", "initials": "ES"}, {"family": "Loellgen", "given": "Ruth M", "initials": "RM"}, {"family": "Palaganas", "given": "Janice C", "initials": "JC"}, {"family": "Fayyaz", "given": "Jabeen", "initials": "J"}, {"family": "Kessler", "given": "David", "initials": "D"}, {"family": "Calhoun", "given": "Aaron W", "initials": "AW"}], "type": "review", "published": "2023-04-01", "journal": {"title": "Simul Healthc", "issn": "1559-713X", "volume": "18", "issue": "2", "pages": "100-107", "issn-l": null}, "abstract": "The COVID-19 pandemic forced rapid implementation and refinement of distance simulation methodologies in which participants and/or facilitators are not physically colocated. A review of the distance simulation literature showed that heterogeneity in many areas (including nomenclature, methodology, and outcomes) limited the ability to identify best practice. In April 2020, the Healthcare Distance Simulation Collaboration was formed with the goal of addressing these issues. The aim of this study was to identify future research priorities in the field of distance simulation using data derived from this summit.\n\nThis study analyzed textual data gathered during the consensus process conducted at the inaugural Healthcare Distance Simulation Summit to explore participant perceptions of the most pressing research questions regarding distance simulation. Participants discussed education and patient safety standards, simulation facilitators and barriers, and research priorities. Data were qualitatively analyzed using an explicitly constructivist thematic analysis approach, resulting in the creation of a theoretical framework.\n\nOur sample included 302 participants who represented 29 countries. We identified 42 codes clustered within 4 themes concerning key areas in which further research into distance simulation is needed: (1) safety and acceptability, (2) educational/foundational considerations, (3) impact, and (4) areas of ongoing exploration. Within each theme, pertinent research questions were identified and categorized.\n\nDistance simulation presents several challenges and opportunities. Research around best practices, including educational foundation and psychological safety, are especially important as is the need to determine outcomes and long-term effects of this emerging field.", "doi": "10.1097/SIH.0000000000000663", "pmid": "36989108", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "01266021-202304000-00004"}], "notes": [], "created": "2023-04-21T15:55:55.001Z", "modified": "2023-04-21T15:55:55.021Z"}, {"entity": "publication", "iuid": "f5cdf5e7e60f43279f920149fd093bdc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f5cdf5e7e60f43279f920149fd093bdc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f5cdf5e7e60f43279f920149fd093bdc"}}, "title": "Outcome of SARS-CoV2 infection in hematopoietic stem cell transplant recipients for autoimmune diseases.", "authors": [{"family": "Greco", "given": "Raffaella", "initials": "R"}, {"family": "Snowden", "given": "John A", "initials": "JA"}, {"family": "Knelange", "given": "Nina Simone", "initials": "NS"}, {"family": "Tridello", "given": "Gloria", "initials": "G"}, {"family": "Cacciatore", "given": "Carlotta", "initials": "C"}, {"family": "Xhaard", "given": "Alienor", "initials": "A"}, {"family": "Ciceri", "given": "Fabio", "initials": "F"}, {"family": "Collin", "given": "Matthew", "initials": "M"}, {"family": "Ferra", "given": "Christelle", "initials": "C"}, {"family": "De Becker", "given": "Ann", "initials": "A"}, {"family": "Badoglio", "given": "Manuela", "initials": "M"}, {"family": "Averbuch", "given": "Dina", "initials": "D"}, {"family": "Alexander", "given": "Tobias", "initials": "T"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "De la Camara", "given": "Rafael", "initials": "R"}, {"family": "European Society for Blood and Marrow Transplantation (EBMT) COVID19 Task Force, Autoimmune Diseases Working Party (ADWP) and Infectious Diseases Working Party (IDWP)", "given": "", "initials": ""}], "type": "multicenter study", "published": "2023-04-00", "journal": {"title": "J Autoimmun", "issn": "1095-9157", "volume": "136", "pages": "103024", "issn-l": null}, "abstract": "Hematopoietic stem cell transplant (HSCT) recipients may be at high risk of mortality from coronavirus disease 2019 (COVID-19). However, specific data on COVID-19 after treatment with HSCT in patients affected by autoimmune diseases (ADs) are still lacking. In this multicenter observational study of the European Society for Blood and Marrow Transplantation (EBMT), clinical data on COVID-19 in 11 patients affected by severe ADs treated with HSCT (n = 3 allogeneic transplant; n = 8 autologous transplant) are reported. All patients were symptomatic during the initial phase of the SARS-CoV-2 infection. At screening, 5 patients reported upper respiratory symptoms, 3 patients had cough without oxygen requirement, and 6 patients exhibited extra-pulmonary symptoms. Four cases developed a lower respiratory tract disease (LRTD). Hospitalization was required in 6 cases, without necessity of intensive care unit (ICU) admission and/or ventilation/supplemental oxygen. Different interventions were adopted: remdesivir (n = 1), nirmatrelvir/ritonavir (n = 1), sotrovimab (n = 1), immunoglobulins (n = 1). At last follow-up, all patients are alive and had resolution of the infection. The current analysis describing the mild-moderate course of COVID-19 in transplant recipients affected by ADs, similar to the course observed in ADs under standard treatments, provides useful information to support the delivery of HSCT programs in this field. Vaccination and new treatments available for SARS-CoV-2 may be useful to further minimize the risk of infection.", "doi": "10.1016/j.jaut.2023.103024", "pmid": "37001437", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9977622"}, {"db": "pii", "key": "S0896-8411(23)00033-1"}], "notes": [], "created": "2023-04-20T17:41:50.640Z", "modified": "2023-04-20T17:41:50.654Z"}, {"entity": "publication", "iuid": "6084019b59d24fceb0530a9ee8bfd452", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6084019b59d24fceb0530a9ee8bfd452.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6084019b59d24fceb0530a9ee8bfd452"}}, "title": "Non-communicable disease policy implementation from 2014 to 2021: a repeated cross-sectional analysis of global policy data for 194 countries.", "authors": [{"family": "Allen", "given": "Luke N", "initials": "LN"}, {"family": "Wigley", "given": "Simon", "initials": "S"}, {"family": "Holmer", "given": "Hampus", "initials": "H"}, {"family": "Barlow", "given": "Pepita", "initials": "P"}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "Lancet Glob Health", "issn": "2214-109X", "volume": "11", "issue": "4", "pages": "e525-e533", "issn-l": null}, "abstract": "Non-communicable diseases (NCDs) are the world's leading cause of death and disability. Global implementation of WHO-recommended NCD policies has been increasing with time, but in 2019 fewer than half of these policies had been implemented globally. In 2022, WHO released updated data on NCD policy implementation, on the basis of surveys conducted in 2021 during the COVID-19 pandemic. We sought to examine whether the trajectory of global policy implementation changed during this period.\n\nIn this repeated cross-sectional analysis, we used data from the 2015, 2017, 2020, and 2022 WHO progress monitors to calculate NCD policy implementation scores for all 194 WHO member states. We used Welch's ANOVA and Games-Howell post-hoc pairwise testing to examine changes in mean implementation scores for 19 WHO-recommended NCD policies, with assessment at the global, geographical, geopolitical, and country-income levels. We collated sales data on tobacco, alcohol, and junk foods to examine the association between changes in sales and the predicted probability of implementation of policies targeting these products. We also calculated the Corporate Financial Influence Index (CFII) for each country, which was used to assess the association between corporate influence and policy implementation. We used logistic regression to assess the relationship between product sales and the probability of implementing related policies. The relationship between CFII and policy implementation was assessed with Pearson's correlation analysis and random-effects multivariate regression.\n\nAcross the 194 countries, in the years preceding publication of each progress monitor, mean total policy implementation score (out of a potential 18\u00b70) was 7\u00b70 (SD 3\u00b75) in 2014, 8\u00b72 (3\u00b75) in 2016, 8\u00b76 (3\u00b76) in 2019, and 8\u00b76 (3\u00b76) in 2021. Only the differences in mean implementation score between 2014 and the other three report years were deemed statistically significant (pairwise p<0\u00b705). Thus the steady improvement in mean global NCD policy implementation stalled in 2021 at 47\u00b78%. However, from 2019 to 2021, we identified shifts in individual policies: global mean implementation scores increased for policies on tobacco, clinical guidelines, salt, and child food marketing, and decreased for policies on alcohol, breastmilk substitute marketing, physical activity mass media campaigns, risk factor surveys, and national NCD plans and targets. Six of the seven policies with the lowest levels of implementation (global mean score <0\u00b74 out of a potential 1\u00b70) in both 2019 and 2021 were related to tobacco, alcohol, and unhealthy food. From 2020 onwards, we identified weak or no associations between sales of tobacco, alcohol, and junk foods and the predicted probability of implementing policies related to each commodity. Country-level CFII was significantly associated with total policy implementation score (Pearson's r -0\u00b749, 95% CI -0\u00b759 to -0\u00b736), and this finding was supported in multivariate modelling for all policies combined and for all commercial policies except alcohol policies.\n\nNCD policy implementation has stagnated. Progress in the implementation of some policies is matched by decreased implementation of others, particularly those related to unhealthy commodities. To prevent NCDs and their consequences, and attain the Sustainable Development Goals, the rate of NCD policy adoption must be substantially and urgently increased before the next NCD progress monitor and UN high-level meeting on NCDs in 2024.\n\nNone.", "doi": "10.1016/S2214-109X(23)00042-6", "pmid": "36925173", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2214-109X(23)00042-6"}], "notes": [], "created": "2023-04-21T16:12:27.828Z", "modified": "2023-04-21T16:12:27.845Z"}, {"entity": "publication", "iuid": "c06838cf20b24f98b0b4adb60797e096", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c06838cf20b24f98b0b4adb60797e096.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c06838cf20b24f98b0b4adb60797e096"}}, "title": "Nirmatrelvir/ritonavir in COVID-19 patients with haematological malignancies: a report from the EPICOVIDEHA registry.", "authors": [{"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J"}, {"family": "Marchesi", "given": "Francesco", "initials": "F"}, {"family": "Gomes da Silva", "given": "Maria", "initials": "M"}, {"family": "Farina", "given": "Francesca", "initials": "F"}, {"family": "D\u00e1vila-Valls", "given": "Julio", "initials": "J"}, {"family": "Bilgin", "given": "Yavuz M", "initials": "YM"}, {"family": "Glenth\u00f8j", "given": "Andreas", "initials": "A"}, {"family": "Falces-Romero", "given": "Iker", "initials": "I"}, {"family": "Van Doesum", "given": "Jaap", "initials": "J"}, {"family": "Labrador", "given": "Jorge", "initials": "J"}, {"family": "Buquicchio", "given": "Caterina", "initials": "C"}, {"family": "El-Ashwah", "given": "Shaimaa", "initials": "S"}, {"family": "Petzer", "given": "Verena", "initials": "V"}, {"family": "Van Praet", "given": "Jens", "initials": "J"}, {"family": "Sch\u00f6nlein", "given": "Martin", "initials": "M"}, {"family": "Dargenio", "given": "Michelina", "initials": "M"}, {"family": "M\u00e9ndez", "given": "Gustavo-Adolfo", "initials": "GA"}, {"family": "Meers", "given": "Stef", "initials": "S"}, {"family": "Itri", "given": "Federico", "initials": "F"}, {"family": "Giordano", "given": "Antonio", "initials": "A"}, {"family": "Pincz\u00e9s", "given": "L\u00e1szl\u00f3 Imre", "initials": "LI"}, {"family": "Espigado", "given": "Ildefonso", "initials": "I"}, {"family": "Stojanoski", "given": "Zlate", "initials": "Z"}, {"family": "L\u00f3pez-Garc\u00eda", "given": "Alberto", "initials": "A"}, {"family": "Prezioso", "given": "Lucia", "initials": "L"}, {"family": "Jaksic", "given": "Ozren", "initials": "O"}, {"family": "Vena", "given": "Antonio", "initials": "A"}, {"family": "Fracchiolla", "given": "Nicola S", "initials": "NS"}, {"family": "Gonz\u00e1lez-L\u00f3pez", "given": "Tom\u00e1s Jos\u00e9", "initials": "TJ"}, {"family": "Colovi\u0107", "given": "Natasa", "initials": "N"}, {"family": "Delia", "given": "Mario", "initials": "M"}, {"family": "Weinbergerov\u00e1", "given": "Barbora", "initials": "B"}, {"family": "Marchetti", "given": "Monia", "initials": "M"}, {"family": "Marques de Almeida", "given": "Joyce", "initials": "J"}, {"family": "Finizio", "given": "Olimpia", "initials": "O"}, {"family": "Besson", "given": "Caroline", "initials": "C"}, {"family": "Biernat", "given": "Monika M", "initials": "MM"}, {"family": "Valkovi\u0107", "given": "Toni", "initials": "T"}, {"family": "Lahmer", "given": "Tobias", "initials": "T"}, {"family": "Cuccaro", "given": "Annarosa", "initials": "A"}, {"family": "Ormazabal-V\u00e9lez", "given": "Irati", "initials": "I"}, {"family": "Batini\u0107", "given": "Josip", "initials": "J"}, {"family": "Fern\u00e1ndez", "given": "Noem\u00ed", "initials": "N"}, {"family": "De Jonge", "given": "Nick", "initials": "N"}, {"family": "Tascini", "given": "Carlo", "initials": "C"}, {"family": "Anastasopoulou", "given": "Amalia N", "initials": "AN"}, {"family": "Dul\u00e9ry", "given": "R\u00e9my", "initials": "R"}, {"family": "Del Principe", "given": "Maria Ilaria", "initials": "MI"}, {"family": "Plantefeve", "given": "Ga\u00ebtan", "initials": "G"}, {"family": "Papa", "given": "Mario Virgilio", "initials": "MV"}, {"family": "Nucci", "given": "Marcio", "initials": "M"}, {"family": "Jim\u00e9nez", "given": "Moraima", "initials": "M"}, {"family": "Aujayeb", "given": "Avinash", "initials": "A"}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jos\u00e9-\u00c1ngel", "initials": "J\u00c1"}, {"family": "Merelli", "given": "Maria", "initials": "M"}, {"family": "Cattaneo", "given": "Chiara", "initials": "C"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Cabirta", "given": "Alba", "initials": "A"}, {"family": "Varricchio", "given": "Gina", "initials": "G"}, {"family": "Sacchi", "given": "Maria Vittoria", "initials": "MV"}, {"family": "Cordoba", "given": "Raul", "initials": "R"}, {"family": "Arellano", "given": "Elena", "initials": "E"}, {"family": "Gr\u00e4fe", "given": "Stefanie K", "initials": "SK"}, {"family": "Wolf", "given": "Dominik", "initials": "D"}, {"family": "Emarah", "given": "Ziad", "initials": "Z"}, {"family": "Ammatuna", "given": "Emanuele", "initials": "E"}, {"family": "Hersby", "given": "Ditte Stampe", "initials": "DS"}, {"family": "Mart\u00edn-P\u00e9rez", "given": "Sonia", "initials": "S"}, {"family": "Nunes Rodrigues", "given": "Raquel", "initials": "R"}, {"family": "Rahimli", "given": "Laman", "initials": "L"}, {"family": "Pagano", "given": "Livio", "initials": "L"}, {"family": "Cornely", "given": "Oliver A", "initials": "OA"}, {"family": "EPICOVIDEHA registry", "given": "", "initials": ""}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": "58", "pages": "101939", "issn-l": null}, "abstract": "Nirmatrelvir/ritonavir treatment decreases the hospitalisation rate in immunocompetent patients with COVID-19, but data on efficacy in patients with haematological malignancy are scarce. Here, we describe the outcome of nirmatrelvir/ritonavir treatment in a large cohort of the latter patients.\n\nThis is a retrospective cohort study from the multicentre EPICOVIDEHA registry (NCT04733729) on patients with haematological malignancy, who were diagnosed with COVID-19 between January and September 2022. Patients receiving nirmatrelvir/ritonavir were compared to those who did not. A logistic regression was run to determine factors associated with nirmatrelvir/ritonavir administration in our sample. Mortality between treatment groups was assessed with Kaplan-Meier survival plots after matching all the patients with a propensity score. Additionally, a Cox regression was modelled to detect factors associated with mortality in patients receiving nirmatrelvir/ritonavir.\n\nA total of 1859 patients were analysed, 117 (6%) were treated with nirmatrelvir/ritonavir, 1742 (94%) were treated otherwise. Of 117 patients receiving nirmatrelvir/ritonavir, 80% had received \u22651 anti-SARS-CoV-2 vaccine dose before COVID-19 onset, 13% of which received a 2nd vaccine booster. 5% were admitted to ICU. Nirmatrelvir/ritonavir treatment was associated with the presence of extrapulmonary symptoms at COVID-19 onset, for example anosmia, fever, rhinitis, or sinusitis (aOR 2.509, 95%CI 1.448-4.347) and 2nd vaccine booster (aOR 3.624, 95%CI 1.619-8.109). Chronic pulmonary disease (aOR 0.261, 95%CI 0.093-0.732) and obesity (aOR 0.105, 95%CI 0.014-0.776) were not associated with nirmatrelvir/ritonavir use. After propensity score matching, day-30 mortality rate in patients treated with nirmatrelvir/ritonavir was 2%, significantly lower than in patients with SARS-CoV-2 directed treatment other than nirmatrelvir/ritonavir (11%, p = 0.036). No factor was observed explaining the mortality difference in patients after nirmatrelvir/ritonavir administration.\n\nHaematological malignancy patients were more likely to receive nirmatrelvir/ritonavir when reporting extrapulmonary symptoms or 2nd vaccine booster at COVID-19 onset, as opposed to chronic pulmonary disease and obesity. The mortality rate in patients treated with nirmatrelvir/ritonavir was lower than in patients with targeted drugs other than nirmatrelvir/ritonavir.\n\nEPICOVIDEHA has received funds from Optics COMMIT (COVID-19 Unmet Medical Needs and Associated Research Extension) COVID-19 RFP program by GILEAD Science, United States (Project 2020-8223).", "doi": "10.1016/j.eclinm.2023.101939", "pmid": "37041967", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC10078172"}, {"db": "pii", "key": "S2589-5370(23)00116-5"}], "notes": [], "created": "2023-04-20T17:27:35.535Z", "modified": "2023-04-20T17:27:35.548Z"}, {"entity": "publication", "iuid": "ddb832068b7446a09e1cbe96bdfe296d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ddb832068b7446a09e1cbe96bdfe296d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ddb832068b7446a09e1cbe96bdfe296d"}}, "title": "New perspectives on respiratory syncytial virus surveillance at the national level: lessons from the COVID-19 pandemic.", "authors": [{"family": "Teirlinck", "given": "Anne C", "initials": "AC", "orcid": "0000-0002-1172-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e135044218dd473e93ce8aa1af84bfde.json"}}, {"family": "Johannesen", "given": "Caroline K", "initials": "CK"}, {"family": "Broberg", "given": "Eeva K", "initials": "EK"}, {"family": "Penttinen", "given": "Pasi", "initials": "P", "orcid": "0000-0001-6929-1086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b71cf06d6ef4127b7816b76ab9b7bf0.json"}}, {"family": "Campbell", "given": "Harry", "initials": "H"}, {"family": "Nair", "given": "Harish", "initials": "H"}, {"family": "Reeves", "given": "Rachel M", "initials": "RM", "orcid": "0000-0002-8949-1568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8dd33b5dce254580806961ea8168490a.json"}}, {"family": "B\u00f8\u00e5s", "given": "H\u00e5kon", "initials": "H", "orcid": "0000-0002-5917-1563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9cc00f104cd64e53ab58eebd46368861.json"}}, {"family": "Brytting", "given": "Mia", "initials": "M"}, {"family": "Cai", "given": "Wei", "initials": "W"}, {"family": "Carnahan", "given": "AnnaSara", "initials": "A"}, {"family": "Casalegno", "given": "Jean-Sebastien", "initials": "JS"}, {"family": "Danis", "given": "Kostas", "initials": "K", "orcid": "0000-0001-6727-7344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19a6a9cd4dc74ca19c47878e93daa5ef.json"}}, {"family": "De Gascun", "given": "Cillian", "initials": "C"}, {"family": "Ellis", "given": "Joanna", "initials": "J"}, {"family": "Emborg", "given": "Hanne-Dorthe", "initials": "HD"}, {"family": "Gijon", "given": "Manuel", "initials": "M"}, {"family": "Guiomar", "given": "Raquel", "initials": "R"}, {"family": "Hirve", "given": "Siddhivinayak S", "initials": "SS"}, {"family": "Ji\u0159incov\u00e1", "given": "Helena", "initials": "H"}, {"family": "Nohynek", "given": "Hanna", "initials": "H"}, {"family": "Oliva", "given": "Jesus Angel", "initials": "JA", "orcid": "0000-0003-4080-7864", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6aab0b9fa36a4c88ac2e9714d3adacdf.json"}}, {"family": "Osei-Yeboah", "given": "Richard", "initials": "R", "orcid": "0000-0003-4622-3691", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14dca19cd0d84d8299341d3eb1357608.json"}}, {"family": "Paget", "given": "John", "initials": "J"}, {"family": "Pakarna", "given": "Gatis", "initials": "G"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "Presser", "given": "Lance", "initials": "L"}, {"family": "Rapp", "given": "Marie", "initials": "M"}, {"family": "Reiche", "given": "Janine", "initials": "J"}, {"family": "Rodrigues", "given": "Ana Paula", "initials": "AP"}, {"family": "Sepp\u00e4l\u00e4", "given": "Elina", "initials": "E"}, {"family": "Socan", "given": "Maja", "initials": "M"}, {"family": "Szymanski", "given": "Karol", "initials": "K", "orcid": "0000-0003-3269-0774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0811c53f65a34c4285dc00e449c16033.json"}}, {"family": "Trebbien", "given": "Ramona", "initials": "R"}, {"family": "Ve\u010de\u0159ov\u00e1", "given": "Jarom\u00edra", "initials": "J"}, {"family": "van der Werf", "given": "Sylvie", "initials": "S", "orcid": "0000-0002-1148-4456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/610e999fc3fa4d24aceecf5a13122ecf.json"}}, {"family": "Zambon", "given": "Maria", "initials": "M"}, {"family": "Meijer", "given": "Adam", "initials": "A", "orcid": "0000-0001-8074-7582", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa6d8f61c7ca4618a4b00d12144bac2d.json"}}, {"family": "Fischer", "given": "Thea K", "initials": "TK"}], "type": "editorial", "published": "2023-04-00", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "volume": "61", "issue": "4", "issn-l": "0903-1936"}, "abstract": "Learning from the COVID-19 pandemic and considering the effects of this pandemic, we provide recommendations that can guide towards sustainable RSV surveillance with the potential to be integrated into the broader perspective of respiratory surveillance. https://bit.ly/40TsO0G", "doi": "10.1183/13993003.01569-2022", "pmid": "37012081", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10069872"}, {"db": "pii", "key": "61/4/2201569"}], "notes": [], "created": "2023-04-20T17:35:20.998Z", "modified": "2023-04-20T17:39:19.993Z"}, {"entity": "publication", "iuid": "6fba8541d13c406298fc41acd760220c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6fba8541d13c406298fc41acd760220c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6fba8541d13c406298fc41acd760220c"}}, "title": "Emergence and antibody evasion of BQ, BA.2.75 and SARS-CoV-2 recombinant sub-lineages in the face of maturing antibody breadth at the population level.", "authors": [{"family": "Akerman", "given": "Anouschka", "initials": "A"}, {"family": "Milogiannakis", "given": "Vanessa", "initials": "V"}, {"family": "Jean", "given": "Tyra", "initials": "T"}, {"family": "Esneau", "given": "Camille", "initials": "C"}, {"family": "Silva", "given": "Mariana Ruiz", "initials": "MR"}, {"family": "Ison", "given": "Timothy", "initials": "T"}, {"family": "Fichter", "given": "Christina", "initials": "C"}, {"family": "Lopez", "given": "Joseph A", "initials": "JA"}, {"family": "Chandra", "given": "Deborah", "initials": "D"}, {"family": "Naing", "given": "Zin", "initials": "Z"}, {"family": "Caguicla", "given": "Joanna", "initials": "J"}, {"family": "Li", "given": "Daiyang", "initials": "D"}, {"family": "Walker", "given": "Gregory", "initials": "G"}, {"family": "Amatayakul-Chantler", "given": "Supavadee", "initials": "S"}, {"family": "Roth", "given": "Nathan", "initials": "N"}, {"family": "Manni", "given": "Sandro", "initials": "S"}, {"family": "Hauser", "given": "Thomas", "initials": "T"}, {"family": "Barnes", "given": "Thomas", "initials": "T"}, {"family": "Condylios", "given": "Anna", "initials": "A"}, {"family": "Yeang", "given": "Malinna", "initials": "M"}, {"family": "Wong", "given": "Maureen", "initials": "M"}, {"family": "Foster", "given": "Charles S P", "initials": "CSP"}, {"family": "Sato", "given": "Kenta", "initials": "K"}, {"family": "Lee", "given": "Sharon", "initials": "S"}, {"family": "Song", "given": "Yang", "initials": "Y"}, {"family": "Mao", "given": "Lijun", "initials": "L"}, {"family": "Sigmund", "given": "Allison", "initials": "A"}, {"family": "Phu", "given": "Amy", "initials": "A"}, {"family": "Vande More", "given": "Ann Marie", "initials": "AM"}, {"family": "Hunt", "given": "Stephanie", "initials": "S"}, {"family": "Douglas", "given": "Mark", "initials": "M"}, {"family": "Caterson", "given": "Ian", "initials": "I"}, {"family": "Britton", "given": "Warwick", "initials": "W"}, {"family": "Sandgren", "given": "Kerrie", "initials": "K"}, {"family": "Bull", "given": "Rowena", "initials": "R"}, {"family": "Lloyd", "given": "Andrew", "initials": "A"}, {"family": "Triccas", "given": "Jamie", "initials": "J"}, {"family": "Tangye", "given": "Stuart", "initials": "S"}, {"family": "Bartlett", "given": "Nathan W", "initials": "NW"}, {"family": "Darley", "given": "David", "initials": "D"}, {"family": "Matthews", "given": "Gail", "initials": "G"}, {"family": "Stark", "given": "Damien J", "initials": "DJ"}, {"family": "Petoumenos", "given": "Kathy", "initials": "K"}, {"family": "Rawlinson", "given": "William D", "initials": "WD"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Brilot", "given": "Fabienne", "initials": "F"}, {"family": "Cunningham", "given": "Anthony L", "initials": "AL"}, {"family": "Kelleher", "given": "Anthony D", "initials": "AD"}, {"family": "Aggarwal", "given": "Anupriya", "initials": "A"}, {"family": "Turville", "given": "Stuart G", "initials": "SG"}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "volume": "90", "pages": "104545", "issn-l": null}, "abstract": "The Omicron era of the COVID-19 pandemic commenced at the beginning of 2022 and whilst it started with primarily BA.1, it was latter dominated by BA.2 and the related sub-lineage BA.5. Following resolution of the global BA.5 wave, a diverse grouping of Omicron sub-lineages emerged derived from BA.2, BA.5 and recombinants thereof. Whilst emerging from distinct lineages, all shared similar changes in the Spike glycoprotein affording them an outgrowth advantage through evasion of neutralising antibodies.\n\nOver the course of 2022, we monitored the potency and breadth of antibody neutralization responses to many emerging variants in the Australian community at three levels: (i) we tracked over 420,000 U.S. plasma donors over time through various vaccine booster roll outs and Omicron waves using sequentially collected IgG pools; (ii) we mapped the antibody response in individuals using blood from stringently curated vaccine and convalescent cohorts. (iii) finally we determine the in vitro efficacy of clinically approved therapies Evusheld and Sotrovimab.\n\nIn pooled IgG samples, we observed the maturation of neutralization breadth to Omicron variants over time through continuing vaccine and infection waves. Importantly, in many cases, we observed increased antibody breadth to variants that were yet to be in circulation. Determination of viral neutralization at the cohort level supported equivalent coverage across prior and emerging variants with isolates BQ.1.1, XBB.1, BR.2.1 and XBF the most evasive. Further, these emerging variants were resistant to Evusheld, whilst increasing neutralization resistance to Sotrovimab was restricted to BQ.1.1 and XBF. We conclude at this current point in time that dominant variants can evade antibodies at levels equivalent to their most evasive lineage counterparts but sustain an entry phenotype that continues to promote an additional outgrowth advantage. In Australia, BR.2.1 and XBF share this phenotype and, in contrast to global variants, are uniquely dominant in this region in the later months of 2022.\n\nWhilst the appearance of a diverse range of omicron lineages has led to primary or partial resistance to clinically approved monoclonal antibodies, the maturation of the antibody response across both cohorts and a large donor pools importantly observes increasing breadth in the antibody neutralisation responses over time with a trajectory that covers both current and known emerging variants.\n\nThis work was primarily supported by Australian Medical Foundation research grants MRF2005760 (SGT, GM & WDR), Medical Research Future Fund Antiviral Development Call grant (WDR), the New South Wales Health COVID-19 Research Grants Round 2 (SGT & FB) and the NSW Vaccine Infection and Immunology Collaborative (VIIM) (ALC). Variant modeling was supported by funding from SciLifeLab's Pandemic Laboratory Preparedness program to B.M. (VC-2022-0028) and by the European Union's Horizon 2020 research and innovation programme under grant agreement no. 101003653 (CoroNAb) to B.M.", "doi": "10.1016/j.ebiom.2023.104545", "pmid": "37002990", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10060887"}, {"db": "pii", "key": "S2352-3964(23)00110-X"}], "notes": [], "created": "2023-04-20T17:41:13.979Z", "modified": "2023-04-20T17:41:13.982Z"}, {"entity": "publication", "iuid": "04186ca4c37344d585b7d735b4454a72", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/04186ca4c37344d585b7d735b4454a72.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/04186ca4c37344d585b7d735b4454a72"}}, "title": "Contextualising adverse events of special interest to characterise the baseline incidence rates in 24 million patients with COVID-19 across 26 databases: a multinational retrospective cohort study.", "authors": [{"family": "Voss", "given": "Erica A", "initials": "EA"}, {"family": "Shoaibi", "given": "Azza", "initials": "A"}, {"family": "Yin Hui Lai", "given": "Lana", "initials": "L"}, {"family": "Blacketer", "given": "Clair", "initials": "C"}, {"family": "Alshammari", "given": "Thamir", "initials": "T"}, {"family": "Makadia", "given": "Rupa", "initials": "R"}, {"family": "Haynes", "given": "Kevin", "initials": "K"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Rao", "given": "Gowtham", "initials": "G"}, {"family": "van Sandijk", "given": "Sebastiaan", "initials": "S"}, {"family": "Fraboulet", "given": "Clement", "initials": "C"}, {"family": "Boyer", "given": "Laurent", "initials": "L"}, {"family": "Le Carrour", "given": "Tanguy", "initials": "T"}, {"family": "Horban", "given": "Scott", "initials": "S"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Mart\u00ednez Rold\u00e1n", "given": "Jordi", "initials": "J"}, {"family": "Ram\u00edrez-Anguita", "given": "Juan Manuel", "initials": "JM"}, {"family": "Mayer", "given": "Miguel A", "initials": "MA"}, {"family": "de Wilde", "given": "Marcel", "initials": "M"}, {"family": "John", "given": "Luis H", "initials": "LH"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "Roel", "given": "Elena", "initials": "E"}, {"family": "Pistillo", "given": "Andrea", "initials": "A"}, {"family": "Kolde", "given": "Raivo", "initials": "R"}, {"family": "Maljkovi\u0107", "given": "Filip", "initials": "F"}, {"family": "Denaxas", "given": "Spiros", "initials": "S"}, {"family": "Papez", "given": "Vaclav", "initials": "V"}, {"family": "Kahn", "given": "Michael G", "initials": "MG"}, {"family": "Natarajan", "given": "Karthik", "initials": "K"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Secora", "given": "Alex", "initials": "A"}, {"family": "Minty", "given": "Evan P", "initials": "EP"}, {"family": "Shah", "given": "Nigam H", "initials": "NH"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Garcia Morales", "given": "Maria Teresa", "initials": "MT"}, {"family": "Bosca", "given": "Diego", "initials": "D"}, {"family": "Cadenas Juanino", "given": "Honorio", "initials": "H"}, {"family": "Diaz Holgado", "given": "Antonio", "initials": "A"}, {"family": "Pedrera Jim\u00e9nez", "given": "Miguel", "initials": "M"}, {"family": "Serrano Balazote", "given": "Pablo", "initials": "P"}, {"family": "Garc\u00eda Barrio", "given": "Noelia", "initials": "N"}, {"family": "\u015een", "given": "Sel\u00e7uk", "initials": "S"}, {"family": "\u00dcresin", "given": "Ali Ya\u011f\u0131z", "initials": "AY"}, {"family": "Erdogan", "given": "Baris", "initials": "B"}, {"family": "Belmans", "given": "Luc", "initials": "L"}, {"family": "Byttebier", "given": "Geert", "initials": "G"}, {"family": "Malbrain", "given": "Manu L N G", "initials": "MLNG"}, {"family": "Dedman", "given": "Daniel J", "initials": "DJ"}, {"family": "Cuccu", "given": "Zara", "initials": "Z"}, {"family": "Vashisht", "given": "Rohit", "initials": "R"}, {"family": "Butte", "given": "Atul J", "initials": "AJ"}, {"family": "Patel", "given": "Ayan", "initials": "A"}, {"family": "Dahm", "given": "Lisa", "initials": "L"}, {"family": "Han", "given": "Cora", "initials": "C"}, {"family": "Bu", "given": "Fan", "initials": "F"}, {"family": "Arshad", "given": "Faaizah", "initials": "F"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Prieto-Alhambra", "given": "Dani", "initials": "D"}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR"}, {"family": "Schuemie", "given": "Martijn J", "initials": "MJ"}, {"family": "Ryan", "given": "Patrick B", "initials": "PB"}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": "58", "pages": "101932", "issn-l": null}, "abstract": "Adverse events of special interest (AESIs) were pre-specified to be monitored for the COVID-19 vaccines. Some AESIs are not only associated with the vaccines, but with COVID-19. Our aim was to characterise the incidence rates of AESIs following SARS-CoV-2 infection in patients and compare these to historical rates in the general population.\n\nA multi-national cohort study with data from primary care, electronic health records, and insurance claims mapped to a common data model. This study's evidence was collected between Jan 1, 2017 and the conclusion of each database (which ranged from Jul 2020 to May 2022). The 16 pre-specified prevalent AESIs were: acute myocardial infarction, anaphylaxis, appendicitis, Bell's palsy, deep vein thrombosis, disseminated intravascular coagulation, encephalomyelitis, Guillain- Barr\u00e9 syndrome, haemorrhagic stroke, non-haemorrhagic stroke, immune thrombocytopenia, myocarditis/pericarditis, narcolepsy, pulmonary embolism, transverse myelitis, and thrombosis with thrombocytopenia. Age-sex standardised incidence rate ratios (SIR) were estimated to compare post-COVID-19 to pre-pandemic rates in each of the databases.\n\nSubstantial heterogeneity by age was seen for AESI rates, with some clearly increasing with age but others following the opposite trend. Similarly, differences were also observed across databases for same health outcome and age-sex strata. All studied AESIs appeared consistently more common in the post-COVID-19 compared to the historical cohorts, with related meta-analytic SIRs ranging from 1.32 (1.05 to 1.66) for narcolepsy to 11.70 (10.10 to 13.70) for pulmonary embolism.\n\nOur findings suggest all AESIs are more common after COVID-19 than in the general population. Thromboembolic events were particularly common, and over 10-fold more so. More research is needed to contextualise post-COVID-19 complications in the longer term.\n\nNone.", "doi": "10.1016/j.eclinm.2023.101932", "pmid": "37034358", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10072853"}, {"db": "pii", "key": "S2589-5370(23)00109-8"}], "notes": [], "created": "2023-04-20T17:29:48.848Z", "modified": "2023-04-20T17:29:48.862Z"}, {"entity": "publication", "iuid": "02795f7098f24bff96850deb84f65aac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02795f7098f24bff96850deb84f65aac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02795f7098f24bff96850deb84f65aac"}}, "title": "Changes in sexual activities, function, and satisfaction during the COVID-19 pandemic era: a systematic review and meta-analysis.", "authors": [{"family": "Qaderi", "given": "Kowsar", "initials": "K"}, {"family": "Yazdkhasti", "given": "Mansoureh", "initials": "M"}, {"family": "Zangeneh", "given": "Sanaz", "initials": "S"}, {"family": "Behbahani", "given": "Bahar Morshed", "initials": "BM"}, {"family": "Kalhor", "given": "Mehri", "initials": "M"}, {"family": "Shamsabadi", "given": "Ahmadreza", "initials": "A"}, {"family": "Jesmani", "given": "Younes", "initials": "Y"}, {"family": "Norouzi", "given": "Solmaz", "initials": "S"}, {"family": "Kajbafvala", "given": "Mehrnaz", "initials": "M"}, {"family": "Khodavirdilou", "given": "Rasa", "initials": "R"}, {"family": "Rahmani", "given": "Nahid", "initials": "N"}, {"family": "Namadian", "given": "Masoumeh", "initials": "M"}, {"family": "Ezabadi", "given": "Sajjad Ghane", "initials": "SG"}, {"family": "Alkatout", "given": "Ibrahim", "initials": "I"}, {"family": "Mehraeen", "given": "Esmaeel", "initials": "E"}, {"family": "Rasoal", "given": "Dara", "initials": "D"}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "Sex Med", "issn": "2050-1161", "volume": "11", "issue": "2", "pages": "qfad005", "issn-l": null}, "abstract": "Little is known about the impact of the coronavirus on sexual behavior, function, and satisfaction.\n\nThe aim of the present study was to systematically review people's sexual function and behaviors and their changes in sexual activities during the COVID-19 pandemic.\n\nComprehensive searches in PubMed, Web of Science, and Scopus were conducted with keywords in accordance with MeSH terms: COVID-19, SARS-CoV-2, coronavirus, sexual health, sexual function, sexual dysfunctions, sexuality, sexual orientation, sexual activities, and premarital sex. Two reviewers independently assessed full-text articles according to predefined criteria: original design, English studies, and investigating either the general population or sexual minorities.\n\nRisk of bias in the studies was assessed by the Newcastle-Ottawa Scale, and data were pooled via random effects meta-analyses. We utilized the standardized mean difference to evaluate the effects of the COVID-19 pandemic on sexual activity, functioning, and satisfaction. We included 19 studies in the analysis and 11 studies in the meta-analysis, with a sample size of 12 350. To investigate sexual activity changes, a sample size of 8838 was entered into the subgroup analysis, which showed a significant decrease in both genders (5821 women, P < .033; 3017 men, P < .008). A subgroup meta-analysis showed that the sexual function of men and women during the COVID-19 pandemic significantly declined (3974 women, P < .001; 1427 men, P < .001). Sexual desire and arousal decreased in both genders, though mainly in women. In investigating sexual satisfaction changes during the COVID-19 pandemic, a meta-analysis with a sample size of 2711 showed a significant decrease (P < .001). The most indicative changes in sexual behaviors during the pandemic were the increase in masturbating and usage of sex toys. Greater COVID-19 knowledge was associated with lower masturbation, oral sex, and vaginal sex. The more protective behaviors were associated with less hugging, kissing, cuddling, genital touching, watching porn with a partner, and vaginal sex.\n\nThe COVID-19 pandemic led to increased challenges and changes for individuals' sexual behaviors. Efforts for preventive strategies should therefore be concentrated between pandemics, while ensuring that there is information available to the population during a pandemic for help in times of psychological distress or crisis.", "doi": "10.1093/sexmed/qfad005", "pmid": "36970584", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10037164"}, {"db": "pii", "key": "qfad005"}], "notes": [], "created": "2023-04-21T16:00:18.555Z", "modified": "2023-04-21T16:00:42.709Z"}, {"entity": "publication", "iuid": "9187c61acefa4eae9abaaebe2dbac652", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9187c61acefa4eae9abaaebe2dbac652.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9187c61acefa4eae9abaaebe2dbac652"}}, "title": "An XAI approach for COVID-19 detection using transfer learning with X-ray images.", "authors": [{"family": "Sarp", "given": "Salih", "initials": "S"}, {"family": "Catak", "given": "Ferhat Ozgur", "initials": "FO"}, {"family": "Kuzlu", "given": "Murat", "initials": "M"}, {"family": "Cali", "given": "Umit", "initials": "U"}, {"family": "Kusetogullari", "given": "Huseyin", "initials": "H"}, {"family": "Zhao", "given": "Yanxiao", "initials": "Y"}, {"family": "Ates", "given": "Gungor", "initials": "G"}, {"family": "Guler", "given": "Ozgur", "initials": "O"}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": "9", "issue": "4", "pages": "e15137", "issn-l": null}, "abstract": "The coronavirus disease (COVID-19) has continued to cause severe challenges during this unprecedented time, affecting every part of daily life in terms of health, economics, and social development. There is an increasing demand for chest X-ray (CXR) scans, as pneumonia is the primary and vital complication of COVID-19. CXR is widely used as a screening tool for lung-related diseases due to its simple and relatively inexpensive application. However, these scans require expert radiologists to interpret the results for clinical decisions, i.e., diagnosis, treatment, and prognosis. The digitalization of various sectors, including healthcare, has accelerated during the pandemic, with the use and importance of Artificial Intelligence (AI) dramatically increasing. This paper proposes a model using an Explainable Artificial Intelligence (XAI) technique to detect and interpret COVID-19 positive CXR images. We further analyze the impact of COVID-19 positive CXR images using heatmaps. The proposed model leverages transfer learning and data augmentation techniques for faster and more adequate model training. Lung segmentation is applied to enhance the model performance further. We conducted a pre-trained network comparison with the highest classification performance (F1-Score: 98%) using the ResNet model.", "doi": "10.1016/j.heliyon.2023.e15137", "pmid": "37041935", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10080863"}, {"db": "pii", "key": "S2405-8440(23)02344-7"}], "notes": [], "created": "2023-04-20T17:27:55.201Z", "modified": "2023-04-20T17:28:06.103Z"}, {"entity": "publication", "iuid": "69c29e2854784570bf943d9f060510a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69c29e2854784570bf943d9f060510a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69c29e2854784570bf943d9f060510a6"}}, "title": "Systemic sclerosis and COVID-19 vaccine safety: short-term insights from the global COVID-19 vaccination in autoimmune disease (COVAD) survey.", "authors": [{"family": "Naveen", "given": "R", "initials": "R", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Thakare", "given": "Darpan R", "initials": "DR", "orcid": "0000-0002-6852-4869", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b89611ef037490fb80a852b74f67752.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Pauling", "given": "John D", "initials": "JD", "orcid": "0000-0002-2793-2364", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e37709273d404d17a88c7c850777b99f.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Jagtap", "given": "Kshitij", "initials": "K", "orcid": "0000-0003-2729-737X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822b9da98e5d4eb2975ff97fe484933f.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Saha", "given": "Sreoshy", "initials": "S", "orcid": "0000-0001-6745-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00238845dd4833ae51ffb75e2fe144.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Kardes", "given": "Sinan", "initials": "S", "orcid": "0000-0002-6311-8634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2900c3ca00da476a8914574384a3c9c2.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "COVAD Study Group", "given": "", "initials": ""}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}], "type": "journal article", "published": "2023-03-31", "journal": {"title": "Rheumatol Int", "issn": "1437-160X", "pages": "1-11", "issn-l": null}, "abstract": "The safety profile of COVID-19 vaccines is understudied in patients with systemic sclerosis (SSc). We compared short-term adverse events (AEs) 7 days following vaccination in patients with SSc vs other rheumatic (AIRDs), non-rheumatic autoimmune diseases (nrAIDs), and healthy controls (HCs). The COVID-19 Vaccination in autoimmune diseases (COVAD) self-reporting e-survey was circulated by a group of > 110 collaborators in 94 countries from March to December 2021. AEs were analyzed between different groups using regression models. Of 10,679 complete respondents [73.8% females, mean age 43 years, 53% Caucasians], 478 had SSc. 83% had completed two vaccine doses, Pfizer-BioNTech (BNT162b2) (51%) was the most common. Minor and major AEs were reported by 81.2% and 3.3% SSc patients, respectively, and did not differ significantly with disease activity or different vaccine types, though with minor symptom differences. Frequencies of AEs were not affected by background immunosuppression, though SSc patients receiving hydroxychloroquine experienced fatigue less commonly (OR 0.4; 95% CI 0.2-0.8). Frequency of AEs and hospitalisations were similar to other AIRDs, nrAIDs, and HC except a higher risk of chills (OR 1.3; 95% CI 1.0-1.7) and fatigue (OR 1.3; 95% CI 1.0-1.6) compared to other AIRDs. COVID-19 vaccines were largely safe and well tolerated in SSc patients in the short term. Background immunosuppression and disease activity did not influence the vaccination-related short-term AEs.", "doi": "10.1007/s00296-023-05310-9", "pmid": "37000295", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10064600"}, {"db": "pii", "key": "10.1007/s00296-023-05310-9"}], "notes": [], "created": "2023-04-20T17:42:14.492Z", "modified": "2023-04-20T17:42:21.934Z"}, {"entity": "publication", "iuid": "8a7a4dc6524c476fbdf4224540d925f6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a7a4dc6524c476fbdf4224540d925f6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a7a4dc6524c476fbdf4224540d925f6"}}, "title": "Ionizable lipids penetrate phospholipid bilayers with high phase transition temperatures: perspectives from free energy calculations.", "authors": [{"family": "Ermilova", "given": "Inna", "initials": "I"}, {"family": "Swenson", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2023-03-31", "journal": {"title": "Chem Phys Lipids", "issn": "1873-2941", "volume": "253", "pages": "105294", "issn-l": null}, "abstract": "The efficacies of modern gene-therapies strongly depend on their contents. At the same time the most potent formulations might not contain the best compounds. In this work we investigated the effect of phospholipids and their saturation on the binding ability of (6Z,9Z,28Z,31Z)-heptatriacont-6,9,28,31-tetraene-19-yl 4-(dimethylamino) butanoate (DLin-MC3-DMA) to model membranes at the neutral pH. We discovered that DLin-MC3-DMA has affinity to the most saturated monocomponent lipid bilayer 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and an aversion to the unsaturated one 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC). The preference to a certain membrane was also well-correlated to the phase transition temperatures of phospholipid bilayers, and to their structural and dynamical properties. Additionally, in the case of the presence of DLin-MC3-DMA in the membrane with DOPC the ionizable lipid penetrated it, which indicates possible synergistic effects. Comparisons with other ionizable lipids were performed using a model lipid bilayer of 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine (POPC). Particularly, the lipids heptadecan-9-yl 8-[2-hydroxyethyl-(6-oxo-6-undecoxyhexyl)amino]octanoate (SM-102) and [(4-hydroxybutyl) azanediyl] di(hexane-6,1-diyl) bis(2-hexyldecanoate) (ALC-0315) from modern mRNA-vaccines against COVID-19 were investigated and force fields parameters were derived for those new lipids. It was discovered that ALC-0315 binds strongest to the membrane, while DLin-MC3-DMA is not able to reside in the bilayer center. The ability to penetrate the membrane POPC by SM-102 and ALC-0315 can be related to their saturation, comparing to DLin-MC3-DMA.", "doi": "10.1016/j.chemphyslip.2023.105294", "pmid": "37003484", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0009-3084(23)00016-6"}], "notes": [], "created": "2023-04-20T17:40:26.665Z", "modified": "2023-04-20T17:40:26.698Z"}, {"entity": "publication", "iuid": "f937469419534ab381cfbf50a42f32f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f937469419534ab381cfbf50a42f32f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f937469419534ab381cfbf50a42f32f7"}}, "title": "Addressing global disparities in blood pressure control: perspectives of the International Society of Hypertension.", "authors": [{"family": "Schutte", "given": "Aletta E", "initials": "AE", "orcid": "0000-0001-9217-4937", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/101d8070a2cb43b198f974d3c40eaa4c.json"}}, {"family": "Jafar", "given": "Tazeen H", "initials": "TH", "orcid": "0000-0001-7454-8376", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96c13f8991f54072b38dcf21358e886b.json"}}, {"family": "Poulter", "given": "Neil R", "initials": "NR", "orcid": "0000-0002-6292-997X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4533dad3e82f4033bd1759f6792d60ee.json"}}, {"family": "Damasceno", "given": "Albertino", "initials": "A", "orcid": "0000-0002-5547-0224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2545cf0bbaf46629c6a5b0df1e0a887.json"}}, {"family": "Khan", "given": "Nadia A", "initials": "NA"}, {"family": "Nilsson", "given": "Peter M", "initials": "PM", "orcid": "0000-0002-5652-8459", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24f3c955840443a2a7b61839834ca30c.json"}}, {"family": "Alsaid", "given": "Jafar", "initials": "J", "orcid": "0000-0002-0269-5630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8033a5b1ce92459ea5aac83edc94b770.json"}}, {"family": "Neupane", "given": "Dinesh", "initials": "D", "orcid": "0000-0002-1501-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cdf496b02ca4c75ae012d8b88fd2513.json"}}, {"family": "Kario", "given": "Kazuomi", "initials": "K", "orcid": "0000-0002-8251-4480", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fc9431ed85a4f28a68540e3119e63b9.json"}}, {"family": "Beheiry", "given": "Hind", "initials": "H", "orcid": "0000-0001-6905-1867", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc79ed8474c84e24b20f492877aff5d7.json"}}, {"family": "Brouwers", "given": "Sofie", "initials": "S", "orcid": "0000-0002-7081-4881", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06fb9e105ad242489f5e7d8dda926b6b.json"}}, {"family": "Burger", "given": "Dylan", "initials": "D", "orcid": "0000-0003-3951-2911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6998a09484264b42b22222219cd3dc3c.json"}}, {"family": "Charchar", "given": "Fadi J", "initials": "FJ", "orcid": "0000-0002-6164-9941", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db655f3c3bfa4a95837434be78187209.json"}}, {"family": "Cho", "given": "Myeong-Chan", "initials": "MC", "orcid": "0000-0002-0047-0227", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98ded8bfd8194c809224851131643c43.json"}}, {"family": "Guzik", "given": "Tomasz J", "initials": "TJ", "orcid": "0000-0002-5039-7849", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72f67c1d004e45d294553c8a9dec0545.json"}}, {"family": "Haji Al-Saedi", "given": "Ghazi F", "initials": "GF", "orcid": "0000-0001-5261-3106", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c2adbf00e8f4a178adb1458e3cb30bc.json"}}, {"family": "Ishaq", "given": "Muhammad", "initials": "M", "orcid": "0000-0001-9725-2164", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fadfe352b564e738c49ada92afa5700.json"}}, {"family": "Itoh", "given": "Hiroshi", "initials": "H", "orcid": "0000-0003-2514-4919", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb8fd0d9f90549a182897d73f1cb4216.json"}}, {"family": "Jones", "given": "Erika S W", "initials": "ESW", "orcid": "0000-0002-3569-3498", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62c0de53e979472aaad042d112643338.json"}}, {"family": "Khan", "given": "Taskeen", "initials": "T", "orcid": "0000-0002-1676-4895", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/829167b193864e118e478dca9414f7a8.json"}}, {"family": "Kokubo", "given": "Yoshihiro", "initials": "Y", "orcid": "0000-0002-0705-9449", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79bbc719d1a44d5db033585b9fc784e8.json"}}, {"family": "Kotruchin", "given": "Praew", "initials": "P", "orcid": "0000-0003-3519-3415", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fcfb1decd3bd451eb143bbf48db8eb64.json"}}, {"family": "Muxfeldt", "given": "Elizabeth", "initials": "E", "orcid": "0000-0003-3853-7842", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8338f3cb9cab414fbd89828994fe210c.json"}}, {"family": "Odili", "given": "Augustine", "initials": "A", "orcid": "0000-0002-4564-1587", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dff5dcd1a2604323805b91f403b8a038.json"}}, {"family": "Patil", "given": "Mansi", "initials": "M", "orcid": "0000-0002-2337-385X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03056f2f9f4544fd9f1e5f5570e6f262.json"}}, {"family": "Ralapanawa", "given": "Udaya", "initials": "U", "orcid": "0000-0002-7416-7984", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c87c01d2e0294e7dbbad6f39666e34c5.json"}}, {"family": "Romero", "given": "Cesar A", "initials": "CA", "orcid": "0000-0002-8445-9665", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/391ecd75a1b14398989524d9c016b738.json"}}, {"family": "Schlaich", "given": "Markus P", "initials": "MP", "orcid": "0000-0002-1765-0195", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/861a9872844a48718c4b20613099d65a.json"}}, {"family": "Shehab", "given": "Abdulla", "initials": "A", "orcid": "0000-0001-8533-9174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0448033a990d4e08a2736e4efabf90bc.json"}}, {"family": "Mooi", "given": "Ching Siew", "initials": "CS", "orcid": "0000-0002-4425-7989", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9209d3bf7da445ee9e69147c20860be5.json"}}, {"family": "Steckelings", "given": "U Muscha", "initials": "UM", "orcid": "0000-0002-5430-4275", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea42dcd8ea9b4a2c9b4c80bc46c4bccc.json"}}, {"family": "Stergiou", "given": "George", "initials": "G", "orcid": "0000-0002-6132-0038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87b549c63cfa4e5bb947cd868fc7318a.json"}}, {"family": "Touyz", "given": "Rhian M", "initials": "RM", "orcid": "0000-0003-0670-0887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a382d644347d432bbda6ccb135e91cff.json"}}, {"family": "Unger", "given": "Thomas", "initials": "T", "orcid": "0000-0002-0233-8705", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/afdfe83d52034a7481d6ae01a1afbd3a.json"}}, {"family": "Wainford", "given": "Richard D", "initials": "RD", "orcid": "0000-0003-2830-5618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e88bd9e155244c29985b7d5b7acba15.json"}}, {"family": "Wang", "given": "Ji-Guang", "initials": "JG", "orcid": "0000-0001-8511-1524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eafaab42fae54c97860eadc1f1e5e62b.json"}}, {"family": "Williams", "given": "Bryan", "initials": "B", "orcid": "0000-0002-8094-1841", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5491ff3f5d0245728fb17be9d4265105.json"}}, {"family": "Wynne", "given": "Brandi M", "initials": "BM", "orcid": "0000-0003-0861-4245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d76304dc88d74beb923f4bca698e3926.json"}}, {"family": "Tomaszewski", "given": "Maciej", "initials": "M", "orcid": "0000-0001-8215-6567", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f32a5e3c5d544e9a82fc9cc27bbeb9db.json"}}], "type": "journal article", "published": "2023-03-31", "journal": {"title": "Cardiovasc Res", "issn": "1755-3245", "volume": "119", "issue": "2", "pages": "381-409", "issn-l": null}, "abstract": "Raised blood pressure (BP) is the leading cause of preventable death in the world. Yet, its global prevalence is increasing, and it remains poorly detected, treated, and controlled in both high- and low-resource settings. From the perspective of members of the International Society of Hypertension based in all regions, we reflect on the past, present, and future of hypertension care, highlighting key challenges and opportunities, which are often region-specific. We report that most countries failed to show sufficient improvements in BP control rates over the past three decades, with greater improvements mainly seen in some high-income countries, also reflected in substantial reductions in the burden of cardiovascular disease and deaths. Globally, there are significant inequities and disparities based on resources, sociodemographic environment, and race with subsequent disproportionate hypertension-related outcomes. Additional unique challenges in specific regions include conflict, wars, migration, unemployment, rapid urbanization, extremely limited funding, pollution, COVID-19-related restrictions and inequalities, obesity, and excessive salt and alcohol intake. Immediate action is needed to address suboptimal hypertension care and related disparities on a global scale. We propose a Global Hypertension Care Taskforce including multiple stakeholders and societies to identify and implement actions in reducing inequities, addressing social, commercial, and environmental determinants, and strengthening health systems implement a well-designed customized quality-of-care improvement framework.", "doi": "10.1093/cvr/cvac130", "pmid": "36219457", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9619669"}, {"db": "pii", "key": "6758338"}], "notes": [], "created": "2023-04-12T16:46:53.765Z", "modified": "2023-04-12T16:46:54.891Z"}, {"entity": "publication", "iuid": "22e21e095c774dbaa7909cee0507b0d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/22e21e095c774dbaa7909cee0507b0d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/22e21e095c774dbaa7909cee0507b0d0"}}, "title": "The COPE Staff study: Study description and initial report regarding job satisfaction, work-life conflicts, stress, and burnout among Swedish maternal and neonatal healthcare workers during the COVID-19 pandemic.", "authors": [{"family": "Akerstrom", "given": "Magnus", "initials": "M", "orcid": "0000-0002-8469-6193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89ae0148df6f40cfbd1e490e317f1b03.json"}}, {"family": "Sengpiel", "given": "Verena", "initials": "V", "orcid": "0000-0002-3608-7430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d43b587b94df49f88177d0c804ba7688.json"}}, {"family": "Had\u017eibajramovi\u0107", "given": "Emina", "initials": "E", "orcid": "0000-0002-6630-8898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e56ec24563742ac987a8f5d042a1ade.json"}}, {"family": "Carlsson", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-1414-7279", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2453802e12b43008382f79aebd51ddf.json"}}, {"family": "Graner", "given": "Sofie", "initials": "S", "orcid": "0000-0003-1355-9973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e73c3b5e31c4786b42e33a47db0e82e.json"}}, {"family": "Andersson", "given": "Ola", "initials": "O", "orcid": "0000-0002-3972-0457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77b8a87b252041f094508255b8a43df5.json"}}, {"family": "Jonsson", "given": "Maria", "initials": "M", "orcid": "0000-0002-2657-1958", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ef5424eb68f4181bce3b27c17bbe964.json"}}, {"family": "Naurin", "given": "Elin", "initials": "E", "orcid": "0000-0002-7091-994X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54a0a859d7dc428289d8e60b7e90c125.json"}}, {"family": "Veje", "given": "Malin", "initials": "M", "orcid": "0000-0001-5487-0616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de2e59c2ebcf41759a06fda11b6572bd.json"}}, {"family": "Wessberg", "given": "Anna", "initials": "A", "orcid": "0000-0001-8457-9651", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69ed0ec2bf404955acf6d8735166e6db.json"}}, {"family": "Linden", "given": "Karolina", "initials": "K", "orcid": "0000-0002-2792-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a16575cbdf5a4e0ebab52acaf2404273.json"}}], "type": "journal article", "published": "2023-03-30", "journal": {"title": "Int J Gynaecol Obstet", "issn": "1879-3479", "issn-l": null}, "abstract": "To describe the study design of the COPE Staff cohort study on working conditions for maternal and neonatal healthcare workers (MNHCWs), and present baseline data regarding job satisfaction, work-life conflicts, stress, and burnout.\n\nBetween January and April 2021, 957 MNHCWs (administrative and medical staff) completed a baseline survey. Average levels of job satisfaction, work-life conflicts, stress, and burnout, and associations to perceived workload were assessed.\n\nThe average levels of job satisfaction, work-life conflicts, stress, and burnout were 68.6 (95% confidence interval [CI] 64.3-72.8), 42.6 (95% CI 37.3-48.0), 42.0 (95% CI 37.7-46.3), and 1.9 (95% CI 1.6-2.2), respectively. The respondents scoring above critical values indicating clinical burnout ranged between 3% and 18%, respectively, for the four burnout sub-dimensions. Women reported significantly higher levels of stress and burnout. Younger participants had lower job satisfaction and higher levels of work-life conflicts, stress, and burnout. Higher perceived workload was significantly associated with lower job satisfaction levels and higher levels of work-life conflicts, stress, and burnout.\n\nOur results indicate associations between MNHCWs perceived workload and job satisfaction, work-life conflicts, stress, and burnout during the COVID-19 pandemic. Eighteen percent scored above critical values for exhaustion.", "doi": "10.1002/ijgo.14772", "pmid": "36998146", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-21T15:51:23.619Z", "modified": "2023-04-21T15:51:23.853Z"}, {"entity": "publication", "iuid": "5e1ae5bfc1894e15b2929ce6df1089bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e1ae5bfc1894e15b2929ce6df1089bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e1ae5bfc1894e15b2929ce6df1089bf"}}, "title": "Process development for an effective COVID-19 vaccine candidate harboring recombinant SARS-CoV-2 delta plus receptor binding domain produced by Pichia pastoris.", "authors": [{"family": "Kalyoncu", "given": "Sibel", "initials": "S"}, {"family": "Yilmaz", "given": "Semiramis", "initials": "S"}, {"family": "Kuyucu", "given": "Ayca Zeybek", "initials": "AZ"}, {"family": "Sayili", "given": "Dogu", "initials": "D"}, {"family": "Mert", "given": "Olcay", "initials": "O"}, {"family": "Soyturk", "given": "Hakan", "initials": "H"}, {"family": "Gullu", "given": "Seyda", "initials": "S"}, {"family": "Akinturk", "given": "Huseyin", "initials": "H"}, {"family": "Citak", "given": "Erhan", "initials": "E"}, {"family": "Arslan", "given": "Merve", "initials": "M"}, {"family": "Taskinarda", "given": "Melda Guray", "initials": "MG"}, {"family": "Tarman", "given": "Ibrahim Oguzhan", "initials": "IO"}, {"family": "Altun", "given": "Gizem Yilmazer", "initials": "GY"}, {"family": "Ozer", "given": "Ceren", "initials": "C"}, {"family": "Orkut", "given": "Ridvan", "initials": "R"}, {"family": "Demirtas", "given": "Aysegul", "initials": "A"}, {"family": "Tilmensagir", "given": "Idil", "initials": "I"}, {"family": "Keles", "given": "Umur", "initials": "U"}, {"family": "Ulker", "given": "Ceren", "initials": "C"}, {"family": "Aralan", "given": "Gizem", "initials": "G"}, {"family": "Mercan", "given": "Yavuz", "initials": "Y"}, {"family": "Ozkan", "given": "Muge", "initials": "M"}, {"family": "Caglar", "given": "Hasan Onur", "initials": "HO"}, {"family": "Arik", "given": "Gizem", "initials": "G"}, {"family": "Ucar", "given": "Mehmet Can", "initials": "MC"}, {"family": "Yildirim", "given": "Muzaffer", "initials": "M"}, {"family": "Yildirim", "given": "Tugce Canavar", "initials": "TC"}, {"family": "Karadag", "given": "Dilara", "initials": "D"}, {"family": "Bal", "given": "Erhan", "initials": "E"}, {"family": "Erdogan", "given": "Aybike", "initials": "A"}, {"family": "Senturk", "given": "Serif", "initials": "S"}, {"family": "Uzar", "given": "Serdar", "initials": "S"}, {"family": "Enul", "given": "Hakan", "initials": "H"}, {"family": "Adiay", "given": "Cumhur", "initials": "C"}, {"family": "Sarac", "given": "Fahriye", "initials": "F"}, {"family": "Ekiz", "given": "Arzu Tas", "initials": "AT"}, {"family": "Abaci", "given": "Irem", "initials": "I"}, {"family": "Aksoy", "given": "Ozge", "initials": "O"}, {"family": "Polat", "given": "Hivda Ulbegi", "initials": "HU"}, {"family": "Tekin", "given": "Saban", "initials": "S"}, {"family": "Dimitrov", "given": "Stefan", "initials": "S"}, {"family": "Ozkul", "given": "Aykut", "initials": "A"}, {"family": "Wingender", "given": "Gerhard", "initials": "G"}, {"family": "Gursel", "given": "Ihsan", "initials": "I"}, {"family": "Ozturk", "given": "Mehmet", "initials": "M"}, {"family": "Inan", "given": "Mehmet", "initials": "M"}], "type": "journal article", "published": "2023-03-30", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "13", "issue": "1", "pages": "5224", "issn-l": "2045-2322"}, "abstract": "Recombinant protein-based SARS-CoV-2 vaccines are needed to fill the vaccine equity gap. Because protein-subunit based vaccines are easier and cheaper to produce and do not require special storage/transportation conditions, they are suitable for low-/middle-income countries. Here, we report our vaccine development studies with the receptor binding domain of the SARS-CoV-2 Delta Plus strain (RBD-DP) which caused increased hospitalizations compared to other variants. First, we expressed RBD-DP in the Pichia pastoris yeast system and upscaled it to a 5-L fermenter for production. After three-step purification, we obtained RBD-DP with > 95% purity from a protein yield of > 1 g/L of supernatant. Several biophysical and biochemical characterizations were performed to confirm its identity, stability, and functionality. Then, it was formulated in different contents with Alum and CpG for mice immunization. After three doses of immunization, IgG titers from sera reached to > 106 and most importantly it showed high T-cell responses which are required for an effective vaccine to prevent severe COVID-19 disease. A live neutralization test was performed with both the Wuhan strain (B.1.1.7) and Delta strain (B.1.617.2) and it showed high neutralization antibody content for both strains. A challenge study with SARS-CoV-2 infected K18-hACE2 transgenic mice showed good immunoprotective activity with no viruses in the lungs and no lung inflammation for all immunized mice.", "doi": "10.1038/s41598-023-32021-9", "pmid": "36997624", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10062263"}, {"db": "pii", "key": "10.1038/s41598-023-32021-9"}], "notes": [], "created": "2023-04-21T15:51:40.550Z", "modified": "2023-04-21T15:51:40.564Z"}, {"entity": "publication", "iuid": "3879a05a22354ef2a29861a97ec1b3aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3879a05a22354ef2a29861a97ec1b3aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3879a05a22354ef2a29861a97ec1b3aa"}}, "title": "Long-COVID fatigue is not predicted by pre-pandemic plasma IL-6 levels in mild COVID-19.", "authors": [{"family": "Freidin", "given": "Maxim B", "initials": "MB"}, {"family": "Cheetham", "given": "Nathan", "initials": "N"}, {"family": "Duncan", "given": "Emma L", "initials": "EL"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Doores", "given": "Katherine J", "initials": "KJ"}, {"family": "Malim", "given": "Michael H", "initials": "MH"}, {"family": "Rossi", "given": "Niccolo", "initials": "N"}, {"family": "Lord", "given": "Janet M", "initials": "JM"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Borsini", "given": "Alessandra", "initials": "A"}, {"family": "Granville Smith", "given": "Isabelle", "initials": "I"}, {"family": "Falchi", "given": "Mario", "initials": "M"}, {"family": "Pariante", "given": "Carmine", "initials": "C"}, {"family": "Williams", "given": "Frances M K", "initials": "FMK"}], "type": "journal article", "published": "2023-03-30", "journal": {"title": "Inflamm Res", "issn": "1420-908X", "pages": "1-7", "issn-l": null}, "abstract": "Fatigue is a prominent symptom in the general population and may follow viral infection, including SARS-CoV2 infection which causes COVID-19. Chronic fatigue lasting more than three months is the major symptom of the post-COVID syndrome (known colloquially as long-COVID). The mechanisms underlying long-COVID fatigue are unknown. We hypothesized that the development of long-COVID chronic fatigue is driven by the pro-inflammatory immune status of an individual prior to COVID-19.\n\nWe analyzed pre-pandemic plasma levels of IL-6, which plays a key role in persistent fatigue, in N = 1274 community dwelling adults from TwinsUK. Subsequent COVID-19-positive and -negative participants were categorized based on SARS-CoV-2 antigen and antibody testing. Chronic fatigue was assessed using the Chalder Fatigue Scale.\n\nCOVID-19-positive participants exhibited mild disease. Chronic fatigue was a prevalent symptom among this population and significantly higher in positive vs. negative participants (17% vs 11%, respectively; p = 0.001). The qualitative nature of chronic fatigue as determined by individual questionnaire responses was similar in positive and negative participants. Pre-pandemic plasma IL-6 levels were positively associated with chronic fatigue in negative, but not positive individuals. Raised BMI was associated with chronic fatigue in positive participants.\n\nPre-existing increased IL-6 levels may contribute to chronic fatigue symptoms, but there was no increased risk in individuals with mild COVID-19 compared with uninfected individuals. Elevated BMI also increased the risk of chronic fatigue in mild COVID-19, consistent with previous reports.", "doi": "10.1007/s00011-023-01722-2", "pmid": "36995412", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC10062244"}, {"db": "pii", "key": "10.1007/s00011-023-01722-2"}], "notes": [], "created": "2023-04-21T15:53:33.264Z", "modified": "2023-04-21T15:53:33.267Z"}, {"entity": "publication", "iuid": "0922dd1fd6c24abeab55bc0f7ba26b71", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0922dd1fd6c24abeab55bc0f7ba26b71.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0922dd1fd6c24abeab55bc0f7ba26b71"}}, "title": "Gambling and COVID-19: Swedish national gambling data from a state-owned gambling sports and casino operator.", "authors": [{"family": "Balem", "given": "Marianne", "initials": "M", "orcid": "0000-0002-0324-9579", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0413ef1f13d641c98a0de555c4aad642.json"}}, {"family": "Karlsson", "given": "Anna", "initials": "A", "orcid": "0000-0003-1131-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64c210d9f92940ca9860021e69e56a0b.json"}}, {"family": "Widinghoff", "given": "Carolina", "initials": "C", "orcid": "0000-0002-7810-7065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0a6a5a969444d7b8d27a30090c3216e.json"}}, {"family": "Perrot", "given": "Bastien", "initials": "B", "orcid": "0000-0002-3701-6693", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33acfaa75f8549998703777c8269dcf9.json"}}, {"family": "Challet-Bouju", "given": "Ga\u00eblle", "initials": "G", "orcid": "0000-0002-2238-8005", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8363420fee0d48d294ee8e182fe15b08.json"}}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A", "orcid": "0000-0002-5800-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec14ecdcc0654d8ea864f64ce195752b.json"}}], "type": "journal article", "published": "2023-03-30", "journal": {"title": "J Behav Addict", "issn": "2063-5303", "volume": "12", "issue": "1", "pages": "230-241", "issn-l": null}, "abstract": "The lockdown of sports and gambling venues during the coronavirus disease 2019 (COVID-19) pandemic caused a fear of increased gambling on other online gambling types, with a risk for transfer to more addictive gambling than otherwise. This study aimed to estimate changes in gambling activity during COVID-19-affected periods among all gamblers at a Swedish state-owned gambling operator and to analyse observable sex differences.\n\nThis study included gambling tracking data from the Swedish state-owned gambling operator Svenska Spel Sports & Casino (sports betting, online bingo, casino and poker). All individuals (n = 616,245) who gambled at least once from February 10 to July 19, 2020, were included. The study period was divided into four periods according to their expected level of COVID-19 impact on gambling opportunities: one pre-COVID period and three COVID-affected periods (sports cancellation, emerging return of sports, substantial return of sports).\n\nSports betting experienced an apparent decrease, followed by a gradual normalization and an end level substantially below prepandemic levels. For online bingo, gambling levels increased upon sports interruption and then decreased with the return to normality in sports events but remained higher than baseline levels. We observed a similar trend for online poker during the interruption of sports, but with a lower level than baseline levels when sports events normalized. We noticed a trend favouring online casinos during the sports interruption period regarding gambling intensity but not wagering levels.\n\nDramatic changes in the content of the gambling market may divert some gamblers to other gambling types, but maintained effects could not be demonstrated.", "doi": "10.1556/2006.2022.00089", "pmid": "36995980", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-04-21T15:51:54.771Z", "modified": "2023-04-21T15:51:54.989Z"}, {"entity": "publication", "iuid": "fade921f5e854a09b10132d514e27337", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fade921f5e854a09b10132d514e27337.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fade921f5e854a09b10132d514e27337"}}, "title": "The European landscape on allogeneic haematopoeietic cell transplantation in Chronic Lymphocytic Leukaemia between 2009 and 2019: a perspective from the Chronic Malignancies Working Party of the EBMT.", "authors": [{"family": "Tournilhac", "given": "Olivier", "initials": "O", "orcid": "0000-0002-9438-621X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c13ba4e40e4d4297b137a29cddf780f9.json"}}, {"family": "van Gelder", "given": "Michel", "initials": "M"}, {"family": "Eikema", "given": "Dirk-Jan", "initials": "DJ"}, {"family": "Zinger", "given": "Nienke", "initials": "N"}, {"family": "Dreger", "given": "Peter", "initials": "P", "orcid": "0000-0002-7429-8570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4433ddd0ffe348e8ad1495e385e3fd1e.json"}}, {"family": "Bornh\u00e4user", "given": "Martin", "initials": "M"}, {"family": "Vucinic", "given": "Vladan", "initials": "V", "orcid": "0000-0002-8398-285X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9afc2198e04b4d299fa45298534a9b44.json"}}, {"family": "Scheid", "given": "Christof", "initials": "C"}, {"family": "Cornelissen", "given": "Jan J", "initials": "JJ"}, {"family": "Schroeder", "given": "Thomas", "initials": "T"}, {"family": "Jindra", "given": "Pavel", "initials": "P", "orcid": "0000-0002-8415-7069", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7602c74632d04b3b98a5bb0d01f61096.json"}}, {"family": "Sengeloev", "given": "Henrik", "initials": "H"}, {"family": "Nguyen Quoc", "given": "Stephanie", "initials": "S"}, {"family": "Stelljes", "given": "Matthias", "initials": "M"}, {"family": "Blau", "given": "Igor Wolfgang", "initials": "IW"}, {"family": "Mayer", "given": "Jiri", "initials": "J"}, {"family": "Paneesha", "given": "Shankara", "initials": "S"}, {"family": "Chevallier", "given": "Patrice", "initials": "P", "orcid": "0000-0003-3142-5581", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3232eb710cb4a7bb240a5d54f4ef0c8.json"}}, {"family": "Forcade", "given": "Edouard", "initials": "E", "orcid": "0000-0002-8873-2868", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0bfa707a1104de1a132b827238179d4.json"}}, {"family": "Kr\u00f6ger", "given": "Nicolaus", "initials": "N", "orcid": "0000-0001-5103-9966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bcb76aaf69944eb90bff4dce6a4a29f.json"}}, {"family": "Blaise", "given": "Didier", "initials": "D", "orcid": "0000-0002-5684-9447", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09938f98a7bb4e059076c31cb25eabc5.json"}}, {"family": "Gribben", "given": "John", "initials": "J", "orcid": "0000-0002-8505-7430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c243d093ea4a46e68e7d5c1dd052f1b6.json"}}, {"family": "Nielsen", "given": "Bendt", "initials": "B"}, {"family": "Johansson", "given": "Jan-Erik", "initials": "JE"}, {"family": "Kyriakou", "given": "Charalampia", "initials": "C"}, {"family": "Beguin", "given": "Yves", "initials": "Y"}, {"family": "Pioltelli", "given": "Pietro", "initials": "P"}, {"family": "Sampol", "given": "Ant\u00f2nia", "initials": "A", "orcid": "0000-0001-7465-6203", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0345dd93a2514536b82d3c8da6ef87fb.json"}}, {"family": "McLornan", "given": "Donal P", "initials": "DP", "orcid": "0000-0003-1224-091X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c485d00a7f041a184e6863d5d88e4cc.json"}}, {"family": "Schetelig", "given": "Johannes", "initials": "J"}, {"family": "Hayden", "given": "Patrick J", "initials": "PJ", "orcid": "0000-0003-1374-4503", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7cc7cb029ae44d8289498fd80acb6831.json"}}, {"family": "Yakoub-Agha", "given": "Ibrahim", "initials": "I", "orcid": "0000-0003-4524-8782", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/555e2c08de5347fa8ded53ef415ad9d1.json"}}], "type": "journal article", "published": "2023-03-28", "journal": {"title": "Bone Marrow Transplant", "issn": "1476-5365", "pages": "1-4", "issn-l": "0268-3369"}, "abstract": "Allogeneic transplantation (allo-HCT) is a curative treatment in CLL whose efficacy including the most severe forms had led to the 2006 EBMT recommendations. The advent after 2014 of targeted therapies has revolutionized CLL management, allowing prolonged control to patients who have failed immunochemotherapy and/or have TP53 alterations. We analysed the pre COVID pandemic 2009-2019 EBMT registry. The yearly number of allo-HCT raised to 458 in 2011 yet dropped from 2013 onwards to an apparent plateau above 100. Within the 10 countries who were under the EMA for drug approval and performed 83.5% of those procedures, large initial differences were found but the annual number converged to 2-3 per 10 million inhabitants during the 3 most recent years suggesting that allo-HCT remains applied in selected patients. Long-term follow-up on targeted therapies shows that most patients relapse, some early, with risk factors and resistance mechanisms being described. The treatment of patients exposed to both BCL2 and BTK inhibitors and especially those with double refractory disease will become a challenge in which allo-HCT remains a solid option in competition with emerging therapies that have yet to demonstrate their long-term effectiveness.", "doi": "10.1038/s41409-023-01955-z", "pmid": "36977926", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10044103"}, {"db": "pii", "key": "10.1038/s41409-023-01955-z"}], "notes": [], "created": "2023-04-21T15:58:41.357Z", "modified": "2023-04-21T15:58:52.731Z"}, {"entity": "publication", "iuid": "570b29c77de54cf882aad5ca3c22eb43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/570b29c77de54cf882aad5ca3c22eb43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/570b29c77de54cf882aad5ca3c22eb43"}}, "title": "Medical Applications of Nonadditive Entropies.", "authors": [{"family": "Tsallis", "given": "Constantino", "initials": "C", "orcid": "0000-0002-9387-9194", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89cbe0c088dc48f69f0339c432b01c29.json"}}, {"family": "Pasechnik", "given": "Roman", "initials": "R", "orcid": "0000-0003-4231-0149", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce22e54b098840a98f8f0bfafc3f1759.json"}}], "type": "journal article", "published": "2023-03-28", "journal": {"title": "Entropy (Basel)", "issn": "1099-4300", "issn-l": null, "volume": "25", "issue": "4", "pages": null}, "abstract": "The Boltzmann-Gibbs additive entropy SBG=-k\u2211ipilnpi and associated statistical mechanics were generalized in 1988 into nonadditive entropy Sq=k1-\u2211ipiqq-1 and nonextensive statistical mechanics, respectively. Since then, a plethora of medical applications have emerged. In the present review, we illustrate them by briefly presenting image and signal processings, tissue radiation responses, and modeling of disease kinetics, such as for the COVID-19 pandemic.", "doi": "10.3390/e25040578", "pmid": "37190366", "labels": {"Type: Review": null, "Category: Imaging": null}, "xrefs": [{"db": "pmc", "key": "PMC10137456"}, {"db": "pii", "key": "e25040578"}], "notes": [], "created": "2023-10-04T05:11:56.921Z", "modified": "2023-10-04T07:23:35.843Z"}, {"entity": "publication", "iuid": "9a7a008ce380464d8e01b86a3fe63a4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9a7a008ce380464d8e01b86a3fe63a4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9a7a008ce380464d8e01b86a3fe63a4c"}}, "title": "A Case Series on Pregnant Patients with Mild Covid-19 Infection and Signs of Severe Placental Insufficiency.", "authors": [{"family": "Ivert", "given": "A", "initials": "A", "orcid": "0000-0002-3739-1725", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ced16f5a5ab24db6aa5aec2b2c9c12f6.json"}}, {"family": "Lindblad Wollmann", "given": "C", "initials": "C"}, {"family": "Pettersson", "given": "K", "initials": "K"}], "type": "case reports", "published": "2023-03-28", "journal": {"title": "Case Rep Obstet Gynecol", "issn": "2090-6684", "volume": "2023", "pages": "2018551", "issn-l": null}, "abstract": "In this case series, we present five cases of pregnant women who sought medical attention for reduced fetal movements with an ongoing mild maternal Covid-19 infection at a Stockholm hospital in Spring of 2021. At the time of admission, the patients were in gestational week between 24 + 0 and 33 + 5. Abdominal ultrasound at the hospital showed no fetal movements, and cardiotocography (CTG) was pathological. All women delivered via cesarean section within 24 hours after admission. Placental pathology in all cases showed massive perivillous fibrin deposition and extensive histiocytic intervillositis. All placentas were Covid-19 polymerase chain reaction (PCR) positive. The infants were Covid-19 PCR negative. Consistent with other published case reports, we hypothesize that Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect the placenta resulting in massive perivillous fibrin deposition and histiocytic intervillositis leading to acute placental insufficiency and fetal hypoxia. The absence of intrauterine growth restriction also augments the theory of an acute onset of placental insufficiency due to the Covid-19 infection.", "doi": "10.1155/2023/2018551", "pmid": "37025388", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10072962"}], "notes": [], "created": "2023-04-20T17:30:38.579Z", "modified": "2023-04-20T17:30:38.645Z"}, {"entity": "publication", "iuid": "8cb3831d70fc4818aea5cee4def8092f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8cb3831d70fc4818aea5cee4def8092f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8cb3831d70fc4818aea5cee4def8092f"}}, "title": "Sexual and reproductive health in Britain during the first year of the COVID-19 pandemic: cross-sectional population survey (Natsal-COVID-Wave 2) and national surveillance data.", "authors": [{"family": "Mitchell", "given": "Kirstin R", "initials": "KR", "orcid": "0000-0002-4409-6601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2af6a4b606314786806e669e86b92ee0.json"}}, {"family": "Willis", "given": "Malachi", "initials": "M", "orcid": "0000-0002-3173-3990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ca9dea31fdbd4c4db30607d7f3b274fd.json"}}, {"family": "Dema", "given": "Emily", "initials": "E", "orcid": "0000-0002-7254-2023", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3843a1be6fc4e37ac3f8eeff9a2bbb2.json"}}, {"family": "Baxter", "given": "Andrew J", "initials": "AJ", "orcid": "0000-0002-7654-9687", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9814cc9ab7534effba5c569aab450cc4.json"}}, {"family": "Connolly", "given": "Anne", "initials": "A", "orcid": "0000-0003-4953-2182", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65548be760514e228167f010b442043d.json"}}, {"family": "Riddell", "given": "Julie", "initials": "J", "orcid": "0000-0002-8084-4566", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9660f5597db42d19462b83c9f8a1be4.json"}}, {"family": "Bos\u00f3 P\u00e9rez", "given": "Raquel", "initials": "R", "orcid": "0000-0001-7342-4566", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3d61e70a5874b4ea43a1d9d73333605.json"}}, {"family": "Clifton", "given": "Soazig", "initials": "S", "orcid": "0000-0002-4171-0805", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7cea96a2c56409dab9f474144303c30.json"}}, {"family": "Gibbs", "given": "Jo", "initials": "J", "orcid": "0000-0001-5696-0260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8e88ce8b71e4ae3b03749616b5a9eab.json"}}, {"family": "Tanton", "given": "Clare", "initials": "C", "orcid": "0000-0002-4612-1858", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adf2ed41e93f422aa32a1afe93895bed.json"}}, {"family": "Geary", "given": "Rebecca", "initials": "R", "orcid": "0000-0003-1417-1057", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a696d4c9c6024ce58dbcc443326bf362.json"}}, {"family": "Ratna", "given": "Natasha", "initials": "N", "orcid": "0000-0002-8848-7938", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1913b5456b1044e4a0c3f93aa7405fa7.json"}}, {"family": "Mohammed", "given": "Hamish", "initials": "H", "orcid": "0000-0002-2060-7286", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54be4ca28b4b44f7939f51de5f34077c.json"}}, {"family": "Unemo", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1710-2081", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed8c616c8c16456590342443393553cb.json"}}, {"family": "Bonell", "given": "Christopher", "initials": "C", "orcid": "0000-0002-6253-6498", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eeec7c46459414a974c9f42cc3b2baa.json"}}, {"family": "Copas", "given": "Andrew", "initials": "A", "orcid": "0000-0001-8968-5963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0aee9dde1bb2497398a63252a713c88a.json"}}, {"family": "Sonnenberg", "given": "Pam", "initials": "P", "orcid": "0000-0002-1067-1583", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/703eb395b191407eb977ed908453cb30.json"}}, {"family": "Mercer", "given": "Catherine H", "initials": "CH", "orcid": "0000-0002-4220-5034", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6332e0448a8b49c7ab019b7c75768df1.json"}}, {"family": "Field", "given": "Nigel", "initials": "N", "orcid": "0000-0002-2825-6652", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a84330facf864cfe9a4a51550cea9543.json"}}], "type": "journal article", "published": "2023-03-27", "journal": {"title": "Sex Transm Infect", "issn": "1472-3263", "issn-l": "1368-4973"}, "abstract": "To assess sexual behaviour, and sexual and reproductive health (SRH) outcomes, after 1 year of the COVID-19 pandemic in Britain.\n\n6658 participants aged 18-59 and resident in Britain completed a cross-sectional web-panel survey (Natsal-COVID-Wave 2, March-April 2021), 1 year after the first lockdown. Natsal-COVID-2 follows the Natsal-COVID-Wave 1 survey (July-August 2020) which captured impacts in the initial months. Quota-based sampling and weighting resulted in a quasi-representative population sample. Data were contextualised with reference to the most recent probability sample population data (Natsal-3; collected 2010-12; 15 162 participants aged 16-74) and national surveillance data on recorded sexually transmitted infection (STI) testing, conceptions, and abortions in England/Wales (2010-2020). The main outcomes were: sexual behaviour; SRH service use; pregnancy, abortion and fertility management; sexual dissatisfaction, distress and difficulties.\n\nIn the year from the first lockdown, over two-thirds of participants reported one or more sexual partners (women 71.8%; men 69.9%), while fewer than 20.0% reported a new partner (women 10.4%; men 16.8%). Median occasions of sex per month was two. Compared with 2010-12 (Natsal-3), we found less sexual risk behaviour (lower reporting of multiple partners, new partners, and new condomless partners), including among younger participants and those reporting same-sex behaviour. One in 10 women reported a pregnancy; pregnancies were fewer than in 2010-12 and less likely to be scored as unplanned. 19.3% of women and 22.8% of men were distressed or worried about their sex life, significantly more than in 2010-12. Compared with surveillance trends from 2010 to 2019, we found lower than expected use of STI-related services and HIV testing, lower levels of chlamydia testing, and fewer conceptions and abortions.\n\nOur findings are consistent with significant changes in sexual behaviour, SRH, and service uptake in the year following the first lockdown in Britain. These data are foundational to SRH recovery and policy planning.", "doi": "10.1136/sextrans-2022-055680", "pmid": "36973042", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "sextrans-2022-055680"}], "notes": [], "created": "2023-04-21T15:59:49.563Z", "modified": "2023-04-21T15:59:49.823Z"}, {"entity": "publication", "iuid": "a074c5ca733b4ae4896ac4c4e4adb77a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a074c5ca733b4ae4896ac4c4e4adb77a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a074c5ca733b4ae4896ac4c4e4adb77a"}}, "title": "Proteomic characteristics and diagnostic potential of exhaled breath particles in patients with COVID-19.", "authors": [{"family": "Hirdman", "given": "Gabriel", "initials": "G"}, {"family": "Bod\u00e9n", "given": "Embla", "initials": "E"}, {"family": "Kjellstr\u00f6m", "given": "Sven", "initials": "S"}, {"family": "Fraenkel", "given": "Carl-Johan", "initials": "CJ"}, {"family": "Olm", "given": "Franziska", "initials": "F"}, {"family": "Hallgren", "given": "Oskar", "initials": "O"}, {"family": "Lindstedt", "given": "Sandra", "initials": "S"}], "type": "journal article", "published": "2023-03-27", "journal": {"title": "Clin Proteomics", "issn": "1542-6416", "volume": "20", "issue": "1", "pages": "13", "issn-l": null}, "abstract": "SARS-CoV-2 has been shown to predominantly infect the airways and the respiratory tract and too often have an unpredictable and different pathologic pattern compared to other respiratory diseases. Current clinical diagnostical tools in pulmonary medicine expose patients to harmful radiation, are too unspecific or even invasive. Proteomic analysis of exhaled breath particles (EBPs) in contrast, are non-invasive, sample directly from the pathological source and presents as a novel explorative and diagnostical tool.\n\nPatients with PCR-verified COVID-19 infection (COV-POS, n = 20), and patients with respiratory symptoms but with > 2 negative polymerase chain reaction (PCR) tests (COV-NEG, n = 16) and healthy controls (HCO, n = 12) were prospectively recruited. EBPs were collected using a \"particles in exhaled air\" (PExA 2.0) device. Particle per exhaled volume (PEV) and size distribution profiles were compared. Proteins were analyzed using liquid chromatography-mass spectrometry. A random forest machine learning classification model was then trained and validated on EBP data achieving an accuracy of 0.92.\n\nSignificant increases in PEV and changes in size distribution profiles of EBPs was seen in COV-POS and COV-NEG compared to healthy controls. We achieved a deep proteome profiling of EBP across the three groups with proteins involved in immune activation, acute phase response, cell adhesion, blood coagulation, and known components of the respiratory tract lining fluid, among others. We demonstrated promising results for the use of an integrated EBP biomarker panel together with particle concentration for diagnosis of COVID-19 as well as a robust method for protein identification in EBPs.\n\nOur results demonstrate the promising potential for the use of EBP fingerprints in biomarker discovery and for diagnosing pulmonary diseases, rapidly and non-invasively with minimal patient discomfort.", "doi": "10.1186/s12014-023-09403-2", "pmid": "36967377", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10040313"}, {"db": "pii", "key": "10.1186/s12014-023-09403-2"}], "notes": [], "created": "2023-04-21T16:02:51.349Z", "modified": "2023-04-21T16:03:10.432Z"}, {"entity": "publication", "iuid": "d6b973d57dd049d3a1c9caa7041b4b4f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d6b973d57dd049d3a1c9caa7041b4b4f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d6b973d57dd049d3a1c9caa7041b4b4f"}}, "title": "Flares in autoimmune rheumatic diseases in the post-COVID-19 vaccination period - A Cross-sequential study based on COVAD surveys.", "authors": [{"family": "Jagtap", "given": "Kshitij", "initials": "K", "orcid": "0000-0003-2729-737X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822b9da98e5d4eb2975ff97fe484933f.json"}}, {"family": "R", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Vaidya", "given": "Binit", "initials": "B", "orcid": "0000-0002-4840-8924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b2296d53fe14fc7a8415f26e03e1944.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-0986-8354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2e6226ae5e7427fbf52e180dd14e28f.json"}}, {"family": "Saha", "given": "Sreoshy", "initials": "S", "orcid": "0000-0001-6745-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00238845dd4833ae51ffb75e2fe144.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Edgar Gracia-Ramos", "given": "Abraham", "initials": "A", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}, {"family": "Patel", "given": "Aarat", "initials": "A"}, {"family": "Pauling", "given": "John D", "initials": "JD", "orcid": "0000-0002-2793-2364", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e37709273d404d17a88c7c850777b99f.json"}}, {"family": "Wincup", "given": "Chris", "initials": "C", "orcid": "0000-0002-8742-8311", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a674f02e7f7f45f58167eb24f81502f3.json"}}, {"family": "Barman", "given": "Bhupen", "initials": "B", "orcid": "0000-0002-5433-1310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7747785ec5fa4743bc70bd20fbca10fd.json"}}, {"family": "Zamora Tehozol", "given": "Erick Adrian", "initials": "EA", "orcid": "0000-0002-7888-3961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a55c695ac4f4003993a2f511cca7739.json"}}, {"family": "Serrano", "given": "Jorge Rojas", "initials": "JR", "orcid": "0000-0001-6980-7898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/225fd8b396ac40f4a77f1ec229c086b6.json"}}, {"family": "Garc\u00eda-De La Torre", "given": "Ignacio", "initials": "I", "orcid": "0000-0002-9261-678X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/086b85d66fb84b50bd51bbe5a979dfe3.json"}}, {"family": "Colunga-Pedraza", "given": "Iris J", "initials": "IJ", "orcid": "0000-0002-2786-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50e46ef2c7f44b39a1d28fea6a8e621d.json"}}, {"family": "Merayo-Chalico", "given": "Javier", "initials": "J", "orcid": "0000-0002-5870-0523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d74c0ab33cbe4df586e1a1add37d0e65.json"}}, {"family": "Chibuzo", "given": "Okwara Celestine", "initials": "OC", "orcid": "0000-0002-7727-5657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f415c3f3dea49cb90ae12def4278f00.json"}}, {"family": "Katchamart", "given": "Wanruchada", "initials": "W", "orcid": "0000-0002-8952-5967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9439933b38fb49aca8fdbb5038ff603c.json"}}, {"family": "Goo", "given": "Phonpen Akawatcharangura", "initials": "PA"}, {"family": "Shumnalieva", "given": "Russka", "initials": "R", "orcid": "0000-0003-2321-6536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/933232cd7feb48ee81b5971f01f52e23.json"}}, {"family": "Chen", "given": "Yi-Ming", "initials": "YM", "orcid": "0000-0001-7593-3065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/795f1bf1d4824521a3301f7c50f62bc4.json"}}, {"family": "Hoff", "given": "Leonardo Santos", "initials": "LS", "orcid": "0000-0002-2083-4796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1df7af8caf024ca39c57278fdf18c766.json"}}, {"family": "El Kibbi", "given": "Lina", "initials": "L", "orcid": "0000-0003-1710-9996", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11bb4fc524264c6897dec9642a0ef7cd.json"}}, {"family": "Halabi", "given": "Hussein", "initials": "H", "orcid": "0000-0002-5174-8292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb337090a5ab4461a07e8620bee1b4b9.json"}}, {"family": "Sazliyana Shaharir", "given": "Syahrul", "initials": "S", "orcid": "0000-0002-9068-8114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1e6310979d44d58b548c61c733412af.json"}}, {"family": "Hasan", "given": "A T M Tanveer", "initials": "ATMT", "orcid": "0000-0002-5332-3319", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ffdb3329292438fac4005923ee79012.json"}}, {"family": "Dey", "given": "Dzifa", "initials": "D", "orcid": "0000-0002-3339-5112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2615e43aeba34a0585679bdd14a1a324.json"}}, {"family": "Guti\u00e9rrez", "given": "Carlos Enrique Toro", "initials": "CET", "orcid": "0000-0002-6084-7049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/980e455c5d114caaaefb6e0b55eaa3b3.json"}}, {"family": "Caballero-Uribe", "given": "Carlo Vinicio", "initials": "CV", "orcid": "0000-0002-9845-8620", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42d86c9923424f9a804bab4580b993c3.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "COVAD study group", "given": "", "initials": ""}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}], "type": "journal article", "published": "2023-03-24", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "issn-l": null}, "abstract": "Flares of autoimmune rheumatic disease (AIRDs) following COVID-19 vaccination are an outstanding concern in vaccine-hesitant individuals. Therefore, we investigated the incidence, predictors and patterns of flares following vaccination in individuals living with AIRDs using global COVID-19 Vaccination in Autoimmune Diseases (COVAD) surveys.\n\nThe COVAD surveys were used to extract data on flare demographics, comorbidities, COVID-19 history, and vaccination details among patients with AIRDs. Flares following vaccination were identified as patient-reported(a), increased immunosuppression(b), clinical exacerbations(c) and worsening of PROMIS scores(d). We studied flare characteristics and used regression models to differentiate flares among various AIRDs.\n\nOf 15165 total responses, the incidence of flares in 3453 patients with AIRDs was 11.3%, 14.8%, 9.5%, and 26.7% by definitions a-d, respectively. There was moderate agreement between patient-reported and immunosuppression-defined flares (K = 0.403, p = 0.022). Arthritis (61.6%) and fatigue (58.8%) were the most commonly reported symptoms. Self-reported flares were associated with higher comorbidities (p = 0.013), mental health disorders (MHD) (p < 0.001), and autoimmune multimorbidity (AIDm) (p < 0.001).In regression analysis, the presence of AIDm (OR = 1.4;95%CI:1.1-1.7;p=0.003), MHD (OR = 1.7;95%CI:1.1-2.6;p=0.007), and Moderna vaccine (OR = 1.5;95%CI:1.09-2.2;p=0.014) recipients were predictors of flares. Mycophenolate (OR = 0.5;95%CI:0.3-0.8;p=0.009) and glucocorticoids (OR = 0.6;95%CI:0.5-0.8;p=0.003) were protective.A higher frequency of patients with AIRDs reported overall active disease post-vaccination compared to before vaccination (OR = 1.3;95%CI:1.1-1.5;p<0.001).\n\nFlares occur in nearly one in ten individuals with AIRDs after COVID vaccination, with people with comorbidities, especially AID multimorbidity, mental health disorders and use of the Moderna vaccine being particularly vulnerable. Future avenues include exploring flare profiles and optimizing vaccine strategies for this group.", "doi": "10.1093/rheumatology/kead144", "pmid": "36961331", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7085591"}], "notes": [], "created": "2023-04-21T16:03:32.208Z", "modified": "2023-04-21T16:03:32.559Z"}, {"entity": "publication", "iuid": "86e00e5653a54fabbc9a2f6decb2ad37", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86e00e5653a54fabbc9a2f6decb2ad37.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86e00e5653a54fabbc9a2f6decb2ad37"}}, "title": "Syndemic health crises-The growing role of National Public Health Institutes in shaping a coordinated response.", "authors": [{"family": "Tweed", "given": "Sam", "initials": "S", "orcid": "0000-0002-6395-8422", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f2abaf594474ad5a8c3a79edd012803.json"}}, {"family": "Selbie", "given": "Duncan", "initials": "D"}, {"family": "Tegnell", "given": "Anders", "initials": "A"}, {"family": "Viso", "given": "Anne-Catherine", "initials": "AC"}, {"family": "Ahmed", "given": "Abdifatah", "initials": "A"}, {"family": "Mastkov", "given": "Oleksandr", "initials": "O"}, {"family": "Pendergast", "given": "Scott", "initials": "S"}, {"family": "Squires", "given": "Neil", "initials": "N"}], "type": "journal article", "published": "2023-03-23", "journal": {"title": "Int J Health Plann Manage", "issn": "1099-1751", "issn-l": null}, "abstract": "Countries across the world are experiencing syndemic health crises where infectious pathogens including COVID-19 interact with epidemics of communicable and non-communicable diseases. Combined with war, environmental instability and the effects of soaring inflation, a public health crisis has emerged requiring an integrated response. Increasingly, national public health institutes (NPHIs) are at the forefront of leading this, as demonstrated at the 2022 Annual Meeting of the International Association of National Public Health Institutes (IANPHI). These effects are particularly evident where conflict is exacerbating health crises in Ukraine and Somalia. In Ukraine, medical and public health workers have been killed and infrastructure destroyed, which require major efforts to rebuild to international standards. In Somalia, these crises are magnified by the effects of climate change, leading to greater food insecurity, heat-related deaths and famine. National public health institutes are crucial in these contexts and many others to support integrated political responses where health challenges span local, national and international levels and involve multiple stakeholders. This can be seen in strengthening of Integrated Disease Surveillance and work towards the Sustainable Development Goals. National public health institutes also provide integration through the international system, working jointly to build national capacities to deliver essential public health functions. In this context, the 2022 IANPHI Annual meeting agreed the Stockholm Statement, highlighting the role that NPHIs play in tackling the causes and effects of interconnected global and local challenges to public health. This represents an important step in addressing complex health crises and syndemics which require whole-of-society responses, with NPHIs uniquely placed to work across sectors and provide system leadership in response.", "doi": "10.1002/hpm.3634", "pmid": "36959725", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-04-21T16:05:09.001Z", "modified": "2023-04-21T16:05:09.062Z"}, {"entity": "publication", "iuid": "2e4797c19d1e4d4ea6981a7c30418394", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e4797c19d1e4d4ea6981a7c30418394.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e4797c19d1e4d4ea6981a7c30418394"}}, "title": "Involuntary Resistance.", "authors": [{"family": "Baaz", "given": "Mikael", "initials": "M"}, {"family": "Lilja", "given": "Mona", "initials": "M", "orcid": "0000-0003-2773-8534", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9bb2b4cd78b74bab81987a2d1c2ab943.json"}}, {"family": "Wallgren", "given": "Malin", "initials": "M"}], "type": "journal article", "published": "2023-03-23", "journal": {"title": "Int J Polit Cult Soc", "issn": "0891-4486", "issn-l": null, "volume": null, "issue": null, "pages": "1-21"}, "abstract": "This paper problematizes the notion of \"intent\" through the concept of \"involuntary resistance\". Departing from the narratives of employees in nursing homes in Sweden during the Covid-19 pandemic in 2020 and 2021, we suggest that neoliberal norms and a local management that capitalizes on social hierarchies (sex, age, class, etc.) were the context of the strong biopolitical state management that occurred due to the Covid-19 pandemic. The friction between different forms of governing became a seedbed for an involuntary resistance with an unclear intent against the state recommendations. This sheds light upon the need to (re)frame the current dominance of specific types of knowledge that are constructed in the field of resistance. We suggest that new paths of thought are needed-within social sciences-that work towards a wider conceptualizing of resistance, which embraces practices that lie outside the common thought of dissent.", "doi": "10.1007/s10767-023-09442-5", "pmid": "37361706", "labels": {"Category: Social Science & Humanities": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC10034246"}, {"db": "pii", "key": "9442"}], "notes": [], "created": "2023-10-04T09:31:43.756Z", "modified": "2023-10-04T10:52:59.715Z"}, {"entity": "publication", "iuid": "b3ca239b5db743f2a50b5cd6f7e41585", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b3ca239b5db743f2a50b5cd6f7e41585.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b3ca239b5db743f2a50b5cd6f7e41585"}}, "title": "Community participatory learning and action cycle groups to reduce type 2 diabetes in Bangladesh (D:Clare): an updated study protocol for a parallel arm cluster randomised controlled trial.", "authors": [{"family": "King", "given": "Carina", "initials": "C"}, {"family": "Pires", "given": "Malini", "initials": "M"}, {"family": "Ahmed", "given": "Naveed", "initials": "N"}, {"family": "Akter", "given": "Kohenour", "initials": "K"}, {"family": "Kuddus", "given": "Abdul", "initials": "A"}, {"family": "Copas", "given": "Andrew", "initials": "A"}, {"family": "Haghparast-Bidgoli", "given": "Hassan", "initials": "H"}, {"family": "Morrison", "given": "Joanna", "initials": "J"}, {"family": "Nahar", "given": "Tasmin", "initials": "T"}, {"family": "Shaha", "given": "Sanjit Kumer", "initials": "SK"}, {"family": "Khan", "given": "AKAzad", "initials": "A"}, {"family": "Azad", "given": "Kishwar", "initials": "K"}, {"family": "Fottrell", "given": "Edward", "initials": "E", "orcid": "0000-0003-0518-7161", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb5f48cd80b4425984648f889a2a2b45.json"}}], "type": "clinical trial protocol", "published": "2023-03-23", "journal": {"title": "Trials", "issn": "1745-6215", "volume": "24", "issue": "1", "pages": "218", "issn-l": null}, "abstract": "The \"Diabetes: Community-led Awareness, Response and Evaluation\" (D:Clare) trial aims to scale up and replicate an evidence-based participatory learning and action cycle intervention in Bangladesh, to inform policy on population-level T2DM prevention and control.The trial was originally designed as a stepped-wedge cluster randomised controlled trial, with the interventions running from March 2020 to September 2022. Twelve clusters were randomly allocated (1:1) to implement the intervention at months 1 or 12 in two steps, and evaluated through three cross-sectional surveys at months 1, 12 and 24. However, due to the COVID-19 pandemic, we suspended project activities on the 20th of March 2020. As a result of the changed risk landscape and the delays introduced by the COVID-19 pandemic, we changed from the stepped-wedge design to a wait-list parallel arm cluster RCT (cRCT) with baseline data. We had four key reasons for eventually agreeing to change designs: equipoise, temporal bias in exposure and outcomes, loss of power and time and funding considerations.Trial registration ISRCTN42219712 . Registered on 31 October 2019.", "doi": "10.1186/s13063-023-07243-x", "pmid": "36959617", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10034243"}, {"db": "pii", "key": "10.1186/s13063-023-07243-x"}], "notes": [], "created": "2023-04-21T16:05:31.152Z", "modified": "2023-04-21T16:05:31.188Z"}, {"entity": "publication", "iuid": "3c95dafecf78407bbfb32294e1d5700e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3c95dafecf78407bbfb32294e1d5700e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3c95dafecf78407bbfb32294e1d5700e"}}, "title": "Health progression for Covid-19 survivors hospitalized in geriatric clinics in Sweden.", "authors": [{"family": "Kananen", "given": "Laura", "initials": "L", "orcid": "0000-0003-3742-8927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d8f660eb3e4490f8d6d2d12b773d92d.json"}}, {"family": "Hong", "given": "Xu", "initials": "X"}, {"family": "Annetorp", "given": "Martin", "initials": "M"}, {"family": "Mak", "given": "Jonathan K L", "initials": "JKL", "orcid": "0000-0003-4454-8580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4ec879e8b4a4879af61239068143893.json"}}, {"family": "Jylh\u00e4v\u00e4", "given": "Juulia", "initials": "J"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}, {"family": "H\u00e4gg", "given": "Sara", "initials": "S"}, {"family": "Religa", "given": "Dorota", "initials": "D"}], "type": "journal article", "published": "2023-03-22", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "18", "issue": "3", "pages": "e0283344", "issn-l": "1932-6203"}, "abstract": "To analyse if the health progression of geriatric Covid-19 survivors three months after an acute Covid-19 infection was worse than in other geriatric patients. Specifically, we wanted to see if we could see distinct health profiles in the flow of re-admitted Covid-19 patients compared to re-admitted non-Covid-19 controls.\n\nMatched cohort study.\n\nElectronic medical records of geriatric patients hospitalised in geriatric clinics in Stockholm, Sweden, between March 2020 and January 2022. Patients readmitted three months after initial admission were selected for the analysis and Covid-19 survivors (n = 895) were compared to age-sex-Charlson comorbidity index (CCI)-matched non-Covid-19 controls (n = 2685).\n\nWe assessed using binary logistic and Cox regression if a previous Covid-19 infection could be a risk factor for worse health progression indicated by the CCI, hospital frailty risk score (HFRS), mortality and specific comorbidities.\n\nThe patients were mostly older than 75 years and, already at baseline, had typically multiple comorbidities. The Covid-19 patients with readmission had mostly had their acute-phase infection in the 1st or 2nd pandemic waves before the vaccinations. The Covid-19 patients did not have worse health after three months compared to the matched controls according to the CCI (odds ratio, OR[95% confidence interval, CI] = 1.12[0.94-1.34]), HFRS (OR[95%CI] = 1.05[0.87-1.26]), 6-months (hazard ratio, HR[95%CI] = 1.04[0.70-1.52]) and 1-year-mortality risk (HR[95%CI] = 0.89[0.71-1.10]), adjusted for age, sex and health at baseline (the CCI and HFRS).\n\nThe overall health progression of re-hospitalized geriatric Covid-19 survivors did not differ dramatically from other re-hospitalized geriatric patients with similar age, sex and health at baseline. Our results emphasize that Covid-19 was especially detrimental for geriatric patients in the acute-phase, but not in the later phase. Further studies including post-vaccination samples are needed.", "doi": "10.1371/journal.pone.0283344", "pmid": "36947542", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10032538"}, {"db": "pii", "key": "PONE-D-22-21870"}], "notes": [], "created": "2023-04-21T16:06:57.286Z", "modified": "2023-04-21T16:06:57.365Z"}, {"entity": "publication", "iuid": "3f8d510834ab41f097f8cfa99a8c238f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f8d510834ab41f097f8cfa99a8c238f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f8d510834ab41f097f8cfa99a8c238f"}}, "title": "Correlates of protection and viral load trajectories in omicron breakthrough infections in triple vaccinated healthcare workers.", "authors": [{"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Norin", "given": "Nina Greilert", "initials": "NG"}, {"family": "Bladh", "given": "Oscar", "initials": "O"}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f2dc27d02294a15a6f691be6aab641f.json"}}, {"family": "Gordon", "given": "Max", "initials": "M", "orcid": "0000-0002-8080-5815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b07b91dec1424185a3e8ee6c8bbf00d7.json"}}, {"family": "Ng", "given": "Henry", "initials": "H"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Phillipson", "given": "Mia", "initials": "M", "orcid": "0000-0002-2387-0266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/614a4a6f69204c6287a81a79a1a7a8f1.json"}}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "Alm", "given": "Jessica J", "initials": "JJ"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2023-03-22", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "1577", "issn-l": "2041-1723"}, "abstract": "Vaccination offers protection against severe COVID-19 caused by SARS-CoV-2 omicron but is less effective against infection. Characteristics such as serum antibody titer correlation to protection, viral abundance and clearance of omicron infection in vaccinated individuals are scarce. We present a 4-week twice-weekly SARS-CoV-2 qPCR screening in 368 triple vaccinated healthcare workers. Spike-specific IgG levels, neutralization titers and mucosal spike-specific IgA-levels were determined at study start and qPCR-positive participants were sampled repeatedly for two weeks. 81 (cumulative incidence 22%) BA.1, BA.1.1 and BA.2 infections were detected. High serum antibody titers are shown to be protective against infection (p < 0.01), linked to reduced viral load (p < 0.01) and time to viral clearance (p < 0.05). Pre-omicron SARS-CoV-2 infection is independently associated to increased protection against omicron, largely mediated by mucosal spike specific IgA responses (nested models lr test p = 0.02 and 0.008). Only 10% of infected participants remain asymptomatic through the course of their infection. We demonstrate that high levels of vaccine-induced spike-specific WT antibodies are linked to increased protection against infection and to reduced viral load if infected, and suggest that the additional protection offered by pre-omicron SARS-CoV-2 infection largely is mediated by mucosal spike-specific IgA.", "doi": "10.1038/s41467-023-36984-1", "pmid": "36949041", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Omicron VoC": null}, "xrefs": [{"db": "pmc", "key": "PMC10031702"}, {"db": "pii", "key": "10.1038/s41467-023-36984-1"}], "notes": [], "created": "2023-04-21T16:06:33.901Z", "modified": "2023-06-19T14:26:54.012Z"}, {"entity": "publication", "iuid": "0f8947530b744d4286909af61fbb33c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0f8947530b744d4286909af61fbb33c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0f8947530b744d4286909af61fbb33c5"}}, "title": "Clinical pathway of COVID-19 patients in primary health care in 30 European countries: Eurodata study.", "authors": [{"family": "Ares-Blanco", "given": "Sara", "initials": "S", "orcid": "0000-0002-4984-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5929b4be5ff946a2af9b33fde3fb09ec.json"}}, {"family": "Guisado-Clavero", "given": "Marina", "initials": "M", "orcid": "0000-0002-8448-2929", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe6cb00ce6e64ea9ae551a4a65c1093c.json"}}, {"family": "Ramos Del Rio", "given": "Lourdes", "initials": "L", "orcid": "0000-0003-4850-2053", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/629e28d8cf1d4ba3926ba037e14f5742.json"}}, {"family": "Gefaell Larrondo", "given": "Ileana", "initials": "I", "orcid": "0000-0002-1635-1003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a6e202b315e4966a1fc58919d4f4e4e.json"}}, {"family": "Fitzgerald", "given": "Louise", "initials": "L", "orcid": "0009-0009-8039-3097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54a11aeb7912445e91a8861314dc9dc3.json"}}, {"family": "Adler", "given": "Limor", "initials": "L", "orcid": "0000-0002-9335-6596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d78ad3257d4a4337b7dcdf9922159290.json"}}, {"family": "Assenova", "given": "Radost", "initials": "R", "orcid": "0000-0003-2158-5792", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ded85b8b782e4e58aef1767e73bd5c8e.json"}}, {"family": "Bakola", "given": "Maria", "initials": "M", "orcid": "0000-0002-9016-9322", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6da94c24ddbe4917aba9f082cc0de1c0.json"}}, {"family": "Bayen", "given": "Sabine", "initials": "S", "orcid": "0000-0002-3334-9394", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/97df8a37f1314326b345c4d55fe81941.json"}}, {"family": "Brutskaya-Stempkovskaya", "given": "Elena", "initials": "E"}, {"family": "Busneag", "given": "Iliana-Carmen", "initials": "IC", "orcid": "0000-0001-5611-4312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/980a841d76cd48ed81d4187314a10e3f.json"}}, {"family": "Domeyer", "given": "Philippe-Richard", "initials": "PR", "orcid": "0000-0003-4594-1202", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/223b4565009340998b3fb347d5d62450.json"}}, {"family": "Gjorgjievski", "given": "Dragan", "initials": "D", "orcid": "0000-0003-1817-7632", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/196c52fd9c7c4214a6ae708ed49aa08e.json"}}, {"family": "Hoffmann", "given": "Kathryn", "initials": "K", "orcid": "0000-0001-8760-4250", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/97efc06959c84715a62389edbb78f5d6.json"}}, {"family": "\u0406\u043b\u044c\u043a\u043e\u0432", "given": "\u041e\u043a\u0441\u0430\u043d\u0430", "initials": "\u041e", "orcid": "0000-0002-0923-0596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3902996bf15440c4b6f9491b17d40e61.json"}}, {"family": "Trifon Karathanos", "given": "Vasilis", "initials": "V"}, {"family": "Kirkovski", "given": "Aleksandar", "initials": "A", "orcid": "0000-0001-9002-7028", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e2e11e53a2444799bb3af8d1c6fd951.json"}}, {"family": "Kne\u017eevi\u0107", "given": "Sne\u017eana", "initials": "S", "orcid": "0000-0001-9137-2122", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d71f49de1734f4cb1d5c8d601d32dec.json"}}, {"family": "\u00c7imen Korkmaz", "given": "B\u00fcsra", "initials": "B", "orcid": "0000-0001-7224-5734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ac217a7408242f7920df89fdc6c053f.json"}}, {"family": "Heleno", "given": "Bruno", "initials": "B", "orcid": "0000-0002-3943-1858", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/298ecb30af3b4dd39acadc195016c729.json"}}, {"family": "Nessler", "given": "Katarzyna", "initials": "K", "orcid": "0000-0001-9869-7923", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b12b696d11b34519b8cb27cd01db009a.json"}}, {"family": "Murauskien\u0117", "given": "Liubov\u0117", "initials": "L", "orcid": "0000-0002-6625-8843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5196c9522ef74c82a5a5efc07196e3e2.json"}}, {"family": "Neves", "given": "Ana Luisa", "initials": "AL", "orcid": "0000-0002-7107-7211", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/313da3100a6143a5bfa50a983b477d59.json"}}, {"family": "Parodi L\u00f3pez", "given": "Naldy", "initials": "N", "orcid": "0000-0001-6367-9389", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf3c3c30eee1498d980d3be9bebd0543.json"}}, {"family": "Perj\u00e9s", "given": "\u00c1bel", "initials": "\u00c1", "orcid": "0000-0002-7176-1275", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7cf2b396ec4430c81bc3f76ac2d070b.json"}}, {"family": "Petek", "given": "Davorina", "initials": "D", "orcid": "0000-0002-0151-4463", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb8c599dfe4a496aa21408f3521ded5e.json"}}, {"family": "Petrazzuoli", "given": "Ferdinando", "initials": "F", "orcid": "0000-0003-1058-492X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50bb7fdd235f46629be48fdff0a5fd6c.json"}}, {"family": "Petricek", "given": "Goranka", "initials": "G", "orcid": "0000-0002-6614-3085", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd2203cac86047658296c405e6173680.json"}}, {"family": "Seifert", "given": "Bohumil", "initials": "B", "orcid": "0000-0002-6881-8840", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64e3433f85084d9499b345eb10e31052.json"}}, {"family": "Serafini", "given": "Alice", "initials": "A", "orcid": "0000-0002-7396-2839", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dfd0165d3afe49f49370124c8a379a81.json"}}, {"family": "Sentker", "given": "Theresa", "initials": "T", "orcid": "0000-0003-1162-310X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bed1b751e47d419fa5c1e86a517a8161.json"}}, {"family": "Tiili", "given": "Paula", "initials": "P", "orcid": "0000-0002-7916-7262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3939d43175b4bddbaf87dea226190fb.json"}}, {"family": "Torzsa", "given": "P\u00e9ter", "initials": "P"}, {"family": "Vaes", "given": "Bert", "initials": "B", "orcid": "0000-0001-5244-1930", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e0e264d183c46d198df84a956aef74f.json"}}, {"family": "van Pottebergh", "given": "Gijs", "initials": "G", "orcid": "0000-0002-4189-3517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c5f6c9a7d294faab488ade63d22a9bb.json"}}, {"family": "Vinker", "given": "Shlomo", "initials": "S", "orcid": "0000-0001-9804-7103", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e8d0c73cfe04e4c8ac85f6429cbb8cf.json"}}, {"family": "Astier-Pe\u00f1a", "given": "Mar\u00eda Pilar", "initials": "MP", "orcid": "0000-0002-3192-7672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/585b3e1ed7df4d63b0342ab0d96ef9c4.json"}}, {"family": "G\u00f3mez-Bravo", "given": "Raquel", "initials": "R", "orcid": "0000-0002-3786-8626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa876914ef4c487aa47e1b3248deaab5.json"}}, {"family": "Lingner", "given": "Heidrun", "initials": "H", "orcid": "0000-0003-2074-0367", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49f1b26a486540968df9724abbce2d0a.json"}}, {"family": "Clinical investigators\u2020", "given": "", "initials": ""}, {"family": "Clinical investigators:", "given": "", "initials": ""}], "type": "journal article", "published": "2023-03-21", "journal": {"title": "Eur J Gen Pract", "issn": "1751-1402", "pages": "2182879", "issn-l": null}, "abstract": "Most COVID-19 patients were treated in primary health care (PHC) in Europe.\n\nTo demonstrate the scope of PHC workflow during the COVID-19 pandemic emphasising similarities and differences of patient's clinical pathways in Europe.\n\nDescriptive, cross-sectional study with data acquired through a semi-structured questionnaire in PHC in 30 European countries, created ad hoc and agreed upon among all researchers who participated in the study. GPs from each country answered the approved questionnaire. Main variable: PHC COVID-19 acute clinical pathway. All variables were collected from each country as of September 2020.\n\nCOVID-19 clinics in PHC facilities were organised in 8/30. Case detection and testing were performed in PHC in 27/30 countries. RT-PCR and lateral flow tests were performed in PHC in 23/30, free of charge with a medical prescription. Contact tracing was performed mainly by public health authorities. Mandatory isolation ranged from 5 to 14 days. Sick leave certification was given exclusively by GPs in 21/30 countries. Patient hotels or other resources to isolate patients were available in 12/30. Follow-up to monitor the symptoms and/or new complementary tests was made mainly by phone call (27/30). Chest X-ray and phlebotomy were performed in PHC in 18/30 and 23/30 countries, respectively. Oxygen and low-molecular-weight heparin were available in PHC (21/30).\n\nIn Europe PHC participated in many steps to diagnose, treat and monitor COVID-19 patients. Differences among countries might be addressed at European level for the management of future pandemics.", "doi": "10.1080/13814788.2023.2182879", "pmid": "36943232", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-21T16:07:52.599Z", "modified": "2023-04-21T16:07:53.683Z"}, {"entity": "publication", "iuid": "28cf59f0fd4c4db099e848d6975b0b18", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/28cf59f0fd4c4db099e848d6975b0b18.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/28cf59f0fd4c4db099e848d6975b0b18"}}, "title": "Antiepileptogenesis after Stroke - Trials and Tribulations: Methodological Challenges and Recruitment Results of a Phase II Study with Eslicarbazepine Acetate.", "authors": [{"family": "Koepp", "given": "Matthias J", "initials": "MJ", "orcid": "0000-0002-4277-8000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/862bbdee43044d5594cce53574a38387.json"}}, {"family": "Trinka", "given": "Eugen", "initials": "E", "orcid": "0000-0002-5950-2692", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1618693eb8bf416e8891ab2931877a89.json"}}, {"family": "Mah", "given": "Yee-Haur", "initials": "YH"}, {"family": "Bentes", "given": "Carla", "initials": "C", "orcid": "0000-0003-2399-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/152174fbb79b40f0be4db0ba5a05a5b1.json"}}, {"family": "Knake", "given": "Susanne", "initials": "S"}, {"family": "Gigli", "given": "Gian Luigi", "initials": "GL"}, {"family": "Serratosa", "given": "Jos\u00e9 M", "initials": "JM"}, {"family": "Zelano", "given": "Johan", "initials": "J", "orcid": "0000-0001-9445-4545", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1188e644aaa41c4841cf6acbc1ee11a.json"}}, {"family": "Magalh\u00e3es", "given": "Lu\u00eds M", "initials": "LM"}, {"family": "Pereira", "given": "Ana", "initials": "A"}, {"family": "Moreira", "given": "Joana", "initials": "J"}, {"family": "Soares-da-Silva", "given": "Patr\u00edcio", "initials": "P", "orcid": "0000-0002-2446-5078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59911af4073b40809de32fdb7c104739.json"}}], "type": "journal article", "published": "2023-03-21", "journal": {"title": "Epilepsia Open", "issn": "2470-9239", "issn-l": null}, "abstract": "There is currently no evidence to support the use of antiseizure medications to prevent unprovoked seizures following stroke. Experimental animal models suggested a potential antiepileptogenic effect for eslicarbazepine acetate (ESL), and a Phase II, multicentre, randomised, double-blind, placebo-controlled study was designed to test this hypothesis and assess whether ESL treatment for 1 month can prevent unprovoked seizures following stroke. We outline the design and status of this antiepileptogenesis study, and discuss the challenges encountered in its execution to date. Patients at high risk of developing unprovoked seizures after acute intracerebral haemorrhage or acute ischaemic stroke were randomised to receive ESL 800 mg/day or placebo, initiated within 120 hours after primary stroke occurrence. Treatment continued until Day 30, then tapered off. Patients could receive all necessary therapies for stroke treatment according to clinical practice guidelines and standard of care, and are being followed up for 18 months. The primary efficacy endpoint is occurrence of a first unprovoked seizure within 6 months after randomisation ('failure rate'). Secondary efficacy assessments include occurrence of a first unprovoked seizure during 12 months after randomisation and during the entire study; functional outcomes (Barthel Index original 10-item version; National Institutes of Health Stroke Scale); post-stroke depression (Patient Health Questionnaire-9; PHQ-9); and overall survival. Safety assessments include evaluation of treatment-emergent adverse events; laboratory parameters; vital signs; electrocardiogram; suicidal ideation and behaviour (PHQ-9 question 9). The protocol aimed to randomise approximately 200 patients (1:1), recruited from 21 sites in seven European countries and Israel. Despite the challenges encountered, particularly during the COVID-19 pandemic, the study progressed and included a remarkable number of patients, with 129 screened and 125 randomised. Recruitment was stopped after 30 months, the first patient entered in May 2019, and the study is ongoing and following up on patients according to the Clinical Trial Protocol.", "doi": "10.1002/epi4.12735", "pmid": "36944588", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-21T16:07:35.824Z", "modified": "2023-04-21T16:07:36.005Z"}, {"entity": "publication", "iuid": "f99416f34ecf45aa935971c0406d6b38", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f99416f34ecf45aa935971c0406d6b38.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f99416f34ecf45aa935971c0406d6b38"}}, "title": "The burden of disease due to COVID-19 in Sweden 2020-2021: A disability-adjusted life years (DALYs) study.", "authors": [{"family": "Shedrawy", "given": "Jad", "initials": "J", "orcid": "0000-0002-2700-0727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b9672a195ee45fea4ed03b72e371df4.json"}}, {"family": "Ernst", "given": "Patricia", "initials": "P"}, {"family": "L\u00f6nnroth", "given": "Knut", "initials": "K", "orcid": "0000-0001-6944-0256", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a9b9783181c4e63a6edf4985c1b299d.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2023-03-20", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "14034948231160616", "issn-l": "1403-4948"}, "abstract": "The burden of COVID-19 disease can be measured in terms of disability-adjusted life years (DALYs), which is composed of two components: the years of life lost through premature death (YLL) and the number of years lived with disability (YLD), adjusted for level of disability. This study measured DALYs due to COVID-19 in Sweden and compared it to the burden of other diseases.\n\nThe methodology used in the calculation of DALYs was based on the Global Burden of Disease guidelines. The number of patients diagnosed with mild/moderate, severe or critical COVID-19 and/or post-COVID-19 condition between March 2020 and October 2021 was extracted from national registries and used for YLD calculations. In addition, the numbers of death due to COVID-19 in different age groups were used for the YLL calculation.\n\nDuring the study period, 152,877 DALYs were lost to COVID-19 in Sweden, 99.3% of which was attributed to YLL. Loss of DALYs occurred mainly among the elderly, with 66.8% of DALYs attributed to individuals >70 years old. Compared to other diseases, the burden of COVID-19 in 2020 ranked as the eighth leading cause of DALY lost.\n\nSimilar to other countries, the burden of COVID-19 in Sweden was concentrated mainly among the elderly, who contributed most of the DALY lost due to premature mortality. Yet, DALY loss remained lower for COVID-19 than for several other diseases. The contribution of YLD to DALYs lost was minimal. However empirical data on the occurrence and disability of post-COVID-19 condition are scarce, and YLD may therefore be underestimated.", "doi": "10.1177/14034948231160616", "pmid": "36941820", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10033504"}], "notes": [], "created": "2023-04-21T16:08:06.283Z", "modified": "2023-04-21T16:08:06.349Z"}, {"entity": "publication", "iuid": "b69a5c3107a1457baeb8447e677bdd8d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b69a5c3107a1457baeb8447e677bdd8d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b69a5c3107a1457baeb8447e677bdd8d"}}, "title": "Prevalence of depression among students at a Sri Lankan University: A study using the Patient Health Questionnaire-9 (PHQ-9) during the COVID-19 pandemic.", "authors": [{"family": "Wickramasinghe", "given": "Ayanthi", "initials": "A"}, {"family": "Ess\u00e9n", "given": "Birgitta", "initials": "B"}, {"family": "Surenthirakumaran", "given": "Rajendra", "initials": "R"}, {"family": "Axemo", "given": "Pia", "initials": "P"}], "type": "journal article", "published": "2023-03-20", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "23", "issue": "1", "pages": "528", "issn-l": null}, "abstract": "The prevalence of mental health disorders is known to be high among university students globally. Currently there are only a few studies on depression among university students in Sri Lanka. The aim of this study was to screen for the prevalence of Major Depressive Disorder (MDD) and other forms of depression, and to evaluate the factors associated with MDD.\n\nA cross sectional survey using the Patient Health Questionnaire (PHQ-9) was conducted among 637, second-year students from the faculties of Management Studies & Commerce, Science and Medicine at the University of Jaffna, during the Coronavirus (COVID-19) pandemic. Bivariate associations were assessed using chi-squared tests. Logistic regression was used to evaluate factors associated with any type of ragging.\n\nMDD was considered to have been experienced by 31% of the students. From all three faculties, 70% of the students claimed to have experienced some form of depression ranging from mild to severe. The factor associated with MDD was the students' ethnicity.\n\nDue to the high MDD risk among university students, it is imperative to develop psychosocial interventions to ensure early detection of mental health disorders and provide adequate support to safeguard this vulnerable population.", "doi": "10.1186/s12889-023-15427-y", "pmid": "36941588", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10026232"}, {"db": "pii", "key": "10.1186/s12889-023-15427-y"}], "notes": [], "created": "2023-04-21T16:08:15.824Z", "modified": "2023-04-21T16:08:15.837Z"}, {"entity": "publication", "iuid": "0e2e7e401ebe4519acc47ee41c2dbb0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e2e7e401ebe4519acc47ee41c2dbb0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e2e7e401ebe4519acc47ee41c2dbb0e"}}, "title": "Physical and mental health impact of the COVID-19 pandemic at first year in a Spanish adult cohort.", "authors": [{"family": "Castellvi Obiols", "given": "Pere", "initials": "P", "orcid": "0000-0002-3920-8576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5f47e2d780149d2b28dd7079b83858d.json"}}, {"family": "Miranda-Mendizabal", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3649-7509", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f0dbcee3855458bad3a28364ca06660.json"}}, {"family": "Recoder", "given": "Silvia", "initials": "S", "orcid": "0000-0001-9012-0951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2a5bf86399b4f9db4f65ed751dcba55.json"}}, {"family": "Calbo Sebastian", "given": "Ester", "initials": "E", "orcid": "0000-0001-7750-5347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3002f2d890964d378c40eb3ff608e5fc.json"}}, {"family": "Casajuana-Closas", "given": "Marc", "initials": "M", "orcid": "0000-0001-5653-996X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb15f80de6ee4c859881cf3be4302594.json"}}, {"family": "Leiva", "given": "David", "initials": "D", "orcid": "0000-0003-1314-2588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/130239894726413d964750770b59a970.json"}}, {"family": "Manolov", "given": "Rumen", "initials": "R", "orcid": "0000-0002-9387-1926", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2edbbf5db29d412b9d1201a5abbdedd8.json"}}, {"family": "Matilla-Santander", "given": "Nuria", "initials": "N", "orcid": "0000-0002-5249-102X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a546005ec44e4c1c8ba3bed29bffbb5d.json"}}, {"family": "Lloveras-Bernat", "given": "Isaac", "initials": "I"}, {"family": "Forero", "given": "Carlos G", "initials": "CG", "orcid": "0000-0002-5245-0076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4c978c5182343b880503a902be6b36a.json"}}], "type": "journal article", "published": "2023-03-20", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "13", "issue": "1", "pages": "4547", "issn-l": "2045-2322"}, "abstract": "The COVID-19 pandemic and the political and health measures have profoundly affected the health of our populations. However, very few studies have been published assessing its impact using a prospective cohort. The aim of this study is to describe the impact on physical and mental health due to the COVID-19 pandemic in the general population in Spain, and according to COVID-19 clinical status, during the first year of the pandemic. A longitudinal cohort study with two online surveys were performed on a representative sample of the adult Spanish population before (N = 2005, October/November 2019) and during the pandemic (N = 1357, November/December 2020). We assessed disability using the World Health Organisation Disability Assessment Schedule (WHODAS), major depressive episode (MDE) and suicidal thoughts and behaviours (STB), using an adapted version of the Composite International Diagnostic Interview (CIDI 3.0); generalised anxiety disorder (GAD) using the GAD-7 scale; post-traumatic stress disorder (PTSD) symptoms using the PTSD checklist for DSM-5 (PCL-5). For physical health, there was a statistically significant loss of weight (mean/SD) (T0, 73.22/15.56 vs. T1, 71.21/11.94), less use of tobacco (T0, 11.4% vs. T1, 9.0%) and decreased disability (mean/SD) (T0, 21.52/9.22 vs. T1, 19.03/7.32). For mental health, there was a significant increase in MDE (T0, 6.5% vs. T1, 8.8%) and in the prevalence of GAD (T0, 13.7% vs. T1, 17.7%). The prevalence of STB (T0, 15.1% vs. T1, 7.1%) significantly decreased. Individuals who declared they had been diagnosed with COVID-19 (3.6%) showed a worsening in physical health and an increase in mental health problems and PTSD symptoms. Although suicide risk during the first year of the pandemic was significantly less, many suicide risk factors increased: such as the incidence and persistence of MDE and GAD, the presence of PTSD symptoms in those diagnosed with COVID-19, and a worsening in self-assessed health status. We expect an increase in STB in the population in the long-term. Future research should gather information about the long-term impact of the pandemic.", "doi": "10.1038/s41598-023-28336-2", "pmid": "36941282", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10026238"}, {"db": "pii", "key": "10.1038/s41598-023-28336-2"}], "notes": [], "created": "2023-04-21T16:08:29.984Z", "modified": "2023-04-21T16:08:30.303Z"}, {"entity": "publication", "iuid": "06be7b4ac8c447758d200492540d935c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/06be7b4ac8c447758d200492540d935c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/06be7b4ac8c447758d200492540d935c"}}, "title": "Coping with COVID-19 Pandemic and Sustained Health Behavior: A Cross-Sectional Study in Bangladesh.", "authors": [{"family": "Sizear", "given": "Monaemul Islam", "initials": "MI"}, {"family": "Macassa", "given": "Gloria", "initials": "G", "orcid": "0000-0003-4415-7942", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90dedd73015141c287bc67122ace3764.json"}}, {"family": "Chowdhury", "given": "Mohammad Rocky Khan", "initials": "MRK"}, {"family": "Rashid", "given": "Mamunur", "initials": "M", "orcid": "0000-0001-7558-4168", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f94086e479574c90a4bd63fac5ce70ad.json"}}], "type": "journal article", "published": "2023-03-20", "journal": {"title": "Epidemiologia (Basel)", "issn": "2673-3986", "volume": "4", "issue": "1", "pages": "85-93", "issn-l": null}, "abstract": "During the COVID-19 pandemic, people's health behavioral changes have been transposed into a new dimension. Coping with the COVID-19 pandemic may have an impact on sustained health behavior (SHB). Therefore, this study aimed to explore the validity and reliability of the COVID-19 Coping Scale among working-age individuals and to assess whether coping with COVID-19-related stress could influence SHB in this population. A cross-sectional study was conducted based on the population of the city of Dhaka in Bangladesh. A total of 263 working-age individuals (19-65 years) participated in the study. The present study results confirmed the COVID-19 Coping Scale was a valid and reliable instrument for this population. Moreover, the present finding indicated decreased odds of SHB for individuals who rated lower scores on coping with COVID-19 compared to individuals who rated higher scores; the result remained significant after controlling for gender and education (OR 0.68, 95% CI: 0.54-0.87). The present study suggests two important findings: (i) the instrument used in this study was valid and reliable in this population, and (ii) coping with COVID-19-related stress may be an important aspect of practicing SHB. Policymakers may use the highlighted findings to facilitate sustainable health behavior for long-term health benefits and to tackle future pandemics like COVID-19 or in a similar context.", "doi": "10.3390/epidemiologia4010009", "pmid": "36975617", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10048345"}, {"db": "pii", "key": "epidemiologia4010009"}], "notes": [], "created": "2023-04-21T15:59:19.227Z", "modified": "2023-04-21T15:59:19.323Z"}, {"entity": "publication", "iuid": "ece960f599fd4e9a893444d788d8dbdc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ece960f599fd4e9a893444d788d8dbdc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ece960f599fd4e9a893444d788d8dbdc"}}, "title": "Computerization of the Work of General Practitioners: Mixed Methods Survey of Final-Year Medical Students in Ireland.", "authors": [{"family": "Blease", "given": "Charlotte", "initials": "C", "orcid": "0000-0003-3657-2476", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af05b93e66b34265808f33799070ef16.json"}}, {"family": "Kharko", "given": "Anna", "initials": "A", "orcid": "0000-0003-0908-6173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a367f676bc334b7fbdcae307d5e292a2.json"}}, {"family": "Bernstein", "given": "Michael", "initials": "M", "orcid": "0000-0001-7221-0697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe1a4546ab09474c97096de65036f69a.json"}}, {"family": "Bradley", "given": "Colin", "initials": "C", "orcid": "0000-0002-3595-9567", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61ed23f766504570b950289fc569f806.json"}}, {"family": "Houston", "given": "Muiris", "initials": "M", "orcid": "0000-0003-4124-8523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce99d9a5ea2c474bb6185c69ff21ffdc.json"}}, {"family": "Walsh", "given": "Ian", "initials": "I", "orcid": "0000-0002-3750-2499", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c81f5124483a41b5b4b87fb60875bba6.json"}}, {"family": "D Mandl", "given": "Kenneth", "initials": "K", "orcid": "0000-0002-9781-0477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4fb859839a7d46eb963d58e8fa0cab58.json"}}], "type": "journal article", "published": "2023-03-20", "journal": {"title": "JMIR Med Educ", "issn": "2369-3762", "volume": "9", "pages": "e42639", "issn-l": null}, "abstract": "The potential for digital health technologies, including machine learning (ML)-enabled tools, to disrupt the medical profession is the subject of ongoing debate within biomedical informatics.\n\nWe aimed to describe the opinions of final-year medical students in Ireland regarding the potential of future technology to replace or work alongside general practitioners (GPs) in performing key tasks.\n\nBetween March 2019 and April 2020, using a convenience sample, we conducted a mixed methods paper-based survey of final-year medical students. The survey was administered at 4 out of 7 medical schools in Ireland across each of the 4 provinces in the country. Quantitative data were analyzed using descriptive statistics and nonparametric tests. We used thematic content analysis to investigate free-text responses.\n\nIn total, 43.1% (252/585) of the final-year students at 3 medical schools responded, and data collection at 1 medical school was terminated due to disruptions associated with the COVID-19 pandemic. With regard to forecasting the potential impact of artificial intelligence (AI)/ML on primary care 25 years from now, around half (127/246, 51.6%) of all surveyed students believed the work of GPs will change minimally or not at all. Notably, students who did not intend to enter primary care predicted that AI/ML will have a great impact on the work of GPs.\n\nWe caution that without a firm curricular foundation on advances in AI/ML, students may rely on extreme perspectives involving self-preserving optimism biases that demote the impact of advances in technology on primary care on the one hand and technohype on the other. Ultimately, these biases may lead to negative consequences in health care. Improvements in medical education could help prepare tomorrow's doctors to optimize and lead the ethical and evidence-based implementation of AI/ML-enabled tools in medicine for enhancing the care of tomorrow's patients.", "doi": "10.2196/42639", "pmid": "36939809", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "v9i1e42639"}], "notes": [], "created": "2023-04-21T16:09:17.739Z", "modified": "2023-04-21T16:09:17.978Z"}, {"entity": "publication", "iuid": "c36f8f54506f4c818e2bf18f5a4a6a80", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c36f8f54506f4c818e2bf18f5a4a6a80.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c36f8f54506f4c818e2bf18f5a4a6a80"}}, "title": "Vulval Aphthous Ulcers in Adolescents Following COVID-19 Vaccination - Analysis of an international case series.", "authors": [{"family": "Rudolph", "given": "Annette", "initials": "A"}, {"family": "Savage", "given": "Dr Ruth", "initials": "DR"}], "type": "journal article", "published": "2023-03-17", "journal": {"title": "J Pediatr Adolesc Gynecol", "issn": "1873-4332", "issn-l": null}, "abstract": "To review and characterise reports of vulval aphthous ulcers (VAU) following COVID-19 vaccination in VigiBase, the World Health Organization global database of reported potential side effects of medicinal products, to demonstrate the importance and power of case reports for rare suspected adverse reactions and to investigate whether they suggest a potential for COVID-19 vaccination to be a trigger.\n\nCases reporting the Medical Dictionary for Regulatory Activities' (MedDRA) Preferred Term (PT) \"Vulvovaginal ulceration\" and related PTs in adolescent patients aged 12 to 17 years in association with any COVID-19 vaccine were extracted from VigiBase. The cases were clinically reviewed, and causality was assessed by applying the Bradford Hill criteria to the obtained case series.\n\nAs of June 30th, 2022, there were 444 reports for the selected MedDRA PTs following COVID-19 vaccination in VigiBase. Ninety-four de-duplicated reports concerned adolescent female patients. Thirty-seven cases were clinically consistent with the diagnosis of VAU. Upon causality assessment, the analysed case series fulfilled six of the nine Austen Bradford Hill criteria supporting a potential causal relationship.\n\nVAU can be perceived as a traumatic experience, especially in adolescent patients. There is, furthermore, a risk that the ulcers will be misdiagnosed resulting in avoidable investigation and treatment burdens for patients. We communicate our findings to support the small number of published case reports and raise awareness of VAU occurring in a temporal association with COVID-19 vaccination. Furthermore, our analysis supports observations about the value of case reports for the recognition and assessment of rare adverse events.", "doi": "10.1016/j.jpag.2023.03.006", "pmid": "36934803", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC10020135"}, {"db": "pii", "key": "S1083-3188(23)00311-X"}], "notes": [], "created": "2023-04-21T16:11:18.536Z", "modified": "2023-04-21T16:11:18.564Z"}, {"entity": "publication", "iuid": "1a0d84990b34405eabcad32112e03176", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1a0d84990b34405eabcad32112e03176.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1a0d84990b34405eabcad32112e03176"}}, "title": "Severe COVID-19 during pregnancy in Sweden, Norway, and Denmark.", "authors": [{"family": "\u00d6rtqvist", "given": "Anne K", "initials": "AK", "orcid": "0000-0001-9019-9233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7bfdbeb2a2d848ec928a6c7f7d112465.json"}}, {"family": "Magnus", "given": "Maria C", "initials": "MC", "orcid": "0000-0002-0568-3774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3530918cfd534021a45a80628c89c580.json"}}, {"family": "Aabakke", "given": "Anna J M", "initials": "AJM", "orcid": "0000-0003-4754-506X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c142bd2b1fc84a7e864d2af58096bcaf.json"}}, {"family": "Urhoj", "given": "Stine Kjaer", "initials": "SK", "orcid": "0000-0002-2069-9723", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b924cc03db2b4fffbb075e2d7e3579ac.json"}}, {"family": "Vinkel Hansen", "given": "Anne", "initials": "A", "orcid": "0000-0003-4523-3521", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7045d9cc7a814e718d962615eebe0a1a.json"}}, {"family": "Nybo Andersen", "given": "Anne-Marie", "initials": "AM"}, {"family": "Krebs", "given": "Lone", "initials": "L", "orcid": "0000-0001-5433-4776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1efab04a970448494fc2e06bfa3a55c.json"}}, {"family": "Pettersson", "given": "Karin", "initials": "K"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE", "orcid": "0000-0002-2199-5225", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eaa51eb1c42a4b12b21b248e363fbf04.json"}}, {"family": "Stephansson", "given": "Olof", "initials": "O", "orcid": "0000-0003-1528-4563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39af50356a574c80ba6bd2227ecb5cf5.json"}}], "type": "journal article", "published": "2023-03-17", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "issn-l": "0001-6349"}, "abstract": "Pregnancy is a risk factor for severe coronavirus disease 2019 (COVID-19) and adverse pregnancy outcomes. We aimed to explore maternal characteristics, pregnancy outcomes, vaccination status, and virus variants among pregnant women admitted to intensive care units (ICU) with severe COVID-19.\n\nWe identified pregnant women admitted to ICU in Sweden (n = 96), Norway (n = 31), and Denmark (n = 16) because of severe COVID-19, from national registers and clinical databases between March 2020 and February 2022 (Denmark), August 2022 (Sweden), or December 2022 (Norway). Their background characteristics, pregnancy outcome, and vaccination status were compared with all birthing women and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test-positive pregnant women during the same time period. We calculated the number admitted to ICU per 10 000 birthing and per 1000 SARS-CoV-2 test-positive women during the Index, Alpha, Delta, and Omicron periods.\n\nWomen admitted to ICU had a higher mean body mass index, were more often of non-Scandinavian origin, had on average lower education and income levels, had a higher proportion of chronic and pregnancy-related conditions, delivered preterm, had neonates with low Apgar scores, and had more infants admitted to neonatal care, compared with all birthing and test-positive pregnant women. Of those admitted to ICU, only 7% had been vaccinated before admission. Overall, the highest proportion of women admitted to ICU per birthing was during the Delta period (4.1 per 10 000 birthing women). In Norway, the highest proportion admitted to ICU per test-positive pregnant women was during the Delta period (17.8 per 1000 test-positive), whereas the highest proportion of admitted per test-positive in Sweden and Denmark was seen during the Index period (15.4 and 8.9 per 1000 test-positive, respectively).\n\nAdmission to ICU because of COVID-19 in pregnancy was a rare event in the Scandinavian countries, but women who were unvaccinated, of non-Scandinavian origin, and with lower socio-economic status were at higher risk of admission to ICU. In addition, women admitted to ICU for COVID-19 had higher risk of adverse pregnancy outcomes.", "doi": "10.1111/aogs.14552", "pmid": "36928990", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-21T16:12:18.383Z", "modified": "2023-04-21T16:12:18.648Z"}, {"entity": "publication", "iuid": "86b59b89448646ff8a5c908dc1d5c06d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86b59b89448646ff8a5c908dc1d5c06d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86b59b89448646ff8a5c908dc1d5c06d"}}, "title": "Correction: Study protocol for a randomized controlled trial evaluating the effectiveness of an internet-based self-help intervention to cope with psychological distress due to COVID-19 in the Italian general population: the RinasciMENTE project.", "authors": [{"family": "Bertuzzi", "given": "Vanessa", "initials": "V", "orcid": "0000-0002-8541-5357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7abc069e75034b0e96265c7d48fb95a2.json"}}, {"family": "Semonella", "given": "Michelle", "initials": "M"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Manzoni", "given": "Gian Mauro", "initials": "GM"}, {"family": "Castelnuovo", "given": "Gianluca", "initials": "G"}, {"family": "Molinari", "given": "Enrico", "initials": "E"}, {"family": "Pietrabissa", "given": "Giada", "initials": "G"}], "type": "published erratum", "published": "2023-03-17", "journal": {"title": "Trials", "issn": "1745-6215", "volume": "24", "issue": "1", "pages": "201", "issn-l": null}, "abstract": null, "doi": "10.1186/s13063-023-07217-z", "pmid": "36932452", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10022985"}, {"db": "pii", "key": "10.1186/s13063-023-07217-z"}], "notes": [], "created": "2023-04-21T16:12:08.811Z", "modified": "2023-04-21T16:12:08.820Z"}, {"entity": "publication", "iuid": "c2ec02b31430403383952bf3cb8e1445", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2ec02b31430403383952bf3cb8e1445.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2ec02b31430403383952bf3cb8e1445"}}, "title": "Life Satisfaction among Self-Employed People in Different Welfare Regimes during the COVID-19 Pandemic: Significance of Household Finances and Concerns about Work.", "authors": [{"family": "Nordenmark", "given": "Mikael", "initials": "M"}, {"family": "Landstad", "given": "Bodil J", "initials": "BJ", "orcid": "0000-0001-6558-3129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bdb9f75451d4f2b8c87a8f8a837a09d.json"}}, {"family": "Tjulin", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Vinberg", "given": "Stig", "initials": "S", "orcid": "0000-0002-5935-5688", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c63c4ca58d242d18741dba0b0af5afb.json"}}], "type": "journal article", "published": "2023-03-15", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "20", "issue": "6", "issn-l": null}, "abstract": "Most studies have shown that self-employed people have higher levels of life satisfaction than employed people due to high levels of job satisfaction, work flexibility, and job control. However, during the COVID-19 pandemic, many self-employed people experienced economic strain and worried about the situation of their employees and survival of the company. The aim of this study was to examine the level of life satisfaction among self-employed people during the COVID-19 pandemic in different welfare regimes. Analyses were mainly based on Eurofound's \"Living, Working and COVID-19\" online survey. Fieldwork took place between April and June 2020 in 27 EU countries. The results showed that there was a significantly lower level of life satisfaction among self-employed people than employed people during the pandemic. This was in contrast to analyses from approximately one year before the pandemic, which showed that life satisfaction was higher among self-employed people. The main reasons for this lower level of life satisfaction among the self-employed during the pandemic were worse household financial situation and more worries about their job. Analyses of life satisfaction among the self-employed in different welfare regimes indicated that self-employed people in the Nordic welfare state regime largely kept their relatively high level of life satisfaction during the pandemic, but this was not the case for self-employed people in other welfare regimes.", "doi": "10.3390/ijerph20065141", "pmid": "36982050", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10049569"}, {"db": "pii", "key": "ijerph20065141"}], "notes": [], "created": "2023-04-21T15:57:00.390Z", "modified": "2023-04-21T15:57:50.063Z"}, {"entity": "publication", "iuid": "2b48e1851208422999e1cae7b9e92800", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b48e1851208422999e1cae7b9e92800.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b48e1851208422999e1cae7b9e92800"}}, "title": "COVID-19 and income inequality: evidence from monthly population registers.", "authors": [{"family": "Angelov", "given": "Nikolay", "initials": "N"}, {"family": "Waldenstr\u00f6m", "given": "Daniel", "initials": "D", "orcid": "0000-0002-0940-2466", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1941a15d28f44dc8f42615088795534.json"}}], "type": "journal article", "published": "2023-03-15", "journal": {"title": "J Econ Inequal", "issn": "1569-1721", "issn-l": null, "volume": null, "issue": null, "pages": "1-29"}, "abstract": "We measure the distributional impact of the COVID-19 pandemic using newly released population register data in Sweden. Monthly earnings inequality increased during the pandemic, and the key driver is income losses among low-paid individuals while middle- and high-income earners were almost unaffected. In terms of employment, as measured by having positive monthly earnings, the pandemic had a larger negative impact on private-sector workers and on women. In terms of earnings conditional on being employed, the effect was still more negative for women, but less negative for private-sector workers compared to publicly employed. Using data on individual take-up of government COVID-19 support, we show that policy significantly dampened the inequality increase, but did not fully offset it. Annual total market income inequality, which also includes capital income and taxable transfers, shows similar patterns of increasing inequality during the pandemic.\r\n\r\nThe online version contains supplementary material available at 10.1007/s10888-022-09560-8.", "doi": "10.1007/s10888-022-09560-8", "pmid": "37360569", "labels": {"Category: Public Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10015130"}, {"db": "pii", "key": "9560"}], "notes": [], "created": "2023-10-04T09:31:51.035Z", "modified": "2023-10-04T10:56:21.962Z"}, {"entity": "publication", "iuid": "87617a1379e04fb7aa3b32595d1bc9d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87617a1379e04fb7aa3b32595d1bc9d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87617a1379e04fb7aa3b32595d1bc9d9"}}, "title": "Recruitment of Adolescent Young Carers to a Psychosocial Support Intervention Study in Six European Countries: Lessons Learned from the ME-WE Project.", "authors": [{"family": "Barbabella", "given": "Francesco", "initials": "F"}, {"family": "Magnusson", "given": "Lennart", "initials": "L"}, {"family": "Boccaletti", "given": "Licia", "initials": "L"}, {"family": "Casu", "given": "Giulia", "initials": "G", "orcid": "0000-0001-5441-3044", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7cd6e9e8122e40fb8aa1fd15dff39c9f.json"}}, {"family": "Hlebec", "given": "Valentina", "initials": "V"}, {"family": "Bolko", "given": "Irena", "initials": "I"}, {"family": "Lewis", "given": "Feylyn", "initials": "F", "orcid": "0000-0003-2306-8182", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35b1b33cf19e44a895362c21b4184b08.json"}}, {"family": "Hoefman", "given": "Renske", "initials": "R", "orcid": "0000-0003-4533-2562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/979bca9baba2402e8c03397c113d9bd2.json"}}, {"family": "Brolin", "given": "Rosita", "initials": "R"}, {"family": "Santini", "given": "Sara", "initials": "S", "orcid": "0000-0003-4705-4631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0b2248297e14350917aa7ec610d87f4.json"}}, {"family": "Socci", "given": "Marco", "initials": "M", "orcid": "0000-0001-9093-2167", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff1725877f3344b9bfa11c4fafa40e9d.json"}}, {"family": "D'Amen", "given": "Barbara", "initials": "B", "orcid": "0000-0002-8986-5216", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ccb20d6201a47d887799947d62154b3.json"}}, {"family": "de Jong", "given": "Yvonne", "initials": "Y"}, {"family": "Bouwman", "given": "Tamara", "initials": "T"}, {"family": "de Jong", "given": "Nynke", "initials": "N"}, {"family": "Leu", "given": "Agnes", "initials": "A", "orcid": "0000-0002-5451-837X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e084dede367e4310bdfd006ad84499eb.json"}}, {"family": "Phelps", "given": "Daniel", "initials": "D"}, {"family": "Guggiari", "given": "Elena", "initials": "E", "orcid": "0000-0002-8656-9825", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc16e1d387114fc482d40dd5be7e89d9.json"}}, {"family": "Wirth", "given": "Alexandra", "initials": "A"}, {"family": "Morgan", "given": "Vicky", "initials": "V"}, {"family": "Becker", "given": "Saul", "initials": "S"}, {"family": "Hanson", "given": "Elizabeth", "initials": "E", "orcid": "0000-0001-7609-4822", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1652497e6384360bc8c55d2670be4a9.json"}}], "type": "randomized controlled trial", "published": "2023-03-14", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "20", "issue": "6", "issn-l": null}, "abstract": "Young carers provide a substantial amount of care to family members and support to friends, yet their situation has not been actively addressed in research and policy in many European countries or indeed globally. Awareness of their situation by professionals and among children and young carers themselves remains low overall. Thus, young carers remain a largely hidden group within society. This study reports and analyses the recruitment process in a multi-centre intervention study offering psychosocial support to adolescent young carers (AYCs) aged 15-17 years. A cluster-randomised controlled trial was designed, with recruitment taking place in Italy, the Netherlands, Slovenia, Sweden, Switzerland and the United Kingdom exploiting various channels, including partnerships with schools, health and social services and carers organisations. In total, 478 AYCs were recruited and, after screening failures, withdrawals and initial dropouts, 217 were enrolled and started the intervention. Challenges encountered in reaching, recruiting and retaining AYCs included low levels of awareness among AYCs, a low willingness to participate in study activities, uncertainty about the prevalence of AYCs, a limited school capacity to support the recruitment; COVID-19 spreading in 2020-2021 and related restrictions. Based on this experience, recommendations are put forward for how to better engage AYCs in research.", "doi": "10.3390/ijerph20065074", "pmid": "36981983", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10049644"}, {"db": "pii", "key": "ijerph20065074"}], "notes": [], "created": "2023-04-21T15:58:06.553Z", "modified": "2023-04-21T15:58:06.801Z"}, {"entity": "publication", "iuid": "39efdd3d431f44b8bea54043da5f5f6d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/39efdd3d431f44b8bea54043da5f5f6d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/39efdd3d431f44b8bea54043da5f5f6d"}}, "title": "The COVID-19 endemic in Vietnam: Contextual considerations and implications.", "authors": [{"family": "Doan", "given": "Linh Phuong", "initials": "LP"}, {"family": "Le Vu", "given": "Minh Ngoc", "initials": "MN"}, {"family": "Vu", "given": "Giang Thu", "initials": "GT"}, {"family": "Le", "given": "Huong Thi", "initials": "HT"}, {"family": "Nguyen", "given": "Long Hoang", "initials": "LH"}, {"family": "Latkin", "given": "Carl A", "initials": "CA"}, {"family": "Ho", "given": "Roger C M", "initials": "RCM"}], "type": "journal article", "published": "2023-03-13", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "11", "pages": "997635", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2023.997635", "pmid": "36992873", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10040746"}], "notes": [], "created": "2023-04-21T15:55:27.197Z", "modified": "2023-04-21T15:55:27.201Z"}, {"entity": "publication", "iuid": "10e18b6f1cc6468784325fed2801dbcf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/10e18b6f1cc6468784325fed2801dbcf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/10e18b6f1cc6468784325fed2801dbcf"}}, "title": "NK cells in COVID-19 - from disease to vaccination.", "authors": [{"family": "Hammer", "given": "Quirin", "initials": "Q"}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Bister", "given": "Jonna", "initials": "J"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4691d38f3268433696d7c65ea235a12b.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}], "type": "journal article", "published": "2023-03-11", "journal": {"title": "J Leukoc Biol", "issn": "1938-3673", "issn-l": null}, "abstract": "Natural killer (NK) cells participate in the host innate immune response to viral infection. Conversely, NK cell dysfunction and hyperactivation can contribute to tissue damage and immunopathology. Here, we review recent studies with respect to NK cell activity during infection with human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Discussed are initial reports of patients hospitalized with coronavirus disease 2019 (COVID-19), which revealed prompt NK cell activation during the acute disease state. Another hallmark of COVID-19, early on observed, was a decrease in numbers of NK cells in the circulation. Data from patients with acute SARS-CoV-2 infection as well as from in vitro models demonstrated strong anti-SARS-CoV-2 activity by NK cells, likely through direct cytotoxicity as well as indirectly by secreting cytokines. Additionally, we describe the molecular mechanisms underlying NK cell recognition of SARS-CoV-2 infected cells, which involve triggering of multiple activating receptors including NKG2D as well as loss-of-inhibition through NKG2A. Discussed is also the ability of NK cells to respond to SARS-CoV-2 infection via antibody dependent cellular cytotoxicity. With the respect to NK cells in the pathogenesis of COVID-19, we review studies demonstrating how hyperactivation and misdirected NK cell responses could contribute to disease course. Finally, while knowledge is still rather limited, we discuss current insights suggesting a contribution of an early NK cell activation-response in the generation of immunity against SARS-CoV-2 following vaccination an anti-SARS-CoV-2 mRNA vaccines.", "doi": "10.1093/jleuko/qiad031", "pmid": "36976012", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "7076154"}], "notes": [], "created": "2023-04-21T15:59:08.245Z", "modified": "2023-04-21T15:59:08.257Z"}, {"entity": "publication", "iuid": "01c42b267cba4509987e4de5e9f89818", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01c42b267cba4509987e4de5e9f89818.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01c42b267cba4509987e4de5e9f89818"}}, "title": "COVID-19 and unfavorable changes in mental health unrelated to changes in physical activity, sedentary time, and health behaviors among Swedish adolescents: A longitudinal study.", "authors": [{"family": "Nyberg", "given": "Gisela", "initials": "G"}, {"family": "Helgad\u00f3ttir", "given": "Bj\u00f6rg", "initials": "B"}, {"family": "Kjellenberg", "given": "Karin", "initials": "K"}, {"family": "Ekblom", "given": "\u00d6rjan", "initials": "\u00d6"}], "type": "journal article", "published": "2023-03-10", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "11", "pages": "1115789", "issn-l": "2296-2565"}, "abstract": "The COVID-19 pandemic has had major impact on the daily lives of adolescents. This study examined whether mental health outcomes had changed over the pandemic, and if such changes were related to changes in physical activity (PA), sedentary time, sleep, screen time, and participation in organized sports.\n\nIn this longitudinal study, data were collected in autumn 2019 with follow-up measurements in spring 2021. In total, 558 schools were invited and 34 schools around Stockholm with a variation in socioeconomic background were included. Physical activity and sedentary time were measured for seven consecutive days by accelerometry (Actigraph). Anxiety, health-related quality of life (HRQoL), psychosomatic health, stress, sleep duration, screen time, and organized sports participation were self-reported in questionnaires. Linear models were applied to estimate associations between changes in mental health outcomes and exposures.\n\nFrom the baseline sample of 1,139 participants, 585 (55% girls), mean (SD) age 14.9 (0.3) years, participated in the follow-up. Between 2019 and 2021, there was a decrease in HRQoL [mean difference -1.7 (-2.3, -1.2), p < 0.001], increase in psychosomatic health problems [mean difference 1.8 (1.3, 2.3), p < 0.001], and an increase in the number of participants with high stress [from 94 (28%) to 139 (42%), p < 0.001]. Weekly light PA and sleep duration decreased and weekly sedentary time and screen time increased unrelated to changes in mental health outcomes. An increase in sleep duration during weekdays was significantly related to both a decrease in anxiety (B = -0.71, CI: -1.36, -0.06) and an increase in HRQoL (B = 1.00, CI: 0.51, 1.49).\n\nDuring the COVID-19 pandemic, mental health appears to have been impaired in Swedish adolescents, but unrelated to changes in PA, sedentary time, screen time, or participation in organized sports. However, increased sleep duration on weekdays was related to less anxiety and better HRQoL. The results may help policy makers and other stakeholders comprehend the differential effects of the COVID-19 pandemic on mental health outcomes and help guiding the planning of policy actions.\n\nISRCTN15689873.", "doi": "10.3389/fpubh.2023.1115789", "pmid": "36969680", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10036362"}, {"db": "ISRCTN", "key": "ISRCTN15689873"}], "notes": [], "created": "2023-04-21T16:02:18.488Z", "modified": "2023-04-21T16:02:18.493Z"}, {"entity": "publication", "iuid": "fd9ca1a78b3a4cc8aefa609060b3984a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fd9ca1a78b3a4cc8aefa609060b3984a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fd9ca1a78b3a4cc8aefa609060b3984a"}}, "title": "Living through a Global Pandemic: A Cross-Sectional Study on the Psychological Resilience of the University Population in Iran.", "authors": [{"family": "Ahmadi", "given": "Fereshteh", "initials": "F", "orcid": "0000-0002-8823-6434", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f4f676633f24637b135c494dcb33cc9.json"}}, {"family": "Cetrez", "given": "\u00d6nver Andreas", "initials": "\u00d6A", "orcid": "0000-0001-6274-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3070dcb6e8234c9b973573f7172e7821.json"}}, {"family": "Zandi", "given": "Saeid", "initials": "S", "orcid": "0000-0003-1272-7170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a941295613dc468e8282c9f8f157a4b6.json"}}], "type": "journal article", "published": "2023-03-09", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "20", "issue": "6", "issn-l": null}, "abstract": "This study aimed to describe and understand the individual and social dimensions of resiliency among Iranian academics as professionals during the early wave of the ongoing pandemic. Furthermore, we aimed to emphasize the cultural context in our analysis.\n\nA cross-sectional survey design was adopted. We used convenient sampling, administered through an online survey, among academics at Iranian universities (n = 196, 75% women). We employed the CD-RISC 2 instrument, items on life meaning, and a modified version of Pargament's RCOPE instrument (Meaning, Control, Comfort/Spirituality, Intimacy/Spirituality, and Life Transformation).\n\nThe results revealed a strong level of resilience among men (M = 5.78) and women (M = 5.52). Self-rated health was rated as excellent, very good, or good among a majority (92%) of the participants, more so among men. Family was one of the factors that most strongly gave life meaning, followed by friends, work/school, and religion/spirituality. There was a strong correlation between self-rated health and life as part of a greater whole, being alone, and listening to the sounds of the surrounding nature.\n\nBoth personal and social levels of resilience and meaning-making are seen in the results, with an ability to balance between obstacles and resources. Cultural practices are interdependent, which also include the individual and social dimensions of resiliency and meaning-making.", "doi": "10.3390/ijerph20064844", "pmid": "36981752", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10049328"}, {"db": "pii", "key": "ijerph20064844"}], "notes": [], "created": "2023-04-21T15:58:20.899Z", "modified": "2023-04-21T15:58:20.975Z"}, {"entity": "publication", "iuid": "634c2fd0451c41c980c396b1199b3036", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/634c2fd0451c41c980c396b1199b3036.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/634c2fd0451c41c980c396b1199b3036"}}, "title": "Editorial: Medication safety in COVID-19 management, Volume II.", "authors": [{"family": "Das", "given": "Saibal", "initials": "S"}], "type": "editorial", "published": "2023-03-09", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "14", "pages": "1175152", "issn-l": "1663-9812"}, "abstract": null, "doi": "10.3389/fphar.2023.1175152", "pmid": "36969864", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10034399"}, {"db": "pii", "key": "1175152"}], "notes": [], "created": "2023-04-21T16:01:34.408Z", "modified": "2023-04-21T16:01:42.674Z"}, {"entity": "publication", "iuid": "8a242d597bec44148573ceb5c9f65abf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a242d597bec44148573ceb5c9f65abf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a242d597bec44148573ceb5c9f65abf"}}, "title": "\"Having vaccines is good but not enough\": Requirements for optimal COVID-19 immunization program in Vietnam.", "authors": [{"family": "Doan", "given": "Linh Phuong", "initials": "LP"}, {"family": "Dao", "given": "Nam Gia", "initials": "NG"}, {"family": "Nguyen", "given": "Duy Cao", "initials": "DC"}, {"family": "Dang", "given": "Trang Huyen Thi", "initials": "THT"}, {"family": "Vu", "given": "Giang Thu", "initials": "GT"}, {"family": "Nguyen", "given": "Long Hoang", "initials": "LH"}, {"family": "Vu", "given": "Linh Gia", "initials": "LG"}, {"family": "Le", "given": "Huong Thi", "initials": "HT"}, {"family": "Latkin", "given": "Carl A", "initials": "CA"}, {"family": "Ho", "given": "Cyrus S H", "initials": "CSH"}, {"family": "Ho", "given": "Roger C M", "initials": "RCM"}], "type": "journal article", "published": "2023-03-09", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "11", "pages": "1137401", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2023.1137401", "pmid": "36969663", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10033707"}], "notes": [], "created": "2023-04-21T16:02:31.008Z", "modified": "2023-04-21T16:02:31.022Z"}, {"entity": "publication", "iuid": "5abea92c910c4db68a4228c66e465a01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5abea92c910c4db68a4228c66e465a01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5abea92c910c4db68a4228c66e465a01"}}, "title": "Understanding the impact of the COVID\u201119 pandemic on healthcare services for adults during three waves of COVID\u201119 infections: A South African private sector experience.", "authors": [{"family": "Nematswerani", "given": "N", "initials": "N"}, {"family": "Steenkamp", "given": "L", "initials": "L"}, {"family": "Haneef", "given": "S", "initials": "S"}, {"family": "Naidoo", "given": "R M", "initials": "RM"}, {"family": "Fonn", "given": "S", "initials": "S"}], "type": "journal article", "published": "2023-03-08", "journal": {"title": "S Afr Med J", "issn": "2078-5135", "issn-l": null, "volume": "113", "issue": "4", "pages": "e16505"}, "abstract": "Since the onset of the COVID\u201119 pandemic, healthcare resources have been repurposed to focus on COVID\u201119. Resource reallocation and restrictions to movement that affected general access to care may have inadvertently resulted in undue disruptions in the continuum of care for patients requiring non-COVID\u201119 healthcare services.\r\n\r\nTo describe the change in pattern of health service use in the South African (SA) private sector.\r\n\r\nWe conducted a retrospective study of a nationwide cohort of privately insured individuals. An analysis of claims data was performed for non-COVID\u201119 related healthcare services provided from April 2020 to December 2020 (year 1 of COVID\u201119) and April 2021 to December 2021 (year 2 of COVID\u201119) relative to the same period in 2019 prior to the COVID\u201119 pandemic in SA. Over and above plotting the monthly trends, we tested for statistical significance of the changes using a Wilcoxon test given the non-normality of all the outcomes.\r\n\r\nBetween April and December 2020, relative to the same period in 2021, and also relative to the same period in 2019, we found a 31.9% (p<0.01) and a 16.6% (p<0.01) reduction in emergency room visits, respectively; a 35.9% (p<0.01) and 20.5% (p<0.01) reduction in medical hospital admissions; a 27.4% (p=0.01) and 13.0% (p=0.03) reduction in surgical hospital admissions; a 14.5% (p<0.01) and 4.1% (p=0.16) reduction in face-to-face general practitioner consultations for chronic members; a 24.9% (p=0.06) and 5.2% (p=0.54) reduction in mammography for female members; a 23.4% (p=0.03) and 10.8% (p=0.09) reduction in Pap smear screenings for female members; a 16.5% (p=0.08) and 12.1% (p=0.27) reduction in colorectal cancer registrations and an 18.2% (p=0.08) and 8.9% (p=0.07) decrease in all oncology diagnoses. Uptake of telehealth services throughout the healthcare delivery system increased by 5 708% in 2020 compared with 2019, and 36.1% for 2021 compared with 2020.\r\n\r\nA significant reduction in emergency room visits, hospital admissions and utilisation of primary care services was observed since the start of the pandemic. Further research is required to understand if there are long-term consequences of delayed care. An increase in the use of digital consultations was observed. Research on their acceptability and effectiveness may open new modalities of care, which may have cost- and time-saving benefits.", "doi": "10.7196/SAMJ.2023.v113i4.16505", "pmid": "37283155", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:31:48.559Z", "modified": "2023-10-04T10:55:10.601Z"}, {"entity": "publication", "iuid": "b181239c838c4757a71db6e6435ea230", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b181239c838c4757a71db6e6435ea230.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b181239c838c4757a71db6e6435ea230"}}, "title": "Improved outcomes over time and higher mortality in CMV seropositive allogeneic stem cell transplantation patients with COVID-19; An infectious disease working party study from the European Society for Blood and Marrow Transplantation registry.", "authors": [{"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Tridello", "given": "Gloria", "initials": "G"}, {"family": "Pi\u00f1ana", "given": "Jose Luis", "initials": "JL"}, {"family": "Ciceri", "given": "Fabio", "initials": "F"}, {"family": "Sengeloev", "given": "Henrik", "initials": "H"}, {"family": "Kulagin", "given": "Alexander", "initials": "A"}, {"family": "Mielke", "given": "Stephan", "initials": "S"}, {"family": "Yegin", "given": "Zeynep Arzu", "initials": "ZA"}, {"family": "Collin", "given": "Matthew", "initials": "M"}, {"family": "Einardottir", "given": "Sigrun", "initials": "S"}, {"family": "Lepretre", "given": "Sophie Ducastelle", "initials": "SD"}, {"family": "Maertens", "given": "Johan", "initials": "J"}, {"family": "Campos", "given": "Antonio", "initials": "A"}, {"family": "Metafuni", "given": "Elisabetta", "initials": "E"}, {"family": "Pichler", "given": "Herbert", "initials": "H"}, {"family": "Folber", "given": "Frantisek", "initials": "F"}, {"family": "Solano", "given": "Carlos", "initials": "C"}, {"family": "Nicholson", "given": "Emma", "initials": "E"}, {"family": "Y\u00fcksel", "given": "Meltem Kurt", "initials": "MK"}, {"family": "Carlson", "given": "Kristina", "initials": "K"}, {"family": "Aguado", "given": "Beatriz", "initials": "B"}, {"family": "Besley", "given": "Caroline", "initials": "C"}, {"family": "Byrne", "given": "Jenny", "initials": "J"}, {"family": "Heras", "given": "Immaculada", "initials": "I"}, {"family": "Dignan", "given": "Fiona", "initials": "F"}, {"family": "Kr\u00f6ger", "given": "Nicolaus", "initials": "N"}, {"family": "Robin", "given": "Christine", "initials": "C"}, {"family": "Khan", "given": "Anjum", "initials": "A"}, {"family": "Lenhoff", "given": "Stig", "initials": "S"}, {"family": "Grassi", "given": "Anna", "initials": "A"}, {"family": "Dobsinska", "given": "Veronika", "initials": "V"}, {"family": "Miranda", "given": "Nuno", "initials": "N"}, {"family": "Jimenez", "given": "Maria-Jose", "initials": "MJ"}, {"family": "Yonal-Hindilerden", "given": "Ipek", "initials": "I"}, {"family": "Wilson", "given": "Keith", "initials": "K"}, {"family": "Averbuch", "given": "Dina", "initials": "D"}, {"family": "Cesaro", "given": "Simone", "initials": "S"}, {"family": "Xhaard", "given": "Alienor", "initials": "A"}, {"family": "Knelange", "given": "Nina", "initials": "N"}, {"family": "Styczynski", "given": "Jan", "initials": "J"}, {"family": "Mikulska", "given": "Malgorzata", "initials": "M"}, {"family": "de la Camara", "given": "Rafael", "initials": "R"}], "type": "journal article", "published": "2023-03-07", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "14", "pages": "1125824", "issn-l": "1664-3224"}, "abstract": "COVID-19 has been associated with high morbidity and mortality in allogeneic hematopoietic stem cell transplant (allo-HCT) recipients.\n\nThis study reports on 986 patients reported to the EBMT registry during the first 29 months of the pandemic.\n\nThe median age was 50.3 years (min - max; 1.0 - 80.7). The median time from most recent HCT to diagnosis of COVID-19 was 20 months (min - max; 0.0 - 383.9). The median time was 19.3 (0.0 - 287.6) months during 2020, 21.2 (0.1 - 324.5) months during 2021, and 19.7 (0.1 - 383.9) months during 2022 (p = NS). 145/986 (14.7%) patients died; 124 (12.6%) due to COVID-19 and 21 of other causes. Only 2/204 (1%) fully vaccinated patients died from COVID-19. There was a successive improvement in overall survival over time. In multivariate analysis, increasing age (p<.0001), worse performance status (p<.0001), contracting COVID-19 within the first 30 days (p<.0001) or 30 - 100 days after HCT (p=.003), ongoing immunosuppression (p=.004), pre-existing lung disease (p=.003), and recipient CMV seropositivity (p=.004) had negative impact on overall survival while patients contracting COVID-19 in 2020 (p<.0001) or 2021 (p=.027) had worse overall survival than patients with COVID-19 diagnosed in 2022.\n\nAlthough the outcome of COVID-19 has improved, patients having risk factors were still at risk for severe COVID-19 including death.", "doi": "10.3389/fimmu.2023.1125824", "pmid": "36960069", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10028143"}], "notes": [], "created": "2023-04-21T16:04:40.764Z", "modified": "2023-04-21T16:04:40.779Z"}, {"entity": "publication", "iuid": "65f05be676d24d99a94289740229f478", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65f05be676d24d99a94289740229f478.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65f05be676d24d99a94289740229f478"}}, "title": "Dissection of Antibody Responses of Gam-COVID-Vac-Vaccinated Subjects Suggests Involvement of Epitopes Outside RBD in SARS-CoV-2 Neutralization.", "authors": [{"family": "Byazrova", "given": "Maria", "initials": "M"}, {"family": "Gattinger", "given": "Pia", "initials": "P", "orcid": "0000-0001-6724-8543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d470813c45d04ab295b0df1b02d7cf93.json"}}, {"family": "Astakhova", "given": "Ekaterina", "initials": "E"}, {"family": "Hofer", "given": "Gerhard", "initials": "G"}, {"family": "Khaitov", "given": "Musa", "initials": "M"}, {"family": "Filatov", "given": "Alexander", "initials": "A", "orcid": "0000-0002-6460-9427", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68803e957803458d89d969484dc7420b.json"}}, {"family": "Valenta", "given": "Rudolf", "initials": "R"}], "type": "journal article", "published": "2023-03-07", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "24", "issue": "6", "issn-l": null}, "abstract": "Millions of people have been vaccinated with Gam-COVID-Vac but fine specificities of induced antibodies have not been fully studied. Plasma from 12 na\u00efve and 10 coronavirus disease 2019 (COVID-19) convalescent subjects was obtained before and after two immunizations with Gam-COVID-Vac. Antibody reactivity in the plasma samples (n = 44) was studied on a panel of micro-arrayed recombinant folded and unfolded severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins and 46 peptides spanning the spike protein (S) and by immunoglobulin G (IgG) subclass enzyme-linked immunosorbent assay (ELISA). The ability of Gam-COVID-Vac-induced antibodies to inhibit binding of the receptor-binding domain (RBD) to its receptor angiotensin converting enzyme 2 (ACE2) was investigated in a molecular interaction assay (MIA). The virus-neutralizing capacity of antibodies was studied by the pseudo-typed virus neutralization test (pVNT) for Wuhan-Hu-1 and Omicron. We found that Gam-COVID-Vac vaccination induced significant increases of IgG1 but not of other IgG subclasses against folded S, spike protein subunit 1 (S1), spike protein subunit 2 (S2), and RBD in a comparable manner in na\u00efve and convalescent subjects. Virus neutralization was highly correlated with vaccination-induced antibodies specific for folded RBD and a novel peptide (i.e., peptide 12). Peptide 12 was located close to RBD in the N-terminal part of S1 and may potentially be involved in the transition of the pre- to post-fusion conformation of the spike protein. In summary, Gam-COVID-Vac vaccination induced S-specific IgG1 antibodies in naive and convalescent subjects in a comparable manner. Besides the antibodies specific for RBD, the antibodies induced against a peptide close to the N-terminus of RBD were also associated with virus-neutralization.", "doi": "10.3390/ijms24065104", "pmid": "36982183", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC10049224"}, {"db": "pii", "key": "ijms24065104"}], "notes": [], "created": "2023-04-21T15:56:40.490Z", "modified": "2023-04-21T15:56:40.549Z"}, {"entity": "publication", "iuid": "2b3b7fc6d3ce4e78967d2aa8eb20b4ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b3b7fc6d3ce4e78967d2aa8eb20b4ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b3b7fc6d3ce4e78967d2aa8eb20b4ae"}}, "title": "Management of patients with advanced prostate cancer-metastatic and/or castration-resistant prostate cancer: report of the Advanced Prostate Cancer Consensus Conference (APCCC) 2022.", "authors": [{"family": "Gillessen", "given": "Silke", "initials": "S"}, {"family": "Bossi", "given": "Alberto", "initials": "A"}, {"family": "Davis", "given": "Ian D", "initials": "ID"}, {"family": "de Bono", "given": "Johann", "initials": "J"}, {"family": "Fizazi", "given": "Karim", "initials": "K"}, {"family": "James", "given": "Nicholas D", "initials": "ND"}, {"family": "Mottet", "given": "Nicolas", "initials": "N"}, {"family": "Shore", "given": "Neal", "initials": "N"}, {"family": "Small", "given": "Eric", "initials": "E"}, {"family": "Smith", "given": "Matthew", "initials": "M"}, {"family": "Sweeney", "given": "Christopher J", "initials": "CJ"}, {"family": "Tombal", "given": "Bertrand", "initials": "B"}, {"family": "Antonarakis", "given": "Emmanuel S", "initials": "ES"}, {"family": "Aparicio", "given": "Ana M", "initials": "AM"}, {"family": "Armstrong", "given": "Andrew J", "initials": "AJ"}, {"family": "Attard", "given": "Gerhardt", "initials": "G"}, {"family": "Beer", "given": "Tomasz M", "initials": "TM"}, {"family": "Beltran", "given": "Himisha", "initials": "H"}, {"family": "Bjartell", "given": "Anders", "initials": "A"}, {"family": "Blanchard", "given": "Pierre", "initials": "P"}, {"family": "Briganti", "given": "Alberto", "initials": "A"}, {"family": "Bristow", "given": "Rob G", "initials": "RG"}, {"family": "Bulbul", "given": "Muhammad", "initials": "M"}, {"family": "Caffo", "given": "Orazio", "initials": "O"}, {"family": "Castellano", "given": "Daniel", "initials": "D"}, {"family": "Castro", "given": "Elena", "initials": "E"}, {"family": "Cheng", "given": "Heather H", "initials": "HH"}, {"family": "Chi", "given": "Kim N", "initials": "KN"}, {"family": "Chowdhury", "given": "Simon", "initials": "S"}, {"family": "Clarke", "given": "Caroline S", "initials": "CS"}, {"family": "Clarke", "given": "Noel", "initials": "N"}, {"family": "Daugaard", "given": "Gedske", "initials": "G"}, {"family": "De Santis", "given": "Maria", "initials": "M"}, {"family": "Duran", "given": "Ignacio", "initials": "I"}, {"family": "Eeles", "given": "Ross", "initials": "R"}, {"family": "Efstathiou", "given": "Eleni", "initials": "E"}, {"family": "Efstathiou", "given": "Jason", "initials": "J"}, {"family": "Ekeke", "given": "Onyeanunam Ngozi", "initials": "ON"}, {"family": "Evans", "given": "Christopher P", "initials": "CP"}, {"family": "Fanti", "given": "Stefano", "initials": "S"}, {"family": "Feng", "given": "Felix Y", "initials": "FY"}, {"family": "Fonteyne", "given": "Valerie", "initials": "V"}, {"family": "Fossati", "given": "Nicola", "initials": "N"}, {"family": "Frydenberg", "given": "Mark", "initials": "M"}, {"family": "George", "given": "Dan", "initials": "D"}, {"family": "Gleave", "given": "Martin", "initials": "M"}, {"family": "Gravis", "given": "Gwenaelle", "initials": "G"}, {"family": "Halabi", "given": "Susan", "initials": "S"}, {"family": "Heinrich", "given": "Daniel", "initials": "D"}, {"family": "Herrmann", "given": "Ken", "initials": "K"}, {"family": "Higano", "given": "Celestia", "initials": "C"}, {"family": "Hofman", "given": "Michael S", "initials": "MS"}, {"family": "Horvath", "given": "Lisa G", "initials": "LG"}, {"family": "Hussain", "given": "Maha", "initials": "M"}, {"family": "Jereczek-Fossa", "given": "Barbara A", "initials": "BA"}, {"family": "Jones", "given": "Rob", "initials": "R"}, {"family": "Kanesvaran", "given": "Ravindran", "initials": "R"}, {"family": "Kellokumpu-Lehtinen", "given": "Pirkko-Liisa", "initials": "PL"}, {"family": "Khauli", "given": "Raja B", "initials": "RB"}, {"family": "Klotz", "given": "Laurence", "initials": "L"}, {"family": "Kramer", "given": "Gero", "initials": "G"}, {"family": "Leibowitz", "given": "Raja", "initials": "R"}, {"family": "Logothetis", "given": "Christopher", "initials": "C"}, {"family": "Mahal", "given": "Brandon", "initials": "B"}, {"family": "Maluf", "given": "Fernando", "initials": "F"}, {"family": "Mateo", "given": "Joaquin", "initials": "J"}, {"family": "Matheson", "given": "David", "initials": "D"}, {"family": "Mehra", "given": "Niven", "initials": "N"}, {"family": "Merseburger", "given": "Axel", "initials": "A"}, {"family": "Morgans", "given": "Alicia K", "initials": "AK"}, {"family": "Morris", "given": "Michael J", "initials": "MJ"}, {"family": "Mrabti", "given": "Hind", "initials": "H"}, {"family": "Mukherji", "given": "Deborah", "initials": "D"}, {"family": "Murphy", "given": "Declan G", "initials": "DG"}, {"family": "Murthy", "given": "Vedang", "initials": "V"}, {"family": "Nguyen", "given": "Paul L", "initials": "PL"}, {"family": "Oh", "given": "William K", "initials": "WK"}, {"family": "Ost", "given": "Piet", "initials": "P"}, {"family": "O'Sullivan", "given": "Joe M", "initials": "JM"}, {"family": "Padhani", "given": "Anwar R", "initials": "AR"}, {"family": "Pezaro", "given": "Carmel J", "initials": "CJ"}, {"family": "Poon", "given": "Darren M C", "initials": "DMC"}, {"family": "Pritchard", "given": "Colin C", "initials": "CC"}, {"family": "Rabah", "given": "Danny M", "initials": "DM"}, {"family": "Rathkopf", "given": "Dana", "initials": "D"}, {"family": "Reiter", "given": "Robert E", "initials": "RE"}, {"family": "Rubin", "given": "Mark A", "initials": "MA"}, {"family": "Ryan", "given": "Charles J", "initials": "CJ"}, {"family": "Saad", "given": "Fred", "initials": "F"}, {"family": "Sade", "given": "Juan Pablo", "initials": "JP"}, {"family": "Sartor", "given": "Oliver", "initials": "O"}, {"family": "Scher", "given": "Howard I", "initials": "HI"}, {"family": "Sharifi", "given": "Nima", "initials": "N"}, {"family": "Skoneczna", "given": "Iwona", "initials": "I"}, {"family": "Soule", "given": "Howard", "initials": "H"}, {"family": "Spratt", "given": "Daniel E", "initials": "DE"}, {"family": "Srinivas", "given": "Sandy", "initials": "S"}, {"family": "Sternberg", "given": "Cora N", "initials": "CN"}, {"family": "Steuber", "given": "Thomas", "initials": "T"}, {"family": "Suzuki", "given": "Hiroyoshi", "initials": "H"}, {"family": "Sydes", "given": "Matthew R", "initials": "MR"}, {"family": "Taplin", "given": "Mary-Ellen", "initials": "ME"}, {"family": "Tilki", "given": "Derya", "initials": "D"}, {"family": "T\u00fcrkeri", "given": "Levent", "initials": "L"}, {"family": "Turco", "given": "Fabio", "initials": "F"}, {"family": "Uemura", "given": "Hiroji", "initials": "H"}, {"family": "Uemura", "given": "Hirotsugu", "initials": "H"}, {"family": "\u00dcr\u00fcn", "given": "Y\u00fcksel", "initials": "Y"}, {"family": "Vale", "given": "Claire L", "initials": "CL"}, {"family": "van Oort", "given": "Inge", "initials": "I"}, {"family": "Vapiwala", "given": "Neha", "initials": "N"}, {"family": "Walz", "given": "Jochen", "initials": "J"}, {"family": "Yamoah", "given": "Kosj", "initials": "K"}, {"family": "Ye", "given": "Dingwei", "initials": "D"}, {"family": "Yu", "given": "Evan Y", "initials": "EY"}, {"family": "Zapatero", "given": "Almudena", "initials": "A"}, {"family": "Zilli", "given": "Thomas", "initials": "T"}, {"family": "Omlin", "given": "Aurelius", "initials": "A"}], "type": "journal article", "published": "2023-03-03", "journal": {"title": "Eur J Cancer", "issn": "1879-0852", "volume": "185", "pages": "178-215", "issn-l": "0959-8049"}, "abstract": "Innovations in imaging and molecular characterisation together with novel treatment options have improved outcomes in advanced prostate cancer. However, we still lack high-level evidence in many areas relevant to making management decisions in daily clinical practise. The 2022 Advanced Prostate Cancer Consensus Conference (APCCC 2022) addressed some questions in these areas to supplement guidelines that mostly are based on level 1 evidence.\n\nTo present the voting results of the APCCC 2022.\n\nThe experts voted on controversial questions where high-level evidence is mostly lacking: locally advanced prostate cancer; biochemical recurrence after local treatment; metastatic hormone-sensitive, non-metastatic, and metastatic castration-resistant prostate cancer; oligometastatic prostate cancer; and managing side effects of hormonal therapy. A panel of 105 international prostate cancer experts voted on the consensus questions.\n\nThe panel voted on 198 pre-defined questions, which were developed by 117 voting and non-voting panel members prior to the conference following a modified Delphi process. A total of 116 questions on metastatic and/or castration-resistant prostate cancer are discussed in this manuscript. In 2022, the voting was done by a web-based survey because of COVID-19 restrictions.\n\nThe voting reflects the expert opinion of these panellists and did not incorporate a standard literature review or formal meta-analysis. The answer options for the consensus questions received varying degrees of support from panellists, as reflected in this article and the detailed voting results are reported in the supplementary material. We report here on topics in metastatic, hormone-sensitive prostate cancer (mHSPC), non-metastatic, castration-resistant prostate cancer (nmCRPC), metastatic castration-resistant prostate cancer (mCRPC), and oligometastatic and oligoprogressive prostate cancer.\n\nThese voting results in four specific areas from a panel of experts in advanced prostate cancer can help clinicians and patients navigate controversial areas of management for which high-level evidence is scant or conflicting and can help research funders and policy makers identify information gaps and consider what areas to explore further. However, diagnostic and treatment decisions always have to be individualised based on patient characteristics, including the extent and location of disease, prior treatment(s), co-morbidities, patient preferences, and treatment recommendations and should also incorporate current and emerging clinical evidence and logistic and economic factors. Enrolment in clinical trials is strongly encouraged. Importantly, APCCC 2022 once again identified important gaps where there is non-consensus and that merit evaluation in specifically designed trials.\n\nThe Advanced Prostate Cancer Consensus Conference (APCCC) provides a forum to discuss and debate current diagnostic and treatment options for patients with advanced prostate cancer. The conference aims to share the knowledge of international experts in prostate cancer with healthcare providers worldwide. At each APCCC, an expert panel votes on pre-defined questions that target the most clinically relevant areas of advanced prostate cancer treatment for which there are gaps in knowledge. The results of the voting provide a practical guide to help clinicians discuss therapeutic options with patients and their relatives as part of shared and multidisciplinary decision-making. This report focuses on the advanced setting, covering metastatic hormone-sensitive prostate cancer and both non-metastatic and metastatic castration-resistant prostate cancer.\n\nReport of the results of APCCC 2022 for the following topics: mHSPC, nmCRPC, mCRPC, and oligometastatic prostate cancer.\n\nAt APCCC 2022, clinically important questions in the management of advanced prostate cancer management were identified and discussed, and experts voted on pre-defined consensus questions. The report of the results for metastatic and/or castration-resistant prostate cancer is summarised here.", "doi": "10.1016/j.ejca.2023.02.018", "pmid": "37003085", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0959-8049(23)00110-7"}], "notes": [], "created": "2023-04-20T17:40:52.720Z", "modified": "2023-04-20T17:40:52.732Z"}, {"entity": "publication", "iuid": "7af7ee094d4a43fdb14612045b40587b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7af7ee094d4a43fdb14612045b40587b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7af7ee094d4a43fdb14612045b40587b"}}, "title": "Optimising conditions and environments for digital participation in later life: A macro-meso-micro framework of partnership-building.", "authors": [{"family": "Reuter", "given": "Arlind", "initials": "A"}, {"family": "Xu", "given": "Wenqian", "initials": "W"}, {"family": "Iwarsson", "given": "Susanne", "initials": "S"}, {"family": "Olsson", "given": "Tobias", "initials": "T"}, {"family": "Schmidt", "given": "Steven M", "initials": "SM"}], "type": "journal article", "published": "2023-03-02", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "14", "pages": "1107024", "issn-l": "1664-1078"}, "abstract": "The ongoing digitalisation of societies, exacerbated by the COVID-19 pandemic, has led to increased efforts to ensure the digital inclusion of older adults. Digital inclusion strategies throughout the COVID-19 pandemic predominantly focused on increasing access and basic digital literacy of Information and Communication Technologies (ICTs) for all members of society. Older adults, who are more likely to experience digital exclusion, are amongst the target groups of digital inclusion strategies. We propose that beyond digital inclusion, there is a need to focus on digital participation and optimise opportunities for everyone to participate in communities and society in post-pandemic times. Creative digital skills are the foundation of digital participation and can lead to a variety of contributions. Digital participation offers conditions that support agency and active contributions in a digitalised society. Taking macro-, meso-, and micro-level enablers of digital participation in later life into account, we argue for the establishment and implementation of multi-layered and multisectoral partnerships that address environmental factors (including social and physical dimensions) of digital participation and create opportunities for diverse, meaningful and fulfilling engagement with ICTs in later life. The partnership approach can be used in designing and implementing digital participation programmes and should be further evaluated against the needs and lived experiences of older individuals. Foresighted research is needed to investigate key factors of effective partnerships for optimising environments for digital participation in later life.", "doi": "10.3389/fpsyg.2023.1107024", "pmid": "36936014", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10017487"}], "notes": [], "created": "2023-04-21T16:10:59.315Z", "modified": "2023-04-21T16:10:59.331Z"}, {"entity": "publication", "iuid": "bec28b7a63e44bd58fc76b207fe907d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bec28b7a63e44bd58fc76b207fe907d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bec28b7a63e44bd58fc76b207fe907d5"}}, "title": "Prevalence and Characteristics Associated With Post-COVID-19 Condition Among Nonhospitalized Adolescents and Young Adults.", "authors": [{"family": "Selvakumar", "given": "Joel", "initials": "J"}, {"family": "Havdal", "given": "Lise Beier", "initials": "LB"}, {"family": "Drevvatne", "given": "Martin", "initials": "M"}, {"family": "Brodwall", "given": "Elias Myrstad", "initials": "EM"}, {"family": "Lund Berven", "given": "Lise", "initials": "L"}, {"family": "Stiansen-Sonerud", "given": "Tonje", "initials": "T"}, {"family": "Einvik", "given": "Gunnar", "initials": "G"}, {"family": "Leegaard", "given": "Truls Michael", "initials": "TM"}, {"family": "Tjade", "given": "Trygve", "initials": "T"}, {"family": "Michelsen", "given": "Annika E", "initials": "AE"}, {"family": "Mollnes", "given": "Tom Eirik", "initials": "TE"}, {"family": "Lund-Johansen", "given": "Fridtjof", "initials": "F"}, {"family": "Holm\u00f8y", "given": "Trygve", "initials": "T"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Sandler", "given": "Carolina X", "initials": "CX"}, {"family": "Cvejic", "given": "Erin", "initials": "E"}, {"family": "Lloyd", "given": "Andrew R", "initials": "AR"}, {"family": "Wyller", "given": "Vegard Bruun Bratholm", "initials": "VBB"}], "type": "journal article", "published": "2023-03-01", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "volume": "6", "issue": "3", "pages": "e235763", "issn-l": null}, "abstract": "The prevalence and baseline risk factors of post-COVID-19 condition (PCC) remain unresolved among the large number of young people who experienced mild COVID-19.\n\nTo determine the point prevalence of PCC 6 months after the acute infection, to determine the risk of development of PCC adjusted for possible confounders, and to explore a broad range of potential risk factors.\n\nThis cohort study included nonhospitalized individuals from 2 counties in Norway between ages 12 and 25 years who underwent reverse transcription-polymerase chain reaction (RT-PCR) testing. At the early convalescent stage and at 6-month follow-up, participants underwent a clinical examination; pulmonary, cardiac, and cognitive functional testing; immunological and organ injury biomarker analyses; and completion of a questionnaire. Participants were classified according to the World Health Organization case definition of PCC at follow-up. Association analyses of 78 potential risk factors were performed.\n\nSARS-CoV-2 infection.\n\nThe point prevalence of PCC 6 months after RT-PCR testing in the SARS-CoV-2-positive and SARS-CoV-2-negative groups, and the risk difference with corresponding 95% CIs.\n\nA total of 404 individuals testing positive for SARS-CoV-2 and 105 individuals testing negative were enrolled (194 male [38.1%]; 102 non-European [20.0%] ethnicity). A total of 22 of the SARS-CoV-2-positive and 4 of the SARS-CoV-2-negative individuals were lost to follow-up, and 16 SARS-CoV-2-negative individuals were excluded due to SARS-CoV-2 infection in the observational period. Hence, 382 SARS-CoV-2-positive participants (mean [SD] age, 18.0 [3.7] years; 152 male [39.8%]) and 85 SARS-CoV-2-negative participants (mean [SD] age, 17.7 [3.2] years; 31 male [36.5%]) could be evaluated. The point prevalence of PCC at 6 months was 48.5% in the SARS-CoV-2-positive group and 47.1% in the control group (risk difference, 1.5%; 95% CI, -10.2% to 13.1%). SARS-CoV-2 positivity was not associated with the development of PCC (relative risk [RR], 1.06; 95% CI, 0.83 to 1.37; final multivariable model utilizing modified Poisson regression). The main risk factor for PCC was symptom severity at baseline (RR, 1.41; 95% CI, 1.27-1.56). Low physical activity (RR, 0.96; 95% CI, 0.92-1.00) and loneliness (RR, 1.01; 95% CI, 1.00-1.02) were also associated, while biological markers were not. Symptom severity correlated with personality traits.\n\nThe persistent symptoms and disability that characterize PCC are associated with factors other than SARS-CoV-2 infection, including psychosocial factors. This finding raises questions about the utility of the World Health Organization case definition and has implications for the planning of health care services as well as for further research on PCC.", "doi": "10.1001/jamanetworkopen.2023.5763", "pmid": "36995712", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC10064252"}, {"db": "pii", "key": "2802893"}], "notes": [], "created": "2023-04-21T15:52:21.113Z", "modified": "2023-04-21T15:53:16.684Z"}, {"entity": "publication", "iuid": "81e376782a4948a7aa3e7bdc7c9c1609", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/81e376782a4948a7aa3e7bdc7c9c1609.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/81e376782a4948a7aa3e7bdc7c9c1609"}}, "title": "Frequent use of IGHV3-30-3 in SARS-CoV-2 neutralizing antibody responses.", "authors": [{"family": "Pushparaj", "given": "Pradeepa", "initials": "P"}, {"family": "Nicoletto", "given": "Andrea", "initials": "A"}, {"family": "Dopico", "given": "Xaquin Castro", "initials": "XC"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Kim", "given": "Sungyong", "initials": "S"}, {"family": "Ekstr\u00f6m", "given": "Simon", "initials": "S"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Corcoran", "given": "Martin", "initials": "M"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}], "type": "journal article", "published": "2023-03-01", "journal": {"title": "Front Virol", "issn": "2673-818X", "issn-l": null, "volume": "3", "issue": null, "pages": "1128253"}, "abstract": "The antibody response to SARS-CoV-2 shows biased immunoglobulin heavy chain variable (IGHV) gene usage, allowing definition of genetic signatures for some classes of neutralizing antibodies. We investigated IGHV gene usage frequencies by sorting spike-specific single memory B cells from individuals infected with SARS-CoV-2 early in the pandemic. From two study participants and 703 spikespecific B cells, the most used genes were IGHV1-69, IGHV3-30-3, and IGHV3-30. Here, we focused on the IGHV3-30 group of genes and an IGHV3-30-3-using ultrapotent neutralizing monoclonal antibody, CAB-F52, which displayed broad neutralizing activity also in its germline-reverted form. IGHV3-30-3 is encoded by a region of the IGH locus that is highly variable at both the allelic and structural levels. Using personalized IG genotyping, we found that 4 of 14 study participants lacked the IGHV3-30-3 gene on both chromosomes, raising the question if other, highly similar IGHV genes could substitute for IGHV3-30-3 in persons lacking this gene. In the context of CAB-F52, we found that none of the tested IGHV3-33 alleles, but several IGHV3-30 alleles could substitute for IGHV3-30-3, suggesting functional redundancy between the highly homologous IGHV3-30 and IGHV3-30-3 genes for this antibody.", "doi": "10.3389/fviro.2023.1128253", "pmid": "37041983", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC7614418"}, {"db": "URL", "key": "https://www.frontiersin.org/articles/10.3389/fviro.2023.1128253/full#supplementary-material", "description": "https://www.frontiersin.org/articles/10.3389/fviro.2023.1128253/full#supplementary-material"}], "notes": [], "created": "2023-04-12T17:02:23.880Z", "modified": "2023-04-12T17:03:49.485Z"}, {"entity": "publication", "iuid": "66de20f884d741cf9c6fe15b97766203", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66de20f884d741cf9c6fe15b97766203.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66de20f884d741cf9c6fe15b97766203"}}, "title": "Tissue factor activity of small and large extracellular vesicles in different diseases.", "authors": [{"family": "Sachetto", "given": "Ana T A", "initials": "ATA"}, {"family": "Archibald", "given": "Sierra J", "initials": "SJ"}, {"family": "Hisada", "given": "Yohei", "initials": "Y"}, {"family": "Rosell", "given": "Axel", "initials": "A"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "van Es", "given": "Nick", "initials": "N"}, {"family": "Nieuwland", "given": "Rienk", "initials": "R"}, {"family": "Campbell", "given": "Robert A", "initials": "RA"}, {"family": "Middleton", "given": "Elizabeth A", "initials": "EA"}, {"family": "Rondina", "given": "Matthew T", "initials": "MT"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "Res Pract Thromb Haemost", "issn": "2475-0379", "volume": "7", "issue": "3", "pages": "100124", "issn-l": null}, "abstract": "Circulating procoagulant extracellular vesicles (EVs) are increased in diseases, such as cancer, sepsis, and COVID-19. EV tissue factor (TF) activity is associated with disseminated intravascular coagulation in sepsis and venous thrombosis in patients with pancreatic cancer and COVID-19. EVs are commonly isolated by centrifugation at \u223c20,000 g.\n\nIn this study, we analyzed the TF activity of 2 EV populations enriched for large and small EVs in patients with either sepsis, pancreatic cancer, or COVID-19.\n\nEVs were isolated from plasma by sequential centrifugation at 20,000 g (large EVs, LEVs) and then 100,000 g (small EVs, SEVs). We analyzed EVs from plasma prepared from whole blood samples from healthy individuals with or without lipopolysaccharide (LPS) stimulation as well as EVs from plasma samples from patients with either sepsis, pancreatic cancer, or COVID-19. TF-dependent (EV-TF activity) and TF-independent factor Xa (FXa) generation of the EVs was measured.\n\nLPS increased EV-TF activity in LEVs but not SEVs. Similarly, in 2 patients with sepsis who had EV-TF activity above the background of the assay we observed EV-TF activity in LEVs but not SEVs. Patients with pancreatic cancer or COVID-19 had circulating EV-TF activity in both LEVs and SEVs.\n\nWe recommend that EVs are isolated from plasma from patients by centrifugation at 100,000 g rather than 20,000 g to obtain a more accurate measure of levels of circulating EV-TF activity.", "doi": "10.1016/j.rpth.2023.100124", "pmid": "37012986", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10015082"}, {"db": "pii", "key": "S2475-0379(23)00095-X"}], "notes": [], "created": "2023-04-12T16:53:04.397Z", "modified": "2023-04-20T17:35:04.601Z"}, {"entity": "publication", "iuid": "5c1c1d407c184180b0f336a10852eb68", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c1c1d407c184180b0f336a10852eb68.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c1c1d407c184180b0f336a10852eb68"}}, "title": "The effect of time spent sitting and excessive gaming on the weight status, and perceived weight stigma among Taiwanese young adults.", "authors": [{"family": "Kamolthip", "given": "Ruckwongpatr", "initials": "R"}, {"family": "Yang", "given": "Yung-Ning", "initials": "YN"}, {"family": "Latner", "given": "Janet D", "initials": "JD"}, {"family": "O'Brien", "given": "Kerry S", "initials": "KS"}, {"family": "Chang", "given": "Yen-Ling", "initials": "YL"}, {"family": "Lin", "given": "Chien-Chin", "initials": "CC"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": "9", "issue": "3", "pages": "e14298", "issn-l": null}, "abstract": "During the COVID-19 pandemic, physical inactivity and sedentary behaviors (i.e., longer sitting time and excessive gaming) increased because governments across the globe adopted stringent mitigation strategies such as social distancing and lockdowns to curb the spread of the virus. Excessive gaming was one of the coping mechanisms used to deal with the pressure associated with the pandemic. Moreover, perceived weight stigma (PWS) and weight status became more salient concerns among young adults during the COVID-19 pandemic. The current study sought to investigate the relationship between time spent sitting, excessive gaming, weight status, and PWS of Taiwanese Young adults. Additionally, weight status and PWS were examined as mediators between both sedentary behaviors.\n\nThis cross-sectional study involved 600 participants who were recruited through Taiwan universities. All participants completed a demographic questionnaire (including weight and height) and self-report measures including the International Physical Activity Questionnaire short form (IPAQ-SF), the Perceived Weight Stigma Scale (PWSS), and the Internet Gaming Disorder Scale-short form (IGDS9-SF). PROCESS model was performed to test the potential mediation roles of weight status and PWS. Moreover, we categorized participants into two groups based on the sitting-time item in the IPAQ-SF: students whose sitting time was less than 8 h daily, and those more than 8 h daily.\n\nThe group that had less than 8 h had significantly higher PWS and IGDS9-SF scores than the other group. Sitting time was negatively associated with weight status, PWS, and IGDS9-SF. Additionally, we found a significantly direct effect between time spent sitting and excessive gaming. Both weight status and PWS were significant mediators in the association between time spent sitting and excessive gaming.Conclusions: The present study demonstrated important negative correlates of excessive sedentary behaviors. Prevention efforts should focus on promoting physical activity and providing information to decrease sedentary behavior among university students.", "doi": "10.1016/j.heliyon.2023.e14298", "pmid": "36938463", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10018563"}, {"db": "pii", "key": "S2405-8440(23)01505-0"}], "notes": [], "created": "2023-04-21T16:09:37.800Z", "modified": "2023-04-21T16:09:37.814Z"}, {"entity": "publication", "iuid": "befbcb1b88f84f8ab93f91ad0015f19e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/befbcb1b88f84f8ab93f91ad0015f19e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/befbcb1b88f84f8ab93f91ad0015f19e"}}, "title": "Prevalence of ongoing or previous SARS-CoV-2 infection among dental personnel - the Swedish experience.", "authors": [{"family": "Fredriksson", "given": "Lars", "initials": "L"}, {"family": "Cederlund", "given": "Andreas", "initials": "A"}, {"family": "Murray", "given": "My", "initials": "M"}, {"family": "Jansson", "given": "Leif", "initials": "L"}, {"family": "Skott", "given": "Pia", "initials": "P"}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "Acta Odontol Scand", "issn": "1502-3850", "pages": "119-123", "volume": "81", "issue": "2", "issn-l": null}, "abstract": "The seroprevalence of SARS-CoV-2 infection was approximately similar to that in healthcare personnel, and approximately equal compared to that in the general population.\n\nWe carried out an observational cohort study from March to June 2020, including 341 employees randomly selected from Public Dental Service in the County of Stockholm. The primary outcome variable was the prevalence of SARS-CoV-2 RNA and/or antibodies against SARS-CoV-2. Throat samples were analysed for SARS-CoV-2 RNA. Venous blood was collected to detect antibodies against SARS-CoV-2 using the Luminex analysis tool (immunoassay) and ELISA. Logistic regression analysis was used to compare the independent groups and calculate the unadjusted odds ratio.\n\nTo investigate whether personnel in a public dental clinic had a higher frequency of ongoing or previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection than hospital healthcare workers or the general public in Stockholm during weeks 23-25 in 2020.\n\nThe mean age of the participants was 50.1 years, and 11.7% were male. The prevalence of SARS-CoV-2 RNA and/or antibodies against SARS-CoV-2 was 12.0% (95% confidence interval 8.8-16.0). Among them, 82.5% reported symptoms and 85.4% were on sick-leave between March and June 2020.", "doi": "10.1080/00016357.2022.2095023", "pmid": "35771959", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-19T05:28:40.708Z", "modified": "2023-02-27T17:23:18.839Z"}, {"entity": "publication", "iuid": "a6335c7e323041f087c9920a70e0af66", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6335c7e323041f087c9920a70e0af66.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6335c7e323041f087c9920a70e0af66"}}, "title": "Postmortem lung and heart examination of COVID-19 patients in a case series from Jordan.", "authors": [{"family": "Abdaljaleel", "given": "Maram", "initials": "M"}, {"family": "Tawalbeh", "given": "Isra", "initials": "I"}, {"family": "Sallam", "given": "Malik", "initials": "M"}, {"family": "Hani", "given": "Amjad Bani", "initials": "AB"}, {"family": "Al-Abdallat", "given": "Imad M", "initials": "IM"}, {"family": "Omari", "given": "Baheth Al", "initials": "BA"}, {"family": "Al-Mustafa", "given": "Sahar", "initials": "S"}, {"family": "Abder-Rahman", "given": "Hasan", "initials": "H"}, {"family": "Abbas", "given": "Adnan Said", "initials": "AS"}, {"family": "Zureigat", "given": "Mahmoud", "initials": "M"}, {"family": "Al-Abbadi", "given": "Mousa A", "initials": "MA"}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "J Pathol Transl Med", "issn": "2383-7837", "volume": "57", "issue": "2", "pages": "102-112", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) has emerged as a pandemic for more than 2 years. Autopsy examination is an invaluable tool to understand the pathogenesis of emerging infections and their consequent mortalities. The aim of the current study was to present the lung and heart pathological findings of COVID-19-positive autopsies performed in Jordan.\n\nThe study involved medicolegal cases, where the cause of death was unclear and autopsy examination was mandated by law. We included the clinical and pathologic findings of routine gross and microscopic examination of cases that were positive for COVID-19 at time of death. Testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was confirmed through molecular detection by real-time polymerase chain reaction, serologic testing for IgM and electron microscope examination of lung samples.\n\nSeventeen autopsies were included, with male predominance (76.5%), Jordanians (70.6%), and 50 years as the mean age at time of death. Nine out of 16 cases (56.3%) had co-morbidities, with one case lacking such data. Histologic examination of lung tissue revealed diffuse alveolar damage in 13/17 cases (76.5%), and pulmonary microthrombi in 8/17 cases (47.1%). Microscopic cardiac findings were scarcely detected. Two patients died as a direct result of acute cardiac disease with limited pulmonary findings.\n\nThe detection of SARS-CoV-2 in postmortem examination can be an incidental or contributory finding which highlights the value of autopsy examination to determine the exact cause of death in controversial cases.", "doi": "10.4132/jptm.2023.01.30", "pmid": "36950812", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10028009"}, {"db": "pii", "key": "jptm.2023.01.30"}], "notes": [], "created": "2023-04-21T16:06:18.219Z", "modified": "2023-04-21T16:06:18.249Z"}, {"entity": "publication", "iuid": "b7acd11c71a747c680184bf65a33eab4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b7acd11c71a747c680184bf65a33eab4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b7acd11c71a747c680184bf65a33eab4"}}, "title": "Ending tuberculosis in Europe - resetting the course in the post-COVID-19 era.", "authors": [{"family": "Ammon", "given": "Andrea", "initials": "A"}, {"family": "Kluge", "given": "Hans", "initials": "H"}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "28", "issue": "12", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2023.28.12.2300164", "pmid": "36951785", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10037663"}], "notes": [], "created": "2023-04-21T16:05:58.119Z", "modified": "2023-04-21T16:05:58.133Z"}, {"entity": "publication", "iuid": "bc340dba244547368876643044926ea9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bc340dba244547368876643044926ea9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bc340dba244547368876643044926ea9"}}, "title": "Clinical Psychology and the COVID-19 Pandemic: A Mixed Methods Survey Among Members of the European Association of Clinical Psychology and Psychological Treatment (EACLIPT).", "authors": [{"family": "Asbrand", "given": "Julia", "initials": "J", "orcid": "0000-0003-2740-6070", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ec60c3248048dc9d2d6f6295532c82.json"}}, {"family": "Gerdes", "given": "Samantha", "initials": "S", "orcid": "0009-0005-5352-2878", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5baa03eb311c425abe9e7a6242f22a1b.json"}}, {"family": "Breedvelt", "given": "Josefien", "initials": "J", "orcid": "0000-0003-1864-1861", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ef1cfcb7b74c2ab3cb66fb32c3ef94.json"}}, {"family": "Guidi", "given": "Jenny", "initials": "J", "orcid": "0000-0001-6815-2738", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/723aedb65169433cb51b99314509c977.json"}}, {"family": "Hirsch", "given": "Colette", "initials": "C", "orcid": "0000-0003-3579-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/23f55b6faf8d4c8884beeb5bfabb26b2.json"}}, {"family": "Maercker", "given": "Andreas", "initials": "A", "orcid": "0000-0001-6925-3266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15a03c24689741fb919740b0e4dda05c.json"}}, {"family": "Douilliez", "given": "C\u00e9line", "initials": "C", "orcid": "0000-0001-8912-885X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d387fee028b944c9829f6053498b629e.json"}}, {"family": "Andersson", "given": "Gerhard", "initials": "G", "orcid": "0000-0003-4753-6745", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b4074e5f32e453598de03ffcd897f67.json"}}, {"family": "Debban\u00e9", "given": "Martin", "initials": "M", "orcid": "0000-0002-4677-8753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/974ab9e42dd84d5f8bc7968dadd26022.json"}}, {"family": "Cieslak", "given": "Roman", "initials": "R", "orcid": "0000-0002-2413-5343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc9c0ccb0bbb4952b0ef1902d6a92a37.json"}}, {"family": "Rief", "given": "Winfried", "initials": "W", "orcid": "0000-0002-7019-2250", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9e36a5b17d640ec8f3f3f4c185a521e.json"}}, {"family": "Bockting", "given": "Claudi", "initials": "C", "orcid": "0000-0002-9220-9244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/281735678af94747b23f8f95cf1696bf.json"}}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "Clin Psychol Eur", "issn": "2625-3410", "volume": "5", "issue": "1", "pages": "e8109", "issn-l": null}, "abstract": "The COVID-19 pandemic has affected people globally both physically and psychologically. The increased demands for mental health interventions provided by clinical psychologists, psychotherapists and mental health care professionals, as well as the rapid change in work setting (e.g., from face-to-face to video therapy) has proven challenging. The current study investigates European clinical psychologists and psychotherapists' views on the changes and impact on mental health care that occurred due to the COVID-19 pandemic. It further aims to explore individual and organizational processes that assist clinical psychologists' and psychotherapists' in their new working conditions, and understand their needs and priorities.\n\nMembers of the European Association of Clinical Psychology and Psychological Treatment (EACLIPT) were invited (N = 698) to participate in a survey with closed and open questions covering their experiences during the first wave of the pandemic from June to September 2020. Participants (n = 92) from 19 European countries, mostly employed in universities or hospitals, completed the online survey.\n\nResults of qualitative and quantitative analyses showed that clinical psychologists and psychotherapists throughout the first wave of the COVID-19 pandemic managed to continue to provide treatments for patients who were experiencing emotional distress. The challenges (e.g., maintaining a working relationship through video treatment) and opportunities (e.g., more flexible working hours) of working through this time were identified.\n\nRecommendations for mental health policies and professional organizations are identified, such as clear guidelines regarding data security and workshops on conducting video therapy.", "doi": "10.32872/cpe.8109", "pmid": "37064999", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10103154"}, {"db": "pii", "key": "cpe.8109"}], "notes": [], "created": "2023-04-20T17:22:54.225Z", "modified": "2023-04-20T17:22:54.619Z"}, {"entity": "publication", "iuid": "92d1c3da53bc4fffb69d6dfba60ffa5d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/92d1c3da53bc4fffb69d6dfba60ffa5d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/92d1c3da53bc4fffb69d6dfba60ffa5d"}}, "title": "At-home sampling to meet geographical challenges for serological assessment of SARS-CoV-2 exposure in a rural region of northern Sweden, March to May 2021: a retrospective cohort study.", "authors": [{"family": "Bystr\u00f6m", "given": "Julia Wigren", "initials": "JW"}, {"family": "Vikstr\u00f6m", "given": "Linnea", "initials": "L"}, {"family": "Rosendal", "given": "Ebba", "initials": "E"}, {"family": "Gr\u00f6ning", "given": "Remigius", "initials": "R"}, {"family": "Gwon", "given": "Yong-Dae", "initials": "Y"}, {"family": "Nilsson", "given": "Emma", "initials": "E"}, {"family": "Sharma", "given": "Atin", "initials": "A"}, {"family": "Espaillat", "given": "Akbar", "initials": "A"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Puhar", "given": "Andrea", "initials": "A"}, {"family": "Cava", "given": "Felipe", "initials": "F"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Thunberg", "given": "Therese", "initials": "T"}, {"family": "Monsen", "given": "Tor", "initials": "T"}, {"family": "Elgh", "given": "Fredrik", "initials": "F"}, {"family": "Evander", "given": "Magnus", "initials": "M"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Forsell", "given": "Mattias Ne", "initials": "MN"}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "28", "issue": "13", "pages": null}, "abstract": "BackgroundThe current SARS-CoV-2 pandemic has highlighted a need for easy and safe blood sampling in combination with accurate serological methodology. Venipuncture for testing is usually performed by trained staff at healthcare centres. Long travel distances to healthcare centres in rural regions may introduce a bias of testing towards relatively large communities with closer access. Rural regions are therefore often not represented in population-based data.AimThe aim of this retrospective cohort study was to develop and implement a strategy for at-home testing in a rural region of Sweden during spring 2021, and to evaluate its role to provide equal health care for its inhabitants.MethodsWe developed a sensitive method to measure antibodies to the S-protein of SARS-CoV-2 and optimised this assay for clinical use together with a strategy of at-home capillary blood sampling.ResultsWe demonstrated that our ELISA gave comparable results after analysis of capillary blood or serum from SARS-CoV-2-experienced individuals. We demonstrated stability of the assay under conditions that reflected temperature and humidity during winter or summer. By assessment of capillary blood samples from 4,122 individuals, we could show both feasibility of the strategy and that implementation shifted the geographical spread of testing in favour of rural areas.ConclusionImplementation of at-home sampling enabled citizens living in remote rural areas access to centralised and sensitive laboratory antibody tests. The strategy for testing used here could therefore enable disease control authorities to get rapid access to information concerning immunity to infectious diseases, even across vast geographical distance.", "doi": "10.2807/1560-7917.ES.2023.28.13.2200432", "pmid": "36995373", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null, "Funder: VR": null, "Funder: Vinnova": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC10064644"}], "notes": [], "created": "2023-04-12T16:46:21.928Z", "modified": "2023-04-12T16:57:03.602Z"}, {"entity": "publication", "iuid": "c156297880874d289605794386f2ba0f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c156297880874d289605794386f2ba0f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c156297880874d289605794386f2ba0f"}}, "title": "Arrival flight efficiency in pre- and post-Covid-19 pandemics.", "authors": [{"family": "Lemetti", "given": "Anastasia", "initials": "A"}, {"family": "Hardell", "given": "Henrik", "initials": "H"}, {"family": "Polishchuk", "given": "Tatiana", "initials": "T"}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "J Air Transp Manag", "issn": "1873-2089", "volume": "107", "pages": "102327", "issn-l": null}, "abstract": "Covid-19 pandemic affected aviation severely, resulting in unprecedented reduction of air traffic. While aviation is slowly re-gaining traffic volumes, we use the opportunity to study the arrival performance in the Terminal Maneuvering Area (TMA) in non-congested scenarios. Applying flight efficiency and environmental performance indicators (PIs) to the historical data of arrivals to Stockholm Arlanda and Gothenburg Landvetter airports, we discover noticeable inefficiencies, despite significant reduction of traffic intensity. We analyze the impact of such factors as weather and traffic intensity on arrival efficiency in isolated scenarios when only one factor dominates: isolated scenario with low traffic and isolated scenario with good weather conditions. Our analysis uncovers that weather has a stronger influence than traffic intensity on the vertical efficiency, while traffic intensity has stronger effect on the lateral efficiency. Impact of traffic intensity on the lateral efficiency might be explained by frequent hold-on patterns and flight trajectory extensions due to vectoring in high traffic conditions. Further investigation is needed to explain weather and vertical/lateral efficiency correlations, the conclusions might be country-specific.", "doi": "10.1016/j.jairtraman.2022.102327", "pmid": "36408128", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0969-6997(22)00146-6"}, {"db": "pmc", "key": "PMC9647021"}], "notes": [], "created": "2022-11-22T10:03:00.151Z", "modified": "2022-11-22T10:03:11.662Z"}, {"entity": "publication", "iuid": "c0d8bacc5149404fb602a317c0f3e022", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c0d8bacc5149404fb602a317c0f3e022.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c0d8bacc5149404fb602a317c0f3e022"}}, "title": "Structures for collaboration and networked adaptation: Emerging themes from the COVID-19 pandemic", "authors": [{"family": "Antonsen", "given": "PhD, Stian", "initials": "PS"}, {"family": "Haavik", "given": "PhD, Torgeir Kolst\u00f8", "initials": "PTK"}, {"family": "Frykmer", "given": "PhD, Tove", "initials": "PT"}, {"family": "Gj\u00f8sund", "given": "Gudveig", "initials": "G"}], "type": "journal-article", "published": "2023-02-28", "journal": {"title": "J Emerg Manag", "issn": "1543-5865", "issn-l": null, "volume": "21", "issue": "7", "pages": "71-84"}, "abstract": null, "doi": "10.5055/jem.0705", "pmid": null, "labels": {"Category: Social Science & Humanities": null, "Type: Other": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:12:23.449Z", "modified": "2023-10-04T08:17:14.166Z"}, {"entity": "publication", "iuid": "1bf2e234720541e487e3d31dd629578b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1bf2e234720541e487e3d31dd629578b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1bf2e234720541e487e3d31dd629578b"}}, "title": "Editorial: Health service management and leadership: COVID-style.", "authors": [{"family": "Dadich", "given": "Ann", "initials": "A"}, {"family": "Buttigieg", "given": "Sandra", "initials": "S"}, {"family": "Macassa", "given": "Gloria", "initials": "G"}, {"family": "West", "given": "Thomas", "initials": "T"}], "type": "editorial", "published": "2023-02-28", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "11", "pages": "1141055", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2023.1141055", "pmid": "36926174", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10011686"}], "notes": [], "created": "2023-04-21T16:13:05.921Z", "modified": "2023-04-21T16:13:05.938Z"}, {"entity": "publication", "iuid": "3af35c66db2c41009aed93edbb5d0054", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3af35c66db2c41009aed93edbb5d0054.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3af35c66db2c41009aed93edbb5d0054"}}, "title": "Worldwide Estimation of Parental Acceptance of COVID-19 Vaccine for Their Children: A Systematic Review and Meta-Analysis.", "authors": [{"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2023-02-24", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "11", "issue": "3", "issn-l": null}, "abstract": "Currently, the best method to well control the spread of COVID-19 without severe mental health problems is to reach herd immunity. Therefore, the vaccination rate of the COVID-19 vaccine is critical. Among the populations, children are the vulnerable ones to get vaccinated; therefore, it is important to assess parents' and guardians' willingness to have their children vaccinated. The present systematic review and meta-analysis synthesized evidence to estimate the parents' acceptance rate of COVID-19 vaccination toward their children. Additionally, factors explaining the acceptance rate were investigated. Four academic databases (PubMed, Scopus, Web of Science, and ProQuest) together with Google Scholar were searched, and the references of the included publications were searched as well. Using the PECO-S framework (population, exposure, comparison, outcome, and study design), observational studies of cross-sectional, cohort, or case-control studies were included. The outcome was parents' or guardians' willingness to let their children be vaccinated. The studies included in the present review were restricted to English and peer-reviewed papers published between December 2019 and July 2022. A total of 98 papers across 69 different countries with 413,590 participants were included. The mean age of the parents was 39.10 (range: 18-70) years and that of their children was 8.45 (range: 0-18) years. The pooled estimated prevalence of parental acceptance to vaccinate their children with the COVID-19 vaccine was 57% (98 studies, 95% CI: 52-62%, I2: 99.92%, \u03c42: 0.06). Moreover, data collection time was a significant factor explaining parental willingness in the multivariable meta-regression, with a 13% decrease in parental willingness by each month increase in time, explaining 11.44% of variance. Qualitative synthesis results showed that parents' COVID-19 vaccine knowledge, trust in theCOVID-19 vaccine, and facilitators in vaccination (e.g., low cost, good vaccine accessibility, and government incentive) were significant factors for higher willingness, while mental health problems (e.g., having worries and psychological distress) were significant factors for lower willingness. Given that the acceptance rate was relatively low (57%) and does not achieve the requirement of herd immunity (i.e., 70%), governments and healthcare authorities should try to elevate parents' knowledge and trust in the COVID-19 vaccine, facilitate in vaccination, and reduce their mental difficulties to improve the overall vaccination rate among children.", "doi": "10.3390/vaccines11030533", "pmid": "36992117", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10051081"}, {"db": "pii", "key": "vaccines11030533"}], "notes": [], "created": "2023-04-21T15:55:33.559Z", "modified": "2023-04-21T15:55:33.576Z"}, {"entity": "publication", "iuid": "f1eb1c6f4d1f4c57b823461a287975eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1eb1c6f4d1f4c57b823461a287975eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1eb1c6f4d1f4c57b823461a287975eb"}}, "title": "Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia.", "authors": [{"family": "Palma Medina", "given": "Laura M", "initials": "LM"}, {"family": "Baba\u010di\u0107", "given": "Haris", "initials": "H"}, {"family": "Dzidic", "given": "Majda", "initials": "M"}, {"family": "Parke", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Garcia", "given": "Marina", "initials": "M"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Unge", "given": "Christian", "initials": "C"}, {"family": "Lourda", "given": "Magda", "initials": "M"}, {"family": "Kvedaraite", "given": "Egle", "initials": "E"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Muvva", "given": "Jagadeeswara Rao", "initials": "JR"}, {"family": "Cornillet", "given": "Martin", "initials": "M"}, {"family": "Emg\u00e5rd", "given": "Johanna", "initials": "J"}, {"family": "Moll", "given": "Kirsten", "initials": "K"}, {"family": "Karolinska K. I./K. COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Flodstr\u00f6m-Tullberg", "given": "Malin", "initials": "M"}, {"family": "Brighenti", "given": "Susanna", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J"}, {"family": "Malmberg", "given": "Karl-Johan", "initials": "KJ"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Svensson", "given": "Mattias", "initials": "M"}, {"family": "Chambers", "given": "Benedict J", "initials": "BJ"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Pernemalm", "given": "Maria", "initials": "M"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2023-02-24", "journal": {"title": "Respir Res", "issn": "1465-993X", "volume": "24", "issue": "1", "pages": "62", "issn-l": "1465-9921"}, "abstract": "COVID-19 remains a major public health challenge, requiring the development of tools to improve diagnosis and inform therapeutic decisions. As dysregulated inflammation and coagulation responses have been implicated in the pathophysiology of COVID-19 and sepsis, we studied their plasma proteome profiles to delineate similarities from specific features.\n\nWe measured 276 plasma proteins involved in Inflammation, organ damage, immune response and coagulation in healthy controls, COVID-19 patients during acute and convalescence phase, and sepsis patients; the latter included (i) community-acquired pneumonia (CAP) caused by Influenza, (ii) bacterial CAP, (iii) non-pneumonia sepsis, and (iv) septic shock patients.\n\nWe identified a core response to infection consisting of 42 proteins altered in both COVID-19 and sepsis, although higher levels of cytokine storm-associated proteins were evident in sepsis. Furthermore, microbiologic etiology and clinical endotypes were linked to unique signatures. Finally, through machine learning, we identified biomarkers, such as TRIM21, PTN and CASP8, that accurately differentiated COVID-19 from CAP-sepsis with higher accuracy than standard clinical markers.\n\nThis study extends the understanding of host responses underlying sepsis and COVID-19, indicating varying disease mechanisms with unique signatures. These diagnostic and severity signatures are candidates for the development of personalized management of COVID-19 and sepsis.", "doi": "10.1186/s12931-023-02364-y", "pmid": "36829233", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12931-023-02364-y"}, {"db": "pmc", "key": "PMC9950694"}], "notes": [], "created": "2023-02-27T17:22:27.856Z", "modified": "2023-02-27T17:29:11.649Z"}, {"entity": "publication", "iuid": "845ac1efd1a14178af13474487957dbd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/845ac1efd1a14178af13474487957dbd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/845ac1efd1a14178af13474487957dbd"}}, "title": "Risk factors for impaired respiratory function post COVID-19: A prospective cohort study of nonhospitalized and hospitalized patients.", "authors": [{"family": "Bj\u00f6rsell", "given": "Tove", "initials": "T"}, {"family": "Sundh", "given": "Josefin", "initials": "J"}, {"family": "Lange", "given": "Anna", "initials": "A"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Tevell", "given": "Staffan", "initials": "S"}, {"family": "Blomberg", "given": "Anders", "initials": "A"}, {"family": "Edin", "given": "Alicia", "initials": "A"}, {"family": "Normark", "given": "Johan", "initials": "J", "orcid": "0000-0001-5831-4369", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cab4f084027e4e4b8f0e5113a499e5c6.json"}}, {"family": "Cajander", "given": "Sara", "initials": "S"}], "type": "journal article", "published": "2023-02-23", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null}, "abstract": "Severe COVID-19 increases the risk for long-term respiratory impairment, but data after mild COVID-19 are scarce. Our aims were to determine risk factors for reduced respiratory function 3-6 months after COVID-19 infection and to investigate if reduced respiratory function would relate to impairment of exercise performance and breathlessness.\n\nPatients with COVID-19 were enrolled at the University Hospitals of Ume\u00e5 and \u00d6rebro, and Karlstad Central Hospital, Sweden. Disease severity was defined as mild (nonhospitalized), moderate (hospitalized with or without oxygen treatment), and severe (intensive care). Spirometry, including diffusion capacity (DLCO ), was performed 3-6 months after hospital discharge or study enrollment (for nonhospitalized patients). Breathlessness (defined as \u22651 according to the modified Medical Research Council scale) and functional exercise capacity (1-min sit-to-stand test; 1-MSTST) were assessed.\n\nBetween April 2020 and May 2021, 337 patients were enrolled in the study. Forced vital capacity and DLCO were significantly lower in patients with severe COVID-19. Among hospitalized patients, 20% had reduced DLCO , versus 4% in nonhospitalized. Breathlessness was found in 40.6% of the participants and was associated with impaired DLCO . A pathological desaturation or heart rate response was observed in 17% of participants during the 1-MSTST. However, this response was not associated with reduced DLCO .\n\nReduced DLCO was the major respiratory impairment 3-6 months following COVID-19, with hospitalization as the most important risk factor. The lack of association between impaired DLCO and pathological physiological responses to exertion suggests that these physiological responses are not primarily related to decreased lung function.", "doi": "10.1111/joim.13614", "pmid": "36815689", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-02-27T17:24:16.046Z", "modified": "2023-02-27T17:24:27.993Z"}, {"entity": "publication", "iuid": "b9313c5ab4074c5291baf361990a877c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9313c5ab4074c5291baf361990a877c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9313c5ab4074c5291baf361990a877c"}}, "title": "Inhaled ciclesonide in adults hospitalised with COVID-19: a randomised controlled open-label trial (HALT COVID-19).", "authors": [{"family": "Brodin", "given": "Daniel", "initials": "D"}, {"family": "Tornhammar", "given": "Per", "initials": "P", "orcid": "0000-0003-1043-1894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30bc2420c4c54a65986ab73c60d45def.json"}}, {"family": "Ueda", "given": "Peter", "initials": "P"}, {"family": "Krifors", "given": "Anders", "initials": "A"}, {"family": "Westerlund", "given": "Eli", "initials": "E", "orcid": "0000-0001-5453-1796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06c564d3974f4436bc6c93b94b99eff6.json"}}, {"family": "Athlin", "given": "Simon", "initials": "S"}, {"family": "Wojt", "given": "Sandra", "initials": "S"}, {"family": "Elvstam", "given": "Olof", "initials": "O"}, {"family": "Neumann", "given": "Anca", "initials": "A"}, {"family": "Elshani", "given": "Arsim", "initials": "A"}, {"family": "Giesecke", "given": "Julia", "initials": "J"}, {"family": "Edvardsson-K\u00e4llkvist", "given": "Jens", "initials": "J"}, {"family": "Bunpuckdee", "given": "Sayam", "initials": "S"}, {"family": "Unge", "given": "Christian", "initials": "C"}, {"family": "Larsson", "given": "Martin", "initials": "M"}, {"family": "Johansson", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Ljungberg", "given": "Johan", "initials": "J"}, {"family": "Lindell", "given": "Jonas", "initials": "J"}, {"family": "Hansson", "given": "Johan", "initials": "J"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Andersson", "given": "Daniel Peter", "initials": "DP", "orcid": "0000-0003-4655-4837", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e35f15e626c045c191bd14a522a85c0e.json"}}], "type": "randomized controlled trial", "published": "2023-02-22", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "13", "issue": "2", "pages": "e064374", "issn-l": "2044-6055"}, "abstract": "To assess the efficacy of inhaled ciclesonide in reducing the duration of oxygen therapy (an indicator of time to clinical improvement) among adults hospitalised with COVID-19.\n\nMulticentre, randomised, controlled, open-label trial.\n\n9 hospitals (3 academic hospitals and 6 non-academic hospitals) in Sweden between 1 June 2020 and 17 May 2021.\n\nAdults hospitalised with COVID-19 and receiving oxygen therapy.\n\nInhaled ciclesonide 320 \u00b5g two times a day for 14 days versus standard care.\n\nPrimary outcome was duration of oxygen therapy, an indicator of time to clinical improvement. Key secondary outcome was a composite of invasive mechanical ventilation/death.\n\nData from 98 participants were analysed (48 receiving ciclesonide and 50 receiving standard care; median (IQR) age, 59.5 (49-67) years; 67 (68%) men). Median (IQR) duration of oxygen therapy was 5.5 (3-9) days in the ciclesonide group and 4 (2-7) days in the standard care group (HR for termination of oxygen therapy 0.73 (95% CI 0.47 to 1.11), with the upper 95% CI being compatible with a 10% relative reduction in oxygen therapy duration, corresponding to a <1 day absolute reduction in a post-hoc calculation). Three participants in each group died/received invasive mechanical ventilation (HR 0.90 (95% CI 0.15 to 5.32)). The trial was discontinued early due to slow enrolment.\n\nIn patients hospitalised with COVID-19 receiving oxygen therapy, this trial ruled out, with 0.95 confidence, a treatment effect of ciclesonide corresponding to more than a 1 day reduction in duration of oxygen therapy. Ciclesonide is unlikely to improve this outcome meaningfully.\n\nNCT04381364.", "doi": "10.1136/bmjopen-2022-064374", "pmid": "36813503", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC9950582"}, {"db": "pii", "key": "bmjopen-2022-064374"}, {"db": "ClinicalTrials.gov", "key": "NCT04381364"}], "notes": [], "created": "2023-02-27T17:21:44.921Z", "modified": "2023-02-27T17:21:59.005Z"}, {"entity": "publication", "iuid": "24e7b24a49204215aa186411efb8ad01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24e7b24a49204215aa186411efb8ad01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24e7b24a49204215aa186411efb8ad01"}}, "title": "Attitudes of Swedish Language Twitter Users Toward COVID-19 Vaccination: Exploratory Qualitative Study.", "authors": [{"family": "Beirakdar", "given": "Safwat", "initials": "S", "orcid": "0000-0002-3015-5754", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f74cf5c04b1492790e518ae4b161779.json"}}, {"family": "Klingborg", "given": "Leon", "initials": "L", "orcid": "0000-0002-1662-7890", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/17924357598546489de2acc485c0643f.json"}}, {"family": "Herzig van Wees", "given": "Sibylle", "initials": "S", "orcid": "0000-0002-5270-1170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e2480c5cb4545a0a707cf74fb9a6322.json"}}], "type": "journal article", "published": "2023-02-22", "journal": {"title": "JMIR Infodemiology", "issn": "2564-1891", "volume": "3", "pages": "e42357", "issn-l": null}, "abstract": "Social media have played an important role in shaping COVID-19 vaccine choices during the pandemic. Understanding people's attitudes toward the vaccine as expressed on social media can help address the concerns of vaccine-hesitant individuals.\n\nThe aim of this study was to understand the attitudes of Swedish-speaking Twitter users toward COVID-19 vaccines.\n\nThis was an exploratory qualitative study that used a social media-listening approach. Between January and March 2022, a total of 2877 publicly available tweets in Swedish were systematically extracted from Twitter. A deductive thematic analysis was conducted using the World Health Organization's 3C model (confidence, complacency, and convenience).\n\nConfidence in the safety and effectiveness of the COVID-19 vaccine appeared to be a major concern expressed on Twitter. Unclear governmental strategies in managing the pandemic in Sweden and the belief in conspiracy theories have further influenced negative attitudes toward vaccines. Complacency-the perceived risk of COVID-19 was low and booster vaccination was unnecessary; many expressed trust in natural immunity. Convenience-in terms of accessing the right information and the vaccine-highlighted a knowledge gap about the benefits and necessity of the vaccine, as well as complaints about the quality of vaccination services.\n\nSwedish-speaking Twitter users in this study had negative attitudes toward COVID-19 vaccines, particularly booster vaccines. We identified attitudes toward vaccines and misinformation, indicating that social media monitoring can help policy makers respond by developing proactive health communication interventions.", "doi": "10.2196/42357", "pmid": "37012999", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9996415"}, {"db": "pii", "key": "v3i1e42357"}], "notes": [], "created": "2023-04-19T16:41:04.539Z", "modified": "2023-04-20T17:34:37.417Z"}, {"entity": "publication", "iuid": "db6afbf613f94ad1a97b041a9a9acdde", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db6afbf613f94ad1a97b041a9a9acdde.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db6afbf613f94ad1a97b041a9a9acdde"}}, "title": "Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity.", "authors": [{"family": "Yoshiji", "given": "Satoshi", "initials": "S", "orcid": "0000-0001-8863-2413", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b4aff6c38b244e98d3ba65db57c1637.json"}}, {"family": "Butler-Laporte", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-5388-0396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/529dc69151d3463e8480b975d70fa759.json"}}, {"family": "Lu", "given": "Tianyuan", "initials": "T", "orcid": "0000-0002-5664-5698", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e379dceef0244aa7b76f24294f72c537.json"}}, {"family": "Willett", "given": "Julian Daniel Sunday", "initials": "JDS"}, {"family": "Su", "given": "Chen-Yang", "initials": "CY", "orcid": "0000-0001-6071-4660", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cdedd44e2dbd4723893f827517a64732.json"}}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T", "orcid": "0000-0001-9510-5646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd273e50091d44c3b3e8d1473ce89b0a.json"}}, {"family": "Morrison", "given": "David R", "initials": "DR", "orcid": "0000-0001-8380-3615", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6099e7b5999e486eb486bac1f455fdc1.json"}}, {"family": "Chen", "given": "Yiheng", "initials": "Y"}, {"family": "Liang", "given": "Kevin", "initials": "K"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Ilboudo", "given": "Yann", "initials": "Y"}, {"family": "Afrasiabi", "given": "Zaman", "initials": "Z", "orcid": "0000-0003-4395-5168", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/794e813ab12a49b8b92067ae83a0b8bb.json"}}, {"family": "Lan", "given": "Shanshan", "initials": "S"}, {"family": "Duggan", "given": "Naomi", "initials": "N"}, {"family": "DeLuca", "given": "Chantal", "initials": "C"}, {"family": "Vaezi", "given": "Mitra", "initials": "M"}, {"family": "Tselios", "given": "Chris", "initials": "C"}, {"family": "Xue", "given": "Xiaoqing", "initials": "X"}, {"family": "Bouab", "given": "Meriem", "initials": "M"}, {"family": "Shi", "given": "Fangyi", "initials": "F"}, {"family": "Laurent", "given": "Laetitia", "initials": "L"}, {"family": "M\u00fcnter", "given": "Hans Markus", "initials": "HM", "orcid": "0000-0002-3165-2840", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f3f86c18235456688c86013f19703b4.json"}}, {"family": "Afilalo", "given": "Marc", "initials": "M"}, {"family": "Afilalo", "given": "Jonathan", "initials": "J"}, {"family": "Mooser", "given": "Vincent", "initials": "V", "orcid": "0000-0002-8632-0448", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7af40c95aeaf4dd7ab639b31f773b89a.json"}}, {"family": "Timpson", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0002-7141-9189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90b26df69dcd46bd9f6e4eebbf46a36f.json"}}, {"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "Zhou", "given": "Sirui", "initials": "S"}, {"family": "Forgetta", "given": "Vincenzo", "initials": "V"}, {"family": "Farjoun", "given": "Yossi", "initials": "Y"}, {"family": "Richards", "given": "J Brent", "initials": "JB", "orcid": "0000-0002-3746-9086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8994152547ee4765b1653b834c52a21a.json"}}], "type": "journal article", "published": "2023-02-20", "journal": {"title": "Nat Metab", "issn": "2522-5812", "pages": "1-17", "issn-l": null}, "abstract": "Obesity is a major risk factor for Coronavirus disease (COVID-19) severity; however, the mechanisms underlying this relationship are not fully understood. As obesity influences the plasma proteome, we sought to identify circulating proteins mediating the effects of obesity on COVID-19 severity in humans. Here, we screened 4,907 plasma proteins to identify proteins influenced by body mass index using Mendelian randomization. This yielded 1,216 proteins, whose effect on COVID-19 severity was assessed, again using Mendelian randomization. We found that an s.d. increase in nephronectin (NPNT) was associated with increased odds of critically ill COVID-19 (OR = 1.71, P = 1.63 \u00d7 10-10). The effect was driven by an NPNT splice isoform. Mediation analyses supported NPNT as a mediator. In single-cell RNA-sequencing, NPNT was expressed in alveolar cells and fibroblasts of the lung in individuals who died of COVID-19. Finally, decreasing body fat mass and increasing fat-free mass were found to lower NPNT levels. These findings provide actionable insights into how obesity influences COVID-19 severity.", "doi": "10.1038/s42255-023-00742-w", "pmid": "36805566", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC9940690"}, {"db": "pii", "key": "10.1038/s42255-023-00742-w"}], "notes": [], "created": "2023-02-27T17:28:10.291Z", "modified": "2023-02-27T17:28:10.490Z"}, {"entity": "publication", "iuid": "85d25302102c460dae7b0c13bb3014db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/85d25302102c460dae7b0c13bb3014db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/85d25302102c460dae7b0c13bb3014db"}}, "title": "New Presentation of CD27 Deficiency; Coronary Ectasia and COVID-19.", "authors": [{"family": "Golchehre", "given": "Zahra", "initials": "Z"}, {"family": "Sharafian", "given": "Samin", "initials": "S"}, {"family": "Momtazmanesh", "given": "Nader", "initials": "N"}, {"family": "Chavoshzadeh", "given": "Zahra", "initials": "Z"}, {"family": "Karimi", "given": "Abdollah", "initials": "A"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Kazemi Aghdam", "given": "Maryam", "initials": "M"}, {"family": "Vahidshahi", "given": "Koroush", "initials": "K"}, {"family": "Hashemimoghaddam", "given": "Seyedehatefeh", "initials": "S"}, {"family": "Kosari", "given": "Farid", "initials": "F"}, {"family": "Khafafpour", "given": "Zahra", "initials": "Z"}, {"family": "Shamsian", "given": "Bibi Shahin", "initials": "BS"}, {"family": "Keramatipour", "given": "Mohammad", "initials": "M"}], "type": "journal article", "published": "2023-02-20", "journal": {"title": "Iran J Allergy Asthma Immunol", "issn": "1735-5249", "volume": "22", "issue": "1", "pages": "110-118", "issn-l": null}, "abstract": "CD27 is a costimulatory receptor involved in the maturation of the innate and adaptive immunity. CD27, through interaction with CD70, plays a role in the control of Epstein-Barr virus (EBV) infection. CD27 deficiency leads to an immune dysregulation disease characterized by EBV susceptibility. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might put patients with primary immunodeficiency at risk for adverse outcomes. Chromogenic in situ hybridization (CISH) study was performed to detect EBV in the lymphoma tissue. Genetic analysis of the patient was done with Whole Exome Sequencing and detected variant was confirmed with PCR-Sanger sequencing. Here we report a 20-month-old boy with CD27 deficiency who developed lymphoma and coronary artery ectasia and had been infected with SARS-CoV-2. Clinical and laboratory findings were incompatible with atypical Kawasaki syndrome or multisystem inflammatory syndrome in children (MIS-C). As CD27 deficiency is a rare immune defect, publishing clinical data about the identified patient(s) can shed light on our knowledge about the related phenotype and the spectrum of clinical manifestations associated with CD27 deficiency. Thus, our findings expanded the spectrum of manifestations beyond EBV infection, highlighting this unusual cardiac sequela that could be related to EBV infection, lymphoma, or an underlying disease.", "doi": "10.18502/ijaai.v22i1.12013", "pmid": "37002625", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-04-20T17:41:34.380Z", "modified": "2023-04-20T17:41:34.413Z"}, {"entity": "publication", "iuid": "a2e01bfc1523496fb967631f70974504", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2e01bfc1523496fb967631f70974504.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2e01bfc1523496fb967631f70974504"}}, "title": "Lipid Nanoparticles Deliver the Therapeutic VEGFA mRNA In Vitro and In Vivo and Transform Extracellular Vesicles for Their Functional Extensions.", "authors": [{"family": "Nawaz", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-0792-8296", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/371c4ed4410a443299531a5137b3f51d.json"}}, {"family": "Heydarkhan-Hagvall", "given": "Sepideh", "initials": "S"}, {"family": "Tangruksa", "given": "Benyapa", "initials": "B"}, {"family": "Gonz\u00e1lez-King Garibotti", "given": "Hern\u00e1n", "initials": "H"}, {"family": "Jing", "given": "Yujia", "initials": "Y"}, {"family": "Maugeri", "given": "Marco", "initials": "M"}, {"family": "Kohl", "given": "Franziska", "initials": "F"}, {"family": "Hultin", "given": "Leif", "initials": "L"}, {"family": "Reyahi", "given": "Azadeh", "initials": "A"}, {"family": "Camponeschi", "given": "Alessandro", "initials": "A"}, {"family": "Kull", "given": "Bengt", "initials": "B"}, {"family": "Christoffersson", "given": "Jonas", "initials": "J"}, {"family": "Grimsholm", "given": "Ola", "initials": "O", "orcid": "0000-0003-2064-2556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35635778f5ff488a9e74710bea12541e.json"}}, {"family": "Jennbacken", "given": "Karin", "initials": "K"}, {"family": "Sundqvist", "given": "Martina", "initials": "M", "orcid": "0000-0002-0859-0792", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a430c7ad6be440c78357a4c7f3e59a95.json"}}, {"family": "Wiseman", "given": "John", "initials": "J"}, {"family": "Bidar", "given": "Abdel Wahad", "initials": "AW"}, {"family": "Lindfors", "given": "Lennart", "initials": "L"}, {"family": "Synnergren", "given": "Jane", "initials": "J"}, {"family": "Valadi", "given": "Hadi", "initials": "H", "orcid": "0000-0003-3482-2451", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebbd5ef128eb464b969e08d93c050246.json"}}], "type": "journal article", "published": "2023-02-19", "journal": {"title": "Adv. Sci.", "issn": "2198-3844", "pages": "e2206187", "issn-l": null}, "abstract": "Lipid nanoparticles (LNPs) are currently used to transport functional mRNAs, such as COVID-19 mRNA vaccines. The delivery of angiogenic molecules, such as therapeutic VEGF-A mRNA, to ischemic tissues for producing new blood vessels is an emerging strategy for the treatment of cardiovascular diseases. Here, the authors deliver VEGF-A mRNA via LNPs and study stoichiometric quantification of their uptake kinetics and how the transport of exogenous LNP-mRNAs between cells is functionally extended by cells' own vehicles called extracellular vesicles (EVs). The results show that cellular uptake of LNPs and their mRNA molecules occurs quickly, and that the translation of exogenously delivered mRNA begins immediately. Following the VEGF-A mRNA delivery to cells via LNPs, a fraction of internalized VEGF-A mRNA is secreted via EVs. The overexpressed VEGF-A mRNA is detected in EVs secreted from three different cell types. Additionally, RNA-Seq analysis reveals that as cells' response to LNP-VEGF-A mRNA treatment, several overexpressed proangiogenic transcripts are packaged into EVs. EVs are further deployed to deliver VEGF-A mRNA in vitro and in vivo. Upon equal amount of VEGF-A mRNA delivery via three EV types or LNPs in vitro, EVs from cardiac progenitor cells are the most efficient in promoting angiogenesis per amount of VEGF-A protein produced. Intravenous administration of luciferase mRNA shows that EVs could distribute translatable mRNA to different organs with the highest amounts of luciferase detected in the liver. Direct injections of VEGF-A mRNA (via EVs or LNPs) into mice heart result in locally produced VEGF-A protein without spillover to liver and circulation. In addition, EVs from cardiac progenitor cells cause minimal production of inflammatory cytokines in cardiac tissue compared with all other treatment types. Collectively, the data demonstrate that LNPs transform EVs as functional extensions to distribute therapeutic mRNA between cells, where EVs deliver this mRNA differently than LNPs.", "doi": "10.1002/advs.202206187", "pmid": "36806740", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-02-27T17:27:20.630Z", "modified": "2023-02-27T17:27:20.759Z"}, {"entity": "publication", "iuid": "ac1abbf0ce2948ee94e770dabb6574fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac1abbf0ce2948ee94e770dabb6574fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac1abbf0ce2948ee94e770dabb6574fd"}}, "title": "Differential regulation of mRNA stability modulates transcriptional memory and facilitates environmental adaptation.", "authors": [{"family": "Li", "given": "Bingnan", "initials": "B", "orcid": "0000-0001-8143-4035", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53b7a6990ba146c0a6417e5301261b5a.json"}}, {"family": "Zeis", "given": "Patrice", "initials": "P", "orcid": "0000-0001-7615-2201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df9459746cb14785ae7b8dcc8f90a485.json"}}, {"family": "Zhang", "given": "Yujie", "initials": "Y"}, {"family": "Alekseenko", "given": "Alisa", "initials": "A"}, {"family": "F\u00fcrst", "given": "Eliska", "initials": "E", "orcid": "0000-0001-7101-5347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/239337d0862a43e6b8d202b8614db1bc.json"}}, {"family": "Sanchez", "given": "Yerma Pareja", "initials": "YP"}, {"family": "Lin", "given": "Gen", "initials": "G", "orcid": "0000-0001-9969-8418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3e8e9a47be743a9b14048fc342b671b.json"}}, {"family": "Tekkedil", "given": "Manu M", "initials": "MM"}, {"family": "Piazza", "given": "Ilaria", "initials": "I"}, {"family": "Steinmetz", "given": "Lars M", "initials": "LM"}, {"family": "Pelechano", "given": "Vicent", "initials": "V", "orcid": "0000-0002-9415-788X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce53b4c829e547399014c2d8042dde35.json"}}], "type": "journal article", "published": "2023-02-17", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "910", "issn-l": "2041-1723"}, "abstract": "Transcriptional memory, by which cells respond faster to repeated stimuli, is key for cellular adaptation and organism survival. Chromatin organization has been shown to play a role in the faster response of primed cells. However, the contribution of post-transcriptional regulation is not yet explored. Here we perform a genome-wide screen to identify novel factors modulating transcriptional memory in S. cerevisiae in response to galactose. We find that depletion of the nuclear RNA exosome increases GAL1 expression in primed cells. Our work shows that gene-specific differences in intrinsic nuclear surveillance factor association can enhance both gene induction and repression in primed cells. Finally, we show that primed cells present altered levels of RNA degradation machinery and that both nuclear and cytoplasmic mRNA decay modulate transcriptional memory. Our results demonstrate that mRNA post-transcriptional regulation, and not only transcription regulation, should be considered when investigating gene expression memory.", "doi": "10.1038/s41467-023-36586-x", "pmid": "36801853", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC9936472"}, {"db": "pii", "key": "10.1038/s41467-023-36586-x"}], "notes": [], "created": "2023-02-27T17:25:01.083Z", "modified": "2023-06-19T15:33:33.755Z"}, {"entity": "publication", "iuid": "86d2b7403ad64b9f8ca7e607937227c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86d2b7403ad64b9f8ca7e607937227c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86d2b7403ad64b9f8ca7e607937227c0"}}, "title": "Increasing serum iron levels and their role in the risk of infectious diseases: a Mendelian randomization approach.", "authors": [{"family": "Butler-Laporte", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-5388-0396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/529dc69151d3463e8480b975d70fa759.json"}}, {"family": "Farjoun", "given": "Yossi", "initials": "Y"}, {"family": "Chen", "given": "Yiheng", "initials": "Y"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Liang", "given": "Kevin Y H", "initials": "KYH"}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T", "orcid": "0000-0001-9510-5646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd273e50091d44c3b3e8d1473ce89b0a.json"}}, {"family": "Su", "given": "Chen-Yang", "initials": "CY"}, {"family": "Yoshiji", "given": "Satoshi", "initials": "S"}, {"family": "Forgetta", "given": "Vincenzo", "initials": "V", "orcid": "0000-0002-6061-4720", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/347fc19ca94d4a498fc5b04634046425.json"}}, {"family": "Richards", "given": "J Brent", "initials": "JB", "orcid": "0000-0002-3746-9086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8994152547ee4765b1653b834c52a21a.json"}}], "type": "journal article", "published": "2023-02-11", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "issn-l": "0300-5771"}, "abstract": "Increased iron stores have been associated with elevated risks of different infectious diseases, suggesting that iron supplementation may increase the risk of infections. However, these associations may be biased by confounding or reverse causation. This is important, since up to 19% of the population takes iron supplementation. We used Mendelian randomization (MR) to bypass these biases and estimate the causal effect of iron on infections.\n\nAs instrumental variables, we used genetic variants associated with iron biomarkers in two genome-wide association studies (GWASs) of European ancestry participants. For outcomes, we used GWAS results from the UK Biobank, FinnGen, the COVID-19 Host Genetics Initiative or 23andMe, for seven infection phenotypes: 'any infections', combined, COVID-19 hospitalization, candidiasis, pneumonia, sepsis, skin and soft tissue infection (SSTI) and urinary tract infection (UTI).\n\nMost of our analyses showed increasing iron (measured by its biomarkers) was associated with only modest changes in the odds of infectious outcomes, with all 95% odds ratios confidence intervals within the 0.88 to 1.26 range. However, for the three predominantly bacterial infections (sepsis, SSTI, UTI), at least one analysis showed a nominally elevated risk with increased iron stores (P <0.05).\n\nUsing MR, we did not observe an increase in risk of most infectious diseases with increases in iron stores. However for bacterial infections, higher iron stores may increase odds of infections. Hence, using genetic variation in iron pathways as a proxy for iron supplementation, iron supplements are likely safe on a population level, but we should continue the current practice of conservative iron supplementation during bacterial infections or in those at high risk of developing them.", "doi": "10.1093/ije/dyad010", "pmid": "36773317", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "7034613"}], "notes": [], "created": "2023-02-13T17:59:17.506Z", "modified": "2023-02-13T17:59:27.451Z"}, {"entity": "publication", "iuid": "82fdb9dd967b4b5b9838d495f2cb101b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82fdb9dd967b4b5b9838d495f2cb101b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82fdb9dd967b4b5b9838d495f2cb101b"}}, "title": "Antibiotic use during coronavirus disease 2019 intensive care unit shape multidrug resistance bacteriuria: A Swedish longitudinal prospective study.", "authors": [{"family": "Karlsson", "given": "Philip A", "initials": "PA"}, {"family": "P\u00e4rssinen", "given": "Julia", "initials": "J"}, {"family": "Danielsson", "given": "Erik A", "initials": "EA"}, {"family": "Fatsis-Kavalopoulos", "given": "Nikos", "initials": "N"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}, {"family": "Wang", "given": "Helen", "initials": "H"}], "type": "journal article", "published": "2023-02-07", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "10", "pages": "1087446", "issn-l": null}, "abstract": "High frequency of antimicrobial prescription and the nature of prolonged illness in COVID-19 increases risk for complicated bacteriuria and antibiotic resistance. We investigated risk factors for bacteriuria in the ICU and the correlation between antibiotic treatment and persistent bacteria.\n\nWe conducted a prospective longitudinal study with urine from indwelling catheters of 101 ICU patients from Uppsala University Hospital, Sweden. Samples were screened and isolates confirmed with MALDI-TOF and whole genome sequencing. Isolates were analyzed for AMR using broth microdilution. Clinical data were assessed for correlation with bacteriuria.\n\nLength of stay linearly correlated with bacteriuria (R2 = 0.99, p \u2264 0.0001). 90% of patients received antibiotics, primarily the beta-lactams (76%) cefotaxime, piperacillin-tazobactam, and meropenem. We found high prevalence of Enterococcus (42%) being associated with increased cefotaxime prescription. Antibiotic-susceptible E. coli were found to cause bacteriuria despite concurrent antibiotic treatment when found in co-culture with Enterococcus.\n\nLonger stays in ICUs increase the risk for bacteriuria in a predictable manner. Likely, high use of cefotaxime drives Enterococcus prevalence, which in turn permit co-colonizing Gram-negative bacteria. Our results suggest biofilms in urinary catheters as a reservoir of pathogenic bacteria with the potential to develop and disseminate AMR.", "doi": "10.3389/fmed.2023.1087446", "pmid": "36824610", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC9941185"}], "notes": [], "created": "2023-02-27T17:27:48.653Z", "modified": "2023-02-27T17:27:48.666Z"}, {"entity": "publication", "iuid": "a4366a6d02d248b797694c9f9ecf6fab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a4366a6d02d248b797694c9f9ecf6fab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a4366a6d02d248b797694c9f9ecf6fab"}}, "title": "High prevalence of persistent symptoms and reduced health-related quality of life 6 months after COVID-19.", "authors": [{"family": "Ahmad", "given": "Irma", "initials": "I"}, {"family": "Edin", "given": "Alicia", "initials": "A"}, {"family": "Granvik", "given": "Christoffer", "initials": "C"}, {"family": "Kumm Persson", "given": "Lowa", "initials": "L"}, {"family": "Tevell", "given": "Staffan", "initials": "S"}, {"family": "M\u00e5nsson", "given": "Emeli", "initials": "E"}, {"family": "Magnuson", "given": "Anders", "initials": "A"}, {"family": "Marklund", "given": "Ingela", "initials": "I"}, {"family": "Persson", "given": "Ida-Lisa", "initials": "IL"}, {"family": "Kauppi", "given": "Anna", "initials": "A"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Sundh", "given": "Josefin", "initials": "J"}, {"family": "Lange", "given": "Anna", "initials": "A"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "Normark", "given": "Johan", "initials": "J"}], "type": "multicenter study", "published": "2023-02-02", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "11", "pages": "1104267", "issn-l": "2296-2565"}, "abstract": "The long-term sequelae after COVID-19 constitute a challenge to public health and increased knowledge is needed. We investigated the prevalence of self-reported persistent symptoms and reduced health-related quality of life (HRQoL) in relation to functional exercise capacity, 6 months after infection, and explored risk factors for COVID-19 sequalae.\n\nThis was a prospective, multicenter, cohort study including 434 patients. At 6 months, physical exercise capacity was assessed by a 1-minute sit-to-stand test (1MSTST) and persistent symptoms were reported and HRQoL was evaluated through the EuroQol 5-level 5-dimension (EQ-5D-5L) questionnaire. Patients with both persistent symptoms and reduced HRQoL were classified into a new definition of post-acute COVID syndrome, PACS+. Risk factors for developing persistent symptoms, reduced HRQoL and PACS+ were identified by multivariable Poisson regression.\n\nPersistent symptoms were experienced by 79% of hospitalized, and 59% of non-hospitalized patients at 6 months. Hospitalized patients had a higher prevalence of self-assessed reduced overall health (28 vs. 12%) and PACS+ (31 vs. 11%). PACS+ was associated with reduced exercise capacity but not with abnormal pulse/desaturation during 1MSTST. Hospitalization was the most important independent risk factor for developing persistent symptoms, reduced overall health and PACS+.\n\nPersistent symptoms and reduced HRQoL are common among COVID-19 survivors, but abnormal pulse and peripheral saturation during exercise could not distinguish patients with PACS+. Patients with severe infection requiring hospitalization were more likely to develop PACS+, hence these patients should be prioritized for clinical follow-up after COVID-19.", "doi": "10.3389/fpubh.2023.1104267", "pmid": "36817925", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC9932930"}], "notes": [], "created": "2023-02-27T17:23:53.661Z", "modified": "2023-02-27T17:24:00.330Z"}, {"entity": "publication", "iuid": "01f72b147d9c4d46b6734b4cfb0424d3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01f72b147d9c4d46b6734b4cfb0424d3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01f72b147d9c4d46b6734b4cfb0424d3"}}, "title": "Mental health indicators in Sweden over a 12-month period during the COVID-19 pandemic - Baseline data of the Omtanke2020 Study.", "authors": [{"family": "Lovik", "given": "Anik\u00f3", "initials": "A"}, {"family": "Gonz\u00e1lez-Hij\u00f3n", "given": "Juan", "initials": "J"}, {"family": "K\u00e4hler", "given": "Anna K", "initials": "AK"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Frans", "given": "Emma M", "initials": "EM"}, {"family": "Magnusson", "given": "Patrik K E", "initials": "PKE"}, {"family": "Pedersen", "given": "Nancy L", "initials": "NL"}, {"family": "Hall", "given": "Per", "initials": "P"}, {"family": "Czene", "given": "Kamila", "initials": "K"}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF"}, {"family": "Fang", "given": "Fang", "initials": "F"}], "type": "journal article", "published": "2023-02-01", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "volume": "322", "pages": "108-117", "issn-l": null}, "abstract": "The ongoing COVID-19 pandemic has had an unprecedented impact on the lives of people globally and is expected to have profound effects on mental health. Here we aim to describe the mental health burden experienced in Sweden using baseline data of the Omtanke2020 Study.\n\nWe analysed self-reported, cross-sectional baseline data collected over a 12-month period (June 9, 2020-June 8, 2021) from the Omtanke2020 Study including 27,950 adults in Sweden. Participants were volunteers or actively recruited through existing cohorts and, after providing informed consent, responded to online questionnaires on socio-demographics, mental and physical health, as well as COVID-19 infection and impact. Poisson regression was fitted to assess the relative risk of demonstrating high level symptoms of depression, anxiety, and COVID-19 related distress.\n\nThe proportion of persons with high level of symptoms was 15.6 %, 9.5 % and 24.5 % for depression, anxiety, and COVID-19 specific post-traumatic stress disorder (PTSD), respectively. Overall, 43.4 % of the participants had significant, clinically relevant symptoms for at least one of the three mental health outcomes and 7.3 % had significant symptoms for all three outcomes. We also observed differences in the prevalence of these outcomes across strata of sex, age, recruitment type, COVID-19 status, region, and seasonality.\n\nWhile the proportion of persons with high mental health burden remains higher than the ones reported in pre-pandemic publications, our estimates are lower than previously reported levels of depression, anxiety, and PTSD during the pandemic in Sweden and elsewhere.", "doi": "10.1016/j.jad.2022.11.004", "pmid": "36379324", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Preprint": null}, "xrefs": [{"db": "pmc", "key": "PMC9657895"}, {"db": "pii", "key": "S0165-0327(22)01252-6"}], "notes": [], "created": "2022-11-25T07:24:27.748Z", "modified": "2023-02-13T18:39:15.011Z"}, {"entity": "publication", "iuid": "5fc7d1a35d05441280c6096db20c361d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5fc7d1a35d05441280c6096db20c361d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5fc7d1a35d05441280c6096db20c361d"}}, "title": "Clinical outcomes of myocarditis after SARS-CoV-2 mRNA vaccination in four Nordic countries: population based cohort study.", "authors": [{"family": "Husby", "given": "Anders", "initials": "A", "orcid": "0000-0002-7634-8455", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b55ca3663d44e5b9a3b3beec78d5f2f.json"}}, {"family": "Gulseth", "given": "Hanne L\u00f8vdal", "initials": "HL"}, {"family": "Hovi", "given": "Petteri", "initials": "P"}, {"family": "Hansen", "given": "J\u00f8rgen Vinsl\u00f8v", "initials": "JV"}, {"family": "Pihlstr\u00f6m", "given": "Nicklas", "initials": "N"}, {"family": "Gunnes", "given": "Nina", "initials": "N"}, {"family": "H\u00e4rk\u00e4nen", "given": "Tommi", "initials": "T", "orcid": "0000-0002-4577-1808", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d721ae724cf2493ebb2b7f7ee71c7623.json"}}, {"family": "Dahl", "given": "Jesper", "initials": "J"}, {"family": "Karlstad", "given": "\u00d8ystein", "initials": "\u00d8"}, {"family": "Heli\u00f6", "given": "Tiina", "initials": "T"}, {"family": "K\u00f8ber", "given": "Lars", "initials": "L"}, {"family": "Ljung", "given": "Rickard", "initials": "R", "orcid": "0000-0002-0654-4530", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ba40c2b98b1442192811ba44ffbf967.json"}}, {"family": "Hviid", "given": "Anders", "initials": "A", "orcid": "0000-0002-7509-9127", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de7b6744ea454106afe080326be26390.json"}}], "type": "journal article", "published": "2023-02-01", "journal": {"title": "BMJ Med", "issn": "2754-0413", "volume": "2", "issue": "1", "pages": "e000373", "issn-l": null}, "abstract": "To investigate the clinical outcomes of myocarditis associated with mRNA vaccines against the SARS-CoV-2 virus compared with other types of myocarditis.\n\nPopulation based cohort study.\n\nNationwide register data from four Nordic countries (Denmark, Finland, Norway, and Sweden), from 1 January 2018 to the latest date of follow-up in 2022.\n\nThe Nordic myocarditis cohort; 7292 individuals aged \u226512 years who had an incident diagnosis of myocarditis as a main or secondary diagnosis, in a population of 23 million individuals in Denmark, Finland, Norway, and Sweden.\n\nHeart failure, or death from any cause within 90 days of admission to hospital for new onset myocarditis, and hospital readmission within 90 days of discharge to hospital for new onset myocarditis. Clinical outcomes of myocarditis associated with SARS-CoV-2 mRNA vaccination, covid-19 disease, and conventional myocarditis were compared.\n\nIn 2018-22, 7292 patients were admitted to hospital with new onset myocarditis, with 530 (7.3%) categorised as having myocarditis associated with SARS-CoV-2 mRNA vaccination, 109 (1.5%) with myocarditis associated with covid-19 disease, and 6653 (91.2%) with conventional myocarditis. At the 90 day follow-up, 62, nine, and 988 patients had been readmitted to hospital in each group (vaccination, covid-19, and conventional myocarditis groups, respectively), corresponding to a relative risk of readmission of 0.79 (95% confidence interval 0.62 to 1.00) and 0.55 (0.30 to 1.04) for the vaccination type and covid-19 type myocarditis groups, respectively, compared with the conventional myocarditis group. At the 90 day follow-up, 27, 18, and 616 patients had a diagnosis of heart failure or died in the vaccination type, covid-19 type, and conventional myocarditis groups, respectively. The relative risk of heart failure within 90 days was 0.56 (95% confidence interval 0.37 to 0.85) and 1.48 (0.86 to 2.54) for myocarditis associated with vaccination and covid-19 disease, respectively, compared with conventional myocarditis; the relative risk of death was 0.48 (0.21 to 1.09) and 2.35 (1.06 to 5.19), respectively. Among patients aged 12-39 years with no predisposing comorbidities, the relative risk of heart failure or death was markedly higher for myocarditis associated with covid-19 disease than for myocarditis associated with vaccination (relative risk 5.78, 1.84 to 18.20).\n\nCompared with myocarditis associated with covid-19 disease and conventional myocarditis, myocarditis after vaccination with SARS-CoV-2 mRNA vaccines was associated with better clinical outcomes within 90 days of admission to hospital.", "doi": "10.1136/bmjmed-2022-000373", "pmid": "36936260", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC9978676"}, {"db": "pii", "key": "bmjmed-2022-000373"}], "notes": [], "created": "2023-04-21T16:10:46.840Z", "modified": "2023-04-21T16:10:46.998Z"}, {"entity": "publication", "iuid": "b504cb171e774762b6d6e809b24fa3da", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b504cb171e774762b6d6e809b24fa3da.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b504cb171e774762b6d6e809b24fa3da"}}, "title": "ThermalProGAN: A sequence-based thermally stable protein generator trained using unpaired data.", "authors": [{"family": "Huang", "given": "Hui-Ling", "initials": "HL"}, {"family": "Weng", "given": "Chong-Heng", "initials": "CH"}, {"family": "Nordling", "given": "Torbj\u00f6rn E M", "initials": "TEM"}, {"family": "Liou", "given": "Yi-Fan", "initials": "YF"}], "type": "journal article", "published": "2023-02-00", "journal": {"title": "J Bioinform Comput Biol", "issn": "1757-6334", "volume": "21", "issue": "1", "pages": "2350008", "issn-l": null}, "abstract": "The synthesis of proteins with novel desired properties is challenging but sought after by the industry and academia. The dominating approach is based on trial-and-error inducing point mutations, assisted by structural information or predictive models built with paired data that are difficult to collect. This study proposes a sequence-based unpaired-sample of novel protein inventor (SUNI) to build ThermalProGAN for generating thermally stable proteins based on sequence information.\n\nThe ThermalProGAN can strongly mutate the input sequence with a median number of 32 residues. A known normal protein, 1RG0, was used to generate a thermally stable form by mutating 51 residues. After superimposing the two structures, high similarity is shown, indicating that the basic function would be conserved. Eighty four molecular dynamics simulation results of 1RG0 and the COVID-19 vaccine candidates with a total simulation time of 840[Formula: see text]ns indicate that the thermal stability increased.\n\nThis proof of concept demonstrated that transfer of a desired protein property from one set of proteins is feasible. Availability and implementation: The source code of ThermalProGAN can be freely accessed at https://github.com/markliou/ThermalProGAN/ with an MIT license. The website is https://thermalprogan.markliou.tw:433. Supplementary information: Supplementary data are available on Github.", "doi": "10.1142/S0219720023500087", "pmid": "36999645", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-04-21T15:50:15.045Z", "modified": "2023-04-21T15:50:15.092Z"}, {"entity": "publication", "iuid": "fdb6539aac004b4c8217f99ec69a600e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fdb6539aac004b4c8217f99ec69a600e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fdb6539aac004b4c8217f99ec69a600e"}}, "title": "The impact of COVID-19 and COVID vaccination on cardiovascular outcomes.", "authors": [{"family": "Akhtar", "given": "Zubair", "initials": "Z"}, {"family": "Trent", "given": "Mallory", "initials": "M"}, {"family": "Moa", "given": "Aye", "initials": "A"}, {"family": "Tan", "given": "Timothy C", "initials": "TC"}, {"family": "Fr\u00f6bert", "given": "Ole", "initials": "O"}, {"family": "MacIntyre", "given": "C Raina", "initials": "CR", "orcid": "0000-0002-3060-0555", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/283c1daa61384999861ce474d0678572.json"}}], "type": "journal article", "published": "2023-02-00", "journal": {"title": "Eur Heart J Suppl", "issn": "1520-765X", "volume": "25", "issue": "Suppl A", "pages": "A42-A49", "issn-l": null}, "abstract": "COVID-19 is an independent risk factor for cardiovascular disease. COVID-19 vaccination may prevent this, but in some cases, COVID-19 vaccination may cause myocarditis or pericarditis. Patients with COVID-19 may present with non-specific symptoms that have a cardiac origin. This review examines the cardiovascular complications of COVID-19 infection and the impact of COVID-19 vaccination. COVID-19 cardiovascular complications include myocardial injury, pericarditis, coagulopathy, myocardial infarction, heart failure, arrhythmias, and persistent post-acute risk of adverse cardiovascular outcomes. Diagnostic and referral pathways for non-specific symptoms, such as dyspnoea and fatigue, remain unclear. COVID-19 vaccination is cardioprotective overall but is associated with myopericarditis in young males, though at a lower rate than following SARS-CoV-2 infection. Increased awareness among primary care physicians of potential cardiovascular causes of non-specific post-COVID-19 symptoms, including in younger adults, such as fatigue, dyspnoea, and chest pain, is essential. We recommend full vaccination with scheduled booster doses, optimal management of cardiovascular risk factors, rapid treatment of COVID-19, and clear diagnostic, referral, and management pathways for patients presenting with non-specific symptoms to rule out cardiac complications.", "doi": "10.1093/eurheartjsupp/suac123", "pmid": "36937372", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC10021497"}, {"db": "pii", "key": "suac123"}], "notes": [], "created": "2023-04-21T16:10:28.105Z", "modified": "2023-04-21T16:10:28.161Z"}, {"entity": "publication", "iuid": "98cff7fe9a404ee19184f6f767404caf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/98cff7fe9a404ee19184f6f767404caf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/98cff7fe9a404ee19184f6f767404caf"}}, "title": "SARS-CoV-2 spike HexaPro formulated in aluminium hydroxide and administered in an accelerated vaccination schedule partially protects Syrian Hamsters against viral challenge despite low neutralizing antibody responses.", "authors": [{"family": "Christensen", "given": "Dennis", "initials": "D"}, {"family": "Polacek", "given": "Charlotta", "initials": "C"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Hartmann", "given": "Katrine Top", "initials": "KT"}, {"family": "Jensen", "given": "Henrik Elvang", "initials": "HE"}, {"family": "Zimmermann", "given": "Julie", "initials": "J"}, {"family": "Jungersen", "given": "Gregers", "initials": "G"}, {"family": "Illigen", "given": "Kristin Engelhart", "initials": "KE"}, {"family": "Isling", "given": "Louise Krag", "initials": "LK"}, {"family": "Fernandez-Antunez", "given": "Carlota", "initials": "C"}, {"family": "Ramirez", "given": "Santseharay", "initials": "S"}, {"family": "Bukh", "given": "Jens", "initials": "J"}, {"family": "Pedersen", "given": "Gabriel Kristian", "initials": "GK"}], "type": "journal article", "published": "2023-01-23", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "14", "issue": null, "pages": "941281"}, "abstract": "SARS-CoV-2 continues to pose a threat to human health as new variants emerge and thus a diverse vaccine pipeline is needed. We evaluated SARS-CoV-2 HexaPro spike protein formulated in Alhydrogel\u00ae (aluminium oxyhydroxide) in Syrian hamsters, using an accelerated two dose regimen (given 10 days apart) and a standard regimen (two doses given 21 days apart). Both regimens elicited spike- and RBD-specific IgG antibody responses of similar magnitude, but in vitro virus neutralization was low or undetectable. Despite this, the accelerated two dose regimen offered reduction in viral load and protected against lung pathology upon challenge with homologous SARS-CoV-2 virus (Wuhan-Hu-1). This highlights that vaccine-induced protection against SARS-CoV-2 disease can be obtained despite low neutralizing antibody levels and suggests that accelerated vaccine schedules may be used to confer rapid protection against SARS-CoV-2 disease.", "doi": "10.3389/fimmu.2023.941281", "pmid": "36756130", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Funder: H2020": null}, "xrefs": [{"db": "pmc", "key": "PMC9900178"}, {"db": "URL", "key": "https://www.frontiersin.org/articles/10.3389/fimmu.2023.941281/full#supplementary-material", "description": "https://www.frontiersin.org/articles/10.3389/fimmu.2023.941281/full#supplementary-material"}], "notes": [], "created": "2023-02-13T17:53:06.820Z", "modified": "2023-02-13T17:54:54.510Z"}, {"entity": "publication", "iuid": "6263ba1c3fc449cf85ef048c256bf1b8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6263ba1c3fc449cf85ef048c256bf1b8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6263ba1c3fc449cf85ef048c256bf1b8"}}, "title": "Unravelling the link between sleep and mental health during the COVID-19 pandemic.", "authors": [{"family": "Gonz\u00e1lez-Hij\u00f3n", "given": "Juan", "initials": "J"}, {"family": "K\u00e4hler", "given": "Anna K", "initials": "AK"}, {"family": "Frans", "given": "Emma M", "initials": "EM"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Lovik", "given": "Anik\u00f3", "initials": "A", "orcid": "0000-0002-6397-5011", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e50d5a79a1234cd79b22ec2eebf6f410.json"}}], "type": "journal article", "published": "2023-01-17", "journal": {"title": "Stress Health", "issn": "1532-2998", "issn-l": null}, "abstract": "The emergence of COVID-19 brought unparalleled changes in people's lifestyle, including sleep. We aimed to assess the bidirectional association between sleep quality and mental health and describe how sleep and mental health were affected in Sweden during the COVID-19 pandemic (between June 2020 and September 2021). Data were obtained from the Omtanke2020 study. Participants who completed the baseline survey and each of the 8 monthly follow-up surveys were included (N = 9035). We described the distribution of sleep and mental health in the different Swedish regions using maps and over the study period with longitudinal graphs adjusting for sex, age, recruitment type (self-recruitment or invitation), and COVID-19 status. The inner relationships between mental health, sleep and Covid infection were described through relative importance networks. Finally, we modelled how mental health affects sleep and vice versa using generalized estimating equations with different adjustments. Seasonal and north-south regional variations were found in sleep and mental health outcomes at baseline and attenuated over time. The seasonal variation of sleep and mental health correlated moderately with the incidence rate of COVID-19 in the sample. Networks indicate that the relationship between COVID-19 incidence and mental health varies over time. We observed a bidirectional relationship between sleep quality and quantity at baseline and mental health at follow-up and vice versa. Sleep quality and quantity at baseline was associated with adverse symptom trajectories of mental health at follow-up, and vice versa, during the COVID-19 pandemic. There was also a weak relationship between COVID-19 incidence, sleep, and mental health.", "doi": "10.1002/smi.3223", "pmid": "36649144", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2023-02-13T18:38:35.800Z", "modified": "2023-02-13T18:38:35.856Z"}, {"entity": "publication", "iuid": "13722195d5c8437dbbf2df53eb0ded2e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13722195d5c8437dbbf2df53eb0ded2e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13722195d5c8437dbbf2df53eb0ded2e"}}, "title": "How Sweden approached the COVID-19 pandemic: Summary and commentary on the National Commission Inquiry.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF", "orcid": "0000-0003-1024-5602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1d5e45881a7469ca20a0eb360d891cc.json"}}], "type": "journal article", "published": "2023-01-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": "112", "issue": "1", "pages": "19-33", "issn-l": "0803-5253"}, "abstract": "Sweden initially chose a different disease prevention and control path during the pandemic than many other European countries. In June 2020, the Swedish Government established a National Commission to examine the management of COVID-19 in Sweden. This paper summarises, and discusses, its findings.\n\nThree reports published by the Commission were analysed. The first focused on the care of older people during the pandemic. The second examined disease and infection transmission and control and health care and public health. The third updated the first two reports and also covered economic aspects, crisis management and public communication.\n\nBy 25 February 2022, when the final report was published, 15 800 individuals, 1.5 per 1000 Swedish inhabitants, had died after COVID-19. The death rates were high in spring 2020, but overall excess mortality in 2020-2021 was +0.79%, which was lower than in many other European countries. The Commission suggested that the voluntary measures that were adopted were appropriate and maintained Swedes' personal freedom during the pandemic. However, more extensive and earlier measures should have been taken, especially during the first wave.\n\nThe Swedish COVID-19 Commission felt that earlier and more extensive pandemic action should have been taken, particularly during the first wave.", "doi": "10.1111/apa.16535", "pmid": "36065136", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC9538368"}], "notes": [], "created": "2023-01-13T13:25:04.669Z", "modified": "2023-07-13T11:27:39.751Z"}, {"entity": "publication", "iuid": "c407248f73de4d6e942cd708071d48be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c407248f73de4d6e942cd708071d48be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c407248f73de4d6e942cd708071d48be"}}, "title": "Specific Physiotherapy for Persons in the Post-Acute Phase after Moderate-To-Severe COVID-19: An Experimental Multiple-Baseline Single-Case Study", "authors": [{"family": "Azzabi", "given": "Susann", "initials": "S"}, {"family": "Jones", "given": "Christine", "initials": "C"}, {"family": "S\u00f6derlund", "given": "Anne", "initials": "A"}, {"family": "Nordgren", "given": "Lena", "initials": "L"}], "type": "posted-content", "published": "2023-00-00", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.2139/ssrn.4441260", "pmid": null, "labels": {"Category: Social Science & Humanities": null, "Type: Preprint": null, "Category: Rehabilitation": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:09:58.825Z", "modified": "2023-10-04T06:27:31.281Z"}, {"entity": "publication", "iuid": "a389b5e780ef4cd6b27bcd9c402dd4b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a389b5e780ef4cd6b27bcd9c402dd4b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a389b5e780ef4cd6b27bcd9c402dd4b9"}}, "title": "Mortality in Norway and Sweden During the COVID-19 Pandemic 2020 \u2013 22: A Comparative Study", "authors": [{"family": "Zahl", "given": "Per Henrik", "initials": "PH"}, {"family": "Hemstr\u00f6m", "given": "\u00d6rjan", "initials": "\u00d6"}, {"family": "Johansen", "given": "Rune", "initials": "R"}, {"family": "Mamalund", "given": "Svenn Erik", "initials": "SE"}], "type": "posted-content", "published": "2023-00-00", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.2139/ssrn.4449686", "pmid": null, "labels": {"Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2023-10-04T05:08:36.783Z", "modified": "2023-10-04T05:16:03.167Z"}, {"entity": "publication", "iuid": "2d56c9b15d764223911a21487cb759e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d56c9b15d764223911a21487cb759e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d56c9b15d764223911a21487cb759e2"}}, "title": "Mitigating Oil Price Volatility Amidst the COVID-19 Pandemic: Leveraging Metal Hedging Strategies with Market Uncertainty", "authors": [{"family": "Hussain", "given": "Saddam", "initials": "S"}, {"family": "Hussain", "given": "Sajid", "initials": "S"}], "type": "posted-content", "published": "2023-00-00", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.2139/ssrn.4515282", "pmid": null, "labels": {"Type: Preprint": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:09:37.410Z", "modified": "2023-10-04T12:59:12.155Z"}, {"entity": "publication", "iuid": "58ba0c3206a0408790805f45ada75fc7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/58ba0c3206a0408790805f45ada75fc7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/58ba0c3206a0408790805f45ada75fc7"}}, "title": "Differential Immunometabolism and Tissue Responses to Delta and Omicron SARS-CoV-2 Variants in Golden Syrian Hamster Models", "authors": [{"family": "Rajaiah", "given": "Rajesh", "initials": "R"}, {"family": "Pandey", "given": "Kabita", "initials": "K"}, {"family": "Ambikan", "given": "Anoop T", "initials": "AT"}, {"family": "Kumar", "given": "Narendra", "initials": "N"}, {"family": "Guda", "given": "Reema", "initials": "R"}, {"family": "Montaner", "given": "Luis", "initials": "L"}, {"family": "Cohen", "given": "Samuel M", "initials": "SM"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}, {"family": "Byrareddy", "given": "Siddappa", "initials": "S"}], "type": "posted-content", "published": "2023-00-00", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.2139/ssrn.4554600", "pmid": null, "labels": {"Type: Preprint": null, "Category: Other": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2023-10-06T06:55:21.475Z", "modified": "2023-10-06T10:51:17.531Z"}, {"entity": "publication", "iuid": "e251a5b1eb9c4da29ae1ac53e88d79d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e251a5b1eb9c4da29ae1ac53e88d79d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e251a5b1eb9c4da29ae1ac53e88d79d5"}}, "title": "Dexamethasone Treatment for COVID-19 is Related with Increased Mortality in Haematological Malignancy Patients: Results from the EPICOVIDEHA Registry", "authors": [{"family": "Aiello", "given": "Tommaso Francesco", "initials": "TF"}, {"family": "Salmanton-Garcia", "given": "Jon", "initials": "J"}, {"family": "Marchesi", "given": "Francesco", "initials": "F"}, {"family": "Weinbergerova", "given": "Barbora", "initials": "B"}, {"family": "Glenthoj", "given": "Andreas", "initials": "A"}, {"family": "Van Praet", "given": "Jens", "initials": "J"}, {"family": "Farina", "given": "Francesca", "initials": "F"}, {"family": "Davila-Valls", "given": "Julio", "initials": "J"}, {"family": "Mart\u00edn-P\u00e9rez", "given": "Sonia", "initials": "S"}, {"family": "El-Ashwah", "given": "Shaimaa", "initials": "S"}, {"family": "Sch\u00f6nlein", "given": "Martin", "initials": "M"}, {"family": "Falces-Romero", "given": "Iker", "initials": "I"}, {"family": "Labrador", "given": "Jorge", "initials": "J"}, {"family": "Sili", "given": "Uluhan", "initials": "U"}, {"family": "Buquicchio", "given": "Caterina", "initials": "C"}, {"family": "Vena", "given": "Antonio", "initials": "A"}, {"family": "Plantefeve", "given": "Gaetan", "initials": "G"}, {"family": "Petzer", "given": "Verena", "initials": "V"}, {"family": "Biernat", "given": "Monika M", "initials": "MM"}, {"family": "Lahmer", "given": "Tobias", "initials": "T"}, {"family": "Espigado", "given": "Ildefonso", "initials": "I"}, {"family": "van Doesum", "given": "Jaap A", "initials": "JA"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Piukovics", "given": "Kl\u00e1ra", "initials": "K"}, {"family": "Tascini", "given": "Carlo", "initials": "C"}, {"family": "Samarkos", "given": "Michael", "initials": "M"}, {"family": "Bilgin", "given": "Yavuz M", "initials": "YM"}, {"family": "Fianchi", "given": "Luana", "initials": "L"}, {"family": "Itri", "given": "Federico", "initials": "F"}, {"family": "Valkovic", "given": "Toni", "initials": "T"}, {"family": "Fracchiolla", "given": "Nicola S", "initials": "NS"}, {"family": "Dargenio", "given": "Michelina", "initials": "M"}, {"family": "Jimenez", "given": "Moraima", "initials": "M"}, {"family": "Magyari", "given": "Ferenc", "initials": "F"}, {"family": "Lopez-Garcia", "given": "Alberto", "initials": "A"}, {"family": "Prezioso", "given": "Lucia", "initials": "L"}, {"family": "\u010colovic", "given": "Natasa", "initials": "N"}, {"family": "Shumilov", "given": "Evgenii", "initials": "E"}, {"family": "Abu-Zeinah", "given": "Ghaith", "initials": "G"}, {"family": "Lavilla-Rubira", "given": "Esperanza", "initials": "E"}, {"family": "Papa", "given": "Mario Virgilio", "initials": "MV"}, {"family": "Lopez-Gonzalez", "given": "Tom\u00e1s Jos\u00e9", "initials": "TJ"}, {"family": "Pinczes", "given": "L\u00e1szl\u00f3 Imre", "initials": "LI"}, {"family": "Demirkan", "given": "Fatih", "initials": "F"}, {"family": "Ali", "given": "Natasha", "initials": "N"}, {"family": "Besson", "given": "Caroline", "initials": "C"}, {"family": "Fouquet", "given": "Guillemette", "initials": "G"}, {"family": "Romano", "given": "Alessandra", "initials": "A"}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jose Angel", "initials": "JA"}, {"family": "del Principe", "given": "Maria Ilaria", "initials": "MI"}, {"family": "Aujayeb", "given": "Avinash", "initials": "A"}, {"family": "Merelli", "given": "Maria", "initials": "M"}, {"family": "Lamure", "given": "Sylvain", "initials": "S"}, {"family": "Marques De Almeida", "given": "Joyce", "initials": "J"}, {"family": "Gomes da Silva", "given": "Maria", "initials": "M"}, {"family": "Eisa", "given": "Noha", "initials": "N"}, {"family": "Meletiadis", "given": "Joseph", "initials": "J"}, {"family": "Rinaldi", "given": "Ikhwan", "initials": "I"}, {"family": "Finizio", "given": "Olimpia", "initials": "O"}, {"family": "Jak\u0161i\u0107", "given": "Ozren", "initials": "O"}, {"family": "Delia", "given": "Mario", "initials": "M"}, {"family": "Nizamuddin", "given": "Summiya", "initials": "S"}, {"family": "Marchetti", "given": "Monia", "initials": "M"}, {"family": "Machado", "given": "Marina", "initials": "M"}, {"family": "Cernan", "given": "Martin", "initials": "M"}, {"family": "Coppola", "given": "Nicola", "initials": "N"}, {"family": "Gavriilaki", "given": "Eleni", "initials": "E"}, {"family": "Cattaneo", "given": "Chiara", "initials": "C"}, {"family": "Groh", "given": "Ana", "initials": "A"}, {"family": "Stojanoski", "given": "Zlate", "initials": "Z"}, {"family": "Erben", "given": "Nurettin", "initials": "N"}, {"family": "Pantic", "given": "Nikola", "initials": "N"}, {"family": "Mendez", "given": "Gustavo Adolfo", "initials": "GA"}, {"family": "Di Blasi", "given": "Roberta", "initials": "R"}, {"family": "Meers", "given": "Stef", "initials": "S"}, {"family": "De Ramon", "given": "Cristina", "initials": "C"}, {"family": "Bahr", "given": "Nathan C", "initials": "NC"}, {"family": "Emarah", "given": "Ziad", "initials": "Z"}, {"family": "Varricchio", "given": "Gina", "initials": "G"}, {"family": "Cvetanoski", "given": "Milche", "initials": "M"}, {"family": "Garcia-Sanz", "given": "Ram\u00f3n", "initials": "R"}, {"family": "Mitrovic", "given": "Mirjana", "initials": "M"}, {"family": "Lievin", "given": "Rapha\u00ebl", "initials": "R"}, {"family": "Hanakova", "given": "Michaela", "initials": "M"}, {"family": "Racil", "given": "Zden\u011bk", "initials": "Z"}, {"family": "Vehreschild", "given": "Maria", "initials": "M"}, {"family": "Tragiannidis", "given": "Athanasios", "initials": "A"}, {"family": "Nunes Rodrigues", "given": "Raquel", "initials": "R"}, {"family": "Garcia-Bordallo", "given": "Daniel", "initials": "D"}, {"family": "Cordoba", "given": "Raul", "initials": "R"}, {"family": "Cabirta", "given": "Alba", "initials": "A"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Ammatuna", "given": "Emanuele", "initials": "E"}, {"family": "Arellano", "given": "Elena", "initials": "E"}, {"family": "Wolf", "given": "Dominik", "initials": "D"}, {"family": "Prin", "given": "Romane", "initials": "R"}, {"family": "Limongelli", "given": "Alessandro", "initials": "A"}, {"family": "Bavastro", "given": "Martina", "initials": "M"}, {"family": "\u00c7olak", "given": "G\u00f6k\u00e7e Melis", "initials": "GM"}, {"family": "Grafe", "given": "Stefanie K", "initials": "SK"}, {"family": "Hersby", "given": "Ditte Stampe", "initials": "DS"}, {"family": "Rahimli", "given": "Laman", "initials": "L"}, {"family": "Cornely", "given": "Oliver A", "initials": "OA"}, {"family": "Garcia-Vidal", "given": "Carolina", "initials": "C"}, {"family": "Pagano", "given": "Livio", "initials": "L"}], "type": "posted-content", "published": "2023-00-00", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.2139/ssrn.4473151", "pmid": null, "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-10-04T09:31:55.616Z", "modified": "2023-10-04T10:58:26.841Z"}, {"entity": "publication", "iuid": "2984715e091b41cca10d0afc09010d9d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2984715e091b41cca10d0afc09010d9d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2984715e091b41cca10d0afc09010d9d"}}, "title": "Critical Flows Throughout the Covid-19 Pandemic \u2013 a Longitudinal Study on Interdependencies and Resilience in a Swedish Context", "authors": [{"family": "Lindstr\u00f6m M\u00e5nefjord", "given": "Josefin", "initials": "J"}, {"family": "Johansson", "given": "Jonas", "initials": "J"}], "type": "posted-content", "published": "2023-00-00", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.2139/ssrn.4510064", "pmid": null, "labels": {"Category: Other": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2023-10-04T12:09:32.247Z", "modified": "2023-10-04T12:56:33.856Z"}, {"entity": "publication", "iuid": "44df84b7a2b14cd399c660a2dcc50182", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44df84b7a2b14cd399c660a2dcc50182.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44df84b7a2b14cd399c660a2dcc50182"}}, "title": "Morphological changes without histological myocarditis in hearts of COVID-19 deceased patients", "authors": [{"family": "Razaghi", "given": "Ali", "initials": "A"}, {"family": "Szakos", "given": "Attila", "initials": "A"}, {"family": "Al-Shakarji", "given": "Riham", "initials": "R"}, {"family": "Bj\u00f6rnstedt", "given": "Mikael", "initials": "M"}, {"family": "Szekely", "given": "Laszlo", "initials": "L"}], "type": "journal-article", "published": "2022-12-31", "journal": {"title": "Scandinavian Cardiovascular Journal", "issn": "1401-7431", "volume": "56", "issue": "1", "pages": "166-173", "issn-l": null}, "abstract": "Objective. Patients with underlying heart diseases have a higher risk of dying from Covid-19. It has also been suggested that Covid-19 affects the heart through myocarditis. Despite the rapidly growing research on the management of Covid-19 associated complications, most of the ongoing research is focused on the respiratory complications of Covid-19, and little is known about the prevalence of myocarditis. Design. This study aimed to characterize myocardial involvement by using a panel of antibodies to detect hypoxic and inflammatory changes and the presence of SARS-CoV-2 proteins in heart tissues obtained during the autopsy procedure of Covid-19 deceased patients. Thirty-seven fatal COVID-19 cases and 21 controls were included in this study. Results. Overall, the Covid-19 hearts had several histopathological changes like the waviness of myocytes, fibrosis, contract band necrosis, infiltration of polymorphonuclear neutrophils, vacuolization, and necrosis of myocytes. In addition, endothelial damage and activation were detected in heart tissue. However, viral replication was not detected using RNA in situ hybridization. Also, lymphocyte infiltration, as a hallmark of myocarditis, was not seen in this study. Conclusion. No histological sign of myocarditis was detected in any of our cases; our findings are thus most congruent with the hypothesis of the presence of a circulating endothelium activating factor such as VEGF, originating outside of the heart, probably from the hypoxic part of the Covid-19 lungs.", "doi": "10.1080/14017431.2022.2085320", "pmid": "35678649", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-20T19:29:44.814Z", "modified": "2022-08-19T06:01:01.560Z"}, {"entity": "publication", "iuid": "91d6e059b7e14aab921dec6d04124589", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/91d6e059b7e14aab921dec6d04124589.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/91d6e059b7e14aab921dec6d04124589"}}, "title": "Burden of vaccine-preventable diseases, trends in vaccine coverage and current challenges in the implementation of the expanded program on immunization: A situation analysis of Cameroon.", "authors": [{"family": "Ngwa", "given": "Che Henry", "initials": "CH", "orcid": "0000-0003-1984-7909", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/994a7153e4de4496ace403a940cb7fb5.json"}}, {"family": "Doungtsop", "given": "Brigitte-Carole Keumatio", "initials": "BK"}, {"family": "Bihnwi", "given": "Rengerline", "initials": "R"}, {"family": "Ngo", "given": "Ngo Valery", "initials": "NV"}, {"family": "Yang", "given": "Niendum Mediatrice", "initials": "NM"}], "type": "journal article", "published": "2022-12-31", "journal": {"title": "Hum Vaccin Immunother", "issn": "2164-554X", "issn-l": null, "volume": "18", "issue": "1", "pages": "1939620"}, "abstract": "The discovery and development of vaccines remain one of the major successes of global health with millions of lives saved every year through routine vaccination. Although vaccines provide a safe and cost-effective solution to vaccine-preventable diseases (VPDs), VPDs are still a serious public health problem in most parts of the world, especially in sub-Saharan Africa (SSA) and Asia. In this review, we discuss the burden of VPDs and vaccine coverage several decades after the introduction of the Expanded Program on Immunization (EPI) in Cameroon. We also discuss how different factors affect the implementation of the EPI, highlighting context-specific factors such as the ongoing civil conflict in Cameroon, and the presence of other infectious diseases like COVID-19.", "doi": "10.1080/21645515.2021.1939620", "pmid": "34197271", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8920166"}], "notes": [], "created": "2021-07-05T14:32:04.699Z", "modified": "2023-06-19T15:16:12.262Z"}, {"entity": "publication", "iuid": "1ffb34167f6b46bdb4027e74167a09c7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ffb34167f6b46bdb4027e74167a09c7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ffb34167f6b46bdb4027e74167a09c7"}}, "title": "Sweden's Pandemic Experiment", "authors": [{"family": "Bergmans", "given": "S", "initials": "S"}, {"family": "Lindstr\u00f6m", "given": "M", "initials": "M"}], "type": null, "published": "2022-12-19", "journal": {"title": null, "issn": "ISBN 9781032266718", "issn-l": null, "volume": null, "issue": null, "pages": "322"}, "abstract": "This book considers Sweden\u2019s pandemic management which differed so significantly from much of the rest of the world: it provoked intense and wide-reaching interest, curiosity and criticism. Trans-disciplinary Swedish authors from the humanities, life sciences, social sciences, and cultural studies use a variety of tools to mine deeper into some of the central elements and dimensions in their country\u2019s pandemic management such as understandings of freedom, the execution of power, denialism, exceptionalism, patriotism, the role of expertise and trust in the national state to give a deeper understanding of Sweden\u2019s decisions, failures, successes, and the lessons to be learned.\r\nAimed at readers with interest in global health and politics it will also be of interest in disciplines such as virology,epidemiology, history, cultural studies, ethics, media studies, medicine and economics.\r\nThe Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives.", "doi": "https://doi.org/10.4324/9781003289364", "pmid": null, "labels": {"Type: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2023-01-16T15:35:40.815Z", "modified": "2023-02-23T06:16:16.600Z"}, {"entity": "publication", "iuid": "3bbafb7e92c0416d8fb72a56545e31c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3bbafb7e92c0416d8fb72a56545e31c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3bbafb7e92c0416d8fb72a56545e31c5"}}, "title": "Re-evaluating Our Knowledge of Health System Resilience During COVID-19: Lessons From the First Two Years of the Pandemic.", "authors": [{"family": "Saulnier", "given": "Dell D", "initials": "DD", "orcid": "0000-0001-7761-0737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d3fc961101845b1ae844339af7495e4.json"}}, {"family": "Duchenko", "given": "Anna", "initials": "A"}, {"family": "Ottilie-Kovelman", "given": "Sierra", "initials": "S"}, {"family": "Tediosi", "given": "Fabrizio", "initials": "F", "orcid": "0000-0001-8671-9400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9884188f9c04312b05212ade939818d.json"}}, {"family": "Blanchet", "given": "Karl", "initials": "K", "orcid": "0000-0003-0498-8020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aad004843f3f44c8b011feedf86831e1.json"}}], "type": "review", "published": "2022-12-06", "journal": {"title": "Int J Health Policy Manag", "issn": "2322-5939", "issn-l": null, "volume": "12", "issue": null, "pages": "6659"}, "abstract": "Health challenges like coronavirus disease 2019 (COVID-19) are becoming increasingly complex, transnational, and unpredictable. Studying health system responses to the COVID-19 pandemic is an opportunity to enhance our understanding of health system resilience and establish a clearer link between theoretical concepts and practical ideas on how to build resilience.\r\n\r\nThis narrative literature review aims to address four questions using a health system resilience framework: (i) What do we understand about the dimensions of resilience? (ii) What aspects of the resilience dimensions remain uncertain? (iii) What aspects of the resilience dimensions are missing from the COVID-19 discussions? and (iv) What has COVID-19 taught us about resilience that is missing from the framework? A scientific literature database search was conducted in December 2020 and in April 2022 to identify publications that discussed health system resilience in relation to COVID-19, excluding articles on psychological and other types of resilience. A total of 63 publications were included.\r\n\r\nThere is good understanding around information sharing, flexibility and good leadership, learning, maintaining essential services, and the need for legitimate, interdependent systems. Decision-making, localized trust, influences on interdependence, and transformation remain uncertain. Vertical interdependence, monitoring risks beyond the health system, and consequences of changes on the system were not discussed. Teamwork, actor legitimacy, values, inclusivity, trans-sectoral resilience, and the role of the private sector are identified as lessons from COVID-19 that should be further explored for health system resilience.\r\n\r\nKnowledge of health system resilience has continued to cohere following the pandemic. The eventual consequences of system changes and the resilience of subsystems are underexplored. Through governance, the concept of health system resilience can be linked to wider issues raised by the pandemic, like inclusivity. Our findings show the utility of resilience theory for strengthening health systems for crises and the benefit of continuing to refine existing resilience theory.", "doi": "10.34172/ijhpm.2022.6659", "pmid": "37579465", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC10125099"}, {"db": "pii", "key": "6659"}], "notes": [], "created": "2023-10-05T08:26:23.977Z", "modified": "2023-10-06T04:58:17.047Z"}, {"entity": "publication", "iuid": "b3e56804818b4607b3846fdce98963cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b3e56804818b4607b3846fdce98963cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b3e56804818b4607b3846fdce98963cc"}}, "title": "Effectiveness of COVID-19 Vaccines over 13 Months Covering the Period of the Emergence of the Omicron Variant in the Swedish Population.", "authors": [{"family": "Xu", "given": "Yiyi", "initials": "Y", "orcid": "0000-0001-9106-0049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06663aac11174e88a79cbb8e2ec4f3c0.json"}}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Kirui", "given": "Brian", "initials": "B", "orcid": "0000-0002-6656-6029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b22b96547b344c79b3780723af1f30e0.json"}}, {"family": "Santosa", "given": "Ailiana", "initials": "A", "orcid": "0000-0002-1848-2867", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/049cb4da029a4e7491b6914f93e8bf17.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}, {"family": "Leach", "given": "Susannah", "initials": "S", "orcid": "0000-0002-9614-2753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18d00be831d241dca238b3253d1b45f6.json"}}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW", "orcid": "0000-0002-4387-4096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bb5d1f761ef48c4837ed4f984717f0e.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2022-12-05", "journal": {"title": "Vaccines", "issn": "2076-393X", "issn-l": null, "volume": "10", "issue": "12", "pages": null}, "abstract": "We estimated real-world vaccine effectiveness (VE) against COVID-19 infection, hospitalization, ICU admission, and death up to 13 months after vaccination. VE before and after the emergence of Omicron was investigated.\r\n\r\nWe used registered data from the entire Swedish population above age 12 (n = 9,153,456). Cox regression with time-varying exposure was used to estimate weekly/monthly VE against COVID-19 outcomes from 27 December 2020 to 31 January 2022. The analyses were stratified by age, sex, and vaccine type (BNT162b2, mRNA-1273, and AZD1222).\r\n\r\nTwo vaccine doses offered good long-lasting protection against infection before Omicron (VE were above 85% for all time intervals) but limited protection against Omicron infection (dropped to 43% by week four and no protection by week 14). For severe COVID-19 outcomes, higher VE was observed during the entire follow-up period. Among individuals above age 65, the mRNA vaccines showed better VE against infection than AZD1222 but similar high VE against hospitalization.\r\n\r\nOur findings provide strong evidence for long-term maintained protection against severe COVID-19 by the basic two-dose schedule, supporting more efforts to encourage unvaccinated persons to get the basic two doses, and encourage vaccinated persons to get a booster to ensure better population-level protection.", "doi": "10.3390/vaccines10122074", "pmid": "36560484", "labels": {"Category: Omicron VoC": null, "Category: Vaccines": null, "Category: Health": null, "Type: Journal article": null, "Research Area: Vaccine": null, "Funder: KAW/SciLifeLab": null, "Topics: Register-based research": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC9782222"}, {"db": "pii", "key": "vaccines10122074"}], "notes": [], "created": "2023-01-11T07:10:07.512Z", "modified": "2023-01-13T10:03:13.606Z"}, {"entity": "publication", "iuid": "e9d5aabd4b404ca2a149b7d83644bbc2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e9d5aabd4b404ca2a149b7d83644bbc2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e9d5aabd4b404ca2a149b7d83644bbc2"}}, "title": "Dying during the COVID-19 Pandemic in Sweden: Relatives' Experiences of End-of-Life Care (the CO-LIVE Study).", "authors": [{"family": "Hedman", "given": "Christel", "initials": "C", "orcid": "0000-0003-4183-7598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f207650ce40e46e5b3ab9d7b716684e7.json"}}, {"family": "F\u00fcrst", "given": "Carl Johan", "initials": "CJ"}, {"family": "Rasmussen", "given": "Birgit H", "initials": "BH", "orcid": "0000-0003-0830-6058", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb3b0176d4654420acbc791974c7cb36.json"}}, {"family": "van der Heide", "given": "Agnes", "initials": "A"}, {"family": "Schelin", "given": "Maria E C", "initials": "MEC"}], "type": "journal article", "published": "2022-12-02", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "23", "issn-l": null}, "abstract": "The COVID-19 pandemic has seen many deaths, but the majority were for causes other than COVID-19. However, end-of-life care in all settings has been affected by measures limiting the spread of the virus, for patients with and without COVID-19. The Swedish coronavirus strategy was different compared to many other countries, which might have affected end-of-life care. The aim was to describe the experiences of end-of-life care for bereaved relatives in Sweden during the \"first wave\" and to compare the experiences for deaths due to COVID-19 with the experiences for deaths for other reasons.\n\nA random sample of addresses for 2400 people who died during March-September 2020 was retrieved from the Swedish Person Address Registry. Relatives were contacted with a questionnaire regarding their experience of end-of-life care, with a focus on communication, participation, and trust.\n\nIn total, 587 relatives (25% response rate) answered the questionnaire (14% COVID-19-deaths, 65% non-COVID-19-deaths, 21% uncertain). In the COVID-19 group 28% of the relatives were allowed visits without restrictions compared to 60% in the non-COVID-19 group (p &lt; 0.01). Only 28% of the relatives in the COVID-19 group reported that the person received \"enough care from physicians\", significantly fewer than the non-COVID group (65%, p &lt; 0.01).\n\nRelatives' experience of end-of-life care for persons with COVID-19 was significantly worse than relatives of persons without COVID-19, but relatives for persons without COVID-19 were also negatively affected.", "doi": "10.3390/ijerph192316146", "pmid": "36498221", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9740982"}, {"db": "pii", "key": "ijerph192316146"}], "notes": [], "created": "2023-01-13T13:30:38.545Z", "modified": "2023-01-13T13:30:38.625Z"}, {"entity": "publication", "iuid": "01d0dfdb226e48828101c520ca11852b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01d0dfdb226e48828101c520ca11852b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01d0dfdb226e48828101c520ca11852b"}}, "title": "The significance of the COVID-19 pandemic for family caregivers of non-COVID-19 patients in need of specialized palliative care at home: a qualitative study.", "authors": [{"family": "Wind", "given": "Gitte", "initials": "G", "orcid": "0000-0002-4907-4225", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59fa80d82c57425cb5654bae8f943cbf.json"}}, {"family": "Vedsegaard", "given": "Helle Wendner", "initials": "HW", "orcid": "0000-0003-0642-0877", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc7be809bef544df89b4aaab46a2de36.json"}}, {"family": "Marsaa", "given": "Kristoffer", "initials": "K", "orcid": "0000-0001-7366-7533", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fb03be244644237ba3eb1a308b13e9d.json"}}, {"family": "True", "given": "Trine Solander", "initials": "TS", "orcid": "0000-0003-4778-3340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ea4a7e652b146fb8949ee69454cca77.json"}}, {"family": "Konradsen", "given": "Hanne", "initials": "H", "orcid": "0000-0002-7477-125X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b462d15cdeec4dcb8371e07cf2e97853.json"}}], "type": "journal article", "published": "2022-12-00", "journal": {"title": "Int J Qual Stud Health Well-being", "issn": "1748-2631", "volume": "17", "issue": "1", "pages": "2113021", "issn-l": null}, "abstract": "It is well known that being a family caregiver of a palliative patient in general is rewarding as well as burdensome. The COVID-19 pandemic may have exacerbated this situation. We therefore explored the significance of the COVID-19 pandemic for family caregivers of non-COVID-19 patients in need of specialized palliative care at home.\n\nOpen-ended, semi-structured telephone interviews were conducted with 15 family caregivers of patients treated by a specialized palliative outpatient unit in a Danish hospital. Interviews were analysed using inductive thematic analysis.\n\nFour themes concerning the significance of the COVID-19 pandemic were identified: 1) being a family caregiver of a patient whose lifespan is already limited, 2) dealing with the risk of passing on COVID-19 oneself, 3) dealing with the risk of others passing on COVID-19 to the patient at home, and 4) living with modified specialized palliative care.\n\nThe COVID-19 pandemic had a radical impact on some family caregivers causing emotional despair. They feared not only infecting the patient with SARS-CoV-2 to cause an untimely death but also being unable to be there for the patient during hospitalization, especially in the patient's final days.", "doi": "10.1080/17482631.2022.2113021", "pmid": "35979626", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9397423"}], "notes": [], "created": "2022-09-12T18:41:52.197Z", "modified": "2022-09-12T18:42:07.522Z"}, {"entity": "publication", "iuid": "192bd823143141d99c5ce6074b66c9cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/192bd823143141d99c5ce6074b66c9cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/192bd823143141d99c5ce6074b66c9cf"}}, "title": "Continuation of fibrate therapy in patients with metabolic syndrome and COVID-19: a beneficial regime worth pursuing.", "authors": [{"family": "Vuorio", "given": "Alpo", "initials": "A", "orcid": "0000-0002-5504-2959", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ced6a984e09a43b2805f1bc49faedaa1.json"}}, {"family": "Brinck", "given": "Jonas", "initials": "J"}, {"family": "Kovanen", "given": "Petri T", "initials": "PT", "orcid": "0000-0002-2532-367X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84f610f43369437ba754d852866a83dd.json"}}], "type": "journal article", "published": "2022-12-00", "journal": {"title": "Ann Med", "issn": "1365-2060", "volume": "54", "issue": "1", "pages": "1952-1955", "issn-l": null}, "abstract": "Based on separate protective mechanisms related to lipid metabolism, viral cell entry and inflammation, fibrate treatment might be advantageous among patients who have been taking fibrates before SARS-CoV-2 infection and continue taking them during the infection. Based on published data on hospitalized COVID-19 patients, we recommend that the clinicians should ask their patients with metabolic syndrome who are already taking fibrates to continue fibrate treatment during the COVID-19 illness. This recommendation applies to both outpatients and hospitalized patients. However, results from the ongoing randomized controlled trials (RCTs) using fenofibrate treatment for the prevention or treatment of COVID-19 have yet to prove that fenofibrate is clinically significant for this indication.KEY MESSAGESThe role of fibrates as a repurpose to treat SARS-CoV-2 is under investigation in at least three ongoing RCTs.Obesity, diabetes, hypertension and dyslipidaemia, individually or clustered as a discrete phenotype, the metabolic syndrome, typically associate with a more severe course of COVID-19.Fibrate treatment seems to be most advantageous among patients who have been taken fibrates before SARS-CoV-2 infection and are continuing to take them during the infection.We recommend that the clinicians encourage their patients who are already taking fibrate to continue using the drug throughout the COVID-19 illness.", "doi": "10.1080/07853890.2022.2095667", "pmid": "35818956", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9278418"}], "notes": [], "created": "2022-08-17T10:37:58.554Z", "modified": "2022-08-17T10:37:58.676Z"}, {"entity": "publication", "iuid": "960c8cf80a514f20bcaaede734be70f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/960c8cf80a514f20bcaaede734be70f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/960c8cf80a514f20bcaaede734be70f4"}}, "title": "Considering medical students' perception, concerns and needs for e-exam during COVID-19: a promising approach to improve subject specific e-exams.", "authors": [{"family": "Ziehfreund", "given": "Stefanie", "initials": "S", "orcid": "0000-0003-3176-1120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce3b717d48094ef79f02636755ea893a.json"}}, {"family": "Reifenrath", "given": "Johannes", "initials": "J"}, {"family": "Wijnen-Meijer", "given": "Marjo", "initials": "M"}, {"family": "Welzel", "given": "Julia", "initials": "J"}, {"family": "Sauter", "given": "Fabian", "initials": "F"}, {"family": "Wecker", "given": "Hannah", "initials": "H"}, {"family": "Biedermann", "given": "Tilo", "initials": "T"}, {"family": "Zink", "given": "Alexander", "initials": "A"}], "type": "journal article", "published": "2022-12-00", "journal": {"title": "Med Educ Online", "issn": "1087-2981", "volume": "27", "issue": "1", "pages": "2114131", "issn-l": null}, "abstract": "The COVID-19 pandemic forced a rapid shift to digital strategies including e-exams in medical schools. However, there are significant concerns, predominately from student perspectives, and further data is required to successfully establish e-assessment in the medical curricula. The objective of the study was to examine medical students' perceptions, concerns, and needs regarding e-assessment to establish a comprehensive e-exam based on these and previous findings and to evaluate its effectiveness in terms of examinee perceptions and further needs. During the 2021 summer term, a cross-sectional study using qualitative and quantitative methods was conducted among all 1077 students at the School of Medicine, Technical University of Munich. They were asked to provide information regarding their characteristics, preferred exam format, e-assessment perception, concerns, and needs in an online questionnaire. Based on these findings, a pilot e-exam including an e-exam preparation for the students were established and subsequently evaluated among 125 pilot e-exam examinees under study consideration via an online-questionnaire. Of the 317 pre-exam participants (73.2% female), 70.3% preferred in-person exams and showed concerns about the technological framework, privacy, and examination requirements. Qualitative analysis showed that these concerns lead to additional exam stress and fear of failure. The 34 (79.4% female) participants who participated in the evaluation survey showed a significantly more positive e-exam perception. The fairness of the platform, the independence from an internet connection, the organization including the e-exam preparation, and the consideration of participant needs were discussed as particularly positive in the open-ended comments. In both surveys, participants requested uniform platforms and processes for all subjects. This study provides evidence for a positive, complementary role of student participation in a successful e-exam implementation. Furthermore, when establishing an e-exam format in the medical curricula, e-exam training, equal accessibility, availability offline, and all-round fairness should be considered.", "doi": "10.1080/10872981.2022.2114131", "pmid": "35993348", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9397442"}], "notes": [], "created": "2022-09-12T18:53:10.704Z", "modified": "2022-09-12T18:53:10.829Z"}, {"entity": "publication", "iuid": "b558292026a7442ba7979879012b5a38", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b558292026a7442ba7979879012b5a38.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b558292026a7442ba7979879012b5a38"}}, "title": "Bayesian nowcasting with leading indicators applied to COVID-19 fatalities in Sweden.", "authors": [{"family": "Bergstr\u00f6m", "given": "Fanny", "initials": "F", "orcid": "0000-0002-0693-3851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fb53e3138c64a00ae6f60214d4d23b6.json"}}, {"family": "G\u00fcnther", "given": "Felix", "initials": "F"}, {"family": "H\u00f6hle", "given": "Michael", "initials": "M", "orcid": "0000-0002-0423-6702", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4c004a5b6de46d7baabeffdef938778.json"}}, {"family": "Britton", "given": "Tom", "initials": "T"}], "type": "journal article", "published": "2022-12-00", "journal": {"title": "PLoS Comput Biol", "issn": "1553-7358", "volume": "18", "issue": "12", "pages": "e1010767", "issn-l": null}, "abstract": "The real-time analysis of infectious disease surveillance data is essential in obtaining situational awareness about the current dynamics of a major public health event such as the COVID-19 pandemic. This analysis of e.g., time-series of reported cases or fatalities is complicated by reporting delays that lead to under-reporting of the complete number of events for the most recent time points. This can lead to misconceptions by the interpreter, for instance the media or the public, as was the case with the time-series of reported fatalities during the COVID-19 pandemic in Sweden. Nowcasting methods provide real-time estimates of the complete number of events using the incomplete time-series of currently reported events and information about the reporting delays from the past. In this paper we propose a novel Bayesian nowcasting approach applied to COVID-19-related fatalities in Sweden. We incorporate additional information in the form of time-series of number of reported cases and ICU admissions as leading signals. We demonstrate with a retrospective evaluation that the inclusion of ICU admissions as a leading signal improved the nowcasting performance of case fatalities for COVID-19 in Sweden compared to existing methods.", "doi": "10.1371/journal.pcbi.1010767", "pmid": "36477048", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC9762573"}, {"db": "pii", "key": "PCOMPBIOL-D-22-01107"}], "notes": [], "created": "2023-01-13T13:33:58.495Z", "modified": "2023-01-13T13:33:58.562Z"}, {"entity": "publication", "iuid": "08ccf53710c34f02a790a5405cea03b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/08ccf53710c34f02a790a5405cea03b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/08ccf53710c34f02a790a5405cea03b9"}}, "title": "Mental health outcomes following COVID-19 infection: impacts of post-COVID impairments and fatigue on depression, anxiety, and insomnia - a web survey in Sweden.", "authors": [{"family": "Badinlou", "given": "Farzaneh", "initials": "F"}, {"family": "Lundgren", "given": "Tobias", "initials": "T"}, {"family": "Jansson-Fr\u00f6jmark", "given": "Markus", "initials": "M"}], "type": "journal article", "published": "2022-11-29", "journal": {"title": "BMC Psychiatry", "issn": "1471-244X", "volume": "22", "issue": "1", "pages": "743", "issn-l": null}, "abstract": "The negative impact of the COVID-19 pandemic on the mental health is now clearly established. However, information on the levels of mental ill health of people infected with COVID-19 and potential correlates of poor mental health is still limited. Therefore, the current study aimed to study indicative of potential mental health problems in individuals with a history of probable or confirmed SARS CoV-2 infection/infections and address the impacts of post-COVID impairments and fatigue following COVID-19 infection/infections on depression, anxiety, and insomnia.\n\nA web-survey including demographics, questions related to COVID-19 status and post-COVID impairments, and standardized measures of depression, anxiety, insomnia, and fatigue was completed by 507 individuals with a history of probable or confirmed SARS CoV-2 infection/infections.\n\nWe found significant rates of significant depression, anxiety, and insomnia in our sample, with more than 70% experiencing levels above the clinical cut offs for at least one psychological health problems. Higher levels of depression, anxiety, and insomnia were associated with the severity of COVID-19 infection in the acute phase, hospitalization because of COVID-19, and higher levels of post-COVID impairments and fatigue. Reduced motivation emerged as the strongest predictor for mental ill health.\n\nThese findings highlight that individuals infected with COVID-19, especially those who still have experienced post-COVID impairments, are more likely to suffer from mental ill-health and may be more vulnerable for poor mental health outcomes. Therefore, more effective actions are needed to take in order to promote and protect mental health of individuals with a history of COVID-19 infection.", "doi": "10.1186/s12888-022-04405-0", "pmid": "36447183", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9708120"}, {"db": "pii", "key": "10.1186/s12888-022-04405-0"}], "notes": [], "created": "2023-01-13T13:49:40.950Z", "modified": "2023-01-13T13:49:40.952Z"}, {"entity": "publication", "iuid": "f2224afaa64745eca88acf3366c2efdb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f2224afaa64745eca88acf3366c2efdb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f2224afaa64745eca88acf3366c2efdb"}}, "title": "Media use and trust during the COVID-19 pandemic: evidence from eight cross-sectional surveys in Sweden.", "authors": [{"family": "Winters", "given": "Maike", "initials": "M", "orcid": "0000-0003-0915-6506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35b530d67b244b999f697b2923b32bbf.json"}}, {"family": "Biermann", "given": "Olivia", "initials": "O"}, {"family": "Bohlin", "given": "Gustav", "initials": "G"}, {"family": "Bergman", "given": "Martin", "initials": "M"}, {"family": "Broun\u00e9us", "given": "Fredrik", "initials": "F"}, {"family": "Zeebari", "given": "Zangin", "initials": "Z"}, {"family": "Nordenstedt", "given": "Helena", "initials": "H"}], "type": "journal article", "published": "2022-11-29", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "volume": "32", "issue": "6", "pages": "976-981", "issn-l": "1101-1262"}, "abstract": "While a lot has been written about Sweden's COVID-19 control strategy, less is known about Swedish residents' media use during the pandemic and trust in and perceived agreement among key stakeholders commenting in the media.\n\nEight online, nationwide surveys were fielded between March and August 2020, during the first wave of the coronavirus pandemic in Sweden, with 8146 responses. Questions were asked on media usage, perceived tone of media, trust in key pandemic stakeholder groups commenting in the media (politicians, journalists, government officials, doctors/healthcare professionals and researchers) and perceived agreement among these key stakeholders about how the pandemic was handled in Sweden.\n\nUsing five or more information sources was associated with increased perceived alarmism in the media. Women and those with tertiary education were more likely to trust key pandemic actors. Trust in doctors/healthcare professionals and researchers remained high over the course of the study, trust in politicians and journalists was relatively low throughout the study period, with a slight increase in April 2020. Trust in key stakeholders was strongly associated with perceived agreement among the key stakeholders.\n\nOur results show that trust in stakeholders was strongly associated with perceived consistency of messages from those stakeholders. The inverse also holds: perceived conflicting messages among stakeholders was associated with low trust in them. Taken together, this could point to the importance of building trust before a crisis. Trust-building efforts could be targeted to men and those with lower educational attainment, as they had lower trust in key stakeholders.", "doi": "10.1093/eurpub/ckac145", "pmid": "36223605", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC9619753"}, {"db": "pii", "key": "6759691"}], "notes": [], "created": "2023-01-13T13:55:42.245Z", "modified": "2023-01-13T13:55:42.281Z"}, {"entity": "publication", "iuid": "bae809b1d1e2474b8e24f68b4c332315", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bae809b1d1e2474b8e24f68b4c332315.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bae809b1d1e2474b8e24f68b4c332315"}}, "title": "Mucosal IgA against SARS-CoV-2 Omicron Infection. Reply.", "authors": [{"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "letter", "published": "2022-11-24", "journal": {"title": "N Engl J Med", "issn": "1533-4406", "issn-l": null, "volume": "387", "issue": "21", "pages": "e55"}, "abstract": null, "doi": "10.1056/NEJMc2213153", "pmid": "36416779", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: H2020": null, "Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "10.1056/NEJMc2213153#sa2"}], "notes": [], "created": "2022-11-25T07:15:01.636Z", "modified": "2022-11-25T07:17:36.842Z"}, {"entity": "publication", "iuid": "70c6b11ead9f439c85df5c95971b36e6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70c6b11ead9f439c85df5c95971b36e6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70c6b11ead9f439c85df5c95971b36e6"}}, "title": "Effects of COVID-19 on the Human Central Olfactory System: A Natural Pre-Post Experiment", "authors": [{"family": "Thunell", "given": "E", "initials": "E", "orcid": "0000-0002-9368-4661", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5da807e735af4a5a8a933fae9b7facc4.json"}}, {"family": "Peter", "given": "M G", "initials": "MG", "orcid": "0000-0003-4472-795X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb77dd5d98864db79f47b9c59edb3530.json"}}, {"family": "Lenoir", "given": "V", "initials": "V", "orcid": "0000-0002-8140-8010", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a2fcaf4f76849ffb23f71e1289381df.json"}}, {"family": "Andersson", "given": "P", "initials": "P", "orcid": "0000-0001-9807-446X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87b95f3d1c8a4aecaa0a7ebfa9e6d0a6.json"}}, {"family": "Landis", "given": "B N", "initials": "BN", "orcid": "0000-0001-6034-3724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14b3e598649c40998778371286527b8c.json"}}, {"family": "Becker", "given": "M", "initials": "M", "orcid": "0000-0001-9644-9053", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00c51cc049aa40799398a72230f16c0d.json"}}, {"family": "Lundstr\u00f6m", "given": "J N", "initials": "JN", "orcid": "0000-0002-3529-8981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a92f50aea024a1fbf0cfda979efef11.json"}}], "type": "journal-article", "published": "2022-11-24", "journal": {"title": "AJNR Am J Neuroradiol", "issn": "0195-6108", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.3174/ajnr.a7713", "pmid": "36423956", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:42:39.664Z", "modified": "2022-11-25T07:11:04.729Z"}, {"entity": "publication", "iuid": "7ab0920969114ec5909c80f2bd372253", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7ab0920969114ec5909c80f2bd372253.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7ab0920969114ec5909c80f2bd372253"}}, "title": "Corrigendum: Vaccine safety surveillance using routinely collected healthcare data-An empirical evaluation of epidemiological designs.", "authors": [{"family": "Schuemie", "given": "Martijn J", "initials": "MJ"}, {"family": "Arshad", "given": "Faaizah", "initials": "F"}, {"family": "Pratt", "given": "Nicole", "initials": "N"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Lai", "given": "Lana Y H", "initials": "LYH"}, {"family": "Li", "given": "Xintong", "initials": "X"}, {"family": "Fortin", "given": "Stephen", "initials": "S"}, {"family": "Minty", "given": "Evan", "initials": "E"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}], "type": "published erratum", "published": "2022-11-24", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "13", "pages": "1088973", "issn-l": "1663-9812"}, "abstract": "[This corrects the article DOI: 10.3389/fphar.2022.893484.].", "doi": "10.3389/fphar.2022.1088973", "pmid": "36506524", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9731373"}, {"db": "pii", "key": "1088973"}], "notes": [], "created": "2023-01-13T10:01:41.744Z", "modified": "2023-01-13T10:01:41.747Z"}, {"entity": "publication", "iuid": "0e008e3a54a5489dbbdbe804147970ba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e008e3a54a5489dbbdbe804147970ba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e008e3a54a5489dbbdbe804147970ba"}}, "title": "Why women choose self-managed telemedicine abortion in the Netherlands during the COVID-19 pandemic: a national mixed methods study.", "authors": [{"family": "Cui", "given": "Nanke", "initials": "N", "orcid": "0000-0001-6780-7106", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b76f8edda00f4355bb31d820f7183366.json"}}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}, {"family": "Gomperts", "given": "Rebecca", "initials": "R"}], "type": "journal article", "published": "2022-11-21", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-2009", "issn-l": "2515-1991"}, "abstract": "The COVID-19 pandemic has imposed strict lockdown restrictions that have introduced barriers to in-person abortion clinic visits in the Netherlands. Women on Web (WoW) is a global medical abortion telemedicine service operating outside the formal health sector.\n\nTo understand the motivations and perceived barriers women faced when choosing telemedicine abortion outside the formal health sector, and how this was affected by the pandemic.\n\n178 women who completed an online consultation on the Dutch WoW website during the period 6 March 2020 to 5 March 2021 were included in this cross-sectional cohort study and exploratory qualitative study. Patient characteristics and motivations were analysed and associated with the severity of COVID-19 restrictions. Email exchanges in which women could further describe their requests were also examined for recurrent clarification of motivations.\n\nWomen experienced barriers to regular abortion care due to COVID-19 restrictions and had the preference to (1) self-manage their abortion, (2) stay in the comfort of their own home, and (3) keep their abortion private. In particular, women who did not live in the cities where abortion clinics were located experienced barriers to abortion services. As COVID-19 restrictions tightened, it was more frequently mentioned that women sought help from WoW because COVID-19 restrictions and abortion care were not accessible to them in the Netherlands. In the qualitative analysis of email exchanges, the reasons of COVID-19, privacy concerns, and domestic violence were particularly evident.\n\nIn the Netherlands, barriers to receiving adequate abortion care were exacerbated for women in vulnerable positions such as being geographically farther away from an abortion clinic, being in a deprived socioeconomic position, or being in an unsafe home situation. Similar to other medical care, abortion care should be deliverable online.", "doi": "10.1136/bmjsrh-2022-201591", "pmid": "36410763", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjsrh-2022-201591"}], "notes": [], "created": "2022-11-22T10:00:11.822Z", "modified": "2022-11-22T10:00:28.944Z"}, {"entity": "publication", "iuid": "7b8c22670a484cbdac5ca3ae2436fe17", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b8c22670a484cbdac5ca3ae2436fe17.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b8c22670a484cbdac5ca3ae2436fe17"}}, "title": "Human cytomegalovirus infection of epithelial cells increases SARS-CoV-2 superinfection by upregulating the ACE2 receptor.", "authors": [{"family": "Perera", "given": "Marianne R", "initials": "MR", "orcid": "0000-0001-9175-0568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/455783d64b804bb18b75d77628a63d82.json"}}, {"family": "Greenwood", "given": "Edward Jd", "initials": "EJ"}, {"family": "Crozier", "given": "Thomas Wm", "initials": "TW"}, {"family": "Elder", "given": "Elizabeth G", "initials": "EG"}, {"family": "Schmitt", "given": "Janika", "initials": "J"}, {"family": "Crump", "given": "Colin M", "initials": "CM"}, {"family": "Lehner", "given": "Paul J", "initials": "PJ"}, {"family": "Wills", "given": "Mark R", "initials": "MR"}, {"family": "Sinclair", "given": "John H", "initials": "JH"}], "type": "journal article", "published": "2022-11-21", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899"}, "abstract": "SARS-CoV-2, the causative agent of COVID-19, has caused widespread morbidity and mortality since its onset in late 2019. Here, we demonstrate that prior infection with human cytomegalovirus (HCMV) substantially increases infection with SARS-CoV-2 in vitro. HCMV is a common herpesvirus carried by 40-100% of the population which can reactivate in the lung under inflammatory conditions, such as those resulting from SARS-CoV-2 infection. We show in both endothelial and epithelial cell types that HCMV infection upregulates ACE2, the SARS-CoV-2 cell entry receptor. These observations suggest that HCMV reactivation events in the lung of healthy HCMV carriers could exacerbate SARS-CoV-2 infection and subsequent COVID-19 symptoms. This effect could contribute to the disparity of disease severity seen in ethnic minorities and those with lower socio-economic status, due to their higher CMV seroprevalence. Our results warrant further clinical investigation as to whether HCMV infection influences the pathogenesis of SARS-CoV-2.", "doi": "10.1093/infdis/jiac452", "pmid": "36408607", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6835053"}], "notes": [], "created": "2022-11-22T10:02:17.593Z", "modified": "2022-11-22T10:02:17.628Z"}, {"entity": "publication", "iuid": "84ce80a5ceb44e6ea8458c999fea427b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84ce80a5ceb44e6ea8458c999fea427b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84ce80a5ceb44e6ea8458c999fea427b"}}, "title": "Detection of SARS-CoV-2 antibodies in serum and dried blood spot samples of vaccinated individuals using a sensitive homogeneous proximity extension assay.", "authors": [{"family": "Zhao", "given": "Hongxing", "initials": "H"}, {"family": "Wang", "given": "Mengqi", "initials": "M"}, {"family": "Muthelo", "given": "Phathutshedzo", "initials": "P"}, {"family": "L\u00f6f", "given": "Liza", "initials": "L"}, {"family": "Sterky", "given": "Fredrik", "initials": "F"}, {"family": "Gallini", "given": "Radiosa", "initials": "R"}, {"family": "Kumar", "given": "Nallani Vijay", "initials": "NV"}, {"family": "Monsen", "given": "Tor", "initials": "T"}, {"family": "Nilsson", "given": "Kenneth", "initials": "K"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Kamali-Moghaddam", "given": "Masood", "initials": "M"}, {"family": "Mei", "given": "Ya-Fang", "initials": "YF"}, {"family": "Landegren", "given": "Ulf", "initials": "U"}], "type": "journal article", "published": "2022-11-21", "journal": {"title": "N Biotechnol", "issn": "1876-4347", "issn-l": null}, "abstract": "A homogeneous PCR-based assay for sensitive and specific detection of antibodies in serum or dried blood spots (DBS) is presented and the method is used to monitor individuals infected with or vaccinated against SARS-CoV-2. Detection probes were prepared by conjugating the recombinant spike protein subunit 1 (S1), containing the receptor binding domain (RBD) of SARS-CoV-2, to each of a pair of specific oligonucleotides. The same was done for the nucleocapsid protein (NP). Upon incubation with serum or DBS samples, the bi- or multivalency of the antibodies (IgG, IgA or IgM) brings pairs of viral proteins with their conjugated oligonucleotides in proximity and can be detected by a modified proximity extension assay (PEA). Anti-S1 and anti-NP antibodies could be detected simultaneously from one incubation reaction. This Antibody PEA (AbPEA) test uses only 1\u00b5l of neat or up to 100,000-fold diluted serum or one \u00f81.2mm disc cut from a DBS. All 100 investigated sera and 21 DBS collected prior to the COVID-19 outbreak were negative, demonstrating a 100% specificity. The area under the curve, as evaluated by the Receiver Operating Characteristic (ROC) analysis reached 0.998 (95%CI: 0.993-1) for samples taken from 11 days after symptoms onset. The kinetics of antibody responses were monitored after a first and second vaccination using serially collected DBS from 14 individuals. AbPEA offers highly specific and sensitive solution-phase antibody detection without requirement for secondary antibodies, no elution step when using DBS sample and a simple procedure that lends itself to multiplex survey of antibody responses.", "doi": "10.1016/j.nbt.2022.11.004", "pmid": "36423830", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1871-6784(22)00063-2"}], "notes": [], "created": "2022-11-25T07:12:23.583Z", "modified": "2022-11-25T07:12:47.576Z"}, {"entity": "publication", "iuid": "d576447f4dd14b6dae0e0cb5e7ea381e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d576447f4dd14b6dae0e0cb5e7ea381e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d576447f4dd14b6dae0e0cb5e7ea381e"}}, "title": "A comprehensive characterisation of patients diagnosed with post-COVID-19 condition in Sweden 16 months after the introduction of the ICD-10 diagnosis code (U09.9): a population-based cohort study.", "authors": [{"family": "Bygdell", "given": "Maria", "initials": "M"}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Lundberg", "given": "Lisa", "initials": "L"}, {"family": "Gyll", "given": "David", "initials": "D"}, {"family": "Martikainen", "given": "Jari", "initials": "J"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2022-11-18", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": null, "issue": null, "pages": null}, "abstract": "The objective of this study was to provide a comprehensive characterisation of patients diagnosed with post-COVID-19 condition (PCC) during the first 16 months of usage of the International Classification of Diseases revision 10 (ICD-10) diagnosis code U09.9 in Sweden.\n\nWe used data from national registers and primary healthcare databases for all adult inhabitants of the two largest regions in Sweden, comprising 4.1 million inhabitants (approximately 40% of the Swedish population). We present the cumulative incidence and incidence rate of PCC overall and among subgroups and describe COVID-19 patients with or without PCC regarding sociodemographic characteristics, comorbidities, subsequent diseases, COVID-19 severity, and virus variants.\n\nOf all registered COVID-19 cases available for PCC diagnosis (n=506,107), 2.0% (n=10,196) had been diagnosed with PCC using ICD-10 code U09.9 as of 15 February 2022 in the two largest regions in Sweden. The cumulative incidence was higher among women compared to men (2.3% vs 1.6%, p<0.001). The majority of PCC cases (n=7,162, 70.2%) had not been hospitalised for COVID-19. This group was more commonly female (69.9% vs 52.9%, p<0.001), had a tertiary education (51.0% vs 44.1%, p<0.001), and was older (median age difference 5.7 years, p<0.001) compared to non-hospitalised COVID-19 patients without PCC.\n\nThis characterisation furthers the understanding of patients diagnosed with PCC and could support policymakers with appropriate societal and healthcare resource allocation.", "doi": "10.1016/j.ijid.2022.11.021", "pmid": "36410693", "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Research Area: Call 1": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(22)00612-9"}], "notes": [], "created": "2022-11-22T10:01:50.032Z", "modified": "2022-11-25T07:21:32.562Z"}, {"entity": "publication", "iuid": "302309021a0f49308e65147d54053a8e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/302309021a0f49308e65147d54053a8e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/302309021a0f49308e65147d54053a8e"}}, "title": "Self-reported symptom severity, general health, and impairment in post-acute phases of COVID-19: retrospective cohort study of Swedish public employees.", "authors": [{"family": "Larsson", "given": "Simon B", "initials": "SB"}, {"family": "von Feilitzen", "given": "Gustaf Stuk\u00e1t", "initials": "GS"}, {"family": "Andersson", "given": "Maria E", "initials": "ME"}, {"family": "Sikora", "given": "Per", "initials": "P"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Nord\u00e9n", "given": "Rickard", "initials": "R"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Sigstr\u00f6m", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2022-11-17", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "19818", "issn-l": "2045-2322"}, "abstract": "This study aimed to examine current symptom severity and general health in a sample of primarily non-hospitalized persons with polymerase chain reaction (PCR) confirmed COVID-19 in comparison to PCR negative controls. During the first quarter of 2021, we conducted an online survey among public employees in West Sweden, with a valid COVID-19 test result. The survey assessed past-month severity of 28 symptoms and signs, self-rated health, the WHO Disability Assessment Schedule (WHODAS) 2.0 and illness severity at the time of test. We linked participants' responses to their SARS-CoV-2 PCR tests results. We compared COVID-19 positive and negative participants using univariable and multivariable regression analyses. Out of 56,221 invited, 14,222 (25.3%) responded, with a response rate of 50% among SARS-CoV-2 positive individuals. Analysis included 10,194 participants (86.4% women, mean age 45 years) who tested positive 4-12 weeks (N = 1425; subacute) and > 12 weeks (N = 1584; postcovid) prior to the survey, and 7185 PCR negative participants who did not believe that they had had COVID-19. Symptoms were highly prevalent in all groups, with worst symptoms in subacute phase participants, followed by postcovid phase and PCR negative participants. The most specific symptom for COVID-19 was loss of smell or taste. Both WHODAS 2.0 score and self-rated health were worst in subacute participants, and modestly worse in postcovid participants than in negative controls. Female gender, older age and acute illness severity had larger effects on self-rated health and WHODAS 2.0 score in PCR positive participants than in PCR negative. Studies with longer follow-up are needed to determine the long-term improvement after COVID-19.", "doi": "10.1038/s41598-022-24307-1", "pmid": "36396860", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9672032"}, {"db": "pii", "key": "10.1038/s41598-022-24307-1"}], "notes": [], "created": "2022-11-25T07:23:08.875Z", "modified": "2022-11-25T07:23:08.878Z"}, {"entity": "publication", "iuid": "bb8633cac6b742179bc3ea753f065938", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb8633cac6b742179bc3ea753f065938.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb8633cac6b742179bc3ea753f065938"}}, "title": "A population-based, retrospective cohort study of the association between ABO blood group and risk of COVID-19.", "authors": [{"family": "Dahl\u00e9n", "given": "Torsten", "initials": "T", "orcid": "0000-0002-3856-7227", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69a3a4703c134438836a76bd0dec1c68.json"}}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Edgren", "given": "Gustaf", "initials": "G", "orcid": "0000-0002-2198-4745", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8202fb97787474d931b94103878cf32.json"}}], "type": "journal article", "published": "2022-11-13", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null}, "abstract": "Several studies have investigated associations between ABO blood group and risk of COVID-19, with inconsistent results.\n\nTo study associations between ABO blood group and risk of different stages of COVID-19.\n\nThe study was based on nationwide registers encompassing all blood-grouped persons in Sweden, and all of their COVID-19 related outcomes. Associations between ABO blood group and COVID-19 outcomes were estimated using Poisson regression models. Analyses were conducted overall and stratified by vaccination status.\n\nA total of 4,986,878 individuals were included. The incidence rate ratios (IRRs), of testing positive for COVID-19 were 1.08 (95% confidence interval [CI], 1.07-1.08), 1.06 (95% CI, 1.05-1.07), and 1.01 (95% CI, 1.00-1.01) for blood groups A, AB, and B, as compared to O, respectively. Similar associations were seen for risk of hospital admissions, ICU admissions, and risk of death. For most outcomes, associations with ABO blood group were much attenuated or even reversed in vaccinated individuals.\n\nIndividuals with blood groups A, AB, and B are at increased risk of contracting COVID-19 as well as developing more severe forms of the disease. This article is protected by copyright. All rights reserved.", "doi": "10.1111/joim.13588", "pmid": "36372955", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-11-25T10:44:16.941Z", "modified": "2022-11-25T10:44:17.014Z"}, {"entity": "publication", "iuid": "48d95388505149eaa1f7304347c87a05", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/48d95388505149eaa1f7304347c87a05.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/48d95388505149eaa1f7304347c87a05"}}, "title": "Long-term SARS-CoV-2 surveillance in the wastewater of Stockholm: What lessons can be learned from the Swedish perspective?", "authors": [{"family": "Perez-Zabaleta", "given": "Mariel", "initials": "M"}, {"family": "Archer", "given": "Amena", "initials": "A"}, {"family": "Khatami", "given": "Kasra", "initials": "K"}, {"family": "Jafferali", "given": "Mohammed Hakim", "initials": "MH"}, {"family": "Nandy", "given": "Prachi", "initials": "P"}, {"family": "Atasoy", "given": "Merve", "initials": "M"}, {"family": "Birgersson", "given": "Madeleine", "initials": "M"}, {"family": "Williams", "given": "Cecilia", "initials": "C"}, {"family": "Cetecioglu", "given": "Zeynep", "initials": "Z"}], "type": "journal article", "published": "2022-11-08", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "volume": "858", "issue": "Pt 3", "pages": "160023", "issn-l": "0048-9697"}, "abstract": "Wastewater-based epidemiology (WBE) can be used to track the spread of SARS-CoV-2 in a population. This study presents the learning outcomes from over two-year long monitoring of SARS-CoV-2 in Stockholm, Sweden. The three main wastewater treatment plants in Stockholm, with a total of six inlets, were monitored from April 2020 until June 2022 (in total 600 samples). This spans five major SARS-CoV-2 waves, where WBE data provided early warning signals for each wave. Further, the measured SARS-CoV-2 content in the wastewater correlated significantly with the level of positive COVID-19 tests (r = 0.86; p << 0.0001) measured by widespread testing of the population. Moreover, as a proof-of-concept, six SARS-CoV-2 variants of concern were monitored using hpPCR assay, demonstrating that variants can be traced through wastewater monitoring. During this long-term surveillance, two sampling protocols, two RNA concentration/extraction methods, two calculation approaches, and normalization to the RNA virus Pepper mild mottle virus (PMMoV) were evaluated. In addition, a study of storage conditions was performed, demonstrating that the decay of viral RNA was significantly reduced upon the addition of glycerol to the wastewater before storage at -80 \u00b0C. Our results provide valuable information that can facilitate the incorporation of WBE as a prediction tool for possible future outbreaks of SARS-CoV-2 and preparations for future pandemics.", "doi": "10.1016/j.scitotenv.2022.160023", "pmid": "36356735", "labels": {"Category: Other": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Research Area: Environmental virus profiling": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9640212"}, {"db": "pii", "key": "S0048-9697(22)07123-6"}], "notes": [], "created": "2022-11-25T10:50:01.947Z", "modified": "2022-11-25T10:50:01.951Z"}, {"entity": "publication", "iuid": "acbce148a528462aab930c001ed75746", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/acbce148a528462aab930c001ed75746.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/acbce148a528462aab930c001ed75746"}}, "title": "Innate immune mechanisms of mRNA vaccines.", "authors": [{"family": "Verbeke", "given": "Rein", "initials": "R"}, {"family": "Hogan", "given": "Michael J", "initials": "MJ"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "Pardi", "given": "Norbert", "initials": "N"}], "type": "journal article", "published": "2022-11-08", "journal": {"title": "Immunity", "issn": "1074-7613", "volume": "55", "issue": "11", "pages": "1993-2005", "issn-l": null}, "abstract": "The lipid nanoparticle (LNP)-encapsulated, nucleoside-modified mRNA platform has been used to generate safe and effective vaccines in record time against COVID-19. Here, we review the current understanding of the manner whereby mRNA vaccines induce innate immune activation and how this contributes to protective immunity. We discuss innate immune sensing of mRNA vaccines at the cellular and intracellular levels and consider the contribution of both the mRNA and the LNP components to their immunogenicity. A key message that is emerging from recent observations is that the LNP carrier acts as a powerful adjuvant for this novel vaccine platform. In this context, we highlight important gaps in understanding and discuss how new insight into the mechanisms underlying the effectiveness of mRNA-LNP vaccines may enable tailoring mRNA and carrier molecules to develop vaccines with greater effectiveness and milder adverse events in the future.", "doi": "10.1016/j.immuni.2022.10.014", "pmid": "36351374", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC9641982"}, {"db": "pii", "key": "S1074-7613(22)00555-6"}], "notes": [], "created": "2022-11-25T10:51:09.699Z", "modified": "2022-11-25T10:51:09.708Z"}, {"entity": "publication", "iuid": "4bf9511a136b46edaede7c1cedfd44a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4bf9511a136b46edaede7c1cedfd44a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4bf9511a136b46edaede7c1cedfd44a4"}}, "title": "Size distribution of exhaled aerosol particles containing SARS-CoV-2 RNA.", "authors": [{"family": "Alsved", "given": "Malin", "initials": "M", "orcid": "0000-0002-8407-8758", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f599d60401c1483a9422fbb048c6d050.json"}}, {"family": "Nygren", "given": "David", "initials": "D", "orcid": "0000-0003-2426-7204", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d84ae6e240ec4a3caaf519a43f9d7cf9.json"}}, {"family": "Thuresson", "given": "Sara", "initials": "S", "orcid": "0000-0001-8243-3632", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21b29967898c42dd87cd587d662500d5.json"}}, {"family": "Fraenkel", "given": "Carl-Johan", "initials": "CJ", "orcid": "0000-0002-3086-5553", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6aec05367593436baef9decc3616e9c9.json"}}, {"family": "Medstrand", "given": "Patrik", "initials": "P", "orcid": "0000-0003-4259-8744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/558185ff31d94cacb1931015f2e12be4.json"}}, {"family": "L\u00f6ndahl", "given": "Jakob", "initials": "J", "orcid": "0000-0001-9379-592X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7648041474a8469aa54218ca177e4c19.json"}}], "type": "journal article", "published": "2022-11-04", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "pages": "1-6", "issn-l": "2374-4235"}, "abstract": "SARS-CoV-2 in exhaled aerosols is considered an important contributor to the spread of COVID-19. However, characterizing the size distribution of virus-containing aerosol particles has been challenging as high concentrations of SARS-CoV-2 in exhaled air is mainly present close to symptom onset. We present a case study of a person with COVID-19 who was able to participate in extensive measurements of exhaled aerosols already on the day of symptom onset and then for the following three days.\n\nAerosol collection was performed using an eight-stage impactor while the subject was breathing, talking and singing, for 30 min each, once every day. In addition, nasopharyngeal samples, saliva samples, room air samples and information on symptom manifestations were collected every day. Samples were analyzed by RT-qPCR for detection of SARS-CoV-2 RNA.\n\nSARS-CoV-2 RNA was detected in seven of the eight particle size fractions, from 0.34 to >8.1 \u00b5m, with the highest concentrations found in 0.94-2.8 \u00b5m particles. The concentration of SARS-CoV-2 RNA was highest on the day of symptom onset, and declined for each day thereafter.\n\nOur data showed that 90% of the exhaled SARS-CoV-2 RNA was found in aerosol particles <4.5 \u00b5m, indicating the importance of small particles for the transmission of COVID-19 close to symptom onset. These results are important for our understanding of airborne transmission, for developing accurate models and for selecting appropriate mitigation strategies.", "doi": "10.1080/23744235.2022.2140822", "pmid": "36331347", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Funder: Forte": null, "Type: Journal article": null, "Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-11-25T10:53:30.989Z", "modified": "2022-11-25T10:53:45.902Z"}, {"entity": "publication", "iuid": "9b06a05223c148d0b2e540a049dd360d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b06a05223c148d0b2e540a049dd360d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b06a05223c148d0b2e540a049dd360d"}}, "title": "An intersectional analysis of sociodemographic disparities in Covid-19 vaccination: A nationwide register-based study in Sweden.", "authors": [{"family": "Spetz", "given": "M", "initials": "M"}, {"family": "Lundberg", "given": "L", "initials": "L"}, {"family": "Nwaru", "given": "C", "initials": "C"}, {"family": "Li", "given": "H", "initials": "H"}, {"family": "Santosa", "given": "A", "initials": "A"}, {"family": "Ng", "given": "N", "initials": "N"}, {"family": "Leach", "given": "S", "initials": "S"}, {"family": "Gissl\u00e9n", "given": "M", "initials": "M"}, {"family": "Hammar", "given": "N", "initials": "N"}, {"family": "Nyberg", "given": "F", "initials": "F"}, {"family": "Rosvall", "given": "M", "initials": "M"}], "type": "journal article", "published": "2022-11-02", "journal": {"title": "Vaccine", "issn": "1873-2518", "volume": "40", "issue": "46", "pages": "6640-6648", "issn-l": null}, "abstract": "Studies on sociodemographic disparities in Covid-19 vaccination uptake in the general population are still limited and mostly focused on older adults. This study examined sociodemographic differences in Covid-19 vaccination uptake in the total Swedish population aged 18-64 years.\n\nNational Swedish register data within the SCIFI-PEARL project were used to cross-sectionally investigate sociodemographic differences in Covid-19 vaccination among Swedish adults aged 18-64 years (n = 5,987,189) by 12 October 2021. Using logistic regression models, analyses were adjusted for sociodemographic factors, region of residence, history of Covid-19, and comorbidities. An intersectional analysis approach including several cross-classified subgroups was used to further address the complexity of sociodemographic disparities in vaccination uptake.\n\nBy 12 October 2021, 76\u00b70% of the Swedish population 18-64 years old had received at least two doses of Covid-19 vaccine, an additional 5\u00b75% had received only one dose, and 18\u00b75% were non-vaccinated. Non-vaccinated individuals were, compared to vaccinated, more often younger, male, had a lower income, were not gainfully employed, and/or were born outside Sweden. The social patterning for vaccine dose two was similar, but weaker, than for dose one. After multivariable adjustments, findings remained but were attenuated indicating the need to consider different sociodemographic factors simultaneously. The intersectional analysis showed a large variation in vaccine uptake ranging from 32% to 96% in cross-classified subgroups, reflecting considerable sociodemographic heterogeneity in vaccination coverage.\n\nOur study, addressing the entire Swedish population aged 18-64 years, showed broad sociodemographic disparities in Covid-19 vaccine uptake but also wide heterogeneities in coverage. The intersectional analysis approach indicates that focusing on specific sociodemographic factors in isolation and group average risks without considering the heterogeneity within such groups will risk missing the full variability of vaccine coverage.\n\nSciLifeLab / Knut & Alice Wallenberg Foundation, Swedish Research Council, Swedish government ALF agreement, FORMAS.", "doi": "10.1016/j.vaccine.2022.09.065", "pmid": "36210254", "labels": {"Research Area: Vaccine": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Public Health": null, "Category: Health": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC9515344"}, {"db": "pii", "key": "S0264-410X(22)01186-0"}], "notes": [], "created": "2022-11-29T14:27:27.622Z", "modified": "2022-11-29T14:27:27.626Z"}, {"entity": "publication", "iuid": "c3ab49fa7c1c4adeae09264231eff500", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3ab49fa7c1c4adeae09264231eff500.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3ab49fa7c1c4adeae09264231eff500"}}, "title": "Updated Results of the COVID-19 in MS Global Data Sharing Initiative: Anti-CD20 and Other Risk Factors Associated With COVID-19 Severity.", "authors": [{"family": "Simpson-Yap", "given": "Steve", "initials": "S"}, {"family": "Pirmani", "given": "Ashkan", "initials": "A"}, {"family": "Kalincik", "given": "Tomas", "initials": "T"}, {"family": "De Brouwer", "given": "Edward", "initials": "E"}, {"family": "Geys", "given": "Lotte", "initials": "L"}, {"family": "Parciak", "given": "Tina", "initials": "T"}, {"family": "Helme", "given": "Anne", "initials": "A"}, {"family": "Rijke", "given": "Nick", "initials": "N"}, {"family": "Hillert", "given": "Jan A", "initials": "JA"}, {"family": "Moreau", "given": "Yves", "initials": "Y"}, {"family": "Edan", "given": "Gilles", "initials": "G"}, {"family": "Sharmin", "given": "Sifat", "initials": "S"}, {"family": "Spelman", "given": "Tim", "initials": "T"}, {"family": "McBurney", "given": "Robert", "initials": "R"}, {"family": "Schmidt", "given": "Hollie", "initials": "H"}, {"family": "Bergmann", "given": "Arnfin B", "initials": "AB"}, {"family": "Braune", "given": "Stefan", "initials": "S"}, {"family": "Stahmann", "given": "Alexander", "initials": "A"}, {"family": "Middleton", "given": "Rod M", "initials": "RM"}, {"family": "Salter", "given": "Amber", "initials": "A"}, {"family": "Bebo", "given": "Bruce", "initials": "B"}, {"family": "Van der Walt", "given": "Anneke", "initials": "A"}, {"family": "Butzkueven", "given": "Helmut", "initials": "H"}, {"family": "Ozakbas", "given": "Serkan", "initials": "S"}, {"family": "Boz", "given": "Cavit", "initials": "C"}, {"family": "Karabudak", "given": "Rana", "initials": "R"}, {"family": "Alroughani", "given": "Raed", "initials": "R"}, {"family": "Rojas", "given": "Juan I", "initials": "JI"}, {"family": "van der Mei", "given": "Ingrid A", "initials": "IA"}, {"family": "Sciascia do Olival", "given": "Guilherme", "initials": "G"}, {"family": "Magyari", "given": "Melinda", "initials": "M"}, {"family": "Alonso", "given": "Ricardo N", "initials": "RN"}, {"family": "Nicholas", "given": "Richard S", "initials": "RS"}, {"family": "Chertcoff", "given": "Anibal S", "initials": "AS"}, {"family": "de Torres", "given": "Ana Zabalza", "initials": "AZ"}, {"family": "Arrambide", "given": "Georgina", "initials": "G"}, {"family": "Nag", "given": "Nupur", "initials": "N"}, {"family": "Descamps", "given": "Annabel", "initials": "A"}, {"family": "Costers", "given": "Lars", "initials": "L"}, {"family": "Dobson", "given": "Ruth", "initials": "R"}, {"family": "Miller", "given": "Aleisha", "initials": "A"}, {"family": "Rodrigues", "given": "Paulo", "initials": "P"}, {"family": "Pr\u010dkovska", "given": "Vesna", "initials": "V"}, {"family": "Comi", "given": "Giancarlo", "initials": "G"}, {"family": "Peeters", "given": "Liesbet M", "initials": "LM"}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "Neurol Neuroimmunol Neuroinflamm", "issn": "2332-7812", "volume": "9", "issue": "6", "pages": "e200021", "issn-l": null}, "abstract": "Certain demographic and clinical characteristics, including the use of some disease-modifying therapies (DMTs), are associated with severe acute respiratory syndrome coronavirus 2 infection severity in people with multiple sclerosis (MS). Comprehensive exploration of these relationships in large international samples is needed.\n\nClinician-reported demographic/clinical data from 27 countries were aggregated into a data set of 5,648 patients with suspected/confirmed coronavirus disease 2019 (COVID-19). COVID-19 severity outcomes (hospitalization, admission to intensive care unit [ICU], requiring artificial ventilation, and death) were assessed using multilevel mixed-effects ordered probit and logistic regression, adjusted for age, sex, disability, and MS phenotype. DMTs were individually compared with glatiramer acetate, and anti-CD20 DMTs with pooled other DMTs and with natalizumab.\n\nOf 5,648 patients, 922 (16.6%) with suspected and 4,646 (83.4%) with confirmed COVID-19 were included. Male sex, older age, progressive MS, and higher disability were associated with more severe COVID-19. Compared with glatiramer acetate, ocrelizumab and rituximab were associated with higher probabilities of hospitalization (4% [95% CI 1-7] and 7% [95% CI 4-11]), ICU/artificial ventilation (2% [95% CI 0-4] and 4% [95% CI 2-6]), and death (1% [95% CI 0-2] and 2% [95% CI 1-4]) (predicted marginal effects). Untreated patients had 5% (95% CI 2-8), 3% (95% CI 1-5), and 1% (95% CI 0-3) higher probabilities of the 3 respective levels of COVID-19 severity than glatiramer acetate. Compared with pooled other DMTs and with natalizumab, the associations of ocrelizumab and rituximab with COVID-19 severity were also more pronounced. All associations persisted/enhanced on restriction to confirmed COVID-19.\n\nAnalyzing the largest international real-world data set of people with MS with suspected/confirmed COVID-19 confirms that the use of anti-CD20 medication (both ocrelizumab and rituximab), as well as male sex, older age, progressive MS, and higher disability are associated with more severe course of COVID-19.", "doi": "10.1212/NXI.0000000000200021", "pmid": "36038263", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9423711"}, {"db": "pii", "key": "9/6/e200021"}], "notes": [], "created": "2022-10-07T12:45:50.749Z", "modified": "2023-06-19T14:41:09.696Z"}, {"entity": "publication", "iuid": "863172b33d8c41d79b4bd9b33c12cb9a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/863172b33d8c41d79b4bd9b33c12cb9a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/863172b33d8c41d79b4bd9b33c12cb9a"}}, "title": "The association between pre-exposure to glucocorticoids and other immunosuppressant drugs with severe COVID-19 outcomes.", "authors": [{"family": "Brodin", "given": "Rakel", "initials": "R"}, {"family": "van der Werff", "given": "Suzannes Desir\u00e9e", "initials": "SD"}, {"family": "Hedberg", "given": "Pontus", "initials": "P"}, {"family": "F\u00e4rnert", "given": "Anna", "initials": "A"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Requena-M\u00e9ndez", "given": "Ana", "initials": "A"}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "Clin Microbiol Infect", "issn": "1469-0691", "volume": "28", "issue": "11", "pages": "1477-1485", "issn-l": null}, "abstract": "Whether preinfection use of immunosuppressant drugs is associated with COVID-19 severity remains unclear. The study was aimed to determine the association between preinfection use of immunosuppressant drugs with COVID-19 outcomes within 1 month after COVID-19 diagnosis.\n\nThis cohort study included individuals aged \u226518 years with underlying conditions associated with an immunocompromised state and diagnosed with COVID-19 between February 2020 and January 2021 at Karolinska University Hospital, Stockholm. Exposure to immunosuppressant drugs was defined based on dose and duration of drugs (glucocorticoids and drugs included in L01 or L04 chapter of Anatomical Therapeutic Chemical classification) before COVID-19 diagnosis. Outcomes included hospital admission, ICU admission, mechanical ventilation, mortality, renal failure, stroke, pulmonary embolism, and cardiac event. ORs were calculated using logistic regression and baseline covariate adjustment for confounding with inverse probability of treatment weights.\n\nOf 1067 included individuals, 444 were pre-exposed to immunosuppressive treatments before COVID-19 diagnosis (72 high-dose glucocorticoids, 255 L01 drugs (antineoplastics), 198 L04 (other immunosuppressants) and 78 to multiple drugs). There was no association between pre-exposure and hospital admission (OR 0.83, 95% CI 0.64 to 1.09) because of COVID-19. Pre-exposure to L01 or L04 drugs were not associated with hospital admission (adjusted ORs (aORs): 1.23, 0.86 to 1.76 and 1.31, 0.77 to 2.21) or other outcomes. High-dose glucocorticoids (\u226520 mg/day prednisolone equivalent) were associated with hospital admission (aOR 2.50, 1.26 to 4.96), cardiac events (aOR 1.93, 1.08 to 3.46), pulmonary embolism (aOR 2.78, 1.08 to 7.15), and mortality (aOR 3.48, 1.77 to 6.86) due to COVID-19.\n\nAntineoplastic and other immunosuppressants drugs were not associated with COVID-19 severity whereas high-dose glucocorticoids were associated. Further studies should evaluate the effect of pre-exposure of different dose of glucocorticoids on COVID-19 prognosis.", "doi": "10.1016/j.cmi.2022.05.014", "pmid": "35644344", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(22)00270-1"}, {"db": "pmc", "key": "PMC9135501"}], "notes": [], "created": "2022-06-21T17:35:23.959Z", "modified": "2022-10-31T17:26:54.979Z"}, {"entity": "publication", "iuid": "e2ff0bac268343ce8899e4948cf73082", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2ff0bac268343ce8899e4948cf73082.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2ff0bac268343ce8899e4948cf73082"}}, "title": "Patients' perspectives on the effect of the COVID-19 pandemic on access to cancer care and social contacts in Sweden and the UK: a cross-sectional study.", "authors": [{"family": "Edlund", "given": "Karolina", "initials": "K", "orcid": "0000-0003-2349-0076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8004580e2964f19aa44dca6399e4f84.json"}}, {"family": "Dahlstr\u00f6m", "given": "Lisen Arnheim", "initials": "LA", "orcid": "0000-0003-3926-9616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f5cf51d7b8e49cebe5e3743cb7ae71a.json"}}, {"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM", "orcid": "0000-0002-3912-1171", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f69d74b370764e2e93f8c98eca79e064.json"}}, {"family": "van der Kop", "given": "Mia L", "initials": "ML", "orcid": "0000-0002-5590-6833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b5c278a602240feb8953d0c02c029a0.json"}}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "Support Care Cancer", "issn": "1433-7339", "volume": "30", "issue": "11", "pages": "9101-9108", "issn-l": null}, "abstract": "We aimed to determine whether there was a difference in access to cancer-related healthcare between people living in Sweden and the United Kingdom (UK) during the COVID-19 pandemic. We also describe how the pandemic affected social contact of patients undergoing treatment.\n\nThis cross-sectional study used survey data collected through the War on Cancer mobile phone application between September 5, 2020, and January 6, 2021. We included individuals with cancer diagnoses living in Sweden or the UK. The association between difficulty accessing cancer-related healthcare and country was examined using logistic regression. Frequencies were used to describe the effect of the pandemic on social contact.\n\nOf 491 individuals included in the study, 183 were living in the UK and 308 in Sweden. Living in the UK was associated with greater difficulty accessing cancer-related healthcare (n = 99/183, 54.1%) than living in Sweden (n = 100/308, 32.5%) (odds ratio 2.12, 95% CI 1.39-3.23, p < 0.001). The pandemic affected social contact for almost all patients (n = 218/238, 91.6%) undergoing treatment.\n\nThis study highlights the differential impact that the pandemic may have had on patients' access to cancer-related care in the UK and Sweden. In both countries, the pandemic overwhelmingly affected social contact of individuals undergoing cancer treatment. New ways must be found to improve access to cancer-related care and reduce social isolation for patients with cancer during a pandemic.", "doi": "10.1007/s00520-022-07298-7", "pmid": "35984510", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9388965"}, {"db": "pii", "key": "10.1007/s00520-022-07298-7"}], "notes": [], "created": "2022-09-12T18:46:25.822Z", "modified": "2023-01-13T14:44:07.641Z"}, {"entity": "publication", "iuid": "59c5bb6eb35c4aabab0136466bd3af1e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/59c5bb6eb35c4aabab0136466bd3af1e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/59c5bb6eb35c4aabab0136466bd3af1e"}}, "title": "IL-6 signalling biomarkers in hospitalised patients with moderate to severe SARS-CoV-2 infection in a single centre study in Sweden.", "authors": [{"family": "Ziegler", "given": "Louise", "initials": "L"}, {"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Gigante", "given": "Bruna", "initials": "B"}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "Cytokine", "issn": "1043-4666", "issn-l": null, "volume": "159", "issue": null, "pages": "156020"}, "abstract": "COVID-19 disease severity and need for intensive care has been associated with profound immune disturbances in which interleukin 6 (IL-6) is central. IL-6 signals through two pathways: classical IL-6 signalling with C-reactive protein (CRP) as a product is pivotal in the acute immune response against pathogens while IL-6 trans-signalling is involved in prolonged inflammation. We measured biomarkers of the IL-6 classical and trans-signalling pathways in patients with moderate or severe COVID-19 in the first wave of the COVID-19 pandemic.\r\n\r\nIn a longitudinal cohort study including patients admitted to Danderyd hospital, Stockholm, Sweden, with COVID-19 (n = 112), plasma IL-6 mirroring activity in both pathways, CRP as marker of classical signalling and the soluble IL-6 receptor (sIL-6R) and soluble glycoprotein 130 (sgp130) as markers of trans-signalling were analysed at baseline. Potential differences in biomarker levels between groups of moderate and severe COVID-19 defined by care level, level of respiratory support and one-month mortality was analysed, as was correlations between biomarkers. In addition, levels 4 months after hospital admission were compared to those at baseline.\r\n\r\nLevels of IL-6 and CRP were increased in severe COVID-19 whereas IL-6 trans-signalling markers (sIL-6R, sgp130) did not differ between the groups. CRP correlated positively with IL-6 in all patients while correlation with IL-6 could not be demonstrated for sIL-6R and sgp130 in either group. Levels of IL-6, CRP and sIL-6R were significantly decreased after 4 months whereas sgp130 levels increased.\r\n\r\nClassical signalling is the dominating IL-6 pathway in moderate-severe COVID-19.", "doi": "10.1016/j.cyto.2022.156020", "pmid": "36057230", "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "S1043-4666(22)00229-0"}, {"db": "pmc", "key": "PMC9420722"}], "notes": [], "created": "2022-10-13T13:23:08.582Z", "modified": "2022-10-13T14:37:36.652Z"}, {"entity": "publication", "iuid": "c52dd95381fc49d9a6ea4aab11fd7674", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c52dd95381fc49d9a6ea4aab11fd7674.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c52dd95381fc49d9a6ea4aab11fd7674"}}, "title": "Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative.", "authors": [{"family": "Butler-Laporte", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-5388-0396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/529dc69151d3463e8480b975d70fa759.json"}}, {"family": "Povysil", "given": "Gundula", "initials": "G", "orcid": "0000-0003-4625-5909", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/658ac11ede214c9383221afb2d0b5ab1.json"}}, {"family": "Kosmicki", "given": "Jack A", "initials": "JA", "orcid": "0000-0003-1252-6192", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d39c52fe05574c1e90ca5f7e2daa921f.json"}}, {"family": "Cirulli", "given": "Elizabeth T", "initials": "ET", "orcid": "0000-0001-7808-2809", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/da51a8befd454b03b5bf8c50ca1835dd.json"}}, {"family": "Drivas", "given": "Theodore", "initials": "T", "orcid": "0000-0002-8717-0111", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c6643db2e4b4f92abf8a6b53c0d746a.json"}}, {"family": "Furini", "given": "Simone", "initials": "S"}, {"family": "Saad", "given": "Chadi", "initials": "C", "orcid": "0000-0001-6963-9126", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5636bfebba7144e7b729051d07f873ca.json"}}, {"family": "Schmidt", "given": "Axel", "initials": "A"}, {"family": "Olszewski", "given": "Pawel", "initials": "P", "orcid": "0000-0003-1010-8843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89b5f8798556430b867d8fcc5c2afbc6.json"}}, {"family": "Korotko", "given": "Urszula", "initials": "U", "orcid": "0000-0002-1779-8368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37a3dcefa2ca465cb9f3682f76ab5b83.json"}}, {"family": "Quinodoz", "given": "Mathieu", "initials": "M", "orcid": "0000-0002-9841-4433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41616c1f1c294ef585b140d8ee01434d.json"}}, {"family": "\u00c7elik", "given": "Elifnaz", "initials": "E", "orcid": "0000-0002-0324-5228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/043ad752eb754eb29107ebaff6a347c3.json"}}, {"family": "Kundu", "given": "Kousik", "initials": "K", "orcid": "0000-0002-1019-8351", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/775583a7e98545f1a4c5d1b2a94252b6.json"}}, {"family": "Walter", "given": "Klaudia", "initials": "K", "orcid": "0000-0003-4448-0301", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6e8e60bb41e40b399e86ee055bababd.json"}}, {"family": "Jung", "given": "Junghyun", "initials": "J"}, {"family": "Stockwell", "given": "Amy D", "initials": "AD"}, {"family": "Sloofman", "given": "Laura G", "initials": "LG", "orcid": "0000-0001-7628-4378", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/853b4f1cc0b04ed29fa07edb075688bc.json"}}, {"family": "Jordan", "given": "Daniel M", "initials": "DM", "orcid": "0000-0002-5318-8225", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/431bea0f7dbd46b0a60752f575783309.json"}}, {"family": "Thompson", "given": "Ryan C", "initials": "RC", "orcid": "0000-0002-0450-8181", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/acb45eb3b27e4b9191ddacfb0089321f.json"}}, {"family": "Del Valle", "given": "Diane", "initials": "D", "orcid": "0000-0001-6983-5362", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e9483a880d04872a10d52d4eb928e65.json"}}, {"family": "Simons", "given": "Nicole", "initials": "N", "orcid": "0000-0002-3952-1458", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a55f0ff0effc4d02b5ccb0a056b89936.json"}}, {"family": "Cheng", "given": "Esther", "initials": "E"}, {"family": "Sebra", "given": "Robert", "initials": "R"}, {"family": "Schadt", "given": "Eric E", "initials": "EE"}, {"family": "Kim-Schulze", "given": "Seunghee", "initials": "S"}, {"family": "Gnjatic", "given": "Sacha", "initials": "S"}, {"family": "Merad", "given": "Miriam", "initials": "M"}, {"family": "Buxbaum", "given": "Joseph D", "initials": "JD"}, {"family": "Beckmann", "given": "Noam D", "initials": "ND"}, {"family": "Charney", "given": "Alexander W", "initials": "AW"}, {"family": "Przychodzen", "given": "Bartlomiej", "initials": "B"}, {"family": "Chang", "given": "Timothy", "initials": "T", "orcid": "0000-0002-9225-9874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3bbf7182b1949eaaa49a64ca6b1946d.json"}}, {"family": "Pottinger", "given": "Tess D", "initials": "TD"}, {"family": "Shang", "given": "Ning", "initials": "N"}, {"family": "Brand", "given": "Fabian", "initials": "F", "orcid": "0000-0003-1885-7021", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3746b2b297d1475fbf6f40c0a0956bc6.json"}}, {"family": "Fava", "given": "Francesca", "initials": "F"}, {"family": "Mari", "given": "Francesca", "initials": "F"}, {"family": "Chwialkowska", "given": "Karolina", "initials": "K", "orcid": "0000-0001-8053-8959", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c03b0ca07f474484b9c6688e09ad9a1c.json"}}, {"family": "Niemira", "given": "Magdalena", "initials": "M", "orcid": "0000-0002-0701-4961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d67e7303fb3745a0bf8c606095670008.json"}}, {"family": "Pula", "given": "Szymon", "initials": "S", "orcid": "0000-0002-5684-5358", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5922e06d10574062ae4f2a8bea7ac407.json"}}, {"family": "Baillie", "given": "J Kenneth", "initials": "JK"}, {"family": "Stuckey", "given": "Alex", "initials": "A", "orcid": "0000-0001-8636-737X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f4f17b92dec479b8aa367a6e42cbb15.json"}}, {"family": "Salas", "given": "Antonio", "initials": "A"}, {"family": "Bello", "given": "Xabier", "initials": "X", "orcid": "0000-0002-4990-8496", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2dd3d12cbc884c8f811d94300bd67ebc.json"}}, {"family": "Pardo-Seco", "given": "Jacobo", "initials": "J"}, {"family": "G\u00f3mez-Carballa", "given": "Alberto", "initials": "A"}, {"family": "Rivero-Calle", "given": "Irene", "initials": "I"}, {"family": "Martin\u00f3n-Torres", "given": "Federico", "initials": "F"}, {"family": "Ganna", "given": "Andrea", "initials": "A"}, {"family": "Karczewski", "given": "Konrad J", "initials": "KJ", "orcid": "0000-0003-2878-4671", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/803dc14ee46c4c648056d01629e645c8.json"}}, {"family": "Veerapen", "given": "Kumar", "initials": "K"}, {"family": "Bourgey", "given": "Mathieu", "initials": "M", "orcid": "0000-0002-8432-834X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ed235e927a940d6a93a61be66137fec.json"}}, {"family": "Bourque", "given": "Guillaume", "initials": "G", "orcid": "0000-0002-3933-9656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7cf09c10c8d64159a13257ec588633c0.json"}}, {"family": "Eveleigh", "given": "Robert Jm", "initials": "RJ", "orcid": "0000-0002-4147-382X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3163112690e04d5abefa4f00b0d42948.json"}}, {"family": "Forgetta", "given": "Vincenzo", "initials": "V"}, {"family": "Morrison", "given": "David", "initials": "D", "orcid": "0000-0001-8380-3615", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6099e7b5999e486eb486bac1f455fdc1.json"}}, {"family": "Langlais", "given": "David", "initials": "D", "orcid": "0000-0003-4429-0110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6c1d5ffed164e62897e5df85e398629.json"}}, {"family": "Lathrop", "given": "Mark", "initials": "M"}, {"family": "Mooser", "given": "Vincent", "initials": "V", "orcid": "0000-0002-8632-0448", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7af40c95aeaf4dd7ab639b31f773b89a.json"}}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T", "orcid": "0000-0001-9510-5646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd273e50091d44c3b3e8d1473ce89b0a.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Marincevic-Zuniga", "given": "Yanara", "initials": "Y"}, {"family": "Nordlund", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8699-9959", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/63952dae96884221862363826c33746d.json"}}, {"family": "Schiabor Barrett", "given": "Kelly M", "initials": "KM", "orcid": "0000-0001-6194-787X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea0e8ac97dcf4591b579c2eae23ff5e9.json"}}, {"family": "Lee", "given": "William", "initials": "W"}, {"family": "Bolze", "given": "Alexandre", "initials": "A", "orcid": "0000-0001-7399-2766", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45c4e714f3054be69533f8d87f686485.json"}}, {"family": "White", "given": "Simon", "initials": "S", "orcid": "0000-0001-6375-2363", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d73512e150e04226b9862d24daa9c4fb.json"}}, {"family": "Riffle", "given": "Stephen", "initials": "S"}, {"family": "Tanudjaja", "given": "Francisco", "initials": "F"}, {"family": "Sandoval", "given": "Efren", "initials": "E"}, {"family": "Neveux", "given": "Iva", "initials": "I"}, {"family": "Dabe", "given": "Shaun", "initials": "S", "orcid": "0000-0002-2494-962X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d819354f7ed4d30b2d1df61905c9091.json"}}, {"family": "Casadei", "given": "Nicolas", "initials": "N", "orcid": "0000-0003-2209-0580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/413e813f99f8432e982e8849e446a716.json"}}, {"family": "Motameny", "given": "Susanne", "initials": "S", "orcid": "0000-0003-1186-1108", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db935de3e5b44cd99512cfb6342c8214.json"}}, {"family": "Alaamery", "given": "Manal", "initials": "M"}, {"family": "Massadeh", "given": "Salam", "initials": "S", "orcid": "0000-0001-9193-0008", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3214967d998b47c0bc9662c4b1157b2b.json"}}, {"family": "Aljawini", "given": "Nora", "initials": "N"}, {"family": "Almutairi", "given": "Mansour S", "initials": "MS", "orcid": "0000-0003-2736-8991", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51120e073f95436399117a8a0f568de1.json"}}, {"family": "Arabi", "given": "Yaseen M", "initials": "YM", "orcid": "0000-0001-5735-6241", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52d3898b4fb44f53b7d80475874d4894.json"}}, {"family": "Alqahtani", "given": "Saleh A", "initials": "SA"}, {"family": "Al Harthi", "given": "Fawz S", "initials": "FS"}, {"family": "Almutairi", "given": "Amal", "initials": "A"}, {"family": "Alqubaishi", "given": "Fatima", "initials": "F"}, {"family": "Alotaibi", "given": "Sarah", "initials": "S"}, {"family": "Binowayn", "given": "Albandari", "initials": "A"}, {"family": "Alsolm", "given": "Ebtehal A", "initials": "EA"}, {"family": "El Bardisy", "given": "Hadeel", "initials": "H"}, {"family": "Fawzy", "given": "Mohammad", "initials": "M", "orcid": "0000-0002-1318-9979", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6fe7222738b54cb09fce2d5128dcb393.json"}}, {"family": "Cai", "given": "Fang", "initials": "F"}, {"family": "Soranzo", "given": "Nicole", "initials": "N"}, {"family": "Butterworth", "given": "Adam", "initials": "A"}, {"family": "COVID-19 Host Genetics Initiative", "given": "", "initials": ""}, {"family": "DeCOI Host Genetics Group", "given": "", "initials": ""}, {"family": "GEN-COVID Multicenter Study (Italy)", "given": "", "initials": ""}, {"family": "Mount Sinai Clinical Intelligence Center", "given": "", "initials": ""}, {"family": "GEN-COVID consortium (Spain)", "given": "", "initials": ""}, {"family": "GenOMICC Consortium", "given": "", "initials": ""}, {"family": "Japan COVID-19 Task Force", "given": "", "initials": ""}, {"family": "Regeneron Genetics Center", "given": "", "initials": ""}, {"family": "Geschwind", "given": "Daniel H", "initials": "DH"}, {"family": "Arteaga", "given": "Stephanie", "initials": "S", "orcid": "0000-0003-1441-8849", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/652a5da6ce8e4c9bbfdbfe8f11768938.json"}}, {"family": "Stephens", "given": "Alexis", "initials": "A", "orcid": "0000-0002-5979-6838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/249f5a87985a463ab89b8f6f1022d829.json"}}, {"family": "Butte", "given": "Manish J", "initials": "MJ"}, {"family": "Boutros", "given": "Paul C", "initials": "PC"}, {"family": "Yamaguchi", "given": "Takafumi N", "initials": "TN", "orcid": "0000-0003-1082-3871", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac413398e38e48e4bb9f5b94cbf99a11.json"}}, {"family": "Tao", "given": "Shu", "initials": "S"}, {"family": "Eng", "given": "Stefan", "initials": "S", "orcid": "0000-0002-5245-6507", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d618fa1da8142b3bc9a30a86b0b4d1a.json"}}, {"family": "Sanders", "given": "Timothy", "initials": "T"}, {"family": "Tung", "given": "Paul J", "initials": "PJ"}, {"family": "Broudy", "given": "Michael E", "initials": "ME"}, {"family": "Pan", "given": "Yu", "initials": "Y"}, {"family": "Gonzalez", "given": "Alfredo", "initials": "A", "orcid": "0000-0001-8963-3135", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/331f872ae2894743b97ff14504d0324f.json"}}, {"family": "Chavan", "given": "Nikhil", "initials": "N"}, {"family": "Johnson", "given": "Ruth", "initials": "R", "orcid": "0000-0002-1929-0998", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77d872b3614a484dbabd0a66cf12c73a.json"}}, {"family": "Pasaniuc", "given": "Bogdan", "initials": "B"}, {"family": "Yaspan", "given": "Brian", "initials": "B", "orcid": "0000-0002-3787-2510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aaf6d84f442e4b09be17a2b0639db758.json"}}, {"family": "Smieszek", "given": "Sandra", "initials": "S", "orcid": "0000-0002-8006-0454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df8cabc7e6c543d880de72e68357e1b4.json"}}, {"family": "Rivolta", "given": "Carlo", "initials": "C", "orcid": "0000-0002-0733-9950", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91f3a7aa91a64175880dcc3c2e615c11.json"}}, {"family": "Bibert", "given": "Stephanie", "initials": "S"}, {"family": "Bochud", "given": "Pierre-Yves", "initials": "PY", "orcid": "0000-0002-2208-4757", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae5a5781ed614965b039e94739bf7a6a.json"}}, {"family": "Dabrowski", "given": "Maciej", "initials": "M", "orcid": "0000-0003-4150-3985", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a678606a0aa340559fe7916f806af31b.json"}}, {"family": "Zawadzki", "given": "Pawel", "initials": "P", "orcid": "0000-0002-9032-2315", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7695a8653b4e4b878878179e87bc9cc3.json"}}, {"family": "Sypniewski", "given": "Mateusz", "initials": "M"}, {"family": "Kaja", "given": "El\u017cbieta", "initials": "E", "orcid": "0000-0003-1277-6140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb9f22b55cae4da1834f8c3bfb741b59.json"}}, {"family": "Chariyavilaskul", "given": "Pajaree", "initials": "P", "orcid": "0000-0003-1096-6020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/beb2b4f73a5a410891031c2afe2fd6a4.json"}}, {"family": "Nilaratanakul", "given": "Voraphoj", "initials": "V", "orcid": "0000-0002-3964-5477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2ac1d215e144f699c8e5787a90df3cd.json"}}, {"family": "Hirankarn", "given": "Nattiya", "initials": "N", "orcid": "0000-0003-2224-6856", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9073cb795dd4839aa2cda851ba84000.json"}}, {"family": "Shotelersuk", "given": "Vorasuk", "initials": "V", "orcid": "0000-0002-1856-0589", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56f21402edbc4312aa672bf78f0dae0d.json"}}, {"family": "Pongpanich", "given": "Monnat", "initials": "M", "orcid": "0000-0003-3228-3351", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9051b469fa614e62a7b10d4e6ea2db86.json"}}, {"family": "Phokaew", "given": "Chureerat", "initials": "C", "orcid": "0000-0002-4246-2604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2be4f5c04e004ed9a6c61f2d47b0a101.json"}}, {"family": "Chetruengchai", "given": "Wanna", "initials": "W", "orcid": "0000-0003-2495-6595", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78faacad098041d4a386cce12d17c840.json"}}, {"family": "Tokunaga", "given": "Katsushi", "initials": "K"}, {"family": "Sugiyama", "given": "Masaya", "initials": "M", "orcid": "0000-0002-9084-7197", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/834495fe76c64a05a17f430dce9ad007.json"}}, {"family": "Kawai", "given": "Yosuke", "initials": "Y", "orcid": "0000-0003-0666-1224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33862e88b2774937a071237159822561.json"}}, {"family": "Hasegawa", "given": "Takanori", "initials": "T", "orcid": "0000-0001-7251-9950", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/342adeed9885409dbedc94c991dccd3e.json"}}, {"family": "Naito", "given": "Tatsuhiko", "initials": "T"}, {"family": "Namkoong", "given": "Ho", "initials": "H", "orcid": "0000-0001-6181-4284", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cf9a27fc9a6409990b1c5871bdddc90.json"}}, {"family": "Edahiro", "given": "Ryuya", "initials": "R"}, {"family": "Kimura", "given": "Akinori", "initials": "A"}, {"family": "Ogawa", "given": "Seishi", "initials": "S"}, {"family": "Kanai", "given": "Takanori", "initials": "T"}, {"family": "Fukunaga", "given": "Koichi", "initials": "K"}, {"family": "Okada", "given": "Yukinori", "initials": "Y"}, {"family": "Imoto", "given": "Seiya", "initials": "S"}, {"family": "Miyano", "given": "Satoru", "initials": "S", "orcid": "0000-0002-1753-6616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec9d5bbdbac34335906afc0dede1a0df.json"}}, {"family": "Mangul", "given": "Serghei", "initials": "S", "orcid": "0000-0003-4770-3443", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dbe15e382e84d38a0fd859377e39d47.json"}}, {"family": "Abedalthagafi", "given": "Malak S", "initials": "MS"}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ee1510080704cf6a2a6972deb94123f.json"}}, {"family": "Grzymski", "given": "Joseph J", "initials": "JJ", "orcid": "0000-0003-2646-8958", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/212250cafa7b4966914ad7455303c2be.json"}}, {"family": "Washington", "given": "Nicole L", "initials": "NL"}, {"family": "Ossowski", "given": "Stephan", "initials": "S", "orcid": "0000-0002-7416-9568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37310c6c082042b8a743635afd381644.json"}}, {"family": "Ludwig", "given": "Kerstin U", "initials": "KU", "orcid": "0000-0002-8541-2519", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02922a1f71c64a8e9dc6aa1c29a20270.json"}}, {"family": "Schulte", "given": "Eva C", "initials": "EC", "orcid": "0000-0003-3105-5672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b02ec0962cdc4e15853c4a3aeba4992d.json"}}, {"family": "Riess", "given": "Olaf", "initials": "O"}, {"family": "Moniuszko", "given": "Marcin", "initials": "M"}, {"family": "Kwasniewski", "given": "Miroslaw", "initials": "M"}, {"family": "Mbarek", "given": "Hamdi", "initials": "H"}, {"family": "Ismail", "given": "Said I", "initials": "SI"}, {"family": "Verma", "given": "Anurag", "initials": "A", "orcid": "0000-0002-5063-9107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ce606e23fdc4de8865ebb196fde5601.json"}}, {"family": "Goldstein", "given": "David B", "initials": "DB", "orcid": "0000-0001-7627-0259", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5954b96aeb15472bb7bc014760f1ba0b.json"}}, {"family": "Kiryluk", "given": "Krzysztof", "initials": "K", "orcid": "0000-0002-5047-6715", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d1362394dec4a7e934fd6c79ad94df3.json"}}, {"family": "Renieri", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-0846-9220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6388ba45f89d4c3b94c4c6c88f97cadb.json"}}, {"family": "Ferreira", "given": "Manuel A R", "initials": "MAR"}, {"family": "Richards", "given": "J Brent", "initials": "JB", "orcid": "0000-0002-3746-9086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8994152547ee4765b1653b834c52a21a.json"}}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "PLoS Genet", "issn": "1553-7404", "volume": "18", "issue": "11", "pages": "e1010367", "issn-l": null}, "abstract": "Host genetics is a key determinant of COVID-19 outcomes. Previously, the COVID-19 Host Genetics Initiative genome-wide association study used common variants to identify multiple loci associated with COVID-19 outcomes. However, variants with the largest impact on COVID-19 outcomes are expected to be rare in the population. Hence, studying rare variants may provide additional insights into disease susceptibility and pathogenesis, thereby informing therapeutics development. Here, we combined whole-exome and whole-genome sequencing from 21 cohorts across 12 countries and performed rare variant exome-wide burden analyses for COVID-19 outcomes. In an analysis of 5,085 severe disease cases and 571,737 controls, we observed that carrying a rare deleterious variant in the SARS-CoV-2 sensor toll-like receptor TLR7 (on chromosome X) was associated with a 5.3-fold increase in severe disease (95% CI: 2.75-10.05, p = 5.41x10-7). This association was consistent across sexes. These results further support TLR7 as a genetic determinant of severe disease and suggest that larger studies on rare variants influencing COVID-19 outcomes could provide additional insights.", "doi": "10.1371/journal.pgen.1010367", "pmid": "36327219", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9632827"}, {"db": "pii", "key": "PGENETICS-D-22-00434"}, {"db": "URL", "key": "https://github.com/DrGBL/WES.WGS", "description": "https://github.com/DrGBL/WES.WGS"}], "notes": [], "created": "2022-11-29T16:14:29.516Z", "modified": "2022-11-29T16:15:32.496Z"}, {"entity": "publication", "iuid": "6d229c4662244bc9a1951205596cb20c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6d229c4662244bc9a1951205596cb20c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6d229c4662244bc9a1951205596cb20c"}}, "title": "COVID-19 Information in Sweden: Opinions of Immigrants with Limited Proficiency in Swedish.", "authors": [{"family": "Roble", "given": "Sagal", "initials": "S"}, {"family": "W\u00e5ngdahl", "given": "Josefin", "initials": "J"}, {"family": "Warner", "given": "Georgina", "initials": "G", "orcid": "0000-0002-7850-9136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a44058151a6c4ff4be148921ad1e9e57.json"}}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "Health Commun", "issn": "1532-7027", "volume": "37", "issue": "12", "pages": "1510-1519", "issn-l": null}, "abstract": "COVID-19 has highlighted the importance of health information for prevention of communicable disease. Knowledge about groups that have high risk is important to prevent disease transmission. In Sweden, immigrants have been identified as one such group. Yet, little is known about where they have sourced information about COVID-19 and their opinions toward it. The aim of this study was to describe the COVID-19 information sources used by immigrants with limited proficiency in Swedish as well as their opinions on how comprehensive the information has been, the importance of the recommendations and their possibility to follow them. A cross-sectional survey was conducted via introductory Swedish language classes in Region Uppsala (n = 855). The results showed the immigrants were using different information sources, with the majority using school, media and social media. The immigrants' opinions about COVID-19 information differed. Most reported they knew where to find information; however, over two-fifths reported the recommendations from the authorities should be more extensive. The majority reported it is important to follow the recommendations, whereas the possibility to follow the recommendations was more mixed. Age differences in opinions toward COVID-19 information were detected. Although the results were largely positive, there still appears to be a need for improvement in how immigrant groups with limited ability in the host country\u00b4s language are reached. Effective health communication that engages the whole nation is an important factor authorities should commit to as we face the current pandemic. This research suggests that an approach tailored by age could be helpful.", "doi": "10.1080/10410236.2022.2050005", "pmid": "35287507", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-01-13T13:25:27.113Z", "modified": "2023-01-13T13:25:27.159Z"}, {"entity": "publication", "iuid": "3ae9d08a217348928d2628f0596b0ff2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ae9d08a217348928d2628f0596b0ff2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ae9d08a217348928d2628f0596b0ff2"}}, "title": "B-cell repopulation dynamics and drug pharmacokinetics impact SARS-CoV-2 vaccine efficacy in anti-CD20-treated multiple sclerosis patients.", "authors": [{"family": "Asplund H\u00f6gelin", "given": "Klara", "initials": "K", "orcid": "0000-0002-3696-355X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e30a564a8ac14f97af8d46d222dff3ab.json"}}, {"family": "Ruffin", "given": "Nicolas", "initials": "N"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Starvaggi Cucuzza", "given": "Chiara", "initials": "C"}, {"family": "Khademi", "given": "Mohsen", "initials": "M"}, {"family": "Olsson", "given": "Tomas", "initials": "T"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Al Nimer", "given": "Faiez", "initials": "F"}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "Eur J Neurol", "issn": "1468-1331", "issn-l": null, "volume": "29", "issue": "11", "pages": "3317-3328"}, "abstract": "Recent findings document a blunted humoral response to SARS-CoV-2 vaccination in patients on anti-CD20 treatment. Although most patients develop a cellular response, it is still important to identify predictors of seroconversion to optimize vaccine responses.\n\nWe determined antibody responses after SARS-CoV-2 vaccination in a real-world cohort of multiple sclerosis patients (n = 94) treated with anti-CD20, mainly rituximab, with variable treatment duration (median = 2.9, range = 0.4-9.6 years) and time from last anti-CD20 infusion to vaccination (median = 190, range = 60-1032 days).\n\nWe find that presence of B cells and/or rituximab in blood predict seroconversion better than time since last infusion. Using multiple logistic regression, presence of >0.5% B cells increased probability of seroconversion with an odds ratio (OR) of 5.0 (95% confidence interval [CI] = 1.0-28.1, p = 0.055), whereas the corresponding OR for \u22656 months since last infusion was 1.45 (95% CI = 0.20-10.15, p = 0.705). In contrast, detectable rituximab levels were negatively associated with seroconversion (OR = 0.05, 95% CI = 0.002-0.392, p = 0.012). Furthermore, na\u00efve and memory IgG+ B cells correlated with antibody levels. Although retreatment with rituximab at 4 weeks or more after booster depleted spike-specific B cells, it did not noticeably affect the rate of decline in antibody titers. Interferon-\u03b3 and/or interleukin-13 T-cell responses to the spike S1 domain were observed in most patients, but with no correlation to spike antibody levels.\n\nThese findings are relevant for providing individualized guidance to patients and planning of vaccination schemes, in turn optimizing benefit-risk with anti-CD20.", "doi": "10.1111/ene.15492", "pmid": "35808856", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Vaccines": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Vaccine": null}, "xrefs": [{"db": "pmc", "key": "PMC9349816"}], "notes": [], "created": "2022-08-15T14:47:44.894Z", "modified": "2022-10-17T14:51:58.545Z"}, {"entity": "publication", "iuid": "66b4f38551804f02a4d51ce775bafc3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66b4f38551804f02a4d51ce775bafc3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66b4f38551804f02a4d51ce775bafc3d"}}, "title": "Differential Bias for Creatinine- and Cystatin C- Derived Estimated Glomerular Filtration Rate in Critical COVID-19.", "authors": [{"family": "Larsson", "given": "Anders O", "initials": "AO", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2be858ab604743b72383dfdcd14689.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Nyman", "given": "Ulf", "initials": "U"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Eriksson", "given": "Mats B", "initials": "MB", "orcid": "0000-0002-3178-4210", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c90375295094966a51f9d17c275abb6.json"}}], "type": "journal article", "published": "2022-10-26", "journal": {"title": "Biomedicines", "issn": "2227-9059", "volume": "10", "issue": "11", "issn-l": null}, "abstract": "COVID-19 is a systemic disease, frequently affecting kidney function. Dexamethasone is standard treatment in severe COVID-19 cases, and is considered to increase plasma levels of cystatin C. However, this has not been studied in COVID-19. Glomerular filtration rate (GFR) is a clinically important indicator of renal function, but often estimated using equations (eGFR) based on filtered metabolites. This study focuses on sources of bias for eGFRs (mL/min) using a creatinine-based equation (eGFRLMR) and a cystatin C-based equation (eGFRCAPA) in intensive-care-treated patients with COVID-19. This study was performed on 351 patients aged 18 years old or above with severe COVID-19 infections, admitted to the intensive care unit (ICU) in Uppsala University Hospital, a tertiary care hospital in Uppsala, Sweden, between 14 March 2020 and 10 March 2021. Dexamethasone treatment (6 mg for up to 10 days) was introduced 22 June 2020 (n = 232). Values are presented as medians (IQR). eGFRCAPA in dexamethasone-treated patients was 69 (37), and 74 (46) in patients not given dexamethasone (p = 0.01). eGFRLMR was not affected by dexamethasone. eGFRLMR in females was 94 (20), and 75 (38) in males (p = 0.00001). Age and maximal CRP correlated negatively to eGFRCAPA and eGFRLMR, whereas both eGFR equations correlated positively to BMI. In ICU patients with COVID-19, dexamethasone treatment was associated with reduced eGFRCAPA. This finding may be explained by corticosteroid-induced increases in plasma cystatin C. This observation is important from a clinical perspective since adequate interpretation of laboratory results is crucial.", "doi": "10.3390/biomedicines10112708", "pmid": "36359231", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "biomedicines10112708"}], "notes": [], "created": "2022-11-25T10:46:17.171Z", "modified": "2022-11-25T10:46:17.220Z"}, {"entity": "publication", "iuid": "fbe760843fc148f79d4d40761ba99f43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fbe760843fc148f79d4d40761ba99f43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fbe760843fc148f79d4d40761ba99f43"}}, "title": "Do Comorbidities and Daily Medication before SARS-CoV-2 Infection Play a Role in Self-Reported Post-Infection Symptoms?", "authors": [{"family": "Va\u017eg\u0117lien\u0117", "given": "Dovil\u0117", "initials": "D"}, {"family": "Kubilius", "given": "Raimondas", "initials": "R"}, {"family": "Bileviciute-Ljungar", "given": "Indre", "initials": "I"}], "type": "journal article", "published": "2022-10-25", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "11", "issue": "21", "issn-l": "2077-0383"}, "abstract": "This study investigated the associations between health status before SARS-CoV-2 infection and persistent symptoms after acute infection. Data were collected from participants older than 18 years and more than 28 days after acute SARS-CoV-2 infection using an online survey. Sociodemographic data, comorbidities, and daily medication before infection, as well as acute and persistent symptoms were analysed. Among the 1050 participants (mean age 41 years, 88% women, 56% with higher education, 93% working), 538 (51%) reported being healthy and 762 (73%) reported not taking any daily medication prior to infection. Positive laboratory testing was reported by 965 (92%) participants; asymptomatic infection was reported by 30 (3%); and 999 (95%) stayed at home during their acute infection. Reduced physical capacity (40%), fatigue (39%), cognitive difficulties (30-34%), altered sense of smell (24%), headache (20%), tachycardia (20%), unstable mood (19%), hair loss (17%), and insomnia (17%) were the most often reported symptoms. Those taking daily medication before infection reported increased frequency of both acute and persistent symptoms, except for decreased frequency of persistent altered smell and taste. The presence of persistent symptoms was predicted by taking daily medication before infection and by the total number of acute symptoms. Comorbidities before infection did not predict persistent symptoms. Therefore, the role of medication needs further investigation in both acute SARS-CoV-2 infection and post-COVID-19 condition.", "doi": "10.3390/jcm11216278", "pmid": "36362506", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9657459"}, {"db": "pii", "key": "jcm11216278"}], "notes": [], "created": "2022-11-25T10:45:26.774Z", "modified": "2022-11-25T10:45:39.432Z"}, {"entity": "publication", "iuid": "7d7cf123a0dc4d75bd5aa3ca0a0759dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d7cf123a0dc4d75bd5aa3ca0a0759dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d7cf123a0dc4d75bd5aa3ca0a0759dd"}}, "title": "A Multiparametric and High-Throughput Platform for Host-Virus Binding Screens", "authors": [{"family": "Schlegel", "given": "Jan", "initials": "J"}, {"family": "Porebski", "given": "Bartlomiej", "initials": "B"}, {"family": "Andronico", "given": "Luca", "initials": "L"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Edwards", "given": "Steven", "initials": "S"}, {"family": "Brismar", "given": "Hjalmar", "initials": "H"}, {"family": "Murrell", "given": "Benjamin", "initials": "B"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Fernandez-Capetillo", "given": "Oscar", "initials": "O"}, {"family": "Sezgin", "given": "Erdinc", "initials": "E", "orcid": "0000-0002-4915-388X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30c3688527ac4caf8d07426703ace615.json"}}], "type": "posted-content", "published": "2022-10-11", "journal": {"title": "Medrxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.10.10.511545", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-12-01T13:38:49.854Z", "modified": "2023-01-27T13:01:57.807Z"}, {"entity": "publication", "iuid": "2a24a52cd8c84a8eb843e15301deda1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2a24a52cd8c84a8eb843e15301deda1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2a24a52cd8c84a8eb843e15301deda1d"}}, "title": "Estimated Global Proportions of Individuals With Persistent Fatigue, Cognitive, and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021.", "authors": [{"family": "Global Burden of Disease Long COVID Collaborators", "given": "", "initials": ""}, {"family": "Wulf Hanson", "given": "Sarah", "initials": "S"}, {"family": "Abbafati", "given": "Cristiana", "initials": "C"}, {"family": "Aerts", "given": "Joachim G", "initials": "JG"}, {"family": "Al-Aly", "given": "Ziyad", "initials": "Z"}, {"family": "Ashbaugh", "given": "Charlie", "initials": "C"}, {"family": "Ballouz", "given": "Tala", "initials": "T"}, {"family": "Blyuss", "given": "Oleg", "initials": "O"}, {"family": "Bobkova", "given": "Polina", "initials": "P"}, {"family": "Bonsel", "given": "Gouke", "initials": "G"}, {"family": "Borzakova", "given": "Svetlana", "initials": "S"}, {"family": "Buonsenso", "given": "Danilo", "initials": "D"}, {"family": "Butnaru", "given": "Denis", "initials": "D"}, {"family": "Carter", "given": "Austin", "initials": "A"}, {"family": "Chu", "given": "Helen", "initials": "H"}, {"family": "De Rose", "given": "Cristina", "initials": "C"}, {"family": "Diab", "given": "Mohamed Mustafa", "initials": "MM"}, {"family": "Ekbom", "given": "Emil", "initials": "E"}, {"family": "El Tantawi", "given": "Maha", "initials": "M"}, {"family": "Fomin", "given": "Victor", "initials": "V"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Gamirova", "given": "Aysylu", "initials": "A"}, {"family": "Glybochko", "given": "Petr V", "initials": "PV"}, {"family": "Haagsma", "given": "Juanita A", "initials": "JA"}, {"family": "Haghjooy Javanmard", "given": "Shaghayegh", "initials": "S"}, {"family": "Hamilton", "given": "Erin B", "initials": "EB"}, {"family": "Harris", "given": "Gabrielle", "initials": "G"}, {"family": "Heijenbrok-Kal", "given": "Majanka H", "initials": "MH"}, {"family": "Helbok", "given": "Raimund", "initials": "R"}, {"family": "Hellemons", "given": "Merel E", "initials": "ME"}, {"family": "Hillus", "given": "David", "initials": "D"}, {"family": "Huijts", "given": "Susanne M", "initials": "SM"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Jassat", "given": "Waasila", "initials": "W"}, {"family": "Kurth", "given": "Florian", "initials": "F"}, {"family": "Larsson", "given": "Ing-Marie", "initials": "IM"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Liu", "given": "Chelsea", "initials": "C"}, {"family": "Loflin", "given": "Callan D", "initials": "CD"}, {"family": "Malinovschi", "given": "Andrei", "initials": "A"}, {"family": "Mao", "given": "Wenhui", "initials": "W"}, {"family": "Mazankova", "given": "Lyudmila", "initials": "L"}, {"family": "McCulloch", "given": "Denise", "initials": "D"}, {"family": "Menges", "given": "Dominik", "initials": "D"}, {"family": "Mohammadifard", "given": "Noushin", "initials": "N"}, {"family": "Munblit", "given": "Daniel", "initials": "D"}, {"family": "Nekliudov", "given": "Nikita A", "initials": "NA"}, {"family": "Ogbuoji", "given": "Osondu", "initials": "O"}, {"family": "Osmanov", "given": "Ismail M", "initials": "IM"}, {"family": "Pe\u00f1alvo", "given": "Jos\u00e9 L", "initials": "JL"}, {"family": "Petersen", "given": "Maria Skaalum", "initials": "MS"}, {"family": "Puhan", "given": "Milo A", "initials": "MA"}, {"family": "Rahman", "given": "Mujibur", "initials": "M"}, {"family": "Rass", "given": "Verena", "initials": "V"}, {"family": "Reinig", "given": "Nickolas", "initials": "N"}, {"family": "Ribbers", "given": "Gerard M", "initials": "GM"}, {"family": "Ricchiuto", "given": "Antonia", "initials": "A"}, {"family": "Rubertsson", "given": "Sten", "initials": "S"}, {"family": "Samitova", "given": "Elmira", "initials": "E"}, {"family": "Sarrafzadegan", "given": "Nizal", "initials": "N"}, {"family": "Shikhaleva", "given": "Anastasia", "initials": "A"}, {"family": "Simpson", "given": "Kyle E", "initials": "KE"}, {"family": "Sinatti", "given": "Dario", "initials": "D"}, {"family": "Soriano", "given": "Joan B", "initials": "JB"}, {"family": "Spiridonova", "given": "Ekaterina", "initials": "E"}, {"family": "Steinbeis", "given": "Fridolin", "initials": "F"}, {"family": "Svistunov", "given": "Andrey A", "initials": "AA"}, {"family": "Valentini", "given": "Piero", "initials": "P"}, {"family": "van de Water", "given": "Brittney J", "initials": "BJ"}, {"family": "van den Berg-Emons", "given": "Rita", "initials": "R"}, {"family": "Wallin", "given": "Ewa", "initials": "E"}, {"family": "Witzenrath", "given": "Martin", "initials": "M"}, {"family": "Wu", "given": "Yifan", "initials": "Y"}, {"family": "Xu", "given": "Hanzhang", "initials": "H"}, {"family": "Zoller", "given": "Thomas", "initials": "T"}, {"family": "Adolph", "given": "Christopher", "initials": "C"}, {"family": "Albright", "given": "James", "initials": "J"}, {"family": "Amlag", "given": "Joanne O", "initials": "JO"}, {"family": "Aravkin", "given": "Aleksandr Y", "initials": "AY"}, {"family": "Bang-Jensen", "given": "Bree L", "initials": "BL"}, {"family": "Bisignano", "given": "Catherine", "initials": "C"}, {"family": "Castellano", "given": "Rachel", "initials": "R"}, {"family": "Castro", "given": "Emma", "initials": "E"}, {"family": "Chakrabarti", "given": "Suman", "initials": "S"}, {"family": "Collins", "given": "James K", "initials": "JK"}, {"family": "Dai", "given": "Xiaochen", "initials": "X"}, {"family": "Daoud", "given": "Farah", "initials": "F"}, {"family": "Dapper", "given": "Carolyn", "initials": "C"}, {"family": "Deen", "given": "Amanda", "initials": "A"}, {"family": "Duncan", "given": "Bruce B", "initials": "BB"}, {"family": "Erickson", "given": "Megan", "initials": "M"}, {"family": "Ewald", "given": "Samuel B", "initials": "SB"}, {"family": "Ferrari", "given": "Alize J", "initials": "AJ"}, {"family": "Flaxman", "given": "Abraham D", "initials": "AD"}, {"family": "Fullman", "given": "Nancy", "initials": "N"}, {"family": "Gamkrelidze", "given": "Amiran", "initials": "A"}, {"family": "Giles", "given": "John R", "initials": "JR"}, {"family": "Guo", "given": "Gaorui", "initials": "G"}, {"family": "Hay", "given": "Simon I", "initials": "SI"}, {"family": "He", "given": "Jiawei", "initials": "J"}, {"family": "Helak", "given": "Monika", "initials": "M"}, {"family": "Hulland", "given": "Erin N", "initials": "EN"}, {"family": "Kereselidze", "given": "Maia", "initials": "M"}, {"family": "Krohn", "given": "Kris J", "initials": "KJ"}, {"family": "Lazzar-Atwood", "given": "Alice", "initials": "A"}, {"family": "Lindstrom", "given": "Akiaja", "initials": "A"}, {"family": "Lozano", "given": "Rafael", "initials": "R"}, {"family": "Malta", "given": "Deborah Carvalho", "initials": "DC"}, {"family": "M\u00e5nsson", "given": "Johan", "initials": "J"}, {"family": "Mantilla Herrera", "given": "Ana M", "initials": "AM"}, {"family": "Mokdad", "given": "Ali H", "initials": "AH"}, {"family": "Monasta", "given": "Lorenzo", "initials": "L"}, {"family": "Nomura", "given": "Shuhei", "initials": "S"}, {"family": "Pasovic", "given": "Maja", "initials": "M"}, {"family": "Pigott", "given": "David M", "initials": "DM"}, {"family": "Reiner", "given": "Robert C", "initials": "RC"}, {"family": "Reinke", "given": "Grace", "initials": "G"}, {"family": "Ribeiro", "given": "Antonio Luiz P", "initials": "ALP"}, {"family": "Santomauro", "given": "Damian Francesco", "initials": "DF"}, {"family": "Sholokhov", "given": "Aleksei", "initials": "A"}, {"family": "Spurlock", "given": "Emma Elizabeth", "initials": "EE"}, {"family": "Walcott", "given": "Rebecca", "initials": "R"}, {"family": "Walker", "given": "Ally", "initials": "A"}, {"family": "Wiysonge", "given": "Charles Shey", "initials": "CS"}, {"family": "Zheng", "given": "Peng", "initials": "P"}, {"family": "Bettger", "given": "Janet Prvu", "initials": "JP"}, {"family": "Murray", "given": "Christopher J L", "initials": "CJL"}, {"family": "Vos", "given": "Theo", "initials": "T"}], "type": "journal article", "published": "2022-10-10", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484"}, "abstract": "Some individuals experience persistent symptoms after initial symptomatic SARS-CoV-2 infection (often referred to as Long COVID).\n\nTo estimate the proportion of males and females with COVID-19, younger or older than 20 years of age, who had Long COVID symptoms in 2020 and 2021 and their Long COVID symptom duration.\n\nBayesian meta-regression and pooling of 54 studies and 2 medical record databases with data for 1.2 million individuals (from 22 countries) who had symptomatic SARS-CoV-2 infection. Of the 54 studies, 44 were published and 10 were collaborating cohorts (conducted in Austria, the Faroe Islands, Germany, Iran, Italy, the Netherlands, Russia, Sweden, Switzerland, and the US). The participant data were derived from the 44 published studies (10 501 hospitalized individuals and 42 891 nonhospitalized individuals), the 10 collaborating cohort studies (10 526 and 1906), and the 2 US electronic medical record databases (250 928 and 846 046). Data collection spanned March 2020 to January 2022.\n\nSymptomatic SARS-CoV-2 infection.\n\nProportion of individuals with at least 1 of the 3 self-reported Long COVID symptom clusters (persistent fatigue with bodily pain or mood swings; cognitive problems; or ongoing respiratory problems) 3 months after SARS-CoV-2 infection in 2020 and 2021, estimated separately for hospitalized and nonhospitalized individuals aged 20 years or older by sex and for both sexes of nonhospitalized individuals younger than 20 years of age.\n\nA total of 1.2 million individuals who had symptomatic SARS-CoV-2 infection were included (mean age, 4-66 years; males, 26%-88%). In the modeled estimates, 6.2% (95% uncertainty interval [UI], 2.4%-13.3%) of individuals who had symptomatic SARS-CoV-2 infection experienced at least 1 of the 3 Long COVID symptom clusters in 2020 and 2021, including 3.2% (95% UI, 0.6%-10.0%) for persistent fatigue with bodily pain or mood swings, 3.7% (95% UI, 0.9%-9.6%) for ongoing respiratory problems, and 2.2% (95% UI, 0.3%-7.6%) for cognitive problems after adjusting for health status before COVID-19, comprising an estimated 51.0% (95% UI, 16.9%-92.4%), 60.4% (95% UI, 18.9%-89.1%), and 35.4% (95% UI, 9.4%-75.1%), respectively, of Long COVID cases. The Long COVID symptom clusters were more common in women aged 20 years or older (10.6% [95% UI, 4.3%-22.2%]) 3 months after symptomatic SARS-CoV-2 infection than in men aged 20 years or older (5.4% [95% UI, 2.2%-11.7%]). Both sexes younger than 20 years of age were estimated to be affected in 2.8% (95% UI, 0.9%-7.0%) of symptomatic SARS-CoV-2 infections. The estimated mean Long COVID symptom cluster duration was 9.0 months (95% UI, 7.0-12.0 months) among hospitalized individuals and 4.0 months (95% UI, 3.6-4.6 months) among nonhospitalized individuals. Among individuals with Long COVID symptoms 3 months after symptomatic SARS-CoV-2 infection, an estimated 15.1% (95% UI, 10.3%-21.1%) continued to experience symptoms at 12 months.\n\nThis study presents modeled estimates of the proportion of individuals with at least 1 of 3 self-reported Long COVID symptom clusters (persistent fatigue with bodily pain or mood swings; cognitive problems; or ongoing respiratory problems) 3 months after symptomatic SARS-CoV-2 infection.", "doi": "10.1001/jama.2022.18931", "pmid": "36215063", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "2797443"}], "notes": [], "created": "2022-10-17T14:46:34.295Z", "modified": "2022-10-17T14:47:20.543Z"}, {"entity": "publication", "iuid": "74a421fbdf7a4c958ee21843c31befa5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/74a421fbdf7a4c958ee21843c31befa5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/74a421fbdf7a4c958ee21843c31befa5"}}, "title": "Anti-Spike Mucosal IgA Protection against SARS-CoV-2 Omicron Infection.", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f28f2f6ac9648629c2d2de92fe7bb59.json"}}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Svensson", "given": "Julia", "initials": "J"}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Bacchus", "given": "Philip", "initials": "P", "orcid": "0000-0001-9800-1957", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77e288f7a3b94f6181c7c515273081b0.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "letter", "published": "2022-10-06", "journal": {"title": "N Engl J Med", "issn": "1533-4406", "volume": "387", "issue": "14", "pages": "1333-1336", "issn-l": null}, "abstract": null, "doi": "10.1056/NEJMc2209651", "pmid": "36103621", "labels": {"Category: Omicron VoC": null, "Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9511632"}], "notes": [], "created": "2022-10-13T12:55:59.528Z", "modified": "2023-06-19T14:27:04.997Z"}, {"entity": "publication", "iuid": "92c8bd61f38f45bd9d0efd0d0ebde090", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/92c8bd61f38f45bd9d0efd0d0ebde090.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/92c8bd61f38f45bd9d0efd0d0ebde090"}}, "title": "A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses.", "authors": [{"family": "Lenart", "given": "Klara", "initials": "K"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Ols", "given": "Sebastian", "initials": "S"}, {"family": "Yan", "given": "Xianglei", "initials": "X"}, {"family": "Cagigi", "given": "Alberto", "initials": "A"}, {"family": "Cerveira", "given": "Rodrigo Arcoverde", "initials": "RA"}, {"family": "Winge", "given": "Inga", "initials": "I"}, {"family": "Hanczak", "given": "Jakub", "initials": "J"}, {"family": "Mueller", "given": "Stefan O", "initials": "SO"}, {"family": "Jasny", "given": "Edith", "initials": "E"}, {"family": "Schwendt", "given": "Kim", "initials": "K"}, {"family": "Rauch", "given": "Susanne", "initials": "S"}, {"family": "Petsch", "given": "Benjamin", "initials": "B"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2022-10-06", "journal": {"title": "Mol Ther Methods Clin Dev", "issn": "2329-0501", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "A third vaccine dose is often required to achieve potent, long-lasting immune responses. We investigated the impact of three 8 \u03bcg doses of CVnCoV, CureVac's SARS-CoV-2 vaccine candidate containing sequence-optimized unmodified mRNA encoding spike (S) glycoprotein, administered at 0, 4 and 28 weeks on immune responses in rhesus macaques. Following the third dose S-specific binding and neutralizing antibodies increased 50-fold compared with post-dose 2 levels, with increased responses also evident in the lower airways and against the SARS-CoV-2 B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma) and B.1.617.2 (Delta) variants. Enhanced binding affinity of serum antibodies after the third dose correlated with higher somatic hypermutation in S-specific B cells, corresponding with improved binding properties of monoclonal antibodies expressed from isolated B cells. Administration of low dose mRNA led to fewer cells expressing antigen in vivo at the injection site and in the draining lymph nodes compared with a tenfold higher dose, possibly reducing the engagement of precursor cells with the antigen and resulting in the suboptimal response observed following two-dose vaccination schedules in phase IIb/III clinical trials of CVnCoV. However, when immune memory is established, a third dose efficiently boosts the immunological responses as well as improves antibody affinity and breadth.", "doi": "10.1016/j.omtm.2022.10.001", "pmid": "36217434", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Category: Vaccines": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Research Area: Vaccine": null}, "xrefs": [{"db": "pii", "key": "S2329-0501(22)00143-7"}, {"db": "pmc", "key": "PMC9535876"}], "notes": [], "created": "2022-10-13T15:23:38.735Z", "modified": "2022-10-17T14:57:33.385Z"}, {"entity": "publication", "iuid": "74f12da206e64e47a7de84c81a08e340", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/74f12da206e64e47a7de84c81a08e340.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/74f12da206e64e47a7de84c81a08e340"}}, "title": "A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA Viruses.", "authors": [{"family": "Lindqvist", "given": "Richard", "initials": "R"}, {"family": "Benz", "given": "Caroline", "initials": "C", "orcid": "0000-0002-5166-3598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13332514bfe7460db4a0f134718aa211.json"}}, {"family": "Sereikaite", "given": "Vita", "initials": "V"}, {"family": "Maassen", "given": "Lars", "initials": "L"}, {"family": "Laursen", "given": "Louise", "initials": "L"}, {"family": "Jemth", "given": "Per", "initials": "P", "orcid": "0000-0003-1516-7228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c5fe566cf5f44df9c98bb2b1d7078ba.json"}}, {"family": "Str\u00f8mgaard", "given": "Kristian", "initials": "K"}, {"family": "Ivarsson", "given": "Ylva", "initials": "Y"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK", "orcid": "0000-0001-6553-0940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9024ab251cf44bffbf3229ec909343af.json"}}], "type": "journal article", "published": "2022-10-06", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "10", "pages": "2202", "issn-l": "1999-4915"}, "abstract": "Viruses are dependent on host factors in order to efficiently establish an infection and replicate. Targeting the interactions of such host factors provides an attractive strategy to develop novel antivirals. Syntenin is a protein known to regulate the architecture of cellular membranes by its involvement in protein trafficking and has previously been shown to be important for human papilloma virus (HPV) infection. Here, we show that a highly potent and metabolically stable peptide inhibitor that binds to the PDZ1 domain of syntenin inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by blocking the endosomal entry of the virus. Furthermore, we found that the inhibitor also hampered chikungunya infection and strongly reduced flavivirus infection, which is completely dependent on receptor-mediated endocytosis for their entry. In conclusion, we have identified a novel broad spectrum antiviral inhibitor that efficiently targets a broad range of RNA viruses.", "doi": "10.3390/v14102202", "pmid": "36298757", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC9610207"}, {"db": "pii", "key": "v14102202"}], "notes": [], "created": "2022-10-31T17:26:05.478Z", "modified": "2023-06-19T15:04:01.062Z"}, {"entity": "publication", "iuid": "f47961871afa4d0dbb206f09276a3324", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f47961871afa4d0dbb206f09276a3324.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f47961871afa4d0dbb206f09276a3324"}}, "title": "A regression discontinuity analysis of the social distancing recommendations for older adults in Sweden during COVID-19.", "authors": [{"family": "Bonander", "given": "Carl", "initials": "C", "orcid": "0000-0002-1189-9950", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/386ac82b1a4843828b503ec807c08206.json"}}, {"family": "Stranges", "given": "Debora", "initials": "D", "orcid": "0000-0002-1782-8563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26d57656ec964be89179420faace6222.json"}}, {"family": "Gustavsson", "given": "Johanna", "initials": "J"}, {"family": "Almgren", "given": "Matilda", "initials": "M", "orcid": "0000-0003-1555-8069", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/faba1c6d698d4dffbca95ff4ee838626.json"}}, {"family": "Inghammar", "given": "Malin", "initials": "M"}, {"family": "Moghaddassi", "given": "Mahnaz", "initials": "M", "orcid": "0000-0002-0844-4736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a219bde5ba8a4f3f8655ada08d749885.json"}}, {"family": "Nilsson", "given": "Anton", "initials": "A", "orcid": "0000-0001-5774-7189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/915c1fe25c1d43c3ba55c5793d5e59be.json"}}, {"family": "Capdevila Pujol", "given": "Joan", "initials": "J"}, {"family": "Steves", "given": "Claire", "initials": "C"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Gomez", "given": "Maria F", "initials": "MF"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J", "orcid": "0000-0003-1883-2000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e88fdca336ae41c891f0a46e2481b67f.json"}}, {"family": "COVID Symptom Study Sweden", "given": "", "initials": ""}], "type": "journal article", "published": "2022-10-03", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": "32", "issue": "5", "pages": "799-806"}, "abstract": "This article investigates the impact of a non-mandatory and age-specific social distancing recommendation on isolation behaviours and disease outcomes in Sweden during the first wave of the coronavirus disease 2019 (COVID-19) pandemic (March to July 2020). The policy stated that people aged 70 years or older should avoid crowded places and contact with people outside the household.\n\nWe used a regression discontinuity design-in combination with self-reported isolation data from COVID Symptom Study Sweden (n = 96 053; age range: 39-79 years) and national register data (age range: 39-100+ years) on severe COVID-19 disease (hospitalization or death, n = 21 804) and confirmed cases (n = 48 984)-to estimate the effects of the policy.\n\nOur primary analyses showed a sharp drop in the weekly number of visits to crowded places (-13%) and severe COVID-19 cases (-16%) at the 70-year threshold. These results imply that the age-specific recommendations prevented approximately 1800-2700 severe COVID-19 cases, depending on model specification.\n\nIt seems that the non-mandatory, age-specific recommendations helped control COVID-19 disease during the first wave of the pandemic in Sweden, as opposed to not implementing a social distancing policy aimed at older adults. Our study provides empirical data on how populations may react to non-mandatory, age-specific social distancing policies in the face of a novel virus.", "doi": "10.1093/eurpub/ckac101", "pmid": "35962987", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9384721"}, {"db": "pii", "key": "6665904"}], "notes": [], "created": "2022-08-15T15:25:45.226Z", "modified": "2023-06-19T07:42:36.510Z"}, {"entity": "publication", "iuid": "a7a6bb5249734d7f8974f2cde50ef35a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7a6bb5249734d7f8974f2cde50ef35a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7a6bb5249734d7f8974f2cde50ef35a"}}, "title": "Probing effects of the SARS-CoV-2 E protein on membrane curvature and intracellular calcium.", "authors": [{"family": "Mehregan", "given": "Aujan", "initials": "A"}, {"family": "P\u00e9rez-Conesa", "given": "Sergio", "initials": "S"}, {"family": "Zhuang", "given": "Yuxuan", "initials": "Y"}, {"family": "Elbahnsi", "given": "Ahmad", "initials": "A"}, {"family": "Pasini", "given": "Diletta", "initials": "D"}, {"family": "Lindahl", "given": "Erik", "initials": "E"}, {"family": "Howard", "given": "Rebecca J", "initials": "RJ"}, {"family": "Ulens", "given": "Chris", "initials": "C"}, {"family": "Delemotte", "given": "Lucie", "initials": "L", "orcid": "0000-0002-0828-3899", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c75eddd4cc64423e9899dba6115a26c9.json"}}], "type": "journal article", "published": "2022-10-01", "journal": {"title": "Biochim Biophys Acta Biomembr", "issn": "1879-2642", "issn-l": null, "volume": "1864", "issue": "10", "pages": "183994"}, "abstract": "SARS-CoV-2 contains four structural proteins in its genome. These proteins aid in the assembly and budding of new virions at the ER-Golgi intermediate compartment (ERGIC). Current fundamental research efforts largely focus on one of these proteins - the spike (S) protein. Since successful antiviral therapies are likely to target multiple viral components, there is considerable interest in understanding the biophysical role of its other structural proteins, in particular structural membrane proteins. Here, we have focused our efforts on the characterization of the full-length envelope (E) protein from SARS-CoV-2, combining experimental and computational approaches. Recombinant expression of the full-length E protein from SARS-CoV-2 reveals that this membrane protein is capable of independent multimerization, possibly as a tetrameric or smaller species. Fluorescence microscopy shows that the protein localizes intracellularly, and coarse-grained MD simulations indicate it causes bending of the surrounding lipid bilayer, corroborating a potential role for the E protein in viral budding. Although we did not find robust electrophysiological evidence of ion-channel activity, cells transfected with the E protein exhibited reduced intracellular Ca2+, which may further promote viral replication. However, our atomistic MD simulations revealed that previous NMR structures are relatively unstable, and result in models incapable of ion conduction. Our study highlights the importance of using high-resolution structural data obtained from a full-length protein to gain detailed molecular insights, and eventually permitting virtual drug screening.", "doi": "10.1016/j.bbamem.2022.183994", "pmid": "35724739", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: VR": null, "Category: Imaging": null, "Funder: KAW/SciLifeLab": null, "Research Area: Drug discovery and repurposing of drugs": null}, "xrefs": [{"db": "pmc", "key": "PMC9212275"}, {"db": "pii", "key": "S0005-2736(22)00132-8"}], "notes": [], "created": "2022-08-15T13:04:26.500Z", "modified": "2023-10-04T08:21:52.816Z"}, {"entity": "publication", "iuid": "23211eab6ea84a5cb42fac597ead9172", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23211eab6ea84a5cb42fac597ead9172.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23211eab6ea84a5cb42fac597ead9172"}}, "title": "Association of COVID-19 Infection With Wearing Glasses in a High-Prevalence Area in Denmark and Sweden.", "authors": [{"family": "Gregersen", "given": "Rasmus", "initials": "R"}, {"family": "Jacobsen", "given": "Rikke Kart", "initials": "RK"}, {"family": "Laursen", "given": "Jannie", "initials": "J"}, {"family": "Mobech", "given": "Regine", "initials": "R"}, {"family": "Ostrowski", "given": "Sisse Rye", "initials": "SR"}, {"family": "Iversen", "given": "Kasper", "initials": "K"}, {"family": "Petersen", "given": "Janne", "initials": "J"}], "type": "journal article", "published": "2022-10-01", "journal": {"title": "JAMA Ophthalmol", "issn": "2168-6173", "volume": "140", "issue": "10", "pages": "957-964", "issn-l": null}, "abstract": "Observational studies have indicated that glasses might protect against contracting COVID-19 through reduced airborne and contact transmission.\n\nTo investigate the association between wearing one's own glasses with contracting COVID-19 when adjusting for relevant confounders.\n\nThis cohort study was conducted during the first wave of the COVID-19 pandemic (June to August 2020) in Denmark and Sweden, where personal protective equipment was not recommended for the general population at the time. Employees at Falck, an international rescue corps with different job functions (ambulance, health care, office, and field staff, firefighters, and roadside assistance) participated in the study.\n\nThe main exposure was wearing glasses (also including contact lenses and reading glasses), which was assessed in a questionnaire. Persons wearing glasses were compared with those who did not wear glasses (ie, nonusers). To adjust for potential confounders, information on age, sex, job function, and number of workday contacts were included.\n\nThe outcome was COVID-19 infection before (positive polymerase chain reaction test) or during the study period (biweekly voluntary tests with a rapid test). The investigated hypothesis was formulated after collecting the data.\n\nA total of 1279 employees in Denmark and 841 in Sweden were included (839 [39.6%] female and 1281 [60.4%] male; 20.5% were aged <40 years; 57.0%, 40-60 years, and 22.5%, >60 years). Of these, 829 individuals (64.8%) in Denmark and 619 (73.6%) in Sweden wore glasses. Wearing glasses was inversely associated with COVID-19 infection in the Swedish cohort (odds ratio [OR], 0.61 [95% CI, 0.37-0.99]; P = .047; seroprevalence, 9.3%) but not in the Danish cohort (OR, 1.14 [95% CI, 0.53-2.45]; P = .73; seroprevalence, 2.4%). Adjusting for age, sex, job function, and number of workday contacts in Sweden, wearing glasses no longer was associated with COVID-19 infection (OR, 0.64 [95% CI, 0.37-1.11]; P = .11). When stratifying by job function, a large difference was observed among office staff (OR, 0.20 [95% CI, 0.06-0.70]; P = .01) but not ambulance staff (OR, 0.83 [95% CI, 0.41-1.67]; P = .60) nor health care staff (OR, 0.89 [95% CI, 0.35-2.30]; P = .81).\n\nWhile wearing one's glasses was inversely associated with COVID-19 in Sweden in an unadjusted analysis, an association no longer was identified when adjusting for confounders. These results provide inconclusive findings regarding whether wearing one's own glasses is associated with a decreased risk of COVID-19 infections.", "doi": "10.1001/jamaophthalmol.2022.3234", "pmid": "36006635", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9412836"}, {"db": "pii", "key": "2795676"}], "notes": [], "created": "2022-08-26T04:42:09.969Z", "modified": "2023-01-13T13:33:16.749Z"}, {"entity": "publication", "iuid": "ae405af650f2480a8b7b65aee874a1ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ae405af650f2480a8b7b65aee874a1ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ae405af650f2480a8b7b65aee874a1ae"}}, "title": "Years of life lost during the Covid-19 pandemic in Sweden considering variation in life expectancy by level of geriatric care.", "authors": [{"family": "Ebeling", "given": "Marcus", "initials": "M", "orcid": "0000-0002-6531-8525", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68c1d52cda8f44b08a880cff988da4fe.json"}}, {"family": "Acosta", "given": "Enrique", "initials": "E", "orcid": "0000-0001-6250-4018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58eb2562f719445ca58bbe4767ff3c05.json"}}, {"family": "Caswell", "given": "Hal", "initials": "H", "orcid": "0000-0003-4394-6894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cc33d38bae1411d99d1cb998c10b407.json"}}, {"family": "Meyer", "given": "Anna C", "initials": "AC", "orcid": "0000-0003-2749-7179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/85b259806e24408cba7ef935931c0cc9.json"}}, {"family": "Modig", "given": "Karin", "initials": "K", "orcid": "0000-0002-5151-4867", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b60a410c326c43df8256b3ffd7cd38d4.json"}}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "Eur J Epidemiol", "issn": "1573-7284", "volume": "37", "issue": "10", "pages": "1025-1034", "issn-l": "0393-2990"}, "abstract": "The Covid-19 pandemic has not affected the population evenly. This must be acknowledged when it comes to understanding the Covid-19 death toll and answering the question of how many life years have been lost. We use level of geriatric care to account for variation in remaining life expectancy among individuals that died during 2020. Based on a linkage of administrative registers, we estimate remaining life expectancy stratified by age, sex, and care status using an incidence-based multistate model and analyze the number of years of life lost (YLL) during 2020 in Sweden. Our results show that remaining life expectancy between individuals with and without care differs substantially. More than half of all Covid-19 deaths had a remaining life expectancy lower than 4 years. Yet, in a 1-year perspective, Covid-19 did not seem to replace other causes of death. Not considering the differences in remaining life expectancy in the affected populations overestimated YLL by 40% for women and 30% for men, or around 2 years per death. While the unadjusted YLL from Covid-19 amounted to an average of 7.5 years for women and 8.6 years for men, the corresponding YLL adjusted for care status were 5.4 and 6.6, respectively. The total number of YLL to Covid-19 in 2020 is comparable to YLL from ischemic heart disease in 2019 and 2020. Our results urge the use of subgroup specific mortality when counting the burden of Covid-19. YLL are considerably reduced when the varying susceptibility for death is considered, but even if most lifespans were cut in the last years of life, the YLL are still substantial.", "doi": "10.1007/s10654-022-00915-z", "pmid": "36127511", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9488891"}, {"db": "pii", "key": "10.1007/s10654-022-00915-z"}], "notes": [], "created": "2023-01-13T13:53:50.160Z", "modified": "2023-01-13T13:53:50.311Z"}, {"entity": "publication", "iuid": "43e0662d439441f38ff4e351cb71c5e0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/43e0662d439441f38ff4e351cb71c5e0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/43e0662d439441f38ff4e351cb71c5e0"}}, "title": "The Dual Pandemics of COVID-19 and Obesity: Bidirectional Impact.", "authors": [{"family": "Kapoor", "given": "Nitin", "initials": "N"}, {"family": "Kalra", "given": "Sanjay", "initials": "S"}, {"family": "Al Mahmeed", "given": "Wael", "initials": "W"}, {"family": "Al-Rasadi", "given": "Khalid", "initials": "K"}, {"family": "Al-Alawi", "given": "Kamila", "initials": "K"}, {"family": "Banach", "given": "Maciej", "initials": "M"}, {"family": "Banerjee", "given": "Yajnavalka", "initials": "Y"}, {"family": "Ceriello", "given": "Antonio", "initials": "A"}, {"family": "Cesur", "given": "Mustafa", "initials": "M"}, {"family": "Cosentino", "given": "Francesco", "initials": "F"}, {"family": "Firenze", "given": "Alberto", "initials": "A"}, {"family": "Galia", "given": "Massimo", "initials": "M"}, {"family": "Goh", "given": "Su-Yen", "initials": "S"}, {"family": "Janez", "given": "Andrej", "initials": "A"}, {"family": "Kempler", "given": "Peter", "initials": "P"}, {"family": "Lessan", "given": "Nader", "initials": "N"}, {"family": "Lotufo", "given": "Paulo", "initials": "P"}, {"family": "Papanas", "given": "Nikolaos", "initials": "N"}, {"family": "Rizvi", "given": "Ali A", "initials": "AA"}, {"family": "Sahebkar", "given": "Amirhossein", "initials": "A"}, {"family": "Santos", "given": "Raul D", "initials": "RD"}, {"family": "Stoian", "given": "Anca Pantea", "initials": "AP"}, {"family": "Toth", "given": "Peter P", "initials": "PP"}, {"family": "Viswanathan", "given": "Vijay", "initials": "V"}, {"family": "Rizzo", "given": "Manfredi", "initials": "M"}, {"family": "CArdiometabolic Panel of International experts on Syndemic COvid-19 (CAPISCO)", "given": "", "initials": ""}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "Diabetes Ther", "issn": "1869-6953", "issn-l": null, "volume": "13", "issue": "10", "pages": "1723-1736"}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the COVID-19 pandemic, has been shown to disrupt many organ systems in the human body. Though several medical disorders have been affected by this infection, a few illnesses in addition may also play a role in determining the outcome of COVID-19. Obesity is one such disease which is not only affected by the occurrence of COVID-19 but can also result in a worse clinical outcome of COVID-19 infection. This manuscript summarizes the most recent evidence supporting the bidirectional impact of COVID-19 and obesity. It highlights how the presence of obesity can be detrimental to the outcome of COVID-19 in a given patient because of the mechanical limitations in lung compliance and also by the activation of several thrombo-inflammatory pathways. The sociodemographic changes brought about by the pandemic in turn have facilitated the already increasing prevalence of obesity. This manuscript highlights the importance of recognizing these pathways which may further help in policy changes that facilitate appropriate measures to prevent the further worsening of these two pandemics.", "doi": "10.1007/s13300-022-01311-2", "pmid": "36030317", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s13300-022-01311-2"}, {"db": "pmc", "key": "PMC9419639"}], "notes": [], "created": "2022-10-07T12:40:52.100Z", "modified": "2022-10-07T12:41:32.075Z"}, {"entity": "publication", "iuid": "0a56301865724fb4907f0e0c27be5a82", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a56301865724fb4907f0e0c27be5a82.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a56301865724fb4907f0e0c27be5a82"}}, "title": "Severity of COVID19 infection among patients with multiple sclerosis treated with interferon-\u03b2.", "authors": [{"family": "Simpson-Yap", "given": "Steve", "initials": "S", "orcid": "0000-0001-6521-3056", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/845cbea3a2f64b9f880a43d6cc8cdb09.json"}}, {"family": "Pirmani", "given": "Ashkan", "initials": "A"}, {"family": "De Brouwer", "given": "Edward", "initials": "E"}, {"family": "Peeters", "given": "Liesbet M", "initials": "LM"}, {"family": "Geys", "given": "Lotte", "initials": "L"}, {"family": "Parciak", "given": "Tina", "initials": "T"}, {"family": "Helme", "given": "Anne", "initials": "A"}, {"family": "Hillert", "given": "Jan", "initials": "J"}, {"family": "Moreau", "given": "Yves", "initials": "Y"}, {"family": "Edan", "given": "Gilles", "initials": "G"}, {"family": "Spelman", "given": "Tim", "initials": "T"}, {"family": "Sharmin", "given": "Sifat", "initials": "S"}, {"family": "McBurney", "given": "Robert", "initials": "R"}, {"family": "Schmidt", "given": "Hollie", "initials": "H"}, {"family": "Bergmann", "given": "Arnfin", "initials": "A"}, {"family": "Braune", "given": "Stefan", "initials": "S"}, {"family": "Stahmann", "given": "Alexander", "initials": "A"}, {"family": "Middleton", "given": "Rodden", "initials": "R"}, {"family": "Salter", "given": "Amber", "initials": "A"}, {"family": "Bebo", "given": "Bruce", "initials": "B"}, {"family": "van der Walt", "given": "Anneke", "initials": "A"}, {"family": "Butzkueven", "given": "Helmut", "initials": "H"}, {"family": "Ozakbas", "given": "Serkan", "initials": "S"}, {"family": "Karabudak", "given": "Rana", "initials": "R"}, {"family": "Boz", "given": "Cavit", "initials": "C"}, {"family": "Alroughani", "given": "Raed", "initials": "R"}, {"family": "Rojas", "given": "Juan I", "initials": "JI"}, {"family": "van der Mei", "given": "Ingrid", "initials": "I"}, {"family": "Sciascia do Olival", "given": "Guilherme", "initials": "G"}, {"family": "Magyari", "given": "Melinda", "initials": "M"}, {"family": "Alonso", "given": "Ricardo", "initials": "R"}, {"family": "Nicholas", "given": "Richard", "initials": "R"}, {"family": "Chertcoff", "given": "Anibal", "initials": "A"}, {"family": "Zabalza", "given": "Ana", "initials": "A"}, {"family": "Arrambide", "given": "Georgina", "initials": "G"}, {"family": "Nag", "given": "Nupur", "initials": "N"}, {"family": "Descamps", "given": "Annabel", "initials": "A"}, {"family": "Costers", "given": "Lars", "initials": "L"}, {"family": "Dobson", "given": "Ruth", "initials": "R"}, {"family": "Miller", "given": "Aleisha", "initials": "A"}, {"family": "Rodrigues", "given": "Paulo", "initials": "P"}, {"family": "Pr\u010dkovska", "given": "Vesna", "initials": "V"}, {"family": "Comi", "given": "Giancarlo", "initials": "G"}, {"family": "Kalincik", "given": "Tomas", "initials": "T"}], "type": "letter", "published": "2022-10-00", "journal": {"title": "Mult Scler Relat Disord", "issn": "2211-0356", "volume": "66", "pages": "104072", "issn-l": null}, "abstract": "Interferon-\u03b2, a disease-modifying therapy (DMT) for MS, may be associated with less severe COVID-19 in people with MS.\n\nAmong 5,568 patients (83.4% confirmed COVID-19), interferon-treated patients had lower risk of severe COVID-19 compared to untreated, but not to glatiramer-acetate, dimethyl-fumarate, or pooled other DMTs.\n\nIn comparison to other DMTs, we did not find evidence of protective effects of interferon-\u03b2 on the severity of COVID-19, though compared to the untreated, the course of COVID19 was milder among those on interferon-\u03b2. This study does not support the use of interferon-\u03b2 as a treatment to reduce COVID-19 severity in MS.", "doi": "10.1016/j.msard.2022.104072", "pmid": "35917745", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9310378"}, {"db": "pii", "key": "S2211-0348(22)00580-6"}], "notes": [], "created": "2022-08-11T12:02:34.852Z", "modified": "2023-06-19T14:41:22.654Z"}, {"entity": "publication", "iuid": "125837694ec841ec8b0ab596b5e550a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/125837694ec841ec8b0ab596b5e550a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/125837694ec841ec8b0ab596b5e550a6"}}, "title": "Severe COVID-19 in people 55 and older during the first year of the pandemic in Sweden.", "authors": [{"family": "Rosengren", "given": "Annika", "initials": "A"}, {"family": "Lundberg", "given": "Christina E", "initials": "CE"}, {"family": "S\u00f6derberg", "given": "Mia", "initials": "M"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Edqvist", "given": "Jon", "initials": "J"}, {"family": "Lindgren", "given": "Martin", "initials": "M"}, {"family": "\u00c5berg", "given": "Maria", "initials": "M"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Robertson", "given": "Josefina", "initials": "J"}, {"family": "Cronie", "given": "Ottmar", "initials": "O"}, {"family": "Sattar", "given": "Naveed", "initials": "N"}, {"family": "Lagergren", "given": "Jesper", "initials": "J"}, {"family": "Brand\u00e9n", "given": "Maria", "initials": "M"}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}, {"family": "Adiels", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": "292", "issue": "4", "pages": "641-653"}, "abstract": "Exposure to many contacts is the main risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, while risk of serious disease and death is chiefly determined by old age and comorbidities. Relative and population-attributable fractions (PAFs) of multiple medical and social exposures for COVID-19 outcomes have not been evaluated among older adults.\r\n\r\nWe describe the effect of multiple exposures on the odds of testing positive for the virus and of severe disease (hospital care or death) and PAFs in Swedish citizens aged 55 years and above.\r\n\r\nWe used national registers to follow all citizens aged 55 years and above with respect to (1) testing positive, (2) hospitalization, and (3) death between 31 January 2020 and 1 February 2021.\r\n\r\nOf 3,410,241 persons, 156,017 (4.6%, mean age 68.3 years) tested positive for SARS-CoV-2, while 35,999 (1.1%, mean age 76.7 years) were hospitalized or died (12,384 deaths, 0.4%, mean age 84.0 years). Among the total cohort, the proportion living without home care or long-term care was 98.8% among persons aged 55-64 and 22.1% of those aged 95 and above. After multiple adjustment, home care and long-term care were associated with odds ratios of 7.9 (95% confidence interval [CI] 6.8-9.1) and 22.5 (95% CI 19.6-25.7) for mortality, with PAFs of 21.9% (95% CI 20.9-22.9) and 33.3% (95% CI 32.4-34.3), respectively.\r\n\r\nAmong Swedish residents aged 55 years and above, those with home care or long-term care had markedly increased risk for COVID-19 death during the first year of the pandemic, with over 50% of deaths attributable to these factors.", "doi": "10.1111/joim.13522", "pmid": "35612518", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC9348046"}], "notes": [], "created": "2022-06-21T17:51:17.657Z", "modified": "2022-10-13T14:39:34.245Z"}, {"entity": "publication", "iuid": "c247a0d7b8c6418b9ab769b6a49da500", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c247a0d7b8c6418b9ab769b6a49da500.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c247a0d7b8c6418b9ab769b6a49da500"}}, "title": "SARS-CoV-2 spike protein aggregation is triggered by bacterial lipopolysaccharide.", "authors": [{"family": "Petrlova", "given": "Jitka", "initials": "J", "orcid": "0000-0002-7554-3945", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a58aee20cb4847d99c9b307c76fdda74.json"}}, {"family": "Samsudin", "given": "Firdaus", "initials": "F"}, {"family": "Bond", "given": "Peter J", "initials": "PJ"}, {"family": "Schmidtchen", "given": "Artur", "initials": "A", "orcid": "0000-0001-9209-3141", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/426e00c7c8314ea195f2670af469e19a.json"}}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "FEBS Lett", "issn": "1873-3468", "volume": "596", "issue": "19", "pages": "2566-2575", "issn-l": null}, "abstract": "SARS-CoV-2 spike (S) protein is crucial for virus invasion in COVID-19. Here, we showed that lipopolysaccharide (LPS) can trigger S protein aggregation at high doses of LPS and S protein. We demonstrated the formation of S protein aggregates by microscopy analyses, aggregation and gel shift assays. LPS at high levels boosts the formation of S protein aggregates as detected by amytracker and thioflavin T dyes that specifically bind to aggregating proteins. We validated the role of LPS by blocking the formation of aggregates by the endotoxin-scavenging thrombin-derived peptide TCP-25. Aggregation-prone sequences in S protein are predicted to be nearby LPS binding sites, while molecular simulations showed stable formation of S protein-LPS higher-order oligomers. Collectively, our results provide evidence of LPS-induced S protein aggregation.", "doi": "10.1002/1873-3468.14490", "pmid": "36050806", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9538650"}], "notes": [], "created": "2022-10-13T13:15:42.794Z", "modified": "2022-10-13T13:17:51.776Z"}, {"entity": "publication", "iuid": "9a98809b3327409e8e37fc73fd45ad63", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9a98809b3327409e8e37fc73fd45ad63.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9a98809b3327409e8e37fc73fd45ad63"}}, "title": "No effect of remdesivir or betamethasone on upper respiratory tract SARS-CoV-2 RNA kinetics in hospitalised COVID-19 patients: a retrospective observational study.", "authors": [{"family": "Sourander", "given": "Birger", "initials": "B"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "L"}, {"family": "Brink", "given": "Magnus", "initials": "M"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Sundell", "given": "Nicklas", "initials": "N"}, {"family": "Marklund", "given": "Emelie", "initials": "E"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Robertson", "given": "Josefina", "initials": "J"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": "54", "issue": "10", "pages": "703-712"}, "abstract": "The viral kinetics of SARS-CoV-2 has been considered clinically important. While remdesivir and corticosteroids are recommended for COVID-19 patients requiring oxygen support, there is a limited number of published reports on viral kinetics in hospitalised patients with COVID-19 treated with remdesivir or corticosteroids.\r\n\r\nWe conducted a retrospective study by collecting longitudinal samples from the nasopharynx/throat of 123 hospitalised patients (median age 55 years, 74% male) with COVID-19, to evaluate the effects of remdesivir and corticosteroid treatment on viral RNA levels. The subjects were divided into four groups: those receiving remdesivir (n = 25), betamethasone (n = 41), both (n = 15), or neither (n = 42). Time to viral RNA clearance was analysed using Kaplan-Meier plots, categorical data were analysed using Fisher's exact test, and Kruskal-Wallis for continuous data. Viral RNA decline rate was analysed using a mixed effect model.\r\n\r\nWe found no significant difference in SARS-CoV-2 RNA decline rate or time to SARS-CoV-2 RNA clearance between the groups. Moreover, clinical status at baseline was not correlated with time to viral clearance.\r\n\r\nSince SARS-CoV-2 RNA kinetics was not affected by treatment, repeated sampling from the upper respiratory tract cannot be used to evaluate treatment response.", "doi": "10.1080/23744235.2022.2081716", "pmid": "35708280", "labels": {"Category: Drug Discovery": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2022-06-20T18:10:19.043Z", "modified": "2022-10-13T14:40:38.264Z"}, {"entity": "publication", "iuid": "a59e71c204fc4f40a3f4d5c31324c22b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a59e71c204fc4f40a3f4d5c31324c22b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a59e71c204fc4f40a3f4d5c31324c22b"}}, "title": "Infection Rate of SARS-CoV-2 in Asymptomatic Healthcare Workers, Sweden, June 2022.", "authors": [{"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Norin", "given": "Nina Greilert", "initials": "NG"}, {"family": "Bacchus", "given": "Philip", "initials": "P"}, {"family": "Groenheit", "given": "Ramona", "initials": "R"}, {"family": "Br\u00e5ve", "given": "Andreas", "initials": "A"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}], "type": "letter", "published": "2022-10-00", "journal": {"title": "Emerg Infect Dis", "issn": "1080-6059", "volume": "28", "issue": "10", "pages": "2119-2121", "issn-l": null}, "abstract": "Given the recent surge in SARS-CoV-2 Omicron infections, we performed a quantitative PCR screening survey during June 28-29, 2022, in Stockholm, Sweden, to investigate SARS-CoV-2 point prevalence in a group with high exposure risk. Results showed SARS-CoV-2 infection in 2.3% of healthcare workers who were asymptomatic at time of sampling.", "doi": "10.3201/eid2810.221093", "pmid": "35997692", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9514358"}], "notes": [], "created": "2022-08-26T04:45:09.756Z", "modified": "2023-06-19T14:27:18.248Z"}, {"entity": "publication", "iuid": "01c40c37457844aabd726103ec1267ba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01c40c37457844aabd726103ec1267ba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01c40c37457844aabd726103ec1267ba"}}, "title": "Induced abortion and access to contraception in Sweden during the COVID-19 pandemic.", "authors": [{"family": "Niemeyer Hultstrand", "given": "Jenny", "initials": "J", "orcid": "0000-0002-2304-2006", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/abc93f26a58947fea94714306129d45d.json"}}, {"family": "T\u00f6rnroos", "given": "Elin", "initials": "E"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}, {"family": "Larsson", "given": "Margareta I", "initials": "MI"}, {"family": "Makenzius", "given": "Marlene", "initials": "M"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Tyd\u00e9n", "given": "Tanja", "initials": "T"}, {"family": "Ekstrand Ragnar", "given": "Maria", "initials": "M"}], "type": "letter", "published": "2022-10-00", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-2009", "volume": "48", "issue": "4", "pages": "311-312", "issn-l": "2515-1991"}, "abstract": null, "doi": "10.1136/bmjsrh-2022-201464", "pmid": "35332034", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjsrh-2022-201464"}], "notes": [], "created": "2022-04-04T06:58:49.184Z", "modified": "2023-01-13T13:34:18.406Z"}, {"entity": "publication", "iuid": "ac4ad25a4acc4c9ea992394d22cb4c67", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac4ad25a4acc4c9ea992394d22cb4c67.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac4ad25a4acc4c9ea992394d22cb4c67"}}, "title": "Desire to work from home: Results of an Irish study.", "authors": [{"family": "Stefaniec", "given": "Agnieszka", "initials": "A"}, {"family": "Brazil", "given": "William", "initials": "W"}, {"family": "Whitney", "given": "Warren", "initials": "W"}, {"family": "Caulfield", "given": "Brian", "initials": "B"}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "J Transp Geogr", "issn": "0966-6923", "issn-l": null, "volume": "104", "issue": null, "pages": "103416"}, "abstract": "Large levels of working from home (WfH) were induced by social distancing and viral control measures undertaken to mitigate the Covid-19 pandemic. Representing an unpredicted change in the way large amounts of people undertake their day to day work, it is expected that the legacy of this event, in terms of significant alterations to work and commuting patterns will have wide-ranging and long-lasting results. However, how persistent the current trends will be, remains an open question. Therefore, there is a need for a well-represented study of employees' preferences for the post-pandemic future and focus on white-collar workers and their well-established attitudes considering their flexibility in terms of workplace arrangements. This paper presents the results of a survey undertaken in Ireland in the summer of 2021 gauging the desire of office workers to WfH, the format that most appeals to them, the consideration of home relocation based on the ability to WfH, and the factors that may explain such preferences. Results indicate high levels of desire to WfH, either full time or partially, with increased desire to WfH positively correlated to pre-pandemic commute length, and to a perceived increase in work productivity and quality of non-work life as a result of time spent WfH. Additionally, a number of workers state that they may consider home relocation based upon the ability to WfH. These results should be interpreted as the desire to WfH or total addressable market that exists, rather than the likely levels of WfH that will be observed post-Covid.", "doi": "10.1016/j.jtrangeo.2022.103416", "pmid": "35992220", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0966-6923(22)00139-9"}, {"db": "pmc", "key": "PMC9379795"}], "notes": [], "created": "2022-09-12T18:52:28.755Z", "modified": "2022-11-09T08:36:41.448Z"}, {"entity": "publication", "iuid": "3239af756d1f41f3bbfd495afcec99d3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3239af756d1f41f3bbfd495afcec99d3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3239af756d1f41f3bbfd495afcec99d3"}}, "title": "Comprehensive analysis of pathways in Coronavirus 2019 (COVID-19) using an unsupervised machine learning method.", "authors": [{"family": "Taheri", "given": "Golnaz", "initials": "G"}, {"family": "Habibi", "given": "Mahnaz", "initials": "M"}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "Appl Soft Comput", "issn": "1568-4946", "volume": "128", "pages": "109510", "issn-l": null}, "abstract": "The World Health Organization (WHO) introduced \"Coronavirus disease 19\" or \"COVID-19\" as a novel coronavirus in March 2020. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires the fast discovery of effective treatments to fight this worldwide crisis. Artificial intelligence and bioinformatics analysis pipelines can assist with finding biomarkers, explanations, and cures. Artificial intelligence and machine learning methods provide powerful infrastructures for interpreting and understanding the available data. On the other hand, pathway enrichment analysis, as a dominant tool, could help researchers discover potential key targets present in biological pathways of host cells that are targeted by SARS-CoV-2. In this work, we propose a two-stage machine learning approach for pathway analysis. During the first stage, four informative gene sets that can represent important COVID-19 related pathways are selected. These \"representative genes\" are associated with the COVID-19 pathology. Then, two distinctive networks were constructed for COVID-19 related signaling and disease pathways. In the second stage, the pathways of each network are ranked with respect to some unsupervised scorning method based on our defined informative features. Finally, we present a comprehensive analysis of the top important pathways in both networks. Materials and implementations are available at: https://github.com/MahnazHabibi/Pathway.", "doi": "10.1016/j.asoc.2022.109510", "pmid": "35992221", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1568-4946(22)00596-8"}, {"db": "pmc", "key": "PMC9384336"}], "notes": [], "created": "2022-09-12T18:52:34.765Z", "modified": "2022-09-12T18:52:44.843Z"}, {"entity": "publication", "iuid": "2d1ee9ca5d6e413c8099707e881b182c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d1ee9ca5d6e413c8099707e881b182c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d1ee9ca5d6e413c8099707e881b182c"}}, "title": "CODE-EHR best-practice framework for the use of structured electronic health-care records in clinical research.", "authors": [{"family": "Kotecha", "given": "Dipak", "initials": "D"}, {"family": "Asselbergs", "given": "Folkert W", "initials": "FW"}, {"family": "Achenbach", "given": "Stephan", "initials": "S"}, {"family": "Anker", "given": "Stefan D", "initials": "SD"}, {"family": "Atar", "given": "Dan", "initials": "D"}, {"family": "Baigent", "given": "Colin", "initials": "C"}, {"family": "Banerjee", "given": "Amitava", "initials": "A"}, {"family": "Beger", "given": "Birgit", "initials": "B"}, {"family": "Brobert", "given": "Gunnar", "initials": "G"}, {"family": "Casadei", "given": "Barbara", "initials": "B"}, {"family": "Ceccarelli", "given": "Cinzia", "initials": "C"}, {"family": "Cowie", "given": "Martin R", "initials": "MR"}, {"family": "Crea", "given": "Filippo", "initials": "F"}, {"family": "Cronin", "given": "Maureen", "initials": "M"}, {"family": "Denaxas", "given": "Spiros", "initials": "S"}, {"family": "Derix", "given": "Andrea", "initials": "A"}, {"family": "Fitzsimons", "given": "Donna", "initials": "D"}, {"family": "Fredriksson", "given": "Martin", "initials": "M"}, {"family": "Gale", "given": "Chris P", "initials": "CP"}, {"family": "Gkoutos", "given": "Georgios V", "initials": "GV"}, {"family": "Goettsch", "given": "Wim", "initials": "W"}, {"family": "Hemingway", "given": "Harry", "initials": "H"}, {"family": "Ingvar", "given": "Martin", "initials": "M"}, {"family": "Jonas", "given": "Adrian", "initials": "A"}, {"family": "Kazmierski", "given": "Robert", "initials": "R"}, {"family": "L\u00f8gstrup", "given": "Susanne", "initials": "S"}, {"family": "Lumbers", "given": "R Thomas", "initials": "RT"}, {"family": "L\u00fcscher", "given": "Thomas F", "initials": "TF"}, {"family": "McGreavy", "given": "Paul", "initials": "P"}, {"family": "Pi\u00f1a", "given": "Ileana L", "initials": "IL"}, {"family": "Roessig", "given": "Lothar", "initials": "L"}, {"family": "Steinbeisser", "given": "Carl", "initials": "C"}, {"family": "Sundgren", "given": "Mats", "initials": "M"}, {"family": "Tyl", "given": "Beno\u00eet", "initials": "B"}, {"family": "Thiel", "given": "Ghislaine van", "initials": "GV"}, {"family": "Bochove", "given": "Kees van", "initials": "KV"}, {"family": "Vardas", "given": "Panos E", "initials": "PE"}, {"family": "Villanueva", "given": "Tiago", "initials": "T"}, {"family": "Vrana", "given": "Marilena", "initials": "M"}, {"family": "Weber", "given": "Wim", "initials": "W"}, {"family": "Weidinger", "given": "Franz", "initials": "F"}, {"family": "Windecker", "given": "Stephan", "initials": "S"}, {"family": "Wood", "given": "Angela", "initials": "A"}, {"family": "Grobbee", "given": "Diederick E", "initials": "DE"}, {"family": "Innovative Medicines Initiative BigData@Heart Consortium, European Society of Cardiology, and CODE-EHR International Consensus Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "The Lancet Digital Health", "issn": "2589-7500", "volume": "4", "issue": "10", "pages": "e757-e764", "issn-l": null}, "abstract": "Big data is important to new developments in global clinical science that aim to improve the lives of patients. Technological advances have led to the regular use of structured electronic health-care records with the potential to address key deficits in clinical evidence that could improve patient care. The COVID-19 pandemic has shown this potential in big data and related analytics but has also revealed important limitations. Data verification, data validation, data privacy, and a mandate from the public to conduct research are important challenges to effective use of routine health-care data. The European Society of Cardiology and the BigData@Heart consortium have brought together a range of international stakeholders, including representation from patients, clinicians, scientists, regulators, journal editors, and industry members. In this Review, we propose the CODE-EHR minimum standards framework to be used by researchers and clinicians to improve the design of studies and enhance transparency of study methods. The CODE-EHR framework aims to develop robust and effective utilisation of health-care data for research purposes.", "doi": "10.1016/S2589-7500(22)00151-0", "pmid": "36050271", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2589-7500(22)00151-0"}], "notes": [], "created": "2022-10-13T13:06:28.143Z", "modified": "2022-10-13T13:06:28.156Z"}, {"entity": "publication", "iuid": "0f906486a40f462c9c666a0a0e72b164", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0f906486a40f462c9c666a0a0e72b164.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0f906486a40f462c9c666a0a0e72b164"}}, "title": "Favorable Adaptation during SARS-CoV-2-Pandemic as Told by Student-Athletes-A Longitudinal and Behavioral Study.", "authors": [{"family": "Johnson", "given": "Urban", "initials": "U"}, {"family": "Hertting", "given": "Krister", "initials": "K", "orcid": "0000-0003-2347-4391", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98fbb192394e443c8f3feeee090189fe.json"}}, {"family": "Ivarsson", "given": "Andreas", "initials": "A"}, {"family": "Lindgren", "given": "Eva-Carin", "initials": "E"}], "type": "journal article", "published": "2022-09-30", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "19", "issue": "19", "pages": null}, "abstract": "(1) Background: The aim was to explore the impact of adaptive responses (resilience factors) on student-athletes' behaviors during a stressful period of life during the SARS-CoV-2-pandemic of 2020 and 2021. (2) Methods: A constructivist-based grounded theory (CGT) was used guided by a biopsychosocial approach. Based on purposeful sampling, 22 male and female student-athletes were divided into four focus group interviews (FGI) seven months after the outbreak of the SARS-CoV-2-pandemic (October 2020) and 18 of these were followed up by FGI seven months later (May 2021). The mean age was 17.65 and they represented golf and handball. (3) Results: The CGT contained four main categories seven months after the SARS-CoV-2-pandemic outbreak: Social support, Self-discipline, Physical practice and recovery and Management of everyday life. Fourteen months after the SARS-CoV-2-pandemic outbreak, four additional main categories emerged: More extensive social support, Belief in the future, Self-awareness and Responsibility and problem-solving. (4) Conclusions: The CTG suggests that student-athletes' favorable adaptations to the stressful SARS-CoV-2-pandemic period 2020-2021 are based on a gradually developed ability to take responsibility for one's own actions, insight into the importance of deepened social interaction, belief in a positive post-COVID future and increased awareness of physical activity and its relation to perceived health.", "doi": "10.3390/ijerph191912512", "pmid": "36231812", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph191912512"}], "notes": [], "created": "2022-10-17T14:56:32.227Z", "modified": "2022-10-17T14:57:00.351Z"}, {"entity": "publication", "iuid": "7783f0b4be54469c9768b72979029d95", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7783f0b4be54469c9768b72979029d95.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7783f0b4be54469c9768b72979029d95"}}, "title": "Strain on the ICU resources and patient outcomes in the COVID-19 pandemic: A Swedish national registry cohort study.", "authors": [{"family": "Stattin", "given": "Karl", "initials": "K"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Kawati", "given": "Rafael", "initials": "R"}], "type": "journal article", "published": "2022-09-27", "journal": {"title": "Eur J Anaesthesiol", "issn": "1365-2346", "issn-l": null}, "abstract": "The Coronavirus 2019 (COVID-19) pandemic has led to an unprecedented strain on the ICU resources. It is not known how the ICU resources employed in treating COVID-19 patients are related to inpatient characteristics, use of organ support or mortality.\n\nTo investigate how the use of ICU resources relate to use of organ support and mortality in COVID-19 patients.\n\nA national register-based cohort study.\n\nAll Swedish ICUs from March 2020 to November 2021.\n\nAll patients admitted to Swedish ICUs with a primary diagnosis of COVID-19 reported to the national Swedish Intensive Care Register (SIR).\n\nOrgan support (mechanical ventilation, noninvasive ventilation, high-flow oxygen therapy, prone positioning, surgical and percutaneous tracheostomy, central venous catheterisation, continuous renal replacement therapy and intermittent haemodialysis), discharge at night, re-admission, transfer and ICU and 30-day mortality.\n\nSeven thousand nine hundred and sixty-nine patients had a median age of 63 years, and 70% were men. Median daily census was 167% of habitual census, daily new admissions were 20% of habitual census and the median occupancy was 82%. Census and new admissions were associated with mechanical ventilation, OR 1.37 (95% CI 1.28 to 1.48) and OR 1.44 (95% CI 1.13 to 1.84), respectively, but negatively associated with noninvasive ventilation, OR 0.83 (95% CI 0.77 to 0.89) and OR 0.40 (95% CI 0.30 to 52) and high-flow oxygen therapy, OR 0.72 (95% CI 0.67 to 0.77) and OR 0.77 (95% CI 0.61 to 0.97). Occupancy above 90% of available beds was not associated with mechanical ventilation or noninvasive ventilation, but with high-flow oxygen therapy, OR 1.36 (95% CI 1.21 to 1.53). All measures of pressure on resources were associated with transfer to other hospitals, but none were associated with discharge at night, ICU mortality or 30-day mortality.\n\nPressure on ICU resources was associated with more invasive respiratory support, indicating that during these times, ICU resources were reserved for sicker patients.", "doi": "10.1097/EJA.0000000000001760", "pmid": "36156044", "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00003643-990000000-00037"}], "notes": [], "created": "2022-10-13T13:40:52.395Z", "modified": "2022-10-13T13:40:52.407Z"}, {"entity": "publication", "iuid": "1af31fe1dd4e4ce093745b83c68d4e4b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1af31fe1dd4e4ce093745b83c68d4e4b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1af31fe1dd4e4ce093745b83c68d4e4b"}}, "title": "A comparison of impact of comorbidities and demographics on 60-day mortality in ICU patients with COVID-19, sepsis and acute respiratory distress syndrome.", "authors": [{"family": "Ahlstr\u00f6m", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0001-9287-3607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0606fea9cd1048b99690f2e2823004ce.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Larsson", "given": "Ing-Marie", "initials": "I"}, {"family": "Strandberg", "given": "Gunnar", "initials": "G"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}], "type": "journal article", "published": "2022-09-20", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "12", "issue": "1", "pages": "15703"}, "abstract": "Severe Coronavirus disease 2019 (COVID-19) is associated with several pre-existing comorbidities and demographic factors. Similar factors are linked to critical sepsis and acute respiratory distress syndrome (ARDS). We hypothesized that age and comorbidities are more generically linked to critical illness mortality than a specific disease state. We used national databases to identify ICU patients and to retrieve comorbidities. The relative importance of risk factors for 60-day mortality was evaluated using the interaction with disease group (Sepsis, ARDS or COVID-19) in logistic regression models. We included 32,501 adult ICU patients. In the model on 60-day mortality in sepsis and COVID-19 there were significant interactions with disease group for age, sex and asthma. In the model on 60-day mortality in ARDS and COVID-19 significant interactions with cohort were found for acute disease severity, age and chronic renal failure. In conclusion, age and sex play particular roles in COVID-19 mortality during intensive care but the burden of comorbidity was similar between sepsis and COVID-19 and ARDS and COVID-19.", "doi": "10.1038/s41598-022-19539-0", "pmid": "36127433", "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-19539-0"}, {"db": "pmc", "key": "PMC9487845"}], "notes": [], "created": "2022-10-13T13:37:40.483Z", "modified": "2022-10-13T14:41:17.868Z"}, {"entity": "publication", "iuid": "17fb7d6b29a641868a32c5a8e7493ae5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/17fb7d6b29a641868a32c5a8e7493ae5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/17fb7d6b29a641868a32c5a8e7493ae5"}}, "title": "The amount of SARS-CoV-2 RNA in wastewater relates to the development of the pandemic and its burden on the health system.", "authors": [{"family": "Wang", "given": "Hao", "initials": "H"}, {"family": "Churqui", "given": "Marianela Patzi", "initials": "MP"}, {"family": "Tunovic", "given": "Timur", "initials": "T"}, {"family": "Enache", "given": "Lucica", "initials": "L"}, {"family": "Johansson", "given": "Anette", "initials": "A"}, {"family": "K\u00e4rmander", "given": "Ambj\u00f6rn", "initials": "A"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Dotevall", "given": "Leif", "initials": "L"}, {"family": "Brezicka", "given": "Thomas", "initials": "T"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Norder", "given": "Hel\u00e9ne", "initials": "H"}], "type": "journal article", "published": "2022-09-16", "journal": {"title": "iScience", "issn": "2589-0042", "volume": "25", "issue": "9", "pages": "105000", "issn-l": "2589-0042"}, "abstract": "Virus surveillance in wastewater can be a useful indicator of the development of the COVID-19 pandemic in communities. However, knowledge about how the amount of SARS-CoV-2 RNA in wastewater relates to different data on the burden on the health system is still limited. Herein, we monitored the amount of SARS-CoV-2 RNA and the spectrum of virus variants in weekly pooled wastewater samples for two years from mid-February 2020 and compared them with several clinical data. The two-year monitoring showed the weekly changes in the amount of viral RNA in wastewater preceded the hospital care needs for COVID-19 and the number of acute calls on adult acute respiratory distress by 1-2 weeks during the first three waves of COVID-19. Our study demonstrates that virus surveillance in wastewater can predict the development of a pandemic and its burden on the health system, regardless of society's test capacity and possibility of tracking infected cases.", "doi": "10.1016/j.isci.2022.105000", "pmid": "36035197", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(22)01272-X"}, {"db": "pmc", "key": "PMC9398557"}], "notes": [], "created": "2022-10-07T12:44:32.188Z", "modified": "2022-10-07T12:44:57.950Z"}, {"entity": "publication", "iuid": "198df304734544bd97b1dd4d65203aae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/198df304734544bd97b1dd4d65203aae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/198df304734544bd97b1dd4d65203aae"}}, "title": "Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination.", "authors": [{"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Cai", "given": "Curtis", "initials": "C"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Niessl", "given": "Julia", "initials": "J"}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Lange", "given": "Joshua", "initials": "J"}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Mielke", "given": "Stephan", "initials": "S"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "Vesterbacka", "given": "Jan", "initials": "J"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Perez-Potti", "given": "Andre", "initials": "A"}, {"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "M\u00fcller", "given": "Thomas R", "initials": "TR"}, {"family": "Boulouis", "given": "Caroline", "initials": "C"}, {"family": "Kammann", "given": "Tobias", "initials": "T"}, {"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Muvva", "given": "Jagadeeswara Rao", "initials": "JR"}, {"family": "Sobkowiak", "given": "Michal", "initials": "M"}, {"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "S\u00f6derdahl", "given": "Gunnar", "initials": "G"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Grifoni", "given": "Alba", "initials": "A"}, {"family": "Weiskopf", "given": "Daniela", "initials": "D"}, {"family": "Sette", "given": "Alessandro", "initials": "A"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}], "type": "journal article", "published": "2022-09-13", "journal": {"title": "Immunity", "issn": "1074-7613", "issn-l": null, "volume": "55", "issue": "9", "pages": "1732-1746.e5"}, "abstract": "Many immunocompromised patients mount suboptimal humoral immunity after SARS-CoV-2 mRNA vaccination. Here, we assessed the single-cell profile of SARS-CoV-2-specific T cells post-mRNA vaccination in healthy individuals and patients with various forms of immunodeficiencies. Impaired vaccine-induced cell-mediated immunity was observed in many immunocompromised patients, particularly in solid-organ transplant and chronic lymphocytic leukemia patients. Notably, individuals with an inherited lack of mature B cells, i.e., X-linked agammaglobulinemia (XLA) displayed highly functional spike-specific T cell responses. Single-cell RNA-sequencing further revealed that mRNA vaccination induced a broad functional spectrum of spike-specific CD4+ and CD8+ T cells in healthy individuals and patients with XLA. These responses were founded on polyclonal repertoires of CD4+ T cells and robust expansions of oligoclonal effector-memory CD45RA+ CD8+ T cells with stem-like characteristics. Collectively, our data provide the functional continuum of SARS-CoV-2-specific T cell responses post-mRNA vaccination, highlighting that cell-mediated immunity is of variable functional quality across immunodeficiency syndromes.", "doi": "10.1016/j.immuni.2022.07.005", "pmid": "35961317", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Research Area: Pandemic preparedness": null}, "xrefs": [{"db": "pmc", "key": "PMC9293955"}, {"db": "pii", "key": "S1074-7613(22)00338-7"}], "notes": [], "created": "2022-08-15T15:03:48.087Z", "modified": "2023-06-19T15:22:45.168Z"}, {"entity": "publication", "iuid": "914b9bc1bcef42d38359a1786dd84dcf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/914b9bc1bcef42d38359a1786dd84dcf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/914b9bc1bcef42d38359a1786dd84dcf"}}, "title": "Genetic and immunologic evaluation of children with inborn errors of immunity and severe or critical COVID-19.", "authors": [{"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Delavari", "given": "Samaneh", "initials": "S"}, {"family": "Landegren", "given": "Nils", "initials": "N"}, {"family": "Shokri", "given": "Sima", "initials": "S"}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Zuo", "given": "Fanglei", "initials": "F"}, {"family": "Hajebi", "given": "Reza", "initials": "R"}, {"family": "Abolnezhadian", "given": "Farhad", "initials": "F"}, {"family": "Iranparast", "given": "Sara", "initials": "S"}, {"family": "Modaresi", "given": "Mohammadreza", "initials": "M"}, {"family": "Vosughimotlagh", "given": "Ahmad", "initials": "A"}, {"family": "Salami", "given": "Fereshte", "initials": "F"}, {"family": "Aranda-Guill\u00e9n", "given": "Maribel", "initials": "M"}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A"}, {"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "S"}, {"family": "Zhang", "given": "Qian", "initials": "Q"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "J"}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}], "type": "journal article", "published": "2022-09-13", "journal": {"title": "J Allergy Clin Immunol", "issn": "1097-6825", "issn-l": "0091-6749", "volume": null, "issue": null, "pages": null}, "abstract": "Most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals are asymptomatic or only exhibit mild disease. In about 10% of cases, the infection leads to hypoxemic pneumonia, although it is much more rare in children.\r\n\r\nWe evaluated 31 young patients aged 0.5 to 19 years who had preexisting inborn errors of immunity (IEI) but lacked a molecular diagnosis and were later diagnosed with coronavirus disease 2019 (COVID-19) complications.\r\n\r\nGenetic evaluation by whole-exome sequencing was performed in all patients. SARS-CoV-2-specific antibodies, autoantibodies against type I IFN (IFN-I), and inflammatory factors in plasma were measured. We also reviewed COVID-19 disease severity/outcome in reported IEI patients.\r\n\r\nA potential genetic cause of the IEI was identified in 28 patients (90.3%), including mutations that may affect IFN signaling, T- and B-cell function, the inflammasome, and the complement system. From tested patients 65.5% had detectable virus-specific antibodies, and 6.8% had autoantibodies neutralizing IFN-I. Five patients (16.1%) fulfilled the diagnostic criteria of multisystem inflammatory syndrome in children. Eleven patients (35.4%) died of COVID-19 complications. All together, at least 381 IEI children with COVID-19 have been reported in the literature to date. Although many patients with asymptomatic or mild disease may not have been reported, severe presentation of COVID-19 was observed in 23.6% of the published cases, and the mortality rate was 8.7%.\r\n\r\nYoung patients with preexisting IEI may have higher mortality than children without IEI when infected with SARS-CoV-2. Elucidating the genetic basis of IEI patients with severe/critical COVID-19 may help to develop better strategies for prevention and treatment of severe COVID-19 disease and complications in pediatric patients.", "doi": "10.1016/j.jaci.2022.09.005", "pmid": "36113674", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "S0091-6749(22)01185-X"}, {"db": "pmc", "key": "PMC9472457"}], "notes": [], "created": "2022-10-13T13:32:35.129Z", "modified": "2022-10-13T13:34:58.395Z"}, {"entity": "publication", "iuid": "445377ec34e046d7a5d2375bd676828e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/445377ec34e046d7a5d2375bd676828e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/445377ec34e046d7a5d2375bd676828e"}}, "title": "COVID-19 is associated with bystander polyclonal autoreactive B cell activation as reflected by a broad autoantibody production, but none is linked to disease severity.", "authors": [{"family": "Jiang", "given": "Wei", "initials": "W", "orcid": "0000-0002-1374-053X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b3788374c8a4b83a5d94577fa1ff933.json"}}, {"family": "Johnson", "given": "Douglas", "initials": "D"}, {"family": "Adekunle", "given": "Ruth", "initials": "R"}, {"family": "Heather", "given": "Hughes", "initials": "H"}, {"family": "Xu", "given": "Wanli", "initials": "W"}, {"family": "Cong", "given": "Xiaomei", "initials": "X"}, {"family": "Wu", "given": "Xueling", "initials": "X"}, {"family": "Fan", "given": "Hongkuan", "initials": "H"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "L"}, {"family": "Robertson", "given": "Josefina", "initials": "J"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2022-09-10", "journal": {"title": "J Med Virol", "issn": "1096-9071", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Coronavirus disease 2019 (COVID-19) is associated with autoimmune features and autoantibody production in a small subset of the population. Pre-existing neutralizing antitype I interferons (IFNs) autoantibodies are related to the severity of COVID-19. Plasma levels of IgG and IgM against 12 viral antigens and 103 self-antigens were evaluated using an antibody protein array in patients with severe/critical or mild/moderate COVID-19 disease and uninfected controls. Patients exhibited increased IgGs against Severe acute respiratory syndrome coronavirus-2 proteins compared to controls, but no difference was observed in the two patient groups. 78% autoreactive IgGs and 93% autoreactive IgMs were increased in patients versus controls. There was no difference in the plasma levels of anti-type I IFN autoantibodies or neutralizing anti-type I IFN activity of plasma samples from the two patient groups. Increased anti-type I IFN IgGs were correlated with higher lymphocyte accounts, suggesting a role of nonpathogenic autoantibodies. Notably, among the 115 antibodies tested, only plasma levels of IgGs against human coronavirus (HCOV)-229E and HCOV-NL63 spike proteins were associated with mild disease outcome. COVID-19 was associated with a bystander polyclonal autoreactive B cell activation, but none of the autoantibody levels were linked to disease severity. Long-term humoral immunity against HCOV-22E and HCOV-NL63 spike protein was associated with mild disease outcome. Understanding the mechanism of life-threatening COVID-19 is critical to reducing mortality and morbidity.", "doi": "10.1002/jmv.28134", "pmid": "36086941", "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9538121"}], "notes": [], "created": "2022-10-13T13:27:53.034Z", "modified": "2022-10-13T14:41:54.606Z"}, {"entity": "publication", "iuid": "cfc18a5797b240c0920df270cb4586db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfc18a5797b240c0920df270cb4586db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfc18a5797b240c0920df270cb4586db"}}, "title": "Thrombosis with thrombocytopenia after AZD1222 (ChAdOx1 nCov-19) vaccination: Case characteristics and associations.", "authors": [{"family": "Laffan", "given": "Michael A", "initials": "MA"}, {"family": "Rees", "given": "Sue", "initials": "S"}, {"family": "Yadavalli", "given": "Madhavi", "initials": "M"}, {"family": "Ferstenberg", "given": "Lisa Beth", "initials": "LB"}, {"family": "Kumar Shankar", "given": "Nirmal", "initials": "N"}, {"family": "Medin", "given": "Jennie", "initials": "J"}, {"family": "Foskett", "given": "Nadia", "initials": "N"}, {"family": "Arnold", "given": "Matthew", "initials": "M"}, {"family": "Gomes da Silva", "given": "Hugo", "initials": "H"}, {"family": "Bhuyan", "given": "Prakash", "initials": "P"}, {"family": "Nord", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2022-09-09", "journal": {"title": "Vaccine", "issn": "1873-2518", "volume": "40", "issue": "38", "pages": "5585-5593", "issn-l": null}, "abstract": "Post-marketing surveillance for COVID-19 vaccines during the pandemic identified an extremely rare thrombosis with thrombocytopenia syndrome (TTS) reported post-vaccination, requiring further characterisation to improve diagnosis and management.\n\nWe searched the AstraZeneca Global Safety Database (through April 26, 2021) for cases with co-reported thrombocytopenia and thrombosis (using standardised MedDRA queries/high-level terms) following AZD1222 (ChAdOx1 nCoV-19). Cases were adjudicated by experts as 'typical','possible', 'no' or 'unknown' according to available TTS criteria. Additional confirmatory datasets (May 20-June 20, October 1-December 28) were evaluated.\n\nWe identified 573 reports, including 273 (47.6 %) 'typical' and 171 (29.8 %) 'possible' TTS cases. Of these 444 cases, 275 (61.9 %) were female, median age was 50.0 years (IQR: 38.0-60.0). Cerebral venous sinus thrombosis was reported in 196 (44.1 %) cases, splanchnic venous thrombosis in 65 (14.6 %) and thromboses at multiple sites in 119 (26.8 %). Median time to onset was 12.0 days (IQR: 9.0-15.0). Comparison with a pre-pandemic reference population indicated higher rates of autoimmune disorders (13.8 %, 4.4 %), previous heparin therapy (7.4 %, 1.2 %), history of thrombosis (5.5 %, 1.4 %), and immune thrombocytopenia (6.1 %, 0.2 %). Fatality rate was 22.2 % (127/573) overall and 23.6 % (105/444) in 'typical'/'possible' TTS, which decreased from 39.0 % (60/154) in February/March to 15.5 % (45/290) in April. Overall patterns were similar in confirmatory datasets.\n\nThe reporting rate of 'typical'/'possible' TTS post first-dose vaccination in this dataset is 7.5 per million vaccinated persons; few cases were reported after subsequent doses, including booster doses. Peak reporting coincided with media-driven attention. Medical history differences versus a reference population indicate potentially unidentified risk factors. The decreasing fatality rate correlates with increasing awareness and publication of diagnostic/treatment guidelines. Adjudication was hindered by unreported parameters, and an algorithm was developed to classify potential TTS cases; comprehensive reporting could help further improve definition and management of this extremely rare syndrome.", "doi": "10.1016/j.vaccine.2022.08.007", "pmid": "35989136", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(22)00964-1"}, {"db": "pmc", "key": "PMC9388294"}], "notes": [], "created": "2022-09-12T18:49:59.431Z", "modified": "2022-09-12T18:50:20.934Z"}, {"entity": "publication", "iuid": "98c4fad1a2c54587ab229be91b562c70", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/98c4fad1a2c54587ab229be91b562c70.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/98c4fad1a2c54587ab229be91b562c70"}}, "title": "Sialic Acid and Fucose Residues on the SARS-CoV-2 Receptor-Binding Domain Modulate IgG Antibody Reactivity.", "authors": [{"family": "Samuelsson", "given": "Ebba", "initials": "E"}, {"family": "Mirgorodskaya", "given": "Ekaterina", "initials": "E"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "B\u00e4ckstr\u00f6m", "given": "Malin", "initials": "M"}, {"family": "Liljeqvist", "given": "Jan-\u00c5ke", "initials": "J\u00c5"}, {"family": "Nord\u00e9n", "given": "Rickard", "initials": "R", "orcid": "0000-0002-3866-7228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/270f5cf52d6544a78dc4bde1bf1e97a2.json"}}], "type": "journal article", "published": "2022-09-09", "journal": {"title": "ACS Infect Dis", "issn": "2373-8227", "volume": "8", "issue": "9", "pages": "1883-1893", "issn-l": null}, "abstract": "The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is a conserved domain and a target for neutralizing antibodies. We defined the carbohydrate content of the recombinant RBD produced in different mammalian cells. We found a higher degree of complex-type N-linked glycans, with less sialylation and more fucosylation, when the RBD was produced in human embryonic kidney cells compared to the same protein produced in Chinese hamster ovary cells. The carbohydrates on the RBD proteins were enzymatically modulated, and the effect on antibody reactivity was evaluated with serum samples from SARS-CoV-2 positive patients. Removal of all carbohydrates diminished antibody reactivity, while removal of only sialic acids or terminal fucoses improved the reactivity. The RBD produced in Lec3.2.8.1-cells, which generate carbohydrate structures devoid of sialic acids and with reduced fucose content, exhibited enhanced antibody reactivity, verifying the importance of these specific monosaccharides. The results can be of importance for the design of future vaccine candidates, indicating that it is possible to enhance the immunogenicity of recombinant viral proteins.", "doi": "10.1021/acsinfecdis.2c00155", "pmid": "35980012", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:42:27.556Z", "modified": "2022-09-12T18:42:50.047Z"}, {"entity": "publication", "iuid": "968c86731eb34291987dde45dbc6e055", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/968c86731eb34291987dde45dbc6e055.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/968c86731eb34291987dde45dbc6e055"}}, "title": "Recovering from COVID-19 - A Process Characterised by Uncertainty: A Qualitative study.", "authors": [{"family": "Engwall", "given": "Marie", "initials": "M"}, {"family": "T\u00f6rnbom", "given": "Karin", "initials": "K"}, {"family": "Persson", "given": "Hanna C", "initials": "HC"}, {"family": "Palstam", "given": "Annie", "initials": "A"}], "type": "journal article", "published": "2022-09-09", "journal": {"title": "J Rehabil Med", "issn": "1651-2081", "volume": "54", "pages": "jrm00326", "issn-l": null}, "abstract": "To obtain a deeper understanding of the lived experiences of patients with COVID-19, the recovery process and consequences for everyday life 6 months after hospital discharge.\n\nAn explorative qualitative study using individual interviews.\n\nA purposive sampling was applied to recruit persons who had received inpatient hospital care, were discharged approximately 6 months previously, were of working age and had persistent self-reported symptoms at a 3-month follow-up appointment.\n\nSemi-structured interviews were conducted with 15 participants (10 men, 5 women), which were then transcribed and analysed with inductive thematic analysis.\n\nThree themes were identified: \"Status of recovery - two steps forward, one step back\", \"Remaining symptoms caused limitations in everyday life\" and \"Strategies for recovery\". Participants indicated the recovery process through 6 months after discharge was a challenging road, often involving setbacks. A wide range of persistent, fluctuating, or new symptoms negatively impacted many areas of daily life, with fatigue and lack of energy being especially prominent. Participants used a variety of strategies to cope and recover.\n\nThis study increases our knowledge of the lived experiences of COVID-19 based individual experiences. Unexpected symptoms in the recovery process were described and not always possible to forecast.", "doi": "10.2340/jrm.v54.2739", "pmid": "35976769", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:39:02.356Z", "modified": "2022-09-12T18:39:02.362Z"}, {"entity": "publication", "iuid": "79254181a0ab4b0ca26323a6deb65af0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79254181a0ab4b0ca26323a6deb65af0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79254181a0ab4b0ca26323a6deb65af0"}}, "title": "Monitoring of the SARS-CoV-2 Omicron BA.1/BA.2 lineage transition in the Swedish population reveals increased viral RNA levels in BA.2 cases.", "authors": [{"family": "Lentini", "given": "Antonio", "initials": "A"}, {"family": "Pereira", "given": "Antonio", "initials": "A"}, {"family": "Winqvist", "given": "Ola", "initials": "O"}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-7021-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9eef54f4e0534805b173cfae62a75d55.json"}}], "type": "case reports", "published": "2022-09-09", "journal": {"title": "Med (N Y)", "issn": "2666-6340", "issn-l": null, "volume": "3", "issue": "9", "pages": "636-643.e4"}, "abstract": "Throughout the SARS-CoV-2 pandemic, multiple waves of variants of concern have swept across populations, leading to a chain of new and yet more contagious variants dominating COVID-19 cases. Here, we tracked the remarkably rapid shift from Omicron BA.1 to BA.2 sublineage dominance in the Swedish population in early 2022 at a day-by-day basis.\n\nUsing a custom SARS-CoV-2 Omicron BA.1 lineage-typing RT-PCR assay, we analyzed 174,933 clinical upper airway samples collected during January to March 2022.\n\nOur study demonstrates the feasibility and reliability of parallel lineage assignment of select variants at population scale, tracking the dominant sublineage transition from BA.1 to BA.2 at day-to-day resolution and uncovering nearly 2-fold higher levels of viral RNA in cases infected with Omicron BA.2 relative to BA.1.\n\nOur data provide unique insights into the Omicron BA.1 to BA.2 transition that occurred in Sweden during early 2022, and later, across the world. This may help to understand the increased transmissibility of the BA.2 variant.", "doi": "10.1016/j.medj.2022.07.007", "pmid": "35981541", "labels": {"Category: Health": null, "Category: Omicron VoC": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9359497"}, {"db": "pii", "key": "S2666-6340(22)00317-8"}], "notes": [], "created": "2022-03-28T10:31:50.830Z", "modified": "2023-06-19T15:01:12.299Z"}, {"entity": "publication", "iuid": "c73f45508d7b4fb995f7ceccefa7a93d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c73f45508d7b4fb995f7ceccefa7a93d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c73f45508d7b4fb995f7ceccefa7a93d"}}, "title": "Back to life: Is it possible to be myself again? A qualitative study with persons initially hospitalised due to COVID-19.", "authors": [{"family": "T\u00f6rnbom", "given": "Karin", "initials": "K"}, {"family": "Engwall", "given": "Marie", "initials": "M"}, {"family": "Persson", "given": "Hanna C", "initials": "HC"}, {"family": "Palstam", "given": "Annie", "initials": "A"}], "type": "journal article", "published": "2022-09-09", "journal": {"title": "J Rehabil Med", "issn": "1651-2081", "volume": "54", "pages": "jrm00327", "issn-l": null}, "abstract": "To gain a deeper understanding of the lived experiences of patients with COVID-19, regarding rehabilitation, work and social life 6 months after hospital discharge.\n\nAn explorative qualitative study with individual interviews.\n\nPatients of working age with persistent self-reported symptoms at a 3-month follow-up who had received inpatient hospital care with discharge approximately 6 months previously were purposively sampled.\n\nSemi-structured interviews were performed with 10 men and 5 women. The interviews were transcribed verbatim and analysed with inductive thematic analysis.\n\nFour themes were identified: \"Social support - crucial, but decreased over time\", \"Varying needs of, and access to, rehabilitation\", \"Returning to work after COVID-19 - crucial for future prospects\" and \"An overwhelming experience that essentially changed one's personality\".\n\nRehabilitation provided participants with the valuable tools for recovery, giving them hope for future recovery. Support from next of kin was highly valued, creating stronger family bonds. A new meaning and greater appreciation of life was expressed.", "doi": "10.2340/jrm.v54.2742", "pmid": "35976766", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:38:30.988Z", "modified": "2022-09-12T18:38:30.993Z"}, {"entity": "publication", "iuid": "3468fd2046304320ab7fc4fbe3c66355", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3468fd2046304320ab7fc4fbe3c66355.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3468fd2046304320ab7fc4fbe3c66355"}}, "title": "Spatio-temporal predictions of COVID-19 test positivity in Uppsala County, Sweden: a comparative approach.", "authors": [{"family": "van Zoest", "given": "Vera", "initials": "V", "orcid": "0000-0002-3017-0874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72aee535dc8c45478a4cf678e01d2421.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G"}, {"family": "Menzel", "given": "Uwe", "initials": "U"}, {"family": "Wigren", "given": "Anders", "initials": "A"}, {"family": "Kennedy", "given": "Beatrice", "initials": "B", "orcid": "0000-0002-0066-4814", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d3a346caa424c4dad653097b2518efb.json"}}, {"family": "Martinell", "given": "Mats", "initials": "M"}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f34c0d3602439abe6096293c7c732d.json"}}], "type": "journal article", "published": "2022-09-07", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "15176", "issn-l": "2045-2322"}, "abstract": "Previous spatio-temporal COVID-19 prediction models have focused on the prediction of subsequent number of cases, and have shown varying accuracy and lack of high geographical resolution. We aimed to predict trends in COVID-19 test positivity, an important marker for planning local testing capacity and accessibility. We included a full year of information (June 29, 2020-July 4, 2021) with both direct and indirect indicators of transmission, e.g. mobility data, number of calls to the national healthcare advice line and vaccination coverage from Uppsala County, Sweden, as potential predictors. We developed four models for a 1-week-window, based on gradient boosting (GB), random forest (RF), autoregressive integrated moving average (ARIMA) and integrated nested laplace approximations (INLA). Three of the models (GB, RF and INLA) outperformed the na\u00efve baseline model after data from a full pandemic wave became available and demonstrated moderate accuracy. An ensemble model of these three models slightly improved the average root mean square error to 0.039 compared to 0.040 for GB, RF and INLA, 0.055 for ARIMA and 0.046 for the na\u00efve model. Our findings indicate that the collection of a wide variety of data can contribute to spatio-temporal predictions of COVID-19 test positivity.", "doi": "10.1038/s41598-022-19155-y", "pmid": "36071066", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-19155-y"}, {"db": "pmc", "key": "PMC9450842"}], "notes": [], "created": "2022-10-13T13:26:00.407Z", "modified": "2022-10-13T13:26:21.845Z"}, {"entity": "publication", "iuid": "7e7de2c58ea7451fa5926a0741e07232", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e7de2c58ea7451fa5926a0741e07232.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e7de2c58ea7451fa5926a0741e07232"}}, "title": "Protection against SARS-CoV-2 transmission by a parenteral prime-Intranasal boost vaccine strategy.", "authors": [{"family": "Christensen", "given": "Dennis", "initials": "D"}, {"family": "Polacek", "given": "Charlotta", "initials": "C"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Moliner-Morro", "given": "Ainhoa", "initials": "A"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Hartmann", "given": "Katrine Top", "initials": "KT"}, {"family": "Jensen", "given": "Henrik Elvang", "initials": "HE"}, {"family": "Jungersen", "given": "Gregers", "initials": "G"}, {"family": "Illigen", "given": "Kristin", "initials": "K"}, {"family": "Isling", "given": "Louise Krag", "initials": "LK"}, {"family": "Jensen", "given": "Rune Fledelius", "initials": "RF"}, {"family": "Hansen", "given": "Julia Sid", "initials": "JS"}, {"family": "Rosenkrands", "given": "Ida", "initials": "I"}, {"family": "Fernandez-Antunez", "given": "Carlota", "initials": "C"}, {"family": "Ramirez", "given": "Santseharay", "initials": "S"}, {"family": "Follmann", "given": "Frank", "initials": "F"}, {"family": "Bukh", "given": "Jens", "initials": "J"}, {"family": "Pedersen", "given": "Gabriel Kristian", "initials": "GK"}], "type": "journal article", "published": "2022-09-05", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": null, "issue": null, "pages": "104248"}, "abstract": "Licensed vaccines against SARS-CoV-2 effectively protect against severe disease, but display incomplete protection against virus transmission. Mucosal vaccines providing immune responses in the upper airways are one strategy to protect against transmission.\r\n\r\nWe administered Spike HexaPro trimer formulated in a cationic liposomal adjuvant as a parenteral (subcutaneous - s.c.) prime - intranasal boost regimen to elicit airway mucosal immune responses and evaluated this in a Syrian hamster model of virus transmission.\r\n\r\nParenteral prime - intranasal boost elicited high-magnitude serum neutralizing antibody responses and IgA responses in the upper respiratory tract. The vaccine strategy protected against virus in the lower airways and lung pathology, but virus could still be detected in the upper airways. Despite this, the parenteral prime - intranasal booster vaccine effectively protected against onward SARS-CoV-2 transmission.\r\n\r\nThis study suggests that parenteral-prime mucosal boost is an effective strategy for protecting against SARS-CoV-2 infection and highlights that protection against virus transmission may be obtained despite incomplete clearance of virus from the upper respiratory tract. It should be noted that protection against onward transmission was not compared to standard parenteral prime-boost, which should be a focus for future studies.\r\n\r\nThis work was primarily supported by the European Union Horizon 2020 research and innovation program under grant agreement no. 101003653.", "doi": "10.1016/j.ebiom.2022.104248", "pmid": "36088218", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "S2352-3964(22)00430-3"}], "notes": [], "created": "2022-09-12T19:32:33.868Z", "modified": "2022-09-12T19:33:52.615Z"}, {"entity": "publication", "iuid": "d20e1200b5a14722a7cf1ef691ea52dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d20e1200b5a14722a7cf1ef691ea52dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d20e1200b5a14722a7cf1ef691ea52dd"}}, "title": "Cross-direct effects in settings with two mediators.", "authors": [{"family": "Gabriel", "given": "Erin E", "initials": "EE", "orcid": "0000-0002-0504-8404", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a390da0ea8a54bf6a7eec1aec5959ba2.json"}}, {"family": "Sj\u00f6lander", "given": "Arvid", "initials": "A", "orcid": "0000-0001-5226-6685", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9de77f267804d99b19c0e47237cf413.json"}}, {"family": "Follmann", "given": "Dean", "initials": "D"}, {"family": "Sachs", "given": "Michael C", "initials": "MC", "orcid": "0000-0002-1279-8676", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e1b0576ba84040bb393a4ecee4cb3b.json"}}], "type": "journal article", "published": "2022-09-02", "journal": {"title": "Biostatistics", "issn": "1468-4357", "issn-l": null}, "abstract": "When multiple mediators are present, there are additional effects that may be of interest beyond the well-known natural (NDE) and controlled direct effects (CDE). These effects cross the type of control on the mediators, setting one to a constant level and one to its natural level, which differs across subjects. We introduce five such estimands for the cross-CDE and -NDE when two mediators are measured. We consider both the scenario where one mediator is influenced by the other, referred to as sequential mediators, and the scenario where the mediators do not influence each other. Such estimands may be of interest in immunology, as we discuss in relation to measured immunological responses to SARS-CoV-2 vaccination. We provide identifying expressions for the estimands in observational settings where there is no residual confounding, and where intervention, outcome, and mediators are of arbitrary type. We further provide tight symbolic bounds for the estimands in randomized settings where there may be residual confounding of the outcome and mediator relationship and all measured variables are binary.", "doi": "10.1093/biostatistics/kxac037", "pmid": "36050911", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6684013"}], "notes": [], "created": "2022-10-13T13:18:27.085Z", "modified": "2022-10-13T13:18:52.493Z"}, {"entity": "publication", "iuid": "c43434d2bca64fc8af96906e2c5fbccf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c43434d2bca64fc8af96906e2c5fbccf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c43434d2bca64fc8af96906e2c5fbccf"}}, "title": "\"Role of kidney function and concentrations of BAFF, sPD-L1 and sCD25 on mortality in hospitalized patients with COVID-19\".", "authors": [{"family": "Mansouri", "given": "Ladan", "initials": "L"}, {"family": "Sendic", "given": "Senka", "initials": "S"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Jacobson", "given": "Stefan H", "initials": "SH"}, {"family": "Lundahl", "given": "Joachim", "initials": "J"}], "type": "journal article", "published": "2022-09-02", "journal": {"title": "BMC Nephrol", "issn": "1471-2369", "volume": "23", "issue": "1", "pages": "299", "issn-l": null}, "abstract": "Chronic kidney disease (CKD) is a recognized risk factor for severe complications in COVID-19. Our objective was to analyze the association between kidney function / T and B lymphocyte modulatory factors and risk of mortality in COVID-19 patients.\n\nIn-hospital and 30-day mortality were analyzed in COVID-19 patients (n = 110). Plasma levels of selected T and B cell modulators were analyzed and correlated to mortality risk. A subgroup of sex- and eGFR-matched COVID-19 patients was compared to CKD patients without infection and healthy subjects.\n\nCOVID-19 patients who died in hospital and within 30 days had significantly higher BAFF and sCD25 plasma levels than survivors. In logistic regression models patients with high BAFF, sCD25 and sPD-L1 levels had significantly higher risk of both in-hospital and 30-day mortality while there was no association to eGFR. In the subgroup analysis, a higher level of BAFF, IFN-\u03b1, sCD25, sPD-L1 and a lower level of sCD40L was observed in COVID-19 patients compared to the CKD group with corresponding kidney function.\n\nWe demonstrate that kidney function and concentrations of BAFF, sCD25 and PD-L1, independent of previously recognized risk factors; age, male gender, and leukocytosis are associated with risk of in-hospital and 30-day mortality in patients with COVID-19. These data indicate the significance of adaptive immune system modulators in COVID-19 and motivate further analysis to identify new potential prognostic and therapeutic approaches.", "doi": "10.1186/s12882-022-02924-2", "pmid": "36056305", "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12882-022-02924-2"}, {"db": "pmc", "key": "PMC9438228"}], "notes": [], "created": "2022-10-13T13:22:06.214Z", "modified": "2022-10-13T13:22:06.226Z"}, {"entity": "publication", "iuid": "023f130b0f164fcfb08ed1472c1bee2d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/023f130b0f164fcfb08ed1472c1bee2d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/023f130b0f164fcfb08ed1472c1bee2d"}}, "title": "International Perspectives on the Impact of the COVID-19 Pandemic on Adherence to Prescribed Dual Antiplatelet Therapy: A Window Into Acute Cardiovascular Care.", "authors": [{"family": "Pollack", "given": "Charles V", "initials": "CV"}, {"family": "Steg", "given": "P Gabriel", "initials": "PG"}, {"family": "James", "given": "Stefan", "initials": "S"}, {"family": "Jolly", "given": "Sanjit", "initials": "S"}, {"family": "Kosiborod", "given": "Mikhail", "initials": "M"}, {"family": "Bonaca", "given": "Marc P", "initials": "MP"}], "type": "journal article", "published": "2022-09-01", "journal": {"title": "Crit Pathw Cardiol", "issn": "1535-2811", "volume": "21", "issue": "3", "pages": "114-122", "issn-l": null}, "abstract": "An international panel of expert clinicians and researchers in acute cardiac care was convened to review, describe, and contextualize their varied experiences delivering care and maintaining ongoing research during the first year of the COVID-19 pandemic and beyond. A proposed perspective from which care and outcomes could be viewed was the possibility that without routine follow-up and as-accustomed interactions with their care team, patients at risk of acute atherothrombotic events might be less adherent to prescribed antiplatelet medications. This might be manifested by more emergency coronary events or by an increased (and perhaps unidentifiable) incidence of out-of-hospital cardiovascular deaths related to patient anxiety about presenting to hospital during the pandemic. The experiences of the panel members were similar in many regards, which identified opportunities for improvement in cardiac care the next time there is a substantial disruption of usual practice. Regardless of geography or payor system, there was an identified need for better remote care platforms; but stronger infrastructure and consumer facility with remote care technology, improved provider-patient communication to help ensure adherence to primary and secondary prevention medications, and longer-term prescription fills and no-hassle refills on such medications. Profound disruptions in acute cardiovascular research highlighted the need for redundancy or back-up planning for teams engaged in time-sensitive research, to ensure both continuity of protocols and patient safety.", "doi": "10.1097/HPC.0000000000000292", "pmid": "35994719", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00132577-202209000-00002"}, {"db": "pmc", "key": "PMC9389943"}], "notes": [], "created": "2022-09-12T19:00:10.930Z", "modified": "2022-09-12T19:00:21.855Z"}, {"entity": "publication", "iuid": "1863b4966cc3452b824b91225a55eed6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1863b4966cc3452b824b91225a55eed6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1863b4966cc3452b824b91225a55eed6"}}, "title": "High-dimensional multinomial multiclass severity scoring of COVID-19 pneumonia using CT radiomics features and machine learning algorithms.", "authors": [{"family": "Shiri", "given": "Isaac", "initials": "I"}, {"family": "Mostafaei", "given": "Shayan", "initials": "S"}, {"family": "Haddadi Avval", "given": "Atlas", "initials": "A"}, {"family": "Salimi", "given": "Yazdan", "initials": "Y"}, {"family": "Sanaat", "given": "Amirhossein", "initials": "A"}, {"family": "Akhavanallaf", "given": "Azadeh", "initials": "A"}, {"family": "Arabi", "given": "Hossein", "initials": "H"}, {"family": "Rahmim", "given": "Arman", "initials": "A"}, {"family": "Zaidi", "given": "Habib", "initials": "H"}], "type": "journal article", "published": "2022-09-01", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "14817", "issn-l": "2045-2322"}, "abstract": "We aimed to construct a prediction model based on computed tomography (CT) radiomics features to classify COVID-19 patients into severe-, moderate-, mild-, and non-pneumonic. A total of 1110 patients were studied from a publicly available dataset with 4-class severity scoring performed by a radiologist (based on CT images and clinical features). The entire lungs were segmented and followed by resizing, bin discretization and radiomic features extraction. We utilized two feature selection algorithms, namely bagging random forest (BRF) and multivariate adaptive regression splines (MARS), each coupled to a classifier, namely multinomial logistic regression (MLR), to construct multiclass classification models. The dataset was divided into 50% (555 samples), 20% (223 samples), and 30% (332 samples) for training, validation, and untouched test datasets, respectively. Subsequently, nested cross-validation was performed on train/validation to select the features and tune the models. All predictive power indices were reported based on the testing set. The performance of multi-class models was assessed using precision, recall, F1-score, and accuracy based on the 4 \u00d7 4 confusion matrices. In addition, the areas under the receiver operating characteristic curves (AUCs) for multi-class classifications were calculated and compared for both models. Using BRF, 23 radiomic features were selected, 11 from first-order, 9 from GLCM, 1 GLRLM, 1 from GLDM, and 1 from shape. Ten features were selected using the MARS algorithm, namely 3 from first-order, 1 from GLDM, 1 from GLRLM, 1 from GLSZM, 1 from shape, and 3 from GLCM features. The mean absolute deviation, skewness, and variance from first-order and flatness from shape, and cluster prominence from GLCM features and Gray Level Non Uniformity Normalize from GLRLM were selected by both BRF and MARS algorithms. All selected features by BRF or MARS were significantly associated with four-class outcomes as assessed within MLR (All p values < 0.05). BRF + MLR and MARS + MLR resulted in pseudo-R2 prediction performances of 0.305 and 0.253, respectively. Meanwhile, there was a significant difference between the feature selection models when using a likelihood ratio test (p value = 0.046). Based on confusion matrices for BRF + MLR and MARS + MLR algorithms, the precision was 0.856 and 0.728, the recall was 0.852 and 0.722, whereas the accuracy was 0.921 and 0.861, respectively. AUCs (95% CI) for multi-class classification were 0.846 (0.805-0.887) and 0.807 (0.752-0.861) for BRF + MLR and MARS + MLR algorithms, respectively. Our models based on the utilization of radiomic features, coupled with machine learning were able to accurately classify patients according to the severity of pneumonia, thus highlighting the potential of this emerging paradigm in the prognostication and management of COVID-19 patients.", "doi": "10.1038/s41598-022-18994-z", "pmid": "36050434", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-18994-z"}, {"db": "pmc", "key": "PMC9437017"}], "notes": [], "created": "2022-10-13T13:07:03.780Z", "modified": "2022-10-13T13:07:03.796Z"}, {"entity": "publication", "iuid": "86c2b35ac05c4a20a212e1670b3e12c4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86c2b35ac05c4a20a212e1670b3e12c4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86c2b35ac05c4a20a212e1670b3e12c4"}}, "title": "Decreased renal perfusion during acute kidney injury in critical COVID-19 assessed by magnetic resonance imaging: a prospective case control study.", "authors": [{"family": "Luther", "given": "Tomas", "initials": "T"}, {"family": "Eckerbom", "given": "Per", "initials": "P"}, {"family": "Cox", "given": "Eleanor", "initials": "E"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "B\u00fclow", "given": "Sara", "initials": "S"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Torrente", "given": "Francisco Martinez", "initials": "FM"}, {"family": "Weis", "given": "Jan", "initials": "J"}, {"family": "Palm", "given": "Fredrik", "initials": "F"}, {"family": "Francis", "given": "Susan", "initials": "S"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Liss", "given": "Per", "initials": "P"}], "type": "clinical trial", "published": "2022-09-01", "journal": {"title": "Crit Care", "issn": "1466-609X", "issn-l": "1364-8535", "volume": "26", "issue": "1", "pages": "262"}, "abstract": "Renal hypoperfusion has been suggested to contribute to the development of acute kidney injury (AKI) in critical COVID-19. However, limited data exist to support this. We aim to investigate the differences in renal perfusion, oxygenation and water diffusion using multiparametric magnetic resonance imaging in critically ill COVID-19 patients with and without AKI.\r\n\r\nA prospective case-control study where patients without prior kidney disease treated in intensive care for respiratory failure due to COVID-19 were examined. Kidney Disease: Improving Global Outcomes Creatinine criteria were used for group allocation. Main comparisons were tested using Mann-Whitney U test.\r\n\r\nNineteen patients were examined, ten with AKI and nine without AKI. Patients with AKI were examined in median 1 [0-2] day after criteria fulfillment. Age and baseline Plasma-Creatinine were similar in both groups. Total renal blood flow was lower in patients with AKI compared with patients without (median 645 quartile range [423-753] vs. 859 [746-920] ml/min, p = 0.037). Regional perfusion was reduced in both cortex (76 [51-112] vs. 146 [123-169] ml/100 g/min, p = 0.015) and medulla (28 [18-47] vs. 47 [38-73] ml/100 g/min, p = 0.03). Renal venous saturation was similar in both groups (72% [64-75] vs. 72% [63-84], ns.), as was regional oxygenation (R2*) in cortex (17 [16-19] vs. 17 [16-18] 1/s, ns.) and medulla (29 [24-39] vs. 27 [23-29] 1/s, ns.).\r\n\r\nIn critically ill COVID-19 patients with AKI, the total, cortical and medullary renal blood flows were reduced compared with similar patients without AKI, whereas no differences in renal oxygenation were demonstrable in this setting. Trial registration ClinicalTrials ID: NCT02765191 , registered May 6 2014 and updated May 7 2020.", "doi": "10.1186/s13054-022-04132-8", "pmid": "36050748", "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: VR": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-022-04132-8"}, {"db": "pmc", "key": "PMC9434518"}, {"db": "ClinicalTrials.gov", "key": "NCT02765191"}], "notes": [], "created": "2022-10-13T13:09:07.211Z", "modified": "2022-10-13T13:12:09.772Z"}, {"entity": "publication", "iuid": "cd676674860e43b297b2ffd3e77406b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd676674860e43b297b2ffd3e77406b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd676674860e43b297b2ffd3e77406b0"}}, "title": "When ethnographic work turns into distant screen visits: A note on flexible inflexibility during the COVID-19 pandemic.", "authors": [{"family": "Sandberg", "given": "Helena", "initials": "H"}, {"family": "Sundin", "given": "Ebba", "initials": "E", "orcid": "0000-0001-8712-7159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/55da76954579410d8b8c795429f03149.json"}}, {"family": "Sj\u00f6berg", "given": "Ulrika", "initials": "U"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Contemp Issues Early Child", "issn": "1463-9491", "issn-l": null, "volume": "23", "issue": "3", "pages": "361-365"}, "abstract": "This colloquium shares experiences from doing ethnographic fieldwork with young children and the challenges that followed due to the COVID-19 pandemic. The project DIGIKIDS Sweden has its focus on very young children (birth to three years) and their engagement with digital media technologies in their homes. The pandemic put the project on hold, but in the families where the fieldwork had already started, the authors decided to change the methods of data collection. Digital screen visits were introduced and, at first, this seemed to be flexible, and they adjusted to the new environment. At the same time, this flexibility also became an inflexible experience due to the use of technology.", "doi": "10.1177/14639491221107361", "pmid": "37520115", "labels": {"Funder: VR": null, "Category: Other": null, "Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC9194497"}, {"db": "pii", "key": "10.1177_14639491221107361"}], "notes": [], "created": "2023-10-04T12:12:41.646Z", "modified": "2023-10-04T13:32:54.390Z"}, {"entity": "publication", "iuid": "70ac7e22db0848d588ed605cd740756d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70ac7e22db0848d588ed605cd740756d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70ac7e22db0848d588ed605cd740756d"}}, "title": "The effect of different degrees of lockdown and self-identified gender on anxiety, depression and suicidality during the COVID-19 pandemic: Data from the international COMET-G study.", "authors": [{"family": "Fountoulakis", "given": "Konstantinos N", "initials": "KN"}, {"family": "Karakatsoulis", "given": "Grigorios N", "initials": "GN"}, {"family": "Abraham", "given": "Seri", "initials": "S"}, {"family": "Adorjan", "given": "Kristina", "initials": "K"}, {"family": "Ahmed", "given": "Helal Uddin", "initials": "HU"}, {"family": "Alarc\u00f3n", "given": "Renato D", "initials": "RD"}, {"family": "Arai", "given": "Kiyomi", "initials": "K"}, {"family": "Auwal", "given": "Sani Salihu", "initials": "SS"}, {"family": "Berk", "given": "Michael", "initials": "M"}, {"family": "Bjedov", "given": "Sarah", "initials": "S"}, {"family": "Bobes", "given": "Julio", "initials": "J"}, {"family": "Bobes-Bascaran", "given": "Teresa", "initials": "T"}, {"family": "Bourgin-Duchesnay", "given": "Julie", "initials": "J"}, {"family": "Bredicean", "given": "Cristina Ana", "initials": "CA"}, {"family": "Bukelskis", "given": "Laurynas", "initials": "L"}, {"family": "Burkadze", "given": "Akaki", "initials": "A"}, {"family": "Abud", "given": "Indira Indiana Cabrera", "initials": "IIC"}, {"family": "Castilla-Puentes", "given": "Ruby", "initials": "R"}, {"family": "Cetkovich", "given": "Marcelo", "initials": "M"}, {"family": "Colon-Rivera", "given": "Hector", "initials": "H"}, {"family": "Corral", "given": "Ricardo", "initials": "R"}, {"family": "Cortez-Vergara", "given": "Carla", "initials": "C"}, {"family": "Crepin", "given": "Piirika", "initials": "P"}, {"family": "De Berardis", "given": "Domenico", "initials": "D"}, {"family": "Delgado", "given": "Sergio Zamora", "initials": "SZ"}, {"family": "De Lucena", "given": "David", "initials": "D"}, {"family": "De Sousa", "given": "Avinash", "initials": "A"}, {"family": "Stefano", "given": "Ramona Di", "initials": "RD"}, {"family": "Dodd", "given": "Seetal", "initials": "S"}, {"family": "Elek", "given": "Livia Priyanka", "initials": "LP"}, {"family": "Elissa", "given": "Anna", "initials": "A"}, {"family": "Erdelyi-Hamza", "given": "Berta", "initials": "B"}, {"family": "Erzin", "given": "Gamze", "initials": "G"}, {"family": "Etchevers", "given": "Martin J", "initials": "MJ"}, {"family": "Falkai", "given": "Peter", "initials": "P"}, {"family": "Farcas", "given": "Adriana", "initials": "A"}, {"family": "Fedotov", "given": "Ilya", "initials": "I"}, {"family": "Filatova", "given": "Viktoriia", "initials": "V"}, {"family": "Fountoulakis", "given": "Nikolaos K", "initials": "NK"}, {"family": "Frankova", "given": "Iryna", "initials": "I"}, {"family": "Franza", "given": "Francesco", "initials": "F"}, {"family": "Frias", "given": "Pedro", "initials": "P"}, {"family": "Galako", "given": "Tatiana", "initials": "T"}, {"family": "Garay", "given": "Cristian J", "initials": "CJ"}, {"family": "Garcia-\u00c1lvarez", "given": "Leticia", "initials": "L"}, {"family": "Garc\u00eda-Portilla", "given": "Maria Paz", "initials": "MP"}, {"family": "Gonda", "given": "Xenia", "initials": "X"}, {"family": "Gondek", "given": "Tomasz M", "initials": "TM"}, {"family": "Gonz\u00e1lez", "given": "Daniela Morera", "initials": "DM"}, {"family": "Gould", "given": "Hilary", "initials": "H"}, {"family": "Grandinetti", "given": "Paolo", "initials": "P"}, {"family": "Grau", "given": "Arturo", "initials": "A"}, {"family": "Groudeva", "given": "Violeta", "initials": "V"}, {"family": "Hagin", "given": "Michal", "initials": "M"}, {"family": "Harada", "given": "Takayuki", "initials": "T"}, {"family": "Hasan", "given": "Tasdik M", "initials": "TM"}, {"family": "Hashim", "given": "Nurul Azreen", "initials": "NA"}, {"family": "Hilbig", "given": "Jan", "initials": "J"}, {"family": "Hossain", "given": "Sahadat", "initials": "S"}, {"family": "Iakimova", "given": "Rossitza", "initials": "R"}, {"family": "Ibrahim", "given": "Mona", "initials": "M"}, {"family": "Iftene", "given": "Felicia", "initials": "F"}, {"family": "Ignatenko", "given": "Yulia", "initials": "Y"}, {"family": "Irarrazaval", "given": "Matias", "initials": "M"}, {"family": "Ismail", "given": "Zaliha", "initials": "Z"}, {"family": "Ismayilova", "given": "Jamila", "initials": "J"}, {"family": "Jacobs", "given": "Asaf", "initials": "A"}, {"family": "Jakovljevi\u0107", "given": "Miro", "initials": "M"}, {"family": "Jak\u0161i\u0107", "given": "Nenad", "initials": "N"}, {"family": "Javed", "given": "Afzal", "initials": "A"}, {"family": "Kafali", "given": "Helin Yilmaz", "initials": "HY"}, {"family": "Karia", "given": "Sagar", "initials": "S"}, {"family": "Kazakova", "given": "Olga", "initials": "O"}, {"family": "Khalifa", "given": "Doaa", "initials": "D"}, {"family": "Khaustova", "given": "Olena", "initials": "O"}, {"family": "Koh", "given": "Steve", "initials": "S"}, {"family": "Kopishinskaia", "given": "Svetlana", "initials": "S"}, {"family": "Kosenko", "given": "Korneliia", "initials": "K"}, {"family": "Koupidis", "given": "Sotirios A", "initials": "SA"}, {"family": "Kovacs", "given": "Illes", "initials": "I"}, {"family": "Kulig", "given": "Barbara", "initials": "B"}, {"family": "Lalljee", "given": "Alisha", "initials": "A"}, {"family": "Liewig", "given": "Justine", "initials": "J"}, {"family": "Majid", "given": "Abdul", "initials": "A"}, {"family": "Malashonkova", "given": "Evgeniia", "initials": "E"}, {"family": "Malik", "given": "Khamelia", "initials": "K"}, {"family": "Malik", "given": "Najma Iqbal", "initials": "NI"}, {"family": "Mammadzada", "given": "Gulay", "initials": "G"}, {"family": "Mandalia", "given": "Bilvesh", "initials": "B"}, {"family": "Marazziti", "given": "Donatella", "initials": "D"}, {"family": "Mar\u010dinko", "given": "Darko", "initials": "D"}, {"family": "Martinez", "given": "Stephanie", "initials": "S"}, {"family": "Matiekus", "given": "Eimantas", "initials": "E"}, {"family": "Mejia", "given": "Gabriela", "initials": "G"}, {"family": "Memon", "given": "Roha Saeed", "initials": "RS"}, {"family": "Mart\u00ednez", "given": "Xarah Elenne Meza", "initials": "XEM"}, {"family": "Mickevi\u010di\u016bt\u0117", "given": "Dalia", "initials": "D"}, {"family": "Milev", "given": "Roumen", "initials": "R"}, {"family": "Mohammed", "given": "Muftau", "initials": "M"}, {"family": "Molina-L\u00f3pez", "given": "Alejandro", "initials": "A"}, {"family": "Morozov", "given": "Petr", "initials": "P"}, {"family": "Muhammad", "given": "Nuru Suleiman", "initials": "NS"}, {"family": "Musta\u010d", "given": "Filip", "initials": "F"}, {"family": "Naor", "given": "Mika S", "initials": "MS"}, {"family": "Nassieb", "given": "Amira", "initials": "A"}, {"family": "Navickas", "given": "Alvydas", "initials": "A"}, {"family": "Okasha", "given": "Tarek", "initials": "T"}, {"family": "Pandova", "given": "Milena", "initials": "M"}, {"family": "Panfil", "given": "Anca-Livia", "initials": "AL"}, {"family": "Panteleeva", "given": "Liliya", "initials": "L"}, {"family": "Papava", "given": "Ion", "initials": "I"}, {"family": "Patsali", "given": "Mikaella E", "initials": "ME"}, {"family": "Pavlichenko", "given": "Alexey", "initials": "A"}, {"family": "Pejuskovic", "given": "Bojana", "initials": "B"}, {"family": "Da Costa", "given": "Mariana Pinto", "initials": "MP"}, {"family": "Popkov", "given": "Mikhail", "initials": "M"}, {"family": "Popovic", "given": "Dina", "initials": "D"}, {"family": "Raduan", "given": "Nor Jannah Nasution", "initials": "NJN"}, {"family": "Ram\u00edrez", "given": "Francisca Vargas", "initials": "FV"}, {"family": "Rancans", "given": "Elmars", "initials": "E"}, {"family": "Razali", "given": "Salmi", "initials": "S"}, {"family": "Rebok", "given": "Federico", "initials": "F"}, {"family": "Rewekant", "given": "Anna", "initials": "A"}, {"family": "Flores", "given": "Elena Ninoska Reyes", "initials": "ENR"}, {"family": "Rivera-Encinas", "given": "Mar\u00eda Teresa", "initials": "MT"}, {"family": "Saiz", "given": "Pilar", "initials": "P"}, {"family": "de Carmona", "given": "Manuel S\u00e1nchez", "initials": "MS"}, {"family": "Mart\u00ednez", "given": "David Saucedo", "initials": "DS"}, {"family": "Saw", "given": "Jo Anne", "initials": "JA"}, {"family": "Saygili", "given": "G\u00f6rkem", "initials": "G"}, {"family": "Schneidereit", "given": "Patricia", "initials": "P"}, {"family": "Shah", "given": "Bhumika", "initials": "B"}, {"family": "Shirasaka", "given": "Tomohiro", "initials": "T"}, {"family": "Silagadze", "given": "Ketevan", "initials": "K"}, {"family": "Sitanggang", "given": "Satti", "initials": "S"}, {"family": "Skugarevsky", "given": "Oleg", "initials": "O"}, {"family": "Spikina", "given": "Anna", "initials": "A"}, {"family": "Mahalingappa", "given": "Sridevi Sira", "initials": "SS"}, {"family": "Stoyanova", "given": "Maria", "initials": "M"}, {"family": "Szczegielniak", "given": "Anna", "initials": "A"}, {"family": "Tamasan", "given": "Simona Claudia", "initials": "SC"}, {"family": "Tavormina", "given": "Giuseppe", "initials": "G"}, {"family": "Tavormina", "given": "Maurilio Giuseppe Maria", "initials": "MGM"}, {"family": "Theodorakis", "given": "Pavlos N", "initials": "PN"}, {"family": "Tohen", "given": "Mauricio", "initials": "M"}, {"family": "Tsapakis", "given": "Eva Maria", "initials": "EM"}, {"family": "Tukhvatullina", "given": "Dina", "initials": "D"}, {"family": "Ullah", "given": "Irfan", "initials": "I"}, {"family": "Vaidya", "given": "Ratnaraj", "initials": "R"}, {"family": "Vega-Dienstmaier", "given": "Johann M", "initials": "JM"}, {"family": "Vrublevska", "given": "Jelena", "initials": "J"}, {"family": "Vukovic", "given": "Olivera", "initials": "O"}, {"family": "Vysotska", "given": "Olga", "initials": "O"}, {"family": "Widiasih", "given": "Natalia", "initials": "N"}, {"family": "Yashikhina", "given": "Anna", "initials": "A"}, {"family": "Prezerakos", "given": "Panagiotis E", "initials": "PE"}, {"family": "Smirnova", "given": "Daria", "initials": "D"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "volume": "315", "pages": "114702", "issn-l": null}, "abstract": "During the COVID-19 pandemic various degrees of lockdown were applied by countries around the world. It is considered that such measures have an adverse effect on mental health but the relationship of measure intensity with the mental health effect has not been thoroughly studied. Here we report data from the larger COMET-G study pertaining to this question.\n\nDuring the COVID-19 pandemic, data were gathered with an online questionnaire from 55,589 participants from 40 countries (64.85% females aged 35.80 \u00b1 13.61; 34.05% males aged 34.90\u00b113.29 and 1.10% other aged 31.64\u00b113.15). Anxiety was measured with the STAI, depression with the CES-D and suicidality with the RASS. Distress and probable depression were identified with the use of a previously developed cut-off and algorithm respectively.\n\nIt included the calculation of Relative Risk (RR), Factorial ANOVA and Multiple backwards stepwise linear regression analysis RESULTS: Approximately two-thirds were currently living under significant restrictions due to lockdown. For both males and females the risk to develop clinical depression correlated significantly with each and every level of increasing lockdown degree (RR 1.72 and 1.90 respectively). The combined lockdown and psychiatric history increased RR to 6.88 The overall relationship of lockdown with severity of depression, though significant was small.\n\nThe current study is the first which reports an almost linear relationship between lockdown degree and effect in mental health. Our findings, support previous suggestions concerning the need for a proactive targeted intervention to protect mental health more specifically in vulnerable groups.", "doi": "10.1016/j.psychres.2022.114702", "pmid": "35839639", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(22)00298-0"}, {"db": "pmc", "key": "PMC9247180"}], "notes": [], "created": "2022-08-12T08:55:50.569Z", "modified": "2022-08-12T08:55:50.575Z"}, {"entity": "publication", "iuid": "9cc5dabbdf0a4825a47370d9e992c94b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9cc5dabbdf0a4825a47370d9e992c94b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9cc5dabbdf0a4825a47370d9e992c94b"}}, "title": "Suicide numbers during the first 9-15 months of the COVID-19 pandemic compared with pre-existing trends: An interrupted time series analysis in 33 countries.", "authors": [{"family": "Pirkis", "given": "Jane", "initials": "J"}, {"family": "Gunnell", "given": "David", "initials": "D"}, {"family": "Shin", "given": "Sangsoo", "initials": "S"}, {"family": "Del Pozo-Banos", "given": "Marcos", "initials": "M"}, {"family": "Arya", "given": "Vikas", "initials": "V"}, {"family": "Aguilar", "given": "Pablo Analuisa", "initials": "PA"}, {"family": "Appleby", "given": "Louis", "initials": "L"}, {"family": "Arafat", "given": "S M Yasir", "initials": "SMY"}, {"family": "Arensman", "given": "Ella", "initials": "E"}, {"family": "Ayuso-Mateos", "given": "Jose Luis", "initials": "JL"}, {"family": "Balhara", "given": "Yatan Pal Singh", "initials": "YPS"}, {"family": "Bantjes", "given": "Jason", "initials": "J"}, {"family": "Baran", "given": "Anna", "initials": "A"}, {"family": "Behera", "given": "Chittaranjan", "initials": "C"}, {"family": "Bertolote", "given": "Jose", "initials": "J"}, {"family": "Borges", "given": "Guilherme", "initials": "G"}, {"family": "Bray", "given": "Michael", "initials": "M"}, {"family": "Bre\u010di\u0107", "given": "Petrana", "initials": "P"}, {"family": "Caine", "given": "Eric", "initials": "E"}, {"family": "Calati", "given": "Raffaella", "initials": "R"}, {"family": "Carli", "given": "Vladimir", "initials": "V"}, {"family": "Castelpietra", "given": "Giulio", "initials": "G"}, {"family": "Chan", "given": "Lai Fong", "initials": "LF"}, {"family": "Chang", "given": "Shu-Sen", "initials": "SS"}, {"family": "Colchester", "given": "David", "initials": "D"}, {"family": "Coss-Guzm\u00e1n", "given": "Maria", "initials": "M"}, {"family": "Crompton", "given": "David", "initials": "D"}, {"family": "\u0106urkovi\u0107", "given": "Marko", "initials": "M"}, {"family": "Dandona", "given": "Rakhi", "initials": "R"}, {"family": "De Jaegere", "given": "Eva", "initials": "E"}, {"family": "De Leo", "given": "Diego", "initials": "D"}, {"family": "Deisenhammer", "given": "Eberhard A", "initials": "EA"}, {"family": "Dwyer", "given": "Jeremy", "initials": "J"}, {"family": "Erlangsen", "given": "Annette", "initials": "A"}, {"family": "Faust", "given": "Jeremy S", "initials": "JS"}, {"family": "Fornaro", "given": "Michele", "initials": "M"}, {"family": "Fortune", "given": "Sarah", "initials": "S"}, {"family": "Garrett", "given": "Andrew", "initials": "A"}, {"family": "Gentile", "given": "Guendalina", "initials": "G"}, {"family": "Gerstner", "given": "Rebekka", "initials": "R"}, {"family": "Gilissen", "given": "Renske", "initials": "R"}, {"family": "Gould", "given": "Madelyn", "initials": "M"}, {"family": "Gupta", "given": "Sudhir Kumar", "initials": "SK"}, {"family": "Hawton", "given": "Keith", "initials": "K"}, {"family": "Holz", "given": "Franziska", "initials": "F"}, {"family": "Kamenshchikov", "given": "Iurii", "initials": "I"}, {"family": "Kapur", "given": "Navneet", "initials": "N"}, {"family": "Kasal", "given": "Alexandr", "initials": "A"}, {"family": "Khan", "given": "Murad", "initials": "M"}, {"family": "Kirtley", "given": "Olivia J", "initials": "OJ"}, {"family": "Knipe", "given": "Duleeka", "initials": "D"}, {"family": "K\u00f5lves", "given": "Kairi", "initials": "K"}, {"family": "K\u00f6lzer", "given": "Sarah C", "initials": "SC"}, {"family": "Krivda", "given": "Hryhorii", "initials": "H"}, {"family": "Leske", "given": "Stuart", "initials": "S"}, {"family": "Madeddu", "given": "Fabio", "initials": "F"}, {"family": "Marshall", "given": "Andrew", "initials": "A"}, {"family": "Memon", "given": "Anjum", "initials": "A"}, {"family": "Mittendorfer-Rutz", "given": "Ellenor", "initials": "E"}, {"family": "Nestadt", "given": "Paul", "initials": "P"}, {"family": "Neznanov", "given": "Nikolay", "initials": "N"}, {"family": "Niederkrotenthaler", "given": "Thomas", "initials": "T"}, {"family": "Nielsen", "given": "Emma", "initials": "E"}, {"family": "Nordentoft", "given": "Merete", "initials": "M"}, {"family": "Oberlerchner", "given": "Herwig", "initials": "H"}, {"family": "O'Connor", "given": "Rory C", "initials": "RC"}, {"family": "Papsdorf", "given": "Rainer", "initials": "R"}, {"family": "Partonen", "given": "Timo", "initials": "T"}, {"family": "Phillips", "given": "Michael R", "initials": "MR"}, {"family": "Platt", "given": "Steve", "initials": "S"}, {"family": "Portzky", "given": "Gwendolyn", "initials": "G"}, {"family": "Psota", "given": "Georg", "initials": "G"}, {"family": "Qin", "given": "Ping", "initials": "P"}, {"family": "Radeloff", "given": "Daniel", "initials": "D"}, {"family": "Reif", "given": "Andreas", "initials": "A"}, {"family": "Reif-Leonhard", "given": "Christine", "initials": "C"}, {"family": "Rezaeian", "given": "Mohsen", "initials": "M"}, {"family": "Rom\u00e1n-V\u00e1zquez", "given": "Nayda", "initials": "N"}, {"family": "Roskar", "given": "Saska", "initials": "S"}, {"family": "Rozanov", "given": "Vsevolod", "initials": "V"}, {"family": "Sara", "given": "Grant", "initials": "G"}, {"family": "Scavacini", "given": "Karen", "initials": "K"}, {"family": "Schneider", "given": "Barbara", "initials": "B"}, {"family": "Semenova", "given": "Natalia", "initials": "N"}, {"family": "Sinyor", "given": "Mark", "initials": "M"}, {"family": "Tambuzzi", "given": "Stefano", "initials": "S"}, {"family": "Townsend", "given": "Ellen", "initials": "E"}, {"family": "Ueda", "given": "Michiko", "initials": "M"}, {"family": "Wasserman", "given": "Danuta", "initials": "D"}, {"family": "Webb", "given": "Roger T", "initials": "RT"}, {"family": "Winkler", "given": "Petr", "initials": "P"}, {"family": "Yip", "given": "Paul S F", "initials": "PSF"}, {"family": "Zalsman", "given": "Gil", "initials": "G"}, {"family": "Zoja", "given": "Riccardo", "initials": "R"}, {"family": "John", "given": "Ann", "initials": "A"}, {"family": "Spittal", "given": "Matthew J", "initials": "MJ"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": "51", "pages": "101573", "issn-l": null}, "abstract": "Predicted increases in suicide were not generally observed in the early months of the COVID-19 pandemic. However, the picture may be changing and patterns might vary across demographic groups. We aimed to provide a timely, granular picture of the pandemic's impact on suicides globally.\n\nWe identified suicide data from official public-sector sources for countries/areas-within-countries, searching websites and academic literature and contacting data custodians and authors as necessary. We sent our first data request on 22nd June 2021 and stopped collecting data on 31st October 2021. We used interrupted time series (ITS) analyses to model the association between the pandemic's emergence and total suicides and suicides by sex-, age- and sex-by-age in each country/area-within-country. We compared the observed and expected numbers of suicides in the pandemic's first nine and first 10-15 months and used meta-regression to explore sources of variation.\n\nWe sourced data from 33 countries (24 high-income, six upper-middle-income, three lower-middle-income; 25 with whole-country data, 12 with data for area(s)-within-the-country, four with both). There was no evidence of greater-than-expected numbers of suicides in the majority of countries/areas-within-countries in any analysis; more commonly, there was evidence of lower-than-expected numbers. Certain sex, age and sex-by-age groups stood out as potentially concerning, but these were not consistent across countries/areas-within-countries. In the meta-regression, different patterns were not explained by countries' COVID-19 mortality rate, stringency of public health response, economic support level, or presence of a national suicide prevention strategy. Nor were they explained by countries' income level, although the meta-regression only included data from high-income and upper-middle-income countries, and there were suggestions from the ITS analyses that lower-middle-income countries fared less well.\n\nAlthough there are some countries/areas-within-countries where overall suicide numbers and numbers for certain sex- and age-based groups are greater-than-expected, these countries/areas-within-countries are in the minority. Any upward movement in suicide numbers in any place or group is concerning, and we need to remain alert to and respond to changes as the pandemic and its mental health and economic consequences continue.\n\nNone.", "doi": "10.1016/j.eclinm.2022.101573", "pmid": "35935344", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(22)00303-0"}, {"db": "pmc", "key": "PMC9344880"}], "notes": [], "created": "2022-08-11T11:54:15.512Z", "modified": "2022-08-11T11:54:31.471Z"}, {"entity": "publication", "iuid": "e7bc0812ea3a459ca640b1d9f5195864", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e7bc0812ea3a459ca640b1d9f5195864.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e7bc0812ea3a459ca640b1d9f5195864"}}, "title": "Observed protection against SARS-CoV-2 reinfection following a primary infection: A Danish cohort study among unvaccinated using two years of nationwide PCR-test data.", "authors": [{"family": "Michlmayr", "given": "Daniela", "initials": "D"}, {"family": "Hansen", "given": "Christian Holm", "initials": "CH"}, {"family": "Gubbels", "given": "Sophie Madeleine", "initials": "SM"}, {"family": "Valentiner-Branth", "given": "Palle", "initials": "P"}, {"family": "Bager", "given": "Peter", "initials": "P"}, {"family": "Obel", "given": "Niels", "initials": "N"}, {"family": "Drewes", "given": "Birgitte", "initials": "B"}, {"family": "M\u00f8ller", "given": "Camilla Holten", "initials": "CH"}, {"family": "M\u00f8ller", "given": "Frederik Trier", "initials": "FT"}, {"family": "Legarth", "given": "Rebecca", "initials": "R"}, {"family": "M\u00f8lbak", "given": "K\u00e5re", "initials": "K"}, {"family": "Ethelberg", "given": "Steen", "initials": "S"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "20", "pages": "100452", "issn-l": null}, "abstract": "The level of protection after a SARS-CoV-2 infection against reinfection and COVID-19 disease remains important with much of the world still unvaccinated.\n\nAnalysing nationwide, individually referable, Danish register data including RT-PCR-test results, we conducted a cohort study using Cox regression to compare SARS-CoV-2 infection rates before and after a primary infection among still unvaccinated individuals, adjusting for sex, age, comorbidity and residency region. Estimates of protection against infection were calculated as 1 minus the hazard ratio. Estimates of protection against symptomatic infections and infections leading to hospitalisation were also calculated. The prevalence of infections classified as symptomatic or asymptomatic was compared for primary infections and reinfections. The study also assessed protection against each of the main viral variants after a primary infection with an earlier variant by restricting follow-up time to distinct, mutually exclusive periods during which each variant dominated.\n\nUntil 1 July 2021 the estimated protection against reinfection was 83.4% (95%CI: 82.2-84.6%); but lower for the 65+ year-olds (72.2%; 95%CI: 53.2-81.0%). Moderately higher estimates were found for protection against symptomatic disease, 88.3% overall (95%CI: 85.9-90.3%). First-time cases who reported no symptoms were more likely to experience a reinfection (odds ratio: 1.48; 95%CI: 1.35-1.62). By autumn 2021, when infections were almost exclusively caused by the Delta variant, the estimated protection following a recent first infection was 91.3% (95%CI: 89.7-92.7%) compared to 71.4% (95%CI: 66.9-75.3%) after a first infection over a year earlier. With Omicron, a first infection with an earlier variant in the past 3-6 months gave an estimated 51.0% (95%CI: 50.1-52.0%) protection, whereas a first infection longer than 12 months earlier provided only 19.0% (95%CI: 17.2-20.5%) protection. Protection by an earlier variant-infection against hospitalisation due to a new infection was estimated at: 86.6% (95%CI: 46.3-96.7%) for Alpha, 97.2% (95%CI: 89.0-99.3%) for Delta, and 69.8% (95%CI: 51.5-81.2%) for the Omicron variant.\n\nSARS-CoV-2 infection offered a high level of sustained protection against reinfection, comparable with that offered by vaccines, but decreased with the introduction of new main virus variants; dramatically so when Omicron appeared. Protection was lower among the elderly but appeared more pronounced following symptomatic compared to asymptomatic infections. The level of estimated protection against serious disease was somewhat higher than that against infection and possibly longer lasting. Decreases in protection against reinfection, seemed primarily to be driven by viral evolution.\n\nNone.", "doi": "10.1016/j.lanepe.2022.100452", "pmid": "35791335", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(22)00146-6"}, {"db": "pmc", "key": "PMC9245510"}], "notes": [], "created": "2022-08-17T13:07:20.171Z", "modified": "2022-08-17T13:07:20.177Z"}, {"entity": "publication", "iuid": "8794c597e5324ef1ab64bcd361a60c3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8794c597e5324ef1ab64bcd361a60c3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8794c597e5324ef1ab64bcd361a60c3d"}}, "title": "Initiation of antihypertensive drugs to patients with confirmed COVID-19-A population-based cohort study in Sweden.", "authors": [{"family": "Mousa", "given": "Salar Issa", "initials": "SI"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Hajiebrahimi", "given": "Mohammadhossein", "initials": "M", "orcid": "0000-0001-8118-4988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8338602bdf4d40ffb25713e73b1fc719.json"}}, {"family": "Bertilsson", "given": "Rebecka", "initials": "R"}, {"family": "N\u00e5tman", "given": "Jonatan", "initials": "J"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0003-0531-2516", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4911f8524d634e928a77f67c40e1610d.json"}}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Basic Clin Pharmacol Toxicol", "issn": "1742-7843", "volume": "131", "issue": "3", "pages": "196-204", "issn-l": null}, "abstract": "Hypertension is an important risk factor for severe outcomes in patients with COVID-19, and antihypertensive drugs may have a protective effect. However, the pandemic may have negatively impacted health care services for chronic diseases. The aim of this study was to assess initiations of antihypertensive medicines in patients infected by COVID-19.\n\nA cohort study including all Swedish residents 20-80 years old with a COVID-19 positive test compared with an unexposed group without COVID-19 matched for age, sex, and index date (date of confirmed COVID-19). Data were collected within SCIFI-PEARL, a study including linked data on COVID tests, hospital diagnoses, dispensed prescriptions, and socioeconomic data from Swedish national registers. Initiations of different antihypertensive drugs were studied from March 2020 until October 2020. Associations between COVID-19 and initiation of antihypertensives were assessed by a multivariable Cox proportional hazards model.\n\nA total of 224 582 patients (exposed and unexposed) were included. After adjusting for cardiovascular comorbidities and education level, ACEi was the most commonly initiated antihypertensive agent to patients with COVID-19. Hazard ratio and 95% confidence interval for initiation of drug therapy was 1.83 [1.53-2.19] for ACEi, followed by beta-blockers 1.74 [1.55-1.95], calcium channel blockers 1.61 [1.41-1.83], angiotensin receptor blockers 1.61 [1.40-1.86], and diuretics 1.53 [1.32-1.77].\n\nAll antihypertensive medicines were initiated more frequently in COVID-19 patients. This can either be associated with hypertension caused by the COVID-19 infection, more frequent diagnosis of hypertension among people with COVID-19 since they consult health care, or residual confounding factors not adjusted for in the study.", "doi": "10.1111/bcpt.13766", "pmid": "35726121", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9349802"}], "notes": [], "created": "2022-08-17T13:05:13.777Z", "modified": "2022-08-17T13:05:13.888Z"}, {"entity": "publication", "iuid": "3ac144a28cbb44b5bf6a5d2d018dd811", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ac144a28cbb44b5bf6a5d2d018dd811.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ac144a28cbb44b5bf6a5d2d018dd811"}}, "title": "Increased antidepressant use during the COVID-19 pandemic: Findings from the Friuli Venezia Giulia region, Italy, 2015-2020.", "authors": [{"family": "Pazzagli", "given": "Laura", "initials": "L"}, {"family": "Reutfors", "given": "Johan", "initials": "J"}, {"family": "Lucian", "given": "Ejlli", "initials": "E"}, {"family": "Zerial", "given": "Giovanna", "initials": "G"}, {"family": "Perulli", "given": "Alfredo", "initials": "A"}, {"family": "Castelpietra", "given": "Giulio", "initials": "G"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "volume": "315", "pages": "114704", "issn-l": null}, "abstract": "Few studies investigated the impact of the pandemic on antidepressant (AD) use.\n\nThe Social and Health Information System of Friuli Venezia Giulia region, Italy, provided data on AD use. Sex, age, AD class and month used the amount of AD prescriptions, measured by defined daily doses (DDD) per 1000 inhabitants per day, to compare AD use in 2020 with the period 2015-2019. A linear trend model predicted AD use for 2020, based on years 2015-2019.\n\nAD use was on average 20% higher in each month of 2020 when compared with the same month for the period 2015-2019, with an increase of more than 30% in the first four and in the last two months of 2020. The observed AD use in 2020 was higher than predicted, particularly in men, and in the 30-59 years age group.\n\nDescriptive study of AD use without analysis of data at the individual level. No information on psychiatric diagnoses of AD users.\n\nAD use was higher in the first year of the COVID-19 pandemic. Further research is warranted to understand if this may be related to a rise in mental disorders in the general population during the COVID-19 pandemic.", "doi": "10.1016/j.psychres.2022.114704", "pmid": "35830755", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(22)00300-6"}, {"db": "pmc", "key": "PMC9245333"}], "notes": [], "created": "2022-08-17T10:34:16.218Z", "modified": "2022-08-17T10:35:06.031Z"}, {"entity": "publication", "iuid": "7810c03718d54d36b6ca5230a6a64161", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7810c03718d54d36b6ca5230a6a64161.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7810c03718d54d36b6ca5230a6a64161"}}, "title": "Impaired immunity and high attack rates caused by SARS-CoV-2 variants among vaccinated long-term care facility residents.", "authors": [{"family": "Obach", "given": "Doroth\u00e9e", "initials": "D"}, {"family": "Solastie", "given": "Anna", "initials": "A", "orcid": "0000-0002-3848-2768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/95c7cbcd3ad843b4b74b9650e1d78f4a.json"}}, {"family": "Liedes", "given": "Oona", "initials": "O"}, {"family": "Vara", "given": "Saimi", "initials": "S"}, {"family": "Krzy\u017cewska-Dudek", "given": "Eva", "initials": "E", "orcid": "0000-0002-5581-1690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b24b973fe1674251af971a0112680320.json"}}, {"family": "Brinkmann", "given": "Luise", "initials": "L"}, {"family": "Haveri", "given": "Anu", "initials": "A", "orcid": "0000-0003-4620-7536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad75e87cc8d34f5cb3849a646d0e5e99.json"}}, {"family": "Hammer", "given": "Charlotte C", "initials": "CC"}, {"family": "Dub", "given": "Timoth\u00e9e", "initials": "T"}, {"family": "Meri", "given": "Seppo", "initials": "S", "orcid": "0000-0001-9142-501X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51708db39bbc477e9e94d09f99bab271.json"}}, {"family": "Freitag", "given": "Tobias L", "initials": "TL"}, {"family": "Lyytik\u00e4inen", "given": "Outi", "initials": "O"}, {"family": "Melin", "given": "Merit", "initials": "M"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Immun Inflamm Dis", "issn": "2050-4527", "volume": "10", "issue": "9", "pages": "e679", "issn-l": null}, "abstract": "Long-term care facilities (LTCF) residents are at high risk for severe coronavirus disease 2019 (COVID-19), and therefore, COVID-19 vaccinations were prioritized for residents and personnel in Finland at the beginning of 2021.\n\nWe investigated COVID-19 outbreaks in two LTCFs, where residents were once or twice vaccinated. After the outbreaks we measured immunoglobulin G (IgG) antibodies to severe acute respiratory syndrome coronavirus 2 spike glycoprotein, neutralizing antibody (NAb) titers, and cell-mediated immunity markers from residents and healthcare workers (HCWs).\n\nIn LTFC-1, the outbreak was caused by an Alpha variant (B.1.1.7) and the attack rate (AR) among once vaccinated residents was 23%. In LTCF-2 the outbreak was caused by a Beta variant (B.1.351). Its AR was 47% although all residents had received their second dose 1 month before the outbreak. We observed that vaccination had induced lower IgG concentrations, NAb titers and cell-mediated immune responses in residents compared to HCWs. Only 1/8 residents had NAb to the Beta variant after two vaccine doses.\n\nThe vaccinated elderly remain susceptible to breakthrough infections caused by Alpha and Beta variants. The weaker vaccine response in the elderly needs to be addressed in vaccination protocols, while new variants capable of evading vaccine-induced immunity continue to emerge.", "doi": "10.1002/iid3.679", "pmid": "36039644", "labels": {"Category: Vaccines": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9382858"}], "notes": [], "created": "2022-10-07T12:48:28.482Z", "modified": "2022-10-07T12:48:28.632Z"}, {"entity": "publication", "iuid": "8dbd78fd144c4e50a77459317b2f5262", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8dbd78fd144c4e50a77459317b2f5262.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8dbd78fd144c4e50a77459317b2f5262"}}, "title": "Immunomodulation by intravenous omega-3 fatty acid treatment in older subjects hospitalized for COVID-19: A single-blind randomized controlled trial.", "authors": [{"family": "Arnardottir", "given": "Hildur", "initials": "H", "orcid": "0000-0002-5163-3946", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/942fb973fd3e4a1e8f85c10e6fff4423.json"}}, {"family": "Pawelzik", "given": "Sven-Christian", "initials": "SC", "orcid": "0000-0001-8704-6607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5249b23453a347a883217f7c90cfeb00.json"}}, {"family": "Sarajlic", "given": "Philip", "initials": "P", "orcid": "0000-0002-8690-7994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a623ec0669142d889964c3a5697d109.json"}}, {"family": "Quaranta", "given": "Alessandro", "initials": "A", "orcid": "0000-0002-3167-3772", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7821ced4ee8842d69ae9081bde5278d7.json"}}, {"family": "Kolmert", "given": "Johan", "initials": "J"}, {"family": "Religa", "given": "Dorota", "initials": "D", "orcid": "0000-0003-4583-4570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e2c968ecffa4c638126d6d8d4a0dbd9.json"}}, {"family": "Wheelock", "given": "Craig E", "initials": "CE", "orcid": "0000-0002-8113-0653", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7fe4d1cc7804c6d9d1506dc8db516ea.json"}}, {"family": "B\u00e4ck", "given": "Magnus", "initials": "M", "orcid": "0000-0003-0853-5141", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a3a2ec52b7044719f83c4863b5cdb7b.json"}}], "type": "letter", "published": "2022-09-00", "journal": {"title": "Clin Transl Med", "issn": "2001-1326", "volume": "12", "issue": "9", "pages": "e895", "issn-l": null}, "abstract": null, "doi": "10.1002/ctm2.895", "pmid": "36121173", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9484265"}], "notes": [], "created": "2022-10-13T13:36:26.009Z", "modified": "2023-06-19T15:19:23.363Z"}, {"entity": "publication", "iuid": "884a9a950c48485eafe0e7de1980add6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/884a9a950c48485eafe0e7de1980add6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/884a9a950c48485eafe0e7de1980add6"}}, "title": "Geographical distribution of cystic fibrosis carriers as population genetic determinant of COVID-19 spread and fatality in 37 countries.", "authors": [{"family": "Gabbi", "given": "Chiara", "initials": "C"}, {"family": "Renieri", "given": "Alessandra", "initials": "A"}, {"family": "Strandvik", "given": "Birgitta", "initials": "B"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "J Infect", "issn": "1532-2742", "volume": "85", "issue": "3", "pages": "318-321", "issn-l": "0163-4453"}, "abstract": "COVID-19 has shown a relevant heterogeneity in spread and fatality among countries together with a significant variability in its clinical presentation, indicating that host genetic factors may influence COVID-19 pathogenicity. Indeed, subjects carrying single pathogenic variants of the Cystic Fibrosis (CF) Transmembrane Conductance Regulator (CFTR) gene - i.e. CF carriers - are more susceptible to respiratory tract infections and are more likely to undergo severe COVID-19 with higher risk of 14-day mortality. Given that CF carrier prevalence varies among ethnicities and nations, an ecological study in 37 countries was conducted, in order to determine to what extent the diverse CF carrier geographical distribution may have affected COVID-19 spread and fatality during the first pandemic wave. The CF prevalence in countries, as indicator of the geographical distribution of CF carriers, significantly correlated in a direct manner with both COVID-19 prevalence and its Case Fatality Rate (CFR). In a regression study weighted for the number of tests performed, COVID-19 prevalence positively correlated with CF prevalence, while CFR correlated with population percentage older than 65-year, cancer and CF prevalence. Multivariate regression model also confirmed COVID-19 CFR to be associated with CF prevalence, after adjusting for elderly, cancer prevalence, and weighting for the number of tests performed. This study suggests a putative contribution of population genetics of CFTR in understanding the spatial distribution of COVID-19 spread and fatality.", "doi": "10.1016/j.jinf.2022.06.006", "pmid": "35700866", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0163-4453(22)00359-0"}, {"db": "pmc", "key": "PMC9188282"}], "notes": [], "created": "2022-06-20T18:15:47.594Z", "modified": "2022-08-17T13:01:42.707Z"}, {"entity": "publication", "iuid": "3806cd89b54a4248bc55b0da0ad24174", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3806cd89b54a4248bc55b0da0ad24174.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3806cd89b54a4248bc55b0da0ad24174"}}, "title": "Design and Analysis of Studies Based on Hierarchical Composite Endpoints: Insights from the DARE-19 Trial.", "authors": [{"family": "Gasparyan", "given": "Samvel B", "initials": "SB", "orcid": "0000-0002-4797-2208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fe0aea6b8d940a4aa97beac64753452.json"}}, {"family": "Buenconsejo", "given": "Joan", "initials": "J", "orcid": "0000-0003-4514-2208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90cef2fa64d0486681f64332929d92cf.json"}}, {"family": "Kowalewski", "given": "Elaine K", "initials": "EK", "orcid": "0000-0002-7915-877X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0c063ae9205470c9803add8044303bc.json"}}, {"family": "Oscarsson", "given": "Jan", "initials": "J", "orcid": "0000-0002-4573-517X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40a4f5060bd147c08b93f49e441ed37c.json"}}, {"family": "Bengtsson", "given": "Olof F", "initials": "OF", "orcid": "0000-0003-1315-8176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ae11bf6102548649d358e95a3f44766.json"}}, {"family": "Esterline", "given": "Russell", "initials": "R"}, {"family": "Koch", "given": "Gary G", "initials": "GG"}, {"family": "Berwanger", "given": "Otavio", "initials": "O"}, {"family": "Kosiborod", "given": "Mikhail N", "initials": "MN"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Ther Innov Regul Sci", "issn": "2168-4804", "volume": "56", "issue": "5", "pages": "785-794", "issn-l": null}, "abstract": "DARE-19 (NCT04350593) was a randomized trial studying the effects of dapagliflozin, an SGLT2 inhibitor, in hospitalized patients with COVID-19 pneumonia and cardiometabolic risk factors. The conduct of DARE-19 offered the opportunity to define an innovative and clinically meaningful endpoint in a new disease that would best reflect the known profile of dapagliflozin, accompanied by the statistical challenges of analysis and interpretation of such a novel endpoint.\n\nHierarchical composite endpoints (HCEs) are based on clinical outcomes which, unlike traditional composite endpoints incorporate ranking of components according to clinical importance. Design of an HCE requires the clinical considerations specific to the therapeutic area under study and the mechanism of action of the investigational treatment. Statistical aspects for the clinical endpoints include the proper definition of the estimand as suggested by ICH E9(R1) for the precise specification of the treatment effect measured by an HCE.\n\nWe describe the estimand of the DARE-19 trial, where an HCE was constructed to capture the treatment effect of dapagliflozin in hospitalized patients with COVID-19, and was analyzed using a win odds. Practical aspects of designing new studies based on an HCE are described. These include sample size, power, and minimal detectable effect calculations for an HCE based on the win odds analysis, as well as handling of missing data and the clinical interpretability of the win odds in relation to the estimand.\n\nHCEs are flexible endpoints that can be adapted for use in different therapeutic areas, with win odds as the analysis method. DARE-19 is an example of a COVID-19 trial with an HCE as one of the primary endpoints for estimating a clinically interpretable treatment effect in the COVID-19 setting.", "doi": "10.1007/s43441-022-00420-1", "pmid": "35699910", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s43441-022-00420-1"}, {"db": "pmc", "key": "PMC9196151"}], "notes": [], "created": "2022-06-20T18:16:07.446Z", "modified": "2022-08-17T13:02:09.052Z"}, {"entity": "publication", "iuid": "8101495174ac4c04b2cfde72073ef8fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8101495174ac4c04b2cfde72073ef8fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8101495174ac4c04b2cfde72073ef8fa"}}, "title": "COVID-19 clinical outcomes and DMT of MS patients and population-based controls.", "authors": [{"family": "Longinetti", "given": "Elisa", "initials": "E", "orcid": "0000-0002-4789-7172", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c376d8f47e6b4624861918e0f33abb6f.json"}}, {"family": "Bower", "given": "Hannah", "initials": "H"}, {"family": "McKay", "given": "Kyla A", "initials": "KA", "orcid": "0000-0002-9081-1522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8049ba5c52eb42c7bb866f5eee749173.json"}}, {"family": "Englund", "given": "Simon", "initials": "S", "orcid": "0000-0002-1042-4400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f87dfdb3db6f49d385f5266fa53e6262.json"}}, {"family": "Burman", "given": "Joachim", "initials": "J"}, {"family": "Fink", "given": "Katharina", "initials": "K"}, {"family": "Fogdell-Hahn", "given": "Anna", "initials": "A"}, {"family": "Gunnarsson", "given": "Martin", "initials": "M"}, {"family": "Hillert", "given": "Jan", "initials": "J"}, {"family": "Langer-Gould", "given": "Annette", "initials": "A", "orcid": "0000-0001-6891-7147", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fae9d189a7444ecc91c521031c9c1f9b.json"}}, {"family": "Lycke", "given": "Jan", "initials": "J"}, {"family": "Nilsson", "given": "Petra", "initials": "P"}, {"family": "Salzer", "given": "Jonatan", "initials": "J"}, {"family": "Svenningsson", "given": "Anders", "initials": "A"}, {"family": "Mellerg\u00e5rd", "given": "Johan", "initials": "J"}, {"family": "Olsson", "given": "Tomas", "initials": "T"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Frisell", "given": "Thomas", "initials": "T", "orcid": "0000-0002-5735-9626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e9d6be8c47b4d6eb80bd3d57a63172e.json"}}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Ann Clin Transl Neurol", "issn": "2328-9503", "volume": "9", "issue": "9", "pages": "1449-1458", "issn-l": "2328-9503"}, "abstract": "To estimate risks for all-cause mortality and for severe COVID-19 in multiple sclerosis patients and across relapsing-remitting multiple sclerosis patients exposed to disease-modifying therapies.\n\nWe conducted a Swedish nationwide population-based multi-register linkage cohort study and followed all multiple sclerosis patients (n = 17,692 in March 2020), individually age-, sex-, and region-matched to five population-based controls (n = 86,176 in March 2020) during March 2020-June 2021. We compared annual all-cause mortality within and across cohorts, and assessed incidence rates and relative risks for hospitalization, intensive care admission, and death due to COVID-19 in relation to disease-modifying therapy use, using Cox regression.\n\nAbsolute all-cause mortality among multiple sclerosis patients was higher from March to December 2020 than in previous years, but relative risks versus the population-based controls were similar to preceding years. Incidence rates of hospitalization, intensive care admission, and death due to COVID-19 remained in line with those for all-cause hospitalization, intensive care admission, and mortality. Among relapsing-remitting patients on rituximab, trends for differences in risk of hospitalization due to COVID-19 remained in the demographics-, socioeconomic status-, comorbidity-, and multiple sclerosis severity-adjusted model.\n\nRisks of severe COVID-19-related outcomes were increased among multiple sclerosis patients as a whole compared to population controls, but risk increases were also seen for non-COVID-19 hospitalization, intensive care admission, and mortality, and did not significantly differ during the pandemic compared to pre-pandemic years. The risk conveyed by disease-modifying therapies was smaller than previously assumed, likely as a consequence of the possibility to better control for confounders.", "doi": "10.1002/acn3.51646", "pmid": "35993445", "labels": {"Category: Biochemistry": null, "Research Area: Vaccine": null, "Funder: VR": null, "Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:54:21.518Z", "modified": "2022-09-12T18:54:33.463Z"}, {"entity": "publication", "iuid": "54071614f63543689180c5efe559a5f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54071614f63543689180c5efe559a5f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54071614f63543689180c5efe559a5f1"}}, "title": "Age-specific associations between underlying health conditions and hospitalisation, death and in-hospital death among confirmed COVID-19 cases: a multi-country study based on surveillance data, June to December 2020.", "authors": [{"family": "Funk", "given": "Tjede", "initials": "T"}, {"family": "Innocenti", "given": "Francesco", "initials": "F"}, {"family": "Gomes Dias", "given": "Joana", "initials": "J"}, {"family": "Nerlander", "given": "Lina", "initials": "L"}, {"family": "Melillo", "given": "Tanya", "initials": "T"}, {"family": "Gauci", "given": "Charmaine", "initials": "C"}, {"family": "Melillo", "given": "Jackie M", "initials": "JM"}, {"family": "Lenz", "given": "Patrik", "initials": "P"}, {"family": "Sebestova", "given": "Helena", "initials": "H"}, {"family": "Slezak", "given": "Pavel", "initials": "P"}, {"family": "Vlckova", "given": "Iva", "initials": "I"}, {"family": "Berild", "given": "Jacob Dag", "initials": "JD"}, {"family": "Mauroy", "given": "Camilla", "initials": "C"}, {"family": "Sepp\u00e4l\u00e4", "given": "Elina", "initials": "E"}, {"family": "T\u00f8nnessen", "given": "Ragnhild", "initials": "R"}, {"family": "Vergison", "given": "Anne", "initials": "A"}, {"family": "Mossong", "given": "Jo\u00ebl", "initials": "J"}, {"family": "Masi", "given": "Silvana", "initials": "S"}, {"family": "Huiart", "given": "Laetitia", "initials": "L"}, {"family": "Cullen", "given": "Gillian", "initials": "G"}, {"family": "Murphy", "given": "Niamh", "initials": "N"}, {"family": "O'Connor", "given": "Lois", "initials": "L"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}, {"family": "Mook", "given": "Piers", "initials": "P"}, {"family": "Pebody", "given": "Richard G", "initials": "RG"}, {"family": "Bundle", "given": "Nick", "initials": "N"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "27", "issue": "35", "issn-l": null}, "abstract": "BackgroundUnderlying conditions are risk factors for severe COVID-19 outcomes but evidence is limited about how risks differ with age.AimWe sought to estimate age-specific associations between underlying conditions and hospitalisation, death and in-hospital death among COVID-19 cases.MethodsWe analysed case-based COVID-19 data submitted to The European Surveillance System between 2 June and 13 December 2020 by nine European countries. Eleven underlying conditions among cases with only one condition and the number of underlying conditions among multimorbid cases were used as exposures. Adjusted odds ratios (aOR) were estimated using 39 different age-adjusted and age-interaction multivariable logistic regression models, with marginal means from the latter used to estimate probabilities of severe outcome for each condition-age group combination.ResultsCancer, cardiac disorder, diabetes, immunodeficiency, kidney, liver and lung disease, neurological disorders and obesity were associated with elevated risk (aOR: 1.5-5.6) of hospitalisation and death, after controlling for age, sex, reporting period and country. As age increased, age-specific aOR were lower and predicted probabilities higher. However, for some conditions, predicted probabilities were at least as high in younger individuals with the condition as in older cases without it. In multimorbid patients, the aOR for severe disease increased with number of conditions for all outcomes and in all age groups.ConclusionWhile supporting age-based vaccine roll-out, our findings could inform a more nuanced, age- and condition-specific approach to vaccine prioritisation. This is relevant as countries consider vaccination of younger people, boosters and dosing intervals in response to vaccine escape variants.", "doi": "10.2807/1560-7917.ES.2022.27.35.2100883", "pmid": "36052721", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9438397"}], "notes": [], "created": "2022-10-13T13:20:13.681Z", "modified": "2022-10-13T13:20:29.741Z"}, {"entity": "publication", "iuid": "cb78eca0dc3f4bbdba776bbbb624f273", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cb78eca0dc3f4bbdba776bbbb624f273.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cb78eca0dc3f4bbdba776bbbb624f273"}}, "title": "Acute Stress among Nurses in Sweden during the COVID-19 Pandemic.", "authors": [{"family": "Palmborg", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "L\u00f6tvall", "given": "Rebecka", "initials": "R"}, {"family": "Carde\u00f1a", "given": "Etzel", "initials": "E"}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Eur J Trauma Dissociation", "issn": "2468-7499", "issn-l": null, "volume": "6", "issue": "3", "pages": "100283"}, "abstract": "Sweden was hit hard in the beginning of the COVID-19 pandemic with deaths per capita among the highest in Europe. The pandemic was a stressful time especially for healthcare workers caring for COVID-19 patients. Various studies have evaluated whether nurses caring for these patients had higher levels of acute stress, but typically with measures that either used older DSM-IV criteria for Acute Stress Disorder (ASD) or general measures of acute stress. We recruited an online sample (N = 101) of nurses in Sweden from COVID-19 specialized units (ICU), Emergency (ER), and other units (Other), and asked them to answer questionnaires retrospectively to the peak of infections in Sweden. We aimed to evaluate: 1) the psychometric properties of the translation of the Stanford Acute Stress Reaction Questionnaire-II (SASRQ-II, which follows DSM-5 criteria for ASD) into Swedish, 2) whether nurses in COVID-19 units had experienced more acute stress than nurses in other units, and 3) the extent of potential acute stress disorder. The SASRQ-II evidenced good construct, convergent and divergent validity, and good reliability. It showed that ICU nurses reported significantly more acute stress than the other two groups, a difference that could not be accounted for by demographic or other variables. A retrospective diagnosis of ASD using the SASRQ-II suggested that 60% of nurses might have fulfilled ASD criteria, but no differences across groups were found.", "doi": "10.1016/j.ejtd.2022.100283", "pmid": "37521718", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC9153182"}, {"db": "pii", "key": "S2468-7499(22)00025-4"}], "notes": [], "created": "2023-10-04T12:10:42.579Z", "modified": "2023-10-04T13:29:52.549Z"}, {"entity": "publication", "iuid": "1de3abb226014908b7f0b2e74a72bc10", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1de3abb226014908b7f0b2e74a72bc10.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1de3abb226014908b7f0b2e74a72bc10"}}, "title": "Computational investigation of the increased virulence and pathogenesis of SARS-CoV-2 lineage B.1.1.7.", "authors": [{"family": "Murugan", "given": "N Arul", "initials": "NA", "orcid": "0000-0003-0185-5724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/293acfd743f94993bd6aca57b01cd604.json"}}, {"family": "Javali", "given": "Prashanth S", "initials": "PS"}, {"family": "Pandianb", "given": "Chitra Jeyaraj", "initials": "CJ"}, {"family": "Ali", "given": "Muhammad Akhtar", "initials": "MA"}, {"family": "Srivastava", "given": "Vaibhav", "initials": "V"}, {"family": "Jeyaraman", "given": "Jeyakanthan", "initials": "J"}], "type": "journal article", "published": "2022-08-31", "journal": {"title": "Phys Chem Chem Phys", "issn": "1463-9084", "volume": "24", "issue": "34", "pages": "20371-20380", "issn-l": null}, "abstract": "New variants of SARS-CoV-2 are being reported worldwide. The World Health Organization has reported Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2) and Omicron (B.1.1.529) as the variants of concern. There are speculations that the variants might evade the host immune responses induced by currently available vaccines and develop resistance to drugs under consideration. The first step of viral infection in COVID-19 occurs through the interaction of the spike protein's receptor-binding domain (RBD) with the peptidase domain of the human ACE-2 (hACE-2) receptor. This study aims to get a molecular-level understanding of the mechanism behind the increased infection rate in the alpha variant. We have computationally studied the spike protein interaction in both the wild-type and B.1.1.7 variant with the hACE-2 receptor using molecular dynamics and MM-GBSA based binding free energy calculations. The binding free energy difference shows that the mutant variant of the spike protein has increased binding affinity for the hACE-2 receptor (i.e. \u0394G(N501Y,A570D) is in the range -7.2 to -7.6 kcal mol-1) and the results were validated using Density functional theory. We demonstrate that with the use of state-of-the-art computational approaches, we can, in advance, predict the virulent nature of variants of SARS-CoV-2 and alert the world healthcare system.", "doi": "10.1039/d2cp00469k", "pmid": "35983778", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:46:02.036Z", "modified": "2022-09-12T18:46:11.422Z"}, {"entity": "publication", "iuid": "95b56a5bc5fd4409a812fb103435b7f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95b56a5bc5fd4409a812fb103435b7f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95b56a5bc5fd4409a812fb103435b7f8"}}, "title": "Target trial emulation: applying principles of randomised trials to observational studies.", "authors": [{"family": "Matthews", "given": "Anthony A", "initials": "AA"}, {"family": "Danaei", "given": "Goodarz", "initials": "G"}, {"family": "Islam", "given": "Nazrul", "initials": "N"}, {"family": "Kurth", "given": "Tobias", "initials": "T"}], "type": "journal article", "published": "2022-08-30", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "378", "pages": "e071108", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj-2022-071108", "pmid": "36041749", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-10-07T12:52:13.418Z", "modified": "2022-10-07T12:52:13.430Z"}, {"entity": "publication", "iuid": "7aea51599cb44f5bbd01b5b25ee4a2c3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7aea51599cb44f5bbd01b5b25ee4a2c3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7aea51599cb44f5bbd01b5b25ee4a2c3"}}, "title": "Standing alone: experiences of vaccine-hesitant Danish healthcare professionals during COVID-19.", "authors": [{"family": "Mars\u00e5", "given": "Kristoffer", "initials": "K"}, {"family": "Kristensen", "given": "Tina B\u00f8gelund", "initials": "TB", "orcid": "0000-0002-1337-2714", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04953b581b8d473f8775c9129a9cc439.json"}}, {"family": "Konradsen", "given": "Hanne", "initials": "H", "orcid": "0000-0002-7477-125X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b462d15cdeec4dcb8371e07cf2e97853.json"}}], "type": "journal article", "published": "2022-08-29", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "14034948221113645", "issn-l": "1403-4948"}, "abstract": "The aim of the study was to explore the experiences of Danish healthcare professionals who were hesitant about the COVID-19 vaccine.\n\nInterviews were conducted over the telephone in January and February 2021.\n\nHealthcare professionals experienced the need to avoid impossible conversations about vaccine hesitancy with their colleagues. They felt a lack of knowledge of long-term experience with the vaccine and a need to balance trust in themselves and the authorities.\n\nHealthcare professionals who were hesitant towards the COVID-19 vaccine felt they had to keep their concerns to themselves and felt isolated and pressured by their managers. This study is especially important for managers, who must ensure a trusting working environment in which employees can discuss their concerns without feeling pressured.", "doi": "10.1177/14034948221113645", "pmid": "36032021", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9425156"}], "notes": [], "created": "2022-10-07T12:42:10.132Z", "modified": "2022-10-07T12:42:10.202Z"}, {"entity": "publication", "iuid": "a10443d35eb74f0f9cf02dc552aa961f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a10443d35eb74f0f9cf02dc552aa961f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a10443d35eb74f0f9cf02dc552aa961f"}}, "title": "Early coronavirus disease 2019 restrictive measures and changes in maternal characteristics, use of assisted reproductive technology, and stillbirth.", "authors": [{"family": "Lisonkova", "given": "Sarka", "initials": "S", "orcid": "0000-0002-1220-310X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fa6497ba976450d811710f9d17d7cdf.json"}}, {"family": "Bone", "given": "Jeffrey N", "initials": "JN", "orcid": "0000-0001-7704-1677", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89c39d4178c944cda324b0f521aa290f.json"}}, {"family": "Muraca", "given": "Giulia M", "initials": "GM"}, {"family": "Razaz", "given": "Neda", "initials": "N", "orcid": "0000-0002-1273-0110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f21859df7854ccba80df15feb16afe1.json"}}, {"family": "Boutin", "given": "Amelie", "initials": "A", "orcid": "0000-0003-1907-2920", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cc105166eb549ed85144b0066c7cb8c.json"}}, {"family": "Brandt", "given": "Justin S", "initials": "JS", "orcid": "0000-0002-3194-1087", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90c6660c689c499c996f99485ece89f5.json"}}, {"family": "Bedaiwy", "given": "Mohamed A", "initials": "MA"}, {"family": "Ananth", "given": "Cande V", "initials": "CV", "orcid": "0000-0002-0410-2595", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/efc995667f254ca7b334d8acb15bf40c.json"}}, {"family": "Joseph", "given": "K S", "initials": "KS", "orcid": "0000-0003-2317-5607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56f6530185df4ed0884f76187da81fc1.json"}}], "type": "journal article", "published": "2022-08-29", "journal": {"title": "Paediatr Perinat Epidemiol", "issn": "1365-3016", "issn-l": null}, "abstract": "The initial COVID-19 pandemic response-related effects on conceptions following the use of assisted reproductive technologies (ART), and on changes in the maternal characteristics of women who conceived during the early vs. pre-pandemic period, have been understudied.\n\nTo examine the effects of ART clinic closures in the United States (US) in March 2020 on the frequency of ART-conceived live births, multiple births and stillbirths; and to describe changes in the characteristics of women who conceived in the early pandemic period.\n\nPopulation-based cohort study including all births in the US from January 2015 to December 2020 (22,907,688 live births; 134,537 stillbirths). Interrupted time series (ITS) methodology was used to estimate rate ratios (RR) of expected versus observed rates in December 2020 (i.e., among births conceived mainly in March 2020). Demographic and clinical characteristics were compared between mothers who conceived in March 2020 versus March 2015-2019.\n\nOverall, 1.1% of live births and 1.7% of stillbirths were conceived by ART. ART-conceived live births decreased by 57.0% in December 2020 (observed vs. expected RR 0.43, 95% confidence interval [CI] 0.40, 0.45), and these declines occurred in all subgroups of women. Multiple births also declined in December 2020. Stillbirth rates increased in December 2020 in ART-conceived births (RR 2.55, 95% CI 1.63, 3.92) but remained unchanged in the non-ART group. Maternal characteristics of women who conceived in the early pandemic versus pre-pandemic period differed and included an increased prevalence of pre-pregnancy obesity class 3 and chronic hypertension.\n\nThe early pandemic closure of ART clinics resulted in a substantial decline in ART-conceived live births and multiple births in December 2020 and an increase in the proportion of stillbirths among ART-conceived births. Women who conceived in the early pandemic period also had an increased prevalence of obesity and chronic hypertension.", "doi": "10.1111/ppe.12925", "pmid": "36038519", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-10-07T12:46:40.148Z", "modified": "2022-10-07T12:46:40.410Z"}, {"entity": "publication", "iuid": "3b7806103bd5433bb21a91e8f197bef2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b7806103bd5433bb21a91e8f197bef2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b7806103bd5433bb21a91e8f197bef2"}}, "title": "Vascular Aging and COVID-19.", "authors": [{"family": "Badaras", "given": "Ignas", "initials": "I", "orcid": "0000-0002-9423-6641", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/454778bb8e734071b6de754a38336a45.json"}}, {"family": "Lau\u010dyt\u0117-Cibulskien\u0117", "given": "Agn\u0117", "initials": "A"}], "type": "journal article", "published": "2022-08-28", "journal": {"title": "Angiology", "issn": "1940-1574", "pages": "33197221121007", "issn-l": null}, "abstract": "Vascular age is determined by functional and structural changes in the arterial wall. When measured by its proxy, pulse wave velocity, it has been shown to predict cardiovascular and total mortality. Disconcordance between chronological and vascular age might represent better or worse vascular health. Cell senescence is caused by oxidative stress and sustained cell replication. Senescent cells acquire senescence-associated secretory phenotype. Oxidative stress, endothelial dysfunction, dysregulation of coagulation and leucocyte infiltration are observed in the aging endothelium. All of these mechanisms lead to increased vascular calcification and stiffness. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can involve the vascular endothelium. It enters cells using angiotensin-converting enzyme 2 (ACE-2) receptors, which are abundant in endothelial cells. The damage this virus does to the endothelium can be direct or indirect. Indirect damage is caused by hyperinflammation. Direct damage results from effects on ACE-2 receptors. The reduction of ACE-2 levels seen during coronavirus disease 2019 (COVID-19) infection might cause vasoconstriction and oxidative stress. COVID-19 and vascular aging share some pathways. Due to the novelty of the virus, there is an urgent need for studies that investigate its long-term effects on vascular health.", "doi": "10.1177/00033197221121007", "pmid": "36031949", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9421419"}], "notes": [], "created": "2022-10-07T12:41:44.367Z", "modified": "2022-10-07T12:41:44.456Z"}, {"entity": "publication", "iuid": "40f0eb51bec5406f9a482adfb5912ef0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/40f0eb51bec5406f9a482adfb5912ef0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/40f0eb51bec5406f9a482adfb5912ef0"}}, "title": "Impact of the COVID-19 pandemic on total, sex- and age-specific all-cause mortality in 20 countries worldwide during 2020: results from the C-MOR project.", "authors": [{"family": "Demetriou", "given": "Christiana A", "initials": "CA"}, {"family": "Achilleos", "given": "Souzana", "initials": "S"}, {"family": "Quattrocchi", "given": "Annalisa", "initials": "A"}, {"family": "Gabel", "given": "John", "initials": "J"}, {"family": "Critselis", "given": "Elena", "initials": "E"}, {"family": "Constantinou", "given": "Constantina", "initials": "C"}, {"family": "Nicolaou", "given": "Nicoletta", "initials": "N"}, {"family": "Ambrosio", "given": "Giuseppe", "initials": "G"}, {"family": "Bennett", "given": "Catherine M", "initials": "CM"}, {"family": "Le Meur", "given": "Nolwenn", "initials": "N", "orcid": "0000-0001-8451-4014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7ccd56127144ac4b7044dfaf98ca8e6.json"}}, {"family": "Critchley", "given": "Julia A", "initials": "JA"}, {"family": "Mortensen", "given": "Laust Hvas", "initials": "LH"}, {"family": "Rodriguez-Llanes", "given": "Jose Manuel", "initials": "JM", "orcid": "0000-0003-3736-736X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/63855d33d8924205b7a3f4cf7f826ee2.json"}}, {"family": "Chong", "given": "Mario", "initials": "M"}, {"family": "Denissov", "given": "Gleb", "initials": "G"}, {"family": "Klepac", "given": "Petra", "initials": "P"}, {"family": "Goldsmith", "given": "Lucy P", "initials": "LP"}, {"family": "Costa", "given": "Antonio Jos\u00e9 Leal", "initials": "AJL"}, {"family": "Hagen", "given": "Terje P", "initials": "TP"}, {"family": "Chan Sun", "given": "Marie", "initials": "M"}, {"family": "Huang", "given": "Qian", "initials": "Q"}, {"family": "Pidmurniak", "given": "Nataliia", "initials": "N"}, {"family": "Zucker", "given": "Inbar", "initials": "I"}, {"family": "Cuthbertson", "given": "Joseph", "initials": "J"}, {"family": "Burstr\u00f6m", "given": "Bo", "initials": "B"}, {"family": "Barron", "given": "Manuel", "initials": "M"}, {"family": "Er\u017een", "given": "Ivan", "initials": "I"}, {"family": "Stracci", "given": "Fabrizio", "initials": "F"}, {"family": "Calmon", "given": "Wilson", "initials": "W"}, {"family": "Martial", "given": "Cyndy", "initials": "C"}, {"family": "Verstiuk", "given": "Olesia", "initials": "O"}, {"family": "Kaufman", "given": "Zalman", "initials": "Z"}, {"family": "Tao", "given": "Wenjing", "initials": "W"}, {"family": "Kereselidze", "given": "Maia", "initials": "M"}, {"family": "Chikhladze", "given": "Nino", "initials": "N"}, {"family": "Polemitis", "given": "Antonis", "initials": "A"}, {"family": "Charalambous", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2022-08-27", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "issn-l": "0300-5771"}, "abstract": "To understand the impact of the COVID-19 pandemic on mortality, this study investigates overall, sex- and age-specific excess all-cause mortality in 20 countries, during 2020.\n\nTotal, sex- and age-specific weekly all-cause mortality for 2015-2020 was collected from national vital statistics databases. Excess mortality for 2020 was calculated by comparing weekly 2020 observed mortality against expected mortality, estimated from historical data (2015-2019) accounting for seasonality, long- and short-term trends. Crude and age-standardized rates were analysed for total and sex-specific mortality.\n\nAustria, Brazil, Cyprus, England and Wales, France, Georgia, Israel, Italy, Northern Ireland, Peru, Scotland, Slovenia, Sweden, and the USA displayed substantial excess age-standardized mortality of varying duration during 2020, while Australia, Denmark, Estonia, Mauritius, Norway, and Ukraine did not. In sex-specific analyses, excess mortality was higher in males than females, except for Slovenia (higher in females) and Cyprus (similar in both sexes). Lastly, for most countries substantial excess mortality was only detectable (Austria, Cyprus, Israel, and Slovenia) or was higher (Brazil, England and Wales, France, Georgia, Italy, Northern Ireland, Sweden, Peru and the USA) in the oldest age group investigated. Peru demonstrated substantial excess mortality even in the <45 age group.\n\nThis study highlights that excess all-cause mortality during 2020 is context dependent, with specific countries, sex- and age-groups being most affected. As the pandemic continues, tracking excess mortality is important to accurately estimate the true toll of COVID-19, while at the same time investigating the effects of changing contexts, different variants, testing, quarantine, and vaccination strategies.", "doi": "10.1093/ije/dyac170", "pmid": "36029524", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6678067"}, {"db": "pmc", "key": "PMC9452146"}], "notes": [], "created": "2022-10-07T12:39:47.036Z", "modified": "2022-10-07T12:39:47.118Z"}, {"entity": "publication", "iuid": "f128d077fdaf4127bdbe1a3b9f04c3af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f128d077fdaf4127bdbe1a3b9f04c3af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f128d077fdaf4127bdbe1a3b9f04c3af"}}, "title": "Presentations of children to emergency departments across Europe and the COVID-19 pandemic: A multinational observational study.", "authors": [{"family": "Nijman", "given": "Ruud G", "initials": "RG", "orcid": "0000-0001-9671-8161", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26477162984840c0bf7a96f496f7c297.json"}}, {"family": "Honeyford", "given": "Kate", "initials": "K", "orcid": "0000-0002-5533-7693", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/106c36a2e1a8490686043452d0913882.json"}}, {"family": "Farrugia", "given": "Ruth", "initials": "R", "orcid": "0000-0002-1553-2486", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a73c5db5b3014380ac3872f27d73b578.json"}}, {"family": "Rose", "given": "Katy", "initials": "K", "orcid": "0000-0002-2020-4161", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be8a1e5aaf9c45b4a154d0f8a03d9974.json"}}, {"family": "Bognar", "given": "Zsolt", "initials": "Z", "orcid": "0000-0002-3744-9333", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e785ea593bba4834bdc5e3f23ddb815d.json"}}, {"family": "Buonsenso", "given": "Danilo", "initials": "D", "orcid": "0000-0001-8567-2639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e070622b9414c78b60ffe8128c2b199.json"}}, {"family": "Da Dalt", "given": "Liviana", "initials": "L", "orcid": "0000-0003-2977-3907", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e19bb4da28564137afdfb37221e0ed5c.json"}}, {"family": "De", "given": "Tisham", "initials": "T", "orcid": "0000-0001-7278-0534", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/326ea5db5b964d999e5476cd57954362.json"}}, {"family": "Maconochie", "given": "Ian K", "initials": "IK", "orcid": "0000-0001-6319-8550", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4777830b1d77433d8415df99b156c9d5.json"}}, {"family": "Parri", "given": "Niccolo", "initials": "N", "orcid": "0000-0002-8098-2504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b286f0ff29b402da7baa7f2fd324a1f.json"}}, {"family": "Roland", "given": "Damian", "initials": "D", "orcid": "0000-0001-9334-5144", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd56730130484fc29a5e6c8e30d39146.json"}}, {"family": "Alfven", "given": "Tobias", "initials": "T", "orcid": "0000-0002-2328-3512", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3851560b984401780a380ab1262cd8b.json"}}, {"family": "Aupiais", "given": "Camille", "initials": "C", "orcid": "0000-0001-7482-0405", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d81b1aa343a43129b778f6ff77da0f7.json"}}, {"family": "Barrett", "given": "Michael", "initials": "M", "orcid": "0000-0003-1775-8347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/55f3b1f81f834837af0d4e3d5c6a10bb.json"}}, {"family": "Basmaci", "given": "Romain", "initials": "R"}, {"family": "Borensztajn", "given": "Dorine", "initials": "D", "orcid": "0000-0002-2437-0757", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/916d54dab1494022b1e099689d96afe2.json"}}, {"family": "Castanhinha", "given": "Susana", "initials": "S", "orcid": "0000-0003-0762-7730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c3142588768e44a181ffeb24f1fc3968.json"}}, {"family": "Vasilico", "given": "Corrine", "initials": "C", "orcid": "0000-0001-8911-1097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/622935bca334454295b551f4b1a4ddd6.json"}}, {"family": "Durnin", "given": "Sheena", "initials": "S", "orcid": "0000-0002-5109-3417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ddf91f56cbd41e799cb59f67331a5dd.json"}}, {"family": "Fitzpatrick", "given": "Paddy", "initials": "P"}, {"family": "Fodor", "given": "Laszlo", "initials": "L", "orcid": "0000-0002-4984-4058", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6751db52f71146f49325f9ae87377ca3.json"}}, {"family": "Gomez", "given": "Borja", "initials": "B", "orcid": "0000-0001-6542-4494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21a0b7480f814dc9b295d90064ff20df.json"}}, {"family": "Greber-Platzer", "given": "Susanne", "initials": "S", "orcid": "0000-0002-3706-8370", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a396b96cb774df8b0d7ee369bdf31a0.json"}}, {"family": "Guedj", "given": "Romain", "initials": "R"}, {"family": "Hartshorn", "given": "Stuart", "initials": "S", "orcid": "0000-0003-0419-1564", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd07611e3974424596f1c06a15b0c64f.json"}}, {"family": "Hey", "given": "Florian", "initials": "F", "orcid": "0000-0001-6183-5798", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40a5401c6a28450fa7739f459f5944cf.json"}}, {"family": "Jankauskaite", "given": "Lina", "initials": "L", "orcid": "0000-0002-6997-4917", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a66e27835a87452181c6d16d37d8a60d.json"}}, {"family": "Kohlfuerst", "given": "Daniela", "initials": "D", "orcid": "0000-0002-1188-9525", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c89a5b53f956492285bbd9eb41486dc4.json"}}, {"family": "Kolnik", "given": "Mojca", "initials": "M", "orcid": "0000-0003-4194-7295", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01ae84eef06542a69573bb235e792b2d.json"}}, {"family": "Lyttle", "given": "Mark D", "initials": "MD", "orcid": "0000-0002-8634-7210", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c196102c81b4abf843cdaed12fe1cd5.json"}}, {"family": "Ma\u00e7\u00e3o", "given": "Patr\u00edcia", "initials": "P"}, {"family": "Mascarenhas", "given": "Maria In\u00eas", "initials": "MI"}, {"family": "Messahel", "given": "Shrouk", "initials": "S", "orcid": "0000-0003-0645-3070", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2654e67acf45429f9c86751a25e1918c.json"}}, {"family": "\u00d6zkan", "given": "Esra Aky\u00fcz", "initials": "EA"}, {"family": "Pu\u010duka", "given": "Zanda", "initials": "Z", "orcid": "0000-0002-6070-3563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1eb4a8297132442aaccf4bf4f7541407.json"}}, {"family": "Reis", "given": "Sofia", "initials": "S"}, {"family": "Rybak", "given": "Alexis", "initials": "A", "orcid": "0000-0002-2898-3710", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eca3664e52894d278a9b8e58d8bd7572.json"}}, {"family": "Ryd Rinder", "given": "Malin", "initials": "M", "orcid": "0000-0002-2947-4117", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b87e79413e84d8bb0a71a16fa3975fc.json"}}, {"family": "Teksam", "given": "Ozlem", "initials": "O"}, {"family": "Turan", "given": "Caner", "initials": "C", "orcid": "0000-0001-9469-5162", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e60e2d771749443283698d7c9c68bbc4.json"}}, {"family": "Thors", "given": "Valt\u00fdr Stef\u00e1nsson", "initials": "VS", "orcid": "0000-0002-0976-9604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe040ce0586f4aa69a84c26a4e58c0bd.json"}}, {"family": "Velasco", "given": "Roberto", "initials": "R", "orcid": "0000-0003-0073-2650", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/492e63741600403ea7a19017f167b203.json"}}, {"family": "Bressan", "given": "Silvia", "initials": "S"}, {"family": "Moll", "given": "Henriette A", "initials": "HA", "orcid": "0000-0001-9304-3322", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ef2448fc7e34cb3bce7b402eb9852cf.json"}}, {"family": "Oostenbrink", "given": "Rianne", "initials": "R", "orcid": "0000-0001-7919-8934", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3902bdbd1604b67b1b29c8ef8890323.json"}}, {"family": "Titomanlio", "given": "Luigi", "initials": "L", "orcid": "0000-0003-4909-803X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b9f5485226f4651afe8e9fa3594cf94.json"}}, {"family": "in association with the REPEM network (Research in European Pediatric Emergency Medicine) as part of the EPISODES study group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-08-26", "journal": {"title": "PLoS Med", "issn": "1549-1676", "volume": "19", "issue": "8", "pages": "e1003974", "issn-l": "1549-1277"}, "abstract": "During the initial phase of the Coronavirus Disease 2019 (COVID-19) pandemic, reduced numbers of acutely ill or injured children presented to emergency departments (EDs). Concerns were raised about the potential for delayed and more severe presentations and an increase in diagnoses such as diabetic ketoacidosis and mental health issues. This multinational observational study aimed to study the number of children presenting to EDs across Europe during the early COVID-19 pandemic and factors influencing this and to investigate changes in severity of illness and diagnoses.\n\nRoutine health data were extracted retrospectively from electronic patient records of children aged 18 years and under, presenting to 38 EDs in 16 European countries for the period January 2018 to May 2020, using predefined and standardized data domains. Observed and predicted numbers of ED attendances were calculated for the period February 2020 to May 2020. Poisson models and incidence rate ratios (IRRs), using predicted counts for each site as offset to adjust for case-mix differences, were used to compare age groups, diagnoses, and outcomes. Reductions in pediatric ED attendances, hospital admissions, and high triage urgencies were seen in all participating sites. ED attendances were relatively higher in countries with lower SARS-CoV-2 prevalence (IRR 2\u00b726, 95% CI 1\u00b790 to 2\u00b770, p < 0.001) and in children aged <12 months (12 to <24 months IRR 0\u00b786, 95% CI 0\u00b784 to 0\u00b789; 2 to <5 years IRR 0\u00b780, 95% CI 0\u00b778 to 0\u00b782; 5 to <12 years IRR 0\u00b768, 95% CI 0\u00b767 to 0\u00b770; 12 to 18 years IRR 0\u00b772, 95% CI 0\u00b770 to 0\u00b774; versus age <12 months as reference group, p < 0.001). The lowering of pediatric intensive care admissions was not as great as that of general admissions (IRR 1\u00b730, 95% CI 1\u00b716 to 1\u00b745, p < 0.001). Lower triage urgencies were reduced more than higher triage urgencies (urgent triage IRR 1\u00b710, 95% CI 1\u00b708 to 1\u00b712; emergent and very urgent triage IRR 1\u00b753, 95% CI 1\u00b749 to 1\u00b757; versus nonurgent triage category, p < 0.001). Reductions were highest and sustained throughout the study period for children with communicable infectious diseases. The main limitation was the retrospective nature of the study, using routine clinical data from a wide range of European hospitals and health systems.\n\nReductions in ED attendances were seen across Europe during the first COVID-19 lockdown period. More severely ill children continued to attend hospital more frequently compared to those with minor injuries and illnesses, although absolute numbers fell.\n\nISRCTN91495258 https://www.isrctn.com/ISRCTN91495258.", "doi": "10.1371/journal.pmed.1003974", "pmid": "36026507", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PMEDICINE-D-22-00899"}], "notes": [], "created": "2022-09-12T19:15:08.788Z", "modified": "2022-09-12T19:15:09.744Z"}, {"entity": "publication", "iuid": "019dcb91399048119825bcefe2415ec4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/019dcb91399048119825bcefe2415ec4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/019dcb91399048119825bcefe2415ec4"}}, "title": "Face mask use during the COVID-19 pandemic: how risk perception, experience with COVID-19, and attitude towards government interact with country-wide policy stringency.", "authors": [{"family": "Wismans", "given": "Annelot", "initials": "A"}, {"family": "van der Zwan", "given": "Peter", "initials": "P"}, {"family": "Wennberg", "given": "Karl", "initials": "K"}, {"family": "Franken", "given": "Ingmar", "initials": "I"}, {"family": "Mukerjee", "given": "Jinia", "initials": "J"}, {"family": "Baptista", "given": "Rui", "initials": "R"}, {"family": "Mar\u00edn", "given": "Jorge Barrientos", "initials": "JB"}, {"family": "Burke", "given": "Andrew", "initials": "A"}, {"family": "Dejardin", "given": "Marcus", "initials": "M"}, {"family": "Janssen", "given": "Frank", "initials": "F"}, {"family": "Letina", "given": "Srebrenka", "initials": "S"}, {"family": "Mill\u00e1n", "given": "Jos\u00e9 Mar\u00eda", "initials": "JM"}, {"family": "Santarelli", "given": "Enrico", "initials": "E"}, {"family": "Torr\u00e8s", "given": "Olivier", "initials": "O"}, {"family": "Thurik", "given": "Roy", "initials": "R"}], "type": "journal article", "published": "2022-08-26", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "1622", "issn-l": null}, "abstract": "During the 2020 COVID-19 pandemic, governments imposed numerous regulations to protect public health, particularly the (mandatory) use of face masks. However, the appropriateness and effectiveness of face mask regulations have been widely discussed, as is apparent from the divergent measures taken across and within countries over time, including mandating, recommending, and discouraging their use. In this study, we analyse how country-level policy stringency and individual-level predictors associate with face mask use during the early stages of the global COVID-19 pandemic.\n\nFirst, we study how (self and other-related) risk perception, (direct and indirect) experience with COVID-19, attitude towards government and policy stringency shape face mask use. Second, we study whether there is an interaction between policy stringency and the individual-level variables. We conduct multilevel analyses exploiting variation in face mask regulations across countries and using data from approximately 7000 students collected in the beginning of the pandemic (weeks 17 through 19, 2020).\n\nWe show that policy stringency is strongly positively associated with face mask use. We find a positive association between self-related risk perception and mask use, but no relationship of mask use with experience with COVID-19 and attitudes towards government. However, in the interaction analyses, we find that government trust and perceived clarity of communication moderate the link between stringency and mask use, with positive government perceptions relating to higher use in countries with regulations and to lower use in countries without regulations.\n\nWe highlight that those countries that aim for widespread use of face masks should set strict measures, stress self-related risks of COVID-19, and use clear communication.", "doi": "10.1186/s12889-022-13632-9", "pmid": "36028876", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-022-13632-9"}, {"db": "pmc", "key": "PMC9412789"}], "notes": [], "created": "2022-10-07T12:37:59.851Z", "modified": "2022-10-07T12:39:28.164Z"}, {"entity": "publication", "iuid": "178091f103d9489385c75bfcc5e42ed3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/178091f103d9489385c75bfcc5e42ed3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/178091f103d9489385c75bfcc5e42ed3"}}, "title": "Call for a unified approach to Monkeypox infection in pregnancy: Lessons from the COVID-19 pandemic.", "authors": [{"family": "Khalil", "given": "Asma", "initials": "A", "orcid": "0000-0003-2802-7670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e4558e368114cfb83c4594f523b38c0.json"}}, {"family": "Samara", "given": "Athina", "initials": "A", "orcid": "0000-0001-6931-1972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ef0cd4edca4b2a837d2b275da0be56.json"}}, {"family": "O'Brien", "given": "Pat", "initials": "P"}, {"family": "Ladhani", "given": "Shamez", "initials": "S"}], "type": "journal article", "published": "2022-08-26", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "5038", "issn-l": "2041-1723"}, "abstract": null, "doi": "10.1038/s41467-022-32638-w", "pmid": "36028491", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-022-32638-w"}, {"db": "pmc", "key": "PMC9412782"}], "notes": [], "created": "2022-10-07T12:37:23.211Z", "modified": "2022-10-07T12:37:35.174Z"}, {"entity": "publication", "iuid": "fb18b1397aad4f3c80a2af8860e8d27c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb18b1397aad4f3c80a2af8860e8d27c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb18b1397aad4f3c80a2af8860e8d27c"}}, "title": "Relatives' perspectives on encounters and communication in nursing homes during the Covid-19 pandemic: a qualitative interview study.", "authors": [{"family": "Eriksson", "given": "Elisabet", "initials": "E"}, {"family": "Hjelm", "given": "Katarina", "initials": "K"}], "type": "journal article", "published": "2022-08-25", "journal": {"title": "BMC Geriatr", "issn": "1471-2318", "volume": "22", "issue": "1", "pages": "706", "issn-l": null}, "abstract": "Relatives of nursing home (NH) residents have experienced national or local restrictions on visiting their elderly family member during the Covid-19 pandemic. Today, many NHs have a multicultural environment, as staff, residents and their relatives speak different languages. Thus far, studies of remote communication with staff with limited language skills during the Covid-19 pandemic are lacking.\n\nThe aim of the present study was to explore relatives' experiences of encounters and communication with staff and residents in NHs during the Covid-19 pandemic.\n\nAn explorative qualitative study using semi-structured telephone interviews with 17 relatives of NH residents (12 women and 5 men). Data were analyzed using qualitative content analysis to identify four main categories and nine sub-categories.\n\nCommunicating during visiting restrictions was challenging, and relatives experienced ups and downs when trying to stay in contact with NH residents and staff. Relatives received general information, but desired information about residents' everyday life without having to ask for it. Moreover, remote communication was difficult for residents with hearing impairment or dementia. Even relatives who understood different languages had to develop strategies to communicate with staff with limited language skills in Swedish and English. Relatives did not mention using translating applications to facilitate communication.\n\nDuring visiting restrictions, relatives lacked information about residents' everyday life and found communication with staff with limited language skills challenging. For this reason, and to enable communication with staff with limited language skills, there is a need to find practical and technical solutions for facilitating remote communication between relatives, residents and staff at NHs.", "doi": "10.1186/s12877-022-03364-1", "pmid": "36008775", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12877-022-03364-1"}, {"db": "pmc", "key": "PMC9409621"}], "notes": [], "created": "2022-09-12T19:08:33.469Z", "modified": "2022-09-12T19:08:33.475Z"}, {"entity": "publication", "iuid": "4b584f3911754e1a8a9dcdc1f132a940", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b584f3911754e1a8a9dcdc1f132a940.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b584f3911754e1a8a9dcdc1f132a940"}}, "title": "Global safety monitoring of COVID-19 vaccines: how pharmacovigilance rose to the challenge.", "authors": [{"family": "Rudolph", "given": "Annette", "initials": "A", "orcid": "0000-0003-2360-7174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5f0f8bf831a4539b0b7939d8a68ce73.json"}}, {"family": "Mitchell", "given": "Joseph", "initials": "J"}, {"family": "Barrett", "given": "Jim", "initials": "J"}, {"family": "Sk\u00f6ld", "given": "Helena", "initials": "H"}, {"family": "Taavola", "given": "Henric", "initials": "H"}, {"family": "Erlanson", "given": "Nils", "initials": "N"}, {"family": "Melgarejo-Gonz\u00e1lez", "given": "Carlos", "initials": "C"}, {"family": "Yue", "given": "Qun-Ying", "initials": "QY"}], "type": "journal article", "published": "2022-08-25", "journal": {"title": "Ther Adv Drug Saf", "issn": "2042-0986", "volume": "13", "pages": "20420986221118972", "issn-l": null}, "abstract": "Pharmacovigilance (PV) came suddenly into the spotlight when several new vaccines, developed as a response to the COVID-19 pandemic, received emergency authorisation and were rolled out on a large scale in late 2020. The vaccines underwent stringent clinical trials and evaluation from regulatory authorities, but with the use of novel technology and an anticipated rapid and vast deployment of the vaccines, the importance of a well-functioning international post marketing safety surveillance system was stressed. International PV stakeholders were faced with several challenges due to the extent of the global vaccination campaign. The unprecedented volume of reports of suspected adverse events following immunization has led to the development and use of new tools. Furthermore, the collaboration between various PV stakeholders was encouraged and strengthened. PV rose to the challenges posed by the currently ongoing global COVID-19 vaccination campaign and successful adaptations were made in a short period of time. However, the pandemic has not ended yet, the vaccination campaign is far from being completed, and further challenges are anticipated. Advances made during the pandemic will be important to strengthen PV in future and ensure to advance medicines' safety together.\n\nGlobal safety monitoring of the COVID-19 vaccines: challenges, preparations, and outlooks Pharmacovigilance (PV) is the umbrella term for all sciences and activities relating to the detection, assessment, understanding, and prevention of adverse effects relating to medicines or vaccines. PV came into the spotlight when several new vaccines were authorised and rolled out as a response to the COVID-19 pandemic.The anticipated extent of the global vaccine rollout stressed the importance of a well-functioning safety surveillance system and international collaborations between patients, health care workers, vaccine producers, regulatory authorities, and PV centres.The identification and communication of potential safety concerns showed that adaptations to PV processes made in a short period of time as well as international collaborations were successful. However, it is important to learn from experiences made so far and to make sure the positive advances are maintained in the future to advance medicines' safety together.", "doi": "10.1177/20420986221118972", "pmid": "36052399", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1177_20420986221118972"}, {"db": "pmc", "key": "PMC9424876"}], "notes": [], "created": "2022-10-13T13:19:14.175Z", "modified": "2022-10-13T13:19:40.906Z"}, {"entity": "publication", "iuid": "e069bf0f7d774e09ba6cec9630efdec7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e069bf0f7d774e09ba6cec9630efdec7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e069bf0f7d774e09ba6cec9630efdec7"}}, "title": "Testing for coronarvirus disease 2019 before cardiac surgery-safe outcome of infected patients.", "authors": [{"family": "Ivert", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Dal\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2022-08-24", "journal": {"title": "J Cardiothorac Surg", "issn": "1749-8090", "volume": "17", "issue": "1", "pages": "201", "issn-l": null}, "abstract": "The aim was to analyze routine preoperative testing for coronavirus disease 2019 (COVID-19) performed to avoid infected cardiac surgical patients transmitting virus during the pandemic.\n\nEvery patient scheduled to undergo cardiac surgery from March 2020 through December 2021 had preoperative polymerase-chain-reaction (PCR) test for COVID-19 by nasopharynx swabs. Any history of COVID-19 was recorded.\n\nIn 15 of 1870 patients (0.8%) with minimal or no airway symptoms unexpected positive PCR tests were detected, and surgery was deferred for two weeks. Totally 38 patients with negative tests had recovered without sequelae from previous COVID-19 a mean of 5 months before the operation. Sixteen patients (0.8%) developed airway symptoms within six weeks after the operation and had positive COVID-19 tests. Body Mass Index was higher and female gender, diabetes mellitus, chronic obstructive pulmonary disease and reduced left ventricular ejection fraction were more common in patients with than in those without COVID-19. Early postoperative outcomes did not differ significantly in patients with versus without COVID-19.\n\nAn unexpected preoperative positive COVID-19 test was detected in less than one percent of patients admitted for cardiac surgery during the pandemic. These operations were deferred to avoid transmission of virus in the hospital. Additionally, one percent of patients were diagnosed with positive COVID-19 tests within six weeks after the operation. There was no outbreak of COVID-19 among hospital staff or patients. All patients with COVID-19 before the operation were operated on safely and postoperative outcomes did not differ significantly compared with COVID-19 negative patients.", "doi": "10.1186/s13019-022-01960-1", "pmid": "36002897", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13019-022-01960-1"}], "notes": [], "created": "2022-08-26T04:43:06.006Z", "modified": "2022-08-26T04:43:07.222Z"}, {"entity": "publication", "iuid": "73c368a02dd448df81ac0b2d0060c6a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/73c368a02dd448df81ac0b2d0060c6a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/73c368a02dd448df81ac0b2d0060c6a1"}}, "title": "Experienced stigma and applied coping strategies during the COVID-19 pandemic in Germany: a mixed-methods study.", "authors": [{"family": "Peters", "given": "Lynn", "initials": "L", "orcid": "0000-0003-4882-6816", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ba436f73aa94aebad063825bea44f30.json"}}, {"family": "Burkert", "given": "Sanne", "initials": "S", "orcid": "0000-0002-9961-4170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/117c68feabcf4bc283cd0b542ea022f2.json"}}, {"family": "Brenner", "given": "Cecilia", "initials": "C"}, {"family": "Gr\u00fcner", "given": "Beate", "initials": "B", "orcid": "0000-0001-6669-3741", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c573876e2e9470badfe5d2b7498ac17.json"}}], "type": "journal article", "published": "2022-08-24", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "8", "pages": "e059472", "issn-l": "2044-6055"}, "abstract": "Health-related stigma is considered a social determinant of health equity and a hidden burden of disease. This study aimed to assess the level and dimensions of stigma and respective coping mechanisms in COVID-19 survivors.\n\nA mixed-methods study with sequential explanatory design was conducted at the University Hospital of Ulm, Germany. Stigma was assessed using the Social Impact Scale (SIS) including adult COVID-19 survivors with mild-to-severe disease. Subsequently, 14 participants were sampled with regard to gender, age and severity of disease for in-depth interviews to understand how stigma was experienced and coping strategies were applied. The questionnaire was analysed using descriptive statistics, t-test and analysis of variance. Content analysis was used for qualitative data.\n\nFrom 61 participants, 58% were men and mean age was 51 years. The quantitative analysis of the SIS indicated an intermediate level of experienced stigma. Participants experienced stigma mainly as 'social rejection' (M=14.22, SD=4.91), followed by 'social isolation' (M=10.17, SD=4.16) and 'internalised shame' (M=8.39, SD=3.32). There was no significant difference in experienced stigma regarding gender, education, occupational status or residual symptoms. However, participants between 30 and 39 years of age experienced higher levels of stigma than other age groups (p=0.034). The qualitative analysis revealed how stigma seemed to arise from misconceptions creating irrational fear of infection, leading to stereotyping, vilification, discrimination and social exclusion of COVID-19 survivors, leaving them feeling vulnerable. Stigma cut through all social levels, from the individual level at the bottom to the institutional and societal level at the top. Social networks protected from experiencing stigma.\n\nCOVID-19-related stigma is a relevant burden in the ongoing pandemic. Providing accurate information and exposing misinformation on disease prevention and treatment seems key to end COVID-19-related stigma.", "doi": "10.1136/bmjopen-2021-059472", "pmid": "36002206", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-059472"}], "notes": [], "created": "2022-08-26T04:43:29.779Z", "modified": "2022-08-26T04:43:29.903Z"}, {"entity": "publication", "iuid": "0c379fbf9ff74982b51c247c9d641a4b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c379fbf9ff74982b51c247c9d641a4b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c379fbf9ff74982b51c247c9d641a4b"}}, "title": "Characteristics and Outcomes of People With Gout Hospitalized Due to COVID-19: Data From the COVID-19 Global Rheumatology Alliance Physician-Reported Registry.", "authors": [{"family": "Jatuworapruk", "given": "Kanon", "initials": "K", "orcid": "0000-0002-9301-8941", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98c57555175a45dcae2058d1986dca81.json"}}, {"family": "Montgomery", "given": "Anna", "initials": "A", "orcid": "0000-0003-3333-7833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6be3cbe46a3b4190a31e190c195f7e77.json"}}, {"family": "Gianfrancesco", "given": "Milena", "initials": "M", "orcid": "0000-0002-8351-4626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dca9cada1314065ab094be6fc17524e.json"}}, {"family": "Conway", "given": "Richard", "initials": "R", "orcid": "0000-0003-2538-3362", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77fe264e6d0d4c87b734f3fa02e42c15.json"}}, {"family": "Durcan", "given": "Laura", "initials": "L", "orcid": "0000-0001-6585-2974", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/287c2710c1124f318c1c48f939654110.json"}}, {"family": "Graef", "given": "Elizabeth R", "initials": "ER", "orcid": "0000-0001-5973-3477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a80ffebe8ad44d34b27689cd1a699229.json"}}, {"family": "Jayatilleke", "given": "Aruni", "initials": "A", "orcid": "0000-0003-0875-4280", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a87e2f22a51b4e5c9300063078169b8a.json"}}, {"family": "Keen", "given": "Helen", "initials": "H", "orcid": "0000-0002-8469-2424", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fc442133e9f4dda9baa0b83d732ce63.json"}}, {"family": "Kilian", "given": "Adam", "initials": "A", "orcid": "0000-0002-5710-7859", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b5228c807444dce92cb2bf0ab3106b3.json"}}, {"family": "Young", "given": "Kristen", "initials": "K", "orcid": "0000-0001-8570-2228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a27d6eed12724bb6ab180caab8fb1c49.json"}}, {"family": "Carmona", "given": "Loreto", "initials": "L", "orcid": "0000-0002-4401-2551", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/798721bfd6a14e2f95267a56c5750ebe.json"}}, {"family": "Cogo", "given": "Adriana Karina", "initials": "AK", "orcid": "0000-0002-9172-8317", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b41c8b74eb548259e966d268c88ce34.json"}}, {"family": "Duarte-Garc\u00eda", "given": "Al\u00ed", "initials": "A", "orcid": "0000-0003-1749-5719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77a5555c1b624ba49ee7c729be2aef95.json"}}, {"family": "Gossec", "given": "Laure", "initials": "L", "orcid": "0000-0002-4528-310X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be93914dbc9b4abb936cbcaf202de05f.json"}}, {"family": "Hasseli", "given": "Rebecca", "initials": "R", "orcid": "0000-0002-2982-8253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aac4e1f1ceab4e72bb816a40c2f80c44.json"}}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL", "orcid": "0000-0001-8242-9262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9ad49b088eb467ba6d1ca1559b88047.json"}}, {"family": "Langlois", "given": "Vincent", "initials": "V", "orcid": "0000-0002-4078-6306", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c85cfd8a1a5f45d5a73aa4c265493431.json"}}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S", "orcid": "0000-0002-8611-162X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73b17eb08d984421847f733b7a6a49d4.json"}}, {"family": "Malcata", "given": "Armando", "initials": "A"}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Schafer", "given": "Martin", "initials": "M", "orcid": "0000-0001-6487-3634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb2c617a7902440eb574fcb1141785ac.json"}}, {"family": "Scir\u00e8", "given": "Carlo Alberto", "initials": "CA", "orcid": "0000-0001-7451-0271", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76ebc6c1acb94b2780a38dc4e8aea708.json"}}, {"family": "Sigurdardottir", "given": "Valgerdur", "initials": "V", "orcid": "0000-0002-9907-4901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a451adf9d32f47b09bee7c8ed0eb22ab.json"}}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA", "orcid": "0000-0002-5556-4618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/192552e5e3d2435799e57111ea84502d.json"}}, {"family": "Strangfeld", "given": "Anja", "initials": "A"}, {"family": "Xavier", "given": "Ricardo M", "initials": "RM", "orcid": "0000-0001-6570-4533", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8c4f81afb3d469cb1a6bc19c42fd9e0.json"}}, {"family": "Bhana", "given": "Suleman", "initials": "S", "orcid": "0000-0003-3805-0946", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d9785cdfa2c4e99ae10bfd9b042be46.json"}}, {"family": "Gore-Massy", "given": "Monique", "initials": "M"}, {"family": "Hausmann", "given": "Jonathan", "initials": "J", "orcid": "0000-0003-0786-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d99dc166f48d4af7b8e46dc999c7444b.json"}}, {"family": "Liew", "given": "Jean W", "initials": "JW", "orcid": "0000-0002-8104-2450", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8099c4a02b6e4c4789fc9e6895abfb01.json"}}, {"family": "Sirotich", "given": "Emily", "initials": "E", "orcid": "0000-0002-7087-8543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c5dfbc359844544aa3684d916185fac.json"}}, {"family": "Sufka", "given": "Paul", "initials": "P", "orcid": "0000-0003-3131-7919", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/164a147aef724296ae7987d6b230c31c.json"}}, {"family": "Wallace", "given": "Zach", "initials": "Z", "orcid": "0000-0003-4708-7038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4cf68e5aa1444f8c8f8164fd0493a850.json"}}, {"family": "Machado", "given": "Pedro M", "initials": "PM", "orcid": "0000-0002-8411-7972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef40d1eea57946e4a37d2e92a02a47cd.json"}}, {"family": "Yazdany", "given": "Jinoos", "initials": "J", "orcid": "0000-0002-3508-4094", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62bbeb3392ce40d482da768af63f5d54.json"}}, {"family": "Grainger", "given": "Rebecca", "initials": "R", "orcid": "0000-0001-9201-8678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9d304e9e29a43a5a7a76679c002a876.json"}}, {"family": "Robinson", "given": "Philip C", "initials": "PC", "orcid": "0000-0002-3156-3418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/950b622d31724172817ccde09902d215.json"}}], "type": "journal article", "published": "2022-08-24", "journal": {"title": "ACR Open Rheumatol", "issn": "2578-5745", "issn-l": null}, "abstract": "To describe people with gout who were diagnosed with coronavirus disease 2019 (COVID-19) and hospitalized and to characterize their outcomes.\n\nData on patients with gout hospitalized for COVID-19 between March 12, 2020, and October 25, 2021, were extracted from the COVID-19 Global Rheumatology Alliance registry. Descriptive statistics were used to describe the demographics, comorbidities, medication exposures, and COVID-19 outcomes including oxygenation or ventilation support and death.\n\nOne hundred sixty-three patients with gout who developed COVID-19 and were hospitalized were included. The mean age was 63 years, and 85% were male. The majority of the group lived in the Western Pacific Region (35%) and North America (18%). Nearly half (46%) had two or more comorbidities, with hypertension (56%), cardiovascular disease (28%), diabetes mellitus (26%), chronic kidney disease (25%), and obesity (23%) being the most common. Glucocorticoids and colchicine were used pre-COVID-19 in 11% and 12% of the cohort, respectively. Over two thirds (68%) of the cohort required supplemental oxygen or ventilatory support during hospitalization. COVID-19-related death was reported in 16% of the overall cohort, with 73% of deaths documented in people with two or more comorbidities.\n\nThis cohort of people with gout and COVID-19 who were hospitalized had high frequencies of ventilatory support and death. This suggests that patients with gout who were hospitalized for COVID-19 may be at risk of poor outcomes, perhaps related to known risk factors for poor outcomes, such as age and presence of comorbidity.", "doi": "10.1002/acr2.11495", "pmid": "36000538", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-26T04:43:49.533Z", "modified": "2022-08-26T04:43:50.160Z"}, {"entity": "publication", "iuid": "41327e2709a34ff8b1b94bc0e9185e82", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41327e2709a34ff8b1b94bc0e9185e82.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41327e2709a34ff8b1b94bc0e9185e82"}}, "title": "Respiratory and systemic monocytes, dendritic cells and myeloid-derived suppressor cells in COVID-19: Implications for disease severity.", "authors": [{"family": "Falck-Jones", "given": "Sara", "initials": "S"}, {"family": "\u00d6sterberg", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A", "orcid": "0000-0001-6966-7039", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0c96bf27aca45f6b460a555c5425e2d.json"}}], "type": "journal article", "published": "2022-08-23", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null}, "abstract": "Since the beginning of the SARS-CoV-2 pandemic in 2020, researchers worldwide have made efforts to understand the mechanisms behind the varying range of COVID-19 disease severity. Since the respiratory tract is the site of infection, and immune cells differ depending on their anatomical location, studying blood is not sufficient to understand the full immunopathogenesis in patients with COVID-19. It is becoming increasingly clear that monocytes, dendritic cells (DCs) and monocytic myeloid-derived suppressor cells (M-MDSCs) are involved in the immunopathology of COVID-19 and may play important roles in determining disease severity. Patients with mild COVID-19 display an early antiviral (interferon) response in the nasopharynx, expansion of activated intermediate monocytes and low levels of M-MDSCs in blood. In contrast, patients with severe COVID-19 seem to lack an early efficient induction of interferons, and skew towards a more suppressive response in blood. This is characterized by downregulation of activation markers and decreased functional capacity of blood monocytes and DCs, reduced circulating DCs and increased levels of HLA-DRlo CD14+ M-MDSCs. These suppressive characteristics could potentially contribute to delayed T cell responses in severe COVID-19 cases. In contrast, airways of patients with severe COVID-19 display hyperinflammation with elevated levels of inflammatory monocytes and monocyte-derived macrophages, and reduced levels of tissue-resident alveolar macrophages. These monocyte-derived cells contribute to excess inflammation by producing cytokines and chemokines. Here, we review the current knowledge on the role of monocytes, DCs and M-MDSCs in COVID-19 and how alterations and the anatomical distribution of these cell populations may relate to disease severity. This article is protected by copyright. All rights reserved.", "doi": "10.1111/joim.13559", "pmid": "35996885", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2022-08-26T04:45:51.973Z", "modified": "2022-08-26T04:45:52.027Z"}, {"entity": "publication", "iuid": "ef5efbb16ed3439d97267aef0736031a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef5efbb16ed3439d97267aef0736031a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef5efbb16ed3439d97267aef0736031a"}}, "title": "Genetic predispositions to psychiatric disorders and the risk of COVID-19.", "authors": [{"family": "Chen", "given": "Wenwen", "initials": "W"}, {"family": "Zeng", "given": "Yu", "initials": "Y"}, {"family": "Suo", "given": "Chen", "initials": "C"}, {"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Chen", "given": "Yilong", "initials": "Y"}, {"family": "Hou", "given": "Can", "initials": "C"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "Sun", "given": "Yajing", "initials": "Y"}, {"family": "Qu", "given": "Yuanyuan", "initials": "Y"}, {"family": "Lu", "given": "Donghao", "initials": "D"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Song", "given": "Huan", "initials": "H", "orcid": "0000-0003-3845-8079", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2e35902226b407487330fc6c7368759.json"}}], "type": "journal article", "published": "2022-08-23", "journal": {"title": "BMC Med", "issn": "1741-7015", "volume": "20", "issue": "1", "pages": "314", "issn-l": null}, "abstract": "Whether a genetic predisposition to psychiatric disorders is associated with coronavirus disease 2019 (COVID-19) is unknown.\n\nOur analytic sample consisted of 287,123 white British participants in UK Biobank who were alive on 31 January 2020. We performed a genome-wide association study (GWAS) analysis for each psychiatric disorder (substance misuse, depression, anxiety, psychotic disorder, and stress-related disorders) in a randomly selected half of the study population (\"base dataset\"). For the other half (\"target dataset\"), the polygenic risk score (PRS) was calculated as a proxy of individuals' genetic predisposition to a given psychiatric phenotype using discovered genetic variants from the base dataset. Ascertainment of COVID-19 was based on the Public Health England dataset, inpatient hospital data, or death registers in UK Biobank. COVID-19 cases from hospitalization records or death records were considered \"severe cases.\" The association between the PRS for psychiatric disorders and COVID-19 risk was examined using logistic regression. We also repeated PRS analyses based on publicly available GWAS summary statistics.\n\nA total of 143,562 participants (including 10,868 COVID-19 cases) were used for PRS analyses. A higher genetic predisposition to psychiatric disorders was associated with an increased risk of any COVID-19 and severe COVID-19. The adjusted odds ratio (OR) for any COVID-19 was 1.07 (95% confidence interval [CI] 1.02-1.13) and 1.06 (95% CI 1.01-1.11) among individuals with a high genetic risk (above the upper tertile of the PRS) for substance misuse and depression, respectively, compared with individuals with a low genetic risk (below the lower tertile). Slightly higher ORs were noted for severe COVID-19, and similar result patterns were obtained in analyses based on publicly available GWAS summary statistics.\n\nOur findings suggest a potential role of genetic factors in the observed phenotypic association between psychiatric disorders and COVID-19. Our data underscore the need for increased medical surveillance for this vulnerable population during the COVID-19 pandemic.", "doi": "10.1186/s12916-022-02520-z", "pmid": "35999565", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12916-022-02520-z"}], "notes": [], "created": "2022-08-26T04:44:51.899Z", "modified": "2022-08-26T04:44:51.929Z"}, {"entity": "publication", "iuid": "c9f20a46bf7a480c9d2cafe1fe5582e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9f20a46bf7a480c9d2cafe1fe5582e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9f20a46bf7a480c9d2cafe1fe5582e2"}}, "title": "Diffuse alveolar damage patterns reflect the immunological and molecular heterogeneity in fatal COVID-19.", "authors": [{"family": "Erjef\u00e4lt", "given": "Jonas S", "initials": "JS"}, {"family": "de Souza Xavier Costa", "given": "Nat\u00e1lia", "initials": "N"}, {"family": "J\u00f6nsson", "given": "Jimmie", "initials": "J"}, {"family": "Cozzolino", "given": "Olga", "initials": "O"}, {"family": "Dantas", "given": "Katia Cristina", "initials": "KC"}, {"family": "Clausson", "given": "Carl-Magnus", "initials": "CM"}, {"family": "Siddhuraj", "given": "Premkumar", "initials": "P"}, {"family": "Lind\u00f6", "given": "Caroline", "initials": "C"}, {"family": "Alyamani", "given": "Manar", "initials": "M"}, {"family": "Lombardi", "given": "Suzete Cleusa Ferreira Spina", "initials": "SCFS"}, {"family": "Mendroni J\u00fanior", "given": "Alfredo", "initials": "A"}, {"family": "Antonangelo", "given": "Leila", "initials": "L"}, {"family": "Faria", "given": "Caroline Silv\u00e9rio", "initials": "CS"}, {"family": "Duarte-Neto", "given": "Amaro Nunes", "initials": "AN"}, {"family": "de Almeida Monteiro", "given": "Renata Aparecida", "initials": "RA"}, {"family": "Rebello Pinho", "given": "Jo\u00e3o Renato", "initials": "JR"}, {"family": "Gomes-Gouv\u00eaa", "given": "Michele Soares", "initials": "MS"}, {"family": "Verciano Pereira", "given": "Roberta", "initials": "R"}, {"family": "Monteiro", "given": "Jhonatas Sirino", "initials": "JS"}, {"family": "Setubal", "given": "Jo\u00e3o Carlos", "initials": "JC"}, {"family": "de Oliveira", "given": "Ellen Pierre", "initials": "EP"}, {"family": "Theodoro Filho", "given": "Jair", "initials": "J"}, {"family": "Sanden", "given": "Caroline", "initials": "C"}, {"family": "Orengo", "given": "Jamie M", "initials": "JM"}, {"family": "Sleeman", "given": "Matthew A", "initials": "MA"}, {"family": "da Silva", "given": "Luiz Fernando Ferraz", "initials": "LFF"}, {"family": "Saldiva", "given": "Paulo Hil\u00e1rio Nascimento", "initials": "PHN"}, {"family": "Dolhnikoff", "given": "Marisa", "initials": "M"}, {"family": "Mauad", "given": "Thais", "initials": "T"}], "type": "journal article", "published": "2022-08-23", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "volume": "83", "pages": "104229", "issn-l": null}, "abstract": "Severe COVID-19 lung disease exhibits a high degree of spatial and temporal heterogeneity, with different histological features coexisting within a single individual. It is important to capture the disease complexity to support patient management and treatment strategies. We provide spatially decoded analyses on the immunopathology of diffuse alveolar damage (DAD) patterns and factors that modulate immune and structural changes in fatal COVID-19.\n\nWe spatially quantified the immune and structural cells in exudative, intermediate, and advanced DAD through multiplex immunohistochemistry in autopsy lung tissue of 18 COVID-19 patients. Cytokine profiling, viral, bacteria, and fungi detection, and transcriptome analyses were performed.\n\nSpatial DAD progression was associated with expansion of immune cells, macrophages, CD8+ T cells, fibroblasts, and (lymph)angiogenesis. Viral load correlated positively with exudative DAD and negatively with disease/hospital length. In all cases, enteric bacteria were isolated, and Candida parapsilosis in eight cases. Cytokines correlated mainly with macrophages and CD8+T cells. Pro-coagulation and acute repair were enriched pathways in exudative DAD whereas intermediate/advanced DAD had a molecular profile of elevated humoral and innate immune responses and extracellular matrix production.\n\nUnraveling the spatial and molecular immunopathology of COVID-19 cases exposes the responses to SARS-CoV-2-induced exudative DAD and subsequent immune-modulatory and remodeling changes in proliferative/advanced DAD that occur side-by-side together with secondary infections in the lungs. These complex features have important implications for disease management and the development of novel treatments.\n\nCNPq, Bill and Melinda Gates Foundation, HC-Convida, FAPESP, Regeneron Pharmaceuticals, and the Swedish Heart & Lung Foundation.", "doi": "10.1016/j.ebiom.2022.104229", "pmid": "36027872", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2352-3964(22)00411-X"}, {"db": "pmc", "key": "PMC9398470"}], "notes": [], "created": "2022-09-12T19:15:23.961Z", "modified": "2022-09-12T19:15:23.966Z"}, {"entity": "publication", "iuid": "d616ec14309e4023a914ce720f7f17c4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d616ec14309e4023a914ce720f7f17c4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d616ec14309e4023a914ce720f7f17c4"}}, "title": "Clinical risk factors of adverse outcomes among women with COVID-19 in the pregnancy and postpartum period: A sequential, prospective meta-analysis.", "authors": [{"family": "Smith", "given": "Emily R", "initials": "ER"}, {"family": "Oakley", "given": "Erin", "initials": "E"}, {"family": "Grandner", "given": "Gargi Wable", "initials": "GW"}, {"family": "Rukundo", "given": "Gordon", "initials": "G"}, {"family": "Farooq", "given": "Fouzia", "initials": "F"}, {"family": "Ferguson", "given": "Kacey", "initials": "K"}, {"family": "Baumann", "given": "Sasha", "initials": "S"}, {"family": "Waldorf", "given": "Kristina Adams", "initials": "KA"}, {"family": "Afshar", "given": "Yalda", "initials": "Y"}, {"family": "Ahlberg", "given": "Mia", "initials": "M"}, {"family": "Ahmadzia", "given": "Homa", "initials": "H"}, {"family": "Akelo", "given": "Victor", "initials": "V"}, {"family": "Aldrovandi", "given": "Grace", "initials": "G"}, {"family": "Bevilacqua", "given": "Elisa", "initials": "E"}, {"family": "Bracero", "given": "Nabal", "initials": "N"}, {"family": "Brandt", "given": "Justin S", "initials": "JS"}, {"family": "Broutet", "given": "Natalie", "initials": "N"}, {"family": "Carrillo", "given": "Jorge", "initials": "J"}, {"family": "Conry", "given": "Jeanne", "initials": "J"}, {"family": "Cosmi", "given": "Erich", "initials": "E"}, {"family": "Crispi", "given": "Fatima", "initials": "F"}, {"family": "Crovetto", "given": "Francesca", "initials": "F"}, {"family": "Gil", "given": "Maria Del Mar", "initials": "MDM"}, {"family": "Delgado-L\u00f3pez", "given": "Camille", "initials": "C"}, {"family": "Divakar", "given": "Hema", "initials": "H"}, {"family": "Driscoll", "given": "Amanda J", "initials": "AJ"}, {"family": "Favre", "given": "Guillaume", "initials": "G"}, {"family": "Buhigas", "given": "Irene Fernandez", "initials": "IF"}, {"family": "Flaherman", "given": "Valerie", "initials": "V"}, {"family": "Gale", "given": "Christopher", "initials": "C"}, {"family": "Godwin", "given": "Christine L", "initials": "CL"}, {"family": "Gottlieb", "given": "Sami", "initials": "S"}, {"family": "Gratac\u00f3s", "given": "Eduard", "initials": "E"}, {"family": "He", "given": "Siran", "initials": "S"}, {"family": "Hernandez", "given": "Olivia", "initials": "O"}, {"family": "Jones", "given": "Stephanie", "initials": "S"}, {"family": "Joshi", "given": "Sheetal", "initials": "S"}, {"family": "Kalafat", "given": "Erkan", "initials": "E"}, {"family": "Khagayi", "given": "Sammy", "initials": "S"}, {"family": "Knight", "given": "Marian", "initials": "M"}, {"family": "Kotloff", "given": "Karen", "initials": "K"}, {"family": "Lanzone", "given": "Antonio", "initials": "A"}, {"family": "Longo", "given": "Valentina Laurita", "initials": "VL"}, {"family": "Le Doare", "given": "Kirsty", "initials": "K"}, {"family": "Lees", "given": "Christoph", "initials": "C"}, {"family": "Litman", "given": "Ethan", "initials": "E"}, {"family": "Lokken", "given": "Erica M", "initials": "EM"}, {"family": "Madhi", "given": "Shabir A", "initials": "SA"}, {"family": "Magee", "given": "Laura A", "initials": "LA"}, {"family": "Martinez-Portilla", "given": "Raigam Jafet", "initials": "RJ"}, {"family": "Metz", "given": "Torri D", "initials": "TD"}, {"family": "Miller", "given": "Emily S", "initials": "ES"}, {"family": "Money", "given": "Deborah", "initials": "D"}, {"family": "Moungmaithong", "given": "Sakita", "initials": "S"}, {"family": "Mullins", "given": "Edward", "initials": "E"}, {"family": "Nachega", "given": "Jean B", "initials": "JB"}, {"family": "Nunes", "given": "Marta C", "initials": "MC"}, {"family": "Onyango", "given": "Dickens", "initials": "D"}, {"family": "Panchaud", "given": "Alice", "initials": "A"}, {"family": "Poon", "given": "Liona C", "initials": "LC"}, {"family": "Raiten", "given": "Daniel", "initials": "D"}, {"family": "Regan", "given": "Lesley", "initials": "L"}, {"family": "Sahota", "given": "Daljit", "initials": "D"}, {"family": "Sakowicz", "given": "Allie", "initials": "A"}, {"family": "Sanin-Blair", "given": "Jose", "initials": "J"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}, {"family": "Temmerman", "given": "Marleen", "initials": "M"}, {"family": "Thorson", "given": "Anna", "initials": "A"}, {"family": "Thwin", "given": "Soe Soe", "initials": "SS"}, {"family": "Tippett Barr", "given": "Beth A", "initials": "BA"}, {"family": "Tolosa", "given": "Jorge E", "initials": "JE"}, {"family": "Tug", "given": "Niyazi", "initials": "N"}, {"family": "Valencia-Prado", "given": "Miguel", "initials": "M"}, {"family": "Visentin", "given": "Silvia", "initials": "S"}, {"family": "von Dadelszen", "given": "Peter", "initials": "P"}, {"family": "Whitehead", "given": "Clare", "initials": "C"}, {"family": "Wood", "given": "Mollie", "initials": "M"}, {"family": "Yang", "given": "Huixia", "initials": "H"}, {"family": "Zavala", "given": "Rebecca", "initials": "R"}, {"family": "Tielsch", "given": "James M", "initials": "JM"}], "type": "journal article", "published": "2022-08-23", "journal": {"title": "Am J Obstet Gynecol", "issn": "1097-6868", "issn-l": null}, "abstract": "This sequential, prospective meta-analysis (sPMA) sought to identify risk factors among pregnant and postpartum women with COVID-19 for adverse outcomes related to: disease severity, maternal morbidities, neonatal mortality and morbidity, adverse birth outcomes.\n\nWe prospectively invited study investigators to join the sPMA via professional research networks beginning in March 2020.\n\nEligible studies included those recruiting at least 25 consecutive cases of COVID-19 in pregnancy within a defined catchment area.\n\nWe included individual patient data from 21 participating studies. Data quality was assessed, and harmonized variables for risk factors and outcomes were constructed. Duplicate cases were removed. Pooled estimates for the absolute and relative risk of adverse outcomes comparing those with and without each risk factor were generated using a two-stage meta-analysis.\n\nWe collected data from 33 countries and territories, including 21,977 cases of SARS-CoV-2 infection in pregnancy or postpartum. We found that women with comorbidities (pre-existing diabetes, hypertension, cardiovascular disease) versus those without were at higher risk for COVID-19 severity and pregnancy health outcomes (fetal death, preterm birth, low birthweight). Participants with COVID-19 and HIV were 1.74 times (95% CI: 1.12, 2.71) more likely to be admitted to the ICU. Pregnant women who were underweight before pregnancy were at higher risk of ICU admission (RR 5.53, 95% CI: 2.27, 13.44), ventilation (RR 9.36, 95% CI: 3.87, 22.63), and pregnancy-related death (RR 14.10, 95% CI: 2.83, 70.36). Pre-pregnancy obesity was also a risk factor for severe COVID-19 outcomes including ICU admission (RR 1.81, 95% CI: 1.26,2.60), ventilation (RR 2.05, 95% CI: 1.20,3.51), any critical care (RR 1.89, 95% CI: 1.28,2.77), and pneumonia (RR 1.66, 95% CI: 1.18,2.33). Anemic pregnant women with COVID-19 also had increased risk of ICU admission (RR 1.63, 95% CI: 1.25, 2.11) and death (RR 2.36, 95% CI: 1.15, 4.81).\n\nWe found that pregnant women with comorbidities including diabetes, hypertension, and cardiovascular disease were at increased risk for severe COVID-19-related outcomes, maternal morbidities, and adverse birth outcomes. We also identified several less commonly-known risk factors, including HIV infection, pre-pregnancy underweight, and anemia. Although pregnant women are already considered a high-risk population, special priority for prevention and treatment should be given to pregnant women with these additional risk factors.", "doi": "10.1016/j.ajog.2022.08.038", "pmid": "36027953", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0002-9378(22)00680-9"}, {"db": "pmc", "key": "PMC9398561"}], "notes": [], "created": "2022-09-12T19:15:47.556Z", "modified": "2022-09-12T19:15:47.562Z"}, {"entity": "publication", "iuid": "255dd60f402c4f3da278ba0e771bd03f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/255dd60f402c4f3da278ba0e771bd03f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/255dd60f402c4f3da278ba0e771bd03f"}}, "title": "The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force.", "authors": [{"family": "Wang", "given": "Qingbo S", "initials": "QS"}, {"family": "Edahiro", "given": "Ryuya", "initials": "R"}, {"family": "Namkoong", "given": "Ho", "initials": "H"}, {"family": "Hasegawa", "given": "Takanori", "initials": "T"}, {"family": "Shirai", "given": "Yuya", "initials": "Y"}, {"family": "Sonehara", "given": "Kyuto", "initials": "K"}, {"family": "Tanaka", "given": "Hiromu", "initials": "H"}, {"family": "Lee", "given": "Ho", "initials": "H"}, {"family": "Saiki", "given": "Ryunosuke", "initials": "R", "orcid": "0000-0001-6984-7187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd5bae576b614b1f9e27c3975f2f72a2.json"}}, {"family": "Hyugaji", "given": "Takayoshi", "initials": "T"}, {"family": "Shimizu", "given": "Eigo", "initials": "E"}, {"family": "Katayama", "given": "Kotoe", "initials": "K", "orcid": "0000-0002-3966-1231", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68f93c3d200e45cea3eaea3a1758f0af.json"}}, {"family": "Kanai", "given": "Masahiro", "initials": "M", "orcid": "0000-0001-5165-4408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01d858a30cea453d91cedab1fd5c8494.json"}}, {"family": "Naito", "given": "Tatsuhiko", "initials": "T", "orcid": "0000-0002-2779-4600", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b0897a4c92b4ca781c81fc0d5520385.json"}}, {"family": "Sasa", "given": "Noah", "initials": "N"}, {"family": "Yamamoto", "given": "Kenichi", "initials": "K", "orcid": "0000-0001-9594-7050", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d494d739ff8469c9f6def67c94cb3ef.json"}}, {"family": "Kato", "given": "Yasuhiro", "initials": "Y"}, {"family": "Morita", "given": "Takayoshi", "initials": "T"}, {"family": "Takahashi", "given": "Kazuhisa", "initials": "K", "orcid": "0000-0001-5749-4118", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d5ac9fceb6f47ffabede76f02a183e4.json"}}, {"family": "Harada", "given": "Norihiro", "initials": "N"}, {"family": "Naito", "given": "Toshio", "initials": "T"}, {"family": "Hiki", "given": "Makoto", "initials": "M"}, {"family": "Matsushita", "given": "Yasushi", "initials": "Y"}, {"family": "Takagi", "given": "Haruhi", "initials": "H"}, {"family": "Ichikawa", "given": "Masako", "initials": "M"}, {"family": "Nakamura", "given": "Ai", "initials": "A"}, {"family": "Harada", "given": "Sonoko", "initials": "S"}, {"family": "Sandhu", "given": "Yuuki", "initials": "Y"}, {"family": "Kabata", "given": "Hiroki", "initials": "H"}, {"family": "Masaki", "given": "Katsunori", "initials": "K"}, {"family": "Kamata", "given": "Hirofumi", "initials": "H"}, {"family": "Ikemura", "given": "Shinnosuke", "initials": "S"}, {"family": "Chubachi", "given": "Shotaro", "initials": "S"}, {"family": "Okamori", "given": "Satoshi", "initials": "S"}, {"family": "Terai", "given": "Hideki", "initials": "H", "orcid": "0000-0002-1118-1930", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d4b3da553c9463a84199024fbe1c41b.json"}}, {"family": "Morita", "given": "Atsuho", "initials": "A"}, {"family": "Asakura", "given": "Takanori", "initials": "T", "orcid": "0000-0003-3122-6937", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2031e5d0b29849d6ba08e174e7da4834.json"}}, {"family": "Sasaki", "given": "Junichi", "initials": "J"}, {"family": "Morisaki", "given": "Hiroshi", "initials": "H"}, {"family": "Uwamino", "given": "Yoshifumi", "initials": "Y"}, {"family": "Nanki", "given": "Kosaku", "initials": "K"}, {"family": "Uchida", "given": "Sho", "initials": "S"}, {"family": "Uno", "given": "Shunsuke", "initials": "S"}, {"family": "Nishimura", "given": "Tomoyasu", "initials": "T"}, {"family": "Ishiguro", "given": "Takashri", "initials": "T"}, {"family": "Isono", "given": "Taisuke", "initials": "T"}, {"family": "Shibata", "given": "Shun", "initials": "S"}, {"family": "Matsui", "given": "Yuma", "initials": "Y"}, {"family": "Hosoda", "given": "Chiaki", "initials": "C"}, {"family": "Takano", "given": "Kenji", "initials": "K"}, {"family": "Nishida", "given": "Takashi", "initials": "T"}, {"family": "Kobayashi", "given": "Yoichi", "initials": "Y"}, {"family": "Takaku", "given": "Yotaro", "initials": "Y"}, {"family": "Takayanagi", "given": "Noboru", "initials": "N"}, {"family": "Ueda", "given": "Soichiro", "initials": "S"}, {"family": "Tada", "given": "Ai", "initials": "A"}, {"family": "Miyawaki", "given": "Masayoshi", "initials": "M"}, {"family": "Yamamoto", "given": "Masaomi", "initials": "M"}, {"family": "Yoshida", "given": "Eriko", "initials": "E"}, {"family": "Hayashi", "given": "Reina", "initials": "R"}, {"family": "Nagasaka", "given": "Tomoki", "initials": "T"}, {"family": "Arai", "given": "Sawako", "initials": "S"}, {"family": "Kaneko", "given": "Yutaro", "initials": "Y"}, {"family": "Sasaki", "given": "Kana", "initials": "K"}, {"family": "Tagaya", "given": "Etsuko", "initials": "E"}, {"family": "Kawana", "given": "Masatoshi", "initials": "M"}, {"family": "Arimura", "given": "Ken", "initials": "K"}, {"family": "Takahashi", "given": "Kunihiko", "initials": "K"}, {"family": "Anzai", "given": "Tatsuhiko", "initials": "T"}, {"family": "Ito", "given": "Satoshi", "initials": "S"}, {"family": "Endo", "given": "Akifumi", "initials": "A"}, {"family": "Uchimura", "given": "Yuji", "initials": "Y"}, {"family": "Miyazaki", "given": "Yasunari", "initials": "Y", "orcid": "0000-0002-9073-9815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cabd9b972ca24453957c822589b9bebd.json"}}, {"family": "Honda", "given": "Takayuki", "initials": "T"}, {"family": "Tateishi", "given": "Tomoya", "initials": "T"}, {"family": "Tohda", "given": "Shuji", "initials": "S"}, {"family": "Ichimura", "given": "Naoya", "initials": "N"}, {"family": "Sonobe", "given": "Kazunari", "initials": "K"}, {"family": "Sassa", "given": "Chihiro Tani", "initials": "CT"}, {"family": "Nakajima", "given": "Jun", "initials": "J"}, {"family": "Nakano", "given": "Yasushi", "initials": "Y"}, {"family": "Nakajima", "given": "Yukiko", "initials": "Y"}, {"family": "Anan", "given": "Ryusuke", "initials": "R"}, {"family": "Arai", "given": "Ryosuke", "initials": "R"}, {"family": "Kurihara", "given": "Yuko", "initials": "Y"}, {"family": "Harada", "given": "Yuko", "initials": "Y"}, {"family": "Nishio", "given": "Kazumi", "initials": "K"}, {"family": "Ueda", "given": "Tetsuya", "initials": "T"}, {"family": "Azuma", "given": "Masanori", "initials": "M"}, {"family": "Saito", "given": "Ryuichi", "initials": "R"}, {"family": "Sado", "given": "Toshikatsu", "initials": "T"}, {"family": "Miyazaki", "given": "Yoshimune", "initials": "Y"}, {"family": "Sato", "given": "Ryuichi", "initials": "R"}, {"family": "Haruta", "given": "Yuki", "initials": "Y"}, {"family": "Nagasaki", "given": "Tadao", "initials": "T"}, {"family": "Yasui", "given": "Yoshinori", "initials": "Y"}, {"family": "Hasegawa", "given": "Yoshinori", "initials": "Y"}, {"family": "Mutoh", "given": "Yoshikazu", "initials": "Y"}, {"family": "Kimura", "given": "Tomoki", "initials": "T"}, {"family": "Sato", "given": "Tomonori", "initials": "T"}, {"family": "Takei", "given": "Reoto", "initials": "R"}, {"family": "Hagimoto", "given": "Satoshi", "initials": "S"}, {"family": "Noguchi", "given": "Yoichiro", "initials": "Y"}, {"family": "Yamano", "given": "Yasuhiko", "initials": "Y"}, {"family": "Sasano", "given": "Hajime", "initials": "H"}, {"family": "Ota", "given": "Sho", "initials": "S"}, {"family": "Nakamori", "given": "Yasushi", "initials": "Y"}, {"family": "Yoshiya", "given": "Kazuhisa", "initials": "K"}, {"family": "Saito", "given": "Fukuki", "initials": "F"}, {"family": "Yoshihara", "given": "Tomoyuki", "initials": "T"}, {"family": "Wada", "given": "Daiki", "initials": "D"}, {"family": "Iwamura", "given": "Hiromu", "initials": "H"}, {"family": "Kanayama", "given": "Syuji", "initials": "S"}, {"family": "Maruyama", "given": "Shuhei", "initials": "S"}, {"family": "Yoshiyama", "given": "Takashi", "initials": "T"}, {"family": "Ohta", "given": "Ken", "initials": "K"}, {"family": "Kokuto", "given": "Hiroyuki", "initials": "H"}, {"family": "Ogata", "given": "Hideo", "initials": "H"}, {"family": "Tanaka", "given": "Yoshiaki", "initials": "Y"}, {"family": "Arakawa", "given": "Kenichi", "initials": "K"}, {"family": "Shimoda", "given": "Masafumi", "initials": "M"}, {"family": "Osawa", "given": "Takeshi", "initials": "T"}, {"family": "Tateno", "given": "Hiroki", "initials": "H"}, {"family": "Hase", "given": "Isano", "initials": "I"}, {"family": "Yoshida", "given": "Shuichi", "initials": "S"}, {"family": "Suzuki", "given": "Shoji", "initials": "S"}, {"family": "Kawada", "given": "Miki", "initials": "M"}, {"family": "Horinouchi", "given": "Hirohisa", "initials": "H"}, {"family": "Saito", "given": "Fumitake", "initials": "F"}, {"family": "Mitamura", "given": "Keiko", "initials": "K"}, {"family": "Hagihara", "given": "Masao", "initials": "M"}, {"family": "Ochi", "given": "Junichi", "initials": "J"}, {"family": "Uchida", "given": "Tomoyuki", "initials": "T"}, {"family": "Baba", "given": "Rie", "initials": "R"}, {"family": "Arai", "given": "Daisuke", "initials": "D"}, {"family": "Ogura", "given": "Takayuki", "initials": "T"}, {"family": "Takahashi", "given": "Hidenori", "initials": "H"}, {"family": "Hagiwara", "given": "Shigehiro", "initials": "S"}, {"family": "Nagao", "given": "Genta", "initials": "G"}, {"family": "Konishi", "given": "Shunichiro", "initials": "S"}, {"family": "Nakachi", "given": "Ichiro", "initials": "I"}, {"family": "Murakami", "given": "Koji", "initials": "K"}, {"family": "Yamada", "given": "Mitsuhiro", "initials": "M", "orcid": "0000-0002-0832-1939", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d3444abf3314d299e9273003635c06a.json"}}, {"family": "Sugiura", "given": "Hisatoshi", "initials": "H", "orcid": 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"researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34661820735e4853b72794b693577d25.json"}}, {"family": "Ishii", "given": "Makoto", "initials": "M", "orcid": "0000-0003-4396-1664", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/baeffc7d32584e36a16ccd0d1d39aeaa.json"}}, {"family": "Koike", "given": "Ryuji", "initials": "R"}, {"family": "Kitagawa", "given": "Yuko", "initials": "Y"}, {"family": "Kimura", "given": "Akinori", "initials": "A"}, {"family": "Imoto", "given": "Seiya", "initials": "S", "orcid": "0000-0002-2989-308X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f199938ef404db986b6697e05d41d56.json"}}, {"family": "Miyano", "given": "Satoru", "initials": "S"}, {"family": "Ogawa", "given": "Seishi", "initials": "S", "orcid": "0000-0002-7778-5374", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/794485862ba3443294803c120ae16e3a.json"}}, {"family": "Kanai", "given": "Takanori", "initials": "T", "orcid": "0000-0002-1466-4532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c701a687e494d90b9fc18a75a909a28.json"}}, {"family": "Fukunaga", "given": "Koichi", "initials": "K"}, {"family": "Okada", "given": "Yukinori", "initials": "Y", "orcid": "0000-0002-0311-8472", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/180d7682259f44da968366b41662b959.json"}}], "type": "journal article", "published": "2022-08-22", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "4830", "issn-l": "2041-1723"}, "abstract": "Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection.", "doi": "10.1038/s41467-022-32276-2", "pmid": "35995775", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-022-32276-2"}, {"db": "pmc", "key": "PMC9395416"}], "notes": [], "created": "2022-09-12T19:06:01.529Z", "modified": "2022-09-12T19:06:02.312Z"}, {"entity": "publication", "iuid": "ab648c6fe66743d389ec34b288e73dcb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ab648c6fe66743d389ec34b288e73dcb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ab648c6fe66743d389ec34b288e73dcb"}}, "title": "Cross-cultural equivalence of parental ratings of child difficulties during the pandemic: Findings from a six-site study.", "authors": [{"family": "Foley", "given": "Sarah", "initials": "S", "orcid": "0000-0001-8900-9885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2661df30ae94fc296211e848a02a0b9.json"}}, {"family": "Ronchi", "given": "Luca", "initials": "L", "orcid": "0000-0001-7723-9376", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1e89c62c76f443288c1df82f370cdf4.json"}}, {"family": "Lecce", "given": "Serena", "initials": "S", "orcid": "0000-0002-2745-3574", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1fd6450ec02142fb9640a78dcd7c9f83.json"}}, {"family": "Feng", "given": "Xin", "initials": "X", "orcid": "0000-0003-4046-5374", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0a3090940da46f081c5f017dffdea0d.json"}}, {"family": "Chan", "given": "Meingold H M", "initials": "MHM", "orcid": "0000-0001-9108-2504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5d5d31a0104485db02d180a25586206.json"}}, {"family": "Hughes", "given": "Claire", "initials": "C", "orcid": "0000-0003-2545-3025", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7032b296d5145428c9ac304f5a80378.json"}}], "type": "journal article", "published": "2022-08-22", "journal": {"title": "Int J Methods Psychiatr Res", "issn": "1557-0657", "pages": "e1933", "issn-l": null}, "abstract": "The Strengths and Difficulties Questionnaire (SDQ) has been shown to be invariant across informants, developmental stage and settings, but tests of cross-cultural equivalence are limited to adolescents' self-reports. The COVID-19 pandemic makes this gap particularly pertinent, given the need to understand whether distinct government approaches (e.g., school closures) are uniquely associated with variability in children's psychosocial outcomes and the reliance on parents' ratings for young children.\n\nWithin a Confirmatory Factor Analysis framework, we tested the cross-cultural measurement invariance of the SDQ across six countries: Australia, China, Italy, Sweden, the United Kingdom and USA, using a sample of 1761 parents of 3- to 8-year-olds (M = 5.76, SD = 1.09).\n\nA five-factors model showed good fit to the data and partial cross-cultural scalar invariance. In this sample, Swedish parents reported the fewest peer problems (Cohen's d = 0.950) and the highest prosocial scores (Cohen's d = 0.547), whilst British parents reported the greatest child emotional (Cohen's d = 0.412) and hyperactivity problems (Cohen's d = 0.535).\n\nThe present results indicate that the parent-version of the SDQ is appropriate for use and comparison across different contexts during the pandemic.", "doi": "10.1002/mpr.1933", "pmid": "35994374", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:59:43.015Z", "modified": "2022-09-12T18:59:43.208Z"}, {"entity": "publication", "iuid": "239a6b95cd38479fb8bf23f47400d393", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/239a6b95cd38479fb8bf23f47400d393.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/239a6b95cd38479fb8bf23f47400d393"}}, "title": "COVID-19 Modeling Outcome versus Reality in Sweden.", "authors": [{"family": "Carlsson", "given": "Marcus", "initials": "M", "orcid": "0000-0002-3761-9072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9492f80f98584a4c949a0114fb44ef71.json"}}, {"family": "S\u00f6derberg-Naucl\u00e9r", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-8955-3610", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f10026ba9a64bfea2fc49de969cdde9.json"}}], "type": "journal article", "published": "2022-08-22", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "8", "issn-l": "1999-4915"}, "abstract": "It has been very difficult to predict the development of the COVID-19 pandemic based on mathematical models for the spread of infectious diseases, and due to major non-pharmacological interventions (NPIs), it is still unclear to what extent the models would have fit reality in a \"do nothing\" scenario. To shed light on this question, the case of Sweden during the time frame from autumn 2020 to spring 2021 is particularly interesting, since the NPIs were relatively minor and only marginally updated. We found that state of the art models are significantly overestimating the spread, unless we assume that social interactions significantly decrease continuously throughout the time frame, in a way that does not correlate well with Google-mobility data nor updates to the NPIs or public holidays. This leads to the question of whether modern SEIR-type mathematical models are unsuitable for modeling the spread of SARS-CoV-2 in the human population, or whether some particular feature of SARS-CoV-2 dampened the spread. We show that, by assuming a certain level of pre-immunity to SARS-CoV-2, we obtain an almost perfect data-fit, and discuss what factors could cause pre-immunity in the mathematical models. In this scenario, a form of herd-immunity under the given restrictions was reached twice (first against the Wuhan-strain and then against the alpha-strain), and the ultimate decline in cases was due to depletion of susceptibles rather than the vaccination campaign.", "doi": "10.3390/v14081840", "pmid": "36016462", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9415753"}, {"db": "pii", "key": "v14081840"}], "notes": [], "created": "2022-09-12T19:14:03.232Z", "modified": "2023-07-13T11:29:53.833Z"}, {"entity": "publication", "iuid": "b6de4fc9b0434827b7ca222118639d0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b6de4fc9b0434827b7ca222118639d0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b6de4fc9b0434827b7ca222118639d0e"}}, "title": "Response to Frequency of new seizures after SARS-CoV-2 infections may depend on the length of follow-up.", "authors": [{"family": "Westman", "given": "Gabriel", "initials": "G"}, {"family": "Zelano", "given": "Johan", "initials": "J"}], "type": "letter", "published": "2022-08-20", "journal": {"title": "Seizure", "issn": "1532-2688", "issn-l": null}, "abstract": null, "doi": "10.1016/j.seizure.2022.08.006", "pmid": "36030113", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1059-1311(22)00185-6"}, {"db": "pmc", "key": "PMC9391083"}], "notes": [], "created": "2022-10-07T12:40:23.381Z", "modified": "2022-10-07T12:40:23.397Z"}, {"entity": "publication", "iuid": "1091fb0317e6482fa445eb910829a150", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1091fb0317e6482fa445eb910829a150.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1091fb0317e6482fa445eb910829a150"}}, "title": "Comparison of SARS-CoV-2 spike RNA sequences in feces and nasopharynx indicates intestinal replication.", "authors": [{"family": "Beck-Friis", "given": "Thomas", "initials": "T"}, {"family": "K\u00e4rmander", "given": "Ambj\u00f6rn", "initials": "A"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Wang", "given": "Hao", "initials": "H"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Norder", "given": "Hel\u00e9ne", "initials": "H"}], "type": "journal article", "published": "2022-08-20", "journal": {"title": "Gut Pathog", "issn": "1757-4749", "volume": "14", "issue": "1", "pages": "35", "issn-l": null}, "abstract": "Little is known of possible selection and replication of SARS-CoV-2 in the intestines and if viral load in feces is associated with severity of disease. Therefore, sequence variations of the spike region in strains collected from feces and nasopharynx (NPH) from the same patients were compared. It was also investigated whether viral load in feces related to severity of COVID-19 in hospitalized patients.\n\nSARS-CoV-2 RNA was found in 88 (79%) fecal samples from 112 patients. The complete spike region could be sequenced in 15 fecal and 14 NPH samples. Fourteen Alpha-variants and one Beta-variant of SARS-CoV-2 were identified. The majority of the viral genetic variants (viral populations) in two fecal samples, but none in NPH, had a reversion of the H69/V70 amino acid deletion normally seen in the Alpha variants. Nine fecal samples contained up to nine minority variants, each which may constitute a separate viral population. Five NPH samples had one genetic variant each, and one NPH sample contained nine minority populations of SARS-CoV-2 spike genes.\n\nThe higher genomic diversity of SARS-CoV-2 in feces compared to NPH, and the reversion of the H69/V70 deletion in Alpha variants from feces indicate a selection of viral strains and replication of SARS-CoV-2 in the gastrointestinal tract.", "doi": "10.1186/s13099-022-00509-w", "pmid": "35987708", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13099-022-00509-w"}, {"db": "pmc", "key": "PMC9392503"}], "notes": [], "created": "2022-09-12T18:48:29.511Z", "modified": "2022-09-12T18:48:29.537Z"}, {"entity": "publication", "iuid": "1fa3baf6ba384548a6d4e9676212cd2b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1fa3baf6ba384548a6d4e9676212cd2b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1fa3baf6ba384548a6d4e9676212cd2b"}}, "title": "COVID-19 and Politically Motivated Reasoning.", "authors": [{"family": "Maguire", "given": "Allegra", "initials": "A"}, {"family": "Persson", "given": "Emil", "initials": "E", "orcid": "0000-0003-2994-0541", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5722c7a43dbc4303859f72218a6739da.json"}}, {"family": "V\u00e4stfj\u00e4ll", "given": "Daniel", "initials": "D"}, {"family": "Tingh\u00f6g", "given": "Gustav", "initials": "G", "orcid": "0000-0002-8159-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c4dcebfe7b0425182298cf35259223c.json"}}], "type": "journal article", "published": "2022-08-20", "journal": {"title": "Med Decis Making", "issn": "1552-681X", "issn-l": null, "volume": null, "issue": null, "pages": "272989X221118078"}, "abstract": "During the COVID-19 pandemic, the world witnessed a partisan segregation of beliefs toward the global health crisis and its management. Politically motivated reasoning, the tendency to interpret information in accordance with individual motives to protect valued beliefs rather than objectively considering the facts, could represent a key process involved in the polarization of attitudes. The objective of this study was to explore politically motivated reasoning when participants assess information regarding COVID-19.\r\n\r\nWe carried out a preregistered online experiment using a diverse sample (N = 1500) from the United States. Both Republicans and Democrats assessed the same COVID-19-related information about the health effects of lockdowns, social distancing, vaccination, hydroxychloroquine, and wearing face masks.\r\n\r\nAt odds with our prestated hypothesis, we found no evidence in line with politically motivated reasoning when interpreting numerical information about COVID-19. Moreover, we found no evidence supporting the idea that numeric ability or cognitive sophistication bolster politically motivated reasoning in the case of COVID-19. Instead, our findings suggest that participants base their assessment on prior beliefs of the matter.\r\n\r\nOur findings suggest that politically polarized attitudes toward COVID-19 are more likely to be driven by lack of reasoning than politically motivated reasoning-a finding that opens potential avenues for combating political polarization about important health care topics.\r\n\r\nParticipants assessed numerical information regarding the effect of different COVID-19 policies.We found no evidence in line with politically motivated reasoning when interpreting numerical information about COVID-19.Participants tend to base their assessment of COVID-19-related facts on prior beliefs of the matter.Politically polarized attitudes toward COVID-19 are more a result of lack of thinking than partisanship.", "doi": "10.1177/0272989X221118078", "pmid": "35993415", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:53:25.098Z", "modified": "2022-11-09T08:37:33.249Z"}, {"entity": "publication", "iuid": "673f5eb1917b413d908fd5821b9cf280", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/673f5eb1917b413d908fd5821b9cf280.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/673f5eb1917b413d908fd5821b9cf280"}}, "title": "Pulmonary Embolism in Post-CoviD-19 Patients, a Literature Review: Red Flag for Increased Awareness?", "authors": [{"family": "Mouzarou", "given": "Angeliki", "initials": "A", "orcid": "0000-0002-6687-5075", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07a30f36479e44bc937fa4bd97026313.json"}}, {"family": "Ioannou", "given": "Maria", "initials": "M"}, {"family": "Leonidou", "given": "Elena", "initials": "E"}, {"family": "Chaziri", "given": "Ioanna", "initials": "I"}], "type": "journal article", "published": "2022-08-19", "journal": {"title": "SN Compr Clin Med", "issn": "2523-8973", "volume": "4", "issue": "1", "pages": "190", "issn-l": null}, "abstract": "Although COVID-19 was primarily considered a respiratory illness, rapidly accumulating data suggest that COVID-19 is associated with a high incidence of venous thromboembolic complications. The primary objective of this review article was to reveal whether we need to increase awareness of pulmonary embolism in the period following the COVID-19 infection given that the epidemiologic facts are still poor. A literature search and a critical review of the collected studies were conducted. An electronic search of PubMed, Science Direct Scopus, Google Scholar, and Excerpta Medica Database (EMBASE) from June 2020 until June 2022. The long-term health consequences of COVID-19 remain largely unclear. This review highlights the importance of awareness of the potentially increased incidence of venous thromboembolism in post-COVID-19 patients, even those with mild or asymptomatic disease. Further research is required to establish appropriate clinical management guidelines for the prevention of thromboembolic complications in the post-COVID-19 period.", "doi": "10.1007/s42399-022-01273-3", "pmid": "35999860", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "1273"}, {"db": "pmc", "key": "PMC9389494"}], "notes": [], "created": "2022-08-26T04:44:27.340Z", "modified": "2022-08-26T04:44:27.396Z"}, {"entity": "publication", "iuid": "3ca706b10da844938e6670e29373f1c8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ca706b10da844938e6670e29373f1c8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ca706b10da844938e6670e29373f1c8"}}, "title": "Global Prevalence and Potential Influencing Factors of COVID-19 Vaccination Hesitancy: A Meta-Analysis.", "authors": [{"family": "Fajar", "given": "Jonny Karunia", "initials": "JK", "orcid": "0000-0002-0309-5813", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5fb04d101ce4d20a4cb8692bbd67659.json"}}, {"family": "Sallam", "given": "Malik", "initials": "M", "orcid": "0000-0002-0165-9670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb490d3ed32f4b76b8a39bd0320bd748.json"}}, {"family": "Soegiarto", "given": "Gatot", "initials": "G", "orcid": "0000-0002-9197-3873", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ead7821cabe648c6a2c0ec9596015f55.json"}}, {"family": "Sugiri", "given": "Yani Jane", "initials": "YJ"}, {"family": "Anshory", "given": "Muhammad", "initials": "M"}, {"family": "Wulandari", "given": "Laksmi", "initials": "L"}, {"family": "Kosasih", "given": "Stephanie Astrid Puspitasari", "initials": "SAP"}, {"family": "Ilmawan", "given": "Muhammad", "initials": "M"}, {"family": "Kusnaeni", "given": "Kusnaeni", "initials": "K"}, {"family": "Fikri", "given": "Muhammad", "initials": "M"}, {"family": "Putri", "given": "Frilianty", "initials": "F"}, {"family": "Hamdi", "given": "Baitul", "initials": "B"}, {"family": "Pranatasari", "given": "Izza Dinalhaque", "initials": "ID"}, {"family": "Aina", "given": "Lily", "initials": "L", "orcid": "0000-0002-3083-9507", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9fe14a514c9c4768a81272f1dd18e10d.json"}}, {"family": "Maghfiroh", "given": "Lailatul", "initials": "L", "orcid": "0000-0002-6923-3887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9869ffbdd0924f06aef5a9f343c342a6.json"}}, {"family": "Ikhriandanti", "given": "Fernanda Septi", "initials": "FS"}, {"family": "Endiaverni", "given": "Wa Ode", "initials": "WO"}, {"family": "Nugraha", "given": "Krisna Wahyu", "initials": "KW", "orcid": "0000-0001-9188-0346", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8909f02dd3c24e258843c32ea5e903d4.json"}}, {"family": "Wiranudirja", "given": "Ory", "initials": "O"}, {"family": "Edinov", "given": "Sally", "initials": "S"}, {"family": "Hamdani", "given": "Ujang", "initials": "U", "orcid": "0000-0001-8867-0030", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ccfb26ce87148e899456efcec7caea9.json"}}, {"family": "Rosyidah", "given": "Lathifatul", "initials": "L"}, {"family": "Lubaba", "given": "Hanny", "initials": "H"}, {"family": "Ariwibowo", "given": "Rinto", "initials": "R"}, {"family": "Andistyani", "given": "Riska", "initials": "R"}, {"family": "Fitriani", "given": "Ria", "initials": "R"}, {"family": "Hasanah", "given": "Miftahul", "initials": "M"}, {"family": "Nafis", "given": "Fardha Ad Durrun", "initials": "FAD"}, {"family": "Tamara", "given": "Fredo", "initials": "F"}, {"family": "Latamu", "given": "Fitri Olga", "initials": "FO"}, {"family": "Kusuma", "given": "Hendrix Indra", "initials": "HI", "orcid": "0000-0003-3555-0136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d3daa17c23742d0ba36d8dad2d7be79.json"}}, {"family": "Rabaan", "given": "Ali A", "initials": "AA", "orcid": "0000-0002-6774-9847", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6f7d6e2db1e34c19ab20d96af6cf384d.json"}}, {"family": "Alhumaid", "given": "Saad", "initials": "S", "orcid": "0000-0003-4552-4513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5b42c928b1a4d75840ad62b355d06f7.json"}}, {"family": "Mutair", "given": "Abbas Al", "initials": "AA"}, {"family": "Garout", "given": "Mohammed", "initials": "M"}, {"family": "Halwani", "given": "Muhammad A", "initials": "MA"}, {"family": "Alfaresi", "given": "Mubarak", "initials": "M", "orcid": "0000-0003-2523-835X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9115c5a248448748bc57159a479f0e8.json"}}, {"family": "Al Azmi", "given": "Reyouf", "initials": "R"}, {"family": "Alasiri", "given": "Nada A", "initials": "NA", "orcid": "0000-0003-2549-9904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1068b2b4acd46988f349835bda1eccf.json"}}, {"family": "Alshukairi", "given": "Abeer N", "initials": "AN"}, {"family": "Dhama", "given": "Kuldeep", "initials": "K", "orcid": "0000-0001-7469-4752", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef8824b2d5dc494ca3c21dc5e783e677.json"}}, {"family": "Harapan", "given": "Harapan", "initials": "H", "orcid": "0000-0001-7630-8413", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06f2d40c26be48cd8ba815701674b0f1.json"}}], "type": "journal article", "published": "2022-08-19", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "Countries worldwide have deployed mass COVID-19 vaccination drives, but there are people who are hesitant to receive the vaccine. Studies assessing the factors associated with COVID-19 vaccination hesitancy are inconclusive. This study aimed to assess the global prevalence of COVID-19 vaccination hesitancy and determine the potential factors associated with such hesitancy. We performed an organized search for relevant articles in PubMed, Scopus, and Web of Science. Extraction of the required information was performed for each study. A single-arm meta-analysis was performed to determine the global prevalence of COVID-19 vaccination hesitancy; the potential factors related to vaccine hesitancy were analyzed using a Z-test. A total of 56 articles were included in our analysis. We found that the global prevalence of COVID-19 vaccination hesitancy was 25%. Being a woman, being a 50-year-old or younger, being single, being unemployed, living in a household with five or more individuals, having an educational attainment lower than an undergraduate degree, having a non-healthcare-related job and considering COVID-19 vaccines to be unsafe were associated with a higher risk of vaccination hesitancy. In contrast, living with children at home, maintaining physical distancing norms, having ever tested for COVID-19, and having a history of influenza vaccination in the past few years were associated with a lower risk of hesitancy to COVID-19 vaccination. Our study provides valuable information on COVID-19 vaccination hesitancy, and we recommend special interventions in the sub-populations with increased risk to reduce COVID-19 vaccine hesitancy.", "doi": "10.3390/vaccines10081356", "pmid": "36016242", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "vaccines10081356"}, {"db": "pmc", "key": "PMC9412456"}], "notes": [], "created": "2022-09-12T19:13:23.853Z", "modified": "2022-09-12T19:13:46.052Z"}, {"entity": "publication", "iuid": "38520aadc94b49758014b1674c74bf4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38520aadc94b49758014b1674c74bf4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38520aadc94b49758014b1674c74bf4d"}}, "title": "Complement C3 inhibition in severe COVID-19 using compstatin AMY-101.", "authors": [{"family": "Skendros", "given": "Panagiotis", "initials": "P", "orcid": "0000-0003-0456-7015", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f3964bd31a644fb9edb3ddb8012d6ae.json"}}, {"family": "Germanidis", "given": "Georgios", "initials": "G", "orcid": "0000-0001-7985-3118", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b064677471a4dfca38ef7e09409822e.json"}}, {"family": "Mastellos", "given": "Dimitrios C", "initials": "DC", "orcid": "0000-0002-6634-3271", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a842782e093409fa426e83d3ef99663.json"}}, {"family": "Antoniadou", "given": "Christina", "initials": "C", "orcid": "0000-0001-7391-6851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c51d5f05105f49ea9303e95bd81cc91e.json"}}, {"family": "Gavriilidis", "given": "Efstratios", "initials": "E", "orcid": "0000-0002-1591-9760", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a54d5da4ddd49f9b478dcb93bc9205f.json"}}, {"family": "Kalopitas", "given": "Georgios", "initials": "G", "orcid": "0000-0002-4962-790X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ec02ed547494cd4a5648a76204675d2.json"}}, {"family": "Samakidou", "given": "Anna", "initials": "A"}, {"family": "Liontos", "given": "Angelos", "initials": "A", "orcid": "0000-0002-0361-0846", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70560431d93d43e2a48579c019d7fcad.json"}}, {"family": "Chrysanthopoulou", "given": "Akrivi", "initials": "A"}, {"family": "Ntinopoulou", "given": "Maria", "initials": "M"}, {"family": "Kogias", "given": "Dionysios", "initials": "D", "orcid": "0000-0002-2505-7076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7914e0d4d3d64f18855f716e8f7f2910.json"}}, {"family": "Karanika", "given": "Ioanna", "initials": "I"}, {"family": "Smyrlis", "given": "Andreas", "initials": "A", "orcid": "0000-0002-3964-5944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9948578678704ba99655ee7d8eecda93.json"}}, {"family": "Cepaityte", "given": "Dainora", "initials": "D", "orcid": "0000-0003-2652-4120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f9344cdf81d4d1293b919741dd63a6e.json"}}, {"family": "Fotiadou", "given": "Iliana", "initials": "I", "orcid": "0000-0002-7618-4243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa2fc15ebd174048a197345093f8a2e5.json"}}, {"family": "Zioga", "given": "Nikoleta", "initials": "N", "orcid": "0000-0002-8614-6742", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed19a1127a244e4891d8460adf6f93c4.json"}}, {"family": "Mitroulis", "given": "Ioannis", "initials": "I"}, {"family": "Gatselis", "given": "Nikolaos K", "initials": "NK", "orcid": "0000-0002-3715-8640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48a938526b5c4b14bd32e1f0dd90b6f8.json"}}, {"family": "Papagoras", "given": "Charalampos", "initials": "C", "orcid": "0000-0001-6207-496X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1ed3220f27c4dd4bcd76135200ebb4c.json"}}, {"family": "Metallidis", "given": "Simeon", "initials": "S"}, {"family": "Milionis", "given": "Haralampos", "initials": "H", "orcid": "0000-0003-3958-2266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d08064024f26409a98b57a024329787a.json"}}, {"family": "Dalekos", "given": "George N", "initials": "GN", "orcid": "0000-0001-7075-8464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4c60cecbf7d4316b5a2e64267ec7925.json"}}, {"family": "Willems", "given": "Loek", "initials": "L"}, {"family": "Persson", "given": "Barbro", "initials": "B"}, {"family": "Manivel", "given": "Vivek Anand", "initials": "VA", "orcid": "0000-0002-6746-7372", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c45a913d5fdc4446987103f9519cf28f.json"}}, {"family": "Nilsson", "given": "Bo", "initials": "B"}, {"family": "Connolly", "given": "E Sander", "initials": "ES"}, {"family": "Iacobelli", "given": "Simona", "initials": "S"}, {"family": "Papadopoulos", "given": "Vasileios", "initials": "V", "orcid": "0000-0002-4188-9518", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6576628a0472453499d211ea786bdc89.json"}}, {"family": "Calado", "given": "Rodrigo T", "initials": "RT", "orcid": "0000-0002-7966-6029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9cc3032ec8444cf69e4bd24bbc1a1c79.json"}}, {"family": "Huber-Lang", "given": "Markus", "initials": "M", "orcid": "0000-0003-2359-6516", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d93a6fbd9f6446f58a91c65078b4dec0.json"}}, {"family": "Risitano", "given": "Antonio M", "initials": "AM"}, {"family": "Yancopoulou", "given": "Despina", "initials": "D"}, {"family": "Ritis", "given": "Konstantinos", "initials": "K"}, {"family": "Lambris", "given": "John D", "initials": "JD", "orcid": "0000-0002-9370-5776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3feb5c64951b4305b97bcffa49e6154a.json"}}], "type": "journal article", "published": "2022-08-19", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "8", "issue": "33", "pages": "eabo2341", "issn-l": "2375-2548"}, "abstract": "Complement C3 activation contributes to COVID-19 pathology, and C3 targeting has emerged as a promising therapeutic strategy. We provide interim data from ITHACA, the first randomized trial evaluating a C3 inhibitor, AMY-101, in severe COVID-19 (PaO2/FiO2 \u2264 300 mmHg). Patients received AMY-101 (n = 16) or placebo (n = 15) in addition to standard of care. AMY-101 was safe and well tolerated. Compared to placebo (8 of 15, 53.3%), a higher, albeit nonsignificant, proportion of AMY-101-treated patients (13 of 16, 81.3%) were free of supplemental oxygen at day 14. Three nonresponders and two placebo-treated patients succumbed to disease-related complications. AMY-101 significantly reduced CRP and ferritin and restrained thrombin and NET generation. Complete and sustained C3 inhibition was observed in all responders. Residual C3 activity in the three nonresponders suggested the presence of a convertase-independent C3 activation pathway overriding the drug's inhibitory activity. These findings support the design of larger trials exploring the potential of C3-based inhibition in COVID-19 or other complement-mediated diseases.", "doi": "10.1126/sciadv.abo2341", "pmid": "35977025", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9385148"}], "notes": [], "created": "2022-09-12T18:39:40.359Z", "modified": "2022-09-12T18:39:41.017Z"}, {"entity": "publication", "iuid": "1a68a79d4505455ab7cb857cd82eafca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1a68a79d4505455ab7cb857cd82eafca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1a68a79d4505455ab7cb857cd82eafca"}}, "title": "Acute Kidney Injury in COVID-19 Patients: Pathogenesis, Clinical Characteristics, Therapy, and Mortality.", "authors": [{"family": "Ch\u00e1vez-Valencia", "given": "Venice", "initials": "V"}, {"family": "Orizaga-de-la-Cruz", "given": "Citlalli", "initials": "C"}, {"family": "Lagunas-Rangel", "given": "Francisco Alejandro", "initials": "FA", "orcid": "0000-0001-7730-6452", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/737bd8eaf59a4ae28b71f4270c1f56c3.json"}}], "type": "journal article", "published": "2022-08-19", "journal": {"title": "Diseases", "issn": "2079-9721", "volume": "10", "issue": "3", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) is a disease caused by infection with the SARS-CoV-2 virus and has represented one of the greatest challenges humanity has faced in recent years. The virus can infect a large number of organs, including the lungs and upper respiratory tract, brain, liver, kidneys, and intestines, among many others. Although the greatest damage occurs in the lungs, the kidneys are not exempt, and acute kidney injury (AKI) can occur in patients with COVID-19. Indeed, AKI is one of the most frequent and serious organic complications of COVID-19. The incidence of COVID-19 AKI varies widely, and the exact mechanisms of how the virus damages the kidney are still unknown. For this reason, the purpose of this review was to assess current findings on the pathogenesis, clinical features, therapy, and mortality of COVID-19 AKI.", "doi": "10.3390/diseases10030053", "pmid": "35997358", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "diseases10030053"}], "notes": [], "created": "2022-08-26T04:45:32.548Z", "modified": "2022-08-26T04:45:32.621Z"}, {"entity": "publication", "iuid": "e71abb03bfb741cbb5c70008a6c0cd26", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e71abb03bfb741cbb5c70008a6c0cd26.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e71abb03bfb741cbb5c70008a6c0cd26"}}, "title": "A universal SARS-CoV DNA vaccine inducing highly cross-reactive neutralizing antibodies and T cells.", "authors": [{"family": "Appelberg", "given": "Sofia", "initials": "S", "orcid": "0000-0002-7381-3606", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a3e2ab8513742af91714b79b472734a.json"}}, {"family": "Ahl\u00e9n", "given": "Gustaf", "initials": "G", "orcid": "0000-0002-2681-6433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eda17940966a4e059f1598116f8572bf.json"}}, {"family": "Yan", "given": "Jingyi", "initials": "J", "orcid": "0000-0002-2266-7338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/071873148bdc4d588d050516bc7d44b0.json"}}, {"family": "Nikouyan", "given": "Negin", "initials": "N", "orcid": "0000-0003-3588-2448", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fefca010183442c093b01849a08149c6.json"}}, {"family": "Weber", "given": "Sofie", "initials": "S"}, {"family": "Larsson", "given": "Olivia", "initials": "O"}, {"family": "H\u00f6glund", "given": "Urban", "initials": "U"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Weber", "given": "Friedemann", "initials": "F", "orcid": "0000-0001-9737-337X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cfac6ca689c5467396ede57ba57092da.json"}}, {"family": "Perlhamre", "given": "Emma", "initials": "E"}, {"family": "Apro", "given": "Johanna", "initials": "J"}, {"family": "Gidlund", "given": "Eva-Karin", "initials": "E"}, {"family": "Tuvesson", "given": "Ola", "initials": "O", "orcid": "0000-0003-2232-026X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/99b2a259824c4a7abac326481f01bc28.json"}}, {"family": "Salati", "given": "Simona", "initials": "S", "orcid": "0000-0002-8072-1128", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd374f0c8bc34c028ba321a68aa4b85e.json"}}, {"family": "Cadossi", "given": "Matteo", "initials": "M"}, {"family": "Tegel", "given": "Hanna", "initials": "H", "orcid": "0000-0002-7067-9173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d3fde7ee5de4dab899746becfae364d.json"}}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Frelin", "given": "Lars", "initials": "L", "orcid": "0000-0001-7452-1667", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd26ddedec244820a9a1e19f76cc5cf8.json"}}, {"family": "Mirazimi", "given": "Ali", "initials": "A", "orcid": "0000-0003-2371-6055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0651be47429c4e5880a13b839d04fe1d.json"}}, {"family": "S\u00e4llberg", "given": "Matti", "initials": "M", "orcid": "0000-0002-8858-5132", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ef589af054b4f94a635ce4021d19ed6.json"}}], "type": "journal article", "published": "2022-08-19", "journal": {"title": "EMBO Mol Med", "issn": "1757-4684", "issn-l": "1757-4676", "volume": null, "issue": null, "pages": "e15821"}, "abstract": "New variants in the SARS-CoV-2 pandemic are more contagious (Alpha/Delta), evade neutralizing antibodies (Beta), or both (Omicron). This poses a challenge in vaccine development according to WHO. We designed a more universal SARS-CoV-2 DNA vaccine containing receptor-binding domain loops from the huCoV-19/WH01, the Alpha, and the Beta variants, combined with the membrane and nucleoproteins. The vaccine induced spike antibodies crossreactive between huCoV-19/WH01, Beta, and Delta spike proteins that neutralized huCoV-19/WH01, Beta, Delta, and Omicron virus in vitro. The vaccine primed nucleoprotein-specific T cells, unlike spike-specific T cells, recognized Bat-CoV sequences. The vaccine protected mice carrying the human ACE2 receptor against lethal infection with the SARS-CoV-2 Beta variant. Interestingly, priming of cross-reactive nucleoprotein-specific T cells alone was 60% protective, verifying observations from humans that T cells protect against lethal disease. This SARS-CoV vaccine induces a uniquely broad and functional immunity that adds to currently used vaccines.", "doi": "10.15252/emmm.202215821", "pmid": "35986481", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:46:48.046Z", "modified": "2022-09-12T18:47:48.444Z"}, {"entity": "publication", "iuid": "5cd512c8ebc74a6aab9caeb6f2afed41", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5cd512c8ebc74a6aab9caeb6f2afed41.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5cd512c8ebc74a6aab9caeb6f2afed41"}}, "title": "Trends in upper respiratory tract infections and antibiotic prescriptions during the COVID-19 pandemic - a national observational study.", "authors": [{"family": "Gisselsson-Solen", "given": "Marie", "initials": "M", "orcid": "0000-0003-2802-2343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef722726120a4d26ad687988eb841f80.json"}}, {"family": "Hermansson", "given": "Ann", "initials": "A"}], "type": "editorial", "published": "2022-08-18", "journal": {"title": "Acta Otolaryngol", "issn": "1651-2251", "pages": "1-4", "issn-l": "0001-6489"}, "abstract": null, "doi": "10.1080/00016489.2022.2109727", "pmid": "35980331", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:43:07.012Z", "modified": "2022-09-12T18:43:07.066Z"}, {"entity": "publication", "iuid": "76b43f698f12496a8052cbbfcdc0ddfe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76b43f698f12496a8052cbbfcdc0ddfe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76b43f698f12496a8052cbbfcdc0ddfe"}}, "title": "Selective Serotonin Reuptake Inhibitors may Influence COVID-19 Prognosis through Antioxidant and Cytoprotective Pathways Mediated by Sigma 1 Receptor Agonism.", "authors": [{"family": "Papadopoulos", "given": "Konstantinos I", "initials": "KI", "orcid": "0000-0003-0041-7853", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/57c63fdf7036465686e79794a5107544.json"}}, {"family": "Papadopoulou", "given": "Alexandra", "initials": "A", "orcid": "0000-0002-7488-8271", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9000ff7673bc4d35bde729ce8829ab5d.json"}}, {"family": "Aw", "given": "Tar-Choon", "initials": "TC", "orcid": "0000-0002-7814-8836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f95d6a8535d41fbb7b5cf40fb091205.json"}}], "type": "journal article", "published": "2022-08-18", "journal": {"title": "Pharmacopsychiatry", "issn": "1439-0795", "issn-l": null}, "abstract": null, "doi": "10.1055/a-1909-2198", "pmid": "35981550", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:45:06.412Z", "modified": "2022-09-12T18:45:22.624Z"}, {"entity": "publication", "iuid": "16a3ca6332634a2791bbb8a73799d0af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16a3ca6332634a2791bbb8a73799d0af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16a3ca6332634a2791bbb8a73799d0af"}}, "title": "An interrupted time series analysis of gambling behavior based on gambling operator revenue-based taxation during the COVID-19 pandemic in Sweden.", "authors": [{"family": "Andersson", "given": "M J", "initials": "MJ"}, {"family": "Balem", "given": "M", "initials": "M"}, {"family": "H\u00e5kansson", "given": "A", "initials": "A"}], "type": "journal article", "published": "2022-08-18", "journal": {"title": "Public Health", "issn": "1476-5616", "volume": "211", "pages": "14-20", "issn-l": null}, "abstract": "The impact of COVID-19 on gambling behavior and the gambling industry itself has been widely speculated. Prior studies have shown how boredom, social isolation, poor mental health, and financial hardships, all of which have been associated with COVID-19, can aggravate problem gambling behaviors in patients with gambling disorders while also luring newcomers. Few studies have used methods other than self-report to assess longitudinal behavioral changes in gambling behavior before versus during the pandemic.\n\nThe present study addresses this gap by using an interrupted time series approach on data obtained from the Swedish Gambling Authority measuring taxation on gambling vendors' revenue between January 2019 and November 2021.\n\nMarch, June, and October 2020 were chosen as interruption points as they correspond to the pandemic's commencement, the return of elite sports, and the second wave of cases in Sweden, respectively. We hypothesized that the pandemic would be associated with both temporary changes for select gambling types and long-term increases in online gambling.\n\nResults revealed the pandemic's onset was associated with transient effects at each point of interruption, as well as long-term upward trends in total gambling and commercial online gambling, excluding horse betting and the state-owned operator for online casinos and betting.\n\nThe present study's findings, although consistent with the theory that gambling activity could increase during the pandemic, contradict previous studies that found no changes or a decrease from pre-COVID-19 levels. Findings indicate that the pandemic and Sweden's reaction to it were associated with increased use of some gambling products.", "doi": "10.1016/j.puhe.2022.07.003", "pmid": "35988505", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0033-3506(22)00198-6"}], "notes": [], "created": "2022-09-12T18:49:20.251Z", "modified": "2022-09-12T18:49:20.257Z"}, {"entity": "publication", "iuid": "6b199a2fa90e431687b033fc4dc3f90f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b199a2fa90e431687b033fc4dc3f90f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b199a2fa90e431687b033fc4dc3f90f"}}, "title": "Patient lead users experience of the COVID-19 pandemic: a qualitative interview study.", "authors": [{"family": "Jansson", "given": "Hanna", "initials": "H", "orcid": "0000-0002-1615-0463", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88337ae732344b7fb3ebc5a04ef9894b.json"}}, {"family": "Stenfors", "given": "Terese", "initials": "T", "orcid": "0000-0002-0854-8631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/785692870b584906b79702cbfdac8866.json"}}, {"family": "Riggare", "given": "Sara", "initials": "S", "orcid": "0000-0002-2256-7310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ffa9b36c39043578cfa21a881699ea7.json"}}, {"family": "Hasson", "given": "Henna", "initials": "H", "orcid": "0000-0002-3827-6841", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1c2ba4af37b4c678656ea948b76fa93.json"}}, {"family": "Reinius", "given": "Maria", "initials": "M", "orcid": "0000-0003-0864-8701", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8dc0b4c1305b49349adfb8f4da310856.json"}}], "type": "journal article", "published": "2022-08-17", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "8", "pages": "e059003", "issn-l": "2044-6055"}, "abstract": "Patient lead users can be defined as patients or relatives who use their knowledge and experience to improve their own or a relative's care situation and/or the healthcare system, and who are active beyond what is usually expected. The objective of this study is to explore patient lead users' experiences and engagement during the early COVID-19 pandemic.\n\nQualitative in-depth interviews with a cross-sectional time horizon.\n\nThe early COVID-19 pandemic in Sweden, from 1 June through 14 September, 2020.\n\nA total of 10 patient lead users were recruited from the Swedish patient lead users (spetspatient) network. All participants were living with different long-term conditions and matched the definition of being patient lead users.\n\nWe found that during the early pandemic, patient lead users experienced that they no longer knew how to best manage their own health and care situations. On an individual level, they described an initial lack of knowledge, new routines, including a change in their health and an experience of people without a disease being in the same situation as them, for a while. On a systemic level, they described a fear of imminent unmet-care backlogs and decreased opportunities for sharing patient perspectives in care organisation, but also described increased networking.\n\nPatient lead users can be seen as an emerging community of practice, and as such could be a valuable resource as a complementary communication channel for an improved health system. The health systems were not able to fully acknowledge and engage with the resource of patient lead users during the pandemic.", "doi": "10.1136/bmjopen-2021-059003", "pmid": "35977768", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-059003"}, {"db": "pmc", "key": "PMC9388713"}], "notes": [], "created": "2022-09-12T18:40:01.486Z", "modified": "2022-09-12T18:40:01.671Z"}, {"entity": "publication", "iuid": "6d6ea640ecfb4b2e89afbd38ac585f69", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6d6ea640ecfb4b2e89afbd38ac585f69.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6d6ea640ecfb4b2e89afbd38ac585f69"}}, "title": "How much are we worth? Experiences of nursing assistants in Swedish nursing homes during the first wave of COVID-19.", "authors": [{"family": "Bergqvist", "given": "Monica", "initials": "M", "orcid": "0000-0002-3061-4885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/024ed86bac7d4d64a4073057c79f05e1.json"}}, {"family": "Bastholm-Rahmner", "given": "Pia", "initials": "P"}, {"family": "Gustafsson", "given": "Lars L", "initials": "LL"}, {"family": "Holmgren", "given": "Katarina", "initials": "K"}, {"family": "Veg", "given": "Anik\u00f3", "initials": "A"}, {"family": "Wachtler", "given": "Caroline", "initials": "C"}, {"family": "Schmidt-Mende", "given": "Katharina", "initials": "K"}], "type": "journal article", "published": "2022-08-17", "journal": {"title": "Int J Older People Nurs", "issn": "1748-3743", "pages": "e12498", "issn-l": null}, "abstract": "NHs have been severely exposed during the COVID-19 pandemic. Little is known about how staff who provide practical daily care of older residents experienced work during the pandemic. The aim of this study was to understand how nursing assistants (NAs) experienced their work at nursing homes (NHs) for older people during the first wave of the COVID-19 pandemic.\n\nWe conducted a qualitative study of focus group discussions with in total 20 participants from four NHs in Stockholm, Sweden. Discussions were held in November 2020. Transcripts were analyzed using inductive thematic analysis.\n\nWe identified three major themes: 1) We felt abandoned, scared and disrespected, 2) We made sure we made it through, and 3) We can do good work with appropriate resources. NAs felt disregarded as they were often left alone without adequate support from managers, registered nurses and the municipalities. NAs felt distressed and guilty and developed their own strategies to cope and manage their work.\n\nDuring the first wave of the COVID-19 pandemic NAs felt abandoned and burdened due to lack of leadership. Organizational improvements are required to protect the wellbeing of NAs and to ensure sustainability of patient safety. NAs are crucial in the care for vulnerable older people and their experiences should constitute a keystone for development of future policy and practice in NHs.", "doi": "10.1111/opn.12498", "pmid": "35978489", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-09-12T18:41:01.840Z", "modified": "2022-09-12T18:41:01.886Z"}, {"entity": "publication", "iuid": "cc3a334d201a409581528d405736ac48", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc3a334d201a409581528d405736ac48.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc3a334d201a409581528d405736ac48"}}, "title": "Efficacy of Kan Jang\u00ae in Patients with Mild COVID-19: Interim Analysis of a Randomized, Quadruple-Blind, Placebo-Controlled Trial.", "authors": [{"family": "Ratiani", "given": "Levan", "initials": "L"}, {"family": "Pachkoria", "given": "Elene", "initials": "E"}, {"family": "Mamageishvili", "given": "Nato", "initials": "N"}, {"family": "Shengelia", "given": "Ramaz", "initials": "R"}, {"family": "Hovhannisyan", "given": "Areg", "initials": "A"}, {"family": "Panossian", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8467-4525", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86a40ce1842b4c289c7f09c955ad4325.json"}}], "type": "journal article", "published": "2022-08-17", "journal": {"title": "Pharmaceuticals (Basel)", "issn": "1424-8247", "volume": "15", "issue": "8", "issn-l": null}, "abstract": "Kan Jang\u00ae, the fixed combination of Andrographis paniculata (Burm. F.) Wall. ex. Nees and Eleutherococcus senticosus (Rupr. & Maxim.) Maxim extracts, is a herbal medicinal product for relieving symptoms of upper respiratory tract infections. This study aimed to assess the efficacy of Kan Jang\u00ae/Nergecov\u00ae on duration and the relief of inflammatory symptoms in adults with mild COVID-19. 86 patients with laboratory-confirmed COVID-19 and mild symptoms for one to three days received supportive treatment (paracetamol) and six Kan Jang\u00ae (daily dose of andrographolides-90 mg) or placebo capsules a day for 14 consecutive days in this randomized, quadruple-blinded, placebo-controlled, two-parallel-group study. The primary efficacy outcomes were the decrease in the acute-phase duration and the severity of symptoms score (sore throat, runny nose, cough, headache, fatigue, loss of smell, taste, pain in muscles), an increase in cognitive functions, physical performance, quality of life, and decrease in IL-6, c-reactive protein, and D-dimer in blood. Kan Jang\u00ae/Nergecov\u00ae was effective in reducing the risk of progression to severe COVID-19, decreasing the disease progression rate by almost 2.5-fold compared to placebo. Absolute risk reduction by Kan Jang treatment is 14%, the relative risk reduction is 243.9%, and the number Needed to Treat is 7.14. Kan Jang\u00ae/Nergecov\u00ae reduces the duration of disease, virus clearance, and days of hospitalization and accelerates recovery of patients, relief of sore throat, muscle pain, runny nose, and normalization of body temperature. Kan Jang\u00ae/Nergecov\u00ae significantly relieves the severity of inflammatory symptoms such as sore throat, runny nose, and muscle pain, decreases pro-inflammatory cytokine IL-6 level in the blood, and increases patients' physical performance (workout) compared to placebo. In this study, for the first time we demonstrate that Kan Jang\u00ae/Nergecov\u00ae is effective in treating mild COVID-19.", "doi": "10.3390/ph15081013", "pmid": "36015163", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ph15081013"}, {"db": "pmc", "key": "PMC9415141"}], "notes": [], "created": "2022-09-12T19:09:35.337Z", "modified": "2022-09-12T19:10:23.139Z"}, {"entity": "publication", "iuid": "f2efe20b1f2d4472831be246d161f6c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f2efe20b1f2d4472831be246d161f6c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f2efe20b1f2d4472831be246d161f6c9"}}, "title": "Impact of ultra-processed food intake on the risk of COVID-19: a prospective cohort study.", "authors": [{"family": "Zhou", "given": "Lihui", "initials": "L"}, {"family": "Li", "given": "Huiping", "initials": "H"}, {"family": "Zhang", "given": "Shunming", "initials": "S"}, {"family": "Yang", "given": "Hongxi", "initials": "H"}, {"family": "Ma", "given": "Yue", "initials": "Y"}, {"family": "Wang", "given": "Yaogang", "initials": "Y"}], "type": "journal article", "published": "2022-08-16", "journal": {"title": "Eur J Nutr", "issn": "1436-6215", "issn-l": null}, "abstract": "Nutrition plays a key role in supporting the human immune system and reducing the risk of infections. However, there is limited evidence exploring the relationship between diet and the risk of COVID-19. This study aimed to assess the associations between consumption of ultra-processed foods (UPF) and COVID-19 risk.\n\nIn total, 41,012 participants from the UK Biobank study with at least 2 of up to 5 times 24-h dietary assessments were included in this study. Dietary intakes were collected using an online 24-h dietary recall questionnaire and food items were categorized according to their degree of processing by the NOVA classification. COVID-19 infection was defined as individuals tested COVID-19 positive or dead of COVID-19. Association between average UPF consumption (% daily gram intake) and COVID-19 infection was assessed by multivariable logistic regression adjusted for potential confounders.\n\nCompared to participants in the lowest quartile of UPF proportion (% daily gram intake) in the diet, participants in the 2nd, 3rd, and highest quartiles were associated with a higher risk of COVID-19 with the odds ratio (OR) value of 1.03 (95% CI: 0.94-1.13), 1.24 (95% CI: 1.13-1.36), and 1.22 (95% CI: 1.12-1.34), respectively (P for trend < 0.001), after adjusting for potential confounders. The results were robust in a series of sensitivity analyses. No interaction effect was identified between the UPF proportions and age groups, education level, body mass index, and comorbidity status. BMI mediated 13.2% of this association.\n\nHigher consumption of UPF was associated with an increased risk of COVID-19 infection. Further studies are needed to better understand the underlying mechanisms in such association.", "doi": "10.1007/s00394-022-02982-0", "pmid": "35972529", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00394-022-02982-0"}], "notes": [], "created": "2022-08-19T05:25:41.640Z", "modified": "2022-08-19T05:25:41.676Z"}, {"entity": "publication", "iuid": "9564edc63b0b4c53aca2c2efaa8d8244", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9564edc63b0b4c53aca2c2efaa8d8244.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9564edc63b0b4c53aca2c2efaa8d8244"}}, "title": "Fundamental social motives measured across forty-two cultures in two waves.", "authors": [{"family": "Pick", "given": "Cari M", "initials": "CM", "orcid": "0000-0002-3703-156X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78a16cde2616434d8b45e193bb7a4d2b.json"}}, {"family": "Ko", "given": "Ahra", "initials": "A"}, {"family": "Kenrick", "given": "Douglas T", "initials": "DT"}, {"family": "Wiezel", "given": "Adi", "initials": "A"}, {"family": "Wormley", "given": "Alexandra S", "initials": "AS", "orcid": "0000-0001-9892-6087", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd7c1f83116043b9b0aafb8eba3ce0f2.json"}}, {"family": "Awad", "given": "Edmond", "initials": "E", "orcid": "0000-0001-7272-7186", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3399850d2c804849830ada06b5a2c264.json"}}, {"family": "Al-Shawaf", "given": "Laith", "initials": "L", "orcid": "0000-0002-8600-0591", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5da08e43eb45476cb8f58e402a30a220.json"}}, {"family": "Barry", "given": "Oumar", "initials": "O"}, {"family": "Bereby-Meyer", "given": "Yoella", "initials": "Y"}, {"family": "Boonyasiriwat", "given": "Watcharaporn", "initials": "W"}, {"family": "Brandst\u00e4tter", "given": "Eduard", "initials": "E"}, {"family": "Ceylan-Batur", "given": "Suzan", "initials": "S"}, {"family": "Choy", "given": "Bryan K C", "initials": "BKC"}, {"family": "Crispim", "given": "Ana Carla", "initials": "AC", "orcid": "0000-0003-3434-5667", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92a6c50510514095856558adcbcea5f0.json"}}, {"family": "Cruz", "given": "Julio Eduardo", "initials": "JE"}, {"family": "David", "given": "Daniel", "initials": "D"}, {"family": "David", "given": "Oana A", "initials": "OA"}, {"family": "Defelipe", "given": "Renata Pereira", "initials": "RP"}, {"family": "Elmas", "given": "Pinar", "initials": "P"}, {"family": "Espinosa", "given": "Agust\u00edn", "initials": "A"}, {"family": "Fernandez", "given": "Ana Maria", "initials": "AM", "orcid": "0000-0003-4132-5891", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62a5afa4f51d4eedb88d47f14e79369a.json"}}, {"family": "Fetvadjiev", "given": "Velichko H", "initials": "VH", "orcid": "0000-0002-5475-5121", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d19fbc56230947648979491718129881.json"}}, {"family": "Fetvadjieva", "given": "Stefka", "initials": "S"}, {"family": "Fischer", "given": "Ronald", "initials": "R"}, {"family": "Galdi", "given": "Silvia", "initials": "S", "orcid": "0000-0002-1343-9245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1f426be397e4444ab9e2a9985db301b.json"}}, {"family": "Galindo-Caballero", "given": "Oscar Javier", "initials": "OJ", "orcid": "0000-0003-4603-6415", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a790435cd0b146b19f284104cd63b6fc.json"}}, {"family": "Golovina", "given": "Elena V", "initials": "EV", "orcid": "0000-0003-3053-6706", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5659b410753b4f908cb6b537adbb7678.json"}}, {"family": "Golovina", "given": "Galina M", "initials": "GM", "orcid": "0000-0002-2747-1422", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3331b31e6ff4acdbfc22b032356ba9f.json"}}, {"family": "Gomez-Jacinto", "given": "Luis", "initials": "L"}, {"family": "Graf", "given": "Sylvie", "initials": "S"}, {"family": "Grossmann", "given": "Igor", "initials": "I", "orcid": "0000-0003-2681-3600", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88e68a874f26479e84ddeca2112a1915.json"}}, {"family": "Gul", "given": "Pelin", "initials": "P"}, {"family": "Halama", "given": "Peter", "initials": "P"}, {"family": "Hamamura", "given": "Takeshi", "initials": "T"}, {"family": "Han", "given": "Shihui", "initials": "S"}, {"family": "Hansson", "given": "Lina S", "initials": "LS"}, {"family": "Hitokoto", "given": "Hidefumi", "initials": "H"}, {"family": "H\u0159eb\u00ed\u010dkov\u00e1", "given": "Martina", "initials": "M", "orcid": "0000-0002-8700-1326", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/224b1347d51b471f85e0f77e98166139.json"}}, {"family": "Ilic", "given": "Darinka", "initials": "D"}, {"family": "Johnson", "given": "Jennifer Lee", "initials": "JL"}, {"family": "Kara-Yakoubian", "given": "Mane", "initials": "M"}, {"family": "Karl", "given": "Johannes A", "initials": "JA"}, {"family": "Kim", "given": "Jinseok P", "initials": "JP"}, {"family": "Koh\u00fat", "given": "Michal", "initials": "M"}, {"family": "Lasselin", "given": "Julie", "initials": "J"}, {"family": "Lee", "given": "Hwaryung", "initials": "H"}, {"family": "Li", "given": "Norman P", "initials": "NP"}, {"family": "Mafra", "given": "Anthonieta Looman", "initials": "AL"}, {"family": "Malanchuk", "given": "Oksana", "initials": "O"}, {"family": "Moran", "given": "Simone", "initials": "S", "orcid": "0000-0002-2261-050X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba0b4c98e1bf4aedb45d4cb5e5c93a5c.json"}}, {"family": "Murata", "given": "Asuka", "initials": "A"}, {"family": "Na", "given": "Jinkyung", "initials": "J"}, {"family": "Ndiaye", "given": "Serigne Abdou Lahat", "initials": "SAL"}, {"family": "O", "given": "Jiaqing", "initials": "J"}, {"family": "Onyishi", "given": "Ike E", "initials": "IE"}, {"family": "Pasay-An", "given": "Eddieson", "initials": "E"}, {"family": "Rizwan", "given": "Muhammed", "initials": "M"}, {"family": "Roth", "given": "Eric", "initials": "E"}, {"family": "Salgado", "given": "Sergio", "initials": "S", "orcid": "0000-0003-1398-3416", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b6bf70dfbf74c1a8c23cdfdc6258bd1.json"}}, {"family": "Samoylenko", "given": "Elena S", "initials": "ES", "orcid": "0000-0001-7980-3903", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b10af86df3744498bfe140dcfb5a91c.json"}}, {"family": "Savchenko", "given": "Tatyana N", "initials": "TN"}, {"family": "Sette", "given": "Catarina", "initials": "C"}, {"family": "Sevincer", "given": "A Timur", "initials": "AT"}, {"family": "Skoog", "given": "Eric", "initials": "E"}, {"family": "Stanciu", "given": "Adrian", "initials": "A"}, {"family": "Suh", "given": "Eunkook M", "initials": "EM"}, {"family": "Sznycer", "given": "Daniel", "initials": "D"}, {"family": "Talhelm", "given": "Thomas", "initials": "T", "orcid": "0000-0002-0954-5758", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65d0fc062c0042479749c70085549e24.json"}}, {"family": "Ugwu", "given": "Fabian O", "initials": "FO"}, {"family": "Uskul", "given": "Ayse K", "initials": "AK"}, {"family": "Uz", "given": "Irem", "initials": "I"}, {"family": "Valentova", "given": "Jaroslava Varella", "initials": "JV"}, {"family": "Varella", "given": "Marco Antonio Correa", "initials": "MAC"}, {"family": "Wei", "given": "Liuqing", "initials": "L"}, {"family": "Zambrano", "given": "Danilo", "initials": "D"}, {"family": "Varnum", "given": "Michael E W", "initials": "MEW", "orcid": "0000-0002-2088-6086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05c99a538ea14289988c9a52f9673a37.json"}}], "type": "journal article", "published": "2022-08-16", "journal": {"title": "Sci Data", "issn": "2052-4463", "volume": "9", "issue": "1", "pages": "499", "issn-l": null}, "abstract": "H\ufeffow does psychology vary across human societies? The fundamental social motives framework adopts an evolutionary approach to capture the broad range of human social goals within a taxonomy of ancestrally recurring threats and opportunities. These motives-self-protection, disease avoidance, affiliation, status, mate acquisition, mate retention, and kin care-are high in fitness relevance and everyday salience, yet understudied cross-culturally. Here, we gathered data on these motives in 42 countries (N = 15,915) in two cross-sectional waves, including 19 countries (N = 10,907) for which data were gathered in both waves. Wave 1 was collected from mid-2016 through late 2019 (32 countries, N = 8,998; 3,302 male, 5,585 female; Mage = 24.43, SD = 7.91). Wave 2 was collected from April through November 2020, during the COVID-19 pandemic (29 countries, N = 6,917; 2,249 male, 4,218 female; Mage = 28.59, SD = 11.31). These data can be used to assess differences and similarities in people's fundamental social motives both across and within cultures, at different time points, and in relation to other commonly studied cultural indicators and outcomes.", "doi": "10.1038/s41597-022-01579-w", "pmid": "35974021", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41597-022-01579-w"}], "notes": [], "created": "2022-08-17T10:31:13.999Z", "modified": "2022-08-19T05:24:57.474Z"}, {"entity": "publication", "iuid": "b2c703b7a7ea4ae5a081a00bc6cd263e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b2c703b7a7ea4ae5a081a00bc6cd263e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b2c703b7a7ea4ae5a081a00bc6cd263e"}}, "title": "Symptoms of anxiety and depression during the COVID-19 pandemic in six European countries and Australia - Differences by prior mental disorders and migration status.", "authors": [{"family": "G\u00e9mes", "given": "Katalin", "initials": "K", "orcid": "0000-0003-3335-7850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe866acb6ee744e7a413be9348fd3463.json"}}, {"family": "Bergstr\u00f6m", "given": "Jakob", "initials": "J"}, {"family": "Papola", "given": "Davide", "initials": "D"}, {"family": "Barbui", "given": "Corrado", "initials": "C"}, {"family": "Lam", "given": "Agnes Iok Fong", "initials": "AIF"}, {"family": "Hall", "given": "Brian J", "initials": "BJ"}, {"family": "Seedat", "given": "Soraya", "initials": "S"}, {"family": "Morina", "given": "Naser", "initials": "N"}, {"family": "Quero", "given": "Soledad", "initials": "S"}, {"family": "Campos", "given": "Daniel", "initials": "D"}, {"family": "Pinucci", "given": "Irene", "initials": "I"}, {"family": "Tarsitani", "given": "Lorenzo", "initials": "L"}, {"family": "Deguen", "given": "S\u00e9verine", "initials": "S"}, {"family": "van der Waerden", "given": "Judith", "initials": "J"}, {"family": "Patan\u00e8", "given": "Martina", "initials": "M"}, {"family": "Sijbrandij", "given": "Marit", "initials": "M"}, {"family": "Acart\u00fcrk", "given": "Ceren", "initials": "C"}, {"family": "Burchert", "given": "Sebastian", "initials": "S"}, {"family": "Bryant", "given": "Richard A", "initials": "RA"}, {"family": "Mittendorfer-Rutz", "given": "Ellenor", "initials": "E"}], "type": "journal article", "published": "2022-08-15", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "volume": "311", "pages": "214-223", "issn-l": null}, "abstract": "Little is known about changes of mental health during the COVID-19 pandemic in potentially disadvantaged groups. We investigated changes in anxiety and depression symptoms during the first year of the pandemic in six European countries and Australia by prior mental disorders and migration status.\n\nOverall, 4674 adults answered a web-based survey in May-June 2020 and were followed by three repeated surveys up to February 2021. Information on psychosocial, financial and demographic, living conditions, prior mental disorders, depression and anxiety symptoms during the pandemic and migration status was collected. Weighted general estimation equations modelling was used to investigate the association between prior mental disorders, migration status, and symptoms over time.\n\nMost participants were <40 years old (48%), women (78%) and highly educated (62%). The baseline prevalence of depressive and anxiety symptoms ranged between 19%-45% and 13%-35%, respectively. In most countries, prevalence rates remained unchanged throughout the pandemic and were higher among people with prior mental disorders than without even after adjustment for several factors. We observed interactions between previous mental disorders and symptoms of anxiety or depression over time in two countries. No difference by migration status was noted.\n\nConvenience sampling limits generalizability. Self-assessed symptoms of depression and anxiety might involve some misclassification.\n\nDepression and anxiety symptoms were worse among individuals with prior mental disorders than without, but there was no clear trend of worsening mental health in the observed groups during the observed period.", "doi": "10.1016/j.jad.2022.05.082", "pmid": "35598751", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9119165"}, {"db": "pii", "key": "S0165-0327(22)00596-1"}], "notes": [], "created": "2022-06-21T17:58:19.742Z", "modified": "2023-06-19T14:52:50.464Z"}, {"entity": "publication", "iuid": "62280c2192c346a1ab87f0b00ac6c948", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/62280c2192c346a1ab87f0b00ac6c948.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/62280c2192c346a1ab87f0b00ac6c948"}}, "title": "Poor long-term recovery after critical COVID-19 during 12 months longitudinal follow-up.", "authors": [{"family": "Larsson", "given": "Ing-Marie", "initials": "IM"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Rubertsson", "given": "Sten", "initials": "S"}, {"family": "Wallin", "given": "Ewa", "initials": "E"}], "type": "journal article", "published": "2022-08-15", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "pages": "103311", "issn-l": null}, "abstract": "This study aimed to describe the burden of illness and impact on health and working situation among former intensive care patients treated for COVID-19.\n\nA prospective cohort study was performed at one intensive care unit of a university hospital in Sweden during the first wave of COVID-19 in spring 2020. The burden of illness in health status, cognitive, physical, and psychological outcomes, and working situation were assessed at four and 12 months after discharge from intensive care, using nine validated instruments.\n\nForty-six participants treated for COVID-19 participated in both follow-ups and were included in this study. General fatigue was reported by 37 of 46 participants (82%) at both follow-ups (p = 1.000). For overall health status 28 (61%) participants at the first follow-up and 26 (57%) (p = 0.414) at the second reported lower values than the general population. Cognitive impairment was seen in 22 (52%) participants at four months and in 13 (31%) at 12 months (p = 0.029). The proportion of participants on sick-leave decreased between the first and second follow-up (24% vs 13%, p = 0.025), but the proportion of participants working full-time was almost the same at both follow-ups (35% vs 37%, p = 0.317).\n\nThe burden of illness of patients treated in intensive care due to COVID-19 included cognitive, physical, and psychological impacts. Cognitive functions were improved after 12 months, but no clear improvements could be distinguished in the physical or psychological outcome. Higher burden of illness was associated with inability to return to work.", "doi": "10.1016/j.iccn.2022.103311", "pmid": "36028412", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(22)00114-8"}, {"db": "pmc", "key": "PMC9376301"}], "notes": [], "created": "2022-09-12T19:16:13.070Z", "modified": "2022-09-12T19:16:13.086Z"}, {"entity": "publication", "iuid": "11fd59eaf9764e9a8e6755f71a276a98", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/11fd59eaf9764e9a8e6755f71a276a98.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/11fd59eaf9764e9a8e6755f71a276a98"}}, "title": "Estimates of the Global Burden of COVID-19 and the Value of Broad and Equitable Access to COVID-19 Vaccines.", "authors": [{"family": "Bell", "given": "Eleanor", "initials": "E"}, {"family": "Brassel", "given": "Simon", "initials": "S"}, {"family": "Oliver", "given": "Edward", "initials": "E"}, {"family": "Schirrmacher", "given": "Hannah", "initials": "H"}, {"family": "Arnetorp", "given": "Sofie", "initials": "S"}, {"family": "Berg", "given": "Katja", "initials": "K"}, {"family": "Darroch-Thompson", "given": "Duncan", "initials": "D"}, {"family": "Pohja-Hutchison", "given": "Paula", "initials": "P"}, {"family": "Mungall", "given": "Bruce", "initials": "B", "orcid": "0000-0002-6772-1633", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/000d4730d4874855be8d266b84e473d5.json"}}, {"family": "Carroll", "given": "Stuart", "initials": "S"}, {"family": "Postma", "given": "Maarten", "initials": "M"}, {"family": "Steuten", "given": "Lotte", "initials": "L"}], "type": "journal article", "published": "2022-08-15", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "The objectives of this research were to produce a macro-level overview of the global COVID-19 burden and estimate the value of access to COVID-19 vaccines. A targeted literature review collated evidence of the burden. Linear modelling and data analysis estimated the health and economic effects of COVID-19 vaccines delivered in 2021, and whether additional value could have been achieved with broader and more equitable access. By 1 December 2020, there had been an estimated 17 million excess deaths due to COVID-19. Low-income countries allocated more than 30% of their healthcare budgets to COVID-19, compared to 8% in high-income countries. All country income groups experienced gross domestic product (GDP) growth lower than predicted in 2020. If all 92 countries eligible for COVAX Advance Market Committee (AMC), access had reached 40% vaccination coverage in 2021, 120% more excess deaths would have been averted, equivalent to USD 5 billion (109) in savings to healthcare systems. Every USD spent by advanced economies on vaccinations for less advanced economies averted USD 28 of economic losses in advanced economies and USD 29 in less advanced economies. The cost to high-income countries when not all countries are vaccinated far outweighs the cost of manufacturing and distributing vaccines globally.", "doi": "10.3390/vaccines10081320", "pmid": "36016208", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "vaccines10081320"}, {"db": "pmc", "key": "PMC9414589"}], "notes": [], "created": "2022-09-12T19:12:59.235Z", "modified": "2022-09-12T19:12:59.286Z"}, {"entity": "publication", "iuid": "6ec8cb2dc00147058afc7de3e5220305", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ec8cb2dc00147058afc7de3e5220305.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ec8cb2dc00147058afc7de3e5220305"}}, "title": "ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19.", "authors": [{"family": "Pietzner", "given": "Maik", "initials": "M", "orcid": "0000-0003-3437-9963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae2392fc827747cea946168e9ab60117.json"}}, {"family": "Chua", "given": "Robert Lorenz", "initials": "RL"}, {"family": "Wheeler", "given": "Eleanor", "initials": "E", "orcid": "0000-0002-8616-6444", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd3b1a02da1d4d2eb7ac766ba6f8bc3a.json"}}, {"family": "Jechow", "given": "Katharina", "initials": "K"}, {"family": "Willett", "given": "Julian D S", "initials": "JDS"}, {"family": "Radbruch", "given": "Helena", "initials": "H", "orcid": "0000-0001-6941-3397", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2079cbe1c9644d808083075882dfaadf.json"}}, {"family": "Trump", "given": "Saskia", "initials": "S"}, {"family": "Heidecker", "given": "Bettina", "initials": "B"}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ee1510080704cf6a2a6972deb94123f.json"}}, {"family": "Heppner", "given": "Frank L", "initials": "FL", "orcid": "0000-0001-9816-8917", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2b4021b116b445b9a1cd7cf7d82b3ba.json"}}, {"family": "Eils", "given": "Roland", "initials": "R"}, {"family": "Mall", "given": "Marcus A", "initials": "MA", "orcid": "0000-0002-4057-2199", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02b1007277d345789ac961a0d9d0eadc.json"}}, {"family": "Richards", "given": "J Brent", "initials": "JB", "orcid": "0000-0002-3746-9086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8994152547ee4765b1653b834c52a21a.json"}}, {"family": "Sander", "given": "Leif-Erik", "initials": "LE", "orcid": "0000-0002-0476-9947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36c4c59d112a4a2dbdc313dcd69c9702.json"}}, {"family": "Lehmann", "given": "Irina", "initials": "I"}, {"family": "Lukassen", "given": "S\u00f6ren", "initials": "S", "orcid": "0000-0001-7045-6327", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f138415d18c54a29a45151d2503c7166.json"}}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0003-1422-2993", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd19f9bbc2994ab3aef6731904c05dd7.json"}}, {"family": "Conrad", "given": "Christian", "initials": "C", "orcid": "0000-0001-7036-342X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee26a84058fe4316a74e87de6021b51b.json"}}, {"family": "Langenberg", "given": "Claudia", "initials": "C", "orcid": "0000-0002-5017-7344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa75a577048f439f9804254975b25c9d.json"}}], "type": "journal article", "published": "2022-08-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "4484", "issn-l": "2041-1723"}, "abstract": "Despite two years of intense global research activity, host genetic factors that predispose to a poorer prognosis of COVID-19 infection remain poorly understood. Here, we prioritise eight robust (e.g., ELF5) or suggestive but unreported (e.g., RAB2A) candidate protein mediators of COVID-19 outcomes by integrating results from the COVID-19 Host Genetics Initiative with population-based plasma proteomics using statistical colocalisation. The transcription factor ELF5 (ELF5) shows robust and directionally consistent associations across different outcome definitions, including a >4-fold higher risk (odds ratio: 4.88; 95%-CI: 2.47-9.63; p-value < 5.0 \u00d7 10-6) for severe COVID-19 per 1 s.d. higher genetically predicted plasma ELF5. We show that ELF5 is specifically expressed in epithelial cells of the respiratory system, such as secretory and alveolar type 2 cells, using single-cell RNA sequencing and immunohistochemistry. These cells are also likely targets of SARS-CoV-2 by colocalisation with key host factors, including ACE2 and TMPRSS2. In summary, large-scale human genetic studies together with gene expression at single-cell resolution highlight ELF5 as a risk gene for severe COVID-19, supporting a role of epithelial cells of the respiratory system in the adverse host response to SARS-CoV-2.", "doi": "10.1038/s41467-022-31999-6", "pmid": "35970849", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-022-31999-6"}], "notes": [], "created": "2022-08-16T15:36:49.489Z", "modified": "2022-08-16T15:36:49.829Z"}, {"entity": "publication", "iuid": "6f8eeeda1af643599fc32e33819ababb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f8eeeda1af643599fc32e33819ababb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f8eeeda1af643599fc32e33819ababb"}}, "title": "COVID-19 and Risk of Oxygen-Dependent Chronic Respiratory Failure: A National Cohort Study.", "authors": [{"family": "Sundh", "given": "Josefin", "initials": "J", "orcid": "0000-0003-1926-8464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0994c494df3b4955bedb00606add70d6.json"}}, {"family": "Ekstr\u00f6m", "given": "Magnus", "initials": "M", "orcid": "0000-0002-7227-5113", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ba0a61aa5e54bd6be6f29d7b5b02033.json"}}, {"family": "Palm", "given": "Andreas", "initials": "A", "orcid": "0000-0002-0590-0417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7f49fdf5aee42af9988590a914afb4f.json"}}, {"family": "Ljunggren", "given": "Mirjam", "initials": "M", "orcid": "0000-0002-8486-6746", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ff050327b5f4bc6834723a8244989e9.json"}}, {"family": "Emilsson", "given": "\u00d6ssur Ingi", "initials": "\u00d6I", "orcid": "0000-0002-7199-8491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/269f70619f6a4880b4f45047f43ab7e1.json"}}, {"family": "Grote", "given": "Ludger", "initials": "L", "orcid": "0000-0002-7405-1682", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8172ded15f0b4332b7ab54d7f131b87a.json"}}, {"family": "Cajander", "given": "Sara", "initials": "S", "orcid": "0000-0003-3921-4244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51683903983f4778bfda99da291f2446.json"}}, {"family": "Li", "given": "Huiqi", "initials": "H", "orcid": "0000-0002-1127-0829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e3bd3ff6b4e4f448f9332081da1dc29.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}], "type": "letter", "published": "2022-08-15", "journal": {"title": "Am J Respir Crit Care Med", "issn": "1535-4970", "issn-l": "1073-449X", "volume": "206", "issue": "4", "pages": "506-509"}, "abstract": null, "doi": "10.1164/rccm.202202-0323LE", "pmid": "35549847", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2023-01-13T09:57:49.375Z", "modified": "2023-01-13T09:59:02.287Z"}, {"entity": "publication", "iuid": "69915d78ba4142779dd2463e72168f57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69915d78ba4142779dd2463e72168f57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69915d78ba4142779dd2463e72168f57"}}, "title": "COVAD survey 2 long-term outcomes: unmet need and protocol.", "authors": [{"family": "Fazal", "given": "Zoha Zahid", "initials": "ZZ", "orcid": "0000-0003-1576-724X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ca989a85bcfc451285f65a09cc2239a7.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Ravichandran", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-0986-8354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2e6226ae5e7427fbf52e180dd14e28f.json"}}, {"family": "Kardes", "given": "Sinan", "initials": "S", "orcid": "0000-0002-6311-8634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2900c3ca00da476a8914574384a3c9c2.json"}}, {"family": "Kim", "given": "Minchul", "initials": "M", "orcid": "0000-0001-9737-6255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd2952c6167b4733bfbce019a162b310.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Selva-O'Callaghan", "given": "Albert", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0003-2823-9761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef3e202c049b44a2a5e045bac90a393a.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Guti\u00e9rrez", "given": "Carlos-Enrique Toro", "initials": "CT"}, {"family": "Caballero-Uribe", "given": "Carlo Vinicio", "initials": "CV"}, {"family": "Dey", "given": "Dzifa", "initials": "D"}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "COVAD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-08-14", "journal": {"title": "Rheumatol Int", "issn": "1437-160X", "issn-l": null}, "abstract": "Vaccine hesitancy is considered a major barrier to achieving herd immunity against COVID-19. While multiple alternative and synergistic approaches including heterologous vaccination, booster doses, and antiviral drugs have been developed, equitable vaccine uptake remains the foremost strategy to manage pandemic. Although none of the currently approved vaccines are live-attenuated, several reports of disease flares, waning protection, and acute-onset syndromes have emerged as short-term adverse events after vaccination. Hence, scientific literature falls short when discussing potential long-term effects in vulnerable cohorts. The COVAD-2 survey follows on from the baseline COVAD-1 survey with the aim to collect patient-reported data on the long-term safety and tolerability of COVID-19 vaccines in immune modulation. The e-survey has been extensively pilot-tested and validated with translations into multiple languages. Anticipated results will help improve vaccination efforts and reduce the imminent risks of COVID-19 infection, especially in understudied vulnerable groups.", "doi": "10.1007/s00296-022-05157-6", "pmid": "35964271", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00296-022-05157-6"}], "notes": [], "created": "2022-08-16T15:38:25.072Z", "modified": "2022-08-16T15:38:25.387Z"}, {"entity": "publication", "iuid": "28fe8f3c19a34e55be3411e073c704a5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/28fe8f3c19a34e55be3411e073c704a5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/28fe8f3c19a34e55be3411e073c704a5"}}, "title": "Formation of eicosanoids and other oxylipins in human macrophages.", "authors": [{"family": "Radmark", "given": "Olof", "initials": "O"}], "type": "journal article", "published": "2022-08-13", "journal": {"title": "Biochem Pharmacol", "issn": "1873-2968", "pages": "115210", "issn-l": null}, "abstract": "In this review it is attempted to summarize current studies about formation of eicosanoids and other oxylipins in different human macrophages. There are several reports on M1 and M2 cells, also other phenotypes have been described. The eicosanoids formed in the largest amounts are the COX products TxB2 and PGE2. Thus shortlived bioactive TxA2 is a dominating product both in M1- and in M2-lineages, one exception seems to be MGM-CSF, TGF\u03b2 cells. 5-LOX products are produced in both M1 and M2 macrophages, as well as in not fully polarized cells of both lineages. MM-CSF as well as M2 macrophages produced LTC4 more readily compared to M1 lineage cells. In MGM-CSF, TGF\u03b2 cells LTB4 is a major eicosanoid, in line with high expression of LTA4 hydrolase. Recent reports described increased formation of leukotrienes in macrophages subjected to trained immunity with inflammatory transcriptional reprogramming. Also in macrophages derived from monocytes collected from post-COVID-19 patients. 15-LOX-1 is strongly upregulated in CD206+ M2 cells (M2a), differentiated in presence of IL-4. These macrophages also express 15-LOX-2. In incubations with pathogenic E. coli as well as other stimuli 15(S)-HETE and 17(S)-HDHA were major oxylipins formed. Also, the SPM precursor 5,15-diHETE and the SPM RvD5 were produced in considerable amounts, while other SPMs were less abundant. In M2 macrophages incubated with E. coli or S. aureus the cytosolic 15-LOX-1 enzyme accumulated to punctuate structures in a Ca2+ dependent manner with a relatively slow time course, leading to formation of mediators from endogenous substrate. Chalcones, flavone-like anti-inflammatory natural products, induced translocation of 15-LOX-1 in M2 cells, with high formation of 15-LOX derived oxylipins.", "doi": "10.1016/j.bcp.2022.115210", "pmid": "35973581", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0006-2952(22)00304-5"}], "notes": [], "created": "2022-08-17T10:32:10.568Z", "modified": "2022-08-19T05:25:17.438Z"}, {"entity": "publication", "iuid": "4b8dde812e5f412fa4721dd0055a0926", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b8dde812e5f412fa4721dd0055a0926.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b8dde812e5f412fa4721dd0055a0926"}}, "title": "Association between use of novel glucose-lowering drugs and COVID-19 hospitalization and death in patients with type 2 diabetes: a nationwide registry analysis.", "authors": [{"family": "Ferrannini", "given": "Giulia", "initials": "G", "orcid": "0000-0002-0318-7435", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/378055a26c2c4adaa9068e96f58657fd.json"}}, {"family": "Lund", "given": "Lars H", "initials": "LH", "orcid": "0000-0003-1411-4482", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d9e6ace88b04d23ad1778c4c9d9a425.json"}}, {"family": "Benson", "given": "Lina", "initials": "L"}, {"family": "Rizzo", "given": "Manfredi", "initials": "M", "orcid": "0000-0002-9549-8504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d888593722ae4ba2b12a04effd67eaff.json"}}, {"family": "Almahmeed", "given": "Wael", "initials": "W"}, {"family": "Rosano", "given": "Giuseppe M C", "initials": "GMC"}, {"family": "Savarese", "given": "Gianluigi", "initials": "G"}, {"family": "Cosentino", "given": "Francesco", "initials": "F", "orcid": "0000-0002-6967-5685", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/992ccaa4fa4341379b1932bc0b6d1193.json"}}], "type": "journal article", "published": "2022-08-13", "journal": {"title": "Eur Heart J Cardiovasc Pharmacother", "issn": "2055-6845", "issn-l": "2055-6837"}, "abstract": "Type 2 diabetes (T2DM) in patients with coronavirus disease-19 (COVID-19) is associated with worse prognosis. We separately investigated the associations between the use of sodium-glucose cotransporter 2 inhibitors (SGLT2i), glucagon-like peptide-1 receptor agonists (GLP-1 RA) and dipeptidyl peptidase-4 inhibitors (DPP-4i), and the risk of COVID-19 hospitalization and death.\n\nPatients with T2DM registered in the Swedish National Patient Registry and alive on 1st February 2020 were included. \"Incident severe COVID-19\" was defined as the first hospitalization and/or death from COVID-19. A modified Poisson regression approach was applied to a 1:1 propensity score-matched population receiving vs. not receiving SGLT2i, GLP-1 RA and DPP-4i to analyze the associations between their use and I) incident severe COVID-19, II) risk of 30-day mortality in patients hospitalized for COVID-19.Among 344,413 patients, 39,172 (11%) were treated with SGLT2i, 34,290 (10%) with GLP-1 RA and 53,044 (15%) with DPP-4i; 9,538 (2.8%) had incident severe COVID-19 by 15th May 2021. SGLT2i and DPP-4i were associated with a 10% and 11% higher risk of incident severe COVID-19, respectively, whereas there was no association for GLP-1 RA. DPP-4i were also associated with a 10% higher 30-day mortality in patients hospitalized for COVID-19, whereas there was no association for SGLT2i and GLP-1 RA.\n\nSGLT2i and DPP-4i use was associated with higher risk of incident severe COVID-19. DPP-4i use was associated with higher 30-day mortality in patients with COVID-19, whereas SGLT2i use was not. No increased risk for any outcome was observed with GLP-1 RA.", "doi": "10.1093/ehjcvp/pvac044", "pmid": "35963647", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6665927"}], "notes": [], "created": "2022-08-16T15:38:39.733Z", "modified": "2022-08-16T15:38:39.887Z"}, {"entity": "publication", "iuid": "8c8ce2d05d554dc48bcb8c348f5b65f3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c8ce2d05d554dc48bcb8c348f5b65f3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c8ce2d05d554dc48bcb8c348f5b65f3"}}, "title": "Dispositional optimism and all-cause mortality after esophageal cancer surgery: a nationwide population-based cohort study.", "authors": [{"family": "Liu", "given": "Yangjun", "initials": "Y"}, {"family": "Pettersson", "given": "Erik", "initials": "E"}, {"family": "Schandl", "given": "Anna", "initials": "A"}, {"family": "Markar", "given": "Sheraz", "initials": "S"}, {"family": "Johar", "given": "Asif", "initials": "A"}, {"family": "Lagergren", "given": "Pernilla", "initials": "P"}], "type": "journal article", "published": "2022-08-11", "journal": {"title": "Support Care Cancer", "issn": "1433-7339", "issn-l": null}, "abstract": "To examine the association between dispositional optimism and all-cause mortality after esophageal cancer surgery and whether pathological tumor stage and the COVID-19 pandemic modified this association.\n\nThis nationwide, population-based prospective cohort study included 335 patients undergoing esophageal cancer surgery in Sweden between January 1, 2013, and December 31, 2019. Dispositional optimism was measured 1 year post-surgery using Life Orientation Test-Revised (LOT-R). A higher LOT-R sum score represents higher dispositional optimism. Mortality information was obtained from the Swedish Register of the Total Population. All patients were followed up until death or until December 31, 2020, whichever occurred first. Cox regression with adjustments for confounders was used.\n\nThe median follow-up was 20.8 months, during which 125 (37.3%) patients died. Among the included 335 patients, 219 (65.4%) patients had tumor pathologically staged Tis-II, and 300 (89.6%) patients entered the cohort before the COVID-19 pandemic. Both tumor stage and the COVID-19 pandemic were effect modifiers. For each unit increase in LOT-R sum score, the risk of all-cause mortality decreased by 11% (HR 0.89, 95% CI 0.81 to 0.98) among patients with tumor staged Tis-II before the COVID-19 pandemic. This association was non-significant in patients with tumor staged III-IV (HR 0.99, 95% CI 0.92 to 1.07) and during the COVID-19 pandemic (HR 1.08, 95% CI 0.94 to 1.25).\n\nAssessing dispositional optimism may help predict postoperative survival, especially for patients with early and intermediate esophageal cancer. Increasing dispositional optimism might be a potential intervention target to improve survival after esophageal cancer surgery.", "doi": "10.1007/s00520-022-07311-z", "pmid": "35953730", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00520-022-07311-z"}, {"db": "pmc", "key": "PMC9371627"}], "notes": [], "created": "2022-08-16T15:43:14.451Z", "modified": "2022-08-16T15:43:28.384Z"}, {"entity": "publication", "iuid": "d429910ab03c4043b50f3a1a01eb6816", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d429910ab03c4043b50f3a1a01eb6816.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d429910ab03c4043b50f3a1a01eb6816"}}, "title": "Children in the household and risk of severe COVID-19 during the first three waves of the pandemic: a prospective registry-based cohort study of 1.5 million Swedish men.", "authors": [{"family": "Af Geijerstam", "given": "Agnes", "initials": "A", "orcid": "0000-0002-0897-6548", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ab4ce35a27d446da006cd3aece117c2.json"}}, {"family": "Mehlig", "given": "Kirsten", "initials": "K"}, {"family": "Hunsberger", "given": "Monica", "initials": "M"}, {"family": "\u00c5berg", "given": "Maria", "initials": "M"}, {"family": "Lissner", "given": "Lauren", "initials": "L"}], "type": "journal article", "published": "2022-08-11", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "8", "pages": "e063640", "issn-l": "2044-6055"}, "abstract": "To investigate whether Swedish men living with children had elevated risk for severe COVID-19 or infection with SARS-CoV-2 during the first three waves of the pandemic.\n\nProspective registry-based cohort study.\n\n1 557 061 Swedish men undergoing military conscription between 1968 and 2005 at a mean age of 18.3 (SD 0.73) years.\n\nInfection with SARS-CoV-2 and hospitalisation due to COVID-19 from March 2020 to September 2021.\n\nThere was a protective association between preschool children at home and hospitalisation due to COVID-19 during the first and third waves compared with only older or no children at all, with ORs (95% CIs) 0.63 (0.46 to 0.88) and 0.75 (0.68 to 0.94) respectively. No association was observed for living with children 6-12 years old, but for 13-17 years old, the risk increased. Age in 2020 did not explain these associations. Further adjustment for socioeconomic and health factors did not attenuate the results. Exposure to preschool children also had a protective association with testing positive with SARS-CoV-2, with or without hospitalisation, OR=0.91 (95% CI 0.89 to 0.93), while living with children of other ages was associated with increased odds of infection.\n\nCohabiting with preschool children was associated with reduced risk for severe COVID-19. Living with school-age children between 6 and 12 years had no association with severe COVID-19, but sharing the household with teenagers and young adults was associated with elevated risk. Our results are of special interest since preschools and compulsory schools (age 6-15 years) in Sweden did not close in 2020.", "doi": "10.1136/bmjopen-2022-063640", "pmid": "35953248", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2022-063640"}], "notes": [], "created": "2022-08-12T08:29:46.779Z", "modified": "2022-08-12T08:30:25.309Z"}, {"entity": "publication", "iuid": "4ffb1f30bb7b4f93a2b968c49c876566", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ffb1f30bb7b4f93a2b968c49c876566.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ffb1f30bb7b4f93a2b968c49c876566"}}, "title": "A Worldwide Survey of Activities and Practices in Clinical Islet of Langerhans Transplantation.", "authors": [{"family": "Berney", "given": "Thierry", "initials": "T"}, {"family": "Andres", "given": "Axel", "initials": "A"}, {"family": "Bellin", "given": "Melena D", "initials": "MD"}, {"family": "de Koning", "given": "Eelco J P", "initials": "EJP"}, {"family": "Johnson", "given": "Paul R V", "initials": "PRV"}, {"family": "Kay", "given": "Thomas W H", "initials": "TWH"}, {"family": "Lundgren", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Rickels", "given": "Michael R", "initials": "MR"}, {"family": "Scholz", "given": "Hanne", "initials": "H"}, {"family": "Stock", "given": "Peter G", "initials": "PG"}, {"family": "White", "given": "Steve", "initials": "S"}, {"family": "International Islet Transplant Centers", "given": "", "initials": ""}], "type": "journal article", "published": "2022-08-11", "journal": {"title": "Transpl Int", "issn": "1432-2277", "volume": "35", "pages": "10507", "issn-l": null}, "abstract": "A global online survey was administered to 69 islet transplantation programs, covering 84 centers and 5 networks. The survey addressed questions on program organization and activity in the 2000-2020 period, including impact on activity of national health care coverage policies. We obtained full data from 55 institutions or networks worldwide and basic activity data from 6 centers. Additional data were obtained from alternative sources. A total of 94 institutions and 5 networks was identified as having performed islet allotransplantation. 4,365 islet allotransplants (2,608 in Europe, 1,475 in North America, 135 in Asia, 119 in Oceania, 28 in South America) were reported in 2,170 patients in the survey period. From 15 centers active at the start of the study period, the number of simultaneously active islet centers peaked at 54, to progressively decrease to 26 having performed islet allotransplants in 2020. Notably, only 16 centers/networks have done >100 islet allotransplants in the survey period. Types of transplants performed differed notably between North America and the rest of the world, in particular with respect to the near-absence of simultaneous islet-kidney transplantation. Absence of heath care coverage has significantly hampered transplant activity in the past years and the COVID-19 pandemic in 2020.", "doi": "10.3389/ti.2022.10507", "pmid": "36033644", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10507"}, {"db": "pmc", "key": "PMC9402897"}], "notes": [], "created": "2022-10-07T12:44:10.197Z", "modified": "2022-10-07T12:44:10.210Z"}, {"entity": "publication", "iuid": "d9754f165def4dd7a095cb943ff195d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d9754f165def4dd7a095cb943ff195d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d9754f165def4dd7a095cb943ff195d5"}}, "title": "Lung perfusion disturbances in non-hospitalized post-COVID with dyspnea - An MRI feasibility study.", "authors": [{"family": "Yu", "given": "Jimmy", "initials": "J", "orcid": "0000-0002-7744-3251", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed9b255a526c48b8977e46a0c3931ce3.json"}}, {"family": "Granberg", "given": "Tobias", "initials": "T", "orcid": "0000-0001-6700-1022", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9650681881d442895c1c60fdb49677e.json"}}, {"family": "Shams", "given": "Roya", "initials": "R"}, {"family": "Petersson", "given": "Sven", "initials": "S"}, {"family": "Sk\u00f6ld", "given": "Magnus", "initials": "M"}, {"family": "Nyr\u00e9n", "given": "Sven", "initials": "S"}, {"family": "Lundberg", "given": "Johan", "initials": "J", "orcid": "0000-0003-2379-8695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/488ece97feee4422994105a3b4c05e94.json"}}], "type": "journal article", "published": "2022-08-10", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null}, "abstract": "Dyspnea is common after COVID-19. Though the underlying mechanisms are largely unknown, lung perfusion abnormalities could contribute to lingering dyspnea.\n\nTo detect pulmonary perfusion disturbances in non-hospitalized individuals with post-COVID condition and persistent dyspnea 4-13 months after the disease onset.\n\nIndividuals with dyspnea and matched healthy controls were recruited for dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), a six-minute walk test, and an assessment of dyspnea. The DCE-MRI was quantified using two parametric values: mean time-to-peak (TTP) and TTP ratio, reflecting the total lung perfusion resistance and the fraction of lung with delayed perfusion, respectively.\n\nTwenty-eight persons with persistent dyspnea (mean age 46.5\u00b18.0 years, 75% women) and 22 controls (mean age 44.1\u00b110.8 years, 73% women) were included. There was no systematic sex difference in dyspnea. The post-COVID group had no focal perfusion deficits but had higher mean pulmonary TTP (0.43\u00b10.04 vs. 0.41\u00b10.03, P = 0.011) and TTP ratio (0.096\u00b10.052 vs. 0.068\u00b10.027, P = 0.032). Post-COVID males had the highest mean TTP 0.47\u00b10.02 and TTP ratio of 0.160\u00b10.039; compared to male controls and post-COVID females (P = 0.001 and P<0.001 respectively). Correlations between dyspnea and perfusion parameters were demonstrated in males (r = 0.83, P<0.001 for mean TTP; r = 0.76, P = 0.003 for TTP ratio), but not in females.\n\nDCE-MRI demonstrated late contrast bolus arrival in males with post-COVID dyspnea, suggestive of primary vascular lesions or secondary effects of hypoxic vasoconstriction. Since this effect was not regularly observed in female patients, our findings suggest sex differences in the mechanisms underlying post-COVID dyspnea, which warrants further investigation in dedicated trials. This article is protected by copyright. All rights reserved.", "doi": "10.1111/joim.13558", "pmid": "35946904", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-11T11:48:35.115Z", "modified": "2022-08-11T11:48:49.758Z"}, {"entity": "publication", "iuid": "1b8ce8c8a35543d9aaa04b01b5220449", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b8ce8c8a35543d9aaa04b01b5220449.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b8ce8c8a35543d9aaa04b01b5220449"}}, "title": "Employees Perception of Organizational Crises and Their Reactions to Them - A Norwegian Organizational Case Study.", "authors": [{"family": "S\u00f8rensen", "given": "Jarle L\u00f8we", "initials": "JL"}, {"family": "Ranse", "given": "Jamie", "initials": "J"}, {"family": "Gray", "given": "Lesley", "initials": "L"}, {"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}, {"family": "Hertelendy", "given": "Attila J", "initials": "AJ"}], "type": "journal article", "published": "2022-08-10", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "13", "pages": "818422", "issn-l": "1664-1078"}, "abstract": "Organizational sensemaking is crucial for resource planning and crisis management since facing complex strategic problems that exceed their capacity and ability, such as crises, forces organizations to engage in inter-organizational collaboration, which leads to obtaining individual and diverse perspectives to comprehend the issues and find solutions. This online qualitative survey study examines how Norwegian Sea Rescue Society employees perceived the concept of an organizational crisis and how they sensed their co-workers react to it. The scope was the ongoing COVID-19 pandemic, a global event affecting all countries and organizations and responding similarly globally. Data were collected during the Fall of 2020. The instrument of choice was the Internal Crisis Management and Crisis Communication survey (ICMCC). The results showed that the overall sample strongly believed in their organization's overall resilience level. However, a somewhat vague understanding of roles and responsibilities in a crisis where detected, together with some signs of informal communication, rumor spreading, misunderstanding, frustration, and insecurity. This study contributes to the academic field of organizational research, hence crisis management and sensemaking, and could be valuable to managers and decision-makers across sectors. Increased knowledge about how employees react to a crisis may help optimize internal crisis management planning and utilize robust mitigation and response strategies.", "doi": "10.3389/fpsyg.2022.818422", "pmid": "36033100", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9400917"}], "notes": [], "created": "2022-10-07T12:42:32.862Z", "modified": "2022-10-07T12:42:46.047Z"}, {"entity": "publication", "iuid": "bbee8ac14a4647fa850d618ac85e8671", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bbee8ac14a4647fa850d618ac85e8671.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bbee8ac14a4647fa850d618ac85e8671"}}, "title": "Predictors of post-COVID-19 and the impact of persistent symptoms in non-hospitalized patients 12 months after COVID-19, with a focus on work ability.", "authors": [{"family": "Kisiel", "given": "Marta A", "initials": "MA"}, {"family": "Janols", "given": "Helena", "initials": "H"}, {"family": "Nordqvist", "given": "Tobias", "initials": "T"}, {"family": "Bergquist", "given": "Jonas", "initials": "J"}, {"family": "Hagfeldt", "given": "Simone", "initials": "S"}, {"family": "Malinovschi", "given": "Andrei", "initials": "A"}, {"family": "Svartengren", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2022-08-09", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "volume": "127", "issn-l": "0300-9734"}, "abstract": "Better knowledge of long-term symptoms following coronavirus disease 2019 (COVID-19), the so-called post-COVID-19, in non-hospitalized patients is needed. The aim of this study was to study persisent symptoms up to 12 months after COVID-19 in non-hospitalized patients and their impact on work ability. We also investigated predictors of persistent symptoms.\n\nThis study encompassed non-hospitalized adult subjects with a COVID-19 infection confirmed via positive nasopharyngeal swab polymerase chain reaction test during the first wave of the pandemic in Uppsala, Sweden. In total, 566 subjects were sent a survey via e-mail or post with an invitation to participate in the survey 12 months post-diagnosis. The majority of subjects were healthcare workers, as this group was prioritized for testing.\n\nA total of 366 subjects responded, with 47% reporting persistent symptoms 12 months after their COVID-19 diagnosis. The most commonly reported symptoms at this time were impaired sense of smell and/or taste and fatigue. Among the predictors of persistent symptoms were being born abroad, lower physical fitness compared with peers before COVID-19, body mass index >25 kg/m2, cooccurrence of hypertension and chronic pain, and having more than seven of the general COVID-19 symptoms at the onset. Respondents with symptoms after 12 months self-reported negatively about their general health and work ability.\n\nThis study indicated that many people who had mild COVID-19 might have a variety of long-term symptoms. It highlights the importance of considering work ability after mild COVID-19.", "doi": "10.48101/ujms.v127.8794", "pmid": "35991464", "labels": {"Category: Post-COVID": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "8794"}, {"db": "pmc", "key": "PMC9383047"}], "notes": [], "created": "2022-09-12T18:51:48.050Z", "modified": "2022-09-12T18:51:48.079Z"}, {"entity": "publication", "iuid": "5b708890ca7a417f9358dc27e7737fd6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5b708890ca7a417f9358dc27e7737fd6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5b708890ca7a417f9358dc27e7737fd6"}}, "title": "Fear of COVID-19 Among Patients with Inflammatory Bowel Disease as Compared to Patients with Other Gastrointestinal Conditions.", "authors": [{"family": "Lo", "given": "Bobby", "initials": "B"}, {"family": "Barreiro-de Acosta", "given": "Manuel", "initials": "M"}, {"family": "Bernstein", "given": "Charles N", "initials": "CN"}, {"family": "Burisch", "given": "Johan", "initials": "J"}, {"family": "Ferreira", "given": "Nuno", "initials": "N"}, {"family": "Gearry", "given": "Richard B", "initials": "RB"}, {"family": "Mikocka-Walus", "given": "Antonina", "initials": "A"}, {"family": "Mokrowiecka", "given": "Anna", "initials": "A"}, {"family": "Trindade", "given": "In\u00eas A", "initials": "IA"}, {"family": "Knowles", "given": "Simon R", "initials": "SR"}], "type": "journal article", "published": "2022-08-09", "journal": {"title": "Turk J Gastroenterol", "issn": "2148-5607", "issn-l": null}, "abstract": "Although several studies have reported the impact of fears relating to coronavirus-19 on several chronic illnesses, there are few studies focused on gastrointestinal conditions. Therefore, the aim of this study was to compare the fear of coronavirus-19 in patients with inflammatory bowel disease to other gastrointestinal conditions and how the fear of COVID-19 manifests across different demographical backgrounds among inflammatory bowel disease respondents.\n\nParticipants with gastrointestinal conditions (age \u2265 18) were recruited from 27 countries. Demographic, clinical, and psycho- social information was collected. An adapted scale for inflammatory bowel disease patients measuring the fear of coronavirus-19 and gastrointestinal-specific fear of coronavirus-19 was used.\n\nIn 831 participants (312 inflammatory bowel disease), only significant increases in gastrointestinal-fear of coronavirus-19 were found in between inflammatory bowel disease and other gastrointestinal conditions (mean [standard deviation]: 13.5 [5.5] vs 10.9 [5.0], P < .01). Among inflammatory bowel disease respondents, persons on sick leave had significantly more fear of coronavirus-19 than those employed (median [IQR], 31.0 [28.5-39.5] vs 26.0 [20.0-33.0], P = .035) and significantly more gastrointestinal-fear of coro- navirus-19 compared to the employed (18.0 [14.5-22.0] vs 13.0 [9.0-17.0], P = .033) or respondents outside of the labor market (12.0 [7.0-16.0], P = .022). Persons living in a rural setting had significantly more fear of coronavirus-19 compared to persons living in regional setting (29.5 [22.0-37.8] vs 25.0 [20.0-31.3], P = .007) and gastrointestinal-fear of coronavirus-19 (15.0 [11.0-19.8] vs 12.0 [9.0-16.0], P = .02).\n\nRespondents with inflammatory bowel disease are more afraid of coronavirus-19 regarding their disease; especially, per- sons on sick leave or persons living in a rural setting. This should be taken into consideration to personalize the support that health care providers can offer in mitigating fear related to coronavirus-19.", "doi": "10.5152/tjg.2022.21774", "pmid": "35943147", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-11T11:49:37.856Z", "modified": "2022-08-11T11:49:37.892Z"}, {"entity": "publication", "iuid": "6a5ff6060a664312acc7a73a2682bba6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a5ff6060a664312acc7a73a2682bba6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a5ff6060a664312acc7a73a2682bba6"}}, "title": "Ethnic, racial and regional inequalities in access to COVID-19 vaccine, testing and hospitalization: Implications for eradication of the pandemic.", "authors": [{"family": "Ahlberg", "given": "Beth Maina", "initials": "BM"}, {"family": "Bradby", "given": "Hannah", "initials": "H"}], "type": "journal article", "published": "2022-08-09", "journal": {"title": "Front Sociol", "issn": "2297-7775", "volume": "7", "pages": "809090", "issn-l": null}, "abstract": "The COVID-19 pandemic has made visible inequalities as exemplified by unequal access to COVID-19 vaccine across and within countries; inequalities that are also apparent in rates of testing, disease, hospitalization and death from COVID-19 along class, ethnic and racial lines. For a global pandemic such as the COVID-19 to be effectively addressed, there is a need to reflect on the entrenched and structural inequalities within and between countries. While many countries in the global north have acquired more vaccines than they may need, in the global south many have very limited access. While countries in the global north had largely vaccinated their populations by 2022, those in the global south may not even complete vaccinating 70% of their population to enable them reach the so-called herd immunity by 2024. Even in the global north where vaccines are available, ethnic, racialized and poor working classes are disproportionately affected in terms of disproportionately low rates of infection and death. This paper explores the socio-economic and political structural factors that have created and maintain these disparities. In particular we sketch the role of neoliberal developments in deregulating and financializing the system, vaccine hoarding, patent protection and how this contributes to maintaining and widening disparities in access to COVID-19 vaccine and medication.", "doi": "10.3389/fsoc.2022.809090", "pmid": "36017478", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9396233"}], "notes": [], "created": "2022-09-12T19:14:28.562Z", "modified": "2022-09-12T19:14:49.442Z"}, {"entity": "publication", "iuid": "22834b2fed9548b3bb79b639f1a3d7ab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/22834b2fed9548b3bb79b639f1a3d7ab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/22834b2fed9548b3bb79b639f1a3d7ab"}}, "title": "T cell perturbations persist for at least 6 months following hospitalization for COVID-19.", "authors": [{"family": "Govender", "given": "Melissa", "initials": "M"}, {"family": "Hopkins", "given": "Francis R", "initials": "FR"}, {"family": "G\u00f6ransson", "given": "Robin", "initials": "R"}, {"family": "Svanberg", "given": "Cecilia", "initials": "C"}, {"family": "Shankar", "given": "Esaki M", "initials": "EM"}, {"family": "Hjorth", "given": "Maria", "initials": "M"}, {"family": "Nilsdotter-Augustinsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Sj\u00f6wall", "given": "Johanna", "initials": "J"}, {"family": "Nystr\u00f6m", "given": "Sofia", "initials": "S"}, {"family": "Larsson", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2022-08-08", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "13", "pages": "931039", "issn-l": "1664-3224"}, "abstract": "COVID-19 is being extensively studied, and much remains unknown regarding the long-term consequences of the disease on immune cells. The different arms of the immune system are interlinked, with humoral responses and the production of high-affinity antibodies being largely dependent on T cell immunity. Here, we longitudinally explored the effect COVID-19 has on T cell populations and the virus-specific T cells, as well as neutralizing antibody responses, for 6-7 months following hospitalization. The CD8+ TEMRA and exhausted CD57+ CD8+ T cells were markedly affected with elevated levels that lasted long into convalescence. Further, markers associated with T cell activation were upregulated at inclusion, and in the case of CD69+ CD4+ T cells this lasted all through the study duration. The levels of T cells expressing negative immune checkpoint molecules were increased in COVID-19 patients and sustained for a prolonged duration following recovery. Within 2-3 weeks after symptom onset, all COVID-19 patients developed anti-nucleocapsid IgG and spike-neutralizing IgG as well as SARS-CoV-2-specific T cell responses. In addition, we found alterations in follicular T helper (TFH) cell populations, such as enhanced TFH-TH2 following recovery from COVID-19. Our study revealed significant and long-term alterations in T cell populations and key events associated with COVID-19 pathogenesis.", "doi": "10.3389/fimmu.2022.931039", "pmid": "36003367", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9393525"}], "notes": [], "created": "2022-08-26T04:42:30.271Z", "modified": "2022-08-26T04:42:30.286Z"}, {"entity": "publication", "iuid": "c5087e20c8ef4b42b7b9db2e05de09bc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5087e20c8ef4b42b7b9db2e05de09bc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5087e20c8ef4b42b7b9db2e05de09bc"}}, "title": "Global statements to produce and implement evidence in the post-COVID-19 era provide a path forward for rehabilitation - A joint initiative of Cochrane Rehabilitation and the leading journals in the field.", "authors": [{"family": "Negrini", "given": "Stefano", "initials": "S"}, {"family": "Borg", "given": "Kristian", "initials": "K"}, {"family": "Cusick", "given": "Anne", "initials": "A"}, {"family": "Ferriero", "given": "Giorgio", "initials": "G"}, {"family": "Frontera", "given": "Walter R", "initials": "WR"}, {"family": "Gross", "given": "Douglas P", "initials": "DP"}, {"family": "Heinemann", "given": "Allen", "initials": "A"}, {"family": "Machalicek", "given": "Wendy", "initials": "W"}, {"family": "Moore", "given": "Ann Patricia", "initials": "AP"}, {"family": "Nudo", "given": "Randolph J", "initials": "RJ"}, {"family": "P\u00e9rennou", "given": "Dominic", "initials": "D"}, {"family": "Stam", "given": "Henk", "initials": "H"}, {"family": "Kiekens", "given": "Carlotte", "initials": "C"}], "type": "editorial", "published": "2022-08-08", "journal": {"title": "Ann Phys Rehabil Med", "issn": "1877-0665", "volume": "65", "issue": "5", "pages": "101688", "issn-l": null}, "abstract": null, "doi": "10.1016/j.rehab.2022.101688", "pmid": "35811074", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1877-0657(22)00060-4"}, {"db": "pmc", "key": "PMC9359696"}], "notes": [], "created": "2022-08-17T10:39:30.587Z", "modified": "2022-08-17T10:39:30.623Z"}, {"entity": "publication", "iuid": "0b5b126f50454bbc9c63c07953df7ef6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b5b126f50454bbc9c63c07953df7ef6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b5b126f50454bbc9c63c07953df7ef6"}}, "title": "DOCK2 is involved in the host genetics and biology of severe COVID-19.", "authors": [{"family": "Namkoong", "given": "Ho", "initials": "H"}, {"family": "Edahiro", "given": "Ryuya", "initials": "R"}, {"family": "Takano", "given": "Tomomi", "initials": "T", "orcid": "0000-0002-3468-0708", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adde787b5bc444f0a112ba88082598b6.json"}}, {"family": "Nishihara", "given": "Hiroshi", "initials": "H"}, {"family": "Shirai", "given": "Yuya", "initials": "Y"}, {"family": "Sonehara", "given": "Kyuto", "initials": "K"}, {"family": "Tanaka", "given": "Hiromu", "initials": "H"}, {"family": "Azekawa", "given": "Shuhei", "initials": "S"}, {"family": "Mikami", "given": "Yohei", "initials": "Y", "orcid": "0000-0001-5104-4415", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/973a5f4549f34bd48380bb590c496dc1.json"}}, {"family": "Lee", "given": "Ho", "initials": "H"}, {"family": "Hasegawa", "given": "Takanori", "initials": "T"}, {"family": "Okudela", "given": "Koji", "initials": "K"}, {"family": "Okuzaki", "given": "Daisuke", "initials": "D", "orcid": "0000-0002-4552-783X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ccf9bee61674fe38e3acf6221678f35.json"}}, {"family": "Motooka", "given": "Daisuke", "initials": "D"}, {"family": "Kanai", "given": "Masahiro", "initials": "M", "orcid": "0000-0001-5165-4408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01d858a30cea453d91cedab1fd5c8494.json"}}, {"family": "Naito", "given": "Tatsuhiko", "initials": "T", "orcid": "0000-0002-2779-4600", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b0897a4c92b4ca781c81fc0d5520385.json"}}, {"family": "Yamamoto", "given": "Kenichi", "initials": "K", "orcid": "0000-0001-9594-7050", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d494d739ff8469c9f6def67c94cb3ef.json"}}, {"family": "Wang", "given": "Qingbo S", "initials": "QS"}, {"family": "Saiki", "given": "Ryunosuke", "initials": "R", "orcid": "0000-0001-6984-7187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd5bae576b614b1f9e27c3975f2f72a2.json"}}, {"family": "Ishihara", "given": "Rino", "initials": "R", "orcid": "0000-0002-1312-6732", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d8a7f8f668d4e7989545df4ce82f649.json"}}, {"family": "Matsubara", "given": "Yuta", "initials": "Y"}, {"family": "Hamamoto", "given": "Junko", "initials": "J"}, {"family": "Hayashi", "given": "Hiroyuki", "initials": "H"}, {"family": "Yoshimura", "given": "Yukihiro", "initials": "Y"}, {"family": "Tachikawa", "given": "Natsuo", "initials": "N"}, {"family": "Yanagita", "given": "Emmy", "initials": "E"}, {"family": "Hyugaji", "given": "Takayoshi", "initials": "T"}, {"family": "Shimizu", "given": "Eigo", "initials": "E"}, {"family": "Katayama", "given": "Kotoe", "initials": "K", "orcid": "0000-0002-3966-1231", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68f93c3d200e45cea3eaea3a1758f0af.json"}}, {"family": "Kato", "given": "Yasuhiro", "initials": "Y"}, {"family": "Morita", "given": "Takayoshi", "initials": "T"}, {"family": "Takahashi", "given": "Kazuhisa", "initials": "K"}, {"family": "Harada", "given": "Norihiro", "initials": "N"}, {"family": "Naito", "given": "Toshio", "initials": "T"}, {"family": "Hiki", "given": "Makoto", "initials": "M"}, {"family": "Matsushita", "given": "Yasushi", "initials": "Y"}, {"family": "Takagi", "given": "Haruhi", "initials": "H"}, {"family": "Aoki", "given": "Ryousuke", "initials": "R"}, {"family": "Nakamura", "given": "Ai", "initials": "A"}, {"family": "Harada", "given": "Sonoko", "initials": "S"}, {"family": "Sasano", "given": "Hitoshi", "initials": "H"}, {"family": "Kabata", "given": "Hiroki", "initials": "H"}, {"family": "Masaki", "given": "Katsunori", "initials": "K"}, {"family": "Kamata", "given": "Hirofumi", "initials": "H"}, {"family": "Ikemura", "given": "Shinnosuke", "initials": "S"}, {"family": "Chubachi", "given": "Shotaro", "initials": "S"}, {"family": "Okamori", "given": "Satoshi", "initials": "S"}, {"family": "Terai", "given": "Hideki", "initials": "H"}, {"family": "Morita", "given": "Atsuho", "initials": "A"}, {"family": "Asakura", "given": "Takanori", "initials": "T"}, {"family": "Sasaki", "given": "Junichi", "initials": "J"}, {"family": "Morisaki", "given": "Hiroshi", "initials": "H"}, {"family": "Uwamino", "given": "Yoshifumi", "initials": "Y"}, {"family": "Nanki", "given": "Kosaku", "initials": "K"}, {"family": "Uchida", "given": "Sho", "initials": "S"}, {"family": "Uno", "given": "Shunsuke", "initials": "S"}, {"family": "Nishimura", "given": "Tomoyasu", "initials": "T"}, {"family": "Ishiguro", "given": "Takashi", "initials": "T"}, {"family": "Isono", "given": "Taisuke", "initials": "T"}, {"family": "Shibata", "given": "Shun", "initials": "S"}, {"family": "Matsui", "given": "Yuma", "initials": "Y"}, {"family": "Hosoda", "given": "Chiaki", "initials": "C"}, {"family": "Takano", "given": "Kenji", "initials": "K"}, {"family": "Nishida", "given": "Takashi", "initials": "T"}, {"family": "Kobayashi", "given": "Yoichi", "initials": "Y"}, {"family": "Takaku", "given": "Yotaro", "initials": "Y"}, {"family": "Takayanagi", "given": "Noboru", "initials": "N"}, {"family": "Ueda", "given": "Soichiro", "initials": "S"}, {"family": "Tada", "given": "Ai", "initials": "A"}, {"family": "Miyawaki", "given": "Masayoshi", "initials": "M"}, {"family": "Yamamoto", "given": "Masaomi", "initials": "M"}, {"family": "Yoshida", "given": "Eriko", "initials": "E"}, {"family": "Hayashi", "given": "Reina", "initials": "R"}, {"family": "Nagasaka", "given": "Tomoki", "initials": "T"}, {"family": "Arai", "given": "Sawako", "initials": "S"}, {"family": "Kaneko", "given": "Yutaro", "initials": "Y"}, {"family": "Sasaki", "given": "Kana", "initials": "K"}, {"family": "Tagaya", "given": "Etsuko", "initials": "E"}, {"family": "Kawana", "given": "Masatoshi", "initials": "M"}, {"family": "Arimura", "given": "Ken", "initials": "K"}, {"family": "Takahashi", "given": "Kunihiko", "initials": "K"}, {"family": "Anzai", "given": "Tatsuhiko", "initials": "T"}, {"family": "Ito", "given": "Satoshi", "initials": "S"}, {"family": "Endo", "given": "Akifumi", "initials": "A"}, {"family": "Uchimura", "given": "Yuji", "initials": "Y"}, {"family": "Miyazaki", "given": "Yasunari", "initials": "Y"}, {"family": "Honda", "given": "Takayuki", "initials": "T"}, {"family": "Tateishi", "given": "Tomoya", "initials": "T"}, {"family": "Tohda", "given": "Shuji", "initials": "S"}, {"family": "Ichimura", "given": "Naoya", "initials": "N"}, {"family": "Sonobe", "given": "Kazunari", "initials": "K"}, {"family": "Sassa", "given": "Chihiro Tani", "initials": "CT"}, {"family": "Nakajima", "given": "Jun", "initials": "J"}, {"family": "Nakano", "given": "Yasushi", "initials": "Y"}, {"family": "Nakajima", "given": "Yukiko", "initials": "Y"}, {"family": "Anan", "given": "Ryusuke", "initials": "R"}, {"family": "Arai", "given": "Ryosuke", "initials": "R"}, {"family": "Kurihara", "given": "Yuko", "initials": "Y"}, {"family": "Harada", "given": "Yuko", "initials": "Y"}, {"family": "Nishio", "given": "Kazumi", "initials": "K"}, {"family": "Ueda", "given": "Tetsuya", "initials": "T"}, {"family": "Azuma", "given": "Masanori", "initials": "M"}, {"family": "Saito", "given": "Ryuichi", "initials": "R"}, {"family": "Sado", "given": "Toshikatsu", "initials": "T"}, {"family": "Miyazaki", "given": "Yoshimune", "initials": "Y"}, {"family": "Sato", "given": "Ryuichi", "initials": "R"}, {"family": "Haruta", "given": "Yuki", "initials": "Y"}, {"family": "Nagasaki", "given": "Tadao", "initials": "T"}, {"family": "Yasui", "given": "Yoshinori", "initials": "Y"}, {"family": "Hasegawa", "given": "Yoshinori", "initials": "Y"}, {"family": "Mutoh", "given": "Yoshikazu", "initials": "Y"}, {"family": "Kimura", "given": "Tomoki", "initials": "T"}, {"family": "Sato", "given": "Tomonori", "initials": "T"}, {"family": "Takei", "given": "Reoto", "initials": "R"}, {"family": "Hagimoto", "given": "Satoshi", "initials": "S"}, {"family": "Noguchi", "given": "Yoichiro", "initials": "Y"}, {"family": "Yamano", "given": "Yasuhiko", "initials": "Y"}, {"family": "Sasano", "given": "Hajime", "initials": "H"}, {"family": "Ota", "given": "Sho", "initials": "S"}, {"family": "Nakamori", "given": "Yasushi", "initials": "Y"}, {"family": "Yoshiya", "given": "Kazuhisa", "initials": "K"}, {"family": "Saito", "given": "Fukuki", "initials": "F"}, {"family": "Yoshihara", "given": "Tomoyuki", "initials": "T"}, {"family": "Wada", "given": "Daiki", "initials": "D"}, {"family": "Iwamura", "given": "Hiromu", "initials": "H"}, {"family": "Kanayama", "given": "Syuji", "initials": "S"}, {"family": "Maruyama", "given": "Shuhei", "initials": "S"}, {"family": "Yoshiyama", "given": "Takashi", "initials": "T"}, {"family": "Ohta", "given": "Ken", "initials": "K"}, {"family": "Kokuto", "given": "Hiroyuki", "initials": "H"}, {"family": "Ogata", "given": "Hideo", "initials": "H"}, {"family": "Tanaka", "given": "Yoshiaki", "initials": "Y"}, {"family": "Arakawa", "given": "Kenichi", "initials": "K"}, {"family": "Shimoda", "given": "Masafumi", "initials": "M"}, {"family": "Osawa", "given": "Takeshi", "initials": "T"}, {"family": "Tateno", "given": "Hiroki", "initials": "H"}, {"family": "Hase", "given": "Isano", "initials": "I"}, {"family": "Yoshida", "given": "Shuichi", "initials": "S"}, {"family": "Suzuki", "given": "Shoji", "initials": "S"}, {"family": "Kawada", "given": "Miki", "initials": "M"}, {"family": "Horinouchi", "given": "Hirohisa", "initials": "H"}, {"family": "Saito", "given": "Fumitake", "initials": "F"}, {"family": "Mitamura", "given": "Keiko", "initials": "K"}, {"family": "Hagihara", "given": "Masao", "initials": "M"}, {"family": "Ochi", "given": "Junichi", "initials": "J"}, {"family": "Uchida", "given": "Tomoyuki", "initials": "T"}, {"family": "Baba", "given": "Rie", "initials": "R"}, {"family": "Arai", "given": "Daisuke", "initials": "D"}, {"family": "Ogura", "given": "Takayuki", "initials": "T"}, {"family": "Takahashi", "given": "Hidenori", "initials": "H"}, {"family": "Hagiwara", "given": "Shigehiro", "initials": "S"}, {"family": "Nagao", "given": "Genta", "initials": "G"}, {"family": "Konishi", "given": "Shunichiro", "initials": "S"}, {"family": "Nakachi", "given": "Ichiro", "initials": "I"}, {"family": "Murakami", "given": "Koji", "initials": "K"}, {"family": "Yamada", "given": "Mitsuhiro", "initials": "M"}, {"family": "Sugiura", "given": "Hisatoshi", "initials": "H"}, {"family": "Sano", "given": "Hirohito", "initials": "H"}, {"family": "Matsumoto", "given": "Shuichiro", "initials": "S"}, {"family": "Kimura", "given": "Nozomu", "initials": "N"}, {"family": "Ono", "given": "Yoshinao", "initials": "Y"}, {"family": "Baba", "given": "Hiroaki", "initials": "H"}, {"family": "Suzuki", "given": "Yusuke", "initials": "Y"}, {"family": "Nakayama", "given": "Sohei", "initials": "S"}, {"family": "Masuzawa", "given": "Keita", "initials": "K"}, {"family": "Namba", "given": "Shinichi", "initials": "S"}, {"family": "Suzuki", "given": "Ken", "initials": "K"}, {"family": "Naito", "given": "Yoko", "initials": "Y"}, 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"initials": "T"}, {"family": "Amiya", "given": "Saori", "initials": "S"}, {"family": "Hara", "given": "Reina", "initials": "R"}, {"family": "Yamaguchi", "given": "Yuta", "initials": "Y"}, {"family": "Murakami", "given": "Teruaki", "initials": "T"}, {"family": "Kuge", "given": "Tomoki", "initials": "T"}, {"family": "Matsumoto", "given": "Kinnosuke", "initials": "K"}, {"family": "Yamamoto", "given": "Yuji", "initials": "Y"}, {"family": "Yamamoto", "given": "Makoto", "initials": "M"}, {"family": "Yoneda", "given": "Midori", "initials": "M"}, {"family": "Kishikawa", "given": "Toshihiro", "initials": "T"}, {"family": "Yamada", "given": "Shuhei", "initials": "S"}, {"family": "Kawabata", "given": "Shuhei", "initials": "S"}, {"family": "Kijima", "given": "Noriyuki", "initials": "N"}, {"family": "Takagaki", "given": "Masatoshi", "initials": "M"}, {"family": "Sasa", "given": "Noah", "initials": "N"}, {"family": "Ueno", "given": "Yuya", "initials": "Y"}, {"family": "Suzuki", "given": "Motoyuki", 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"Takeru", "initials": "T"}, {"family": "Fujita", "given": "Kazue", "initials": "K"}, {"family": "Saito", "given": "Yoshinobu", "initials": "Y"}, {"family": "Seike", "given": "Masahiro", "initials": "M"}, {"family": "Watanabe", "given": "Hiroko", "initials": "H"}, {"family": "Matsuse", "given": "Hiroto", "initials": "H"}, {"family": "Kodaka", "given": "Norio", "initials": "N"}, {"family": "Nakano", "given": "Chihiro", "initials": "C"}, {"family": "Oshio", "given": "Takeshi", "initials": "T"}, {"family": "Hirouchi", "given": "Takatomo", "initials": "T"}, {"family": "Makino", "given": "Shohei", "initials": "S"}, {"family": "Egi", "given": "Moritoki", "initials": "M"}, {"family": "Biobank Japan Project", "given": "", "initials": ""}, {"family": "Omae", "given": "Yosuke", "initials": "Y"}, {"family": "Nannya", "given": "Yasuhito", "initials": "Y"}, {"family": "Ueno", "given": "Takafumi", "initials": "T", "orcid": "0000-0001-9219-0726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3cc40b72010340a2bba13d406334a1b3.json"}}, {"family": "Katayama", "given": "Kazuhiko", "initials": "K", "orcid": "0000-0002-7692-1151", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2c4b23a809c41d3b080359ad4ee88cd.json"}}, {"family": "Ai", "given": "Masumi", "initials": "M"}, {"family": "Fukui", "given": "Yoshinori", "initials": "Y", "orcid": "0000-0003-2335-8745", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f25a95eb6fc49f9bf216d9c223d6a0d.json"}}, {"family": "Kumanogoh", "given": "Atsushi", "initials": "A", "orcid": "0000-0003-4749-7117", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4565dd205dee4d1fa6644195ece55c6d.json"}}, {"family": "Sato", "given": "Toshiro", "initials": "T", "orcid": "0000-0001-8353-8137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e7a398c59724357ba5a2148184e914a.json"}}, {"family": "Hasegawa", "given": "Naoki", "initials": "N", "orcid": "0000-0003-0717-7450", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8e747324a074632b13eccd27a77b1cc.json"}}, {"family": "Tokunaga", "given": "Katsushi", "initials": "K"}, {"family": "Ishii", "given": "Makoto", "initials": "M", "orcid": "0000-0003-4396-1664", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/baeffc7d32584e36a16ccd0d1d39aeaa.json"}}, {"family": "Koike", "given": "Ryuji", "initials": "R"}, {"family": "Kitagawa", "given": "Yuko", "initials": "Y"}, {"family": "Kimura", "given": "Akinori", "initials": "A"}, {"family": "Imoto", "given": "Seiya", "initials": "S"}, {"family": "Miyano", "given": "Satoru", "initials": "S"}, {"family": "Ogawa", "given": "Seishi", "initials": "S"}, {"family": "Kanai", "given": "Takanori", "initials": "T"}, {"family": "Fukunaga", "given": "Koichi", "initials": "K"}, {"family": "Okada", "given": "Yukinori", "initials": "Y", "orcid": "0000-0002-0311-8472", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/180d7682259f44da968366b41662b959.json"}}], "type": "journal article", "published": "2022-08-08", "journal": {"title": "Nature", "issn": "1476-4687", "issn-l": "0028-0836"}, "abstract": "Identifying the factors underlying severe COVID-19 in the host genetics is an emerging issue1-5. We conducted a genome-wide association study (GWAS) involving 2,393 Japanese COVID-19 cases collected in initial pandemic waves with 3,289 controls, which identified a variant on 5q35 (rs60200309-A) near DOCK2 associated with severe COVID-19 in younger (<65 ages) patients (nCase=440, odds ratio=2.01, P=1.2\u00d710-8). This risk allele was prevalent in East Asians but rare in Europeans, showing a value of non-European GWAS. RNA-seq of 473 bulk peripheral blood identified decreasing effect of the risk allele on DOCK2 expression in younger patients. DOCK2 expression was suppressed in severe forms of COVID-19. Single cell RNA-seq analysis (n=61) identified cell type-specific downregulation of DOCK2 and COVID-19-specific decreasing effects of the risk allele on DOCK2 in non-classical monocytes. Immunohistochemistry of lung specimens from severe COVID-19 pneumonia showed suppressed DOCK2. Moreover, inhibition of DOCK2 function using CPYPP induced much more severe pneumonia in a Syrian hamster model of SARS-CoV-2 infection characterized as weight loss, lung edema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 plays an important role in the host immune response to SARS-CoV-2 infection and development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target.", "doi": "10.1038/s41586-022-05163-5", "pmid": "35940203", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41586-022-05163-5"}], "notes": [], "created": "2022-08-11T11:52:59.253Z", "modified": "2022-08-11T11:52:59.772Z"}, {"entity": "publication", "iuid": "b024bbc25781496fa75cd6860d48563d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b024bbc25781496fa75cd6860d48563d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b024bbc25781496fa75cd6860d48563d"}}, "title": "Coronavirus pandemic in the Nordic countries: Health policy and economy trade-off.", "authors": [{"family": "Irfan", "given": "Furqan B", "initials": "FB"}, {"family": "Minetti", "given": "Raoul", "initials": "R"}, {"family": "Telford", "given": "Ben", "initials": "B"}, {"family": "Ahmed", "given": "Fahad S", "initials": "FS"}, {"family": "Syed", "given": "Ayesha Y", "initials": "AY"}, {"family": "Hollon", "given": "Nick", "initials": "N"}, {"family": "Brauman", "given": "Seth C", "initials": "SC"}, {"family": "Cunningham", "given": "William", "initials": "W"}, {"family": "Awad", "given": "Mohamed E", "initials": "ME"}, {"family": "Saleh", "given": "Khaled J", "initials": "KJ"}, {"family": "Waljee", "given": "Akbar K", "initials": "AK"}, {"family": "Brusselaers", "given": "Nele", "initials": "N"}], "type": "journal article", "published": "2022-08-08", "journal": {"title": "J Glob Health", "issn": "2047-2986", "volume": "12", "pages": "05017", "issn-l": "2047-2978"}, "abstract": "Countries making up the Nordic region - Denmark, Finland, Iceland, Norway, and Sweden - have minimal socioeconomic, cultural, and geographical differences between them, allowing for a fair comparative analysis of the health policy and economy trade-off in their national approaches towards mitigating the impact of the COVID-19 pandemic.\n\nThis study utilized publicly available COVID-19 data of the Nordic countries from January 2020 to January 3, 2021. COVID-19 epidemiology, public health and health policy, health system capacity, and macroeconomic data were analysed for each Nordic country. Joinpoint regression analysis was performed to identify changes in temporal trends using average monthly percent change (AMPC) and average weekly percent change (AWPC).\n\nSweden's health policy, being by far the most relaxed response to COVID-19, was found to have the largest COVID-19 incidence and mortality, and the highest AWPC increases for both indicators (13.5, 95% CI = 5.6, 22.0, P < 0.001; 6.3, 95% CI = 3.5, 9.1, P < 0.001). Denmark had the highest number of COVID-19 tests per capita, consistent with their approach of increased testing as a preventive strategy for disease transmission. Iceland had the second-highest number of tests per capita due to their mass-testing, contact tracing, quarantine and isolation response. Only Norway had a significant increase in unemployment (AMPC = 2.8%, 95% CI = 0.7-4.9, P < 0.009) while the percentage change in real Gross Domestic Product (GDP) was insignificant for all countries.\n\nThere was no trade-off between public health policy and economy during the COVID-19 pandemic in the Nordic region. Sweden's relaxed and delayed COVID-19 health policy response did not benefit the economy in the short term, while leading to disproportionate COVID-19 hospitalizations and mortality.", "doi": "10.7189/jogh.12.05017", "pmid": "35932219", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-08-11T11:56:37.963Z", "modified": "2022-08-11T11:56:37.976Z"}, {"entity": "publication", "iuid": "686e9094e2a844ee97d3d70c71eba151", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/686e9094e2a844ee97d3d70c71eba151.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/686e9094e2a844ee97d3d70c71eba151"}}, "title": "Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants.", "authors": [{"family": "Monteil", "given": "Vanessa", "initials": "V", "orcid": "0000-0002-2652-5695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8ba8a0b1af6423b9cba0fc4bb3177cd.json"}}, {"family": "Eaton", "given": "Brett", "initials": "B"}, {"family": "Postnikova", "given": "Elena", "initials": "E"}, {"family": "Murphy", "given": "Michael", "initials": "M"}, {"family": "Braunsfeld", "given": "Benedict", "initials": "B", "orcid": "0000-0002-0286-8239", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a74b9e08f1e46638f44e0756d9bc4af.json"}}, {"family": "Crozier", "given": "Ian", "initials": "I"}, {"family": "Kricek", "given": "Franz", "initials": "F"}, {"family": "Niederh\u00f6fer", "given": "Janine", "initials": "J"}, {"family": "Schwarzb\u00f6ck", "given": "Alice", "initials": "A"}, {"family": "Breid", "given": "Helene", "initials": "H"}, {"family": "Devignot", "given": "Stephanie", "initials": "S", "orcid": "0000-0002-0618-5611", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bacda93ff066472489568f9273ace099.json"}}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Kellner", "given": "Max J", "initials": "MJ"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Mereiter", "given": "Stefan", "initials": "S", "orcid": "0000-0002-4832-3090", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1974c14a7be4583a96ceecccbda4f19.json"}}, {"family": "Knapp", "given": "Sylvia", "initials": "S", "orcid": "0000-0001-9016-5244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81c1b98b50754c84b62f7867c9dc453f.json"}}, {"family": "Sanchez Jimenez", "given": "Anna", "initials": "A"}, {"family": "Bugajska-Schretter", "given": "Agnes", "initials": "A", "orcid": "0000-0002-2096-5833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6fcc0fa6cf5d4023834339edd6f743db.json"}}, {"family": "Dohnal", "given": "Alexander", "initials": "A", "orcid": "0000-0002-5844-7329", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9683bf8c8dc47c38bff0cbc9232cd4a.json"}}, {"family": "Ruf", "given": "Christine", "initials": "C"}, {"family": "Gugenberger", "given": "Romana", "initials": "R"}, {"family": "Hagelkruys", "given": "Astrid", "initials": "A", "orcid": "0000-0003-3015-4038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aab27066bf2a4cfbbe675bac0df00156.json"}}, {"family": "Montserrat", "given": "Nuria", "initials": "N", "orcid": "0000-0002-1603-1755", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d4cdae2b5b34dd798f73faa0a3aa391.json"}}, {"family": "Kozieradzki", "given": "Ivona", "initials": "I", "orcid": "0000-0001-8189-3346", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c581959ead34ffe814262e1f18b0216.json"}}, {"family": "Hasan Ali", "given": "Omar", "initials": "O", "orcid": "0000-0001-5185-7520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a12bd2b13624a19be85fd370663a239.json"}}, {"family": "Stadlmann", "given": "Johannes", "initials": "J", "orcid": "0000-0001-5693-6690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab12a13b3ddd442588c1c9bda683d9ee.json"}}, {"family": "Holbrook", "given": "Michael R", "initials": "MR", "orcid": "0000-0002-0824-2667", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fca43f2c8e934b438491b1dbf3fc0e7f.json"}}, {"family": "Schmaljohn", "given": "Connie", "initials": "C"}, {"family": "Oostenbrink", "given": "Chris", "initials": "C", "orcid": "0000-0002-4232-2556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37566a0341cf4fd38366e43218cffd23.json"}}, {"family": "Shoemaker", "given": "Robert H", "initials": "RH", "orcid": "0000-0003-3608-1714", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4892275e3a6b472f9ef6a537a55e3dd8.json"}}, {"family": "Mirazimi", "given": "Ali", "initials": "A", "orcid": "0000-0003-2371-6055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0651be47429c4e5880a13b839d04fe1d.json"}}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G", "orcid": "0000-0001-7035-7038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70afca1611904e419eca43bde2d681be.json"}}, {"family": "Penninger", "given": "Josef M", "initials": "JM", "orcid": "0000-0002-8194-3777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e56aaa008524272bf252df804e06991.json"}}], "type": "journal article", "published": "2022-08-08", "journal": {"title": "EMBO Mol Med", "issn": "1757-4684", "volume": "14", "issue": "8", "pages": "e15230", "issn-l": "1757-4676"}, "abstract": "The recent emergence of multiple SARS-CoV-2 variants has caused considerable concern due to both reduced vaccine efficacy and escape from neutralizing antibody therapeutics. It is, therefore, paramount to develop therapeutic strategies that inhibit all known and future SARS-CoV-2 variants. Here, we report that all SARS-CoV-2 variants analyzed, including variants of concern (VOC) Alpha, Beta, Gamma, Delta, and Omicron, exhibit enhanced binding affinity to clinical grade and phase 2 tested recombinant human soluble ACE2 (APN01). Importantly, soluble ACE2 neutralized infection of VeroE6 cells and human lung epithelial cells by all current VOC strains with markedly enhanced potency when compared to reference SARS-CoV-2 isolates. Effective inhibition of infections with SARS-CoV-2 variants was validated and confirmed in two independent laboratories. These data show that SARS-CoV-2 variants that have emerged around the world, including current VOC and several variants of interest, can be inhibited by soluble ACE2, providing proof of principle of a pan-SARS-CoV-2 therapeutic.", "doi": "10.15252/emmm.202115230", "pmid": "35781796", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9350269"}], "notes": [], "created": "2022-08-15T15:27:01.239Z", "modified": "2022-08-15T15:27:40.940Z"}, {"entity": "publication", "iuid": "a3f700fba1f14d279a1fdcfd5903beac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3f700fba1f14d279a1fdcfd5903beac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3f700fba1f14d279a1fdcfd5903beac"}}, "title": "\"Will it Work as Well on Zoom?\" A Natural Experiment During the Covid-19 Pandemic of Delivering Parenting Groups Via Video Conferencing or in Person.", "authors": [{"family": "van Leuven", "given": "Livia", "initials": "L", "orcid": "0000-0002-2048-8600", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c90a8aae3d841b4808ef39e4db41214.json"}}, {"family": "Lalouni", "given": "Maria", "initials": "M"}, {"family": "Forster", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2022-08-08", "journal": {"title": "J Child Fam Stud", "issn": "1062-1024", "pages": "1-14", "issn-l": null}, "abstract": "While rates of child maltreatment increased during the Covid-19-pandemic, face-to-face interventions to support families got difficult to carry out due to restrictions. Meanwhile, many services do not have access to parenting programs designed for digital or remote delivery. A solution employed by some services was to use video conferencing (VC) to deliver their regular parenting programs. This study examined the effectiveness of the universal group-based parenting program ABC offered through VC instead of on-site meetings during the pandemic. Pre and post measurements were collected from 469 parents participating in either 1) ABC with VC meetings only, 2) on-site meetings only, or 3) blended - a combination of VC and on-site sessions. In addition, 74 group leaders completed a survey about their experiences of VC groups. Analyses showed general improvements in parent practices and child conduct over time, but no differences in effectiveness depending on the format of the parent group (VC, blended, or on-site). Qualitative analyses of group leaders' experiences revealed four key-themes pertaining to both challenges (e.g., concerns about parents' ability to benefit and learn parenting skills) and benefits (e.g., reaching parents who would not have been able to attend physical meetings) of VC groups. Overall, this study showed no significant differences in outcomes between the VC, blended, or on-site format of delivery. There are however limitations of this trial, and results should be considered preliminary. Effectiveness and potential negative consequences of replacing interventions intended to be delivered on-site with VC alternatives need to be further investigated in future trials.", "doi": "10.1007/s10826-022-02398-8", "pmid": "35965634", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "2398"}, {"db": "pmc", "key": "PMC9358366"}], "notes": [], "created": "2022-08-16T15:37:45.172Z", "modified": "2022-08-16T15:37:45.248Z"}, {"entity": "publication", "iuid": "49796efbb57e4d2390a404af3b639dec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49796efbb57e4d2390a404af3b639dec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49796efbb57e4d2390a404af3b639dec"}}, "title": "Subjective well-being among psychotherapists during the coronavirus disease pandemic: A cross-cultural survey from 12 european countries.", "authors": [{"family": "Van Hoy", "given": "Angelika", "initials": "A"}, {"family": "Rzeszutek", "given": "Marcin", "initials": "M"}, {"family": "Pi\u0119ta", "given": "Ma\u0142gorzata", "initials": "M"}, {"family": "Mestre", "given": "Jose M", "initials": "JM"}, {"family": "Rodr\u00edguez-Mora", "given": "\u00c1lvaro", "initials": "\u00c1"}, {"family": "Midgley", "given": "Nick", "initials": "N"}, {"family": "Omylinska-Thurston", "given": "Joanna", "initials": "J"}, {"family": "Dopierala", "given": "Anna", "initials": "A"}, {"family": "Falkenstr\u00f6m", "given": "Fredrik", "initials": "F"}, {"family": "Ferlin", "given": "Jennie", "initials": "J"}, {"family": "Gergov", "given": "Vera", "initials": "V"}, {"family": "Lazi\u0107", "given": "Milica", "initials": "M"}, {"family": "Ulberg", "given": "Randi", "initials": "R"}, {"family": "R\u00f8ssberg", "given": "Jan Ivar", "initials": "JI"}, {"family": "Hancheva", "given": "Camellia", "initials": "C"}, {"family": "Stoyanova", "given": "Stanislava", "initials": "S"}, {"family": "Schmidt", "given": "Stefanie J", "initials": "SJ"}, {"family": "Podina", "given": "Ioana R", "initials": "IR"}, {"family": "Ferreira", "given": "Nuno", "initials": "N"}, {"family": "Kagialis", "given": "Antonios", "initials": "A"}, {"family": "L\u00f6ffler-Stastka", "given": "Henriette", "initials": "H"}, {"family": "Gruszczy\u0144ska", "given": "Ewa", "initials": "E"}], "type": "journal article", "published": "2022-08-07", "journal": {"title": "J Psychiatr Res", "issn": "1879-1379", "volume": "154", "pages": "315-323", "issn-l": null}, "abstract": "The aim of this study is to examine the amount of the total variance of the subjective well-being (SWB) of psychotherapists from 12 European countries explained by between-country vs. between-person differences regarding its cognitive (life satisfaction) and affective components (positive affect [PA] and negative affect [NA]). Second, we explored a link between the SWB and their personal (self-efficacy) and social resources (social support) after controlling for sociodemographics, work characteristics, and COVID-19-related distress.\n\nIn total, 2915 psychotherapists from 12 countries (Austria, Bulgaria, Cyprus, Finland, Great Britain, Serbia, Spain, Norway, Poland, Romania, Sweden, and Switzerland) participated in this study. The participants completed the Satisfaction with Life Scale (SWLS), the International Positive and Negative Affect Schedule Short Form (I-PANAS-SF), the General Self-Efficacy Scale, and the Multidimensional Scale of Perceived Social Support.\n\nCognitive well-being (CWB; satisfaction with life) was a more country-dependent component of SWB than affective well-being (AWB). Consequently, at the individual level, significant correlates were found only for AWB but not for CWB. Higher AWB was linked to being female, older age, higher weekly workload, and lower COVID-19-related distress. Self-efficacy and social support explained AWB only, including their main effects and the moderating effect of self-efficacy.\n\nThe results highlight more individual characteristics of AWB compared to CWB, with a more critical role of low self-efficacy for the link between social support and PA rather than NA. This finding suggests the need for greater self-care among psychotherapists regarding their AWB and the more complex conditions underlying their CWB.", "doi": "10.1016/j.jpsychires.2022.07.065", "pmid": "35994913", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0022-3956(22)00443-5"}, {"db": "pmc", "key": "PMC9357039"}], "notes": [], "created": "2022-09-12T19:01:18.681Z", "modified": "2022-09-12T19:01:29.291Z"}, {"entity": "publication", "iuid": "7b4e92ff01204931bc15070565b2691c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b4e92ff01204931bc15070565b2691c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b4e92ff01204931bc15070565b2691c"}}, "title": "Effectiveness of the BNT162b2 mRNA Vaccine Compared with Hybrid Immunity in Populations Prioritized and Non-Prioritized for COVID-19 Vaccination in 2021-2022: A Naturalistic Case-Control Study in Sweden.", "authors": [{"family": "Spreco", "given": "Armin", "initials": "A", "orcid": "0000-0003-0985-8209", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29a7cab23d784f898e1706bb138caa0f.json"}}, {"family": "Dahlstr\u00f6m", "given": "\u00d6rjan", "initials": "\u00d6", "orcid": "0000-0002-3955-0443", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21ead9243d644fe3a280e7b22d974745.json"}}, {"family": "J\u00f6ud", "given": "Anna", "initials": "A", "orcid": "0000-0001-7192-4911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e038a5ce2f5a47bd89e7c221651a3d24.json"}}, {"family": "Nordvall", "given": "Dennis", "initials": "D"}, {"family": "Fagerstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Blomqvist", "given": "Eva", "initials": "E", "orcid": "0000-0003-0036-6662", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/246bd5fbd6e7428b82a39e69e5ad7491.json"}}, {"family": "Gustafsson", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-3270-171X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a43a8fb037c340d5bd85b81fcabc69d5.json"}}, {"family": "Hinkula", "given": "Jorma", "initials": "J", "orcid": "0000-0003-1908-5609", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c5c582ce23e4e608680e31197be2fc7.json"}}, {"family": "Sch\u00f6n", "given": "Thomas", "initials": "T"}, {"family": "Timpka", "given": "Toomas", "initials": "T", "orcid": "0000-0001-6049-5402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebcb4fac20f845a4bd9eaa4bf1660ebb.json"}}], "type": "journal article", "published": "2022-08-07", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "8", "pages": "1273", "issn-l": null}, "abstract": "The term hybrid immunity is used to denote the immunological status of vaccinated individuals with a history of natural infection. Reports of new SARS-CoV-2 variants of concern motivate continuous rethought and renewal of COVID-19 vaccination programs. We used a naturalistic case-control study design to compare the effectiveness of the BNT162b2 mRNA vaccine to hybrid immunity 180 days post-vaccination in prioritized and non-prioritized populations vaccinated before 31 July 2021 in three Swedish counties (total population 1,760,000). Subjects with a positive SARS-CoV-2 test recorded within 6 months before vaccination (n = 36,247; 6%) were matched to vaccinated-only controls. In the prioritized population exposed to the SARS-CoV-2 Alpha and Delta variants post-vaccination, the odds ratio (OR) for breakthrough infection was 2.2 (95% CI, 1.6\u22122.8; p < 0.001) in the vaccinated-only group compared with the hybrid immunity group, while in the later vaccinated non-prioritized population, the OR decreased from 4.3 (95% CI, 2.2\u22128.6; p < 0.001) during circulation of the Delta variant to 1.9 (95% CI, 1.7\u22122.1; p < 0.001) with the introduction of the Omicron variant (B.1.617.2). We conclude that hybrid immunity provides gains in protection, but that the benefits are smaller for risk groups and with circulation of the Omicron variant and its sublineages.", "doi": "10.3390/vaccines10081273", "pmid": "36016162", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9414381"}, {"db": "pii", "key": "vaccines10081273"}], "notes": [], "created": "2022-09-12T19:12:01.791Z", "modified": "2023-06-19T14:58:56.409Z"}, {"entity": "publication", "iuid": "13e363574aaa4eb0944287a36d5f46e9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13e363574aaa4eb0944287a36d5f46e9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13e363574aaa4eb0944287a36d5f46e9"}}, "title": "Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection.", "authors": [{"family": "Barturen", "given": "Guillermo", "initials": "G", "orcid": "0000-0003-2103-1028", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a338918e305480497c4e51b5874dd52.json"}}, {"family": "Carnero-Montoro", "given": "Elena", "initials": "E"}, {"family": "Mart\u00ednez-Bueno", "given": "Manuel", "initials": "M"}, {"family": "Rojo-Rello", "given": "Silvia", "initials": "S"}, {"family": "Sobrino", "given": "Beatriz", "initials": "B"}, {"family": "Porras-Perales", "given": "\u00d3scar", "initials": "\u00d3", "orcid": "0000-0001-7164-6616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8668d9ae7124937bad9b03d231447f3.json"}}, {"family": "Alc\u00e1ntara-Dom\u00ednguez", "given": "Clara", "initials": "C", "orcid": "0000-0002-4925-4955", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7cbf4f6c8e3f4bfea012bc2bcaf46a54.json"}}, {"family": "Bernardo", "given": "David", "initials": "D"}, {"family": "Alarc\u00f3n-Riquelme", "given": "Marta E", "initials": "ME", "orcid": "0000-0002-7632-4154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f74dd701d8442c992fe172be2d2c5bf.json"}}], "type": "journal article", "published": "2022-08-06", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "13", "issue": "1", "pages": "4597"}, "abstract": "SARS-CoV-2 infection can cause an inflammatory syndrome (COVID-19) leading, in many cases, to bilateral pneumonia, severe dyspnea, and in ~5% of these, death. DNA methylation is known to play an important role in the regulation of the immune processes behind COVID-19 progression, however it has not been studied in depth. In this study, we aim to evaluate the implication of DNA methylation in COVID-19 progression by means of a genome-wide DNA methylation analysis combined with DNA genotyping. The results reveal the existence of epigenomic regulation of functional pathways associated with COVID-19 progression and mediated by genetic loci. We find an environmental trait-related signature that discriminates mild from severe cases and regulates, among other cytokines, IL-6 expression via the transcription factor CEBP. The analyses suggest that an interaction between environmental contribution, genetics, and epigenetics might be playing a role in triggering the cytokine storm described in the most severe cases.", "doi": "10.1038/s41467-022-32357-2", "pmid": "35933486", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-022-32357-2"}, {"db": "pmc", "key": "PMC9357033"}], "notes": [], "created": "2022-08-11T11:55:38.059Z", "modified": "2022-11-18T09:52:20.620Z"}, {"entity": "publication", "iuid": "d9711d4c6520454ca075454488bedb44", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d9711d4c6520454ca075454488bedb44.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d9711d4c6520454ca075454488bedb44"}}, "title": "The Perception of the Patient Safety Climate by Health Professionals during the COVID-19 Pandemic-International Research.", "authors": [{"family": "Kosydar-Bochenek", "given": "Justyna", "initials": "J", "orcid": "0000-0003-1028-2286", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6d99072901c46bb9eadd702b89537e7.json"}}, {"family": "Krupa", "given": "Sabina", "initials": "S", "orcid": "0000-0002-3002-3153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/479d63dc95544c2ba3439438fc553192.json"}}, {"family": "Religa", "given": "Dorota", "initials": "D"}, {"family": "Friganovi\u0107", "given": "Adriano", "initials": "A", "orcid": "0000-0002-9528-6464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f01bf1aaf114c6fa7822f3dcb1d4dac.json"}}, {"family": "Oomen", "given": "Ber", "initials": "B"}, {"family": "Brioni", "given": "Elena", "initials": "E"}, {"family": "Iordanou", "given": "Stelios", "initials": "S", "orcid": "0000-0001-7618-0915", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc269f1e185e4d69a880ec7f875ff983.json"}}, {"family": "Suchoparski", "given": "Marcin", "initials": "M"}, {"family": "Knap", "given": "Ma\u0142gorzata", "initials": "M", "orcid": "0000-0003-0425-7631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d232bb7ac80463e9b4199b6a841f05a.json"}}, {"family": "M\u0119drzycka-D\u0105browska", "given": "Wioletta", "initials": "W", "orcid": "0000-0001-8377-4893", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ff04cc1fa0b4a7ba15bcdbdb287fda2.json"}}], "type": "journal article", "published": "2022-08-06", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "15", "issn-l": null}, "abstract": "The patient safety climate is a key element of quality in healthcare. It should be a priority in the healthcare systems of all countries in the world. The goal of patient safety programs is to prevent errors and reduce the potential harm to patients when using healthcare services. A safety climate is also necessary to ensure a safe working environment for healthcare professionals. The attitudes of healthcare workers toward patient safety in various aspects of work, organization and functioning of the ward are important elements of the organization's safety culture. The aim of this study was to determine the perception of the patient safety climate by healthcare workers during the COVID-19 pandemic.\n\nThe study was conducted in five European countries. The Safety Attitude Questionnaire (SAQ) short version was used for the study. A total of 1061 healthcare workers: physicians, nurses and paramedics, participated in this study.\n\nAll groups received the highest mean results on the stress recognition subscale (SR): nurses 98.77, paramedics 96.39 and physician 98.28. Nurses and physicians evaluated work conditions (WC) to be the lowest (47.19 and 44.99), while paramedics evaluated perceptions of management (PM) as the worst (46.44). Paramedics achieved statistically significantly lower scores compared to nurses and physicians in job satisfaction (JS), stress recognition (SR) and perception of management (PM) (p &lt; 0.0001). Paramedics compared to nurses and physicians rank better in working conditions (WC) in relation to patient safety (16.21%). Most often, persons of lower seniority scored higher in all subscales (p = 0.001). In Poland, Spain, France, Turkey, and Greece, healthcare workers scored highest in stress recognition (SR). In Poland, Spain, France, and Turkey, they assessed working conditions (WC) as the worst, while in Greece, the perception of management (PM) had the lowest result.\n\nParticipant perceptions about the patient safety climate were not at a particularly satisfactory level, and there is still a need for the development of patient safety culture in healthcare in Europe. Overall, positive working conditions, good management and effective teamwork can contribute to improving employees' attitudes toward patient safety. This study was carried out during the COVID-19 pandemic and should be repeated after its completion, and comparative studies will allow for a more precise determination of the safety climate in the assessment of employees.", "doi": "10.3390/ijerph19159712", "pmid": "35955067", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19159712"}, {"db": "pmc", "key": "PMC9368342"}], "notes": [], "created": "2022-08-16T15:42:44.739Z", "modified": "2022-08-16T15:42:44.963Z"}, {"entity": "publication", "iuid": "3bd9fe0e284e490b8a2809518c07b50f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3bd9fe0e284e490b8a2809518c07b50f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3bd9fe0e284e490b8a2809518c07b50f"}}, "title": "Binge-Watching and Mental Health Problems: A Systematic Review and Meta-Analysis.", "authors": [{"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Jafari", "given": "Elahe", "initials": "E", "orcid": "0000-0003-2553-8192", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2aee5b18f3b1425c85985e630c206bea.json"}}, {"family": "Potenza", "given": "Marc N", "initials": "MN", "orcid": "0000-0002-6323-1354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b6ecc2df9444fe0bd86487afa9bb58b.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Wu", "given": "Chien-Yi", "initials": "CY", "orcid": "0000-0003-0585-0293", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d56dd8eb9a114f8eb641ae5ca4764e08.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2022-08-06", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "15", "issn-l": null}, "abstract": "Binge-watching, the viewing of online videos or streamed content, may be associated with different types of mental health problems. The present study aimed to investigate the associations between binge-watching and five mental health concerns including depression, loneliness, sleep problems, anxiety, and stress.\n\nAcademic databases of PubMed, Scopus, Web of Science, ProQuest, PsycINFO, and Psych Articles were systematically searched through February of 2022. The Newcastle-Ottawa Scale was used to assess the methodological quality. A meta-analysis was performed on Fisher's z values as effect sizes, using a random effect model. Publication bias, small study effect, and moderators in this association were assessed.\n\nBinge-watching was significantly associated with the five types of mental health concerns with the most robust correlations found with stress (0.32) and anxiety (0.25). Stronger associations between binge-watching and two types of mental health problems (depression and sleep problems) were found during the COVID-19 pandemic than before the pandemic. Moreover, stronger associations between binge-watching and two types of mental health problems (stress and sleep problems) were found in developing countries than in developed countries.\n\nThe associations between binge-watching and mental health concerns were significant and positive. Programs and interventions to reduce binge-watching should be considered and tested.", "doi": "10.3390/ijerph19159707", "pmid": "35955069", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijerph19159707"}, {"db": "pmc", "key": "PMC9368441"}], "notes": [], "created": "2022-08-16T15:42:24.334Z", "modified": "2022-08-16T15:42:24.494Z"}, {"entity": "publication", "iuid": "e899b38a906b49f8a2b14ddd344b04a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e899b38a906b49f8a2b14ddd344b04a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e899b38a906b49f8a2b14ddd344b04a0"}}, "title": "A pilot clinical and radiographic study on the association between periodontitis and serious COVID-19 infection.", "authors": [{"family": "Gardelis", "given": "Panagiotis", "initials": "P"}, {"family": "Zekeridou", "given": "Alkisti", "initials": "A", "orcid": "0000-0001-9468-8958", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe50bb3ddfba4f0a89c53f18025abce1.json"}}, {"family": "Suh", "given": "Noemie", "initials": "N"}, {"family": "Le Terrier", "given": "Christophe", "initials": "C"}, {"family": "Stavropoulos", "given": "Andreas", "initials": "A", "orcid": "0000-0001-8161-3754", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c54209640baf41f4bc60dcec6174e241.json"}}, {"family": "Giannopoulou", "given": "Catherine", "initials": "C"}], "type": "journal article", "published": "2022-08-06", "journal": {"title": "Clin Exp Dent Res", "issn": "2057-4347", "issn-l": null}, "abstract": "During the pandemic of COVID-19, the scientific community tried to identify the risk factors that aggravate the viral infection. Oral health and specifically periodontitis have been shown to have a significant impact on overall health. Current, yet limited, evidence suggests a link between periodontal status and severity of COVID-19 infection.\n\nThe present pilot study aimed to assess whether younger patients (\u226460 years) that have been hospitalized in the intensive care unit (ICU) for severe COVID-19 infection were susceptible to severe periodontitis.\n\nAll dentate patients \u226460 years of age diagnosed with COVID-19 and surviving hospitalization in the ICU were considered for inclusion. Susceptibility to periodontitis was determined by assessing radiographic bone loss (RBL) in recent dental radiographs (posterior bitewings, periapical, and panoramic X-rays). RBL in % was obtained from the most affected tooth and patients were classified into: Stage I, RBL \u2264 15%; Stage II, RBL = 15%-33% and Stage III/IV, RBL \u2265 33%. The grade was defined using the RBL to age ratio on the most severely affected tooth. Patients were attributed to: Grade A, ratio <0.25; Grade B, ratio 0.25-1 and Grade C, ratio >1. Patients classified into Stage III/IV and Grade C were considered highly susceptible to periodontitis.\n\nOf 87 eligible patients, 30 patients were finally assessed radiographically and/or clinically; from the remaining 57 patients, 16 refused participation for various reasons and 41 could not be reached. Based on the radiographic assessment, all patients were periodontally compromised. Half of them were classified with Stage III/IV and Grade B or C; 26.7% were classified with Stage III/IV and Grade C.\n\nThe present pilot study showed that about half of the patients suffering from severe forms of COVID-19 infection in need of ICU admission suffered also from severe periodontitis, and about one-fourth of them were highly susceptible to it.", "doi": "10.1002/cre2.610", "pmid": "35932180", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-11T11:56:56.240Z", "modified": "2022-08-11T11:56:56.345Z"}, {"entity": "publication", "iuid": "aee729d636e1464e89c86ae436a9c572", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aee729d636e1464e89c86ae436a9c572.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aee729d636e1464e89c86ae436a9c572"}}, "title": "Vaccination nudges: A study of pre-booked COVID-19 vaccinations in Sweden.", "authors": [{"family": "Bonander", "given": "Carl", "initials": "C"}, {"family": "Ekman", "given": "Mats", "initials": "M"}, {"family": "Jakobsson", "given": "Niklas", "initials": "N"}], "type": "journal article", "published": "2022-08-05", "journal": {"title": "Soc Sci Med", "issn": "1873-5347", "volume": "309", "pages": "115248", "issn-l": null}, "abstract": "A nudge changes people's actions without removing their options or altering their incentives. During the COVID-19 vaccine rollout, the Swedish Region of Uppsala sent letters with pre-booked appointments to inhabitants aged 16-17 instead of opening up manual appointment booking. Using regional and municipal vaccination data, we document a higher vaccine uptake among 16- to 17-year-olds in Uppsala compared to untreated control regions (constructed using the synthetic control method as well as neighboring municipalities). The results highlight pre-booked appointments as a strategy for increasing vaccination rates in populations with low perceived risk.", "doi": "10.1016/j.socscimed.2022.115248", "pmid": "35969977", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0277-9536(22)00554-8"}, {"db": "pmc", "key": "PMC9354447"}], "notes": [], "created": "2022-08-16T15:37:03.576Z", "modified": "2022-08-19T05:26:49.553Z"}, {"entity": "publication", "iuid": "9a3667b343c94f65adf60d2de6216896", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9a3667b343c94f65adf60d2de6216896.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9a3667b343c94f65adf60d2de6216896"}}, "title": "Risk factors for anxiety and depression among pregnant women during COVID-19 pandemic - results of a web-based multinational cross-sectional study.", "authors": [{"family": "Kajdy", "given": "Anna", "initials": "A"}, {"family": "Sys", "given": "Dorota", "initials": "D"}, {"family": "Pokropek", "given": "Artur", "initials": "A"}, {"family": "Shaw", "given": "Steven W", "initials": "SW"}, {"family": "Chang", "given": "Tung-Yao", "initials": "TY"}, {"family": "Calda", "given": "Pavel", "initials": "P"}, {"family": "Acharya", "given": "Ganesh", "initials": "G"}, {"family": "Ben-Zion", "given": "Maya", "initials": "M"}, {"family": "Biron-Shental", "given": "Tal", "initials": "T"}, {"family": "Borowski", "given": "Dariusz", "initials": "D"}, {"family": "Czuba", "given": "Bartosz", "initials": "B"}, {"family": "Etchegaray", "given": "Adolfo", "initials": "A"}, {"family": "Feduniw", "given": "Stepan", "initials": "S"}, {"family": "Garcia-Mandujano", "given": "Rosario", "initials": "R"}, {"family": "Garcia Santacruz", "given": "Monica", "initials": "M"}, {"family": "Gil", "given": "Maria M", "initials": "MM"}, {"family": "Hassan", "given": "Sonia", "initials": "S"}, {"family": "Kwiatkowski", "given": "Sebastian", "initials": "S"}, {"family": "Martin-Arias", "given": "Arancha", "initials": "A"}, {"family": "Martinez-Portilla", "given": "Raigam Jafet", "initials": "RJ"}, {"family": "Prefumo", "given": "Federico", "initials": "F"}, {"family": "Rabijewski", "given": "Micha\u0142", "initials": "M"}, {"family": "Salomon", "given": "Laurent J", "initials": "LJ"}, {"family": "Tiller", "given": "Heidi", "initials": "H"}, {"family": "Verlohren", "given": "Stefan", "initials": "S"}, {"family": "Voon", "given": "Hian Yan", "initials": "HY"}, {"family": "Fernando Yanque-Robles", "given": "Omar", "initials": "O"}, {"family": "Yong", "given": "Soon Leong", "initials": "SL"}, {"family": "Poon", "given": "Liona C", "initials": "LC"}, {"family": "Mind-COVID Collaborative Team", "given": "", "initials": ""}], "type": "journal article", "published": "2022-08-05", "journal": {"title": "Int J Gynaecol Obstet", "issn": "1879-3479", "issn-l": null}, "abstract": "Mind-COVID is a prospective cross-sectional study aimed to assess risk factors for anxiety and depression among pregnant women during the COVID-19 pandemic. This study compares outcomes in middle-income economies and high-income economies.\n\n7,102 pregnant women from 12 high-income economies and 9 middle-income economies were included. The web-based survey used two standardised instruments, GAD-7 and PHQ-9.\n\nPregnant women in high-income economies reported higher PHQ-9 (0.18 SD, p<<0.001) and GAD-7 (0.08 SD, p=0.005) scores than those living in middle-income economies. Multivariate regression analysis showed that increasing PHQ-9 and GAD-7 scales were associated with mental health problems during pregnancy and the need of psychiatric treatment before pregnancy. PHQ-9 was associated with feeling of burden related to restrictions in social distancing and access to leisure activities. GAD-7 scores were associated with a pregnancy-related complication, fear of adverse outcomes in children related to COVID-19 and feeling of burden related to finances.\n\nAccording to this study, the imposed public health measures and hospital restrictions have left pregnant women more vulnerable during these difficult times. Adequate partner and family support during pregnancy and childbirth can be one of the most important protective factors against anxiety and depression, regardless of national economic status.", "doi": "10.1002/ijgo.14388", "pmid": "35932096", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-11T11:57:19.817Z", "modified": "2022-08-11T11:57:19.852Z"}, {"entity": "publication", "iuid": "3a7132762a8a493a89cfdd6c056d3dce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a7132762a8a493a89cfdd6c056d3dce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a7132762a8a493a89cfdd6c056d3dce"}}, "title": "Challenges imposed by the COVID-19 pandemic on the Obstetrics and Gynecology residency program: a mixed-methods Swedish survey in the COPE Staff cohort study.", "authors": [{"family": "W\u00e5dell", "given": "Matilda", "initials": "M"}, {"family": "\u00d6rtqvist", "given": "Anne K", "initials": "AK"}, {"family": "Linden", "given": "Karolina", "initials": "K"}, {"family": "Akerstrom", "given": "Magnus", "initials": "M"}, {"family": "Andersson", "given": "Ola", "initials": "O"}, {"family": "Carlsson", "given": "Ylva", "initials": "Y"}, {"family": "Graner", "given": "Sofie", "initials": "S"}, {"family": "Jonsson", "given": "Maria", "initials": "M"}, {"family": "Naurin", "given": "Elin", "initials": "E"}, {"family": "Sengpiel", "given": "Verena", "initials": "V"}, {"family": "Veje", "given": "Malin", "initials": "M"}, {"family": "Wessberg", "given": "Anna", "initials": "A"}, {"family": "Zaigham", "given": "Mehreen", "initials": "M"}], "type": "journal article", "published": "2022-08-05", "journal": {"title": "BMC Med Educ", "issn": "1472-6920", "volume": "22", "issue": "1", "pages": "602", "issn-l": null}, "abstract": "To outline how the training program and work situation of residents in Obstetrics and Gynecology (OB-GYN) was affected by the pandemic and to illuminate how residents experienced these changes.\n\nAs part of the COVID-19 in Pregnancy and Early Childhood Staff (COPE Staff) cohort study, between January and May 2021, all participating residents were invited to answer a 28-question online Resident Survey focusing on their specialist education, work situation and experiences during the COVID-19 pandemic. Descriptive statistics were given in percentages for categorical variables and means and standard deviations (SD) for continuous variables. Univariate comparative analyses were performed with the use of the Pearson's Chi-2-test for dichotomous data. The association between residents' worry about the quality and length of their specialist training, with extra clinical hours and transfer to other healthcare institutions were assessed by multivariate logistic regression. Free text responses were analyzed by content analysis.\n\nOf the 162 participating OB-GYN residents, 69% expressed concern that the pandemic would have a negative impact on their training. Ninety-five (95%) reported cancellation/postponement of educational activities, 70% performed fewer surgeries and 27% had been transferred to other healthcare institutions where about half reported having gained more general knowledge as a physician. Working extra clinical hours was reported by 69% (7.4 \u00b1 5.3 hours per week) and 14% had considered changing their profession due to the pandemic. Senior residents, compared to junior residents, more often experienced cancelled/postponed clinical rotations (30% vs 15%, P=0.02) and reported performing fewer surgeries (P=0.02). The qualitative analysis highlighted the lack of surgical procedural training as a major concern for residents.\n\nThe COVID-19 pandemic has strongly impacted the training program and work situation of OB-GYN residents in Sweden. Residents were concerned over the negative impact of the pandemic on their training program and senior residents reported more missed educational opportunities as compared to junior residents. Program directors, head of institutions and clinical supervisors can use the problem areas pinpointed by this study to support residents and compensate for missed educational opportunities. While hands-on-training and operating time cannot be compensated for, the authors hope that the findings of the study can help develop new strategies to minimize the negative impact of the current and future pandemics on resident education and work situation.", "doi": "10.1186/s12909-022-03631-0", "pmid": "35927725", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12909-022-03631-0"}, {"db": "pmc", "key": "PMC9354310"}], "notes": [], "created": "2022-08-11T12:00:24.793Z", "modified": "2022-08-11T12:00:24.806Z"}, {"entity": "publication", "iuid": "76979789107a4e098eaecbc23e9e6f00", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76979789107a4e098eaecbc23e9e6f00.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76979789107a4e098eaecbc23e9e6f00"}}, "title": "COVID-19 vaccination in pregnant women in Sweden and Norway.", "authors": [{"family": "\u00d6rtqvist", "given": "Anne K", "initials": "AK"}, {"family": "Dahlqwist", "given": "Elisabeth", "initials": "E"}, {"family": "Magnus", "given": "Maria C", "initials": "MC"}, {"family": "Ljung", "given": "Rickard", "initials": "R"}, {"family": "Jonsson", "given": "Jerker", "initials": "J"}, {"family": "Aronsson", "given": "Bernice", "initials": "B"}, {"family": "Pasternak", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}], "type": "journal article", "published": "2022-08-05", "journal": {"title": "Vaccine", "issn": "1873-2518", "volume": "40", "issue": "33", "pages": "4686-4692", "issn-l": null}, "abstract": "Vaccines against SARS-CoV-2 are highly effective in preventing severe disease and mortality. Although pregnant women are at increased risk of severe COVID-19, vaccination uptake among pregnant women varies. We used the Swedish and Norwegian population-based health registries to identify pregnant women and to investigate background characteristics associated with not being vaccinated. In this study of 164 560 women giving birth between May 2021 and May 2022, 78% in Sweden and 87% in Norway have been vaccinated with at least one dose at delivery. Not being vaccinated while being pregnant was associated with age below 30 years, low education and income level, birth region other than Scandinavia, smoking during pregnancy, not living with a partner, and gestational diabetes. These results can assist health authorities develop targeted vaccination information to diminish vaccination inequality and prevent severe disease in vulnerable groups.", "doi": "10.1016/j.vaccine.2022.06.083", "pmid": "35842337", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Vaccines": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9273610"}, {"db": "pii", "key": "S0264-410X(22)00859-3"}], "notes": [], "created": "2022-08-12T08:54:24.048Z", "modified": "2023-07-13T11:30:28.895Z"}, {"entity": "publication", "iuid": "e0144e1b48894804a2c8a78d0f70a85b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e0144e1b48894804a2c8a78d0f70a85b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e0144e1b48894804a2c8a78d0f70a85b"}}, "title": "South African University Staff and Students' Perspectives, Preferences, and Drivers of Hesitancy Regarding COVID-19 Vaccines: A Multi-Methods Study.", "authors": [{"family": "George", "given": "Gavin", "initials": "G", "orcid": "0000-0001-7258-8470", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1047f3615ff7472ca7153120996b5a3d.json"}}, {"family": "Strauss", "given": "Michael", "initials": "M", "orcid": "0000-0001-7849-8812", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2460c075273474ca7b13a37b7c309ae.json"}}, {"family": "Lansdell", "given": "Emma", "initials": "E"}, {"family": "Nadesan-Reddy", "given": "Nisha", "initials": "N"}, {"family": "Moroe", "given": "Nomfundo", "initials": "N", "orcid": "0000-0001-7186-5632", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7fc9e62155c4629b1dfb65c3fc49876.json"}}, {"family": "Reddy", "given": "Tarylee", "initials": "T"}, {"family": "Eshun-Wilsonova", "given": "Ingrid", "initials": "I"}, {"family": "Moshabela", "given": "Mosa", "initials": "M"}], "type": "journal article", "published": "2022-08-04", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "COVID-19 vaccine hesitancy poses a threat to the success of vaccination programmes currently being implemented. Concerns regarding vaccine effectiveness and vaccine-related adverse events are potential barriers to vaccination; however, it remains unclear whether tailored messaging and vaccination programmes can influence uptake. Understanding the preferences of key groups, including students, could guide the implementation of youth-targeted COVID-19 vaccination programmes, ensuring optimal uptake. This study examined university staff and students' perspectives, preferences, and drivers of hesitancy regarding COVID-19 vaccines. A multi-methods approach was used-an online convenience sample survey and discrete choice experiment (DCE)-targeting staff and students at the University of KwaZulu-Natal, South Africa. The survey and DCE were available for staff and students, and data were collected from 18 November to 24 December 2021. The survey captured demographic characteristics as well as attitudes and perspectives of COVID-19 and available vaccines using modified Likert rating questions adapted from previously used tools. The DCE was embedded within the survey tool and varied critical COVID-19 vaccine programme characteristics to calculate relative utilities (preferences) and determine trade-offs. A total of 1836 staff and students participated in the study (541 staff, 1262 students, 33 undisclosed). A total of 1145 (62%) respondents reported that they had been vaccinated against COVID-19. Vaccination against COVID-19 was less prevalent among students compared with staff (79% of staff vs. 57% of students). The vaccine's effectiveness (22%), and its safety (21%), ranked as the two dominant reasons for not getting vaccinated. These concerns were also evident from the DCE, with staff and students being significantly influenced by vaccine effectiveness, with participants preferring highly effective vaccines (90% effective) as compared with those listed as being 70% or 50% effective (\u03b2 = -3.72, 95% CI = -4.39 to -3.04); this characteristic had the strongest effect on preferences of any attribute. The frequency of vaccination doses was also found to have a significant effect on preferences with participants deriving less utility from choice alternatives requiring two initial vaccine doses compared with one dose (\u03b2 = -1.00, 95% CI = -1.42 to -0.58) or annual boosters compared with none (\u03b2 = -2.35, 95% CI = -2.85 to -1.86). Notably, an incentive of ZAR 350 (USD 23.28) did have a positive utility (\u03b2 = 1.14, 95% CI = 0.76 to 1.53) as compared with no incentive. Given the slow take-up of vaccination among youth in South Africa, this study offers valuable insights into the factors that drive hesitancy among this population. Concerns have been raised around the safety and effectiveness of vaccines, although there remains a predilection for efficient services. Respondents were not enthusiastic about the prospect of having to take boosters, and this has played out in the roll-out data. Financial incentives may increase both the uptake of the initial dose of vaccines and see a more favourable response to subsequent boosters. Universities should consider tailored messaging regarding vaccine effectiveness and facilitate access to vaccines, to align services with the stated preferences of staff and students.", "doi": "10.3390/vaccines10081250", "pmid": "36016138", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "vaccines10081250"}, {"db": "pmc", "key": "PMC9412872"}], "notes": [], "created": "2022-09-12T19:11:37.572Z", "modified": "2022-09-12T19:11:37.697Z"}, {"entity": "publication", "iuid": "f1d0a53cf20a4652a557b646d63a1bfb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1d0a53cf20a4652a557b646d63a1bfb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1d0a53cf20a4652a557b646d63a1bfb"}}, "title": "Impaired physical function in patients with idiopathic inflammatory myopathies: results from the multicentre COVAD patient-reported e-survey.", "authors": [{"family": "Yoshida", "given": "Akira", "initials": "A", "orcid": "0000-0003-3590-1637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e26dfbeb7e8486a8492abc2700590df.json"}}, {"family": "Kim", "given": "Minchul", "initials": "M", "orcid": "0000-0001-9737-6255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd2952c6167b4733bfbce019a162b310.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Naveen", "given": "R", "initials": "R", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A", "orcid": "0000-0002-8748-898X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d98b671fd6f42abb53ef23bce42e498.json"}}, {"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-0986-8354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2e6226ae5e7427fbf52e180dd14e28f.json"}}, {"family": "Kardes", "given": "Sinan", "initials": "S", "orcid": "0000-0002-6311-8634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2900c3ca00da476a8914574384a3c9c2.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M", "orcid": "0000-0001-7312-351X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c31a936f1a409280bf9a4f7edbfd26.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Edgar Gracia-Ramos", "given": "Abraham", "initials": "A", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "O'Callaghan", "given": "Albert Selva", "initials": "AS", "orcid": "0000-0003-2823-9761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef3e202c049b44a2a5e045bac90a393a.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "COVAD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-08-03", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "issn-l": null}, "abstract": "The assessment of physical function is fundamental in the management of patients with idiopathic inflammatory myopathies (IIMs). We aimed to investigate the physical function of patients with IIMs compared with those with non-IIM autoimmune rheumatic diseases (AIRDs) utilizing Patient-Reported Outcome Measurement Information System (PROMIS) Physical Function (PF) data obtained in the COVAD study, an international self-reported e-survey assessing the safety of COVID-19 vaccines in AIRDs.\n\nDemographics, AIRD diagnosis, disease activity, and PROMIS PF short form-10a data were extracted from the COVAD database. PROMIS PF-10a scores were compared between disease categories and stratified by disease activity. Factors affecting PROMIS PF-10a scores other than disease activity were identified by multivariable regression analysis in patients with inactive disease.\n\n1057 IIM patients, 3635 non-IIM AIRD patients, and 3981 healthy controls (HCs) responded to the COVAD e-survey from April to August 2021. Using a binomial regression model, the predicted mean of PROMIS PF-10a scores was significantly lower in IIM patients compared with non-IIM AIRD patients or HCs (36.3 [95% confidence interval (CI) 35.5-37.1] vs 41.3 [95%CI 40.2-42.5] vs 46.2 [95%CI 45.8-46.6], P < 0.001), irrespective of disease activity. The independent factors for lower PROMIS PF-10a scores in patients with inactive disease were older age, female, longer disease duration, and a diagnosis of inclusion body myositis or polymyositis.\n\nPhysical function is significantly impaired in IIMs compared with non-IIM AIRDs or HCs, even in patients with inactive disease. Our study highlights a critical need for better strategies to minimize functional disability in patients with IIMs.", "doi": "10.1093/rheumatology/keac441", "pmid": "35920795", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6654606"}], "notes": [], "created": "2022-08-11T12:01:35.086Z", "modified": "2022-08-11T12:01:35.444Z"}, {"entity": "publication", "iuid": "8e6e2fe558dd4111892768da43c2a8f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e6e2fe558dd4111892768da43c2a8f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e6e2fe558dd4111892768da43c2a8f9"}}, "title": "Pre-pandemic Alzheimer Disease Biomarkers and Anxious-Depressive Symptoms During the COVID-19 Confinement in Cognitively Unimpaired Adults.", "authors": [{"family": "Akinci", "given": "Muge", "initials": "M"}, {"family": "Pe\u00f1a-G\u00f3mez", "given": "Cleof\u00e9", "initials": "C"}, {"family": "Operto", "given": "Gregory", "initials": "G"}, {"family": "Fuentes-Julian", "given": "Sherezade", "initials": "S"}, {"family": "Deulofeu", "given": "Carme", "initials": "C"}, {"family": "S\u00e1nchez-Benavides", "given": "Gonzalo", "initials": "G"}, {"family": "Mil\u00e0-Alom\u00e0", "given": "Marta", "initials": "M"}, {"family": "Grau-Rivera", "given": "Oriol", "initials": "O"}, {"family": "Gramunt", "given": "Nina", "initials": "N"}, {"family": "Navarro", "given": "Arcadi", "initials": "A"}, {"family": "Minguill\u00f3n", "given": "Carolina", "initials": "C"}, {"family": "Fauria", "given": "Karine", "initials": "K"}, {"family": "Suridjan", "given": "Ivonne", "initials": "I"}, {"family": "Kollmorgen", "given": "Gwendlyn", "initials": "G"}, {"family": "Bayfield", "given": "Anna", "initials": "A"}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/351fab09f6e24b9f9e6695da83947cb6.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0002-4671-6763", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79e95c490f72402196c43d602ce8e708.json"}}, {"family": "Molinuevo", "given": "Jos\u00e9 Luis", "initials": "JL"}, {"family": "Su\u00e1rez-Calvet", "given": "Marc", "initials": "M"}, {"family": "Gispert", "given": "Juan Domingo", "initials": "JD", "orcid": "0000-0002-6155-0642", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a88d83a5ca4c4a9ea428fcb3f339ca34.json"}}, {"family": "Arenaza-Urquijo", "given": "Eider M", "initials": "EM"}], "type": "journal article", "published": "2022-08-02", "journal": {"title": "Neurology", "issn": "1526-632X", "issn-l": "0028-3878"}, "abstract": "Increased anxious-depressive symptomatology is observed in the preclinical stage of Alzheimer's disease (AD), which may accelerate disease progression. We investigated whether amyloid-\u03b2, , neuroinflammation and sociodemographic factors were associated with cortical thickness in medial temporal lobe structures anxious-depressive symptoms during the COVID-19 confinement.greater\n\nThis retrospective observational study included cognitively unimpaired older adults from the ALFA (Alzheimer and FAmilies) cohort, the majority with a family history of sporadic AD. Participants performed the Hospital Anxiety and Depression Scale (HADS) during the COVID-19 confinement. A subset had available retrospective (on average: 2.4 years before) HADS assessment, amyloid [18F] flutemetamol PET and structural MRI scans and CSF markers of neuroinflammation (interleukin-6 [IL-6], triggering receptor expressed on myeloid cells 2 and glial fibrillary acidic protein levels). We performed multivariable regression models to investigate the associations of linear biomarkers and sociodemographic factors with HADS scores during the confinementpre-pandemic AD-related. . Finally, we explored the role of stress and lifestyle changes (sleep patterns, eating, drinking, smoking habits, and medication use) on the tested associations and performed sex-stratified analyses.We further performed an analysis of covariance in order to adjust by participants' pre-pandemic anxiety-depression levels\n\nWe included 921 (254 with AD biomarkers) participants. Amyloid-\u03b2 positivity (B=3.73; 95%CI=1.1 to 6.36; p=.006), caregiving (B=1.37; 95%CI=0.24 to 2.5; p=.018), sex (women: B=1.95; 95%CI=1.1 to 2.79; p<.001), younger age (B=-0.12; 95%CI=-0.18 to -0.052; p<.001) and lower education (B=-0.16; 95%CI=-0.28 to -0.042; p=.008) were associated with greater anxious-depressive symptoms during the confinement. Considering pre-pandemic anxiety-depression levels, we further observed an association between (B=-5.11; 95%CI=-10.1 to -0.13; lower levels of CSF IL-6p=.044) and HADS scores. The results were independent of stress-related variables and lifestyle changes. Stratified analysis revealed that the associations were mainly driven by women.greater\n\nOur results link AD-related pathophysiology and neuroinflammation with anxious-depressive symptomatology during the COVID-19-related confinement, notably in women. AD pathophysiology may increase neuropsychiatric symptomatology in response to stressors. This association may imply a worse clinical prognosis in people at risk for AD after the pandemic, and thus deserves to be considered by clinicians.greater\n\nClinicalTrials.gov Identifier NCT02485730.", "doi": "10.1212/WNL.0000000000200948", "pmid": "35918160", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "WNL.0000000000200948"}, {"db": "ClinicalTrials.gov", "key": "NCT02485730"}], "notes": [], "created": "2022-08-11T12:02:17.685Z", "modified": "2022-08-11T12:02:17.790Z"}, {"entity": "publication", "iuid": "2cbd31a1040043d09247c2097750ee5e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2cbd31a1040043d09247c2097750ee5e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2cbd31a1040043d09247c2097750ee5e"}}, "title": "Lockdown and No Lockdown: How Norwegian and Swedish Elite Athletes Managed Preparations for Tokyo 2020 and Mental Health Challenges in the Shadow of COVID-19.", "authors": [{"family": "Lundqvist", "given": "Carolina", "initials": "C"}, {"family": "Kristiansen", "given": "Elsa", "initials": "E"}], "type": "journal article", "published": "2022-08-02", "journal": {"title": "Front Sports Act Living", "issn": "2624-9367", "volume": "4", "pages": "918825", "issn-l": null}, "abstract": "The present study explored Norwegian and Swedish Olympic aspirants' perceived challenges for the preparations of Tokyo 2020 Olympic Games (OG) and risk and protective factors for mental health. The focus for this study was the timespan between the declaration of the postponement of Tokyo 2020 and the final months before the Games. A secondary purpose was to explore experiences of both elite athletes affected by lockdown (i.e., Norwegian athletes) and elite athletes not affected by lockdown in their home country (i.e., Swedish athletes). Twelve elite athletes (Norwegian: n = 6; Swedish: n = 6; Women: n = 6; Men: n = 6) with a mean age of 28.25 (SD = 3.60) participated. Semi-structured interviews were conducted between April and June 2021. Seven athletes had qualified and five were still trying to qualify. Eight of the interviewed athletes had previous experiences with OG participation. Template analysis revealed two main themes: (a) challenges and risk-factors for mental health and (b) protective factors. The pandemic exposed athletes to several psychological strains like uncertainty and difficulties with planning and preparations for the OG and personal and social challenges (i.e., worry about physical health and risk of overtraining, social contacts, identity, and life issues). Protective factors included perceived benefits of increased recovery and time for quality training. The athletes used several coping strategies and self-care behaviors (e.g., focus on the controllable, playfulness, putting sports in perspective, daily routines, short-term goals, working or studying for personal development) and they tapped into various internal and external psychosocial resources perceived as protective for mental health, personal growth, resiliency, and adjustment to the pandemic. The holistic perspectives used contribute to an increased understanding of elite sport athletes' mental health needs in stressful and unforeseen situations such as a pandemic.", "doi": "10.3389/fspor.2022.918825", "pmid": "35982760", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9378964"}], "notes": [], "created": "2022-09-12T18:45:36.583Z", "modified": "2022-09-12T18:45:36.595Z"}, {"entity": "publication", "iuid": "31f243e37ec049429d996fc9718824f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/31f243e37ec049429d996fc9718824f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/31f243e37ec049429d996fc9718824f7"}}, "title": "Increased incidence of childhood type 1 diabetes during the COVID-19 pandemic. Figures from an Italian tertiary care center.", "authors": [{"family": "Schiaffini", "given": "Riccardo", "initials": "R", "orcid": "0000-0002-9527-2353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5246b36ef614d9fb2ceb112e0cd80ba.json"}}, {"family": "Deodati", "given": "Annalisa", "initials": "A"}, {"family": "Rapini", "given": "Novella", "initials": "N"}, {"family": "Pampanini", "given": "Valentina", "initials": "V"}, {"family": "Cianfarani", "given": "Stefano", "initials": "S"}], "type": "letter", "published": "2022-08-02", "journal": {"title": "J Diabetes", "issn": "1753-0407", "issn-l": null}, "abstract": null, "doi": "10.1111/1753-0407.13298", "pmid": "35916392", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-11T12:02:59.090Z", "modified": "2022-08-11T12:02:59.148Z"}, {"entity": "publication", "iuid": "115d909766f44e4db43983d9bbdeb689", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/115d909766f44e4db43983d9bbdeb689.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/115d909766f44e4db43983d9bbdeb689"}}, "title": "Computational models predicting the early development of the COVID-19 pandemic in Sweden: systematic review, data synthesis, and secondary validation of accuracy", "authors": [{"family": "Gerlee", "given": "Philip", "initials": "P", "orcid": "0000-0001-8503-0177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ba426c1ab741e781d2b9cd09a0b830.json"}}, {"family": "J\u00f6ud", "given": "Anna", "initials": "A", "orcid": "0000-0001-7192-4911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e038a5ce2f5a47bd89e7c221651a3d24.json"}}, {"family": "Spreco", "given": "Armin", "initials": "A"}, {"family": "Timpka", "given": "Toomas", "initials": "T"}], "type": "journal-article", "published": "2022-08-02", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "13256", "issn-l": "2045-2322"}, "abstract": "Computational models for predicting the early course of the COVID-19 pandemic played a central role in policy-making at regional and national levels. We performed a systematic review, data synthesis, and secondary validation of studies that reported on prediction models addressing the early stages of the COVID-19 pandemic in Sweden. A literature search in January 2021 based on the search triangle model identified 1672 peer-reviewed articles, preprints and reports. After applying inclusion criteria 52 studies remained out of which 12 passed a Risk of Bias Opinion Tool. When comparing model predictions with actual outcomes only 4 studies exhibited an acceptable forecast (mean absolute percentage error, MAPE < 20%). Models that predicted disease incidence could not be assessed due to the lack of reliable data during 2020. Drawing conclusions about the accuracy of the models with acceptable methodological quality was challenging because some models were published before the time period for the prediction, while other models were published during the prediction period or even afterwards. We conclude that the forecasting models involving Sweden developed during the early stages of the COVID-19 pandemic in 2020 had limited accuracy. The knowledge attained in this study can be used to improve the preparedness for coming pandemics.", "doi": "10.1038/s41598-022-16159-6", "pmid": "35918476", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9345013"}, {"db": "pii", "key": "10.1038/s41598-022-16159-6"}], "notes": [], "created": "2022-08-11T12:01:58.698Z", "modified": "2023-06-19T14:58:56.393Z"}, {"entity": "publication", "iuid": "c3a29385ba7848e4b7dae4b8db98a818", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3a29385ba7848e4b7dae4b8db98a818.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3a29385ba7848e4b7dae4b8db98a818"}}, "title": "The Role of Neutrophil-to-Lymphocyte Ratio in Risk Stratification and Prognostication of COVID-19: A Systematic Review and Meta-Analysis.", "authors": [{"family": "Parthasarathi", "given": "Ashwaghosha", "initials": "A", "orcid": "0000-0002-7270-0247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c0a5e6837a421cbbb0314628ae7f24.json"}}, {"family": "Padukudru", "given": "Sunag", "initials": "S", "orcid": "0000-0003-4088-9548", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/815e161a476946c689f312fd8986b5a0.json"}}, {"family": "Arunachal", "given": "Sumalata", "initials": "S"}, {"family": "Basavaraj", "given": "Chetak Kadabasal", "initials": "CK"}, {"family": "Krishna", "given": "Mamidipudi Thirumala", "initials": "MT", "orcid": "0000-0003-2109-5777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cfbac9ab1b3c4afea2f7de6b60fd162a.json"}}, {"family": "Ganguly", "given": "Koustav", "initials": "K", "orcid": "0000-0001-8531-8154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58b2e0d7853a4b32920e54042e95061d.json"}}, {"family": "Upadhyay", "given": "Swapna", "initials": "S"}, {"family": "Anand", "given": "Mahesh Padukudru", "initials": "MP"}], "type": "journal article", "published": "2022-08-01", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "Several studies have proposed that the neutrophil-lymphocyte ratio (NLR) is one of the various biomarkers that can be useful in assessing COVID-19 disease-related outcomes. Our systematic review analyzes the relationship between on-admission NLR values and COVID-19 severity and mortality. Six different severity criteria were used. A search of the literature in various databases was conducted from 1 January 2020 to 1 May 2021. We calculated the pooled standardized mean difference (SMD) for the collected NLR values. A meta-regression analysis was performed, looking at the length of hospitalization and other probable confounders, such as age, gender, and comorbidities. A total of sixty-four studies were considered, which included a total of 15,683 patients. The meta-analysis showed an SMD of 3.12 (95% CI: 2.64-3.59) in NLR values between severe and non-severe patients. A difference of 3.93 (95% CI: 2.35-5.50) was found between survivors and non-survivors of the disease. Upon summary receiver operating characteristics analysis, NLR showed 80.2% (95% CI: 74.0-85.2%) sensitivity and 75.8% (95% CI: 71.3-79.9%) specificity for the prediction of severity and 78.8% (95% CI: 73.5-83.2%) sensitivity and 73.0% (95% CI: 68.4-77.1%) specificity for mortality, and was not influenced by age, gender, or co-morbid conditions. Conclusion: On admission, NLR predicts both severity and mortality in COVID-19 patients, and an NLR &gt; 6.5 is associated with significantly greater the odds of mortality.", "doi": "10.3390/vaccines10081233", "pmid": "36016121", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "vaccines10081233"}, {"db": "pmc", "key": "PMC9415708"}], "notes": [], "created": "2022-09-12T19:11:18.061Z", "modified": "2022-09-12T19:11:18.188Z"}, {"entity": "publication", "iuid": "f6ab87d2afb44facbaa5e35b6a5dcb4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6ab87d2afb44facbaa5e35b6a5dcb4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6ab87d2afb44facbaa5e35b6a5dcb4d"}}, "title": "Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia.", "authors": [{"family": "Zhang", "given": "Qian", "initials": "Q", "orcid": "0000-0002-9040-3289", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/341c0cb0fa7d41448e55344c82d68358.json"}}, {"family": "Matuozzo", "given": "Daniela", "initials": "D", "orcid": "0000-0001-9514-3837", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f3ea98ae5ed468a81d92fd3c5d4782b.json"}}, {"family": "Le Pen", "given": "J\u00e9r\u00e9mie", "initials": "J", "orcid": "0000-0001-7025-9526", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/419c9219d4664b899addbcdde33b7551.json"}}, {"family": "Lee", "given": "Danyel", "initials": "D", "orcid": "0000-0003-3124-0245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a658026d0b444541bc6fa15b1de790ec.json"}}, {"family": "Moens", "given": "Leen", "initials": "L", "orcid": "0000-0002-5347-6526", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49147a953e1c4721bd0181e5d0a3dafb.json"}}, {"family": "Asano", "given": "Takaki", "initials": "T", "orcid": "0000-0003-1424-2433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cce1fe0e7df44b2a7a49fbcb45b1a5a.json"}}, {"family": "Bohlen", "given": "Jonathan", "initials": "J", "orcid": "0000-0003-0458-9484", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9aedda86e36413883cc6558c66727e1.json"}}, {"family": "Liu", "given": "Zhiyong", "initials": "Z", "orcid": "0000-0001-6473-348X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d7b2869a5874679b1b6fdccade088a2.json"}}, {"family": "Moncada-Velez", "given": "Marcela", "initials": "M", "orcid": "0000-0002-3073-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c543a8539a6430b8ff5cd9cf5875bf9.json"}}, {"family": "Kendir-Demirkol", "given": "Yasemin", "initials": "Y", "orcid": "0000-0001-8016-5224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d48a0443bd049bea3e4ab80b48239c3.json"}}, {"family": "Jing", "given": "Huie", "initials": "H", "orcid": "0000-0001-6283-3452", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8904017c1a114ad7aa4a64850450f299.json"}}, {"family": "Bizien", "given": "Lucy", "initials": "L", "orcid": "0000-0001-9163-9122", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ffde5891cfed41db9dc0265155576cc4.json"}}, {"family": "Marchal", "given": "Astrid", "initials": "A", "orcid": "0000-0003-0648-8126", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbf87e3c4eb34dadb828c6f58276e8b0.json"}}, {"family": "Abolhassani", "given": "Hassan", "initials": "H", "orcid": "0000-0002-4838-0407", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36fb362d046748b0a62822960ce20edd.json"}}, {"family": "Delafontaine", "given": "Selket", "initials": "S", "orcid": "0000-0002-8985-8155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/505e15f7fd9e41d3b3f3a9fa8bb3a123.json"}}, {"family": "Bucciol", "given": "Giorgia", "initials": "G", "orcid": "0000-0001-5004-0738", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fde316a981d84407a32dca71fd6f39ba.json"}}, {"family": "COVID Human Genetic Effort", "given": "", "initials": ""}, {"family": "Bayhan", "given": "Gulsum Ical", "initials": "GI", "orcid": "0000-0002-1423-4348", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/974e5811368646b5a90ccc027212db3d.json"}}, {"family": "Keles", "given": "Sevgi", "initials": "S", "orcid": "0000-0001-7344-8947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08e51d507698439cbf08326d10be2310.json"}}, {"family": "Kiykim", "given": "Ayca", "initials": "A", "orcid": "0000-0001-5821-3963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/999518defe2c4fabb42480ccef8ad8c0.json"}}, {"family": "Hancerli", "given": "Selda", "initials": "S", "orcid": "0000-0002-3216-2413", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7414c31e5b704991a1e81912d14eddc8.json"}}, {"family": "Haerynck", "given": "Filomeen", "initials": "F", "orcid": "0000-0001-9161-7361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbe7ce932ab14405b7ad1c1153d39972.json"}}, {"family": "Florkin", "given": "Benoit", "initials": "B", "orcid": "0000-0001-7318-8348", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc4ebf10fd104544803675f66863291b.json"}}, {"family": "Hatipoglu", "given": "Nevin", "initials": "N", "orcid": "0000-0003-2858-0150", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c14f98b8f5e24280a669fa49a297c3dc.json"}}, {"family": "Ozcelik", "given": "Tayfun", "initials": "T", "orcid": "0000-0001-5937-1082", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6665d35db77044aa847a5f394332bb86.json"}}, {"family": "Morelle", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-6511-1674", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0ef829b533e45edb15a3e5c03c2db65.json"}}, {"family": "Zatz", "given": "Mayana", "initials": "M", "orcid": "0000-0003-3970-8025", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d37e5fa0191b433386921fff2e34245b.json"}}, {"family": "Ng", "given": "Lisa F P", "initials": "LFP", "orcid": "0000-0003-4071-5222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0502452f11bf44ba96a6cb952a82a1f5.json"}}, {"family": "Lye", "given": "David Chien", "initials": "DC", "orcid": "0000-0003-0324-0205", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d274935e03904ae2935f07246404d97d.json"}}, {"family": "Young", "given": "Barnaby Edward", "initials": "BE", "orcid": "0000-0003-1010-2230", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/319b1cd3f3b540edb9f9651160eefcb3.json"}}, {"family": "Leo", "given": "Yee-Sin", "initials": "YS", "orcid": "0000-0003-4978-5825", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ca28661a9df44a7b95577da156b54c9.json"}}, {"family": "Dalgard", "given": "Clifton L", "initials": "CL", "orcid": "0000-0003-2025-8239", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22f57b7602714f59bfbcc96a936d77a8.json"}}, {"family": "Lifton", "given": "Richard P", "initials": "RP", "orcid": "0000-0002-5745-5984", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/354dc2abf2a04896b69ef5cba011679f.json"}}, {"family": "Renia", "given": "Laurent", "initials": "L", "orcid": "0000-0003-0349-1557", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/957c86bd7cc941e0a2e7c7de9817e5ce.json"}}, {"family": "Meyts", "given": "Isabelle", "initials": "I", "orcid": "0000-0003-1214-0302", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a5399449f4c4d338b683632944008fb.json"}}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E", "orcid": "0000-0002-7358-9157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c50d261245743539a5813daffcaab72.json"}}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L", "orcid": "0000-0002-8635-9609", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b532108235c415891981621f58ddbfd.json"}}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q", "orcid": "0000-0003-1990-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94a32366862b470eba3a15521b9be290.json"}}, {"family": "Boisson", "given": "Bertrand", "initials": "B", "orcid": "0000-0001-5240-3555", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1dc2dc22a5d240dc889707226eb18a36.json"}}, {"family": "Bastard", "given": "Paul", "initials": "P", "orcid": "0000-0002-5926-8437", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e3388c840d04a25824530a9bf999f01.json"}}, {"family": "Su", "given": "Helen C", "initials": "HC", "orcid": "0000-0002-5582-9110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad550813f03540d9a8240a3d96ad0829.json"}}, {"family": "Boisson-Dupuis", "given": "St\u00e9phanie", "initials": "S", "orcid": "0000-0002-7115-116X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92c785f151bb490aa85764eb62c0508e.json"}}, {"family": "Abel", "given": "Laurent", "initials": "L", "orcid": "0000-0001-7016-6493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fd6c4593c8c492a8dad8e49cb7a832a.json"}}, {"family": "Rice", "given": "Charles M", "initials": "CM", "orcid": "0000-0003-3087-8079", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb21eff3730f4b64a8ebed8b04a9038c.json"}}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY", "orcid": "0000-0002-9449-3672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/273e17cf54524572baff11761631d846.json"}}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5369fe152ac94b5a81d4f913d85940a7.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL", "orcid": "0000-0002-7782-4169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1aca66ab7c39465faf2de03fa8a6722f.json"}}], "type": "journal article", "published": "2022-08-01", "journal": {"title": "J Exp Med", "issn": "1540-9538", "volume": "219", "issue": "8", "issn-l": null}, "abstract": "Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical COVID-19 pneumonia in unvaccinated adults. The risk of COVID-19 pneumonia in unvaccinated children, which is much lower than in unvaccinated adults, remains unexplained. In an international cohort of 112 children (<16 yr old) hospitalized for COVID-19 pneumonia, we report 12 children (10.7%) aged 1.5-13 yr with critical (7 children), severe (3), and moderate (2) pneumonia and 4 of the 15 known clinically recessive and biochemically complete inborn errors of type I IFN immunity: X-linked recessive TLR7 deficiency (7 children) and autosomal recessive IFNAR1 (1), STAT2 (1), or TYK2 (3) deficiencies. Fibroblasts deficient for IFNAR1, STAT2, or TYK2 are highly vulnerable to SARS-CoV-2. These 15 deficiencies were not found in 1,224 children and adults with benign SARS-CoV-2 infection without pneumonia (P = 1.2 \u00d7 10-11) and with overlapping age, sex, consanguinity, and ethnicity characteristics. Recessive complete deficiencies of type I IFN immunity may underlie \u223c10% of hospitalizations for COVID-19 pneumonia in children.", "doi": "10.1084/jem.20220131", "pmid": "35708626", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "213287"}, {"db": "pmc", "key": "PMC9206114"}], "notes": [], "created": "2022-06-20T18:08:01.020Z", "modified": "2022-08-17T12:48:34.870Z"}, {"entity": "publication", "iuid": "6deffae81fdc4c21bf7b2b1d630eff8f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6deffae81fdc4c21bf7b2b1d630eff8f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6deffae81fdc4c21bf7b2b1d630eff8f"}}, "title": "Pharmacovigilance regulatory actions by national pharmacovigilance centres in Arab countries following COVID-19 pandemic.", "authors": [{"family": "Al-Zubiedi", "given": "Sameh A", "initials": "SA", "orcid": "0000-0003-0888-5328", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/686c3af4ef524cdfbcedbae63dba9c77.json"}}, {"family": "Younus", "given": "Manal", "initials": "M"}, {"family": "Al-Khalidi", "given": "Sara", "initials": "S"}, {"family": "Ekilo", "given": "Magnus", "initials": "M"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM", "orcid": "0000-0002-5630-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5162aab03bc04dafa809108461f18667.json"}}], "type": "journal article", "published": "2022-08-01", "journal": {"title": "Expert Opin Drug Saf", "issn": "1744-764X", "issn-l": null}, "abstract": "Pharmacovigilance (PV) activities were affected by COVID-19. Therefore, several health authorities around the world have issued guidelines and practices to ensure that PV activities are maintained and continued during the pandemic. This study aimed to assess the impact of COVID-19 on the preparedness and performance of national PV systems in 14 Arab countries.\n\nThis was a cross-sectional study that was conducted between July and October 2020. National PV centres in 18 Arab countries were invited to participate in this study. Descriptive analysis was used to summarize and present the results of this study.\n\nResponses were obtained from 14 (77.8%) countries. Adverse events reporting was the main PV activity that was covered by PV guidelines and practices. National guidelines and practices covered other PV activities in 8 (57.14%) of the participating countries. Performance and practices of national PV centres vary considerably among participating countries during the pandemic.\n\nThe findings highlight the differences in preparedness and performance of different national PV centres in participating Arab countries. Improving digital infrastructure among participating countries could serve as a useful tool to minimize the impact of the pandemic on PV activities.", "doi": "10.1080/14740338.2022.2108398", "pmid": "35915555", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-08-11T12:03:26.248Z", "modified": "2022-08-11T12:03:26.339Z"}, {"entity": "publication", "iuid": "736b58cbf52142a6926bd2b650b86d2b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/736b58cbf52142a6926bd2b650b86d2b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/736b58cbf52142a6926bd2b650b86d2b"}}, "title": "Ion channel inhibition with amiodarone or verapamil in symptomatic hospitalized nonintensive-care COVID-19 patients: The ReCOVery-SIRIO randomized trial.", "authors": [{"family": "Navarese", "given": "Eliano P", "initials": "EP"}, {"family": "Podhajski", "given": "Przemys\u0142aw", "initials": "P"}, {"family": "Andreotti", "given": "Felicita", "initials": "F"}, {"family": "La Torre", "given": "Giuseppe", "initials": "G"}, {"family": "Gajda", "given": "Robert", "initials": "R"}, {"family": "Radziwanowski", "given": "Adrian", "initials": "A"}, {"family": "Nowicka", "given": "Ma\u0142gorzata", "initials": "M"}, {"family": "Bukowski", "given": "Pawe\u0142", "initials": "P"}, {"family": "Gajda", "given": "Jacek", "initials": "J"}, {"family": "Omy\u0142a", "given": "Maciej", "initials": "M"}, {"family": "Lackowski", "given": "Piotr", "initials": "P"}, {"family": "Piasecki", "given": "Maciej", "initials": "M"}, {"family": "Jasiewicz", "given": "Ma\u0142gorzata", "initials": "M"}, {"family": "Szyma\u0144ski", "given": "Pawe\u0142", "initials": "P"}, {"family": "Pietrzykowski", "given": "\u0141ukasz", "initials": "\u0141"}, {"family": "Michalski", "given": "Piotr", "initials": "P"}, {"family": "Kubica", "given": "Aldona", "initials": "A"}, {"family": "Urbanowicz", "given": "Iwona", "initials": "I"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}, {"family": "Conte", "given": "Max", "initials": "M"}, {"family": "Pinkas", "given": "Jaros\u0142aw", "initials": "J"}, {"family": "Brouwer", "given": "Marc A", "initials": "MA"}, {"family": "Kubica", "given": "Jacek", "initials": "J"}], "type": "journal article", "published": "2022-08-01", "journal": {"title": "Cardiol J", "issn": "1898-018X", "issn-l": null}, "abstract": "Ion channel inhibition may offer protection against coronavirus disease 2019 (COVID-19). Inflammation and reduced platelet count occur during COVID-19 but precise quantification of risk thresholds is unclear. The Recovery-SIRIO study aimed to assess clinical effects of amiodarone and verapamil and to relate patient phenotypes to outcomes.\n\nRECOVERY-SIRIO is a multicenter open-label 1:1:1 investigator-initiated randomized trial with blinded event adjudication. A sample of 804 symptomatic hospitalized nonintensive-care COVID-19 patients, follow-up for 28 days was initially planned.\n\nThe trial was stopped when a total of 215 patients had been randomized to amiodarone (n = 71), verapamil (n = 72) or standard care alone (n = 72). At 15 days, the hazard ratio (hazard ratio [HR], 95% confidence interval [CI]) for clinical improvement was 0.77 (0.52-1.14) with amiodarone and 0.97 (0.81-1.17) with verapamil as compared to usual care. Clinically relevant associations were found between mortality or lack of clinical improvement and higher peak C-reactive protein (CRP) levels or nadir platelet count at 7, 10 and 15 days. Mortality rate increased by 73% every 5 mg/dL increment in peak CRP (HR 1.73, 95% CI 1.27-2.37) and was two-fold higher for every decrement of 100 units in nadir platelet count (HR 2.19, 95% CI 1.37-3.51). By cluster analysis, thresholds of 5 mg/dL for peak CRP and 187 \u00d710\u00b3/mcL for nadir platelet count identified the phenogroup at greatest risk of dying.\n\nIn this randomized trial, neither amiodarone nor verapamil were found to significantly accelerate short-term clinical improvement. Peak CRP and nadir platelet counts were associated with increased mortality both in isolation and by cluster analysis.", "doi": "10.5603/CJ.a2022.0072", "pmid": "35912711", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "VM/OJS/J/88627"}], "notes": [], "created": "2022-08-11T12:04:30.224Z", "modified": "2022-08-11T12:04:30.261Z"}, {"entity": "publication", "iuid": "c74a65a0291343bcb2edbb2ba2f7f3c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c74a65a0291343bcb2edbb2ba2f7f3c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c74a65a0291343bcb2edbb2ba2f7f3c0"}}, "title": "Can aerosols-generating dental, oral and maxillofacial, and orthopedic surgical procedures lead to disease transmission? An implication on the current COVID-19 pandemic.", "authors": [{"family": "Al-Moraissi", "given": "Essam Ahmed", "initials": "EA"}, {"family": "Kaur", "given": "Amanjot", "initials": "A"}, {"family": "G\u00fcnther", "given": "Frank", "initials": "F"}, {"family": "Neff", "given": "Andreas", "initials": "A"}, {"family": "Christidis", "given": "Nikolaos", "initials": "N"}], "type": "systematic review", "published": "2022-08-01", "journal": {"title": "Front Oral Health", "issn": "2673-4842", "volume": "3", "pages": "974644", "issn-l": null}, "abstract": "Various dental, maxillofacial, and orthopedic surgical procedures (DMOSP) have been known to produce bioaerosols, that can lead to the transmission of various infectious diseases. Hence, a systematic review (SR) aimed at generating evidence of aerosols generating DMOSP that can result in the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), further investigating their infectivity and assessing the role of enhanced personal protective equipment (PPE) an essential to preventing the spreading of SARS-CoV-2 during aerosol-generating procedures (AGPs). This SR was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (PRISMA) guidelines based on a well-designed Population, Intervention, Comparison, Outcomes and Study (PICOS) framework, and various databases were searched to retrieve the studies which assessed potential aerosolization during DMOSP. This SR included 80 studies (59 dental and 21 orthopedic) with 7 SR, 47 humans, 5 cadaveric, 16 experimental, and 5 animal studies that confirmed the generation of small-sized < 5 \u03bcm particles in DMOSP. One study confirmed that HIV could be transmitted by aerosolized blood generated by an electric saw and bur. There is sufficient evidence that DMOSP generates an ample amount of bioaerosols, but the infectivity of these bioaerosols to transmit diseases like SARS-CoV-2 generates very weak evidence but still, this should be considered. Confirmation through isolation and culture of viable virus in the clinical environment should be pursued. An evidence provided by the current review was gathered by extrapolation from available experimental and empirical evidence not based on SARS-CoV-2. The results of the present review, therefore, should be interpreted with great caution.", "doi": "10.3389/froh.2022.974644", "pmid": "35979536", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9376374"}], "notes": [], "created": "2022-09-12T18:41:22.127Z", "modified": "2022-09-12T18:41:32.412Z"}, {"entity": "publication", "iuid": "6c5019a8ad1f4e78beb9ad8e3f80fb4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c5019a8ad1f4e78beb9ad8e3f80fb4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c5019a8ad1f4e78beb9ad8e3f80fb4d"}}, "title": "Acute pericarditis in patients receiving coronavirus disease 2019 vaccines: a case series from the community.", "authors": [{"family": "Dini", "given": "Frank L", "initials": "FL"}, {"family": "Franzoni", "given": "Ferdinando", "initials": "F"}, {"family": "Scarf\u00f2", "given": "Giorgia", "initials": "G"}, {"family": "Pugliese", "given": "Nicola Riccardo", "initials": "NR"}, {"family": "Imazio", "given": "Massimo", "initials": "M"}], "type": "journal article", "published": "2022-08-01", "journal": {"title": "J Cardiovasc Med (Hagerstown)", "issn": "1558-2035", "volume": "23", "issue": "8", "pages": "551-558", "issn-l": null}, "abstract": "International agencies reported that cases of pericarditis occur very rarely following the administration of coronavirus disease 2019 (COVID-19) vaccines. Herewith, we described a series of patients from the community diagnosed with acute pericarditis after vaccination.\n\nWe retrospectively included 28 patients (median age 51 years, 79% female) with or without a positive history of acute respiratory syndrome coronavirus 2 recovered infection who were diagnosed with acute pericarditis following the administration of COVID-19 vaccine. We excluded specific identifiable causes of pericarditis, including infectious, autoimmune, neoplastic and metabolic disease. Patients were referred for a complete cardiovascular evaluation. Transthoracic echocardiography (TTE) was performed and diagnosis of acute pericarditis was achieved according to current guidelines.\n\nThere were 16 patients administered with Pfizer-BioNTech/Comirnaty vaccine, 8 with Moderna/Spikevax vaccine and 4 with Astra Zeneca/Vaxzevria vaccine. Nine patients had been previously diagnosed with COVID-19, while the others had no prior history of COVID-19. Eleven patients had no comorbidity while the others had between one and four comorbidities. Ten patients had a history of rheumatic or autoimmune diseases. Chest pain was present in 24 patients. Minor ECG abnormalities were detected in 10 patients, T-wave inversion in 6, and 7 patients had concave ST elevation. The majority of patients showed mild pericardial effusions at TTE. Only two patients exhibited large pericardial effusions.\n\nThis case series shows a higher incidence of acute pericarditis in patients administered with COVID-19 vaccines than previously estimated, probably because of a more comprehensive assessment of clinical as well as echocardiographic parameters.", "doi": "10.2459/JCM.0000000000001342", "pmid": "35904995", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "01244665-990000000-00028"}], "notes": [], "created": "2022-08-12T08:31:22.928Z", "modified": "2022-08-12T08:31:22.933Z"}, {"entity": "publication", "iuid": "68b51851f33c4f63b18049d8f560ce50", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68b51851f33c4f63b18049d8f560ce50.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68b51851f33c4f63b18049d8f560ce50"}}, "title": "Zanubrutinib versus bendamustine and rituximab in untreated chronic lymphocytic leukaemia and small lymphocytic lymphoma (SEQUOIA): a randomised, controlled, phase 3 trial.", "authors": [{"family": "Tam", "given": "Constantine S", "initials": "CS"}, {"family": "Brown", "given": "Jennifer R", "initials": "JR"}, {"family": "Kahl", "given": "Brad S", "initials": "BS"}, {"family": "Ghia", "given": "Paolo", "initials": "P"}, {"family": "Giannopoulos", "given": "Krzysztof", "initials": "K"}, {"family": "Jurczak", "given": "Wojciech", "initials": "W"}, {"family": "\u0160imkovi\u010d", "given": "Martin", "initials": "M"}, {"family": "Shadman", "given": "Mazyar", "initials": "M"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Laurenti", "given": "Luca", "initials": "L"}, {"family": "Walker", "given": "Patricia", "initials": "P"}, {"family": "Opat", "given": "Stephen", "initials": "S"}, {"family": "Chan", "given": "Henry", "initials": "H"}, {"family": "Ciepluch", "given": "Hanna", "initials": "H"}, {"family": "Greil", "given": "Richard", "initials": "R"}, {"family": "Tani", "given": "Monica", "initials": "M"}, {"family": "Trn\u011bn\u00fd", "given": "Marek", "initials": "M"}, {"family": "Brander", "given": "Danielle M", "initials": "DM"}, {"family": "Flinn", "given": "Ian W", "initials": "IW"}, {"family": "Grosicki", "given": "Sebastian", "initials": "S"}, {"family": "Verner", "given": "Emma", "initials": "E"}, {"family": "Tedeschi", "given": "Alessandra", "initials": "A"}, {"family": "Li", "given": "Jianyong", "initials": "J"}, {"family": "Tian", "given": "Tian", "initials": "T"}, {"family": "Zhou", "given": "Lei", "initials": "L"}, {"family": "Marimpietri", "given": "Carol", "initials": "C"}, {"family": "Paik", "given": "Jason C", "initials": "JC"}, {"family": "Cohen", "given": "Aileen", "initials": "A"}, {"family": "Huang", "given": "Jane", "initials": "J"}, {"family": "Robak", "given": "Tadeusz", "initials": "T"}, {"family": "Hillmen", "given": "Peter", "initials": "P"}], "type": "clinical trial, phase iii", "published": "2022-08-00", "journal": {"title": "Lancet Oncol", "issn": "1474-5488", "volume": "23", "issue": "8", "pages": "1031-1043", "issn-l": null}, "abstract": "Zanubrutinib is a next-generation, selective Bruton tyrosine kinase inhibitor with efficacy in relapsed chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). We compared zanubrutinib with bendamustine-rituximab to determine its effectiveness as frontline therapy in patients with CLL or SLL.\n\nWe conducted an open-label, multicentre, phase 3 study at 153 academic or community hospitals in 14 countries and regions. Eligible patients had untreated CLL or SLL requiring treatment as per International Workshop on CLL criteria; were aged 65 years or older, or 18 years or older and had comorbidities; and had an Eastern Cooperative Oncology Group performance status score of 0-2. A central interactive web response system randomly assigned patients without del(17)(p13\u00b71) to zanubrutinib (group A) or bendamustine-rituximab (group B) by sequential block method (permutated blocks with a random block size of four). Patients with del(17)(p13\u00b71) were enrolled in group C and received zanubrutinib. Zanubrutinib was administered orally at 160 mg twice per day (28-day cycles); bendamustine at 90 mg/m2 of body surface area on days 1 and 2 for six cycles plus rituximab at 375 mg/m2 of body surface area the day before or on day 1 of cycle 1, and 500 mg/m2 of body surface area on day 1 of cycles 2-6, were administered intravenously. The primary endpoint was progression-free survival per independent review committee in the intention-to-treat population in groups A and B, with minimum two-sided \u03b1 of 0\u00b705 for superiority. Safety was analysed in all patients who received at least one dose of study treatment. The study is registered with ClinicalTrials.gov, NCT03336333, and is closed to recruitment.\n\nBetween Oct 31, 2017, and July 22, 2019, 590 patients were enrolled; patients without del(17)(p13\u00b71) were randomly assigned to zanubrutinib (group A; n=241) or bendamustine-rituximab (group B; n=238). At median follow-up of 26\u00b72 months (IQR 23\u00b77-29\u00b76), median progression-free survival per independent review committee was not reached in either group (group A 95% CI not estimable [NE] to NE; group B 28\u00b71 months to NE). Progression-free survival was significantly improved in group A versus group B (HR 0\u00b742 [95% CI 0\u00b728 to 0\u00b763]; two-sided p<0\u00b70001). The most common grade 3 or worse adverse event was neutropenia (27 [11%] of 240 patients in group A, 116 [51%] of 227 in group B, and 17 [15%] of 111 patients in group C). Serious adverse events occurred in 88 (37%) of 240 patients in group A, 113 (50%) of 227 patients in group B, and 45 (41%) of 111 patients in group C. Adverse events leading to death occurred in 11 (5%) of 240 patients in group A, 12 (5%) of 227 patients in group B, and three (3%) of 111 patients in group C, most commonly due to COVID-19 (four [2%] of 240 patients in group A), diarrhoea, and aspiration pneumonia (two each [1%] of 227 patients in group B).\n\nZanubrutinib significantly improved progression-free survival versus bendamustine-rituximab, with an acceptable safety profile consistent with previous studies. These data support zanubrutinib as a potential new treatment option for untreated CLL and SLL.\n\nBeiGene.", "doi": "10.1016/S1470-2045(22)00293-5", "pmid": "35810754", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1470-2045(22)00293-5"}, {"db": "ClinicalTrials.gov", "key": "NCT03336333"}], "notes": [], "created": "2022-08-17T10:39:58.703Z", "modified": "2022-08-17T10:39:58.741Z"}, {"entity": "publication", "iuid": "0e5238a4af7444efb0b085cb8e289129", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e5238a4af7444efb0b085cb8e289129.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e5238a4af7444efb0b085cb8e289129"}}, "title": "Young children's voices in an unlocked Sweden during the COVID-19 pandemic.", "authors": [{"family": "Jenholt Nolbris", "given": "M", "initials": "M", "orcid": "0000-0002-6911-1484", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f53d9c5dc5ff46149ef63e16dfa6d7a1.json"}}, {"family": "Ragnarsson", "given": "S", "initials": "S", "orcid": "0000-0002-0646-7184", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44ffe0f652d74510b8caa74f9fb1c01f.json"}}, {"family": "Brorsson", "given": "A-L", "initials": "AL", "orcid": "0000-0002-8136-6340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bdee85ca7c74d93a2881e22997192b7.json"}}, {"family": "Garcia de Avila", "given": "M", "initials": "M", "orcid": "0000-0002-6652-4427", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b1e6b2121ac40969728034efca6c6a9.json"}}, {"family": "Forsner", "given": "M", "initials": "M"}, {"family": "Kull", "given": "I", "initials": "I"}, {"family": "Olinder", "given": "A L", "initials": "AL"}, {"family": "Mattson", "given": "J", "initials": "J"}, {"family": "Nilsson", "given": "S", "initials": "S"}, {"family": "Rullander", "given": "A-C", "initials": "AC"}, {"family": "Rydstr\u00f6m", "given": "L-L", "initials": "LL", "orcid": "0000-0002-1007-1959", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad5251de283d4f73b0c2ac600a34a19a.json"}}, {"family": "Olaya-Contreras", "given": "P", "initials": "P"}, {"family": "Berghammer", "given": "M", "initials": "M"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "volume": "50", "issue": "6", "pages": "693-702", "issn-l": "1403-4948"}, "abstract": "During the COVID-19 pandemic, Sweden was one of the few countries that rejected lockdowns in favour of recommendations for restrictions, including careful hand hygiene and social distancing. Preschools and primary schools remained open. Several studies have shown negative impacts of the pandemic on children, particularly high levels of anxiety. The study aim was to explore how Swedish school-aged children aged 6-14 years, experienced the COVID-19 pandemic and their perceived anxiety.\n\nIn total, 774 children aged 6-14 years and their guardians answered an online questionnaire containing 24 questions, along with two instruments measuring anxiety: the Children's Anxiety Questionnaire and the Numerical Rating Scale. A convergent parallel mixed-methods design was used for analysing the quantitative and qualitative data. Each data source was first analysed separately, followed by a merged interpretative analysis.\n\nThe results showed generally low levels of anxiety, with no significant sex differences. Children who refrained from normal social activities or group activities (n=377) had significantly higher levels of anxiety. Most of the children were able to appreciate the bright side of life, despite the social distancing and refraining from activities, which prevented them from meeting and hugging their loved ones.\n\nThese Swedish children generally experienced low levels of anxiety, except those who refrained from social activities. Life was nonetheless mostly experienced as normal, largely because schools remained open. Keeping life as normal as possible could be one important factor in preventing higher anxiety and depression levels in children during a pandemic.", "doi": "10.1177/14034948221108250", "pmid": "35799462", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9361420"}], "notes": [], "created": "2022-08-17T10:45:35.107Z", "modified": "2023-01-13T13:37:17.582Z"}, {"entity": "publication", "iuid": "61c32411a7c54756878158ee59df6fed", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61c32411a7c54756878158ee59df6fed.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61c32411a7c54756878158ee59df6fed"}}, "title": "Validation of a noninvasive aMMP-8 point-of-care diagnostic methodology in COVID-19 patients with periodontal disease.", "authors": [{"family": "Gupta", "given": "Shipra", "initials": "S", "orcid": "0000-0003-2097-2459", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa6dd4cea3824827b3ead550b8267b2a.json"}}, {"family": "Mohindra", "given": "Ritin", "initials": "R"}, {"family": "Singla", "given": "Mohita", "initials": "M"}, {"family": "Khera", "given": "Sagar", "initials": "S"}, {"family": "Kumar", "given": "Amit", "initials": "A"}, {"family": "Rathnayake", "given": "Nilminie", "initials": "N"}, {"family": "Sorsa", "given": "Timo", "initials": "T"}, {"family": "Pf\u00fctzner", "given": "Andreas", "initials": "A"}, {"family": "R\u00e4is\u00e4nen", "given": "Ismo T", "initials": "IT", "orcid": "0000-0001-5821-5299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5688183e182e4194888dc98301077bab.json"}}, {"family": "Soni", "given": "Roop K", "initials": "RK"}, {"family": "Kanta", "given": "Poonam", "initials": "P"}, {"family": "Jain", "given": "Akanksha", "initials": "A"}, {"family": "Gauba", "given": "Krishan", "initials": "K"}, {"family": "Goyal", "given": "Kapil", "initials": "K"}, {"family": "Singh", "given": "Mini P", "initials": "MP"}, {"family": "Ghosh", "given": "Arnab", "initials": "A"}, {"family": "Kajal", "given": "Kamal", "initials": "K"}, {"family": "Mahajan", "given": "Varun", "initials": "V"}, {"family": "Suri", "given": "Vikas", "initials": "V"}, {"family": "Bhalla", "given": "Ashish", "initials": "A"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Clin Exp Dent Res", "issn": "2057-4347", "volume": "8", "issue": "4", "pages": "988-1001", "issn-l": null}, "abstract": "The aim of this study was to validate an active matrix metalloproteinase (MMP-8) point-of-care diagnostic tool in COVID-19 patients with periodontal disease.\n\nSeventy-two COVID-19-positive and 30 COVID-19-negative subjects were enrolled in the study. Demographic data were recorded, periodontal examination carried out, and chairside tests run for evaluating the expression of active MMP-8 (aMMP-8) in the site with maximum periodontal breakdown via gingival crevicular fluid sampling as well as via a mouth rinse-based kit for general disease activity. In COVID-19-positive patients, the kits were run again once the patients turned COVID-19 negative.\n\nThe overall (n = 102) sensitivity/specificity of the mouthrinse-based kits to detect periodontal disease was 79.41%/36.76% and that of site-specific kits was 64.71%/55.88% while adjusting for age, gender, and smoking status increased the sensitivity and specificity (82.35%/76.47% and 73.53%/88.24, respectively). Receiver operating characteristic (ROC) analysis for the adjusted model revealed very good area under the ROC curve 0.746-0.869 (p < .001) and 0.740-0.872 (p < .001) (the aMMP-8 mouth rinse and site-specific kits, respectively). No statistically significant difference was observed in the distribution of results of aMMP-8 mouth rinse test (p = .302) and aMMP-8 site-specific test (p = .189) once the subjects recovered from COVID-19.\n\nThe findings of the present study support the aMMP-8 point-of-care testing (PoCT) kits as screening tools for periodontitis in COVID-19 patients. The overall screening accuracy can be further increased by utilizing adjunctively risk factors of periodontitis. The reported noninvasive, user-friendly, and objective PoCT diagnostic methodology may provide a way of stratifying risk groups, deciding upon referrals, and in the institution of diligent oral hygiene regimens.", "doi": "10.1002/cre2.589", "pmid": "35818743", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9350191"}], "notes": [], "created": "2022-08-17T10:38:13.639Z", "modified": "2022-08-17T10:38:13.684Z"}, {"entity": "publication", "iuid": "d1eb92db423247949c9d1e0866bfded6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1eb92db423247949c9d1e0866bfded6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1eb92db423247949c9d1e0866bfded6"}}, "title": "SARS-COV-2 a trigger of myelin oligodendrocyte glycoprotein-associated disorder.", "authors": [{"family": "Johnsson", "given": "Magnus", "initials": "M", "orcid": "0000-0001-7151-201X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6bef027f84b48efa6d645d3ce116414.json"}}, {"family": "Asztely", "given": "Fredrik", "initials": "F"}, {"family": "Hejnebo", "given": "Susanne", "initials": "S"}, {"family": "Axelsson", "given": "Markus", "initials": "M"}, {"family": "Malmestr\u00f6m", "given": "Clas", "initials": "C", "orcid": "0000-0003-2477-0088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1de3045467364de388c62f23a8a4e171.json"}}, {"family": "Olausson", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Lycke", "given": "Jan", "initials": "J", "orcid": "0000-0002-7891-8466", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/95ab980b7e15438f94f49826d1c4487a.json"}}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Ann Clin Transl Neurol", "issn": "2328-9503", "volume": "9", "issue": "8", "pages": "1296-1301", "issn-l": "2328-9503"}, "abstract": "SARS-COV-2 frequently cause neurological disorders and is sometimes associated with onset of autoimmune diseases affecting the nervous system. Over recent years, a rare but distinct diagnosis designated myelin oligodendrocyte glycoprotein-associated disorder (MOGAD) has been recognized in patients with attacks of optic neuritis, myelitis, or encephalomyelitis and increased levels of anti-MOG antibodies. The cause of MOGAD is unknown. However, there have been reports of single cases of MOGAD in patients with Covid-19 infection. We report a series of SARS-CoV-2 positive patients that developed MOGAD, but a homology search did not support a cross-reactive immune response to SARS-CoV-2 spike-protein and MOG.", "doi": "10.1002/acn3.51609", "pmid": "35713508", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9349599"}], "notes": [], "created": "2022-06-20T18:05:43.774Z", "modified": "2022-08-17T12:46:46.703Z"}, {"entity": "publication", "iuid": "2805ba660c7c40539470a6f03e67b32d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2805ba660c7c40539470a6f03e67b32d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2805ba660c7c40539470a6f03e67b32d"}}, "title": "Risk factors for multisystem inflammatory syndrome in children - A population-based cohort study of over 2 million children.", "authors": [{"family": "Rhedin", "given": "Samuel", "initials": "S"}, {"family": "Lundholm", "given": "Cecilia", "initials": "C"}, {"family": "Horne", "given": "AnnaCarin", "initials": "A"}, {"family": "Smew", "given": "Awad I", "initials": "AI"}, {"family": "Osvald", "given": "Emma Caffrey", "initials": "EC"}, {"family": "Haddadi", "given": "Araz", "initials": "A"}, {"family": "Alfv\u00e9n", "given": "Tobias", "initials": "T"}, {"family": "Kahn", "given": "Robin", "initials": "R"}, {"family": "Kr\u00f3l", "given": "Petra", "initials": "P"}, {"family": "Swedish Pediatric MIS-C Consortium", "given": "", "initials": ""}, {"family": "Brew", "given": "Bronwyn Haasdyk", "initials": "BH"}, {"family": "Almqvist", "given": "Catarina", "initials": "C"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "19", "pages": "100443", "issn-l": null}, "abstract": "Although severe acute COVID-19 is rare in children, SARS-CoV-2 infection can trigger the novel post-infectious condition multisystem inflammatory syndrome in children (MIS-C). Increased knowledge on risk factors for MIS-C could improve our understanding of the pathogenesis of the condition and better guide targeted public health interventions. The aim of the study was to assess risk factors for MIS-C with the aim to identify vulnerable children.\n\nA register-based cohort study including all children and adolescents <19 years born in Sweden between March 1, 2001- December 31, 2020 was performed. Data on sociodemographic risk factors and comorbidities (sex, age, parental region of birth, parental education, asthma, autoimmune disease, chromosomal anomalies, chronic heart disease, chronic lung disease, obesity, life-limiting condition) were retrieved from national health and population registers. The outcome was MIS-C diagnosis according to the Swedish Pediatric Rheumatology Quality Register during March 1, 2020 - December 8, 2021.Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox regression analysis. Incidence rates per 100 000 person-years were calculated assuming a Poisson distribution.\n\nAmong 2 117 443 children included in the study, 253 children developed MIS-C, corresponding to an incidence rate of 6\u00b78 (95% CI: 6\u00b70-7\u00b76) per 100 000 person-years. Male sex (HR 1\u00b765, 95% CI: 1\u00b728-2\u00b714), age 5-11 years (adjusted HR 1\u00b744, 95% CI: 1\u00b706-1\u00b795 using children 0-4 years as reference), foreign-born parents (HR 2\u00b753, 95% CI: 1\u00b793-3\u00b734), asthma (aHR 1\u00b749, 95% CI: 1\u00b700-2\u00b720), obesity (aHR 2\u00b715, 95% CI: 1\u00b709-4\u00b725) and life-limiting conditions (aHR 3\u00b710, 95% CI: 1\u00b780-5\u00b733) were associated with MIS-C. Children 16-18 years had a reduced risk for MIS-C (aHR 0\u00b745, 95% CI: 0\u00b724-0\u00b785).\n\nWe report increased risks for MIS-C in children with male sex, age 5-11 years, foreign-born parents, asthma, obesity, and life-limiting condition. Knowing these risk populations might facilitate identification of children with MIS-C and potentially guide targeted public health interventions. Nevertheless, the absolute risks for MIS-C were very low.\n\nFinancial support was provided from the Swedish Research Council (grant no 2018-02640), the Swedish Heart-Lung Foundation (grant no 20210416), the Asthma and Allergy Association, Ake Wiberg foundation, the Samariten Foundation, the Society of Child Care, and Region Stockholm.", "doi": "10.1016/j.lanepe.2022.100443", "pmid": "35945929", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(22)00137-5"}, {"db": "pmc", "key": "PMC9353212"}], "notes": [], "created": "2022-08-11T11:49:13.500Z", "modified": "2022-08-11T11:49:13.513Z"}, {"entity": "publication", "iuid": "00a60a53400d4140af4f0c1811e60055", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/00a60a53400d4140af4f0c1811e60055.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/00a60a53400d4140af4f0c1811e60055"}}, "title": "Public health, surveillance policies and actions to prevent community spread of COVID-19 in Denmark, Serbia and Sweden.", "authors": [{"family": "Andersen", "given": "Pernille Tanggaard", "initials": "PT", "orcid": "0000-0001-7334-761X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7af3f08a7c14f0f957525c519bd228f.json"}}, {"family": "Loncarevic", "given": "Natasa", "initials": "N"}, {"family": "Damgaard", "given": "Maria Busk", "initials": "MB"}, {"family": "Jacobsen", "given": "Mette Winge", "initials": "MW"}, {"family": "Bassioni-Stamenic", "given": "Farida", "initials": "F"}, {"family": "Eklund Karlsson", "given": "Leena", "initials": "L", "orcid": "0000-0003-2052-0989", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8ef669769e44be2abff29ee81474c49.json"}}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "711-729", "volume": "50", "issue": "6", "issn-l": "1403-4948"}, "abstract": "Aim: This study investigates the non-medical public health and surveillance policies and actions for tackling the community spread of COVID-19 pandemic in Denmark, Serbia and Sweden during the first five months of the pandemic in 2020. Method: The study is inspired by a process-tracing design for case study with a focus on the non-medical measures and surveillance strategies implemented by the three countries. The comprehensive collection and study of national documents formed the basis of the document analysis. Results: The Danish strategy was to prolong the transmission period, preventing high numbers of infected cases from impacting their healthcare capacity. The government's strategy was characterized by strict governance elements, health guidelines and behavioural recommendations. In Serbia, the main strategy was to prevent the spread and control of the infectious disease by shifting all human and material resources towards the function of controlling the spread. Serbia applied the strictest measures in the fight against coronavirus in relation to other countries in the region and in Europe. The Swedish strategy focused more on recommendations than requirements to motivate the public to modify their behaviours voluntarily. Sweden's loose pandemic strategy implementation focused on voluntary and stepwise action rather than legislation and compulsory measures. Conclusions:The public health policies and actions implemented to prevent community spread of COVID-19 in Denmark, Serbia and Sweden varied during the first five months of the pandemic. The differences in their response were due to delays in implementation, inconsistencies in perspectives towards the outbreak and the capacity of each country in terms of their pandemic preparedness and response.", "doi": "10.1177/14034948211056215", "pmid": "34844483", "labels": {"Type: Review": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T18:10:53.356Z", "modified": "2023-01-13T14:46:19.134Z"}, {"entity": "publication", "iuid": "43eb008807304184af3e179e29e7898e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/43eb008807304184af3e179e29e7898e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/43eb008807304184af3e179e29e7898e"}}, "title": "Outcome of infection with omicron SARS-CoV-2 variant in patients with hematological malignancies: An EPICOVIDEHA survey report.", "authors": [{"family": "Blennow", "given": "Ola", "initials": "O", "orcid": "0000-0002-7167-7882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2318c3973e66443aa14fceca0908d127.json"}}, {"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J", "orcid": "0000-0002-6766-8297", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dea501020d2042ad83d1b024987792f4.json"}}, {"family": "Nowak", "given": "Piotr", "initials": "P", "orcid": "0000-0003-2747-0734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1d81fdccf9e424fa99ea5227b031843.json"}}, {"family": "Itri", "given": "Federico", "initials": "F", "orcid": "0000-0002-3532-5281", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98feda63fd134739ab222629acdc3e46.json"}}, {"family": "Van Doesum", "given": "Jaap", "initials": "J", "orcid": "0000-0003-0214-3219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49152311cb004139904554d1c096c05c.json"}}, {"family": "L\u00f3pez-Garc\u00eda", "given": "Alberto", "initials": "A", "orcid": "0000-0002-5354-5261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c785356a67e4cbb9835fe9ce04a6153.json"}}, {"family": "Farina", "given": "Francesca", "initials": "F", "orcid": "0000-0002-5124-6970", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06ead8985bd241ee814a94a6186bb898.json"}}, {"family": "Jaksic", "given": "Ozren", "initials": "O", "orcid": "0000-0003-4026-285X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/359a2798d30a4a5aa03f587bfb87322f.json"}}, {"family": "Pincz\u00e9s", "given": "L\u00e1szl\u00f3 Imre", "initials": "LI", "orcid": "0000-0003-0453-1709", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed1924c856a44492a74f02654b53ca61.json"}}, {"family": "Bilgin", "given": "Yavuz M", "initials": "YM", "orcid": "0000-0002-3783-3407", "researcher": {"href": 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"Rebeca", "initials": "R", "orcid": "0000-0003-2838-1776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d185c2be2bd4d8b9929a1812ae9d327.json"}}, {"family": "Hoenigl", "given": "Martin", "initials": "M", "orcid": "0000-0002-1653-2824", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f06a81d02454972bb9b64fea7c14dd4.json"}}, {"family": "Dragonetti", "given": "Giulia", "initials": "G", "orcid": "0000-0003-1775-6333", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81694822ac4d4074bfabe757d03f5f9e.json"}}, {"family": "Chai", "given": "Louis Yi Ann", "initials": "LYA"}, {"family": "Kho", "given": "Chi Shan", "initials": "CS"}, {"family": "Bonanni", "given": "Matteo", "initials": "M"}, {"family": "Li\u00e9vin", "given": "Rapha\u00ebl", "initials": "R", "orcid": "0000-0002-5097-591X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d190434cf5f428f9714a761a1b67889.json"}}, {"family": "Marchesi", "given": "Francesco", "initials": "F", "orcid": "0000-0001-6353-2272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e09d8d1e4eb498781444b8d095687a0.json"}}, {"family": "Cornely", "given": "Oliver A", "initials": "OA", "orcid": "0000-0001-9599-3137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3c62d8346924e69b6c99e4007c3831c.json"}}, {"family": "Pagano", "given": "Livio", "initials": "L", "orcid": "0000-0001-8287-928X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbf92a9779614910aeafcc6c21d880e2.json"}}], "type": "letter", "published": "2022-08-00", "journal": {"title": "Am J Hematol", "issn": "0361-8609", "issn-l": null, "volume": "97", "issue": "8", "pages": "E312-E317"}, "abstract": null, "doi": "10.1002/ajh.26626", "pmid": "35702878", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9349555"}], "notes": [], "created": "2022-06-20T18:12:52.201Z", "modified": "2022-08-17T13:00:29.008Z"}, {"entity": "publication", "iuid": "419c229086fc4e749e9c98b961bac8fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/419c229086fc4e749e9c98b961bac8fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/419c229086fc4e749e9c98b961bac8fc"}}, "title": "Monoclonal antibodies binding data for SARS-CoV-2 proteins.", "authors": [{"family": "Mishra", "given": "Nawneet", "initials": "N"}, {"family": "Teyra", "given": "Joan", "initials": "J"}, {"family": "Boytz", "given": "RuthMabel", "initials": "R"}, {"family": "Miersch", "given": "Shane", "initials": "S"}, {"family": "Merritt", "given": "Trudy N", "initials": "TN"}, {"family": "Cardarelli", "given": "Lia", "initials": "L"}, {"family": "Gorelik", "given": "Maryna", "initials": "M"}, {"family": "Mihalic", "given": "Filip", "initials": "F"}, {"family": "Jemth", "given": "Per", "initials": "P"}, {"family": "Davey", "given": "Robert A", "initials": "RA"}, {"family": "Sidhu", "given": "Sachdev S", "initials": "SS"}, {"family": "Leung", "given": "Daisy W", "initials": "DW"}, {"family": "Amarasinghe", "given": "Gaya K", "initials": "GK"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Data Brief", "issn": "2352-3409", "volume": "43", "pages": "108415", "issn-l": null}, "abstract": "SARS-CoV-2 pandemic opens up the curiosity of understanding the coronavirus. This demand for the development of the regent, which can be used for academic and therapeutic applications. The present data provide the biochemical characterization of synthetically developed monoclonal antibodies for the SARS-CoV-2 proteins. The antibodies from phage-displayed antibody libraries were selected with the SARS-CoV-2 proteins immobilized in microwell plates. The clones which bind to the antigen in Fab-phage ELISA were selected, and a two-point competitive phage ELISA was performed. Antibodies binding kinetic of IgGs for SARS-CoV2 proteins further carried with B.L.I. Systematic analysis of binding with different control proteins and purified SARS-CoV-2 ensured the robustness of the antibodies.", "doi": "10.1016/j.dib.2022.108415", "pmid": "35789908", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9232259"}, {"db": "pii", "key": "S2352-3409(22)00612-6"}], "notes": [], "created": "2022-08-17T13:08:36.040Z", "modified": "2023-06-19T15:05:48.083Z"}, {"entity": "publication", "iuid": "b8e48b55409345ff8cabbd0a928ab919", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8e48b55409345ff8cabbd0a928ab919.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8e48b55409345ff8cabbd0a928ab919"}}, "title": "Milder disease trajectory among COVID-19 patients hospitalised with the SARS-CoV-2 Omicron variant compared with the Delta variant in Norway.", "authors": [{"family": "St\u00e5lcrantz", "given": "Jeanette", "initials": "J", "orcid": "0000-0001-8086-4244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e6220d843754651b919cae3e687d3d5.json"}}, {"family": "Kristoffersen", "given": "Anja Br\u00e5then", "initials": "AB"}, {"family": "B\u00f8\u00e5s", "given": "H\u00e5kon", "initials": "H", "orcid": "0000-0002-5917-1563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9cc00f104cd64e53ab58eebd46368861.json"}}, {"family": "Veneti", "given": "Lamprini", "initials": "L"}, {"family": "Sepp\u00e4l\u00e4", "given": "Elina", "initials": "E"}, {"family": "Aasand", "given": "Nina", "initials": "N"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "Kv\u00e5le", "given": "Reidar", "initials": "R"}, {"family": "Bragstad", "given": "Karoline", "initials": "K"}, {"family": "Buanes", "given": "Eirik Alnes", "initials": "EA"}, {"family": "Whittaker", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "volume": "50", "issue": "6", "pages": "676-682", "issn-l": "1403-4948"}, "abstract": "Using individual-level national registry data, we conducted a cohort study to estimate differences in the length of hospital stay, and risk of admission to an intensive care unit and in-hospital death among patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant, compared with patients infected with Delta variant in Norway. We included 409 (38%) patients infected with Omicron and 666 (62%) infected with Delta who were hospitalised with coronavirus disease 2019 (COVID-19) as the main cause of hospitalisation between 6 December 2021 and 6 February 2022. Omicron patients had a 48% lower risk of intensive care admission (adjusted hazard ratios (aHR): 0.52, 95% confidence interval (CI): 0.34-0.80) and a 56% lower risk of in-hospital death (aHR: 0.44, 95%CI: 0.24-0.79) compared with Delta patients. Omicron patients had a shorter length of stay (with or without ICU stay) compared with Delta patients in the age groups from 18 to 79 years and those who had at least completed their primary vaccination. This supports growing evidence of reduced disease severity among hospitalised Omicron patients compared with Delta patients.", "doi": "10.1177/14034948221108548", "pmid": "35799474", "labels": {"Category: Omicron VoC": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-17T10:45:15.917Z", "modified": "2022-08-17T10:45:16.004Z"}, {"entity": "publication", "iuid": "d2cf9578d52c495ca762c0a8332d614c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d2cf9578d52c495ca762c0a8332d614c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d2cf9578d52c495ca762c0a8332d614c"}}, "title": "Lessons from the IMPAACT of coronavirus disease 2019 public health restrictions on food allergy-associated anxiety.", "authors": [{"family": "Golding", "given": "Michael A", "initials": "MA"}, {"family": "Protudjer", "given": "Jennifer L P", "initials": "JLP"}], "type": "editorial", "published": "2022-08-00", "journal": {"title": "Ann Allergy Asthma Immunol", "issn": "1534-4436", "volume": "129", "issue": "2", "pages": "134-135", "issn-l": null}, "abstract": null, "doi": "10.1016/j.anai.2022.05.018", "pmid": "35878957", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1081-1206(22)00450-1"}], "notes": [], "created": "2022-08-12T08:39:02.556Z", "modified": "2022-08-12T08:39:02.586Z"}, {"entity": "publication", "iuid": "1c6630c4d7dc433d982ba605747c9041", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1c6630c4d7dc433d982ba605747c9041.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1c6630c4d7dc433d982ba605747c9041"}}, "title": "Income differences in COVID-19 incidence and severity in Finland among people with foreign and native background: A population-based cohort study of individuals nested within households.", "authors": [{"family": "Saarinen", "given": "Sanni", "initials": "S", "orcid": "0000-0002-4866-002X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/311a9e98129c432782f7e893757c60a1.json"}}, {"family": "Moustgaard", "given": "Heta", "initials": "H"}, {"family": "Remes", "given": "Hanna", "initials": "H", "orcid": "0000-0002-9291-703X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cbdeb824ba154b5595275b2275e32568.json"}}, {"family": "Sallinen", "given": "Riikka", "initials": "R"}, {"family": "Martikainen", "given": "Pekka", "initials": "P", "orcid": "0000-0001-9374-1438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc740067d77b4773826c66c9eddc6827.json"}}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "PLoS Med", "issn": "1549-1676", "volume": "19", "issue": "8", "pages": "e1004038", "issn-l": "1549-1277"}, "abstract": "Although intrahousehold transmission is a key source of Coronavirus Disease 2019 (COVID-19) infections, studies to date have not analysed socioeconomic risk factors on the household level or household clustering of severe COVID-19. We quantify household income differences and household clustering of COVID-19 incidence and severity.\n\nWe used register-based cohort data with individual-level linkage across various administrative registers for the total Finnish population living in working-age private households (N = 4,315,342). Incident COVID-19 cases (N = 38,467) were identified from the National Infectious Diseases Register from 1 July 2020 to 22 February 2021. Severe cases (N = 625) were defined as having at least 3 consecutive days of inpatient care with a COVID-19 diagnosis and identified from the Care Register for Health Care between 1 July 2020 and 31 December 2020. We used 2-level logistic regression with individuals nested within households to estimate COVID-19 incidence and case severity among those infected. Adjusted for age, sex, and regional characteristics, the incidence of COVID-19 was higher (odds ratio [OR] 1.67, 95% CI 1.58 to 1.77, p < 0.001, 28.4% of infections) among individuals in the lowest household income quintile than among those in the highest quintile (18.9%). The difference attenuated (OR 1.23, 1.16 to 1.30, p < 0.001) when controlling for foreign background but not when controlling for other household-level risk factors. In fact, we found a clear income gradient in incidence only among people with foreign background but none among those with native background. The odds of severe illness among those infected were also higher in the lowest income quintile (OR 1.97, 1.52 to 2.56, p < 0.001, 28.0% versus 21.6% in the highest quintile), but this difference was fully attenuated (OR 1.08, 0.77 to 1.52, p = 0.64) when controlling for other individual-level risk factors-comorbidities, occupational status, and foreign background. Both incidence and severity were strongly clustered within households: Around 77% of the variation in incidence and 20% in severity were attributable to differences between households. The main limitation of our study was that the test uptake for COVID-19 may have differed between population subgroups.\n\nLow household income appears to be a strong risk factor for both COVID-19 incidence and case severity, but the income differences are largely driven by having foreign background. The strong household clustering of incidence and severity highlights the importance of household context in the prevention and mitigation of COVID-19 outcomes.", "doi": "10.1371/journal.pmed.1004038", "pmid": "35947575", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PMEDICINE-D-21-04207"}], "notes": [], "created": "2022-08-11T11:47:22.362Z", "modified": "2022-08-12T08:30:09.536Z"}, {"entity": "publication", "iuid": "eb25df38bf974d95a90185675f983989", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb25df38bf974d95a90185675f983989.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb25df38bf974d95a90185675f983989"}}, "title": "Health care utilization and outcomes in older adults after Traumatic Brain Injury: A CENTER-TBI study.", "authors": [{"family": "van der Vlegel", "given": "Marjolein", "initials": "M"}, {"family": "Mikoli\u0107", "given": "Ana", "initials": "A"}, {"family": "Lee Hee", "given": "Quentin", "initials": "Q"}, {"family": "Kaplan", "given": "Z L Rana", "initials": "ZLR"}, {"family": "Retel Helmrich", "given": "Isabel R A", "initials": "IRA"}, {"family": "van Veen", "given": "Ernest", "initials": "E"}, {"family": "Andelic", "given": "Nada", "initials": "N"}, {"family": "Steinbuechel", "given": "Nicole V", "initials": "NV"}, {"family": "Plass", "given": "Anne Marie", "initials": "AM"}, {"family": "Zeldovich", "given": "Marina", "initials": "M"}, {"family": "Wilson", "given": "Lindsay", "initials": "L"}, {"family": "Maas", "given": "Andrew I R", "initials": "AIR"}, {"family": "Haagsma", "given": "Juanita A", "initials": "JA"}, {"family": "Polinder", "given": "Suzanne", "initials": "S"}, {"family": "CENTER-TBI Participants and Investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Injury", "issn": "1879-0267", "volume": "53", "issue": "8", "pages": "2774-2782", "issn-l": null}, "abstract": "The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged \u226565 years, forming a growing public health problem. However, older adults are underrepresented in TBI research. Therefore, we aimed to provide an overview of health-care utilization, and of six-month outcomes after TBI and their determinants in older adults who sustained a TBI.\n\nWe used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. In-hospital and post-hospital health care utilization and outcomes were described for patients aged \u226565 years. Ordinal and linear regression analyses were performed to identify determinants of the Glasgow Outcome Scale Extended (GOSE), health-related quality of life (HRQoL), and mental health symptoms six-months post-injury.\n\nOf 1254 older patients, 45% were admitted to an ICU with a mean length of stay of 9 days. Nearly 30% of the patients received inpatient rehabilitation. In total, 554/1254 older patients completed the six-month follow-up questionnaires. The mortality rate was 9% after mild and 60% after moderate/severe TBI, and full recovery based on GOSE was reported for 44% of patients after mild and 6% after moderate/severe TBI. Higher age and increased injury severity were primarily associated with functional impairment, while pre-injury systemic disease, psychiatric conditions and lower educational level were associated with functional impairment, lower generic and disease-specific HRQoL and mental health symptoms.\n\nThe rate of impairment and disability following TBI in older adults is substantial, and poorer outcomes across domains are associated with worse preinjury health. Nonetheless, a considerable number of patients fully or partially returns to their preinjury functioning. There should not be pessimism about outcomes in older adults who survive.", "doi": "10.1016/j.injury.2022.05.009", "pmid": "35725508", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0020-1383(22)00329-1"}], "notes": [], "created": "2022-08-17T13:04:27.837Z", "modified": "2022-08-17T13:04:27.864Z"}, {"entity": "publication", "iuid": "4a20c42bea8642c68d665eda819b9577", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4a20c42bea8642c68d665eda819b9577.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4a20c42bea8642c68d665eda819b9577"}}, "title": "Gaming and social media use among adolescents in the midst of the COVID-19 pandemic.", "authors": [{"family": "Nilsson", "given": "Anders", "initials": "A", "orcid": "0000-0002-0982-8483", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aaa310c68f1a475380fe60327e00405f.json"}}, {"family": "Rosendahl", "given": "Ingvar", "initials": "I", "orcid": "0000-0002-1325-913X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bbfd62b47d64bf1909cdc79d6d85054.json"}}, {"family": "Jayaram-Lindstr\u00f6m", "given": "Nitya", "initials": "N"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Nordisk Alkohol Nark", "issn": "1458-6126", "volume": "39", "issue": "4", "pages": "347-361", "issn-l": null}, "abstract": "Background and aims: The COVID-19 pandemic has dramatically changed life circumstances for adolescents worldwide. With schools being closed and regular activities being cancelled, gaming and social media use are activities that might gain in importance. There is a risk that these online behaviours have negative effects on other important activities, such as being physically active, sleeping, and studying, as well as general well-being. The aim of this study was to investigate the effects of the COVID-19 pandemic on gaming and social media use, and its effects on the well-being of adolescents. Methods: A total of 1232 adolescents (82.5% female) participated in an anonymous web survey containing questions on gaming, social media use, and perceived negative consequences of gaming and social media use during the COVID-19 pandemic. The results were analysed with a quasi-Poisson regression model. Results: The results indicated an increase in gaming and social media use, which was associated with negative consequences and perceived well-being. A majority of adolescents reported that they used social media more than they felt comfortable with. There were large differences between boys and girls, with girls being more negatively affected across measures. Discussion: The increase in gaming and social media use during the COVID-19 pandemic might have negative effects on the well-being of adolescents, and on other activities that are important to health. Our interpretation of the findings is that gaming and social media use might partly function as coping mechanisms to deal with stress and/or boredom resulting from COVID-19 restrictions. There is a risk that these coping strategies become maladaptive over time. Conclusions: The restrictions from the COVID-19 pandemic have resulted in an increase in the amount of time adolescents spend gaming and on social media, which might have negative effects on their well-being. This study highlights the urgent need to consider adaptive and healthy coping strategies for adolescents given the pandemic may mean that daily living could continue to be altered in the near future.", "doi": "10.1177/14550725221074997", "pmid": "35999947", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1177_14550725221074997"}, {"db": "pmc", "key": "PMC8819558"}], "notes": [], "created": "2022-08-26T04:44:06.685Z", "modified": "2022-08-26T04:44:06.799Z"}, {"entity": "publication", "iuid": "c43b69e1fdf14da28e0eb4ba5b79d1a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c43b69e1fdf14da28e0eb4ba5b79d1a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c43b69e1fdf14da28e0eb4ba5b79d1a4"}}, "title": "Epigenetic mechanisms regulate sex-specific bias in disease manifestations.", "authors": [{"family": "Chlamydas", "given": "Sarantis", "initials": "S"}, {"family": "Markouli", "given": "Mariam", "initials": "M"}, {"family": "Strepkos", "given": "Dimitrios", "initials": "D"}, {"family": "Piperi", "given": "Christina", "initials": "C", "orcid": "0000-0002-2701-0618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15e4ce9ec9754a6b881eaaa8d1de3c17.json"}}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "J Mol Med (Berl)", "issn": "1432-1440", "volume": "100", "issue": "8", "pages": "1111-1123", "issn-l": null}, "abstract": "Sex presents a vital determinant of a person's physiology, anatomy, and development. Recent clinical studies indicate that sex is also involved in the differential manifestation of various diseases, affecting both clinical outcome as well as response to therapy. Genetic and epigenetic changes are implicated in sex bias and regulate disease onset, including the inactivation of the X chromosome as well as sex chromosome aneuploidy. The differential expression of X-linked genes, along with the presence of sex-specific hormones, exhibits a significant impact on immune system function. Several studies have revealed differences between the two sexes in response to infections, including respiratory diseases and COVID-19 infection, autoimmune disorders, liver fibrosis, neuropsychiatric diseases, and cancer susceptibility, which can be explained by sex-biased immune responses. In the present review, we explore the input of genetic and epigenetic interplay in the sex bias underlying disease manifestation and discuss their effects along with sex hormones on disease development and progression, aiming to reveal potential new therapeutic targets. KEY MESSAGES: Sex is involved in the differential manifestation of various diseases. Epigenetic modifications influence X-linked gene expression, affecting immune response to infections, including COVID-19. Epigenetic mechanisms are responsible for the sex bias observed in several respiratory and autoimmune disorders, liver fibrosis, neuropsychiatric diseases, and cancer.", "doi": "10.1007/s00109-022-02227-x", "pmid": "35764820", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00109-022-02227-x"}, {"db": "pmc", "key": "PMC9244100"}], "notes": [], "created": "2022-08-19T05:34:12.520Z", "modified": "2022-08-19T05:34:22.233Z"}, {"entity": "publication", "iuid": "c3deb4b2a368402997300e196e67df11", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3deb4b2a368402997300e196e67df11.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3deb4b2a368402997300e196e67df11"}}, "title": "Corrigendum. Re: de Sousa, N.R., et al., 2022. Detection and isolation of airborne SARS-CoV-2 in a hospital setting. Indoor air, 32(3), e13023.", "authors": [{"family": "Rufino de Sousa", "given": "Nuno", "initials": "N", "orcid": "0000-0002-0670-9788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1cb037a9e7f44a489dd84d6f5ba513d7.json"}}, {"family": "Steponaviciute", "given": "Laura", "initials": "L"}, {"family": "Margerie", "given": "Lucille", "initials": "L", "orcid": "0000-0001-9537-1231", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e7015e5251242ecb70df112f997182b.json"}}, {"family": "Nissen", "given": "Karolina", "initials": "K"}, {"family": "Kjellin", "given": "Midori", "initials": "M", "orcid": "0000-0002-1377-6014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cbf761ec44641a5a70ee1b8f7964a20.json"}}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Salaneck", "given": "Erik", "initials": "E"}, {"family": "Udekwu", "given": "Klas I", "initials": "KI"}, {"family": "Rothfuchs", "given": "Antonio Gigliotti", "initials": "AG", "orcid": "0000-0001-6001-7240", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00102c49ae2d41828272e850cd551c9f.json"}}], "type": "letter", "published": "2022-08-00", "journal": {"title": "Indoor Air", "issn": "0905-6947", "volume": "32", "issue": "8", "pages": "e13085", "issn-l": null}, "abstract": null, "doi": "10.1111/ina.13085", "pmid": "36040276", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-10-07T12:50:16.510Z", "modified": "2022-10-07T12:51:48.911Z"}, {"entity": "publication", "iuid": "e7c6cac338774bdd8fc521b6eaadba9b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e7c6cac338774bdd8fc521b6eaadba9b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e7c6cac338774bdd8fc521b6eaadba9b"}}, "title": "Changes in mortality trends amongst common diseases during the COVID-19 pandemic in Sweden.", "authors": [{"family": "Axenhus", "given": "Michael", "initials": "M", "orcid": "0000-0002-2476-4465", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c8ec5de3a68400981b1caa3e5260828.json"}}, {"family": "Schedin-Weiss", "given": "Sophia", "initials": "S"}, {"family": "Winblad", "given": "Bengt", "initials": "B"}, {"family": "Wimo", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "748-755", "volume": "50", "issue": "6", "issn-l": "1403-4948"}, "abstract": "It has been found that COVID-19 increases deaths within common diseases in countries that have implemented strict lockdowns. In order to elucidate the proper national response to a pandemic, the mortality rates within COVID-19 and various diseases need to be studied in countries whose pandemic response differ. Sweden represents a country with lax pandemic restrictions, and we aimed to study the effects of COVID-19 on historical mortality rates within common diseases during 2020.\n\nRegression models and moving averages were used to predict expected premature mortality per the ICD-10 during 2020 using historical data sets. Predicted values were then compared to recorded premature mortality to identify changes in mortality trends.\n\nSeasonal increased mortality was found within neurological diseases. Infectious diseases, tumours and cardiac disease mortality rates decreased compared to expected outcome.\n\nChanges in mortality trends were observed for several common diseases during the COVID-19 pandemic. Neurological and cardiac conditions, infections and tumours are examples of diseases that were heavily affected by the pandemic. The indirect effects of COVID-19 on certain patient populations should be considered when determining pandemic impact.", "doi": "10.1177/14034948211064656", "pmid": "34933630", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9361422"}], "notes": [], "created": "2022-01-03T15:31:10.078Z", "modified": "2023-01-13T13:36:55.994Z"}, {"entity": "publication", "iuid": "0a372b79beb64fd8a99d8cb5ca649254", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a372b79beb64fd8a99d8cb5ca649254.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a372b79beb64fd8a99d8cb5ca649254"}}, "title": "COVID-19 vaccine hesitancy in Sweden and Italy: The role of trust in authorities.", "authors": [{"family": "Raffetti", "given": "Elena", "initials": "E", "orcid": "0000-0001-8742-3986", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49139fd67cc4feb9e68942e70eecd92.json"}}, {"family": "Mondino", "given": "Elena", "initials": "E"}, {"family": "Di Baldassarre", "given": "Giuliano", "initials": "G"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "803-809", "volume": "50", "issue": "6", "issn-l": "1403-4948"}, "abstract": "The success of vaccination campaigns against COVID-19 infection is vital for moving from a COVID-19 pandemic to an endemic scenario. We aimed to unravel the influence of the risk perception of epidemics along with individual and contextual factors on adherence to COVID-19 vaccination campaigns in Italy and Sweden.\n\nWe compared the results of two nationwide surveys carried out in August 2021 across four domains of epidemic risk perception: perceived likelihood, perceived impact on the individual and perceived individual and authority knowledge. The roles of individual and contextual determinants were also explored.\n\nThe survey included 2144 participants in Sweden (52.3% women) and 2010 in Italy (52.6% women). In both countries, we found that trust in authorities was one of the main drivers of this process, with two-fold increased odds of being vaccinated. Being highly educated and having a higher relative income were associated with a higher adherence to the vaccination campaign (for relative income OR = 1.44, 95% CI 1.23-1.67 in Sweden and OR = 1.18, 95% CI 1.04-1.34 in Italy; for education OR = 1.90, 95% CI 1.30-2.77 in Sweden and OR = 1.47, 95% CI 1.09-1.97 in Italy), whereas a right and centre-right compared with a left and centre-left political orientation was negatively related to vaccination adherence (OR = 0.41, 95% CI 0.25-0.67 in Sweden and OR = 0.47, 95% CI 0.33-0.68 in Italy).\n\nIncreasing trust in authorities, along with an equal global distribution of vaccine doses, can contribute to accelerating vaccination campaigns around the world and, in turn, to move towards an endemic scenario.", "doi": "10.1177/14034948221099410", "pmid": "35656576", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9361415"}], "notes": [], "created": "2022-06-21T17:19:26.872Z", "modified": "2023-01-13T13:26:46.332Z"}, {"entity": "publication", "iuid": "2d8688815a6f4c68bbb3feddac31eff3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d8688815a6f4c68bbb3feddac31eff3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d8688815a6f4c68bbb3feddac31eff3"}}, "title": "COVID vaccination in older adults.", "authors": [{"family": "H\u00e4gg", "given": "Sara", "initials": "S", "orcid": "0000-0002-2452-1500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f65e8028f3a0410099f7dfdbfa79ca42.json"}}, {"family": "Religa", "given": "Dorota", "initials": "D"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Nat Microbiol", "issn": "2058-5276", "volume": "7", "issue": "8", "pages": "1106-1107", "issn-l": null}, "abstract": null, "doi": "10.1038/s41564-022-01166-0", "pmid": "35836001", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41564-022-01166-0"}], "notes": [], "created": "2022-08-12T09:00:47.401Z", "modified": "2022-08-12T09:00:47.457Z"}, {"entity": "publication", "iuid": "9708437ef73e44eda9a26129ec65469d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9708437ef73e44eda9a26129ec65469d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9708437ef73e44eda9a26129ec65469d"}}, "title": "Autoantibodies in COVID-19 correlate with antiviral humoral responses and distinct immune signatures.", "authors": [{"family": "Taeschler", "given": "Patrick", "initials": "P", "orcid": "0000-0003-0522-7629", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b070a1c2cd840849b9e8ce333068867.json"}}, {"family": "Cervia", "given": "Carlo", "initials": "C", "orcid": "0000-0001-7120-8739", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d0c8b0ac68984748ae12d25bf50fdb5d.json"}}, {"family": "Zurbuchen", "given": "Yves", "initials": "Y", "orcid": "0000-0001-5387-9950", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33558ac87673432f8fa00ecad5b9ff6d.json"}}, {"family": "Hasler", "given": "Sara", "initials": "S", "orcid": "0000-0001-7357-9090", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c600e18dbb448dd91b895bb1c380e0f.json"}}, {"family": "Pou", "given": "Christian", "initials": "C", "orcid": "0000-0003-3932-788X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c43110c557a448a58782ba750b5be26e.json"}}, {"family": "Tan", "given": "Ziyang", "initials": "Z", "orcid": "0000-0002-7205-4978", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c593f081713402cac6296f48bffad51.json"}}, {"family": "Adamo", "given": "Sarah", "initials": "S", "orcid": "0000-0002-6161-3156", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01e7ff62bef7421fac217fab2707ed80.json"}}, {"family": "Raeber", "given": "Miro E", "initials": "ME", "orcid": "0000-0003-2609-0246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a14abc410a94f70987ac309368db2c7.json"}}, {"family": "B\u00e4chli", "given": "Esther", "initials": "E", "orcid": "0000-0003-4887-7576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e861fa430c4243e484b8ba62da346f4b.json"}}, {"family": "Rudiger", "given": "Alain", "initials": "A", "orcid": "0000-0001-7943-7624", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d62bfa03c7a41c9905ea62b34b65ee4.json"}}, {"family": "St\u00fcssi-Helbling", "given": "Melina", "initials": "M", "orcid": "0000-0002-7896-6644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0551149ea92e46d8892abc22c8767683.json"}}, {"family": "Huber", "given": "Lars C", "initials": "LC", "orcid": "0000-0001-5378-4716", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bdd38ab4a3ef45cfacdbfb756d794b9f.json"}}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}, {"family": "Nilsson", "given": "Jakob", "initials": "J", "orcid": "0000-0001-5091-8133", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9289345dc02f4457934c6d2771d5fec4.json"}}, {"family": "Probst-M\u00fcller", "given": "Elsbeth", "initials": "E", "orcid": "0000-0002-9046-4196", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d21e67609d84d13a973f89620b68247.json"}}, {"family": "Boyman", "given": "Onur", "initials": "O", "orcid": "0000-0001-8279-5545", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fd89e300ecc4a2b8d4e31f4d85eef8f.json"}}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": "77", "issue": "8", "pages": "2415-2430", "issn-l": "0105-4538"}, "abstract": "Several autoimmune features occur during coronavirus disease 2019 (COVID-19), with possible implications for disease course, immunity, and autoimmune pathology. In this study, we longitudinally screened for clinically relevant systemic autoantibodies to assess their prevalence, temporal trajectory, and association with immunity, comorbidities, and severity of COVID-19.\n\nWe performed highly sensitive indirect immunofluorescence assays to detect antinuclear antibodies (ANA) and antineutrophil cytoplasmic antibodies (ANCA), along with serum proteomics and virome-wide serological profiling in a multicentric cohort of 175 COVID-19 patients followed up to 1 year after infection, eleven vaccinated individuals, and 41 unexposed controls.\n\nCompared with healthy controls, similar prevalence and patterns of ANA were present in patients during acute COVID-19 and recovery. However, the paired analysis revealed a subgroup of patients with transient presence of certain ANA patterns during acute COVID-19. Furthermore, patients with severe COVID-19 exhibited a high prevalence of ANCA during acute disease. These autoantibodies were quantitatively associated with higher SARS-CoV-2-specific antibody titers in COVID-19 patients and in vaccinated individuals, thus linking autoantibody production to increased antigen-specific humoral responses. Notably, the qualitative breadth of antibodies cross-reactive with other coronaviruses was comparable in ANA-positive and ANA-negative individuals during acute COVID-19. In autoantibody-positive patients, multiparametric characterization demonstrated an inflammatory signature during acute COVID-19 and alterations of the B-cell compartment after recovery.\n\nHighly sensitive indirect immunofluorescence assays revealed transient autoantibody production during acute SARS-CoV-2 infection, while the presence of autoantibodies in COVID-19 patients correlated with increased antiviral humoral immune responses and inflammatory immune signatures.", "doi": "10.1111/all.15302", "pmid": "35364615", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9111424"}], "notes": [], "created": "2022-04-04T06:25:29.101Z", "modified": "2022-08-15T13:03:48.444Z"}, {"entity": "publication", "iuid": "eb05c45ac6734422a5c7c047326fc9a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb05c45ac6734422a5c7c047326fc9a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb05c45ac6734422a5c7c047326fc9a0"}}, "title": "A Cohort Study on Influenza Vaccine and All-Cause Mortality in Older Adults: Methodological Concerns and Public Health Implications.", "authors": [{"family": "Lapi", "given": "Francesco", "initials": "F", "orcid": "0000-0002-4342-9128", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06d5cef5638245d598c8c5ae1a514c33.json"}}, {"family": "Marconi", "given": "Ettore", "initials": "E"}, {"family": "Gualano", "given": "Maria Rosaria", "initials": "MR"}, {"family": "Vetrano", "given": "Davide Liborio", "initials": "DL"}, {"family": "Grattagliano", "given": "Ignazio", "initials": "I"}, {"family": "Rossi", "given": "Alessandro", "initials": "A"}, {"family": "Cricelli", "given": "Claudio", "initials": "C"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Drugs Aging", "issn": "1179-1969", "volume": "39", "issue": "8", "pages": "645-656", "issn-l": null}, "abstract": "In 2020, the restrictions adopted to control the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic led to an unprecedented reduction in influenza-related burden. As such, the reduced chance to characterize the circulating virus strains might have increased the risk of vaccine mismatch for the forthcoming winter seasons. The role of an effective influenza vaccination campaign might therefore assume even more value, especially for frail and multimorbid older individuals. Methodological concerns on confounding by indication are always debated in vaccine effectiveness studies and it might be instrumental to give a pragmatic message on an individual's responsibility to receive the influenza vaccine. We therefore investigated the role of specific confounders to explain the association between influenza vaccine and mortality among older adults.\n\nUsing a primary care database, we formed a cohort of patients aged 65 years or older who were actively registered with their general practitioner (GP) at the beginning of each of nine influenza seasons through to the 2018/2019 season. The study index date was the related seasons' starting date. Exposure to the influenza vaccine was operationally defined in the 2 months preceding the index date up to 2 weeks before the exit date. Cox regression models were estimated to calculate hazard ratios (HRs) and their 95% confidence intervals (CI) of death between vaccinated and unvaccinated patients in a time-dependent fashion. The potential confounders sequentially entered the model based on their increasing effect size observed in univariate analyses.\n\nOver the 10 years under study, the influenza vaccine showed a significant protective effect in terms of mortality, reaching 13% reduction (HR 0.87, 95% CI 0.80-0.95) in the 2018/2019 influenza season. When we estimated the multivariate model by sequentially adding the potential confounders, there was an inversion of HR (below the unit) that was significantly explained by the covariates coding for a prior history of lower respiratory tract infections and the presence of the pneumococcal vaccine.\n\nIn the current pandemic scenario, we cannot divert attention to proper use of face masks, social distancing, and hand hygiene, which are important measures to prevent influenza and other respiratory viral infections. Nonetheless, their effectiveness might be negligible without acceptable coverage for influenza vaccine, especially in older patients with a history of lower respiratory tract infections, which appears to be the main source of confounding by indication.", "doi": "10.1007/s40266-022-00958-7", "pmid": "35867212", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9305032"}, {"db": "pii", "key": "10.1007/s40266-022-00958-7"}], "notes": [], "created": "2022-08-12T08:41:43.205Z", "modified": "2023-06-19T15:30:14.102Z"}, {"entity": "publication", "iuid": "a5692e6b107c42baa428115a1abe000a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a5692e6b107c42baa428115a1abe000a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a5692e6b107c42baa428115a1abe000a"}}, "title": "Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework.", "authors": [{"family": "Clerbaux", "given": "Laure-Alix", "initials": "LA", "orcid": "0000-0003-2707-482X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/939248df1b6a46f38a59237a7b2f75dc.json"}}, {"family": "Albertini", "given": "Maria Cristina", "initials": "MC", "orcid": "0000-0003-4549-1475", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b634e74e14b45e5a0b9e9a36213a0a6.json"}}, {"family": "Amig\u00f3", "given": "N\u00faria", "initials": "N", "orcid": "0000-0002-0116-9145", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4d33dc1cbc84a7ba793dcc6db571cd2.json"}}, {"family": "Beronius", "given": "Anna", "initials": "A", "orcid": "0000-0001-9494-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9dd1a7937ff842d3943b11b4c3459f6e.json"}}, {"family": "Bezemer", "given": "Gillina F G", "initials": "GFG"}, {"family": "Coecke", "given": "Sandra", "initials": "S"}, {"family": "Daskalopoulos", "given": "Evangelos P", "initials": "EP"}, {"family": "Del Giudice", "given": "Giusy", "initials": "G"}, {"family": "Greco", "given": "Dario", "initials": "D", "orcid": "0000-0001-9195-9003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a1b8426cfa14677bf4f48740868c9a8.json"}}, {"family": "Grenga", "given": "Lucia", "initials": "L", "orcid": "0000-0001-5560-1717", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db628fe93ed94326869e52a86a47220c.json"}}, {"family": "Mantovani", "given": "Alberto", "initials": "A"}, {"family": "Mu\u00f1oz", "given": "Amalia", "initials": "A"}, {"family": "Omeragic", "given": "Elma", "initials": "E", "orcid": "0000-0002-5996-4926", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ab6ff466682485ebe5f7d0421b68e6e.json"}}, {"family": "Parissis", "given": "Nikolaos", "initials": "N", "orcid": "0000-0001-9478-0885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bff67e49a37d4969b4e88e8cc93344be.json"}}, {"family": "Petrillo", "given": "Mauro", "initials": "M", "orcid": "0000-0002-6782-4704", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8183c35e5c7b40d1a7ea56a85521451b.json"}}, {"family": "Saarim\u00e4ki", "given": "Laura A", "initials": "LA"}, {"family": "Soares", "given": "Helena", "initials": "H", "orcid": "0000-0002-5881-3843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f70a530898734960b5e71b665ecefedf.json"}}, {"family": "Sullivan", "given": "Kristie", "initials": "K"}, {"family": "Landesmann", "given": "Brigitte", "initials": "B"}], "type": "journal article", "published": "2022-07-31", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "11", "issue": "15", "issn-l": "2077-0383"}, "abstract": "Addressing factors modulating COVID-19 is crucial since abundant clinical evidence shows that outcomes are markedly heterogeneous between patients. This requires identifying the factors and understanding how they mechanistically influence COVID-19. Here, we describe how eleven selected factors (age, sex, genetic factors, lipid disorders, heart failure, gut dysbiosis, diet, vitamin D deficiency, air pollution and exposure to chemicals) influence COVID-19 by applying the Adverse Outcome Pathway (AOP), which is well-established in regulatory toxicology. This framework aims to model the sequence of events leading to an adverse health outcome. Several linear AOPs depicting pathways from the binding of the virus to ACE2 up to clinical outcomes observed in COVID-19 have been developed and integrated into a network offering a unique overview of the mechanisms underlying the disease. As SARS-CoV-2 infectibility and ACE2 activity are the major starting points and inflammatory response is central in the development of COVID-19, we evaluated how those eleven intrinsic and extrinsic factors modulate those processes impacting clinical outcomes. Applying this AOP-aligned approach enables the identification of current knowledge gaps orientating for further research and allows to propose biomarkers to identify of high-risk patients. This approach also facilitates expertise synergy from different disciplines to address public health issues.", "doi": "10.3390/jcm11154464", "pmid": "35956081", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jcm11154464"}, {"db": "pmc", "key": "PMC9369763"}], "notes": [], "created": "2022-08-16T15:41:27.289Z", "modified": "2022-08-16T15:41:48.989Z"}, {"entity": "publication", "iuid": "db6c2aa233d643e591911f4079de01cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db6c2aa233d643e591911f4079de01cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db6c2aa233d643e591911f4079de01cb"}}, "title": "VACCELERATE Volunteer Registry: A European study participant database to facilitate clinical trial enrolment.", "authors": [{"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J"}, {"family": "Stewart", "given": "Fiona A", "initials": "FA"}, {"family": "Heringer", "given": "Sarah", "initials": "S"}, {"family": "Koniordou", "given": "Markela", "initials": "M"}, {"family": "\u00c1lvarez-Barco", "given": "Elena", "initials": "E"}, {"family": "Argyropoulos", "given": "Christos D", "initials": "CD"}, {"family": "Themistocleous", "given": "Sophia C", "initials": "SC"}, {"family": "Valle-Sim\u00f3n", "given": "Paula", "initials": "P"}, {"family": "Spivak", "given": "Orly", "initials": "O"}, {"family": "Sou\u010dkov\u00e1", "given": "Lenka", "initials": "L"}, {"family": "Merakou", "given": "Christina", "initials": "C"}, {"family": "Am\u00e9lia Mendon\u00e7a", "given": "Maria", "initials": "M"}, {"family": "Joanna Davis", "given": "Ruth", "initials": "R"}, {"family": "Maria Azzini", "given": "Anna", "initials": "A"}, {"family": "Askling", "given": "Helena H", "initials": "HH"}, {"family": "Vene", "given": "Sirkka", "initials": "S"}, {"family": "Van Damme", "given": "Pierre", "initials": "P"}, {"family": "Steinbach", "given": "Angela", "initials": "A"}, {"family": "Shiamakkides", "given": "George", "initials": "G"}, {"family": "Seidel", "given": "Danila", "initials": "D"}, {"family": "Olesen", "given": "Ole F", "initials": "OF"}, {"family": "Noula", "given": "Evgenia", "initials": "E"}, {"family": "Macken", "given": "Alan", "initials": "A"}, {"family": "Lu\u00eds", "given": "Catarina", "initials": "C"}, {"family": "Leckler", "given": "Janina", "initials": "J"}, {"family": "Launay", "given": "Odile", "initials": "O"}, {"family": "Isitt", "given": "Catherine", "initials": "C"}, {"family": "Hellemans", "given": "Margot", "initials": "M"}, {"family": "Fr\u00edas-Iniesta", "given": "Jes\u00fas", "initials": "J"}, {"family": "Di Marzo", "given": "Romina", "initials": "R"}, {"family": "Carcas", "given": "Antonio J", "initials": "AJ"}, {"family": "Boustras", "given": "George", "initials": "G"}, {"family": "Borobia", "given": "Alberto M", "initials": "AM"}, {"family": "Barta", "given": "Imre", "initials": "I"}, {"family": "Albus", "given": "Kerstin", "initials": "K"}, {"family": "Akova", "given": "Murat", "initials": "M"}, {"family": "Ochando", "given": "Jordi", "initials": "J"}, {"family": "Cohen-Kandli", "given": "Miriam", "initials": "M"}, {"family": "Jane Cox", "given": "Rebecca", "initials": "R"}, {"family": "Husa", "given": "Petr", "initials": "P"}, {"family": "Jancoriene", "given": "Ligita", "initials": "L"}, {"family": "Mallon", "given": "Patrick", "initials": "P"}, {"family": "Marques", "given": "Laura", "initials": "L"}, {"family": "Mellinghoff", "given": "Sibylle C", "initials": "SC"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}, {"family": "Tacconelli", "given": "Evelina", "initials": "E"}, {"family": "T\u00f3th", "given": "Krisztina", "initials": "K"}, {"family": "Zaoutis", "given": "Theoklis E", "initials": "TE"}, {"family": "Zeitlinger", "given": "Markus", "initials": "M"}, {"family": "Cornely", "given": "Oliver A", "initials": "OA"}, {"family": "Pana", "given": "Zoi-Dorothea", "initials": "ZD"}, {"family": "VACCELERATE consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-29", "journal": {"title": "Vaccine", "issn": "1873-2518", "volume": "40", "issue": "31", "pages": "4090-4097", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has evidenced the key role of vaccine design, obtention, production and administration to successfully fight against infectious diseases and to provide efficient remedies for the citizens. Although clinical trials were rapidly established during this pandemic, identifying suitable study subjects can be challenging. For this reason, the University Hospital Cologne established a volunteer registry for participation in clinical trials first in Germany, which has now been incorporated into the European VACCELERATE clinical trials network and grew to a European Volunteer Registry. As such, VACCELERATE's Volunteer Registry aims to become a common entry point for potential volunteers in future clinical trials in Europe.\n\nInterested volunteers who would like to register for clinical trials in the VACCELERATE Volunteer Registry can access the registration questionnaire via http://www.vaccelerate.eu/volunteer-registry. Potential volunteers are requested to provide their current country and area of residence, contact information, including first and last name and e-mail address, age, gender, comorbidities, previous SARS-CoV-2 infection and vaccination status, and maximum distance willing to travel to a clinical trial site. The registry is open to both adults and children, complying with national legal consent requirements.\n\nAs of May 2022, the questionnaire is available in 12 countries and 14 languages. Up to date, more than 36,000 volunteers have registered, mainly from Germany. Within the first year since its establishment, the VACCELERATE Volunteer Registry has matched more than 15,000 volunteers to clinical trials. The VACCELERATE Volunteer Registry will be launched in further European countries in the coming months.\n\nThe VACCELERATE Volunteer Registry is an active single-entry point for European residents interested in COVID-19 clinical trials participation in 12 countries (i.e., Austria, Cyprus, Germany, Greece, Ireland, Lithuania, Norway, Portugal, Spain, Sweden and Turkey). To date, more than 15,000 registered individuals have been connected to clinical trials in Germany alone. The registry is currently in the implementation phase in 5 additional countries (i.e., Belgium, Czech Republic, Hungary, Israel and the Netherlands).", "doi": "10.1016/j.vaccine.2022.05.022", "pmid": "35659449", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(22)00605-3"}], "notes": [], "created": "2022-06-21T17:17:31.581Z", "modified": "2022-06-21T17:17:31.596Z"}, {"entity": "publication", "iuid": "bdf06c9002824a688b8b0092806ac1e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bdf06c9002824a688b8b0092806ac1e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bdf06c9002824a688b8b0092806ac1e1"}}, "title": "Serum concentration of extracellular cold-inducible RNA-binding protein is associated with respiratory failure in COVID-19.", "authors": [{"family": "Schagatay", "given": "Felix", "initials": "F"}, {"family": "Diamant", "given": "Klara", "initials": "K"}, {"family": "Lid\u00e9n", "given": "Mats", "initials": "M"}, {"family": "Edin", "given": "Alicia", "initials": "A"}, {"family": "Athlin", "given": "Simon", "initials": "S"}, {"family": "Hultgren", "given": "Olof", "initials": "O"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Savilampi", "given": "Johanna", "initials": "J"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Lange", "given": "Anna", "initials": "A"}, {"family": "Cajander", "given": "Sara", "initials": "S"}], "type": "journal article", "published": "2022-07-29", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "13", "pages": "945603", "issn-l": "1664-3224"}, "abstract": "Uncontrolled release of damage-associated molecular patterns (DAMPs) is suggested to be a major trigger for the dysregulated host immune response that leads to severe COVID-19. Cold-inducible RNA-binding protein (CIRP), is a newly identified DAMP that aggravates inflammation and tissue injury, and induces respiratory failure in sepsis. Whether CIRP contributes to the pathogenesis of respiratory failure in COVID-19 has not yet been explored.\n\nTo investigate if the concentration of extracellular CIRP (eCIRP) in serum associates with respiratory failure and lung involvement by chest computed tomography (CT) in COVID-19.\n\nHerein we report a prospective observational study of patients with COVID-19 included at two University Hospitals in Sweden between April 2020 and May 2021. Serum from hospitalized patients in \u00d6rebro (N=97) were used to assess the association between eCIRP and the level of respiratory support and its correlation with pulmonary involvement on chest CT and inflammatory biomarkers. A cohort of hospitalized and non-hospitalized patients from Ume\u00e5 (N=78) was used as an external validation cohort. The severity of disease was defined according to the highest degree of respiratory support; mild disease (no oxygen), non-severe hypoxemia (conventional oxygen or high-flow nasal oxygen, HFNO <50% FiO2), and severe hypoxemia (HFNO \u226550% FiO2, mechanical ventilation). Unadjusted and adjusted linear regression was used to evaluate peak eCIRP day 0-4 in respect to severity, age, sex, Charlson comorbidity score, symptom duration, and BMI.\n\nPeak eCIRP concentrations were higher in patients with severe hypoxemia and were independently associated with the degree of respiratory support in both cohorts (\u00d6rebro; p=0.01, Ume\u00e5; p<0.01). The degree of pulmonary involvement measured by CT correlated with eCIRP, rs=0.30, p<0.01 (n=97).\n\nHigh serum levels of eCIRP are associated with acute respiratory failure in COVID-19. Experimental studies are needed to determine if treatments targeting eCIRP reduces the risk of acute respiratory failure in COVID-19.", "doi": "10.3389/fimmu.2022.945603", "pmid": "35967397", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9373926"}], "notes": [], "created": "2022-08-16T15:37:26.634Z", "modified": "2022-08-19T05:27:23.777Z"}, {"entity": "publication", "iuid": "0d58d4714dae496c88ba1233e54f236e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d58d4714dae496c88ba1233e54f236e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d58d4714dae496c88ba1233e54f236e"}}, "title": "Healthy workplace onboard: Insights gained from the COVID-19 impact on mental health and wellbeing of seafarers.", "authors": [{"family": "Carrera-Arce", "given": "Maria", "initials": "M"}, {"family": "Bartusevi\u010dien\u0117", "given": "Inga", "initials": "I"}, {"family": "Divari", "given": "Paschalia", "initials": "P"}], "type": "journal article", "published": "2022-07-29", "journal": {"title": "Work", "issn": "1875-9270", "issn-l": null}, "abstract": "Seafarers' psychological health is seriously affected by COVID-19. The pandemic could act as a catalyst for change with respect to seafarers' mental health protection and promotion.\n\nThe study explores the main factors contributing to the mental health and wellbeing of seafarers. Moreover, elements to help seafarers lessen the impact of the pandemic on their work and life onboard are analyzed, and their role in developing a positive psychosocial environment and promoting a healthy workplace onboard are discussed.\n\nThe study involved the use of an ad hoc questionnaire and the adoption of both quantitative and qualitative methods. The sample included one hundred and five active seafarers.\n\nNinety-six percent of the sample stated that mental health is a very or extremely important part of their general health. Seafarers perceive that their mental health has been seriously impacted by COVID-19. Major factors contributing to seafarers' mental health and wellbeing reveal three groups of factors: rest and spare time-related factors, communication/relationship with the external world, and interaction and social life on board factors.\n\nStrategies suggested by seafarers for coping with \"inevitable\" psychological stress produced by COVID-19 and promoting their wellbeing include managerial, emotional, facilities-related (including communication infrastructure), physical, and social elements to promote wellbeing. Economic, intellectual, and spiritual elements also have to be taken into consideration and require further investigation. Building on seafarers' insights and experiences, a healthy environment onboard should cultivate holistically the four main spheres of a healthy workplace (physical work environment, psychosocial work environment, personal health resources, and enterprise community involvement) and the five features of a healthy psychosocial environment (social, emotional, physical, intellectual and spiritual) under all circumstances, whether exceptional or ordinary.", "doi": "10.3233/WOR-210791", "pmid": "35912771", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "WOR210791"}], "notes": [], "created": "2022-08-11T12:04:07.487Z", "modified": "2022-08-11T12:04:07.502Z"}, {"entity": "publication", "iuid": "853c5874292242dea1b45360476495d6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/853c5874292242dea1b45360476495d6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/853c5874292242dea1b45360476495d6"}}, "title": "Protein Expression Profile of ACE2 in the Normal and COVID-19-Affected Human Brain.", "authors": [{"family": "Lindskog", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-5611-1015", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4ead3d38a364b66ac069b9c8bf63897.json"}}, {"family": "M\u00e9ar", "given": "Loren", "initials": "L", "orcid": "0000-0001-9333-0110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/344121b8f2524853a820ad52ea8de328.json"}}, {"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "F\u00e4llmar", "given": "David", "initials": "D"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Hesselager", "given": "G\u00f6ran", "initials": "G"}, {"family": "Casar-Borota", "given": "Olivera", "initials": "O"}, {"family": "Rostami", "given": "Elham", "initials": "E"}], "type": "journal article", "published": "2022-07-28", "journal": {"title": "J Proteome Res", "issn": "1535-3907", "issn-l": null}, "abstract": "SARS-coronavirus 2 (SARS-CoV-2) that caused the coronavirus disease 2019 (COVID-19) pandemic has posed to be a global challenge. An increasing number of neurological symptoms have been linked to the COVID-19 disease, but the underlying mechanisms of such symptoms and which patients could be at risk are not yet established. The suggested key receptor for host cell entry is angiotensin I converting enzyme 2 (ACE2). Previous studies on limited tissue material have shown no or low protein expression of ACE2 in the normal brain. Here, we used stringently validated antibodies and immunohistochemistry to examine the protein expression of ACE2 in all major regions of the normal brain. The expression pattern was compared with the COVID-19-affected brain of patients with a varying degree of neurological symptoms. In the normal brain, the expression was restricted to the choroid plexus and ependymal cells with no expression in any other brain cell types. Interestingly, in the COVID-19-affected brain, an upregulation of ACE2 was observed in endothelial cells of certain patients, most prominently in the white matter and with the highest expression observed in the patient with the most severe neurological symptoms. The data shows differential expression of ACE2 in the diseased brain and highlights the need to further study the role of endothelial cells in COVID-19 disease in relation to neurological symptoms.", "doi": "10.1021/acs.jproteome.2c00184", "pmid": "35901083", "labels": {"Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9364976"}], "notes": [], "created": "2022-08-12T08:32:57.108Z", "modified": "2022-08-12T08:32:57.176Z"}, {"entity": "publication", "iuid": "fd6adaa59c1f4e41bc3b8161bc015a7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fd6adaa59c1f4e41bc3b8161bc015a7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fd6adaa59c1f4e41bc3b8161bc015a7e"}}, "title": "From novel discovery tools and biomarkers to precision medicine - basic cardiovascular science highlights of 2021/2022.", "authors": [{"family": "Evans", "given": "Paul C", "initials": "PC", "orcid": "0000-0001-7975-681X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9bbd82269e844d92bdb953d9544fbc84.json"}}, {"family": "Davidson", "given": "Sean M", "initials": "SM"}, {"family": "Wojta", "given": "Johann", "initials": "J", "orcid": "0000-0002-1282-9276", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceed4186b4864c1e83d4dbaa35465b2c.json"}}, {"family": "B\u00e4ck", "given": "Magnus", "initials": "M"}, {"family": "Bollini", "given": "Sveva", "initials": "S"}, {"family": "Brittan", "given": "Mairi", "initials": "M", "orcid": "0000-0002-3830-200X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41994a2430ff4dfc82a5e2b95da0cef2.json"}}, {"family": "Catapano", "given": "Alberico L", "initials": "AL", "orcid": "0000-0002-7593-2094", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9be6543658dc4243b3692badcfb51112.json"}}, {"family": "Chaudhry", "given": "Bill", "initials": "B"}, {"family": "Cluitmans", "given": "Matthijs", "initials": "M"}, {"family": "Gnecchi", "given": "Massimiliano", "initials": "M", "orcid": "0000-0001-7435-4328", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b080766181f34bc6aaa22bf38a356839.json"}}, {"family": "Guzik", "given": "Tomasz J", "initials": "TJ", "orcid": "0000-0003-2012-1187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bba211a5749d45668559282301691367.json"}}, {"family": "Hoefer", "given": "Imo", "initials": "I"}, {"family": "Madonna", "given": "Rosalinda", "initials": "R", "orcid": "0000-0001-6455-2777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/628e83f26bb44f578c343e8801a9c848.json"}}, {"family": "Monteiro", "given": "Jo\u00e3o P", "initials": "JP"}, {"family": "Morawietz", "given": "Henning", "initials": "H"}, {"family": "Osto", "given": "Elena", "initials": "E", "orcid": "0000-0001-8196-5696", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8748792f9b8b412abbe0bdb9f5339adb.json"}}, {"family": "Padr\u00f3", "given": "Teresa", "initials": "T"}, {"family": "Sluimer", "given": "Judith C", "initials": "JC"}, {"family": "Tocchetti", "given": "Carlo Gabriele", "initials": "CG"}, {"family": "Van der Heiden", "given": "Kim", "initials": "K", "orcid": "0000-0002-6537-5992", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3450039095254822b1b3fae6a9b70720.json"}}, {"family": "Vilahur", "given": "Gemma", "initials": "G"}, {"family": "Waltenberger", "given": "Johannes", "initials": "J", "orcid": "0000-0002-2417-9880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92915958f5aa420d9562819756473451.json"}}, {"family": "Weber", "given": "Christian", "initials": "C", "orcid": "0000-0003-4610-8714", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c44b7ca02c624d62be15c61fcf389d54.json"}}], "type": "journal article", "published": "2022-07-28", "journal": {"title": "Cardiovasc Res", "issn": "1755-3245", "issn-l": null}, "abstract": "Here we review the highlights of cardiovascular basic science in published in 2021 and early 2022 on behalf of the European Society of Cardiology Council for Basic Cardiovascular Science. We begin with non-coding RNAs which have emerged as central regulators cardiovascular biology, and then discuss how technological developments in single-cell 'omics are providing new insights in cardiovascular development, inflammation and disease. We also review recent discoveries on the biology of extracellular vesicles in driving either protective or pathogenic responses. The Nobel Prize in Physiology or Medicine 2021 recognised the importance of the molecular basis of mechanosensing and here we review breakthroughs in cardiovascular sensing of mechanical force. We also summarise discoveries in the field of atherosclerosis including the role of clonal haematopoiesis of indeterminate potential, and new mechanisms of cross-talk between hyperglycemia, lipid mediators and inflammation. The past 12 months also witnessed major advances in the field of cardiac arrhythmia including new mechanisms of fibrillation. We also focus on inducible pluripotent stem cell (iPSC) technology which has demonstrated disease causality for several genetic polymorphisms in long QT syndrome and aortic valve disease, paving the way for personalized medicine approaches. Finally, the cardiovascular community has continued to better understand COVID-19 with significant advancement in our knowledge of cardiovascular tropism, molecular markers, the mechanism of vaccine-induced thrombotic complications and new anti-viral therapies that protect the cardiovascular system.", "doi": "10.1093/cvr/cvac114", "pmid": "35899362", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6650923"}], "notes": [], "created": "2022-08-12T08:33:39.207Z", "modified": "2022-08-12T08:33:39.606Z"}, {"entity": "publication", "iuid": "ac4dffd654da4755949ea87002895b09", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac4dffd654da4755949ea87002895b09.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac4dffd654da4755949ea87002895b09"}}, "title": "Sociodemographic and Occupational Factors Associated with Low Early Uptake of COVID-19 Vaccine in Hospital-Based Healthcare Workers, Georgia, March-July 2021.", "authors": [{"family": "Lucaccioni", "given": "H\u00e9lo\u00efse", "initials": "H", "orcid": "0000-0003-3080-9794", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5850aabf8a674ee2971fe111b880aeba.json"}}, {"family": "Chakhunashvili", "given": "Giorgi", "initials": "G"}, {"family": "McKnight", "given": "Carl Jason", "initials": "CJ"}, {"family": "Zardiashvili", "given": "Tamila", "initials": "T"}, {"family": "Jorgensen", "given": "Pernille", "initials": "P"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "Kissling", "given": "Esther", "initials": "E"}, {"family": "Katz", "given": "Mark A", "initials": "MA", "orcid": "0000-0002-5532-7276", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/890f00845e274820b1b78a0829f4d01f.json"}}, {"family": "Sanodze", "given": "Lia", "initials": "L"}], "type": "journal article", "published": "2022-07-27", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "In Georgia, an upper-middle income European country, the COVID-19 vaccine rollout began on 15 March 2021 with health workers (HWs), a priority group for vaccination. We assessed the factors associated with COVID-19 vaccination among HWs at six large hospitals in the early stages of the vaccine rollout (March-July 2021). Among 1533 HWs, 274 (17.9%) had received one dose of the COVID-19 vaccine. Strong independent predictors of early vaccine uptake were age &gt; 40 years, especially 50-59 years old (aOR 2.40, 95% CI 1.50-3.88), considering the vaccine as \"somewhat effective\" or \"very effective\" rather than \"not effective\" (aOR 6.33, 95% CI 2.29-26.3 and aOR 10.9, 95% CI 3.88-45.70, respectively), and previous vaccination against seasonal influenza (aOR 2.98, 95% CI 2.19-4.08). Previous SARS-CoV-2 infection was negatively associated with receiving the vaccine (aOR 0.6, 95% CI 0.40-0.80). Compared to physicians, nurses/midwives (aOR 0.22, 95% CI 0.15-0.32), administrative staff (aOR 0.36, 95% CI 0.22-0.56), and ancillary staff (aOR 0.07, 95% CI 0.04-0.15) were less likely to have received the COVID-19 vaccine. Tailoring the COVID-19 vaccine communications campaign to younger and non-physician HWs, and emphasizing the benefits of the COVID-19 vaccine, could help further increase vaccine coverage among HWs in Georgia.", "doi": "10.3390/vaccines10081197", "pmid": "36016084", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "vaccines10081197"}, {"db": "pmc", "key": "PMC9415840"}], "notes": [], "created": "2022-09-12T19:09:52.564Z", "modified": "2022-09-12T19:10:59.840Z"}, {"entity": "publication", "iuid": "838d5e0781814dc0b5b565581bd02829", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/838d5e0781814dc0b5b565581bd02829.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/838d5e0781814dc0b5b565581bd02829"}}, "title": "Silence Among First-Line Managers in Eldercare and Their Continuous Improvement Work During Covid-19.", "authors": [{"family": "Dellve", "given": "Lotta", "initials": "L", "orcid": "0000-0003-0480-1895", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/796e0052b7eb49629ac24f9fc455ce5a.json"}}, {"family": "Jendeby", "given": "Mimmi Kheddache", "initials": "MK", "orcid": "0000-0002-9756-0607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef79afa452a845f18b07a3963567e045.json"}}], "type": "journal article", "published": "2022-07-27", "journal": {"title": "Inquiry", "issn": "1945-7243", "volume": "59", "pages": "469580221107052", "issn-l": null}, "abstract": "Eldercare sector faced severe needs, and unexplained difficulties, to manage daily work and the continuous improvement of routines at operative levels during Covid-19. First-line managers in eldercare have a key role to facilitate learnings but may be hindered in public, hierarchical organizations. This is the first study on the conditions and importance of silence for managerial work in terms of daily operations and continuous improvement work. To identify first-line managers' silence in eldercare, its contextual and supportive conditions, its reasons and its implications for managerial work with regard to daily operations and continuous improvement work. Mixed-method study based on a questionnaire to first-line managers (n = 189) in Swedish public eldercare in 33 randomly selected municipal organizations and one city. The instruments Communication of Critical Issues at Work, Managers Stress Inventory and Managerial Work and an open question were analyzed using: (1) qualitative coding to explore organizational conditions, (2) descriptive statistics, and (3) stepwise regressions to identify associations. The most common forms of silence were quiescent (based on fear of the consequences of speaking up) and acquiescent (based on resignation and demotivation). Organizational conditions shaping managerial silence were due to strict governance and control in a hierarchical organization, lack of support and participation in decision-making and the experience of not being valued. Managers' silence had a negative impact on managerial work and especially work on continuous improvements. The pandemic also offered space for values of occupational professionalism and learning at operational levels. Organizational conditions of support through superiors and management teams decreased silence. Manager silence is detrimental for continuous improvement work and may arise in organizations with dominant values of organizational professionalism. Supportive conditions based on trust and space for occupational professionalism may be important and should be improved to decrease managerial silence and better support continuous improvements.", "doi": "10.1177/00469580221107052", "pmid": "35880855", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9340405"}], "notes": [], "created": "2022-08-12T08:38:02.656Z", "modified": "2022-08-12T08:38:02.745Z"}, {"entity": "publication", "iuid": "38d6d243fdea4bc899b9df57c001eb57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38d6d243fdea4bc899b9df57c001eb57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38d6d243fdea4bc899b9df57c001eb57"}}, "title": "NMR Experiments Provide Insights into Ligand-Binding to the SARS-CoV-2 Spike Protein Receptor-Binding Domain.", "authors": [{"family": "Creutznacher", "given": "Robert", "initials": "R"}, {"family": "Maass", "given": "Thorben", "initials": "T"}, {"family": "Veselkova", "given": "Barbora", "initials": "B"}, {"family": "Ssebyatika", "given": "George", "initials": "G"}, {"family": "Krey", "given": "Thomas", "initials": "T"}, {"family": "Empting", "given": "Martin", "initials": "M"}, {"family": "Tautz", "given": "Norbert", "initials": "N"}, {"family": "Frank", "given": "Martin", "initials": "M"}, {"family": "K\u00f6lbel", "given": "Knut", "initials": "K"}, {"family": "Uetrecht", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1991-7922", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb624da1299f4c7fb23cbb6ed98d5338.json"}}, {"family": "Peters", "given": "Thomas", "initials": "T", "orcid": "0000-0002-7570-8260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f8c890c3f7e4b1688e247f1920fafa8.json"}}], "type": "journal article", "published": "2022-07-27", "journal": {"title": "J Am Chem Soc", "issn": "1520-5126", "volume": "144", "issue": "29", "pages": "13060-13065", "issn-l": null}, "abstract": "We have used chemical shift perturbation (CSP) and saturation transfer difference (STD) NMR experiments to identify and characterize the binding of selected ligands to the receptor-binding domain (RBD) of the spike glycoprotein (S-protein) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We also subjected full-length S-protein to STD NMR experiments, allowing correlations with RBD-based results. CSPs reveal the binding sites for heparin and fondaparinux, and affinities were measured using CSP titrations. We then show that \u03b1-2,3-sialyllactose binds to the S-protein but not to the RBD. Finally, combined CSP and STD NMR experiments show that lifitegrast, a compound used for the treatment of dry eye, binds to the linoleic acid (LA) binding pocket with a dissociation constant in the \u03bcM range. This is an interesting finding, as lifitegrast lends itself well as a blueprint for medicinal chemistry, eventually furnishing novel entry inhibitors targeting the highly conserved LA binding site.", "doi": "10.1021/jacs.2c05603", "pmid": "35830336", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-17T10:35:23.171Z", "modified": "2022-08-17T10:36:02.991Z"}, {"entity": "publication", "iuid": "65043fd61ce841a99504d2db8c4cb5e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65043fd61ce841a99504d2db8c4cb5e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65043fd61ce841a99504d2db8c4cb5e8"}}, "title": "Macrotroponin Complex as a Cause for Cardiac Troponin Increase after COVID-19 Vaccination and Infection.", "authors": [{"family": "Bularga", "given": "Anda", "initials": "A", "orcid": "0000-0002-5530-527X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91b19a9407f94a29aaa1c010933a5971.json"}}, {"family": "Oskoui", "given": "Ellen", "initials": "E"}, {"family": "Fujisawa", "given": "Takeshi", "initials": "T"}, {"family": "Jenks", "given": "Sara", "initials": "S"}, {"family": "Sutherland", "given": "Rachel", "initials": "R"}, {"family": "Apple", "given": "Fred S", "initials": "FS"}, {"family": "Hammarsten", "given": "Ola", "initials": "O"}, {"family": "Mills", "given": "Nicholas L", "initials": "NL", "orcid": "0000-0003-0533-7991", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c76e317e697744878fd74d19e720df4c.json"}}], "type": "journal article", "published": "2022-07-27", "journal": {"title": "Clin Chem", "issn": "1530-8561", "volume": "68", "issue": "8", "pages": "1015-1019", "issn-l": "0009-9147"}, "abstract": null, "doi": "10.1093/clinchem/hvac100", "pmid": "35896175", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6650785"}], "notes": [], "created": "2022-08-12T08:34:39.276Z", "modified": "2022-08-12T08:34:39.362Z"}, {"entity": "publication", "iuid": "fab6ff995328484bb42b4f6f4ee2375f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fab6ff995328484bb42b4f6f4ee2375f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fab6ff995328484bb42b4f6f4ee2375f"}}, "title": "Hypertension in COVID-19, A Risk Factor for Infection or A Late Consequence?", "authors": [{"family": "Barekat", "given": "Maryam", "initials": "M"}, {"family": "Shahrbaf", "given": "Mohammad Amin", "initials": "MA"}, {"family": "Rahi", "given": "Kosar", "initials": "K"}, {"family": "Vosough", "given": "Massoud", "initials": "M"}], "type": "journal article", "published": "2022-07-27", "journal": {"title": "Cell J", "issn": "2228-5806", "volume": "24", "issue": "7", "pages": "424-426", "issn-l": null}, "abstract": "There are a lot of data about the correlation of SARS-CoV-2 infection and hypertension (HTN), but most of them are in the increased risk of morbidity and mortality in patients with HTN. SARS-CoV-2 can interfere with host cells through the renin-angiotensin system (RAS) via the angiotensin-converting enzyme 2 (ACE2) receptor. RAS activation is associated with pro-inflammatory effects through the ACE/Ang II/ Angiotensin II type 1 receptor (AT1R) pathway or anti-inflammatory effects through ACE2/Ang1-7/Mas axis. In the current paper, we discuss the pathophysiology of newly diagnosed HTN and its effect on morbidity in patients with coronavirus disease 2019 (COVID-19).", "doi": "10.22074/cellj.2022.8487", "pmid": "36043411", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9428472"}], "notes": [], "created": "2022-10-13T13:05:46.781Z", "modified": "2022-10-13T13:05:46.809Z"}, {"entity": "publication", "iuid": "e78151a5b69344e8ab24d133a2f328e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e78151a5b69344e8ab24d133a2f328e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e78151a5b69344e8ab24d133a2f328e8"}}, "title": "Transient and durable T cell reactivity after COVID-19.", "authors": [{"family": "Martner", "given": "Anna", "initials": "A", "orcid": "0000-0002-6598-5221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c11a2e719c534772a129782bfb60d35c.json"}}, {"family": "Grauers Wiktorin", "given": "Hanna", "initials": "H", "orcid": "0000-0002-4412-5695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a08f604e1f94feda4e60f01d728e68f.json"}}, {"family": "T\u00f6rnell", "given": "Andreas", "initials": "A", "orcid": "0000-0003-0769-2815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0e49354b88f4f7c8792dfb4216561c8.json"}}, {"family": "Ringlander", "given": "Johan", "initials": "J", "orcid": "0000-0002-8483-6504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64f85af7dceb436498422e62f1a98c89.json"}}, {"family": "Arabpour", "given": "Mohammad", "initials": "M"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-6617-5976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7bda9f192dc44c587d8a252ef16516b.json"}}], "type": "journal article", "published": "2022-07-26", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "119", "issue": "30", "pages": "e2203659119", "issn-l": "0027-8424"}, "abstract": "This study analyzed whole blood samples (n = 56) retrieved from 30 patients at 1 to 21 (median 9) mo after verified COVID-19 to determine the polarity and duration of antigen-specific T cell reactivity against severe acute respiratory syndrome coronavirus 2-derived antigens. Multimeric peptides spanning the entire nucleocapsid protein triggered strikingly synchronous formation of interleukin (IL)-4, IL-12, IL-13, and IL-17 ex vivo until \u223c70 d after confirmed infection, whereafter this reactivity was no longer inducible. In contrast, levels of nucleocapsid-induced IL-2 and interferon-\u03b3 remained stable and highly correlated at 3 to 21 mo after infection. Similar cytokine dynamics were observed in unvaccinated, convalescent patients using whole-blood samples stimulated with peptides spanning the N-terminal portion of the spike 1 protein. These results unravel two phases of T cell reactivity following natural COVID-19: an early, synchronous response indicating transient presence of multipolar, antigen-specific T helper (TH) cells followed by an equally synchronous and durable TH1-like reactivity reflecting long-lasting T cell memory.", "doi": "10.1073/pnas.2203659119", "pmid": "35858456", "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9335198"}], "notes": [], "created": "2022-08-12T08:44:58.936Z", "modified": "2022-08-12T08:45:19.541Z"}, {"entity": "publication", "iuid": "9fab4c18e8884e05879f96f6e51a805a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9fab4c18e8884e05879f96f6e51a805a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9fab4c18e8884e05879f96f6e51a805a"}}, "title": "Examining the relationship between alcohol consumption, psychological distress and COVID-19 related circumstances: An Australian longitudinal study in the first year of the pandemic.", "authors": [{"family": "Mojica-Perez", "given": "Yvette", "initials": "Y"}, {"family": "Livingston", "given": "Michael", "initials": "M"}, {"family": "Pennay", "given": "Amy", "initials": "A"}, {"family": "Callinan", "given": "Sarah", "initials": "S"}], "type": "journal article", "published": "2022-07-26", "journal": {"title": "Addict Behav", "issn": "1873-6327", "volume": "135", "pages": "107439", "issn-l": null}, "abstract": "The aim of this study is to examine the relationship between alcohol consumption, psychological distress and COVID-19 related circumstances (being in lockdown, working from home, providing home-schooling and being furloughed) over the first eight months of the pandemic in Australia.\n\nA longitudinal study with six survey waves over eight months with a convenience sample of 770 participants. Participants were aged 18 or over, lived in Australia and consumed alcohol at least monthly. Demographic data was obtained in the first wave. Data on alcohol consumption, psychological distress (Kessler 10), and COVID-19 related circumstances (being in lockdown, working from home, providing home-schooling and being furloughed) were obtained in each survey wave.\n\nResults from the fixed-effect bivariate regression analyses show that participants reported greater alcohol consumption when they had high psychological distress compared to when they had low psychological distress. Meanwhile, participants reported greater alcohol consumption when they worked from home compared to when they did not work from home. Participants also reported greater alcohol consumption when they provided home-schooling compared with when they did not provide home-schooling. The fixed-effect panel multivariable regression analyses indicated a longitudinal relationship between higher psychological distress and providing home-schooling on increased alcohol consumption.\n\nBroader drinking trends during the COVID-19 pandemic typically indicate increases and decreases in drinking among different members of the population. This study demonstrates that in Australia, it was those who experienced psychological distress and specific impacts of COVID-19 restrictions that were more likely to increase their drinking.", "doi": "10.1016/j.addbeh.2022.107439", "pmid": "35914417", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0306-4603(22)00205-2"}, {"db": "pmc", "key": "PMC9316938"}], "notes": [], "created": "2022-08-11T12:03:50.721Z", "modified": "2022-08-11T12:03:50.763Z"}, {"entity": "publication", "iuid": "081d960b8d3d42cfa84e0fbd8d246cd8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/081d960b8d3d42cfa84e0fbd8d246cd8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/081d960b8d3d42cfa84e0fbd8d246cd8"}}, "title": "Assessing the effectiveness of public health interventions for Covid-19 in Greece and Cyprus.", "authors": [{"family": "Zahariadis", "given": "Nikolaos", "initials": "N"}, {"family": "Exadaktylos", "given": "Theofanis", "initials": "T"}, {"family": "Sparf", "given": "J\u00f6rgen", "initials": "J"}, {"family": "Petridou", "given": "Evangelia", "initials": "E"}, {"family": "Kyriakidis", "given": "Alexandros", "initials": "A"}, {"family": "Papadopoulos", "given": "Ioannis", "initials": "I"}], "type": "journal article", "published": "2022-07-26", "journal": {"title": "Eur Policy Anal", "issn": "2380-6567", "issn-l": null}, "abstract": "In this article, we statistically examine the effectiveness of non-pharmaceutical interventions (NPIs) implemented by the national governments of Greece and Cyprus during 2020 to (a) limit the spread of the SARS-CoV-2 virus, and (b) mitigate the economic fallout brought about by the Covid-19 pandemic. Applying a modified health belief model, we hypothesize that behavioral outcomes at the policy level are a function of NPIs, perceived severity, and social context. We employ a Prais-Winsten estimation in 2-week averages and report panel-corrected standard errors to find that NPIs have clear, yet differential, effects on public health and the economy in terms of statistical significance and time lags. The study provides a critical framework to inform future interventions during emerging pandemics.", "doi": "10.1002/epa2.1153", "pmid": "35942067", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "EPA21153"}, {"db": "pmc", "key": "PMC9349912"}], "notes": [], "created": "2022-08-11T11:49:57.708Z", "modified": "2022-08-11T11:50:13.852Z"}, {"entity": "publication", "iuid": "b1eda1cb4a3a4ebd9a243040fd49a220", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1eda1cb4a3a4ebd9a243040fd49a220.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1eda1cb4a3a4ebd9a243040fd49a220"}}, "title": "Adolescents' Experience of Stress: A Focus Group Interview Study with 16-19-Year-Old Students during the COVID-19 Pandemic.", "authors": [{"family": "Perming", "given": "Camilla", "initials": "C"}, {"family": "Thurn", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Garmy", "given": "Pernilla", "initials": "P", "orcid": "0000-0003-1643-0171", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc4733a9e87a42fea6e7a7323feb61b3.json"}}, {"family": "Einberg", "given": "Eva-Lena", "initials": "EL", "orcid": "0000-0002-5586-3810", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d67e636861d492fb682ec1601422cd0.json"}}], "type": "journal article", "published": "2022-07-26", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "15", "issn-l": null}, "abstract": "The purpose was to investigate stress among adolescents (16-19 years old) during the coronavirus disease 2019 (COVID-19) pandemic. Focus group (n = 9) interviews with students at upper secondary schools (16-19 years old, n = 41) were conducted in southern Sweden during the COVID-19 pandemic in 2021. The interviews were analyzed by qualitative content analysis. The analysis revealed five categories of experience of stress: (1) School-related stress, (2) Stress in relationships and leisure, (3) How stress manifests itself, (4) Stress can increase performance, and (5) Experiences of counteracting stress. The adolescents in the study experienced stress linked to school and relationships, partly due to the COVID-19 pandemic. Distance education during the COVID-19 pandemic increased stress levels. The adolescents stated that high stress levels were experienced negatively and impaired their ability to perform, while moderate stress could contribute to achieving goals and improving performance. School nurses and other health professionals who meet with adolescents are important to support adolescents experiencing stress.", "doi": "10.3390/ijerph19159114", "pmid": "35897483", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19159114"}, {"db": "pmc", "key": "PMC9331051"}], "notes": [], "created": "2022-08-12T08:34:09.420Z", "modified": "2022-08-12T08:34:09.460Z"}, {"entity": "publication", "iuid": "27e5c782afdf4fc3a0742d51b72f6c3a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27e5c782afdf4fc3a0742d51b72f6c3a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27e5c782afdf4fc3a0742d51b72f6c3a"}}, "title": "The Inhibitory Potential of Ferulic Acid Derivatives against the SARS-CoV-2 Main Protease: Molecular Docking, Molecular Dynamics, and ADMET Evaluation.", "authors": [{"family": "Antonopoulou", "given": "Io", "initials": "I", "orcid": "0000-0002-7754-9398", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b07903ae8ac9453ca0e9b1005ab2137e.json"}}, {"family": "Sapountzaki", "given": "Eleftheria", "initials": "E"}, {"family": "Rova", "given": "Ulrika", "initials": "U", "orcid": "0000-0001-7500-2367", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9d7082ee4c84d308472242f35055e9f.json"}}, {"family": "Christakopoulos", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2022-07-25", "journal": {"title": "Biomedicines", "issn": "2227-9059", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "The main protease (Mpro) of SARS-CoV-2 is an appealing target for the development of antiviral compounds, due to its critical role in the viral life cycle and its high conservation among different coronaviruses and the continuously emerging mutants of SARS-CoV-2. Ferulic acid (FA) is a phytochemical with several health benefits that is abundant in plant biomass and has been used as a basis for the enzymatic or chemical synthesis of derivatives with improved properties, including antiviral activity against a range of viruses. This study tested 54 reported FA derivatives for their inhibitory potential against Mpro by in silico simulations. Molecular docking was performed using Autodock Vina, resulting in comparable or better binding affinities for 14 compounds compared to the known inhibitors N3 and GC376. ADMET analysis showed limited bioavailability but significantly improved the solubility for the enzymatically synthesized hits while better bioavailability and druglikeness properties but higher toxicity were observed for the chemically synthesized ones. MD simulations confirmed the stability of the complexes of the most promising compounds with Mpro, highlighting FA rutinoside and compound e27 as the best candidates from each derivative category.", "doi": "10.3390/biomedicines10081787", "pmid": "35892687", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "biomedicines10081787"}, {"db": "pmc", "key": "PMC9329733"}], "notes": [], "created": "2022-08-12T08:34:56.494Z", "modified": "2022-08-12T08:34:56.598Z"}, {"entity": "publication", "iuid": "2803bd89db79418ebbde0e679249a6bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2803bd89db79418ebbde0e679249a6bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2803bd89db79418ebbde0e679249a6bf"}}, "title": "Inflammatory mediators profile in patients hospitalized with COVID-19: A comparative study.", "authors": [{"family": "Tufa", "given": "Abdisa", "initials": "A"}, {"family": "Gebremariam", "given": "Tewodros Haile", "initials": "TH"}, {"family": "Manyazewal", "given": "Tsegahun", "initials": "T"}, {"family": "Getinet", "given": "Tewodros", "initials": "T"}, {"family": "Webb", "given": "Dominic-Luc", "initials": "DL"}, {"family": "Hellstr\u00f6m", "given": "Per M", "initials": "PM"}, {"family": "Genet", "given": "Solomon", "initials": "S"}], "type": "journal article", "published": "2022-07-25", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "13", "pages": "964179", "issn-l": "1664-3224"}, "abstract": "Abnormal inflammatory mediator concentrations during SARS-CoV-2 infection may represent disease severity. We aimed to assess plasma inflammatory mediator concentrations in patients with SARS-CoV-2 in Addis Ababa, Ethiopia. In this study, 260 adults: 126 hospitalized patients with confirmed COVID-19 sorted into severity groups: severe (n=68) and mild or moderate (n=58), and 134 healthy controls were enrolled. We quantified 39 plasma inflammatory mediators using multiplex ELISA. Spearman rank correlation and Mann-Whitney U test were used to identify mechanistically coupled inflammatory mediators and compare disease severity. Compared to healthy controls, patients with COVID-19 had significantly higher levels of interleukins 1\u03b1, 2, 6, 7, 8, 10 and 15, C-reactive protein (CRP), serum amyloid A (SAA), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion protein 1 (VCAM-1), IFN-\u03b3-inducible protein-10 (IP-10, CXCL10), macrophage inflammatory protein-1 alpha (MIP-1\u03b1, CCL3), eotaxin-3 (CCL26), interferon-gamma (IFN-\u03b3), tumor necrosis factor-\u03b1 (TNF-\u03b1), basic fibroblast growth factor (bFGF), placental growth factor (PlGF), and fms-like tyrosine kinase 1 (Flt-1). Patients with severe COVID-19 had higher IL-10 and lower macrophage-derived chemokine (MDC, CCL22) compared to the mild or moderate group (P<0.05). In the receiver operating characteristic curve, SAA, IL-6 and CRP showed strong sensitivity and specificity in predicting the severity and prognosis of COVID-19. Greater age and higher CRP had a significant association with disease severity (P<0.05). Our findings reveal that CRP, SAA, VCAM-1, CXCL10, CCL22 and IL-10 levels are promising biomarkers for COVID-19 disease severity, suggesting that plasma inflammatory mediators could be used as warning indicators of COVID-19 severity, aid in COVID-19 prognosis and treatment.", "doi": "10.3389/fimmu.2022.964179", "pmid": "35958594", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC9359079"}], "notes": [], "created": "2022-08-16T15:40:42.715Z", "modified": "2022-08-16T15:40:48.502Z"}, {"entity": "publication", "iuid": "e423ccc6f6ef417e9c25f79beb912f33", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e423ccc6f6ef417e9c25f79beb912f33.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e423ccc6f6ef417e9c25f79beb912f33"}}, "title": "Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study.", "authors": [{"family": "Izadi", "given": "Zara", "initials": "Z"}, {"family": "Gianfrancesco", "given": "Milena A", "initials": "MA"}, {"family": "Schmajuk", "given": "Gabriela", "initials": "G"}, {"family": "Jacobsohn", "given": "Lindsay", "initials": "L"}, {"family": "Katz", "given": "Patricia", "initials": "P"}, {"family": "Rush", "given": "Stephanie", "initials": "S"}, {"family": "Ja", "given": "Clairissa", "initials": "C"}, {"family": "Taylor", "given": "Tiffany", "initials": "T"}, {"family": "Shidara", "given": "Kie", "initials": "K"}, {"family": "Danila", "given": "Maria I", "initials": "MI"}, {"family": "Wysham", "given": "Katherine D", "initials": "KD"}, {"family": "Strangfeld", "given": "Anja", "initials": "A"}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL"}, {"family": "Gossec", "given": "Laure", "initials": "L"}, {"family": "Carmona", "given": "Loreto", "initials": "L"}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S"}, {"family": "Kearsley-Fleet", "given": "Lianne", "initials": "L"}, {"family": "Schaefer", "given": "Martin", "initials": "M"}, {"family": "Al-Emadi", "given": "Samar", "initials": "S"}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA"}, {"family": "Hsu", "given": "Tiffany Y-T", "initials": "TY"}, {"family": "Patel", "given": "Naomi J", "initials": "NJ"}, {"family": "Wise", "given": "Leanna", "initials": "L"}, {"family": "Gilbert", "given": "Emily", "initials": "E"}, {"family": "Duarte-Garc\u00eda", "given": "Al\u00ed", "initials": "A"}, {"family": "Valenzuela-Almada", "given": "Maria O", "initials": "MO"}, {"family": "Ugarte-Gil", "given": "Manuel F", "initials": "MF"}, {"family": "Ljung", "given": "Lotta", "initials": "L"}, {"family": "Scir\u00e8", "given": "Carlo A", "initials": "CA"}, {"family": "Carrara", "given": "Greta", "initials": "G"}, {"family": "Hachulla", "given": "Eric", "initials": "E"}, {"family": "Richez", "given": "Christophe", "initials": "C"}, {"family": "Cacoub", "given": "Patrice", "initials": "P"}, {"family": "Thomas", "given": "Thierry", "initials": "T"}, {"family": "Santos", "given": "Maria J", "initials": "MJ"}, {"family": "Bernardes", "given": "Miguel", "initials": "M"}, {"family": "Hasseli", "given": "Rebecca", "initials": "R"}, {"family": "Regierer", "given": "Anne", "initials": "A"}, {"family": "Schulze-Koops", "given": "Hendrik", "initials": "H"}, {"family": "M\u00fcller-Ladner", "given": "Ulf", "initials": "U"}, {"family": "Pons-Estel", "given": "Guillermo", "initials": "G"}, {"family": "Tanten", "given": "Romina", "initials": "R"}, {"family": "Nieto", "given": "Romina E", "initials": "RE"}, {"family": "Pisoni", "given": "Cecilia N", "initials": "CN"}, {"family": "Tissera", "given": "Yohana S", "initials": "YS"}, {"family": "Xavier", "given": "Ricardo", "initials": "R"}, {"family": "Lopes Marques", "given": "Claudia D", "initials": "CD"}, {"family": "Pileggi", "given": "Gecilmara C S", "initials": "GCS"}, {"family": "Robinson", "given": "Philip C", "initials": "PC"}, {"family": "Machado", "given": "Pedro M", "initials": "PM"}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS"}, {"family": "Sufka", "given": "Paul", "initials": "P"}, {"family": "Grainger", "given": "Rebecca", "initials": "R"}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Gore-Massy", "given": "Monique", "initials": "M"}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Yazdany", "given": "Jinoos", "initials": "J"}, {"family": "COVID-19 Global Rheumatology Alliance Registry", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-25", "journal": {"title": "Lancet Rheumatol", "issn": "2665-9913", "issn-l": null}, "abstract": "Differences in the distribution of individual-level clinical risk factors across regions do not fully explain the observed global disparities in COVID-19 outcomes. We aimed to investigate the associations between environmental and societal factors and country-level variations in mortality attributed to COVID-19 among people with rheumatic disease globally.\n\nIn this observational study, we derived individual-level data on adults (aged 18-99 years) with rheumatic disease and a confirmed status of their highest COVID-19 severity level from the COVID-19 Global Rheumatology Alliance (GRA) registry, collected between March 12, 2020, and Aug 27, 2021. Environmental and societal factors were obtained from publicly available sources. The primary endpoint was mortality attributed to COVID-19. We used a multivariable logistic regression to evaluate independent associations between environmental and societal factors and death, after controlling for individual-level risk factors. We used a series of nested mixed-effects models to establish whether environmental and societal factors sufficiently explained country-level variations in death.\n\n14 044 patients from 23 countries were included in the analyses. 10 178 (72\u00b75%) individuals were female and 3866 (27\u00b75%) were male, with a mean age of 54\u00b74 years (SD 15\u00b76). Air pollution (odds ratio 1\u00b710 per 10 \u03bcg/m3 [95% CI 1\u00b701-1\u00b717]; p=0\u00b70105), proportion of the population aged 65 years or older (1\u00b719 per 1% increase [1\u00b710-1\u00b730]; p<0\u00b70001), and population mobility (1\u00b703 per 1% increase in number of visits to grocery and pharmacy stores [1\u00b702-1\u00b705]; p<0\u00b70001 and 1\u00b702 per 1% increase in number of visits to workplaces [1\u00b700-1\u00b703]; p=0\u00b7032) were independently associated with higher odds of mortality. Number of hospital beds (0\u00b794 per 1-unit increase per 1000 people [0\u00b788-1\u00b700]; p=0\u00b7046), human development index (0\u00b765 per 0\u00b71-unit increase [0\u00b744-0\u00b796]; p=0\u00b7032), government response stringency (0\u00b783 per 10-unit increase in containment index [0\u00b774-0\u00b793]; p=0\u00b70018), as well as follow-up time (0\u00b778 per month [0\u00b769-0\u00b788]; p<0\u00b70001) were independently associated with lower odds of mortality. These factors sufficiently explained country-level variations in death attributable to COVID-19 (intraclass correlation coefficient 1\u00b72% [0\u00b71-9\u00b75]; p=0\u00b714).\n\nOur findings highlight the importance of environmental and societal factors as potential explanations of the observed regional disparities in COVID-19 outcomes among people with rheumatic disease and lay foundation for a new research agenda to address these disparities.\n\nAmerican College of Rheumatology and European Alliance of Associations for Rheumatology.", "doi": "10.1016/S2665-9913(22)00192-8", "pmid": "35909441", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2665-9913(22)00192-8"}, {"db": "pmc", "key": "PMC9313519"}], "notes": [], "created": "2022-08-11T12:05:46.825Z", "modified": "2022-08-11T12:05:46.841Z"}, {"entity": "publication", "iuid": "1b953f2643e640a9ac8c200626ce9e13", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b953f2643e640a9ac8c200626ce9e13.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b953f2643e640a9ac8c200626ce9e13"}}, "title": "Substantial impact of mobility restrictions on reducing COVID-19 incidence in Italy in 2020.", "authors": [{"family": "Vinceti", "given": "Marco", "initials": "M", "orcid": "0000-0002-0551-2473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a25953d69dcd4b9bb597385be88340bc.json"}}, {"family": "Balboni", "given": "Erica", "initials": "E"}, {"family": "Rothman", "given": "Kenneth J", "initials": "KJ"}, {"family": "Teggi", "given": "Sergio", "initials": "S"}, {"family": "Bellino", "given": "Stefania", "initials": "S"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Ferrari", "given": "Fabrizio", "initials": "F"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}, {"family": "Filippini", "given": "Tommaso", "initials": "T"}], "type": "journal article", "published": "2022-07-24", "journal": {"title": "J Travel Med", "issn": "1708-8305", "issn-l": null}, "abstract": "Italy was the first country after China to be severely affected by the COVID-19 pandemic, in early 2020. The country responded swiftly to the outbreak with a nationwide two-step lockdown, the first one light, and the second one tight. By analysing 2020 national mobile phone movements, we assessed how lockdown compliance influenced its efficacy.\n\nWe measured individual mobility during the first epidemic wave with mobile phone movements tracked through carrier networks, and related this mobility to daily new SARS-CoV-2 infections, hospital admissions, intensive care admissions and deaths attributed to COVID-19, taking into account reason for travel (work-related or not) and the means of transport.\n\nThe tight lockdown resulted in an 82% reduction in mobility for the entire country and was effective in swiftly curbing the outbreak as indicated by a shorter time-to-peak of all health outcomes, particularly for provinces with the highest mobility reductions and the most intense COVID-19 spread. Reduction of work-related mobility was accompanied by a nearly linear benefit in outbreak containment; work-unrelated movements had a similar effect only for restrictions exceeding 50%. Reduction in mobility by car and by airplane was nearly linearly associated with a decrease in most COVID-19 health outcomes, while for train travel reductions exceeding 55% had no additional beneficial effects. The absence of viral variants and vaccine availability during the study period eliminated confounding from these two sources.\n\nAdherence to the COVID-19 tight lockdown during the first wave in Italy was high and effective in curtailing the outbreak. Any work-related mobility reduction was effective, but only high reductions in work-unrelated mobility restrictions were effective. For train travel, there was a threshold above which no further benefit occurred. These findings could be particular to the spread of SARS-CoV-2, but might also apply to other communicable infections with comparable transmission dynamics.", "doi": "10.1093/jtm/taac081", "pmid": "35876268", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6649390"}], "notes": [], "created": "2022-08-12T08:39:30.176Z", "modified": "2022-08-12T08:39:30.205Z"}, {"entity": "publication", "iuid": "f0fae26f35db4e589c037eedb07353a8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f0fae26f35db4e589c037eedb07353a8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f0fae26f35db4e589c037eedb07353a8"}}, "title": "COVID-19 Vaccination In Autoimmune Diseases (COVAD) Study: Vaccine Safety In Idiopathic Inflammatory Myopathies.", "authors": [{"family": "Gil-Vila", "given": "Albert", "initials": "A"}, {"family": "Naveen", "given": "R", "initials": "R"}, {"family": "Selva-O'Callaghan", "given": "Albert", "initials": "A"}, {"family": "Sen", "given": "Parikshit", "initials": "P"}, {"family": "Nune", "given": "Arvind", "initials": "A"}, {"family": "Gaur", "given": "Prithvi Sanjeevkumar", "initials": "PS"}, {"family": "Gonzalez", "given": "Raquel Ar\u00e0nega", "initials": "RA"}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Joshi", "given": "Mrudula", "initials": "M"}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V"}, {"family": "Kardes", "given": "Sinan", "initials": "S"}, {"family": "Kim", "given": "Minchul", "initials": "M"}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Makol", "given": "Ashima", "initials": "A"}, {"family": "Milchert", "given": "Marcin", "initials": "M"}, {"family": "Gheita", "given": "Tamer", "initials": "T"}, {"family": "Salim", "given": "Babur", "initials": "B"}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T"}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE"}, {"family": "Parodis", "given": "Ioannis", "initials": "I"}, {"family": "Nikiphorou", "given": "Elena", "initials": "E"}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL"}, {"family": "Chatterjee", "given": "Tulika", "initials": "T"}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L"}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA"}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK"}, {"family": "Ziade", "given": "Nelly", "initials": "N"}, {"family": "Knitza", "given": "Johannes", "initials": "J"}, {"family": "Kuwana", "given": "Masataka", "initials": "M"}, {"family": "Distler", "given": "Oliver", "initials": "O"}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V"}, {"family": "Aggarwal", "given": "Rohit", "initials": "R"}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "COVAD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-23", "journal": {"title": "Muscle Nerve", "issn": "1097-4598", "issn-l": null}, "abstract": "We studied COVID-19 vaccination-related adverse events (ADEs) 7-days post-vaccination in patients with idiopathic inflammatory myopathies (IIMs) and other systemic autoimmune and inflammatory disorders (SAIDs).\n\n7-day vaccine ADEs were collected in an international patient self-reported e-survey. Descriptive statistics and multivariable regression were performed.\n\n10,900 respondents [1227 IIMs; 4640 SAIDs; 5033 healthy controls (HCs), median age 42 (IQR 30-55) years, 74% female, 45% Caucasian, 69% completely vaccinated] were analysed. 76.3% IIMs patients reported minor and 4.6% major ADEs. Patients with active IIMs reported more frequent major [OR 2.7 (1.04-7.3)] and minor [OR 1.5 (1.1-2.2)] ADEs than inactive IIMs. Rashes were more frequent in IIMs [OR-2.3(1.2-4.2)] than HCs. ADEs were not impacted by steroid dose, although hydroxychloroquine and intravenous/subcutaneous immunoglobulins were associated with a higher risk of minor ADEs [OR 1.9 (1.1-3.3), OR 2.2 (1.1-4.3)]. Overall, ADEs were less frequent in inclusion body myositis (IBM) and BNT162b2 (Pfizer) vaccine recipients DISCUSSION: 7-day post-vaccination ADEs were comparable in patients with IIMs, SAIDs, and HCs, except for a higher risk of rashes in IIMs. Patients with DM, active disease may be at higher risk, and IBM patients at lower risk of specific ADEs. Overall, the benefit of preventing severe COVID-19 through vaccination likely outweighs the risk of vaccine-related ADEs Our results may inform future guidelines regarding COVID-19 vaccination in patients with SAIDs, and specifically in IIMs. Studies to evaluate long-term outcomes and disease flares are needed to shed more light on developing future COVID-19 vaccination guidelines. This article is protected by copyright. All rights reserved.", "doi": "10.1002/mus.27681", "pmid": "35869701", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9349921"}], "notes": [], "created": "2022-08-12T08:41:00.315Z", "modified": "2022-08-12T08:41:00.388Z"}, {"entity": "publication", "iuid": "4003a925eb2c466f8c22f00f2ea1dbfd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4003a925eb2c466f8c22f00f2ea1dbfd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4003a925eb2c466f8c22f00f2ea1dbfd"}}, "title": "Development of a Prediction Model for COVID-19 Acute Respiratory Distress Syndrome in Patients With Rheumatic Diseases: Results From the Global Rheumatology Alliance Registry.", "authors": [{"family": "Izadi", "given": "Zara", "initials": "Z", "orcid": "0000-0002-1867-0905", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea11c7b8c33a4535bd66a64954de7cd4.json"}}, {"family": "Gianfrancesco", "given": "Milena A", "initials": "MA", "orcid": "0000-0002-8351-4626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dca9cada1314065ab094be6fc17524e.json"}}, {"family": "Aguirre", "given": "Alfredo", "initials": "A", "orcid": "0000-0001-6999-6297", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b39f93f5d6aa452da23107f8608e5304.json"}}, {"family": "Strangfeld", "given": "Anja", "initials": "A"}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL"}, {"family": "Gossec", "given": "Laure", "initials": "L"}, {"family": "Carmona", "given": "Loreto", "initials": "L"}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S", "orcid": "0000-0002-8611-162X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73b17eb08d984421847f733b7a6a49d4.json"}}, {"family": "Kearsley-Fleet", "given": "Lianne", "initials": "L", "orcid": "0000-0003-0377-1575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9cc64aac266462baf67998b3d49c6f7.json"}}, {"family": "Schaefer", "given": "Martin", "initials": "M", "orcid": "0000-0001-6487-3634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb2c617a7902440eb574fcb1141785ac.json"}}, {"family": "Seet", "given": "Andrea M", "initials": "AM"}, {"family": "Schmajuk", "given": "Gabriela", "initials": "G", "orcid": "0000-0003-2687-5043", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9ea497446e44b87b2169bc6c67fbf38.json"}}, {"family": "Jacobsohn", "given": "Lindsay", "initials": "L"}, {"family": "Katz", "given": "Patricia", "initials": "P", "orcid": "0000-0002-8146-2519", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/142b667a5d2c4a6a87af7c4315130d3b.json"}}, {"family": "Rush", "given": "Stephanie", "initials": "S"}, {"family": "Al-Emadi", "given": "Samar", "initials": "S", "orcid": "0000-0001-7942-4831", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49a627d387d042f7b99d821d9676d0d5.json"}}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA", "orcid": "0000-0002-5556-4618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/192552e5e3d2435799e57111ea84502d.json"}}, {"family": "Hsu", "given": "Tiffany Y-T", "initials": "TY"}, {"family": "Patel", "given": "Naomi J", "initials": "NJ"}, {"family": "Wise", "given": "Leanna", "initials": "L", "orcid": "0000-0002-6172-9474", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a7e415e8715491bb9d0409d4b008443.json"}}, {"family": "Gilbert", "given": "Emily", "initials": "E"}, {"family": "Duarte-Garc\u00eda", "given": "Al\u00ed", "initials": "A", "orcid": "0000-0003-1749-5719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77a5555c1b624ba49ee7c729be2aef95.json"}}, {"family": "Valenzuela-Almada", "given": "Maria O", "initials": "MO"}, {"family": "Ugarte-Gil", "given": "Manuel F", "initials": "MF"}, {"family": "Ribeiro", "given": "Sandra L\u00facia Euz\u00e9bio", "initials": "SLE", "orcid": "0000-0002-4777-8659", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2db6a09138844b1690855b8b44af31ec.json"}}, {"family": "de Oliveira Marinho", "given": "Adriana", "initials": "A"}, {"family": "de Azevedo Valadares", "given": "Lilian David", "initials": "LD"}, {"family": "Giuseppe", "given": "Daniela Di", "initials": "DD"}, {"family": "Hasseli", "given": "Rebecca", "initials": "R"}, {"family": "Richter", "given": "Jutta G", "initials": "JG"}, {"family": "Pfeil", "given": "Alexander", "initials": "A", "orcid": "0000-0002-2709-6685", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a810753de5340c189b577ca7e5f5935.json"}}, {"family": "Schmeiser", "given": "Tim", "initials": "T"}, {"family": "Isnardi", "given": "Carolina A", "initials": "CA"}, {"family": "Reyes Torres", "given": "Alvaro A", "initials": "AA"}, {"family": "Alle", "given": "Gelsomina", "initials": "G"}, {"family": "Saurit", "given": "Ver\u00f3nica", "initials": "V"}, {"family": "Zanetti", "given": "Anna", "initials": "A"}, {"family": "Carrara", "given": "Greta", "initials": "G"}, {"family": "Labreuche", "given": "Julien", "initials": "J"}, {"family": "Barnetche", "given": "Thomas", "initials": "T"}, {"family": "Herasse", "given": "Muriel", "initials": "M"}, {"family": "Plassart", "given": "Samira", "initials": "S"}, {"family": "Santos", "given": "Maria Jos\u00e9", "initials": "MJ", "orcid": "0000-0002-7946-1365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d031d58f434247fd83359ee0c7602db5.json"}}, {"family": "Rodrigues", "given": "Ana Maria", "initials": "AM"}, {"family": "Robinson", "given": "Philip C", "initials": "PC", "orcid": "0000-0002-3156-3418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/950b622d31724172817ccde09902d215.json"}}, {"family": "Machado", "given": "Pedro M", "initials": "PM", "orcid": "0000-0002-8411-7972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef40d1eea57946e4a37d2e92a02a47cd.json"}}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS", "orcid": "0000-0003-0786-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d99dc166f48d4af7b8e46dc999c7444b.json"}}, {"family": "Sufka", "given": "Paul", "initials": "P"}, {"family": "Grainger", "given": "Rebecca", "initials": "R", "orcid": "0000-0001-9201-8678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9d304e9e29a43a5a7a76679c002a876.json"}}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Costello", "given": "Wendy", "initials": "W"}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Yazdany", "given": "Jinoos", "initials": "J", "orcid": "0000-0002-3508-4094", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62bbeb3392ce40d482da768af63f5d54.json"}}, {"family": "Global Rheumatology Alliance Registry", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-22", "journal": {"title": "ACR Open Rheumatol", "issn": "2578-5745", "issn-l": null}, "abstract": "Some patients with rheumatic diseases might be at higher risk for coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS). We aimed to develop a prediction model for COVID-19 ARDS in this population and to create a simple risk score calculator for use in clinical settings.\n\nData were derived from the COVID-19 Global Rheumatology Alliance Registry from March 24, 2020, to May 12, 2021. Seven machine learning classifiers were trained on ARDS outcomes using 83 variables obtained at COVID-19 diagnosis. Predictive performance was assessed in a US test set and was validated in patients from four countries with independent registries using area under the curve (AUC), accuracy, sensitivity, and specificity. A simple risk score calculator was developed using a regression model incorporating the most influential predictors from the best performing classifier.\n\nThe study included 8633 patients from 74 countries, of whom 523 (6%) had ARDS. Gradient boosting had the highest mean AUC (0.78; 95% confidence interval [CI]: 0.67-0.88) and was considered the top performing classifier. Ten predictors were identified as key risk factors and were included in a regression model. The regression model that predicted ARDS with 71% (95% CI: 61%-83%) sensitivity in the test set, and with sensitivities ranging from 61% to 80% in countries with independent registries, was used to develop the risk score calculator.\n\nWe were able to predict ARDS with good sensitivity using information readily available at COVID-19 diagnosis. The proposed risk score calculator has the potential to guide risk stratification for treatments, such as monoclonal antibodies, that have potential to reduce COVID-19 disease progression.", "doi": "10.1002/acr2.11481", "pmid": "35869686", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9350083"}], "notes": [], "created": "2022-08-12T08:41:21.838Z", "modified": "2022-08-12T08:41:22.412Z"}, {"entity": "publication", "iuid": "a1d27599cc614d1faeaa0ad9baf77bcf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a1d27599cc614d1faeaa0ad9baf77bcf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a1d27599cc614d1faeaa0ad9baf77bcf"}}, "title": "Nurses' Experiences of Caring for Patients With Suspected or Confirmed COVID-19 in the Initial Stage of the Pandemic.", "authors": [{"family": "Mattsson", "given": "Janet", "initials": "J"}, {"family": "Hedlund", "given": "Elin", "initials": "E"}, {"family": "George-Svahn", "given": "Lisa", "initials": "L"}, {"family": "Scheers-Andersson", "given": "Elina", "initials": "E"}, {"family": "Mazaheri", "given": "Monir", "initials": "M"}, {"family": "Bj\u00f6rling", "given": "Gunilla", "initials": "G", "orcid": "0000-0003-1445-900X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae42c961332e49a3aca05f09c4a70f27.json"}}], "type": "journal article", "published": "2022-07-21", "journal": {"title": "SAGE Open Nurs", "issn": "2377-9608", "volume": "8", "pages": "23779608221114981", "issn-l": null}, "abstract": "Nursing staff have faced various challenges during the global pandemic of COVID-19 such as nursing shortages. The great number of COVID-19 patients requiring hospitalization placed heavy demands on healthcare staff to maintain patient safety and to work according to constantly changing guidelines to prevent the spread of infection.\n\nThe objective was to describe nurses' experiences of caring for patients with suspected or confirmed COVID-19 in the initial phase of the pandemic.\n\nThe study has a qualitative design. Semi-structured interviews were conducted with seven nurses in primary care and hospital care during the initial stage of the pandemic. Qualitative content analysis with an inductive approach was used.\n\nThe nurses expressed that the working routines changed very quickly at the onset of the pandemic. A triage system was implemented to care for patients with symptoms of COVID-19 to prevent transmission between patients. A major change was the constant use of personal protective equipment in patient care. The nurses also experienced a sense of inadequacy regarding the care of the patients and became emotionally affected and exhausted.\n\nThe nurses experienced that many patients worsened clinically, leading to exhausting and difficult nursing care situations. They also experienced increasing responsibility since new protective equipment and procedures needed to be quickly implemented according to frequently changing recommendations, causing the nurses to feel uncertain about how to maintain patient safety. Support from colleagues was crucial to cope throughout the initial stage of the pandemic.", "doi": "10.1177/23779608221114981", "pmid": "35899037", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1177_23779608221114981"}, {"db": "pmc", "key": "PMC9310289"}], "notes": [], "created": "2022-08-12T08:33:56.133Z", "modified": "2022-08-12T08:33:56.186Z"}, {"entity": "publication", "iuid": "a011e37c6ff0437495b432ae29271bdf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a011e37c6ff0437495b432ae29271bdf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a011e37c6ff0437495b432ae29271bdf"}}, "title": "Correction to: Persisting Salivary IgG Against SARS-CoV-2 at 9 Months After Mild COVID-19: A Complementary Approach to Population Surveys.", "authors": [{"family": "Alkharaan", "given": "Hassan", "initials": "H"}, {"family": "Bayati", "given": "Shaghayegh", "initials": "S"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Olsson", "given": "Annika", "initials": "A"}, {"family": "Lindahl", "given": "Karin", "initials": "K"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "Tsilingaridis", "given": "Georgios", "initials": "G"}, {"family": "De Palma", "given": "Patricia", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M", "orcid": "0000-0002-3793-4064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4bc179656eb442f9ac9dc72c8c6841d.json"}}], "type": "published erratum", "published": "2022-07-21", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899"}, "abstract": null, "doi": "10.1093/infdis/jiac121", "pmid": "35859351", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "6647598"}], "notes": [], "created": "2022-08-12T08:42:51.642Z", "modified": "2022-08-12T08:43:07.903Z"}, {"entity": "publication", "iuid": "f1bc151cf7c44c80bb8c06fbbb08d26e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1bc151cf7c44c80bb8c06fbbb08d26e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1bc151cf7c44c80bb8c06fbbb08d26e"}}, "title": "Intrapulmonary Bronchopulmonary Anastomoses in Severe COVID-19-related Acute Respiratory Failure.", "authors": [{"family": "Bodmer", "given": "Jenna", "initials": "J", "orcid": "0000-0003-3110-6679", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4a89b7b5ac7474899be9ef2b0762306.json"}}, {"family": "Levin", "given": "Alice", "initials": "A"}, {"family": "West\u00f6\u00f6", "given": "Christian", "initials": "C"}, {"family": "van der Have", "given": "Oscar", "initials": "O", "orcid": "0000-0003-4726-0697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/120c66dfee0349df981dbe1dff391e8f.json"}}, {"family": "Peruzzi", "given": "Niccol\u00f2", "initials": "N"}, {"family": "Tran-Lundmark", "given": "Karin", "initials": "K"}, {"family": "Abman", "given": "Steven H", "initials": "SH", "orcid": "0000-0002-7292-2085", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/236683b5bd3f4cc6ad63453734a23185.json"}}, {"family": "Galambos", "given": "Csaba", "initials": "C"}], "type": "journal article", "published": "2022-07-20", "journal": {"title": "Am J Respir Crit Care Med", "issn": "1535-4970", "issn-l": "1073-449X"}, "abstract": null, "doi": "10.1164/rccm.202205-0922LE", "pmid": "35857856", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2022-08-12T08:46:06.359Z", "modified": "2022-08-12T08:46:36.162Z"}, {"entity": "publication", "iuid": "236664e051fe44f2a7a3daf4b7131667", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/236664e051fe44f2a7a3daf4b7131667.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/236664e051fe44f2a7a3daf4b7131667"}}, "title": "Compliance with Health Recommendations and Vaccine Hesitancy During the COVID Pandemic in Nine Countries.", "authors": [{"family": "Lansford", "given": "Jennifer E", "initials": "JE", "orcid": "0000-0003-1956-4917", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/099f957450e743acab538878cc487a27.json"}}, {"family": "Rothenberg", "given": "W Andrew", "initials": "WA"}, {"family": "Yotanyamaneewong", "given": "Saengduean", "initials": "S"}, {"family": "Alampay", "given": "Liane Pe\u00f1a", "initials": "LP"}, {"family": "Al-Hassan", "given": "Suha M", "initials": "SM"}, {"family": "Bacchini", "given": "Dario", "initials": "D"}, {"family": "Bornstein", "given": "Marc H", "initials": "MH"}, {"family": "Chang", "given": "Lei", "initials": "L"}, {"family": "Deater-Deckard", "given": "Kirby", "initials": "K"}, {"family": "Di Giunta", "given": "Laura", "initials": "L"}, {"family": "Dodge", "given": "Kenneth A", "initials": "KA"}, {"family": "Gurdal", "given": "Sevtap", "initials": "S"}, {"family": "Liu", "given": "Qin", "initials": "Q"}, {"family": "Long", "given": "Qian", "initials": "Q"}, {"family": "Morgenstern", "given": "Glen", "initials": "G"}, {"family": "Oburu", "given": "Paul", "initials": "P"}, {"family": "Pastorelli", "given": "Concetta", "initials": "C"}, {"family": "Skinner", "given": "Ann T", "initials": "AT"}, {"family": "Sorbring", "given": "Emma", "initials": "E"}, {"family": "Tapanya", "given": "Sombat", "initials": "S"}, {"family": "Steinberg", "given": "Laurence", "initials": "L"}, {"family": "Uribe Tirado", "given": "Liliana Maria", "initials": "LM"}], "type": "journal article", "published": "2022-07-20", "journal": {"title": "Prev Sci", "issn": "1573-6695", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Longitudinal data from the Parenting Across Cultures study of children, mothers, and fathers in 12 cultural groups in nine countries (China, Colombia, Italy, Jordan, Kenya, the Philippines, Sweden, Thailand, and the USA; N = 1331 families) were used to understand predictors of compliance with COVID-19 mitigation strategies and vaccine hesitancy. Confidence in government responses to the COVID pandemic was also examined as a potential moderator of links between pre-COVID risk factors and compliance with COVID mitigation strategies and vaccine hesitancy. Greater confidence in government responses to the COVID pandemic was associated with greater compliance with COVID mitigation strategies and less vaccine hesitancy across cultures and reporters. Pre-COVID financial strain and family stress were less consistent predictors of compliance with COVID mitigation strategies and vaccine hesitancy than confidence in government responses to the pandemic. Findings suggest the importance of bolstering confidence in government responses to future human ecosystem disruptions, perhaps through consistent, clear, non-partisan messaging and transparency in acknowledging limitations and admitting mistakes to inspire compliance with government and public health recommendations.", "doi": "10.1007/s11121-022-01399-9", "pmid": "35857257", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11121-022-01399-9"}], "notes": [], "created": "2022-08-12T08:46:57.085Z", "modified": "2022-08-12T08:47:32.154Z"}, {"entity": "publication", "iuid": "6dcf04f2676e49fcb47b08767d4c064a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6dcf04f2676e49fcb47b08767d4c064a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6dcf04f2676e49fcb47b08767d4c064a"}}, "title": "\"The New Educational Project TELEVASCULAR GAMES During COVID-19 Pandemic.\"", "authors": [{"family": "Chisci", "given": "Emiliano", "initials": "E"}, {"family": "Parlani", "given": "Gianbattista", "initials": "G"}, {"family": "Gatta", "given": "Emanuele", "initials": "E"}, {"family": "Isernia", "given": "Giacomo", "initials": "G"}, {"family": "de Donato", "given": "Gianmarco", "initials": "G"}, {"family": "Antonello", "given": "Michele", "initials": "M"}, {"family": "Simonte", "given": "Gioele", "initials": "G"}, {"family": "K\u00f6lbel", "given": "Tilo", "initials": "T"}, {"family": "Bertoglio", "given": "Luca", "initials": "L"}, {"family": "Yeung", "given": "Kak Khee", "initials": "KK"}, {"family": "Donas", "given": "Konstantinos", "initials": "K"}, {"family": "Fazzini", "given": "Stefano", "initials": "S"}, {"family": "Dias", "given": "Nuno", "initials": "N"}, {"family": "Michelagnoli", "given": "Stefano", "initials": "S"}, {"family": "Televascolare Games Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-20", "journal": {"title": "J Vasc Surg Cases Innov Tech", "issn": "2468-4287", "issn-l": null}, "abstract": "To report methodology and first-year results of a new educational project called \"Televascular Games\", which took place during COVID-19 pandemic.\n\nComplex aneurysmal aortic disease was discussed during a 2-hour competition webinar, according to three modalities. 1) Planning case competition (PCC): 2-4 pre-operative Computed Tomography Angiography (CTA) scans of an already performed selected case were submitted for the competition. CTA-scans were anonymously uploaded, without any reference to the center or the surgeon who performed the case. The competitor had to prepare a presentation of how he/she would have diagnosed, sized, planned, treated and followed up the case, of the medical therapy and of the bail-out maneuvers. 2) Challenging case competition (CCC): the competitor elaborates a presentation of an already treated case concerning an aortic topic and discusses sizing, planning, treatment, possible bail-out maneuvers and obtained results. For the CCC and PCC, the competitors with the best score were pre-selected to present and discuss their plan during the webinars. 3) Quiz competition (QZ): 2-6 angio-CTA scans of already performed selected aortic cases were submitted for the competition. A quiz with multiple-choice questions was answered by the competitors. The top four competitors were selected for the webinars and then they discussed the cases during the webinar. Finally, at the end of the case-discussion, the effective case resolution and follow-up were shown. A final winner was voted via televoting, based on six pre-established criteria. The project was endorsed by different National and International Societies.\n\nBetween October-2020 and December-2021, there were 12 Italian and 1 international webinars with overall 1695 participants (mean 130, range:86-177). Competitors were 54 (mean age 27, range 22-38 years). Two editions were CCCs, two QZs, and nine PCCs. The reliability of the inter-observer sizing of competitors was k=.43 and k=.62 for the proximal and distal sealing measurements respectively and very good (k =.88-.95) in the evaluation of orientation of the vessels, presence of angulations, calcifications and thrombus. The sizing discrepancy resulted in a significant variability of the planning (k=.45). The project ranked 9.6 in a \"10-point\" rating scale by all the participants and competitors.\n\nThe formula of gaming and collegial discussion of aortic cases herein reported has proved valid and attractive during COVID-19 pandemic period. The variability of the results on sizing and planning suggested to confer with a second opinion especially for less experienced surgeons.", "doi": "10.1016/j.jvscit.2022.05.019", "pmid": "35873717", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2468-4287(22)00109-5"}, {"db": "pmc", "key": "PMC9296369"}], "notes": [], "created": "2022-08-12T08:40:33.491Z", "modified": "2022-08-12T08:40:33.519Z"}, {"entity": "publication", "iuid": "5c00b8b46bf74290a4762e8d234a03c1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c00b8b46bf74290a4762e8d234a03c1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c00b8b46bf74290a4762e8d234a03c1"}}, "title": "Methodological guidance for incorporating equity when informing rapid-policy and guideline development.", "authors": [{"family": "Dewidar", "given": "Omar", "initials": "O"}, {"family": "Kawala", "given": "Brenda Allen", "initials": "BA"}, {"family": "Antequera", "given": "Alba", "initials": "A"}, {"family": "Tricco", "given": "Andrea C", "initials": "AC"}, {"family": "Tovey", "given": "David", "initials": "D"}, {"family": "Straus", "given": "Sharon", "initials": "S"}, {"family": "Glover", "given": "Rebecca", "initials": "R"}, {"family": "Tufte", "given": "Janice", "initials": "J"}, {"family": "Magwood", "given": "Olivia", "initials": "O"}, {"family": "Smith", "given": "Maureen", "initials": "M"}, {"family": "Ooi", "given": "Cheow Peng", "initials": "CP"}, {"family": "Dion", "given": "Anna", "initials": "A"}, {"family": "Goetghebeur", "given": "Mireille", "initials": "M"}, {"family": "Reveiz", "given": "Ludovic", "initials": "L"}, {"family": "Negrini", "given": "Stefano", "initials": "S"}, {"family": "Tugwell", "given": "Peter", "initials": "P"}, {"family": "Petkovic", "given": "Jennifer", "initials": "J"}, {"family": "Welch", "given": "Vivian", "initials": "V"}, {"family": "COVID-END Equity Task Force", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-19", "journal": {"title": "J Clin Epidemiol", "issn": "1878-5921", "issn-l": null, "volume": "150", "issue": null, "pages": "142-153"}, "abstract": "We provide guidance for considering equity in rapid reviews through examples of published COVID-19 rapid reviews.\r\n\r\nThis guidance was developed based on a series of methodological meetings, review of internationally renowned guidance such as the Cochrane Handbook and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis for equity-focused systematic reviews (PRISMA-Equity) guideline. We identified Exemplar rapid reviews by searching COVID-19 databases and requesting examples from our team.\r\n\r\nWe proposed the following key steps: 1. involve relevant stakeholders with lived experience in the conduct and design of the review; 2. reflect on equity, inclusion and privilege in team values and composition; 3. develop research question to assess health inequities; 4. conduct searches in relevant disciplinary databases; 5. collect data and critically appraise recruitment, retention and attrition for populations experiencing inequities; 6. analyse evidence on equity; 7. evaluate the applicability of findings to populations experiencing inequities; and 8. adhere to reporting guidelines for communicating review findings. We illustrated these methods through rapid review examples.\r\n\r\nImplementing this guidance could contribute to improving equity considerations in rapid reviews produced in public health emergencies, and help policymakers better understand the distributional impact of diseases on the population.", "doi": "10.1016/j.jclinepi.2022.07.007", "pmid": "35863618", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0895-4356(22)00180-9"}, {"db": "pmc", "key": "PMC9359903"}], "notes": [], "created": "2022-08-12T08:42:08.653Z", "modified": "2022-11-09T08:37:56.301Z"}, {"entity": "publication", "iuid": "1d5ba17b4bf44ac89c3e293f7263ad7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d5ba17b4bf44ac89c3e293f7263ad7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d5ba17b4bf44ac89c3e293f7263ad7a"}}, "title": "Mental health in individuals with self-reported psychiatric symptoms during the COVID-19 pandemic: Baseline data from a swedish longitudinal cohort study.", "authors": [{"family": "Rozental", "given": "Alexander", "initials": "A"}, {"family": "S\u00f6rman", "given": "Karolina", "initials": "K"}, {"family": "Ojala", "given": "Olivia", "initials": "O"}, {"family": "Jangard", "given": "Simon", "initials": "S"}, {"family": "El Alaoui", "given": "Samir", "initials": "S"}, {"family": "M\u00e5nsson", "given": "Kristoffer N T", "initials": "KNT"}, {"family": "Shahnavaz", "given": "Shervin", "initials": "S"}, {"family": "Lundin", "given": "Johan", "initials": "J"}, {"family": "Forsstr\u00f6m", "given": "David", "initials": "D"}, {"family": "Hedman-Lagerl\u00f6f", "given": "Maria", "initials": "M"}, {"family": "Lundgren", "given": "Tobias", "initials": "T"}, {"family": "Jayaram-Lindstr\u00f6m", "given": "Nitya", "initials": "N"}], "type": "journal article", "published": "2022-07-19", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "13", "pages": "933858", "issn-l": "1664-0640"}, "abstract": "Individuals with psychiatric disorders may be both vulnerable and sensitive to rapid societal changes that have occurred during the COVID-19 pandemic. To fully understand these impacts, repeated measurements of these individuals are warranted. The current longitudinal study set out to perform monthly assessment of individuals with common psychiatric disorders using established questionnaires with a possibility for them to self- rate their symptoms, over time.\n\nRecruitment of individuals who identified themselves as struggling with mental health problems, living in Sweden between July 2020 and June 2021 using an online survey. The individuals answered questions on demographics, psychiatric history, current psychiatric symptoms (e.g., Patient Health Questionnaire, PHQ-9; General Anxiety Disorder, GAD-7), somatic health, health-care contacts and any changes therein during the pandemic. Monthly, longitudinal assessments are still ongoing (consenting participants provide data for 1 year), and here we present descriptive statistics from the baseline measurement. All measurements from baseline (>400 items), and follow-ups are presented in detail.\n\nA total of 6.095 participants (average age 35 years) submitted complete baseline data. Marital status (43% single) and number of years of education (48% highest degree being high school) were evenly distributed in this population. The most common lifetime psychiatric disorder in the sample was depressive disorder (80.5%) and generalized anxiety disorder (45.9%), with a substantial proportion having severe symptoms of depression. (30.5%) and anxiety (37.1%). Lifetime suicidal ideation (75.0%) and non-suicidal self-harm (57.7%) were prevalent in the group and 14.5% reported drug use during the pandemic. Allergies (36.8%) were the most common somatic condition, followed by irritable bowel syndrome (18.7%). For those having experienced a traumatic event, 39% showed symptoms during the pandemic indicating PTSD. Regarding contact with mental health services during the pandemic, 22% had established a new contact, and 20% reported to have increased their psychiatric medication compared to before the pandemic.\n\nBaseline data collected during the pandemic from individuals in Sweden with pre-existing psychiatric disorders demonstrate that this sample represents a population suitable for an investigation on the long-term impact of the pandemic, as intended by the longitudinal investigation that is ongoing. Follow-up questionnaires over a 12-month period are being collected and will indicate how the health and well-being of this population was impacted during the changes and uncertainties that have been characteristic of the past 2 years.", "doi": "10.3389/fpsyt.2022.933858", "pmid": "35928773", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9343700"}], "notes": [], "created": "2022-08-11T11:59:59.748Z", "modified": "2022-08-11T11:59:59.764Z"}, {"entity": "publication", "iuid": "810ac4db03734d8891c68503f07daaf2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/810ac4db03734d8891c68503f07daaf2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/810ac4db03734d8891c68503f07daaf2"}}, "title": "Abrupt decreases in infectivity of SARS-CoV-2 in aerosols.", "authors": [{"family": "L\u00f6ndahl", "given": "Jakob", "initials": "J", "orcid": "0000-0001-9379-592X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7648041474a8469aa54218ca177e4c19.json"}}, {"family": "Alsved", "given": "Malin", "initials": "M"}], "type": "journal article", "published": "2022-07-19", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "119", "issue": "29", "pages": "e2208742119", "issn-l": "0027-8424"}, "abstract": null, "doi": "10.1073/pnas.2208742119", "pmid": "35858364", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9304013"}], "notes": [], "created": "2022-08-12T08:45:44.880Z", "modified": "2022-08-12T08:45:44.931Z"}, {"entity": "publication", "iuid": "733f8a5c26e7460db9284901482c7bd9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/733f8a5c26e7460db9284901482c7bd9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/733f8a5c26e7460db9284901482c7bd9"}}, "title": "The effect of herd immunity thresholds on willingness to vaccinate.", "authors": [{"family": "Andersson", "given": "Per A", "initials": "PA", "orcid": "0000-0001-7445-2008", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1fa117de5f540b7a5f13f97803c46b3.json"}}, {"family": "Tingh\u00f6g", "given": "Gustav", "initials": "G", "orcid": "0000-0002-8159-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c4dcebfe7b0425182298cf35259223c.json"}}, {"family": "V\u00e4stfj\u00e4ll", "given": "Daniel", "initials": "D", "orcid": "0000-0003-2873-4500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebf69c8715ab4141a7b06a20d94ca666.json"}}], "type": "journal article", "published": "2022-07-18", "journal": {"title": "Humanit Soc Sci Commun", "issn": "2662-9992", "volume": "9", "issue": "1", "pages": "243", "issn-l": null}, "abstract": "Throughout the COVID-19 pandemic, media and policymakers openly speculated about the number of immune citizens needed to reach a herd immunity threshold. What are the effects of such numerical goals on the willingness to vaccinate? In a large representative sample (N = 1540) of unvaccinated Swedish citizens, we find that giving a low (60%) compared to a high (90%) threshold has direct effects on beliefs about reaching herd immunity and beliefs about how many others that will get vaccinated. Presenting the high threshold makes people believe that herd immunity is harder to reach (on average about half a step on a seven-point scale), compared to the low threshold. Yet at the same time, people also believe that a higher number of the population will get vaccinated (on average about 3.3% more of the population). Since these beliefs affect willingness to vaccinate in opposite directions, some individuals are encouraged and others discouraged depending on the threshold presented. Specifically, in mediation analysis, the high threshold indirectly increases vaccination willingness through the belief that many others will get vaccinated (B = 0.027, p = 0.003). At the same time, the high threshold also decreases vaccination willingness through the belief that the threshold goal is less attainable (B = -0.053, p < 0.001) compared to the low threshold condition. This has consequences for ongoing COVID-19 vaccination and future vaccination campaigns. One message may not fit all, as different groups can be encouraged or discouraged from vaccination.", "doi": "10.1057/s41599-022-01257-7", "pmid": "35874284", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "1257"}, {"db": "pmc", "key": "PMC9294790"}], "notes": [], "created": "2022-08-12T08:40:09.826Z", "modified": "2022-08-12T08:40:09.921Z"}, {"entity": "publication", "iuid": "d7be028906b54732b7f52b626b93497c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d7be028906b54732b7f52b626b93497c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d7be028906b54732b7f52b626b93497c"}}, "title": "Following a healthy/balanced diet predicts lower anxiety and depression during the COVID-19 pandemic.", "authors": [{"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Fortea", "given": "Lydia", "initials": "L"}, {"family": "Pomarol-Clotet", "given": "Edith", "initials": "E"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Fullana", "given": "Miquel \u00c0ngel", "initials": "M\u00c0"}, {"family": "Solanes", "given": "Aleix", "initials": "A"}], "type": "case reports", "published": "2022-07-16", "journal": {"title": "Rev Psiquiatr Salud Ment (Engl Ed)", "issn": "2173-5050", "volume": "15", "issue": "2", "pages": "147-149", "issn-l": null}, "abstract": null, "doi": "10.1016/j.rpsmen.2022.07.003", "pmid": "35840282", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2173-5050(22)00027-9"}, {"db": "pmc", "key": "PMC9274263"}], "notes": [], "created": "2022-08-12T08:55:27.745Z", "modified": "2022-08-12T08:55:27.771Z"}, {"entity": "publication", "iuid": "2679a2dabc50490c856836088dddbab2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2679a2dabc50490c856836088dddbab2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2679a2dabc50490c856836088dddbab2"}}, "title": "Updated SIOG COVID-19 working group recommendations on COVID-19 vaccination among older adults with cancer.", "authors": [{"family": "Soto-Perez-de-Celis", "given": "Enrique", "initials": "E"}, {"family": "Mislang", "given": "Anna Rachelle", "initials": "AR"}, {"family": "Hern\u00e1ndez-Favela", "given": "Celia Gabriela", "initials": "CG"}, {"family": "Russo", "given": "Chiara", "initials": "C"}, {"family": "Colloca", "given": "Giuseppe", "initials": "G"}, {"family": "Williams", "given": "Grant R", "initials": "GR"}, {"family": "O'Hanlon", "given": "Shane", "initials": "S"}, {"family": "Cooper", "given": "Lisa", "initials": "L"}, {"family": "O'Donovan", "given": "Anita", "initials": "A"}, {"family": "Audisio", "given": "Riccardo A", "initials": "RA"}, {"family": "Cheung", "given": "Kwok-Leung", "initials": "KL"}, {"family": "Giron\u00e9s-Sarri\u00f3", "given": "Regina", "initials": "R"}, {"family": "Stauder", "given": "Reinhard", "initials": "R"}, {"family": "Jaklitsch", "given": "Michael", "initials": "M"}, {"family": "Cairo", "given": "Clarito", "initials": "C"}, {"family": "Gil", "given": "Luiz Antonio", "initials": "LA"}, {"family": "Alam", "given": "Mahmood", "initials": "M"}, {"family": "Sattar", "given": "Schroder", "initials": "S"}, {"family": "Kantilal", "given": "Kumud", "initials": "K"}, {"family": "Loh", "given": "Kah Poh", "initials": "KP"}, {"family": "Lichtman", "given": "Stuart M", "initials": "SM"}, {"family": "Brain", "given": "Etienne", "initials": "E"}, {"family": "Wildiers", "given": "Hans", "initials": "H"}, {"family": "Kanesvaran", "given": "Ravindran", "initials": "R"}, {"family": "Battisti", "given": "Nicol\u00f2 Matteo Luca", "initials": "NML"}], "type": "journal article", "published": "2022-07-15", "journal": {"title": "J Geriatr Oncol", "issn": "1879-4076", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jgo.2022.07.005", "pmid": "35853816", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1879-4068(22)00171-0"}, {"db": "pmc", "key": "PMC9283597"}], "notes": [], "created": "2022-08-12T08:49:28.874Z", "modified": "2022-08-12T08:49:28.879Z"}, {"entity": "publication", "iuid": "af44170e42fc454098218a59502ac0ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/af44170e42fc454098218a59502ac0ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/af44170e42fc454098218a59502ac0ef"}}, "title": "Oral manifestations in young adults infected with COVID-19 and impact of smoking: a multi-country cross-sectional study.", "authors": [{"family": "El Tantawi", "given": "Maha", "initials": "M", "orcid": "0000-0003-4989-6584", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b0b3508a71b54068bbfd0a3362541960.json"}}, {"family": "Sabbagh", "given": "Heba Jafar", "initials": "HJ"}, {"family": "Alkhateeb", "given": "Nada Abubakor", "initials": "NA"}, {"family": "Quritum", "given": "Maryam", "initials": "M"}, {"family": "Abourdan", "given": "Joud", "initials": "J"}, {"family": "Qureshi", "given": "Nafeesa", "initials": "N"}, {"family": "Qureshi", "given": "Shabnum", "initials": "S"}, {"family": "Hamoud", "given": "Ahmed", "initials": "A"}, {"family": "Mahmoud", "given": "Nada", "initials": "N"}, {"family": "Odeh", "given": "Ruba", "initials": "R"}, {"family": "Al-Khanati", "given": "Nuraldeen Maher", "initials": "NM"}, {"family": "Jaber", "given": "Rawiah", "initials": "R"}, {"family": "Balkhoyor", "given": "Abdulrahman Loaie", "initials": "AL"}, {"family": "Shabi", "given": "Mohammed", "initials": "M"}, {"family": "Folayan", "given": "Morenike O", "initials": "MO", "orcid": "0000-0002-9008-7730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f05ff9524108435d8c181463693f988e.json"}}, {"family": "Gomaa", "given": "Noha", "initials": "N"}, {"family": "Al Nahdi", "given": "Raqiya", "initials": "R"}, {"family": "Mahmoud", "given": "Nawal", "initials": "N"}, {"family": "El Wazziki", "given": "Hanane", "initials": "H"}, {"family": "Alnaas", "given": "Manal", "initials": "M"}, {"family": "Samodien", "given": "Bahia", "initials": "B"}, {"family": "Mahmoud", "given": "Rawa", "initials": "R"}, {"family": "Abu Assab", "given": "Nour", "initials": "N"}, {"family": "Saad", "given": "Sherin", "initials": "S"}, {"family": "Al-Hachim", "given": "Sondos", "initials": "S"}, {"family": "Alshaikh", "given": "Ali", "initials": "A"}, {"family": "Abdelaziz", "given": "Wafaa", "initials": "W"}], "type": "journal article", "published": "2022-07-15", "journal": {"title": "PeerJ", "issn": "2167-8359", "volume": "10", "pages": "e13555", "issn-l": "2167-8359"}, "abstract": "Oral manifestations and lesions could adversely impact the quality of people's lives. COVID-19 infection may interact with smoking and the impact on oral manifestations is yet to be discovered.\n\nThe aim of this study was to assess the self-reported presence of oral lesions by COVID-19-infected young adults and the differences in the association between oral lesions and COVID-19 infection in smokers and non-smokers.\n\nThis cross-sectional multi-country study recruited 18-to-23-year-old adults. A validated questionnaire was used to collect data on COVID-19-infection status, smoking and the presence of oral lesions (dry mouth, change in taste, and others) using an online platform. Multi-level logistic regression was used to assess the associations between the oral lesions and COVID-19 infection; the modifying effect of smoking on the associations.\n\nData was available from 5,342 respondents from 43 countries. Of these, 8.1% reported COVID-19-infection, 42.7% had oral manifestations and 12.3% were smokers. A significantly greater percentage of participants with COVID-19-infection reported dry mouth and change in taste than non-infected participants. Dry mouth (AOR=, 9=xxx) and changed taste (AOR=, 9=xxx) were associated with COVID-19- infection. The association between COVID-19-infection and dry mouth was stronger among smokers than non-smokers (AOR = 1.26 and 1.03, p = 0.09) while the association with change in taste was stronger among non-smokers (AOR = 1.22 and 1.13, p = 0.86).\n\nDry mouth and changed taste may be used as an indicator for COVID-19 infection in low COVID-19-testing environments. Smoking may modify the association between some oral lesions and COVID-19-infection.", "doi": "10.7717/peerj.13555", "pmid": "35860046", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "13555"}, {"db": "pmc", "key": "PMC9291069"}], "notes": [], "created": "2022-08-12T08:42:26.739Z", "modified": "2022-08-12T08:42:26.838Z"}, {"entity": "publication", "iuid": "0d9ee7903d15472dba9fe4a6d94c737d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d9ee7903d15472dba9fe4a6d94c737d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d9ee7903d15472dba9fe4a6d94c737d"}}, "title": "Immigrant background and socioeconomic status are associated with severe COVID-19 requiring intensive care.", "authors": [{"family": "Nordberg", "given": "Per", "initials": "P"}, {"family": "Jonsson", "given": "Martin", "initials": "M"}, {"family": "Hollenberg", "given": "Jacob", "initials": "J"}, {"family": "Ringh", "given": "Mattias", "initials": "M"}, {"family": "Kiiski Berggren", "given": "Ritva", "initials": "R"}, {"family": "Hofmann", "given": "Robin", "initials": "R"}, {"family": "Svensson", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2022-07-15", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "12133", "issn-l": "2045-2322"}, "abstract": "To determine whether immigrant background and socioeconomic status were associated with increased risk to develop severe Coronavirus disease 2019 (COVID-19) requiring mechanical ventilation at the intensive care unit and to study their effects on 90-day mortality. Nationwide case-control study with personal-level data from the Swedish Intensive Care register linked with socioeconomic data from Statistics Sweden and comorbidity data from the national patient register. For each case of COVID-19 treated with mechanical ventilation at the intensive care unit (outcome), 10 population controls were matched for age, sex and area of residence. Logistic and Cox regression were used to study the association between the exposure (immigrant background, income and educational level) and 90-day mortality. In total, 4 921 cases and 49 210 controls were matched. In the adjusted model, the risk of severe COVID-19 was highest in individuals born in Asia (Odds ratio [OR] = 2.44, 95% confidence interval [CI] = 2.20-2.69), South America (OR = 2.34, 95% CI = 1.82-2.98) and Africa (OR = 2.11, 95% CI = 1.76-2.50). Post-secondary education was associated with a lower risk of severe COVID-19 (OR = 0.75, CI = 0.69-0.82) as was the highest (vs. lowest) income quintile (OR = 0.87, CI = 0.77-0.97). In the fully adjusted Cox-regression analysis birth region of Africa (OR 1.38, CI = 1.03-1.86) and high income (OR 0.75, CI 0.63-0.89) were associated with 90-day mortality. Immigrant background, educational level and income were independently associated with acquiring severe COVID-19 with need for mechanical ventilation.", "doi": "10.1038/s41598-022-15884-2", "pmid": "35840691", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-15884-2"}, {"db": "pmc", "key": "PMC9285186"}], "notes": [], "created": "2022-08-12T08:55:10.836Z", "modified": "2022-08-12T08:55:10.842Z"}, {"entity": "publication", "iuid": "dda4e2f7fa5a492b99c23d4aa742a141", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dda4e2f7fa5a492b99c23d4aa742a141.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dda4e2f7fa5a492b99c23d4aa742a141"}}, "title": "Correction: Evaluation of science advice during the COVID-19 pandemic in Sweden.", "authors": [{"family": "Brusselaers", "given": "Nele", "initials": "N", "orcid": "0000-0003-0137-447X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8a4e9c84a5843c18e95fe0becb19506.json"}}, {"family": "Steadson", "given": "David", "initials": "D", "orcid": "0000-0003-3063-3880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce74e24664974b86943dcc03ba277cd4.json"}}, {"family": "Bjorklund", "given": "Kelly", "initials": "K"}, {"family": "Breland", "given": "Sofia", "initials": "S"}, {"family": "Stilhoff S\u00f6rensen", "given": "Jens", "initials": "J"}, {"family": "Ewing", "given": "Andrew", "initials": "A"}, {"family": "Bergmann", "given": "Sigurd", "initials": "S"}, {"family": "Steineck", "given": "Gunnar", "initials": "G"}], "type": "published erratum", "published": "2022-07-15", "journal": {"title": "Humanit Soc Sci Commun", "issn": "2662-9992", "volume": "9", "issue": "1", "pages": "239", "issn-l": null}, "abstract": "[This corrects the article DOI: 10.1057/s41599-022-01097-5.].", "doi": "10.1057/s41599-022-01254-w", "pmid": "35856700", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "1254"}, {"db": "pmc", "key": "PMC9284503"}], "notes": [], "created": "2022-08-12T08:47:40.670Z", "modified": "2022-08-12T08:47:50.453Z"}, {"entity": "publication", "iuid": "a8ba104875974e309f4d9950c3d67514", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8ba104875974e309f4d9950c3d67514.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8ba104875974e309f4d9950c3d67514"}}, "title": "Cognitive Behavioral Therapy and Acceptance and Commitment Therapy (CBT-ACT) vs. Standard Care After Critical Illness Due to COVID-19: Protocol for a Pilot Randomized Controlled Trial.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Lidin-Darlington", "given": "Pernilla", "initials": "P"}, {"family": "Lilja", "given": "Gisela", "initials": "G"}, {"family": "Nilsson", "given": "Anna", "initials": "A"}, {"family": "Schandl", "given": "Anna", "initials": "A"}, {"family": "Friberg", "given": "Hans", "initials": "H"}], "type": "journal article", "published": "2022-07-15", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "13", "pages": "907215", "issn-l": "1664-0640"}, "abstract": "Post-covid syndrome is an emerging condition involving a wide range of symptoms, including high rates of poor mental health. The diagnostic relevance and clinical severity of these symptoms are largely unknown, and evidence for treatment of post-covid mental health symptoms is lacking. This protocol describes a pilot randomized clinical trial, primarily aiming to assess feasibility, participant adherence and satisfaction in a novel phycho-therapeutic intervention on post-covid anxiety and depression symptoms \u22651 year after critically ill COVID-19. Whether the intervention may generate improvements in post-covid depression, anxiety, post-traumatic stress and health-related quality of life (HRQoL) will be addressed in a following larger trial.\n\nA multicenter, investigator-initiated randomized controlled trial (Clinical Trial Identifier number NCT05119608) including Intensive Care Unit (ICU)-treated COVID-19 survivors, who display symptoms of anxiety and/or depression at follow-up 12 months after hospitalization (Hospital Anxiety and Depression Scale \u22658 for depression or anxiety). Eligible individuals are referred to a psychiatrist for structured diagnostic assessment and inclusion in the trial. Participants will be randomized to either a 10-week cognitive behavioral therapy intervention with added acceptance and commitment therapy (CBT-ACT) or standard care (primary care referral). Primary study outcome measure is feasibility and patient adherence, defined as the proportion of participants who consent to randomization and remain in the study including follow-up. Secondary outcome measures include reduced symptoms in the HADS depression/anxiety subscales, post-traumatic symptoms, HRQoL and user satisfaction at 3 months after the intervention.\n\nThis protocol describes a pilot trial to assess feasibility and preliminary effects of a structured psycho-therapeutic intervention to ameliorate mental health in a population severely affected by COVID-19, where evidence for structured psycho-therapy is lacking.", "doi": "10.3389/fpsyt.2022.907215", "pmid": "35911237", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9334556"}], "notes": [], "created": "2022-08-11T12:04:49.893Z", "modified": "2022-08-11T12:04:49.909Z"}, {"entity": "publication", "iuid": "492bb62d87bc4d089a0e222326142c51", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/492bb62d87bc4d089a0e222326142c51.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/492bb62d87bc4d089a0e222326142c51"}}, "title": "Changes in food-related costs during the COVID-19 pandemic among families managing food allergy.", "authors": [{"family": "Golding", "given": "Michael A", "initials": "MA"}, {"family": "Lemoine-Courcelles", "given": "Cath\u00e9rine", "initials": "C"}, {"family": "Abrams", "given": "Elissa M", "initials": "EM"}, {"family": "Ben-Shoshan", "given": "Moshe", "initials": "M"}, {"family": "B\u00e9gin", "given": "Philippe", "initials": "P"}, {"family": "Chan", "given": "Edmond S", "initials": "ES"}, {"family": "Chu", "given": "Derek K", "initials": "DK"}, {"family": "Gerdts", "given": "Jennifer D", "initials": "JD"}, {"family": "Povolo", "given": "Beatrice", "initials": "B"}, {"family": "Kim", "given": "Harold", "initials": "H"}, {"family": "Simons", "given": "Elinor", "initials": "E"}, {"family": "Upton", "given": "Julia", "initials": "J"}, {"family": "Protudjer", "given": "Jennifer L P", "initials": "JLP"}], "type": "journal article", "published": "2022-07-15", "journal": {"title": "Front Allergy", "issn": "2673-6101", "volume": "3", "pages": "915014", "issn-l": null}, "abstract": "The COVID-19 pandemic has affected the supply, cost, and demand for certain foods, but it is not clear how these changes have affected food-allergic households.\n\nTo describe the changes in food-related costs that have followed COVID-19, as reported by higher- and lower-income households with a food-allergic member.\n\nBetween May 1-June 30, 2020, Canadian households, with at least one food-allergic member, completed an online survey on food shopping and preparation habits before and during the COVID-19 pandemic. The sample was divided into binary groups, either higher or lower than the sample median income. Data were analyzed using descriptive statistics and multiple regression.\n\nThe sample was comprised of 102 participants (i.e., 51/ income group). The three most common food allergies amongst both groups were peanuts, tree nuts and milk. Since the start of the pandemic, both groups reported greater monthly direct grocery costs, although costs amongst the higher-income group were twice as high as the lower-income group ($212.86 vs. $98.89, respectively). Indirect food preparation costs were similarly elevated. Higher-income households with food procurement difficulties reported increased indirect shopping costs following the outbreak of COVID-19, whereas those without such difficulties reported decreased costs. Lower-income households with allergies to milk, wheat, or eggs (i.e., staple allergy) experienced a larger change in indirect food preparation costs following the outbreak of COVID-19 relative to those with other food allergies ($244.58 vs. -$20.28, respectively; p = 0.03).\n\nBoth higher and lower income households with food allergy reported greater direct food costs and indirect food preparation costs following the COVID-19. Households with staple allergy and those with difficulties finding their typical food items were particularly affected.", "doi": "10.3389/falgy.2022.915014", "pmid": "35910861", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9334569"}], "notes": [], "created": "2022-08-11T12:05:21.065Z", "modified": "2022-08-11T12:05:21.099Z"}, {"entity": "publication", "iuid": "c7807ad156c64452a058896d3a6ab36b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7807ad156c64452a058896d3a6ab36b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7807ad156c64452a058896d3a6ab36b"}}, "title": "Protective effects of statins on COVID-19 risk, severity and fatal outcome: a nationwide Swedish cohort study.", "authors": [{"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Franz\u00e9n", "given": "Stefan", "initials": "S"}, {"family": "N\u00e5tman", "given": "Jonatan", "initials": "J"}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Parmryd", "given": "Ingela", "initials": "I"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2022-07-14", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "12047", "issn-l": "2045-2322"}, "abstract": "The impact of statins on COVID-19 remains unclear. This study aims to investigate whether statin exposure assessed both in the population and in well-defined cohorts of COVID-19 patients may affect the risk and severity of COVID-19 using nationwide Swedish population-based register data. A population \u2265 40 years was selected by age/sex-stratified random sampling from the Swedish population on 1 Jan 2020. COVID-19 outcomes were identified from the SmiNet database, the National Patient Register and/or Cause-of-Death Register and linked with the National Prescribed Drug Register and sociodemographic registers. Statin exposure was defined as any statin prescriptions in the year before index date. In Cox regressions, confounding was addressed using propensity score ATT (Average Treatment effect in the Treated) weighting. Of 572,695 individuals in the overall cohort, 22.3% had prior statin treatment. After ATT weighting, protective effects were observed among statin user for hospitalization and COVID-19 death in the overall cohort and onset cohort. In the hospitalized cohort, statin use was only associated with lower risk for death (HR = 0.86, 95% CI 0.79-0.95), but not ICU admission. Statin-treated individuals appear to have lower COVID-19 mortality than nonusers, whether assessed in the general population, from COVID-19 onset or from hospitalization.", "doi": "10.1038/s41598-022-16357-2", "pmid": "35835835", "labels": {"Topics: Register-based research": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-16357-2"}, {"db": "pmc", "key": "PMC9282150"}], "notes": [], "created": "2022-08-12T09:01:17.228Z", "modified": "2022-08-12T09:02:19.709Z"}, {"entity": "publication", "iuid": "f6f8942eecdf4d63ad6c37b4691d8742", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6f8942eecdf4d63ad6c37b4691d8742.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6f8942eecdf4d63ad6c37b4691d8742"}}, "title": "Work-Life Enrichment and Interference Among Swedish Workers: Trends From 2016 Until the COVID-19 Pandemic.", "authors": [{"family": "Brulin", "given": "Emma", "initials": "E"}, {"family": "Leineweber", "given": "Constanze", "initials": "C"}, {"family": "Peristera", "given": "Paraskevi", "initials": "P"}], "type": "journal article", "published": "2022-07-13", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "13", "pages": "854119", "issn-l": "1664-1078"}, "abstract": "The COVID-19 pandemic has altered workers' possibilities to combine work and private life. Work and private life could either interfere with each other, that is, when conflicting demands arise, or enrich, that is, when the two roles are beneficial to one another. Analyzing data from the Swedish Longitudinal Occupational Survey of Health through individual growth models, we investigated time trends of interference and enrichment between work and private life from 2016 through March to September 2020, which is during the first wave of the pandemic. The sample included workers who had remained in the same workplace throughout the study period and worked at least 30% of full time, reaching 5,465 individuals. In addition, we examined trends in level of interference and enrichment across gender and industries. Results showed that Life-to-work interference increased over time in the Swedish working population, but neither did work-to-life interference nor enrichment. We observed only marginal differences across gender. Also, in the industries of fine manufacturing and real-estate activities, a decrease in interference, work-to-life interference, and life-to-work interference, respectively, was observed. In the human health and social care industry, an increase in interference and life-to-work interference was seen. Our conclusion is that overall changes to the possibilities to balance work and private life have occurred for workers in Sweden during the first period of the pandemic. Further studies are needed to study development time trends throughout the pandemic and across different occupations.", "doi": "10.3389/fpsyg.2022.854119", "pmid": "35910960", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9328076"}], "notes": [], "created": "2022-08-11T12:05:05.016Z", "modified": "2022-08-11T12:05:05.022Z"}, {"entity": "publication", "iuid": "b396337b473149e2918bc8cd12aeffaf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b396337b473149e2918bc8cd12aeffaf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b396337b473149e2918bc8cd12aeffaf"}}, "title": "Effectiveness of a fourth dose of mRNA COVID-19 vaccine against all-cause mortality in long-term care facility residents and in the oldest old: A nationwide, retrospective cohort study in Sweden.", "authors": [{"family": "Nordstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Ballin", "given": "Marcel", "initials": "M"}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-07-13", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "pages": "100466", "issn-l": null}, "abstract": "The effect of a fourth dose of COVID-19 vaccine on the risk of death in the oldest and frailest individuals is unknown.\n\nTwo matched cohorts were formed using Swedish nationwide registers. In the first, residents of long-term care facilities (LTCFs) given a fourth dose of an mRNA vaccine from 1 January 2022 onwards were matched 1:1 on birth year and county of residence to residents given at least a third dose (N = 24,524). In the second, all individuals aged \u226580 years given a fourth dose were matched 1:1 to individuals given at least a third dose (N = 394,104). Cox regression models were used to estimate hazard ratios for all-cause mortality in fourth-dose recipients as compared with in third-dose recipients, with relative vaccine effectiveness (VE) estimated as 1 minus the hazard ratio.\n\nFrom 7 days after baseline and onwards, there were 1119 deaths in the LTCF cohort during a median follow-up of 77 days and a maximum follow-up of 126 days. During days 7 to 60, the VE of the fourth dose was 39% (95% CI, 29-48), which declined to 27% (95% CI, -2-48) during days 61 to 126. In the cohort of all individuals aged \u226580 years, there were 5753 deaths during a median follow-up of 73 days and a maximum follow-up of 143 days. During days 7 to 60, the VE of the fourth dose was 71% (95% CI, 69-72), which declined to 54% (95% CI, 48-60) during days 61 to 143. The VE of the fourth dose seemed stronger when it was compared to third-dose recipients where at least four months had passed since vaccination (P < 0\u00b7001 for interaction).\n\nAs compared with a third dose, a fourth dose of an mRNA COVID-19 vaccine, administered during the Omicron era, was associated with reduced risk of death from all causes in residents of LTCFs and in the oldest old during the first two months, after which the protection became slightly lower. These findings suggest that a fourth dose may prevent premature mortality in the oldest and frailest even after the emergence of the Omicron variant, although the timing of vaccination seems to be important with respect to the slight waning observed after two months.\n\nThere was no funding source for this study.", "doi": "10.1016/j.lanepe.2022.100466", "pmid": "35855494", "labels": {"Topics: Register-based research": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(22)00162-4"}, {"db": "pmc", "key": "PMC9277096"}], "notes": [], "created": "2022-08-12T08:48:27.521Z", "modified": "2022-08-12T08:48:27.527Z"}, {"entity": "publication", "iuid": "731c3b854fdd4693bbf5054df50f6f20", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/731c3b854fdd4693bbf5054df50f6f20.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/731c3b854fdd4693bbf5054df50f6f20"}}, "title": "Community-based response to the COVID-19 pandemic: case study of a home isolation centre using flexible surge capacity.", "authors": [{"family": "Phattharapornjaroen", "given": "P", "initials": "P"}, {"family": "Carlstr\u00f6m", "given": "E", "initials": "E"}, {"family": "Sivarak", "given": "O", "initials": "O"}, {"family": "Tansuwannarat", "given": "P", "initials": "P"}, {"family": "Chalermdamrichai", "given": "P", "initials": "P"}, {"family": "Sittichanbuncha", "given": "Y", "initials": "Y"}, {"family": "Kongtoranin", "given": "L", "initials": "L"}, {"family": "Phattranonuthai", "given": "R", "initials": "R"}, {"family": "Marlow", "given": "P", "initials": "P"}, {"family": "Winyuchonjaroen", "given": "W", "initials": "W"}, {"family": "Pongpasupa", "given": "N", "initials": "N"}, {"family": "Khorram-Manesh", "given": "A", "initials": "A"}], "type": "journal article", "published": "2022-07-13", "journal": {"title": "Public Health", "issn": "1476-5616", "volume": "211", "pages": "29-36", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) has consumed many available resources within contingency plans, necessitating new capacity surges and novel approaches. This study aimed to explore the possibility of implementing the concept of flexible surge capacity to reduce the burden on hospitals by focussing on community resources to develop home isolation centres in Bangkok, Thailand.\n\nA qualitative study consisted of observational and semi-structured interview data.\n\nThe development and activities of home isolation centres were observed, and interviews were conducted with leaders and operational workforces. Data were deductively analysed and categorised based on the practical elements necessary in disaster and emergency management.\n\nData were categorised into the seven collaborative elements of the major incident medical management and support model. The command-and-control category demonstrated four subcategories: (1) coordination and collaboration; (2) staff engagement; (3) responsibility clarification; and (4) sustainability. Safety presented two subcategories: (1) patients' information privacy and treatment; and (2) personnel safety and privacy. Communication showed internal and external communications subcategories. Assessment, triage, treatment and transport followed the processes of the COVID-19 treatment protocols according to the World Health Organisation (WHO) guidelines and hospital operations. Several supply- and patient-related challenges were identified and managed during centre development.\n\nThe use of community resources, based on the flexible surge capacity concept, is feasible under restricted circumstances and reduced the burden on hospitals during the COVID-19 pandemic. Continuous education among multidisciplinary volunteer teams facilitated their full participation and engagement. The concept of flexible surge capacity may promote an alternative community-based care opportunity, irrespective of emergencies' aetiology.", "doi": "10.1016/j.puhe.2022.06.025", "pmid": "35994836", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0033-3506(22)00182-2"}, {"db": "pmc", "key": "PMC9276643"}], "notes": [], "created": "2022-09-12T19:00:44.873Z", "modified": "2022-09-12T19:00:56.112Z"}, {"entity": "publication", "iuid": "9e30c2527eb24c79b180aa68c68b2d26", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9e30c2527eb24c79b180aa68c68b2d26.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9e30c2527eb24c79b180aa68c68b2d26"}}, "title": "mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells.", "authors": [{"family": "Bevers", "given": "Sanne", "initials": "S"}, {"family": "Kooijmans", "given": "Sander A A", "initials": "SAA"}, {"family": "Van de Velde", "given": "Elien", "initials": "E"}, {"family": "Evers", "given": "Martijn J W", "initials": "MJW"}, {"family": "Seghers", "given": "Sofie", "initials": "S"}, {"family": "Gitz-Francois", "given": "Jerney J J M", "initials": "JJJM"}, {"family": "van Kronenburg", "given": "Nicky C H", "initials": "NCH"}, {"family": "Fens", "given": "Marcel H A M", "initials": "MHAM"}, {"family": "Mastrobattista", "given": "Enrico", "initials": "E"}, {"family": "Hassler", "given": "Lucie", "initials": "L"}, {"family": "Sork", "given": "Helena", "initials": "H"}, {"family": "Lehto", "given": "Taavi", "initials": "T"}, {"family": "Ahmed", "given": "Kariem E", "initials": "KE"}, {"family": "El Andaloussi", "given": "Samir", "initials": "S"}, {"family": "Fiedler", "given": "Katja", "initials": "K"}, {"family": "Breckpot", "given": "Karine", "initials": "K"}, {"family": "Maes", "given": "Michael", "initials": "M"}, {"family": "Van Hoorick", "given": "Diane", "initials": "D"}, {"family": "Bastogne", "given": "Thierry", "initials": "T"}, {"family": "Schiffelers", "given": "Raymond M", "initials": "RM"}, {"family": "De Koker", "given": "Stefaan", "initials": "S"}], "type": "journal article", "published": "2022-07-12", "journal": {"title": "Mol Ther", "issn": "1525-0024", "issn-l": null}, "abstract": "mRNA vaccines have recently proved to be highly effective against SARS-CoV-2. Key to their success is the lipid-based nanoparticle (LNP), which enables efficient mRNA expression and endows the vaccine with adjuvant properties that drive potent antibody responses. Effective cancer vaccines require long-lived, qualitative CD8 T cell responses instead of antibody responses. Systemic vaccination appears to be the most effective route, but necessitates adaptation of LNP composition to deliver mRNA to antigen-presenting cells. Using a design-of-experiments methodology, we tailored mRNA-LNP compositions to achieve high-magnitude tumor-specific CD8 T cell responses within a single round of optimization. Optimized LNP compositions resulted in enhanced mRNA uptake by multiple splenic immune cell populations. Type I interferon and phagocytes were found to be essential for the T cell response. Surprisingly, we also discovered a yet unidentified role of B cells in stimulating the vaccine-elicited CD8 T cell response. Optimized LNPs displayed a similar, spleen-centered biodistribution profile in non-human primates and did not trigger histopathological changes in liver and spleen, warranting their further assessment in clinical studies. Taken together, our study clarifies the relationship between nanoparticle composition and their T cell stimulatory capacity and provides novel insights into the underlying mechanisms of effective mRNA-LNP-based antitumor immunotherapy.", "doi": "10.1016/j.ymthe.2022.07.007", "pmid": "35821637", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S1525-0016(22)00428-2"}, {"db": "pmc", "key": "PMC9273295"}], "notes": [], "created": "2022-08-17T10:36:40.221Z", "modified": "2022-08-17T10:36:52.133Z"}, {"entity": "publication", "iuid": "c1c8534aa33042ff8fe7fa5a16399331", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1c8534aa33042ff8fe7fa5a16399331.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1c8534aa33042ff8fe7fa5a16399331"}}, "title": "Working conditions for hospital-based maternity and neonatal health care workers during extraordinary situations - A pre-/post COVID-19 pandemic analysis and lessons learned.", "authors": [{"family": "Akerstrom", "given": "Magnus", "initials": "M"}, {"family": "Carlsson", "given": "Ylva", "initials": "Y"}, {"family": "Sengpiel", "given": "Verena", "initials": "V"}, {"family": "Veje", "given": "Malin", "initials": "M"}, {"family": "Elfvin", "given": "Anders", "initials": "A"}, {"family": "Jonsdottir", "given": "Ingibj\u00f6rg H", "initials": "IH"}, {"family": "Degl'Innocenti", "given": "Alessio", "initials": "A"}, {"family": "Ahlstrom", "given": "Linda", "initials": "L"}, {"family": "Wijk", "given": "Helle", "initials": "H"}, {"family": "Linden", "given": "Karolina", "initials": "K"}], "type": "journal article", "published": "2022-07-12", "journal": {"title": "Sex Reprod Healthc", "issn": "1877-5764", "volume": "33", "pages": "100755", "issn-l": null}, "abstract": "The aim of this study was to investigate how the changed work routines during the COVID-19 pandemic has been affecting the working environment for hospital-based maternity and neonatal health care workers, and to identify preventive measures to be used in future situations when health care organizations are under pressure.\n\nAll maternity and neonatal health care workers in a Swedish university hospital were surveyed during October 2019 and September 2020. The data was analyzed by document analysis of implemented changes in working routines, a quantitative analysis of the overall effects on the working conditions, and a qualitative analysis of open-ended responses.\n\nA total of 660 maternity and neonatal health care workers completed the pre-COVID-19 survey (74% response rate) and 382 the COVID-19 survey (35% response rate). Lack of personal protective equipment, worry about becoming infected, uncertainty whether implemented changes were enough, and challenges in communicating updated routines had negative effects on maternity and neonatal health care workers' working conditions. Team spirit and feeling valued by peers had a positive effect.\n\nResults suggest that negative effects on maternity and neonatal health care workers' health can partly be prevented in future critical situations by creating a work climate that acknowledges the employees' worry about being infected, securing adequate pre-conditions for managers, creating a strong psychosocial safety climate and systematically improving the working conditions for the maternity and neonatal health care workers, as well as maintaining the positive perceived effects of increased team spirit and feeling valued by peers.", "doi": "10.1016/j.srhc.2022.100755", "pmid": "35853385", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1877-5756(22)00061-1"}, {"db": "pmc", "key": "PMC9273518"}], "notes": [], "created": "2022-08-12T08:50:16.161Z", "modified": "2022-08-12T08:50:16.166Z"}, {"entity": "publication", "iuid": "77d56ca741194f1b8a8d8f00738a6877", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/77d56ca741194f1b8a8d8f00738a6877.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/77d56ca741194f1b8a8d8f00738a6877"}}, "title": "School Nurses' Perceptions About Student's Wellbeing During the Covid-19 Pandemic in Sweden.", "authors": [{"family": "Martinsson", "given": "Eva", "initials": "E"}, {"family": "Garmy", "given": "Pernilla", "initials": "P", "orcid": "0000-0003-1643-0171", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc4733a9e87a42fea6e7a7323feb61b3.json"}}, {"family": "Einberg", "given": "Eva-Lena", "initials": "EL", "orcid": "0000-0002-5586-3810", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d67e636861d492fb682ec1601422cd0.json"}}], "type": "journal article", "published": "2022-07-12", "journal": {"title": "J Sch Nurs", "issn": "1546-8364", "pages": "10598405221112443", "issn-l": null}, "abstract": "The coronavirus 2019 (Covid-19) pandemic has affected both the private and public lives of people worldwide. Countries have chosen different strategies to reduce the spread of infection, including school closures and distance learning. This study aimed to describe school nurses' perceptions about the wellbeing of students during the Covid-19 pandemic in Sweden. Interviews in five focus groups and one individual were conducted with 17 school nurses in Sweden. The interviews were analyzed using a qualitative content analysis. According to the school nurses' perceptions, students were concerned about spreading infection, becoming infected themselves, their academic performances, and longing for socialization. The change in the school situation involved a slower pace and less anxiety for some students, more or less physical activity, and an increase in screen time.", "doi": "10.1177/10598405221112443", "pmid": "35822231", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9280116"}], "notes": [], "created": "2022-08-17T10:36:15.715Z", "modified": "2022-08-17T10:36:15.752Z"}, {"entity": "publication", "iuid": "ccdb507805c448e09e20070e7245ba29", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ccdb507805c448e09e20070e7245ba29.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ccdb507805c448e09e20070e7245ba29"}}, "title": "Prevalence of fatigue at one-year follow-up from the Gothenburg recovery and rehabilitation after COVID-19 and intensive care unit study.", "authors": [{"family": "Hussain", "given": "Netha", "initials": "N"}, {"family": "Samuelsson", "given": "Carina M", "initials": "CM"}, {"family": "Drummond", "given": "Avril", "initials": "A"}, {"family": "Persson", "given": "Carina U", "initials": "CU"}], "type": "journal article", "published": "2022-07-12", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "11501", "issn-l": "2045-2322"}, "abstract": "Fatigue was a commonly reported sequala after COVID-19. However, there is little literature about the prevalence and predictors of fatigue one year after Intensive Care Unit (ICU) admission following COVID-19. Therefore, the aim of this study was to determine the prevalence of fatigue and to identify the predictors prior to, and during the care period in ICU that were associated with fatigue at one year after ICU admission following COVID-19. The dependent variable, fatigue, was assessed using the Swedish version of Fatigue Assessment Scale (S-FAS), in a cohort of 105 individuals cared for at the ICU at the Sahlgrenska University hospital, Sweden during the first wave of the pandemic. The independent variables were related to demographic factors, comorbidities and complications during ICU admission following COVID-19. Fatigue was reported by 64.4% (n = 67) of the individuals. Age (odds ratio: 0.95, confidence interval: 0.92-0.99) and length of stay in the ICU (odds ratio: 1.04, confidence interval: 1.00-1.07) were statistically significant predictors of fatigue one year after ICU admission following COVID-19. The findings from this study will be important for healthcare practitioners, policy makers and the general public in planning the rehabilitation of individuals who underwent ICU care for COVID-19.", "doi": "10.1038/s41598-022-14787-6", "pmid": "35821226", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-14787-6"}, {"db": "pmc", "key": "PMC9276681"}], "notes": [], "created": "2022-08-17T10:37:13.798Z", "modified": "2022-08-17T10:37:13.811Z"}, {"entity": "publication", "iuid": "0fd3e4f3d2f8406f88be2ebd9ec8eef9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0fd3e4f3d2f8406f88be2ebd9ec8eef9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0fd3e4f3d2f8406f88be2ebd9ec8eef9"}}, "title": "Directly immersible silicon photonic probes: Application to rapid SARS-CoV-2 serological testing.", "authors": [{"family": "Angelopoulou", "given": "Michailia", "initials": "M"}, {"family": "Makarona", "given": "Eleni", "initials": "E"}, {"family": "Salapatas", "given": "Alexandros", "initials": "A"}, {"family": "Misiakos", "given": "Konstantinos", "initials": "K"}, {"family": "Synolaki", "given": "Evgenia", "initials": "E"}, {"family": "Ioannidis", "given": "Anastasios", "initials": "A"}, {"family": "Chatzipanagiotou", "given": "Stylianos", "initials": "S"}, {"family": "Ritvos", "given": "Mikael A", "initials": "MA"}, {"family": "Pasternack", "given": "Arja", "initials": "A"}, {"family": "Ritvos", "given": "Olli", "initials": "O"}, {"family": "Petrou", "given": "Panagiota S", "initials": "PS"}, {"family": "Kakabakos", "given": "Sotirios E", "initials": "SE"}], "type": "journal article", "published": "2022-07-12", "journal": {"title": "Biosens Bioelectron", "issn": "1873-4235", "volume": "215", "pages": "114570", "issn-l": null}, "abstract": "Silicon photonic probes based on broad-band Mach-Zehnder interferometry are explored for the first time as directly immersible immunosensors alleviating the need for microfluidics and pumps. Each probe includes two U-shaped waveguides allowing light in- and out-coupling from the same chip side through a bifurcated fiber and a mechanical coupler. At the opposite chip side, two Mach-Zehnder interferometers (MZI) are located enabling real-time monitoring of binding reactions by immersion of this chip side into a sample. The sensing arm windows of the two MZIs have different length resulting in two distinct peaks in the Fourier domain, the phase shift of which can be monitored independently through Fast Fourier Transform of the output spectrum. The photonic probes analytical potential was demonstrated through detection of antibodies against SARS-CoV-2 in human serum samples. For this, one MZI was functionalized with the Receptor Binding Domain (RBD) of SARS-CoV-2 Spike 1 protein, and the other with bovine serum albumin to serve as reference. The biofunctionalized probes were immersed for 10 min in human serum sample and then for 5 min in goat anti-human IgG Fc specific antibody solution. Using a humanized rat antibody against SARS-CoV-2 RBD, a detection limit of 20 ng/mL was determined. Analysis of human serum samples indicated that the proposed sensor discriminated completely non-infected/non-vaccinated from vaccinated individuals, and the antibodies levels determined correlated well with those determined in the same samples by ELISA. These results demonstrated the potential of the proposed sensor to serve as an efficient tool for expeditious point-of-care testing.", "doi": "10.1016/j.bios.2022.114570", "pmid": "35850040", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0956-5663(22)00610-8"}, {"db": "pmc", "key": "PMC9273522"}], "notes": [], "created": "2022-08-12T08:51:43.044Z", "modified": "2022-08-12T08:51:43.074Z"}, {"entity": "publication", "iuid": "dec4fedc676d4600898cf479f3c3f403", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dec4fedc676d4600898cf479f3c3f403.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dec4fedc676d4600898cf479f3c3f403"}}, "title": "Clinical prediction models for mortality in patients with covid-19: external validation and individual participant data meta-analysis.", "authors": [{"family": "de Jong", "given": "Valentijn M T", "initials": "VMT", "orcid": "0000-0001-9921-3468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5147390937d4bdbb706fd24820bdabc.json"}}, {"family": "Rousset", "given": "Rebecca Z", "initials": "RZ", "orcid": "0000-0001-9355-7286", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/657ff3d472c94b598267473a115a9a24.json"}}, {"family": "Antonio-Villa", "given": "Neftal\u00ed Eduardo", "initials": "NE", "orcid": "0000-0002-6879-1078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2f6ed0f02a24c9db9ec0a0f2a138302.json"}}, {"family": "Buenen", "given": "Arnoldus G", "initials": "AG", "orcid": "0000-0002-0948-1379", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c3427d44e1d840729a381a2a95fd13c2.json"}}, {"family": "Van Calster", "given": "Ben", "initials": "B", "orcid": "0000-0003-1613-7450", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47c7125c051c47b58e7a6462f2ddc79b.json"}}, {"family": "Bello-Chavolla", "given": "Omar Yaxmehen", "initials": "OY", "orcid": "0000-0003-3093-937X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/17af31a1a5914f5bbfa87a312ffdc995.json"}}, {"family": "Brunskill", "given": "Nigel J", "initials": "NJ"}, {"family": "Curcin", "given": "Vasa", "initials": "V", "orcid": "0000-0002-8308-2886", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91c85856301d422b8071753e1d36fd31.json"}}, {"family": "Damen", "given": "Johanna A A", "initials": "JAA", "orcid": "0000-0001-7401-4593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b6107f804af47a3a2b27ceeb6ade6ca.json"}}, {"family": "Ferm\u00edn-Mart\u00ednez", "given": "Carlos A", "initials": "CA", "orcid": "0000-0001-5627-8851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10fdb216049244a6a7d87788674e9a4e.json"}}, {"family": "Fern\u00e1ndez-Chirino", "given": "Luisa", "initials": "L", "orcid": "0000-0002-8326-1219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c06b680084d548d88e4b29e70ed06be4.json"}}, {"family": "Ferrari", "given": "Davide", "initials": "D", "orcid": "0000-0003-2365-4157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/419cc33149304e7ab894b00491377ffd.json"}}, {"family": "Free", "given": "Robert C", "initials": "RC"}, {"family": "Gupta", "given": "Rishi K", "initials": "RK", "orcid": "0000-0002-6257-1285", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/199d63fa58c84f44ba02d388cf89bdb7.json"}}, {"family": "Haldar", "given": "Pranabashis", "initials": "P"}, {"family": "Hedberg", "given": "Pontus", "initials": "P", "orcid": "0000-0003-3153-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd6af5accfc84ff9a81983a5ab6683aa.json"}}, {"family": "Korang", "given": "Steven Kwasi", "initials": "SK", "orcid": "0000-0002-6521-0928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a3fa688bba644138b31d213fefeb31e.json"}}, {"family": "Kurstjens", "given": "Steef", "initials": "S"}, {"family": "Kusters", "given": "Ron", "initials": "R"}, {"family": "Major", "given": "Rupert W", "initials": "RW", "orcid": "0000-0003-4920-623X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/853c99a3b7b149c8a0b6f28d29013785.json"}}, {"family": "Maxwell", "given": "Lauren", "initials": "L"}, {"family": "Nair", "given": "Rajeshwari", "initials": "R"}, {"family": "Naucler", "given": "Pontus", "initials": "P", "orcid": "0000-0002-8185-2648", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78b415aee4864810b8ce8f1962fa288f.json"}}, {"family": "Nguyen", "given": "Tri-Long", "initials": "TL", "orcid": "0000-0002-6376-7212", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4869454669049bab81bb55809f3a446.json"}}, {"family": "Noursadeghi", "given": "Mahdad", "initials": "M"}, {"family": "Rosa", "given": "Rossana", "initials": "R", "orcid": "0000-0002-3755-7780", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13954374ed884b65b833316c1ce8991d.json"}}, {"family": "Soares", "given": "Felipe", "initials": "F", "orcid": "0000-0002-2837-1853", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7f180e740e4496b867c75535a5ddf2c.json"}}, {"family": "Takada", "given": "Toshihiko", "initials": "T", "orcid": "0000-0002-8032-6224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/285f5b69f2c741c3a6e7b268123c5a97.json"}}, {"family": "van Royen", "given": "Florien S", "initials": "FS", "orcid": "0000-0002-6785-214X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d92466b48a0e43f5aa2e326eff1457d6.json"}}, {"family": "van Smeden", "given": "Maarten", "initials": "M", "orcid": "0000-0002-5529-1541", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8dd2487a416242099bd2dffdc5d05be9.json"}}, {"family": "Wynants", "given": "Laure", "initials": "L", "orcid": "0000-0002-3037-122X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb8e9ef168d444e9b821f22e9a4e06ff.json"}}, {"family": "Modr\u00e1k", "given": "Martin", "initials": "M", "orcid": "0000-0002-8886-7797", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e1aceac9a864506b36dbfddab9608c5.json"}}, {"family": "CovidRetro collaboration", "given": "", "initials": ""}, {"family": "Asselbergs", "given": "Folkert W", "initials": "FW", "orcid": "0000-0002-1692-8669", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/578ce5a865454ff3be1545f940cabbdc.json"}}, {"family": "Linschoten", "given": "Marijke", "initials": "M", "orcid": "0000-0002-4541-080X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7714859c3fc420088a20cf23eda12cb.json"}}, {"family": "CAPACITY-COVID consortium", "given": "", "initials": ""}, {"family": "Moons", "given": "Karel G M", "initials": "KGM"}, {"family": "Debray", "given": "Thomas P A", "initials": "TPA", "orcid": "0000-0002-1790-2719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/343d2f07d494422f91507fd6bca0dcad.json"}}], "type": "journal article", "published": "2022-07-12", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "378", "pages": "e069881", "issn-l": null}, "abstract": "To externally validate various prognostic models and scoring rules for predicting short term mortality in patients admitted to hospital for covid-19.\n\nTwo stage individual participant data meta-analysis.\n\nSecondary and tertiary care.\n\n46 914 patients across 18 countries, admitted to a hospital with polymerase chain reaction confirmed covid-19 from November 2019 to April 2021.\n\nMultiple (clustered) cohorts in Brazil, Belgium, China, Czech Republic, Egypt, France, Iran, Israel, Italy, Mexico, Netherlands, Portugal, Russia, Saudi Arabia, Spain, Sweden, United Kingdom, and United States previously identified by a living systematic review of covid-19 prediction models published in The BMJ, and through PROSPERO, reference checking, and expert knowledge.\n\nPrognostic models identified by the living systematic review and through contacting experts. A priori models were excluded that had a high risk of bias in the participant domain of PROBAST (prediction model study risk of bias assessment tool) or for which the applicability was deemed poor.\n\nEight prognostic models with diverse predictors were identified and validated. A two stage individual participant data meta-analysis was performed of the estimated model concordance (C) statistic, calibration slope, calibration-in-the-large, and observed to expected ratio (O:E) across the included clusters.\n\n30 day mortality or in-hospital mortality.\n\nDatasets included 27 clusters from 18 different countries and contained data on 46 914patients. The pooled estimates ranged from 0.67 to 0.80 (C statistic), 0.22 to 1.22 (calibration slope), and 0.18 to 2.59 (O:E ratio) and were prone to substantial between study heterogeneity. The 4C Mortality Score by Knight et al (pooled C statistic 0.80, 95% confidence interval 0.75 to 0.84, 95% prediction interval 0.72 to 0.86) and clinical model by Wang et al (0.77, 0.73 to 0.80, 0.63 to 0.87) had the highest discriminative ability. On average, 29% fewer deaths were observed than predicted by the 4C Mortality Score (pooled O:E 0.71, 95% confidence interval 0.45 to 1.11, 95% prediction interval 0.21 to 2.39), 35% fewer than predicted by the Wang clinical model (0.65, 0.52 to 0.82, 0.23 to 1.89), and 4% fewer than predicted by Xie et al's model (0.96, 0.59 to 1.55, 0.21 to 4.28).\n\nThe prognostic value of the included models varied greatly between the data sources. Although the Knight 4C Mortality Score and Wang clinical model appeared most promising, recalibration (intercept and slope updates) is needed before implementation in routine care.", "doi": "10.1136/bmj-2021-069881", "pmid": "35820692", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9273913"}], "notes": [], "created": "2022-08-17T10:37:35.184Z", "modified": "2022-08-17T10:37:36.106Z"}, {"entity": "publication", "iuid": "81ad262b687b4469a0d28c40a200cfb4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/81ad262b687b4469a0d28c40a200cfb4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/81ad262b687b4469a0d28c40a200cfb4"}}, "title": "Impact of COVID-19 pandemic on families living with autism: An online survey.", "authors": [{"family": "Isensee", "given": "Corinna", "initials": "C"}, {"family": "Schmid", "given": "Benjamin", "initials": "B"}, {"family": "Marschik", "given": "Peter B", "initials": "PB"}, {"family": "Zhang", "given": "Dajie", "initials": "D"}, {"family": "Poustka", "given": "Luise", "initials": "L"}], "type": "journal article", "published": "2022-07-11", "journal": {"title": "Res Dev Disabil", "issn": "1873-3379", "volume": "129", "pages": "104307", "issn-l": null}, "abstract": "The current SARS-CoV-2 global pandemic presents a great challenge for governments, health care professionals and the general population. Individuals with autism spectrum disorder (ASD) might be especially vulnerable to restrictions imposed by the crisis.\n\nThe objective of the study was to examine the impact of the SARSCoV- 2 pandemic on children with ASD and their families.\n\nWe conducted an online survey two months after the beginning of lock-down (18th of May to 5th of July 2020) in Germany and Austria. We investigated behavioral and emotional changes of children related to the lock-down alongside parental stress and intrafamilial burden OUTCOME AND RESULTS: Of the 216 participating families with an autistic child (mean age: 12.23 years), nearly 50% reported aggravation of autistic symptoms and heightened parental stress. Families reported discontinuation of therapy, more intrafamilial conflicts and increase of psychopharmacological medication of the child.\n\nOur report on short-term detrimental effects of the pandemic calls for thorough investigation of long-term sequalae for children and families.", "doi": "10.1016/j.ridd.2022.104307", "pmid": "35908370", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0891-4222(22)00137-8"}, {"db": "pmc", "key": "PMC9271458"}], "notes": [], "created": "2022-08-12T08:31:03.122Z", "modified": "2022-08-12T08:31:03.149Z"}, {"entity": "publication", "iuid": "f6c3188e1df54926b231706fa4c42a81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6c3188e1df54926b231706fa4c42a81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6c3188e1df54926b231706fa4c42a81"}}, "title": "IMpact of COVID-19 in Patients With Severe Alpha-1 Antitrypsin Deficiency: The IMCA1 Study of the EARCO Clinical Research Collaboration.", "authors": [{"family": "Parr", "given": "David G", "initials": "DG"}, {"family": "Chorostowska-Wynimko", "given": "Joanna", "initials": "J"}, {"family": "Corsico", "given": "Angelo", "initials": "A"}, {"family": "Esquinas", "given": "Cristina", "initials": "C"}, {"family": "McElvaney", "given": "Gerard N", "initials": "GN"}, {"family": "Sark", "given": "Annelot D", "initials": "AD"}, {"family": "Sucena", "given": "Maria", "initials": "M"}, {"family": "Tanash", "given": "Hanan", "initials": "H"}, {"family": "Turner", "given": "Alice M", "initials": "AM"}, {"family": "Miravitlles", "given": "Marc", "initials": "M"}], "type": "case reports", "published": "2022-07-11", "journal": {"title": "Arch Bronconeumol", "issn": "1579-2129", "issn-l": null}, "abstract": null, "doi": "10.1016/j.arbres.2022.07.002", "pmid": "35879122", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0300-2896(22)00488-4"}, {"db": "pmc", "key": "PMC9272568"}], "notes": [], "created": "2022-08-12T08:38:44.333Z", "modified": "2022-08-12T08:38:44.362Z"}, {"entity": "publication", "iuid": "7342214e725c4fedba1cba39059bd007", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7342214e725c4fedba1cba39059bd007.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7342214e725c4fedba1cba39059bd007"}}, "title": "Building Process-Oriented Data Science Solutions for Real-World Healthcare.", "authors": [{"family": "Fernandez-Llatas", "given": "Carlos", "initials": "C", "orcid": "0000-0002-2819-5597", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/571fddd1da9f4a4cab2c5b3a35e1214e.json"}}, {"family": "Martin", "given": "Niels", "initials": "N", "orcid": "0000-0003-3279-3853", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7adc49ffd4c04f5990561757d9b05060.json"}}, {"family": "Johnson", "given": "Owen", "initials": "O"}, {"family": "Sepulveda", "given": "Marcos", "initials": "M", "orcid": "0000-0002-9467-7666", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46fce16f5df54618aabfb09089b1057f.json"}}, {"family": "Helm", "given": "Emmanuel", "initials": "E", "orcid": "0000-0002-1323-3511", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/909fe49fc92243eaab55745571d20610.json"}}, {"family": "Munoz-Gama", "given": "Jorge", "initials": "J", "orcid": "0000-0002-6908-3911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/217b35c6e73f4c5b91e953948735f8c8.json"}}], "type": "editorial", "published": "2022-07-10", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "14", "issn-l": null}, "abstract": "The COVID-19 pandemic has highlighted some of the opportunities, problems and barriers facing the application of Artificial Intelligence to the medical domain. It is becoming increasingly important to determine how Artificial Intelligence will help healthcare providers understand and improve the daily practice of medicine. As a part of the Artificial Intelligence research field, the Process-Oriented Data Science community has been active in the analysis of this situation and in identifying current challenges and available solutions. We have identified a need to integrate the best efforts made by the community to ensure that promised improvements to care processes can be achieved in real healthcare. In this paper, we argue that it is necessary to provide appropriate tools to support medical experts and that frequent, interactive communication between medical experts and data miners is needed to co-create solutions. Process-Oriented Data Science, and specifically concrete techniques such as Process Mining, can offer an easy to manage set of tools for developing understandable and explainable Artificial Intelligence solutions. Process Mining offers tools, methods and a data driven approach that can involve medical experts in the process of co-discovering real-world evidence in an interactive way. It is time for Process-Oriented Data scientists to collaborate more closely with healthcare professionals to provide and build useful, understandable solutions that answer practical questions in daily practice. With a shared vision, we should be better prepared to meet the complex challenges that will shape the future of healthcare.", "doi": "10.3390/ijerph19148427", "pmid": "35886279", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "ijerph19148427"}, {"db": "pmc", "key": "PMC9318799"}], "notes": [], "created": "2022-08-12T08:35:57.278Z", "modified": "2022-08-12T08:35:57.470Z"}, {"entity": "publication", "iuid": "94bf1b1dc8d44a16aecfb754f15419aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/94bf1b1dc8d44a16aecfb754f15419aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/94bf1b1dc8d44a16aecfb754f15419aa"}}, "title": "Epilepsy diagnosis after Covid-19: A population-wide study.", "authors": [{"family": "Westman", "given": "Gabriel", "initials": "G"}, {"family": "Zelano", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2022-07-09", "journal": {"title": "Seizure", "issn": "1532-2688", "volume": "101", "pages": "11-14", "issn-l": null}, "abstract": "We aimed to investigate whether SARS-CoV-2 infection was associated with an increased risk of incident epilepsy.\n\nNational register-based matched study. Verified cases of SARS-CoV-2 infection were acquired from the system for communicable disease surveillance in Sweden (SmiNet) and linked to data from the National Patient Register (NPR) and Cause of Death register in Sweden. Cases and non-infected controls were compared using a Cox proportional hazards model.\n\nA total of 1,221,801 SARS-CoV-2 infected patients and 1,223,312 controls were included. Infection was not associated with an increased risk of epilepsy on a whole population level (HR 1.01, 95% CI 0.92-1.12). Statistically significant effects were observed in patients between 61 and 80 years (HR 1.66, 95% CI 1.37-2.02), also when adjusting for stroke, traumatic brain injury, tumours (same age group HR 1.50, 95% CI 1.24-1.82) and mechanical ventilation (HR 1.28, 95% CI 1.05-1.57). In patients 81-100 years, a similar significant difference was observed (HR 1.77, 95% CI 1.30-2.42), which remained after adjustment for stroke, traumatic brain injury and tumours (HR 1.51, 95% CI 1.10-2.05) but not when mechanical ventilation was included as a covariate (HR 1.34, 95% CI 0.97-1.84).\n\nOn a whole population level, SARS-CoV-2 infections is not associated with an increased risk of epilepsy. In patients above 60 years, a moderately increased risk of epilepsy was observed. However, considering potential non-controllable bias and that Covid-19 patients in intensive care present with a lower risk than the general ICU population, the virus-induced epileptogenic effect is likely very small.", "doi": "10.1016/j.seizure.2022.07.005", "pmid": "35842976", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1059-1311(22)00158-3"}, {"db": "pmc", "key": "PMC9270960"}], "notes": [], "created": "2022-08-12T08:54:07.719Z", "modified": "2022-08-12T08:54:48.844Z"}, {"entity": "publication", "iuid": "f6c12008f39a4cfaa851666b5c3309d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6c12008f39a4cfaa851666b5c3309d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6c12008f39a4cfaa851666b5c3309d4"}}, "title": "Differences between Omicron SARS-CoV-2 RBD and other variants in their ability to interact with cell receptors and monoclonal antibodies.", "authors": [{"family": "Giron", "given": "Carolina Corr\u00eaa", "initials": "CC"}, {"family": "Laaksonen", "given": "Aatto", "initials": "A"}, {"family": "Barroso da Silva", "given": "Fernando Lu\u00eds", "initials": "FL"}], "type": "journal article", "published": "2022-07-09", "journal": {"title": "J Biomol Struct Dyn", "issn": "1538-0254", "pages": "1-21", "issn-l": null}, "abstract": "SARS-CoV-2 remains a health threat with the continuous emergence of new variants. This work aims to expand the knowledge about the SARS-CoV-2 receptor-binding domain (RBD) interactions with cell receptors and monoclonal antibodies (mAbs). By using constant-pH Monte Carlo simulations, the free energy of interactions between the RBD from different variants and several partners (Angiotensin-Converting Enzyme-2 (ACE2) polymorphisms and various mAbs) were predicted. Computed RBD-ACE2-binding affinities were higher for two ACE2 polymorphisms (rs142984500 and rs4646116) typically found in Europeans which indicates a genetic susceptibility. This is amplified for Omicron (BA.1) and its sublineages BA.2 and BA.3. The antibody landscape was computationally investigated with the largest set of mAbs so far in the literature. From the 32 studied binders, groups of mAbs were identified from weak to strong binding affinities (e.g. S2K146). These mAbs with strong binding capacity and especially their combination are amenable to experimentation and clinical trials because of their high predicted binding affinities and possible neutralization potential for current known virus mutations and a universal coronavirus.Communicated by Ramaswamy H. Sarma.", "doi": "10.1080/07391102.2022.2095305", "pmid": "35815535", "labels": {"Category: Biochemistry": null, "Category: Omicron VoC": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-17T10:38:34.796Z", "modified": "2022-08-17T10:38:34.809Z"}, {"entity": "publication", "iuid": "976ccf16ac4f43fab2c6e9abaa215b17", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/976ccf16ac4f43fab2c6e9abaa215b17.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/976ccf16ac4f43fab2c6e9abaa215b17"}}, "title": "Willingness to Accept the COVID-19 Vaccine and Related Factors among Indian Adults: A Cross-Sectional Study.", "authors": [{"family": "Parthasarathi", "given": "Ashwaghosha", "initials": "A", "orcid": "0000-0002-7270-0247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c0a5e6837a421cbbb0314628ae7f24.json"}}, {"family": "Puvvada", "given": "Rahul Krishna", "initials": "RK", "orcid": "0000-0002-4813-9509", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b593c073cfa497c985cf5f897212910.json"}}, {"family": "Shankar", "given": "Malavika", "initials": "M", "orcid": "0000-0003-0462-3988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2a17e45d5b143728f26ac2d1cb8737c.json"}}, {"family": "Siddaiah", "given": "Jayaraj Biligere", "initials": "JB", "orcid": "0000-0001-6055-4580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c8166020c084a9f8508e74cfa0b2f25.json"}}, {"family": "Ganguly", "given": "Koustav", "initials": "K", "orcid": "0000-0001-8531-8154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58b2e0d7853a4b32920e54042e95061d.json"}}, {"family": "Upadhyay", "given": "Swapna", "initials": "S", "orcid": "0000-0003-4699-4082", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c98621d4161241dd9379dca3fa6e1bf1.json"}}, {"family": "Mahesh", "given": "Padukudru Anand", "initials": "PA", "orcid": "0000-0003-1632-5945", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70c3b10ccc334c4c8195556f07c862d0.json"}}], "type": "journal article", "published": "2022-07-08", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "7", "issn-l": null}, "abstract": "To achieve herd immunity to a disease, a large portion of the population needs to be vaccinated, which is possible only when there is broad acceptance of the vaccine within the community. Thus, policymakers need to understand how the general public will perceive the vaccine. This study focused on the degree of COVID-19 vaccine hesitancy and refusal and explored sociodemographic correlations that influence vaccine hesitancy and refusal. A cross-sectional online survey was conducted among the adult population of India. The survey consisted of basic demographic questions and questions from the Vaccination Attitudes Examination (VAX) Scale. Multinomial logistical regression was used to identify correlates of vaccine hesitancy and refusal. Of the 1582 people in the study, 9% refused to become vaccinated and 30.8% were hesitant. We found that both hesitancy and refusal predictors were nearly identical (lower socioeconomic status, female gender, and older age groups), except for three groups (subjects aged 45-64 years, those with approximate income &lt;10,000 INR/month, and those residing in rural households) that showed slightly higher odds of vaccine hesitancy than refusal. We need to address the underlying sociodemographic determinants and formulate public awareness programs to address specific subgroups that are at higher risk of rejecting the vaccine and convert those who are undecided or hesitant into those willing to accept the vaccine.", "doi": "10.3390/vaccines10071095", "pmid": "35891259", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "vaccines10071095"}, {"db": "pmc", "key": "PMC9317945"}], "notes": [], "created": "2022-08-12T08:35:37.008Z", "modified": "2022-08-12T08:35:37.236Z"}, {"entity": "publication", "iuid": "bd69868678954cacbb04b9ba22d688c8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bd69868678954cacbb04b9ba22d688c8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bd69868678954cacbb04b9ba22d688c8"}}, "title": "Susceptibility to SARS-Cov-2 infection and risk for severe COVID-19 in patients with prostate cancer on androgen deprivation therapy.", "authors": [{"family": "Gedeborg", "given": "Rolf", "initials": "R", "orcid": "0000-0002-8850-7863", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/234ef51ed7854efb8bbadc3ce35bf7d9.json"}}, {"family": "Loeb", "given": "Stacy", "initials": "S"}, {"family": "Styrke", "given": "Johan", "initials": "J"}, {"family": "Kiiski-Berggren", "given": "Ritva", "initials": "R"}, {"family": "Garmo", "given": "Hans", "initials": "H"}, {"family": "Stattin", "given": "P\u00e4r", "initials": "P"}], "type": "journal article", "published": "2022-07-08", "journal": {"title": "Int J Cancer", "issn": "1097-0215", "issn-l": null}, "abstract": "Androgen deprivation therapy (ADT) has been hypothesized to protect against COVID-19, but previous observational studies of men with prostate cancer on ADT have been inconsistent regarding mortality risk from coronavirus disease 2019 (COVID-19). Using data from the Prostate Cancer data Base Sweden (PCBaSe), we identified a cohort of 114 547 men with prevalent prostate cancer on the start of follow-up in February 2020, and followed them until 16 December 2020 to evaluate the association between ADT and time to test positive for COVID-19. Among men testing positive for COVID-19, we used regression analyses to estimate the association between ADT and risk of COVID-19-related hospital admission/death from any cause within 30 days of the positive test. In total, 1695 men with prostate cancer tested positive for COVID-19. In crude analyses, exposure to ADT was associated with a 3-fold increased risk of both testing positive for COVID-19 infection and subsequent hospital admission/death. Adjustment for age, comorbidity and prostate cancer risk category substantially attenuated the associations: HR 1.3 (95% CI: 1.1-1.5) for testing positive for COVID-19, and OR 1.4 (95% CI: 1.0-1.9) for risk of subsequent hospital admission/death. In conclusion, although these results suggest increased risks of a positive COVID-19 test, and COVID-19-related hospital admission/death in men on ADT, these findings are likely explained by confounding by old age, cancer-associated morbidity and other comorbidities being more prevalent in men on ADT, rather than a direct effect of the therapy.", "doi": "10.1002/ijc.34204", "pmid": "35802468", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9349425"}], "notes": [], "created": "2022-08-17T10:44:51.277Z", "modified": "2022-08-17T10:44:51.330Z"}, {"entity": "publication", "iuid": "c631eaa6b4ca46d28bcbdd61e322c012", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c631eaa6b4ca46d28bcbdd61e322c012.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c631eaa6b4ca46d28bcbdd61e322c012"}}, "title": "Multi-omics personalized network analyses highlight progressive disruption of central metabolism associated with COVID-19 severity.", "authors": [{"family": "Ambikan", "given": "Anoop T", "initials": "AT"}, {"family": "Yang", "given": "Hong", "initials": "H"}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Svensson Akusj\u00e4rvi", "given": "Sara", "initials": "S"}, {"family": "Gupta", "given": "Soham", "initials": "S"}, {"family": "Lourda", "given": "Magda", "initials": "M"}, {"family": "Sperk", "given": "Maike", "initials": "M"}, {"family": "Arif", "given": "Muhammad", "initials": "M"}, {"family": "Zhang", "given": "Cheng", "initials": "C"}, {"family": "Nordqvist", "given": "Hampus", "initials": "H"}, {"family": "Ponnan", "given": "Sivasankaran Munusamy", "initials": "SM"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Treutiger", "given": "Carl Johan", "initials": "CJ"}, {"family": "O'Mahony", "given": "Liam", "initials": "L"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A"}, {"family": "Benfeitas", "given": "Rui", "initials": "R"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "journal article", "published": "2022-07-08", "journal": {"title": "Cell Syst", "issn": "2405-4720", "issn-l": null}, "abstract": "The clinical outcome and disease severity in coronavirus disease 2019 (COVID-19) are heterogeneous, and the progression or fatality of the disease cannot be explained by a single factor like age or comorbidities. In this study, we used system-wide network-based system biology analysis using whole blood RNA sequencing, immunophenotyping by flow cytometry, plasma metabolomics, and single-cell-type metabolomics of monocytes to identify the potential determinants of COVID-19 severity at personalized and group levels. Digital cell quantification and immunophenotyping of the mononuclear phagocytes indicated a substantial role in coordinating the immune cells that mediate COVID-19 severity. Stratum-specific and personalized genome-scale metabolic modeling indicated monocarboxylate transporter family genes (e.g., SLC16A6), nucleoside transporter genes (e.g., SLC29A1), and metabolites such as \u03b1-ketoglutarate, succinate, malate, and butyrate could play a crucial role in COVID-19 severity. Metabolic perturbations targeting the central metabolic pathway (TCA cycle) can be an alternate treatment strategy in severe COVID-19.", "doi": "10.1016/j.cels.2022.06.006", "pmid": "35933992", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2405-4712(22)00276-9"}], "notes": [], "created": "2022-08-11T11:54:54.053Z", "modified": "2022-08-11T11:55:16.618Z"}, {"entity": "publication", "iuid": "8d87314fecdf428a9ebfa402ab51f02f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d87314fecdf428a9ebfa402ab51f02f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d87314fecdf428a9ebfa402ab51f02f"}}, "title": "The need for a food allergy educator program for allied healthcare professionals in Canada.", "authors": [{"family": "Protudjer", "given": "Jennifer L P", "initials": "JLP", "orcid": "0000-0002-3888-8688", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e35d8fddae04acbb44382b43acb0147.json"}}, {"family": "Venter", "given": "Carina", "initials": "C"}, {"family": "Groetch", "given": "Marion", "initials": "M"}, {"family": "Frykas", "given": "Tara Lynn Mary", "initials": "TLM"}, {"family": "Lidington", "given": "Jasmin", "initials": "J"}, {"family": "Kim", "given": "Harold", "initials": "H"}], "type": "letter", "published": "2022-07-07", "journal": {"title": "Allergy Asthma Clin Immunol", "issn": "1710-1484", "volume": "18", "issue": "1", "pages": "62", "issn-l": null}, "abstract": "Owing to a collaborative approach to patient care, and a paucity of allergists in Canada, there is a need to develop a food allergy educational program for allied health care professionals in Canada. Such programs already exist in the United States and Britain. Herein, we describe the outcomes of recent conference proceedings to inform the educational needs for such a program. As part of the 76th Annual Meeting of the Canadian Society of Allergy and Clinical Immunology (CSACI), held virtually due to the COVID-19 pandemic, we hosted a virtual workshop on the need for a food allergy educator program for Canadian allied health professionals. This workshop was co-developed with the CSACI and an industry partner, and featured allergy specialist dietitians. Attendance was open to all conference delegates, and to allied health professionals. As part of the registration process, registrants posed diverse food allergy-related questions, ranging from how to use an epinephrine autoinjector, to daily management and, how to cure food allergy. A national food allergy educator program will empower both allergy and non-allergy specialist healthcare professionals to appropriately counsel patients. This virtually-delivered program will begin to close a gap in healthcare access resulting from the geographic size of Canada, as it will enhance allied healthcare providers' confidence to provide evidence-based food allergy care appropriately for those with food allergy.", "doi": "10.1186/s13223-022-00701-2", "pmid": "35799220", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13223-022-00701-2"}, {"db": "pmc", "key": "PMC9261880"}], "notes": [], "created": "2022-08-17T10:45:57.211Z", "modified": "2022-08-17T10:45:57.264Z"}, {"entity": "publication", "iuid": "27960d2d50744d5d9cd3007dfcc0fc84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27960d2d50744d5d9cd3007dfcc0fc84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27960d2d50744d5d9cd3007dfcc0fc84"}}, "title": "Prevalence of and risk factors for depression, anxiety, and stress in non-hospitalized asymptomatic and mild COVID-19 patients in East Java province, Indonesia.", "authors": [{"family": "Lusida", "given": "Michael Austin Pradipta", "initials": "MAP"}, {"family": "Salamah", "given": "Sovia", "initials": "S", "orcid": "0000-0002-4815-8929", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fcc2cebe9fcf490f992ad65e73622fc3.json"}}, {"family": "Jonatan", "given": "Michael", "initials": "M"}, {"family": "Wiyogo", "given": "Illona Okvita", "initials": "IO"}, {"family": "Asyari", "given": "Claudia Herda", "initials": "CH"}, {"family": "Ali", "given": "Nurarifah Destianizar", "initials": "ND"}, {"family": "Asmara", "given": "Jose", "initials": "J"}, {"family": "Wahyuningtyas", "given": "Ria Indah", "initials": "RI"}, {"family": "Triyono", "given": "Erwin Astha", "initials": "EA"}, {"family": "Ratnadewi", "given": "Ni Kadek", "initials": "NK"}, {"family": "Irzaldy", "given": "Abyan", "initials": "A"}, {"family": "Alkaff", "given": "Firas Farisi", "initials": "FF"}], "type": "journal article", "published": "2022-07-07", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "7", "pages": "e0270966", "issn-l": "1932-6203"}, "abstract": "Despite abundant data on mental health during the COVID-19 pandemic, 3 important knowledge gaps continue to exist, i.e., 1) studies from low-/middle income countries (LMICs); 2) studies in the later period of the COVID-19 pandemic; and 3) studies on non-hospitalized asymptomatic and mild COVID-19 patients. To address the knowledge gaps, we assessed the prevalence of and the risk factors for mental health symptoms among non-hospitalized asymptomatic and mild COVID-19 patients in one LMIC (Indonesia) during the later period of the pandemic.\n\nThis cross-sectional study was conducted in September 2020 in East Java province, Indonesia. Study population consisted of non-hospitalized asymptomatic and mild COVID-19 patients who were diagnosed based on reverse transcriptase-polymerase chain reaction results from nasopharyngeal swab. Mental health symptoms were evaluated using the Depression Anxiety Stress Scale-21.\n\nFrom 778 non-hospitalized asymptomatic and mild COVID-19 patients, 608 patients were included in the analysis. Patients' median age was 35 years old and 61.2% were male. Of these, 22 (3.6%) reported symptoms of depression, 87 (14.3%) reported symptoms of anxiety, and 48 (7.9%) reported symptoms of stress. Multivariate logistic regression analysis showed that females were more likely to report symptoms of stress (adjusted odds ratio (aOR) = 1.98, p-value = 0.028); healthcare workers were more likely to report symptoms of depression and anxiety (aOR = 5.57, p-value = 0.002 and aOR = 2.92, p-value = 0.014, respectively); and those with a recent history of self-quarantine were more likely to report symptoms of depression and stress (aOR 5.18, p = 0.004 and aOR = 1.86, p = 0.047, respectively).\n\nThe reported prevalence of mental health symptoms, especially depression, was relatively low among non-hospitalized asymptomatic and mild COVID-19 patients during the later period of the COVID-19 pandemic in East Java province, Indonesia. In addition, several risk factors have been identified.", "doi": "10.1371/journal.pone.0270966", "pmid": "35797394", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-21429"}, {"db": "pmc", "key": "PMC9262201"}], "notes": [], "created": "2022-08-17T10:46:19.639Z", "modified": "2022-08-17T10:46:58.176Z"}, {"entity": "publication", "iuid": "7e9ab7e05e884d09a7c7cc6bf6e16f4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e9ab7e05e884d09a7c7cc6bf6e16f4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e9ab7e05e884d09a7c7cc6bf6e16f4d"}}, "title": "Vaccine Safety Surveillance Using Routinely Collected Healthcare Data-An Empirical Evaluation of Epidemiological Designs.", "authors": [{"family": "Schuemie", "given": "Martijn J", "initials": "MJ"}, {"family": "Arshad", "given": "Faaizah", "initials": "F"}, {"family": "Pratt", "given": "Nicole", "initials": "N"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Lai", "given": "Lana Y H", "initials": "LYH"}, {"family": "Li", "given": "Xintong", "initials": "X"}, {"family": "Fortin", "given": "Stephen", "initials": "S"}, {"family": "Minty", "given": "Evan", "initials": "E"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}], "type": "journal article", "published": "2022-07-06", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "issn-l": "1663-9812", "volume": "13", "issue": null, "pages": "893484"}, "abstract": "Background: Routinely collected healthcare data such as administrative claims and electronic health records (EHR) can complement clinical trials and spontaneous reports to detect previously unknown risks of vaccines, but uncertainty remains about the behavior of alternative epidemiologic designs to detect and declare a true risk early. Methods: Using three claims and one EHR database, we evaluate several variants of the case-control, comparative cohort, historical comparator, and self-controlled designs against historical vaccinations using real negative control outcomes (outcomes with no evidence to suggest that they could be caused by the vaccines) and simulated positive control outcomes. Results: Most methods show large type 1 error, often identifying false positive signals. The cohort method appears either positively or negatively biased, depending on the choice of comparator index date. Empirical calibration using effect-size estimates for negative control outcomes can bring type 1 error closer to nominal, often at the cost of increasing type 2 error. After calibration, the self-controlled case series (SCCS) design most rapidly detects small true effect sizes, while the historical comparator performs well for strong effects. Conclusion: When applying any method for vaccine safety surveillance we recommend considering the potential for systematic error, especially due to confounding, which for many designs appears to be substantial. Adjusting for age and sex alone is likely not sufficient to address differences between vaccinated and unvaccinated, and for the cohort method the choice of index date is important for the comparability of the groups. Analysis of negative control outcomes allows both quantification of the systematic error and, if desired, subsequent empirical calibration to restore type 1 error to its nominal value. In order to detect weaker signals, one may have to accept a higher type 1 error.", "doi": "10.3389/fphar.2022.893484", "pmid": "35873596", "labels": {"Category: Vaccines": null, "Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9299244"}, {"db": "pii", "key": "893484"}], "notes": [], "created": "2023-01-13T09:56:38.927Z", "modified": "2023-01-13T10:02:34.231Z"}, {"entity": "publication", "iuid": "5a2ca13f8c3a4714b322dc44beac84e5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5a2ca13f8c3a4714b322dc44beac84e5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5a2ca13f8c3a4714b322dc44beac84e5"}}, "title": "The COVID-19 Pandemic and Adolescents' Psychological Distress: A Multinational Cross-Sectional Study.", "authors": [{"family": "Nguyen", "given": "Hang T M", "initials": "HTM"}, {"family": "Nguyen", "given": "Hoang V", "initials": "HV"}, {"family": "Zouini", "given": "Btissame", "initials": "B", "orcid": "0000-0002-9692-2397", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8935bc90d78143139467d7cfe522f70a.json"}}, {"family": "Senhaji", "given": "Meftaha", "initials": "M", "orcid": "0000-0002-1604-4038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96559d09177a4a34802d08bad5369ca0.json"}}, {"family": "Bador", "given": "Kourosh", "initials": "K", "orcid": "0000-0001-9163-6837", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a3c65199d6449119963e936c3605aca.json"}}, {"family": "Meszaros", "given": "Zsuzsa Szombathyne", "initials": "ZS", "orcid": "0000-0003-2775-0453", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb8155e02af84f868e4b8e58f8e6d73d.json"}}, {"family": "Stevanovic", "given": "Dejan", "initials": "D", "orcid": "0000-0001-8236-5246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fd2d9e3b1114cf5bd2a89e5ab0dc766.json"}}, {"family": "Kerekes", "given": "N\u00f3ra", "initials": "N", "orcid": "0000-0002-8854-0399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/175ef55a6f3b45909a0a76b55cc0e4b3.json"}}], "type": "journal article", "published": "2022-07-06", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "14", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has continued for more than two years, and the impact of this pandemic on mental health has become one of the most important research topics in psychiatry and psychology. The aim of the present study was to assess psychological distress in adolescents across five countries (Sweden, Morocco, Serbia, Vietnam, and the United States of America) during the COVID-19 pandemic.\n\nUsing nonparametric analyses we examined the impact of COVID-19 on distress, measured by the Brief Symptom Inventory, in a sample of 4670 adolescents.\n\nOur results showed that the association between the COVID-19 impact and psychological distress in adolescents' lives was positive and moderate in Morocco and Serbia, positive and weak in Vietnam and the United States of America, and negative and weak in Sweden. We also found that female adolescents reported higher distress levels than male adolescents.\n\nCOVID-19 impacted adolescents and their psychological distress differently depending on their residence.", "doi": "10.3390/ijerph19148261", "pmid": "35886118", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19148261"}, {"db": "pmc", "key": "PMC9317312"}], "notes": [], "created": "2022-08-12T08:36:15.802Z", "modified": "2022-08-12T08:36:15.959Z"}, {"entity": "publication", "iuid": "5f8f810d6ce14398a6309fbb26311dca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f8f810d6ce14398a6309fbb26311dca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f8f810d6ce14398a6309fbb26311dca"}}, "title": "Fighting social isolation in times of pandemic COVID-19: the role of video calls for older hospitalized patients.", "authors": [{"family": "D\u00fcrst", "given": "Anne-V\u00e9ronique", "initials": "AV"}, {"family": "Graf", "given": "Christophe E", "initials": "CE"}, {"family": "Ruggiero", "given": "Carmelinda", "initials": "C"}, {"family": "Zekry", "given": "Dina", "initials": "D"}, {"family": "Boccardi", "given": "Virginia", "initials": "V"}, {"family": "Monney", "given": "Lauretta", "initials": "L"}, {"family": "Joss", "given": "Isaline", "initials": "I"}, {"family": "Vuilloud", "given": "Karine", "initials": "K"}, {"family": "Vespignani", "given": "Giulia", "initials": "G"}, {"family": "Bosshard", "given": "Wanda", "initials": "W"}, {"family": "Mecocci", "given": "Patrizia", "initials": "P"}, {"family": "Bula", "given": "Christophe J", "initials": "CJ"}, {"family": "D'Amelio", "given": "Patrizia", "initials": "P", "orcid": "0000-0002-4467-8337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c9b0d8ed88f48339d678ee72467a97d.json"}}], "type": "journal article", "published": "2022-07-06", "journal": {"title": "Aging Clin Exp Res", "issn": "1720-8319", "issn-l": "1594-0667"}, "abstract": "Loneliness and social isolation are associated with anxiety and psychological discomfort, especially amongst the oldest and fragile persons.\n\nSILVER evaluates the acceptance of video calls by old hospitalized patients and their relatives during the ban on visits due to the COVID-19. Moreover, SILVER evaluates if the use of different communication technology is associated with different outcomes in terms of anxiety, fear of self and of others' death and mood.\n\nSILVER is an observational multicentre study. Patients hospitalized in two geriatric units in Switzerland and in one orthogeriatric unit in Italy and their relatives were enrolled. Participants can freely choose to use phone or video calls and were evaluated over a week. We measured anxiety, fear of death and mood at baseline and at the end of the study with standard scales. The use of video or phone calls was associated to a change in these parameters by two-way ANOVA for repeated measures.\n\nSixty-four patients and relatives were enrolled, 26.5% used phone calls and 73.5% video calls. The use of video calls was associated with a reduction in anxiety and fear of death in patients and relatives as compared to participants using phone calls.\n\nOld patients and their relatives accepted and appreciated the use of video calls during hospitalization; moreover, participant using video calls appears to be less anxious and less afraid of death.\n\nVideo calls may be a useful communication tool for hospitalized older patients to keep social relationships with relatives and reduce their anxiety and fear of death.\n\nRetrospectively registered on 1st September 2021 in ClinicalTrials.gov (NCT05000099).", "doi": "10.1007/s40520-022-02188-8", "pmid": "35794314", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40520-022-02188-8"}, {"db": "pmc", "key": "PMC9261146"}, {"db": "ClinicalTrials.gov", "key": "NCT05000099"}], "notes": [], "created": "2022-08-17T10:47:20.389Z", "modified": "2022-08-17T10:47:20.446Z"}, {"entity": "publication", "iuid": "9f28d971c8194812a6292e5c9980d210", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f28d971c8194812a6292e5c9980d210.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f28d971c8194812a6292e5c9980d210"}}, "title": "Experiences of How Health and Lifestyle among Individuals with Knee Pain Have Been Influenced during the COVID-19 Pandemic, a HALLOA Study.", "authors": [{"family": "Sunesson", "given": "Evelina", "initials": "E"}, {"family": "Sylwander", "given": "Charlotte", "initials": "C"}, {"family": "Haglund", "given": "Emma", "initials": "E"}, {"family": "Andersson", "given": "Maria L E", "initials": "MLE", "orcid": "0000-0002-0217-5029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c44d890721546b4b14925b6cc9dc805.json"}}, {"family": "Larsson", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-4341-660X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65ac6fdb68864c928da7f0ad3f2d8b8d.json"}}], "type": "journal article", "published": "2022-07-06", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "14", "issn-l": null}, "abstract": "The COVID-19 pandemic has affected the health and lifestyles of both the general population and of vulnerable groups. Individuals with knee pain are recommended to lead an active lifestyle to relieve pain but find it difficult to maintain health and lifestyle compared to the general population due to the cause of chronic pain, impaired physical function, and a diminished quality of life. This study aimed to explore experiences of how health and lifestyle among individuals with knee pain have been influenced during the COVID-19 pandemic. Interviews (n = 19) were conducted in 2021 and analysed with qualitative content analysis. The results showed how individuals with knee pain adjusted their behaviour and revalued their life to maintain health and lifestyle during COVID-19. Adjusted behaviours emerged, such as spending more time at home, becoming digital, and spending more time outdoors, while revaluing life emerged as having a positive outlook on life and sharing responsibility. In conclusion, behaviour was adjusted, and life revalued to manage health and lifestyle during the pandemic. However, the findings are probably similar to the general population, i.e., individuals with knee pain live similar lives as the general population despite knee pain. The results may contribute to alternative ways of maintaining health and lifestyle in various vulnerable groups and may be applied in situations other than the pandemic.", "doi": "10.3390/ijerph19148255", "pmid": "35886110", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19148255"}, {"db": "pmc", "key": "PMC9315972"}], "notes": [], "created": "2022-08-12T08:36:38.200Z", "modified": "2022-08-12T08:36:38.309Z"}, {"entity": "publication", "iuid": "fcf104220f5242e1a52824105e8f0c05", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fcf104220f5242e1a52824105e8f0c05.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fcf104220f5242e1a52824105e8f0c05"}}, "title": "Dengue Infection - Recent Advances in Disease Pathogenesis in the Era of COVID-19.", "authors": [{"family": "Yong", "given": "Yean Kong", "initials": "YK"}, {"family": "Wong", "given": "Won Fen", "initials": "WF"}, {"family": "Vignesh", "given": "Ramachandran", "initials": "R"}, {"family": "Chattopadhyay", "given": "Indranil", "initials": "I"}, {"family": "Velu", "given": "Vijayakumar", "initials": "V"}, {"family": "Tan", "given": "Hong Yien", "initials": "HY"}, {"family": "Zhang", "given": "Ying", "initials": "Y"}, {"family": "Larsson", "given": "Marie", "initials": "M"}, {"family": "Shankar", "given": "Esaki M", "initials": "EM"}], "type": "journal article", "published": "2022-07-06", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "13", "pages": "889196", "issn-l": "1664-3224"}, "abstract": "The dynamics of host-virus interactions, and impairment of the host's immune surveillance by dengue virus (DENV) serotypes largely remain ambiguous. Several experimental and preclinical studies have demonstrated how the virus brings about severe disease by activating immune cells and other key elements of the inflammatory cascade. Plasmablasts are activated during primary and secondary infections, and play a determinative role in severe dengue. The cross-reactivity of DENV immune responses with other flaviviruses can have implications both for cross-protection and severity of disease. The consequences of a cross-reactivity between DENV and anti-SARS-CoV-2 responses are highly relevant in endemic areas. Here, we review the latest progress in the understanding of dengue immunopathogenesis and provide suggestions to the development of target strategies against dengue.", "doi": "10.3389/fimmu.2022.889196", "pmid": "35874775", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC9299105"}], "notes": [], "created": "2022-08-12T08:39:51.534Z", "modified": "2023-06-19T15:34:07.885Z"}, {"entity": "publication", "iuid": "94bdb76111d34f3f9a8895e350216a9a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/94bdb76111d34f3f9a8895e350216a9a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/94bdb76111d34f3f9a8895e350216a9a"}}, "title": "Comparison of drug prescribing before and during the COVID-19 pandemic: A cross-national European study.", "authors": [{"family": "Selke Krulichov\u00e1", "given": "Iva", "initials": "I", "orcid": "0000-0002-6815-0780", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b42258b4310445be9971d83f1863460e.json"}}, {"family": "Selke", "given": "Gisbert W", "initials": "GW", "orcid": "0000-0002-9614-9875", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4960af9c72b4042b9ec3dcd3436d1b2.json"}}, {"family": "Bennie", "given": "Marion", "initials": "M", "orcid": "0000-0002-4046-629X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d920bb014a2414b8171cc8b88abee31.json"}}, {"family": "Hajiebrahimi", "given": "Mohammadhossein", "initials": "M", "orcid": "0000-0001-8118-4988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8338602bdf4d40ffb25713e73b1fc719.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "F\u00fcrst", "given": "Jurij", "initials": "J"}, {"family": "Garuolien\u0117", "given": "Kristina", "initials": "K", "orcid": "0000-0001-7910-0108", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d0b8225059ef405383282d4d9cf02a2d.json"}}, {"family": "Poluzzi", "given": "Elisabetta", "initials": "E", "orcid": "0000-0002-7209-0426", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74229bb087504277a7d2befc7def7291.json"}}, {"family": "Slab\u00fd", "given": "Juraj", "initials": "J"}, {"family": "Yahni", "given": "Corinne Zara", "initials": "CZ", "orcid": "0000-0002-6831-2233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3118450a58744b3e9088d8d2ceb88c66.json"}}, {"family": "Altini", "given": "Mattia", "initials": "M", "orcid": "0000-0002-1809-184X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fdda0cf8e1e741a6be5c7e574d2de956.json"}}, {"family": "Fantini", "given": "Maria Pia", "initials": "MP", "orcid": "0000-0002-3257-6552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2dc69b69cb434e8ea5b7cb2a9267b6f2.json"}}, {"family": "Ko\u010d\u00ed", "given": "V\u00e1clav", "initials": "V"}, {"family": "McTaggart", "given": "Stuart", "initials": "S", "orcid": "0000-0001-6060-9019", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5502fb30f15c465bb0301428f8a0e2ef.json"}}, {"family": "Pontes", "given": "Caridad", "initials": "C", "orcid": "0000-0002-3274-6048", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bb9e906d55141a58f1379cfa81843cf.json"}}, {"family": "Reno", "given": "Chiara", "initials": "C", "orcid": "0000-0002-7933-2141", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9d5f681fdbe4057b795a9a0e73fe282.json"}}, {"family": "Rosa", "given": "Simona", "initials": "S"}, {"family": "Pedrola", "given": "Marta Turu", "initials": "MT", "orcid": "0000-0001-6957-3155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b0ea18522e843ca954888de7cfff1c2.json"}}, {"family": "Udovi\u010d", "given": "Mitja", "initials": "M"}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0003-0531-2516", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4911f8524d634e928a77f67c40e1610d.json"}}], "type": "journal article", "published": "2022-07-06", "journal": {"title": "Pharmacoepidemiol Drug Saf", "issn": "1099-1557", "issn-l": null}, "abstract": "The COVID-19 pandemic had an impact on health care, with disruption to routine clinical care. Our aim was to describe changes in prescription drugs dispensing in the primary and outpatient sectors during the first year of the pandemic across Europe.\n\nWe used routine administrative data on dispensed medicines in eight European countries (five whole countries, three represented by one region each) from January 2017 to March 2021 to compare the first year of the COVID-19 pandemic with the preceding 3 years.\n\nIn the 10 therapeutic subgroups with the highest dispensed volumes across all countries/regions the relative changes between the COVID-19 period and the year before were mostly of a magnitude similar to changes between previous periods. However, for drugs for obstructive airway diseases the changes in the COVID-19 period were stronger in several countries/regions. In all countries/regions a decrease in dispensed DDDs of antibiotics for systemic use (from -39.4% in Romagna to -14.2% in Scotland) and nasal preparations (from -34.4% in Lithuania to -5.7% in Sweden) was observed. We observed a stockpiling effect in the total market in March 2020 in six countries/regions. In Czechia the observed increase was not significant and in Slovenia volumes increased only after the end of the first lockdown. We found an increase in average therapeutic quantity per pack dispensed, which, however, exceeded 5% only in Slovenia, Germany, and Czechia.\n\nThe findings from this first European cross-national comparison show a substantial decrease in dispensed volumes of antibiotics for systemic use in all countries/regions. The results also indicate that the provision of medicines for common chronic conditions was mostly resilient to challenges faced during the pandemic. However, there were notable differences between the countries/regions for some therapeutic areas.", "doi": "10.1002/pds.5509", "pmid": "35791700", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9350215"}], "notes": [], "created": "2022-08-17T10:47:43.816Z", "modified": "2022-08-17T10:47:44.287Z"}, {"entity": "publication", "iuid": "97a4619db82b4311bbd564a3a54b3cd5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/97a4619db82b4311bbd564a3a54b3cd5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/97a4619db82b4311bbd564a3a54b3cd5"}}, "title": "Scandinavian Nurses' Use of Social Media during the COVID-19 Pandemic-A Berger and Luckman Inspired Analysis of a Qualitative Interview Study.", "authors": [{"family": "Glasdam", "given": "Stinne", "initials": "S", "orcid": "0000-0002-0893-3054", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c56787745d04e05ad85e53ce8df6061.json"}}, {"family": "Jacobsen", "given": "Frode F", "initials": "FF"}, {"family": "Hybholt", "given": "Lisbeth", "initials": "L", "orcid": "0000-0002-9764-8940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11f4283601794ccd903ead36c41ce8a3.json"}}, {"family": "Stjernsw\u00e4rd", "given": "Sigrid", "initials": "S", "orcid": "0000-0002-7152-9206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cda8ee3ae8564252aa6ffe2ab219ada8.json"}}], "type": "journal article", "published": "2022-07-05", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "volume": "10", "issue": "7", "issn-l": null}, "abstract": "There is a knowledge gap about nurses' use of social media in relation to and during the COVID-19 pandemic, which demands the upholding of a physical distance to other people, including patients and their relatives. The study aims to explore how nurses in the Scandinavian countries used social media for professional purposes in relation to the first 15 months of the COVID-19 pandemic. Qualitative, semi-structured interviews with 30 nurses in three Scandinavian countries (Denmark, Norway, and Sweden) were conducted. Thematic analyses were made, methodically inspired by Braun and Clarke, and theoretically inspired by Berger and Luckmann's theory about the construction of social reality. The Standards for Reporting Qualitative Research (SRQR) checklist was used. The results showed that social media was a socialisation tool for establishing new routines in clinical practice. Virtual meeting places supported collective understandings of a specific COVID-19 'reality' and 'knowledge' amongst nurses, with the pandemic bringing to the fore the issue of e-professionalism among nurses relating to their clinical practice. However, social media and virtual education were not commonly used in patient contacts. Further, nurses attempted a re-socialisation of the public to proper COVID-19 behaviour through social media. Moreover, blurred boundaries between acting as a private individual and a professional nurse were identified, where ethics of the nursing profession extended to nurses' private lives.", "doi": "10.3390/healthcare10071254", "pmid": "35885781", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "healthcare10071254"}, {"db": "pmc", "key": "PMC9321788"}], "notes": [], "created": "2022-08-12T08:36:58.308Z", "modified": "2022-08-12T08:37:41.053Z"}, {"entity": "publication", "iuid": "1a8b450f998f4242836f0c0e674bfd5c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1a8b450f998f4242836f0c0e674bfd5c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1a8b450f998f4242836f0c0e674bfd5c"}}, "title": "Impact of the COVID-19 pandemic on hernia surgery in a Swedish healthcare region: a population-based cohort study.", "authors": [{"family": "Kollatos", "given": "Christos", "initials": "C", "orcid": "0000-0001-5601-1794", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0c0f32a7ddd4310a7f83271538c234f.json"}}, {"family": "Hanna", "given": "Sarmad", "initials": "S"}, {"family": "Sandblom", "given": "Gabriel", "initials": "G"}], "type": "journal article", "published": "2022-07-05", "journal": {"title": "BMC Surg", "issn": "1471-2482", "volume": "22", "issue": "1", "pages": "260", "issn-l": null}, "abstract": "Swedish healthcare has been reorganised during the COVID-19 pandemic, affecting the availability of surgery for benign conditions. The aim of this study was to determine the effects of COVID-19 on emergency and elective hernia surgery in a Swedish healthcare region.\n\nUsing procedure codes, data from inguinal and ventral hernia procedures performed at the three hospitals in J\u00f6nk\u00f6ping Region, Sweden, from March 1st 2019 to January 31st 2021, were retrieved from a medical database. The cohort was divided into two groups: the COVID-19 group (March 1st 2020-January 31st 2021) and the control group (March 1st 2019-January 31st 2020). Demographic and preoperative data, hernia type, perioperative findings, and type of surgery were analysed.\n\nA total 1329 patients underwent hernia surgery during the study period; 579 were operated during the COVID-19 period and 750 during the control period. The number of emergency ventral hernia repairs increased during the COVID-19 period, but no difference in inguinal hernia repair rate was seen. The characteristics of patients that underwent hernia repair were similar in the two groups. Moreover, the decrease in elective ventral hernia repair rate during the COVID-19 period did not result in a higher risk for strangulation.\n\nThere is no evidence to suggest that the decrease in the number of elective ventral hernia repairs during the COVID-19 period had any impact on the risk for strangulation. Indications for surgery in patients with a symptomatic ventral or inguinal hernia should be carefully evaluated. Studies with greater power and longer follow-up are needed to gain a full understanding of the effects of the COVID-19 pandemic on hernia surgery.", "doi": "10.1186/s12893-022-01698-6", "pmid": "35790926", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12893-022-01698-6"}, {"db": "pmc", "key": "PMC9255440"}], "notes": [], "created": "2022-08-17T13:07:46.085Z", "modified": "2022-08-17T13:08:18.855Z"}, {"entity": "publication", "iuid": "4b3303eb8cc34f53b1dfd91a3ae8dda9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b3303eb8cc34f53b1dfd91a3ae8dda9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b3303eb8cc34f53b1dfd91a3ae8dda9"}}, "title": "Highly perturbed genes and hub genes associated with type 2 diabetes in different tissues of adult humans: a bioinformatics analytic workflow.", "authors": [{"family": "De Silva", "given": "Kushan", "initials": "K"}, {"family": "Demmer", "given": "Ryan T", "initials": "RT"}, {"family": "J\u00f6nsson", "given": "Daniel", "initials": "D"}, {"family": "Mousa", "given": "Aya", "initials": "A"}, {"family": "Forbes", "given": "Andrew", "initials": "A"}, {"family": "Enticott", "given": "Joanne", "initials": "J"}], "type": "journal article", "published": "2022-07-05", "journal": {"title": "Funct Integr Genomics", "issn": "1438-7948", "issn-l": null}, "abstract": "Type 2 diabetes (T2D) has a complex etiology which is not yet fully elucidated. The identification of gene perturbations and hub genes of T2D may deepen our understanding of its genetic basis. We aimed to identify highly perturbed genes and hub genes associated with T2D via an extensive bioinformatics analytic workflow consisting of five steps: systematic review of Gene Expression Omnibus and associated literature; identification and classification of differentially expressed genes (DEGs); identification of highly perturbed genes via meta-analysis; identification of hub genes via network analysis; and downstream analysis of highly perturbed genes and hub genes. Three meta-analytic strategies, random effects model, vote-counting approach, and p value combining approach, were applied. Hub genes were defined as those nodes having above-average betweenness, closeness, and degree in the network. Downstream analyses included gene ontologies, Kyoto Encyclopedia of Genes and Genomes pathways, metabolomics, COVID-19-related gene sets, and Genotype-Tissue Expression profiles. Analysis of 27 eligible microarrays identified 6284 DEGs (4592 downregulated and 1692 upregulated) in four tissue types. Tissue-specific gene expression was significantly greater than tissue non-specific (shared) gene expression. Analyses revealed 79 highly perturbed genes and 28 hub genes. Downstream analyses identified enrichments of shared genes with certain other diabetes phenotypes; insulin synthesis and action-related pathways and metabolomics; mechanistic associations with apoptosis and immunity-related pathways; COVID-19-related gene sets; and cell types demonstrating over- and under-expression of marker genes of T2D. Our approach provided valuable insights on T2D pathogenesis and pathophysiological manifestations. Broader utility of this pipeline beyond T2D is envisaged.", "doi": "10.1007/s10142-022-00881-5", "pmid": "35788821", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10142-022-00881-5"}, {"db": "pmc", "key": "PMC9255467"}], "notes": [], "created": "2022-08-17T13:09:22.836Z", "modified": "2022-08-17T13:09:50.558Z"}, {"entity": "publication", "iuid": "eb17fcce8461418a8c60d3476e72b39f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb17fcce8461418a8c60d3476e72b39f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb17fcce8461418a8c60d3476e72b39f"}}, "title": "Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency.", "authors": [{"family": "Campbell", "given": "Tessa Mollie", "initials": "TM", "orcid": "0000-0002-7737-2123", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8acc313f985d4822bf652289f0eb1b22.json"}}, {"family": "Liu", "given": "Zhiyong", "initials": "Z", "orcid": "0000-0001-6473-348X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d7b2869a5874679b1b6fdccade088a2.json"}}, {"family": "Zhang", "given": "Qian", "initials": "Q", "orcid": "0000-0002-9040-3289", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/341c0cb0fa7d41448e55344c82d68358.json"}}, {"family": "Moncada-Velez", "given": "Marcela", "initials": "M", "orcid": "0000-0002-3073-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c543a8539a6430b8ff5cd9cf5875bf9.json"}}, {"family": "Covill", "given": "Laura E", "initials": "LE", "orcid": "0000-0002-5086-9877", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12f826545b264c1d855a84c5fc3b73bd.json"}}, {"family": "Zhang", "given": "Peng", "initials": "P", "orcid": "0000-0002-6129-567X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ff2f497bd7841b7994dbdf8d2369a4e.json"}}, {"family": "Alavi Darazam", "given": "Ilad", "initials": "I", "orcid": "0000-0002-4440-335X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e747bb463d434cc8b586845f4609391e.json"}}, {"family": "Bastard", "given": "Paul", "initials": "P", "orcid": "0000-0002-5926-8437", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e3388c840d04a25824530a9bf999f01.json"}}, {"family": "Bizien", "given": "Lucy", "initials": "L", "orcid": "0000-0001-9163-9122", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ffde5891cfed41db9dc0265155576cc4.json"}}, {"family": "Bucciol", "given": "Giorgia", "initials": "G", "orcid": "0000-0001-5004-0738", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fde316a981d84407a32dca71fd6f39ba.json"}}, {"family": "Lind Enoksson", "given": "Sara", "initials": "S", "orcid": "0000-0002-0359-8824", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59b33d03efb841f89d3aa2d89618ff6c.json"}}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E"}, {"family": "Karabela", "given": "\u015eemsi Nur", "initials": "\u015eN", "orcid": "0000-0002-7358-9157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c50d261245743539a5813daffcaab72.json"}}, {"family": "Khan", "given": "Taushif", "initials": "T", "orcid": "0000-0002-7917-8965", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b38d5757c43448c3bf12179d4daaf6c2.json"}}, {"family": "Kendir-Demirkol", "given": "Yasemin", "initials": "Y", "orcid": "0000-0003-2562-3004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a31edf9803d748fea64cfd524f2cfe45.json"}}, {"family": "Arias", "given": "Andres Augusto", "initials": "AA", "orcid": "0000-0002-9478-8403", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd8725e3260449938376f721b1202424.json"}}, {"family": "Mansouri", "given": "Davood", "initials": "D", "orcid": "0000-0002-0564-8282", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5bd15b582b93449aaf4dc5cf76428ae9.json"}}, {"family": "Marits", "given": "Per", "initials": "P", "orcid": "0000-0003-2439-5687", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11e1e104844f49e3acadd1c573578941.json"}}, {"family": "Marr", "given": "Nico", "initials": "N", "orcid": "0000-0002-1927-7072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6b7acf92c1041aca93130dc97b1d2f8.json"}}, {"family": "Migeotte", "given": "Isabelle", "initials": "I", "orcid": "0000-0002-8972-8211", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43cd209fd75647fcbe0bd85bc8b94b19.json"}}, {"family": "Moens", "given": "Leen", "initials": "L", "orcid": "0000-0002-5347-6526", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49147a953e1c4721bd0181e5d0a3dafb.json"}}, {"family": "Ozcelik", "given": "Tayfun", "initials": "T", "orcid": "0000-0001-5937-1082", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6665d35db77044aa847a5f394332bb86.json"}}, {"family": "Pellier", "given": "Isabelle", "initials": "I", "orcid": "0000-0002-7988-4712", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/da3596d83f504628a6f4d86150486cbe.json"}}, {"family": "Sendel", "given": "Anton", "initials": "A", "orcid": "0000-0003-4410-3418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e1d9e27c0334858b83da8fdeeac0f9b.json"}}, {"family": "Shahrooei", "given": "Mohammad", "initials": "M", "orcid": "0000-0002-4974-3441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/165bdcfd868e4bd6b7adf371b9d4124f.json"}}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE", "orcid": "0000-0003-1907-3392", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26a3bf24bd044fbda8ffa0c89974bdfe.json"}}, {"family": "Vandernoot", "given": "Isabelle", "initials": "I", "orcid": "0000-0001-8084-7858", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b424cad4625b4b1eb4d901e206f0aa72.json"}}, {"family": "Willekens", "given": "Karen", "initials": "K", "orcid": "0000-0003-2338-5778", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/946e9a2c438f46f5ac816e827c5d8248.json"}}, {"family": "COVID Human Genetic Effort", "given": "", "initials": ""}, {"family": "Bergman", "given": "Peter", "initials": "P", "orcid": "0000-0003-3306-3713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15b7290255814a7b9a1a97c3cdb2fc26.json"}}, {"family": "Abel", "given": "Laurent", "initials": "L", "orcid": "0000-0001-7016-6493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fd6c4593c8c492a8dad8e49cb7a832a.json"}}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5369fe152ac94b5a81d4f913d85940a7.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL", "orcid": "0000-0002-7782-4169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1aca66ab7c39465faf2de03fa8a6722f.json"}}, {"family": "Meyts", "given": "Isabelle", "initials": "I", "orcid": "0000-0003-1214-0302", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a5399449f4c4d338b683632944008fb.json"}}, {"family": "Bryceson", "given": "Yenan T", "initials": "YT", "orcid": "0000-0002-7783-9934", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e66a62e856374a029c8446e863894afe.json"}}], "type": "journal article", "published": "2022-07-04", "journal": {"title": "J Exp Med", "issn": "1540-9538", "volume": "219", "issue": "7", "issn-l": null}, "abstract": "Autosomal recessive IRF7 deficiency was previously reported in three patients with single critical influenza or COVID-19 pneumonia episodes. The patients' fibroblasts and plasmacytoid dendritic cells produced no detectable type I and III IFNs, except IFN-\u03b2. Having discovered four new patients, we describe the genetic, immunological, and clinical features of seven IRF7-deficient patients from six families and five ancestries. Five were homozygous and two were compound heterozygous for IRF7 variants. Patients typically had one episode of pulmonary viral disease. Age at onset was surprisingly broad, from 6 mo to 50 yr (mean age 29 yr). The respiratory viruses implicated included SARS-CoV-2, influenza virus, respiratory syncytial virus, and adenovirus. Serological analyses indicated previous infections with many common viruses. Cellular analyses revealed strong antiviral immunity and expanded populations of influenza- and SARS-CoV-2-specific memory CD4+ and CD8+ T cells. IRF7-deficient individuals are prone to viral infections of the respiratory tract but are otherwise healthy, potentially due to residual IFN-\u03b2 and compensatory adaptive immunity.", "doi": "10.1084/jem.20220202", "pmid": "35670811", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "213267"}], "notes": [], "created": "2022-06-20T19:32:16.154Z", "modified": "2022-06-20T19:32:16.705Z"}, {"entity": "publication", "iuid": "69969fa1ecae46f88d17372796e6b72c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69969fa1ecae46f88d17372796e6b72c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69969fa1ecae46f88d17372796e6b72c"}}, "title": "A qualitative study on mothers' experiences attending an online infant massage class: \"It is funny! I feel close to my baby!\"", "authors": [{"family": "Khuzaiyah", "given": "Siti", "initials": "S"}, {"family": "Adnani", "given": "Qorinah Estiningtyas Sakilah", "initials": "QES"}, {"family": "Chabibah", "given": "Nur", "initials": "N"}, {"family": "Khanifah", "given": "Milatun", "initials": "M"}, {"family": "Lee", "given": "Ka Yiu", "initials": "KY"}], "type": "journal article", "published": "2022-07-04", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "volume": "21", "issue": "1", "pages": "175", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic impacts maternal and perinatal health. Fear of COVID-19 transmission may lead to psychological disorders among mothers, such as anxiety and depression, which might affect the infant's health. Innovation is needed to address problems related to this condition. This study aimed to explore the experiences of mothers who had attended online infant massage classes. METHODS: This qualitative survey recruited 12 Indonesian mothers who had infants aged < 12 months and joined the online infant massage class. An open-ended question form was used to collect data, which were analyzed using thematic content analysis.\n\nThere were six themes related to the experiences of mothers attending online infant massage classes: favorite session, new knowledge and skills, benefits, barriers during infant massage class, factors related to infant massage practice, and mother's hope.\n\nMothers had a good experience learning infant massage and had better interaction with their infants after the class. The findings show that an online infant massage class could benefit both mothers and infants.", "doi": "10.1186/s12912-022-00952-9", "pmid": "35787698", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12912-022-00952-9"}, {"db": "pmc", "key": "PMC9251925"}], "notes": [], "created": "2022-08-17T13:10:25.816Z", "modified": "2022-08-17T13:11:04.406Z"}, {"entity": "publication", "iuid": "689945ec3e6e417d9ef5a3de0de8f486", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/689945ec3e6e417d9ef5a3de0de8f486.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/689945ec3e6e417d9ef5a3de0de8f486"}}, "title": "The Effect of the COVID-19 Pandemic in Intestinal Rehabilitation and Transplant Patients: Initial Results of the Intestinal Rehabilitation and Transplant Association's International Survey.", "authors": [{"family": "Segovia", "given": "Maria", "initials": "M"}, {"family": "Fernandez", "given": "Maria Florencia", "initials": "MF"}, {"family": "Rumbo", "given": "Carolina", "initials": "C"}, {"family": "Zanfi", "given": "Chiara", "initials": "C"}, {"family": "Herlenius", "given": "Gustaf", "initials": "G"}, {"family": "Testro", "given": "Adam", "initials": "A"}, {"family": "Sharkey", "given": "Lisa", "initials": "L"}, {"family": "Braun", "given": "Felix", "initials": "F"}, {"family": "Jafri", "given": "Syed-Mohammed", "initials": "SM"}, {"family": "Vilca Melendez", "given": "Hector", "initials": "H"}, {"family": "Sanchez Claria", "given": "Rodrigo", "initials": "R"}, {"family": "Ceulemans", "given": "Laurens J", "initials": "LJ"}, {"family": "Hibi", "given": "Taizo", "initials": "T"}, {"family": "Solar", "given": "Hector", "initials": "H"}, {"family": "Ramisch", "given": "Diego", "initials": "D"}, {"family": "Noel", "given": "Gillian", "initials": "G"}, {"family": "Yap", "given": "Jason", "initials": "J"}, {"family": "Dijkstra", "given": "Gerard", "initials": "G"}, {"family": "Schiano", "given": "Thomas", "initials": "T"}, {"family": "Friend", "given": "Peter", "initials": "P"}, {"family": "Lacaille", "given": "Florence", "initials": "F"}, {"family": "Sudan", "given": "Debra", "initials": "D"}, {"family": "Mazariegos", "given": "George", "initials": "G"}, {"family": "Horslen", "given": "Simon", "initials": "S"}, {"family": "Gondolesi", "given": "Gabriel E", "initials": "GE"}], "type": "journal article", "published": "2022-07-01", "journal": {"title": "Transplantation", "issn": "1534-6080", "volume": "106", "issue": "7", "pages": "1289-1292", "issn-l": null}, "abstract": null, "doi": "10.1097/TP.0000000000004112", "pmid": "35731148", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00007890-202207000-00001"}, {"db": "pmc", "key": "PMC9213053"}], "notes": [], "created": "2022-08-17T13:06:38.928Z", "modified": "2022-08-17T13:06:38.942Z"}, {"entity": "publication", "iuid": "0eaabc4df5484e08b432df99ba66bab0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0eaabc4df5484e08b432df99ba66bab0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0eaabc4df5484e08b432df99ba66bab0"}}, "title": "Postacute elevation of D-dimer levels in severe acute respiratory syndrome coronavirus 2-positive nonhospitalized patients with mild symptoms.", "authors": [{"family": "Folkman", "given": "Rebecca", "initials": "R"}, {"family": "Kamal", "given": "Habiba", "initials": "H"}, {"family": "Ahl", "given": "Marcus", "initials": "M"}, {"family": "Szum", "given": "Adrian", "initials": "A"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Aleman", "given": "Soo", "initials": "S"}], "type": "journal article", "published": "2022-07-01", "journal": {"title": "Blood Coagul Fibrinolysis", "issn": "1473-5733", "volume": "33", "issue": "5", "pages": "285-287", "issn-l": null}, "abstract": null, "doi": "10.1097/MBC.0000000000001111", "pmid": "35703244", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00001721-990000000-00001"}], "notes": [], "created": "2022-08-17T12:59:42.144Z", "modified": "2022-08-17T13:00:05.206Z"}, {"entity": "publication", "iuid": "8f5a89f6b1bb484b8c9ddef1e8e7ec67", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f5a89f6b1bb484b8c9ddef1e8e7ec67.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f5a89f6b1bb484b8c9ddef1e8e7ec67"}}, "title": "Multidomain interventions for risk reduction and prevention of cognitive decline and dementia: current developments.", "authors": [{"family": "R\u00f6hr", "given": "Susanne", "initials": "S"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Mangialasche", "given": "Francesca", "initials": "F"}, {"family": "Ngandu", "given": "Tiia", "initials": "T"}, {"family": "Riedel-Heller", "given": "Steffi G", "initials": "SG"}], "type": "journal article", "published": "2022-07-01", "journal": {"title": "Curr Opin Psychiatry", "issn": "1473-6578", "volume": "35", "issue": "4", "pages": "285-292", "issn-l": null}, "abstract": "The potential for dementia prevention is deemed substantial if modifiable risk factors were addressed. First large-scale multidomain lifestyle interventions aiming at reducing risk of cognitive decline and dementia have yielded mixed but promising evidence.\n\nDespite the impact of the COVID-19 pandemic on trials conduction, causing interruptions and delays, the research landscape on multidomain interventions is growing rapidly. The successful Finish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) has led to an adaptation of the FINGER model in trials underway or being planned in over 40 countries. Recent studies identified barriers and facilitators of and adherence to multidomain interventions, showed the suitability of dementia risk scores as surrogate outcomes, and suggested mechanisms. Multidomain interventions are increasingly conducted in the Global South, and study protocols are increasingly testing expanded FINGER models, for example, with pharmacological components, in digital/remote settings and co-designed personalized interventions.\n\nThough results remain mixed, the many ongoing trials will provide more conclusive evidence within the next few years and help to optimize interventions. Continued international collaboration is pivotal to scale and accelerate the development and implementation of effective multidomain interventions as part of larger public health strategies to counteract the global dementia increase.", "doi": "10.1097/YCO.0000000000000792", "pmid": "35703256", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "00001504-990000000-00006"}], "notes": [], "created": "2022-06-20T18:11:52.181Z", "modified": "2022-08-17T12:58:51.225Z"}, {"entity": "publication", "iuid": "bc0b2685b3d34c29bfaf77ecbad868dc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bc0b2685b3d34c29bfaf77ecbad868dc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bc0b2685b3d34c29bfaf77ecbad868dc"}}, "title": "Management of Long COVID-The CoviMouv' Pilot Study: Importance of Adapted Physical Activity for Prolonged Symptoms Following SARS-CoV2 Infection.", "authors": [{"family": "Colas", "given": "Claire", "initials": "C"}, {"family": "Bayle", "given": "Manon", "initials": "M"}, {"family": "Labeix", "given": "Pierre", "initials": "P"}, {"family": "Botelho-Nevers", "given": "Elisabeth", "initials": "E"}, {"family": "Gagneux-Brunon", "given": "Amandine", "initials": "A"}, {"family": "Cazorla", "given": "C\u00e9line", "initials": "C"}, {"family": "Schein", "given": "Flora", "initials": "F"}, {"family": "Breugnon", "given": "Emma", "initials": "E"}, {"family": "Garcin", "given": "Arnauld", "initials": "A"}, {"family": "Feasson", "given": "L\u00e9onard", "initials": "L"}, {"family": "Roche", "given": "Fr\u00e9d\u00e9ric", "initials": "F"}, {"family": "Hupin", "given": "David", "initials": "D"}], "type": "journal article", "published": "2022-07-01", "journal": {"title": "Front Sports Act Living", "issn": "2624-9367", "volume": "4", "pages": "877188", "issn-l": null}, "abstract": "After a COVID-19 infection, some patients have persistent symptoms, the most common is fatigue. To prevent it from becoming chronic (post-COVID-19 syndrome), early management before 3 months could be useful. Exercise and education are recommended.\n\nTo assess fatigue in patients with prolonged symptoms after COVID-19 infection and who received a mixed program of remote adapted physical activity and therapeutic education. The secondary objective was to evaluate the efficacy and safety of this training method thanks to aerobic and anaerobic parameters.\n\n\"CoviMouv': From Coaching in Visual to Mouv in real\" is a nonrandomized controlled pilot study. Patients in telerehabilitation followed 12 remote exercise sessions and 3 therapeutic education workshops. Patients on traditional rehabilitation followed their program with a community-based physiotherapist.\n\nFatigue was reduced after the one-month intervention in both groups (p = 0.010). The majority of aerobic parameters were significantly improved, e.g., maximal oxygen uptake (p = 0.005), walking distance (p = 0.019) or hyperventilation values (p = 0.035). The anaerobic parameter was not improved (p = 0.400). No adverse event was declared.\n\nTelerehabilitation is a good alternative when a face-to-face program is not possible. This care at an early stage of the disease could help prevent the chronicity of post-COVID-19 symptoms and the installation of vicious circles of physical deconditioning. A larger study would be necessary.", "doi": "10.3389/fspor.2022.877188", "pmid": "35847457", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9283867"}], "notes": [], "created": "2022-08-12T08:52:50.981Z", "modified": "2022-08-12T08:52:50.987Z"}, {"entity": "publication", "iuid": "e82f7989e13243b19c9ab5812b957407", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e82f7989e13243b19c9ab5812b957407.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e82f7989e13243b19c9ab5812b957407"}}, "title": "Decision support-tools for early detection of infection in older people (aged> 65 years): a scoping review.", "authors": [{"family": "Masot", "given": "Olga", "initials": "O"}, {"family": "Cox", "given": "Anna", "initials": "A"}, {"family": "Mold", "given": "Freda", "initials": "F"}, {"family": "Sund-Levander", "given": "M\u00e4rtha", "initials": "M"}, {"family": "Tingstr\u00f6m", "given": "Pia", "initials": "P"}, {"family": "Boersema", "given": "Geertien Christelle", "initials": "GC"}, {"family": "Botigu\u00e9", "given": "Teresa", "initials": "T"}, {"family": "Daltrey", "given": "Julie", "initials": "J"}, {"family": "Hughes", "given": "Karen", "initials": "K"}, {"family": "Mayhorn", "given": "Christopher B", "initials": "CB"}, {"family": "Montgomery", "given": "Amy", "initials": "A"}, {"family": "Mullan", "given": "Judy", "initials": "J"}, {"family": "Carey", "given": "Nicola", "initials": "N"}], "type": "journal article", "published": "2022-07-01", "journal": {"title": "BMC Geriatr", "issn": "1471-2318", "volume": "22", "issue": "1", "pages": "552", "issn-l": null}, "abstract": "Infection is more frequent, and serious in people aged > 65 as they experience non-specific signs and symptoms delaying diagnosis and prompt treatment. Monitoring signs and symptoms using decision support tools (DST) is one approach that could help improve early detection ensuring timely treatment and effective care.\n\nTo identify and analyse decision support tools available to support detection of infection in older people (> 65 years).\n\nA scoping review of the literature 2010-2021 following Arksey and O'Malley (2005) framework and PRISMA-ScR guidelines. A search of MEDLINE, Cochrane, EMBASE, PubMed, CINAHL, Scopus and PsycINFO using terms to identify decision support tools for detection of infection in people > 65 years was conducted, supplemented with manual searches.\n\nSeventeen papers, reporting varying stages of development of different DSTs were analysed. DSTs largely focussed on specific types of infection i.e. urine, respiratory, sepsis and were frequently hospital based (n = 9) for use by physicians. Four DSTs had been developed in nursing homes and one a care home, two of which explored detection of non- specific infection.\n\nDSTs provide an opportunity to ensure a consistent approach to early detection of infection supporting prompt action and treatment, thus avoiding emergency hospital admissions. A lack of consideration regarding their implementation in practice means that any attempt to create an optimal validated and tested DST for infection detection will be impeded. This absence may ultimately affect the ability of the workforce to provide more effective and timely care, particularly during the current covid-19 pandemic.", "doi": "10.1186/s12877-022-03218-w", "pmid": "35778707", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12877-022-03218-w"}, {"db": "pmc", "key": "PMC9247966"}], "notes": [], "created": "2022-08-17T13:12:07.701Z", "modified": "2022-08-17T13:12:07.714Z"}, {"entity": "publication", "iuid": "17f887a93df245fbb3c3380cb298d54e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/17f887a93df245fbb3c3380cb298d54e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/17f887a93df245fbb3c3380cb298d54e"}}, "title": "Chemistry of Protein-Phenolic Interactions Toward the Microbiota and Microbial Infections.", "authors": [{"family": "Yilmaz", "given": "Hilal", "initials": "H"}, {"family": "Gultekin Subasi", "given": "Busra", "initials": "B"}, {"family": "Celebioglu", "given": "Hasan Ufuk", "initials": "HU"}, {"family": "Ozdal", "given": "Tugba", "initials": "T"}, {"family": "Capanoglu", "given": "Esra", "initials": "E"}], "type": "journal article", "published": "2022-07-01", "journal": {"title": "Front Nutr", "issn": "2296-861X", "volume": "9", "pages": "914118", "issn-l": null}, "abstract": "Along with health concerns, interest in plants as food and bioactive phytochemical sources has been increased in the last few decades. Phytochemicals as secondary plant metabolites have been the subject of many studies in different fields. Breakthrough for research interest on this topic is re-juvenilized with rising relevance in this global pandemics' era. The recent COVID-19 pandemic attracted the attention of people to viral infections and molecular mechanisms behind these infections. Thus, the core of the present review is the interaction of plant phytochemicals with proteins as these interactions can affect the functions of co-existing proteins, especially focusing on microbial proteins. To the best of our knowledge, there is no work covering the protein-phenolic interactions based on their effects on microbiota and microbial infections. The present review collects and defines the recent data, representing the interactions of phenolic compounds -primarily flavonoids and phenolic acids- with various proteins and explores how these molecular-level interactions account for the human health directly and/or indirectly, such as increased antioxidant properties and antimicrobial capabilities. Furthermore, it provides an insight about the further biological activities of interacted protein-phenolic structure from an antiviral activity perspective. The research on the protein-phenolic interaction mechanisms is of great value for guiding how to take advantage of synergistic effects of proteins and polyphenolics for future medical and nutritive approaches and related technologies.", "doi": "10.3389/fnut.2022.914118", "pmid": "35845785", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC9284217"}], "notes": [], "created": "2022-08-12T08:53:09.405Z", "modified": "2022-08-12T08:53:27.220Z"}, {"entity": "publication", "iuid": "87681bb5e6364fdc9e6084741f69928e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87681bb5e6364fdc9e6084741f69928e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87681bb5e6364fdc9e6084741f69928e"}}, "title": "A rapid assessment of take-home naloxone provision during COVID-19 in Europe.", "authors": [{"family": "McDonald", "given": "Rebecca", "initials": "R"}, {"family": "Eide", "given": "Desiree", "initials": "D"}, {"family": "Abel-Ollo", "given": "Katri", "initials": "K"}, {"family": "Barnsdale", "given": "Lee", "initials": "L"}, {"family": "Carter", "given": "Ben", "initials": "B"}, {"family": "Clausen", "given": "Thomas", "initials": "T"}, {"family": "Day", "given": "Ed", "initials": "E"}, {"family": "Fonseca", "given": "Francina", "initials": "F"}, {"family": "Holm\u00e9n", "given": "Elin", "initials": "E"}, {"family": "Horsburgh", "given": "Kirsten", "initials": "K"}, {"family": "Kelleher", "given": "Mike", "initials": "M"}, {"family": "K\u00e5berg", "given": "Martin", "initials": "M"}, {"family": "Ladenhauf", "given": "Martin", "initials": "M"}, {"family": "McAuley", "given": "Andrew", "initials": "A"}, {"family": "Metrebian", "given": "Nicola", "initials": "N"}, {"family": "Neale", "given": "Joanne", "initials": "J"}, {"family": "Parkin", "given": "Stephen", "initials": "S"}, {"family": "Ratcliffe", "given": "Kevin", "initials": "K"}, {"family": "Rintoul", "given": "Chris", "initials": "C"}, {"family": "Smith", "given": "Josie", "initials": "J"}, {"family": "Stifanoviciute", "given": "Viktorija", "initials": "V"}, {"family": "Torrens", "given": "Marta", "initials": "M"}, {"family": "Thiesen", "given": "Henrik", "initials": "H"}, {"family": "Strang", "given": "John", "initials": "J"}], "type": "journal article", "published": "2022-07-01", "journal": {"title": "Int J Drug Policy", "issn": "1873-4758", "volume": "107", "pages": "103787", "issn-l": null}, "abstract": "In March 2020, the World Health Organization declared COVID-19 a global pandemic. In the following weeks, most European countries implemented national lockdowns to mitigate viral spread. Services for people who use drugs had to quickly revise their operating procedures to rearrange service provision while adhering to lockdown requirements. Given the scarcity of literature published on overdose prevention during COVID-19 in Europe, we aimed to examine how these changes to service provision affected take-home naloxone (THN) programmes and naloxone availability across Europe.\n\nBetween November 2020 and January 2021, we conducted a rapid assessment with country experts from European countries that provide THN. We sent country experts a template to report monthly THN distribution data (January 1, 2019-October 31, 2020) and a structured 6-item survey for completion.\n\nResponses were received from 14 of the 15 European countries with THN provision of which 11 participated in the rapid assessment: Austria, Denmark, England, Estonia, Lithuania, Northern Ireland, Norway, Scotland, Spain (Catalonia only), Sweden, and Wales. All reported reduced organisational capacity during COVID-19, and some put into place a range of novel approaches to manage the restrictions on face-to-face service provision. In six countries, the introduction of programme innovation occurred alongside the publication of government guidelines recommending increased THN provision during COVID-19. Eight of the eleven participating countries managed to maintain 2019-level monthly THN distribution rates or even increase provision during the pandemic.\n\nThrough programme innovation supported by public guidelines, many European THN programmes managed to ensure stable or even increased THN provision during the pandemic, despite social distancing and stay-at-home orders affecting client mobility.", "doi": "10.1016/j.drugpo.2022.103787", "pmid": "35849935", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0955-3959(22)00202-X"}, {"db": "pmc", "key": "PMC9247228"}], "notes": [], "created": "2022-08-12T08:52:12.188Z", "modified": "2022-08-12T08:52:12.218Z"}, {"entity": "publication", "iuid": "d56ed86be45b4b0693bf640956ac99e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d56ed86be45b4b0693bf640956ac99e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d56ed86be45b4b0693bf640956ac99e1"}}, "title": "Treatment seeking for alcohol-related issues during the COVID-19 pandemic: An analysis of an addiction-specialized psychiatric treatment facility.", "authors": [{"family": "Andersson", "given": "Mitchell J", "initials": "MJ"}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": "8", "issue": "7", "pages": "e09934", "issn-l": null}, "abstract": "The COVID-19 pandemic and its societal impact may cause long-term behavioral changes in alcohol use due to increased psychological distress, unemployment, and time spent home. The purpose of this study was to determine whether or not the COVID-19 pandemic had a significant impact on treatment seeking for alcohol use disorders and related problems in a Swedish psychiatric treatment facility. Using an interrupted-time-series design on data derived from an addiction-specific psychiatric treatment facility located in Malm\u00f6, Sweden, we hypothesized that treatment seeking would decrease during the pandemic based on previous research identifying limited alcohol availability and affordability, as well as accessibility to treatment centers as influential factors. In addition, we assessed the predictive power of alcohol sales and number of active cases in the region using simple linear regressions. Results indicated that the pandemic had little to no effect on the number of people needing care, however a significant step change was found in treatment seeking patterns for unique female patients during the second wave (October 2020). Regression analyses indicated that alcohol sales and the number of active cases in the region did not significantly predict treatment seeking. A causal relationship between the onset of the pandemic and variation in treatment seeking for alcohol use could not be established. More research is needed to fully understand the pandemic's impact on alcohol use behavior change.", "doi": "10.1016/j.heliyon.2022.e09934", "pmid": "35855398", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(22)01222-1"}, {"db": "pmc", "key": "PMC9279183"}], "notes": [], "created": "2022-08-12T08:48:53.757Z", "modified": "2022-08-12T08:48:53.762Z"}, {"entity": "publication", "iuid": "2d232ef960984198bc09259d47b6c316", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d232ef960984198bc09259d47b6c316.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d232ef960984198bc09259d47b6c316"}}, "title": "Repurposing of antiviral drugs for COVID-19 and impact of repurposed drugs on the nervous system.", "authors": [{"family": "Punekar", "given": "Madhura", "initials": "M"}, {"family": "Kshirsagar", "given": "Manas", "initials": "M"}, {"family": "Tellapragada", "given": "Chaitanya", "initials": "C"}, {"family": "Patil", "given": "Kanchankumar", "initials": "K"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Microb Pathog", "issn": "1096-1208", "volume": "168", "pages": "105608", "issn-l": null}, "abstract": "The recent pandemic, Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has devastated humanity and is continuing to threaten us. Due to the high transmissibility of this pathogen, researchers are still trying to cope with the treatment and prevention of this disease. Few of them were successful in finding cure for COVID-19 by including repurposed drugs in the treatment. In such pandemic situations, when it is nearly impossible to design and implement a new drug target, previously designed antiviral drugs could help against novel viruses, referred to as drug repurposing/redirecting/repositioning or re-profiling. This review describes the current landscape of the repurposing of antiviral drugs for COVID-19 and the impact of these drugs on our nervous system. In some cases, specific antiviral therapy has been notably associated with neurological toxicity, characterized by peripheral neuropathy, neurocognitive and neuropsychiatric effects within the central nervous system (CNS).", "doi": "10.1016/j.micpath.2022.105608", "pmid": "35654381", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0882-4010(22)00221-2"}], "notes": [], "created": "2022-06-21T17:21:10.384Z", "modified": "2022-06-21T17:21:10.420Z"}, {"entity": "publication", "iuid": "f59339d3ad1844a095d84107b01f0f97", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f59339d3ad1844a095d84107b01f0f97.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f59339d3ad1844a095d84107b01f0f97"}}, "title": "Predicting attitudinal and behavioral responses to COVID-19 pandemic using machine learning.", "authors": [{"family": "Pavlovi\u0107", "given": "Tomislav", "initials": "T", "orcid": "0000-0002-4470-3715", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b5a5d7b53914f58ba60821e70539887.json"}}, {"family": "Azevedo", "given": "Flavio", "initials": "F", "orcid": "0000-0001-9000-8513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7864cb0e9bf846d6b69a6a5bf65cbd91.json"}}, {"family": "De", "given": "Koustav", "initials": "K", "orcid": "0000-0001-9562-0672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d6627eccf1d42baa44ed1ab89430f41.json"}}, {"family": "Ria\u00f1o-Moreno", "given": "Juli\u00e1n C", "initials": "JC", "orcid": "0000-0003-4182-0550", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/152a5f53020c49b8bac49dd90ac28253.json"}}, {"family": "Magli\u0107", "given": "Marina", "initials": "M", "orcid": "0000-0002-6851-4601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d8c351f3a484c3690ba0fa55f7cebdb.json"}}, {"family": "Gkinopoulos", "given": "Theofilos", "initials": "T", "orcid": "0000-0003-1070-6245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79f358d2d829449abfbcaee30042cc75.json"}}, {"family": "Donnelly-Kehoe", "given": "Patricio Andreas", "initials": "PA", "orcid": "0000-0002-3738-9537", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1477fc6c8a649d39e2f3f99d2580e95.json"}}, {"family": "Pay\u00e1n-G\u00f3mez", "given": "C\u00e9sar", "initials": "C", "orcid": "0000-0002-0633-1332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f473ea4639241fda23bf7f76ac9fef9.json"}}, {"family": "Huang", "given": "Guanxiong", "initials": "G", "orcid": "0000-0002-8588-1454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a1c0bc719e64cfb968124490fe30f56.json"}}, {"family": "Kantorowicz", "given": "Jaroslaw", "initials": "J", "orcid": "0000-0002-1186-5427", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/848df4a38f424410994e5c106185d6be.json"}}, {"family": "Birtel", "given": "Mich\u00e8le D", "initials": "MD", "orcid": "0000-0002-2383-9197", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d0e795d0cd4435586f09edfabffa510.json"}}, {"family": "Sch\u00f6negger", "given": "Philipp", "initials": "P", "orcid": "0000-0001-9930-487X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35568fb99a374c0a991a4be87eefa994.json"}}, {"family": "Capraro", "given": "Valerio", "initials": "V", "orcid": "0000-0002-0579-0166", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2eb7cac8bce492b93cf98134a322d4c.json"}}, {"family": "Santamar\u00eda-Garc\u00eda", "given": "Hernando", "initials": "H", "orcid": "0000-0001-9422-3579", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40b9f8cec76a4451862823b554f351c6.json"}}, {"family": "Yucel", "given": "Meltem", "initials": "M", "orcid": "0000-0002-7274-5971", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65a44c75ffa1499abea1909977b44e79.json"}}, {"family": "Ibanez", "given": "Agustin", "initials": "A", "orcid": "0000-0001-6758-5101", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4ec1841513243d981ba5cba471bc1d9.json"}}, {"family": "Rathje", "given": "Steve", "initials": "S", "orcid": "0000-0001-6727-571X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/358b4bc86edc4ff395946f7d420d28b8.json"}}, {"family": "Wetter", "given": "Erik", "initials": "E", "orcid": "0000-0002-5821-6651", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2fa438fa71224f4cb513cee60e632925.json"}}, {"family": "Stanojevi\u0107", "given": "Dragan", "initials": "D", "orcid": "0000-0002-3667-2461", "researcher": {"href": 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"initials": "Z", "orcid": "0000-0002-9231-5100", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/976f634ec7ff487a9e886500ff7f52ca.json"}}, {"family": "Mitkidis", "given": "Panagiotis", "initials": "P", "orcid": "0000-0002-9495-7369", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40b0c9405e1d4aef8a53e669fdb8847d.json"}}, {"family": "Cichocka", "given": "Aleksandra", "initials": "A", "orcid": "0000-0003-1703-1586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0cc1202c8fb34d07952c7d99ab43bf87.json"}}, {"family": "Gelfand", "given": "Michele", "initials": "M"}, {"family": "Alfano", "given": "Mark", "initials": "M", "orcid": "0000-0001-5879-8033", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9adf19b051647d19c86bc89ee440988.json"}}, {"family": "Ross", "given": "Robert M", "initials": "RM", "orcid": "0000-0001-8711-1675", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49cb2e4d713844729ee7d64213f3cdbe.json"}}, {"family": "Sj\u00e5stad", "given": "Hallgeir", "initials": "H", "orcid": "0000-0002-8730-1038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9d4b3d4379f4e3bb43607c0ef08f159.json"}}, {"family": "Nezlek", "given": "John B", "initials": "JB", "orcid": "0000-0003-4963-3637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab0b925a3d5b4c3d9f03d141757d41ba.json"}}, {"family": "Cislak", "given": "Aleksandra", "initials": "A", "orcid": "0000-0002-9880-6947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37e0b6640a76467890fed6a7975b031c.json"}}, {"family": "Lockwood", "given": "Patricia", "initials": "P", "orcid": "0000-0001-7195-9559", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d77d4779b0ff456b906f2001dc3aa36f.json"}}, {"family": "Abts", "given": "Koen", "initials": "K", "orcid": "0000-0001-8546-8347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9128fa7c6104fecabd5e4e52b1ce6ee.json"}}, {"family": "Agadullina", "given": "Elena", "initials": "E", "orcid": "0000-0002-1505-1412", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1d55ff13a5b4373abb3aca1376a41b9.json"}}, {"family": "Amodio", "given": "David M", "initials": "DM", "orcid": "0000-0001-7746-0150", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/909d9da1100b49cfb829c88277849da2.json"}}, {"family": "Apps", "given": "Matthew A J", "initials": "MAJ", "orcid": "0000-0001-5793-2202", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd23864c1da2420aab5bc56d02b7f770.json"}}, {"family": "Aruta", "given": "John Jamir Benzon", "initials": "JJB", "orcid": "0000-0003-4155-1063", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc1b14a0e89b4d9cb7f9c977e34a9a67.json"}}, {"family": "Besharati", "given": "Sahba", "initials": "S", "orcid": "0000-0003-2836-7982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8948fcda91f444f89cc8ddcfe4e489d9.json"}}, {"family": "Bor", "given": "Alexander", "initials": "A", "orcid": "0000-0002-2624-9221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/048bdb252beb4b2599b619f41ace6277.json"}}, {"family": "Choma", "given": "Becky", "initials": "B", "orcid": "0000-0002-8286-8983", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/207911cc2901427598e7b5f60bd927da.json"}}, {"family": "Cunningham", "given": "William", "initials": "W"}, {"family": "Ejaz", "given": "Waqas", "initials": "W", "orcid": "0000-0002-2492-4115", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0540fea51e3740068aa543e3e9bfd57e.json"}}, 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"orcid": "0000-0002-0794-7702", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8177b1e630c54506b665af61a4204f3c.json"}}, {"family": "Zwaan", "given": "Rolf A", "initials": "RA", "orcid": "0000-0001-9967-7879", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c6e9acd4b0c4c3881f364b11f0dc8d0.json"}}, {"family": "Boggio", "given": "Paulo Sergio", "initials": "PS", "orcid": "0000-0002-6109-0447", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1a661afdf824fa596f035139880c521.json"}}, {"family": "Whillans", "given": "Ashley", "initials": "A"}, {"family": "Van Lange", "given": "Paul A M", "initials": "PAM", "orcid": "0000-0001-7774-6984", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14e8d477999b4beb9878beb5f7ee3e99.json"}}, {"family": "Prasad", "given": "Rajib", "initials": "R", "orcid": "0000-0003-0913-1624", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22102152292941f183ae692ea2e24a2a.json"}}, {"family": "Onderco", "given": "Michal", "initials": "M", "orcid": "0000-0001-9911-3782", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeef609fb2c44af5b8f38042a590b931.json"}}, {"family": "O'Madagain", "given": "Cathal", "initials": "C", "orcid": "0000-0002-4086-524X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee7ab547d0f146929e7aece70f30cd24.json"}}, {"family": "Nesh-Nash", "given": "Tarik", "initials": "T", "orcid": "0000-0002-5532-9095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b8406427e494a16b95e8e3aebf40345.json"}}, {"family": "Laguna", "given": "Oscar Moreda", "initials": "OM"}, {"family": "Kubin", "given": "Emily", "initials": "E", "orcid": "0000-0003-0606-8594", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bf123de600e4b958365eb744b78825a.json"}}, {"family": "G\u00fcmren", "given": "Mert", "initials": "M", "orcid": "0000-0002-3298-6295", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46f817818fab49a18e8576bbe9775d11.json"}}, {"family": "Fenwick", "given": "Ali", "initials": "A", "orcid": "0000-0002-5412-9745", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f45980f8496c4d039e2bdbb71bdf7a8c.json"}}, {"family": "Ertan", "given": "Arhan S", "initials": "AS", "orcid": "0000-0001-9730-8391", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/459a43a3f47548c3a73d95dbba35127e.json"}}, {"family": "Bernstein", "given": "Michael J", "initials": "MJ", "orcid": "0000-0002-8083-9839", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12779a2d6b544bf994b765780cde0723.json"}}, {"family": "Amara", "given": "Hanane", "initials": "H", "orcid": "0000-0003-0732-2320", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88b038a62a4845d6a7f46f40071a8d42.json"}}, {"family": "Van Bavel", "given": "Jay Joseph", "initials": "JJ", "orcid": "0000-0002-2520-0442", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/344fbd5da7bc4259b3f70839f401c84c.json"}}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "PNAS Nexus", "issn": "2752-6542", "volume": "1", "issue": "3", "pages": "pgac093", "issn-l": null}, "abstract": "At the beginning of 2020, COVID-19 became a global problem. Despite all the efforts to emphasize the relevance of preventive measures, not everyone adhered to them. Thus, learning more about the characteristics determining attitudinal and behavioral responses to the pandemic is crucial to improving future interventions. In this study, we applied machine learning on the multinational data collected by the International Collaboration on the Social and Moral Psychology of COVID-19 (N = 51,404) to test the predictive efficacy of constructs from social, moral, cognitive, and personality psychology, as well as socio-demographic factors, in the attitudinal and behavioral responses to the pandemic. The results point to several valuable insights. Internalized moral identity provided the most consistent predictive contribution-individuals perceiving moral traits as central to their self-concept reported higher adherence to preventive measures. Similar results were found for morality as cooperation, symbolized moral identity, self-control, open-mindedness, and collective narcissism, while the inverse relationship was evident for the endorsement of conspiracy theories. However, we also found a non-neglible variability in the explained variance and predictive contributions with respect to macro-level factors such as the pandemic stage or cultural region. Overall, the results underscore the importance of morality-related and contextual factors in understanding adherence to public health recommendations during the pandemic.", "doi": "10.1093/pnasnexus/pgac093", "pmid": "35990802", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "pgac093"}, {"db": "pmc", "key": "PMC9381137"}], "notes": [], "created": "2022-09-12T18:51:19.761Z", "modified": "2022-09-12T18:51:22.853Z"}, {"entity": "publication", "iuid": "fa42143e23004ff695be370f9d78be58", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa42143e23004ff695be370f9d78be58.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa42143e23004ff695be370f9d78be58"}}, "title": "Living with the aftermaths of a stroke in the era of the COVID-19 pandemic; the significance of home and close surroundings.", "authors": [{"family": "Kyl\u00e9n", "given": "Maya", "initials": "M"}, {"family": "von Koch", "given": "Lena", "initials": "L"}, {"family": "Wottrich", "given": "Annica Wohlin", "initials": "AW"}, {"family": "Elf", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Health Place", "issn": "1873-2054", "volume": "76", "pages": "102852", "issn-l": null}, "abstract": "Stay-at-home recommendations to reduce the spread of the COVID-19 virus have had a major impact on people's everyday lives. However, while the evidence indicates that such recommendations have caused distress, anxiety, and fear among the public, little is known about how persons living with complex health conditions, e.g., disability after stroke, have experienced and handled the situation. We interviewed fourteen participants (7 women, 7 men) aged 61-91 years living in ordinary housing during summer 2020 to explore how people who recovered after a stroke experienced their everyday lives in their homes and close surroundings during the COVID-19 pandemic recommendations. Three intertwined themes were constructed from the narrative data and the iterative thematic analysis: (1) Places within and out of reach, (2) Upholding activities-strategies and structures, and (3) Adapting to new circumstances. The findings suggest that places within reach were important to maintain activities and provide structure in daily life. The participants seemed to make use of their previous experiences of adjusting to new circumstances after stroke when adapting to living under the stay-at-home recommendations. In addition, feeling that they now shared the restrictions with all other people in society seemed to ease their situations. Access to nature and spaces in the close surroundings was essential for staying socially connected and receiving support in daily life. The significance of the home and the neighbourhood for health experiences among people who recently have had a stroke should inform rehabilitation interventions both during and after pandemics and environmental planning.", "doi": "10.1016/j.healthplace.2022.102852", "pmid": "35803042", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1353-8292(22)00113-7"}, {"db": "pmc", "key": "PMC9222220"}], "notes": [], "created": "2022-08-17T10:44:25.664Z", "modified": "2022-08-17T10:44:36.090Z"}, {"entity": "publication", "iuid": "44c5299a78d54745b8e0de0df6e5aaa9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44c5299a78d54745b8e0de0df6e5aaa9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44c5299a78d54745b8e0de0df6e5aaa9"}}, "title": "Impacts of severity of Covid-19 infection on the morbidity and mortality of surgical patients.", "authors": [{"family": "Al Ani", "given": "Amer", "initials": "A"}, {"family": "Tahtamoni", "given": "Rafeef", "initials": "R"}, {"family": "Mohammad", "given": "Yara", "initials": "Y"}, {"family": "Al-Ayoubi", "given": "Fawzi", "initials": "F"}, {"family": "Haider", "given": "Nadeem", "initials": "N"}, {"family": "Al-Mashhadi", "given": "Ammar", "initials": "A"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Ann Med Surg (Lond)", "issn": "2049-0801", "pages": "103910", "volume": "79", "issn-l": null}, "abstract": "One of the challenges of surgery on patients with active SARS-CoV-2(severe acute respiratory syndrome coronavirus 2) infection is the increased risk of postoperative morbidity and mortality.\n\nThis study will describe and compare the postoperative morbidity and mortality in asymptomatic patients or those with mild infection with those with severe COVID-19 infection undergoing elective or and emergency surgery.\n\nThis is a retrospective study of 37 COVID19 patients who had the infection 7 days prior to and 30 days after emergency or elective surgery. Patients were divided to two groups. Group1: the asymptomatic or those with mild infection that is diagnosed just before surgery (14 patients). Group 2: those who were admitted to the hospital because of severe COVID-19 and were operated for COVID-19 related complications (23 patients). Morbidity and mortality of both groups was studied.\n\nThere was no significant difference in gender between the two groups. There were 5 females (2 in group 1, and 3 in group 2) and 32 males (12 in group 1, and 20 in group 2). Mean age for all patients was 49.8years (38 for group 1 and 57 for group2). Median age for all patients was 50 years (37.5 for group 1 and 57 years for group 2). Sepsis developed in 7 patients (1 patient in group 1 and in 6 patients in group 2). Statistically there was no significant difference in occurrence of sepsis between the two groups. There was a significant difference in the intensive care stay between the two groups (higher in group 2). Four deaths were reported in group 1 and fourteen in group 2. Eighteen out of thirty-seven patients died.\n\nSeverity of COVID-19 infection will prolong the hospitalization and ICU stay in surgical patients with no significant effect on mortality.", "doi": "10.1016/j.amsu.2022.103910", "pmid": "35698648", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2049-0801(22)00670-7"}, {"db": "pmc", "key": "PMC9176105"}], "notes": [], "created": "2022-06-20T18:16:44.976Z", "modified": "2022-08-17T13:02:53.070Z"}, {"entity": "publication", "iuid": "66a8f5b641e34e5e903816b561a944a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66a8f5b641e34e5e903816b561a944a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66a8f5b641e34e5e903816b561a944a1"}}, "title": "Immune responses after omicron infection in triple-vaccinated health-care workers with and without previous SARS-CoV-2 infection.", "authors": [{"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Norin", "given": "Nina Greilert", "initials": "NG"}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Garc\u00eda", "given": "Marina", "initials": "M"}, {"family": "Tecleab", "given": "Teghesti", "initials": "T"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Forsell", "given": "Mattias", "initials": "M"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "letter", "published": "2022-07-00", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "issn-l": null, "volume": "22", "issue": "7", "pages": "943-945"}, "abstract": null, "doi": "10.1016/S1473-3099(22)00362-0", "pmid": "35691303", "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9183210"}, {"db": "pii", "key": "S1473-3099(22)00362-0"}], "notes": [], "created": "2022-06-20T18:21:45.781Z", "modified": "2023-06-19T14:27:30.544Z"}, {"entity": "publication", "iuid": "4a9fbf6212c841cc8bc0ff99dfa7f18b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4a9fbf6212c841cc8bc0ff99dfa7f18b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4a9fbf6212c841cc8bc0ff99dfa7f18b"}}, "title": "Follow-up regimes for sick-listed employees: A comparison of nine north-western European countries.", "authors": [{"family": "Ose", "given": "Solveig Osborg", "initials": "SO"}, {"family": "Kaspersen", "given": "Silje Lill", "initials": "SL"}, {"family": "Leinonen", "given": "Taina", "initials": "T"}, {"family": "Verstappen", "given": "Suzanne", "initials": "S"}, {"family": "de Rijk", "given": "Angelique", "initials": "A"}, {"family": "Spasova", "given": "Slavina", "initials": "S"}, {"family": "Hultqvist", "given": "Sara", "initials": "S"}, {"family": "N\u00f8rup", "given": "Iben", "initials": "I"}, {"family": "P\u00e1lsson", "given": "J\u00f3n R", "initials": "JR"}, {"family": "Blume", "given": "Andreas", "initials": "A"}, {"family": "Paternoga", "given": "Mike", "initials": "M"}, {"family": "Kalseth", "given": "Jorid", "initials": "J"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Health Policy", "issn": "0168-8510", "volume": "126", "issue": "7", "pages": "619-631", "issn-l": null}, "abstract": "The Covid-19 pandemic has revealed the importance of social protection systems, including income security, when health problems arise. The aims of this study are to compare the follow-up regimes for sick-listed employees across nine European countries, and to conduct a qualitative assessment of the differences with respect to burden and responsibility sharing between the social protection system, employers and employees. The tendency highlighted is that countries with shorter employer periods of sick-pay typically have stricter follow-up responsibility for employers because, in practice, they become gatekeepers of the public sickness benefit scheme. In Germany and the UK, employers have few requirements for follow-up compared with the Nordic countries because they bear most of the costs of sickness absence themselves. The same applies in Iceland, where employers carry most of the costs and have no obligation to follow up sick-listed employees. The situation in the Netherlands is paradoxical: employers have strict obligations in the follow-up regime even though they cover all the costs of the sick-leave themselves. During the pandemic, the majority of countries have adjusted their sick-pay system and increased coverage to reduce the risk of spreading Covid-19 because employees are going to work sick or when they should self-quarantine, except for the Netherlands and Belgium, which considered that the current schemes were already sufficient to reduce that risk.", "doi": "10.1016/j.healthpol.2022.05.002", "pmid": "35577620", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0168-8510(22)00104-X"}, {"db": "pmc", "key": "PMC9085445"}], "notes": [], "created": "2022-06-21T18:05:44.262Z", "modified": "2022-06-21T18:05:45.486Z"}, {"entity": "publication", "iuid": "07ee362db00f4e4892091f0ed7f26e18", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07ee362db00f4e4892091f0ed7f26e18.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07ee362db00f4e4892091f0ed7f26e18"}}, "title": "Factors associated with clinical progression to severe COVID-19 in people with cystic fibrosis: A global observational study.", "authors": [{"family": "Carr", "given": "Siobh\u00e1n B", "initials": "SB"}, {"family": "McClenaghan", "given": "Elliot", "initials": "E"}, {"family": "Elbert", "given": "Alexander", "initials": "A"}, {"family": "Faro", "given": "Albert", "initials": "A"}, {"family": "Cosgriff", "given": "Rebecca", "initials": "R"}, {"family": "Abdrakhmanov", "given": "Olzhas", "initials": "O"}, {"family": "Brownlee", "given": "Keith", "initials": "K"}, {"family": "Burgel", "given": "Pierre-R\u00e9gis", "initials": "PR"}, {"family": "Byrnes", "given": "Catherine A", "initials": "CA"}, {"family": "Cheng", "given": "Stephanie Y", "initials": "SY"}, {"family": "Colombo", "given": "Carla", "initials": "C"}, {"family": "Corvol", "given": "Harriet", "initials": "H"}, {"family": "Daneau", "given": "G\u00e9raldine", "initials": "G"}, {"family": "Goss", "given": "Christopher H", "initials": "CH"}, {"family": "Gulmans", "given": "Vincent", "initials": "V"}, {"family": "Gutierrez", "given": "Hector", "initials": "H"}, {"family": "Harutyunyan", "given": "Satenik", "initials": "S"}, {"family": "Helmick", "given": "Meagan", "initials": "M"}, {"family": "Jung", "given": "Andreas", "initials": "A"}, {"family": "Kashirskaya", "given": "Nataliya", "initials": "N"}, {"family": "McKone", "given": "Edward", "initials": "E"}, {"family": "Melo", "given": "Joel", "initials": "J"}, {"family": "Middleton", "given": "Peter G", "initials": "PG"}, {"family": "Mondejar-Lopez", "given": "Pedro", "initials": "P"}, {"family": "de Monestrol", "given": "Isabelle", "initials": "I"}, {"family": "N\u00e4hrlich", "given": "Lutz", "initials": "L"}, {"family": "Padoan", "given": "Rita", "initials": "R"}, {"family": "Parker", "given": "Megan", "initials": "M"}, {"family": "Pastor-Vivero", "given": "M Dolores", "initials": "MD"}, {"family": "Rizvi", "given": "Samar", "initials": "S"}, {"family": "Ruseckaite", "given": "Rasa", "initials": "R"}, {"family": "Salvatore", "given": "Marco", "initials": "M"}, {"family": "da Silva-Filho", "given": "Luiz Vicente R F", "initials": "LVRF"}, {"family": "Versmessen", "given": "Nick", "initials": "N"}, {"family": "Zampoli", "given": "Marco", "initials": "M"}, {"family": "Marshall", "given": "Bruce C", "initials": "BC"}, {"family": "Stephenson", "given": "Anne L", "initials": "AL"}, {"family": "CF Registry Global Collaboration", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "J Cyst Fibros", "issn": "1873-5010", "volume": "21", "issue": "4", "pages": "e221-e231", "issn-l": null}, "abstract": "This international study aimed to characterise the impact of acute SARS-CoV-2 infection in people with cystic fibrosis and investigate factors associated with severe outcomes. Methods Data from 22 countries prior to 13th December 2020 and the introduction of vaccines were included. It was de-identified and included patient demographics, clinical characteristics, treatments, outcomes and sequalae following SARS-CoV-2 infection. Multivariable logistic regression was used to investigate factors associated with clinical progression to severe COVID-19, using the primary outcome of hospitalisation with supplemental oxygen.\n\nSARS-CoV-2 was reported in 1555 people with CF, 1452 were included in the analysis. One third were aged <18 years, and 9.4% were solid-organ transplant recipients. 74.5% were symptomatic and 22% were admitted to hospital. In the non-transplanted cohort, 39.5% of patients with ppFEV1<40% were hospitalised with oxygen verses 3.2% with ppFEV >70%: a 17-fold increase in odds. Worse outcomes were independently associated with older age, non-white race, underweight body mass index, and CF-related diabetes. Prescription of highly effective CFTR modulator therapies was associated with a significantly reduced odds of being hospitalised with oxygen (AOR 0.43 95%CI 0.31-0.60 p<0.001). Transplanted patients were hospitalised with supplemental oxygen therapy (21.9%) more often than non-transplanted (8.8%) and was independently associated with the primary outcome (Adjusted OR 2.45 95%CI 1.27-4.71 p=0.007).\n\nThis is the first study to show that there is a protective effect from the use of CFTR modulator therapy and that people with CF from an ethnic minority are at more risk of severe infection with SARS-CoV-2.", "doi": "10.1016/j.jcf.2022.06.006", "pmid": "35753987", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1569-1993(22)00593-8"}, {"db": "pmc", "key": "PMC9189103"}], "notes": [], "created": "2022-08-19T05:39:10.105Z", "modified": "2022-08-19T05:39:10.118Z"}, {"entity": "publication", "iuid": "2736ce22a4c84406aff2878bf7382293", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2736ce22a4c84406aff2878bf7382293.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2736ce22a4c84406aff2878bf7382293"}}, "title": "Evaluation of a pneumonia multiplex PCR panel for detection of bacterial respiratory tract pathogens from serial specimens collected from hospitalized COVID-19 patients.", "authors": [{"family": "Tellapragada", "given": "Chaitanya", "initials": "C"}, {"family": "Ydsten", "given": "Karin Andersson", "initials": "KA"}, {"family": "Ternhag", "given": "Anders", "initials": "A"}, {"family": "Giske", "given": "Christian G", "initials": "CG"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Eur J Clin Microbiol Infect Dis", "issn": "1435-4373", "volume": "41", "issue": "7", "pages": "1093-1098", "issn-l": null}, "abstract": "We investigated the concordance between the Unyvero Hospitalized Pneumonia (HPN) application and quantitative culture for detection of bacterial pathogens from serial lower respiratory tract (LRT) specimens collected from the same subject. Comparison of results from HPN application and culture was evaluated using 69 LRT samples from 27 subjects, using two evaluation approaches. False positive detections by the HPN application was 29% (20/69) in Evaluation I vs 10% (7/68) in Evaluation II. Additional pathogens detected by the HPN application could be confirmed in many instances by culture positivity for the same organism from previous or subsequent samples from the same subject.", "doi": "10.1007/s10096-022-04466-9", "pmid": "35727430", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10096-022-04466-9"}, {"db": "pmc", "key": "PMC9210330"}], "notes": [], "created": "2022-08-17T13:05:50.911Z", "modified": "2022-08-17T13:05:50.925Z"}, {"entity": "publication", "iuid": "6df11f853339494a86fd28b53ff34350", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6df11f853339494a86fd28b53ff34350.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6df11f853339494a86fd28b53ff34350"}}, "title": "Estimation of COVID-19 vaccine effectiveness against hospitalisation in individuals aged \u2265 65 years using electronic health registries; a pilot study in four EU/EEA countries, October 2021 to March 2022.", "authors": [{"family": "Sent\u00eds", "given": "Alexis", "initials": "A"}, {"family": "Kislaya", "given": "Irina", "initials": "I"}, {"family": "Nicolay", "given": "Nathalie", "initials": "N"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}, {"family": "Starrfelt", "given": "Jostein", "initials": "J"}, {"family": "Mart\u00ednez-Baz", "given": "Iv\u00e1n", "initials": "I"}, {"family": "Castilla", "given": "Jes\u00fas", "initials": "J"}, {"family": "Nielsen", "given": "Katrine Finderup", "initials": "KF"}, {"family": "Hansen", "given": "Christian Holm", "initials": "CH"}, {"family": "Emborg", "given": "Hanne-Dorthe", "initials": "HD"}, {"family": "Nardone", "given": "Anthony", "initials": "A"}, {"family": "Derrough", "given": "Tarik", "initials": "T"}, {"family": "Valenciano", "given": "Marta", "initials": "M"}, {"family": "Nunes", "given": "Baltazar", "initials": "B"}, {"family": "Monge", "given": "Susana", "initials": "S"}, {"family": "VEBIS-Lot4 working group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "27", "issue": "30", "issn-l": null}, "abstract": "By employing a common protocol and data from electronic health registries in Denmark, Navarre (Spain), Norway and Portugal, we estimated vaccine effectiveness (VE) against hospitalisation due to COVID-19 in individuals aged \u2265 65 years old, without previous documented infection, between October 2021 and March 2022. VE was higher in 65-79-year-olds compared with \u2265 80-year-olds and in those who received a booster compared with those who were primary vaccinated. VE remained high (ca 80%) between \u2265 12 and < 24 weeks after the first booster administration, and after Omicron became dominant.", "doi": "10.2807/1560-7917.ES.2022.27.30.2200551", "pmid": "35904059", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9336167"}], "notes": [], "created": "2022-08-12T08:31:50.769Z", "modified": "2022-08-12T08:31:50.775Z"}, {"entity": "publication", "iuid": "257be128e37140f4add47ae92431b41f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/257be128e37140f4add47ae92431b41f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/257be128e37140f4add47ae92431b41f"}}, "title": "Digital tools in allergy and respiratory care.", "authors": [{"family": "Verhoeven", "given": "Elisabeth", "initials": "E"}, {"family": "Rouadi", "given": "Philip", "initials": "P"}, {"family": "Jaoude", "given": "Eliane Abou", "initials": "EA"}, {"family": "Abouzakouk", "given": "Mohamed", "initials": "M"}, {"family": "Ansotegui", "given": "Ignacio", "initials": "I"}, {"family": "Al-Ahmad", "given": "Mona", "initials": "M"}, {"family": "Al-Nesf", "given": "Maryam Ali", "initials": "MA"}, {"family": "Azar", "given": "Cecilio", "initials": "C"}, {"family": "Bahna", "given": "Sami", "initials": "S"}, {"family": "Cuervo-Pardo", "given": "Lyda", "initials": "L"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}, {"family": "Douagui", "given": "Habib", "initials": "H"}, {"family": "Maximiliano G\u00f3mez", "given": "R", "initials": "R"}, {"family": "D\u00edaz", "given": "Sandra Gonz\u00e1lez", "initials": "SG"}, {"family": "Han", "given": "Joseph K", "initials": "JK"}, {"family": "Idriss", "given": "Samar", "initials": "S"}, {"family": "Irani", "given": "Carla", "initials": "C"}, {"family": "Karam", "given": "Marilyn", "initials": "M"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Nsouli", "given": "Talal", "initials": "T"}, {"family": "Scadding", "given": "Glenis", "initials": "G"}, {"family": "Senior", "given": "Brent", "initials": "B"}, {"family": "Smith", "given": "Pete", "initials": "P"}, {"family": "Y\u00e1\u00f1ez", "given": "Anah\u00ed", "initials": "A"}, {"family": "Zaitoun", "given": "Fares", "initials": "F"}, {"family": "Hellings", "given": "Peter W", "initials": "PW"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "World Allergy Organ J", "issn": "1939-4551", "volume": "15", "issue": "7", "pages": "100661", "issn-l": "1939-4551"}, "abstract": "Patient care in the allergy and respiratory fields is advancing rapidly, offering the possibility of the inclusion of a variety of digital tools that aim to improve outcomes of care. Impaired access to several health care facilities during the COVID-19 pandemic has considerably increased the appetite and need for the inclusion of e-health tools amongst end-users. Consequently, a multitude of different e-health tools have been launched worldwide with various registration and access options, and with a wide range of offered benefits. From the perspective of both patients and healthcare providers (HCPs), as well as from a legal and device-related perspective, several features are important for the acceptance, effectiveness,and long-term use of e-health tools. Patients and physicians have different needs and expectations of how digital tools might be of help in the care pathway. There is a need for standardization by defining quality assurance criteria. Therefore, the Upper Airway Diseases Committee of the World Allergy Organization (WAO) has taken the initiative to define and propose criteria for quality, appeal, and applicability of e-health tools in the allergy and respiratory care fields from a patient, clinician, and academic perspective with the ultimate aim to improve patient health and outcomes of care.", "doi": "10.1016/j.waojou.2022.100661", "pmid": "35784945", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1939-4551(22)00037-0"}, {"db": "pmc", "key": "PMC9243254"}], "notes": [], "created": "2022-08-17T13:10:51.707Z", "modified": "2022-08-17T13:10:51.720Z"}, {"entity": "publication", "iuid": "9cb40d5b1e9c472380fa0a51dd85c534", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9cb40d5b1e9c472380fa0a51dd85c534.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9cb40d5b1e9c472380fa0a51dd85c534"}}, "title": "Acute odynophagia: A new symptom of COVID-19 during the SARS-CoV-2 Omicron variant wave in Sweden.", "authors": [{"family": "Piersiala", "given": "Krzysztof", "initials": "K", "orcid": "0000-0003-3711-8371", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a8e2fbec7bb40ef8c1124526d3ac846.json"}}, {"family": "Kakabas", "given": "Lara", "initials": "L"}, {"family": "Bruckova", "given": "Anna", "initials": "A"}, {"family": "Starkhammar", "given": "Magnus", "initials": "M"}, {"family": "Cardell", "given": "Lars Olaf", "initials": "LO"}], "type": "case reports", "published": "2022-07-00", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": "292", "issue": "1", "pages": "154-161", "issn-l": null}, "abstract": "The objective of this study is to present a novel clinical manifestation of infection with the Omicron variant of the SARS-CoV-2 virus affecting mainly young, vaccinated, and healthy adults. We describe a new group of COVID-19 patients seeking emergency care with symptoms similar to the life-threatening condition epiglottitis. Here, we present a case series and discuss management.\n\nWe performed a retrospective single-center case study of patients diagnosed with COVID-19 who were referred to the Ear, Nose, and Throat Emergency Department (ENT ED) between January 1 and January 23, 2022 with clinical symptoms such as acute odynophagia, severe sore throat, and fever. Ethical approval was obtained from the Swedish Ethical Review Authority (2020-02579). Informed consent was obtained from all patients included in the study.\n\nTwenty patients meeting inclusion criteria were identified. Fifteen patients were fully vaccinated against COVID-19. Four patients needed a short hospitalization for their symptoms. The most common diagnoses were COVID-19-associated acute viral laryngotracheitis and/or viral pharyngitis. Six patients presented with signs of secondary bacterial infection and were put on antibiotics.\n\nPrevious variants of SARS-CoV-2 infection affected predominantly the lower respiratory tract and were associated with loss of smell and taste in many patients. The Omicron variant seems to affect predominantly the upper airways and cause acute laryngitis without olfactory dysfunction. In some patients, the clinical manifestation is similar to the symptoms of epiglottitis. In such a case, a prompt examination of the larynx is the gold standard to exclude inflammatory edema in the upper airways. None of the patients described in this study developed epiglottitis. In this study, we discuss the management of acute odynophagia in COVID-19 patients.", "doi": "10.1111/joim.13470", "pmid": "35170099", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Omicron VoC": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC9115132"}], "notes": [], "created": "2023-07-13T11:25:59.766Z", "modified": "2023-07-13T11:25:59.881Z"}, {"entity": "publication", "iuid": "b1afaead4b2549a896f087c73a1b5421", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1afaead4b2549a896f087c73a1b5421.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1afaead4b2549a896f087c73a1b5421"}}, "title": "A Qualitative Serial Analysis of Drawings by Thirteen-to Fifteen-Year-Old Adolescents in Sweden About the First Wave of the Covid-19 Pandemic.", "authors": [{"family": "Tishelman", "given": "Carol", "initials": "C", "orcid": "0000-0003-4161-0342", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1fbfdb57e5124e72bcffcce93b21fa05.json"}}, {"family": "Degen", "given": "Johanna L", "initials": "JL", "orcid": "0000-0002-0530-1385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c045049dcce40d8acc195b696cda010.json"}}, {"family": "Weiss Goitiand\u00eda", "given": "Sof\u00eda", "initials": "S", "orcid": "0000-0001-6538-0786", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5a80a546baf4241a238dd3850dbb9dc.json"}}, {"family": "Kleijberg", "given": "Max", "initials": "M", "orcid": "0000-0003-4036-707X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8087207bbaa34fdc896906ea11ada0fc.json"}}, {"family": "Kleeberg-Niepage", "given": "Andrea", "initials": "A", "orcid": "0000-0002-2433-8714", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fad2466bf73045b48d00493c9ea0ab4a.json"}}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Qual Health Res", "issn": "1049-7323", "pages": "1370-1385", "volume": "32", "issue": "8-9", "issn-l": null}, "abstract": "In this article, we explore the perspectives of 13-15-year-olds living in Sweden about the first wave of the Covid-19 pandemic, through inductive analysis of 187 of their drawings. Through reconstructive serial picture analysis, three types of meaning were derived: (1) A new normal in dystopian scenery points to the disruption of daily life and development of new praxis and meaning in a context of threat and restriction; (2) Disrupted relationships refers to these adolescents' self-portrayal as solitary, without adult guidance or friends prominent; and (3) Negative emotions and compliant behaviors addresses a range of negative emotions and expressions of loss with few proactive strategies illustrated. General existential distress appears in these drawings, seemingly compounded by both developmental stage and other factors in addition to the pandemic context. Drawings suggest a restricted repertoire of ways of dealing with challenges confronting these adolescents, who seemed to feel left to their own resources.", "doi": "10.1177/10497323221101978", "pmid": "35599585", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9350847"}], "notes": [], "created": "2022-06-21T17:58:05.053Z", "modified": "2023-01-13T14:48:28.475Z"}, {"entity": "publication", "iuid": "91af983740274e2e8242aa0949ed018e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/91af983740274e2e8242aa0949ed018e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/91af983740274e2e8242aa0949ed018e"}}, "title": "The Relationship between COVID-19 and Hypothalamic-Pituitary-Adrenal Axis: A Large Spectrum from Glucocorticoid Insufficiency to Excess-The CAPISCO International Expert Panel.", "authors": [{"family": "Jensterle", "given": "Mojca", "initials": "M", "orcid": "0000-0002-8861-8803", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59986ccac1b64e869ae0bd6761209852.json"}}, {"family": "Herman", "given": "Rok", "initials": "R", "orcid": "0000-0002-6053-5686", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff3ab4ee68944de5b693af679f9ca8df.json"}}, {"family": "Jane\u017e", "given": "Andrej", "initials": "A", "orcid": "0000-0002-6594-5254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43670b2197b8438e85feec7094864ce5.json"}}, {"family": "Mahmeed", "given": "Wael Al", "initials": "WA", "orcid": "0000-0003-0312-9910", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/263122e48a624950a78cfa8d0aca83bd.json"}}, {"family": "Al-Rasadi", "given": "Khalid", "initials": "K", "orcid": "0000-0003-0460-1236", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa65f0bc61f44c47860a15aa8b7eba15.json"}}, {"family": "Al-Alawi", "given": "Kamila", "initials": "K"}, {"family": "Banach", "given": "Maciej", "initials": "M"}, {"family": "Banerjee", "given": "Yajnavalka", "initials": "Y", "orcid": "0000-0002-7546-8893", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d8dea02972d4523816d940a6e0d2fb6.json"}}, {"family": "Ceriello", "given": "Antonio", "initials": "A"}, {"family": "Cesur", "given": "Mustafa", "initials": "M", "orcid": "0000-0002-1029-2604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b6591ae68a0442cfba8dbca9f28d9104.json"}}, {"family": "Cosentino", "given": "Francesco", "initials": "F"}, {"family": "Galia", "given": "Massimo", "initials": "M"}, {"family": "Goh", "given": "Su-Yen", "initials": "SY"}, {"family": "Kalra", "given": "Sanjay", "initials": "S"}, {"family": "Kempler", "given": "Peter", "initials": "P"}, {"family": "Lessan", "given": "Nader", "initials": "N", "orcid": "0000-0001-9147-0961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6fe7d1c124a4a349038f540cbf6721f.json"}}, {"family": "Lotufo", "given": "Paulo", "initials": "P"}, {"family": "Papanas", "given": "Nikolaos", "initials": "N", "orcid": "0000-0002-7320-785X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/540620683a4749568584a98e68dc73ed.json"}}, {"family": "Rizvi", "given": "Ali A", "initials": "AA", "orcid": "0000-0002-3714-0790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ab189188b8e4543aafa50f2422c70ea.json"}}, {"family": "Santos", "given": "Raul D", "initials": "RD"}, {"family": "Stoian", "given": "Anca P", "initials": "AP", "orcid": "0000-0003-0555-526X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0aef0cbf4cae4db68b4248baf9a8da4e.json"}}, {"family": "Toth", "given": "Peter P", "initials": "PP", "orcid": "0000-0001-5810-5460", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c17462263aef48dd8f61914bedb1a9a2.json"}}, {"family": "Viswanathan", "given": "Vijay", "initials": "V"}, {"family": "Rizzo", "given": "Manfredi", "initials": "M", "orcid": "0000-0002-9549-8504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d888593722ae4ba2b12a04effd67eaff.json"}}], "type": "journal article", "published": "2022-06-30", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "23", "issue": "13", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) is a highly heterogeneous disease regarding severity, vulnerability to infection due to comorbidities, and treatment approaches. The hypothalamic-pituitary-adrenal (HPA) axis has been identified as one of the most critical endocrine targets of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that might significantly impact outcomes after infection. Herein we review the rationale for glucocorticoid use in the setting of COVID-19 and emphasize the need to have a low index of suspicion for glucocorticoid-induced adrenal insufficiency, adjusting for the glucocorticoid formulation used, dose, treatment duration, and underlying health problems. We also address several additional mechanisms that may cause HPA axis dysfunction, including critical illness-related corticosteroid insufficiency, the direct cytopathic impacts of SARS-CoV-2 infection on the adrenals, pituitary, and hypothalamus, immune-mediated inflammations, small vessel vasculitis, microthrombotic events, the resistance of cortisol receptors, and impaired post-receptor signaling, as well as the dissociation of ACTH and cortisol regulation. We also discuss the increased risk of infection and more severe illness in COVID-19 patients with pre-existing disorders of the HPA axis, from insufficiency to excess. These insights into the complex regulation of the HPA axis reveal how well the body performs in its adaptive survival mechanism during a severe infection, such as SARS-CoV-2, and how many parameters might disbalance the outcomes of this adaptation.", "doi": "10.3390/ijms23137326", "pmid": "35806331", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijms23137326"}, {"db": "pmc", "key": "PMC9266848"}], "notes": [], "created": "2022-08-17T10:41:22.987Z", "modified": "2022-08-17T10:42:24.138Z"}, {"entity": "publication", "iuid": "01e843d52d084c7dbf5d8b9e20438faf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01e843d52d084c7dbf5d8b9e20438faf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01e843d52d084c7dbf5d8b9e20438faf"}}, "title": "Self-Assessed Aspects of Health 3 Months after COVID-19 Hospitalization-A Swedish Cross-Sectional Study.", "authors": [{"family": "Larsson", "given": "Alexandra C", "initials": "AC", "orcid": "0000-0001-9100-4071", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8532302825d744c7b29ccefeb16e11e2.json"}}, {"family": "Engwall", "given": "Marie", "initials": "M"}, {"family": "Palstam", "given": "Annie", "initials": "A", "orcid": "0000-0002-7127-213X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b127bce23f5545a5a17354e60b780f86.json"}}, {"family": "Persson", "given": "Hanna C", "initials": "HC", "orcid": "0000-0001-8633-3292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc8035c749ab4521b549ea820f6b4389.json"}}], "type": "journal article", "published": "2022-06-30", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "13", "issn-l": null}, "abstract": "It is not yet fully understood how the patients self-assess their overall health in the early recovery after COVID-19 and if certain patient groups are more prominent in perceived long-time effects of COVID-19. The aim of this study was to describe self-assessed aspects of health in body function, activity and participation 3 months after hospitalization due to COVID-19 and identify difference between groups depending in age, sex and level of hospital care. This cross-sectional study consists of self-assessed aspects of health and recovery in 168 participants (mean age 64 years old, 69% men) previously hospitalized patients due to COVID-19. We have previously published data, from hospital discharge, on this cohort were predominantly the older patients and previous ICU-treated participants were affected. In this study there were differences in between groups. Of the study population 72% perceived fatigue, 64% respiratory difficulties, 37% perceived symptoms of anxiety. Three-months after COVID-19 this cohort was overall still affected. The recovery process is multifaced and the cohort heterogeneous, hence the rehabilitation needs to be highly individualized, and the follow-up of this patient group is of importance regardless of age, sex and previous level of hospital care.", "doi": "10.3390/ijerph19138020", "pmid": "35805677", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19138020"}, {"db": "pmc", "key": "PMC9265939"}], "notes": [], "created": "2022-08-17T10:42:51.136Z", "modified": "2022-08-17T10:42:51.223Z"}, {"entity": "publication", "iuid": "4b1e5771831f45e5a86dff2c0d89c457", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b1e5771831f45e5a86dff2c0d89c457.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b1e5771831f45e5a86dff2c0d89c457"}}, "title": "Face mask-induced purpura: another unexpected effect of COVID era.", "authors": [{"family": "Piccolo", "given": "V", "initials": "V", "orcid": "0000-0001-7798-4368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1ddb3ce197e446dbc8156e8e3222d5e.json"}}, {"family": "Bassi", "given": "A", "initials": "A", "orcid": "0000-0002-9157-5189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2628d4790c0041b19e8bf037d259ed99.json"}}, {"family": "Mazzatenta", "given": "C", "initials": "C"}, {"family": "Russo", "given": "T", "initials": "T"}, {"family": "Argenziano", "given": "G", "initials": "G", "orcid": "0000-0003-1413-8214", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7fd2179bdb540a784d26cd05f39b77d.json"}}, {"family": "Cutrone", "given": "M", "initials": "M"}, {"family": "Danielsson Darlington", "given": "Markus Es", "initials": "ME"}, {"family": "Grimalt", "given": "R", "initials": "R", "orcid": "0000-0001-7204-8626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b47bbd772ef942cb87ee26fe24e0e0e7.json"}}], "type": "letter", "published": "2022-06-30", "journal": {"title": "J Eur Acad Dermatol Venereol", "issn": "1468-3083", "issn-l": null}, "abstract": null, "doi": "10.1111/jdv.18392", "pmid": "35771119", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9349894"}], "notes": [], "created": "2022-08-19T05:31:31.758Z", "modified": "2022-08-19T05:31:31.879Z"}, {"entity": "publication", "iuid": "5d844d0935554a7f8d3faadc2065998f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d844d0935554a7f8d3faadc2065998f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d844d0935554a7f8d3faadc2065998f"}}, "title": "Development of nurse-led videoconference-delivered cognitive behavioural therapy for domestic violence: Feasibility and acceptability.", "authors": [{"family": "Nesset", "given": "Merete Berg", "initials": "MB", "orcid": "0000-0003-4582-8349", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1fe1e4abc6f546ee8a1071eff3ae456f.json"}}, {"family": "Lauvrud", "given": "Christian", "initials": "C"}, {"family": "Meisingset", "given": "Anne", "initials": "A"}, {"family": "Nyhus", "given": "Eskil", "initials": "E"}, {"family": "Palmstierna", "given": "Tom", "initials": "T"}, {"family": "Lara-Cabrera", "given": "Mariela Loreto", "initials": "ML", "orcid": "0000-0002-7342-9049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bdee466c211435486b6f62b2940e473.json"}}], "type": "journal article", "published": "2022-06-30", "journal": {"title": "J Adv Nurs", "issn": "1365-2648", "issn-l": null}, "abstract": "Because of the COVID-19 lockdown, an internet-based adaption of a nurse-led cognitive behavioural group therapy (CGBT) was provided for perpetrators of domestic violence. The aim of this study was to describe the development of the therapy, examine the initial feasibility and impact on patient satisfaction of the programme and evaluate the associated patient-reported experiences.\n\nProgramme development as well as testing its feasibility and acceptability using cross-sectional survey data.\n\nAnonymous data were collected at a university hospital in Norway between October and December 2021. Feasibility was examined by comparing the numbers of patients who agreed to participate, chose not to participate or dropped out during the intervention. There was a self-reporting scale that evaluated patient satisfaction, and the participants were invited to make suggestions for improvement of the intervention. The results of the study are reported in accordance with the STROBE checklist.\n\nThe videoconference-delivered CGBT was feasible. Two of the 67 patients refused to attend therapy delivered in a remote manner (3.0%), and four patients (6.0%) were classified as non-completers. Overall, patients were satisfied with the therapy.\n\nThis study described a promising nurse-led internet-based intervention for individuals who were domestically violent and had voluntarily sought healthcare help. The participants' satisfaction with the intervention indicates its acceptability and feasibility. However, research on internet-based cognitive behaviour therapy is still in its infancy. These results may guide the future development of internet-based cognitive behavioural therapy (CBT) for individuals who perpetrate domestic violence. Further research is needed on the pros and cons of this mode of service delivery.\n\nThis study addressed the challenges of providing treatment for domestic violence during the COVID-19 pandemic by examining videoconference-delivered CBT for individuals who perpetrate domestic violence.", "doi": "10.1111/jan.15347", "pmid": "35774003", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-17T13:13:56.417Z", "modified": "2022-08-17T13:13:56.503Z"}, {"entity": "publication", "iuid": "23fd55e2b4e14e789737af66351eff51", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23fd55e2b4e14e789737af66351eff51.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23fd55e2b4e14e789737af66351eff51"}}, "title": "Development Work in Swedish Eldercare: Resources for Trustworthy, Integrated Managerial Work During the COVID-19 Pandemic.", "authors": [{"family": "Dellve", "given": "Lotta", "initials": "L"}, {"family": "Williamsson", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-06-30", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "10", "pages": "864272", "issn-l": "2296-2565"}, "abstract": "The extensive needs for developments of eldercare addressing working conditions, care quality, influence, and safety was highlighted during the pandemic. This mixed-method study contribute with knowledge about capability-strengthening development work and its importance for trustworthy managerial work, before and during the COVID-19 pandemic. Questionnaire data and narratives from first-line managers immediately before (n = 284) and 16 months into the pandemic (n = 189), structured interviews with development leaders (n = 25), and documents were analyzed. The results identify different focuses of development work. Strategic-level development leaders focused the strengthening of old adults' capabilities. While operational-level leaders approached strengthening employees' capability. First-line managers' rating of their trustworthy managerial work decreased during the pandemic and was associated with their workload, development support and capability-strengthening projects focusing employees' resources. The study demonstrates the gap between strategic and the operational levels regarding understanding of capability set and needed resources for strengthening capabilities and trustworthy, integrated managerial work regarding safety, influence, and quality conditions for old adults and employees.", "doi": "10.3389/fpubh.2022.864272", "pmid": "35844876", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9280882"}], "notes": [], "created": "2022-08-12T08:53:45.557Z", "modified": "2022-08-12T08:53:45.564Z"}, {"entity": "publication", "iuid": "c29c572267d64128b2d27af013aba852", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c29c572267d64128b2d27af013aba852.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c29c572267d64128b2d27af013aba852"}}, "title": "Mitochondrial dysfunction is associated with lipid metabolism disorder and upregulation of angiotensin-converting enzyme 2.", "authors": [{"family": "Zhao", "given": "Qian", "initials": "Q", "orcid": "0000-0001-9218-9506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd48776ed26440f9a727f785cbd98b38.json"}}, {"family": "Zhou", "given": "Xiaoshan", "initials": "X"}, {"family": "Kuiper", "given": "Raoul", "initials": "R"}, {"family": "Curbo", "given": "Sophie", "initials": "S"}, {"family": "Karlsson", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-06-29", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "6", "pages": "e0270418", "issn-l": "1932-6203"}, "abstract": "Thymidine kinase 2 (TK2) deficiency in humans leads to a myopathic form of mitochondrial DNA (mtDNA) deficiency. Here we present a skeletal and cardiac muscle specific TK2 knockout mouse (mTk2 KO). The mice showed dilated hearts and markedly reduced adipose tissue during week 12 to 16. A severe decrease of mtDNA was found only in skeletal muscle and heart tissue in mTk2 KO mice. Expression analysis of key metabolic genes of 16 weeks knockout mice showed significant changes of genes involved in lipid metabolism, with different patterns in heart and skeletal muscle. Our study further suggests that lipoprotein lipase (LPL) from liver supports the metabolism when heart and skeletal muscle were impaired due to mitochondrial dysfunction. The angiotensin-converting enzyme 2 (ACE2), which is involved in glucose homeostasis, was also affected by mtDNA deficiency in our study. Interestingly, both the gene and protein expression of ACE2 were increased in cardiac tissue of mTk2 KO mice. Since ACE2 is a receptor for the SARS-CoV-2 virus, its regulation in relation to mitochondrial function may have important clinical implications.", "doi": "10.1371/journal.pone.0270418", "pmid": "35767531", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-31565"}, {"db": "pmc", "key": "PMC9242481"}], "notes": [], "created": "2022-08-19T05:32:55.634Z", "modified": "2022-08-19T05:32:55.692Z"}, {"entity": "publication", "iuid": "c7ee9a93593848aea5b72f76cf9d6a2a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7ee9a93593848aea5b72f76cf9d6a2a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7ee9a93593848aea5b72f76cf9d6a2a"}}, "title": "Elementary School Teachers' Perceptions of COVID-19-Related Restrictions on Food Allergy Management.", "authors": [{"family": "Santos", "given": "Mae Jhelene L", "initials": "MJL"}, {"family": "Riediger", "given": "Natalie", "initials": "N", "orcid": "0000-0002-8736-9446", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc59a9c00b1b4d4cb2cbb391b115a789.json"}}, {"family": "Abrams", "given": "Elissa M", "initials": "EM"}, {"family": "Piquemal", "given": "Nathalie", "initials": "N"}, {"family": "Protudjer", "given": "Jennifer L P", "initials": "JLP", "orcid": "0000-0002-3888-8688", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e35d8fddae04acbb44382b43acb0147.json"}}], "type": "journal article", "published": "2022-06-29", "journal": {"title": "Nutrients", "issn": "2072-6643", "volume": "14", "issue": "13", "issn-l": null}, "abstract": "(1) Background: Approximately 7% of Canadian children live with a food allergy (FA). Pre-COVID-19, ~20% of anaphylactic reactions occurred in schools. Yet, teachers reported poor FA-related knowledge, and experiences during the COVID-19 pandemic are not well-studied. Additionally, teachers' management approaches vary widely. We aimed to describe elementary school teachers' perceptions about FA management during the COVID-19 pandemic; (2) Methods: Using a semi-structured interview guide, English-speaking elementary school teachers in Winnipeg, Canada were interviewed virtually. Interviews were audio-recorded and transcribed verbatim. Data were analysed thematically; (3) Results: Most teachers were female and taught in public schools. Two themes were identified. Theme 1, COVID-19 restrictions made mealtimes more manageable, capturing the positive impacts of pandemic restrictions such as seating arrangements and enhanced cleaning. Limited lunchtime supervision prompted some teachers to assume this role. Theme 2, Food allergy management was indirectly adapted to fit changing COVID-19 restrictions, describing how changing restrictions influenced FA-related practices. FA training was offered virtually with less nursing support. Class cohorts and remote learning decreased teachers' perceived risk and FA-related management responsibility; (4) Conclusions: COVID-19-related practices were perceived as positively influencing in-school FA management, although unintended consequences, such as increased supervisory roles for teachers and reduced nursing support, were described.", "doi": "10.3390/nu14132714", "pmid": "35807894", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "nu14132714"}, {"db": "pmc", "key": "PMC9268574"}], "notes": [], "created": "2022-08-17T10:41:54.202Z", "modified": "2022-08-17T10:42:02.391Z"}, {"entity": "publication", "iuid": "9bc47c462b2e4d38ad40b313692930b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9bc47c462b2e4d38ad40b313692930b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9bc47c462b2e4d38ad40b313692930b3"}}, "title": "Citizens' Use of eHealth Services During COVID-19 in Relation to National Policy Goals.", "authors": [{"family": "Koch", "given": "Sabine", "initials": "S"}, {"family": "Vimarlund", "given": "Vivian", "initials": "V"}], "type": "journal article", "published": "2022-06-29", "journal": {"title": "Stud Health Technol Inform", "issn": "1879-8365", "volume": "295", "pages": "12-15", "issn-l": null}, "abstract": "The main goals of the Swedish eHealth strategy are to enable citizens to achieve good and equal health and welfare, and to support self-determination and increased participation in society. We analyzed the relationship between these goals and the use of eHealth services offered for citizens prior to and during the COVID-19 pandemic. Data was collected through a national citizen survey issued in 2019 and 2021 to a sample size of 15.000 representative individuals each. Results showed that the use of eHealth services was highest in the 30-49 years age group and among respondents with high education. There were no major differences between respondents with high, medium, or low income, and neither between respondents with different degrees of self-perceived health, nor between native Swedish and non-Swedish respondents. Changes in use of different eHealth services over time were most probably related to the pandemic and are not significant. All age groups showed a similar relative increase regarding their use of eHealth services, except when searching the Internet for diagnosis and treatment where persons above 75 years of age had the largest increase. Most significant were the increase in online visits and the decrease in maintaining health, training, or food diaries. Strategic goals related to equity seem to be partly met as eHealth services are used to the same degree by different socio-economic groups. However, the older population uses eHealth services less than other age groups and a deeper understanding of the relationship between specific services and their impact on strategic goals is needed.", "doi": "10.3233/SHTI220647", "pmid": "35773793", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "SHTI220647"}], "notes": [], "created": "2022-08-17T13:14:11.436Z", "modified": "2022-08-17T13:14:11.466Z"}, {"entity": "publication", "iuid": "3a05f12e943b40df96ed49f68db01114", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a05f12e943b40df96ed49f68db01114.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a05f12e943b40df96ed49f68db01114"}}, "title": "Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2021.", "authors": [{"family": "Ikonomou", "given": "Laertis", "initials": "L"}, {"family": "Magnusson", "given": "Mattias", "initials": "M"}, {"family": "Dries", "given": "Ruben", "initials": "R"}, {"family": "Herzog", "given": "Erica L", "initials": "EL"}, {"family": "Hynds", "given": "Robert", "initials": "R"}, {"family": "Borok", "given": "Zea", "initials": "Z"}, {"family": "Park", "given": "Jin-Ah", "initials": "JA"}, {"family": "Skolasinski", "given": "Steven", "initials": "S"}, {"family": "Burgess", "given": "Janette K", "initials": "JK"}, {"family": "Turner", "given": "Leigh", "initials": "L"}, {"family": "Mojarad", "given": "Sarah M", "initials": "SM"}, {"family": "Mahoney", "given": "John E", "initials": "JE"}, {"family": "Lynch", "given": "Thomas", "initials": "T"}, {"family": "Lehmann", "given": "Mareike", "initials": "M"}, {"family": "Thannickal", "given": "Victor J", "initials": "VJ"}, {"family": "Hook", "given": "Jaime L", "initials": "JL"}, {"family": "Vaughan", "given": "Andrew E", "initials": "AE"}, {"family": "Hoffman", "given": "Evan T", "initials": "ET"}, {"family": "Weiss", "given": "Daniel J", "initials": "DJ"}, {"family": "Ryan", "given": "Amy L", "initials": "AL"}], "type": "journal article", "published": "2022-06-28", "journal": {"title": "Am J Physiol Lung Cell Mol Physiol", "issn": "1522-1504", "issn-l": null}, "abstract": "The 9th biennial conference titled \"Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases\" was hosted virtually, due to the ongoing COVID-19 pandemic, in collaboration with the University of Vermont Larner College of Medicine, the National Heart, Lung, and Blood Institute, the Alpha-1 Foundation, the Cystic Fibrosis Foundation, and the International Society for Cell & Gene Therapy. The event was held from July 12th through 15th, 2021 with a pre-conference workshop held July 9th. As in previous years the objectives remained to review and discuss the status of active research areas involving stem cells, cellular therapeutics, and bioengineering as they relate to the human lung. Topics included: 1) technological advancements in the in situ analysis of lung tissues, 2) new insights into stem cell signalling and plasticity in lung remodelling and regeneration, 3) the impact of extracellular matrix in stem cell regulation and airway engineering in lung regeneration, 4) differentiating and delivering stem cell therapeutics to the lung, 5) regeneration in response to viral infection, and 6) ethical development of cell-based treatments for lung diseases. This selection of topics represents some of the most dynamic and current research areas in lung biology. The virtual workshop included active discussion on state-of-the-art methods relating to the core features of the 2021 conference, including in-situ protemics, lung-on-chip, iPSC-airway differentiation, and light sheet microscopy. The conference concluded with an open discussion to suggest funding priorities and recommendations for future research directions in basic and translational lung biology.", "doi": "10.1152/ajplung.00113.2022", "pmid": "35762622", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-19T05:35:18.537Z", "modified": "2022-08-19T05:35:18.575Z"}, {"entity": "publication", "iuid": "d24b783fef17424e98d1271acb367c5b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d24b783fef17424e98d1271acb367c5b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d24b783fef17424e98d1271acb367c5b"}}, "title": "Low Prevalence of Mild Alpha-1-Antitrypsin Deficiency in Hospitalized COVID-19-Patients.", "authors": [{"family": "Nygren", "given": "David", "initials": "D", "orcid": "0000-0003-2426-7204", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d84ae6e240ec4a3caaf519a43f9d7cf9.json"}}, {"family": "M\u00f6lstad", "given": "Ulrica", "initials": "U"}, {"family": "Thulesius", "given": "Hans", "initials": "H", "orcid": "0000-0002-3785-5630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f7d45ab8dd94b89873fb2e44a0a8770.json"}}, {"family": "Hillman", "given": "Magnus", "initials": "M"}, {"family": "Broman", "given": "Lars Mikael", "initials": "LM", "orcid": "0000-0003-4124-4581", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6792bc7f2ba4afe931144a4a8a6bca9.json"}}, {"family": "Tanash", "given": "Hanan", "initials": "H"}, {"family": "Landin-Olsson", "given": "Mona", "initials": "M"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}, {"family": "Thunander", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2022-06-28", "journal": {"title": "Int J Gen Med", "issn": "1178-7074", "volume": "15", "pages": "5843-5848", "issn-l": null}, "abstract": "Alpha-1-antitrypsin (AAT) has been shown to inhibit SARS-CoV-2 cell entry and suggested as a therapeutic agent for COVID-19. Furthermore, epidemiological association of high prevalence of Alpha-1-antitrypsin deficiency (AATD) and regional severity of COVID-19-impact has been hypothesized. In our study setting, the estimated prevalence rates of mild (PI*MZ, PI*SS or PI*MS) and moderate-to-severe AATD (PI*ZZ or PI*SZ) are high, 9% and 0.2%, respectively. Our primary aim was to examine the prevalence rate of AATD among hospitalized COVID-19-patients.\n\nIn this prospective observational study, enrollment occurred from December 2020 to January 2021 in two COVID-19-units at Sk\u00e5ne University Hospital, Lund, Sweden. Case definition was a patient hospitalized due to COVID-19. Patients were screened for AATD with PI-typing and if results were inconclusive, PCR for the S- and Z-genes were performed. Patients were categorized as severe or moderate COVID-19 and 30-day-mortality data were collected. The primary outcome was prevalence rate of AATD. The secondary outcome investigated association between presence of mild AATD and severe COVID-19.\n\nWe enrolled 61 patients with COVID-19. Two patients out of 61 (3%) had mild AATD (PI*MZ) and none had moderate-to-severe AATD. 30/61 (49%) had severe COVID-19. Both patients with mild AATD developed severe COVID-19. Yet, presence of AATD was not significantly associated with severe COVID-19 (p=0.24).\n\nMild AATD (PI*MS or PI*MZ) was rare in a small cohort of hospitalized patients with COVID-19 in a study setting with a high background prevalence of AATD.", "doi": "10.2147/IJGM.S370434", "pmid": "35789772", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "370434"}, {"db": "pmc", "key": "PMC9250346"}], "notes": [], "created": "2022-08-17T13:08:54.738Z", "modified": "2022-08-17T13:08:54.844Z"}, {"entity": "publication", "iuid": "59dd4a10ac14474cab50fcc41b94cc76", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/59dd4a10ac14474cab50fcc41b94cc76.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/59dd4a10ac14474cab50fcc41b94cc76"}}, "title": "Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records.", "authors": [{"family": "Thompson", "given": "Ellen J", "initials": "EJ", "orcid": "0000-0003-2118-821X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6754739394b24a5c8f5db22905b22c3c.json"}}, {"family": "Williams", "given": "Dylan M", "initials": "DM", "orcid": "0000-0002-3825-2487", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8be5ce9d68b4fcb870f1dce11ccdaef.json"}}, {"family": "Walker", "given": "Alex J", "initials": "AJ", "orcid": "0000-0003-4932-6135", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/392cc8f956754fabbf68946bf8a3581a.json"}}, {"family": "Mitchell", "given": "Ruth E", "initials": "RE", "orcid": "0000-0002-3506-160X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cbf4d3aa699e4af69037e7539fb4497a.json"}}, {"family": "Niedzwiedz", "given": "Claire L", "initials": "CL", "orcid": "0000-0001-6133-4168", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9cf7719d211648ab98b572b231354e15.json"}}, {"family": "Yang", "given": "Tiffany C", "initials": "TC"}, {"family": "Huggins", "given": "Charlotte F", "initials": "CF"}, {"family": "Kwong", "given": "Alex S F", "initials": "ASF", "orcid": "0000-0003-1953-2771", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65ccb94351224dbdbcaa53d6ef6502ba.json"}}, {"family": "Silverwood", "given": "Richard J", "initials": "RJ", "orcid": "0000-0002-2744-1194", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d46ad9468444d3dbfbe8f392b9fb502.json"}}, {"family": "Di Gessa", "given": "Giorgio", "initials": "G", "orcid": "0000-0001-6154-1845", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c2319c222cc40069a5f55ead6d361f6.json"}}, {"family": "Bowyer", "given": "Ruth C E", "initials": "RCE", "orcid": "0000-0002-6941-8160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eebaf361c184499ca6729aa60cc0af3d.json"}}, {"family": "Northstone", "given": "Kate", "initials": "K"}, {"family": "Hou", "given": "Bo", "initials": "B"}, {"family": "Green", "given": "Michael J", "initials": "MJ", "orcid": "0000-0003-3193-2452", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84efba4af3264153b510906d0f4dcb35.json"}}, {"family": "Dodgeon", "given": "Brian", "initials": "B"}, {"family": "Doores", "given": "Katie J", "initials": "KJ", "orcid": "0000-0002-5507-1725", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d626ec20fb5d424e97a63b876f8cc5f5.json"}}, {"family": "Duncan", "given": "Emma L", "initials": "EL", "orcid": "0000-0002-8143-4403", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26eb842103da464986b66de7d7751548.json"}}, {"family": "Williams", "given": "Frances M K", "initials": "FMK", "orcid": "0000-0002-2998-2744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87a6db988c2e421f81fce7773436aefa.json"}}, {"family": "OpenSAFELY Collaborative", "given": "", "initials": ""}, {"family": "Steptoe", "given": "Andrew", "initials": "A", "orcid": "0000-0001-7808-4943", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/532fa7059d1941df934fb7c759a76057.json"}}, {"family": "Porteous", "given": "David J", "initials": "DJ", "orcid": "0000-0003-1249-6106", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8575eb112a94584aa4fc08ebf3b49b7.json"}}, {"family": "McEachan", "given": "Rosemary R C", "initials": "RRC"}, {"family": "Tomlinson", "given": "Laurie", "initials": "L", "orcid": "0000-0001-8848-9493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03f2034f701e46f3919a944d2ac325d7.json"}}, {"family": "Goldacre", "given": "Ben", "initials": "B"}, {"family": "Patalay", "given": "Praveetha", "initials": "P"}, {"family": "Ploubidis", "given": "George B", "initials": "GB"}, {"family": "Katikireddi", "given": "Srinivasa Vittal", "initials": "SV", "orcid": "0000-0001-6593-9092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9bcdfb6c28e742878e7df8ee66fa6863.json"}}, {"family": "Tilling", "given": "Kate", "initials": "K", "orcid": "0000-0002-1010-8926", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b5bd223d89f4d5cbfbf5decf107d5b9.json"}}, {"family": "Rentsch", "given": "Christopher T", "initials": "CT", "orcid": "0000-0002-1408-7907", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32d3afaa4b844ddb9ecc43e313b877ab.json"}}, {"family": "Timpson", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0002-7141-9189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90b26df69dcd46bd9f6e4eebbf46a36f.json"}}, {"family": "Chaturvedi", "given": "Nishi", "initials": "N", "orcid": "0000-0002-6211-2775", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94889a94593342f688fc89e9419ef7d0.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}], "type": "journal article", "published": "2022-06-28", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "3528", "issn-l": "2041-1723"}, "abstract": "The frequency of, and risk factors for, long COVID are unclear among community-based individuals with a history of COVID-19. To elucidate the burden and possible causes of long COVID in the community, we coordinated analyses of survey data from 6907 individuals with self-reported COVID-19 from 10 UK longitudinal study (LS) samples and 1.1 million individuals with COVID-19 diagnostic codes in electronic healthcare records (EHR) collected by spring 2021. Proportions of presumed COVID-19 cases in LS reporting any symptoms for 12+ weeks ranged from 7.8% and 17% (with 1.2 to 4.8% reporting debilitating symptoms). Increasing age, female sex, white ethnicity, poor pre-pandemic general and mental health, overweight/obesity, and asthma were associated with prolonged symptoms in both LS and EHR data, but findings for other factors, such as cardio-metabolic parameters, were inconclusive.", "doi": "10.1038/s41467-022-30836-0", "pmid": "35764621", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-022-30836-0"}, {"db": "pmc", "key": "PMC9240035"}], "notes": [], "created": "2022-08-19T05:34:48.695Z", "modified": "2022-08-19T05:34:49.333Z"}, {"entity": "publication", "iuid": "1a8957a53d6c4e6fb319f4649104f201", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1a8957a53d6c4e6fb319f4649104f201.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1a8957a53d6c4e6fb319f4649104f201"}}, "title": "Knowledge, Attitude, and Perception of Cancer Patients towards COVID-19 in Pakistan: A Cross-Sectional Study.", "authors": [{"family": "Khattak", "given": "Saadullah", "initials": "S", "orcid": "0000-0001-6798-2991", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/619a53d915304bab9bde893f36292393.json"}}, {"family": "Faheem", "given": "Muhammad", "initials": "M"}, {"family": "Nawaz", "given": "Bilawal", "initials": "B"}, {"family": "Khan", "given": "Maqbool", "initials": "M", "orcid": "0000-0001-7656-0184", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6328703e91874423a0344d277cdf4159.json"}}, {"family": "Khan", "given": "Nazeer Hussain", "initials": "NH", "orcid": "0000-0003-4380-233X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/965d14c87f584cefa64f774f34d0f711.json"}}, {"family": "Ullah", "given": "Nadeem", "initials": "N", "orcid": "0000-0001-6089-8906", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69e0776f1bec447ab4b94b7277ceb178.json"}}, {"family": "Khan", "given": "Taj Ali", "initials": "TA"}, {"family": "Khan", "given": "Rahat Ullah", "initials": "RU", "orcid": "0000-0002-7109-6201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ba9d38e92be45a18c3a95c9fc82fc93.json"}}, {"family": "Haleem", "given": "Kashif Syed", "initials": "KS"}, {"family": "Ren", "given": "Zhi-Guang", "initials": "ZG"}, {"family": "Wu", "given": "Dong-Dong", "initials": "DD"}, {"family": "Ji", "given": "Xin-Ying", "initials": "XY"}], "type": "journal article", "published": "2022-06-28", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "13", "issn-l": null}, "abstract": "Cancer patients, being immunocompromised, are at higher risk of coronavirus disease (COVID-19). The current study determines cancer patients' knowledge, attitude, perception, and impact of the COVID-19 pandemic.\n\nA cross-sectional online survey was conducted in Pakistan from 1 April 2020 to 1 May 2020. The study respondents were cancer patients with ages equal to or greater than 18 years. Following a request for participation, the URL for the survey was distributed on numerous channels. Other social media platforms, including WeChat, WhatsApp, Facebook, Twitter, Instagram, Messenger, and LinkedIn, were used to increase cancer patient interaction. The questionnaire comprised five different sections such as: (1) sociodemographic information, (2) knowledge, (3) attitude, (4) perception, and (5) impact of COVID-19 on cancer patients. Descriptive medical statistics such as frequency, percentage, mean, and standard deviation were used to illustrate the demographic characteristics of the study participants. To compare mean knowledge scores with selected demographic variables, independent sample t-tests and one-way analysis of variance (ANOVA) were used, which are also practical methods in epidemiological, public health and medical research. The cut-off point for statistical significance was set at a p-value of 0.05.\n\nMore than 300 cancer patients were invited, of which 208 agreed to take part. The response rate was 69.33% (208/300). Gender, marital status, and employment status had a significant association with knowledge scores. Of the total recruited participants, 96% (n = 200) (p &lt; 0.01) knew about COVID-19, and 90% were aware of general symptoms of COVID-19 disease, such as route of transmission and preventive measurements. In total, 94.5% (n = 197) (p &lt; 0.01) were willing to accept isolation if they were infected with COVID-19, and 98% (n = 204) (p &lt; 0.01) had reduced their use of public transportation. More than 90% (n = 188) (p &lt; 0.01) of cancer patients were found to be practicing preventative measures such as using a face mask, keeping social distance, and avoiding handshaking and hugging. Around 94.4% (n = 196) (p &lt; 0.01) of cancer patients had been impacted by, stopped or had changed cancer treatment during this pandemic, resulting in COVID-related anxiety and depression.\n\nThe included cancer patients exhibited a good level of COVID-19 knowledge, awareness, positive attitude, and perception. Large-scale studies and efforts are needed to raise COVID-19 awareness among less educated and high-risk populations. The present survey indicates that mass-level effective health education initiatives are required for developing countries to improve and reduce the gap between KAP and COVID-19.", "doi": "10.3390/ijerph19137926", "pmid": "35805584", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19137926"}, {"db": "pmc", "key": "PMC9265320"}], "notes": [], "created": "2022-08-17T10:43:25.603Z", "modified": "2022-08-17T10:43:25.804Z"}, {"entity": "publication", "iuid": "7dff34c69089449393aa9f3d89b939a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7dff34c69089449393aa9f3d89b939a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7dff34c69089449393aa9f3d89b939a2"}}, "title": "Case Report: Post-Partum SARS-CoV-2 Infection After the First French Uterus Transplantation.", "authors": [{"family": "Ayoubi", "given": "Jean Marc", "initials": "JM"}, {"family": "Carbonnel", "given": "Marie", "initials": "M"}, {"family": "Kvarnstr\u00f6m", "given": "Niclas", "initials": "N"}, {"family": "Revaux", "given": "Aurelie", "initials": "A"}, {"family": "Poulain", "given": "Marine", "initials": "M"}, {"family": "Vanlieferinghen", "given": "Sarah", "initials": "S"}, {"family": "Coatantiec", "given": "Yves", "initials": "Y"}, {"family": "Le Marchand", "given": "Mathilde", "initials": "M"}, {"family": "Tourne", "given": "Morgan", "initials": "M"}, {"family": "Pirtea", "given": "Paul", "initials": "P"}, {"family": "Snanoudj", "given": "Renaud", "initials": "R"}, {"family": "Le Guen", "given": "Morgan", "initials": "M"}, {"family": "Dahm-K\u00e4hler", "given": "Pernilla", "initials": "P"}, {"family": "Racowsky", "given": "Catherine", "initials": "C"}, {"family": "Br\u00e4nnstr\u00f6m", "given": "Mats", "initials": "M"}], "type": "case reports", "published": "2022-06-28", "journal": {"title": "Front Surg", "issn": "2296-875X", "volume": "9", "pages": "854225", "issn-l": null}, "abstract": "Absolute uterus factor infertility, whether congenital or acquired, renders the woman unable to carry a child. Although uterus transplantation (UTx) is being increasingly performed as a non-vital procedure to address this unfortunate condition, the immunosuppression required presents risks that are further compounded by pregnancy and during the puerperium period. These vulnerabilities require avoidance of SARS-CoV-2 infection in pregnant UTx recipients especially during the third trimester, as accumulating evidence reveals increased risks of morbidity and mortality. Here we describe a successful UTx case with delivery of a healthy child, but in which both mother and neonate developed asymptomatic SARS-CoV-2 infection seven days after RNA vaccination, on day 35 post-partum. Although the patient was successfully treated with a combination therapy comprised of two monoclonal antibodies, this case highlights the challenges associated with performing UTx in the era of Covid-19. More broadly, the risks of performing non-vital organ transplantation during a pandemic should be discussed among team members and prospective patients, weighing the risks against the benefits in improving the quality of life, which were considerable for our patient who achieved motherhood with the birth of a healthy child.", "doi": "10.3389/fsurg.2022.854225", "pmid": "35836605", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9273879"}], "notes": [], "created": "2022-08-12T08:59:34.409Z", "modified": "2022-08-12T08:59:34.435Z"}, {"entity": "publication", "iuid": "93005bbd70ac43e2aad57a176dd155c8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/93005bbd70ac43e2aad57a176dd155c8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/93005bbd70ac43e2aad57a176dd155c8"}}, "title": "Adapting teaching and learning in times of COVID-19: a comparative assessment among higher education institutions in a global health network in 2020.", "authors": [{"family": "Puradiredja", "given": "Dewi Ismajani", "initials": "DI"}, {"family": "Kintu-Sempa", "given": "Linda", "initials": "L"}, {"family": "Eyber", "given": "Carola", "initials": "C"}, {"family": "Weigel", "given": "Ralf", "initials": "R"}, {"family": "Broucker", "given": "Bruno", "initials": "B"}, {"family": "Lindkvist", "given": "Marie", "initials": "M"}, {"family": "Casamitjana", "given": "Nuria", "initials": "N"}, {"family": "Reynolds", "given": "Rodney", "initials": "R"}, {"family": "Klinkel", "given": "Hans-Friedemann", "initials": "H"}, {"family": "Matteelli", "given": "Alberto", "initials": "A"}, {"family": "Froeschl", "given": "Guenter", "initials": "G"}], "type": "journal article", "published": "2022-06-28", "journal": {"title": "BMC Med Educ", "issn": "1472-6920", "issn-l": null, "volume": "22", "issue": "1", "pages": "507"}, "abstract": "This research examines the ways in which higher education institutions (HEIs) across the tropEd Network for Education in International Health (tropEd) began to adapt their teaching and learning approaches in response to the COVID-19 pandemic in 2020. Already during this early phase of the pandemic HEIs' responses demonstrate global health approaches emphasising cooperation and communication, rather than national health driven strategies that emphasise quarantine and control. Key lessons learnt for multiple dimensions of teaching and learning in global health are thus identified, and challenges and opportunities discussed.\r\n\r\nData collection includes a cross-sectional online survey among tropEd member institutions (n = 19) in mid-2020, and a complementary set of open-ended questions generating free-text responses (n = 9). Quantitative data were analysed using descriptive statistics, textual data were analysed using a Framework Analysis approach.\r\n\r\nWhile early on in the pandemic the focus was on a quick emergency switch to online teaching formats to ensure short-term continuity, and developing the administrative and didactic competence and confidence in digital teaching, there is already recognition among HEIs of the necessity for more fundamental quality and longer-term reforms in higher education in global health. Alongside practical concerns about the limitations of digital teaching, and declines in student numbers, there is a growing awareness of opportunities in terms of inclusivity, the necessity of cross-border cooperation, and a global health approach. The extent to which the lack of physical mobility impacts HEI programmes in global health is debated.\r\n\r\nThe COVID-19 pandemic has brought about preventive measures that have had a considerable impact on various dimensions of academic teaching in global health. Going forward, international HEIs' experiences and response strategies can help generate important lessons for academic institutions across different settings worldwide.", "doi": "10.1186/s12909-022-03568-4", "pmid": "35764985", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12909-022-03568-4"}, {"db": "pmc", "key": "PMC9238047"}], "notes": [], "created": "2022-08-19T05:33:24.334Z", "modified": "2022-11-09T08:38:50.944Z"}, {"entity": "publication", "iuid": "19d3b486739b4d6f8691c56b2afa7a74", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19d3b486739b4d6f8691c56b2afa7a74.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19d3b486739b4d6f8691c56b2afa7a74"}}, "title": "Sensitization symptoms are associated with psychological and cognitive variables in COVID-19 survivors exhibiting post-COVID pain.", "authors": [{"family": "Fern\u00e1ndez-de-Las-Pe\u00f1as", "given": "C\u00e9sar", "initials": "C"}, {"family": "Par\u00e1s-Bravo", "given": "Paula", "initials": "P"}, {"family": "Ferrer-Pargada", "given": "Diego", "initials": "D", "orcid": "0000-0001-9088-5946", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a035c7a4f73a4ffd95b2f99695fdc2b0.json"}}, {"family": "Cancela-Cilleruelo", "given": "Ignacio", "initials": "I"}, {"family": "Rodr\u00edguez-Jim\u00e9nez", "given": "Jorge", "initials": "J"}, {"family": "Nijs", "given": "Jo", "initials": "J"}, {"family": "Arendt-Nielsen", "given": "Lars", "initials": "L"}, {"family": "Herrero-Montes", "given": "Manuel", "initials": "M", "orcid": "0000-0002-5732-8344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3460d36201934582b42366a9e2e736c0.json"}}], "type": "journal article", "published": "2022-06-27", "journal": {"title": "Pain Pract", "issn": "1533-2500", "issn-l": null}, "abstract": "To investigate the association between demographic, clinical, psychological, cognitive, and health-related variables and the Central Sensitization Inventory (CSI) in previously hospitalized COVID-19 survivors exhibiting \"de novo\" post-COVID pain.\n\nSeventy-seven (n = 77) COVID-19 survivors with \"de novo\" post-COVID pain completed demographic (age, height, and weight), clinical (duration and intensity of the pain), psychological (depressive/anxiety levels and sleep quality), cognitive (catastrophizing and kinesiophobia levels), and health-related quality of life variables as well as the CSI. A multivariable correlation analysis was conducted to determine the association between variables, and a stepwise multiple linear regression model was performed to identify CSI predictors.\n\nPatients were assessed a mean of 6.0 (SD 0.8) months after hospital discharge. Twenty-six (33.7%) individuals showed indications of sensitization-associated symptoms (CSI score \u226540 points). The CSI score was positively associated with pain intensity (r: 0.371), anxiety (r: 0.784), depressive (r: 0.709), catastrophizing (r: 0.620), and kinesiophobia (r: 0.359) levels (all, p < 0.001). The stepwise regression analysis revealed that 60.2% of CSI was explained by anxiety levels and pain intensity.\n\nThis study found that psychological and cognitive variables were associated with the CSI score in previously hospitalized COVID-19 survivors with \"de novo\" post-COVID pain. Anxiety levels and the intensity of pain symptoms were independently associated with CSI score suggesting a significant overlap with psychological construct. The \"de novo\" post-COVID pain association with CSI may indicate changes in the pain processing important for managing the pain.", "doi": "10.1111/papr.13146", "pmid": "35757896", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9350126"}], "notes": [], "created": "2022-08-19T05:37:46.172Z", "modified": "2022-08-19T05:37:46.280Z"}, {"entity": "publication", "iuid": "93c3450a3c054009a215c5c1b16e807e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/93c3450a3c054009a215c5c1b16e807e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/93c3450a3c054009a215c5c1b16e807e"}}, "title": "Associations between fear of COVID-19, dental anxiety, and psychological distress among Iranian adolescents.", "authors": [{"family": "Tofangchiha", "given": "Maryam", "initials": "M"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Scheerman", "given": "Janneke F M", "initials": "JFM"}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Ahonen", "given": "Hanna", "initials": "H"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Tadakamadla", "given": "Santosh Kumar", "initials": "SK"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2022-06-27", "journal": {"title": "BDJ Open", "issn": "2056-807X", "volume": "8", "issue": "1", "pages": "19", "issn-l": null}, "abstract": "The present study evaluated the association of fear of COVID-19 with dental anxiety, oral health-related quality of life (OHRQoL), and psychological distress (depression, anxiety and stress), as well as exploring the mediating role of dental anxiety in the association of fear of COVID-19 with OHRQoL and psychological distress.\n\nA cross-sectional study was conducted among adolescents in high schools of Qazvin city (Iran) from March-June 2021, recruited through a two-stage cluster sampling method. All the adolescents completed a self-administered survey assessing (i) fear of COVID-19, (ii) depression, anxiety and stress, (iii) OHRQoL, and (iv) dental anxiety. Structural equation modelling was used to evaluate all the hypothesised associations, and the model fit was estimated.\n\nA total of 2429 adolescents participated in the study. The conceptual model fitted the data well. Fear of COVID-19 had a direct effect on dental anxiety (B = 0.316; bias-corrected bootstrapping 95% CI = 0.282, 0.349), depression (B = 0.302; bias-corrected bootstrapping 95% CI = 0.259, 0.347), anxiety (B = 0.289; bias-corrected bootstrapping 95% CI = 0.246, 0.334), stress (B = 0.282; bias-corrected bootstrapping 95% CI = 0.237, 0.328), and OHRQoL (B = -0.354; bias-corrected bootstrapping 95% CI = -0.530, -0.183). Also, dental anxiety mediated the association of fear of COVID-19 with depression, anxiety stress, and OHRQoL.\n\nHigh levels of fear of COVID-19 were associated with high levels of dental anxiety and poorer OHRQoL. Moreover, fear of COVID-19 was positively associated with anxiety, depression and stress. Increased levels of dental anxiety were also associated with increased anxiety, stress, depression, and poorer OHRQoL.", "doi": "10.1038/s41405-022-00112-w", "pmid": "35760784", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41405-022-00112-w"}, {"db": "pmc", "key": "PMC9237055"}], "notes": [], "created": "2022-08-19T05:36:56.517Z", "modified": "2022-08-19T05:36:56.590Z"}, {"entity": "publication", "iuid": "e9703db559424cb8bf03af9e914f4275", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e9703db559424cb8bf03af9e914f4275.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e9703db559424cb8bf03af9e914f4275"}}, "title": "A comparative analysis of experienced uncertainties in relation to risk communication during COVID19: a four-country study.", "authors": [{"family": "Cristea", "given": "Florin", "initials": "F"}, {"family": "Weishaar", "given": "Heide", "initials": "H"}, {"family": "Geurts", "given": "Brogan", "initials": "B"}, {"family": "Delamou", "given": "Alexandre", "initials": "A"}, {"family": "Tan", "given": "Melisa Mei Jin", "initials": "MMJ"}, {"family": "Legido-Quigley", "given": "Helena", "initials": "H"}, {"family": "Aminu", "given": "Kafayat", "initials": "K"}, {"family": "Mari-S\u00e1ez", "given": "Almudena", "initials": "A"}, {"family": "Rocha", "given": "Carlos", "initials": "C"}, {"family": "Camara", "given": "Bienvenu", "initials": "B"}, {"family": "Barry", "given": "Lansana", "initials": "L"}, {"family": "Thea", "given": "Paul", "initials": "P"}, {"family": "Boucsein", "given": "Johannes", "initials": "J"}, {"family": "Bahr", "given": "Thurid", "initials": "T"}, {"family": "Al-Awlaqi", "given": "Sameh", "initials": "S"}, {"family": "Pozo-Martin", "given": "Francisco", "initials": "F"}, {"family": "Boklage", "given": "Evgeniya", "initials": "E"}, {"family": "Jegede", "given": "Ayodele Samuel", "initials": "AS"}, {"family": "Bcheraoui", "given": "Charbel El", "initials": "CE"}], "type": "journal article", "published": "2022-06-27", "journal": {"title": "Global Health", "issn": "1744-8603", "volume": "18", "issue": "1", "pages": "66", "issn-l": "1744-8603"}, "abstract": "During outbreaks, uncertainties experienced by affected communities can influence their compliance to government guidance on public health. Communicators and authorities are, hence, encouraged to acknowledge and address such uncertainties. However, in the midst of public health crises, it can become difficult to define and identify uncertainties that are most relevant to address. We analyzed data on COVID-19-related uncertainties from four socio-economic contexts to explore how uncertainties can influence people's perception of, and response to Risk Communication and Community Engagement (RCCE) strategies.\n\nThis qualitative study, which adopts an interpretative approach, is based on data from a documentary review, key informant interviews (KII), and focus group discussions (FGD) with members of the general public and people with barriers to information from Germany, Guinea, Nigeria, and Singapore. Transcripts from the KII and FGD were coded and analyzed thematically. We interviewed a total of 155 KIs and conducted 73 FGD. Our analysis uncovered a divergence between uncertainties deemed relevant by stakeholders involved in policy making and uncertainties that people reportedly had to navigate in their everyday lives and which they considered relevant during the pandemic. We identified four types of uncertainties that seemed to have influenced people's assessment of the disease risk and their trust in the pandemic control strategies including RCCE efforts: epidemiological uncertainties (related to the nature and severity of the virus), information uncertainties (related to access to reliable information), social uncertainties (related to social behavior in times of heightened risk), and economic uncertainties (related to financial insecurities).\n\nWe suggest that in future outbreaks, communicators and policy makers could improve the way in which affected communities assess their risk, and increase the trust of these communities in response efforts by addressing non-epidemiological uncertainties in RCCE strategies.", "doi": "10.1186/s12992-022-00857-x", "pmid": "35761365", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12992-022-00857-x"}, {"db": "pmc", "key": "PMC9235152"}], "notes": [], "created": "2022-08-19T05:35:54.224Z", "modified": "2022-08-19T05:35:54.240Z"}, {"entity": "publication", "iuid": "5913952e0d3b4443bcace68980cf43ed", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5913952e0d3b4443bcace68980cf43ed.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5913952e0d3b4443bcace68980cf43ed"}}, "title": "Socio-Ecological Factors and Well-Being among Self-Employed in Europe during the COVID-19 Pandemic.", "authors": [{"family": "Hansson", "given": "Josefine", "initials": "J", "orcid": "0000-0001-6385-1556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04f28c63354f4e11b27b8abdab4c58b7.json"}}, {"family": "Nordenmark", "given": "Mikael", "initials": "M"}, {"family": "Tjulin", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Landstad", "given": "Bodil J", "initials": "BJ"}, {"family": "Vinberg", "given": "Stig", "initials": "S", "orcid": "0000-0002-5935-5688", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c63c4ca58d242d18741dba0b0af5afb.json"}}], "type": "journal article", "published": "2022-06-26", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "13", "issn-l": null}, "abstract": "The self-employed are at increased risk of negative well-being outcomes when facing adversity such as the COVID-19 pandemic. Studies that examine socio-ecological factors that may protect their well-being are warranted.\n\nData were drawn from a cross-sectional survey of European self-employed people (n = 1665). The WHO-5 Well-being Index was used to examine the impact on well-being of factors at four socio-ecological levels. Independent sample t-tests, Pearson correlations and linear regression were applied to analyse differences between groups of self-employed and interactions between variables using SPSS.\n\nWell-being and the socio-ecological factors of resilience, social support, useful work and finding the rules clear were positively correlated with well-being. For self-employed who reported that it was challenging to run their business during the pandemic, social support and finding rules clear were of significantly greater importance to their well-being.\n\nThe findings highlight that the socio-ecological factors of resilience, social support, doing useful work and finding the rules clear affect well-being. The results also indicate that it is vital to consider factors at multiple socio-ecological levels to improve the well-being of the self-employed during adversity.", "doi": "10.3390/ijerph19137840", "pmid": "35805499", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19137840"}, {"db": "pmc", "key": "PMC9266291"}], "notes": [], "created": "2022-08-17T10:43:44.466Z", "modified": "2022-08-17T10:43:53.138Z"}, {"entity": "publication", "iuid": "375d0e6589464233885e6d24fbf73de0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/375d0e6589464233885e6d24fbf73de0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/375d0e6589464233885e6d24fbf73de0"}}, "title": "Epigenetic rewiring of pathways related to odour perception in immune cells exposed to SARS-CoV-2 in vivo and in vitro.", "authors": [{"family": "Huoman", "given": "Johanna", "initials": "J", "orcid": "0000-0003-2509-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83ac07f7b8c64d0090490070a3893006.json"}}, {"family": "Sayyab", "given": "Shumaila", "initials": "S", "orcid": "0000-0002-6048-775X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80e824deb3c54d2089f6615099188de1.json"}}, {"family": "Apostolou", "given": "Eirini", "initials": "E"}, {"family": "Karlsson", "given": "Lovisa", "initials": "L", "orcid": "0000-0003-2704-1788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2776385bc7d6419cb4378f33422425a0.json"}}, {"family": "Porcile", "given": "Lucas", "initials": "L", "orcid": "0000-0002-9164-4113", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4fe6ded8a7f74d64b9f1082da69f19ff.json"}}, {"family": "Rizwan", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-1725-8337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8aa9753dd6ae4622915f731fd54edf54.json"}}, {"family": "Sharma", "given": "Sumit", "initials": "S", "orcid": "0000-0003-0299-1285", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b6ce9aac5824a6f8d034a62e95f642f.json"}}, {"family": "Das", "given": "Jyotirmoy", "initials": "J", "orcid": "0000-0002-5649-4658", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/883ec5a66e47458fa303f9df2572f669.json"}}, {"family": "Ros\u00e9n", "given": "Anders", "initials": "A", "orcid": "0000-0001-5082-6423", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49ec1de9d88d4124a265b477662f0d0a.json"}}, {"family": "Lerm", "given": "Maria", "initials": "M", "orcid": "0000-0002-5092-9892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a326e1fb7efa4c4f8f59e7572f6b83bc.json"}}], "type": "journal article", "published": "2022-06-26", "journal": {"title": "Epigenetics", "issn": "1559-2308", "pages": "1-17", "issn-l": null}, "abstract": "A majority of SARS-CoV-2 recoverees develop only mild-to-moderate symptoms, while some remain completely asymptomatic. Although viruses, including SARS-CoV-2, may evade host immune responses by epigenetic mechanisms including DNA methylation, little is known about whether these modifications are important in defence against and healthy recovery from COVID-19 in the host. To this end, epigenome-wide DNA methylation patterns from COVID-19 convalescents were compared to uninfected controls from before and after the pandemic. Peripheral blood mononuclear cell (PBMC) DNA was extracted from uninfected controls, COVID-19 convalescents, and symptom-free individuals with SARS-CoV-2-specific T cell-responses, as well as from PBMCs stimulated in vitro with SARS-CoV-2. Subsequently, the Illumina MethylationEPIC 850K array was performed, and statistical/bioinformatic analyses comprised differential DNA methylation, pathway over-representation, and module identification analyses. Differential DNA methylation patterns distinguished COVID-19 convalescents from uninfected controls, with similar results in an experimental SARS-CoV-2 infection model. A SARS-CoV-2-induced module was identified in vivo, comprising 66 genes of which six (TP53, INS, HSPA4, SP1, ESR1, and FAS) were present in corresponding in vitro analyses. Over-representation analyses revealed involvement in Wnt, muscarinic acetylcholine receptor signalling, and gonadotropin-releasing hormone receptor pathways. Furthermore, numerous differentially methylated and network genes from both settings interacted with the SARS-CoV-2 interactome. Altered DNA methylation patterns of COVID-19 convalescents suggest recovery from mild-to-moderate SARS-CoV-2 infection leaves longstanding epigenetic traces. Both in vitro and in vivo exposure caused epigenetic modulation of pathways thataffect odour perception. Future studies should determine whether this reflects host-induced protective antiviral defense or targeted viral hijacking to evade host defence.", "doi": "10.1080/15592294.2022.2089471", "pmid": "35758003", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-19T05:37:15.000Z", "modified": "2022-08-19T05:37:15.278Z"}, {"entity": "publication", "iuid": "edd352e915f645408a416238fae795a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/edd352e915f645408a416238fae795a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/edd352e915f645408a416238fae795a1"}}, "title": "Seroprevalence of SARS-CoV-2 in Sweden, April 26 to May 9, 2021.", "authors": [{"family": "Beser", "given": "Jessica", "initials": "J"}, {"family": "Galanis", "given": "Ilias", "initials": "I"}, {"family": "Enkirch", "given": "Theresa", "initials": "T"}, {"family": "K\u00fchlmann Berenzon", "given": "Sharon", "initials": "S"}, {"family": "van Straten", "given": "Edward", "initials": "E"}, {"family": "Duracz", "given": "Jan", "initials": "J"}, {"family": "Rapp", "given": "Marie", "initials": "M"}, {"family": "Zakikhany", "given": "Katherina", "initials": "K"}, {"family": "Mansj\u00f6", "given": "Mikael", "initials": "M"}, {"family": "Wigren Bystr\u00f6m", "given": "Julia", "initials": "J"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Groenheit", "given": "Ramona", "initials": "R"}, {"family": "Tegmark Wisell", "given": "Karin", "initials": "K"}, {"family": "Br\u00e5ve", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2022-06-25", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "10816", "issn-l": "2045-2322"}, "abstract": "A national point seroprevalence study of SARS-CoV-2 was conducted in Sweden in April-May 2021. In total, 2860 individuals 3 to 90 years old from a probability-based web panel were included. Results showed that an estimated 32.6% of the population in Sweden had detectable levels of antibodies, and among non-vaccinated 20.1% had detectable levels of antibodies. We tested for differences in seroprevalence between age groups and by sex and estimated seroprevalence among previously infected participants by time since reporting.", "doi": "10.1038/s41598-022-15183-w", "pmid": "35752708", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-15183-w"}, {"db": "pmc", "key": "PMC9233662"}], "notes": [], "created": "2022-08-19T05:40:11.690Z", "modified": "2022-08-19T05:40:11.696Z"}, {"entity": "publication", "iuid": "49204daeaf184d10a9cef9d6c9613fc1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49204daeaf184d10a9cef9d6c9613fc1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49204daeaf184d10a9cef9d6c9613fc1"}}, "title": "Quality of life among health care workers with and without prior COVID-19 infection in Bangladesh.", "authors": [{"family": "Rahman", "given": "Mahfil Ara", "initials": "MA"}, {"family": "Sagar", "given": "Soumik Kha", "initials": "SK"}, {"family": "Dalal", "given": "Koustuv", "initials": "K", "orcid": "0000-0001-7393-796X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab5e44a17b7545988cb46cdf5b1f3e4e.json"}}, {"family": "Barsha", "given": "Sabrina Yesmin", "initials": "SY"}, {"family": "Ara", "given": "Tasnim", "initials": "T"}, {"family": "Khan", "given": "Md Abdullah Saeed", "initials": "MAS"}, {"family": "Saha", "given": "Shuvajit", "initials": "S"}, {"family": "Sarmin", "given": "Tanjina", "initials": "T"}, {"family": "Hossian", "given": "Mosharop", "initials": "M"}, {"family": "Nabi", "given": "Mohammad Hayatun", "initials": "MH"}, {"family": "Rahman", "given": "Mohammad Lutfor", "initials": "ML"}, {"family": "Hawlader", "given": "Mohammad Delwer Hossain", "initials": "MDH"}], "type": "journal article", "published": "2022-06-25", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "volume": "22", "issue": "1", "pages": "823", "issn-l": null}, "abstract": "Health care workers have been facing difficulties in coping with the COVID-19 infection from the beginning. The study aimed to compare Quality of Life (QOL) among health care workers (HCWs) with and without prior COVID-19 disease.\n\nThis study was conducted from July 2020 to January 2021 among 444 HCWs. We randomly interviewed 3244 participants for our earlier nationwide survey from a list of COVID-19 positive cases after their recovery, and we found 222 HCWs among the respondents. We randomly chose 222 HCWs unaffected by COVID as a comparison group from our selected hospitals. We measured QOL using World Health Organization's WHOQOL-BREF tool. Physical, psychological, environmental, and social ties were the four areas assessed on a 5-point Likert scale where a higher score suggests better QOL. Due to pandemic restrictions, we used telephonic interviews for data collection.\n\nA higher QOL score was observed in HCWs with prior COVID-19 infection in all four domains than HCWs without previous COVID-19 conditions. Comorbidity was negatively associated with QOL scores of the physical (p = 0.001) and (p < 0.001) and psychological (p = 0.05, and (p < 0.05) domains for non-COVID and COVID-affected groups, respectively. Current smoking was significantly associated with lower psychological (p = 0.019) and environmental (p = 0.007) QOL scores among HCWs with prior COVID-19 infection. Hospitalization history due to COVID infection was a contributing factor for lower physical QOL scores (p = 0.048). Environmental (p = 0.016) QOL scores were significantly associated with the monthly income in the prior COVID-19 infection group, and physical scores were significantly associated (p = 0.05) with a monthly income in the non-COVID group.\n\nGovernmental and non-governmental stakeholders should focus on potentially modifiable factors to improve health care workers' quality of life.", "doi": "10.1186/s12913-022-08174-0", "pmid": "35752784", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-022-08174-0"}, {"db": "pmc", "key": "PMC9233781"}], "notes": [], "created": "2022-08-19T05:39:51.105Z", "modified": "2022-08-19T05:39:51.148Z"}, {"entity": "publication", "iuid": "24907a395ed8437eb499edb4f4697bd8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24907a395ed8437eb499edb4f4697bd8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24907a395ed8437eb499edb4f4697bd8"}}, "title": "Have Health Inequalities Increased during the COVID-19 Pandemic? Evidence from Recent Years for Older European Union Citizens.", "authors": [{"family": "Gonz\u00e1lez Rodr\u00edguez", "given": "Irene", "initials": "I"}, {"family": "Pascual S\u00e1ez", "given": "Marta", "initials": "M"}, {"family": "Cantarero Prieto", "given": "David", "initials": "D"}], "type": "journal article", "published": "2022-06-25", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "13", "issn-l": null}, "abstract": "Reducing inequality is one of the current challenges that most societies are facing. Our aim was to analyze the evolution of inequalities in self-assessed health among older Europeans in a time period spanning the 2008 economic crisis and the COVID-19 health crisis. We used data from Waves 2, 4 and 8 of the Survey of Health, Ageing and Retirement in Europe. We used inequality indices that accept ordinal variables. Our empirical results suggest that average inequality declines over time. Gender significantly influences the results. Some of the countries with the highest level of inequality are Denmark and Sweden, and some with the lowest are Estonia and the Netherlands. Our results may be of interest for the development of public policies to reduce inequalities. Special attention should be paid to vulnerable groups, such as the elderly.", "doi": "10.3390/ijerph19137812", "pmid": "35805469", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19137812"}, {"db": "pmc", "key": "PMC9265733"}], "notes": [], "created": "2022-08-17T10:44:08.425Z", "modified": "2022-08-17T10:44:08.442Z"}, {"entity": "publication", "iuid": "1ce2276235264619893a58a1534fe868", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ce2276235264619893a58a1534fe868.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ce2276235264619893a58a1534fe868"}}, "title": "Children with psoriasis and COVID-19: factors associated with an unfavourable COVID-19 course, and the impact of infection on disease progression (Chi-PsoCov registry).", "authors": [{"family": "Zitouni", "given": "J", "initials": "J"}, {"family": "Bursztejn", "given": "A-C", "initials": "AC"}, {"family": "Belloni Fortina", "given": "A", "initials": "A", "orcid": "0000-0001-5791-0775", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f10eaae7700c4eee85c4bbd8947f5d21.json"}}, {"family": "Beauchet", "given": "A", "initials": "A"}, {"family": "Di Lernia", "given": "V", "initials": "V"}, {"family": "Lesiak", "given": "A", "initials": "A"}, {"family": "Thomas", "given": "J", "initials": "J"}, {"family": "Topkarci", "given": "Z", "initials": "Z"}, {"family": "Murashkin", "given": "N", "initials": "N", "orcid": "0000-0003-2252-8570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/780f117056524c3686f523771c79c35e.json"}}, {"family": "Brzezinski", "given": "P", "initials": "P", "orcid": "0000-0001-6817-606X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c59b93962ec045b39373303e1bdbd518.json"}}, {"family": "Torres", "given": "T", "initials": "T", "orcid": "0000-0003-0404-0870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54a6d84c2e9045eab3f506c4860aaeb3.json"}}, {"family": "Chiriac", "given": "A", "initials": "A", "orcid": "0000-0002-0989-4931", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a50fa61a4dc4d728e42c620fc06e8d0.json"}}, {"family": "Luca", "given": "C", "initials": "C"}, {"family": "McPherson", "given": "T", "initials": "T"}, {"family": "Akinde", "given": "M", "initials": "M"}, {"family": "Maruani", "given": "A", "initials": "A"}, {"family": "Epishev", "given": "R", "initials": "R"}, {"family": "Vidaurri de la Cruz", "given": "H", "initials": "H"}, {"family": "Luna", "given": "P C", "initials": "PC"}, {"family": "Amy de la Bret\u00eaque", "given": "M", "initials": "M"}, {"family": "Lasek", "given": "A", "initials": "A", "orcid": "0000-0002-4105-4027", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68e435ca02b345d6902a366c4e8e1879.json"}}, {"family": "Bourrat", "given": "E", "initials": "E"}, {"family": "Bachelerie", "given": "M", "initials": "M"}, {"family": "Mallet", "given": "S", "initials": "S"}, {"family": "Steff", "given": "M", "initials": "M"}, {"family": "Bellissen", "given": "A", "initials": "A"}, {"family": "Neri", "given": "I", "initials": "I"}, {"family": "Zafiriou", "given": "E", "initials": "E", "orcid": "0000-0002-6594-7292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/99d5a40411774f848f72fd5df470583c.json"}}, {"family": "van den Reek", "given": "J M P A", "initials": "JMPA"}, {"family": "Sonkoly", "given": "E", "initials": "E", "orcid": "0000-0002-4909-5413", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc17777e8b4e43ef918ddf68d3dce068.json"}}, {"family": "Mahil", "given": "S K", "initials": "SK"}, {"family": "Smith", "given": "C H", "initials": "CH", "orcid": "0000-0001-9918-1144", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4d49fa2c6a44215b42d5ee1e2e81190.json"}}, {"family": "Flohr", "given": "C", "initials": "C", "orcid": "0000-0003-4884-6286", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13d37914df3244d5ae62b9ece4ce2602.json"}}, {"family": "Bachelez", "given": "H", "initials": "H"}, {"family": "Mah\u00e9", "given": "E", "initials": "E", "orcid": "0000-0001-5780-1827", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f2012056d0e14e66a2d7f97812a768a5.json"}}, {"family": "Groupe de Recherche sur le Psoriasis (GrPso) of the Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie, the Groupe de recherche de la Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie P\u00e9diatrique (GR SFDP), the PsoProtect study group, the British Society of Paediatric Dermatology (BPSD), and the Societ\u00e0 Italiana di Dermatologia Pediatrica (S.I.Der.P.)", "given": "", "initials": ""}], "type": "journal article", "published": "2022-06-24", "journal": {"title": "J Eur Acad Dermatol Venereol", "issn": "1468-3083", "issn-l": null}, "abstract": "The COVID-19 pandemic has raised questions regarding the management of chronic skin diseases, especially in patients on systemic treatments. Data concerning the use of biologics in adults with psoriasis are reassuring, but data specific to children are missing. Moreover, COVID-19 could impact the course of psoriasis in children.\n\nThe aim of this study was therefore to assess the impact of COVID-19 on the psoriasis of children, and the severity of the infection in relation to systemic treatments.\n\nWe set up an international registry of paediatric psoriasis patients. Children were included if they were under 18 years of age, had a history of psoriasis, or developed it within 1 month of COVID-19 and had COVID-19 with or without symptoms.\n\nOne hundred and twenty episodes of COVID-19 in 117 children (mean age: 12.4 years) were reported. The main clinical form of psoriasis was plaque type (69.4%). Most children were without systemic treatment (54.2%); 33 (28.3%) were on biologic therapies, and 24 (20%) on non-biologic systemic drugs. COVID-19 was confirmed in 106 children (88.3%) and 3 children had two COVID-19 infections each. COVID-19 was symptomatic for 75 children (62.5%) with a mean duration of 6.5 days, significantly longer for children on non-biologic systemic treatments (P = 0.02) and without systemic treatment (P = 0.006) when compared with children on biologics. The six children who required hospitalization were more frequently under non-biologic systemic treatment when compared with the other children (P = 0.01), and particularly under methotrexate (P = 0.03). After COVID-19, the psoriasis worsened in 17 cases (15.2%). Nine children (8%) developed a psoriasis in the month following COVID-19, mainly a guttate form (P = 0.01).\n\nBiologics appear to be safe with no increased risk of severe form of COVID-19 in children with psoriasis. COVID-19 was responsible for the development of psoriasis or the worsening of a known psoriasis for some children.", "doi": "10.1111/jdv.18361", "pmid": "35748102", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9349726"}], "notes": [], "created": "2022-08-19T05:40:29.879Z", "modified": "2022-08-19T05:40:49.724Z"}, {"entity": "publication", "iuid": "ebacd66fb4254d659f20819fbec4c072", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ebacd66fb4254d659f20819fbec4c072.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ebacd66fb4254d659f20819fbec4c072"}}, "title": "Susceptibility of Patients with Asthma to Poor Outcome of COVID-19.", "authors": [{"family": "Persson", "given": "Carl", "initials": "C"}], "type": "journal article", "published": "2022-06-23", "journal": {"title": "Am J Respir Crit Care Med", "issn": "1535-4970", "issn-l": "1073-449X"}, "abstract": null, "doi": "10.1164/rccm.202205-0978LE", "pmid": "35737585", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-19T05:50:50.241Z", "modified": "2022-08-19T05:50:50.255Z"}, {"entity": "publication", "iuid": "649df7de666440e992c1c66547d697d6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/649df7de666440e992c1c66547d697d6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/649df7de666440e992c1c66547d697d6"}}, "title": "Long-COVID in children and adolescents: a systematic review and meta-analyses.", "authors": [{"family": "Lopez-Leon", "given": "Sandra", "initials": "S", "orcid": "0000-0001-7504-3441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/311cfec51fe9447283ee5c3a4ca0a3cd.json"}}, {"family": "Wegman-Ostrosky", "given": "Talia", "initials": "T", "orcid": "0000-0002-3207-6697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ebacfc4db6e4a04aab46b7172d828f2.json"}}, {"family": "Ayuzo Del Valle", "given": "Norma Cipatli", "initials": "NC", "orcid": "0000-0002-8110-3532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/222db71f009442798ef9b2ac782bb312.json"}}, {"family": "Perelman", "given": "Carol", "initials": "C", "orcid": "0000-0002-0111-1154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb4874d2c45c4d698c57f5e3705d306d.json"}}, {"family": "Sepulveda", "given": "Rosalinda", "initials": "R", "orcid": "0000-0003-1146-9552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e217c9ab8c24eeca127ffb1dd89b843.json"}}, {"family": "Rebolledo", "given": "Paulina A", "initials": "PA", "orcid": "0000-0002-9808-063X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bbee43f79e147b39028119e0b573c72.json"}}, {"family": "Cuapio", "given": "Angelica", "initials": "A", "orcid": "0000-0002-9451-1914", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f4915fdfa7d460f9b705b56b0fc1c4a.json"}}, {"family": "Villapol", "given": "Sonia", "initials": "S", "orcid": "0000-0002-6174-4113", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04eb73dcc16546b0b153a41bcba039af.json"}}], "type": "journal article", "published": "2022-06-23", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "9950", "issn-l": "2045-2322"}, "abstract": "The objective of this systematic review and meta-analyses is to estimate the prevalence of long-COVID in children and adolescents and to present the full spectrum of symptoms present after acute COVID-19. We have used PubMed and Embase to identify observational studies published before February 10th, 2022 that included a minimum of 30 patients with ages ranging from 0 to 18 years that met the National Institute for Healthcare Excellence (NICE) definition of long-COVID, which consists of both ongoing (4 to 12 weeks) and post-COVID-19 (\u2265 12 weeks) symptoms. Random-effects meta-analyses were performed using the MetaXL software to estimate the pooled prevalence with a 95% confidence interval (CI). Heterogeneity was assessed using I2 statistics. The Preferred Reporting Items for Systematic Reviewers and Meta-analysis (PRISMA) reporting guideline was followed (registration PROSPERO CRD42021275408). The literature search yielded 8373 publications, of which 21 studies met the inclusion criteria, and a total of 80,071 children and adolescents were included. The prevalence of long-COVID was 25.24%, and the most prevalent clinical manifestations were mood symptoms (16.50%), fatigue (9.66%), and sleep disorders (8.42%). Children infected by SARS-CoV-2 had a higher risk of persistent dyspnea, anosmia/ageusia, and/or fever compared to controls. Limitations of the studies analyzed include lack of standardized definitions, recall, selection, misclassification, nonresponse and/or loss of follow-up, and a high level of heterogeneity.", "doi": "10.1038/s41598-022-13495-5", "pmid": "35739136", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-13495-5"}, {"db": "pmc", "key": "PMC9226045"}], "notes": [], "created": "2022-08-19T05:50:23.537Z", "modified": "2022-08-19T05:50:30.738Z"}, {"entity": "publication", "iuid": "bf54121e5e9c41c7922320e941b41e55", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf54121e5e9c41c7922320e941b41e55.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf54121e5e9c41c7922320e941b41e55"}}, "title": "English dictionaries, gold and silver standard corpora for biomedical natural language processing related to SARS-CoV-2 and COVID-19", "authors": [{"family": "Kazemi Rashed", "given": "S", "initials": "S"}, {"family": "Ahmed", "given": "R", "initials": "R"}, {"family": "Frid", "given": "J", "initials": "J"}, {"family": "Aits", "given": "S", "initials": "S"}], "type": null, "published": "2022-06-23", "journal": {"title": "Arxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "https://doi.org/10.48550/arXiv.2003.09865", "pmid": null, "labels": {"Category: Health": null, "Type: Preprint": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "SRA", "key": "https://github.com/Aitslab/corona", "description": "https://github.com/Aitslab/corona"}, {"db": "URL", "key": "https://doi.org/10.5281/zenodo.6642275", "description": "https://doi.org/10.5281/zenodo.6642275"}], "notes": [], "created": "2022-06-23T06:26:18.948Z", "modified": "2023-02-22T08:06:48.608Z"}, {"entity": "publication", "iuid": "07b7e771e6d74fff82e04ed1d6be5533", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07b7e771e6d74fff82e04ed1d6be5533.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07b7e771e6d74fff82e04ed1d6be5533"}}, "title": "COVID-19 vaccine-induced adverse events predict immunogenicity among recipients of allogeneic haematopoietic stem cell transplantation.", "authors": [{"family": "Wiktorin", "given": "Hanna Grauers", "initials": "HG"}, {"family": "Einarsdottir", "given": "Sigrun", "initials": "S"}, {"family": "T\u00f6rnell", "given": "Andreas", "initials": "A"}, {"family": "Arabpour", "given": "Mohammad", "initials": "M"}, {"family": "Issdisai", "given": "Nuttida", "initials": "N"}, {"family": "Waldenstr\u00f6m", "given": "Jesper", "initials": "J"}, {"family": "Ringlander", "given": "Johan", "initials": "J"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K"}, {"family": "Martner", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-06-23", "journal": {"title": "Haematologica", "issn": "1592-8721", "issn-l": null}, "abstract": "Not available.", "doi": "10.3324/haematol.2022.280813", "pmid": "35734932", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-08-19T05:51:10.760Z", "modified": "2022-08-19T05:51:29.781Z"}, {"entity": "publication", "iuid": "4146548be296461e80f0b92a21d97c59", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4146548be296461e80f0b92a21d97c59.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4146548be296461e80f0b92a21d97c59"}}, "title": "Neurological Involvement in COVID-19 Among Non-Hospitalized Adolescents and Young Adults.", "authors": [{"family": "Havdal", "given": "Lise Beier", "initials": "LB"}, {"family": "Berven", "given": "Lise Lund", "initials": "LL"}, {"family": "Selvakumar", "given": "Joel", "initials": "J"}, {"family": "Stiansen-Sonerud", "given": "Tonje", "initials": "T"}, {"family": "Leegaard", "given": "Truls Michael", "initials": "TM"}, {"family": "Tjade", "given": "Trygve", "initials": "T"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Wyller", "given": "Vegard Bruun Bratholm", "initials": "VBB"}], "type": "journal article", "published": "2022-06-22", "journal": {"title": "Front Neurol", "issn": "1664-2295", "volume": "13", "pages": "915712", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) is prevalent among young people, and neurological involvement has been reported. We investigated neurological symptoms, cognitive test results, and biomarkers of brain injury, as well as associations between these variables in non-hospitalized adolescents and young adults with COVID-19.\n\nThis study reports baseline findings from an ongoing observational cohort study of COVID-19 cases and non-COVID controls aged 12-25 years (Clinical Trials ID: NCT04686734). Symptoms were charted using a standardized questionnaire. Cognitive performance was evaluated by applying tests of working memory, verbal learning, delayed recall, and recognition. The brain injury biomarkers, neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAp), were assayed in serum samples using ultrasensitive immunoassays.\n\nA total of 405 COVID-19 cases and 111 non-COVID cases were prospectively included. Serum Nfl and GFAp concentrations were significantly elevated in COVID-19 cases as compared with non-COVID controls (p = 0.050 and p = 0.014, respectively). The COVID-19 cases reported more fatigue (p < 0.001) and post-exertional malaise (PEM) (p = 0.001) compared to non-COVID-19 controls. Cognitive test performance and clinical neurological examination did not differ across the two groups. Within the COVID-19 group, there were no associations between symptoms, cognitive test results, and NfL or GFAp levels. However, fatigue and PEM were strongly associated with older age and female sex.\n\nNon-hospitalized adolescents and young adults with COVID-19 reported more fatigue and PEM and had slightly elevated levels of brain injury markers, but showed normal cognitive performance. No associations were found between symptoms, brain injury markers, and cognitive test results, but fatigue and PEM were strongly related to female sex and older age.", "doi": "10.3389/fneur.2022.915712", "pmid": "35812102", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9257204"}], "notes": [], "created": "2022-08-17T10:39:11.368Z", "modified": "2022-08-17T10:39:11.383Z"}, {"entity": "publication", "iuid": "3b9514af60f34b5a864db3b1ab5544eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b9514af60f34b5a864db3b1ab5544eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b9514af60f34b5a864db3b1ab5544eb"}}, "title": "Agile software development one year into the COVID-19 pandemic.", "authors": [{"family": "\u00c5gren", "given": "Pernilla", "initials": "P"}, {"family": "Knoph", "given": "Eli", "initials": "E"}, {"family": "Berntsson Svensson", "given": "Richard", "initials": "R"}], "type": "journal article", "published": "2022-06-22", "journal": {"title": "Empir Softw Eng", "issn": "1573-7616", "issn-l": null, "volume": "27", "issue": "6", "pages": "121"}, "abstract": "As a result of the COVID-19 pandemic, many agile practitioners had to transition into a remote work environment. Despite remote work not being a new concept for agile software practitioners, the forced or recommended nature of remote work is new. This study investigates how the involuntary shift to remote work and how social restrictions imposed by the COVID-19 pandemic have affected agile software development (ASD), and how agile practitioners have been affected in terms of ways of working. An explanatory sequential mixed methods study was performed. Data were collected one year into the COVID-19 pandemic through a questionnaire with 96 respondents and in-depth semi-structured interviews with seven practitioners from seven different companies. Data were analyzed through Bayesian analysis and thematic analysis. The results show, in general, that the aspects of ASD that have been the most affected is communication and social interactions, while technical work aspects have not experienced the same changes. Moreover, feeling forced to work remotely has a significant impact on different aspects of ASD, e.g., productivity and communication, and industry practitioners' employment of agile development and ways of working have primarily been affected by the lack of social interaction and the shift to digital communication. The results also suggest that there may be a group maturing debt when teams do go back into office, as digital communication and the lack of psychological safety stand in the way for practitioners' ability to have sensitive discussions and progress as a team in a remote setting.", "doi": "10.1007/s10664-022-10176-9", "pmid": "35757145", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10176"}, {"db": "pmc", "key": "PMC9214195"}], "notes": [], "created": "2022-08-19T05:38:34.428Z", "modified": "2022-11-09T08:40:12.194Z"}, {"entity": "publication", "iuid": "9a83041a95b949c2a1e8748cf44d5cd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9a83041a95b949c2a1e8748cf44d5cd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9a83041a95b949c2a1e8748cf44d5cd0"}}, "title": "S100A4 exerts robust mucosal adjuvant activity for co-administered antigens in mice.", "authors": [{"family": "Sen Chaudhuri", "given": "Arka", "initials": "A"}, {"family": "Yeh", "given": "Yu-Wen", "initials": "YW"}, {"family": "Zewdie", "given": "Olifan", "initials": "O"}, {"family": "Li", "given": "Nga Shan", "initials": "NS"}, {"family": "Sun", "given": "Jia-Bin", "initials": "JB"}, {"family": "Jin", "given": "Tao", "initials": "T"}, {"family": "Wei", "given": "Bin", "initials": "B"}, {"family": "Holmgren", "given": "Jan", "initials": "J"}, {"family": "Xiang", "given": "Zou", "initials": "Z", "orcid": "0000-0003-3925-0296", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61c1684aa00746dfae1bad8c84111033.json"}}], "type": "journal article", "published": "2022-06-21", "journal": {"title": "Mucosal Immunol", "issn": "1935-3456", "issn-l": null}, "abstract": "The lack of clinically applicable mucosal adjuvants is a major hurdle in designing effective mucosal vaccines. We hereby report that the calcium-binding protein S100A4, which regulates a wide range of biological functions, is a potent mucosal adjuvant in mice for co-administered antigens, including the SARS-CoV-2 spike protein, with comparable or even superior efficacy as cholera toxin but without causing any adverse reactions. Intranasal immunization with recombinant S100A4 elicited antigen-specific antibody and pulmonary cytotoxic T cell responses, and these responses were remarkably sustained for longer than 6 months. As a self-protein, S100A4 did not stimulate antibody responses against itself, a quality desired of adjuvants. S100A4 prolonged nasal residence of intranasally delivered antigens and promoted migration of antigen-presenting cells. S100A4-pulsed dendritic cells potently activated cognate T cells. Furthermore, S100A4 induced strong germinal center responses revealed by both microscopy and mass spectrometry, a novel label-free technique for measuring germinal center activity. Importantly, S100A4 did not induce olfactory bulb inflammation after nasal delivery, which is often a safety concern for nasal vaccination. In conclusion, S100A4 may be a promising adjuvant in formulating mucosal vaccines, including vaccines against pathogens that infect via the respiratory tract, such as SARS-CoV-2.", "doi": "10.1038/s41385-022-00535-6", "pmid": "35729204", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41385-022-00535-6"}, {"db": "pmc", "key": "PMC9212208"}], "notes": [], "created": "2022-08-17T13:06:09.232Z", "modified": "2022-08-17T13:06:09.309Z"}, {"entity": "publication", "iuid": "be0427dd3a9f4cb0b82fdfd48240a897", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be0427dd3a9f4cb0b82fdfd48240a897.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be0427dd3a9f4cb0b82fdfd48240a897"}}, "title": "Incidence of acute myocardial injury and its association with left and right ventricular systolic dysfunction in critically ill COVID-19 patients.", "authors": [{"family": "Jansson", "given": "Saga", "initials": "S"}, {"family": "Blixt", "given": "Patrik Johansson", "initials": "PJ"}, {"family": "Didriksson", "given": "Helen", "initials": "H"}, {"family": "Jonsson", "given": "Carina", "initials": "C"}, {"family": "Andersson", "given": "Henrik", "initials": "H"}, {"family": "Hedstr\u00f6m", "given": "Cassandra", "initials": "C"}, {"family": "Engvall", "given": "Jan", "initials": "J"}, {"family": "Aneq", "given": "Meriam \u00c5strom", "initials": "M\u00c5"}, {"family": "Chew", "given": "Michelle S", "initials": "MS", "orcid": "0000-0003-2888-4111", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c68391bb66e94be1ac0a14d69430666e.json"}}], "type": "journal article", "published": "2022-06-21", "journal": {"title": "Ann Intensive Care", "issn": "2110-5820", "volume": "12", "issue": "1", "pages": "56", "issn-l": null}, "abstract": "Previous studies have found an increase in cardiac troponins (cTns) and echocardiographic abnormalities in patients with COVID-19 and reported their association with poor clinical outcomes. Whether acute injury occurs during the course of critical care and if it is associated with cardiac function is unknown. The purpose of this study was to document the incidence of acute myocardial injury (AMInj) and echocardiographically defined left ventricular (LV) and right ventricular (RV) systolic dysfunction in consecutive patients admitted to an intensive care unit (ICU) for COVID-19. The relationship between AMInj and echocardiographic abnormalities during the first 14 days of ICU admission was studied. Finally, the association between echocardiographic findings, AMInj and clinical outcome was evaluated.\n\nSeventy-four consecutive patients (\u226518 years) admitted to the ICU at Link\u00f6ping University Hospital between 19 Mar 2020 and 31 Dec 2020 for COVID-19 were included. High-sensitivity troponin-T (hsTnT) was measured daily for up to 14 days. Transthoracic echocardiography was conducted within 72 h of ICU admission. Acute myocardial injury was defined as an increased hsTnT > 14ng/l and a > 20% absolute change with or without ischaemic symptoms. LV and RV systolic dysfunction was defined as at least 2 abnormal indicators of systolic function specified by consensus guidelines.\n\nIncreased hsTnT was observed in 59% of patients at ICU admission, and 82% developed AMInj with peak levels at 8 (3-13) days after ICU admission. AMInj was not statistically significantly associated with 30-day mortality but was associated with an increased duration of invasive mechanical ventilation (10 (3-13) vs. 5 days (0-9), p=0.001) as well as ICU length of stay (LOS) (19.5 (11-28) vs. 7 days (5-13), p=0.015). After adjustment for SAPS-3 and admission SOFA score, the effect of AMInj was significant only for the duration of mechanical ventilation (p=0.030). The incidence of LV and RV dysfunction was 28% and 22%, respectively. Only indices of LV and RV longitudinal contractility (mitral and tricuspid annular plane systolic excursion) were associated with AMInj. Echocardiographic parameters were not associated with clinical outcome.\n\nMyocardial injury is common in critically ill patients with COVID-19, with AMInj developing in more than 80% after ICU admission. In contrast, LV and RV dysfunction occurred in approximately one-quarter of patients. AMInj was associated with an increased need for mechanical ventilation and ICU LOS but neither AMInj nor ventricular dysfunction was significantly associated with mortality.", "doi": "10.1186/s13613-022-01030-8", "pmid": "35727386", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13613-022-01030-8"}, {"db": "pmc", "key": "PMC9210044"}], "notes": [], "created": "2022-08-17T13:05:26.592Z", "modified": "2022-08-17T13:05:26.639Z"}, {"entity": "publication", "iuid": "8c8b3c1318b14711a433112dcbf8867b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c8b3c1318b14711a433112dcbf8867b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c8b3c1318b14711a433112dcbf8867b"}}, "title": "Building social support: The impact of workgroup characteristics, the COVID-19 pandemic and informal interactions.", "authors": [{"family": "Pauksztat", "given": "Birgit", "initials": "B", "orcid": "0000-0002-2216-0836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c1db1125035420a81d17521e7a82755.json"}}, {"family": "Grech", "given": "Michelle R", "initials": "MR", "orcid": "0000-0002-3323-3607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b2aceb4dce745d780f36935b82dcb85.json"}}], "type": "journal article", "published": "2022-06-21", "journal": {"title": "Work", "issn": "1875-9270", "pages": "1175-1189", "volume": "72", "issue": "4", "issn-l": null}, "abstract": "Social support from colleagues is a key resource for employees and organizations, with beneficial effects on performance, employee well-being and resilience. Although the importance of social support is well-known, the factors that help to build and maintain social support are not equally well understood.\n\nThis study analyzes the impact of workgroup characteristics (i.e., workgroup composition regarding national diversity and tenure; workload) and the COVID-19 pandemic on employees' perceptions of instrumental and emotional support, and examines the mediating role of informal interactions.\n\nThe study is based on responses from 382 seafarers to a cross-sectional online survey. Hypotheses were tested using OLS regression and mediation analysis using PROCESS.\n\nWorkgroup composition regarding national diversity had indirect effects on social support through informal interactions around social foci (here: joint leisure activities). High workload and pressure from the COVID-19 pandemic reduced interactions around social foci, thus contributing to the erosion of perceived social support.\n\nThe findings provide insights on the development of social support, suggesting that informal interactions provide an important mechanism for the development of social support at work. From a theoretical perspective, this highlights the value of a relational perspective on the development of social support, a perspective that is based on the insight that social support is embedded in social relationships. From a practical point of view, this indicates that organizations can proactively foster the development of social support through practices that shape workgroup characteristics and social foci.", "doi": "10.3233/WOR-220020", "pmid": "35723163", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "WOR220020"}], "notes": [], "created": "2022-06-20T18:03:34.602Z", "modified": "2022-08-17T12:45:15.461Z"}, {"entity": "publication", "iuid": "10d1edf47a3741b49c5ce19be486db55", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/10d1edf47a3741b49c5ce19be486db55.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/10d1edf47a3741b49c5ce19be486db55"}}, "title": "Broadly Applicable, Virus-Free Dual Reporter Assay to Identify Compounds Interfering with Membrane Fusion: Performance for HSV-1 and SARS-CoV-2.", "authors": [{"family": "Classen", "given": "Nica", "initials": "N", "orcid": "0000-0002-2745-5748", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ac354339de048e4ba9a7903e4fe8c30.json"}}, {"family": "Ulrich", "given": "Diana", "initials": "D"}, {"family": "Hofemeier", "given": "Arne", "initials": "A"}, {"family": "Hennies", "given": "Marc Tim", "initials": "MT"}, {"family": "Hafezi", "given": "Wali", "initials": "W"}, {"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Romberg", "given": "Marie-Luise", "initials": "ML"}, {"family": "Lorentzen", "given": "Eva U", "initials": "EU", "orcid": "0000-0002-5570-1897", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9d0581149694958919de3f8fe6ef3cc.json"}}, {"family": "Hensel", "given": "Andreas", "initials": "A", "orcid": "0000-0003-0886-8384", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/458c0b3e8d9a47c083f86f80f542b582.json"}}, {"family": "K\u00fchn", "given": "Joachim E", "initials": "JE"}], "type": "journal article", "published": "2022-06-21", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "7", "issn-l": "1999-4915"}, "abstract": "Membrane fusion constitutes an essential step in the replication cycle of numerous viral pathogens, hence it represents an important druggable target. In the present study, we established a virus-free, stable reporter fusion inhibition assay (SRFIA) specifically designed to identify compounds interfering with virus-induced membrane fusion. The dual reporter assay is based on two stable Vero cell lines harboring the third-generation tetracycline (Tet3G) transactivator and a bicistronic reporter gene cassette under the control of the tetracycline responsive element (TRE3G), respectively. Cell-cell fusion by the transient transfection of viral fusogens in the presence of doxycycline results in the expression of the reporter enzyme secreted alkaline phosphatase (SEAP) and the fluorescent nuclear localization marker EYFPNuc. A constitutively expressed, secreted form of nanoluciferase (secNLuc) functioned as the internal control. The performance of the SRFIA was tested for the quantification of SARS-CoV-2- and HSV-1-induced cell-cell fusion, respectively, showing high sensitivity and specificity, as well as the reliable identification of known fusion inhibitors. Parallel quantification of secNLuc enabled the detection of cytotoxic compounds or insufficient transfection efficacy. In conclusion, the SRFIA reported here is well suited for high-throughput screening for new antiviral agents and essentially will be applicable to all viral fusogens causing cell-cell fusion in Vero cells.", "doi": "10.3390/v14071354", "pmid": "35891336", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "v14071354"}, {"db": "pmc", "key": "PMC9322530"}], "notes": [], "created": "2022-08-12T08:35:12.802Z", "modified": "2022-08-12T08:35:12.933Z"}, {"entity": "publication", "iuid": "0f95ab7453574fc49096b75980416597", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0f95ab7453574fc49096b75980416597.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0f95ab7453574fc49096b75980416597"}}, "title": "[Swedish gallstone surgery during the covid-19 pandemic].", "authors": [{"family": "Johan Drott", "given": "Carl", "initials": "C"}, {"family": "Sandblom", "given": "Gabriel", "initials": "G"}, {"family": "\u00d6sterberg", "given": "Johanna", "initials": "J"}, {"family": "Rogmark", "given": "Peder", "initials": "P"}, {"family": "Enochsson", "given": "Lars", "initials": "L"}], "type": "journal article", "published": "2022-06-20", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "volume": "119", "issn-l": "0023-7205"}, "abstract": "The covid-19 pandemic has necessitated reallocation of health care resources. This has raised concerns about the risks associated with postponing surgery for benign conditions that are given low priority. Data from the population-based Swedish National Register for Gallstone Surgery (GallRiks) show that the total number of procedures carried out during the initial months of each wave of the pandemic decreased. This was followed by a moderate increase in the number of procedures performed for acute cholecystitis, biliary pancreatitis, and obstructive jaundice. The consequences of the delayed surgery in the community at large and how this has affected health-related quality of life for patients having their procedure postponed remain to be evaluated, but so far it does not seem to have caused a major impact on public health.", "doi": null, "pmid": "35723571", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "21230"}], "notes": [], "created": "2022-08-17T12:44:12.527Z", "modified": "2022-08-17T12:44:12.540Z"}, {"entity": "publication", "iuid": "5b26867b6a75453abaea1cabf66361a3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5b26867b6a75453abaea1cabf66361a3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5b26867b6a75453abaea1cabf66361a3"}}, "title": "SARS-CoV-2 Specific Antibody Response and T Cell-Immunity in Immunocompromised Patients up to Six Months Post COVID: A Pilot Study.", "authors": [{"family": "Sj\u00f6wall", "given": "Johanna", "initials": "J", "orcid": "0000-0001-5622-866X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/352c62c6701e4bb89b3029d38803b9be.json"}}, {"family": "Hjorth", "given": "Maria", "initials": "M", "orcid": "0000-0002-4195-9387", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ccf79a5f280460aa963ce38b97bc5d7.json"}}, {"family": "Gustafsson", "given": "Annette", "initials": "A"}, {"family": "G\u00f6ransson", "given": "Robin", "initials": "R"}, {"family": "Larsson", "given": "Marie", "initials": "M", "orcid": "0000-0002-4524-0177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8d3f27eebb4456f965bc4da2c99176f.json"}}, {"family": "Waller", "given": "Hjalmar", "initials": "H"}, {"family": "Nordgren", "given": "Johan", "initials": "J", "orcid": "0000-0002-5349-2569", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad771e6e329b4442b045d31dddfdd8ec.json"}}, {"family": "Nilsdotter-Augustinsson", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0001-5719-5601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c315dcd94fd427ea248f6502de0229a.json"}}, {"family": "Nystr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0002-0145-4966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56bc7bc8ab444c81afd336394ae7607d.json"}}], "type": "journal article", "published": "2022-06-20", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "11", "issue": "12", "issn-l": "2077-0383"}, "abstract": "COVID-19 generates SARS-CoV-2-specific antibodies in immunocompetent individuals. However, in immunocompromised patients, the humoral immunity following infection may be impaired or absent. Recently, the assessment of cellular immunity to SARS-CoV-2, both following natural infection and vaccination, has contributed new knowledge regarding patients with low or no antibody responses. As part of a prospective cohort study which included hospitalized patients with COVID-19, we identified immunocompromised patients and compared them with age- and sex-matched immunocompetent patients regarding co-morbidities, biomarkers of COVID-19 and baseline viral load by real-time PCR in nasopharyngeal swabs. Spike and nucleocapsid antibody responses were analyzed at inclusion and after two weeks, six weeks and six months. Plasma immunoglobulin G (IgG) levels were quantified, lymphocyte phenotyping was performed, and SARS-CoV-2 specific CD4 and CD8 T cell responses after in vitro antigen stimulation were assessed at six months post infection. All patients showed IgG levels above or within reference limits. At six months, all patients had detectable SARS-CoV-2 anti-spike antibody levels. SARS-CoV-2 specific T cell responses were detected in 12 of 12 immunocompetent patients and in four of six immunocompromised patients. The magnitude of long-lived SARS-CoV-2 specific T cell responses were significantly correlated with the number of CD4 T cells and NK cells. Determining the durability of the humoral and cellular immune response against SARS-CoV-2 in immunocompromised individuals could be of importance by providing insights into the risk of re-infection and the need for vaccine boosters.", "doi": "10.3390/jcm11123535", "pmid": "35743605", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "jcm11123535"}, {"db": "pmc", "key": "PMC9225567"}], "notes": [], "created": "2022-08-19T05:44:04.368Z", "modified": "2022-08-19T05:44:22.039Z"}, {"entity": "publication", "iuid": "56677e17fc034e98afcf2e59f69e1242", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56677e17fc034e98afcf2e59f69e1242.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56677e17fc034e98afcf2e59f69e1242"}}, "title": "Integrating the CARD (Comfort Ask Relax Distract) system in a mass vaccination clinic to improve the experience of individuals during COVID-19 vaccination: a pre-post implementation study.", "authors": [{"family": "Tetui", "given": "Moses", "initials": "M"}, {"family": "Grindrod", "given": "Kelly", "initials": "K"}, {"family": "Waite", "given": "Nancy", "initials": "N"}, {"family": "VanderDoes", "given": "Jeremy", "initials": "J"}, {"family": "Taddio", "given": "Anna", "initials": "A", "orcid": "0000-0003-4432-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/383c983259be4b55b13c682f9d2a34bb.json"}}], "type": "journal article", "published": "2022-06-20", "journal": {"title": "Hum Vaccin Immunother", "issn": "2164-554X", "pages": "2089500", "issn-l": null}, "abstract": "Many people have negative experiences with vaccination due to stress-related reactions including fear and pain. We used a pre-post study design to evaluate the impact of implementing a modified version of the CARD (Comfort-Ask-Relax-Distract) system on stress-related reactions in individuals aged 12 y or older undergoing COVID-19 vaccinations in mass vaccination clinics. Vaccine recipients reported their level of pain, fear and dizziness during vaccination. Clinic staff reported their attitudes about CARD and use of CARD interventions. CARD improved client symptoms across genders and ages with an average reduction in needle pain, fear and dizziness of 75%, 40% and 44%, respectively. CARD was more effective in younger individuals. Clinic staff reported positive attitudes about CARD and uptake of selected CARD interventions. In summary, the modified CARD system reduced stress-related responses in a general population undergoing COVID-19 vaccinations in a mass vaccination clinic, was feasible and acceptable to staff. Future implementation efforts are recommended that include more diverse cultural contexts and incorporate education of individuals about CARD ahead of time.", "doi": "10.1080/21645515.2022.2089500", "pmid": "35723609", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-20T18:02:30.194Z", "modified": "2022-08-17T12:43:56.064Z"}, {"entity": "publication", "iuid": "c70af74a320e4b07ab68d297de9790b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c70af74a320e4b07ab68d297de9790b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c70af74a320e4b07ab68d297de9790b4"}}, "title": "Increase in admission rates and symptom severity of childhood and adolescent anorexia nervosa in Europe during the COVID-19 pandemic: data from specialized eating disorder units in different European countries.", "authors": [{"family": "Gilsbach", "given": "Susanne", "initials": "S"}, {"family": "Plana", "given": "Maria Teresa", "initials": "MT"}, {"family": "Castro-Fornieles", "given": "Josefina", "initials": "J"}, {"family": "Gatta", "given": "Michela", "initials": "M"}, {"family": "Karlsson", "given": "Gunilla Paulson", "initials": "GP"}, {"family": "Flamarique", "given": "Itziar", "initials": "I"}, {"family": "Raynaud", "given": "Jean-Philippe", "initials": "JP"}, {"family": "Riva", "given": "Anna", "initials": "A"}, {"family": "Solberg", "given": "Anne-Line", "initials": "AL"}, {"family": "van Elburg", "given": "Annemarie A", "initials": "AA"}, {"family": "Wentz", "given": "Elisabet", "initials": "E"}, {"family": "Nacinovich", "given": "Renata", "initials": "R"}, {"family": "Herpertz-Dahlmann", "given": "Beate", "initials": "B"}], "type": "journal article", "published": "2022-06-20", "journal": {"title": "Child Adolesc Psychiatry Ment Health", "issn": "1753-2000", "volume": "16", "issue": "1", "pages": "46", "issn-l": null}, "abstract": "The COVID-19 pandemic, associated with confinement and social isolation, seems to have impacted the course of many mental disorders in children and adolescents. An increase in hospital admission rates for juvenile anorexia nervosa (AN) has been documented in many regions of the world. However, data from Europe are scarce.\n\nWe asked clinicians in specialized eating disorder units in hospitals of maximum care in France, Germany, Italy, Spain, Sweden, and the Netherlands to report on (i) overall (inpatient and outpatient) and (ii) inpatient admission rates for adolescents with AN during 2019 and 2020. Additionally, a modified version of the COVID Isolation Eating Scale (CIES) was used to assess the child and adolescent psychiatrists' estimations of a possible increase in symptom severity in children and adolescents with AN during the COVID-19 pandemic and to (iii) inquire about the contributing factors perceived by the caring professionals.\n\nFour out of six representatives of European hospitals described a higher rate of overall admissions during the pandemic. Three hospitals out of six reported an increase in inpatient admissions, and two centres had constant high numbers of admissions of both outpatients and inpatients. The clinicians perceived a higher symptom severity in 2020 than in 2019, especially involving more frequent use of social media, longer duration of exercising, and more restrictive eating. They supposed an increase in social media consumption, a perceived \"loss of control\", and a lack of in-person assessments and weight controls as the main contributing factors for the deterioration in AN numbers and symptomatology.\n\nThe COVID-19 pandemic seems to have had a deep impact on symptom severity in AN, which is mirrored by a large increase in admission rates across Europe. An increase in exercise, social media consumption, a perceived \"loss of control\", and a lack of face-to-face health care seem to have contributed to this development. Further investigation is required to identify which factors may lead to the increase in incidence and deterioration of childhood and adolescent AN. Possible preventive means for the future could include educating paediatricians and health care workers about AN, regular weight assessment, and home-based treatments.", "doi": "10.1186/s13034-022-00482-x", "pmid": "35725621", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13034-022-00482-x"}, {"db": "pmc", "key": "PMC9208345"}], "notes": [], "created": "2022-08-17T13:04:58.818Z", "modified": "2022-08-17T13:04:58.831Z"}, {"entity": "publication", "iuid": "fa8fe4b9a71a4f3390db169213dcc235", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa8fe4b9a71a4f3390db169213dcc235.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa8fe4b9a71a4f3390db169213dcc235"}}, "title": "COVID-19 conspiracy ideation is associated with the delusion proneness trait and resistance to update of beliefs.", "authors": [{"family": "Acar", "given": "K", "initials": "K"}, {"family": "Horntvedt", "given": "O", "initials": "O"}, {"family": "Cabrera", "given": "A", "initials": "A"}, {"family": "Olsson", "given": "A", "initials": "A"}, {"family": "Ingvar", "given": "M", "initials": "M"}, {"family": "Lebedev", "given": "A V", "initials": "AV"}, {"family": "Petrovic", "given": "P", "initials": "P"}], "type": "journal article", "published": "2022-06-20", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "10352", "issn-l": "2045-2322"}, "abstract": "The rapid spread of conspiracy ideas associated with the recent COVID-19 pandemic represents a major threat to the ongoing and coming vaccination programs. Yet, the cognitive factors underlying the pandemic-related conspiracy beliefs are not well described. We hypothesized that such cognitive style is driven by delusion proneness, a trait phenotype associated with formation of delusion-like beliefs that exists on a continuum in the normal population. To probe this hypothesis, we developed a COVID-19 conspiracy questionnaire (CCQ) and assessed 577 subjects online. Their responses clustered into three factors that included Conspiracy, Distrust and Fear/Action as identified using principal component analysis. We then showed that CCQ (in particular the Conspiracy and Distrust factors) related both to general delusion proneness assessed with Peter's Delusion Inventory (PDI) as well as resistance to belief update using a Bias Against Disconfirmatory Evidence (BADE) task. Further, linear regression and pathway analyses suggested a specific contribution of BADE to CCQ not directly explained by PDI. Importantly, the main results remained significant when using a truncated version of the PDI where questions on paranoia were removed (in order to avoid circular evidence), and when adjusting for ADHD- and autistic traits (that are known to be substantially related to delusion proneness). Altogether, our results strongly suggest that pandemic-related conspiracy ideation is associated with delusion proneness trait phenotype.", "doi": "10.1038/s41598-022-14071-7", "pmid": "35725585", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-14071-7"}, {"db": "pmc", "key": "PMC9208343"}], "notes": [], "created": "2022-08-17T13:04:41.886Z", "modified": "2022-08-17T13:04:41.892Z"}, {"entity": "publication", "iuid": "ef5e6ee82251415ab0690481ddfaf624", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef5e6ee82251415ab0690481ddfaf624.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef5e6ee82251415ab0690481ddfaf624"}}, "title": "Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir.", "authors": [{"family": "Jemth", "given": "Ann-Sofie", "initials": "AS"}, {"family": "Scaletti", "given": "Emma Rose", "initials": "ER"}, {"family": "Homan", "given": "Evert", "initials": "E"}, {"family": "Stenmark", "given": "P\u00e5l", "initials": "P"}, {"family": "Helleday", "given": "Thomas", "initials": "T"}, {"family": "Michel", "given": "Maurice", "initials": "M"}], "type": "journal article", "published": "2022-06-19", "journal": {"title": "J Biol Chem", "issn": "1083-351X", "volume": "298", "issue": "8", "pages": "102169", "issn-l": "0021-9258"}, "abstract": "Remdesivir and molnupiravir have gained considerable interest because of their demonstrated activity against SARS-CoV-2. These antivirals are converted intracellularly to their active triphosphate forms remdesivir-TP and molnupiravir-TP. Cellular hydrolysis of these active metabolites would consequently decrease the efficiency of these drugs; however, whether endogenous enzymes that can catalyze this hydrolysis exist is unknown. Here, we tested remdesivir-TP as a substrate against a panel of human hydrolases and found that only Nudix hydrolase (NUDT) 18 catalyzed the hydrolysis of remdesivir-TP with notable activity. The kcat/Km value of NUDT18 for remdesivir-TP was determined to be 17,700 s-1M-1, suggesting that NUDT18-catalyzed hydrolysis of remdesivir-TP may occur in cells. Moreover, we demonstrate that the triphosphates of the antivirals ribavirin and molnupiravir are also hydrolyzed by NUDT18, albeit with lower efficiency than Remdesivir-TP. Low activity was also observed with the triphosphate forms of sofosbuvir and aciclovir. This is the first report showing that NUDT18 hydrolyzes triphosphates of nucleoside analogs of exogenous origin, suggesting that NUDT18 can act as a cellular sanitizer of modified nucleotides and may influence the antiviral efficacy of remdesivir, molnupiravir, and ribavirin. As NUDT18 is expressed in respiratory epithelial cells, it may limit the antiviral efficacy of remdesivir and molnupiravir against SARS-CoV-2 replication by decreasing the intracellular concentration of their active metabolites at their intended site of action.", "doi": "10.1016/j.jbc.2022.102169", "pmid": "35732208", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0021-9258(22)00611-1"}, {"db": "pmc", "key": "PMC9212496"}], "notes": [], "created": "2022-08-19T05:52:40.420Z", "modified": "2022-08-19T05:52:40.432Z"}, {"entity": "publication", "iuid": "f81a5edc998b42078e254d2da59c4dc0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f81a5edc998b42078e254d2da59c4dc0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f81a5edc998b42078e254d2da59c4dc0"}}, "title": "Sensitization-Associated Post-COVID-19 Symptoms at 6 Months Are Not Associated with Serological Biomarkers at Hospital Admission in COVID-19 Survivors: A Secondary Analysis of a Cohort Study.", "authors": [{"family": "Fern\u00e1ndez-de-Las-Pe\u00f1as", "given": "C\u00e9sar", "initials": "C", "orcid": "0000-0003-3772-9690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f64421a4c1b343f1a1bc17e02236f386.json"}}, {"family": "Herrero-Montes", "given": "Manuel", "initials": "M", "orcid": "0000-0002-5732-8344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3460d36201934582b42366a9e2e736c0.json"}}, {"family": "Ferrer-Pargada", "given": "Diego", "initials": "D"}, {"family": "Izquierdo-Cuervo", "given": "Sheila", "initials": "S"}, {"family": "Arendt-Nielsen", "given": "Lars", "initials": "L", "orcid": "0000-0003-0892-1579", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d147964e28949a49f9572be5317fc04.json"}}, {"family": "Nijs", "given": "Jo", "initials": "J", "orcid": "0000-0002-4976-6563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4c1747ed07f4ef6a09c589a4a9c9f2d.json"}}, {"family": "Par\u00e1s-Bravo", "given": "Paula", "initials": "P", "orcid": "0000-0001-7745-3006", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef0603c7d86b4098b44cfb4aeea8785f.json"}}], "type": "journal article", "published": "2022-06-18", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "11", "issue": "12", "issn-l": "2077-0383"}, "abstract": "Individuals who survived coronavirus disease, 2019 (COVID-19), often have symptoms of sensitization, but the extent to which these symptoms relate to serological biomarkers remains unclear. Therefore, this secondary analysis evaluated the association between serological biomarkers at hospital admission with sensitization-associated post-COVID-19 symptoms in a sample of previously hospitalized COVID-19 survivors. Sixty-seven individuals hospitalized due to SARS-CoV-2 infection in one urban hospital of Madrid (Spain) during the first wave of the pandemic were assessed a mean of 6.0 (SD 0.8) months after hospital discharge. The Central Sensitization Inventory (CSI) was used as rough tool to estimate the presence of sensitization-associated post-COVID-19 symptoms (\u226540/100 points). Levels of 16 serological biomarkers collected at hospital admission were obtained from medical records. Twenty-four (35.8%) patients reported sensitization-associated post-COVID-19 symptoms (CSI \u2265 40 points). Subjects reporting sensitization-associated symptoms had lower ferritin and hemoglobin levels than those not reporting sensitization-associated post-COVID-19 symptoms; however, these differences were small. We observed significant but small negative associations of the CSI score with ferritin (r: -0.251, p = 0.04) and hemoglobin (r: -0.292, p = 0.017) levels. No other significant difference was found. In conclusion, this secondary analysis did not find significant associations between the investigated serological biomarkers at hospital admission and sensitization-associated post-COVID-19 symptoms at 6 months after hospitalization in COVID-19 survivors.", "doi": "10.3390/jcm11123512", "pmid": "35743582", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "jcm11123512"}, {"db": "pmc", "key": "PMC9225549"}], "notes": [], "created": "2022-08-19T05:44:48.081Z", "modified": "2022-08-19T05:44:48.243Z"}, {"entity": "publication", "iuid": "348b1fa1816746bf9c15e7c4861df2ce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/348b1fa1816746bf9c15e7c4861df2ce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/348b1fa1816746bf9c15e7c4861df2ce"}}, "title": "Healthcare Professionals' Experience of Performing Digital Care Visits-A Scoping Review.", "authors": [{"family": "Lampickien\u0117", "given": "Ieva", "initials": "I"}, {"family": "Davoody", "given": "Nadia", "initials": "N", "orcid": "0000-0003-1813-8529", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/842dc06d06834029b4621c61a2623667.json"}}], "type": "journal article", "published": "2022-06-17", "journal": {"title": "Life (Basel)", "issn": "2075-1729", "volume": "12", "issue": "6", "issn-l": null}, "abstract": "The use of digital care visits has been increasing during the COVID-19 pandemic. Learning more about healthcare professionals' technology experiences provides valuable insight and a basis for improving digital visits. This study aimed to explore the existing literature on healthcare professionals' experience performing digital care visits. A scoping review was performed following Arksey & O'Malley's proposed framework using the Preferred Reporting Items for Systematic reviews and Meta-Analyses. The collected data were analyzed using thematic content analysis. Five main themes were identified in the literature: positive experiences/benefits, facilitators, negative experiences/challenges, barriers, and suggestions for improvement. Healthcare professionals mostly reported having an overall positive experience with digital visits and discovered benefits for themselves and the patients. However, opinions were mixed or negative regarding the complexity of decision making, workload and workflow, suitability of this type of care, and other challenges. The suggestions for improvement included training and education, improvements within the system and tools, along with support for professionals. Despite overall positive experiences and benefits for both professionals and patients, clinicians reported challenges such as physical barriers, technical issues, suitability concerns, and others. Digital care visits could not fully replace face-to-face visits.", "doi": "10.3390/life12060913", "pmid": "35743944", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "life12060913"}, {"db": "pmc", "key": "PMC9225275"}], "notes": [], "created": "2022-08-19T05:43:44.038Z", "modified": "2022-08-19T05:43:44.094Z"}, {"entity": "publication", "iuid": "983f426f18fc4baea38dc85d6d68cc0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/983f426f18fc4baea38dc85d6d68cc0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/983f426f18fc4baea38dc85d6d68cc0e"}}, "title": "COVID-19 vaccination-related adverse events among autoimmune disease patients: results from the COVAD study.", "authors": [{"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "R", "given": "Naveen", "initials": "N", "orcid": "0000-0003-2014-3925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c183c51a1f641b582c73ec15869f824.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Agarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Kardes", "given": "Sinan", "initials": "S", "orcid": "0000-0002-6311-8634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2900c3ca00da476a8914574384a3c9c2.json"}}, {"family": "Kim", "given": "Minchul", "initials": "M", "orcid": "0000-0001-9737-6255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd2952c6167b4733bfbce019a162b310.json"}}, {"family": "Day", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8528-4361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69468a24aa104a2faf0418f1a583515d.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "O'Callaghan", "given": "Albert Selva", "initials": "AS", "orcid": "0000-0003-2823-9761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef3e202c049b44a2a5e045bac90a393a.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Chatterjee", "given": "Tulika", "initials": "T", "orcid": "0000-0001-8844-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df600fda116449f5a048af7b245374fa.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Agarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-4508-1233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64ec523ccfe492c880c3a39137adc0c.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "COVAD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-06-17", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "issn-l": null}, "abstract": "COVID-19 vaccines have been proven to be safe in the healthy population. However, gaps remain in the evidence of their safety in patients with systemic autoimmune and inflammatory disorders (SAIDs). COVID-19 vaccination related adverse events (ADEs) in patients with SAIDs and healthy controls (HC) seven days post-vaccination were assessed in the COVAD study, a patient self-reported cross-sectional survey.\n\nThe survey was circulated in early 2021 by > 110 collaborators (94 countries) to collect SAID details, COVID-19 vaccination details, and 7-day vaccine ADEs, irrespective of respondent vaccination status. Analysis was performed based on data distribution and variable type.\n\n10900 respondents [42 (30-55) years, 74% females and 45% Caucasians] were analyzed. 5,867 patients (54%) with SAIDs were compared with 5033 HCs.79% had minor and only 3% had major vaccine ADEs requiring urgent medical attention (but not hospital admission) overall. Headache [SAIDs=26%, HCs=24%; OR = 1.1 (1.03-1.3); p = 0.014], abdominal pain [SAIDs=2.6%, HCs=1.4%; OR = 1.5 (1.1-2.3); p = 0.011], and dizziness [SAIDs=6%, HCs=4%; OR = 1.3 (1.07-1.6); p = 0.011], were slightly more frequent in SAIDs. Overall, major ADEs [SAIDs=4%, HCs=2%; OR = 1.9 (1.6-2.2); p < 0.001] and, specifically, throat closure [SAIDs=0.5%, HCs=0.3%; OR = 5.7 (2.9-11); p = 0.010] were more frequent in SAIDs though absolute risk was small (0-4%). Major ADEs and hospitalizations (less than 2%) were comparable across vaccine types in SAIDs.\n\nVaccination against COVID-19 is relatively safe in SAID patients. SAIDs were at a higher risk of major ADEs than HCs, though absolute risk was small. There are small differences in minor ADEs between vaccine types in SAID patients.", "doi": "10.1093/rheumatology/keac305", "pmid": "35713499", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6609762"}, {"db": "pmc", "key": "PMC9214139"}], "notes": [], "created": "2022-06-20T18:06:19.191Z", "modified": "2022-08-17T12:47:13.086Z"}, {"entity": "publication", "iuid": "556f775a8812436895594f18d49067f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/556f775a8812436895594f18d49067f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/556f775a8812436895594f18d49067f8"}}, "title": "Public anxiety through various stages of COVID-19 coping: Evidence from China.", "authors": [{"family": "Wu", "given": "Yangyang", "initials": "Y"}, {"family": "Zhang", "given": "Ting", "initials": "T"}, {"family": "Ye", "given": "Ziwen", "initials": "Z"}, {"family": "Chen", "given": "Kai", "initials": "K"}, {"family": "Kuijp", "given": "J van der", "initials": "JV"}, {"family": "Sun", "given": "Xue", "initials": "X"}, {"family": "Han", "given": "Guoyi", "initials": "G"}, {"family": "Zhao", "given": "Yi", "initials": "Y"}, {"family": "Liu", "given": "Yang", "initials": "Y", "orcid": "0000-0001-5477-2186", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43230a960dd84a27ba4777fcd2a0f189.json"}}, {"family": "Huang", "given": "Lei", "initials": "L", "orcid": "0000-0002-9279-878X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5bad866d23b4fd3902a7214f88f5484.json"}}], "type": "journal article", "published": "2022-06-16", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "6", "pages": "e0270229", "issn-l": "1932-6203"}, "abstract": "As countries underwent the initiation, peak, post-peak, and early vaccination stages of COVID-19, the changing risk perception, coping behaviors and corresponding psychological stress experienced by the public over time was rarely reported. We conducted a national scale panel study using social-psychological data collected from 5,983 questionnaires to investigate the interactions between anxiety level, risk perception and coping behavior during different stages of COVID-19 in China. We found that sustained perceiving worries of being infected, first due to domestic and then global pandemic, contributed to the persistent high proportion of respondents with anxiety disorders which even gradually increased over time (56.1% during initiation to 60.4% during early vaccination). Gender was the strongest predictor of anxiety at all stages, with females having less confidence in COVID-19 control and always suffering from much higher anxiety levels than males even during the post peak stage. Excessive protective behavior and frequency of access to COVID-related news also contributed to public anxiety. Additionally, public risk perception was significantly associated with their willingness to vaccinate. The findings verify the feasibility of taking stage-specific and gender-based risk communication strategies to alleviate the pandemic-related public anxiety and promote vaccination by influencing public risk perception and guiding coping behaviors.", "doi": "10.1371/journal.pone.0270229", "pmid": "35709292", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-22-05358"}, {"db": "pmc", "key": "PMC9202924"}], "notes": [], "created": "2022-06-20T18:07:18.211Z", "modified": "2022-08-17T12:47:43.967Z"}, {"entity": "publication", "iuid": "6c7c15fd98be42c6bff33bc2dd174b0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c7c15fd98be42c6bff33bc2dd174b0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c7c15fd98be42c6bff33bc2dd174b0e"}}, "title": "Novel genes and sex differences in COVID-19 severity.", "authors": [{"family": "Cruz", "given": "Raquel", "initials": "R", "orcid": "0000-0002-6964-8898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5697ffeaef2b40b584dc400b00544e76.json"}}, {"family": "Almeida", "given": "Silvia Diz-de", "initials": "SD"}, {"family": "Heredia", "given": "Miguel L\u00f3pez", "initials": "ML"}, {"family": "Quintela", "given": "In\u00e9s", "initials": "I"}, {"family": "Ceballos", "given": "Francisco C", "initials": "FC"}, {"family": "Pita", "given": "Guillermo", "initials": "G"}, {"family": "Lorenzo-Salazar", "given": "Jos\u00e9 M", "initials": "JM"}, {"family": "Gonz\u00e1lez-Montelongo", "given": "Rafaela", "initials": "R"}, {"family": "Gago-Dom\u00ednguez", "given": "Manuela", "initials": "M"}, {"family": "Porras", "given": "Marta Sevilla", "initials": "MS"}, {"family": "Casta\u00f1o", "given": "Jair Antonio Tenorio", "initials": "JAT"}, {"family": "Nevado", "given": "Julian", "initials": "J"}, {"family": "Aguado", "given": "Jose Mar\u00eda", "initials": "JM"}, {"family": "Aguilar", "given": "Carlos", "initials": "C"}, {"family": "Aguilera-Albesa", "given": "Sergio", "initials": "S"}, {"family": "Almadana", "given": "Virginia", "initials": "V"}, {"family": "Almoguera", "given": "Berta", "initials": "B"}, {"family": "Alvarez", "given": "Nuria", "initials": "N"}, {"family": "Andreu-Bernabeu", "given": "\u00c1lvaro", "initials": "\u00c1"}, {"family": "Arana-Arri", "given": "Eunate", "initials": "E"}, {"family": "Arango", "given": "Celso", "initials": "C"}, {"family": "Arranz", "given": "Mar\u00eda J", "initials": "MJ"}, {"family": "Artiga", "given": "Maria-Jesus", "initials": "MJ"}, {"family": "Baptista-Rosas", "given": "Ra\u00fal C", "initials": "RC"}, {"family": "Barreda-S\u00e1nchez", "given": "Mar\u00eda", "initials": "M"}, {"family": "Belhassen-Garcia", "given": "Moncef", "initials": "M"}, {"family": "Bezerra", "given": "Joao F", "initials": "JF"}, {"family": "Bezerra", "given": "Marcos A C", "initials": "MAC"}, {"family": "Boix-Palop", "given": "Luc\u00eda", "initials": "L"}, {"family": "Brion", "given": "Mar\u00eda", "initials": "M", "orcid": "0000-0001-7463-2148", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cd3234359d94481abd8238f3c3086cc.json"}}, {"family": "Brugada", "given": "Ram\u00f3n", "initials": "R"}, {"family": "Bustos", "given": "Matilde", "initials": "M"}, {"family": "Calder\u00f3n", "given": "Enrique J", "initials": "EJ", "orcid": "0000-0002-3166-5086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ec00f43e1fb43c6b754a31cbe723bbf.json"}}, {"family": "Carbonell", "given": "Cristina", "initials": "C"}, {"family": "Castano", "given": "Luis", "initials": "L"}, {"family": "Castelao", "given": "Jose E", "initials": "JE"}, {"family": "Conde-Vicente", "given": "Rosa", "initials": "R"}, {"family": "Cordero-Lorenzana", "given": "M Lourdes", "initials": "ML"}, {"family": "Cortes-Sanchez", "given": "Jose L", "initials": "JL"}, {"family": "Corton", "given": "Marta", "initials": "M"}, {"family": "Darnaude", "given": "M Teresa", "initials": "MT"}, {"family": "De Martino-Rodr\u00edguez", "given": "Alba", "initials": "A"}, {"family": "Campo-P\u00e9rez", "given": "Victor", "initials": "V"}, {"family": "Bustamante", "given": "Aranzazu Diaz", "initials": "AD"}, {"family": "Dom\u00ednguez-Garrido", "given": "Elena", "initials": "E"}, {"family": "Luchessi", "given": "Andre D", "initials": "AD"}, {"family": "Eir\u00f3s", "given": "Roc\u00edo", "initials": "R"}, {"family": "Sanabria", "given": "Gladys Mercedes Estigarribia", "initials": "GME"}, {"family": "Fari\u00f1as", "given": "Mar\u00eda Carmen", "initials": "MC"}, {"family": "Fern\u00e1ndez-Robelo", "given": "Ux\u00eda", "initials": "U"}, {"family": "Fern\u00e1ndez-Rodr\u00edguez", "given": "Amanda", "initials": "A"}, {"family": "Fern\u00e1ndez-Villa", "given": "Tania", "initials": "T"}, {"family": "Gil-Fournier", "given": "Bel\u00e9n", "initials": "B"}, {"family": "G\u00f3mez-Arrue", "given": "Javier", "initials": "J"}, {"family": "\u00c1lvarez", "given": "Beatriz Gonz\u00e1lez", "initials": "BG"}, {"family": "Quir\u00f3s", "given": "Fernan Gonzalez Bernaldo", "initials": "FGB"}, {"family": "Gonz\u00e1lez-Pe\u00f1as", "given": "Javier", "initials": "J"}, {"family": "Guti\u00e9rrez-Bautista", "given": "Juan F", "initials": "JF", "orcid": "0000-0003-1374-0756", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a426ebb240a54f0ab776e410f9244b70.json"}}, {"family": "Herrero", "given": "Mar\u00eda Jos\u00e9", "initials": "MJ"}, {"family": "Herrero-Gonzalez", "given": "Antonio", "initials": "A"}, {"family": "Jimenez-Sousa", "given": "Mar\u00eda A", "initials": "MA"}, {"family": "Lattig", "given": "Mar\u00eda Claudia", "initials": "MC"}, {"family": "Borja", "given": "Anabel Liger", "initials": "AL"}, {"family": "Lopez-Rodriguez", "given": "Rosario", "initials": "R"}, {"family": "Mancebo", "given": "Esther", "initials": "E"}, {"family": "Mart\u00edn-L\u00f3pez", "given": "Caridad", "initials": "C"}, {"family": "Mart\u00edn", "given": "Vicente", "initials": "V"}, {"family": "Martinez-Nieto", "given": "Oscar", "initials": "O"}, {"family": "Martinez-Lopez", "given": "Iciar", "initials": "I"}, {"family": "Martinez-Resendez", "given": "Michel F", "initials": "MF"}, {"family": "Martinez-Perez", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "Mazzeu", "given": "Juliana A", "initials": "JA"}, {"family": "Mac\u00edas", "given": "Eleuterio Merayo", "initials": "EM"}, {"family": "Minguez", "given": "Pablo", "initials": "P"}, {"family": "Cuerda", "given": "Victor Moreno", "initials": "VM"}, {"family": "Silbiger", "given": "Vivian N", "initials": "VN"}, {"family": "Oliveira", "given": "Silviene F", "initials": "SF"}, {"family": "Ortega-Paino", "given": "Eva", "initials": "E"}, {"family": "Parellada", "given": "Mara", "initials": "M"}, {"family": "Paz-Artal", "given": "Estela", "initials": "E"}, {"family": "Santos", "given": "Ney P C", "initials": "NPC"}, {"family": "P\u00e9rez-Matute", "given": "Patricia", "initials": "P"}, {"family": "Perez", "given": "Patricia", "initials": "P"}, {"family": "P\u00e9rez-Tom\u00e1s", "given": "M Elena", "initials": "ME"}, {"family": "Perucho", "given": "Teresa", "initials": "T"}, {"family": "Pinsach-Abuin", "given": "Mel Lina", "initials": "ML"}, {"family": "Pompa-Mera", "given": "Ericka N", "initials": "EN"}, {"family": "Porras-Hurtado", "given": "Gloria L", "initials": "GL"}, {"family": "Pujol", "given": "Aurora", "initials": "A"}, {"family": "Le\u00f3n", "given": "Soraya Ramiro", "initials": "SR"}, {"family": "Resino", "given": "Salvador", "initials": "S"}, {"family": "Fernandes", "given": "Marianne R", "initials": "MR"}, {"family": "Rodr\u00edguez-Ruiz", "given": "Emilio", "initials": "E"}, {"family": "Rodriguez-Artalejo", "given": "Fernando", "initials": "F"}, {"family": "Rodriguez-Garcia", "given": "Jos\u00e9 A", "initials": "JA"}, {"family": "Ruiz-Cabello", "given": "Francisco", "initials": "F"}, {"family": "Ruiz-Hornillos", "given": "Javier", "initials": "J"}, {"family": "Ryan", "given": "Pablo", "initials": "P"}, {"family": "Soria", "given": "Jos\u00e9 Manuel", "initials": "JM"}, {"family": "Souto", "given": "Juan Carlos", "initials": "JC"}, {"family": "Tamayo", "given": "Eduardo", "initials": "E"}, {"family": "Tamayo-Velasco", "given": "Alvaro", "initials": "A"}, {"family": "Taracido-Fernandez", "given": "Juan Carlos", "initials": "JC"}, {"family": "Teper", "given": "Alejandro", "initials": "A"}, {"family": "Torres-Tobar", "given": "Lilian", "initials": "L"}, {"family": "Urioste", "given": "Miguel", "initials": "M"}, {"family": "Valencia-Ramos", "given": "Juan", "initials": "J"}, {"family": "Y\u00e1\u00f1ez", "given": "Zuleima", "initials": "Z"}, {"family": "Zarate", "given": "Ruth", "initials": "R"}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T", "orcid": "0000-0001-9510-5646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd273e50091d44c3b3e8d1473ce89b0a.json"}}, {"family": "Pigazzini", "given": "Sara", "initials": "S"}, {"family": "Degenhardt", "given": "Frauke", "initials": "F", "orcid": "0000-0001-7516-3179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab8dc6a0eb504f41a89c140d68b87b6a.json"}}, {"family": "Butler-Laporte", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-5388-0396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/529dc69151d3463e8480b975d70fa759.json"}}, {"family": "Maya-Miles", "given": "Douglas", "initials": "D"}, {"family": "Bujanda", "given": "Luis", "initials": "L"}, {"family": "Bouysran", "given": "Youssef", "initials": "Y"}, {"family": "Palom", "given": "Adriana", "initials": "A"}, {"family": "Ellinghaus", "given": "David", "initials": "D"}, {"family": "Mart\u00ednez-Bueno", "given": "Manuel", "initials": "M"}, {"family": "Rolker", "given": "Selina", "initials": "S"}, {"family": "Amitrano", "given": "Sara", "initials": "S"}, {"family": "Roade", "given": "Luisa", "initials": "L"}, {"family": "Fava", "given": "Francesca", "initials": "F"}, {"family": "Spinner", "given": "Christoph D", "initials": "CD", "orcid": "0000-0002-3875-5367", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c506eb763b34155bbc6187f4ccb5f62.json"}}, {"family": "Prati", "given": "Daniele", "initials": "D"}, {"family": "Bernardo", "given": "David", "initials": "D"}, {"family": "Garcia", "given": "Federico", "initials": "F"}, {"family": "Darcis", "given": "Gilles", "initials": "G"}, {"family": "Fern\u00e1ndez-Cadenas", "given": "Israel", "initials": "I"}, {"family": "Holter", "given": "Jan Cato", "initials": "JC"}, {"family": "Banales", "given": "Jesus M", "initials": "JM"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Duga", "given": "Stefano", "initials": "S"}, {"family": "Asselta", "given": "Rosanna", "initials": "R"}, {"family": "Pereira", "given": "Alexandre C", "initials": "AC"}, {"family": "Romero-G\u00f3mez", "given": "Manuel", "initials": "M"}, {"family": "Nafr\u00eda-Jim\u00e9nez", "given": "Beatriz", "initials": "B"}, {"family": "Hov", "given": "Johannes R", "initials": "JR"}, {"family": "Migeotte", "given": "Isabelle", "initials": "I"}, {"family": "Renieri", "given": "Alessandra", "initials": "A", "orcid": "0000-0003-3818-0871", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b23966a465254ca6bbcd2c8ded62de72.json"}}, {"family": "Planas", "given": "Anna M", "initials": "AM"}, {"family": "Ludwig", "given": "Kerstin U", "initials": "KU", "orcid": "0000-0002-8541-2519", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02922a1f71c64a8e9dc6aa1c29a20270.json"}}, {"family": "Buti", "given": "Maria", "initials": "M"}, {"family": "Rahmouni", "given": "Souad", "initials": "S"}, {"family": "Alarc\u00f3n-Riquelme", "given": "Marta E", "initials": "ME"}, {"family": "Schulte", "given": "Eva C", "initials": "EC"}, {"family": "Franke", "given": "Andre", "initials": "A"}, {"family": "Karlsen", "given": "Tom H", "initials": "TH"}, {"family": "Valenti", "given": "Luca", "initials": "L"}, {"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "Richards", "given": "Brent", "initials": "B"}, {"family": "Ganna", "given": "Andrea", "initials": "A"}, {"family": "Boada", "given": "Merc\u00e8", "initials": "M"}, {"family": "Rojas", "given": "Itziar", "initials": "I"}, {"family": "Ruiz", "given": "Agust\u00edn", "initials": "A"}, {"family": "S\u00e1nchez", "given": "Pascual", "initials": "P"}, {"family": "Real", "given": "Luis Miguel", "initials": "LM"}, {"family": "SCOURGE Cohort Group", "given": "", "initials": ""}, {"family": "HOSTAGE Cohort Group", "given": "", "initials": ""}, {"family": "GRA@CE Cohort Group", "given": "", "initials": ""}, {"family": "Guillen-Navarro", "given": "Encarna", "initials": "E"}, {"family": "Ayuso", "given": "Carmen", "initials": "C"}, {"family": "Gonz\u00e1lez-Neira", "given": "Anna", "initials": "A"}, {"family": "Riancho", "given": "Jos\u00e9 A", "initials": "JA"}, {"family": "Rojas-Martinez", "given": "Augusto", "initials": "A", "orcid": "0000-0003-3765-6778", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e1011d5dcbe44319ea2cd8a03e63105.json"}}, {"family": "Flores", "given": "Carlos", "initials": "C"}, {"family": "Lapunzina", "given": "Pablo", "initials": "P"}, {"family": "Carracedo", "given": "\u00c1ngel", "initials": "\u00c1"}], "type": "journal article", "published": "2022-06-16", "journal": {"title": "Hum Mol Genet", "issn": "1460-2083", "issn-l": null}, "abstract": "Here we describe the results of a genome-wide study conducted in 11 939 COVID-19 positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (p < 5x10-8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (p = 1.3x10-22 and p = 8.1x10-12, respectively), and for variants in 9q21.32 near TLE1 only among females (p = 4.4x10-8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (p = 2.7x10-8) and ARHGAP33 (p = 1.3x10-8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, p = 4.1x10-8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or \u2265 60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.", "doi": "10.1093/hmg/ddac132", "pmid": "35708486", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6607933"}], "notes": [], "created": "2022-06-20T18:08:48.923Z", "modified": "2022-08-17T12:48:40.142Z"}, {"entity": "publication", "iuid": "2be82183ca284e4181fb956bc2d63ab6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2be82183ca284e4181fb956bc2d63ab6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2be82183ca284e4181fb956bc2d63ab6"}}, "title": "Lifestyle behaviors in Swedish university students before and during the first six months of the COVID-19 pandemic: a cohort study.", "authors": [{"family": "Larsson", "given": "Kristina", "initials": "K"}, {"family": "Onell", "given": "Clara", "initials": "C"}, {"family": "Edlund", "given": "Klara", "initials": "K"}, {"family": "K\u00e4llberg", "given": "Henrik", "initials": "H"}, {"family": "Holm", "given": "Lena W", "initials": "LW"}, {"family": "Sundberg", "given": "Tobias", "initials": "T"}, {"family": "Skillgate", "given": "Eva", "initials": "E"}], "type": "journal article", "published": "2022-06-16", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "1207", "issn-l": null}, "abstract": "Changes in Swedish university students' lifestyle behaviors during the COVID-19 pandemic are unknown. This study aimed to assess physical activity, sitting time, meal frequency and risk substance use (alcohol, tobacco, and illicit use of drugs) in Swedish university students before and during the first six months of the COVID-19 pandemic, for all and stratified by age and sex.\n\nData were obtained from the Sustainable University Life cohort study in which web-based surveys were sent to university students repeatedly for one year. Baseline assessment (before the pandemic) was between August 2019-March 2020, follow-up 1 (FU1) between March-June 2020, and follow-up 2 (FU2) between June-September 2020. Participants reported weekly minutes of physical activity, daily sitting hours, meal frequency by weekly intake of different meals, and motivation for eating irregularly, if so. Also, harmful use of alcohol, tobacco and illicit drugs was assessed. Population means and differences with 95% confidence intervals (95% CI) in lifestyle behaviors between time points were calculated with Generalized Estimating Equations.\n\n1877 students (73% women, mean age 26.5 years) answered the baseline survey. Weekly exercise decreased by -5.7 min (95% CI: -10.0, -1.5) and -7.7 min (95% CI: -12.6, -2.8) between baseline and FU1 and FU2, respectively. Weekly daily activities increased by 5.6 min (95% CI: 0.3, 11.7) and 14.2 min (95% CI: 7.9, 20.5) between baseline and FU1 and FU2. Daily sitting time decreased by -1.4 h (95% CI: -1.7, -1.2) between baseline and FU2. Breakfast intake increased by 0.2 days per week (95% CI: 0.1, 0.3) between baseline and FU2. Lunch intake decreased by -0.2 days per week (95% CI: -0.2, -0.1) between baseline and FU1 and by -0.2 days per week (95% CI: -0.3, -0.0) between baseline and FU2. Dinner intake decreased by -0.1 days per week (95% CI: -0.2, -0.0) between baseline and both FU1 and FU2. Only minor differences in risk substance use were observed. Similar changes were observed in analyses stratified by age and sex.\n\nLifestyle behaviors in Swedish university students slightly improved during the first six months of the COVID-19 pandemic compared to before.\n\nClinicalTrials.gov, NCT04465435 . 10/07/2020.", "doi": "10.1186/s12889-022-13553-7", "pmid": "35710368", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-022-13553-7"}, {"db": "pmc", "key": "PMC9202972"}, {"db": "ClinicalTrials.gov", "key": "NCT04465435"}], "notes": [], "created": "2022-06-20T18:06:39.900Z", "modified": "2022-08-17T12:47:29.378Z"}, {"entity": "publication", "iuid": "cab6d6e06fcb4e34bd7e7ffbb1a41682", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cab6d6e06fcb4e34bd7e7ffbb1a41682.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cab6d6e06fcb4e34bd7e7ffbb1a41682"}}, "title": "High Challenge Exercise and Learning Safe Landing Strategies among Community-Dwelling Older Adults: A Randomized Controlled Trial.", "authors": [{"family": "Arkkukangas", "given": "Marina", "initials": "M", "orcid": "0000-0001-7418-6088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70124d2b28fa4f8f868fb90bc786118d.json"}}, {"family": "Str\u00f6mqvist B\u00e5\u00e5the", "given": "Karin", "initials": "K"}, {"family": "Ekholm", "given": "Anna", "initials": "A"}, {"family": "Tonkonogi", "given": "Michail", "initials": "M"}], "type": "journal article", "published": "2022-06-16", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "12", "issn-l": null}, "abstract": "There is limited research on optimal exercise programs that effectively decrease falls and fall-related injuries in older populations. This randomized controlled trial (RCT) aimed to explore the effects of a 12-week Judo4Balance program on falling techniques, physical and psychological functions, health status, and physical activity levels among 200 community-dwelling older adults (79% women and 21% men) with a mean age of 72 years. The 200 participants were randomly allocated for the Judo4Balce program (n = 100) or control group (n = 100). The RCT intervention started in mid-January 2020 and was abruptly interrupted because of the COVID-19 pandemic. A restart of the RCT was initiated in September 2021, and the 12-week intervention was offered to two groups. This study reports the results from three points of assessment: baseline, 20-month follow-up, and 12-week postintervention. At 20 months follow-up, the control group had significantly decreased physical activity levels (summer p = 0.002 and winter p = 0.003); similar changes were not seen in the exercise group. In the exercise group, learning falling techniques in 6-9 weeks led to sustained fall competence at 20 months follow-up. Further, significant improvements in physical function (exercise group p = 0.009 and control group p &lt; 0.001) and learning falling techniques (p &lt; 0.001 for both groups) were noted in both groups after the 12-week intervention. This effective, supervised, group-based, high-challenge multicomponent exercise program needs to be further evaluated for possible impact on falls and fall-related injuries.", "doi": "10.3390/ijerph19127370", "pmid": "35742618", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19127370"}, {"db": "pmc", "key": "PMC9223480"}], "notes": [], "created": "2022-08-19T05:45:44.848Z", "modified": "2022-08-19T05:45:44.908Z"}, {"entity": "publication", "iuid": "33b737c22915436baa62eeefe8b586aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/33b737c22915436baa62eeefe8b586aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/33b737c22915436baa62eeefe8b586aa"}}, "title": "Private sector engagement in the COVID-19 response: experiences and lessons from the Democratic Republic of Congo, Nigeria, Senegal and Uganda.", "authors": [{"family": "Kabwama", "given": "Steven N", "initials": "SN"}, {"family": "Kiwanuka", "given": "Suzanne N", "initials": "SN"}, {"family": "Mapatano", "given": "Mala Ali", "initials": "MA"}, {"family": "Fawole", "given": "Olufunmilayo I", "initials": "OI"}, {"family": "Seck", "given": "Ibrahima", "initials": "I"}, {"family": "Namale", "given": "Alice", "initials": "A"}, {"family": "Ndejjo", "given": "Rawlance", "initials": "R"}, {"family": "Kizito", "given": "Susan", "initials": "S"}, {"family": "Monje", "given": "Fred", "initials": "F"}, {"family": "Bosonkie", "given": "Marc", "initials": "M"}, {"family": "Egbende", "given": "Landry", "initials": "L"}, {"family": "Bello", "given": "Segun", "initials": "S"}, {"family": "Bamgboye", "given": "Eniola A", "initials": "EA"}, {"family": "Dairo", "given": "Magbagbeola D", "initials": "MD"}, {"family": "Adebowale", "given": "Ayo S", "initials": "AS"}, {"family": "Salawu", "given": "Mobolaji M", "initials": "MM"}, {"family": "Afolabi", "given": "Rotimi F", "initials": "RF"}, {"family": "Diallo", "given": "Issakha", "initials": "I"}, {"family": "Leye", "given": "Mamadou M M", "initials": "MMM"}, {"family": "Ndiaye", "given": "Youssou", "initials": "Y"}, {"family": "Fall", "given": "Mane", "initials": "M"}, {"family": "Bassoum", "given": "Oumar", "initials": "O"}, {"family": "Alfv\u00e9n", "given": "Tobias", "initials": "T"}, {"family": "Sambisa", "given": "William", "initials": "W"}, {"family": "Wanyenze", "given": "Rhoda K", "initials": "RK"}], "type": "journal article", "published": "2022-06-15", "journal": {"title": "Global Health", "issn": "1744-8603", "issn-l": "1744-8603", "volume": "18", "issue": "1", "pages": "60"}, "abstract": "Private entities play a major role in health globally. However, their contribution has not been fully optimized to strengthen delivery of public health services. The COVID-19 pandemic has overwhelmed health systems and precipitated coalitions between public and private sectors to address critical gaps in the response. We conducted a study to document the public and private sector partnerships and engagements to inform current and future responses to public health emergencies.\r\n\r\nThis was a multi-country cross-sectional study conducted in the Democratic Republic of Congo, Nigeria, Senegal and Uganda between November 2020 and March 2021 to assess responses to the COVID-19 pandemic. We conducted a scoping literature review and key informant interviews (KIIs) with private and public health sector stakeholders. The literature reviewed included COVID-19 country guidelines and response plans, program reports and peer-reviewed and non-peer-reviewed publications. KIIs elicited information on country approaches and response strategies specifically the engagement of the private sector in any of the strategic response operations.\r\n\r\nAcross the 4 countries, private sector strengthened laboratory systems, COVID-19 case management, risk communication and health service continuity. In the DRC and Nigeria, private entities supported contact tracing and surveillance activities. Across the 4 countries, the private sector supported expansion of access to COVID-19 testing services through establishing partnerships with the public health sector albeit at unregulated fees. In Senegal and Uganda, governments established partnerships with private sector to manufacture COVID-19 rapid diagnostic tests. The private sector also contributed to treatment and management of COVID-19 cases. In addition, private entities provided personal protective equipment, conducted risk communication to promote adherence to safety procedures and health promotion for health service continuity. However, there were concerns related to reporting, quality and cost of services, calling for quality and price regulation in the provision of services.\r\n\r\nThe private sector contributed to the COVID-19 response through engagement in COVID-19 surveillance and testing, management of COVID-19 cases, and health promotion to maintain health access. There is a need to develop regulatory frameworks for sustainable public-private engagements including regulation of pricing, quality assurance and alignment with national plans and priorities during response to epidemics.", "doi": "10.1186/s12992-022-00853-1", "pmid": "35705961", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12992-022-00853-1"}, {"db": "pmc", "key": "PMC9199342"}], "notes": [], "created": "2022-06-20T18:10:41.041Z", "modified": "2022-08-17T12:58:09.908Z"}, {"entity": "publication", "iuid": "f9435aa3f85149de9a87c626478db9a5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f9435aa3f85149de9a87c626478db9a5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f9435aa3f85149de9a87c626478db9a5"}}, "title": "A prolonged innate systemic immune response in COVID-19.", "authors": [{"family": "Ekstedt", "given": "Sandra", "initials": "S"}, {"family": "Piersiala", "given": "Krzysztof", "initials": "K"}, {"family": "Petro", "given": "Marianne", "initials": "M"}, {"family": "Karlsson", "given": "Agneta", "initials": "A"}, {"family": "K\u00e5gedal", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Kumlien Geor\u00e9n", "given": "Susanna", "initials": "S"}, {"family": "Cardell", "given": "Lars Olaf", "initials": "LO"}], "type": "journal article", "published": "2022-06-15", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "9915", "issn-l": "2045-2322"}, "abstract": "Despite the introduction of vaccines, COVID-19 still affects millions of people worldwide. A better understanding of pathophysiology and the discovery of novel therapies are needed. One of the cells of interest in COVID-19 is the neutrophil. This cell type is being recruited to a site of inflammation as one of the first immune cells. In this project, we investigated a variety of neutrophils phenotypes during COVID-19 by measuring the expression of markers for migration, maturity, activation, gelatinase granules and secondary granules using flow cytometry. We show that neutrophils during COVID-19 exhibit altered phenotypes compared to healthy individuals. The activation level including NETs production and maturity of neutrophils seem to last longer during COVID-19 than expected for innate immunity. Neutrophils as one of the drivers of severe cases of COVID-19 are considered as potential treatment targets. However, for a successful implementation of treatment, there is a need for a better understanding of neutrophil functions and phenotypes in COVID-19. Our study answers some of those questions.", "doi": "10.1038/s41598-022-13986-5", "pmid": "35705573", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-13986-5"}, {"db": "pmc", "key": "PMC9200737"}], "notes": [], "created": "2022-06-20T18:11:26.239Z", "modified": "2022-08-17T12:58:20.345Z"}, {"entity": "publication", "iuid": "87cbba284ec34ff1b0a29296baf8f31a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87cbba284ec34ff1b0a29296baf8f31a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87cbba284ec34ff1b0a29296baf8f31a"}}, "title": "The Every Woman Every Child initiative: supporting countries in Latin America and the Caribbean to reduce social inequalities in health.", "authors": [{"family": "Sanhueza", "given": "Antonio", "initials": "A", "orcid": "0000-0002-1857-3662", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a16398c86edb49bd8bc6c4b70008e040.json"}}, {"family": "Carvajal", "given": "Liliana", "initials": "L", "orcid": "0000-0003-1971-7055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08223ee314804fd897aa13f5e08f7c1d.json"}}, {"family": "Cueva", "given": "Daniel A", "initials": "DA", "orcid": "0000-0002-1871-4680", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be76e4e1e7eb42179379897988af880d.json"}}, {"family": "Caffe", "given": "Sonja", "initials": "S"}, {"family": "Camacho", "given": "Alma Virginia", "initials": "AV"}, {"family": "Berroter\u00e1n", "given": "Mar\u00eda Alejandra", "initials": "MA"}, {"family": "Horowitz", "given": "Deborah", "initials": "D"}, {"family": "Gordillo-Tobar", "given": "Amparo", "initials": "A"}, {"family": "Mujica", "given": "Oscar J", "initials": "OJ", "orcid": "0000-0002-2893-4206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08cf1633e028495ca74ec9513246060b.json"}}, {"family": "Every Woman Every Child Latin America and the Caribbean", "given": "", "initials": ""}], "type": "letter", "published": "2022-06-14", "journal": {"title": "Int J Equity Health", "issn": "1475-9276", "volume": "21", "issue": "1", "pages": "83", "issn-l": null}, "abstract": "The Every Woman Every Child Latin America and the Caribbean (EWEC-LAC) initiative was established in 2017 as a regional inter-agency mechanism. EWEC-LAC coordinates the regional implementation of the Global Strategy for Women's, Children's and Adolescents' Health in Latin America and the Caribbean (LAC), including adaptation to region specific needs, to end preventable deaths, ensure health and well-being and expand enabling environments for the health and well-being of women, children and adolescents. To advance the equitable achievement of these objectives, EWEC-LAC's three working groups collectively support LAC countries in measuring and monitoring social inequalities in health, advocating for their reduction, and designing and implementing equity-oriented strategies, policies and interventions. This support for data-driven advocacy, capacity building, and policy and program solutions toward closing current gaps ensures that no one is left behind. Members of EWEC-LAC include PAHO, UNAIDS, UNFPA, UNICEF, UN WOMEN, the World Bank, the Inter-American Development Bank, USAID, LAC Regional Neonatal Alliance, and the LAC Regional Task Force for the Reduction of Maternal Mortality. To date, EWEC-LAC has developed and collected innovative tools and resources and begun to engage with countries to utilize them to reduce equity gaps. These resources include a framework for the measurement of social inequalities in health, data use and advocacy tools including a data dashboard to visualize trends in social inequalities in health in LAC countries, a methodology for setting targets for the reduction of inequalities, and a compendium of tools, instruments and methods to identify and address social inequalities in health. EWEC-LAC has also engaged regionally to emphasize the importance of recognizing these inequalities at social and political levels, and advocated for the reduction of these gaps. Attention to closing health equity gaps is ever more critical in the face of the COVID-19 pandemic which has exploited existing vulnerabilities. More equitable health systems will be better prepared to confront future health shocks.", "doi": "10.1186/s12939-022-01682-9", "pmid": "35701816", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12939-022-01682-9"}], "notes": [], "created": "2022-06-20T18:15:07.473Z", "modified": "2022-06-20T18:15:29.423Z"}, {"entity": "publication", "iuid": "c2262a7305c24e51974c262e891ff157", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2262a7305c24e51974c262e891ff157.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2262a7305c24e51974c262e891ff157"}}, "title": "Impaired Antibody Response Is Associated with Histone-Release, Organ Dysfunction and Mortality in Critically Ill COVID-19 Patients.", "authors": [{"family": "Lagedal", "given": "Rickard", "initials": "R"}, {"family": "Eriksson", "given": "Oskar", "initials": "O"}, {"family": "S\u00f6rman", "given": "Anna", "initials": "A", "orcid": "0000-0002-1037-1601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7aa6b3c26f634d14be04dc910700ef9f.json"}}, {"family": "Huckriede", "given": "Joram B", "initials": "JB"}, {"family": "Kristensen", "given": "Bjarne", "initials": "B"}, {"family": "Franz\u00e9n", "given": "Stephanie", "initials": "S", "orcid": "0000-0002-5003-2508", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e3799688c8d441fb9f3b62655c75ac26.json"}}, {"family": "Larsson", "given": "Anders", "initials": "A", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2be858ab604743b72383dfdcd14689.json"}}, {"family": "Bergqvist", "given": "Anders", "initials": "A", "orcid": "0000-0002-5789-8777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b0f16ae981064b70adf451e7fb517ab2.json"}}, {"family": "Alving", "given": "Kjell", "initials": "K", "orcid": "0000-0003-0784-0443", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa7365da4fc24c419cedd5d4e3266262.json"}}, {"family": "Forslund", "given": "Anders", "initials": "A"}, {"family": "Persson", "given": "Barbro", "initials": "B"}, {"family": "Ekdahl", "given": "Kristina N", "initials": "KN", "orcid": "0000-0001-7888-1571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a345be186f64a6ea106a3616baec50e.json"}}, {"family": "Garcia de Frutos", "given": "Pablo", "initials": "P", "orcid": "0000-0003-1547-1190", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8aa9ad9840f4838bb74c9eb3aac9658.json"}}, {"family": "Nilsson", "given": "Bo", "initials": "B"}, {"family": "Nicolaes", "given": "Gerry A F", "initials": "GAF"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}], "type": "journal article", "published": "2022-06-14", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "11", "issue": "12", "pages": null}, "abstract": "the pathophysiologic mechanisms explaining differences in clinical outcomes following COVID-19 are not completely described. This study aims to investigate antibody responses in critically ill patients with COVID-19 in relation to inflammation, organ failure and 30-day survival.\r\n\r\nAll patients with PCR-verified COVID-19 and gave consent, and who were admitted to a tertiary Intensive care unit (ICU) in Sweden during March-September 2020 were included. Demography, repeated blood samples and measures of organ function were collected. Analyses of anti-SARS-CoV-2 antibodies (IgM, IgA and IgG) in plasma were performed and correlated to patient outcome and biomarkers of inflammation and organ failure.\r\n\r\nA total of 115 patients (median age 62 years, 77% male) were included prospectively. All patients developed severe respiratory dysfunction, and 59% were treated with invasive ventilation. Thirty-day mortality was 22.6% for all included patients. Patients negative for any anti-SARS-CoV-2 antibody in plasma during ICU admission had higher 30-day mortality compared to patients positive for antibodies. Patients positive for IgM had more ICU-, ventilator-, renal replacement therapy- and vasoactive medication-free days. IgA antibody concentrations correlated negatively with both SAPS3 and maximal SOFA-score and IgM-levels correlated negatively with SAPS3. Patients with antibody levels below the detection limit had higher plasma levels of extracellular histones on day 1 and elevated levels of kidney and cardiac biomarkers, but showed no signs of increased inflammation, complement activation or cytokine release. After adjusting for age, positive IgM and IgG antibodies were still associated with increased 30-day survival, with odds ratio (OR) 7.1 (1.5-34.4) and 4.2 (1.1-15.7), respectively.\r\n\r\nIn patients with severe COVID-19 requiring intensive care, a poor antibody response is associated with organ failure, systemic histone release and increased 30-day mortality.", "doi": "10.3390/jcm11123419", "pmid": "35743491", "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "jcm11123419"}, {"db": "pmc", "key": "PMC9225468"}], "notes": [], "created": "2022-08-19T05:45:15.313Z", "modified": "2022-08-19T12:35:58.860Z"}, {"entity": "publication", "iuid": "f58f8a46b9894a2a99afee5da9ebc9c6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f58f8a46b9894a2a99afee5da9ebc9c6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f58f8a46b9894a2a99afee5da9ebc9c6"}}, "title": "Care home managers' views on the media coverage of COVID-19 outbreaks in care homes for older adults: A case study in Stockholm.", "authors": [{"family": "Morath", "given": "Lenke P", "initials": "LP"}, {"family": "Burstr\u00f6m", "given": "Bo", "initials": "B"}, {"family": "Liljas", "given": "Ann E M", "initials": "AEM", "orcid": "0000-0002-2358-6046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/669cff9e8a5b4042bd0019b7bd92d162.json"}}], "type": "journal article", "published": "2022-06-14", "journal": {"title": "Int J Older People Nurs", "issn": "1748-3743", "pages": "e12483", "issn-l": null}, "abstract": "The COVID-19 pandemic has particularly affected older adults and resulted in high rates of infections and deaths in care homes. We have conducted a case study in which three managers of care homes for older adults in central Stockholm have shared their thoughts on the media coverage of care homes for older adults during the COVID-19 pandemic. We analysed the data using conventional content analysis and identified three themes and five categories. The results show that the managers experienced the media coverage of care homes during the pandemic to be negative and incomplete, causing feelings of sadness and shame amongst themselves and their staff. The negative media coverage further generated added workload as they had to arrange for discussions to answer questions by staff and close relatives of the residents. Informants also thought that there is a lack of knowledge about the role of care homes and subsequently what to expect of them. Finally, informants reported that the pandemic might create an opportunity for system-level policy changes. In light of this, we discuss possible victim blaming of staff and how greater public awareness of the care home sector could facilitate for a debate on policy changes and the low social status of caring for older adults.", "doi": "10.1111/opn.12483", "pmid": "35699305", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9350000"}], "notes": [], "created": "2022-06-20T18:16:23.183Z", "modified": "2022-08-17T13:02:38.833Z"}, {"entity": "publication", "iuid": "51b7cb22b9794702a310bb4b49798ee4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/51b7cb22b9794702a310bb4b49798ee4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/51b7cb22b9794702a310bb4b49798ee4"}}, "title": "COVID-19 outcomes in haematopoietic cell transplant recipients: A systematic review and meta-analysis.", "authors": [{"family": "Lim", "given": "Yeong Jer", "initials": "YJ", "orcid": "0000-0002-9022-2904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8c08d684e83431b99d44a7a612b6325.json"}}, {"family": "Khan", "given": "Umair", "initials": "U"}, {"family": "Karpha", "given": "Indrani", "initials": "I"}, {"family": "Ross", "given": "Andrew", "initials": "A"}, {"family": "Saif", "given": "Muhammad", "initials": "M"}, {"family": "Remberger", "given": "Mats", "initials": "M"}, {"family": "Kalakonda", "given": "Nagesh", "initials": "N"}, {"family": "Pettitt", "given": "Andrew R", "initials": "AR"}, {"family": "Floisand", "given": "Yngvar", "initials": "Y"}], "type": "journal article", "published": "2022-06-14", "journal": {"title": "EJHaem", "issn": "2688-6146", "issn-l": null}, "abstract": "Up-to-date information on coronavirus disease 2019 (COVID-19) outcomes and risk factors in haematopoietic cell transplantation (HCT) recipients is required to inform on decisions about cancer treatment and COVID-19 mitigation strategies. We performed a meta-analysis to address this knowledge gap. All studies with at least five patients who reported COVID-19-related deaths in HCT recipients were included. The primary outcome was COVID-19-related death. Secondary outcomes were COVID-19-related mechanical ventilation (MV) and intensive care unit (ITU) admission. The cumulative COVID-19-related death rate among HCT recipients was 21% (95% confidence interval [CI] 18%-24%), while MV and ITU admission rates were 14% (95% CI 11%-17%) and 18% (95% CI 14%-22%), respectively. Subgroup analysis showed higher death rates in patients who developed COVID-19 within 12 months of HCT (risk ratio [RR] 1.82, 95% CI 1.09-3.03), within 6 months of receiving immunosuppressant drugs (RR 2.11, 95% CI 1.38-3.20) or in the context of active graft-versus-host disease (RR 2.38, 95% CI 1.10-5.16). Our findings support the idea that HCT should remain an integral part of cancer treatment during the COVID-19 pandemic but also highlight the need to prioritise preventative measures in those patients who are at increased risk of adverse COVID-19 outcomes.", "doi": "10.1002/jha2.465", "pmid": "35941880", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "JHA2465"}, {"db": "pmc", "key": "PMC9350043"}], "notes": [], "created": "2022-08-11T11:51:25.952Z", "modified": "2022-08-11T11:51:56.016Z"}, {"entity": "publication", "iuid": "c9f0e8da00d74515a863b2bed87412d1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9f0e8da00d74515a863b2bed87412d1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9f0e8da00d74515a863b2bed87412d1"}}, "title": "Athletes' Mesenchymal Stem Cells Could Be the Best Choice for Cell Therapy in Omicron-Infected Patients.", "authors": [{"family": "Saheli", "given": "Mona", "initials": "M"}, {"family": "Khoramipour", "given": "Kayvan", "initials": "K"}, {"family": "Vosough", "given": "Massoud", "initials": "M", "orcid": "0000-0001-5924-4366", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bf15c1fec524a79b8801694434587e3.json"}}, {"family": "Piryaei", "given": "Abbas", "initials": "A", "orcid": "0000-0002-3182-6214", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1807b026f88d4af8837f34b8d313843f.json"}}, {"family": "Rahmati", "given": "Masoud", "initials": "M", "orcid": "0000-0003-4792-027X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b5fa1a704f045eb97ff31ce02591801.json"}}, {"family": "Suzuki", "given": "Katsuhiko", "initials": "K", "orcid": "0000-0002-6572-5809", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00c6d85718554e2b9fd967bc69514508.json"}}], "type": "journal article", "published": "2022-06-14", "journal": {"title": "Cells", "issn": "2073-4409", "volume": "11", "issue": "12", "issn-l": null}, "abstract": "New severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, Omicron, contains 32 mutations that have caused a high incidence of breakthrough infections or re-infections. These mutations have reduced vaccine protection against Omicron and other new emerging variants. This highlights the need to find effective treatment, which is suggested to be stem cell-based therapy. Stem cells could support respiratory epithelial cells and they could restore alveolar bioenergetics. In addition, they can increase the secretion of immunomodulatory cytokines. However, after transplantation, cell survival and growth rate are low because of an inappropriate microenvironment, and stem cells face ischemia, inflammation, and oxidative stress in the transplantation niche which reduces the cells' survival and growth. Exercise-training can upregulate antioxidant, anti-inflammatory, and anti-apoptotic defense mechanisms and increase growth signaling, thereby improving transplanted cells' survival and growth. Hence, using athletes' stem cells may increase stem-cell therapy outcomes in Omicron-affected patients.", "doi": "10.3390/cells11121926", "pmid": "35741055", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "cells11121926"}, {"db": "pmc", "key": "PMC9221912"}], "notes": [], "created": "2022-08-19T05:48:12.702Z", "modified": "2022-08-19T05:48:12.833Z"}, {"entity": "publication", "iuid": "7cb12a386d7c47e4b404b7d606141ad1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7cb12a386d7c47e4b404b7d606141ad1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7cb12a386d7c47e4b404b7d606141ad1"}}, "title": "Olfactory distortions in the general population.", "authors": [{"family": "Olofsson", "given": "Jonas K", "initials": "JK"}, {"family": "Ekesten", "given": "Fredrik", "initials": "F"}, {"family": "Nordin", "given": "Steven", "initials": "S"}], "type": "journal article", "published": "2022-06-13", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "9776", "issn-l": "2045-2322"}, "abstract": "Parosmia, distorted smell sensations, is a common consequence of respiratory virus infections. The phenomenon is not well understood in terms of its impact and long-term outcomes. We examined self-reported experiences of parosmia in a population-based sample from the Betula study that was conducted in Ume\u00e5 in northern Sweden (baseline data collected in 1998-2000). We used a baseline sample of 2168 individuals aged 35-90 years and with no cognitive impairment at baseline. We investigated the prevalence of parosmia experiences and, using regression analyses, its relationship to other olfactory and cognitive variables and quality of life. Benefitting from the longitudinal study design, we also assessed the persistence of parosmia over 5 and 10 years prospectively. Parosmia experiences were prevalent in 4.8% of the population and it often co-occurred with phantosmia (\"olfactory hallucinations\"), but was not associated with lower self-rated overall quality of life or poor performance on olfactory or cognitive tests. For some individuals, parosmia was retained 5 years (17.0%) or even 10 years later (10.3%). Thus, parosmia experiences are commonly reported in the population, and can be persistent for some individuals, but might be mostly benign in nature. Our work complements research on clinical-level parosmia, which is typically more severe, and recent parosmia reports during the COVID-19 pandemic, where long-term outcomes are still unknown.", "doi": "10.1038/s41598-022-13201-5", "pmid": "35697904", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-13201-5"}], "notes": [], "created": "2022-06-20T18:18:24.318Z", "modified": "2022-06-20T18:18:24.332Z"}, {"entity": "publication", "iuid": "f461eb0c2e0f4a5cb43861847a056bfa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f461eb0c2e0f4a5cb43861847a056bfa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f461eb0c2e0f4a5cb43861847a056bfa"}}, "title": "Influence on study outcomes of an inpatient study by the behavior of the study staff (PINgPOng): study protocol for a randomized clinical trial.", "authors": [{"family": "Coenen", "given": "Martin", "initials": "M", "orcid": "0000-0003-0439-4409", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5bf4db2156e4f24b3ffcd88a024da9a.json"}}, {"family": "Bingel", "given": "Ulrike", "initials": "U"}, {"family": "Zunhammer", "given": "Matthias", "initials": "M"}, {"family": "Berdaguer", "given": "Maria Soledad", "initials": "MS"}, {"family": "Fuhrmann", "given": "Christine", "initials": "C"}, {"family": "Fimmers", "given": "Rolf", "initials": "R"}, {"family": "Rengelshausen", "given": "Jens", "initials": "J"}, {"family": "Hartmann", "given": "Gunther", "initials": "G"}, {"family": "Schedlowski", "given": "Manfred", "initials": "M"}, {"family": "Coch", "given": "Christoph", "initials": "C"}], "type": "clinical trial protocol", "published": "2022-06-13", "journal": {"title": "Trials", "issn": "1745-6215", "volume": "23", "issue": "1", "pages": "488", "issn-l": null}, "abstract": "The placebo effect as the symptom improvement following inert treatments is a fixed component of RCTs to differentiate between specific effects of the tested pharmacological substance from other unspecific effects. The PINgPOng study was set up to analyze the influence of a study team trained to either minimize the placebo response and optimize drug-placebo differences or to maximize the placebo response to increase drug efficacy by unspecific factors on the study results of a RCT in a classical early clinical trial setting.\n\nPINgPOng is a single-center, prospective, randomized, double-blind, placebo-controlled study in a 3-group, 2-sequence, 2-period cross-over design. The study is conducted according to the principles of ICH-GCP and the Declaration of Helsinki on the Phase I-Unit of the University Hospital Bonn. The primary endpoint is the pain intensity in the cold pressor test before and after the administration of 15 mg oxycodone or placebo. The pain intensity is compared between three study conditions: 32 healthy volunteers in each study arm will be treated either by an untrained study team (arm A), by a study team trained to maximize (arm B), or to minimize placebo responses (arm C). Neuroendocrine factors (alpha-amylase activity, salivary cortisol), characteristic traits (anxiety, depression, stress), and somatic reactions are analyzed as covariates of the pain perception.\n\nThe PINgPOng study will allow to answer the question whether and to what extent the behavior of a trained study team (neutral vs. maximize vs. minimize placebo responses) will differentially affect placebo responses in a setting of a highly standardized early clinical trial. The results will help to control the placebo effects by education of the clinical study team and to avoid unnecessary high placebo effects in clinical development.\n\nGerman Clinical Trials Register DRKS00013586 . Registered on December 22, 2017.", "doi": "10.1186/s13063-022-06436-0", "pmid": "35698101", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13063-022-06436-0"}], "notes": [], "created": "2022-06-20T18:18:10.247Z", "modified": "2022-06-20T18:18:10.298Z"}, {"entity": "publication", "iuid": "2ab7837ec8724d3f8643dda0d357dc01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ab7837ec8724d3f8643dda0d357dc01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ab7837ec8724d3f8643dda0d357dc01"}}, "title": "Factors Associated With the Decay of Anti-SARS-CoV-2 S1 IgG Antibodies Among Recipients of an Adenoviral Vector-Based AZD1222 and a Whole-Virion Inactivated BBV152 Vaccine.", "authors": [{"family": "Selvavinayagam", "given": "Sivaprakasam T", "initials": "ST"}, {"family": "Yong", "given": "Yean Kong", "initials": "YK"}, {"family": "Tan", "given": "Hong Yien", "initials": "HY"}, {"family": "Zhang", "given": "Ying", "initials": "Y"}, {"family": "Subramanian", "given": "Gurunathan", "initials": "G"}, {"family": "Rajeshkumar", "given": "Manivannan", "initials": "M"}, {"family": "Vasudevan", "given": "Kalaivani", "initials": "K"}, {"family": "Jayapal", "given": "Priyanka", "initials": "P"}, {"family": "Narayanasamy", "given": "Krishnasamy", "initials": "K"}, {"family": "Ramesh", "given": "Dinesh", "initials": "D"}, {"family": "Palani", "given": "Sampath", "initials": "S"}, {"family": "Larsson", "given": "Marie", "initials": "M"}, {"family": "Shankar", "given": "Esaki M", "initials": "EM"}, {"family": "Raju", "given": "Sivadoss", "initials": "S"}], "type": "journal article", "published": "2022-06-13", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "9", "pages": "887974", "issn-l": null}, "abstract": "The magnitude of protection conferred following recovery from COVID-19 or by vaccine administration, and the duration of protective immunity developed, remains ambiguous.\n\nWe investigated the factors associated with anti-SARS-CoV-2 S1 IgG decay in 519 individuals who recovered from COVID-19 illness or received COVID-19 vaccination with two commercial vaccines, viz., an adenoviral vector-based (AZD1222) and a whole-virion-based inactivated (BBV152) vaccine in Chennai, India from March to December 2021. Blood samples collected during regular follow-up post-infection/-vaccination were examined for anti-SARS-CoV-2 S1 IgG by a commercial automated chemiluminescent immunoassay (CLIA).\n\nAge and underlying comorbidities were the two variables that were independently associated with the development of a breakthrough infection. Individuals who were >60 years of age with underlying comorbid conditions (viz., hypertension, diabetes mellitus and cardiovascular disease) had a ~15 times and ~10 times greater odds for developing a breakthrough infection and hospitalization, respectively. The time elapsed since the first booster dose was associated with attrition in anti-SARS-CoV-2 IgG, where each month passed was associated with an ebb in the anti-SARS-CoV-2 IgG antibody levels by a coefficient of -6 units.\n\nOur findings advocate that the elderly with underlying comorbidities be administered with appropriate number of booster doses with AZD1222 and BBV152 against COVID-19.", "doi": "10.3389/fmed.2022.887974", "pmid": "35770011", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9235407"}], "notes": [], "created": "2022-08-19T05:32:02.750Z", "modified": "2023-06-19T15:34:18.898Z"}, {"entity": "publication", "iuid": "1f548fe422a845ef8b31a29baa318722", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1f548fe422a845ef8b31a29baa318722.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1f548fe422a845ef8b31a29baa318722"}}, "title": "Compliance of healthcare workers with the infection prevention and control guidance in tertiary care hospitals: quantitative findings from an explanatory sequential mixed-methods study in Bangladesh.", "authors": [{"family": "Salwa", "given": "Marium", "initials": "M", "orcid": "0000-0001-7869-3343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc49c7c98d32429387b54911fb024274.json"}}, {"family": "Haque", "given": "M Atiqul", "initials": "MA"}, {"family": "Islam", "given": "Syed Shariful", "initials": "SS"}, {"family": "Islam", "given": "Mohammad Tanvir", "initials": "MT"}, {"family": "Sultana", "given": "Sarmin", "initials": "S"}, {"family": "Khan", "given": "Md Maruf Haque", "initials": "MMH"}, {"family": "Moniruzzaman", "given": "Syed", "initials": "S"}], "type": "journal article", "published": "2022-06-13", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "6", "pages": "e054837", "issn-l": "2044-6055"}, "abstract": "To assess healthcare workers' (HCWs) compliance with the infection prevention and control (IPC) practices and identify the factors influencing this compliance using the Health Belief Model as the theoretical framework.\n\nQuantitative data from an explanatory sequential mixed-methods study were employed in this research.\n\nFrom 17 May to 30 August 2020, 604 physicians and nurses working at six randomly selected tertiary care facilities in Dhaka City in Bangladesh took part in this study.\n\nCompliance with the WHO's guidance on IPC measures, as well as the associated factors, was the primary outcome.\n\nA mean compliance score of 0.49 (\u00b10.25) was observed on a 0-1 scale. HCWs were most compliant with the medical mask wearing guidelines (81%) and were least compliant with the high-touch surface decontamination regulations (23%). Compliance with the IPC guidance was significantly associated with increasing age, female sex, working as a nurse, having non-communicable diseases and history of exposure to patients with COVID-19. Perceived benefits (B=0.039, 95% CI 0.001 to 0.076), self-efficacy (B=0.101, 95% CI 0.060 to 0.142) and cues to action (B=0.045, 95% CI 0.002 to 0.088) were positively associated with compliance. Compliance with IPC guidance was 0.061 times greater among participants who reported low perceived barriers compared with those with high perceived barriers.\n\nOverall, compliance with IPC guidance among HCWs was unsatisfactory. As self-efficacy exerted the greatest contribution to compliance, it should be emphasised in any endeavour to improve HCWs' IPC adherence. Such interventions should also focus on perceived barriers, including unreliability of the information sources, unsafe working places and unavailability of protective equipment and cues to action, including trust in the administration and availability of adequate IPC guidance.", "doi": "10.1136/bmjopen-2021-054837", "pmid": "35697439", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-054837"}], "notes": [], "created": "2022-06-20T18:18:49.066Z", "modified": "2022-06-20T18:18:49.122Z"}, {"entity": "publication", "iuid": "123bc7ea77f849f0ade0b6b2b402043a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/123bc7ea77f849f0ade0b6b2b402043a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/123bc7ea77f849f0ade0b6b2b402043a"}}, "title": "Cohort Profile: COVIDMENT: COVID-19 cohorts on mental health across six nations.", "authors": [{"family": "Unnarsd\u00f3ttir", "given": "Anna B\u00e1ra", "initials": "AB", "orcid": "0000-0002-6421-445X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2da21ebd675c4e329c47bf64bbc1578a.json"}}, {"family": "Lovik", "given": "Anik\u00f3", "initials": "A"}, {"family": "Fawns-Ritchie", "given": "Chloe", "initials": "C"}, {"family": "Ask", "given": "Helga", "initials": "H"}, {"family": "K\u00f5iv", "given": "Kadri", "initials": "K"}, {"family": "Hagen", "given": "Kristen", "initials": "K"}, {"family": "Didriksen", "given": "Maria", "initials": "M", "orcid": "0000-0002-4856-496X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b0efe911882405c9d53fd4a49797d07.json"}}, {"family": "Christoffersen", "given": "Lea Arregui Nordahl", "initials": "LAN"}, {"family": "Gar\u00f0arsson", "given": "Alexander Berg", "initials": "AB"}, {"family": "McIntosh", "given": "Andrew", "initials": "A"}, {"family": "K\u00e4hler", "given": "Anna K", "initials": "AK"}, {"family": "Campbell", "given": "Archie", "initials": "A", "orcid": "0000-0003-0198-5078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e2c09aef9a6458e857d323d5447423d.json"}}, {"family": "Hauksd\u00f3ttir", "given": "Arna", "initials": "A"}, {"family": "Erikstrup", "given": "Christian", "initials": "C", "orcid": "0000-0001-6551-6647", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f01382b51d3e46d8b8c9d74dbed3ce81.json"}}, {"family": "Mikkelsen", "given": "Dorte Helenius", "initials": "DH"}, {"family": "Altschul", "given": "Drew", "initials": "D", "orcid": "0000-0001-7053-4209", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a158612fcea406284cb809b0e9eb6ac.json"}}, {"family": "Thordardottir", "given": "Edda Bjork", "initials": "EB"}, {"family": "Frans", "given": "Emma Maria", "initials": "EM"}, {"family": "Kvale", "given": "Gerd", "initials": "G"}, {"family": "T\u00f3masson", "given": "Gunnar", "initials": "G"}, {"family": "Kariis", "given": "Hanna Maria", "initials": "HM"}, {"family": "J\u00f3nsd\u00f3ttir", "given": "Harpa Lind", "initials": "HL"}, {"family": "R\u00fanarsd\u00f3ttir", "given": "Harpa", "initials": "H"}, {"family": "Magn\u00fasd\u00f3ttir", "given": "Ingibj\u00f6rg", "initials": "I"}, {"family": "Eid", "given": "Jarle", "initials": "J"}, {"family": "Jakobsd\u00f3ttir", "given": "J\u00f3hanna", "initials": "J"}, {"family": "Nielsen", "given": "Kaspar Ren\u00e9", "initials": "KR"}, {"family": "Kaspersen", "given": "Kathrine Agerg\u00e5rd", "initials": "KA"}, {"family": "Milani", "given": "Lili", "initials": "L"}, {"family": "Trogstad", "given": "Lill-Iren Schou", "initials": "LS"}, {"family": "Yi", "given": "Lu", "initials": "L"}, {"family": "Bruun", "given": "Mie Topholm", "initials": "MT"}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF"}, {"family": "Magnus", "given": "Per Minor", "initials": "PM"}, {"family": "Shen", "given": "Qing", "initials": "Q", "orcid": "0000-0002-7214-4797", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/940144ccf8434a33a287ed4ff191be8d.json"}}, {"family": "Nesv\u00e5g", "given": "Ragnar", "initials": "R"}, {"family": "Brandlistuen", "given": "Ragnhild E", "initials": "RE", "orcid": "0000-0001-8054-0960", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/95d019cbc4714bc28863d5e26db63b1a.json"}}, {"family": "M\u00e4gi", "given": "Reedik", "initials": "R"}, {"family": "Ostrowski", "given": "Sisse Rye", "initials": "SR"}, {"family": "L\u00f8khammer", "given": "Solveig", "initials": "S"}, {"family": "Solem", "given": "Stian", "initials": "S"}, {"family": "Reichborn-Kjennerud", "given": "Ted", "initials": "T"}, {"family": "Hansen", "given": "Thomas Folkmann", "initials": "TF"}, {"family": "Werge", "given": "Thomas", "initials": "T"}, {"family": "Aspelund", "given": "Thor", "initials": "T", "orcid": "0000-0002-7998-5433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f3b5030190743e4b0ec0be05afb8fa8.json"}}, {"family": "Porteous", "given": "David J", "initials": "DJ"}, {"family": "Fang", "given": "Fang", "initials": "F", "orcid": "0000-0002-3310-6456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b0852465cd14239a25329b976172792.json"}}, {"family": "Lehto", "given": "Kelli", "initials": "K"}, {"family": "Andreassen", "given": "Ole A", "initials": "OA"}, {"family": "Pedersen", "given": "Ole Birger Vesterager", "initials": "OBV"}, {"family": "Hellard", "given": "Stephanie Le", "initials": "SL"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}], "type": "journal article", "published": "2022-06-13", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "volume": "51", "issue": "3", "pages": "e108-e122", "issn-l": "0300-5771"}, "abstract": null, "doi": "10.1093/ije/dyab234", "pmid": "35020900", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8690101"}, {"db": "pii", "key": "6432503"}], "notes": [], "created": "2022-01-13T20:55:36.883Z", "modified": "2023-02-13T18:37:59.354Z"}, {"entity": "publication", "iuid": "c1e7d453c52d48b7bdcca526b7537a96", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1e7d453c52d48b7bdcca526b7537a96.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1e7d453c52d48b7bdcca526b7537a96"}}, "title": "A retrospective cohort study of the effect of SARS-CoV-2 point of care rapid RT-PCR at the Emergency Department on targeted admission.", "authors": [{"family": "Mortazavi", "given": "Susanne E", "initials": "SE"}, {"family": "Inghammar", "given": "Malin", "initials": "M"}, {"family": "Christiansen", "given": "Claus", "initials": "C"}, {"family": "Pesola", "given": "Anne-Katrine", "initials": "AK"}, {"family": "Stenkilsson", "given": "Mikael", "initials": "M"}, {"family": "Paulsson", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1104-2727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0e37d2d03f64fe78a0e84f53922d29f.json"}}], "type": "journal article", "published": "2022-06-13", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "volume": "22", "issue": "1", "pages": "536", "issn-l": null}, "abstract": "To prevent nosocomial transmission of SARS-CoV-2, infection prevention control (IPC) measures are implemented for patients with symptoms compatible with COVID-19 until reliable test results are available. This delays admission to the most appropriate ward based on the medical condition. SARS-CoV-2 rapid antigen detection (RAD) tests and point-of-care (POC) rapid RT-PCR (VitaPCR) were introduced at emergency department (ED) at Sk\u00e5ne University Hospital, Sweden in late 2020, but the consequence on patient flow and targeted admission is unknown.\n\nPatients presenting at the emergency department of a referral hospital (N = 2940) between 13-Nov-2020 and 12-Jan-2021 were included. The study period was delimited into three periods by the introduction of RAD tests and the VitaPCR. Participant data was collected from hospital records, and outcome variables were Length-of-Stay (LoS), intrahospital transfers and targeted admission to COVID-19 ward.\n\nCompared to baseline (RT-PCR only), RAD tests reduced ED Length-of-Stay (LoS) for participants with positive tests. Negative VitaPCR results reduced mean hospital LoS by 1.5 (95% CI 0.3-2.7) days and admissions to COVID-19 wards from 34.5 (95% CI 28.9-40.5) to 14.7 (95% CI 11.1-19.1) per 100 admissions and reduced transfers between hospital wards in the first 5 days from 50.0 (95% CI 45.0-55.0) to 34.0 (95% CI 30.3-37.9) per 100 admissions.\n\nRAD tests enabled prompt detection of SARS-CoV-2 infection which had pronounced effects on LoS at the ED. Negative VitaPCR enabled cessation of IPC measures and a negative test was associated with increased targeted admissions, reduced intrahospital transfers and shorter LoS at the hospital.", "doi": "10.1186/s12879-022-07497-x", "pmid": "35692041", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12879-022-07497-x"}], "notes": [], "created": "2022-06-20T18:21:13.398Z", "modified": "2022-06-20T18:21:13.445Z"}, {"entity": "publication", "iuid": "6ae19140f6104a0983b7bb365708ad21", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ae19140f6104a0983b7bb365708ad21.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ae19140f6104a0983b7bb365708ad21"}}, "title": "aMMP-8 Oral Fluid PoC Test in Relation to Oral and Systemic Diseases.", "authors": [{"family": "Sorsa", "given": "Timo", "initials": "T"}, {"family": "Nwhator", "given": "Solomon Olusegun", "initials": "SO"}, {"family": "Sakellari", "given": "Dimitra", "initials": "D"}, {"family": "Grigoriadis", "given": "Andreas", "initials": "A"}, {"family": "Umeizudike", "given": "Kehinde Adesola", "initials": "KA"}, {"family": "Brandt", "given": "Ella", "initials": "E"}, {"family": "Keskin", "given": "Mutlu", "initials": "M"}, {"family": "Tervahartiala", "given": "Taina", "initials": "T"}, {"family": "P\u00e4rn\u00e4nen", "given": "Pirjo", "initials": "P"}, {"family": "Gupta", "given": "Shipra", "initials": "S"}, {"family": "Mohindra", "given": "Ritin", "initials": "R"}, {"family": "Bostanci", "given": "Nagihan", "initials": "N"}, {"family": "Buduneli", "given": "Nurcan", "initials": "N"}, {"family": "R\u00e4is\u00e4nen", "given": "Ismo Tapani", "initials": "IT"}], "type": "journal article", "published": "2022-06-10", "journal": {"title": "Front Oral Health", "issn": "2673-4842", "volume": "3", "pages": "897115", "issn-l": null}, "abstract": "The manuscript uses the previously published literature and highlights the benefits of active-matrix metalloproteinase (aMMP)-8 chairside/point-of-care (PoC) diagnostic tools as adjunctive measures in oral and systemic diseases. Previous studies suggest that as a biomarker, aMMP-8 is more precise than total MMP-8, MMP-9, MMP-2, MMP-3, MMP-13, MMP-7, MMP-1, calprotectin, myeloperoxidase (MPO), human neutrophil elastase (HNE), tissue inhibitor of matrix metalloproteinase (TIMP)-1, and bleeding of probing (BOP). Therefore, aMMP-8 could be implemented as the needed key biomarker for the new disease classification for both periodontitis and peri-implantitis. With a sensitivity to the tune of 75-85% and specificity in the range of 80-90%, lateral flow aMMP-8 PoC testing is comparable to catalytic protease activity assays for aMMP-8. The test can be further applied to estimate the glycemic status of an individual, to ascertain whether a person is at risk for COVID-19, in managing the oral side effects of radiotherapy carried in head and neck cancers, and in selected cases pertaining to reproductive health. In the future, aMMP-8 could find application as a potential systemic biomarker in diseases affecting the cardiovascular system, cancers, bacteremia, sepsis, diabetes, obesity, meningitis, as well as pancreatitis. The aMMP-8 PoCT is the first practical test in the emerging new dental clinical field, that is, oral clinical chemistry representing oral medicine, clinical chemistry, peri-implantology, and periodontology.", "doi": "10.3389/froh.2022.897115", "pmid": "35757444", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC9226345"}], "notes": [], "created": "2022-08-19T05:38:03.867Z", "modified": "2022-08-19T05:38:03.904Z"}, {"entity": "publication", "iuid": "55689f4f9c6540d888c7715314d2a70d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/55689f4f9c6540d888c7715314d2a70d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/55689f4f9c6540d888c7715314d2a70d"}}, "title": "Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination.", "authors": [{"family": "Scutelnic", "given": "Adrian", "initials": "A", "orcid": "0000-0001-9053-584X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c03804e51e6434382ecafddecb77bf0.json"}}, {"family": "Krzywicka", "given": "Katarzyna", "initials": "K"}, {"family": "Mbroh", "given": "Joshua", "initials": "J", "orcid": "0000-0002-0108-9161", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44e989b3250f44ba8d76c9998461cea2.json"}}, {"family": "van de Munckhof", "given": "Anita", "initials": "A"}, {"family": "S\u00e1nchez van Kammen", "given": "Mayte", "initials": "M", "orcid": "0000-0001-5614-9689", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae4f548088eb4c099837e35267755c0b.json"}}, {"family": "Aguiar de Sousa", "given": "Diana", "initials": "D"}, {"family": "Lindgren", "given": "Erik", "initials": "E", "orcid": "0000-0002-7628-5044", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e973b3c74ff4e5cba42da605a13bc61.json"}}, {"family": "Jood", "given": "Katarina", "initials": "K"}, {"family": "G\u00fcnther", "given": "Albrecht", "initials": "A"}, {"family": "Hiltunen", "given": "Sini", "initials": "S"}, {"family": "Putaala", "given": "Jukka", "initials": "J", "orcid": "0000-0002-6630-6104", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1930f3c097044b3a00d888744dab332.json"}}, {"family": "Tiede", "given": "Andreas", "initials": "A"}, {"family": "Maier", "given": "Frank", "initials": "F"}, {"family": "Kern", "given": "Rolf", "initials": "R"}, {"family": "Bartsch", "given": "Thorsten", "initials": "T"}, {"family": "Althaus", "given": "Katharina", "initials": "K"}, {"family": "Ciccone", "given": "Alfonso", "initials": "A"}, {"family": "Wiedmann", "given": "Markus", "initials": "M"}, {"family": "Skjelland", "given": "Mona", "initials": "M"}, {"family": "Medina", "given": "Antonio", "initials": "A"}, {"family": "Cuadrado-Godia", "given": "Elisa", "initials": "E"}, {"family": "Cox", "given": "Thomas", "initials": "T"}, {"family": "Aujayeb", "given": "Avinash", "initials": "A"}, {"family": "Raposo", "given": "Nicolas", "initials": "N", "orcid": "0000-0002-9152-4445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e10b5314fc94454b9c9c93eda229c6ff.json"}}, {"family": "Garambois", "given": "Katia", "initials": "K"}, {"family": "Payen", "given": "Jean-Francois", "initials": "JF"}, {"family": "Vuillier", "given": "Fabrice", "initials": "F"}, {"family": "Franchineau", "given": "Guillaume", "initials": "G"}, {"family": "Timsit", "given": "Serge", "initials": "S", "orcid": "0000-0003-0346-8576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7082d2f62ee47dd930342533b8841cf.json"}}, {"family": "Bougon", "given": "David", "initials": "D"}, {"family": "Dubois", "given": "Marie-C\u00e9cile", "initials": "MC"}, {"family": "Tawa", "given": "Audrey", "initials": "A"}, {"family": "Tracol", "given": "Clement", "initials": "C"}, {"family": "De Maistre", "given": "Emmanuel", "initials": "E"}, {"family": "Bonneville", "given": "Fabrice", "initials": "F"}, {"family": "Vayne", "given": "Caroline", "initials": "C"}, {"family": "Mengel", "given": "Annerose", "initials": "A"}, {"family": "Michalski", "given": "Dominik", "initials": "D"}, {"family": "Pelz", "given": "Johann", "initials": "J"}, {"family": "Wittstock", "given": "Matthias", "initials": "M"}, {"family": "Bode", "given": "Felix", "initials": "F"}, {"family": "Zimmermann", "given": "Julian", "initials": "J"}, {"family": "Schouten", "given": "Judith", "initials": "J"}, {"family": "Buture", "given": "Alina", "initials": "A"}, {"family": "Murphy", "given": "Sean", "initials": "S"}, {"family": "Palma", "given": "Vincenzo", "initials": "V", "orcid": "0000-0002-5178-7793", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/917551b107984115bd6544b5079a56d1.json"}}, {"family": "Negro", "given": "Alberto", "initials": "A"}, {"family": "Gutschalk", "given": "Alexander", "initials": "A"}, {"family": "Nagel", "given": "Simon", "initials": "S"}, {"family": "Schoenenberger", "given": "Silvia", "initials": "S", "orcid": "0000-0002-3348-6719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d55b87b9e7b94c0e936017c09d2f4113.json"}}, {"family": "Frisullo", "given": "Giovanni", "initials": "G"}, {"family": "Zanferrari", "given": "Carla", "initials": "C"}, {"family": "Grillo", "given": "Francesco", "initials": "F"}, {"family": "Giammello", "given": "Fabrizio", "initials": "F", "orcid": "0000-0002-2828-1305", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15fc1c416e354e57aa7e27beca2c5288.json"}}, {"family": "Martin", "given": "Mar Morin", "initials": "MM"}, {"family": "Cervera", "given": "Alvaro", "initials": "A"}, {"family": "Burrow", "given": "Jim", "initials": "J"}, {"family": "Garcia Esperon", "given": "Carlos", "initials": "C", "orcid": "0000-0001-8843-5890", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09472127f9334b0683793dd810154088.json"}}, {"family": "Chew", "given": "Beng Lim Alvin", "initials": "BLA"}, {"family": "Kleinig", "given": "Timothy J", "initials": "TJ"}, {"family": "Soriano", "given": "Cristina", "initials": "C"}, {"family": "Zimatore", "given": "Domenico S", "initials": "DS"}, {"family": "Petruzzellis", "given": "Marco", "initials": "M"}, {"family": "Elkady", "given": "Ahmed", "initials": "A"}, {"family": "Miranda", "given": "Miguel S", "initials": "MS"}, {"family": "Fernandes", "given": "Jo\u00e3o", "initials": "J"}, {"family": "Hellstr\u00f6m Vogel", "given": "\u00c5sl\u00f6g", "initials": "\u00c5"}, {"family": "Johansson", "given": "Elias", "initials": "E"}, {"family": "Philip", "given": "Anemon Puthuppallil", "initials": "AP"}, {"family": "Coutts", "given": "Shelagh B", "initials": "SB"}, {"family": "Bal", "given": "Simerpreet", "initials": "S"}, {"family": "Buck", "given": "Brian", "initials": "B"}, {"family": "Legault", "given": "Catherine", "initials": "C"}, {"family": "Blacquiere", "given": "Dylan", "initials": "D"}, {"family": "Katzberg", "given": "Hans D", "initials": "HD"}, {"family": "Field", "given": "Thalia S", "initials": "TS"}, {"family": "Dizonno", "given": "Vanessa", "initials": "V"}, {"family": "Gattringer", "given": "Thomas", "initials": "T", "orcid": "0000-0002-6065-6576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08316e418e954e04b10df2f202714764.json"}}, {"family": "Jacobi", "given": "Christian", "initials": "C"}, {"family": "Devroye", "given": "Annemie", "initials": "A"}, {"family": "Lemmens", "given": "Robin", "initials": "R"}, {"family": "Kristoffersen", "given": "Espen Saxhaug", "initials": "ES", "orcid": "0000-0002-8999-5424", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73de5b72e1914dc7a18152e46ac4befc.json"}}, {"family": "Bandettini di Poggio", "given": "Monica", "initials": "M"}, {"family": "Ghiasian", "given": "Masoud", "initials": "M"}, {"family": "Karapanayiotides", "given": "Theodoros", "initials": "T"}, {"family": "Chatterton", "given": "Sophie", "initials": "S"}, {"family": "Wronski", "given": "Miriam", "initials": "M"}, {"family": "Ng", "given": "Karl", "initials": "K"}, {"family": "Kahnis", "given": "Robert", "initials": "R"}, {"family": "Geeraerts", "given": "Thomas", "initials": "T"}, {"family": "Reiner", "given": "Peggy", "initials": "P"}, {"family": "Cordonnier", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-5697-6892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba080d69348640eb90fba290f58fee11.json"}}, {"family": "Middeldorp", "given": "Saskia", "initials": "S"}, {"family": "Levi", "given": "Marcel", "initials": "M"}, {"family": "van Gorp", "given": "Eric C M", "initials": "ECM"}, {"family": "van de Beek", "given": "Diederik", "initials": "D"}, {"family": "Brodard", "given": "Justine", "initials": "J"}, {"family": "Kremer Hovinga", "given": "Johanna A", "initials": "JA"}, {"family": "Kruip", "given": "Marieke J H A", "initials": "MJHA"}, {"family": "Tatlisumak", "given": "Turgut", "initials": "T"}, {"family": "Ferro", "given": "Jos\u00e9 M", "initials": "JM"}, {"family": "Coutinho", "given": "Jonathan M", "initials": "JM"}, {"family": "Arnold", "given": "Marcel", "initials": "M"}, {"family": "Poli", "given": "Sven", "initials": "S"}, {"family": "Heldner", "given": "Mirjam R", "initials": "MR", "orcid": "0000-0002-3594-2159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8280f8c6ea3a486abae8acc6aa491985.json"}}], "type": "journal article", "published": "2022-06-10", "journal": {"title": "Ann Neurol", "issn": "1531-8249", "issn-l": null}, "abstract": "Cerebral venous thrombosis caused by vaccine-induced immune thrombotic thrombocytopenia (VITT-CVT) is a rare adverse effect of adenovirus-based SARS-CoV-2 vaccines. In March 2021, after autoimmune pathogenesis of VITT was discovered, treatment recommendations were developed. These comprised immunomodulation, non-heparin anticoagulants, and avoidance of platelet transfusion. The aim of this study was to evaluate adherence to these recommendations and its association with mortality.\n\nWe used data from an international prospective registry of patients with CVT after adenovirus-based SARS-CoV-2 vaccination. We analyzed possible, probable or definite VITT-CVT cases included until 18 January 2022. Immunomodulation entailed administration of intravenous immunoglobulins and/or plasmapheresis.\n\n99 VITT-CVT patients from 71 hospitals in 17 countries were analyzed. Five of 38 (13%), 11/24 (46%), and 28/37 (76%) of patients diagnosed in March, April, and from May onwards, respectively, were treated in-line with VITT recommendations (p<0.001). Overall, treatment according to recommendations had no statistically significant influence on mortality (14/44 (32%) vs 29/55 (52%), adjusted OR 0.43 (95%CI 0.16-1.19)). However, patients who received immunomodulation had lower mortality (19/65 (29%) vs 24/34 (70%), adjusted OR 0.19 (95%CI 0.06-0.58)). Treatment with non-heparin anticoagulants instead of heparins was not associated with lower mortality (17/51 (33%) vs 13/35 (37%), adjusted OR 0.70 (95%CI 0.24-2.04)). Mortality was also not significantly influenced by platelet transfusion (17/27 (63%) vs 26/72 (36%), adjusted OR 2.19 (95%CI 0.74-6.54)).\n\nIn VITT-CVT patients, adherence to VITT treatment recommendations improved over time. Immunomodulation seems crucial for reducing mortality of VITT-CVT. This article is protected by copyright. All rights reserved.", "doi": "10.1002/ana.26431", "pmid": "35689346", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-20T19:24:43.957Z", "modified": "2022-06-20T19:24:55.082Z"}, {"entity": "publication", "iuid": "213af95fecd449bb8691218aa8923c26", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/213af95fecd449bb8691218aa8923c26.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/213af95fecd449bb8691218aa8923c26"}}, "title": "Seven domains of persisting problems after hospital-treated Covid-19 indicate a need for a multiprofessional rehabilitation approach.", "authors": [{"family": "Hellgren", "given": "Lovisa", "initials": "L"}, {"family": "Levi", "given": "Richard", "initials": "R"}, {"family": "Divanoglou", "given": "Anestis", "initials": "A"}, {"family": "Birberg-Thornberg", "given": "Ulrika", "initials": "U"}, {"family": "Samuelsson", "given": "Kersti", "initials": "K"}], "type": "journal article", "published": "2022-06-09", "journal": {"title": "J Rehabil Med", "issn": "1651-2081", "issn-l": null}, "abstract": "Objectives To identify domains of persisting problems at 4 months after discharge in patients previously hospitalized due to COVID-19, with focus on the subgroup of patients reporting symptoms to an extent indicative of rehabilitation needs. Design Ambidirectional observational cohort study. Patients All patients with a laboratory-confirmed COVID-19 diagnosis admitted to hospital in a Swedish healthcare region during 1/03-31/05, 2020. After exclusion, 94% of all survivors (n=433) participated in the study. Forty-three percent (n=185) of these reported persisting problems indicating rehabilitation needs and formed a subgroup. Methods Explorative factor analysis based on results from comprehensive telephone interviews covering persisting symptoms, including assessment of impact in daily life. Results Seven domains were identified comprising problems related to vision, cognition, mental fatigue, swallowing, voice, sensorimotor dysfunction and feeling anxious/depressed. The patients in the subgroup reported a median of 8 symptoms/limitations affecting everyday life, and two thirds reported symptoms/limitations in three or more domains. Conclusions Seven problem domains corresponding to specific modalities of rehabilitative interventions were identified. As a majority of patients reported problems from several domains, multiprofessional teams in post-COVID-19 rehabilitation is implicated. Screening of patients previously hospitalized due to COVID-19 should cover all seven domains.", "doi": "10.2340/jrm.v54.2434", "pmid": "35678268", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-20T19:29:58.865Z", "modified": "2022-06-20T19:29:58.879Z"}, {"entity": "publication", "iuid": "9350efb6514a4278a52e306bfaf61a81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9350efb6514a4278a52e306bfaf61a81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9350efb6514a4278a52e306bfaf61a81"}}, "title": "Pre-pandemic Physical Function and Social Network in Relation to COVID-19-Associated Depressive Burden in Older Adults in Sweden.", "authors": [{"family": "Triolo", "given": "Federico", "initials": "F", "orcid": "0000-0002-8732-0036", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a5b676e886a4723942f5bbf96a4e4d8.json"}}, {"family": "Saadeh", "given": "Marguerita", "initials": "M", "orcid": "0000-0002-2689-5784", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/324dbc9ae7ec4e5daab17e7fab6a183c.json"}}, {"family": "Sj\u00f6berg", "given": "Linnea", "initials": "L"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Welmer", "given": "Anna-Karin", "initials": "AK", "orcid": "0000-0001-5819-8724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d248c60e17b48cfa3ea3e90abf1e710.json"}}, {"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A"}, {"family": "Dekhtyar", "given": "Serhiy", "initials": "S", "orcid": "0000-0002-3062-4848", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9767e9072f6a44f6853b4001340eee97.json"}}], "type": "journal article", "published": "2022-06-09", "journal": {"title": "Innov Aging", "issn": "2399-5300", "volume": "6", "issue": "5", "pages": "igac041", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic, as well as the measures intended to limit its spread, have likely affected older adults' depressive burden. Good physical functioning and a rich social network may benefit older adults' mental health. We examined whether pre-pandemic physical functioning and social network were associated with depressive burden during the first wave of the COVID-19 pandemic in Stockholm, Sweden.\n\nA telephone assessment of depressive burden using the symptoms of sadness, anxiety, worrying, reduced sleep, and reduced appetite was conducted in May-September 2020 in 930 older adults from the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K), an ongoing population-based study. Objective measures of gait speed, muscle strength, and balance; and self-reports of social connections and support were collected in 2016-2019. Logistic models were adjusted for sociodemographic, clinical, lifestyle, and pandemic-related factors (loneliness, change in physical and social engagement, and experience of death due to COVID-19).\n\nOnly good muscle strength (odds ratio [OR]: 0.53; 95% confidence interval [CI]: 0.32-0.85; ref: poor strength, \u226517 s) and rich social support (OR: 0.67; 95% CI: 0.45-0.99; ref: poor support) exhibited an independent association with depressive burden, even after accounting for pandemic-related factors. A combination of good muscle strength and rich social support were associated with the greatest reduction in depressive burden (OR: 0.35; 95% CI: 0.18-0.66; ref: poor social support and poor muscle strength).\n\nPrepandemic social support and muscle strength could supply older adults with resilience against the depressive burden associated with the COVID-19 pandemic.", "doi": "10.1093/geroni/igac041", "pmid": "35837440", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "igac041"}, {"db": "pmc", "key": "PMC9273957"}], "notes": [], "created": "2022-08-12T08:58:51.049Z", "modified": "2022-08-12T08:58:51.257Z"}, {"entity": "publication", "iuid": "d4ae1d7ec5f7481e9c9095dfeaf9e0e5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4ae1d7ec5f7481e9c9095dfeaf9e0e5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4ae1d7ec5f7481e9c9095dfeaf9e0e5"}}, "title": "In Vivo Visualization and Quantification of Neutrophil Elastase in Lungs of COVID-19 Patients - A First-In-Human Positron Emission Tomography Study with 11C-GW457427.", "authors": [{"family": "Antoni", "given": "Gunnar", "initials": "G"}, {"family": "Lubberink", "given": "Mark", "initials": "M"}, {"family": "S\u00f6rensen", "given": "Jens", "initials": "J"}, {"family": "Lindstr\u00f6m", "given": "Elin", "initials": "E"}, {"family": "Elgland", "given": "Mathias", "initials": "M"}, {"family": "Eriksson", "given": "Olof", "initials": "O"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Wanhainen", "given": "Anders", "initials": "A"}, {"family": "Sigfridsson", "given": "Jonathan", "initials": "J"}, {"family": "Skorup", "given": "Paul", "initials": "P"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}], "type": "journal article", "published": "2022-06-09", "journal": {"title": "J Nucl Med", "issn": "1535-5667", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "COVID-19 can cause life-threatening lung-inflammation that is suggested to be mediated by neutrophils, whose effector mechanisms in COVID-19 is inexplicit. The aim of the present work is to evaluate a novel PET tracer for neutrophil elastase in COVID-19 patients and healthy controls. METHODS: In this open-label, First-In-Man study, four patients with hypoxia due to COVID-19 and two healthy controls were investigated with positron emission tomography (PET) using the new selective and specific neutrophil elastase PET-tracer [11C]GW457427 and [15O]water for the visualization and quantification of NE and perfusion in the lungs, respectively. RESULTS: [11C]GW457427 accumulated selectively in lung areas with ground-glass opacities on computed tomography characteristic of COVID-19 suggesting high levels on NE in these areas. In the same areas perfusion was severely reduced in comparison to healthy lung tissue as measured with [15O]water. CONCLUSION: The data suggests that NE may be responsible for the severe lung inflammation in COVID-19 patients and that inhibition of NE could potentially reduce the acute inflammatory process and improve the condition.", "doi": "10.2967/jnumed.122.263974", "pmid": "35680418", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "jnumed.122.263974"}], "notes": [], "created": "2022-06-20T19:28:49.814Z", "modified": "2022-08-19T12:36:21.106Z"}, {"entity": "publication", "iuid": "5251c54c69ab46da86cb75a58d411edb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5251c54c69ab46da86cb75a58d411edb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5251c54c69ab46da86cb75a58d411edb"}}, "title": "Age and sex effects on DNA methylation sites linked to genes implicated in severe COVID-19 and SARS-CoV-2 host cell entry.", "authors": [{"family": "Bohlin", "given": "Jon", "initials": "J", "orcid": "0000-0002-0992-1311", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20544b4db3c44a34b7f11715729e927d.json"}}, {"family": "Page", "given": "Christian M", "initials": "CM", "orcid": "0000-0002-1897-3666", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82db13fac79542f6be91580db5e15f64.json"}}, {"family": "Lee", "given": "Yunsung", "initials": "Y"}, {"family": "Pettersson", "given": "John H-O", "initials": "JH", "orcid": "0000-0001-6665-7492", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59b007230a6741888ef96de5e210276c.json"}}, {"family": "Jugessur", "given": "Astanand", "initials": "A"}, {"family": "Magnus", "given": "Per", "initials": "P"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}], "type": "journal article", "published": "2022-06-09", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "6", "pages": "e0269105", "issn-l": "1932-6203"}, "abstract": "Male sex and advanced age are associated with severe symptoms of COVID-19. Sex and age also exhibit substantial associations with genome-wide DNA methylation (DNAm) differences in humans. Using a random sample of Illumina EPIC-based genome-wide methylomes from peripheral whole blood of 1,976 parents, participating in The Norwegian Mother, Father and Child Cohort Study (MoBa), we explored whether DNAm in genes linked to SARS-CoV-2 host cell entry and to severe COVID-19 were associated with sex and age. This was carried out by testing 1,572 DNAm sites (CpGs) located near 45 genes for associations with age and sex. We found that DNAm in 281 and 231 of 1,572 CpGs were associated (pFDR<0.01) with sex and aging, respectively. CpGs linked to SARS-CoV-2 host cell entry genes were all associated with age and sex, except for the ACE2 receptor gene (located on the X-chromosome), which was only associated with sex (pFDR<0.01). Furthermore, we examined whether 1,487 autosomal CpGs associated with host-cell entry and severe COVID-19 were more or less associated with sex and age than what would be expected from the same number of randomly sampled genome-wide CpGs. We found that the CpGs associated with host-cell entry and severe COVID-19 were not more or less associated with sex (R2 = 0.77, p = 0.09) than the CpGs sampled from random genomic regions; age was actually found to be significantly less so (R2 = 0.36, p = 0.04). Hence, while we found wide-spread associations between sex and age at CpGs linked to genes implicated with SARS-CoV-2 host cell entry and severe COVID-19, the effect from the sum of these CpGs was not stronger than that from randomly sampled CpGs; for age it was significantly less so. These findings could suggest that advanced age and male sex may not be unsurmountable barriers for the SARS-CoV-2 virus to evolve increased infectiousness.", "doi": "10.1371/journal.pone.0269105", "pmid": "35679253", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-27385"}], "notes": [], "created": "2022-06-20T19:29:30.046Z", "modified": "2022-06-20T19:29:30.205Z"}, {"entity": "publication", "iuid": "d1dde5aa6de64fe2b824de24260f6fd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1dde5aa6de64fe2b824de24260f6fd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1dde5aa6de64fe2b824de24260f6fd0"}}, "title": "Synthesizing Stakeholders Perspectives on Online Psychological Interventions to Improve the Mental Health of the Italian Population during the COVID-19 Pandemic: An Online Survey Study.", "authors": [{"family": "Bertuzzi", "given": "Vanessa", "initials": "V", "orcid": "0000-0002-8541-5357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7abc069e75034b0e96265c7d48fb95a2.json"}}, {"family": "Semonella", "given": "Michelle", "initials": "M"}, {"family": "Castelnuovo", "given": "Gianluca", "initials": "G", "orcid": "0000-0003-2633-9822", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7463db589ae343e5ae6a7bc47a917c22.json"}}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Pietrabissa", "given": "Giada", "initials": "G"}], "type": "journal article", "published": "2022-06-08", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "12", "issn-l": null}, "abstract": "The COVID-19 pandemic is expected to significantly increase the prevalence of mental health problems, thus raising the need for psychological support interventions around the world. Online psychological interventions have already been shown to be an effective solution to promote psychological treatments. Nevertheless, planning and developing an online intervention, involving possible stakeholders, might facilitate the dissemination of, willingness to use, and success of the future intervention. This study aims to explore and compare the experiences that Italians living in Italy and abroad had with available support services during the COVID-19 pandemic, their needs, and attitudes, as well as possible barriers to online psychological interventions. A sample of 1024 Italians (F = 69.8%; mean age = 41.3; SD = 15.3) was recruited through social media platforms and personal contacts and they were asked to complete an online survey. Results showed that perceived psychological distress during the COVID-19 pandemic improved. In Europe, psychological support was delivered mainly in person (69.0%), while online interventions were primarily used in extra-European countries (57%). Then, only 44% of the total sample was interested in trying an online psychological intervention. Various advantages and disadvantages were defined by stakeholders: The main advantages were the reduction in geographical distances, economic reasons, and the reduction in the waiting list; The main disadvantages were problems with technology, low motivation of users, and privacy/safety reasons. These data made it possible to improve the knowledge regarding the views and attitudes that Italians have about online psychological interventions, and shed light on how to increase the uptake of digital health.", "doi": "10.3390/ijerph19127008", "pmid": "35742257", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19127008"}, {"db": "pmc", "key": "PMC9222987"}], "notes": [], "created": "2022-08-19T05:46:23.067Z", "modified": "2022-08-19T05:47:08.175Z"}, {"entity": "publication", "iuid": "f2fc843354aa430c8c48e3c815fcfd04", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f2fc843354aa430c8c48e3c815fcfd04.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f2fc843354aa430c8c48e3c815fcfd04"}}, "title": "Perceptions of delay when afflicted by an acute myocardial infarction during the first wave of the COVID-19 pandemic.", "authors": [{"family": "Granstr\u00f6m", "given": "Johanna", "initials": "J", "orcid": "0000-0002-3895-3179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/577ea5c47de04511a9b34e470c4d8b67.json"}}, {"family": "Lantz", "given": "Pontus", "initials": "P", "orcid": "0000-0003-4037-3904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6754b9ed3cd45129f456eab5c1e27c2.json"}}, {"family": "Lidin", "given": "Matthias", "initials": "M", "orcid": "0000-0002-2297-5621", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/99c36a92228c473dbebfce62830d2f35.json"}}, {"family": "Wahlstr\u00f6m", "given": "Maria", "initials": "M", "orcid": "0000-0003-4339-9202", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d169b22b55c4b11aa7b13f718f5f97b.json"}}, {"family": "Nymark", "given": "Carolin", "initials": "C", "orcid": "0000-0003-0891-6358", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26ae7dfc5d824e6ba7fda3c21ac670ef.json"}}], "type": "journal article", "published": "2022-06-08", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "issn-l": null}, "abstract": "To describe the perceptions of delay in medical care-seeking, when afflicted by an acute myocardial infarction (AMI) during the first wave of the pandemic.\n\nA qualitative descriptive study with an inductive approach. Fourteen semi-structured interviews were conducted, analysed by qualitative content analysis with a manifest approach. One category and six sub-categories emerged. The decision was reached when the health threat was perceived as critical, which made the earlier thoughts of the pandemic fade away. The risk of infection during medical visits caused fear of contracting the disease. This resulted in hesitation, neglect of symptoms, and avoidance of healthcare visits. Following recommendations from authorities and media about personal responsibility was motivated by fear, affecting the care-seeking.\n\nIt appears that the COVID-19 pandemic raised the threshold for deciding to seek medical care when presenting with an AMI. The pandemic led to increased patient delay due to several reasons among which fear of contracting the disease was prominent. The emotion of fear was related to the external threat to one's own health, due to COVID-19, and not fear of symptoms related to an AMI. The media reporting the healthcare system as overloaded increased insecurity and may have had an influence on delay.", "doi": "10.1093/eurjcn/zvac021", "pmid": "35672906", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6603987"}], "notes": [], "created": "2022-06-20T19:31:19.093Z", "modified": "2022-06-20T19:31:31.810Z"}, {"entity": "publication", "iuid": "35522c10f3744041bf3b7022dcbaeb94", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/35522c10f3744041bf3b7022dcbaeb94.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/35522c10f3744041bf3b7022dcbaeb94"}}, "title": "Pandemetrics: systematically assessing, monitoring, and controlling the evolution of a pandemic.", "authors": [{"family": "Barone", "given": "Stefano", "initials": "S", "orcid": "0000-0002-0339-8435", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7da10883e83473e955b7894ad37b7e8.json"}}, {"family": "Chakhunashvili", "given": "Alexander", "initials": "A"}], "type": "journal article", "published": "2022-06-08", "journal": {"title": "Qual Quant", "issn": "0033-5177", "pages": "1-23", "issn-l": null}, "abstract": "The still ongoing pandemic of SARS-CoV-2 virus and COVID-19 disease, affecting the population worldwide, has demonstrated the need of more accurate methodologies for assessing, monitoring, and controlling an outbreak of such devastating proportions. Authoritative attempts have been made in traditional fields of medicine (epidemiology, virology, infectiology) to address these shortcomings, mainly by relying on mathematical and statistical modeling. However, here, we propose approaching the methodological work from a different, and to some extent alternative, standpoint. Applied systematically, the concepts and tools of statistical engineering and quality management, developed not only in healthcare settings, but also in other scientific contexts, can be very useful in assessing, monitoring, and controlling pandemic events. We propose a methodology based on a set of tools and techniques, formulas, graphs, and tables to support the decision-making concerning the management of a pandemic like COVID-19. This methodological body is hereby named Pandemetrics. This name intends to emphasize the peculiarity of our approach to measuring, and graphically presenting the unique context of the COVID-19 pandemic.", "doi": "10.1007/s11135-022-01424-7", "pmid": "35694109", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "1424"}, {"db": "pmc", "key": "PMC9174634"}], "notes": [], "created": "2022-06-20T18:19:25.551Z", "modified": "2022-06-20T18:19:25.628Z"}, {"entity": "publication", "iuid": "b1d98ccebcc9452f911869284786638e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1d98ccebcc9452f911869284786638e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1d98ccebcc9452f911869284786638e"}}, "title": "Incidence and severity of SARS-CoV-2 infection in former Q fever patients as compared to the Dutch population, 2020-2021.", "authors": [{"family": "den Boogert", "given": "Elisabeth Maria", "initials": "EM", "orcid": "0000-0003-4514-0026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb49158a9d6e43429ef9622f2712b614.json"}}, {"family": "de Lange", "given": "Marit M A", "initials": "MMA"}, {"family": "Wielders", "given": "Cornelia C H", "initials": "CCH", "orcid": "0000-0002-2413-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5b6b985406d4b43ac66c6336dd1e4fe.json"}}, {"family": "Rietveld", "given": "Ariene", "initials": "A"}, {"family": "RIVM COVID-19 Surveillance and Epidemiology Team", "given": "", "initials": ""}, {"family": "Knol", "given": "Mirjam J", "initials": "MJ"}, {"family": "van Gageldonk-Lafeber", "given": "Arianne B", "initials": "AB"}], "type": "journal article", "published": "2022-06-08", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": "150", "pages": "e116", "issn-l": null}, "abstract": "Surveillance data shows a geographical overlap between the early coronavirus disease 2019 (COVID-19) pandemic and the past Q fever epidemic (2007-2010) in the Netherlands. We investigated the relationship between past Q fever and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in 2020/2021, using a retrospective matched cohort study.In January 2021, former Q fever patients received a questionnaire on demographics, SARS-CoV-2 test results and related hospital/intensive care unit (ICU) admissions. SARS-CoV-2 incidence with 95% confidence intervals (CI) in former Q fever patients and standardised incidence ratios (SIR) to compare to the age-standardised SARS-CoV-2 incidence in the general regional population were calculated.Among 890 former Q fever patients (response rate: 68%), 66 had a PCR-confirmed SARS-CoV-2 infection. Of these, nine (14%) were hospitalised and two (3%) were admitted to ICU. From February to June 2020 the SARS-CoV-2 incidence was 1573/100 000 (95% CI 749-2397) in former Q fever patients and 695/100 000 in the general population (SIR 2.26; 95% CI 1.24-3.80). The incidence was not significantly higher from September 2020 to February 2021.We found no sufficient evidence for a difference in SARS-CoV-2 incidence or an increased severity in former Q fever patients vs. the general population during the period with widespread SARS-CoV-2 testing availability (September 2020-February 2021). This indicates that former Q fever patients do not have a higher risk of SARS-CoV-2 infection.", "doi": "10.1017/S0950268822001029", "pmid": "35730315", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0950268822001029"}, {"db": "pmc", "key": "PMC9237486"}], "notes": [], "created": "2022-08-17T13:06:21.531Z", "modified": "2022-08-17T13:06:21.622Z"}, {"entity": "publication", "iuid": "c7207f8b8ccf44f4a2dd7d2a19c2e6b8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7207f8b8ccf44f4a2dd7d2a19c2e6b8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7207f8b8ccf44f4a2dd7d2a19c2e6b8"}}, "title": "COVID-19 news and the US equity market interactions: An inspection through econometric and machine learning lens.", "authors": [{"family": "Jana", "given": "Rabin K", "initials": "RK"}, {"family": "Ghosh", "given": "Indranil", "initials": "I"}, {"family": "Jawadi", "given": "Fredj", "initials": "F", "orcid": "0000-0003-3655-8391", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a38cc17b4a74cc895fcdb29dcd4a8b3.json"}}, {"family": "Uddin", "given": "Gazi Salah", "initials": "GS"}, {"family": "Sousa", "given": "Ricardo M", "initials": "RM"}], "type": "news", "published": "2022-06-08", "journal": {"title": "Ann Oper Res", "issn": "0254-5330", "issn-l": null, "volume": null, "issue": null, "pages": "1-22"}, "abstract": "This study investigates the impact of COVID-19 on the US equity market during the first wave of Coronavirus using a wide range of econometric and machine learning approaches. To this end, we use both daily data related to the US equity market sectors and data about the COVID-19 news over January 1, 2020-March 20, 2020. Accordingly, we show that at an early stage of the outbreak, global COVID-19s fears have impacted the US equity market even differently across sectors. Further, we also find that, as the pandemic gradually intensified its footprint in the US, local fears manifested by daily infections emerged more powerfully compared to its global counterpart in impairing the short-term dynamics of US equity markets.", "doi": "10.1007/s10479-022-04744-x", "pmid": "35698596", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "4744"}, {"db": "pmc", "key": "PMC9175525"}], "notes": [], "created": "2022-06-20T18:17:51.292Z", "modified": "2022-11-09T08:41:00.145Z"}, {"entity": "publication", "iuid": "6b3870582e3b46aca03e66295d52f284", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b3870582e3b46aca03e66295d52f284.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b3870582e3b46aca03e66295d52f284"}}, "title": "Understanding the Role and Impact of Poly (Ethylene Glycol) (PEG) on Nanoparticle Formulation: Implications for COVID-19 Vaccines.", "authors": [{"family": "Pad\u00edn-Gonz\u00e1lez", "given": "Esperanza", "initials": "E"}, {"family": "Lancaster", "given": "Pearl", "initials": "P"}, {"family": "Bottini", "given": "Massimo", "initials": "M"}, {"family": "Gasco", "given": "Paolo", "initials": "P"}, {"family": "Tran", "given": "Lang", "initials": "L"}, {"family": "Fadeel", "given": "Bengt", "initials": "B"}, {"family": "Wilkins", "given": "Terence", "initials": "T"}, {"family": "Monopoli", "given": "Marco P", "initials": "MP"}], "type": "journal article", "published": "2022-06-07", "journal": {"title": "Front Bioeng Biotechnol", "issn": "2296-4185", "volume": "10", "pages": "882363", "issn-l": null}, "abstract": "Poly (ethylene glycol) (PEG) is a widely used polymer in a variety of consumer products and in medicine. PEGylation refers to the conjugation of PEG to drugs or nanoparticles to increase circulation time and reduce unwanted host responses. PEG is viewed as being well-tolerated, but previous studies have identified anti-PEG antibodies and so-called pseudoallergic reactions in certain individuals. The increased use of nanoparticles as contrast agents or in drug delivery, along with the introduction of mRNA vaccines encapsulated in PEGylated lipid nanoparticles has brought this issue to the fore. Thus, while these vaccines have proven to be remarkably effective, rare cases of anaphylaxis have been reported, and this has been tentatively ascribed to the PEGylated carriers, which may trigger complement activation in susceptible individuals. Here, we provide a general overview of the use of PEGylated nanoparticles for pharmaceutical applications, and we discuss the activation of the complement cascade that might be caused by PEGylated nanomedicines for a better understanding of these immunological adverse reactions.", "doi": "10.3389/fbioe.2022.882363", "pmid": "35747492", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "882363"}, {"db": "pmc", "key": "PMC9209764"}], "notes": [], "created": "2022-08-19T05:41:06.956Z", "modified": "2022-08-19T05:41:06.990Z"}, {"entity": "publication", "iuid": "f0eee78f85084e239331766ec731525b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f0eee78f85084e239331766ec731525b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f0eee78f85084e239331766ec731525b"}}, "title": "Renin-Angiotensin Aldosterone System Inhibitors and COVID-19: A Systematic Review and Meta-Analysis Revealing Critical Bias Across a Body of Observational Research.", "authors": [{"family": "Loader", "given": "Jordan", "initials": "J", "orcid": "0000-0001-5623-7478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb84661f9eee4ff6aa5580311b1bf572.json"}}, {"family": "Taylor", "given": "Frances C", "initials": "FC"}, {"family": "Lampa", "given": "Erik", "initials": "E"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2c4588f000c470abf08f2e40852b6d1.json"}}], "type": "journal article", "published": "2022-06-07", "journal": {"title": "J Am Heart Assoc", "issn": "2047-9980", "volume": "11", "issue": "11", "pages": "e025289", "issn-l": null}, "abstract": "Background Renin-angiotensin aldosterone system (RAAS) inhibitor-COVID-19 studies, observational in design, appear to use biased methods that can distort the interaction between RAAS inhibitor use and COVID-19 risk. This study assessed the extent of bias in that research and reevaluated RAAS inhibitor-COVID-19 associations in studies without critical risk of bias. Methods and Results Searches were performed in MEDLINE, EMBASE, and CINAHL databases (December 1, 2019 to October 21, 2021) identifying studies that compared the risk of infection and/or severe COVID-19 outcomes between those using or not using RAAS inhibitors (ie, angiotensin-converting enzyme inhibitors or angiotensin II type-I receptor blockers). Weighted hazard ratios (HR) and 95% CIs were extracted and pooled in fixed-effects meta-analyses, only from studies without critical risk of bias that assessed severe COVID-19 outcomes. Of 169 relevant studies, 164 had critical risks of bias and were excluded. Ultimately, only two studies presented data relevant to the meta-analysis. In 1 351 633 people with uncomplicated hypertension using a RAAS inhibitor, calcium channel blocker, or thiazide diuretic in monotherapy, the risk of hospitalization (angiotensin-converting enzyme inhibitor: HR, 0.76; 95% CI, 0.66-0.87; P<0.001; angiotensin II type-I receptor blockers: HR, 0.86; 95% CI, 0.77-0.97; P=0.015) and intubation or death (angiotensin-converting enzyme inhibitor: HR, 0.64; 95% CI, 0.48-0.85; P=0.002; angiotensin II type-I receptor blockers: HR, 0.74; 95% CI, 0.58-0.95; P=0.019) with COVID-19 was lower in those using a RAAS inhibitor. However, these protective effects are probably not clinically relevant. Conclusions This study reveals the critical risk of bias that exists across almost an entire body of COVID-19 research, raising an important question: Were research methods and/or peer-review processes temporarily weakened during the surge of COVID-19 research or is this lack of rigor a systemic problem that also exists outside pandemic-based research? Registration URL: www.crd.york.ac.uk/prospero/; Unique identifier: CRD42021237859.", "doi": "10.1161/JAHA.122.025289", "pmid": "35624081", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T17:43:48.128Z", "modified": "2022-06-21T17:44:16.895Z"}, {"entity": "publication", "iuid": "63b3d52cc7054ddc857aefb8e82a27ec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63b3d52cc7054ddc857aefb8e82a27ec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63b3d52cc7054ddc857aefb8e82a27ec"}}, "title": "COVID-19 pandemic is associated with increased sleep disturbances and mental health symptoms but not help-seeking: a cross-sectional nation-wide study.", "authors": [{"family": "Moreno", "given": "Claudia Roberta de Castro", "initials": "CRC", "orcid": "0000-0003-1839-9673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a22ff4be344d4bb7941b0b74d4636afe.json"}}, {"family": "Conway", "given": "Silvia G", "initials": "SG"}, {"family": "Assis", "given": "M\u00e1rcia", "initials": "M"}, {"family": "Genta", "given": "Pedro Rodrigues", "initials": "PR"}, {"family": "Pachito", "given": "Daniela V", "initials": "DV"}, {"family": "Tavares", "given": "Almir", "initials": "A"}, {"family": "Sguillar", "given": "Danilo A", "initials": "DA"}, {"family": "Moreira", "given": "Gustavo", "initials": "G"}, {"family": "Drager", "given": "Luciano F", "initials": "LF"}, {"family": "Bacelar", "given": "Andrea", "initials": "A"}], "type": "journal article", "published": "2022-06-07", "journal": {"title": "Sleep Sci", "issn": "1984-0659", "volume": "15", "issue": "1", "pages": "1-7", "issn-l": null}, "abstract": "This study aimed firstly to describe sleep-related and mental health symptoms before and during the COVID-19 pandemic in a national-wide sample and, secondly, to verify attitudes towards help-seeking to treat these symptoms.\n\nData were collected through an online questionnaire sent through the Brazilian Sleep Association's social media. The questionnaire included sociodemographic and sleep aspects questions currently and before the pandemic period. In addition, the survey addressed current and previous anxiety, depression, and burnout symptoms. The outcome help-seeking was addressed in the questionnaire as well by a single question asked when the participant reported mental or sleep problems.\n\nThe study covered 6,360 participants, mean age 43.5 years (SD=14.3), 76.7% female and 63.7% with undergraduate or higher degree filled out the survey. Seventy percent of participants reported sleep disturbances and 80% reported symptoms of anxiety during the pandemic. Help-seeking behavior was found only in one third of them. Hours of sleep reduced from 7.12 to 6.2h, which can be related with the increase in 28.2% of dissatisfaction with sleep duration during the pandemic. The highest frequency of complaints related to sleep was difficulty to fall asleep three or more times a week (going from 27.6% before the pandemic to 58.9% during the pandemic; p<0.001). Moreover, it was observed that help-seeking was more prevalent in men than women, and more in younger participants than in older ones.\n\nThere was an increase of sleep and mental self-reported problems during the pandemic, which was not followed by help-seeking.", "doi": "10.5935/1984-0063.20220027", "pmid": "35662970", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9153976"}], "notes": [], "created": "2022-06-20T19:35:14.867Z", "modified": "2022-06-20T19:35:14.966Z"}, {"entity": "publication", "iuid": "a4bae0fecd924d40a9766319b6c23c26", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a4bae0fecd924d40a9766319b6c23c26.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a4bae0fecd924d40a9766319b6c23c26"}}, "title": "Associations between integrase strand-transfer inhibitors and cardiovascular disease in people living with HIV: a multicentre prospective study from the RESPOND cohort consortium.", "authors": [{"family": "Neesgaard", "given": "Bastian", "initials": "B"}, {"family": "Greenberg", "given": "Lauren", "initials": "L"}, {"family": "Mir\u00f3", "given": "Jose M", "initials": "JM"}, {"family": "Grabmeier-Pfistershammer", "given": "Katharina", "initials": "K"}, {"family": "Wandeler", "given": "Gilles", "initials": "G"}, {"family": "Smith", "given": "Colette", "initials": "C"}, {"family": "De Wit", "given": "St\u00e9phane", "initials": "S"}, {"family": "Wit", "given": "Ferdinand", "initials": "F"}, {"family": "Pelchen-Matthews", "given": "Annegret", "initials": "A"}, {"family": "Mussini", "given": "Cristina", "initials": "C"}, {"family": "Castagna", "given": "Antonella", "initials": "A"}, {"family": "Pradier", "given": "Christian", "initials": "C"}, {"family": "d'Arminio Monforte", "given": "Antonella", "initials": "A"}, {"family": "Vehreschild", "given": "J\u00f6rg J", "initials": "JJ"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Anne", "given": "Alain V", "initials": "AV"}, {"family": "Carr", "given": "Andrew", "initials": "A"}, {"family": "Bansi-Matharu", "given": "Loveleen", "initials": "L"}, {"family": "Lundgren", "given": "Jens D", "initials": "JD"}, {"family": "Garges", "given": "Harmony", "initials": "H"}, {"family": "Rogatto", "given": "Felipe", "initials": "F"}, {"family": "Zangerle", "given": "Robert", "initials": "R"}, {"family": "G\u00fcnthard", "given": "Huldrych F", "initials": "HF"}, {"family": "Rasmussen", "given": "Line D", "initials": "LD"}, {"family": "Necsoi", "given": "Coca", "initials": "C"}, {"family": "van der Valk", "given": "Marc", "initials": "M"}, {"family": "Menozzi", "given": "Marianna", "initials": "M"}, {"family": "Muccini", "given": "Camilla", "initials": "C"}, {"family": "Peters", "given": "Lars", "initials": "L"}, {"family": "Mocroft", "given": "Amanda", "initials": "A"}, {"family": "Ryom", "given": "Lene", "initials": "L"}], "type": "journal article", "published": "2022-06-07", "journal": {"title": "Lancet HIV", "issn": "2352-3018", "issn-l": null}, "abstract": "Although associations between older antiretroviral drug classes and cardiovascular disease in people living with HIV are well described, there is a paucity of data regarding a possible association with integrase strand-transfer inhibitors (INSTIs). We investigated whether exposure to INSTIs was associated with an increased incidence of cardiovascular disease.\n\nRESPOND is a prospective, multicentre, collaboration study between 17 pre-existing European and Australian cohorts and includes more than 32 000 adults living with HIV in clinical care after Jan 1, 2012. Individuals were eligible for inclusion in these analyses if they were older than 18 years, had CD4 cell counts and HIV viral load measurements in the 12 months before or within 3 months after baseline (latest of cohort enrolment or Jan 1, 2012), and had no exposure to INSTIs before baseline. These individuals were subsequently followed up to the earliest of the first cardiovascular disease event (ie, myocardial infarction, stroke, or invasive cardiovascular procedure), last follow-up, or Dec 31, 2019. We used multivariable negative binomial regression to assess associations between cardiovascular disease and INSTI exposure (0 months [no exposure] vs >0 to 6 months, >6 to 12 months, >12 to 24 months, >24 to 36 months, and >36 months), adjusted for cardiovascular risk factors. RESPOND is registered with ClinicalTrials.gov, NCT04090151, and is ongoing.\n\n29 340 people living with HIV were included in these analyses, of whom 7478 (25\u00b75%) were female, 21 818 (74\u00b74%) were male, and 44 (<1%) were transgender, with a median age of 44\u00b73 years (IQR 36\u00b72-51\u00b73) at baseline. As of Dec 31, 2019, 14 000 (47\u00b77%) of 29 340 participants had been exposed to an INSTI. During a median follow-up of 6\u00b716 years (IQR 3\u00b787-7\u00b752; 160 252 person-years), 748 (2\u00b75%) individuals had a cardiovascular disease event (incidence rate of 4\u00b767 events [95% CI 4\u00b734-5\u00b701] per 1000 person-years of follow-up). The crude cardiovascular disease incidence rate was 4\u00b719 events (3\u00b783-4\u00b757) per 1000 person-years in those with no INSTI exposure, which increased to 8\u00b746 events (6\u00b758-10\u00b771) per 1000 person-years in those with more than 0 months to 6 months of exposure, and gradually decreased with increasing length of exposure, until it decreased to similar levels of no exposure at more than 24 months of exposure (4\u00b725 events [2\u00b789-6\u00b704] per 1000 person-years among those with >24 to 36 months of exposure). Compared with those with no INSTI exposure, the risk of cardiovascular disease was increased in the first 24 months of INSTI exposure and thereafter decreased to levels similar to those never exposed (>0 to 6 months of exposure: adjusted incidence rate ratio of 1\u00b785 [1\u00b744-2\u00b739]; >6 to 12 months of exposure: 1\u00b719 [0\u00b784-1\u00b768]; >12 to 24 months of exposure: 1\u00b746 [1\u00b713-1\u00b788]; >24 to 36 months of exposure: 0\u00b789 [0\u00b762-1\u00b729]; and >36 months of exposure: 0\u00b796 [0\u00b769-1\u00b733]; p<0\u00b70001).\n\nAlthough the potential for unmeasured confounding and channelling bias cannot fully be excluded, INSTIs initiation was associated with an early onset, excess incidence of cardiovascular disease in the first 2 years of exposure, after accounting for known cardiovascular disease risk factors. These early findings call for analyses in other large studies, and the potential underlying mechanisms explored further.\n\nThe CHU St Pierre Brussels HIV Cohort, The Austrian HIV Cohort Study, The Australian HIV Observational Database, The AIDS Therapy Evaluation in the Netherlands National Observational HIV cohort, The EuroSIDA cohort, The Frankfurt HIV Cohort Study, The Georgian National AIDS Health Information System, The Nice HIV Cohort, The ICONA Foundation, The Modena HIV Cohort, The PISCIS Cohort Study, The Swiss HIV Cohort Study, The Swedish InfCare HIV Cohort, The Royal Free HIV Cohort Study, The San Raffaele Scientific Institute, The University Hospital Bonn HIV Cohort and The University of Cologne HIV Cohorts, ViiV Healthcare, and Gilead Sciences.", "doi": "10.1016/S2352-3018(22)00094-7", "pmid": "35688166", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2352-3018(22)00094-7"}, {"db": "ClinicalTrials.gov", "key": "NCT04090151"}], "notes": [], "created": "2022-06-20T19:25:55.874Z", "modified": "2022-06-20T19:25:55.914Z"}, {"entity": "publication", "iuid": "b7d2e056b4524e9ba6c651f6f889d7fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b7d2e056b4524e9ba6c651f6f889d7fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b7d2e056b4524e9ba6c651f6f889d7fc"}}, "title": "Adaptive governance of urban green spaces across Latin America ---Insights amid COVID-19.", "authors": [{"family": "Sainz-Santamaria", "given": "Jaime", "initials": "J"}, {"family": "Martinez-Cruz", "given": "Adan L", "initials": "AL"}], "type": "journal article", "published": "2022-06-07", "journal": {"title": "Urban For Urban Green", "issn": "1618-8667", "issn-l": null, "volume": null, "issue": null, "pages": "127629"}, "abstract": "Urban green spaces' well documented role as a hub for physical and mental health was enhanced by restrictions to mobility issued worldwide as a response to COVID-19. In this context, managers of urban green spaces (UGS) were prompted to provide controlled access under impromptu safety protocols. This unprecedented challenge required planning and operational strengths reflecting flexibility, innovation and learning. These management features are essential for an adaptive governance -an underdeveloped research topic within the study of UGS. Using eighteen semi-structured interviews from six countries, we analyze adaptive governance as reflected by UGS managers' responses across Latin America -a region where access to UGS is a matter of public health and of environmental justice. We document responses that can be categorized based on the governance arrangement in place. On one hand, both polycentric and dedicated-management governances have been able to learn through piloting ideas, adapting personnel roles and the function of UGS infrastructure, and adjusting their decision-making process. On the other hand, managers within municipal public services areas -the most prevalent governance arrangement across Latin America- report difficulty to adapt -likely due to their dependence on political will, lack of continuity due limited autonomy, insufficient budgets, absence of formal paths to self-funding, shortage of technical know-how, and insufficient citizens' involvement. We discuss implications of UGS adaptive governance in terms of capacity to deal with future public health, climate-related or other types of shocks.", "doi": "10.1016/j.ufug.2022.127629", "pmid": "35692898", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S1618-8667(22)00172-8"}, {"db": "pmc", "key": "PMC9173828"}], "notes": [], "created": "2022-06-20T18:19:42.797Z", "modified": "2022-11-09T08:41:42.833Z"}, {"entity": "publication", "iuid": "a01b9a875b2a471eb4148059febe5472", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a01b9a875b2a471eb4148059febe5472.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a01b9a875b2a471eb4148059febe5472"}}, "title": "I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations.", "authors": [{"family": "Files", "given": "Daniel Clark", "initials": "DC", "orcid": "0000-0002-1595-4080", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7921bbd010a24850ba0c57d0e591d5ba.json"}}, {"family": "Matthay", "given": "Michael A", "initials": "MA"}, {"family": "Calfee", "given": "Carolyn S", "initials": "CS"}, {"family": "Aggarwal", "given": "Neil R", "initials": "NR"}, {"family": "Asare", "given": "Adam L", "initials": "AL"}, {"family": "Beitler", "given": "Jeremy R", "initials": "JR"}, {"family": "Berger", "given": "Paul A", "initials": "PA"}, {"family": "Burnham", "given": "Ellen L", "initials": "EL"}, {"family": "Cimino", "given": "George", "initials": "G"}, {"family": "Coleman", "given": "Melissa H", "initials": "MH"}, {"family": "Crippa", "given": "Alessio", "initials": "A"}, {"family": "Discacciati", "given": "Andrea", "initials": "A"}, {"family": "Gandotra", "given": "Sheetal", "initials": "S", "orcid": "0000-0002-5475-9704", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/875d45a15b964498992ab468206dd2fa.json"}}, {"family": "Gibbs", "given": "Kevin W", "initials": "KW"}, {"family": "Henderson", "given": "Paul T", "initials": "PT"}, {"family": "Ittner", "given": "Caroline A G", "initials": "CAG"}, {"family": "Jauregui", "given": "Alejandra", "initials": "A"}, {"family": "Khan", "given": "Kashif T", "initials": "KT"}, {"family": "Koff", "given": "Jonathan L", "initials": "JL"}, {"family": "Lang", "given": "Julie", "initials": "J"}, {"family": "LaRose", "given": "Mary", "initials": "M"}, {"family": "Levitt", "given": "Joe", "initials": "J"}, {"family": "Lu", "given": "Ruixiao", "initials": "R"}, {"family": "McKeehan", "given": "Jeffrey D", "initials": "JD"}, {"family": "Meyer", "given": "Nuala J", "initials": "NJ"}, {"family": "Russell", "given": "Derek W", "initials": "DW", "orcid": "0000-0002-2716-1344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13774f6125b448b1a63423f9f5fa1cab.json"}}, {"family": "Thomas", "given": "Karl W", "initials": "KW"}, {"family": "Eklund", "given": "Martin", "initials": "M"}, {"family": "Esserman", "given": "Laura J", "initials": "LJ"}, {"family": "Liu", "given": "Kathleen D", "initials": "KD"}, {"family": "ISPY COVID Adaptive Platform Trial Network", "given": "", "initials": ""}, {"family": "undefined", "given": "", "initials": ""}], "type": "journal article", "published": "2022-06-06", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "6", "pages": "e060664", "issn-l": "2044-6055"}, "abstract": "The COVID-19 pandemic brought an urgent need to discover novel effective therapeutics for patients hospitalised with severe COVID-19. The Investigation of Serial studies to Predict Your Therapeutic Response with Imaging And moLecular Analysis (ISPY COVID-19 trial) was designed and implemented in early 2020 to evaluate investigational agents rapidly and simultaneously on a phase 2 adaptive platform. This manuscript outlines the design, rationale, implementation and challenges of the ISPY COVID-19 trial during the first phase of trial activity from April 2020 until December 2021.\n\nThe ISPY COVID-19 Trial is a multicentre open-label phase 2 platform trial in the USA designed to evaluate therapeutics that may have a large effect on improving outcomes from severe COVID-19. The ISPY COVID-19 Trial network includes academic and community hospitals with significant geographical diversity across the country. Enrolled patients are randomised to receive one of up to four investigational agents or a control and are evaluated for a family of two primary outcomes-time to recovery and mortality. The statistical design uses a Bayesian model with 'stopping' and 'graduation' criteria designed to efficiently discard ineffective therapies and graduate promising agents for definitive efficacy trials. Each investigational agent arm enrols to a maximum of 125 patients per arm and is compared with concurrent controls. As of December 2021, 11 investigational agent arms had been activated, and 8 arms were complete. Enrolment and adaptation of the trial design are ongoing.\n\nISPY COVID-19 operates under a central institutional review board via Wake Forest School of Medicine IRB00066805. Data generated from this trial will be reported in peer-reviewed medical journals.\n\nNCT04488081.", "doi": "10.1136/bmjopen-2021-060664", "pmid": "35667714", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-060664"}, {"db": "ClinicalTrials.gov", "key": "NCT04488081"}], "notes": [], "created": "2022-06-20T19:34:00.059Z", "modified": "2022-06-20T19:34:14.060Z"}, {"entity": "publication", "iuid": "cac43704a1494c379d09ea40681613e4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cac43704a1494c379d09ea40681613e4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cac43704a1494c379d09ea40681613e4"}}, "title": "Critical care nurses' perception of moral distress in intensive care during the COVID-19 pandemic - A pilot study.", "authors": [{"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Nordin", "given": "Anna", "initials": "A"}, {"family": "Engstr\u00f6m", "given": "\u00c5sa", "initials": "\u00c5"}], "type": "journal article", "published": "2022-06-06", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "pages": "103279", "issn-l": null}, "abstract": "To describe critical care nurses' perception of moral distress during the second year of the COVID-19 pandemic.\n\nA cross-sectional study involving a questionnaire was conducted. Participants responded to the Italian version of the Moral Distress Scale-Revised, which consists of 14 items divided in dimensions Futile care (three items), Ethical misconduct (five items), Deceptive communication (three items) and Poor teamwork (three items). For each item, participants were also invited to write about their experiences and participants' intention to leave a position now was measured by a dichotomous question. The data were analysed with descriptive statistics and qualitative content analysis. The study followed the checklist (CHERRIES) for reporting results of internet surveys.\n\nCritical care nurses (n = 71) working in Swedish adult intensive care units.\n\nCritical care nurses experienced the intensity of moral distress as the highest when no one decided to withdraw ventilator support to a hopelessly ill person (Futile care), and when they had to assist another physician or nurse who provided incompetent care (Poor teamwork). Thirty-nine percent of critical care nurses were considering leaving their current position because of moral distress.\n\nDuring the COVID-19 pandemic, critical care nurses, due to their education and experience of intensive care nursing, assume tremendous responsibility for critically ill patients. Throughout, communication within the intensive care team seems to have a bearing on the degree of moral distress. Improvements in communication and teamwork are needed to reduce moral distress among critical care nurses.", "doi": "10.1016/j.iccn.2022.103279", "pmid": "35688753", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(22)00082-9"}], "notes": [], "created": "2022-06-20T19:25:13.462Z", "modified": "2022-06-20T19:25:25.362Z"}, {"entity": "publication", "iuid": "6ebf9ae4745f4cbf92e3d685d0c1e517", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ebf9ae4745f4cbf92e3d685d0c1e517.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ebf9ae4745f4cbf92e3d685d0c1e517"}}, "title": "Angiopoietin-2 Inhibition of Thrombomodulin-Mediated Anticoagulation-A Novel Mechanism That May Contribute to Hypercoagulation in Critically Ill COVID-19 Patients.", "authors": [{"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Fromell", "given": "Karin", "initials": "K", "orcid": "0000-0001-8905-8791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9342eb4305954aba853bdf3a8153ab67.json"}}, {"family": "Larsson", "given": "Anders", "initials": "A", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2be858ab604743b72383dfdcd14689.json"}}, {"family": "Persson", "given": "Barbro", "initials": "B"}, {"family": "Nilsson", "given": "Bo", "initials": "B"}, {"family": "Quaggin", "given": "Susan E", "initials": "SE"}, {"family": "Betsholtz", "given": "Christer", "initials": "C"}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Jeansson", "given": "Marie", "initials": "M", "orcid": "0000-0003-1075-8563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae2c63715b0f4a5b8127552ab84a1bf3.json"}}], "type": "journal article", "published": "2022-06-06", "journal": {"title": "Biomedicines", "issn": "2227-9059", "issn-l": null, "volume": "10", "issue": "6", "pages": null}, "abstract": "Hypercoagulation and endothelial dysfunction play central roles in severe forms of COVID-19 infections, but the molecular mechanisms involved are unclear. Increased plasma levels of the inflammatory cytokine and TIE2 receptor antagonist Angiopoietin-2 were reported in severely ill COVID-19 patients. In vitro experiments suggest that Angiopoietin-2 bind and inhibits thrombomodulin. Thrombomodulin is expressed on the luminal surface of endothelial cells where it is an important member of the intrinsic anticoagulant pathway through activation of protein C. Using clinical data, mouse models, and in vitro assays, we tested if Angiopoietin-2 plays a causal role in COVID-19-associated hypercoagulation through direct inhibition of thrombin/thrombomodulin-mediated physiological anticoagulation. Angiopoietin-2 was measured in 61 patients at admission, and after 10 days in the 40 patients remaining in the ICU. We found that Angiopoietin-2 levels were increased in COVID-19 patients in correlation with disease severity, hypercoagulation, and mortality. In support of a direct effect of Angiopoietin-2 on coagulation, we found that injected Angiopoietin-2 in mice associated to thrombomodulin and resulted in a shortened tail bleeding time, decreased circulating levels of activated protein C, and increased plasma thrombin/antithrombin complexes. Conversely, bleeding time was increased in endothelial-specific Angiopoietin-2 knockout mice, while knockout of Tie2 had no effect on tail bleeding. Using in vitro assays, we found that Angiopoietin-2 inhibited thrombomodulin-mediated anticoagulation and protein C activation in human donor plasma. Our data suggest a novel in vivo mechanism for Angiopoietin-2 in COVID-19-associated hypercoagulation, implicating that Angiopoietin-2 inhibitors may be effective in the treatment of hypercoagulation in severe COVID-19 infection.", "doi": "10.3390/biomedicines10061333", "pmid": "35740360", "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "biomedicines10061333"}, {"db": "pmc", "key": "PMC9220312"}, {"db": "URL", "key": "https://doi.org/10.17044/scilifelab.14229410", "description": "https://doi.org/10.17044/scilifelab.14229410"}], "notes": [], "created": "2022-08-19T05:49:08.807Z", "modified": "2022-08-19T12:36:44.560Z"}, {"entity": "publication", "iuid": "8a0ac9252cfb436fbe1fe3f923db30de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a0ac9252cfb436fbe1fe3f923db30de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a0ac9252cfb436fbe1fe3f923db30de"}}, "title": "Hospital bed occupancy for COVID-19 or with SARS-CoV-2 infection in a Swedish county during the omicron wave.", "authors": [{"family": "Spreco", "given": "Armin", "initials": "A"}, {"family": "Andersson", "given": "Christer", "initials": "C"}, {"family": "Sj\u00f6dahl", "given": "Rune", "initials": "R"}, {"family": "Dahlstr\u00f6m", "given": "\u00d6rjan", "initials": "\u00d6"}, {"family": "Timpka", "given": "Toomas", "initials": "T", "orcid": "0000-0001-6049-5402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebcb4fac20f845a4bd9eaa4bf1660ebb.json"}}], "type": "letter", "published": "2022-06-05", "journal": {"title": "Influenza Other Respir Viruses", "issn": "1750-2659", "issn-l": null}, "abstract": null, "doi": "10.1111/irv.13019", "pmid": "35666005", "labels": {"Category: Omicron VoC": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-20T19:34:35.273Z", "modified": "2022-06-20T19:34:35.310Z"}, {"entity": "publication", "iuid": "97e8169c1e9d46fc836abc9d4315fbd7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/97e8169c1e9d46fc836abc9d4315fbd7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/97e8169c1e9d46fc836abc9d4315fbd7"}}, "title": "Organizational logics in time of crises: How physicians narrate the healthcare response to the Covid-19 pandemic in Swedish hospitals.", "authors": [{"family": "Jacobsson", "given": "Maritha", "initials": "M"}, {"family": "H\u00e4rgestam", "given": "Maria", "initials": "M"}, {"family": "B\u00e5\u00e5the", "given": "Fredrik", "initials": "F"}, {"family": "Hagqvist", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2022-06-03", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "volume": "22", "issue": "1", "pages": "738", "issn-l": null}, "abstract": "The COVID-19 pandemic has challenged healthcare organizations and puts focus on risk management in many ways. Both medical staff and leaders at various levels have been forced to find solutions to problems they had not previously encountered. This study aimed to explore how physicians in Sweden narrated the changes in organizational logic in response to the Covid-19 pandemic using neo-institutional theory and discursive psychology. In specific, we aimed to explore how physicians articulated their understanding of if and, in that case, how the organizational logic has changed during this crisis response.\n\nThe empirical material stems from interviews with 29 physicians in Sweden in the summer and autumn of 2020. They were asked to reflect on the organizational response to the pandemic focusing on leadership, support, working conditions, and patient care.\n\nThe analysis revealed that the organizational logic in Swedish healthcare changed and that the physicians came in troubled positions as leaders. With management, workload, and risk repertoires, the physicians expressed that the organizational logic, to a large extent, was changed based on local contextual circumstances in the 21 self-governing regions. The organizational logic was being altered based upon how the two powerbases (physicians and managers) were interacting over time.\n\nGiven that healthcare probably will deal with future unforeseen crises, it seems essential that healthcare leaders discuss what can be a sustainable organizational logic. There should be more explicit regulatory elements about who is responsible for what in similar situations. The normative elements have probably been stretched during the ongoing crisis, given that physicians have gained practical experience and that there is now also, at least some evidence-based knowledge about this particular pandemic. But the question is what knowledge they need in their education when it comes to dealing with new unknown risks.", "doi": "10.1186/s12913-022-08094-z", "pmid": "35659289", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-022-08094-z"}], "notes": [], "created": "2022-06-21T17:18:03.286Z", "modified": "2022-06-21T17:18:03.302Z"}, {"entity": "publication", "iuid": "cffb2f3684df41d4a4afe77d5311fc77", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cffb2f3684df41d4a4afe77d5311fc77.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cffb2f3684df41d4a4afe77d5311fc77"}}, "title": "Epidemic risk perceptions in Italy and Sweden driven by authority responses to COVID-19.", "authors": [{"family": "Raffetti", "given": "Elena", "initials": "E"}, {"family": "Mondino", "given": "Elena", "initials": "E"}, {"family": "Di Baldassarre", "given": "Giuliano", "initials": "G"}], "type": "journal article", "published": "2022-06-03", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "9291", "issn-l": "2045-2322"}, "abstract": "Understanding public risk perception is an essential step to develop effective measures reducing the spread of disease outbreaks. Here we compare epidemic risk perceptions during two different periods of the COVID-19 pandemic in Italy and Sweden. To this end, we analyzed the results of two nationwide surveys carried out in both countries in two periods characterized by different infection rates: August (N = 4154) and November 2020 (N = 4168). Seven domains of epidemic risk perception were considered: likelihood along with (individual and population) impact, preparedness, and knowledge. The role of the context and period was explored in stratified and formal interaction analyses. In both countries, we found an intensification in epidemic risk perception from August to November 2020. Being male, older and having a higher relative income were associated with a lower perception of the likelihood of epidemics, while excess mortality was marginally related to higher odds. Compared to Sweden, Italy had a higher increase in perception of likelihood and impact, and a concurrent decrease in preparedness and knowledge. The different authority response to the COVID-19 pandemic is associated with a different change over time in risk perception. Regional differences in terms of excess mortality only marginally explained differences in risk perception.", "doi": "10.1038/s41598-022-13218-w", "pmid": "35662262", "labels": {"Type: Journal article": null, "Category: Health": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC9164564"}, {"db": "pii", "key": "10.1038/s41598-022-13218-w"}], "notes": [], "created": "2022-06-20T19:35:33.529Z", "modified": "2023-01-13T14:43:02.040Z"}, {"entity": "publication", "iuid": "0dd07c255c91411ca3447617601e604c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0dd07c255c91411ca3447617601e604c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0dd07c255c91411ca3447617601e604c"}}, "title": "Burden of Disease of COVID-19: Strengthening the Collaboration for National Studies.", "authors": [{"family": "Pires", "given": "Sara Monteiro", "initials": "SM"}, {"family": "Wyper", "given": "Grant M A", "initials": "GMA"}, {"family": "Wengler", "given": "Annelene", "initials": "A"}, {"family": "Pe\u00f1alvo", "given": "Jos\u00e9 L", "initials": "JL"}, {"family": "Haneef", "given": "Romana", "initials": "R"}, {"family": "Moran", "given": "Declan", "initials": "D"}, {"family": "Cuschieri", "given": "Sarah", "initials": "S"}, {"family": "Redondo", "given": "Hernan G", "initials": "HG"}, {"family": "De Pauw", "given": "Robby", "initials": "R"}, {"family": "McDonald", "given": "Scott A", "initials": "SA"}, {"family": "Moon", "given": "Lynelle", "initials": "L"}, {"family": "Shedrawy", "given": "Jad", "initials": "J"}, {"family": "Pallari", "given": "Elena", "initials": "E"}, {"family": "Charalampous", "given": "Periklis", "initials": "P"}, {"family": "Devleesschauwer", "given": "Brecht", "initials": "B"}, {"family": "Von Der Lippe", "given": "Elena", "initials": "E"}], "type": "journal article", "published": "2022-06-03", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "10", "pages": "907012", "issn-l": "2296-2565"}, "abstract": "Quantifying the combined impact of morbidity and mortality is a key enabler to assessing the impact of COVID-19 across countries and within countries relative to other diseases, regions, or demographics. Differences in methods, data sources, and definitions of mortality due to COVID-19 may hamper comparisons. We describe efforts to support countries in estimating the national-level burden of COVID-19 using disability-adjusted life years.\n\nThe European Burden of Disease Network developed a consensus methodology, as well as a range of capacity-building activities to support burden of COVID-19 studies. These activities have supported 11 national studies so far, with study periods between January 2020 and December 2021.\n\nNational studies dealt with various data gaps and different assumptions were made to face knowledge gaps. Still, they delivered broadly comparable results that allow for interpretation of consistencies, as well as differences in the quantified direct health impact of the pandemic.\n\nHarmonized efforts and methodologies have allowed for comparable estimates and communication of results. Future studies should evaluate the impact of interventions, and unravel the indirect health impact of the COVID-19 crisis.", "doi": "10.3389/fpubh.2022.907012", "pmid": "35734754", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC9208200"}], "notes": [], "created": "2022-08-19T05:52:02.531Z", "modified": "2022-08-19T05:52:02.544Z"}, {"entity": "publication", "iuid": "6b3231f157f94108849d7d57fd82e8a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b3231f157f94108849d7d57fd82e8a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b3231f157f94108849d7d57fd82e8a4"}}, "title": "The Karolinska KI/K COVID-19 Immune Atlas: An open resource for immunological research and educational purposes.", "authors": [{"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Ask", "given": "Eivind Heggernes", "initials": "EH", "orcid": "0000-0001-8655-1433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad160fa96dd94738a713f5c6934e61fa.json"}}, {"family": "Cornillet", "given": "Martin", "initials": "M"}, {"family": "Strunz", "given": "Benedikt", "initials": "B"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Rao Muvva", "given": "Jagadeeswara", "initials": "J"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Chambers", "given": "Benedict J", "initials": "BJ", "orcid": "0000-0003-0437-8441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6089d99ec42d475f8f57c8d8cc1ff1de.json"}}, {"family": "Cuapio", "given": "Angelica", "initials": "A", "orcid": "0000-0002-9451-1914", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f4915fdfa7d460f9b705b56b0fc1c4a.json"}}, {"family": "Dzidic", "given": "Majda", "initials": "M"}, {"family": "Filipovic", "given": "Iva", "initials": "I", "orcid": "0000-0002-8166-5500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c79974df90ae4fbf8be348b9b47d0317.json"}}, {"family": "Flodstr\u00f6m-Tullberg", "given": "Malin", "initials": "M"}, {"family": "Garcia", "given": "Marina", "initials": "M"}, {"family": "Gorin", "given": "Jean-Baptiste", "initials": "J"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Hertwig", "given": "Laura", "initials": "L"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Kokkinou", "given": "Efthymia", "initials": "E"}, {"family": "Kvedaraite", "given": "Egle", "initials": "E"}, {"family": "Lourda", "given": "Magda", "initials": "M"}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J"}, {"family": "Maucourant", "given": "Christopher", "initials": "C"}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A"}, {"family": "Palma Medina", "given": "Laura M", "initials": "LM"}, {"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Perez-Potti", "given": "Andr\u00e9", "initials": "A"}, {"family": "Ponzetta", "given": "Andrea", "initials": "A"}, {"family": "Ringqvist", "given": "Emma", "initials": "E"}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Sandberg", "given": "J Tyler", "initials": "JT"}, {"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "Svensson", "given": "Mattias", "initials": "M", "orcid": "0000-0003-1695-7934", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7ae76a597164d02b4fcfadfe53c48a3.json"}}, {"family": "Varnaite", "given": "Renata", "initials": "R"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Karolinska KI/K COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Malmberg", "given": "Karl-Johan", "initials": "K"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}], "type": "journal article", "published": "2022-06-02", "journal": {"title": "Scand J Immunol", "issn": "1365-3083", "issn-l": null, "volume": null, "issue": null, "pages": "e13195"}, "abstract": "The Karolinska KI/K COVID-19 Immune Atlas project was conceptualized in March 2020 as a part of the academic research response to the developing SARS-CoV-2 pandemic. The aim was to rapidly provide a curated dataset covering the acute immune response towards SARS-CoV-2 infection in humans, as it occurred during the first wave. The Immune Atlas was built as an open resource for broad research and educational purposes. It contains a presentation of the response evoked by different immune and inflammatory cells in defined na\u00efve patient-groups as they presented with moderate and severe COVID-19 disease. The present Resource Article describes how the Karolinska KI/K COVID-19 Immune Atlas allow scientists, students, and other interested parties to freely explore the nature of the immune response towards human SARS-CoV-2 infection in an online setting.", "doi": "10.1111/sji.13195", "pmid": "35652743", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Category: Other": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "URL", "key": "http://www.covid19cellatlas.com/", "description": "http://www.covid19cellatlas.com/"}], "notes": [], "created": "2022-06-21T17:25:20.401Z", "modified": "2022-06-21T17:31:07.574Z"}, {"entity": "publication", "iuid": "b0c9b466e4b145bb9cc631e82cf6011c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b0c9b466e4b145bb9cc631e82cf6011c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b0c9b466e4b145bb9cc631e82cf6011c"}}, "title": "The International Academy of Health Sciences Informatics: 2021 Update.", "authors": [{"family": "Hersh", "given": "William R", "initials": "WR"}, {"family": "Haux", "given": "Reinhold", "initials": "R"}, {"family": "Huesing", "given": "Elaine", "initials": "E"}, {"family": "Ball", "given": "Marion J", "initials": "MJ"}, {"family": "Kimura", "given": "Michio", "initials": "M"}, {"family": "Otero", "given": "Paula", "initials": "P"}, {"family": "Detmer", "given": "Don", "initials": "D"}, {"family": "Koch", "given": "Sabine", "initials": "S"}, {"family": "Saranto", "given": "Kaija K", "initials": "KK"}, {"family": "Wright", "given": "Graham", "initials": "G"}], "type": "journal article", "published": "2022-06-02", "journal": {"title": "Yearb Med Inform", "issn": "2364-0502", "issn-l": null}, "abstract": "To summarize the activities of the International Academy of Health Sciences Informatics (IAHSI) in 2021 and welcome its 2021 Class of Fellows.\n\nReport on governance, strategic directions, newly elected fellows, plenary meetings, and other activities of the Academy.\n\nAs in 2020, all of the Academy's activities were carried out virtually due to the COVID-19 pandemic. In 2021, new Board members were elected. Strategic activities in data standards and interoperability and in mentorship moved forward. A new class of 26 Fellows was elected, bringing the total membership of the Academy to 204 Fellows from all regions of the world. In addition, a virtual plenary meeting was held.\n\nThe Academy has continued to pursue its role as the honorific society globally for biomedical and health informatics. Expansion of strategic activities and membership will continue moving forward.", "doi": "10.1055/s-0042-1742501", "pmid": "35654427", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T17:20:41.316Z", "modified": "2022-06-21T17:20:41.329Z"}, {"entity": "publication", "iuid": "b8b02774a6a744df875d0f9e1a91c944", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8b02774a6a744df875d0f9e1a91c944.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8b02774a6a744df875d0f9e1a91c944"}}, "title": "No learning loss in Sweden during the pandemic evidence from primary school reading assessments.", "authors": [{"family": "Hallin", "given": "Anna Eva", "initials": "AE"}, {"family": "Danielsson", "given": "Henrik", "initials": "H"}, {"family": "Nordstr\u00f6m", "given": "Thomas", "initials": "T"}, {"family": "F\u00e4lth", "given": "Linda", "initials": "L"}], "type": "journal article", "published": "2022-06-02", "journal": {"title": "Int J Educ Res", "issn": "0883-0355", "issn-l": null, "volume": "114", "issue": null, "pages": "102011"}, "abstract": "The COVID-19 pandemic has led to worldwide school closures, with a risk of learning loss. Sweden kept primary schools open, but it is unknown whether student and teacher absence and pandemic-related stress factors affected teaching and student progress negatively. In this study, reading assessment data from 97,073 Swedish primary school students (grades 1-3) were analysed to investigate potential learning loss. Results showed that word decoding and reading comprehension scores were not lower during the pandemic compared to before the pandemic, that students from low socio-economic backgrounds were not especially affected, and that the proportion of students with weak decoding skills did not increase during the pandemic. Study limitations are discussed. We conclude that open schools benefitted Swedish primary school students.", "doi": "10.1016/j.ijer.2022.102011", "pmid": "35677729", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0883-0355(22)00089-1"}, {"db": "pmc", "key": "PMC9162440"}], "notes": [], "created": "2022-06-20T19:31:04.068Z", "modified": "2022-11-09T08:42:18.260Z"}, {"entity": "publication", "iuid": "8ecf67a8c27045238eed362c6919a052", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ecf67a8c27045238eed362c6919a052.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ecf67a8c27045238eed362c6919a052"}}, "title": "Integration of systematic screening for tuberculosis in outpatient departments of urban primary healthcare facilities in Zambia: a case study of Kitwe district.", "authors": [{"family": "Zulu", "given": "Davy Wadula", "initials": "DW"}, {"family": "Silumbwe", "given": "Adam", "initials": "A"}, {"family": "Maritim", "given": "Patricia", "initials": "P"}, {"family": "Zulu", "given": "Joseph Mumba", "initials": "JM"}], "type": "journal article", "published": "2022-06-02", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "volume": "22", "issue": "1", "pages": "732", "issn-l": null}, "abstract": "Tuberculosis (TB) is the leading cause of death from a single infectious agent globally, killing about 1.5 million people annually, yet 3 million cases are missed every year. The World Health Organization recommends systematic screening of suspected active TB patients among those visiting the healthcare facilities. While many countries have scaled-up systematic screening of TB, there has been limited assessment of the extent of its integration into the health system. This study sought to explore factors that shape the integration of systematic screening of TB in outpatient departments of primary healthcare facilities in Kitwe district, Zambia.\n\nThis was a qualitative case study with health providers including district managers, TB focal point persons and laboratory personnel working in six purposively selected primary healthcare facilities. Data was collected through key informant (n = 8) and in-depth (n = 15) interviews. Data analysis was conducted using QDA Miner software and guided by Atun's Integration framework.\n\nThe facilitators to integration of systematic screening for TB into out patient departments of primary health facilities included the perceived high burden TB, compatibility of the systematic screening for TB program with healthcare workers training and working schedules, stakeholder knowledge of each others interest and values, regular performance management and integrated outreach of TB screening services. Constraining factors to integration of systematic screening for TB into outpatient departments included complexity of screening for TB in children, unbalanced incentivization mechanisms, ownership and legitimacy of the TB screening program, negative health worker attitudes, social cultural misconceptions of TB and societal stigma as well as the COVID-19 pandemic.\n\nSystematic screening of TB is not fully integrated into the primary healthcare facilities in Zambia to capture all those suspected with active TB that make contact with the health system. Finding the missing TB cases will, therefore, require contextual adaptation of the systematic screening for TB program to local needs and capacities as well as strengthening the health system.", "doi": "10.1186/s12913-022-08043-w", "pmid": "35655301", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-022-08043-w"}], "notes": [], "created": "2022-06-21T17:20:22.124Z", "modified": "2022-06-21T17:20:22.136Z"}, {"entity": "publication", "iuid": "6cca6c1a8846428ba8ad2030031ab08e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6cca6c1a8846428ba8ad2030031ab08e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6cca6c1a8846428ba8ad2030031ab08e"}}, "title": "Changes in Brain-Health Related Modifiable Risk Factors in Older Adults After One Year of COVID-19-Restrictions.", "authors": [{"family": "Waterink", "given": "Lisa", "initials": "L"}, {"family": "Bakker", "given": "Els D", "initials": "ED"}, {"family": "Visser", "given": "Leonie N C", "initials": "LNC"}, {"family": "Mangialasche", "given": "Francesca", "initials": "F"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Deckers", "given": "Kay", "initials": "K"}, {"family": "K\u00f6hler", "given": "Sebastian", "initials": "S"}, {"family": "Sikkes", "given": "Sietske A M", "initials": "SAM"}, {"family": "Prins", "given": "Niels D", "initials": "ND"}, {"family": "Scheltens", "given": "Philip", "initials": "P"}, {"family": "van der Flier", "given": "Wiesje M", "initials": "WM"}, {"family": "Zwan", "given": "Marissa D", "initials": "MD"}], "type": "journal article", "published": "2022-06-02", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "13", "pages": "877460", "issn-l": "1664-0640"}, "abstract": "The COVID-19 pandemic has major influence on lifestyle and mental health, which might affect brain-health and increase the risk of cognitive decline, particularly in older adults. We aimed to describe changes in modifiable risk factors related to brain-health in older adults after one year of COVID-19 restrictions.\n\nAn online survey was disseminated between February and March 2021 to 17,773 registrants of the Dutch Brain Research Registry, aged \u226550, without a self-reported diagnosis of mild cognitive impairment or dementia. Participants were asked to report potential changes in behaviors during the COVID-19 pandemic, compared to pre-pandemic, in eight domains related to brain health: physical activity, sleep, feeling of memory decline, perceived stress, feeling of loneliness, diet, alcohol consumption, and smoking. We used negative binomial regression analyses to relate (socio)demographics, subjective memory complaints and COVID-19 related aspects (fear of, or current/past COVID-19 infection) to the number of reported detrimental and beneficial changes as dependent variable.\n\n3,943 participants (66 \u00b1 8 years old; 76% female; 71% highly educated) completed the survey. After one year of COVID-19-restrictions, 74% reported at least one detrimental lifestyle change unfavorable for their brain health, most frequently reported were feelings of loneliness, sleep problems, and less physical activity. 60% of participants reported at least one beneficial change, which were most often more physical activity, healthier dietary habits, and less alcohol consumption. Individuals who are younger [incidence rate ratio (IRR) = 0.99, 95% CI = 0.98-0.99], female (1.20, 1.11-1.30), living alone (1.20, 1.11-1.28) and in urban environments (1.18, 1.08-1.29), who are less satisfied with their income (1.38, 1.17-1.62), experiencing subjective memory complaints (1.40, 1.28-1.52) and those with a past or current (1.19, 1.06-1.34) or fear of a COVID-19 infection (1.33, 1.25-1.42) reported higher numbers of detrimental changes.\n\nThe COVID-19 pandemic has influenced lifestyle in both positive and negative ways. We identified (socio)demographic factors associated with more detrimental changes in modifiable risk factors related to brain health, suggesting that some individuals are more vulnerable for the impact of the COVID-19 pandemic. These findings provide an opportunity for targeted prevention and education to promote a healthy lifestyle during and after the pandemic.", "doi": "10.3389/fpsyt.2022.877460", "pmid": "35722572", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9201112"}], "notes": [], "created": "2022-06-20T18:04:12.788Z", "modified": "2022-08-17T12:45:33.702Z"}, {"entity": "publication", "iuid": "9cd5cf69381f4d3196ee195a00a48d84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9cd5cf69381f4d3196ee195a00a48d84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9cd5cf69381f4d3196ee195a00a48d84"}}, "title": "A Network Analysis of the Fear of COVID-19 Scale (FCV-19S): A Large-Scale Cross-Cultural Study in Iran, Bangladesh, and Norway.", "authors": [{"family": "Lecuona", "given": "Oscar", "initials": "O", "orcid": "0000-0003-0080-1062", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3c84f17b7bf4210aa39eeb252d8bd33.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Rozgonjuk", "given": "Dmitri", "initials": "D"}, {"family": "Norekv\u00e5l", "given": "Tone M", "initials": "TM"}, {"family": "Iversen", "given": "Marjolein M", "initials": "MM"}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA", "orcid": "0000-0002-1728-8966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6e65a5a97154d159a63cc2ce3f1b7a8.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Lin", "given": "Ting-I", "initials": "TI"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2022-06-02", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "11", "issn-l": null}, "abstract": "The rapid spread of the coronavirus disease 2019 (COVID-19) has led to high levels of fear worldwide. Given that fear is an important factor in causing psychological distress and facilitating preventive behaviors, assessing the fear of COVID-19 is important. The seven-item Fear of COVID-19 Scale (FCV-19S) is a widely used psychometric instrument to assess this fear. However, the factor structure of the FCV-19S remains unclear according to the current evidence. Therefore, the present study used a network analysis to provide further empirical evidence for the factor structure of FCV-19S. A total of 24,429 participants from Iran (n = 10,843), Bangladesh (n = 9906), and Norway (n = 3680) completed the FCV-19S in their local language. A network analysis (via regularized partial correlation networks) was applied to investigate the seven FCV-19S items. Moreover, relationships between the FCV-19S items were compared across gender (males vs. females), age groups (18-30 years, 31-50 years, and &gt;50 years), and countries (Iran, Bangladesh, and Norway). A two-factor structure pattern was observed (three items concerning physical factors, including clammy hands, insomnia, and heart palpitations; four items concerning psychosocial factors, including being afraid, uncomfortable, afraid of dying, and anxious about COVID-19 news). Moreover, this pattern was found to be the same among men and women, across age groups and countries. The network analysis used in the present study verified the two-factor structure for the FCV-19S. Future studies may consider using the two-factor structure of FCV-19S to assess the fear of COVID-19 during the COVID-19 era.", "doi": "10.3390/ijerph19116824", "pmid": "35682405", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19116824"}], "notes": [], "created": "2022-06-20T19:27:26.888Z", "modified": "2022-06-20T19:27:26.996Z"}, {"entity": "publication", "iuid": "f479e90cff3441c792c233351414db88", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f479e90cff3441c792c233351414db88.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f479e90cff3441c792c233351414db88"}}, "title": "Remote investigation and assessment of vital signs (RIA-VS)-proof of concept for contactless estimation of blood pressure, pulse, respiratory rate, and oxygen saturation in patients with suspicion of COVID-19.", "authors": [{"family": "Malmberg", "given": "Stefan", "initials": "S"}, {"family": "Khan", "given": "Taha", "initials": "T"}, {"family": "Gunnarsson", "given": "Ronny", "initials": "R", "orcid": "0000-0001-9183-3072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f25154a31c304d23bb9d37ec121eedd2.json"}}, {"family": "Jacobsson", "given": "Gunnar", "initials": "G"}, {"family": "Sundvall", "given": "P\u00e4r-Daniel", "initials": "PD"}], "type": "journal article", "published": "2022-06-01", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "pages": "1-10", "issn-l": "2374-4235"}, "abstract": "Vital signs are critical in assessing the severity and prognosis of infections, for example, COVID-19, influenza, sepsis, and pneumonia. This study aimed to evaluate a new method for rapid camera-based non-contact measurement of heart rate, blood oxygen saturation, respiratory rate, and blood pressure.\n\nConsecutive adult patients attending a hospital emergency department for suspected COVID-19 infection were invited to participate. Vital signs measured with a new camera-based method were compared to the corresponding standard reference methods. The camera device observed the patient's face for 30 s from \u223c1 m.\n\nBetween 1 April and 1 October 2020, 214 subjects were included in the trial, 131 female (61%) and 83 male (39%). The mean age was 44 years (range 18-81 years). The new camera-based device's vital signs measurements were, on average, very close to the gold standard but the random variation was larger than the reference methods.\n\nThe principle of contactless measurement of blood pressure, pulse, respiratory rate, and oxygen saturation works, which is very promising. However, technical improvements to the equipment used in this study to reduce its random variability is required before clinical implementation. This will likely be a game changer once this is sorted out.\n\nUniversal Trial Number (UTN) U1111-1251-4114 and the ClinicalTrials.gov Identifier NCT04383457.", "doi": "10.1080/23744235.2022.2080249", "pmid": "35651319", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT04383457"}], "notes": [], "created": "2022-06-21T17:31:18.532Z", "modified": "2022-06-21T17:31:18.615Z"}, {"entity": "publication", "iuid": "b69f6910420f46ae80cc4a4072f8d2c4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b69f6910420f46ae80cc4a4072f8d2c4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b69f6910420f46ae80cc4a4072f8d2c4"}}, "title": "Missed nursing care in the critical care unit, before and during the COVID-19 pandemic: A comparative cross-sectional study.", "authors": [{"family": "Falk", "given": "Ann-Charlotte", "initials": "AC"}, {"family": "Nymark", "given": "Carolin", "initials": "C"}, {"family": "G\u00f6ransson", "given": "Katarina E", "initials": "KE"}, {"family": "von Vogelsang", "given": "Ann-Christin", "initials": "AC"}], "type": "journal article", "published": "2022-06-01", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "pages": "103276", "issn-l": null}, "abstract": "Todescribe and evaluate reported missed nursing care in the critical care context during different phases of the COVID-19 pandemic in Sweden.\n\nA comparative cross-sectional design was used, comparing missed nursing care in three samples: before the COVID-19 pandemic in 2019, during the second wave of the pandemic in spring 2020, and during the third wave of the pandemic in fall 2021.\n\nThe study was conducted at critical care units at a university hospital, Sweden.\n\nThe MISSCARE Survey-Swedish version was used to collect data along with two study-specific questions concerning perception of patient safety and quality of care.\n\nSignificantly more overtime hours and number of days absent due to illness were reported during the pandemic. The nurse/patient ratio was above the recommended level at all data collection time points. Most missed nursing care was reported in items concerning basic care. The most reported reasons for missed nursing care in all samples concerned inadequate staffing, urgent situations, and a rise in patient volume. Most nurses in all samples perceived the level of patient safety and quality of care as good, and the majority had no intention to leave their current position.\n\nThe pandemic had a great impact on the critical care workforce but few elements of missed nursing care were affected. To measure and use missed nursing care as a quality indicator could be valuable for nursing managers, to inform them and improve their ability to meet changes in patient needs with different workforce approaches in critical care settings.", "doi": "10.1016/j.iccn.2022.103276", "pmid": "35672210", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(22)00079-9"}], "notes": [], "created": "2022-06-20T19:31:47.138Z", "modified": "2022-06-20T19:31:56.430Z"}, {"entity": "publication", "iuid": "d6bb41724d964351a7463e2ac105f5f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d6bb41724d964351a7463e2ac105f5f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d6bb41724d964351a7463e2ac105f5f7"}}, "title": "Discovery of a Novel Coronavirus in Swedish Bank Voles (Myodes glareolus).", "authors": [{"family": "Wasberg", "given": "Anishia", "initials": "A"}, {"family": "Raghwani", "given": "Jayna", "initials": "J"}, {"family": "Li", "given": "Jinlin", "initials": "J"}, {"family": "Pettersson", "given": "John H-O", "initials": "JH"}, {"family": "Lindahl", "given": "Johanna F", "initials": "JF"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}], "type": "journal article", "published": "2022-06-01", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "6", "issn-l": "1999-4915"}, "abstract": "The unprecedented pandemic COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with bats as original reservoirs, has once again highlighted the importance of exploring the interface of wildlife diseases and human health. In this study, we identified a novel Betacoronavirus from bank voles (Myodes glareolus) in Grims\u00f6, Sweden, and this virus is designated as Grimso virus. Repeated detection over three years and an overall prevalence of 3.4% suggest that the virus commonly occurs in bank voles. Furthermore, phylogenetic analyses indicate that the Grimso virus belongs to a highly divergent Embecovirus lineage predominantly associated with bank voles. Given that bank voles are one of the most common rodent species in Sweden and Europe, our findings indicate that Grimso virus might be circulating widely in bank voles and further point out the importance of sentinel surveillance of coronaviruses in wild small mammalian animals, especially in wild rodents.", "doi": "10.3390/v14061205", "pmid": "35746677", "labels": {"Category: Biochemistry": null, "Research Area: Pandemic preparedness": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "v14061205"}, {"db": "pmc", "key": "PMC9230040"}], "notes": [], "created": "2022-08-19T05:41:46.521Z", "modified": "2022-08-19T05:43:22.484Z"}, {"entity": "publication", "iuid": "0ff90e6d55554880898f48eeadecda4f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ff90e6d55554880898f48eeadecda4f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ff90e6d55554880898f48eeadecda4f"}}, "title": "COVID-19 vaccines coverage and effectiveness against SARS-CoV-2 infection among residents in the largest Health Authority of Lazio region (Italy): a population-based cohort study.", "authors": [{"family": "Fano", "given": "Valeria", "initials": "V", "orcid": "0000-0003-1396-4928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39fbb5a6eee549c9b1cc336f36e8715c.json"}}, {"family": "Coviello", "given": "Enzo", "initials": "E", "orcid": "0000-0002-8396-2306", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c990efa224a4fc58ef9c318cbfe9541.json"}}, {"family": "Consonni", "given": "Dario", "initials": "D", "orcid": "0000-0002-8935-3843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f533ba417cb4950b77f0b4be5ad8f97.json"}}, {"family": "Agresta", "given": "Alessandro", "initials": "A", "orcid": "0000-0001-8890-0342", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/516cab6c029742b4a037b0f3478df969.json"}}, {"family": "Orsini", "given": "Nicola", "initials": "N", "orcid": "0000-0002-2210-5634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6161818f1f74a26883d3b1e37e72f2e.json"}}, {"family": "Crielesi", "given": "Alessia", "initials": "A"}, {"family": "Miglietta", "given": "Antonio Salvatore", "initials": "AS"}, {"family": "Pasqua", "given": "Caterina", "initials": "C"}, {"family": "Vairo", "given": "Francesco", "initials": "F", "orcid": "0000-0002-8375-7468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d99df4cf90cf43df92915c18d8b97e06.json"}}, {"family": "Vivaldi", "given": "Fabio", "initials": "F"}, {"family": "De Angelis", "given": "Giuseppe", "initials": "G"}, {"family": "Colaiocco", "given": "Giovanni", "initials": "G"}, {"family": "Fabiani", "given": "Massimo", "initials": "M", "orcid": "0000-0002-5893-7117", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6edd0048b0204f43972a2cb3dc08518d.json"}}], "type": "journal article", "published": "2022-06-01", "journal": {"title": "Expert Rev Vaccines", "issn": "1744-8395", "pages": "1-11", "issn-l": null}, "abstract": "The waning of the protective effect of COVID-19 vaccines and timing of booster doses are debated.\n\nPopulation-based cohort study in the largest Health-Authority of Lazio region, Italy, on 946,156 residents aged 12+ (study period: 1 January 2021-10 January 2022). Vaccine effectiveness (VE) against any SARS-CoV-2 infection (symptomatic or asymptomatic) was estimated through multivariable negative-binomial models using unvaccinated person-time as a reference.\n\nThe primary vaccination cycle was completed by 81% of residents; of these, 45% received a booster dose. Vaccine coverages were lower for foreigners, and people living in deprived areas, families with children aged 0-11, and households size 1 or 6+. Overall, VE waned from 71% (95% Confidence Interval (CI) 70-73%) 1 month after the second dose to 43% (CI 41-45%) after 4 months and 24% (CI 21-27%) after 6 months, especially in the elderly aged 70+. We observed a prompt restore of VE 15-19 days after the booster dose (69%, CI 67-70%).\n\nOur results support the recommendation of a booster dose 4 months after completion of the primary cycle, giving priority to elderly and fragile individuals. The lower vaccine coverage among social disadvantaged subgroups suggests the need of targeted communication and interventions.", "doi": "10.1080/14760584.2022.2080057", "pmid": "35584901", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T18:02:42.371Z", "modified": "2022-06-21T18:02:58.354Z"}, {"entity": "publication", "iuid": "28ed47e1513143fea34a4e0061bcd804", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/28ed47e1513143fea34a4e0061bcd804.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/28ed47e1513143fea34a4e0061bcd804"}}, "title": "Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double-blind, randomised, controlled, phase 3 trial.", "authors": [{"family": "Upton", "given": "Caryn M", "initials": "CM"}, {"family": "van Wijk", "given": "Rob C", "initials": "RC"}, {"family": "Mockeliunas", "given": "Laurynas", "initials": "L"}, {"family": "Simonsson", "given": "Ulrika S H", "initials": "USH"}, {"family": "McHarry", "given": "Kirsten", "initials": "K"}, {"family": "van den Hoogen", "given": "Gerben", "initials": "G"}, {"family": "Muller", "given": "Chantal", "initials": "C"}, {"family": "von Delft", "given": "Arn\u00e9", "initials": "A"}, {"family": "van der Westhuizen", "given": "Helene-Mari", "initials": "HM"}, {"family": "van Crevel", "given": "Reinout", "initials": "R"}, {"family": "Walzl", "given": "Gerhard", "initials": "G"}, {"family": "Baptista", "given": "Pedro M", "initials": "PM"}, {"family": "Peter", "given": "Jonathan", "initials": "J"}, {"family": "Diacon", "given": "Andreas H", "initials": "AH"}, {"family": "BCG CORONA Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": "48", "pages": "101414", "issn-l": null}, "abstract": "BCG vaccination prevents severe childhood tuberculosis (TB) and was introduced in South Africa in the 1950s. It is hypothesised that BCG trains the innate immune system by inducing epigenetic and functional reprogramming, thus providing non-specific protection from respiratory tract infections. We evaluated BCG for reduction of morbidity and mortality due to COVID-19 in healthcare workers in South Africa.\n\nThis randomised, double-blind, placebo-controlled trial recruited healthcare workers at three facilities in the Western Cape, South Africa, unless unwell, pregnant, breastfeeding, immunocompromised, hypersensitivity to BCG, or undergoing experimental COVID-19 treatment. Participants received BCG or saline intradermally (1:1) and were contacted once every 4 weeks for 1 year. COVID-19 testing was guided by symptoms. Hospitalisation, COVID-19, and respiratory tract infections were assessed with Cox proportional hazard modelling and time-to-event analyses, and event severity with post hoc Markovian analysis. This study is registered with ClinicalTrials.gov, NCT04379336.\n\nBetween May 4 and Oct 23, 2020, we enrolled 1000 healthcare workers with a median age of 39 years (IQR 30-49), 70\u00b74% were female, 16\u00b75% nurses, 14\u00b74% medical doctors, 48\u00b75% had latent TB, and 15\u00b73% had evidence of prior SARS-CoV-2 exposure. Hospitalisation due to COVID-19 occurred in 15 participants (1\u00b75%); ten (66\u00b77%) in the BCG group and five (33\u00b73%) in the placebo group, hazard ratio (HR) 2\u00b70 (95% CI 0\u00b769-5\u00b79, p = 0\u00b720), indicating no statistically significant protection. Similarly, BCG had no statistically significant effect on COVID-19 (p = 0\u00b763, HR = 1\u00b708, 95% CI 0\u00b782-1\u00b742). Two participants (0\u00b72%) died from COVID-19 and two (0\u00b72%) from other reasons, all in the placebo group.\n\nBCG did not protect healthcare workers from SARS-CoV-2 infection or related severe COVID-19 disease and hospitalisation.\n\nFunding provided by EDCTP, grant number RIA2020EF-2968. Additional funding provided by private donors including: Mediclinic, Calavera Capital (Pty) Ltd, Thys Du Toit, Louis Stassen, The Ryan Foundation, and Dream World Investments 401 (Pty) Ltd. The computations were enabled by resources in project SNIC 2020-5-524 provided by the Swedish National Infrastructure for Computing (SNIC) at UPPMAX, partially funded by the Swedish Research Council through grant agreement No. 2018-05,973.", "doi": "10.1016/j.eclinm.2022.101414", "pmid": "35582122", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(22)00144-4"}, {"db": "pmc", "key": "PMC9098089"}, {"db": "ClinicalTrials.gov", "key": "NCT04379336"}], "notes": [], "created": "2022-06-21T18:04:16.071Z", "modified": "2022-06-21T18:04:16.083Z"}, {"entity": "publication", "iuid": "c5f19680051c403ea6589f082ed762df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5f19680051c403ea6589f082ed762df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5f19680051c403ea6589f082ed762df"}}, "title": "SARS-CoV-2 Omicron variants BA.1 and BA.2 both show similarly reduced disease severity of COVID-19 compared to Delta, Germany, 2021 to 2022.", "authors": [{"family": "Sievers", "given": "Claudia", "initials": "C"}, {"family": "Zacher", "given": "Benedikt", "initials": "B"}, {"family": "Ullrich", "given": "Alexander", "initials": "A"}, {"family": "Huska", "given": "Matthew", "initials": "M"}, {"family": "Fuchs", "given": "Stephan", "initials": "S"}, {"family": "Buda", "given": "Silke", "initials": "S"}, {"family": "Haas", "given": "Walter", "initials": "W"}, {"family": "Diercke", "given": "Michaela", "initials": "M"}, {"family": "An der Heiden", "given": "Matthias", "initials": "M"}, {"family": "Kr\u00f6ger", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "27", "issue": "22", "issn-l": null}, "abstract": "German national surveillance data analysis shows that hospitalisation odds associated with Omicron lineage BA.1 or BA.2 infections are up to 80% lower than with Delta infection, primarily in \u2265 35-year-olds. Hospitalised vaccinated Omicron cases' proportions (2.3% for both lineages) seemed lower than those of the unvaccinated (4.4% for both lineages). Independent of vaccination status, the hospitalisation frequency among cases with Delta seemed nearly threefold higher (8.3%) than with Omicron (3.0% for both lineages), suggesting that Omicron inherently causes less severe disease.", "doi": "10.2807/1560-7917.ES.2022.27.22.2200396", "pmid": "35656831", "labels": {"Category: Omicron VoC": null, "Type: Journal article": null, "Category: Health": null, "Category: Genomics & transcriptomics": null}, "xrefs": [], "notes": [], "created": "2022-06-21T17:18:36.850Z", "modified": "2022-06-21T17:18:55.633Z"}, {"entity": "publication", "iuid": "a33a47868288439ebae157b0221bb4f5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a33a47868288439ebae157b0221bb4f5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a33a47868288439ebae157b0221bb4f5"}}, "title": "Risk of SARS-CoV-2 reinfection and COVID-19 hospitalisation in individuals with natural and hybrid immunity: a retrospective, total population cohort study in Sweden.", "authors": [{"family": "Nordstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Ballin", "given": "Marcel", "initials": "M"}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "volume": "22", "issue": "6", "pages": "781-790", "issn-l": null}, "abstract": "Real-world evidence supporting vaccination against COVID-19 in individuals who have recovered from a previous SARS-CoV-2 infection is sparse. We aimed to investigate the long-term protection from a previous infection (natural immunity) and whether natural immunity plus vaccination (hybrid immunity) was associated with additional protection.\n\nIn this retrospective cohort study, we formed three cohorts using Swedish nationwide registers managed by the Public Health Agency of Sweden, the National Board of Health and Welfare, and Statistics Sweden. Cohort 1 included unvaccinated individuals with natural immunity matched pairwise on birth year and sex to unvaccinated individuals without natural immunity at baseline. Cohort 2 and cohort 3 included individuals vaccinated with one dose (one-dose hybrid immunity) or two doses (two-dose hybrid immunity) of a COVID-19 vaccine, respectively, after a previous infection, matched pairwise on birth year and sex to individuals with natural immunity at baseline. Outcomes of this study were documented SARS-CoV-2 infection from March 20, 2020, until Oct 4, 2021, and inpatient hospitalisation with COVID-19 as main diagnosis from March 30, 2020, until Sept 5, 2021.\n\nCohort 1 was comprised of 2 039 106 individuals, cohort 2 of 962 318 individuals, and cohort 3 of 567 810 individuals. During a mean follow-up of 164 days (SD 100), 34 090 individuals with natural immunity in cohort 1 were registered as having had a SARS-CoV-2 reinfection compared with 99 168 infections in non-immune individuals; the numbers of hospitalisations were 3195 and 1976, respectively. After the first 3 months, natural immunity was associated with a 95% lower risk of SARS-CoV-2 infection (adjusted hazard ratio [aHR] 0\u00b705 [95% CI 0\u00b705-0\u00b705] p<0\u00b7001) and an 87% (0\u00b713 [0\u00b711-0\u00b716]; p<0\u00b7001) lower risk of COVID-19 hospitalisation for up to 20 months of follow-up. During a mean follow-up of 52 days (SD 38) in cohort 2, 639 individuals with one-dose hybrid immunity were registered with a SARS-CoV-2 reinfection, compared with 1662 individuals with natural immunity (numbers of hospitalisations were eight and 113, respectively). One-dose hybrid immunity was associated with a 58% lower risk of SARS-CoV-2 reinfection (aHR 0\u00b742 [95% CI 0\u00b738-0\u00b747]; p<0\u00b7001) than natural immunity up to the first 2 months, with evidence of attenuation thereafter up to 9 months (p<0\u00b7001) of follow-up. During a mean follow-up of 66 days (SD 53) in cohort 3, 438 individuals with two-dose hybrid immunity were registered as having had a SARS-CoV-2 reinfection, compared with 808 individuals with natural immunity (numbers of hospitalisations were six and 40, respectively). Two-dose hybrid immunity was associated with a 66% lower risk of SARS-CoV-2 reinfection (aHR 0\u00b734 [95% CI 0\u00b731-0\u00b739]; p<0\u00b7001) than natural immunity, with no significant attenuation up to 9 months (p=0\u00b707). To prevent one reinfection in the natural immunity cohort during follow-up, 767 individuals needed to be vaccinated with two doses. Both one-dose (HR adjusted for age and baseline date 0\u00b706 [95% CI 0\u00b703-0\u00b712]; p<0\u00b7001) and two-dose (HR adjusted for age and baseline date 0\u00b710 [0\u00b704-0\u00b722]; p<0\u00b7001) hybrid immunity were associated with a lower risk of COVID-19 hospitalisation than natural immunity.\n\nThe risk of SARS-CoV-2 reinfection and COVID-19 hospitalisation in individuals who have survived and recovered from a previous infection remained low for up to 20 months. Vaccination seemed to further decrease the risk of both outcomes for up to 9 months, although the differences in absolute numbers, especially in hospitalisations, were small. These findings suggest that if passports are used for societal restrictions, they should acknowledge either a previous infection or vaccination as proof of immunity, as opposed to vaccination only.\n\nNone.", "doi": "10.1016/S1473-3099(22)00143-8", "pmid": "35366962", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8971363"}, {"db": "pii", "key": "S1473-3099(22)00143-8"}], "notes": [], "created": "2022-04-04T06:21:49.284Z", "modified": "2023-07-13T11:28:04.534Z"}, {"entity": "publication", "iuid": "8151ff7d54534086a1eb2b358c68a32d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8151ff7d54534086a1eb2b358c68a32d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8151ff7d54534086a1eb2b358c68a32d"}}, "title": "Rapidly adapting primary care sentinel surveillance across seven countries in Europe for COVID-19 in the first half of 2020: strengths, challenges, and lessons learned.", "authors": [{"family": "Bagaria", "given": "Jayshree", "initials": "J"}, {"family": "Jansen", "given": "Tessa", "initials": "T"}, {"family": "Marques", "given": "Diogo Fp", "initials": "DF"}, {"family": "Hooiveld", "given": "Mariette", "initials": "M"}, {"family": "McMenamin", "given": "Jim", "initials": "J"}, {"family": "de Lusignan", "given": "Simon", "initials": "S"}, {"family": "Vilcu", "given": "Ana-Maria", "initials": "AM"}, {"family": "Meijer", "given": "Adam", "initials": "A"}, {"family": "Rodrigues", "given": "Ana-Paula", "initials": "AP"}, {"family": "Brytting", "given": "Mia", "initials": "M"}, {"family": "Mazagatos", "given": "Clara", "initials": "C"}, {"family": "Cogdale", "given": "Jade", "initials": "J"}, {"family": "van der Werf", "given": "Sylvie", "initials": "S"}, {"family": "Dijkstra", "given": "Frederika", "initials": "F"}, {"family": "Guiomar", "given": "Raquel", "initials": "R"}, {"family": "Enkirch", "given": "Theresa", "initials": "T"}, {"family": "Valenciano", "given": "Marta", "initials": "M"}, {"family": "I-MOVE-COVID-19 study team", "given": "", "initials": ""}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "27", "issue": "26", "issn-l": null}, "abstract": "As the COVID-19 pandemic began in early 2020, primary care influenza sentinel surveillance networks within the Influenza - Monitoring Vaccine Effectiveness in Europe (I-MOVE) consortium rapidly adapted to COVID-19 surveillance. This study maps system adaptations and lessons learned about aligning influenza and COVID-19 surveillance following ECDC / WHO/Europe recommendations and preparing for other diseases possibly emerging in the future. Using a qualitative approach, we describe the adaptations of seven sentinel sites in five European Union countries and the United Kingdom during the first pandemic phase (March-September 2020). Adaptations to sentinel systems were substantial (2/7 sites), moderate (2/7) or minor (3/7 sites). Most adaptations encompassed patient referral and sample collection pathways, laboratory testing and data collection. Strengths included established networks of primary care providers, highly qualified testing laboratories and stakeholder commitments. One challenge was the decreasing number of samples due to altered patient pathways. Lessons learned included flexibility establishing new routines and new laboratory testing. To enable simultaneous sentinel surveillance of influenza and COVID-19, experiences of the sentinel sites and testing infrastructure should be considered. The contradicting aims of rapid case finding and contact tracing, which are needed for control during a pandemic and regular surveillance, should be carefully balanced.", "doi": "10.2807/1560-7917.ES.2022.27.26.2100864", "pmid": "35775429", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9248262"}], "notes": [], "created": "2022-08-17T13:12:39.666Z", "modified": "2022-08-17T13:12:39.680Z"}, {"entity": "publication", "iuid": "21ddc26f77ed4aa39fe287b3b80f6cc8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/21ddc26f77ed4aa39fe287b3b80f6cc8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/21ddc26f77ed4aa39fe287b3b80f6cc8"}}, "title": "Prevalence of gaming addiction and its impact on sleep quality: A cross-sectional study from Pakistan.", "authors": [{"family": "Zaman", "given": "Musharaf", "initials": "M"}, {"family": "Babar", "given": "Muhammad Saad", "initials": "MS"}, {"family": "Babar", "given": "Maryam", "initials": "M"}, {"family": "Sabir", "given": "Faheem", "initials": "F"}, {"family": "Ashraf", "given": "Farzana", "initials": "F"}, {"family": "Tahir", "given": "Muhammad Junaid", "initials": "MJ"}, {"family": "Ullah", "given": "Irfan", "initials": "I"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Ann Med Surg (Lond)", "issn": "2049-0801", "volume": "78", "pages": "103641", "issn-l": null}, "abstract": "Gaming addiction has become a topic of increasing research interest worldwide but little research has been carried out in Pakistan.\n\nThe present study assessed the prevalence of gaming addiction among a Pakistani sample of adults in the general population. It also explored the effects of online gaming addiction upon sleep quality.\n\nA cross-sectional survey was carried out during a national lockdown due to the COVID-19 pandemic in Pakistan. Using a convenience sampling technique, an online survey comprising demographic information, the Game Addiction Scale (GAS), and the Pittsburgh Sleep Quality Index (PSQI) was completed by 618 participants (67.5% male) aged 18-56 years (M = 24.53 years, SD = \u00b15.016).\n\nOut of 618 participants, 57.0% (n=352) played online games. Among gamers, 12.5% (n = 44) were classed as addicted to the gaming based on GAS scores. Compared to those not addicted to gaming, participants with gaming addiction had significantly poorer subjective sleep quality, higher sleep disturbance, lesser sleep duration, and higher daytime dysfunction. Gaming addiction was also more prevalent among males compared to females.\n\nGaming addiction among the Pakistani general population is significantly associated with poor sleep quality. This problem needs to be addressed at both individual and societal levels to avoid adverse long-term health impacts.", "doi": "10.1016/j.amsu.2022.103641", "pmid": "35734653", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2049-0801(22)00401-0"}, {"db": "pmc", "key": "PMC9206897"}], "notes": [], "created": "2022-08-19T05:52:20.807Z", "modified": "2022-08-19T05:52:20.821Z"}, {"entity": "publication", "iuid": "be40558f2b164b9fa6df518204e5e100", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be40558f2b164b9fa6df518204e5e100.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be40558f2b164b9fa6df518204e5e100"}}, "title": "Nurses' lived experiences of caring for patients with COVID-19: a phenomenological study.", "authors": [{"family": "Heydarikhayat", "given": "Nastaran", "initials": "N", "orcid": "0000-0001-9564-325X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dade1d8864584096b8ae0c4e8d3e2653.json"}}, {"family": "Ghanbarzehi", "given": "Nezar", "initials": "N"}, {"family": "Shahkaramzehi", "given": "Zarkhatoon", "initials": "Z"}, {"family": "Sabagh", "given": "Kimya", "initials": "K"}, {"family": "Rohani", "given": "Camelia", "initials": "C"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "J Res Nurs", "issn": "1744-988X", "volume": "27", "issue": "4", "pages": "313-327", "issn-l": null}, "abstract": "COVID-19 is an infectious disease caused by a novel Coronavirus which transmits from person to person throughout the world. This study aimed to explore the lived experiences of nurses' caring for patients with COVID-2019 in the context of the healthcare system of Iran.\n\nThis is a phenomenological study with 13 participant nurses (6 men and 7 women) who were caring for COVID-19 patients in one of the university hospitals in Southeast of Iran. Qualitative data were analysed by the seven steps of Colaizzi's method.\n\nParticipants reported around a five-month history of caring for COVID-19 patients. After analysis, 597 codes, 16 categories, four sub-themes, and one theme were extracted. \"Caring from self-sacrifice to avoidance\" was the main theme of the study with sub-themes of \"Anxiety Chain\", \"Manifestation of Humanitarian Caring\", \"Ethical Challenges\", and \"Challenges of Overcoming Crisis\".\n\nNurses explained their caring experiences with patients on a continuum from humanitarian caring and self-sacrifice to caring avoidance. Because of the multi-sources of psychological stress and ethical challenges together with this infection, healthcare managers should plan for holistic regular psychological support services, prevention of job inequalities, and do strategic planning for access to enough resources in the healthcare system.", "doi": "10.1177/17449871221079175", "pmid": "35837262", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1177_17449871221079175"}, {"db": "pmc", "key": "PMC9272502"}], "notes": [], "created": "2022-08-12T08:59:13.287Z", "modified": "2022-08-12T08:59:13.361Z"}, {"entity": "publication", "iuid": "993a589aaded439bbb88d6ff12b792cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/993a589aaded439bbb88d6ff12b792cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/993a589aaded439bbb88d6ff12b792cb"}}, "title": "Neutralisation sensitivity of the SARS-CoV-2 omicron (B.1.1.529) variant: a cross-sectional study.", "authors": [{"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Kim", "given": "Changil", "initials": "C"}, {"family": "Ehling", "given": "Roy A", "initials": "RA"}, {"family": "Pankow", "given": "Alec", "initials": "A"}, {"family": "Castro Dopico", "given": "Xaquin", "initials": "X"}, {"family": "Dyrdak", "given": "Robert", "initials": "R", "orcid": "0000-0001-8456-4898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98ad76a0e144478cb3ceabd05c9928b0.json"}}, {"family": "Martin", "given": "Darren P", "initials": "DP"}, {"family": "Reddy", "given": "Sai T", "initials": "ST"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Murrell", "given": "Ben", "initials": "B"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "issn-l": null, "volume": "22", "issue": "6", "pages": "813-820"}, "abstract": "The SARS-CoV-2 omicron (B.1.1.529) variant, which was first identified in November, 2021, spread rapidly in many countries, with a spike protein highly diverged from previously known variants, and raised concerns that this variant might evade neutralising antibody responses. We therefore aimed to characterise the sensitivity of the omicron variant to neutralisation.\n\nFor this cross-sectional study, we cloned the sequence encoding the omicron spike protein from a diagnostic sample to establish an omicron pseudotyped virus neutralisation assay. We quantified the neutralising antibody ID50 (the reciprocal dilution that produces 50% inhibition) against the omicron spike protein, and the fold-change in ID50 relative to the spike of wild-type SARS-CoV-2 (ie, the pandemic founder variant), for one convalescent reference plasma pool (WHO International Standard for anti-SARS-CoV-2 immunoglobulin [20/136]), three reference serum pools from vaccinated individuals, and two cohorts from Stockholm, Sweden: one comprising previously infected hospital workers (17 sampled in November, 2021, after vaccine rollout and nine in June or July, 2020, before vaccination) and one comprising serum from 40 randomly sampled blood donors donated during week 48 (Nov 29-Dec 5) of 2021. Furthermore, we assessed the neutralisation of omicron by five clinically relevant monoclonal antibodies (mAbs).\n\nNeutralising antibody responses in reference sample pools sampled shortly after infection or vaccination were substantially less potent against the omicron variant than against wild-type SARS-CoV-2 (seven-fold to 42-fold reduction in ID50 titres). Similarly, for sera obtained before vaccination in 2020 from a cohort of convalescent hospital workers, neutralisation of the omicron variant was low to undetectable (all ID50 titres <20). However, in serum samples obtained in 2021 from two cohorts in Stockholm, substantial cross-neutralisation of the omicron variant was observed. Sera from 17 hospital workers after infection and subsequent vaccination had a reduction in average potency of only five-fold relative to wild-type SARS-CoV-2 (geometric mean ID50 titre 495 vs 105), and two donors had no reduction in potency. A similar pattern was observed in randomly sampled blood donors (n=40), who had an eight-fold reduction in average potency against the omicron variant compared with wild-type SARS-CoV-2 (geometric mean ID50 titre 369 vs 45). We found that the omicron variant was resistant to neutralisation (50% inhibitory concentration [IC50] >10 \u03bcg/mL) by mAbs casirivimab (REGN-10933), imdevimab (REGN-10987), etesevimab (Ly-CoV016), and bamlanivimab (Ly-CoV555), which form part of antibody combinations used in the clinic to treat COVID-19. However, S309, the parent of sotrovimab, retained most of its activity, with only an approximately two-fold reduction in potency against the omicron variant compared with ancestral D614G SARS-CoV-2 (IC50 0\u00b71-0\u00b72 \u03bcg/mL).\n\nThese data highlight the extensive, but incomplete, evasion of neutralising antibody responses by the omicron variant, and suggest that boosting with licensed vaccines might be sufficient to raise neutralising antibody titres to protective levels.\n\nEuropean Union Horizon 2020 research and innovation programme, European and Developing Countries Clinical Trials Partnership, SciLifeLab, and the Erling-Persson Foundation.", "doi": "10.1016/S1473-3099(22)00129-3", "pmid": "35305699", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Omicron VoC": null}, "xrefs": [{"db": "pmc", "key": "PMC8930016"}, {"db": "pii", "key": "S1473-3099(22)00129-3"}], "notes": [], "created": "2022-01-21T16:18:07.075Z", "modified": "2023-06-19T14:45:01.450Z"}, {"entity": "publication", "iuid": "bfb6d404efd348beb404a6db8b205e69", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bfb6d404efd348beb404a6db8b205e69.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bfb6d404efd348beb404a6db8b205e69"}}, "title": "Modelling: Understanding pandemics and how to control them.", "authors": [{"family": "Marion", "given": "Glenn", "initials": "G"}, {"family": "Hadley", "given": "Liza", "initials": "L"}, {"family": "Isham", "given": "Valerie", "initials": "V"}, {"family": "Mollison", "given": "Denis", "initials": "D"}, {"family": "Panovska-Griffiths", "given": "Jasmina", "initials": "J"}, {"family": "Pellis", "given": "Lorenzo", "initials": "L"}, {"family": "Tomba", "given": "Gianpaolo Scalia", "initials": "GS"}, {"family": "Scarabel", "given": "Francesca", "initials": "F"}, {"family": "Swallow", "given": "Ben", "initials": "B"}, {"family": "Trapman", "given": "Pieter", "initials": "P", "orcid": "0000-0003-0569-1659", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a2df9c9216143cd8219de8687414709.json"}}, {"family": "Villela", "given": "Daniel", "initials": "D"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Epidemics", "issn": "1878-0067", "volume": "39", "pages": "100588", "issn-l": null}, "abstract": "New disease challenges, societal demands and better or novel types of data, drive innovations in the structure, formulation and analysis of epidemic models. Innovations in modelling can lead to new insights into epidemic processes and better use of available data, yielding improved disease control and stimulating collection of better data and new data types. Here we identify key challenges for the structure, formulation, analysis and use of mathematical models of pathogen transmission relevant to current and future pandemics.", "doi": "10.1016/j.epidem.2022.100588", "pmid": "35679714", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1755-4365(22)00035-4"}], "notes": [], "created": "2022-06-20T19:29:13.358Z", "modified": "2023-06-19T15:26:45.081Z"}, {"entity": "publication", "iuid": "866944d064874e18a373935bdfbc15c2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/866944d064874e18a373935bdfbc15c2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/866944d064874e18a373935bdfbc15c2"}}, "title": "Modelling preventive measures and their effect on generation times in emerging epidemics.", "authors": [{"family": "Favero", "given": "Martina", "initials": "M", "orcid": "0000-0002-7069-9721", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2db3da80e42141af9f697718f71caa5a.json"}}, {"family": "Scalia Tomba", "given": "Gianpaolo", "initials": "G", "orcid": "0000-0001-6581-8661", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dae7fb6267504aff8ca1f6a05c0b40aa.json"}}, {"family": "Britton", "given": "Tom", "initials": "T", "orcid": "0000-0002-9228-7357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3953e83bbffb428ab0a02f335979acb2.json"}}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "J R Soc Interface", "issn": "1742-5662", "volume": "19", "issue": "191", "pages": "20220128", "issn-l": null}, "abstract": "We present a stochastic epidemic model to study the effect of various preventive measures, such as uniform reduction of contacts and transmission, vaccination, isolation, screening and contact tracing, on a disease outbreak in a homogeneously mixing community. The model is based on an infectivity process, which we define through stochastic contact and infectiousness processes, so that each individual has an independent infectivity profile. In particular, we monitor variations of the reproduction number and of the distribution of generation times. We show that some interventions, i.e. uniform reduction and vaccination, affect the former while leaving the latter unchanged, whereas other interventions, i.e. isolation, screening and contact tracing, affect both quantities. We provide a theoretical analysis of the variation of these quantities, and we show that, in practice, the variation of the generation time distribution can be significant and that it can cause biases in the estimation of reproduction numbers. The framework, because of its general nature, captures the properties of many infectious diseases, but particular emphasis is on COVID-19, for which numerical results are provided.", "doi": "10.1098/rsif.2022.0128", "pmid": "35702865", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9198515"}], "notes": [], "created": "2022-06-20T18:13:38.873Z", "modified": "2022-08-17T13:01:07.267Z"}, {"entity": "publication", "iuid": "e712b712c9b54d0e93648c3e905903b6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e712b712c9b54d0e93648c3e905903b6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e712b712c9b54d0e93648c3e905903b6"}}, "title": "Impact of COVID-19 on palliative care of cancer patients: Perspectives from Pakistan.", "authors": [{"family": "Saeed", "given": "Sajeel", "initials": "S"}, {"family": "Tousif", "given": "Kashif", "initials": "K"}, {"family": "Fatir", "given": "Chaudhary Abdul", "initials": "CA"}, {"family": "Basit", "given": "Jawad", "initials": "J"}, {"family": "Lee", "given": "Ka Yiu", "initials": "KY"}, {"family": "Tahir", "given": "Muhammad Junaid", "initials": "MJ"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Ann Med Surg (Lond)", "issn": "2049-0801", "volume": "78", "pages": "103705", "issn-l": null}, "abstract": "The COVID-19 pandemic has adversely affected the survival rate and palliative care of cancer patients all over the globe. In Pakistan, there are only a few institutions and organizations which provide specialized facilities for palliative care. During the pandemic, these specialized facilities were further limited. As only less than one percent of people had access to palliative care across Pakistan in the pandemic, the situation can be improved by establishing more such departments, providing telemedicine, increasing social media campaigns, and highlighting the importance of palliative care among cancer patients.", "doi": "10.1016/j.amsu.2022.103705", "pmid": "35582458", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2049-0801(22)00465-4"}, {"db": "pmc", "key": "PMC9098974"}], "notes": [], "created": "2022-06-21T18:03:47.165Z", "modified": "2022-06-21T18:03:47.182Z"}, {"entity": "publication", "iuid": "981bd96ab70447d18b1d57b7dc047104", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/981bd96ab70447d18b1d57b7dc047104.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/981bd96ab70447d18b1d57b7dc047104"}}, "title": "Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19.", "authors": [{"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Grip", "given": "Jonathan", "initials": "J"}, {"family": "Lindel\u00f6f", "given": "Linnea", "initials": "L", "orcid": "0000-0002-3654-8874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b0581b9ebda046fdaf4b3c14b0b910a9.json"}}, {"family": "Rooijackers", "given": "Olav", "initials": "O"}, {"family": "Pigazzini", "given": "Sara", "initials": "S"}, {"family": "Niemi", "given": "Mari", "initials": "M"}, {"family": "Cordioli", "given": "Mattia", "initials": "M"}, {"family": "Nkambule", "given": "Lindo", "initials": "L"}, {"family": "Maricic", "given": "Tomislav", "initials": "T"}, {"family": "Ekdahl", "given": "Kristina Nilsson", "initials": "KN"}, {"family": "Nilsson", "given": "Bo", "initials": "B"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ee1510080704cf6a2a6972deb94123f.json"}}, {"family": "Eriksson", "given": "Oskar", "initials": "O", "orcid": "0000-0003-2418-6463", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d2b881e96504b58a64ea3fd004c5d18.json"}}], "type": "letter", "published": "2022-06-00", "journal": {"title": "Nat Immunol", "issn": "1529-2916", "issn-l": null, "volume": "23", "issue": "6", "pages": "861-864"}, "abstract": null, "doi": "10.1038/s41590-022-01227-w", "pmid": "35624204", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41590-022-01227-w"}], "notes": [], "created": "2022-06-21T17:43:29.723Z", "modified": "2022-08-19T12:34:29.000Z"}, {"entity": "publication", "iuid": "d96a9d8d55d344d19b36ea7aeb1f78f5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d96a9d8d55d344d19b36ea7aeb1f78f5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d96a9d8d55d344d19b36ea7aeb1f78f5"}}, "title": "Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study.", "authors": [{"family": "Greco", "given": "Massimiliano", "initials": "M", "orcid": "0000-0003-1003-4637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a25a0febf83948fc8d35a2e4122f321c.json"}}, {"family": "De Corte", "given": "Thomas", "initials": "T", "orcid": "0000-0001-5011-6640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5901255b86c34191815e106debb8a64c.json"}}, {"family": "Ercole", "given": "Ari", "initials": "A", "orcid": "0000-0001-8350-8093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3aaf57ce5a454b7aa5343bbc0462d85b.json"}}, {"family": "Antonelli", "given": "Massimo", "initials": "M", "orcid": "0000-0003-3007-1670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9cdf5e76c1ee43a896a77d6055ae6a10.json"}}, {"family": "Azoulay", "given": "Elie", "initials": "E", "orcid": "0000-0002-8162-1508", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be149aab02dd48498b6b008e119f9946.json"}}, {"family": "Citerio", "given": "Giuseppe", "initials": "G", "orcid": "0000-0002-5374-3161", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/629ff9a17f4647e5af326467b1252214.json"}}, {"family": "Morris", "given": "Andy Conway", "initials": "AC", "orcid": "0000-0002-3211-3216", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f541174f24a5466e96a094b94e42de72.json"}}, {"family": "De Pascale", "given": "Gennaro", "initials": "G", "orcid": "0000-0002-8255-0676", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7866bbe8ae614536bb2a80070212035d.json"}}, {"family": "Duska", "given": "Frantisek", "initials": "F", "orcid": "0000-0003-1559-4078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e34c8d87b5f491ba0e1cd8760db70b0.json"}}, {"family": "Elbers", "given": "Paul", "initials": "P", "orcid": "0000-0003-0447-6893", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dec9d09090cb428bbbbc3a90bf5b1ab1.json"}}, {"family": "Einav", "given": "Sharon", "initials": "S", "orcid": "0000-0001-8963-9633", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7741185472c46dcac6fc1cf5c6b9083.json"}}, {"family": "Forni", "given": "Lui", "initials": "L", "orcid": "0000-0002-0617-5309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33324a9a38a94578acb4522d84c2ded6.json"}}, {"family": "Galarza", "given": "Laura", "initials": "L", "orcid": "0000-0002-4658-748X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82e734919a2045e480995be7adab3fed.json"}}, {"family": "Girbes", "given": "Armand R J", "initials": "ARJ", "orcid": "0000-0002-0711-0494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/879982b05a1848e39c9d5f0fbde801ec.json"}}, {"family": "Grasselli", "given": "Giacomo", "initials": "G", "orcid": "0000-0002-1735-1400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a68eafa11dae413bb14842cfb8647144.json"}}, {"family": "Gusarov", "given": "Vitaly", "initials": "V", "orcid": "0000-0002-2900-1459", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/896c47a24ca94c99b7fa50513fc9387b.json"}}, {"family": "Jubb", "given": "Alasdair", "initials": "A", "orcid": "0000-0001-5593-866X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2d88d0265f54a06aea8ebdf39e2df86.json"}}, {"family": "Kesecioglu", "given": "Jozef", "initials": "J", "orcid": "0000-0002-3007-8445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9af039f78ddc46b29b25b2b337c8a01e.json"}}, {"family": "Lavinio", "given": "Andrea", "initials": "A", "orcid": "0000-0002-8832-918X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a358df8988744dd99f5aecaac0e4a850.json"}}, {"family": "Delgado", "given": "Maria Cruz Martin", "initials": "MCM", "orcid": "0000-0002-7468-4594", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7eef2e9011c4281b952175a824b9f4a.json"}}, {"family": "Mellinghoff", "given": "Johannes", "initials": "J", "orcid": "0000-0002-5455-8953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37ddf15c796a4c2ea172764a6c36f9d0.json"}}, {"family": "Myatra", "given": "Sheila Nainan", "initials": "SN", "orcid": "0000-0001-6761-163X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80f906419daa4f5e87a1c6f7a9b554af.json"}}, {"family": "Ostermann", "given": "Marlies", "initials": "M", "orcid": "0000-0001-9500-9080", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc42fc57504149a29d3ffef5efd9852c.json"}}, {"family": "Pellegrini", "given": "Mariangela", "initials": "M", "orcid": "0000-0001-5668-7399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/97386683452a4afd9e1da948bb9921f2.json"}}, {"family": "Povoa", "given": "Pedro", "initials": "P", "orcid": "0000-0002-7069-7304", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93f2b9dbca90480eb98555b44c69ef58.json"}}, {"family": "Schaller", "given": "Stefan J", "initials": "SJ", "orcid": "0000-0002-6683-9584", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5c134bb75e14b94bc723f59b7dd790e.json"}}, {"family": "Teboul", "given": "Jean-Louis", "initials": "JL", "orcid": "0000-0002-5748-7820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbd174ebc7444e769fc5fd03e9689c21.json"}}, {"family": "Wong", "given": "Adrian", "initials": "A", "orcid": "0000-0003-4968-7328", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/338f961fbb48481f893f697e5dfc1d67.json"}}, {"family": "De Waele", "given": "Jan J", "initials": "JJ", "orcid": "0000-0003-1017-9748", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/875fffe346d548b19bd3c0e0ff6fb267.json"}}, {"family": "Cecconi", "given": "Maurizio", "initials": "M", "orcid": "0000-0002-4376-6538", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79162e2a5da843ee9de35265eacc1d93.json"}}, {"family": "ESICM UNITE-COVID investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "volume": "48", "issue": "6", "pages": "690-705", "issn-l": "0342-4642"}, "abstract": "To accommodate the unprecedented number of critically ill patients with pneumonia caused by coronavirus disease 2019 (COVID-19) expansion of the capacity of intensive care unit (ICU) to clinical areas not previously used for critical care was necessary. We describe the global burden of COVID-19 admissions and the clinical and organizational characteristics associated with outcomes in critically ill COVID-19 patients.\n\nMulticenter, international, point prevalence study, including adult patients with SARS-CoV-2 infection confirmed by polymerase chain reaction (PCR) and a diagnosis of COVID-19 admitted to ICU between February 15th and May 15th, 2020.\n\n4994 patients from 280 ICUs in 46 countries were included. Included ICUs increased their total capacity from 4931 to 7630 beds, deploying personnel from other areas. Overall, 1986 (39.8%) patients were admitted to surge capacity beds. Invasive ventilation at admission was present in 2325 (46.5%) patients and was required during ICU stay in 85.8% of patients. 60-day mortality was 33.9% (IQR across units: 20%-50%) and ICU mortality 32.7%. Older age, invasive mechanical ventilation, and acute kidney injury (AKI) were associated with increased mortality. These associations were also confirmed specifically in mechanically ventilated patients. Admission to surge capacity beds was not associated with mortality, even after controlling for other factors.\n\nICUs responded to the increase in COVID-19 patients by increasing bed availability and staff, admitting up to 40% of patients in surge capacity beds. Although mortality in this population was high, admission to a surge capacity bed was not associated with increased mortality. Older age, invasive mechanical ventilation, and AKI were identified as the strongest predictors of mortality.", "doi": "10.1007/s00134-022-06705-1", "pmid": "35596752", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-022-06705-1"}, {"db": "pmc", "key": "PMC9123859"}], "notes": [], "created": "2022-06-21T17:59:43.200Z", "modified": "2022-06-21T17:59:44.237Z"}, {"entity": "publication", "iuid": "eadd3298440b494c933cb8991a2e96c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eadd3298440b494c933cb8991a2e96c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eadd3298440b494c933cb8991a2e96c0"}}, "title": "An early warning system for emerging SARS-CoV-2 variants.", "authors": [{"family": "Subissi", "given": "Lorenzo", "initials": "L", "orcid": "0000-0001-5147-575X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/454c226e834a4829a330df1c4b604855.json"}}, {"family": "von Gottberg", "given": "Anne", "initials": "A", "orcid": "0000-0002-0243-7455", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa3e854c50af4dbeb6b3c51c8feca226.json"}}, {"family": "Thukral", "given": "Lipi", "initials": "L"}, {"family": "Worp", "given": "Nathalie", "initials": "N"}, {"family": "Oude Munnink", "given": "Bas B", "initials": "BB", "orcid": "0000-0002-9394-1189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19923669d04a47ebb5c7c93d20ecedc3.json"}}, {"family": "Rathore", "given": "Surabhi", "initials": "S"}, {"family": "Abu-Raddad", "given": "Laith J", "initials": "LJ", "orcid": "0000-0003-0790-0506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebbd58612cec4b76aa8f00efc37adefb.json"}}, {"family": "Aguilera", "given": "Ximena", "initials": "X", "orcid": "0000-0002-8153-6733", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be3f762e99094b86b5873d7b44d24a03.json"}}, {"family": "Alm", "given": "Erik", "initials": "E"}, {"family": "Archer", "given": "Brett N", "initials": "BN", "orcid": "0000-0002-4144-1094", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3fb24f334b94306aa5d64c193980852.json"}}, {"family": "Attar Cohen", "given": "Homa", "initials": "H"}, {"family": "Barakat", "given": "Amal", "initials": "A"}, {"family": "Barclay", "given": "Wendy S", "initials": "WS", "orcid": "0000-0002-3948-0895", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a6c3e7314d645c09435f54ee0e6046d.json"}}, {"family": "Bhiman", "given": "Jinal N", "initials": "JN", "orcid": "0000-0001-6354-4003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a8c04d1addc4cbd9bc0624e709c5fb6.json"}}, {"family": "Caly", "given": "Leon", "initials": "L"}, {"family": "Chand", "given": "Meera", "initials": "M"}, {"family": "Chen", "given": "Mark", "initials": "M"}, {"family": "Cullinane", "given": "Ann", "initials": "A"}, {"family": "de Oliveira", "given": "Tulio", "initials": "T"}, {"family": "Drosten", "given": "Christian", "initials": "C", "orcid": "0000-0001-7923-0519", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5181b233d41d4c708b9dce7e74e22f6d.json"}}, {"family": "Druce", "given": "Julian", "initials": "J"}, {"family": "Effler", "given": "Paul", "initials": "P"}, {"family": "El Masry", "given": "Ihab", "initials": "I"}, {"family": "Faye", "given": "Adama", "initials": "A"}, {"family": "Gaseitsiwe", "given": "Simani", "initials": "S"}, {"family": "Ghedin", "given": "Elodie", "initials": "E", "orcid": "0000-0002-1515-725X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ffc96a3fefb4b158fbdc240b18d5149.json"}}, {"family": "Grant", "given": "Rebecca", "initials": "R"}, {"family": "Haagmans", "given": "Bart L", "initials": "BL", "orcid": "0000-0001-6221-2015", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96a8b5e7b73b4998a3c4da5af2181538.json"}}, {"family": "Herring", "given": "Belinda L", "initials": "BL"}, {"family": "Iyer", "given": "Shilpa S", "initials": "SS"}, {"family": "Kassamali", "given": "Zyleen", "initials": "Z", "orcid": "0000-0002-0668-7099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a23574374f264895b8e0ccc9141ec987.json"}}, {"family": "Kakkar", "given": "Manish", "initials": "M", "orcid": "0000-0002-3254-0496", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c3289180dbad4089ab3e557fe14174c8.json"}}, {"family": "Kondor", "given": "Rebecca J", "initials": "RJ"}, {"family": "Leite", "given": "Juliana A", "initials": "JA", "orcid": "0000-0002-8620-114X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0ef59c86dbb441594c9bb03f9083122.json"}}, {"family": "Leo", "given": "Yee-Sin", "initials": "YS", "orcid": "0000-0003-4978-5825", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ca28661a9df44a7b95577da156b54c9.json"}}, {"family": "Leung", "given": "Gabriel M", "initials": "GM"}, {"family": "Marklewitz", "given": "Marco", "initials": "M", "orcid": "0000-0003-1828-8770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08f8a32079f24efb8e4850ac02019606.json"}}, {"family": "Moyo", "given": "Sikhulile", "initials": "S", "orcid": "0000-0003-3821-4592", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24e198ad74e84883a5d79eb36c8df68c.json"}}, {"family": "Mendez-Rico", "given": "Jairo", "initials": "J"}, {"family": "Melhem", "given": "Nada M", "initials": "NM", "orcid": "0000-0002-5423-4908", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80d02c8de4a74f268f26ef9ef1079845.json"}}, {"family": "Munster", "given": "Vincent", "initials": "V", "orcid": "0000-0002-2288-3196", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1f2569e7fe5442d968b3d89c88599d1.json"}}, {"family": "Nahapetyan", "given": "Karen", "initials": "K"}, {"family": "Oh", "given": "Djin-Ye", "initials": "DY"}, {"family": "Pavlin", "given": "Boris I", "initials": "BI"}, {"family": "Peacock", "given": "Thomas P", "initials": "TP", "orcid": "0000-0001-7077-2928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/940835adb42b431a882f9af9acf166f7.json"}}, {"family": "Peiris", "given": "Malik", "initials": "M", "orcid": "0000-0001-8217-5995", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9395f3f6fc44427b0dbf04988bfde22.json"}}, {"family": "Peng", "given": "Zhibin", "initials": "Z"}, {"family": "Poon", "given": "Leo L M", "initials": "LLM", "orcid": "0000-0002-9101-7953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6595eec1d268410fad9018a8c7dd20c6.json"}}, {"family": "Rambaut", "given": "Andrew", "initials": "A", "orcid": "0000-0003-4337-3707", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d25e62e17c243f3ab72304ca504e296.json"}}, {"family": "Sacks", "given": "Jilian", "initials": "J"}, {"family": "Shen", "given": "Yinzhong", "initials": "Y"}, {"family": "Siqueira", "given": "Marilda M", "initials": "MM"}, {"family": "Tessema", "given": "Sofonias K", "initials": "SK"}, {"family": "Volz", "given": "Erik M", "initials": "EM", "orcid": "0000-0001-6268-8937", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9be67903cdcf4953b8905562984517e8.json"}}, {"family": "Thiel", "given": "Volker", "initials": "V", "orcid": "0000-0002-5783-0887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c6d7b184da743e5975d3009cad5a802.json"}}, {"family": "van der Werf", "given": "Sylvie", "initials": "S", "orcid": "0000-0002-1148-4456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/610e999fc3fa4d24aceecf5a13122ecf.json"}}, {"family": "Briand", "given": "Sylvie", "initials": "S"}, {"family": "Perkins", "given": "Mark D", "initials": "MD"}, {"family": "Van Kerkhove", "given": "Maria D", "initials": "MD", "orcid": "0000-0002-6135-0018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/217da117247b46428c2f5ea15c3f1bf9.json"}}, {"family": "Koopmans", "given": "Marion P G", "initials": "MPG", "orcid": "0000-0002-5204-2312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80d7f1e97b934289b7095013ef6e998d.json"}}, {"family": "Agrawal", "given": "Anurag", "initials": "A"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "volume": "28", "issue": "6", "pages": "1110-1115", "issn-l": "1078-8956"}, "abstract": null, "doi": "10.1038/s41591-022-01836-w", "pmid": "35637337", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-022-01836-w"}], "notes": [], "created": "2022-06-21T17:38:16.669Z", "modified": "2022-06-21T17:38:32.806Z"}, {"entity": "publication", "iuid": "c7a44b6b483f4fe0a665c19900fdacb3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7a44b6b483f4fe0a665c19900fdacb3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7a44b6b483f4fe0a665c19900fdacb3"}}, "title": "The chimera of S1 and N proteins of SARS-CoV-2: can it be a potential vaccine candidate for COVID-19?", "authors": [{"family": "Kumar", "given": "Amresh", "initials": "A"}, {"family": "Ladha", "given": "Amit", "initials": "A"}, {"family": "Choudhury", "given": "Ankita", "initials": "A"}, {"family": "Ikbal", "given": "Abu Md Ashif", "initials": "AMA"}, {"family": "Bhattacharjee", "given": "Bedanta", "initials": "B"}, {"family": "Das", "given": "Tanmay", "initials": "T"}, {"family": "Gupta", "given": "Gaurav", "initials": "G"}, {"family": "Sharma", "given": "Chhavi", "initials": "C"}, {"family": "Sarbajna", "given": "Adity", "initials": "A"}, {"family": "Mandal", "given": "Subhash C", "initials": "SC"}, {"family": "Choudhury", "given": "Manabendra Dutta", "initials": "MD"}, {"family": "Ali", "given": "Nahid", "initials": "N"}, {"family": "Slama", "given": "Petr", "initials": "P"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Palit", "given": "Partha", "initials": "P"}, {"family": "Tiwari", "given": "Onkar Nath", "initials": "ON"}], "type": "journal article", "published": "2022-05-31", "journal": {"title": "Expert Rev Vaccines", "issn": "1744-8395", "pages": "1-16", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as one of the biggest global health issues. Spike protein (S) and nucleoprotein (N), the major immunogenic components of SARS-CoV-2, have been shown to be involved in the attachment and replication of the virus inside the host cell.\n\nSeveral investigations have shown that the SARS-CoV-2 nucleoprotein can elicit a cell-mediated immune response capable of regulating viral replication and lowering viral burden. However, the development of an effective vaccine that can stop the transmission of SARS-CoV-2 remains a matter of concern. Literature was retrieved using the keywords COVID-19 vaccine, role of nucleoprotein as vaccine candidate, spike protein, nucleoprotein immune responses against SARS-CoV-2, and chimera vaccine in PubMed, Google Scholar, and Google.\n\nWe have focussed on the use of chimera protein, consisting of N and S-1 protein components of SARS-CoV-2, as a potential vaccine candidate. This may act as a polyvalent mixed recombinant protein vaccine to elicit a strong T and B cell immune response, which will be capable of neutralizing the wild and mutated variants of SARS-CoV-2, and also restricting its attachment, replication, and budding in the host cell.", "doi": "10.1080/14760584.2022.2081156", "pmid": "35604776", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T17:53:36.946Z", "modified": "2022-06-21T17:53:36.980Z"}, {"entity": "publication", "iuid": "1595cf333fbb4fde88159a514e865a3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1595cf333fbb4fde88159a514e865a3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1595cf333fbb4fde88159a514e865a3d"}}, "title": "Guidelines for Perioperative Care in Elective Abdominal and Pelvic Surgery at Primary and Secondary Hospitals in Low-Middle-Income Countries (LMIC's): Enhanced Recovery After Surgery (ERAS) Society Recommendation.", "authors": [{"family": "Oodit", "given": "Ravi", "initials": "R"}, {"family": "Biccard", "given": "Bruce M", "initials": "BM"}, {"family": "Panieri", "given": "Eugenio", "initials": "E"}, {"family": "Alvarez", "given": "Adrian O", "initials": "AO"}, {"family": "Sioson", "given": "Marianna R S", "initials": "MRS"}, {"family": "Maswime", "given": "Salome", "initials": "S"}, {"family": "Thomas", "given": "Viju", "initials": "V"}, {"family": "Kluyts", "given": "Hyla-Louise", "initials": "HL"}, {"family": "Peden", "given": "Carol J", "initials": "CJ"}, {"family": "de Boer", "given": "Hans D", "initials": "HD"}, {"family": "Brindle", "given": "Mary", "initials": "M"}, {"family": "Francis", "given": "Nader K", "initials": "NK"}, {"family": "Nelson", "given": "Gregg", "initials": "G"}, {"family": "Gustafsson", "given": "Ulf O", "initials": "UO"}, {"family": "Ljungqvist", "given": "Olle", "initials": "O"}], "type": "journal article", "published": "2022-05-31", "journal": {"title": "World J Surg", "issn": "1432-2323", "issn-l": null}, "abstract": "This is the first Enhanced Recovery After Surgery (ERAS\u00ae) Society guideline for primary and secondary hospitals in low-middle-income countries (LMIC's) for elective abdominal and gynecologic care.\n\nThe ERAS LMIC Guidelines group was established by the ERAS\u00ae Society in collaboration with different representatives of perioperative care from LMIC's. The group consisted of seven members from the ERAS\u00ae Society and eight members from LMIC's. An updated systematic literature search and evaluation of evidence from previous ERAS\u00ae guidelines was performed by the leading authors of the Colorectal (2018) and Gynecologic (2019) surgery guidelines (Gustafsson et al in World J Surg 43:6592-695, Nelson et al in Int J Gynecol Cancer 29(4):651-668). Meta-analyses randomized controlled trials (RCTs), prospective and retrospective cohort studies from both HIC's and LMIC's were considered for each perioperative item. The members in the LMIC group then applied the current evidence and adapted the recommendations for each intervention as well as identifying possible new items relevant to LMIC's. The Grading of Recommendations, Assessment, Development and Evaluation system (GRADE) methodology was used to determine the quality of the published evidence. The strength of the recommendations was based on importance of the problem, quality of evidence, balance between desirable and undesirable effects, acceptability to key stakeholders, cost of implementation and specifically the feasibility of implementing in LMIC's and determined through discussions and consensus.\n\nIn addition to previously described ERAS\u00ae Society interventions, the following items were included, revised or discussed: the Surgical Safety Checklist (SSC), preoperative routine human immunodeficiency virus (HIV) testing in countries with a high prevalence of HIV/AIDS (CD4 and viral load for those patients that are HIV positive), delirium screening and prevention, COVID 19 screening, VTE prophylaxis, immuno-nutrition, prehabilitation, minimally invasive surgery (MIS) and a standardized postoperative monitoring guideline.\n\nThese guidelines are seen as a starting point to address the urgent need to improve perioperative care and to effect data-driven, evidence-based care in LMIC's.", "doi": "10.1007/s00268-022-06587-w", "pmid": "35641574", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00268-022-06587-w"}], "notes": [], "created": "2022-06-21T17:36:07.435Z", "modified": "2022-06-21T17:36:07.451Z"}, {"entity": "publication", "iuid": "07dd3b7e73b048b29dc9036d4ed4561b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07dd3b7e73b048b29dc9036d4ed4561b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07dd3b7e73b048b29dc9036d4ed4561b"}}, "title": "Critical Care Nurses' Experiences Caring for Patients When Relatives Were not Allowed in the ICUs due to COVID-19 Pandemic.", "authors": [{"family": "Stenman", "given": "Lina", "initials": "L"}, {"family": "H\u00f6gberg", "given": "Lisa", "initials": "L"}, {"family": "Engstr\u00f6m", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0001-6244-6401", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f93844031da44a79bc89f3d73da4477f.json"}}], "type": "journal article", "published": "2022-05-31", "journal": {"title": "SAGE Open Nurs", "issn": "2377-9608", "volume": "8", "pages": "23779608221103627", "issn-l": null}, "abstract": "Health care workers faced new challenges during the COVID-19 pandemic when physical contact with relatives more or less disappeared.\n\nThe aim of this study is to describe the experiences of critical care nurses (CCNs) working in intensive care units (ICUs) under the visiting restrictions imposed as a result of COVID-19.\n\nThis study followed a qualitative design. The purposive sample included CCNs with at least 1 year of experience working in an ICU with a visiting policy affected by the pandemic. Data collection was carried out via semi-structured interviews and analyzed through a qualitative content analysis with an inductive approach.\n\nThe study results are presented in three categories with 10 subcategories. CCNs value the presence of patients' relatives at the bedside and described many challenges when relatives could not be present with the patient during the pandemic.\n\nClose relatives are able to share essential information about the patients and provide much-needed emotional support to them, the relatives' role is of central importance and CCNs value their presence in ICUs more than any positive consequences of them not being there.", "doi": "10.1177/23779608221103627", "pmid": "35669888", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1177_23779608221103627"}, {"db": "pmc", "key": "PMC9163743"}], "notes": [], "created": "2022-06-20T19:32:37.982Z", "modified": "2022-06-20T19:32:38.037Z"}, {"entity": "publication", "iuid": "d264d65d67174ddabfb94234c528049b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d264d65d67174ddabfb94234c528049b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d264d65d67174ddabfb94234c528049b"}}, "title": "An analysis of how health systems integrated priority-setting in the pandemic planning in a sample of Latin America and the Caribbean countries.", "authors": [{"family": "V\u00e9lez", "given": "Claudia-Marcela", "initials": "CM"}, {"family": "Aguilera", "given": "Bernardo", "initials": "B"}, {"family": "Kapiriri", "given": "Lydia", "initials": "L", "orcid": "0000-0002-1237-6369", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec392c3ae33d40f096e713eaa6a2be11.json"}}, {"family": "Essue", "given": "Beverley M", "initials": "BM"}, {"family": "Nouvet", "given": "Elysee", "initials": "E"}, {"family": "Sandman", "given": "Lars", "initials": "L"}, {"family": "Williams", "given": "Iestyn", "initials": "I"}], "type": "journal article", "published": "2022-05-31", "journal": {"title": "Health Res Policy Syst", "issn": "1478-4505", "volume": "20", "issue": "1", "pages": "58", "issn-l": null}, "abstract": "Latin America and the Caribbean (LAC) are among those regions most affected by the COVID-19 pandemic worldwide. The COVID-19 pandemic has strained health systems in the region. In this context of severe healthcare resource constraints, there is a need for systematic priority-setting to support decision-making which ensures the best use of resources while considering the needs of the most vulnerable groups. The aim of this paper was to provide a critical description and analysis of how health systems considered priority-setting in the COVID-19 response and preparedness plans of a sample of 14 LAC countries; and to identify the associated research gaps.\n\nA documentary analysis of COVID-19 preparedness and response plans was performed in a sample of 14 countries in the LAC region. We assessed the degree to which the documented priority-setting processes adhered to established quality indicators of effective priority-setting included in the Kapiriri and Martin framework. We conducted a descriptive analysis of the degree to which the reports addressed the quality parameters for each individual country, as well as a cross-country comparison to explore whether parameters varied according to independent variables.\n\nWhile all plans were led and supported by the national governments, most included only a limited number of quality indicators for effective priority-setting. There was no systematic pattern between the number of quality indicators and the country's health system and political contexts; however, the countries that had the least number of quality indicators tended to be economically disadvantaged.\n\nThis study adds to the literature by providing the first descriptive analysis of the inclusion of priority-setting during a pandemic, using the case of COVID-19 response and preparedness plans in the LAC region. The analysis found that despite the strong evidence of political will and stakeholder participation, none of the plans presented a clear priority-setting process, or used a formal priority-setting framework, to define interventions, populations, geographical regions, healthcare setting or resources prioritized. There is need for case studies that analyse how priority-setting actually occurred during the COVID-19 pandemic and the degree to which the implementation reflected the plans and the parameters of effective priority-setting, as well as the impact of the prioritization processes on population health, with a focus on the most vulnerable groups.", "doi": "10.1186/s12961-022-00861-y", "pmid": "35642055", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12961-022-00861-y"}], "notes": [], "created": "2022-06-21T17:35:46.517Z", "modified": "2022-06-21T17:35:46.600Z"}, {"entity": "publication", "iuid": "6cc5cac975e84955a775563b5c242bf0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6cc5cac975e84955a775563b5c242bf0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6cc5cac975e84955a775563b5c242bf0"}}, "title": "Quality of life (QoL) among COVID-19 recovered healthcare workers in Bangladesh.", "authors": [{"family": "Rashid", "given": "Md Utba", "initials": "MU"}, {"family": "Khan", "given": "Md Abdullah Saeed", "initials": "MAS"}, {"family": "Dalal", "given": "Koustuv", "initials": "K", "orcid": "0000-0001-7393-796X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab5e44a17b7545988cb46cdf5b1f3e4e.json"}}, {"family": "Sagar", "given": "Soumik Kha", "initials": "SK"}, {"family": "Hossian", "given": "Mosharop", "initials": "M"}, {"family": "Barsha", "given": "Sabrina Yesmin", "initials": "SY"}, {"family": "Haque", "given": "Miah Md Akiful", "initials": "MMA"}, {"family": "Ali Hossain", "given": "Mohammad", "initials": "M"}, {"family": "Hayatun Nabi", "given": "Mohammad", "initials": "M"}, {"family": "Hawlader", "given": "Mohammad Delwer Hossain", "initials": "MDH"}], "type": "journal article", "published": "2022-05-30", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "volume": "22", "issue": "1", "pages": "716", "issn-l": null}, "abstract": "The Coronavirus Disease 2019 (COVID-19) caused by the SARS-CoV-2 virus has taken the lives of more than 100,000 healthcare workers (HCWs) so far. Those who survived continuously work under immense physical and psychological pressure, and their quality of life (QoL) is impacted. The study aimed to assess the QoL among HCWs in Bangladesh who recovered from COVID-19.\n\nThis cross-sectional, telephonic interview-based study was conducted among 322 randomly selected HCWs from Bangladesh who were positive for COVID-19 and recovered from the infection before the interview. Data were collected from June to November 2020. We examined the impact of COVID on the QoL of the participants using the validated Bangladesh version of the World Health Organization (WHO) Quality of life questionnaire brief (WHOQOL-BREF). All analyses were done by STATA (Version 16.1).\n\nMore than half of the health care professionals were male (56.0%), aged between 26-35 years (51%), and completed graduation (49%). The majority of the study participants in the four domains were married (n = 263, 81%) and living in Dhaka. The average score of the participants was 70.91 \u00b1 13.07, 62.68 \u00b1 14.99, 66.93 \u00b1 15.14, and 63.56 \u00b1 12.11 in physical, psychological, social relationship and environmental domains, respectively. HCWs in urban areas enjoyed 2.4 times better socially stable lives (OR: 2.42, 95% CI: 1.18-4.96) but 72% less psychologically satisfactory lives.\n\nHCWs' post-COVID quality of life depended on variable interaction of demographic socioeconomic, including old age, female sex, graduation, and higher monthly income. The findings indicate the issues which should be addressed to improve the quality of life of frontline workers who fight against the pandemic.", "doi": "10.1186/s12913-022-07961-z", "pmid": "35637475", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-022-07961-z"}], "notes": [], "created": "2022-06-21T17:36:57.103Z", "modified": "2022-06-21T17:37:33.850Z"}, {"entity": "publication", "iuid": "5e658bf185dd46ceaf587101889e1b73", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e658bf185dd46ceaf587101889e1b73.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e658bf185dd46ceaf587101889e1b73"}}, "title": "Pre-exascale HPC approaches for molecular dynamics simulations. Covid-19 research: A use case.", "authors": [{"family": "Wiecz\u00f3r", "given": "Mi\u0142osz", "initials": "M"}, {"family": "Genna", "given": "Vito", "initials": "V"}, {"family": "Aranda", "given": "Juan", "initials": "J"}, {"family": "Badia", "given": "Rosa M", "initials": "RM", "orcid": "0000-0003-2941-5499", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/118643637250473c831a71d4229a94b4.json"}}, {"family": "Gelp\u00ed", "given": "Josep Llu\u00eds", "initials": "JL"}, {"family": "Gapsys", "given": "Vytautas", "initials": "V", "orcid": "0000-0002-6761-7780", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f09aac84213f4745a30d5aa4b21d39a0.json"}}, {"family": "de Groot", "given": "Bert L", "initials": "BL"}, {"family": "Lindahl", "given": "Erik", "initials": "E"}, {"family": "Municoy", "given": "Mart\u00ed", "initials": "M", "orcid": "0000-0003-4399-153X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822616e19cea40f4a71d758873555eb6.json"}}, {"family": "Hospital", "given": "Adam", "initials": "A"}, {"family": "Orozco", "given": "Modesto", "initials": "M", "orcid": "0000-0002-8608-3278", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d51c4e79f3a4b6f90868149ffbf7daa.json"}}], "type": "journal article", "published": "2022-05-30", "journal": {"title": "Wiley Interdiscip Rev Comput Mol Sci", "issn": "1759-0876", "pages": "e1622", "issn-l": null}, "abstract": "Exascale computing has been a dream for ages and is close to becoming a reality that will impact how molecular simulations are being performed, as well as the quantity and quality of the information derived for them. We review how the biomolecular simulations field is anticipating these new architectures, making emphasis on recent work from groups in the BioExcel Center of Excellence for High Performance Computing. We exemplified the power of these simulation strategies with the work done by the HPC simulation community to fight Covid-19 pandemics. This article is categorized under:Data Science > Computer Algorithms and ProgrammingData Science > Databases and Expert SystemsMolecular and Statistical Mechanics > Molecular Dynamics and Monte-Carlo Methods.", "doi": "10.1002/wcms.1622", "pmid": "35935573", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "WCMS1622"}, {"db": "pmc", "key": "PMC9347456"}], "notes": [], "created": "2022-08-11T11:53:30.133Z", "modified": "2022-08-11T11:53:48.319Z"}, {"entity": "publication", "iuid": "9af1ae25bf344ecf94993e1aa5dab071", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9af1ae25bf344ecf94993e1aa5dab071.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9af1ae25bf344ecf94993e1aa5dab071"}}, "title": "The significance of surface neutrophilic MPO expression level in NETosis and NETosis-associated coagulopathies in covid-19 infected patients.", "authors": [{"family": "Jamali", "given": "Elham", "initials": "E"}, {"family": "Abbasi", "given": "Mojdeh", "initials": "M"}, {"family": "Tayer", "given": "Akbar Hashemi", "initials": "AH"}, {"family": "Monfared", "given": "Ali Arabi", "initials": "AA"}, {"family": "Tandel", "given": "Parisa", "initials": "P"}, {"family": "Tamaddon", "given": "Gholamhossein", "initials": "G"}, {"family": "Kazerooni", "given": "Ehsan Sarraf", "initials": "ES"}, {"family": "Rakhshandehroo", "given": "Shahrokh", "initials": "S"}, {"family": "Ranjbaran", "given": "Reza", "initials": "R"}], "type": "journal article", "published": "2022-05-29", "journal": {"title": "Blood Cells Mol Dis", "issn": "1096-0961", "volume": "96", "pages": "102676", "issn-l": null}, "abstract": "Inflammatory response-induced coagulopathy is a common complication associated with severe form of covid-19 infection. Evidences suggest that neutrophil extracellular traps (NETs) play a significant role in triggering the immunothrombosis in this condition. We aimed to evaluate the diagnostic value of surface neutrophilic myeloperoxidase (MPO) as NETosis biomarker for predicting the risk of covid-19-associated coagulopathies.\n\nCovid-19 infection was assessed by real-time-PCR and plasma d-dimer levels were measured by ELFA. Based on the covid-19 infection and d-dimer level outcomes, patients were categorized into four groups. Any alteration in the serum level of IL-6, H3Cit and neutrophilic surface MPO were analyzed by CLIA, ELISA, and flow cytometry, respectively.\n\nH3Cit variations and different d-dimer values confirmed the association between NETosis and coagulopathies. Findings showed that the expression of neutrophilic MPO reduced in cases with NETosis, which was correlated with increased levels of H3Cit. ANC/MPO ratio was signified as a valuable marker to discriminate the covid-19 and non covid-19-associated coagulopathies and could be considered as a prognostic factor due to its noteworthy correlation with serum IL-6 concentration.\n\nDeclined levels of surface neutrophilic MPO in NETosis correlate with covid-19-associated coagulopathies and increased IL-6 levels, as a potential biomarker of covid-19 disease severity.", "doi": "10.1016/j.bcmd.2022.102676", "pmid": "35661911", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1079-9796(22)00033-X"}], "notes": [], "created": "2022-06-21T17:16:55.067Z", "modified": "2022-06-21T17:16:55.097Z"}, {"entity": "publication", "iuid": "a96ded4eb17e4db38a262e53b6c1976c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a96ded4eb17e4db38a262e53b6c1976c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a96ded4eb17e4db38a262e53b6c1976c"}}, "title": "Transforming or tinkering: the world remains unprepared for the next pandemic threat.", "authors": [{"family": "Clark", "given": "Helen", "initials": "H"}, {"family": "C\u00e1rdenas", "given": "Mauricio", "initials": "M"}, {"family": "Dybul", "given": "Mark", "initials": "M"}, {"family": "Kazatchkine", "given": "Michel", "initials": "M"}, {"family": "Liu", "given": "Joanne", "initials": "J"}, {"family": "Miliband", "given": "David", "initials": "D"}, {"family": "Nordstr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Sudan", "given": "Preeti", "initials": "P"}, {"family": "Zedillo", "given": "Ernesto", "initials": "E"}, {"family": "Obaid", "given": "Thoraya", "initials": "T"}, {"family": "McCarney", "given": "Rosemary", "initials": "R"}, {"family": "Radin", "given": "Elizabeth", "initials": "E"}, {"family": "Eliasz", "given": "Mike Kalmus", "initials": "MK"}, {"family": "McNab", "given": "Christine", "initials": "C"}, {"family": "Legido-Quigley", "given": "Helena", "initials": "H"}, {"family": "Sirleaf", "given": "Ellen Johnson", "initials": "EJ"}], "type": "journal article", "published": "2022-05-28", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "399", "issue": "10340", "pages": "1995-1999", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(22)00929-1", "pmid": "35597246", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(22)00929-1"}, {"db": "pmc", "key": "PMC9114832"}], "notes": [], "created": "2022-06-21T17:58:47.542Z", "modified": "2022-06-21T17:59:16.940Z"}, {"entity": "publication", "iuid": "3232d2ae3e22401c8cbac0ff88028687", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3232d2ae3e22401c8cbac0ff88028687.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3232d2ae3e22401c8cbac0ff88028687"}}, "title": "Battling extraordinary situations and conflicting emotions-A qualitative study of being a newly graduated Registered Nurse in the emergency department during the COVID-19 pandemic.", "authors": [{"family": "Carnesten", "given": "Hillewi", "initials": "H", "orcid": "0000-0002-6512-849X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6fb875140b7345fa9e94862b866e066c.json"}}, {"family": "Wiklund Gustin", "given": "Lena", "initials": "L", "orcid": "0000-0002-9714-577X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8bcbede9d577497495130e22dd6a6c88.json"}}, {"family": "Skoglund", "given": "Karin", "initials": "K", "orcid": "0000-0001-8008-8169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e6fc2925ce9443e865e3dc39411af54.json"}}, {"family": "Von Heideken W\u00e5gert", "given": "Petra", "initials": "P", "orcid": "0000-0001-6292-7010", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4d6dfb26a37419385eb8e257f89d950.json"}}], "type": "journal article", "published": "2022-05-28", "journal": {"title": "Nurs Open", "issn": "2054-1058", "issn-l": null}, "abstract": "To describe newly graduated registered nurses' (NGRNs') experiences of encountering stress in emergency departments (EDs) during the COVID-19 pandemic.\n\nA qualitative descriptive study.\n\nData from 14 in-depth interviews with NGRNs working in an ED for 3-36 months after graduation was analysed by the means of qualitative content analysis as described by Graneheim and Lundman. Interviews were conducted from March to November 2020 covering the first two waves of the pandemic.\n\nData revealed three categories and nine subcategories comprised in the theme Battling extraordinary situations and conflicting emotions. Empowered by acknowledging themselves as important caregivers during the pandemic NGRNs struggle against limitations and exert themselves beyond their known limit. External stressors due to work overload in combination with understaffing force NGRNs into the role of the experienced nurse prematurely and internal stressors derives from part taking in less qualitative care.", "doi": "10.1002/nop2.1250", "pmid": "35633153", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T17:39:20.222Z", "modified": "2022-06-21T17:39:20.361Z"}, {"entity": "publication", "iuid": "1c4f45fce1454dd9a3156ad81c103970", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1c4f45fce1454dd9a3156ad81c103970.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1c4f45fce1454dd9a3156ad81c103970"}}, "title": "Time Trend in SARS-CoV-2 Seropositivity, Surveillance Detection- and Infection Fatality Ratio until Spring 2021 in the Tirschenreuth County-Results from a Population-Based Longitudinal Study in Germany.", "authors": [{"family": "Einhauser", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-4177-4451", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0d657959e714aa18b8cda14ae8b260d.json"}}, {"family": "Peterhoff", "given": "David", "initials": "D", "orcid": "0000-0001-5911-6233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3784a38e6f81455e9af931fae1c0b830.json"}}, {"family": "Beileke", "given": "Stephanie", "initials": "S"}, {"family": "G\u00fcnther", "given": "Felix", "initials": "F", "orcid": "0000-0001-6582-1174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b533ef33e9a4769b5ba32a0e616f5c0.json"}}, {"family": "Niller", "given": "Hans-Helmut", "initials": "HH"}, {"family": "Steininger", "given": "Philipp", "initials": "P"}, {"family": "Kn\u00f6ll", "given": "Antje", "initials": "A"}, {"family": "Korn", "given": "Klaus", "initials": "K", "orcid": "0000-0003-1891-2107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a90fec0b05a4968b6ac28e9c4b675d8.json"}}, {"family": "Berr", "given": "Melanie", "initials": "M"}, {"family": "Sch\u00fctz", "given": "Anja", "initials": "A"}, {"family": "Wiegrebe", "given": "Simon", "initials": "S"}, {"family": "Stark", "given": "Klaus J", "initials": "KJ"}, {"family": "Gessner", "given": "Andr\u00e9", "initials": "A"}, {"family": "Burkhardt", "given": "Ralph", "initials": "R", "orcid": "0000-0003-1924-1202", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4eb3b61804944e6a065c85267832d8a.json"}}, {"family": "Kabesch", "given": "Michael", "initials": "M"}, {"family": "Schedl", "given": "Holger", "initials": "H"}, {"family": "K\u00fcchenhoff", "given": "Helmut", "initials": "H"}, {"family": "Pfahlberg", "given": "Annette B", "initials": "AB", "orcid": "0000-0002-2234-1215", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5c6a8a551ed4d9e9f51afe633b3080c.json"}}, {"family": "Heid", "given": "Iris M", "initials": "IM"}, {"family": "Gefeller", "given": "Olaf", "initials": "O", "orcid": "0000-0002-8985-7582", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15905044556b4978bca8b0728c901348.json"}}, {"family": "\u00dcberla", "given": "Klaus", "initials": "K", "orcid": "0000-0001-7822-3835", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/221ba6c8276a405380303915261e3558.json"}}, {"family": "Wagner", "given": "Ralf", "initials": "R"}], "type": "journal article", "published": "2022-05-27", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "6", "issn-l": "1999-4915"}, "abstract": "Herein, we provide results from a prospective population-based longitudinal follow-up (FU) SARS-CoV-2 serosurveillance study in Tirschenreuth, the county which was hit hardest in Germany in spring 2020 and early 2021. Of 4203 individuals aged 14 years or older enrolled at baseline (BL, June 2020), 3546 participated at FU1 (November 2020) and 3391 at FU2 (April 2021). Key metrics comprising standardized seroprevalence, surveillance detection ratio (SDR), infection fatality ratio (IFR) and success of the vaccination campaign were derived using the Roche N- and S-Elecsys anti-SARS-CoV-2 test together with a self-administered questionnaire. N-seropositivity at BL was 9.2% (1st wave). While we observed a low new seropositivity between BL and FU1 (0.9%), the combined 2nd and 3rd wave accounted for 6.1% new N-seropositives between FU1 and FU2 (ever seropositives at FU2: 15.4%). The SDR decreased from 5.4 (BL) to 1.1 (FU2) highlighting the success of massively increased testing in the population. The IFR based on a combination of serology and registration data resulted in 3.3% between November 2020 and April 2021 compared to 2.3% until June 2020. Although IFRs were consistently higher at FU2 compared to BL across age-groups, highest among individuals aged 70+ (18.3% versus 10.7%, respectively), observed differences were within statistical uncertainty bounds. While municipalities with senior care homes showed a higher IFR at BL (3.0% with senior care home vs. 0.7% w/o), this effect diminished at FU2 (3.4% vs. 2.9%). In April 2021 (FU2), vaccination rate in the elderly was high (&gt;77.4%, age-group 80+).", "doi": "10.3390/v14061168", "pmid": "35746640", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "v14061168"}, {"db": "pmc", "key": "PMC9228731"}], "notes": [], "created": "2022-08-19T05:42:07.176Z", "modified": "2022-08-19T05:42:28.995Z"}, {"entity": "publication", "iuid": "82358c5f8f5d41f385b21a78b1c1cc94", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82358c5f8f5d41f385b21a78b1c1cc94.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82358c5f8f5d41f385b21a78b1c1cc94"}}, "title": "Resilience and post-traumatic growth in the transition to motherhood during the COVID-19 pandemic: A qualitative exploratory study.", "authors": [{"family": "Thomson", "given": "Gill", "initials": "G", "orcid": "0000-0003-3392-8182", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01ec0dfaaa56415eb9121e6451021640.json"}}, {"family": "Cook", "given": "Julie", "initials": "J"}, {"family": "Nowland", "given": "Rebecca", "initials": "R"}, {"family": "Donnellan", "given": "Warren James", "initials": "WJ", "orcid": "0000-0002-0224-9155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32764a489b614baeb20ac6ae07593a85.json"}}, {"family": "Topalidou", "given": "Anastasia", "initials": "A"}, {"family": "Jackson", "given": "Leanne", "initials": "L"}, {"family": "Fallon", "given": "Vicky", "initials": "V"}], "type": "journal article", "published": "2022-05-27", "journal": {"title": "Scand J Caring Sci", "issn": "1471-6712", "issn-l": null}, "abstract": "Most perinatal research relating to COVID-19 focuses on its negative impact on maternal and parental mental health. Currently, there are limited data on how to optimise positive health during the pandemic. We aimed to bridge this knowledge gap by exploring how women have adapted to becoming a new parent during the pandemic and to identify elements of resilience and growth within their narratives. Mothers of infants under the age of 4 months were recruited as part of a wider UK mixed-methods study. Semi-structured interviews with 20 mothers elicited data about how COVID-19 had influenced their transition to parent a new infant, and if and how they adapted during the pandemic, what strategies they used, and if and how these had been effective. Directed qualitative content analysis was undertaken, and pre-existing theoretical frameworks of resilience and post-traumatic growth (PTG) were used to analyse and interpret the data set. The findings show evidence of a range of resilience and PTG concepts experienced during the pandemic in this cohort. Salient resilience themes included personal (active coping, reflective functioning, and meaning-making), relational (social support, partner relationships, and family relationships), and contextual (health and social connectedness) factors. There was also evidence of PTG in terms of the potential for new work-related and leisure opportunities, and women developing wider and more meaningful connections with others. Although further research is needed, and with individuals from diverse socioeconomic backgrounds, these findings emphasise the significance of social support and connectivity as vital to positive mental health. Opportunities to increase digital innovations to connect and support new parents should be maximised to buffer the negative impacts of further social distancing and crisis situations.", "doi": "10.1111/scs.13087", "pmid": "35621069", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2022-06-21T17:45:42.061Z", "modified": "2022-06-21T17:46:19.515Z"}, {"entity": "publication", "iuid": "08da99ee2ab34869aa7cc6201fbf2cda", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/08da99ee2ab34869aa7cc6201fbf2cda.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/08da99ee2ab34869aa7cc6201fbf2cda"}}, "title": "Determination of IgG1 and IgG3 SARS-CoV-2 Spike Protein and Nucleocapsid Binding-Who Is Binding Who and Why?", "authors": [{"family": "Iles", "given": "Jason K", "initials": "JK"}, {"family": "Zmuidinaite", "given": "Raminta", "initials": "R", "orcid": "0000-0001-7728-6623", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/421ae7d6575445888ac6bb7f537b4b16.json"}}, {"family": "Sadee", "given": "Christoph", "initials": "C"}, {"family": "Gardiner", "given": "Anna", "initials": "A"}, {"family": "Lacey", "given": "Jonathan", "initials": "J"}, {"family": "Harding", "given": "Stephen", "initials": "S"}, {"family": "Wallis", "given": "Gregg", "initials": "G"}, {"family": "Patel", "given": "Roshani", "initials": "R"}, {"family": "Roblett", "given": "Debra", "initials": "D"}, {"family": "Heeney", "given": "Jonathan", "initials": "J"}, {"family": "Baxendale", "given": "Helen", "initials": "H"}, {"family": "Iles", "given": "Ray Kruse", "initials": "RK"}], "type": "journal article", "published": "2022-05-27", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "23", "issue": "11", "pages": "6050", "issn-l": null}, "abstract": "The involvement of immunoglobulin (Ig) G3 in the humoral immune response to SARS-CoV-2 infection has been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS) in COVID-19. The exact molecular mechanism is unknown, but it is thought to involve this IgG subtype's differential ability to fix, complement and stimulate cytokine release. We examined the binding of convalescent patient antibodies to immobilized nucleocapsids and spike proteins by matrix-assisted laser desorption/ionization-time of flight (MALDI-ToF) mass spectrometry. IgG3 was a major immunoglobulin found in all samples. Differential analysis of the spectral signatures found for the nucleocapsid versus the spike protein demonstrated that the predominant humoral immune response to the nucleocapsid was IgG3, whilst for the spike protein it was IgG1. However, the spike protein displayed a strong affinity for IgG3 itself, as it would bind from control plasma samples, as well as from those previously infected with SARS-CoV-2, similar to the way protein G binds IgG1. Furthermore, detailed spectral analysis indicated that a mass shift consistent with hyper-glycosylation or glycation was a characteristic of the IgG3 captured by the spike protein.", "doi": "10.3390/ijms23116050", "pmid": "35682724", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9181569"}, {"db": "pii", "key": "ijms23116050"}], "notes": [], "created": "2022-06-20T19:26:26.231Z", "modified": "2023-06-19T14:54:05.767Z"}, {"entity": "publication", "iuid": "3aa502c25f0c4b22b6f27b6881488e53", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3aa502c25f0c4b22b6f27b6881488e53.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3aa502c25f0c4b22b6f27b6881488e53"}}, "title": "Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity.", "authors": [{"family": "Batlle", "given": "Daniel", "initials": "D"}, {"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Garreta", "given": "Elena", "initials": "E"}, {"family": "Hassler", "given": "Luise", "initials": "L"}, {"family": "Wysocki", "given": "Jan", "initials": "J"}, {"family": "Chandar", "given": "Vasuretha", "initials": "V"}, {"family": "Schwartz", "given": "Robert E", "initials": "RE"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Montserrat", "given": "Nuria", "initials": "N"}, {"family": "Bader", "given": "Michael", "initials": "M"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}], "type": "letter", "published": "2022-05-26", "journal": {"title": "Cell", "issn": "1097-4172", "volume": "185", "issue": "11", "pages": "1837-1839", "issn-l": "0092-8674"}, "abstract": null, "doi": "10.1016/j.cell.2022.05.004", "pmid": "35623327", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0092-8674(22)00588-8"}], "notes": [], "created": "2022-06-21T17:44:41.930Z", "modified": "2022-06-21T17:44:41.944Z"}, {"entity": "publication", "iuid": "0e400cb9bc494d649666d89f4e9b636b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e400cb9bc494d649666d89f4e9b636b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e400cb9bc494d649666d89f4e9b636b"}}, "title": "Editorial: Platelet Function in COVID-19.", "authors": [{"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A"}, {"family": "Sand\u00e9n", "given": "Per", "initials": "P"}, {"family": "Mitroulis", "given": "Ioannis", "initials": "I"}, {"family": "van der Meijden", "given": "Paola E J", "initials": "PEJ"}], "type": "editorial", "published": "2022-05-26", "journal": {"title": "Front Cardiovasc Med", "issn": "2297-055X", "volume": "9", "pages": "912472", "issn-l": null}, "abstract": null, "doi": "10.3389/fcvm.2022.912472", "pmid": "35722094", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC9204630"}], "notes": [], "created": "2022-08-17T12:46:16.941Z", "modified": "2022-08-17T12:46:16.954Z"}, {"entity": "publication", "iuid": "7243b81f939c47b88b5e8e0ce022db0a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7243b81f939c47b88b5e8e0ce022db0a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7243b81f939c47b88b5e8e0ce022db0a"}}, "title": "Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction.", "authors": [{"family": "Guimond", "given": "Scott E", "initials": "SE"}, {"family": "Mycroft-West", "given": "Courtney J", "initials": "CJ"}, {"family": "Gandhi", "given": "Neha S", "initials": "NS", "orcid": "0000-0003-3119-6731", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78db66b38cb24a759aaed5fd1a7246e6.json"}}, {"family": "Tree", "given": "Julia A", "initials": "JA"}, {"family": "Le", "given": "Thuy T", "initials": "TT"}, {"family": "Spalluto", "given": "C Mirella", "initials": "CM"}, {"family": "Humbert", "given": "Maria V", "initials": "MV"}, {"family": "Buttigieg", "given": "Karen R", "initials": "KR"}, {"family": "Coombes", "given": "Naomi", "initials": "N"}, {"family": "Elmore", "given": "Michael J", "initials": "MJ"}, {"family": "Wand", "given": "Matthew", "initials": "M"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Said", "given": "Joanna", "initials": "J"}, {"family": "Setoh", "given": "Yin Xiang", "initials": "YX"}, {"family": "Amarilla", "given": "Alberto A", "initials": "AA"}, {"family": "Modhiran", "given": "Naphak", "initials": "N"}, {"family": "Sng", "given": "Julian D J", "initials": "JDJ"}, {"family": "Chhabra", "given": "Mohit", "initials": "M"}, {"family": "Young", "given": "Paul R", "initials": "PR"}, {"family": "Rawle", "given": "Daniel J", "initials": "DJ"}, {"family": "Lima", "given": "Marcelo A", "initials": "MA"}, {"family": "Yates", "given": "Edwin A", "initials": "EA", "orcid": "0000-0001-9365-5433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/16a88f385653436bb561e77ffc4fd73a.json"}}, {"family": "Karlsson", "given": "Richard", "initials": "R"}, {"family": "Miller", "given": "Rebecca L", "initials": "RL", "orcid": "0000-0001-8574-1948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8aae63723f184b4791e0b61f55d023fc.json"}}, {"family": "Chen", "given": "Yen-Hsi", "initials": "YH"}, {"family": "Bagdonaite", "given": "Ieva", "initials": "I", "orcid": "0000-0002-9383-8448", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5981026aabfd475787f9a79a2ea7340f.json"}}, {"family": "Yang", "given": "Zhang", "initials": "Z"}, {"family": "Stewart", "given": "James", "initials": "J"}, {"family": "Nguyen", "given": "Dung", "initials": "D"}, {"family": "Laidlaw", "given": "Stephen", "initials": "S"}, {"family": "Hammond", "given": "Edward", "initials": "E"}, {"family": "Dredge", "given": "Keith", "initials": "K"}, {"family": "Wilkinson", "given": "Tom M A", "initials": "TMA"}, {"family": "Watterson", "given": "Daniel", "initials": "D"}, {"family": "Khromykh", "given": "Alexander A", "initials": "AA"}, {"family": "Suhrbier", "given": "Andreas", "initials": "A"}, {"family": "Carroll", "given": "Miles W", "initials": "MW"}, {"family": "Trybala", "given": "Edward", "initials": "E"}, {"family": "Bergstr\u00f6m", "given": "Tomas", "initials": "T"}, {"family": "Ferro", "given": "Vito", "initials": "V", "orcid": "0000-0003-3306-2550", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/059cdf96e0114bb4ab46289d10956055.json"}}, {"family": "Skidmore", "given": "Mark A", "initials": "MA"}, {"family": "Turnbull", "given": "Jeremy E", "initials": "JE", "orcid": "0000-0002-1791-754X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/066f42660595487e817530f8888ee45a.json"}}], "type": "journal article", "published": "2022-05-25", "journal": {"title": "ACS Cent Sci", "issn": "2374-7943", "volume": "8", "issue": "5", "pages": "527-545", "issn-l": null}, "abstract": "Heparan sulfate (HS) is a cell surface polysaccharide recently identified as a coreceptor with the ACE2 protein for the S1 spike protein on SARS-CoV-2 virus, providing a tractable new therapeutic target. Clinically used heparins demonstrate an inhibitory activity but have an anticoagulant activity and are supply-limited, necessitating alternative solutions. Here, we show that synthetic HS mimetic pixatimod (PG545), a cancer drug candidate, binds and destabilizes the SARS-CoV-2 spike protein receptor binding domain and directly inhibits its binding to ACE2, consistent with molecular modeling identification of multiple molecular contacts and overlapping pixatimod and ACE2 binding sites. Assays with multiple clinical isolates of SARS-CoV-2 virus show that pixatimod potently inhibits the infection of monkey Vero E6 cells and physiologically relevant human bronchial epithelial cells at safe therapeutic concentrations. Pixatimod also retained broad potency against variants of concern (VOC) including B.1.1.7 (Alpha), B.1.351 (Beta), B.1.617.2 (Delta), and B.1.1.529 (Omicron). Furthermore, in a K18-hACE2 mouse model, pixatimod significantly reduced SARS-CoV-2 viral titers in the upper respiratory tract and virus-induced weight loss. This demonstration of potent anti-SARS-CoV-2 activity tolerant to emerging mutations establishes proof-of-concept for targeting the HS-Spike protein-ACE2 axis with synthetic HS mimetics and provides a strong rationale for clinical investigation of pixatimod as a potential multimodal therapeutic for COVID-19.", "doi": "10.1021/acscentsci.1c01293", "pmid": "35647275", "labels": {"Category: Biochemistry": null, "Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9136977"}], "notes": [], "created": "2022-06-21T17:31:54.664Z", "modified": "2023-06-19T14:56:08.925Z"}, {"entity": "publication", "iuid": "456dc8ed53b644328aedc39158d52624", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/456dc8ed53b644328aedc39158d52624.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/456dc8ed53b644328aedc39158d52624"}}, "title": "Prior-aware autoencoders for lung pathology segmentation.", "authors": [{"family": "Astaraki", "given": "Mehdi", "initials": "M"}, {"family": "Smedby", "given": "\u00d6rjan", "initials": "\u00d6"}, {"family": "Wang", "given": "Chunliang", "initials": "C"}], "type": "journal article", "published": "2022-05-25", "journal": {"title": "Med Image Anal", "issn": "1361-8423", "volume": "80", "pages": "102491", "issn-l": null}, "abstract": "Segmentation of lung pathology in Computed Tomography (CT) images is of great importance for lung disease screening. However, the presence of different types of lung pathologies with a wide range of heterogeneities in size, shape, location, and texture, on one side, and their visual similarity with respect to surrounding tissues, on the other side, make it challenging to perform reliable automatic lesion segmentation. To leverage segmentation performance, we propose a deep learning framework comprising a Normal Appearance Autoencoder (NAA) model to learn the distribution of healthy lung regions and reconstruct pathology-free images from the corresponding pathological inputs by replacing the pathological regions with the characteristics of healthy tissues. Detected regions that represent prior information regarding the shape and location of pathologies are then integrated into a segmentation network to guide the attention of the model into more meaningful delineations. The proposed pipeline was tested on three types of lung pathologies, including pulmonary nodules, Non-Small Cell Lung Cancer (NSCLC), and Covid-19 lesion on five comprehensive datasets. The results show the superiority of the proposed prior model, which outperformed the baseline segmentation models in all the cases with significant margins. On average, adding the prior model improved the Dice coefficient for the segmentation of lung nodules by 0.038, NSCLCs by 0.101, and Covid-19 lesions by 0.041. We conclude that the proposed NAA model produces reliable prior knowledge regarding the lung pathologies, and integrating such knowledge into a prior segmentation network leads to more accurate delineations.", "doi": "10.1016/j.media.2022.102491", "pmid": "35653902", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1361-8415(22)00138-4"}], "notes": [], "created": "2022-06-21T17:21:31.741Z", "modified": "2022-06-21T17:21:46.880Z"}, {"entity": "publication", "iuid": "754359aeb3274887b4ed42654c5cb5a7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/754359aeb3274887b4ed42654c5cb5a7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/754359aeb3274887b4ed42654c5cb5a7"}}, "title": "COVID-19 seroprevalence and clinical picture in Swedish pediatric oncology and hematology patients.", "authors": [{"family": "Sundberg", "given": "Emil", "initials": "E", "orcid": "0000-0001-5087-1400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62ac6304201e4ec181ea55bcadd16b0d.json"}}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Nilsson", "given": "Anna", "initials": "A", "orcid": "0000-0001-5885-7101", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e552225ab82346d1b2d727584683f156.json"}}, {"family": "Pahnke", "given": "Simon", "initials": "S"}, {"family": "Enblad", "given": "Gunilla", "initials": "G"}, {"family": "Kolstad", "given": "Linda", "initials": "L"}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Torkki", "given": "Milla", "initials": "M"}, {"family": "Zhou", "given": "Otto", "initials": "O"}, {"family": "Anderson", "given": "Jenna", "initials": "J"}, {"family": "Harila-Saari", "given": "Arja", "initials": "A", "orcid": "0000-0003-2767-5828", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61332c8f7db64f4e81a61f3b68439025.json"}}, {"family": "Palle", "given": "Josefine", "initials": "J"}], "type": "journal article", "published": "2022-05-25", "journal": {"title": "Pediatr Blood Cancer", "issn": "1545-5017", "pages": "e29773", "issn-l": null}, "abstract": "Children develop symptomatic coronavirus disease 2019 (COVID-19) more rarely than adults upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pediatric oncology and hematology patients may be at increased risk of severe COVID-19 due to their underlying disease or treatment. We investigated COVID-19 and seroprevalence of anti-SARS-CoV-2 antibodies, respectively, in a Swedish cohort of pediatric oncology and hematology patients.\n\nPatients (n = 136) were recruited between June 2020 and September 2021 at Uppsala University Children's Hospital, Sweden. Up to six consecutive blood samples per patient were analyzed for wild-type anti-S1 IgM and IgG antibodies (including after vaccination, n = 4). Clinical data on COVID-19 (including polymerase chain reaction [PCR] test results) were collected from electronic medical records. A questionnaire was completed at recruitment.\n\nA cumulative seroprevalence (IgM and IgG) of 33% (45/136 patients, 95% confidence interval: 25%-41%) was observed in this patient cohort, of whom 66% (90/136 patients) were under severe immunosuppressive treatment during the study period. Increasing patient age (p = .037) and PCR test results (p < .002) were associated with seropositivity in nonvaccinated cases. Most seropositive, nonvaccinated cases (32/43, 74%) were never PCR-verified for SARS-CoV-2 infection. Of the 13 patients with PCR-verified infection, nine (69%) reported mild disease. A majority (63%) reported continued school attendance during the pandemic.\n\nSwedish pediatric oncology and hematology patients developed antibodies against SARS-CoV-2, despite their diagnosis and/or treatment, and the observed seroprevalence was similar to that in national pediatric outpatients. PCR-verified cases underestimate the true incidence of COVID-19 in this patient cohort.", "doi": "10.1002/pbc.29773", "pmid": "35615775", "labels": {"Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Research Area: Pandemic preparedness": null, "Type: Journal article": null, "Category: Health": null, "Research Area: Drug discovery and repurposing of drugs": null}, "xrefs": [], "notes": [], "created": "2022-06-21T17:48:12.392Z", "modified": "2022-06-21T17:49:07.415Z"}, {"entity": "publication", "iuid": "737f9cdb4b82484db6b5c7f3e581bb86", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/737f9cdb4b82484db6b5c7f3e581bb86.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/737f9cdb4b82484db6b5c7f3e581bb86"}}, "title": "Assessing Access to WASH in Urban Schools during COVID-19 in Kazakhstan: Case Study of Central Kazakhstan.", "authors": [{"family": "Toleubekov", "given": "Berik", "initials": "B", "orcid": "0000-0003-2156-5513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de10dab596684ac6b713795af6a862d6.json"}}, {"family": "Bolatova", "given": "Zhanerke", "initials": "Z"}, {"family": "Stafstr\u00f6m", "given": "Martin", "initials": "M", "orcid": "0000-0002-6392-3588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/875e62bf093942a990203d3e4dd20d70.json"}}], "type": "journal article", "published": "2022-05-25", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "11", "issn-l": null}, "abstract": "The WHO/UNICEF Joint Monitoring Program (JMP) for Water Supply, Sanitation and Hygiene (WASH) produces global estimates of the real situation of access to water, sanitation and hygiene services, and sanitation and hygiene in households, educational institutes and health care facilities; however it is lacking data on schools in Kazakhstan. Thus, the aim of this research was to assess access to WASH in schools of urban area in Kazakhstan. The study was conducted in seven schools of Central Kazakhstan during the COVID-19 pandemic and restrictive measures. Three data collection methods were used: a questionnaire for administrative staff, a questionnaire for parents and observation. Parents of offline study pupils (only second and third grades due to the pandemic) were included in the survey. Students had access to in-building toilets in all schools connected to the centralized sewer. The number of school toilets varied from 7 (KAZ200085) to 61 (KAZ200089). The average amount of toilets was 28.08 \u00b1 16.97. Only two out of seven schools complied with the requirements of Kazakhstan national sanitary standards for the ratio of school toilets to the number of students. From the questionnaire with the school administrations, it was defined that the primary source of drinking water was the public water supply. All schools regularly disinfect and check the water supply system. At the same time, the results also revealed discrepancies in the answers between administration and parents (2.6% of parents showed that their children have rare access to drinking water), and insufficient monitoring of implementation of WASH services. This study also confirmed that the full provision of access to water and water services in the structure of educational institutions solves several SDG targets.", "doi": "10.3390/ijerph19116438", "pmid": "35682022", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19116438"}], "notes": [], "created": "2022-06-20T19:27:40.112Z", "modified": "2022-06-20T19:27:40.249Z"}, {"entity": "publication", "iuid": "cdf1dc4e16d74a99bdbc48ee13abcea5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cdf1dc4e16d74a99bdbc48ee13abcea5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cdf1dc4e16d74a99bdbc48ee13abcea5"}}, "title": "Amyloidogenesis of SARS-CoV-2 Spike Protein.", "authors": [{"family": "Nystr\u00f6m", "given": "Sofie", "initials": "S", "orcid": "0000-0002-4303-4783", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7996ddca29dc4632a0a37327ad0388b4.json"}}, {"family": "Hammarstr\u00f6m", "given": "Per", "initials": "P", "orcid": "0000-0001-5827-3587", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b57ea4fc5c2842628fe34bb8cda78889.json"}}], "type": "journal article", "published": "2022-05-25", "journal": {"title": "J Am Chem Soc", "issn": "1520-5126", "volume": "144", "issue": "20", "pages": "8945-8950", "issn-l": null}, "abstract": "SARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances together with neurologic and cardiac problems led us to investigate the amyloidogenicity of the SARS-CoV-2 spike protein (S-protein). Amyloid fibril assays of peptide library mixtures and theoretical predictions identified seven amyloidogenic sequences within the S-protein. All seven peptides in isolation formed aggregates during incubation at 37 \u00b0C. Three 20-amino acid long synthetic spike peptides (sequence 192-211, 601-620, 1166-1185) fulfilled three amyloid fibril criteria: nucleation dependent polymerization kinetics by ThT, Congo red positivity, and ultrastructural fibrillar morphology. Full-length folded S-protein did not form amyloid fibrils, but amyloid-like fibrils with evident branching were formed during 24 h of S-protein coincubation with the protease neutrophil elastase (NE) in vitro. NE efficiently cleaved S-protein, rendering exposure of amyloidogenic segments and accumulation of the amyloidogenic peptide 194-203, part of the most amyloidogenic synthetic spike peptide. NE is overexpressed at inflamed sites of viral infection. Our data propose a molecular mechanism for potential amyloidogenesis of SARS-CoV-2 S-protein in humans facilitated by endoproteolysis. The prospective of S-protein amyloidogenesis in COVID-19 disease associated pathogenesis can be important in understanding the disease and long COVID-19.", "doi": "10.1021/jacs.2c03925", "pmid": "35579205", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T18:04:57.349Z", "modified": "2022-06-21T18:04:57.462Z"}, {"entity": "publication", "iuid": "76e6763d7f8044789c7df8692fde2bd3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76e6763d7f8044789c7df8692fde2bd3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76e6763d7f8044789c7df8692fde2bd3"}}, "title": "Venerable vulnerability or remarkable resilience? A prospective study of the impact of the first wave of the COVID-19 pandemic and quarantine measures on loneliness in Swedish older adults with home care.", "authors": [{"family": "Gustafsson", "given": "Per E", "initials": "PE", "orcid": "0000-0002-3972-5362", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9ac282ae534432f9e8135a8070683bc.json"}}, {"family": "Nilsson", "given": "Ingeborg", "initials": "I"}, {"family": "San Sebastian", "given": "Miguel", "initials": "M"}], "type": "journal article", "published": "2022-05-24", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "5", "pages": "e060209", "issn-l": "2044-6055"}, "abstract": "To examine the early impact of the pandemic and of quarantine measures targeting older adults introduced in March 2020 on loneliness among older adults in Sweden.Design Prospective pretest-posttest and controlled interrupted time series designs.\n\nThe population of older adults receiving home care before and during the emergence of the first COVID-19 pandemic wave in Sweden in Spring 2020.\n\nRespondents (n=45 123, mean age 85.6 years, 67.6% women) came from two waves of a total population survey targeting all community-dwelling older adults receiving home care for older adults in Sweden in Spring 2019 and 2020.\n\nSelf-reported loneliness.\n\nResults estimated 14% (95% CI: 10 to 19) higher loneliness in Spring 2020 compared with 2019, taking covariates into account. No impact of the quarantine measure was found (1% increase, 95% CI: -1 to 4).\n\nThe results illustrate the broader public health consequences of the COVID-19 pandemic for older adults, but also suggest a relative resilience among older adults in home care to quarantine measures, at least during the first months of the pandemic. Future studies should examine the long-term effects of sustained pandemic and social distancing measures on loneliness among older adults.", "doi": "10.1136/bmjopen-2021-060209", "pmid": "35613816", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-060209"}], "notes": [], "created": "2022-06-21T17:50:27.186Z", "modified": "2022-06-21T17:50:27.216Z"}, {"entity": "publication", "iuid": "0c4f666e5c354548a2cfcebd30d440c3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c4f666e5c354548a2cfcebd30d440c3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c4f666e5c354548a2cfcebd30d440c3"}}, "title": "Antimicrobial use in Sweden during the COVID-19 pandemic: prescription fill and inpatient care requisition patterns.", "authors": [{"family": "Nakitanda", "given": "Aya Olivia", "initials": "AO"}, {"family": "Karlsson", "given": "P\u00e4r", "initials": "P"}, {"family": "L\u00f6fling", "given": "Lukas", "initials": "L"}, {"family": "Cesta", "given": "Carolyn E", "initials": "CE"}, {"family": "Odsbu", "given": "Ingvild", "initials": "I"}], "type": "journal article", "published": "2022-05-24", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "volume": "22", "issue": "1", "pages": "492", "issn-l": null}, "abstract": "Increased and inappropriate antimicrobial use are the key drivers of the emergence of antimicrobial resistance, and there have been widespread concerns around potential antimicrobial misuse, overuse and their consequences during the COVID-19 pandemic. To better understand the impact of the pandemic on antimicrobial use, particularly in light of the resurgence of COVID-19 cases since the summer of 2020, we assessed trends in antimicrobial prescription fills and hospital requisitions in Sweden during 2020 against those of preceding years.\n\nWe performed a descriptive study using population-based data from the Swedish Prescribed Drug Register and the Swedish e-Health Agency. The weekly number of prescriptions filled and the total volume sold to inpatient care institutions in defined daily doses (DDDs) per 1000 inhabitants for systemic antibacterials (Anatomical Therapeutic Chemical therapeutic subgroup J01 excluding J01XX), antimycotics (J02), antivirals (J05) and antiprotozoals (P01) were computed and evaluated from time series graphs. A time series linear regression with ordinary least squares (OLS) estimation was used to model 2015-2019 data and predict the expected number of prescriptions filled and volumes sold in DDDs per 1000 inhabitants during 2020 with 95% confidence limits.\n\nFrom mid-March 2020, the weekly rate of antibiotic and antiprotozoal prescriptions filled plummeted to unprecedentedly low levels for the rest of the year; while unprecedentedly high numbers of antiviral prescriptions were filled weekly between mid-February and mid-March 2020. There was a net reduction in annual dispensing of antibiotics by 17%; of antiprotozoals by 21%; and of antivirals by 0.3% during 2020 compared to 2019. Inpatient care requisitions of antiprotozoals and antibiotics surged to 6-year highs during March 2020, resulting in a 127% increase in DDDs of antiprotozoals sold from 2019. The volume of antibiotics and antivirals sold to inpatient care institutions in 2020 decreased by 3% and 13% compared to 2019, respectively.\n\nThe overall decline in antimicrobial prescriptions filled in Sweden during 2020 were in part, collateral dividends of the COVID-19 pandemic.", "doi": "10.1186/s12879-022-07405-3", "pmid": "35610597", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC9128331"}, {"db": "pii", "key": "10.1186/s12879-022-07405-3"}], "notes": [], "created": "2023-01-13T13:37:43.906Z", "modified": "2023-01-13T13:37:43.909Z"}, {"entity": "publication", "iuid": "385d9bb6a0ce4897a3dc84dce0af7a1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/385d9bb6a0ce4897a3dc84dce0af7a1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/385d9bb6a0ce4897a3dc84dce0af7a1d"}}, "title": "Editorial: The Consequences of COVID-19 on the Mental Well-Being of Parents, Children and Adolescents.", "authors": [{"family": "Sorbring", "given": "Emma", "initials": "E"}, {"family": "Svensson", "given": "Ylva", "initials": "Y"}, {"family": "Erlandsson", "given": "Soly I", "initials": "SI"}, {"family": "Deater-Deckard", "given": "Kirby", "initials": "K"}], "type": "editorial", "published": "2022-05-23", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "13", "pages": "924599", "issn-l": "1664-0640"}, "abstract": null, "doi": "10.3389/fpsyt.2022.924599", "pmid": "35677874", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC9168802"}], "notes": [], "created": "2022-06-20T19:30:16.042Z", "modified": "2022-06-20T19:30:30.212Z"}, {"entity": "publication", "iuid": "3284070f61ac48e3a02443b00a603a24", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3284070f61ac48e3a02443b00a603a24.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3284070f61ac48e3a02443b00a603a24"}}, "title": "The spoils of war and the long-term spoiling of health conditions of entire nations.", "authors": [{"family": "Navarese", "given": "Eliano P", "initials": "EP"}, {"family": "Grzelakowska", "given": "Klaudyna", "initials": "K"}, {"family": "Mangini", "given": "Francesco", "initials": "F"}, {"family": "Kubica", "given": "Jacek", "initials": "J"}, {"family": "Banach", "given": "Maciej", "initials": "M"}, {"family": "Benn", "given": "Marianne", "initials": "M"}, {"family": "Binder", "given": "Christoph J", "initials": "CJ"}, {"family": "Bor\u00e9n", "given": "Jan", "initials": "J"}, {"family": "Catapano", "given": "Alberico", "initials": "A"}, {"family": "Kronenberg", "given": "Florian", "initials": "F"}, {"family": "Mallat", "given": "Ziad", "initials": "Z"}, {"family": "Moulin", "given": "Philippe", "initials": "P"}, {"family": "\u00d6\u00f6rni", "given": "Katariina", "initials": "K"}, {"family": "Ray", "given": "Kausik K", "initials": "KK"}, {"family": "Roeters van Lennep", "given": "Jeanine E", "initials": "JE"}, {"family": "Romeo", "given": "Stefano", "initials": "S"}, {"family": "Tokgozoglu", "given": "Lale", "initials": "L"}, {"family": "von Eckardstein", "given": "Arnold", "initials": "A"}, {"family": "Zambon", "given": "Alberto", "initials": "A"}, {"family": "Raggi", "given": "Paolo", "initials": "P"}], "type": "editorial", "published": "2022-05-21", "journal": {"title": "Atherosclerosis", "issn": "1879-1484", "issn-l": null}, "abstract": "The healthcare system of Ukraine was already suffering from several shortfalls before February 2022, but the war of aggression started by the Russian leadership is poised to inflict a further severe blow that will have long-lasting consequences for the health of all Ukrainians. In pre-war Ukraine, noncommunicable diseases (NCDs) contributed to 91% of deaths, especially cardiovascular diseases (67%). Ukrainians have a high prevalence of risk factors for NCDs ranking among the highest levels reported by the World Health Organization (WHO) in the European (EU) Region. Cardiovascular disease is one of the key health risks for the conflict-affected Ukrainian population due to significant limitations in access to health care and interruptions in the supply of medicines and resources. The excess mortality observed during the COVID-19 pandemic, due to a combination of viral illness and chronic disease states, is bound to increase exponentially from poorly treated NCDs. In this report, we discuss the impact of the war on the public health of Ukraine and potential interventions to provide remote health assistance to the Ukrainian population.", "doi": "10.1016/j.atherosclerosis.2022.05.012", "pmid": "35644760", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0021-9150(22)00248-9"}], "notes": [], "created": "2022-06-21T17:34:06.754Z", "modified": "2022-06-21T17:34:06.790Z"}, {"entity": "publication", "iuid": "53dae477917e4ae38cd3d373c721a178", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53dae477917e4ae38cd3d373c721a178.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53dae477917e4ae38cd3d373c721a178"}}, "title": "Working With Refugees' Health During COVID-19-The Experience of Health- and Social Care Workers in Sweden.", "authors": [{"family": "Mangrio", "given": "Elisabeth", "initials": "E"}, {"family": "Zdravkovic", "given": "Slobodan", "initials": "S"}, {"family": "Strange", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2022-05-19", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "10", "pages": "811974", "issn-l": "2296-2565"}, "abstract": "In Sweden, often seen as one of the most egalitarian countries, the COVID-19 pandemic exposed high levels of health inequality, especially harming people with a refugee background. This is also despite Sweden's image as a refugee-friendly country. In this context, the aim of this paper is to better understand how Swedish health- and social workers have reacted to the health- and social needs of refugees during the pandemic. The Swedish case is particularly interesting because, as seen in the paper, health- and social workers had the task of communicating health guidance to refugees who were sometimes more reliant on information from abroad where the consensus on COVID-19 restrictions ran contrary to the approach recommended by the Swedish public health authority.\n\nThe study utilizes a qualitative content analysis of 13 in-depth interviews with health- and social workers in Sweden, active in the care of refugees within different kinds of health- and social care settings.\n\nThe analysis showed that healthcare services have remained open during the pandemic but with new precautions at reception areas impacting how refugees access healthcare. As discussed in the article, the shift to digital tools has particularly impacted refugees, worsening already existing barriers to healthcare services faced by those with refugee status. Public health recommendations were poorly designed to the needs of refugees whose living conditions often prevented them from self-isolation and social distancing. Furthermore, Sweden's initially non-restrictive approach to the pandemic instructed health- and social-workers to encourage refugees to take far fewer precautions (e.g., self-isolation, home-schooling, pregnant women to avoid virus hotspots) compared both with European neighbors and the international media typically used by refugees. When Sweden shifted toward a more restrictive approach, health- and social-workers had to revise their guidance in relation to the new recommendations around precautions.\n\nRefugees have faced increased barriers to maintaining their health and wellbeing during the pandemic that exceed those experienced by the rest of the Swedish population. Refugees have, in general, taken precautions in regard to social distancing and followed recommendations but faced challenges with social distancing due to isolation and crowded living. Public health authorities have often failed to acknowledge that individuals use increasingly diverse sources of knowledge when trying to protect their health, and that not everyone has access to the knowledge needed to access healthcare and social systems. At the same time, there is a need to acknowledge that refugees are sometimes a source of expertise that was ignored by the Swedish health and social system during the pandemic. There is a need for urgent efforts to halt the worsening health conditions for this specific group, but also to counter knock-on societal effects and rising health inequity.", "doi": "10.3389/fpubh.2022.811974", "pmid": "35669746", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9163396"}], "notes": [], "created": "2022-06-20T19:32:55.131Z", "modified": "2022-06-20T19:33:05.876Z"}, {"entity": "publication", "iuid": "dd82b322ce1f4cccb12ac2f9ebdccd6c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dd82b322ce1f4cccb12ac2f9ebdccd6c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dd82b322ce1f4cccb12ac2f9ebdccd6c"}}, "title": "The association between maternal characteristics and SARS-CoV-2 in pregnancy: a population-based registry study in Sweden and Norway.", "authors": [{"family": "\u00d6rtqvist", "given": "Anne K", "initials": "AK"}, {"family": "Magnus", "given": "Maria C", "initials": "MC"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Oakley", "given": "Laura", "initials": "L"}, {"family": "Nybo Andersen", "given": "Anne-Marie", "initials": "AM"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}], "type": "journal article", "published": "2022-05-19", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "8355", "issn-l": "2045-2322"}, "abstract": "The objectives of the current study were to identify risk factors for SARS-CoV-2 positivity, and to address how different testing strategies, choice of comparison group, and population background characteristics may influence observed associations. National registries data for 107,627 pregnant women in Sweden and 81,195 in Norway, were used to identify risk factors for SARS-CoV-2, separately for women under non-universal testing (testing by indication) and universal testing (testing of all pregnant women in contact with a delivery ward). We also investigated underlying characteristics associated with testing for SARS-CoV-2. Overall, 2.1% of pregnant women in Sweden and 1.1% in Norway were test-positive during the pandemic's first 18 months. We show that the choice of test strategy for SARS-CoV-2 provided different associations with risk factors for the disease; for instance, women who were overweight, obese or had gestational diabetes had increased odds of being test-positive under non-universal testing, but not under universal testing. Nevertheless, a consistent pattern of association between being born in the Middle East and Africa and test-positivity was found independent of test strategy and in both countries. These women were also less likely to get tested. Our results are useful to consider for surveillance and clinical recommendations for pregnant women during the current and future pandemics.", "doi": "10.1038/s41598-022-12395-y", "pmid": "35589871", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-12395-y"}, {"db": "pmc", "key": "PMC9120467"}], "notes": [], "created": "2022-06-21T18:00:33.000Z", "modified": "2022-06-21T18:00:44.440Z"}, {"entity": "publication", "iuid": "abc068b1ea5d4b08bad47d5041ef7217", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abc068b1ea5d4b08bad47d5041ef7217.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abc068b1ea5d4b08bad47d5041ef7217"}}, "title": "SARS-CoV-2 airway reactivity in children: more of the same?", "authors": [{"family": "Karlsson", "given": "J", "initials": "J", "orcid": "0000-0003-2277-0092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a428771f0dc41948d1d1e13131497bc.json"}}, {"family": "Johansen", "given": "M", "initials": "M"}, {"family": "Engelhardt", "given": "T", "initials": "T"}], "type": "editorial", "published": "2022-05-19", "journal": {"title": "Anaesthesia", "issn": "1365-2044", "issn-l": "0003-2409"}, "abstract": null, "doi": "10.1111/anae.15760", "pmid": "35587812", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T18:01:57.625Z", "modified": "2022-06-21T18:01:57.680Z"}, {"entity": "publication", "iuid": "298d8af4f737432192eebe7e304e2165", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/298d8af4f737432192eebe7e304e2165.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/298d8af4f737432192eebe7e304e2165"}}, "title": "Pandemic responses at the subnational level: Exploring politics, administration, and politicization in Swedish municipalities.", "authors": [{"family": "Sparf", "given": "J\u00f6rgen", "initials": "J", "orcid": "0000-0002-0202-0609", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01828d7aea6742b1a425f44c5c0665cf.json"}}, {"family": "Petridou", "given": "Evangelia", "initials": "E", "orcid": "0000-0001-7316-4899", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21de455914874bdf8fbaf544e51053b0.json"}}, {"family": "Granberg", "given": "Mikael", "initials": "M", "orcid": "0000-0002-5356-4112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee3d0f0c22c749b8ac5ac2f2e09dc4b4.json"}}, {"family": "Becker", "given": "Per", "initials": "P", "orcid": "0000-0001-9379-9461", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b55e9fcbd1c44de2b8c10a5bad30888b.json"}}, {"family": "Onn", "given": "Beatrice", "initials": "B"}], "type": "journal article", "published": "2022-05-19", "journal": {"title": "Eur Policy Anal", "issn": "2380-6567", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The Swedish response to the pandemic at the national level has attracted considerable international attention, but little focus has been placed on the way municipalities dealt with the crisis. Using Hay's dimensions of politicization, namely the capacity for human agency, deliberation in the public domain, and social context, we analyze the politicization of the municipal response to the pandemic in Sweden. We do this based on the analysis of the decision making process to activate (or not) an extraordinary crisis management committee. We find inter alia, that (i) only a quarter of the municipalities activated the committee while a majority of them had an alternate special organization in place; (ii) support to the existing organizational structure was more salient than creating an extraordinary organization, and (iii) a robust municipal structure was deemed to be one able to withstand shocks without resorting to extraordinary governance arrangements. We find a 'conditioned politicization' of the response, privileging administration over politics.", "doi": "10.1002/epa2.1151", "pmid": "35942065", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "EPA21151"}, {"db": "pmc", "key": "PMC9347882"}], "notes": [], "created": "2022-08-11T11:50:43.127Z", "modified": "2022-11-09T08:42:43.355Z"}, {"entity": "publication", "iuid": "2e39de17d4d34be682f9d98fa9e2c57b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e39de17d4d34be682f9d98fa9e2c57b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e39de17d4d34be682f9d98fa9e2c57b"}}, "title": "Pandemic impact on patients with advanced non-COVID-19 illness and their family carers receiving specialised palliative home care: a qualitative study.", "authors": [{"family": "Nyblom", "given": "Stina", "initials": "S", "orcid": "0000-0002-4998-0324", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9037f37fbb29422dab6a2a59a8d74a85.json"}}, {"family": "Benkel", "given": "Inger", "initials": "I"}, {"family": "Carling", "given": "Linn\u00e9a", "initials": "L"}, {"family": "L\u00f6fdahl", "given": "Elisabet", "initials": "E"}, {"family": "Molander", "given": "Ulla", "initials": "U"}, {"family": "\u00d6hl\u00e9n", "given": "Joakim", "initials": "J"}], "type": "journal article", "published": "2022-05-19", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "5", "pages": "e059577", "issn-l": "2044-6055"}, "abstract": "To investigate the experiential impact of the COVID-19 pandemic on patients with non-COVID, life-threatening disease and their family carers.\n\nAn interpretative qualitative design informed by phenomenological hermeneutics and based on data from in-depth interviews, performed between June and September 2020.\n\nPatients receiving specialised palliative home care and their family carers living in Sweden.\n\n22 patients (male/female 11/11) and 17 carers (male/female 5/12) aged 50 years and older. All the patients received specialised palliative home care and most were diagnosed with cancer.\n\naged 18 years or older, diagnosed with an incurable life-threatening, non-COVID disease, sufficient strength to participate and capacity to provide informed consent. Participants were selected through a combination of convenient and consecutive sampling.\n\nThe significance of the pandemic for both patients and carers showed a continuum from being minimally affected in comparison to the severe underlying disease to living in isolation with constant fear of becoming infected and falling ill with COVID-19, which some likened to torture.The imposed restrictions on social contact due to the pandemic were particularly palpable for this group of people with a non-COVID-19, life-limiting condition, as it was said to steal valuable moments of time that had already been measured.Most patients and carers found access to specialised palliative home care was maintained despite the pandemic. This care was of paramount importance for their sense of security and was often their sole visiting social contact.\n\nIn the pandemic situation, highly accessible support from healthcare and social care at home is particularly important to create security for both patients and carers. Thus, to provide appropriate support, it is important for healthcare and social care personnel to be aware of the great diversity of reactions patients in palliative care and their carers may have to a pandemic threat.", "doi": "10.1136/bmjopen-2021-059577", "pmid": "35589359", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-059577"}, {"db": "pmc", "key": "PMC9121113"}], "notes": [], "created": "2022-06-21T18:00:58.929Z", "modified": "2022-06-21T18:00:58.991Z"}, {"entity": "publication", "iuid": "6b86554ba821470f8ff9bbc8e29a8a0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b86554ba821470f8ff9bbc8e29a8a0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b86554ba821470f8ff9bbc8e29a8a0e"}}, "title": "Optimal Drug Regimen and Combined Drug Therapy and Its Efficacy in the Treatment of COVID-19: A Within-Host Modeling Study.", "authors": [{"family": "Chhetri", "given": "Bishal", "initials": "B"}, {"family": "Bhagat", "given": "Vijay M", "initials": "VM"}, {"family": "Vamsi", "given": "D K K", "initials": "DKK", "orcid": "0000-0002-1296-0135", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea3460b1791047619e40a7b1af74e040.json"}}, {"family": "Ananth", "given": "V S", "initials": "VS"}, {"family": "Prakash", "given": "Bhanu", "initials": "B"}, {"family": "Muthusamy", "given": "Swapna", "initials": "S"}, {"family": "Deshmukh", "given": "Pradeep", "initials": "P"}, {"family": "Sanjeevi", "given": "Carani B", "initials": "CB"}], "type": "journal article", "published": "2022-05-19", "journal": {"title": "Acta Biotheor", "issn": "1572-8358", "volume": "70", "issue": "2", "pages": "16", "issn-l": null}, "abstract": "The COVID-19 pandemic has resulted in more than 524 million cases and 6 million deaths worldwide. Various drug interventions targeting multiple stages of COVID-19 pathogenesis can significantly reduce infection-related mortality. The current within-host mathematical modeling study addresses the optimal drug regimen and efficacy of combination therapies in the treatment of COVID-19. The drugs/interventions considered include Arbidol, Remdesivir, Interferon (INF) and Lopinavir/Ritonavir. It is concluded that these drugs, when administered singly or in combination, reduce the number of infected cells and viral load. Four scenarios dealing with the administration of a single drug, two drugs, three drugs and all four are discussed. In all these scenarios, the optimal drug regimen is proposed based on two methods. In the first method, these medical interventions are modeled as control interventions and a corresponding objective function and optimal control problem are formulated. In this framework, the optimal drug regimen is derived. Later, using the comparative effectiveness method, the optimal drug regimen is derived based on the basic reproduction number and viral load. The average number of infected cells and viral load decreased the most when all four drugs were used together. On the other hand, the average number of susceptible cells decreased the most when Arbidol was administered alone. The basic reproduction number and viral load decreased the most when all four interventions were used together, confirming the previously obtained finding of the optimal control problem. The results of this study can help physicians make decisions about the treatment of the life-threatening COVID-19 infection.", "doi": "10.1007/s10441-022-09440-8", "pmid": "35588019", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10441-022-09440-8"}, {"db": "pmc", "key": "PMC9118007"}], "notes": [], "created": "2022-06-21T18:01:41.810Z", "modified": "2022-06-21T18:01:43.241Z"}, {"entity": "publication", "iuid": "bb58767a28484d2fbd148fb1a9341e6d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb58767a28484d2fbd148fb1a9341e6d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb58767a28484d2fbd148fb1a9341e6d"}}, "title": "TTCOV19: timing of tracheotomy in SARS-CoV-2-infected patients: a multicentre, single-blinded, randomized, controlled trial.", "authors": [{"family": "Eeg-Olofsson", "given": "M\u00e5ns", "initials": "M"}, {"family": "Pauli", "given": "Nina", "initials": "N"}, {"family": "Hafsten", "given": "Louise", "initials": "L"}, {"family": "Jacobsson", "given": "Josephine", "initials": "J"}, {"family": "Lundborg", "given": "Christopher", "initials": "C"}, {"family": "Brink", "given": "Magnus", "initials": "M"}, {"family": "Larsson", "given": "Helen", "initials": "H"}, {"family": "Lindell", "given": "Ellen", "initials": "E"}, {"family": "L\u00f6whagen", "given": "Karin", "initials": "K"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Bergquist", "given": "Henrik", "initials": "H"}], "type": "journal article", "published": "2022-05-18", "journal": {"title": "Crit Care", "issn": "1466-609X", "volume": "26", "issue": "1", "pages": "142", "issn-l": "1364-8535"}, "abstract": "Critically ill COVID-19 patients may develop acute respiratory distress syndrome and the need for respiratory support, including mechanical ventilation in the intensive care unit. Previous observational studies have suggested early tracheotomy to be advantageous. The aim of this parallel, multicentre, single-blinded, randomized controlled trial was to evaluate the optimal timing of tracheotomy.\n\nSARS-CoV-2-infected patients within the Region V\u00e4stra G\u00f6taland of Sweden who needed intubation and mechanical respiratory support were included and randomly assigned to early tracheotomy (\u2264 7 days after intubation) or late tracheotomy (\u2265 10 days after intubation). The primary objective was to compare the total number of mechanical ventilation days between the groups.\n\nOne hundred fifty patients (mean age 65 years, 79% males) were included. Seventy-two patients were assigned to early tracheotomy, and 78 were assigned to late tracheotomy. One hundred two patients (68%) underwent tracheotomy of whom sixty-one underwent tracheotomy according to the protocol. The overall median number of days in mechanical ventilation was 18 (IQR 9; 28), but no significant difference was found between the two treatment regimens in the intention-to-treat analysis (between-group difference: - 1.5 days (95% CI - 5.7 to 2.8); p = 0.5). A significantly reduced number of mechanical ventilation days was found in the early tracheotomy group during the per-protocol analysis (between-group difference: - 8.0 days (95% CI - 13.8 to - 2.27); p = 0.0064). The overall correlation between the timing of tracheotomy and days of mechanical ventilation was significant (Spearman's correlation: 0.39, p < 0.0001). The total death rate during intensive care was 32.7%, but no significant differences were found between the groups regarding survival, complications or adverse events.\n\nThe potential superiority of early tracheotomy when compared to late tracheotomy in critically ill patients with COVID-19 was not confirmed by the present randomized controlled trial but is a strategy that should be considered in selected cases where the need for MV for more than 14 days cannot be ruled out. Trial registration NCT04412356 , registered 05/24/2020.", "doi": "10.1186/s13054-022-04005-0", "pmid": "35585614", "labels": {"Category: Biochemistry": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-022-04005-0"}, {"db": "pmc", "key": "PMC9115544"}, {"db": "ClinicalTrials.gov", "key": "NCT04412356"}], "notes": [], "created": "2022-06-21T18:02:19.433Z", "modified": "2022-06-21T18:02:19.446Z"}, {"entity": "publication", "iuid": "bf86788503da4c2a9f9fbc540cb775a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf86788503da4c2a9f9fbc540cb775a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf86788503da4c2a9f9fbc540cb775a0"}}, "title": "Impacts of COVID-19 on people and sea: marine social science imaginations.", "authors": [{"family": "Knutsson", "given": "Per", "initials": "P"}, {"family": "Bavinck", "given": "Maarten", "initials": "M"}], "type": "journal article", "published": "2022-05-18", "journal": {"title": "Marit Stud", "issn": "2212-9790", "issn-l": null, "volume": "21", "issue": "2", "pages": "155-158"}, "abstract": null, "doi": "10.1007/s40152-022-00270-5", "pmid": "35601845", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "270"}, {"db": "pmc", "key": "PMC9114292"}], "notes": [], "created": "2022-06-21T17:56:05.333Z", "modified": "2022-11-22T05:37:52.688Z"}, {"entity": "publication", "iuid": "1b2b7251165d4c37a0d4ec7f404f552a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b2b7251165d4c37a0d4ec7f404f552a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b2b7251165d4c37a0d4ec7f404f552a"}}, "title": "Explaining the complex impact of the Covid-19 pandemic on children with overweight and obesity: a comparative ecological analysis of parents' perceptions in three countries.", "authors": [{"family": "Nowicka", "given": "P", "initials": "P"}, {"family": "Ek", "given": "A", "initials": "A"}, {"family": "Jurca-Simina", "given": "I E", "initials": "IE"}, {"family": "Bouzas", "given": "C", "initials": "C"}, {"family": "Argelich", "given": "E", "initials": "E"}, {"family": "Nordin", "given": "K", "initials": "K"}, {"family": "Garc\u00eda", "given": "S", "initials": "S"}, {"family": "Vasquez Barquero", "given": "M Y", "initials": "MY"}, {"family": "Hoffer", "given": "U", "initials": "U"}, {"family": "Reijs Richards", "given": "H", "initials": "H"}, {"family": "Tur", "given": "J A", "initials": "JA"}, {"family": "Chirita-Emandi", "given": "A", "initials": "A"}, {"family": "Eli", "given": "K", "initials": "K"}], "type": "journal article", "published": "2022-05-17", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "1000", "issn-l": null}, "abstract": "The Covid-19 pandemic has changed children's eating and physical activity behaviours. These changes have been positive for some households and negative for others, revealing health inequalities that have ramifications for childhood obesity. This study investigates the pandemic's impact on families of children aged 2-6 years with overweight or obesity.\n\nDrawing on interviews conducted as part of a randomised controlled trial (RCT) for childhood obesity, thematic analysis was used to examine how parents of pre-schoolers perceived changes in their eating, screentime and physical activity behaviours between the first and second waves of Covid-19. Parents (n = 70, representing 68 families) were interviewed twice during a period of 6 months in three countries with markedly different pandemic policies - Sweden, Romania, and Spain. The analysis is informed by Bronfenbrenner's ecological systems theory, which embeds home- and school-based influences within societal and policy contexts.\n\nThe findings show that, although all participants were recruited from an RCT for families of children with excess weight, they reported different responses to the pandemic's second wave, with some children engaging in healthier eating and physical activity, and others engaging in comfort eating and a more sedentary lifestyle. Differences in children's obesity-related behaviours were closely related to differences in parents' practices, which were, in turn, linked to their emotional and social wellbeing. Notably, across all sites, parents' feeding and physical activity facilitation practices, as well as their emotional and social wellbeing, were embedded in household resilience. In resilient households, where parents had secure housing and employment, they were better able to adapt to the challenges posed by the pandemic, whereas parents who experienced household insecurity found it more difficult to cope.\n\nAs the Covid-19 pandemic is turning into a long-term public health challenge, studies that address household resilience are crucial for developing effective prevention and treatment responses to childhood obesity.", "doi": "10.1186/s12889-022-13351-1", "pmid": "35581642", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-022-13351-1"}, {"db": "pmc", "key": "PMC9113066"}], "notes": [], "created": "2022-06-21T18:04:35.017Z", "modified": "2022-06-21T18:04:35.030Z"}, {"entity": "publication", "iuid": "8db5b4dcddc6416aafb66df37925e9b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8db5b4dcddc6416aafb66df37925e9b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8db5b4dcddc6416aafb66df37925e9b1"}}, "title": "Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm.", "authors": [{"family": "Yang", "given": "Huan", "initials": "H", "orcid": "0000-0001-8796-5523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c22b8c5acc94b878afde7fc4e39c378.json"}}, {"family": "George", "given": "Sam J", "initials": "SJ"}, {"family": "Thompson", "given": "Dane A", "initials": "DA"}, {"family": "Silverman", "given": "Harold A", "initials": "HA"}, {"family": "Tsaava", "given": "T\u00e9a", "initials": "T"}, {"family": "Tynan", "given": "Aisling", "initials": "A"}, {"family": "Pavlov", "given": "Valentin A", "initials": "VA"}, {"family": "Chang", "given": "Eric H", "initials": "EH"}, {"family": "Andersson", "given": "Ulf", "initials": "U"}, {"family": "Brines", "given": "Michael", "initials": "M"}, {"family": "Chavan", "given": "Sangeeta S", "initials": "SS"}, {"family": "Tracey", "given": "Kevin J", "initials": "KJ"}], "type": "journal article", "published": "2022-05-16", "journal": {"title": "Mol Med", "issn": "1528-3658", "volume": "28", "issue": "1", "pages": "57", "issn-l": "1076-1551"}, "abstract": "Severe COVID-19 is characterized by pro-inflammatory cytokine release syndrome (cytokine storm) which causes high morbidity and mortality. Recent observational and clinical studies suggest famotidine, a histamine 2 receptor (H2R) antagonist widely used to treat gastroesophageal reflux disease, attenuates the clinical course of COVID-19. Because evidence is lacking for a direct antiviral activity of famotidine, a proposed mechanism of action is blocking the effects of histamine released by mast cells. Here we hypothesized that famotidine activates the inflammatory reflex, a brain-integrated vagus nerve mechanism which inhibits inflammation via alpha 7 nicotinic acetylcholine receptor (\u03b17nAChR) signal transduction, to prevent cytokine storm.\n\nThe potential anti-inflammatory effects of famotidine and other H2R antagonists were assessed in mice exposed to lipopolysaccharide (LPS)-induced cytokine storm. As the inflammatory reflex is integrated and can be stimulated in the brain, and H2R antagonists penetrate the blood brain barrier poorly, famotidine was administered by intracerebroventricular (ICV) or intraperitoneal (IP) routes.\n\nFamotidine administered IP significantly reduced serum and splenic LPS-stimulated tumor necrosis factor (TNF) and IL-6 concentrations, significantly improving survival. The effects of ICV famotidine were significantly more potent as compared to the peripheral route. Mice lacking mast cells by genetic deletion also responded to famotidine, indicating the anti-inflammatory effects are not mast cell-dependent. Either bilateral sub-diaphragmatic vagotomy or genetic knock-out of \u03b17nAChR abolished the anti-inflammatory effects of famotidine, indicating the inflammatory reflex as famotidine's mechanism of action. While the structurally similar H2R antagonist tiotidine displayed equivalent anti-inflammatory activity, the H2R antagonists cimetidine or ranitidine were ineffective even at very high dosages.\n\nThese observations reveal a previously unidentified vagus nerve-dependent anti-inflammatory effect of famotidine in the setting of cytokine storm which is not replicated by high dosages of other H2R antagonists in clinical use. Because famotidine is more potent when administered intrathecally, these findings are also consistent with a primarily central nervous system mechanism of action.", "doi": "10.1186/s10020-022-00483-8", "pmid": "35578169", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s10020-022-00483-8"}, {"db": "pmc", "key": "PMC9109205"}], "notes": [], "created": "2022-06-21T18:05:26.861Z", "modified": "2022-06-21T18:05:26.918Z"}, {"entity": "publication", "iuid": "290bd3e7e98540d4a01daf46ec50d260", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/290bd3e7e98540d4a01daf46ec50d260.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/290bd3e7e98540d4a01daf46ec50d260"}}, "title": "Expecting parents' perceptions of the digital parental support \"childbirth journey\" constructed as a serious game-an intervention study.", "authors": [{"family": "B\u00e4ckstr\u00f6m", "given": "Caroline", "initials": "C", "orcid": "0000-0003-3347-482X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/362a5834f28143df864284ea02c275d8.json"}}, {"family": "Rolfson", "given": "Tanja", "initials": "T"}, {"family": "Engstr\u00f6m", "given": "Henrik", "initials": "H"}, {"family": "Knez", "given": "Rajna", "initials": "R"}, {"family": "Larsson", "given": "Margaretha", "initials": "M"}], "type": "journal article", "published": "2022-05-16", "journal": {"title": "Digit Health", "issn": "2055-2076", "volume": "8", "pages": "20552076221097776", "issn-l": null}, "abstract": "The aim of this study was to explore expecting parents' perceptions of the Childbirth Journey as an intervention that includes medical information for parental support, constructed as a serious game.\n\nIn this qualitative study, semi-structured interviews were held with expecting parents in Sweden who were able to talk about specific parts of the Childbirth Journey they appreciated or found difficult to understand. A phenomenographic methodology was employed for data analysis.\n\nParticipants perceived the Childbirth Journey to be easily accessible and customized with reliable information. The design and features of the intervention were perceived by the expecting parents to enhance the intervention's usability, appeal, and trustworthiness. When parental couples used the Childbirth Journey together, it gave them an opportunity to discuss and better understand each other's situation. The participants proposed several changes to the existing version of the game, mostly related to extending practical information and illustrated scenarios but also to the further development of the game's design and animations. The participants found the Knowledge portal to be the most appealing part of the Childbirth Journey.\n\nThe Childbirth Journey intervention was concluded to be a valuable digital complement to in-person professional support, especially given the current COVID-19 pandemic restrictions in place in Sweden, which do not allow antenatal visits by partners. However, in its current form, the Childbirth Journey has some deficiencies and would therefore benefit from further development and exploration.", "doi": "10.1177/20552076221097776", "pmid": "35603330", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1177_20552076221097776"}, {"db": "pmc", "key": "PMC9118415"}], "notes": [], "created": "2022-06-21T17:54:46.934Z", "modified": "2022-06-21T17:54:47.025Z"}, {"entity": "publication", "iuid": "3602a2b29b9e424cb4e96bbc15b426bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3602a2b29b9e424cb4e96bbc15b426bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3602a2b29b9e424cb4e96bbc15b426bf"}}, "title": "Complex Mutation Pattern of Omicron BA.2: Evading Antibodies without Losing Receptor Interactions.", "authors": [{"family": "Kannan", "given": "Saathvik R", "initials": "SR"}, {"family": "Spratt", "given": "Austin N", "initials": "AN"}, {"family": "Sharma", "given": "Kalicharan", "initials": "K", "orcid": "0000-0003-0333-2521", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/866b6de8eb3d4073a864e907c70a2c4d.json"}}, {"family": "Goyal", "given": "Ramesh", "initials": "R"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Apparsundaram", "given": "Subbu", "initials": "S"}, {"family": "Lorson", "given": "Christian L", "initials": "CL", "orcid": "0000-0002-1023-2169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58e32f41dbfe4d8a9c1debb7243baa61.json"}}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN", "orcid": "0000-0002-6889-4640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4cbe48df5ac74ffcb8a16b4f6775be1f.json"}}, {"family": "Singh", "given": "Kamal", "initials": "K", "orcid": "0000-0001-6153-8929", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b751253db0945c2b78dc4361b522a19.json"}}], "type": "journal article", "published": "2022-05-16", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "23", "issue": "10", "issn-l": null}, "abstract": "BA.2, a sublineage of Omicron BA.1, is now prominent in many parts of the world. Early reports have indicated that BA.2 is more infectious than BA.1. To gain insight into BA.2 mutation profile and the resulting impact of mutations on interactions with receptor and/or monoclonal antibodies, we analyzed available sequences, structures of Spike/receptor and Spike/antibody complexes, and conducted molecular dynamics simulations. The results showed that BA.2 had 50 high-prevalent mutations, compared to 48 in BA.1. Additionally, 17 BA.1 mutations were not present in BA.2. Instead, BA.2 had 19 unique mutations and a signature Delta variant mutation (G142D). The BA.2 had 28 signature mutations in Spike, compared to 30 in BA.1. This was due to two revertant mutations, S446G and S496G, in the receptor-binding domain (RBD), making BA.2 somewhat similar to Wuhan-Hu-1 (WT), which had G446 and G496. The molecular dynamics simulations showed that the RBD consisting of G446/G496 was more stable than S446/S496 containing RBD. Thus, our analyses suggested that BA.2 evolved with novel mutations (i) to maintain receptor binding similar to WT, (ii) evade the antibody binding greater than BA.1, and (iii) acquire mutation of the Delta variant that may be associated with the high infectivity.", "doi": "10.3390/ijms23105534", "pmid": "35628343", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Category: Omicron VoC": null}, "xrefs": [{"db": "pii", "key": "ijms23105534"}], "notes": [], "created": "2022-06-21T17:40:33.765Z", "modified": "2022-06-21T17:40:43.645Z"}, {"entity": "publication", "iuid": "673d03ccbe7d4a669271abf771c68df8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/673d03ccbe7d4a669271abf771c68df8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/673d03ccbe7d4a669271abf771c68df8"}}, "title": "Intention to get COVID-19 vaccination and its associated predictors: A cross-sectional study among the general public in Algeria.", "authors": [{"family": "Lounis", "given": "Mohamed", "initials": "M"}, {"family": "Abdelhadi", "given": "Samir", "initials": "S"}, {"family": "Rais", "given": "Mohammed Amir", "initials": "MA"}, {"family": "Bencherit", "given": "Djihad", "initials": "D"}, {"family": "Sallam", "given": "Malik", "initials": "M"}], "type": "journal article", "published": "2022-05-13", "journal": {"title": "Vacunas", "issn": "1576-9887", "issn-l": null}, "abstract": "Hesitancy towards COVID-19 vaccination and its rejection remains a major public health concern worldwide, especially in the Middle East and North African countries. The current study aimed to assess the intentions to get COVID-19 vaccines and its determinants among the general public in Algeria.\n\nA self-administered online survey was distributed during August-September 2021 using a convenience-based sampling approach. Data were collected anonymously and analyzed using IBM SPSS v22.0 software.\n\nThe study sample comprised a total of 656 participants, with 51.1% being in favor of COVID-19 vaccines while 18.5% and 30.5% were against or hesitant respectively. Only 38.6% among the study participants got vaccinated. Factors associated with higher odds of acceptance were: male sex, healthcare profession, the belief in natural origin of the pandemic and previous COVID-19 infection in family. The most common cited reasons for COVID-19 vaccine acceptance were the belief that vaccination is the only way to fight COVID-19 and the fear of getting infected by the virus; while the most common reasons of rejection were lack of trust in proper vaccine testing and fear of side effects.\n\nThe overall level of COVID-19 vaccine acceptance in this study was below the levels required to achieve population immunity. Besides certain socio-demographic characteristics, the determinants of COVID-19 vaccine rejection included the embrace of conspiratorial ideas regarding the virus and its vaccination. This should be considered in implementation of interventional measures aiming to promote COVID-19 vaccination in the country.", "doi": "10.1016/j.vacun.2022.04.003", "pmid": "35813989", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1576-9887(22)00039-5"}, {"db": "pmc", "key": "PMC9256516"}], "notes": [], "created": "2022-08-17T10:38:52.801Z", "modified": "2022-08-17T10:38:52.837Z"}, {"entity": "publication", "iuid": "0d15c6a7e22d443f955437406fe427cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d15c6a7e22d443f955437406fe427cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d15c6a7e22d443f955437406fe427cf"}}, "title": "COVID-19 Impact on Household Food Security in Urban and Peri-Urban Areas of Hyderabad, India.", "authors": [{"family": "Padmaja", "given": "Ravula", "initials": "R"}, {"family": "Nedumaran", "given": "Swamikannu", "initials": "S"}, {"family": "Jyosthnaa", "given": "Padmanabhan", "initials": "P"}, {"family": "Kavitha", "given": "Kasala", "initials": "K"}, {"family": "Abu Hatab", "given": "Assem", "initials": "A"}, {"family": "Lagerkvist", "given": "Carl-Johan", "initials": "CJ"}], "type": "journal article", "published": "2022-05-13", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "10", "pages": "814112", "issn-l": "2296-2565"}, "abstract": "This paper investigates the impact of the COVID-19 pandemic on food security and on coping-strategies in urban and peri-urban areas of the Hyderabad, India. Household survey data were collected before (October 2018) and during (January 2021) the onset of the pandemic. Results from logistic regression with the standarized Food Insecurity Expecience Scale (FIES) as dependent variable reveal that close to 40% of the households surveyed experienced a deterioration in food security status during the pandemic. In particular, we find that food security is closely related to the sector of employment in which the primary income- earning member of a household is engaged. To mitigate the impact of the pandemic on their food security, our sampled households adopted a variety of consumption-smoothing strategies including availing credit from both formal and informal sources, and liquidating their savings. Compared to households with severe or moderate level of food insecurity, households facing a mild level of food insecurity relied on stored food as a strategy to smoothen consumption in response to the income shock imparted by the pandemic. In addition, the results indicate that urban households, who adopted similar coping strategies as those adopted by peri-urban households, tended to be more food-insecure. Finally, the duration of unemployment experienced during the pandemic significantly influenced the status of household food security. These findings can inform the formulation of immediate and medium-term policy responses, including social protection policies conductive to mitigating the impacts of the COVID-19 pandemic and ameliorating the governance of urban food security during unexpected events and shocks.", "doi": "10.3389/fpubh.2022.814112", "pmid": "35646805", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9136225"}], "notes": [], "created": "2022-06-21T17:33:21.216Z", "modified": "2022-06-21T17:33:21.232Z"}, {"entity": "publication", "iuid": "50a3e8646978441c839206df02532bc5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50a3e8646978441c839206df02532bc5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50a3e8646978441c839206df02532bc5"}}, "title": "Quality of the Healthcare Services During COVID-19 Pandemic in Selected European Countries.", "authors": [{"family": "Tuczy\u0144ska", "given": "Magdalena", "initials": "M"}, {"family": "Staszewski", "given": "Rafa\u0142", "initials": "R"}, {"family": "Matthews-Kozanecka", "given": "Maja", "initials": "M"}, {"family": "\u017bok", "given": "Agnieszka", "initials": "A"}, {"family": "Baum", "given": "Ewa", "initials": "E"}], "type": "journal article", "published": "2022-05-12", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "10", "pages": "870314", "issn-l": "2296-2565"}, "abstract": "There are several definitions of the quality of healthcare services. It may be defined as a level of value provided by any health care resource, as determined by some measurement. Scientists use a variety of quality measures to attempt to determine health care quality. They use special indicators or based on a patients' or healthcare professional's perception. This article aims to provide a short review of the available data on the quality of healthcare services in selected European countries during the COVID-19 pandemic.\n\nThe research was done by the use of online databases such as PubMed, Google Scholar, and Science Direct. All the studies focused on the quality of healthcare services, yet the studies used different methods to measure this quality. In addition, the results of the authors' survey on the assessment of the quality of healthcare services before and during the COVID-19 pandemic were presented.\n\nAmong twelve studies, four were from the United Kingdom and one each of Catalonia, Italy, Sweden, Poland, Netherlands, France, Germany, Belgium. Patients in the United Kingdom felt that the quality of services was good during the pandemic, whereas the quality declined in the other studies cited. The results of our research also revealed a decrease in the quality of healthcare services provided.\n\nNevertheless the development of telemedicine has had a positive impact on the quality of healthcare services. The COVID-19 pandemic has undoubtedly affected most European countries' quality of healthcare services.", "doi": "10.3389/fpubh.2022.870314", "pmid": "35646786", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9133554"}], "notes": [], "created": "2022-06-21T17:33:41.928Z", "modified": "2022-06-21T17:33:41.942Z"}, {"entity": "publication", "iuid": "4771805ee90843d9ae54590d2abd7a7b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4771805ee90843d9ae54590d2abd7a7b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4771805ee90843d9ae54590d2abd7a7b"}}, "title": "Barriers and Facilitators to Receiving the COVID-19 Vaccination and Development of Theoretically-Informed Implementation Strategies for the Public: Qualitative Study in Hong Kong.", "authors": [{"family": "Wong", "given": "Charlene Hl", "initials": "CH", "orcid": "0000-0003-2623-5855", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0db6ceb15388473bb3a8c6128aa67716.json"}}, {"family": "Zhong", "given": "Claire Cw", "initials": "CC"}, {"family": "Chung", "given": "Vincent Ch", "initials": "VC"}, {"family": "Nilsen", "given": "Per", "initials": "P"}, {"family": "Wong", "given": "Eliza Ly", "initials": "EL", "orcid": "0000-0001-9983-6219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32f2cac9d18445a7b5de24251c6f6be4.json"}}, {"family": "Yeoh", "given": "Eng-Kiong", "initials": "EK"}], "type": "journal article", "published": "2022-05-12", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "5", "issn-l": null}, "abstract": "enhancing uptake of COVID-19 vaccines is an important tool for managing the pandemic. However, in Hong Kong, the COVID-19 vaccination rate in the general population was unsatisfactory during the early phase of the vaccination program. This two-part study aimed to (i) identify barriers and facilitators to receiving vaccinations, and (ii) develop theoretically-informed implementation strategies for promoting uptake.\n\nin part 1, 45 Hong Kong residents who differed in their willingness to vaccinate (willing (n = 15), were unwilling (n = 15), and were hesitant (n = 15)), were interviewed individually in February 2021. They were invited to express their perceptions of receiving the COVID-19 vaccination. The theoretical domains framework (TDF) was applied to guide the interviews and analyses. Behavioral diagnoses from these findings were then used to develop theoretically-informed implementation strategies in part 2, composed of behavior change techniques (BCTs) informed by the established BCT taxonomy.\n\nin part 1, the five main barriers were (i) concerns on severe and long-term side effects; (ii) low confidence in the safety and effectiveness due to concerns of their accelerated development; (iii) unclear information on logistical arrangements of the vaccination program; (iv) insufficient data on safety and effectiveness; and (v) perceived low protection ability conferred by the vaccines. The five main facilitators included (i) healthcare professionals' recommendations; (ii) news from TV, radio, and newspapers as main sources of trustworthy information; (iii) vaccine-related health education delivered by healthcare professionals; (iv) expectations of resuming to a normal social life; and (v) perceived benefits outweighing risks of mild and short-term side effects.\n\nseven implementation strategies were developed in part 2 based on the results above, namely (i) providing trustworthy vaccine-related information and scaling up the promotion; (ii) encouraging healthcare professionals to recommend vaccinations; (iii) giving incentives; (iv) using social influence approaches; (v) allowing a selection of COVID-19 vaccine brands; (vi) increasing accessibility for vaccinations; and (vii) emphasizing social responsibility.", "doi": "10.3390/vaccines10050764", "pmid": "35632520", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "vaccines10050764"}], "notes": [], "created": "2022-06-21T17:39:57.144Z", "modified": "2022-06-21T17:40:13.283Z"}, {"entity": "publication", "iuid": "1b10339b6f5f442bbbd6b427f97707ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b10339b6f5f442bbbd6b427f97707ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b10339b6f5f442bbbd6b427f97707ff"}}, "title": "A Feasibility Study of a Remotely-Delivered Mindfulness-Based Training for Adolescents During the COVID-19 Pandemic.", "authors": [{"family": "Tymofiyeva", "given": "Olga", "initials": "O"}, {"family": "Hu", "given": "Melody Y", "initials": "MY"}, {"family": "Sipes", "given": "Benjamin S", "initials": "BS"}, {"family": "Jakary", "given": "Angela", "initials": "A"}, {"family": "Glidden", "given": "David V", "initials": "DV"}, {"family": "Jariwala", "given": "Namasvi", "initials": "N"}, {"family": "Bhandari", "given": "Sarina", "initials": "S"}, {"family": "Parks", "given": "Kendall C", "initials": "KC"}, {"family": "Nguyen", "given": "Ca", "initials": "C"}, {"family": "Henje", "given": "Eva", "initials": "E"}, {"family": "Yang", "given": "Tony T", "initials": "TT"}], "type": "journal article", "published": "2022-05-12", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "13", "pages": "838694", "issn-l": "1664-0640"}, "abstract": "Social distancing, home confinement, economic challenges, and COVID-19-related illness and deaths during the COVID-19 pandemic can significantly affect mental health in youth. One promising approach to reduce anxiety and depression in adolescents is the neuroscience-based mindfulness intervention Training for Awareness, Resilience, and Action (TARA). The objective of this individually randomized waitlist-controlled trial (RCT) was (1) to test the feasibility of TARA, delivered partially over Zoom, and (2) to assess changes in the emotional wellbeing in healthy adolescents between the ages of 14-18 years old during the COVID-19 pandemic.\n\nTwenty-one healthy adolescents were randomized to the TARA intervention or to the waitlist control group in February 2020, just before the start of the pandemic. The TARA group intervention was delivered in person for the first five sessions and remotely over Zoom for the remaining seven sessions due to the pandemic. The participants' acceptability of TARA was assessed weekly using the Child Session Rating Scale (CSRS). The primary outcome was the emotional wellbeing measured using emotional symptoms subscale of the Strengths and Difficulties Questionnaire (SDQ) pre/post-TARA. We also explored weekly changes in TARA participants' wellbeing using the Child Outcome Rating Scale (CORS).\n\nThe overall session rating in TARA participants improved after the switch to Zoom (Cohen's d = 1.2, p = 0.008). The results of the two-way ANOVA showed no statistically significant difference in the change of the SDQ emotional symptoms during the 12 weeks between the TARA group and waitlist-control group (timepoint \u00d7 group interaction: F = 0.77, p = 0.38). The exploratory analysis using the CORS in the TARA participants showed a significant improvement in their functioning over the weeks of training.\n\nOur results support the feasibility of TARA delivered over Zoom. While our primary outcome did not provide support for the improvement of the emotional wellbeing with TARA compared to a passive control group, our exploratory analysis in the intervention group indicated an improved functioning over the weeks of TARA training. The important general positive impact of this study lies in the possibility of offering a neuroscience-based mindfulness intervention remotely to youth living in remote areas and for all youth during pandemic times.", "doi": "10.3389/fpsyt.2022.838694", "pmid": "35633797", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9133427"}], "notes": [], "created": "2022-06-21T17:38:49.218Z", "modified": "2022-06-21T17:39:01.924Z"}, {"entity": "publication", "iuid": "588e28d247da46e8a413f4f2f7380555", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/588e28d247da46e8a413f4f2f7380555.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/588e28d247da46e8a413f4f2f7380555"}}, "title": "Comparison of years of life lost to 1,565 suicides versus 10,650 COVID-19 deaths in 2020 in Sweden: four times more years of life lost per suicide than per COVID-19 death.", "authors": [{"family": "Ljung", "given": "Rickard", "initials": "R", "orcid": "0000-0002-0654-4530", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ba40c2b98b1442192811ba44ffbf967.json"}}, {"family": "Gr\u00fcnewald", "given": "Maria", "initials": "M", "orcid": "0000-0002-9280-8140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c1e75524a543e6a9f6177f8d7791e2.json"}}, {"family": "Sundstr\u00f6m", "given": "Anders", "initials": "A", "orcid": "0000-0003-2337-3371", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5acbd5b816884f06807b23bd3e2e6cad.json"}}, {"family": "Sundbom", "given": "Lena Thunander", "initials": "LT"}, {"family": "Zethelius", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-1738-0834", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed68e20a415f43d4882fdb44c2e4ee21.json"}}], "type": "journal article", "published": "2022-05-11", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "volume": "127", "issn-l": "0300-9734"}, "abstract": "The burden of disease from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is large; however, suicide affects the population year after year. From a public health perspective, it is important to not neglect contributors to the total burden of disease. The aim of this paper is to compare years of life lost (YLL) to suicide with those lost to coronavirus disease 2019 (COVID-19).\n\nA nationwide cohort study in 2020, in Sweden. YLL was measured as the sex- and age-specific remaining life expectancy at the time of the person's death based on the death risks that pertained to the Swedish population in 2019. YLL to suicide was compared to YLL to COVID-19 and presented by sex and age groups. Suicide deaths in 2020 were estimated as the annual average of suicides in 2015-2019.\n\nAnnual average of suicide was 1,565, whereof 1,076 (68.8%) men and 489 (31.2%) women. In 2020, 10,650 persons died of COVID-19, whereof 5,681 (53.3%) men and 4,969 (46.7%) women. Estimated total YLL to suicide and COVID-19 in 2020 was 53,237 and 90,116, respectively. The COVID-19 YLL to suicide YLL ratio in 2020 was 1.69 (90,116/53,237). Men accounted for 67.1% of suicide YLL and of 56.4% of COVID-19 YLL. Those 44 years or younger accounted for 60.3% of suicide YLL and 3.9% of COVID-19 YLL. Those 75 years and older accounted for 2.9% of suicide YLL and 60.9% of COVID-19 YLL. On average, each suicide generates 34 YLL (53,237/1,565), and each COVID-19 death generates 8.5 YLL (90,116/10,650).\n\nYLL to suicide affects Sweden year after year, foremost attributable to the younger age groups, whereas YLL to COVID-19 is foremost attributable to the elderly. On average, each suicide generates four times more YLL than a COVID-19 death. Enormous efforts and resources have been put on tackling the pandemic, and without these, the burden would probably have been much larger. However, from a public health perspective, it is important to not neglect other contributors to the total burden of disease where national efforts also may have an impact.", "doi": "10.48101/ujms.v127.8533", "pmid": "35722184", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC9169542"}, {"db": "pii", "key": "8533"}], "notes": [], "created": "2022-06-20T18:04:55.929Z", "modified": "2023-01-13T13:40:05.469Z"}, {"entity": "publication", "iuid": "6f6f1f88f28e45819836de1ae35e3526", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f6f1f88f28e45819836de1ae35e3526.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f6f1f88f28e45819836de1ae35e3526"}}, "title": "Can diffusion tensor imaging (DTI) outperform standard magnetic resonance imaging (MRI) investigations in post-COVID-19 autoimmune encephalitis?", "authors": [{"family": "Latini", "given": "Francesco", "initials": "F", "orcid": "0000-0002-4702-526X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30e6260671fb44f4b80218f9acc037fd.json"}}, {"family": "Fahlstr\u00f6m", "given": "Markus", "initials": "M", "orcid": "0000-0002-2502-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce71adf67a984cf6aa8ec4a32cf1d664.json"}}, {"family": "F\u00e4llmar", "given": "David", "initials": "D", "orcid": "0000-0001-5615-2036", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08e1206ab94a43788a7fc641ee13407c.json"}}, {"family": "Marklund", "given": "Niklas", "initials": "N", "orcid": "0000-0002-9797-5626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b0d761a3f60485587650286412498b9.json"}}, {"family": "Cunningham", "given": "Janet L", "initials": "JL", "orcid": "0000-0001-7876-7779", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2f65143e6e34510a93df76eb96d0d7f.json"}}, {"family": "Feresiadou", "given": "Amalia", "initials": "A"}], "type": "journal article", "published": "2022-05-10", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "volume": "127", "issn-l": "0300-9734"}, "abstract": "Neurological and psychiatric manifestations related to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection are widely recognised. Standard magnetic resonance imaging (MRI) investigations are normal in 40-80% of symptomatic patients, eventually delaying appropriate treatment when MRI is unrevealing any structural changes. The aim of this study is to investigate white matter abnormalities during an early stage of post-COVID-19 (coronavirus disease 2019) encephalitis while conventional MRI was normal.\n\nA patient with post-COVID-19 autoimmune encephalitis was investigated by serial MRIs and diffusion tensor imaging (DTI). Ten healthy control individuals (HC) were utilised as a control group for the DTI analysis. Major projection, commissural and association white matter pathways were reconstructed, and multiple diffusion parameters were analysed and then compared to the HC average using a z-test for serial examinations.\n\nEleven days after the onset of neurological symptoms, DTI revealed early white matter changes, compared with HC, when standard MRI was normal. On day 68, DTI showed multiple white matter lesions compared with HC, visible at this time also by the MRI images, indicating inflammatory changes in different association and projection white matter pathways.\n\nWe confirm a limitation in the sensitivity of conventional MRI at the acute setting of post-COVID-19 autoimmune encephalitis. A complementary DTI investigation could be a valuable diagnostic tool in early therapeutic decisions concerning COVID-19-related neurological symptoms.", "doi": "10.48101/ujms.v127.8562", "pmid": "35722186", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "8562"}, {"db": "pmc", "key": "PMC9169543"}], "notes": [], "created": "2022-06-20T18:04:34.750Z", "modified": "2022-08-17T12:45:48.904Z"}, {"entity": "publication", "iuid": "24b14ce13196447b8ec446d4ed60d709", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24b14ce13196447b8ec446d4ed60d709.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24b14ce13196447b8ec446d4ed60d709"}}, "title": "Viral Antigen and Inflammatory Biomarkers in Cerebrospinal Fluid in Patients With COVID-19 Infection and Neurologic Symptoms Compared With Control Participants Without Infection or Neurologic Symptoms.", "authors": [{"family": "Ed\u00e9n", "given": "Arvid", "initials": "A"}, {"family": "Grahn", "given": "Anna", "initials": "A"}, {"family": "Bremell", "given": "Daniel", "initials": "D"}, {"family": "Aghvanyan", "given": "Anahit", "initials": "A"}, {"family": "Bathala", "given": "Pradeepthi", "initials": "P"}, {"family": "Fuchs", "given": "Dietmar", "initials": "D"}, {"family": "Gostner", "given": "Johanna", "initials": "J"}, {"family": "Hagberg", "given": "Lars", "initials": "L"}, {"family": "Kanberg", "given": "Nelly", "initials": "N"}, {"family": "Kanjananimmanont", "given": "Sunsanee", "initials": "S"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Misaghian", "given": "Salvia", "initials": "S"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Sch\u00f6ll", "given": "Michael", "initials": "M"}, {"family": "Sigal", "given": "George", "initials": "G"}, {"family": "Stentoft", "given": "Erika", "initials": "E"}, {"family": "Studahl", "given": "Marie", "initials": "M"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Wang", "given": "Mingyue", "initials": "M"}, {"family": "Stengelin", "given": "Martin", "initials": "M"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2022-05-02", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "volume": "5", "issue": "5", "pages": "e2213253", "issn-l": null}, "abstract": "Neurologic symptoms are common in COVID-19, but the central nervous system (CNS) pathogenesis is unclear, and viral RNA is rarely detected in cerebrospinal fluid (CSF).\n\nTo measure viral antigen and inflammatory biomarkers in CSF in relation to neurologic symptoms and disease severity.\n\nThis cross-sectional study was performed from March 1, 2020, to June 30, 2021, in patients 18 years or older who were admitted to Sahlgrenska University Hospital, Gothenburg, Sweden, with COVID-19. All patients had CSF samples taken because of neurologic symptoms or within a study protocol. Healthy volunteer and prepandemic control groups were included.\n\nSARS-CoV-2 infection.\n\nOutcomes included CSF SARS-CoV-2 nucleocapsid antigen (N-Ag) using an ultrasensitive antigen capture immunoassay platform and CSF biomarkers of immune activation (neopterin, \u03b22-microglobulin, and cytokines) and neuronal injury (neurofilament light protein [NfL]).\n\nForty-four patients (median [IQR] age, 57 [48-69] years; 30 [68%] male; 26 with moderate COVID-19 and 18 with severe COVID-19 based on the World Health Organization Clinical Progression Scale), 10 healthy controls (median [IQR] age, 58 [54-60] years; 5 [50%] male), and 41 patient controls (COVID negative without evidence of CNS infection) (median [IQR] age, 59 [49-70] years; 19 [46%] male) were included in the study. Twenty-one patients were neuroasymptomatic and 23 were neurosymptomatic (21 with encephalopathy). In 31 of 35 patients for whom data were available (89%), CSF N-Ag was detected; viral RNA test results were negative in all. Nucleocapsid antigen was significantly correlated with CSF neopterin (r = 0.38; P = .03) and interferon \u03b3 (r = 0.42; P = .01). No differences in CSF N-Ag concentrations were found between patient groups. Patients had markedly increased CSF neopterin, \u03b22-microglobulin, interleukin (IL) 2, IL-6, IL-10, and tumor necrosis factor \u03b1 compared with controls. Neurosymptomatic patients had significantly higher median (IQR) CSF interferon \u03b3 (86 [47-172] vs 21 [17-81] fg/mL; P = .03) and had a significantly higher inflammatory biomarker profile using principal component analysis compared with neuroasymptomatic patients (0.54; 95% CI, 0.03-1.05; P = .04). Age-adjusted median (IQR) CSF NfL concentrations were higher in patients compared with controls (960 [673-1307] vs 618 [489-786] ng/L; P = .002). No differences were seen in any CSF biomarkers in moderate compared with severe disease.\n\nIn this study of Swedish adults with COVID-19 infection and neurologic symptoms, compared with control participants, viral antigen was detectable in CSF and correlated with CNS immune activation. Patients with COVID-19 had signs of neuroaxonal injury, and neurosymptomatic patients had a more marked inflammatory profile that could not be attributed to differences in COVID-19 severity. These results highlight the clinical relevance of neurologic symptoms and suggest that viral components can contribute to CNS immune responses without direct viral invasion.", "doi": "10.1001/jamanetworkopen.2022.13253", "pmid": "35604688", "labels": {"Category: Biochemistry": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9127556"}, {"db": "pii", "key": "2792536"}], "notes": [], "created": "2022-06-21T17:54:22.642Z", "modified": "2023-06-19T14:45:22.640Z"}, {"entity": "publication", "iuid": "3739638ad7c44737924091555557a402", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3739638ad7c44737924091555557a402.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3739638ad7c44737924091555557a402"}}, "title": "Severe acute respiratory syndrome coronavirus 2 can be detected in exhaled aerosol sampled during a few minutes of breathing or coughing.", "authors": [{"family": "Viklund", "given": "Emilia", "initials": "E", "orcid": "0000-0003-4453-4680", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/332056bb6e88414d9f72c513b31c7959.json"}}, {"family": "Kokelj", "given": "Spela", "initials": "S"}, {"family": "Larsson", "given": "Per", "initials": "P"}, {"family": "Nord\u00e9n", "given": "Rickard", "initials": "R"}, {"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Beck", "given": "Olof", "initials": "O"}, {"family": "Westin", "given": "Johan", "initials": "J"}, {"family": "Olin", "given": "Anna-Carin", "initials": "AC"}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "Influenza Other Respir Viruses", "issn": "1750-2659", "volume": "16", "issue": "3", "pages": "402-410", "issn-l": null}, "abstract": "The knowledge on the concentration of viral particles in exhaled breath is limited. The aim of this study was to explore if severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be detected in aerosol from subjects with the coronavirus disease 2019 (COVID-19) during various types of breathing and coughing and how infection with SARS-CoV-2 may influence the number and size of exhaled aerosol particles.\n\nWe counted and collected endogenous particles in exhaled breath in subjects with COVID-19 disease by two different impaction-based methods, during 20 normal breaths, 10 airway opening breaths, and three coughs, respectively. Breath samples were analyzed with reverse transcription real-time polymerase chain reaction (RT-PCR).\n\nDetection of RNA in aerosol was possible in 10 out of 25 subjects. Presence of virus RNA in aerosol was mainly found in cough samples (n = 8), but also in airway opening breaths (n = 3) and in normal breaths (n = 4), with no overlap between the methods. No association between viral load in aerosol and number exhaled particles <5 \u03bcm was found. Subjects with COVID-19 exhaled less particles than healthy controls during normal breathing and airway opening breaths (all P < 0.05), but not during cough.\n\nSARS-CoV-2 RNA can be detected in exhaled aerosol, sampled during a limited number of breathing and coughing procedures. Detection in aerosol seemed independent of viral load in the upper airway swab as well as of the exhaled number of particles. The infectious potential of the amount of virus detected in aerosol needs to be further explored.", "doi": "10.1111/irv.12964", "pmid": "35037404", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8983906"}], "notes": [], "created": "2022-01-27T07:38:28.676Z", "modified": "2023-06-19T14:19:39.990Z"}, {"entity": "publication", "iuid": "a25e4faab1cd435db55f17485fb41713", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a25e4faab1cd435db55f17485fb41713.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a25e4faab1cd435db55f17485fb41713"}}, "title": "Potential neurological manifestations of COVID-19: a narrative review.", "authors": [{"family": "Pergolizzi", "given": "Joseph V", "initials": "JV", "orcid": "0000-0001-5658-1471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b411beeaa47641bca832e58b7c6a9a69.json"}}, {"family": "Raffa", "given": "Robert B", "initials": "RB", "orcid": "0000-0002-1456-4451", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040955e0221f405494e8870d61dc0378.json"}}, {"family": "Varrassi", "given": "Giustino", "initials": "G", "orcid": "0000-0002-3822-2923", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c88c160784934b09ae6e4d0303fc71b7.json"}}, {"family": "Magnusson", "given": "Peter", "initials": "P", "orcid": "0000-0001-7906-7782", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9484ae1472fe43b39127b01810ffff33.json"}}, {"family": "LeQuang", "given": "Jo Ann", "initials": "JA", "orcid": "0000-0003-4794-0318", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f96aac587798429da2324c43ad9813fa.json"}}, {"family": "Paladini", "given": "Antonella", "initials": "A", "orcid": "0000-0002-1219-9315", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/410a15dde4a84c92ab7c5700879accd8.json"}}, {"family": "Taylor", "given": "Robert", "initials": "R", "orcid": "0000-0001-5971-361X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21635cc313974dbabc0baaa7ac95f6f8.json"}}, {"family": "Wollmuth", "given": "Charles", "initials": "C"}, {"family": "Breve", "given": "Frank", "initials": "F"}, {"family": "Chopra", "given": "Maninder", "initials": "M"}, {"family": "Nalamasu", "given": "Rohit", "initials": "R"}, {"family": "Christo", "given": "Paul J", "initials": "PJ"}, {"family": "NEMA Research Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "Postgrad Med", "issn": "1941-9260", "volume": "134", "issue": "4", "pages": "395-405", "issn-l": "0032-5481"}, "abstract": "Neurological manifestations are increasingly reported in a subset of COVID-19 patients. Previous infections related to coronaviruses, namely Severe Acute Respiratory Syndrome (SARS) and Middle Eastern Respiratory Syndrome (MERS) also appeared to have neurological effects on some patients. The viruses associated with COVID-19 like that of SARS enters the body via the ACE-2 receptors in the central nervous system, which causes the body to balance an immune response against potential damage to nonrenewable cells. A few rare cases of neurological sequelae of SARS and MERS have been reported. A growing body of evidence is accumulating that COVID-19, particularly in severe cases, may have neurological consequences although respiratory symptoms nearly always develop prior to neurological ones. Patients with preexisting neurological conditions may be at elevated risk for COVID-19-associated neurological symptoms. Neurological reports in COVID-19 patients have described encephalopathy, Guillain-Barr\u00e9 syndrome, myopathy, neuromuscular disorders, encephalitis, cephalgia, delirium, critical illness polyneuropathy, and others. Treating neurological symptoms can pose clinical challenges as drugs that suppress immune response may be contraindicated in COVID-19 patients. It is possible that in some COVID-19 patients, neurological symptoms are being overlooked or misinterpreted. To date, neurological manifestations of COVID-19 have been described largely within the disease trajectory and the long-term effects of such manifestations remain unknown.", "doi": "10.1080/00325481.2020.1837503", "pmid": "33089707", "labels": {"Category: Social Science & Humanities": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7799377"}], "notes": [], "created": "2020-11-26T12:16:31.652Z", "modified": "2023-01-13T14:45:28.997Z"}, {"entity": "publication", "iuid": "fce5800c723041d8b1c9b8dcc8e7def2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fce5800c723041d8b1c9b8dcc8e7def2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fce5800c723041d8b1c9b8dcc8e7def2"}}, "title": "Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: Update of a living systematic review and meta-analysis.", "authors": [{"family": "Buitrago-Garcia", "given": "Diana", "initials": "D", "orcid": "0000-0001-9761-206X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21246f1ed5d94488a97190a5e92f5488.json"}}, {"family": "Ipekci", "given": "Aziz Mert", "initials": "AM", "orcid": "0000-0002-0260-9691", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee8671294d5b43f48f76a93236a723be.json"}}, {"family": "Heron", "given": "Leonie", "initials": "L", "orcid": "0000-0002-3820-3343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/873b10a6c024425ebb7c8f6d994ed029.json"}}, {"family": "Imeri", "given": "Hira", "initials": "H", "orcid": "0000-0002-0412-1649", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f82db58c6c3e4bf48102085c1e24bd92.json"}}, {"family": "Araujo-Chaveron", "given": "Lucia", "initials": "L", "orcid": "0000-0002-2110-6088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54a422a247ea4393a3d7383d849f4e18.json"}}, {"family": "Arevalo-Rodriguez", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-7326-4504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28523e3462094df0ad816c3ca1b3cd3d.json"}}, {"family": "Ciapponi", "given": "Agust\u00edn", "initials": "A", "orcid": "0000-0001-5142-6122", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6493e266d9ec4eb0b2b206381516844b.json"}}, {"family": "Cevik", "given": "Muge", "initials": "M", "orcid": "0000-0003-1133-3874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90cabaf2381c4667aa0d4515fc2f3db2.json"}}, {"family": "Hauser", "given": "Anthony", "initials": "A", "orcid": "0000-0002-7221-1929", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4ad8a25f2854575af40c39f93c4c3ac.json"}}, {"family": "Alam", "given": "Muhammad Irfanul", "initials": "MI", "orcid": "0000-0002-8759-6585", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49edca8da0c3453f834d1fec4dfe3876.json"}}, {"family": "Meili", "given": "Kaspar", "initials": "K", "orcid": "0000-0002-9889-4406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a334f6359cd5436fa748f503c5ac24b6.json"}}, {"family": "Meyerowitz", "given": "Eric A", "initials": "EA", "orcid": "0000-0001-7954-6548", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b77f4eeebd94156bfd8b53716a61050.json"}}, {"family": "Prajapati", "given": "Nirmala", "initials": "N", "orcid": "0000-0001-7518-5968", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b573d28168b452aa168f42889153333.json"}}, {"family": "Qiu", "given": "Xueting", "initials": "X", "orcid": "0000-0001-6810-7304", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5eb2980535d4f9a8f6b8b02714545d0.json"}}, {"family": "Richterman", "given": "Aaron", "initials": "A", "orcid": "0000-0001-7920-7191", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13a2fc1e9cba4e16b79ebe473914d3ef.json"}}, {"family": "Robles-Rodriguez", "given": "William Gildardo", "initials": "WG", "orcid": "0000-0002-8383-6844", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c037505a5854c7cb4cc15f4a2c8505d.json"}}, {"family": "Thapa", "given": "Shabnam", "initials": "S"}, {"family": "Zhelyazkov", "given": "Ivan", "initials": "I", "orcid": "0000-0001-6320-7517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d3019d0c667b4d2a9cfc66e2f8cd1541.json"}}, {"family": "Salanti", "given": "Georgia", "initials": "G", "orcid": "0000-0002-3830-8508", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80f3be926d9c4f1a81d9a5ff4717a432.json"}}, {"family": "Low", "given": "Nicola", "initials": "N", "orcid": "0000-0003-4817-8986", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/acef6c2aaf2c4673be2ffe2e3dc5c17d.json"}}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "PLoS Med", "issn": "1549-1676", "volume": "19", "issue": "5", "pages": "e1003987", "issn-l": "1549-1277"}, "abstract": "Debate about the level of asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection continues. The amount of evidence is increasing and study designs have changed over time. We updated a living systematic review to address 3 questions: (1) Among people who become infected with SARS-CoV-2, what proportion does not experience symptoms at all during their infection? (2) What is the infectiousness of asymptomatic and presymptomatic, compared with symptomatic, SARS-CoV-2 infection? (3) What proportion of SARS-CoV-2 transmission in a population is accounted for by people who are asymptomatic or presymptomatic?\n\nThe protocol was first published on 1 April 2020 and last updated on 18 June 2021. We searched PubMed, Embase, bioRxiv, and medRxiv, aggregated in a database of SARS-CoV-2 literature, most recently on 6 July 2021. Studies of people with PCR-diagnosed SARS-CoV-2, which documented symptom status at the beginning and end of follow-up, or mathematical modelling studies were included. Studies restricted to people already diagnosed, of single individuals or families, or without sufficient follow-up were excluded. One reviewer extracted data and a second verified the extraction, with disagreement resolved by discussion or a third reviewer. Risk of bias in empirical studies was assessed with a bespoke checklist and modelling studies with a published checklist. All data syntheses were done using random effects models. Review question (1): We included 130 studies. Heterogeneity was high so we did not estimate a mean proportion of asymptomatic infections overall (interquartile range (IQR) 14% to 50%, prediction interval 2% to 90%), or in 84 studies based on screening of defined populations (IQR 20% to 65%, prediction interval 4% to 94%). In 46 studies based on contact or outbreak investigations, the summary proportion asymptomatic was 19% (95% confidence interval (CI) 15% to 25%, prediction interval 2% to 70%). (2) The secondary attack rate in contacts of people with asymptomatic infection compared with symptomatic infection was 0.32 (95% CI 0.16 to 0.64, prediction interval 0.11 to 0.95, 8 studies). (3) In 13 modelling studies fit to data, the proportion of all SARS-CoV-2 transmission from presymptomatic individuals was higher than from asymptomatic individuals. Limitations of the evidence include high heterogeneity and high risks of selection and information bias in studies that were not designed to measure persistently asymptomatic infection, and limited information about variants of concern or in people who have been vaccinated.\n\nBased on studies published up to July 2021, most SARS-CoV-2 infections were not persistently asymptomatic, and asymptomatic infections were less infectious than symptomatic infections. Summary estimates from meta-analysis may be misleading when variability between studies is extreme and prediction intervals should be presented. Future studies should determine the asymptomatic proportion of SARS-CoV-2 infections caused by variants of concern and in people with immunity following vaccination or previous infection. Without prospective longitudinal studies with methods that minimise selection and measurement biases, further updates with the study types included in this living systematic review are unlikely to be able to provide a reliable summary estimate of the proportion of asymptomatic infections caused by SARS-CoV-2.\n\nOpen Science Framework (https://osf.io/9ewys/).", "doi": "10.1371/journal.pmed.1003987", "pmid": "35617363", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "PMEDICINE-D-22-00260"}], "notes": [], "created": "2022-06-21T17:47:28.227Z", "modified": "2022-06-21T17:47:28.928Z"}, {"entity": "publication", "iuid": "3a73765806e14038a7f427e6cfaeea2e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a73765806e14038a7f427e6cfaeea2e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a73765806e14038a7f427e6cfaeea2e"}}, "title": "Moral Distress Among Operating Room Personnel During the COVID-19 Pandemic: A Qualitative Study", "authors": [{"family": "Fagerdahl", "given": "Ann Mari", "initials": "AM", "orcid": "0000-0002-9170-581X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ade5aac0a60a4ad1b19ccef36320e13e.json"}}, {"family": "Torbj\u00f6rnsson", "given": "Eva", "initials": "E"}, {"family": "Gustavsson", "given": "Martina", "initials": "M", "orcid": "0000-0002-6193-6289", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/658c2b521a9142d494ee474d9944d5b7.json"}}, {"family": "\u00c4lg\u00e5", "given": "Andreas", "initials": "A"}], "type": "journal-article", "published": "2022-05-00", "journal": {"title": "Journal of Surgical Research", "issn": "0022-4804", "volume": "273", "pages": "110-118", "issn-l": null}, "abstract": "The ongoing COVID-19 pandemic has necessitated the reallocation of healthcare resources, and a minimization of elective activities. Healthcare personnel involved in COVID-19 care have been negatively affected by the associated excess stress. The existing COVID-19 research has focused on the experiences among healthcare personnel in general, and not particularly on the operating room team members, who have often been relocated to overburdened workplaces. Therefore, we aimed to explore the experiences in this particular group.\n\nThis study has a qualitative inductive design based on interviews with a strategic sample of 12 operating room team members: surgeons, anesthesiologist, specialist nurses, and nurse assistants. The interviews were analyzed using content analysis.\n\nThree themes were identified: \"Feeling safe in the familiar and anxiety in the unknown\", \"To be the ones left behind\", and \"The possibility for recuperation in a seemingly everlasting situation\". The participants described working hard, although their efforts were experienced as not enough according to their moral ideals. We interpreted this as feelings and signs of moral distress, a commonly described concept in previous studies during the COVID-19 pandemic, and a risk for burn out.\n\nThe operating room team members emphasized the negative stress of being in the unknown, performing work tasks in an unfamiliar place and situation, and experiencing conflicting feelings of relief and guilt. Organizational strategies toward a functional leadership and support should be emphasized. Such strategies might reduce the risk of psychological consequences such as burn out.", "doi": "10.1016/j.jss.2021.12.011", "pmid": "35033820", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0022-4804(21)00740-X"}, {"db": "pmc", "key": "PMC8692083"}], "notes": [], "created": "2022-01-27T07:48:44.330Z", "modified": "2022-06-21T18:15:28.541Z"}, {"entity": "publication", "iuid": "e714e24b70654a99a7bda77f7eb68634", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e714e24b70654a99a7bda77f7eb68634.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e714e24b70654a99a7bda77f7eb68634"}}, "title": "Envisioning sustainable and equitable World Health Assemblies.", "authors": [{"family": "Khorsand", "given": "Parnian", "initials": "P", "orcid": "0000-0002-5347-1629", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5bcdb597d56c4e2a9141a03c59902375.json"}}, {"family": "Chowdhury", "given": "Maisoon", "initials": "M"}, {"family": "Wyns", "given": "Arthur", "initials": "A"}, {"family": "Velin", "given": "Lotta", "initials": "L", "orcid": "0000-0002-1929-6011", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c5b0a7da8a4eb19b92be09bbbef9b1.json"}}, {"family": "Wangari", "given": "Marie-Claire", "initials": "MC", "orcid": "0000-0002-4529-8133", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31a1675605154adda9fef1e2b842a291.json"}}, {"family": "Cipriano", "given": "Gabriela", "initials": "G"}, {"family": "El Omrani", "given": "Omnia", "initials": "O", "orcid": "0000-0002-1655-1195", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4eaa1ea11e884f49a9c60f7f9cd2bc74.json"}}, {"family": "Patil", "given": "Poorvaprabha", "initials": "P"}, {"family": "van Daalen", "given": "Kim", "initials": "K"}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "7", "issue": "5", "issn-l": "2059-7908"}, "abstract": null, "doi": "10.1136/bmjgh-2022-009231", "pmid": "35613838", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2022-009231"}], "notes": [], "created": "2022-06-21T17:49:52.561Z", "modified": "2022-06-21T17:50:07.987Z"}, {"entity": "publication", "iuid": "3d935e59859c4024845fca7dd4df8caa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3d935e59859c4024845fca7dd4df8caa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3d935e59859c4024845fca7dd4df8caa"}}, "title": "Decidual stromal cell therapy for generalized lymphadenopathy as a special clinical manifestation of COVID-19 infection: A case report.", "authors": [{"family": "Pirsalehi", "given": "Ali", "initials": "A"}, {"family": "Soleimani", "given": "Masoud", "initials": "M"}, {"family": "Hajifathali", "given": "Abbas", "initials": "A"}, {"family": "Sadeghi", "given": "Behnam", "initials": "B"}, {"family": "Farhadihosseinabadi", "given": "Behrouz", "initials": "B"}, {"family": "Akhlaghi", "given": "Sedigheh Sadat", "initials": "SS"}, {"family": "Roshandel", "given": "Elham", "initials": "E", "orcid": "0000-0002-3698-4342", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e62f2dd66ca0485091e82ae8562d1505.json"}}], "type": "case reports", "published": "2022-05-00", "journal": {"title": "Clin Case Rep", "issn": "2050-0904", "volume": "10", "issue": "5", "pages": "e05851", "issn-l": null}, "abstract": "We are going through the greatest global health crisis of the last decades, the coronavirus disease 2019 (COVID-19) pandemic. It may cause morbidity and mortality in some cases, and there is no therapeutic approach with reproducible and favorable outcomes. As clinical manifestations differ from patient to patient, any report regarding clinical symptoms has been beneficial for early detection and treatment. Due to the immunomodulatory effect of mesenchymal stem cells (MSCs), MSCs-based therapy has been approved to be one of the therapeutic strategies for COVID-19 management. For the first time in the literature, we reported generalized lymphadenopathy with fever and no sign of respiratory distress in a 16-year-old patient with confirmed COVID-19 infection as the main clinical signs. We also introduce decidual stromal cells as a potential immunomodulatory treatment for COVID-19-infected patients.", "doi": "10.1002/ccr3.5851", "pmid": "35600010", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "CCR35851"}, {"db": "pmc", "key": "PMC9109646"}], "notes": [], "created": "2022-06-21T17:57:22.435Z", "modified": "2022-06-21T17:57:41.697Z"}, {"entity": "publication", "iuid": "8826996b9bfa4f1cb9689c5f1a4bd6b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8826996b9bfa4f1cb9689c5f1a4bd6b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8826996b9bfa4f1cb9689c5f1a4bd6b1"}}, "title": "Critical Influenza and COVID-19-A Comparative Nationwide Case-Control Study.", "authors": [{"family": "Larsson", "given": "Emma", "initials": "E"}, {"family": "Eriksson", "given": "Jesper", "initials": "J"}, {"family": "Eriksson", "given": "Mikael", "initials": "M"}, {"family": "Oldner", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "Crit Care Explor", "issn": "2639-8028", "volume": "4", "issue": "5", "pages": "e0705", "issn-l": null}, "abstract": "Refined knowledge of risk factors for critical influenza and COVID-19 may lead to improved understanding of pathophysiology and better pandemic preparedness.\n\nTo compare risk-factor profiles of patients admitted to intensive care with critical influenza and COVID-19.\n\nA nationwide retrospective matched case-control study, including all adults admitted to an ICU in Sweden with influenza or COVID-19 between 2014 and September 2020 and a matched control population (ratio 1:5, patients:controls).\n\nAdmission to an ICU. The study included 1,873 influenza and 2,567 COVID-19 ICU patients, and 9,365 and 12,835 controls, respectively, matched on sex, age, and geographical region. Influenza patients were older and less likely male, and carried a larger burden of comorbidity and a higher Simplified Acute Physiology Score III score, whereas short-term mortalities were similar when compared to COVID-19 patients. The risk-factor profiles at ICU admission were largely comparable including socioeconomic, psychiatric, and several somatic variables. Hypertension was a strong risk factor in critical COVID-19 patients compared with influenza. Nonglucocorticoid immunosuppressive therapy was associated with critical influenza but not COVID-19. Premorbid medication with statins and renin-angiotensin-aldosterone system inhibitors reduced the risk for both conditions, the opposite was a seen for glucocorticoid medication. Notably, medication with betablockers, oral anticoagulation, and platelet inhibitors reduced the risk of critical COVID-19 but not influenza.\n\nThe risk-factor profiles for critical influenza and COVID-19 were largely comparable; however, some important differences were noted. Hypertension was a stronger risk factor for developing critical COVID-19, whereas the use of betablockers, oral anticoagulants, and platelet inhibitors all reduced the risk of ICU admission for COVID-19 but not influenza. Findings possibly reflected differences in pathophysiological mechanisms between these conditions.", "doi": "10.1097/CCE.0000000000000705", "pmid": "35620773", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9113210"}], "notes": [], "created": "2022-06-21T17:46:41.918Z", "modified": "2022-06-21T17:46:54.296Z"}, {"entity": "publication", "iuid": "07b3875cd4054292815a8c4612d07501", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07b3875cd4054292815a8c4612d07501.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07b3875cd4054292815a8c4612d07501"}}, "title": "Convulsions in children with COVID-19 during the Omicron wave.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF", "orcid": "0000-0003-1024-5602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1d5e45881a7469ca20a0eb360d891cc.json"}}], "type": "case reports", "published": "2022-05-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": "111", "issue": "5", "pages": "1023-1026"}, "abstract": "Most children with COVID-19 have mild symptoms, but data on the Omicron variant are rare. This paper describes unexpected cases with convulsions during 1 week in January 2022.\n\nFour children with COVID-19 were admitted with convulsions to the paediatric department in \u00d6rebro, Sweden, when Omicron accounted for more than 98% of the country's COVID-19 cases. Three children tested positive for the virus, and one had clinical COVID-19. I was able to contact the parents of three boys, who gave consent for these case studies.\n\nTwo boys aged 3 and 21 months tested positive for the virus and a 14-year-old boy tested negative, but had a cold and family members who had tested positive. The teenager had a history of urinary tract infections, but the younger boys had no earlier comorbidities. None had a history of epilepsy or febrile convulsions. The younger children had a fever and the teenager had upper respiratory symptoms. The 3-month-old child had repeated convulsions for several hours, the 21-month-old had continuous convulsions for 15-20 min, and the teenager had a convulsion for 30-60 s, followed by uncharacteristic aggression.\n\nConvulsions may be a sign of the Omicron variant in children with COVID-19.", "doi": "10.1111/apa.16276", "pmid": "35098577", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Omicron VoC": null}, "xrefs": [{"db": "pmc", "key": "PMC9303202"}], "notes": [], "created": "2022-02-06T16:55:21.106Z", "modified": "2023-07-13T11:26:25.599Z"}, {"entity": "publication", "iuid": "4401467d26b944ba942c0ca2330ebac6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4401467d26b944ba942c0ca2330ebac6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4401467d26b944ba942c0ca2330ebac6"}}, "title": "Clinically observed deletions in SARS-CoV-2 Nsp1 affect its stability and ability to inhibit translation.", "authors": [{"family": "Kumar", "given": "Pravin", "initials": "P"}, {"family": "Schexnaydre", "given": "Erin", "initials": "E"}, {"family": "Rafie", "given": "Karim", "initials": "K"}, {"family": "Kurata", "given": "Tatsuaki", "initials": "T"}, {"family": "Terenin", "given": "Ilya", "initials": "I"}, {"family": "Hauryliuk", "given": "Vasili", "initials": "V", "orcid": "0000-0003-2389-5057", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1c92042b0bf4268a03534211e245236.json"}}, {"family": "Carlson", "given": "Lars-Anders", "initials": "LA", "orcid": "0000-0003-2342-6488", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79dd613daf254b33af16fafe01bf767c.json"}}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "FEBS Lett", "issn": "1873-3468", "volume": "596", "issue": "9", "pages": "1203-1213", "issn-l": null}, "abstract": "Nonstructural protein 1 (Nsp1) of SARS-CoV-2 inhibits host cell translation through an interaction between its C-terminal domain and the 40S ribosome. The N-terminal domain (NTD) of Nsp1 is a target of recurring deletions, some of which are associated with altered COVID-19 disease progression. Here, we characterize the efficiency of translational inhibition by clinically observed Nsp1 deletion variants. We show that a frequent deletion of residues 79-89 severely reduces the ability of Nsp1 to inhibit translation while not abrogating Nsp1 binding to the 40S. Notably, while the SARS-CoV-2 5' untranslated region enhances translation of mRNA, it does not protect from Nsp1-mediated inhibition. Finally, thermal stability measurements and structure predictions reveal a correlation between stability of the NTD and the efficiency of translation inhibition.", "doi": "10.1002/1873-3468.14354", "pmid": "35434785", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9081967"}], "notes": [], "created": "2022-10-13T12:59:32.403Z", "modified": "2022-10-13T12:59:32.530Z"}, {"entity": "publication", "iuid": "36edc1be7141435f9e1be136f7a7c17d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/36edc1be7141435f9e1be136f7a7c17d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/36edc1be7141435f9e1be136f7a7c17d"}}, "title": "Changes in Maternal Substance Use During the COVID-19 Pandemic.", "authors": [{"family": "Joyce", "given": "Kayla M", "initials": "KM"}, {"family": "Cameron", "given": "Emily E", "initials": "EE"}, {"family": "Sulymka", "given": "Julia", "initials": "J"}, {"family": "Protudjer", "given": "Jennifer L P", "initials": "JLP"}, {"family": "Roos", "given": "Leslie E", "initials": "LE"}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "J Stud Alcohol Drugs", "issn": "1938-4114", "volume": "83", "issue": "3", "pages": "352-357", "issn-l": null}, "abstract": "Maternal stress and mental health challenges have increased since the coronavirus disease 2019 (COVID-19) pandemic began. Experts are concerned about elevated substance use given its well-known association with negative emotions, but existing research has not examined substance use among mothers during the COVID-19 pandemic. This is a crucial next step to inform policy and service supports given links between maternal substance use and adverse family experiences.\n\nData were collected online between April 14 and 28, 2020. A total of 508 mothers (mean age = 34.8 years, SD = 5.1) with children 0-8 years old participated via the Parenting During the Pandemic study. Mothers self-reported substance use change and motivations for using substances, as well as mental health symptoms.\n\nOf participating mothers, 54.9% did not change, 39.2% increased, and 5.9% decreased their substance use. Findings indicated that mothers with an anxiety disorder or elevated anxiety symptoms were more likely to report increased substance use during the pandemic. Using substances to cope with anxiety, depression, and boredom was elevated among mothers self-reporting increased substance use during the pandemic versus those reporting no change or a decrease in usage. Using substances to cope with anxiety was a risk factor for increased substance use.\n\nMany mothers have increased their substance use since the onset of the COVID-19 pandemic. Results highlight the need to treat maternal anxiety and the importance of teaching mothers coping strategies, other than using substances, to reduce the incidence of increased substance use among mothers and its negative sequelae.", "doi": null, "pmid": "35590175", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-06-21T18:00:17.710Z", "modified": "2022-06-21T18:00:17.751Z"}, {"entity": "publication", "iuid": "2178f25932ef44ab8a94a9230fac5ac3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2178f25932ef44ab8a94a9230fac5ac3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2178f25932ef44ab8a94a9230fac5ac3"}}, "title": "Cardiac dysfunction and mortality in critically ill patients with COVID-19: A Swedish multicentre observational study.", "authors": [{"family": "Holmqvist", "given": "Jacob", "initials": "J"}, {"family": "Beck-Friis", "given": "Josefine", "initials": "J", "orcid": "0000-0003-2400-4092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3f3764c8d95410abc83f9c3cca2eaeb.json"}}, {"family": "Jensen", "given": "Carl", "initials": "C"}, {"family": "Dalla", "given": "Keti", "initials": "K", "orcid": "0000-0001-7367-2500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f1c43bc04bf49a7adc3559aa5deb916.json"}}, {"family": "M\u00e5rdstam", "given": "Simon", "initials": "S"}, {"family": "Christensen", "given": "Jens", "initials": "J"}, {"family": "Nord\u00e9n", "given": "Nina", "initials": "N"}, {"family": "Widing", "given": "Hannes", "initials": "H"}, {"family": "Ros\u00e9n-Wetterholm", "given": "Elin", "initials": "E"}, {"family": "Cavefors", "given": "Oscar", "initials": "O"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Redfors", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Oras", "given": "Jonatan", "initials": "J", "orcid": "0000-0001-8890-6752", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bcac0f5ee544c18ba18e949ce76d121.json"}}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "volume": "66", "issue": "5", "pages": "606-614", "issn-l": "0001-5172"}, "abstract": "The prevalence and importance of cardiac dysfunction in critically ill patients with COVID-19 in Sweden is not yet established. The aim of the study was to assess the prevalence of cardiac dysfunction and elevated pulmonary artery pressure (PAP), and its influence on mortality in patients with COVID-19 in intensive care in Sweden.\n\nThis was a multicentre observational study performed in five intensive care units (ICUs) in Sweden. Patients admitted to participating ICU with COVID-19 were examined with echocardiography within 72 h from admission and again after 4 to 7 days. Cardiac dysfunction was defined as left ventricular (LV) dysfunction (ejection fraction <50% and/or regional hypokinesia) or right ventricular (RV) dysfunction (defined as TAPSE <17 mm or visually assessed moderate/severe RV dysfunction).\n\nWe included 132 patients, of whom 127 (96%) were intubated. Cardiac dysfunction was found in 42 (32%) patients. Most patients had cardiac dysfunction at the first assessment (n = 35) while a few developed cardiac dysfunction later (n = 7) and some changed type of dysfunction (n = 3). LV dysfunction was found in 21 and RV dysfunction in 19 patients, while 5 patients had combined dysfunction. Elevated PAP was found in 34 patients (26%) and was more common in patients with RV dysfunction. RV dysfunction and elevated PAP were independently associated with an increased risk of death (OR 3.98, p = .013 and OR 3.88, p = .007, respectively).\n\nCardiac dysfunction occurs commonly in critically ill patients with COVID-19 in Sweden. RV dysfunction and elevated PAP are associated with an increased risk of death.", "doi": "10.1111/aas.14039", "pmid": "35122232", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9111275"}], "notes": [], "created": "2022-02-06T16:45:14.911Z", "modified": "2023-06-19T14:21:31.581Z"}, {"entity": "publication", "iuid": "7f77851d69024d19b295883953bc730d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f77851d69024d19b295883953bc730d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f77851d69024d19b295883953bc730d"}}, "title": "Acute COVID-19 severity and mental health morbidity trajectories in patient populations of six nations: an observational study.", "authors": [{"family": "Magn\u00fasd\u00f3ttir", "given": "Ingibj\u00f6rg", "initials": "I"}, {"family": "Lovik", "given": "Anik\u00f3", "initials": "A"}, {"family": "Unnarsd\u00f3ttir", "given": "Anna B\u00e1ra", "initials": "AB"}, {"family": "McCartney", "given": "Daniel", "initials": "D"}, {"family": "Ask", "given": "Helga", "initials": "H"}, {"family": "K\u00f5iv", "given": "Kadri", "initials": "K"}, {"family": "Christoffersen", "given": "Lea Arregui Nordahl", "initials": "LAN"}, {"family": "Johnson", "given": "Sverre Urnes", "initials": "SU"}, {"family": "Hauksd\u00f3ttir", "given": "Arna", "initials": "A"}, {"family": "Fawns-Ritchie", "given": "Chloe", "initials": "C"}, {"family": "Helenius", "given": "Dorte", "initials": "D"}, {"family": "Gonz\u00e1lez-Hij\u00f3n", "given": "Juan", "initials": "J"}, {"family": "Lu", "given": "Li", "initials": "L"}, {"family": "Ebrahimi", "given": "Omid V", "initials": "OV"}, {"family": "Hoffart", "given": "Asle", "initials": "A"}, {"family": "Porteous", "given": "David J", "initials": "DJ"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Jakobsd\u00f3ttir", "given": "J\u00f3hanna", "initials": "J"}, {"family": "Lehto", "given": "Kelli", "initials": "K"}, {"family": "Andreassen", "given": "Ole A", "initials": "OA"}, {"family": "Pedersen", "given": "Ole B V", "initials": "OBV"}, {"family": "Aspelund", "given": "Thor", "initials": "T"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur Anna", "initials": "UA"}, {"family": "COVIDMENT Collaboration", "given": "", "initials": ""}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "Lancet Public Health", "issn": "2468-2667", "volume": "7", "issue": "5", "pages": "e406-e416", "issn-l": null}, "abstract": "Long-term mental and physical health consequences of COVID-19 (long COVID) are a persistent public health concern. Little is still known about the long-term mental health of non-hospitalised patients with COVID-19 with varying illness severities. Our aim was to assess the prevalence of adverse mental health symptoms among individuals diagnosed with COVID-19 in the general population by acute infection severity up to 16 months after diagnosis.\n\nThis observational follow-up study included seven prospectively planned cohorts across six countries (Denmark, Estonia, Iceland, Norway, Sweden, and the UK). Participants were recruited from March 27, 2020, to Aug 13, 2021. Individuals aged 18 years or older were eligible to participate. In a cross-sectional analysis, we contrasted symptom prevalence of depression, anxiety, COVID-19-related distress, and poor sleep quality (screened with validated mental health instruments) among individuals with and without a diagnosis of COVID-19 at entry, 0-16 months from diagnosis. In a cohort analysis, we further used repeated measures to estimate the change in mental health symptoms before and after COVID-19 diagnosis.\n\nThe analytical cohort consisted of 247 249 individuals, 9979 (4\u00b70%) of whom were diagnosed with COVID-19 during the study period. Mean follow-up was 5\u00b765 months (SD 4\u00b726). Participants diagnosed with COVID-19 presented overall with a higher prevalence of symptoms of depression (prevalence ratio [PR] 1\u00b718 [95% CI 1\u00b703-1\u00b736]) and poorer sleep quality (1\u00b713 [1\u00b703-1\u00b724]) but not symptoms of anxiety (0\u00b797 [0\u00b791-1\u00b703]) or COVID-19-related distress (1\u00b705 [0\u00b793-1\u00b720]) compared with individuals without a COVID-19 diagnosis. Although the prevalence of depression and COVID-19-related distress attenuated with time, individuals diagnosed with COVID-19 but never bedridden due to their illness were consistently at lower risk of depression (PR 0\u00b783 [95% CI 0\u00b775-0\u00b791]) and anxiety (0\u00b777 [0\u00b763-0\u00b794]) than those not diagnosed with COVID-19, whereas patients who were bedridden for more than 7 days were persistently at higher risk of symptoms of depression (PR 1\u00b761 [95% CI 1\u00b727-2\u00b705]) and anxiety (1\u00b743 [1\u00b726-1\u00b763]) than those not diagnosed throughout the study period.\n\nSevere acute COVID-19 illness-indicated by extended time bedridden-is associated with long-term mental morbidity among recovering individuals in the general population. These findings call for increased vigilance of adverse mental health development among patients with a severe acute disease phase of COVID-19.\n\nNordforsk, Horizon2020, Wellcome Trust, and Estonian Research Council.", "doi": "10.1016/S2468-2667(22)00042-1", "pmid": "35298894", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8920517"}, {"db": "pii", "key": "S2468-2667(22)00042-1"}], "notes": [], "created": "2023-02-13T18:38:15.520Z", "modified": "2023-02-13T18:38:15.523Z"}, {"entity": "publication", "iuid": "63501e894e164b0bbdb771e6aed8e8cd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63501e894e164b0bbdb771e6aed8e8cd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63501e894e164b0bbdb771e6aed8e8cd"}}, "title": "Changes in dementia diagnoses in Sweden during the COVID-19 pandemic.", "authors": [{"family": "Axenhus", "given": "Michael", "initials": "M"}, {"family": "Schedin-Weiss", "given": "Sophia", "initials": "S"}, {"family": "Tjernberg", "given": "Lars", "initials": "L"}, {"family": "Wimo", "given": "Anders", "initials": "A"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}, {"family": "Bucht", "given": "Gustaf", "initials": "G"}, {"family": "Winblad", "given": "Bengt", "initials": "B"}], "type": "journal article", "published": "2022-04-26", "journal": {"title": "BMC Geriatr", "issn": "1471-2318", "volume": "22", "issue": "1", "pages": "365", "issn-l": null}, "abstract": "The COVID-19 pandemic has caused large disruptions to healthcare systems. Refocus on COVID-19 related care might have contributed to indirect effects on other healthcare areas. Care focused on acute conditions have been negatively affected although research into the effects on chronic and care intensive patient groups such as patients with dementia diseases is lacking. In this study we evaluated dementia diagnosis trends in Sweden during 2015-2020 according to International Classification of Disease version 10 coding of common dementia diseases.\n\nRegional and national statistics in the form of International Classification of Disease version 10 coding, COVID-19 incidence, mortality data, and population census data were collected from the National Institute of Health and Welfare. Logistic regression analysis was performed to identify trends of dementia diagnosis during 2015-2020. Correlation test was performed between COVID-19 incidence, mortality rates, and dementia coding.\n\nDementia diagnosis incidence has been declining since 2015 and further decline was noted in many regions in Sweden during 2020. As COVID-19 incidence increased, fewer cases of dementia were diagnosed, a decrease that differentially impacted women and those who were advanced in age.\n\nDementia diagnosis incidence in Sweden has been on a decline since 2015. The COVID-19 pandemic caused a further larger decline in dementia diagnosis incidence during 2020. COVID-19 incidence, but not mortality, was associated with decrease in dementia diagnosis incidence. There might be a large number of undiagnosed patients with dementia and healthcare reforms should be enacted to address this. Women and elderly are particularly vulnerable groups.", "doi": "10.1186/s12877-022-03070-y", "pmid": "35473668", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9039601"}, {"db": "pii", "key": "10.1186/s12877-022-03070-y"}], "notes": [], "created": "2023-01-13T13:24:16.248Z", "modified": "2023-07-13T11:28:31.916Z"}, {"entity": "publication", "iuid": "07a7aba3e7594af8a3d7070d543d7b60", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07a7aba3e7594af8a3d7070d543d7b60.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07a7aba3e7594af8a3d7070d543d7b60"}}, "title": "Characterization of the Upper Respiratory Bacterial Microbiome in Critically Ill COVID-19 Patients.", "authors": [{"family": "Bai", "given": "Xiangning", "initials": "X"}, {"family": "Narayanan", "given": "Aswathy", "initials": "A"}, {"family": "Skagerberg", "given": "Magdalena", "initials": "M"}, {"family": "Ce\u00f1a-Diez", "given": "Rafael", "initials": "R", "orcid": "0000-0001-9987-395X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dd115af211249249702e843a35ca885.json"}}, {"family": "Giske", "given": "Christian G", "initials": "CG"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2022-04-23", "journal": {"title": "Biomedicines", "issn": "2227-9059", "volume": "10", "issue": "5", "issn-l": null}, "abstract": "The upper respiratory tract (URT) microbiome can contribute to the acquisition and severity of respiratory viral infections. The described associations between URT microbiota and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are limited at microbiota genus level and by the lack of functional interpretation. Our study, therefore, characterized the URT bacterial microbiome at species level and their encoded pathways in patients with COVID-19 and correlated these to clinical outcomes. Whole metagenome sequencing was performed on nasopharyngeal samples from hospitalized patients with critical COVID-19 (n = 37) and SARS-CoV-2-negative individuals (n = 20). Decreased bacterial diversity, a reduction in commensal bacteria, and high abundance of pathogenic bacteria were observed in patients compared to negative controls. Several bacterial species and metabolic pathways were associated with better respiratory status and lower inflammation. Strong correlations were found between species biomarkers and metabolic pathways associated with better clinical outcome, especially Moraxella lincolnii and pathways of vitamin K2 biosynthesis. Our study demonstrates correlations between the URT microbiome and COVID-19 patient outcomes; further studies are warranted to validate these findings and to explore the causal roles of the identified microbiome biomarkers in COVID-19 pathogenesis.", "doi": "10.3390/biomedicines10050982", "pmid": "35625719", "labels": {"Type: Journal article": null, "Category: Health": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "biomedicines10050982"}], "notes": [], "created": "2022-06-21T17:41:02.435Z", "modified": "2022-06-21T17:42:47.714Z"}, {"entity": "publication", "iuid": "0ec5c2cac37d43749d6f318b8a2c95a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ec5c2cac37d43749d6f318b8a2c95a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ec5c2cac37d43749d6f318b8a2c95a0"}}, "title": "Impact of Long COVID on health and quality of life.", "authors": [{"family": "O' Mahony", "given": "Liam", "initials": "L", "orcid": "0000-0003-4705-3583", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff1b8e3e2a0740c2b80dfc33eb95918c.json"}}, {"family": "Buwalda", "given": "Tanja", "initials": "T", "orcid": "0000-0003-1759-1348", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f77991bf89546659fcad40626ce0337.json"}}, {"family": "Blair", "given": "Matthew", "initials": "M"}, {"family": "Forde", "given": "Brian", "initials": "B"}, {"family": "Lunjani", "given": "Nonhlanhla", "initials": "N"}, {"family": "Ambikan", "given": "Anoop", "initials": "A"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U", "orcid": "0000-0002-0844-3338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5c27a627463945d992d74005f8a60d88.json"}}, {"family": "Barrett", "given": "Peter", "initials": "P", "orcid": "0000-0002-9637-9603", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae6be9f9cf2742c1a5ac01083e07d287.json"}}, {"family": "Geary", "given": "Eoin", "initials": "E"}, {"family": "O'Connor", "given": "Nuala", "initials": "N"}, {"family": "Dineen", "given": "Jennifer", "initials": "J"}, {"family": "Clarke", "given": "Gerard", "initials": "G"}, {"family": "Kelleher", "given": "Eric", "initials": "E"}, {"family": "Horgan", "given": "Mary", "initials": "M"}, {"family": "Jackson", "given": "Arthur", "initials": "A"}, {"family": "Sadlier", "given": "Corinna", "initials": "C", "orcid": "0000-0002-8415-2022", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/036863e36b4d4480b10efc5e1cd8a025.json"}}], "type": "journal article", "published": "2022-04-22", "journal": {"title": "HRB Open Res", "issn": "2515-4826", "volume": "5", "pages": "31", "issn-l": null}, "abstract": "Background: The aim of this study was to measure the impact of post-acute sequelae of COVID-19 (PASC) on quality of life, mental health, ability to work and return to baseline health in an Irish cohort. Methods: We invited individuals with symptoms of COVID-19 lasting more than 14 days to participate in an anonymous online questionnaire. Basic demographic data and self-reported symptoms were recorded. Internationally validated instruments including the patient health questionnaire somatic, anxiety and depressive symptom scales (PHQ-SADS), the Patient Health Questionnaire-15 (PHQ-15) and Chadler fatigue scale (CFQ) were used. Results: We analysed responses from 988 participants with self-reported confirmed (diagnostic/antibody positive; 81%) or suspected (diagnostic/antibody negative or untested; 9%) COVID-19. The majority of respondents were female (88%), white (98%), with a median age of 43.0 (range 15 - 88 years old) and a median BMI of 26.0 (range 16 - 60). At the time of completing this survey, 89% of respondents reported that they have not returned to their pre-COVID-19 level of health. The median number of symptoms reported was 8 (range 0 to 33 symptoms), with a median duration of 12 months (range 1 to 20 months) since time of acute infection. A high proportion of PASC patients reported that they have a moderate or severe limitation in their ability to carry out their usual activities, 38% report their ability to work is severely limited and 33% report a moderate, or higher, level of anxiety or depression. Conclusion: The results of this survey of an Irish cohort with PASC are in line with reports from other settings, and we confirm that patients with PASC reported prolonged, multi-system symptoms which can significantly impact quality of life, affect ability to work and cause significant disability. Dedicated multidisciplinary, cross specialty supports are required to improve outcomes of this patient group.", "doi": "10.12688/hrbopenres.13516.1", "pmid": "36101871", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9440374"}, {"db": "figshare", "key": "10.6084/m9.figshare.19364828.v1"}], "notes": [], "created": "2022-10-13T13:30:19.780Z", "modified": "2022-10-13T13:30:19.933Z"}, {"entity": "publication", "iuid": "4b983ed275bb4432b5d9c6b0caa293f5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b983ed275bb4432b5d9c6b0caa293f5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b983ed275bb4432b5d9c6b0caa293f5"}}, "title": "App-based COVID-19 syndromic surveillance and prediction of hospital admissions in COVID Symptom Study Sweden.", "authors": [{"family": "Kennedy", "given": "Beatrice", "initials": "B", "orcid": "0000-0002-0066-4814", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d3a346caa424c4dad653097b2518efb.json"}}, {"family": "Fitipaldi", "given": "Hugo", "initials": "H", "orcid": "0000-0001-5352-2134", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3dc5e2fbac6748eaa733dc8ee1abdfa8.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U"}, {"family": "Maziarz", "given": "Marlena", "initials": "M", "orcid": "0000-0003-1417-6050", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89782e93a17a4b44a89ad63cd80cce7f.json"}}, {"family": "Tsereteli", "given": "Neli", "initials": "N"}, {"family": "Oskolkov", "given": "Nikolay", "initials": "N", "orcid": "0000-0001-5326-8893", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c7eace8c27946a0b98ef5fcba466b0d.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G", "orcid": "0000-0002-3320-2448", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73494da542e8482694f425eb2de5d52d.json"}}, {"family": "Franks", "given": "Camilla A", "initials": "CA"}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c29a5a2d88b0407ba2e3d62baffffa3e.json"}}, {"family": "Spiliopoulos", "given": "Lampros", "initials": "L"}, {"family": "Adami", "given": "Hans-Olov", "initials": "HO", "orcid": "0000-0001-9592-5791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba3e4202c4be46ed9a2836ba631dce1e.json"}}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J", "orcid": "0000-0003-1883-2000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e88fdca336ae41c891f0a46e2481b67f.json"}}, {"family": "Engblom", "given": "Stefan", "initials": "S", "orcid": "0000-0002-3614-1732", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2d5c78e143c44eba2f0e8b463cefc5d.json"}}, {"family": "Fall", "given": "Katja", "initials": "K", "orcid": "0000-0002-3649-2639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa0adf9b952e4e998c4a2deb07be5907.json"}}, {"family": "Grimby-Ekman", "given": "Anna", "initials": "A", "orcid": "0000-0002-9408-6065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c55950a9f1f4f868363a84975157fe4.json"}}, {"family": "Litton", "given": "Jan-Eric", "initials": "JE"}, {"family": "Martinell", "given": "Mats", "initials": "M"}, {"family": "Oudin", "given": "Anna", "initials": "A", "orcid": "0000-0002-9876-0627", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46d26c6a20434968a730560fb7b160a2.json"}}, {"family": "Sj\u00f6str\u00f6m", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Timpka", "given": "Toomas", "initials": "T", "orcid": "0000-0001-6049-5402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebcb4fac20f845a4bd9eaa4bf1660ebb.json"}}, {"family": "Sudre", "given": "Carole H", "initials": "CH", "orcid": "0000-0001-5753-428X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c26472813fed4007a8757af771de1802.json"}}, {"family": "Graham", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-4170-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f5f4e19812a46ed9e873732ec25e28d.json"}}, {"family": "du Cadet", "given": "Julien Lavigne", "initials": "JL"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "Davies", "given": "Richard", "initials": "R", "orcid": "0000-0003-2050-3994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b82cc92615f462d9af0153a6fb94fde.json"}}, {"family": "Ganesh", "given": "Sajaysurya", "initials": "S"}, {"family": "May", "given": "Anna", "initials": "A"}, {"family": "Ourselin", "given": "S\u00e9bastien", "initials": "S", "orcid": "0000-0002-5694-5340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74c7b9b1633144879042d198c7205656.json"}}, {"family": "Pujol", "given": "Joan Capdevila", "initials": "JC"}, {"family": "Selvachandran", "given": "Somesh", "initials": "S"}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}, {"family": "Gomez", "given": "Maria F", "initials": "MF", "orcid": "0000-0001-6210-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e09e37219c4f42c8a7b3a982da523859.json"}}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74cf1f7094744ee289fa5df041e7cb5b.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f34c0d3602439abe6096293c7c732d.json"}}], "type": "journal article", "published": "2022-04-21", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "13", "issue": "1", "pages": "2110"}, "abstract": "The app-based COVID Symptom Study was launched in Sweden in April 2020 to contribute to real-time COVID-19 surveillance. We enrolled 143,531 study participants (\u226518 years) who contributed 10.6 million daily symptom reports between April 29, 2020 and February 10, 2021. Here, we include data from 19,161 self-reported PCR tests to create a symptom-based model to estimate the individual probability of symptomatic COVID-19, with an AUC of 0.78 (95% CI 0.74-0.83) in an external dataset. These individual probabilities are employed to estimate daily regional COVID-19 prevalence, which are in turn used together with current hospital data to predict next week COVID-19 hospital admissions. We show that this hospital prediction model demonstrates a lower median absolute percentage error (MdAPE: 25.9%) across the five most populated regions in Sweden during the first pandemic wave than a model based on case notifications (MdAPE: 30.3%). During the second wave, the error rates are similar. When we apply the same model to an English dataset, not including local COVID-19 test data, we observe MdAPEs of 22.3% and 19.0% during the first and second pandemic waves, respectively, highlighting the transferability of the prediction model.", "doi": "10.1038/s41467-022-29608-7", "pmid": "35449172", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9023535"}, {"db": "pii", "key": "10.1038/s41467-022-29608-7"}], "notes": [], "created": "2021-06-23T07:15:51.852Z", "modified": "2023-01-13T13:31:54.600Z"}, {"entity": "publication", "iuid": "a6fbf67199f54aef93b69717f097602d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6fbf67199f54aef93b69717f097602d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6fbf67199f54aef93b69717f097602d"}}, "title": "Uncontrolled asthma predicts severe COVID-19: a report from the Swedish National Airway Register.", "authors": [{"family": "Karlsson Sundbaum", "given": "Johanna", "initials": "J", "orcid": "0000-0001-5313-7981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8b5dfbfb761446aa474013fcccdd085.json"}}, {"family": "Konradsen", "given": "Jon R", "initials": "JR"}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW"}, {"family": "Axelsson Fisk", "given": "Sten", "initials": "S"}, {"family": "Pedroletti", "given": "Christophe", "initials": "C"}, {"family": "Sj\u00f6\u00f6", "given": "Yvonne", "initials": "Y"}, {"family": "Syk", "given": "J\u00f6rgen", "initials": "J"}, {"family": "Sterner", "given": "Therese", "initials": "T"}, {"family": "Lindberg", "given": "Anne", "initials": "A"}, {"family": "Tuns\u00e4ter", "given": "Alf", "initials": "A"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ekberg-Jansson", "given": "Ann", "initials": "A"}, {"family": "Stridsman", "given": "Caroline", "initials": "C", "orcid": "0000-0001-6622-3838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e2fc66fb68748eba5a7f8eb93c5ff3f.json"}}], "type": "journal article", "published": "2022-04-19", "journal": {"title": "Ther Adv Respir Dis", "issn": "1753-4666", "issn-l": null, "volume": "16", "issue": null, "pages": "17534666221091183"}, "abstract": "Severe asthma increases the risk of severe COVID-19 outcomes such as hospitalization and death. However, more studies are needed to understand the association between asthma and severe COVID-19.\r\n\r\nA cohort of 150,430 adult asthma patients were identified in the Swedish National Airway Register (SNAR) from 2013 to December 2020. Data on body mass index, smoking habits, lung function, and asthma control test (ACT) were obtained from SNAR, and uncontrolled asthma was defined as ACT \u2a7d19. Patients with severe COVID-19 were identified following hospitalization or in death certificates based on ICD-10 codes U07.1 and U07.2. The Swedish Prescribed Drug register was used to identify comorbidities and data from Statistics Sweden for educational level. Multivariate logistic regression analyses were used to estimate associations with severe COVID-19.\r\n\r\nSevere COVID-19 was identified in 1067 patients (0.7%). Older age (OR = 1.04, 95% CI = 1.03-1.04), male sex (1.42, 1.25-1.61), overweight (1.56, 1.27-1.91), obesity (2.12, 1.73-2.60), high-dose inhaled corticosteroids in combination with long-acting \u03b2-agonists (1.40, 1.22-1.60), dispensed oral corticosteroids \u2a7e2 (1.48, 1.25-1.75), uncontrolled asthma (1.64, 1.35-2.00), cardiovascular disease (1.20, 1.03-1.40), depression (1.47, 1.28-1.68), and diabetes (1.52, 1.29-1.78) were associated with severe COVID-19, while current smoking was inversely associated (0.63, 0.47-0.85). When comparing patients who died from COVID-19 with those discharged alive from hospital until 31 December 2020, older age, male sex, and current smoking were associated with COVID-19 death.\r\n\r\nPatients with uncontrolled asthma and high disease burden, including increased asthma medication intensity, should be identified as risk patients for severe COVID-19. Furthermore, current smoking is strongly associated with COVID-19 death in asthma.", "doi": "10.1177/17534666221091183", "pmid": "35430944", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pmc", "key": "PMC9019327"}], "notes": [], "created": "2023-01-13T09:54:31.722Z", "modified": "2023-01-13T09:56:02.884Z"}, {"entity": "publication", "iuid": "17d4b6ebe48f4891bf1e5a56692d5e69", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/17d4b6ebe48f4891bf1e5a56692d5e69.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/17d4b6ebe48f4891bf1e5a56692d5e69"}}, "title": "The Evolution of Blood Cell Phenotypes, Intracellular and Plasma Cytokines and Morphological Changes in Critically Ill COVID-19 Patients.", "authors": [{"family": "Bergh\u00e4ll", "given": "Elisabeth", "initials": "E", "orcid": "0000-0002-3287-6504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6aacfcdf39b46daaa541c3123927ab6.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Hahn-Str\u00f6mberg", "given": "Victoria", "initials": "V"}], "type": "journal article", "published": "2022-04-19", "journal": {"title": "Biomedicines", "issn": "2227-9059", "issn-l": null, "volume": "10", "issue": "5", "pages": null}, "abstract": "Severe coronavirus disease 2019 (COVID-19) causes a strong inflammatory response. To obtain an overview of inflammatory mediators and effector cells, we studied 25 intensive-care-unit patients during the timeframe after off-label chloroquine treatment and before an introduction of immunomodulatory drugs.\r\n\r\nBlood samples were weekly examined with flow cytometry (FCM) for surface and intracytoplasmic markers, cytokine assays were analyzed for circulating interleukins (ILs), and blood smears were evaluated for morphological changes. Samples from healthy volunteers were used for comparison. Organ function data and 30-day mortality were obtained from medical records.\r\n\r\nCompared to that of the healthy control group, the expression levels of leukocyte surface markers, i.e., the cluster of differentiation (CD) markers CD2, CD4, CD8, CD158d, CD25, CD127, and CD19, were lower (p &lt; 0.001), while those of leukocytes expressing CD33 were increased (p &lt; 0.05). An aberrant expression of CD158d on granulocytes was found on parts of the granulocyte population. The expression levels of intracellular tumor necrosis factor alpha (TNF\u03b1) and IL-1 receptor type 2 in leukocytes were higher (p &lt; 0.001) as well as plasma levels of TNF\u03b1, IL-2, IL-6, IL-8, IL-10 (p &lt; 0.001), interferon gamma (IFN\u03b3) (p &lt; 0.01), and granulocyte-macrophage colony-stimulating factor (GM-CSF) (p &lt; 0.05). The expression levels of CD33+ leukocytes and circulating IL-6 were higher (p &lt; 0.05) among patients with arterial oxygen partial pressure-to-fractional inspired oxygen (PaO2/FiO2) ratios below 13.3 kPa compared to in the remaining patients. The expression levels of TNF\u03b1, IL-2, IL-4, IL-6, IL-8, and IL-10 were higher in patients treated with continuous renal replacement therapy (CRRT) (p &lt; 0.05), and the levels of the maximum plasma creatinine and TNF\u03b1 Spearman's rank-order correlation coefficient (rho = 0.51, p &lt; 0.05) and IL-8 (rho = 0.44, p &lt; 0.05) correlated. Blood smears revealed neutrophil dysplasia with pseudo-Pelger forms being most common.\r\n\r\nThese findings suggest that patients with severe COVID-19, in addition to augmented ILs, lymphopenia, and increased granulocytes, also had effects on the bone marrow.", "doi": "10.3390/biomedicines10050934", "pmid": "35625671", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "biomedicines10050934"}], "notes": [], "created": "2022-06-21T17:43:10.166Z", "modified": "2022-08-19T12:34:49.174Z"}, {"entity": "publication", "iuid": "811f1f490b264020b8b6e2c851d2ef83", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/811f1f490b264020b8b6e2c851d2ef83.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/811f1f490b264020b8b6e2c851d2ef83"}}, "title": "Dissecting the Molecular Mechanisms Surrounding Post-COVID-19 Syndrome and Neurological Features.", "authors": [{"family": "Mohamed", "given": "Mohamed S", "initials": "MS"}, {"family": "Johansson", "given": "Anton", "initials": "A"}, {"family": "Jonsson", "given": "J\u00f6rgen", "initials": "J"}, {"family": "Schi\u00f6th", "given": "Helgi B", "initials": "HB"}], "type": "journal article", "published": "2022-04-12", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "23", "issue": "8", "issn-l": null}, "abstract": "Many of the survivors of the novel coronavirus disease (COVID-19) are suffering from persistent symptoms, causing significant morbidity and decreasing their quality of life, termed \"post-COVID-19 syndrome\" or \"long COVID\". Understanding the mechanisms surrounding PCS is vital to developing the diagnosis, biomarkers, and possible treatments. Here, we describe the prevalence and manifestations of PCS, and similarities with previous SARS epidemics. Furthermore, we look at the molecular mechanisms behind the neurological features of PCS, where we highlight important neural mechanisms that may potentially be involved and pharmacologically targeted, such as glutamate reuptake in astrocytes, the role of NMDA receptors and transporters (EAAT2), ROS signaling, astrogliosis triggered by NF-\u03baB signaling, KNDy neurons, and hypothalamic networks involving Kiss1 (a ligand for the G-protein-coupled receptor 54 (GPR54)), among others. We highlight the possible role of reactive gliosis following SARS-CoV-2 CNS injury, as well as the potential role of the hypothalamus network in PCS manifestations.", "doi": "10.3390/ijms23084275", "pmid": "35457093", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC9028501"}, {"db": "pii", "key": "ijms23084275"}], "notes": [], "created": "2023-01-13T13:33:37.680Z", "modified": "2023-01-13T13:33:37.694Z"}, {"entity": "publication", "iuid": "55a6ebbc875e40729467c6ea2c76a8a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/55a6ebbc875e40729467c6ea2c76a8a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/55a6ebbc875e40729467c6ea2c76a8a6"}}, "title": "Specific T-cell responses for guiding treatment with convalescent plasma in severe COVID-19 and humoral immunodeficiency: a case report.", "authors": [{"family": "Nystr\u00f6m", "given": "Katarina", "initials": "K"}, {"family": "Hjorth", "given": "Maria", "initials": "M"}, {"family": "Fust", "given": "Ramona", "initials": "R"}, {"family": "Nilsdotter-Augustinsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Larsson", "given": "Marie", "initials": "M"}, {"family": "Niward", "given": "Katarina", "initials": "K"}, {"family": "Nystr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0002-0145-4966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56bc7bc8ab444c81afd336394ae7607d.json"}}], "type": "case reports", "published": "2022-04-11", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "volume": "22", "issue": "1", "pages": "362", "issn-l": null}, "abstract": "The immune response to SARS-CoV-2 virus, the cause of COVID-19, is complex. Antibody mediated responses are important for viral clearance but may also drive hyperinflammation in severe COVID-19. We present a case of an individual with a genetic inability to produce antibodies and severe COVID-19, receiving no other specific anti-viral treatment than convalescent COVID-19 plasma, illustrating that hyperinflammation can occur in the absence of a humoral anti-viral response. In addition, the case illustrates that the assessment of SARS-CoV-2 T cell responses can facilitate clinical decision making in patients with COVID-19 and weak or absent humoral immune responses.\n\nA male with X-linked agammaglobulinemia on regular immunoglobulin replacement therapy, hospitalized for 35 days due to severe COVID-19. Systemic inflammatory parameters were highly elevated. After treatment with convalescent COVID-19 plasma he became afebrile and the fatigue diminished. He was discharged on day 42 and nasopharyngeal SARS-CoV-2 PCR eventually was negative on day 49. Evidence of SARS-CoV-2 specific T cells prior to administration of plasma therapy suggested that antibodies were crucial for viral clearance. Regular assessment showed robust and persistent SARS-CoV-2 specific T-cell responses after recovery suggested that prophylactic administration of convalescent COVID-19 plasma was unnecessary.\n\nAssessment of SARS-CoV-2T-cell responses can facilitate the clinical management of COVID-19 patients with humoral immunodeficiencies.", "doi": "10.1186/s12879-022-07323-4", "pmid": "35410137", "labels": {"Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12879-022-07323-4"}, {"db": "pmc", "key": "PMC8996199"}], "notes": [], "created": "2022-10-13T13:01:08.111Z", "modified": "2022-10-13T13:01:08.145Z"}, {"entity": "publication", "iuid": "ed9f0221711e4437bea0df3752e4e0fe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed9f0221711e4437bea0df3752e4e0fe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed9f0221711e4437bea0df3752e4e0fe"}}, "title": "Impact of covid-19 on long-term oxygen therapy 2020: A nationwide study in Sweden.", "authors": [{"family": "Sundh", "given": "Josefin", "initials": "J", "orcid": "0000-0003-1926-8464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0994c494df3b4955bedb00606add70d6.json"}}, {"family": "Palm", "given": "Andreas", "initials": "A"}, {"family": "Wahlberg", "given": "Josefin", "initials": "J"}, {"family": "Runold", "given": "Michael", "initials": "M"}, {"family": "Ekstr\u00f6m", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2022-04-08", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "4", "pages": "e0266367", "issn-l": "1932-6203"}, "abstract": "Covid-19 can cause chronic hypoxic respiratory failure, but the impact on the need for long-term oxygen therapy (LTOT) is unknown. The aim was to investigate change in incidence and characteristics of patients starting LTOT in Sweden 2020 after the outbreak of the pandemic.\n\nPopulation-based observational study using data from the National Registry for Respiratory Failure (Swedevox) and from a survey to all centres prescribing LTOT in Sweden. Swedevox data provided information on incidence of LTOT and characteristics of patients starting LTOT during 2015-2020.\n\nBetween March-Dec 2020, 131 patients started LTOT due to covid-19, corresponding to 20.5% of incident LTOT in Sweden. Compared with 2015-19, the total number of patients starting LTOT did not increase. No significant differences in patient characteristics or underlying causes of hypoxemia were found between patients starting LTOT during 2020 compared 2015-2019. The majority of the LTOT centres estimated that, since the start of the pandemic, the incidence of LTOT was unchanged and the time devoted for LTOT work was the same or slightly less.\n\nCovid-19 caused one fifth of all LTOT starts during the pandemic in 2020. The LTOT incidence overall did not increase possibly due to reduction in other infections.", "doi": "10.1371/journal.pone.0266367", "pmid": "35395039", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8992997"}, {"db": "pii", "key": "PONE-D-21-37749"}], "notes": [], "created": "2023-01-13T13:41:15.466Z", "modified": "2023-01-13T13:41:15.492Z"}, {"entity": "publication", "iuid": "cc323c7ea5b948ddb0f5c9673daaaa59", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc323c7ea5b948ddb0f5c9673daaaa59.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc323c7ea5b948ddb0f5c9673daaaa59"}}, "title": "An olfactory self-test effectively screens for COVID-19.", "authors": [{"family": "Snitz", "given": "Kobi", "initials": "K"}, {"family": "Honigstein", "given": "Danielle", "initials": "D"}, {"family": "Weissgross", "given": "Reut", "initials": "R", "orcid": "0000-0002-6554-9462", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03bcaa7f65b342719a8e846b28c2b282.json"}}, {"family": "Ravia", "given": "Aharon", "initials": "A", "orcid": "0000-0003-2183-9254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3599c1d815e04e338fe4440fdc95be77.json"}}, {"family": "Mishor", "given": "Eva", "initials": "E", "orcid": "0000-0003-4006-3789", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2ede0162e8d4daf81350bacab4d7f9d.json"}}, {"family": "Perl", "given": "Ofer", "initials": "O"}, {"family": "Karagach", "given": "Shiri", "initials": "S"}, {"family": "Medhanie", "given": "Abebe", "initials": "A"}, {"family": "Harel", "given": "Nir", "initials": "N"}, {"family": "Shushan", "given": "Sagit", "initials": "S"}, {"family": "Roth", "given": "Yehudah", "initials": "Y"}, {"family": "Iravani", "given": "Behzad", "initials": "B", "orcid": "0000-0001-9905-1067", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5c799aeccef49a59531ad96984f466b.json"}}, {"family": "Arshamian", "given": "Artin", "initials": "A"}, {"family": "Ernst", "given": "Gernot", "initials": "G", "orcid": "0000-0001-5224-0338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/afb20633af994b808d8e6818812afa59.json"}}, {"family": "Okamoto", "given": "Masako", "initials": "M"}, {"family": "Poo", "given": "Cindy", "initials": "C"}, {"family": "Bonacchi", "given": "Niccol\u00f2", "initials": "N", "orcid": "0000-0001-5228-6918", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b985fa7a1f24d44bd254daba559c128.json"}}, {"family": "Mainen", "given": "Zachary", "initials": "Z", "orcid": "0000-0001-7913-9109", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a189fcf3c6d41f98339f08ebdf8244a.json"}}, {"family": "Monteleone", "given": "Erminio", "initials": "E"}, {"family": "Dinnella", "given": "Caterina", "initials": "C", "orcid": "0000-0002-5765-6057", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/315a95a9248c43dfb7ed2231824b6ced.json"}}, {"family": "Spinelli", "given": "Sara", "initials": "S"}, {"family": "Mari\u00f1o-S\u00e1nchez", "given": "Franklin", "initials": "F"}, {"family": "Ferdenzi", "given": "Camille", "initials": "C"}, {"family": "Smeets", "given": "Monique", "initials": "M"}, {"family": "Touhara", "given": "Kazushige", "initials": "K"}, {"family": "Bensafi", "given": "Moustafa", "initials": "M", "orcid": "0000-0002-2991-3036", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11b9f8b4dfbd4345ad03a0a694d5efcd.json"}}, {"family": "Hummel", "given": "Thomas", "initials": "T"}, {"family": "Lundstr\u00f6m", "given": "Johan N", "initials": "JN", "orcid": "0000-0002-3529-8981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a92f50aea024a1fbf0cfda979efef11.json"}}, {"family": "Sobel", "given": "Noam", "initials": "N", "orcid": "0000-0002-3232-9391", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34beac29a3ed4d169aa33d270f09d186.json"}}], "type": "journal article", "published": "2022-04-05", "journal": {"title": "Commun Med (Lond)", "issn": "2730-664X", "volume": "2", "pages": "34", "issn-l": null}, "abstract": "Key to curtailing the COVID-19 pandemic are wide-scale screening strategies. An ideal screen is one that would not rely on transporting, distributing, and collecting physical specimens. Given the olfactory impairment associated with COVID-19, we developed a perceptual measure of olfaction that relies on smelling household odorants and rating them online.\n\nEach participant was instructed to select 5 household items, and rate their perceived odor pleasantness and intensity using an online visual analogue scale. We used this data to assign an olfactory perceptual fingerprint, a value that reflects the perceived difference between odorants. We tested the performance of this real-time tool in a total of 13,484 participants (462 COVID-19 positive) from 134 countries who provided 178,820 perceptual ratings of 60 different household odorants.\n\nWe observe that olfactory ratings are indicative of COVID-19 status in a country, significantly correlating with national infection rates over time. More importantly, we observe indicative power at the individual level (79% sensitivity and 87% specificity). Critically, this olfactory screen remains effective in participants with COVID-19 but without symptoms, and in participants with symptoms but without COVID-19.\n\nThe current odorant-based olfactory screen adds a component to online symptom-checkers, to potentially provide an added first line of defense that can help fight disease progression at the population level. The data derived from this tool may allow better understanding of the link between COVID-19 and olfaction.", "doi": "10.1038/s43856-022-00095-7", "pmid": "35603293", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "95"}, {"db": "pmc", "key": "PMC9053292"}], "notes": [], "created": "2022-06-21T17:55:17.396Z", "modified": "2022-11-21T15:30:33.313Z"}, {"entity": "publication", "iuid": "049abad9f8c946609902e95615a648a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/049abad9f8c946609902e95615a648a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/049abad9f8c946609902e95615a648a6"}}, "title": "Impact of post-COVID conditions on mental health: a cross-sectional study in Japan and Sweden.", "authors": [{"family": "Matsumoto", "given": "Kazuki", "initials": "K"}, {"family": "Hamatani", "given": "Sayo", "initials": "S", "orcid": "0000-0001-7847-6381", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ed7722373ad4aed8a58e4ee130a925f.json"}}, {"family": "Shimizu", "given": "Eiji", "initials": "E"}, {"family": "K\u00e4ll", "given": "Anton", "initials": "A"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}], "type": "journal article", "published": "2022-04-04", "journal": {"title": "BMC Psychiatry", "issn": "1471-244X", "volume": "22", "issue": "1", "pages": "237", "issn-l": null}, "abstract": "Due to the coronavirus disease 2019 (COVID-19) pandemic, people have undermined their mental health. It has been reported that post-COVID conditions at a certain rate. However, information on the mental health of people with post-COVID conditions is limited. Thus, this study investigated the relationship between post-COVID conditions and mental health.\n\nDesign of the present study was an International and collaborative cross-sectional study in Japan and Sweden from March 18 to June 15, 2021. The analyzed data included 763 adults who participated in online surveys in Japan and Sweden and submitted complete data. In addition to demographic data including terms related to COVID-19, psychiatric symptoms such as depression, anxiety, and post-traumatic stress were measured by using the fear of COVID-19 scale (FCV-19S), Patient Health Questionnaire-9 (PHQ-9), General Anxiety Disorder-7 item (GAD-7), and Impact of Event Scale-Revised (IES-R).\n\nOf the 135 COVID-19 survivors among the 763 total participants, 37.0% (n = 50/135) had COVID-19-related sequelae. First, the results of the Bonferroni-corrected Mann Whitney U test showed that the group infected SARS-CoV-2 with post-COVID conditions scored significantly higher than those without one and the non-infected group on all clinical symptom scales (P \u2264 .05). Next, there was a significant difference that incidence rates of clinical-significant psychiatric symptoms among each group from the results of the Chi-squared test (P \u2264 .001). Finally, the results of the multivariate logistic model revealed that the risk of having more severe clinical symptoms were 2.44-3.48 times higher among participants with post-COVID conditions.\n\nThe results showed that approximately half had some physical symptoms after COVID-19 and that post-COVID conditions may lead to the onset of mental disorders.\n\nThe ethics committee of Chiba University approved this cross-sectional study (approval number: 4129). However, as no medical intervention was conducted, a clinical trial registration was not necessary.", "doi": "10.1186/s12888-022-03874-7", "pmid": "35379224", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8977559"}, {"db": "pii", "key": "10.1186/s12888-022-03874-7"}], "notes": [], "created": "2023-01-13T13:40:33.923Z", "modified": "2023-01-13T13:40:33.970Z"}, {"entity": "publication", "iuid": "1dd2f6a205d9420394113cfef0c78c22", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1dd2f6a205d9420394113cfef0c78c22.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1dd2f6a205d9420394113cfef0c78c22"}}, "title": "COVID-19 IDD: Findings from a global survey exploring family members' and paid staff's perceptions of the impact of COVID-19 on individuals with intellectual and developmental disabilities (IDD) and their caregivers.", "authors": [{"family": "Linehan", "given": "Christine", "initials": "C", "orcid": "0000-0002-9083-3457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b2eec9989c3470fb49471050007ea84.json"}}, {"family": "Birkbeck", "given": "Gail", "initials": "G"}, {"family": "Araten-Bergman", "given": "Tal", "initials": "T", "orcid": "0000-0003-4915-2729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aaffeee537eb4a27b785d4e4db4134c6.json"}}, {"family": "Baumbusch", "given": "Jennifer", "initials": "J"}, {"family": "Beadle-Brown", "given": "Julie", "initials": "J"}, {"family": "Bigby", "given": "Christine", "initials": "C", "orcid": "0000-0001-7001-8976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb03eecfdf5748ccadd49117bea5b00b.json"}}, {"family": "Bradley", "given": "Valerie", "initials": "V"}, {"family": "Brown", "given": "Michael", "initials": "M", "orcid": "0000-0003-3230-401X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34355c671e7b491cbd5b76429680aad3.json"}}, {"family": "Bredewold", "given": "Femmianne", "initials": "F", "orcid": "0000-0002-6231-8263", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7dca30eb8e3f487fb8f7f1bf67d44ed5.json"}}, {"family": "Chirwa", "given": "Masauso", "initials": "M", "orcid": "0000-0002-6293-5034", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f99b5be63ea94917a122bba4751e0168.json"}}, {"family": "Cui", "given": "Jialiang", "initials": "J", "orcid": "0000-0001-8708-1947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/393d73a952544ea28655eb9073fe42b1.json"}}, {"family": "Godoy Gimenez", "given": "Marta", "initials": "M"}, {"family": "Gomeiro", "given": "Tiziano", "initials": "T", "orcid": "0000-0002-2931-9571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74a9af063b354d07bf09cd1f73dac2de.json"}}, {"family": "Kanova", "given": "\u0160\u00e1rka", "initials": "\u0160", "orcid": "0000-0003-0846-5737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19dc6d08bfa648feba2d4d0fa83b6dca.json"}}, {"family": "Kroll", "given": "Thilo", "initials": "T", "orcid": "0000-0003-2082-5117", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb39d4a6cc8f439581040333ce92d6bb.json"}}, {"family": "Li", "given": "Henan", "initials": "H"}, {"family": "MacLachlan", "given": "Mac", "initials": "M"}, {"family": "Narayan", "given": "Jayanthi", "initials": "J", "orcid": "0000-0001-5125-0227", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58b00b867ac3442d8d9d316d9d2dc036.json"}}, {"family": "Nearchou", "given": "Finiki", "initials": "F", "orcid": "0000-0002-2018-9096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db4b9458035a4304a7e588be8533b39c.json"}}, {"family": "Nolan", "given": "Adam", "initials": "A"}, {"family": "O'Donovan", "given": "Mary-Ann", "initials": "MA", "orcid": "0000-0002-3378-5305", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af60d1c4e1464ffaa3c0499892d9fd0e.json"}}, {"family": "Santos", "given": "Flavia H", "initials": "FH", "orcid": "0000-0003-2592-9038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7e5d5f9645d48fabc19480b9af1d79e.json"}}, {"family": "\u0160i\u0161ka", "given": "Jan", "initials": "J", "orcid": "0000-0003-2379-2285", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5471f9d32d384e13a0fcc75e62df4766.json"}}, {"family": "Stainton", "given": "Tim", "initials": "T", "orcid": "0000-0002-5146-2497", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d297befd524e494f8f100394ab2cd84a.json"}}, {"family": "Tideman", "given": "Magnus", "initials": "M", "orcid": "0000-0002-7519-6488", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96ec2f02bc4b40ddadf2969252205539.json"}}, {"family": "Tossebro", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2022-04-04", "journal": {"title": "HRB Open Res", "issn": "2515-4826", "volume": "5", "pages": "27", "issn-l": null}, "abstract": "Background: A growing body of evidence attests to the disproportionate impact of COVID-19 on persons with intellectual and developmental disabilities (IDD) during the pandemic. This study asked caregivers about their perceptions of how COVID-19 impacted them and the people they support. Method: An online survey was conducted in 12 countries during August-September 2020 and sought information on demographics, support practices, information and training, experiences of COVID-19, social distancing, and wellbeing, as measured by the DASS12. This study reports on 3,754 family members, direct support professionals, and managers who participated in the survey. Results: Caregivers observed increases in depression/anxiety, stereotyped behaviours, aggression towards others and weight gain in the person(s) they supported. They also reported difficulties supporting the person(s) to access healthcare. Families reported reducing or ceasing employment and absorbed additional costs when supporting their family member. Direct support professionals experienced changes in staff shifts, staff absences, increased workload and hiring of casual staff. Caregivers' wellbeing revealed high levels of stress, depression, and less so anxiety. The strongest predictor of wellbeing among families was observation of changes in mood in the person(s) they supported, while for direct support professionals, the strongest predictors of wellbeing were reorganisation of staff shifts and increases in new direct support staff. Discussion: Findings support the contention of this population experiencing a disproportionate burden during the COVID-19 pandemic, reflecting historical inequities in access to healthcare and other human rights violations which are now protected under the United Nations Convention on the Rights of Persons with Disabilities.", "doi": "10.12688/hrbopenres.13497.1", "pmid": "35615436", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9111363"}], "notes": [], "created": "2022-06-21T17:49:34.094Z", "modified": "2022-06-21T17:49:34.715Z"}, {"entity": "publication", "iuid": "bbccc3d17c0f49868fc33a111d36c981", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bbccc3d17c0f49868fc33a111d36c981.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bbccc3d17c0f49868fc33a111d36c981"}}, "title": "Correlates of protection, viral load trajectories and symptoms in BA.1, BA.1.1 and BA.2 breakthrough infections in triple vaccinated healthcare workers", "authors": [{"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Greilert Norin", "given": "Nina", "initials": "N"}, {"family": "Bladh", "given": "Oscar", "initials": "O"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Ng", "given": "Henry", "initials": "H"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "Smed S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-4172-975X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc8af93ec4fa47959515a7b39b10a795.json"}}], "type": "posted-content", "published": "2022-04-03", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.04.02.22273333", "pmid": null, "labels": {"Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2022-10-13T15:17:24.431Z", "modified": "2023-06-19T14:27:45.410Z"}, {"entity": "publication", "iuid": "52c856fe22854e7c81a7c9caff161ffa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/52c856fe22854e7c81a7c9caff161ffa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/52c856fe22854e7c81a7c9caff161ffa"}}, "title": "Angiotensin-converting enzyme 2 and Transmembrane protease serine 2 in female and male patients with end-stage kidney disease.", "authors": [{"family": "Arefin", "given": "Samsul", "initials": "S", "orcid": "0000-0002-8050-9100", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0be84768aaf64d4484f0ba0ea99861d3.json"}}, {"family": "Hernandez", "given": "Leah", "initials": "L"}, {"family": "Ward", "given": "Liam J", "initials": "LJ"}, {"family": "Schwarz", "given": "Angelina", "initials": "A"}, {"family": "Barany", "given": "Peter", "initials": "P"}, {"family": "Stenvinkel", "given": "Peter", "initials": "P"}, {"family": "Kublickiene", "given": "Karolina", "initials": "K"}, {"family": "GOING-FWD Collaborators", "given": "", "initials": ""}], "type": "journal article", "published": "2022-04-02", "journal": {"title": "Eur J Clin Invest", "issn": "1365-2362", "pages": "e13786", "issn-l": null}, "abstract": "Individuals with chronic kidney disease are affected by acute respiratory syndrome coronavirus 2 (SARS-CoV-2) due to multiple comorbidities and altered immune system. The first step of the infection process is the binding of SARS-CoV-2 with angiotensin-converting enzyme 2 (ACE2) receptor, followed by its priming by transmembrane protease serine 2 (TMPRSS2). We hypothesized that circulating soluble ACE2 levels, as well as the expressions of ACE2 and TMPRSS2 in the microvasculature, are increased in patients with end-stage kidney disease (ESKD).\n\nA total of 210 participants were enrolled, representing 80 ESKD patients and 73 non-CKD controls for soluble ACE2, and 31 ESKD and 26 non-CKD controls for vasculature and fat tissue bioassays. We have assessed ACE2 expression in blood using ELISA and in tissue using immunofluorescence.\n\nSoluble ACE2 levels were higher in ESKD patients compared to controls however, there is no sex difference observed. In ESKD and controls, soluble ACE2 positively correlated with IL-6 and hsCRP respectively. Similarly, ACE2 tissue expression in the vasculature was higher in ESKD patients, moreover, this higher ACE2 expression was observed only in male ESKD patients. In addition, TMPRSS2 expression was observed in vessels from males and females but showed no sex difference. The expression of ACE2 receptor was higher in ESKD patients on ACE-inhibitor/angiotensin blocker treatment.\n\nESKD is associated with increased ACE2 levels in the circulation and pronounced in male vasculature, however further studies are warranted to assess possible sex differences on specific treatment regime(s) for different comorbidities present in ESKD.", "doi": "10.1111/eci.13786", "pmid": "35366343", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-04-04T06:22:59.917Z", "modified": "2022-04-04T06:23:32.705Z"}, {"entity": "publication", "iuid": "ce32d7ce04f74c4e8ee3ca08a4e892e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ce32d7ce04f74c4e8ee3ca08a4e892e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ce32d7ce04f74c4e8ee3ca08a4e892e7"}}, "title": "ABO and RhD blood group are not associated with mortality and morbidity in critically ill patients; a multicentre observational study of 29 512 patients.", "authors": [{"family": "Kander", "given": "Thomas", "initials": "T"}, {"family": "Bjurstr\u00f6m", "given": "Martin F", "initials": "MF"}, {"family": "Frigyesi", "given": "Attila", "initials": "A"}, {"family": "J\u00f6ud", "given": "Magnus", "initials": "M"}, {"family": "Nilsson", "given": "Caroline U", "initials": "CU"}], "type": "journal article", "published": "2022-04-02", "journal": {"title": "BMC Anesthesiol", "issn": "1471-2253", "volume": "22", "issue": "1", "pages": "91", "issn-l": null}, "abstract": "The ABO and RhD blood group represent antigens on the surface of erythrocytes. The ABO blood group antigens are also present on multiple other cells. Interestingly, previous studies have demonstrated associations between the blood group and many types of disease. The present study aimed to identifying associations between the ABO blood group, the RhD blood group, and morbidity and mortality in a mixed cohort and in six pre-defined subgroups of critically ill patients.\n\nAdult patients admitted to any of the five intensive care units (ICUs) in the Scania Region, Sweden, between February 2007 and April 2021 were eligible for inclusion. The outcomes were mortality analysed at 28- and 90-days as well as at the end of observation and morbidity measured using days alive and free of (DAF) invasive ventilation (DAF ventilation) and DAF circulatory support, including vasopressors or inotropes (DAF circulation), maximum Sequential Organ Failure Assessment score (SOFAmax) the first 28 days after admission and length of stay. All outcomes were analysed in separate multivariable regression models adjusted for age and sex. In addition, in a sensitivity analysis, five subgroups of patients with the main diagnoses sepsis, septic shock, acute respiratory distress syndrome, cardiac arrest and trauma were analysed using the same separate multivariable regression models.\n\nIn total, 29,512 unique patients were included in the analyses. There were no significant differences for any of the outcomes between non-O blood groups and blood group O, or between RhD blood groups. In the sensitivity analysis of subgroups, there were no differences in mortality between non-O blood groups and blood group O or between the RhD blood groups. AB was the most common blood group in the COVID-19 cohort.\n\nThe ABO and RhD blood group do not influence mortality or morbidity in a general critically ill patient population.", "doi": "10.1186/s12871-022-01626-4", "pmid": "35366803", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12871-022-01626-4"}], "notes": [], "created": "2022-04-04T06:22:38.196Z", "modified": "2022-04-04T06:22:38.231Z"}, {"entity": "publication", "iuid": "dbd6140519994f4bad11d82be6f43d99", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dbd6140519994f4bad11d82be6f43d99.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dbd6140519994f4bad11d82be6f43d99"}}, "title": "VCA in the Era of the COVID-19 Pandemic.", "authors": [{"family": "Petruzzo", "given": "Palmina", "initials": "P"}, {"family": "Kanitakis", "given": "Jean", "initials": "J"}, {"family": "Sardu", "given": "Claudia", "initials": "C"}, {"family": "Bassiri Gharb", "given": "Bahar", "initials": "B"}, {"family": "Morelon", "given": "Emmanuel", "initials": "E"}, {"family": "Amer", "given": "Hatem", "initials": "H"}, {"family": "Barret", "given": "Juan", "initials": "J"}, {"family": "Burt", "given": "James", "initials": "J"}, {"family": "Brandacher", "given": "Gerald", "initials": "G"}, {"family": "Gomez", "given": "Tomas", "initials": "T"}, {"family": "Kay", "given": "Simon", "initials": "S"}, {"family": "Kaminska", "given": "Dorotha", "initials": "D"}, {"family": "Kaufman", "given": "Christina L", "initials": "CL"}, {"family": "Kumar", "given": "Dinesh S", "initials": "DS"}, {"family": "Iglesias", "given": "Martin", "initials": "M"}, {"family": "Iyer", "given": "Subramania", "initials": "S"}, {"family": "Landin", "given": "Luis", "initials": "L"}, {"family": "Lanzetta", "given": "Marco", "initials": "M"}, {"family": "Lassus", "given": "Patrick", "initials": "P"}, {"family": "Levin", "given": "Scott", "initials": "S"}, {"family": "Papay", "given": "Francis", "initials": "F"}, {"family": "Pomahac", "given": "Bohdan", "initials": "B"}, {"family": "Sassu", "given": "Paolo", "initials": "P"}, {"family": "Satbhai", "given": "Nilesh G", "initials": "NG"}, {"family": "Talbot", "given": "Simon", "initials": "S"}, {"family": "VCA-COVID Survey Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-04-01", "journal": {"title": "Transplantation", "issn": "1534-6080", "volume": "106", "issue": "4", "pages": "690-692", "issn-l": null}, "abstract": null, "doi": "10.1097/TP.0000000000004041", "pmid": "35333847", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "00007890-202204000-00005"}, {"db": "pmc", "key": "PMC8942593"}], "notes": [], "created": "2022-04-04T06:56:37.125Z", "modified": "2022-04-04T06:56:50.268Z"}, {"entity": "publication", "iuid": "96e41f1753ce4163b558b31d1be31822", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/96e41f1753ce4163b558b31d1be31822.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/96e41f1753ce4163b558b31d1be31822"}}, "title": "Public risk perception and behaviours towards COVID-19 during the first and second waves in Nigeria: a secondary data analysis.", "authors": [{"family": "Ochu", "given": "Chinwe Lucia", "initials": "CL", "orcid": "0000-0002-0630-7332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f390fa99a654ff899f5e9df6fbaf88e.json"}}, {"family": "Onoja", "given": "Michael", "initials": "M"}, {"family": "Olatunji", "given": "David", "initials": "D"}, {"family": "Okusanya", "given": "Babasola O", "initials": "BO"}, {"family": "Usuwa", "given": "Ifeoma Sophia", "initials": "IS", "orcid": "0000-0002-9584-784X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/faff911036d446d2aa187ecb925dbce7.json"}}, {"family": "Akeju", "given": "David O", "initials": "DO"}, {"family": "Disu", "given": "Yahya", "initials": "Y"}, {"family": "Adejo", "given": "Samuel Ojima", "initials": "SO"}, {"family": "Eziechina", "given": "Sunday", "initials": "S"}, {"family": "Nwiyi", "given": "Gloria", "initials": "G"}, {"family": "Okediran", "given": "James Olatunde", "initials": "JO"}, {"family": "Elimian", "given": "Kelly Osezele", "initials": "KO", "orcid": "0000-0003-2729-1613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/695dddf720414c3585d35b30184f0178.json"}}, {"family": "Akande", "given": "Oluwatosin Wuraola", "initials": "OW"}, {"family": "Dunkwu", "given": "Lauryn", "initials": "L"}, {"family": "Fagbemi", "given": "Babafunke", "initials": "B"}, {"family": "Aisiri", "given": "Adolor", "initials": "A"}, {"family": "Agogo", "given": "Emmanuel A", "initials": "EA"}, {"family": "Ebenso", "given": "Bassey", "initials": "B", "orcid": "0000-0003-4147-0968", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40b960008ed04f54adb2d62d088232ee.json"}}, {"family": "Oke", "given": "David Adewale", "initials": "DA"}, {"family": "Igumbor", "given": "Ehimario", "initials": "E"}, {"family": "Ihekweazu", "given": "Chikwe", "initials": "C"}], "type": "journal article", "published": "2022-04-01", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "4", "pages": "e058747", "issn-l": "2044-6055"}, "abstract": "To describe changes in public risk perception and risky behaviours during the first wave (W1) and second wave (W2) of COVID-19 in Nigeria, associated factors and observed trend of the outbreak.\n\nA secondary data analysis of cross-sectional telephone-based surveys conducted during the W1 and W2 of COVID-19 in Nigeria.\n\nNigeria.\n\nData from participants randomly selected from all states in Nigeria.\n\nRisk perception for COVID-19 infection categorised as risk perceived and risk not perceived.\n\nCompliance to public health and social measures (PHSMs) categorised as compliant; non-compliant and indifferent.\n\nComparison of frequencies during both waves using \u03c72 statistic to test for associations. Univariate and multivariate logistic regression analyses helped estimate the unadjusted and adjusted odds of risk perception of oneself contracting COVID-19. Level of statistical significance was set at p<0.05.\n\nTriangulated datasets had a total of 6401 respondents, majority (49.5%) aged 25-35 years. Overall, 55.4% and 56.1% perceived themselves to be at risk of COVID-19 infection during the W1 and W2, respectively. A higher proportion of males than females perceived themselves to be at risk during the W1 (60.3% vs 50.3%, p<0.001) and the W2 (58.3% vs 52.6%, p<0.05). Residing in the south-west was associated with not perceiving oneself at risk of COVID-19 infection (W1-AOdds Ratio (AOR) 0.28; 95% CI 0.20 to 0.40; W2-AOR 0.71; 95% CI 0.52 to 0.97). There was significant increase in non-compliance to PHSMs in the W2 compared with W1. Non-compliance rate was higher among individuals who perceived themselves not to be at risk of getting infected (p<0.001).\n\nRisk communication and community engagement geared towards increasing risk perception of COVID-19 should be implemented, particularly among the identified population groups. This could increase adherence to PHSMs and potentially reduce the burden of COVID-19 in Nigeria.", "doi": "10.1136/bmjopen-2021-058747", "pmid": "35365542", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-058747"}], "notes": [], "created": "2022-04-04T06:23:51.989Z", "modified": "2022-04-04T06:24:14.801Z"}, {"entity": "publication", "iuid": "c14bd0e3ce4b4000bd392cb482fb2de7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c14bd0e3ce4b4000bd392cb482fb2de7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c14bd0e3ce4b4000bd392cb482fb2de7"}}, "title": "Factors associated with physical activity reduction in Swedish older adults during the first COVID-19 outbreak: a longitudinal population-based study.", "authors": [{"family": "Sj\u00f6berg", "given": "Linnea", "initials": "L", "orcid": "0000-0002-1621-1174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20688dd7e9de43798d5261b9f1e227cf.json"}}, {"family": "Triolo", "given": "Federico", "initials": "F"}, {"family": "Saadeh", "given": "Marguerita", "initials": "M"}, {"family": "Dekhtyar", "given": "Serhiy", "initials": "S"}, {"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A"}, {"family": "Welmer", "given": "Anna-Karin", "initials": "AK"}], "type": "journal article", "published": "2022-04-01", "journal": {"title": "Eur Rev Aging Phys Act", "issn": "1813-7253", "volume": "19", "issue": "1", "pages": "9", "issn-l": null}, "abstract": "Physical activity (PA) decreased during the COVID-19 pandemic, especially among older adults, potentially leading to adverse consequences for their health. However, factors associated with reductions of PA during the pandemic have not been examined in a population-based sample of older adults. Thus, the aim of this study was to explore the association of pre-pandemic physical, mental, social and lifestyle factors with reductions in PA in older adults during the first wave of COVID-19, and whether the associations differed by age and sex.\n\nA population-based sample of 624 participants aged 65-99 years were identified from the Swedish National study on Aging and Care in Kungsholmen (SNAC-K) COVID19 Study. Information on pre-pandemic factors was collected through clinical examinations, interviews, and self-administered questionnaires in 2016-2019. Changes in light and intense PA during the first wave of the pandemic (May-September 2020) were self-reported. Data were analyzed using multiple logistic regression models, stratified by age (<70 vs. >80 years) and sex.\n\nThere was an association between pre-pandemic levels of higher depressive symptom burden (Odds Ratio (OR): 2.6, 95% Confidence Interval (CI): 1.1-6.4, <70 years), and impaired balance (OR: 1.7, 95% CI: 1.0-2.8, >80 years old) with reductions in light-intensity PA. Furthermore, the presence of musculoskeletal disease (OR: 1.8, 95% CI: 1.1-2.9, <70 years; OR: 2.3, 95% CI: 1.2-4.4, men), moderate/high levels of neuroticism (OR: 1.6, 95% CI: 1.0-2.6, <70 years; OR: 2.2, 95% CI: 1.3-3.5, women), and poor levels of social support (OR: 2.2, 95% CI: 1.2-4.3, >80 years) were related to reductions in higher-intensity PA. Those who were current smokers (OR: 0.3, 95% CI: 0.1-0.8, <70 years; OR: 0.2, 95% CI: 0.06-0.7, women), or had impaired balance (OR: 0.4, 95% CI: 0.2-0.8, >80 years) were less likely to reduce their levels of higher-intensity PA.\n\nFor future pandemics or waves of COVID-19, development of strategies is warranted for older individuals with psychiatric- or physical illness/dysfunction, as well as those with poor social support to counteract reductions in physical activities.", "doi": "10.1186/s11556-022-00287-z", "pmid": "35365065", "labels": {"Type: Journal article": null, "Topics: Register-based research": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s11556-022-00287-z"}], "notes": [], "created": "2022-04-04T06:24:35.714Z", "modified": "2022-04-04T06:24:35.794Z"}, {"entity": "publication", "iuid": "e145bce692554da09fd3e92b3da5536e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e145bce692554da09fd3e92b3da5536e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e145bce692554da09fd3e92b3da5536e"}}, "title": "Facilitators and barriers for effective staff work in Swedish National governmental crisis response to the COVID-19 pandemic.", "authors": [{"family": "Westman", "given": "Anja", "initials": "A", "orcid": "0000-0002-2794-5026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8650cc30d2a14d79aa16b2e4a3024fe2.json"}}, {"family": "Hugelius", "given": "Karin", "initials": "K", "orcid": "0000-0003-0534-4593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f7d4e9ff0f645598a2473e42806066a.json"}}, {"family": "Weinstein", "given": "Eric", "initials": "E", "orcid": "0000-0002-1147-5656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e061be2d669425e9d462d75d69832ad.json"}}, {"family": "Kurland", "given": "Lisa", "initials": "L"}], "type": "journal article", "published": "2022-04-01", "journal": {"title": "Disaster Med Public Health Prep", "issn": "1938-744X", "pages": "1-16", "issn-l": "1935-7893"}, "abstract": "The COVID-19 crisis response in Sweden was managed foremost by a collaboration of several national agencies. Normally their strategical and operational collaboration is limited, but the pandemic required new and unfamiliar collaborations.\n\nThis study aimed to clarify the facilitators and barriers of perceived effective staff work within and between four national agencies.\n\nA qualitative study of 10 participants with leading roles within the four national agencies' crisis organization, recruited via snowball sampling. The interviews were conducted between August - November 2020 and analyzed using content analysis.\n\nFour categories emerged from the analysis: individual characteristics; intra-agency organization; interorganizational collaboration and governmental directives. Subcategories crystalized from the data were analyzed and divided into factors facilitating or to function as barriers for effective staff work.\n\nIndividual factors such as attitude and approach were important for perceived effective staff work as well as clear mandates and structure of the organization. Barriers for perceived effective staff work includes lack of network, the complexity of the mission and organizational structures as well as lack of preparations and unclear mandates. Although flexibility and adaptability are necessary, they cannot always be planned, but be incorporated indirectly by selecting suitable individuals and optimizing organizational planning.", "doi": "10.1017/dmp.2022.91", "pmid": "35362402", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S193578932200091X"}], "notes": [], "created": "2022-04-04T06:32:24.772Z", "modified": "2022-04-04T06:32:24.868Z"}, {"entity": "publication", "iuid": "9cda8b3c808c40ca99fdaa75eafc009e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9cda8b3c808c40ca99fdaa75eafc009e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9cda8b3c808c40ca99fdaa75eafc009e"}}, "title": "Colon cancer treatment in Sweden during the COVID-19 pandemic: a nationwide register-based study.", "authors": [{"family": "Ekl\u00f6v", "given": "Karolina", "initials": "K", "orcid": "0000-0001-5059-5856", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49b27fb96266496d8561f6c0869da3f6.json"}}, {"family": "Nygren", "given": "Jonas", "initials": "J"}, {"family": "Bringman", "given": "Sven", "initials": "S"}, {"family": "L\u00f6fgren", "given": "Jenny", "initials": "J"}, {"family": "Sj\u00f6vall", "given": "Annika", "initials": "A"}, {"family": "Nordenvall", "given": "Caroline", "initials": "C"}, {"family": "Everhov", "given": "\u00c5sa H", "initials": "\u00c5H"}], "type": "journal article", "published": "2022-04-01", "journal": {"title": "Colorectal Dis", "issn": "1463-1318", "issn-l": null}, "abstract": "The COVID-19 pandemic has reduced the capacity to diagnose and treat cancer worldwide due to the prioritization of COVID-19 treatment.\n\nTo investigate treatment and outcomes of colon cancer in Sweden before and during the COVID-19 pandemic.\n\nIn an observational study, using the Swedish Colorectal Cancer Registry, we included (i) all Swedish patients diagnosed with colon cancer, and (ii) all patients undergoing surgery for colon cancer, in 2016-2020. Incidence of colon cancer, treatments and outcomes in 2020 were compared with 2019.\n\nThe number of colon cancer cases in Sweden in April-May 2020 was 27% lower than the previous year, whereas no difference was observed on an annual level (4589 vs 4763 patients (-4%)). Among patients with colon cancer undergoing surgery in 2020, the proportion resections was 93% vs 94% in 2019, with no increase in acute resections. Time from diagnosis to elective surgery decreased (29 days vs 33 days in 2020 vs 2019). In 2020, more patients underwent a 2-stage procedure with a diverting stoma as first surgery (6.1%) vs (4.4%) in 2019 (p=0.0020) and more patients were treated with preoperative chemotherapy (5.1%) vs (3,5%) 2019 (p= 0.0016). The proportion of patients that underwent laparoscopic surgery increased from 54% to 58% (p=0.0017) There were no differences in length of stay, surgical complications, reoperation, ICU-stay or 30-day mortality between the years.\n\nBased on nationwide annual data, we did not observe adverse effects of the COVID-19 pandemic on colon cancer treatment and short time outcomes in Sweden.", "doi": "10.1111/codi.16129", "pmid": "35362199", "labels": {"Category: Health": null, "Type: Journal article": null, "Topics: Register-based research": null}, "xrefs": [], "notes": [], "created": "2022-04-04T06:32:46.143Z", "modified": "2022-04-04T06:32:46.195Z"}, {"entity": "publication", "iuid": "5fec314aa8ce47189a0984489f9241b5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5fec314aa8ce47189a0984489f9241b5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5fec314aa8ce47189a0984489f9241b5"}}, "title": "The social patterning of Covid-19 vaccine uptake in older adults: A register-based cross-sectional study in Sweden.", "authors": [{"family": "Spetz", "given": "Malin", "initials": "M"}, {"family": "Lundberg", "given": "Lisa", "initials": "L"}, {"family": "Nwaru", "given": "Chioma", "initials": "C"}, {"family": "Li", "given": "Huiqi", "initials": "H"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Hammar", "given": "Niklas", "initials": "N"}, {"family": "Rosvall", "given": "Maria", "initials": "M"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "15", "pages": "100331", "issn-l": null}, "abstract": "A broad vaccination coverage is crucial for preventing the spread of Covid-19 and reduce serious illness or death. The aim of this study was to examine social inequalities in Covid-19 vaccination uptake as of 17th May 2021 among Swedish adults aged \u2265 60 years.\n\nThe study population comprised a general population cohort aged 60 years or older (n = 350,805), representative of the Swedish population. Data were collected through the nationwide linked multi-register observational study SCIFI-PEARL, and associations between sociodemographic determinants and Covid-19 vaccination uptake were analysed using logistic regression. Intersectional analyses of sociodemographic heterogeneity were performed by taking several overlapping social dimensions into account. Data availability extended to 17 May 2021.\n\nThe overall vaccination coverage was 87\u00b72% by 17th May 2021. Younger age, male sex, lower income, living alone, and being born outside Sweden, were all associated with a lower uptake of vaccination. The lowest Covid-19 vaccination uptake was seen in individuals born in low-or middle-income countries, of which only 60% had received vaccination, with an odds ratio (OR) of not being vaccinated of 6\u00b705 (95% CI: 5\u00b785-6\u00b726) compared to individuals born in Sweden. These associations persisted after adjustments for possible confounding factors. The intersectional analyses showed even larger variations in vaccination in cross-classified sociodemographic subgroups (ranging from 44% to 97%) with marked differences in uptake of vaccination within sociodemographic groups.\n\nThe uptake of Covid-19 vaccine during the spring of 2021 in Sweden varied substantially both between and within sociodemographic groups. The use of an intersectional approach, taking several overlapping social dimensions into account at the same time rather than only using one-dimensional measures, contributes to a better understanding of the complexity in the uptake of vaccination.\n\nSciLifeLab / Knut & Alice Wallenberg Foundation, Swedish Research Council, Swedish government ALF-agreement, FORMAS.", "doi": "10.1016/j.lanepe.2022.100331", "pmid": "35252941", "labels": {"Research Area: Vaccine": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Health": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC8881226"}, {"db": "pii", "key": "S2666-7762(22)00024-2"}], "notes": [], "created": "2022-11-29T14:27:55.286Z", "modified": "2022-11-29T14:27:55.300Z"}, {"entity": "publication", "iuid": "ed71d308d25d45d4a52a25812056550f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed71d308d25d45d4a52a25812056550f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed71d308d25d45d4a52a25812056550f"}}, "title": "The effect of the COVID-19 pandemic on severe asthma care in Europe: will care change for good?", "authors": [{"family": "Eger", "given": "Katrien", "initials": "K", "orcid": "0000-0002-9628-2174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ec87651e0164ace9872a7186867fa83.json"}}, {"family": "Paroczai", "given": "Dora", "initials": "D"}, {"family": "Bacon", "given": "Alison", "initials": "A", "orcid": "0000-0003-4279-3814", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b6040010eb24885832dc5ed684e7cfc.json"}}, {"family": "Schleich", "given": "Florence", "initials": "F"}, {"family": "Sergejeva", "given": "Svetlana", "initials": "S"}, {"family": "Bourdin", "given": "Arnaud", "initials": "A", "orcid": "0000-0002-4645-5209", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f88bf68759c246f3a1a7df2749bf606c.json"}}, {"family": "Vachier", "given": "Isabelle", "initials": "I"}, {"family": "Zervas", "given": "Eleftherios", "initials": "E", "orcid": "0000-0001-7436-4550", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0d338ea2b724ccab920b95ae3c42ffe.json"}}, {"family": "Katsoulis", "given": "Konstantinos", "initials": "K"}, {"family": "Papapetrou", "given": "Dimosthenis", "initials": "D"}, {"family": "Kostikas", "given": "Konstantinos", "initials": "K", "orcid": "0000-0003-0774-3942", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3eaa831d14b14f5e9188d8f05ede185f.json"}}, {"family": "Csoma", "given": "Zsuzsanna", "initials": "Z"}, {"family": "Heffler", "given": "Enrico", "initials": "E"}, {"family": "Canonica", "given": "Giorgio Walter", "initials": "GW", "orcid": "0000-0001-8467-2557", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ccaf06bd57b438fabe0a7c904259881.json"}}, {"family": "Grisle", "given": "Ineta", "initials": "I"}, {"family": "Bieksiene", "given": "Kristina", "initials": "K"}, {"family": "Palacionyte", "given": "Jolita", "initials": "J"}, {"family": "Ten Brinke", "given": "Anneke", "initials": "A"}, {"family": "Hashimoto", "given": "Simone", "initials": "S", "orcid": "0000-0001-8995-3817", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5d3f0acc6674d52bd765e2c0e58f4e1.json"}}, {"family": "Smeenk", "given": "Frank W J M", "initials": "FWJM"}, {"family": "Braunstahl", "given": "Gert-Jan", "initials": "GJ", "orcid": "0000-0001-7671-3742", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/129b78ac29b44216a8f4267281441349.json"}}, {"family": "van der Sar", "given": "Simone", "initials": "S"}, {"family": "Mih\u0103l\u0163an", "given": "Florin", "initials": "F"}, {"family": "Nenasheva", "given": "Natalia", "initials": "N"}, {"family": "Peredelskaya", "given": "Marina", "initials": "M"}, {"family": "Zvezdin", "given": "Biljana", "initials": "B"}, {"family": "\u010cekerevac", "given": "Ivan", "initials": "I"}, {"family": "Hromi\u0161", "given": "Sanja", "initials": "S"}, {"family": "\u0106upurdija", "given": "Vojislav", "initials": "V"}, {"family": "Lazic", "given": "Zorica", "initials": "Z"}, {"family": "Milenkovic", "given": "Branislava", "initials": "B"}, {"family": "Dimic-Janjic", "given": "Sanja", "initials": "S"}, {"family": "Yasinska", "given": "Valentyna", "initials": "V"}, {"family": "Dahl\u00e9n", "given": "Barbro", "initials": "B"}, {"family": "Bossios", "given": "Apostolos", "initials": "A", "orcid": "0000-0002-0494-2690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/494bc3af38b0417186d9444f1ee3fa97.json"}}, {"family": "Lazarinis", "given": "Nikolaos", "initials": "N"}, {"family": "Aronsson", "given": "David", "initials": "D"}, {"family": "Egesten", "given": "Arne", "initials": "A"}, {"family": "Munir", "given": "Abul Kashem Mohammad", "initials": "AKM"}, {"family": "Ahlbeck", "given": "Lars", "initials": "L"}, {"family": "Janson", "given": "Christer", "initials": "C", "orcid": "0000-0001-5093-6980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba296cda8ef74430ad5457e71b7dae94.json"}}, {"family": "\u0160krgat", "given": "Sabina", "initials": "S"}, {"family": "Edelbaher", "given": "Natalija", "initials": "N"}, {"family": "Leuppi", "given": "Joerg", "initials": "J"}, {"family": "Jaun", "given": "Fabienne", "initials": "F"}, {"family": "R\u00fcdiger", "given": "Jochen", "initials": "J"}, {"family": "Pavlov", "given": "Nikolay", "initials": "N"}, {"family": "Gianella", "given": "Pietro", "initials": "P"}, {"family": "Fischer", "given": "Reta", "initials": "R"}, {"family": "Charbonnier", "given": "Florian", "initials": "F"}, {"family": "Chaudhuri", "given": "Rekha", "initials": "R"}, {"family": "Smith", "given": "Steven James", "initials": "SJ"}, {"family": "Doe", "given": "Simon", "initials": "S"}, {"family": "Fawdon", "given": "Michelle", "initials": "M"}, {"family": "Masoli", "given": "Matthew", "initials": "M", "orcid": "0000-0003-0909-0148", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83de342198de485ea699edc035980c3c.json"}}, {"family": "Heaney", "given": "Liam", "initials": "L"}, {"family": "Haitchi", "given": "Hans Michael", "initials": "HM", "orcid": "0000-0001-8603-302X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6de760fa29414bf399a0a03e50ddc057.json"}}, {"family": "Kurukulaaratchy", "given": "Ramesh", "initials": "R"}, {"family": "Fulton", "given": "Olivia", "initials": "O", "orcid": "0000-0001-7358-0219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/707e706c3f8149e4aa9a8009017d0028.json"}}, {"family": "Frankem\u00f6lle", "given": "Betty", "initials": "B"}, {"family": "Gibson", "given": "Toni", "initials": "T", "orcid": "0000-0001-8684-8624", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e804ad5e718648acaddacf249d414ae2.json"}}, {"family": "Needham", "given": "Karen", "initials": "K"}, {"family": "Howarth", "given": "Peter", "initials": "P", "orcid": "0000-0003-0619-7927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ac4536cccd642efa26db94364dceac2.json"}}, {"family": "Djukanovic", "given": "Ratko", "initials": "R"}, {"family": "Bel", "given": "Elisabeth", "initials": "E"}, {"family": "Hyland", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "ERJ Open Res", "issn": "2312-0541", "volume": "8", "issue": "2", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has put pressure on healthcare services, forcing the reorganisation of traditional care pathways. We investigated how physicians taking care of severe asthma patients in Europe reorganised care, and how these changes affected patient satisfaction, asthma control and future care.\n\nIn this European-wide cross-sectional study, patient surveys were sent to patients with a physician-diagnosis of severe asthma, and physician surveys to severe asthma specialists between November 2020 and May 2021.\n\n1101 patients and 268 physicians from 16 European countries contributed to the study. Common physician-reported changes in severe asthma care included use of video/phone consultations (46%), reduced availability of physicians (43%) and change to home-administered biologics (38%). Change to phone/video consultations was reported in 45% of patients, of whom 79% were satisfied or very satisfied with this change. Of 709 patients on biologics, 24% experienced changes in biologic care, of whom 92% were changed to home-administered biologics and of these 62% were satisfied or very satisfied with this change. Only 2% reported worsening asthma symptoms associated with changes in biologic care. Many physicians expect continued implementation of video/phone consultations (41%) and home administration of biologics (52%).\n\nChange to video/phone consultations and home administration of biologics was common in severe asthma care during the COVID-19 pandemic and was associated with high satisfaction levels in most but not all cases. Many physicians expect these changes to continue in future severe asthma care, though satisfaction levels may change after the pandemic.", "doi": "10.1183/23120541.00065-2022", "pmid": "35582679", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00065-2022"}, {"db": "pmc", "key": "PMC8994963"}], "notes": [], "created": "2022-06-21T18:03:14.205Z", "modified": "2022-06-21T18:03:33.900Z"}, {"entity": "publication", "iuid": "b9884b197f3146b0aabf7d635fbd8ab2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9884b197f3146b0aabf7d635fbd8ab2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9884b197f3146b0aabf7d635fbd8ab2"}}, "title": "Short-term rental market crisis management during the COVID-19 pandemic: Stakeholders' perspectives.", "authors": [{"family": "Miguel", "given": "Cristina", "initials": "C"}, {"family": "Pechurina", "given": "Anna", "initials": "A"}, {"family": "Kirkulak-Uludag", "given": "Berna", "initials": "B"}, {"family": "Drotarova", "given": "Maria Hadjielia", "initials": "MH"}, {"family": "Duman\u010di\u0107", "given": "Kosjenka", "initials": "K"}, {"family": "Braje", "given": "Ivana Na\u010dinovi\u0107", "initials": "IN"}, {"family": "Giglio", "given": "Carlo", "initials": "C"}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Int J Hosp Manag", "issn": "0278-4319", "issn-l": null, "volume": "102", "issue": null, "pages": "103147"}, "abstract": "Contingency plans and crisis management strategies have been implemented by the short-term rental industry to deal with the COVID-19 pandemic. This paper examines the strategies adopted by three key groups of stakeholders: short-term rental platforms (e.g. Airbnb, Booking.com), service providers (represented by property management companies and short-term rental associations) and policymakers/tourism experts. The professional service providers, in particular, constitute a significant share of the short-term rental industry, but have not received much scholarly attention. In this respect, our study fills this gap by bringing attention to unexplored segments of the short-term rental industry. By examining and comparing the responses from these key groups, the paper contributes to the ongoing research about the workings of the short-term rental industry and its responses to the COVID-19 crisis.", "doi": "10.1016/j.ijhm.2022.103147", "pmid": "35035022", "labels": {"Topics: Register-based research": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0278-4319(22)00009-3"}, {"db": "pmc", "key": "PMC8752289"}], "notes": [], "created": "2022-01-27T07:40:12.388Z", "modified": "2022-11-22T05:38:29.271Z"}, {"entity": "publication", "iuid": "98335ad0296a4ef6a2c0ac2bebc0ae7b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/98335ad0296a4ef6a2c0ac2bebc0ae7b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/98335ad0296a4ef6a2c0ac2bebc0ae7b"}}, "title": "Prevention of Recurrent Childhood Caries with Probiotic Supplements: A Randomized Controlled Trial with a 12-Month Follow-Up.", "authors": [{"family": "Hassl\u00f6f", "given": "P", "initials": "P", "orcid": "0000-0002-7670-3103", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41a254437667432fb88ce0f53d350059.json"}}, {"family": "Granqvist", "given": "L", "initials": "L"}, {"family": "Stecks\u00e9n-Blicks", "given": "C", "initials": "C"}, {"family": "Twetman", "given": "S", "initials": "S"}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Probiotics Antimicrob Proteins", "issn": "1867-1314", "volume": "14", "issue": "2", "pages": "384-390", "issn-l": null}, "abstract": "The aim of this study was to evaluate the effect of drops containing probiotic bacteria on the recurrence of dental caries in preschool children. The study employed a randomized, placebo-controlled, double-blinded design with two parallel arms. 38 preschool children were enrolled after comprehensive restorative treatment under general anesthesia or conscious sedation (baseline), and they were followed up after 6 and 12 months. Parents of children in the test group were instructed to give 5 daily drops containing two strains of Limosilactobacillus reuteri (DSM 17938 and ATCC PTA 5289) at bedtime. The placebo drops were identically composed but lacked bacteria. The duration of the intervention was 12 months. The primary endpoint was recurrence of new caries lesions on subject level (yes/no), and secondary endpoints were presence of dental plaque and gingivitis. We found high rate of recurrent moderate and extensive lesions after 12 months (67%) but there were no significant differences between the groups. We observed no beneficial effects on dental plaque or gingival inflammation. The findings were however uncertain and inconclusive due to lack of power, a consequence of the COVID-19 pandemic. ClinTrials.gov Identifier: (NCT04929340), June 18, 2021; retrospectively registered.", "doi": "10.1007/s12602-022-09913-9", "pmid": "35083729", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s12602-022-09913-9"}, {"db": "pmc", "key": "PMC8791080"}, {"db": "ClinicalTrials.gov", "key": "NCT04929340"}], "notes": [], "created": "2022-01-31T11:47:22.815Z", "modified": "2022-06-21T18:22:19.051Z"}, {"entity": "publication", "iuid": "9c92fc99dc4e4140973b314269871fb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9c92fc99dc4e4140973b314269871fb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9c92fc99dc4e4140973b314269871fb1"}}, "title": "Preterm birth after the introduction of COVID-19 mitigation measures in Norway, Sweden, and Denmark: a registry-based difference-in-differences study.", "authors": [{"family": "Oakley", "given": "Laura L", "initials": "LL"}, {"family": "\u00d6rtqvist", "given": "Anne K", "initials": "AK"}, {"family": "Kinge", "given": "Jonas", "initials": "J"}, {"family": "Hansen", "given": "Anne Vinkel", "initials": "AV"}, {"family": "Petersen", "given": "Tanja Gram", "initials": "TG"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Telle", "given": "Kjetil E", "initials": "KE"}, {"family": "Magnus", "given": "Maria C", "initials": "MC"}, {"family": "Mortensen", "given": "Laust Hvas", "initials": "LH"}, {"family": "Nybo Andersen", "given": "Anne-Marie", "initials": "AM"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Am J Obstet Gynecol", "issn": "1097-6868", "volume": "226", "issue": "4", "pages": "550.e1-550.e22", "issn-l": null}, "abstract": "Although some studies have reported a decrease in preterm birth following the start of the COVID-19 pandemic, the findings are inconsistent.\n\nThis study aimed to compare the incidences of preterm birth before and after the introduction of COVID-19 mitigation measures in Scandinavian countries using robust population-based registry data.\n\nThis was a registry-based difference-in-differences study using births from January 2014 through December 2020 in Norway, Sweden, and Denmark. The changes in the preterm birth (<37 weeks) rates before and after the introduction of COVID-19 mitigation measures (set to March 12, 2020) were compared with the changes in preterm birth before and after March 12 from 2014 to 2019. The differences per 1000 births were calculated for 2-, 4-, 8-, 12-, and 16-week intervals before and after March 12. The secondary analyses included medically indicated preterm birth, spontaneous preterm birth, and very preterm (<32 weeks) birth.\n\nA total of 1,519,521 births were included in this study. During the study period, 5.6% of the births were preterm in Norway and Sweden, and 5.7% were preterm in Denmark. There was a seasonal variation in the incidence of preterm birth, with the highest incidence during winter. In all the 3 countries, there was a slight overall decline in preterm births from 2014 to 2020. There was no consistent evidence of a change in the preterm birth rates following the introduction of COVID-19 mitigation measures, with difference-in-differences estimates ranging from 3.7 per 1000 births (95% confidence interval, -3.8 to 11.1) for the first 2 weeks after March 12, 2020, to -1.8 per 1000 births (95% confidence interval, -4.6 to 1.1) in the 16 weeks after March 12, 2020. Similarly, there was no evidence of an impact on medically indicated preterm birth, spontaneous preterm birth, or very preterm birth.\n\nUsing high-quality national data on births in 3 Scandinavian countries, each of which implemented different approaches to address the pandemic, there was no evidence of a decline in preterm births following the introduction of COVID-19 mitigation measures.", "doi": "10.1016/j.ajog.2021.11.034", "pmid": "34774824", "labels": {"Category: Public Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8648397"}, {"db": "pii", "key": "S0002-9378(21)01231-X"}], "notes": [], "created": "2021-11-26T14:28:58.085Z", "modified": "2023-01-13T14:47:21.250Z"}, {"entity": "publication", "iuid": "31e069a32bd145999c09803302272995", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/31e069a32bd145999c09803302272995.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/31e069a32bd145999c09803302272995"}}, "title": "Patient and public involvement in the build-up of COVID-19 testing in Sweden.", "authors": [{"family": "Fredriksson", "given": "Mio", "initials": "M", "orcid": "0000-0002-3858-3454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f57456b169b544b2889ddf447163756b.json"}}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Health Expect", "issn": "1369-7625", "volume": "25", "issue": "2", "pages": "541-548", "issn-l": null}, "abstract": "Patient and public involvement in healthcare can be particularly challenging during crises such as the COVID-19 pandemic.\n\nThe aims of the study, which focuses on COVID-19 testing in Sweden, were to explore (1) how, or to what extent, patients and members of the public were involved in decisions about the organization of COVID-19 testing during the first year of pandemic and (2) whether this was seen as feasible or desirable by regional and national stakeholders.\n\nA qualitative interview study was conducted with key organizational stakeholders at three national agencies and within three Swedish regions (n = 16).\n\nThere had been no patient and public involvement activities in the area of COVID-19 testing. The regions had, however, tried to respond to demands or critiques from patients and the public along the way and to adapt the services to respond to their preferences. The need for rapid decision-making, the uncertainty about whom to involve, as well as a hesitation about the appropriateness of involving patients and the public contributed to the lack of involvement.\n\nFuture studies on patient and public involvement during crises should address what structures need to be in place to carry out involvement successfully during crises and when to use activities with varying degrees of power or decision-making authority for patients and members of the public.\n\nFifteen members of the public contributed with short reflections on the study findings.", "doi": "10.1111/hex.13463", "pmid": "35257448", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8957722"}], "notes": [], "created": "2023-01-13T13:32:28.458Z", "modified": "2023-01-13T13:32:28.510Z"}, {"entity": "publication", "iuid": "763b1af1aa094b39ac60e0090b487a6b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/763b1af1aa094b39ac60e0090b487a6b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/763b1af1aa094b39ac60e0090b487a6b"}}, "title": "Modeling COVID-19 Mortality Across 44 Countries: Face Covering May Reduce Deaths.", "authors": [{"family": "Motallebi", "given": "Sahar", "initials": "S"}, {"family": "Cheung", "given": "Rex C Y", "initials": "RCY"}, {"family": "Mohit", "given": "Babak", "initials": "B"}, {"family": "Shahabi", "given": "Shahram", "initials": "S"}, {"family": "Alishahi Tabriz", "given": "Amir", "initials": "A"}, {"family": "Moattari", "given": "Syamak", "initials": "S"}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Am J Prev Med", "issn": "1873-2607", "volume": "62", "issue": "4", "pages": "483-491", "issn-l": null}, "abstract": "Despite ongoing efforts to vaccinate communities against COVID-19, the necessity of face mask use in controlling the pandemic remains subject to debate. Several studies have investigated face masks and COVID-19, covering smaller and less diverse populations than this study's sample. This study examines a hypothesized association of face-covering mandates with COVID-19 mortality decline across 44 countries in 2 continents.\n\nIn a retrospective cohort study, changes in COVID-19\u2012related daily mortality rate per million population from February 15 to May 31, 2020 were compared between 27 countries with and 17 countries without face mask mandates in nearly 1 billion (911,446,220 total) people. Longitudinal mixed effect modeling was applied and adjusted for over 10 relevant demographic, social, clinical, and time-dependent confounders.\n\nAverage COVID-19 mortality per million was 288.54 in countries without face mask policies and 48.40 in countries with face mask policies. In no mask countries, adjusted average daily increase was 0.1553 - 0.0017 X (days since the first case) log deaths per million, compared with 0.0900 - 0.0009 X (days since the first case) log deaths per million in the countries with a mandate. A total of 60 days into the pandemic, countries without face mask mandates had an average daily increase of 0.0533 deaths per million, compared with the average daily increase of 0.0360 deaths per million for countries with face mask mandates.\n\nThis study's significant results show that face mask mandates were associated with lower COVID-19 deaths rates than the rates in countries without mandates. These findings support the use of face masks to prevent excess COVID-19 deaths and should be advised during airborne disease epidemics.", "doi": "10.1016/j.amepre.2021.09.019", "pmid": "35305777", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0749-3797(21)00557-2"}, {"db": "pmc", "key": "PMC8580811"}], "notes": [], "created": "2022-03-23T06:16:41.748Z", "modified": "2022-04-04T07:12:28.738Z"}, {"entity": "publication", "iuid": "c57b1b3cc1e24d3e85c9a87cf3771051", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c57b1b3cc1e24d3e85c9a87cf3771051.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c57b1b3cc1e24d3e85c9a87cf3771051"}}, "title": "Long-term SARS-CoV-2-specific and cross-reactive cellular immune responses correlate with humoral responses, disease severity, and symptomatology.", "authors": [{"family": "Laur\u00e9n", "given": "Ida", "initials": "I", "orcid": "0000-0003-0041-6084", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76b14e85b56d4c898ad853659043b3b2.json"}}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/305bca9e5c6c423898c272bf06ce2f2a.json"}}, {"family": "Lord", "given": "Martin", "initials": "M"}, {"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Gabrielsson", "given": "Lena", "initials": "L"}, {"family": "Chourlia", "given": "Aikaterini", "initials": "A"}, {"family": "Amo\u00eado-Leite", "given": "Catarina", "initials": "C"}, {"family": "Josyula", "given": "Vijay S", "initials": "VS"}, {"family": "Eltahir", "given": "Mohamed", "initials": "M"}, {"family": "Kerzeli", "given": "Iliana", "initials": "I"}, {"family": "Falk", "given": "August J", "initials": "AJ", "orcid": "0000-0002-7773-1851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40d944d7fa964f4292f10012356a2730.json"}}, {"family": "Hober", "given": "Jonathan", "initials": "J"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Wiberg", "given": "Anna", "initials": "A"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Tegel", "given": "Hanna", "initials": "H"}, {"family": "Burman", "given": "Joachim", "initials": "J"}, {"family": "Xu", "given": "Feifei", "initials": "F"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Christoffersson", "given": "Gustaf", "initials": "G"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Philipson", "given": "Mia", "initials": "M"}, {"family": "D\u00f6nnes", "given": "Pierre", "initials": "P"}, {"family": "Lindsay", "given": "Robin", "initials": "R"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Mangsbo", "given": "Sara", "initials": "S", "orcid": "0000-0002-1355-2678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cf494629d8a4f9584ada4be16dff66b.json"}}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Immun Inflamm Dis", "issn": "2050-4527", "issn-l": null, "volume": "10", "issue": "4", "pages": "e595"}, "abstract": "Cellular immune memory responses post coronavirus disease 2019 (COVID-19) have been difficult to assess due to the risks of contaminating the immune response readout with memory responses stemming from previous exposure to endemic coronaviruses. The work herein presents a large-scale long-term follow-up study investigating the correlation between symptomology and cellular immune responses four to five months post seroconversion based on a unique severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific peptide pool that contains no overlapping peptides with endemic human coronaviruses.\r\n\r\nPeptide stimulated memory T cell responses were assessed with dual interferon-gamma (IFN\u03b3) and interleukin (IL)-2 Fluorospot. Serological analyses were performed using a multiplex antigen bead array.\r\n\r\nOur work demonstrates that long-term SARS-CoV-2-specific memory T cell responses feature dual IFN\u03b3 and IL-2 responses, whereas cross-reactive memory T cell responses primarily generate IFN\u03b3 in response to SARS-CoV-2 peptide stimulation. T cell responses correlated to long-term humoral immune responses. Disease severity as well as specific COVID-19 symptoms correlated with the magnitude of the SARS-CoV-2-specific memory T cell response four to five months post seroconversion.\r\n\r\nUsing a large cohort and a SARS-CoV-2-specific peptide pool we were able to substantiate that initial disease severity and symptoms correlate with the magnitude of the SARS-CoV-2-specific memory T cell responses.", "doi": "10.1002/iid3.595", "pmid": "35349756", "labels": {"Category: Health": null, "Research Area: Vaccine": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Type: Journal article": null, "Research Area: High-throughput and high-content serology": null}, "xrefs": [], "notes": [], "created": "2022-02-06T17:26:54.809Z", "modified": "2022-10-13T13:02:04.664Z"}, {"entity": "publication", "iuid": "04e91ab5621d4bb2b45f259dc93181cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/04e91ab5621d4bb2b45f259dc93181cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/04e91ab5621d4bb2b45f259dc93181cf"}}, "title": "Experiences of children with disabilities during the COVID-19 pandemic in Sweden: a qualitative interview study.", "authors": [{"family": "F\u00e4ldt", "given": "Anna Erica", "initials": "AE", "orcid": "0000-0001-7257-8758", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96a1134c3b564ce1919f212eee8d6725.json"}}, {"family": "Klint", "given": "Filippa", "initials": "F"}, {"family": "Warner", "given": "Georgina", "initials": "G"}, {"family": "Sarkadi", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "BMJ Paediatr Open", "issn": "2399-9772", "volume": "6", "issue": "1", "issn-l": null}, "abstract": "The impact of the COVID-19 pandemic on people with disabilities has been described as a 'triple jeopardy'. Not only have they experienced the negative social impacts of disease control measures, but access to required health services has been affected, and, not least, they are at increased risk of severe outcomes from COVID-19. This study aimed to determine how children with disabilities have experienced the pandemic in Sweden and its impact on their lives.\n\nSix children (5-13 years) were interviewed via video conferencing. An interview guide was adapted based on the children's communicative abilities and included augmentative and alternative communication support. Reflective field notes were included in the analysis. The data were analysed using qualitative content analysis.\n\nTwo themes were identified: The child's knowledge of Corona raises anxiety and fear; and Boring Corona makes the child even lonelier. The children had knowledge about and were worried about COVID-19, primarily about illness and death of their grandparents. The children longed for their grandparents and other social contacts at school, and life was described as boring and lonely. Many families lacked adequate tools to communicate with their children about the pandemic.\n\nGiven adequate support, children with disabilities and communication difficulties can give insights to their unique life situations. The interviewed children reported significant impact on their life and school life. Children were worried about their grandparents based on their knowledge about the virus. The enthusiasm with which the children engaged in the interviews is testament to the need and right of all children, regardless of communicative competence, to voice their experiences.", "doi": "10.1136/bmjpo-2021-001398", "pmid": "36053617", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8983410"}, {"db": "pii", "key": "10.1136/bmjpo-2021-001398"}], "notes": [], "created": "2022-10-13T13:20:57.007Z", "modified": "2023-01-13T13:52:53.701Z"}, {"entity": "publication", "iuid": "07eaf63ecf5c47c7a76c49d678fa0c9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07eaf63ecf5c47c7a76c49d678fa0c9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07eaf63ecf5c47c7a76c49d678fa0c9c"}}, "title": "Amyloid processing in COVID\u201019\u2010associated neurological syndromes", "authors": [{"family": "Ziff", "given": "Oliver J", "initials": "OJ", "orcid": "0000-0002-1504-7245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e3814923cdb142d8b934538ba2ec107d.json"}}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0002-3579-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0ae25211e354556a737b1a23c53c6e1.json"}}, {"family": "Mehta", "given": "Puja R", "initials": "PR"}, {"family": "Brown", "given": "Rachel", "initials": "R"}, {"family": "Athauda", "given": "Dilan", "initials": "D"}, {"family": "Heaney", "given": "Judith", "initials": "J"}, {"family": "Heslegrave", "given": "Amanda J", "initials": "AJ"}, {"family": "Benedet", "given": "Andrea Lessa", "initials": "AL"}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/351fab09f6e24b9f9e6695da83947cb6.json"}}, {"family": "Checkley", "given": "Anna M", "initials": "AM"}, {"family": "Houlihan", "given": "Catherine F", "initials": "CF"}, {"family": "Gauthier", "given": "Serge", "initials": "S"}, {"family": "Rosa\u2010Neto", "given": "Pedro", "initials": "P"}, {"family": "Fox", "given": "Nick C", "initials": "NC"}, {"family": "Schott", "given": "Jonathan M", "initials": "JM"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e314740b02c344d2b336a9410e28041e.json"}}, {"family": "Benjamin", "given": "Laura A", "initials": "LA", "orcid": "0000-0002-9685-1664", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15ffcba9a1b94d2d9d33c533c03a23d5.json"}}, {"family": "Paterson", "given": "Ross W", "initials": "RW", "orcid": "0000-0001-9372-3635", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/953284bd6f6b4bcb8fa1bb46644357ed.json"}}], "type": "journal-article", "published": "2022-04-00", "journal": {"title": "J Neurochem", "issn": "0022-3042", "issn-l": null, "volume": "161", "issue": "2", "pages": "146-157"}, "abstract": "SARS-CoV-2 infection can damage the nervous system with multiple neurological manifestations described. However, there is limited understanding of the mechanisms underlying COVID-19 neurological injury. This is a cross-sectional exploratory prospective biomarker cohort study of 21 patients with COVID-19 neurological syndromes (Guillain-Barre Syndrome [GBS], encephalitis, encephalopathy, acute disseminated encephalomyelitis [ADEM], intracranial hypertension, and central pain syndrome) and 23 healthy COVID-19 negative controls. We measured cerebrospinal fluid (CSF) and serum biomarkers of amyloid processing, neuronal injury (neurofilament light), astrocyte activation (GFAp), and neuroinflammation (tissue necrosis factor [TNF] \u0251, interleukin [IL]-6, IL-1\u03b2, IL-8). Patients with COVID-19 neurological syndromes had significantly reduced CSF soluble amyloid precursor protein (sAPP)-\u0251 (p = 0.004) and sAPP\u03b2 (p = 0.03) as well as amyloid \u03b2 (A\u03b2) 40 (p = 5.2 \u00d7 10-8 ), A\u03b242 (p = 3.5 \u00d7 10-7 ), and A\u03b242/A\u03b240 ratio (p = 0.005) compared to controls. Patients with COVID-19 neurological syndromes showed significantly increased neurofilament light (NfL, p = 0.001) and this negatively correlated with sAPP\u0251 and sAPP\u03b2. Conversely, GFAp was significantly reduced in COVID-19 neurological syndromes (p = 0.0001) and this positively correlated with sAPP\u0251 and sAPP\u03b2. COVID-19 neurological patients also displayed significantly increased CSF proinflammatory cytokines and these negatively correlated with sAPP\u0251 and sAPP\u03b2. A sensitivity analysis of COVID-19-associated GBS revealed a non-significant trend toward greater impairment of amyloid processing in COVID-19 central than peripheral neurological syndromes. This pilot study raises the possibility that patients with COVID-19-associated neurological syndromes exhibit impaired amyloid processing. Altered amyloid processing was linked to neuronal injury and neuroinflammation but reduced astrocyte activation.", "doi": "10.1111/jnc.15585", "pmid": "35137414", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC9115071"}], "notes": [], "created": "2022-02-11T10:25:39.664Z", "modified": "2023-06-19T07:47:56.235Z"}, {"entity": "publication", "iuid": "83e75c24a2244523a1c138ab61c9f01a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/83e75c24a2244523a1c138ab61c9f01a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/83e75c24a2244523a1c138ab61c9f01a"}}, "title": "Vaccine based on folded RBD-PreS fusion protein with potential to induce sterilizing immunity to SARS-CoV-2 variants.", "authors": [{"family": "Gattinger", "given": "Pia", "initials": "P", "orcid": "0000-0001-6724-8543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d470813c45d04ab295b0df1b02d7cf93.json"}}, {"family": "Kratzer", "given": "Bernhard", "initials": "B", "orcid": "0000-0003-1091-4327", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dde68da106534c85a2fdba7bf06ce4ee.json"}}, {"family": "Tulaeva", "given": "Inna", "initials": "I", "orcid": "0000-0002-5825-2687", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34ba6b200b4540579cc8f5d732832076.json"}}, {"family": "Niespodziana", "given": "Katarzyna", "initials": "K", "orcid": "0000-0003-0700-965X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f98f53416c6439f87513dd4915f2a32.json"}}, {"family": "Ohradanova-Repic", "given": "Anna", "initials": "A", "orcid": "0000-0002-8005-8522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05059e6a105642238652352cc49b5a8b.json"}}, {"family": "Gebetsberger", "given": "Laura", "initials": "L", "orcid": "0000-0002-6480-6228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/397733c00f074e479edb225c45a62363.json"}}, {"family": "Borochova", "given": "Kristina", "initials": "K"}, {"family": "Garner-Spitzer", "given": "Erika", "initials": "E", "orcid": "0000-0002-5283-0458", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/439c4225d3da443d91bb45cb87436042.json"}}, {"family": "Trapin", "given": "Doris", "initials": "D"}, {"family": "Hofer", "given": "Gerhard", "initials": "G"}, {"family": "Keller", "given": "Walter", "initials": "W", "orcid": "0000-0002-2261-958X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24a27b24c2ad4b1883a0805fd97f0b58.json"}}, {"family": "Baumgartner", "given": "Isabella", "initials": "I"}, {"family": "Tancevski", "given": "Ivan", "initials": "I", "orcid": "0000-0001-5116-8960", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb82e679725d48748424895e3fef8fa8.json"}}, {"family": "Khaitov", "given": "Musa", "initials": "M", "orcid": "0000-0003-4961-9640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d6ec5145c294afaac62bef394042c9f.json"}}, {"family": "Karaulov", "given": "Alexander", "initials": "A"}, {"family": "Stockinger", "given": "Hannes", "initials": "H", "orcid": "0000-0001-6404-4430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/134cb6399ed043879f4f834914429698.json"}}, {"family": "Wiedermann", "given": "Ursula", "initials": "U", "orcid": "0000-0002-1302-3223", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ecada0958ed84f0186e48880c874ad07.json"}}, {"family": "Pickl", "given": "Winfried F", "initials": "WF", "orcid": "0000-0003-0430-4952", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/efd20aea311c46f7ad4a2930a5308a8c.json"}}, {"family": "Valenta", "given": "Rudolf", "initials": "R", "orcid": "0000-0001-5944-3365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46fbb364a1fd41c4a2d48836789dfd4c.json"}}], "type": "journal article", "published": "2022-03-31", "journal": {"title": "Allergy", "issn": "1398-9995", "issn-l": "0105-4538"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing global COVID-19 pandemic. One possibility to control the pandemic is to induce sterilizing immunity through the induction and maintenance of neutralizing antibodies preventing SARS-CoV-2 from entering human cells to replicate in.\n\nWe report the construction and in vitro and in vivo characterization of a SARS-CoV-2 subunit vaccine (PreS-RBD) based on a structurally folded recombinant fusion protein consisting of two SARS-CoV-2 Spike protein receptor-binding domains (RBD) fused to the N- and C-terminus of hepatitis B virus (HBV) surface antigen PreS to enable the two unrelated proteins serving as immunologic carriers for each other.\n\nPreS-RBD, but not RBD alone, induced a robust and uniform RBD-specific IgG response in rabbits. Currently available genetic SARS-CoV-2 vaccines induce mainly transient IgG1 responses in vaccinated subjects whereas the PreS-RBD vaccine induced RBD-specific IgG antibodies consisting of an early IgG1 and sustained IgG4 antibody response in a SARS-CoV-2 naive subject. PreS-RBD-specific IgG antibodies were detected in serum and mucosal secretions, reacted with SARS-CoV-2 variants, including the omicron variant of concern and the HBV receptor-binding sites on PreS of currently known HBV genotypes. PreS-RBD-specific antibodies of the immunized subject more potently inhibited the interaction of RBD with its human receptor ACE2 and their virus-neutralizing titers (VNTs) were higher than median VNTs in a random sample of healthy subjects fully immunized with registered SARS-CoV-2 vaccines or in COVID-19 convalescent subjects.\n\nThe PreS-RBD vaccine has the potential to serve as a combination vaccine for inducing sterilizing immunity against SARS-CoV-2 and HBV by stopping viral replication through the inhibition of cellular virus entry.", "doi": "10.1111/all.15305", "pmid": "35357709", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC9111473"}], "notes": [], "created": "2022-04-04T06:34:40.717Z", "modified": "2022-06-21T18:21:30.822Z"}, {"entity": "publication", "iuid": "6e24f7cb3e584302898f650734b1a74a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e24f7cb3e584302898f650734b1a74a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e24f7cb3e584302898f650734b1a74a"}}, "title": "Long-term outcomes of dexamethasone 12 mg versus 6 mg in patients with COVID-19 and severe hypoxaemia.", "authors": [{"family": "Granholm", "given": "Anders", "initials": "A"}, {"family": "Kj\u00e6r", "given": "Maj-Brit N\u00f8rregaard", "initials": "MN"}, {"family": "Munch", "given": "Marie Warrer", "initials": "MW"}, {"family": "Myatra", "given": "Sheila Nainan", "initials": "SN"}, {"family": "Vijayaraghavan", "given": "Bharath Kumar Tirupakuzhi", "initials": "BKT"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Wahlin", "given": "Rebecka Rubenson", "initials": "RR"}, {"family": "Jakob", "given": "Stephan M", "initials": "SM"}, {"family": "Cioccari", "given": "Luca", "initials": "L"}, {"family": "Vesterlund", "given": "Gitte Kingo", "initials": "GK"}, {"family": "Meyhoff", "given": "Tine Sylvest", "initials": "TS"}, {"family": "Helleberg", "given": "Marie", "initials": "M"}, {"family": "M\u00f8ller", "given": "Morten Hylander", "initials": "MH"}, {"family": "Benfield", "given": "Thomas", "initials": "T"}, {"family": "Venkatesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Hammond", "given": "Naomi E", "initials": "NE"}, {"family": "Micallef", "given": "Sharon", "initials": "S"}, {"family": "Bassi", "given": "Abhinav", "initials": "A"}, {"family": "John", "given": "Oommen", "initials": "O"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Kristiansen", "given": "Klaus Tjelle", "initials": "KT"}, {"family": "Ulrik", "given": "Charlotte Suppli", "initials": "CS"}, {"family": "J\u00f8rgensen", "given": "Vibeke Lind", "initials": "VL"}, {"family": "Smitt", "given": "Margit", "initials": "M"}, {"family": "Bestle", "given": "Morten H", "initials": "MH"}, {"family": "Andreasen", "given": "Anne Sofie", "initials": "AS"}, {"family": "Poulsen", "given": "Lone Musaeus", "initials": "LM"}, {"family": "Rasmussen", "given": "Bodil Steen", "initials": "BS"}, {"family": "Br\u00f8chner", "given": "Anne Craveiro", "initials": "AC"}, {"family": "Str\u00f8m", "given": "Thomas", "initials": "T"}, {"family": "M\u00f8ller", "given": "Anders", "initials": "A"}, {"family": "Khan", "given": "Mohd Saif", "initials": "MS"}, {"family": "Padmanaban", "given": "Ajay", "initials": "A"}, {"family": "Divatia", "given": "Jigeeshu Vasishtha", "initials": "JV"}, {"family": "Saseedharan", "given": "Sanjith", "initials": "S"}, {"family": "Borawake", "given": "Kapil", "initials": "K"}, {"family": "Kapadia", "given": "Farhad", "initials": "F"}, {"family": "Dixit", "given": "Subhal", "initials": "S"}, {"family": "Chawla", "given": "Rajesh", "initials": "R"}, {"family": "Shukla", "given": "Urvi", "initials": "U"}, {"family": "Amin", "given": "Pravin", "initials": "P"}, {"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Wamberg", "given": "Christian Aage", "initials": "CA"}, {"family": "Bose", "given": "Neeta", "initials": "N"}, {"family": "Shah", "given": "Mehul S", "initials": "MS"}, {"family": "Darfelt", "given": "Iben S", "initials": "IS"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Lange", "given": "Theis", "initials": "T"}, {"family": "Perner", "given": "Anders", "initials": "A", "orcid": "0000-0002-4668-0123", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5d5120bc69c433f9df2b929d6be905a.json"}}], "type": "journal article", "published": "2022-03-31", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "issn-l": "0342-4642"}, "abstract": "We assessed long-term outcomes of dexamethasone 12 mg versus 6 mg given daily for up to 10 days in patients with coronavirus disease 2019 (COVID-19) and severe hypoxaemia.\n\nWe assessed 180-day mortality and health-related quality of life (HRQoL) using EuroQoL (EQ)-5D-5L index values and EQ visual analogue scale (VAS) in the international, stratified, blinded COVID STEROID 2 trial, which randomised 1000 adults with confirmed COVID-19 receiving at least 10 L/min of oxygen or mechanical ventilation in 26 hospitals in Europe and India. In the HRQoL analyses, higher values indicated better outcomes, and deceased patients were given a score of zero.\n\nWe obtained vital status at 180 days for 963 of 982 patients (98.1%) in the intention-to-treat population, EQ-5D-5L index value data for 922 (93.9%) and EQ VAS data for 924 (94.1%). At 180 days, 164 of 486 patients (33.7%) had died in the 12 mg group versus 184 of 477 (38.6%) in the 6 mg group [adjusted risk difference - 4.3%; 99% confidence interval (CI) - 11.7-3.0; relative risk 0.89; 0.72-1.09; P = 0.13]. The adjusted mean differences between the 12 mg and the 6 mg groups in EQ-5D-5L index values were 0.06 (99% CI - 0.01 to 0.12; P = 0.10) and in EQ VAS scores 4 (- 3 to 10; P = 0.22).\n\nAmong patients with COVID-19 and severe hypoxaemia, dexamethasone 12 mg compared with 6 mg did not result in statistically significant improvements in mortality or HRQoL at 180 days, but the results were most compatible with benefit from the higher dose.", "doi": "10.1007/s00134-022-06677-2", "pmid": "35359168", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-022-06677-2"}, {"db": "pmc", "key": "PMC8970069"}, {"db": "ClinicalTrials.gov", "key": "NCT04509973"}], "notes": [], "created": "2022-04-04T06:33:48.635Z", "modified": "2022-04-04T06:34:05.700Z"}, {"entity": "publication", "iuid": "18980b26d5f84f00b2e0b6e40b94d549", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18980b26d5f84f00b2e0b6e40b94d549.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18980b26d5f84f00b2e0b6e40b94d549"}}, "title": "Impact of the COVID-19 pandemic on subcutaneous venous port-related complications in patients with cancer: a retrospective case-control study.", "authors": [{"family": "Dahlin", "given": "Linnea", "initials": "L", "orcid": "0000-0002-8888-6103", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8dd7b90b88c34a168048b508c6f883b1.json"}}, {"family": "Taxbro", "given": "Knut", "initials": "K"}, {"family": "Hammarskj\u00f6ld", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2022-03-31", "journal": {"title": "World J Surg Oncol", "issn": "1477-7819", "volume": "20", "issue": "1", "pages": "103", "issn-l": null}, "abstract": "Vascular access in cancer patients is of great importance in order to deliver tumour-specific therapy and continues to be so during exceptional conditions. This study aimed to examine the impact of the coronavirus disease 2019 pandemic on the care and complication rates associated with subcutaneous venous port (PORT) insertion in cancer treatment.\n\nWe retrospectively studied all adult cancer patients that received a PORT in 2020 at a Swedish county hospital, including insertion characteristics and in-dwell complication rates for up to 6 months after implantation; these estimates were compared with historic data.\n\nData from 257 patients, of which 56 were haematological patients, were included and compared with those of 168 patients in the control group. The group characteristics were similar, except for the inclusion of haematological patients in the study group. Insertion characteristics showed a shorter waiting time and higher rates of antibiotic and sedative use during the pandemic. The rates of postoperative haematoma and catheter occlusion during the study period were higher than otherwise. The rates of adverse events related to the PORT in the solid tumour group were comparable to those in the control group (18.4% vs. 14.9%). Patients with haematological malignancies were more likely to experience adverse events (37.5% vs. 18.4%) and deep venous thrombosis (7.1% vs. 1.0%) than those with solid tumours.\n\nIn conclusion, the present findings suggest that PORTs remain a safe venous access system even during a pandemic, indicating a robust vascular access service.", "doi": "10.1186/s12957-022-02568-4", "pmid": "35354461", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12957-022-02568-4"}, {"db": "pmc", "key": "PMC8967566"}], "notes": [], "created": "2022-04-04T06:35:00.532Z", "modified": "2022-04-04T06:35:10.622Z"}, {"entity": "publication", "iuid": "0b309d7eb77b4a2eb072680743bb7a12", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b309d7eb77b4a2eb072680743bb7a12.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b309d7eb77b4a2eb072680743bb7a12"}}, "title": "Validation of the Canadian French version of the fear of COVID-19 scale in the general population of Quebec.", "authors": [{"family": "Attieh", "given": "Randa", "initials": "R"}, {"family": "Koffi", "given": "Kouam\u00e9", "initials": "K"}, {"family": "Tour\u00e9", "given": "Moustapha", "initials": "M", "orcid": "0000-0002-7640-0356", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b5b37d4661e49d090af2f83a0061f8b.json"}}, {"family": "Parr-Labb\u00e9", "given": "\u00c9rica", "initials": "\u00c9"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}, {"family": "Poder", "given": "Thomas G", "initials": "TG"}], "type": "journal article", "published": "2022-03-30", "journal": {"title": "Brain Behav", "issn": "2162-3279", "pages": "e32550", "issn-l": null}, "abstract": "The purpose of this study was to develop a Canadian French translation of the fear of COVID-19 scale (FCV-19S) and assess its psychometric characteristics.\n\nA forward and backtranslation process was conducted for the Canadian French version of the FCV-19S. The guidance of the ISPOR task force for translation and cultural adaptation was followed and cognitive debriefing interviews were conducted with six citizens. The final proofread Canadian French FCV-19S was then administered to a large sample of citizens from the province of Quebec in Canada through an online survey. A quota sampling was conducted in 2020. Respondents from the survey also completed the Clinical Outcomes in Routine Evaluation (CORE)-6D and the Sense of Coherence (SOC-3) questionnaires. Several psychometric tests were performed to investigate the reliability (internal consistency) and validity of the Canadian French FCV-19S, including construct validity, concurrent validity, and Rasch analysis.\n\nThe translation process was conducted without any major difficulties. The cognitive debriefing interviews led to no change in the reconciled translation. The survey collected answers from 3428 citizens. Results indicated that the factor structure of the Canadian French FCV-19S is a unidimensional factor fitting well with the data. The scale showed adequate reliability (Cronbach's alpha of .903) and concurrent validity, as indicated by significantly negative correlation with CORE-6D (r = -.410) and SOC-3 (r = -.233). The Canadian French FCV-19S properties tested using Rasch analysis was also very satisfactory.\n\nThe results of the present study indicated that the Canadian French version of FCV-19S is a unidimensional tool with robust psychometric properties in the adult's population of all ages residing in the province of Quebec, Canada.", "doi": "10.1002/brb3.2550", "pmid": "35353955", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-04-04T06:35:37.045Z", "modified": "2022-04-04T06:35:37.121Z"}, {"entity": "publication", "iuid": "2cf3de26096e435d8fd40a28afe2228b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2cf3de26096e435d8fd40a28afe2228b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2cf3de26096e435d8fd40a28afe2228b"}}, "title": "We're on mute! Exclusion of nurses' voices in national decisions and responses to COVID-19: An international perspective.", "authors": [{"family": "Rasmussen", "given": "Bodil", "initials": "B", "orcid": "0000-0002-6789-8260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24463789a4fa42f88a120f098ce640e0.json"}}, {"family": "Holton", "given": "Sara", "initials": "S", "orcid": "0000-0001-9294-7872", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64829fda675a413fbb2b7fedb14f37a9.json"}}, {"family": "Wynter", "given": "Karen", "initials": "K", "orcid": "0000-0003-4620-7691", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a09500b4fc034472b2d89d898f9ac75e.json"}}, {"family": "Phillips", "given": "David J", "initials": "DJ"}, {"family": "David", "given": "Jennifer L", "initials": "JL", "orcid": "0000-0001-6297-6429", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/755ec5167d52464cba85ebeb62bf8dd2.json"}}, {"family": "Rothmann", "given": "Mette Juel", "initials": "MJ", "orcid": "0000-0001-6505-4163", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4fc0ce619c694a1fbd6cd042105bb3b9.json"}}, {"family": "Skjoeth", "given": "Mette Maria", "initials": "MM", "orcid": "0000-0002-3528-4619", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa8742bfe09d4ea2be9f287ff3af0d72.json"}}, {"family": "Wijk", "given": "Helle", "initials": "H", "orcid": "0000-0001-8799-6856", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d845c2268c748dba1348a56f2b82589.json"}}, {"family": "Frederiksen", "given": "Kirsten", "initials": "K", "orcid": "0000-0002-2082-7094", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/938fbb5dfb1b45329e124f17cedee58e.json"}}, {"family": "Ahlstrom", "given": "Linda", "initials": "L", "orcid": "0000-0002-3372-8722", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f026139e64a84dfe9de9cd89aca4f6f7.json"}}, {"family": "Anderson", "given": "Janet E", "initials": "JE", "orcid": "0000-0002-1452-8370", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7fde0f4a4b24d6c8e1d934b30915757.json"}}, {"family": "Harris", "given": "Ruth", "initials": "R", "orcid": "0000-0002-4377-5063", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/635193f5f85f4f62b922411377749704.json"}}, {"family": "Conolly", "given": "Anna", "initials": "A", "orcid": "0000-0002-0747-4597", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4573b079b6cc450dbe271a6bcce1ebf9.json"}}, {"family": "Kent", "given": "Bridie", "initials": "B", "orcid": "0000-0001-9550-1913", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef4f521d21324590bfe3618a30a885c8.json"}}, {"family": "Maben", "given": "Jill", "initials": "J", "orcid": "0000-0002-6168-0455", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a3518673bd24747844fff98628584e0.json"}}], "type": "editorial", "published": "2022-03-29", "journal": {"title": "J Adv Nurs", "issn": "1365-2648", "issn-l": null}, "abstract": null, "doi": "10.1111/jan.15236", "pmid": "35352392", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9111388"}], "notes": [], "created": "2022-04-04T06:36:00.777Z", "modified": "2022-06-21T18:21:06.170Z"}, {"entity": "publication", "iuid": "eb0a8f3e367944d58d8598c523376c6f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb0a8f3e367944d58d8598c523376c6f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb0a8f3e367944d58d8598c523376c6f"}}, "title": "Impacts of changes in environmental exposures and health behaviours due to the COVID-19 pandemic on cardiovascular and mental health: A comparison of Barcelona, Vienna, and Stockholm.", "authors": [{"family": "Koch", "given": "Sarah", "initials": "S"}, {"family": "Khomenko", "given": "Sasha", "initials": "S"}, {"family": "Cirach", "given": "Marta", "initials": "M"}, {"family": "Ubalde-Lopez", "given": "M\u00f2nica", "initials": "M"}, {"family": "Baclet", "given": "Sacha", "initials": "S"}, {"family": "Daher", "given": "Carolyn", "initials": "C"}, {"family": "Hidalgo", "given": "Laura", "initials": "L"}, {"family": "L\u00f5hmus", "given": "Mare", "initials": "M"}, {"family": "Rizzuto", "given": "Debora", "initials": "D"}, {"family": "Rumpler", "given": "Romain", "initials": "R"}, {"family": "Susilo", "given": "Yusak", "initials": "Y"}, {"family": "Venkataraman", "given": "Siddharth", "initials": "S"}, {"family": "Wegener", "given": "Sandra", "initials": "S"}, {"family": "Wellenius", "given": "Gregory A", "initials": "GA"}, {"family": "Woodcock", "given": "James", "initials": "J"}, {"family": "Nieuwenhuijsen", "given": "Mark", "initials": "M"}], "type": "journal article", "published": "2022-03-29", "journal": {"title": "Environ Pollut", "issn": "1873-6424", "pages": "119124", "issn-l": null}, "abstract": "Responses to COVID-19 altered environmental exposures and health behaviours associated with non-communicable diseases. We aimed to (1) quantify changes in nitrogen dioxide (NO2), noise, physical activity, and greenspace visits associated with COVID-19 policies in the spring of 2020 in Barcelona (Spain), Vienna (Austria), and Stockholm (Sweden), and (2) estimated the number of additional and prevented diagnoses of myocardial infarction (MI), stroke, depression, and anxiety based on these changes. We calculated differences in NO2, noise, physical activity, and greenspace visits between pre-pandemic (baseline) and pandemic (counterfactual) levels. With two counterfactual scenarios, we distinguished between Acute Period (March 15th - April 26th, 2020) and Deconfinement Period (May 2nd - June 30th, 2020) assuming counterfactual scenarios were extended for 12 months. Relative risks for each exposure difference were estimated with exposure-risk functions. In the Acute Period, reductions in NO2 (range of change from -16.9 \u03bcg/m3 to -1.1 \u03bcg/m3), noise (from -5 dB(A) to -2 dB(A)), physical activity (from -659 MET*min/wk to -183 MET*min/wk) and greenspace visits (from -20.2 h/m to 1.1 h/m) were largest in Barcelona and smallest in Stockholm. In the Deconfinement Period, NO2 (from -13.9 \u03bcg/m3 to -3.1 \u03bcg/m3), noise (from -3 dB(A) to -1 dB(A)), and physical activity levels (from -524 MET*min/wk to -83 MET*min/wk) remained below pre-pandemic levels in all cities. Greatest impacts were caused by physical activity reductions. If physical activity levels in Barcelona remained at Acute Period levels, increases in annual diagnoses for MI (mean: 572 (95% CI: 224, 943)), stroke (585 (6, 1156)), depression (7903 (5202, 10,936)), and anxiety (16,677 (926, 27,002)) would be anticipated. To decrease cardiovascular and mental health impacts, reductions in NO2 and noise from the first COVID-19 surge should be sustained, but without reducing physical activity. Focusing on cities' connectivity that promotes active transportation and reduces motor vehicle use assists in achieving this goal.", "doi": "10.1016/j.envpol.2022.119124", "pmid": "35367103", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0269-7491(22)00338-4"}], "notes": [], "created": "2022-04-04T06:21:29.659Z", "modified": "2022-04-04T06:21:29.689Z"}, {"entity": "publication", "iuid": "60101c2caae04a6f89bc2b6dbcaed531", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60101c2caae04a6f89bc2b6dbcaed531.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60101c2caae04a6f89bc2b6dbcaed531"}}, "title": "Self-reported mental health status of pregnant women in Sweden during the COVID-19 pandemic: a cross-sectional survey.", "authors": [{"family": "Ho-Fung", "given": "Chung", "initials": "C"}, {"family": "Andersson", "given": "Ewa", "initials": "E"}, {"family": "Hsuan-Ying", "given": "Huang", "initials": "H"}, {"family": "Acharya", "given": "Ganesh", "initials": "G", "orcid": "0000-0002-1997-3107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d1c2ac0dfb849d8b2374451e38cdcba.json"}}, {"family": "Schwank", "given": "Simone", "initials": "S"}], "type": "journal article", "published": "2022-03-28", "journal": {"title": "BMC Pregnancy Childbirth", "issn": "1471-2393", "volume": "22", "issue": "1", "pages": "260", "issn-l": null}, "abstract": "The COVID-19 pandemic has contributed to unprecedented worries and challenges for pregnant women due to social restrictions and changes in maternity care provision. We aimed to investigate the mental health impact of COVID-19 pandemic on pregnant women in Sweden and explore factors associated with poor perinatal mental health in this specific context.\n\nThis was a nation-wide cross-sectional survey of pregnant women living in Sweden. Validated questionnaires were distributed through non-profit organizations\u00b4 websites and social media channels from May 2020 to February 2021. Perinatal depression, anxiety, and acute stress reaction were assessed using the Edinburgh Postnatal Depression Scale (EPDS), Generalized Anxiety Disorder-7 (GAD-7) and Impact Event Scale (Revised) (IES-R), respectively. Sociodemographic characteristics and self-perceived mental well-being were also obtained. Factors associated with mental health outcomes were analyzed using multivariate logistic regression model.\n\nAmong a total of 470 participants, 43.2% (n = 203) reported depression (EPDS \u226513), 25.7% (n = 121) moderate to severe anxiety (GAD-7 score \u2265 10), and 23.7% (n = 110) moderate to severe acute stress reaction (IES-R \u2265 33). 27.4% participants (n = 129) expressed concerns regarding their mental well-being during the pandemic. Pregnant mothers who had sick family members reported poorer mental health outcomes than those who did not (median [Interquartile range (IQR)] EPDS scores: 14.0 [8.75-18.0] vs 11.0 [6.25-15.0], p < .001; median (IQR) GAD7 scores: 7.0 [4.0-12.25] vs 6.0 [3.0-9.0], p = .003); median (IQR) IES-R scores: 20.0 [9.0-38.0] vs 15.0 [7.0-30.0], p = .048). Logistic regression analyses revealed that risk factors for poor mental health outcomes were having a sick family member with any illness, unemployment, and experiencing a substantially stressful life event. Having a higher educational level and a younger age during the pandemic were protective.\n\nDepression and anxiety were highly prevalent among pregnant women in Sweden during the COVID-19 pandemic, indicating a need for professional mental health support for this vulnerable group of population. Unemployment was an associated risk factor whereas younger age and higher educational level were protective suggesting an important role of socio-economic factors in modulating the impact of COVID-19 pandemic on perinatal mental health.", "doi": "10.1186/s12884-022-04553-x", "pmid": "35351030", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12884-022-04553-x"}, {"db": "pmc", "key": "PMC8960205"}], "notes": [], "created": "2022-04-04T06:36:23.404Z", "modified": "2022-04-04T06:36:23.439Z"}, {"entity": "publication", "iuid": "c2a1cee2d065457ba3ed30b21ec49f01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2a1cee2d065457ba3ed30b21ec49f01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2a1cee2d065457ba3ed30b21ec49f01"}}, "title": "The Karolinska NeuroCOVID study protocol: Neurocognitive impairment, biomarkers and advanced imaging in critical care survivors.", "authors": [{"family": "Nelson", "given": "David W", "initials": "DW"}, {"family": "Granberg", "given": "Tobias", "initials": "T"}, {"family": "Andersen", "given": "Pia", "initials": "P"}, {"family": "Jokhadar", "given": "Elias", "initials": "E"}, {"family": "K\u00e5hlin", "given": "Jessica", "initials": "J"}, {"family": "Granstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Hallinder", "given": "Helena", "initials": "H"}, {"family": "Schening", "given": "Anna", "initials": "A"}, {"family": "Thunborg", "given": "Charlotta", "initials": "C"}, {"family": "Walles", "given": "H\u00e5kan", "initials": "H"}, {"family": "Hagman", "given": "G\u00f6ran", "initials": "G"}, {"family": "Shams-Latifi", "given": "Roya", "initials": "R"}, {"family": "Yu", "given": "Jimmy", "initials": "J"}, {"family": "Petersson", "given": "Sven", "initials": "S"}, {"family": "Tzortzakakis", "given": "Antonios", "initials": "A"}, {"family": "Levak", "given": "Nicholas", "initials": "N"}, {"family": "Asp\u00f6", "given": "Malin", "initials": "M"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}], "type": "journal article", "published": "2022-03-25", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172"}, "abstract": "This is the study plan of the Karolinska NeuroCOVID study, a study of neurocognitive impairment after severe COVID-19, relating post-intensive care unit (ICU) cognitive and neurological deficits to biofluid markers and MRI. The COVID-19 pandemic has posed enormous health challenges to individuals and health-care systems worldwide. An emerging feature of severe COVID-19 is that of temporary and extended neurocognitive impairment, exhibiting a myriad of symptoms and signs. The causes of this symptomatology have not yet been fully elucidated.\n\nIn this study, we aim to investigate patients treated for severe COVID-19 in the ICU, as to describe and relate serum-, plasma- and cerebrospinal fluid-borne molecular and cellular biomarkers of immune activity, coagulopathy, cerebral damage, neuronal inflammation, and degeneration, to the temporal development of structural and functional changes within the brain as evident by serial MRI and extensive cognitive assessments at 3-12 months after ICU discharge.\n\nTo date, we have performed 51 3-month follow-up MRIs in the ICU survivors. Of these, two patients (~4%) have had incidental findings on brain MRI findings requiring activation of the Incidental Findings Management Plan. Furthermore, the neuropsychological and neurological examinations have so far revealed varying and mixed patterns. Several patients expressed cognitive and/or mental concerns and fatigue, complaints closely related to brain fog.\n\nThe study goal is to gain a better understanding of the pathological mechanisms and neurological consequences of this new disease, with a special emphasis on neurodegenerative and neuroinflammatory processes, in order to identify targets of intervention and rehabilitation.", "doi": "10.1111/aas.14062", "pmid": "35332517", "labels": {"Category: Health": null, "Funder: VR": null, "Category: Biochemistry": null, "Funder: Forte": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-04-04T06:58:30.523Z", "modified": "2022-04-04T06:58:30.537Z"}, {"entity": "publication", "iuid": "3e554caa8e4348698c04b63cadcfdf08", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3e554caa8e4348698c04b63cadcfdf08.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3e554caa8e4348698c04b63cadcfdf08"}}, "title": "Outcomes of SARS-CoV-2 infection among children and young people with pre-existing rheumatic and musculoskeletal diseases.", "authors": [{"family": "Kearsley-Fleet", "given": "Lianne", "initials": "L", "orcid": "0000-0003-0377-1575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9cc64aac266462baf67998b3d49c6f7.json"}}, {"family": "Chang", "given": "Min-Lee", "initials": "ML", "orcid": "0000-0001-9868-4030", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b28b0d9449d40d4a5eb1580a78f02b7.json"}}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S", "orcid": "0000-0002-8611-162X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73b17eb08d984421847f733b7a6a49d4.json"}}, {"family": "Costello", "given": "Ruth", "initials": "R", "orcid": "0000-0003-2709-6666", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c0fe69f61b54ab89f9a3de852f872a8.json"}}, {"family": "Fingerhutov\u00e1", "given": "\u0160\u00e1rka", "initials": "\u0160", "orcid": "0000-0003-2170-2688", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a96659bf4264bf799ef50ecae0c8b37.json"}}, {"family": "\u0160vestkov\u00e1", "given": "Nat\u00e1lie", "initials": "N"}, {"family": "Belot", "given": "Alexandre", "initials": "A", "orcid": "0000-0003-4902-5332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbf2b4fa1aa14e359603cfc5fdf38439.json"}}, {"family": "Aeschlimann", "given": "Florence A", "initials": "FA", "orcid": "0000-0001-7212-9151", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fd044aff5324e22a42e0d90d2edbfea.json"}}, {"family": "Melki", "given": "Isabelle", "initials": "I", "orcid": "0000-0002-8057-333X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48f0d34d38644394a0707b1bd62d3c0e.json"}}, {"family": "Kon\u00e9-Paut", "given": "Isabelle", "initials": "I", "orcid": "0000-0001-8939-5763", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18d5124274b34a10a72a755258035099.json"}}, {"family": "Eulert", "given": "Sascha", "initials": "S", "orcid": "0000-0002-7921-708X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37cbd77e83b04c82a9b6343afcdc5c83.json"}}, {"family": "Kallinich", "given": "Tilmann", "initials": "T", "orcid": "0000-0003-2404-9397", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b028eb778594e95ade00b6e18fc6bc6.json"}}, {"family": "Berkun", "given": "Yackov", "initials": "Y", "orcid": "0000-0001-9823-4750", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32ae7278290547c58db4994ff2b9c621.json"}}, {"family": "Uziel", "given": "Yosef", "initials": "Y", "orcid": "0000-0003-4655-1652", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d555727f6aa482891e28b936a5b4419.json"}}, {"family": "Raffeiner", "given": "Bernd", "initials": "B", "orcid": "0000-0002-7719-1736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9593bcad2ce747e3a65e7160559e3f5e.json"}}, {"family": "Oliveira Ramos", "given": "Filipa", "initials": "F"}, {"family": "Clemente", "given": "Daniel", "initials": "D", "orcid": "0000-0002-1605-7488", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6527b4ae3e38472cafc253c6e0155dda.json"}}, {"family": "Dackhammar", "given": "Christina", "initials": "C", "orcid": "0000-0001-9389-4282", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd9333db812c40389d8f20149efb4f2b.json"}}, {"family": "Wulffraat", "given": "Nico M", "initials": "NM", "orcid": "0000-0001-9548-5562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a14b62a27efe4966980036c8366d557c.json"}}, {"family": "Waite", "given": "Helen", "initials": "H", "orcid": "0000-0002-8435-9496", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d33974aecf224f8a89df175a5f487c56.json"}}, {"family": "Strangfeld", "given": "Anja", "initials": "A", "orcid": "0000-0002-6233-022X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/644005e83dff44b7bdca5d2b818e17d5.json"}}, {"family": "Mateus", "given": "Elsa F", "initials": "EF", "orcid": "0000-0003-0059-2141", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cbb817ab9e6e448db217bab218522259.json"}}, {"family": "Machado", "given": "Pedro M", "initials": "PM", "orcid": "0000-0002-8411-7972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef40d1eea57946e4a37d2e92a02a47cd.json"}}, {"family": "CARRA Registry Investigators", "given": "", "initials": ""}, {"family": "COVID-19 Global Pediatric Rheumatology Database Investigators", "given": "", "initials": ""}, {"family": "Natter", "given": "Marc", "initials": "M", "orcid": "0000-0003-0748-2674", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8ebb638b08546b99ae50524ac3a41d5.json"}}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL", "orcid": "0000-0001-8242-9262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9ad49b088eb467ba6d1ca1559b88047.json"}}], "type": "journal article", "published": "2022-03-25", "journal": {"title": "Ann Rheum Dis", "issn": "1468-2060", "issn-l": null}, "abstract": "Some adults with rheumatic and musculoskeletal diseases (RMDs) are at increased risk of COVID-19-related death. Excluding post-COVID-19 multisystem inflammatory syndrome of children, children and young people (CYP) are overall less prone to severe COVID-19 and most experience a mild or asymptomatic course. However, it is unknown if CYP with RMDs are more likely to have more severe COVID-19. This analysis aims to describe outcomes among CYP with underlying RMDs with COVID-19.\n\nUsing the European Alliance of Associations for Rheumatology COVID-19 Registry, the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry, and the CARRA-sponsored COVID-19 Global Paediatric Rheumatology Database, we obtained data on CYP with RMDs who reported SARS-CoV-2 infection (presumptive or confirmed). Patient characteristics and illness severity were described, and factors associated with COVID-19 hospitalisation were investigated.\n\n607 CYP with RMDs <19 years old from 25 different countries with SARS-CoV-2 infection were included, the majority with juvenile idiopathic arthritis (JIA; n=378; 62%). Forty-three (7%) patients were hospitalised; three of these patients died. Compared with JIA, diagnosis of systemic lupus erythematosus, mixed connective tissue disease, vasculitis, or other RMD (OR 4.3; 95% CI 1.7 to 11) or autoinflammatory syndrome (OR 3.0; 95% CI 1.1 to 8.6) was associated with hospitalisation, as was obesity (OR 4.0; 95% CI 1.3 to 12).\n\nThis is the most significant investigation to date of COVID-19 in CYP with RMDs. It is important to note that the majority of CYP were not hospitalised, although those with severe systemic RMDs and obesity were more likely to be hospitalised.", "doi": "10.1136/annrheumdis-2022-222241", "pmid": "35338032", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "annrheumdis-2022-222241"}], "notes": [], "created": "2022-04-04T06:50:58.842Z", "modified": "2022-04-04T06:50:59.513Z"}, {"entity": "publication", "iuid": "ffd97f47a3b54f89af1ad45af6c5ff39", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ffd97f47a3b54f89af1ad45af6c5ff39.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ffd97f47a3b54f89af1ad45af6c5ff39"}}, "title": "Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies.", "authors": [{"family": "Hanke", "given": "Leo", "initials": "L", "orcid": "0000-0001-5514-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a35f10de4f2e4aee98278f6ab845613d.json"}}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ", "orcid": "0000-0002-0227-5636", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a612a313d5874131ba64d9811a5d4a08.json"}}, {"family": "Pankow", "given": "Alec", "initials": "A", "orcid": "0000-0001-9108-1683", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a88776116034bc79c08de50a18ad39d.json"}}, {"family": "Vidakovics", "given": "Laura Perez", "initials": "LP", "orcid": "0000-0003-4283-812X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b85cf54481e94b8c95f2bf8db1038395.json"}}, {"family": "Karl", "given": "Vivien", "initials": "V", "orcid": "0000-0001-7026-7622", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d823bd5715bd46c187e252626c726e5c.json"}}, {"family": "Kim", "given": "Changil", "initials": "C", "orcid": "0000-0003-4977-4384", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d36347170c34ca386deee72faccc534.json"}}, {"family": "Urgard", "given": "Egon", "initials": "E"}, {"family": "Smith", "given": "Natalie L", "initials": "NL"}, {"family": "Astorga-Wells", "given": "Juan", "initials": "J", "orcid": "0000-0003-1017-8841", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb77d4b2e89b4662ad360a51d0061ebf.json"}}, {"family": "Ekstr\u00f6m", "given": "Simon", "initials": "S"}, {"family": "Coquet", "given": "Jonathan M", "initials": "JM", "orcid": "0000-0002-5967-4857", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ca3e4664dc444a3a992531ad3dd9201.json"}}, {"family": "McInerney", "given": "Gerald M", "initials": "GM", "orcid": "0000-0003-2257-7241", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7770437d845444a8a07865bf5b62fab0.json"}}, {"family": "Murrell", "given": "Ben", "initials": "B", "orcid": "0000-0002-0393-4445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60dac9ecf84d4eb3b90fb4ee1298bc52.json"}}], "type": "journal article", "published": "2022-03-25", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "8", "issue": "12", "pages": "eabm0220", "issn-l": "2375-2548"}, "abstract": "Conventional approaches to isolate and characterize nanobodies are laborious. We combine phage display, multivariate enrichment, next-generation sequencing, and a streamlined screening strategy to identify numerous anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nanobodies. We characterize their potency and specificity using neutralization assays and hydrogen/deuterium exchange mass spectrometry (HDX-MS). The most potent nanobodies bind to the receptor binding motif of the receptor binding domain (RBD), and we identify two exceptionally potent members of this category (with monomeric half-maximal inhibitory concentrations around 13 and 16 ng/ml). Other nanobodies bind to a more conserved epitope on the side of the RBD and are able to potently neutralize the SARS-CoV-2 founder virus (42 ng/ml), the Beta variant (B.1.351/501Y.V2) (35 ng/ml), and also cross-neutralize the more distantly related SARS-CoV-1 (0.46 \u03bcg/ml). The approach presented here is well suited for the screening of phage libraries to identify functional nanobodies for various biomedical and biochemical applications.", "doi": "10.1126/sciadv.abm0220", "pmid": "35333580", "labels": {"Category: Health": null, "Funder: VR": null, "Category: Biochemistry": null, "Type: Journal article": null, "Funder: H2020": null}, "xrefs": [], "notes": [], "created": "2022-04-04T06:57:31.249Z", "modified": "2022-04-04T06:57:31.448Z"}, {"entity": "publication", "iuid": "d547d3166d794c54b9fcc8d4e39b1fd6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d547d3166d794c54b9fcc8d4e39b1fd6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d547d3166d794c54b9fcc8d4e39b1fd6"}}, "title": "Author Correction: Self-reported COVID-19 vaccine hesitancy and uptake among participants from different racial and ethnic groups in the United States and United Kingdom.", "authors": [{"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Merino", "given": "Jordi", "initials": "J", "orcid": "0000-0001-8312-1438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12ab049914a542b39affcfb4196861d2.json"}}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Lo", "given": "Chun-Han", "initials": "CH", "orcid": "0000-0001-8202-4513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a0d9111318f4084b64f47b5b56c8c85.json"}}, {"family": "Kwon", "given": "Sohee", "initials": "S", "orcid": "0000-0002-4201-9522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/850aeda246cd44e88071b97d54b358b5.json"}}, {"family": "Wang", "given": "Kai", "initials": "K"}, {"family": "Graham", "given": "Mark S", "initials": "MS"}, {"family": "Polidori", "given": "Lorenzo", "initials": "L"}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874802ae65824a90ba50eabdeabb8356.json"}}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Anyane-Yeboa", "given": "Adjoa", "initials": "A"}, {"family": "Astley", "given": "Christina M", "initials": "CM", "orcid": "0000-0002-5063-8470", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98ce30ec7a7d45389d75aba2defce392.json"}}, {"family": "Warner", "given": "Erica T", "initials": "ET"}, {"family": "Hu", "given": "Christina Y", "initials": "CY"}, {"family": "Selvachandran", "given": "Somesh", "initials": "S"}, {"family": "Davies", "given": "Richard", "initials": "R", "orcid": "0000-0003-2050-3994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b82cc92615f462d9af0153a6fb94fde.json"}}, {"family": "Nash", "given": "Denis", "initials": "D"}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74cf1f7094744ee289fa5df041e7cb5b.json"}}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-7284-6767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeefbf47fd384d5390109fe1a903bd18.json"}}, {"family": "COPE Consortium", "given": "", "initials": ""}], "type": "published erratum", "published": "2022-03-25", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "1715", "issn-l": "2041-1723"}, "abstract": null, "doi": "10.1038/s41467-022-29100-2", "pmid": "35338133", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-022-29100-2"}, {"db": "pmc", "key": "PMC8956141"}], "notes": [], "created": "2022-04-04T06:50:41.013Z", "modified": "2022-04-04T06:50:41.134Z"}, {"entity": "publication", "iuid": "5e72d64a6f384c0aa69b85d97a5735f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e72d64a6f384c0aa69b85d97a5735f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e72d64a6f384c0aa69b85d97a5735f0"}}, "title": "A population-based cohort approach to assess excess mortality due to the spread of COVID-19 in Italy, January-May 2020.", "authors": [{"family": "Dorrucci", "given": "Maria", "initials": "M"}, {"family": "Minelli", "given": "Giada", "initials": "G"}, {"family": "Boros", "given": "Stefano", "initials": "S"}, {"family": "Manno", "given": "Valerio", "initials": "V"}, {"family": "Prati", "given": "Sabrina", "initials": "S"}, {"family": "Battaglini", "given": "Marco", "initials": "M"}, {"family": "Corsetti", "given": "Gianni", "initials": "G"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Vescio", "given": "Maria Fenicia", "initials": "MF"}, {"family": "Spuri", "given": "Matteo", "initials": "M"}, {"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Italian Integrated Surveillance COVID-19 Group", "given": "", "initials": ""}, {"family": "Italian Integrated Surveillance COVID-19 group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-03-25", "journal": {"title": "Ann Ist Super Sanita", "issn": "2384-8553", "volume": "58", "issue": "1", "pages": "25-33", "issn-l": null}, "abstract": "To assess the impact of the COVID-19 pandemic on all-cause mortality in Italy during the first wave of the epidemic, taking into consideration the geographical heterogeneity of the spread of COVID-19.\n\nThis study is a retrospective, population-based cohort study using national statistics throughout Italy. Survival analysis was applied to data aggregated by day of death, age groups, sex, and Italian administrative units (107 provinces). We applied Cox models to estimate the relative hazards (RH) of excess mortality, comparing all-cause deaths in 2020 with the expected deaths from all causes in the same time period. The RH of excess deaths was estimated in areas with a high, moderate, and low spread of COVID-19. We reported the estimate also restricting the analysis to the period of March-April 2020 (first peak of the epidemic).\n\nThe study population consisted of 57,204,501 individuals living in Italy as of January 1, 2020. The number of excess deaths was 36,445, which accounts for 13.4% of excess mortalities from all causes during January-May 2020 (i.e., RH = 1.134; 95% confidence interval (CI): 1.129-1.140). In the macro-area with a relatively higher spread of COVID-19 (i.e., incidence rate, IR): 450-1,610 cases per 100,000 residents), the RH of excess deaths was 1.375 (95% CI: 1.364-1.386). In the area with a relatively moderate spread of COVID-19 (i.e., IR: 150-449 cases) it was 1.049 (95% CI: 1.038-1.060). In the area with a relatively lower spread of COVID-19 (i.e., IR: 30-149 cases), it was 0.967 (95% CI: 0.959-0.976). Between March and April (peak months of the first wave of the epidemic in Italy), we estimated an excess mortality from all causes of 43.5%. The RH of all-cause mortality for increments of 500 cases per 100,000 residents was 1.352 (95% CI: 1.346-1.359), corresponding to an increase of about 35%.\n\nOur analysis, making use of a population-based cohort model, estimated all-cause excess mortality in Italy taking account of both time period and of COVID-19 geographical spread. The study highlights the importance of a temporal/geographic framework in analyzing the risk of COVID-19-epidemy related mortality.", "doi": "10.4415/ANN_22_01_04", "pmid": "35324471", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Public Health": null, "Topics: Register-based research": null}, "xrefs": [], "notes": [], "created": "2022-04-04T07:00:43.085Z", "modified": "2022-04-04T07:00:52.509Z"}, {"entity": "publication", "iuid": "320c5e17ea1c4b2b94be7e555e8da3cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/320c5e17ea1c4b2b94be7e555e8da3cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/320c5e17ea1c4b2b94be7e555e8da3cb"}}, "title": "Selection analysis identifies clusters of unusual mutational changes in Omicron lineage BA.1 that likely impact Spike function.", "authors": [{"family": "Martin", "given": "Darren P", "initials": "DP", "orcid": "0000-0002-8785-0870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b43d72fdd57b4f908104e6f3056802ea.json"}}, {"family": "Lytras", "given": "Spyros", "initials": "S", "orcid": "0000-0003-4202-6682", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f440b2fe14e341bd829279d08a4a1de8.json"}}, {"family": "Lucaci", "given": "Alexander G", "initials": "AG"}, {"family": "Maier", "given": "Wolfgang", "initials": "W"}, {"family": "Gr\u00fcning", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Shank", "given": "Stephen D", "initials": "SD"}, {"family": "Weaver", "given": "Steven", "initials": "S"}, {"family": "MacLean", "given": "Oscar A", "initials": "OA", "orcid": "0000-0003-4919-4697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7169fd6ed48a4d10a0851eb90d2fb601.json"}}, {"family": "Orton", "given": "Richard J", "initials": "RJ", "orcid": "0000-0002-3389-4325", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7dae63399f52461ab68cefc6e6bc95d6.json"}}, {"family": "Lemey", "given": "Philippe", "initials": "P"}, {"family": "Boni", "given": "Maciej F", "initials": "MF"}, {"family": "Tegally", "given": "Houriiyah", "initials": "H"}, {"family": "Harkins", "given": "Gordon W", "initials": "GW"}, {"family": "Scheepers", "given": "Cathrine", "initials": "C"}, {"family": "Bhiman", "given": "Jinal N", "initials": "JN"}, {"family": "Everatt", "given": "Josie", "initials": "J"}, {"family": "Amoako", "given": "Daniel G", "initials": "DG"}, {"family": "San", "given": "James Emmanuel", "initials": "JE"}, {"family": "Giandhari", "given": "Jennifer", "initials": "J"}, {"family": "Sigal", "given": "Alex", "initials": "A", "orcid": "0000-0001-8571-2004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/197afb3112db40bd8d11247fa817b44f.json"}}, {"family": "NGS-SA", "given": "", "initials": ""}, {"family": "Williamson", "given": "Carolyn", "initials": "C"}, {"family": "Hsiao", "given": "Nei-Yuan", "initials": "NY"}, {"family": "von Gottberg", "given": "Anne", "initials": "A"}, {"family": "De Klerk", "given": "Arne", "initials": "A"}, {"family": "Shafer", "given": "Robert W", "initials": "RW"}, {"family": "Robertson", "given": "David L", "initials": "DL", "orcid": "0000-0001-6338-0221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7032efbe870440ccba1ebeed797be7b1.json"}}, {"family": "Wilkinson", "given": "Robert J", "initials": "RJ"}, {"family": "Sewell", "given": "B Trevor", "initials": "BT"}, {"family": "Lessells", "given": "Richard", "initials": "R"}, {"family": "Nekrutenko", "given": "Anton", "initials": "A", "orcid": "0000-0002-5987-8032", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e604351c6b64d15926f3392cd87ab87.json"}}, {"family": "Greaney", "given": "Allison J", "initials": "AJ"}, {"family": "Starr", "given": "Tyler N", "initials": "TN"}, {"family": "Bloom", "given": "Jesse D", "initials": "JD", "orcid": "0000-0003-1267-3408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f86f4a7b94e41358a4770ac2aa9b1b4.json"}}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Wilkinson", "given": "Eduan", "initials": "E"}, {"family": "Gupta", "given": "Ravindra K", "initials": "RK", "orcid": "0000-0001-9751-1808", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5fe96ec97d14f06a421cd22417544c9.json"}}, {"family": "de Oliveira", "given": "Tulio", "initials": "T", "orcid": "0000-0002-3027-5254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3dadcb78141a496ba76769d69667bf79.json"}}, {"family": "Kosakovsky Pond", "given": "Sergei L", "initials": "SL", "orcid": "0000-0003-4817-4029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59b8eb4236b3414291e4a0a5f81d5746.json"}}], "type": "journal article", "published": "2022-03-24", "journal": {"title": "Mol Biol Evol", "issn": "1537-1719", "issn-l": null}, "abstract": "Among the 30 non-synonymous nucleotide substitutions in the Omicron S-gene are 13 that have only rarely been seen in other SARS-CoV-2 sequences. These mutations cluster within three functionally important regions of the S-gene at sites that will likely impact (i) interactions between subunits of the Spike trimer and the predisposition of subunits to shift from down to up configurations, (ii) interactions of Spike with ACE2 receptors, and (iii) the priming of Spike for membrane fusion. We show here that, based on both the rarity of these 13 mutations in intrapatient sequencing reads and patterns of selection at the codon sites where the mutations occur in SARS-CoV-2 and related sarbecoviruses, prior to the emergence of Omicron the mutations would have been predicted to decrease the fitness of any virus within which they occurred. We further propose that the mutations in each of the three clusters therefore cooperatively interact to both mitigate their individual fitness costs, and, in combination with other mutations, adaptively alter the function of Spike. Given the evident epidemic growth advantages of Omicron over all previously known SARS-CoV-2 lineages, it is crucial to determine both how such complex and highly adaptive mutation constellations were assembled within the Omicron S-gene, and why, despite unprecedented global genomic surveillance efforts, the early stages of this assembly process went completely undetected.", "doi": "10.1093/molbev/msac061", "pmid": "35325204", "labels": {"Category: Health": null, "Category: Omicron VoC": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6553617"}], "notes": [], "created": "2022-04-04T07:00:24.978Z", "modified": "2022-04-04T07:00:25.380Z"}, {"entity": "publication", "iuid": "c9e79fd52e204fd7879a3be9141be7f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9e79fd52e204fd7879a3be9141be7f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9e79fd52e204fd7879a3be9141be7f7"}}, "title": "Role of Newly Introduced Teledentistry Service in the Management of Dental Emergencies During COVID-19 Pandemic in Qatar: A Cross-Sectional Analysis.", "authors": [{"family": "Ali", "given": "Shaymaa Abdulreda", "initials": "SA", "orcid": "0000-0003-3420-7096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5288ffb0fc4845fd82d93e3858762284.json"}}, {"family": "Al-Qahtani", "given": "Abdul Mueen A", "initials": "AMA"}, {"family": "Al Banai", "given": "Suhayla R", "initials": "SR"}, {"family": "Albaker", "given": "Fatima J", "initials": "FJ"}, {"family": "Almarri", "given": "Alanoud E", "initials": "AE"}, {"family": "Al-Haithami", "given": "Khalid", "initials": "K"}, {"family": "Khandakji", "given": "Mohannad N", "initials": "MN"}, {"family": "El Ansari", "given": "Walid", "initials": "W"}], "type": "journal article", "published": "2022-03-24", "journal": {"title": "Telemed J E Health", "issn": "1556-3669", "issn-l": null}, "abstract": "Introduction:The lockdown imposed by the COVID-19 pandemic rendered teledentistry (TD) necessary to maintain the continuity of oral health services and avoid missing emergency dental conditions, while minimizing face-to-face visits. Our objective was to evaluate the ability of a newly introduced triage-based TD service to deliver its goals, by evaluating its processes and outcomes and assessing the demand for TD. Methods:This cross-sectional report assessed the triage processes and outcomes (triage category, referral to emergency/dental facility undertaken, remote medications prescribed, and procedures performed at the point of referral); and evaluated the demand for the newly introduced TD service during 5 months of the first wave of the pandemic. Results:Of 850 calls, about 70.6% of the samples were managed remotely; 29.4% were categorized as emergency/urgent and referred to the emergency/dental facility. Compared with other complaints, orofacial dental pain was the most common reason for the calls (41.6%, p < 0.0001). About 14.71% of callers received prescription for medications remotely. The most demanded disciplines were general dentistry, orthodontics, and oral surgery, respectively (p < 0.0001). Of those referred to a dental facility, 31.84% required no clinical intervention, 28.7% received orthodontic appliance repair, and 14.3% and 11.2% had urgent dental extractions or root canal treatments. Demand on the service fluctuated through various distinct stages of the lockdown. Conclusions:There has been continuous demand for the newly introduced TD service throughout the period of the current report despite the fluctuations, with most complaints managed remotely. TD was effective and suitable for triage, service delivery, and care during the pandemic.", "doi": "10.1089/tmj.2021.0584", "pmid": "35333637", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2022-04-04T06:57:08.271Z", "modified": "2022-04-04T06:57:08.335Z"}, {"entity": "publication", "iuid": "33c17f7d64144bcbbedd0979d29ac155", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/33c17f7d64144bcbbedd0979d29ac155.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/33c17f7d64144bcbbedd0979d29ac155"}}, "title": "Interpreter-mediated interactions between people using a signed respective spoken language across distances in real time: a scoping review.", "authors": [{"family": "Warnicke", "given": "Camilla", "initials": "C"}, {"family": "Granberg", "given": "Sarah", "initials": "S"}], "type": "journal article", "published": "2022-03-24", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "volume": "22", "issue": "1", "pages": "387", "issn-l": null}, "abstract": "Communication between people who are deaf and sign and people who use a spoken language is possible by means of an interpreter. Interpreting in real time can be performed at a distance, which differs from interpreting face-to-face. Due to COVID-19, interpretation at a distance has increased.\n\nThe objective of this study was to map the existing literature to identify key characteristics by addressing the following question: What is known about interpreted mediated interactions between people using a signed respective spoken language across distances in real time?\n\nEight online databases, complemented by a search in one nonindexed journal of relevance to the review, were used to identify original studies published in 2010-2020, and 17 publications met the inclusion criteria. Charting of the data revealed insight from 17 original studies that were extracted, summarized, and reported.\n\nFour key characteristics were identified: (1) advantages and challenges in remote interpreting; (2) the need for training in remote interpreting and video relay service (VRS); (3) regulations and organizational structures of VRS; and (4) the interpreter as an active party in VRS.\n\nRemote interpreting has several challenges but also advantages. Knowledge of these kinds of interactions is limited, and further research must be initiated and realized, not least due to technological developments and the increased number of interpreting events.", "doi": "10.1186/s12913-022-07776-y", "pmid": "35331227", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-022-07776-y"}, {"db": "pmc", "key": "PMC8943107"}], "notes": [], "created": "2022-04-04T06:59:02.674Z", "modified": "2022-04-04T06:59:02.688Z"}, {"entity": "publication", "iuid": "690ccbdf2df14e38bbf07914827a68f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/690ccbdf2df14e38bbf07914827a68f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/690ccbdf2df14e38bbf07914827a68f1"}}, "title": "Association of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes.", "authors": [{"family": "Magnus", "given": "Maria C", "initials": "MC"}, {"family": "\u00d6rtqvist", "given": "Anne K", "initials": "AK"}, {"family": "Dahlqwist", "given": "Elisabeth", "initials": "E"}, {"family": "Ljung", "given": "Rickard", "initials": "R"}, {"family": "Sk\u00e5r", "given": "Fredrik", "initials": "F"}, {"family": "Oakley", "given": "Laura", "initials": "L"}, {"family": "Macsali", "given": "Ferenc", "initials": "F"}, {"family": "Pasternak", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Gjessing", "given": "H\u00e5kon K", "initials": "HK"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}], "type": "journal article", "published": "2022-03-24", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484", "volume": null, "issue": null, "pages": null}, "abstract": "Data about the safety of vaccines against SARS-CoV-2 during pregnancy are limited.\r\n\r\nTo examine the risk of adverse pregnancy outcomes after vaccination against SARS-CoV-2 during pregnancy.\r\n\r\nThis registry-based retrospective cohort study included 157 521 singleton pregnancies ending after 22 gestational weeks from January 1, 2021, until January 12, 2022 (Sweden), or January 15, 2022 (Norway). The Pregnancy Register in Sweden and the Medical Birth Registry of Norway were linked to vaccination and other registries for identification of exposure and background characteristics.\r\n\r\nData on mRNA vaccines-BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna)-and 1 viral vector vaccine-AZD1222 (AstraZeneca)-were collected from national vaccination registries.\r\n\r\nThe risk of preterm birth and stillbirth was evaluated using Cox regression models, with gestational day as the time metric and vaccination as a time-dependent exposure variable. The risk of small for gestational age, low Apgar score, and neonatal care admission was evaluated using logistic regression. Random-effects meta-analysis was used to combine results between countries.\r\n\r\nAmong the 157 521 singleton births included in the study (103 409 in Sweden and 54 112 in Norway), the mean maternal age at the time of delivery was 31 years, and 28 506 (18%) were vaccinated against SARS-CoV-2 (12.9% with BNT162b2, 4.8% with mRNA-1273, and 0.3% with AZD1222) while pregnant. A total of 0.7%, 8.3%, and 9.1% of individuals delivering were vaccinated during the first, second, and third trimester, respectively. Vaccination against SARS-CoV-2 was not significantly associated with increased risk of preterm birth (6.2 vs 4.9 per 10 000 pregnancy days; adjusted hazard ratio [aHR], 0.98 [95% CI, 0.91 to 1.05]; I2 = 0%; P for heterogeneity = .60), stillbirth (2.1 vs 2.4 per 100 000 pregnancy days; aHR, 0.86 [95% CI, 0.63 to 1.17]), small for gestational age (7.8% vs 8.5%; difference, -0.6% [95% CI, -1.3% to 0.2%]; adjusted OR [aOR], 0.97 [95% CI, 0.90 to 1.04]), low Apgar score (1.5% vs 1.6%; difference, -0.05% [95% CI, -0.3% to 0.1%]; aOR, 0.97 [95% CI, 0.87 to 1.08]), or neonatal care admission (8.5% vs 8.5%; difference, 0.003% [95% CI, -0.9% to 0.9%]; aOR, 0.97 [95% CI, 0.86 to 1.10]).\r\n\r\nIn this population-based study conducted in Sweden and Norway, vaccination against SARS-CoV-2 during pregnancy, compared with no SARS-CoV-2 vaccination during pregnancy, was not significantly associated with an increased risk of adverse pregnancy outcomes. The majority of the vaccinations were with mRNA vaccines during the second and third trimesters of pregnancy, which should be considered in interpreting the findings.", "doi": "10.1001/jama.2022.3271", "pmid": "35323851", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2790608"}], "notes": [], "created": "2022-04-04T07:01:07.549Z", "modified": "2022-04-04T07:01:45.109Z"}, {"entity": "publication", "iuid": "2c847a155f2541e8ab624cfe169d8464", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c847a155f2541e8ab624cfe169d8464.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c847a155f2541e8ab624cfe169d8464"}}, "title": "The cannabinoid receptor-1 gene interacts with stressful life events to increase the risk for problematic alcohol use.", "authors": [{"family": "Bornscheuer", "given": "Lisa", "initials": "L"}, {"family": "Lundin", "given": "Andreas", "initials": "A"}, {"family": "Forsell", "given": "Yvonne", "initials": "Y"}, {"family": "Lavebratt", "given": "Catharina", "initials": "C"}, {"family": "Melas", "given": "Philippe A", "initials": "PA"}], "type": "journal article", "published": "2022-03-23", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "4963", "issn-l": "2045-2322"}, "abstract": "Problematic alcohol use is a major contributor to the global burden of death and disabilities, and it represents a public health concern that has grown substantially following the COVID-19 pandemic. The available treatment options remain limited and to develop better pharmacotherapies for alcohol misuse we need to identify suitable biological targets. Previous research has implicated the brain's endocannabinoid system (ECS) in psychiatric and stress-related outcomes, including substance use and habituation to repeated stress. Moreover, genetic variants in the cannabinoid-1 receptor gene (CNR1; CB1R) have been associated with personality traits, which are in turn predictors of substance use disorders. To date, however, no human genome-wide association study has provided evidence for an involvement of the ECS in substance use outcomes. One reason for this ECS-related \"missing heritability\" may be unexamined gene-environment interactions. To explore this possibility, we conducted cross-sectional analyses using DNA samples and stress-exposure data from a longitudinal Swedish population-based study (N = 2,915). Specifically, we genotyped rs2023239, a functional C/T single nucleotide polymorphism in CNR1, previously reported to be associated with CNR1 binding in the brain, subjective reward following alcohol intake, and alcohol cue-elicited brain activation. Our two outcomes of interest were (i) problematic alcohol use based on the Alcohol Use Disorders Identification Test (AUDIT), and (ii) personality trait scores based on the Five Factor Model. We found no baseline association between rs2023239 and problematic alcohol use or personality traits. However, there was a clear trend for interaction between rs2023239's risk allele (C) and stressful life events (SLEs) in both childhood and adulthood, which predicted problematic alcohol use. Although not significant, there was also some indication that the risk allele interacted with child SLEs to increase scores on neuroticism. Our study supports the notion that the ECS can affect alcohol intake behaviors by interacting with life adversities and is-to the best of our knowledge-the first to focus on the interaction between CNR1 and stressors in both childhood and adulthood in humans. Further studies are warranted to confirm these findings.", "doi": "10.1038/s41598-022-08980-w", "pmid": "35322131", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-08980-w"}, {"db": "pmc", "key": "PMC8941304"}], "notes": [], "created": "2022-04-04T07:01:57.049Z", "modified": "2022-04-04T07:01:57.064Z"}, {"entity": "publication", "iuid": "036b84ea926f49ef991e707003c87736", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/036b84ea926f49ef991e707003c87736.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/036b84ea926f49ef991e707003c87736"}}, "title": "Pandemic trends in health care use: From the hospital bed to self-care with COVID-19.", "authors": [{"family": "Methi", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-7091-0806", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb34bc6f3c664b55b2240d9de0114cd4.json"}}, {"family": "Hern\u00e6s", "given": "Kjersti Helene", "initials": "KH"}, {"family": "Skyrud", "given": "Katrine Damgaard", "initials": "KD"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2022-03-23", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "3", "pages": "e0265812", "issn-l": "1932-6203"}, "abstract": "To explore whether the acute 30-day burden of COVID-19 on health care use has changed from February 2020 to February 2022.\n\nIn all Norwegians (N = 493 520) who tested positive for SARS-CoV-2 in four pandemic waves (February 26th, 2020 -February 16th, 2021 (1st wave dominated by the Wuhan strain), February 17th-July 10th, 2021 (2nd wave dominated by the Alpha variant), July 11th-December 27th, 2021 (3rd wave dominated by the Delta variant), and December 28th, 2021 -January 14th, 2022 (4th wave dominated by the Omicron variant)), we studied the age- and sex-specific share of patients (by age groups 1-19, 20-67, and 68 or more) who had: 1) Relied on self-care, 2) used outpatient care (visiting general practitioners or emergency ward for COVID-19), and 3) used inpatient care (hospitalized \u226524 hours with COVID-19).\n\nWe find a remarkable decline in the use of health care services among COVID-19 patients for all age/sex groups throughout the pandemic. From 83% [95%CI = 83%-84%] visiting outpatient care in the first wave, to 80% [81%-81%], 69% [69%-69%], and 59% [59%-59%] in the second, third, and fourth wave. Similarly, from 4.9% [95%CI = 4.7%-5.0%] visiting inpatient care in the first wave, to 3.6% [3.4%-3.7%], 1.4% [1.3%-1.4%], and 0.5% [0.4%-0.5%]. Of persons testing positive for SARS-CoV-2, 41% [41%-41%] relied on self-care in the 30 days after testing positive in the fourth wave, compared to 16% [15%-16%] in the first wave.\n\nFrom 2020 to 2022, the use of COVID-19 related outpatient care services decreased with 29%, whereas the use of COVID-19 related inpatient care services decreased with 80%.", "doi": "10.1371/journal.pone.0265812", "pmid": "35320323", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-37160"}, {"db": "pmc", "key": "PMC8942224"}], "notes": [], "created": "2022-04-04T07:02:11.806Z", "modified": "2022-04-04T07:02:11.847Z"}, {"entity": "publication", "iuid": "09c87432b4ec47b5b2ebbf1a8bad41b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/09c87432b4ec47b5b2ebbf1a8bad41b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/09c87432b4ec47b5b2ebbf1a8bad41b0"}}, "title": "Lead time of early warning by wastewater surveillance for COVID-19: geographical variations and impacting factors.", "authors": [{"family": "Kumar", "given": "Manish", "initials": "M"}, {"family": "Jiang", "given": "Guangming", "initials": "G"}, {"family": "Kumar Thakur", "given": "Alok", "initials": "A"}, {"family": "Chatterjee", "given": "Shreya", "initials": "S"}, {"family": "Bhattacharya", "given": "Tanushree", "initials": "T"}, {"family": "Mohapatra", "given": "Sanjeeb", "initials": "S"}, {"family": "Chaminda", "given": "Tushara", "initials": "T"}, {"family": "Kumar Tyagi", "given": "Vinay", "initials": "V"}, {"family": "Vithanage", "given": "Meththika", "initials": "M"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Nghiem", "given": "Long D", "initials": "LD"}, {"family": "Sarkar", "given": "Dibyendu", "initials": "D"}, {"family": "Sonne", "given": "Christian", "initials": "C"}, {"family": "Mahlknecht", "given": "J\u00fcrgen", "initials": "J"}], "type": "journal article", "published": "2022-03-23", "journal": {"title": "Chem Eng J", "issn": "1385-8947", "pages": "135936", "issn-l": null}, "abstract": "The global data on the temporal tracking of the COVID-19 through wastewater surveillance needs to be comparatively evaluated to generate a proper and precise understanding of the robustness, advantages, and sensitivity of the wastewater-based epidemiological (WBE) approach. We reviewed the current state of knowledge based on forty scientific articles pertaining to temporal variations in COVID-19 cases captured via viral RNA predictions in wastewater. This paper primarily focuses on analyzing the WBE-based temporal variation reported globally to check if the reported early warning lead-time generated through environmental surveillance is pragmatic or latent. We have compiled the geographical variations reported as lead time in various WBE reports to strike a precise correlation between COVID-19 cases and genome copies detected through wastewater surveillance, with respect to the sampling dates, separately for WASH and non-WASH countries. We highlighted sampling methods, climatic and weather conditions that significantly affected the concentration of viral SARS-CoV-2 RNA detected in wastewater, and thus the lead time reported from the various climatic zones with diverse WASH situations were different. Our major findings are: i) WBE reports around the world are not comparable, especially in terms of gene copies detected, lag-time gained between monitored RNA peak and outbreak/peak of reported case, as well as per capita RNA concentrations; ii) Varying sanitation facility and climatic conditions that impact virus degradation rate are two major interfering features limit the comparability of WBE results, and iii) WBE is better applicable to WASH countries having well-connected sewerage system.", "doi": "10.1016/j.cej.2022.135936", "pmid": "35345777", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1385-8947(22)01434-6"}, {"db": "pmc", "key": "PMC8942437"}], "notes": [], "created": "2022-04-04T06:48:56.332Z", "modified": "2022-04-04T06:48:56.349Z"}, {"entity": "publication", "iuid": "79ff04a2f9d54e14b1d6461044ebd251", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79ff04a2f9d54e14b1d6461044ebd251.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79ff04a2f9d54e14b1d6461044ebd251"}}, "title": "Interactions between glucosides of the tip of the S1 subunit of SARS-CoV-2 spike protein and dry and wet surfaces of CuO and Cu-A model for the surfaces of coinage metals.", "authors": [{"family": "Lousada", "given": "Cl\u00e1udio M", "initials": "CM"}], "type": "journal article", "published": "2022-03-23", "journal": {"title": "Colloids Surf B Biointerfaces", "issn": "1873-4367", "volume": "214", "pages": "112465", "issn-l": null}, "abstract": "Despite their importance there is little knowledge at the atomic scale on the interactions between fragments of SARS-CoV-2 and inorganic materials. Such knowledge is important to understand the survival of the virus at surfaces and for the development of antiviral materials. Here is reported a study of the interactions between glucoside monomers of the tip of the S1 subunit of SARS-CoV-2 spike protein with dry and wet surfaces of CuO and Cu, performed with dispersion corrected density functional theory-DFT. The three glucoside monomers that constitute the tip of S1: 6VSB, 6VXX and 6X6P, were adsorbed onto dry and wet CuO(111) and Cu(110) with different orientations and surface alignments. There are large differences-of up to 1.3 eV-in binding energies between these monomers and the surfaces. These differences depend on: the type of surface; if the surface is wet or dry; if the glucosidic O-atom points towards or away from the surfaces; and to a smaller extent on the surface alignment of the monomers. All monomers bind strongly to the surfaces via molecular adsorption that does not involve bond breaking in the monomers at this stage. 6VSB has the larger adsorption energies-that reach 2.2 eV-due to its larger dipole moment. Both materials bind the monomers more strongly when their surfaces are dry. At Cu(110) the bonds are on average 1 eV stronger when the surface is dry when compared to wet. The difference between dry and wet CuO(111) is smaller, in the order of 0.2 eV. Overall, it is here shown that the stability of the monomers of the tip of the spike protein of the virus is very different at different surfaces. For a given surface the larger binding energies in dry conditions could explain the differences in the surface stability of the spike protein depending on the presence of moisture.", "doi": "10.1016/j.colsurfb.2022.112465", "pmid": "35334309", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0927-7765(22)00148-5"}, {"db": "pmc", "key": "PMC8940556"}], "notes": [], "created": "2022-04-04T06:56:25.566Z", "modified": "2022-04-04T06:56:25.600Z"}, {"entity": "publication", "iuid": "645d7465d1d240e586809755a25e4438", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/645d7465d1d240e586809755a25e4438.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/645d7465d1d240e586809755a25e4438"}}, "title": "Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19.", "authors": [{"family": "Abraham", "given": "George R", "initials": "GR"}, {"family": "Kuc", "given": "Rhoda E", "initials": "RE"}, {"family": "Althage", "given": "Magnus", "initials": "M"}, {"family": "Greasley", "given": "Peter J", "initials": "PJ"}, {"family": "Ambery", "given": "Philip", "initials": "P"}, {"family": "Maguire", "given": "Janet J", "initials": "JJ"}, {"family": "Wilkinson", "given": "Ian B", "initials": "IB"}, {"family": "Hoole", "given": "Stephen P", "initials": "SP"}, {"family": "Cheriyan", "given": "Joseph", "initials": "J"}, {"family": "Davenport", "given": "Anthony P", "initials": "AP"}], "type": "journal article", "published": "2022-03-23", "journal": {"title": "J Mol Cell Cardiol", "issn": "1095-8584", "issn-l": null}, "abstract": "Virus induced endothelial dysregulation is a well-recognised feature of severe Covid-19 infection. Endothelin-1 (ET-1) is the most highly expressed peptide in endothelial cells and a potent vasoconstrictor, thus representing a potential therapeutic target. ET-1 plasma levels were measured in a cohort of 194 Covid-19 patients stratified according to the clinical severity of their illness. Hospitalised patients, including those who died and those developing acute myocardial or kidney injury, had significantly elevated ET-1 plasma levels during the acute phase of infection. The results support the hypothesis that endothelin receptor antagonists may provide clinical benefit for certain Covid-19 patients.", "doi": "10.1016/j.yjmcc.2022.03.007", "pmid": "35339512", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S0022-2828(22)00051-7"}, {"db": "pmc", "key": "PMC8941861"}], "notes": [], "created": "2022-04-04T06:50:16.165Z", "modified": "2022-04-04T06:50:22.716Z"}, {"entity": "publication", "iuid": "9f671df3137144f6a38f39a6187293ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f671df3137144f6a38f39a6187293ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f671df3137144f6a38f39a6187293ee"}}, "title": "Unraveling COVID-19: A Large-Scale Characterization of 4.5 Million COVID-19 Cases Using CHARYBDIS.", "authors": [{"family": "Kostka", "given": "Kristin", "initials": "K", "orcid": "0000-0003-2595-8736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9675cf1b775341f6a3521c7dde950262.json"}}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T", "orcid": "0000-0002-8274-0357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11fd8deb257445e7a93a0a3098b246df.json"}}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A", "orcid": "0000-0003-1202-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47f086bb6ccd49a2a5f11a32c06277c8.json"}}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Pistillo", "given": "Andrea", "initials": "A", "orcid": "0000-0002-4467-0220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/055156368b8845a0bfdc522a53cc1b0d.json"}}, {"family": "Khalid", "given": "Sara", "initials": "S"}, {"family": "Lai", "given": "Lana Y H", "initials": "LYH"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM", "orcid": "0000-0002-5630-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5162aab03bc04dafa809108461f18667.json"}}, {"family": "Dawoud", "given": "Dalia M", "initials": "DM"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Wilcox", "given": "Adam B", "initials": "AB"}, {"family": "Andryc", "given": "Alan", "initials": "A", "orcid": "0000-0002-2663-2298", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9643da291a2b4aee87e4406e36cf6d16.json"}}, {"family": "Williams", "given": "Andrew", "initials": "A"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Jung", "given": "Chi Young", "initials": "CY"}, {"family": "Harle", "given": "Christopher A", "initials": "CA"}, {"family": "Reich", "given": "Christian G", "initials": "CG", "orcid": "0000-0002-3641-055X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6982fa4f228643c6bac91609a0b336d3.json"}}, {"family": "Blacketer", "given": "Clair", "initials": "C"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Dorr", "given": "David A", "initials": "DA"}, {"family": "Burn", "given": "Edward", "initials": "E", "orcid": "0000-0002-9286-1128", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cbd60c98f85a4067aec58f7b7819800c.json"}}, {"family": "Roel", "given": "Elena", "initials": "E"}, {"family": "Tan", "given": "Eng Hooi", "initials": "EH"}, {"family": "Minty", "given": "Evan", "initials": "E"}, {"family": "DeFalco", "given": "Frank", "initials": "F"}, {"family": "de Maeztu", "given": "Gabriel", "initials": "G"}, {"family": "Lipori", "given": "Gigi", "initials": "G"}, {"family": "Alghoul", "given": "Hiba", "initials": "H", "orcid": "0000-0001-8234-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e3deb1abdf54088a29dee7675a18697.json"}}, {"family": "Zhu", "given": "Hong", "initials": "H"}, {"family": "Thomas", "given": "Jason A", "initials": "JA"}, {"family": "Bian", "given": "Jiang", "initials": "J"}, {"family": "Park", "given": "Jimyung", "initials": "J", "orcid": "0000-0002-6998-2546", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa24df935da248cc94db2e63b09a3113.json"}}, {"family": "Mart\u00ednez Rold\u00e1n", "given": "Jordi", "initials": "J"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Banda", "given": "Juan M", "initials": "JM", "orcid": "0000-0001-8499-824X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab57c692026c41f4a50b7dd737594725.json"}}, {"family": "Horcajada", "given": "Juan P", "initials": "JP", "orcid": "0000-0001-9873-5459", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b302a6caec0949c6a652ab115ae8658f.json"}}, {"family": "Kohler", "given": "Julianna", "initials": "J"}, {"family": "Shah", "given": "Karishma", "initials": "K"}, {"family": "Natarajan", "given": "Karthik", "initials": "K", "orcid": "0000-0002-9066-9431", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d68e1b4844f408991c3f79af134ca15.json"}}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Liu", "given": "Li", "initials": "L", "orcid": "0000-0002-5265-4159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/232e751324fa46f3baa9ad4c008d1b99.json"}}, {"family": "Schilling", "given": "Lisa M", "initials": "LM"}, {"family": "Recalde", "given": "Martina", "initials": "M"}, {"family": "Spotnitz", "given": "Matthew", "initials": "M"}, {"family": "Gong", "given": "Mengchun", "initials": "M"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Valveny", "given": "Neus", "initials": "N", "orcid": "0000-0003-1105-5018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b4965da861b4b41a6ed0cd38bce356a.json"}}, {"family": "Weiskopf", "given": "Nicole G", "initials": "NG"}, {"family": "Shah", "given": "Nigam", "initials": "N"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Casajust", "given": "Paula", "initials": "P", "orcid": "0000-0003-2733-5436", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8a3feb959bd461c8c4ad81fcd9dee8b.json"}}, {"family": "Park", "given": "Rae Woong", "initials": "RW"}, {"family": "Schuff", "given": "Robert", "initials": "R"}, {"family": "Seager", "given": "Sarah", "initials": "S"}, {"family": "DuVall", "given": "Scott L", "initials": "SL", "orcid": "0000-0002-4898-3865", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd524264c46548cf861123d43d57151a.json"}}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Song", "given": "Seokyoung", "initials": "S", "orcid": "0000-0002-5653-7005", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92e87edc601f49f8ad197e84d690ed36.json"}}, {"family": "Fern\u00e1ndez-Bertol\u00edn", "given": "Sergio", "initials": "S"}, {"family": "Fortin", "given": "Stephen", "initials": "S"}, {"family": "Magoc", "given": "Tanja", "initials": "T", "orcid": "0000-0001-8213-2266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c3bdfe4f6d9f4d0497d28d18a1baea2e.json"}}, {"family": "Falconer", "given": "Thomas", "initials": "T", "orcid": "0000-0001-6904-1394", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39f9b217653b4b3d8ad2b4ce30d1ca80.json"}}, {"family": "Subbian", "given": "Vignesh", "initials": "V"}, {"family": "Huser", "given": "Vojtech", "initials": "V"}, {"family": "Ahmed", "given": "Waheed-Ul-Rahman", "initials": "WU", "orcid": "0000-0003-0880-0355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27d074e0c92342d299e693d12173356c.json"}}, {"family": "Carter", "given": "William", "initials": "W", "orcid": "0000-0001-5346-3453", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8dcef685912942dca4ed5e04c68c4f9c.json"}}, {"family": "Guan", "given": "Yin", "initials": "Y"}, {"family": "Galvan", "given": "Yankuic", "initials": "Y"}, {"family": "He", "given": "Xing", "initials": "X"}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Ryan", "given": "Patrick B", "initials": "PB"}, {"family": "Suchard", "given": "Marc A", "initials": "MA", "orcid": "0000-0001-9818-479X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f920e0e55c94e91b4dcff796bd24246.json"}}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D", "orcid": "0000-0002-3950-6346", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1c3f99e11244a3b90ba881356d3e259.json"}}], "type": "journal article", "published": "2022-03-22", "journal": {"title": "CLEP", "issn": "1179-1349", "volume": "14", "pages": "369-384", "issn-l": null}, "abstract": "Routinely collected real world data (RWD) have great utility in aiding the novel coronavirus disease (COVID-19) pandemic response. Here we present the international Observational Health Data Sciences and Informatics (OHDSI) Characterizing Health Associated Risks and Your Baseline Disease In SARS-COV-2 (CHARYBDIS) framework for standardisation and analysis of COVID-19 RWD.\n\nWe conducted a descriptive retrospective database study using a federated network of data partners in the United States, Europe (the Netherlands, Spain, the UK, Germany, France and Italy) and Asia (South Korea and China). The study protocol and analytical package were released on 11th June 2020 and are iteratively updated via GitHub. We identified three non-mutually exclusive cohorts of 4,537,153 individuals with a clinical COVID-19 diagnosis or positive test, 886,193 hospitalized with COVID-19, and 113,627 hospitalized with COVID-19 requiring intensive services.\n\nWe aggregated over 22,000 unique characteristics describing patients with COVID-19. All comorbidities, symptoms, medications, and outcomes are described by cohort in aggregate counts and are readily available online. Globally, we observed similarities in the USA and Europe: more women diagnosed than men but more men hospitalized than women, most diagnosed cases between 25 and 60 years of age versus most hospitalized cases between 60 and 80 years of age. South Korea differed with more women than men hospitalized. Common comorbidities included type 2 diabetes, hypertension, chronic kidney disease and heart disease. Common presenting symptoms were dyspnea, cough and fever. Symptom data availability was more common in hospitalized cohorts than diagnosed.\n\nWe constructed a global, multi-centre view to describe trends in COVID-19 progression, management and evolution over time. By characterising baseline variability in patients and geography, our work provides critical context that may otherwise be misconstrued as data quality issues. This is important as we perform studies on adverse events of special interest in COVID-19 vaccine surveillance.", "doi": "10.2147/CLEP.S323292", "pmid": "35345821", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "323292"}, {"db": "pmc", "key": "PMC8957305"}], "notes": [], "created": "2022-04-04T06:48:36.538Z", "modified": "2022-04-04T06:48:37.014Z"}, {"entity": "publication", "iuid": "ca51b638da9740ca8c52978f961759b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ca51b638da9740ca8c52978f961759b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ca51b638da9740ca8c52978f961759b1"}}, "title": "Current Approaches to Vaccine Safety Using Observational Data: A Rationale for the EUMAEUS (Evaluating Use of Methods for Adverse Events Under Surveillance-for Vaccines) Study Design.", "authors": [{"family": "Lai", "given": "Lana Yh", "initials": "LY"}, {"family": "Arshad", "given": "Faaizah", "initials": "F"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "Li", "given": "Xintong", "initials": "X"}, {"family": "Dawoud", "given": "Dalia", "initials": "D"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Pratt", "given": "Nicole", "initials": "N"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Prieto-Alhambra", "given": "Dani", "initials": "D"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Schuemie", "given": "Martijn J", "initials": "MJ"}], "type": "journal article", "published": "2022-03-22", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "issn-l": "1663-9812", "volume": "13", "issue": null, "pages": "837632"}, "abstract": "Post-marketing vaccine safety surveillance aims to detect adverse events following immunization in a population. Whether certain methods of surveillance are more precise and unbiased in generating safety signals is unclear. Here, we synthesized information from existing literature to provide an overview of the strengths, weaknesses, and clinical applications of epidemiologic and analytical methods used in vaccine monitoring, focusing on cohort, case-control and self-controlled designs. These designs are proposed to be evaluated in the EUMAEUS (Evaluating Use of Methods for Adverse Event Under Surveillance-for vaccines) study because of their widespread use and potential utility. Over the past decades, there have been an increasing number of epidemiological study designs used for vaccine safety surveillance. While traditional cohort and case-control study designs remain widely used, newer, novel designs such as the self-controlled case series and self-controlled risk intervals have been developed. Each study design comes with its strengths and limitations, and the most appropriate study design will depend on availability of resources, access to records, number and distribution of cases, and availability of population coverage data. Several assumptions have to be made while using the various study designs, and while the goal is to mitigate any biases, violations of these assumptions are often still present to varying degrees. In our review, we discussed some of the potential biases (i.e., selection bias, misclassification bias and confounding bias), and ways to mitigate them. While the types of epidemiological study designs are well established, a comprehensive comparison of the analytical aspects (including method evaluation and performance metrics) of these study designs are relatively less well studied. We summarized the literature, reporting on two simulation studies, which compared the detection time, empirical power, error rate and risk estimate bias across the above-mentioned study designs. While these simulation studies provided insights on the analytic performance of each of the study designs, its applicability to real-world data remains unclear. To bridge that gap, we provided the rationale of the EUMAEUS study, with a brief description of the study design; and how the use of real-world multi-database networks can provide insights into better methods evaluation and vaccine safety surveillance.", "doi": "10.3389/fphar.2022.837632", "pmid": "35392566", "labels": {"Category: Vaccines": null, "Category: Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8980923"}, {"db": "pii", "key": "837632"}], "notes": [], "created": "2023-01-13T09:52:58.045Z", "modified": "2023-01-13T09:53:58.946Z"}, {"entity": "publication", "iuid": "c621ce38cce94a0bb966a7b453952c00", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c621ce38cce94a0bb966a7b453952c00.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c621ce38cce94a0bb966a7b453952c00"}}, "title": "BMI, sex and outcomes in hospitalised patients in western Sweden during the COVID-19 pandemic.", "authors": [{"family": "Lindgren", "given": "Martin", "initials": "M"}, {"family": "Toska", "given": "Triantafyllia", "initials": "T"}, {"family": "Alex", "given": "Christian", "initials": "C"}, {"family": "Lundberg", "given": "Christina E", "initials": "CE"}, {"family": "Cronie", "given": "Ottmar", "initials": "O"}, {"family": "Rosengren", "given": "Annika", "initials": "A"}, {"family": "Adiels", "given": "Martin", "initials": "M"}, {"family": "Sj\u00f6land", "given": "Helen", "initials": "H"}], "type": "journal article", "published": "2022-03-22", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "4918", "issn-l": "2045-2322"}, "abstract": "High body mass index (BMI) is associated with severe COVID-19 but findings regarding the need of intensive care (IC) and mortality are mixed. Using electronic health records, we identified all patients in western Sweden hospitalised with COVID-19 to evaluate 30-day mortality or assignment to IC. Adjusted logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for outcomes. Of totally 9761 patients, BMI was available in 7325 (75%), included in the study. There was a marked inverse association between BMI and age (underweight and normal weight patients were on average 78 and 75 years, whereas overweight and obese were 68 and 62 years). While older age, male sex and several comorbidities associated with higher mortality after multivariable adjustment, BMI did not. However, BMI \u2265 30 kg/m2 (OR 1.46, 95% CI 1.21-1.75) was associated with need of IC; this association was restricted to women (BMI \u2265 30; OR 1.96 (95% CI 1.41-2.73), and not significant in men; OR 1.22 (95% CI 0.97-1.54). In this comprehensive hospital population with COVID-19, BMI was not associated with 30-day mortality risk. Among the obese, women, but not men, had a higher risk of assignment to IC.", "doi": "10.1038/s41598-022-09027-w", "pmid": "35318438", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8939489"}, {"db": "pii", "key": "10.1038/s41598-022-09027-w"}], "notes": [], "created": "2022-04-04T07:10:13.488Z", "modified": "2023-01-13T13:51:25.566Z"}, {"entity": "publication", "iuid": "7bd80e6ae702469a84e47666eea3e837", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7bd80e6ae702469a84e47666eea3e837.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7bd80e6ae702469a84e47666eea3e837"}}, "title": "Psychological Health and Digital Social Participation of the Older Adults during the COVID-19 Pandemic in Blekinge, Sweden-An Exploratory Study.", "authors": [{"family": "Ghazi", "given": "Sarah Nauman", "initials": "SN", "orcid": "0000-0001-8114-8813", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/100ab0ff0c8d4d0cbd2c29e1e9639099.json"}}, {"family": "Anderberg", "given": "Peter", "initials": "P", "orcid": "0000-0001-9870-8477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b827b4a21b643908e4f069979dd948b.json"}}, {"family": "Berglund", "given": "Johan Sanmartin", "initials": "JS", "orcid": "0000-0003-4312-2246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ecd51160e1e412baa035f8e78150d6e.json"}}, {"family": "Berner", "given": "Jessica", "initials": "J", "orcid": "0000-0002-2848-2377", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d14099d99cf4840b3f27c24929ffcb1.json"}}, {"family": "Dallora", "given": "Ana Luiza", "initials": "AL", "orcid": "0000-0002-6752-017X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc6a17faba5a434ba9b6fc8cfbb6a1dc.json"}}], "type": "journal article", "published": "2022-03-21", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "6", "issn-l": null}, "abstract": "COVID-19 has affected the psychological health of older adults directly and indirectly through recommendations of social distancing and isolation. Using the internet or digital tools to participate in society, one might mitigate the effects of COVID-19 on psychological health. This study explores the social participation of older adults through internet use as a social platform during COVID-19 and its relationship with various psychological health aspects. In this study, we used the survey as a research method, and we collected data through telephonic interviews; and online and paper-based questionnaires. The results showed an association of digital social participation with age and feeling lack of company. Furthermore, in addition, to the increase in internet use in older adults in Sweden during COVID-19, we conclude that digital social participation is essential to maintain psychological health in older adults.", "doi": "10.3390/ijerph19063711", "pmid": "35329398", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8954168"}, {"db": "pii", "key": "ijerph19063711"}], "notes": [], "created": "2022-04-04T06:59:37.623Z", "modified": "2023-01-13T13:54:33.282Z"}, {"entity": "publication", "iuid": "0086246b36c84a929b363e65a2c76447", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0086246b36c84a929b363e65a2c76447.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0086246b36c84a929b363e65a2c76447"}}, "title": "No man is an island: management of the emergency response to the SARS-CoV-2 (COVID-19) outbreak in a large public decentralised service delivery organisation.", "authors": [{"family": "Ohrling", "given": "Mikael", "initials": "M"}, {"family": "Solberg Carlsson", "given": "Karin", "initials": "K"}, {"family": "Brommels", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2022-03-21", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "volume": "22", "issue": "1", "pages": "371", "issn-l": null}, "abstract": "We wanted to better understand whether and how agility can be achieved in a decentralised service delivery organisation in Sweden. The pandemic outbreak of SARS-Cov-2 (Covid-19) provided an opportunity to assess decentralisation as a strategy to improve the responsiveness of healthcare and at the same time handle an unpredictable and unexpected event.\n\nData from in-depth interviews with a crisis management team (n = 23) and free text answers in a weekly survey to subordinated clinical directors, i.e. unit managers, (n = 108) were scrutinised in a directed content analysis. Dynamic capabilities as a prerequisite for dynamic effectiveness, understood as reaching strategic and operative effectiveness simultaneously, were explored by using three frameworks for dynamic effectiveness, dynamic capabilities and delegated authority in a decentralised organisation.\n\nUnpredictable events, such as the pandemic Covid-19 outbreak, demand a high grade of ability to be flexible. We find that a high degree of operational effectiveness, which is imperative in an emergency situation, also is a driver of seeking new strategic positions to even better meet new demands. The characteristics of the dynamic capabilities evolving from this process are described and discussed in relation to decentralisation, defined by decision space, organisational and individual capacity as well as accountability. We present arguments supporting that a decentralised management model can facilitate the agility required in an emergency.\n\nThis study is, to our knowledge, the first of its kind where a decentralised management model in a service delivery organisation in healthcare is studied in relation to crisis management. Although stemming from one organisation, our findings indicating the value of decentralisation in situations of crisis are corroborated by theory, suggesting that they could be relevant in other organisational settings also.", "doi": "10.1186/s12913-022-07716-w", "pmid": "35313891", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-022-07716-w"}, {"db": "pmc", "key": "PMC8935606"}], "notes": [], "created": "2022-03-23T06:14:10.289Z", "modified": "2022-04-04T07:11:17.984Z"}, {"entity": "publication", "iuid": "fb52b1f6da5e4ee0881b3ae3dfb465f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb52b1f6da5e4ee0881b3ae3dfb465f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb52b1f6da5e4ee0881b3ae3dfb465f4"}}, "title": "Improved Binding Affinity of Omicron's Spike Protein for the Human Angiotensin-Converting Enzyme 2 Receptor Is the Key behind Its Increased Virulence.", "authors": [{"family": "Kumar", "given": "Rajender", "initials": "R"}, {"family": "Murugan", "given": "Natarajan Arul", "initials": "NA", "orcid": "0000-0003-0185-5724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/293acfd743f94993bd6aca57b01cd604.json"}}, {"family": "Srivastava", "given": "Vaibhav", "initials": "V", "orcid": "0000-0003-1877-4154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f6299b3ddf14b88866157ec4b4113b0.json"}}], "type": "journal article", "published": "2022-03-21", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "23", "issue": "6", "issn-l": null}, "abstract": "The new variant of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), Omicron, has been quickly spreading in many countries worldwide. Compared to the original virus, Omicron is characterized by several mutations in its genomic region, including the spike protein's receptor-binding domain (RBD). We have computationally investigated the interaction between the RBD of both the wild type and Omicron variant of SARS-CoV-2 with the human angiotensin-converting enzyme 2 (hACE2) receptor using molecular dynamics and molecular mechanics-generalized Born surface area (MM-GBSA)-based binding free energy calculations. The mode of the interaction between Omicron's RBD with the hACE2 receptor is similar to the original SARS-CoV-2 RBD except for a few key differences. The binding free energy difference shows that the spike protein of Omicron has an increased affinity for the hACE2 receptor. The mutated residues in the RBD showed strong interactions with a few amino acid residues of hACE2. More specifically, strong electrostatic interactions (salt bridges) and hydrogen bonding were observed between R493 and R498 residues of the Omicron RBD with D30/E35 and D38 residues of the hACE2, respectively. Other mutated amino acids in the Omicron RBD, e.g., S496 and H505, also exhibited hydrogen bonding with the hACE2 receptor. A pi-stacking interaction was also observed between tyrosine residues (RBD-Tyr501: hACE2-Tyr41) in the complex, which contributes majorly to the binding free energies and suggests that this is one of the key interactions stabilizing the formation of the complex. The resulting structural insights into the RBD:hACE2 complex, the binding mode information within it, and residue-wise contributions to the free energy provide insight into the increased transmissibility of Omicron and pave the way to design and optimize novel antiviral agents.", "doi": "10.3390/ijms23063409", "pmid": "35328828", "labels": {"Category: Health": null, "Category: Omicron VoC": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijms23063409"}, {"db": "pmc", "key": "PMC8955673"}], "notes": [], "created": "2022-04-04T06:59:54.410Z", "modified": "2022-04-04T06:59:54.512Z"}, {"entity": "publication", "iuid": "ecdade19e7e247f18497e4508d9ea7b6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ecdade19e7e247f18497e4508d9ea7b6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ecdade19e7e247f18497e4508d9ea7b6"}}, "title": "Fear of COVID-19 and its association with mental health-related factors: systematic review and meta-analysis.", "authors": [{"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Ohayon", "given": "Maurice M", "initials": "MM", "orcid": "0000-0002-2757-5440", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11af7871e5f948c0b730031f9b2fc03f.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2022-03-21", "journal": {"title": "BJPsych Open", "issn": "2056-4724", "volume": "8", "issue": "2", "pages": "e73", "issn-l": null}, "abstract": "The severity of COVID-19 remains high worldwide. Therefore, millions of individuals are likely to suffer from fear of COVID-19 and related mental health factors.\n\nThe present systematic review and meta-analysis aimed to synthesize empirical evidence to understand fear of COVID-19 and its associations with mental health-related problems during this pandemic period.\n\nRelevant studies were searched for on five databases (Scopus, ProQuest, EMBASE, PubMed Central, and ISI Web of Knowledge), using relevant terms (COVID-19-related fear, anxiety, depression, mental health-related factors, mental well-being and sleep problems). All studies were included for analyses irrespective of their methodological quality, and the impact of quality on pooled effect size was examined by subgroup analysis.\n\nThe meta-analysis pooled data from 91 studies comprising 88 320 participants (mean age 38.88 years; 60.66% females) from 36 countries. The pooled estimated mean of fear of COVID-19 was 13.11 (out of 35), using the Fear of COVID-19 Scale. The associations between fear of COVID-19 and mental health-related factors were mostly moderate (Fisher's z = 0.56 for mental health-related factors; 0.54 for anxiety; 0.42 for stress; 0.40 for depression; 0.29 for sleep problems and -0.24 for mental well-being). Methodological quality did not affect these associations.\n\nFear of COVID-19 has associations with various mental health-related factors. Therefore, programmes for reducing fear of COVID-19 and improving mental health are needed.", "doi": "10.1192/bjo.2022.26", "pmid": "35307051", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2056472422000266"}, {"db": "pmc", "key": "PMC8943231"}], "notes": [], "created": "2022-03-23T06:15:25.083Z", "modified": "2022-04-04T07:11:41.809Z"}, {"entity": "publication", "iuid": "2465b2a255c449c98dbe9eb9e8e85164", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2465b2a255c449c98dbe9eb9e8e85164.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2465b2a255c449c98dbe9eb9e8e85164"}}, "title": "The Swedish gamble: trust in the government and self-efficacy in the battle to combat COVID-19.", "authors": [{"family": "Hassan", "given": "Mohammed Salah", "initials": "MS", "orcid": "0000-0002-1742-2790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e712ec5774ec44d5a84da8da847ec9e9.json"}}, {"family": "Al Halbusi", "given": "Hussam", "initials": "H"}, {"family": "Razali", "given": "Asbah", "initials": "A"}, {"family": "Ariffin", "given": "Raja Noriza Raja", "initials": "RNR"}, {"family": "Williams", "given": "Kent A", "initials": "KA"}], "type": "journal article", "published": "2022-03-19", "journal": {"title": "Curr Psychol", "issn": "1046-1310", "pages": "1-16", "issn-l": null}, "abstract": "Governments around the world have issued movement restrictions and quarantines to combat the SARS-CoV-2 (COVID-19) pandemic. However, the Swedish government has not implemented such measures but has depended on individual responsibility. The extent to which individuals have been encouraged to trust in and be satisfied with government strategies and adopt personal health measures, such as social isolation, remains unclear. This study examines the direct effects of trust in the government and risk perception on self-efficacy. Most importantly, this study intends to explore whether satisfaction with government measures strengthens the relationships between 1) trust in the government and self-efficacy and 2) risk perception and self-efficacy. We test our suggested hypotheses using survey data obtained from 403 Swedish citizens living in Sweden. As predicted, the findings indicate that trust in the government and risk perception positively impact individual self-efficacy. Additionally, the findings reveal that satisfaction with government measures strengthens these relationships; more precisely, the impact of trust in the government and risk perception under a high level of individual satisfaction with government measures is much more positive than that under a low satisfaction level. In practice, a focus on implementing successful policies and excellent individual self-efficacy is required to halt the pandemic, and the findings indicate that combining strictly attentive and adaptive individual strategies with government strategies can minimize the spread of infection.", "doi": "10.1007/s12144-022-02947-w", "pmid": "35340688", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "2947"}, {"db": "pmc", "key": "PMC8933660"}], "notes": [], "created": "2022-04-04T06:49:57.235Z", "modified": "2022-04-04T06:49:57.294Z"}, {"entity": "publication", "iuid": "6221bb142023474cbb6069d730245cce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6221bb142023474cbb6069d730245cce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6221bb142023474cbb6069d730245cce"}}, "title": "Small business managers and Covid-19-The role of a sense of coherence and general resistance resources in coping with stressors.", "authors": [{"family": "Hansson", "given": "Josefine", "initials": "J", "orcid": "0000-0001-6385-1556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04f28c63354f4e11b27b8abdab4c58b7.json"}}, {"family": "Landstad", "given": "Bodil J", "initials": "BJ"}, {"family": "Vinberg", "given": "Stig", "initials": "S"}, {"family": "Hedlund", "given": "Marianne", "initials": "M", "orcid": "0000-0002-1789-2477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d8e2939573845109d470f05b8314cee.json"}}, {"family": "Tjulin", "given": "\u00c5sa", "initials": "\u00c5"}], "type": "journal article", "published": "2022-03-18", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "17", "issue": "3", "pages": "e0265029"}, "abstract": "The response of small business managers to an external event such as the pandemic can have a profound effect on the work environment, health and well-being for themselves and their employees. Previous research on small business managers during the pandemic has mainly focused on traditional pathogenic effects, and there is a lack of studies looking at the issue from a salutogenic health promotion perspective. The aim of this study is to explore whether a sense of coherence and general resistance resources were experienced by small business managers in Sweden and Norway during the Covid-19 pandemic.\r\n\r\nA qualitative design was applied through exploratory interviews with 16 managers of small businesses in Sweden and Norway. A content analysis of the interviews was conducted using the sense of coherence concept by Aaron Antonovsky, with the three main components of comprehensibility, meaningfulness and manageability acting as a conceptual framework for the analysis process.\r\n\r\nWithin the three main sense-of-coherence categories, six general resistance resources were identified as being important for the managers to handle uncertainty during the pandemic. These were understanding rules and regulations, social support, optimism, proactivity, problem-solving and flexibility and cooperation.\r\n\r\nThe small business managers handled the pandemic in a way that worked well in their contexts, and the pandemic generally did not have a negative effect on their businesses or themselves. A salutogenic approach, through which the managers focused on identifying and using resources, was an important factor for managing stressors and adversity during the pandemic. Hence, the concept of salutogenesis may be used as an intervention to foster better health in small businesses, both at a personal and organisational level in order to handle future challenges effectively.", "doi": "10.1371/journal.pone.0265029", "pmid": "35302995", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-40328"}, {"db": "pmc", "key": "PMC8932562"}], "notes": [], "created": "2022-04-04T07:20:30.481Z", "modified": "2022-11-22T05:39:10.634Z"}, {"entity": "publication", "iuid": "d40245a393af4e258f8aeb8480b67790", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d40245a393af4e258f8aeb8480b67790.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d40245a393af4e258f8aeb8480b67790"}}, "title": "Associations between hemostatic markers and mortality in COVID-19 - Compounding effects of D-dimer, antithrombin and PAP complex.", "authors": [{"family": "Bokn\u00e4s", "given": "Niklas", "initials": "N"}, {"family": "Laine", "given": "Cia", "initials": "C"}, {"family": "Hillarp", "given": "Andreas", "initials": "A"}, {"family": "Macwan", "given": "Ankit S", "initials": "AS"}, {"family": "Gustafsson", "given": "Kerstin M", "initials": "KM"}, {"family": "Lindahl", "given": "Tomas L", "initials": "TL"}, {"family": "Holmstr\u00f6m", "given": "Margareta", "initials": "M"}], "type": "journal article", "published": "2022-03-18", "journal": {"title": "Thromb Res", "issn": "1879-2472", "volume": "213", "pages": "97-104", "issn-l": "0049-3848"}, "abstract": "In this single-center cohort study, we applied a panel of laboratory markers to characterize hemostatic function in 217 consecutive patients that underwent testing for COVID-19 as they were admitted to Link\u00f6ping University Hospital between April and June 2020. In the 96 patients that tested positive for SARS-CoV-2 (COVID-19+), the cumulative incidences of death and venous thromboembolism were 24.0% and 19.8% as compared to 12.4% (p = 0.031) and 11.6% (p = 0.13) in the 121 patients that tested negative (COVID-19-). In COVID-19+ patients, we found pronounced increases in plasma levels of von Willebrand factor (vWF) and fibrinogen. Excess mortality was observed in COVID-19+ patients with the following aberrations in hemostatic markers: high D-dimer, low antithrombin or low plasmin-antiplasmin complex (PAP) formation, with Odds Ratios (OR) for death of 4.7 (95% confidence interval (CI95) 1.7-12.9; p = 0.003) for D-dimer >0.5 mg/L, 5.9 (CI95 1.8-19.7; p = 0.004) for antithrombin (AT) \u02c20.85 kIU/l and 4.9 (CI95 1.3-18.3; p = 0.019) for PAP < 1000 \u03bcg/L. Compounding increases in mortality was observed in COVID-19+ patients with combined defects in markers of fibrinolysis and coagulation, with ORs for death of 15.7 (CI95 4.3-57; p < 0.001) for patients with PAP <1000 \u03bcg/L and D-dimer >0.5 mg/L and 15.5 (CI95 2.8-87, p = 0.002) for patients with PAP <1000 \u03bcg/L and AT \u02c20.85 kIU/L. We observed an elevated fraction of incompletely degraded D-dimer fragments in COVID-19+ patients with low PAP, indicating impaired fibrinolytic breakdown of cross-linked fibrin.", "doi": "10.1016/j.thromres.2022.03.013", "pmid": "35316719", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0049-3848(22)00090-1"}, {"db": "pmc", "key": "PMC8930184"}], "notes": [], "created": "2022-03-23T06:13:34.273Z", "modified": "2022-04-04T07:11:04.402Z"}, {"entity": "publication", "iuid": "4b29cfb92af74ba9bb0ae2d414a33423", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b29cfb92af74ba9bb0ae2d414a33423.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b29cfb92af74ba9bb0ae2d414a33423"}}, "title": "Digit ratios and their asymmetries as risk factors of developmental instability and hospitalization for COVID-19.", "authors": [{"family": "Kasielska-Trojan", "given": "A", "initials": "A"}, {"family": "Manning", "given": "J T", "initials": "JT"}, {"family": "Jab\u0142kowski", "given": "M", "initials": "M"}, {"family": "Bia\u0142kowska-Warzecha", "given": "J", "initials": "J"}, {"family": "Hirschberg", "given": "A L", "initials": "AL"}, {"family": "Antoszewski", "given": "B", "initials": "B"}], "type": "journal article", "published": "2022-03-17", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "4573", "issn-l": "2045-2322"}, "abstract": "COVID-19 presents with mild symptoms in the majority of patients but in a minority it progresses to acute illness and hospitalization. Here we consider whether markers for prenatal sex hormones and postnatal stressors on developmental instability, i.e. digit ratios and their directional and unsigned asymmetries, are predictive of hospitalization. We focus on six ratios: 2D:3D; 2D:4D; 2D:5D; 3D:4D; 3D:5D; 4D:5D and compare hospitalized patient and control means for right, and left ratios, directional asymmetries (right-left) and unsigned asymmetries [|(right-left)|]. There were 54 patients and 100 controls. We found (i) patients differed in their digit ratios from controls (patients > controls) in all three ratios that included 5D (2D:5D, 3D:5D and 4D:5D) with small to medium effect sizes (d = 0.3 to 0.64), (ii) they did not differ in their directional asymmetries, and (iii) patients had greater |(right-left)| asymmetry than controls for 2D:4D (d = .74) , and all ratios that included 5D; 2D:5D (d = 0.66), 3D:5D (d = .79), 4D:5D (d = 0.47). The Composite Asymmetry of the two largest effects (2D:4D + 3D:5D) gave a patient and control difference with effect size d = 1.04. All patient versus control differences were independent of sex. We conclude that digit ratio patterns differ between patients and controls and this was most evident in ratios that included 5D. Large |(right-left)| asymmetries in the patients are likely to be a marker for postnatal stressors resulting in developmental perturbations and for potential severity of COVID-19.", "doi": "10.1038/s41598-022-08646-7", "pmid": "35301404", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-08646-7"}, {"db": "pmc", "key": "PMC8931101"}], "notes": [], "created": "2022-04-04T07:21:16.821Z", "modified": "2022-04-04T07:21:16.836Z"}, {"entity": "publication", "iuid": "149cb301610f424897b07ab7001e9771", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/149cb301610f424897b07ab7001e9771.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/149cb301610f424897b07ab7001e9771"}}, "title": "Prophylactic anticoagulation with low molecular weight heparin in COVID-19: cohort studies in Denmark and Sweden.", "authors": [{"family": "Lund", "given": "Lars Christian", "initials": "LC"}, {"family": "Hedberg", "given": "Pontus", "initials": "P"}, {"family": "Andreasen", "given": "Anne Helms", "initials": "AH"}, {"family": "Petersen", "given": "Janne", "initials": "J"}, {"family": "Petersen", "given": "Tonny Studsgaard", "initials": "TS"}, {"family": "Potteg\u00e5rd", "given": "Anton", "initials": "A"}, {"family": "Bodilsen", "given": "Jacob", "initials": "J"}, {"family": "Naucler", "given": "Pontus", "initials": "P"}, {"family": "Hallas", "given": "Jesper", "initials": "J"}, {"family": "Jimenez-Solem", "given": "Espen", "initials": "E"}], "type": "journal article", "published": "2022-03-16", "journal": {"title": "Clin Microbiol Infect", "issn": "1469-0691", "issn-l": null}, "abstract": "To evaluate safety and effectiveness of prophylactic anticoagulation with low molecular weight heparin (LMWH) in individuals hospitalised for COVID-19.\n\nUsing healthcare records from the capital region of Denmark (March 2020-February 2021) and Karolinska University Hospital in Sweden (February 2020-September 2021), we conducted an observational cohort study comparing clinical outcomes 30 days after admission among individuals hospitalised for COVID-19 starting prophylactic LMWH during the first 48 hours of hospitalisation with outcomes among those not receiving prophylactic anticoagulation. We used inverse probability weighting to adjust for confounders and bias due to missing information. Risk ratios, risk differences and robust 95% confidence intervals (CI) were estimated using binomial regression. Country-specific risk ratios were pooled using random-effects meta-analysis.\n\nWe included 1692 and 1868 individuals in the Danish and Swedish cohorts. Of these, 771 (46%) and 1167 (62%) received prophylactic LMWH up to 48 hours after admission. The combined mortality in Denmark and Sweden was 12% (N=432) and the pooled risk ratio was 0.89 (CI 0.61-1.29) comparing individuals who received LMWH to those who did not. The relative risk of ICU admission was 1.12 (CI 0.85-1.48), while we observed no increased risk of bleeding (RR 0.60, 0.14-2.59). The relative risk of venous thromboembolism was 0.68 (CI: 0.33-1.38) in Sweden. Less than 5 VTE events were observed among individuals receiving LMWH in Denmark, preventing a meaningful analysis.\n\nWe found no benefit on mortality with prophylactic LMWH and no increased risk of bleeding among COVID-19 patients receiving prophylactic LMWH.", "doi": "10.1016/j.cmi.2022.03.006", "pmid": "35306190", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(22)00145-8"}, {"db": "pmc", "key": "PMC8926439"}], "notes": [], "created": "2022-03-23T06:15:58.305Z", "modified": "2022-04-04T07:11:58.553Z"}, {"entity": "publication", "iuid": "c535676ff3714e12a544dc95d815f7e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c535676ff3714e12a544dc95d815f7e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c535676ff3714e12a544dc95d815f7e7"}}, "title": "Exposure-lag response of air temperature on COVID-19 incidence in twelve Italian cities: A meta-analysis.", "authors": [{"family": "Fong", "given": "Fang Chyi", "initials": "FC"}, {"family": "Smith", "given": "Daniel Robert", "initials": "DR"}], "type": "journal article", "published": "2022-03-16", "journal": {"title": "Environ Res", "issn": "1096-0953", "pages": "113099", "volume": "212", "issue": "Pt A", "issn-l": "0013-9351"}, "abstract": "The exposure-lag response of air temperature on daily COVID-19 incidence is unclear and there have been concerns regarding the robustness of previous studies. Here we present an analysis of high spatial and temporal resolution using the distributed lag non-linear modelling (DLNM) framework. Utilising nearly two years' worth of data, we fit statistical models to twelve Italian cities to quantify the delayed effect of air temperature on daily COVID-19 incidence, accounting for several categories of potential confounders (meteorological, air quality and non-pharmaceutical interventions). Coefficients and covariance matrices for the temperature term were then synthesised using random effects meta-analysis to yield pooled estimates of the exposure-lag response with effects presented as the relative risk (RR) and cumulative RR (RRcum). The cumulative exposure response curve was non-linear, with peak risk at 15.1 \u00b0C and declining risk at progressively lower and higher temperatures. The lowest RRcum at 0.2 \u00b0C is 0.72 [0.56,0.91] times that of the highest risk. Due to this non-linearity, the shape of the lag response curve necessarily varied by temperature. This work suggests that on a given day, air temperature approximately 15 \u00b0C maximises the incidence of COVID-19, with the effects distributed in the subsequent ten days or more.", "doi": "10.1016/j.envres.2022.113099", "pmid": "35305982", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0013-9351(22)00426-1"}, {"db": "pmc", "key": "PMC8925100"}], "notes": [], "created": "2022-03-23T06:16:18.024Z", "modified": "2022-04-04T07:12:12.668Z"}, {"entity": "publication", "iuid": "426e7a01cb93430a878e86cc81edeaf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/426e7a01cb93430a878e86cc81edeaf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/426e7a01cb93430a878e86cc81edeaf3"}}, "title": "Assessing alternative indicators for Covid-19 policy evaluation, with a counterfactual for Sweden.", "authors": [{"family": "Latour", "given": "Chiara", "initials": "C"}, {"family": "Peracchi", "given": "Franco", "initials": "F", "orcid": "0000-0002-4532-6173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b566a37c94d948abbfbe9edc508cc440.json"}}, {"family": "Spagnolo", "given": "Giancarlo", "initials": "G", "orcid": "0000-0003-4117-6283", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd25c165fd0d474d9c6dc385bd27939b.json"}}], "type": "journal article", "published": "2022-03-16", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "3", "pages": "e0264769", "issn-l": "1932-6203"}, "abstract": "Using the synthetic control method, we construct counterfactuals for what would have happened if Sweden had imposed a lockdown during the first wave of the COVID-19 epidemic. We consider eight different indicators, including a novel one that we construct by adjusting recorded daily COVID-19 deaths to account for weakly excess mortality. Correcting for data problems and re-optimizing the synthetic control for each indicator, we find that a lockdown would have had sizable effects within one week. The much longer delay estimated by two previous studies focusing on the number of positives cases is mainly driven by the extremely low testing frequency that prevailed in Sweden in the first months of the epidemic. This result appears relevant for choosing the timing of future lockdowns and highlights the importance of looking at several indicators to derive robust conclusions. We also find that our novel indicator is effective in correcting errors in the COVID-19 deaths series and that the quantitative effects of the lockdown are stronger than previously estimated.", "doi": "10.1371/journal.pone.0264769", "pmid": "35294472", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8926176"}, {"db": "pii", "key": "PONE-D-21-23290"}], "notes": [], "created": "2023-01-13T13:38:34.149Z", "modified": "2023-01-13T13:38:34.233Z"}, {"entity": "publication", "iuid": "cd0e2a2c31544e2496d2efd2a4b773e3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd0e2a2c31544e2496d2efd2a4b773e3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd0e2a2c31544e2496d2efd2a4b773e3"}}, "title": "Application of the SARS-CoV-2-S1 ACE-2 receptor interaction as the basis of the fully automated assay to detect neutralizing SARS-CoV-2-S1 antibodies in blood samples.", "authors": [{"family": "Filchtinski", "given": "Daniel", "initials": "D"}, {"family": "Sundberg", "given": "Magnus", "initials": "M"}, {"family": "Berthold", "given": "Heike", "initials": "H"}, {"family": "Steller", "given": "Laura", "initials": "L"}, {"family": "Kayser", "given": "Jos\u00e9", "initials": "J"}, {"family": "Holz", "given": "Sanja", "initials": "S"}, {"family": "Hinze", "given": "Mario", "initials": "M"}, {"family": "Braeutigam", "given": "Oxana", "initials": "O"}, {"family": "Schulte-Pelkum", "given": "Johannes", "initials": "J"}, {"family": "Fiedler", "given": "Raimund", "initials": "R"}], "type": "journal article", "published": "2022-03-15", "journal": {"title": "J Immunol Methods", "issn": "1872-7905", "volume": "504", "pages": "113258", "issn-l": null}, "abstract": "A quantitative, high throughput, fully automated diagnostic method for the detection of neutralizing anti-SARS-CoV-2 antibodies was developed on the Phadia system based on the interaction of SARS-CoV-2 S1 protein and the human ACE-2 receptor. This method was compared to the current state of the art plaque reduction neutralization test (PRNT) and a high correlation between the two methods was observed. Using a large cohort of blood samples from convalescent patients and controls the method displays very high sensitivity and specificity (99,8% and 99.99%, respectively). Neutralizing antibody titers of mRNA-1273 and BNT162b2-vaccinated persons can also be quantified with this method as well. This fully automated method provides the possibility to determine anti-SARS-CoV-2 neutralizing antibody concentrations in just 2 h.", "doi": "10.1016/j.jim.2022.113258", "pmid": "35304119", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0022-1759(22)00045-X"}, {"db": "pmc", "key": "PMC8923036"}], "notes": [], "created": "2022-04-04T07:19:52.436Z", "modified": "2022-04-04T07:19:52.472Z"}, {"entity": "publication", "iuid": "93c162d21f494e0a9e1a42eda9e6db43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/93c162d21f494e0a9e1a42eda9e6db43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/93c162d21f494e0a9e1a42eda9e6db43"}}, "title": "Structure-based drug repurposing: Traditional and advanced AI/ML-aided methods.", "authors": [{"family": "Choudhury", "given": "Chinmayee", "initials": "C"}, {"family": "Arul Murugan", "given": "N", "initials": "N"}, {"family": "Deva Priyakumar", "given": "U", "initials": "U"}], "type": "journal article", "published": "2022-03-14", "journal": {"title": "Drug Discov Today", "issn": "1878-5832", "issn-l": null}, "abstract": "The current global health emergency in the form of the Coronavirus 2019 (COVID-19) pandemic has highlighted the need for fast, accurate, and efficient drug discovery pipelines. Traditional drug discovery projects relying on in vitro high-throughput screening (HTS) involve large investments and sophisticated experimental set-ups, affordable only to big biopharmaceutical companies. In this scenario, application of efficient state-of-the-art computational methods and modern artificial intelligence (AI)-based algorithms for rapid screening of repurposable chemical space [approved drugs and natural products (NPs) with proven pharmacokinetic profiles] to identify the initial leads is a powerful option to save resources and time. Structure-based drug repurposing is a popular in silico repurposing approach. In this review, we discuss traditional and modern AI-based computational methods and tools applied at various stages for structure-based drug discovery (SBDD) pipelines. Additionally, we highlight the role of generative models in generating molecules with scaffolds from repurposable chemical space.", "doi": "10.1016/j.drudis.2022.03.006", "pmid": "35301148", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1359-6446(22)00112-X"}, {"db": "pmc", "key": "PMC8920090"}], "notes": [], "created": "2022-04-04T07:21:32.874Z", "modified": "2022-04-04T07:21:32.888Z"}, {"entity": "publication", "iuid": "0fc4043c324c449ca2012a1bbf06b59d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0fc4043c324c449ca2012a1bbf06b59d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0fc4043c324c449ca2012a1bbf06b59d"}}, "title": "Inhibition of the main protease of SARS-CoV-2 (Mpro) by repurposing/designing drug-like substances and utilizing nature's toolbox of bioactive compounds.", "authors": [{"family": "Antonopoulou", "given": "Io", "initials": "I"}, {"family": "Sapountzaki", "given": "Eleftheria", "initials": "E"}, {"family": "Rova", "given": "Ulrika", "initials": "U"}, {"family": "Christakopoulos", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2022-03-14", "journal": {"title": "Comput Struct Biotechnol J", "issn": "2001-0370", "volume": "20", "pages": "1306-1344", "issn-l": "2001-0370"}, "abstract": "The emergence of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has resulted in a long pandemic, with numerous cases and victims worldwide and enormous consequences on social and economic life. Although vaccinations have proceeded and provide a valuable shield against the virus, the approved drugs are limited and it is crucial that further ways to combat infection are developed, that can also act against potential mutations. The main protease (Mpro) of the virus is an appealing target for the development of inhibitors, due to its importance in the viral life cycle and its high conservation among different coronaviruses. Several compounds have shown inhibitory potential against Mpro, both in silico and in vitro, with few of them also having entered clinical trials. These candidates include: known drugs that have been repurposed, molecules specifically designed based on the natural substrate of the protease or on structural moieties that have shown high binding affinity to the protease active site, as well as naturally derived compounds, either isolated or in plant extracts. The aim of this work is to collectively present the results of research regarding Mpro inhibitors to date, focusing on the function of the compounds founded by in silico simulations and further explored by in vitro and in vivo assays. Creating an extended portfolio of promising compounds that may block viral replication by inhibiting Mpro and by understanding involved structure-activity relationships, could provide a basis for the development of effective solutions against SARS-CoV-2 and future related outbreaks.", "doi": "10.1016/j.csbj.2022.03.009", "pmid": "35308802", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2001-0370(22)00084-8"}, {"db": "pmc", "key": "PMC8920478"}], "notes": [], "created": "2022-03-23T06:14:41.590Z", "modified": "2022-04-04T07:11:33.427Z"}, {"entity": "publication", "iuid": "b5e110e4d36741ee9862c91028d624df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5e110e4d36741ee9862c91028d624df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5e110e4d36741ee9862c91028d624df"}}, "title": "Natural SARS-CoV-2 Infection Affects Neutralizing Activity in Saliva of Vaccinees.", "authors": [{"family": "Garziano", "given": "Micaela", "initials": "M"}, {"family": "Utyro", "given": "Olga", "initials": "O"}, {"family": "Poliseno", "given": "Mariacristina", "initials": "M"}, {"family": "Santantonio", "given": "Teresa Antonia", "initials": "TA"}, {"family": "Saulle", "given": "Irma", "initials": "I"}, {"family": "Strizzi", "given": "Sergio", "initials": "S"}, {"family": "Lo Caputo", "given": "Sergio", "initials": "S"}, {"family": "Clerici", "given": "Mario", "initials": "M"}, {"family": "Introini", "given": "Andrea", "initials": "A"}, {"family": "Biasin", "given": "Mara", "initials": "M"}], "type": "journal article", "published": "2022-03-11", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "13", "pages": "820250", "issn-l": "1664-3224"}, "abstract": "SARS-CoV-2 transmission mainly occurs through exposure of the upper airway mucosa to infected secretions such as saliva, which are excreted by an infected person. Thus, oral mucosal immunity plays a central role in the prevention of and early defense against SARS-CoV-2 infection. Although virus-specific antibody response has been extensively investigated in blood samples of SARS-CoV-2-infected patients and vaccinees, local humoral immunity in the oral cavity and its relationship to systemic antibody levels needs to be further addressed.\n\nWe fine-tuned a virus neutralization assay (vNTA) to measure the neutralizing activity (NA) of plasma and saliva samples from 20 SARS-CoV-2-infected (SI), 40 SARS-CoV-2-vaccinated (SV), and 28 SARS-CoV-2-vaccinated subjects with a history of infection (SIV) using the \"wild type\" SARS-CoV-2 lineage B.1 (EU) and the Delta (B.1.617.2) strains. To validate the vNTA results, the presence of neutralizing antibodies (NAbs) to the spike receptor binding domain (RBD) was evaluated with an ELISA assay.\n\nNA to SARS-CoV-2 lineage B.1 (EU) was present in plasma samples from all the tested subjects, with higher titers in SIV compared to both SI and SV. Conversely, NA was detected in saliva samples from 10.3% SV, 45% SI, and 92.6% SIV, with significantly lower titers in SV compared to both SI and SIV. The detection of NAbs in saliva reflected its reduced NA in SV.\n\nThe difference in NA of plasma vs. saliva was confirmed in a vNTA where the SARS-CoV-2 B.1 and Delta strains were tested head-to-head, which also revealed a reduced NA of both specimens compared to the B.1 variant.\n\nThe administration of SARS-CoV-2 vaccines was associated with limited virus NA in the oral cavity, as measured in saliva and in comparison to plasma. This difference was more evident in vaccinees without a history of SARS-CoV-2 infection, possibly highlighting the importance of local exposure at the site of virus acquisition to effectively prevent the infection and block its spread. Nevertheless, the presence of immune escape mutations as possibly represented by the SARS-CoV-2 Delta variant negatively affects both local and systemic efficacy of NA associated with vaccination.", "doi": "10.3389/fimmu.2022.820250", "pmid": "35359971", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8962193"}], "notes": [], "created": "2022-04-04T06:33:12.170Z", "modified": "2022-04-04T06:33:12.183Z"}, {"entity": "publication", "iuid": "1baee0c983ad45ff89c7121e577fd912", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1baee0c983ad45ff89c7121e577fd912.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1baee0c983ad45ff89c7121e577fd912"}}, "title": "Experimental Model of Pulmonary Inflammation Induced by SARS-CoV-2 Spike Protein and Endotoxin.", "authors": [{"family": "Puthia", "given": "Manoj", "initials": "M", "orcid": "0000-0001-6048-7234", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9570effdcf284ffdb350c082fc830dac.json"}}, {"family": "Tanner", "given": "Lloyd", "initials": "L"}, {"family": "Petruk", "given": "Ganna", "initials": "G"}, {"family": "Schmidtchen", "given": "Artur", "initials": "A", "orcid": "0000-0001-9209-3141", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/426e00c7c8314ea195f2670af469e19a.json"}}], "type": "journal article", "published": "2022-03-11", "journal": {"title": "ACS Pharmacol. Transl. Sci.", "issn": "2575-9108", "volume": "5", "issue": "3", "pages": "141-148", "issn-l": null}, "abstract": "COVID-19 is characterized by a dysregulated and excessive inflammatory response and, in severe cases, acute respiratory distress syndrome. We have recently demonstrated a previously unknown high-affinity interaction between the SARS-CoV-2 spike (S) protein and bacterial lipopolysaccharide (LPS), leading to the boosting of inflammation. Here we present a mouse inflammation model employing the coadministration of aerosolized S protein together with LPS to the lungs. Using NF-\u03baB-RE-Luc reporter and C57BL/6 mice followed by combinations of bioimaging, cytokine, chemokine, fluorescence-activated cell sorting, and histochemistry analyses, we show that the model yields severe pulmonary inflammation and a cytokine profile similar to that observed in COVID-19. Therefore, the model offers utility for analyses of the pathophysiological features of COVID-19 and the development of new treatments.", "doi": "10.1021/acsptsci.1c00219", "pmid": "35774232", "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC9239546"}], "notes": [], "created": "2022-08-17T13:13:35.479Z", "modified": "2022-08-17T13:13:35.592Z"}, {"entity": "publication", "iuid": "5e5f888e68164ea493149edbf81b7f7d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e5f888e68164ea493149edbf81b7f7d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e5f888e68164ea493149edbf81b7f7d"}}, "title": "Efficacy of Adaptogens in Patients with Long COVID-19: A Randomized, Quadruple-Blind, Placebo-Controlled Trial.", "authors": [{"family": "Karosanidze", "given": "Irina", "initials": "I"}, {"family": "Kiladze", "given": "Ushangi", "initials": "U"}, {"family": "Kirtadze", "given": "Nino", "initials": "N"}, {"family": "Giorgadze", "given": "Mikhail", "initials": "M"}, {"family": "Amashukeli", "given": "Nana", "initials": "N"}, {"family": "Parulava", "given": "Nino", "initials": "N"}, {"family": "Iluridze", "given": "Neli", "initials": "N"}, {"family": "Kikabidze", "given": "Nana", "initials": "N"}, {"family": "Gudavadze", "given": "Nana", "initials": "N"}, {"family": "Gelashvili", "given": "Lali", "initials": "L"}, {"family": "Koberidze", "given": "Vazha", "initials": "V"}, {"family": "Gigashvili", "given": "Eka", "initials": "E"}, {"family": "Jajanidze", "given": "Natela", "initials": "N"}, {"family": "Latsabidze", "given": "Naira", "initials": "N"}, {"family": "Mamageishvili", "given": "Nato", "initials": "N"}, {"family": "Shengelia", "given": "Ramaz", "initials": "R"}, {"family": "Hovhannisyan", "given": "Areg", "initials": "A"}, {"family": "Panossian", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8467-4525", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86a40ce1842b4c289c7f09c955ad4325.json"}}], "type": "journal article", "published": "2022-03-11", "journal": {"title": "Pharmaceuticals (Basel)", "issn": "1424-8247", "volume": "15", "issue": "3", "issn-l": null}, "abstract": "Currently, no effective treatment of comorbid complications or COVID-19 long-haulers during convalescence is known. This randomized, quadruple-blind, placebo-controlled trial aimed to assess the efficacy of adaptogens on the recovery of patients with Long COVID symptoms. One hundred patients with confirmed positive SARS-CoV-2 test, discharged from COVID Hotel isolation, Intensive Care Unit (ICU), or Online Clinics, and who experienced at least three of nine Long COVID symptoms (fatigue, headache, respiratory insufficiency, cognitive performance, mood disorders, loss of smell, taste, and hair, sweatiness, cough, pain in joints, muscles, and chest) in the 30 days before randomization were included in the study of the efficacy of Chisan\u00ae/ADAPT-232 (a fixed combination of adaptogens Rhodiola, Eleutherococcus, and Schisandra) supplementation for two weeks. Chisan\u00ae decreased the duration of fatigue and pain for one and two days, respectively, in 50% of patients. The number of patients with lack of fatigue and pain symptoms was significantly less in the Chisan\u00ae treatment group than in the placebo group on Days 9 (39% vs. 57%, pain relief, p = 0.0019) and 11 (28% vs. 43%, relief of fatigue, * p = 0.0157). Significant relief of severity of all Long COVID symptoms over the time of treatment and the follow-up period was observed in both groups of patients, notably decreasing the level of anxiety and depression from mild and moderate to normal, as well as increasing cognitive performance in patients in the d2 test for attention and increasing their physical activity and workout (daily walk time). However, the significant difference between placebo and Chisan\u00ae treatment was observed only with a workout (daily walk time) and relieving respiratory insufficiency (cough). A clinical assessment of blood markers of the inflammatory response (C-reactive protein) and blood coagulation (D-dimer) did not reveal any significant difference over time between treatment groups except significantly lower IL-6 in the Chisan\u00ae treatment group. Furthermore, a significant difference between the placebo and Chisan\u00ae treatment was observed for creatinine: Chisan\u00ae significantly decreased blood creatinine compared to the placebo, suggesting prevention of renal failure progression in Long COVID. In this study, we, for the first time, demonstrate that adaptogens can increase physical performance in Long COVID and reduce the duration of fatigue and chronic pain. It also suggests that Chisan\u00ae/ADAPT-232 might be useful for preventing the progression of renal failure associated with increasing creatinine.", "doi": "10.3390/ph15030345", "pmid": "35337143", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "ph15030345"}, {"db": "pmc", "key": "PMC8953947"}], "notes": [], "created": "2022-04-04T06:51:25.997Z", "modified": "2022-04-04T06:51:26.077Z"}, {"entity": "publication", "iuid": "2e67f1e6d6c64aa2a85ac23ba45946a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e67f1e6d6c64aa2a85ac23ba45946a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e67f1e6d6c64aa2a85ac23ba45946a1"}}, "title": "How the Innate Immune System of the Blood Contributes to Systemic Pathology in COVID-19-Induced ARDS and Provides Potential Targets for Treatment.", "authors": [{"family": "Nilsson", "given": "Bo", "initials": "B"}, {"family": "Persson", "given": "Barbro", "initials": "B"}, {"family": "Eriksson", "given": "Oskar", "initials": "O"}, {"family": "Fromell", "given": "Karin", "initials": "K"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Huber-Lang", "given": "Markus", "initials": "M"}, {"family": "Ekdahl", "given": "Kristina N", "initials": "KN"}], "type": "journal article", "published": "2022-03-08", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "13", "issue": null, "pages": "840137"}, "abstract": "Most SARS-CoV-2 infected patients experience influenza-like symptoms of low or moderate severity. But, already in 2020 early during the pandemic it became obvious that many patients had a high incidence of thrombotic complications, which prompted treatment with high doses of low-molecular-weight heparin (LMWH; typically 150-300IU/kg) to prevent thrombosis. In some patients, the disease aggravated after approximately 10 days and turned into a full-blown acute respiratory distress syndrome (ARDS)-like pulmonary inflammation with endothelialitis, thrombosis and vascular angiogenesis, which often lead to intensive care treatment with ventilator support. This stage of the disease is characterized by dysregulation of cytokines and chemokines, in particular with high IL-6 levels, and also by reduced oxygen saturation, high risk of thrombosis, and signs of severe pulmonary damage with ground glass opacities. The direct link between SARS-CoV-2 and the COVID-19-associated lung injury is not clear. Indirect evidence speaks in favor of a thromboinflammatory reaction, which may be initiated by the virus itself and by infected damaged and/or apoptotic cells. We and others have demonstrated that life-threatening COVID-19 ARDS is associated with a strong activation of the intravascular innate immune system (IIIS). In support of this notion is that activation of the complement and kallikrein/kinin (KK) systems predict survival, the necessity for usage of mechanical ventilation, acute kidney injury and, in the case of MBL, also coagulation system activation with thromboembolism. The general properties of the IIIS can easily be translated into mechanisms of COVID-19 pathophysiology. The prognostic value of complement and KKsystem biomarkers demonstrate that pharmaceuticals, which are licensed or have passed the phase I trial stage are promising candidate drugs for treatment of COVID-19. Examples of such compounds include complement inhibitors AMY-101 and eculizumab (targeting C3 and C5, respectively) as well as kallikrein inhibitors ecallantide and lanadelumab and the bradykinin receptor (BKR) 2 antagonist icatibant. In this conceptual review we discuss the activation, crosstalk and the therapeutic options that are available for regulation of the IIIS.", "doi": "10.3389/fimmu.2022.840137", "pmid": "35350780", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8957861"}], "notes": [], "created": "2022-04-04T06:37:36.306Z", "modified": "2022-08-19T12:35:35.442Z"}, {"entity": "publication", "iuid": "f1049c44123e48d9bf373c9e55a0808c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1049c44123e48d9bf373c9e55a0808c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1049c44123e48d9bf373c9e55a0808c"}}, "title": "Alphacoronavirus in a Daubenton's Myotis Bat (Myotis daubentonii) in Sweden.", "authors": [{"family": "Lwande", "given": "Olivia Wesula", "initials": "OW"}, {"family": "Thalin", "given": "Therese", "initials": "T"}, {"family": "de Jong", "given": "Johnny", "initials": "J"}, {"family": "Sj\u00f6din", "given": "Andreas", "initials": "A", "orcid": "0000-0001-5350-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea9e0de5833a4fb8b1a0039f80d75497.json"}}, {"family": "N\u00e4slund", "given": "Jonas", "initials": "J", "orcid": "0000-0002-4980-913X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6df0e6caa2340bb83bdf02c8fda67d1.json"}}, {"family": "Evander", "given": "Magnus", "initials": "M", "orcid": "0000-0001-6034-4807", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a6d141b52d747d2a63e32e1b2a2ff3d.json"}}, {"family": "Ecke", "given": "Frauke", "initials": "F", "orcid": "0000-0003-4208-345X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2e4af95902b4c45aeb2b0290fe70ebb.json"}}], "type": "journal article", "published": "2022-03-08", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "3", "issn-l": "1999-4915"}, "abstract": "The ongoing COVID-19 pandemic has stimulated a search for reservoirs and species potentially involved in back and forth transmission. Studies have postulated bats as one of the key reservoirs of coronaviruses (CoVs), and different CoVs have been detected in bats. So far, CoVs have not been found in bats in Sweden and we therefore tested whether they carry CoVs. In summer 2020, we sampled a total of 77 adult bats comprising 74 Myotis daubentonii, 2 Pipistrellus pygmaeus, and 1 M. mystacinus bats in southern Sweden. Blood, saliva and feces were sampled, processed and subjected to a virus next-generation sequencing target enrichment protocol. An Alphacoronavirus was detected and sequenced from feces of a M. daubentonii adult female bat. Phylogenetic analysis of the almost complete virus genome revealed a close relationship with Finnish and Danish strains. This was the first finding of a CoV in bats in Sweden, and bats may play a role in the transmission cycle of CoVs in Sweden. Focused and targeted surveillance of CoVs in bats is warranted, with consideration of potential conflicts between public health and nature conservation required as many bat species in Europe are threatened and protected.", "doi": "10.3390/v14030556", "pmid": "35336963", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "v14030556"}, {"db": "pmc", "key": "PMC8953627"}], "notes": [], "created": "2022-04-04T06:51:48.847Z", "modified": "2022-04-04T06:52:01.079Z"}, {"entity": "publication", "iuid": "9af12608a3ea4e4fbf5519d7c128dbe6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9af12608a3ea4e4fbf5519d7c128dbe6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9af12608a3ea4e4fbf5519d7c128dbe6"}}, "title": "The Impact of COVID-19 Confinement on Tinnitus and Hearing Loss in Older Adults: Data From the LOST in Lombardia Study.", "authors": [{"family": "Jarach", "given": "Carlotta Micaela", "initials": "CM"}, {"family": "Lugo", "given": "Alessandra", "initials": "A"}, {"family": "Stival", "given": "Chiara", "initials": "C"}, {"family": "Bosetti", "given": "Cristina", "initials": "C"}, {"family": "Amerio", "given": "Andrea", "initials": "A"}, {"family": "Cavalieri d'Oro", "given": "Luca", "initials": "L"}, {"family": "Iacoviello", "given": "Licia", "initials": "L"}, {"family": "Odone", "given": "Anna", "initials": "A"}, {"family": "Stuckler", "given": "David", "initials": "D"}, {"family": "Zucchi", "given": "Alberto", "initials": "A"}, {"family": "van den Brandt", "given": "Piet", "initials": "P"}, {"family": "Garavello", "given": "Werner", "initials": "W"}, {"family": "Cederroth", "given": "Christopher R", "initials": "CR"}, {"family": "Schlee", "given": "Winfried", "initials": "W"}, {"family": "Gallus", "given": "Silvano", "initials": "S"}, {"family": "LOST in Lombardia Study Investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2022-03-07", "journal": {"title": "Front Neurol", "issn": "1664-2295", "volume": "13", "pages": "838291", "issn-l": null}, "abstract": "Although a direct relationship between tinnitus or hearing difficulties and COVID-19 has been suggested, current literature provides inconsistent results, and no research has been undertaken in older adults.\n\nIn November 2020, we conducted the LOST in Lombardia survey, a telephone-based cross-sectional study on a sample of 4,400 individuals representative of the general population aged \u226565 years from Lombardy region, Northern Italy. Individuals with diagnosed tinnitus and/or hearing loss were asked whether their conditions had improved or deteriorated in 2020 compared to 2019.\n\nOverall, 8.1% of older adults reported a diagnosis of tinnitus and 10.5% of hearing loss. In 2020 compared to 2019, among individuals with tinnitus, those with increasing severity (5.0%) were similar to those decreasing it (5.3%). Among individuals with hearing loss, more people reported an increase (13.6%) than a decrease (3.2%) in their disease severity. No individual with a diagnosis in 2020 of tinnitus (n = 6) or hearing loss (n = 13) had COVID-19. The incidence of tinnitus was lower in 2020 (rate: 14.8 per 10,000 person-years) than in previous years (rate in 1990-2019: 36.0 per 10,000 person-years; p = 0.026). There was no change in the incidence of hearing loss (p = 0.134).\n\nIn this large representative sample of older adults, on average neither COVID-19 confinement nor SARS-CoV-2 infection appeared to increase the severity or incidence of tinnitus. The increased severity of hearing difficulties may totally or partially be explained by physiologic deterioration of the condition, or by a misperception due to the use of face-masks.", "doi": "10.3389/fneur.2022.838291", "pmid": "35330807", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8940241"}], "notes": [], "created": "2022-04-04T06:59:19.890Z", "modified": "2022-04-04T06:59:19.929Z"}, {"entity": "publication", "iuid": "32408591666645588f30bb91a9bc5573", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/32408591666645588f30bb91a9bc5573.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/32408591666645588f30bb91a9bc5573"}}, "title": "Reduced immunogenicity of a third COVID-19 vaccination among recipients of allogeneic haematopoietic stem cell transplantation.", "authors": [{"family": "Einarsdottir", "given": "Sigrun", "initials": "S"}, {"family": "Martner", "given": "Anna", "initials": "A"}, {"family": "Nicklasson", "given": "Malin", "initials": "M"}, {"family": "Wiktorin", "given": "Hanna Grauers", "initials": "HG"}, {"family": "Arabpour", "given": "Mohammad", "initials": "M"}, {"family": "T\u00f6rnell", "given": "Andreas", "initials": "A"}, {"family": "Vaht", "given": "Krista", "initials": "K"}, {"family": "Waldenstr\u00f6m", "given": "Jesper", "initials": "J"}, {"family": "Ringlander", "given": "Johan", "initials": "J"}, {"family": "Bergstr\u00f6m", "given": "Tomas", "initials": "T"}, {"family": "Brune", "given": "Mats", "initials": "M"}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Lagging", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2022-03-03", "journal": {"title": "Haematologica", "issn": "1592-8721", "issn-l": null}, "abstract": "Not available.", "doi": "10.3324/haematol.2021.280494", "pmid": "35236057", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2022-03-04T06:18:44.595Z", "modified": "2022-03-04T06:19:05.660Z"}, {"entity": "publication", "iuid": "d160f1a1ac56447bbc94ec7cb9d00da0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d160f1a1ac56447bbc94ec7cb9d00da0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d160f1a1ac56447bbc94ec7cb9d00da0"}}, "title": "Human serum from SARS-CoV-2-vaccinated and COVID-19 patients shows reduced binding to the RBD of SARS-CoV-2 Omicron variant.", "authors": [{"family": "Schubert", "given": "Maren", "initials": "M", "orcid": "0000-0002-7041-9056", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/896d0278735a4c96b326666b36fd47c3.json"}}, {"family": "Bertoglio", "given": "Federico", "initials": "F", "orcid": "0000-0001-6477-1785", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f9424e832a44ce9b8482a128fbc91ae.json"}}, {"family": "Steinke", "given": "Stephan", "initials": "S", "orcid": "0000-0001-8559-954X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68ea5cf01e194e4383b0844d01e65f08.json"}}, {"family": "Heine", "given": "Philip Alexander", "initials": "PA", "orcid": "0000-0001-9643-6973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/084dfc2bbcb04ca98100923beb096ecb.json"}}, {"family": "Ynga-Durand", "given": "Mario Alberto", "initials": "MA", "orcid": "0000-0002-8586-3993", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bfb80f86d8c4fdabad58bedaea710f6.json"}}, {"family": "Maass", "given": "Henrike", "initials": "H"}, {"family": "Sammartino", "given": "Jos\u00e8 Camilla", "initials": "JC"}, {"family": "Cassaniti", "given": "Irene", "initials": "I"}, {"family": "Zuo", "given": "Fanglei", "initials": "F", "orcid": "0000-0002-4545-1265", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11312f803b4f49d6be77684a634b0caf.json"}}, {"family": "Du", "given": "Likun", "initials": "L", "orcid": "0000-0002-8448-2187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c03c88bf35744aa69ee3569394758ba6.json"}}, {"family": "Korn", "given": "Janin", "initials": "J"}, {"family": "Milo\u0161evi\u0107", "given": "Marko", "initials": "M"}, {"family": "Wenzel", "given": "Esther Veronika", "initials": "EV", "orcid": "0000-0002-6931-5612", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73e24d78e79d4952a3c188b0e8166bd6.json"}}, {"family": "Krstanovi\u0107", "given": "Fran", "initials": "F"}, {"family": "Polten", "given": "Saskia", "initials": "S"}, {"family": "Pribani\u0107-Mate\u0161i\u0107", "given": "Marina", "initials": "M"}, {"family": "Brizi\u0107", "given": "Ilija", "initials": "I"}, {"family": "Baldanti", "given": "Fausto", "initials": "F", "orcid": "0000-0002-3358-8969", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ad31c69d57a43b69e2a4d609d59ab0c.json"}}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "D\u00fcbel", "given": "Stefan", "initials": "S", "orcid": "0000-0001-8811-7390", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fdc38fd876784e20958f659bb25bdde4.json"}}, {"family": "\u0160usti\u0107", "given": "Alan", "initials": "A"}, {"family": "Marcotte", "given": "Harold", "initials": "H", "orcid": "0000-0002-7168-349X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e05b7b044674cc08cd2269ccf8c076e.json"}}, {"family": "Strengert", "given": "Monika", "initials": "M"}, {"family": "Proti\u0107", "given": "Alen", "initials": "A", "orcid": "0000-0002-6573-852X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41668eb51fb64576b6a864e9e7432f1f.json"}}, {"family": "Piralla", "given": "Antonio", "initials": "A"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q", "orcid": "0000-0003-1990-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94a32366862b470eba3a15521b9be290.json"}}, {"family": "\u010ci\u010din-\u0160ain", "given": "Luka", "initials": "L", "orcid": "0000-0003-3978-778X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42fed6a06cbb42b99166b05c15466483.json"}}, {"family": "Hust", "given": "Michael", "initials": "M", "orcid": "0000-0003-3418-6045", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0587ca1111f84a61aaf8917a123d49c1.json"}}], "type": "journal article", "published": "2022-03-03", "journal": {"title": "BMC Med", "issn": "1741-7015", "issn-l": null, "volume": "20", "issue": "1", "pages": "102"}, "abstract": "The COVID-19 pandemic is caused by the betacoronavirus SARS-CoV-2. In November 2021, the Omicron variant was discovered and immediately classified as a variant of concern (VOC), since it shows substantially more mutations in the spike protein than any previous variant, especially in the receptor-binding domain (RBD). We analyzed the binding of the Omicron RBD to the human angiotensin-converting enzyme-2 receptor (ACE2) and the ability of human sera from COVID-19 patients or vaccinees in comparison to Wuhan, Beta, or Delta RBD variants.\r\n\r\nAll RBDs were produced in insect cells. RBD binding to ACE2 was analyzed by ELISA and microscale thermophoresis (MST). Similarly, sera from 27 COVID-19 patients, 81 vaccinated individuals, and 34 booster recipients were titrated by ELISA on RBDs from the original Wuhan strain, Beta, Delta, and Omicron VOCs. In addition, the neutralization efficacy of authentic SARS-CoV-2 wild type (D614G), Delta, and Omicron by sera from 2\u00d7 or 3\u00d7 BNT162b2-vaccinated persons was analyzed.\r\n\r\nSurprisingly, the Omicron RBD showed a somewhat weaker binding to ACE2 compared to Beta and Delta, arguing that improved ACE2 binding is not a likely driver of Omicron evolution. Serum antibody titers were significantly lower against Omicron RBD compared to the original Wuhan strain. A 2.6\u00d7 reduction in Omicron RBD binding was observed for serum of 2\u00d7 BNT162b2-vaccinated persons. Neutralization of Omicron SARS-CoV-2 was completely diminished in our setup.\r\n\r\nThese results indicate an immune escape focused on neutralizing antibodies. Nevertheless, a boost vaccination increased the level of anti-RBD antibodies against Omicron, and neutralization of authentic Omicron SARS-CoV-2 was at least partially restored. This study adds evidence that current vaccination protocols may be less efficient against the Omicron variant.", "doi": "10.1186/s12916-022-02312-5", "pmid": "35236358", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Category: Omicron VoC": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12916-022-02312-5"}], "notes": [], "created": "2022-01-04T15:39:53.792Z", "modified": "2022-03-04T06:16:50.719Z"}, {"entity": "publication", "iuid": "7703dbb65d114688adfed1a169a34cc0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7703dbb65d114688adfed1a169a34cc0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7703dbb65d114688adfed1a169a34cc0"}}, "title": "High seroconversion rate after vaccination with mRNA BNT162b2 vaccine against SARS-CoV-2 among people with HIV - but HIV viremia matters?", "authors": [{"family": "Xu", "given": "Xinling", "initials": "X"}, {"family": "Vesterbacka", "given": "Jan", "initials": "J"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "COVAXID Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-03-01", "journal": {"title": "AIDS", "issn": "1473-5571", "volume": "36", "issue": "3", "pages": "479-481", "issn-l": null}, "abstract": "Our clinical trial of SARS-COV-2 mRNA vaccine in 90 HIV-infected persons on antiviral treatment demonstrated high seroconversion rate and high levels of spike IgG antibodies after two doses of vaccine. The vaccine was well tolerated and not associated with HIV RNA blips. However, the levels of spike IgG antibodies were lower in HIV patients than in healthy controls, especially among those with HIV RNA more than 50 copies/ml at baseline.", "doi": "10.1097/QAD.0000000000003135", "pmid": "35084386", "labels": {"Category: Health": null, "Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "00002030-202203010-00018"}], "notes": [], "created": "2022-01-31T11:46:52.414Z", "modified": "2022-01-31T11:47:42.552Z"}, {"entity": "publication", "iuid": "e2868a3088b7488ba58a50adb64fc094", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2868a3088b7488ba58a50adb64fc094.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2868a3088b7488ba58a50adb64fc094"}}, "title": "Coping with COVID: risk and resilience factors for mental health in a German representative panel study.", "authors": [{"family": "Riepenhausen", "given": "Antje", "initials": "A", "orcid": "0000-0001-8749-5349", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b96a93d2ea914a52bbcad45210d9dec7.json"}}, {"family": "Veer", "given": "Ilya M", "initials": "IM"}, {"family": "Wackerhagen", "given": "Carolin", "initials": "C"}, {"family": "Reppmann", "given": "Zala C", "initials": "ZC"}, {"family": "K\u00f6ber", "given": "G\u00f6ran", "initials": "G"}, {"family": "Ayuso-Mateos", "given": "Jos\u00e9 Luis", "initials": "JL"}, {"family": "B\u00f6gemann", "given": "Sophie A", "initials": "SA"}, {"family": "Corrao", "given": "Giovanni", "initials": "G"}, {"family": "Felez-Nobrega", "given": "Mireia", "initials": "M"}, {"family": "Abad", "given": "Josep Maria Haro", "initials": "JMH"}, {"family": "Hermans", "given": "Erno", "initials": "E"}, {"family": "van Leeuwen", "given": "Judith", "initials": "J"}, {"family": "Lieb", "given": "Klaus", "initials": "K"}, {"family": "Lorant", "given": "Vincent", "initials": "V"}, {"family": "Mary-Krause", "given": "Murielle", "initials": "M"}, {"family": "Mediavilla", "given": "Roberto", "initials": "R"}, {"family": "Melchior", "given": "Maria", "initials": "M"}, {"family": "Mittendorfer-Rutz", "given": "Ellenor", "initials": "E"}, {"family": "Compagnoni", "given": "Matteo Monzio", "initials": "MM", "orcid": "0000-0002-2105-4572", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8008fcd69074d3fa6689539c259716f.json"}}, {"family": "Pan", "given": "Kuan-Yu", "initials": "KY"}, {"family": "Puhlmann", "given": "Lara", "initials": "L"}, {"family": "Roelofs", "given": "Karin", "initials": "K"}, {"family": "Sijbrandij", "given": "Marit", "initials": "M"}, {"family": "Smith", "given": "Pierre", "initials": "P"}, {"family": "T\u00fcscher", "given": "Oliver", "initials": "O"}, {"family": "Witteveen", "given": "Anke", "initials": "A"}, {"family": "Zerban", "given": "Matthias", "initials": "M"}, {"family": "Kalisch", "given": "Raffael", "initials": "R"}, {"family": "Kr\u00f6ger", "given": "Hannes", "initials": "H"}, {"family": "Walter", "given": "Henrik", "initials": "H"}], "type": "journal article", "published": "2022-03-01", "journal": {"title": "Psychol Med", "issn": "1469-8978", "pages": "1-11", "issn-l": "0033-2917"}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic might affect mental health. Data from population-representative panel surveys with multiple waves including pre-COVID data investigating risk and protective factors are still rare.\n\nIn a stratified random sample of the German household population (n = 6684), we conducted survey-weighted multiple linear regressions to determine the association of various psychological risk and protective factors assessed between 2015 and 2020 with changes in psychological distress [(PD; measured via Patient Health Questionnaire for Depression and Anxiety (PHQ-4)] from pre-pandemic (average of 2016 and 2019) to peri-pandemic (both 2020 and 2021) time points. Control analyses on PD change between two pre-pandemic time points (2016 and 2019) were conducted. Regularized regressions were computed to inform on which factors were statistically most influential in the multicollinear setting.\n\nPHQ-4 scores in 2020 (M = 2.45) and 2021 (M = 2.21) were elevated compared to 2019 (M = 1.79). Several risk factors (catastrophizing, neuroticism, and asking for instrumental support) and protective factors (perceived stress recovery, positive reappraisal, and optimism) were identified for the peri-pandemic outcomes. Control analyses revealed that in pre-pandemic times, neuroticism and optimism were predominantly related to PD changes. Regularized regression mostly confirmed the results and highlighted perceived stress recovery as most consistent influential protective factor across peri-pandemic outcomes.\n\nWe identified several psychological risk and protective factors related to PD outcomes during the COVID-19 pandemic. A comparison of pre-pandemic data stresses the relevance of longitudinal assessments to potentially reconcile contradictory findings. Implications and suggestions for targeted prevention and intervention programs during highly stressful times such as pandemics are discussed.", "doi": "10.1017/S0033291722000563", "pmid": "35301966", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0033291722000563"}, {"db": "pmc", "key": "PMC8943230"}], "notes": [], "created": "2022-04-04T07:20:45.813Z", "modified": "2022-04-04T07:20:45.905Z"}, {"entity": "publication", "iuid": "e9b0e6c430d542bdabbe5cdf483f005b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e9b0e6c430d542bdabbe5cdf483f005b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e9b0e6c430d542bdabbe5cdf483f005b"}}, "title": "Trends in alcohol consumption in relation to the COVID-19 pandemic: A cross-country analysis.", "authors": [{"family": "Plata", "given": "Alejandro", "initials": "A"}, {"family": "Motoki", "given": "Kosuke", "initials": "K"}, {"family": "Spence", "given": "Charles", "initials": "C"}, {"family": "Velasco", "given": "Carlos", "initials": "C"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Int J Gastron Food Sci", "issn": "1878-4518", "volume": "27", "pages": "100397", "issn-l": null}, "abstract": "During the first sequence of lockdowns implemented in many countries around the world in early 2020 as a result of the emerging COVID-19 pandemic, there was widespread concern amongst many health professionals regarding a predicted rise in alcohol consumption. However, studies have reported diverse findings, with some consumer groups exhibiting an increase and others a decrease in their alcohol purchase and consumption patterns. Although the long-lasting changes in alcohol consumption, if any, are still unknown, the current situation has effectively accelerated a number of pre-existing trends which will likely continue in the future. E-commerce is growing steadily, mainly because of the restrictions within the on-trade channel and concerns around catching COVID-19 amongst consumers, thus lifting traditional barriers to the adoption of digital channels. Premiumization has also grown significantly during the pandemic, especially in the spirits category, due, in part, to the fact that consumers have been increasingly trying to recreate bar and restaurant quality gastronomic experiences in the privacy of their own homes. The trend toward homemade experiences is multi-stakeholder as consumers, retailers, restaurateurs, bar owners, and brands all try to help facilitate at-home consumption experiences. Larger size purchases seem to reflect not only the stockpiling phenomena that occurred during the initial phases of the pandemic but also convenience for consumers (e.g., avoiding queues). Additionally, the growing home mixology movement has been observed to result in consumers buying larger amounts of alcohol in order to facilitate cocktail making experimentation at home. It is important to stress, though, that this review was specially focused on available data from the first three quarters of 2020, as an effort to identify and understand the initial impacts the COVID-19 was creating amongst alcohol consumers. It currently remains uncertain how these trends will evolve, and whether or not they will continue post COVID-19 (whenever that might be). Key similarities and differences across national markets are highlighted.", "doi": "10.1016/j.ijgfs.2021.100397", "pmid": "35003399", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1878-450X(21)00096-2"}, {"db": "pmc", "key": "PMC8717736"}], "notes": [], "created": "2022-01-13T21:10:53.363Z", "modified": "2022-01-13T21:10:53.401Z"}, {"entity": "publication", "iuid": "f15625c5aebb43d8951a7f1554f20ca1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f15625c5aebb43d8951a7f1554f20ca1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f15625c5aebb43d8951a7f1554f20ca1"}}, "title": "To vote, or not to vote? Electoral campaigns and the spread of COVID-19.", "authors": [{"family": "Cipullo", "given": "Davide", "initials": "D"}, {"family": "Le Moglie", "given": "Marco", "initials": "M"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Eur J Polit Econ", "issn": "0176-2680", "issn-l": null, "volume": "72", "issue": null, "pages": "102118"}, "abstract": "The possibility to run fair electoral campaigns is necessary for the legitimization of modern democracies through elections. Yet, during a pandemic, the risk that electoral campaigns would enhance the spread of the disease is substantive. In this paper, we estimate the causal impact of electoral campaigns on the spread of COVID-19. Exploiting plausibly exogenous variation in the schedule of local elections across Italy, we show that the electoral campaign preceding this latter led to a significant worsening of the epidemiological situation related to the disease. Our results strongly highlight the importance of undertaking stringent measures along the entire electoral process to minimize its epidemiological consequences.", "doi": "10.1016/j.ejpoleco.2021.102118", "pmid": "35317430", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0176-2680(21)00100-2"}, {"db": "pmc", "key": "PMC8931692"}], "notes": [], "created": "2022-04-04T07:10:49.639Z", "modified": "2022-11-22T05:39:27.695Z"}, {"entity": "publication", "iuid": "6dcc84c5565f4f16bc811dc31d81cb4b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6dcc84c5565f4f16bc811dc31d81cb4b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6dcc84c5565f4f16bc811dc31d81cb4b"}}, "title": "The impact of the COVID-19 pandemic on seafarers' mental health and chronic fatigue: Beneficial effects of onboard peer support, external support and Internet access.", "authors": [{"family": "Pauksztat", "given": "Birgit", "initials": "B"}, {"family": "Grech", "given": "Michelle R", "initials": "MR"}, {"family": "Kitada", "given": "Momoko", "initials": "M"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Mar Policy", "issn": "0308-597X", "volume": "137", "pages": "104942", "issn-l": null}, "abstract": "While commercial shipping remained vital for maintaining global supply chains during the COVID-19 pandemic, measures imposed to control the spread of infection have disrupted crew changes and impacted interactions with port personnel and among crew members on board. Initial reports indicate that this affected work and life on board, the length of seafarers' time on board as well as seafarers' employment and family concerns. However, the consequences for seafarers' well-being are not well understood. The purpose of this study was to examine the effects of the COVID-19 pandemic on seafarers' mental health and chronic fatigue, and to analyze the role of potential mitigating factors, notably onboard peer support, external support and Internet quality. Survey responses from 622 seafarers on international commercial vessels were analyzed using structural equation modeling. Findings suggested that the impact of the pandemic increased seafarers' fatigue and mental health problems. However, they also indicated ways of mitigating the negative impact of the pandemic and increasing resilience by enhancing support from fellow crew members on board, ensuring the availability of external support and providing fast and reliable Internet access.", "doi": "10.1016/j.marpol.2021.104942", "pmid": "35013636", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0308-597X(21)00553-4"}, {"db": "pmc", "key": "PMC8732879"}], "notes": [], "created": "2022-01-13T21:04:46.083Z", "modified": "2022-01-13T21:04:46.121Z"}, {"entity": "publication", "iuid": "29f0d487451f4f468291855f641a3944", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/29f0d487451f4f468291855f641a3944.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/29f0d487451f4f468291855f641a3944"}}, "title": "Risk of severe COVID-19 from the Delta and Omicron variants in relation to vaccination status, sex, age and comorbidities - surveillance results from southern Sweden, July 2021 to January 2022.", "authors": [{"family": "Kahn", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-5566-6350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42eda71f3775400599febc10a4e7359c.json"}}, {"family": "Bonander", "given": "Carl", "initials": "C", "orcid": "0000-0002-1189-9950", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/386ac82b1a4843828b503ec807c08206.json"}}, {"family": "Moghaddassi", "given": "Mahnaz", "initials": "M", "orcid": "0000-0002-0844-4736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a219bde5ba8a4f3f8655ada08d749885.json"}}, {"family": "Rasmussen", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1588-5473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c760e8d21ae441ba236f86e6185d392.json"}}, {"family": "Malmqvist", "given": "Ulf", "initials": "U"}, {"family": "Inghammar", "given": "Malin", "initials": "M", "orcid": "0000-0003-2995-1312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4ab710428614cccb2a537ecab31d0a0.json"}}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J", "orcid": "0000-0003-1883-2000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e88fdca336ae41c891f0a46e2481b67f.json"}}], "type": "journal article", "published": "2022-03-00", "journal": {"issn": "1560-7917", "volume": "27", "issue": "9", "title": "Euro Surveill", "issn-l": null}, "abstract": "We compared the risk of severe COVID-19 during two periods 2021 and 2022 when Delta and Omicron, respectively, were the dominating virus variants in Scania county, Sweden. We adjusted for differences in sex, age, comorbidities, prior infection and vaccination. Risk of severe disease from Omicron was markedly lower among vaccinated cases. It was also lower among the unvaccinated but remained high (> 5%) for older people and middle-aged men with two or more comorbidities. Efforts to increase vaccination uptake should continue.", "doi": "10.2807/1560-7917.ES.2022.27.9.2200121", "pmid": "35241215", "labels": {"Category: Health": null, "Category: Omicron VoC": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8895467"}], "notes": [], "created": "2022-03-04T12:16:55.501Z", "modified": "2023-01-13T13:29:15.838Z"}, {"entity": "publication", "iuid": "ced6307812f3447f90283e6d7a76ed1b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ced6307812f3447f90283e6d7a76ed1b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ced6307812f3447f90283e6d7a76ed1b"}}, "title": "Risk factors associated with an outbreak of COVID-19 in a meat processing plant in southern Germany, April to June 2020.", "authors": [{"family": "Finci", "given": "Iris", "initials": "I"}, {"family": "Siebenbaum", "given": "Remo", "initials": "R"}, {"family": "Richtzenhain", "given": "Josephin", "initials": "J"}, {"family": "Edwards", "given": "Angelika", "initials": "A"}, {"family": "Rau", "given": "Carina", "initials": "C"}, {"family": "Ehrhardt", "given": "Jonas", "initials": "J"}, {"family": "Koiou", "given": "Linda", "initials": "L"}, {"family": "Joggerst", "given": "Brigitte", "initials": "B"}, {"family": "Brockmann", "given": "Stefan O", "initials": "SO"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "27", "issue": "13", "issn-l": null}, "abstract": "Meat processing plants have been prominent hotspots for coronavirus disease (COVID-19) outbreaks around the world. We describe infection prevention measures and risk factors for infection spread at a meat processing plant in Germany with a COVID-19 outbreak from April to June 2020. We analysed a cohort of all employees and defined cases as employees with either a PCR or ELISA positive result. Of 1,270 employees, 453 (36%) had evidence of SARS-CoV-2 infection. The highest attack rates were observed in meat processing and slaughtering areas. Multivariable analysis revealed that being a subcontracted employee (adjusted risk ratio (aRR)): 1.43, 95% CI: 1.06-1.96), working in the meat cutting area (aRR: 2.44, 95% CI: 1.45-4.48), working in the slaughtering area (aRR: 2.35, 95% CI: 1.32-4.45) and being a veterinary inspector (aRR: 4.77, 95% CI: 1.16-23.68) increased infection risk. Sharing accommodation or transportation were not identified as risk factors for infection. Our results suggest that workplace was the main risk factor for infection spread. These results highlight the importance of implementing preventive measures targeting meat processing plants. Face masks, distancing, staggering breaks, increased hygiene and regular testing for SARS-CoV2 helped limit this outbreak, as the plant remained open throughout the outbreak.", "doi": "10.2807/1560-7917.ES.2022.27.13.2100354", "pmid": "35362409", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-04-04T06:26:04.791Z", "modified": "2022-04-04T06:32:06.397Z"}, {"entity": "publication", "iuid": "fbc972343a6d4cd5a996f6174fb380bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fbc972343a6d4cd5a996f6174fb380bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fbc972343a6d4cd5a996f6174fb380bf"}}, "title": "Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19.", "authors": [{"family": "Palmos", "given": "Alish B", "initials": "AB", "orcid": "0000-0001-5748-6652", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dcc29f88bdd44f679b0627ecde4b1369.json"}}, {"family": "Millischer", "given": "Vincent", "initials": "V", "orcid": "0000-0003-1919-9649", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fc3992e3cd045169e4b45e55e621071.json"}}, {"family": "Menon", "given": "David K", "initials": "DK", "orcid": "0000-0002-3228-9692", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a9033d3171140c696fcb18b9983ac2e.json"}}, {"family": "Nicholson", "given": "Timothy R", "initials": "TR", "orcid": "0000-0002-2350-2332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bd53b4c7f1a4b2a853fcefc53184111.json"}}, {"family": "Taams", "given": "Leonie S", "initials": "LS"}, {"family": "Michael", "given": "Benedict", "initials": "B", "orcid": "0000-0002-8693-8926", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d0bd491219e64319aef1794f6ae1761e.json"}}, {"family": "Sunderland", "given": "Geraint", "initials": "G", "orcid": "0000-0001-9040-5949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6fcce9323d74d719807117806217c46.json"}}, {"family": "Griffiths", "given": "Michael J", "initials": "MJ"}, {"family": "COVID Clinical Neuroscience Study Consortium", "given": "", "initials": ""}, {"family": "H\u00fcbel", "given": "Christopher", "initials": "C"}, {"family": "Breen", "given": "Gerome", "initials": "G"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "PLoS Genet", "issn": "1553-7404", "volume": "18", "issue": "3", "pages": "e1010042", "issn-l": null}, "abstract": "In November 2021, the COVID-19 pandemic death toll surpassed five million individuals. We applied Mendelian randomization including >3,000 blood proteins as exposures to identify potential biomarkers that may indicate risk for hospitalization or need for respiratory support or death due to COVID-19, respectively. After multiple testing correction, using genetic instruments and under the assumptions of Mendelian Randomization, our results were consistent with higher blood levels of five proteins GCNT4, CD207, RAB14, C1GALT1C1, and ABO being causally associated with an increased risk of hospitalization or respiratory support/death due to COVID-19 (ORs = 1.12-1.35). Higher levels of FAAH2 were solely associated with an increased risk of hospitalization (OR = 1.19). On the contrary, higher levels of SELL, SELE, and PECAM-1 decrease risk of hospitalization or need for respiratory support/death (ORs = 0.80-0.91). Higher levels of LCTL, SFTPD, KEL, and ATP2A3 were solely associated with a decreased risk of hospitalization (ORs = 0.86-0.93), whilst higher levels of ICAM-1 were solely associated with a decreased risk of respiratory support/death of COVID-19 (OR = 0.84). Our findings implicate blood group markers and binding proteins in both hospitalization and need for respiratory support/death. They, additionally, suggest that higher levels of endocannabinoid enzymes may increase the risk of hospitalization. Our research replicates findings of blood markers previously associated with COVID-19 and prioritises additional blood markers for risk prediction of severe forms of COVID-19. Furthermore, we pinpoint druggable targets potentially implicated in disease pathology.", "doi": "10.1371/journal.pgen.1010042", "pmid": "35239653", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "PGENETICS-D-21-01126"}], "notes": [], "created": "2022-03-04T06:17:49.932Z", "modified": "2022-03-04T06:18:03.322Z"}, {"entity": "publication", "iuid": "e4fb546c8a6f42708ca685bfc253704a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e4fb546c8a6f42708ca685bfc253704a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e4fb546c8a6f42708ca685bfc253704a"}}, "title": "Nowcasting (Short-Term Forecasting) of COVID-19 Hospitalizations Using Syndromic Healthcare Data, Sweden, 2020.", "authors": [{"family": "Spreco", "given": "Armin", "initials": "A"}, {"family": "J\u00f6ud", "given": "Anna", "initials": "A", "orcid": "0000-0001-7192-4911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e038a5ce2f5a47bd89e7c221651a3d24.json"}}, {"family": "Eriksson", "given": "Olle", "initials": "O"}, {"family": "Soltesz", "given": "Kristian", "initials": "K"}, {"family": "K\u00e4llstr\u00f6m", "given": "Reidar", "initials": "R"}, {"family": "Dahlstr\u00f6m", "given": "\u00d6rjan", "initials": "\u00d6"}, {"family": "Eriksson", "given": "Henrik", "initials": "H"}, {"family": "Ekberg", "given": "Joakim", "initials": "J"}, {"family": "Jonson", "given": "Carl-Oscar", "initials": "CO"}, {"family": "Fraenkel", "given": "Carl-Johan", "initials": "CJ"}, {"family": "Lundh", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Gerlee", "given": "Philip", "initials": "P", "orcid": "0000-0001-8503-0177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ba426c1ab741e781d2b9cd09a0b830.json"}}, {"family": "Gustafsson", "given": "Fredrik", "initials": "F"}, {"family": "Timpka", "given": "Toomas", "initials": "T"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Emerg Infect Dis", "issn": "1080-6059", "volume": "28", "issue": "3", "pages": "564-571", "issn-l": null}, "abstract": "We report on local nowcasting (short-term forecasting) of coronavirus disease (COVID-19) hospitalizations based on syndromic (symptom) data recorded in regular healthcare routines in \u00d6sterg\u00f6tland County (population \u2248465,000), Sweden, early in the pandemic, when broad laboratory testing was unavailable. Daily nowcasts were supplied to the local healthcare management based on analyses of the time lag between telenursing calls with the chief complaints (cough by adult or fever by adult) and COVID-19 hospitalization. The complaint cough by adult showed satisfactory performance (Pearson correlation coefficient r>0.80; mean absolute percentage error <20%) in nowcasting the incidence of daily COVID-19 hospitalizations 14 days in advance until the incidence decreased to <1.5/100,000 population, whereas the corresponding performance for fever by adult was unsatisfactory. Our results support local nowcasting of hospitalizations on the basis of symptom data recorded in routine healthcare during the initial stage of a pandemic.", "doi": "10.3201/eid2803.210267", "pmid": "35201737", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8888224"}], "notes": [], "created": "2023-01-13T13:40:49.234Z", "modified": "2023-06-19T14:58:56.435Z"}, {"entity": "publication", "iuid": "6dff0f71c8d54791be1886456cb3fcd2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6dff0f71c8d54791be1886456cb3fcd2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6dff0f71c8d54791be1886456cb3fcd2"}}, "title": "Inequitable impact of infection: social gradients in severe COVID-19 outcomes among all confirmed SARS-CoV-2 cases during the first pandemic wave in Sweden.", "authors": [{"family": "Gustafsson", "given": "Per E", "initials": "PE", "orcid": "0000-0002-3972-5362", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9ac282ae534432f9e8135a8070683bc.json"}}, {"family": "San Sebastian", "given": "Miguel", "initials": "M"}, {"family": "Fonseca-Rodriguez", "given": "Osvaldo", "initials": "O", "orcid": "0000-0002-0253-5928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52ff35d4b27c4150984ca0428976d442.json"}}, {"family": "Fors Connolly", "given": "Anne-Marie", "initials": "AM"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "J Epidemiol Community Health", "issn": "1470-2738", "issn-l": null, "volume": "76", "issue": "3", "pages": "261-267"}, "abstract": "The backdrop of the ubiquitous social inequalities has increasingly come into foreground in research on the COVID-19 pandemic, but the lack of high-quality population-based studies limits our understanding of the inequitable outcomes of the disease. The present study seeks to estimate social gradients in COVID-19 hospitalisations, intensive care admissions and death by education, income and country of birth, while taking into account disparities in comorbidities.\n\nWe used a register-based retrospective open cohort design enrolling all 74 659 confirmed SARS-CoV-2-positive cases aged >25 years in Sweden during the first wave of the pandemic (until 14 September 2020). Information was retrieved from multiple registers and linked by the unique Swedish personal identity number concerning COVID-19 case identification; COVID-19 hospitalisations, intensive care admissions and death; comorbidities as measured by the Charlson Comorbidity Index; and sociodemographic information. Social gradients were estimated by the Relative Index of Inequality (RII) using Cox regression.\n\nAdjusted analyses showed significant social gradients in COVID-19 hospitalisation, intensive care admission, across education, income and country of birth, which were unaffected by adjustment for comorbidities. Education and country of birth gradients were stronger for hospitalisation and intensive care admissions but small to non-existent for death. In contrast, income gradients were consistent across all three COVID-19 outcomes.\n\nSocial gradients in severe COVID-19 outcomes are widespread in Sweden, but appear to be unrelated to pre-existing health disparities. Inequitable outcomes of SARS-CoV-2 infection may therefore be at least partially avoidable and could rely on equitable management of confirmed COVID-19 cases.", "doi": "10.1136/jech-2021-216778", "pmid": "34526373", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8449839"}, {"db": "pii", "key": "jech-2021-216778"}], "notes": [], "created": "2021-09-20T16:49:45.287Z", "modified": "2023-01-13T13:54:20.184Z"}, {"entity": "publication", "iuid": "54b72a2f5d5d4388bf593a0fbc1bbaa5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54b72a2f5d5d4388bf593a0fbc1bbaa5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54b72a2f5d5d4388bf593a0fbc1bbaa5"}}, "title": "Impact of COVID-19 on adolescent travel behavior.", "authors": [{"family": "Liu", "given": "Jianrong", "initials": "J"}, {"family": "Cao", "given": "Qiongwen", "initials": "Q"}, {"family": "Pei", "given": "Mingyang", "initials": "M"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "J Transp Health", "issn": "2214-1405", "volume": "24", "pages": "101326", "issn-l": null}, "abstract": "The outbreak of COVID-19 has significantly impacted travel behavior. However, few studies have analyzed the impact of COVID-19 on adolescent travel behavior. This article analyzed the impact of COVID-19 on adolescent travel behavior using questionnaire survey data.\n\nThis paper first used confirmatory factor analysis (CFA) to explore the psychological factors related to the adolescents' perceptions about the severity of COVID-19. The study then established a logit model to study the effects of COVID-19 in different phases (before, during, and after the epidemic peak), demographic characteristics, and the role of psychological factors on their travel behavior.\n\nThe results show that the phase of COVID-19 did not significantly impact the adolescents' choice of short-distance travel. The frequency of outings per week, the number of exercise sessions per week, and willingness to travel by public transportation decreased significantly in the outbreak phase. Meanwhile, the perception of the severity of COVID-19 significantly impacted adolescent travel behavior.\n\nThis research demonstrates that COVID-19 has led adolescents to reduce their frequency of outings, and they try not to use public transportation. Adolescents appear to be traveling more cautiously in the outbreak phase and the post-epidemic phase.", "doi": "10.1016/j.jth.2021.101326", "pmid": "35013706", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2214-1405(21)00356-X"}, {"db": "pmc", "key": "PMC8730543"}], "notes": [], "created": "2022-01-13T21:04:28.715Z", "modified": "2022-01-13T21:04:28.749Z"}, {"entity": "publication", "iuid": "69ee238aa92f414db1e2f921762e76eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69ee238aa92f414db1e2f921762e76eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69ee238aa92f414db1e2f921762e76eb"}}, "title": "Ethics framework and recommendations to support capabilities of people with intellectual and developmental disabilities during pandemics.", "authors": [{"family": "Sullivan", "given": "William F", "initials": "WF", "orcid": "0000-0002-0520-0541", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e747cb9cd7f3443e8ef4432fc6204ca2.json"}}, {"family": "Bj\u00f6rne", "given": "Petra", "initials": "P", "orcid": "0000-0001-8085-2008", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/226848f597ca496cacf85b62ba73886c.json"}}, {"family": "Heng", "given": "John", "initials": "J", "orcid": "0000-0002-6080-580X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a04c6d3b0274883b6221f74dfd88eb9.json"}}, {"family": "Northway", "given": "Ruth", "initials": "R"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "J Policy Pract Intellect Disabil", "issn": "1741-1122", "volume": "19", "issue": "1", "pages": "116-124", "issn-l": null}, "abstract": "A growing body of knowledge highlights the negative impact of the COVID-19 pandemic on the health and well-being of many people with intellectual and developmental disabilities (IDDs) and their caregivers. The underlying reasons are not only due to biomedical factors but also ethical issues. They stem from longstanding and pervasive structural injustices and negative social attitudes that continue to devalue people with IDD and that underlie certain clinical decisions and frameworks for public-health policies during this pandemic. Unless these fundamental ethical shortcomings are addressed, pandemic responses will continue to undermine the human rights and well-being of people with IDD. This paper proposes an ethics framing for policy and practices regarding clinical care and public health based on Martha Nussbaum's approach to Capability Theory. Such a framework can reorient healthcare professionals and healthcare systems to support the capabilities of people with IDD to protect, recover, and promote health and well-being. It could be applied during this pandemic and in planning for future pandemics. The paper presents some practical recommendations that follow from applying this framework.", "doi": "10.1111/jppi.12413", "pmid": "35601010", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "JPPI12413"}, {"db": "pmc", "key": "PMC9115164"}], "notes": [], "created": "2022-06-21T17:56:57.068Z", "modified": "2022-06-21T17:56:57.217Z"}, {"entity": "publication", "iuid": "639c6314592045dbbc3fb5b75de89134", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/639c6314592045dbbc3fb5b75de89134.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/639c6314592045dbbc3fb5b75de89134"}}, "title": "Detection and isolation of airborne SARS-CoV-2 in a hospital setting.", "authors": [{"family": "Rufino de Sousa", "given": "Nuno", "initials": "N", "orcid": "0000-0002-0670-9788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1cb037a9e7f44a489dd84d6f5ba513d7.json"}}, {"family": "Steponaviciute", "given": "Laura", "initials": "L"}, {"family": "Margerie", "given": "Lucille", "initials": "L", "orcid": "0000-0001-9537-1231", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e7015e5251242ecb70df112f997182b.json"}}, {"family": "Nissen", "given": "Karolina", "initials": "K"}, {"family": "Kjellin", "given": "Midori", "initials": "M", "orcid": "0000-0002-1377-6014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cbf761ec44641a5a70ee1b8f7964a20.json"}}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Salaneck", "given": "Erik", "initials": "E"}, {"family": "Udekwu", "given": "Klas I", "initials": "KI"}, {"family": "Rothfuchs", "given": "Antonio Gigliotti", "initials": "AG", "orcid": "0000-0001-6001-7240", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00102c49ae2d41828272e850cd551c9f.json"}}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Indoor Air", "issn": "0905-6947", "volume": "32", "issue": "3", "pages": "e13023", "issn-l": null}, "abstract": "Transmission mechanisms for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are incompletely understood. In particular, aerosol transmission remains unclear, with viral detection in air and demonstration of its infection potential being actively investigated. To this end, we employed a novel electrostatic collector to sample air from rooms occupied by COVID-19 patients in a major Swedish hospital. Electrostatic air sampling in conjunction with extraction-free, reverse-transcriptase polymerase chain reaction (hid-RT-PCR) enabled detection of SARS-CoV-2 in air from patient rooms (9/22; 41%) and adjoining anterooms (10/22; 45%). Detection with hid-RT-PCR was concomitant with viral RNA presence on the surface of exhaust ventilation channels in patients and anterooms more than 2 m from the COVID-19 patient. Importantly, it was possible to detect active SARS-CoV-2 particles from room air, with a total of 496 plaque-forming units (PFUs) being isolated, establishing the presence of infectious, airborne SARS-CoV-2 in rooms occupied by COVID-19 patients. Our results support circulation of SARS-CoV-2 via aerosols and urge the revision of existing infection control frameworks to include airborne transmission.", "doi": "10.1111/ina.13023", "pmid": "35347788", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null, "Research Area: Pandemic preparedness": null, "Funder: KAW/SciLifeLab": null, "Category: Other": null, "Research Area: Diagnostics for virus": null}, "xrefs": [], "notes": [], "created": "2022-03-29T15:54:03.910Z", "modified": "2022-04-04T06:43:36.321Z"}, {"entity": "publication", "iuid": "53b1f06a77394293a23a2f053f38c850", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53b1f06a77394293a23a2f053f38c850.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53b1f06a77394293a23a2f053f38c850"}}, "title": "Consultations with health care providers and use of self-management strategies for prevention and treatment of COVID-19 related symptoms. A population based cross-sectional study in Norway, Sweden and the Netherlands.", "authors": [{"family": "Kristoffersen", "given": "Agnete E", "initials": "AE"}, {"family": "van der Werf", "given": "Esther T", "initials": "ET"}, {"family": "Stub", "given": "Trine", "initials": "T"}, {"family": "Musial", "given": "Frauke", "initials": "F"}, {"family": "Wider", "given": "Barbara", "initials": "B"}, {"family": "Jong", "given": "Miek C", "initials": "MC"}, {"family": "Wode", "given": "Kathrin", "initials": "K"}, {"family": "Danell", "given": "Jenny-Ann B", "initials": "JB"}, {"family": "Busch", "given": "Martine", "initials": "M"}, {"family": "Hoenders", "given": "H J Rogier", "initials": "HJR"}, {"family": "Nordberg", "given": "Johanna H", "initials": "JH"}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Complement Ther Med", "issn": "1873-6963", "volume": "64", "pages": "102792", "issn-l": null}, "abstract": "The present study was initiated to determine consultations with health care providers and use of self-management strategies for prevention or treatment of COVID-19 related symptoms in countries with a full lockdown (Norway), a partial lockdown (the Netherlands) and no lockdown (Sweden) during the first three months of the COVID-19 pandemic, and if such use correlates with worries of being infected by COVID-19 disease.\n\nData were collected in collaboration with Ipsos A/S in April-June 2020. An adapted version of the International Questionnaire to measure use of Complementary and Alternative Medicine (I-CAM-Q) was used with the categories \"for prevention of COVID-19\" and \"to treat COVID-19-related symptoms\" added. Data were collected among a representative sample in Norway, Sweden and the Netherlands using data assisted telephone interviews (Norway, n=990 and Sweden, n=500), and an online survey (the Netherlands, n=1004). Total response rate was 30%.\n\nVery few consulted a health care provider with the intention to treat or prevent COVID-19 (1.2% and 1.0% respectively) with medical doctors mostly visited (1.0% and 0.9% respectively). Similarly, the use of self-management strategies to prevent or treat COVID-19 was low (3.4% and 0.2% respectively); most commonly used for prevention of COVID-19 were vitamins and minerals (2.8%). Consultations with health care providers and use of self-management strategies for prevention of COVID-19 were positively associated with worries of being infected with COVID-19.\n\nThe COVID-19 pandemic does not seem to have evoked a large-scale difference in behavior related to consultations with health care providers or the use of self-management strategies in any of the three countries.", "doi": "10.1016/j.ctim.2021.102792", "pmid": "34826590", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8609665"}, {"db": "pii", "key": "S0965-2299(21)00133-3"}], "notes": [], "created": "2021-12-18T18:18:07.845Z", "modified": "2023-01-13T13:50:24.202Z"}, {"entity": "publication", "iuid": "611e7570be744b3e9fcc1ac31c571e7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/611e7570be744b3e9fcc1ac31c571e7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/611e7570be744b3e9fcc1ac31c571e7e"}}, "title": "In-Flight Transmission of a SARS-CoV-2 Lineage B.1.617.2 Harbouring the Rare S:E484Q Immune Escape Mutation.", "authors": [{"family": "Martinell", "given": "Mats", "initials": "M"}, {"family": "Andersson", "given": "Tanja", "initials": "T"}, {"family": "Mannsverk", "given": "Steinar Sm\u00f8rholm", "initials": "SS"}, {"family": "Bergholm", "given": "Julia", "initials": "J"}, {"family": "Ellstr\u00f6m", "given": "Patrik", "initials": "P"}, {"family": "Hill", "given": "Anna", "initials": "A"}, {"family": "Lindh", "given": "Johan", "initials": "J"}, {"family": "Kaden", "given": "Rene", "initials": "R", "orcid": "0000-0002-2111-9751", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2be6374ef0bf4ba39e5f5dbbb059747f.json"}}], "type": "journal article", "published": "2022-02-28", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "3", "issn-l": "1999-4915"}, "abstract": "We describe a flight-associated infection scenario of seven individuals with a B.1.617.2 (Delta) lineage, harbouring an S:E484Q point mutation. In Sweden, at least 10% of all positive SARS-CoV-2 samples were sequenced in each county; the B.1.717.2 + S:E484Q combination was not detected in Sweden before and was imported within the scenario described in this report. The high transmission rate of the delta lineage combined with the S:E484Q mutation, associated with immune escape in other lineages, makes this specific genetic combination a possible threat to the global fight against the COVID-19 pandemic. Even within the Omicron wave, the B.1.617.2 + S:E484Q variant appeared in community samples in Sweden, as it seems that this combination has an evolutionary gain compared to other B.1.617.2 lineages. The here described genomic combination was not detectable with the common fasta file-based Pango-lineage analysis, hence increasing the probability of the true global prevalence to be higher.", "doi": "10.3390/v14030504", "pmid": "35336908", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "v14030504"}, {"db": "pmc", "key": "PMC8953675"}], "notes": [], "created": "2022-03-28T16:42:05.248Z", "modified": "2022-04-04T06:52:20.339Z"}, {"entity": "publication", "iuid": "0da027ce656c4236937fd53d3ff32362", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0da027ce656c4236937fd53d3ff32362.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0da027ce656c4236937fd53d3ff32362"}}, "title": "Short-term improvement of mental health after a COVID-19 vaccination", "authors": [{"family": "Chourpiliadis", "given": "Charilaos", "initials": "C", "orcid": "0000-0002-4733-5698", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60f9cb9172274531bc75c430eeb74a31.json"}}, {"family": "Lovik", "given": "Anik\u00f3", "initials": "A", "orcid": "0000-0002-6397-5011", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e50d5a79a1234cd79b22ec2eebf6f410.json"}}, {"family": "K\u00e4hler", "given": "Anna K", "initials": "AK", "orcid": "0000-0003-4047-4588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6d52ec01645417eb73e2bfe6c3106bd.json"}}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA", "orcid": "0000-0001-5382-946X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87d1dbec7c6f4942b1db2b999eeb9ece.json"}}, {"family": "Frans", "given": "Emma M", "initials": "EM", "orcid": "0000-0002-9791-687X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/157f412416124221ab8387bfaee3b75b.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF", "orcid": "0000-0002-6619-873X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f9632d685f348cea7a69ebfe51ad0ab.json"}}, {"family": "Fang", "given": "Fang", "initials": "F", "orcid": "0000-0002-3310-6456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b0852465cd14239a25329b976172792.json"}}], "type": "posted-content", "published": "2022-02-27", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.02.22.22271327", "pmid": null, "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Preprint": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2023-02-13T18:39:58.873Z", "modified": "2023-02-13T18:40:15.895Z"}, {"entity": "publication", "iuid": "45f65fcb21a545e79c2083314dda7609", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/45f65fcb21a545e79c2083314dda7609.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/45f65fcb21a545e79c2083314dda7609"}}, "title": "Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line.", "authors": [{"family": "Ald\u00e9n", "given": "Markus", "initials": "M", "orcid": "0000-0002-5166-0055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb334111adf44509a04451a8d3b36483.json"}}, {"family": "Olofsson Falla", "given": "Francisko", "initials": "F"}, {"family": "Yang", "given": "Daowei", "initials": "D"}, {"family": "Barghouth", "given": "Mohammad", "initials": "M"}, {"family": "Luan", "given": "Cheng", "initials": "C"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}, {"family": "De Marinis", "given": "Yang", "initials": "Y", "orcid": "0000-0002-8081-2142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c85c6f6e14a44415a2bea1cfe224e50c.json"}}], "type": "journal article", "published": "2022-02-25", "journal": {"title": "CIMB", "issn": "1467-3045", "volume": "44", "issue": "3", "pages": "1115-1126", "issn-l": null}, "abstract": "Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 injection. Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of human cells. In this study, we investigated the effect of BNT162b2 on the human liver cell line Huh7 in vitro. Huh7 cells were exposed to BNT162b2, and quantitative PCR was performed on RNA extracted from the cells. We detected high levels of BNT162b2 in Huh7 cells and changes in gene expression of long interspersed nuclear element-1 (LINE-1), which is an endogenous reverse transcriptase. Immunohistochemistry using antibody binding to LINE-1 open reading frame-1 RNA-binding protein (ORFp1) on Huh7 cells treated with BNT162b2 indicated increased nucleus distribution of LINE-1. PCR on genomic DNA of Huh7 cells exposed to BNT162b2 amplified the DNA sequence unique to BNT162b2. Our results indicate a fast up-take of BNT162b2 into human liver cell line Huh7, leading to changes in LINE-1 expression and distribution. We also show that BNT162b2 mRNA is reverse transcribed intracellularly into DNA in as fast as 6 h upon BNT162b2 exposure.", "doi": "10.3390/cimb44030073", "pmid": "35723296", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "cimb44030073"}, {"db": "pmc", "key": "PMC8946961"}], "notes": [], "created": "2022-06-20T18:01:55.926Z", "modified": "2022-08-17T12:44:56.372Z"}, {"entity": "publication", "iuid": "4df609687e91421ebc10c9fc487f13f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4df609687e91421ebc10c9fc487f13f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4df609687e91421ebc10c9fc487f13f9"}}, "title": "The impact of COVID-19 related regulations and restrictions on mobility and potential for sustained climate mitigation across the Netherlands, Sweden and the UK: a data-based commentary.", "authors": [{"family": "Corker", "given": "Elizabeth", "initials": "E", "orcid": "0000-0002-2055-7493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72e2b85d3fc048b782da99c5e92e2774.json"}}, {"family": "Mitev", "given": "Kaloyan", "initials": "K", "orcid": "0000-0001-6148-4852", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa5cfd4a1b0642948d3d3728807b025b.json"}}, {"family": "Nilsson Lewis", "given": "Astrid", "initials": "A", "orcid": "0000-0002-2090-4379", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94deaedf05ea44f695bde2bd28d091a9.json"}}, {"family": "Tamis", "given": "Milan", "initials": "M"}, {"family": "Bouman", "given": "Thijs", "initials": "T", "orcid": "0000-0001-7940-892X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98f3843dc2dd49df9b163eb18e96ba04.json"}}, {"family": "Holmlid", "given": "Stefan", "initials": "S", "orcid": "0000-0002-2529-4303", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3caccddc41004ca58051819bfcbe4c1c.json"}}, {"family": "Lambe", "given": "Fiona", "initials": "F", "orcid": "0000-0003-3664-9891", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b83be50ea2ce4109a7f62a21760c0e22.json"}}, {"family": "Michie", "given": "Susan", "initials": "S", "orcid": "0000-0003-0063-6378", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2da07e2d6bd54e6aa3d3496c8bdac4d8.json"}}, {"family": "Osborne", "given": "Matthew", "initials": "M", "orcid": "0000-0003-0272-1496", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e75a8ae678b48078261ace855732360.json"}}, {"family": "Jan Renes", "given": "Reint", "initials": "R", "orcid": "0000-0003-2448-9480", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4926b953047471e9cc46fa18e978dff.json"}}, {"family": "Steg", "given": "Linda", "initials": "L", "orcid": "0000-0002-8375-9607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87f6c790280e4a17836805c5cd9beb80.json"}}, {"family": "Whitmarsh", "given": "Lorraine", "initials": "L", "orcid": "0000-0002-9054-1040", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d350670e761467cbfe8a92f59075ab6.json"}}], "type": "journal article", "published": "2022-02-24", "journal": {"title": "UCL Open Environ", "issn": "2632-0886", "issn-l": null, "volume": "4", "issue": null, "pages": "e032"}, "abstract": "Human behaviour change is necessary to meet targets set by the Paris Agreement to mitigate climate change. Restrictions and regulations put in place globally to mitigate the spread of COVID-19 during 2020 have had a substantial impact on everyday life, including many carbon-intensive behaviours such as transportation. Changes to transportation behaviour may reduce carbon emissions. Behaviour change theory can offer perspective on the drivers and influences of behaviour and shape recommendations for how policy-makers can capitalise on any observed behaviour changes that may mitigate climate change. For this commentary, we aimed to describe changes in data relating to transportation behaviours concerning working from home during the COVID-19 pandemic across the Netherlands, Sweden and the UK. We display these identified changes in a concept map, suggesting links between the changes in behaviour and levels of carbon emissions. We consider these changes in relation to a comprehensive and easy to understand model of behaviour, the Opportunity, Motivation Behaviour (COM-B) model, to understand the capabilities, opportunities and behaviours related to the observed behaviour changes and potential policy to mitigate climate change. There is now an opportunity for policy-makers to increase the likelihood of maintaining pro-environmental behaviour changes by providing opportunities, improving capabilities and maintaining motivation for these behaviours.", "doi": "10.14324/111.444/ucloe.000032", "pmid": "37228472", "labels": {"Category: Social Science & Humanities": null, "Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC10208342"}], "notes": [], "created": "2023-10-04T05:12:20.944Z", "modified": "2023-10-04T08:15:41.184Z"}, {"entity": "publication", "iuid": "4ab647b562b74e799cbad8075838427f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ab647b562b74e799cbad8075838427f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ab647b562b74e799cbad8075838427f"}}, "title": "Duration of SARS-CoV-2 Immune Responses Up to Six Months Following Homologous or Heterologous Primary Immunization with ChAdOx1 nCoV-19 and BNT162b2 mRNA Vaccines.", "authors": [{"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f28f2f6ac9648629c2d2de92fe7bb59.json"}}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/305bca9e5c6c423898c272bf06ce2f2a.json"}}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Nilsson", "given": "Charlotta", "initials": "C"}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2022-02-24", "journal": {"title": "Vaccines", "issn": "2076-393X", "issn-l": null, "volume": "10", "issue": "3", "pages": "359"}, "abstract": "Heterologous primary immunization against SARS-CoV-2 is part of applied recommendations. However, little is known about duration of immune responses after heterologous vaccine regimens. To evaluate duration of immune responses after primary vaccination with homologous adeno-vectored ChAdOx1 nCoV-19 vaccine (ChAd) or heterologous ChAd/BNT162b2 mRNA vaccine (BNT), anti-spike-IgG and SARS-CoV-2 VOC-neutralizing antibody responses were measured in 354 healthcare workers (HCW) at 2 weeks, 3 months, 5 months and 6 months after the second vaccine dose. T-cell responses were investigated using a whole blood interferon gamma (IFN-\u03b3) release assay 2 weeks and 3 months post second vaccine dose. Two hundred and ten HCW immunized with homologous BNT were enrolled for comparison of antibody responses. In study participants na\u00efve to SARS-CoV-2 prior to vaccination, heterologous ChAd/BNT resulted in 6-fold higher peak anti-spike IgG antibody titers compared to homologous ChAd vaccination. The half-life of antibody titers was 3.1 months (95% CI 2.8-3.6) following homologous ChAd vaccination and 1.9 months (95% CI 1.7-2.1) after heterologous vaccination, reducing the GMT difference between the groups to 3-fold 6 months post vaccination. Peak T-cell responses were stronger in ChAd/BNT vaccinees, but no significant difference was observed 3 months post vaccination. SARS-CoV-2 infection prior to vaccination resulted in substantially higher peak GMTs and IFN-\u03b3 levels and enhanced SARS-CoV-2 specific antibody and T cell responses over time. Heterologous primary SARS-CoV-2 immunization with ChAd and BNT elicits a stronger initial immune response compared to homologous vaccination with ChAd. However, although the differences in humoral responses remain over 6 months, the difference in SARS-CoV-2 specific T cell responses are no longer significant three months after vaccination.", "doi": "10.3390/vaccines10030359", "pmid": "35334989", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null, "Funder: VR": null, "Research Area: Drug discovery and repurposing of drugs": null, "Research Area: High-throughput and high-content serology": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC8953845"}, {"db": "pii", "key": "vaccines10030359"}], "notes": [], "created": "2022-03-28T16:45:51.963Z", "modified": "2023-06-19T14:27:58.481Z"}, {"entity": "publication", "iuid": "248d757ee8874cc4a15d38810b8a6e3e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/248d757ee8874cc4a15d38810b8a6e3e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/248d757ee8874cc4a15d38810b8a6e3e"}}, "title": "Influence of the COVID-19 pandemic on abortions and births in Sweden: a mixed-methods study.", "authors": [{"family": "Rydelius", "given": "Johanna", "initials": "J", "orcid": "0000-0003-3480-9177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93fdadd0e5504aa9bedb5f5f8071051b.json"}}, {"family": "Edalat", "given": "Mina", "initials": "M"}, {"family": "Nyman", "given": "Viola", "initials": "V"}, {"family": "Jar-Allah", "given": "Tagrid", "initials": "T", "orcid": "0000-0002-4394-6299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a4815ddb6224ebd8e14cbaa36b7166b.json"}}, {"family": "Milsom", "given": "Ian", "initials": "I"}, {"family": "Hognert", "given": "Helena", "initials": "H"}], "type": "journal article", "published": "2022-02-23", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "2", "pages": "e054076", "issn-l": "2044-6055"}, "abstract": "Although considered an essential service by the WHO, there are indications that access to induced abortion care has been restricted during the COVID-19 pandemic.\n\nTo investigate if the number of induced abortions and ongoing pregnancies changed during the first pandemic wave of COVID-19 in 2020 compared with recent years prior to the pandemic and explore possible reasons for the findings.\n\nConvergent parallel mixed-methods design. Collection of quantitative data from the Swedish National Board of Health and Welfare and the Swedish Pregnancy Register, and qualitative data from interviews.\n\nNational data on abortions (January 2018-June 2020) and births (January 2018-March 2021). Interviews performed at the main abortion clinic, Gothenburg, Sweden, in June 2020.\n\nAll women aged 15-44 years living in Sweden 2018-2020, approximately 1.9 million. 15 women who sought abortion were interviewed.\n\nNumber of abortions and births/1000 women aged 15-44 years. Themes and subthemes identified from interviews.\n\nThe number of abortions and ongoing pregnancies did not change significantly during the study period compared with before the pandemic started. Interview themes identified were the following: meeting with abortion care during the COVID-19 pandemic (availability, and fear of being infected and infecting others); and the impact of the COVID-19 pandemic on the abortion decision (to catch COVID-19 during pregnancy, feelings of loneliness and isolation, and social aspects).\n\nThis study shows that the number of abortions and ongoing pregnancies remained unchanged during the first wave of the COVID-19 pandemic in 2020 in Sweden compared with before the start of the pandemic. Abortion-seeking women did not hesitate to proceed with the abortion. The women expressed a number of fears concerning both availability of care and their health, which could have been properly addressed by the authorities.", "doi": "10.1136/bmjopen-2021-054076", "pmid": "35197343", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8882666"}, {"db": "pii", "key": "bmjopen-2021-054076"}], "notes": [], "created": "2023-01-13T13:33:02.465Z", "modified": "2023-01-13T13:33:02.532Z"}, {"entity": "publication", "iuid": "29818ab97c8a40bdaa3e46989a7512f3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/29818ab97c8a40bdaa3e46989a7512f3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/29818ab97c8a40bdaa3e46989a7512f3"}}, "title": "Evaluation of Simple Lateral Flow Immunoassays for Detection of SARS-CoV-2 Neutralizing Antibodies.", "authors": [{"family": "Nickel", "given": "Olaf", "initials": "O"}, {"family": "Rockstroh", "given": "Alexandra", "initials": "A", "orcid": "0000-0003-1317-5857", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0f920f4daa4468ca4826d82f45f647d.json"}}, {"family": "Borte", "given": "Stephan", "initials": "S"}, {"family": "Wolf", "given": "Johannes", "initials": "J"}], "type": "journal article", "published": "2022-02-23", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "3", "issn-l": null}, "abstract": "Immunization for the generation of protective antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged to be highly effective in preventing hospital admission, need for intensive care treatment and high mortality in the current SARS-CoV-2 pandemic. Lateral flow immune assays (LFIAs) offer a simple and competitive option to monitor antibody production after vaccination. Here, we compared the diagnostic performance of three different lateral flow assays in detecting nucleocapsid protein (NP), S1 subunit (S1) and receptor binding domain (pseudo)-neutralizing antibodies (nRBD) in sera of 107 health care workers prior (V1), two weeks (V2) after first vaccination with BNT162b2 as well as three weeks (V3) and eight months later (V4). In sera at V1, overall specificity was &gt;99%. At V3, LFIAs showed sensitivities between 98.1 and 100%. The comparison of S1 and nRBD LFIA with S1 ELISA and a focus reduction neutralization assay (FRNT) revealed high concordance at V3. Thus, the use of lateral flow immunoassays appears to have reasonable application in the short-term follow-up after vaccination for SARS-CoV-2.", "doi": "10.3390/vaccines10030347", "pmid": "35334979", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "vaccines10030347"}, {"db": "pmc", "key": "PMC8949379"}], "notes": [], "created": "2022-04-04T06:56:07.322Z", "modified": "2022-04-04T06:56:07.376Z"}, {"entity": "publication", "iuid": "2c7797a41e6e44f99348af9ff69c55fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c7797a41e6e44f99348af9ff69c55fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c7797a41e6e44f99348af9ff69c55fa"}}, "title": "Analysis of B Cell Receptor Repertoires Reveals Key Signatures of the Systemic B Cell Response after SARS-CoV-2 Infection.", "authors": [{"family": "Zhang", "given": "Yudi", "initials": "Y"}, {"family": "Yan", "given": "Qihong", "initials": "Q"}, {"family": "Luo", "given": "Kun", "initials": "K"}, {"family": "He", "given": "Ping", "initials": "P"}, {"family": "Hou", "given": "Ruitian", "initials": "R"}, {"family": "Zhao", "given": "Xinwei", "initials": "X"}, {"family": "Wang", "given": "Qian", "initials": "Q"}, {"family": "Yi", "given": "Haisu", "initials": "H"}, {"family": "Liang", "given": "Huan", "initials": "H"}, {"family": "Deng", "given": "Yijun", "initials": "Y"}, {"family": "Hu", "given": "Fengyu", "initials": "F"}, {"family": "Li", "given": "Feng", "initials": "F"}, {"family": "Liu", "given": "Xinglong", "initials": "X"}, {"family": "Feng", "given": "Ying", "initials": "Y"}, {"family": "Li", "given": "Pingchao", "initials": "P"}, {"family": "Qu", "given": "Linbing", "initials": "L"}, {"family": "Chen", "given": "Zhaoming", "initials": "Z"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}, {"family": "Feng", "given": "Liqiang", "initials": "L", "orcid": "0000-0001-6811-2074", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14d1a8f7ddbc4eeeb9f23a2efc12a2fd.json"}}, {"family": "Niu", "given": "Xuefeng", "initials": "X"}, {"family": "Chen", "given": "Ling", "initials": "L", "orcid": "0000-0003-1485-1626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b461d2c202447e6b4bc7ec60a46f51b.json"}}], "type": "journal article", "published": "2022-02-23", "journal": {"title": "J Virol", "issn": "1098-5514", "pages": "e0160021", "volume": "96", "issue": "4", "issn-l": "0022-538X"}, "abstract": "A comprehensive study of the B cell response against SARS-CoV-2 could be significant for understanding the immune response and developing therapeutical antibodies and vaccines. To define the dynamics and characteristics of the antibody repertoire following SARS-CoV-2 infection, we analyzed the mRNA transcripts of immunoglobulin heavy chain (IgH) repertoires of 24 peripheral blood samples collected between 3 and 111 days after symptom onset from 10 COVID-19 patients. Massive clonal expansion of naive B cells with limited somatic hypermutation (SHM) was observed in the second week after symptom onset. The proportion of low-SHM IgG clones strongly correlated with spike-specific IgG antibody titers, highlighting the significant activation of naive B cells in response to a novel virus infection. The antibody isotype switching landscape showed a transient IgA surge in the first week after symptom onset, followed by a sustained IgG elevation that lasted for at least 3 months. SARS-CoV-2 infection elicited poly-germ line reactive antibody responses. Interestingly, 17 different IGHV germ line genes recombined with IGHJ6 showed significant clonal expansion. By comparing the IgH repertoires that we sequenced with the 774 reported SARS-CoV-2-reactive monoclonal antibodies (MAbs), 13 shared spike-specific IgH clusters were found. These shared spike-specific IgH clusters are derived from the same lineage of several recently published neutralizing MAbs, including CC12.1, CC12.3, C102, REGN10977, and 4A8. Furthermore, identical spike-specific IgH sequences were found in different COVID-19 patients, suggesting a highly convergent antibody response to SARS-CoV-2. Our analysis based on sequencing antibody repertoires from different individuals revealed key signatures of the systemic B cell response induced by SARS-CoV-2 infection. IMPORTANCE Although the canonical delineation of serum antibody responses following SARS-CoV-2 infection has been well established, the dynamics of antibody repertoire at the mRNA transcriptional level has not been well understood, especially the correlation between serum antibody titers and the antibody mRNA transcripts. In this study, we analyzed the IgH transcripts and characterized the B cell clonal expansion and differentiation, isotype switching, and somatic hypermutation in COVID-19 patients. This study provided insights at the repertoire level for the B cell response after SARS-CoV-2 infection.", "doi": "10.1128/JVI.01600-21", "pmid": "34878902", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8865482"}], "notes": [], "created": "2021-12-12T07:15:16.732Z", "modified": "2023-06-19T15:34:31.225Z"}, {"entity": "publication", "iuid": "3a9d5263f1c44630b90a37fbb88a8ae0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a9d5263f1c44630b90a37fbb88a8ae0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a9d5263f1c44630b90a37fbb88a8ae0"}}, "title": "SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells.", "authors": [{"family": "Hammer", "given": "Quirin", "initials": "Q"}, {"family": "Dunst", "given": "Josefine", "initials": "J"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Picarazzi", "given": "Francesca", "initials": "F"}, {"family": "Wendorff", "given": "Mareike", "initials": "M"}, {"family": "Momayyezi", "given": "Pouria", "initials": "P"}, {"family": "Huhn", "given": "Ois\u00edn", "initials": "O"}, {"family": "Netskar", "given": "Herman K", "initials": "HK"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Garc\u00eda", "given": "Marina", "initials": "M"}, {"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "Sohlberg", "given": "Ebba", "initials": "E"}, {"family": "Azzimato", "given": "Valerio", "initials": "V"}, {"family": "Aouadi", "given": "Myriam", "initials": "M"}, {"family": "Karolinska COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Severe COVID-19 GWAS Group", "given": "", "initials": ""}, {"family": "Degenhardt", "given": "Frauke", "initials": "F"}, {"family": "Franke", "given": "Andre", "initials": "A"}, {"family": "Spallotta", "given": "Francesco", "initials": "F"}, {"family": "Mori", "given": "Mattia", "initials": "M"}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "R\u00fcckert", "given": "Timo", "initials": "T"}, {"family": "Romagnani", "given": "Chiara", "initials": "C"}, {"family": "Horowitz", "given": "Amir", "initials": "A"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Malmberg", "given": "Karl-Johan", "initials": "K"}], "type": "journal article", "published": "2022-02-21", "journal": {"title": "Cell Rep", "issn": "2211-1247", "issn-l": null, "volume": null, "issue": null, "pages": "110503"}, "abstract": "Natural killer (NK) cells are innate immune cells that contribute to host defense against virus infections. NK cells respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and are activated in patients with acute coronavirus disease 2019 (COVID-19). However, by which mechanisms NK cells detect SARS-CoV-2-infected cells remains largely unknown. Here, we show that the Non-structural protein 13 of SARS-CoV-2 encodes for a peptide that is presented by human leukocyte antigen E (HLA-E). In contrast with self-peptides, the viral peptide prevents binding of HLA-E to the inhibitory receptor NKG2A, thereby rendering target cells susceptible to NK cell attack. In line with these observations, NKG2A-expressing NK cells are particularly activated in patients with COVID-19 and proficiently limit SARS-CoV-2 replication in infected lung epithelial cells in vitro. Thus, these data suggest that a viral peptide presented by HLA-E abrogates inhibition of NKG2A+ NK cells, resulting in missing self-recognition.", "doi": "10.1016/j.celrep.2022.110503", "pmid": "35235832", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2211-1247(22)00239-X"}, {"db": "URL", "key": "https://covid19cellatlas.com/", "description": "https://covid19cellatlas.com/"}], "notes": [], "created": "2022-03-04T06:21:37.615Z", "modified": "2022-03-04T06:22:07.859Z"}, {"entity": "publication", "iuid": "e857ddb683104a0f8f752d24ed30fb87", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e857ddb683104a0f8f752d24ed30fb87.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e857ddb683104a0f8f752d24ed30fb87"}}, "title": "A cohort study of trauma patients in Sweden during the first months of the COVID-19 pandemic: a small reduction in trauma admissions.", "authors": [{"family": "B\u00e4ckstr\u00f6m", "given": "Denise", "initials": "D", "orcid": "0000-0003-4075-4600", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b67dde528cb4fa2b5df5ab9c15f9faa.json"}}, {"family": "Wladis", "given": "Andreas", "initials": "A", "orcid": "0000-0003-4377-0892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e5c5716282a4d63a4ade70eb160f432.json"}}], "type": "journal article", "published": "2022-02-19", "journal": {"title": "Scand J Trauma Resusc Emerg Med", "issn": "1757-7241", "volume": "30", "issue": "1", "pages": "12", "issn-l": "1757-7241"}, "abstract": "Given that Swedish authorities have been widely viewed as having practiced an unusual approach to the COVID-19 pandemic and given that Sweden is notable for a low incidence of trauma, we wanted to learn how the pandemic may have affected the number of trauma admissions in Sweden.\n\nWe conducted a retrospective cohort study based on the Swedish trauma registry (Svenska Traumaregistret). The study period was March 1, 2020 to June 30, 2020. As a basis for comparison, the record for the same time during the previous year, 2019 was used.\n\nDuring the four months of the first wave of COVID-19, 2020 there was a decline of 24.2% in the total number of trauma patients in Sweden. There was no significant change in 30-day mortality rates, 4.7% 2019 and 5.1% 2020, (p = 0.30). The number of injuries per patient was higher during the pandemic 3.8 injuries 2019 and 4.1 injuries 2020 (p = 0.02). The NISS 6, 2019 and 8, 2020 was higher during the pandemic.\n\nAs a consequence of what were seen by many as all too lenient actions taken to deal with COVID-19 in Sweden during spring 2020, there was still a reduction in trauma admissions most likely due to an adherence to the voluntary recommendations, the reduction was not as prominent as what was seen in many countries with harsher restrictions and lockdowns.", "doi": "10.1186/s13049-022-01001-9", "pmid": "35183237", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8857878"}, {"db": "pii", "key": "10.1186/s13049-022-01001-9"}], "notes": [], "created": "2023-01-13T13:43:40.759Z", "modified": "2023-01-13T13:43:40.841Z"}, {"entity": "publication", "iuid": "3f2c42bc11e742e0a6ecca5cad896f2b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f2c42bc11e742e0a6ecca5cad896f2b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f2c42bc11e742e0a6ecca5cad896f2b"}}, "title": "Prevalence and predictive factors of complementary medicine use during the first wave of the COVID-19 pandemic of 2020 in the Netherlands.", "authors": [{"family": "Mulder", "given": "Louise T C", "initials": "LTC"}, {"family": "Busch", "given": "Martine", "initials": "M"}, {"family": "Kristoffersen", "given": "Agnete E", "initials": "AE"}, {"family": "H\u00f6k Nordberg", "given": "Johanna", "initials": "J"}, {"family": "van der Werf", "given": "Esther T", "initials": "ET"}], "type": "journal article", "published": "2022-02-15", "journal": {"title": "BMC Complement Med Ther", "issn": "2662-7671", "volume": "22", "issue": "1", "pages": "43", "issn-l": null}, "abstract": "Major life changing events such as the COVID-19 pandemic may have major impact on one's health and general well-being. This study aimed to determine the prevalence and predictive factors, including gender specific differences, of Complementary Medicine (CM) use (including CM consultations, self-care management and self-help techniques) during the first wave of the COVID-19 pandemic in 2020 in the Netherlands.\n\nCM use was studied among a random representative sample (n = 1004) of the adult Dutch population using an online survey conducted from 22-27 May 2020. The survey included a modified version of I-CAM-Q and additional questions on demographic characteristics, reasons for CM use, perceived effectiveness and side effects.\n\n68.0% of the participants reported to have used CM (CM consultations (13.3%), self-management strategies (59.4%), self-help techniques (30.0%)). Most frequently reported reason of CM use was to improve general well-being (61.6%), prevention and/or treatment of COVID-19 was only reported by 10%. Perceived effectiveness of CM was high and number of experienced side effects low. Being a women, worried to get infected with COVID-19, higher education and living in northern/ middle region of the Netherlands were predictive factors to use CM.\n\nIn the Netherlands, specific groups (e.g. women/ highly educated) use CM, mainly to improve general wellbeing, and seem to benefit of it during the first months of the pandemic. The high perceived effectiveness and low reporting of side effects should encourage medical professionals and policy makers for more openness towards considering CM as being part of an integrative approach to public health in times life changing events occur.", "doi": "10.1186/s12906-022-03528-x", "pmid": "35168630", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12906-022-03528-x"}], "notes": [], "created": "2022-02-17T06:06:01.985Z", "modified": "2022-02-17T06:06:02.017Z"}, {"entity": "publication", "iuid": "1d0e188b725548c192dee5a9bea8fc74", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d0e188b725548c192dee5a9bea8fc74.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d0e188b725548c192dee5a9bea8fc74"}}, "title": "An extended version of Necessary Condition Analysis (NCA) allows more specific conclusions: an example involving well-being and resilience.", "authors": [{"family": "Sorjonen", "given": "Kimmo", "initials": "K"}, {"family": "Melin", "given": "Bo", "initials": "B"}], "type": "journal article", "published": "2022-02-15", "journal": {"title": "BMC Psychiatry", "issn": "1471-244X", "volume": "22", "issue": "1", "pages": "121", "issn-l": null}, "abstract": "After conducting necessary condition analysis (NCA), researchers have concluded that a certain, not too low, level of well-being is necessary but not sufficient for a high level of resilience. However, as acknowledged by the developers of the test, NCA only evaluates if the association between two variables is characterized by some unspecified type of non-randomness and not conditions of necessity.\n\nEarlier reported data on the association between well-being and resilience among Filipino adults (N = 533) in COVID-19 quarantine were re-analyzed with an extended version of NCA.\n\nAnalyses indicated a significant necessity effect of resilience on overall well-being, which is not logically compatible with well-being being necessary but not sufficient for resilience. Analyses with an extended version of NCA suggested that the association between overall well-being and resilience was characterized by equal degrees of necessity and sufficiency.\n\nThe original version of NCA is only capable of evaluating if the association between two variables is characterized by some unspecified type of non-randomness. The extended version of NCA allows researchers to draw more specific conclusions.", "doi": "10.1186/s12888-022-03774-w", "pmid": "35168598", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12888-022-03774-w"}], "notes": [], "created": "2022-02-17T06:06:20.614Z", "modified": "2022-02-17T06:06:20.629Z"}, {"entity": "publication", "iuid": "5f5fd2ae90834b769970e07dfc15b2ba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f5fd2ae90834b769970e07dfc15b2ba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f5fd2ae90834b769970e07dfc15b2ba"}}, "title": "Ventilator-Associated Lower Respiratory Tract Bacterial Infections in COVID-19 Compared With Non-COVID-19 Patients.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P"}, {"family": "Ternhag", "given": "Anders", "initials": "A"}, {"family": "Giske", "given": "Christian G", "initials": "CG"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "\u00d6zenci", "given": "Volkan", "initials": "V"}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Spindler", "given": "Carl", "initials": "C"}, {"family": "Hedlund", "given": "Jonas", "initials": "J"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2022-02-14", "journal": {"title": "Crit Care Med", "issn": "1530-0293", "issn-l": null}, "abstract": "Ventilator-associated lower respiratory tract infections (VA-LRTIs) are associated with prolonged length of stay and increased mortality. We aimed to investigate the occurrence of bacterial VA-LRTI among mechanically ventilated COVID-19 patients and compare these findings to non-COVID-19 cohorts throughout the first and second wave of the pandemic.\n\nRetrospective cohort study.\n\nKarolinska University Hospital, Stockholm, Sweden.\n\nAll patients greater than or equal to 18 years treated with mechanical ventilation between January 1, 2011, and December 31, 2020.\n\nNone.\n\nThe cohort consisted of 20,223 ICU episodes (479 COVID-19), with a VA-LRTI incidence proportion of 30% (129/426) in COVID-19 and 18% (1,081/5,907) in non-COVID-19 among patients ventilated greater than or equal to 48 hours. The median length of ventilator treatment for COVID-19 patients was 10 days (interquartile range, 5-18 d), which was significantly longer than for all other investigated specific diagnoses. The VA-LRTI incidence rate per 1,000 ventilator days at risk was 31 (95% CI, 26-37) for COVID-19 and 34 (95% CI, 32-36) for non-COVID-19. With COVID-19 as reference, adjusted subdistribution hazard ratios for VA-LRTI was 0.29-0.50 (95% CI, < 1) for influenza, bacterial pneumonia, acute respiratory distress syndrome, and severe sepsis, but 1.38 (95% CI, 1.15-1.65) for specific noninfectious diagnoses. Compared with COVID-19 in the first wave of the pandemic, COVID-19 in the second wave had adjusted subdistribution hazard ratio of 1.85 (95% CI, 1.14-2.99). In early VA-LRTI Staphylococcus aureus was more common and Streptococcus pneumoniae, Haemophilus influenzae, and Escherichia coli less common in COVID-19 patients, while Serratia species was more often identified in late VA-LRTI.\n\nCOVID-19 is associated with exceptionally long durations of mechanical ventilation treatment and high VA-LRTI occurrence proportions. The incidence rate of VA-LRTI was compared with the pooled non-COVID-19 cohort, however, not increased in COVID-19. Significant differences in the incidence of VA-LRTI occurred between the first and second wave of the COVID-19 pandemic.", "doi": "10.1097/CCM.0000000000005462", "pmid": "35148524", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "00003246-900000000-94988"}], "notes": [], "created": "2022-02-17T06:15:35.140Z", "modified": "2022-02-17T06:15:35.176Z"}, {"entity": "publication", "iuid": "7a8e4aefcd1740baa1e0c375af71e6fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a8e4aefcd1740baa1e0c375af71e6fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a8e4aefcd1740baa1e0c375af71e6fc"}}, "title": "COVID-19 related distress in the Swedish population: Validation of the Swedish version of the COVID Stress Scales (CSS).", "authors": [{"family": "Carlander", "given": "Anders", "initials": "A", "orcid": "0000-0002-4435-7648", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb81228e2951462ab407f261fa9e6d02.json"}}, {"family": "Lekander", "given": "Mats", "initials": "M"}, {"family": "Asmundson", "given": "Gordon J G", "initials": "GJG"}, {"family": "Taylor", "given": "Steven", "initials": "S"}, {"family": "Olofsson Bagge", "given": "Roger", "initials": "R"}, {"family": "Lindqvist Bagge", "given": "Ann-Sophie", "initials": "AS"}], "type": "journal article", "published": "2022-02-14", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "17", "issue": "2", "pages": "e0263888", "issn-l": "1932-6203"}, "abstract": "The COVID Stress Scales (CSS) assess health- and contamination-related distress in the face of a medical outbreak like the ongoing COVID-19 pandemic. Though the CSS is translated into 21 languages, it has not been validated in a Swedish national sample.\n\nOur general objective is to provide a translation, replication, and validation of the CSS and test its convergent- and discriminant validity in relation to anxiety, health anxiety, depression, and stress in the general Swedish population. We also present latent psychometric properties by modelling based on item response theory.\n\nParticipants consisted of 3044 Swedish adults (> 18 years) from a pre-stratified (gender, age, and education) sample from The Swedish Citizen Panel. Mental health status was assessed by validated instruments, including the CSS, PHQ-4, SHAI-14, and PSS-10.\n\nResults indicate that our Swedish translation of CSS has good psychometric properties and consists of 5 correlated factors.\n\nThe CSS is useful either as a unidimensional or multidimensional construct using the CSS scales to measure key facets of pandemic-related stress.\n\nThe findings support the cross-cultural validity of the CSS and its potential utility in understanding many of the emotional challenges posed by the current and future pandemics.", "doi": "10.1371/journal.pone.0263888", "pmid": "35157739", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-37902"}], "notes": [], "created": "2022-02-17T06:11:53.292Z", "modified": "2022-02-17T06:11:53.339Z"}, {"entity": "publication", "iuid": "7fab07b5f64e4a5393a2b95e5f9286dc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7fab07b5f64e4a5393a2b95e5f9286dc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7fab07b5f64e4a5393a2b95e5f9286dc"}}, "title": "Association between pharmaceutical modulation of oestrogen in postmenopausal women in Sweden and death due to COVID-19: a cohort study.", "authors": [{"family": "Sund", "given": "Malin", "initials": "M"}, {"family": "Fonseca-Rodr\u00edguez", "given": "Osvaldo", "initials": "O"}, {"family": "Josefsson", "given": "Andreas", "initials": "A"}, {"family": "Welen", "given": "Karin", "initials": "K"}, {"family": "Fors Connolly", "given": "Anne-Marie", "initials": "AM", "orcid": "0000-0001-9215-4047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff46cc7d9e374929a14350748727ba60.json"}}], "type": "journal article", "published": "2022-02-14", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "2", "pages": "e053032", "issn-l": "2044-6055"}, "abstract": "Determine whether augmentation of oestrogen in postmenopausal women decreases the risk of death following COVID-19.\n\nNationwide registry-based study in Sweden based on registries from the Swedish Public Health Agency (all individuals who tested positive for SARS-CoV-2); Statistics Sweden (socioeconomical variables) and the National Board of Health and Welfare (causes of death).\n\nPostmenopausal women between 50 and 80 years of age with verified COVID-19.\n\nPharmaceutical modulation of oestrogen as defined by (1) women with previously diagnosed breast cancer and receiving endocrine therapy (decreased systemic oestrogen levels); (2) women receiving hormone replacement therapy (increased systemic oestrogen levels) and (3) a control group not fulfilling requirements for group 1 or 2 (postmenopausal oestrogen levels). Adjustments were made for potential confounders such as age, annual disposable income (richest group as the reference category), highest level of education (primary, secondary and tertiary (reference)) and the weighted Charlson Comorbidity Index (wCCI).\n\nDeath following COVID-19.\n\nFrom a nationwide cohort consisting of 49 853 women diagnosed with COVID-19 between 4 February and 14 September 2020 in Sweden, 16 693 were between 50 and 80 years of age. We included 14 685 women in the study with 11 923 (81%) in the control group, 227 (2%) women in group 1 and 2535 (17%) women in group 2. The unadjusted ORs for death following COVID-19 were 2.35 (95% CI 1.51 to 3.65) for group 1 and 0.45 (0.34 to 0.6) for group 2. Only the adjusted OR for death remained significant for group 2 with OR 0.47 (0.34 to 0.63). Absolute risk of death was 4.6% for the control group vs 10.1% and 2.1%, for the decreased and increased oestrogen groups, respectively. The risk of death due to COVID-19 was significantly associated with: age, OR 1.15 (1.14 to 1.17); annual income, poorest 2.79 (1.96 to 3.97), poor 2.43 (91.71 to 3.46) and middle 1.64 (1.11 to 2.41); and education (primary 1.4 (1.07 to 1.81)) and wCCI 1.13 (1.1 to 1.16).\n\nOestrogen supplementation in postmenopausal women is associated with a decreased risk of dying from COVID-19 in this nationwide cohort study. These findings are limited by the retrospective and non-randomised design. Further randomised intervention trials are warranted.", "doi": "10.1136/bmjopen-2021-053032", "pmid": "35165090", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-053032"}], "notes": [], "created": "2022-02-17T06:07:13.014Z", "modified": "2022-02-17T06:07:27.088Z"}, {"entity": "publication", "iuid": "23d4b34eef6e4dc8b4019dc8d6f32450", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23d4b34eef6e4dc8b4019dc8d6f32450.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23d4b34eef6e4dc8b4019dc8d6f32450"}}, "title": "Assessment of maternal and child health care services performance in the context of COVID-19 pandemic in Addis Ababa, Ethiopia: evidence from routine service data.", "authors": [{"family": "Gebreegziabher", "given": "Senedu Bekele", "initials": "SB"}, {"family": "Marrye", "given": "Solomon Sisay", "initials": "SS"}, {"family": "Kumssa", "given": "Tsegaye Hailu", "initials": "TH"}, {"family": "Merga", "given": "Kassa Haile", "initials": "KH"}, {"family": "Feleke", "given": "Alemu Kibret", "initials": "AK"}, {"family": "Dare", "given": "Degu Jerene", "initials": "DJ"}, {"family": "Hallstr\u00f6m", "given": "Inger Kristensson", "initials": "IK"}, {"family": "Yimer", "given": "Solomon Abebe", "initials": "SA"}, {"family": "Shargie", "given": "Mulatu Biru", "initials": "MB"}], "type": "journal article", "published": "2022-02-14", "journal": {"title": "Reprod Health", "issn": "1742-4755", "volume": "19", "issue": "1", "pages": "42", "issn-l": null}, "abstract": "In many settings, health care service provision has been modified to managing COVID-19 cases, and this has been affecting the provision of maternal and child health services. The aim of this study was to assess trends in selected maternal and child health services performance in the context of COVID-19 pandemic.\n\nA cross-sectional data review was conducted in Addis Ababa, Ethiopia from April to May 2021. Routine health management information system database was reviewed from Addis Ababa Health Bureau for the period from July 2019 to March 2021 across all quarters. Proportion and mean with standard deviation were computed. T-test was used to assess statistically significant differences in services mean performance.\n\nPostnatal care visit, new contraceptives accepters, safe abortion care and number of under-5 years old children treated for pneumonia significantly decreased by 9.3% (p-value 0.04), 20.3% (p-value 0.004), 23.7% (p-value 0.01) and 77.2% (p-value < 0.001), respectively during the first 8 months of the COVID-19 pandemic compared to the previous 8 months' average performance. The trends in Antenatal care first visit, new contraceptive accepters, pentavalent-3 vaccination and under-five children treated for pneumonia began to decline in January to March 2020, a quarter when the COVID-19 pandemic began; with accelerated declines in April to June 2020 following national lockdown. The trends for the stated services began to increase during July-September 2020, the last quarter of national lockdown. Contraceptive accepters and pentavalent-1 vaccination continued to decline and showed no recovery until January-March 2021 when this study was completed.\n\nMost of the maternal and child health services performance declined following the onset of COVID-19 pandemic and national lockdown, and most of the services began recovering during July-September 2020, the last quarter of national lockdown. However, new and repeat contraceptive accepters and pentavalent-1 recipients continue to decline and show no recovery during end of the study period. Implementing COVID-19 prevention measures and assuring the community about the safety of service delivery is imperative to ensure continuity of the maternal and child health services. Regular monitoring and evaluation of services performance is required to identify slowly recovering services and respond to potentially volatile changes during the COVID-19 pandemic.", "doi": "10.1186/s12978-022-01353-6", "pmid": "35164776", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12978-022-01353-6"}], "notes": [], "created": "2022-02-17T06:08:00.863Z", "modified": "2022-02-17T06:08:11.512Z"}, {"entity": "publication", "iuid": "dae53a9eb16449ce83d40a8d36a3eb42", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dae53a9eb16449ce83d40a8d36a3eb42.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dae53a9eb16449ce83d40a8d36a3eb42"}}, "title": "Conceptual unclarity about COVID-19 ethnic disparities in Sweden: Implications for public health policy.", "authors": [{"family": "Bredstr\u00f6m", "given": "Anna", "initials": "A", "orcid": "0000-0001-5451-8540", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f5a6ad989aa4b82a0ec03e6090c16e1.json"}}, {"family": "Mulinari", "given": "Shai", "initials": "S", "orcid": "0000-0001-8773-9796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/affaf495414d44bca4566f0a37fcaf14.json"}}], "type": "journal article", "published": "2022-02-13", "journal": {"title": "Health (London)", "issn": "1461-7196", "pages": "13634593221074866", "issn-l": null}, "abstract": "The COVID-19 pandemic has shed light on abundant racial and ethnic health disparities in many countries around the world. In Sweden, statistics on COVID-19 mortality and morbidity from both the first and the second wave of the pandemic show that foreign-born individuals have been disproportionately affected, compared to Swedish-born individuals. However, as demonstrated in this article, key stakeholders including politicians, public authorities, mainstream media, and medical researchers do not draw on the same explanatory framework when conceptualizing the health disparity. Probing the different discourses that were articulated through oral and written accounts during the first wave, the article identifies three different frameworks of how ethnic health disparities in relation to COVID-19 were understood in Sweden: the socioeconomic framework, the culturalist framework and the biological framework. We discuss the importance of our findings for health policy and argue for continued interrogation of epidemiological knowledge production from a critical vantage point in order to successfully combat health inequalities.", "doi": "10.1177/13634593221074866", "pmid": "35152788", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-17T06:12:38.880Z", "modified": "2022-02-17T06:12:53.371Z"}, {"entity": "publication", "iuid": "107ba0ee394b4b7bb09b8756dbe17412", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/107ba0ee394b4b7bb09b8756dbe17412.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/107ba0ee394b4b7bb09b8756dbe17412"}}, "title": "Seroprevalence and T-cell response in 32 children 10 months after COVID-19.", "authors": [{"family": "Moritz", "given": "David", "initials": "D"}, {"family": "Krifors", "given": "Anders", "initials": "A"}, {"family": "Freyhult", "given": "Elisabeth", "initials": "E"}, {"family": "M\u00e5nsson", "given": "Emeli", "initials": "E", "orcid": "0000-0003-2867-1044", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b7d5d97f6954001a6e13398e992a01f.json"}}], "type": "journal article", "published": "2022-02-12", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253"}, "abstract": null, "doi": "10.1111/apa.16287", "pmid": "35150457", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Proteins": null}, "xrefs": [], "notes": [], "created": "2022-02-17T06:13:41.574Z", "modified": "2022-02-17T06:13:57.004Z"}, {"entity": "publication", "iuid": "6416fe9ee2414a359e25352a7fd27f1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6416fe9ee2414a359e25352a7fd27f1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6416fe9ee2414a359e25352a7fd27f1d"}}, "title": "Sequential lateral positioning as a new lung recruitment maneuver: an exploratory study in early mechanically ventilated Covid-19 ARDS patients.", "authors": [{"family": "Rold\u00e1n", "given": "Rollin", "initials": "R"}, {"family": "Rodriguez", "given": "Shalim", "initials": "S"}, {"family": "Barriga", "given": "Fernando", "initials": "F"}, {"family": "Tucci", "given": "Mauro", "initials": "M"}, {"family": "Victor", "given": "Marcus", "initials": "M"}, {"family": "Alcala", "given": "Glasiele", "initials": "G"}, {"family": "Villamonte", "given": "Ren\u00e1n", "initials": "R"}, {"family": "Su\u00e1rez-Sipmann", "given": "Fernando", "initials": "F"}, {"family": "Amato", "given": "Marcelo", "initials": "M"}, {"family": "Brochard", "given": "Laurent", "initials": "L"}, {"family": "Tusman", "given": "Gerardo", "initials": "G"}], "type": "journal article", "published": "2022-02-12", "journal": {"title": "Ann Intensive Care", "issn": "2110-5820", "volume": "12", "issue": "1", "pages": "13", "issn-l": null}, "abstract": "A sequential change in body position from supine-to-both lateral positions under constant ventilatory settings could be used as a postural recruitment maneuver in case of acute respiratory distress syndrome (ARDS), provided that sufficient positive end-expiratory pressure (PEEP) prevents derecruitment. This study aims to evaluate the feasibility and physiological effects of a sequential postural recruitment maneuver in early mechanically ventilated COVID-19 ARDS patients.\n\nA cohort of 15 patients receiving lung-protective mechanical ventilation in volume-controlled with PEEP based on recruitability were prospectively enrolled and evaluated in five sequentially applied positions for 30 min each: Supine-baseline; Lateral-1st side; 2nd Supine; Lateral-2nd side; Supine-final. PEEP level was selected using the recruitment-to-inflation ratio (R/I ratio) based on which patients received PEEP 12 cmH2O for R/I ratio \u2264 0.5 or PEEP 15 cmH2O for R/I ratio > 0.5. At the end of each period, we measured respiratory mechanics, arterial blood gases, lung ultrasound aeration, end-expiratory lung impedance (EELI), and regional distribution of ventilation and perfusion using electric impedance tomography (EIT).\n\nComparing supine baseline and final, respiratory compliance (29 \u00b1 9 vs 32 \u00b1 8 mL/cmH2O; p < 0.01) and PaO2/FIO2 ratio (138 \u00b1 36 vs 164 \u00b1 46 mmHg; p < 0.01) increased, while driving pressure (13 \u00b1 2 vs 11 \u00b1 2 cmH2O; p < 0.01) and lung ultrasound consolidation score decreased [5 (4-5) vs 2 (1-4); p < 0.01]. EELI decreased ventrally (218 \u00b1 205 mL; p < 0.01) and increased dorsally (192 \u00b1 475 mL; p = 0.02), while regional compliance increased in both ventral (11.5 \u00b1 0.7 vs 12.9 \u00b1 0.8 mL/cmH2O; p < 0.01) and dorsal regions (17.1 \u00b1 1.8 vs 18.8 \u00b1 1.8 mL/cmH2O; p < 0.01). Dorsal distribution of perfusion increased (64.8 \u00b1 7.3% vs 66.3 \u00b1 7.2%; p = 0.01).\n\nWithout increasing airway pressure, a sequential postural recruitment maneuver improves global and regional respiratory mechanics and gas exchange along with a redistribution of EELI from ventral to dorsal lung areas and less consolidation. Trial registration ClinicalTrials.gov, NCT04475068. Registered 17 July 2020, https://clinicaltrials.gov/ct2/show/NCT04475068.", "doi": "10.1186/s13613-022-00988-9", "pmid": "35150355", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13613-022-00988-9"}, {"db": "ClinicalTrials.gov", "key": "NCT04475068"}], "notes": [], "created": "2022-02-17T06:14:39.349Z", "modified": "2022-02-17T06:14:51.608Z"}, {"entity": "publication", "iuid": "ac88a0f3969e4dfa9f4b2ad6a11fc37f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac88a0f3969e4dfa9f4b2ad6a11fc37f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac88a0f3969e4dfa9f4b2ad6a11fc37f"}}, "title": "Re: Chen Dong, Sung-Lang Chen, and Wen-Wei Sung's Letter to the Editor re: Karin Wel\u00e9n, Ebba Rosendal, Magnus Gissl\u00e9n, et al. A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome: No Evidence of Benefit, Supported by Epidemiology and In Vitro Data. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2021.12.013.", "authors": [{"family": "Welen", "given": "Karin", "initials": "K"}, {"family": "Rosendal", "given": "Ebba", "initials": "E"}, {"family": "Freyhult", "given": "Eva", "initials": "E"}, {"family": "Fors Connolly", "given": "Anne-Marie", "initials": "AM"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "Josefsson", "given": "Andreas", "initials": "A"}], "type": "letter", "published": "2022-02-12", "journal": {"title": "Eur Urol", "issn": "1873-7560", "issn-l": null}, "abstract": null, "doi": "10.1016/j.eururo.2022.02.001", "pmid": "35168845", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0302-2838(22)01605-0"}], "notes": [], "created": "2022-02-17T06:05:27.796Z", "modified": "2022-02-17T06:05:27.801Z"}, {"entity": "publication", "iuid": "572357eb34bb4861a68ac67d1de20fd4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/572357eb34bb4861a68ac67d1de20fd4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/572357eb34bb4861a68ac67d1de20fd4"}}, "title": "Metabolic Rewiring and Serotonin Depletion in Patients with Post-Acute Sequelae of COVID-19.", "authors": [{"family": "Sadlier", "given": "Corinna", "initials": "C"}, {"family": "Albrich", "given": "Werner C", "initials": "WC"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}, {"family": "Lunjani", "given": "Nonhlanhla", "initials": "N"}, {"family": "Horgan", "given": "Mary", "initials": "M"}, {"family": "O'Toole", "given": "Paul W", "initials": "PW"}, {"family": "O'Mahony", "given": "Liam", "initials": "L"}], "type": "letter", "published": "2022-02-12", "journal": {"title": "Allergy", "issn": "1398-9995", "issn-l": "0105-4538"}, "abstract": null, "doi": "10.1111/all.15253", "pmid": "35150456", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-16T12:05:24.492Z", "modified": "2022-02-17T06:14:20.422Z"}, {"entity": "publication", "iuid": "ff5f3b87ac5f4a3c829af53686ae9225", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff5f3b87ac5f4a3c829af53686ae9225.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff5f3b87ac5f4a3c829af53686ae9225"}}, "title": "Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses.", "authors": [{"family": "Luttens", "given": "Andreas", "initials": "A", "orcid": "0000-0003-2915-7901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39b4f3a4039c4b6aa7e34b57cc923b47.json"}}, {"family": "Gullberg", "given": "Hjalmar", "initials": "H"}, {"family": "Abdurakhmanov", "given": "Eldar", "initials": "E"}, {"family": "Vo", "given": "Duy Duc", "initials": "DD"}, {"family": "Akaberi", "given": "Dario", "initials": "D", "orcid": "0000-0002-9595-9796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e5dfb70a38c41eea193ed13916cdf04.json"}}, {"family": "Talibov", "given": "Vladimir O", "initials": "VO"}, {"family": "Nekhotiaeva", "given": "Natalia", "initials": "N"}, {"family": "Vangeel", "given": "Laura", "initials": "L"}, {"family": "De Jonghe", "given": "Steven", "initials": "S", "orcid": "0000-0002-3872-6558", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b101386f055c47448a6c2c0ea91dfdb7.json"}}, {"family": "Jochmans", "given": "Dirk", "initials": "D"}, {"family": "Krambrich", "given": "Janina", "initials": "J"}, {"family": "Tas", "given": "Ali", "initials": "A"}, {"family": "Lundgren", "given": "Bo", "initials": "B"}, {"family": "Gravenfors", "given": "Ylva", "initials": "Y", "orcid": "0000-0001-6025-4908", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d3fad6d5ee52432db8f07099730198fe.json"}}, {"family": "Craig", "given": "Alexander J", "initials": "AJ"}, {"family": "Atilaw", "given": "Yoseph", "initials": "Y"}, {"family": "Sandstr\u00f6m", "given": "Anja", "initials": "A"}, {"family": "Moodie", "given": "Lindon W K", "initials": "LWK", "orcid": "0000-0002-9500-4535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee771ccfee70464cae2a25da0125ae82.json"}}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "van Hemert", "given": "Martijn J", "initials": "MJ"}, {"family": "Neyts", "given": "Johan", "initials": "J"}, {"family": "Lennerstrand", "given": "Johan", "initials": "J"}, {"family": "Kihlberg", "given": "Jan", "initials": "J", "orcid": "0000-0002-4205-6040", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e47b47a621b6402b935364d11e1a640a.json"}}, {"family": "Sandberg", "given": "Kristian", "initials": "K"}, {"family": "Danielson", "given": "U Helena", "initials": "UH", "orcid": "0000-0003-2728-0340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e14a218e8a44c75816b9843d0df3d0e.json"}}, {"family": "Carlsson", "given": "Jens", "initials": "J", "orcid": "0000-0003-4623-2977", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce715411f7d245f0973ab60fe2cd88c8.json"}}], "type": "journal article", "published": "2022-02-10", "journal": {"title": "J Am Chem Soc", "issn": "1520-5126", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Drugs targeting SARS-CoV-2 could have saved millions of lives during the COVID-19 pandemic, and it is now crucial to develop inhibitors of coronavirus replication in preparation for future outbreaks. We explored two virtual screening strategies to find inhibitors of the SARS-CoV-2 main protease in ultralarge chemical libraries. First, structure-based docking was used to screen a diverse library of 235 million virtual compounds against the active site. One hundred top-ranked compounds were tested in binding and enzymatic assays. Second, a fragment discovered by crystallographic screening was optimized guided by docking of millions of elaborated molecules and experimental testing of 93 compounds. Three inhibitors were identified in the first library screen, and five of the selected fragment elaborations showed inhibitory effects. Crystal structures of target-inhibitor complexes confirmed docking predictions and guided hit-to-lead optimization, resulting in a noncovalent main protease inhibitor with nanomolar affinity, a promising in vitro pharmacokinetic profile, and broad-spectrum antiviral effect in infected cells.", "doi": "10.1021/jacs.1c08402", "pmid": "35142215", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Category: Biochemistry": null, "Type: Journal article": null, "Research Area: Pandemic preparedness": null, "Funder: KAW/SciLifeLab": null, "Research Area: Drug discovery and repurposing of drugs": null}, "xrefs": [{"db": "URL", "key": "https://pubs.acs.org/doi/10.1021/jacs.1c08402.", "description": "https://pubs.acs.org/doi/10.1021/jacs.1c08402."}], "notes": [], "created": "2022-02-11T10:20:00.486Z", "modified": "2022-02-11T10:22:04.258Z"}, {"entity": "publication", "iuid": "e6dcf29c4d9547488fef7e7141f960e0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6dcf29c4d9547488fef7e7141f960e0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6dcf29c4d9547488fef7e7141f960e0"}}, "title": "Placental Tissue Destruction and Insufficiency from COVID-19 Causes Stillbirth and Neonatal Death from Hypoxic-Ischemic Injury: A Study of 68 Cases with SARS-CoV-2 Placentitis from 12 Countries.", "authors": [{"family": "Schwartz", "given": "David A", "initials": "DA"}, {"family": "Avvad-Portari", "given": "Elyzabeth", "initials": "E"}, {"family": "Bab\u00e1l", "given": "Pavel", "initials": "P"}, {"family": "Baldewijns", "given": "Marcella", "initials": "M"}, {"family": "Blomberg", "given": "Marie", "initials": "M"}, {"family": "Bouachba", "given": "Amine", "initials": "A"}, {"family": "Camacho", "given": "Jessica", "initials": "J"}, {"family": "Collardeau-Frachon", "given": "Sophie", "initials": "S"}, {"family": "Colson", "given": "Arthur", "initials": "A"}, {"family": "Dehaene", "given": "Isabelle", "initials": "I"}, {"family": "Ferreres", "given": "Joan Carles", "initials": "JC"}, {"family": "Fitzgerald", "given": "Brendan", "initials": "B"}, {"family": "Garrido-Pontnou", "given": "Marta", "initials": "M"}, {"family": "Gerges", "given": "Hazem", "initials": "H"}, {"family": "Hargitai", "given": "Beata", "initials": "B"}, {"family": "Helguera-Repetto", "given": "A Cecilia", "initials": "AC"}, {"family": "Holmstr\u00f6m", "given": "Sandra", "initials": "S"}, {"family": "Irles", "given": "Claudine Liliane", "initials": "CL"}, {"family": "Leijonhfvud", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Libbrecht", "given": "Sasha", "initials": "S"}, {"family": "Marton", "given": "Tam\u00e1s", "initials": "T"}, {"family": "McEntagart", "given": "Noel", "initials": "N"}, {"family": "Molina", "given": "James T", "initials": "JT"}, {"family": "Morotti", "given": "Raffaella", "initials": "R"}, {"family": "Nadal", "given": "Alfons", "initials": "A"}, {"family": "Navarro", "given": "Alexandra", "initials": "A"}, {"family": "Nelander", "given": "Maria", "initials": "M"}, {"family": "Oviedo", "given": "Angelica", "initials": "A"}, {"family": "Oyamada Otani", "given": "Andre Ricardo", "initials": "AR"}, {"family": "Papadogiannakis", "given": "Nikos", "initials": "N"}, {"family": "Petersen", "given": "Astrid C", "initials": "AC"}, {"family": "Roberts", "given": "Drucilla J", "initials": "DJ"}, {"family": "Saad", "given": "Ali G", "initials": "AG"}, {"family": "Sand", "given": "Anna", "initials": "A"}, {"family": "Schoenmakers", "given": "Sam", "initials": "S"}, {"family": "Sehn", "given": "Jennifer K", "initials": "JK"}, {"family": "Simpson", "given": "Preston R", "initials": "PR"}, {"family": "Thomas", "given": "Kristen", "initials": "K"}, {"family": "Valdespino-V\u00e1zquez", "given": "M Yolotzin", "initials": "MY"}, {"family": "van der Meeren", "given": "Lotte E", "initials": "LE"}, {"family": "Van Dorpe", "given": "Jo", "initials": "J"}, {"family": "Verdijk", "given": "Robert M", "initials": "RM"}, {"family": "Watkins", "given": "Jaclyn C", "initials": "JC"}, {"family": "Zaigham", "given": "Mehreen", "initials": "M"}], "type": "journal article", "published": "2022-02-10", "journal": {"title": "Arch Pathol Lab Med", "issn": "1543-2165", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Perinatal death is an increasingly important problem as the COVID-19 pandemic continues, but the mechanism of death has been unclear.\n\nTo evaluate the role of the placenta in causing stillbirth and neonatal death following maternal infection with COVID-19 and confirmed placental positivity for SARS-CoV-2.\n\nCase-based retrospective clinico-pathological analysis by a multinational group of 44 perinatal specialists from 12 countries of placental and autopsy pathology findings from 64 stillborns and 4 neonatal deaths having placentas testing positive for SARS-CoV-2 following delivery to mothers with COVID-19.\n\nAll 68 placentas had increased fibrin deposition and villous trophoblast necrosis and 66 had chronic histiocytic intervillositis, the three findings constituting SARS-CoV-2 placentitis. Sixty-three placentas had massive perivillous fibrin deposition. Severe destructive placental disease from SARS-CoV-2 placentitis averaged 77.7% tissue involvement. Other findings included multiple intervillous thrombi (37%; 25/68) and chronic villitis (32%; 22/68). The majority (19, 63%) of the 30 autopsies revealed no significant fetal abnormalities except for intrauterine hypoxia and asphyxia. Among all 68 cases, SARS-CoV-2 was detected from a body specimen in 16 of 28 cases tested, most frequently from nasopharyngeal swabs. Four autopsied stillborns had SARS-CoV-2 identified in internal organs.\n\nThe pathology abnormalities composing SARS-CoV-2 placentitis cause widespread and severe placental destruction resulting in placental malperfusion and insufficiency. In these cases, intrauterine and perinatal death likely results directly from placental insufficiency and fetal hypoxic-ischemic injury. There was no evidence that SARS-CoV-2 involvement of the fetus had a role in causing these deaths.", "doi": "10.5858/arpa.2022-0029-SA", "pmid": "35142798", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "477699"}], "notes": [], "created": "2022-02-11T10:15:45.874Z", "modified": "2022-02-17T06:16:40.734Z"}, {"entity": "publication", "iuid": "09663934bf94465288397f7dc679f5d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/09663934bf94465288397f7dc679f5d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/09663934bf94465288397f7dc679f5d0"}}, "title": "Broad anti-SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1/mRNA-1273 vaccination.", "authors": [{"family": "Kaku", "given": "Chengzi I", "initials": "CI", "orcid": "0000-0002-9854-8351", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be56dead52324203a9b37fc32f23626f.json"}}, {"family": "Champney", "given": "Elizabeth R", "initials": "ER"}, {"family": "Normark", "given": "Johan", "initials": "J", "orcid": "0000-0001-5831-4369", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cab4f084027e4e4b8f0e5113a499e5c6.json"}}, {"family": "Garcia", "given": "Marina", "initials": "M", "orcid": "0000-0002-9130-3933", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5b109d7a54e4c05a48e0f21c4432be6.json"}}, {"family": "Johnson", "given": "Carl E", "initials": "CE"}, {"family": "Ahlm", "given": "Clas", "initials": "C", "orcid": "0000-0003-2018-8592", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/833d0293b5d74bbabec63e922cd19d54.json"}}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f2dc27d02294a15a6f691be6aab641f.json"}}, {"family": "Sakharkar", "given": "Mrunal", "initials": "M", "orcid": "0000-0002-2717-5201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2694a69ce874c3f93cf4f9ed8d736dd.json"}}, {"family": "Ackerman", "given": "Margaret E", "initials": "ME", "orcid": "0000-0002-4253-3476", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10fea712c93441dd922bbcb531b46148.json"}}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE", "orcid": "0000-0001-6904-742X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e41c0e1c9c7b499fb3d844d4c572e7bb.json"}}, {"family": "Walker", "given": "Laura M", "initials": "LM", "orcid": "0000-0001-7704-3197", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a40fc6cfefc14436a12cc467c3cacd54.json"}}], "type": "journal article", "published": "2022-02-10", "journal": {"title": "Science", "issn": "1095-9203", "pages": "eabn2688", "issn-l": "0036-8075"}, "abstract": "Heterologous prime-boost immunization strategies have the potential to augment COVID-19 vaccine efficacy. We longitudinally profiled SARS-CoV-2 spike (S)-specific serological and memory B cell (MBC) responses in individuals receiving either homologous (ChAdOx1:ChAdOx1) or heterologous (ChAdOx1:mRNA-1273) prime-boost vaccination. Heterologous mRNA booster immunization induced higher serum neutralizing antibody and MBC responses against SARS-CoV-2 variants of concern (VOCs) compared to homologous ChAdOx1 boosting. Specificity mapping of circulating B cells revealed that mRNA-1273 boost immunofocused ChAdOx1-primed responses onto epitopes expressed on prefusion-stabilized S. Monoclonal antibodies isolated from mRNA-1273 boosted participants displayed overall higher binding affinities and increased breadth of reactivity against VOCs relative to those isolated from ChAdOx1-boosted individuals. Overall, the results provide molecular insight into the enhanced quality of the B cell response induced following heterologous mRNA booster vaccination.", "doi": "10.1126/science.abn2688", "pmid": "35143256", "labels": {"Category: Health": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-11T10:17:32.493Z", "modified": "2022-02-17T06:16:08.848Z"}, {"entity": "publication", "iuid": "bcdfcb32836f42e8b943b15ad2dd61a5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bcdfcb32836f42e8b943b15ad2dd61a5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bcdfcb32836f42e8b943b15ad2dd61a5"}}, "title": "Whole genome analysis and homology modeling of SARS-CoV-2 Indian isolate reveals potent FDA approved drug choice for treating COVID-19.", "authors": [{"family": "Velu", "given": "Periyannan", "initials": "P"}, {"family": "Rathinavel", "given": "Thirumalaisamy", "initials": "T", "orcid": "0000-0003-3137-5895", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25f33e7fd0634e568735a3641d573ef8.json"}}, {"family": "Kumarasamy", "given": "Suresh", "initials": "S", "orcid": "0000-0002-4931-7274", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c46cd8b2ab848aca02e70a5e1f12cd8.json"}}, {"family": "Iqbal", "given": "Muhammad Nasir", "initials": "MN", "orcid": "0000-0002-8875-8400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e141277ae6474ac2a3e1f17d1617834d.json"}}, {"family": "Noor", "given": "Hasnat", "initials": "H"}, {"family": "Ikram", "given": "Ayesha", "initials": "A"}, {"family": "Rajamanickam", "given": "Karthika", "initials": "K"}, {"family": "Shanmugam", "given": "Gnanendra", "initials": "G"}], "type": "journal article", "published": "2022-02-09", "journal": {"title": "J Biomol Struct Dyn", "issn": "1538-0254", "pages": "1-17", "issn-l": null}, "abstract": "Coronaviruses have caused enough devastation in the last two decades. These viruses have some rare features while sharing some common features. Novel coronavirus disease (nCoV-19) caused an outbreak with a fatality rate of 5%. It emerged from China and spread into many countries. The present research focused on genome analysis of Indian nCoV-19 Isolate and its translational product subjected to homology modeling and its subsequent molecular simulations to find out potent FDA approved drug for treating COVID-19. Phylogenetic analysis of SARS-CoV-2 Indian isolate shows close resemblance with 17 countries SARS-CoV-2 isolates. Homology modeling of four non-structural proteins translational product of Indian SARS-CoV-2 genome shows high similarity and allowed regions with the existing PDB deposited SARS-CoV-2 target proteins. Finally, these four generated proteins show more affinity with cobicistat, remdesivir and indinavir out of 14 screened FDA approved drugs in molecular docking which is further proven by molecular dynamics simulation and MMGBSA analysis of target ligand complex with best simulation trajectories. Overall our present research findings is that three proposed drugs namely cobicistat, remdesivir and indinavir showed higher interaction with the model SARS-CoV-2 viral target proteins from the Indian nCoV-19 isolate. These compounds could be used as a starting point for the creation of active antiviral drugs to combat the deadly COVID-19 virus during global pandemic and its subsequent viral infection waves across the globe.Communicated by Ramaswamy H. Sarma.", "doi": "10.1080/07391102.2022.2038272", "pmid": "35139758", "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-11T10:24:41.199Z", "modified": "2022-02-11T10:24:41.351Z"}, {"entity": "publication", "iuid": "d7a6ecface78453e933adb93c529d4ea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d7a6ecface78453e933adb93c529d4ea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d7a6ecface78453e933adb93c529d4ea"}}, "title": "The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury: State-of-the-Art Review.", "authors": [{"family": "Siripanthong", "given": "Bhurint", "initials": "B"}, {"family": "Asatryan", "given": "Babken", "initials": "B"}, {"family": "Hanff", "given": "Thomas C", "initials": "TC"}, {"family": "Chatha", "given": "Salman R", "initials": "SR"}, {"family": "Khanji", "given": "Mohammed Y", "initials": "MY"}, {"family": "Ricci", "given": "Fabrizio", "initials": "F"}, {"family": "Muser", "given": "Daniele", "initials": "D"}, {"family": "Ferrari", "given": "Victor A", "initials": "VA"}, {"family": "Nazarian", "given": "Saman", "initials": "S"}, {"family": "Santangeli", "given": "Pasquale", "initials": "P"}, {"family": "Deo", "given": "Rajat", "initials": "R"}, {"family": "Cooper", "given": "Leslie T", "initials": "LT"}, {"family": "Mohiddin", "given": "Saidi A", "initials": "SA"}, {"family": "Chahal", "given": "C Anwar A", "initials": "CAA"}], "type": "journal article", "published": "2022-02-09", "journal": {"title": "JACC Basic Transl Sci", "issn": "2452-302X", "issn-l": null}, "abstract": "The mechanisms of coronavirus disease 2019 (COVID-19)-related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity.", "doi": "10.1016/j.jacbts.2021.10.011", "pmid": "35165665", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2452-302X(21)00318-1"}, {"db": "pmc", "key": "PMC8828362"}], "notes": [], "created": "2022-02-17T06:06:45.486Z", "modified": "2022-02-17T06:06:45.521Z"}, {"entity": "publication", "iuid": "7616f43c137c4aa59370f1f07a770009", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7616f43c137c4aa59370f1f07a770009.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7616f43c137c4aa59370f1f07a770009"}}, "title": "Little support for a protective effect of ADT against COVID-19.", "authors": [{"family": "Josefsson", "given": "Andreas", "initials": "A", "orcid": "0000-0002-2013-0887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1ba4bf5497b4c6e9334948925e3be76.json"}}], "type": "editorial", "published": "2022-02-09", "journal": {"title": "Scand J Urol", "issn": "2168-1813", "issn-l": null, "volume": null, "issue": null, "pages": "1-2"}, "abstract": null, "doi": "10.1080/21681805.2022.2033313", "pmid": "35137649", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-11T10:24:56.477Z", "modified": "2022-02-11T10:25:30.715Z"}, {"entity": "publication", "iuid": "7673dbe3bac44bc5a6299833d4d3d98d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7673dbe3bac44bc5a6299833d4d3d98d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7673dbe3bac44bc5a6299833d4d3d98d"}}, "title": "Intimate physical contact between people from different households during the COVID-19 pandemic: a mixed-methods study from a large, quasi-representative survey (Natsal-COVID).", "authors": [{"family": "Sonnenberg", "given": "Pam", "initials": "P", "orcid": "0000-0002-1067-1583", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/703eb395b191407eb977ed908453cb30.json"}}, {"family": "Menezes", "given": "Dee", "initials": "D", "orcid": "0000-0002-1628-1228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7babe7d1c2694f6aadde9c1de8ed74be.json"}}, {"family": "Freeman", "given": "Lily", "initials": "L"}, {"family": "Maxwell", "given": "Karen J", "initials": "KJ", "orcid": "0000-0002-2264-6510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43d1a00df778443d880fac4894e93630.json"}}, {"family": "Reid", "given": "David", "initials": "D", "orcid": "0000-0001-6832-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9650baded4724b0fb749dbfea43e1632.json"}}, {"family": "Clifton", "given": "Soazig", "initials": "S", "orcid": "0000-0002-4171-0805", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7cea96a2c56409dab9f474144303c30.json"}}, {"family": "Tanton", "given": "Clare", "initials": "C", "orcid": "0000-0002-4612-1858", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adf2ed41e93f422aa32a1afe93895bed.json"}}, {"family": "Copas", "given": "Andrew", "initials": "A", "orcid": "0000-0001-8968-5963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0aee9dde1bb2497398a63252a713c88a.json"}}, {"family": "Riddell", "given": "Julie", "initials": "J", "orcid": "0000-0002-8084-4566", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9660f5597db42d19462b83c9f8a1be4.json"}}, {"family": "Dema", "given": "Emily", "initials": "E", "orcid": "0000-0002-7254-2023", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3843a1be6fc4e37ac3f8eeff9a2bbb2.json"}}, {"family": "Bos\u00f3 P\u00e9rez", "given": "Raquel", "initials": "R", "orcid": "0000-0001-7342-4566", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3d61e70a5874b4ea43a1d9d73333605.json"}}, {"family": "Gibbs", "given": "Jo", "initials": "J", "orcid": "0000-0001-5696-0260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8e88ce8b71e4ae3b03749616b5a9eab.json"}}, {"family": "Ridge", "given": "Mary-Clare", "initials": "MC", "orcid": "0000-0001-9621-4529", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fda16e5b838e4da895af4b74f233e246.json"}}, {"family": "Macdowall", "given": "Wendy", "initials": "W", "orcid": "0000-0001-5868-8336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3cfc1c64d9b84957a244f64c09b483bf.json"}}, {"family": "Unemo", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1710-2081", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed8c616c8c16456590342443393553cb.json"}}, {"family": "Bonell", "given": "Chris", "initials": "C", "orcid": "0000-0002-6253-6498", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eeec7c46459414a974c9f42cc3b2baa.json"}}, {"family": "Johnson", "given": "Anne M", "initials": "AM", "orcid": "0000-0003-1330-7100", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f878d2115174a69a8de743cc40b6a15.json"}}, {"family": "Mercer", "given": "Catherine H", "initials": "CH", "orcid": "0000-0002-4220-5034", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6332e0448a8b49c7ab019b7c75768df1.json"}}, {"family": "Mitchell", "given": "Kirstin", "initials": "K", "orcid": "0000-0002-4409-6601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2af6a4b606314786806e669e86b92ee0.json"}}, {"family": "Field", "given": "Nigel", "initials": "N", "orcid": "0000-0002-2825-6652", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a84330facf864cfe9a4a51550cea9543.json"}}], "type": "journal article", "published": "2022-02-09", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "2", "pages": "e055284", "issn-l": "2044-6055"}, "abstract": "Physical distancing as a non-pharmaceutical intervention aims to reduce interactions between people to prevent SARS-CoV-2 transmission. Intimate physical contact outside the household (IPCOH) may expand transmission networks by connecting households. We aimed to explore whether intimacy needs impacted adherence to physical distancing following lockdown in Britain in March 2020.\n\nThe Natsal-COVID web-panel survey (July-August 2020) used quota-sampling and weighting to achieve a quasi-representative population sample. We estimate reporting of IPCOH with a romantic/sexual partner in the 4 weeks prior to interview, describe the type of contact, identify demographic and behavioural factors associated with IPCOH and present age-adjusted ORs (aORs). Qualitative interviews (n=18) were conducted to understand the context, reasons and decision making around IPCOH.\n\nOf 6654 participants aged 18-59 years, 9.9% (95% CI 9.1% to 10.6%) reported IPCOH. IPCOH was highest in those aged 18-24 (17.7%), identifying as gay or lesbian (19.5%), and in steady non-cohabiting relationships (56.3%). IPCOH was associated with reporting risk behaviours (eg, condomless sex, higher alcohol consumption). IPCOH was less likely among those reporting bad/very bad health (aOR 0.54; 95% CI 0.32 to 0.93) but more likely among those with COVID-19 symptoms and/or diagnosis (aOR 1.34; 95% CI 1.10 to 1.65). Two-thirds (64.4%) of IPCOH was reported as being within a support bubble. Qualitative interviews found that people reporting IPCOH deliberated over, and made efforts to mitigate, the risks.\n\nGiven 90% of people did not report IPCOH, this contact may not be a large additional contributor to SARS-CoV-2 transmission, although heterogeneity exists within the population. Public health messages need to recognise how single people and partners living apart balance sexual intimacy and relationship needs with adherence to control measures.", "doi": "10.1136/bmjopen-2021-055284", "pmid": "35140158", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-055284"}], "notes": [], "created": "2022-02-11T10:24:02.508Z", "modified": "2022-02-11T10:24:19.538Z"}, {"entity": "publication", "iuid": "6b2601546e12410eb50fc403016bf292", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b2601546e12410eb50fc403016bf292.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b2601546e12410eb50fc403016bf292"}}, "title": "Working conditions in primary healthcare during the COVID-19 pandemic: an interview study with physicians in Sweden.", "authors": [{"family": "Fernemark", "given": "Hanna", "initials": "H", "orcid": "0000-0002-9029-4406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0cd7e6f1012a4ff08bf13b0a17385bfd.json"}}, {"family": "Skagerstr\u00f6m", "given": "Janna", "initials": "J"}, {"family": "Seing", "given": "Ida", "initials": "I"}, {"family": "H\u00e5rdstedt", "given": "Maria", "initials": "M"}, {"family": "Schildmeijer", "given": "Kristina", "initials": "K", "orcid": "0000-0002-0895-674X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05115c15c6834224851474c2635ded5d.json"}}, {"family": "Nilsen", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2022-02-08", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "2", "pages": "e055035", "issn-l": "2044-6055"}, "abstract": "The aim of this study was to explore how the COVID-19 pandemic changed the working conditions of physicians in Swedish primary healthcare.\n\nThis is a descriptive, qualitative study with individual semistructured interviews. Data were analysed using inductive content analysis.\n\nSwedish primary healthcare units in both rural and urban areas.\n\nA total of 11 primary care physicians fulfilled participation.\n\nTwo main categories emerged: 'work organisation and routines' and 'psychosocial work environment', containing three and five subcategories, respectively. The pandemic enforced changes in work organisation and routines. Increased flexibility, including more patient-oriented delivery of care, and novel means of interorganisational and intraorganisational interactions were perceived as positive by physicians. The pandemic also caused several changes in physicians' psychosocial work environment. Increased workload, information overload, as well as ethical considerations and feelings of uncertainty made the work environment stressful for physicians.\n\nThe COVID-19 pandemic affected the working conditions of physicians in Swedish primary healthcare in numerous ways. The pandemic enforced changes in work organisation and routines for physicians in primary healthcare. Further research is needed to investigate how the pandemic will affect primary healthcare in the longer term. Learning from the pandemic is important because this will not be the last crisis that primary care and its healthcare professionals will face.", "doi": "10.1136/bmjopen-2021-055035", "pmid": "35135771", "labels": {"Category: Public Health": null, "Type: Review": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC8829841"}, {"db": "pii", "key": "bmjopen-2021-055035"}], "notes": [], "created": "2022-02-11T10:35:46.204Z", "modified": "2023-01-13T14:47:38.535Z"}, {"entity": "publication", "iuid": "b84fe457b9754ffea8e728b51a1124de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b84fe457b9754ffea8e728b51a1124de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b84fe457b9754ffea8e728b51a1124de"}}, "title": "Reduced dispensing of prescribed antibiotics during the Covid-19 pandemic has not increased severe complications from common infections.", "authors": [{"family": "Norman", "given": "Christer", "initials": "C"}, {"family": "Svensson", "given": "Mikaela", "initials": "M"}, {"family": "Schmidt", "given": "Ingrid", "initials": "I"}, {"family": "Bergfeldt", "given": "Vendela S", "initials": "VS"}, {"family": "Obeid", "given": "Ragda", "initials": "R"}, {"family": "Ternhag", "given": "Anders", "initials": "A"}, {"family": "Struwe", "given": "Johan L", "initials": "JL"}], "type": "journal article", "published": "2022-02-08", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "252", "issn-l": null}, "abstract": "Sweden has seen an accelerated decline in the number of dispensed antibiotic prescriptions from an already low level during the Covid-19 pandemic. This prompted us to explore whether the decrease in antibiotic prescriptions has reached a critically low level and resulted in an increase in treatment of severe complications from common infections. The aim was to study if the accelerated decrease in antibiotic sales has led to an increase in complications in outpatients with common infections.\n\nA population-based nationwide registry study based on the Swedish Prescribed Drug Register and the National Patient Register.\n\nThe total number of dispensed antibiotic prescriptions decreased by 17% during 2020 compared to 2019. The decrease was most pronounced in younger age groups and for antibiotics targeting respiratory tract infections. The number of hospital admissions and visits to open specialist care due to pneumonia or complications related to otitis, tonsillitis, or sinusitis decreased by 4-44%. Prescriptions and numbers of visits or admissions due to urinary tract infections and skin infections remained largely unchanged compared to previous years.\n\nNo increase in complications due to common bacterial infections could be detected despite an unprecedented decline in dispensed antibiotic prescriptions in outpatient care in 2020. The decrease in dispensed antibiotic prescriptions from pharmacies was probably primarily related to a general decrease in the incidence of respiratory infections due to the recommendations and restrictions implemented to mitigate the Covid-19 pandemic in Sweden. This in return led to fewer doctors' visits and consequently to fewer occasions to prescribe antibiotics, be they warranted or not.", "doi": "10.1186/s12889-022-12692-1", "pmid": "35135517", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-022-12692-1"}], "notes": [], "created": "2022-02-11T10:36:04.989Z", "modified": "2022-02-11T10:36:05.002Z"}, {"entity": "publication", "iuid": "b80e10297ec44011b4e0af10c4361471", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b80e10297ec44011b4e0af10c4361471.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b80e10297ec44011b4e0af10c4361471"}}, "title": "NK cell frequencies, function and correlates to vaccine outcome in BNT162b2 mRNA anti-SARS-CoV-2 vaccinated healthy and immunocompromised individuals.", "authors": [{"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Boulouis", "given": "Caroline", "initials": "C"}, {"family": "Filipovic", "given": "Iva", "initials": "I"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Kammann", "given": "Tobias", "initials": "T"}, {"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Hammer", "given": "Quirin", "initials": "Q"}, {"family": "Strunz", "given": "Benedikt", "initials": "B"}, {"family": "P\u00e9rez Potti", "given": "Andr\u00e9", "initials": "A"}, {"family": "Rivera Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Lange", "given": "Joshua", "initials": "J"}, {"family": "Muvva", "given": "Jagadeeswara Rao", "initials": "JR"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Mielke", "given": "Stephan", "initials": "S"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "S\u00f6derdahl", "given": "Gunnar", "initials": "G"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "Sobkowiak", "given": "Michal J", "initials": "MJ"}, {"family": "Gabarrini", "given": "Giorgio", "initials": "G"}, {"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M"}, {"family": "Alici", "given": "Evren", "initials": "E"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG", "orcid": "0000-0003-0908-7387", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48a59f01e46c41038301a586178e8e2a.json"}}], "type": "journal article", "published": "2022-02-08", "journal": {"title": "Mol Med", "issn": "1528-3658", "volume": "28", "issue": "1", "pages": "20", "issn-l": "1076-1551"}, "abstract": "Adaptive immune responses have been studied extensively in the course of mRNA vaccination against COVID-19. Considerably fewer studies have assessed the effects on innate immune cells. Here, we characterized NK cells in healthy individuals and immunocompromised patients in the course of an anti-SARS-CoV-2 BNT162b2 mRNA prospective, open-label clinical vaccine trial. See trial registration description in notes. Results revealed preserved NK cell numbers, frequencies, subsets, phenotypes, and function as assessed through consecutive peripheral blood samplings at 0, 10, 21, and 35 days following vaccination. A positive correlation was observed between the frequency of NKG2C+ NK cells at baseline (Day 0) and anti-SARS-CoV-2 Ab titers following BNT162b2 mRNA vaccination at Day 35. The present results provide basic insights in regards to NK cells in the context of mRNA vaccination, and have relevance for future mRNA-based vaccinations against COVID-19, other viral infections, and cancer.Trial registration: The current study is based on clinical material from the COVAXID open-label, non-randomized prospective clinical trial registered at EudraCT and clinicaltrials.gov (no. 2021-000175-37). Description: https://clinicaltrials.gov/ct2/show/NCT04780659?term=2021-000175-37&draw=2&rank=1 .", "doi": "10.1186/s10020-022-00443-2", "pmid": "35135470", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null, "Research Area: Vaccine": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "10.1186/s10020-022-00443-2"}, {"db": "ClinicalTrials.gov", "key": "NCT04780659"}], "notes": [], "created": "2022-02-11T10:36:36.455Z", "modified": "2022-02-11T10:37:25.339Z"}, {"entity": "publication", "iuid": "63a75994008f423d81539733ef3c83dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63a75994008f423d81539733ef3c83dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63a75994008f423d81539733ef3c83dd"}}, "title": "Levels and Correlates of Objectively Measured Sedentary Behaviour in Young Children: SUNRISE Study Results from 19 Countries.", "authors": [{"family": "Kariippanon", "given": "Katharina E", "initials": "KE"}, {"family": "Chong", "given": "Kar Hau", "initials": "KH"}, {"family": "Janssen", "given": "Xanne", "initials": "X"}, {"family": "Tomaz", "given": "Simone A", "initials": "SA"}, {"family": "Ribeiro", "given": "Evelyn Hc", "initials": "EH"}, {"family": "Munambah", "given": "Nyaradzai", "initials": "N"}, {"family": "Chan", "given": "Cecilia Hs", "initials": "CH"}, {"family": "Chathurangana", "given": "P W Prasad", "initials": "PWP"}, {"family": "Draper", "given": "Catherine E", "initials": "CE"}, {"family": "El Hamdouchi", "given": "Asmaa", "initials": "A"}, {"family": "Florindo", "given": "Alex A", "initials": "AA"}, {"family": "Guan", "given": "Hongyan", "initials": "H"}, {"family": "Ha", "given": "Amy S", "initials": "AS"}, {"family": "Hossain", "given": "Mohammad Sorowar", "initials": "MS"}, {"family": "Kim", "given": "Dong Hoon", "initials": "DH"}, {"family": "Van Kim", "given": "Thanh", "initials": "T"}, {"family": "Koh", "given": "Denise Cl", "initials": "DC"}, {"family": "L\u00f6f", "given": "Marie", "initials": "M"}, {"family": "Pham", "given": "Bang Nguyen", "initials": "BN"}, {"family": "Poh", "given": "Bee Koon", "initials": "BK"}, {"family": "Reilly", "given": "John J", "initials": "JJ"}, {"family": "Staiano", "given": "Amanda E", "initials": "AE"}, {"family": "Suherman", "given": "Adang", "initials": "A"}, {"family": "Tanaka", "given": "Chiaki", "initials": "C"}, {"family": "Tang", "given": "Hong Kim", "initials": "HK"}, {"family": "Tremblay", "given": "Mark S", "initials": "MS"}, {"family": "Webster", "given": "E Kipling", "initials": "EK"}, {"family": "Wickramasinghe", "given": "V Pujitha", "initials": "VP"}, {"family": "Wong", "given": "Jyh Eiin", "initials": "JE"}, {"family": "Okely", "given": "Anthony D", "initials": "AD"}], "type": "journal article", "published": "2022-02-08", "journal": {"title": "Med Sci Sports Exerc", "issn": "1530-0315", "issn-l": null}, "abstract": "There is a paucity of global data on sedentary behaviour during early childhood. The purpose of this study was to examine how device-measured sedentary behaviour in young children differed across geographically, economically, and socio-demographically diverse populations, in an international sample.\n\nThis multinational, cross-sectional study included data from 1071 3-5-year-old children from 19 countries, collected between 2018 and 2020 (pre-COVID). Sedentary behaviour was measured for three consecutive days using activPAL accelerometers. Sedentary time, sedentary fragmentation and seated transport duration were calculated. Linear mixed models were used to examine the differences in sedentary behaviour variables between sex, country-level income groups, urban/rural settings, and population density.\n\nChildren spent 56% (7.4 hours) of their waking time sedentary. The longest average bout duration was 81.1 \u00b1 45.4 min, and an average of 61.1 \u00b1 50.1 min/day was spent in seated transport. Children from upper-middle-income and high-income countries spent a greater proportion of the day sedentary, accrued more sedentary bouts, had shorter breaks between sedentary bouts, and spent significantly more time in seated transport, than children from low-and lower-middle-income countries. Sex and urban/rural residential setting were not associated with any outcomes. Higher population density was associated with several higher sedentary behaviour measures.\n\nThese data advance our understanding of young children's sedentary behaviour patterns globally. Country income levels and population density appear to be stronger drivers of the observed differences, than sex or rural/urban residential setting.", "doi": "10.1249/MSS.0000000000002886", "pmid": "35142711", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "00005768-900000000-95866"}], "notes": [], "created": "2022-02-11T10:18:27.153Z", "modified": "2022-02-11T10:19:36.106Z"}, {"entity": "publication", "iuid": "9932239cb6834b7085d7a0157811c4ab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9932239cb6834b7085d7a0157811c4ab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9932239cb6834b7085d7a0157811c4ab"}}, "title": "Impact of ADAR-induced editing of minor viral RNA populations on replication and transmission of SARS-CoV-2.", "authors": [{"family": "Ringlander", "given": "Johan", "initials": "J", "orcid": "0000-0002-8483-6504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64f85af7dceb436498422e62f1a98c89.json"}}, {"family": "Fingal", "given": "Joshua", "initials": "J", "orcid": "0000-0001-7305-1026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6f14cbba252f4dbc8521a654ee524919.json"}}, {"family": "Kann", "given": "Hanna", "initials": "H", "orcid": "0000-0003-2014-5437", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/01fe861a1bdb43e3a1128c4e53c0c757.json"}}, {"family": "Prakash", "given": "Kasthuri", "initials": "K", "orcid": "0000-0002-7454-6802", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3dddc60b620149019a0be56cf5963d2a.json"}}, {"family": "Rydell", "given": "Gustaf", "initials": "G", "orcid": "0000-0001-8093-2251", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83098d13393c48f0bd17864bac898c3e.json"}}, {"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Martner", "given": "Anna", "initials": "A", "orcid": "0000-0002-6598-5221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c11a2e719c534772a129782bfb60d35c.json"}}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Horal", "given": "Peter", "initials": "P"}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K"}, {"family": "Kann", "given": "Michael", "initials": "M", "orcid": "0000-0002-9589-8022", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7f54042fa8e49d6a7580a8059eaf6e8.json"}}], "type": "journal article", "published": "2022-02-08", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "119", "issue": "6", "issn-l": "0027-8424"}, "abstract": "Adenosine deaminases acting on RNA (ADAR) are RNA-editing enzymes that may restrict viral infection. We have utilized deep sequencing to determine adenosine to guanine (A\u2192G) mutations, signifying ADAR activity, in clinical samples retrieved from 93 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients in the early phase of the COVID-19 pandemic. A\u2192G mutations were detected in 0.035% (median) of RNA residues and were predominantly nonsynonymous. These mutations were rarely detected in the major viral population but were abundant in minor viral populations in which A\u2192G was more prevalent than any other mutation (P < 0.001). The A\u2192G substitutions accumulated in the spike protein gene at positions corresponding to amino acids 505 to 510 in the receptor binding motif and at amino acids 650 to 655. The frequency of A\u2192G mutations in minor viral populations was significantly associated with low viral load (P < 0.001). We additionally analyzed A\u2192G mutations in 288,247 SARS-CoV-2 major (consensus) sequences representing the dominant viral population. The A\u2192G mutations observed in minor viral populations in the initial patient cohort were increasingly detected in European consensus sequences between March and June 2020 (P < 0.001) followed by a decline of these mutations in autumn and early winter (P < 0.001). We propose that ADAR-induced deamination of RNA is a significant source of mutated SARS-CoV-2 and hypothesize that the degree of RNA deamination may determine or reflect viral fitness and infectivity.", "doi": "10.1073/pnas.2112663119", "pmid": "35064076", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2112663119"}], "notes": [], "created": "2022-01-26T10:18:08.767Z", "modified": "2022-01-26T10:18:24.353Z"}, {"entity": "publication", "iuid": "503b3407b0e04a9caad1fea91b464a61", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/503b3407b0e04a9caad1fea91b464a61.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/503b3407b0e04a9caad1fea91b464a61"}}, "title": "Ventilation is not Depressed in Hypoxemic Patients with Acute COVID-19 Infection.", "authors": [{"family": "Kairaitis", "given": "Kristina", "initials": "K", "orcid": "0000-0002-8808-3183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3ae5783acd74a84a18d6725d96088ab.json"}}, {"family": "Harbut", "given": "Piotr", "initials": "P"}, {"family": "Hedenstierna", "given": "Goran", "initials": "G"}, {"family": "Prisk", "given": "G Kim", "initials": "GK"}, {"family": "Farrow", "given": "Catherine E", "initials": "CE"}, {"family": "Amis", "given": "Terence", "initials": "T"}, {"family": "Wagner", "given": "Peter D", "initials": "PD"}, {"family": "Malhotra", "given": "Atul", "initials": "A"}], "type": "journal article", "published": "2022-02-07", "journal": {"title": "Am J Respir Crit Care Med", "issn": "1535-4970", "issn-l": "1073-449X"}, "abstract": null, "doi": "10.1164/rccm.202109-2025LE", "pmid": "35130468", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-08T15:11:07.236Z", "modified": "2022-02-08T15:11:07.289Z"}, {"entity": "publication", "iuid": "4efe1b00c2b046248a5c147fc8aa7401", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4efe1b00c2b046248a5c147fc8aa7401.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4efe1b00c2b046248a5c147fc8aa7401"}}, "title": "The presence of serum anti-SARS-CoV-2 IgA appears to protect primary health care workers from COVID-19.", "authors": [{"family": "Hennings", "given": "Viktoria", "initials": "V", "orcid": "0000-0002-7789-8299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0111566cc8d64377a863765d0f8efa19.json"}}, {"family": "Th\u00f6rn", "given": "Karolina", "initials": "K"}, {"family": "Albinsson", "given": "Sofie", "initials": "S", "orcid": "0000-0003-2038-4286", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f8e41ce25d544cba35b78ddad3352d9.json"}}, {"family": "Lingblom", "given": "Christine", "initials": "C", "orcid": "0000-0003-1284-6911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/656c7e73de8c47eb917ef817a44f716e.json"}}, {"family": "Andersson", "given": "Kerstin", "initials": "K"}, {"family": "Andersson", "given": "Christer", "initials": "C"}, {"family": "J\u00e4rbur", "given": "Katarina", "initials": "K"}, {"family": "Pullerits", "given": "Rille", "initials": "R"}, {"family": "Idorn", "given": "Manja", "initials": "M"}, {"family": "Paludan", "given": "Soren R", "initials": "SR"}, {"family": "Eriksson", "given": "Kristina", "initials": "K"}, {"family": "Wenner\u00e5s", "given": "Christine", "initials": "C"}], "type": "journal article", "published": "2022-02-07", "journal": {"title": "Eur J Immunol", "issn": "1521-4141", "issn-l": null}, "abstract": "The patterns of humoral and cellular responses to SARS-CoV-2 were studied in Swedish primary health care workers (n = 156) for 6 months during the Covid-19 pandemic. Serum IgA and IgG to SARS-CoV-2, T cell proliferation and cytokine secretion, demographic and clinical data, PCR-verified infection, and self-reported symptoms were monitored. The multivariate method OPLS-DA was used to identify immune response patterns coupled to protection from Covid-19. Contracting Covid-19 was associated with SARS-CoV-2-specific neutralizing serum IgG, T cell, interferon-\u03b3 and granzyme B responses to SARS-CoV-2, self-reported typical Covid-19 symptoms, male sex, higher BMI and hypertension. Not contracting Covid-19 was associated with female sex, IgA-dominated or no antibody responses to SARS-CoV-2, airborne allergy, and smoking. The IgG-responders had SARS-CoV-2-specific T cell responses including a cytotoxic CD4+ T cell population expressing CD25, CD38, CD69, CD194, CD279, CTLA-4 and granzyme B. IgA-responders with no IgG response to SARS-CoV-2 constituted 10% of the study population. The IgA responses were partially neutralizing and only seen in individuals who did not succumb to Covid-19. To conclude, serum IgG-dominated responses correlated with T cell responses to SARS-CoV-2 and PCR-confirmed Covid-19, whereas IgA-dominated responses correlated with not contracting the infection. This article is protected by copyright. All rights reserved.", "doi": "10.1002/eji.202149655", "pmid": "35128644", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-08T15:12:06.038Z", "modified": "2022-02-08T15:12:36.409Z"}, {"entity": "publication", "iuid": "76290bd128cb4379b2453a6888629443", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76290bd128cb4379b2453a6888629443.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76290bd128cb4379b2453a6888629443"}}, "title": "Status of Planned and Ongoing Paediatric Trials Investigating COVID-19 Vaccines: A Cross-Sectional Study of Paediatric Clinical Trials Planned in Agreed PIPs and/or Registered in Clinical Trial Databases.", "authors": [{"family": "Christiansen", "given": "Helle", "initials": "H", "orcid": "0000-0003-4893-4622", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1e17e022f4d40a9bc2e3f04e1fb1115.json"}}, {"family": "Thirstrup", "given": "Steffen", "initials": "S"}, {"family": "Hallgreen", "given": "Christine Erikstrup", "initials": "CE"}], "type": "journal article", "published": "2022-02-07", "journal": {"title": "Ther Innov Regul Sci", "issn": "2168-4804", "issn-l": null}, "abstract": "The immune system matures throughout childhood; therefore, evidence about the safety and efficacy of vaccines for the prevention of COVID-19 in the paediatric population is important. Efficacy and safety have not been established for COVID-19 vaccines in a large part of the paediatric population at the time of the initial approval for use in adults. This study aims to provide an overview of planned and ongoing paediatric clinical trials investigating the safety and/or efficacy of COVID-19.\n\nWe identified all paediatric clinical trials investigating the safety and/or efficacy of COVID-19 vaccines in clinicaltrials.gov and clinicaltrialregister.eu, as well as all clinical trials planned in agreed PIPs (Paediatric Investigational Plans) as of 11 June 2021. Information about the study design, the paediatric age groups that they included, and the primary and secondary safety and efficacy outcomes were collected, together with expected timelines for the studies.\n\n21 clinical trials were identified through the clinical trial registries and 19 clinical trials were specified in 6 agreed PIPs, 5 of these trials were also in the trial registers. All PIPs stipulated development of the COVID-19 vaccines for the full paediatric population, with a deferral. The earliest expected completion date of a PIPs is March 2024. The majority (14/21) of registered trials are randomised double-blinded studies. All investigated safety, 20 have a surrogate efficacy outcome (immunogenicity), of these 7 also measure clinical efficacy (COVID-19 infections). 18 studies were initiated, of these, all but one is still ongoing and one in adolescents has been finalised.\n\nEven though several trials have been planned in agreed PIPs, the registered paediatric clinical trials identified are most often not part of a PIP.", "doi": "10.1007/s43441-021-00356-y", "pmid": "35129826", "labels": {"Category: Health": null, "Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s43441-021-00356-y"}], "notes": [], "created": "2022-02-08T15:11:35.057Z", "modified": "2022-02-08T15:11:35.125Z"}, {"entity": "publication", "iuid": "54881f5454a14988b68f80c0062998ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54881f5454a14988b68f80c0062998ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54881f5454a14988b68f80c0062998ff"}}, "title": "Corrigendum to \"Presymptomatic viral shedding and infective ability of SARS-CoV-2; a case report\" <[Heliyon Volume 7, Issue 2, February 2021, Article e06328]>.", "authors": [{"family": "Nissen", "given": "Karolina", "initials": "K"}, {"family": "Hagbom", "given": "Marie", "initials": "M"}, {"family": "Krambrich", "given": "Janina", "initials": "J"}, {"family": "Akaberi", "given": "Dario", "initials": "D"}, {"family": "Sharma", "given": "Sumit", "initials": "S"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Svensson", "given": "Lennart", "initials": "L"}, {"family": "Bondeson", "given": "K\u00e5re", "initials": "K"}, {"family": "Salaneck", "given": "Erik", "initials": "E"}], "type": "published erratum", "published": "2022-02-05", "journal": {"title": "Heliyon", "issn": "2405-8440", "pages": "e08906", "issn-l": null}, "abstract": "[This corrects the article DOI: 10.1016/j.heliyon.2021.e06328.].", "doi": "10.1016/j.heliyon.2022.e08906", "pmid": "35155841", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(22)00194-3"}, {"db": "pmc", "key": "PMC8816836"}], "notes": [], "created": "2022-02-17T06:12:14.171Z", "modified": "2022-02-17T06:12:14.177Z"}, {"entity": "publication", "iuid": "40c1407d4e1d4e958520c51db97cdfc0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/40c1407d4e1d4e958520c51db97cdfc0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/40c1407d4e1d4e958520c51db97cdfc0"}}, "title": "Anti-SARS-CoV-2 Action of 5\u03b1-Reductase Inhibitors May be Mediated by Dehydroepiandrosterone.", "authors": [{"family": "Papadopoulos", "given": "Konstantinos I", "initials": "KI", "orcid": "0000-0003-0041-7853", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/57c63fdf7036465686e79794a5107544.json"}}, {"family": "Papadopoulou", "given": "Alexandra", "initials": "A", "orcid": "0000-0002-7488-8271", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9000ff7673bc4d35bde729ce8829ab5d.json"}}, {"family": "Sutheesophon", "given": "Warachaya", "initials": "W", "orcid": "0000-0002-1823-3852", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fab7d634e454e24989da629eafe21dc.json"}}, {"family": "Aw", "given": "Tar-Choon", "initials": "TC", "orcid": "0000-0002-7814-8836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f95d6a8535d41fbb7b5cf40fb091205.json"}}], "type": "letter", "published": "2022-02-04", "journal": {"title": "J Urol", "issn": "1527-3792", "pages": "101097JU0000000000002469", "issn-l": null}, "abstract": null, "doi": "10.1097/JU.0000000000002469", "pmid": "35119308", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2022-02-06T16:45:38.320Z", "modified": "2022-02-08T15:18:26.096Z"}, {"entity": "publication", "iuid": "18b782025bf84c03a2034b37e4eb7d15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18b782025bf84c03a2034b37e4eb7d15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18b782025bf84c03a2034b37e4eb7d15"}}, "title": "RT-PCR cycle threshold value in combination with visual scoring of chest computed tomography at hospital admission predicts outcome in COVID-19.", "authors": [{"family": "Ingberg", "given": "Edvin", "initials": "E"}, {"family": "Ahlstrand", "given": "Erik", "initials": "E"}, {"family": "Cajander", "given": "Per", "initials": "P"}, {"family": "L\u00f6f", "given": "Erika", "initials": "E"}, {"family": "Sundqvist", "given": "Martin", "initials": "M"}, {"family": "Wegener", "given": "Matthias", "initials": "M"}, {"family": "Lid\u00e9n", "given": "Mats", "initials": "M", "orcid": "0000-0002-1346-1450", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2a16a7027194ab9a32ab284641491a4.json"}}, {"family": "Cajander", "given": "Sara", "initials": "S"}], "type": "journal article", "published": "2022-02-03", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "pages": "1-10", "issn-l": "2374-4235"}, "abstract": "COVID-19 has a most variable prognosis. Several risk factors for an unfavourable outcome have been identified including extensive lung involvement on chest CT and high viral load estimated by RT-PCR cycle threshold (Ct) values. We investigated Ct value for outcome prediction, relation between Ct value and extent of lung involvement on chest CT and the combination of Ct value and chest CT lung involvement to predict outcome in COVID-19.\n\nPopulation-based retrospective study on all patients (n = 286) hospitalised for COVID-19 in \u00d6rebro Region, Sweden, between 1 March and 31 August 2020. Nasopharyngeal samples and chest CT at hospital admission were evaluated in relation to outcome of COVID-19.\n\nBoth Ct value and chest CT lung involvement were independently associated with risk for ICU admission or death. Lung involvement was superior as a single parameter, but addition of Ct value increased the prediction performance. Ct value was especially useful to identify patients with high risk for severe disease despite limited lung involvement.\n\nThe addition of RT-PCR Ct value to the assessment of lung involvement on chest CT adds valuable prognostic information in COVID-19. We believe that this information can be used to support clinical decision-making when managing COVID-19 patients.", "doi": "10.1080/23744235.2022.2035428", "pmid": "35114897", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-06T16:47:42.595Z", "modified": "2022-02-06T16:47:42.658Z"}, {"entity": "publication", "iuid": "29ba0134e3e54eb69d2f4b296a8d79b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/29ba0134e3e54eb69d2f4b296a8d79b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/29ba0134e3e54eb69d2f4b296a8d79b3"}}, "title": "ESCMID guidelines on testing for SARS-CoV-2 in asymptomatic individuals to prevent transmission in the healthcare setting.", "authors": [{"family": "Carrara", "given": "Elena", "initials": "E"}, {"family": "Ong", "given": "David S Y", "initials": "DSY"}, {"family": "Hussein", "given": "Khetam", "initials": "K"}, {"family": "Keske", "given": "Siran", "initials": "S"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}, {"family": "Presterl", "given": "Elisabeth", "initials": "E"}, {"family": "Tsioutis", "given": "Constantinos", "initials": "C"}, {"family": "Tschudin-Sutter", "given": "Sarah", "initials": "S"}, {"family": "Tacconelli", "given": "Evelina", "initials": "E"}], "type": "journal article", "published": "2022-02-03", "journal": {"title": "Clin Microbiol Infect", "issn": "1469-0691", "issn-l": null}, "abstract": "This guideline addresses the indications for direct testing of SARS-CoV-2 in asymptomatic individuals in healthcare facilities with the aim to prevent SARS-CoV-2 transmissions in these settings. The benefit of testing asymptomatic individuals to create a safe environment for patients and healthcare workers must be weighed against potential unintended consequences including delaying necessary treatments due to false positive results and lower quality of care due to strict isolation measures.\n\nA total of 9 PICOs on the topic of testing asymptomatic individuals was selected by the panel members. Subsequently, a literature search for existing guidelines and systematic reviews was performed on Pubmed, Epistemonikos, and RecMap using relevant filters available in each database. Data about article/recommendation type, setting, target population, intervention, and quality of the evidence were extracted. Credibility of the systematic reviews were evaluated using the AMSTAR-tool, and level of agreement with available recommendation was evaluated with the AGREE II-score. Because the evidence available from systematic reviews was deemed insufficiently updated to formulate relevant recommendations, an additional search targeting relevant guidance documents from major public health institutions and original studies was performed. Provisional recommendations were discussed via web conferences until agreement was reached and final recommendations was formulated according to the GRADE approach. Questions addressed by the guideline and recommendations: Recommendations were formulated regarding systematic testing in asymptomatic individuals upon admission to a healthcare setting, during hospital stay, prior to elective procedures, and prior to scheduled non-surgical procedures. Moreover, recommendations regarding testing of asymptomatic visitors, personal caregivers and healthcare workers in healthcare facilities were presented. Also, recommendations were given on contact tracing in asymptomatic patients or healthcare workers, and the possibility of a negative screening test to shorten the quarantine period. Furthermore, if applicable, recommendations were specified to transmission rate and vaccination coverage.", "doi": "10.1016/j.cmi.2022.01.007", "pmid": "35124258", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(22)00030-1"}], "notes": [], "created": "2022-02-08T15:16:03.487Z", "modified": "2022-02-08T15:16:03.501Z"}, {"entity": "publication", "iuid": "4a81b2ae9bc84e28a41303f76a7ba873", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4a81b2ae9bc84e28a41303f76a7ba873.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4a81b2ae9bc84e28a41303f76a7ba873"}}, "title": "Clinical and histology features as predictor of severity of mucormycosis in post-COVID-19 patients: An experience from a rural tertiary setting in Central India.", "authors": [{"family": "Jain", "given": "Kavita", "initials": "K", "orcid": "0000-0002-2024-9861", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/765cbc86e8fc41b3818f457b82bcc442.json"}}, {"family": "Surana", "given": "Akshay", "initials": "A"}, {"family": "Choudhary", "given": "Tej Singh", "initials": "TS"}, {"family": "Vaidya", "given": "Sudhakar", "initials": "S"}, {"family": "Nandedkar", "given": "Shirish", "initials": "S"}, {"family": "Purohit", "given": "Manju", "initials": "M", "orcid": "0000-0001-5385-7305", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4b7ea75e9964d40b1d34c569f4197f1.json"}}], "type": "journal article", "published": "2022-02-03", "journal": {"title": "SAGE Open Med", "issn": "2050-3121", "volume": "10", "pages": "20503121221074785", "issn-l": null}, "abstract": "An upsurge in cases of rhinosinusitis with or without associated orbital and/or cerebral involvement by mucormycosis has been observed in post-COVID-19 patients. Our objective is to evaluate the clinical and histopathology features of these patients to determine the severity and develop a scoring on the extent on tissue invasion.\n\nWe prospectively enrolled and analyzed 95 post-COVID-19 patients who presented with the invasive mucormycosis of the head and neck region. Clinical and histology details were noted in predesigned forms. Various histology variables were graded from I to III to propose a scoring system for the severity of the disease.\n\nMucormycosis was common in males with a mean age of 46.8 \u00b1 11 years. Facial pain was the most common presenting complaint and 77% of the patients were diabetic. Most cases (n = 59) showed a moderate degree of neutrophilic infiltrate with \u2a7e50% tissue necrosis and angioinvasion in three or more vessels with a fungal load of 2+/3+. Histology severity grade III was observed in patients who died from cerebral mucormycosis (n = 3) and septicemia (n = 2) and in patients who had undergone orbital exenteration (n = 6).\n\nThe histopathology and severity score classification was directly correlated with the outcome of the patients. Further evaluation and a larger study will help to validate the proposed scoring for its clinical use in all forms and causes of mucormycosis.", "doi": "10.1177/20503121221074785", "pmid": "35140976", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1177_20503121221074785"}, {"db": "pmc", "key": "PMC8819781"}], "notes": [], "created": "2022-02-11T10:23:44.934Z", "modified": "2022-02-11T10:23:45.065Z"}, {"entity": "publication", "iuid": "30b1695564e547bc94c8255556c21995", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/30b1695564e547bc94c8255556c21995.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/30b1695564e547bc94c8255556c21995"}}, "title": "COVID-19 vaccination in the setting of mastocytosis - Pfizer-BioNTech mRNA vaccine is safe and well-tolerated.", "authors": [{"family": "Lazarinis", "given": "Nikolaos", "initials": "N"}, {"family": "Bossios", "given": "Apostolos", "initials": "A"}, {"family": "G\u00fclen", "given": "Theo", "initials": "T"}], "type": "journal article", "published": "2022-02-02", "journal": {"title": "J Allergy Clin Immunol Pract", "issn": "2213-2201", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jaip.2022.01.037", "pmid": "35123098", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2213-2198(22)00117-9"}, {"db": "pmc", "key": "PMC8810433"}], "notes": [], "created": "2022-02-06T16:44:49.496Z", "modified": "2022-02-08T15:17:54.397Z"}, {"entity": "publication", "iuid": "f7f150de5b4244bc8f2c07f33b2b57ab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7f150de5b4244bc8f2c07f33b2b57ab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7f150de5b4244bc8f2c07f33b2b57ab"}}, "title": "Analytical observational study evaluating global pandemic preparedness and the effectiveness of early COVID-19 responses in Ethiopia, Nigeria, Singapore, South Korea, Sweden, Taiwan, UK and USA.", "authors": [{"family": "Nikolaeva", "given": "Alexandra", "initials": "A", "orcid": "0000-0001-9876-8250", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72b6128366414c6abb9a9a53c6fe605b.json"}}, {"family": "Versnel", "given": "Jenny", "initials": "J"}], "type": "journal article", "published": "2022-02-02", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "2", "pages": "e053374", "issn-l": "2044-6055"}, "abstract": "An analysis of early country-specific COVID-19 strategies and the impact of policies, healthcare resources and cultural influences on their effectiveness.\n\nAnalytical observational study.\n\nUSA, UK, Sweden, South Korea, Singapore, Taiwan, Ethiopia and Nigeria.\n\nOxCGRT indices were used to quantify variations in governments' responses, and effectiveness was measured by the number of deaths as a proportion of the population. Hofstede's cultural dimensions, and the availability of healthcare resources, were analysed for their potential impact on effectiveness.\n\nEffective strategies reflect factors such as speed of governmental intervention, cultural norms, population demographics and available resources. While biases, confounders and lack of data at the beginning of the pandemic make inferences challenging, publicly available data suggest that South Korea, Singapore and Taiwan were most successful through rapid identification and isolation of cases, and effective contact tracing systems.\n\nThe rapid spread of the highly transmissible SARS-CoV-2 virus took many countries by surprise and the delayed global response contributed to the severity of the COVID-19 pandemic. The speed at which strategies were implemented is highly correlated to the number of deaths. Factors such as cultural norms and healthcare resources impact effectiveness significantly, implying that implementation of a global 'one size fits all' approach is challenging. Global preparedness should focus on effective surveillance and preparedness strategies to enable timely identification and containment of future threats.", "doi": "10.1136/bmjopen-2021-053374", "pmid": "35110318", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-053374"}, {"db": "pmc", "key": "PMC8811275"}], "notes": [], "created": "2022-02-06T16:49:10.101Z", "modified": "2022-02-06T16:49:10.157Z"}, {"entity": "publication", "iuid": "1e0441ac55c94d91855aaf702ae739a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1e0441ac55c94d91855aaf702ae739a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1e0441ac55c94d91855aaf702ae739a1"}}, "title": "Allergies and COVID-19 vaccines: An ENDA/EAACI Position paper.", "authors": [{"family": "Barbaud", "given": "Annick", "initials": "A"}, {"family": "Garvey", "given": "Lene Heise", "initials": "LH", "orcid": "0000-0002-7777-4501", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77c921b2de6f4d9ea19c1cfea043c502.json"}}, {"family": "Arcolaci", "given": "Alessandra", "initials": "A"}, {"family": "Brockow", "given": "Knut", "initials": "K", "orcid": "0000-0002-2775-3681", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91fc8e9e37ab420fbf2a18c3eb063b71.json"}}, {"family": "Mori", "given": "Francesca", "initials": "F"}, {"family": "Mayorga", "given": "Cristobalina", "initials": "C"}, {"family": "Bonadonna", "given": "Patrizia", "initials": "P", "orcid": "0000-0002-5703-5314", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/220301cdd99d401095b70eadd8cb4b30.json"}}, {"family": "Atanaskovic-Markovic", "given": "Marina", "initials": "M", "orcid": "0000-0003-1354-6072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83efadf622ac4e8f975a4f7edddcda71.json"}}, {"family": "Moral", "given": "Luis", "initials": "L", "orcid": "0000-0002-7066-6073", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e60105059bd74801b78fba9826622c0c.json"}}, {"family": "Zanoni", "given": "Giovanna", "initials": "G"}, {"family": "Pagani", "given": "Mauro", "initials": "M", "orcid": "0000-0002-0591-5416", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c1524ff0274c68a642c8a82c5a63fb.json"}}, {"family": "Soria", "given": "Ang\u00e8le", "initials": "A", "orcid": "0000-0002-8726-6658", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/38633c9e786c45118b3192482cee8436.json"}}, {"family": "Jo\u0161t", "given": "Maja", "initials": "M"}, {"family": "Caubet", "given": "Jean-Christoph", "initials": "JC", "orcid": "0000-0001-5006-5724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8db20fc3c6842688b8f3be3f8742ef6.json"}}, {"family": "Abreu", "given": "Carmo", "initials": "C"}, {"family": "Al-Ahmad", "given": "Mona", "initials": "M"}, {"family": "Alvarez-Perea", "given": "Alberto", "initials": "A", "orcid": "0000-0001-7417-7309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e765e633592843ac887bbf59b533a8be.json"}}, {"family": "Bavbek", "given": "Sevim", "initials": "S", "orcid": "0000-0002-7884-0830", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd4648dd8218433d9891c4a100cd6495.json"}}, {"family": "Benedetta", "given": "Biagioni", "initials": "B"}, {"family": "Beatrice", "given": "Bilo M", "initials": "BM"}, {"family": "Blanca-L\u00f3pez", "given": "Natalia", "initials": "N", "orcid": "0000-0002-1492-9887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb6e84df33bc4b608b0a512b017d2a95.json"}}, {"family": "Bogas Herrera", "given": "G\u00e1dor", "initials": "G"}, {"family": "Buonomo", "given": "Alessandro", "initials": "A"}, {"family": "Calogiuri", "given": "Gianfranco", "initials": "G"}, {"family": "Carli", "given": "Giulia", "initials": "G", "orcid": "0000-0001-6400-9205", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1512d6895f1342d0aef6d2d669e5b638.json"}}, {"family": "Cernadas", "given": "Josefina", "initials": "J"}, {"family": "Cortellini", "given": "Gabriele", "initials": "G"}, {"family": "Celik", "given": "G\u00fclfem", "initials": "G", "orcid": "0000-0001-8654-513X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0bed9b33057341268ed0b5f0c00fc4db.json"}}, {"family": "Demir", "given": "Semra", "initials": "S"}, {"family": "Do\u00f1a", "given": "Inmaculada", "initials": "I", "orcid": "0000-0002-5309-4878", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32509c221e7e473faf9d8170af50cd19.json"}}, {"family": "Dursun Adile", "given": "Berna", "initials": "B"}, {"family": "Eberlein", "given": "Bernadette", "initials": "B", "orcid": "0000-0003-4509-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c7c092fc4c042f19a95fb904663bb7e.json"}}, {"family": "Emilia", "given": "Faria", "initials": "F"}, {"family": "Bryan", "given": "Fernandes", "initials": "F"}, {"family": "Garcez", "given": "Tomaz", "initials": "T"}, {"family": "Garcia-Nunez", "given": "Ignacio", "initials": "I"}, {"family": "Gawlik", "given": "Radoslaw", "initials": "R"}, {"family": "Gelincik", "given": "Asli", "initials": "A", "orcid": "0000-0002-3524-9952", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/266358f8a2974b5aa5fe91c75dcb9fcf.json"}}, {"family": "Gomes", "given": "Eva", "initials": "E"}, {"family": "Gooi", "given": "Jimmy Hc", "initials": "JH"}, {"family": "Grosber", "given": "Martine", "initials": "M"}, {"family": "G\u00fclen", "given": "Theo", "initials": "T"}, {"family": "Hacard", "given": "Florence", "initials": "F"}, {"family": "Cyrille", "given": "Hoarau", "initials": "H"}, {"family": "Janson", "given": "Christer", "initials": "C"}, {"family": "Johnston", "given": "Sebastian L", "initials": "SL"}, {"family": "Joerg", "given": "Lukas", "initials": "L", "orcid": "0000-0003-1512-4279", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e3fbf9104f74debab2cf215b242ad9a.json"}}, {"family": "Kepil \u00d6zdemir", "given": "Se\u00e7il", "initials": "S", "orcid": "0000-0003-2688-9867", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92809dfd8abd4491a916e5eb028c0c63.json"}}, {"family": "Klimek", "given": "Ludger", "initials": "L", "orcid": "0000-0002-2455-0192", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/faa1bbfb4833469db8c698a323958747.json"}}, {"family": "Ko\u0161nik", "given": "Mitja", "initials": "M", "orcid": "0000-0002-4701-7374", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27bf299d920c43559b858bdf014078be.json"}}, {"family": "Kowalski", "given": "Marek L", "initials": "ML"}, {"family": "Kuyucu", "given": "Semanur", "initials": "S"}, {"family": "Kvedariene", "given": "Violeta", "initials": "V"}, {"family": "Julio Laguna", "given": "Jose", "initials": "J"}, {"family": "Carla", "given": "Lombardo", "initials": "L"}, {"family": "Marinho", "given": "Susana", "initials": "S"}, {"family": "Merk", "given": "Hans", "initials": "H"}, {"family": "Meucci", "given": "Elisa", "initials": "E"}, {"family": "Morisset", "given": "Martine", "initials": "M", "orcid": "0000-0002-4028-703X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20f59dfbd72747db87c4a767899e6f82.json"}}, {"family": "Munoz-Cano", "given": "Rosa", "initials": "R", "orcid": "0000-0001-8566-8285", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4775ffb585f64514b502f7340b5d097e.json"}}, {"family": "Murzilli", "given": "Francesco", "initials": "F"}, {"family": "Nakonechna", "given": "Alla", "initials": "A"}, {"family": "Popescu", "given": "Florin-Dan", "initials": "FD"}, {"family": "Porebski", "given": "Grzegorz", "initials": "G", "orcid": "0000-0002-6146-0188", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d1ad79789ab45a5a022e7921f2655cd.json"}}, {"family": "Radice", "given": "Anna", "initials": "A"}, {"family": "Regateiro", "given": "Frederico S", "initials": "FS"}, {"family": "R\u00f6ckmann", "given": "Heike", "initials": "H"}, {"family": "Romano", "given": "Antonino", "initials": "A"}, {"family": "Sargur", "given": "Ravishankar", "initials": "R", "orcid": "0000-0002-8535-630X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b4169bbedcf4f6785f2077772d123ce.json"}}, {"family": "Sastre", "given": "Joaquin", "initials": "J"}, {"family": "Kathrin", "given": "Scherer Hofmeier", "initials": "SH"}, {"family": "Lenka", "given": "Sedl\u00e1\u010dkov\u00e1", "initials": "S"}, {"family": "Marta", "given": "Sobotkova", "initials": "S", "orcid": "0000-0003-3864-8008", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ca2adee8d1f4c94a69666cff8c20729.json"}}, {"family": "Ingrid", "given": "Terreehorst", "initials": "T"}, {"family": "Treudler", "given": "Regina", "initials": "R"}, {"family": "Walusiak-Skorupa", "given": "Jolanta", "initials": "J"}, {"family": "Wedi", "given": "Bettina", "initials": "B", "orcid": "0000-0002-9868-6308", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9715672937a4be5aad8eced12db8722.json"}}, {"family": "W\u00f6hrl", "given": "Stefan", "initials": "S", "orcid": "0000-0002-6324-0007", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89ec6d306f3f4fd98d35536a513277b8.json"}}, {"family": "Zidarn", "given": "Mihael", "initials": "M"}, {"family": "Zuberbier", "given": "Torsten", "initials": "T", "orcid": "0000-0002-1466-8875", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7dc091f64a240fd8fb6443292b812c6.json"}}, {"family": "Agache", "given": "Ioana", "initials": "I", "orcid": "0000-0001-7994-364X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25d9598f74414a38a868c2bcf545e94d.json"}}, {"family": "Torres", "given": "Maria J", "initials": "MJ", "orcid": "0000-0001-5228-471X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6558e75ee5494904a135d8cfe05c1927.json"}}], "type": "journal article", "published": "2022-02-02", "journal": {"title": "Allergy", "issn": "1398-9995", "issn-l": "0105-4538"}, "abstract": "Anaphylaxis, which is rare, has been reported after COVID 19 vaccination, but its management is not standardized.\n\nMembers of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interested in drug allergy participated in an online questionnaire on pre-vaccination screening and management of allergic reactions to COVID-19 vaccines, and literature was analysed.\n\nNo death due to anaphylaxis to COVID-19 vaccines has been confirmed in scientific literature. Potential allergens, polyethylene glycol (PEG), polysorbate and tromethamine, are excipients. The authors propose allergy evaluation of persons with the following histories: 1-anaphylaxis to injectable drug or vaccine containing PEG or derivatives; 2- anaphylaxis to oral/topical PEG containing products; 3-recurrent anaphylaxis of unknown cause; 4-suspected or confirmed allergy to any mRNA vaccine, 5-confirmed allergy to PEG or derivatives. We recommend a prick-to-prick skin test with the left over solution in the suspected vaccine vial to avoid waste. Prick test panel should include PEG 4000 or 3500, PEG 2000 and polysorbate 80. The value of in vitro test is arguable.\n\nThese recommendations, will lead to a better knowledge of the management and mechanisms involved in anaphylaxis to COVID-19 vaccines and enable more people with history of allergy to be vaccinated.", "doi": "10.1111/all.15241", "pmid": "35112371", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-06T16:47:24.640Z", "modified": "2022-02-06T16:47:25.500Z"}, {"entity": "publication", "iuid": "43321e1f33754836912d2d42cb4e6111", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/43321e1f33754836912d2d42cb4e6111.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/43321e1f33754836912d2d42cb4e6111"}}, "title": "Self-reported COVID-19 vaccine hesitancy and uptake among participants from different racial and ethnic groups in the United States and United Kingdom.", "authors": [{"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Merino", "given": "Jordi", "initials": "J", "orcid": "0000-0001-8312-1438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12ab049914a542b39affcfb4196861d2.json"}}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Lo", "given": "Chun-Han", "initials": "CH", "orcid": "0000-0001-8202-4513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a0d9111318f4084b64f47b5b56c8c85.json"}}, {"family": "Kwon", "given": "Sohee", "initials": "S", "orcid": "0000-0002-4201-9522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/850aeda246cd44e88071b97d54b358b5.json"}}, {"family": "Wang", "given": "Kai", "initials": "K"}, {"family": "Graham", "given": "Mark S", "initials": "MS"}, {"family": "Polidori", "given": "Lorenzo", "initials": "L"}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874802ae65824a90ba50eabdeabb8356.json"}}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Anyane-Yeboa", "given": "Adjoa", "initials": "A"}, {"family": "Astley", "given": "Christina M", "initials": "CM", "orcid": "0000-0002-5063-8470", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98ce30ec7a7d45389d75aba2defce392.json"}}, {"family": "Warner", "given": "Erica T", "initials": "ET"}, {"family": "Hu", "given": "Christina Y", "initials": "CY"}, {"family": "Selvachandran", "given": "Somesh", "initials": "S"}, {"family": "Davies", "given": "Richard", "initials": "R", "orcid": "0000-0003-2050-3994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b82cc92615f462d9af0153a6fb94fde.json"}}, {"family": "Nash", "given": "Denis", "initials": "D"}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74cf1f7094744ee289fa5df041e7cb5b.json"}}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-7284-6767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeefbf47fd384d5390109fe1a903bd18.json"}}, {"family": "COPE Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2022-02-01", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "636", "issn-l": "2041-1723"}, "abstract": "Worldwide, racial and ethnic minorities have been disproportionately impacted by COVID-19 with increased risk of infection, its related complications, and death. In the initial phase of population-based vaccination in the United States (U.S.) and United Kingdom (U.K.), vaccine hesitancy may result in differences in uptake. We performed a cohort study among U.S. and U.K. participants who volunteered to take part in the smartphone-based COVID Symptom Study (March 2020-February 2021) and used logistic regression to estimate odds ratios of vaccine hesitancy and uptake. In the U.S. (n = 87,388), compared to white participants, vaccine hesitancy was greater for Black and Hispanic participants and those reporting more than one or other race. In the U.K. (n = 1,254,294), racial and ethnic minority participants showed similar levels of vaccine hesitancy to the U.S. However, associations between participant race and ethnicity and levels of vaccine uptake were observed to be different in the U.S. and the U.K. studies. Among U.S. participants, vaccine uptake was significantly lower among Black participants, which persisted among participants that self-reported being vaccine-willing. In contrast, statistically significant racial and ethnic disparities in vaccine uptake were not observed in the U.K sample. In this study of self-reported vaccine hesitancy and uptake, lower levels of vaccine uptake in Black participants in the U.S. during the initial vaccine rollout may be attributable to both hesitancy and disparities in access.", "doi": "10.1038/s41467-022-28200-3", "pmid": "35105869", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-022-28200-3"}], "notes": [], "created": "2022-02-06T16:51:03.679Z", "modified": "2022-02-06T16:51:03.864Z"}, {"entity": "publication", "iuid": "2f8eb9d568d649e398c46824757736cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2f8eb9d568d649e398c46824757736cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2f8eb9d568d649e398c46824757736cc"}}, "title": "Conditionality of COVID-19 vaccine acceptance in European countries.", "authors": [{"family": "Heyerdahl", "given": "Leonardo W", "initials": "LW"}, {"family": "Vray", "given": "Muriel", "initials": "M"}, {"family": "Lana", "given": "Benedetta", "initials": "B"}, {"family": "Tvardik", "given": "Nastassia", "initials": "N"}, {"family": "Gobat", "given": "Nina", "initials": "N"}, {"family": "Wanat", "given": "Marta", "initials": "M"}, {"family": "Tonkin-Crine", "given": "Sarah", "initials": "S"}, {"family": "Anthierens", "given": "Sibyl", "initials": "S"}, {"family": "Goossens", "given": "Herman", "initials": "H"}, {"family": "Giles-Vernick", "given": "Tamara", "initials": "T"}], "type": "journal article", "published": "2022-02-01", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null}, "abstract": "The COVID-19 vaccine rollout has offered a powerful preventive measure to help control SARS-CoV-2 transmission. Nevertheless, long-standing public hesitation around vaccines heightened concerns that vaccine coverage would not achieve desired public health impacts, particularly in light of more contagious variants. This cross-sectional survey was conducted online just before the European vaccine rollout in December 2020 among 7000 respondents (aged 18-65) in Belgium, France, Germany, Italy, Spain, Sweden, and Ukraine. The survey included open text boxes for fuller explanation of responses. Overall, 56.9% of respondents would accept a COVID-19 vaccine, 19.0% would not, and 24.1% did not know or preferred not to say. By country, between 44% (France) and 66% (Italy) of respondents would accept a COVID-19 vaccine. Respondents expressed conditionality in open responses, voicing concerns about vaccine safety and mistrust of authorities. We highlight lessons learned about the dynamism of vaccine conditionality and persistence of safety concerns.", "doi": "10.1016/j.vaccine.2022.01.054", "pmid": "35125225", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(22)00099-8"}], "notes": [], "created": "2022-02-08T15:15:41.099Z", "modified": "2022-02-08T15:15:41.113Z"}, {"entity": "publication", "iuid": "d4948847193e46a89360c70bc03170dc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4948847193e46a89360c70bc03170dc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4948847193e46a89360c70bc03170dc"}}, "title": "Variations in the financial impact of the COVID-19 pandemic across 5 continents: A cross-sectional, individual level analysis.", "authors": [{"family": "Khetan", "given": "Aditya K", "initials": "AK"}, {"family": "Yusuf", "given": "Salim", "initials": "S"}, {"family": "Lopez-Jaramillo", "given": "Patricio", "initials": "P"}, {"family": "Szuba", "given": "Andrzej", "initials": "A"}, {"family": "Orlandini", "given": "Andres", "initials": "A"}, {"family": "Mat-Nasir", "given": "Nafiza", "initials": "N"}, {"family": "Oguz", "given": "Aytekin", "initials": "A"}, {"family": "Gupta", "given": "Rajeev", "initials": "R"}, {"family": "Avezum", "given": "\u00c1lvaro", "initials": "\u00c1"}, {"family": "Rosnah", "given": "Ismail", "initials": "I"}, {"family": "Poirier", "given": "Paul", "initials": "P"}, {"family": "Teo", "given": "Koon K", "initials": "KK"}, {"family": "Wielgosz", "given": "Andreas", "initials": "A"}, {"family": "Lear", "given": "Scott A", "initials": "SA"}, {"family": "Palileo-Villanueva", "given": "Lia M", "initials": "LM"}, {"family": "Ser\u00f3n", "given": "Pamela", "initials": "P"}, {"family": "Chifamba", "given": "Jephat", "initials": "J"}, {"family": "Rangarajan", "given": "Sumathy", "initials": "S"}, {"family": "Mushtaha", "given": "Maha", "initials": "M"}, {"family": "Mohan", "given": "Deepa", "initials": "D"}, {"family": "Yeates", "given": "Karen", "initials": "K"}, {"family": "McKee", "given": "Martin", "initials": "M"}, {"family": "Mony", "given": "Prem K", "initials": "PK"}, {"family": "Walli-Attaei", "given": "Marjan", "initials": "M"}, {"family": "Khansaheb", "given": "Hamda", "initials": "H"}, {"family": "Rosengren", "given": "Annika", "initials": "A"}, {"family": "Alhabib", "given": "Khalid F", "initials": "KF"}, {"family": "Kruger", "given": "Iolanth\u00e9 M", "initials": "IM"}, {"family": "Paucar", "given": "Mar\u00eda-Jos\u00e9", "initials": "MJ"}, {"family": "Mirrakhimov", "given": "Erkin", "initials": "E"}, {"family": "Assembekov", "given": "Batyrbek", "initials": "B"}, {"family": "Leong", "given": "Darryl P", "initials": "DP"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": "44", "pages": "101284", "issn-l": null}, "abstract": "COVID-19 has caused profound socio-economic changes worldwide. However, internationally comparative data regarding the financial impact on individuals is sparse. Therefore, we conducted a survey of the financial impact of the pandemic on individuals, using an international cohort that has been well-characterized prior to the pandemic.\n\nBetween August 2020 and September 2021, we surveyed 24,506 community-dwelling participants from the Prospective Urban-Rural Epidemiology (PURE) study across high (HIC), upper middle (UMIC)-and lower middle (LMIC)-income countries. We collected information regarding the impact of the pandemic on their self-reported personal finances and sources of income.\n\nOverall, 32.4% of participants had suffered an adverse financial impact, defined as job loss, inability to meet financial obligations or essential needs, or using savings to meet financial obligations. 8.4% of participants had lost a job (temporarily or permanently); 14.6% of participants were unable to meet financial obligations or essential needs at the time of the survey and 16.3% were using their savings to meet financial obligations. Participants with a post-secondary education were least likely to be adversely impacted (19.6%), compared with 33.4% of those with secondary education and 33.5% of those with pre-secondary education. Similarly, those in the highest wealth tertile were least likely to be financially impacted (26.7%), compared with 32.5% in the middle tertile and 30.4% in the bottom tertile participants. Compared with HICs, financial impact was greater in UMIC [odds ratio of 2.09 (1.88-2.33)] and greatest in LMIC [odds ratio of 16.88 (14.69-19.39)]. HIC participants with the lowest educational attainment suffered less financial impact (15.1% of participants affected) than those with the highest education in UMIC (22.0% of participants affected). Similarly, participants with the lowest education in UMIC experienced less financial impact (28.3%) than those with the highest education in LMIC (45.9%). A similar gradient was seen across country income categories when compared by pre-pandemic wealth status.\n\nThe financial impact of the pandemic differs more between HIC, UMIC, and LMIC than between socio-economic categories within a country income level. The most disadvantaged socio-economic subgroups in HIC had a lower financial impact from the pandemic than the most advantaged subgroup in UMIC, with a similar disparity seen between UMIC and LMIC. Continued high levels of infection will exacerbate financial inequity between countries and hinder progress towards the sustainable development goals, emphasising the importance of effective measures to control COVID-19 and, especially, ensuring high vaccine coverage in all countries.\n\nFunding for this study was provided by the Canadian Institutes of Health Research and the International Development Research Centre.", "doi": "10.1016/j.eclinm.2022.101284", "pmid": "35106472", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(22)00014-1"}, {"db": "pmc", "key": "PMC8794545"}], "notes": [], "created": "2022-02-06T16:50:23.395Z", "modified": "2022-02-06T16:50:23.408Z"}, {"entity": "publication", "iuid": "cd6a3a5d47334aa6a79c66e514409e4e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd6a3a5d47334aa6a79c66e514409e4e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd6a3a5d47334aa6a79c66e514409e4e"}}, "title": "The benefits, costs and feasibility of a low incidence COVID-19 strategy.", "authors": [{"family": "Czypionka", "given": "Thomas", "initials": "T"}, {"family": "Iftekhar", "given": "Emil N", "initials": "EN"}, {"family": "Prainsack", "given": "Barbara", "initials": "B"}, {"family": "Priesemann", "given": "Viola", "initials": "V"}, {"family": "Bauer", "given": "Simon", "initials": "S"}, {"family": "Calero Valdez", "given": "Andr\u00e9", "initials": "A"}, {"family": "Cuschieri", "given": "Sarah", "initials": "S"}, {"family": "Glaab", "given": "Enrico", "initials": "E"}, {"family": "Grill", "given": "Eva", "initials": "E"}, {"family": "Krutzinna", "given": "Jenny", "initials": "J"}, {"family": "Lionis", "given": "Christos", "initials": "C"}, {"family": "Machado", "given": "Helena", "initials": "H"}, {"family": "Martins", "given": "Carlos", "initials": "C"}, {"family": "Pavlakis", "given": "George N", "initials": "GN"}, {"family": "Perc", "given": "Matja\u017e", "initials": "M"}, {"family": "Petelos", "given": "Elena", "initials": "E"}, {"family": "Pickersgill", "given": "Martyn", "initials": "M"}, {"family": "Skupin", "given": "Alexander", "initials": "A"}, {"family": "Schernhammer", "given": "Eva", "initials": "E"}, {"family": "Szczurek", "given": "Ewa", "initials": "E"}, {"family": "Tsiodras", "given": "Sotirios", "initials": "S"}, {"family": "Willeit", "given": "Peter", "initials": "P"}, {"family": "Wilmes", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "13", "pages": "100294", "issn-l": null}, "abstract": "In the summer of 2021, European governments removed most NPIs after experiencing prolonged second and third waves of the COVID-19 pandemic. Most countries failed to achieve immunization rates high enough to avoid resurgence of the virus. Public health strategies for autumn and winter 2021 have ranged from countries aiming at low incidence by re-introducing NPIs to accepting high incidence levels. However, such high incidence strategies almost certainly lead to the very consequences that they seek to avoid: restrictions that harm people and economies. At high incidence, the important pandemic containment measure 'test-trace-isolate-support' becomes inefficient. At that point, the spread of SARS-CoV-2 and its numerous harmful consequences can likely only be controlled through restrictions. We argue that all European countries need to pursue a low incidence strategy in a coordinated manner. Such an endeavour can only be successful if it is built on open communication and trust.", "doi": "10.1016/j.lanepe.2021.100294", "pmid": "35005678", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00280-5"}, {"db": "pmc", "key": "PMC8720492"}], "notes": [], "created": "2022-01-13T21:09:51.362Z", "modified": "2022-01-13T21:09:51.378Z"}, {"entity": "publication", "iuid": "a36849b91d9f402f973b726bd0da8b38", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a36849b91d9f402f973b726bd0da8b38.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a36849b91d9f402f973b726bd0da8b38"}}, "title": "Risk of infection, hospitalisation, and death up to 9 months after a second dose of COVID-19 vaccine: a retrospective, total population cohort study in Sweden", "authors": [{"family": "Nordstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Ballin", "given": "Marcel", "initials": "M"}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal-article", "published": "2022-02-00", "journal": {"title": "Lancet", "issn": "0140-6736", "issn-l": null}, "abstract": null, "doi": "10.1016/s0140-6736(22)00089-7", "pmid": null, "labels": {"Category: Health": null, "Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-08T15:10:34.563Z", "modified": "2022-02-08T15:10:34.575Z"}, {"entity": "publication", "iuid": "0de9bcdefa794cf0a6b6b4c519a9c53e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0de9bcdefa794cf0a6b6b4c519a9c53e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0de9bcdefa794cf0a6b6b4c519a9c53e"}}, "title": "Quality of facility-based maternal and newborn care around the time of childbirth during the COVID-19 pandemic: online survey investigating maternal perspectives in 12 countries of the WHO European Region.", "authors": [{"family": "Lazzerini", "given": "Marzia", "initials": "M"}, {"family": "Covi", "given": "Benedetta", "initials": "B"}, {"family": "Mariani", "given": "Ilaria", "initials": "I"}, {"family": "Drglin", "given": "Zalka", "initials": "Z"}, {"family": "Arendt", "given": "Maryse", "initials": "M"}, {"family": "Nedberg", "given": "Ingvild Hersoug", "initials": "IH"}, {"family": "Elden", "given": "Helen", "initials": "H"}, {"family": "Costa", "given": "Raquel", "initials": "R"}, {"family": "Drandi\u0107", "given": "Daniela", "initials": "D"}, {"family": "Radeti\u0107", "given": "Jelena", "initials": "J"}, {"family": "Otelea", "given": "Marina Ruxandra", "initials": "MR"}, {"family": "Miani", "given": "C\u00e9line", "initials": "C"}, {"family": "Brigidi", "given": "Serena", "initials": "S"}, {"family": "Roz\u00e9e", "given": "Virginie", "initials": "V"}, {"family": "Ponikvar", "given": "Barbara Mihevc", "initials": "BM"}, {"family": "Tasch", "given": "Barbara", "initials": "B"}, {"family": "Kongslien", "given": "Sigrun", "initials": "S"}, {"family": "Linden", "given": "Karolina", "initials": "K"}, {"family": "Barata", "given": "Catarina", "initials": "C"}, {"family": "Kurbanovi\u0107", "given": "Magdalena", "initials": "M"}, {"family": "Ru\u017ei\u010di\u0107", "given": "Jovana", "initials": "J"}, {"family": "Batram-Zantvoort", "given": "Stephanie", "initials": "S"}, {"family": "Casta\u00f1eda", "given": "Lara Mart\u00edn", "initials": "LM"}, {"family": "Rochebrochard", "given": "Elise de La", "initials": "E"}, {"family": "Bohinec", "given": "Anja", "initials": "A"}, {"family": "Vik", "given": "Eline Skirnisdottir", "initials": "ES"}, {"family": "Zaigham", "given": "Mehreen", "initials": "M"}, {"family": "Santos", "given": "Teresa", "initials": "T"}, {"family": "Wandschneider", "given": "Lisa", "initials": "L"}, {"family": "Viver", "given": "Ana Canales", "initials": "AC"}, {"family": "\u0106erimagi\u0107", "given": "Amira", "initials": "A"}, {"family": "Sacks", "given": "Emma", "initials": "E"}, {"family": "Valente", "given": "Emanuelle Pessa", "initials": "EP"}, {"family": "IMAgiNE EURO study group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "13", "pages": "100268", "issn-l": null}, "abstract": "Multi-country studies assessing the quality of maternal and newborn care (QMNC) during the COVID-19 pandemic, as defined by WHO Standards, are lacking.\n\nWomen who gave birth in 12 countries of the WHO European Region from March 1, 2020 - March 15, 2021 answered an online questionnaire, including 40 WHO Standard-based Quality Measures.\n\n21,027 mothers were included in the analysis. Among those who experienced labour (N=18,063), 41\u00b78% (26\u00b71%- 63\u00b75%) experienced difficulties in accessing antenatal care, 62% (12\u00b76%-99\u00b70%) were not allowed a companion of choice, 31\u00b71% (16\u00b75%-56\u00b79%) received inadequate breastfeeding support, 34\u00b74% (5\u00b72%-64\u00b78%) reported that health workers were not always using protective personal equipment, and 31\u00b78% (17\u00b78%-53\u00b71%) rated the health workers' number as \"insufficient\". Episiotomy was performed in 20\u00b71% (6\u00b71%-66\u00b70%) of spontaneous vaginal births and fundal pressure applied in 41\u00b72% (11\u00b75% -100%) of instrumental vaginal births. In addition, 23\u00b79% women felt they were not treated with dignity (12\u00b78%-59\u00b78%), 12\u00b75% (7\u00b70%-23\u00b74%) suffered abuse, and 2\u00b74% (0\u00b71%-26\u00b72%) made informal payments. Most findings were significantly worse among women with prelabour caesarean birth (N=2,964). Multivariate analyses confirmed significant differences among countries, with Croatia, Romania, Serbia showing significant lower QMNC Indexes and Luxemburg showing a significantly higher QMNC Index than the total sample. Younger women and those with operative births also reported significantly lower QMNC Indexes.\n\nMothers reports revealed large inequities in QMNC across countries of the WHO European Region. Quality improvement initiatives to reduce these inequities and promote evidence-based, patient-centred respectful care for all mothers and newborns during the COVID-19 pandemic and beyond are urgently needed.\n\nThe study was financially supported by the Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy.\n\nClinicalTrials.gov Identifier: NCT04847336.", "doi": "10.1016/j.lanepe.2021.100268", "pmid": "34977838", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00254-4"}, {"db": "pmc", "key": "PMC8703114"}, {"db": "ClinicalTrials.gov", "key": "NCT04847336"}], "notes": [], "created": "2022-01-04T14:44:07.308Z", "modified": "2022-01-04T14:44:07.321Z"}, {"entity": "publication", "iuid": "c5f19e306adb4417b8cf7ec7c7f08643", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5f19e306adb4417b8cf7ec7c7f08643.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5f19e306adb4417b8cf7ec7c7f08643"}}, "title": "Mortality in hospitalized COVID-19 patients was associated with the COVID-19 admission rate during the first year of the pandemic in Sweden.", "authors": [{"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Wahlstr\u00f6m", "given": "Erik", "initials": "E"}, {"family": "Walther", "given": "Sten", "initials": "S"}, {"family": "Bennet-Bark", "given": "Anna M", "initials": "AM"}, {"family": "Heurgren", "given": "Mona", "initials": "M"}, {"family": "Lind\u00e9n", "given": "Thomas", "initials": "T"}, {"family": "Holm", "given": "Johanna", "initials": "J"}, {"family": "Hanberger", "given": "H\u00e5kan", "initials": "H"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "pages": "145-151", "volume": "54", "issue": "2", "issn-l": "2374-4235"}, "abstract": "Studies from the first pandemic wave found associations between COVID-19 hospital load and mortality. Here, we aimed to study if mortality of hospitalized COVID-19 patients was associated with the COVID-19 admission rate during a full year of the pandemic in Sweden.\n\nObservational review of all patients admitted to hospital with COVID-19 in Sweden between March 2020 and February 2021 (n = 42,017). Primary outcome was 60-day all-cause mortality related to number of COVID-19 hospital admissions per month/100,000 inhabitants. Poisson regression was used to estimate the relative risk for death by month of admission, adjusting for pre-existing factors.\n\nThe overall mortality was 17.4%. Excluding March 2020, mortality was clearly correlated to the number of COVID-19 admissions per month (coefficient of correlation \u03c1=.96; p<.0001). After adjustment for pre-existing factors, the correlation remained significant (\u03c1=.75, p=.02). Patients admitted in December (high admission rate and high mortality) had more comorbidities and longer hospital stays, and patients treated in intensive care units (ICU) had longer pre-ICU hospital stays and worse respiratory status on ICU admission than those admitted in July to September (low admission rate and low mortality).\n\nMortality in hospitalized COVID-19 patients was clearly associated with the COVID-19 admission rate. Admission of healthier patients between pandemic waves and delayed ICU care during wave peaks could contribute to this pattern. The study supports measures to flatten-the-curve to reduce the number of COVID-19 patients admitted to hospital.", "doi": "10.1080/23744235.2021.1983643", "pmid": "34612774", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:27:15.805Z", "modified": "2023-01-13T13:34:39.945Z"}, {"entity": "publication", "iuid": "c37b19480dee4ac5929dad2316314ed8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c37b19480dee4ac5929dad2316314ed8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c37b19480dee4ac5929dad2316314ed8"}}, "title": "Mortality in Norway and Sweden during the COVID-19 pandemic.", "authors": [{"family": "Juul", "given": "Frederik E", "initials": "FE", "orcid": "0000-0003-3317-6988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4523958ae7f845afa749e7925890d292.json"}}, {"family": "Jodal", "given": "Henriette C", "initials": "HC", "orcid": "0000-0001-6957-9469", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6700190f6094980bc6542652f2aa833.json"}}, {"family": "Barua", "given": "Ishita", "initials": "I"}, {"family": "Refsum", "given": "Erle", "initials": "E"}, {"family": "Olsvik", "given": "\u00d8rjan", "initials": "\u00d8"}, {"family": "Helsingen", "given": "Lise M", "initials": "LM"}, {"family": "L\u00f8berg", "given": "Magnus", "initials": "M"}, {"family": "Bretthauer", "given": "Michael", "initials": "M"}, {"family": "Kalager", "given": "Mette", "initials": "M"}, {"family": "Emilsson", "given": "Louise", "initials": "L"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "38-45", "volume": "50", "issue": "1", "issn-l": "1403-4948"}, "abstract": "Background: Norway and Sweden are similar countries in terms of socioeconomics and health care. Norway implemented extensive COVID-19 measures, such as school closures and lockdowns, whereas Sweden did not. Aims: To compare mortality in Norway and Sweden, two similar countries with very different mitigation measures against COVID-19. Methods: Using real-world data from national registries, we compared all-cause and COVID-19-related mortality rates with 95% confidence intervals (CI) per 100,000 person-weeks and mortality rate ratios (MRR) comparing the five preceding years (2015-2019) with the pandemic year (2020) in Norway and Sweden. Results: In Norway, all-cause mortality was stable from 2015 to 2019 (mortality rate 14.6-15.1 per 100,000 person-weeks; mean mortality rate 14.9) and was lower in 2020 than from 2015 to 2019 (mortality rate 14.4; MRR 0.97; 95% CI 0.96-0.98). In Sweden, all-cause mortality was stable from 2015 to 2018 (mortality rate 17.0-17.8; mean mortality rate 17.1) and similar to that in 2020 (mortality rate 17.6), but lower in 2019 (mortality rate 16.2). Compared with the years 2015-2019, all-cause mortality in the pandemic year was 3% higher due to the lower rate in 2019 (MRR 1.03; 95% CI 1.02-1.04). Excess mortality was confined to people aged \u2a7e70 years in Sweden compared with previous years. The COVID-19-associated mortality rates per 100,000 person-weeks during the first wave of the pandemic were 0.3 in Norway and 2.9 in Sweden. Conclusions: All-cause mortality in 2020 decreased in Norway and increased in Sweden compared with previous years. The observed excess deaths in Sweden during the pandemic may, in part, be explained by mortality displacement due to the low all-cause mortality in the previous year.", "doi": "10.1177/14034948211047137", "pmid": "34609261", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8807990"}], "notes": [], "created": "2021-10-10T15:29:25.585Z", "modified": "2023-07-13T11:29:07.186Z"}, {"entity": "publication", "iuid": "952cfb24d67248238d32e5d03d5a3116", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/952cfb24d67248238d32e5d03d5a3116.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/952cfb24d67248238d32e5d03d5a3116"}}, "title": "Mining user reviews of COVID contact-tracing apps: An exploratory analysis of nine European apps.", "authors": [{"family": "Garousi", "given": "Vahid", "initials": "V"}, {"family": "Cutting", "given": "David", "initials": "D"}, {"family": "Felderer", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "J Syst Softw", "issn": "0164-1212", "volume": "184", "pages": "111136", "issn-l": null}, "abstract": "More than 78 countries have developed COVID contact-tracing apps to limit the spread of coronavirus. However, many experts and scientists cast doubt on the effectiveness of those apps. For each app, a large number of reviews have been entered by end-users in app stores.\n\nOur goal is to gain insights into the user reviews of those apps, and to find out the main problems that users have reported. Our focus is to assess the \"software in society\" aspects of the apps, based on user reviews.\n\nWe selected nine European national apps for our analysis and used a commercial app-review analytics tool to extract and mine the user reviews. For all the apps combined, our dataset includes 39,425 user reviews.\n\nResults show that users are generally dissatisfied with the nine apps under study, except the Scottish (\"Protect Scotland\") app. Some of the major issues that users have complained about are high battery drainage and doubts on whether apps are really working.\n\nOur results show that more work is needed by the stakeholders behind the apps (e.g., app developers, decision-makers, public health experts) to improve the public adoption, software quality and public perception of these apps.", "doi": "10.1016/j.jss.2021.111136", "pmid": "34751198", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0164-1212(21)00233-8"}, {"db": "pmc", "key": "PMC8566091"}], "notes": [], "created": "2021-11-26T15:24:59.824Z", "modified": "2021-11-26T15:24:59.858Z"}, {"entity": "publication", "iuid": "112f72343b48421da285c080bad59e9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/112f72343b48421da285c080bad59e9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/112f72343b48421da285c080bad59e9c"}}, "title": "Intensive care-treated COVID-19 patients' perception of their illness and remaining symptoms.", "authors": [{"family": "Wallin", "given": "Ewa", "initials": "E", "orcid": "0000-0003-2492-8666", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9dce246ac6b4c178c7556613294dd2b.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Rubertsson", "given": "Sten", "initials": "S"}, {"family": "Larsson", "given": "Ing-Marie", "initials": "I"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": "66", "issue": "2", "pages": "240-247"}, "abstract": "The remaining symptoms in patients with coronavirus disease 2019 (COVID-19) treated in intensive care unit are limited described. Therefore, we assessed patient's perception of their COVID-19 disease, stay in intensive care, and remaining symptoms three to six months after intensive care.\r\n\r\nProspective cohort study was performed in one intensive care unit of a university hospital in Sweden during the first wave. A questionnaire with open-ended questions and closed-ended questions was used. Data were analyzed using qualitative and quantitative content analysis and descriptive statistics.\r\n\r\nOut of 123 patients treated for COVID-19, 64 answered the questionnaire 3-6 months after discharge from intensive care. Memories from illness and hospital stay revealed in three categories; awareness of the illness, losing anchor to reality and being cared for in a dynamic environment. Information was perceived as spare by 48% and they wanted the information to be more personal. The diary was perceived as personal and was received by 33% patients. The relationship with family was affected among 39% and 13% of the patients indicated that they had not resumed their daily life. A large amount, 84%, indicated that they had remaining symptoms from COVID-19. The dominated symptoms were impaired strength and energy both physically and mentally.\r\n\r\nPatients reported a variety of physical and mental symptoms, and revealed memories from the ICU, and specific awareness of other patients' health. It illustrates the need for screening patients for remaining symptoms after COVID-19 disease and ICU care and may affect resuming patients' daily life.", "doi": "10.1111/aas.13992", "pmid": "34704256", "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pmc", "key": "PMC8653095"}], "notes": [], "created": "2021-11-01T19:42:20.654Z", "modified": "2022-02-08T19:16:01.129Z"}, {"entity": "publication", "iuid": "cfacc9763ebf480ab738d5d9b4caa532", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfacc9763ebf480ab738d5d9b4caa532.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfacc9763ebf480ab738d5d9b4caa532"}}, "title": "How children in Sweden accessed and perceived information during the first phase of the Covid-19 pandemic.", "authors": [{"family": "Rydstr\u00f6m", "given": "Lise-Lott", "initials": "LL", "orcid": "0000-0002-1007-1959", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad5251de283d4f73b0c2ac600a34a19a.json"}}, {"family": "\u00c5ngstr\u00f6m-Br\u00e4nnstr\u00f6m", "given": "Charlotte", "initials": "C"}, {"family": "Blake", "given": "Lucy", "initials": "L"}, {"family": "Brayl", "given": "Lucy", "initials": "L"}, {"family": "Carter", "given": "Bernie", "initials": "B"}, {"family": "Forsner", "given": "Maria", "initials": "M"}, {"family": "Matsson", "given": "Janet", "initials": "J"}, {"family": "Nilsson", "given": "Stefan", "initials": "S"}, {"family": "Jenholt Nolbris", "given": "Margaretha", "initials": "M", "orcid": "0000-0002-6911-1484", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f53d9c5dc5ff46149ef63e16dfa6d7a1.json"}}, {"family": "Kirton", "given": "Jennifer", "initials": "J"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "Protheroe", "given": "Joanne", "initials": "J"}, {"family": "Rullander", "given": "Anna-Clara", "initials": "AC"}, {"family": "Saron", "given": "Holly", "initials": "H"}, {"family": "Lindholm Olinder", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "144-151", "volume": "50", "issue": "1", "issn-l": "1403-4948"}, "abstract": "To describe how children in Sweden accessed and perceived information about SARS-CoV2 and Covid-19 during the first phase of the outbreak.\n\nThis study is a substudy of an international cross-sectional online mixed methods survey examining elements of children's health literacy in relation to Covid-19. The survey included multiple-choice questions, open-ended questions and drawings and collected information from 50 Swedish children (7-12 years). Data were analysed concurrently on a descriptive level using statistics and content analysis. Quantitative and qualitative data, including the drawings, were considered equally important and resulted in six categories, illuminating how children accessed and perceived information about the pandemic.\n\nThe survey showed that children accessed information mainly from school but also from TV. They preferred information from reliable sources. Children reported the information they accessed as easy to understand and it prompted them to ask new questions. They reported they knew a lot about the pandemic, for example, the potential danger to themselves and others and how to act to protect themselves and others. They perceived the pandemic as an intrusion on their lives.\n\nThis study indicates that Swedish children between 7 and 12 years old were well informed about SARS-CoV2 and Covid-19 during the first phase of the pandemic. School was shown to be an important source of information. The children could explain how to act to protect themselves and others from becoming infected by the virus.", "doi": "10.1177/14034948211051884", "pmid": "34736348", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8807992"}], "notes": [], "created": "2021-11-08T09:16:39.380Z", "modified": "2023-01-13T13:51:41.582Z"}, {"entity": "publication", "iuid": "60ee8787609f4c53af2c09abcf3a14a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60ee8787609f4c53af2c09abcf3a14a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60ee8787609f4c53af2c09abcf3a14a0"}}, "title": "Effects of the COVID-19 pandemic on the mental health of seafarers: A comparison using matched samples.", "authors": [{"family": "Pauksztat", "given": "Birgit", "initials": "B"}, {"family": "Andrei", "given": "Daniela M", "initials": "DM"}, {"family": "Grech", "given": "Michelle R", "initials": "MR"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Saf Sci", "issn": "0925-7535", "volume": "146", "pages": "105542", "issn-l": null}, "abstract": "The COVID-19 pandemic and the measures implemented to curb its transmission have altered workplaces and challenged occupational health and safety in unprecedented ways, with high levels of mental distress reported across several industries. In the maritime industry, occupational health and safety risks, including psychosocial risks, were a concern already before the COVID-19 pandemic. However, knowledge about the prevalence of mental health problems and the factors associated with them is still limited. The purpose of this study was to investigate the impact of the COVID-19 pandemic as well as the effects of respondent and work-related characteristics on seafarers' self-reported symptoms of depression and anxiety. Data came from two cross-sectional convenience samples of seafarers on international commercial vessels, surveyed before (Npre-pandemic = 793) and during the pandemic (Npandemic = 504). Matching the two samples on respondent and work-related characteristics using propensity scores, we found that the pandemic contributed to significantly higher levels of depression and anxiety. Further analyses showed that seafarers with longer work periods, those who had been on board longer than expected, and those working on vessels registered with \"Flags of Convenience\" reported significantly higher levels of both depression and anxiety during the pandemic, but not prior to the pandemic. Taken together, these findings suggest that the impact of the COVID-19 pandemic led to a deterioration of working conditions and increased mental health risks for seafarers. Practical implications for safe-guarding occupational health and safety during this and future crises are discussed.", "doi": "10.1016/j.ssci.2021.105542", "pmid": "34744311", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0925-7535(21)00385-4"}, {"db": "pmc", "key": "PMC8556536"}], "notes": [], "created": "2021-11-26T15:36:01.988Z", "modified": "2021-11-26T15:36:02.000Z"}, {"entity": "publication", "iuid": "bbd1f4a00548411baa09980def7774e3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bbd1f4a00548411baa09980def7774e3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bbd1f4a00548411baa09980def7774e3"}}, "title": "Digital communities of practice: one step towards decolonising global health partnerships.", "authors": [{"family": "Sant Fruchtman", "given": "Carmen", "initials": "C", "orcid": "0000-0002-5276-3515", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a71c19d528084816a975a3df84a7e2bc.json"}}, {"family": "Bilal Khalid", "given": "Muhammad", "initials": "M", "orcid": "0000-0003-3986-7093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5037eaca65284f5cad172d462853272d.json"}}, {"family": "Keakabetse", "given": "Tshiamo", "initials": "T", "orcid": "0000-0003-0725-0961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2309f59fae34a388d346452b97f78e5.json"}}, {"family": "Bonito", "given": "Antonio", "initials": "A"}, {"family": "Saulnier", "given": "Dell D", "initials": "DD", "orcid": "0000-0001-7761-0737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d3fc961101845b1ae844339af7495e4.json"}}, {"family": "Mupara", "given": "Lucia Mungapeyi", "initials": "LM", "orcid": "0000-0003-3497-624X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea507bc1ee1248ceb82868ff1d30fa81.json"}}, {"family": "Iqbal", "given": "Shahid", "initials": "S", "orcid": "0000-0002-9211-1212", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b0e092055ca4eb395503bb02161ef31.json"}}, {"family": "de Almeida", "given": "Afonso", "initials": "A"}, {"family": "da Silva", "given": "Hendriketa", "initials": "H"}, {"family": "de Jesus", "given": "Diamantino", "initials": "D"}, {"family": "Prytherch", "given": "Helen", "initials": "H"}, {"family": "Mokalake", "given": "Ellen", "initials": "E"}, {"family": "Cobos Mu\u00f1oz", "given": "Daniel", "initials": "D", "orcid": "0000-0002-5920-1304", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89b7c57ce7304d659ec7a077a0a841dc.json"}}, {"family": "Zafar", "given": "Shamsa", "initials": "S", "orcid": "0000-0003-4397-5505", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/880e602fe5c64b8182e075f1f17caa8c.json"}}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "7", "issue": "2", "issn-l": "2059-7908"}, "abstract": null, "doi": "10.1136/bmjgh-2021-008174", "pmid": "35110274", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-008174"}], "notes": [], "created": "2022-02-06T16:49:54.389Z", "modified": "2022-02-06T16:49:54.650Z"}, {"entity": "publication", "iuid": "a3ed4c5b77514da0a2a847afe8a47040", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3ed4c5b77514da0a2a847afe8a47040.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3ed4c5b77514da0a2a847afe8a47040"}}, "title": "Dataset: COVID-19 epidemic policy and events timeline (Sweden).", "authors": [{"family": "Olofsson", "given": "Tobias", "initials": "T"}, {"family": "Vilhelmsson", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Data Brief", "issn": "2352-3409", "volume": "40", "pages": "107698", "issn-l": null}, "abstract": "The Swedish approach to managing the 2020-2021 COVID-19 pandemic has received significant attention in international scholarly work and press. For this dataset, we have reviewed governmental and media archives to build a detailed timeline that chronicles significant policies, interventions, and events in the Swedish management of COVID-19. The dataset contains summary descriptions of what took place, when it happened, and who the principal actors involved were. Links to primary sources are provided for each entry. Because of the level of detail and saturation, the dataset offers a detailed account of Swedish pandemic governance and will benefit anyone working on Swedish pandemic management or doing comparative work between Sweden and other jurisdictions.", "doi": "10.1016/j.dib.2021.107698", "pmid": "34926743", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2352-3409(21)00973-2"}, {"db": "pmc", "key": "PMC8667349"}, {"db": "URL", "key": "https://doi.org/10.5281/zenodo.5718433", "description": "https://doi.org/10.5281/zenodo.5718433"}], "notes": [], "created": "2022-01-03T15:24:42.157Z", "modified": "2022-01-03T15:25:34.875Z"}, {"entity": "publication", "iuid": "47860632a9a641bc8cfc1e7a85fb5e30", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47860632a9a641bc8cfc1e7a85fb5e30.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47860632a9a641bc8cfc1e7a85fb5e30"}}, "title": "Compliance with recommendations limiting COVID-19 contagion among university students in Sweden: associations with self-reported symptoms, mental health and academic self-efficacy.", "authors": [{"family": "Berman", "given": "Anne H", "initials": "AH", "orcid": "0000-0002-7709-0230", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c6d87ccfe79452d920ffbe797143f38.json"}}, {"family": "Bendtsen", "given": "Marcus", "initials": "M"}, {"family": "Molander", "given": "Olof", "initials": "O"}, {"family": "Lindfors", "given": "Petra", "initials": "P"}, {"family": "Lindner", "given": "Philip", "initials": "P"}, {"family": "Granlund", "given": "Lilian", "initials": "L"}, {"family": "Topooco", "given": "Naira", "initials": "N"}, {"family": "Engstr\u00f6m", "given": "Karin", "initials": "K"}, {"family": "Andersson", "given": "Claes", "initials": "C"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": "50", "issue": "1", "pages": "70-84"}, "abstract": "The COVID-19 containment strategy in Sweden uses public health recommendations relying on personal responsibility for compliance. Universities were one of few public institutions subject to strict closure, meaning that students had to adapt overnight to online teaching. This study investigates the prevalence of self-reported recommendation compliance and associations with self-reported symptoms of contagion, self-experienced effects on mental health and academic self-efficacy among university students in Sweden in May-June 2020.\n\nThis was a cross-sectional 23 question online survey in which data were analysed by multinomial regression, taking a Bayesian analysis approach complemented by null hypothesis testing.\n\nA total of 4495 students consented to respond. Recommendation compliance ranged between 70% and 96%. Women and older students reported higher compliance than did men and younger students. Mild to moderate COVID-19 symptoms were reported by 30%, severe symptoms by fewer than 2%; 15% reported being uncertain and half of the participants reported no symptoms. Mental health effects were reported by over 80%, and changes in academic self-efficacy were reported by over 85%; in both these areas negative effects predominated. Self-reported symptoms and uncertainty about contagion were associated with non-compliance, negative mental health effects, and impaired academic self-efficacy.\n\nStudents generally followed public health recommendations during strict closure of universities, but many reported considerable negative consequences related to mental health and academic self-efficacy. Digital interventions should be developed and evaluated to boost coping skills, build resilience and alleviate student suffering during the pandemic and future similar crises.", "doi": "10.1177/14034948211027824", "pmid": "34213359", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8808007"}], "notes": [], "created": "2021-07-05T15:00:03.045Z", "modified": "2023-06-19T14:25:17.882Z"}, {"entity": "publication", "iuid": "c1f1248fa5f24349b1f8e426ec55841b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1f1248fa5f24349b1f8e426ec55841b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1f1248fa5f24349b1f8e426ec55841b"}}, "title": "Co-circulation of SARS-CoV-2 Alpha and Gamma variants in Italy, February and March 2021.", "authors": [{"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Trentini", "given": "Filippo", "initials": "F"}, {"family": "Guzzetta", "given": "Giorgio", "initials": "G"}, {"family": "Marziano", "given": "Valentina", "initials": "V"}, {"family": "Mammone", "given": "Alessia", "initials": "A"}, {"family": "Sane Schepisi", "given": "Monica", "initials": "M"}, {"family": "Poletti", "given": "Piero", "initials": "P"}, {"family": "Molina Gran\u00e9", "given": "Carla", "initials": "C"}, {"family": "Manica", "given": "Mattia", "initials": "M"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Ajelli", "given": "Marco", "initials": "M"}, {"family": "Rezza", "given": "Giovanni", "initials": "G"}, {"family": "Brusaferro", "given": "Silvio", "initials": "S"}, {"family": "Merler", "given": "Stefano", "initials": "S"}, {"family": "COVID-19 National Microbiology Surveillance Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "27", "issue": "5", "issn-l": null}, "abstract": "BackgroundSeveral SARS-CoV-2 variants of concern (VOC) have emerged through 2020 and 2021. There is need for tools to estimate the relative transmissibility of emerging variants of SARS-CoV-2 with respect to circulating strains.AimWe aimed to assess the prevalence of co-circulating VOC in Italy and estimate their relative transmissibility.MethodsWe conducted two genomic surveillance surveys on 18 February and 18 March 2021 across the whole Italian territory covering 3,243 clinical samples and developed a mathematical model that describes the dynamics of co-circulating strains.ResultsThe Alpha variant was already dominant on 18 February in a majority of regions/autonomous provinces (national prevalence: 54%) and almost completely replaced historical lineages by 18 March (dominant across Italy, national prevalence: 86%). We found a substantial proportion of the Gamma variant on 18 February, almost exclusively in central Italy (prevalence: 19%), which remained similar on 18 March. Nationally, the mean relative transmissibility of Alpha ranged at 1.55-1.57 times the level of historical lineages (95% CrI: 1.45-1.66). The relative transmissibility of Gamma varied according to the assumed degree of cross-protection from infection with other lineages and ranged from 1.12 (95% CrI: 1.03-1.23) with complete immune evasion to 1.39 (95% CrI: 1.26-1.56) for complete cross-protection.ConclusionWe assessed the relative advantage of competing viral strains, using a mathematical model assuming different degrees of cross-protection. We found substantial co-circulation of Alpha and Gamma in Italy. Gamma was not able to outcompete Alpha, probably because of its lower transmissibility.", "doi": "10.2807/1560-7917.ES.2022.27.5.2100429", "pmid": "35115077", "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-06T16:47:07.921Z", "modified": "2022-02-06T16:47:07.934Z"}, {"entity": "publication", "iuid": "657c84fe12664bbcb560de7d0549c6b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/657c84fe12664bbcb560de7d0549c6b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/657c84fe12664bbcb560de7d0549c6b2"}}, "title": "Clinical phenotypes and outcomes of SARS-CoV-2, influenza, RSV and seven other respiratory viruses: a retrospective study using complete hospital data.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P", "orcid": "0000-0003-3153-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd6af5accfc84ff9a81983a5ab6683aa.json"}}, {"family": "Karlsson Valik", "given": "John", "initials": "J"}, {"family": "van der Werff", "given": "Suzanne", "initials": "S"}, {"family": "Tanushi", "given": "Hideyuki", "initials": "H"}, {"family": "Requena Mendez", "given": "Ana", "initials": "A"}, {"family": "Granath", "given": "Fredrik", "initials": "F"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}, {"family": "Dyrdak", "given": "Robert", "initials": "R"}, {"family": "Hertting", "given": "Olof", "initials": "O"}, {"family": "F\u00e4rnert", "given": "Anna", "initials": "A"}, {"family": "Ternhag", "given": "Anders", "initials": "A"}, {"family": "Naucler", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Thorax", "issn": "1468-3296", "volume": "77", "issue": "2", "pages": "154-163", "issn-l": null}, "abstract": "An understanding of differences in clinical phenotypes and outcomes COVID-19 compared with other respiratory viral infections is important to optimise the management of patients and plan healthcare. Herein we sought to investigate such differences in patients positive for SARS-CoV-2 compared with influenza, respiratory syncytial virus (RSV) and other respiratory viruses.\n\nWe performed a retrospective cohort study of hospitalised adults and children (\u226415 years) who tested positive for SARS-CoV-2, influenza virus A/B, RSV, rhinovirus, enterovirus, parainfluenza viruses, metapneumovirus, seasonal coronaviruses, adenovirus or bocavirus in a respiratory sample at admission between 2011 and 2020.\n\nA total of 6321 adult (1721 SARS-CoV-2) and 6379 paediatric (101 SARS-CoV-2) healthcare episodes were included in the study. In adults, SARS-CoV-2 positivity was independently associated with younger age, male sex, overweight/obesity, diabetes and hypertension, tachypnoea as well as better haemodynamic measurements, white cell count, platelet count and creatinine values. Furthermore, SARS-CoV-2 was associated with higher 30-day mortality as compared with influenza (adjusted HR (aHR) 4.43, 95% CI 3.51 to 5.59), RSV (aHR 3.81, 95% CI 2.72 to 5.34) and other respiratory viruses (aHR 3.46, 95% CI 2.61 to 4.60), as well as higher 90-day mortality, ICU admission, ICU mortality and pulmonary embolism in adults. In children, patients with SARS-CoV-2 were older and had lower prevalence of chronic cardiac and respiratory diseases compared with other viruses.\n\nSARS-CoV-2 is associated with more severe outcomes compared with other respiratory viruses, and although associated with specific patient and clinical characteristics at admission, a substantial overlap precludes discrimination based on these characteristics.", "doi": "10.1136/thoraxjnl-2021-216949", "pmid": "34226206", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8260304"}, {"db": "pii", "key": "thoraxjnl-2021-216949"}], "notes": [], "created": "2021-08-06T08:46:41.794Z", "modified": "2023-06-19T14:44:08.102Z"}, {"entity": "publication", "iuid": "c7700ea76af04c2587f6db8b1e4cb614", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7700ea76af04c2587f6db8b1e4cb614.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7700ea76af04c2587f6db8b1e4cb614"}}, "title": "Can field botany be effectively taught as a distance course? Experiences and reflections from the COVID-19 pandemic.", "authors": [{"family": "Auffret", "given": "Alistair G", "initials": "AG"}, {"family": "Ekholm", "given": "Adam", "initials": "A"}, {"family": "H\u00e4m\u00e4l\u00e4inen", "given": "Aino", "initials": "A"}, {"family": "Jonsell", "given": "Mats", "initials": "M"}, {"family": "Lehto", "given": "Carl", "initials": "C"}, {"family": "Nordkvist", "given": "Michelle", "initials": "M"}, {"family": "\u00d6ckinger", "given": "Erik", "initials": "E"}, {"family": "Torstensson", "given": "Peter", "initials": "P"}, {"family": "Viketoft", "given": "Maria", "initials": "M"}, {"family": "Thor", "given": "G\u00f6ran", "initials": "G"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "AoB Plants", "issn": "2041-2851", "volume": "14", "issue": "1", "pages": "plab079", "issn-l": null}, "abstract": "The COVID-19 pandemic that started in 2020 forced a rapid change in university teaching, with large numbers of courses switching to distance learning with very little time for preparation. Courses involving many practical elements and field excursions required particular care if students were to fulfil planned learning outcomes. Here, we present our experiences in teaching field botany in 2020 and 2021. Using a range of methods and tools to introduce students to the subject, promote self-learning and reflection and give rapid and regular feedback, we were able to produce a course that allowed students to achieve the intended learning outcomes and that obtained similarly positive student evaluations to previous years. The course and its outcomes were further improved in 2021. We describe how we structured field botany as a distance course in order that we could give the best possible learning experience for the students. Finally, we reflect on how digital tools can aid teaching such subjects in the future, in a world where public knowledge of natural history is declining.", "doi": "10.1093/aobpla/plab079", "pmid": "35035870", "labels": {"Topics: Register-based research": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "plab079"}, {"db": "pmc", "key": "PMC8757578"}], "notes": [], "created": "2022-01-27T07:40:01.555Z", "modified": "2022-01-27T07:40:01.591Z"}, {"entity": "publication", "iuid": "dc69051024a24f44a2ef332f63c87a44", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dc69051024a24f44a2ef332f63c87a44.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dc69051024a24f44a2ef332f63c87a44"}}, "title": "COVID-19 among young adults in Sweden: self-reported long-term symptoms and associated factors.", "authors": [{"family": "Ekstr\u00f6m", "given": "Sandra", "initials": "S", "orcid": "0000-0002-2060-8190", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d63bc101e23740dcae35eefe950ca767.json"}}, {"family": "Andersson", "given": "Niklas", "initials": "N"}, {"family": "L\u00f6vquist", "given": "Alexandra", "initials": "A"}, {"family": "Lauber", "given": "Andr\u00e9", "initials": "A"}, {"family": "Georgelis", "given": "Antonios", "initials": "A"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E", "orcid": "0000-0002-8248-0663", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58e96082947e4752a23f322e42754097.json"}}, {"family": "Bergstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "85-93", "volume": "50", "issue": "1", "issn-l": "1403-4948"}, "abstract": "The main aim of the study was to describe self-reported symptoms of COVID-19 and examine if long-term symptoms are associated with lifestyle factors or common chronic diseases among Swedish young adults. A secondary aim was to compare the prevalence of smoking and snuff use before and during the COVID-19 pandemic.\n\nThe study population includes 1644 participants aged 23-26 years from the Swedish population-based birth cohort BAMSE. From August to November 2020, the participants answered a web questionnaire on COVID-19 symptoms, lifestyle and health. Information on tobacco use was compared against the previous study follow-up in 2016-2019.\n\nThe prevalence of suspected COVID-19 symptoms was 45.3% (n=742), and 80 of these (10.8%) reported long-term symptoms (\u2a7e4 weeks). There was no significant difference in sociodemographic or lifestyle factors in relation to the duration of suspected COVID-19 symptoms. Rhinitis, migraine and lower self-rated health before the pandemic was more common among participants with long-term symptoms. In addition, there was a tendency for higher prevalences of asthma, chronic bronchitis and depression in this group. The prevalence of smoking decreased from 18.9% before the pandemic to 14.7% during the pandemic, while snuff use increased from 12.7% to 22.4% (P<0.001).\n\nAlmost half of Swedish young adults have had symptoms of suspected COVID-19 from February up to August 2020. Among these, one out of 10 have had long-term symptoms for at least 4 weeks. Long-term symptoms of suspected COVID-19 were associated with several common chronic conditions. Smoking may have decreased during the pandemic, while snuff use may have increased.", "doi": "10.1177/14034948211025425", "pmid": "34148461", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8808012"}], "notes": [], "created": "2021-06-28T18:26:14.483Z", "modified": "2023-01-13T13:27:23.137Z"}, {"entity": "publication", "iuid": "5ece2c02daa34aa399d877bf9a35a88e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5ece2c02daa34aa399d877bf9a35a88e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5ece2c02daa34aa399d877bf9a35a88e"}}, "title": "A systems analysis of the COVID-19 pandemic response in the United Kingdom - Part 1 - The overall context.", "authors": [{"family": "Slater", "given": "David", "initials": "D"}, {"family": "Hollnagel", "given": "Erik", "initials": "E"}, {"family": "MacKinnon", "given": "Ralph", "initials": "R"}, {"family": "Sujan", "given": "Mark", "initials": "M"}, {"family": "Carson-Stevens", "given": "Andrew", "initials": "A"}, {"family": "Ross", "given": "Alistair", "initials": "A"}, {"family": "Bowie", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Saf Sci", "issn": "0925-7535", "volume": "146", "pages": "105525", "issn-l": null}, "abstract": "The most common reaction to suggesting that we could learn valuable lessons from the way the current pandemic has been/ is being handled, is to discourage the attempt; as it is suggested that it can all be done more accurately and authoritatively after the inevitable Public Inquiry (Slater, 2019). On the other hand, a more constructive approach, is to capture and understand the work that was actually done.This would include normal activities, as well as positive adaptations to challenges and failures that may have occurred. Such an approach aimed at improving what worked, rather than blaming people for what went wrong, has the potential to contribute more successfully to controlling the consequences of the current crisis. Such an approach should thus be aimed at detecting and feeding back lessons from emerging and probably unexpected behaviours and helping to design the system to adapt better to counter the effects. The science and discipline of Human Factors (HF) promotes system resilience. This can be defined as an organisation's ability to adjust its functioning before, during or after significant disturbances (such as a pandemic), enabling adaptation and operation under both anticipated and unanticipated circumstances. A \"functional\" approach methodology enables the identification of where the system and its various interdependent functions (an activity or set of activities that are required to give a certain output), could be improved and strengthened; if not immediately, at least for the future. Along these lines, suggestions for adding key resilience functions are additionally identified and outlined. The application and insights gained from this functional approach to the 2015 MERS-Cov pandemic in South Korea has been seen as contributing substantially to the effective response to the current crisis in that country (Min, submitted for publication). In this paper, we present an overarching framework for a series of projects that are planned to carry out focussed systems-based analysis to generate learning from key aspects of the COVID-19 pandemic response in the United Kingdom.", "doi": "10.1016/j.ssci.2021.105525", "pmid": "34658531", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0925-7535(21)00368-4"}, {"db": "pmc", "key": "PMC8501230"}], "notes": [], "created": "2021-10-21T05:01:44.575Z", "modified": "2021-10-21T05:01:44.589Z"}, {"entity": "publication", "iuid": "b145abeb119c458e98cbe2e264a72941", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b145abeb119c458e98cbe2e264a72941.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b145abeb119c458e98cbe2e264a72941"}}, "title": "Pain Burden in Post-COVID-19 Syndrome following Mild COVID-19 Infection.", "authors": [{"family": "Bileviciute-Ljungar", "given": "Indre", "initials": "I"}, {"family": "Norrefalk", "given": "Jan-Rickard", "initials": "JR", "orcid": "0000-0002-7070-3268", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24718b50907344ec9053bfc5d8495f19.json"}}, {"family": "Borg", "given": "Kristian", "initials": "K"}], "type": "journal article", "published": "2022-01-31", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "11", "issue": "3", "pages": "771"}, "abstract": "The global pandemic of SARS-CoV-2 has affected several hundred million people, and many infected people have suffered from a milder initial infection but have never fully recovered. This observational study investigates the pain burden in sufferers of post-COVID-19 syndrome after a milder initial infection. One hundred post-COVID-19 patients filled out questionnaires regarding sociodemographic data, previous comorbidities, present pharmacological treatment, pain intensity and pain localisation. Health-related quality of life, fatigue, emotional status, and insomnia were measured by validated questionnaires. Multiple post-COVID-19 symptoms, including post-exertional malaise, were evaluated by a symptom questionnaire. Among the 100 participants (mean age 44.5 years), 82% were women, 61% had higher education, and 56% were working full or part time. Nine participants reported previous pain or inflammatory conditions. Among the most painful sites were the head/face, chest, lower extremities, and migrating sites. Generalised pain was self-reported by 75 participants and was estimated in 50 participants. Diagnosis of fibromyalgia according to the 2016 criteria was suspected in 40 participants. Subgroup analyses indicated that comorbidities might play a role in the development of pain. In conclusion, a major part of sufferers from post-COVID-19 syndrome develop pain, and in addition to its many disabling symptoms, there is an urgent need for pain management in post-COVID-19 syndrome.", "doi": "10.3390/jcm11030771", "pmid": "35160223", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC8836662"}, {"db": "pii", "key": "jcm11030771"}], "notes": [], "created": "2022-02-17T06:10:30.240Z", "modified": "2023-06-19T15:16:34.767Z"}, {"entity": "publication", "iuid": "453141f6204344c5a19dc358dd5264bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/453141f6204344c5a19dc358dd5264bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/453141f6204344c5a19dc358dd5264bf"}}, "title": "Multi-professional Neurorehabilitation after Covid-19 Infection Should Include Assessment of Visual Function: Visual function after Covid-19 infection.", "authors": [{"family": "Johansson", "given": "Jan", "initials": "J"}, {"family": "Levi", "given": "Richard", "initials": "R"}, {"family": "Jakobsson", "given": "Maria", "initials": "M"}, {"family": "Gunnarsson", "given": "Stina", "initials": "S"}, {"family": "Samuelsson", "given": "Kersti", "initials": "K"}], "type": "journal article", "published": "2022-01-31", "journal": {"title": "Arch Rehabil Res Clin Transl", "issn": "2590-1095", "pages": "100184", "issn-l": null}, "abstract": "To report vision-related symptoms and neuro-visual clinical signs in patients approximately 4 months after discharge from hospitalization after Covid-19 infection. To report on co-existing functional and activity limitations.\n\nThe study is part of an ambi-directional population-based cohort study.\n\nAn outpatient setting in a hospital environment.\n\nPatients from a population-based cohort study including all laboratory-confirmed cases of Covid-19 admitted to hospital during a 3-month period in a health care region in Sweden. Among patients who, based on a standardized telephone interview, were identified as having persisting rehabilitation needs 4 months after discharge (n=185), several (n=57) reported vision-related symptoms. All 57 patients were invited to a neuro-visual examination. Six patients declined, six were unavailable and three did not fulfil the inclusion criteria. Thus 42 patients were included in the analysis.\n\nNot applicable.\n\nVision-related symptoms, neuro-visual function, and co-existing impairments affecting activities of daily life and participation.\n\nThirty-one percent of patients with rehabilitation needs after Covid-19 reported vision-related symptoms. Reading-related issues (73.8%), blurry vision (69.0%), and light sensitivity (66.7%) were the most common symptoms. Patients with reading-related issues showed a higher level of eye strain (p<0.001). Neuro-visual deficits were found in 83.3% of the patients, mainly concerning eye teaming (23.1%-66.7%) and eye movement (28.6%-30.8%) functions. Patients with vision-related symptoms reported fatigue and 18 other co-existing symptoms to a greater extent (p\u22640.0001 to 0.049).\n\nNeuro-visual symptoms and signs should be considered when assessing rehabilitation needs after Covid-19. The association between vision-related issues and co-existing symptoms with an impact on body function and activity/participation underlines the need for multi-professional rehabilitation assessment and intervention.", "doi": "10.1016/j.arrct.2022.100184", "pmid": "35128374", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2590-1095(22)00007-6"}, {"db": "pmc", "key": "PMC8802546"}], "notes": [], "created": "2022-02-08T15:15:20.652Z", "modified": "2022-02-08T15:15:20.658Z"}, {"entity": "publication", "iuid": "b4ec75c22fa64badaf91848a344c0ae3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b4ec75c22fa64badaf91848a344c0ae3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b4ec75c22fa64badaf91848a344c0ae3"}}, "title": "Integrated Sustainable childhood Pneumonia and Infectious disease Reduction in Nigeria (INSPIRING) through whole system strengthening in Jigawa, Nigeria: study protocol for a cluster randomised controlled trial.", "authors": [{"family": "King", "given": "Carina", "initials": "C", "orcid": "0000-0002-6885-6716", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8ac349483b74803a39b937bf149c480.json"}}, {"family": "Burgess", "given": "Rochelle Ann", "initials": "RA"}, {"family": "Bakare", "given": "Ayobami A", "initials": "AA"}, {"family": "Shittu", "given": "Funmilayo", "initials": "F"}, {"family": "Salako", "given": "Julius", "initials": "J"}, {"family": "Bakare", "given": "Damola", "initials": "D"}, {"family": "Uchendu", "given": "Obioma C", "initials": "OC"}, {"family": "Iuliano", "given": "Agnese", "initials": "A"}, {"family": "Isah", "given": "Adamu", "initials": "A"}, {"family": "Adams", "given": "Osebi", "initials": "O"}, {"family": "Haruna", "given": "Ibrahim", "initials": "I"}, {"family": "Magama", "given": "Abdullahi", "initials": "A"}, {"family": "Ahmed", "given": "Tahlil", "initials": "T"}, {"family": "Ahmar", "given": "Samy", "initials": "S"}, {"family": "Cassar", "given": "Christine", "initials": "C"}, {"family": "Valentine", "given": "Paula", "initials": "P"}, {"family": "Olowookere", "given": "Temitayo Folorunso", "initials": "TF"}, {"family": "MacCalla", "given": "Matthew", "initials": "M"}, {"family": "Graham", "given": "Hamish R", "initials": "HR"}, {"family": "McCollum", "given": "Eric D", "initials": "ED"}, {"family": "Falade", "given": "Adegoke G", "initials": "AG"}, {"family": "Colbourn", "given": "Tim", "initials": "T"}, {"family": "INSPIRING Project Consortium", "given": "", "initials": ""}], "type": "clinical trial protocol", "published": "2022-01-31", "journal": {"title": "Trials", "issn": "1745-6215", "volume": "23", "issue": "1", "pages": "95", "issn-l": null}, "abstract": "Child mortality remains unacceptably high, with Northern Nigeria reporting some of the highest rates globally (e.g. 192/1000 live births in Jigawa State). Coverage of key protect and prevent interventions, such as vaccination and clean cooking fuel use, is low. Additionally, knowledge, care-seeking and health system factors are poor. Therefore, a whole systems approach is needed for sustainable reductions in child mortality.\n\nThis is a cluster randomised controlled trial, with integrated process and economic evaluations, conducted from January 2021 to September 2022. The trial will be conducted in Kiyawa Local Government Area, Jigawa State, Nigeria, with an estimated population of 230,000. Clusters are defined as primary government health facility catchment areas (n = 33). The 33 clusters will be randomly allocated (1:1) in a public ceremony, and 32 clusters included in the impact evaluation. The trial will evaluate a locally adapted 'whole systems strengthening' package of three evidence-based methods: community men's and women's groups, Partnership Defined Quality Scorecard and healthcare worker training, mentorship and provision of basic essential equipment and commodities. The primary outcome is mortality of children aged 7 days to 59 months. Mortality will be recorded prospectively using a cohort design, and secondary outcomes measured through baseline and endline cross-sectional surveys. Assuming the following, we will have a minimum detectable effect size of 30%: (a) baseline mortality of 100 per 1000 livebirths, (b) 4480 compounds with 3 eligible children per compound, (c) 80% power, (d) 5% significance, (e) intra-cluster correlation of 0.007 and (f) coefficient of variance of cluster size of 0.74. Analysis will be by intention-to-treat, comparing intervention and control clusters, adjusting for compound and trial clustering.\n\nThis study will provide robust evidence of the effectiveness and cost-effectiveness of community-based participatory learning and action, with integrated health system strengthening and accountability mechanisms, to reduce child mortality. The ethnographic process evaluation will allow for a rich understanding of how the intervention works in this context. However, we encountered a key challenge in calculating the sample size, given the lack of timely and reliable mortality data and the uncertain impacts of the COVID-19 pandemic.\n\nISRCTN 39213655 . Registered on 11 December 2019.", "doi": "10.1186/s13063-021-05859-5", "pmid": "35101109", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13063-021-05859-5"}, {"db": "pmc", "key": "PMC8802253"}], "notes": [], "created": "2022-02-06T16:52:28.794Z", "modified": "2022-02-06T16:52:28.819Z"}, {"entity": "publication", "iuid": "4605d61423c84be6a37ba9454a1991a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4605d61423c84be6a37ba9454a1991a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4605d61423c84be6a37ba9454a1991a9"}}, "title": "Global case fatality rate of coronavirus disease 2019 (COVID-19) by continents and national income: a meta-analysis.", "authors": [{"family": "Ghayda", "given": "Ramy Abou", "initials": "RA"}, {"family": "Lee", "given": "Keum Hwa", "initials": "KH"}, {"family": "Han", "given": "Young Joo", "initials": "YJ"}, {"family": "Ryu", "given": "Seohyun", "initials": "S"}, {"family": "Hong", "given": "Sung Hwi", "initials": "SH"}, {"family": "Yoon", "given": "Sojung", "initials": "S"}, {"family": "Jeong", "given": "Gwang Hun", "initials": "GH"}, {"family": "Yang", "given": "Jae Won", "initials": "JW"}, {"family": "Lee", "given": "Hyo Jeong", "initials": "HJ"}, {"family": "Lee", "given": "Jinhee", "initials": "J"}, {"family": "Lee", "given": "Jun Young", "initials": "JY"}, {"family": "Effenberger", "given": "Maria", "initials": "M"}, {"family": "Eisenhut", "given": "Michael", "initials": "M"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Solmi", "given": "Marco", "initials": "M"}, {"family": "Li", "given": "Han", "initials": "H"}, {"family": "Jacob", "given": "Louis", "initials": "L"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Park", "given": "Myung Bae", "initials": "MB"}, {"family": "Aghayeva", "given": "Sevda", "initials": "S"}, {"family": "Ahmed", "given": "Mohamed Lemine Cheikh Brahim", "initials": "MLCB"}, {"family": "Serouri", "given": "Abdulwahed Al", "initials": "AA"}, {"family": "Al-Shamsi", "given": "Humaid O", "initials": "HO"}, {"family": "Amir-Behghadami", "given": "Mehrdad", "initials": "M"}, {"family": "Baatarkhuu", "given": "Oidov", "initials": "O"}, {"family": "Bashour", "given": "Hyam", "initials": "H"}, {"family": "Bondarenko", "given": "Anastasiia", "initials": "A"}, {"family": "Camacho-Ortiz", "given": "Adrian", "initials": "A"}, {"family": "Castro", "given": "Franz", "initials": "F"}, {"family": "Cox", "given": "Horace", "initials": "H"}, {"family": "Davtyan", "given": "Hayk", "initials": "H"}, {"family": "Douglas", "given": "Kirk", "initials": "K"}, {"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Ebrahim", "given": "Shahul", "initials": "S"}, {"family": "Ferioli", "given": "Martina", "initials": "M"}, {"family": "Harapan", "given": "Harapan", "initials": "H"}, {"family": "Mallah", "given": "Saad I", "initials": "SI"}, {"family": "Ikram", "given": "Aamer", "initials": "A"}, {"family": "Inoue", "given": "Shigeru", "initials": "S"}, {"family": "Jankovic", "given": "Slobodan", "initials": "S"}, {"family": "Jayarajah", "given": "Umesh", "initials": "U", "orcid": "0000-0002-0398-5197", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0bea00924415424fa7972f7aef4788f1.json"}}, {"family": "Jesenak", "given": "Milos", "initials": "M"}, {"family": "Kakodkar", "given": "Pramath", "initials": "P"}, {"family": "Kebede", "given": "Yohannes", "initials": "Y"}, {"family": "Kifle", "given": "Meron", "initials": "M"}, {"family": "Koh", "given": "David", "initials": "D"}, {"family": "Males", "given": "Visnja Kokic", "initials": "VK"}, {"family": "Kotfis", "given": "Katarzyna", "initials": "K"}, {"family": "Lakoh", "given": "Sulaiman", "initials": "S"}, {"family": "Ling", "given": "Lowell", "initials": "L"}, {"family": "Llibre-Guerra", "given": "Jorge", "initials": "J"}, {"family": "Machida", "given": "Masaki", "initials": "M"}, {"family": "Makurumidze", "given": "Richard", "initials": "R"}, {"family": "Mamun", "given": "Mohammed", "initials": "M", "orcid": "0000-0002-1728-8966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6e65a5a97154d159a63cc2ce3f1b7a8.json"}}, {"family": "Masic", "given": "Izet", "initials": "I"}, {"family": "Van Minh", "given": "Hoang", "initials": "H"}, {"family": "Moiseev", "given": "Sergey", "initials": "S"}, {"family": "Nadasdy", "given": "Thomas", "initials": "T"}, {"family": "Nahshon", "given": "Chen", "initials": "C"}, {"family": "\u00d1amendys-Silva", "given": "Silvio A", "initials": "SA"}, {"family": "Yongsi", "given": "Blaise Nguendo", "initials": "BN"}, {"family": "Nielsen", "given": "Henning Bay", "initials": "HB"}, {"family": "Nodjikouambaye", "given": "Zita Aleyo", "initials": "ZA"}, {"family": "Ohnmar", "given": "Ohnmar", "initials": "O"}, {"family": "Oksanen", "given": "Atte", "initials": "A", "orcid": "0000-0003-4143-5580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ad67f37abe44c1aa0e75421648cfb0d.json"}}, {"family": "Owopetu", "given": "Oluwatomi", "initials": "O"}, {"family": "Parperis", "given": "Konstantinos", "initials": "K"}, {"family": "Perez", "given": "Gonzalo Emanuel", "initials": "GE"}, {"family": "Pongpirul", "given": "Krit", "initials": "K"}, {"family": "Rademaker", "given": "Marius", "initials": "M"}, {"family": "Rosa", "given": "Sandro", "initials": "S"}, {"family": "Sah", "given": "Ranjit", "initials": "R"}, {"family": "Sallam", "given": "Dina", "initials": "D"}, {"family": "Schober", "given": "Patrick", "initials": "P"}, {"family": "Singhal", "given": "Tanu", "initials": "T"}, {"family": "Tafaj", "given": "Silva", "initials": "S"}, {"family": "Torres", "given": "Irene", "initials": "I"}, {"family": "Smith Torres-Roman", "given": "J", "initials": "J"}, {"family": "Tsartsalis", "given": "Dimitrios", "initials": "D"}, {"family": "Tsolmon", "given": "Jadamba", "initials": "J"}, {"family": "Tuychiev", "given": "Laziz", "initials": "L"}, {"family": "Vukcevic", "given": "Batric", "initials": "B"}, {"family": "Wanghi", "given": "Guy", "initials": "G"}, {"family": "Wollina", "given": "Uwe", "initials": "U"}, {"family": "Xu", "given": "Ren-He", "initials": "R"}, {"family": "Yang", "given": "Lin", "initials": "L"}, {"family": "Zaidi", "given": "Zoubida", "initials": "Z"}, {"family": "Smith", "given": "Lee", "initials": "L"}, {"family": "Shin", "given": "Jae Il", "initials": "JI", "orcid": "0000-0003-2326-1820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ca450cb43e3478d81ba93be745f0ea0.json"}}], "type": "journal article", "published": "2022-01-31", "journal": {"title": "J Med Virol", "issn": "1096-9071", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The aim of this study is to provide a more accurate representation of COVID-19's CFR by performing meta-analyses by continents and income, and by comparing the result with pooled estimates. We used multiple worldwide data sources on COVID-19 for every country reporting COVID-19 cases. Based on the data, we performed random and fixed meta-analyses for CFR of COVID-19 by continents and income according to each individual calendar date. CFR were estimated based on the different geographical regions and level of income using three models: pooled estimates, fixed- and random-model. In Asia, all three types of CFR initially remained approximately between 2.0% and 3.0%. In the case of pooled estimates and the fixed model results, CFR increased to 4.0%, by then gradually decreasing, while in the case of random-model, CFR remained under 2.0%. Similarly, in Europe, initially the two types of CFR peaked at 9.0% and 10.0%, respectively. The random-model results showed an increase near 5.0%. In high income countries, pooled estimates and fixed-model showed gradually increasing trends with a final pooled estimates and random-model reached about 8.0% and 4.0%, respectively. In middle-income, the pooled estimates and fixed-model have gradually increased reaching up to 4.5%. in low-income countries, CFRs remained similar between 1.5% and 3.0%. Our study emphasizes that COVID-19 CFR is not a fixed or static value. Rather, it is a dynamic estimate that changes with time, population, socioeconomic factors and the mitigatory efforts of individuals countries. This article is protected by copyright. All rights reserved.", "doi": "10.1002/jmv.27610", "pmid": "35099819", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-02-06T16:54:07.571Z", "modified": "2022-02-06T16:54:40.249Z"}, {"entity": "publication", "iuid": "05cec7cdf3064c9c9162018fddda120d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/05cec7cdf3064c9c9162018fddda120d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/05cec7cdf3064c9c9162018fddda120d"}}, "title": "Evaluation serum levels of Insulin Growth Factor-1 (IGF-1) and its association with clinical parameters in severe COVID-19.", "authors": [{"family": "Feizollahi", "given": "Parisa", "initials": "P"}, {"family": "Matin", "given": "Somaieh", "initials": "S"}, {"family": "Roghani", "given": "Seyed Askar", "initials": "SA"}, {"family": "Mostafaei", "given": "Shayan", "initials": "S"}, {"family": "Safarzadeh", "given": "Elham", "initials": "E"}, {"family": "Taghadosi", "given": "Mahdi", "initials": "M", "orcid": "0000-0002-3516-0130", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f30112bc6d6140479d16934f5223e9a4.json"}}], "type": "journal article", "published": "2022-01-31", "journal": {"title": "Inflammopharmacology", "issn": "1568-5608", "issn-l": null}, "abstract": "Severe coronavirus disease-2019 (COVID-19) is associated with dysregulated immune response and extreme inflammatory injury. Considering the role of insulin growth factor-1 (IGF-1) in immune-mediated and inflammatory reactions, this study was conducted to investigate the IGF-1 contribution to the pathogenesis of severe form of COVID-19.\n\nSixty-two patients with severe COVID-19 and 52 healthy subjects were enrolled in this study. The serum levels of IGF-1 were measured using a solid-phase enzyme-linked chemiluminescent immunoassay on an Immulite 2000 system (Siemens Healthcare Diagnostics.\n\nThe serum levels of IGF-1 had no significant difference in COVID-19 patients compared to the healthy subjects (p = 0.359). There was a positive correlation between IGF-1 and age in the severe COVID-19 patients, while a negative correlation was observed for the serum levels of IGF-1 and age in the control group (r = 0.364, p = 0.036, r = - 0.536, p = 0.001, respectively). Moreover, IGF-1 was remarkably associated with hypertension, neurogenic disease, shock, and nausea in patients with the severe form of COVID-19 (p = 0.031, p = 0.044, p = 0.01, p = 0.03, respectively).\n\nOur results pointed to the complex role of IGF-1 in the severe form of COVID-19, and its association with clinical parameters, and some risk factors in the severe form of COVID-19.", "doi": "10.1007/s10787-021-00908-6", "pmid": "35098386", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10787-021-00908-6"}, {"db": "pmc", "key": "PMC8801278"}], "notes": [], "created": "2022-02-06T16:55:44.236Z", "modified": "2022-02-06T16:55:44.304Z"}, {"entity": "publication", "iuid": "b56709f19e1e42c5b849ae05e968851d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b56709f19e1e42c5b849ae05e968851d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b56709f19e1e42c5b849ae05e968851d"}}, "title": "Bacterial co-infections in community-acquired pneumonia caused by SARS-CoV-2, influenza virus and respiratory syncytial virus.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P"}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Ternhag", "given": "Anders", "initials": "A"}, {"family": "Abdel-Halim", "given": "Lina", "initials": "L"}, {"family": "Hedlund", "given": "Jonas", "initials": "J"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2022-01-31", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "volume": "22", "issue": "1", "pages": "108", "issn-l": null}, "abstract": "A mismatch between a widespread use of broad-spectrum antibiotic agents and a low prevalence of reported bacterial co-infections in patients with SARS-CoV-2 infections has been observed. Herein, we sought to characterize and compare bacterial co-infections at admission in hospitalized patients with SARS-CoV-2, influenza or respiratory syncytial virus (RSV) positive community-acquired pneumonia (CAP).\n\nA retrospective cohort study of bacterial co-infections at admission in SARS-CoV-2, influenza or RSV-positive adult patients with CAP admitted to Karolinska University Hospital in Stockholm, Sweden, from year 2011 to 2020. The prevalence of bacterial co-infections was investigated and compared between the three virus groups. In each virus group, length of stay, ICU-admission and 30-day mortality was compared in patients with and without bacterial co-infection, adjusting for age, sex and co-morbidities. In the SARS-CoV-2 group, risk factors for bacterial co-infection, were assessed using logistic regression models and creation of two scoring systems based on disease severity, age, co-morbidities and inflammatory markers with assessment of concordance statistics.\n\nCompared to influenza and RSV, the bacterial co-infection testing frequency in SARS-CoV-2 was lower for all included test modalities. Four percent [46/1243 (95% CI 3-5)] of all SARS-CoV-2 patients had a bacterial co-infection at admission, whereas the proportion was 27% [209/775 (95% CI 24-30)] and 29% [69/242 (95% CI 23-35)] in influenza and RSV, respectively. S. pneumoniae and S. aureus constituted the most common bacterial findings for all three virus groups. Comparing SARS-CoV-2 positive patients with and without bacterial co-infection at admission, a relevant association could not be demonstrated nor excluded with regards to risk of ICU-admission (aHR 1.53, 95% CI 0.87-2.69) or 30-day mortality (aHR 1.28, 95% CI 0.66-2.46) in adjusted analyses. Bacterial co-infection was associated with increased inflammatory markers, but the diagnostic accuracy was not substantially different in a scoring system based on disease severity, age, co-morbidities and inflammatory parameters [C statistic 0.66 (95% CI 0.59-0.74)], compared to using disease severity, age and co-morbidities only [C statistic 0.63 (95% CI 0.56-0.70)].\n\nThe prevalence of bacterial co-infections was significantly lower in patients with community-acquired SARS-CoV-2 positive pneumonia as compared to influenza and RSV positive pneumonia.", "doi": "10.1186/s12879-022-07089-9", "pmid": "35100984", "labels": {"Category: Health": null, "Type: Journal article": null, "Funder: Vinnova": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12879-022-07089-9"}, {"db": "pmc", "key": "PMC8802536"}], "notes": [], "created": "2022-02-06T16:52:51.200Z", "modified": "2022-02-06T16:53:31.048Z"}, {"entity": "publication", "iuid": "a5fae45113934b8bb907e66a3b263b48", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a5fae45113934b8bb907e66a3b263b48.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a5fae45113934b8bb907e66a3b263b48"}}, "title": "Assessing How Consumers Interpret and Act on Results From At-Home COVID-19 Self-test Kits: A Randomized Clinical Trial.", "authors": [{"family": "Woloshin", "given": "Steven", "initials": "S"}, {"family": "Dewitt", "given": "Barry", "initials": "B"}, {"family": "Krishnamurti", "given": "Tamar", "initials": "T"}, {"family": "Fischhoff", "given": "Baruch", "initials": "B"}], "type": "journal article", "published": "2022-01-31", "journal": {"title": "JAMA Intern Med", "issn": "2168-6114", "issn-l": null}, "abstract": "The US Food and Drug Administration (FDA) authorized SARS-CoV-2 rapid at-home self-test kits for individuals with and without symptoms. How appropriately users interpret and act on the results of at-home COVID-19 self-tests is unknown.\n\nTo assess how users of at-home COVID-19 self-test kits interpret and act on results when given instructions authorized by the FDA, instructions based on decision science principles, or no instructions.\n\nA randomized clinical trial was conducted of 360 adults in the US who were recruited in April 2021 to complete an online survey on their interpretation of at-home COVID-19 self-test results. Participants were given 1 of 3 instruction types and were presented with 1 of 4 risk scenarios. Participants were paid $5 and had a median survey completion time of 8.7 minutes. Data analyses were performed from June to July 2021.\n\nParticipants were randomized to receiving either the FDA-authorized instructions (authorized), the intervention instructions (intervention), or no instructions (control), and to 1 of 4 scenarios: 3 with a high pretest probability of infection (COVID-19 symptoms and/or a close contact with COVID-19) and 1 with low pretest probability (no symptoms and no contact). The intervention instructions were designed using decision science principles.\n\nProportion of participants in the high pretest probability scenarios choosing to quarantine per federal recommendations and perceived probabilities of infection given a negative or positive COVID-19 test result. A Bonferroni correction accounted for multiple comparisons (3 instruction types \u00d7 4 scenarios; \u03b1 = 0.004).\n\nAfter excluding 22 individuals who completed the survey too quickly, the responses of 338 participants (median [IQR] age, 38 [31 to 48] years; 154 (46%) women; 215 (64%) with a college degree or higher) were included in the study analysis. Given a positive test result, 95% (322 of 338; 95% CI, 0.92 to 0.97) of the total participants appropriately chose to quarantine regardless of which instructions they had received. Given a negative test result, participants in the high pretest probability scenarios were more likely to fail to quarantine appropriately with the authorized instructions (33%) than with the intervention (14%; 95% CI for the 19% difference, 6% to 31%; P = .004) or control (24%; 95% CI for the 9% difference, -4% to 23%; P = .02). In the low pretest probability scenario, the proportion choosing unnecessary quarantine was higher with the authorized instructions (31%) than with the intervention (22%; 95% CI for the 9% difference, -14% to 31%) or control (10%; 95% CI for the 21% difference, 0.5% to 41%)-neither comparison was statistically significant (P = .05 and P = .20 respectively).\n\nThe findings of this randomized clinical trial indicate that at-home COVID-19 self-test kit users relying on the authorized instructions may not follow the Centers for Disease Control and Prevention's quarantine recommendations, producing unintended risks and unnecessary disruptions. Redesigned instructions that follow decision science principles may improve compliance.\n\nClinicalTrials.gov Identifier: NCT04758299.", "doi": "10.1001/jamainternmed.2021.8075", "pmid": "35099501", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "2788656"}, {"db": "ClinicalTrials.gov", "key": "NCT04758299"}], "notes": [], "created": "2022-02-06T16:54:52.435Z", "modified": "2022-02-06T16:55:06.381Z"}, {"entity": "publication", "iuid": "93039f55bd154261b34650b56b1ce76f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/93039f55bd154261b34650b56b1ce76f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/93039f55bd154261b34650b56b1ce76f"}}, "title": "An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection.", "authors": [{"family": "Sanchez-Burgos", "given": "Laura", "initials": "L"}, {"family": "G\u00f3mez-L\u00f3pez", "given": "Gonzalo", "initials": "G"}, {"family": "Al-Shahrour", "given": "F\u00e1tima", "initials": "F"}, {"family": "Fernandez-Capetillo", "given": "Oscar", "initials": "O"}], "type": "journal article", "published": "2022-01-31", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "12", "issue": "1", "pages": "1626"}, "abstract": "The ongoing COVID-19 pandemic is one of the biggest health challenges of recent decades. Among the causes of mortality triggered by SARS-CoV-2 infection, the development of an inflammatory \"cytokine storm\" (CS) plays a determinant role. Here, we used transcriptomic data from the bronchoalveolar lavage fluid (BALF) of COVID-19 patients undergoing a CS to obtain gene-signatures associated to this pathology. Using these signatures, we interrogated the Connectivity Map (CMap) dataset that contains the effects of over 5000 small molecules on the transcriptome of human cell lines, and looked for molecules which effects on transcription mimic or oppose those of the CS. As expected, molecules that potentiate immune responses such as PKC activators are predicted to worsen the CS. In addition, we identified the negative regulation of female hormones among pathways potentially aggravating the CS, which helps to understand the gender-related differences in COVID-19 mortality. Regarding drugs potentially counteracting the CS, we identified glucocorticoids as a top hit, which validates our approach as this is the primary treatment for this pathology. Interestingly, our analysis also reveals a potential effect of MEK inhibitors in reverting the COVID-19 CS, which is supported by in vitro data that confirms the anti-inflammatory properties of these compounds.", "doi": "10.1038/s41598-022-05597-x", "pmid": "35102208", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-05597-x"}], "notes": [], "created": "2022-02-04T16:00:23.387Z", "modified": "2022-02-04T16:02:21.636Z"}, {"entity": "publication", "iuid": "fe7406372e8d41658b99738bd1fd23cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fe7406372e8d41658b99738bd1fd23cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fe7406372e8d41658b99738bd1fd23cc"}}, "title": "Seek COVER: using a disease proxy to rapidly develop and validate a personalized risk calculator for COVID-19 outcomes in an international network.", "authors": [{"family": "Williams", "given": "Ross D", "initials": "RD"}, {"family": "Markus", "given": "Aniek F", "initials": "AF"}, {"family": "Yang", "given": "Cynthia", "initials": "C"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "DuVall", "given": "Scott L", "initials": "SL"}, {"family": "Falconer", "given": "Thomas", "initials": "T"}, {"family": "Jonnagaddala", "given": "Jitendra", "initials": "J"}, {"family": "Kim", "given": "Chungsoo", "initials": "C"}, {"family": "Rho", "given": "Yeunsook", "initials": "Y"}, {"family": "Williams", "given": "Andrew E", "initials": "AE"}, {"family": "Machado", "given": "Amanda Alberga", "initials": "AA"}, {"family": "An", "given": "Min Ho", "initials": "MH"}, {"family": "Arag\u00f3n", "given": "Mar\u00eda", "initials": "M"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Burn", "given": "Edward", "initials": "E"}, {"family": "Choi", "given": "Young Hwa", "initials": "YH"}, {"family": "Drakos", "given": "Iannis", "initials": "I"}, {"family": "Abrah\u00e3o", "given": "Maria Tereza Fernandes", "initials": "MTF"}, {"family": "Fern\u00e1ndez-Bertol\u00edn", "given": "Sergio", "initials": "S"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Kaas-Hansen", "given": "Benjamin Skov", "initials": "BS"}, {"family": "Kandukuri", "given": "Prasanna L", "initials": "PL"}, {"family": "Kors", "given": "Jan A", "initials": "JA"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Liaw", "given": "Siaw-Teng", "initials": "ST"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Machnicki", "given": "Gerardo", "initials": "G"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Morales", "given": "Daniel", "initials": "D"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Park", "given": "Rae Woong", "initials": "RW"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A"}, {"family": "Pratt", "given": "Nicole", "initials": "N"}, {"family": "Rao", "given": "Gowtham", "initials": "G"}, {"family": "Reich", "given": "Christian G", "initials": "CG"}, {"family": "Rivera", "given": "Marcela", "initials": "M"}, {"family": "Seinen", "given": "Tom", "initials": "T"}, {"family": "Shoaibi", "given": "Azza", "initials": "A"}, {"family": "Spotnitz", "given": "Matthew E", "initials": "ME"}, {"family": "Steyerberg", "given": "Ewout W", "initials": "EW"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhou", "given": "Lili", "initials": "L"}, {"family": "Ryan", "given": "Patrick B", "initials": "PB"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Reps", "given": "Jenna M", "initials": "JM"}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR"}], "type": "journal article", "published": "2022-01-30", "journal": {"title": "BMC Med Res Methodol", "issn": "1471-2288", "volume": "22", "issue": "1", "pages": "35", "issn-l": null}, "abstract": "We investigated whether we could use influenza data to develop prediction models for COVID-19 to increase the speed at which prediction models can reliably be developed and validated early in a pandemic. We developed COVID-19 Estimated Risk (COVER) scores that quantify a patient's risk of hospital admission with pneumonia (COVER-H), hospitalization with pneumonia requiring intensive services or death (COVER-I), or fatality (COVER-F) in the 30-days following COVID-19 diagnosis using historical data from patients with influenza or flu-like symptoms and tested this in COVID-19 patients.\n\nWe analyzed a federated network of electronic medical records and administrative claims data from 14 data sources and 6 countries containing data collected on or before 4/27/2020. We used a 2-step process to develop 3 scores using historical data from patients with influenza or flu-like symptoms any time prior to 2020. The first step was to create a data-driven model using LASSO regularized logistic regression, the covariates of which were used to develop aggregate covariates for the second step where the COVER scores were developed using a smaller set of features. These 3 COVER scores were then externally validated on patients with 1) influenza or flu-like symptoms and 2) confirmed or suspected COVID-19 diagnosis across 5 databases from South Korea, Spain, and the United States. Outcomes included i) hospitalization with pneumonia, ii) hospitalization with pneumonia requiring intensive services or death, and iii) death in the 30 days after index date.\n\nOverall, 44,507 COVID-19 patients were included for model validation. We identified 7 predictors (history of cancer, chronic obstructive pulmonary disease, diabetes, heart disease, hypertension, hyperlipidemia, kidney disease) which combined with age and sex discriminated which patients would experience any of our three outcomes. The models achieved good performance in influenza and COVID-19 cohorts. For COVID-19 the AUC ranges were, COVER-H: 0.69-0.81, COVER-I: 0.73-0.91, and COVER-F: 0.72-0.90. Calibration varied across the validations with some of the COVID-19 validations being less well calibrated than the influenza validations.\n\nThis research demonstrated the utility of using a proxy disease to develop a prediction model. The 3 COVER models with 9-predictors that were developed using influenza data perform well for COVID-19 patients for predicting hospitalization, intensive services, and fatality. The scores showed good discriminatory performance which transferred well to the COVID-19 population. There was some miscalibration in the COVID-19 validations, which is potentially due to the difference in symptom severity between the two diseases. A possible solution for this is to recalibrate the models in each location before use.", "doi": "10.1186/s12874-022-01505-z", "pmid": "35094685", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8801189"}, {"db": "pii", "key": "10.1186/s12874-022-01505-z"}], "notes": [], "created": "2022-02-06T17:04:47.177Z", "modified": "2023-06-19T15:02:04.233Z"}, {"entity": "publication", "iuid": "5ff0cd52aeff4d118b9046cb52f729a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5ff0cd52aeff4d118b9046cb52f729a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5ff0cd52aeff4d118b9046cb52f729a9"}}, "title": "The experiences of early career geriatricians throughout Europe during the COVID-19 pandemic.", "authors": [{"family": "Mezera", "given": "Vojtech", "initials": "V", "orcid": "0000-0002-8679-5208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53a0de0cbddb4ee8b35b5c6302159732.json"}}, {"family": "Ekdahl", "given": "Anne W", "initials": "AW"}, {"family": "Bertschi", "given": "Dominic", "initials": "D"}, {"family": "Bonnici", "given": "Maria", "initials": "M"}, {"family": "Buzaco", "given": "Rui", "initials": "R"}, {"family": "Rodeles", "given": "Santiago Cotobal", "initials": "SC"}, {"family": "Eruslanova", "given": "Kseniia", "initials": "K"}, {"family": "Matchekhina", "given": "Lubov", "initials": "L"}, {"family": "Bazan", "given": "Laura Monica Perez", "initials": "LMP"}, {"family": "Epelde", "given": "Itxaso Marin", "initials": "IM"}, {"family": "Kotsani", "given": "Marina", "initials": "M"}, {"family": "Femminella", "given": "Grazia Daniela", "initials": "GD"}, {"family": "Koca", "given": "Meltem", "initials": "M"}, {"family": "Dejaeger", "given": "Marian", "initials": "M"}], "type": "journal article", "published": "2022-01-29", "journal": {"title": "Eur Geriatr Med", "issn": "1878-7649", "issn-l": null}, "abstract": "The COVID-19 pandemic has severely affected older adults and brought about unprecedented challenges to geriatricians. We aimed to evaluate the experiences of early career geriatricians (residents or consultants with up to 10 years of experience) throughout Europe using an online survey. We obtained 721 responses. Most of the respondents were females (77.8%) and residents in geriatric medicine (54.6%). The majority (91.4%) were directly involved in the care of patients with COVID-19. The respondents reported moderate levels of anxiety and feelings of being overloaded with work. The anxiety levels were higher in women than in men. Most of the respondents experienced a feeling of a strong restriction on their private lives and a change in their work routine. The residents also reported a moderate disruption in their training and research activities. In conclusion, early career geriatricians experienced a major impact of COVID-19 on their professional and private lives.", "doi": "10.1007/s41999-021-00605-1", "pmid": "35091891", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s41999-021-00605-1"}], "notes": [], "created": "2022-01-31T11:42:19.651Z", "modified": "2022-01-31T11:42:19.721Z"}, {"entity": "publication", "iuid": "98c961ceb77b450cbb159b7679a93ff0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/98c961ceb77b450cbb159b7679a93ff0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/98c961ceb77b450cbb159b7679a93ff0"}}, "title": "The impact of Covid-19 on the initiation of clinical trials in Europe and the United States.", "authors": [{"family": "Lasch", "given": "Florian", "initials": "F"}, {"family": "Psarelli", "given": "Eftychia-Eirini", "initials": "EE"}, {"family": "Herold", "given": "Ralf", "initials": "R"}, {"family": "Mattsson", "given": "Andrea", "initials": "A"}, {"family": "Guizzaro", "given": "Lorenzo", "initials": "L"}, {"family": "P\u00e9tavy", "given": "Frank", "initials": "F"}, {"family": "Schiel", "given": "Anja", "initials": "A"}], "type": "journal article", "published": "2022-01-28", "journal": {"title": "Clin Pharmacol Ther", "issn": "1532-6535", "issn-l": null}, "abstract": "The Covid-19 pandemic has a major impact not only on public health and daily living, but also on clinical trials worldwide. To investigate the potential impact of the Covid-19 pandemic on the initiation of clinical trials, we have descriptively analysed the longitudinal change in phase II and III interventional clinical trials initiated in Europe and in the United States. Based on the public clinical trial register EU Clinical Trials Register and clinicaltrials.gov, we conducted (a) a yearly comparison of the number of initiated trials from 2010 to 2020 and (b) a monthly comparison from January 2020 to February 2021 of the number of initiated trials. The analyses indicate that the Covid-19 pandemic affected both the initiation of clinical trials overall and the initiation of non-Covid-19 trials. An increase in the overall numbers of clinical trials could be observed both in Europe and the US in 2020 as compared to 2019. However, the number of non-Covid-19 trials initiated is reduced as compared to the previous decade, with a slightly larger relative decrease in the US as compared to Europe. Additionally, the monthly trend for the initiation of non-Covid-19 trials differs between regions. In the US, after a sharp decrease in April 2020, trial numbers reached the levels of 2019 from June 2020 onwards. In Europe, the decrease was less pronounced, but trial numbers mainly remained below the 2019 average until February 2021.", "doi": "10.1002/cpt.2534", "pmid": "35090044", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-31T11:43:04.018Z", "modified": "2022-01-31T11:43:04.042Z"}, {"entity": "publication", "iuid": "f26455ac99bd45c1a392a3fbd85b2979", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f26455ac99bd45c1a392a3fbd85b2979.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f26455ac99bd45c1a392a3fbd85b2979"}}, "title": "Social Skills Group Training for Students with Neurodevelopmental Disabilities in Senior High School-A Qualitative Multi-Perspective Study of Social Validity.", "authors": [{"family": "Leifler", "given": "Emma", "initials": "E", "orcid": "0000-0001-5007-0996", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61adfbe1d8e64ceab6c076053cb6ad94.json"}}, {"family": "Coco", "given": "Christina", "initials": "C", "orcid": "0000-0001-7963-8637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29565879a0ef4cb088318d41df64b633.json"}}, {"family": "Fridell", "given": "Anna", "initials": "A"}, {"family": "Borg", "given": "Anna", "initials": "A"}, {"family": "B\u00f6lte", "given": "Sven", "initials": "S"}], "type": "journal article", "published": "2022-01-28", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "3", "issn-l": null}, "abstract": "Including students with neurodevelopmental disabilities (NDDs) in regular classrooms has become a law-enforced common practice in many high- and middle-income countries. Still, without appropriate actions supporting the implementation of inclusive pedagogical practice, students with NDDs remain at increased risk for absenteeism, bullying and underachievement. There is limited knowledge on the feasibility of social skills group training (SSGT) in naturalistic settings. Using a qualitative approach, the objective of this study was to explore the lived experiences of (i) students diagnosed with autism or attention-deficit hyperactivity disorder and those showing subclinical social difficulties receiving either SSGT or active social control activities in a regular senior high school setting, (ii) teachers providing SSGT or the active control activity and (iii) school leaders facilitating the implementation of these actions. Due to the impact of the COVID-19 pandemic, comparison between real life versus digital administration of SSGT was also examined. Within a randomized controlled pilot trial of the school-tailored SSGT SKOLKONTAKT\u00ae, the primary perspectives of 20 students, teachers and school leaders on SSGT or the social control activities were explored. All groups perceived SSGT to enhance school attendance and academic achievement of students, as well as teacher inclusion skills and the social school climate. Findings indicate that SSGT is largely feasible and socially valid, and broader implementation of SSGT in school settings appears meaningful.", "doi": "10.3390/ijerph19031487", "pmid": "35162512", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph19031487"}], "notes": [], "created": "2022-02-17T06:09:18.094Z", "modified": "2022-02-17T06:09:18.193Z"}, {"entity": "publication", "iuid": "c9bcbac993ca42218a2c39ff2598c89c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9bcbac993ca42218a2c39ff2598c89c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9bcbac993ca42218a2c39ff2598c89c"}}, "title": "Inherited IFNAR1 Deficiency in a Child with Both Critical COVID-19 Pneumonia and Multisystem Inflammatory Syndrome.", "authors": [{"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Landegren", "given": "Nils", "initials": "N"}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Materna", "given": "Marie", "initials": "M"}, {"family": "Modaresi", "given": "Mohammadreza", "initials": "M"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Aranda-Guill\u00e9n", "given": "Maribel", "initials": "M"}, {"family": "Sardh", "given": "Fabian", "initials": "F"}, {"family": "Zuo", "given": "Fanglei", "initials": "F"}, {"family": "Zhang", "given": "Peng", "initials": "P"}, {"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Marr", "given": "Nico", "initials": "N"}, {"family": "Khan", "given": "Taushif", "initials": "T"}, {"family": "Ata", "given": "Manar", "initials": "M"}, {"family": "Al-Ali", "given": "Fatima", "initials": "F"}, {"family": "Pescarmona", "given": "Remi", "initials": "R"}, {"family": "Belot", "given": "Alexandre", "initials": "A"}, {"family": "B\u00e9ziat", "given": "Vivien", "initials": "V"}, {"family": "Zhang", "given": "Qian", "initials": "Q"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL"}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q", "orcid": "0000-0003-1990-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94a32366862b470eba3a15521b9be290.json"}}], "type": "journal article", "published": "2022-01-28", "journal": {"title": "J Clin Immunol", "issn": "1573-2592", "issn-l": "0271-9142"}, "abstract": "Inborn errors of immunity (IEI) and autoantibodies to type I interferons (IFNs) underlie critical COVID-19 pneumonia in at least 15% of the patients, while the causes of multisystem inflammatory syndrome in children (MIS-C) remain elusive.\n\nTo detect causal genetic variants in very rare cases with concomitant critical COVID-19 pneumonia and MIS-C.\n\nWhole exome sequencing was performed, and the impact of candidate gene variants was investigated. Plasma levels of cytokines, specific antibodies against the virus, and autoantibodies against type I IFNs were also measured.\n\nWe report a 3-year-old child who died on day 56 of SARS-CoV-2 infection with an unusual clinical presentation, combining both critical COVID-19 pneumonia and MIS-C. We identified a large, homozygous loss-of-function deletion in IFNAR1, underlying autosomal recessive IFNAR1 deficiency.\n\nOur findings confirm that impaired type I IFN immunity can underlie critical COVID-19 pneumonia, while suggesting that it can also unexpectedly underlie concomitant MIS-C. Our report further raises the possibility that inherited or acquired dysregulation of type I IFN immunity might contribute to MIS-C in other patients.", "doi": "10.1007/s10875-022-01215-7", "pmid": "35091979", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10875-022-01215-7"}], "notes": [], "created": "2022-01-31T11:41:50.645Z", "modified": "2022-01-31T11:41:50.669Z"}, {"entity": "publication", "iuid": "2de0e4d64ed54d4380102d6aba32653b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2de0e4d64ed54d4380102d6aba32653b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2de0e4d64ed54d4380102d6aba32653b"}}, "title": "Corrigendum to \"Error rates in SARS-CoV-2 testing examined with Bayes' theorem\" [Heliyon 7 (4), (April 2021) Article e06905].", "authors": [{"family": "Bentley", "given": "Phillip", "initials": "P"}], "type": "published erratum", "published": "2022-01-28", "journal": {"title": "Heliyon", "issn": "2405-8440", "pages": "e08836", "issn-l": null}, "abstract": "[This corrects the article DOI: 10.1016/j.heliyon.2021.e06905.].", "doi": "10.1016/j.heliyon.2022.e08836", "pmid": "35106385", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(22)00124-4"}, {"db": "pmc", "key": "PMC8795781"}], "notes": [], "created": "2022-02-06T16:50:42.414Z", "modified": "2022-02-06T16:50:42.429Z"}, {"entity": "publication", "iuid": "00f475c5a60449c68afa511f7dbbf937", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/00f475c5a60449c68afa511f7dbbf937.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/00f475c5a60449c68afa511f7dbbf937"}}, "title": "Social Work Responses to Domestic Violence During the COVID-19 Pandemic: Experiences and Perspectives of Professionals at Women's Shelters in Sweden.", "authors": [{"family": "Petersson", "given": "Charlotte C", "initials": "CC", "orcid": "0000-0002-2233-9297", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bef9293d9cfa49fb99a23232e1f8905e.json"}}, {"family": "Hansson", "given": "Kristofer", "initials": "K"}], "type": "journal article", "published": "2022-01-27", "journal": {"title": "Clin Soc Work J", "issn": "0091-1674", "issn-l": null, "volume": null, "issue": null, "pages": "1-12"}, "abstract": "This study explores how social work professionals at women's shelters in Sweden experience, understand, and are responding to domestic violence under the impact of the COVID-19 pandemic. A qualitative longitudinal research design was employed, and multiple semi-structured interviews were conducted with 14 professionals at women's shelters over a period of one year. The results are presented in three overall themes; (a) professional challenges due to increased needs, (b) professionals' adjustments to new circumstances, and (c) professionals' attributions regarding client barriers to help seeking. The results show diverse and changing experiences among the professionals as the pandemic progressed. Clients and professionals have shared the same collective trauma associated with the pandemic, which has affected the professionals' understanding of and response to domestic violence. The professionals understand both clients and themselves as being more vulnerable and susceptible to risk under these new circumstances. Social work adjustments focused on maintaining contact, reducing risk and prioritizing safety, which had both positive and negative consequences for both clients and professionals. The study concludes that the professionals coped with the uncertainty they experienced during the pandemic by relying on both their previous knowledge and work experience of domestic violence and their experience of sharing trauma with clients.", "doi": "10.1007/s10615-022-00833-3", "pmid": "35103027", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "833"}, {"db": "pmc", "key": "PMC8792516"}], "notes": [], "created": "2022-02-06T16:51:49.489Z", "modified": "2022-11-22T05:40:09.771Z"}, {"entity": "publication", "iuid": "393d6100ca964841b76331c427e6aa0c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/393d6100ca964841b76331c427e6aa0c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/393d6100ca964841b76331c427e6aa0c"}}, "title": "Risk factors for COVID-19-related death, hospitalization and intensive care: a population-wide study of all inhabitants in Stockholm.", "authors": [{"family": "Hergens", "given": "Maria-Pia", "initials": "MP"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "Haglund", "given": "Per", "initials": "P"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Lampa", "given": "Erik", "initials": "E"}, {"family": "Nederby-\u00d6hd", "given": "Joanna", "initials": "J"}, {"family": "\u00d6stlund", "given": "Maria Rotz\u00e9n", "initials": "MR"}, {"family": "Cars", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2022-01-27", "journal": {"title": "Eur J Epidemiol", "issn": "1573-7284", "issn-l": "0393-2990"}, "abstract": "Since the beginning of the Covid-19 pandemic, the scientific community has explored determinants of Covid 19 disease severity. However, the majority of studies are based on in-hospital patients with high risk of collider- or selection bias. The present investigation details risk factors associated with overall mortality, hospitalization and intensive care unit (ICU) admission in Covid-19 infections, with complete population coverage and high-resolution data on patient characteristics and comorbid conditions This population-based observational study comprises all residents 18 years and older in Stockholm Region-1.8 million inhabitants-using the real-time Covid-19 monitoring framework. The observation period lasted between March 1 to December 31, 2020. Hazard ratios (HR) for risk factors of Covid-19 disease severity were assessed using Cox proportional hazard models. In total, 3322 deaths, 11,508 hospitalizations and 1423 ICU-admissions related to Covid-19 occurred during the study period. Kidney failure, diabetes and obesity increased risk of mortality and so did heart failure and ischemic heart disease. However, atrial fibrillation and hypertension did not. Risk of hospitalization follow a similar pattern, whereas admission to intensive care differs; triage processes where clearly present as certain co-morbid conditions were associated with lower ICU admission. Observed differences in risk of mortality and hospitalization among patients with Covid 19 raise important questions about potentially protective comedication which will be further addressed using the real-time Covid-19 monitoring framework.", "doi": "10.1007/s10654-021-00840-7", "pmid": "35083602", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10654-021-00840-7"}, {"db": "pmc", "key": "PMC8791671"}], "notes": [], "created": "2022-01-31T11:48:07.605Z", "modified": "2022-01-31T11:48:07.617Z"}, {"entity": "publication", "iuid": "983a90975b164a94803529dc4a7b9691", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/983a90975b164a94803529dc4a7b9691.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/983a90975b164a94803529dc4a7b9691"}}, "title": "Humoral immunogenicity and tolerability of heterologous ChAd/BNT compared with homologous BNT/BNT and ChAd/ChAd SARS-CoV-2 vaccination in hemodialysis patients : A multicenter prospective observational study.", "authors": [{"family": "Haase", "given": "Michael", "initials": "M", "orcid": "0000-0001-8212-7416", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3d5795641ee4ff0ab46f79603ba5e73.json"}}, {"family": "Lesny", "given": "Paul", "initials": "P", "orcid": "0000-0003-3001-5257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fd70d53d0644bbca442128b4bbdd676.json"}}, {"family": "Anderson", "given": "Mark", "initials": "M"}, {"family": "Cloherty", "given": "Gavin", "initials": "G"}, {"family": "Stec", "given": "Michael", "initials": "M"}, {"family": "Haase-Fielitz", "given": "Anja", "initials": "A", "orcid": "0000-0001-6881-2249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/281cb6db938041329bca7a38c27e39cd.json"}}, {"family": "Haarhaus", "given": "Mathias", "initials": "M", "orcid": "0000-0001-8274-6356", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b32fbbc042844a8a43fa0ab3dda8557.json"}}, {"family": "Santos-Ara\u00fajo", "given": "Carla", "initials": "C"}, {"family": "Veiga", "given": "Pedro Mota", "initials": "PM"}, {"family": "Macario", "given": "Fernando", "initials": "F"}], "type": "journal article", "published": "2022-01-27", "journal": {"title": "J Nephrol", "issn": "1724-6059", "issn-l": null}, "abstract": "After the reports of severe adverse reactions to the AstraZeneca ChAdOx1-S-nCoV-19 vaccine, patients who had received one dose of ChAdOx1-S-nCoV-19 vaccine were recommended a second dose of Pfizer's BNT162b2 vaccine. In hemodialysis patients, we compared the humoral immunogenicity and tolerability of homologous vaccination with ChAdOx1-nCoV-19/ChAdOx1-nCoV-19 (ChAd/ChAd) and BNT162b2/BNT162b2 (BNT/BNT) with heterologous vaccination of first dose of ChAdOx1-nCoV-19 and a second dose with BNT162b2 (ChAd/BNT).\n\nIn a multicenter prospective observational study, SARS-CoV-2 spike-IgG antibody levels, Nucleocapsid-protein-IgG-antibodies, and vaccine tolerability were assessed 6 weeks after second SARS-CoV-2 vaccination in 137 hemodialysis patients and 24 immunocompetent medical personnel.\n\nIn COVID-19-na\u00efve hemodialysis patients, significantly higher median SARS-CoV-2-spike IgG levels were found after ChAd/BNT (N = 16) compared to BNT/BNT (N = 100) or ChAd/ChAd (N = 10) (1744 [25th-75th percentile 276-2840] BAU/mL versus 361 [25th-75th percentile 120-936] BAU/mL; p = 0.009; 1744 [25th-75th percentile 276-2840] BAU/mL versus 100 [25th-75th percentile 41-346] BAU/mL; p = 0.017, respectively). Vaccinated, COVID-19-na\u00efve medical personnel had median SARS-CoV-2 spike-IgG levels of 650 (25th-75th percentile 217-1402) BAU/mL and vaccinated hemodialysis patients with prior COVID-19 7047 (25th-75th percentile 685-10,794) BAU/mL (N = 11). In multivariable regression analysis, heterologous vaccination (ChAd/BNT) of COVID-19-na\u00efve hemodialysis patients was independently associated with SARS-CoV-2 spike-IgG levels. The first dose of ChAd and the second dose of BNT after the first vaccination with ChAd (heterologous vaccination, ChAd/BNT) were associated with more frequent but manageable side effects compared with homologous BNT.\n\nWithin the limitations of this study, heterologous vaccination with ChAd/BNT appears to induce stronger humoral immunity and more frequent but manageable side effects than homologous vaccination with BNT/BNT or with ChAd/ChAd in COVID-19-na\u00efve hemodialysis patients.", "doi": "10.1007/s40620-022-01247-7", "pmid": "35084719", "labels": {"Category: Health": null, "Category: Other": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40620-022-01247-7"}, {"db": "pmc", "key": "PMC8792133"}], "notes": [], "created": "2022-01-31T11:45:33.489Z", "modified": "2022-01-31T11:45:33.628Z"}, {"entity": "publication", "iuid": "0524427e04e14e1396474c73d00bf50d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0524427e04e14e1396474c73d00bf50d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0524427e04e14e1396474c73d00bf50d"}}, "title": "National identity predicts public health support during a global pandemic.", "authors": [{"family": "Van Bavel", "given": "Jay J", "initials": "JJ", "orcid": "0000-0002-2520-0442", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/344fbd5da7bc4259b3f70839f401c84c.json"}}, {"family": "Cichocka", "given": "Aleksandra", "initials": "A", "orcid": "0000-0003-1703-1586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0cc1202c8fb34d07952c7d99ab43bf87.json"}}, {"family": "Capraro", "given": "Valerio", "initials": "V"}, {"family": "Sj\u00e5stad", "given": "Hallgeir", "initials": "H", "orcid": "0000-0002-8730-1038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9d4b3d4379f4e3bb43607c0ef08f159.json"}}, {"family": "Nezlek", "given": "John B", "initials": "JB", "orcid": "0000-0003-4963-3637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab0b925a3d5b4c3d9f03d141757d41ba.json"}}, {"family": "Pavlovi\u0107", "given": "Tomislav", "initials": "T", "orcid": "0000-0002-4470-3715", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b5a5d7b53914f58ba60821e70539887.json"}}, {"family": "Alfano", "given": "Mark", "initials": "M", "orcid": "0000-0001-5879-8033", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9adf19b051647d19c86bc89ee440988.json"}}, {"family": "Gelfand", "given": "Michele J", "initials": "MJ"}, {"family": "Azevedo", "given": "Flavio", "initials": "F", "orcid": "0000-0001-9000-8513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7864cb0e9bf846d6b69a6a5bf65cbd91.json"}}, {"family": "Birtel", "given": "Mich\u00e8le D", "initials": "MD"}, {"family": "Cislak", "given": "Aleksandra", "initials": "A", "orcid": "0000-0002-9880-6947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37e0b6640a76467890fed6a7975b031c.json"}}, {"family": "Lockwood", "given": "Patricia L", "initials": "PL", "orcid": "0000-0001-7195-9559", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d77d4779b0ff456b906f2001dc3aa36f.json"}}, {"family": "Ross", "given": "Robert Malcolm", "initials": "RM", "orcid": "0000-0001-8711-1675", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49cb2e4d713844729ee7d64213f3cdbe.json"}}, {"family": "Abts", "given": "Koen", "initials": "K", "orcid": "0000-0001-8546-8347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9128fa7c6104fecabd5e4e52b1ce6ee.json"}}, {"family": "Agadullina", "given": "Elena", "initials": "E", "orcid": "0000-0002-1505-1412", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1d55ff13a5b4373abb3aca1376a41b9.json"}}, {"family": "Aruta", "given": "John Jamir Benzon", "initials": "JJB", "orcid": "0000-0003-4155-1063", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc1b14a0e89b4d9cb7f9c977e34a9a67.json"}}, {"family": "Besharati", "given": "Sahba Nomvula", "initials": "SN", "orcid": "0000-0003-2836-7982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8948fcda91f444f89cc8ddcfe4e489d9.json"}}, {"family": "Bor", "given": "Alexander", "initials": "A", "orcid": "0000-0002-2624-9221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/048bdb252beb4b2599b619f41ace6277.json"}}, {"family": "Choma", "given": "Becky L", "initials": "BL"}, {"family": "Crabtree", "given": "Charles David", "initials": "CD", "orcid": "0000-0001-5144-8671", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4437f3c146f4f649e796f32d01d6052.json"}}, {"family": "Cunningham", "given": "William A", "initials": "WA"}, {"family": "De", "given": "Koustav", "initials": "K", "orcid": "0000-0001-9562-0672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d6627eccf1d42baa44ed1ab89430f41.json"}}, {"family": "Ejaz", "given": "Waqas", "initials": "W", "orcid": "0000-0002-2492-4115", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0540fea51e3740068aa543e3e9bfd57e.json"}}, {"family": "Elbaek", "given": "Christian T", "initials": "CT", "orcid": "0000-0002-7039-4565", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a44f489ddccb4a208ec453424a471bfc.json"}}, {"family": "Findor", "given": "Andrej", "initials": "A", "orcid": 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{"family": "Vieira", "given": "Joana B", "initials": "JB"}, {"family": "von Sikorski", "given": "Christian", "initials": "C", "orcid": "0000-0002-3787-8277", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bacd3f29f5ff4a93a75fa018974f0d49.json"}}, {"family": "Walker", "given": "Alexander Cameron", "initials": "AC", "orcid": "0000-0003-1431-6770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e48ea603420489e9ad84494d2266981.json"}}, {"family": "Watermeyer", "given": "Jennifer", "initials": "J", "orcid": "0000-0001-7918-8832", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/361039a0f7cb4ad1ba265ac819f61df3.json"}}, {"family": "Wetter", "given": "Erik", "initials": "E"}, {"family": "Whillans", "given": "Ashley", "initials": "A", "orcid": "0000-0002-1726-6978", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/23afeb4b16404c9fbbb5aec95295e358.json"}}, {"family": "Willardt", "given": "Robin", "initials": "R", "orcid": "0000-0002-2495-3450", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5379e789ed5f4144a062b66ca92e60b7.json"}}, {"family": "Wohl", "given": "Michael J A", "initials": "MJA", "orcid": "0000-0001-6945-5562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/669ce114edff4deca4595eac19f30eda.json"}}, {"family": "W\u00f3jcik", "given": "Adrian Dominik", "initials": "AD", "orcid": "0000-0002-7073-6019", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b96aa00cd81f466599febb11c10a3a99.json"}}, {"family": "Wu", "given": "Kaidi", "initials": "K", "orcid": "0000-0001-6881-7437", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab83e58b6bcb415ea5079ac48c77dd7b.json"}}, {"family": "Yamada", "given": "Yuki", "initials": "Y", "orcid": "0000-0003-1431-568X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12d5285132e14b7bbca2607a084fb449.json"}}, {"family": "Yilmaz", "given": "Onurcan", "initials": "O", "orcid": "0000-0002-6094-7162", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/534f37d570044b1f885ebc4c7e9bab54.json"}}, {"family": "Yogeeswaran", "given": "Kumar", "initials": "K"}, {"family": "Ziemer", "given": "Carolin-Theresa", "initials": "CT", "orcid": "0000-0002-0794-7702", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8177b1e630c54506b665af61a4204f3c.json"}}, {"family": "Zwaan", "given": "Rolf A", "initials": "RA"}, {"family": "Boggio", "given": "Paulo S", "initials": "PS"}], "type": "journal article", "published": "2022-01-26", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "517", "issn-l": "2041-1723"}, "abstract": "Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N = 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r = -0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics.", "doi": "10.1038/s41467-021-27668-9", "pmid": "35082277", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-27668-9"}], "notes": [], "created": "2022-01-31T11:49:07.063Z", "modified": "2022-01-31T11:49:27.807Z"}, {"entity": "publication", "iuid": "c02cba320d9d41c1b0f2f13d26ac7fc9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c02cba320d9d41c1b0f2f13d26ac7fc9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c02cba320d9d41c1b0f2f13d26ac7fc9"}}, "title": "Investigating the current environmental situation in the Middle East and North Africa (MENA) region during the third wave of COVID-19 pandemic: urban vs. rural context.", "authors": [{"family": "Abouzid", "given": "Mohamed", "initials": "M"}, {"family": "El-Sherif", "given": "Dina M", "initials": "DM"}, {"family": "Al Naggar", "given": "Yahya", "initials": "Y"}, {"family": "Alshehri", "given": "Mohammed M", "initials": "MM"}, {"family": "Alothman", "given": "Shaima", "initials": "S"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}, {"family": "Trabelsi", "given": "Rayhana", "initials": "R"}, {"family": "Ibrahim", "given": "Osama Mohamed", "initials": "OM"}, {"family": "Temraz", "given": "Esraa Hamouda", "initials": "EH"}, {"family": "Buimsaedah", "given": "Ahmad", "initials": "A"}, {"family": "Aziz", "given": "Ibrahim Adel", "initials": "IA"}, {"family": "Alwan", "given": "Muhammad", "initials": "M"}, {"family": "Al Hasan", "given": "Nuha Hadi Jasim", "initials": "NHJ"}, {"family": "Ragab", "given": "Heba Nasser", "initials": "HN"}, {"family": "Koraiem", "given": "Abdullah Muhammed", "initials": "AM"}, {"family": "Ahmed", "given": "Mareb H", "initials": "MH"}, {"family": "Temraz", "given": "Heba Hamouda", "initials": "HH"}, {"family": "Madeeh", "given": "Alyaa Khaled", "initials": "AK"}, {"family": "Alshareif", "given": "Mohanned Osama", "initials": "MO"}, {"family": "Elkhafeefi", "given": "Fatimah Saad", "initials": "FS"}, {"family": "Badis", "given": "Imed-Eddine", "initials": "IE"}, {"family": "Abdelslam", "given": "Asmaa E", "initials": "AE"}, {"family": "Ali", "given": "Almajdoub Ali Mohammed", "initials": "AAM"}, {"family": "Kotni", "given": "Nour El Imene", "initials": "NEI"}, {"family": "Amer", "given": "Thuraya", "initials": "T"}], "type": "journal article", "published": "2022-01-26", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "177", "issn-l": null}, "abstract": "Coronavirus 2019 (COVID-19) pandemic led to a massive global socio-economic tragedy that has impacted the ecosystem. This paper aims to contextualize urban and rural environmental situations during the COVID-19 pandemic in the Middle East and North Africa (MENA) Region.\n\nAn online survey was conducted, 6770 participants were included in the final analysis, and 64% were females. The majority of the participants were urban citizens (74%). Over 50% of the urban residents significantly (p < 0.001) reported a reduction in noise, gathering in tourist areas, and gathering in malls and restaurants. Concerning the pollutants, most urban and rural areas have reported an increase in masks thrown in streets (69.49% vs. 73.22%, resp.; p = 0.003). Plastic bags and hospital waste also increased significantly with the same p-value of < 0.001 in urban areas compared with rural ones. The multifactorial logistic model for urban resident predictors achieved acceptable discrimination (AUROC = 0.633) according to age, crowdedness, noise and few pollutants.\n\nThe COVID-19 pandemic had a beneficial impact on the environment and at the same time, various challenges regarding plastic and medical wastes are rising which requires environmental interventions.", "doi": "10.1186/s12889-021-12313-3", "pmid": "35081927", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-12313-3"}, {"db": "pmc", "key": "PMC8790551"}], "notes": [], "created": "2022-01-31T11:49:45.217Z", "modified": "2022-01-31T11:49:45.246Z"}, {"entity": "publication", "iuid": "dd12a80548b54077976f107f7b65cf6d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dd12a80548b54077976f107f7b65cf6d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dd12a80548b54077976f107f7b65cf6d"}}, "title": "Computational Analysis Reveals Monomethylated Triazolopyrimidine as a Novel Inhibitor of SARS-CoV-2 RNA-Dependent RNA Polymerase (RdRp).", "authors": [{"family": "Karthic", "given": "Anandakrishnan", "initials": "A"}, {"family": "Kesarwani", "given": "Veerbhan", "initials": "V", "orcid": "0000-0001-5778-6831", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c0f527583f94625bb9d2106104fb7d2.json"}}, {"family": "Singh", "given": "Rahul Kunwar", "initials": "RK", "orcid": "0000-0003-3630-5706", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02f5d3fe155541d1b88e8c90ba420ab3.json"}}, {"family": "Yadav", "given": "Pavan Kumar", "initials": "PK"}, {"family": "Chaturvedi", "given": "Navaneet", "initials": "N", "orcid": "0000-0002-4265-9255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b6f5bf7d4ff4477b7e35faac4df684c.json"}}, {"family": "Chauhan", "given": "Pallavi", "initials": "P", "orcid": "0000-0002-5160-6673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6f59a01303e4493393dbe2fba6b2e8f7.json"}}, {"family": "Yadav", "given": "Brijesh Singh", "initials": "BS"}, {"family": "Kushwaha", "given": "Sandeep Kumar", "initials": "SK"}], "type": "journal article", "published": "2022-01-26", "journal": {"title": "Molecules", "issn": "1420-3049", "volume": "27", "issue": "3", "issn-l": null}, "abstract": "The human population is still facing appalling conditions due to several outbreaks of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus. The absence of specific drugs, appropriate vaccines for mutants, and knowledge of potential therapeutic agents makes this situation more difficult. Several 1, 2, 4-triazolo [1, 5-a] pyrimidine (TP)-derivative compounds were comprehensively studied for antiviral activities against RNA polymerase of HIV, HCV, and influenza viruses, and showed immense pharmacological interest. Therefore, TP-derivative compounds can be repurposed against the RNA-dependent RNA polymerase (RdRp) protein of SARS-CoV-2. In this study, a meta-analysis was performed to ensure the genomic variability and stability of the SARS-CoV-2 RdRp protein. The molecular docking of natural and synthetic TP compounds to RdRp and molecular dynamic (MD) simulations were performed to analyse the dynamic behaviour of TP compounds at the active site of the RdRp protein. TP compounds were also docked against other non-structural proteins (NSP1, NSP2, NSP3, NSP5, NSP8, NSP13, and NSP15) of SARS-CoV-2. Furthermore, the inhibition potential of TP compounds was compared with Remdesivir and Favipiravir drugs as a positive control. Additionally, TP compounds were analysed for inhibitory activity against SARS-CoV RdRp protein. This study demonstrates that TP analogues (monomethylated triazolopyrimidine and essramycin) represent potential lead molecules for designing an effective inhibitor to control viral replication. Furthermore, in vitro and in vivo studies will strengthen the use of these inhibitors as suitable drug candidates against SARS-CoV-2.", "doi": "10.3390/molecules27030801", "pmid": "35164069", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "molecules27030801"}], "notes": [], "created": "2022-02-17T06:08:36.632Z", "modified": "2022-02-17T06:09:00.719Z"}, {"entity": "publication", "iuid": "cf59a3c7e7c34226b242a79239cb1c2b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cf59a3c7e7c34226b242a79239cb1c2b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cf59a3c7e7c34226b242a79239cb1c2b"}}, "title": "Living conditions, lifestyle habits and health among adults before and after the COVID-19 pandemic outbreak in Sweden - results from a cross-sectional population-based study.", "authors": [{"family": "Molarius", "given": "Anu", "initials": "A"}, {"family": "Persson", "given": "Carina", "initials": "C"}], "type": "journal article", "published": "2022-01-25", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "171", "issn-l": null}, "abstract": "Studies on the public health consequences of COVID-19 pandemic showing data based on robust methods are scarce. The aim of this study was to investigate mental and physical health as well as living conditions and lifestyle habits in the general population before and after the COVID-19 outbreak in Sweden.\n\nThe study is based on 2273 persons 16-84 years who responded to the national public health survey in February-May 2020 in V\u00e4rmland county (overall response rate 45%). The differences between early respondents (before the outbreak, n = 1711) and late respondents (after the outbreak, n = 562) were studied using multivariate logistic regression, adjusting for background characteristics: age, gender, educational level, and country of birth. The same analyses were also completed in the corresponding survey carried out in February-June 2018.\n\nStatistically significant differences between the groups were obtained for economic difficulties and worry about losing one's job, which were more common among late respondents, and for sleeping difficulties, which were more common among early respondents after adjusting for background characteristics. There were no differences in other living conditions nor in lifestyle factors. Prevalence of good self-rated health, high blood pressure, aches in shoulders or neck, anxiety or worry and stress did not differ between the groups. In 2018, the only statistically significant difference between early and late respondents concerned economic difficulties.\n\nVery few differences in living conditions, lifestyle factors and health were observed in the study population before and after the COVID-19 outbreak. The results suggest that, in addition to a possible decrease in sleeping difficulties, the prevalence of being worried about losing one's job increased among the employed after the outbreak.", "doi": "10.1186/s12889-021-12315-1", "pmid": "35078430", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-12315-1"}, {"db": "pmc", "key": "PMC8787439"}], "notes": [], "created": "2022-01-27T06:59:44.489Z", "modified": "2022-01-31T11:50:19.633Z"}, {"entity": "publication", "iuid": "84fdbc5f70264da68f79b41a55046bae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84fdbc5f70264da68f79b41a55046bae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84fdbc5f70264da68f79b41a55046bae"}}, "title": "Effectiveness of tobacco cessation interventions for different groups of tobacco users in Sweden: a study protocol for a national prospective cohort study.", "authors": [{"family": "Rasmussen", "given": "Mette", "initials": "M", "orcid": "0000-0003-2847-1544", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/155367945a2f4bb186320d69eea6a117.json"}}, {"family": "Larsson", "given": "Matz", "initials": "M"}, {"family": "Gilljam", "given": "Hans", "initials": "H"}, {"family": "Adami", "given": "Johanna", "initials": "J"}, {"family": "W\u00e4rjerstam", "given": "Sanne", "initials": "S"}, {"family": "Post", "given": "Ann", "initials": "A"}, {"family": "Bj\u00f6rk-Eriksson", "given": "Thomas", "initials": "T"}, {"family": "Helgason", "given": "Asgeir R", "initials": "AR"}, {"family": "T\u00f8nnesen", "given": "Hanne", "initials": "H"}], "type": "journal article", "published": "2022-01-25", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "1", "pages": "e053090", "issn-l": "2044-6055"}, "abstract": "Tobacco is still one of the single most important risk factors among the lifestyle habits that cause morbidity and mortality in humans. Furthermore, tobacco has a heavy social gradient, as the consequences are even worse among disadvantaged and vulnerable groups. To reduce tobacco-related inequity in health, those most in need should be offered the most effective tobacco cessation intervention. The aim of this study is to facilitate and improve the evaluation of already implemented national tobacco cessation efforts, focusing on 10 disadvantaged and vulnerable groups of tobacco users.\n\nThis is a prospective cohort study. Data will be collected by established tobacco cessation counsellors in Sweden. The study includes adult tobacco or e-cigarette users, including disadvantaged and vulnerable patients, receiving in-person interventions for tobacco or e-cigarette cessation (smoking, snus and/or e-cigarettes). Patient inclusion was initiated in April 2020. For data analyses patients will be sorted into vulnerable groups based on risk factors and compared with tobacco users without the risk factor in question.The primary outcome is continuous successful quitting after 6 months, measured by self-reporting. Secondary outcomes include abstinence at the end of the treatment programme, which could be from minutes over days to weeks, 14-day point prevalence after 6 months, and patient satisfaction with the intervention. Effectiveness of successful quitting will be examined by comparing vulnerable with non-vulnerable patients using a mixed-effect logistic regression model adjusting for potential prognostic factors and known confounders.\n\nThe project will follow the guidelines from the Swedish Data Protection Authority and have been approved by the Swedish Ethical Review Authority before patient inclusion (Dnr: 2019-02221). Only patients providing written informed consent will be included. Both positive and negative results will be published in scientific peer-reviewed journals and presented at national and international conferences. Information will be provided through media available to the public, politicians, healthcare providers and planners as these are all important stakeholders.\n\nNCT04819152.", "doi": "10.1136/bmjopen-2021-053090", "pmid": "35078840", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-053090"}, {"db": "ClinicalTrials.gov", "key": "NCT04819152"}], "notes": [], "created": "2022-01-27T06:59:16.941Z", "modified": "2022-01-31T11:50:05.070Z"}, {"entity": "publication", "iuid": "b6b72a9a8e9f447b858546ce4f87518e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b6b72a9a8e9f447b858546ce4f87518e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b6b72a9a8e9f447b858546ce4f87518e"}}, "title": "Correction for Rando et al., \"Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure\".", "authors": [{"family": "Rando", "given": "Halie M", "initials": "HM", "orcid": "0000-0001-7688-1770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b5a9f4ec1bd48579abca9895dab3ea7.json"}}, {"family": "MacLean", "given": "Adam L", "initials": "AL", "orcid": "0000-0003-0689-7907", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c26b86f5b6704c6bb26549e40cb2a1a6.json"}}, {"family": "Lee", "given": "Alexandra J", "initials": "AJ", "orcid": "0000-0002-0208-3730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/761782ce14b542078b3ee6c0db2bb6ce.json"}}, {"family": "Lordan", "given": "Ronan", "initials": "R", "orcid": "0000-0001-9668-3368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0126a49dfcdf49fcb53041fbdcd91706.json"}}, {"family": "Ray", "given": "Sandipan", "initials": "S", "orcid": "0000-0002-9960-5768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa10e3ee0fd54ba493cbe4cca8fc6eff.json"}}, {"family": "Bansal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-0944-7226", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae5fbe58965d4d2ca9051acb7d654def.json"}}, {"family": "Skelly", "given": "Ashwin N", "initials": "AN", "orcid": "0000-0002-1565-3376", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9818ecec2a65431faf931d73ea71bcb2.json"}}, {"family": "Sell", "given": "Elizabeth", "initials": "E", "orcid": "0000-0002-9658-1107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8da837618164c6e95e39ec75771917c.json"}}, {"family": "Dziak", "given": "John J", "initials": "JJ", "orcid": "0000-0003-0762-5495", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7cab03612a54c61b5f336726df5fd86.json"}}, {"family": "Shinholster", "given": "Lamonica", "initials": "L", "orcid": "0000-0001-6285-005X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/55c5da8c3c764c3fbc5877f15931f19b.json"}}, {"family": "D'Agostino McGowan", "given": "Lucy", "initials": "L", "orcid": "0000-0001-7297-9359", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eaf0882d7094646bd20be91a897cf8f.json"}}, {"family": "Ben Guebila", "given": "Marouen", "initials": "M", "orcid": "0000-0001-5934-966X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e04fc9008f7f4307a76515f913f19adf.json"}}, {"family": "Wellhausen", "given": "Nils", "initials": "N", "orcid": "0000-0001-8955-7582", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/934767f0228241648d70c7b00527deff.json"}}, {"family": "Knyazev", "given": "Sergey", "initials": "S", "orcid": "0000-0003-0385-1831", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5191e5ac40f244369f156171f69b6043.json"}}, {"family": "Boca", "given": "Simina M", "initials": "SM", "orcid": "0000-0002-1400-3398", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3eb0ffeffea24d5cb745b5ca86648e60.json"}}, {"family": "Capone", "given": "Stephen", "initials": "S", "orcid": "0000-0001-7231-1535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e5465fb84654d2d8edc152bc1fabb0a.json"}}, {"family": "Qi", "given": "Yanjun", "initials": "Y", "orcid": "0000-0002-5796-7453", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d48badb4eff4f4f9bf3f15632f0c3a7.json"}}, {"family": "Park", "given": "YoSon", "initials": "Y", "orcid": "0000-0002-0465-4744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d3c095fe591449a8c122645bf540ed5.json"}}, {"family": "Mai", "given": "David", "initials": "D", "orcid": "0000-0002-9238-0164", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c9a0a9f7fd0402b889577876833cb01.json"}}, {"family": "Sun", "given": "Yuchen", "initials": "Y"}, {"family": "Boerckel", "given": "Joel D", "initials": "JD", "orcid": "0000-0003-3126-3025", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c5b796936cf42d7a3ea63f54266f680.json"}}, {"family": "Brueffer", "given": "Christian", "initials": "C", "orcid": "0000-0002-3826-0989", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c4f95c1889f4f098676404aec6125ca.json"}}, {"family": "Byrd", "given": "James Brian", "initials": "JB", "orcid": "0000-0002-0509-3520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bc319c5d0d74676875bd9ff266f5e80.json"}}, {"family": "Kamil", "given": "Jeremy P", "initials": "JP", "orcid": "0000-0001-8422-7656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa225803435a4d7b803176e2ccfbef19.json"}}, {"family": "Wang", "given": "Jinhui", "initials": "J", "orcid": "0000-0002-5796-8130", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5243fdc11744ba89697e8fdf9c2feee.json"}}, {"family": "Velazquez", "given": "Ryan", "initials": "R", "orcid": "0000-0002-3655-3403", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32443d060ec043e59e1683db8be8a2f0.json"}}, {"family": "Szeto", "given": "Gregory L", "initials": "GL", "orcid": "0000-0001-7604-1333", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ca2a47e8bce54293918ec2bec05b0cd0.json"}}, {"family": "Barton", "given": "John P", "initials": "JP", "orcid": "0000-0003-1467-421X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae8b1b4348b5476fa268c2079c6b9c7d.json"}}, {"family": "Goel", "given": "Rishi Raj", "initials": "RR", "orcid": "0000-0003-1715-5191", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ad2f4cb84774051bb9422f314ec0f11.json"}}, {"family": "Mangul", "given": "Serghei", "initials": "S", "orcid": "0000-0003-4770-3443", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dbe15e382e84d38a0fd859377e39d47.json"}}, {"family": "Lubiana", "given": "Tiago", "initials": "T", "orcid": "0000-0003-2473-2313", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/132869d486e241dda1448ef1448ab83c.json"}}, {"family": "COVID-19 Review Consortium", "given": "", "initials": ""}, {"family": "Gitter", "given": "Anthony", "initials": "A", "orcid": "0000-0002-5324-9833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7085c8743e3442859ad6f23198c85456.json"}}, {"family": "Greene", "given": "Casey S", "initials": "CS", "orcid": "0000-0001-8713-9213", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42aaaac8b65642538f28f9cd2045ab8d.json"}}], "type": "journal article", "published": "2022-01-25", "journal": {"title": "mSystems", "issn": "2379-5077", "pages": "e0144721", "issn-l": null}, "abstract": null, "doi": "10.1128/msystems.01447-21", "pmid": "35076276", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2022-01-26T08:23:59.651Z", "modified": "2022-01-26T08:24:00.210Z"}, {"entity": "publication", "iuid": "bafbb26351e0441bafd8aa7de38cd297", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bafbb26351e0441bafd8aa7de38cd297.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bafbb26351e0441bafd8aa7de38cd297"}}, "title": "A patient satisfaction survey and educational package to improve the care of people hospitalised with COVID-19: a quality improvement project, Liverpool, UK.", "authors": [{"family": "Ahmad", "given": "Muhammad Shamsher", "initials": "MS"}, {"family": "Hicks", "given": "Scott Rory", "initials": "SR"}, {"family": "Watson", "given": "Rebecca", "initials": "R"}, {"family": "Ahmed", "given": "Rajia Akter", "initials": "RA"}, {"family": "Jones", "given": "Lewis", "initials": "L"}, {"family": "Vaselli", "given": "Marcella", "initials": "M"}, {"family": "Wu", "given": "Meng-San", "initials": "MS"}, {"family": "Hayat", "given": "Fatima", "initials": "F"}, {"family": "Ratcliffe", "given": "Libuse", "initials": "L"}, {"family": "McKenna", "given": "Mark", "initials": "M"}, {"family": "Hine", "given": "Paul", "initials": "P"}, {"family": "Defres", "given": "Sylviane", "initials": "S"}, {"family": "Wingfield", "given": "Tom", "initials": "T"}], "type": "journal article", "published": "2022-01-25", "journal": {"title": "Wellcome Open Res", "issn": "2398-502X", "volume": "6", "pages": "222", "issn-l": null}, "abstract": "Background: The perspectives and experiences of people hospitalised with COVID-19 have been under-reported during the coronavirus pandemic. We developed and conducted a COVID-19 patient satisfaction survey in a large university-affiliated secondary healthcare centre in Liverpool, UK, during Europe's first coronavirus wave (April-June 2020). The survey found that care was rated highly, including among people of Black Asian and Minority Ethnic (BAME) backgrounds. However, sleep-quality and communication about medications and discharge-planning were identified as areas for improvement. Methods: To improve care for people with COVID-19 admitted to our centre, we designed an educational package for healthcare professionals working on COVID-19 wards. The package, implemented in August 2020, included healthcare worker training sessions on providing holistic care and placement of \"Practice Pointers\" posters. Patient satisfaction was re-evaluated during the second/third COVID-19 waves in Liverpool (September 2020 - February 2021). Results: Across waves, most (95%) respondents reported that they would recommend our hospital to friends and/or family and rated overall care highly. Comparison of the responses of second/third-wave respondents (n=101) with first-wave respondents (n=94) suggested improved patient satisfaction across most care domains but especially those related to having worries and fears addressed and being consulted about medications and their side-effects. Conclusions: People admitted with COVID-19 to our centre in Liverpool, including those from BAME backgrounds, rated the care they received highly. A simple education package improved the feedback on care received by respondents between the first and second/third waves. These UK-first findings are informing regional strategies to improve person-centred care of hospitalised people with COVID-19.", "doi": "10.12688/wellcomeopenres.17163.2", "pmid": "35118199", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8787571.2"}], "notes": [], "created": "2022-02-06T16:46:17.605Z", "modified": "2022-02-08T15:17:21.605Z"}, {"entity": "publication", "iuid": "4b540bc2f54746448d5bdbf914ca7561", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b540bc2f54746448d5bdbf914ca7561.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b540bc2f54746448d5bdbf914ca7561"}}, "title": "The importance of accessory protein variants in the pathogenicity of SARS-CoV-2.", "authors": [{"family": "Hassan", "given": "Sk Sarif", "initials": "SS"}, {"family": "Choudhury", "given": "Pabitra Pal", "initials": "PP"}, {"family": "Dayhoff", "given": "Guy W", "initials": "GW"}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA"}, {"family": "Uhal", "given": "Bruce D", "initials": "BD"}, {"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Pizzol", "given": "Damiano", "initials": "D"}, {"family": "Adadi", "given": "Parise", "initials": "P"}, {"family": "Lal", "given": "Amos", "initials": "A"}, {"family": "Soares", "given": "Antonio", "initials": "A"}, {"family": "Mohamed Abd El-Aziz", "given": "Tarek", "initials": "T"}, {"family": "Brufsky", "given": "Adam M", "initials": "AM"}, {"family": "Azad", "given": "Gajendra Kumar", "initials": "GK"}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Baetas-da-Cruz", "given": "Wagner", "initials": "W"}, {"family": "Takayama", "given": "Kazuo", "initials": "K"}, {"family": "Serrano-Aroca", "given": "\u00c3ngel", "initials": "\u00c3"}, {"family": "Chauhan", "given": "Gaurav", "initials": "G"}, {"family": "Palu", "given": "Giorgio", "initials": "G"}, {"family": "Mishra", "given": "Yogendra Kumar", "initials": "YK"}, {"family": "Barh", "given": "Debmalya", "initials": "D"}, {"family": "Santana Silva", "given": "Raner Jo\u015be", "initials": "RJ"}, {"family": "Andrade", "given": "Bruno Silva", "initials": "BS"}, {"family": "Azevedo", "given": "Vasco", "initials": "V"}, {"family": "G\u00f3es-Neto", "given": "Arist\u00f3teles", "initials": "A"}, {"family": "Bazan", "given": "Nicolas G", "initials": "NG"}, {"family": "Redwan", "given": "Elrashdy M", "initials": "EM"}, {"family": "Tambuwala", "given": "Murtaza", "initials": "M"}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN"}], "type": "journal article", "published": "2022-01-24", "journal": {"title": "Arch Biochem Biophys", "issn": "1096-0384", "volume": "717", "pages": "109124", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 possess putative functions to manipulate host immune mechanisms. These involve interferons, which appear as a consensus function, immune signaling receptor NLRP3 (NLR family pyrin domain-containing 3) inflammasome, and inflammatory cytokines such as interleukin 1\u03b2 (IL-1\u03b2) and are critical in COVID-19 pathology. Outspread variations of each of the six accessory proteins were observed across six continents of all complete SARS-CoV-2 proteomes based on the data reported before November 2020. A decreasing order of percentage of unique variations in the accessory proteins was determined as ORF3a > ORF8 > ORF7a > ORF6 > ORF10 > ORF7b across all continents. The highest and lowest unique variations of ORF3a were observed in South America and Oceania, respectively. These findings suggest that the wide variations in accessory proteins seem to affect the pathogenicity of SARS-CoV-2.", "doi": "10.1016/j.abb.2022.109124", "pmid": "35085577", "labels": {"Category: Health": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0003-9861(22)00009-1"}, {"db": "pmc", "key": "PMC8785432"}], "notes": [], "created": "2022-01-31T11:45:10.498Z", "modified": "2022-01-31T11:45:10.533Z"}, {"entity": "publication", "iuid": "5f5d5f35bd3b4786b8079a511e0db6fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f5d5f35bd3b4786b8079a511e0db6fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f5d5f35bd3b4786b8079a511e0db6fd"}}, "title": "Large gaps in the quality of healthcare experienced by Swedish mothers during the COVID-19 pandemic: A cross-sectional study based on WHO standards.", "authors": [{"family": "Zaigham", "given": "Mehreen", "initials": "M"}, {"family": "Linden", "given": "Karolina", "initials": "K"}, {"family": "Sengpiel", "given": "Verena", "initials": "V"}, {"family": "Mariani", "given": "Ilaria", "initials": "I"}, {"family": "Valente", "given": "Emanuelle Pessa", "initials": "EP"}, {"family": "Covi", "given": "Benedetta", "initials": "B"}, {"family": "Lazzerini", "given": "Marzia", "initials": "M"}, {"family": "Elden", "given": "Helen", "initials": "H"}, {"family": "IMAgiNE EURO Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-01-24", "journal": {"title": "Women Birth", "issn": "1878-1799", "issn-l": null}, "abstract": "Existing healthcare systems have been put under immense pressure during the COVID-19 pandemic. Disruptions in essential maternal and newborn services have come from even high-income countries within the World Health Organization (WHO) European Region.\n\nTo describe the quality of care during pregnancy and childbirth, as reported by the women themselves, during the COVID-19 pandemic in Sweden, using the WHO 'Standards for improving quality of maternal and newborn care in health facilities'.\n\nUsing an anonymous, online questionnaire, women \u226518 years were invited to participate if they had given birth in Sweden from March 1, 2020 to June 30, 2021. The quality of maternal and newborn care was measured using 40 questions across four domains: provision of care, experience of care, availability of human/physical resources, and organisational changes due to COVID-19.\n\nOf the 5003 women included, n = 4528 experienced labour. Of these, 46.7% perceived a poorer quality of maternal and newborn care due to the COVID-19. Fundal pressure was applied in 22.2% of instrumental vaginal births, 36.8% received inadequate breastfeeding support and 6.9% reported some form of abuse. Findings were worse in women undergoing prelabour Caesarean section (CS) (n = 475). Multivariate analysis showed significant associations of the quality of maternal and newborn care to year of birth (P < 0.001), parity (P < 0.001), no pharmacological pain relief (P < 0.001), prelabour CS (P < 0.001), emergency CS (P < 0.001) and overall satisfaction (P < 0.001).\n\nConsiderable gaps over many key quality measures and deviations from women-centred care were noted. Findings were worse in women with prelabour CS. Actions to promote high-quality, evidence-based and respectful care during childbirth for all mothers are urgently needed.", "doi": "10.1016/j.wombi.2022.01.007", "pmid": "35123922", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1871-5192(22)00010-5"}], "notes": [], "created": "2022-02-08T15:16:44.040Z", "modified": "2022-02-08T15:16:44.074Z"}, {"entity": "publication", "iuid": "6ca32244d0bc40a1b1fe81f99ab27022", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ca32244d0bc40a1b1fe81f99ab27022.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ca32244d0bc40a1b1fe81f99ab27022"}}, "title": "Job satisfaction and challenges of working from home during the COVID-19 pandemic: A study in a Swedish academic setting.", "authors": [{"family": "Zandi", "given": "Saeid", "initials": "S"}, {"family": "Ahmadi", "given": "Fereshteh", "initials": "F"}, {"family": "Cetrez", "given": "\u00d6nver Andreas", "initials": "\u00d6A"}, {"family": "Akhavan", "given": "Sharareh", "initials": "S"}], "type": "journal article", "published": "2022-01-24", "journal": {"title": "Work", "issn": "1875-9270", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic changed the academic world in various ways, and most universities are still closed and continue operating via teleworking.\r\n\r\nThis study is intended to investigate how university faculty/staff and students in Sweden have coped with the lockdown and working/studying from home during the pandemic.\r\n\r\nA survey was conducted among 277 women and men working and studying at different universities in Sweden.\r\n\r\nThe results indicate that most (61%) respondents were very or somewhat satisfied with the current work-from-home arrangement. Additionally, they indicate that, overall, almost 30% were working more than usual due to the pandemic and teleworking. The coping methods having the highest impact on overall job satisfaction were: \"thinking about what I can do rather than what I can't do\"; \"being able to access medical resources and medical services if I need to seek help\"; and \"having trust in state or health authorities in my country.\"\r\n\r\nThe study reveals that Sweden can serve as a good example of how university faculty/staff and students can address the occupational challenges caused by a health pandemic and possible subsequent quarantines.", "doi": "10.3233/WOR-210442", "pmid": "35095001", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "WOR210442"}], "notes": [], "created": "2022-02-06T17:03:51.861Z", "modified": "2022-11-22T05:40:30.241Z"}, {"entity": "publication", "iuid": "a72928556fb247c2bef359ecfeea0219", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a72928556fb247c2bef359ecfeea0219.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a72928556fb247c2bef359ecfeea0219"}}, "title": "Effects of the Early Phase of COVID-19 on the Autistic Community in Sweden: A Qualitative Multi-Informant Study Linking to ICF.", "authors": [{"family": "Fridell", "given": "Anna", "initials": "A"}, {"family": "Norrman", "given": "Hjalmar Nobel", "initials": "HN"}, {"family": "Girke", "given": "Linda", "initials": "L"}, {"family": "B\u00f6lte", "given": "Sven", "initials": "S"}], "type": "journal article", "published": "2022-01-24", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "3", "issn-l": null}, "abstract": "While the COVID-19 pandemic is ongoing, early outcome studies indicate severe and pervasive global effects of the pandemic and associated measures to prevent the spread of the virus. General population studies, as well as insight into the outcomes for particular groups, will be necessary in order to mitigate potentially long-term effects as well as to prepare for future epidemics or pandemics. The pandemic conditions have been marked by rapid and abrupt changes and unpredictability which are circumstances that leave the autistic population particularly vulnerable to adverse outcomes following the distinctive features of the diagnosis. Studies are only beginning to delineate the outcomes of the global autism community and the present study adds to these findings by providing a local, multi-perspective, qualitative analysis of the lived experiences of the Swedish autism community. In this study, autistic youth and adults, caregivers of autistic individuals, as well as representatives of Swedish interest organizations were interviewed. Thematic analysis was performed on the population as a whole and patterns of results were formalized according to the International Classification of Function, Disability and Health (ICF-CY). Participants report wide-ranging adverse outcomes of the pandemic relating to mental health and access to support, participation in daily activities and socialization, education, and work as well as parental resources. However, participants also report positive outcomes relating to a reduction in specific social and everyday demands, and normalization of lived experiences. Additionally, interviews outlined some strategies used to cope during pandemic conditions. Implications of these findings are discussed.", "doi": "10.3390/ijerph19031268", "pmid": "35162290", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph19031268"}], "notes": [], "created": "2022-02-17T06:09:37.469Z", "modified": "2022-02-17T06:09:37.480Z"}, {"entity": "publication", "iuid": "232f63dad3c74e8d88722bbe6132904e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/232f63dad3c74e8d88722bbe6132904e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/232f63dad3c74e8d88722bbe6132904e"}}, "title": "A Model Predicting Mortality of Hospitalized Covid-19 Patients Four Days After Admission: Development, Internal and Temporal-External Validation.", "authors": [{"family": "Heber", "given": "Stefan", "initials": "S"}, {"family": "Pereyra", "given": "David", "initials": "D"}, {"family": "Schrottmaier", "given": "Waltraud C", "initials": "WC"}, {"family": "Kammerer", "given": "Kerstin", "initials": "K"}, {"family": "Santol", "given": "Jonas", "initials": "J"}, {"family": "Rumpf", "given": "Benedikt", "initials": "B"}, {"family": "Pawelka", "given": "Erich", "initials": "E"}, {"family": "Hanna", "given": "Markus", "initials": "M"}, {"family": "Scholz", "given": "Alexander", "initials": "A"}, {"family": "Liu", "given": "Markus", "initials": "M"}, {"family": "Hell", "given": "Agnes", "initials": "A"}, {"family": "Heiplik", "given": "Klara", "initials": "K"}, {"family": "Lickefett", "given": "Benno", "initials": "B"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Traugott", "given": "Marianna T", "initials": "MT"}, {"family": "Neub\u00f6ck", "given": "Matthias J", "initials": "MJ"}, {"family": "Sch\u00f6rgenhofer", "given": "Christian", "initials": "C"}, {"family": "Seitz", "given": "Tamara", "initials": "T"}, {"family": "Firbas", "given": "Christa", "initials": "C"}, {"family": "Karolyi", "given": "Mario", "initials": "M"}, {"family": "Weiss", "given": "G\u00fcnter", "initials": "G"}, {"family": "Jilma", "given": "Bernd", "initials": "B"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Bellmann-Weiler", "given": "Rosa", "initials": "R"}, {"family": "Salzer", "given": "Helmut J F", "initials": "HJF"}, {"family": "Szepannek", "given": "Gero", "initials": "G"}, {"family": "Fischer", "given": "Michael J M", "initials": "MJM"}, {"family": "Zoufaly", "given": "Alexander", "initials": "A"}, {"family": "Gleiss", "given": "Andreas", "initials": "A"}, {"family": "Assinger", "given": "Alice", "initials": "A"}], "type": "journal article", "published": "2022-01-24", "journal": {"title": "Front Cell Infect Microbiol", "issn": "2235-2988", "volume": "11", "pages": "795026", "issn-l": null}, "abstract": "To develop and validate a prognostic model for in-hospital mortality after four days based on age, fever at admission and five haematological parameters routinely measured in hospitalized Covid-19 patients during the first four days after admission.\n\nHaematological parameters measured during the first 4 days after admission were subjected to a linear mixed model to obtain patient-specific intercepts and slopes for each parameter. A prediction model was built using logistic regression with variable selection and shrinkage factor estimation supported by bootstrapping. Model development was based on 481 survivors and 97 non-survivors, hospitalized before the occurrence of mutations. Internal validation was done by 10-fold cross-validation. The model was temporally-externally validated in 299 survivors and 42 non-survivors hospitalized when the Alpha variant (B.1.1.7) was prevalent.\n\nThe final model included age, fever on admission as well as the slope or intercept of lactate dehydrogenase, platelet count, C-reactive protein, and creatinine. Tenfold cross validation resulted in a mean area under the receiver operating characteristic curve (AUROC) of 0.92, a mean calibration slope of 1.0023 and a Brier score of 0.076. At temporal-external validation, application of the previously developed model showed an AUROC of 0.88, a calibration slope of 0.95 and a Brier score of 0.073. Regarding the relative importance of the variables, the (apparent) variation in mortality explained by the six variables deduced from the haematological parameters measured during the first four days is higher (explained variation 0.295) than that of age (0.210).\n\nThe presented model requires only variables routinely acquired in hospitals, which allows immediate and wide-spread use as a decision support for earlier discharge of low-risk patients to reduce the burden on the health care system.\n\nAustrian Coronavirus Adaptive Clinical Trial (ACOVACT); ClinicalTrials.gov, identifier NCT04351724.", "doi": "10.3389/fcimb.2021.795026", "pmid": "35141170", "labels": {"Category: Health": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pmc", "key": "PMC8819729"}, {"db": "ClinicalTrials.gov", "key": "NCT04351724"}], "notes": [], "created": "2022-02-11T10:22:45.318Z", "modified": "2022-02-11T10:23:22.712Z"}, {"entity": "publication", "iuid": "9b7b92f7ea4d4787ad56daa4bc4e4930", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b7b92f7ea4d4787ad56daa4bc4e4930.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b7b92f7ea4d4787ad56daa4bc4e4930"}}, "title": "Predictive performance and clinical application of COV50, a urinary proteomic biomarker in early COVID-19 infection: a cohort study", "authors": [{"family": "Staessen", "given": "Jan A", "initials": "JA"}, {"family": "Wendt", "given": "Ralph", "initials": "R"}, {"family": "Yu", "given": "Yu Ling", "initials": "YL"}, {"family": "Thijs", "given": "Lutgarde", "initials": "L"}, {"family": "Siwy", "given": "Justyna", "initials": "J"}, {"family": "Raad", "given": "Julia", "initials": "J"}, {"family": "Metzger", "given": "Jochen", "initials": "J"}, {"family": "Neuhaus", "given": "Barbara", "initials": "B"}, {"family": "Papkalla", "given": "Armin", "initials": "A"}, {"family": "von der Leyen", "given": "Heiko", "initials": "H"}, {"family": "Mebazaa", "given": "Alexandre", "initials": "A"}, {"family": "Dudoignon", "given": "Emmanual", "initials": "E"}, {"family": "Spasovski", "given": "Goce", "initials": "G"}, {"family": "Milenkova", "given": "Mimoza", "initials": "M"}, {"family": "Canevska-Taneska", "given": "Aleksandra", "initials": "A"}, {"family": "Psichogiou", "given": "Mina", "initials": "M"}, {"family": "Rajzer", "given": "Marke W", "initials": "MW"}, {"family": "Fulawka", "given": "Lukasz", "initials": "L"}, {"family": "Dzitkowska-Zabielska", "given": "Magdalena", "initials": "M"}, {"family": "Weiss", "given": "Guenter", "initials": "G"}, {"family": "Feldt", "given": "Torsten", "initials": "T"}, {"family": "Stegemann", "given": "Miriam", "initials": "M"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Zoufaly", "given": "Alexander", "initials": "A"}, {"family": "Schmiedel", "given": "Stefan", "initials": "S"}, {"family": "Seilmaier", "given": "Michael", "initials": "M"}, {"family": "Rumpf", "given": "Benedikt", "initials": "B"}, {"family": "Banasik", "given": "Miroslaw", "initials": "M"}, {"family": "Krajewska", "given": "Magdalena", "initials": "M"}, {"family": "Catanese", "given": "Lorenzo", "initials": "L"}, {"family": "Rupprecht", "given": "Harald", "initials": "H"}, {"family": "Czerwienska", "given": "Beata", "initials": "B"}, {"family": "Peters", "given": "Bjoern", "initials": "B"}, {"family": "Nilsson", "given": "Asa", "initials": "A"}, {"family": "Rothfuss", "given": "Katja", "initials": "K"}, {"family": "Luebbert", "given": "Christoph", "initials": "C"}, {"family": "Mischak", "given": "Harald", "initials": "H"}, {"family": "Beige", "given": "Joachim", "initials": "J"}], "type": "posted-content", "published": "2022-01-23", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.01.20.22269599", "pmid": null, "labels": {"Category: Health": null, "Type: Preprint": null, "Category: Biochemistry": null, "Category: Omicron VoC": null}, "xrefs": [], "notes": [], "created": "2022-01-24T10:43:58.258Z", "modified": "2022-01-26T16:37:04.903Z"}, {"entity": "publication", "iuid": "d9acb2305e904b518161562e376043a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d9acb2305e904b518161562e376043a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d9acb2305e904b518161562e376043a1"}}, "title": "Pilot application of Lecture-Panel-Discussion Model (LPDM) in global collaborative neurosurgical education: a novel training paradigm innovated by the Swedish African Neurosurgery Collaboration.", "authors": [{"family": "Uche", "given": "Enoch Ogbonnaya", "initials": "EO"}, {"family": "Sundblom", "given": "Jimmy", "initials": "J"}, {"family": "Iloabachie", "given": "Izuchukwu", "initials": "I"}, {"family": "Ozoh", "given": "Ignatius I", "initials": "II"}, {"family": "Alalade", "given": "Andrew", "initials": "A"}, {"family": "Revesz", "given": "David", "initials": "D"}, {"family": "Sandvik", "given": "Ulrika", "initials": "U"}, {"family": "Olsson", "given": "Martin", "initials": "M"}, {"family": "Mezue", "given": "Wilfred C", "initials": "WC"}, {"family": "Tisell", "given": "Magnus", "initials": "M"}, {"family": "Ryttlefors", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2022-01-21", "journal": {"title": "Acta Neurochir (Wien)", "issn": "0942-0940", "issn-l": "0001-6268"}, "abstract": "Disruptions in global surgery educational routines by the COVID-19 pandemic have elicited demands for alternative formats for rendering qualitative neurosurgical education. This study presents application of a novel model of online neurosurgical course, the Lecture-Panel-Discussion Model (LPDM).\n\nThis is a cross-sectional survey of participants who attended the Swedish African Neurosurgery Collaboration (SANC)-100A course. Participants evaluated the course through an online self-administered questionnaire using a 5-point Likert scale ranging from very poor-1, poor-2, average (fair)-3, good-4, to excellent-5. SANC-100A comprises a tripod of Lectures, Panel review, and interactive case Discussion. This model (LPDM) was innovated by SANC and applied at the Enugu International Neurosurgery course in February 2021.\n\nThere were 71 attendees, 19 were course faculty, while 52 were participants. Thirty-five attended from Nigeria, 11 from Sweden, 3 from Malawi, 2 from Senegal, and 1 from the UK. Among 44 participants who completed the questionnaire, there were 9 fellows and 35 residents. The overall median course Likert rating was 4.65 \u00b1 0.1. The median overall rating for course events was similar between day 1 (Likert score = 4.45) and day 2 (Likert score = 4.55), U = 55, Z score = 1.10, P = 0.27. The median rating for lectures was 4.50 \u00b1 0.2 and varied from 4.40 on day 1 to 4.55 on day 2. The median rating for panel review was 4.60 \u00b1 0.1 and varied from 4.55 on day 1 to 4.65 on day 2. Interactive case discussions were rated 4.80 on both course days. There was a significant variability in the rating profiles of the course tripod: U = 24.5, P = 0.03. Fifty-one (98%) participants believe LPDM was COVID-19-compliant, while 90% believe the course was beneficial to training and practice.\n\nInitial application of LPDM is rewarded with both high acceptance and high rating among participants.", "doi": "10.1007/s00701-021-05071-z", "pmid": "35059854", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00701-021-05071-z"}], "notes": [], "created": "2022-01-26T10:20:45.277Z", "modified": "2022-01-26T10:20:45.291Z"}, {"entity": "publication", "iuid": "92f14a1b80b249c09fd7efedcc332a40", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/92f14a1b80b249c09fd7efedcc332a40.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/92f14a1b80b249c09fd7efedcc332a40"}}, "title": "Participatory research in times of COVID-19 and beyond: Adjusting your methodological toolkits.", "authors": [{"family": "Sattler", "given": "Claudia", "initials": "C"}, {"family": "Rommel", "given": "Jens", "initials": "J"}, {"family": "Chen", "given": "Cheng", "initials": "C"}, {"family": "Garc\u00eda-Llorente", "given": "Marina", "initials": "M"}, {"family": "Guti\u00e9rrez-Brice\u00f1o", "given": "In\u00e9s", "initials": "I"}, {"family": "Prager", "given": "Katrin", "initials": "K"}, {"family": "Reyes", "given": "Maria F", "initials": "MF"}, {"family": "Schr\u00f6ter", "given": "Barbara", "initials": "B"}, {"family": "Schulze", "given": "Christoph", "initials": "C"}, {"family": "van Bussel", "given": "Lenny G J", "initials": "LGJ"}, {"family": "Loft", "given": "Lasse", "initials": "L"}, {"family": "Matzdorf", "given": "Bettina", "initials": "B"}, {"family": "Kelemen", "given": "Eszter", "initials": "E"}], "type": "journal article", "published": "2022-01-21", "journal": {"title": "One Earth", "issn": "2590-3322", "volume": "5", "issue": "1", "pages": "62-73", "issn-l": null}, "abstract": "Solving grand environmental societal challenges calls for transdisciplinary and participatory methods in social-ecological research. These methods enable co-designing the research, co-producing the results, and co-creating the impacts together with concerned stakeholders. COVID-19 has had serious impacts on the choice of research methods, but reflections on recent experiences of \"moving online\" are still rare. In this perspective, we focus on the challenge of adjusting different participatory methods to online formats used in five transdisciplinary social-ecological research projects. The key added value of our research is the lessons learned from a comparison of the pros and cons of adjusting a broader set of methods to online formats. We conclude that combining the adjusted online approaches with well-established face-to-face formats into more inclusive hybrid approaches can enrich and diversify the pool of available methods for postpandemic research. Furthermore, a more diverse group of participants can be engaged in the research process.", "doi": "10.1016/j.oneear.2021.12.006", "pmid": "35098107", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2590-3322(21)00724-7"}, {"db": "pmc", "key": "PMC8779601"}], "notes": [], "created": "2022-02-06T16:55:58.322Z", "modified": "2022-02-06T16:55:58.360Z"}, {"entity": "publication", "iuid": "8e0d6a9eb1764446be31099616f108c4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e0d6a9eb1764446be31099616f108c4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e0d6a9eb1764446be31099616f108c4"}}, "title": "T cell immune responses following vaccination with mRNA BNT162b2 against SARS-CoV-2 in patients with chronic lymphocytic leukemia: results from a prospective open-label clinical trial.", "authors": [{"family": "Blixt", "given": "Lisa", "initials": "L"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Lundin", "given": "Jeanette", "initials": "J"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Lange", "given": "Joshua", "initials": "J"}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2022-01-20", "journal": {"title": "Haematologica", "issn": "1592-8721", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Not available.", "doi": "10.3324/haematol.2021.280300", "pmid": "35045694", "labels": {"Category: Health": null, "Research Area: Vaccine": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null, "Category: Biochemistry": null, "Funder: VR": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-27T07:06:13.587Z", "modified": "2022-02-08T19:16:56.522Z"}, {"entity": "publication", "iuid": "3d77564dec9844b2be0cb5f748485ca0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3d77564dec9844b2be0cb5f748485ca0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3d77564dec9844b2be0cb5f748485ca0"}}, "title": "SARS-CoV-2 infections in children: Understanding diverse outcomes.", "authors": [{"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}], "type": "journal article", "published": "2022-01-20", "journal": {"title": "Immunity", "issn": "1074-7613", "issn-l": null}, "abstract": "SARS-CoV-2 infections mostly lead to mild or even asymptomatic infections in children, but the reasons for this are not fully understood. More efficient local tissue responses, better thymic function, and cross-reactive immunity have all been proposed to explain this. In rare cases of children and young people, but very rarely in adults, post-infectious hyperinflammatory syndromes can develop and be serious. Here, I will discuss our current understanding of SARS-CoV-2 infections in children and hypothesize that a life history and energy allocation perspective might offer an additional explanation to mild infections, viral dynamics, and the higher incidence of rare multisystem inflammatory syndromes in children and young people.", "doi": "10.1016/j.immuni.2022.01.014", "pmid": "35093190", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1074-7613(22)00043-7"}, {"db": "pmc", "key": "PMC8769938"}], "notes": [], "created": "2022-01-24T09:19:30.621Z", "modified": "2022-02-06T17:06:42.917Z"}, {"entity": "publication", "iuid": "e83da5ea90ee4b06bc174c3608e8d23b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e83da5ea90ee4b06bc174c3608e8d23b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e83da5ea90ee4b06bc174c3608e8d23b"}}, "title": "Novel universal SARS-CoV DNA vaccine inducing neutralizing antibodies to huCoV-19/WH01, Beta, Delta and Omicron variants and T cells to Bat-CoV", "authors": [{"family": "Appelberg", "given": "K Sofia", "initials": "KS"}, {"family": "Ahlen", "given": "Gustaf", "initials": "G"}, {"family": "Nikoyan", "given": "Negin", "initials": "N"}, {"family": "Yan", "given": "Jingy", "initials": "J"}, {"family": "Weber", "given": "Sofie", "initials": "S"}, {"family": "Larsson", "given": "Olivia", "initials": "O"}, {"family": "H\u00f6glund", "given": "Urban", "initials": "U"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Weber", "given": "Friedemann", "initials": "F", "orcid": "0000-0001-9737-337X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cfac6ca689c5467396ede57ba57092da.json"}}, {"family": "Perlhamre", "given": "Emma", "initials": "E"}, {"family": "Apro", "given": "Johanna", "initials": "J"}, {"family": "Gidlund", "given": "Eva Karin", "initials": "EK"}, {"family": "Tuvesson", "given": "Ola", "initials": "O"}, {"family": "Cadossi", "given": "Matteo", "initials": "M"}, {"family": "Salati", "given": "SImona", "initials": "S"}, {"family": "Tegel", "given": "Hanna", "initials": "H"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Frelin", "given": "Lars", "initials": "L", "orcid": "0000-0001-7452-1667", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd26ddedec244820a9a1e19f76cc5cf8.json"}}, {"family": "mirazimi", "given": "ali", "initials": "a"}, {"family": "Sallberg", "given": "Matti", "initials": "M", "orcid": "0000-0002-8858-5132", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ef589af054b4f94a635ce4021d19ed6.json"}}], "type": "posted-content", "published": "2022-01-20", "journal": {"title": "Research Square", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.21203/rs.3.rs-1276351/v1", "pmid": null, "labels": {"Category: Health": null, "Category: Omicron VoC": null, "Type: Preprint": null, "Category: Drug Discovery": null, "Category: Vaccines": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2022-01-24T10:55:49.379Z", "modified": "2022-01-26T16:38:06.958Z"}, {"entity": "publication", "iuid": "f302bc3bc1c24074ab1bb8f78b8b243f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f302bc3bc1c24074ab1bb8f78b8b243f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f302bc3bc1c24074ab1bb8f78b8b243f"}}, "title": "High prevalence of olfactory disorders 18 months after contracting COVID-19", "authors": [{"family": "Tognetti", "given": "Arnaud", "initials": "A"}, {"family": "Thunell", "given": "Evelina", "initials": "E"}, {"family": "Olsson", "given": "Mats J", "initials": "MJ"}, {"family": "Greilert", "given": "Nina", "initials": "N"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Lundstr\u00f6m", "given": "Johan N", "initials": "JN", "orcid": "0000-0002-3529-8981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a92f50aea024a1fbf0cfda979efef11.json"}}], "type": "posted-content", "published": "2022-01-20", "journal": {"title": "MedRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.01.20.22269490", "pmid": null, "labels": {"Category: Health": null, "Type: Preprint": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [], "notes": [], "created": "2022-01-24T10:45:16.438Z", "modified": "2022-02-09T10:21:37.412Z"}, {"entity": "publication", "iuid": "2d906d15a3034d36b0d9c471c35ad573", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d906d15a3034d36b0d9c471c35ad573.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d906d15a3034d36b0d9c471c35ad573"}}, "title": "A Workflow of Integrated Resources to Catalyze Network Pharmacology Driven COVID-19 Research.", "authors": [{"family": "Zahor\u00e1nszky-K\u0151halmi", "given": "Gergely", "initials": "G", "orcid": "0000-0002-2534-8770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70698b6bf86944b29f19bbf9c2d86ee0.json"}}, {"family": "Siramshetty", "given": "Vishal B", "initials": "VB"}, {"family": "Kumar", "given": "Praveen", "initials": "P"}, {"family": "Gurumurthy", "given": "Manideep", "initials": "M"}, {"family": "Grillo", "given": "Busola", "initials": "B"}, {"family": "Mathew", "given": "Biju", "initials": "B"}, {"family": "Metaxatos", "given": "Dimitrios", "initials": "D"}, {"family": "Backus", "given": "Mark", "initials": "M"}, {"family": "Mierzwa", "given": "Tim", "initials": "T"}, {"family": "Simon", "given": "Reid", "initials": "R"}, {"family": "Grishagin", "given": "Ivan", "initials": "I"}, {"family": "Brovold", "given": "Laura", "initials": "L"}, {"family": "Math\u00e9", "given": "Ewy A", "initials": "EA", "orcid": "0000-0003-4491-8107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/526c8532f9b844e1b26ff8f4b131aab2.json"}}, {"family": "Hall", "given": "Matthew D", "initials": "MD", "orcid": "0000-0002-5073-442X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5b2d73bea15483db987059eccaf46ad.json"}}, {"family": "Michael", "given": "Samuel G", "initials": "SG"}, {"family": "Godfrey", "given": "Alexander G", "initials": "AG"}, {"family": "Mestres", "given": "Jordi", "initials": "J", "orcid": "0000-0002-5202-4501", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ca82613f43dc465b847d30b08de7c560.json"}}, {"family": "Jensen", "given": "Lars J", "initials": "LJ", "orcid": "0000-0001-7885-715X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0da9399aac04409eb3b87ac9f00728a8.json"}}, {"family": "Oprea", "given": "Tudor I", "initials": "TI", "orcid": "0000-0002-6195-6976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c480e6e946bd4c43ac430fd0309df71e.json"}}], "type": "journal article", "published": "2022-01-20", "journal": {"title": "J Chem Inf Model", "issn": "1549-960X", "issn-l": null}, "abstract": "In the event of an outbreak due to an emerging pathogen, time is of the essence to contain or to mitigate the spread of the disease. Drug repositioning is one of the strategies that has the potential to deliver therapeutics relatively quickly. The SARS-CoV-2 pandemic has shown that integrating critical data resources to drive drug-repositioning studies, involving host-host, host-pathogen, and drug-target interactions, remains a time-consuming effort that translates to a delay in the development and delivery of a life-saving therapy. Here, we describe a workflow we designed for a semiautomated integration of rapidly emerging data sets that can be generally adopted in a broad network pharmacology research setting. The workflow was used to construct a COVID-19 focused multimodal network that integrates 487 host-pathogen, 63 278 host-host protein, and 1221 drug-target interactions. The resultant Neo4j graph database named \"Neo4COVID19\" is made publicly accessible via a web interface and via API calls based on the Bolt protocol. Details for accessing the database are provided on a landing page (https://neo4covid19.ncats.io/). We believe that our Neo4COVID19 database will be a valuable asset to the research community and will catalyze the discovery of therapeutics to fight COVID-19.", "doi": "10.1021/acs.jcim.1c00431", "pmid": "35057621", "labels": {"Category: Health": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-26T10:21:09.747Z", "modified": "2022-01-26T10:21:09.983Z"}, {"entity": "publication", "iuid": "8fb2b02dc0744b3997713ef4b0ec145e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8fb2b02dc0744b3997713ef4b0ec145e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8fb2b02dc0744b3997713ef4b0ec145e"}}, "title": "A Method for Estimating the Number of Infections From the Reported Number of Deaths.", "authors": [{"family": "Br\u00e4nnstr\u00f6m", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Sj\u00f6din", "given": "Henrik", "initials": "H"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}], "type": "journal article", "published": "2022-01-20", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "648545", "issn-l": "2296-2565"}, "abstract": "At the outset of an epidemic, available case data typically underestimate the total number of infections due to insufficient testing, potentially hampering public responses. Here, we present a method for statistically estimating the true number of cases with confidence intervals from the reported number of deaths and estimates of the infection fatality ratio; assuming that the time from infection to death follows a known distribution. While the method is applicable to any epidemic with a significant mortality rate, we exemplify the method by applying it to COVID-19. Our findings indicate that the number of unreported COVID-19 infections in March 2020 was likely to be at least one order of magnitude higher than the reported cases, with the degree of underestimation among the countries considered being particularly high in the United Kingdom.", "doi": "10.3389/fpubh.2021.648545", "pmid": "35111706", "labels": {"Category: Other": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8802715"}], "notes": [], "created": "2022-02-06T16:48:45.724Z", "modified": "2022-02-06T16:48:45.737Z"}, {"entity": "publication", "iuid": "f1d335e823fa47ffaf043b0138ee7479", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1d335e823fa47ffaf043b0138ee7479.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1d335e823fa47ffaf043b0138ee7479"}}, "title": "Overexpression of the SARS-CoV-2 receptor angiotensin converting enzyme 2 in cardiomyocytes of failing hearts.", "authors": [{"family": "Vukusic", "given": "Kristina", "initials": "K"}, {"family": "Thorsell", "given": "Annika", "initials": "A"}, {"family": "Muslimovic", "given": "Aida", "initials": "A"}, {"family": "Jonsson", "given": "Marianne", "initials": "M"}, {"family": "Dellgren", "given": "G\u00f6ran", "initials": "G"}, {"family": "Lindahl", "given": "Anders", "initials": "A"}, {"family": "Sandstedt", "given": "Joakim", "initials": "J"}, {"family": "Hammarsten", "given": "Ola", "initials": "O"}], "type": "journal article", "published": "2022-01-19", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "12", "issue": "1", "pages": "965", "issn-l": "2045-2322"}, "abstract": "Hospitalized patients who die from Covid-19 often have pre-existing heart disease. The SARS-CoV-2 virus is dependent on the ACE2 receptor to be able to infect cells. It is possible that the strong link between cardiovascular comorbidities and a poor outcome following a SARS-CoV-2 infection is sometimes due to viral myocarditis. The aim was to examine the expression of ACE2 in normal hearts and hearts from patients with terminal heart failure. The ACE2 expression was measured by global quantitative proteomics and RT-qPCR in left ventricular (LV) tissue from explanted hearts. Immunohistochemistry was used to examine ACE2 expression in cardiomyocytes, fibroblasts and endothelial cells. In total, tissue from 14 organ donors and 11 patients with terminal heart failure were included. ACE2 expression was 2.6 times higher in 4 hearts from patients with terminal heart failure compared with 6 healthy donor hearts. The results were confirmed by immunohistochemistry where more than half of cardiomyocytes or fibroblasts showed expression of ACE2 in hearts from patients with terminal heart failure. In healthy donor hearts ACE2 was not expressed or found in few fibroblasts. A small subpopulation of endothelial cells expressed ACE2 in both groups. Upregulated ACE2 expression in cardiomyocytes may increase the risk of SARS-CoV-2 myocarditis in patients with heart failure.", "doi": "10.1038/s41598-022-04956-y", "pmid": "35046458", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-022-04956-y"}, {"db": "pmc", "key": "PMC8770525"}], "notes": [], "created": "2022-01-27T07:04:03.703Z", "modified": "2022-01-27T07:04:03.717Z"}, {"entity": "publication", "iuid": "6635e3f8535740968c9fdc520dc224e6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6635e3f8535740968c9fdc520dc224e6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6635e3f8535740968c9fdc520dc224e6"}}, "title": "Loss of Y in leukocytes as a risk factor for critical COVID-19 in men", "authors": [{"family": "Bruhn-Olszewska", "given": "Bo\u017cena", "initials": "B", "orcid": "0000-0003-2141-0247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dedfa26bf2d048b7b8e45b5e057c92a1.json"}}, {"family": "Davies", "given": "Hanna", "initials": "H", "orcid": "0000-0002-6289-3815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e47c749e23324a6dbbe27c4fc980d44d.json"}}, {"family": "Sarkisyan", "given": "Daniil", "initials": "D", "orcid": "0000-0002-2451-4386", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e35e9da7e5074089a9c12af2f8fac728.json"}}, {"family": "Juhas", "given": "Ulana", "initials": "U", "orcid": "0000-0001-8393-5845", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2eb6588951114e6ea94c2044e057baa8.json"}}, {"family": "Rychlicka-Buniowska", "given": "Edyta", "initials": "E", "orcid": "0000-0001-8050-2489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/408d42c146da46dcb096476de68870ce.json"}}, {"family": "W\u00f3jcik", "given": "Magdalena", "initials": "M"}, {"family": "Horbacz", "given": "Monika", "initials": "M", "orcid": "0000-0003-1644-2957", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cd269c5ae484ab5bdf9cc96b4e5803d.json"}}, {"family": "J\u0105kalski", "given": "Marcin", "initials": "M", "orcid": "0000-0002-5481-9148", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65510c2de4984c5ab5c221af3c00258e.json"}}, {"family": "Olszewski", "given": "Pawe\u0142", "initials": "P", "orcid": "0000-0002-2788-5254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7546c2273a0b41318e03b0b6b8386644.json"}}, {"family": "Westholm", "given": "Jakub O", "initials": "JO", "orcid": "0000-0002-6849-6220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8f7f8b02a9748f09626d373504ed84d.json"}}, {"family": "Smialowska", "given": "Agata", "initials": "A"}, {"family": "Wierzba", "given": "Karol", "initials": "K", "orcid": "0000-0003-1257-4047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/acaa0094bb054d10bf5b9037e5e05468.json"}}, {"family": "Naluai", "given": "\u00c5sa Torinsson", "initials": "\u00c5T", "orcid": "0000-0002-0504-6492", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ec904138d45463ea133b3ea7a062e08.json"}}, {"family": "Jern", "given": "Niklas", "initials": "N"}, {"family": "Andersson", "given": "Lars Magnus", "initials": "LM", "orcid": "0000-0002-9203-5969", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9cc0ebc0e6d433fbec6ca555a329ca3.json"}}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD", "orcid": "0000-0002-7075-1059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4c50079915c44d39c996741c6156bfa.json"}}, {"family": "Filipowicz", "given": "Natalia", "initials": "N", "orcid": "0000-0002-9673-2649", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf3f9e58fdfe466e8e4a224c0b451878.json"}}, {"family": "Janson", "given": "Eva Tiensuu", "initials": "ET", "orcid": "0000-0002-1649-4880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce68e15ca80a4813b20e055ea8c408c0.json"}}, {"family": "Rubertsson", "given": "Sten", "initials": "S"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Dumanski", "given": "Jan P", "initials": "JP", "orcid": "0000-0002-1489-1452", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f429f169193e41c78e76c206e9540cd8.json"}}], "type": "posted-content", "published": "2022-01-19", "journal": {"title": "MedRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.01.19.22269521", "pmid": null, "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Type: Preprint": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Funder: VR": null, "Research Area: Call 2": null}, "xrefs": [], "notes": [], "created": "2022-01-24T10:47:41.713Z", "modified": "2022-11-22T05:53:59.725Z"}, {"entity": "publication", "iuid": "1048b06d2e1146f2a460ad4b0a260684", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1048b06d2e1146f2a460ad4b0a260684.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1048b06d2e1146f2a460ad4b0a260684"}}, "title": "Assessment of biosafety implementation in clinical diagnostic laboratories in pakistan related to the COVID-19 pandemic.", "authors": [{"family": "Sarwar", "given": "Samreen", "initials": "S"}, {"family": "Shahzad", "given": "Faheem", "initials": "F"}, {"family": "Vajeeha", "given": "Ayesha", "initials": "A"}, {"family": "Munir", "given": "Rimsha", "initials": "R"}, {"family": "Yaqoob", "given": "Amina", "initials": "A"}, {"family": "Naeem", "given": "Aniqa", "initials": "A"}, {"family": "Sattar", "given": "Mamoona", "initials": "M"}, {"family": "Gull", "given": "Sheereen", "initials": "S"}], "type": "journal article", "published": "2022-01-19", "journal": {"title": "J Biosaf Biosecur", "issn": "2588-9338", "issn-l": null}, "abstract": "Laboratory diagnostic capacity is crucial for an optimal national response to a public health emergency such as the COVID-19 pandemic. Preventing laboratory-acquired infections and the loss of critical human resources, especially during a public health emergency, requires laboratories to have a good biorisk management system in place. In this study, we aimed to evaluate laboratory biosafety and biosecurity in Pakistan during the COVID-19 pandemic. In this cross-sectional study, a self-rated anonymous questionnaire was distributed to laboratory professionals (LPs) working in clinical diagnostic laboratories, including laboratories performing polymerase chain reaction (PCR)-based COVID-19 diagnostic testing in Punjab, Sindh, Khyber Pakhtunkhwa, and Gilgit-Baltistan provinces as well as Islamabad during March 2020 to April 2020. The questionnaire assessed knowledge and perceptions of LPs, resource availability, and commitment by top management in these laboratories. In total, 58.6% of LPs performing COVID-19 testing reported that their laboratory did not conduct a biorisk assessment before starting COVID-19 testing in their facility. Only 31% of LPs were aware that COVID-19 testing could be performed at a biosafety level 2 laboratory, as per the World Health Organization interim biosafety guidelines. A sufficiently high percentage of LPs did not feel confident in their ability to handle COVID-19 samples (32.8%), spills (43.1%), or other accidents (32.8%). These findings demonstrate the need for effective biosafety program implementation, proper training, and establishing competency assessment methods. These findings also suggested that identifying and addressing gaps in existing biorisk management systems through sustainable interventions and preparing LPs for surge capacity is crucial to better address public health emergencies.", "doi": "10.1016/j.jobb.2022.01.001", "pmid": "35072000", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2588-9338(22)00001-2"}, {"db": "pmc", "key": "PMC8768056"}], "notes": [], "created": "2022-01-26T10:16:06.535Z", "modified": "2022-01-26T10:16:06.564Z"}, {"entity": "publication", "iuid": "ac9452c851ea4129b2d9be95df87dfe5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac9452c851ea4129b2d9be95df87dfe5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac9452c851ea4129b2d9be95df87dfe5"}}, "title": "The global pandemic and changes in women's reproductive health: an observational study.", "authors": [{"family": "Haile", "given": "Liya", "initials": "L", "orcid": "0000-0001-9170-4879", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a55e8c5467f64375a0bb34018bcb3253.json"}}, {"family": "van de Roemer", "given": "Niels", "initials": "N"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K", "orcid": "0000-0001-6516-1444", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be16fea6bd1042048b8a4008dc005014.json"}}, {"family": "Perell\u00f3 Cap\u00f3", "given": "Josep", "initials": "J"}, {"family": "Lete Lasa", "given": "I\u00f1aki", "initials": "I", "orcid": "0000-0002-0266-3970", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c04f7883288f46889b29558128ed0ed6.json"}}, {"family": "Vannuccini", "given": "Silvia", "initials": "S", "orcid": "0000-0001-5790-587X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a60b6384996455eaf747bba3f2f5be0.json"}}, {"family": "Koch", "given": "Martin C", "initials": "MC"}, {"family": "Hildebrandt", "given": "Thomas", "initials": "T", "orcid": "0000-0002-7605-4465", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1f934af7558459d8e228980d1423995.json"}}, {"family": "Calaf", "given": "Joaquim", "initials": "J", "orcid": "0000-0002-2407-7884", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3750306e7cd4f69a59a3120e08c051d.json"}}], "type": "journal article", "published": "2022-01-18", "journal": {"title": "Eur J Contracept Reprod Health Care", "issn": "1473-0782", "pages": "1-5", "issn-l": null}, "abstract": "The COVID-19 global pandemic has led to the death of millions around the world and impacted the overall health of many people. In this article we aim to compare reproductive health indicators in the first 6 months of 2020 to the prior year, as well as explore stress and quality of life during this time.\n\nThis retrospective observational study examined the menstrual cycles of 1159 women who were using a fertility tracking device to record their menstrual cycle and BBT data. We utilised a supplemental mobile application to administer a supplemental survey to collect data on stress and quality of life. Descriptive analyses were conducted with t-tests for two-group comparisons.\n\nStudy participants from 15 countries contributed to a total of 13,194 cycles. 23.1% (268/1159) responded to the survey focussed on assessing psychosocial distress. 44.4% (119/268) of the study participants reported that they had noticed a change in their menstrual cycle, temperature curve, or menstruation in the past 12 months. Cycle analysis found the average cycle length and pre-ovulation phase length was longer in the first 6 months of 2019, while the average days of menstruation was slightly longer in 2020.\n\nOur findings indicate that menstrual cycle indicators changed only slightly in the first 6 months of 2020 but were still statistically significant. We were also able to understand that these study participants had some level of awareness of changes to their menstrual health.", "doi": "10.1080/13625187.2021.2024161", "pmid": "35040737", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-27T07:10:09.391Z", "modified": "2022-01-27T07:35:46.040Z"}, {"entity": "publication", "iuid": "87391f11a89f41ccbdefccfb22773983", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87391f11a89f41ccbdefccfb22773983.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87391f11a89f41ccbdefccfb22773983"}}, "title": "Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function.", "authors": [{"family": "Martin", "given": "Darren P", "initials": "DP"}, {"family": "Lytras", "given": "Spyros", "initials": "S"}, {"family": "Lucaci", "given": "Alexander G", "initials": "AG"}, {"family": "Maier", "given": "Wolfgang", "initials": "W"}, {"family": "Gr\u00fcning", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Shank", "given": "Stephen D", "initials": "SD"}, {"family": "Weaver", "given": "Steven", "initials": "S"}, {"family": "MacLean", "given": "Oscar A", "initials": "OA"}, {"family": "Orton", "given": "Richard J", "initials": "RJ"}, {"family": "Lemey", "given": "Philippe", "initials": "P"}, {"family": "Boni", "given": "Maciej F", "initials": "MF"}, {"family": "Tegally", "given": "Houriiyah", "initials": "H"}, {"family": "Harkins", "given": "Gordon", "initials": "G"}, {"family": "Scheepers", "given": "Cathrine", "initials": "C"}, {"family": "Bhiman", "given": "Jinal N", "initials": "JN"}, {"family": "Everatt", "given": "Josie", "initials": "J"}, {"family": "Amoako", "given": "Daniel G", "initials": "DG"}, {"family": "San", "given": "James Emmanuel", "initials": "JE"}, {"family": "Giandhari", "given": "Jennifer", "initials": "J"}, {"family": "Sigal", "given": "Alex", "initials": "A"}, {"family": "NGS-SA", "given": "", "initials": ""}, {"family": "Williamson", "given": "Carolyn", "initials": "C"}, {"family": "Hsiao", "given": "Nei-Yuan", "initials": "NY"}, {"family": "von Gottberg", "given": "Anne", "initials": "A"}, {"family": "De Klerk", "given": "Arne", "initials": "A"}, {"family": "Shafer", "given": "Robert W", "initials": "RW"}, {"family": "Robertson", "given": "David L", "initials": "DL"}, {"family": "Wilkinson", "given": "Robert J", "initials": "RJ"}, {"family": "Sewell", "given": "B Trevor", "initials": "BT"}, {"family": "Lessells", "given": "Richard", "initials": "R"}, {"family": "Nekrutenko", "given": "Anton", "initials": "A"}, {"family": "Greaney", "given": "Allison J", "initials": "AJ"}, {"family": "Starr", "given": "Tyler N", "initials": "TN"}, {"family": "Bloom", "given": "Jesse D", "initials": "JD"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Wilkinson", "given": "Eduan", "initials": "E"}, {"family": "Gupta", "given": "Ravindra K", "initials": "RK"}, {"family": "de Oliveira", "given": "Tulio", "initials": "T"}, {"family": "Kosakovsky Pond", "given": "Sergei L", "initials": "SL"}], "type": "preprint", "published": "2022-01-18", "journal": {"title": "bioRxiv", "issn-l": null}, "abstract": "Among the 30 non-synonymous nucleotide substitutions in the Omicron S-gene are 13 that have only rarely been seen in other SARS-CoV-2 sequences. These mutations cluster within three functionally important regions of the S-gene at sites that will likely impact (i) interactions between subunits of the Spike trimer and the predisposition of subunits to shift from down to up configurations, (ii) interactions of Spike with ACE2 receptors, and (iii) the priming of Spike for membrane fusion. We show here that, based on both the rarity of these 13 mutations in intrapatient sequencing reads and patterns of selection at the codon sites where the mutations occur in SARS-CoV-2 and related sarbecoviruses, prior to the emergence of Omicron the mutations would have been predicted to decrease the fitness of any genomes within which they occurred. We further propose that the mutations in each of the three clusters therefore cooperatively interact to both mitigate their individual fitness costs, and adaptively alter the function of Spike. Given the evident epidemic growth advantages of Omicron over all previously known SARS-CoV-2 lineages, it is crucial to determine both how such complex and highly adaptive mutation constellations were assembled within the Omicron S-gene, and why, despite unprecedented global genomic surveillance efforts, the early stages of this assembly process went completely undetected.", "doi": "10.1101/2022.01.14.476382", "pmid": "35075456", "labels": {"Category: Omicron VoC": null, "Type: Preprint": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8786225"}], "notes": [], "created": "2022-02-23T11:16:48.684Z", "modified": "2022-02-23T11:17:06.235Z"}, {"entity": "publication", "iuid": "9b93133c2f8a45d1927cf1886ac94805", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b93133c2f8a45d1927cf1886ac94805.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b93133c2f8a45d1927cf1886ac94805"}}, "title": "Potential role of neurofilament in COVID-19 and preeclampsia.", "authors": [{"family": "Samara", "given": "Athina", "initials": "A"}, {"family": "Herlenius", "given": "Eric", "initials": "E"}, {"family": "O' Brien", "given": "Patrick", "initials": "P"}, {"family": "Khalil", "given": "Asma", "initials": "A"}], "type": "news", "published": "2022-01-18", "journal": {"title": "Cell Rep Med", "issn": "2666-3791", "volume": "3", "issue": "1", "pages": "100490", "issn-l": "2666-3791"}, "abstract": "Neurofilament light (NFL) is a promising circulating biomarker in preeclampsia and COVID-19, even without evident neurological complications. Several pathways might contribute to the elevated serum NFL levels seen in both pathologies. Future studies will determine whether NFL is a long COVID marker and delineate NFL's role in COVID-19-associated preeclampsia.", "doi": "10.1016/j.xcrm.2021.100490", "pmid": "35103255", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2666-3791(21)00367-0"}, {"db": "pmc", "key": "PMC8764750"}], "notes": [], "created": "2022-02-06T16:51:21.210Z", "modified": "2022-02-06T16:51:21.225Z"}, {"entity": "publication", "iuid": "e409259f8b5c49bca0bd43c1a5e47f07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e409259f8b5c49bca0bd43c1a5e47f07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e409259f8b5c49bca0bd43c1a5e47f07"}}, "title": "Politicians polarize and experts depolarize public support for COVID-19 management policies across countries.", "authors": [{"family": "Flores", "given": "Alexandra", "initials": "A"}, {"family": "Cole", "given": "Jennifer C", "initials": "JC"}, {"family": "Dickert", "given": "Stephan", "initials": "S"}, {"family": "Eom", "given": "Kimin", "initials": "K"}, {"family": "Jiga-Boy", "given": "Gabriela M", "initials": "GM", "orcid": "0000-0003-3163-8798", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dac90441cd3642eabb3ed61932ba22db.json"}}, {"family": "Kogut", "given": "Tehila", "initials": "T", "orcid": "0000-0001-8652-5112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56c2ee61d26b45c799115f41b68d6c77.json"}}, {"family": "Loria", "given": "Riley", "initials": "R"}, {"family": "Mayorga", "given": "Marcus", "initials": "M", "orcid": "0000-0001-5471-0655", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d12c67fe7be433282cdecf395edca4a.json"}}, {"family": "Pedersen", "given": "Eric J", "initials": "EJ"}, {"family": "Pereira", "given": "Beatriz", "initials": "B", "orcid": "0000-0002-1091-0943", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b713e52b7d4744f2bd2de606a92dae2f.json"}}, {"family": "Rubaltelli", "given": "Enrico", "initials": "E", "orcid": "0000-0002-7521-755X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2283c6a303c24124a700b154b2d62b97.json"}}, {"family": "Sherman", "given": "David K", "initials": "DK"}, {"family": "Slovic", "given": "Paul", "initials": "P", "orcid": "0000-0002-7473-6403", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e42d731725348998fcff156270435f5.json"}}, {"family": "V\u00e4stfj\u00e4ll", "given": "Daniel", "initials": "D"}, {"family": "Van Boven", "given": "Leaf", "initials": "L", "orcid": "0000-0003-4187-8779", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd5678aef638457dab8264e41775c3dc.json"}}], "type": "journal article", "published": "2022-01-18", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "119", "issue": "3", "issn-l": "0027-8424"}, "abstract": "Political polarization impeded public support for policies to reduce the spread of COVID-19, much as polarization hinders responses to other contemporary challenges. Unlike previous theory and research that focused on the United States, the present research examined the effects of political elite cues and affective polarization on support for policies to manage the COVID-19 pandemic in seven countries (n = 12,955): Brazil, Israel, Italy, South Korea, Sweden, the United Kingdom, and the United States. Across countries, cues from political elites polarized public attitudes toward COVID-19 policies. Liberal and conservative respondents supported policies proposed by ingroup politicians and parties more than the same policies from outgroup politicians and parties. Respondents disliked, distrusted, and felt cold toward outgroup political elites, whereas they liked, trusted, and felt warm toward both ingroup political elites and nonpartisan experts. This affective polarization was correlated with policy support. These findings imply that policies from bipartisan coalitions and nonpartisan experts would be less polarizing, enjoying broader public support. Indeed, across countries, policies from bipartisan coalitions and experts were more widely supported. A follow-up experiment replicated these findings among US respondents considering international vaccine distribution policies. The polarizing effects of partisan elites and affective polarization emerged across nations that vary in cultures, ideologies, and political systems. Contrary to some propositions, the United States was not exceptionally polarized. Rather, these results suggest that polarizing processes emerged simply from categorizing people into political ingroups and outgroups. Political elites drive polarization globally, but nonpartisan experts can help resolve the conflicts that arise from it.", "doi": "10.1073/pnas.2117543119", "pmid": "35042779", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2117543119"}], "notes": [], "created": "2022-01-27T07:06:55.025Z", "modified": "2022-01-27T07:06:55.297Z"}, {"entity": "publication", "iuid": "be6c92969d4f4a0eb3c57bee4076a14e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be6c92969d4f4a0eb3c57bee4076a14e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be6c92969d4f4a0eb3c57bee4076a14e"}}, "title": "Impact of the COVID-19 pandemic on the incidence and mortality of hospital-onset bloodstream infection: a cohort study.", "authors": [{"family": "Valik", "given": "John Karlsson", "initials": "JK", "orcid": "0000-0002-4521-1886", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eac431272ad4d8eb13c8d56ddef182c.json"}}, {"family": "Hedberg", "given": "Pontus", "initials": "P"}, {"family": "Holmberg", "given": "Fredrik", "initials": "F"}, {"family": "van der Werff", "given": "Suzanne Desir\u00e9e", "initials": "SD"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2022-01-18", "journal": {"title": "BMJ Qual Saf", "issn": "2044-5423", "issn-l": null}, "abstract": "The COVID-19 pandemic burdens hospitals, but consequences for quality of care outcomes such as healthcare-associated infections are largely unknown. This cohort included all adult hospital episodes (n=186 945) at an academic centre between January 2018 and January 2021. Data were collected from the hospitals' electronic health record data repository. Hospital-onset bloodstream infection (HOB) was defined as any positive blood culture obtained \u226548 hours after admission classified based on microbiological and hospital administrative data. Subgroup analyses were performed with exclusion of potential contaminant bacteria. The cohort was divided into three groups: controls (prepandemic period), non-COVID-19 (pandemic period) and COVID-19 (pandemic period) based on either PCR-confirmed SARS-CoV-2 infections from respiratory samples or International Classification of Diseases 10th Revision diagnoses U071 and U72 at discharge. Adjusted incidence rate ratios (aIRR) and risk of death in patients with HOB were compared between the prepandemic and pandemic periods using Poisson and logistic regression. The incidence of HOB was increased for the COVID-19 group compared with the prepandemic period (aIRR 3.34, 95% CI 2.97 to 3.75). In the non-COVID-19 group, the incidence was slightly increased compared with prepandemic levels (aIRR 1.20, 95% CI 1.08 to 1.32), but the difference decreased when excluding potential contaminant bacteria (aIRR 1.15, 95% CI 1.00 to 1.31, p=0.04). The risk of dying increased for both the COVID-19 group (adjusted odds ratio (aOR) 2.44, 95% CI 1.75 to 3.38) and the non-COVID-19 group (aOR 1.63, 95% CI 1.22 to 2.16) compared with the prepandemic controls. These findings were consistent also when excluding potential contaminants. In summary, we observed a higher incidence of HOB during the COVID-19 pandemic, and the mortality risk associated with HOB was greater, compared with the prepandemic period. Results call for specific attention to quality of care during the pandemic.", "doi": "10.1136/bmjqs-2021-014243", "pmid": "35042764", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjqs-2021-014243"}], "notes": [], "created": "2022-01-27T07:07:10.389Z", "modified": "2022-01-27T07:07:10.470Z"}, {"entity": "publication", "iuid": "782143d0f4d244e4864d0676fde7793d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/782143d0f4d244e4864d0676fde7793d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/782143d0f4d244e4864d0676fde7793d"}}, "title": "How has the University Community Been Coping During the COVID-19 Pandemic? An Iranian Survey.", "authors": [{"family": "Ahmadi", "given": "Fereshteh", "initials": "F"}, {"family": "Cetrez", "given": "\u00d6nver A", "initials": "\u00d6A"}, {"family": "Akhavan", "given": "Sharareh", "initials": "S"}, {"family": "Khodayarifard", "given": "Mohammad", "initials": "M"}, {"family": "Zandi", "given": "Saeid", "initials": "S"}], "type": "journal article", "published": "2022-01-18", "journal": {"title": "Front Sociol", "issn": "2297-7775", "issn-l": null, "volume": "6", "issue": null, "pages": "645670"}, "abstract": "Objectives: The present study, one of the first to look at COVID-19 and coping in Iran, aimed at mapping, describing and understanding the coping methods academics employ as protective resources to deal with the psychological challenges and social isolation during the COVID-19 pandemic. We specifically aimed at identifying the meaning-making coping methods used and understanding the influence of culture. The guiding research question has been: Are there differences in meaning-making coping methods by gender, age group, work/student status, and place of residence? Design: The study, which used convenience sampling, was a quantitative inquiry. It employed a modified version of the RCOPE scale among faculty/staff members and students in Iran (n = 196, 75% women). Results: The most frequently used coping method among all subgroups of the study sample was thinking that life is part of a greater whole, followed by praying to Allah/God. The least used coping methods were the negative religious ones. Gender differences were found for being alone and contemplating, stronger for men. Thinking that life is part of a greater whole was found mainly among on-campus students. Praying to Allah/God was most common among the youngest staff and students, as well as among women. Two segments of respondents were discovered-the Theists and Non-theists-where the former used more religious coping methods, were more likely to be women, older staff and students, on-campus students, married, have children, and lived in capital. Conclusions: Our conclusion is that the RCOPE methods, which include religious and spiritual meaning-making methods, are of great importance to the studied Iranian informants. However, they use some secular existential meaning-making coping strategies too. This is explained by the role of religion in the larger orientation system and frame of reference in parallel with a secular worldview. Further, a sharp distinction between religious and secular worldviews was not found, which is explained by the fact that secular norms are hardly internalized in ways of thinking in Iran.", "doi": "10.3389/fsoc.2021.645670", "pmid": "35118154", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "645670"}, {"db": "pmc", "key": "PMC8804233"}], "notes": [], "created": "2022-02-06T16:46:47.401Z", "modified": "2022-11-22T05:40:56.916Z"}, {"entity": "publication", "iuid": "8e579aec7c4344b894b2a8a236a106ba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e579aec7c4344b894b2a8a236a106ba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e579aec7c4344b894b2a8a236a106ba"}}, "title": "Can They Stay or Will They Go? A Cross Sectional Study of Managers' Attitudes towards Their Senior Employees.", "authors": [{"family": "Nilsson", "given": "Kerstin", "initials": "K", "orcid": "0000-0002-3193-205X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81335f480e0d4c7590701b5a164c269e.json"}}, {"family": "Nilsson", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2022-01-18", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "3", "issn-l": null}, "abstract": "A larger amount of older people need to participate in working life due to the global demographic change. It is the employer, through the manager, who enables employees to have access to measures in the workplace that facilitate and enable a sustainable extended working life. The aim of this study was to evaluate work life factors associated with managers believing their employees can work versus wanting to work until age 65 or older. This cross-sectional study included 249 managers in the Swedish municipality sector. Logistic regression analysis was used to investigate associations between different univariate estimates and in data modelling using the SwAge-model. The result stated that 79% of managers believed their employees 'can' work and 58% of managers believed their employees 'want to' work until age 65 or older. Health, physical work environment, skills and competence are associated the strongest to managers believing employees 'can' work until age 65 or older. Insufficient social support at work and lacking possibilities for relocations associated the strongest to managers believing employees would not 'want to' work until age 65 or older. Though, several countries (especially in Europe) have included in their social policy measures that retirement age be increased after 65, proposing ages approaching 70. When these proposals become laws, through obligation, people will have no choice (if they want to or if they can continue working). However, people's attitudes to work may be different (especially after the COVID-19 pandemic), and this analysis of the participating managers' attitudes showed there is a difference between why employees 'can' versus 'want' to work respectively. Therefore, different strategies may be needed to contribute to employees both being able to and willing to participate in working life until an older age. These findings on managers' perspectives, regarding whether they believe employees would be able to versus would want to work and the SwAge-model, will hopefully contribute to an increased understanding of organisational actions and measures in the process of creating a sustainable extended working life and to increase senior employees' employability.", "doi": "10.3390/ijerph19031057", "pmid": "35162080", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph19031057"}], "notes": [], "created": "2022-02-17T06:10:01.874Z", "modified": "2022-02-17T06:10:15.286Z"}, {"entity": "publication", "iuid": "90a1865683244d27a10a4f43f5f9bd8d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90a1865683244d27a10a4f43f5f9bd8d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90a1865683244d27a10a4f43f5f9bd8d"}}, "title": "COVID-19 Severity and Cardiovascular Disease: An Inseparable Link.", "authors": [{"family": "Henein", "given": "Michael Y", "initials": "MY", "orcid": "0000-0002-6089-5614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe79bb10eb4348948599443b7b396faf.json"}}, {"family": "Cameli", "given": "Matteo", "initials": "M", "orcid": "0000-0003-3872-8964", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e64899d051a84cd8a0cac5f503e03251.json"}}, {"family": "Pastore", "given": "Maria Concetta", "initials": "MC", "orcid": "0000-0002-7223-141X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/55e79d1bf0294864ae1cdb57aa4a4844.json"}}, {"family": "Mandoli", "given": "Giulia Elena", "initials": "GE", "orcid": "0000-0002-3184-3006", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc927b7843b44bdd87232563c7faff19.json"}}], "type": "editorial", "published": "2022-01-18", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "11", "issue": "3", "issn-l": "2077-0383"}, "abstract": "The COVID-19 pandemic is a global health issue that has so far affected over 250 million people worldwide [...].", "doi": "10.3390/jcm11030479", "pmid": "35159931", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "jcm11030479"}], "notes": [], "created": "2022-02-17T06:11:18.116Z", "modified": "2022-02-17T06:11:32.211Z"}, {"entity": "publication", "iuid": "6cff8b952d0f4794bf399b05db141eb3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6cff8b952d0f4794bf399b05db141eb3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6cff8b952d0f4794bf399b05db141eb3"}}, "title": "Perceived Changes in Sexual Interest and Distress About Discrepant Sexual Interest During the First Phase of COVID-19 Pandemic: A Multi-Country Assessment in Cohabiting Partnered Individuals.", "authors": [{"family": "\u0160tulhofer", "given": "Aleksandar", "initials": "A", "orcid": "0000-0001-5138-3644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1eaa60cb1a874757ab9306915557c39c.json"}}, {"family": "Mehuli\u0107", "given": "Jasmina", "initials": "J"}, {"family": "Briken", "given": "Peer", "initials": "P"}, {"family": "Klapilov\u00e1", "given": "Kate\u0159ina", "initials": "K"}, {"family": "de Graaf", "given": "Hanneke", "initials": "H"}, {"family": "Carvalheira", "given": "Ana Alexandra", "initials": "AA"}, {"family": "L\u00f6fgren-M\u00e5rtenson", "given": "Charlotta", "initials": "C"}, {"family": "Nobre", "given": "Pedro", "initials": "P"}, {"family": "Chollier", "given": "Marie", "initials": "M"}, {"family": "K\u00f6se", "given": "\u00d6zlem", "initials": "\u00d6"}, {"family": "Elmerstig", "given": "Eva", "initials": "E"}, {"family": "Lan\u00e7on", "given": "Christophe", "initials": "C"}, {"family": "Pl\u00e1\u0161ilov\u00e1", "given": "Leona", "initials": "L"}, {"family": "Schr\u00f6der", "given": "Johanna", "initials": "J"}], "type": "journal article", "published": "2022-01-17", "journal": {"title": "Arch Sex Behav", "issn": "1573-2800", "issn-l": "0004-0002"}, "abstract": "Due to COVID-19 pandemic, different restrictive measures in terms of physical distancing and lockdowns have been introduced in most European countries, affecting all facets of social life. Currently, little is known about how partnered individuals perceive changes in their sexual life during this complex emergency. This study explored retrospectively assessed changes in sexual interest for one's partner and levels of distress related to perceived sexual interest discrepancy during the first phase of the pandemic in a large-scale online sample of partnered individuals (n = 4813; Mage = 38.5 years, SD = 10.74) recruited between May and July 2020 in seven European Union countries and Turkey. We also examined the possible role of approach/avoidance motives for sex in reported changes in sexual interest and associated distress. Most participants (53%) reported no change in their sexual interest during the pandemic, followed by those who reported an increase (28.5%). The pattern was similar across the eight countries. Distress about discrepant sexual interest, which was only weakly related to changes in sexual interest, was significantly associated with relationship quality and emotional closeness with a partner, coping with and worrying about the pandemic, and specific motivation for sex. In contrast to avoidant and relationship-focused approach motivation, ego-focused approach motivation was related to stable sexual interest during the pandemic. The current study contributes to the understanding of the link between sexual interest and complex emergencies. Considering that the COVID-19 pandemic continues, the reported experiences and perceptions are prone to change.", "doi": "10.1007/s10508-021-02279-z", "pmid": "35039982", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10508-021-02279-z"}, {"db": "pmc", "key": "PMC8763301"}], "notes": [], "created": "2022-01-27T07:36:01.051Z", "modified": "2022-01-27T07:36:01.110Z"}, {"entity": "publication", "iuid": "65f8bc7f05004142a11717a6c44b2815", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65f8bc7f05004142a11717a6c44b2815.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65f8bc7f05004142a11717a6c44b2815"}}, "title": "Multiomics integration-based molecular characterizations of COVID-19.", "authors": [{"family": "Li", "given": "Chuan-Xing", "initials": "CX", "orcid": "0000-0003-2189-5010", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b85683a869f446be80700b375582d4d3.json"}}, {"family": "Gao", "given": "Jing", "initials": "J", "orcid": "0000-0002-7732-456X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ec4995699874336b6f0eca4f9812fd5.json"}}, {"family": "Zhang", "given": "Zicheng", "initials": "Z"}, {"family": "Chen", "given": "Lu", "initials": "L"}, {"family": "Li", "given": "Xun", "initials": "X"}, {"family": "Zhou", "given": "Meng", "initials": "M"}, {"family": "Wheelock", "given": "\u00c5sa M", "initials": "\u00c5M"}], "type": "journal article", "published": "2022-01-17", "journal": {"title": "Brief Bioinform", "issn": "1477-4054", "volume": "23", "issue": "1", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rapidly became a global health challenge, leading to unprecedented social and economic consequences. The mechanisms behind the pathogenesis of SARS-CoV-2 are both unique and complex. Omics-scale studies are emerging rapidly and offer a tremendous potential to unravel the puzzle of SARS-CoV-2 pathobiology, as well as moving forward with diagnostics, potential drug targets, risk stratification, therapeutic responses, vaccine development and therapeutic innovation. This review summarizes various aspects of understanding multiomics integration-based molecular characterizations of COVID-19, which to date include the integration of transcriptomics, proteomics, genomics, lipidomics, immunomics and metabolomics to explore virus targets and developing suitable therapeutic solutions through systems biology tools. Furthermore, this review also covers an abridgment of omics investigations related to disease pathogenesis and virulence, the role of host genetic variation and a broad array of immune and inflammatory phenotypes contributing to understanding COVID-19 traits. Insights into this review, which combines existing strategies and multiomics integration profiling, may help further advance our knowledge of COVID-19.", "doi": "10.1093/bib/bbab485", "pmid": "34864875", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC8769889"}, {"db": "pii", "key": "6447675"}], "notes": [], "created": "2023-01-13T13:28:31.791Z", "modified": "2023-07-13T11:29:23.254Z"}, {"entity": "publication", "iuid": "92bd885f2293490888030e991224833d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/92bd885f2293490888030e991224833d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/92bd885f2293490888030e991224833d"}}, "title": "Healthcare use in 700 000 children and adolescents for six months after covid-19: before and after register based cohort study.", "authors": [{"family": "Magnusson", "given": "Karin", "initials": "K", "orcid": "0000-0003-4851-5794", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2fe6a28f36f40a998b8c9fc3c5ebe73.json"}}, {"family": "Skyrud", "given": "Katrine Damgaard", "initials": "KD"}, {"family": "Suren", "given": "P\u00e5l", "initials": "P"}, {"family": "Greve-Isdahl", "given": "Margrethe", "initials": "M"}, {"family": "St\u00f8rdal", "given": "Ketil", "initials": "K"}, {"family": "Kristoffersen", "given": "Doris Tove", "initials": "DT"}, {"family": "Telle", "given": "Kjetil", "initials": "K"}], "type": "journal article", "published": "2022-01-17", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "376", "pages": "e066809", "issn-l": null}, "abstract": "To explore whether and for how long use of healthcare services is increased among children and adolescents after covid-19.\n\nBefore and after register based study.\n\nGeneral population of Norway.\n\nNorwegians aged 1-19 years (n=706 885) who were tested for SARS-CoV-2 from 1 August 2020 to 1 February 2021 (n=10 279 positive, n=275 859 negative) or not tested (n=420 747) and were not admitted to hospital, by age groups 1-5, 6-15, and 16-19 years.\n\nMonthly percentages of all cause and cause specific healthcare use in primary care (general practitioner, emergency ward) and specialist care (outpatient, inpatient) from six months before to about six months after the week of being tested for SARS-CoV-2, using a difference-in-differences approach.\n\nA substantial short term relative increase in primary care use was observed for participants during the first month after a positive SARS-CoV-2 test result compared with those who tested negative (age 1-5 years: 339%, 95% confidence interval 308% to 369%; 6-15 years: 471%, 450% to 491%; 16-19 years: 401%, 380% to 422%). Use of primary care for the younger age groups was still increased at two months (1-5 years: 22%, 4% to 40%; 6-15 years: 14%, 2% to 26%) and three months (1-5 years: 26%, 7% to 46%, 6-15 years: 15%, 3% to 28%), but not for the oldest group (16-19 years: 11%, -2% to 24% and 6%, -7% to 19%, respectively). Children aged 1-5 years who tested positive also showed a minor long term (\u22646 months) relative increase in primary care use (13%, -0% to 26%) that was not observed for the older age groups, compared with same aged children who tested negative. Results were similar yet the age differences less pronounced compared with untested controls. For all age groups, the increase in primary care visits was due to respiratory and general or unspecified conditions. No increased use of specialist care was observed.\n\nCovid-19 among children and adolescents was found to have limited impact on healthcare services in Norway. Preschool aged children might take longer to recover (3-6 months) than primary or secondary school students (1-3 months), usually because of respiratory conditions.", "doi": "10.1136/bmj-2021-066809", "pmid": "35039315", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8762452"}], "notes": [], "created": "2022-01-27T07:38:14.686Z", "modified": "2022-01-27T07:38:14.743Z"}, {"entity": "publication", "iuid": "7dd32d0115a74a9aa9d819dcd6f91cf8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7dd32d0115a74a9aa9d819dcd6f91cf8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7dd32d0115a74a9aa9d819dcd6f91cf8"}}, "title": "Severe multisystem inflammatory syndrome (MIS-C/A) after confirmed SARS-CoV-2 infection: a report of four adult cases", "authors": [{"family": "Sansone", "given": "M", "initials": "M"}, {"family": "Studahl", "given": "M", "initials": "M"}, {"family": "Berg", "given": "S", "initials": "S"}, {"family": "Gissl\u00e9n", "given": "M", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}, {"family": "Sundell", "given": "N", "initials": "N"}], "type": "journal-article", "published": "2022-01-16", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4235", "issn-l": null, "volume": null, "issue": null, "pages": "1-6"}, "abstract": "Multisystem inflammatory syndrome (MIS) triggered by a recent SARS-Cov-2 infection has been recognised worldwide. Although predominantly affecting children (MIS-C), similar presentations have been reported among adults (MIS-A).\n\nA retrospective case series describing four critically ill patients with MIS-C/A diagnosed between January and April 2021 at Sahlgrenska University Hospital, Gothenburg, Sweden. Clinical presentation, laboratory and radiological findings, treatment and outcome are reported.\n\nCases occurred in previously healthy patients with a history of laboratory-confirmed mild SARS-CoV-2 infection four to seven weeks earlier. The median age was 24 years (range 19-43) and 3/4 were male. All fulfilled suggested MIS-C/A criteria according to the US Centre for Disease Control and all required care at an intensive care unit. Treatment was initiated with intravenous immunoglobulin, interleukin-1-receptor antagonists, and pulse steroids in 3/4 cases which resulted in rapid clinical improvement. No severe complications were noticed in any case during a three-month follow-up period.\n\nMIS-C/A should be considered, irrespective of age, in patients with fever, hyperinflammation and multiple organ system involvements emerging weeks after COVID-19. Previously suggested treatment regimens for MIS-C seem to be applicable also for MIS-A.", "doi": "10.1080/23744235.2021.2025422", "pmid": "35034549", "labels": {"Category: Health": null, "Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [], "notes": [], "created": "2022-01-27T07:41:24.997Z", "modified": "2022-02-06T17:32:32.457Z"}, {"entity": "publication", "iuid": "966230056df94b2e846d8626a6add138", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/966230056df94b2e846d8626a6add138.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/966230056df94b2e846d8626a6add138"}}, "title": "Long-term exposure to ambient air pollution and incidence of depression: A population-based cohort study in China.", "authors": [{"family": "Wei", "given": "Fang", "initials": "F"}, {"family": "Yu", "given": "Zhebin", "initials": "Z"}, {"family": "Zhang", "given": "Xinhan", "initials": "X"}, {"family": "Wu", "given": "Mengyin", "initials": "M"}, {"family": "Wang", "given": "Jianbing", "initials": "J"}, {"family": "Shui", "given": "Liming", "initials": "L"}, {"family": "Lin", "given": "Hongbo", "initials": "H"}, {"family": "Jin", "given": "Mingjuan", "initials": "M"}, {"family": "Tang", "given": "Mengling", "initials": "M"}, {"family": "Chen", "given": "Kun", "initials": "K"}], "type": "journal article", "published": "2022-01-15", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "volume": "804", "pages": "149986", "issn-l": "0048-9697"}, "abstract": "Long-term exposure to ambient air pollution was linked to depression incidence, although the results were limited and inconsistent.\n\nTo investigate the effects of long-term air pollution exposure on depression risk prospectively in China.\n\nThe present study used data from Yinzhou Cohort on adults without depression at baseline, and followed up until April 2020. Two-year moving average concentrations of particulate matter with a diameter \u2264 2.5 \u03bcm (PM2.5), \u226410 \u03bcm (PM10) and nitrogen dioxide (NO2) were measured using land-use regression (LUR) models for each participant. Depression cases were ascertained using the Health Information System (HIS) of the local health administration by linking the unique identifiers. We conducted Cox regression models with time-varying exposures to estimate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of depression with each pollutant, after adjusting for a sequence of individual covariates as demographic characteristics, lifestyles, and comorbidity. Besides, physical activity, baseline potential depressive symptoms, cancer status, COVID-19 pandemic, different outcome definitions and air pollution exposure windows were considered in sensitivity analyses.\n\nAmong the 30,712 adults with a mean age of 62.22 \u00b1 11.25, 1024 incident depression cases were identified over totaling 98,619 person-years of observation. Interquartile range increments of the air pollutants were associated with increased risks of depression, and the corresponding HRs were 1.59 (95%CI: 1.46, 1.72) for PM2.5, 1.49 (95%CI: 1.35, 1.64) for PM10 and 1.58 (95%CI: 1.42, 1.77) for NO2. Subgroup analyses suggested that participants without taking any protective measures towards air pollution were more susceptible. The results remained robust in all sensitivity analyses.\n\nLong-term exposure to ambient air pollution was identified as a risk factor for depression onset. Strategies to reduce air pollution are necessary to decrease the disease burden of depression.", "doi": "10.1016/j.scitotenv.2021.149986", "pmid": "34798713", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(21)05061-0"}], "notes": [], "created": "2021-11-26T14:04:59.512Z", "modified": "2021-11-26T14:04:59.526Z"}, {"entity": "publication", "iuid": "5eddcc6107ba40b295898a133c0168eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5eddcc6107ba40b295898a133c0168eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5eddcc6107ba40b295898a133c0168eb"}}, "title": "Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2.", "authors": [{"family": "Bahnan", "given": "Wael", "initials": "W"}, {"family": "Wrighton", "given": "Sebastian", "initials": "S"}, {"family": "Sundwall", "given": "Martin", "initials": "M"}, {"family": "Bl\u00e4ckberg", "given": "Anna", "initials": "A"}, {"family": "Larsson", "given": "Olivia", "initials": "O"}, {"family": "H\u00f6glund", "given": "Urban", "initials": "U"}, {"family": "Khakzad", "given": "Hamed", "initials": "H"}, {"family": "Godzwon", "given": "Magdalena", "initials": "M"}, {"family": "Walle", "given": "Maria", "initials": "M"}, {"family": "Elder", "given": "Elisabeth", "initials": "E"}, {"family": "Strand", "given": "Anna S\u00f6derlund", "initials": "AS"}, {"family": "Happonen", "given": "Lotta", "initials": "L"}, {"family": "Andr\u00e9", "given": "Oscar", "initials": "O"}, {"family": "Ahnlide", "given": "Johannes Kumra", "initials": "JK"}, {"family": "Hellmark", "given": "Thomas", "initials": "T"}, {"family": "Wendel-Hansen", "given": "Vidar", "initials": "V"}, {"family": "Wallin", "given": "Robert Pa", "initials": "RP"}, {"family": "Malmst\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Malmstr\u00f6m", "given": "Lars", "initials": "L"}, {"family": "Ohlin", "given": "Mats", "initials": "M"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}, {"family": "Nordenfelt", "given": "Pontus", "initials": "P"}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "12", "issue": null, "pages": "808932"}, "abstract": "Spike-specific antibodies are central to effective COVID19 immunity. Research efforts have focused on antibodies that neutralize the ACE2-Spike interaction but not on non-neutralizing antibodies. Antibody-dependent phagocytosis is an immune mechanism enhanced by opsonization, where typically, more bound antibodies trigger a stronger phagocyte response. Here, we show that Spike-specific antibodies, dependent on concentration, can either enhance or reduce Spike-bead phagocytosis by monocytes independently of the antibody neutralization potential. Surprisingly, we find that both convalescent patient plasma and patient-derived monoclonal antibodies lead to maximum opsonization already at low levels of bound antibodies and is reduced as antibody binding to Spike protein increases. Moreover, we show that this Spike-dependent modulation of opsonization correlate with the outcome in an experimental SARS-CoV-2 infection model. These results suggest that the levels of anti-Spike antibodies could influence monocyte-mediated immune functions and propose that non-neutralizing antibodies could confer protection to SARS-CoV-2 infection by mediating phagocytosis.", "doi": "10.3389/fimmu.2021.808932", "pmid": "35095897", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Category: Vaccines": null, "Research Area: Vaccine": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC8796240"}], "notes": [], "created": "2022-01-18T15:28:04.664Z", "modified": "2022-02-08T19:18:01.159Z"}, {"entity": "publication", "iuid": "0d6ac289da3a4cb4bb7423c49a0cf64a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d6ac289da3a4cb4bb7423c49a0cf64a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d6ac289da3a4cb4bb7423c49a0cf64a"}}, "title": "SARS-CoV-2 phase I transmission and mutability linked to the interplay of climatic variables: a global observation on the pandemic spread.", "authors": [{"family": "Sabarathinam", "given": "Chidambaram", "initials": "C"}, {"family": "Mohan Viswanathan", "given": "Prasanna", "initials": "P"}, {"family": "Senapathi", "given": "Venkatramanan", "initials": "V"}, {"family": "Karuppannan", "given": "Shankar", "initials": "S"}, {"family": "Samayamanthula", "given": "Dhanu Radha", "initials": "DR"}, {"family": "Gopalakrishnan", "given": "Gnanachandrasamy", "initials": "G"}, {"family": "Alagappan", "given": "Ramanathan", "initials": "R"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Environ Sci Pollut Res Int", "issn": "1614-7499", "issn-l": null}, "abstract": "The study aims to determine the impact of global meteorological parameters on SARS-COV-2, including population density and initiation of lockdown in twelve different countries. The daily trend of these parameters and COVID-19 variables from February 15th to April 25th, 2020, were considered. Asian countries show an increasing trend between infection rate and population density. A direct relationship between the time-lapse of the first infected case and the period of suspension of movement controls the transmissivity of COVID-19 in Asian countries. The increase in temperature has led to an increase in COVID-19 spread, while the decrease in humidity is consistent with the trend in daily deaths during the peak of the pandemic in European countries. Countries with 65\u00b0F temperature and 5 mm rainfall have a negative impact on COVID-19 spread. Lower oxygen availability in the atmosphere, fine droplets of submicron size together with infectious aerosols, and low wind speed have contributed to the increase in total cases and mortality in Germany and France. The onset of the D614G mutation and subsequent changes to D614 before March, later G614 in mid-March, and S943P, A831V, D839/Y/N/E in April were observed in Asian and European countries. The results of the correlation and factor analysis show that the COVID-19 cases and the climatic factors are significantly correlated with each other. The optimum meteorological conditions for the prevalence of G614 were identified. It was observed that the complex interaction of global meteorological factors and changes in the mutational form of CoV-2 phase I influenced the daily mortality rate along with other comorbid factors. The results of this study could help the public and policymakers to create awareness of the COVID-19 pandemic.", "doi": "10.1007/s11356-021-17481-8", "pmid": "35028838", "labels": {"Category: Genomics & transcriptomics": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11356-021-17481-8"}, {"db": "pmc", "key": "PMC8758228"}], "notes": [], "created": "2022-01-27T08:03:53.271Z", "modified": "2022-01-27T08:03:53.308Z"}, {"entity": "publication", "iuid": "26568a5562674a6aa0dba0ae047d4f41", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26568a5562674a6aa0dba0ae047d4f41.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26568a5562674a6aa0dba0ae047d4f41"}}, "title": "SARS-CoV-2 outbreaks in hospitals and long-term care facilities in Germany: a national observational study.", "authors": [{"family": "Suwono", "given": "Beneditta", "initials": "B"}, {"family": "Steffen", "given": "Annika", "initials": "A"}, {"family": "Schweickert", "given": "Birgitta", "initials": "B"}, {"family": "Sch\u00f6nfeld", "given": "Viktoria", "initials": "V"}, {"family": "Brandl", "given": "Michael", "initials": "M"}, {"family": "Sandfort", "given": "Mirco", "initials": "M"}, {"family": "Willrich", "given": "Niklas", "initials": "N"}, {"family": "Eckmanns", "given": "Tim", "initials": "T"}, {"family": "Haller", "given": "Sebastian", "initials": "S"}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "pages": "100303", "issn-l": null}, "abstract": "Outbreaks of coronavirus disease (COVID-19) in hospitals and long-term care facilities (LTCFs) pose serious public health threats. We analysed how frequency and size of SARS-CoV-2 outbreaks in hospitals and LTCFs have altered since the beginning of the pandemic, in particular since the start of the vaccination campaign.\n\nWe used mandatory notification data on SARS-CoV-2 cases in Germany and stratified by outbreak cases in hospitals and LTCFs. German vaccination coverage data were analysed. We studied the association of the occurrence of SARS-CoV-2 outbreaks and outbreak cases with SARS-CoV-2 cases in Germany throughout the four pandemic waves. We built also counterfactual scenarios with the first pandemic wave as the baseline.\n\nBy 21 September 2021, there were 4,147,387 SARS-CoV-2 notified cases since March 2020. About 20% of these cases were reported as being related to an outbreak, with 1% of the cases in hospitals and 4% in LTCFs. The median number of outbreak cases in the different phases was smaller (\u22645) in hospitals than in LTCFs (>10). In the first and second pandemic waves, we observed strong associations in both facility types between SARS-CoV-2 outbreak cases and total number of notified SARS-CoV-2 cases. However, during the third pandemic wave we observed a decline in outbreak cases in both facility types and only a weak association between outbreak cases and all cases.\n\nThe vaccination campaign and non-pharmaceutical interventions have been able to protect vulnerable risk groups in hospitals and LTCFs.\n\nNo specific funding.", "doi": "10.1016/j.lanepe.2021.100303", "pmid": "35043103", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00289-1"}, {"db": "pmc", "key": "PMC8759004"}], "notes": [], "created": "2022-01-27T07:06:39.744Z", "modified": "2022-01-27T07:06:39.757Z"}, {"entity": "publication", "iuid": "d5b05f520ab34ed8b3f72d7f97878f26", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5b05f520ab34ed8b3f72d7f97878f26.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5b05f520ab34ed8b3f72d7f97878f26"}}, "title": "Perceptions of changes in practice patterns and patient care among heart failure nurses during the COVID-19 pandemic.", "authors": [{"family": "Prasun", "given": "Marilyn A", "initials": "MA"}, {"family": "Blakeman", "given": "John R", "initials": "JR"}, {"family": "Vuckovic", "given": "Karen", "initials": "K"}, {"family": "Kim", "given": "MyoungJin", "initials": "M"}, {"family": "Albert", "given": "Nancy", "initials": "N"}, {"family": "Stamp", "given": "Kelly D", "initials": "KD"}, {"family": "Jaarsma", "given": "Tiny", "initials": "T"}, {"family": "Riegel", "given": "Barbara", "initials": "B"}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Heart Lung", "issn": "1527-3288", "volume": "52", "pages": "152-158", "issn-l": null}, "abstract": "The Coronavirus (COVID-19) had a profound impact on the delivery of care in both hospital and outpatient settings across the United States. Patients with heart failure (HF) and healthcare providers had to abruptly adapt.\n\nTo describe how the COVID-19 pandemic affected practice patterns of HF nurses.\n\nPracticing HF nurses completed a cross-sectional, anonymous, web-based survey of perceptions of HF practice. Analyses involved descriptive and comparative statistics.\n\nOf 171 nurses who completed surveys, outpatient HF visits decreased and 63.2% added telehealth visits. Despite spending about 29 min educating patients during visits, 27.5% of nurses perceived that the pandemic decreased patients' abilities to provide optimal self-care. Nurses reported decreased ability to collect objective data (62.4%; n = 78), although subjective assessment stayed the same (41.6%; n = 52).\n\nNurses' practice patterns provided insight into patient care changes made during COVID-19. Most core components of HF management were retained, but methods of delivery during the pandemic differed.", "doi": "10.1016/j.hrtlng.2022.01.004", "pmid": "35091263", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0147-9563(22)00005-X"}], "notes": [], "created": "2022-01-31T11:42:44.061Z", "modified": "2022-01-31T11:42:44.095Z"}, {"entity": "publication", "iuid": "35b02b7fb97748b09597e7d962742b69", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/35b02b7fb97748b09597e7d962742b69.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/35b02b7fb97748b09597e7d962742b69"}}, "title": "Patients' and clinicians' perspectives on the primary care consultations for acute respiratory infections during the first wave of the COVID-19 pandemic: an eight-country qualitative study in Europe.", "authors": [{"family": "Wanat", "given": "Marta", "initials": "M"}, {"family": "Hoste", "given": "Melanie Eugenie", "initials": "ME"}, {"family": "Gobat", "given": "Nina Helene", "initials": "NH"}, {"family": "Anastasaki", "given": "Marilena", "initials": "M"}, {"family": "B\u00f6hmer", "given": "Femke", "initials": "F"}, {"family": "Chlabicz", "given": "Slawomir", "initials": "S"}, {"family": "Colliers", "given": "Annelies", "initials": "A"}, {"family": "Farrell", "given": "Karen", "initials": "K"}, {"family": "Hollerbach", "given": "Sophie", "initials": "S"}, {"family": "Karkana", "given": "Maria-Nefeli", "initials": "MN"}, {"family": "Kinsman", "given": "John", "initials": "J"}, {"family": "Lionis", "given": "Christos", "initials": "C"}, {"family": "Marcinowicz", "given": "Ludmila", "initials": "L"}, {"family": "Reinhardt", "given": "Katrin", "initials": "K"}, {"family": "Skoglund", "given": "Ingmarie", "initials": "I"}, {"family": "Sundvall", "given": "P\u00e4r-Daniel", "initials": "PD"}, {"family": "Vellinga", "given": "Akke", "initials": "A"}, {"family": "Goossens", "given": "Herman", "initials": "H"}, {"family": "Butler", "given": "Christopher", "initials": "C"}, {"family": "van der Velden", "given": "Alike", "initials": "A"}, {"family": "Anthierens", "given": "Sibyl", "initials": "S"}, {"family": "Tonkin-Crine", "given": "Sarah", "initials": "S"}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "BJGP Open", "issn": "2398-3795", "issn-l": null}, "abstract": "The impact of the COVID-19 pandemic on patients' and clinicians' perceptions of healthcare-seeking behaviour and delivery of care is unclear. The pandemic accelerated the use of remote care and understanding its benefits and drawbacks may inform its implementation during this and future healthcare emergencies.\n\nTo explore patients' and primary care professionals' (PCPs) experiences of primary care delivery in the first wave of the pandemic.\n\nQualitative study using semi-structured interviews in primary care in eight European countries RESULTS: We conducted 146 interviews with 80 PCPs and 66 patients consulting for respiratory tract infection (RTI) symptoms, in eight European countries (England, Ireland, Belgium, the Netherlands, Greece, Poland, Sweden and Germany). Data was collected between April and July 2020 and analysed using thematic analysis. We found that patients accepted telemedicine when PCPs spent time to understand and address their concerns, but a minority preferred in-person consultations. PCPs felt that remote consultations created emotional distance between themselves and patients, and they reported having to manage diverse COVID-19-related medical and social concerns.\n\nRemote consultations for RTI symptoms may be acceptable long-term if both groups are happy to use this format but it is important that PCPs take time to address patients' concerns and provide safety-netting advice.", "doi": "10.3399/BJGPO.2021.0172", "pmid": "35031559", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "BJGPO.2021.0172"}], "notes": [], "created": "2022-01-27T08:02:44.413Z", "modified": "2022-01-27T08:02:44.450Z"}, {"entity": "publication", "iuid": "953bc095647240c7b0f72fe33901310d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/953bc095647240c7b0f72fe33901310d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/953bc095647240c7b0f72fe33901310d"}}, "title": "Mini review ATF4 and GRP78 as novel molecular targets in ER-Stress modulation for critical COVID-19 patients.", "authors": [{"family": "Shahriari-Felordi", "given": "Mahtab", "initials": "M"}, {"family": "Alikhani", "given": "Hani Keshavarz", "initials": "HK"}, {"family": "Hashemian", "given": "Seyed-Mohammad Reza", "initials": "SR"}, {"family": "Hassan", "given": "Moustapha", "initials": "M"}, {"family": "Vosough", "given": "Massoud", "initials": "M", "orcid": "0000-0001-5924-4366", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bf15c1fec524a79b8801694434587e3.json"}}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Mol Biol Rep", "issn": "1573-4978", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in more than 4.4 million deaths worldwide as of August 24, 2021. Viral infections such as SARS-CoV2 are associated with endoplasmic reticulum (ER) stress and also increased the level of reactive oxygen species. Activating transcription factor 4 (ATF4) is preferentially translated under integrated stress conditions and controls the genes involved in protein homeostasis, amino acid transport and metabolism, and also protection from oxidative stress. The GRP78, regulated either directly or indirectly by ATF4, is an essential chaperone in the ER and overexpressed and appears on the surface of almost all cells during stress and function as a SARS-CoV2 receptor. In this mini-review article, we briefly discuss the effects of SARS-CoV2 infection on the ER stress, and then the stress modulator functions of ATF4 and GRP78 as novel therapeutic targets were highlighted. Finally, the effects of GRP78 inhibitory components as potential factors for targeted therapies for COVID-19 critical cases were discussed.", "doi": "10.1007/s11033-021-07071-9", "pmid": "35028855", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11033-021-07071-9"}, {"db": "pmc", "key": "PMC8758217"}], "notes": [], "created": "2022-01-27T08:03:24.300Z", "modified": "2022-01-27T08:03:24.405Z"}, {"entity": "publication", "iuid": "804c55f24f01497f88d27d292dd8fda9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/804c55f24f01497f88d27d292dd8fda9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/804c55f24f01497f88d27d292dd8fda9"}}, "title": "Innovative vaccine approaches-a Keystone Symposia report.", "authors": [{"family": "Cable", "given": "Jennifer", "initials": "J"}, {"family": "Rappuoli", "given": "Rino", "initials": "R"}, {"family": "Klemm", "given": "Elizabeth J", "initials": "EJ"}, {"family": "Kang", "given": "Gagandeep", "initials": "G"}, {"family": "Mutreja", "given": "Ankur", "initials": "A"}, {"family": "Wright", "given": "Gavin J", "initials": "GJ"}, {"family": "Pizza", "given": "Mariagrazia", "initials": "M"}, {"family": "Castro", "given": "Sowmya Ajay", "initials": "SA"}, {"family": "Hoffmann", "given": "Joseph P", "initials": "JP"}, {"family": "Alter", "given": "Galit", "initials": "G"}, {"family": "Carfi", "given": "Andrea", "initials": "A"}, {"family": "Pollard", "given": "Andrew J", "initials": "AJ"}, {"family": "Krammer", "given": "Florian", "initials": "F"}, {"family": "Gupta", "given": "Ravindra K", "initials": "RK"}, {"family": "Wagner", "given": "Caroline E", "initials": "CE"}, {"family": "Machado", "given": "Viviane", "initials": "V"}, {"family": "Modjarrad", "given": "Kayvon", "initials": "K"}, {"family": "Corey", "given": "Lawrence", "initials": "L"}, {"family": "B Gilbert", "given": "Peter", "initials": "P"}, {"family": "Dougan", "given": "Gordon", "initials": "G"}, {"family": "Lurie", "given": "Nicole", "initials": "N"}, {"family": "Bjorkman", "given": "Pamela J", "initials": "PJ"}, {"family": "Chiu", "given": "Christopher", "initials": "C"}, {"family": "Nemes", "given": "Elisa", "initials": "E"}, {"family": "Gordon", "given": "Stephen B", "initials": "SB"}, {"family": "Steer", "given": "Andrew C", "initials": "AC"}, {"family": "Rudel", "given": "Thomas", "initials": "T"}, {"family": "Blish", "given": "Catherine A", "initials": "CA"}, {"family": "Sandberg", "given": "John Tyler", "initials": "JT"}, {"family": "Brennan", "given": "Kiva", "initials": "K"}, {"family": "Klugman", "given": "Keith P", "initials": "KP"}, {"family": "Stuart", "given": "Lynda M", "initials": "LM"}, {"family": "Madhi", "given": "Shabir A", "initials": "SA"}, {"family": "Karp", "given": "Christopher L", "initials": "CL"}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Ann N Y Acad Sci", "issn": "1749-6632", "issn-l": null}, "abstract": "The rapid development of COVID-19 vaccines was the result of decades of research to establish flexible vaccine platforms and understand pathogens with pandemic potential, as well as several novel changes to the vaccine discovery and development processes that partnered industry and governments. And while vaccines offer the potential to drastically improve global health, low-and-middle-income countries around the world often experience reduced access to vaccines and reduced vaccine efficacy. Addressing these issues will require novel vaccine approaches and platforms, deeper insight how vaccines mediate protection, and innovative trial designs and models. On June 28-30, 2021, experts in vaccine research, development, manufacturing, and deployment met virtually for the Keystone eSymposium \"Innovative Vaccine Approaches\" to discuss advances in vaccine research and development.", "doi": "10.1111/nyas.14739", "pmid": "35029310", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2022-01-27T08:03:06.543Z", "modified": "2022-01-27T08:03:06.584Z"}, {"entity": "publication", "iuid": "cd22576c59ec4b4a92e86277221098a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd22576c59ec4b4a92e86277221098a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd22576c59ec4b4a92e86277221098a9"}}, "title": "Exploring the Role of Innate Lymphocytes in the Immune System of Bats and Virus-Host Interactions.", "authors": [{"family": "Sia", "given": "Wan Rong", "initials": "WR"}, {"family": "Zheng", "given": "Yichao", "initials": "Y"}, {"family": "Han", "given": "Fei", "initials": "F"}, {"family": "Chen", "given": "Shiwei", "initials": "S"}, {"family": "Ma", "given": "Shaohua", "initials": "S"}, {"family": "Wang", "given": "Lin-Fa", "initials": "LF", "orcid": "0000-0003-2752-0535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f70fbadea6be4dc69282db33d7bfa8a5.json"}}, {"family": "Leeansyah", "given": "Edwin", "initials": "E", "orcid": "0000-0003-0505-4967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/440347079ebb4d979467290e00173eeb.json"}}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "14", "issue": "1", "issn-l": "1999-4915"}, "abstract": "Bats are reservoirs of a large number of viruses of global public health significance, including the ancestral virus for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the causative agent of coronavirus disease 2019 (COVID-19). Although bats are natural carriers of multiple pathogenic viruses, they rarely display signs of disease. Recent insights suggest that bats have a more balanced host defense and tolerance system to viral infections that may be linked to the evolutionary adaptation to powered flight. Therefore, a deeper understanding of bat immune system may provide intervention strategies to prevent zoonotic disease transmission and to identify new therapeutic targets. Similar to other eutherian mammals, bats have both innate and adaptive immune systems that have evolved to detect and respond to invading pathogens. Bridging these two systems are innate lymphocytes, which are highly abundant within circulation and barrier tissues. These cells share the characteristics of both innate and adaptive immune cells and are poised to mount rapid effector responses. They are ideally suited as the first line of defense against early stages of viral infections. Here, we will focus on the current knowledge of innate lymphocytes in bats, their function, and their potential role in host-pathogen interactions. Moreover, given that studies into bat immune systems are often hindered by a lack of bat-specific research tools, we will discuss strategies that may aid future research in bat immunity, including the potential use of organoid models to delineate the interplay between innate lymphocytes, bat viruses, and host tolerance.", "doi": "10.3390/v14010150", "pmid": "35062356", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "v14010150"}], "notes": [], "created": "2022-01-26T10:20:02.038Z", "modified": "2022-01-26T10:20:02.135Z"}, {"entity": "publication", "iuid": "5648e9ee898a42f18e107473e4e2c5cd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5648e9ee898a42f18e107473e4e2c5cd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5648e9ee898a42f18e107473e4e2c5cd"}}, "title": "Cyberchondria, Fear of COVID-19, and Risk Perception Mediate the Association between Problematic Social Media Use and Intention to Get a COVID-19 Vaccine.", "authors": [{"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK", "orcid": "0000-0003-0530-8138", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d442447b551649d8a5372c6bf0075c91.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Chen", "given": "Hsin-Pao", "initials": "HP"}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Timpka", "given": "Toomas", "initials": "T", "orcid": "0000-0001-6049-5402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebcb4fac20f845a4bd9eaa4bf1660ebb.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "1", "issn-l": null}, "abstract": "Vaccination is the most effective way to control the COVID-19 pandemic, but vaccination hesitancy threatens this effort worldwide. Consequently, there is a need to understand what influences individuals' intention to get a COVID-19 vaccine. Restriction of information gathering on societal developments to social media may influence attitudes towards COVID-19 vaccination through exposure to disinformation and imbalanced arguments. The present study examined the association between problematic social media use and intention to get the COVID-19 vaccine, taking into account the mediating roles of cyberchondria, fear of COVID-19, and COVID-19 risk perception. In a cross-sectional survey study, a total of 10,843 residents of Qazvin City, Iran completed measures on problematic social media use, fear of COVID-19, cyberchondria, COVID-19 risk perception, and intention to get a COVID-19 vaccine. The data were analyzed using structural equation modeling (SEM). The results showed that there was no direct association between problematic social media use and intention to get a COVID-19 vaccine. Nonetheless, cyberchondria, fear of COVID-19, and COVID-19 risk perception (each or serially) mediated associations between problematic social media use and intention to get a COVID-19 vaccine. These results add to the understanding of the role of problematic social media use in COVID-19 vaccine hesitancy, i.e., it is not the quantity of social media use per se that matters. This knowledge of the mediating roles of cyberchondria, fear of COVID-19, and COVID-19 risk perception can be used by public health experts and policymakers when planning educational interventions and other initiatives in COVID-19 vaccination programs.", "doi": "10.3390/vaccines10010122", "pmid": "35062783", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "vaccines10010122"}], "notes": [], "created": "2022-01-26T10:18:52.219Z", "modified": "2022-01-26T10:18:52.299Z"}, {"entity": "publication", "iuid": "359626a625b640da95854297479aa467", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/359626a625b640da95854297479aa467.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/359626a625b640da95854297479aa467"}}, "title": "Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19.", "authors": [{"family": "Huffman", "given": "Jennifer E", "initials": "JE", "orcid": "0000-0002-9672-2491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad45db8dbb6a4829ab92daae4d5d027f.json"}}, {"family": "Butler-Laporte", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-5388-0396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/529dc69151d3463e8480b975d70fa759.json"}}, {"family": "Khan", "given": "Atlas", "initials": "A", "orcid": "0000-0002-6651-2725", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1224033b68be41e285c2aba79a4e9b41.json"}}, {"family": "Pairo-Castineira", "given": "Erola", "initials": "E"}, {"family": "Drivas", "given": "Theodore G", "initials": "TG"}, {"family": "Peloso", "given": "Gina M", "initials": "GM", "orcid": "0000-0002-5355-8636", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0baa678d09b4574b98d26876010c8e4.json"}}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T", "orcid": "0000-0001-9510-5646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd273e50091d44c3b3e8d1473ce89b0a.json"}}, {"family": "COVID-19 Host Genetics Initiative", "given": "", "initials": ""}, {"family": "Ganna", "given": "Andrea", "initials": "A"}, {"family": "Verma", "given": "Anurag", "initials": "A"}, {"family": "Baillie", "given": "J Kenneth", "initials": "JK", "orcid": "0000-0001-5258-793X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35a72da3ac10479d87eba693bbe66b4d.json"}}, {"family": "Kiryluk", "given": "Krzysztof", "initials": "K"}, {"family": "Richards", "given": "J Brent", "initials": "JB", "orcid": "0000-0002-3746-9086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8994152547ee4765b1653b834c52a21a.json"}}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ee1510080704cf6a2a6972deb94123f.json"}}], "type": "journal article", "published": "2022-01-13", "journal": {"title": "Nat Genet", "issn": "1546-1718", "issn-l": null}, "abstract": "The OAS1/2/3 cluster has been identified as a risk locus for severe COVID-19 among individuals of European ancestry, with a protective haplotype of approximately 75 kilobases (kb) derived from Neanderthals in the chromosomal region 12q24.13. This haplotype contains a splice variant of OAS1, which occurs in people of African ancestry independently of gene flow from Neanderthals. Using trans-ancestry fine-mapping approaches in 20,779 hospitalized cases, we demonstrate that this splice variant is likely to be the SNP responsible for the association at this locus, thus strongly implicating OAS1 as an effector gene influencing COVID-19 severity.", "doi": "10.1038/s41588-021-00996-8", "pmid": "35027740", "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41588-021-00996-8"}, {"db": "URL", "key": "https://doi.org/10.5281/zenodo.5708333", "description": "https://doi.org/10.5281/zenodo.5708333"}, {"db": "URL", "key": "https://www.covid19hg.org/results/r6/", "description": "https://www.covid19hg.org/results/r6/"}, {"db": "URL", "key": "https://cadd.gs.washington.edu/score", "description": "https://cadd.gs.washington.edu/score"}, {"db": "URL", "key": "https://www.internationalgenome.org/data", "description": "https://www.internationalgenome.org/data"}], "notes": [], "created": "2022-01-16T12:57:33.433Z", "modified": "2022-01-16T13:00:04.033Z"}, {"entity": "publication", "iuid": "0800ea3269874a8fae8604415ed16e3e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0800ea3269874a8fae8604415ed16e3e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0800ea3269874a8fae8604415ed16e3e"}}, "title": "Integrated epi-econ assessment of vaccination.", "authors": [{"family": "Boppart", "given": "Timo", "initials": "T"}, {"family": "Harmenberg", "given": "Karl", "initials": "K"}, {"family": "Krusell", "given": "Per", "initials": "P"}, {"family": "Olsson", "given": "Jonna", "initials": "J"}], "type": "journal article", "published": "2022-01-13", "journal": {"title": "J Econ Dyn Control", "issn": "0165-1889", "pages": "104308", "issn-l": null}, "abstract": "Using an integrated epi-econ model, we compute the value of vaccines for Covid-19, both under a planner's solution and in competitive equilibrium. The specific model, developed in Boppart, Harmenberg, Hassler, Krusell, and Olsson (2021), factors in not just value-of-life aspects along with standard economic variables but also the value of leisure activities that rely on a social component. We find that the societal value of vaccination is large; we estimate that, translated into monetary terms, the value of vaccinating one young individual in the competitive equilibrium is $17,800. Externalities are large: less than half the societal value is internalized by individuals (assuming that they act purely in their self-interest). Finally, behavioral responses are important, with a substantial share of the value of vaccines being attributed to people enjoying more socially-oriented leisure when more people are vaccinated.", "doi": "10.1016/j.jedc.2022.104308", "pmid": "35039700", "labels": {"Category: Health": null, "Category: Vaccines": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0165-1889(22)00013-6"}, {"db": "pmc", "key": "PMC8755642"}], "notes": [], "created": "2022-01-27T07:36:18.097Z", "modified": "2022-01-27T07:37:59.857Z"}, {"entity": "publication", "iuid": "445906135b7d45e1bf7d39fe5cf4dffd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/445906135b7d45e1bf7d39fe5cf4dffd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/445906135b7d45e1bf7d39fe5cf4dffd"}}, "title": "Daily uplifts during the COVID-19 pandemic: what is considered helpful in everyday life?", "authors": [{"family": "Eklund", "given": "Rakel", "initials": "R"}, {"family": "Bondjers", "given": "Kristina", "initials": "K"}, {"family": "Hensler", "given": "Ida", "initials": "I"}, {"family": "Bragesj\u00f6", "given": "Maria", "initials": "M"}, {"family": "Johannesson", "given": "Kerstin Bergh", "initials": "KB"}, {"family": "Arnberg", "given": "Filip K", "initials": "FK"}, {"family": "Sveen", "given": "Josefin", "initials": "J"}], "type": "journal article", "published": "2022-01-13", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "85", "issn-l": null}, "abstract": "Knowledge of what is uplifting and helpful during pandemics could inform the design of sustainable pandemic recommendations in the future. We have explored individuals' views on helpful and uplifting aspects of everyday life during the coronavirus disease 2019 (COVID-19) pandemic.\n\nParticipants answered a brief, daily survey via text messages during 14 consecutive days in July-August, 2020. The survey included the question: \"During the past 24 hours, is there anything that has made you feel good or helped you in your life?\" We used content analysis to compile responses from 693 participants, who provided 4,490 free-text answers, which resulted in 24 categories subsumed under 7 themes.\n\nPositive aspects during the COVID-19 pandemic primarily related to social interactions, in real life or digitally, with family, friends and others. Other important aspects concerning work, colleagues and maintaining everyday life routines. One theme concerning vacations, going on excursions and being in nature. Leisure and recreation activities, such as hobbies and physical exercise, also emerged as important, as did health-related factors. Bodily sensations, thoughts, feelings and activities that benefited well-being were mentioned frequently. Lastly, people commented on the government strategies for containing COVID-19, and whether to comply with restrictions.\n\nTo summarize, daily uplifts and helpful aspects of everyday life centered around social relationships. To comply with recommendations on physical distancing, people found creative ways to maintain social connections both digitally and face-to-face. Social interaction, maintenance of everyday life routines, hobbies and physical activity appeared to be important for well-being.", "doi": "10.1186/s12889-022-12506-4", "pmid": "35027034", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-022-12506-4"}, {"db": "pmc", "key": "PMC8757393"}], "notes": [], "created": "2022-01-27T08:14:03.975Z", "modified": "2022-01-27T08:14:03.987Z"}, {"entity": "publication", "iuid": "9043e44a6cf04e9a8a14a5d652b177b5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9043e44a6cf04e9a8a14a5d652b177b5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9043e44a6cf04e9a8a14a5d652b177b5"}}, "title": "ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFN\u03b3-driven immunopathology.", "authors": [{"family": "Gawish", "given": "Riem", "initials": "R", "orcid": "0000-0003-4267-2131", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f738be3889746db9270e409da92b2b5.json"}}, {"family": "Starkl", "given": "Philipp", "initials": "P", "orcid": "0000-0001-7521-129X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8877b7b32fe4b20b9ef859ccaff5938.json"}}, {"family": "Pimenov", "given": "Lisabeth", "initials": "L"}, {"family": "Hladik", "given": "Anastasiya", "initials": "A"}, {"family": "Lakovits", "given": "Karin", "initials": "K"}, {"family": "Oberndorfer", "given": "Felicitas", "initials": "F"}, {"family": "Cronin", "given": "Shane Jf", "initials": "SJ"}, {"family": "Ohradanova-Repic", "given": "Anna", "initials": "A", "orcid": "0000-0002-8005-8522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05059e6a105642238652352cc49b5a8b.json"}}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G"}, {"family": "Agerer", "given": "Benedikt", "initials": "B"}, {"family": "Endler", "given": "Lukas", "initials": "L"}, {"family": "Capraz", "given": "T\u00fcmay", "initials": "T"}, {"family": "Perthold", "given": "Jan W", "initials": "JW"}, {"family": "Cikes", "given": "Domagoj", "initials": "D"}, {"family": "Koglgruber", "given": "Rubina", "initials": "R"}, {"family": "Hagelkruys", "given": "Astrid", "initials": "A"}, {"family": "Montserrat", "given": "Nuria", "initials": "N"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Boon", "given": "Louis", "initials": "L"}, {"family": "Stockinger", "given": "Hannes", "initials": "H", "orcid": "0000-0001-6404-4430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/134cb6399ed043879f4f834914429698.json"}}, {"family": "Bergthaler", "given": "Andreas", "initials": "A"}, {"family": "Oostenbrink", "given": "Chris", "initials": "C", "orcid": "0000-0002-4232-2556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37566a0341cf4fd38366e43218cffd23.json"}}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}, {"family": "Knapp", "given": "Sylvia", "initials": "S", "orcid": "0000-0001-9016-5244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81c1b98b50754c84b62f7867c9dc453f.json"}}], "type": "journal article", "published": "2022-01-13", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "11", "issn-l": null}, "abstract": "Despite tremendous progress in the understanding of COVID-19, mechanistic insight into immunological, disease-driving factors remains limited. We generated maVie16, a mouse-adapted SARS-CoV-2, by serial passaging of a human isolate. In silico modeling revealed how only three Spike mutations of maVie16 enhanced interaction with murine ACE2. maVie16 induced profound pathology in BALB/c and C57BL/6 mice, and the resulting mouse COVID-19 (mCOVID-19) replicated critical aspects of human disease, including early lymphopenia, pulmonary immune cell infiltration, pneumonia, and specific adaptive immunity. Inhibition of the proinflammatory cytokines IFN\u03b3 and TNF substantially reduced immunopathology. Importantly, genetic ACE2-deficiency completely prevented mCOVID-19 development. Finally, inhalation therapy with recombinant ACE2 fully protected mice from mCOVID-19, revealing a novel and efficient treatment. Thus, we here present maVie16 as a new tool to model COVID-19 for the discovery of new therapies and show that disease severity is determined by cytokine-driven immunopathology and critically dependent on ACE2 in vivo.", "doi": "10.7554/eLife.74623", "pmid": "35023830", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8776253"}, {"db": "pii", "key": "74623"}], "notes": [], "created": "2022-01-27T08:14:33.232Z", "modified": "2023-06-19T14:37:10.312Z"}, {"entity": "publication", "iuid": "d4dabb16e6ba4d8981a4d7c5fd8d170b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4dabb16e6ba4d8981a4d7c5fd8d170b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4dabb16e6ba4d8981a4d7c5fd8d170b"}}, "title": "SARS-CoV-2 induces a durable and antigen specific humoral immunity after asymptomatic to mild COVID-19 infection", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f28f2f6ac9648629c2d2de92fe7bb59.json"}}, {"family": "Jernbom Falk", "given": "August", "initials": "A", "orcid": "0000-0002-7773-1851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40d944d7fa964f4292f10012356a2730.json"}}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/305bca9e5c6c423898c272bf06ce2f2a.json"}}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Gabrielsson", "given": "Lena", "initials": "L"}, {"family": "Salomonsson", "given": "Ann Christin", "initials": "AC"}, {"family": "Isaksson", "given": "Eva", "initials": "E", "orcid": "0000-0003-0289-8750", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30fe14f786534ff49600d0ef859d30ca.json"}}, {"family": "Rudberg", "given": "Ann Sofie", "initials": "AS"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C", "orcid": "0000-0003-0880-5375", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7394cf1c96945888fc8765568f5407c.json"}}, {"family": "Andersson", "given": "Eni", "initials": "E", "orcid": "0000-0002-5115-0637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8200b399e954f3482aec53a62df3b54.json"}}, {"family": "Olofsson", "given": "Jennie", "initials": "J"}, {"family": "Skoglund", "given": "Lovisa", "initials": "L"}, {"family": "Yousef", "given": "Jamil", "initials": "J", "orcid": "0000-0001-5915-1258", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/324e111715fc4029badd136232057025.json"}}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f2dc27d02294a15a6f691be6aab641f.json"}}, {"family": "Olausson", "given": "Mikaela", "initials": "M"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Tegel", "given": "Hanna", "initials": "H"}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "journal-article", "published": "2022-01-12", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "17", "issue": "1", "pages": "e0262169"}, "abstract": null, "doi": "10.1371/journal.pone.0262169", "pmid": "35020778", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Research Area: Drug discovery and repurposing of drugs": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-01-05T09:43:17.149Z", "modified": "2022-02-14T14:46:43.789Z"}, {"entity": "publication", "iuid": "86bede1137574ee892bfd81d8edfb49c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86bede1137574ee892bfd81d8edfb49c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86bede1137574ee892bfd81d8edfb49c"}}, "title": "Rapid cytokine release assays for analysis of SARS-CoV-2-specific T cells in whole blood.", "authors": [{"family": "T\u00f6rnell", "given": "Andreas", "initials": "A", "orcid": "0000-0003-0769-2815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0e49354b88f4f7c8792dfb4216561c8.json"}}, {"family": "Grauers Wiktorin", "given": "Hanna", "initials": "H"}, {"family": "Ringlander", "given": "Johan", "initials": "J", "orcid": "0000-0002-8483-6504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64f85af7dceb436498422e62f1a98c89.json"}}, {"family": "Arabpour", "given": "Mohammad", "initials": "M"}, {"family": "Nilsson", "given": "Malin R", "initials": "MR"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Kiffin", "given": "Roberta", "initials": "R"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K"}, {"family": "Martner", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899", "volume": null, "issue": null, "pages": null}, "abstract": "Waning of IgG antibodies against SARS-CoV-2 complicates diagnosis of past infection. Durability of T cell memory against SARS-CoV-2 remains unclear, and most current T cell protocols are unsuited for large-scale automation.\r\n\r\nWhole blood samples from 31 patients with verified past COVID-19 and 46 controls, out of which 40 received SARS-CoV-2 vaccine were stimulated with peptides spanning the nucleocapsid (NC) or spike 1 (S1) regions of SARS-CoV-2 and analyzed for interferon-\u03b3 (IFN-\u03b3) in supernatant plasma. Diagnostic accuracy of these assays was evaluated against serum anti-NC and anti-receptor-binding domain S1 IgG.\r\n\r\nInduction of IFN-\u03b3 in whole blood by NC or S1 peptides diagnosed past COVID-19 with high accuracy (AUC=0.93, AUC=0.95, respectively). In accordance with previous studies, NC-IgG levels rapidly waned with only 5/17 patients (29%) remaining seropositive >180 days after infection. By contrast, NC-peptide-induced T cell memory responses remained in 13/17 (76%) subjects >180 days after infection (P=0.012 vs. NC-IgG, McNemar test). After two vaccine doses, 18/18 donors exhibited S1-specific T cell memory.\r\n\r\nCytokine release assays for the monitoring of T cell memory in whole blood may be useful for evaluation of complications following unverified past COVID-19 and for long-term assessment of vaccine-induced T cell immunity.", "doi": "10.1093/infdis/jiac005", "pmid": "35022764", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "6504009"}], "notes": [], "created": "2022-01-13T20:54:06.771Z", "modified": "2022-01-27T08:16:10.671Z"}, {"entity": "publication", "iuid": "1ebcd2295d00429aad5aa2b70d0e4584", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ebcd2295d00429aad5aa2b70d0e4584.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ebcd2295d00429aad5aa2b70d0e4584"}}, "title": "Melflufen or pomalidomide plus dexamethasone for patients with multiple myeloma refractory to lenalidomide (OCEAN): a randomised, head-to-head, open-label, phase 3 study.", "authors": [{"family": "Schjesvold", "given": "Fredrik H", "initials": "FH"}, {"family": "Dimopoulos", "given": "Meletios-Athanasios", "initials": "MA"}, {"family": "Delimpasi", "given": "Sosana", "initials": "S"}, {"family": "Robak", "given": "Pawel", "initials": "P"}, {"family": "Coriu", "given": "Daniel", "initials": "D"}, {"family": "Legiec", "given": "Wojciech", "initials": "W"}, {"family": "Pour", "given": "Lud\u011bk", "initials": "L"}, {"family": "\u0160pi\u010dka", "given": "Ivan", "initials": "I"}, {"family": "Masszi", "given": "Tamas", "initials": "T"}, {"family": "Doronin", "given": "Vadim", "initials": "V"}, {"family": "Minarik", "given": "Jiri", "initials": "J"}, {"family": "Salogub", "given": "Galina", "initials": "G"}, {"family": "Alekseeva", "given": "Yulia", "initials": "Y"}, {"family": "Lazzaro", "given": "Antonio", "initials": "A"}, {"family": "Maisnar", "given": "Vladimir", "initials": "V"}, {"family": "Mikala", "given": "G\u00e1bor", "initials": "G"}, {"family": "Rosi\u00f1ol", "given": "Laura", "initials": "L"}, {"family": "Liberati", "given": "Anna Marina", "initials": "AM"}, {"family": "Symeonidis", "given": "Argiris", "initials": "A"}, {"family": "Moody", "given": "Victoria", "initials": "V"}, {"family": "Thuresson", "given": "Marcus", "initials": "M"}, {"family": "Byrne", "given": "Catriona", "initials": "C"}, {"family": "Harmenberg", "given": "Johan", "initials": "J"}, {"family": "Bakker", "given": "Nicolaas A", "initials": "NA"}, {"family": "H\u00e1jek", "given": "Roman", "initials": "R"}, {"family": "Mateos", "given": "Maria-Victoria", "initials": "MV"}, {"family": "Richardson", "given": "Paul G", "initials": "PG"}, {"family": "Sonneveld", "given": "Pieter", "initials": "P"}, {"family": "OCEAN (OP-103) Investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "Lancet Haematol", "issn": "2352-3026", "issn-l": null}, "abstract": "Melphalan flufenamide (melflufen), an alkylating peptide-drug conjugate, plus dexamethasone showed clinical activity and manageable safety in the phase 2 HORIZON study. We aimed to determine whether melflufen plus dexamethasone would provide a progression-free survival benefit compared with pomalidomide plus dexamethasone in patients with previously treated multiple myeloma.\n\nIn this randomised, open-label, head-to-head, phase 3 study (OCEAN), adult patients (aged \u226518 years) were recruited from 108 university hospitals, specialist hospitals, and community-based centres in 21 countries across Europe, North America, and Asia. Eligible patients had an ECOG performance status of 0-2; must have had relapsed or refractory multiple myeloma, refractory to lenalidomide (within 18 months of randomisation) and to the last line of therapy; and have received two to four previous lines of therapy (including lenalidomide and a proteasome inhibitor). Patients were randomly assigned (1:1), stratified by age, number of previous lines of therapy, and International Staging System score, to either 28-day cycles of melflufen and dexamethasone (melflufen group) or pomalidomide and dexamethasone (pomalidomide group). All patients received dexamethasone 40 mg orally on days 1, 8, 15, and 22 of each cycle. In the melflufen group, patients received melflufen 40 mg intravenously over 30 min on day 1 of each cycle and in the pomalidomide group, patients received pomalidomide 4 mg orally daily on days 1 to 21 of each cycle. The primary endpoint was progression-free survival assessed by an independent review committee in the intention-to-treat (ITT) population. Safety was assessed in patients who received at least one dose of study medication. This study is registered with ClinicalTrials.gov, NCT03151811, and is ongoing.\n\nBetween June 12, 2017, and Sept 3, 2020, 246 patients were randomly assigned to the melflufen group (median age 68 years [IQR 60-72]; 107 [43%] were female) and 249 to the pomalidomide group (median age 68 years [IQR 61-72]; 109 [44%] were female). 474 patients received at least one dose of study drug (melflufen group n=228; pomalidomide group n=246; safety population). Data cutoff was Feb 3, 2021. Median progression-free survival was 6\u00b78 months (95% CI 5\u00b70-8\u00b75; 165 [67%] of 246 patients had an event) in the melflufen group and 4\u00b79 months (4\u00b72-5\u00b77; 190 [76%] of 249 patients had an event) in the pomalidomide group (hazard ratio [HR] 0\u00b779, [95% CI 0\u00b764-0\u00b798]; p=0\u00b7032), at a median follow-up of 15\u00b75 months (IQR 9\u00b74-22\u00b78) in the melflufen group and 16\u00b73 months (10\u00b71-23\u00b72) in the pomalidomide group. Median overall survival was 19\u00b78 months (95% CI 15\u00b71-25\u00b76) at a median follow-up of 19\u00b78 months (IQR 12\u00b70-25\u00b70) in the melflufen group and 25\u00b70 months (95% CI 18\u00b71-31\u00b79) in the pomalidomide group at a median follow-up of 18\u00b76 months (IQR 11\u00b78-23\u00b77; HR 1\u00b710 [95% CI 0\u00b785-1\u00b744]; p=0\u00b747). The most common grade 3 or 4 treatment-emergent adverse events were thrombocytopenia (143 [63%] of 228 in the melflufen group vs 26 [11%] of 246 in the pomalidomide group), neutropenia (123 [54%] vs 102 [41%]), and anaemia (97 [43%] vs 44 [18%]). Serious treatment-emergent adverse events occurred in 95 (42%) patients in the melflufen group and 113 (46%) in the pomalidomide group, the most common of which were pneumonia (13 [6%] vs 21 [9%]), COVID-19 pneumonia (11 [5%] vs nine [4%]), and thrombocytopenia (nine [4%] vs three [1%]). 27 [12%] patients in the melflufen group and 32 [13%] in the pomalidomide group had fatal treatment-emergent adverse events. Fatal treatment-emergent adverse events were considered possibly treatment related in two patients in the melflufen group (one with acute myeloid leukaemia, one with pancytopenia and acute cardiac failure) and four patients in the pomalidomide group (two patients with pneumonia, one with myelodysplastic syndromes, one with COVID-19 pneumonia).\n\nMelflufen plus dexamethasone showed superior progression-free survival than pomalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma.\n\nOncopeptides AB.", "doi": "10.1016/S2352-3026(21)00381-1", "pmid": "35032434", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2352-3026(21)00381-1"}, {"db": "ClinicalTrials.gov", "key": "NCT03151811"}], "notes": [], "created": "2022-01-27T08:01:51.013Z", "modified": "2022-01-27T08:02:32.941Z"}, {"entity": "publication", "iuid": "39bc0b2add3e4b35a4e165267c32aebd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/39bc0b2add3e4b35a4e165267c32aebd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/39bc0b2add3e4b35a4e165267c32aebd"}}, "title": "Hospital Admissions for Respiratory Tract Infections in Children Aged 0-5 Years for 2017/2023.", "authors": [{"family": "Methi", "given": "Fredrik", "initials": "F"}, {"family": "St\u00f8rdal", "given": "Ketil", "initials": "K"}, {"family": "Telle", "given": "Kjetil", "initials": "K"}, {"family": "Larsen", "given": "Vilde Bergstad", "initials": "VB"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "Front Pediatr", "issn": "2296-2360", "volume": "9", "pages": "822985", "issn-l": "2296-2360"}, "abstract": "Aim: To compare hospital admissions across common respiratory tract infections (RTI) in 2017-21, and project possible hospital admissions for the RTIs among children aged 0-12 months and 1-5 years in 2022 and 2023. Methods: In 644 885 children aged 0-12 months and 1-5 years, we plotted the observed monthly number of RTI admissions [upper- and lower RTI, influenza, respiratory syncytial virus (RSV), and COVID-19] from January 1st, 2017 until October 31st, 2021. We also plotted the number of RTI admissions with a need for respiratory support. We used the observed data to project four different scenarios of RTI admissions for the rest of 2021 until 2023, with different impacts on hospital wards: (1) \"Business as usual,\" (2) \"Continuous lockdown,\" (3) \"Children's immunity debt,\" and (4) \"Maternal and child immunity debt.\" Results: By October 31st, 2021, the number of simultaneous RTI admissions had exceeded the numbers usually observed at the typical season peak in January, i.e., ~900. Based on our observed data and assuming that children and their mothers (who transfer antibodies to the very youngest) have not been exposed to RTI over the last one and a half years, our scenarios suggest that hospitals should be prepared to handle two to three times as many RTI admissions, and two to three times as many RTI admissions requiring respiratory support among 0-5-year-olds as normal, from November 2021 to April 2022. Conclusion: Scenarios with immunity debt suggest that pediatric hospital wards and policy makers should plan for extended capacity.", "doi": "10.3389/fped.2021.822985", "pmid": "35096720", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8790534"}], "notes": [], "created": "2022-02-06T16:56:19.763Z", "modified": "2022-02-06T16:56:19.769Z"}, {"entity": "publication", "iuid": "4c9b95143255486b93902708459647f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4c9b95143255486b93902708459647f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4c9b95143255486b93902708459647f0"}}, "title": "Health care utilization following \"digi-physical\" assessment compared to physical assessment for infectious symptoms in primary care.", "authors": [{"family": "Entezarjou", "given": "Artin", "initials": "A"}, {"family": "Sj\u00f6beck", "given": "Maria", "initials": "M"}, {"family": "Midl\u00f6v", "given": "Patrik", "initials": "P"}, {"family": "Nymberg", "given": "Veronica Milos", "initials": "VM"}, {"family": "Vigren", "given": "Lina", "initials": "L"}, {"family": "Labaf", "given": "Ashkan", "initials": "A"}, {"family": "Jakobsson", "given": "Ulf", "initials": "U"}, {"family": "Calling", "given": "Susanna", "initials": "S"}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "BMC Prim Care", "issn": "2731-4553", "volume": "23", "pages": "4", "issn-l": null}, "abstract": "The use of chat-based digital visits (eVisits) to assess infectious symptoms in primary care is rapidly increasing. The \"digi-physical\" model of care uses eVisits as the first line of assessment while assuming a certain proportion of patients will inevitably need to be further assessed through urgent physical examination within 48 h. It is unclear to what extent this approach can mitigate physical visits compared to assessing patients directly using office visits.\n\nThis pre-COVID-19-pandemic observational study followed up \"digi-physical\" eVisit patients (n = 1188) compared to office visit patients (n = 599) with respiratory or urinary symptoms. Index visits occurred between March 30th 2016 and March 29th 2019. The primary outcome was subsequent physical visits to physicians within two weeks using registry data from Sk\u00e5ne county, Sweden (Region Sk\u00e5nes V\u00e5rddatabas, RSVD).\n\nNo significant differences in subsequent physical visits within two weeks (excluding the first 48 h) were noted following \"digi-physical\" care compared to office visits (179 (18.0%) vs. 102 (17.6%), P = .854). As part of the \"digital-physical\" concept, a significantly larger proportion of eVisit patients had a physical visit within 48 h compared to corresponding office visit patients (191 (16.1%) vs. 19 (3.2%), P < .001), with 150 (78.5%) of these eVisit patients recommended some form of follow-up by the eVisit physician.\n\nMost eVisit patients (68.9%) with respiratory and urinary symptoms have no subsequent physical visits. Beyond an unavoidable portion of patients requiring urgent physical examination within 48 h, \"digi-physical\" management of respiratory and urinary symptoms results in comparable subsequent health care utilization compared to office visits. eVisit providers may need to optimize use of resources to minimize the proportion of patients being assessed both digitally and physically within 48 h as part of the \"digi-physical\" concept.\n\nClinicaltrials.gov identifier: NCT03474887.\n\nThe online version contains supplementary material available at 10.1186/s12875-021-01618-2.", "doi": "10.1186/s12875-021-01618-2", "pmid": "35036998", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "1618"}, {"db": "pmc", "key": "PMC8753946"}, {"db": "ClinicalTrials.gov", "key": "NCT03474887"}], "notes": [], "created": "2022-01-27T07:38:39.967Z", "modified": "2022-01-27T07:38:40.002Z"}, {"entity": "publication", "iuid": "ec5b43c5579b48b993c1bde3ea0b43f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec5b43c5579b48b993c1bde3ea0b43f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec5b43c5579b48b993c1bde3ea0b43f1"}}, "title": "Europe must come together to confront omicron.", "authors": [{"family": "Health professionals and researchers from across Europe", "given": "", "initials": ""}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "376", "pages": "o90", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.o90", "pmid": "35027352", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2022-01-27T08:04:55.333Z", "modified": "2022-01-27T08:05:01.654Z"}, {"entity": "publication", "iuid": "ece53f8821f84bd69158ea993ccbb0ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ece53f8821f84bd69158ea993ccbb0ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ece53f8821f84bd69158ea993ccbb0ff"}}, "title": "Childhood cancer survivorship care during the COVID-19 pandemic: an international report of practice implications and provider concerns.", "authors": [{"family": "van den Oever", "given": "Selina R", "initials": "SR"}, {"family": "Pluijm", "given": "Saskia M F", "initials": "SMF"}, {"family": "Skinner", "given": "Rod", "initials": "R"}, {"family": "Glaser", "given": "Adam", "initials": "A"}, {"family": "Mulder", "given": "Ren\u00e9e L", "initials": "RL"}, {"family": "Armenian", "given": "Saro", "initials": "S"}, {"family": "Bardi", "given": "Edit", "initials": "E"}, {"family": "Berger", "given": "Claire", "initials": "C"}, {"family": "Ehrhardt", "given": "Matthew J", "initials": "MJ"}, {"family": "Gilleland Marchak", "given": "Jordan", "initials": "J"}, {"family": "Haeusler", "given": "Gabrielle M", "initials": "GM"}, {"family": "Hartogh", "given": "Jaap den", "initials": "JD"}, {"family": "Hjorth", "given": "Lars", "initials": "L"}, {"family": "Kepak", "given": "Tomas", "initials": "T"}, {"family": "Kriviene", "given": "Izolda", "initials": "I"}, {"family": "Langer", "given": "Thorsten", "initials": "T"}, {"family": "Maeda", "given": "Miho", "initials": "M"}, {"family": "M\u00e1rquez-Vega", "given": "Catalina", "initials": "C"}, {"family": "Michel", "given": "Gisela", "initials": "G"}, {"family": "Muraca", "given": "Monica", "initials": "M"}, {"family": "Najib", "given": "Mohamed", "initials": "M"}, {"family": "Nathan", "given": "Paul C", "initials": "PC"}, {"family": "Panasiuk", "given": "Anna", "initials": "A"}, {"family": "Prasad", "given": "Maya", "initials": "M"}, {"family": "Roganovic", "given": "Jelena", "initials": "J"}, {"family": "Uyttebroeck", "given": "Anne", "initials": "A"}, {"family": "Winther", "given": "Jeanette F", "initials": "JF"}, {"family": "Zadravec Zaletel", "given": "Lorna", "initials": "L"}, {"family": "van Dalen", "given": "Elvira C", "initials": "EC"}, {"family": "van der Pal", "given": "Helena J H", "initials": "HJH"}, {"family": "Hudson", "given": "Melissa M", "initials": "MM"}, {"family": "Kremer", "given": "Leontien C M", "initials": "LCM"}, {"family": "IGHG COVID-19 working group", "given": "", "initials": ""}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "J Cancer Surviv", "issn": "1932-2267", "issn-l": null}, "abstract": "Long-term follow-up (LTFU) care is essential to optimise health outcomes in childhood cancer survivors (CCS). We aimed to assess the impact of the COVID-19 pandemic on LTFU services and providers.\n\nA COVID-19 working group within the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) distributed a questionnaire to LTFU service providers in 37 countries across Europe, Asia, North America, Central/South America, and Australia. The questionnaire assessed how care delivery methods changed during the pandemic and respondents' level of worry about the pandemic's impact on LTFU care delivery, their finances, their health, and that of their family and friends.\n\nAmong 226 institutions, providers from 178 (79%) responded. Shortly after the initial outbreak, 42% of LTFU clinics closed. Restrictions during the pandemic resulted in fewer in-person consultations and an increased use of telemedicine, telephone, and email consultations. The use of a risk assessment to prioritise the method of LTFU consultation for individual CCS increased from 12 to 47%. While respondents anticipated in-person consultations to remain the primary method for LTFU service delivery, they expected significantly increased use of telemedicine and telephone consultations after the pandemic. On average, respondents reported highest levels of worry about psychosocial well-being of survivors.\n\nThe pandemic necessitated changes in LTFU service delivery, including greater use of virtual LTFU care and risk-stratification to identify CCS that need in-person evaluations.\n\nIncreased utilisation of virtual LTFU care and risk stratification is likely to persist post-pandemic.", "doi": "10.1007/s11764-021-01120-9", "pmid": "35020136", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11764-021-01120-9"}], "notes": [], "created": "2022-01-13T20:59:59.684Z", "modified": "2022-01-13T20:59:59.713Z"}, {"entity": "publication", "iuid": "0adb863d25c64639a287d0914a64f96c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0adb863d25c64639a287d0914a64f96c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0adb863d25c64639a287d0914a64f96c"}}, "title": "BMI in early adulthood is associated with severe COVID-19 later in life - a prospective cohort study of 1.5 million Swedish men.", "authors": [{"family": "Robertson", "given": "Josefina", "initials": "J", "orcid": "0000-0002-2167-6822", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b16ed75f7eb4950beacd818fe23d5e5.json"}}, {"family": "Adiels", "given": "Martin", "initials": "M"}, {"family": "Lissner", "given": "Lauren", "initials": "L"}, {"family": "Mehlig", "given": "Kirsten", "initials": "K"}, {"family": "Af Geijerstam", "given": "Agnes", "initials": "A"}, {"family": "Lindgren", "given": "Martin", "initials": "M"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Ekblom Bak", "given": "Elin", "initials": "E"}, {"family": "Rosengren", "given": "Annika", "initials": "A"}, {"family": "\u00c5berg", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "Obesity (Silver Spring)", "issn": "1930-739X", "issn-l": null}, "abstract": "Overweight and obesity have been identified as risk factors for severe COVID-19, however, prospective cohort studies investigating the association between overweight early in life and severity of COVID-19 are lacking.\n\nWe included 1,551,670 Swedish men, born 1950-1987, with body mass index (BMI) registered at age 18. They were followed until January 9, 2021. COVID-19 cases and comorbidities were identified through the National Patient, Intensive Care, and Cause of Death registries. Outcomes were: 1) hospitalization, 2) intensive care unit admission, and 3) death.\n\nWe found 4,315 cases (mean age 56.4 years, SD 8.8) hospitalized due to COVID-19, of which 729 were admitted to an intensive care unit, and altogether 224 deaths. The risk for hospital admission increased with higher values of BMI (kg/m2 ), despite adjustment for comorbidities, from odds ratio (OR) 1.19 (95% CI 1.08-1.31) at BMI 22.5-25 to 1.68 (1.39-2.02) at BMI \u226530 compared to BMI 18.5-20. ORs for intensive care unit admission were 1.44 (1.13-1.84) at BMI 22.5-25 and 2.61 (1.73-3.93) at BMI \u226530.\n\nHigher BMI in early adulthood was associated with severe COVID-19 many years later with a risk increase starting already at BMI \u226522.5. This underlines the necessity of preventive actions against overweight in youth to offer protection against coming viral pandemics.", "doi": "10.1002/oby.23378", "pmid": "35023305", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-01-13T20:53:28.070Z", "modified": "2022-01-27T08:15:25.788Z"}, {"entity": "publication", "iuid": "b9613c0c5cab4be28151d60193f28d1c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9613c0c5cab4be28151d60193f28d1c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9613c0c5cab4be28151d60193f28d1c"}}, "title": "A first remotely-delivered guided brief intervention to reduce intrusive memories of psychological trauma for healthcare staff working during the ongoing COVID-19 pandemic: Study protocol for a randomised controlled trial.", "authors": [{"family": "Singh", "given": "Laura", "initials": "L"}, {"family": "Kanstrup", "given": "Marie", "initials": "M"}, {"family": "Gamble", "given": "Beau", "initials": "B"}, {"family": "Geranmayeh", "given": "Anahita", "initials": "A"}, {"family": "G\u00f6ransson", "given": "Katarina E", "initials": "KE"}, {"family": "Rudman", "given": "Ann", "initials": "A"}, {"family": "Dahl", "given": "Oili", "initials": "O"}, {"family": "Lindstr\u00f6m", "given": "Veronica", "initials": "V"}, {"family": "H\u00f6rberg", "given": "Anna", "initials": "A"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}, {"family": "Moulds", "given": "Michelle L", "initials": "ML"}], "type": "journal article", "published": "2022-01-12", "journal": {"title": "Contemp Clin Trials Commun", "issn": "2451-8654", "pages": "100884", "issn-l": null}, "abstract": "Addressing the mental health needs of healthcare staff exposed to psychologically traumatic events at work during the COVID-19 pandemic is a pressing global priority. We need to swiftly develop interventions to target the psychological consequences (e.g., persistent intrusive memories of trauma). Interventions for healthcare staff must be brief, flexible, fitted around the reality and demands of working life under the pandemic, and repeatable during ongoing/further trauma exposure. Intervention delivery during the pandemic should be remote to mitigate risk of infection; e.g., here using a blend of digitalized self-administered materials (e.g., video instructions) and guided (remote) support from a researcher. This parallel groups, two-arm, randomised controlled trial (RCT) with healthcare staff working during the COVID-19 pandemic is the first evaluation of whether a digitalized form of a brief cognitive task intervention, which is remotely-delivered (guided), reduces intrusive memories. Healthcare staff (target N = 130 completers) who experience intrusive memories of work-related traumatic event(s) during the COVID-19 pandemic (\u22652 in the week before inclusion) will be randomly allocated (1:1) to receive either the cognitive task intervention or an active (attention placebo) control, and followed up at 1-week, 1-month, 3-months, and 6-months post-intervention. The primary outcome will be the number of intrusive memories reported during Week 5; secondary and other outcomes include the number of intrusive memories reported during Week 1, and other intrusive symptoms. Findings will inform further development and dissemination of a brief cognitive task intervention to target intrusive memories.", "doi": "10.1016/j.conctc.2022.100884", "pmid": "35036626", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2451-8654(22)00001-1"}, {"db": "pmc", "key": "PMC8752164"}], "notes": [], "created": "2022-01-27T07:39:12.779Z", "modified": "2022-01-27T07:39:12.815Z"}, {"entity": "publication", "iuid": "15ab40122fc94d8b978a421f3b54face", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15ab40122fc94d8b978a421f3b54face.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15ab40122fc94d8b978a421f3b54face"}}, "title": "The local and global mental health effects of the Covid-19 pandemic.", "authors": [{"family": "Akay", "given": "Alpaslan", "initials": "A"}], "type": "journal article", "published": "2022-01-11", "journal": {"title": "Econ Hum Biol", "issn": "1873-6130", "volume": "45", "pages": "101095", "issn-l": null}, "abstract": "This paper investigates the mental health effects of the local and global level Covid-19 pandemic among the UK population. To identify the effect, we use a high-quality dataset and an original strategy where we match the previous day's confirmed pandemic cases to a four-month panel of individual mental health information observed during the interview next day. The approach suggested in this paper aims to identify the average mental health effect on the overall population for the first and second waves of the pandemic. Using a linear fixed-effects model specification, we report robust findings that the average mental health in the UK is substantially reduced by the local and global pandemic. The total reduction in the average mental health of the UK population during our sampling period (April - June, 2020) is about 1.5% for the local and 2.4% for the global cases, which sum up to a 3.9% reduction. Extrapolating the total reduction in average mental health during the first wave of the pandemic (February - September, 2020) sums up to 2.8% while the effect is as large as 9.6% for the first and second waves together, which covers roughly a year since the start. An extensive robustness check suggests that the findings are stable with respect to alternative pandemic datasets, measures, estimators, functional forms, and time functions. The characteristics of the most vulnerable individuals (e.g., elderly, chronic illness, and job security concerns) and their household conditions (e.g., living alone and no private space) are explored. The paper discusses on the implications of the results.", "doi": "10.1016/j.ehb.2021.101095", "pmid": "35092869", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1570-677X(21)00120-9"}, {"db": "pmc", "key": "PMC8750697"}], "notes": [], "created": "2022-01-31T11:40:41.594Z", "modified": "2022-02-06T17:07:27.067Z"}, {"entity": "publication", "iuid": "257c8ebf09e843069de1b8dda587e433", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/257c8ebf09e843069de1b8dda587e433.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/257c8ebf09e843069de1b8dda587e433"}}, "title": "Swallowing function in COVID-19 patients after invasive mechanical ventilation.", "authors": [{"family": "Lindh", "given": "Margareta Gonzalez", "initials": "MG"}, {"family": "Mattsson", "given": "Gustav", "initials": "G"}, {"family": "Koyi", "given": "Hirsh", "initials": "H"}, {"family": "Johansson", "given": "Monica Blom", "initials": "MB"}, {"family": "Razmi", "given": "Robin", "initials": "R"}, {"family": "Palm", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2022-01-11", "journal": {"title": "Arch Rehabil Res Clin Transl", "issn": "2590-1095", "pages": "100177", "issn-l": null}, "abstract": "To explore swallowing function and risk factors associated with delayed recovery of swallowing in COVID-19 patients post invasive mechanical ventilation using the Functional Oral Intake Scale (FOIS).\n\nLongitudinal cohort study.\n\n3 secondary-level hospitals.\n\nInvasively ventilated patients (n=28), hospitalized with severe COVID-19 who were referred to the Speech and Language Pathology (SLP) departments post mechanical ventilation between March 5 and July 5 2020 for an evaluation of swallowing function before commencing oral diet.\n\nSLP assessment, advice and therapy for dysphagia.\n\nOral intake levels at baseline and hospital discharge according to the Functional Oral Intake Scale (FOIS). Patients were stratified according to FOIS (1-5=dysphagia, 6-7= functional oral intake). Data regarding comorbidities, frailty, intubation and tracheostomy, proning and SLP evaluation were collected.\n\nDysphagia was found in 71% of the patients at baseline (in total 79% male, age 61 \u00b112 years, BMI 30 \u00b18 kg/m2). Median FOIS score at baseline was 2 (IQR 1) vs 5 (IQR 2.5) at hospital discharge. Patients with dysphagia were older (64 \u00b18.5 vs 53 \u00b116 years; p= 0.019), had a higher incidence of hypertension (70% vs 12%; p=0.006) were ventilated invasively longer (16 \u00b17 vs 10 \u00b12 days; p=0.017) or with tracheostomy (9 \u00b19 vs 1 \u00b12 days; p=0.03) longer. A negative association was found between swallowing dysfunction at bedside and days hospitalized (r=-0.471, p=0.01), and number of days at the Intensive Care Unit (ICU) (r=-0.48, p=0.01).\n\nDysphagia is prevalent in COVID-19 patients post invasive mechanical ventilation and is associated with number of days in hospital and number of days in the ICU. Swallowing function and tolerance of oral diet improved at discharge (p<0.001).", "doi": "10.1016/j.arrct.2021.100177", "pmid": "35036903", "labels": {"Category: Health": null, "Topics: Register-based research": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2590-1095(21)00093-8"}, {"db": "pmc", "key": "PMC8748224"}], "notes": [], "created": "2022-01-27T07:38:50.922Z", "modified": "2022-01-27T07:38:50.958Z"}, {"entity": "publication", "iuid": "15da31ac86004e92b1ec0cb6dae07880", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15da31ac86004e92b1ec0cb6dae07880.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15da31ac86004e92b1ec0cb6dae07880"}}, "title": "Preclinical evaluation of [11C]GW457427 as a tracer for neutrophil elastase.", "authors": [{"family": "Estrada", "given": "Sergio", "initials": "S"}, {"family": "Elgland", "given": "Mathias", "initials": "M"}, {"family": "Selvaraju", "given": "Ram Kumar", "initials": "RK"}, {"family": "Mani", "given": "Kevin", "initials": "K"}, {"family": "Tegler", "given": "Gustaf", "initials": "G"}, {"family": "Wanhainen", "given": "Anders", "initials": "A"}, {"family": "W\u00e5gs\u00e4ter", "given": "Dick", "initials": "D"}, {"family": "Bergstr\u00f6m", "given": "Mats", "initials": "M"}, {"family": "Jimenez-Royo", "given": "Pilar", "initials": "P"}, {"family": "Jahan", "given": "Mahabuba", "initials": "M"}, {"family": "Nordeman", "given": "Patrik", "initials": "P"}, {"family": "Antoni", "given": "Gunnar", "initials": "G"}], "type": "journal article", "published": "2022-01-11", "journal": {"title": "Nucl Med Biol", "issn": "1872-9614", "volume": "106-107", "pages": "62-71", "issn-l": null}, "abstract": "Neutrophils are part of the innate immune system and function as a first line of defense against invading microorganisms. Overactivity of the immune system may result in a devastating immuno-inflammation with extensive damage to tissue leading to organ damage and/or failure. The literature suggests several human diseases in which neutrophil elastase (NE) is postulated to be important in the pathophysiology including inflammatory bowel disease (IBD), chronic obstructive pulmonary disorder (COPD), abdominal aortic aneurysms (AAA), breast and lung cancer, and recently also in Sars-cov-2 virus infection (Covid-19). In particular, the lungs are affected by the destructive power of the protease neutrophil elastase (NE). In this paper, we report the pre-clinical development of a selective and specific positron emission tomography (PET) tracer, [11C]GW457427, as an in vivo biomarker for the study of NE, now available for human studies.\n\n[11C]GW457427 was produced by methylation of GW447631 using [11C]methyl triflate and GMP validated production and quality control methods were developed. Chemical purity was high with no traces of the precursor GW611437 or other uv-absorbing compounds. A method for the determination of intact [11C]GW457427 in plasma was developed and the binding characteristics were evaluated in vitro and in vivo. An animal model for lung inflammation was used to investigate the specificity and sensitivity of the [11C]GW457427 tracer for neutrophil elastase (NE) in pulmonary inflammation, verified by blockade using two structurally different elastase inhibitors.\n\n[11C]GW457427 was obtained in approximately 45% radiochemical yield and with a radiochemical purity higher than 98%. Molar activity was in the range 130-360 GBq/\u03bcmol. Binding to NE was shown to be highly specific both in vitro and in vivo and a significantly higher uptake of tracer was found in a lipopolysaccharide mouse model of pulmonary inflammation compared with control animals. The uptake in lung tissue measured as standardized uptake value (SUV) strongly correlated with tissue NE content as measured by ELISA. In vitro studies also showed specific tracer binding in aortic tissue of patients with abdominal aorta aneurysm (AAA). The rate of metabolism in rats was appropriate considering the critical balance between available tracer for binding and requirement for blood clearance with about 40% and 20% intact [11C]GW457427 in plasma at 5 and 40 min, respectively. Radioactivity was cleared from blood and organs in control animals with mainly hepatobiliary excretion with distribution in the intestines and the urinary bladder; but without retention of the tracer in healthy organs of interests such as the lung, liver, kidneys or in the cardiovascular system. A dosimetry study in rat indicated that the whole-body effective dose was 2.2 \u03bcSv/MBq with bone marrow as the limiting organ. It is estimated that up to five PET-CT investigations could be performed in humans without exceeding a total dose of 10 mSv.\n\n[11C]GW457427 is a promising in vivo PET-biomarker for NE with high specific binding demonstrated both in vitro and in vivo. A GMP validated production method including quality control has been developed and a microdosing toxicity study performed with no adverse signs. [11C]GW457427 is currently being evaluated in a First-In-Man PET study.", "doi": "10.1016/j.nucmedbio.2022.01.001", "pmid": "35066391", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0969-8051(22)00001-4"}], "notes": [], "created": "2022-01-26T10:17:17.214Z", "modified": "2022-01-26T10:17:17.250Z"}, {"entity": "publication", "iuid": "ed70688f95074af8a1fea26b7f1e2959", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed70688f95074af8a1fea26b7f1e2959.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed70688f95074af8a1fea26b7f1e2959"}}, "title": "Nordic responses to covid-19 from a health promotion perspective.", "authors": [{"family": "Thualagant", "given": "Nicole", "initials": "N", "orcid": "0000-0002-5197-8979", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d68eb2cd38d64995bb48f0354726c6fd.json"}}, {"family": "Simonsen", "given": "Nina", "initials": "N", "orcid": "0000-0003-1376-7588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/862fdf76669f44b7b1ddea945c3a5953.json"}}, {"family": "Sarvim\u00e4ki", "given": "Anneli", "initials": "A"}, {"family": "Stenbock-Hult", "given": "Bettina", "initials": "B"}, {"family": "Olafsdottir", "given": "Helga S", "initials": "HS"}, {"family": "Fosse", "given": "Elisabeth", "initials": "E"}, {"family": "Torp", "given": "Steffen", "initials": "S"}, {"family": "Ringsberg", "given": "Karin C", "initials": "KC"}, {"family": "Forrinder", "given": "Ulla", "initials": "U"}, {"family": "Tillgren", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2022-01-11", "journal": {"issn": "1460-2245", "title": "Health Promot Int", "issn-l": null}, "abstract": "On 30 January 2020, the disease covid-19 was declared by the World Health Organization to be an international threat to human health and on 11 March 2020, the outbreak was declared a pandemic. The aim of this study was to analyse policy strategies developed by the five Nordic countries during the first 3 months of the pandemic from a health promotion perspective in order to identify Nordic responses to the crisis. Although the Nordic countries have a long tradition of co-operation as well as similar social welfare policies and legislation, each country developed their own strategies towards the crisis. The strategies identified were analysed from a health promotion perspective emanating from five principles: intersectorality, sustainability, equity, empowerment and a lifecourse perspective. Denmark, Finland and Norway had lockdowns to varying degrees, whereas Sweden and Iceland had no lockdowns. Iceland implemented a test and tracking strategy from the very beginning. All countries based their recommendations and restrictions on appeals to solidarity and trust in institutions and fellow citizens. The analysis showed that the strategies in all countries could be related to health promotion principles with some differences between the countries especially regarding equity and sustainability. The Nordic governments took responsibility for protecting their citizens by developing policy strategies based on restrictions and recommendations congruent with the principles of health promotion. The findings also identified issues that will pose challenges for future pandemic strategies.", "doi": "10.1093/heapro/daab211", "pmid": "35022714", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6503709"}], "notes": [], "created": "2022-01-13T20:54:40.485Z", "modified": "2022-01-27T08:16:28.127Z"}, {"entity": "publication", "iuid": "8dff9cc6d4b04c53ac781df81a4b0ac9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8dff9cc6d4b04c53ac781df81a4b0ac9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8dff9cc6d4b04c53ac781df81a4b0ac9"}}, "title": "Lessons from COVID-19 for managing transboundary climate risks and building resilience.", "authors": [{"family": "Ringsmuth", "given": "Andrew K", "initials": "AK"}, {"family": "Otto", "given": "Ilona M", "initials": "IM"}, {"family": "van den Hurk", "given": "Bart", "initials": "B"}, {"family": "Lahn", "given": "Glada", "initials": "G"}, {"family": "Reyer", "given": "Christopher P O", "initials": "CPO"}, {"family": "Carter", "given": "Timothy R", "initials": "TR"}, {"family": "Magnuszewski", "given": "Piotr", "initials": "P"}, {"family": "Monasterolo", "given": "Irene", "initials": "I"}, {"family": "Aerts", "given": "Jeroen C J H", "initials": "JCJH"}, {"family": "Benzie", "given": "Magnus", "initials": "M"}, {"family": "Campiglio", "given": "Emanuele", "initials": "E"}, {"family": "Fronzek", "given": "Stefan", "initials": "S"}, {"family": "Gaupp", "given": "Franziska", "initials": "F"}, {"family": "Jarzabek", "given": "Lukasz", "initials": "L"}, {"family": "Klein", "given": "Richard J T", "initials": "RJT"}, {"family": "Knaepen", "given": "Hanne", "initials": "H"}, {"family": "Mechler", "given": "Reinhard", "initials": "R"}, {"family": "Mysiak", "given": "Jaroslav", "initials": "J"}, {"family": "Sillmann", "given": "Jana", "initials": "J"}, {"family": "Stuparu", "given": "Dana", "initials": "D"}, {"family": "West", "given": "Chris", "initials": "C"}], "type": "journal article", "published": "2022-01-11", "journal": {"title": "Clim Risk Manag", "issn": "2212-0963", "pages": "100395", "issn-l": null}, "abstract": "COVID-19 has revealed how challenging it is to manage global, systemic and compounding crises. Like COVID-19, climate change impacts, and maladaptive responses to them, have potential to disrupt societies at multiple scales via networks of trade, finance, mobility and communication, and to impact hardest on the most vulnerable. However, these complex systems can also facilitate resilience if managed effectively. This review aims to distil lessons related to the transboundary management of systemic risks from the COVID-19 experience, to inform climate change policy and resilience building. Evidence from diverse fields is synthesised to illustrate the nature of systemic risks and our evolving understanding of resilience. We describe research methods that aim to capture systemic complexity to inform better management practices and increase resilience to crises. Finally, we recommend specific, practical actions for improving transboundary climate risk management and resilience building. These include mapping the direct, cross-border and cross-sectoral impacts of potential climate extremes, adopting adaptive risk management strategies that embrace heterogenous decision-making and uncertainty, and taking a broader approach to resilience which elevates human wellbeing, including societal and ecological resilience.", "doi": "10.1016/j.crm.2022.100395", "pmid": "35036298", "labels": {"Topics: Register-based research": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2212-0963(22)00002-X"}, {"db": "pmc", "key": "PMC8750828"}], "notes": [], "created": "2022-01-27T07:39:29.268Z", "modified": "2022-01-27T07:39:29.304Z"}, {"entity": "publication", "iuid": "2fb6bea55079411390651ca203fab727", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2fb6bea55079411390651ca203fab727.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2fb6bea55079411390651ca203fab727"}}, "title": "Fighting the COVID pandemic: national policy choices in non-pharmaceutical interventions.", "authors": [{"family": "Alfano", "given": "Vincenzo", "initials": "V"}, {"family": "Ercolano", "given": "Salvatore", "initials": "S"}, {"family": "Pinto", "given": "Mauro", "initials": "M"}], "type": "journal article", "published": "2022-01-11", "journal": {"title": "J Policy Model", "issn": "0161-8938", "issn-l": null}, "abstract": "The COVID-19 pandemic pushed countries to adopt various non-pharmaceutical interventions (NPIs). Due to the features of the pandemic, which spread over time and space, governments could decide whether or not to follow policy choices made by leaders of countries affected by the virus before them. In this study, we aim to empirically model the adoption of NPIs during the first wave of COVID-19 in the 14 European countries with more than 10 million inhabitants, in order to detect whether a policy diffusion mechanism occurred. By means of a multivariate approach based on Principal Component Analysis and Cluster Analysis, we manage to derive three clusters representing different behaviour models to which the different European countries belong in the different periods of the first wave: pre-pandemic, summer relaxation and deep-lockdown scenarios. These results bring a two-fold contribution: on the one hand, they may help us to understand differences and similarities among European countries during the first wave of the COVID-19 outbreak and guide future quantitative or qualitative studies; on the other, our findings suggest that with minor exceptions (such as Sweden and Poland), different countries adopted very similar policy strategies, which are likely to be due more to the unfolding of the pandemic than to specific governmental strategies.", "doi": "10.1016/j.jpolmod.2021.11.003", "pmid": "35034999", "labels": {"Topics: Register-based research": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0161-8938(22)00001-1"}, {"db": "pmc", "key": "PMC8750834"}], "notes": [], "created": "2022-01-27T07:40:32.473Z", "modified": "2022-01-27T07:40:32.509Z"}, {"entity": "publication", "iuid": "8c5a03884ef049498703cc650b5f7eab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c5a03884ef049498703cc650b5f7eab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c5a03884ef049498703cc650b5f7eab"}}, "title": "COVID vaccine-induced pustular psoriasis in patients with previous plaque type psoriasis.", "authors": [{"family": "Piccolo", "given": "Vincenzo", "initials": "V", "orcid": "0000-0001-7798-4368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1ddb3ce197e446dbc8156e8e3222d5e.json"}}, {"family": "Russo", "given": "Teresa", "initials": "T"}, {"family": "Mazzatenta", "given": "Carlo", "initials": "C"}, {"family": "Bassi", "given": "Andrea", "initials": "A", "orcid": "0000-0002-9157-5189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2628d4790c0041b19e8bf037d259ed99.json"}}, {"family": "Argenziano", "given": "Giuseppe", "initials": "G"}, {"family": "Cutrone", "given": "Mario", "initials": "M"}, {"family": "Danielsson Darlington", "given": "Markus", "initials": "M"}, {"family": "Grimalt", "given": "Ramon", "initials": "R"}], "type": "letter", "published": "2022-01-11", "journal": {"title": "J Eur Acad Dermatol Venereol", "issn": "1468-3083", "issn-l": null}, "abstract": null, "doi": "10.1111/jdv.17918", "pmid": "35015916", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-13T21:04:00.367Z", "modified": "2022-01-13T21:04:00.457Z"}, {"entity": "publication", "iuid": "e291a0aa78b34963944fabe6c12277b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e291a0aa78b34963944fabe6c12277b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e291a0aa78b34963944fabe6c12277b1"}}, "title": "A Global Map of COVID-19 Vaccine Acceptance Rates per Country: An Updated Concise Narrative Review.", "authors": [{"family": "Sallam", "given": "Malik", "initials": "M", "orcid": "0000-0002-0165-9670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb490d3ed32f4b76b8a39bd0320bd748.json"}}, {"family": "Al-Sanafi", "given": "Mariam", "initials": "M", "orcid": "0000-0002-1366-3693", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dd8ddbcd9bc49c486fecaa5be0bc2bf.json"}}, {"family": "Sallam", "given": "Mohammed", "initials": "M", "orcid": "0000-0003-3273-524X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d118dbd1d1b4619b46af0480b8670f2.json"}}], "type": "journal article", "published": "2022-01-11", "journal": {"title": "J Multidiscip Healthc", "issn": "1178-2390", "volume": "15", "pages": "21-45", "issn-l": null}, "abstract": "The delay or refusal of vaccination, which defines vaccine hesitancy, is a major challenge to successful control of COVID-19 epidemic. The huge number of publications addressing COVID-19 vaccine hesitancy necessitates periodic review to provide a concise summary of COVID-19 vaccine acceptance rates worldwide. In the current narrative review, data on COVID-19 vaccine acceptance rates were retrieved from surveys in 114 countries/territories. In East and Southern Africa (n = 9), the highest COVID-19 vaccine acceptance rate was reported in Ethiopia (92%), while the lowest rate was reported in Zimbabwe (50%). In West/Central Africa (n = 13), the highest rate was reported in Niger (93%), while the lowest rate was reported in Cameroon (15%). In Asia and the Pacific (n = 16), the highest rates were reported in Nepal and Vietnam (97%), while the lowest rate was reported in Hong Kong (42%). In Eastern Europe/Central Asia (n = 7), the highest rates were reported in Montenegro (69%) and Kazakhstan (64%), while the lowest rate was reported in Russia (30%). In Latin America and the Caribbean (n = 20), the highest rate was reported in Mexico (88%), while the lowest rate was reported in Haiti (43%). In the Middle East/North Africa (MENA, n = 22), the highest rate was reported in Tunisia (92%), while the lowest rate was reported in Iraq (13%). In Western/Central Europe and North America (n = 27), the highest rates were reported in Canada (91%) and Norway (89%), while the lowest rates were reported in Cyprus and Portugal (35%). COVID-19 vaccine acceptance rates \u226560% were seen in 72/114 countries/territories, compared to 42 countries/territories with rates between 13% and 59%. The phenomenon of COVID-19 vaccine hesitancy appeared more pronounced in the MENA, Europe and Central Asia, and Western/Central Africa. More studies are recommended in Africa, Eastern Europe and Central Asia to address intentions of the general public to get COVID-19 vaccination.", "doi": "10.2147/JMDH.S347669", "pmid": "35046661", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "347669"}, {"db": "pmc", "key": "PMC8760993"}], "notes": [], "created": "2022-01-27T07:03:42.486Z", "modified": "2022-01-27T07:03:42.581Z"}, {"entity": "publication", "iuid": "e03da05d0d4141368fbdd11d9def96c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e03da05d0d4141368fbdd11d9def96c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e03da05d0d4141368fbdd11d9def96c9"}}, "title": "Trials and Treatments for Vascular Brain Health: Risk Factor Modification and Cognitive Outcomes.", "authors": [{"family": "Kivipelto", "given": "Miia", "initials": "M", "orcid": "0000-0003-0992-3875", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4fcc583c88c24eb58c1a17bae81d4668.json"}}, {"family": "Palmer", "given": "Katie", "initials": "K", "orcid": "0000-0001-8783-016X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d6ec60063a647308b02d7fd8f72a1b7.json"}}, {"family": "Hoang", "given": "Tina D", "initials": "TD"}, {"family": "Yaffe", "given": "Kristine", "initials": "K", "orcid": "0000-0003-0919-3825", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/827527252aca469880c3424682107e4d.json"}}], "type": "journal article", "published": "2022-01-10", "journal": {"title": "Stroke", "issn": "1524-4628", "pages": "STROKEAHA121032614", "issn-l": null}, "abstract": "There is robust evidence linking vascular health to brain health, cognition, and dementia. In this article, we present evidence from trials of vascular risk factor treatment on cognitive outcomes. We summarize findings from randomized controlled trials of antihypertensives, lipid-lowering medications, diabetes treatments (including antidiabetic drugs versus placebo, and intensive versus standard glycemic control), and multidomain interventions (that target several domains simultaneously such as control of vascular and metabolic factors, nutrition, physical activity, and cognitive stimulation etc). We report that evidence on the efficacy of vascular risk reduction interventions is promising, but not yet conclusive, and several methodological limitations hamper interpretation. Evidence mainly comes from high-income countries and, as cognition and dementia have not been the primary outcomes of many trials, evaluation of cognitive changes have often been limited. As the cognitive aging process occurs over decades, it is unclear whether treatment during the late-life window is optimal for dementia prevention, yet older individuals have been the target of most trials thus far. Further, many trials have not been powered to explore interactions with modifiers such as age, race, and apolipoprotein E, even though sub-analyses from some trials indicate that the success of interventions differs depending on patient characteristics. Due to the complex multifactorial etiology of dementia, and variations in risk factors between individuals, multidomain interventions targeting several risk factors and mechanisms are likely to be needed and the long-term sustainability of preventive interventions will require personalized approaches that could be facilitated by digital health tools. This is especially relevant during the coronavirus disease 2019 (COVID-19) pandemic, where intervention strategies will need to be adapted to the new normal, when face-to-face engagement with participants is limited and public health measures may create changes in lifestyle that affect individuals' vascular risk profiles and subsequent risk of cognitive decline.", "doi": "10.1161/STROKEAHA.121.032614", "pmid": "35000424", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-13T21:12:39.205Z", "modified": "2022-01-13T21:12:53.206Z"}, {"entity": "publication", "iuid": "b05d09cb683c41b095a9898e26e93670", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b05d09cb683c41b095a9898e26e93670.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b05d09cb683c41b095a9898e26e93670"}}, "title": "Repurposing of Medicines in the EU: Launch of a Pilot Framework.", "authors": [{"family": "Asker-Hagelberg", "given": "Charlotte", "initials": "C"}, {"family": "Boran", "given": "Tomas", "initials": "T"}, {"family": "Bouygues", "given": "Christelle", "initials": "C"}, {"family": "Eskola", "given": "Sini Marika", "initials": "SM"}, {"family": "Helmle", "given": "Laszlo", "initials": "L"}, {"family": "Hern\u00e1ndez", "given": "C\u00e9sar", "initials": "C"}, {"family": "Hou\u00fdez", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Lee", "given": "Helen", "initials": "H"}, {"family": "Lingri", "given": "Dimitra D", "initials": "DD"}, {"family": "Louette", "given": "Laurent", "initials": "L"}, {"family": "Meheus", "given": "Lydie", "initials": "L"}, {"family": "Penninckx", "given": "Wim", "initials": "W"}, {"family": "Stepniewska", "given": "Beata", "initials": "B"}], "type": "journal article", "published": "2022-01-10", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "8", "pages": "817663", "issn-l": null}, "abstract": "Repurposing of authorised medicines has been under discussion for a long time. Drug repurposing is the process of identifying a new use for an existing medicine in an indication outside the scope of the original approved indication. Indeed, the COVID-19 health crisis has brought the concept to the frontline by proving the usefulness of this practise in favour of patients for an early access to treatment. Under the umbrella of the Pharmaceutical Committee and as a result of the discussions at the European Commission Expert Group on Safe and Timely Access to Medicines for Patients (STAMP) a virtual Repurposing Observatory Group (RepOG) was set up in 2019 to define and test the practical aspects of a pilot project thought to provide support to \"not-for-profit\" stakeholders generating or gathering data for a new therapeutic use for an authorised medicine. The group's initial plan was impacted by the outbreak of the SARS-CoV-2 pandemic and the launch of the pilot needed to be postponed. This article describes the progress and the activities conducted by the group during this past and yet extraordinary 2020-2021 to keep the project alive and explores on the background of this topic together with the obvious opportunities this health crisis has brought up in terms of repurposing of medicines.", "doi": "10.3389/fmed.2021.817663", "pmid": "35083258", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8784735"}], "notes": [], "created": "2022-01-31T11:48:41.243Z", "modified": "2022-01-31T11:48:41.256Z"}, {"entity": "publication", "iuid": "47d3fbe67a97499d8273b9ea33b939d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47d3fbe67a97499d8273b9ea33b939d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47d3fbe67a97499d8273b9ea33b939d7"}}, "title": "Heroes, victims, and villains in news media narratives about COVID-19. Analysing moralising discourse in Swedish newspaper reporting during the spring of 2020.", "authors": [{"family": "Skog", "given": "Frida", "initials": "F"}, {"family": "Lundstr\u00f6m", "given": "Ragnar", "initials": "R"}], "type": "journal article", "published": "2022-01-10", "journal": {"title": "Soc Sci Med", "issn": "1873-5347", "issn-l": null, "volume": "294", "issue": null, "pages": "114718"}, "abstract": "This paper explores news media discourse about COVID-19 during the spring of 2020 in Sweden, aiming to provide an understanding of how moralising discourse is employed in narratives about public health risks and responses. We investigate print news media content about the corona virus and COVID-19 during the early stages of the outbreak, guided analytically by framework focusing on the relationship between moral panics and moral regulation. We direct attention, first, to how both moral majorities and villains, i.e., 'folk devils', and heroes are constructed in the news. Secondly, we look at how visions for interventions are produced discursively in relation to such constructions. Our findings suggest that moralising discourse largely target risk behaviours and health care claims of middle-class groups. We also find that news media discourse about the pandemic in Sweden is marked by attacks on government interventions that are distinctly different from observations in other contexts. In conclusion, we discuss these observations in relation the political and discursive context, and the potential impact of moralising discourse on the legitimacy of public health interventions and the welfare state. Finally, we also discuss how our findings can inform theoretical discussions about political populism, moralising discourse and public health.", "doi": "10.1016/j.socscimed.2022.114718", "pmid": "35085897", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0277-9536(22)00021-1"}, {"db": "pmc", "key": "PMC8743484"}], "notes": [], "created": "2022-01-31T11:43:59.900Z", "modified": "2022-11-22T05:41:23.500Z"}, {"entity": "publication", "iuid": "2c389a8a7c8646bba44c12940f051816", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c389a8a7c8646bba44c12940f051816.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c389a8a7c8646bba44c12940f051816"}}, "title": "Effective Learning in Virtual Conferences: The Application of Five Principles of Learning.", "authors": [{"family": "Hofst\u00e4dter-Thalmann", "given": "Eva", "initials": "E"}, {"family": "Rotgans", "given": "Jerome I", "initials": "JI", "orcid": "0000-0003-4043-8261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28e7b128b0af4b228210644314f3cca2.json"}}, {"family": "Aybar Perez", "given": "Noelia", "initials": "N"}, {"family": "Nordquist", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2022-01-10", "journal": {"title": "J Eur CME", "issn": "2161-4083", "issn-l": null, "volume": "11", "issue": "1", "pages": "2019435"}, "abstract": "In this article, we examine the adaptation of learning among scientists and healthcare professionals in conferences and symposia from face-to-face to fully virtual meetings accelerated in the last years. Advantages and limitations for both settings have been described in different research studies but the effectiveness of learning can be reflected similarly by applying five fundamental principles of learning, which are based on empirical research in cognitive psychology. From a practical context, we compared the individual learning outcomes from two satellite symposia conducted face-to-face in 2019 and virtually in 2021 at the European Congress of Urology, EAU. Although both conference formats were almost identical, the five principles of learning were applied in both symposia. There were also some differences due to adaptation to online conferences, and our findings suggest that the virtual conference was perceived as significantly more effective than the face-to-face conference on all five criteria, and digital learning is a valid alternative to face-to-face conferences. What still needs to be better understood and analysed is the informal learning that is taking place during conferences, but suggesting an active design of any digital event by combining \"technical literacy\u00b7 with \"learning literacy\" will enable us to better analyse and study the impact of learning using the five learning principles in the design of other events in the future.", "doi": "10.1080/21614083.2021.2019435", "pmid": "35036048", "labels": {"Topics: Register-based research": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "2019435"}, {"db": "pmc", "key": "PMC8757606"}], "notes": [], "created": "2022-01-27T07:39:42.217Z", "modified": "2022-11-22T05:42:08.960Z"}, {"entity": "publication", "iuid": "4e9e8ed8fd3045c4b466ade89269d35e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4e9e8ed8fd3045c4b466ade89269d35e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4e9e8ed8fd3045c4b466ade89269d35e"}}, "title": "Characteristics and outcomes of COVID-19 patients with and without asthma from the United States, South Korea, and Europe.", "authors": [{"family": "Morales", "given": "Daniel", "initials": "D"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Lai", "given": "Lana", "initials": "L"}, {"family": "Sena", "given": "Anthony", "initials": "A"}, {"family": "Duvall", "given": "Scott", "initials": "S"}, {"family": "Suchard", "given": "Marc", "initials": "M"}, {"family": "Verhamme", "given": "Katia", "initials": "K", "orcid": "0000-0001-8162-4904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46ea3f9b89684f919ded6cda30a7170f.json"}}, {"family": "Rjinbeek", "given": "Peter", "initials": "P"}, {"family": "Posada", "given": "Joe", "initials": "J"}, {"family": "Ahmed", "given": "Waheed", "initials": "W"}, {"family": "Alshammary", "given": "Thamer", "initials": "T"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Blacketer", "given": "Clair", "initials": "C"}, {"family": "Burn", "given": "Ed", "initials": "E"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "You", "given": "Seng", "initials": "S"}, {"family": "Dawoud", "given": "Dalia", "initials": "D"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Gong", "given": "Menchung", "initials": "M"}, {"family": "Jonnagaddala", "given": "Jitendra", "initials": "J"}, {"family": "Lynch", "given": "Kristine", "initials": "K"}, {"family": "Matheny", "given": "Michael", "initials": "M"}, {"family": "Minty", "given": "Evan", "initials": "E"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Uribe", "given": "Albert", "initials": "A"}, {"family": "Recalde", "given": "Martina", "initials": "M"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Scheumie", "given": "Martijn", "initials": "M"}, {"family": "Shah", "given": "Karishma", "initials": "K"}, {"family": "Shah", "given": "Nigam", "initials": "N"}, {"family": "Schilling", "given": "Lisa", "initials": "L"}, {"family": "Vizcaya", "given": "David", "initials": "D"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Durate-Salles", "given": "Talita", "initials": "T"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}], "type": "journal article", "published": "2022-01-10", "journal": {"title": "J Asthma", "issn": "1532-4303", "pages": "1-14", "issn-l": null}, "abstract": "Objective: Large international comparisons describing the clinical characteristics of patients with COVID-19 are limited. The aim of the study was to perform a large-scale descriptive characterization of COVID-19 patients with asthma.Methods: We included nine databases contributing data from January-June 2020 from the US, South Korea (KR), Spain, UK and the Netherlands. We defined two cohorts of COVID-19 patients ('diagnosed' and 'hospitalized') based on COVID-19 disease codes. We followed patients from COVID-19 index date to 30 days or death. We performed descriptive analysis and reported the frequency of characteristics and outcomes in people with asthma defined by codes and prescriptions.Results: The diagnosed and hospitalized cohorts contained 666,933 and 159,552 COVID-19 patients respectively. Exacerbation in people with asthma was recorded in 1.6%-8.6% of patients at presentation. Asthma prevalence ranged from 6.2% (95%CI 5.7-6.8) to 18.5% (95%CI 18.2-18.8) in the diagnosed cohort and 5.2% (95%CI 4.0-6.8) to 20.5% (95%CI 18.6-22.6) in the hospitalized cohort. Asthma patients with COVID-19 had high prevalence of comorbidity including hypertension, heart disease, diabetes and obesity. Mortality ranged from 2.1% (95%CI 1.8-2.4) to 16.9% (95%CI 13.8-20.5) and similar or lower compared to COVID-19 patients without asthma. Acute respiratory distress syndrome occurred in 15%-30% of hospitalized COVID-19 asthma patients.Conclusion: The prevalence of asthma among COVID-19 patients varies internationally. Asthma patients with COVID-19 have high comorbidity. The prevalence of asthma exacerbation at presentation was low. Whilst mortality was similar among COVID-19 patients with and without asthma, this could be confounded by differences in clinical characteristics. Further research could help identify high-risk asthma patients.", "doi": "10.1080/02770903.2021.2025392", "pmid": "35012410", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-13T21:06:24.354Z", "modified": "2022-01-13T21:06:34.436Z"}, {"entity": "publication", "iuid": "1d45408f77254505981cbcae69859833", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d45408f77254505981cbcae69859833.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d45408f77254505981cbcae69859833"}}, "title": "COVID-19 pandemic impact on cytopathology practice in the post-lockdown period: An international, multicenter study.", "authors": [{"family": "Vigliar", "given": "Elena", "initials": "E"}, {"family": "Pisapia", "given": "Pasquale", "initials": "P", "orcid": "0000-0002-6429-0620", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/852012229c1845389cd2edf7be3bc629.json"}}, {"family": "Dello Iacovo", "given": "Filippo", "initials": "F"}, {"family": "Alcaraz-Mateos", "given": "Eduardo", "initials": "E"}, {"family": "Al\u00ec", "given": "Greta", "initials": "G"}, {"family": "Ali", "given": "Syed Z", "initials": "SZ"}, {"family": "Baloch", "given": "Zubair W", "initials": "ZW"}, {"family": "Bellevicine", "given": "Claudio", "initials": "C", "orcid": "0000-0002-7479-6457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d949e1ed72c2460a8063ee8be1bc5943.json"}}, {"family": "Bongiovanni", "given": "Massimo", "initials": "M", "orcid": "0000-0001-9846-6682", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84e33246c3844d6cb5682085e59a8401.json"}}, {"family": "Botsun", "given": "Pavlina", "initials": "P"}, {"family": "Bruzzese", "given": "Dario", "initials": "D"}, {"family": "Bubendorf", "given": "Lukas", "initials": "L", "orcid": "0000-0001-5970-1803", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00e786919dfd4d7a9ad0c5fcb93e1f10.json"}}, {"family": "B\u00fcttner", "given": "Reinhard", "initials": "R"}, {"family": "Canberk", "given": "Sule", "initials": "S", "orcid": "0000-0002-3736-1323", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26dc73d74c604ce3bab1ca1f7c55561b.json"}}, {"family": "Capitanio", "given": "Arrigo", "initials": "A"}, {"family": "Casadio", "given": "Chiara", "initials": "C"}, {"family": "Cazacu", "given": "Eugeniu", "initials": "E"}, {"family": "Cochand-Priollet", "given": "Beatrix", "initials": "B"}, {"family": "D'Amuri", "given": "Alessandro", "initials": "A"}, {"family": "Davis", "given": "Katelynn", "initials": "K"}, {"family": "Eloy", "given": "Catarina", "initials": "C", "orcid": "0000-0001-7642-1280", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf436dea894e4c7fa1c499b83d218f39.json"}}, {"family": "Engels", "given": "Marianne", "initials": "M"}, {"family": "Fadda", "given": "Guido", "initials": "G"}, {"family": "Fontanini", "given": "Gabriella", "initials": "G"}, {"family": "Fulciniti", "given": "Franco", "initials": "F"}, {"family": "Hofman", "given": "Paul", "initials": "P", "orcid": "0000-0003-0431-9353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80753da68c474a46a5fd85c76e468fdb.json"}}, {"family": "Iaccarino", "given": "Antonino", "initials": "A"}, {"family": "Ieni", "given": "Antonio", "initials": "A"}, {"family": "Jiang", "given": "Xiaoyin Sara", "initials": "XS", "orcid": "0000-0002-3069-3130", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5826f5fd5af4a84ac308e9368fbcad9.json"}}, {"family": "Kakudo", "given": "Kennichi", "initials": "K", "orcid": "0000-0002-0347-7264", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2cbc47cb73124e98ac7d540b562f0b97.json"}}, {"family": "Kern", "given": "Izidor", "initials": "I"}, {"family": "Kholova", "given": "Ivana", "initials": "I"}, {"family": "Linton McDermott", "given": "Kathryn M", "initials": "KM"}, {"family": "Liu", "given": "Chinhua", "initials": "C"}, {"family": "Lobo", "given": "Anandi", "initials": "A"}, {"family": "Lozano", "given": "Maria D", "initials": "MD", "orcid": "0000-0002-6796-9380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54800a1ac917410c9cfa7ab5f3b22bc2.json"}}, {"family": "Malapelle", "given": "Umberto", "initials": "U"}, {"family": "Maleki", "given": "Zahra", "initials": "Z", "orcid": "0000-0003-3273-4802", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31b3a0890ae1476abfa8eb1bfd8df3ee.json"}}, {"family": "Michelow", "given": "Pamela", "initials": "P"}, {"family": "Mikula", "given": "Michael W", "initials": "MW"}, {"family": "Musayev", "given": "Jamal", "initials": "J"}, {"family": "\u00d6zg\u00fcn", "given": "Gonca", "initials": "G"}, {"family": "Oznur", "given": "Meltem", "initials": "M"}, {"family": "Peir\u00f3 Marqu\u00e9s", "given": "Francisca Maria", "initials": "FM"}, {"family": "Poller", "given": "David", "initials": "D"}, {"family": "Pyzlak", "given": "Michal", "initials": "M"}, {"family": "Robinson", "given": "Betsy", "initials": "B"}, {"family": "Rossi", "given": "Esther Diana", "initials": "ED", "orcid": "0000-0003-3819-4229", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/353c4e390a6646f0a52cd11d0ec6aeb7.json"}}, {"family": "Roy-Chowdhuri", "given": "Sinchita", "initials": "S", "orcid": "0000-0002-9447-7701", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ca8b8486db4f45eebd213b3d4770fa0f.json"}}, {"family": "Saieg", "given": "Mauro", "initials": "M", "orcid": "0000-0002-9438-226X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/921ab9772dbb44e69e06da15d306ca48.json"}}, {"family": "Savic Prince", "given": "Spasenija", "initials": "S"}, {"family": "Schmitt", "given": "Fernando C", "initials": "FC"}, {"family": "Segu\u00ed Iv\u00e1\u00f1ez", "given": "Francisco Javier", "initials": "FJ"}, {"family": "\u0160toos-Vei\u0107", "given": "Tajana", "initials": "T"}, {"family": "Sulaieva", "given": "Oksana", "initials": "O"}, {"family": "Sweeney", "given": "Brenda J", "initials": "BJ"}, {"family": "Tuccari", "given": "Giovanni", "initials": "G"}, {"family": "van Velthuysen", "given": "Marie-Louise", "initials": "ML"}, {"family": "VanderLaan", "given": "Paul A", "initials": "PA", "orcid": "0000-0002-7234-5652", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d17424496a6b41efbc5d6fba770344a8.json"}}, {"family": "Vielh", "given": "Philippe", "initials": "P"}, {"family": "Viola", "given": "Patrizia", "initials": "P"}, {"family": "Voorham", "given": "Quirinus J M", "initials": "QJM"}, {"family": "Weynand", "given": "Birgit", "initials": "B"}, {"family": "Zeppa", "given": "Pio", "initials": "P", "orcid": "0000-0001-7358-5925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9687953aaff245c8aa33b11d17655cbf.json"}}, {"family": "Faquin", "given": "William C", "initials": "WC", "orcid": "0000-0002-9043-7171", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf42ad6f77864413a0a1d273f6a6c977.json"}}, {"family": "Pitman", "given": "Martha Bishop", "initials": "MB"}, {"family": "Troncone", "given": "Giancarlo", "initials": "G", "orcid": "0000-0003-1630-5805", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a12ba1f7a12141b6b95e6e715b12e9db.json"}}], "type": "journal article", "published": "2022-01-10", "journal": {"title": "Cancer Cytopathol", "issn": "1934-6638", "issn-l": null}, "abstract": "In a previous worldwide survey, the authors showed a drastic reduction in the number of cytological specimens processed during the coronavirus disease 2019 \"lockdown\" period along with an increase in malignancy rates. To assess the continued impact of the pandemic on cytological practices around the world, they undertook a second follow-up worldwide survey collecting data from the post-lockdown period (2020).\n\nParticipants were asked to provide data regarding their cytopathology activity during the first 12 weeks of their respective national post-lockdown period (2020), which ranged from April 4 to October 31. Differences between the post-lockdown period and the corresponding 2019 period were evaluated, and the authors specifically focused on rates of malignant diagnoses.\n\nA total of 29 respondents from 17 countries worldwide joined the survey. Overall, a lower number of cytological specimens (n = 236,352) were processed in comparison with the same period in 2019 (n = 321,466) for a relative reduction of 26.5%. The overall malignancy rate showed a statistically significant increase (12,442 [5.26%] vs 12,882 [4.01%]; P < .001) during the same time period. Similar results were obtained if both malignancy and suspicious for malignancy rates were considered together (15,759 [6.58%] vs 16,011 [4.98%]; P < .001).\n\nThe data showed a persistent reduction in the cytological specimen volume during the post-lockdown period (2020). However, the relative increase in the cytological workload in the late part of the post-lockdown is a promising finding of a slow return to normality.", "doi": "10.1002/cncy.22547", "pmid": "35006650", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-13T21:09:27.944Z", "modified": "2022-01-13T21:09:28.530Z"}, {"entity": "publication", "iuid": "0e7c6e43fa9549238ec093d52cb77749", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e7c6e43fa9549238ec093d52cb77749.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e7c6e43fa9549238ec093d52cb77749"}}, "title": "A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo.", "authors": [{"family": "Hanke", "given": "Leo", "initials": "L", "orcid": "0000-0001-5514-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a35f10de4f2e4aee98278f6ab845613d.json"}}, {"family": "Das", "given": "Hrishikesh", "initials": "H", "orcid": "0000-0001-7495-7065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/496d4befba454f3f85e23ddd413ada9c.json"}}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Perez Vidakovics", "given": "Laura", "initials": "L", "orcid": "0000-0003-4283-812X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b85cf54481e94b8c95f2bf8db1038395.json"}}, {"family": "Urgard", "given": "Egon", "initials": "E"}, {"family": "Moliner-Morro", "given": "Ainhoa", "initials": "A"}, {"family": "Kim", "given": "Changil", "initials": "C", "orcid": "0000-0003-4977-4384", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d36347170c34ca386deee72faccc534.json"}}, {"family": "Karl", "given": "Vivien", "initials": "V"}, {"family": "Pankow", "given": "Alec", "initials": "A"}, {"family": "Smith", "given": "Natalie L", "initials": "NL"}, {"family": "Porebski", "given": "Bartlomiej", "initials": "B"}, {"family": "Fernandez-Capetillo", "given": "Oscar", "initials": "O"}, {"family": "Sezgin", "given": "Erdinc", "initials": "E", "orcid": "0000-0002-4915-388X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30c3688527ac4caf8d07426703ace615.json"}}, {"family": "Pedersen", "given": "Gabriel K", "initials": "GK"}, {"family": "Coquet", "given": "Jonathan M", "initials": "JM", "orcid": "0000-0002-5967-4857", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ca3e4664dc444a3a992531ad3dd9201.json"}}, {"family": "H\u00e4llberg", "given": "B Martin", "initials": "BM", "orcid": "0000-0002-6781-0345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea241fd233ca40a6be4ffa1472d2aa06.json"}}, {"family": "Murrell", "given": "Ben", "initials": "B", "orcid": "0000-0002-0393-4445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60dac9ecf84d4eb3b90fb4ee1298bc52.json"}}, {"family": "McInerney", "given": "Gerald M", "initials": "GM", "orcid": "0000-0003-2257-7241", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7770437d845444a8a07865bf5b62fab0.json"}}], "type": "journal article", "published": "2022-01-10", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "13", "issue": "1", "pages": "155"}, "abstract": "Antibodies binding to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike have therapeutic promise, but emerging variants show the potential for virus escape. This emphasizes the need for therapeutic molecules with distinct and novel neutralization mechanisms. Here we describe the isolation of a nanobody that interacts simultaneously with two RBDs from different spike trimers of SARS-CoV-2, rapidly inducing the formation of spike trimer-dimers leading to the loss of their ability to attach to the host cell receptor, ACE2. We show that this nanobody potently neutralizes SARS-CoV-2, including the beta and delta variants, and cross-neutralizes SARS-CoV. Furthermore, we demonstrate the therapeutic potential of the nanobody against SARS-CoV-2 and the beta variant in a human ACE2 transgenic mouse model. This naturally elicited bispecific monomeric nanobody establishes an uncommon strategy for potent inactivation of viral antigens and represents a promising antiviral against emerging SARS-CoV-2 variants.", "doi": "10.1038/s41467-021-27610-z", "pmid": "35013189", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Funder: H2020": null, "Research Area: Drug discovery and repurposing of drugs": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC8748511"}, {"db": "URL", "key": "https://www.ebi.ac.uk/emdb/EMD-12465", "description": "https://www.ebi.ac.uk/emdb/EMD-12465"}, {"db": "URL", "key": "https://www.ebi.ac.uk/emdb/EMD-12461", "description": "https://www.ebi.ac.uk/emdb/EMD-12461"}], "notes": [], "created": "2022-01-11T06:56:36.794Z", "modified": "2022-02-17T08:51:26.108Z"}, {"entity": "publication", "iuid": "4f962a14f58b4d73ae2463bc11156c41", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4f962a14f58b4d73ae2463bc11156c41.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4f962a14f58b4d73ae2463bc11156c41"}}, "title": "Premature mortality attributable to COVID-19: potential years of life lost in 17 countries around the world, January-August 2020.", "authors": [{"family": "Ugarte", "given": "Maider Pagola", "initials": "MP"}, {"family": "Achilleos", "given": "Souzana", "initials": "S", "orcid": "0000-0002-1688-9225", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce5b51f054484805abea56ebad2bffc6.json"}}, {"family": "Quattrocchi", "given": "Annalisa", "initials": "A"}, {"family": "Gabel", "given": "John", "initials": "J"}, {"family": "Kolokotroni", "given": "Ourania", "initials": "O"}, {"family": "Constantinou", "given": "Constantina", "initials": "C"}, {"family": "Nicolaou", "given": "Nicoletta", "initials": "N"}, {"family": "Rodriguez-Llanes", "given": "Jose Manuel", "initials": "JM"}, {"family": "Huang", "given": "Qian", "initials": "Q"}, {"family": "Verstiuk", "given": "Olesia", "initials": "O"}, {"family": "Pidmurniak", "given": "Nataliia", "initials": "N"}, {"family": "Tao", "given": "Jennifer Wenjing", "initials": "JW"}, {"family": "Burstr\u00f6m", "given": "Bo", "initials": "B"}, {"family": "Klepac", "given": "Petra", "initials": "P"}, {"family": "Erzen", "given": "Ivan", "initials": "I"}, {"family": "Chong", "given": "Mario", "initials": "M"}, {"family": "Barron", "given": "Manuel", "initials": "M"}, {"family": "Hagen", "given": "Terje P", "initials": "TP"}, {"family": "Kalmatayeva", "given": "Zhanna", "initials": "Z"}, {"family": "Davletov", "given": "Kairat", "initials": "K"}, {"family": "Zucker", "given": "Inbar", "initials": "I"}, {"family": "Kaufman", "given": "Zalman", "initials": "Z"}, {"family": "Kereselidze", "given": "Maia", "initials": "M"}, {"family": "Kandelaki", "given": "Levan", "initials": "L"}, {"family": "Le Meur", "given": "Nolwenn", "initials": "N"}, {"family": "Goldsmith", "given": "Lucy", "initials": "L"}, {"family": "Critchley", "given": "Julia A", "initials": "JA"}, {"family": "Pinilla", "given": "Maria Angelica", "initials": "MA"}, {"family": "Jaramillo", "given": "Gloria Isabel", "initials": "GI"}, {"family": "Teixeira", "given": "Domingos", "initials": "D"}, {"family": "Gom\u00e9z", "given": "Lara Ferrero", "initials": "LF"}, {"family": "Lobato", "given": "Jackeline", "initials": "J"}, {"family": "Ara\u00fajo", "given": "Carolina", "initials": "C"}, {"family": "Cuthbertson", "given": "Joseph", "initials": "J"}, {"family": "Bennett", "given": "Catherine M", "initials": "CM"}, {"family": "Polemitis", "given": "Antonis", "initials": "A"}, {"family": "Charalambous", "given": "Andreas", "initials": "A"}, {"family": "Demetriou", "given": "Christiana A", "initials": "CA"}, {"family": "C-MOR consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2022-01-09", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "22", "issue": "1", "pages": "54", "issn-l": null}, "abstract": "Understanding the impact of the burden of COVID-19 is key to successfully navigating the COVID-19 pandemic. As part of a larger investigation on COVID-19 mortality impact, this study aims to estimate the Potential Years of Life Lost (PYLL) in 17 countries and territories across the world (Australia, Brazil, Cape Verde, Colombia, Cyprus, France, Georgia, Israel, Kazakhstan, Peru, Norway, England & Wales, Scotland, Slovenia, Sweden, Ukraine, and the United States [USA]).\n\nAge- and sex-specific COVID-19 death numbers from primary national sources were collected by an international research consortium. The study period was established based on the availability of data from the inception of the pandemic to the end of August 2020. The PYLL for each country were computed using 80 years as the maximum life expectancy.\n\nAs of August 2020, 442,677 (range: 18-185,083) deaths attributed to COVID-19 were recorded in 17 countries which translated to 4,210,654 (range: 112-1,554,225) PYLL. The average PYLL per death was 8.7 years, with substantial variation ranging from 2.7 years in Australia to 19.3 PYLL in Ukraine. North and South American countries as well as England & Wales, Scotland and Sweden experienced the highest PYLL per 100,000 population; whereas Australia, Slovenia and Georgia experienced the lowest. Overall, males experienced higher PYLL rate and higher PYLL per death than females. In most countries, most of the PYLL were observed for people aged over 60 or 65 years, irrespective of sex. Yet, Brazil, Cape Verde, Colombia, Israel, Peru, Scotland, Ukraine, and the USA concentrated most PYLL in younger age groups.\n\nOur results highlight the role of PYLL as a tool to understand the impact of COVID-19 on demographic groups within and across countries, guiding preventive measures to protect these groups under the ongoing pandemic. Continuous monitoring of PYLL is therefore needed to better understand the burden of COVID-19 in terms of premature mortality.", "doi": "10.1186/s12889-021-12377-1", "pmid": "35000578", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-12377-1"}], "notes": [], "created": "2022-01-13T21:12:19.822Z", "modified": "2022-01-13T21:12:19.852Z"}, {"entity": "publication", "iuid": "5a5acc90669347b880b44b80f950c5b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5a5acc90669347b880b44b80f950c5b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5a5acc90669347b880b44b80f950c5b3"}}, "title": "Occupation and COVID-19 diagnosis, hospitalisation and ICU admission among foreign-born and Swedish-born employees: a register-based study.", "authors": [{"family": "Nwaru", "given": "Chioma Adanma", "initials": "CA", "orcid": "0000-0002-1772-2347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/901880ae4f9143cc96fedf11aa673bc7.json"}}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Franz\u00e9n", "given": "Stefan", "initials": "S"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}], "type": "journal article", "published": "2022-01-07", "journal": {"title": "J Epidemiol Community Health", "issn": "1470-2738", "issn-l": null}, "abstract": "Research on occupation and risk of COVID-19 among foreign-born workers is lacking. We investigated whether working in essential occupations was associated with COVID-19 diagnosis, hospitalisation and intensive care unit (ICU) admission and whether foreign-born workers in similar occupations as Swedish-born individuals had a higher risk of the studied outcomes.\n\nOccupational data (2018-2019) of 326 052 employees (20-65 years) who were resident in Sweden as of 1 January 2020 were linked to COVID-19 data registered from 1 January 2020 to 28 February 2021. We analysed the risk of COVID-19 outcomes in different occupational groups and in four immigrant/occupation intersectional groups using Cox proportional hazards regression with adjustments for sociodemographic and socioeconomic characteristics and pre-existing comorbidities.\n\nWe identified 29797, 1069 and 152 cases of COVID-19 diagnosis, hospitalisations and ICU admissions, respectively, in our cohort. Workers in essential occupations had an elevated risk of COVID-19 diagnosis, hospitalisation, and ICU admissions. Healthcare workers had a higher risk of all the outcomes compared with other essential workers. Relative to Swedish-born workers in non-essential occupations, foreign-born workers in essential occupations had 1.85 (95% CI 1.78 to 1.93), 3.80 (95% CI 3.17 to 4.55) and 3.79 (95% CI 2.33 to 6.14) times higher risk of COVID-19 diagnosis, hospitalisation and ICU admission, respectively. The corresponding risks among Swedish-born workers in essential occupations were 1.44 (95% CI 1.40 to 1.49), 1.30 (95% CI 1.08 to 1.56) and 1.46 (95% CI 0.90 to 2.38).\n\nOccupation was associated with COVID-19 outcomes and contributed to the burden of COVID-19 among foreign-born individuals in this study.", "doi": "10.1136/jech-2021-218278", "pmid": "34996808", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "jech-2021-218278"}], "notes": [], "created": "2022-01-10T15:29:08.356Z", "modified": "2022-01-10T15:29:08.430Z"}, {"entity": "publication", "iuid": "52e1e554737e44d5996fffab9096eb18", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/52e1e554737e44d5996fffab9096eb18.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/52e1e554737e44d5996fffab9096eb18"}}, "title": "Immunity to SARS-CoV-2 up to 15 months after infection.", "authors": [{"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Piralla", "given": "Antonio", "initials": "A"}, {"family": "Zuo", "given": "Fanglei", "initials": "F"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Cassaniti", "given": "Irene", "initials": "I"}, {"family": "Wan", "given": "Hui", "initials": "H"}, {"family": "Kumagai-Braesh", "given": "Makiko", "initials": "M"}, {"family": "Andr\u00e9ll", "given": "Juni", "initials": "J"}, {"family": "Percivalle", "given": "Elena", "initials": "E"}, {"family": "Sammartino", "given": "Jos\u00e8 Camilla", "initials": "JC"}, {"family": "Wang", "given": "Yating", "initials": "Y"}, {"family": "Vlachiotis", "given": "Stelios", "initials": "S"}, {"family": "Attevall", "given": "Janine", "initials": "J"}, {"family": "Bergami", "given": "Federica", "initials": "F"}, {"family": "Ferrari", "given": "Alessandro", "initials": "A"}, {"family": "Colaneri", "given": "Marta", "initials": "M"}, {"family": "Vecchia", "given": "Marco", "initials": "M"}, {"family": "Sambo", "given": "Margherita", "initials": "M"}, {"family": "Zuccaro", "given": "Valentina", "initials": "V"}, {"family": "Asperges", "given": "Erika", "initials": "E"}, {"family": "Bruno", "given": "Raffaele", "initials": "R"}, {"family": "Oggionni", "given": "Tiberio", "initials": "T"}, {"family": "Meloni", "given": "Federica", "initials": "F"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Bertoglio", "given": "Federico", "initials": "F"}, {"family": "Schubert", "given": "Maren", "initials": "M"}, {"family": "Calzolai", "given": "Luigi", "initials": "L"}, {"family": "Varani", "given": "Luca", "initials": "L"}, {"family": "Hust", "given": "Michael", "initials": "M"}, {"family": "Xue", "given": "Yintong", "initials": "Y"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}], "type": "journal article", "published": "2022-01-07", "journal": {"title": "iScience", "issn": "2589-0042", "pages": "103743", "issn-l": "2589-0042"}, "abstract": "Information concerning the longevity of immunity to SARS-CoV-2 following natural infection may have considerable implications for durability of immunity induced by vaccines. Here, we monitored the SARS-CoV-2 specific immune response in COVID-19 patients followed up to 15 months after symptoms onset. Following a peak at day 15-28 post-infection, the IgG antibody response and plasma neutralizing titers gradually decreased over time but stabilized after 6 months. Compared to G614, plasma neutralizing titers were more than 8-fold lower against variants Beta, Gamma and Delta. SARS-CoV-2-specific memory B and T cells persisted in the majority of patients up to 15 months although a significant decrease in specific T cells, but not B cells, was observed between 6 and 15 months. The antiviral specific immunity especially memory B cells in COVID-19 convalescent patients is long-lasting, but some variants of concern may at least partially escape the neutralizing activity of plasma antibodies.", "doi": "10.1016/j.isci.2022.103743", "pmid": "35018336", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(22)00013-X"}, {"db": "pmc", "key": "PMC8736281"}], "notes": [], "created": "2022-01-13T20:59:32.521Z", "modified": "2022-01-13T20:59:32.535Z"}, {"entity": "publication", "iuid": "2fa81706e5ad425182dc27b9e57922ac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2fa81706e5ad425182dc27b9e57922ac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2fa81706e5ad425182dc27b9e57922ac"}}, "title": "COVID-19 related outcomes among individuals with neurodegenerative diseases: a cohort analysis in the UK biobank.", "authors": [{"family": "Hu", "given": "Yihan", "initials": "Y"}, {"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Hou", "given": "Can", "initials": "C"}, {"family": "Chen", "given": "Wenwen", "initials": "W"}, {"family": "Zhang", "given": "Hanyue", "initials": "H"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Sun", "given": "Yajing", "initials": "Y"}, {"family": "Qu", "given": "Yuanyuan", "initials": "Y"}, {"family": "Feychting", "given": "Maria", "initials": "M"}, {"family": "Valdimarsdottir", "given": "Unnur", "initials": "U"}, {"family": "Song", "given": "Huan", "initials": "H", "orcid": "0000-0003-3845-8079", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2e35902226b407487330fc6c7368759.json"}}, {"family": "Fang", "given": "Fang", "initials": "F"}], "type": "journal article", "published": "2022-01-07", "journal": {"title": "BMC Neurol", "issn": "1471-2377", "volume": "22", "issue": "1", "pages": "15", "issn-l": null}, "abstract": "An increased susceptibility to COVID-19 has been suggested for individuals with neurodegenerative diseases, but data are scarce from longitudinal studies.\n\nIn this community-based cohort study, we included 96,275 participants of the UK Biobank who had available SARS-CoV-2 test results in Public Health England. Of these, 2617 had a clinical diagnosis of neurodegenerative diseases in the UK Biobank inpatient hospital data before the outbreak of COVID-19 (defined as January 31st, 2020), while the remaining participants constituted the reference group. We then followed both groups from January 31st, 2020 to June 14th, 2021 for ascertainment of COVID-19 outcomes, including any COVID-19, inpatient care for COVID-19, and COVID-19 related death. Logistic regression was applied to estimate the association between neurogenerative disease and risks of COVID-19 outcomes, adjusted for multiple confounders and somatic comorbidities.\n\nWe observed an elevated risk of COVID-19 outcomes among individuals with a neurodegenerative disease compared with the reference group, corresponding to a fully adjusted odds ratio of 2.47 (95%CI 2.25-2.71) for any COVID-19, 2.18 (95%CI 1.94-2.45) for inpatient COVID-19, and 3.67 (95%CI 3.11-4.34) for COVID-19 related death. Among individuals with a positive test result for SARS-CoV-2, individuals with neurodegenerative diseases had also a higher risk of COVID-19 related death than others (fully adjusted odds ratio 2.08; 95%CI 1.71-2.53).\n\nAmong UK Biobank participants who received at least one test for SARS-CoV-2, a pre-existing diagnosis of neurodegenerative disease was associated with a subsequently increased risk of COVID-19, especially COVID-19 related death.", "doi": "10.1186/s12883-021-02536-7", "pmid": "34996388", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8739517"}, {"db": "pii", "key": "10.1186/s12883-021-02536-7"}], "notes": [], "created": "2022-01-10T15:30:44.904Z", "modified": "2023-06-19T14:48:12.016Z"}, {"entity": "publication", "iuid": "57157113a28045798857617d872a36db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/57157113a28045798857617d872a36db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/57157113a28045798857617d872a36db"}}, "title": "COVID-19 collateral damage-psychological burden and behavioural changes among older adults during the first outbreak in Stockholm, Sweden: a cross-sectional study.", "authors": [{"family": "Beridze", "given": "Giorgi", "initials": "G", "orcid": "0000-0002-2615-226X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0a1b88868e743d180580c5545dc3b3f.json"}}, {"family": "Triolo", "given": "Federico", "initials": "F"}, {"family": "Grande", "given": "Giulia", "initials": "G"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A", "orcid": "0000-0001-9064-9222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/166407b0da5346b3aef841949b0212da.json"}}], "type": "journal article", "published": "2022-01-07", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "1", "pages": "e058422", "issn-l": "2044-6055"}, "abstract": "To explore the indirect negative effects of COVID-19 restrictions (collateral damage) on the lives and health of older adults living in central Stockholm, and to characterise the sociodemographic profile of those with the highest susceptibility to this damage.\n\nCross-sectional study.\n\nDistrict of Kungsholmen in Stockholm, Sweden.\n\nOlder adults aged 68 years and above (n=1231) who participated in the ad hoc COVID-19-related phone questionnaire administered by trained staff between May and June 2020 and who had previously attended the regular follow-up assessment of the Swedish National study on Aging and Care in Kungsholmen (SNAC-K) during 2016-2019.\n\nThree dimensions of collateral damage: psychological burden (feelings of worry, stress and loneliness), reductions in social and physical activities, and reductions in medical and social care use since the beginning of the pandemic. Logistic regression models were used to test the association between age, sex, education and living arrangement, and the risk of collateral damage.\n\nVast majority of participants adhered to the national public health recommendations, with over three-quarters practising self-isolation (n=928). Half of the sample reported psychological burden, 55.3% reported reductions in social or physical activity, and 11.3% reported decreased medical or social care use. Over three quarters of participants (77.8%) were affected by at least one of the three collateral damage dimensions. Female sex was the strongest sociodemographic predictor of both individual and co-occurring dimensions of collateral damage.\n\nCOVID-19 and its restrictions during the first half of 2020 had a negative effect on the health and lives of a majority of the elderly living in central Stockholm. Women were at a higher risk of these negative consequences. We emphasise the need for predefined, evidence-based interventions to support those who are most susceptible to these consequences, both during the pandemic and once the outbreak is overcome.", "doi": "10.1136/bmjopen-2021-058422", "pmid": "34996805", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-058422"}], "notes": [], "created": "2022-01-10T15:29:48.426Z", "modified": "2022-01-10T15:29:48.506Z"}, {"entity": "publication", "iuid": "11d995e1fa8945db86dd93e86bc0fe4a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/11d995e1fa8945db86dd93e86bc0fe4a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/11d995e1fa8945db86dd93e86bc0fe4a"}}, "title": "What Do Physicians Think About the Use of Telemedicine to Recruit and Assess Participants in mHealth-Related Clinical Studies as a Consequence of the COVID-19 Pandemic?", "authors": [{"family": "Pereira", "given": "Ana Margarida", "initials": "AM", "orcid": "0000-0002-5468-0932", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8bb795e913654a9d80a82086f074f65c.json"}}, {"family": "Almeida", "given": "Rute", "initials": "R"}, {"family": "Amaral", "given": "Rita", "initials": "R"}, {"family": "Alves-Correia", "given": "Magna", "initials": "M"}, {"family": "Mendes", "given": "Sandra", "initials": "S"}, {"family": "Fonseca", "given": "Jo\u00e3o Almeida", "initials": "JA"}, {"family": "J\u00e1come", "given": "Cristina", "initials": "C"}], "type": "journal article", "published": "2022-01-06", "journal": {"title": "Telemed J E Health", "issn": "1556-3669", "issn-l": null}, "abstract": "Objectives:To evaluate physician's opinion and availability to participate in mHealth-related clinical studies with patient recruitment and assessment via telemedicine and to identify characteristics associated with the willingness to participate. Methods:Cross-sectional, observational study, based on an anonymous web survey conducted in May-Jun of 2020 to 237 physicians, from Portugal and Spain that collaborated with an asthma mHealth project (INSPIRERS). Results:Response rate was 51% (n = 120). Most (74%, n = 89) physicians were available to participate in such studies, but 62% anticipated lower recruiting capacity and 40% increased difficulty in obtaining quality data. Physicians aged \u226440 years, from secondary care (vs. general practitioners) and that used apps in personal life or clinical practice were more likely to be available. Conclusions:Three-quarters of the physicians were available to participate in mHealth-related clinical studies with patient recruitment and assessment through telemedicine. Age group, medical specialty, and app use were associated with the willingness to participate.", "doi": "10.1089/tmj.2021.0462", "pmid": "34990295", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-01-10T15:33:44.220Z", "modified": "2022-01-10T15:33:44.300Z"}, {"entity": "publication", "iuid": "901e928acfc04a9bab8320ab02f54b3e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/901e928acfc04a9bab8320ab02f54b3e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/901e928acfc04a9bab8320ab02f54b3e"}}, "title": "The Views and Needs of People With Parkinson Disease Regarding Wearable Devices for Disease Monitoring: Mixed Methods Exploration.", "authors": [{"family": "Kenny", "given": "Lorna", "initials": "L", "orcid": "0000-0002-5351-3091", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c99b991bb46f40c48d2bd92e392a431d.json"}}, {"family": "Moore", "given": "Kevin", "initials": "K", "orcid": "0000-0003-0712-2222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26393cb529d64dd4b4c4250b2af2cfce.json"}}, {"family": "O' Riordan", "given": "Cl\u00edona", "initials": "C", "orcid": "0000-0002-0509-3141", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eac991a073e040dcad6217fd9a272cc4.json"}}, {"family": "Fox", "given": "Siobhan", "initials": "S", "orcid": "0000-0002-6854-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a51699627a4f48efa9149b4e3642da49.json"}}, {"family": "Barton", "given": "John", "initials": "J", "orcid": "0000-0002-0671-5678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8c553326196499e8e842ea2cc53932f.json"}}, {"family": "Tedesco", "given": "Salvatore", "initials": "S", "orcid": "0000-0002-7752-2240", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0356fa19135145ad82e2a0738f0391b7.json"}}, {"family": "Sica", "given": "Marco", "initials": "M", "orcid": "0000-0003-4188-4482", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b03fc2e7f34843229b1ca469c08959b5.json"}}, {"family": "Crowe", "given": "Colum", "initials": "C", "orcid": "0000-0002-7479-9922", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb5c7f1c8b754c9b8ecde7025b1e9bc7.json"}}, {"family": "Alam\u00e4ki", "given": "Antti", "initials": "A", "orcid": "0000-0001-6293-6232", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b7b4de949974b03ac1a20387ec77ec8.json"}}, {"family": "Condell", "given": "Joan", "initials": "J", "orcid": "0000-0002-3517-2182", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56fb9f68e28547a6a93e5786726f41d7.json"}}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A", "orcid": "0000-0003-3534-456X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26229455bc3d42f6aea6b541c4d74b48.json"}}, {"family": "Timmons", "given": "Suzanne", "initials": "S", "orcid": "0000-0001-7790-9552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9bb14fd40cfb49799dd29451e885d14b.json"}}], "type": "journal article", "published": "2022-01-06", "journal": {"title": "JMIR Form Res", "issn": "2561-326X", "volume": "6", "issue": "1", "pages": "e27418", "issn-l": null}, "abstract": "Wearable devices can diagnose, monitor, and manage neurological disorders such as Parkinson disease. With a growing number of wearable devices, it is no longer a case of whether a wearable device can measure Parkinson disease motor symptoms, but rather which features suit the user. Concurrent with continued device development, it is important to generate insights on the nuanced needs of the user in the modern era of wearable device capabilities.\n\nThis study aims to understand the views and needs of people with Parkinson disease regarding wearable devices for disease monitoring and management.\n\nThis study used a mixed method parallel design, wherein survey and focus groups were concurrently conducted with people living with Parkinson disease in Munster, Ireland. Surveys and focus group schedules were developed with input from people with Parkinson disease. The survey included questions about technology use, wearable device knowledge, and Likert items about potential device features and capabilities. The focus group participants were purposively sampled for variation in age (all were aged >50 years) and sex. The discussions concerned user priorities, perceived benefits of wearable devices, and preferred features. Simple descriptive statistics represented the survey data. The focus groups analyzed common themes using a qualitative thematic approach. The survey and focus group analyses occurred separately, and results were evaluated using a narrative approach.\n\nOverall, 32 surveys were completed by individuals with Parkinson disease. Four semistructured focus groups were held with 24 people with Parkinson disease. Overall, the participants were positive about wearable devices and their perceived benefits in the management of symptoms, especially those of motor dexterity. Wearable devices should demonstrate clinical usefulness and be user-friendly and comfortable. Participants tended to see wearable devices mainly in providing data for health care professionals rather than providing feedback for themselves, although this was also important. Barriers to use included poor hand function, average technology confidence, and potential costs. It was felt that wearable device design that considered the user would ensure better compliance and adoption.\n\nWearable devices that allow remote monitoring and assessment could improve health care access for patients living remotely or are unable to travel. COVID-19 has increased the use of remotely delivered health care; therefore, future integration of technology with health care will be crucial. Wearable device designers should be aware of the variability in Parkinson disease symptoms and the unique needs of users. Special consideration should be given to Parkinson disease-related health barriers and the users' confidence with technology. In this context, a user-centered design approach that includes people with Parkinson disease in the design of technology will likely be rewarded with improved user engagement and the adoption of and compliance with wearable devices, potentially leading to more accurate disease management, including self-management.", "doi": "10.2196/27418", "pmid": "34989693", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "v6i1e27418"}], "notes": [], "created": "2022-01-10T15:33:59.352Z", "modified": "2022-01-10T15:33:59.759Z"}, {"entity": "publication", "iuid": "9600647319b848768a61f3a666f9c5b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9600647319b848768a61f3a666f9c5b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9600647319b848768a61f3a666f9c5b4"}}, "title": "Quality of training in cervical cancer radical surgery: a survey from the European Network of Young Gynaecologic Oncologists (ENYGO).", "authors": [{"family": "Bizzarri", "given": "Nicol\u00f2", "initials": "N", "orcid": "0000-0002-1727-904X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e74a49b3221461d87f46384492b5b7f.json"}}, {"family": "Pletnev", "given": "Andrei", "initials": "A"}, {"family": "Razumova", "given": "Zoia", "initials": "Z", "orcid": "0000-0001-6598-0896", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f9dd79d57f44a0ab455974d84356528.json"}}, {"family": "Zalewski", "given": "Kamil", "initials": "K"}, {"family": "Theofanakis", "given": "Charalampos", "initials": "C"}, {"family": "Selcuk", "given": "Ilker", "initials": "I"}, {"family": "Nikolova", "given": "Tanja", "initials": "T"}, {"family": "Lanner", "given": "Maximilian", "initials": "M"}, {"family": "G\u00f3mez-Hidalgo", "given": "Natalia R", "initials": "NR", "orcid": "0000-0003-3217-0453", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f3834258eca4d02b3825b5921e452b1.json"}}, {"family": "Kacperczyk-Bartnik", "given": "Joanna", "initials": "J", "orcid": "0000-0003-2539-3894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/471ce2b6e21949a4bcaa0b1aee57d217.json"}}, {"family": "Querleu", "given": "Denis", "initials": "D", "orcid": "0000-0002-3984-4812", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3971070784b9412995250d8c87ebcc27.json"}}, {"family": "Cibula", "given": "David", "initials": "D"}, {"family": "Verheijen", "given": "Ren\u00e9 H M", "initials": "RHM"}, {"family": "Fagotti", "given": "Anna", "initials": "A", "orcid": "0000-0001-5579-335X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd97a1bb600c43b4a47b2080ea6a4438.json"}}], "type": "journal article", "published": "2022-01-06", "journal": {"title": "Int J Gynecol Cancer", "issn": "1525-1438", "issn-l": null}, "abstract": "The European Society of Gynaecological Oncology (ESGO) and partners are committed to improving the training for gynecologic oncology fellows. The aim of this survey was to assess the type and level of training in cervical cancer surgery and to investigate whether the Laparoscopic Approach to Cervical Cancer (LACC) trial results impacted training in radical surgery for gynecologic oncology fellows.\n\nIn June 2020, a 47-question electronic survey was shared with European Network of Young Gynaecologic Oncologists (ENYGO) members. Specialist fellows in obstetrics and gynecology, and gynecologic oncology, from high- and low-volume centers, who started training between January 1, 2017 and January 1, 2020 or started before January 1, 2017 but finished their training at least 6 months after the LACC trial publication (October 2018), were included.\n\n81 of 125 (64.8%) respondents were included. The median time from the start of the fellowship to completion of the survey was 28 months (range 6-48). 56 (69.1%) respondents were still fellows-in-training. 6 of 56 (10.7%) and 14 of 25 (56.0%) respondents who were still in training and completed the fellowship, respectively, performed \u226510 radical hysterectomies during their training. Fellows trained in an ESGO accredited center had a higher chance to perform sentinel lymph node biopsy (60.4% vs 30.3%; p=0.027). There was no difference in the mean number of radical hysterectomies performed by fellows during fellowship before and after the LACC trial publication (8\u00b112.0 vs 7\u00b18.4, respectively; p=0.46). A significant reduction in number of minimally invasive radical hysterectomies was noted when comparing the period before and after the LACC trial (38.5% vs 13.8%, respectively; p<0.001).\n\nExposure to radical surgery for cervical cancer among gynecologic oncology fellows is low. Centralization of cervical cancer cases to high-volume centers may provide an increase in fellows' exposure to radical procedures. The LACC trial publication was associated with a decrease in minimally invasive radical hysterectomies performed by fellows.", "doi": "10.1136/ijgc-2021-002812", "pmid": "34992130", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijgc-2021-002812"}], "notes": [], "created": "2022-01-10T15:31:46.177Z", "modified": "2022-01-10T15:31:46.351Z"}, {"entity": "publication", "iuid": "13d86c561e5a47a79c5193613849a726", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13d86c561e5a47a79c5193613849a726.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13d86c561e5a47a79c5193613849a726"}}, "title": "Psychometric properties of the Fear of COVID-19 Scale: A response to de Medeiros et al. \"Psychometric properties of the Brazilian version of the Fear of COVID-19 Scale (FCV-19S)\".", "authors": [{"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "editorial", "published": "2022-01-06", "journal": {"title": "Curr Psychol", "issn": "1046-1310", "pages": "1-2", "issn-l": null}, "abstract": null, "doi": "10.1007/s12144-021-02686-4", "pmid": "35018078", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "2686"}, {"db": "pmc", "key": "PMC8734124"}], "notes": [], "created": "2022-01-13T21:00:30.676Z", "modified": "2022-01-13T21:00:30.690Z"}, {"entity": "publication", "iuid": "5099542421be45c89ca7a6a5f7f92733", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5099542421be45c89ca7a6a5f7f92733.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5099542421be45c89ca7a6a5f7f92733"}}, "title": "Is There a Link between COVID-19 and Periodontal Disease? A Narrative Review.", "authors": [{"family": "Grigoriadis", "given": "Andreas", "initials": "A", "orcid": "0000-0002-5542-2230", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2031eae513c4a7fa7e10c3bffa33683.json"}}, {"family": "R\u00e4is\u00e4nen", "given": "Ismo T", "initials": "IT"}, {"family": "P\u00e4rn\u00e4nen", "given": "Pirjo", "initials": "P"}, {"family": "Tervahartiala", "given": "Taina", "initials": "T"}, {"family": "Sorsa", "given": "Timo", "initials": "T"}, {"family": "Sakellari", "given": "Dimitra", "initials": "D"}], "type": "journal article", "published": "2022-01-06", "journal": {"title": "Eur J Dent", "issn": "1305-7456", "issn-l": null}, "abstract": "The coronavirus disease-2019 (COVID-19) pandemic greatly affected human well-being, social behavior, global economy, and healthcare systems. Everyday clinical practice in dentistry has been adjusted to the increased hazards of aerosol production by routine dental procedures. The objective of this study was to assess the existing literature to determine possible mechanisms of a relationship between COVID-19 and periodontitis, as well as describe findings from relevant epidemiological studies.Scarce data exist in the literature that directly addresses the relationship between the two diseases. However, several data describe the role of the oral cavity and periodontal tissues as portals of entry of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), and the contribution of cytokines known to be produced in periodontal disease to severe forms of COVID-19. It is also suggested from the current literature that periodontal disease, shown to be associated with systemic diseases such as diabetes mellitus, cardiovascular and respiratory diseases, shares common risk factors with-especially-severe forms of COVID-19.Further clinical studies are required to establish the relationship between these diseases. Oral hygiene performance and intact periodontal tissues can assist in mitigating the pandemic, and it is suggested that dental practitioners can contribute to identifying at-risk patients.", "doi": "10.1055/s-0041-1740223", "pmid": "34991165", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2022-01-10T15:32:00.493Z", "modified": "2022-01-10T15:33:01.416Z"}, {"entity": "publication", "iuid": "96f60f2aefe946beb5a0066138f3fcea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/96f60f2aefe946beb5a0066138f3fcea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/96f60f2aefe946beb5a0066138f3fcea"}}, "title": "Towards an optimal monoclonal antibody with higher binding affinity to the receptor-binding domain of SARS-CoV-2 spike proteins from different variants", "authors": [{"family": "Neamtu", "given": "Andrei", "initials": "A"}, {"family": "Mocci", "given": "Francesca", "initials": "F", "orcid": "0000-0003-1394-9146", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c727688989c44760a562f662759e9159.json"}}, {"family": "Laaksonen", "given": "Aatto", "initials": "A", "orcid": "0000-0001-9783-4535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3643d2a0d8094741960ef22c433ef52e.json"}}, {"family": "Barroso da Silva", "given": "Fernando L", "initials": "FL", "orcid": "0000-0003-2526-2085", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af9b9974afba4701b8c4875200458c79.json"}}], "type": "posted-content", "published": "2022-01-05", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.01.04.474958", "pmid": null, "labels": {"Category: Omicron VoC": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2022-01-21T16:20:52.980Z", "modified": "2022-01-21T16:22:00.578Z"}, {"entity": "publication", "iuid": "0c1b1ad99f3b44578c6c0520a8c6816e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c1b1ad99f3b44578c6c0520a8c6816e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c1b1ad99f3b44578c6c0520a8c6816e"}}, "title": "The ratio of cardiac troponin T to troponin I may indicate non-necrotic troponin release among COVID-19 patients.", "authors": [{"family": "Hammarsten", "given": "Ola", "initials": "O"}, {"family": "Ljungqvist", "given": "Pontus", "initials": "P"}, {"family": "Redfors", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Wernbom", "given": "Mathias", "initials": "M"}, {"family": "Widing", "given": "Hannes", "initials": "H"}, {"family": "Lindahl", "given": "Bertil", "initials": "B"}, {"family": "Salahuddin", "given": "Sabin", "initials": "S"}, {"family": "Sammantar", "given": "Ruwayda", "initials": "R"}, {"family": "Jha", "given": "Sandeep", "initials": "S"}, {"family": "Ravn-Fischer", "given": "Annica", "initials": "A"}, {"family": "Brink", "given": "Magnus", "initials": "M"}, {"family": "Gisslen", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2022-01-05", "journal": {"title": "Clin Chim Acta", "issn": "1873-3492", "issn-l": "0009-8981", "volume": "527", "issue": null, "pages": "33-37"}, "abstract": "Although cardiac troponin T (cTnT) and troponin I(cTnI) are expressed to similar amount in cardiac tissue, cTnI often reach ten-times higher peak levels compared to cTnT in patients with myocardial necrosis such as in acute myocardial infarction (MI). In contrast, similar levels of cTnT and cTnI are observed in other situations such as stable atrial fibrillation and after strenuous exercise.\n\nExamine cTnT and cTnI levels in relation to COVID-19 disease and MI.\n\nClinical and laboratory data from the local hospital from an observational cohort study of 27 patients admitted with COVID-19 and 15 patients with myocardial infarction (MI) that were analyzed with paired cTnT and cTnI measurement during hospital care.\n\nLevels of cTnI were lower than cTnT in COVID-19 patients (TnI/TnT ratio 0.3, IQR: 0.1-0.6). In contrast, levels of cTnI were 11 times higher compared to cTnT in 15 patients with MI (TnI/TnT ratio 11, IQR: 7-14). The peak cTnI/cTnT ratio among the patients with MI following successful percutaneous intervention were 14 (TnI/TnT ratio 14, IQR: 12-23). The 5 COVID-19 patient samples collected under possible necrotic events had a cTnI/cTnT ratio of 5,5 (IQR: 1,9-8,3).\n\nIn patients with COVID-19, cTnT is often elevated to higher levels than cTnI in sharp contrast to patients with MI, indicating that the release of cardiac troponin has a different cause in COVID-19 patients.", "doi": "10.1016/j.cca.2021.12.030", "pmid": "34998858", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S0009-8981(21)00459-9"}, {"db": "pmc", "key": "PMC8744390"}], "notes": [], "created": "2022-01-10T11:51:34.183Z", "modified": "2022-02-06T17:33:39.186Z"}, {"entity": "publication", "iuid": "816288de60f1430e94cf34b9fe9c777c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/816288de60f1430e94cf34b9fe9c777c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/816288de60f1430e94cf34b9fe9c777c"}}, "title": "Psychometric evaluation of fear of COVID-19 Scale (FCV-19S) among Chinese primary and middle schoolteachers, and their students.", "authors": [{"family": "Chen", "given": "I-Hua", "initials": "IH"}, {"family": "Chen", "given": "Chao-Ying", "initials": "CY"}, {"family": "Zhao", "given": "Ke-Yun", "initials": "KY"}, {"family": "Gamble", "given": "Jeffrey H", "initials": "JH"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2022-01-05", "journal": {"title": "Curr Psychol", "issn": "1046-1310", "pages": "1-17", "issn-l": null}, "abstract": "Utilizing a large-scale cross-sectional survey, the present study tested the advanced psychometric properties of Fear of COVID-19 Scale (FCV-19S) in specific populations (i.e., primary and middle schoolteachers, and their students). The present study also examined the association between perceived fear of COVID-19 and psychological distress among home-room teachers (i.e., teachers who teach all their students in one classroom all day) and their students. The results among participants (11,134 teachers and 4,335 students) indicated good internal reliability of FCV-19S and excellent factorial validity with a two-factor structure utilizing these specific populations. Furthermore, the multilevel analysis showed that home-room teachers' psychological distress, but not fear of COVID-19, was positively associated with their students. In sum, the FCV-19S is a useful tool to assess the fear of COVID-19 on potentially vulnerable populations (i.e., primary/middle schoolteachers and their students). Future studies are encouraged to use the present study's findings to investigate possible underlying mechanisms for developing effective coping strategies and interventions.\n\nThe online version contains supplementary material available at 10.1007/s12144-021-02471-3.", "doi": "10.1007/s12144-021-02471-3", "pmid": "35002189", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2471"}, {"db": "pmc", "key": "PMC8727075"}], "notes": [], "created": "2022-01-13T21:11:56.448Z", "modified": "2022-01-13T21:11:56.494Z"}, {"entity": "publication", "iuid": "8f35ecffb0674516a54335b722d34bc9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f35ecffb0674516a54335b722d34bc9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f35ecffb0674516a54335b722d34bc9"}}, "title": "Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16.", "authors": [{"family": "Kozielski", "given": "Frank", "initials": "F"}, {"family": "Sele", "given": "C\u00e9leste", "initials": "C"}, {"family": "Talibov", "given": "Vladimir O", "initials": "VO"}, {"family": "Lou", "given": "Jiaqi", "initials": "J"}, {"family": "Dong", "given": "Danni", "initials": "D"}, {"family": "Wang", "given": "Qian", "initials": "Q"}, {"family": "Shi", "given": "Xinyue", "initials": "X"}, {"family": "Nyblom", "given": "Maria", "initials": "M"}, {"family": "Rogstam", "given": "Annika", "initials": "A"}, {"family": "Krojer", "given": "Tobias", "initials": "T"}, {"family": "Fisher", "given": "Zo\u00eb", "initials": "Z", "orcid": "0000-0001-8287-0269", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84513a785fda44798344a51a5c960ff7.json"}}, {"family": "Knecht", "given": "Wolfgang", "initials": "W", "orcid": "0000-0001-9530-7598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/034349dc8d0a404c9ecb0fa6cb63b44d.json"}}], "type": "journal article", "published": "2022-01-05", "journal": {"title": "RSC Chem Biol", "issn": "2633-0679", "volume": "3", "issue": "1", "pages": "44-55", "issn-l": null}, "abstract": "Since the emergence of SARS-CoV-2 in 2019, Covid-19 has developed into a serious threat to our health, social and economic systems. Although vaccines have been developed in a tour-de-force and are now increasingly available, repurposing of existing drugs has been less successful. There is a clear need to develop new drugs against SARS-CoV-2 that can also be used against future coronavirus infections. Non-structural protein 10 (nsp10) is a conserved stimulator of two enzymes crucial for viral replication, nsp14 and nsp16, exhibiting exoribonuclease and methyltransferase activities. Interfering with RNA proofreading or RNA cap formation represents intervention strategies to inhibit replication. We applied fragment-based screening using nano differential scanning fluorometry and X-ray crystallography to identify ligands targeting SARS-CoV-2 nsp10. We identified four fragments located in two distinct sites: one can be modelled to where it would be located in the nsp14-nsp10 complex interface and the other in the nsp16-nsp10 complex interface. Microscale thermophoresis (MST) experiments were used to quantify fragment affinities for nsp10. Additionally, we showed by MST that the interaction by nsp14 and 10 is weak and thereby that complex formation could be disrupted by small molecules. The fragments will serve as starting points for the development of more potent analogues using fragment growing techniques and structure-based drug design.", "doi": "10.1039/d1cb00135c", "pmid": "35128408", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "d1cb00135c"}, {"db": "pmc", "key": "PMC8729259"}, {"db": "URL", "key": "https://www.rcsb.org/structure/7ORR", "description": "https://www.rcsb.org/structure/7ORR"}, {"db": "URL", "key": "https://www.rcsb.org/structure/7ORU", "description": "https://www.rcsb.org/structure/7ORU"}, {"db": "URL", "key": "https://www.rcsb.org/structure/7ORW", "description": "https://www.rcsb.org/structure/7ORW"}, {"db": "URL", "key": "https://www.rcsb.org/structure/7ORV", "description": "https://www.rcsb.org/structure/7ORV"}, {"db": "URL", "key": "https://zenodo.org/record/5234009#.Ygzu4d_TVBw", "description": "https://zenodo.org/record/5234009#.Ygzu4d_TVBw"}], "notes": [], "created": "2022-02-08T15:12:57.601Z", "modified": "2022-02-16T14:45:03.822Z"}, {"entity": "publication", "iuid": "f5e4a19529c9460db484bb7110e5b52b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f5e4a19529c9460db484bb7110e5b52b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f5e4a19529c9460db484bb7110e5b52b"}}, "title": "Heterologous immunization with inactivated vaccine followed by mRNA booster elicits strong humoral and cellular immune responses against the SARS-CoV-2 Omicron variant", "authors": [{"family": "Zuo", "given": "Fanglei", "initials": "F"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Piralla", "given": "Antonio", "initials": "A"}, {"family": "Bertoglio", "given": "Federico", "initials": "F"}, {"family": "de Campos-Mata", "given": "Leire", "initials": "L"}, {"family": "Wan", "given": "Hui", "initials": "H"}, {"family": "Schubert", "given": "Maren", "initials": "M"}, {"family": "Wang", "given": "Yating", "initials": "Y"}, {"family": "Sun", "given": "Rui", "initials": "R"}, {"family": "Cassaniti", "given": "Irene", "initials": "I"}, {"family": "Vlachiotis", "given": "Stelios", "initials": "S"}, {"family": "Kumagai-Braesch", "given": "Makiko", "initials": "M"}, {"family": "Andr\u00e9ll", "given": "Juni", "initials": "J"}, {"family": "Zhang", "given": "Zhaoxia", "initials": "Z"}, {"family": "Xue", "given": "Yintong", "initials": "Y"}, {"family": "Wenzel", "given": "Esther Veronika", "initials": "EV"}, {"family": "Calzolai", "given": "Luigi", "initials": "L"}, {"family": "Varani", "given": "Luca", "initials": "L"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Chavoshzadeh", "given": "Zahra", "initials": "Z"}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Hust", "given": "Michael", "initials": "M", "orcid": "0000-0003-3418-6045", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0587ca1111f84a61aaf8917a123d49c1.json"}}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}], "type": "posted-content", "published": "2022-01-05", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.01.04.22268755", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Health": null, "Category: Omicron VoC": null}, "xrefs": [], "notes": [], "created": "2022-01-12T20:54:35.413Z", "modified": "2022-01-21T15:44:21.528Z"}, {"entity": "publication", "iuid": "c10a0714bf2a447fac79cff2efabad6c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c10a0714bf2a447fac79cff2efabad6c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c10a0714bf2a447fac79cff2efabad6c"}}, "title": "Suicidal Ideation during the COVID-19 Pandemic among A Large-Scale Iranian Sample: The Roles of Generalized Trust, Insomnia, and Fear of COVID-19.", "authors": [{"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Ehsani", "given": "Narges", "initials": "N"}, {"family": "Ohayon", "given": "Maurice M", "initials": "MM"}, {"family": "Chen", "given": "Shun-Hua", "initials": "SH", "orcid": "0000-0002-6158-5829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22cb281a4d004f29ad4c944f1f6c344c.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2022-01-04", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "volume": "10", "issue": "1", "issn-l": null}, "abstract": "The novel 2019 coronavirus disease (COVID-19) is still not under control globally. The pandemic has caused mental health issues among many different cohorts and suicidal ideation in relation to COVID-19 has been reported in a number of recent studies. Therefore, the present study proposed a model to explain the associations between generalized trust, fear of COVID-19, insomnia, and suicidal ideation during the COVID-19 pandemic among a large-scale Iranian sample. Utilizing cluster sampling with multistage stratification, residents from Qazvin province in Iran were invited to participate in the present study. Adults aged over 18 years (n = 10,843; 6751 [62.3%] females) completed 'paper-and-pencil' questionnaires with the assistance of a trained research assistant. Structural equation modeling (SEM) was applied to understand the associations between generalized trust, fear of COVID-19, insomnia, and suicidal ideation. Slightly over one-fifth of the participants (n = 2252; 20.8%) reported suicidal ideation. Moreover, the SEM results indicated that generalized trust was indirectly associated with suicidal ideation via fear of COVID-19 and insomnia. Furthermore, generalized trust was not directly associated with suicidal ideation. The proposed model was invariant across gender groups, age groups, and participants residing in different areas (i.e., urban vs. rural). Generalized trust might reduce individuals' suicidal ideation during the COVID-19 pandemic period via reduced levels of fear of COVID-19 and insomnia. Healthcare providers and policymakers may want to assist individuals in developing their generalized trust, reducing fear of COVID-19, and improving insomnia problems to avoid possible suicidal behaviors.", "doi": "10.3390/healthcare10010093", "pmid": "35052258", "labels": {"Category: Public Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "healthcare10010093"}], "notes": [], "created": "2022-01-26T10:24:50.075Z", "modified": "2022-01-26T10:24:50.163Z"}, {"entity": "publication", "iuid": "85f1e00155fd49f48d305e0694acae51", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/85f1e00155fd49f48d305e0694acae51.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/85f1e00155fd49f48d305e0694acae51"}}, "title": "Structural basis of Omicron neutralization by affinity-matured public antibodies", "authors": [{"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Pushparaj", "given": "Pradeepa", "initials": "P"}, {"family": "Das", "given": "Hrishikesh", "initials": "H"}, {"family": "Kim", "given": "Changil", "initials": "C"}, {"family": "Kim", "given": "Sungyong", "initials": "S"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Dyrdak", "given": "Robert", "initials": "R", "orcid": "0000-0001-8456-4898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98ad76a0e144478cb3ceabd05c9928b0.json"}}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "H\u00e4llberg", "given": "B Martin", "initials": "BM", "orcid": "0000-0002-6781-0345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea241fd233ca40a6be4ffa1472d2aa06.json"}}], "type": "posted-content", "published": "2022-01-04", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.01.03.474825", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Health": null, "Category: Omicron VoC": null}, "xrefs": [], "notes": [], "created": "2022-01-12T20:56:05.166Z", "modified": "2023-06-19T14:45:01.436Z"}, {"entity": "publication", "iuid": "1731370beba149bda4ea02b21c210e81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1731370beba149bda4ea02b21c210e81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1731370beba149bda4ea02b21c210e81"}}, "title": "Informal caregiver support needs and burden: a survey in Lithuania.", "authors": [{"family": "Biliunaite", "given": "Ieva", "initials": "I", "orcid": "0000-0002-9111-0891", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51a4248a3ff9484bbc49137b51d2f71a.json"}}, {"family": "Kazlauskas", "given": "Evaldas", "initials": "E", "orcid": "0000-0002-6654-6220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/325ffed05ee04a7fb3aefc3dd9e168e1.json"}}, {"family": "Sanderman", "given": "Robbert", "initials": "R"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}], "type": "journal article", "published": "2022-01-04", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "12", "issue": "1", "pages": "e054607", "issn-l": "2044-6055"}, "abstract": "A demand for informal care exists worldwide. Lithuania presents an interesting case example where the need for the informal care is increasing, but relatively little research has been conducted documenting caregivers' experiences and needs.\n\nThe main objective of this study was to investigate Lithuanian informal caregiver characteristics, support needs and burden. In addition, the impact of the COVID-19 on the caregiver's and care receiver's well-being was investigated.\n\nThe study was conducted online between May and September 2020. Informal caregivers and individuals with informal caregiving experiences were invited to participate in the survey. The survey questionnaire comprised 38 multiple-choice items including participant demographic characteristics, availability of the support, support needs, well-being and the impact of the COVID-19 pandemic. In addition, caregiver burden was assessed with the 24-item Caregiver Burden Inventory (CBI).\n\nA total of 226 individuals completed the survey. Most of the participants were women (87.6%). Almost half of the participants (48.7%) were not receiving any support, and a total of 73.9% expressed a need to receive more professional support. Participants were found to experience high burden on the CBI (M=50.21, SD=15.63). Women were found to be significantly more burdened than men (p=0.011). Even though many participants experienced psychological problems (55.8%), only 2.2% were receiving any psychological support. Finally, majority of the participants did not experience any changes in their own (63.7%) or the well-being of their care receiver (68.1%) due to the COVID-19 pandemic.\n\nMost of the participants were identified as intensive caregivers experiencing a high burden. A majority did not experience changes in their well-being due to COVID-19. We propose several recommendations for increasing accessibility and availability of support for informal caregivers in Lithuania based on the study findings.", "doi": "10.1136/bmjopen-2021-054607", "pmid": "34983768", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-054607"}], "notes": [], "created": "2022-01-10T15:42:11.114Z", "modified": "2022-01-10T15:42:27.894Z"}, {"entity": "publication", "iuid": "73e04d2e08b24dcb8c8839169bb1d85b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/73e04d2e08b24dcb8c8839169bb1d85b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/73e04d2e08b24dcb8c8839169bb1d85b"}}, "title": "Evidence of Air and Surface Contamination with SARS-CoV-2 in a Major Hospital in Portugal.", "authors": [{"family": "Silva", "given": "Priscilla Gomes da", "initials": "PGD"}, {"family": "Gon\u00e7alves", "given": "Jos\u00e9", "initials": "J", "orcid": "0000-0003-2191-527X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7bc13d9c6bec4167aca395c18335bae8.json"}}, {"family": "Lopes", "given": "Ariana Isabel Brito", "initials": "AIB"}, {"family": "Esteves", "given": "Nury Alves", "initials": "NA"}, {"family": "Bamba", "given": "Gustavo Emanuel Enes", "initials": "GEE"}, {"family": "Nascimento", "given": "Maria S\u00e3o Jos\u00e9", "initials": "MSJ", "orcid": "0000-0002-6157-4978", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54388d9b1cc447168086583c0ef4f9a5.json"}}, {"family": "Branco", "given": "Pedro T B S", "initials": "PTBS", "orcid": "0000-0002-4163-0936", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b0c4d92fbc947a2b280ab17a64e9247.json"}}, {"family": "Soares", "given": "Ruben R G", "initials": "RRG", "orcid": "0000-0001-5958-5232", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2fc2815bc25c4fb78df63294947ee184.json"}}, {"family": "Sousa", "given": "Sofia I V", "initials": "SIV", "orcid": "0000-0002-4139-673X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f368cca1ed2144718a95ef3632ba7b3a.json"}}, {"family": "Mesquita", "given": "Jo\u00e3o R", "initials": "JR", "orcid": "0000-0001-8769-8103", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/233b221fd5d7472fab41c89a19beadd5.json"}}], "type": "journal article", "published": "2022-01-04", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "1", "issn-l": null}, "abstract": "As the third wave of the COVID-19 pandemic hit Portugal, it forced the country to reintroduce lockdown measures due to hospitals reaching their full capacities. Under these circumstances, environmental contamination by SARS-CoV-2 in different areas of one of Portugal's major Hospitals was assessed between 21 January and 11 February 2021. Air samples (n = 44) were collected from eleven different areas of the Hospital (four COVID-19 and seven non-COVID-19 areas) using Coriolis\u00ae \u03bc and Coriolis\u00ae Compact cyclone air sampling devices. Surface sampling was also performed (n = 17) on four areas (one COVID-19 and three non-COVID-19 areas). RNA extraction followed by a one-step RT-qPCR adapted for quantitative purposes were performed. Of the 44 air samples, two were positive for SARS-CoV-2 RNA (6575 copies/m3 and 6662.5 copies/m3, respectively). Of the 17 surface samples, three were positive for SARS-CoV-2 RNA (200.6 copies/cm2, 179.2 copies/cm2, and 201.7 copies/cm2, respectively). SARS-CoV-2 environmental contamination was found both in air and on surfaces in both COVID-19 and non-COVID-19 areas. Moreover, our results suggest that longer collection sessions are needed to detect point contaminations. This reinforces the need to remain cautious at all times, not only when in close contact with infected individuals. Hand hygiene and other standard transmission-prevention guidelines should be continuously followed to avoid nosocomial COVID-19.", "doi": "10.3390/ijerph19010525", "pmid": "35010785", "labels": {"Category: Other": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph19010525"}], "notes": [], "created": "2022-01-13T21:07:50.384Z", "modified": "2022-01-13T21:07:59.578Z"}, {"entity": "publication", "iuid": "6229e6d010c64da2802a196b60b10ea9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6229e6d010c64da2802a196b60b10ea9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6229e6d010c64da2802a196b60b10ea9"}}, "title": "Scaling the Children Immunization App (CIMA) to Support Child Refugees and Parents in the Time of the COVID-19 Pandemic: A Social Capital Approach to Scale a Smartphone Application in Zaatari Camp, Jordan.", "authors": [{"family": "Khader", "given": "Yousef S", "initials": "YS"}, {"family": "Maalouf", "given": "Wadih", "initials": "W"}, {"family": "Khdair", "given": "Mohammad Abu", "initials": "MA"}, {"family": "Al-Nsour", "given": "Mohannad", "initials": "M"}, {"family": "Aga", "given": "Eresso", "initials": "E"}, {"family": "Khalifa", "given": "Adam", "initials": "A"}, {"family": "Kassasbeh", "given": "Mohamad", "initials": "M"}, {"family": "El-Halabi", "given": "Soha", "initials": "S"}, {"family": "Alfven", "given": "Tobias", "initials": "T"}, {"family": "El-Khatib", "given": "Ziad", "initials": "Z", "orcid": "0000-0003-0756-7280", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31747e0476314de9bf53d8c8f3d1d147.json"}}], "type": "journal article", "published": "2022-01-03", "journal": {"title": "J Epidemiol Glob Health", "issn": "2210-6014", "issn-l": null}, "abstract": "Children vaccination is a key intervention for their survival, especially among refugees. Yet, children vaccination registration is done manually in refugees camps and there is no possibility to send reminders to parents to come back on time. We aimed to boost the parental registration of children's vaccination records on a Children Immunization app (CIMA) while also availing the parents with useful parenting skills under COVID-19-related stress.\n\nWe incorporated United Nations Office on Drugs and Crime (UNODC) Parenting Skills under COVID-19 information material, through CIMA in Arabic and English languages. We recruited 1100 children in February-March 2021, through a community health promotion dissemination approach. A team of two nurses from the local population and two volunteers (one trained nurse and one trained social worker), from the camp, was formed. They promoted the CIMA app at two clinics and through households visits in Zaatari refugee camp. Qualitative data on impressions and observations of the interactions with the Zaatari camp community were also collected.\n\nA total of 1100 children, up to 15 months of age, eligible for vaccination were enrolled in CIMA, whereby the staff explained the content of the app in terms of vaccination schedule, health promotion materials for vaccination and parenting skills to their caregivers. During the household visits, the volunteers identified a total of 70 children that have incomplete history of vaccination records (n = 42/70 girls, 60%). Also, opportunities and challenges for scaling the app were documented.\n\nThe scaling of CIMA as an innovative means of dissemination of risk and health information in challenging context such as refugee camps was feasible. In the context of vaccination needs for children, in refugee settings, such a need is more eminent, particularly in the context of COVID-19.", "doi": "10.1007/s44197-021-00029-x", "pmid": "34978708", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s44197-021-00029-x"}, {"db": "pmc", "key": "PMC8721635"}], "notes": [], "created": "2022-01-04T14:43:02.544Z", "modified": "2022-01-10T15:43:57.754Z"}, {"entity": "publication", "iuid": "790d80d81559486d90955b9d06bec5fb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/790d80d81559486d90955b9d06bec5fb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/790d80d81559486d90955b9d06bec5fb"}}, "title": "COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease - 3rd CIAO AOP Design Workshop.", "authors": [{"family": "Clerbaux", "given": "Laure-Alix", "initials": "LA"}, {"family": "Amig\u00f3", "given": "N\u00faria", "initials": "N"}, {"family": "Amorim", "given": "Maria Jo\u00e3o", "initials": "MJ"}, {"family": "Bal-Price", "given": "Anna", "initials": "A"}, {"family": "Batista Leite", "given": "Sofia", "initials": "S"}, {"family": "Beronius", "given": "Anna", "initials": "A"}, {"family": "Bezemer", "given": "Gillina F G", "initials": "GFG"}, {"family": "Bostroem", "given": "Ann-Charlotte", "initials": "AC"}, {"family": "Carusi", "given": "Annamaria", "initials": "A"}, {"family": "Coecke", "given": "Sandra", "initials": "S"}, {"family": "Concha", "given": "Rachel", "initials": "R"}, {"family": "Daskalopoulos", "given": "Evangelos P", "initials": "EP"}, {"family": "Debernardi", "given": "Francesca", "initials": "F"}, {"family": "Edrosa", "given": "Eizleayne", "initials": "E"}, {"family": "Edwards", "given": "Steve W", "initials": "SW"}, {"family": "Filipovska", "given": "Julija", "initials": "J"}, {"family": "Garcia-Reyero", "given": "Nat\u00e0lia", "initials": "N"}, {"family": "Gavins", "given": "Felicity N E", "initials": "FNE"}, {"family": "Halappanavar", "given": "Sabina", "initials": "S"}, {"family": "Hargreaves", "given": "Alan J", "initials": "AJ"}, {"family": "Hogberg", "given": "Helena T", "initials": "HT"}, {"family": "Huynh", "given": "Myl\u00e8ne T", "initials": "MT"}, {"family": "Jacobson", "given": "Daniel", "initials": "D"}, {"family": "Josephs-Spaulding", "given": "Jonathan", "initials": "J"}, {"family": "Kim", "given": "Young Jun", "initials": "YJ"}, {"family": "Kong", "given": "Hyun Joon", "initials": "HJ"}, {"family": "Krebs", "given": "Catharine E", "initials": "CE"}, {"family": "Lam", "given": "Ann", "initials": "A"}, {"family": "Landesmann", "given": "Brigitte", "initials": "B"}, {"family": "Layton", "given": "Adrienne", "initials": "A"}, {"family": "Lee", "given": "Yong Oh", "initials": "YO"}, {"family": "Macmillan", "given": "Donna S", "initials": "DS"}, {"family": "Mantovani", "given": "Alberto", "initials": "A"}, {"family": "Margiotta-Casaluci", "given": "Luigi", "initials": "L"}, {"family": "Martens", "given": "Marvin", "initials": "M"}, {"family": "Masereeuw", "given": "Rosalinde", "initials": "R"}, {"family": "Mayasich", "given": "Sally A", "initials": "SA"}, {"family": "Mei", "given": "Liang Merlin", "initials": "LM"}, {"family": "Mortensen", "given": "Holly", "initials": "H"}, {"family": "Munoz Pineiro", "given": "Amalia", "initials": "A"}, {"family": "Nymark", "given": "Penny", "initials": "P"}, {"family": "Ohayon", "given": "Elan", "initials": "E"}, {"family": "Ojasi", "given": "Joshi", "initials": "J"}, {"family": "Paini", "given": "Alicia", "initials": "A"}, {"family": "Parissis", "given": "Nikolaos", "initials": "N"}, {"family": "Parvatam", "given": "Surat", "initials": "S"}, {"family": "Pistollato", "given": "Francesca", "initials": "F"}, {"family": "Sachana", "given": "Magdalini", "initials": "M"}, {"family": "S\u00f8rli", "given": "Jorid Birkelund", "initials": "JB"}, {"family": "Sullivan", "given": "Kristie M", "initials": "KM"}, {"family": "Sund", "given": "Jukka", "initials": "J"}, {"family": "Tanabe", "given": "Shihori", "initials": "S"}, {"family": "Tsaioun", "given": "Katya", "initials": "K"}, {"family": "Vinken", "given": "Mathieu", "initials": "M"}, {"family": "Viviani", "given": "Laura", "initials": "L"}, {"family": "Waspe", "given": "Jennifer", "initials": "J"}, {"family": "Willett", "given": "Catherine", "initials": "C"}, {"family": "Wittwehr", "given": "Clemens", "initials": "C"}], "type": "editorial", "published": "2022-01-03", "journal": {"title": "ALTEX", "issn": "1868-596X", "issn-l": null}, "abstract": "On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO workshop. The CIAO project \"Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework\" aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological key events (KE) toward an adverse outcome, such as respiratory distress, anosmia or multiorgan failure. Assembling the individual AOPs into a network highlights shared KEs as central biological nodes involved in multiple outcomes observed in COVID-19 patients. During the workshop, the KEs and AOPs established so far by the CIAO members were presented and positioned on a timeline of the disease course. Modulating factors influencing the progression and severity of the disease were also addressed, as well as factors beyond purely biological phenomena. CIAO relies on an interdisciplinary crowdsourcing effort, therefore, approaches to expand the CIAO network by widening the crowd and reaching stakeholders were also discussed. To conclude the workshop, it was decided that the AOPs/KEs will be further consolidated, integrating viral variants and long COVID when relevant, while an outreach campaign will be launched to broaden the CIAO scientific crowd.", "doi": "10.14573/altex.2112161", "pmid": "35032963", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2022-01-27T08:01:19.129Z", "modified": "2022-01-27T08:01:19.141Z"}, {"entity": "publication", "iuid": "e8c30921f2d5452399e9ee79e9b6029c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e8c30921f2d5452399e9ee79e9b6029c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e8c30921f2d5452399e9ee79e9b6029c"}}, "title": "Inclusion of Essential Universal Health Coverage Services in Essential Packages of Health Services: A Review of 45 Low- and Lower- Middle Income Countries.", "authors": [{"family": "Shekh Mohamed", "given": "Idil", "initials": "I", "orcid": "0000-0001-8793-601X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/530ee0a9cc58442aafd51798fc54a8fe.json"}}, {"family": "Hepburn", "given": "Jasmine Sprague", "initials": "JS", "orcid": "0000-0002-0917-3181", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b48672dcc13b4596a58890e94992ffdf.json"}}, {"family": "Ekman", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0001-7630-7904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1f4d8ed39cc483a802c179c1f37c53d.json"}}, {"family": "Sundewall", "given": "Jesper", "initials": "J", "orcid": "0000-0001-5357-5754", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c5701bdabae44638729d729958821db.json"}}], "type": "journal article", "published": "2022-01-01", "journal": {"title": "Health Syst Reform", "issn": "2328-8620", "volume": "8", "issue": "1", "pages": "e2006587", "issn-l": null}, "abstract": "Expanding service coverage and achieving universal health coverage (UHC) is a priority for many low- and middle-income countries. Though UHC is a long-term goal, its importance and relevance have only increased since the start of the COVID-19 pandemic. The first step on the road to UHC is to define and develop essential packages of health services (EPHSs), a list of clinical and public health services that a government has deemed a priority and is to provide. However, the nature of these lists of services in low- and lower-middle-income countries is largely unknown. This study examines the contents of 45 countries' EPHSs to determine the inclusion of essential UHC (EUHC) services as defined by the Disease Control Priorities, which comprises 21 specific essential packages of interventions. EPHSs were collected from publicly available sources and their contents were analyzed in two stages, firstly, to determine the level of specificity and detail of the content of EPHSs and, secondly, to determine which essential UHC services were included. Findings show that there are large variations in the level of specificity among EPHSs and that though EUHC services are included to a large extent, variations exist regarding which services are included between countries. The results provide an overview of how countries are designing EPHSs as a policy tool and are progressing toward providing a full range of EUHC services. Additionally, the study introduces new tools and methods for UHC policy analysts and researchers to study the contents of EPHSs in future investigations.", "doi": "10.1080/23288604.2021.2006587", "pmid": "35060830", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2022-01-26T10:20:24.847Z", "modified": "2022-01-26T10:20:24.998Z"}, {"entity": "publication", "iuid": "255e08a4b562434cb10d5c4b99e40fbe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/255e08a4b562434cb10d5c4b99e40fbe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/255e08a4b562434cb10d5c4b99e40fbe"}}, "title": "COVID-19 Pulmonary Pathology: The Experience of European Pulmonary Pathologists throughout the First Two Waves of the Pandemic.", "authors": [{"family": "Fortarezza", "given": "Francesco", "initials": "F"}, {"family": "Pezzuto", "given": "Federica", "initials": "F", "orcid": "0000-0002-8023-3108", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f2021982e9bc4f2aa6c75fc8ea679bc5.json"}}, {"family": "Hofman", "given": "Paul", "initials": "P", "orcid": "0000-0003-0431-9353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80753da68c474a46a5fd85c76e468fdb.json"}}, {"family": "Kern", "given": "Izidor", "initials": "I"}, {"family": "Panizo", "given": "Angel", "initials": "A", "orcid": "0000-0001-8405-7378", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3510815aee214ab7bc89ac6ea9af60b6.json"}}, {"family": "von der Th\u00fcsen", "given": "Jan", "initials": "J", "orcid": "0000-0001-9699-4860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/703d4cdc0b10482391d986defbfe0b9a.json"}}, {"family": "Timofeev", "given": "Sergei", "initials": "S", "orcid": "0000-0002-7098-9024", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dbf89525c1b40ae968ebacad2cf26b8.json"}}, {"family": "Gorkiewicz", "given": "Gregor", "initials": "G", "orcid": "0000-0003-1149-4782", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7745a0222ee340a4897d7bd58f6d4e7f.json"}}, {"family": "Berezowska", "given": "Sabina", "initials": "S", "orcid": "0000-0001-5442-9791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61f52024cff94937b61c28841e8f9912.json"}}, {"family": "de Level", "given": "Laurence", "initials": "L", "orcid": "0000-0003-3994-516X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c0844df584e45b88b88f785e3e272cf.json"}}, {"family": "Ortiz-Villal\u00f3n", "given": "Cristian", "initials": "C"}, {"family": "Lunardi", "given": "Francesca", "initials": "F", "orcid": "0000-0001-5792-4683", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/702db0cd99754d57994f3a5f0e2beb4a.json"}}, {"family": "Calabrese", "given": "Fiorella", "initials": "F"}], "type": "journal article", "published": "2022-01-01", "journal": {"title": "Diagnostics (Basel)", "issn": "2075-4418", "volume": "12", "issue": "1", "issn-l": null}, "abstract": "Autoptic studies of patients who died from COVID-19 constitute an important step forward in improving our knowledge in the pathophysiology of SARS-CoV-2 infection. Systematic analyses of lung tissue, the organ primarily targeted by the disease, were mostly performed during the first wave of the pandemic. Analyses of pathological lesions at different times offer a good opportunity to better understand the disease and how its evolution has been influenced mostly by new SARS-CoV-2 variants or the different therapeutic approaches. In this short report we summarize responses collected from a questionnaire survey that investigated important pathological data during the first two pandemic waves (spring-summer 2020; autumn-winter 2020-2021). The survey was submitted to expert lung pathologists from nine European countries involved in autoptic procedures in both pandemic waves. The frequency of each lung lesion was quite heterogeneous among the participants. However, a higher frequency of pulmonary superinfections, both bacterial and especially fungal, was observed in the second wave compared to the first. Obtaining a deeper knowledge of the pathological lesions at the basis of this complex and severe disease, which change over time, is crucial for correct patient management and treatment. Autoptic examination is a useful tool to achieve this goal.", "doi": "10.3390/diagnostics12010095", "pmid": "35054262", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "diagnostics12010095"}], "notes": [], "created": "2022-01-26T10:21:31.500Z", "modified": "2022-01-26T10:21:31.796Z"}, {"entity": "publication", "iuid": "b7ee308346fa414fb9d99656c2200991", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b7ee308346fa414fb9d99656c2200991.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b7ee308346fa414fb9d99656c2200991"}}, "title": "Soluble TNF receptors predict acute kidney injury and mortality in critically ill COVID-19 patients: A prospective observational study", "authors": [{"family": "Sancho Ferrando", "given": "Elena", "initials": "E"}, {"family": "Hanslin", "given": "Katja", "initials": "K"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Larsson", "given": "Anders", "initials": "A", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2be858ab604743b72383dfdcd14689.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}], "type": "journal-article", "published": "2022-01-00", "journal": {"title": "Cytokine", "issn": "1043-4666", "issn-l": null, "volume": "149", "issue": null, "pages": "155727"}, "abstract": null, "doi": "10.1016/j.cyto.2021.155727", "pmid": "34628127", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:53:51.144Z", "modified": "2022-02-15T08:24:46.792Z"}, {"entity": "publication", "iuid": "036acb2ce314488696558f11b81b706b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/036acb2ce314488696558f11b81b706b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/036acb2ce314488696558f11b81b706b"}}, "title": "Salivary IgG to SARS-CoV-2 indicates seroconversion and correlates to serum neutralization in mRNA-vaccinated immunocompromised individuals", "authors": [{"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "Pin", "given": "Elisa", "initials": "E", "orcid": "0000-0002-2158-2674", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5568b1a9e3c456c8ee4a95eaa55b103.json"}}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "S\u00f6derdahl", "given": "Gunnar", "initials": "G"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "Mielke", "given": "Stephan", "initials": "S", "orcid": "0000-0002-8325-9215", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6f17a7cc4774614a3ad5ea9c910d75a.json"}}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Bergman", "given": "Peter", "initials": "P", "orcid": "0000-0003-3306-3713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15b7290255814a7b9a1a97c3cdb2fc26.json"}}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Valentini", "given": "Davide", "initials": "D"}, {"family": "Blennow", "given": "Ola", "initials": "O", "orcid": "0000-0002-7167-7882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2318c3973e66443aa14fceca0908d127.json"}}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Gabarrini", "given": "Giorgio", "initials": "G", "orcid": "0000-0001-6936-4919", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a032980c1f294d1890979602c1a0326c.json"}}, {"family": "Al-Manei", "given": "Khaled", "initials": "K", "orcid": "0000-0003-0787-5849", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b311d335e194bba9d46406e1b73181a.json"}}, {"family": "Alkharaan", "given": "Hassan", "initials": "H"}, {"family": "Sobkowiak", "given": "Micha\u0142 Jacek", "initials": "MJ", "orcid": "0000-0003-2932-1994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f50e79d47d6845a7aeaf6deb5fe545e7.json"}}, {"family": "Yousef", "given": "Jamil", "initials": "J"}, {"family": "Mravinacova", "given": "Sara", "initials": "S"}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Xu", "given": "Xinling", "initials": "X"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K", "orcid": "0000-0001-7679-9494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02d4d3d9ccc547f7ab18ba69493f6a34.json"}}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C", "orcid": "0000-0003-0880-5375", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7394cf1c96945888fc8765568f5407c.json"}}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}, {"family": "Ljunggren", "given": "Hans Gustaf", "initials": "HG"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Aleman", "given": "Soo", "initials": "S", "orcid": "0000-0003-0461-4870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b0edb2db8d840989936f67047ce91de.json"}}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M"}], "type": "journal-article", "published": "2022-01-00", "journal": {"title": "Med (N Y)", "issn": "2666-6340", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Immunocompromised individuals are highly susceptible to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Whether vaccine-induced immunity in these individuals involves oral cavity, a primary site of infection, is presently unknown.\r\n\r\nImmunocompromised patients (n=404) and healthy controls (n=82) participated in a prospective clinical trial (NCT04780659) encompassing two doses of the mRNA BNT162b2 vaccine. Primary immunodeficiency (PID), secondary immunodeficiencies caused by human immunodeficiency virus (HIV) infection, allogeneic hematopoietic stem cell transplantation (HSCT)/chimeric antigen receptor T cell therapy (CAR-T), solid organ transplantation (SOT), and chronic lymphocytic leukemia (CLL) patients were included. Salivary and serum immunoglobulin G (IgG) reactivities to SARS-CoV-2 spike were measured by multiplex bead-based assays and Elecsys\u00ae Anti-SARS-CoV-2 S assay.\r\n\r\nIgG responses to SARS-CoV-2 spike antigens in saliva in HIV and HSCT/CAR-T groups were comparable to healthy controls after vaccination. The PID, SOT, and CLL patients had weaker responses, influenced mainly by disease parameters or immunosuppressants. Salivary responses correlated remarkably well with specific IgG titers and the neutralizing capacity in serum. Receiver operating characteristic curve analysis for the predictive power of salivary IgG yielded AUC=0.95, PPV=90.7% for entire cohort after vaccination.\r\n\r\nSaliva conveys vaccine responses induced by mRNA BNT162b2. The predictive power of salivary Spike-IgG makes it highly suitable for screening vulnerable groups for revaccination.\r\n\r\nKnut and Alice Wallenberg Foundation, Erling Perssons family foundation, Region Stockholm, Swedish Research Council, Karolinska Institutet, Swedish Blood Cancer Foundation, PID patient organization of Sweden, Nordstjernan AB, Center for Medical Innovation (CIMED), Swedish Medical Research Council, Stockholm County Council (ALF).", "doi": "10.1016/j.medj.2022.01.001", "pmid": "35075450", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null, "Research Area: Vaccine": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S2666-6340(22)00036-8"}, {"db": "pmc", "key": "PMC8770252"}], "notes": [], "created": "2022-01-26T08:15:37.719Z", "modified": "2022-02-08T19:21:59.070Z"}, {"entity": "publication", "iuid": "d14fe499bb034711ad8edfcb089c9e8f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d14fe499bb034711ad8edfcb089c9e8f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d14fe499bb034711ad8edfcb089c9e8f"}}, "title": "Robust humoral and cellular immune responses and low risk for reinfection at least 8 months following asymptomatic to mild COVID-19.", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f28f2f6ac9648629c2d2de92fe7bb59.json"}}, {"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/305bca9e5c6c423898c272bf06ce2f2a.json"}}, {"family": "Jernbom Falk", "given": "August", "initials": "A", "orcid": "0000-0002-7773-1851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40d944d7fa964f4292f10012356a2730.json"}}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N", "orcid": "0000-0003-1492-9745", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb052bdf68e4475acf519080b8ac386.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c735ef404391493980e4e51d70459ce0.json"}}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Laur\u00e9n", "given": "Ida", "initials": "I"}, {"family": "Gabrielsson", "given": "Lena", "initials": "L"}, {"family": "Salomonsson", "given": "Ann-Christin", "initials": "AC"}, {"family": "Aguilera", "given": "Katherina", "initials": "K"}, {"family": "Kihlgren", "given": "Martha", "initials": "M"}, {"family": "M\u00e5nsson", "given": "Maja", "initials": "M"}, {"family": "Rosell", "given": "Axel", "initials": "A", "orcid": "0000-0001-6280-0562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4da18c480a2d4c80ad6c7d1f97bbf917.json"}}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C", "orcid": "0000-0003-0880-5375", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7394cf1c96945888fc8765568f5407c.json"}}, {"family": "Andersson", "given": "Eni", "initials": "E"}, {"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc2c612e12284831866002f6759932d5.json"}}, {"family": "Skoglund", "given": "Lovisa", "initials": "L"}, {"family": "Yousef", "given": "Jamil", "initials": "J", "orcid": "0000-0001-5915-1258", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/324e111715fc4029badd136232057025.json"}}, {"family": "Pin", "given": "Elisa", "initials": "E", "orcid": "0000-0002-2158-2674", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5568b1a9e3c456c8ee4a95eaa55b103.json"}}, {"family": "Lord", "given": "Martin", "initials": "M", "orcid": "0000-0002-3238-3187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ddcd91137ed4f8c88b2beb2db340081.json"}}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M", "orcid": "0000-0002-7858-8233", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb515ec509a94036b64bd69339bc2401.json"}}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Tegel", "given": "Hanna", "initials": "H"}, {"family": "D\u00f6nnes", "given": "Pierre", "initials": "P", "orcid": "0000-0002-4613-2952", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6924b18d27749ad99d20c69442ea52b.json"}}, {"family": "Phillipson", "given": "Mia", "initials": "M", "orcid": "0000-0002-2387-0266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/614a4a6f69204c6287a81a79a1a7a8f1.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Mangsbo", "given": "Sara", "initials": "S", "orcid": "0000-0002-1355-2678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cf494629d8a4f9584ada4be16dff66b.json"}}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1345-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a53a433db6f04a458e3d420f0c9995c5.json"}}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": "291", "issue": "1", "pages": "72-80"}, "abstract": "Emerging data support detectable immune responses for months after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination, but it is not yet established to what degree and for how long protection against reinfection lasts.\n\nWe investigated SARS-CoV-2-specific humoral and cellular immune responses more than 8 months post-asymptomatic, mild and severe infection in a cohort of 1884 healthcare workers (HCW) and 51 hospitalized COVID-19 patients. Possible protection against SARS-CoV-2 reinfection was analyzed by a weekly 3-month polymerase chain reaction (PCR) screening of 252 HCW that had seroconverted 7 months prior to start of screening and 48 HCW that had remained seronegative at multiple time points.\n\nAll COVID-19 patients and 96% (355/370) of HCW who were anti-spike IgG positive at inclusion remained anti-spike IgG positive at the 8-month follow-up. Circulating SARS-CoV-2-specific memory T cell responses were detected in 88% (45/51) of COVID-19 patients and in 63% (233/370) of seropositive HCW. The cumulative incidence of PCR-confirmed SARS-CoV-2 infection was 1% (3/252) among anti-spike IgG positive HCW (0.13 cases per 100 weeks at risk) compared to 23% (11/48) among anti-spike IgG negative HCW (2.78 cases per 100 weeks at risk), resulting in a protective effect of 95.2% (95% CI 81.9%-99.1%).\n\nThe vast majority of anti-spike IgG positive individuals remain anti-spike IgG positive for at least 8 months regardless of initial COVID-19 disease severity. The presence of anti-spike IgG antibodies is associated with a substantially reduced risk of reinfection up to 9 months following asymptomatic to mild COVID-19.", "doi": "10.1111/joim.13387", "pmid": "34459525", "labels": {"Research Area: Viral sequence evolution": null, "Research Area: Drug discovery and repurposing of drugs": null, "Category: Biochemistry": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Biobanks for COVID-19 research": null, "Research Area: Host cell systems biology and targets": null}, "xrefs": [{"db": "pmc", "key": "PMC8661920"}], "notes": [], "created": "2021-09-01T07:50:22.235Z", "modified": "2022-02-06T17:12:35.708Z"}, {"entity": "publication", "iuid": "b7c57303c3964ef7ab66ba926324329d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b7c57303c3964ef7ab66ba926324329d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b7c57303c3964ef7ab66ba926324329d"}}, "title": "Rehabilitation needs following COVID-19: Five-month post-discharge clinical follow-up of individuals with concerning self-reported symptoms.", "authors": [{"family": "Wahlgren", "given": "Carl", "initials": "C"}, {"family": "Divanoglou", "given": "Anestis", "initials": "A"}, {"family": "Larsson", "given": "Melanie", "initials": "M"}, {"family": "Nilsson", "given": "Emma", "initials": "E"}, {"family": "\u00d6stholm Balkhed", "given": "\u00c5se", "initials": "\u00c5"}, {"family": "Niward", "given": "Katarina", "initials": "K"}, {"family": "Birberg Thornberg", "given": "Ulrika", "initials": "U"}, {"family": "Lilliecreutz Gudmundsson", "given": "Eva", "initials": "E"}, {"family": "Levi", "given": "Richard", "initials": "R"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": "43", "pages": "101219", "issn-l": null}, "abstract": "This report describes and objectivizes reported problems among a cohort of previously hospitalized COVID-19 patients by clinical examination and determination of the required level of rehabilitation sevices.\n\nThis report forms part of the Link\u00f6ping COVID-19 Study (LinCoS) that included 745 individuals from one of 21 Swedish healthcare regions, Region \u00d6sterg\u00f6tland (R\u00d6), admitted to hospital for COVID-19 during March 1st-May 31st, 2020. In this descriptive ambidirectional cohort study, all 185 individuals who had reported concerning persisting symptoms were invited to a multi-professional clinical assessment of somatic, functional, affective, neuropsychological status and rehabilitation needs. Rehabilitation needs were assessed using three sub-scales of the Rehabilitation Complexity Scale-Extended.\n\nAmong the 158 (85\u00b74%) cases consenting and included in the analysis, we found a broad array of symptoms and signs attributable to COVID-19 involving respiratory, visual, auditory, motor, sensory and cognitive functions that could be confirmed clinically at five months post-discharge. This translated into 16% [95% CI 13-20] of survivors (70/433) of the total regional cohort of hospitalised patients requiring further rehabilitative interventions at follow-up. Weakness in extremities was reported in 28\u00b75% [21\u00b76, 36\u00b72] (45/158). On examination, clinically overt muscle weakness could be corroborated in 15 individuals (10\u00b75%) [6\u00b71, 16\u00b74]. 48% [40, 56] (76/158) reported cognitive symptoms, while the physician noted overt cognitive impairments in only 3% [1\u00b71, 7\u00b75]. In neuropsychological testing, 37% [28-46] (45/122) performed 1.5 SD below the norm, indicating neurocognitive deficits. Fifty-five individuals (34\u00b78%) [27\u00b74, 42\u00b78] reported new or aggravated pain. In three fourths of them, it exerted a 'moderate' or worse detrimental effect on their ability to work.\n\nOur study underscores the importance of providing extensive examination of cases with persisting problems after COVID-19, especially since symptoms such as fatigue and breathlessness are highly nonspecific, but may represent significant underlying functional impairments. Robust neurocognitive testing should be performed, as cognitive problems may easily be overlooked during routine medical consultation. In the Swedish context, most rehabilitative interventions could be provided in a primary care setting. A substantial minority of patients should be triaged to specialized rehabilitation services.", "doi": "10.1016/j.eclinm.2021.101219", "pmid": "34901798", "labels": {"Category: Rehabilitation": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(21)00500-9"}, {"db": "pmc", "key": "PMC8645256"}], "notes": [], "created": "2021-12-18T17:59:27.619Z", "modified": "2021-12-18T17:59:27.633Z"}, {"entity": "publication", "iuid": "67fddc2eeb544fe988649656d7cfb401", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/67fddc2eeb544fe988649656d7cfb401.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/67fddc2eeb544fe988649656d7cfb401"}}, "title": "Reduced risk of hospitalisation among reported COVID-19 cases infected with the SARS-CoV-2 Omicron BA.1 variant compared with the Delta variant, Norway, December 2021 to January 2022.", "authors": [{"family": "Veneti", "given": "Lamprini", "initials": "L"}, {"family": "B\u00f8\u00e5s", "given": "H\u00e5kon", "initials": "H"}, {"family": "Br\u00e5then Kristoffersen", "given": "Anja", "initials": "A"}, {"family": "St\u00e5lcrantz", "given": "Jeanette", "initials": "J"}, {"family": "Bragstad", "given": "Karoline", "initials": "K"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "Storm", "given": "Margrethe Larsdatter", "initials": "ML"}, {"family": "Aasand", "given": "Nina", "initials": "N"}, {"family": "R\u00f8", "given": "Gunnar", "initials": "G"}, {"family": "Starrfelt", "given": "Jostein", "initials": "J"}, {"family": "Sepp\u00e4l\u00e4", "given": "Elina", "initials": "E"}, {"family": "Kv\u00e5le", "given": "Reidar", "initials": "R"}, {"family": "Vold", "given": "Line", "initials": "L"}, {"family": "Nyg\u00e5rd", "given": "Karin", "initials": "K"}, {"family": "Buanes", "given": "Eirik Alnes", "initials": "EA"}, {"family": "Whittaker", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "27", "issue": "4", "issn-l": null}, "abstract": "We included 39,524 COVID-19 Omicron and 51,481 Delta cases reported in Norway from December 2021 to January 2022. We estimated a 73% reduced risk of hospitalisation (adjusted hazard ratio: 0.27; 95% confidence interval: 0.20-0.36) for Omicron compared with Delta. Compared with unvaccinated groups, Omicron cases who had completed primary two-dose vaccination 7-179 days before diagnosis had a lower reduced risk than Delta (66% vs 93%). People vaccinated with three doses had a similar risk reduction (86% vs 88%).", "doi": "10.2807/1560-7917.ES.2022.27.4.2200077", "pmid": "35086614", "labels": {"Category: Health": null, "Category: Omicron VoC": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-31T11:43:40.150Z", "modified": "2022-01-31T11:43:40.164Z"}, {"entity": "publication", "iuid": "b3e8607d21ca42449bcaf014acc8d025", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b3e8607d21ca42449bcaf014acc8d025.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b3e8607d21ca42449bcaf014acc8d025"}}, "title": "Persistent endotheliopathy in the pathogenesis of long COVID syndrome: Comment from von Meijenfeldt et al.", "authors": [{"family": "von Meijenfeldt", "given": "Fien A", "initials": "FA", "orcid": "0000-0003-0274-2414", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76b5cb67f6e243459441f06d41f0816c.json"}}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Adelmeijer", "given": "Jelle", "initials": "J"}, {"family": "Thalin", "given": "Charlotte", "initials": "C"}, {"family": "Lisman", "given": "Ton", "initials": "T", "orcid": "0000-0002-3503-7140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7431e810d13c443ca5dacbf5d368e60b.json"}}], "type": "letter", "published": "2022-01-00", "journal": {"title": "J Thromb Haemost", "issn": "1538-7836", "volume": "20", "issue": "1", "pages": "267-269", "issn-l": null}, "abstract": "To the Editor: With great interest we read the recent brief report by dr. Fogarty and colleagues providing evidence for persistent endothelial cell activation in convalescent COVID-19 patients [1]. The authors showed that plasma levels of von Willebrand factor (VWF), factor VIII, and soluble thrombomodulin were elevated at a median of 68 days after initial COVID-19 symptom resolution or discharge from the hospital. Interestingly, not all these patients experienced severe disease. Levels of endothelial injury markers were associated with long-term symptoms, including dyspnoea, fatigue and concentration impairment, often referred to as long COVID.", "doi": "10.1111/jth.15580", "pmid": "34731533", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8646477"}], "notes": [], "created": "2021-11-08T09:15:44.315Z", "modified": "2022-02-06T17:17:13.773Z"}, {"entity": "publication", "iuid": "46f10e72a5c1456791b0fcee1e08b0ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46f10e72a5c1456791b0fcee1e08b0ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46f10e72a5c1456791b0fcee1e08b0ca"}}, "title": "Modelling the direct virus exposure risk associated with respiratory events.", "authors": [{"family": "Wang", "given": "Jietuo", "initials": "J", "orcid": "0000-0002-0422-8024", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/365ae54f06934c93aff3fd56f6bb03c2.json"}}, {"family": "Dalla Barba", "given": "Federico", "initials": "F"}, {"family": "Roccon", "given": "Alessio", "initials": "A"}, {"family": "Sardina", "given": "Gaetano", "initials": "G"}, {"family": "Soldati", "given": "Alfredo", "initials": "A"}, {"family": "Picano", "given": "Francesco", "initials": "F", "orcid": "0000-0002-3943-8187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b1cf61e22c3421498d87d8df32ef247.json"}}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "J R Soc Interface", "issn": "1742-5662", "volume": "19", "issue": "186", "pages": "20210819", "issn-l": null}, "abstract": "The outbreak of the COVID-19 pandemic highlighted the importance of accurately modelling the pathogen transmission via droplets and aerosols emitted while speaking, coughing and sneezing. In this work, we present an effective model for assessing the direct contagion risk associated with these pathogen-laden droplets. In particular, using the most recent studies on multi-phase flow physics, we develop an effective yet simple framework capable of predicting the infection risk associated with different respiratory activities in different ambient conditions. We start by describing the mathematical framework and benchmarking the model predictions against well-assessed literature results. Then, we provide a systematic assessment of the effects of physical distancing and face coverings on the direct infection risk. The present results indicate that the risk of infection is vastly impacted by the ambient conditions and the type of respiratory activity, suggesting the non-existence of a universal safe distance. Meanwhile, wearing face masks provides excellent protection, effectively limiting the transmission of pathogens even at short physical distances, i.e. 1 m.", "doi": "10.1098/rsif.2021.0819", "pmid": "35016556", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Funder: VR": null}, "xrefs": [{"db": "URL", "key": "http://dx.doi.org/10.6084/m9.figshare.16826374", "description": "http://dx.doi.org/10.6084/m9.figshare.16826374"}], "notes": [], "created": "2022-01-13T21:01:11.242Z", "modified": "2022-01-13T21:03:34.222Z"}, {"entity": "publication", "iuid": "dee615b15b7b408c8ccef80f93daeed6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dee615b15b7b408c8ccef80f93daeed6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dee615b15b7b408c8ccef80f93daeed6"}}, "title": "Initial impacts of the COVID-19 pandemic on sexual and reproductive health service use and unmet need in Britain: findings from a quasi-representative survey (Natsal-COVID).", "authors": [{"family": "Dema", "given": "Emily", "initials": "E"}, {"family": "Gibbs", "given": "Jo", "initials": "J"}, {"family": "Clifton", "given": "Soazig", "initials": "S"}, {"family": "Copas", "given": "Andrew J", "initials": "AJ"}, {"family": "Tanton", "given": "Clare", "initials": "C"}, {"family": "Riddell", "given": "Julie", "initials": "J"}, {"family": "P\u00e9rez", "given": "Raquel Bos\u00f3", "initials": "RB"}, {"family": "Reid", "given": "David", "initials": "D"}, {"family": "Bonell", "given": "Chris", "initials": "C"}, {"family": "Unemo", "given": "Magnus", "initials": "M"}, {"family": "Mercer", "given": "Catherine H", "initials": "CH"}, {"family": "Mitchell", "given": "Kirstin R", "initials": "KR"}, {"family": "Sonnenberg", "given": "Pam", "initials": "P"}, {"family": "Field", "given": "Nigel", "initials": "N"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "Lancet Public Health", "issn": "2468-2667", "volume": "7", "issue": "1", "pages": "e36-e47", "issn-l": null}, "abstract": "The COVID-19 pandemic has affected sexual and reproductive health (SRH) service use and unmet need, but the impact is unknown. We aimed to determine the proportion of participants reporting sexual risk behaviours, SRH service use and unmet need, and to assess remote sexually transmitted infection (STI) testing service use after the first national lockdown in Britain.\n\nWe used data from the National Surveys of Sexual Attitudes and Lifestyles (Natsal)-COVID cross-sectional, quasi-representative web survey (Natsal-COVID Wave 1). Adults aged 18-59 years who resided in England, Scotland, or Wales completed the survey between July 29 and Aug 10, 2020, which included questions about the approximate 4-month period after announcement of the initial lockdown in Britain (March 23, 2020). Quota-based sampling and weighting were used to achieve a quasi-representative population sample. Participants aged 45-59 years were excluded from services analysis due to low rates of SRH service use. Among individuals aged 18-44 years, we estimated reported SRH service use and inability to access, and calculated age-adjusted odds ratios (aORs) among sexually experienced individuals (those reporting any sexual partner in their lifetime) and sexually active individuals (those reporting any sexual partner in the past year). Unweighted denominators and weighted estimates are presented hereafter.\n\n6654 individuals had complete interviews and were included in the analysis. Among 3758 participants aged 18-44 years, 82\u00b70% reported being sexually experienced, and 73\u00b77% reported being sexually active. 20\u00b78% of sexually experienced participants aged 18-44 years reported using SRH services in the 4-month period. Overall, 9\u00b77% of 3108 participants (9\u00b75% of men; 9\u00b79% of women) reported being unable to use a service they needed, although of the participants who reported trying but not being able to use a SRH service at least once, 76\u00b74% of participants also reported an instance of successful use. 5\u00b79% of 1221 sexually active men and 3\u00b76% of 1560 sexually active women reported use of STI-related services and 14\u00b78% of 1728 sexually experienced women reported use of contraceptive services, with SRH service use highest among individuals aged 18-24 years. Sexually active participants reporting condomless sex with new partners since lockdown were much more likely to report using STI-related services than those who did not report condomless sex (aOR 23\u00b78 [95% CI 11\u00b76-48\u00b79]) for men, 10\u00b75 [3\u00b79-28\u00b72] for women) and, among men, were also more likely to have an unsuccessful attempt at STI-service use (aOR 13\u00b73 [5\u00b73-32\u00b79]). Among 106 individuals who reported using STI testing services, 64\u00b74% accessed services remotely (telephone, video, or online). Among 2581 women aged 25-59 years, 2\u00b74% reported cervical screening compared with an estimated 6% in a comparable 4-month period before the pandemic.\n\nMany people accessed SRH care during the initial lockdown; however, young people and those reporting sexual risk behaviours reported difficulties in accessing services and thus such services might need to address a backlog of need.\n\nWellcome Trust, The Economic and Social Research Council, The National Institute for Health Research, Medical Research Council/Chief Scientist Office and Public Health Sciences Unit, and UCL Coronavirus Response Fund.", "doi": "10.1016/S2468-2667(21)00253-X", "pmid": "34995541", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2468-2667(21)00253-X"}], "notes": [], "created": "2022-01-10T15:31:13.250Z", "modified": "2022-01-10T15:31:13.264Z"}, {"entity": "publication", "iuid": "99ed1321db26492d99260e63ebb3cb29", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/99ed1321db26492d99260e63ebb3cb29.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/99ed1321db26492d99260e63ebb3cb29"}}, "title": "Global Behaviors, Perceptions, and the Emergence of Social Norms at the Onset of the COVID-19 Pandemic.", "authors": [{"family": "Hensel", "given": "Lukas", "initials": "L"}, {"family": "Witte", "given": "Marc", "initials": "M"}, {"family": "Caria", "given": "A Stefano", "initials": "AS"}, {"family": "Fetzer", "given": "Thiemo", "initials": "T"}, {"family": "Fiorin", "given": "Stefano", "initials": "S"}, {"family": "G\u00f6tz", "given": "Friedrich M", "initials": "FM"}, {"family": "Gomez", "given": "Margarita", "initials": "M"}, {"family": "Haushofer", "given": "Johannes", "initials": "J"}, {"family": "Ivchenko", "given": "Andriy", "initials": "A"}, {"family": "Kraft-Todd", "given": "Gordon", "initials": "G"}, {"family": "Reutskaja", "given": "Elena", "initials": "E"}, {"family": "Roth", "given": "Christopher", "initials": "C"}, {"family": "Yoeli", "given": "Erez", "initials": "E"}, {"family": "Jachimowicz", "given": "Jon M", "initials": "JM"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "J Econ Behav Organ", "issn": "0167-2681", "issn-l": null, "volume": "193u", "issue": null, "pages": "473-496"}, "abstract": "We conducted a large-scale survey covering 58 countries and over 100,000 respondents between late March and early April 2020 to study beliefs and attitudes towards citizens' and governments' responses at the onset of the COVID-19 pandemic. Most respondents reported holding normative beliefs in support of COVID-19 containment measures, as well as high rates of adherence to these measures. They also believed that their government and their country's citizens were not doing enough and underestimated the degree to which others in their country supported strong behavioral and policy responses to the pandemic. Normative beliefs were strongly associated with adherence, as well as beliefs about others' and the government's response. Lockdowns were associated with greater optimism about others' and the government's response, and improvements in measures of perceived mental well-being; these effects tended to be larger for those with stronger normative beliefs. Our findings highlight how social norms can arise quickly and effectively to support cooperation at a global scale.", "doi": "10.1016/j.jebo.2021.11.015", "pmid": "34955573", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0167-2681(21)00487-X"}, {"db": "pmc", "key": "PMC8684329"}], "notes": [], "created": "2022-01-04T15:24:43.619Z", "modified": "2022-11-22T05:42:28.273Z"}, {"entity": "publication", "iuid": "7468bf355bed49c5a260c0c5f2d0b6eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7468bf355bed49c5a260c0c5f2d0b6eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7468bf355bed49c5a260c0c5f2d0b6eb"}}, "title": "Correction: Effects of the COVID-19 pandemic on patients with inflammatory joint diseases in Sweden: from infection severity to impact on care provision.", "authors": [], "type": "journal article", "published": "2022-01-00", "journal": {"title": "RMD Open", "issn": "2056-5933", "volume": "8", "issue": "1", "issn-l": null}, "abstract": null, "doi": "10.1136/rmdopen-2021-001987corr1", "pmid": "35042729", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "rmdopen-2021-001987corr1"}, {"db": "pmc", "key": "PMC8783965"}], "notes": [], "created": "2022-01-27T07:07:25.027Z", "modified": "2022-01-27T07:07:25.042Z"}, {"entity": "publication", "iuid": "7a040f43e3654844a378be43affb954b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a040f43e3654844a378be43affb954b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a040f43e3654844a378be43affb954b"}}, "title": "Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.", "authors": [{"family": "Fallerini", "given": "Chiara", "initials": "C"}, {"family": "Picchiotti", "given": "Nicola", "initials": "N"}, {"family": "Baldassarri", "given": "Margherita", "initials": "M"}, {"family": "Zguro", "given": "Kristina", "initials": "K"}, {"family": "Daga", "given": "Sergio", "initials": "S"}, {"family": "Fava", "given": "Francesca", "initials": "F"}, {"family": "Benetti", "given": "Elisa", "initials": "E"}, {"family": "Amitrano", "given": "Sara", "initials": "S"}, {"family": "Bruttini", "given": "Mirella", "initials": "M"}, {"family": "Palmieri", "given": "Maria", "initials": "M"}, {"family": "Croci", "given": "Susanna", "initials": "S"}, {"family": "Lista", "given": "Mirjam", "initials": "M"}, {"family": "Beligni", "given": "Giada", "initials": "G"}, {"family": "Valentino", "given": "Floriana", "initials": "F"}, {"family": "Meloni", "given": "Ilaria", "initials": "I"}, {"family": "Tanfoni", "given": "Marco", "initials": "M"}, {"family": "Minnai", "given": "Francesca", "initials": "F"}, {"family": "Colombo", "given": "Francesca", "initials": "F"}, {"family": "Cabri", "given": "Enrico", "initials": "E"}, {"family": "Fratelli", "given": "Maddalena", "initials": "M"}, {"family": "Gabbi", "given": "Chiara", "initials": "C"}, {"family": "Mantovani", "given": "Stefania", "initials": "S"}, {"family": "Frullanti", "given": "Elisa", "initials": "E"}, {"family": "Gori", "given": "Marco", "initials": "M"}, {"family": "Crawley", "given": "Francis P", "initials": "FP"}, {"family": "Butler-Laporte", "given": "Guillaume", "initials": "G"}, {"family": "Richards", "given": "Brent", "initials": "B"}, {"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Ludwig", "given": "Kerstin U", "initials": "KU"}, {"family": "Schulte", "given": "Eva C", "initials": "EC"}, {"family": "Pairo-Castineira", "given": "Erola", "initials": "E"}, {"family": "Baillie", "given": "John Kenneth", "initials": "JK"}, {"family": "Schmidt", "given": "Axel", "initials": "A"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "WES/WGS Working Group Within the HGI", "given": "", "initials": ""}, {"family": "GenOMICC Consortium", "given": "", "initials": ""}, {"family": "GEN-COVID Multicenter Study", "given": "", "initials": ""}, {"family": "Mari", "given": "Francesca", "initials": "F"}, {"family": "Renieri", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-0846-9220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6388ba45f89d4c3b94c4c6c88f97cadb.json"}}, {"family": "Furini", "given": "Simone", "initials": "S"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "Hum Genet", "issn": "0340-6717", "issn-l": null, "volume": "141", "issue": "1", "pages": "147-173"}, "abstract": "The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management.", "doi": "10.1007/s00439-021-02397-7", "pmid": "34889978", "labels": {"Type: Journal article": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pmc", "key": "PMC8661833"}, {"db": "pii", "key": "10.1007/s00439-021-02397-7"}], "notes": [], "created": "2021-12-12T06:48:31.290Z", "modified": "2023-07-13T11:31:18.816Z"}, {"entity": "publication", "iuid": "bd9e593ee2964a518247d66165ff1c1e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bd9e593ee2964a518247d66165ff1c1e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bd9e593ee2964a518247d66165ff1c1e"}}, "title": "Associations of pre-pandemic levels of physical function and physical activity with COVID-19-like symptoms during the outbreak.", "authors": [{"family": "Saadeh", "given": "Marguerita", "initials": "M", "orcid": "0000-0002-2689-5784", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/324dbc9ae7ec4e5daab17e7fab6a183c.json"}}, {"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A"}, {"family": "Vetrano", "given": "Davide Liborio", "initials": "DL"}, {"family": "von Rosen", "given": "Philip", "initials": "P"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Welmer", "given": "Anna-Karin", "initials": "AK"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "Aging Clin Exp Res", "issn": "1720-8319", "volume": "34", "issue": "1", "pages": "235-247", "issn-l": "1594-0667"}, "abstract": "One's physical function and physical activity levels can predispose or protect from the development of respiratory infections. We aimed to explore the associations between pre-pandemic levels of physical function and physical activity and the development of COVID-19-like symptoms in Swedish older adults.\n\nWe analyzed data from 904 individuals aged \u2265 68 years from the population-based Swedish National study on Aging and Care in Kungsholmen. COVID-19-like symptoms were assessed by phone interview (March-June 2020) and included fever, cough, sore throat and/or a cold, headache, pain in muscles, legs and joints, loss of taste and/or odor, breathing difficulties, chest pain, gastrointestinal symptoms, and eye inflammation. Muscle strength, mobility, and physical activity were examined in 2016-2018 by objective testing. Data were analyzed using logistic regression models in the total sample and stratifying by age.\n\nDuring the first outbreak of the pandemic, 325 (36%) individuals from our sample developed COVID-19-like symptoms. Those with slower performance in the chair stand test had an odds ratio (OR) of 1.5 (95% confidence interval [CI] 1.1-2.1) for presenting with COVID-19-like symptoms compared to better performers, after adjusting for potential confounders. The association was even higher among people aged \u2265 80 years (OR 2.6; 95% CI 1.5-4.7). No significant associations were found between walking speed or engagement in moderate-to-vigorous physical activity and the likelihood to develop COVID-19-like symptoms.\n\nPoor muscle strength, a possible indicator of frailty, may predispose older adults to higher odds of developing COVID-19-like symptoms, especially among the oldest-old.", "doi": "10.1007/s40520-021-02006-7", "pmid": "34716912", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8556821"}, {"db": "pii", "key": "10.1007/s40520-021-02006-7"}], "notes": [], "created": "2021-11-01T19:52:53.543Z", "modified": "2023-06-19T15:29:59.121Z"}, {"entity": "publication", "iuid": "4d20e161965b43b89cd46cf341eab89c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4d20e161965b43b89cd46cf341eab89c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4d20e161965b43b89cd46cf341eab89c"}}, "title": "Association between first language and SARS-CoV-2 infection rates, hospitalization, intensive care admissions and death in Finland: a population-based observational cohort study.", "authors": [{"family": "Holmberg", "given": "Ville", "initials": "V"}, {"family": "Salmi", "given": "Heli", "initials": "H"}, {"family": "Kattainen", "given": "Salla", "initials": "S"}, {"family": "Ollgren", "given": "Jukka", "initials": "J"}, {"family": "Kantele", "given": "Anu", "initials": "A"}, {"family": "Pynn\u00f6nen", "given": "Juulia", "initials": "J"}, {"family": "J\u00e4rvinen", "given": "Asko", "initials": "A"}, {"family": "Forsblom", "given": "Erik", "initials": "E"}, {"family": "Sil\u00e9n", "given": "Suvi", "initials": "S"}, {"family": "Kivivuori", "given": "Sanna-Maria", "initials": "SM"}, {"family": "Meretoja", "given": "Atte", "initials": "A"}, {"family": "H\u00e4stbacka", "given": "Johanna", "initials": "J"}], "type": "journal article", "published": "2022-01-00", "journal": {"title": "Clin Microbiol Infect", "issn": "1469-0691", "volume": "28", "issue": "1", "pages": "107-113", "issn-l": null}, "abstract": "Motivated by reports of increased risk of coronavirus disease 2019 (COVID-19) in ethnic minorities of high-income countries, we explored whether patients with a foreign first language are at an increased risk of COVID-19 infections, more serious presentations, or worse outcomes.\n\nIn a retrospective observational population-based quality registry study covering a population of 1.7 million, we studied the incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), admissions to specialist healthcare and the intensive care unit (ICU), and all-cause case fatality in different language groups between 27th February and 3rd August 2020 in Southern Finland. A first language other than Finnish, Swedish or S\u00e1mi served as a surrogate marker for a foreign ethnic background.\n\nIn total, 124 240 individuals were tested, and among the 118 300 (95%) whose first language could be determined, 4005 (3.4%) were COVID-19-positive, 623 (0.5%) were admitted to specialized hospitals, and 147 (0.1%) were admitted to the ICU; 254 (0.2%) died. Those with a foreign first language had lower testing rates (348, 95%CI 340-355 versus 758, 95%CI 753-762 per 10 000, p < 0.0001), higher incidence (36, 95%CI 33-38 versus 22, 95%CI 21-23 per 10 000, p < 0.0001), and higher positivity rates (103, 95%CI 96-109 versus 29, 95%CI 28-30 per 1000, p < 0.0001). There was no significant difference in ICU admissions, disease severity at ICU admission, or ICU outcomes. Case fatality by 90 days was 7.7% in domestic cases and 1.2% in those with a foreign first language, explained by demographics (age- and sex-adjusted HR 0.49, 95%CI 0.21-1.15).\n\nThe population with a foreign first language was at an increased risk for testing positive for SARS-CoV-2, but when hospitalized they had outcomes similar to those in the native, domestic language population. This suggests that special attention should be paid to the prevention and control of infectious diseases among language minorities.", "doi": "10.1016/j.cmi.2021.08.022", "pmid": "34949510", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(21)00484-5"}, {"db": "pmc", "key": "PMC8482016"}], "notes": [], "created": "2022-01-04T15:29:14.195Z", "modified": "2022-01-04T15:29:14.219Z"}, {"entity": "publication", "iuid": "a2842bb0d7a54c41838a25b1708d64d2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2842bb0d7a54c41838a25b1708d64d2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2842bb0d7a54c41838a25b1708d64d2"}}, "title": "Characterizing Post-COVID Syndrome in Outpatient and Inpatient Setting in Sweden Using Diagnosis Codes - A Nationwide Observational Cohort and Matched Cohort Study", "authors": [{"family": "Ollila", "given": "Hanna M", "initials": "HM"}, {"family": "Fonseca", "given": "Osvaldo", "initials": "O"}, {"family": "Caspersen", "given": "Ida Henriette", "initials": "IH"}, {"family": "Kalucza", "given": "Sebastian", "initials": "S"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Trogstad", "given": "Lill", "initials": "L"}, {"family": "Magnus", "given": "Per", "initials": "P"}, {"family": "Hulvej Rod", "given": "Naja", "initials": "N"}, {"family": "Ganna", "given": "Andrea", "initials": "A"}, {"family": "Eriksson", "given": "Marie", "initials": "M"}, {"family": "Fors Connolly", "given": "Anne Marie", "initials": "AM"}], "type": "journal-article", "published": "2022-00-00", "journal": {"title": "SSRN Journal", "issn": "1556-5068", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.2139/ssrn.4276607", "pmid": null, "labels": {"Research Area: Vaccine": null, "Type: Preprint": null, "Category: Health": null, "Topics: Register-based research": null, "Category: Post-COVID": null}, "xrefs": [], "notes": [], "created": "2022-11-29T08:49:10.019Z", "modified": "2022-11-29T09:29:28.220Z"}, {"entity": "publication", "iuid": "5d991aa79d974f8fad60017f9324ba52", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d991aa79d974f8fad60017f9324ba52.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d991aa79d974f8fad60017f9324ba52"}}, "title": "Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges.", "authors": [{"family": "Masterson", "given": "C H", "initials": "CH"}, {"family": "Ceccato", "given": "A", "initials": "A"}, {"family": "Artigas", "given": "A", "initials": "A"}, {"family": "Dos Santos", "given": "C", "initials": "C"}, {"family": "Rocco", "given": "P R", "initials": "PR"}, {"family": "Rolandsson Enes", "given": "S", "initials": "S"}, {"family": "Weiss", "given": "D J", "initials": "DJ"}, {"family": "McAuley", "given": "D", "initials": "D"}, {"family": "Matthay", "given": "M A", "initials": "MA"}, {"family": "English", "given": "K", "initials": "K"}, {"family": "Curley", "given": "G F", "initials": "GF"}, {"family": "Laffey", "given": "J G", "initials": "JG", "orcid": "0000-0002-1246-9573", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9ea7776786048ec82a309a61925d42d.json"}}], "type": "journal article", "published": "2021-12-31", "journal": {"title": "Intensive Care Med Exp", "issn": "2197-425X", "volume": "9", "issue": "1", "pages": "61", "issn-l": null}, "abstract": "Severe viral pneumonia is a significant cause of morbidity and mortality globally, whether due to outbreaks of endemic viruses, periodic viral epidemics, or the rarer but devastating global viral pandemics. While limited anti-viral therapies exist, there is a paucity of direct therapies to directly attenuate viral pneumonia-induced lung injury, and management therefore remains largely supportive. Mesenchymal stromal/stem cells (MSCs) are receiving considerable attention as a cytotherapeutic for viral pneumonia. Several properties of MSCs position them as a promising therapeutic strategy for viral pneumonia-induced lung injury as demonstrated in pre-clinical studies in relevant models. More recently, early phase clinical studies have demonstrated a reassuring safety profile of these cells. These investigations have taken on an added importance and urgency during the COVID-19 pandemic, with multiple trials in progress across the globe. In parallel with clinical translation, strategies are being investigated to enhance the therapeutic potential of these cells in vivo, with different MSC tissue sources, specific cellular products including cell-free options, and strategies to 'licence' or 'pre-activate' these cells, all being explored. This review will assess the therapeutic potential of MSC-based therapies for severe viral pneumonia. It will describe the aetiology and epidemiology of severe viral pneumonia, describe current therapeutic approaches, and examine the data suggesting therapeutic potential of MSCs for severe viral pneumonia in pre-clinical and clinical studies. The challenges and opportunities for MSC-based therapies will then be considered.", "doi": "10.1186/s40635-021-00424-5", "pmid": "34970706", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s40635-021-00424-5"}], "notes": [], "created": "2022-01-04T14:58:20.132Z", "modified": "2022-01-04T14:58:20.209Z"}, {"entity": "publication", "iuid": "2f28263688924fa99d560148ba0d0bec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2f28263688924fa99d560148ba0d0bec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2f28263688924fa99d560148ba0d0bec"}}, "title": "Identifying Risk of Adverse Outcomes in COVID-19 Patients via Artificial Intelligence-Powered Analysis of 12-Lead Intake Electrocardiogram.", "authors": [{"family": "Sridhar", "given": "Arun R", "initials": "AR"}, {"family": "Chen", "given": "Zih-Hua", "initials": "ZH"}, {"family": "Mayfield", "given": "Jacob J", "initials": "JJ"}, {"family": "Fohner", "given": "Alison E", "initials": "AE"}, {"family": "Arvanitis", "given": "Panagiotis", "initials": "P"}, {"family": "Atkinson", "given": "Sarah", "initials": "S"}, {"family": "Braunschweig", "given": "Frieder", "initials": "F"}, {"family": "Chatterjee", "given": "Neal A", "initials": "NA"}, {"family": "Zamponi", "given": "Alessio Falasca", "initials": "AF"}, {"family": "Johnson", "given": "Gregory", "initials": "G"}, {"family": "Joshi", "given": "Sanika A", "initials": "SA"}, {"family": "Lassen", "given": "Mats C H", "initials": "MCH"}, {"family": "Poole", "given": "Jeanne E", "initials": "JE"}, {"family": "Rumer", "given": "Christopher", "initials": "C"}, {"family": "Skaarup", "given": "Kristoffer G", "initials": "KG"}, {"family": "Biering-S\u00f8rensen", "given": "Tor", "initials": "T"}, {"family": "Blomstrom-Lundqvist", "given": "Carina", "initials": "C"}, {"family": "Linde", "given": "Cecilia M", "initials": "CM"}, {"family": "Maleckar", "given": "Mary M", "initials": "MM"}, {"family": "Boyle", "given": "Patrick M", "initials": "PM"}], "type": "journal article", "published": "2021-12-31", "journal": {"title": "Cardiovasc Digit Health J", "issn": "2666-6936", "issn-l": null}, "abstract": "Adverse events in COVID-19 are difficult to predict. Risk stratification is encumbered by the need to protect healthcare workers. We hypothesize that AI can help identify subtle signs of myocardial involvement in the 12-lead electrocardiogram (ECG), which could help predict complications.\n\nUse intake ECGs from COVID-19 patients to train AI models to predict risk of mortality or major adverse cardiovascular events (MACE).\n\nWe studied intake ECGs from 1448 COVID-19 patients (60.5% male, 63.4\u00b116.9 years). Records were labeled by mortality (death vs. discharge) or MACE (no events vs. arrhythmic, heart failure [HF], or thromboembolic [TE] events), then used to train AI models; these were compared to conventional regression models developed using demographic and comorbidity data.\n\n245 (17.7%) patients died (67.3% male, 74.5\u00b114.4 years); 352 (24.4%) experienced at least one MACE (119 arrhythmic; 107 HF; 130 TE). AI models predicted mortality and MACE with area under the curve (AUC) values of 0.60\u00b10.05 and 0.55\u00b10.07, respectively; these were comparable to AUC values for conventional models (0.73\u00b10.07 and 0.65\u00b10.10). There were no prominent temporal trends in mortality rate or MACE incidence in our cohort; holdout testing with data from after a cutoff date (June 9, 2020) did not degrade model performance.\n\nUsing intake ECGs alone, our AI models had limited ability to predict hospitalized COVID-19 patients' risk of mortality or MACE. Our models' accuracy was comparable to that of conventional models built using more in-depth information, but translation to clinical use would require higher sensitivity and positive predictive value. In the future, we hope that mixed-input AI models utilizing both ECG and clinical data may be developed to enhance predictive accuracy.", "doi": "10.1016/j.cvdhj.2021.12.003", "pmid": "35005676", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2666-6936(21)00146-8"}, {"db": "pmc", "key": "PMC8719367"}], "notes": [], "created": "2022-01-13T21:10:16.886Z", "modified": "2022-01-13T21:10:16.926Z"}, {"entity": "publication", "iuid": "0d6ab44032aa4e2780a6e8133916cf4e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d6ab44032aa4e2780a6e8133916cf4e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d6ab44032aa4e2780a6e8133916cf4e"}}, "title": "Baseline knowledge and attitudes on COVID-19 among hotels' staff: A cross-sectional study in Kigali, Rwanda.", "authors": [{"family": "Hagabimana", "given": "Aphrodis", "initials": "A", "orcid": "0000-0003-3658-4020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a791da28dc4401180cf45fe59ed2b8b.json"}}, {"family": "Omolo", "given": "Jared", "initials": "J"}, {"family": "El-Khatib", "given": "Ziad", "initials": "Z"}, {"family": "Rwagasore", "given": "Edson", "initials": "E"}, {"family": "Benemariya", "given": "Noella", "initials": "N"}, {"family": "Nsekuye", "given": "Olivier", "initials": "O"}, {"family": "Kabeja", "given": "Adeline", "initials": "A"}, {"family": "Balisanga", "given": "Helene", "initials": "H"}, {"family": "Umutoni", "given": "Angela", "initials": "A"}, {"family": "Musafili", "given": "Aimable", "initials": "A"}, {"family": "Ndagijimana", "given": "Albert", "initials": "A"}], "type": "journal article", "published": "2021-12-31", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "12", "pages": "e0261744", "issn-l": "1932-6203"}, "abstract": "The World Health Organization declared coronavirus disease 2019 (COVID-19) as a global pandemic on the 11th of March, 2020. Hotels and other public establishments have been associated with higher transmission rates. Sensitisation of staff and strengthening of Infection Prevention and Control (IPC) practices in such settings are important interventions. This study assessed the baseline knowledge and attitudes on COVID-19 among hotels' representatives in Kigali, Rwanda.\n\nA cross-sectional study was conducted among hotels' staff in Kigali in July 2020. A structured questionnaire was self-administered to 104 participants. Baseline knowledge and attitudes were assessed using a number of pre-test questions and mean scores were used to dichotomise the participants' responses as satisfactory or unsatisfactory.\n\nAll of the 104 hotels' staff completed the self-administered questionnaires. Sixty-seven percent (n = 70) were male and 58% (n = 60) were aged between 30 and 44 years. The satisfactory rate of correct answers was 63%\u00b12.4 (n = 66) on knowledge and 68%\u00b11.7 (n = 71) on attitudes evaluation. Participants with University education were more likely to have satisfactory knowledge (AOR: 2.6, 95% C.I: 1.07-6.58) than those with secondary education or less. The staff working in the front-office (AOR: 0.05; 95% CI 0.01-0.54) and housekeeping (AOR: 0.09; 95% C.I: 0.01-0.87) were less likely to have satisfactory attitudes than those working in the administration.\n\nHotels' staff based in the capital of Rwanda have shown satisfactory knowledge and attitudes regarding appropriate IPC practices for preventing the COVID-19 transmission. Educational interventions are needed to improve their knowledge and attitudes for better prevention in this setting.", "doi": "10.1371/journal.pone.0261744", "pmid": "34972131", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-30529"}], "notes": [], "created": "2022-01-04T14:57:44.192Z", "modified": "2022-01-04T14:57:44.255Z"}, {"entity": "publication", "iuid": "2249183c14434629ab13489a5ec18ac4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2249183c14434629ab13489a5ec18ac4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2249183c14434629ab13489a5ec18ac4"}}, "title": "A cohort study of the effect of SARS-CoV-2 point of care rapid RT-PCR at the Emergency Department on targeted admission", "authors": [{"family": "Mortazavi", "given": "Susanne E", "initials": "SE"}, {"family": "Inghammar", "given": "Malin", "initials": "M"}, {"family": "Christiansen", "given": "Claus", "initials": "C"}, {"family": "Pesola", "given": "Anne Katrine", "initials": "AK"}, {"family": "Stenkilsson", "given": "Mikael", "initials": "M"}, {"family": "Paulsson", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1104-2727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0e37d2d03f64fe78a0e84f53922d29f.json"}}], "type": "posted-content", "published": "2021-12-31", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.12.29.21268501", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:42:04.720Z", "modified": "2022-01-04T15:42:04.767Z"}, {"entity": "publication", "iuid": "e4ca08d68b2545e686009a01d2c3b963", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e4ca08d68b2545e686009a01d2c3b963.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e4ca08d68b2545e686009a01d2c3b963"}}, "title": "Toothbrush as a sampling methodology for detection of SARS- CoV-2.", "authors": [{"family": "Gupta", "given": "Shipra", "initials": "S", "orcid": "0000-0003-2097-2459", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa6dd4cea3824827b3ead550b8267b2a.json"}}, {"family": "Mohindra", "given": "Ritin", "initials": "R"}, {"family": "Jain", "given": "Akanksha", "initials": "A"}, {"family": "Singla", "given": "Mohita", "initials": "M"}, {"family": "Sorsa", "given": "Timo", "initials": "T"}, {"family": "R\u00e4is\u00e4nen", "given": "Ismo", "initials": "I", "orcid": "0000-0001-5821-5299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5688183e182e4194888dc98301077bab.json"}}, {"family": "Malhotra", "given": "Meenakshi", "initials": "M"}, {"family": "Soni", "given": "Roop Kishor", "initials": "RK"}, {"family": "Kumar", "given": "Amit", "initials": "A"}, {"family": "Kanta", "given": "Poonam", "initials": "P"}, {"family": "Gauba", "given": "Krishan", "initials": "K"}, {"family": "Singh", "given": "Mini P", "initials": "MP"}, {"family": "Ghosh", "given": "Arnab", "initials": "A"}, {"family": "Suri", "given": "Vikas", "initials": "V"}], "type": "letter", "published": "2021-12-30", "journal": {"title": "Oral Dis", "issn": "1601-0825", "issn-l": null}, "abstract": null, "doi": "10.1111/odi.14122", "pmid": "34967494", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T14:59:04.321Z", "modified": "2022-01-04T14:59:04.366Z"}, {"entity": "publication", "iuid": "c68e747b1b914f13a00ff1399358cd10", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c68e747b1b914f13a00ff1399358cd10.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c68e747b1b914f13a00ff1399358cd10"}}, "title": "Experiences of Stress - A Focus Group Interview Study Among Swedish Adolescents During the COVID-19 Pandemic.", "authors": [{"family": "H\u00f6rbo", "given": "Moa", "initials": "M"}, {"family": "Johansson", "given": "Camilla", "initials": "C"}, {"family": "Garnow", "given": "Tide", "initials": "T"}, {"family": "Garmy", "given": "Pernilla", "initials": "P", "orcid": "0000-0003-1643-0171", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc4733a9e87a42fea6e7a7323feb61b3.json"}}, {"family": "Einberg", "given": "Eva-Lena", "initials": "EL", "orcid": "0000-0002-5586-3810", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d67e636861d492fb682ec1601422cd0.json"}}], "type": "journal article", "published": "2021-12-30", "journal": {"title": "J Sch Nurs", "issn": "1546-8364", "pages": "10598405211071002", "issn-l": null}, "abstract": "Adolescence can be a stressful period in life. The period contains challenges associated with the transition from childhood to adulthood (body changes, changes in interpersonal relationships, and identity changes). The aim was to investigate experiences of stress among adolescents in addition to stress related to the COVID-19 pandemic. Focus group interviews (n = 8) were conducted with girls (n = 22) and boys (n = 19) aged 13-15 in southern Sweden. The transcribed interviews were analyzed with qualitative content analysis. Analysis of the collected material resulted in two categories with four sub-categories each of which highlights adolescents' experiences of stress. The results show that adolescents' have a variety of experiences of stress, i.e., what they mean are the sources of stress and how stress is manifested. The adolescents experienced how stress was manifested both physically and emotionally. This affected both their sleep and performance. The adolescents reflected on both positive and negative manifestations of stress.", "doi": "10.1177/10598405211071002", "pmid": "34967254", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T14:59:47.820Z", "modified": "2022-01-04T14:59:47.935Z"}, {"entity": "publication", "iuid": "cd00b8efc485401f883f70b7c92aeb11", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd00b8efc485401f883f70b7c92aeb11.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd00b8efc485401f883f70b7c92aeb11"}}, "title": "The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males.", "authors": [{"family": "Croci", "given": "Susanna", "initials": "S"}, {"family": "Venneri", "given": "Mary Anna", "initials": "MA"}, {"family": "Mantovani", "given": "Stefania", "initials": "S"}, {"family": "Fallerini", "given": "Chiara", "initials": "C"}, {"family": "Benetti", "given": "Elisa", "initials": "E"}, {"family": "Picchiotti", "given": "Nicola", "initials": "N"}, {"family": "Campolo", "given": "Federica", "initials": "F"}, {"family": "Imperatore", "given": "Francesco", "initials": "F"}, {"family": "Palmieri", "given": "Maria", "initials": "M"}, {"family": "Daga", "given": "Sergio", "initials": "S"}, {"family": "Gabbi", "given": "Chiara", "initials": "C"}, {"family": "Montagnani", "given": "Francesca", "initials": "F"}, {"family": "Beligni", "given": "Giada", "initials": "G"}, {"family": "Farias", "given": "Ticiana D J", "initials": "TDJ"}, {"family": "Carriero", "given": "Miriam Lucia", "initials": "ML"}, {"family": "Di Sarno", "given": "Laura", "initials": "L"}, {"family": "Alaverdian", "given": "Diana", "initials": "D"}, {"family": "Aslaksen", "given": "Sigrid", "initials": "S"}, {"family": "Cubellis", "given": "Maria Vittoria", "initials": "MV"}, {"family": "Spiga", "given": "Ottavia", "initials": "O", "orcid": "0000-0002-0263-7107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc173dee23db417c8875e9c9c8f9125b.json"}}, {"family": "Baldassarri", "given": "Margherita", "initials": "M"}, {"family": "Fava", "given": "Francesca", "initials": "F"}, {"family": "Norman", "given": "Paul J", "initials": "PJ"}, {"family": "Frullanti", "given": "Elisa", "initials": "E"}, {"family": "Isidori", "given": "Andrea M", "initials": "AM", "orcid": "0000-0002-9037-5417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d1bed69cf714996b0a64db788a882f5.json"}}, {"family": "Amoroso", "given": "Antonio", "initials": "A"}, {"family": "Mari", "given": "Francesca", "initials": "F"}, {"family": "Furini", "given": "Simone", "initials": "S"}, {"family": "Mondelli", "given": "Mario U", "initials": "MU"}, {"family": "Chiariello", "given": "Mario", "initials": "M"}, {"family": "Renieri", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-0846-9220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6388ba45f89d4c3b94c4c6c88f97cadb.json"}}, {"family": "Meloni", "given": "Ilaria", "initials": "I"}], "type": "journal article", "published": "2021-12-29", "journal": {"title": "Autophagy", "issn": "1554-8635", "pages": "1-11", "issn-l": null}, "abstract": "The polymorphism L412F in TLR3 has been associated with several infectious diseases. However, the mechanism underlying this association is still unexplored. Here, we show that the L412F polymorphism in TLR3 is a marker of severity in COVID-19. This association increases in the sub-cohort of males. Impaired macroautophagy/autophagy and reduced TNF/TNF\u03b1 production was demonstrated in HEK293 cells transfected with TLR3L412F-encoding plasmid and stimulated with specific agonist poly(I:C). A statistically significant reduced survival at 28 days was shown in L412F COVID-19 patients treated with the autophagy-inhibitor hydroxychloroquine (p = 0.038). An increased frequency of autoimmune disorders such as co-morbidity was found in L412F COVID-19 males with specific class II HLA haplotypes prone to autoantigen presentation. Our analyses indicate that L412F polymorphism makes males at risk of severe COVID-19 and provides a rationale for reinterpreting clinical trials considering autophagy pathways.Abbreviations: AP: autophagosome; AUC: area under the curve; BafA1: bafilomycin A1; COVID-19: coronavirus disease-2019; HCQ: hydroxychloroquine; RAP: rapamycin; ROC: receiver operating characteristic; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2; TLR: toll like receptor; TNF/TNF-\u03b1: tumor necrosis factor.", "doi": "10.1080/15548627.2021.1995152", "pmid": "34964709", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:01:02.575Z", "modified": "2022-01-04T15:01:02.690Z"}, {"entity": "publication", "iuid": "d84e2dd02797453f8032f1c41fa1d769", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d84e2dd02797453f8032f1c41fa1d769.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d84e2dd02797453f8032f1c41fa1d769"}}, "title": "Fear of COVID-19, compliance with recommendations against virus transmission, and attitudes towards vaccination in Sweden.", "authors": [{"family": "H\u00e5kansson", "given": "A", "initials": "A"}, {"family": "Claesdotter", "given": "E", "initials": "E"}], "type": "journal article", "published": "2021-12-29", "journal": {"title": "Heliyon", "issn": "2405-8440", "pages": "e08699", "issn-l": null}, "abstract": "Following the immense impact of the COVID-19 pandemic on health and everyday lives world-wide, people's fear of COVID-19 has been studied in a number of settings using the Fear of COVID scale. In Sweden, virus-preventing strategies have differed from comparable countries, with low use of formal lock-down procedures. It is crucial to study correlates of non-compliance with COVID-19 recommendations, and unwillingness to become vaccinated. This study aims to study whether fear of COVID is associated with mental distress and attitudes towards the pandemic, and to study correlates of non-compliance with key anti-COVID recommendations and with reluctancy to vaccination. This anonymous online survey study in web panel participants (N=1,501) aimed to study a range of behavioral changes during COVID-19. Recommendations and vaccinations reluctancy were analyzed in logistic regressions against socio-demographic data, COVID-19 status, and mental health history. Internal consistency of the Fear of COVID scale was calculated. The Fear of COVID scale had a satisfactory internal consistency (Cronbach-alpha 0.84), and was significantly associated with compliance with all COVID-19 recommendations and with mental health. Non-compliance with recommendations was associated with low fear of disease and younger age, among other variables. Being against vaccination was associated, among other variables, with low fear of disease and with low education. In conclusion, the Fear of COVID scale appears to be associated with key attitudes towards the COVID-19 disease. Anti-virus strategies may need to promote compliance with recommendations in subgroups who feel low fear of disease or who believe not to be in a risk group for severe disease.", "doi": "10.1016/j.heliyon.2021.e08699", "pmid": "34981036", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)02802-4"}, {"db": "pmc", "key": "PMC8716143"}], "notes": [], "created": "2022-01-10T15:42:41.325Z", "modified": "2022-01-10T15:42:41.337Z"}, {"entity": "publication", "iuid": "694fdd8ecb754578a81e168adc034800", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/694fdd8ecb754578a81e168adc034800.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/694fdd8ecb754578a81e168adc034800"}}, "title": "Effect of Previous SARS-CoV-2 Infection on Antibody Response to a Single Immunization with the Pfizer BNT162b mRNA Vaccine Among Healthcare Workers in Foggia, Italy.", "authors": [{"family": "Homan", "given": "Tobias", "initials": "T"}, {"family": "Fortunato", "given": "Francesca", "initials": "F"}, {"family": "Corso", "given": "Gaetano", "initials": "G"}, {"family": "Lopalco", "given": "Pier Luigi", "initials": "PL"}, {"family": "Prato", "given": "Rosa", "initials": "R"}, {"family": "Martinelli", "given": "Domenico", "initials": "D", "orcid": "0000-0001-8028-3167", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84b47c38792d47a39a6ca9ff9d38f502.json"}}], "type": "journal article", "published": "2021-12-29", "journal": {"title": "Infect Dis Ther", "issn": "2193-8229", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Data have suggested that SARS-CoV-2 infection causes an antibody response at least as strong as one BNT162b2 vaccine dose. Nevertheless, some aspects require further investigation to better understand the immunogenicity of one vaccine dose among infected individuals. Thus, we evaluated how previous SARS-CoV-2 infection may influence the humoral immunity after a single Pfizer BNT162b mRNA vaccine dose in a sample of healthcare workers (HCWs).\n\nAs part of the routine surveillance activity conducted among HCWs of the Policlinico Riuniti Foggia Hospital (Apulia region, Italy), we conducted a retrospective serosurvey in the period January-March 2021. We compared specific antibody titres (anti-spike IgGs measured by enzyme-linked immunoassay, ELISA) after SARS-CoV-2 infection and after the first dose of the BNT162b2 vaccine, analysing the impact of sex, age, time since infection, and presence of symptoms on the humoral response.\n\nWe included in the study 58 HCWs (mean age 44.1 years, 48.2% male) with anti-spike IgG titres available before and after the first BNT162b2 vaccine dose. Among these, we observed higher titres in previously infected cases (N = 21) than in COVID-19-na\u00efve subjects (N = 37) (medians 1510 vs. 0.68; p < 0.001). A statistically significant difference in anti-spike IgG titres was also observed among previously infected HCWs before vaccine dose in comparison with post-dose infection-na\u00efve HCWs (medians 18.37 vs. 0.68, p < 0.001). Among infected individuals, no differences by sex, age, or time since infection were reported (p > 0.05). Post-dose titres of symptomatic and asymptomatic infected HCWs slightly differed (medians = 1900 vs. 1090; p = 0.048).\n\nOur data support the viable hypothesis of a single-dose vaccine regimen in individuals with a history of COVID-19, but no conclusion on duration of protection in this group can be drawn from our study.", "doi": "10.1007/s40121-021-00582-9", "pmid": "34964938", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40121-021-00582-9"}, {"db": "pmc", "key": "PMC8715151"}], "notes": [], "created": "2022-01-04T15:00:03.072Z", "modified": "2022-01-04T15:00:42.340Z"}, {"entity": "publication", "iuid": "8b6f545f64ee4f3b9bf47069406c68a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b6f545f64ee4f3b9bf47069406c68a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b6f545f64ee4f3b9bf47069406c68a2"}}, "title": "Biosensor-Enabled Deconvolution of the Avidity-Induced Affinity Enhancement for the SARS-CoV-2 Spike Protein and ACE2 Interaction.", "authors": [{"family": "Gutgsell", "given": "Aspen Rene", "initials": "AR"}, {"family": "Gunnarsson", "given": "Anders", "initials": "A"}, {"family": "Forss\u00e9n", "given": "Patrik", "initials": "P"}, {"family": "Gordon", "given": "Euan", "initials": "E"}, {"family": "Fornstedt", "given": "Torgny", "initials": "T", "orcid": "0000-0002-7123-2066", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53811bd2e7764434b2482324fc9cade9.json"}}, {"family": "Geschwindner", "given": "Stefan", "initials": "S", "orcid": "0000-0002-2154-8345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36d7770aaccf4324a28dc5166afb5eeb.json"}}], "type": "journal article", "published": "2021-12-29", "journal": {"title": "Anal Chem", "issn": "1520-6882", "issn-l": null}, "abstract": "Avidity is an effective and frequent phenomenon employed by nature to achieve extremely high-affinity interactions. As more drug discovery efforts aim to disrupt protein-protein interactions, it is becoming increasingly common to encounter systems that utilize avidity effects and to study these systems using surface-based technologies, such as surface plasmon resonance (SPR) or biolayer interferometry. However, heterogeneity introduced from multivalent binding interactions complicates the analysis of the resulting sensorgram. A frequently applied practice is to fit the data based on a 1:1 binding model, and if the fit does not describe the data adequately, then the experimental setup is changed to favor a 1:1 binding interaction. This reductionistic approach is informative but not always biologically relevant. Therefore, we aimed to develop an SPR-based assay that would reduce the heterogeneity to enable the determination of the kinetic rate constants for multivalent binding interactions using the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and the human receptor angiotensin-converting enzyme 2 (ACE2) as a model system. We employed a combinatorial approach to generate a sensor surface that could distinguish between monovalent and multivalent interactions. Using advanced data analysis algorithms to analyze the resulting sensorgrams, we found that controlling the surface heterogeneity enabled the deconvolution of the avidity-induced affinity enhancement for the SARS-CoV-2 spike protein and ACE2 interaction.", "doi": "10.1021/acs.analchem.1c04372", "pmid": "34964599", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:01:21.322Z", "modified": "2022-01-04T15:10:01.638Z"}, {"entity": "publication", "iuid": "ff01ddd3a9c243118b711c0d1af77ad4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff01ddd3a9c243118b711c0d1af77ad4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff01ddd3a9c243118b711c0d1af77ad4"}}, "title": "A hot topic at the environment-health nexus: Investigating the impact of climate change on infectious diseases.", "authors": [{"family": "Grobusch", "given": "Lena C", "initials": "LC"}, {"family": "Grobusch", "given": "Martin P", "initials": "MP"}], "type": "journal article", "published": "2021-12-29", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712"}, "abstract": "COVID-19 pandemic aside, climate change is the ultimate challenge of our time. However, to date, there has been insufficient political thrust to make that much-needed climate action a reality.\n\nInfectious diseases represent only one facet of the threats arising from climate change. Direct impacts from climate change include the more frequent occurrence and increased magnitude of extreme weather events, as well as changing temperatures and precipitation patterns. For climate-sensitive infectious diseases, these changes implicate a shift in geographic and temporal distribution, seasonality, and transmission intensity.\n\nSusceptibility to deleterious effects of climate change is a net result not only of the interplay of environmental factors but also governed by human, societal, and economic factors, with social inequalities being a major determinant of vulnerability. The global South is already disproportionately affected by the climate crisis. The financial capacity to pursue adaptation options is also limited and unevenly distributed.\n\nClimate change-induced mortality and morbidity from both infectious and non-infectious diseases, amongst other adverse scenarios, is expected to rise globally in the future. The coming decade will be crucial for using all opportunities left to develop and implement adequate mitigation- and adaptation strategies.", "doi": "10.1016/j.ijid.2021.12.350", "pmid": "34973415", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)01250-9"}], "notes": [], "created": "2022-01-04T14:45:52.481Z", "modified": "2022-01-04T14:45:52.494Z"}, {"entity": "publication", "iuid": "2eed46b16b7d48628da3742f43526c30", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2eed46b16b7d48628da3742f43526c30.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2eed46b16b7d48628da3742f43526c30"}}, "title": "Disturbances in sleep, circadian rhythms and daytime functioning in relation to coronavirus infection and Long-COVID - A multinational ICOSS study.", "authors": [{"family": "Merikanto", "given": "Ilona", "initials": "I", "orcid": "0000-0002-1222-6678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50ed32f3146e4c0aa13e934d46eeb4af.json"}}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y"}, {"family": "Chung", "given": "Frances", "initials": "F"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L", "orcid": "0000-0003-3613-6631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e700e607f114414dba66aa366e3158b6.json"}}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK", "orcid": "0000-0002-5745-5474", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bbe4815f36d48959f5e81a5cf650088.json"}}, {"family": "Korman", "given": "Maria", "initials": "M"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "2nd ICOSS members", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-28", "journal": {"title": "J Sleep Res", "issn": "1365-2869", "pages": "e13542", "issn-l": "0962-1105"}, "abstract": "This protocol paper describes the second survey produced by the International Covid Sleep Study (ICOSS) group with the aim to examine the associations between SARS-CoV-2 infection and sleep, sleepiness, and circadian problems as potential predisposing factors for more severe COVID-19 disease profile and for development of Long-COVID in the general population. The survey consists of 47 questions on sleep, daytime sleepiness, circadian rhythm, health, mental wellbeing, life habits, and socioeconomic situation before and during the pandemic, and conditional questions to those reporting having had coronavirus infection, being vaccinated, or suffering from particular sleep symptoms or sleep disorders. Surveys will be administered online between May and November 2021 in Austria, Brazil, Bulgaria, Canada, China, Croatia, Finland, France, Germany, Israel, Italy, Japan, Norway, Portugal, Sweden and USA. Data collected by the survey will give valuable information on the open questions regarding COVID-19 disease risk factors, symptomatology and evolution of Long-COVID, and on other long-term consequences related to the pandemic.", "doi": "10.1111/jsr.13542", "pmid": "34964184", "labels": {"Category: Post-COVID": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:10:20.693Z", "modified": "2022-01-04T15:10:20.746Z"}, {"entity": "publication", "iuid": "ff0ff881a2e04993b01ac47c9fa43740", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff0ff881a2e04993b01ac47c9fa43740.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff0ff881a2e04993b01ac47c9fa43740"}}, "title": "Impact of COVID-19 Lockdown in Eating Disorders: A Multicentre Collaborative International Study.", "authors": [{"family": "Baenas", "given": "Isabel", "initials": "I"}, {"family": "Etxandi", "given": "Mikel", "initials": "M"}, {"family": "Mungu\u00eda", "given": "Lucero", "initials": "L", "orcid": "0000-0002-9751-810X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c45fa0084904a0daa70185f2c205f93.json"}}, {"family": "Granero", "given": "Roser", "initials": "R", "orcid": "0000-0001-6308-3198", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fcdba2a95cdb4c6ca52341bb3eaa8cd6.json"}}, {"family": "Mestre-Bach", "given": "Gemma", "initials": "G", "orcid": "0000-0001-5345-0484", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4bfd9cd50f94f16ae65c3efcb320ef9.json"}}, {"family": "S\u00e1nchez", "given": "Isabel", "initials": "I"}, {"family": "Ortega", "given": "Emilio", "initials": "E", "orcid": "0000-0002-2217-8905", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/967b2d8a952d4a64a3431d6377c9d623.json"}}, {"family": "Andreu", "given": "Alba", "initials": "A", "orcid": "0000-0001-9854-1531", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1ad984c75d446bba8e0b0711f92d492.json"}}, {"family": "Moize", "given": "Violeta L", "initials": "VL"}, {"family": "Fern\u00e1ndez-Real", "given": "Jose-Manuel", "initials": "JM"}, {"family": "Tinahones", "given": "Francisco J", "initials": "FJ"}, {"family": "Di\u00e9guez", "given": "Carlos", "initials": "C"}, {"family": "Fr\u00fchbeck", "given": "Gema", "initials": "G", "orcid": "0000-0002-8305-7154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5f1175d35d1415eb468c233efea3a7d.json"}}, {"family": "Le Grange", "given": "Daniel", "initials": "D", "orcid": "0000-0001-7293-9496", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f4e9d3d0bb3e4d6bbcadb48755345a0b.json"}}, {"family": "Tchanturia", "given": "Kate", "initials": "K", "orcid": "0000-0001-8988-3265", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27ec6341a4ed4a0eb1b9d0b2b4ba26b4.json"}}, {"family": "Karwautz", "given": "Andreas", "initials": "A", "orcid": "0000-0001-9053-998X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6fa0398cf9494fb8a627efe84d8ea526.json"}}, {"family": "Zeiler", "given": "Michael", "initials": "M", "orcid": "0000-0002-7087-6134", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64a514e9d496437a9ca03b3487761c78.json"}}, {"family": "Imgart", "given": "Hartmut", "initials": "H"}, {"family": "Zanko", "given": "Annika", "initials": "A"}, {"family": "Favaro", "given": "Angela", "initials": "A"}, {"family": "Claes", "given": "Laurence", "initials": "L", "orcid": "0000-0002-2287-3158", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05668afa36ac44e0a41baefe3fe15627.json"}}, {"family": "Shekriladze", "given": "Ia", "initials": "I", "orcid": "0000-0002-2787-0503", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6cbb53e06b24d05b7a06e27abe4025c.json"}}, {"family": "Serrano-Troncoso", "given": "Eduardo", "initials": "E"}, {"family": "Cecilia-Costa", "given": "Raquel", "initials": "R"}, {"family": "Rangil", "given": "Teresa", "initials": "T"}, {"family": "Loran-Meler", "given": "Maria Eulalia", "initials": "ME"}, {"family": "Soriano-Pacheco", "given": "Jos\u00e9", "initials": "J"}, {"family": "Carceller-Sindreu", "given": "Mar", "initials": "M"}, {"family": "Navarrete", "given": "Rosa", "initials": "R"}, {"family": "Lozano", "given": "Meritxell", "initials": "M"}, {"family": "Linares", "given": "Raquel", "initials": "R"}, {"family": "Gudiol", "given": "Carlota", "initials": "C"}, {"family": "Carratala", "given": "Jordi", "initials": "J", "orcid": "0000-0003-3209-2563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/457c5afc94f04abf8213883af22e6881.json"}}, {"family": "Plana", "given": "Maria T", "initials": "MT"}, {"family": "Graell", "given": "Montserrat", "initials": "M"}, {"family": "Gonz\u00e1lez-Parra", "given": "David", "initials": "D"}, {"family": "G\u00f3mez-Del Barrio", "given": "Jos\u00e9 A", "initials": "JA", "orcid": "0000-0002-0843-2575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6859029c9c794890b4c413182e6ebd6d.json"}}, {"family": "Sep\u00falveda", "given": "Ana R", "initials": "AR", "orcid": "0000-0002-6041-2889", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17286862c654184bd6d2c372ed2dd34.json"}}, {"family": "S\u00e1nchez-Gonz\u00e1lez", "given": "J\u00e9ssica", "initials": "J"}, {"family": "Machado", "given": "Paulo P P", "initials": "PPP", "orcid": "0000-0003-4277-9203", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78c76a513fda475389e9733feed37285.json"}}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A", "orcid": "0000-0002-5800-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec14ecdcc0654d8ea864f64ce195752b.json"}}, {"family": "T\u00fary", "given": "Ferenc", "initials": "F", "orcid": "0000-0002-7283-5088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6552d5b04a814f7ca33d605d11bb6066.json"}}, {"family": "P\u00e1szthy", "given": "Bea", "initials": "B"}, {"family": "Stein", "given": "Daniel", "initials": "D"}, {"family": "Papezov\u00e1", "given": "Hana", "initials": "H"}, {"family": "Gricova", "given": "Jana", "initials": "J"}, {"family": "Bax", "given": "Brigita", "initials": "B"}, {"family": "Borisenkov", "given": "Mikhail F", "initials": "MF", "orcid": "0000-0002-4310-2010", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9cefa16d6c14d8fbbef76031166b08b.json"}}, {"family": "Popov", "given": "Sergey V", "initials": "SV", "orcid": "0000-0003-1763-8898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/740f23b384674f6681e744c38593bc32.json"}}, {"family": "Gubin", "given": "Denis G", "initials": "DG"}, {"family": "Petrov", "given": "Ivan M", "initials": "IM", "orcid": "0000-0003-0823-3434", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54707d4b6a1c43dd8ced55e544ecbdc8.json"}}, {"family": "Isakova", "given": "Dilara", "initials": "D"}, {"family": "Mustafina", "given": "Svetlana V", "initials": "SV", "orcid": "0000-0003-4716-876X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3822f19c5c474c4784a6cf63b18bfe8f.json"}}, {"family": "Kim", "given": "Youl-Ri", "initials": "YR"}, {"family": "Nakazato", "given": "Michiko", "initials": "M", "orcid": "0000-0002-4025-7594", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1b76b8cf7c947cd96fb042248ab8d71.json"}}, {"family": "Godart", "given": "Nathalie", "initials": "N"}, {"family": "van Voren", "given": "Robert", "initials": "R"}, {"family": "Ilnytska", "given": "Tetiana", "initials": "T", "orcid": "0000-0003-1734-1568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dfd94d8f0d0b43e5abf6732f7b8b7362.json"}}, {"family": "Chen", "given": "Jue", "initials": "J"}, {"family": "Rowlands", "given": "Katie", "initials": "K"}, {"family": "Voderholzer", "given": "Ulrich", "initials": "U", "orcid": "0000-0003-0261-3145", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07d8956c0b9942559bf43303a1df32d5.json"}}, {"family": "Monteleone", "given": "Alessio M", "initials": "AM"}, {"family": "Treasure", "given": "Janet", "initials": "J"}, {"family": "Jim\u00e9nez-Murcia", "given": "Susana", "initials": "S", "orcid": "0000-0002-3596-8033", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ac03a841eb041898475d397a496f40d.json"}}, {"family": "Fern\u00e1ndez-Aranda", "given": "Fernando", "initials": "F", "orcid": "0000-0002-2968-9898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc6962e9696f4bb68aac669a99db8ad6.json"}}], "type": "journal article", "published": "2021-12-27", "journal": {"title": "Nutrients", "issn": "2072-6643", "volume": "14", "issue": "1", "issn-l": null}, "abstract": "The COVID-19 lockdown has had a significant impact on mental health. Patients with eating disorders (ED) have been particularly vulnerable.\n\n(1) To explore changes in eating-related symptoms and general psychopathology during lockdown in patients with an ED from various European and Asian countries; and (2) to assess differences related to diagnostic ED subtypes, age, and geography.\n\nThe sample comprised 829 participants, diagnosed with an ED according to DSM-5 criteria from specialized ED units in Europe and Asia. Participants were assessed using the COVID-19 Isolation Scale (CIES).\n\nPatients with binge eating disorder (BED) experienced the highest impact on weight and ED symptoms in comparison with other ED subtypes during lockdown, whereas individuals with other specified feeding and eating disorders (OFSED) had greater deterioration in general psychological functioning than subjects with other ED subtypes. Finally, Asian and younger individuals appeared to be more resilient.\n\nThe psychopathological changes in ED patients during the COVID-19 lockdown varied by cultural context and individual variation in age and ED diagnosis. Clinical services may need to target preventive measures and adapt therapeutic approaches for the most vulnerable patients.", "doi": "10.3390/nu14010100", "pmid": "35010974", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "nu14010100"}], "notes": [], "created": "2022-01-13T21:06:58.879Z", "modified": "2022-01-13T21:06:59.811Z"}, {"entity": "publication", "iuid": "d488e23ab7044f878bd2c3574727a9a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d488e23ab7044f878bd2c3574727a9a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d488e23ab7044f878bd2c3574727a9a2"}}, "title": "Disease severity related to VOC dominance in unvaccinated SARS-CoV-2 positive adults without risk factors in Sweden", "authors": [{"family": "Wahlstr\u00f6m", "given": "Erik", "initials": "E", "orcid": "0000-0002-0800-8520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f623177f84a4f4ba85571b106e4cec5.json"}}, {"family": "Bruce", "given": "Daniel", "initials": "D"}, {"family": "Bennet Bark", "given": "Anna M", "initials": "AM"}, {"family": "Walther", "given": "Sten", "initials": "S"}, {"family": "Hanberger", "given": "H\u00e5kan", "initials": "H", "orcid": "0000-0002-4199-0229", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ccccceb630874fc5ab7507a313b59039.json"}}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-8801-3169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37509c3832244b019b91a1fe2cbe183e.json"}}], "type": "posted-content", "published": "2021-12-27", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.12.23.21268040", "pmid": null, "labels": {"Type: Preprint": null, "Category: Vaccines": null, "Category: Health": null, "Funder: VR": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:42:57.654Z", "modified": "2022-01-04T15:43:35.405Z"}, {"entity": "publication", "iuid": "0814a4ea41f54f73a151983bdea6511c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0814a4ea41f54f73a151983bdea6511c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0814a4ea41f54f73a151983bdea6511c"}}, "title": "Clinical grade ACE2 effectively inhibits SARS-CoV-2 Omicron infections", "authors": [{"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Stephanie", "given": "Devignot", "initials": "D"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Kellner", "given": "Max J", "initials": "MJ"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Mereiter", "given": "Stefan", "initials": "S"}, {"family": "Knapp", "given": "Sylvia", "initials": "S"}, {"family": "Montserrat", "given": "Nuria", "initials": "N"}, {"family": "Braunsfeld", "given": "Benedict", "initials": "B"}, {"family": "Kozieradzki", "given": "Ivona", "initials": "I"}, {"family": "Ali", "given": "Omar Hasan", "initials": "OH"}, {"family": "Hagelkruys", "given": "Astrid", "initials": "A"}, {"family": "Stadlmann", "given": "Johannes", "initials": "J"}, {"family": "Oostenbrink", "given": "Chris", "initials": "C"}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}], "type": "posted-content", "published": "2021-12-27", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.12.25.474113", "pmid": null, "labels": {"Category: Health": null, "Type: Preprint": null, "Category: Biochemistry": null, "Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null, "Category: Omicron VoC": null}, "xrefs": [], "notes": [], "created": "2022-01-17T10:10:34.079Z", "modified": "2022-01-21T16:21:24.414Z"}, {"entity": "publication", "iuid": "82393755f88348d28f9b87e3f8855197", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82393755f88348d28f9b87e3f8855197.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82393755f88348d28f9b87e3f8855197"}}, "title": "Brand-Specific Enhanced Safety Surveillance Study of GSK's Quadrivalent Seasonal Influenza Vaccine, Conducted During the COVID-19 Pandemic, in Belgium, Germany and Spain, for the 2020/21 Season.", "authors": [{"family": "Dos Santos", "given": "Ga\u00ebl", "initials": "G", "orcid": "0000-0001-8623-3478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e24881d9d6a54aebbc46d19ecd6db87b.json"}}, {"family": "Wang", "given": "Hao", "initials": "H", "orcid": "0000-0001-8293-6969", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1b2f6e2c99943c4ad8699c47c7ffdad.json"}}, {"family": "Jindal", "given": "Pooja", "initials": "P", "orcid": "0000-0001-6528-8875", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ac2ddaacf10499aa5215402e247e31d.json"}}, {"family": "Rybo", "given": "Maria", "initials": "M", "orcid": "0000-0002-6678-0455", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822d718fbc3c49778221473c87ed2c16.json"}}, {"family": "Roul", "given": "H\u00e9l\u00e8ne", "initials": "H", "orcid": "0000-0001-9912-6540", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73b2d969cf3b411ea76655257410a811.json"}}, {"family": "Pallem", "given": "Sridevi", "initials": "S", "orcid": "0000-0002-8435-7132", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f3e1c7911a142f18c155f04959746bc.json"}}, {"family": "Eckermann", "given": "Tamara", "initials": "T"}, {"family": "Godderis", "given": "Lode", "initials": "L", "orcid": "0000-0003-4764-8835", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/639b8bdac78742e9aeebe5b33c6dfedb.json"}}, {"family": "Mart\u00ednez G\u00f3mez", "given": "Xavier", "initials": "X", "orcid": "0000-0003-4583-9734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/17a4aee6258946b388292ad1a0d9255a.json"}}, {"family": "Godard", "given": "Eric", "initials": "E"}, {"family": "Soler", "given": "Muriel", "initials": "M", "orcid": "0000-0002-8169-0730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/63db46695baa4e3c8652cdf990f65d9b.json"}}, {"family": "Yousefi", "given": "Mitra", "initials": "M", "orcid": "0000-0003-3076-5701", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31e3ce5af02d4535aaaf6f440b77e8e7.json"}}, {"family": "Salamanca de la Cueva", "given": "Ignacio", "initials": "I", "orcid": "0000-0003-0561-9913", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ecdb4aaf428b40c78ab014c41fa8e320.json"}}, {"family": "Nwoji", "given": "Ugo", "initials": "U", "orcid": "0000-0002-2946-703X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e630d6f34a914319ba2dd25204adb0fc.json"}}], "type": "journal article", "published": "2021-12-27", "journal": {"title": "Infect Dis Ther", "issn": "2193-8229", "issn-l": null}, "abstract": "Seasonal influenza poses a major public health burden worldwide. Influenza vaccines, updated yearly to match circulating strains based on World Health Organization (WHO) recommendations, are the cornerstone of prevention and require regular monitoring. The COVID-19 pandemic is expected to cause logistical, site access and medical staff constraints and could affect the safety profile of influenza vaccines.\n\nFollowing European Medicines Agency guidance, an enhanced safety surveillance (ESS) study assessed the frequency and severity of predefined and other adverse events (AEs) occurring within 7 days of receiving GSK's inactivated quadrivalent seasonal influenza vaccine (IIV4), in Belgium, Germany and Spain in 2020/21, using adverse drug reaction (ADR) cards.\n\nDuring the 2020/21 influenza season, 1054 participants vaccinated with GSK's IIV4 were enrolled (all adults in Belgium and Germany, 30% adults/70% children in Spain); 96 eligible children received a second dose. Overall, 1042 participants completed the study. After doses 1 and 2, 98.9% and 100% of participants, respectively, returned their completed ADR card. After doses 1 and 2, 37.8% (398/1054) and 13.5% (13/96) of participants, respectively, reported at least one AE. The most frequently reported categories of AEs were \"general disorders and administration site conditions\" (e.g. injection site pain) and \"nervous system disorders\" (e.g. headache). There were no deaths or serious AEs deemed related to GSK's IIV4.\n\nThis ESS study assessed AEs in near real time. The COVID-19 pandemic did not alter the safety profile of GSK's IIV4. No safety signals were detected during the study, which confirms the excellent safety profile of GSK's IIV4.", "doi": "10.1007/s40121-021-00571-y", "pmid": "34961900", "labels": {"Category: Post-COVID": null, "Category: Vaccines": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40121-021-00571-y"}, {"db": "pmc", "key": "PMC8711683"}], "notes": [], "created": "2022-01-04T15:10:47.472Z", "modified": "2022-01-04T15:10:47.851Z"}, {"entity": "publication", "iuid": "339ebb8c228e4553bec7ec6e3ad6f6c8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/339ebb8c228e4553bec7ec6e3ad6f6c8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/339ebb8c228e4553bec7ec6e3ad6f6c8"}}, "title": "A large scale meta-analytic atlas of mental health problems prevalence during the COVID-19 early pandemic.", "authors": [{"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Li", "given": "Han", "initials": "H"}, {"family": "Tsitsas", "given": "George", "initials": "G"}, {"family": "Lee", "given": "Keum Hwa", "initials": "KH"}, {"family": "Choi", "given": "Jiwoo", "initials": "J"}, {"family": "Kim", "given": "Jiwon", "initials": "J"}, {"family": "Choi", "given": "Young Jo", "initials": "YJ"}, {"family": "Tsamakis", "given": "Konstantinos", "initials": "K"}, {"family": "Estrad\u00e9", "given": "Andr\u00e9s", "initials": "A"}, {"family": "Agorastos", "given": "Agorastos", "initials": "A"}, {"family": "Vancampfort", "given": "Davy", "initials": "D"}, {"family": "Tsiptsios", "given": "Dimitrios", "initials": "D"}, {"family": "Thompson", "given": "Trevor", "initials": "T"}, {"family": "Mosina", "given": "Anna", "initials": "A"}, {"family": "Vakadaris", "given": "Georgios", "initials": "G"}, {"family": "Fusar-Poli", "given": "Paolo", "initials": "P"}, {"family": "Carvalho", "given": "Andre F", "initials": "AF"}, {"family": "Correll", "given": "Christoph U", "initials": "CU"}, {"family": "Han", "given": "Young Joo", "initials": "YJ"}, {"family": "Park", "given": "Seoyeon", "initials": "S"}, {"family": "Il Shin", "given": "Jae", "initials": "J"}, {"family": "Solmi", "given": "Marco", "initials": "M"}], "type": "journal article", "published": "2021-12-27", "journal": {"title": "J Med Virol", "issn": "1096-9071", "issn-l": null}, "abstract": "The COVID-19 pandemic and related restrictions can impact mental health. In order to quantify the mental health burden of COVID-19 pandemic, we conducted a systematic review and meta-analysis, searching World Health Organization COVID-19/PsycInfo/PubMed databases (09/29/2020), including observational studies reporting on mental health outcomes in any population affected by COVID-19. Primary outcomes were the prevalence of anxiety, depression, stress, sleep problems, post-traumatic symptoms. Sensitivity analyses were conducted on severe mental health problems, in high-quality studies, and in representative samples. Subgroup analyses were conducted stratified by age, sex, country income level, and COVID-19 infection status. One-hundred-seventy-three studies from February-July 2020 were included (n=502,261, median sample=948, age=34.4 years, females=63%). Ninety-one percent were cross-sectional studies, and 18.5%/57.2% were of high/moderate quality. Highest prevalence emerged for post-traumatic symptoms in COVID-19 infected people (94%), followed by behavioural problems in those with prior mental disorders (77%), fear in healthcare workers (71%), anxiety in caregivers/family members of people with COVID-19 (42%), general health/social contact/passive coping style in the general population (38%), depression in those with prior somatic disorders (37%), and fear in other-than-healthcare workers (29%). Females and people with COVID-19 infection had higher rates of almost all outcomes; college students/young adults of anxiety, depression, sleep problems, suicidal ideation; adults of fear and post-traumatic symptoms. Anxiety, depression, and post-traumatic symptoms were more prevalent in low-/middle-income countries, sleep problems in high-income countries. The COVID-19 pandemic adversely impacts mental health in unique manners across population subgroups. Our results inform tailored preventive strategies and interventions to mitigate current, future, and transgenerational adverse mental health of the COVID-19 pandemic. This article is protected by copyright. All rights reserved.", "doi": "10.1002/jmv.27549", "pmid": "34958144", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:24:01.051Z", "modified": "2022-01-04T15:24:28.475Z"}, {"entity": "publication", "iuid": "12990ec8a3de4a1cb085b315d2fe3209", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/12990ec8a3de4a1cb085b315d2fe3209.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/12990ec8a3de4a1cb085b315d2fe3209"}}, "title": "Validating Insomnia Severity Index (ISI) in a Bangladeshi Population: Using Classical Test Theory and Rasch Analysis.", "authors": [{"family": "Mamun", "given": "Mohammed A", "initials": "MA", "orcid": "0000-0002-1728-8966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6e65a5a97154d159a63cc2ce3f1b7a8.json"}}, {"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Gozal", "given": "David", "initials": "D", "orcid": "0000-0001-8195-6036", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50940954296643fabb4d15a69d4e4bb4.json"}}, {"family": "Manzar", "given": "Md Dilshad", "initials": "MD", "orcid": "0000-0002-5571-3310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/003777905ef4485fa4fd18c9f0cc16ec.json"}}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Huang", "given": "Ru-Yi", "initials": "RY", "orcid": "0000-0001-6867-7171", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3169b8bbbc4f4409961cbd2cf47b2c6b.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-12-25", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "1", "issn-l": null}, "abstract": "The COVID-19 outbreak is associated with sleep problems and mental health issues among individuals. Therefore, there is a need to assess sleep efficiency during this tough period. Unfortunately, the commonly used instrument on insomnia severity-the Insomnia Severity Index (ISI)-has never been translated and validated among Bangladeshis. Additionally, the ISI has never been validated during a major protracted disaster (such as the COVID-19 outbreak) when individuals encounter mental health problems. The present study aimed to translate the ISI into Bangla language (ISI-Bangla) and validate its psychometric properties. First, the linguistic validity of the ISI-Bangla was established. Then, 9790 Bangladeshis (mean age = 26.7 years; SD = 8.5; 5489 [56.1%] males) completed the Bangla versions of the following questionnaires: ISI, Fear of COVID-19 Scale (FCV-19S), and Patient Health Questionnaire-9 (PHQ-9). All the participants also answered an item on suicidal ideation. Classical test theory and Rasch analyses were conducted to evaluate the psychometric properties of the ISI-Bangla. Both classical test theory and Rasch analyses support a one-factor structure for the ISI-Bangla. Moreover, no substantial differential item functioning was observed across different subgroups (gender, depression status (determined using PHQ-9), and suicidal ideation). Additionally, concurrent validity of the ISI-Bangla was supported by significant and moderate correlations with FCV-19S and PHQ-9; known-group validity was established by the significant difference of the ISI-Bangla scores between participants who experienced suicidal ideation and those without. The present psychometric validation conducted during the COVID-19 outbreak suggests that the ISI-Bangla is a promising and operationally adequate instrument to assess insomnia in Bangladeshis.", "doi": "10.3390/ijerph19010225", "pmid": "35010485", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph19010225"}], "notes": [], "created": "2022-01-13T21:08:26.021Z", "modified": "2022-01-13T21:08:26.201Z"}, {"entity": "publication", "iuid": "d3698936851f43e5bff38669fd8afc2e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3698936851f43e5bff38669fd8afc2e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3698936851f43e5bff38669fd8afc2e"}}, "title": "Surgical helmets can be converted into efficient disinfectable powered air-purifying respirators.", "authors": [{"family": "Temmesfeld", "given": "Max", "initials": "M"}, {"family": "Gorzkowska-Sobas", "given": "Agnieszka Anna", "initials": "AA"}, {"family": "Hedlund", "given": "Kenny", "initials": "K"}, {"family": "\u00d8yen", "given": "Martin \u00d8hlund", "initials": "M\u00d8"}, {"family": "Kanten", "given": "Lars", "initials": "L"}, {"family": "Grant", "given": "Peter", "initials": "P"}, {"family": "Jakobsen", "given": "Rune B", "initials": "RB"}], "type": "journal article", "published": "2021-12-25", "journal": {"title": "Am J Infect Control", "issn": "1527-3296", "issn-l": null}, "abstract": "Filtering facepiece respirators often fail to provide sufficient protection due to a poor fit. Powered air-purifying respirators (PAPRs) are not designed for healthcare personnel, and are challenging to disinfect. Surgical helmets (SH) are available in many US hospitals but do not provide respiratory protection. Several modifications to SH have been suggested, but none are sufficiently compliant with safety and efficiency standards. The purpose of this investigation was the development of a filter adaptor, which converts SHs into efficient, safe and disinfectable PAPRs.\n\nFour critical features were investigated close to regulatory requirements: total inward leakage (TIL) of particles, CO2 concentrations, intra-helmet differential pressure, and automated disinfection.\n\nThe average TIL in the two independent tests were 0.005% and 0.01%. CO2 concentrations were lower than in the original SH. The modification generates a positive differential pressure. The filter's performance was not compromised after 50 cycles in a sterilization machine.\n\nThe modified SH provides several hundred times better protection than FFP-3 masks.\n\nSurgical helmets can be modified into safe, efficient, and disinfectable PAPRs, suitable for HCP and the OR in particular. They can play a role in the preparedness for upcoming events requiring efficient respiratory protection.", "doi": "10.1016/j.ajic.2021.12.002", "pmid": "34958857", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0196-6553(21)00841-5"}], "notes": [], "created": "2022-01-04T15:23:41.932Z", "modified": "2022-01-04T15:23:41.946Z"}, {"entity": "publication", "iuid": "492db880c06643539af84fc60d1a3e89", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/492db880c06643539af84fc60d1a3e89.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/492db880c06643539af84fc60d1a3e89"}}, "title": "Influenza A H1N1\u2013mediated pre-existing immunity to SARS-CoV-2 predicts COVID-19 outbreak dynamics", "authors": [{"family": "Almaz\u00e1n", "given": "Nerea Mart\u00edn", "initials": "NM"}, {"family": "Rahbar", "given": "Afsar", "initials": "A"}, {"family": "Carlsson", "given": "Marcus", "initials": "M"}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Kolstad", "given": "Linda", "initials": "L"}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B"}, {"family": "Pantalone", "given": "Mattia Russel", "initials": "MR"}, {"family": "Fuchs", "given": "Ilona Lewensohn", "initials": "IL"}, {"family": "Naucl\u00e9r", "given": "Anna", "initials": "A"}, {"family": "Ohlin", "given": "Mats", "initials": "M"}, {"family": "Sacharczuk", "given": "Mariusz", "initials": "M"}, {"family": "Religa", "given": "Piotr", "initials": "P"}, {"family": "Am\u00e9r", "given": "Stefan", "initials": "S"}, {"family": "Moln\u00e1r", "given": "Christian", "initials": "C"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Susrud", "given": "Andres", "initials": "A"}, {"family": "S\u00f6rensen", "given": "Birger", "initials": "B"}, {"family": "S\u00f6derberg-Naucl\u00e9r", "given": "Cecilia", "initials": "C"}], "type": "posted-content", "published": "2021-12-25", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.12.23.21268321", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null, "Category: Genomics & transcriptomics": null, "Funder: KAW/SciLifeLab": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Drug discovery and repurposing of drugs": null, "Category: Omicron VoC": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:44:30.390Z", "modified": "2022-02-14T14:40:41.897Z"}, {"entity": "publication", "iuid": "28e70e03c04d4f56aa48b44cb2361a06", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/28e70e03c04d4f56aa48b44cb2361a06.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/28e70e03c04d4f56aa48b44cb2361a06"}}, "title": "Acute Stress in Health Workers during Two Consecutive Epidemic Waves of COVID-19.", "authors": [{"family": "J\u00e1uregui Renaud", "given": "Kathrine", "initials": "K", "orcid": "0000-0002-2165-1422", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15f62be9e24a4fac9cdbcdeaafcdf713.json"}}, {"family": "Cooper-Bribiesca", "given": "Davis", "initials": "D", "orcid": "0000-0002-4273-1181", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a29e74edc3fd4cad8860996e46014d6f.json"}}, {"family": "Mart\u00ednez-Pichardo", "given": "Elizabet", "initials": "E"}, {"family": "Miguel Puga", "given": "Jos\u00e9 A", "initials": "JA"}, {"family": "Rasc\u00f3n-Mart\u00ednez", "given": "Dulce M", "initials": "DM", "orcid": "0000-0002-3074-679X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ecd8f18e63eb4506b0ac6bfbcf01c4da.json"}}, {"family": "S\u00e1nchez Hurtado", "given": "Luis A", "initials": "LA"}, {"family": "Colin Mart\u00ednez", "given": "Tania", "initials": "T"}, {"family": "Espinosa-Poblano", "given": "Eliseo", "initials": "E"}, {"family": "Anda-Garay", "given": "Juan Carlos", "initials": "JC"}, {"family": "Gonz\u00e1lez Diaz", "given": "Jorge I", "initials": "JI"}, {"family": "Carde\u00f1a", "given": "Etzel", "initials": "E"}, {"family": "Avelar Garnica", "given": "Francisco", "initials": "F"}], "type": "journal article", "published": "2021-12-25", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "19", "issue": "1", "issn-l": null}, "abstract": "The COVID-19 pandemic has provoked generalized uncertainty around the world, with health workers experiencing anxiety, depression, burnout, insomnia, and stress. Although the effects of the pandemic on mental health may change as it evolves, the majority of reports have been web-based, cross-sectional studies. We performed a study assessing acute stress in frontline health workers during two consecutive epidemic waves. After screening for trait anxiety/depression and dissociative experiences, we evaluated changes in acute stress, considering resilience, state anxiety, burnout, depersonalization/derealization symptoms, and quality of sleep as cofactors. During the first epidemic wave (April 2020), health workers reported acute stress related to COVID-19, which was related to state anxiety. After the first epidemic wave, acute stress decreased, with no increase during the second epidemic wave (December 2020), and further decreased when vaccination started. During the follow-up (April 2020 to February 2021), the acute stress score was related to bad quality of sleep. However, acute stress, state anxiety, and burnout were all related to trait anxiety/depression, while the resilience score was invariant through time. Overall, the results emphasize the relevance of mental health screening before, during, and after an epidemic wave of infections, in order to enable coping during successive sanitary crises.", "doi": "10.3390/ijerph19010206", "pmid": "35010465", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph19010206"}], "notes": [], "created": "2022-01-13T21:08:44.552Z", "modified": "2022-01-13T21:08:44.686Z"}, {"entity": "publication", "iuid": "c7a4115a060d4271ae3121c23213beaf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7a4115a060d4271ae3121c23213beaf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7a4115a060d4271ae3121c23213beaf"}}, "title": "The incidence of melanoma during the COVID-19 pandemic in a Swedish health care region without lockdown.", "authors": [{"family": "Pissa", "given": "Maria", "initials": "M"}, {"family": "Gulin", "given": "Sandra Jerkovic", "initials": "SJ"}], "type": "journal article", "published": "2021-12-24", "journal": {"title": "JAAD Int", "issn": "2666-3287", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jdin.2021.12.004", "pmid": "34977816", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-3287(21)00104-8"}, {"db": "pmc", "key": "PMC8702400"}], "notes": [], "created": "2022-01-04T14:44:22.298Z", "modified": "2022-01-04T14:44:22.336Z"}, {"entity": "publication", "iuid": "6f7c3e78cc6a451989d470d385d4948e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f7c3e78cc6a451989d470d385d4948e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f7c3e78cc6a451989d470d385d4948e"}}, "title": "SARS-CoV-2 Post Vaccinated Adverse Effects and Efficacy in the Egyptian Population.", "authors": [{"family": "Elgendy", "given": "Marwa O", "initials": "MO", "orcid": "0000-0002-5466-0552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/092137ee2845486aa4c0a926a2d4c0a2.json"}}, {"family": "El-Gendy", "given": "Ahmed O", "initials": "AO", "orcid": "0000-0002-0980-5185", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37a05711bd4f4a67bd6af36f6df989e6.json"}}, {"family": "Alzarea", "given": "Abdulaziz Ibrahim", "initials": "AI", "orcid": "0000-0003-0604-6299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb86c921515b4f69b3ee4a9c496ee44e.json"}}, {"family": "Mahmoud", "given": "Sarah", "initials": "S"}, {"family": "Alqahtani", "given": "Saad S", "initials": "SS"}, {"family": "Fahmy", "given": "Alzhraa M", "initials": "AM"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}, {"family": "Sayed", "given": "Ahmed M", "initials": "AM", "orcid": "0000-0002-1442-183X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/013ee0ba73bb4d7f87fd285c65e49725.json"}}, {"family": "Alatawi", "given": "Ahmed D", "initials": "AD"}, {"family": "Abdelrahim", "given": "Mohamed E A", "initials": "MEA", "orcid": "0000-0003-0227-8404", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/feb86f846aee415dac74ef2f455ecb42.json"}}, {"family": "Alanazi", "given": "Abdullah S", "initials": "AS", "orcid": "0000-0002-8120-4018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22f197492bd64d478a6c5ac6072708c6.json"}}], "type": "journal article", "published": "2021-12-24", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "10", "issue": "1", "issn-l": null}, "abstract": "Vaccines are the solution to overcome SARS-CoV-2. This study aimed to determine the post-Sinopharm vaccine safety-profile and immunity through antibody titers. Data were collected using a structured questionnaire from Egyptian participants who received two doses of Sinopharm vaccine. Data were divided into three parts, the first and second parts were to detect participants' post-first and second dose symptoms and practices, and the third for the results of IgG anti spike protein antibodies test and laboratory tests. Pain, redness, swelling at the injection site, headache, fatigue, and lethargy were the most common post-vaccine symptoms for both first and second doses. Most of the participants felt mild or no symptoms after vaccination. The symptoms started mostly during the first day post-vaccination and lasted for no more than two days. Forty-nine percent of the participants resulted in positive antibodies tests on day 18 post-vaccination. The average antibody level for vaccinated participants with past SARS-CoV-2 infection was much higher than that for non-past infected participants. These vaccines' administration methods need to be reevaluated by changing the dose, dose interval, adding a third dose, or mixing it with other vaccines with different techniques to improve their protection rates. Further studies are required to validate this finding.", "doi": "10.3390/vaccines10010018", "pmid": "35062679", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "vaccines10010018"}], "notes": [], "created": "2022-01-26T10:19:21.276Z", "modified": "2022-01-26T10:19:42.647Z"}, {"entity": "publication", "iuid": "a7d9bdf7e3a041e482c3586e9755e774", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7d9bdf7e3a041e482c3586e9755e774.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7d9bdf7e3a041e482c3586e9755e774"}}, "title": "Personal Social Networks of Community-Dwelling Oldest Old During the Covid-19 Pandemic-A Qualitative Study.", "authors": [{"family": "Kulmala", "given": "Jenni", "initials": "J"}, {"family": "Tiilikainen", "given": "Elisa", "initials": "E"}, {"family": "Lisko", "given": "Inna", "initials": "I"}, {"family": "Ngandu", "given": "Tiia", "initials": "T"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Solomon", "given": "Alina", "initials": "A"}], "type": "journal article", "published": "2021-12-24", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "770965", "issn-l": "2296-2565"}, "abstract": "The COVID-19 pandemic and its related restrictions have affected the everyday life of older people. Advanced age is a significant predisposing factor for a more severe COVID-19 infection, increasing the risk for hospitalization and mortality. Even though restrictions have been, thus, well-grounded, they may also have had detrimental effects on the social well-being of older people. Personal networks and social activity are known protective factors against the premature decline in health and functioning, and it is widely acknowledged that social isolation increases feelings of loneliness, poor quality of life, and even the risk for diseases and disabilities among older adults. This qualitative study investigated changes in personal networks among community-dwelling oldest-old individuals (persons aged 80 and over) during the first and second waves of the COVID-19 pandemic in Finland. The data is part of the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE85+) study, which is an ongoing large longitudinal population-based study in Finland. In this qualitative sub-study, we analyzed fifteen in-depth telephone interviews using directed content analyses and identified five types of changes in personal social networks during the pandemic. In type 1, all social contacts were significantly reduced due to official recommendations and fear of the virus. Type 2 included modified ways of being socially active i.e., by deploying new technology, and in type 3, social contacts increased during the lockdown. In type 4, personal social networks were changed unexpectedly or dramatically due to a death of a spouse, for example. In type 5, we observed stable social networks, which had not been affected by the pandemic. At an individual level, one person could have had different types of changes during the pandemic. These results highlight the heterogeneity of the oldest olds' personal social networks and changes related to them during the exceptional times of the COVID-19 pandemic. Social activity and personal networks play an important role in the well-being of the oldest old, but individual situations, needs, and preferences toward personal social networks should be taken into account when planning social activities, policies, and interventions.", "doi": "10.3389/fpubh.2021.770965", "pmid": "35004583", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8739883"}], "notes": [], "created": "2022-01-13T21:10:36.758Z", "modified": "2022-01-13T21:10:36.774Z"}, {"entity": "publication", "iuid": "67e12edf73e84fa38eb02d787339cf33", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/67e12edf73e84fa38eb02d787339cf33.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/67e12edf73e84fa38eb02d787339cf33"}}, "title": "COVID-19 and stillbirth: direct vs indirect effect of the pandemic.", "authors": [{"family": "Khalil", "given": "A", "initials": "A", "orcid": "0000-0003-2802-7670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e4558e368114cfb83c4594f523b38c0.json"}}, {"family": "Blakeway", "given": "H", "initials": "H"}, {"family": "Samara", "given": "A", "initials": "A"}, {"family": "O'Brien", "given": "P", "initials": "P"}], "type": "journal article", "published": "2021-12-24", "journal": {"title": "Ultrasound Obstet Gynecol", "issn": "1469-0705", "issn-l": null}, "abstract": null, "doi": "10.1002/uog.24846", "pmid": "34951732", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:26:30.102Z", "modified": "2022-01-04T15:26:30.156Z"}, {"entity": "publication", "iuid": "0f880ab1d5454514afb4045f0c9a7704", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0f880ab1d5454514afb4045f0c9a7704.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0f880ab1d5454514afb4045f0c9a7704"}}, "title": "Response to Letter to the Editor: Comment on \"Body mass index and Mini Nutritional Assessment-Short Form as predictors of in-geriatric hospital mortality in older adults with COVID-19\" (by Caf\u00e9 Balc\u0131, MD, Hacettepe University Faculty of Medicine Department of Internal Medicine Division of Geriatric Medicine).", "authors": [{"family": "Kananen", "given": "Laura", "initials": "L"}, {"family": "Religa", "given": "Dorota", "initials": "D"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}, {"family": "H\u00e4gg", "given": "Sara", "initials": "S"}, {"family": "Julh\u00e4v\u00e4", "given": "Juulia", "initials": "J"}, {"family": "Cederholm", "given": "Tommy", "initials": "T"}], "type": "letter", "published": "2021-12-23", "journal": {"title": "Clin Nutr", "issn": "1532-1983", "issn-l": null}, "abstract": null, "doi": "10.1016/j.clnu.2021.12.027", "pmid": "35027222", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0261-5614(21)00584-7"}, {"db": "pmc", "key": "PMC8695347"}], "notes": [], "created": "2022-01-27T08:13:47.281Z", "modified": "2022-01-27T08:13:47.286Z"}, {"entity": "publication", "iuid": "5fa87903c2a649fb95e9eba28af4b30b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5fa87903c2a649fb95e9eba28af4b30b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5fa87903c2a649fb95e9eba28af4b30b"}}, "title": "Distance Learning Effects Among Italian Children and Parents During COVID-19 Related School Lockdown.", "authors": [{"family": "Crisci", "given": "Giulia", "initials": "G"}, {"family": "Mammarella", "given": "Irene C", "initials": "IC"}, {"family": "Moscardino", "given": "Ughetta M M", "initials": "UMM"}, {"family": "Roch", "given": "Maja", "initials": "M"}, {"family": "Thorell", "given": "Lisa B", "initials": "LB"}], "type": "journal article", "published": "2021-12-23", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "782353", "issn-l": "1664-0640"}, "abstract": "Background: During the COVID-19 pandemic, both children and their parents experienced consequences related to distance learning (DL). However, positive and negative effects have varied greatly among families, and the specific factors explaining these differences in experiences are still underexplored. In this study, we examined children's executive functions (EF) and parents' psychological well-being in relation to negative and positive effects of DL on both children and their parents. Method: Participants were 637 Italian parents (92% mothers) with a child (48% male) aged between 6 and 19 years involved in DL due to school closures during the first wave of the COVID-19 pandemic. Data were collected using an online survey. We performed three fixed-order hierarchical multiple regression analyses with child age and sex, children's EF deficits, and parents' psychological well-being as independent variables, and DL-related negative effects (on the child and on the parent) and DL-related positive effects as dependent variables. Results: The results of the regression analyses showed that for negative effects of DL, younger age and greater EF deficits explained most part of the variance. Specifically, regarding negative effects on children, the most important factor was EF deficits, whereas regarding negative effects on parents, child age was the most important factor. For positive effects of DL, all variables explained only a small part of the variance. Child age was the most important factor, but EF deficits and parents' psychological well-being also had a significant impact. Conclusions: The effects of DL during school closures vary widely across families. Our findings indicate that intervention efforts need to consider background variables, child factors, as well as parent factors when supporting families with homeschooling in times of pandemic.", "doi": "10.3389/fpsyt.2021.782353", "pmid": "35002803", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8732950"}], "notes": [], "created": "2022-01-13T21:11:22.012Z", "modified": "2022-01-13T21:11:22.026Z"}, {"entity": "publication", "iuid": "f7fc256aa7c44d34ad6da0ab245d9b4e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7fc256aa7c44d34ad6da0ab245d9b4e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7fc256aa7c44d34ad6da0ab245d9b4e"}}, "title": "Androgen deprivation therapy, comorbidity, cancer stage and mortality from COVID-19 in men with prostate cancer.", "authors": [{"family": "Gedeborg", "given": "Rolf", "initials": "R", "orcid": "0000-0002-8850-7863", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/234ef51ed7854efb8bbadc3ce35bf7d9.json"}}, {"family": "Lindhagen", "given": "Lars", "initials": "L"}, {"family": "Loeb", "given": "Stacy", "initials": "S"}, {"family": "Styrke", "given": "Johan", "initials": "J"}, {"family": "Garmo", "given": "Hans", "initials": "H"}, {"family": "Stattin", "given": "P\u00e4r", "initials": "P"}], "type": "journal article", "published": "2021-12-23", "journal": {"title": "Scand J Urol", "issn": "2168-1813", "pages": "1-8", "issn-l": null}, "abstract": "Androgens facilitate entrance of the severe acute respiratory syndrome coronavirus 2 into respiratory epithelial cells, and male sex is associated with a higher risk of death from corona virus disease (COVID-19). Androgen deprivation therapy (ADT) could possibly improve COVID-19 outcomes.\n\nIn a case-control study nested in the Prostate Cancer data Base Sweden (PCBaSe) RAPID 2019, we evaluated the association between ADT and COVID-19 as registered cause of death in men with prostate cancer. Each case was matched to 50 controls by region. We used conditional logistic regression to adjust for confounders and also evaluated potential impact of residual confounding.\n\nWe identified 474 men who died from COVID-19 in March-December 2020. In crude analyses, ADT exposure was associated with an increased risk of COVID-19 death (odds ratio [OR] 5.05, 95% CI: 4.18-6.10); however, the OR was substantially attenuated after adjustment for age, comorbidity, prostate cancer characteristics at diagnosis, recent healthcare use, and indicators of advanced cancer (adjusted OR 1.25, 95% CI: 0.95-1.65). If adjustment has accounted for at least 85% of confounding, then the true effect could be no more than a 5% reduction of the odds for COVID-19 death.\n\nThe increased mortality from COVID-19 in men with prostate cancer treated with ADT was mainly related to high age, comorbidity, and more advanced prostate cancer. There was no evidence to support the hypothesis that ADT is associated with improved COVID-19 outcomes.", "doi": "10.1080/21681805.2021.2019304", "pmid": "34939533", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-03T15:35:02.365Z", "modified": "2022-01-03T15:35:42.285Z"}, {"entity": "publication", "iuid": "5a96c0779f7449aea420f70eef901728", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5a96c0779f7449aea420f70eef901728.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5a96c0779f7449aea420f70eef901728"}}, "title": "What now for Sweden and covid-19?", "authors": [{"family": "Paterlini", "given": "Marta", "initials": "M"}], "type": "journal article", "published": "2021-12-22", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "375", "pages": "n3081", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.n3081", "pmid": "34937690", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2022-01-03T15:33:31.328Z", "modified": "2022-01-03T15:33:31.344Z"}, {"entity": "publication", "iuid": "093ffa468c994870b232e6c8f9da47f6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/093ffa468c994870b232e6c8f9da47f6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/093ffa468c994870b232e6c8f9da47f6"}}, "title": "The Exposome and Immune Health in Times of the COVID-19 Pandemic.", "authors": [{"family": "Morales", "given": "Javier S", "initials": "JS"}, {"family": "Valenzuela", "given": "Pedro L", "initials": "PL", "orcid": "0000-0003-1730-3369", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0526f21ccb3c442085a7e77fd5ff49e9.json"}}, {"family": "Castillo-Garc\u00eda", "given": "Adri\u00e1n", "initials": "A"}, {"family": "Butrague\u00f1o", "given": "Javier", "initials": "J"}, {"family": "Jim\u00e9nez-Pav\u00f3n", "given": "David", "initials": "D", "orcid": "0000-0002-8977-4744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0b7642d758d4e2aa4f69df83a0c2c73.json"}}, {"family": "Carrera-Bastos", "given": "Pedro", "initials": "P"}, {"family": "Lucia", "given": "Alejandro", "initials": "A"}], "type": "journal article", "published": "2021-12-22", "journal": {"title": "Nutrients", "issn": "2072-6643", "volume": "14", "issue": "1", "issn-l": null}, "abstract": "Growing evidence supports the importance of lifestyle and environmental exposures-collectively referred to as the 'exposome'-for ensuring immune health. In this narrative review, we summarize and discuss the effects of the different exposome components (physical activity, body weight management, diet, sun exposure, stress, sleep and circadian rhythms, pollution, smoking, and gut microbiome) on immune function and inflammation, particularly in the context of the current coronavirus disease 2019 (COVID-19) pandemic. We highlight the potential role of 'exposome improvements' in the prevention-or amelioration, once established-of this disease as well as their effect on the response to vaccination. In light of the existing evidence, the promotion of a healthy exposome should be a cornerstone in the prevention and management of the COVID-19 pandemic and other eventual pandemics.", "doi": "10.3390/nu14010024", "pmid": "35010900", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "nu14010024"}], "notes": [], "created": "2022-01-13T21:07:19.748Z", "modified": "2022-01-13T21:07:21.095Z"}, {"entity": "publication", "iuid": "dd739d1768c84ea29a5623e9375eb5ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dd739d1768c84ea29a5623e9375eb5ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dd739d1768c84ea29a5623e9375eb5ca"}}, "title": "SARS-CoV-2 reactive and neutralizing antibodies discovered by single-cell sequencing of plasma cells and mammalian display.", "authors": [{"family": "Ehling", "given": "Roy A", "initials": "RA"}, {"family": "Weber", "given": "C\u00e9dric R", "initials": "CR"}, {"family": "Mason", "given": "Derek M", "initials": "DM"}, {"family": "Friedensohn", "given": "Simon", "initials": "S"}, {"family": "Wagner", "given": "Bastian", "initials": "B"}, {"family": "Bieberich", "given": "Florian", "initials": "F"}, {"family": "Kapetanovic", "given": "Edo", "initials": "E"}, {"family": "Vazquez-Lombardi", "given": "Rodrigo", "initials": "R"}, {"family": "Di Roberto", "given": "Rapha\u00ebl B", "initials": "RB"}, {"family": "Hong", "given": "Kai-Lin", "initials": "KL"}, {"family": "Wagner", "given": "Camille", "initials": "C"}, {"family": "Pataia", "given": "Michele", "initials": "M"}, {"family": "Overath", "given": "Max D", "initials": "MD"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Yermanos", "given": "Alexander", "initials": "A"}, {"family": "Cuny", "given": "Andreas P", "initials": "AP"}, {"family": "Savic", "given": "Miodrag", "initials": "M"}, {"family": "Rudolf", "given": "Fabian", "initials": "F"}, {"family": "Reddy", "given": "Sai T", "initials": "ST"}], "type": "journal article", "published": "2021-12-22", "journal": {"title": "Cell Rep", "issn": "2211-1247", "pages": "110242", "issn-l": null}, "abstract": "Characterization of COVID-19 antibodies has largely focused on memory B cells; however, it is the antibody-secreting plasma cells that are directly responsible for the production of serum antibodies, which play a critical role in resolving SARS-CoV-2 infection. Little is known about the specificity of plasma cells, largely because plasma cells lack surface antibody expression, thereby complicating their screening. Here, we describe a technology pipeline that integrates single-cell antibody repertoire sequencing and mammalian display to interrogate the specificity of plasma cells from 16 convalescent patients. Single-cell sequencing allows us to profile antibody repertoire features and identify expanded clonal lineages. Mammalian display screening is used to reveal that 43 antibodies (of 132 candidates) derived from expanded plasma cell lineages are specific to SARS-CoV-2 antigens, including antibodies with high affinity to the SARS-CoV-2 receptor-binding domain (RBD) that exhibit potent neutralization and broad binding to the RBD of SARS-CoV-2 variants (of concern/interest).", "doi": "10.1016/j.celrep.2021.110242", "pmid": "34998467", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2211-1247(21)01751-4"}, {"db": "URL", "key": "https://github.com/LSSI-ETH", "description": "https://github.com/LSSI-ETH"}, {"db": "URL", "key": "https://dx.doi.org/10.17632/rvd7999gk4.1", "description": "Fully annotated extracted antibody sequences and single cell results"}, {"db": "BioProject", "key": "http://www.ncbi.nlm.nih.gov/bioproject/782883", "description": "http://www.ncbi.nlm.nih.gov/bioproject/782883"}, {"db": "URL", "key": "http://www.ncbi.nlm.nih.gov/bioproject/782992", "description": "http://www.ncbi.nlm.nih.gov/bioproject/782992"}], "notes": [], "created": "2022-01-10T11:52:01.582Z", "modified": "2022-01-10T11:54:42.355Z"}, {"entity": "publication", "iuid": "d06ea09961354e1eb33ebe12c661c146", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d06ea09961354e1eb33ebe12c661c146.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d06ea09961354e1eb33ebe12c661c146"}}, "title": "Characteristics and outcomes of patients with COVID-19 with and without prevalent hypertension: a multinational cohort study.", "authors": [{"family": "Reyes", "given": "Carlen", "initials": "C", "orcid": "0000-0001-8486-3265", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64ac81f77bd340b0a29d97ee85d1f5c8.json"}}, {"family": "Pistillo", "given": "Andrea", "initials": "A"}, {"family": "Fern\u00e1ndez-Bertol\u00edn", "given": "Sergio", "initials": "S"}, {"family": "Recalde", "given": "Martina", "initials": "M"}, {"family": "Roel", "given": "Elena", "initials": "E"}, {"family": "Puente", "given": "Diana", "initials": "D"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Blacketer", "given": "Clair", "initials": "C"}, {"family": "Lai", "given": "Lana", "initials": "L"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Ahmed", "given": "Waheed-Ui-Rahman", "initials": "WU"}, {"family": "Alser", "given": "Osaid", "initials": "O", "orcid": "0000-0001-6743-803X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c919eb8e21f74327b80f25eae0313eb6.json"}}, {"family": "Alghoul", "given": "Heba", "initials": "H", "orcid": "0000-0001-8234-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e3deb1abdf54088a29dee7675a18697.json"}}, {"family": "Areia", "given": "Carlos", "initials": "C", "orcid": "0000-0002-4668-7069", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7232f54be5df43f0b984d0117d88a054.json"}}, {"family": "Dawoud", "given": "Dalia", "initials": "D"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A", "orcid": "0000-0003-1202-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47f086bb6ccd49a2a5f11a32c06277c8.json"}}, {"family": "Valveny", "given": "Neus", "initials": "N"}, {"family": "de Maeztu", "given": "Gabriel", "initials": "G"}, {"family": "Sorl\u00ed Red\u00f3", "given": "Luisa", "initials": "L"}, {"family": "Martinez Roldan", "given": "Jordi", "initials": "J"}, {"family": "Lopez Montesinos", "given": "Inmaculada", "initials": "I"}, {"family": "Schilling", "given": "Lisa M", "initials": "LM"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Shah", "given": "Nigam", "initials": "N"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "DuVall", "given": "Scott L", "initials": "SL"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR", "orcid": "0000-0003-0621-1979", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d03ea51cfd6344d5a6469fef31e9f941.json"}}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Kostka", "given": "Kristin", "initials": "K", "orcid": "0000-0003-2595-8736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9675cf1b775341f6a3521c7dde950262.json"}}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T", "orcid": "0000-0002-8274-0357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11fd8deb257445e7a93a0a3098b246df.json"}}], "type": "journal article", "published": "2021-12-22", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "12", "pages": "e057632", "issn-l": "2044-6055"}, "abstract": "To characterise patients with and without prevalent hypertension and COVID-19 and to assess adverse outcomes in both inpatients and outpatients.\n\nThis is a retrospective cohort study using 15 healthcare databases (primary and secondary electronic healthcare records, insurance and national claims data) from the USA, Europe and South Korea, standardised to the Observational Medical Outcomes Partnership common data model. Data were gathered from 1 March to 31 October 2020.\n\nTwo non-mutually exclusive cohorts were defined: (1) individuals diagnosed with COVID-19 (diagnosed cohort) and (2) individuals hospitalised with COVID-19 (hospitalised cohort), and stratified by hypertension status. Follow-up was from COVID-19 diagnosis/hospitalisation to death, end of the study period or 30 days.\n\nDemographics, comorbidities and 30-day outcomes (hospitalisation and death for the 'diagnosed' cohort and adverse events and death for the 'hospitalised' cohort) were reported.\n\nWe identified 2 851 035 diagnosed and 563 708 hospitalised patients with COVID-19. Hypertension was more prevalent in the latter (ranging across databases from 17.4% (95% CI 17.2 to 17.6) to 61.4% (95% CI 61.0 to 61.8) and from 25.6% (95% CI 24.6 to 26.6) to 85.9% (95% CI 85.2 to 86.6)). Patients in both cohorts with hypertension were predominantly >50 years old and female. Patients with hypertension were frequently diagnosed with obesity, heart disease, dyslipidaemia and diabetes. Compared with patients without hypertension, patients with hypertension in the COVID-19 diagnosed cohort had more hospitalisations (ranging from 1.3% (95% CI 0.4 to 2.2) to 41.1% (95% CI 39.5 to 42.7) vs from 1.4% (95% CI 0.9 to 1.9) to 15.9% (95% CI 14.9 to 16.9)) and increased mortality (ranging from 0.3% (95% CI 0.1 to 0.5) to 18.5% (95% CI 15.7 to 21.3) vs from 0.2% (95% CI 0.2 to 0.2) to 11.8% (95% CI 10.8 to 12.8)). Patients in the COVID-19 hospitalised cohort with hypertension were more likely to have acute respiratory distress syndrome (ranging from 0.1% (95% CI 0.0 to 0.2) to 65.6% (95% CI 62.5 to 68.7) vs from 0.1% (95% CI 0.0 to 0.2) to 54.7% (95% CI 50.5 to 58.9)), arrhythmia (ranging from 0.5% (95% CI 0.3 to 0.7) to 45.8% (95% CI 42.6 to 49.0) vs from 0.4% (95% CI 0.3 to 0.5) to 36.8% (95% CI 32.7 to 40.9)) and increased mortality (ranging from 1.8% (95% CI 0.4 to 3.2) to 25.1% (95% CI 23.0 to 27.2) vs from 0.7% (95% CI 0.5 to 0.9) to 10.9% (95% CI 10.4 to 11.4)) than patients without hypertension.\n\nCOVID-19 patients with hypertension were more likely to suffer severe outcomes, hospitalisations and deaths compared with those without hypertension.", "doi": "10.1136/bmjopen-2021-057632", "pmid": "34937726", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-057632"}, {"db": "pmc", "key": "PMC8704062"}], "notes": [], "created": "2022-01-03T15:34:18.912Z", "modified": "2022-01-03T15:34:32.723Z"}, {"entity": "publication", "iuid": "87c62cac7b124fa7a08738b66eae598f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87c62cac7b124fa7a08738b66eae598f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87c62cac7b124fa7a08738b66eae598f"}}, "title": "Plasma Leptin Is Increased in Intensive Care Patients with COVID-19-An Investigation Performed in the PronMed-Cohort.", "authors": [{"family": "Larsson", "given": "Anders", "initials": "A", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2be858ab604743b72383dfdcd14689.json"}}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Eriksson", "given": "Mats", "initials": "M", "orcid": "0000-0002-3178-4210", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c90375295094966a51f9d17c275abb6.json"}}], "type": "journal article", "published": "2021-12-21", "journal": {"title": "Biomedicines", "issn": "2227-9059", "issn-l": null, "volume": "10", "issue": "1", "pages": null}, "abstract": "COVID-19 has shaken the world and intensive care units (ICU) have been challenged by numerous patients suffering from a previously unknown disease. Leptin is a polypeptide pleiotropic hormone, mainly expressed by adipocytes. It acts as a proinflammatory cytokine and is associated with several conditions, known to increase the risk of severe COVID-19. Very little is known about leptin in severe viral disorders. Plasma leptin was analyzed in 222 out of 229 patients with severe COVID-19 on admission to an ICU at Uppsala University Hospital, a tertiary care hospital in Sweden, and compared to plasma leptin in 25 healthy blood donors. COVID-19 was confirmed by positive PCR. Leptin levels were significantly higher in patients with COVID-19 (18.3 ng \u00d7 mL-1; IQR = 30.4), than in healthy controls (7.8 ng \u00d7 mL-1; IQR = 6.4). Women had significantly higher leptin values (22.9 ng \u00d7 mL-1; IQR = 29.8) than men (17.5 ng \u00d7 mL-1; IQR = 29.9). Mortality at 30 days was 23% but was not associated with increased leptin levels. Neither median duration of COVID-19 before admission to ICU (10 days; IQR = 4) or median length of ICU stay (8 days; IQR = 11) correlated with the plasma leptin levels. Leptin levels in COVID-19 were higher in females than in males. Both treatment (e.g., use of corticosteroids) and prophylaxis (vaccines) have been improved since the start of the COVID-19 pandemic, which may contribute to some difficulties in deciphering relations between COVID-19 and leptin.", "doi": "10.3390/biomedicines10010004", "pmid": "35052684", "labels": {"Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Biochemistry": null, "Funder: VR": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "biomedicines10010004"}], "notes": [], "created": "2022-01-26T10:22:24.166Z", "modified": "2022-02-08T19:22:23.653Z"}, {"entity": "publication", "iuid": "ef350c9ac7a04e84bc75cd86b285cc1e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef350c9ac7a04e84bc75cd86b285cc1e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef350c9ac7a04e84bc75cd86b285cc1e"}}, "title": "Considerations for COVID-19 management in reception centers for refugees, asylum seekers and migrants, Spain 2020.", "authors": [{"family": "Hoefer", "given": "Andreas", "initials": "A"}, {"family": "Pampaka", "given": "Despina", "initials": "D"}, {"family": "Castrillejo", "given": "Daniel", "initials": "D"}, {"family": "Luenga-Cabrera", "given": "Jos\u00e9", "initials": "J"}, {"family": "Paisi", "given": "Martha", "initials": "M"}, {"family": "Herrera-Le\u00f3n", "given": "Silvia", "initials": "S"}, {"family": "L\u00f3pez-Perea", "given": "Noem\u00ed", "initials": "N"}, {"family": "Del Diego-Salas", "given": "Jorge", "initials": "J"}], "type": "journal article", "published": "2021-12-21", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": null, "issue": null, "pages": null}, "abstract": "Shortly after the declaration of the COVID-19 pandemic, governments around the world were urged to leave no population behind. Following a COVID-19 risk evaluation in a refugee and asylum seekers reception center, in September 2020, we considered the priorities of managing COVID-19 in these settings. We encourage actions on four fronts to reduce the COVID-19 associated burden amongst these vulnerable populations based on our interviews, observations and recommendations: (i) decongestion, (ii) facilitated testing, (iii) screening for symptoms and (iv) targeted public health and risk communication.", "doi": "10.1016/j.ijid.2021.12.341", "pmid": "34952212", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)01240-6"}, {"db": "pmc", "key": "PMC8690219"}], "notes": [], "created": "2022-01-04T15:26:01.536Z", "modified": "2022-11-22T05:43:02.433Z"}, {"entity": "publication", "iuid": "1366fc55cc6947d495356d3d29942458", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1366fc55cc6947d495356d3d29942458.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1366fc55cc6947d495356d3d29942458"}}, "title": "Chaplain Leadership During COVID-19: An International Expert Panel.", "authors": [{"family": "Szilagyi", "given": "Csaba", "initials": "C", "orcid": "0000-0002-0413-3025", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d833cb5acf3f432395c8b03de5554f81.json"}}, {"family": "Vandenhoeck", "given": "Anne", "initials": "A", "orcid": "0000-0003-0479-6408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d02323e639d4c38acbe70795fe2f6db.json"}}, {"family": "Best", "given": "Megan C", "initials": "MC"}, {"family": "Desjardins", "given": "Cate Michelle", "initials": "CM", "orcid": "0000-0002-7928-3239", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c98b6cd4026249cdaffd63d17cf0d302.json"}}, {"family": "Drummond", "given": "David A", "initials": "DA"}, {"family": "Fitchett", "given": "George", "initials": "G"}, {"family": "Harrison", "given": "Simon", "initials": "S"}, {"family": "Haythorn", "given": "Trace", "initials": "T", "orcid": "0000-0001-7681-6522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/018d1123ea7c4a5e9b4886eb4a1052ab.json"}}, {"family": "Holmes", "given": "Cheryl", "initials": "C"}, {"family": "Muthert", "given": "Hanneke", "initials": "H", "orcid": "0000-0002-1975-6102", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2442aa919afa40669626e7f91ae961d8.json"}}, {"family": "Nuzum", "given": "Daniel", "initials": "D", "orcid": "0000-0002-9907-5680", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ef033373aa741dfab63209ec5238ff9.json"}}, {"family": "Verhoef", "given": "Joost H A", "initials": "JHA"}, {"family": "Willander", "given": "Erika", "initials": "E"}], "type": "journal article", "published": "2021-12-21", "journal": {"title": "J Pastoral Care Counsel", "issn": "2167-776X", "pages": "15423050211067724", "issn-l": null}, "abstract": "Chaplain leadership may have played a pivotal role in shaping chaplains' roles in health care amidst the COVID-19 pandemic. We convened an international expert panel to identify expert perception on key chaplain leadership factors. Six leadership themes of professional confidence, engaging and trust-building with executives, decision-making, innovation and creativity, building integrative and trusting connections with colleagues, and promoting cultural competencies emerged as central to determining chaplains' integration, perceived value, and contributions during the pandemic.", "doi": "10.1177/15423050211067724", "pmid": "34931932", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-03T15:30:43.220Z", "modified": "2022-01-03T15:30:43.448Z"}, {"entity": "publication", "iuid": "9bec6670580f4b5ebfa595be1ce83f4a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9bec6670580f4b5ebfa595be1ce83f4a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9bec6670580f4b5ebfa595be1ce83f4a"}}, "title": "The COVID-19 pandemic as experienced by adults with congenital heart disease from Belgium, Norway, and South Korea: impact on life domains, patient-reported outcomes, and experiences with care.", "authors": [{"family": "Moons", "given": "Philip", "initials": "P", "orcid": "0000-0002-8609-4516", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c7081af91424589a389e04745224849.json"}}, {"family": "Goossens", "given": "Eva", "initials": "E", "orcid": "0000-0003-3421-5256", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3869f53db0f542ac9c1ddf2a2527d2dc.json"}}, {"family": "Luyckx", "given": "Koen", "initials": "K", "orcid": "0000-0001-8862-5598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/794e7a8d0d2f4ead85fffcb95e054be4.json"}}, {"family": "Kovacs", "given": "Adrienne H", "initials": "AH", "orcid": "0000-0002-2687-0384", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/efc671a612194680a5db5e0bf04cf1d9.json"}}, {"family": "Andresen", "given": "Brith", "initials": "B", "orcid": "0000-0003-4359-9757", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/127245033cae4fc59d8eaeb693b52064.json"}}, {"family": "Moon", "given": "Ju Ryoung", "initials": "JR", "orcid": "0000-0002-4285-0295", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f415f05186a4935bc3ddc3de52059f9.json"}}, {"family": "Van De Bruaene", "given": "Alexander", "initials": "A", "orcid": "0000-0002-0469-8640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/603e48f2c9284953a674b3bae0392d1d.json"}}, {"family": "Rassart", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8535-1499", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d560e6e869849f6a9a8b23cb6765795.json"}}, {"family": "Van Bulck", "given": "Liesbet", "initials": "L", "orcid": "0000-0001-8975-4455", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bfadcaac546b4a818af2651cef4d0973.json"}}, {"family": "APPROACH-IS II consortium and ISACHD\n", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-20", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "issn-l": null}, "abstract": "The coronavirus disease-2019 (COVID-19) pandemic poses significant challenges to many groups within societies, and especially for people with chronic health conditions. It is, however, unknown whether and how the pandemic has thus far affected the physical and mental health of patient populations. Therefore, we investigated how the pandemic affected the lives of adults with congenital heart disease (CHD), compared pre- and peri-pandemic patient-reported outcome measures (PROMs) and a patient-reported experience measure (PREM), and investigated whether having had COVID-19 impacted pre-/peri-pandemic differences of the PROMs and PREM.\n\nAs part of the ongoing APPROACH-IS II project, we longitudinally surveyed 716 adults with CHD from Belgium, Norway, and South Korea. Pre-pandemic measures were administered from August 2019 to February 2020 and the peri-pandemic surveys were completed September 2020-April 2021. The majority of patients indicated that their social lives (80%), mental health (58%), and professional lives/education (51%) were negatively impacted by the pandemic. Patients felt worried (65%), were afraid (55%), reported the pandemic felt 'close' to them (53%), and were stressed (52%). However, differences between pre- and peri-pandemic scores on the PROMs and PREM were negligibly small (Cohen's d < 0.20). Across measures, 5.8-15.8% of patients demonstrated changes (improved or worsened scores) that exceeded the minimal clinically important difference. There were no difference-in-differences for PROMs and PREM between patients who did vs. did not have COVID-19.\n\nAlthough the COVID-19 pandemic has been disruptive in many ways, pre- to peri-pandemic changes in PROMs and PREM of adults with CHD were negligibly small.", "doi": "10.1093/eurjcn/zvab120", "pmid": "34927192", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6470369"}], "notes": [], "created": "2022-01-03T15:26:00.354Z", "modified": "2022-01-03T15:26:00.655Z"}, {"entity": "publication", "iuid": "741cface6f554bdfb3637d2cb1c2f4c7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/741cface6f554bdfb3637d2cb1c2f4c7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/741cface6f554bdfb3637d2cb1c2f4c7"}}, "title": "Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor.", "authors": [{"family": "Capraz", "given": "T\u00fcmay", "initials": "T", "orcid": "0000-0002-2547-067X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/16b4b4685c774fa394868d772e33e1a0.json"}}, {"family": "Kienzl", "given": "Nikolaus F", "initials": "NF", "orcid": "0000-0001-8057-3930", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00ccebd4f3c34f38b227a2ad414f9dfb.json"}}, {"family": "Laurent", "given": "Elisabeth", "initials": "E", "orcid": "0000-0002-5234-5524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a18c078a3654424b48790ac3409a684.json"}}, {"family": "Perthold", "given": "Jan W", "initials": "JW", "orcid": "0000-0002-8575-0278", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a40db3855af4c39ae1958e99072117a.json"}}, {"family": "F\u00f6derl-H\u00f6benreich", "given": "Esther", "initials": "E", "orcid": "0000-0003-2066-1036", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a769b59ed6e74abca396b6bb69461548.json"}}, {"family": "Gr\u00fcnwald-Gruber", "given": "Clemens", "initials": "C", "orcid": "0000-0002-6097-8348", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/065d1d48a41b4bd6ae83d28277037bea.json"}}, {"family": "Maresch", "given": "Daniel", "initials": "D"}, {"family": "Monteil", "given": "Vanessa", "initials": "V", "orcid": "0000-0002-2652-5695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8ba8a0b1af6423b9cba0fc4bb3177cd.json"}}, {"family": "Niederh\u00f6fer", "given": "Janine", "initials": "J"}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G", "orcid": "0000-0001-7035-7038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70afca1611904e419eca43bde2d681be.json"}}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Zatloukal", "given": "Kurt", "initials": "K", "orcid": "0000-0001-5299-7218", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6a34a836db947d0a327f197a5f938fb.json"}}, {"family": "Mach", "given": "Lukas", "initials": "L", "orcid": "0000-0001-9013-5408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e58ab479be1e4abd9f95f0c5737f280b.json"}}, {"family": "Penninger", "given": "Josef M", "initials": "JM", "orcid": "0000-0002-8194-3777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e56aaa008524272bf252df804e06991.json"}}, {"family": "Oostenbrink", "given": "Chris", "initials": "C", "orcid": "0000-0002-4232-2556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37566a0341cf4fd38366e43218cffd23.json"}}, {"family": "Stadlmann", "given": "Johannes", "initials": "J", "orcid": "0000-0001-5693-6690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab12a13b3ddd442588c1c9bda683d9ee.json"}}], "type": "journal article", "published": "2021-12-20", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "10", "issn-l": null}, "abstract": "Infection and viral entry of SARS-CoV-2 crucially depends on the binding of its Spike protein to angiotensin converting enzyme 2 (ACE2) presented on host cells. Glycosylation of both proteins is critical for this interaction. Recombinant soluble human ACE2 can neutralize SARS-CoV-2 and is currently undergoing clinical tests for the treatment of COVID-19. We used 3D structural models and molecular dynamics simulations to define the ACE2 N-glycans that critically influence Spike-ACE2 complex formation. Engineering of ACE2 N-glycosylation by site-directed mutagenesis or glycosidase treatment resulted in enhanced binding affinities and improved virus neutralization without notable deleterious effects on the structural stability and catalytic activity of the protein. Importantly, simultaneous removal of all accessible N-glycans from recombinant soluble human ACE2 yields a superior SARS-CoV-2 decoy receptor with promise as effective treatment for COVID-19 patients.", "doi": "10.7554/eLife.73641", "pmid": "34927585", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8730730"}, {"db": "pii", "key": "73641"}], "notes": [], "created": "2022-01-03T15:26:30.313Z", "modified": "2023-06-19T14:37:25.873Z"}, {"entity": "publication", "iuid": "b5b248ae72da40448398da21a0a9cf85", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5b248ae72da40448398da21a0a9cf85.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5b248ae72da40448398da21a0a9cf85"}}, "title": "Immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in older residents of a long-term care facility: relation with age, frailty and prior infection status.", "authors": [{"family": "Seiffert", "given": "Piotr", "initials": "P", "orcid": "0000-0001-7987-5640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3350920951f422eac0c2667c7aae4c9.json"}}, {"family": "Konka", "given": "Adam", "initials": "A"}, {"family": "Kasperczyk", "given": "Janusz", "initials": "J", "orcid": "0000-0002-6945-1200", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f0d95aa2fe1446bafb2ed67696b4146.json"}}, {"family": "Kawa", "given": "Jacek", "initials": "J", "orcid": "0000-0002-2804-7885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4126c74290704df495c610f0b5646d97.json"}}, {"family": "Lejawa", "given": "Mateusz", "initials": "M", "orcid": "0000-0002-1228-7534", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e36f837cd6054b2592d7b7d5dbd57a03.json"}}, {"family": "Ma\u015blanka-Seiffert", "given": "Barbara", "initials": "B", "orcid": "0000-0002-5524-0760", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2529abd1474e49d295c477ffeb767c36.json"}}, {"family": "Zembala-John", "given": "Joanna", "initials": "J", "orcid": "0000-0001-5787-3820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91acb29e031941d6b33a968d7e57cb3e.json"}}, {"family": "Bugdol", "given": "Monika", "initials": "M", "orcid": "0000-0002-6917-0441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/38995f1aae584d2182028ef11a89da3a.json"}}, {"family": "Romanik", "given": "Ma\u0142gorzata", "initials": "M", "orcid": "0000-0003-0377-9833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a748240d8bd48b5a126909ab565022d.json"}}, {"family": "Bu\u0142dak", "given": "Rafa\u0142", "initials": "R", "orcid": "0000-0002-0405-0596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44aad3c48a484fd1bf10681a361b795d.json"}}, {"family": "Marcisz", "given": "Czes\u0142aw", "initials": "C", "orcid": "0000-0001-9313-1007", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed63975fc6ca41e89b876d4df2408df3.json"}}, {"family": "Derejczyk", "given": "Jaros\u0142aw", "initials": "J"}, {"family": "Religa", "given": "Dorota", "initials": "D", "orcid": "0000-0003-4583-4570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e2c968ecffa4c638126d6d8d4a0dbd9.json"}}], "type": "journal article", "published": "2021-12-19", "journal": {"title": "Biogerontology", "issn": "1573-6768", "issn-l": null}, "abstract": "Clinical and biological assessment of the COVID-19 vaccine efficacy in the frail population is of crucial importance. The study focuses on measuring the levels of anti-SARS-CoV-2 IgG antibodies before and after BNT162b2 mRNA COVID-19 vaccination among long-term care facility (LTCF) elderly residents. We conducted a prospective, single-center, observational study among LTCF residents. The study protocol was based on three blood sample acquisitions: first taken at baseline-5 days before the first dose of the vaccine, second-20 days after the first dose, and third-12 days after the second shot of the vaccine. The comparison was made for two cohorts: patients with and without prior COVID-19 infection. The data was collected from January to March 2021. A total number of 78 LTCF residents (55 women and 23 men) aged 62-104, 85.72 \u00b1 7.59 years (mean \u00b1 SD), were enrolled in the study. All study participants were investigated for the presence of SARS-CoV-2 anti-spike (S) protein IgG, using a chemiluminescent immunoassay. Frailty was assessed with the Clinical Frailty Scale. Among elderly COVID-19 survivors in LTCF, a single dose of vaccine significantly increased anti-SARS-CoV-2 IgG antibody levels. IgG concentration after a single and double dose was comparable, which may suggest that elderly COVID-19 survivors do not require a second dose of vaccine. For residents without a previous history of COVID-19, two doses are needed to achieve an effective serological response. The level of anti-SARS-CoV-2 IgG antibodies after vaccination with BNT162b2 mRNA COVID-19 did not correlate with the frailty and age of the studied individuals.", "doi": "10.1007/s10522-021-09944-9", "pmid": "34923608", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10522-021-09944-9"}], "notes": [], "created": "2021-12-20T08:32:52.960Z", "modified": "2021-12-20T08:32:53.315Z"}, {"entity": "publication", "iuid": "625ae786f98c4461aea160f935df1fb6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/625ae786f98c4461aea160f935df1fb6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/625ae786f98c4461aea160f935df1fb6"}}, "title": "The impact of COVID-19 on oncology professionals-one year on: lessons learned from the ESMO Resilience Task Force survey series.", "authors": [{"family": "Lim", "given": "K H J", "initials": "KHJ"}, {"family": "Murali", "given": "K", "initials": "K"}, {"family": "Thorne", "given": "E", "initials": "E"}, {"family": "Punie", "given": "K", "initials": "K"}, {"family": "Kamposioras", "given": "K", "initials": "K"}, {"family": "Oing", "given": "C", "initials": "C"}, {"family": "O'Connor", "given": "M", "initials": "M"}, {"family": "\u00c9lez", "given": "E", "initials": "E"}, {"family": "Amaral", "given": "T", "initials": "T"}, {"family": "Garrido", "given": "P", "initials": "P"}, {"family": "Lambertini", "given": "M", "initials": "M"}, {"family": "Devnani", "given": "B", "initials": "B"}, {"family": "Westphalen", "given": "C B", "initials": "CB"}, {"family": "Morgan", "given": "G", "initials": "G"}, {"family": "Haanen", "given": "J B A G", "initials": "JBAG"}, {"family": "Hardy", "given": "C", "initials": "C"}, {"family": "Banerjee", "given": "S", "initials": "S"}], "type": "journal article", "published": "2021-12-17", "journal": {"title": "ESMO Open", "issn": "2059-7029", "volume": "7", "issue": "1", "pages": "100374", "issn-l": null}, "abstract": "COVID-19 has had a significant impact on the well-being and job performance of oncology professionals globally. The European Society for Medical Oncology (ESMO) Resilience Task Force collaboration set out to investigate and monitor well-being since COVID-19 in relation to work, lifestyle and support factors in oncology professionals 1 year on since the start of the pandemic.\n\nAn online, anonymous survey was conducted in February/March 2021 (Survey III). Key outcome variables included risk of poor well-being or distress (expanded Well-Being Index), feeling burnout (single item from expanded Well-Being Index), and job performance since COVID-19. Longitudinal analysis of responses to the series of three surveys since COVID-19 was carried out, and responses to job demands and resources questions were interrogated. SPSS V.26.0/V.27.0 and GraphPad Prism V9.0 were used for statistical analyses.\n\nResponses from 1269 participants from 104 countries were analysed in Survey III: 55% (n = 699/1269) female, 54% (n = 686/1269) >40 years, and 69% (n = 852/1230) of white ethnicity. There continues to be an increased risk of poor well-being or distress (n = 464/1169, 40%) and feeling burnout (n = 660/1169, 57%) compared with Survey I (25% and 38% respectively, P < 0.0001), despite improved job performance. Compared with the initial period of the pandemic, more participants report feeling overwhelmed with workload (45% versus 29%, P < 0.0001). There remain concerns about the negative impact of the pandemic on career development/training (43%), job security (37%). and international fellowship opportunities (76%). Alarmingly, 25% (n = 266/1086) are considering changing their future career with 38% (n = 100/266) contemplating leaving the profession.\n\nOncology professionals continue to face increased job demands. There is now significant concern regarding potential attrition in the oncology workforce. National and international stakeholders must act immediately and work closely with oncology professionals to draw up future-proof recovery plans.", "doi": "10.1016/j.esmoop.2021.100374", "pmid": "35007996", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2059-7029(21)00336-7"}, {"db": "pmc", "key": "PMC8677468"}], "notes": [], "created": "2022-01-13T21:09:07.089Z", "modified": "2022-01-13T21:09:07.104Z"}, {"entity": "publication", "iuid": "fe20006bef944898a5ba6fb7a08430f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fe20006bef944898a5ba6fb7a08430f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fe20006bef944898a5ba6fb7a08430f8"}}, "title": "Predicting regional COVID-19 hospital admissions in Sweden using mobility data.", "authors": [{"family": "Gerlee", "given": "Philip", "initials": "P", "orcid": "0000-0001-8503-0177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ba426c1ab741e781d2b9cd09a0b830.json"}}, {"family": "Karlsson", "given": "Julia", "initials": "J"}, {"family": "Fritzell", "given": "Ingrid", "initials": "I"}, {"family": "Brezicka", "given": "Thomas", "initials": "T"}, {"family": "Spreco", "given": "Armin", "initials": "A"}, {"family": "Timpka", "given": "Toomas", "initials": "T"}, {"family": "J\u00f6ud", "given": "Anna", "initials": "A", "orcid": "0000-0001-7192-4911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e038a5ce2f5a47bd89e7c221651a3d24.json"}}, {"family": "Lundh", "given": "Torbj\u00f6rn", "initials": "T"}], "type": "journal article", "published": "2021-12-17", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "24171", "issn-l": "2045-2322"}, "abstract": "The transmission of COVID-19 is dependent on social mixing, the basic rate of which varies with sociodemographic, cultural, and geographic factors. Alterations in social mixing and subsequent changes in transmission dynamics eventually affect hospital admissions. We employ these observations to model and predict regional hospital admissions in Sweden during the COVID-19 pandemic. We use an SEIR-model for each region in Sweden in which the social mixing is assumed to depend on mobility data from public transport utilisation and locations for mobile phone usage. The results show that the model could capture the timing of the first and beginning of the second wave of the pandemic 3 weeks in advance without any additional assumptions about seasonality. Further, we show that for two major regions of Sweden, models with public transport data outperform models using mobile phone usage. We conclude that a model based on routinely collected mobility data makes it possible to predict future hospital admissions for COVID-19 3 weeks in advance.", "doi": "10.1038/s41598-021-03499-y", "pmid": "34921175", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8683437"}, {"db": "pii", "key": "10.1038/s41598-021-03499-y"}], "notes": [], "created": "2021-12-20T08:33:34.441Z", "modified": "2023-06-19T14:58:56.449Z"}, {"entity": "publication", "iuid": "c1d3881f25114bf690e10d021c077a59", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1d3881f25114bf690e10d021c077a59.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1d3881f25114bf690e10d021c077a59"}}, "title": "Potential SARS-CoV-2 infectiousness among asymptomatic healthcare workers.", "authors": [{"family": "Pimenoff", "given": "Ville N", "initials": "VN", "orcid": "0000-0002-0813-7031", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6df74f265514d7b8fa216d9bad0ead6.json"}}, {"family": "Elfstr\u00f6m", "given": "Miriam", "initials": "M"}, {"family": "Conneryd Lundgren", "given": "Kalle", "initials": "K"}, {"family": "Klevebro", "given": "Susanna", "initials": "S", "orcid": "0000-0002-1261-6502", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e192d615f8648c0ae28b5ccaf1d6803.json"}}, {"family": "Melen", "given": "Erik", "initials": "E"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}], "type": "journal article", "published": "2021-12-17", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "12", "pages": "e0260453", "issn-l": "1932-6203"}, "abstract": "A majority of SARS-CoV-2 infections are transmitted from a minority of infected subjects, some of which may be symptomatic or pre-symptomatic. We aimed to quantify potential infectiousness among asymptomatic healthcare workers (HCWs) in relation to prior or later symptomatic disease. We previously (at the onset of the SARS-CoV-2 epidemic) performed a cohort study of SARS-CoV-2 infections among 27,000 healthcare workers (HCWs) at work in the capital region of Sweden. We performed both SARS-CoV-2 RT-PCR and serology. Furthermore, the cohort was comprehensively followed for sick leave, both before and after sampling. In the present report, we used the cohort database to quantify potential infectiousness among HCWs at work. Those who had sick leave either before or after sampling were classified as post-symptomatic or pre-symptomatic, whereas the virus-positive subjects with no sick leave were considered asymptomatic. About 0.2% (19/9449) of HCW at work were potentially infectious and pre-symptomatic (later had disease) and 0.17% (16/9449) were potentially infectious and asymptomatic (never had sick leave either before nor after sampling). Thus, 33% and 28% of all the 57 potentially infectious subjects were pre-symptomatic or asymptomatic, respectively. When a questionnaire was administered to HCWs with past infection, only 10,5% of HCWs had had no indication at all of having had SARS-CoV-2 infection (\"truly asymptomatic\"). Our findings provide a unique quantification of the different groups of asymptomatic, potentially infectious HCWs.", "doi": "10.1371/journal.pone.0260453", "pmid": "34919570", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-25144"}, {"db": "URL", "key": "https://doi.org/10.1371/journal.pone.0260453.s001", "description": "https://doi.org/10.1371/journal.pone.0260453.s001"}], "notes": [], "created": "2021-12-18T17:37:11.654Z", "modified": "2021-12-18T17:40:54.884Z"}, {"entity": "publication", "iuid": "92fce9aeea0f4e6d8dde3d2c05f4f4f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/92fce9aeea0f4e6d8dde3d2c05f4f4f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/92fce9aeea0f4e6d8dde3d2c05f4f4f2"}}, "title": "Nuclear receptors: from molecular mechanisms to therapeutics.", "authors": [{"family": "Frigo", "given": "Daniel E", "initials": "DE", "orcid": "0000-0002-0713-471X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9838d42de57e4631b568c08cb22415cb.json"}}, {"family": "Bondesson", "given": "Maria", "initials": "M"}, {"family": "Williams", "given": "Cecilia", "initials": "C"}], "type": "editorial", "published": "2021-12-17", "journal": {"title": "Essays Biochem", "issn": "1744-1358", "volume": "65", "issue": "6", "pages": "847-856", "issn-l": null}, "abstract": "Nuclear receptors are classically defined as ligand-activated transcription factors that regulate key functions in reproduction, development, and physiology. Humans have 48 nuclear receptors, which when dysregulated are often linked to diseases. Because most nuclear receptors can be selectively activated or inactivated by small molecules, they are prominent therapeutic targets. The basic understanding of this family of transcription factors was accelerated in the 1980s upon the cloning of the first hormone receptors. During the next 20 years, a deep understanding of hormone signaling was achieved that has translated to numerous clinical applications, such as the development of standard-of-care endocrine therapies for hormonally driven breast and prostate cancers. A 2004 issue of this journal reviewed progress on elucidating the structures of nuclear receptors and their mechanisms of action. In the current issue, we focus on the broad application of new knowledge in this field for therapy across diverse disease states including cancer, cardiovascular disease, various inflammatory diseases, the aging brain, and COVID-19.", "doi": "10.1042/EBC20210020", "pmid": "34825698", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "230306"}, {"db": "pmc", "key": "PMC8628184"}], "notes": [], "created": "2021-12-18T18:18:28.799Z", "modified": "2021-12-18T18:18:28.866Z"}, {"entity": "publication", "iuid": "5c11ae1352184b6f8745bef1b04f1249", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c11ae1352184b6f8745bef1b04f1249.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c11ae1352184b6f8745bef1b04f1249"}}, "title": "Fluvastatin mitigates SARS-CoV-2 infection in human lung cells.", "authors": [{"family": "Zapatero-Belinch\u00f3n", "given": "Francisco J", "initials": "FJ"}, {"family": "Moeller", "given": "Rebecca", "initials": "R"}, {"family": "Lasswitz", "given": "Lisa", "initials": "L"}, {"family": "van Ham", "given": "Marco", "initials": "M"}, {"family": "Becker", "given": "Miriam", "initials": "M"}, {"family": "Brogden", "given": "Graham", "initials": "G"}, {"family": "Rosendal", "given": "Ebba", "initials": "E"}, {"family": "Bi", "given": "Wenjie", "initials": "W"}, {"family": "Carriqu\u00ed-Madro\u00f1al", "given": "Bel\u00e9n", "initials": "B"}, {"family": "Islam", "given": "Koushikul", "initials": "K"}, {"family": "Lenman", "given": "Annasara", "initials": "A"}, {"family": "Gunesch", "given": "Antonia P", "initials": "AP"}, {"family": "Kirui", "given": "Jared", "initials": "J"}, {"family": "Pietschmann", "given": "Thomas", "initials": "T"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "J\u00e4nsch", "given": "Lothar", "initials": "L"}, {"family": "Gerold", "given": "Gisa", "initials": "G"}], "type": "journal article", "published": "2021-12-17", "journal": {"title": "iScience", "issn": "2589-0042", "issn-l": "2589-0042", "volume": "24", "issue": "12", "pages": "103469"}, "abstract": "Clinical data of patients suffering from COVID-19 indicates that statin therapy, used to treat hypercholesterolemia, is associated with a better disease outcome. Whether statins directly affect virus replication or influence the clinical outcome through modulation of immune responses is unknown. We therefore investigated the effect of statins on SARS-CoV-2 infection in human lung cells and found that only fluvastatin inhibited low and high pathogenic coronaviruses in vitro and ex vivo in a dose-dependent manner. Quantitative proteomics revealed that fluvastatin and other tested statins modulated the cholesterol synthesis pathway without altering innate antiviral immune responses in infected lung epithelial cells. However, fluvastatin treatment specifically downregulated proteins that modulate protein translation and viral replication. Collectively, these results support the notion that statin therapy poses no additional risk to individuals exposed to SARS-CoV-2 and that fluvastatin has a moderate beneficial effect on SARS-CoV-2 infection of human lung cells.", "doi": "10.1016/j.isci.2021.103469", "pmid": "34812415", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(21)01440-1"}, {"db": "pmc", "key": "PMC8599137"}], "notes": [], "created": "2021-11-26T13:23:20.647Z", "modified": "2022-02-08T19:22:50.309Z"}, {"entity": "publication", "iuid": "4eceb96b17c1499e9310bdcc0f425bc2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4eceb96b17c1499e9310bdcc0f425bc2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4eceb96b17c1499e9310bdcc0f425bc2"}}, "title": "Differential Effect of SARS-CoV-2 Spike Glycoprotein 1 on Human Bronchial and Alveolar Lung Mucosa Models: Implications for Pathogenicity.", "authors": [{"family": "Rahman", "given": "Mizanur", "initials": "M"}, {"family": "Irmler", "given": "Martin", "initials": "M"}, {"family": "Keshavan", "given": "Sandeep", "initials": "S", "orcid": "0000-0002-2403-4083", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ada27ca05f7448838ea73da4e78220a6.json"}}, {"family": "Introna", "given": "Micol", "initials": "M", "orcid": "0000-0002-5564-1994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f3b999bbb7a4a19969f3ee84273091a.json"}}, {"family": "Beckers", "given": "Johannes", "initials": "J", "orcid": "0000-0002-1038-7160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9add2aa14db44646a7be17d450c14da0.json"}}, {"family": "Palmberg", "given": "Lena", "initials": "L"}, {"family": "Johanson", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8759-9567", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb124bc8baaf4bf8a811a2ffa0abdf0d.json"}}, {"family": "Ganguly", "given": "Koustav", "initials": "K", "orcid": "0000-0001-8531-8154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58b2e0d7853a4b32920e54042e95061d.json"}}, {"family": "Upadhyay", "given": "Swapna", "initials": "S"}], "type": "journal article", "published": "2021-12-17", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "13", "issue": "12", "pages": null}, "abstract": "The SARS-CoV-2 spike protein mediates attachment of the virus to the host cell receptor and fusion between the virus and the cell membrane. The S1 subunit of the spike glycoprotein (S1 protein) contains the angiotensin converting enzyme 2 (ACE2) receptor binding domain. The SARS-CoV-2 variants of concern contain mutations in the S1 subunit. The spike protein is the primary target of neutralizing antibodies generated following infection, and constitutes the viral component of mRNA-based COVID-19 vaccines.\r\n\r\nTherefore, in this work we assessed the effect of exposure (24 h) to 10 nM SARS-CoV-2 recombinant S1 protein on physiologically relevant human bronchial (bro) and alveolar (alv) lung mucosa models cultured at air-liquid interface (ALI) (n = 6 per exposure condition). Corresponding sham exposed samples served as a control. The bro-ALI model was developed using primary bronchial epithelial cells and the alv-ALI model using representative type II pneumocytes (NCI-H441).\r\n\r\nExposure to S1 protein induced the surface expression of ACE2, toll like receptor (TLR) 2, and TLR4 in both bro-ALI and alv-ALI models. Transcript expression analysis identified 117 (bro-ALI) and 97 (alv-ALI) differentially regulated genes (p \u2264 0.01). Pathway analysis revealed enrichment of canonical pathways such as interferon (IFN) signaling, influenza, coronavirus, and anti-viral response in the bro-ALI. Secreted levels of interleukin (IL) 4 and IL12 were significantly (p < 0.05) increased, whereas IL6 decreased in the bro-ALI. In the case of alv-ALI, enriched terms involving p53, APRIL (a proliferation-inducing ligand) tight junction, integrin kinase, and IL1 signaling were identified. These terms are associated with lung fibrosis. Further, significantly (p < 0.05) increased levels of secreted pro-inflammatory cytokines IFN\u03b3, IL1\ua7b5, IL2, IL4, IL6, IL8, IL10, IL13, and tumor necrosis factor alpha were detected in alv-ALI, whereas IL12 was decreased. Altered levels of these cytokines are also associated with lung fibrotic response.\r\n\r\nIn conclusion, we observed a typical anti-viral response in the bronchial model and a pro-fibrotic response in the alveolar model. The bro-ALI and alv-ALI models may serve as an easy and robust platform for assessing the pathogenicity of SARS-CoV-2 variants of concern at different lung regions.", "doi": "10.3390/v13122537", "pmid": "34960806", "labels": {"Category: Biochemistry": null, "Category: Vaccines": null, "Type: Journal article": null, "Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "v13122537"}, {"db": "pmc", "key": "PMC8708014"}, {"db": "URL", "key": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE185657", "description": "Gene Expression Omnibus database at NCBI (GSE185657)."}, {"db": "URL", "key": "https://www.mdpi.com/article/10.3390/v13122537/s1,", "description": "Supplementary material"}], "notes": [], "created": "2022-01-04T15:11:12.348Z", "modified": "2022-01-04T15:17:02.253Z"}, {"entity": "publication", "iuid": "7a685b9a808d41ba8d4943943ba9679f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a685b9a808d41ba8d4943943ba9679f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a685b9a808d41ba8d4943943ba9679f"}}, "title": "COVID-19 and Hygiene Hypothesis: increment of the Inflammatory Bowel Diseases in next generation?", "authors": [{"family": "Shahrbaf", "given": "Mohammad Amin", "initials": "MA"}, {"family": "Hassan", "given": "Moustapha", "initials": "M"}, {"family": "Vosough", "given": "Massoud", "initials": "M"}], "type": "editorial", "published": "2021-12-17", "journal": {"title": "Expert Rev Gastroenterol Hepatol", "issn": "1747-4132", "issn-l": null}, "abstract": null, "doi": "10.1080/17474124.2022.2020647", "pmid": "34919489", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-12-18T17:41:19.125Z", "modified": "2021-12-18T17:41:19.137Z"}, {"entity": "publication", "iuid": "dbfbeda66edb44c19af79e0644236fff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dbfbeda66edb44c19af79e0644236fff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dbfbeda66edb44c19af79e0644236fff"}}, "title": "Age-Stratified Risk of Cerebral Venous Sinus Thrombosis After SARS-CoV-2 Vaccination.", "authors": [{"family": "Krzywicka", "given": "Katarzyna", "initials": "K", "orcid": "0000-0002-9478-0401", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fca2d6da76f7470d8b22079b153956d4.json"}}, {"family": "van de Munckhof", "given": "Anita", "initials": "A"}, {"family": "S\u00e1nchez van Kammen", "given": "Mayte", "initials": "M", "orcid": "0000-0001-5614-9689", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae4f548088eb4c099837e35267755c0b.json"}}, {"family": "Heldner", "given": "Mirjam R", "initials": "MR", "orcid": "0000-0002-3594-2159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8280f8c6ea3a486abae8acc6aa491985.json"}}, {"family": "Jood", "given": "Katarina", "initials": "K"}, {"family": "Lindgren", "given": "Erik", "initials": "E", "orcid": "0000-0002-7628-5044", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e973b3c74ff4e5cba42da605a13bc61.json"}}, {"family": "Tatlisumak", "given": "Turgut", "initials": "T"}, {"family": "Putaala", "given": "Jukka", "initials": "J", "orcid": "0000-0002-6630-6104", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1930f3c097044b3a00d888744dab332.json"}}, {"family": "Kremer Hovinga", "given": "Johanna A", "initials": "JA", "orcid": "0000-0002-1300-7135", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f84022d8c60647929b2d7c45fa2e3849.json"}}, {"family": "Middeldorp", "given": "Saskia", "initials": "S"}, {"family": "Levi", "given": "Marcel M", "initials": "MM"}, {"family": "Cordonnier", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-5697-6892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba080d69348640eb90fba290f58fee11.json"}}, {"family": "Arnold", "given": "Marcel", "initials": "M"}, {"family": "Zwinderman", "given": "Aeilko H", "initials": "AH"}, {"family": "Ferro", "given": "Jos\u00e9 M", "initials": "JM"}, {"family": "Coutinho", "given": "Jonathan M", "initials": "JM", "orcid": "0000-0002-8284-982X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98cadafdcc044688bab25a3d7f9562b9.json"}}, {"family": "Aguiar de Sousa", "given": "Diana", "initials": "D"}], "type": "journal article", "published": "2021-12-17", "journal": {"title": "Neurology", "issn": "1526-632X", "issn-l": "0028-3878"}, "abstract": "Cerebral Venous Sinus Thrombosis (CVST) as a part of the thrombosis and thrombocytopenia syndrome is a rare adverse drug reaction of SARS-CoV-2 vaccination. Estimated background rate of CVST with thrombocytopenia is 0.1 per million per month. We assessed the age-stratified risk of CVST with and without thrombocytopenia after SARS-CoV-2 vaccination.\n\nWe estimated the absolute risk of CVST with and without thrombocytopenia within 28 days of first dose of four SARS-CoV-2 vaccinations, using data from the European Medicines Agency's EudraVigilance database (until 13 June 2021). As a denominator, we used data on vaccine delivery from 31 European countries. For 22.8 million adults from 25 countries, we estimated the absolute risk of CVST after the first dose of ChAdOx1 nCov-19 per age category.\n\nThe absolute risk of CVST within 28 days of first dose vaccination was 7.5 (95%CI 6.9-8.3), 0.7 (95%CI 0.2-2.4), 0.6 (95%CI 0.5-0.7) and 0.6 (95%CI 0.3-1.1) per million of first doses of ChAdOx1 nCov-19, Ad26.COV2.S, BNT162b2 and mRNA-1273, respectively. The absolute risk of CVST with thrombocytopenia within 28 days of first dose vaccination was 4.4 (95%CI 3.9-4.9), 0.7 (95%CI 0.2-2.4), 0.0 (95%CI 0.0-0.1) and 0.0 (95%CI 0.0-0.2) per million of first doses of ChAdOx1 nCov-19, Ad26.COV2.S, BNT162b2 and mRNA-1273, respectively. In recipients of ChAdOx1 nCov-19, the absolute risk of CVST, both with and without thrombocytopenia, was the highest in the 18-24 years age group (7.3 per million, 95%CI 2.8-18.8 and 3.7 per million, 95%CI 1.0-13.3, respectively). The risk of CVST with thrombocytopenia in ChAdOx1 nCov-19 recipients was the lowest in the age group\u226570 years (0.2, 95%CI 0.0-1.3). Age <60 compared to \u226560 was a predictor for CVST with thrombocytopenia (incidence rate ratio 5.79; 95%CI 2.98-11.24, p<0.001).\n\nThe risk of CVST with thrombocytopenia within 28 days of first dose vaccination with ChAdOx1 nCov-19 was higher in younger age groups. The risk of CVST with thrombocytopenia was slightly increased in patients receiving Ad26.COV2.S, compared with the estimated background risk. The risk of CVST with thrombocytopenia was not increased in recipients of SARS-CoV-2 mRNA vaccines.", "doi": "10.1212/WNL.0000000000013148", "pmid": "34921101", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "WNL.0000000000013148"}], "notes": [], "created": "2021-12-20T08:34:08.337Z", "modified": "2021-12-20T08:34:28.616Z"}, {"entity": "publication", "iuid": "a8981553df5d4274aaf529cd2b45a7f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8981553df5d4274aaf529cd2b45a7f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8981553df5d4274aaf529cd2b45a7f4"}}, "title": "", "authors": [{"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Fortea", "given": "Lydia", "initials": "L"}, {"family": "Pomarol-Clotet", "given": "Edith", "initials": "E"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Fullana", "given": "Miquel \u00c0ngel", "initials": "M\u00c0"}, {"family": "Solanes", "given": "Aleix", "initials": "A"}], "type": "case reports", "published": "2021-12-17", "journal": {"title": "Rev Psiquiatr Salud Ment", "issn": "1989-4600", "issn-l": null}, "abstract": null, "doi": "10.1016/j.rpsm.2021.12.004", "pmid": "34934465", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1888-9891(21)00134-8"}, {"db": "pmc", "key": "PMC8679503"}], "notes": [], "created": "2022-01-03T15:32:31.237Z", "modified": "2022-01-03T15:32:31.274Z"}, {"entity": "publication", "iuid": "05e8d837a24143c3978edafe2c1bf029", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/05e8d837a24143c3978edafe2c1bf029.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/05e8d837a24143c3978edafe2c1bf029"}}, "title": "Privacy Personas for IoT-Based Health Research: A Privacy Calculus Approach.", "authors": [{"family": "Maus", "given": "Benjamin", "initials": "B"}, {"family": "Olsson", "given": "Carl Magnus", "initials": "CM"}, {"family": "Salvi", "given": "Dario", "initials": "D"}], "type": "journal article", "published": "2021-12-16", "journal": {"title": "Front Digit Health", "issn": "2673-253X", "volume": "3", "pages": "675754", "issn-l": null}, "abstract": "The reliance on data donation from citizens as a driver for research, known as citizen science, has accelerated during the Sars-Cov-2 pandemic. An important enabler of this is Internet of Things (IoT) devices, such as mobile phones and wearable devices, that allow continuous data collection and convenient sharing. However, potentially sensitive health data raises privacy and security concerns for citizens, which research institutions and industries must consider. In e-commerce or social network studies of citizen science, a privacy calculus related to user perceptions is commonly developed, capturing the information disclosure intent of the participants. In this study, we develop a privacy calculus model adapted for IoT-based health research using citizen science for user engagement and data collection. Based on an online survey with 85 participants, we make use of the privacy calculus to analyse the respondents' perceptions. The emerging privacy personas are clustered and compared with previous research, resulting in three distinct personas which can be used by designers and technologists who are responsible for developing suitable forms of data collection. These are the 1) Citizen Science Optimist, the 2) Selective Data Donor, and the 3) Health Data Controller. Together with our privacy calculus for citizen science based digital health research, the three privacy personas are the main contributions of this study.", "doi": "10.3389/fdgth.2021.675754", "pmid": "34977856", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8716597"}], "notes": [], "created": "2022-01-04T14:43:51.211Z", "modified": "2022-01-04T14:43:51.251Z"}, {"entity": "publication", "iuid": "e070d5249b4e439f89b74961ed0f16fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e070d5249b4e439f89b74961ed0f16fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e070d5249b4e439f89b74961ed0f16fa"}}, "title": "Mechanistic Studies of an Automated Lipid Nanoparticle Reveal Critical Pharmaceutical Properties Associated with Enhanced mRNA Functional Delivery In Vitro and In Vivo.", "authors": [{"family": "Cui", "given": "Lili", "initials": "L", "orcid": "0000-0002-0668-2837", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a298a8143c1042e3a9bf00b0bc6dadd8.json"}}, {"family": "Hunter", "given": "Morag R", "initials": "MR"}, {"family": "Sonzini", "given": "Silvia", "initials": "S"}, {"family": "Pereira", "given": "Sara", "initials": "S"}, {"family": "Romanelli", "given": "Steven M", "initials": "SM"}, {"family": "Liu", "given": "Kai", "initials": "K"}, {"family": "Li", "given": "Weimin", "initials": "W"}, {"family": "Liang", "given": "Lihuan", "initials": "L"}, {"family": "Yang", "given": "Bin", "initials": "B"}, {"family": "Mahmoudi", "given": "Najet", "initials": "N"}, {"family": "Desai", "given": "Arpan S", "initials": "AS"}], "type": "journal article", "published": "2021-12-16", "journal": {"title": "Small", "issn": "1613-6829", "pages": "e2105832", "issn-l": null}, "abstract": "Recently, lipid nanoparticles (LNPs) have attracted attention due to their emergent use for COVID-19 mRNA vaccines. The success of LNPs can be attributed to ionizable lipids, which enable functional intracellular delivery. Previously, the authors established an automated high-throughput platform to screen ionizable lipids and identified that the LNPs generated using this automated technique show comparable or increased mRNA functional delivery in vitro as compared to LNPs prepared using traditional microfluidics techniques. In this study, the authors choose one benchmark lipid, DLin-MC3-DMA (MC3), and investigate whether the automated formulation technique can enhance mRNA functional delivery in vivo. Interestingly, a 4.5-fold improvement in mRNA functional delivery in vivo by automated LNPs as compared to LNPs formulated by conventional microfluidics techniques, is observed. Mechanistic studies reveal that particles with large size accommodate more mRNA per LNP, possess more hydrophobic surface, are more hemolytic, bind a larger protein corona, and tend to accumulate more in macropinocytosomes, which may quantitatively benefit mRNA cytosolic delivery. These data suggest that mRNA loading per particle is a critical factor that accounts for the enhanced mRNA functional delivery of automated LNPs. These mechanistic findings provide valuable insight underlying the enhanced mRNA functional delivery to accelerate future mRNA LNP product development.", "doi": "10.1002/smll.202105832", "pmid": "34914866", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:35:48.170Z", "modified": "2022-01-04T15:36:24.454Z"}, {"entity": "publication", "iuid": "54d97da6ea8f443aa5ddb6a2e05821cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54d97da6ea8f443aa5ddb6a2e05821cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54d97da6ea8f443aa5ddb6a2e05821cc"}}, "title": "An Integrated Deep Learning and Belief Rule Base Intelligent System to Predict Survival of COVID-19 Patient under Uncertainty.", "authors": [{"family": "Ahmed", "given": "Tawsin Uddin", "initials": "TU"}, {"family": "Jamil", "given": "Mohammad Newaj", "initials": "MN"}, {"family": "Hossain", "given": "Mohammad Shahadat", "initials": "MS"}, {"family": "Islam", "given": "Raihan Ul", "initials": "RU", "orcid": "0000-0002-3090-7645", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/597e3542e3fb49d881e100f33115eaf3.json"}}, {"family": "Andersson", "given": "Karl", "initials": "K"}], "type": "journal article", "published": "2021-12-16", "journal": {"title": "Cognit Comput", "issn": "1866-9956", "pages": "1-17", "issn-l": null}, "abstract": "The novel Coronavirus-induced disease COVID-19 is the biggest threat to human health at the present time, and due to the transmission ability of this virus via its conveyor, it is spreading rapidly in almost every corner of the globe. The unification of medical and IT experts is required to bring this outbreak under control. In this research, an integration of both data and knowledge-driven approaches in a single framework is proposed to assess the survival probability of a COVID-19 patient. Several neural networks pre-trained models: Xception, InceptionResNetV2, and VGG Net, are trained on X-ray images of COVID-19 patients to distinguish between critical and non-critical patients. This prediction result, along with eight other significant risk factors associated with COVID-19 patients, is analyzed with a knowledge-driven belief rule-based expert system which forms a probability of survival for that particular patient. The reliability of the proposed integrated system has been tested by using real patient data and compared with expert opinion, where the performance of the system is found promising.", "doi": "10.1007/s12559-021-09978-8", "pmid": "34931129", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "9978"}, {"db": "pmc", "key": "PMC8674031"}], "notes": [], "created": "2022-01-03T15:30:04.377Z", "modified": "2022-01-03T15:30:20.090Z"}, {"entity": "publication", "iuid": "09bb87f27350469aae706ca7d2cc2b45", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/09bb87f27350469aae706ca7d2cc2b45.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/09bb87f27350469aae706ca7d2cc2b45"}}, "title": "[Insights from creating a covid-19 biobank in Sweden].", "authors": [{"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Cornillet", "given": "Martin", "initials": "M"}, {"family": "Rooijackers", "given": "Olav", "initials": "O"}, {"family": "I Eriksson", "given": "Lars", "initials": "L"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas", "initials": "N"}], "type": "journal article", "published": "2021-12-15", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "volume": "118", "issn-l": "0023-7205"}, "abstract": "Biobanks function as important repositories for biological samples collected in health care. As such, they play an important role in enabling important medical research over time. In response to the covid-19 outbreak in Stockholm, Sweden, a group of specialists in intensive care, infectious diseases, and clinical microbiology, as well as scientists with experience in immunology and viral diseases, rapidly gathered. The group discussed how to cope with the prevailing situation, both from a clinical and a research-oriented perspective. Among strategies decided was an attempt to rapidly organize a biological sample collection organized in a biobank for immediate but also long-term research purposes. Given the pandemic conditions with a new virus, the biobank project and associated immediate immunological research tasks turned out to be challenging. In the following months, many lessons were learned from the systematic collection of clinical samples and associated immunological research. Many insights were gained of value for future pandemic preparedness.", "doi": null, "pmid": "34910294", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "21163"}], "notes": [], "created": "2021-12-18T17:49:56.486Z", "modified": "2023-01-13T13:31:26.174Z"}, {"entity": "publication", "iuid": "2a414026535b44c6829650be10fddf84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2a414026535b44c6829650be10fddf84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2a414026535b44c6829650be10fddf84"}}, "title": "Promoting a Syndemic Approach for Cardiometabolic Disease Management During COVID-19: The CAPISCO International Expert Panel.", "authors": [{"family": "Al Mahmeed", "given": "Wael", "initials": "W"}, {"family": "Al-Rasadi", "given": "Khalid", "initials": "K"}, {"family": "Banerjee", "given": "Yajnavalka", "initials": "Y"}, {"family": "Ceriello", "given": "Antonio", "initials": "A"}, {"family": "Cosentino", "given": "Francesco", "initials": "F"}, {"family": "Galia", "given": "Massimo", "initials": "M"}, {"family": "Goh", "given": "Su-Yen", "initials": "SY"}, {"family": "Kempler", "given": "Peter", "initials": "P"}, {"family": "Lessan", "given": "Nader", "initials": "N"}, {"family": "Papanas", "given": "Nikolaos", "initials": "N"}, {"family": "Rizvi", "given": "Ali A", "initials": "AA"}, {"family": "Santos", "given": "Raul D", "initials": "RD"}, {"family": "Stoian", "given": "Anca P", "initials": "AP"}, {"family": "Toth", "given": "Peter P", "initials": "PP"}, {"family": "Rizzo", "given": "Manfredi", "initials": "M"}, {"family": "CArdiometabolic Panel of International experts on Syndemic COvid-19 (CAPISCO)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-15", "journal": {"title": "Front Cardiovasc Med", "issn": "2297-055X", "volume": "8", "pages": "787761", "issn-l": null}, "abstract": "Efforts in the fight against COVID-19 are achieving success in many parts of the world, although progress remains slow in other regions. We believe that a syndemic approach needs to be adopted to address this pandemic given the strong apparent interplay between COVID-19, its related complications, and the socio-structural environment. We have assembled an international, multidisciplinary group of researchers and clinical practitioners to promote a novel syndemic approach to COVID-19: the CArdiometabolic Panel of International experts on Syndemic COvid-19 (CAPISCO). This geographically diverse group aims to facilitate collaborative-networking and scientific exchanges between researchers and clinicians facing a multitude of challenges on different continents during the pandemic. In the present article we present our \"manifesto\", with the intent to provide evidence-based guidance to the global medical and scientific community for better management of patients both during and after the current pandemic.", "doi": "10.3389/fcvm.2021.787761", "pmid": "34977193", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8715947"}], "notes": [], "created": "2022-01-04T14:44:36.587Z", "modified": "2022-01-04T14:44:36.601Z"}, {"entity": "publication", "iuid": "bfe0bc74fda7427ea3ac315a88fe927d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bfe0bc74fda7427ea3ac315a88fe927d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bfe0bc74fda7427ea3ac315a88fe927d"}}, "title": "Experiences of Online COVID-19 Information Acquisition among Persons with Type 2 Diabetes and Varying eHealth Literacy.", "authors": [{"family": "Sj\u00f6str\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Hajdarevic", "given": "Senada", "initials": "S", "orcid": "0000-0003-0661-8269", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9575f7283b80416997f0b3ef20e487b2.json"}}, {"family": "H\u00f6rnsten", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "\u00d6berg", "given": "Ulrika", "initials": "U", "orcid": "0000-0002-2803-8006", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49f675b644a844159d0154b032fec924.json"}}, {"family": "Isaksson", "given": "Ulf", "initials": "U", "orcid": "0000-0001-5191-4599", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac5e6ad1dacd498980527d25095c895f.json"}}], "type": "journal article", "published": "2021-12-15", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "24", "issn-l": null}, "abstract": "During the COVID-19 pandemic, the Internet has been a major source of information for people to keep updated with news and guidelines. However, concerns have been raised about the 'infodemic', which includes the overabundance of online information and the spread of misleading information. Adequate eHealth literacy skills among world citizens have therefore been emphasized as vital during the pandemic. Persons with type 2 diabetes have been at increased risk of severe outcomes of COVID-19 disease. This study aimed to explore online COVID-19 information acquisition experiences among persons with type 2 diabetes and varying eHealth literacy. Fifty-eight participants filled out the eHealth Literacy Scale (eHEALS), along with a qualitative questionnaire with free-text questions. Additionally, 10 participants were interviewed. Thematic analysis was applied to identify patterns in participants' experiences. Two domains were identified: perceived challenges with online information about COVID-19, and coping strategies to manage challenges. The perceived challenges were: being exposed to information overload, dealing with conflicting information, and being strongly emotionally affected. The related coping strategies were: protecting oneself, trusting authorities, taking command, and using common sense. These strategies often involved triangulation of the information obtained, including participants consulting their common sense, various sources, or family and friends. This paper highlights the crucial role of authorities in delivering online information, that according to health literacy principles, is easy to access, understand, and use. Furthermore, our results reinforce the importance of diabetes nurses, as well as healthcare professionals in general, in encouraging patients to share their Internet findings, promote information from reliable sources, and deliver tailored information that suits individual needs. Because our results underline the importance of social support in eHealth literacy and the assessment of online health information, the inclusion of family and friends needs to be increasingly considered in diabetes care. Due to the small homogenous sample, the results of this study cannot be generalized. However, the reader can assess the transferability to other situations and settings based on our contextual descriptions.", "doi": "10.3390/ijerph182413240", "pmid": "34948852", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182413240"}, {"db": "pmc", "key": "PMC8701656"}], "notes": [], "created": "2022-01-04T15:29:32.581Z", "modified": "2022-01-04T15:29:32.750Z"}, {"entity": "publication", "iuid": "ba0357094cd74fde9ff8bf38087793f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ba0357094cd74fde9ff8bf38087793f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ba0357094cd74fde9ff8bf38087793f7"}}, "title": "Dapagliflozin in patients with COVID-19: mind the kidneys - Authors' reply.", "authors": [{"family": "Kosiborod", "given": "Mikhail N", "initials": "MN"}, {"family": "Esterline", "given": "Russell", "initials": "R"}, {"family": "Oscarsson", "given": "Jan", "initials": "J"}, {"family": "Gasparyan", "given": "Samvel B", "initials": "SB"}, {"family": "Furtado", "given": "Remo H M", "initials": "RHM"}, {"family": "Verma", "given": "Subodh", "initials": "S"}, {"family": "Berwanger", "given": "Otavio", "initials": "O"}], "type": "letter", "published": "2021-12-15", "journal": {"title": "Lancet Diabetes Endocrinol", "issn": "2213-8595", "issn-l": null}, "abstract": null, "doi": "10.1016/S2213-8587(21)00326-0", "pmid": "34921753", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-8587(21)00326-0"}], "notes": [], "created": "2021-12-20T08:33:08.636Z", "modified": "2021-12-20T08:33:08.651Z"}, {"entity": "publication", "iuid": "c58762d3b71e4eaba096566c42f6a804", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c58762d3b71e4eaba096566c42f6a804.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c58762d3b71e4eaba096566c42f6a804"}}, "title": "Acute COVID-19 severity and 16-month mental morbidity trajectories in patient populations of six nations", "authors": [{"family": "Magn\u00fasd\u00f3ttir", "given": "Ingibj\u00f6rg", "initials": "I", "orcid": "0000-0002-1983-6049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/774d5ab207a74688accb27001d15e4aa.json"}}, {"family": "Lovik", "given": "Anik\u00f3", "initials": "A"}, {"family": "Unnarsd\u00f3ttir", "given": "Anna B\u00e1ra", "initials": "AB", "orcid": "0000-0002-6421-445X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2da21ebd675c4e329c47bf64bbc1578a.json"}}, {"family": "McCartney", "given": "Daniel", "initials": "D"}, {"family": "Ask", "given": "Helga", "initials": "H"}, {"family": "K\u00f5iv", "given": "Kadri", "initials": "K"}, {"family": "Nordahl Christoffersen", "given": "Lea Arregui", "initials": "LA"}, {"family": "Johnson", "given": "Sverre Urnes", "initials": "SU"}, {"family": "McIntosh", "given": "Andrew", "initials": "A", "orcid": "0000-0002-0198-4588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc50c9e995964aa5be11a155b7f95c64.json"}}, {"family": "K\u00e4hler", "given": "Anna K", "initials": "AK"}, {"family": "Campbell", "given": "Archie", "initials": "A"}, {"family": "Hauksd\u00f3ttir", "given": "Arna", "initials": "A"}, {"family": "Fawns-Ritchie", "given": "Chloe", "initials": "C"}, {"family": "Erikstrup", "given": "Christian", "initials": "C", "orcid": "0000-0001-6551-6647", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f01382b51d3e46d8b8c9d74dbed3ce81.json"}}, {"family": "Helenius", "given": "Dorte", "initials": "D"}, {"family": "Altschul", "given": "Drew", "initials": "D"}, {"family": "Thordardottir", "given": "Edda Bjork", "initials": "EB"}, {"family": "Ey\u00fe\u00f3rsson", "given": "El\u00edas", "initials": "E"}, {"family": "Frans", "given": "Emma M", "initials": "EM"}, {"family": "T\u00f3masson", "given": "Gunnar", "initials": "G"}, {"family": "J\u00f3nsd\u00f3ttir", "given": "Harpa Lind", "initials": "HL"}, {"family": "R\u00fanarsd\u00f3ttir", "given": "Harpa", "initials": "H"}, {"family": "Hjalgrim", "given": "Henrik", "initials": "H"}, {"family": "Har\u00f0ard\u00f3ttir", "given": "Hr\u00f6nn", "initials": "H"}, {"family": "Gonz\u00e1lez-Hij\u00f3n", "given": "Juan", "initials": "J"}, {"family": "Banasik", "given": "Karina", "initials": "K"}, {"family": "Dinh", "given": "Khoa Manh", "initials": "KM"}, {"family": "Lu", "given": "Li", "initials": "L"}, {"family": "Milani", "given": "Lili", "initials": "L"}, {"family": "Trogstad", "given": "Lill", "initials": "L"}, {"family": "Didriksen", "given": "Maria", "initials": "M"}, {"family": "Ebrahimi", "given": "Omid V", "initials": "OV"}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF"}, {"family": "Magnus", "given": "Per Minor", "initials": "PM"}, {"family": "Shen", "given": "Qing", "initials": "Q"}, {"family": "Nesv\u00e5g", "given": "Ragnar", "initials": "R"}, {"family": "M\u00e4gi", "given": "Reedik", "initials": "R"}, {"family": "P\u00e1lsson", "given": "Run\u00f3lfur", "initials": "R", "orcid": "0000-0001-6763-1702", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df1c1ec369a54d3ba12048edb675ab6a.json"}}, {"family": "Ostrowski", "given": "Sisse Rye", "initials": "SR"}, {"family": "Werge", "given": "Thomas", "initials": "T"}, {"family": "Hoffart", "given": "Asle", "initials": "A"}, {"family": "Porteous", "given": "David J", "initials": "DJ"}, {"family": "Fang", "given": "Fang", "initials": "F", "orcid": "0000-0002-3310-6456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b0852465cd14239a25329b976172792.json"}}, {"family": "Jakobsd\u00f3ttir", "given": "J\u00f3hanna", "initials": "J"}, {"family": "Lehto", "given": "Kelli", "initials": "K"}, {"family": "Andreassen", "given": "Ole A", "initials": "OA", "orcid": "0000-0002-4461-3568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f105232b5e5a443abbc17ac88f9b4ad6.json"}}, {"family": "Pedersen", "given": "Ole B V", "initials": "OBV"}, {"family": "Aspelund", "given": "Thor", "initials": "T", "orcid": "0000-0002-7998-5433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f3b5030190743e4b0ec0be05afb8fa8.json"}}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur Anna", "initials": "UA", "orcid": "0000-0001-5382-946X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87d1dbec7c6f4942b1db2b999eeb9ece.json"}}], "type": "posted-content", "published": "2021-12-15", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.12.13.21267368", "pmid": null, "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2023-02-13T18:39:49.120Z", "modified": "2023-02-13T18:39:49.262Z"}, {"entity": "publication", "iuid": "603e4932d45040fe8bf99638dd6c7b31", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/603e4932d45040fe8bf99638dd6c7b31.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/603e4932d45040fe8bf99638dd6c7b31"}}, "title": "The impact of the COVID-19 school closure on adolescents\u2019 use of mental healthcare services in Sweden", "authors": [{"family": "Svaleryd", "given": "Helena", "initials": "H", "orcid": "0000-0003-3072-5224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79dfce3f625e418490cac3f369f3e9e8.json"}}, {"family": "Bj\u00f6rkegren", "given": "Evelina", "initials": "E"}, {"family": "Vlachos", "given": "Jonas", "initials": "J", "orcid": "0000-0002-7717-9155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b8b751862ab4c34b580e5ace974b36c.json"}}], "type": "posted-content", "published": "2021-12-14", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.12.12.21267684", "pmid": null, "labels": {"Category: Other": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:45:44.699Z", "modified": "2022-11-22T05:43:32.647Z"}, {"entity": "publication", "iuid": "b027237f614b41f59ccd65d0b432edea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b027237f614b41f59ccd65d0b432edea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b027237f614b41f59ccd65d0b432edea"}}, "title": "Harnessing Twitter data to survey public attention and attitudes towards COVID-19 vaccines in the UK.", "authors": [{"family": "Fazel", "given": "Seena", "initials": "S"}, {"family": "Zhang", "given": "Le", "initials": "L"}, {"family": "Javid", "given": "Babak", "initials": "B"}, {"family": "Brikell", "given": "Isabell", "initials": "I"}, {"family": "Chang", "given": "Zheng", "initials": "Z"}], "type": "journal article", "published": "2021-12-14", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "23402", "issn-l": "2045-2322"}, "abstract": "Attitudes to COVID-19 vaccination vary considerably within and between countries. Although the contribution of socio-demographic factors to these attitudes has been studied, the role of social media and how it interacts with news about vaccine development and efficacy is uncertain. We examined around 2 million tweets from 522,893 persons in the UK from November 2020 to January 2021 to evaluate links between Twitter content about vaccines and major scientific news announcements about vaccines. The proportion of tweets with negative vaccine content varied, with reductions of 20-24% on the same day as major news announcement. However, the proportion of negative tweets reverted back to an average of around 40% within a few days. Engagement rates were higher for negative tweets. Public health messaging could consider the dynamics of Twitter-related traffic and the potential contribution of more targeted social media campaigns to address vaccine hesitancy.", "doi": "10.1038/s41598-021-02710-4", "pmid": "34907201", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-02710-4"}], "notes": [], "created": "2021-12-18T17:53:48.734Z", "modified": "2021-12-18T17:53:48.747Z"}, {"entity": "publication", "iuid": "0e9ffe8c65604633a45f7f253a9ee75f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e9ffe8c65604633a45f7f253a9ee75f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e9ffe8c65604633a45f7f253a9ee75f"}}, "title": "Estimating the SARS-CoV-2 infected population fraction and the infection-to-fatality ratio: a data-driven case study based on Swedish time series data.", "authors": [{"family": "Wacker", "given": "Andreas", "initials": "A"}, {"family": "J\u00f6ud", "given": "Anna", "initials": "A", "orcid": "0000-0001-7192-4911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e038a5ce2f5a47bd89e7c221651a3d24.json"}}, {"family": "Bernhardsson", "given": "Bo", "initials": "B"}, {"family": "Gerlee", "given": "Philip", "initials": "P", "orcid": "0000-0001-8503-0177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ba426c1ab741e781d2b9cd09a0b830.json"}}, {"family": "Gustafsson", "given": "Fredrik", "initials": "F"}, {"family": "Soltesz", "given": "Kristian", "initials": "K"}], "type": "journal article", "published": "2021-12-14", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "23963", "issn-l": "2045-2322"}, "abstract": "We demonstrate that finite impulse response (FIR) models can be applied to analyze the time evolution of an epidemic with its impact on deaths and healthcare strain. Using time series data for COVID-19-related cases, ICU admissions and deaths from Sweden, the FIR model gives a consistent epidemiological trajectory for a simple delta filter function. This results in a consistent scaling between the time series if appropriate time delays are applied and allows the reconstruction of cases for times before July 2020, when RT-PCR testing was not widely available. Combined with randomized RT-PCR study results, we utilize this approach to estimate the total number of infections in Sweden, and the corresponding infection-to-fatality ratio (IFR), infection-to-case ratio (ICR), and infection-to-ICU admission ratio (IIAR). Our values for IFR, ICR and IIAR are essentially constant over large parts of 2020 in contrast with claims of healthcare adaptation or mutated virus variants importantly affecting these ratios. We observe a diminished IFR in late summer 2020 as well as a strong decline during 2021, following the launch of a nation-wide vaccination program. The total number of infections during 2020 is estimated to 1.3 million, indicating that Sweden was far from herd immunity.", "doi": "10.1038/s41598-021-03269-w", "pmid": "34907208", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8671402"}, {"db": "pii", "key": "10.1038/s41598-021-03269-w"}], "notes": [], "created": "2021-12-18T17:52:24.620Z", "modified": "2023-06-19T15:31:02.834Z"}, {"entity": "publication", "iuid": "fcca4b56268f4b11ba3093964206d768", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fcca4b56268f4b11ba3093964206d768.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fcca4b56268f4b11ba3093964206d768"}}, "title": "ECG pathology and its association with death in critically ill COVID-19 patients, a cohort study.", "authors": [{"family": "Ros\u00e9n", "given": "Jacob", "initials": "J", "orcid": "0000-0001-9518-5834", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ce3d5b2cb914d72bbd476b7e1127c8d.json"}}, {"family": "Noreland", "given": "Maria", "initials": "M"}, {"family": "Stattin", "given": "Karl", "initials": "K"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Malinovschi", "given": "Andrei", "initials": "A"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Uppsala Intensive Care COVID-19 Research Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-14", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "12", "pages": "e0261315"}, "abstract": "We investigated the prevalence of ECG abnormalities and their association with mortality, organ dysfunction and cardiac biomarkers in a cohort of COVID-19 patients admitted to the intensive care unit (ICU).\r\n\r\nThis cohort study included patients with COVID-19 admitted to the ICU of a tertiary hospital in Sweden. ECG, clinical data and laboratory findings during ICU stay were extracted from medical records and ECGs obtained near ICU admission were reviewed by two independent physicians.\r\n\r\nEighty patients had an acceptable ECG near ICU-admission. In the entire cohort 30-day mortality was 28%. Compared to patients with normal ECG, among whom 30-day mortality was 16%, patients with ECG fulfilling criteria for prior myocardial infarction had higher mortality, 63%, odds ratio (OR) 9.61 (95% confidence interval (CI) 2.02-55.6) adjusted for Simplified Acute Physiology Score 3 and patients with ST-T abnormalities had 50% mortality and OR 6.05 (95% CI 1.82-21.3) in univariable analysis. Both prior myocardial infarction pattern and ST-T pathology were associated with need for vasoactive treatment and higher peak plasma levels of troponin-I, NT-pro-BNP (N-terminal pro-Brain Natriuretic Peptide), and lactate during ICU stay compared to patients with normal ECG.\r\n\r\nECG with prior myocardial infarction pattern or acute ST-T pathology at ICU admission is associated with death, need for vasoactive treatment and higher levels of biomarkers of cardiac damage and strain in severely ill COVID-19 patients, and should alert clinicians to a poor prognosis.", "doi": "10.1371/journal.pone.0261315", "pmid": "34905575", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Public Health": null, "Funder: VR": null, "Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-28860"}, {"db": "pmc", "key": "PMC8670711"}, {"db": "URL", "key": "https://doi.org/10.1371/journal.pone.0261315.s001", "description": "https://doi.org/10.1371/journal.pone.0261315.s001"}, {"db": "URL", "key": "https://doi.org/10.17044/scilifelab.14229410.v1", "description": "https://doi.org/10.17044/scilifelab.14229410.v1"}], "notes": [], "created": "2021-12-18T17:54:37.568Z", "modified": "2021-12-18T17:57:22.337Z"}, {"entity": "publication", "iuid": "144f781f894f4fa89b8d27a5bb748f5c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/144f781f894f4fa89b8d27a5bb748f5c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/144f781f894f4fa89b8d27a5bb748f5c"}}, "title": "Does Confinement Affect Treatment Dropout Rates in Patients With Gambling Disorder? A Nine-Month Observational Study.", "authors": [{"family": "Baenas", "given": "Isabel", "initials": "I"}, {"family": "Etxandi", "given": "Mikel", "initials": "M"}, {"family": "Codina", "given": "Ester", "initials": "E"}, {"family": "Granero", "given": "Roser", "initials": "R"}, {"family": "Fern\u00e1ndez-Aranda", "given": "Fernando", "initials": "F"}, {"family": "G\u00f3mez-Pe\u00f1a", "given": "M\u00f3nica", "initials": "M"}, {"family": "Moragas", "given": "Laura", "initials": "L"}, {"family": "Rivas", "given": "Sandra", "initials": "S"}, {"family": "Potenza", "given": "Marc N", "initials": "MN"}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "Del Pino-Guti\u00e9rrez", "given": "Amparo", "initials": "A"}, {"family": "Mora-Maltas", "given": "Bernat", "initials": "B"}, {"family": "Valenciano-Mendoza", "given": "Eduardo", "initials": "E"}, {"family": "Mench\u00f3n", "given": "Jos\u00e9 M", "initials": "JM"}, {"family": "Jim\u00e9nez-Murcia", "given": "Susana", "initials": "S"}], "type": "journal article", "published": "2021-12-14", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "761802", "issn-l": "1664-1078"}, "abstract": "Background and Aims: COVID-19 pandemic and confinement have represented a challenge for patients with gambling disorder (GD). Regarding treatment outcome, dropout may have been influenced by these adverse circumstances. The aims of this study were: (a) to analyze treatment dropout rates in patients with GD throughout two periods: during and after the lockdown and (b) to assess clinical features that could represent vulnerability factors for treatment dropout. Methods: The sample consisted of n=86 adults, mostly men (n=79, 91.9%) and with a mean age of 45years old (SD=16.85). Patients were diagnosed with GD according to DSM-5 criteria and were undergoing therapy at a Behavioral Addiction Unit when confinement started. Clinical data were collected through a semi-structured interview and protocolized psychometric assessment. A brief telephone survey related to COVID-19 concerns was also administered at the beginning of the lockdown. Dropout data were evaluated at two moments throughout a nine-month observational period (T1: during the lockdown, and T2: after the lockdown). Results: The risk of dropout during the complete observational period was R=32/86=0.372 (37.2%), the Incidence Density Rate (IDR) ratio T2/T1 being equal to 0.052/0.033=1.60 (p=0.252). Shorter treatment duration (p=0.007), lower anxiety (p=0.025), depressive symptoms (p=0.045) and lower use of adaptive coping strategies (p=0.046) characterized patients who abandoned treatment during the lockdown. Briefer duration of treatment (p=0.001) and higher employment concerns (p=0.044) were highlighted in the individuals who dropped out after the lockdown. Treatment duration was a predictor of dropout in both periods (p=0.005 and p<0.001, respectively). Conclusion: The present results suggest an impact of the COVID-19 pandemic on treatment dropout among patients with GD during and after the lockdown, being treatment duration a predictor of dropout. Assessing vulnerability features in GD may help clinicians identify high-risk individuals and enhance prevention and treatment approaches in future similar situations.", "doi": "10.3389/fpsyg.2021.761802", "pmid": "34970193", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8712884"}], "notes": [], "created": "2022-01-04T14:58:37.916Z", "modified": "2022-01-04T14:58:37.933Z"}, {"entity": "publication", "iuid": "7ac9e51b73514b76bbabcc91dab96516", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7ac9e51b73514b76bbabcc91dab96516.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7ac9e51b73514b76bbabcc91dab96516"}}, "title": "Comprehensive Contact Tracing, Testing and Sequencing Show Limited Transmission of SARS-CoV-2 between Children in Schools in Norway, August 2020 to May 2021.", "authors": [{"family": "Winje", "given": "Brita Askeland", "initials": "BA", "orcid": "0000-0003-2858-7248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff6f41b97fb5447cb80574cb6e671a80.json"}}, {"family": "Ofitserova", "given": "Trine Skogset", "initials": "TS"}, {"family": "Brynildsrud", "given": "Ola Br\u00f8nstad", "initials": "OB"}, {"family": "Greve-Isdahl", "given": "Margrethe", "initials": "M"}, {"family": "Bragstad", "given": "Karoline", "initials": "K"}, {"family": "Rykkvin", "given": "Rikard", "initials": "R"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "Lund", "given": "Hilde Marie", "initials": "HM"}, {"family": "Nyg\u00e5rd", "given": "Karin", "initials": "K"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}, {"family": "Brandal", "given": "Lin Thorstensen", "initials": "LT"}], "type": "journal article", "published": "2021-12-14", "journal": {"title": "Microorganisms", "issn": "2076-2607", "volume": "9", "issue": "12", "issn-l": "2076-2607"}, "abstract": "The role of children in the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in schools has been a topic of controversy. In this study among school contacts of SARS-CoV-2 positive children in 43 contact-investigations, we investigated SARS-CoV-2 transmission in Norway, August 2020-May 2021. All participants were tested twice within seven to ten days, using SARS-CoV-2 PCR on home-sampled saliva. Positive samples were whole genome sequenced. Among the 559 child contacts, eight tested positive (1.4%, 95% CI 0.62-2.80), with no significant difference between primary (1.0%, 95% CI 0.27-2.53) and secondary schools (2.6%, 95% CI 0.70-6.39), p = 0.229, nor by viral strain, non-Alpha (1.4%, 95% CI 0.50-2.94) and Alpha variant (B.1.1.7) (1.7%, 95% CI 0.21-5.99), p = 0.665. One adult contact (1/100) tested positive. In 34 index cases, we detected 13 different SARS-CoV-2 Pango lineage variants, with B.1.1.7 being most frequent. In the eight contact-investigations with SARS-CoV-2 positive contacts, four had the same sequence identity as the index, one had no relation, and three were inconclusive. With mitigation measures in place, the spread of SARS-CoV-2 from children in schools is limited. By excluding contact-investigations with adult cases known at the time of enrolment, our data provide a valid estimate on the role of children in the transmission of SARS-CoV-2 in schools.", "doi": "10.3390/microorganisms9122587", "pmid": "34946187", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "microorganisms9122587"}, {"db": "pmc", "key": "PMC8705768"}], "notes": [], "created": "2022-01-04T15:31:42.547Z", "modified": "2022-01-04T15:31:42.605Z"}, {"entity": "publication", "iuid": "8f1e7fb4b8374e2eb1cda889dcc4a2b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f1e7fb4b8374e2eb1cda889dcc4a2b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f1e7fb4b8374e2eb1cda889dcc4a2b2"}}, "title": "Broad anti-SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1/mRNA-1273 prime-boost vaccination", "authors": [{"family": "Kaku", "given": "Chengzi I", "initials": "CI", "orcid": "0000-0002-9854-8351", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be56dead52324203a9b37fc32f23626f.json"}}, {"family": "Champney", "given": "Elizabeth R", "initials": "ER"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Johnson", "given": "Carl E", "initials": "CE"}, {"family": "Ahlm", "given": "Clas", "initials": "C", "orcid": "0000-0003-2018-8592", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/833d0293b5d74bbabec63e922cd19d54.json"}}, {"family": "Sakharkar", "given": "Mrunal", "initials": "M", "orcid": "0000-0002-2717-5201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2694a69ce874c3f93cf4f9ed8d736dd.json"}}, {"family": "Ackerman", "given": "Margaret E", "initials": "ME", "orcid": "0000-0002-4253-3476", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10fea712c93441dd922bbcb531b46148.json"}}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE", "orcid": "0000-0001-6904-742X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e41c0e1c9c7b499fb3d844d4c572e7bb.json"}}, {"family": "Walker", "given": "Laura M", "initials": "LM", "orcid": "0000-0001-7704-3197", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a40fc6cfefc14436a12cc467c3cacd54.json"}}], "type": "posted-content", "published": "2021-12-14", "journal": {"title": "MedRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.12.13.21267598", "pmid": null, "labels": {"Type: Preprint": null, "Category: Vaccines": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Research Area: Vaccine": null, "Funder: VR": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:46:15.910Z", "modified": "2022-02-14T14:55:09.518Z"}, {"entity": "publication", "iuid": "9633f53476a44e038f64329f6684a8ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9633f53476a44e038f64329f6684a8ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9633f53476a44e038f64329f6684a8ee"}}, "title": "Biomarkers Predict In-Hospital Major Adverse Cardiac Events in COVID-19 Patients: A Multicenter International Study.", "authors": [{"family": "Henein", "given": "Michael Y", "initials": "MY", "orcid": "0000-0002-6089-5614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe79bb10eb4348948599443b7b396faf.json"}}, {"family": "Mandoli", "given": "Giulia Elena", "initials": "GE", "orcid": "0000-0002-3184-3006", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc927b7843b44bdd87232563c7faff19.json"}}, {"family": "Pastore", "given": "Maria Concetta", "initials": "MC", "orcid": "0000-0002-7223-141X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/55e79d1bf0294864ae1cdb57aa4a4844.json"}}, {"family": "Ghionzoli", "given": "Nicol\u00f2", "initials": "N"}, {"family": "Hasson", "given": "Fouhad", "initials": "F"}, {"family": "Nisar", "given": "Muhammad K", "initials": "MK", "orcid": "0000-0002-5132-3972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/57bb7f7ab7c04904a4c0032679c32880.json"}}, {"family": "Islam", "given": "Mohammed", "initials": "M"}, {"family": "Bandera", "given": "Francesco", "initials": "F"}, {"family": "Marrocco-Trischitta", "given": "Massimiliano M", "initials": "MM"}, {"family": "Baroni", "given": "Irene", "initials": "I"}, {"family": "Malagoli", "given": "Alessandro", "initials": "A", "orcid": "0000-0001-9119-4311", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3808163253445a0923454d2df22ad30.json"}}, {"family": "Rossi", "given": "Luca", "initials": "L"}, {"family": "Biagi", "given": "Andrea", "initials": "A"}, {"family": "Citro", "given": "Rodolfo", "initials": "R"}, {"family": "Ciccarelli", "given": "Michele", "initials": "M", "orcid": "0000-0003-2379-1960", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d76634bdc8024f53ba78a6e72ab3d041.json"}}, {"family": "Silverio", "given": "Angelo", "initials": "A", "orcid": "0000-0001-9749-8092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/610b8ded802247ceb13def87bcc5a1d7.json"}}, {"family": "Biagioni", "given": "Giulia", "initials": "G"}, {"family": "Moutiris", "given": "Joseph A", "initials": "JA"}, {"family": "Vancheri", "given": "Federico", "initials": "F", "orcid": "0000-0002-5268-063X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c112118f1d94c1a95466127919064e4.json"}}, {"family": "Mazzola", "given": "Giovanni", "initials": "G"}, {"family": "Geraci", "given": "Giulio", "initials": "G"}, {"family": "Thomas", "given": "Liza", "initials": "L"}, {"family": "Altman", "given": "Mikhail", "initials": "M"}, {"family": "Pernow", "given": "John", "initials": "J"}, {"family": "Ahmed", "given": "Mona", "initials": "M", "orcid": "0000-0002-9579-1380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4164b11cface4f849c5e08bf41c8c5d9.json"}}, {"family": "Santoro", "given": "Ciro", "initials": "C", "orcid": "0000-0002-6329-1680", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2e9af60986147238aff6cd0dd5e9600.json"}}, {"family": "Esposito", "given": "Roberta", "initials": "R"}, {"family": "Casas", "given": "Guillem", "initials": "G", "orcid": "0000-0001-7122-320X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f0ed65a87cc40a28c45996b0510981a.json"}}, {"family": "Fern\u00e1ndez-Galera", "given": "Rub\u00e9n", "initials": "R"}, {"family": "Gonzalez", "given": "Maribel", "initials": "M"}, {"family": "Rodriguez Palomares", "given": "Jose", "initials": "J"}, {"family": "Byty\u00e7i", "given": "Ibadete", "initials": "I", "orcid": "0000-0002-8996-4257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba2f218876104573a8e529b1c2b6f671.json"}}, {"family": "Dini", "given": "Frank Lloyd", "initials": "FL", "orcid": "0000-0003-1458-4820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/548dbd176bf0475b8c70c8942610312b.json"}}, {"family": "Cameli", "given": "Paolo", "initials": "P", "orcid": "0000-0001-8639-2882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30defb513b86480dbeb48f1b75c95327.json"}}, {"family": "Franchi", "given": "Federico", "initials": "F"}, {"family": "Bajraktari", "given": "Gani", "initials": "G", "orcid": "0000-0003-0410-968X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a2b0b473f4e471fb3443c28bf9002b9.json"}}, {"family": "Badano", "given": "Luigi Paolo", "initials": "LP"}, {"family": "Cameli", "given": "Matteo", "initials": "M", "orcid": "0000-0003-3872-8964", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e64899d051a84cd8a0cac5f503e03251.json"}}], "type": "journal article", "published": "2021-12-14", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "10", "issue": "24", "issn-l": "2077-0383"}, "abstract": "The COVID-19 pandemic carries a high burden of morbidity and mortality worldwide. We aimed to identify possible predictors of in-hospital major cardiovascular (CV) events in COVID-19.\n\nWe retrospectively included patients hospitalized for COVID-19 from 10 centers. Clinical, biochemical, electrocardiographic, and imaging data at admission and medications were collected. Primary endpoint was a composite of in-hospital CV death, acute heart failure (AHF), acute myocarditis, arrhythmias, acute coronary syndromes (ACS), cardiocirculatory arrest, and pulmonary embolism (PE).\n\nOf the 748 patients included, 141(19%) reached the set endpoint: 49 (7%) CV death, 15 (2%) acute myocarditis, 32 (4%) sustained-supraventricular or ventricular arrhythmias, 14 (2%) cardiocirculatory arrest, 8 (1%) ACS, 41 (5%) AHF, and 39 (5%) PE. Patients with CV events had higher age, body temperature, creatinine, high-sensitivity troponin, white blood cells, and platelet counts at admission and were more likely to have systemic hypertension, renal failure (creatinine \u2265 1.25 mg/dL), chronic obstructive pulmonary disease, atrial fibrillation, and cardiomyopathy. On univariate and multivariate analysis, troponin and renal failure were associated with the composite endpoint. Kaplan-Meier analysis showed a clear divergence of in-hospital composite event-free survival stratified according to median troponin value and the presence of renal failure (Log rank p < 0.001).\n\nOur findings, derived from a multicenter data collection study, suggest the routine use of biomarkers, such as cardiac troponin and serum creatinine, for in-hospital prediction of CV events in patients with COVID-19.", "doi": "10.3390/jcm10245863", "pmid": "34945166", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "jcm10245863"}, {"db": "pmc", "key": "PMC8703972"}], "notes": [], "created": "2022-01-04T15:32:03.472Z", "modified": "2022-01-04T15:32:03.918Z"}, {"entity": "publication", "iuid": "19cbe373455c4122b9b149c0f0f6afa6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19cbe373455c4122b9b149c0f0f6afa6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19cbe373455c4122b9b149c0f0f6afa6"}}, "title": "Sleep and daytime problems during the COVID-19 pandemic and effects of coronavirus infection, confinement and financial suffering: a multinational survey using a harmonised questionnaire.", "authors": [{"family": "Partinen", "given": "Markku", "initials": "M", "orcid": "0000-0002-8182-9368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7920bcc4716848f7bd1cb89c8bdd0d5a.json"}}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "Espie", "given": "Colin", "initials": "C"}, {"family": "Chung", "given": "Frances", "initials": "F", "orcid": "0000-0001-9576-3606", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed55f48b6d8e400b8fd2c591a738260a.json"}}, {"family": "Penzel", "given": "Thomas", "initials": "T", "orcid": "0000-0002-4304-0112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0dc4e472c71460ab792f74bc8163a9a.json"}}, {"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Bolstad", "given": "Courtney J", "initials": "CJ"}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J"}, {"family": "Chan", "given": "Rachel Ngan Yin", "initials": "RNY"}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L"}, {"family": "Han", "given": "Fang", "initials": "F"}, {"family": "Inoue", "given": "Yuichi", "initials": "Y"}, {"family": "Matsui", "given": "Kentaro", "initials": "K"}, {"family": "Leger", "given": "Damien", "initials": "D"}, {"family": "Cunha", "given": "Ana Suely", "initials": "AS"}, {"family": "Merikanto", "given": "Ilona", "initials": "I"}, {"family": "Mota-Rolim", "given": "Sergio", "initials": "S"}, {"family": "Nadorff", "given": "Michael", "initials": "M"}, {"family": "Plazzi", "given": "Giuseppe", "initials": "G"}, {"family": "Schneider", "given": "Jules", "initials": "J"}, {"family": "Sieminski", "given": "Mariusz", "initials": "M"}, {"family": "Wing", "given": "Yun-Kwok", "initials": "Y"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B", "orcid": "0000-0001-7051-745X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b72d97a35fa4590b5d05f0fd3524f2e.json"}}], "type": "journal article", "published": "2021-12-13", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "12", "pages": "e050672"}, "abstract": "Sleep is important for human health and well-being. No previous study has assessed whether the COVID-19 pandemic impacts sleep and daytime function across the globe.\r\n\r\nThis large-scale international survey used a harmonised questionnaire. Fourteen countries participated during the period of May-August 2020. Sleep and daytime problems (poor sleep quality, sleep onset and maintenance problems, nightmares, hypnotic use, fatigue and excessive sleepiness) occurring 'before' and 'during' the pandemic were investigated. In total, 25 484 people participated and 22 151 (86.9%) responded to the key parameters and were included. Effects of COVID-19, confinement and financial suffering were considered. In the fully adjusted logistic regression models, results (weighted and stratified by country) were adjusted for gender, age, marital status, educational level, ethnicity, presence of sleep problems before COVID-19 and severity of the COVID-19 pandemic in each country at the time of the survey.\r\n\r\nThe responders were mostly women (64%) with a mean age 41.8 (SD 15.9) years (median 39, range 18-95). Altogether, 3.0% reported having had COVID-19; 42.2% reported having been in confinement; and 55.9% had suffered financially. All sleep and daytime problems worsened during the pandemic by about 10% or more. Also, some participants reported improvements in sleep and daytime function. For example, sleep quality worsened in about 20% of subjects and improved in about 5%. COVID-19 was particularly associated with poor sleep quality, early morning awakening and daytime sleepiness. Confinement was associated with poor sleep quality, problems falling asleep and decreased use of hypnotics. Financial suffering was associated with all sleep and daytime problems, including nightmares and fatigue, even in the fully adjusted logistic regression models.\r\n\r\nSleep problems, fatigue and excessive sleepiness increased significantly worldwide during the first phase of the COVID-19 pandemic. Problems were associated with confinement and especially with financial suffering.", "doi": "10.1136/bmjopen-2021-050672", "pmid": "34903540", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-050672"}, {"db": "pmc", "key": "PMC8671846"}], "notes": [], "created": "2021-12-18T17:58:46.977Z", "modified": "2022-11-22T05:44:08.358Z"}, {"entity": "publication", "iuid": "6276d42a70524ee0bbfd239bccd5247a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6276d42a70524ee0bbfd239bccd5247a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6276d42a70524ee0bbfd239bccd5247a"}}, "title": "Pre-pandemic psychological and behavioral predictors of responses to the COVID-19 pandemic in nine countries.", "authors": [{"family": "Lansford", "given": "Jennifer E", "initials": "JE", "orcid": "0000-0003-1956-4917", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/099f957450e743acab538878cc487a27.json"}}, {"family": "Skinner", "given": "Ann T", "initials": "AT"}, {"family": "Godwin", "given": "Jennifer", "initials": "J"}, {"family": "Chang", "given": "Lei", "initials": "L"}, {"family": "Deater-Deckard", "given": "Kirby", "initials": "K"}, {"family": "Di Giunta", "given": "Laura", "initials": "L"}, {"family": "Dodge", "given": "Kenneth A", "initials": "KA"}, {"family": "Gurdal", "given": "Sevtap", "initials": "S"}, {"family": "Liu", "given": "Qin", "initials": "Q"}, {"family": "Long", "given": "Qian", "initials": "Q"}, {"family": "Oburu", "given": "Paul", "initials": "P"}, {"family": "Pastorelli", "given": "Concetta", "initials": "C"}, {"family": "Sorbring", "given": "Emma", "initials": "E"}, {"family": "Steinberg", "given": "Laurence", "initials": "L"}, {"family": "Tapanya", "given": "Sombat", "initials": "S"}, {"family": "Uribe Tirado", "given": "Liliana Maria", "initials": "LM"}, {"family": "Yotanyamaneewong", "given": "Saengduean", "initials": "S"}, {"family": "Alampay", "given": "Liane Pe\u00f1a", "initials": "LP"}, {"family": "Al-Hassan", "given": "Suha M", "initials": "SM"}, {"family": "Bacchini", "given": "Dario", "initials": "D"}, {"family": "Bornstein", "given": "Marc H", "initials": "MH"}], "type": "journal article", "published": "2021-12-13", "journal": {"title": "Dev Psychopathol", "issn": "1469-2198", "pages": "1-16", "issn-l": null}, "abstract": "Prior to the COVID-19 pandemic, adolescents (N = 1,330; Mages = 15 and 16; 50% female), mothers, and fathers from nine countries (China, Colombia, Italy, Jordan, Kenya, Philippines, Sweden, Thailand, United States) reported on adolescents' internalizing and externalizing problems, adolescents completed a lab-based task to assess tendency for risk-taking, and adolescents reported on their well-being. During the pandemic, participants (Mage = 20) reported on changes in their internalizing, externalizing, and substance use compared to before the pandemic. Across countries, adolescents' internalizing problems pre-pandemic predicted increased internalizing during the pandemic, and poorer well-being pre-pandemic predicted increased externalizing and substance use during the pandemic. Other relations varied across countries, and some were moderated by confidence in the government's handling of the pandemic, gender, and parents' education.", "doi": "10.1017/S0954579421001139", "pmid": "34895387", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0954579421001139"}], "notes": [], "created": "2021-12-18T18:03:30.717Z", "modified": "2021-12-18T18:03:30.766Z"}, {"entity": "publication", "iuid": "0e063f882a674f9f8044b640a8967486", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e063f882a674f9f8044b640a8967486.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e063f882a674f9f8044b640a8967486"}}, "title": "Omicron SARS-CoV-2 variant: Unique features and their impact on pre-existing antibodies.", "authors": [{"family": "Kannan", "given": "Saathvik R", "initials": "SR"}, {"family": "Spratt", "given": "Austin N", "initials": "AN"}, {"family": "Sharma", "given": "Kalicharan", "initials": "K"}, {"family": "Chand", "given": "Hitendra S", "initials": "HS"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}, {"family": "Singh", "given": "Kamal", "initials": "K"}], "type": "journal article", "published": "2021-12-13", "journal": {"title": "J Autoimmun", "issn": "1095-9157", "issn-l": null, "volume": "126", "issue": null, "pages": "102779"}, "abstract": "Severe Acute Respiratory Coronavirus (SARS-CoV-2) has been emerging in the form of different variants since its first emergence in early December 2019. A new Variant of Concern (VOC) named the Omicron variant (B.1.1.529) was reported recently. This variant has a large number of mutations in the S protein. To date, there exists a limited information on the Omicron variant. Here we present the analyses of mutation distribution, the evolutionary relationship of Omicron with previous variants, and probable structural impact of mutations on antibody binding. Our analyses show the presence of 46 high prevalence mutations specific to Omicron. Twenty-three of these are localized within the spike (S) protein and the rest localized to the other 3 structural proteins of the virus, the envelope (E), membrane (M), and nucleocapsid (N). Phylogenetic analysis showed that the Omicron is closely related to the Gamma (P.1) variant. The structural analyses showed that several mutations are localized to the region of the S protein that is the major target of antibodies, suggesting that the mutations in the Omicron variant may affect the binding affinities of antibodies to the S protein.", "doi": "10.1016/j.jaut.2021.102779", "pmid": "34915422", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Category: Omicron VoC": null}, "xrefs": [{"db": "pii", "key": "S0896-8411(21)00187-6"}], "notes": [], "created": "2021-12-18T17:45:00.563Z", "modified": "2022-01-12T20:58:21.050Z"}, {"entity": "publication", "iuid": "0aa5c8f8220e471593a756d4bc1b6241", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0aa5c8f8220e471593a756d4bc1b6241.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0aa5c8f8220e471593a756d4bc1b6241"}}, "title": "Emergence, evolution, and vaccine production approaches of SARS-CoV-2 virus: benefits of getting vaccinated and common questions.", "authors": [{"family": "Hassanin", "given": "Abdallah A", "initials": "AA"}, {"family": "Haidar Abbas Raza", "given": "Sayed", "initials": "S"}, {"family": "Ahmed Ujjan", "given": "Javed", "initials": "J"}, {"family": "Aysh ALrashidi", "given": "Ayshah", "initials": "A"}, {"family": "Sitohy", "given": "Basel M", "initials": "BM"}, {"family": "Al-Surhanee", "given": "Ameena A", "initials": "AA"}, {"family": "Saad", "given": "Ahmed M", "initials": "AM"}, {"family": "Mohamed Al-Hazani", "given": "Tahani", "initials": "T"}, {"family": "Osman Atallah", "given": "Osama", "initials": "O"}, {"family": "Al Syaad", "given": "Khalid M", "initials": "KM"}, {"family": "Ezzat Ahmed", "given": "Ahmed", "initials": "A"}, {"family": "Swelum", "given": "Ayman A", "initials": "AA"}, {"family": "El-Saadony", "given": "Mohamed T", "initials": "MT"}, {"family": "Sitohy", "given": "Mahmoud Z", "initials": "MZ"}], "type": "journal article", "published": "2021-12-13", "journal": {"title": "Saudi J Biol Sci", "issn": "1319-562X", "issn-l": null}, "abstract": "The emergence of coronavirus disease 2019 (COVID-19) pandemic in Wuhan city, China at the end of 2019 made it urgent to identify the origin of the causal pathogen and its molecular evolution, to appropriately design an effective vaccine. This study analyzes the evolutionary background of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or SARS-2) in accordance with its close relative SARS-CoV (SARS-1), which was emerged in 2002. A comparative genomic and proteomic study was conducted on SARS-2, SARS-1, and Middle East respiratory syndrome coronavirus (MERS), which was emerged in 2012. In silico analysis inferred the genetic variability among the tested viruses. The SARS-1 genome harbored 11 genes encoding 12 proteins, while SARS-2 genome contained only 10 genes encoding for 10 proteins. MERS genome contained 11 genes encoding 11 proteins. The analysis also revealed a slight variation in the whole genome size of SARS-2 comparing to its siblings resulting from sequential insertions and deletions (indels) throughout the viral genome particularly ORF1AB, spike, ORF10 and ORF8. The effective indels were observed in the gene encoding the spike protein that is responsible for viral attachment to the angiotensin-converting enzyme 2 (ACE2) cell receptor and initiating infection. These indels are responsible for the newly emerging COVID-19 variants \u03b1CoV, \u03b2CoV, \u03b3CoV and \u03b4CoV. Nowadays, few effective COVID-19 vaccines developed based on spike (S) glycoprotein were approved and become available worldwide. Currently available vaccines can relatively prevent the spread of COVID-19 and suppress the disease. The traditional (killed or attenuated virus vaccine and antibody-based vaccine) and innovated vaccine production technologies (RNA- and DNA-based vaccines and viral vectors) are summarized in this review. We finally highlight the most common questions related to COVID-19 disease and the benefits of getting vaccinated.", "doi": "10.1016/j.sjbs.2021.12.020", "pmid": "34924802", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1319-562X(21)01053-6"}, {"db": "pmc", "key": "PMC8667566"}], "notes": [], "created": "2022-01-03T15:21:37.660Z", "modified": "2022-01-03T15:21:51.284Z"}, {"entity": "publication", "iuid": "92a3a47c712744c8956a96910197caf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/92a3a47c712744c8956a96910197caf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/92a3a47c712744c8956a96910197caf3"}}, "title": "Clinical presentation and disease course in patients with flu-like illness: does microbiological aetiology matter?", "authors": [{"family": "Verheij", "given": "Theo", "initials": "T"}, {"family": "Cianci", "given": "Daniela", "initials": "D"}, {"family": "van der Velden", "given": "Alike", "initials": "A"}, {"family": "Butler", "given": "Christopher C", "initials": "CC"}, {"family": "Bongard", "given": "Emily", "initials": "E"}, {"family": "Coenen", "given": "Samuel", "initials": "S"}, {"family": "Colliers", "given": "Annelies", "initials": "A"}, {"family": "Francis", "given": "Nick", "initials": "N"}, {"family": "Little", "given": "Paul", "initials": "P"}, {"family": "Godycki-Cwirko", "given": "Maciek", "initials": "M"}, {"family": "Llor", "given": "Carl", "initials": "C"}, {"family": "Chlabicz", "given": "Slawomir", "initials": "S"}, {"family": "Lionis", "given": "Christos", "initials": "C"}, {"family": "Sundvall", "given": "P\u00e4r-Daniel", "initials": "PD"}, {"family": "Bjerrum", "given": "Lars", "initials": "L"}, {"family": "De Sutter", "given": "An", "initials": "A"}, {"family": "Aabenhus", "given": "Rune", "initials": "R"}, {"family": "Jonassen Harbin", "given": "Nicolay", "initials": "N"}, {"family": "Lindbaek", "given": "Morten", "initials": "M"}, {"family": "Glinz", "given": "Dominik", "initials": "D"}, {"family": "Bucher", "given": "Heiner", "initials": "H"}, {"family": "Kovacs", "given": "Bernadett", "initials": "B"}, {"family": "Seifert", "given": "Bohumil", "initials": "B"}, {"family": "Touboul Lundgren", "given": "Pia", "initials": "P"}, {"family": "de Paor", "given": "Muireann", "initials": "M"}, {"family": "Radzeviciene JUrgute", "given": "Ruta", "initials": "R"}, {"family": "Matheeussen", "given": "Veerle", "initials": "V"}, {"family": "Goossens", "given": "Herman", "initials": "H"}, {"family": "Ieven", "given": "Margareta", "initials": "M"}], "type": "journal article", "published": "2021-12-13", "journal": {"title": "Br J Gen Pract", "issn": "1478-5242", "issn-l": null}, "abstract": "There is little evidence about the relation between aetiology, illness severity and clinical course of respiratory tract infections (RTI) in primary care. Understanding these associations would aid to develop effective management strategies for these infections.\n\nTo investigate whether the clinical presentation and illness course differ between RTI in whom a viral pathogen was detected and those in whom a potential bacterial pathogen was found.\n\nPost hoc analysis of data from a pragmatic randomised trial on the effects of oseltamivir in patients with influenza-like illness (ILI) in primary care (n=3266) in 15 European countries.\n\nPatient characteristics, signs and symptoms were registered at baseline. Naso-pharyngeal (adults) or nasal and pharyngeal (children) swabs were taken for PCR analysis. Patients were followed up until 28 days after inclusion. Regression models and Kaplan-Meier curves were used to analyse the relation between aetiology, clinical presentation at baseline and course of disease including complications.\n\nExcept for a less prominent congested nose (OR 0.55, CI 0.35 - 0.86) and acute cough (OR 0.52, CI 0.27 - 0.65) in ILI patients in whom a possible bacterial pathogen was isolated, there were no clear clinical differences in presentations between those with a possible bacterial aetiology than in those with a viral one. Also the course of disease and complications were not related to aetiology.\n\nGiven the currently available microbiological tests and antimicrobial treatments, and outside pandemics like COVID-19, microbiological testing in primary care patients with ILI seems to have limited value.", "doi": "10.3399/BJGP.2021.0344", "pmid": "34990385", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "BJGP.2021.0344"}], "notes": [], "created": "2022-01-10T15:32:25.010Z", "modified": "2022-01-10T15:33:16.872Z"}, {"entity": "publication", "iuid": "8a4515a6f1e84870b7936c53b3260746", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a4515a6f1e84870b7936c53b3260746.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a4515a6f1e84870b7936c53b3260746"}}, "title": "COVID-19 pandemic and the great impulse to telemedicine: the basis of the WONCA Europe Statement on Telemedicine at the WHO Europe 70th Regional Meeting September 2020.", "authors": [{"family": "Petrazzuoli", "given": "Ferdinando", "initials": "F", "orcid": "0000-0003-1058-492X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50bb7fdd235f46629be48fdff0a5fd6c.json"}}, {"family": "Kurpas", "given": "Donata", "initials": "D"}, {"family": "Vinker", "given": "Shlomo", "initials": "S"}, {"family": "Sarkisova", "given": "Valentina", "initials": "V"}, {"family": "Eleftheriou", "given": "Androulla", "initials": "A"}, {"family": "\u017bakowicz", "given": "Anna", "initials": "A", "orcid": "0000-0001-9658-8918", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/047c309284f143e8a5fd0e1103a53a1b.json"}}, {"family": "Aarendonk", "given": "Diederik", "initials": "D", "orcid": "0000-0002-8973-5446", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f2df4a7937fa4833a73389b2a420a730.json"}}, {"family": "Ungan", "given": "Mehmet", "initials": "M", "orcid": "0000-0002-6078-2177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5017979702474b50820ef5d65bb10433.json"}}], "type": "journal article", "published": "2021-12-13", "journal": {"title": "Prim Health Care Res Dev", "issn": "1477-1128", "volume": "22", "pages": "e80", "issn-l": null}, "abstract": "Telemedicine is the use of telecommunication and information technologies to support the delivery of healthcare at a distance, guaranteeing patients healthcare by facilitating access where barriers exist; the COVID-19 pandemic has attracted worldwide interest in this field.The purpose of this paper is to highlight the main pros and cons of telemedicine, which serve as the basis of the WONCA Europe Statement at the WHO Europe 70th Regional Meeting on 14 September 2020.Pros of telemedicine include virtual healthcare at home, where patients receive support in certain conditions without leaving their houses. During a pandemic, it can be adopted to limit physical human interaction. Unfortunately, it can negatively affect the quality of the doctor-patient relationship, the quality of the physical examination, and the quality of care. Telemedicine requires effective infrastructure and robust investments to be feasible and effective.", "doi": "10.1017/S1463423621000633", "pmid": "34895388", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1463423621000633"}], "notes": [], "created": "2021-12-18T18:03:07.295Z", "modified": "2021-12-18T18:03:07.462Z"}, {"entity": "publication", "iuid": "15e8d389e07a4f74905c650a0fbe6b30", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15e8d389e07a4f74905c650a0fbe6b30.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15e8d389e07a4f74905c650a0fbe6b30"}}, "title": "Mental health indicators in Sweden over a 12-month period during the COVID-19 pandemic", "authors": [{"family": "Lovik", "given": "Anik\u00f3", "initials": "A", "orcid": "0000-0002-6397-5011", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e50d5a79a1234cd79b22ec2eebf6f410.json"}}, {"family": "Gonz\u00e1lez-Hij\u00f3n", "given": "Juan", "initials": "J", "orcid": "0000-0002-3354-6697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/035df95b22194d599ab916c363018cb0.json"}}, {"family": "K\u00e4hler", "given": "Anna K", "initials": "AK", "orcid": "0000-0003-4047-4588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6d52ec01645417eb73e2bfe6c3106bd.json"}}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA", "orcid": "0000-0001-5382-946X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87d1dbec7c6f4942b1db2b999eeb9ece.json"}}, {"family": "Frans", "given": "Emma M", "initials": "EM", "orcid": "0000-0002-9791-687X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/157f412416124221ab8387bfaee3b75b.json"}}, {"family": "Magnusson", "given": "Patrik K E", "initials": "PKE"}, {"family": "Pedersen", "given": "Nancy L", "initials": "NL", "orcid": "0000-0001-8057-3543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d52d7b52d5d44febc084912148555d2.json"}}, {"family": "Hall", "given": "Per", "initials": "P", "orcid": "0000-0002-5640-9126", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36cad09fa55242b38353f6cc9081e65d.json"}}, {"family": "Czene", "given": "Kamila", "initials": "K", "orcid": "0000-0002-3233-5695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43c2cbe995a64134bc53e1c57800d798.json"}}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF", "orcid": "0000-0002-6619-873X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f9632d685f348cea7a69ebfe51ad0ab.json"}}, {"family": "Fang", "given": "Fang", "initials": "F", "orcid": "0000-0002-3310-6456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b0852465cd14239a25329b976172792.json"}}], "type": "posted-content", "published": "2021-12-11", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.12.10.21267338", "pmid": null, "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Preprint": null, "Funder: NordForsk": null}, "xrefs": [], "notes": [], "created": "2023-02-13T18:39:39.428Z", "modified": "2023-10-04T08:18:19.334Z"}, {"entity": "publication", "iuid": "6b238744a79b413380ea8cb666d8ea3e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b238744a79b413380ea8cb666d8ea3e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b238744a79b413380ea8cb666d8ea3e"}}, "title": "Immunogenicity after six months of BNT162b2 vaccination in frail or disabled nursing home residents: the COVID\u2010A Study", "authors": [{"family": "R\u00edos", "given": "Sergio Salmer\u00f3n", "initials": "SS"}, {"family": "Zamora", "given": "Elisa Bel\u00e9n Cort\u00e9s", "initials": "EBC"}, {"family": "C\u00e9spedes", "given": "Almudena Avenda\u00f1o", "initials": "AA"}, {"family": "Rizos", "given": "Luis Romero", "initials": "LR"}, {"family": "S\u00e1nchez\u2010Jurado", "given": "Pedro Manuel", "initials": "PM"}, {"family": "S\u00e1nchez\u2010Nievas", "given": "Gin\u00e9s", "initials": "G"}, {"family": "Romero", "given": "Marta Mas", "initials": "MM"}, {"family": "Tabernero Sahuquillo", "given": "Mar\u00eda Teresa", "initials": "MT"}, {"family": "Se\u00f1alada", "given": "Jos\u00e9 Joaqu\u00edn Blas", "initials": "JJB"}, {"family": "Romero", "given": "Antonio Murillo", "initials": "AM"}, {"family": "Nogueras", "given": "Inmaculada Garc\u00eda", "initials": "IG"}, {"family": "Dios Estrella Cazalla", "given": "Juan", "initials": "J"}, {"family": "Andr\u00e9s\u2010Pretel", "given": "Fernando", "initials": "F"}, {"family": "Lauschke", "given": "Volker Martin", "initials": "VM"}, {"family": "Stebbing", "given": "Justin", "initials": "J"}, {"family": "Abizanda", "given": "Pedro", "initials": "P", "orcid": "0000-0002-4707-2963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed9e8a3fed5842cd9ad7d5653b85c4a1.json"}}], "type": "journal-article", "published": "2021-12-11", "journal": {"title": "J Am Geriatr Soc", "issn": "0002-8614", "issn-l": null}, "abstract": null, "doi": "10.1111/jgs.17620", "pmid": null, "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:45:43.140Z", "modified": "2021-12-12T06:45:43.166Z"}, {"entity": "publication", "iuid": "ce55eff25b8f4e148e130386faafb114", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ce55eff25b8f4e148e130386faafb114.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ce55eff25b8f4e148e130386faafb114"}}, "title": "The profile of the COvid-19 VACcination register SAFEty study in Sweden (CoVacSafe-SE).", "authors": [{"family": "Ljung", "given": "Rickard", "initials": "R"}, {"family": "Sundstr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Gr\u00fcnewald", "given": "Maria", "initials": "M"}, {"family": "Backman", "given": "Charlotte", "initials": "C"}, {"family": "Feltelius", "given": "Nils", "initials": "N"}, {"family": "Gedeborg", "given": "Rolf", "initials": "R"}, {"family": "Zethelius", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2021-12-10", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "volume": "126", "issn-l": "0300-9734"}, "abstract": "The coronavirus disease 2019 (COVID-19) vaccines have been rapidly implemented in national vaccination programs world-wide after accelerated approval processes. The large population exposure achieved in very short time requires systematic monitoring of safety. The Swedish Medical Products Agency has launched a project platform for epidemiological surveillance to detect and characterise suspected adverse effects of COVID-19 vaccines in Sweden.\n\nThe platform includes all individuals 12 years or older in Sweden in 2021 and will be updated annually. Data, including vaccine and COVID-19 disease data, socioeconomic and demographic data, comorbidity, prescribed medicines and healthcare utilisation outcomes, are obtained from several national registers in collaboration with other Swedish Government agencies. Data from 2015 to 2019 are used as a historical comparison cohort unexposed to both the COVID-19 pandemic and to the COVID-19 vaccines.\n\nThe primary study cohort includes 8,305,978 adults 18 years and older permanently residing in Sweden on 31 December 2020. The historical control cohort includes 8,679,641 subjects. By 31 July 2021, around 50% of those 18 years and older and two-thirds of those 50 years and older were vaccinated with at least one dose, 90% of those 70 years or older had two doses.\n\nThe nationwide register-based study cohort created by the Swedish Medical Products Agency with regular updates of individual level linkage of COVID-19 vaccination exposure data to other health data registers will facilitate both safety signal detection and evaluation and other pharmacoepidemiological studies.", "doi": "10.48101/ujms.v126.8136", "pmid": "34984096", "labels": {"Category: Vaccines": null, "Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC8693580"}, {"db": "pii", "key": "8136"}], "notes": [], "created": "2022-01-10T15:34:26.263Z", "modified": "2023-01-13T13:39:24.450Z"}, {"entity": "publication", "iuid": "e629e0b88f764cb6a5e5e0616bead01b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e629e0b88f764cb6a5e5e0616bead01b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e629e0b88f764cb6a5e5e0616bead01b"}}, "title": "Safeguarding people living in vulnerable conditions in the COVID-19 era through universal health coverage and social protection.", "authors": [{"family": "Barron", "given": "Gabriela Cuevas", "initials": "GC"}, {"family": "Laryea-Adjei", "given": "George", "initials": "G"}, {"family": "Vike-Freiberga", "given": "Vaira", "initials": "V"}, {"family": "Abubakar", "given": "Ibrahim", "initials": "I"}, {"family": "Dakkak", "given": "Henia", "initials": "H"}, {"family": "Devakumar", "given": "Delanjathan", "initials": "D"}, {"family": "Johnsson", "given": "Anders", "initials": "A"}, {"family": "Karabey", "given": "Selma", "initials": "S"}, {"family": "Labont\u00e9", "given": "Ronald", "initials": "R"}, {"family": "Legido-Quigley", "given": "Helena", "initials": "H"}, {"family": "Lloyd-Sherlock", "given": "Peter", "initials": "P"}, {"family": "Olufadewa", "given": "Isaac Iyinoluwa", "initials": "II"}, {"family": "Ray", "given": "Harold Calvin", "initials": "HC"}, {"family": "Redlener", "given": "Irwin", "initials": "I"}, {"family": "Redlener", "given": "Karen", "initials": "K"}, {"family": "Serageldin", "given": "Ismail", "initials": "I"}, {"family": "Lima", "given": "Nisia Trindade", "initials": "NT"}, {"family": "Viana", "given": "Virgilio", "initials": "V"}, {"family": "Zappone", "given": "Katherine", "initials": "K"}, {"family": "Huynh", "given": "Uyen Kim", "initials": "UK"}, {"family": "Schlosberg", "given": "Nicole", "initials": "N"}, {"family": "Sun", "given": "Hanlu", "initials": "H"}, {"family": "Karadag", "given": "Ozge", "initials": "O"}, {"family": "Lancet Commission on COVID-19: Task Force on Humanitarian Relief, Social Protection and Vulnerable Groups", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-10", "journal": {"title": "Lancet Public Health", "issn": "2468-2667", "issn-l": null}, "abstract": "The COVID-19 pandemic is unprecedented. The pandemic not only induced a public health crisis, but has led to severe economic, social, and educational crises. Across economies and societies, the distributional consequences of the pandemic have been uneven. Among groups living in vulnerable conditions, the pandemic substantially magnified the inequality gaps, with possible negative implications for these individuals' long-term physical, socioeconomic, and mental wellbeing. This Viewpoint proposes priority, programmatic, and policy recommendations that governments, resource partners, and relevant stakeholders should consider in formulating medium-term to long-term strategies for preventing the spread of COVID-19, addressing the virus's impacts, and decreasing health inequalities. The world is at a never more crucial moment, requiring collaboration and cooperation from all sectors to mitigate the inequality gaps and improve people's health and wellbeing with universal health coverage and social protection, in addition to implementation of the health in all policies approach.", "doi": "10.1016/S2468-2667(21)00235-8", "pmid": "34906331", "labels": {"Type: Review": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2468-2667(21)00235-8"}, {"db": "pmc", "key": "PMC8665842"}], "notes": [], "created": "2021-12-18T17:54:05.429Z", "modified": "2021-12-18T17:54:05.441Z"}, {"entity": "publication", "iuid": "57212c7f13c042b986a0532a73c0e0c1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/57212c7f13c042b986a0532a73c0e0c1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/57212c7f13c042b986a0532a73c0e0c1"}}, "title": "Infectious complications and vaccines", "authors": [{"family": "Ljungman", "given": "Per", "initials": "P"}], "type": "journal-article", "published": "2021-12-10", "journal": {"issn": "1520-4391", "volume": "2021", "issue": "1", "pages": "587-591", "issn-l": null}, "abstract": null, "doi": "10.1182/hematology.2021000294", "pmid": null, "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:51:52.783Z", "modified": "2021-12-12T06:51:52.898Z"}, {"entity": "publication", "iuid": "0a34a24ce00441bc96f56bc382e194e3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a34a24ce00441bc96f56bc382e194e3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a34a24ce00441bc96f56bc382e194e3"}}, "title": "The Depression: Online Therapy Study (D:OTS)-A Pilot Study of an Internet-Based Psychodynamic Treatment for Adolescents with Low Mood in the UK, in the Context of the COVID-19 Pandemic.", "authors": [{"family": "Midgley", "given": "Nick", "initials": "N"}, {"family": "Guerrero-Tates", "given": "Brenda", "initials": "B", "orcid": "0000-0001-6329-7444", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b32ab4ed632f47f9863ccc50421e02c1.json"}}, {"family": "Mortimer", "given": "Rose", "initials": "R"}, {"family": "Edbrooke-Childs", "given": "Julian", "initials": "J"}, {"family": "Mechler", "given": "Jakob", "initials": "J", "orcid": "0000-0002-1296-3432", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69054a3745b04d12b759a754b88148c7.json"}}, {"family": "Lindqvist", "given": "Karin", "initials": "K"}, {"family": "Hajkowski", "given": "Susan", "initials": "S"}, {"family": "Leibovich", "given": "Liat", "initials": "L"}, {"family": "Martin", "given": "Peter", "initials": "P", "orcid": "0000-0003-4638-0638", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f85a19380ba34972a839e5453514ae65.json"}}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Vlaescu", "given": "George", "initials": "G"}, {"family": "Lilliengren", "given": "Peter", "initials": "P"}, {"family": "Kitson", "given": "Annabel", "initials": "A"}, {"family": "Butler-Wheelhouse", "given": "Pamela", "initials": "P"}, {"family": "Philips", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2021-12-09", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "24", "issn-l": null}, "abstract": "Introduction: Face-to-face therapy is unavailable to many young people with mental health difficulties in the UK. Internet-based treatments are a low-cost, flexible, and accessible option that may be acceptable to young people. This pilot study examined the feasibility, acceptability and effectiveness of an English-language adaptation of internet-based psychodynamic treatment (iPDT) for depressed adolescents, undertaken during the COVID-19 pandemic in the UK. Methods: A single-group, uncontrolled design was used. A total of 23 adolescents, 16-18 years old and experiencing depression, were recruited to this study. Assessments were made at baseline and end of treatment, with additional weekly assessments of depression and anxiety symptoms. Results: Findings showed that it was feasible to recruit to this study during the pandemic, and to deliver the iPDT model with a good level of treatment acceptability. A statistically significant reduction in depressive symptoms and emotion dysregulation was found, with large effect size, by the end of treatment. Whilst anxiety symptoms decreased, this did not reach statistical significance. Conclusions: The findings suggest that this English-language adaptation of iPDT, with some further revisions, is feasible to deliver and acceptable for adolescents with depression. Preliminary data indicate that iPDT appears to be effective in reducing depressive symptoms in adolescents.", "doi": "10.3390/ijerph182412993", "pmid": "34948601", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182412993"}, {"db": "pmc", "key": "PMC8702018"}], "notes": [], "created": "2022-01-04T15:31:18.484Z", "modified": "2022-01-04T15:31:26.495Z"}, {"entity": "publication", "iuid": "75c2e73874374773acdbf004d6dba2a8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/75c2e73874374773acdbf004d6dba2a8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/75c2e73874374773acdbf004d6dba2a8"}}, "title": "Surveillance of COVID-19 vaccine effectiveness \u2013 a real-time case-control study in southern Sweden", "authors": [{"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J", "orcid": "0000-0003-1883-2000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e88fdca336ae41c891f0a46e2481b67f.json"}}, {"family": "Bonander", "given": "Carl", "initials": "C", "orcid": "0000-0002-1189-9950", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/386ac82b1a4843828b503ec807c08206.json"}}, {"family": "Moghaddassi", "given": "Mahnaz", "initials": "M", "orcid": "0000-0002-0844-4736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a219bde5ba8a4f3f8655ada08d749885.json"}}, {"family": "Rasmussen", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1588-5473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c760e8d21ae441ba236f86e6185d392.json"}}, {"family": "Malmqvist", "given": "Ulf", "initials": "U"}, {"family": "Kahn", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-5566-6350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42eda71f3775400599febc10a4e7359c.json"}}, {"family": "Inghammar", "given": "Malin", "initials": "M", "orcid": "0000-0003-2995-1312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4ab710428614cccb2a537ecab31d0a0.json"}}], "type": "posted-content", "published": "2021-12-09", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.12.09.21267515", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:47:57.738Z", "modified": "2022-01-04T15:47:57.811Z"}, {"entity": "publication", "iuid": "2c51df9483e84e5582c25da75f2caf02", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c51df9483e84e5582c25da75f2caf02.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c51df9483e84e5582c25da75f2caf02"}}, "title": "Indirect effects of COVID-19 on the environment: How deep and how long?", "authors": [{"family": "Vadiati", "given": "Meysam", "initials": "M"}, {"family": "Beynaghi", "given": "Ali", "initials": "A"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Bandala", "given": "Erick R", "initials": "ER"}, {"family": "Mozafari", "given": "Masoud", "initials": "M"}], "type": "journal article", "published": "2021-12-09", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "pages": "152255", "issn-l": "0048-9697"}, "abstract": "Although the World Health Organization (WHO) announcement released in early March 2020 stated there is no proven evidence that the COVID-19 virus can survive in drinking water or sewage, there has been some recent evidence that coronaviruses can survive in low-temperature environments and in groundwater for more than a week. Some studies have also found SARS-CoV-2 genetic materials in raw municipal wastewater, which highlights a potential avenue for viral spread. A lack of information about the presence and spread of COVID-19 in the environment may lead to decisions based on local concerns and prevent the integration of the prevalence of SARS-CoV-2 into the global water cycle. Several studies have optimistically assumed that coronavirus has not yet affected water ecosystems, but this assumption may increase the possibility of subsequent global water issues. More studies are needed to provide a comprehensive picture of COVID-19 occurrence and outbreak in aquatic environments and more specifically in water resources. As scientific efforts to report reliable news, conduct rapid and precise research on COVID-19, and advocate for scientists worldwide to overcome this crisis increase, more information is required to assess the extent of the effects of the COVID-19 pandemic on the environment. The goals of this study are to estimate the extent of the environmental effects of the pandemic, as well as identify related knowledge gaps and avenues for future research.", "doi": "10.1016/j.scitotenv.2021.152255", "pmid": "34896489", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(21)07331-9"}, {"db": "pmc", "key": "PMC8660132"}], "notes": [], "created": "2021-12-18T18:02:36.372Z", "modified": "2021-12-18T18:02:36.384Z"}, {"entity": "publication", "iuid": "9f7d2dc2f2ba4d5f814c6b9181f721b6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f7d2dc2f2ba4d5f814c6b9181f721b6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f7d2dc2f2ba4d5f814c6b9181f721b6"}}, "title": "Increasing risk of breakthrough COVID-19 in outbreaks with high attack rates in European long-term care facilities, July to October 2021", "authors": [{"family": "Suetens", "given": "Carl", "initials": "C"}, {"family": "Kinross", "given": "Pete", "initials": "P"}, {"family": "Gallego Berciano", "given": "Pilar", "initials": "P"}, {"family": "Arroyo Nebreda", "given": "Virginia", "initials": "V"}, {"family": "Hassan", "given": "Eline", "initials": "E"}, {"family": "Calba", "given": "Cl\u00e9mentine", "initials": "C"}, {"family": "Fernandes", "given": "Eugenia", "initials": "E"}, {"family": "Peralta-Santos", "given": "Andre", "initials": "A"}, {"family": "Casaca", "given": "Pedro", "initials": "P"}, {"family": "Shodu", "given": "Nathalie", "initials": "N"}, {"family": "Dequeker", "given": "Sara", "initials": "S"}, {"family": "Kontopidou", "given": "Flora", "initials": "F"}, {"family": "Pappa", "given": "Lamprini", "initials": "L"}, {"family": "Kacelnik", "given": "Oliver", "initials": "O"}, {"family": "B\u00f8rseth", "given": "Anita Wang", "initials": "AW"}, {"family": "O\u2019Connor", "given": "Lois", "initials": "L"}, {"family": "Garvey", "given": "Patricia", "initials": "P"}, {"family": "Liausedien\u0117", "given": "Rasa", "initials": "R"}, {"family": "Valintelien\u0117", "given": "Rolanda", "initials": "R"}, {"family": "Ernst", "given": "Corinna", "initials": "C"}, {"family": "Mossong", "given": "Jo\u00ebl", "initials": "J"}, {"family": "\u0160tefkovi\u010dov\u00e1", "given": "M\u00e1ria", "initials": "M"}, {"family": "Prostin\u00e1kov\u00e1", "given": "Zuzana", "initials": "Z"}, {"family": "Danielsen", "given": "Ann Caroline", "initials": "AC"}, {"family": "Mougkou", "given": "Aikaterini", "initials": "A"}, {"family": "Lamb", "given": "Favelle", "initials": "F"}, {"family": "Cenciarelli", "given": "Orlando", "initials": "O"}, {"family": "Monnet", "given": "Dominique L", "initials": "DL"}, {"family": "Plachouras", "given": "Diamantis", "initials": "D"}], "type": "journal-article", "published": "2021-12-09", "journal": {"issn": "1560-7917", "volume": "26", "issue": "49", "title": "Euro Surveill", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.es.2021.26.49.2101070", "pmid": null, "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:55:12.065Z", "modified": "2021-12-12T06:55:12.078Z"}, {"entity": "publication", "iuid": "50574c4460054f4bac0c05e7f605b4f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50574c4460054f4bac0c05e7f605b4f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50574c4460054f4bac0c05e7f605b4f7"}}, "title": "Autoantibodies and infection with SARS-CoV2 infection: The spectrum from association to clinical implicationreport of the 15th Dresden symposium on autoantibodies.", "authors": [{"family": "Damoiseaux", "given": "Jan", "initials": "J"}, {"family": "Dotan", "given": "Arad", "initials": "A"}, {"family": "Fritzler", "given": "Marvin J", "initials": "MJ"}, {"family": "Bogdanos", "given": "Dimitrios P", "initials": "DP"}, {"family": "Meroni", "given": "Pier Luigi", "initials": "PL"}, {"family": "Roggenbuck", "given": "Dirk", "initials": "D"}, {"family": "Goldman", "given": "Michel", "initials": "M"}, {"family": "Landegren", "given": "Nils", "initials": "N"}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Shoenfeld", "given": "Yehuda", "initials": "Y"}, {"family": "Conrad", "given": "Karsten", "initials": "K"}], "type": "journal article", "published": "2021-12-09", "journal": {"title": "Autoimmun Rev", "issn": "1873-0183", "pages": "103012", "issn-l": null}, "abstract": "The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Symposium on Autoantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting.", "doi": "10.1016/j.autrev.2021.103012", "pmid": "34896650", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1568-9972(21)00294-9"}, {"db": "pmc", "key": "PMC8656211"}], "notes": [], "created": "2021-12-18T18:01:27.322Z", "modified": "2021-12-18T18:01:36.807Z"}, {"entity": "publication", "iuid": "ea1e1a34cf7d4dabbd5a5918e7571cbd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ea1e1a34cf7d4dabbd5a5918e7571cbd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ea1e1a34cf7d4dabbd5a5918e7571cbd"}}, "title": "Convalescent plasma treatment in severely immunosuppressed patients hospitalized with COVID-19: an observational study of 28 cases.", "authors": [{"family": "Ljungquist", "given": "Oskar", "initials": "O"}, {"family": "Lundgren", "given": "Maria", "initials": "M"}, {"family": "Iliachenko", "given": "Elena", "initials": "E"}, {"family": "M\u00e5nsson", "given": "Fredrik", "initials": "F"}, {"family": "B\u00f6ttiger", "given": "Blenda", "initials": "B"}, {"family": "Landin-Olsson", "given": "Mona", "initials": "M"}, {"family": "Wik\u00e9n", "given": "Christian", "initials": "C"}, {"family": "Rosendal", "given": "Ebba", "initials": "E"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "Wigren", "given": "Bystr\u00f6m J", "initials": "BJ"}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE"}, {"family": "Kjeldsen-Kragh", "given": "Jens", "initials": "J"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1588-5473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c760e8d21ae441ba236f86e6185d392.json"}}, {"family": "Kahn", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-5566-6350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42eda71f3775400599febc10a4e7359c.json"}}, {"family": "Holm", "given": "Karin", "initials": "K", "orcid": "0000-0002-8289-5949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7f590df41084ab28d7a1ac80b1b90e7.json"}}], "type": "journal article", "published": "2021-12-08", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "pages": "1-9", "issn-l": "2374-4235"}, "abstract": "Immunosuppressed patients are particularly vulnerable to severe infection from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), risking prolonged viremia and symptom duration. In this study we describe clinical and virological treatment outcomes in a heterogeneous group of patients with severe immunosuppression due to various causes suffering from COVID-19 infection, who were all treated with convalescent plasma (CCP) along with standard treatment.\n\nWe performed an observational, retrospective case series between May 2020 to March 2021 at three sites in Sk\u00e5ne, Sweden, with a population of nearly 1.4 million people. All patients hospitalized for COVID-19 who received CCP with the indication severe immunosuppression as defined by the treating physician were included in the study (n = 28).\n\nIn total, 28 severely immunocompromised patients, half of which previously had been treated with rituximab, who had received in-hospital convalescent plasma treatment of COVID-19 were identified. One week after CCP treatment, 13 of 28 (46%) patients had improved clinically defined as a decrease of at least one point at the WHO-scale. Three patients had increased score points of whom two had died. For 12 patients, the WHO-scale was unchanged.\n\nAs one of only few studies on CCP treatment of COVID-19 in hospitalized patients with severe immunosuppression, this study adds descriptive data. The study design prohibits conclusions on safety and efficacy, and the results should be interpreted with caution. Prospective, randomized trials are needed to investigate this further.", "doi": "10.1080/23744235.2021.2013528", "pmid": "34878955", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-12T07:15:43.946Z", "modified": "2021-12-12T07:15:44.023Z"}, {"entity": "publication", "iuid": "cc31f7e80cd84d1eb9ef8e03aa706616", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc31f7e80cd84d1eb9ef8e03aa706616.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc31f7e80cd84d1eb9ef8e03aa706616"}}, "title": "What a Pandemic Has Taught Us About the Potential for Innovation in Rural Health: Commencing an Ethnography in Canada, the United States, Sweden, and Australia.", "authors": [{"family": "Petrie", "given": "Samuel", "initials": "S"}, {"family": "Carson", "given": "Dean", "initials": "D"}, {"family": "Peters", "given": "Paul", "initials": "P"}, {"family": "Hurtig", "given": "Anna-Karin", "initials": "AK"}, {"family": "LeBlanc", "given": "Michele", "initials": "M"}, {"family": "Simpson", "given": "Holly", "initials": "H"}, {"family": "Barnabe", "given": "Jaymie", "initials": "J"}, {"family": "Young", "given": "Mikayla", "initials": "M"}, {"family": "Ostafichuk", "given": "Mara", "initials": "M"}, {"family": "Hodge", "given": "Heidi", "initials": "H"}, {"family": "Gladman", "given": "Justin", "initials": "J"}, {"family": "Smale", "given": "Matilda", "initials": "M"}, {"family": "Gonzalez Garcia", "given": "Manueal", "initials": "M"}], "type": "journal article", "published": "2021-12-07", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "768624", "issn-l": "2296-2565"}, "abstract": "The COVID-19 pandemic coincided with a multi-national federally funded research project examining the potential for health and care services in small rural areas to identify and implement innovations in service delivery. The project has a strong focus on electronic health (eHealth) but covers other areas of innovation as well. The project has been designed as an ethnography to prelude a realist evaluation, asking the question under what conditions can local health and care services take responsibility for designing and implementing new service models that meet local needs? The project had already engaged with several health care practitioners and research students based in Canada, Sweden, Australia, and the United States. Our attention is particularly on rural communities with fewer than 5,000 residents and which are relatively isolated from larger service centres. Between March and September 2020, the project team undertook ethnographic and auto-ethnographic research in their own communities to investigate what the service model responses to the pandemic were, and the extent to which local service managers were able to customize their responses to suit the needs of their communities. An initial program theory drawn from the extant literature suggested that \"successful\" response to the pandemic would depend on a level of local autonomy, \"absorptive capacity,*\" strong service-community connections, an \"anti-fragile\u2020\" approach to implementing change, and a realistic recognition of the historical barriers to implementing eHealth and other innovations in these types of rural communities. The field research in 2020 has refined the theory by focusing even more attention on absorptive capacity and community connections, and by suggesting that some level of ignorance of the barriers to innovation may be beneficial. The research also emphasized the role and power of external actors to the community which had not been well-explored in the literature. This paper will summarize both what the field research revealed about the capacity to respond well to the COVID-19 challenge and highlight the gaps in innovative strategies at a managerial level required for rapid response to system stress. *Absorptive Capacity is defined as the ability of an organization (community, clinic, hospital) to adapt to change. Organizations with flexible capacity can incorporate change in a productive fashion, while those with rigid capacity take longer to adapt, and may do so inappropriately. \u2020Antifragility is defined as an entities' ability to gain stability through stress. Biological examples include building muscle through consistent use, and bones becoming stronger through subtle stress. Antifragility has been used as a guiding principle in programme implementation in the past.", "doi": "10.3389/fpubh.2021.768624", "pmid": "34950628", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8688687"}], "notes": [], "created": "2022-01-04T15:27:50.199Z", "modified": "2022-01-04T15:27:50.212Z"}, {"entity": "publication", "iuid": "052ca3e645354ab7a97015a64dd0b35e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/052ca3e645354ab7a97015a64dd0b35e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/052ca3e645354ab7a97015a64dd0b35e"}}, "title": "Training the trainers: Finding new educational opportunities in the virtual world.", "authors": [{"family": "Baessler", "given": "Franziska", "initials": "F", "orcid": "0000-0001-7280-9675", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8397969848e4bbf90e3b54df39bdb1b.json"}}, {"family": "Sartorius", "given": "Norman", "initials": "N", "orcid": "0000-0001-8708-6289", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04897447954f4336ae2d7f094bbc4571.json"}}, {"family": "Javed", "given": "Afzal", "initials": "A", "orcid": "0000-0003-2518-0688", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c17ce249596343c78ae97f5a7c68c916.json"}}, {"family": "Tasman", "given": "Allan", "initials": "A"}, {"family": "Coskun", "given": "Bulent", "initials": "B", "orcid": "0000-0002-6381-8120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba8f859894574029adfc05e94b15f5f5.json"}}, {"family": "Frydecka", "given": "Dorota", "initials": "D", "orcid": "0000-0001-8582-9958", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd965f723ffb48b283e8e318b6baba75.json"}}, {"family": "Kazakova", "given": "Olga", "initials": "O", "orcid": "0000-0003-3261-3429", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8434c5d25ce64f048f4b8b56b2ec3a9d.json"}}, {"family": "Sampogna", "given": "Gaia", "initials": "G", "orcid": "0000-0002-9547-2793", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8aa29f1af234c24b093c46f4cad7a22.json"}}, {"family": "Zhabenko", "given": "Olena", "initials": "O", "orcid": "0000-0001-7986-2970", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e133dad8f94e43b8be67aebe6af4ba3e.json"}}, {"family": "Koelkebeck", "given": "Katja", "initials": "K", "orcid": "0000-0002-0469-3997", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/63a95a4ddeca4835afd611a064d3dacf.json"}}, {"family": "Hepdurgun", "given": "Cenan", "initials": "C", "orcid": "0000-0002-2809-0277", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8bdd4d5544674a94a6418472283e5648.json"}}, {"family": "Zafar", "given": "Ali", "initials": "A", "orcid": "0000-0002-1305-7407", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3834361e7e34408890e0889c9dc6668e.json"}}, {"family": "Fiorillo", "given": "Andrea", "initials": "A", "orcid": "0000-0002-6926-0762", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89a321877c9049918b8fec9cd5b09c84.json"}}], "type": "journal article", "published": "2021-12-07", "journal": {"title": "Asia Pac Psychiatry", "issn": "1758-5872", "pages": "e12499", "issn-l": null}, "abstract": "The COVID-19 pandemic has disrupted scientific gatherings and conferences, opening up opportunities for virtual learning platforms. Realizing the potential of online academic exchanges, the World Psychiatric Association (WPA) also developed virtual avenues and information systems for capacity building of mental health professionals across the world. Among its first such initiatives, the WPA organized a virtual Train the Trainers workshop, where 123 psychiatrists, psychiatric trainees, and educators from 45 countries participated. The innovative and interactive workshop allowed participants to get to know each other, exchange educational and professional experiences, and ask questions or receive advice from experts. Keynote speakers, including WPA President Prof. Afzal Javed and Prof. Norman Sartorius, stressed upon the importance of finding innovative solutions in psychiatry training and the need to improve teaching and training in the field of psychiatry, especially in the provision of leadership and communication skills. Online training methods can provide easy access to academics and students while reducing the organizational and logistical costs. They have the potential to improve educational equality and allow the voice of the underprivileged scientists to be heard across the globe. The devastating impact on access to mental health services during COVID-19 underscores the urgent need for online training, particularly in countries where the ratio of psychiatrists to patients is inadequate and doctors concentrate more on treatment than on research and education. Virtual educational interventions could prove incredibly useful in the future just as they are being successfully utilized in local and regional contexts during the pandemic.", "doi": "10.1111/appy.12499", "pmid": "34873842", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-12-12T07:10:44.650Z", "modified": "2021-12-12T07:10:45.043Z"}, {"entity": "publication", "iuid": "8e1f894a5f5249e5961aebb3314dfbfd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e1f894a5f5249e5961aebb3314dfbfd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e1f894a5f5249e5961aebb3314dfbfd"}}, "title": "Resilience in care organisations: challenges in maintaining support for vulnerable people in Europe during the Covid-19 pandemic.", "authors": [{"family": "Orru", "given": "Kati", "initials": "K"}, {"family": "Nero", "given": "Kristi", "initials": "K"}, {"family": "Naevestad", "given": "Tor-Olav", "initials": "TO"}, {"family": "Schieffelers", "given": "Abriel", "initials": "A"}, {"family": "Olson", "given": "Alexandra", "initials": "A"}, {"family": "Airola", "given": "Merja", "initials": "M"}, {"family": "Kazemekaityte", "given": "Austeja", "initials": "A"}, {"family": "Lovasz", "given": "Gabriella", "initials": "G"}, {"family": "Scurci", "given": "Giuseppe", "initials": "G"}, {"family": "Ludvigsen", "given": "Johanna", "initials": "J"}, {"family": "de Los Rios P\u00e9rez", "given": "Daniel A", "initials": "DA"}], "type": "journal article", "published": "2021-12-07", "journal": {"title": "Disasters", "issn": "1467-7717", "issn-l": null}, "abstract": "The Covid-19 pandemic has challenged the resilience of care organisations (and those dependent on them), especially when services are stopped or restricted. This study focuses on the experiences of care organisations that offer services to individuals in highly precarious situations in 10 European countries. It is based on 32 qualitative interviews and three workshops with managers and staff. The four key types of organisations reviewed largely had the same adaptation patterns in all countries. The most drastic changes were experienced by day centres, which had to suspend or digitise services, whereas night shelters and soup kitchens had to reorganise broadly their work; residential facilities were minimally affected. Given the drastic surge in demand for services, reliance on an overburdened (volunteer) workforce, and a lack of crisis plans, the care organisations with long-term trust networks with clients and intra-organisational cooperation adapted easier. The outcomes were worse for new clients, migrants, psychologically vulnerable people, and those with limited communicative abilities.", "doi": "10.1111/disa.12526", "pmid": "34874082", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-12-12T07:11:20.679Z", "modified": "2021-12-12T07:11:36.858Z"}, {"entity": "publication", "iuid": "a9889a45330745ef9afbcd594c736357", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a9889a45330745ef9afbcd594c736357.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a9889a45330745ef9afbcd594c736357"}}, "title": "Plasma Proteome Fingerprints Reveal Distinctiveness and Clinical Outcome of SARS-CoV-2 Infection.", "authors": [{"family": "Bauer", "given": "Wolfgang", "initials": "W", "orcid": "0000-0002-1063-3237", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae14a94fec6e47a58fb0571d872eb474.json"}}, {"family": "Weber", "given": "Marcus", "initials": "M"}, {"family": "Diehl-Wiesenecker", "given": "Eva", "initials": "E"}, {"family": "Galtung", "given": "Noa", "initials": "N", "orcid": "0000-0002-4379-9516", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/afc2ffad4bff4f3bbddc701f06254b53.json"}}, {"family": "Prpic", "given": "Monika", "initials": "M"}, {"family": "Somasundaram", "given": "Rajan", "initials": "R"}, {"family": "Tauber", "given": "Rudolf", "initials": "R"}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67a59fa5de37434c8b7151039c192a37.json"}}, {"family": "Micke", "given": "Patrick", "initials": "P", "orcid": "0000-0003-1210-5961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24f9f5e6c72d414b869d2adeed4b9951.json"}}, {"family": "Kappert", "given": "Kai", "initials": "K", "orcid": "0000-0001-6976-0428", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/803023090ed64c3eb77f84a84d561c67.json"}}], "type": "journal article", "published": "2021-12-07", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "13", "issue": "12", "pages": "2456"}, "abstract": "We evaluated how plasma proteomic signatures in patients with suspected COVID-19 can unravel the pathophysiology, and determine kinetics and clinical outcome of the infection.\r\n\r\nPlasma samples from patients presenting to the emergency department (ED) with symptoms of COVID-19 were stratified into: (1) patients with suspected COVID-19 that was not confirmed (n = 44); (2) non-hospitalized patients with confirmed COVID-19 (n = 44); (3) hospitalized patients with confirmed COVID-19 (n = 53) with variable outcome; and (4) patients presenting to the ED with minor diseases unrelated to SARS-CoV-2 infection (n = 20). Besides standard of care diagnostics, 177 circulating proteins related to inflammation and cardiovascular disease were analyzed using proximity extension assay (PEA, Olink) technology.\r\n\r\nComparative proteome analysis revealed 14 distinct proteins as highly associated with SARS-CoV-2 infection and 12 proteins with subsequent hospitalization (p < 0.001). ADM, IL-6, MCP-3, TRAIL-R2, and PD-L1 were each predictive for death (AUROC curve 0.80-0.87). The consistent increase of these markers, from hospital admission to intensive care and fatality, supported the concept that these proteins are of major clinical relevance.\r\n\r\nWe identified distinct plasma proteins linked to the presence and course of COVID-19. These plasma proteomic findings may translate to a protein fingerprint, helping to assist clinical management decisions.", "doi": "10.3390/v13122456", "pmid": "34960725", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Drug discovery and repurposing of drugs": null}, "xrefs": [{"db": "pii", "key": "v13122456"}, {"db": "pmc", "key": "PMC8706135"}], "notes": [], "created": "2021-12-18T18:26:19.356Z", "modified": "2022-01-04T15:50:46.848Z"}, {"entity": "publication", "iuid": "2fe18e9c5e8a46e291d0c66359a4a8f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2fe18e9c5e8a46e291d0c66359a4a8f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2fe18e9c5e8a46e291d0c66359a4a8f8"}}, "title": "Imiquimod Boosts Interferon Response, and Decreases ACE2 and Pro-Inflammatory Response of Human Bronchial Epithelium in Asthma.", "authors": [{"family": "Nieto-Fontarigo", "given": "Juan Jos\u00e9", "initials": "JJ"}, {"family": "Tillgren", "given": "Sofia", "initials": "S"}, {"family": "Cerps", "given": "Samuel", "initials": "S"}, {"family": "Sverrild", "given": "Asger", "initials": "A"}, {"family": "Hvidtfeldt", "given": "Morten", "initials": "M"}, {"family": "Ramu", "given": "Sangeetha", "initials": "S"}, {"family": "Menzel", "given": "Mandy", "initials": "M"}, {"family": "Sander", "given": "Adam Frederik", "initials": "AF"}, {"family": "Porsbjerg", "given": "Celeste", "initials": "C"}, {"family": "Uller", "given": "Lena", "initials": "L"}], "type": "journal article", "published": "2021-12-07", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "12", "pages": "743890", "issn-l": "1664-3224"}, "abstract": "Both anti-viral and anti-inflammatory bronchial effects are warranted to treat viral infections in asthma. We sought to investigate if imiquimod, a TLR7 agonist, exhibits such dual actions in ex vivo cultured human bronchial epithelial cells (HBECs), targets for SARS-CoV-2 infectivity.\n\nTo investigate bronchial epithelial effects of imiquimod of potential importance for anti-viral treatment in asthmatic patients.\n\nEffects of imiquimod alone were examined in HBECs from healthy (N=4) and asthmatic (N=18) donors. Mimicking SARS-CoV-2 infection, HBECs were stimulated with poly(I:C), a dsRNA analogue, or SARS-CoV-2 spike-protein 1 (SP1; receptor binding) with and without imiquimod treatment. Expression of SARS-CoV-2 receptor (ACE2), pro-inflammatory and anti-viral cytokines were analyzed by RT-qPCR, multiplex ELISA, western blot, and Nanostring and proteomic analyses.\n\nImiquimod reduced ACE2 expression at baseline and after poly(I:C) stimulation. Imiquimod also reduced poly(I:C)-induced pro-inflammatory cytokines including IL-1\u03b2, IL-6, IL-8, and IL-33. Furthermore, imiquimod increased IFN-\u03b2 expression, an effect potentiated in presence of poly(I:C) or SP1. Multiplex mRNA analysis verified enrichment in type-I IFN signaling concomitant with suppression of cytokine signaling pathways induced by imiquimod in presence of poly(I:C). Exploratory proteomic analyses revealed potentially protective effects of imiquimod on infections.\n\nImiquimod triggers viral resistance mechanisms in HBECs by decreasing ACE2 and increasing IFN-\u03b2 expression. Additionally, imiquimod improves viral infection tolerance by reducing viral stimulus-induced epithelial cytokines involved in severe COVID-19 infection. Our imiquimod data highlight feasibility of producing pluripotent drugs potentially suited for anti-viral treatment in asthmatic subjects.", "doi": "10.3389/fimmu.2021.743890", "pmid": "34950134", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8688760"}], "notes": [], "created": "2022-01-04T15:28:07.292Z", "modified": "2022-01-04T15:28:07.306Z"}, {"entity": "publication", "iuid": "635c7b339a06434fa64ae02072cf14ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/635c7b339a06434fa64ae02072cf14ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/635c7b339a06434fa64ae02072cf14ef"}}, "title": "An observational study of intermediate or high dose thromboprophylaxis for critically ill COVID-19 patients.", "authors": [{"family": "Jonmarker", "given": "Sandra", "initials": "S", "orcid": "0000-0001-5836-8594", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d28ab27b84f40e2b3d57c91595ece92.json"}}, {"family": "Litorell", "given": "Jacob", "initials": "J"}, {"family": "Dahlberg", "given": "Martin", "initials": "M"}, {"family": "Stackelberg", "given": "Otto", "initials": "O"}, {"family": "Everhov", "given": "\u00c5sa H", "initials": "\u00c5H"}, {"family": "S\u00f6derberg", "given": "M\u00e5rten", "initials": "M"}, {"family": "Rubenson-Wahlin", "given": "Rebecka", "initials": "R"}, {"family": "G\u00fcnther", "given": "Mattias", "initials": "M", "orcid": "0000-0003-2372-6114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9150a7883334344ba7c4abfbe273fef.json"}}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}, {"family": "Hollenberg", "given": "Jacob", "initials": "J"}, {"family": "Joelsson-Alm", "given": "Eva", "initials": "E", "orcid": "0000-0002-9041-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07a091265e654b21bc27fa14b93e4ec0.json"}}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-12-07", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172"}, "abstract": "Critically ill COVID-19 patients have a high reported incidence of thromboembolic complications and the optimal dose of thromboprophylaxis is not yet determined. The aim of this study was to investigate if 90-day mortality differed between patients treated with intermediate or high dose thromboprophylaxis.\n\nIn this retrospective study, all critically ill COVID-19 patients admitted to intensive care from March 6 until July 15, 2020, were eligible. Patients were categorized into groups according to daily dose of thromboprophylaxis. Dosing was based on local standardized recommendations, not on degree of critical illness or risk of thrombosis. Cox proportional hazards regression was used to estimate hazard ratios of death within 90 days from ICU admission. Multivariable models were adjusted for sex, age, body-mass index, Simplified Acute Physiology Score III, invasive respiratory support, glucocorticoids, and dosing strategy of thromboprophylaxis.\n\nA total of 165 patients were included; 92 intermediate and 73 high dose thromboprophylaxis. Baseline characteristics did not differ between groups. The 90-day mortality was 19.6% in patients with intermediate dose and 19.2% in patients with high dose thromboprophylaxis. Multivariable hazard ratio of death within 90 days was 0.74 (95% CI, 0.36-1.53) for the high dose group compared to intermediate dose group. Multivariable hazard ratio for thromboembolic events and bleedings within 28 days were 0.93 (95% CI 0.37-2.29) and 0.84 (95% CI 0.28-2.54) for high versus intermediate dose, respectively.\n\nA difference in 90-day mortality between intermediate and high dose thromboprophylaxis could neither be confirmed nor rejected due to a small sample size.", "doi": "10.1111/aas.14013", "pmid": "34875111", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-12T07:14:59.689Z", "modified": "2021-12-12T07:14:59.804Z"}, {"entity": "publication", "iuid": "ceb2eb041f8846e2909fc611030c9123", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ceb2eb041f8846e2909fc611030c9123.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ceb2eb041f8846e2909fc611030c9123"}}, "title": "1H, 13C and 15N resonance assignment of the SARS-CoV-2 full-length nsp1 protein and its mutants reveals its unique secondary structure features in solution.", "authors": [{"family": "Agback", "given": "Tatiana", "initials": "T"}, {"family": "Dominguez", "given": "Francisco", "initials": "F"}, {"family": "Frolov", "given": "Ilya", "initials": "I"}, {"family": "Frolova", "given": "Elena I", "initials": "EI"}, {"family": "Agback", "given": "Peter", "initials": "P", "orcid": "0000-0003-2226-0746", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/660f06a0871c4d87a362f2a7dbf1dc98.json"}}], "type": "journal article", "published": "2021-12-07", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "12", "pages": "e0251834", "issn-l": "1932-6203"}, "abstract": "Structural characterization of the SARS-CoV-2 full length nsp1 protein will be an essential tool for developing new target-directed antiviral drugs against SARS-CoV-2 and for further understanding of intra- and intermolecular interactions of this protein. As a first step in the NMR studies of the protein, we report the 1H, 13C and 15N resonance backbone assignment as well as the C\u03b2 of the apo form of the full-lengthSARS-CoV-2 nsp1 including the folded domain together with the flaking N- and C- terminal intrinsically disordered fragments. The 19.8 kD protein was characterized by high-resolution NMR. Validation of assignment have been done by using two different mutants, H81P and K129E/D48E as well as by amino acid specific experiments. According to the obtained assignment, the secondary structure of the folded domain in solution was almost identical to its previously published X-ray structure as well as another published secondary structure obtained by NMR, but some discrepancies have been detected. In the solution SARS-CoV-2 nsp1 exhibited disordered, flexible N- and C-termini with different dynamic characteristics. The short peptide in the beginning of the disordered C-terminal domain adopted two different conformations distinguishable on the NMR time scale. We propose that the disordered and folded nsp1 domains are not fully independent units but are rather involved in intramolecular interactions. Studies of the structure and dynamics of the SARS-CoV-2 mutant in solution are on-going and will provide important insights into the molecular mechanisms underlying these interactions.", "doi": "10.1371/journal.pone.0251834", "pmid": "34874953", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-14234"}, {"db": "URL", "key": "https://bmrb.io/data_library/summary/index.php?bmrbId=50915", "description": "https://bmrb.io/data_library/summary/index.php?bmrbId=50915"}], "notes": [], "created": "2021-12-12T07:11:59.861Z", "modified": "2021-12-12T07:14:03.149Z"}, {"entity": "publication", "iuid": "2ebebec3c32942c3bf6b1fd15d1623fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ebebec3c32942c3bf6b1fd15d1623fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ebebec3c32942c3bf6b1fd15d1623fa"}}, "title": "Impact of the COVID-19 pandemic on food production and animal health.", "authors": [{"family": "Rahimi", "given": "Parastoo", "initials": "P"}, {"family": "Islam", "given": "Md Saiful", "initials": "MS"}, {"family": "Duarte", "given": "Phelipe Magalh\u00e3es", "initials": "PM"}, {"family": "Tazerji", "given": "Sina Salajegheh", "initials": "SS"}, {"family": "Sobur", "given": "Md Abdus", "initials": "MA"}, {"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME"}, {"family": "Ashour", "given": "Hossam M", "initials": "HM"}, {"family": "Rahman", "given": "Md Tanvir", "initials": "MT"}], "type": "journal article", "published": "2021-12-06", "journal": {"title": "Trends Food Sci Technol", "issn": "0924-2244", "issn-l": null}, "abstract": "The new coronavirus, named the severe acute respiratory coronavirus syndrome 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 2019 (COVID-19). COVID-19 originated in China and spread to other countries and continents causing a variety of respiratory and non-respiratory symptoms that led to death in severe cases.\n\nIn this review, we discuss and analyze the impact of the COVID-19 pandemic on animal production systems and food products including meat, dairy, eggs, and processed food, in addition to assessing the pandemic's impact on animal health care systems, animal health care quality, animal welfare, food chain sustainability, and the global economy. We also provide effective recommendations to animal producers, veterinary healthcare professionals, workers in animal products industries, and governments to alleviate the effects of the pandemic on livestock farming and production systems.\n\nPort restrictions, border restrictions, curfews, and social distancing limitations led to reduced quality, productivity, and competitiveness of key productive sectors. The restrictions have hit the livestock sector hard by disrupting the animal feed supply chain, reducing animal farming services, limiting animal health services including delays in diagnosis and treatment of diseases, limiting access to markets and consumers, and reducing labor-force participation. The inhumane culling of animals jeopardized animal welfare. Egg smashing, milk dumping, and other animal product disruptions negatively impacted food production, consumption, and access to food originating from animals. In summary, COVID-triggered lockdowns and limitations on local and international trade have taken their toll on food production, animal production, and animal health and welfare. COVID-19 reverberations could exacerbate food insecurity, hunger, and global poverty. The effects could be massive on the most vulnerable populations and the poorest nations.", "doi": "10.1016/j.tifs.2021.12.003", "pmid": "34898853", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0924-2244(21)00660-9"}, {"db": "pmc", "key": "PMC8647343"}], "notes": [], "created": "2021-12-18T18:00:15.493Z", "modified": "2021-12-18T18:00:15.507Z"}, {"entity": "publication", "iuid": "6033244c29174016b12902edef9cdb24", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6033244c29174016b12902edef9cdb24.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6033244c29174016b12902edef9cdb24"}}, "title": "Convalescence plasma treatment of COVID-19: results from a prematurely terminated randomized controlled open-label study in Southern Sweden.", "authors": [{"family": "Holm", "given": "Karin", "initials": "K", "orcid": "0000-0002-8289-5949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7f590df41084ab28d7a1ac80b1b90e7.json"}}, {"family": "Lundgren", "given": "Maria N", "initials": "MN"}, {"family": "Kjeldsen-Kragh", "given": "Jens", "initials": "J"}, {"family": "Ljungquist", "given": "Oskar", "initials": "O"}, {"family": "B\u00f6ttiger", "given": "Blenda", "initials": "B"}, {"family": "Wik\u00e9n", "given": "Christian", "initials": "C"}, {"family": "\u00d6berg", "given": "Jonas", "initials": "J"}, {"family": "Fernstr\u00f6m", "given": "Nils", "initials": "N"}, {"family": "Rosendal", "given": "Ebba", "initials": "E"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "Wigren Bystr\u00f6m", "given": "Julia", "initials": "J"}, {"family": "Forsell", "given": "Mattias", "initials": "M"}, {"family": "Landin-Olsson", "given": "Mona", "initials": "M"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-12-04", "journal": {"title": "BMC Res Notes", "issn": "1756-0500", "volume": "14", "issue": "1", "pages": "440", "issn-l": null}, "abstract": "Convalescent plasma has been tried as therapy for various viral infections. Early observational studies of convalescent plasma treatment for hospitalized COVID-19 patients were promising, but randomized controlled studies were lacking at the time. The objective of this study was to investigate if convalescent plasma is beneficial to hospitalized patients with COVID-19.\n\nHospitalized patients with confirmed COVID-19 and an oxygen saturation below 94% were randomized 1:1 to receive convalescent plasma in addition to standard of care or standard of care only. The primary outcome was number of days of oxygen treatment to keep saturation above 93% within 28 days from inclusion. The study was prematurely terminated when thirty-one of 100 intended patients had been included. The median time of oxygen treatment among survivors was 11 days (IQR 6-15) for the convalescent plasma group and 7 days (IQR 5-9) for the standard of care group (p = 0.4, median difference -4). Two patients in the convalescent plasma group and three patients in the standard of care group died (p = 0.64, OR 0.49, 95% CI 0.08-2.79). Thus no significant differences were observed between the groups. Trial registration ClinicalTrials NCT04600440, retrospectively registered Oct 23, 2020.", "doi": "10.1186/s13104-021-05847-7", "pmid": "34863304", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13104-021-05847-7"}, {"db": "ClinicalTrials.gov", "key": "NCT04600440"}], "notes": [], "created": "2021-12-12T07:18:34.485Z", "modified": "2021-12-12T07:18:34.529Z"}, {"entity": "publication", "iuid": "e1e268c1633f431a94c89397bef8d775", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e1e268c1633f431a94c89397bef8d775.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e1e268c1633f431a94c89397bef8d775"}}, "title": "Longevity of anti-spike and anti-nucleocapsid antibodies after COVID-19 in solid organ transplant recipients compared to immunocompetent controls.", "authors": [{"family": "S\u00f8fteland", "given": "John Mackay", "initials": "JM", "orcid": "0000-0001-7993-5906", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ab059cbe643422e9da67347e1123200.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Liljeqvist", "given": "Jan-\u00c5ke", "initials": "J\u00c5"}, {"family": "Friman", "given": "Vanda", "initials": "V"}, {"family": "de Coursey", "given": "Emily", "initials": "E"}, {"family": "Karason", "given": "Kristjan", "initials": "K"}, {"family": "Ekelund", "given": "Jan", "initials": "J"}, {"family": "Felldin", "given": "Marie", "initials": "M"}, {"family": "Magnusson", "given": "Jesper", "initials": "J", "orcid": "0000-0002-5630-0155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d2adc110fad45618c8dc73505a3358b.json"}}, {"family": "Baid-Agrawal", "given": "Seema", "initials": "S"}, {"family": "Wallquist", "given": "Carin", "initials": "C"}, {"family": "Schult", "given": "Andreas", "initials": "A"}, {"family": "Jacobsson", "given": "Hanna", "initials": "H"}, {"family": "Bergdahl", "given": "Anders", "initials": "A"}, {"family": "Bemark", "given": "Mats", "initials": "M", "orcid": "0000-0001-7416-9819", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ae923943b6c4b4bb74ca1e14b426351.json"}}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Holm Gunnarsson", "given": "Inger", "initials": "I"}, {"family": "Stenstr\u00f6m", "given": "Jan", "initials": "J"}, {"family": "Leach", "given": "Susannah", "initials": "S", "orcid": "0000-0002-9614-2753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18d00be831d241dca238b3253d1b45f6.json"}}], "type": "journal article", "published": "2021-12-03", "journal": {"title": "Am J Transplant", "issn": "1600-6143", "issn-l": null}, "abstract": "Solid organ transplant recipients (SOTRs) are on lifelong immunosuppression, which may interfere with adaptive immunity to COVID-19. The data on dynamics and duration of antibody response in SOTRs are limited. This longitudinal study examined the longevity of both anti-spike (S)- and anti-nucleocapsid (N)-specific IgG-antibodies after COVID-19 in SOTRs compared to matched immunocompetent persons. SOTRs (n=65) were matched with controls (n=65) for COVID-19 disease severity, age, and sex in order of priority. Serum-IgG-antibodies against N- and S-antigens of SARS-CoV-2 were analyzed. At 1 and 9 months after COVID-19, anti-S-IgG detectability decreased from 91% to 82% in SOTRs versus 100% to 95% in controls, whereas the anti-N-IgG decreased from 63% to 29% in SOTRs versus 89% to 46% in controls. A matched paired analysis showed SOTRs having significantly lower levels of anti-N-IgG at all time points (1-month P=0.007, 3-months P<0.001, 6-months P=0.019 and 9-months P=0.021) but not anti-S-IgG at any time points. A mixed-model analysis confirmed these findings except for anti-S-IgG at one month (p=0.005) and identified severity score as the most important predictor of antibody response. SOTRs mount comparable S-specific, but not N-specific, antibody responses to SARS-CoV-2 infection compared to immunocompetent controls.", "doi": "10.1111/ajt.16909", "pmid": "34860447", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-13T06:15:42.289Z", "modified": "2021-12-13T06:16:04.675Z"}, {"entity": "publication", "iuid": "4d61723b79c4473b863d8be10bd85269", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4d61723b79c4473b863d8be10bd85269.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4d61723b79c4473b863d8be10bd85269"}}, "title": "Waning infant pertussis during COVID-19 pandemic.", "authors": [{"family": "Falkenstein-Hagander", "given": "Kathy", "initials": "K", "orcid": "0000-0001-8070-8591", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6bc0ee6ad2a241be887a0261ffcec215.json"}}, {"family": "Appelqvist", "given": "Emma", "initials": "E"}, {"family": "Cavefors", "given": "Ann-Sofie Frisk", "initials": "AF"}, {"family": "K\u00e4llberg", "given": "Henrik", "initials": "H"}, {"family": "Nilsson", "given": "Lennart Jan", "initials": "LJ"}, {"family": "Silfverdal", "given": "Sven-Arne", "initials": "SA", "orcid": "0000-0002-3606-3797", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82e58fba252946a091a386588684f781.json"}}, {"family": "Storsaeter", "given": "Jann", "initials": "J"}, {"family": "Aronsson", "given": "Bernice", "initials": "B"}], "type": "journal article", "published": "2021-12-02", "journal": {"title": "Arch Dis Child", "issn": "1468-2044", "issn-l": null}, "abstract": "Measures to reduce the spread of COVID-19 have been associated with reduction in other respiratory infections. Results of a national Swedish cohort study of infant pertussis during April 2020-September 2021 were compared with those during January 2014-March 2020. The number of pertussis cases decreased significantly during the COVID-19 pandemic, from an average of 21 infant cases per quarter of a year before the pandemic to an average of 1 case per quarter during the pandemic. Swedish strategies to mitigate the spread of COVID-19 seem to have had an impact on pertussis incidence in infants.", "doi": "10.1136/archdischild-2021-323055", "pmid": "34857511", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "archdischild-2021-323055"}], "notes": [], "created": "2021-12-18T18:07:33.933Z", "modified": "2021-12-18T18:07:34.039Z"}, {"entity": "publication", "iuid": "ced65694d052422c83e7f1562e1398ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ced65694d052422c83e7f1562e1398ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ced65694d052422c83e7f1562e1398ca"}}, "title": "Soluble Urokinase Plasminogen Activator Receptor (suPAR) Independently Predicts Severity and Length of Hospitalisation in Patients With COVID-19.", "authors": [{"family": "Enocsson", "given": "Helena", "initials": "H"}, {"family": "Idoff", "given": "Cornelia", "initials": "C"}, {"family": "Gustafsson", "given": "Annette", "initials": "A"}, {"family": "Govender", "given": "Melissa", "initials": "M"}, {"family": "Hopkins", "given": "Francis", "initials": "F"}, {"family": "Larsson", "given": "Marie", "initials": "M"}, {"family": "Nilsdotter-Augustinsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Sj\u00f6wall", "given": "Johanna", "initials": "J"}], "type": "journal article", "published": "2021-12-02", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "8", "pages": "791716", "issn-l": null}, "abstract": "Background: Efficient healthcare based on prognostic variables in hospitalised patients with COVID-19 could reduce the risk of complications and death. Recently, soluble urokinase Plasminogen Activator Receptor (suPAR) was shown to predict respiratory failure, kidney injury, and clinical outcome in patients with SARS-CoV-2 infection. The aim of this study was to investigate the value of suPAR as a prognostic tool, in comparison with other variables, regarding disease severity and length of hospital stay in patients with COVID-19. Patients and Methods: Individuals hospitalised with COVID-19 (40 males, 20 females; median age 57.5 years) with a median symptom duration of 10 days and matched, healthy controls (n = 30) were included. Admission levels of suPAR were measured in serum by enzyme-linked immunosorbent assay. Blood cell counts, C-reactive protein (CRP) levels, lactate dehydrogenase (LDH), plasma creatinine and estimated glomerular filtration rates were analysed and oxygen demand, level of care and length of hospitalisation recorded. Results: Patients had significantly higher suPAR levels compared to controls (P < 0.001). Levels were higher in severely/critically (median 6.6 ng/mL) compared with moderately ill patients (median 5.0 ng/mL; P = 0.002). In addition, suPAR levels correlated with length of hospitalisation (rho = 0.35; P = 0.006). Besides suPAR, LDH, CRP, neutrophil count, neutrophil-to-monocyte and neutrophil-to-lymphocyte ratio, body mass index and chronic renal failure were discriminators of COVID-19 severity and/or predictors of length of hospitalisation. Conclusion: Admission levels of suPAR were higher in patients who developed severe/critical COVID-19 and associated with length of hospital stay. In addition, we showed that suPAR functioned as an independent predictor of COVID-19 disease severity.", "doi": "10.3389/fmed.2021.791716", "pmid": "34926532", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8674575"}], "notes": [], "created": "2022-01-03T15:22:31.284Z", "modified": "2022-01-03T15:22:59.724Z"}, {"entity": "publication", "iuid": "d248640d9017480f810e715041594cc3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d248640d9017480f810e715041594cc3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d248640d9017480f810e715041594cc3"}}, "title": "Randomised clinical trials in critical care: past, present and future.", "authors": [{"family": "Granholm", "given": "Anders", "initials": "A", "orcid": "0000-0001-5799-7655", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d058ecb91d4c482abbee511b044ddf75.json"}}, {"family": "Alhazzani", "given": "Waleed", "initials": "W"}, {"family": "Derde", "given": "Lennie P G", "initials": "LPG"}, {"family": "Angus", "given": "Derek C", "initials": "DC"}, {"family": "Zampieri", "given": "Fernando G", "initials": "FG"}, {"family": "Hammond", "given": "Naomi E", "initials": "NE"}, {"family": "Sweeney", "given": "Rob Mac", "initials": "RM"}, {"family": "Myatra", "given": "Sheila N", "initials": "SN"}, {"family": "Azoulay", "given": "Elie", "initials": "E"}, {"family": "Rowan", "given": "Kathryn", "initials": "K"}, {"family": "Young", "given": "Paul J", "initials": "PJ"}, {"family": "Perner", "given": "Anders", "initials": "A"}, {"family": "M\u00f8ller", "given": "Morten Hylander", "initials": "MH"}], "type": "journal article", "published": "2021-12-02", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "issn-l": "0342-4642"}, "abstract": "Randomised clinical trials (RCTs) are the gold standard for providing unbiased evidence of intervention effects. Here, we provide an overview of the history of RCTs and discuss the major challenges and limitations of current critical care RCTs, including overly optimistic effect sizes; unnuanced conclusions based on dichotomization of results; limited focus on patient-centred outcomes other than mortality; lack of flexibility and ability to adapt, increasing the risk of inconclusive results and limiting knowledge gains before trial completion; and inefficiency due to lack of re-use of trial infrastructure. We discuss recent developments in critical care RCTs and novel methods that may provide solutions to some of these challenges, including a research programme approach (consecutive, complementary studies of multiple types rather than individual, independent studies), and novel design and analysis methods. These include standardization of trial protocols; alternative outcome choices and use of core outcome sets; increased acceptance of uncertainty, probabilistic interpretations and use of Bayesian statistics; novel approaches to assessing heterogeneity of treatment effects; adaptation and platform trials; and increased integration between clinical trials and clinical practice. We outline the advantages and discuss the potential methodological and practical disadvantages with these approaches. With this review, we aim to inform clinicians and researchers about conventional and novel RCTs, including the rationale for choosing one or the other methodological approach based on a thorough discussion of pros and cons. Importantly, the most central feature remains the randomisation, which provides unparalleled restriction of confounding compared to non-randomised designs by reducing confounding to chance.", "doi": "10.1007/s00134-021-06587-9", "pmid": "34853905", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-021-06587-9"}, {"db": "pmc", "key": "PMC8636283"}], "notes": [], "created": "2021-12-18T18:08:36.279Z", "modified": "2021-12-18T18:08:36.311Z"}, {"entity": "publication", "iuid": "4b5d4b1020ba4be3b34456be993e921a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b5d4b1020ba4be3b34456be993e921a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b5d4b1020ba4be3b34456be993e921a"}}, "title": "Lifestyle and mental health 1 year into COVID-19.", "authors": [{"family": "Barbieri", "given": "Paolo Nicola", "initials": "PN"}, {"family": "Giuntella", "given": "Osea", "initials": "O"}, {"family": "Saccardo", "given": "Silvia", "initials": "S"}, {"family": "Sadoff", "given": "Sally", "initials": "S"}], "type": "journal article", "published": "2021-12-02", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "23349", "issn-l": "2045-2322"}, "abstract": "In previous work, Giuntella et al. (Proc Natl Acad Sci 118:e2016632118, 2021), we documented large disruptions to physical activity, sleep, time use and mental health among young adults at the onset of the COVID-19 pandemic in Spring 2020. This study explores the trends 1 year into COVID-19, as vaccines began to roll out, COVID-19 deaths declined, and social distancing measures eased in the United States. We combine biometric and survey data from multiple cohorts of college students spanning Spring 2019 through Spring 2021 (N = 1179). Our results show persistent impacts of the pandemic on physical activity and mental health. One year into the pandemic, daily steps averaged about 6300 per day compared to about 9800 per day prior to the pandemic, a 35% decline. Almost half of participants were at risk of clinical depression compared to a little over one-third prior to the pandemic, a 36% increase. The impacts on screen time, social interactions and sleep duration at the onset of COVID-19 largely dissipated over the course of the pandemic, though screen time remained significantly higher than pre-pandemic levels. In contrast to the sharp changes in lifestyle and mental health documented as the pandemic emerged in March 2020, we do not find evidence of behavioral changes or improvements in mental well-being over the course of Spring 2021 as the pandemic eased.", "doi": "10.1038/s41598-021-02702-4", "pmid": "34857806", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-02702-4"}, {"db": "pmc", "key": "PMC8640003"}], "notes": [], "created": "2021-12-18T18:07:18.938Z", "modified": "2021-12-18T18:07:18.950Z"}, {"entity": "publication", "iuid": "6bda32f2b9534efea4411fa34bd79b94", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6bda32f2b9534efea4411fa34bd79b94.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6bda32f2b9534efea4411fa34bd79b94"}}, "title": "Secondary effects of the COVID-19 pandemic on surgical management of hepatopancreatobiliary malignancies in the Nordic capitals.", "authors": [{"family": "Holmberg", "given": "Marcus", "initials": "M", "orcid": "0000-0002-7217-4240", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76b4c749d77a400d83c23c415c1162de.json"}}, {"family": "Koppatz", "given": "Hanna", "initials": "H"}, {"family": "Jansson", "given": "Anders", "initials": "A"}, {"family": "Hillings\u00f8", "given": "Jens Georg", "initials": "JG", "orcid": "0000-0002-2381-7836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb166927097b40fe82cacd2d2f4793bf.json"}}, {"family": "Noergaard Larsen", "given": "Peter", "initials": "P"}, {"family": "Lassen", "given": "Kristoffer", "initials": "K", "orcid": "0000-0003-0039-6554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/401fe4d0146a494db0e6cf59b7be9d54.json"}}, {"family": "Sallinen", "given": "Ville", "initials": "V", "orcid": "0000-0001-5394-4169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/85f283d1d6554ad5a8475ceb27e195bc.json"}}, {"family": "Yaqub", "given": "Sheraz", "initials": "S", "orcid": "0000-0002-5696-2319", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4327b96c3bc4b9fbe30dd894b62c559.json"}}, {"family": "Sparrelid", "given": "Ernesto", "initials": "E"}], "type": "journal article", "published": "2021-12-01", "journal": {"title": "Br J Surg", "issn": "1365-2168", "issn-l": null}, "abstract": null, "doi": "10.1093/bjs/znab405", "pmid": "34850850", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6447105"}], "notes": [], "created": "2021-12-18T18:09:38.851Z", "modified": "2021-12-18T18:09:39.053Z"}, {"entity": "publication", "iuid": "cfb3f01277ce402fbb487d4eb3edf6f5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfb3f01277ce402fbb487d4eb3edf6f5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfb3f01277ce402fbb487d4eb3edf6f5"}}, "title": "Rituximab Infusion Timing, Cumulative Dose, and Hospitalization for COVID-19 in Persons With Multiple Sclerosis in Sweden.", "authors": [{"family": "McKay", "given": "Kyla A", "initials": "KA"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Englund", "given": "Simon", "initials": "S"}, {"family": "He", "given": "Anna", "initials": "A"}, {"family": "Langer-Gould", "given": "Annette", "initials": "A"}, {"family": "Hillert", "given": "Jan", "initials": "J"}, {"family": "Frisell", "given": "Thomas", "initials": "T"}], "type": "clinical trial", "published": "2021-12-01", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "volume": "4", "issue": "12", "pages": "e2136697", "issn-l": null}, "abstract": null, "doi": "10.1001/jamanetworkopen.2021.36697", "pmid": "34851401", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "2786701"}, {"db": "pmc", "key": "PMC8637249"}], "notes": [], "created": "2021-12-18T18:09:05.760Z", "modified": "2021-12-18T18:09:05.773Z"}, {"entity": "publication", "iuid": "249f16ed4f2846019d1404d1d2f0c6f5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/249f16ed4f2846019d1404d1d2f0c6f5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/249f16ed4f2846019d1404d1d2f0c6f5"}}, "title": "Occupational exposure and risk of transmission of SARS-CoV2 among European anaesthetists.", "authors": [{"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Longrois", "given": "Dan", "initials": "D"}, {"family": "Bruder", "given": "Nicolas", "initials": "N"}], "type": "journal article", "published": "2021-12-01", "journal": {"title": "Eur J Anaesthesiol", "issn": "1365-2346", "volume": "38", "issue": "12", "pages": "1272-1273", "issn-l": null}, "abstract": null, "doi": "10.1097/EJA.0000000000001607", "pmid": "34735396", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "00003643-202112000-00008"}], "notes": [], "created": "2021-11-26T15:40:44.860Z", "modified": "2021-11-26T15:40:44.874Z"}, {"entity": "publication", "iuid": "1022991309d94307b1cdce7fed18bade", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1022991309d94307b1cdce7fed18bade.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1022991309d94307b1cdce7fed18bade"}}, "title": "Impact of the COVID-19 Pandemic on the General Mental Health in Sweden: No Observed Changes in the Dispensed Amount of Common Psychotropic Medications in the Region of Scania.", "authors": [{"family": "Wolfschlag", "given": "Mirjam", "initials": "M"}, {"family": "Grudet", "given": "C\u00e9cile", "initials": "C"}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-12-01", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "731297", "issn-l": "1664-0640"}, "abstract": "Some first investigations have focused on the consequences of the COVID-19 pandemic for the general mental health after its outbreak in 2020. According to multiple self-reporting surveys, symptoms of stress, anxiety, and depression have risen worldwide. Even some studies based on health care records start to be published, providing more objective and statistically reliable results. Additionally, concerns have been raised, to what extend the access to mental health care has been compromised by the COVID-19 outbreak. The aim of this study was to detect changes in prescription trends of common psychotropic medications in the Swedish region of Scania. The monthly dispensed amounts of selected pharmaceuticals were compared from January 2018 until January 2021, regarding the prescription trends before and after the outbreak of COVID-19. Using an interrupted time series analysis for each medication, no general trend changes were observed. On the one hand, a possible deterioration of the general mental health could not be confirmed by these results. On the other hand, the access to mental health care did not seem to be impaired by the pandemic. When interpreting findings related to the COVID-19 pandemic, regional differences and country-specific approaches for coping with the pandemic should be considered. The Swedish population, for instance, never experienced a full \"lock-down\" and within Sweden the time point of the outbreak waves differed regionally. In general, the effects of the COVID-19 outbreak on mental health are still unclear and need to be investigated further in an international comparison.", "doi": "10.3389/fpsyt.2021.731297", "pmid": "34925084", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8671297"}], "notes": [], "created": "2022-01-03T15:22:11.541Z", "modified": "2022-01-03T15:22:11.553Z"}, {"entity": "publication", "iuid": "975ae46bee0a4573a8a3cb07c24dbab1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/975ae46bee0a4573a8a3cb07c24dbab1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/975ae46bee0a4573a8a3cb07c24dbab1"}}, "title": "Immunogenicity and tolerability of COVID-19 vaccination in peritoneal dialysis patients-A prospective observational cohort study.", "authors": [{"family": "Haase", "given": "Michael", "initials": "M", "orcid": "0000-0001-8212-7416", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3d5795641ee4ff0ab46f79603ba5e73.json"}}, {"family": "Lesny", "given": "Paul", "initials": "P"}, {"family": "Haase-Fielitz", "given": "Anja", "initials": "A"}, {"family": "Anderson", "given": "Mark", "initials": "M"}, {"family": "Cloherty", "given": "Gavin", "initials": "G"}, {"family": "Stec", "given": "Michael", "initials": "M"}, {"family": "Lucas", "given": "Carlos", "initials": "C"}, {"family": "Santos-Araujo", "given": "Carla", "initials": "C"}, {"family": "Haarhaus", "given": "Mathias", "initials": "M"}, {"family": "Macario", "given": "Fernando", "initials": "F"}], "type": "journal article", "published": "2021-12-01", "journal": {"title": "Semin Dial", "issn": "1525-139X", "issn-l": null}, "abstract": "In peritoneal dialysis (PD) patients, information on the immunogenicity and tolerability of SARS-CoV-2 vaccination is still scarce. We compared the immunogenicity and tolerability of SARS-CoV-2 vaccination of PD patients with that of medical personnel.\n\nIn a prospective observational cohort study, PD patients and immunocompetent medical personnel were evaluated for SARS-CoV-2 spike-IgG- and Nucleocapsid-IgG-antibody-levels before, 2 weeks after the first, and 6 weeks after the second SARS-CoV-2 vaccination and vaccine tolerability after the first and second vaccination.\n\nIn COVID-19-na\u00efve PD patients (N = 19), lower SARS-CoV-2-spike-IgG-levels were found compared with COVID-19-na\u00efve medical personnel (N = 24) 6 weeks after second vaccination (median 1438 AU/ml [25th-75th percentile 775-5261] versus 4577 [1529-9871]; p = 0.045). This finding resulted in a lower rate of strong vaccine response (spike-IgG \u2265 1000 AU/ml) of COVID-19-na\u00efve PD patients compared with medical personnel (58% versus 92%; p = 0.013), but not for seroconversion rate (spike-IgG \u2265 50 AU/ml: 100% vs. 100%; p > 0.99). After first vaccination, COVID-na\u00efve PD patients presented with significantly fewer side effects than medical personnel (number of any side effect: 1 [1-2] vs. 4 [1-7]; p = 0.015). A similar pattern with slightly decreased frequencies of side effects was observed for tolerability of second SARS-CoV-2 vaccination in PD patients and medical personnel (number of any side effects: 1 [1-1] vs. 2 [1-5]; p = 0.006).\n\nSARS-CoV-2 vaccination in COVID-19-na\u00efve PD patients appeared to induce a very high rate of seroconversion but a substantially lower rate of patients with a strong response compared with medical personnel. Vaccination appeared to be safe in the PD patients studied.", "doi": "10.1111/sdi.13043", "pmid": "34854131", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T18:08:07.445Z", "modified": "2021-12-18T18:08:07.524Z"}, {"entity": "publication", "iuid": "a1d55643d2544ade95def5ade92d4e63", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a1d55643d2544ade95def5ade92d4e63.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a1d55643d2544ade95def5ade92d4e63"}}, "title": "First comparison of conventional activated sludge versus root-zone treatment for SARS-CoV-2 RNA removal from wastewaters: Statistical and temporal significance.", "authors": [{"family": "Kumar", "given": "Manish", "initials": "M"}, {"family": "Kuroda", "given": "Keisuke", "initials": "K"}, {"family": "Joshi", "given": "Madhvi", "initials": "M"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Barcelo", "given": "Damia", "initials": "D"}], "type": "journal article", "published": "2021-12-01", "journal": {"title": "Chem Eng J", "issn": "1385-8947", "volume": "425", "pages": "130635", "issn-l": null}, "abstract": "In the initial pandemic phase, effluents from wastewater treatment facilities were reported mostly free from Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) RNA, and thus conventional wastewater treatments were generally considered effective. However, there is a lack of first-hand data on i) comparative efficacy of various treatment processes for SARS-CoV-2 RNA removal; and ii) temporal variations in the removal efficacy of a given treatment process in the backdrop of active COVID-19 cases. This work provides a comparative account of the removal efficacy of conventional activated sludge (CAS) and root zone treatments (RZT) based on weekly wastewater surveillance data, consisting of forty-four samples, during a two-month period. The average genome concentration was higher in the inlets of CAS-based wastewater treatment plant (WWTP) in the Sargasan ward (1.25 \u00d7 103 copies/ L), than that of RZT-based WWTP (7.07 \u00d7 102 copies/ L) in an academic institution campus of Gandhinagar, Gujarat, India. ORF 1ab and S genes appeared to be more sensitive to treatment i.e., significantly reduced (p < 0.05) than N genes (p > 0.05). CAS treatment exhibited better RNA removal efficacy (p = 0.014) than RZT (p = 0.032). Multivariate analyses suggested that the effective genome concentration should be calculated based on the presence/absence of multiple genes. The present study stresses that treated effluents are not always free from SARS-CoV-2 RNA, and the removal efficacy of a given WWTP is prone to exhibit temporal variability owing to variations in active COVID-19 cases in the vicinity and genetic material accumulation over the time. Disinfection seems less effective than the adsorption and coagulation processes for SARS-CoV-2 removal. Results stress the need for further research on mechanistic insight on SARS-CoV-2 removal through various treatment processes taking solid-liquid partitioning into account.", "doi": "10.1016/j.cej.2021.130635", "pmid": "34149304", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S1385-8947(21)02221-X"}, {"db": "pmc", "key": "PMC8200644"}], "notes": [], "created": "2021-06-28T18:24:38.522Z", "modified": "2021-06-28T18:25:01.598Z"}, {"entity": "publication", "iuid": "43d35f6703f84ec795db14f09a692c1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/43d35f6703f84ec795db14f09a692c1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/43d35f6703f84ec795db14f09a692c1d"}}, "title": "Emergence of new SARS-CoV-2 Variant of Concern Omicron (B.1.1.529) - highlights Africa's research capabilities, but exposes major knowledge gaps, inequities of vaccine distribution, inadequacies in global COVID-19 response and control efforts.", "authors": [{"family": "Petersen", "given": "Eskild", "initials": "E"}, {"family": "Ntoumi", "given": "Francine", "initials": "F"}, {"family": "Hui", "given": "David S", "initials": "DS"}, {"family": "Abubakar", "given": "Aisha", "initials": "A"}, {"family": "Kramer", "given": "Laura D", "initials": "LD"}, {"family": "Obiero", "given": "Christina", "initials": "C"}, {"family": "Tambyah", "given": "Paul Anantharajah", "initials": "PA"}, {"family": "Blumberg", "given": "Lucille", "initials": "L"}, {"family": "Yapi", "given": "Richard", "initials": "R"}, {"family": "Al-Abri", "given": "Seif", "initials": "S"}, {"family": "Pinto", "given": "Tatiana de Castro Abreu", "initials": "TCA"}, {"family": "Yeboah-Manu", "given": "Dorothy", "initials": "D"}, {"family": "Haider", "given": "Najmul", "initials": "N"}, {"family": "Asogun", "given": "Danny", "initials": "D"}, {"family": "Velavan", "given": "Thirumalaisamy P", "initials": "TP"}, {"family": "Kapata", "given": "Nathan", "initials": "N"}, {"family": "Bates", "given": "Matthew", "initials": "M"}, {"family": "Ansumana", "given": "Rashid", "initials": "R"}, {"family": "Montaldo", "given": "Chiara", "initials": "C"}, {"family": "Mucheleng'anga", "given": "Luchenga", "initials": "L"}, {"family": "Tembo", "given": "John", "initials": "J"}, {"family": "Mwaba", "given": "Peter", "initials": "P"}, {"family": "Himwaze", "given": "Cordelia M", "initials": "CM"}, {"family": "Hamid", "given": "Muzamil Mahdi Abdel", "initials": "MMA"}, {"family": "Mfinanga", "given": "Sayoki", "initials": "S"}, {"family": "Mboera", "given": "Leonard", "initials": "L"}, {"family": "Raj", "given": "Tajudeen", "initials": "T"}, {"family": "Aklillu", "given": "Eleni", "initials": "E"}, {"family": "Veas", "given": "Francisco", "initials": "F"}, {"family": "Edwards", "given": "Sarah", "initials": "S"}, {"family": "Kaleebu", "given": "Pontiano", "initials": "P"}, {"family": "McHugh", "given": "Timothy D", "initials": "TD"}, {"family": "Chakaya", "given": "Jeremiah", "initials": "J"}, {"family": "Nyirenda", "given": "Thomas", "initials": "T"}, {"family": "Bockarie", "given": "Moses", "initials": "M"}, {"family": "Nyasulu", "given": "Peter S", "initials": "PS"}, {"family": "Wejse", "given": "Christian", "initials": "C"}, {"family": "Muyembe-Tamfum", "given": "Jean-Jacques", "initials": "JJ"}, {"family": "Azhar", "given": "Esam I", "initials": "EI"}, {"family": "Maeurer", "given": "Markus", "initials": "M"}, {"family": "Nachega", "given": "Jean B", "initials": "JB"}, {"family": "Kock", "given": "Richard", "initials": "R"}, {"family": "Ippolito", "given": "Giuseppe", "initials": "G"}, {"family": "Zumla", "given": "Alimuddin", "initials": "A"}], "type": "editorial", "published": "2021-12-01", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712"}, "abstract": null, "doi": "10.1016/j.ijid.2021.11.040", "pmid": "34863925", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)00888-2"}], "notes": [], "created": "2021-12-12T07:17:49.046Z", "modified": "2021-12-12T07:17:49.060Z"}, {"entity": "publication", "iuid": "d8a5430224524a14a61f7f510d8ee762", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d8a5430224524a14a61f7f510d8ee762.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d8a5430224524a14a61f7f510d8ee762"}}, "title": "Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality", "authors": [{"family": "Nakanishi", "given": "Tomoko", "initials": "T", "orcid": "0000-0001-9510-5646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd273e50091d44c3b3e8d1473ce89b0a.json"}}, {"family": "Pigazzini", "given": "Sara", "initials": "S", "orcid": "0000-0002-0641-9393", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b0633eaa95524db89712be8570a96731.json"}}, {"family": "Degenhardt", "given": "Frauke", "initials": "F", "orcid": "0000-0001-7516-3179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab8dc6a0eb504f41a89c140d68b87b6a.json"}}, {"family": "Cordioli", "given": "Mattia", "initials": "M", "orcid": "0000-0002-4872-0520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/973dc15953ef42ddb7844615904f887d.json"}}, {"family": "Butler-Laporte", "given": "Guillaume", "initials": "G", "orcid": "0000-0001-5388-0396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/529dc69151d3463e8480b975d70fa759.json"}}, {"family": "Maya-Miles", "given": "Douglas", "initials": "D", "orcid": "0000-0002-0669-6526", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1ef23ddbaa8475192c07bd33bcbf435.json"}}, {"family": "Bujanda", "given": "Luis", "initials": "L", "orcid": "0000-0002-4353-9968", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de96cde07e1d49d2a2001537b317111a.json"}}, {"family": "Bouysran", "given": "Youssef", "initials": "Y"}, {"family": "Niemi", "given": "Mari E K", "initials": "MEK", "orcid": "0000-0003-0696-6175", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87d6c30c910c4c989095e2f026194490.json"}}, {"family": "Palom", "given": "Adriana", "initials": "A", "orcid": "0000-0002-0130-1302", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a89c9483db484981ad3f218056b35c9a.json"}}, {"family": "Ellinghaus", "given": "David", "initials": "D", "orcid": "0000-0002-4332-6110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a6cdcc3819e45a08ab598ae7afbfb94.json"}}, {"family": "Khan", "given": "Atlas", "initials": "A"}, {"family": "Mart\u00ednez-Bueno", "given": "Manuel", "initials": "M"}, {"family": "Rolker", "given": "Selina", "initials": "S"}, {"family": "Amitrano", "given": "Sara", "initials": "S"}, {"family": "Roade Tato", "given": "Luisa", "initials": "L"}, {"family": "Fava", "given": "Francesca", "initials": "F"}, {"family": "Spinner", "given": "Christoph D", "initials": "CD", "orcid": "0000-0002-3875-5367", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c506eb763b34155bbc6187f4ccb5f62.json"}}, {"family": "Prati", "given": "Daniele", "initials": "D", "orcid": "0000-0002-2281-7498", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/050d5b4534914e2cb3c9ec64bc5fedaa.json"}}, {"family": "Bernardo", "given": "David", "initials": "D", "orcid": "0000-0002-2843-6696", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5cdb7b8db1f4cb18eda0884c430704f.json"}}, {"family": "Garcia", "given": "Federico", "initials": "F"}, {"family": "Darcis", "given": "Gilles", "initials": "G"}, {"family": "Fern\u00e1ndez-Cadenas", "given": "Israel", "initials": "I"}, {"family": "Holter", "given": "Jan Cato", "initials": "JC", "orcid": "0000-0003-1618-5022", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7b6512c252a422badaaa120ee2aa700.json"}}, {"family": "Banales", "given": "Jesus M", "initials": "JM"}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Kiryluk", "given": "Krzysztof", "initials": "K", "orcid": "0000-0002-5047-6715", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d1362394dec4a7e934fd6c79ad94df3.json"}}, {"family": "Duga", "given": "Stefano", "initials": "S", "orcid": "0000-0003-3457-1410", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f14e5b5dec36415fa1627265d55f8754.json"}}, {"family": "Asselta", "given": "Rosanna", "initials": "R"}, {"family": "Pereira", "given": "Alexandre C", "initials": "AC", "orcid": "0000-0002-7782-5540", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bb55d803b824076b67a01d2790d2986.json"}}, {"family": "Romero-G\u00f3mez", "given": "Manuel", "initials": "M", "orcid": "0000-0001-8494-8947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64e5a4afafa14d5eaeb7957c0061622a.json"}}, {"family": "Nafr\u00eda-Jim\u00e9nez", "given": "Beatriz", "initials": "B", "orcid": "0000-0002-4698-5680", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/782c0cfe62d94457a45fa94098bf3aab.json"}}, {"family": "Hov", "given": "Johannes R", "initials": "JR", "orcid": "0000-0002-5900-8096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83964c456ae5424f8138304aa9dbc26b.json"}}, {"family": "Migeotte", "given": "Isabelle", "initials": "I"}, {"family": "Renieri", "given": "Alessandra", "initials": "A"}, {"family": "Planas", "given": "Anna M", "initials": "AM", "orcid": "0000-0002-6147-1880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ecaec25d7eeb43bca29edd1ed56cecc7.json"}}, {"family": "Ludwig", "given": "Kerstin U", "initials": "KU", "orcid": "0000-0002-8541-2519", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02922a1f71c64a8e9dc6aa1c29a20270.json"}}, {"family": "Buti", "given": "Maria", "initials": "M", "orcid": "0000-0002-0732-3078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4207dfbc876c49a58e210b056d3b0191.json"}}, {"family": "Rahmouni", "given": "Souad", "initials": "S", "orcid": "0000-0003-0956-0242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4dac12a55b94325b711fd13394a4285.json"}}, {"family": "Alarc\u00f3n-Riquelme", "given": "Marta E", "initials": "ME", "orcid": "0000-0002-7632-4154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f74dd701d8442c992fe172be2d2c5bf.json"}}, {"family": "Schulte", "given": "Eva C", "initials": "EC", "orcid": "0000-0003-3105-5672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b02ec0962cdc4e15853c4a3aeba4992d.json"}}, {"family": "Franke", "given": "Andre", "initials": "A"}, {"family": "Karlsen", "given": "Tom H", "initials": "TH"}, {"family": "Valenti", "given": "Luca", "initials": "L", "orcid": "0000-0001-8909-0345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/964a9d9544f64f2080930bcaec06d1cf.json"}}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ee1510080704cf6a2a6972deb94123f.json"}}, {"family": "Richards", "given": "J Brent", "initials": "JB", "orcid": "0000-0002-3746-9086", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8994152547ee4765b1653b834c52a21a.json"}}, {"family": "Ganna", "given": "Andrea", "initials": "A"}], "type": "journal-article", "published": "2021-12-01", "journal": {"title": "J Clin Invest", "issn": "1558-8238", "issn-l": null, "volume": "131", "issue": "23", "pages": null}, "abstract": "Abstract\r\nBackground There is considerable variability in COVID-19 outcomes amongst younger adults\u2014and some of this variation may be due to genetic predisposition. We characterized the clinical implications of the major genetic risk factor for COVID-19 severity, and its age-dependent effect, using individual-level data in a large international multi-centre consortium.\r\n\r\nMethod The major common COVID-19 genetic risk factor is a chromosome 3 locus, tagged by the marker rs10490770. We combined individual level data for 13,424 COVID-19 positive patients (N=6,689 hospitalized) from 17 cohorts in nine countries to assess the association of this genetic marker with mortality, COVID-19-related complications and laboratory values. We next examined if the magnitude of these associations varied by age and were independent from known clinical COVID-19 risk factors.\r\n\r\nFindings We found that rs10490770 risk allele carriers experienced an increased risk of all-cause mortality (hazard ratio [HR] 1\u00b74, 95% confidence interval [CI] 1\u00b72\u20131\u00b76) and COVID-19 related mortality (HR 1\u00b75, 95%CI 1\u00b73\u20131\u00b78). Risk allele carriers had increased odds of several COVID-19 complications: severe respiratory failure (odds ratio [OR] 2\u00b70, 95%CI 1\u00b76-2\u00b76), venous thromboembolism (OR 1\u00b77, 95%CI 1\u00b72-2\u00b74), and hepatic injury (OR 1\u00b76, 95%CI 1\u00b72-2\u00b70). Risk allele carriers \u2264 60 years had higher odds of death or severe respiratory failure (OR 2\u00b76, 95%CI 1\u00b78-3\u00b79) compared to those > 60 years OR 1\u00b75 (95%CI 1\u00b73-1\u00b79, interaction p-value=0\u00b704). Amongst individuals \u2264 60 years who died or experienced severe respiratory COVID-19 outcome, we found that 31\u00b78% (95%CI 27\u00b76-36\u00b72) were risk variant carriers, compared to 13\u00b79% (95%CI 12\u00b76-15\u00b72%) of those not experiencing these outcomes. Prediction of death or severe respiratory failure among those \u2264 60 years improved when including the risk allele (AUC 0\u00b782 vs 0\u00b784, p=0\u00b7016) and the prediction ability of rs10490770 risk allele was similar to, or better than, most established clinical risk factors.\r\n\r\nInterpretation The major common COVID-19 risk locus on chromosome 3 is associated with increased risks of morbidity and mortality\u2014and these are more pronounced amongst individuals \u2264 60 years. The effect on COVID-19 severity was similar to, or larger than most established risk factors, suggesting potential implications for clinical risk management.", "doi": "10.1172/jci152386", "pmid": "34597274", "labels": {"Category: Genomics & transcriptomics": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: VR": null, "Type: Journal article": null}, "xrefs": [{"db": "URL", "key": "https://www.medrxiv.org/node/316122.external-links.html", "description": "Procedures for accessing data can be found here (data cannot be publicly shared)"}], "notes": [], "created": "2021-03-15T17:30:18.883Z", "modified": "2022-02-14T16:22:27.472Z"}, {"entity": "publication", "iuid": "900640627af44768b241c6508c8be114", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/900640627af44768b241c6508c8be114.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/900640627af44768b241c6508c8be114"}}, "title": "ACE2 Peptide Fragment Interaction with Different S1 Protein Sites.", "authors": [{"family": "Kuznetsov", "given": "Aleksei", "initials": "A"}, {"family": "Arukuusk", "given": "Piret", "initials": "P"}, {"family": "H\u00e4rk", "given": "Heleri", "initials": "H"}, {"family": "Juronen", "given": "Erkki", "initials": "E"}, {"family": "Ustav", "given": "Mart", "initials": "M"}, {"family": "Langel", "given": "\u00dclo", "initials": "\u00dc"}, {"family": "J\u00e4rv", "given": "Jaak", "initials": "J", "orcid": "0000-0003-1042-2701", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/420b8713e79744df8f4f8c4b83c120d1.json"}}], "type": "journal article", "published": "2021-12-01", "journal": {"title": "Int J Pept Res Ther", "issn": "1573-3149", "volume": "28", "issue": "1", "pages": "7", "issn-l": null}, "abstract": "We study the effect of the peptide QAKTFLDKFNHEAEDLFYQ on the kinetics of the SARS-CoV-2 spike protein S1 binding to angiotensin-converting enzyme 2 (ACE2), with the aim to characterize the interaction mechanism of the SARS-CoV2 virus with its host cell. This peptide corresponds to the sequence 24-42 of the ACE2 \u03b11 domain, which marks the binding site for the S1 protein. The kinetics of S1-ACE2 complex formation was measured in the presence of various concentrations of the peptide using bio-layer interferometry. Formation of the S1-ACE2 complex was inhibited by the peptide in cases where it was preincubated with S1 protein before the binding experiment. The kinetic analysis of S1-ACE2 complex dissociation revealed that preincubation stabilized this complex, and this effect was dependent on the peptide concentration as well as the preincubation time. The results point to the formation of the ternary complex of S1 with ACE2 and the peptide. This is possible in the presence of another binding site for the S1 protein beside the receptor-binding domain for ACE2, which binds the peptide QAKTFLDKFNHEAEDLFYQ. Therefore, we conducted computational mapping of the S1 protein surface, revealing two additional binding sites located at some distance from the main receptor-binding domain on S1. We suggest the possibility to predict and test the short protein derived peptides for development of novel strategies in inhibiting virus infections.\n\nThe online version contains supplementary material available at 10.1007/s10989-021-10324-7.", "doi": "10.1007/s10989-021-10324-7", "pmid": "34867130", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10324"}, {"db": "pmc", "key": "PMC8634746"}], "notes": [], "created": "2021-12-12T07:06:25.059Z", "modified": "2021-12-12T07:06:25.142Z"}, {"entity": "publication", "iuid": "1837bfc6926f48cfa24e4dedbed1098a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1837bfc6926f48cfa24e4dedbed1098a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1837bfc6926f48cfa24e4dedbed1098a"}}, "title": "To be or not to be vaccinated against COVID-19 - The adolescents' perspective - A mixed-methods study in Sweden.", "authors": [{"family": "Nilsson", "given": "S", "initials": "S"}, {"family": "Mattson", "given": "J", "initials": "J"}, {"family": "Berghammer", "given": "M", "initials": "M"}, {"family": "Brorsson", "given": "A-L", "initials": "AL"}, {"family": "Forsner", "given": "M", "initials": "M"}, {"family": "Jenholt Nolbris", "given": "M", "initials": "M"}, {"family": "Kull", "given": "I", "initials": "I"}, {"family": "Lindholm Olinder", "given": "A", "initials": "A"}, {"family": "Ragnarsson", "given": "S", "initials": "S"}, {"family": "Rullander", "given": "A-C", "initials": "AC"}, {"family": "Rydstr\u00f6m", "given": "L-L", "initials": "LL"}, {"family": "Andr\u00e9ia Garcia de Avila", "given": "M", "initials": "M"}, {"family": "Olaya-Contreras", "given": "P", "initials": "P"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Vaccine X", "issn": "2590-1362", "issn-l": null, "volume": "9", "issue": null, "pages": "100117"}, "abstract": "Vaccination of the population seems to be an important strategy in halting the COVID-19 pandemic in both local and global society. The aim of this study was to explore Swedish adolescents' willingness to be vaccinated against COVID-19 and its association with sociodemographic and other possible factors. A survey was distributed in Sweden between 7 July and 8 November 2020. The main qualitative question concerned adolescents' thoughts on vaccination against COVID-19 and evaluated whether the adolescents would like to be vaccinated when a COVID-19 vaccine is made available. In total, 702 adolescents aged between 15 and 19 responded to the questionnaire. A convergent parallel mixed-methods design was used. The results showed that nearly one in three adolescents had not decided if they wanted to get a COVID-19 vaccine, i.e. 30.5%: n = 214. Of the participants 54.3% (n = 381) were willing to be vaccinated. Girls had higher levels of anxiety about the vaccine compared to boys. In addition, high levels of anxiety impacted on the participants' willingness to be vaccinated. One reason for being undecided about the vaccine was that participants felt they did not know enough about it. Practising social distancing increased willingness to be vaccinated, as reflected in the qualitative results which showed participants wanted to be vaccinated to protect others. The results impart important knowledge to healthcare professionals and contribute to their communication with adolescents about vaccine hesitancy.", "doi": "10.1016/j.jvacx.2021.100117", "pmid": "34693273", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S2590-1362(21)00034-6"}, {"db": "pmc", "key": "PMC8524812"}], "notes": [], "created": "2021-10-26T18:23:43.089Z", "modified": "2021-11-29T06:17:03.926Z"}, {"entity": "publication", "iuid": "a50334cf1c724ceaa95e3cc107ba0693", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a50334cf1c724ceaa95e3cc107ba0693.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a50334cf1c724ceaa95e3cc107ba0693"}}, "title": "The Unyvero Hospital-Acquired pneumonia panel for diagnosis of secondary bacterial pneumonia in COVID-19 patients.", "authors": [{"family": "Tellapragada", "given": "Chaitanya", "initials": "C"}, {"family": "Giske", "given": "Christian G", "initials": "CG"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Eur J Clin Microbiol Infect Dis", "issn": "1435-4373", "volume": "40", "issue": "12", "pages": "2479-2485", "issn-l": null}, "abstract": "The study was undertaken to evaluate the performance of Unyvero Hospitalized Pneumonia (HPN) panel application, a multiplex PCR-based method for the detection of bacterial pathogens from lower respiratory tract (LRT) samples, obtained from COVID-19 patients with suspected secondary hospital-acquired pneumonia. Residual LRT samples obtained from critically ill COVID-19 patients with predetermined microbiological culture results were tested using the Unyvero HPN Application. Performance evaluation of the HPN Application was carried out using the standard-of-care (SoC) microbiological culture findings as the reference method. Eighty-three LRT samples were used in the evaluation. The HPN Application had a full concordance with SoC findings in 59/83 (71%) samples. The new method detected additional bacterial species in 21 (25%) and failed at detecting a bacterial species present in lower respiratory culture in 3 (3.6%) samples. Overall the sensitivity, specificity, positive, and negative predictive values of the HPN Application were 95.1% (95%CI 96.5-98.3%), 98.3% (95% CI 97.5-98.9%), 71.6% (95% CI 61.0-80.3%), and 99.8% (95% CI 99.3-99.9%), respectively. In conclusion, the HPN Application demonstrated higher diagnostic yield in comparison with the culture and generated results within 5 h.", "doi": "10.1007/s10096-021-04194-6", "pmid": "33661410", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10096-021-04194-6"}, {"db": "pmc", "key": "PMC7930892"}], "notes": [], "created": "2021-03-06T10:23:44.394Z", "modified": "2021-11-18T12:18:22.450Z"}, {"entity": "publication", "iuid": "706709cf6e124a22a1aa0c37efde7172", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/706709cf6e124a22a1aa0c37efde7172.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/706709cf6e124a22a1aa0c37efde7172"}}, "title": "Swedish middle school students' psychosocial well-being during the COVID-19 pandemic: A longitudinal study.", "authors": [{"family": "Vira", "given": "Emily G", "initials": "EG"}, {"family": "Skoog", "given": "Ther\u00e9se", "initials": "T"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "SSM Popul Health", "issn": "2352-8273", "volume": "16", "pages": "100942", "issn-l": null}, "abstract": "Child well-being concerns amidst the COVID-19 pandemic have been reported from countries with strict lockdowns and school closures. Sweden's middle school students attended school as normal during the pandemic, but it is still unknown how their well-being has changed during the pandemic. This study aimed to assess differences in Swedish students' psychosocial well-being from before to during the pandemic. Longitudinal data (N = 849) were collected via self-report surveys across two time-points separated by approximately one year. The second data collection took place 8-9 months after the start of the pandemic in Sweden. We measured psychological adjustment, relationships to significant others and school adjustment. Findings revealed significant mean-level decreases in students' school adjustment during the pandemic. There were no meaningful mean-level decreases in students' relationships to significant others. Students' psychological adjustment showed significant but mostly negligible mean-level decreases, and no differences in emotional problems during the pandemic. The findings are explained based on students' developmental stage and the handling of the pandemic in the Swedish school context. Based on this first longitudinal study on students' wellbeing during the COVID-19 pandemic, we conclude that Swedish middle school students who continued formal schooling show mainly positive adaptations, and thus appear to be resilient during the COVID-19 pandemic.", "doi": "10.1016/j.ssmph.2021.100942", "pmid": "34664029", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2352-8273(21)00217-2"}, {"db": "pmc", "key": "PMC8516135"}], "notes": [], "created": "2021-10-21T04:57:18.209Z", "modified": "2021-10-21T04:57:18.231Z"}, {"entity": "publication", "iuid": "078e400f924141a7b6ac8c40f1daf541", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/078e400f924141a7b6ac8c40f1daf541.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/078e400f924141a7b6ac8c40f1daf541"}}, "title": "Revival of ecological studies during the COVID-19 pandemic.", "authors": [{"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}, {"family": "Modig", "given": "Karin", "initials": "K"}, {"family": "Kahn", "given": "Fredrik", "initials": "F"}, {"family": "Ahlbom", "given": "Anders", "initials": "A", "orcid": "0000-0003-1093-1901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f33a2deb34d945878518ba196b3f6728.json"}}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Eur J Epidemiol", "issn": "1573-7284", "volume": "36", "issue": "12", "pages": "1225-1229", "issn-l": "0393-2990"}, "abstract": null, "doi": "10.1007/s10654-021-00830-9", "pmid": "34951671", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10654-021-00830-9"}, {"db": "pmc", "key": "PMC8703212"}], "notes": [], "created": "2022-01-04T15:26:57.207Z", "modified": "2022-01-04T15:27:31.950Z"}, {"entity": "publication", "iuid": "904eec4259f24c22aa26316b21f08c15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/904eec4259f24c22aa26316b21f08c15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/904eec4259f24c22aa26316b21f08c15"}}, "title": "Respiratory infection risk-based ventilation design method.", "authors": [{"family": "Kurnitski", "given": "Jarek", "initials": "J"}, {"family": "Kiil", "given": "Martin", "initials": "M"}, {"family": "Wargocki", "given": "Pawel", "initials": "P"}, {"family": "Boerstra", "given": "Atze", "initials": "A"}, {"family": "Sepp\u00e4nen", "given": "Olli", "initials": "O"}, {"family": "Olesen", "given": "Bjarne", "initials": "B"}, {"family": "Morawska", "given": "Lidia", "initials": "L"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Build Environ", "issn": "0360-1323", "volume": "206", "pages": "108387", "issn-l": null}, "abstract": "A new design method is proposed to calculate outdoor air ventilation rates to control respiratory infection risk in indoor spaces. We propose to use this method in future ventilation standards to complement existing ventilation criteria based on the perceived air quality and pollutant removal. The proposed method makes it possible to calculate the required ventilation rate at a given probability of infection and quanta emission rate. Present work used quanta emission rates for SARS-CoV-2 and consequently the method can be applied for other respiratory viruses with available quanta data. The method was applied to case studies representing typical rooms in public buildings. To reduce the probability of infection, the total airflow rate per infectious person revealed to be the most important parameter to reduce the infection risk. Category I ventilation rate prescribed in the EN 16798-1 standard satisfied many but not all type of spaces examined. The required ventilation rates started from about 80 L/s per room. Large variations between the results for the selected case studies made it impossible to provide a simple rule for estimating the required ventilation rates. Consequently, we conclude that to design rooms with a low infection risk the newly developed ventilation design method must be used.", "doi": "10.1016/j.buildenv.2021.108387", "pmid": "34602721", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0360-1323(21)00784-8"}, {"db": "pmc", "key": "PMC8462055"}], "notes": [], "created": "2021-10-11T18:01:41.194Z", "modified": "2021-10-11T18:01:41.235Z"}, {"entity": "publication", "iuid": "ad6319278115441b8d67e949c2c8929f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ad6319278115441b8d67e949c2c8929f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ad6319278115441b8d67e949c2c8929f"}}, "title": "Patterns and predictors of sick leave after Covid-19 and long Covid in a national Swedish cohort", "authors": [{"family": "Westerlind", "given": "Emma", "initials": "E"}, {"family": "Palstam", "given": "Annie", "initials": "A"}, {"family": "Sunnerhagen", "given": "Katharina S", "initials": "KS"}, {"family": "Persson", "given": "Hanna C", "initials": "HC"}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "1023"}, "abstract": "The impact of Covid-19 and its long-term consequences is not yet fully understood. Sick leave can be seen as an indicator of health in a working age population, and the present study aimed to investigate sick-leave patterns after Covid-19, and potential factors predicting longer sick leave in hospitalised and non-hospitalised people with Covid-19.\r\n\r\nThe present study is a comprehensive national registry-based study in Sweden with a 4-month follow-up. All people who started to receive sickness benefits for Covid-19 during March 1 to August 31, 2020, were included. Predictors of sick leave \u22651 month and long Covid (\u226512 weeks) were analysed with logistic regression in the total population and in separate models depending on inpatient care due to Covid-19.\r\n\r\nA total of 11,955 people started sick leave for Covid-19 within the inclusion period. The median sick leave was 35 days, 13.3% were on sick leave for long Covid, and 9.0% remained on sick leave for the whole follow-up period. There were 2960 people who received inpatient care due to Covid-19, which was the strongest predictor of longer sick leave. Sick leave the year prior to Covid-19 and older age also predicted longer sick leave. No clear pattern of socioeconomic factors was noted.\r\n\r\nA substantial number of people are on sick leave due to Covid-19. Sick leave may be protracted, and sick leave for long Covid is quite common. The severity of Covid-19 (needing inpatient care), prior sick leave, and age all seem to predict the likelihood of longer sick leave. However, no socioeconomic factor could clearly predict longer sick leave, indicating the complexity of this condition. The group needing long sick leave after Covid-19 seems to be heterogeneous, indicating a knowledge gap.", "doi": "10.1186/s12889-021-11013-2", "pmid": "34059034", "labels": {"Category: Rehabilitation": null, "Category: Post-COVID": null, "Type: Journal article": null, "Funder: Forte": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11013-2"}], "notes": [], "created": "2021-06-02T13:13:29.154Z", "modified": "2021-11-19T10:41:14.086Z"}, {"entity": "publication", "iuid": "f3ea01c51f5943808fabda31a757f721", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f3ea01c51f5943808fabda31a757f721.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f3ea01c51f5943808fabda31a757f721"}}, "title": "Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study.", "authors": [{"family": "Sattui", "given": "Sebastian E", "initials": "SE"}, {"family": "Conway", "given": "Richard", "initials": "R"}, {"family": "Putman", "given": "Michael S", "initials": "MS"}, {"family": "Seet", "given": "Andrea M", "initials": "AM"}, {"family": "Gianfrancesco", "given": "Milena A", "initials": "MA"}, {"family": "Beins", "given": "Kaley", "initials": "K"}, {"family": "Hill", "given": "Catherine", "initials": "C"}, {"family": "Liew", "given": "David", "initials": "D"}, {"family": "Mackie", "given": "Sarah L", "initials": "SL"}, {"family": "Mehta", "given": "Puja", "initials": "P"}, {"family": "Neill", "given": "Lorna", "initials": "L"}, {"family": "Gomez", "given": "Gimena", "initials": "G"}, {"family": "Salinas", "given": "Maria Isabel Haye", "initials": "MIH"}, {"family": "Maldonado", "given": "Federico Nicolas", "initials": "FN"}, {"family": "Mariz", "given": "Henrique Ataide", "initials": "HA"}, {"family": "de Sousa Studart", "given": "Samia Araujo", "initials": "SA"}, {"family": "Araujo", "given": "Nafice Costa", "initials": "NC"}, {"family": "Knight", "given": "Ann", "initials": "A"}, {"family": "Rozza", "given": "Davide", "initials": "D"}, {"family": "Quartuccio", "given": "Luca", "initials": "L"}, {"family": "Samson", "given": "Maxime", "initials": "M"}, {"family": "Bally", "given": "St\u00e9phane", "initials": "S"}, {"family": "Maria", "given": "Alexandre Tj", "initials": "AT"}, {"family": "Chazerain", "given": "Pascal", "initials": "P"}, {"family": "Hasseli", "given": "Rebecca", "initials": "R"}, {"family": "M\u00fcller-Ladner", "given": "Ulf", "initials": "U"}, {"family": "Hoyer", "given": "Bimba F", "initials": "BF"}, {"family": "Voll", "given": "Reinhard", "initials": "R"}, {"family": "Torres", "given": "Rita Pinheiro", "initials": "RP"}, {"family": "Luis", "given": "Mariana", "initials": "M"}, {"family": "Ribeirio", "given": "Sandra Lucia Euzebio", "initials": "SLE"}, {"family": "Al-Emadi", "given": "Samar", "initials": "S"}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA"}, {"family": "Hsu", "given": "Tiffany Y-T", "initials": "TY"}, {"family": "D'Silva", "given": "Kristin M", "initials": "KM"}, {"family": "Patel", "given": "Naomi J", "initials": "NJ"}, {"family": "Wise", "given": "Leanna", "initials": "L"}, {"family": "Gilbert", "given": "Emily", "initials": "E"}, {"family": "Almada", "given": "Maria Valenzuela", "initials": "MV"}, {"family": "Duarte-Garc\u00eda", "given": "Al\u00ed", "initials": "A"}, {"family": "Ugarte-Gil", "given": "Manuel", "initials": "M"}, {"family": "Jacobsohn", "given": "Lindsay", "initials": "L"}, {"family": "Izadi", "given": "Zara", "initials": "Z"}, {"family": "Strangfeld", "given": "Anja", "initials": "A"}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL"}, {"family": "Gossec", "given": "Laure", "initials": "L"}, {"family": "Carmona", "given": "Loreto", "initials": "L"}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S"}, {"family": "Kearsley-Fleet", "given": "Lianne", "initials": "L"}, {"family": "Schaefer", "given": "Martin", "initials": "M"}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS"}, {"family": "Sufka", "given": "Paul", "initials": "P"}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Grainger", "given": "Rebecca", "initials": "R"}, {"family": "Machado", "given": "Pedro M", "initials": "PM"}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Yazdany", "given": "Jinoos", "initials": "J"}, {"family": "Robinson", "given": "Philip C", "initials": "PC"}, {"family": "Global Rheumatology Alliance", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Lancet Rheumatol", "issn": "2665-9913", "volume": "3", "issue": "12", "pages": "e855-e864", "issn-l": null}, "abstract": "Patients with primary systemic vasculitis or polymyalgia rheumatica might be at a high risk for poor COVID-19 outcomes due to the treatments used, the potential organ damage cause by primary systemic vasculitis, and the demographic factors associated with these conditions. We therefore aimed to investigate factors associated with COVID-19 outcomes in patients with primary systemic vasculitis or polymyalgia rheumatica.\n\nIn this retrospective cohort study, adult patients (aged \u226518 years) diagnosed with COVID-19 between March 12, 2020, and April 12, 2021, who had a history of primary systemic vasculitis (antineutrophil cytoplasmic antibody [ANCA]-associated vasculitis, giant cell arteritis, Beh\u00e7et's syndrome, or other vasculitis) or polymyalgia rheumatica, and were reported to the COVID-19 Global Rheumatology Alliance registry were included. To assess COVID-19 outcomes in patients, we used an ordinal COVID-19 severity scale, defined as: (1) no hospitalisation; (2) hospitalisation without supplemental oxygen; (3) hospitalisation with any supplemental oxygen or ventilation; or (4) death. Multivariable ordinal logistic regression analyses were used to estimate odds ratios (ORs), adjusting for age, sex, time period, number of comorbidities, smoking status, obesity, glucocorticoid use, disease activity, region, and medication category. Analyses were also stratified by type of rheumatic disease.\n\nOf 1202 eligible patients identified in the registry, 733 (61\u00b70%) were women and 469 (39\u00b70%) were men, and their mean age was 63\u00b78 years (SD 17\u00b71). A total of 374 (31\u00b71%) patients had polymyalgia rheumatica, 353 (29\u00b74%) had ANCA-associated vasculitis, 183 (15\u00b72%) had giant cell arteritis, 112 (9\u00b73%) had Beh\u00e7et's syndrome, and 180 (15\u00b70%) had other vasculitis. Of 1020 (84\u00b79%) patients with outcome data, 512 (50\u00b72%) were not hospitalised, 114 (11\u00b72%) were hospitalised and did not receive supplemental oxygen, 239 (23\u00b74%) were hospitalised and received ventilation or supplemental oxygen, and 155 (15\u00b72%) died. A higher odds of poor COVID-19 outcomes were observed in patients who were older (per each additional decade of life OR 1\u00b744 [95% CI 1\u00b731-1\u00b757]), were male compared with female (1\u00b738 [1\u00b705-1\u00b780]), had more comorbidities (per each additional comorbidity 1\u00b739 [1\u00b723-1\u00b758]), were taking 10 mg/day or more of prednisolone compared with none (2\u00b714 [1\u00b750-3\u00b704]), or had moderate, or high or severe disease activity compared with those who had disease remission or low disease activity (2\u00b712 [1\u00b749-3\u00b702]). Risk factors varied among different disease subtypes.\n\nAmong patients with primary systemic vasculitis and polymyalgia rheumatica, severe COVID-19 outcomes were associated with variable and largely unmodifiable risk factors, such as age, sex, and number of comorbidities, as well as treatments, including high-dose glucocorticoids. Our results could be used to inform mitigation strategies for patients with these diseases.\n\nAmerican College of Rheumatology and the European Alliance of Associations for Rheumatology.", "doi": "10.1016/S2665-9913(21)00316-7", "pmid": "34778843", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2665-9913(21)00316-7"}, {"db": "pmc", "key": "PMC8570701"}], "notes": [], "created": "2021-11-26T14:13:12.026Z", "modified": "2021-11-26T14:13:12.041Z"}, {"entity": "publication", "iuid": "74a2d3a88e74486eb9d5899b4fbb201d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/74a2d3a88e74486eb9d5899b4fbb201d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/74a2d3a88e74486eb9d5899b4fbb201d"}}, "title": "Nudging healthcare professionals to improve treatment of COVID-19: a narrative review", "authors": [{"family": "Vilhelmsson", "given": "Andreas", "initials": "A", "orcid": "0000-0002-6635-8182", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48e38ddf17384577a77c07639249ecc8.json"}}, {"family": "Sant'Anna", "given": "Anita", "initials": "A"}, {"family": "Wolf", "given": "Axel", "initials": "A"}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "BMJ Open Qual", "issn": "2399-6641", "volume": "10", "issue": "4", "pages": "e001522", "issn-l": null}, "abstract": null, "doi": "10.1136/bmjoq-2021-001522", "pmid": null, "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:54:04.021Z", "modified": "2021-12-12T06:54:04.271Z"}, {"entity": "publication", "iuid": "5d2e70aff6164745ab02cd7192646084", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d2e70aff6164745ab02cd7192646084.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d2e70aff6164745ab02cd7192646084"}}, "title": "Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms.", "authors": [{"family": "Zhong", "given": "Wen", "initials": "W"}, {"family": "Altay", "given": "Ozlem", "initials": "O"}, {"family": "Arif", "given": "Muhammad", "initials": "M"}, {"family": "Edfors", "given": "Fredrik", "initials": "F"}, {"family": "Doganay", "given": "Levent", "initials": "L"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A"}, {"family": "Uhlen", "given": "Mathias", "initials": "M"}, {"family": "Fagerberg", "given": "Linn", "initials": "L", "orcid": "0000-0003-0198-7137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/735a371341c246a88f09c1efea5a5f57.json"}}], "type": "clinical trial, phase ii", "published": "2021-12-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "volume": "74", "pages": "103723", "issn-l": null}, "abstract": "COVID-19 has caused millions of deaths globally, yet the cellular mechanisms underlying the various effects of the disease remain poorly understood. Recently, a new analytical platform for comprehensive analysis of plasma protein profiles using proximity extension assays combined with next generation sequencing has been developed, which allows for multiple proteins to be analyzed simultaneously without sacrifice on accuracy or sensitivity.\n\nWe analyzed the plasma protein profiles of COVID-19 patients (n = 50) with mild and moderate symptoms by comparing the protein levels in newly diagnosed patients with the protein levels in the same individuals after 14 days.\n\nThe study has identified more than 200 proteins that are significantly elevated during infection and many of these are related to cytokine response and other immune-related functions. In addition, several other proteins are shown to be elevated, including SCARB2, a host cell receptor protein involved in virus entry. A comparison with the plasma protein response in patients with severe symptoms shows a highly similar pattern, but with some interesting differences.\n\nThe study presented here demonstrates the usefulness of \"next generation plasma protein profiling\" to identify molecular signatures of importance for disease progression and to allow monitoring of disease during recovery from the infection. The results will facilitate further studies to understand the molecular mechanism of the immune-related response of the SARS-CoV-2 virus.\n\nThis work was financially supported by Knut and Alice Wallenberg Foundation.", "doi": "10.1016/j.ebiom.2021.103723", "pmid": "34844191", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8626206"}, {"db": "pii", "key": "S2352-3964(21)00517-X"}], "notes": [], "created": "2021-12-18T18:11:33.370Z", "modified": "2023-06-19T15:39:44.480Z"}, {"entity": "publication", "iuid": "635551968c97474e8cc1a35c1be3193d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/635551968c97474e8cc1a35c1be3193d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/635551968c97474e8cc1a35c1be3193d"}}, "title": "National health governance, science and the media: drivers of COVID-19 responses in Germany, Sweden and the UK in 2020.", "authors": [{"family": "Hanson", "given": "Claudia", "initials": "C", "orcid": "0000-0001-8066-7873", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c06a2e703c840788ccdf3b2c4c972bc.json"}}, {"family": "Luedtke", "given": "Susanne", "initials": "S"}, {"family": "Spicer", "given": "Neil", "initials": "N"}, {"family": "Stilhoff S\u00f6rensen", "given": "Jens", "initials": "J"}, {"family": "Mayhew", "given": "Susannah", "initials": "S"}, {"family": "Mounier-Jack", "given": "Sandra", "initials": "S"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "12", "issn-l": "2059-7908"}, "abstract": "The COVID-19 pandemic is an unprecedented global crisis in which governments had to act in a situation of rapid change and substantial uncertainty. The governments of Germany, Sweden and the UK have taken different paths allowing learning for future pandemic preparedness. To help inform discussions on preparedness, inspired by resilience frameworks, this paper reviews governance structures, and the role of science and the media in the COVID-19 response of Germany, Sweden and the UK in 2020. We mapped legitimacy, interdependence, knowledge generation and the capacity to deal with uncertainty.Our analysis revealed stark differences which were linked to pre-existing governing structures, the traditional role of academia, experience of crisis management and the communication of uncertainty-all of which impacted on how much people trusted their government. Germany leveraged diversity and inclusiveness, a 'patchwork quilt', for which it was heavily criticised during the second wave. The Swedish approach avoided plurality and largely excluded academia, while in the UK's academia played an important role in knowledge generation and in forcing the government to review its strategies. However, the vivant debate left the public with confusing and rapidly changing public health messages. Uncertainty and the lack of evidence on how best to manage the COVID-19 pandemic-the main feature during the first wave-was only communicated explicitly in Germany. All country governments lost trust of their populations during the epidemic due to a mix of communication and transparency failures, and increased questioning of government legitimacy and technical capacity by the public.", "doi": "10.1136/bmjgh-2021-006691", "pmid": "34872972", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8764706"}, {"db": "pii", "key": "bmjgh-2021-006691"}], "notes": [], "created": "2021-12-12T07:10:21.949Z", "modified": "2023-01-13T13:28:12.610Z"}, {"entity": "publication", "iuid": "a957c1c71ff2471b879730385ff59136", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a957c1c71ff2471b879730385ff59136.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a957c1c71ff2471b879730385ff59136"}}, "title": "More than 50 long-term effects of COVID-19: a systematic review and meta-analysis", "authors": [{"family": "Lopez-Leon", "given": "Sandra", "initials": "S", "orcid": "0000-0001-7504-3441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/311cfec51fe9447283ee5c3a4ca0a3cd.json"}}, {"family": "Wegman-Ostrosky", "given": "Talia", "initials": "T", "orcid": "0000-0002-3207-6697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ebacfc4db6e4a04aab46b7172d828f2.json"}}, {"family": "Perelman", "given": "Carol", "initials": "C", "orcid": "0000-0002-0111-1154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb4874d2c45c4d698c57f5e3705d306d.json"}}, {"family": "Sepulveda", "given": "Rosalinda", "initials": "R", "orcid": "0000-0003-1146-9552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e217c9ab8c24eeca127ffb1dd89b843.json"}}, {"family": "Rebolledo", "given": "Paulina A", "initials": "PA", "orcid": "0000-0002-9808-063X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bbee43f79e147b39028119e0b573c72.json"}}, {"family": "Cuapio", "given": "Angelica", "initials": "A", "orcid": "0000-0002-9451-1914", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f4915fdfa7d460f9b705b56b0fc1c4a.json"}}, {"family": "Villapol", "given": "Sonia", "initials": "S", "orcid": "0000-0002-6174-4113", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04eb73dcc16546b0b153a41bcba039af.json"}}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": null}, "abstract": null, "doi": "10.1038/s41598-021-95565-8", "pmid": null, "labels": {"Type: Preprint": null, "Type: Review": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-17T19:33:26.821Z", "modified": "2022-07-06T04:52:15.537Z"}, {"entity": "publication", "iuid": "508d0a8b8a5a4f6684354585ced2f945", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/508d0a8b8a5a4f6684354585ced2f945.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/508d0a8b8a5a4f6684354585ced2f945"}}, "title": "Measuring changes in alcohol use in Finland and Norway during the COVID-19 pandemic: Comparison between data sources.", "authors": [{"family": "M\u00e4kel\u00e4", "given": "Pia", "initials": "P", "orcid": "0000-0002-3343-2139", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c978b04d84144cb694a974c01022890b.json"}}, {"family": "Rossow", "given": "Ingeborg", "initials": "I", "orcid": "0000-0001-8652-9367", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab426c14c36143d0bd2da8eb86f74e97.json"}}, {"family": "Moan", "given": "Inger Synn\u00f8ve", "initials": "IS", "orcid": "0000-0002-9021-8665", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fd744b5fb9f46e6868ab5b624ce81e4.json"}}, {"family": "Bye", "given": "Elin K", "initials": "EK", "orcid": "0000-0001-7559-8885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98e8956f35d94c1c8142605e7cdb51f7.json"}}, {"family": "Kilian", "given": "Carolin", "initials": "C", "orcid": "0000-0001-5913-6488", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed0409bb90b346cd9001bebb46bdcf87.json"}}, {"family": "Raitasalo", "given": "Kirsimarja", "initials": "K", "orcid": "0000-0001-7909-8562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28001f1928d44b98af9bd7d509477ae3.json"}}, {"family": "Allebeck", "given": "Peter", "initials": "P", "orcid": "0000-0002-2778-6467", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de9f0e1c3e4d402b93e61ad1c5a771fb.json"}}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Int J Methods Psychiatr Res", "issn": "1557-0657", "issn-l": null, "volume": "30", "issue": "4", "pages": "e1892"}, "abstract": "To examine (1) how a rapid data collection using a convenience sample fares in estimating change in alcohol consumption when compared to more conventional data sources, and (2) how alcohol consumption changed in Finland and Norway during the first months of the COVID-19 pandemic.\n\nThree different types of data sources were used for the 2nd quarter of 2020 and 2019: sales statistics combined with data on unrecorded consumption; the rapid European Alcohol Use and COVID-19 (ESAC) survey (Finland: n = 3800, Norway: n = 17,092); and conventional population surveys (Finland: n = 2345, Norway: n1 = 1328, n2 = 2189, n3 = 25,708). Survey measures of change were retrospective self-reports.\n\nThe statistics indicate that alcohol consumption decreased in Finland by 9%, while little change was observed in Norway. In all surveys, reporting a decrease in alcohol use was more common than reporting an increase (ratios 2-2.6 in Finland, 1.3-2 in Norway). Compared to conventional surveys, in the ESAC survey fewer respondents reported no change and past-year alcohol consumption was higher.\n\nThe rapid survey using convenience sampling gave similar results on change in drinking as conventional surveys but higher past-year drinking, suggesting self-selection effects. Aspects of the pandemic driving alcohol consumption down were equally strong or stronger than those driving it up.", "doi": "10.1002/mpr.1892", "pmid": "34449127", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8633923"}], "notes": [], "created": "2021-09-01T07:29:54.053Z", "modified": "2023-06-19T07:32:29.877Z"}, {"entity": "publication", "iuid": "e3b9bb4510224866b575e818109cc8b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3b9bb4510224866b575e818109cc8b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3b9bb4510224866b575e818109cc8b0"}}, "title": "Mapping the human genetic architecture of COVID-19.", "authors": [{"family": "COVID-19 Host Genetics Initiative", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Nature", "issn": "1476-4687", "issn-l": "0028-0836", "volume": "600", "issue": "7889", "pages": "472-477"}, "abstract": "The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3-7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.", "doi": "10.1038/s41586-021-03767-x", "pmid": "34237774", "labels": {"Funder: VR": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Research Area: Vaccine": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41586-021-03767-x"}, {"db": "pmc", "key": "PMC8674144"}], "notes": [], "created": "2021-08-06T10:53:44.989Z", "modified": "2022-02-06T17:38:20.820Z"}, {"entity": "publication", "iuid": "b8e256df3ccd48239acb1ee143624cfb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8e256df3ccd48239acb1ee143624cfb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8e256df3ccd48239acb1ee143624cfb"}}, "title": "Managers of micro-sized enterprises and Covid-19: impact on business operations, work-life balance and well-being.", "authors": [{"family": "Vinberg", "given": "Stig", "initials": "S", "orcid": "0000-0002-5935-5688", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c63c4ca58d242d18741dba0b0af5afb.json"}}, {"family": "Danielsson", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Int J Circumpolar Health", "issn": "2242-3982", "volume": "80", "issue": "1", "pages": "1959700", "issn-l": null}, "abstract": "The aim of this study is to identify how managers of micro-sized enterprises experience the impact of the Covid-19 pandemic on their business operations, work-life balance and well-being. Further, the study aims to make comparisons between managers of micro-sized businesses and managers of small-sized businesses. This mixed-method study is based on qualitative interviews with ten managers of micro-sized enterprises and a questionnaire answered by 95 managers of micro-sized and small-sized enterprises in regions in the north of Sweden. Managers of micro-sized enterprises reported significantly worse scores for mental well-being, job satisfaction and life satisfaction in comparison with managers of small-sized enterprises. Three themes emerged from the qualitative analysis: Changed leadership role, Impact on private life and Impact on well-being. In the interviews, the managers of micro-sized enterprises reported that the pandemic had increased their workload and forced them to mobilise strategies for enterprise survival. This study indicates that managers of micro-sized enterprises had changed their leadership role and increased their workload and number of work tasks, including supporting the employees, developing strategies for business survival and applying for governmental support. However, the managers demonstrated creativity in finding new solutions for their enterprises.", "doi": "10.1080/22423982.2021.1959700", "pmid": "34378496", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-08-12T17:06:29.217Z", "modified": "2021-08-12T17:08:20.118Z"}, {"entity": "publication", "iuid": "ea0c1b175467424bbc1e77816c8aa57d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ea0c1b175467424bbc1e77816c8aa57d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ea0c1b175467424bbc1e77816c8aa57d"}}, "title": "Insecurity, lack of support, and frustration: A sociological analysis of how three groups of students reflect on their distance education during the pandemic in Sweden.", "authors": [{"family": "Lidegran", "given": "Ida", "initials": "I", "orcid": "0000-0003-3193-5565", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d260c6beaac7465ea0a6c426ee30008f.json"}}, {"family": "Hultqvist", "given": "Elisabeth", "initials": "E"}, {"family": "Bertilsson", "given": "Emil", "initials": "E"}, {"family": "B\u00f6rjesson", "given": "Mikael", "initials": "M"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Eur J Educ", "issn": "1465-3435", "issn-l": null, "volume": "56", "issue": "4", "pages": "550-563"}, "abstract": "This article investigates the situation of Swedish upper secondary school students who have been subject to distance education during the COVID-19 pandemic crisis. We understand the transition from onsite education to distance education as a recontextualization of pedagogical practice, our framing follows loosely concepts from Bernstein. Given that the field of upper secondary education is highly socially structured it is relevant to enquire into the social dimensions of distance education. For this purpose, we have analysed answers to an open-ended question in a survey answered by 3,726 students, and related them to a cluster analysis distinguishing three main clusters of students: urban upper-middle-class, immigrant working-class, and rural working-class. The urban upper-middle-class students experienced problems decoding new requirements and were troubled by blurred boundaries between school and home. This group invests the most in schooling, and therefore expresses comparatively more anxiety for reaching anticipated achievements. Immigrant working-class students were comparatively more discontented by a lack of school support and request clearer instructions. In this new educational situation, characterized by a weak framing, they have difficulties decoding the requirements. The rural working-class students appear comparatively more disconnected from the school situation. Unlike urban upper-middle-class students, for whom the school invades the home and private sphere, the rural working-class students seldom experienced that the school intruded their home; accordingly, their studies collapsed into sleep-in-mornings and a holiday feeling.", "doi": "10.1111/ejed.12477", "pmid": "34898738", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "EJED12477"}, {"db": "pmc", "key": "PMC8646562"}], "notes": [], "created": "2021-12-18T18:00:37.973Z", "modified": "2022-11-22T05:44:45.823Z"}, {"entity": "publication", "iuid": "086c3c198dec478c9ddc11bc755e5ff8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/086c3c198dec478c9ddc11bc755e5ff8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/086c3c198dec478c9ddc11bc755e5ff8"}}, "title": "Initial assessment of the COVID-19 vaccination's impact on case numbers, hospitalisations and deaths in people aged 80 years and older, 15 EU/EEA countries, December 2020 to May 2021.", "authors": [{"family": "Nicolay", "given": "Nathalie", "initials": "N"}, {"family": "Innocenti", "given": "Francesco", "initials": "F"}, {"family": "Beaut\u00e9", "given": "Julien", "initials": "J"}, {"family": "U\u010dakar", "given": "Veronika", "initials": "V"}, {"family": "Grgi\u010d Vitek", "given": "Marta", "initials": "M"}, {"family": "Poukka", "given": "Eero", "initials": "E"}, {"family": "Hannila-Handelberg", "given": "Tuula", "initials": "T"}, {"family": "Gauci", "given": "Charmaine", "initials": "C"}, {"family": "Melillo", "given": "Tanya", "initials": "T"}, {"family": "Georgakopoulou", "given": "Theano", "initials": "T"}, {"family": "Jarkovsky", "given": "Jiri", "initials": "J"}, {"family": "Slezak", "given": "Pavel", "initials": "P"}, {"family": "Delgado-Sanz", "given": "Concepci\u00f3n", "initials": "C"}, {"family": "Olmedo-Lucer\u00f3n", "given": "Carmen", "initials": "C"}, {"family": "Suija", "given": "Heleene", "initials": "H"}, {"family": "Liausediene", "given": "Rasa", "initials": "R"}, {"family": "O'Lorcain", "given": "Piaras", "initials": "P"}, {"family": "Murphy", "given": "Niamh", "initials": "N"}, {"family": "Peralta-Santos", "given": "Andr\u00e9", "initials": "A"}, {"family": "Casaca", "given": "Pedro", "initials": "P"}, {"family": "Gregoriou", "given": "Ioanna", "initials": "I"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Spiteri", "given": "Gianfranco", "initials": "G"}, {"family": "Ravasi", "given": "Giovanni", "initials": "G"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "48", "issn-l": null}, "abstract": "Prioritisation of elderly people in COVID-19 vaccination campaigns aimed at reducing severe outcomes in this group. Using EU/EEA surveillance and vaccination uptake, we estimated the risk ratio of case, hospitalisation and death notifications in people 80 years and older compared with 25-59-year-olds. Highest impact was observed for full vaccination uptake 80% or higher with reductions in notification rates of cases up to 65% (IRR: 0.35; 95% CI: 0.13-0.99), hospitalisations up to 78% (IRR: 0.22; 95% CI: 0.13-0.37) and deaths up to 84% (IRR: 0.16; 95% CI: 0.13-0.20).", "doi": "10.2807/1560-7917.ES.2021.26.48.2101030", "pmid": "34857068", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8641072"}], "notes": [], "created": "2021-12-18T18:07:47.120Z", "modified": "2021-12-18T18:07:47.135Z"}, {"entity": "publication", "iuid": "9288b382d01b42629711ac1c5ae10c9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9288b382d01b42629711ac1c5ae10c9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9288b382d01b42629711ac1c5ae10c9c"}}, "title": "Human papillomavirus vaccination in the European Union/European Economic Area and globally: a moral dilemma.", "authors": [{"family": "Colzani", "given": "Edoardo", "initials": "E"}, {"family": "Johansen", "given": "Kari", "initials": "K"}, {"family": "Johnson", "given": "Helen", "initials": "H"}, {"family": "Pastore Celentano", "given": "Lucia", "initials": "L"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "50", "issn-l": null}, "abstract": "While many European Union/European Economic Area (EU/EEA) countries recently expanded human papillomavirus (HPV) vaccination to boys, HPV vaccine supply is currently limited for girls in low- and middle-income countries (LMIC) that are severely affected by HPV.Globally, about 50% of countries have introduced HPV vaccination. Some LMIC with high burden of cervical cancer have not yet introduced HPV vaccination, or are reaching suboptimal vaccination coverage. While WHO issued a call for cervical cancer elimination in 2018, a global shortage of HPV vaccines is currently predicted to last at least until 2024.We reviewed national policies of EU/EEA countries and recommendations of the World Health Organization (WHO) Strategic Advisory Group of Experts on immunisation to discuss current challenges and dose-sparing options. Several EU/EEA countries have extended HPV vaccination to boys and the European Cancer Organisation has issued a resolution for elimination of all HPV-associated cancers in both sexes. The European Centre for Disease Prevention and Control concluded in its 2020 guidance that cost-effectiveness of extending routine vaccination to boys depends on several context-specific factors. The extension of HPV vaccination to boys in EU/EEA countries may affect global availability of vaccines. Temporary dose-sparing options could be considered during the COVID-19 post-pandemic period.", "doi": "10.2807/1560-7917.ES.2021.26.50.2001659", "pmid": "34915976", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T17:44:17.021Z", "modified": "2021-12-18T17:44:17.034Z"}, {"entity": "publication", "iuid": "5d377c22678c463fb0fcddfaf34db158", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d377c22678c463fb0fcddfaf34db158.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d377c22678c463fb0fcddfaf34db158"}}, "title": "Epidemiological characterisation of the first 785 SARS-CoV-2 Omicron variant cases in Denmark, December 2021.", "authors": [{"family": "Espenhain", "given": "Laura", "initials": "L"}, {"family": "Funk", "given": "Tjede", "initials": "T"}, {"family": "Overvad", "given": "Maria", "initials": "M"}, {"family": "Edslev", "given": "Sofie Marie", "initials": "SM"}, {"family": "Fonager", "given": "Jannik", "initials": "J"}, {"family": "Ingham", "given": "Anna C\u00e4cilia", "initials": "AC"}, {"family": "Rasmussen", "given": "Morten", "initials": "M"}, {"family": "Madsen", "given": "Sarah Leth", "initials": "SL"}, {"family": "Espersen", "given": "Caroline Hjorth", "initials": "CH"}, {"family": "Sieber", "given": "Raphael N", "initials": "RN"}, {"family": "Stegger", "given": "Marc", "initials": "M"}, {"family": "Gunalan", "given": "Vithiagaran", "initials": "V"}, {"family": "Wilkowski", "given": "Bartlomiej", "initials": "B"}, {"family": "Larsen", "given": "Nicolai Balle", "initials": "NB"}, {"family": "Legarth", "given": "Rebecca", "initials": "R"}, {"family": "Cohen", "given": "Arieh Sierra", "initials": "AS"}, {"family": "Nielsen", "given": "Finn", "initials": "F"}, {"family": "Lam", "given": "Janni Uyen Hoa", "initials": "JUH"}, {"family": "Lavik", "given": "Kjetil Erdogan", "initials": "KE"}, {"family": "Karakis", "given": "Marianne", "initials": "M"}, {"family": "Spiess", "given": "Katja", "initials": "K"}, {"family": "Marving", "given": "Ellinor", "initials": "E"}, {"family": "Nielsen", "given": "Christian", "initials": "C"}, {"family": "Wiid Svarrer", "given": "Christina", "initials": "C"}, {"family": "Bybjerg-Grauholm", "given": "Jonas", "initials": "J"}, {"family": "Olsen", "given": "Stefan Schytte", "initials": "SS"}, {"family": "Jensen", "given": "Anders", "initials": "A"}, {"family": "Krause", "given": "Tyra Grove", "initials": "TG"}, {"family": "M\u00fcller", "given": "Luise", "initials": "L"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "50", "issn-l": null}, "abstract": "By 9 December 2021, 785 SARS-CoV-2 Omicron variant cases have been identified in Denmark. Most cases were fully (76%) or booster-vaccinated (7.1%); 34 (4.3%) had a previous SARS-CoV-2 infection. The majority of cases with available information reported symptoms (509/666; 76%) and most were infected in Denmark (588/644; 91%). One in five cases cannot be linked to previous cases, indicating widespread community transmission. Nine cases have been hospitalised, one required intensive care and no deaths have been registered.", "doi": "10.2807/1560-7917.ES.2021.26.50.2101146", "pmid": "34915977", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T17:42:47.527Z", "modified": "2021-12-18T17:42:47.539Z"}, {"entity": "publication", "iuid": "ce16ae5550dd4daf93f8efb4d2fe95dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ce16ae5550dd4daf93f8efb4d2fe95dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ce16ae5550dd4daf93f8efb4d2fe95dd"}}, "title": "Digital media content and co-viewing amongst Swedish 4- to 6-year-olds during COVID-19 pandemic.", "authors": [{"family": "Sundqvist", "given": "Annette", "initials": "A", "orcid": "0000-0001-9611-6523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1ee75c32ea3490d9c8f4f8d60c1005a.json"}}, {"family": "Heimann", "given": "Mikael", "initials": "M", "orcid": "0000-0001-5025-9975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58e5802e62bb41f28642119aab148b35.json"}}], "type": "letter", "published": "2021-12-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": "110", "issue": "12", "pages": "3329-3330"}, "abstract": "COVID-19 restrictions have increased the use of digital media and studies have suggested that children's screen time has increased by 10 hours a week since the pandemic.1 However, screen time is a very basic measure and it is also important to consider the content and context of digital media. Digital media may have negative effects on behaviour, language and memory,2,3 but this may be moderated by the positive effects of joint media engagement between children and their parents.", "doi": "10.1111/apa.16090", "pmid": "34469600", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC8653155"}], "notes": [], "created": "2021-09-06T15:53:34.789Z", "modified": "2023-06-19T14:54:35.006Z"}, {"entity": "publication", "iuid": "c42cd7518bcc45228097ec02379a869e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c42cd7518bcc45228097ec02379a869e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c42cd7518bcc45228097ec02379a869e"}}, "title": "Differences in risk for SARS-CoV-2 infection among healthcare workers", "authors": [{"family": "Elfstr\u00f6m", "given": "K Miriam", "initials": "KM"}, {"family": "Blomqvist", "given": "Jonas", "initials": "J"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Pimenoff", "given": "Ville N", "initials": "VN", "orcid": "0000-0002-0813-7031", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6df74f265514d7b8fa216d9bad0ead6.json"}}, {"family": "Arroyo M\u00fchr", "given": "Laila Sara", "initials": "LS"}, {"family": "Lundgren", "given": "Kalle Conneryd", "initials": "KC"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "Prev Med Rep", "issn": "2211-3355", "issn-l": null, "volume": "24", "issue": null, "pages": "101518"}, "abstract": "Healthcare workers (HCWs) are a risk group for SARS-CoV-2 infection, but which healthcare work that conveys risk and to what extent such risk can be prevented is not clear. Starting on April 24th, 2020, all employees at work (n = 15,300) at the Karolinska University Hospital, Stockholm, Sweden were invited and 92% consented to participate in a SARS-CoV-2 cohort study. Complete SARS-CoV-2 serology was available for n = 12,928 employees and seroprevalences were analyzed by age, sex, profession, patient contact, and hospital department. Relative risks were estimated to examine the association between type of hospital department as a proxy for different working environment exposure and risk for seropositivity, adjusting for age, sex, sampling week, and profession. Wards that were primarily responsible for COVID-19 patients were at increased risk (adjusted OR 1.95 (95% CI 1.65-2.32) with the notable exception of the infectious diseases and intensive care units (adjusted OR 0.86 (95% CI 0.66-1.13)), that were not at increased risk despite being highly exposed. Several units with similar types of work varied greatly in seroprevalences. Among the professions examined, nurse assistants had the highest risk (adjusted OR 1.62 (95% CI 1.38-1.90)). Although healthcare workers, in particular nurse assistants, who attend to COVID-19 patients are a risk group for SARS-CoV-2 infection, several units caring for COVID-19 patients had no excess risk. Large variations in seroprevalences among similar units suggest that healthcare work-related risk of SARS-CoV-2 infection may be preventable.", "doi": "10.1016/j.pmedr.2021.101518", "pmid": "34458081", "labels": {"Funder: KAW/SciLifeLab": null, "Category: Health": null, "Research Area: High-throughput and high-content serology": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2211-3355(21)00208-4"}, {"db": "pmc", "key": "PMC8379088"}], "notes": [], "created": "2021-04-10T07:52:23.920Z", "modified": "2022-02-06T17:35:15.389Z"}, {"entity": "publication", "iuid": "da5951f63d5744ed9f8e6bb8a6b7df0c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/da5951f63d5744ed9f8e6bb8a6b7df0c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/da5951f63d5744ed9f8e6bb8a6b7df0c"}}, "title": "Depression, anxiety and suicidal behaviour among college students: Comparisons pre-COVID-19 and during the pandemic.", "authors": [{"family": "McLafferty", "given": "Margaret", "initials": "M"}, {"family": "Brown", "given": "Natasha", "initials": "N"}, {"family": "McHugh", "given": "Rachel", "initials": "R"}, {"family": "Ward", "given": "Caoimhe", "initials": "C"}, {"family": "Stevenson", "given": "Ailis", "initials": "A"}, {"family": "McBride", "given": "Louise", "initials": "L"}, {"family": "Brady", "given": "John", "initials": "J"}, {"family": "Bjourson", "given": "Anthony J", "initials": "AJ"}, {"family": "O'Neill", "given": "Siobhan M", "initials": "SM"}, {"family": "Walsh", "given": "Colum P", "initials": "CP"}, {"family": "Murray", "given": "Elaine K", "initials": "EK"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Psychiatry Res Commun", "issn": "2772-5987", "volume": "1", "issue": "2", "pages": "100012", "issn-l": null}, "abstract": "Many students struggle with psychological problems during their college years. These problems may be even more apparent during the COVID-19 pandemic with the accompanying restrictions and transition to an online learning environment, but few longitudinal studies have been conducted to date. The aim of this study was to compare symptoms of depression, anxiety and suicidality prior to and during the pandemic, and identify stressors.\n\nThis study was conducted among students attending Ulster University, Northern Ireland (NI) and LYIT, Republic of Ireland (ROI), as part of the World Mental Health International College Student Initiative (WMH-ICS). Data was collected from first year students in September 2019. The completed response rate was 25.22% (NI) and 41.9% (ROI) in relation to the number of first-year students registered. A follow up study was conducted in Autumn 2020, with 884 students fully completing the online survey in both years, equating to just under half of those who completed initially.\n\nHigh levels of mental health problems were found in year 1, especially in the ROI. Levels of depression increased significantly in year 2, particularly among students in NI, however, levels of anxiety decreased. No significant variations were found for suicidal behaviour. Several stressors were revealed, including increased social isolation, and worrying about loved ones.\n\nThe findings may not be generalised to other student populations.\n\nThis study reveals variation in symptoms of depression and anxiety since the onset of the pandemic. In particular, the large increase in students with depression is of concern.", "doi": "10.1016/j.psycom.2021.100012", "pmid": "34977911", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2772-5987(21)00012-X"}, {"db": "pmc", "key": "PMC8574925"}], "notes": [], "created": "2022-01-04T14:43:28.782Z", "modified": "2022-01-04T14:43:28.821Z"}, {"entity": "publication", "iuid": "7b60e6c3be494a6c9e59e8b83866fa06", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b60e6c3be494a6c9e59e8b83866fa06.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b60e6c3be494a6c9e59e8b83866fa06"}}, "title": "Clinical outcomes in cancer patients with COVID-19 in Sweden.", "authors": [{"family": "Bondeson", "given": "Lisa", "initials": "L"}, {"family": "Thulin", "given": "Anna", "initials": "A"}, {"family": "Ny", "given": "Lars", "initials": "L", "orcid": "0000-0003-3864-5958", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/861e0a04f51e453ca92d6cca8624e187.json"}}, {"family": "Levin", "given": "Max", "initials": "M"}, {"family": "Svensson", "given": "Johanna", "initials": "J"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Zhao", "given": "Zhiyuan", "initials": "Z", "orcid": "0000-0002-6962-1791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/540e3389bb044d9991e81a68320dd224.json"}}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Acta Oncol", "issn": "1651-226X", "pages": "1572-1579", "volume": "60", "issue": "12", "issn-l": null}, "abstract": "The results of studies on the relationship between cancer and COVID-19 have been conflicting and therefore further studies are needed. We aimed to examine the incidence of COVID-19 among patients at one of the largest oncology departments in Sweden, and to evaluate and identify risk factors for poor outcomes, hospital care and death, associated with COVID-19 among cancer patients.\n\nThis retrospective study included cancer patients at a single center who tested positive for SARS-CoV-2 by PCR either in hospital, primary health care center or commercial laboratory between 1 March and 14 August 2020. Clinical and demographic data were collected from the medical records. Logistic regression analysis was used to identify variables that associated the primary outcomes of need for hospital care and death within 30 days of positive test.\n\nOf 10,774 patients from the Department of Oncology at Sahlgrenska University Hospital, 135 tested positive for SARS-CoV-2 (1.3%). Twenty-eight patients were excluded from further the data collection since they did not meet the inclusion criteria. Altogether, 107 cancer patients were included and the case fatality rate (CFR) was 12% (13) within 30 days of confirmed SARS-CoV-2 infection by PCR. Increasing years of age (OR 1.10; CI 95% 1.03-1.18), palliative treatment intent (OR 15.7; CI 95% 1.8-135.8), and transition to end-of-life care (OR 52.0; CI 95% 3.7-735.6) were associated with increased odds of death within 30 days. Male sex was associated with needing hospital care (OR 3.7; CI 95% 1.50-9.1).\n\nAs in the general population, male sex was found to be at greater risk of needing hospital care for COVID-19, with terminal cancer disease, and older age increasing the odds of fatality. Compared to the general population, slightly more cancer patients had COVID-19. The CFR was within the lower range of others reported in cancer patients.", "doi": "10.1080/0284186X.2021.1973679", "pmid": "34530692", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-09-20T16:54:02.162Z", "modified": "2023-01-13T13:30:58.420Z"}, {"entity": "publication", "iuid": "cad95e26023141d3a2014a198a44eea6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cad95e26023141d3a2014a198a44eea6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cad95e26023141d3a2014a198a44eea6"}}, "title": "Characteristics and definitive outcomes of COVID-19 patients admitted to a secondary hospital intensive care unit in Sweden.", "authors": [{"family": "Sj\u00f6str\u00f6m", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-5671-2563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7135a88659334a8eba1250f0caa3941c.json"}}, {"family": "M\u00e5nsson", "given": "Emeli", "initials": "E"}, {"family": "Viklund Kamienny", "given": "Josefin", "initials": "J"}, {"family": "\u00d6stberg", "given": "Erland", "initials": "E"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Health Sci Rep", "issn": "2398-8835", "volume": "4", "issue": "4", "pages": "e446", "issn-l": null}, "abstract": "Most published reports of COVID-19 Intensive Care Unit (ICU) patients are from large tertiary hospitals and often present short-term or incomplete outcome data. There are reports indicating that ICUs with fewer beds are associated with higher mortality. This study aimed to investigate the definitive outcome and patient characteristics of the complete first wave of COVID-19 patients admitted to ICU in a secondary hospital.\n\nIn this prospective observational study, all patients with respiratory failure and a positive SARS-CoV-2 test admitted to V\u00e4ster\u00e5s Hospital ICU between 24 March and July 22, 2020 were included. The primary outcome was defined as 90-day mortality. Secondary outcomes included ICU length of stay, hospital length of stay, number of days with invasive ventilation, need for vasopressors/inotropes, and use of renal replacement therapy.\n\nFifty-three patients were included. Median age (range) was 59 (33-76) and 74% were men. Obesity and hypertension were the most common comorbidities and 45% of the patients were born outside Europe. Ninety-day mortality was 30%. Median ICU length of stay (interquartile range) was 14 (5-24) days and the duration of invasive mechanical ventilation 16 (12-26) days. No patients received dialysis at 90-day follow-up.\n\nIn this cohort of COVID-19 patients treated in a secondary hospital ICU, mortality rates were low compared to early studies from China, Italy, and the United States, but similar to other government-funded hospitals in Scandinavia. A preparatory reorganization enabled an increase in ICU capacity, hence avoiding an overwhelmed intensive care organization.", "doi": "10.1002/hsr2.446", "pmid": "34938894", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "HSR2446"}, {"db": "pmc", "key": "PMC8670731"}], "notes": [], "created": "2022-01-03T15:34:46.050Z", "modified": "2022-01-03T15:34:46.133Z"}, {"entity": "publication", "iuid": "34c0583ae1ea4e0c83bb5bac2f979093", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/34c0583ae1ea4e0c83bb5bac2f979093.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/34c0583ae1ea4e0c83bb5bac2f979093"}}, "title": "COVID-19 trends and severity among symptomatic children aged 0-17 years in 10 European Union countries, 3 August 2020 to 3 October 2021.", "authors": [{"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Dave", "given": "Nishi", "initials": "N"}, {"family": "Pharris", "given": "Anastasia", "initials": "A"}, {"family": "Spiteri", "given": "Gianfranco", "initials": "G"}, {"family": "Deogan", "given": "Charlotte", "initials": "C"}, {"family": "Suk", "given": "Jonathan E", "initials": "JE"}, {"family": "Study group members", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "50", "issn-l": null}, "abstract": "We estimated risks of severe outcomes in 820,404 symptomatic paediatric COVID-19 cases reported by 10 European Union countries between August 2020 and October 2021. Case and hospitalisation rates rose as transmission increased but severe outcomes were rare: 9,611 (1.2%) were hospitalised, 640 (0.08%) required intensive care and 84 (0.01%) died. Despite increased individual risk (adjusted odds ratio hospitalisation: 7.3; 95% confidence interval: 3.3-16.2; intensive care: 8.7; 6.2-12.3) in cases with comorbidities, most (83.7%) hospitalised children had no comorbidity.", "doi": "10.2807/1560-7917.ES.2021.26.50.2101098", "pmid": "34915968", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T17:44:33.895Z", "modified": "2021-12-18T17:44:33.907Z"}, {"entity": "publication", "iuid": "09c78ca7f2f44a6f8173de8e305a5ff5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/09c78ca7f2f44a6f8173de8e305a5ff5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/09c78ca7f2f44a6f8173de8e305a5ff5"}}, "title": "COVID-19 is Associated with an Acquired Factor XIII Deficiency.", "authors": [{"family": "von Meijenfeldt", "given": "Fien A", "initials": "FA"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Adelmeijer", "given": "Jelle", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Thalin", "given": "Charlotte", "initials": "C"}, {"family": "Lisman", "given": "Ton", "initials": "T"}], "type": "letter", "published": "2021-12-00", "journal": {"title": "Thromb Haemost", "issn": "2567-689X", "issn-l": "0340-6245", "volume": "121", "issue": "12", "pages": "1668-1669"}, "abstract": "No Abstract.", "doi": "10.1055/a-1450-8414", "pmid": "33742434", "labels": {"Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-22T10:28:03.488Z", "modified": "2022-02-06T17:15:14.074Z"}, {"entity": "publication", "iuid": "ac5fb4e2b68f4c5b8ee3a19341e6f046", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac5fb4e2b68f4c5b8ee3a19341e6f046.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac5fb4e2b68f4c5b8ee3a19341e6f046"}}, "title": "Asthma Diagnosis without Aerosol-Generating Procedures (Spirometry): Evidence for and Beyond the COVID-19 Pandemic", "authors": [{"family": "Kankaanranta", "given": "Hannu", "initials": "H"}, {"family": "Lehtim\u00e4ki", "given": "Lauri", "initials": "L"}, {"family": "Tuomisto", "given": "Leena E", "initials": "LE"}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "The Journal of Allergy and Clinical Immunology: In Practice", "issn": "2213-2198", "volume": "9", "issue": "12", "pages": "4252-4253", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jaip.2021.09.036", "pmid": null, "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:45:57.547Z", "modified": "2021-12-12T06:45:57.570Z"}, {"entity": "publication", "iuid": "460adc71009e4637b23139398f8c251a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/460adc71009e4637b23139398f8c251a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/460adc71009e4637b23139398f8c251a"}}, "title": "Appendicitis as a possible safety signal for the COVID-19 vaccines.", "authors": [{"family": "Mitchell", "given": "Joseph", "initials": "J"}, {"family": "Yue", "given": "Qun-Ying", "initials": "QY"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Vaccine X", "issn": "2590-1362", "volume": "9", "pages": "100122", "issn-l": null}, "abstract": "This study reviewed cases of appendicitis following administration of COVID-19 vaccines reported to VigiBase, the WHO database of individual case safety reports (ICSRs). Three hundred fifty-eight cases were identified, and disproportionate reporting was noted, with 329 calculated expected cases. Upon review, 24 ICSRs were excluded, so 334 unique ICSRs underwent clinical review from 19 countries. Forty-eight percent of ICSRs reported imaging and 69% noted surgical intervention. The cases were clinically coherent, with an apparent increase in reporting in the four days post-vaccination and a possible dose-response relationship. Appendicitis has been suggested as an adverse event of special interest post-vaccination against COVID-19 after a numerical increase in the vaccine arm of a clinical trial. The case series may be affected by differences in global patterns of reporting, and it is not possible to prove nor disprove causality from this case series. Global longitudinal studies are required to clarify any possible relationship.", "doi": "10.1016/j.jvacx.2021.100122", "pmid": "34746743", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2590-1362(21)00039-5"}, {"db": "pmc", "key": "PMC8565092"}], "notes": [], "created": "2021-11-26T15:34:13.902Z", "modified": "2021-11-26T15:34:26.952Z"}, {"entity": "publication", "iuid": "f7fbe5dff8494271a1aacb6195cf6751", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7fbe5dff8494271a1aacb6195cf6751.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7fbe5dff8494271a1aacb6195cf6751"}}, "title": "Angiotensin-Converting Enzyme 2 (SARS-CoV-2 receptor) expression in human skeletal muscle.", "authors": [{"family": "Perez-Valera", "given": "Mario", "initials": "M", "orcid": "0000-0002-8332-729X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35803b8f85964ce29760fbfad3aa06ac.json"}}, {"family": "Martinez-Canton", "given": "Miriam", "initials": "M", "orcid": "0000-0002-2925-3429", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77d454baf0894523ba5bc199eab7f95a.json"}}, {"family": "Gallego-Selles", "given": "Angel", "initials": "A", "orcid": "0000-0002-8068-9586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70d49ae713f2483fa618b92fbf1588d1.json"}}, {"family": "Galv\u00e1n-Alvarez", "given": "Victor", "initials": "V", "orcid": "0000-0002-1272-3471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f1c4f6e96b34be0a806da80c295efec.json"}}, {"family": "Gelabert-Rebato", "given": "Miriam", "initials": "M", "orcid": "0000-0002-8963-5568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0a3ce72669b4327b37c5a50bfc4e063.json"}}, {"family": "Morales-Alamo", "given": "David", "initials": "D", "orcid": "0000-0001-8463-397X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b9030289cfc412eb3ad0520a4f415fb.json"}}, {"family": "Santana", "given": "Alfredo", "initials": "A"}, {"family": "Martin-Rodriguez", "given": "Saul", "initials": "S", "orcid": "0000-0003-2423-5309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b26c4d0d7634deaa6a8869f40782e01.json"}}, {"family": "Ponce-Gonzalez", "given": "Jesus Gustavo", "initials": "JG", "orcid": "0000-0002-5982-7761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a276f5133dcc4bebb7bfae3939dd8f1b.json"}}, {"family": "Larsen", "given": "Steen", "initials": "S", "orcid": "0000-0002-5170-4337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c7e2c4f43b74b5ea6a52ec74ebb67ac.json"}}, {"family": "Losa-Reyna", "given": "Jose", "initials": "J", "orcid": "0000-0001-9545-5654", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/811b803c1ee749868f4b8ef94c82ded2.json"}}, {"family": "Perez-Suarez", "given": "Ismael", "initials": "I", "orcid": "0000-0002-7969-0061", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1ee30dc71c947028d55aecb45de60f3.json"}}, {"family": "Dorado", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-6616-6810", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db7e83e02066409988f34726d87735c5.json"}}, {"family": "Curtelin", "given": "David", "initials": "D", "orcid": "0000-0001-6462-382X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b9aecb9e275413a93fb0fc49b9198e6.json"}}, {"family": "Gonzalez-Henriquez", "given": "Juan Jose", "initials": "JJ", "orcid": "0000-0002-0622-5580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f66fd2bee3cd4391b23f6cba17aa7af3.json"}}, {"family": "Boushel", "given": "Robert", "initials": "R"}, {"family": "Hallen", "given": "Jostein", "initials": "J", "orcid": "0000-0002-6646-0734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8ad3bb0c71742dd95d6c584dc484254.json"}}, {"family": "de Pablos Velasco", "given": "Pedro", "initials": "P", "orcid": "0000-0002-9190-2581", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/951391585db9407bb6e42de7edb31c54.json"}}, {"family": "Freixinet-Gilart", "given": "Jorge", "initials": "J"}, {"family": "Holmberg", "given": "Hans-Christer", "initials": "HC", "orcid": "0000-0002-3814-6246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6325cd0a9474be49df847f6677f96bb.json"}}, {"family": "Helge", "given": "Jorn W", "initials": "JW", "orcid": "0000-0001-9724-5423", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0080b3aa65ce4d879c8c9c10e68b8d80.json"}}, {"family": "Martin-Rincon", "given": "Marcos", "initials": "M", "orcid": "0000-0002-3685-2331", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a26c0e8c2de4c07af458b07036369b4.json"}}, {"family": "Calbet", "given": "Jose A L", "initials": "JAL", "orcid": "0000-0002-9215-6234", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef57535cde26435ab75c47827f26bc48.json"}}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Scand J Med Sci Sports", "issn": "1600-0838", "issn-l": null, "volume": "31", "issue": "12", "pages": "2249-2258"}, "abstract": "The study aimed to determine the levels of skeletal muscle angiotensin-converting enzyme 2 (ACE2, the SARS-CoV-2 receptor) protein expression in men and women and assess whether ACE2 expression in skeletal muscle is associated with cardiorespiratory fitness and adiposity. The level of ACE2 in vastus lateralis muscle biopsies collected in previous studies from 170 men (age: 19-65 years, weight: 56-137 kg, BMI: 23-44) and 69 women (age: 18-55 years, weight: 41-126 kg, BMI: 22-39) was analyzed in duplicate by western blot. VO2 max was determined by ergospirometry and body composition by DXA. ACE2 protein expression was 1.8-fold higher in women than men (p = 0.001, n = 239). This sex difference disappeared after accounting for the percentage of body fat (fat %), VO2 max per kg of legs lean mass (VO2 max-LLM) and age (p = 0.47). Multiple regression analysis showed that the fat % (\u03b2 = 0.47) is the main predictor of the variability in ACE2 protein expression in skeletal muscle, explaining 5.2% of the variance. VO2 max-LLM had also predictive value (\u03b2 = 0.09). There was a significant fat % by VO2 max-LLM interaction, such that for subjects with low fat %, VO2 max-LLM was positively associated with ACE2 expression while as fat % increased the slope of the positive association between VO2 max-LLM and ACE2 was reduced. In conclusion, women express higher amounts of ACE2 in their skeletal muscles than men. This sexual dimorphism is mainly explained by sex differences in fat % and cardiorespiratory fitness. The percentage of body fat is the main predictor of the variability in ACE2 protein expression in human skeletal muscle.", "doi": "10.1111/sms.14061", "pmid": "34551157", "labels": {"Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8662278"}], "notes": [], "created": "2021-10-27T05:14:42.763Z", "modified": "2023-06-19T14:55:14.813Z"}, {"entity": "publication", "iuid": "efe78cba12754f37bbd373087552168b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/efe78cba12754f37bbd373087552168b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/efe78cba12754f37bbd373087552168b"}}, "title": "Alcohol consumption during the COVID-19 pandemic in Europe: a large-scale cross-sectional study in 21 countries.", "authors": [{"family": "Kilian", "given": "Carolin", "initials": "C", "orcid": "0000-0001-5913-6488", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed0409bb90b346cd9001bebb46bdcf87.json"}}, {"family": "Rehm", "given": "J\u00fcrgen", "initials": "J", "orcid": "0000-0001-5665-0385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83f5b8ddf5844eb6a1118d8ec4c4dca2.json"}}, {"family": "Allebeck", "given": "Peter", "initials": "P", "orcid": "0000-0002-2778-6467", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de9f0e1c3e4d402b93e61ad1c5a771fb.json"}}, {"family": "Braddick", "given": "Fleur", "initials": "F", "orcid": "0000-0001-6755-4567", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e9df2867269470ab43dd6802b5abb49.json"}}, {"family": "Gual", "given": "Antoni", "initials": "A", "orcid": "0000-0002-7130-981X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a9b53e2b8644056920e73b5b1d014d9.json"}}, {"family": "Bart\u00e1k", "given": "Miroslav", "initials": "M", "orcid": "0000-0002-7265-6514", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77e98268e4ef42f6a5a036b75d6a1c56.json"}}, {"family": "Bloomfield", "given": "Kim", "initials": "K", "orcid": "0000-0002-9740-126X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/17159b4979b74d4b81543e53c1e339ef.json"}}, {"family": "Gil", "given": "Artyom", "initials": "A", "orcid": "0000-0002-0548-5380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a39dedff1af2460a9053e78804085087.json"}}, {"family": "Neufeld", "given": "Maria", "initials": "M", "orcid": "0000-0001-6364-3765", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/641c0a90ba5c41ab904f9d1b8212b387.json"}}, {"family": "O'Donnell", "given": "Amy", "initials": "A", "orcid": "0000-0003-4071-9434", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ae93b46570e4fe092eb0dde1bf3edae.json"}}, {"family": "Petru\u017eelka", "given": "Benjamin", "initials": "B", "orcid": "0000-0003-0318-3589", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/135b991aff2a486cb76a4f362d85b5e6.json"}}, {"family": "Rogalewicz", "given": "Vladimir", "initials": "V", "orcid": "0000-0001-5432-4148", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/904dc3953e4e42d4ac5f317f7b3c5b36.json"}}, {"family": "Schulte", "given": "Bernd", "initials": "B", "orcid": "0000-0003-1139-030X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79c126298bdf42518d5d0384a7e1ec42.json"}}, {"family": "Manthey", "given": "Jakob", "initials": "J", "orcid": "0000-0003-1231-3760", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5e779db5bf14c38aad0f3a964b7d9bd.json"}}, {"family": "European Study Group on Alcohol Use and COVID-19", "given": "", "initials": ""}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Addiction", "issn": "1360-0443", "issn-l": null, "volume": "116", "issue": "12", "pages": "3369-3380"}, "abstract": "To investigate changes in alcohol consumption during the first months of the COVID-19 pandemic in Europe as well as its associations with income and experiences of distress related to the pandemic.\n\nCross-sectional on-line survey conducted between 24 April and 22 July 2020.\n\nTwenty-one European countries.\n\nA total of 31 964 adults reporting past-year drinking.\n\nChanges in alcohol consumption were measured by asking respondents about changes over the previous month in their drinking frequency, the quantity they consumed and incidence of heavy episodic drinking events. Individual indicators were combined into an aggregated consumption-change score and scaled to a possible range of -1 to +1. Using this score as the outcome, multi-level linear regressions tested changes in overall drinking, taking into account sampling weights and baseline alcohol consumption [Alcohol Use Disorder Identification Test (AUDIT-C)] and country of residence serving as random intercept. Similar models were conducted for each single consumption-change indicator.\n\nThe aggregated consumption-change score indicated an average decrease in alcohol consumption of -0.14 [95% confidence interval (CI) = -0.18, -0.10]. Statistically significant decreases in consumption were found in all countries, except Ireland (-0.08, 95% CI = -0.17, 0.01) and the United Kingdom (+0.10, 95% CI = 0.03, 0.17). Decreases in drinking were mainly driven by a reduced frequency of heavy episodic drinking events (-0.17, 95% CI = -0.20, -0.14). Declines in consumption were less marked among those with low- or average incomes and those experiencing distress.\n\nOn average, alcohol consumption appears to have declined during the first months of the COVID-19 pandemic in Europe. Both reduced availability of alcohol and increased distress may have affected consumption, although the former seems to have had a greater impact in terms of immediate effects.", "doi": "10.1111/add.15530", "pmid": "34109685", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-11T05:05:21.772Z", "modified": "2023-06-19T07:32:42.997Z"}, {"entity": "publication", "iuid": "196bb322291948ddb3242acd3929326f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/196bb322291948ddb3242acd3929326f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/196bb322291948ddb3242acd3929326f"}}, "title": "Acquired olfactory loss alters functional connectivity and morphology", "authors": [{"family": "Iravani", "given": "Behzad", "initials": "B"}, {"family": "Peter", "given": "Moa G", "initials": "MG"}, {"family": "Arshamian", "given": "Artin", "initials": "A"}, {"family": "Olsson", "given": "Mats J", "initials": "MJ"}, {"family": "Hummel", "given": "Thomas", "initials": "T"}, {"family": "Kitzler", "given": "Hagen H", "initials": "HH"}, {"family": "Lundstr\u00f6m", "given": "Johan N", "initials": "JN"}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": null}, "abstract": null, "doi": "10.1038/s41598-021-95968-7", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-15T15:48:22.155Z", "modified": "2022-07-06T06:58:18.400Z"}, {"entity": "publication", "iuid": "15f52e9d5ead4387aae6b6cd95392dae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15f52e9d5ead4387aae6b6cd95392dae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15f52e9d5ead4387aae6b6cd95392dae"}}, "title": "A population-based dataset concerning predictors of willingness to get a COVID-19 vaccine in Iran.", "authors": [{"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}, {"family": "Yahaghi", "given": "Rafat", "initials": "R"}, {"family": "Ahmadizade", "given": "Safie", "initials": "S"}, {"family": "Fotuhi", "given": "Razie", "initials": "R"}, {"family": "Taherkhani", "given": "Elham", "initials": "E"}, {"family": "Ranjbaran", "given": "Mehdi", "initials": "M"}, {"family": "Buchali", "given": "Zeinab", "initials": "Z"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Data Brief", "issn": "2352-3409", "issn-l": null, "volume": "39", "issue": null, "pages": "107459"}, "abstract": "The global issue of preventing the spread of COVID-19 is challenging. One of the most efficient ways to control the pandemic is to have a full coverage of COVID-19 vaccination. Therefore, this paper collected survey data to understand the intention and willingness of COVID-19 vaccination uptake in Qazvin, Iran. With the use of a paper-and-pencil method and multistage stratified cluster sampling, research personnel approached and interviewed a representative sample of adults in Qazvin (n = 10843) between February 19 and April 9, 2021. The survey asked questions regarding sociodemographic information, fear of COVID-19, perceived COVID-19 infectability, perceived behavioral control over COVID-19 vaccination, subjective norm of COVID-19 vaccination, attitude towards COVID-19 vaccination, and intention to get COVID-19 vaccinated. The data collected from this survey were analyzed using descriptive statistics, which were carried out using the IBM SPSS version 17.0.", "doi": "10.1016/j.dib.2021.107459", "pmid": "34660863", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC8500683"}, {"db": "pii", "key": "S2352-3409(21)00741-1"}], "notes": [], "created": "2021-10-21T05:00:29.137Z", "modified": "2023-06-19T15:21:28.910Z"}, {"entity": "publication", "iuid": "5209cda5a4434416b9a275a6087f708e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5209cda5a4434416b9a275a6087f708e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5209cda5a4434416b9a275a6087f708e"}}, "title": "A global observational analysis to understand changes in air quality during exceptionally low anthropogenic emission conditions", "authors": [{"family": "Sokhi", "given": "Ranjeet S", "initials": "RS"}, {"family": "Singh", "given": "Vikas", "initials": "V"}, {"family": "Querol", "given": "Xavier", "initials": "X"}, {"family": "Finardi", "given": "Sandro", "initials": "S"}, {"family": "Targino", "given": "Admir Cr\u00e9so", "initials": "AC"}, {"family": "Andrade", "given": "Maria de Fatima", "initials": "MdF"}, {"family": "Pavlovic", "given": "Radenko", "initials": "R"}, {"family": "Garland", "given": "Rebecca M", "initials": "RM"}, {"family": "Massagu\u00e9", "given": "Jordi", "initials": "J"}, {"family": "Kong", "given": "Shaofei", "initials": "S"}, {"family": "Baklanov", "given": "Alexander", "initials": "A"}, {"family": "Ren", "given": "Lu", "initials": "L"}, {"family": "Tarasova", "given": "Oksana", "initials": "O"}, {"family": "Carmichael", "given": "Greg", "initials": "G"}, {"family": "Peuch", "given": "Vincent Henri", "initials": "VH"}, {"family": "Anand", "given": "Vrinda", "initials": "V"}, {"family": "Arbilla", "given": "Graciela", "initials": "G"}, {"family": "Badali", "given": "Kaitlin", "initials": "K"}, {"family": "Beig", "given": "Gufran", "initials": "G"}, {"family": "Belalcazar", "given": "Luis Carlos", "initials": "LC"}, {"family": "Bolignano", "given": "Andrea", "initials": "A"}, {"family": "Brimblecombe", "given": "Peter", "initials": "P"}, {"family": "Camacho", "given": "Patricia", "initials": "P"}, {"family": "Casallas", "given": "Alejandro", "initials": "A"}, {"family": "Charland", "given": "Jean Pierre", "initials": "JP"}, {"family": "Choi", "given": "Jason", "initials": "J"}, {"family": "Chourdakis", "given": "Eleftherios", "initials": "E"}, {"family": "Coll", "given": "Isabelle", "initials": "I"}, {"family": "Collins", "given": "Marty", "initials": "M"}, {"family": "Cyrys", "given": "Josef", "initials": "J"}, {"family": "da Silva", "given": "Cleyton Martins", "initials": "CM"}, {"family": "Di Giosa", "given": "Alessandro Domenico", "initials": "AD"}, {"family": "Di Leo", "given": "Anna", "initials": "A"}, {"family": "Ferro", "given": "Camilo", "initials": "C"}, {"family": "Gavidia-Calderon", "given": "Mario", "initials": "M"}, {"family": "Gayen", "given": "Amiya", "initials": "A"}, {"family": "Ginzburg", "given": "Alexander", "initials": "A"}, {"family": "Godefroy", "given": "Fabrice", "initials": "F"}, {"family": "Gonzalez", "given": "Yuri Alexandra", "initials": "YA"}, {"family": "Guevara-Luna", "given": "Marco", "initials": "M"}, {"family": "Haque", "given": "Sk Mafizul", "initials": "SM"}, {"family": "Havenga", "given": "Henno", "initials": "H"}, {"family": "Herod", "given": "Dennis", "initials": "D"}, {"family": "H\u00f5rrak", "given": "Urmas", "initials": "U"}, {"family": "Hussein", "given": "Tareq", "initials": "T"}, {"family": "Ibarra", "given": "Sergio", "initials": "S"}, {"family": "Jaimes", "given": "Monica", "initials": "M"}, {"family": "Kaasik", "given": "Marko", "initials": "M"}, {"family": "Khaiwal", "given": "Ravindra", "initials": "R"}, {"family": "Kim", "given": "Jhoon", "initials": "J"}, {"family": "Kousa", "given": "Anu", "initials": "A"}, {"family": "Kukkonen", "given": "Jaakko", "initials": "J"}, {"family": "Kulmala", "given": "Markku", "initials": "M"}, {"family": "Kuula", "given": "Joel", "initials": "J"}, {"family": "La Violette", "given": "Nathalie", "initials": "N"}, {"family": "Lanzani", "given": "Guido", "initials": "G"}, {"family": "Liu", "given": "Xi", "initials": "X"}, {"family": "MacDougall", "given": "Stephanie", "initials": "S"}, {"family": "Manseau", "given": "Patrick M", "initials": "PM"}, {"family": "Marchegiani", "given": "Giada", "initials": "G"}, {"family": "McDonald", "given": "Brian", "initials": "B"}, {"family": "Mishra", "given": "Swasti Vardhan", "initials": "SV"}, {"family": "Molina", "given": "Luisa T", "initials": "LT"}, {"family": "Mooibroek", "given": "Dennis", "initials": "D"}, {"family": "Mor", "given": "Suman", "initials": "S"}, {"family": "Moussiopoulos", "given": "Nicolas", "initials": "N"}, {"family": "Murena", "given": "Fabio", "initials": "F"}, {"family": "Niemi", "given": "Jarkko V", "initials": "JV"}, {"family": "Noe", "given": "Steffen", "initials": "S"}, {"family": "Nogueira", "given": "Thiago", "initials": "T"}, {"family": "Norman", "given": "Michael", "initials": "M"}, {"family": "P\u00e9rez-Cama\u00f1o", "given": "Juan Luis", "initials": "JL"}, {"family": "Pet\u00e4j\u00e4", "given": "Tuukka", "initials": "T"}, {"family": "Piketh", "given": "Stuart", "initials": "S"}, {"family": "Rathod", "given": "Aditi", "initials": "A"}, {"family": "Reid", "given": "Ken", "initials": "K"}, {"family": "Retama", "given": "Armando", "initials": "A"}, {"family": "Rivera", "given": "Olivia", "initials": "O"}, {"family": "Rojas", "given": "N\u00e9stor Y", "initials": "NY"}, {"family": "Rojas-Quincho", "given": "Jhojan P", "initials": "JP"}, {"family": "San Jos\u00e9", "given": "Roberto", "initials": "R"}, {"family": "S\u00e1nchez", "given": "Od\u00f3n", "initials": "O"}, {"family": "Seguel", "given": "Rodrigo J", "initials": "RJ"}, {"family": "Sillanp\u00e4\u00e4", "given": "Salla", "initials": "S"}, {"family": "Su", "given": "Yushan", "initials": "Y"}, {"family": "Tapper", "given": "Nigel", "initials": "N"}, {"family": "Terrazas", "given": "Antonio", "initials": "A"}, {"family": "Timonen", "given": "Hilkka", "initials": "H"}, {"family": "Toscano", "given": "Domenico", "initials": "D"}, {"family": "Tsegas", "given": "George", "initials": "G"}, {"family": "Velders", "given": "Guus J M", "initials": "GJM"}, {"family": "Vlachokostas", "given": "Christos", "initials": "C"}, {"family": "von Schneidemesser", "given": "Erika", "initials": "E"}, {"family": "VPM", "given": "Rajasree", "initials": "R"}, {"family": "Yadav", "given": "Ravi", "initials": "R"}, {"family": "Zalakeviciute", "given": "Rasa", "initials": "R"}, {"family": "Zavala", "given": "Miguel", "initials": "M"}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "Environ Int", "issn": "0160-4120", "volume": "157", "pages": "106818", "issn-l": null}, "abstract": null, "doi": "10.1016/j.envint.2021.106818", "pmid": null, "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-27T09:40:05.202Z", "modified": "2021-08-27T09:40:05.218Z"}, {"entity": "publication", "iuid": "2d92617b4d3e42e2beca4d29d9785cba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d92617b4d3e42e2beca4d29d9785cba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d92617b4d3e42e2beca4d29d9785cba"}}, "title": "A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome: No Evidence of Benefit, Supported by Epidemiology and In Vitro Data", "authors": [{"family": "Wel\u00e9n", "given": "Karin", "initials": "K"}, {"family": "Rosendal", "given": "Ebba", "initials": "E"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Lenman", "given": "Annasara", "initials": "A"}, {"family": "Freyhult", "given": "Eva", "initials": "E"}, {"family": "Fonseca-Rodr\u00edguez", "given": "Osvaldo", "initials": "O"}, {"family": "Bremell", "given": "Daniel", "initials": "D"}, {"family": "Stranne", "given": "Johan", "initials": "J"}, {"family": "Balkhed", "given": "\u00c5se \u00d6stholm", "initials": "\u00c5\u00d6"}, {"family": "Niward", "given": "Katarina", "initials": "K"}, {"family": "Repo", "given": "Johanna", "initials": "J"}, {"family": "Robinsson", "given": "David", "initials": "D"}, {"family": "Henningsson", "given": "Anna J", "initials": "AJ"}, {"family": "Styrke", "given": "Johan", "initials": "J"}, {"family": "Angelin", "given": "Martin", "initials": "M"}, {"family": "Lindquist", "given": "Elisabeth", "initials": "E"}, {"family": "Allard", "given": "Annika", "initials": "A"}, {"family": "Becker", "given": "Miriam", "initials": "M"}, {"family": "Rudolfsson", "given": "Stina", "initials": "S"}, {"family": "Buckland", "given": "Robert", "initials": "R"}, {"family": "Carlsson", "given": "Camilla Thellenberg", "initials": "CT"}, {"family": "Bjartell", "given": "Anders", "initials": "A"}, {"family": "Nilsson", "given": "Anna C", "initials": "AC"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Connolly", "given": "Anne Marie Fors", "initials": "AMF"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "Josefsson", "given": "Andreas", "initials": "A"}], "type": "journal-article", "published": "2021-12-00", "journal": {"title": "European Urology", "issn": "0302-2838", "issn-l": null}, "abstract": null, "doi": "10.1016/j.eururo.2021.12.013", "pmid": "34980495", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T14:42:26.854Z", "modified": "2022-01-10T15:43:27.765Z"}, {"entity": "publication", "iuid": "d14b85b93cb844bcbed101295548421f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d14b85b93cb844bcbed101295548421f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d14b85b93cb844bcbed101295548421f"}}, "title": "Unsuccessful and Successful Clinical Trials in Acute Respiratory Distress Syndrome: Addressing Physiology-Based Gaps.", "authors": [{"family": "Villar", "given": "Jes\u00fas", "initials": "J"}, {"family": "Ferrando", "given": "Carlos", "initials": "C"}, {"family": "Tusman", "given": "Gerardo", "initials": "G"}, {"family": "Berra", "given": "Lorenzo", "initials": "L"}, {"family": "Rodr\u00edguez-Su\u00e1rez", "given": "Pedro", "initials": "P"}, {"family": "Su\u00e1rez-Sipmann", "given": "Fernando", "initials": "F"}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "Front Physiol", "issn": "1664-042X", "volume": "12", "pages": "774025", "issn-l": null}, "abstract": "The acute respiratory distress syndrome (ARDS) is a severe form of acute hypoxemic respiratory failure caused by an insult to the alveolar-capillary membrane, resulting in a marked reduction of aerated alveoli, increased vascular permeability and subsequent interstitial and alveolar pulmonary edema, reduced lung compliance, increase of physiological dead space, and hypoxemia. Most ARDS patients improve their systemic oxygenation, as assessed by the ratio between arterial partial pressure of oxygen and inspired oxygen fraction, with conventional intensive care and the application of moderate-to-high levels of positive end-expiratory pressure. However, in some patients hypoxemia persisted because the lungs are markedly injured, remaining unresponsive to increasing the inspiratory fraction of oxygen and positive end-expiratory pressure. For decades, mechanical ventilation was the only standard support technique to provide acceptable oxygenation and carbon dioxide removal. Mechanical ventilation provides time for the specific therapy to reverse the disease-causing lung injury and for the recovery of the respiratory function. The adverse effects of mechanical ventilation are direct consequences of the changes in pulmonary airway pressures and intrathoracic volume changes induced by the repetitive mechanical cycles in a diseased lung. In this article, we review 14 major successful and unsuccessful randomized controlled trials conducted in patients with ARDS on a series of techniques to improve oxygenation and ventilation published since 2010. Those trials tested the effects of adjunctive therapies (neuromuscular blocking agents, prone positioning), methods for selecting the optimum positive end-expiratory pressure (after recruitment maneuvers, or guided by esophageal pressure), high-frequency oscillatory ventilation, extracorporeal oxygenation, and pharmacologic immune modulators of the pulmonary and systemic inflammatory responses in patients affected by ARDS. We will briefly comment physiology-based gaps of negative trials and highlight the possible needs to address in future clinical trials in ARDS.", "doi": "10.3389/fphys.2021.774025", "pmid": "34916959", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8669801"}], "notes": [], "created": "2021-12-18T17:42:17.076Z", "modified": "2021-12-18T17:42:17.088Z"}, {"entity": "publication", "iuid": "acb0b2a3a77b41a6b28110c03160a6b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/acb0b2a3a77b41a6b28110c03160a6b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/acb0b2a3a77b41a6b28110c03160a6b4"}}, "title": "The effects of different travel modes and travel destinations on COVID-19 transmission in global cities.", "authors": [{"family": "Zhu", "given": "Rui", "initials": "R"}, {"family": "Anselin", "given": "Luc", "initials": "L"}, {"family": "Batty", "given": "Michael", "initials": "M"}, {"family": "Kwan", "given": "Mei-Po", "initials": "MP"}, {"family": "Chen", "given": "Min", "initials": "M"}, {"family": "Luo", "given": "Wei", "initials": "W"}, {"family": "Cheng", "given": "Tao", "initials": "T"}, {"family": "Lim", "given": "Che Kang", "initials": "CK"}, {"family": "Santi", "given": "Paolo", "initials": "P"}, {"family": "Cheng", "given": "Cheng", "initials": "C"}, {"family": "Gu", "given": "Qiushi", "initials": "Q"}, {"family": "Wong", "given": "Man Sing", "initials": "MS"}, {"family": "Zhang", "given": "Kai", "initials": "K"}, {"family": "L\u00fc", "given": "Guonian", "initials": "G"}, {"family": "Ratti", "given": "Carlo", "initials": "C"}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "Sci Bull (Beijing)", "issn": "2095-9273", "issn-l": null}, "abstract": null, "doi": "10.1016/j.scib.2021.11.023", "pmid": "34868708", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2095-9273(21)00731-3"}, {"db": "pmc", "key": "PMC8631046"}], "notes": [], "created": "2021-12-12T07:08:23.462Z", "modified": "2021-12-12T07:09:00.122Z"}, {"entity": "publication", "iuid": "df7653ff47fd45239730fb0c6777cc43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/df7653ff47fd45239730fb0c6777cc43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/df7653ff47fd45239730fb0c6777cc43"}}, "title": "Epidemiology and factors associated with COVID-19 outbreak-related deaths in patients admitted to medical centers of Mazandaran University of Medical Sciences.", "authors": [{"family": "Khankeh", "given": "Hamidreza", "initials": "H"}, {"family": "Farrokhi", "given": "Mehrdad", "initials": "M"}, {"family": "Ghadicolaei", "given": "Hassan Talebi", "initials": "HT"}, {"family": "Mazhin", "given": "Sadegh Ahmadi", "initials": "SA"}, {"family": "Roudini", "given": "Juliet", "initials": "J"}, {"family": "Mohsenzadeh", "given": "Yazdan", "initials": "Y"}, {"family": "Hadinejad", "given": "Zoya", "initials": "Z"}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "J Educ Health Promot", "issn": "2277-9531", "volume": "10", "pages": "426", "issn-l": null}, "abstract": "The first case of COVID-19 was reported in Iran on February 19, 2020, in Qom. Since Mazandaran is one of the high-risk provinces with many patients and deaths, this study was conducted to investigate the epidemiological characteristics of COVID-19-related deaths in Mazandaran.\n\nIn this descriptive study, demographic information and clinical findings in patients who died following COVID-19 in the medical centers of Mazandaran University of Medical Sciences from February 8, 2020, to October 10, 2020, were extracted. Data were analyzed by using SPSS 21. Logistic regression was used to compare the data. P < 0.05 was considered as the significance level.\n\nOut of a total of 34,039 patients admitted during the 8 months, 2907 patients died. Of these, 1529 (52%) were male, and the rest were female. In terms of age, 10 cases in the age group of fewer than 15 years, 229 cases in the age group of 15-44 years, 864 patients in the age group of 45-64 years, and 1793 people in the age group of 65 years and over died. 2206 people (more than 75%) by personal visit referred to medical centers. The mortality rate was more than 8 cases per 100 hospitalized patients. Men were 16% more likely to die from COVID-19 than women.\n\nOlder adults over 65 have the highest incidence and death rate due to this disease. The incidence rate was higher in women, and the death rate was higher in men, which differs from the national pattern.", "doi": "10.4103/jehp.jehp_192_21", "pmid": "35071632", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "JEHP-10-426"}, {"db": "pmc", "key": "PMC8719545"}], "notes": [], "created": "2022-01-26T10:16:48.419Z", "modified": "2022-01-26T10:16:48.452Z"}, {"entity": "publication", "iuid": "d4d0b48d3aee47a6b6f277156b63cfc3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4d0b48d3aee47a6b6f277156b63cfc3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4d0b48d3aee47a6b6f277156b63cfc3"}}, "title": "Effects of immunosuppressive drugs on COVID-19 severity in patients with autoimmune hepatitis.", "authors": [{"family": "Efe", "given": "Cumali", "initials": "C", "orcid": "0000-0001-6593-5702", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cd621ab96e04e678b0188c48d54b90a.json"}}, {"family": "Lammert", "given": "Craig", "initials": "C", "orcid": "0000-0003-3809-640X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3c2fe9871074a22a95a55375edc3b62.json"}}, {"family": "Ta\u015f\u00e7\u0131lar", "given": "Koray", "initials": "K"}, {"family": "Dhanasekaran", "given": "Renumathy", "initials": "R", "orcid": "0000-0001-8819-7511", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/144c4ddb38ed4c99adca4b6ae626a533.json"}}, {"family": "Ebik", "given": "Berat", "initials": "B"}, {"family": "Higuera-de la Tijera", "given": "Fatima", "initials": "F"}, {"family": "Cal\u0131\u015fkan", "given": "Ali R", "initials": "AR"}, {"family": "Peralta", "given": "Mirta", "initials": "M"}, {"family": "Gerussi", "given": "Alessio", "initials": "A"}, {"family": "Massoumi", "given": "Hatef", "initials": "H"}, {"family": "Catana", "given": "Andreea M", "initials": "AM"}, {"family": "Purnak", "given": "Tugrul", "initials": "T"}, {"family": "Rigamonti", "given": "Cristina", "initials": "C"}, {"family": "Aldana", "given": "Andres J G", "initials": "AJG"}, {"family": "Khakoo", "given": "Nidah", "initials": "N"}, {"family": "Nazal", "given": "Leyla", "initials": "L"}, {"family": "Frager", "given": "Shalom", "initials": "S"}, {"family": "Demir", "given": "Nurhan", "initials": "N"}, {"family": "Irak", "given": "Kader", "initials": "K"}, {"family": "Meleko\u011flu-Ellik", "given": "Zeynep", "initials": "Z"}, {"family": "Kacmaz", "given": "H\u00fcseyin", "initials": "H"}, {"family": "Balaban", "given": "Yasemin", "initials": "Y"}, {"family": "Atay", "given": "Kadri", "initials": "K"}, {"family": "Eren", "given": "Fatih", "initials": "F"}, {"family": "Alvares-da-Silva", "given": "Mario R", "initials": "MR"}, {"family": "Cristoferi", "given": "Laura", "initials": "L"}, {"family": "Urzua", "given": "\u00c1lvaro", "initials": "\u00c1"}, {"family": "E\u015fkazan", "given": "Tu\u011f\u00e7e", "initials": "T"}, {"family": "Magro", "given": "Bianca", "initials": "B"}, {"family": "Snijders", "given": "Romee", "initials": "R"}, {"family": "Barut\u00e7u", "given": "Sezgin", "initials": "S"}, {"family": "Lytvyak", "given": "Ellina", "initials": "E"}, {"family": "Zazueta", "given": "Godolfino M", "initials": "GM"}, {"family": "Demirezer-Bolat", "given": "Aylin", "initials": "A"}, {"family": "Ayd\u0131n", "given": "Mesut", "initials": "M"}, {"family": "Heurgue-Berlot", "given": "Alexandra", "initials": "A"}, {"family": "De Martin", "given": "Eleonora", "initials": "E"}, {"family": "Ekin", "given": "Naz\u0131m", "initials": "N"}, {"family": "Y\u0131ld\u0131r\u0131m", "given": "S\u00fcmeyra", "initials": "S"}, {"family": "Yavuz", "given": "Ahmet", "initials": "A"}, {"family": "B\u0131y\u0131k", "given": "Murat", "initials": "M"}, {"family": "Narro", "given": "Graciela C", "initials": "GC"}, {"family": "K\u0131y\u0131c\u0131", "given": "Murat", "initials": "M"}, {"family": "Aky\u0131ld\u0131z", "given": "Murat", "initials": "M"}, {"family": "Kahramano\u011flu-Aksoy", "given": "Evrim", "initials": "E"}, {"family": "Vincent", "given": "Maria", "initials": "M"}, {"family": "Carr", "given": "Rotonya M", "initials": "RM"}, {"family": "G\u00fcn\u015far", "given": "Fulya", "initials": "F"}, {"family": "Reyes", "given": "Eira C", "initials": "EC"}, {"family": "Harputluo\u011flu", "given": "Murat", "initials": "M"}, {"family": "Aloman", "given": "Costica", "initials": "C"}, {"family": "Gatselis", "given": "Nikolaos K", "initials": "NK"}, {"family": "\u00dcst\u00fcnda\u011f", "given": "Y\u00fccel", "initials": "Y"}, {"family": "Brahm", "given": "Javier", "initials": "J"}, {"family": "Vargas", "given": "Nataly C E", "initials": "NCE"}, {"family": "G\u00fczelbulut", "given": "Fatih", "initials": "F", "orcid": "0000-0003-4889-208X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b376f922688245a6a37c9d9db086c5c0.json"}}, {"family": "Garcia", "given": "Sandro R", "initials": "SR"}, {"family": "Aguirre", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-6291-2545", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e597179292724adeafa651fb99c26573.json"}}, {"family": "Anders", "given": "Margarita", "initials": "M"}, {"family": "Ratusnu", "given": "Natalia", "initials": "N"}, {"family": "Hatemi", "given": "Ibrahim", "initials": "I"}, {"family": "Mendizabal", "given": "Manuel", "initials": "M"}, {"family": "Floreani", "given": "Annarosa", "initials": "A"}, {"family": "Fagiuoli", "given": "Stefano", "initials": "S"}, {"family": "Silva", "given": "Marcelo", "initials": "M"}, {"family": "Idilman", "given": "Ramazan", "initials": "R"}, {"family": "Satapathy", "given": "Sanjaya K", "initials": "SK", "orcid": "0000-0003-0153-2829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46079042944846e2a2ab5791ffd3ac85.json"}}, {"family": "Silveira", "given": "Marina", "initials": "M"}, {"family": "Drenth", "given": "Joost P H", "initials": "JPH", "orcid": "0000-0001-8027-3073", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7b6dc5554ee4911b90e100f311d69ca.json"}}, {"family": "Dalekos", "given": "George N", "initials": "GN"}, {"family": "N Assis", "given": "David", "initials": "D"}, {"family": "Bj\u00f6rnsson", "given": "Einar", "initials": "E", "orcid": "0000-0002-8392-0632", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d61afcd69274877ab6be778e0b191f6.json"}}, {"family": "Boyer", "given": "James L", "initials": "JL"}, {"family": "Yoshida", "given": "Eric M", "initials": "EM"}, {"family": "Invernizzi", "given": "Pietro", "initials": "P", "orcid": "0000-0003-3262-1998", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2e4ae30eec648eea09a264143952d7e.json"}}, {"family": "Levy", "given": "Cynthia", "initials": "C", "orcid": "0000-0001-5498-6037", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15588be194364b57b71d2f15526456c7.json"}}, {"family": "Montano-Loza", "given": "Aldo J", "initials": "AJ", "orcid": "0000-0002-2511-7980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a64b4bf7fe0848c6bde4f61b031d8900.json"}}, {"family": "Schiano", "given": "Thomas D", "initials": "TD"}, {"family": "Ridruejo", "given": "Ezequiel", "initials": "E"}, {"family": "Wahlin", "given": "Staffan", "initials": "S"}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "Liver Int", "issn": "1478-3231", "issn-l": null}, "abstract": "We investigated associations between baseline use of immunosuppressive drugs and severity of Coronavirus Disease 2019 (COVID-19) in autoimmune hepatitis (AIH).\n\nData of AIH patients with laboratory confirmed COVID-19 were retrospectively collected from 15 countries. The outcomes of AIH patients who were on immunosuppression at the time of COVID-19 were compared to patients who were not on AIH medication. The clinical courses of COVID-19 were classified as (i)-no hospitalization, (ii)-hospitalization without oxygen supplementation, (iii)-hospitalization with oxygen supplementation by nasal cannula or mask, (iv)-intensive care unit (ICU) admission with non-invasive mechanical ventilation, (v)-ICU admission with invasive mechanical ventilation or (vi)-death and analysed using ordinal logistic regression.\n\nWe included 254 AIH patients (79.5%, female) with a median age of 50 (range, 17-85) years. At the onset of COVID-19, 234 patients (92.1%) were on treatment with glucocorticoids (n = 156), thiopurines (n = 151), mycophenolate mofetil (n = 22) or tacrolimus (n = 16), alone or in combinations. Overall, 94 (37%) patients were hospitalized and 18 (7.1%) patients died. Use of systemic glucocorticoids (adjusted odds ratio [aOR] 4.73, 95% CI 1.12-25.89) and thiopurines (aOR 4.78, 95% CI 1.33-23.50) for AIH was associated with worse COVID-19 severity, after adjusting for age-sex, comorbidities and presence of cirrhosis. Baseline treatment with mycophenolate mofetil (aOR 3.56, 95% CI 0.76-20.56) and tacrolimus (aOR 4.09, 95% CI 0.69-27.00) were also associated with more severe COVID-19 courses in a smaller subset of treated patients.\n\nBaseline treatment with systemic glucocorticoids or thiopurines prior to the onset of COVID-19 was significantly associated with COVID-19 severity in patients with AIH.", "doi": "10.1111/liv.15121", "pmid": "34846800", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T18:10:28.983Z", "modified": "2021-12-18T18:10:29.323Z"}, {"entity": "publication", "iuid": "1ff9c3f0e55f4ec5bac4e50071aa7305", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ff9c3f0e55f4ec5bac4e50071aa7305.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ff9c3f0e55f4ec5bac4e50071aa7305"}}, "title": "Cohort study of the characteristics and outcomes in patients with COVID-19 and in-hospital cardiac arrest.", "authors": [{"family": "Holm", "given": "Astrid", "initials": "A", "orcid": "0000-0003-4226-7494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7dede94c48304ae09e2db9691584ab36.json"}}, {"family": "Jerkeman", "given": "Matilda", "initials": "M"}, {"family": "Sultanian", "given": "Pedram", "initials": "P", "orcid": "0000-0002-6941-6659", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/903a11645aaa4218bd36f1e51187783c.json"}}, {"family": "Lundgren", "given": "Peter", "initials": "P"}, {"family": "Ravn-Fischer", "given": "Annica", "initials": "A"}, {"family": "Israelsson", "given": "Johan", "initials": "J"}, {"family": "Giesecke", "given": "Jasna", "initials": "J"}, {"family": "Herlitz", "given": "Johan", "initials": "J"}, {"family": "Rawshani", "given": "Araz", "initials": "A", "orcid": "0000-0003-2066-3533", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ffcc83bb40a4a22aec7dffe6c890da0.json"}}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "11", "pages": "e054943", "issn-l": "2044-6055"}, "abstract": "We studied characteristics, survival, causes of cardiac arrest, conditions preceding cardiac arrest, predictors of survival and trends in the prevalence of COVID-19 among in-hospital cardiac arrest (IHCA) cases.\n\nRegistry-based observational study.\n\nWe studied all cases (\u226518 years of age) of IHCA receiving cardiopulmonary resuscitation in the Swedish Registry for Cardiopulmonary Resuscitation during 15 March 2020 to 31 December 2020. A total of 1613 patients were included and divided into the following groups: ongoing infection (COVID-19+; n=182), no infection (COVID-19-; n=1062) and unknown/not assessed (n=369).\n\nWe studied monthly trends in proportions of COVID-19 associated IHCAs, causes of IHCA in relation to COVID-19 status, clinical conditions preceding the cardiac arrest and predictors of survival.\n\nThe rate of COVID-19+ patients suffering an IHCA increased to 23% during the first pandemic wave (April), then abated to 3% in July, and then increased to 19% during the second wave (December). Among COVID-19+ cases, 43% had respiratory insufficiency or infection as the underlying cause of the cardiac arrest, compared with 18% among COVID-19- cases. The most common clinical sign preceding cardiac arrest was hypoxia (57%) among COVID-19+ cases. OR for 30-day survival for COVID-19+ cases was 0.50 (95% CI 0.33 to 0.76), compared with COVID-19- cases.\n\nDuring pandemic peaks, up to one-fourth of all IHCAs are complicated by COVID-19, and these patients have halved chance of survival, with women displaying the worst outcomes.", "doi": "10.1136/bmjopen-2021-054943", "pmid": "34848525", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-054943"}, {"db": "pmc", "key": "PMC8635887"}], "notes": [], "created": "2021-12-18T18:09:55.672Z", "modified": "2021-12-18T18:09:55.806Z"}, {"entity": "publication", "iuid": "3e5fbd3eafad422c9ff64235ae8e42eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3e5fbd3eafad422c9ff64235ae8e42eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3e5fbd3eafad422c9ff64235ae8e42eb"}}, "title": "Avoiding bias in self-controlled case series studies of coronavirus disease 2019.", "authors": [{"family": "Fonseca-Rodr\u00edguez", "given": "Osvaldo", "initials": "O"}, {"family": "Fors Connolly", "given": "Anne-Marie", "initials": "AM", "orcid": "0000-0001-9215-4047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff46cc7d9e374929a14350748727ba60.json"}}, {"family": "Katsoularis", "given": "Ioannis", "initials": "I"}, {"family": "Lindmark", "given": "Krister", "initials": "K"}, {"family": "Farrington", "given": "Paddy", "initials": "P", "orcid": "0000-0002-7148-2612", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/586b1e765406444d85c192ba61708ce0.json"}}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "Stat Med", "issn": "1097-0258", "issn-l": null, "volume": "40", "issue": "27", "pages": "6197-6208"}, "abstract": "Many studies, including self-controlled case series (SCCS) studies, are being undertaken to quantify the risks of complications following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). One such SCCS study, based on all COVID-19 cases arising in Sweden over an 8-month period, has shown that SARS-CoV-2 infection increases the risks of AMI and ischemic stroke. Some features of SARS-CoV-2 infection and COVID-19, present in this study and likely in others, complicate the analysis and may introduce bias. In the present paper we describe these features, and explore the biases they may generate. Motivated by data-based simulations, we propose methods to reduce or remove these biases.", "doi": "10.1002/sim.9179", "pmid": "34470078", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8661887"}], "notes": [], "created": "2021-09-06T06:17:45.140Z", "modified": "2023-06-19T14:47:13.405Z"}, {"entity": "publication", "iuid": "bd9c86c4cf594ec6a0e7a3155401ba54", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bd9c86c4cf594ec6a0e7a3155401ba54.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bd9c86c4cf594ec6a0e7a3155401ba54"}}, "title": "Application of Stem Cell-Derived Extracellular Vesicles as an Innovative Theranostics in Microbial Diseases.", "authors": [{"family": "Keshavarz Alikhani", "given": "Hani", "initials": "H"}, {"family": "Shokoohian", "given": "Bahare", "initials": "B"}, {"family": "Rezasoltani", "given": "Sama", "initials": "S"}, {"family": "Hossein-Khannazer", "given": "Nikoo", "initials": "N"}, {"family": "Yadegar", "given": "Abbas", "initials": "A"}, {"family": "Hassan", "given": "Moustapha", "initials": "M"}, {"family": "Vosough", "given": "Massoud", "initials": "M"}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "Front Microbiol", "issn": "1664-302X", "volume": "12", "pages": "785856", "issn-l": null}, "abstract": "Extracellular vesicles (EVs), as nano-/micro-scale vehicles, are membranous particles containing various cargoes including peptides, proteins, different types of RNAs and other nucleic acids, and lipids. These vesicles are produced by all cell types, in which stem cells are a potent source for them. Stem cell-derived EVs could be promising platforms for treatment of infectious diseases and early diagnosis. Infectious diseases are responsible for more than 11 million deaths annually. Highly transmissible nature of some microbes, such as newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), drives researcher's interest to set up different strategies to develop novel therapeutic strategies. Recently, EVs-based diagnostic and therapeutic approaches have been launched and gaining momentum very fast. The efficiency of stem cell-derived EVs on treatment of clinical complications of different viruses and bacteria, such as SARS-CoV-2, hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), Staphylococcus aureus, Escherichia coli has been demonstrated. On the other hand, microbial pathogens are able to incorporate their components into their EVs. The microbe-derived EVs have different physiological and pathological impacts on the other organisms. In this review, we briefly discussed biogenesis and the fate of EVs. Then, EV-based therapy was described and recent developments in understanding the potential application of stem cell-derived EVs on pathogenic microorganisms were recapitulated. Furthermore, the mechanisms by which EVs were exploited to fight against infectious diseases were highlighted. Finally, the deriver challenges in translation of stem cell-derived EVs into the clinical arena were explored.", "doi": "10.3389/fmicb.2021.785856", "pmid": "34917064", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8669997"}], "notes": [], "created": "2021-12-18T17:41:45.760Z", "modified": "2021-12-18T17:42:00.602Z"}, {"entity": "publication", "iuid": "61cb9195191e453f9f426b4888551047", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61cb9195191e453f9f426b4888551047.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61cb9195191e453f9f426b4888551047"}}, "title": "Using Ecological Momentary Assessment to Study the Development of COVID-19 Worries in Sweden: Longitudinal Study.", "authors": [{"family": "Schulz", "given": "Peter Johannes", "initials": "PJ", "orcid": "0000-0003-4281-489X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e186ea7760d84db695253b781d054226.json"}}, {"family": "Andersson", "given": "Elin M", "initials": "EM", "orcid": "0000-0002-9847-4196", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/febdb7c142b048deb0b5ffd9f998f289.json"}}, {"family": "Bizzotto", "given": "Nicole", "initials": "N", "orcid": "0000-0002-4730-1367", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ccad820d0f746ef92ca47b5e24a17fb.json"}}, {"family": "Norberg", "given": "Margareta", "initials": "M", "orcid": "0000-0003-2475-7131", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d9734ccbd5e46c5be2b3922d9af4b81.json"}}], "type": "journal article", "published": "2021-11-29", "journal": {"title": "J Med Internet Res", "issn": "1438-8871", "volume": "23", "issue": "11", "pages": "e26743", "issn-l": null}, "abstract": "The foray of COVID-19 around the globe has certainly instigated worries in many people, and lockdown measures may well have triggered more specific worries. Sweden, more than other countries, relied on voluntary measures to fight the pandemic. This provides a particularly interesting context to assess people's reactions to the threat of the pandemic.\n\nThe general aim of this study was to better understand the worried reactions to the virus and the associated lockdown measures. As there have been very few longitudinal studies in this area published to date, development of feelings of worry over time was analyzed over a longer range than in previous research. Affective variables, worry in particular, were included because most of the research in this field has focused on cognitive variables. To employ new methodology, ecological momentary assessment was used for data collection and a multilevel modeling approach was adopted for data analysis.\n\nResults were based on an unbalanced panel sample of 260 Swedish participants filling in 3226 interview questionnaires by smartphone over a 7-week period in 2020 during the rapid rise of cases in the early phase of the pandemic. Causal factors considered in this study included the perceived severity of an infection, susceptibility of a person to the threat posed by the virus, perceived efficacy of safeguarding measures, and assessment of government action against the spread of COVID-19. The effect of these factors on worries was traced in two analytical steps: the effects at the beginning of the study and the effect on the trend during the study.\n\nThe level of general worry related to COVID-19 was modest (mean 6.67, SD 2.54 on an 11-point Likert scale); the increase during the study period was small, but the interindividual variation of both the worry level and its increase over time was large. Findings confirmed that the hypothesized causal factors (severity of infection, susceptibility to the threat of the virus, efficacy of safeguarding, and assessment of government preventive action) did indeed affect the level of worry.\n\nThe results confirmed earlier research in a very special case and demonstrated the usefulness of a different study design, which takes a longitudinal perspective, and a new type of data analysis borrowed from multilevel study design.", "doi": "10.2196/26743", "pmid": "34847065", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "v23i11e26743"}], "notes": [], "created": "2021-12-18T18:10:14.526Z", "modified": "2021-12-18T18:10:14.690Z"}, {"entity": "publication", "iuid": "383c0fe192104c33b63bb8e5ec51a54a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/383c0fe192104c33b63bb8e5ec51a54a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/383c0fe192104c33b63bb8e5ec51a54a"}}, "title": "The Glomerular Endothelium Restricts Albumin Filtration.", "authors": [{"family": "Ballermann", "given": "Barbara J", "initials": "BJ"}, {"family": "Nystr\u00f6m", "given": "Jenny", "initials": "J"}, {"family": "Haraldsson", "given": "B\u00f6rje", "initials": "B"}], "type": "journal article", "published": "2021-11-29", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "8", "pages": "766689", "issn-l": null}, "abstract": "Inflammatory activation and/or dysfunction of the glomerular endothelium triggers proteinuria in many systemic and localized vascular disorders. Among them are the thrombotic microangiopathies, many forms of glomerulonephritis, and acute inflammatory episodes like sepsis and COVID-19 illness. Another example is the chronic endothelial dysfunction that develops in cardiovascular disease and in metabolic disorders like diabetes. While the glomerular endothelium is a porous sieve that filters prodigious amounts of water and small solutes, it also bars the bulk of albumin and large plasma proteins from passing into the glomerular filtrate. This endothelial barrier function is ascribed predominantly to the endothelial glycocalyx with its endothelial surface layer, that together form a relatively thick, mucinous coat composed of glycosaminoglycans, proteoglycans, glycolipids, sialomucins and other glycoproteins, as well as secreted and circulating proteins. The glycocalyx/endothelial surface layer not only covers the glomerular endothelium; it extends into the endothelial fenestrae. Some glycocalyx components span or are attached to the apical endothelial cell plasma membrane and form the formal glycocalyx. Other components, including small proteoglycans and circulating proteins like albumin and orosomucoid, form the endothelial surface layer and are bound to the glycocalyx due to weak intermolecular interactions. Indeed, bound plasma albumin is a major constituent of the endothelial surface layer and contributes to its barrier function. A role for glomerular endothelial cells in the barrier of the glomerular capillary wall to protein filtration has been demonstrated by many elegant studies. However, it can only be fully understood in the context of other components, including the glomerular basement membrane, the podocytes and reabsorption of proteins by tubule epithelial cells. Discovery of the precise mechanisms that lead to glycocalyx/endothelial surface layer disruption within glomerular capillaries will hopefully lead to pharmacological interventions that specifically target this important structure.", "doi": "10.3389/fmed.2021.766689", "pmid": "34912827", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8667033"}], "notes": [], "created": "2021-12-18T17:48:23.056Z", "modified": "2022-01-04T15:36:39.995Z"}, {"entity": "publication", "iuid": "c3ab6905010440e1a70238b3d4ff0777", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3ab6905010440e1a70238b3d4ff0777.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3ab6905010440e1a70238b3d4ff0777"}}, "title": "Safety and efficacy of the mRNA BNT162b2 vaccine against SARS-CoV-2 in five groups of immunocompromised patients and healthy controls in a prospective open-label clinical trial.", "authors": [{"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Mielke", "given": "Stephan", "initials": "S"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "S\u00f6derdahl", "given": "Gunnar", "initials": "G"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Vesterbacka", "given": "Jan", "initials": "J"}, {"family": "Lindgren", "given": "Gustaf", "initials": "G"}, {"family": "Blixt", "given": "Lisa", "initials": "L"}, {"family": "Friman", "given": "Gustav", "initials": "G"}, {"family": "Wahren-Borgstr\u00f6m", "given": "Emilie", "initials": "E"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Gomez", "given": "Angelica Cuapio", "initials": "AC"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Valentini", "given": "Davide", "initials": "D"}, {"family": "Norlin", "given": "Anna-Carin", "initials": "A"}, {"family": "Thalme", "given": "Anders", "initials": "A"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "Chen", "given": "Margaret S\u00e4llberg", "initials": "MS"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "COVAXID-collaborator group (shown separately)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-29", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": "74", "issue": null, "pages": "103705"}, "abstract": "Patients with immunocompromised disorders have mainly been excluded from clinical trials of vaccination against COVID-19. Thus, the aim of this prospective clinical trial was to investigate safety and efficacy of BNT162b2 mRNA vaccination in five selected groups of immunocompromised patients and healthy controls.\r\n\r\n539 study subjects (449 patients and 90 controls) were included. The patients had either primary (n=90), or secondary immunodeficiency disorders due to human immunodeficiency virus infection (n=90), allogeneic hematopoietic stem cell transplantation/CAR T cell therapy (n=90), solid organ transplantation (SOT) (n=89), or chronic lymphocytic leukemia (CLL) (n=90). The primary endpoint was seroconversion rate two weeks after the second dose. The secondary endpoints were safety and documented SARS-CoV-2 infection.\r\n\r\nAdverse events were generally mild, but one case of fatal suspected unexpected serious adverse reaction occurred. 72.2% of the immunocompromised patients seroconverted compared to 100% of the controls (p=0.004). Lowest seroconversion rates were found in the SOT (43.4%) and CLL (63.3%) patient groups with observed negative impact of treatment with mycophenolate mofetil and ibrutinib, respectively.\r\n\r\nThe results showed that the mRNA BNT162b2 vaccine was safe in immunocompromised patients. Rate of seroconversion was substantially lower than in healthy controls, with a wide range of rates and antibody titres among predefined patient groups and subgroups. This clinical trial highlights the need for additional vaccine doses in certain immunocompromised patient groups to improve immunity.\r\n\r\nKnut and Alice Wallenberg Foundation, the Swedish Research Council, Nordstjernan AB, Region Stockholm, Karolinska Institutet, and organizations for PID/CLL-patients in Sweden.", "doi": "10.1016/j.ebiom.2021.103705", "pmid": "34861491", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Research Area: Vaccine": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S2352-3964(21)00499-0"}, {"db": "pmc", "key": "PMC8629680"}], "notes": [], "created": "2021-12-13T06:18:22.479Z", "modified": "2022-02-08T19:23:35.378Z"}, {"entity": "publication", "iuid": "9772ddb501a945128727b5f4d0cad4da", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9772ddb501a945128727b5f4d0cad4da.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9772ddb501a945128727b5f4d0cad4da"}}, "title": "Evaluation of an Access-Risk-Knowledge (ARK) Platform for Governance of Risk and Change in Complex Socio-Technical Systems", "authors": [{"family": "McDonald", "given": "Nick", "initials": "N"}, {"family": "McKenna", "given": "Lucy", "initials": "L", "orcid": "0000-0002-6035-7656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b86ff32ca1bf48159697fb2fe2f9551b.json"}}, {"family": "Vining", "given": "Rebecca", "initials": "R", "orcid": "0000-0002-2715-8129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6439c14ee8414e53af9294862d552196.json"}}, {"family": "Doyle", "given": "Brian", "initials": "B", "orcid": "0000-0002-9106-9526", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5dadad0ba26f4f6080691dee6f5a74dd.json"}}, {"family": "Liang", "given": "Junli", "initials": "J"}, {"family": "Ward", "given": "Marie E", "initials": "ME", "orcid": "0000-0002-6638-8461", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c905fcea73cc450cbe0e74287b0eb109.json"}}, {"family": "Ulfvengren", "given": "Pernilla", "initials": "P", "orcid": "0000-0002-9709-540X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc00902f545941139d3a4cce8187eae1.json"}}, {"family": "Geary", "given": "Una", "initials": "U"}, {"family": "Guilfoyle", "given": "John", "initials": "J"}, {"family": "Shuhaiber", "given": "Arwa", "initials": "A"}, {"family": "Hernandez", "given": "Julio", "initials": "J", "orcid": "0000-0003-1347-9631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0184091779e41ecbc5d33105d23034c.json"}}, {"family": "Fogarty", "given": "Mary", "initials": "M"}, {"family": "Healy", "given": "Una", "initials": "U"}, {"family": "Tallon", "given": "Christopher", "initials": "C"}, {"family": "Brennan", "given": "Rob", "initials": "R", "orcid": "0000-0001-8236-362X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94edffbb874e4802bba1ef5efb442c4b.json"}}], "type": "journal-article", "published": "2021-11-29", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "23", "pages": "12572", "issn-l": null}, "abstract": null, "doi": "10.3390/ijerph182312572", "pmid": null, "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:56:14.716Z", "modified": "2021-12-12T06:56:14.981Z"}, {"entity": "publication", "iuid": "e7a3924e7b744217b6a3a136c7aadeec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e7a3924e7b744217b6a3a136c7aadeec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e7a3924e7b744217b6a3a136c7aadeec"}}, "title": "Coronavirus disease 2019 in patients with Behcet's disease: a report of 59 cases in Iran.", "authors": [{"family": "Shahram", "given": "Farhad", "initials": "F", "orcid": "0000-0003-1830-6203", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54cc2725d5914d2eb2b8de5bce99c147.json"}}, {"family": "Esalatmanesh", "given": "Kamal", "initials": "K", "orcid": "0000-0001-9675-5237", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b00277eb98524eadbd9d4524e3958a38.json"}}, {"family": "Khabbazi", "given": "Alireza", "initials": "A", "orcid": "0000-0002-9482-6967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c640608a4c7450e9684bcb7b81b6d90.json"}}, {"family": "Rezaieyazdi", "given": "Zahra", "initials": "Z", "orcid": "0000-0001-8731-7999", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cedb94d93a434d37825e67d516b9cd33.json"}}, {"family": "Mirfeizi", "given": "Zahra", "initials": "Z"}, {"family": "Sadeghi", "given": "Alireza", "initials": "A", "orcid": "0000-0002-7406-4790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5682d53ed18245b6a00334b4aaa8c710.json"}}, {"family": "Soroosh", "given": "Mohsen", "initials": "M"}, {"family": "Kavosi", "given": "Hoda", "initials": "H", "orcid": "0000-0003-4762-6943", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b435e9ba4d1c4a999585594ab71664f9.json"}}, {"family": "Alikhani", "given": "Majid", "initials": "M"}, {"family": "Mostafaei", "given": "Shayan", "initials": "S", "orcid": "0000-0002-1966-1306", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24bfddb5f547448e88fa79f34c78ee23.json"}}], "type": "journal article", "published": "2021-11-29", "journal": {"title": "Clin Rheumatol", "issn": "1434-9949", "issn-l": null}, "abstract": "To present the clinical characteristics, disease course, management, and outcomes of COVID-19 infection in patients with Behcet's disease (BD).\n\nIn this retrospective cohort study, we retrieved BD patients with definite diagnosis of COVID-19 infection. Demographic data, comorbidities, features related both to BD and COVID-19 infection, treatments, and outcomes were collected. Comparisons between patients with or without hospitalization were performed. All statistical analyzes were performed using SPSS version 25. We considered p < 0.05 statistically significant.\n\nWe identified 61 episodes of COVID-19 infection in 59 BD patients. The prevalence was 0.69%. The median age was 45 years (IQR = 20), and the median disease duration was 162 months (IQR = 195). BD features were similar except for higher rate of arterial involvement and positive pathergy test in infected patients. Thirty-five episodes (62.5%) happened in non-active patients; 39% had a comorbid disease. COVID manifestations were the same as the general population. Flu-like symptoms were the most common (85%), followed by fever (66%), ageusia/anosmia (56%), headache (51%), and pulmonary involvement (48%). There was no change in BD symptoms in 74%. Fifteen patients (25.4%) were hospitalized, and one patient (1.7%) died. Receiving glucocorticoids (p < 0.03) and cytotoxic drugs (p < 0.02) were associated with an increased rate of hospitalization.\n\nThe incidence of COVID-19 infection in BD patients was not higher than general population in Iran. They showed milder form of disease with lower morbidity and mortality rate. Most were on immunosuppressive drugs, or had a comorbidity apart from BD. No significant effect on BD course was shown. Key Points \u2022 The incidence of COVID-19 infection in patients with Behcet's disease is not higher. \u2022 They showed milder form of infection with lower morbidity and mortality rate. \u2022 No significant effect on Behcet's disease course was shown with COVID19 infection. \u2022 BD patients can be managed according to the guidelines used for general population.", "doi": "10.1007/s10067-021-06004-y", "pmid": "34842999", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10067-021-06004-y"}, {"db": "pmc", "key": "PMC8628030"}], "notes": [], "created": "2021-12-18T18:12:18.769Z", "modified": "2021-12-18T18:12:29.094Z"}, {"entity": "publication", "iuid": "22607e4c502043ae9c2d0bb4e98a8a8f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/22607e4c502043ae9c2d0bb4e98a8a8f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/22607e4c502043ae9c2d0bb4e98a8a8f"}}, "title": "COVID-19 Fear Among Pakistanis: Psychometric Evaluation of the Fear of COVID-19 Scale Using Item Response Theory and Confirmatory Factor Analysis.", "authors": [{"family": "Ullah", "given": "Irfan", "initials": "I", "orcid": "0000-0003-1100-101X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8d5a7e15ae6487cbdda0de3b2a531c3.json"}}, {"family": "Tahir", "given": "Muhammad Junaid", "initials": "MJ", "orcid": "0000-0002-0335-6681", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3192523e30b47e4ba6579ed8ab36661.json"}}, {"family": "Ali", "given": "Sajjad", "initials": "S", "orcid": "0000-0002-8024-5942", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26d9173903254605b87536aacb209621.json"}}, {"family": "Waseem", "given": "Rabia", "initials": "R"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA", "orcid": "0000-0002-1728-8966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6e65a5a97154d159a63cc2ce3f1b7a8.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-11-29", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "pages": "1-16", "issn-l": null}, "abstract": "The Fear of COVID-19 Scale (FCV-19S) assesses the fear of the novel coronavirus disease 2019 (COVID-19) and has been translated and validated into over 20 languages. The present study conducted confirmatory factor analysis (CFA) and item response theory (IRT) analyses on the FCV-19S among a sample of 937 Pakistani adults (mean [SD] age of 25.83 [11.80] years; 537 [57.3%] females). The CFA and IRT confirmed the unidimensionality of the FCV-19S. The Likert-type scale used in the FCV-19S was supported by the proper threshold orderings. Additionally, no DIF contrast had an absolute value larger than 0.5 regarding the participants' characteristics of gender, age, living status, and education in the IRT findings. The FCV-19S was found to be valid and reliable with strong psychometric properties among the Pakistani adult population.", "doi": "10.1007/s11469-021-00656-2", "pmid": "34867122", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "656"}, {"db": "pmc", "key": "PMC8628831"}], "notes": [], "created": "2021-12-13T06:07:01.885Z", "modified": "2021-12-13T06:07:20.741Z"}, {"entity": "publication", "iuid": "61ae5f5a56ba41f4909e80b7caa89fce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61ae5f5a56ba41f4909e80b7caa89fce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61ae5f5a56ba41f4909e80b7caa89fce"}}, "title": "A Survey of Psychiatric Healthcare Workers' Perception of Working Environment and Possibility to Recover Before and After the First Wave of COVID-19 in Sweden.", "authors": [{"family": "Alexiou", "given": "Eirini", "initials": "E"}, {"family": "Steingrimsson", "given": "Steinn", "initials": "S"}, {"family": "Akerstrom", "given": "Magnus", "initials": "M"}, {"family": "Jonsdottir", "given": "Ingibj\u00f6rg H", "initials": "IH"}, {"family": "Ahlstrom", "given": "Linda", "initials": "L"}, {"family": "Finizia", "given": "Caterina", "initials": "C"}, {"family": "Wijk", "given": "Helle", "initials": "H"}, {"family": "Degl'Innocenti", "given": "Alessio", "initials": "A"}], "type": "journal article", "published": "2021-11-29", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "770955", "issn-l": "1664-0640"}, "abstract": "Objective: This study aimed to investigate the impact of the first wave of the COVID-19 pandemic on perceived working environment, including the possibility to recover, among psychiatric healthcare workers (PHCWs) in comparison with pre-pandemic measures. Method: A link to an anonymous, web-based COVID-19 related survey was sent via email to all PHCWs at a university hospital in Sweden (n = 1,618) in September 2020. The response rate was 38% (566 of 1,507 eligible participants). Working environment survey responses collected in 2019 were used as pre-pandemic comparators. Statistical analyses were performed to assess overall impact over time on work demands, support, motivation, and recovery, stratified by professional role, and considering variables such as access to personal protective equipment. Results: The percentage of individuals responding negatively to statements about working environment increased significantly for most items after the first wave. Similarly, the increase of five of the investigated factors indicated a more negative perception of recovery during the pandemic. Registered nurses reported a greater negative impact of the pandemic on perceived working conditions and ability to recover than other professional groups. PHCWs working with patients with COVID-19 (35%) who reported being worried about becoming infected (12%) or infecting others (17%), or lacking adequate personal protective equipment (22%) were more negatively impacted regarding work environment-related items than those who did not. Conclusions: PHCWs' working environment and possibility for recovery were impacted by the first wave of the COVID-19 pandemic, nurses being most affected. Although psychiatric services do not directly care for patients with severe COVID-19 infection, the results from this study suggests that mental health services should also prepare for future pandemics.", "doi": "10.3389/fpsyt.2021.770955", "pmid": "34912253", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8666504"}], "notes": [], "created": "2021-12-18T17:48:55.226Z", "modified": "2022-01-04T15:36:57.557Z"}, {"entity": "publication", "iuid": "70c06bfda3fd453ea00196690a20d869", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70c06bfda3fd453ea00196690a20d869.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70c06bfda3fd453ea00196690a20d869"}}, "title": "The Meaning of Critical Illness for People Suffering From COVID-19: When a Frightening Unreality Becomes Reality.", "authors": [{"family": "Engstr\u00f6m", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0001-6244-6401", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f93844031da44a79bc89f3d73da4477f.json"}}, {"family": "Juuso", "given": "P\u00e4ivi", "initials": "P"}, {"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Nordin", "given": "Anna", "initials": "A"}, {"family": "Str\u00f6mb\u00e4ck", "given": "Ulrica", "initials": "U"}], "type": "journal article", "published": "2021-11-27", "journal": {"title": "Qual Health Res", "issn": "1049-7323", "pages": "10497323211050048", "issn-l": null}, "abstract": "The aim of this study was to elucidate the meaning of critical illness for people with COVID-19. This study used a qualitative design. Thirteen people who were critically ill with COVID-19 during 2020 and admitted to a COVID-19 intensive care unit in northern Sweden participated in the study. Data collection was conducted as individual interviews with a narrative approach, and data were analyzed with phenomenological hermeneutic interpretation. The participants did not think they would get critically ill with this unexpected illness. They experienced terrible nightmares where their relatives had been killed, and they missed their relatives both in their dreams and in reality, as they had not been allowed to be with them due to the virus. Gratefulness was described for surviving. Participants described thoughts of not being able to imagine going through this again. They felt fear and loneliness, as a terrifying unreality had become a reality.", "doi": "10.1177/10497323211050048", "pmid": "34839759", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T18:12:43.579Z", "modified": "2021-12-18T18:12:43.660Z"}, {"entity": "publication", "iuid": "41d9d59911dd4b5cbb0b4bf1de8af240", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41d9d59911dd4b5cbb0b4bf1de8af240.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41d9d59911dd4b5cbb0b4bf1de8af240"}}, "title": "Patients diagnosed with COVID-19 and treated with anakinra: a real-world study in the USA.", "authors": [{"family": "Rich", "given": "Carly", "initials": "C", "orcid": "0000-0003-4717-5855", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07ef31d5e3c64104813c74bdebd028c9.json"}}, {"family": "Eriksson", "given": "Daniel", "initials": "D"}, {"family": "Dolfi", "given": "Fabrizio", "initials": "F"}, {"family": "Jablonska", "given": "Katarzyna", "initials": "K"}, {"family": "Dabbous", "given": "Firas", "initials": "F"}, {"family": "Nazir", "given": "Jameel", "initials": "J"}], "type": "journal article", "published": "2021-11-27", "journal": {"title": "Clin Exp Immunol", "issn": "1365-2249", "issn-l": null}, "abstract": "Anakinra, a recombinant, non-glycosylated human interleukin (IL)-1 receptor antagonist, has been used in real-world clinical practice to manage hyperinflammation in COVID-19. This retrospective, observational study analyses USA hospital inpatient data of patients diagnosed with moderate/severe COVID-19 and treated with anakinra between 1 April and 31 August 2020. Of the 119 patients included in the analysis, 63.9% were male, 48.6% were of black ethnicity and the mean (standard deviation [SD]) age was 64.7 (12.5) years. Mean (SD) time from hospital admission to anakinra initiation was 7.3 (6.1) days. Following anakinra initiation, 73.1% of patients received antibiotics, 55.5% received antithrombotics, and 91.0% received corticosteroids. Overall, 64.7% of patients required intensive care unit (ICU) admittance, and 28.6% received mechanical ventilation following admission. Patients who did not require ICU admittance or who were discharged alive experienced a significantly shorter time between hospital admission and receiving anakinra treatment compared with those admitted to the ICU (5 vs 8 days; p = 0.002) or those who died in hospital (6 vs 9 days; p = 0.01). Patients with myocardial infarction or renal conditions were six times (p < 0.01) and three times (p = 0.01), respectively, more likely to die in hospital than be discharged alive. A longer time from hospital admission until anakinra treatment was associated with significantly higher mortality (p = 0.01). Findings from this real-world study suggest that a shorter time from hospital admission to anakinra treatment is associated with significantly lower ICU admissions and mortality among patients with moderate/severe COVID-19.", "doi": "10.1093/cei/uxab024", "pmid": "35020840", "labels": {"Category: Drug Discovery": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6445008"}], "notes": [], "created": "2022-01-13T20:56:01.552Z", "modified": "2022-01-13T20:56:01.634Z"}, {"entity": "publication", "iuid": "877c283b6bc944c2b65464cc5278954a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/877c283b6bc944c2b65464cc5278954a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/877c283b6bc944c2b65464cc5278954a"}}, "title": "COVID-19 and myocardial infarction - Authors' reply.", "authors": [{"family": "Katsoularis", "given": "Ioannis", "initials": "I"}, {"family": "Fonseca-Rodr\u00edguez", "given": "Osvaldo", "initials": "O"}, {"family": "Farrington", "given": "Paddy", "initials": "P"}, {"family": "Lindmark", "given": "Krister", "initials": "K"}, {"family": "Connolly", "given": "Anne-Marie Fors", "initials": "AF"}], "type": "letter", "published": "2021-11-27", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "398", "issue": "10315", "pages": "1964", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(21)02320-5", "pmid": "34838176", "labels": {"Type: Other": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8616566"}, {"db": "pii", "key": "S0140-6736(21)02320-5"}], "notes": [], "created": "2021-12-18T18:12:54.982Z", "modified": "2023-06-19T14:47:25.471Z"}, {"entity": "publication", "iuid": "978bd8de884f43a484e720b400afd240", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/978bd8de884f43a484e720b400afd240.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/978bd8de884f43a484e720b400afd240"}}, "title": "A multitask transfer learning framework for the prediction of virus-human protein-protein interactions.", "authors": [{"family": "Dong", "given": "Thi Ngan", "initials": "TN", "orcid": "0000-0002-3240-9068", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac25fc1b1e684ea8bfb683a927e62de0.json"}}, {"family": "Brogden", "given": "Graham", "initials": "G"}, {"family": "Gerold", "given": "Gisa", "initials": "G"}, {"family": "Khosla", "given": "Megha", "initials": "M"}], "type": "journal article", "published": "2021-11-27", "journal": {"title": "BMC Bioinformatics", "issn": "1471-2105", "volume": "22", "issue": "1", "pages": "572", "issn-l": null}, "abstract": "Viral infections are causing significant morbidity and mortality worldwide. Understanding the interaction patterns between a particular virus and human proteins plays a crucial role in unveiling the underlying mechanism of viral infection and pathogenesis. This could further help in prevention and treatment of virus-related diseases. However, the task of predicting protein-protein interactions between a new virus and human cells is extremely challenging due to scarce data on virus-human interactions and fast mutation rates of most viruses.\n\nWe developed a multitask transfer learning approach that exploits the information of around 24 million protein sequences and the interaction patterns from the human interactome to counter the problem of small training datasets. Instead of using hand-crafted protein features, we utilize statistically rich protein representations learned by a deep language modeling approach from a massive source of protein sequences. Additionally, we employ an additional objective which aims to maximize the probability of observing human protein-protein interactions. This additional task objective acts as a regularizer and also allows to incorporate domain knowledge to inform the virus-human protein-protein interaction prediction model.\n\nOur approach achieved competitive results on 13 benchmark datasets and the case study for the SARS-COV-2 virus receptor. Experimental results show that our proposed model works effectively for both virus-human and bacteria-human protein-protein interaction prediction tasks. We share our code for reproducibility and future research at https://git.l3s.uni-hannover.de/dong/multitask-transfer .", "doi": "10.1186/s12859-021-04484-y", "pmid": "34837942", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12859-021-04484-y"}, {"db": "pmc", "key": "PMC8626732"}], "notes": [], "created": "2021-12-18T18:13:13.723Z", "modified": "2021-12-18T18:13:13.776Z"}, {"entity": "publication", "iuid": "461999d72d1b4338a4999a7334412c17", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/461999d72d1b4338a4999a7334412c17.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/461999d72d1b4338a4999a7334412c17"}}, "title": "Post-Translational Modification of HMGB1 Disulfide Bonds in Stimulating and Inhibiting Inflammation.", "authors": [{"family": "Andersson", "given": "Ulf", "initials": "U", "orcid": "0000-0003-0316-3860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee9bbcb5111f446e99ff8b68c4027f5c.json"}}, {"family": "Tracey", "given": "Kevin J", "initials": "KJ"}, {"family": "Yang", "given": "Huan", "initials": "H"}], "type": "journal article", "published": "2021-11-26", "journal": {"title": "Cells", "issn": "2073-4409", "volume": "10", "issue": "12", "issn-l": null}, "abstract": "High mobility group box 1 protein (HMGB1), a highly conserved nuclear DNA-binding protein, is a \"damage-associated molecular pattern\" molecule (DAMP) implicated in both stimulating and inhibiting innate immunity. As reviewed here, HMGB1 is an oxidation-reduction sensitive DAMP bearing three cysteines, and the post-translational modification of these residues establishes its proinflammatory and anti-inflammatory activities by binding to different extracellular cell surface receptors. The redox-sensitive signaling mechanisms of HMGB1 also occupy an important niche in innate immunity because HMGB1 may carry other DAMPs and pathogen-associated molecular pattern molecules (PAMPs). HMGB1 with DAMP/PAMP cofactors bind to the receptor for advanced glycation end products (RAGE) which internalizes the HMGB1 complexes by endocytosis for incorporation in lysosomal compartments. Intra-lysosomal HMGB1 disrupts lysosomal membranes thereby releasing the HMGB1-transported molecules to stimulate cytosolic sensors that mediate inflammation. This HMGB1-DAMP/PAMP cofactor pathway slowed the development of HMGB1-binding antagonists for diagnostic or therapeutic use. However, recent discoveries that HMGB1 released from neurons mediates inflammation via the TLR4 receptor system, and that cancer cells express fully oxidized HMGB1 as an immunosuppressive mechanism, offer new paths to targeting HMGB1 for inflammation, pain, and cancer.", "doi": "10.3390/cells10123323", "pmid": "34943830", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "cells10123323"}, {"db": "pmc", "key": "PMC8699546"}], "notes": [], "created": "2022-01-03T15:35:56.729Z", "modified": "2022-01-03T15:35:56.782Z"}, {"entity": "publication", "iuid": "abc9c029bee04f64b31151f71dd181fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abc9c029bee04f64b31151f71dd181fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abc9c029bee04f64b31151f71dd181fa"}}, "title": "COVID-19-specific metabolic imprint yields insights into multiorgan system perturbations.", "authors": [{"family": "Cornillet", "given": "Martin", "initials": "M"}, {"family": "Strunz", "given": "Benedikt", "initials": "B"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Ponzetta", "given": "Andrea", "initials": "A"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Muvva", "given": "Jagadeeswara Rao", "initials": "JR"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Chambers", "given": "Benedict J", "initials": "BJ"}, {"family": "Dzidic", "given": "Majda", "initials": "M"}, {"family": "Filipovic", "given": "Iva", "initials": "I"}, {"family": "Gorin", "given": "Jean-Baptiste", "initials": "JB"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Hertwig", "given": "Laura", "initials": "L"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Kokkinou", "given": "Efthymia", "initials": "E"}, {"family": "Kvedaraite", "given": "Egle", "initials": "E"}, {"family": "Lourda", "given": "Magda", "initials": "M"}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J"}, {"family": "Maucourant", "given": "Christopher", "initials": "C"}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A"}, {"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Perez-Potti", "given": "Andr\u00e9", "initials": "A"}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Sandberg", "given": "John Tyler", "initials": "JT"}, {"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "Svensson", "given": "Mattias", "initials": "M"}, {"family": "Varnaite", "given": "Renata", "initials": "R"}, {"family": "Karolinska KI/K COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4691d38f3268433696d7c65ea235a12b.json"}}], "type": "journal article", "published": "2021-11-26", "journal": {"title": "Eur J Immunol", "issn": "1521-4141", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Corona disease 2019 (COVID-19) affects multiple organ systems. Recent studies have indicated perturbations in the circulating metabolome linked to COVID-19 severity. However, several questions pertain with respect to the metabolome in COVID-19. We performed an in-depth assessment of 1129 unique metabolites in 27 hospitalized COVID-19 patients and integrated results with large-scale proteomic and immunology data to capture multiorgan system perturbations. More than half of the detected metabolic alterations in COVID-19 were driven by patient-specific confounding factors ranging from comorbidities to xenobiotic substances. Systematically adjusting for this, a COVID-19-specific metabolic imprint was defined which, over time, underwent a switch in response to severe acute respiratory syndrome coronavirus-2 seroconversion. Integration of the COVID-19 metabolome with clinical, cellular, molecular, and immunological severity scales further revealed a network of metabolic trajectories aligned with multiple pathways for immune activation, and organ damage including neurological inflammation and damage. Altogether, this resource refines our understanding of the multiorgan system perturbations in severe COVID-19 patients.", "doi": "10.1002/eji.202149626", "pmid": "34837225", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null}, "xrefs": [{"db": "URL", "key": "http://www.covid19cellatlas.com", "description": "http://www.covid19cellatlas.com"}], "notes": [], "created": "2021-11-29T06:50:01.953Z", "modified": "2022-02-14T14:51:25.826Z"}, {"entity": "publication", "iuid": "d57da8e8898541a99e1eb3eeec229a67", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d57da8e8898541a99e1eb3eeec229a67.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d57da8e8898541a99e1eb3eeec229a67"}}, "title": "Working conditions in the long-term care sector: A comparative study of migrant and native workers in Austria and Sweden.", "authors": [{"family": "Simmons", "given": "Cassandra", "initials": "C", "orcid": "0000-0002-3053-4244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d023b23170f4381b3b56e2d0299760c.json"}}, {"family": "Rodrigues", "given": "Ricardo", "initials": "R", "orcid": "0000-0001-8438-4184", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93f762464a28446cadf03fe7c1f3a744.json"}}, {"family": "Szebehely", "given": "Marta", "initials": "M", "orcid": "0000-0001-6956-7329", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f91b8962e79467695591ce7db084b3d.json"}}], "type": "journal article", "published": "2021-11-25", "journal": {"title": "Health Soc Care Community", "issn": "1365-2524", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Increased demand for long-term care (LTC) services alongside precarious working conditions has resulted in labour shortages in the LTC sector, which has led to an increasing share of workers of migrant origin filling these jobs. Previous research on migrant care workers has also highlighted the seeming gap in working conditions relative to native workers. However, lack of disaggregated data on migrant and native care workers, alongside single-case studies, may have concealed potential disadvantages faced by certain groups and insufficiently accounted for differences in migration regimes and organisation of LTC sectors. To address these gaps, we carried out a comparative study on various working conditions of migrant and native LTC workers in Austria and Sweden. Using the international Nordcare survey on care sector working conditions, carried out in Austria in 2017 (n = 792) and in Sweden in 2015 (n = 708), we employed t-tests and multivariate logistic regressions to compare the working conditions of migrant and native carers in home and residential care in each country. We found that worse working conditions in Sweden compared to Austria may be explained by differences in training requirements of the LTC workforce and the relatively large for-profit private sector. Country of origin also plays a paramount role in the differences in working conditions experienced by migrants compared to native care workers, with non-European migrants being more likely to face a number of precarious working conditions. Our findings highlight the need to continue addressing precarious working conditions across the sector, particularly during the COVID-19 pandemic where poor working conditions have been linked to increased COVID-related deaths in nursing homes. Our findings also emphasise the importance of policies that consider the various challenges experienced by different migrant groups in the LTC sector, who may particularly be at risk of presenteeism during the COVID-19 pandemic.", "doi": "10.1111/hsc.13657", "pmid": "34825423", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-12-18T18:18:50.075Z", "modified": "2022-11-22T05:45:43.886Z"}, {"entity": "publication", "iuid": "7a72853feee044088b4630148605d8f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a72853feee044088b4630148605d8f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a72853feee044088b4630148605d8f8"}}, "title": "Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome.", "authors": [{"family": "Masood", "given": "Kiran Iqbal", "initials": "KI"}, {"family": "Yameen", "given": "Maliha", "initials": "M"}, {"family": "Ashraf", "given": "Javeria", "initials": "J"}, {"family": "Shahid", "given": "Saba", "initials": "S"}, {"family": "Mahmood", "given": "Syed Faisal", "initials": "SF"}, {"family": "Nasir", "given": "Asghar", "initials": "A"}, {"family": "Nasir", "given": "Nosheen", "initials": "N"}, {"family": "Jamil", "given": "Bushra", "initials": "B"}, {"family": "Ghanchi", "given": "Najia Karim", "initials": "NK"}, {"family": "Khanum", "given": "Iffat", "initials": "I"}, {"family": "Razzak", "given": "Safina Abdul", "initials": "SA"}, {"family": "Kanji", "given": "Akbar", "initials": "A"}, {"family": "Hussain", "given": "Rabia", "initials": "R"}, {"family": "E Rottenberg", "given": "Martin", "initials": "M"}, {"family": "Hasan", "given": "Zahra", "initials": "Z"}], "type": "journal article", "published": "2021-11-25", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "22958", "issn-l": "2045-2322"}, "abstract": "Understanding key host protective mechanisms against SARS-CoV-2 infection can help improve treatment modalities for COVID-19. We used a blood transcriptome approach to study biomarkers associated with differing severity of COVID-19, comparing severe and mild Symptomatic disease with Asymptomatic COVID-19 and uninfected Controls. There was suppression of antigen presentation but upregulation of inflammatory and viral mRNA translation associated pathways in Symptomatic as compared with Asymptomatic cases. In severe COVID-19, CD177 a neutrophil marker, was upregulated while interferon stimulated genes (ISGs) were downregulated. Asymptomatic COVID-19 cases displayed upregulation of ISGs and humoral response genes with downregulation of ICAM3 and TLR8. Compared across the COVID-19 disease spectrum, we found type I interferon (IFN) responses to be significantly upregulated (IFNAR2, IRF2BP1, IRF4, MAVS, SAMHD1, TRIM1), or downregulated (SOCS3, IRF2BP2, IRF2BPL) in Asymptomatic as compared with mild and severe COVID-19, with the dysregulation of an increasing number of ISGs associated with progressive disease. These data suggest that initial early responses against SARS-CoV-2 may be effectively controlled by ISGs. Therefore, we hypothesize that treatment with type I interferons in the early stage of COVID-19 may limit disease progression by limiting SARS-CoV-2 in the host.", "doi": "10.1038/s41598-021-02489-4", "pmid": "34824360", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-02489-4"}, {"db": "pmc", "key": "PMC8617268"}], "notes": [], "created": "2021-12-18T18:19:04.143Z", "modified": "2021-12-18T18:19:04.157Z"}, {"entity": "publication", "iuid": "2d5318adb0dd496d8f88c3835268cc12", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d5318adb0dd496d8f88c3835268cc12.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d5318adb0dd496d8f88c3835268cc12"}}, "title": "Thrombosis and Bleeding After Implementation of an Intermediate-Dose Prophylactic Anticoagulation Protocol in ICU Patients With COVID-19: A Multicenter Screening Study.", "authors": [{"family": "Al-Abani", "given": "Kais", "initials": "K", "orcid": "0000-0002-1789-1538", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a63c8ea9d2b4263817a82795ff41e55.json"}}, {"family": "Kilhamn", "given": "Naima", "initials": "N", "orcid": "0000-0002-7797-9558", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4eef69c580c944989ee65bdf7a0cdb06.json"}}, {"family": "Maret", "given": "Eva", "initials": "E"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J", "orcid": "0000-0001-8739-7896", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c2fb174ab842c8809900877de8c008.json"}}], "type": "journal article", "published": "2021-11-25", "journal": {"title": "J Intensive Care Med", "issn": "1525-1489", "pages": "8850666211051960", "issn-l": null}, "abstract": "Thrombosis and bleeding after implementation of an intermediate-dose prophylactic anticoagulation protocol in intensive care unit (ICU) patients with coronavirus disease 2019 (COVID-19): a multicenter screening study Background: Venous thromboembolism (VTE) is common among critically ill patients with COVID-19. Information regarding VTE prevalence and bleeding complications after implementation of intermediate-dose prophylactic anticoagulation in such patients is, however, limited. Methods: We performed a prospective, observational study in 6 ICUs in 2 university-affiliated teaching hospitals in Sweden. After implementation of an intermediate-dose prophylactic anticoagulation protocol, we performed ultrasound screening for proximal lower-extremity deep vein thrombosis (DVT) and collected routine computed tomography pulmonary angiography exam results. Results: A total of 100 COVID-19 patients were included from June 21, 2020, through February 18, 2021. During a median follow-up of 120 (IQR, 89-134) days, we found VTE in 37 patients with the majority (78.4%) being diagnosed after ICU arrival. Overall, 20 patients had proximal lower-extremity DVT with 95% being detected on ultrasound screening; 22 patients had pulmonary vascular thrombosis; and 4 patients had venous thrombosis at other sites. A total of 6 patients had both proximal lower-extremity DVT and pulmonary vascular thrombosis. On univariate logistic regression analysis of 14 baseline characteristics, only pre-existing heart failure was associated with VTE (OR 4.67, 95% CI 1.13-19.34). Major and non-major bleeding occurred in 10 and 18 patients, respectively. Conclusions: In our cohort of ICU patients with COVID-19, we observed a high prevalence of VTE and bleeding complications after implementation of intermediate-dose anticoagulation. In approximately half of patients, VTE was identified on screening ultrasound.", "doi": "10.1177/08850666211051960", "pmid": "34821162", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T13:05:15.915Z", "modified": "2021-12-18T18:20:59.763Z"}, {"entity": "publication", "iuid": "e782f8c5f6f74285a6d78de609f94e64", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e782f8c5f6f74285a6d78de609f94e64.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e782f8c5f6f74285a6d78de609f94e64"}}, "title": "Associations between compliance with covid-19 public health recommendations and perceived contagion in others: a self-report study in Swedish university students.", "authors": [{"family": "Andersson", "given": "Claes", "initials": "C", "orcid": "0000-0001-9819-2474", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2dce70574f549a6badd1af98fad130a.json"}}, {"family": "Bendtsen", "given": "Marcus", "initials": "M"}, {"family": "Molander", "given": "Olof", "initials": "O"}, {"family": "Granlund", "given": "Lilian", "initials": "L"}, {"family": "Topooco", "given": "Naira", "initials": "N"}, {"family": "Engstr\u00f6m", "given": "Karin", "initials": "K"}, {"family": "Lindfors", "given": "Petra", "initials": "P"}, {"family": "Berman", "given": "Anne H", "initials": "AH"}], "type": "journal article", "published": "2021-11-25", "journal": {"title": "BMC Res Notes", "issn": "1756-0500", "volume": "14", "issue": "1", "pages": "429", "issn-l": null}, "abstract": "During the COVID pandemic, government authorities worldwide have tried to limit the spread of the virus. Sweden's distinctive feature was the use of voluntary public health recommendations. Few studies have evaluated the effectiveness of this strategy. Based on data collected in the spring of 2020, this study explored associations between compliance with recommendations and observed symptoms of contagion in others, using self-report data from university students.\n\nCompliance with recommendations ranged between 69.7 and 95.7 percent. Observations of moderate symptoms of contagion in \"Someone else I have had contact with\" and \"Another person\" were markedly associated with reported self-quarantine, which is the most restrictive recommendation, complied with by 81.2% of participants. Uncertainty regarding the incidence and severity of contagion in cohabitants was markedly associated with the recommendation to avoid public transportation, a recommendation being followed by 69.7%. It is concluded that students largely followed the voluntary recommendations implemented in Sweden, suggesting that coercive measures were not necessary. Compliance with recommendations were associated with the symptoms students saw in others, and with the perceived risk of contagion in the student's immediate vicinity. It is recommended that voluntary recommendations should stress personal relevance, and that close relatives are at risk.", "doi": "10.1186/s13104-021-05848-6", "pmid": "34823585", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8613723"}, {"db": "pii", "key": "10.1186/s13104-021-05848-6"}], "notes": [], "created": "2021-11-26T13:04:20.837Z", "modified": "2023-06-19T14:24:54.892Z"}, {"entity": "publication", "iuid": "d50564289b6b497dbcea278b78f1c958", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d50564289b6b497dbcea278b78f1c958.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d50564289b6b497dbcea278b78f1c958"}}, "title": "The Paradox of Political Accountability and Deficits in the Preconditions for Service Delivery in Elderly Care: A Qualitative Study of Swedish Politicians", "authors": [{"family": "Porter", "given": "Susann", "initials": "S"}, {"family": "Muhonen", "given": "Tuija", "initials": "T"}], "type": "journal-article", "published": "2021-11-24", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "23", "pages": "12350", "issn-l": null}, "abstract": null, "doi": "10.3390/ijerph182312350", "pmid": null, "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:56:32.225Z", "modified": "2021-12-12T06:56:32.244Z"}, {"entity": "publication", "iuid": "032f79d2b198402daefeca79ebaacd96", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/032f79d2b198402daefeca79ebaacd96.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/032f79d2b198402daefeca79ebaacd96"}}, "title": "Impact of the Covid-19 pandemic on primary care utilization: evidence from Sweden using national register data.", "authors": [{"family": "Ekman", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0001-7630-7904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1f4d8ed39cc483a802c179c1f37c53d.json"}}, {"family": "Arvidsson", "given": "Eva", "initials": "E"}, {"family": "Thulesius", "given": "Hans", "initials": "H"}, {"family": "Wilkens", "given": "Jens", "initials": "J"}, {"family": "Cronberg", "given": "Olof", "initials": "O"}], "type": "journal article", "published": "2021-11-24", "journal": {"title": "BMC Res Notes", "issn": "1756-0500", "volume": "14", "issue": "1", "pages": "424", "issn-l": null}, "abstract": "To analyze changes in primary care utilization as a result of the Covid-19 pandemic. Swedish national register data from 2019 to 2020 on utilization of services were used to compare overall utilization levels and across types of contacts and patient groups. A specific objective was to assess the extent to which remote types of patient consultations were able to compensate for any observed fall in on-site visits. Data were stratified by sex and age to investigate any demographic pattern.\n\nFindings show significant reductions in overall utilization of services as the pandemic occurred in the first quarter of 2020. On-site visits fell during the first wave of the pandemic and rebounded thereafter. Patients over 65 years of age appear to have reduced utilization to a larger extent compared with younger groups. Simultaneously, remote contacts increased from around 12% before the pandemic to 17% of the total number of consultations. However, the net effect of changes in service utilization suggests an overall reduction of around 12 percent in the number of primary care consultations as a result of the pandemic. No differences between men and women were observed. Further research will continue to monitor changes in primary care utilization as the pandemic continues.", "doi": "10.1186/s13104-021-05839-7", "pmid": "34819161", "labels": {"Type: Journal article": null, "Topics: Register-based research": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13104-021-05839-7"}, {"db": "pmc", "key": "PMC8611625"}], "notes": [], "created": "2021-11-26T13:05:55.405Z", "modified": "2021-12-18T18:21:41.694Z"}, {"entity": "publication", "iuid": "f11c8ef92e004250bd551f84fd6c7803", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f11c8ef92e004250bd551f84fd6c7803.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f11c8ef92e004250bd551f84fd6c7803"}}, "title": "The impact of COVID-19 on cancer care and oncology clinical research: an experts' perspective.", "authors": [{"family": "Sessa", "given": "C", "initials": "C"}, {"family": "Cortes", "given": "J", "initials": "J"}, {"family": "Conte", "given": "P", "initials": "P"}, {"family": "Cardoso", "given": "F", "initials": "F"}, {"family": "Choueiri", "given": "T", "initials": "T"}, {"family": "Dummer", "given": "R", "initials": "R"}, {"family": "Lorusso", "given": "P", "initials": "P"}, {"family": "Ottmann", "given": "O", "initials": "O"}, {"family": "Ryll", "given": "B", "initials": "B"}, {"family": "Mok", "given": "T", "initials": "T"}, {"family": "Tempero", "given": "M", "initials": "M"}, {"family": "Comis", "given": "S", "initials": "S"}, {"family": "Oliva", "given": "C", "initials": "C"}, {"family": "Peters", "given": "S", "initials": "S"}, {"family": "Tabernero", "given": "J", "initials": "J"}], "type": "journal article", "published": "2021-11-23", "journal": {"title": "ESMO Open", "issn": "2059-7029", "volume": "7", "issue": "1", "pages": "100339", "issn-l": null}, "abstract": "The coronavirus disease-19 (COVID-19) pandemic promises to have lasting impacts on cancer clinical trials that could lead to faster patient access to new treatments. In this article, an international panel of oncology experts discusses the lasting impacts of the pandemic on oncology clinical trials and proposes solutions for clinical trial stakeholders, with the support of recent data on worldwide clinical trials collected by IQVIA. These lasting impacts and proposed solutions encompass three topic areas. Firstly, acceleration and implementation of new operational approaches to oncology trials with patient-centric, fully decentralized virtual approaches that include remote assessments via telemedicine and remote devices. Geographical differences in the uptake of remote technology, including telemedicine, are discussed in the article, focusing on the impact of the local adoption of new operational approaches. Secondly, innovative clinical trials. The pandemic has highlighted the need for new trial designs that accelerate research and limit risks and burden for patients while driving optimization of clinical trial objectives and endpoints, while testing is being minimized. Areas of considerations for clinical trial stakeholders are discussed in detail. In addition, the COVID-19 pandemic has exposed the underrepresentation of minority groups in clinical trials; the approach for oncology clinical trials to improve generalizability of efficacy and outcomes data is discussed. Thirdly, a new problem-focused collaborative framework between oncology trial stakeholders, including decision makers, to leverage and further accelerate the innovative approaches in clinical research developed during the COVID-19 pandemic. This could shorten timelines for patient access to new treatments by addressing the cultural and technological barriers to adopting new operational approaches and innovative clinical trials. The role of the different stakeholders is described, with the aim of making COVID-19 a catalyst for positive change in oncology clinical research and eventually in cancer care.", "doi": "10.1016/j.esmoop.2021.100339", "pmid": "34953404", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2059-7029(21)00301-X"}, {"db": "pmc", "key": "PMC8608656"}], "notes": [], "created": "2022-01-04T15:25:35.957Z", "modified": "2022-01-04T15:25:35.963Z"}, {"entity": "publication", "iuid": "e67e39136bfb4bfbb52f5866da426b32", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e67e39136bfb4bfbb52f5866da426b32.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e67e39136bfb4bfbb52f5866da426b32"}}, "title": "Self-scored impairments in functioning and disability in post-COVID syndrome following mild COVID-19 infection.", "authors": [{"family": "Norrefalk", "given": "Jan-Rickard", "initials": "JR", "orcid": "0000-0002-7070-3268", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24718b50907344ec9053bfc5d8495f19.json"}}, {"family": "Borg", "given": "Kristian", "initials": "K"}, {"family": "Bileviciute-Ljungar", "given": "Indre", "initials": "I"}], "type": "journal article", "published": "2021-11-23", "journal": {"title": "J Rehabil Med", "issn": "1651-2081", "issn-l": null, "volume": "53", "issue": "11 (November)", "pages": "jrm00239"}, "abstract": "To investigate functioning, activity and disability in people with post-COVID syndrome.\n\nCross-sectional.\n\nParticipants were recruited online via Facebook and a stakeholders' organization for post-COVID syndrome in Sweden.\n\nSociodemographic data and International Classification of Functioning, Disability and Health (ICF)-based questionnaire were collected via an online platform and analysed.\n\nA total of 100 participants were included (mean age 44.5 years, 82% women, 61% with higher education, and 56% working full- or part-time). For the ICF component Body Functions, the most impaired functions were: fatigability and energy drive (98-99%); higher cognitive functions (74-94%); sleep functions (98%); muscle functions (93%); respiratory functions (92%); heart functions (82%); emotional functions (80%); sexual functions (77%); pain problems (56-90%); and thermoregulatory functions (68%). For the component Activity, the most frequent limitations were: handling stressful situations (98%); remunerative employment (95%); recreation and leisure (94%); climbing the stairs (94%); doing housework (84%); and informal socializing (64%). The most frequent degrees of impairment/limitations were light and moderate, except for severe-complete for fatigue, higher cognitive functions, multitasking, handling stressful situations; and recreation and leisure activities.\n\nPost-COVID syndrome following a mild COVID-19 infection can result in impaired body functions and activities. These results support the importance of a multidisciplinary rehabilitation approach for these patients.", "doi": "10.2340/jrm.v53.188", "pmid": "34643243", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC8638742"}], "notes": [], "created": "2021-10-21T05:08:19.835Z", "modified": "2023-06-19T15:16:57.208Z"}, {"entity": "publication", "iuid": "2864668bd1e647ecbd7fe29293402ec6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2864668bd1e647ecbd7fe29293402ec6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2864668bd1e647ecbd7fe29293402ec6"}}, "title": "Risk of severe COVID-19 and mortality in patients with established chronic liver disease: a nationwide matched cohort study.", "authors": [{"family": "Simon", "given": "Tracey G", "initials": "TG"}, {"family": "Hagstr\u00f6m", "given": "Hannes", "initials": "H"}, {"family": "Sharma", "given": "Rajani", "initials": "R"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Roelstraete", "given": "Bjorn", "initials": "B"}, {"family": "Larsson", "given": "Emma", "initials": "E"}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "journal article", "published": "2021-11-23", "journal": {"title": "BMC Gastroenterol", "issn": "1471-230X", "volume": "21", "issue": "1", "pages": "439", "issn-l": null}, "abstract": "Some, but not all, prior studies have suggested that patients with chronic liver disease are at increased risk of contracting COVID-19 and developing more severe disease. However, nationwide data are lacking from well-phenotyped cohorts with liver histology and comparisons to matched general population controls.\n\nWe conducted a nationwide cohort study of all Swedish adults with chronic liver disease (CLD) confirmed by liver biopsy between 1966 and 2017 (n = 42,320), who were alive on February 1, 2020. CLD cases were matched to \u2264 5 population comparators by age, sex, calendar year and county (n = 182,147). Using Cox regression, we estimated multivariable-adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for COVID-19 hospitalization and severe COVID-19 (intensive care admission or death due to COVID-19).\n\nBetween February 1 and July 31, 2020, 161 (0.38%) CLD patients and 435 (0.24%) general population controls were hospitalized with COVID-19 (aHR = 1.36, 95% CI = 1.11-1.66), while 65 (0.15%) CLD patients and 191 (0.10%) controls developed severe COVID-19 (aHR = 1.08, 95% CI = 0.79-1.48). Results were similar in patients with CLD due to alcohol use, nonalcoholic fatty liver disease, viral hepatitis, autoimmune hepatitis, and other etiologies. Among patients with cirrhosis (n = 2549), the aHRs for COVID-19 hospitalization and for severe COVID-19 were 1.08 (95% CI 0.48-2.40) and 1.23 (95% CI = 0.37-4.04), respectively, compared to controls. Moreover, among all patients diagnosed with COVID-19, the presence of underlying CLD was not associated with increased mortality (aHR = 0.85, 95% CI = 0.61-1.19).\n\nIn this nationwide cohort, patients with CLD had a higher risk of hospitalization for COVID-19 compared to the general population, but they did not have an increased risk of developing severe COVID-19.", "doi": "10.1186/s12876-021-02017-8", "pmid": "34814851", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12876-021-02017-8"}, {"db": "pmc", "key": "PMC8609512"}], "notes": [], "created": "2021-11-26T13:18:35.808Z", "modified": "2021-12-10T19:35:57.119Z"}, {"entity": "publication", "iuid": "35aa3cd093fd45d89865f8821d247ed6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/35aa3cd093fd45d89865f8821d247ed6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/35aa3cd093fd45d89865f8821d247ed6"}}, "title": "Changes in young adults' mental well-being before and during the early stage of the COVID-19 pandemic: disparities between ethnic groups in Germany.", "authors": [{"family": "Plenty", "given": "Stephanie", "initials": "S", "orcid": "0000-0001-7994-4829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4ecdc074a5e4829a9938e329048169c.json"}}, {"family": "Bracegirdle", "given": "Chloe", "initials": "C"}, {"family": "Dollmann", "given": "J\u00f6rg", "initials": "J"}, {"family": "Spiegler", "given": "Olivia", "initials": "O"}], "type": "journal article", "published": "2021-11-23", "journal": {"title": "Child Adolesc Psychiatry Ment Health", "issn": "1753-2000", "volume": "15", "issue": "1", "pages": "69", "issn-l": null}, "abstract": "The COVID-19 pandemic resulted in substantial disruptions to the daily lives of young people. Yet knowledge is lacking about changes in mental well-being among young adults, whether those from ethnic minorities were more adversely impacted by the pandemic than the ethnic majority, and the extent to which pandemic-related stressors contributed to any declines in mental well-being.\n\nWe draw on nationally representative German CILS4COVID data, collected early in the pandemic (N = 3517, Mage = 25). Respondents provided information on mental well-being (psychosomatic complaints, anxiety, depression, life satisfaction) and exposure to pandemic-related stressors (financial worries, health worries, discrimination, contact with COVID-19). Responses on mental well-being were matched to responses from two pre-pandemic waves. Individual fixed effects regressions examined ethnic group differences in changes in mental well-being prior to, and at the early stage of, the pandemic. Path analysis tested the role of pandemic-related stressors in declines in mental well-being.\n\nOverall, young adults' mental well-being had improved at the pandemic assessment compared to pre-pandemic assessments, and few ethnic group differences in changes were found. However, greater pandemic-related stressors were associated with worsened mental well-being at the pandemic assessment. Among Asian minorities, indirect effects were found on anxiety via health worries, and on depression via health worries and discrimination. For Turkish, Middle Eastern and African minorities, indirect effects on anxiety and depression were found via health worries.\n\nWe did not find widespread declines in mental well-being among young adults at the early stage of the pandemic, and changes in mental well-being prior to and at the early stage of the pandemic were mostly similar across ethnic German and minority groups. Nevertheless, pandemic-related stressors posed risks for young adults' mental well-being, particularly increased discrimination and health worries among Asian minorities, and health worries among Turkish, Middle Eastern and African minorities.", "doi": "10.1186/s13034-021-00418-x", "pmid": "34814926", "labels": {"Type: Journal article": null, "Topics: Register-based research": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13034-021-00418-x"}, {"db": "pmc", "key": "PMC8609988"}], "notes": [], "created": "2021-11-26T13:17:39.305Z", "modified": "2021-12-18T18:23:44.625Z"}, {"entity": "publication", "iuid": "d1fc8ca94c4b47b8ad6d10438d522bb7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1fc8ca94c4b47b8ad6d10438d522bb7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1fc8ca94c4b47b8ad6d10438d522bb7"}}, "title": "COVID-19 Vaccine Hesitancy in the United States: A Systematic Review", "authors": [{"family": "Yasmin", "given": "Farah", "initials": "F"}, {"family": "Najeeb", "given": "Hala", "initials": "H"}, {"family": "Moeed", "given": "Abdul", "initials": "A"}, {"family": "Naeem", "given": "Unaiza", "initials": "U"}, {"family": "Asghar", "given": "Muhammad Sohaib", "initials": "MS"}, {"family": "Chughtai", "given": "Najeeb Ullah", "initials": "NU"}, {"family": "Yousaf", "given": "Zohaib", "initials": "Z"}, {"family": "Seboka", "given": "Binyam Tariku", "initials": "BT"}, {"family": "Ullah", "given": "Irfan", "initials": "I"}, {"family": "Lin", "given": "Chung Ying", "initials": "CY"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal-article", "published": "2021-11-23", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2021.770985", "pmid": null, "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:52:36.907Z", "modified": "2021-12-12T06:53:00.510Z"}, {"entity": "publication", "iuid": "c4e922a935614f2084722b199ef6635c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c4e922a935614f2084722b199ef6635c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c4e922a935614f2084722b199ef6635c"}}, "title": "A Genetic Trap in Yeast for Inhibitors of SARS-CoV-2 Main Protease.", "authors": [{"family": "Alalam", "given": "Hanna", "initials": "H"}, {"family": "Sigurdard\u00f3ttir", "given": "Sunniva", "initials": "S"}, {"family": "Bourgard", "given": "Catarina", "initials": "C"}, {"family": "Tiukova", "given": "Ievgeniia", "initials": "I", "orcid": "0000-0002-0408-3515", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b86de4d9336b48daa3cd8cd3d2420573.json"}}, {"family": "King", "given": "Ross D", "initials": "RD"}, {"family": "Gr\u00f8tli", "given": "Morten", "initials": "M", "orcid": "0000-0003-3621-4222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0039e14b21d5401a833de03544270f70.json"}}, {"family": "Sunnerhagen", "given": "Per", "initials": "P", "orcid": "0000-0002-0967-8729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89127120ae8b43bea9681b7eadf1872b.json"}}], "type": "journal article", "published": "2021-11-23", "journal": {"title": "mSystems", "issn": "2379-5077", "pages": "e0108721", "issn-l": null}, "abstract": "The ongoing COVID-19 pandemic urges searches for antiviral agents that can block infection or ameliorate its symptoms. Using dissimilar search strategies for new antivirals will improve our overall chances of finding effective treatments. Here, we have established an experimental platform for screening of small molecule inhibitors of the SARS-CoV-2 main protease in Saccharomyces cerevisiae cells, genetically engineered to enhance cellular uptake of small molecules in the environment. The system consists of a fusion of the Escherichia coli toxin MazF and its antitoxin MazE, with insertion of a protease cleavage site in the linker peptide connecting the MazE and MazF moieties. Expression of the viral protease confers cleavage of the MazEF fusion, releasing the MazF toxin from its antitoxin, resulting in growth inhibition. In the presence of a small molecule inhibiting the protease, cleavage is blocked and the MazF toxin remains inhibited, promoting growth. The system thus allows positive selection for inhibitors. The engineered yeast strain is tagged with a fluorescent marker protein, allowing precise monitoring of its growth in the presence or absence of inhibitor. We detect an established main protease inhibitor by a robust growth increase, discernible down to 1 \u03bcM. The system is suitable for robotized large-scale screens. It allows in vivo evaluation of drug candidates and is rapidly adaptable for new variants of the protease with deviant site specificities. IMPORTANCE The COVID-19 pandemic may continue for several years before vaccination campaigns can put an end to it globally. Thus, the need for discovery of new antiviral drug candidates will remain. We have engineered a system in yeast cells for the detection of small molecule inhibitors of one attractive drug target of SARS-CoV-2, its main protease, which is required for viral replication. The ability to detect inhibitors in live cells brings the advantage that only compounds capable of entering the cell and remain stable there will score in the system. Moreover, because of its design in yeast cells, the system is rapidly adaptable for tuning the detection level and eventual modification of the protease cleavage site in the case of future mutant variants of the SARS-CoV-2 main protease or even for other proteases.", "doi": "10.1128/mSystems.01087-21", "pmid": "34812651", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Funder: VR": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC8609969"}], "notes": [], "created": "2021-11-26T13:20:05.776Z", "modified": "2021-12-10T17:56:45.258Z"}, {"entity": "publication", "iuid": "8b4f25b4edb743179b967a65d0b202dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b4f25b4edb743179b967a65d0b202dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b4f25b4edb743179b967a65d0b202dd"}}, "title": "Population-based study of multisystem inflammatory syndrome associated with COVID-19 found that 36% of children had persistent symptoms.", "authors": [{"family": "Kahn", "given": "Robin", "initials": "R", "orcid": "0000-0002-3167-1179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ac84bfddfbf425bad7a1484aa57414c.json"}}, {"family": "Berg", "given": "Stefan", "initials": "S"}, {"family": "Berntson", "given": "Lillemor", "initials": "L", "orcid": "0000-0003-3962-0453", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56b35f89d1b749b6bb447932384fe4d2.json"}}, {"family": "Berthold", "given": "Elisabet", "initials": "E"}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}, {"family": "B\u00e4ckstr\u00f6m", "given": "Fredrik", "initials": "F"}, {"family": "Compagno", "given": "Michele", "initials": "M"}, {"family": "Fasth", "given": "Anders", "initials": "A", "orcid": "0000-0002-0033-740X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f29cd19b2c7544bb83ce6879ffba2dc6.json"}}, {"family": "Lingman Framme", "given": "Jenny", "initials": "J"}, {"family": "Horne", "given": "AnnaCarin", "initials": "A"}, {"family": "H\u00e4tting", "given": "Josefin", "initials": "J"}, {"family": "Kr\u00f3l", "given": "Petra", "initials": "P"}, {"family": "Kukka", "given": "Antti J", "initials": "AJ"}, {"family": "Mossberg", "given": "Maria", "initials": "M"}, {"family": "M\u00e5nsson", "given": "Bengt", "initials": "B"}, {"family": "Nordenh\u00e4ll", "given": "Charlotta", "initials": "C"}, {"family": "Idring Nordstr\u00f6m", "given": "Selma", "initials": "S"}, {"family": "Khammari Nystr\u00f6m", "given": "Fatine", "initials": "F"}, {"family": "Palmblad", "given": "Karin", "initials": "K"}, {"family": "Rasti", "given": "Reza", "initials": "R"}, {"family": "Rudolph", "given": "Andr\u00e9", "initials": "A"}, {"family": "Rydenman", "given": "Karin", "initials": "K"}, {"family": "Sundberg", "given": "Erik", "initials": "E"}, {"family": "S\u00e4ve-S\u00f6derbergh", "given": "Eva", "initials": "E"}, {"family": "Altman", "given": "Maria", "initials": "M", "orcid": "0000-0001-8316-0154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9efee5220a52450fa208d78ef82a0e20.json"}}], "type": "journal article", "published": "2021-11-22", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253"}, "abstract": "Our aim was to describe the outcomes of multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19.\n\nThis national, population-based, longitudinal, multicentre study used Swedish data that were prospectively collected between 1 December 2020 and 31 May 2021. All patients met the World Health Organization criteria for MIS-C. The outcomes 2 and 8 weeks after diagnosis are presented, and follow-up protocols are suggested.\n\nWe identified 152 cases, and 133 (87%) participated. When followed up 2 weeks after MIS-C was diagnosed, 43% of the 119 patients had abnormal results, including complete blood cell counts, platelet counts, albumin levels, electrocardiograms and echocardiograms. After 8 weeks, 36% of 89 had an abnormal patient history, but clinical findings were uncommon. Echocardiogram results were abnormal in 5% of 67, and the most common complaint was fatigue. Older children and those who received intensive care were more likely to report symptoms and have abnormal cardiac results.\n\nMore than a third (36%) of the patients had persistent symptoms 8 weeks after MIS-C, and 5% had abnormal echocardiograms. Older age and higher levels of initial care appeared to be risk factors. Structured follow-up visits are important after MIS-C.", "doi": "10.1111/apa.16191", "pmid": "34806789", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T13:55:47.806Z", "modified": "2021-12-10T18:07:00.711Z"}, {"entity": "publication", "iuid": "c06d810ebd4b428ea3e8bf99e4f1872c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c06d810ebd4b428ea3e8bf99e4f1872c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c06d810ebd4b428ea3e8bf99e4f1872c"}}, "title": "Influenza outcomes in patients with inflammatory joint diseases and DMARDs: how do they compare to those of COVID-19?", "authors": [{"family": "Bower", "given": "Hannah", "initials": "H", "orcid": "0000-0002-2046-3833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac82ea2714c34d58a762b3cc168cbd4a.json"}}, {"family": "Frisell", "given": "Thomas", "initials": "T", "orcid": "0000-0002-5735-9626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e9d6be8c47b4d6eb80bd3d57a63172e.json"}}, {"family": "Di Giuseppe", "given": "Daniela", "initials": "D"}, {"family": "Delcoigne", "given": "B\u00e9n\u00e9dicte", "initials": "B"}, {"family": "Askling", "given": "Johan", "initials": "J", "orcid": "0000-0003-0433-0616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26359d7da52744208ca84bc65a5401cb.json"}}], "type": "journal article", "published": "2021-11-22", "journal": {"title": "Ann Rheum Dis", "issn": "1468-2060", "issn-l": null}, "abstract": "To estimate absolute and relative risks for seasonal influenza outcomes in patients with inflammatory joint diseases (IJDs) and disease-modifying antirheumatic drugs (DMARDs). To contextualise recent findings on corresponding COVID-19 risks.\n\nUsing Swedish nationwide registers for this cohort study, we followed 116 989 patients with IJD and matched population comparators across four influenza seasons (2015-2019). We quantified absolute risks of hospitalisation and death due to influenza, and compared IJD to comparators via Cox regression. We identified 71 556 patients with IJD on active treatment with conventional synthetic DMARDs and biological disease-modifying antirheumatic drugs (bDMARDs)/targeted synthetic disease-modifying antirheumatic drug (tsDMARDs) at the start of each influenza season, estimated risks for the same outcomes and compared these risks across DMARDs via Cox regression.\n\nPer season, average risks for hospitalisation listing influenza were 0.25% in IJD and 0.1% in the general population, corresponding to a crude HR of 2.38 (95% CI 2.21 to 2.56) that decreased to 1.44 (95% CI 1.33 to 1.56) following adjustments for comorbidities. For death listing influenza, the corresponding numbers were 0.015% and 0.006% (HR=2.63, 95% CI 1.93 to 3.58, and HR=1.46, 95% CI 1.07 to 2.01). Absolute risks for influenza outcomes were half (hospitalisation) and one-tenth (death) of those for COVID-19, but relative estimates comparing IJD to the general population were similar.\n\nIn absolute terms, COVID-19 in IJD outnumbers that of average seasonal influenza, but IJD entails a 50%-100% increase in risk for hospitalisation and death for both types of infections, which is largely dependent on associated comorbidities. Overall, bDMARDs/tsDMARDs do not seem to confer additional risk for hospitalisation or death related to seasonal influenza.", "doi": "10.1136/annrheumdis-2021-221461", "pmid": "34810197", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "annrheumdis-2021-221461"}, {"db": "pmc", "key": "PMC8610614"}], "notes": [], "created": "2021-11-26T13:53:59.516Z", "modified": "2021-12-10T18:04:20.305Z"}, {"entity": "publication", "iuid": "22fb1f7377424f5692811dbdffbf56d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/22fb1f7377424f5692811dbdffbf56d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/22fb1f7377424f5692811dbdffbf56d4"}}, "title": "Functional Antibodies Against SARS-CoV-2 Receptor Binding Domain Variants with Mutations N501Y or E484K in Human Milk from COVID-19-Vaccinated, -Recovered, and -Unvaccinated Women.", "authors": [{"family": "Demers-Mathieu", "given": "Veronique", "initials": "V", "orcid": "0000-0002-7937-6355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db7be05c02af4ba8a72768cd239f1f5e.json"}}, {"family": "Hakansson", "given": "Anders P", "initials": "AP"}, {"family": "Hall", "given": "Stephanie", "initials": "S"}, {"family": "Lavangnananda", "given": "Sirima", "initials": "S"}, {"family": "Fels", "given": "Shawn", "initials": "S"}, {"family": "Medo", "given": "Elena", "initials": "E"}], "type": "journal article", "published": "2021-11-22", "journal": {"title": "Breastfeed Med", "issn": "1556-8342", "issn-l": null}, "abstract": "New variants are evolving in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and receptor binding domain (RBD) mutations have been associated with a higher capacity to evade neutralizing antibodies (NAbs). We aimed at determining the impact of COVID-19 vaccine and infection on human milk antibody titers and activity against the RBD mutations from SARS-CoV-2 variants of concern. Background: Milk samples were collected from 19 COVID-19 vaccinated women, 10 women who had a positive COVID-19 PCR test, and 13 unvaccinated women. The titers and NAbs of secretory IgA (SIgA)/IgA, secretory IgM (IgM)/IgM, and IgG against SARS-CoV-2 RBD with mutations N501Y or E484K were measured by using ELISA and a surrogate virus neutralization assay. Materials and Methods: The titers of human milk IgG against N501Y were higher in the COVID-19 vaccine group than in the no-vaccine group but comparable with the COVID-19 PCR group. Other antibody titers did not differ between the three groups. The titers of SIgA/IgA were higher than those of SIgM/IgM and IgG in all three groups. The titers of SIgM/IgM and the inhibition of NAbs were higher against the mutation E484K than N501Y. Milk NAb did not differ between the three groups, but the inhibition of NAb against binding of the two mutant RBD proteins to their receptor was higher in the COVID-19 vaccine and PCR groups than in milk from prepandemic women. Results: COVID-19 vaccination and exposure of mothers to SARS-CoV-2 influenced the titers and NAbs in breast milk against the variants of concern.Conclusions:", "doi": "10.1089/bfm.2021.0232", "pmid": "34809492", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-11-26T13:54:16.969Z", "modified": "2021-12-10T18:05:02.477Z"}, {"entity": "publication", "iuid": "32657b84d5e64b6791e48042b4c0dbbb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/32657b84d5e64b6791e48042b4c0dbbb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/32657b84d5e64b6791e48042b4c0dbbb"}}, "title": "Drivers and social implications of Artificial Intelligence adoption in healthcare during the COVID-19 pandemic.", "authors": [{"family": "Frank", "given": "Darius-Aurel", "initials": "DA", "orcid": "0000-0002-1577-7352", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0a5cb4ef9514e01a08632ec84866fbf.json"}}, {"family": "Elb\u00e6k", "given": "Christian T", "initials": "CT", "orcid": "0000-0002-7039-4565", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a44f489ddccb4a208ec453424a471bfc.json"}}, {"family": "B\u00f8rsting", "given": "Caroline Kj\u00e6r", "initials": "CK"}, {"family": "Mitkidis", "given": "Panagiotis", "initials": "P"}, {"family": "Otterbring", "given": "Tobias", "initials": "T"}, {"family": "Borau", "given": "Sylvie", "initials": "S"}], "type": "journal article", "published": "2021-11-22", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "11", "pages": "e0259928", "issn-l": "1932-6203"}, "abstract": "The COVID-19 pandemic continues to impact people worldwide-steadily depleting scarce resources in healthcare. Medical Artificial Intelligence (AI) promises a much-needed relief but only if the technology gets adopted at scale. The present research investigates people's intention to adopt medical AI as well as the drivers of this adoption in a representative study of two European countries (Denmark and France, N = 1068) during the initial phase of the COVID-19 pandemic. Results reveal AI aversion; only 1 of 10 individuals choose medical AI over human physicians in a hypothetical triage-phase of COVID-19 pre-hospital entrance. Key predictors of medical AI adoption are people's trust in medical AI and, to a lesser extent, the trait of open-mindedness. More importantly, our results reveal that mistrust and perceived uniqueness neglect from human physicians, as well as a lack of social belonging significantly increase people's medical AI adoption. These results suggest that for medical AI to be widely adopted, people may need to express less confidence in human physicians and to even feel disconnected from humanity. We discuss the social implications of these findings and propose that successful medical AI adoption policy should focus on trust building measures-without eroding trust in human physicians.", "doi": "10.1371/journal.pone.0259928", "pmid": "34807907", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-20575"}, {"db": "pmc", "key": "PMC8608336"}], "notes": [], "created": "2021-11-26T13:55:05.093Z", "modified": "2021-12-10T18:06:08.493Z"}, {"entity": "publication", "iuid": "7b2ef4c42a3d47fc89c04b015438c234", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b2ef4c42a3d47fc89c04b015438c234.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b2ef4c42a3d47fc89c04b015438c234"}}, "title": "Accessible data curation and analytics for international-scale citizen science datasets.", "authors": [{"family": "Murray", "given": "Benjamin", "initials": "B", "orcid": "0000-0002-2413-923X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebec738df0224bf4874fd6c08fd23fae.json"}}, {"family": "Kerfoot", "given": "Eric", "initials": "E"}, {"family": "Chen", "given": "Liyuan", "initials": "L"}, {"family": "Deng", "given": "Jie", "initials": "J"}, {"family": "Graham", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-4170-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f5f4e19812a46ed9e873732ec25e28d.json"}}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Molteni", "given": "Erika", "initials": "E", "orcid": "0000-0001-7773-8140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9aed1fbe444b48d4bfacb12050953c8e.json"}}, {"family": "Canas", "given": "Liane S", "initials": "LS", "orcid": "0000-0002-2553-1284", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c8d4abc0be246a1b77bf183be19efb6.json"}}, {"family": "Antonelli", "given": "Michela", "initials": "M"}, {"family": "Klaser", "given": "Kerstin", "initials": "K"}, {"family": "Visconti", "given": "Alessia", "initials": "A", "orcid": "0000-0003-4144-2019", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ce0429ccf674827aedbb8d05a53145c.json"}}, {"family": "Hammers", "given": "Alexander", "initials": "A", "orcid": "0000-0001-9530-4848", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aade93dbff2d4187a039a8e50027ed9c.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-7284-6767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeefbf47fd384d5390109fe1a903bd18.json"}}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Davies", "given": "Richard", "initials": "R", "orcid": "0000-0003-2050-3994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b82cc92615f462d9af0153a6fb94fde.json"}}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Modat", "given": "Marc", "initials": "M"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}], "type": "journal article", "published": "2021-11-22", "journal": {"title": "Sci Data", "issn": "2052-4463", "issn-l": null, "volume": "8", "issue": "1", "pages": "297"}, "abstract": "The Covid Symptom Study, a smartphone-based surveillance study on COVID-19 symptoms in the population, is an exemplar of big data citizen science. As of May 23rd, 2021, over 5 million participants have collectively logged over 360 million self-assessment reports since its introduction in March 2020. The success of the Covid Symptom Study creates significant technical challenges around effective data curation. The primary issue is scale. The size of the dataset means that it can no longer be readily processed using standard Python-based data analytics software such as Pandas on commodity hardware. Alternative technologies exist but carry a higher technical complexity and are less accessible to many researchers. We present ExeTera, a Python-based open source software package designed to provide Pandas-like data analytics on datasets that approach terabyte scales. We present its design and capabilities, and show how it is a critical component of a data curation pipeline that enables reproducible research across an international research group for the Covid Symptom Study.", "doi": "10.1038/s41597-021-01071-x", "pmid": "34811392", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41597-021-01071-x"}, {"db": "pmc", "key": "PMC8608807"}, {"db": "URL", "key": "https://github.com/KCL-BMEIS/ExeTera", "description": "https://github.com/KCL-BMEIS/ExeTera"}, {"db": "URL", "key": "https://github.com/KCL-BMEIS/ExeTera/wiki", "description": "https://github.com/KCL-BMEIS/ExeTera/wiki"}], "notes": [], "created": "2021-11-26T13:50:02.786Z", "modified": "2021-12-10T18:03:32.696Z"}, {"entity": "publication", "iuid": "15305e51a3c54f05ae698e9df0084837", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15305e51a3c54f05ae698e9df0084837.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15305e51a3c54f05ae698e9df0084837"}}, "title": "Defining the impact of SARS-COV-2 on delivery of CAR T-cell therapy in Europe: a retrospective survey from the CTIWP of the EBMT.", "authors": [{"family": "Ghorashian", "given": "Sara", "initials": "S", "orcid": "0000-0002-1555-2946", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fec721406a44d8983774c214511454d.json"}}, {"family": "Malard", "given": "Florent", "initials": "F"}, {"family": "Y\u00fcksel", "given": "Meltem Kurt", "initials": "MK"}, {"family": "Mauff", "given": "Katya", "initials": "K"}, {"family": "Hoogenboom", "given": "Jorinde D", "initials": "JD"}, {"family": "Urbano-Ispizua", "given": "Alvaro", "initials": "A"}, {"family": "Kuball", "given": "J\u00fcrgen", "initials": "J", "orcid": "0000-0002-3914-7806", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93b68b37f90949f681e03905510def84.json"}}, {"family": "de la Camara", "given": "Rafael", "initials": "R", "orcid": "0000-0002-8189-5779", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/868bc0284ac640a1bf215e7d7cc86da3.json"}}, {"family": "Ljungman", "given": "Per", "initials": "P", "orcid": "0000-0002-8281-3245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4546eb504184683ab712eee858ea9cb.json"}}, {"family": "Ruggeri", "given": "Annalisa", "initials": "A"}, {"family": "Chabannon", "given": "Christian", "initials": "C", "orcid": "0000-0002-3755-4889", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6383ab718ee423da23a515b971751bc.json"}}], "type": "letter", "published": "2021-11-20", "journal": {"title": "Bone Marrow Transplant", "issn": "1476-5365", "issn-l": "0268-3369"}, "abstract": null, "doi": "10.1038/s41409-021-01483-8", "pmid": "34802048", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41409-021-01483-8"}, {"db": "pmc", "key": "PMC8605455"}], "notes": [], "created": "2021-11-26T13:56:54.008Z", "modified": "2021-12-10T17:55:26.855Z"}, {"entity": "publication", "iuid": "21d56c12669e4c4fa3c217c0af208c34", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/21d56c12669e4c4fa3c217c0af208c34.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/21d56c12669e4c4fa3c217c0af208c34"}}, "title": "Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials.", "authors": [{"family": "Axfors", "given": "Cathrine", "initials": "C"}, {"family": "Janiaud", "given": "Perrine", "initials": "P"}, {"family": "Schmitt", "given": "Andreas M", "initials": "AM"}, {"family": "Van't Hooft", "given": "Janneke", "initials": "J"}, {"family": 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"initials": "Y"}, {"family": "Webb", "given": "Steve A", "initials": "SA"}, {"family": "Wiese", "given": "Lothar", "initials": "L"}, {"family": "Wik\u00e9n", "given": "Christian", "initials": "C"}, {"family": "Wood", "given": "Erica M", "initials": "EM"}, {"family": "Yusubalieva", "given": "Gaukhar M", "initials": "GM"}, {"family": "Zacharowski", "given": "Kai", "initials": "K"}, {"family": "Zarychanski", "given": "Ryan", "initials": "R"}, {"family": "Khanna", "given": "Nina", "initials": "N"}, {"family": "Moher", "given": "David", "initials": "D"}, {"family": "Goodman", "given": "Steven N", "initials": "SN"}, {"family": "Ioannidis", "given": "John P A", "initials": "JPA"}, {"family": "Hemkens", "given": "Lars G", "initials": "LG"}], "type": "journal article", "published": "2021-11-20", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "volume": "21", "issue": "1", "pages": "1170", "issn-l": null}, "abstract": "Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment and all-cause mortality in patients with COVID-19, using data from all available randomized clinical trials, including unpublished and ongoing trials (Open Science Framework, https://doi.org/10.17605/OSF.IO/GEHFX ).\n\nIn this collaborative systematic review and meta-analysis, clinical trial registries (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform), the Cochrane COVID-19 register, the LOVE database, and PubMed were searched until April 8, 2021. Investigators of trials registered by March 1, 2021, without published results were contacted via email. Eligible were ongoing, discontinued and completed randomized clinical trials that compared convalescent plasma with placebo or no treatment in COVID-19 patients, regardless of setting or treatment schedule. Aggregated mortality data were extracted from publications or provided by investigators of unpublished trials and combined using the Hartung-Knapp-Sidik-Jonkman random effects model. We investigated the contribution of unpublished trials to the overall evidence.\n\nA total of 16,477 patients were included in 33 trials (20 unpublished with 3190 patients, 13 published with 13,287 patients). 32 trials enrolled only hospitalized patients (including 3 with only intensive care unit patients). Risk of bias was low for 29/33 trials. Of 8495 patients who received convalescent plasma, 1997 died (23%), and of 7982 control patients, 1952 died (24%). The combined risk ratio for all-cause mortality was 0.97 (95% confidence interval: 0.92; 1.02) with between-study heterogeneity not beyond chance (I2 = 0%). The RECOVERY trial had 69.8% and the unpublished evidence 25.3% of the weight in the meta-analysis.\n\nConvalescent plasma treatment of patients with COVID-19 did not reduce all-cause mortality. These results provide strong evidence that convalescent plasma treatment for patients with COVID-19 should not be used outside of randomized trials. Evidence synthesis from collaborations among trial investigators can inform both evidence generation and evidence application in patient care.", "doi": "10.1186/s12879-021-06829-7", "pmid": "34800996", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12879-021-06829-7"}, {"db": "pmc", "key": "PMC8605464"}, {"db": "URL", "key": "Open Science Framework https://osf.io/gehfx/", "description": "https://osf.io/gehfx/"}], "notes": [], "created": "2021-11-26T13:57:19.972Z", "modified": "2021-11-26T13:58:22.778Z"}, {"entity": "publication", "iuid": "ba87bfd694b0454f8117a4874c4dd903", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ba87bfd694b0454f8117a4874c4dd903.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ba87bfd694b0454f8117a4874c4dd903"}}, "title": "Parturient with Covid-19 and need for intensive care: an observational study in the Nordic countries.", "authors": [{"family": "Karlsson", "given": "Ove", "initials": "O"}, {"family": "Hein", "given": "Anette", "initials": "A"}, {"family": "Eriksson", "given": "Susanne Ledin", "initials": "SL"}, {"family": "Pettersson", "given": "Karin", "initials": "K"}], "type": "letter", "published": "2021-11-19", "journal": {"title": "Am J Obstet Gynecol MFM", "issn": "2589-9333", "pages": "100532", "issn-l": null}, "abstract": null, "doi": "10.1016/j.ajogmf.2021.100532", "pmid": "34808399", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2589-9333(21)00228-7"}, {"db": "pmc", "key": "PMC8603919"}], "notes": [], "created": "2021-11-26T13:54:43.704Z", "modified": "2021-12-10T18:05:37.974Z"}, {"entity": "publication", "iuid": "2204d45084694f919be24fa50620fda0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2204d45084694f919be24fa50620fda0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2204d45084694f919be24fa50620fda0"}}, "title": "Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities.", "authors": [{"family": "Kruse", "given": "Thomas", "initials": "T"}, {"family": "Benz", "given": "Caroline", "initials": "C", "orcid": "0000-0002-5166-3598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13332514bfe7460db4a0f134718aa211.json"}}, {"family": "Garvanska", "given": "Dimitriya H", "initials": "DH"}, {"family": "Lindqvist", "given": "Richard", "initials": "R"}, {"family": "Mihalic", "given": "Filip", "initials": "F"}, {"family": "Coscia", "given": "Fabian", "initials": "F"}, {"family": "Inturi", "given": "Raviteja", "initials": "R", "orcid": "0000-0003-1344-3962", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6636c43ae584420fbe80f82393225824.json"}}, {"family": "Sayadi", "given": "Ahmed", "initials": "A"}, {"family": "Simonetti", "given": "Leandro", "initials": "L", "orcid": "0000-0003-1283-9770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9ef81e96c104878a6ccea620fc95400.json"}}, {"family": "Nilsson", "given": "Emma", "initials": "E"}, {"family": "Ali", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-8858-6776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0515e4fd072741b0a01456320bbf73de.json"}}, {"family": "Kliche", "given": "Johanna", "initials": "J"}, {"family": "Moliner Morro", "given": "Ainhoa", "initials": "A"}, {"family": "Mund", "given": "Andreas", "initials": "A", "orcid": "0000-0002-7843-5341", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e533a4bd6914e68be49773ccf0db693.json"}}, {"family": "Andersson", "given": "Eva", "initials": "E"}, {"family": "McInerney", "given": "Gerald", "initials": "G", "orcid": "0000-0003-2257-7241", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7770437d845444a8a07865bf5b62fab0.json"}}, {"family": "Mann", "given": "Matthias", "initials": "M"}, {"family": "Jemth", "given": "Per", "initials": "P", "orcid": "0000-0003-1516-7228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c5fe566cf5f44df9c98bb2b1d7078ba.json"}}, {"family": "Davey", "given": "Norman E", "initials": "NE"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK", "orcid": "0000-0001-6553-0940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9024ab251cf44bffbf3229ec909343af.json"}}, {"family": "Nilsson", "given": "Jakob", "initials": "J", "orcid": "0000-0003-4100-1125", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f2ecaef653e54c63b20d88574c03b8b2.json"}}, {"family": "Ivarsson", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-7081-3846", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b3cf0504a1b476f906c4b3e22b05d5a.json"}}], "type": "journal article", "published": "2021-11-19", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "6761"}, "abstract": "Viral proteins make extensive use of short peptide interaction motifs to hijack cellular host factors. However, most current large-scale methods do not identify this important class of protein-protein interactions. Uncovering peptide mediated interactions provides both a molecular understanding of viral interactions with their host and the foundation for developing novel antiviral reagents. Here we describe a viral peptide discovery approach covering 23 coronavirus strains that provides high resolution information on direct virus-host interactions. We identify 269 peptide-based interactions for 18 coronaviruses including a specific interaction between the human G3BP1/2 proteins and an \u03a6xFG peptide motif in the SARS-CoV-2 nucleocapsid (N) protein. This interaction supports viral replication and through its \u03a6xFG motif N rewires the G3BP1/2 interactome to disrupt stress granules. A peptide-based inhibitor disrupting the G3BP1/2-N interaction dampened SARS-CoV-2 infection showing that our results can be directly translated into novel specific antiviral reagents.", "doi": "10.1038/s41467-021-26498-z", "pmid": "34799561", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null, "Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC8605023"}, {"db": "pii", "key": "10.1038/s41467-021-26498-z"}], "notes": [], "created": "2021-11-26T14:03:59.548Z", "modified": "2023-06-19T15:06:00.564Z"}, {"entity": "publication", "iuid": "57ffc67fec3d47b49ba7cb301f827abc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/57ffc67fec3d47b49ba7cb301f827abc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/57ffc67fec3d47b49ba7cb301f827abc"}}, "title": "High sleep fragmentation parallels poor subjective sleep quality during the third wave of the Covid-19 pandemic: An actigraphic study.", "authors": [{"family": "Conte", "given": "Francesca", "initials": "F", "orcid": "0000-0002-5429-5831", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25298eaae41b49a58d9103796937f69e.json"}}, {"family": "De Rosa", "given": "Oreste", "initials": "O"}, {"family": "Rescott", "given": "Marissa Lynn", "initials": "ML"}, {"family": "Arabia", "given": "Teresa Pia", "initials": "TP"}, {"family": "D'Onofrio", "given": "Paolo", "initials": "P"}, {"family": "Lustro", "given": "Alessio", "initials": "A"}, {"family": "Malloggi", "given": "Serena", "initials": "S", "orcid": "0000-0003-1813-8916", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb2487e0d35c41f8b75fba2f7a6441d2.json"}}, {"family": "Molinaro", "given": "Danila", "initials": "D"}, {"family": "Spagnoli", "given": "Paola", "initials": "P"}, {"family": "Giganti", "given": "Fiorenza", "initials": "F", "orcid": "0000-0002-9362-5258", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/99e3ab3bd59b425ab8b21b806500774e.json"}}, {"family": "Barbato", "given": "Giuseppe", "initials": "G", "orcid": "0000-0001-6523-5327", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47264cf640f74008afde9622672a452d.json"}}, {"family": "Ficca", "given": "Gianluca", "initials": "G", "orcid": "0000-0001-9519-4351", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c00e9acb5674411ac84ab79c36b8b22.json"}}], "type": "journal article", "published": "2021-11-19", "journal": {"title": "J Sleep Res", "issn": "1365-2869", "pages": "e13519", "issn-l": "0962-1105"}, "abstract": "Studies on sleep during the Covid-19 pandemic have mostly been conducted during the first wave of contagion (spring 2020). To follow up on two Italian studies addressing subjective sleep features during the second wave (autumn 2020), here we assess sleep during the third wave (spring 2021) in a sample of healthy adults from Campania (Southern Italy). Actigraphic data (on 2 nights) and the Pittsburgh Sleep Quality Index were collected from 82 participants (40 F, mean age: 32.5 \u00b1 11.5 years) from 11 March to 18 April 2021, when Campania was classified as a \"red zone\", i.e. it was subjected to strict restrictions, only slightly looser than those characterizing the first national lockdown (spring 2020). Although objective sleep duration and architecture appeared in the normal range, the presence of disrupted sleep was indexed by a relevant degree of sleep fragmentation (number of awakenings \u2265 1 min: 12.7 \u00b1 6.12; number of awakenings \u2265 5 min: 3.04 \u00b1 1.52), paralleled by poor subjective sleep quality (Pittsburgh Sleep Quality Index global score: 5.77 \u00b1 2.58). These data suggest that the relevant subjective sleep impairments reported during the first wave could have relied on subtle sleep disruptions that were undetected by the few objective sleep studies from the same period. Taken together with sleep data on previous phases of the pandemic, our findings show that the detrimental effects on sleep determined by the initial pandemic outbreak have not abated across the subsequent waves of contagion, and highlight the need for interventions addressing sleep health in global emergencies.", "doi": "10.1111/jsr.13519", "pmid": "34797004", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T14:05:35.775Z", "modified": "2021-11-26T14:05:35.965Z"}, {"entity": "publication", "iuid": "42a5b1f5ed414ca89ebfa2f8135b2fdf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/42a5b1f5ed414ca89ebfa2f8135b2fdf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/42a5b1f5ed414ca89ebfa2f8135b2fdf"}}, "title": "Fear of COVID-19 and Trust in the Healthcare System Mediates the Association between Individual's Risk Perception and Preventive COVID-19 Behaviours among Iranians.", "authors": [{"family": "Alijanzadeh", "given": "Mehran", "initials": "M"}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK", "orcid": "0000-0003-0530-8138", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d442447b551649d8a5372c6bf0075c91.json"}}, {"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Mahmoudi", "given": "Narges", "initials": "N"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Liu", "given": "Hsien-Kuan", "initials": "HK", "orcid": "0000-0003-0176-1381", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee8322e92e0e4d9cb5739b6fa1ac9d7f.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-11-19", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "22", "issn-l": null}, "abstract": "Problems caused by the novel coronavirus disease-2019 (COVID-19) and its mutations have brought challenges in pandemic control for all countries worldwide. The present study examines the mediating roles of fear of COVID-19 and trust in the healthcare system in the association between individual's risk perception and performing preventive COVID-19 behaviours among Iranians. A cross-sectional study design was used to collect data from 3652 residents of Qazvin province in Iran from 3 February to 15 April 2021 using a multistage stratified cluster sampling method. Participants responded to an online questionnaire concerning their fear of COVID-19, risk perception, trust in the healthcare system, and preventive COVID-19 behaviours. Small to medium positive interrelationships were observed between the variables of the study. Fear of COVID-19, trust in the healthcare system or both (fear of COVID-19 and trust in the healthcare system) mediated the association between an individual's risk perception and performing preventive COVID-19 behaviours. The study demonstrated there are at least four ways through which an individual's risk perception can influence preventive COVID-19 behaviours. Therefore, clinicians, health communicators, and researchers may capitalize on these findings to enhance preventive COVID-19 behaviours to help mitigate the spread of COVID-19 infection.", "doi": "10.3390/ijerph182212146", "pmid": "34831900", "labels": {"Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182212146"}, {"db": "pmc", "key": "PMC8621944"}], "notes": [], "created": "2021-12-18T18:16:01.936Z", "modified": "2021-12-18T18:16:02.033Z"}, {"entity": "publication", "iuid": "f645e0019835455a984c862319a6db39", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f645e0019835455a984c862319a6db39.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f645e0019835455a984c862319a6db39"}}, "title": "Clinical and hospitalisation predictors of COVID-19 in the first month of the pandemic, Portugal.", "authors": [{"family": "Perez Duque", "given": "Mariana", "initials": "M", "orcid": "0000-0001-9999-8402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6f20ad39f5c74255b07b64d6dc93f17c.json"}}, {"family": "Saad", "given": "Neil J", "initials": "NJ"}, {"family": "Lucaccioni", "given": "H\u00e9lo\u00efse", "initials": "H"}, {"family": "Costa", "given": "Cristina", "initials": "C"}, {"family": "McMahon", "given": "Geroid", "initials": "G"}, {"family": "Machado", "given": "Firmino", "initials": "F"}, {"family": "Balasegaram", "given": "Sooria", "initials": "S"}, {"family": "S\u00e1 Machado", "given": "Rita", "initials": "R"}], "type": "journal article", "published": "2021-11-19", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "11", "pages": "e0260249", "issn-l": "1932-6203"}, "abstract": "COVID-19 mainly presents as a respiratory disease with flu-like symptoms, however, recent findings suggest that non-respiratory symptoms can occur early in the infection and cluster together in different groups in different regions. We collected surveillance data among COVID-19 suspected cases tested in mainland Portugal during the first wave of the pandemic, March-April 2020. A multivariable logistic-regression analysis was performed to ascertain the effects of age, sex, prior medical condition and symptoms on the likelihood of testing positive and hospitalisation. Of 25,926 COVID-19 suspected cases included in this study, 5,298 (20%) tested positive. Symptoms were grouped into ten clusters, of which two main ones: one with cough and fever and another with the remainder. There was a higher odds of a positive test with increasing age, myalgia and headache. The odds of being hospitalised increased with age, presence of fever, dyspnoea, or having a prior medical condition although these results varied by region. Presence of cough and other respiratory symptoms did not predict COVID-19 compared to non-COVID respiratory disease patients in any region. Dyspnoea was a strong determinant of hospitalisation, as well as fever and the presence of a prior medical condition, whereas these results varied by region.", "doi": "10.1371/journal.pone.0260249", "pmid": "34797879", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-13990"}, {"db": "pmc", "key": "PMC8604361"}], "notes": [], "created": "2021-11-26T14:05:16.418Z", "modified": "2021-11-26T14:05:16.473Z"}, {"entity": "publication", "iuid": "75fa1f2465c24fa18ebf10faee384bc8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/75fa1f2465c24fa18ebf10faee384bc8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/75fa1f2465c24fa18ebf10faee384bc8"}}, "title": "COVID-19 Testing in Sweden During 2020-Split Responsibilities and Multi-Level Challenges.", "authors": [{"family": "Fredriksson", "given": "Mio", "initials": "M"}, {"family": "Hallberg", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-11-19", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "754861", "issn-l": "2296-2565"}, "abstract": "Sweden's use of soft response measures early in the COVID-19 pandemic received a good deal of international attention. Within Sweden, one of the most debated aspects of the pandemic response has been COVID-19 testing and the time it took to increase testing capacity. In this article, the development of and the debate surrounding COVID-19 testing in Sweden during 2020 is described in detail, with a particular focus on the coordination between national and regional actors in the decentralised healthcare system. A qualitative case study was carried out based on qualitative document analysis with a chronological presentation. To understand COVID-19 testing in Sweden, two aspects of its public administration model emerged as particularly important: (i) the large and independent government agencies and (ii) self-governing regions and municipalities. In addition, the responsibility principle in Swedish crisis management was crucial. Overall, the results show that mass testing was a new area for coordination and involved a number of national and regional actors with partly different views on their respective roles, responsibilities and interpretations of the laws and regulations. The description shows the ambiguities in the purpose of testing and the shortcomings in communication and cooperation during the first half of 2020, but after that an increasing consistency among the crucial actors. During the first half of 2020, testing capacity in Sweden was limited and reserved to protect the most vulnerable in society. Because mass testing for viruses is not normally carried out by the 21 self-governing regions responsible for healthcare and communicable disease prevention, and the Public Health Agency of Sweden stated that there was no medical reason to test members of the public falling ill with COVID-like symptoms, the responsibility for mass testing fell through the cracks during the first few months of the pandemic. This article thus illustrates problems associated with multi-level governance in healthcare during a crisis and illustrates the discrepancy between the health service's focus on the individual and the public health-oriented work carried out within communicable disease control.", "doi": "10.3389/fpubh.2021.754861", "pmid": "34869171", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC8639858"}], "notes": [], "created": "2021-12-12T07:09:35.537Z", "modified": "2023-07-13T11:28:19.389Z"}, {"entity": "publication", "iuid": "0c76fbcbdeaf4122ba8d9d2e761978e6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c76fbcbdeaf4122ba8d9d2e761978e6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c76fbcbdeaf4122ba8d9d2e761978e6"}}, "title": "'Who will do it if I don't?' Nurse anaesthetists' experiences of working in the intensive care unit during the COVID-19 pandemic.", "authors": [{"family": "Hallgren", "given": "Jenny", "initials": "J"}, {"family": "Larsson", "given": "Margaretha", "initials": "M"}, {"family": "Kjell\u00e9n", "given": "Malin", "initials": "M"}, {"family": "Lagerroth", "given": "David", "initials": "D"}, {"family": "B\u00e4ckstr\u00f6m", "given": "Caroline", "initials": "C"}], "type": "journal article", "published": "2021-11-19", "journal": {"title": "Aust Crit Care", "issn": "1036-7314", "issn-l": null}, "abstract": "During the COVID-19 pandemic, the workload on the intensive care unit (ICU) increased nationally in Sweden as well as globally. Certified registered nurse anaesthetists (CRNAs) in Sweden were transferred at short notice to work with seriously ill patients with COVID-19 in the ICU, which is not part of the CRNAs' specialist area. However, limited research has shed light on healthcare professionals' experiences of the pandemic.\n\nThis study illuminates CRNAs' experiences of working in the ICU during the COVID-19 pandemic.\n\nThis study used a qualitative method with an inductive approach to interview nurse anaesthetists who worked in the ICU during the COVID-19 pandemic.\n\nThe participants experienced ambivalent feelings towards their work in the ICU. They also lacked information, which created feelings of uncertainty and resulted in expectations that did not correspond to the reality. They described that owing to an inadequate introduction, they could only provide \"sufficient\" care, which in many cases caused ethical stress. Not being able to get to know their new colleagues well enough to create effective cooperation created frustration. Even though the participants experienced the work in the ICU as demanding and challenging, overall, they enjoyed their time in the ICU and were treated well by their colleagues.\n\nAlthough CRNAs cannot replace intensive care nurses, they are a useful resource in the ICU in the care of patients with COVID-19. Healthcare workers who are allocated from their ordinary units to the ICU need adequate information and support from their work managers to be able to provide the best possible care and to stay healthy themselves.", "doi": "10.1016/j.aucc.2021.11.003", "pmid": "34955333", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1036-7314(21)00171-5"}, {"db": "pmc", "key": "PMC8602969"}], "notes": [], "created": "2022-01-04T15:25:03.308Z", "modified": "2022-01-04T15:25:03.321Z"}, {"entity": "publication", "iuid": "eb87609ca02340e78b47e4023949bbcd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb87609ca02340e78b47e4023949bbcd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb87609ca02340e78b47e4023949bbcd"}}, "title": "The extent of neuroradiological findings in COVID-19 shows correlation with blood biomarkers, Glasgow coma scale score and days in intensive care.", "authors": [{"family": "F\u00e4llmar", "given": "David", "initials": "D"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ"}, {"family": "Jackmann", "given": "Sven", "initials": "S"}, {"family": "Pavel", "given": "Radu", "initials": "R"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Westman", "given": "Gabriel", "initials": "G"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Virhammar", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2021-11-18", "journal": {"title": "J Neuroradiol", "issn": "0150-9861", "issn-l": null}, "abstract": "A wide range of neuroradiological findings has been reported in patients with coronavirus disease 2019 (COVID-19), ranging from subcortical white matter changes to infarcts, haemorrhages and focal contrast media enhancement. These have been descriptively but inconsistently reported and correlations with clinical findings and biomarkers have been difficult to extract from the literature. The purpose of this study was to quantify the extents of neuroradiological findings in a cohort of patients with COVID-19 and neurological symptoms, and to investigate correlations with clinical findings, duration of intensive care and biomarkers in blood.\n\nPatients with positive SARS-CoV-2 and at least one new-onset neurological symptom were included from April until July 2020. Nineteen patients were examined regarding clinical symptoms, biomarkers in blood and MRI of the brain. In order to quantify the MRI findings, a semi-quantitative neuroradiological severity scale was constructed a priori, and applied to the MR images by two specialists in neuroradiology.\n\nThe score from the severity scale correlated significantly with blood biomarkers of CNS injury (glial fibrillary acidic protein, total-tau, ubiquitin carboxyl-terminal hydrolase L1) and inflammation (C-reactive protein), Glasgow Coma Scale score, and the number of days spent in intensive care. The underlying radiological assessments had inter-rater agreements of 90.5%/86% (for assessments with 2/3 alternatives). Total intraclass correlation was 0.80. Previously reported neuroradiological findings in COVID-19 have been diverse and heterogenous. In this study, the extent of findings in MRI examination of the brain, quantified using a structured report, shows correlation with relevant biomarkers.", "doi": "10.1016/j.neurad.2021.11.003", "pmid": "34800562", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0150-9861(21)00167-X"}, {"db": "pmc", "key": "PMC8599173"}], "notes": [], "created": "2021-11-26T14:02:06.243Z", "modified": "2021-12-10T17:54:55.138Z"}, {"entity": "publication", "iuid": "61d8c768c9ee42fb8ec88ce2408194e9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61d8c768c9ee42fb8ec88ce2408194e9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61d8c768c9ee42fb8ec88ce2408194e9"}}, "title": "Red blood cell blood group A antigen level affects the ability of heparin and PfEMP1 antibodies to disrupt Plasmodium falciparum rosettes.", "authors": [{"family": "Hedberg", "given": "Pontus", "initials": "P", "orcid": "0000-0003-3153-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd6af5accfc84ff9a81983a5ab6683aa.json"}}, {"family": "Sirel", "given": "Madle", "initials": "M"}, {"family": "Moll", "given": "Kirsten", "initials": "K"}, {"family": "Kiwuwa", "given": "Mpungu Steven", "initials": "MS"}, {"family": "H\u00f6glund", "given": "Petter", "initials": "P"}, {"family": "Ribacke", "given": "Ulf", "initials": "U"}, {"family": "Wahlgren", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2021-11-18", "journal": {"title": "Malar J", "issn": "1475-2875", "volume": "20", "issue": "1", "pages": "441", "issn-l": null}, "abstract": "The histo-blood group ABO system has been associated with adverse outcomes in COVID-19, thromboembolic diseases and Plasmodium falciparum malaria. An integral part of the severe malaria pathogenesis is rosetting, the adherence of parasite infected red blood cells (RBCs) to uninfected RBCs. Rosetting is influenced by the host's ABO blood group (Bg) and rosettes formed in BgA have previously been shown to be more resilient to disruption by heparin and shield the parasite derived surface antigens from antibodies. However, data on rosetting in weak BgA subgroups is scarce and based on investigations of relatively few donors.\n\nAn improved high-throughput flow cytometric assay was employed to investigate rosetting characteristics in an extensive panel of RBC donor samples of all four major ABO Bgs, as well as low BgA expressing samples.\n\nAll non-O Bgs shield the parasite surface antigens from strain-specific antibodies towards P. falciparum erythrocyte membrane protein 1 (PfEMP1). A positive correlation between A-antigen levels on RBCs and rosette tightness was observed, protecting the rosettes from heparin- and antibody-mediated disruption.\n\nThese results provide new insights into how the ABO Bg system affects the disease outcome and cautions against interpreting the results from the heterogeneous BgA phenotype as a single group in epidemiological and experimental studies.", "doi": "10.1186/s12936-021-03975-w", "pmid": "34794445", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12936-021-03975-w"}, {"db": "pmc", "key": "PMC8600353"}], "notes": [], "created": "2021-11-26T14:10:07.743Z", "modified": "2021-11-26T14:10:07.797Z"}, {"entity": "publication", "iuid": "701bbb9615b6499f804cebf6ab23736f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/701bbb9615b6499f804cebf6ab23736f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/701bbb9615b6499f804cebf6ab23736f"}}, "title": "Are sex disparities in COVID-19 a predictable outcome of failing men's health provision?", "authors": [{"family": "Tharakan", "given": "Tharu", "initials": "T"}, {"family": "Khoo", "given": "Christopher C", "initials": "CC", "orcid": "0000-0002-1706-2457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4577a71a676e449caa7c8f224b4da83f.json"}}, {"family": "Giwercman", "given": "Aleksander", "initials": "A"}, {"family": "Jayasena", "given": "Channa N", "initials": "CN", "orcid": "0000-0002-2578-8223", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b94255faecdd403a951cd4d854c1fb7d.json"}}, {"family": "Sofikitis", "given": "Nikolaos", "initials": "N", "orcid": "0000-0003-1528-4029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/878fcbbf78bf4f98bc7622484e44415d.json"}}, {"family": "Salonia", "given": "Andrea", "initials": "A", "orcid": "0000-0002-0595-7165", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/940b454070ba44e8ad349d3c8f6c06c3.json"}}, {"family": "Minhas", "given": "Suks", "initials": "S"}], "type": "journal article", "published": "2021-11-18", "journal": {"title": "Nat Rev Urol", "issn": "1759-4820", "issn-l": null}, "abstract": "The COVID-19 pandemic, caused by the SARS-CoV-2 coronavirus, has taken a catastrophic toll on society, health-care systems and the economy. Notably, COVID-19 has been shown to be associated with a higher mortality rate in men than in women. This disparity is likely to be a consequence of a failure to invest in men's health, as it has also been established that men have a lower life expectancy and poorer outcomes from non-communicable diseases than women. A variety of biological, social and economic factors have contributed to the sex disparities in mortality from COVID-19. A streamlined men's health programme - with the urologist as the gatekeeper of men's health - is needed to help prevent future tragedies of this nature.", "doi": "10.1038/s41585-021-00535-4", "pmid": "34795426", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41585-021-00535-4"}, {"db": "pmc", "key": "PMC8600906"}], "notes": [], "created": "2021-11-26T14:08:51.860Z", "modified": "2021-11-26T14:08:52.023Z"}, {"entity": "publication", "iuid": "d60de72901f74a45895fc2c45e98c87b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d60de72901f74a45895fc2c45e98c87b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d60de72901f74a45895fc2c45e98c87b"}}, "title": "Analyzing the Stressors for Frontline Soldiers Fighting Against Coronavirus Disease 2019 Pandemic.", "authors": [{"family": "Shaukat", "given": "Muhammad Zeeshan", "initials": "MZ"}, {"family": "Scholz", "given": "Miklas", "initials": "M"}, {"family": "Qazi", "given": "Tehmina Fiaz", "initials": "TF"}, {"family": "Niazi", "given": "Abdul Aziz Khan", "initials": "AAK"}, {"family": "Basit", "given": "Abdul", "initials": "A"}, {"family": "Mahmood", "given": "Asif", "initials": "A"}], "type": "journal article", "published": "2021-11-18", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "751882", "issn-l": "1664-1078"}, "abstract": "This study aimed to analyze stressors to which medical staff is vulnerable due to the coronavirus disease 2019 (COVID-19) pandemic. It also imposes a hierarchy on complex relations among stressors for excavating underlying structure and builds a model of interrelationships contrasting reality. The design of this study comprises a literature survey, data collection from primary sources, and analysis. Stressors have been explored from within current published/unpublished literature and validated by experts through approval vote. Data were collected from the focus group (panel of experts), and interpretive structural modeling (ISM) was used as the research methodology. Findings of ISM are avowed through \"cross-impact matrix multiplication applied to classification\" (MICMAC) analysis. As a result of the literature survey, a list of stressors was generated, and a total of 19 stressors qualified as representative of the phenomenon. The results of ISM show that two stressors (i.e., \"unavailability of proper personal protective equipment (PPE)\" and \"lack of proper communication\") emerged as the most critical stressors since they occupy the bottom of the model, whereas, four stressors (i.e., \"anxious about isolation/quarantine,\" \"subject to violent crimes,\" \"feeling frustrated and powerless,\" and \"exhausting shifts/hours without clear end\") are relatively less critical since they occupy the top of the model. The rest of the stressors occupy the middle of the model and therefore, have moderate-severe effects on frontline soldiers. The results of MICMAC show that the stressor \"subject to violent crimes\" is classified in the dependent cluster and the remaining fall in the linkage cluster but no stressor falls in independent and autonomous. Overall results indicate that all stressors are relevant to the phenomenon under this study, but they are currently not settled. This study is invaluable for policymakers, frontline soldiers, researchers, the international community, and society since it provides a lot of new information that is helpful in refining strategies and combating influential stressors.", "doi": "10.3389/fpsyg.2021.751882", "pmid": "34867641", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8636429"}], "notes": [], "created": "2021-12-12T07:07:18.693Z", "modified": "2021-12-12T07:07:36.228Z"}, {"entity": "publication", "iuid": "18e86ad4da7e436aacdfe11da55bc5f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18e86ad4da7e436aacdfe11da55bc5f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18e86ad4da7e436aacdfe11da55bc5f1"}}, "title": "Obstructive sleep apnea is an independent risk factor for severe COVID-19: a population-based study.", "authors": [{"family": "R\u00f6gnvaldsson", "given": "Kristj\u00e1n Godsk", "initials": "KG"}, {"family": "Ey\u00fe\u00f3rsson", "given": "El\u00edas S\u00e6bj\u00f6rn", "initials": "ES"}, {"family": "Emilsson", "given": "\u00d6ssur Ingi", "initials": "\u00d6I"}, {"family": "Eysteinsd\u00f3ttir", "given": "Bj\u00f6rg", "initials": "B"}, {"family": "P\u00e1lsson", "given": "Run\u00f3lfur", "initials": "R"}, {"family": "Gottfre\u00f0sson", "given": "Magn\u00fas", "initials": "M"}, {"family": "Gu\u00f0mundsson", "given": "Gunnar", "initials": "G"}, {"family": "Steingr\u00edmsson", "given": "Vilhj\u00e1lmur", "initials": "V"}], "type": "journal article", "published": "2021-11-17", "journal": {"title": "Sleep", "issn": "1550-9109", "issn-l": null}, "abstract": "Obstructive sleep apnea (OSA) has been proposed as a risk factor for severe COVID-19. Confounding is an important consideration as OSA is associated with several known risk factors for severe COVID-19. Our aim was to assess the association of OSA with hospitalization due to COVID-19 using a population-based cohort with detailed information on OSA and comorbidities.\n\nIncluded were all community-dwelling Icelandic citizens 18 years of age and older diagnosed with SARS-CoV-2 infection in 2020. Data on demographics, comorbidities, and outcomes of COVID-19 was obtained from centralized national registries. Diagnosis of OSA was retrieved from the centralized Sleep Department Registry at Landspitali-The National University Hospital. Severe COVID-19 was defined as the composite outcome of hospitalization and death. The associations between OSA and the outcome were expressed as odds ratios (OR) with 95% confidence intervals (95% CI), calculated using logistic regression models and inverse probability weighting.\n\nA total of 4,756 individuals diagnosed with SARS-CoV-2 infection in Iceland were included in the study (1.3% of the Icelandic population), of whom 185 had a diagnosis of OSA. In total, 238 were hospitalized or died, 38 of whom had OSA. Adjusted for age, sex, and BMI, OSA was associated with poor outcome (OR 2.2, 95% CI 1.4 -3.5). This association was slightly attenuated (OR 2.0, 95% CI 2.0, 1.2-3.2) when adjusted for demographic characteristics and various comorbidities.\n\nOSA was associated with twofold increase in risk of severe COVID-19, and the association was not explained by obesity or other comorbidities.", "doi": "10.1093/sleep/zsab272", "pmid": "34791469", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6430441"}], "notes": [], "created": "2021-11-26T14:10:27.773Z", "modified": "2021-11-26T14:10:27.786Z"}, {"entity": "publication", "iuid": "2db2e9c0e8964a27b948c7c2d484f5bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2db2e9c0e8964a27b948c7c2d484f5bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2db2e9c0e8964a27b948c7c2d484f5bf"}}, "title": "Impact of the Double Mutants on Spike Protein of SARS-CoV-2 B.1.617 Lineage on the Human ACE2 Receptor Binding: A Structural Insight.", "authors": [{"family": "Khan", "given": "Mohd Imran", "initials": "MI"}, {"family": "Baig", "given": "Mohammad Hassan", "initials": "MH", "orcid": "0000-0001-8227-4838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1fe7992c2c94f768b7b8d781c99c618.json"}}, {"family": "Mondal", "given": "Tanmoy", "initials": "T"}, {"family": "Alorabi", "given": "Mohammed", "initials": "M", "orcid": "0000-0002-4326-6066", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab180e94a4ae4dcf99c5f8ae79697e44.json"}}, {"family": "Sharma", "given": "Tanuj", "initials": "T"}, {"family": "Dong", "given": "Jae-June", "initials": "JJ", "orcid": "0000-0002-2420-2155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0de75e6c65df43d9a886bf95063d625a.json"}}, {"family": "Cho", "given": "Jae Yong", "initials": "JY"}], "type": "journal article", "published": "2021-11-17", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "11", "issn-l": "1999-4915"}, "abstract": "The recent emergence of novel SARS-CoV-2 variants has threatened the efforts to contain the COVID-19 pandemic. The emergence of these \"variants of concern\" has increased immune escape and has supplanted the ancestral strains. The novel variants harbored by the B.1.617 lineage (kappa and delta) carry mutations within the receptor-binding domain of spike (S) protein (L452R + E484Q and L452R + T478K), the region binding to the host receptor. The double mutations carried by these novel variants are primarily responsible for an upsurge number of COVID-19 cases in India. In this study, we thoroughly investigated the impact of these double mutations on the binding capability to the human host receptor. We performed several structural analyses and found that the studied double mutations increase the binding affinity of the spike protein to the human host receptor (ACE2). Furthermore, our study showed that these double mutants might be a dominant contributor enhancing the receptor-binding affinity of SARS-CoV-2 and consequently making it more stable. We also investigated the impact of these mutations on the binding affinity of two monoclonal antibodies (Abs) (2-15 and LY-CoV555) and found that the presence of the double mutations also hinders its binding with the studied Abs. The principal component analysis, free energy landscape, intermolecular interaction, and other investigations provided a deeper structural insight to better understand the molecular mechanism responsible for increased viral transmissibility of these variants.", "doi": "10.3390/v13112295", "pmid": "34835101", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "v13112295"}, {"db": "pmc", "key": "PMC8625741"}], "notes": [], "created": "2021-12-18T18:14:46.920Z", "modified": "2021-12-18T18:14:47.044Z"}, {"entity": "publication", "iuid": "6f4adb0b60cf45539307221b47720cde", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f4adb0b60cf45539307221b47720cde.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f4adb0b60cf45539307221b47720cde"}}, "title": "Impact of COVID-19 on global burn care.", "authors": [{"family": "Laura", "given": "Pompermaier", "initials": "P"}, {"family": "Jos\u00e9", "given": "Adorno", "initials": "A"}, {"family": "Nikki", "given": "Allorto", "initials": "A"}, {"family": "Khaled", "given": "Altarrah", "initials": "A"}, {"family": "Barret", "given": "Juan P", "initials": "JP"}, {"family": "Jeffery", "given": "Carter", "initials": "C"}, {"family": "Shobha", "given": "Chamania", "initials": "C"}, {"family": "Jack", "given": "Chong Si", "initials": "CS"}, {"family": "Scott", "given": "Corlew", "initials": "C"}, {"family": "Nadia", "given": "Depetris", "initials": "D"}, {"family": "Moustafa", "given": "Elmasry", "initials": "E"}, {"family": "Liao", "given": "Junlin", "initials": "J"}, {"family": "Josef", "given": "Haik", "initials": "H"}, {"family": "Briana", "given": "Horwath", "initials": "H"}, {"family": "Sunil", "given": "Keswani", "initials": "K"}, {"family": "Tetsuro", "given": "Kiyozumi", "initials": "K"}, {"family": "Jorge", "given": "Leon-Villapalos", "initials": "LV"}, {"family": "Gaoxing", "given": "Luo", "initials": "L"}, {"family": "Hajime", "given": "Matsumura", "initials": "M"}, {"family": "Ariel", "given": "Miranda-Altamirano", "initials": "MA"}, {"family": "Naiem", "given": "Moiemen", "initials": "M"}, {"family": "Kiran", "given": "Nakarmi", "initials": "N"}, {"family": "Nawar", "given": "Ahmed", "initials": "A"}, {"family": "Faustin", "given": "Ntirenganya", "initials": "N"}, {"family": "Anthony", "given": "Olekwu", "initials": "O"}, {"family": "Tom", "given": "Potokar", "initials": "P"}, {"family": "Liang", "given": "Qiao", "initials": "Q"}, {"family": "Man", "given": "Rai Shankar", "initials": "RS"}, {"family": "Ingrid", "given": "Steinvall", "initials": "S"}, {"family": "Ahmed", "given": "Tanveer", "initials": "T"}, {"family": "Molina", "given": "Vana Luiz Philipe", "initials": "VLP"}, {"family": "Shelley", "given": "Wall", "initials": "W"}, {"family": "Mark", "given": "Fisher", "initials": "F"}], "type": "journal article", "published": "2021-11-17", "journal": {"title": "Burns", "issn": "1879-1409", "issn-l": null}, "abstract": "Worldwide, different strategies have been chosen to face the COVID-19-patient surge, often affecting access to health care for other patients. This observational study aimed to investigate whether the standard of burn care changed globally during the pandemic, and whether country\u00b4s income, geographical location, COVID-19-transmission pattern, and levels of specialization of the burn units affected reallocation of resources and access to burn care.\n\nThe Burn Care Survey is a questionnaire developed to collect information on the capacity to provide burn care by burn units around the world, before and during the pandemic. The survey was distributed between September and October 2020. McNemar`s test analyzed differences between services provided before and during the pandemic, \u03c72 or Fisher's exact test differences between groups. Multivariable logistic regression analyzed the independent effect of different factors on keeping the burn units open during the pandemic.\n\nThe survey was completed by 234 burn units in 43 countries. During the pandemic, presence of burn surgeons did not change (p = 0.06), while that of anesthetists and dedicated nursing staff was reduced (<0.01), and so did the capacity to manage patients in all age groups (p = 0.04). Use of telemedicine was implemented (p < 0.01), collaboration between burn centers was not. Burn units in LMICs and LICs were more likely to be closed, after adjustment for other factors.\n\nDuring the pandemic, most burn units were open, although availability of standard resources diminished worldwide. The use of telemedicine increased, suggesting the implementation of new strategies to manage burns. Low income was independently associated with reduced access to burn care.", "doi": "10.1016/j.burns.2021.11.010", "pmid": "34903416", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0305-4179(21)00312-0"}, {"db": "pmc", "key": "PMC8664090"}], "notes": [], "created": "2021-12-18T17:59:08.739Z", "modified": "2021-12-18T17:59:08.775Z"}, {"entity": "publication", "iuid": "9bd7f6ad9b65462e99a211e5e7ebbfbb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9bd7f6ad9b65462e99a211e5e7ebbfbb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9bd7f6ad9b65462e99a211e5e7ebbfbb"}}, "title": "Duration of SARS-CoV-2 viremia and its correlation to mortality and inflammatory parameters in patients hospitalized for COVID-19: a cohort study.", "authors": [{"family": "Hagman", "given": "Karl", "initials": "K"}, {"family": "Hedenstierna", "given": "Magnus", "initials": "M"}, {"family": "Rudling", "given": "Johan", "initials": "J"}, {"family": "Gille-Johnson", "given": "Patrik", "initials": "P"}, {"family": "Hammas", "given": "Berit", "initials": "B"}, {"family": "Grabbe", "given": "Malin", "initials": "M"}, {"family": "Jakobsson", "given": "Jan", "initials": "J"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Ursing", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2021-11-17", "journal": {"title": "Diagn Microbiol Infect Dis", "issn": "1879-0070", "volume": "102", "issue": "3", "pages": "115595", "issn-l": null}, "abstract": "SARS-CoV-2 viremia at admission is associated with high risk for mortality. However, longitudinal data on viremia duration are limited. Viremic patients hospitalized for COVID-19 were included in a cohort. Time to serum viral clearance and the effect of viremia duration on the odds of mortality were calculated. One hundred and twenty-one viremic patients were included. Median age was 62 (IQR 52-71) years and 68% were males. The total in-hospital mortality of the cohort was 33%. Median time from admission to serum viral clearance was 7 (95% CI 6-8) days. Duration of viremia showed a relative risk ratio of 1.40 (95% CI 1.02-1.92) for the odds of mortality in an adjusted multinomial logistic regression. Serum viral clearance coincided with defervescence and decreasing C-reactive protein. Median time to serum viral clearance was 7 days after admission. The odds of mortality increased with 40% for each additional day of viremia.", "doi": "10.1016/j.diagmicrobio.2021.115595", "pmid": "34896666", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0732-8893(21)00286-8"}, {"db": "pmc", "key": "PMC8595972"}], "notes": [], "created": "2021-12-18T18:00:53.948Z", "modified": "2021-12-18T18:00:53.984Z"}, {"entity": "publication", "iuid": "e4bfeb90baee400ea2e8bdf13019a27d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e4bfeb90baee400ea2e8bdf13019a27d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e4bfeb90baee400ea2e8bdf13019a27d"}}, "title": "Critical care nurses' experiences of working during the first phase of the COVID-19 pandemic - Applying the Person-centred Practice Framework.", "authors": [{"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Nordin", "given": "Anna", "initials": "A"}, {"family": "Engstr\u00f6m", "given": "\u00c5sa", "initials": "\u00c5"}], "type": "journal article", "published": "2021-11-17", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "pages": "103179", "issn-l": null}, "abstract": "The aim of the study was to deductively study person-centred care, based on critical care nurses' experiences during the first phase of the CoViD-19 pandemic.\n\nThe study used a qualitative design.\n\nData collection was conducted as individual interviews and was analysed with qualitative content analysis with a deductive approach.\n\nSix critical care nurses working in a special CoViD-19 intensive care unit during the first phase of the pandemic participated.\n\nThe findings are presented within the four domains of person-centred practice: the prerequisites, the care environment, person-centred processes and person-centred outcomes. While the ambition and knowledge about how to work in accordance with person-centred practice were high, there were several obstacles to perform it.\n\nWe need to prepare ahead of time so that nurses have optimal organisational prerequisites to be able to work in accordance with person-centred practice, also during pandemics and other crisis, which means to be able to give nursing care in accordance with the ill person's needs and resources.", "doi": "10.1016/j.iccn.2021.103179", "pmid": "34895797", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(21)00168-3"}, {"db": "pmc", "key": "PMC8595352"}], "notes": [], "created": "2021-12-18T18:02:17.054Z", "modified": "2021-12-18T18:02:17.065Z"}, {"entity": "publication", "iuid": "3a3a2ac661554126906792aff64d19e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a3a2ac661554126906792aff64d19e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a3a2ac661554126906792aff64d19e2"}}, "title": "Flow as a Key Predictor of Subjective Well-Being Among Chinese University Students: A Chain Mediating Model.", "authors": [{"family": "Wu", "given": "Jun", "initials": "J"}, {"family": "Xie", "given": "Mei", "initials": "M"}, {"family": "Lai", "given": "Yao", "initials": "Y"}, {"family": "Mao", "given": "Yanhui", "initials": "Y"}, {"family": "Harmat", "given": "Laszlo", "initials": "L"}], "type": "journal article", "published": "2021-11-16", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "743906", "issn-l": "1664-1078"}, "abstract": "The present study investigated a conceptual model by testing flow experience and subjective well-being of university students during Coronavirus Diseas-19 (COVID-19) via considering their underlying mechanisms of academic self-efficacy and self-esteem. A total of 1,109 Chinese university students completed a questionnaire containing scales of subjective well-being, flow, academic self-efficacy, and self-esteem. Results yielded from the structural equation modeling analysis indicated a significant and positive association between flow experience and subjective well-being, and such an association was sequentially mediated by academic self-efficacy and self-esteem. Findings also provided empirical evidence for the proposed model highlighting the significant role of flow experience at the higher educational context in predicting subjective well-being of Chinese university students, and how such a relation can be supported by suggested mediating roles academic self-efficacy and self-esteem played.", "doi": "10.3389/fpsyg.2021.743906", "pmid": "34867624", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8636857"}], "notes": [], "created": "2021-12-12T07:06:54.204Z", "modified": "2021-12-12T07:06:54.218Z"}, {"entity": "publication", "iuid": "886aeb7ea151492486db7977a020afe9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/886aeb7ea151492486db7977a020afe9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/886aeb7ea151492486db7977a020afe9"}}, "title": "COVID-19 and risk of subsequent life-threatening secondary infections: a matched cohort study in UK Biobank.", "authors": [{"family": "Hou", "given": "Can", "initials": "C"}, {"family": "Hu", "given": "Yihan", "initials": "Y"}, {"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Chen", "given": "Wenwen", "initials": "W"}, {"family": "Zeng", "given": "Yu", "initials": "Y"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Sun", "given": "Yajing", "initials": "Y"}, {"family": "Qu", "given": "Yuanyuan", "initials": "Y"}, {"family": "Gottfre\u00f0sson", "given": "Magn\u00fas", "initials": "M"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "journal article", "published": "2021-11-16", "journal": {"title": "BMC Med", "issn": "1741-7015", "volume": "19", "issue": "1", "pages": "301", "issn-l": null}, "abstract": "With the increasing number of people infected with and recovered from coronavirus disease 2019 (COVID-19), the extent of major health consequences of COVID-19 is unclear, including risks of severe secondary infections.\n\nBased on 445,845 UK Biobank participants registered in England, we conducted a matched cohort study where 5151 individuals with a positive test result or hospitalized with a diagnosis of COVID-19 were included in the exposed group. We then randomly selected up to 10 matched individuals without COVID-19 diagnosis for each exposed individual (n = 51,402). The life-threatening secondary infections were defined as diagnoses of severe secondary infections with high mortality rates (i.e., sepsis, endocarditis, and central nervous system infections) from the UK Biobank inpatient hospital data, or deaths from these infections from mortality data. The follow-up period was limited to 3 months after the initial COVID-19 diagnosis. Using a similar study design, we additionally constructed a matched cohort where exposed individuals were diagnosed with seasonal influenza from either inpatient hospital or primary care data between 2010 and 2019 (6169 exposed and 61,555 unexposed individuals). After controlling for multiple confounders, Cox models were used to estimate hazard ratios (HRs) of life-threatening secondary infections after COVID-19 or seasonal influenza.\n\nIn the matched cohort for COVID-19, 50.22% of participants were male, and the median age at the index date was 66 years. During a median follow-up of 12.71 weeks, the incidence rate of life-threatening secondary infections was 2.23 (123/55.15) and 0.25 (151/600.55) per 1000 person-weeks for all patients with COVID-19 and their matched individuals, respectively, which corresponded to a fully adjusted HR of 8.19 (95% confidence interval [CI] 6.33-10.59). The corresponding HR of life-threatening secondary infections among all patients with seasonal influenza diagnosis was 4.50, 95% CI 3.34-6.08 (p for difference < 0.01). Also, elevated HRs were observed among hospitalized individuals for life-threatening secondary infections following hospital discharge, both in the COVID-19 (HR = 6.28 [95% CI 4.05-9.75]) and seasonal influenza (6.01 [95% CI 3.53-10.26], p for difference = 0.902) cohorts.\n\nCOVID-19 patients have increased subsequent risks of life-threatening secondary infections, to an equal extent or beyond risk elevations observed for patients with seasonal influenza.", "doi": "10.1186/s12916-021-02177-0", "pmid": "34781951", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12916-021-02177-0"}, {"db": "pmc", "key": "PMC8592806"}], "notes": [], "created": "2021-11-26T14:12:01.306Z", "modified": "2021-11-26T14:12:01.341Z"}, {"entity": "publication", "iuid": "ba2274ccc726426ea87ac013ad38e11c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ba2274ccc726426ea87ac013ad38e11c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ba2274ccc726426ea87ac013ad38e11c"}}, "title": "Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models.", "authors": [{"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Mandolesi", "given": "Marco", "initials": "M"}, {"family": "Urgard", "given": "Egon", "initials": "E"}, {"family": "Kim", "given": "Changil", "initials": "C"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Perez Vidakovics", "given": "Laura", "initials": "L"}, {"family": "Pankow", "given": "Alec", "initials": "A"}, {"family": "Smith", "given": "Natalie L", "initials": "NL"}, {"family": "Castro Dopico", "given": "Xaquin", "initials": "X"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}, {"family": "Coquet", "given": "Jonathan M", "initials": "JM"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Murrell", "given": "Ben", "initials": "B"}], "type": "journal article", "published": "2021-11-16", "journal": {"title": "Cell Rep Med", "issn": "2666-3791", "issn-l": "2666-3791", "volume": "2", "issue": "11", "pages": "100450"}, "abstract": "Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) with resistance to neutralizing antibodies are threatening to undermine vaccine efficacy. Vaccination and infection have led to widespread humoral immunity against the pandemic founder (Wu-Hu-1). Against this background, it is critical to assess the outcomes of subsequent immunization with variant antigens. It is not yet clear whether heterotypic boosts would be compromised by original antigenic sin, where pre-existing responses to a prior variant dampen responses to a new one, or whether the memory B cell repertoire would bridge the gap between Wu-Hu-1 and VOCs. We show, in macaques immunized with Wu-Hu-1 spike, that a single dose of adjuvanted beta variant receptor binding domain (RBD) protein broadens neutralizing antibody responses to heterologous VOCs. Passive transfer of plasma sampled after Wu-Hu-1 spike immunization only partially protects K18-hACE2 mice from lethal challenge with a beta variant isolate, whereas plasma sampled following heterotypic RBD boost protects completely against disease.", "doi": "10.1016/j.xcrm.2021.100450", "pmid": "34723224", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Funder: VR": null, "Category: Genomics & transcriptomics": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "S2666-3791(21)00318-9"}, {"db": "pmc", "key": "PMC8536561"}, {"db": "URL", "key": "https://github.com/MurrellGroup/VOCfreq", "description": "Code used for analyses"}], "notes": [], "created": "2021-11-02T15:33:54.198Z", "modified": "2021-11-18T13:48:31.567Z"}, {"entity": "publication", "iuid": "3828890895b942c8bd11d40e982ecb75", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3828890895b942c8bd11d40e982ecb75.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3828890895b942c8bd11d40e982ecb75"}}, "title": "Predicting Work-Life Conflict: Types and Levels of Enacted and Preferred Work-Nonwork Boundary (In)Congruence and Perceived Boundary Control.", "authors": [{"family": "Mellner", "given": "Christin", "initials": "C"}, {"family": "Peters", "given": "Pascale", "initials": "P"}, {"family": "Dragt", "given": "Maria Johanna", "initials": "MJ"}, {"family": "Toivanen", "given": "Susanna", "initials": "S"}], "type": "journal article", "published": "2021-11-15", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "772537", "issn-l": "1664-1078"}, "abstract": "In 2020, everyday life changed dramatically for employees worldwide as a result of the outbreak of the Covid-19 pandemic, where an estimated 558 million employees started working from home. The pandemic, therefore, marks a fundamental shift of individuals' work-nonwork boundaries, which can impact work-life conflict. In particular, the interplay between individuals' enacted boundaries (degree to which they separate/segment or blend/integrate work-nonwork), preferred boundaries (degree of preferred segmentation or integration of work-nonwork), and perceived control over work-nonwork boundaries, may relate to work-life conflict. This study, the first to the best of our knowledge, examines whether different types and levels of work-nonwork boundary (in)congruence matter for work-life conflict, and whether perceived boundary control moderates these relationships. Boundary (in)congruence represents the degree of (mis)fit between enacted and preferred segmentation or integration. Several types of (in)congruence are distinguished: \"segmentation congruence\" (enacting and preferring segmentation); \"integration congruence\" (enacting and preferring integration); \"intrusion\" (enacting integration but preferring segmentation) and \"distance\" (enacting segmentation but preferring integration). Data from 1,229 managers working in public and private organizations in Sweden was analyzed using polynomial regression analysis with response surface modeling and moderation analysis in SPSS Process. Findings showed that \"integration congruence\" was related with higher work-life conflict than \"segmentation congruence.\" Moreover, a U-shaped relationship between incongruence and work-life conflict was found: the more incongruence, the more work-life conflict. Specifically, \"intrusion\" was related to higher work-life conflict than \"distance.\" Finally, boundary control mitigated the effect of incongruence (especially \"intrusion\") on work-life conflict. From our findings, we may conclude that work-life conflict is impacted differently depending on the type and level of boundary (in)congruence. Particularly enacted and/or preferred integration may be problematic when it comes to work-life conflict, rather than just (in)congruence per se. Moreover, boundary control can be viewed as a key factor in combating work-life conflict, especially among individuals who enact integration, but prefer segmentation. Taken together, our study contributes new and substantial knowledge by showing the importance for research and HRM-policies that take into account different types and levels of boundary (in)congruence, as these are associated with different levels of work-life conflict, which, in turn, are moderated by boundary control.", "doi": "10.3389/fpsyg.2021.772537", "pmid": "34867680", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8636054"}], "notes": [], "created": "2021-12-12T07:08:00.780Z", "modified": "2021-12-12T07:08:00.794Z"}, {"entity": "publication", "iuid": "634ab65b283f4ad5ad0e20b5d53623ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/634ab65b283f4ad5ad0e20b5d53623ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/634ab65b283f4ad5ad0e20b5d53623ef"}}, "title": "Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know?", "authors": [{"family": "Bisaccia", "given": "Giandomenico", "initials": "G", "orcid": "0000-0003-4606-3093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9ff7c6f9a724caea1cae5493f4951af.json"}}, {"family": "Ricci", "given": "Fabrizio", "initials": "F", "orcid": "0000-0002-1401-6623", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1dab56ecc21e43909dcc6881ffef5892.json"}}, {"family": "Recce", "given": "Vittoria", "initials": "V"}, {"family": "Serio", "given": "Antonio", "initials": "A"}, {"family": "Iannetti", "given": "Giovanni", "initials": "G"}, {"family": "Chahal", "given": "Anwar A", "initials": "AA", "orcid": "0000-0001-7825-8827", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/792261f66ef641ab8f135eb75586ff38.json"}}, {"family": "St\u00e5hlberg", "given": "Marcus", "initials": "M"}, {"family": "Khanji", "given": "Mohammed Yunus", "initials": "MY"}, {"family": "Fedorowski", "given": "Artur", "initials": "A", "orcid": "0000-0002-5352-6327", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2ef9375bfba4311868834aec838c8a3.json"}}, {"family": "Gallina", "given": "Sabina", "initials": "S"}], "type": "journal article", "published": "2021-11-15", "journal": {"title": "J Cardiovasc Dev Dis", "issn": "2308-3425", "volume": "8", "issue": "11", "issn-l": null}, "abstract": "Post-acute sequelae of SARS-CoV-2 (PASC), or long COVID syndrome, is emerging as a major health issue in patients with previous SARS-CoV-2 infection. Symptoms commonly experienced by patients include fatigue, palpitations, chest pain, dyspnea, reduced exercise tolerance, and \"brain fog\". Additionally, symptoms of orthostatic intolerance and syncope suggest the involvement of the autonomic nervous system. Signs of cardiovascular autonomic dysfunction appear to be common in PASC and are similar to those observed in postural orthostatic tachycardia syndrome and inappropriate sinus tachycardia. In this review, we report on the epidemiology of PASC, discuss current evidence and possible mechanisms underpinning the dysregulation of the autonomic nervous system, and suggest nonpharmacological and pharmacological interventions to treat and relieve symptoms of PASC-associated dysautonomia.", "doi": "10.3390/jcdd8110156", "pmid": "34821709", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jcdd8110156"}, {"db": "pmc", "key": "PMC8621226"}], "notes": [], "created": "2021-11-26T13:04:49.442Z", "modified": "2021-12-18T18:20:39.207Z"}, {"entity": "publication", "iuid": "85651f060d974f45a6b00cb2151928c8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/85651f060d974f45a6b00cb2151928c8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/85651f060d974f45a6b00cb2151928c8"}}, "title": "COVID-19 water, sanitation, and hygiene response: Review of measures and initiatives adopted by governments, regulators, utilities, and other stakeholders in 84 countries.", "authors": [{"family": "Gin\u00e9-Garriga", "given": "Ricard", "initials": "R"}, {"family": "Delepiere", "given": "Antoine", "initials": "A"}, {"family": "Ward", "given": "Robin", "initials": "R"}, {"family": "Alvarez-Sala", "given": "Jorge", "initials": "J"}, {"family": "Alvarez-Murillo", "given": "Isabel", "initials": "I"}, {"family": "Mariezcurrena", "given": "Virginia", "initials": "V"}, {"family": "Sandberg", "given": "Henning G\u00f6ransson", "initials": "HG"}, {"family": "Saikia", "given": "Panchali", "initials": "P"}, {"family": "Avello", "given": "Pilar", "initials": "P"}, {"family": "Thakar", "given": "Kanika", "initials": "K"}, {"family": "Ibrahim", "given": "Esmaeil", "initials": "E"}, {"family": "Nouvellon", "given": "Alban", "initials": "A"}, {"family": "El Hattab", "given": "Omar", "initials": "O"}, {"family": "Hutton", "given": "Guy", "initials": "G"}, {"family": "Jim\u00e9nez", "given": "Alejandro", "initials": "A"}], "type": "journal article", "published": "2021-11-15", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "issn-l": "0048-9697", "volume": "795", "issue": null, "pages": "148789"}, "abstract": "The COVID-19 pandemic has shone a light on handwashing as an inexpensive, widely applicable response measure. In consequence, most governments have taken action to promote access to water and sanitation services for all. This paper documents an overview of initiatives and interventions that countries have implemented during the first months of the COVID-19 response. Initiatives have been identified across 84 countries worldwide, and categorized into those that aimed at securing water, sanitation, and hygiene (WASH) for all, and those that sought to provide technical and financial support to service providers. The pandemic has not hit countries in the same way. Accordingly, results show disparities in the response between and within regions, with the level of activity found in the countries varying largely in terms of ambition and scope. Hygiene promotion and infection prevention and control (IPC) has been widely adopted - at least one response measure found in 94% of mapped countries -, although not always matched in ambition with the assured availability of soap, water, and handwashing facilities. Support to vulnerable households to promote basic access to WASH services at scale was weak (38% of countries) or implemented locally (25%), and requiring additional focus, particularly in rural areas and small towns. In addition, parallel support needs to be extended to service providers or to households themselves in the form of cash transfers, in order to ensure the financial viability and the continuity of services. All lessons learned distilled from the pandemic should help strengthen the enabling environment for more resilient services in future emergencies. Areas for focus could include developing specific pandemic response strategies and plans; strengthening coordination; and establishing emergency financial support mechanisms for water operators, for example. Overall, findings presented herein contribute to enhance current and future pandemics prevention, mitigation, and recovery.", "doi": "10.1016/j.scitotenv.2021.148789", "pmid": "34243010", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(21)03861-4"}, {"db": "pmc", "key": "PMC8254381"}], "notes": [], "created": "2021-08-06T07:57:24.602Z", "modified": "2021-09-20T16:23:07.056Z"}, {"entity": "publication", "iuid": "3e7419528ada4d74b76965da0815779b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3e7419528ada4d74b76965da0815779b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3e7419528ada4d74b76965da0815779b"}}, "title": "COVID-19 vaccination in autoimmune disease (COVAD) survey protocol.", "authors": [{"family": "Sen", "given": "Parikshit", "initials": "P", "orcid": "0000-0002-1630-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff836e2bb8e48ba8d60d7f5cc415507.json"}}, {"family": "Gupta", "given": "Latika", "initials": "L", "orcid": "0000-0003-2753-2990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c0d9fa99d9a47568ea15f7a1645ca3a.json"}}, {"family": "Lilleker", "given": "James B", "initials": "JB", "orcid": "0000-0002-9230-4137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/525a36a397c94de5899df2c41d8cc31a.json"}}, {"family": "Aggarwal", "given": "Vishwesh", "initials": "V", "orcid": "0000-0002-0986-8354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2e6226ae5e7427fbf52e180dd14e28f.json"}}, {"family": "Kardes", "given": "Sinan", "initials": "S", "orcid": "0000-0002-6311-8634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2900c3ca00da476a8914574384a3c9c2.json"}}, {"family": "Milchert", "given": "Marcin", "initials": "M", "orcid": "0000-0002-0943-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43afbcf5491b4cd9b18e74f31c0d7408.json"}}, {"family": "Gheita", "given": "Tamer", "initials": "T", "orcid": "0000-0002-1155-9729", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8ba14e3006a457b9d4fd8f5c53bf865.json"}}, {"family": "Salim", "given": "Babur", "initials": "B", "orcid": "0000-0001-8430-9299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc301a18c77c494997ef8a89a92eecde.json"}}, {"family": "Velikova", "given": "Tsvetelina", "initials": "T", "orcid": "0000-0002-0593-1272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29d2a156981843a091b85b60ff7946d6.json"}}, {"family": "Gracia-Ramos", "given": "Abraham Edgar", "initials": "AE", "orcid": "0000-0003-1842-2554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9b65643371d4b99a8d1edf8e39aa456.json"}}, {"family": "Parodis", "given": "Ioannis", "initials": "I", "orcid": "0000-0002-4875-5395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18482612245943ceb9dc97a1cc1ec38e.json"}}, {"family": "O'Callaghan", "given": "Albert Selva", "initials": "AS", "orcid": "0000-0003-2823-9761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef3e202c049b44a2a5e045bac90a393a.json"}}, {"family": "Nikiphorou", "given": "Elena", "initials": "E", "orcid": "0000-0001-6847-3726", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975093bc6bb741b1ab4fbbe45dc24d2c.json"}}, {"family": "Tan", "given": "Ai Lyn", "initials": "AL", "orcid": "0000-0002-9158-7243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65c42afe334b43e6b6deabf16b492201.json"}}, {"family": "Cavagna", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa352f27b1684e9cb69b3b41f385d754.json"}}, {"family": "Saavedra", "given": "Miguel A", "initials": "MA", "orcid": "0000-0003-0687-9944", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/706fe86e64514da380f70376cb712d44.json"}}, {"family": "Shinjo", "given": "Samuel Katsuyuki", "initials": "SK", "orcid": "0000-0002-3682-4517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/769ebafe12f0440890440787f9b200ed.json"}}, {"family": "Ziade", "given": "Nelly", "initials": "N", "orcid": "0000-0002-4479-7678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6051e9767de4359874f0c092b70ae1a.json"}}, {"family": "Knitza", "given": "Johannes", "initials": "J", "orcid": "0000-0001-9695-0657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74e7dc1cc4234009a749c4ba4f8c907d.json"}}, {"family": "Kuwana", "given": "Masataka", "initials": "M", "orcid": "0000-0001-8352-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82fb960690fa463c8db61566c2033540.json"}}, {"family": "Cagnotto", "given": "Giovanni", "initials": "G", "orcid": "0000-0002-1682-8158", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91574e9defd848a78539eabd351940c1.json"}}, {"family": "Nune", "given": "Arvind", "initials": "A", "orcid": "0000-0002-3849-614X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb816ced68f4deda152083ea4ce56e6.json"}}, {"family": "Distler", "given": "Oliver", "initials": "O", "orcid": "0000-0002-0546-8310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6576459974746968625c528f5253294.json"}}, {"family": "Chinoy", "given": "Hector", "initials": "H", "orcid": "0000-0001-6492-1288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5cbb861e1484cfb9da9dd43fbe5ee94.json"}}, {"family": "Aggarwal", "given": "Vikas", "initials": "V", "orcid": "0000-0002-2089-027X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31cc5ee9caf34d889e61e31520b4399b.json"}}, {"family": "Aggarwal", "given": "Rohit", "initials": "R", "orcid": "0000-0001-7531-8038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6264cc40882f4edfb084e2055945df26.json"}}, {"family": "COVAD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-15", "journal": {"title": "Rheumatol Int", "issn": "1437-160X", "issn-l": null}, "abstract": "The coronavirus disease-2019 (COVID-19) pandemic continues to be a cause of unprecedented global morbidity and mortality. Whilst COVID-19 vaccination has emerged as the only tangible solution to reducing poor clinical outcomes, vaccine hesitancy continues to be an obstacle to achieving high levels of vaccine uptake. This represents particular risk to patients with autoimmune diseases, a group already at increased risk of hospitalization and poor clinical outcomes related to COVID-19 infection. Whilst there is a paucity of long-term safety and efficacy data of COVID-19 vaccination in patients with autoimmune diseases, the current evidence strongly suggests that the benefits of vaccination outweigh the risks of adverse effects and disease flares. Herein, we report the protocol of the COVID-19 Vaccination in Autoimmune Diseases (COVAD) study, an ongoing international collaborative study involving 29 countries and over 110 investigators.", "doi": "10.1007/s00296-021-05046-4", "pmid": "34779868", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00296-021-05046-4"}, {"db": "pmc", "key": "PMC8591970"}], "notes": [], "created": "2021-11-26T14:12:43.355Z", "modified": "2021-11-26T14:12:44.102Z"}, {"entity": "publication", "iuid": "58c44fae885640b0a222a91d48740176", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/58c44fae885640b0a222a91d48740176.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/58c44fae885640b0a222a91d48740176"}}, "title": "Utilization of health care services before and after media attention about fatal side effects of the AstraZeneca vaccine: a nation-wide register-based event study.", "authors": [{"family": "Larsen", "given": "Vilde Bergstad", "initials": "VB"}, {"family": "Gr\u00f8sland", "given": "Mari", "initials": "M"}, {"family": "Telle", "given": "Kjetil", "initials": "K"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2021-11-13", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "issn-l": null, "volume": "21", "issue": "1", "pages": "1229"}, "abstract": "Survey studies have found that vaccinated persons tend to report more side effects after being given information about side effects rather than benefits. However, the impact of high media attention about vaccine-related side effects on the utilization of health care is unknown. We aimed to assess whether utilization of health care services for newly vaccinated health care workers changed after media attention about fatal side effects of the AstraZeneca vaccine on March 11th, 2021, and whether changes differed by age, sex, or occupation.\r\n\r\nWe utilized individual-level data on health care use, vaccination, employment, and demographics available in the Norwegian emergency preparedness register Beredt C19. In all 99,899 health care workers in Norway who were vaccinated with AstraZeneca between February 11th and March 11th, we used an event-study design with a matched comparison group to compare the change in primary and inpatient specialist care use from 14 days before to 14 days after the information shock on March 11th, 2021.\r\n\r\nPrimary health care use increased with 8.2 daily consultations per 1000 health care workers (95% CI 7.51 to 8.89) the week following March 11th for those vaccinated with AstraZeneca (n = 99,899), compared with no increase for the unvaccinated comparison group (n = 186,885). Utilization of inpatient care also increased with 0.8 daily hospitalizations per 1000 health care workers (95% CI 0.37 to 1.23) in week two after March 11th. The sharpest increase in daily primary health care use in the first week after March 11th was found for women aged 18-44 (10.6 consultations per 1000, 95% CI 9.52 to 11.68) and for cleaners working in the health care sector (9.8 consultations per 1000, 95% CI 3.41 to 16.19).\r\n\r\nHealth care use was higher after the media reports of a few cases of fatal or severe side effects of the AstraZeneca vaccine. Our results suggest that the reports did not only lead vaccinated individuals to contact primary health care more, but also that physicians referred and treated more cases to specialist care after the new information.", "doi": "10.1186/s12913-021-07233-2", "pmid": "34774045", "labels": {"Type: Journal article": null, "Topics: Register-based research": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-021-07233-2"}, {"db": "pmc", "key": "PMC8590367"}], "notes": [], "created": "2021-11-26T15:07:46.550Z", "modified": "2021-11-29T06:06:38.104Z"}, {"entity": "publication", "iuid": "550af56a537a48ef9b110f14802614cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/550af56a537a48ef9b110f14802614cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/550af56a537a48ef9b110f14802614cb"}}, "title": "Just how common is TTS after a second dose of the ChAdOx1 nCov-19 vaccine? - Authors' reply.", "authors": [{"family": "Bhuyan", "given": "Prakash", "initials": "P"}, {"family": "Medin", "given": "Jennie", "initials": "J"}, {"family": "da Silva", "given": "Hugo Gomes", "initials": "HG"}, {"family": "Yadavalli", "given": "Madhavi", "initials": "M"}, {"family": "Nord", "given": "Magnus", "initials": "M"}], "type": "letter", "published": "2021-11-13", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "398", "issue": "10313", "pages": "1801-1802", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(21)02317-5", "pmid": "34774142", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)02317-5"}], "notes": [], "created": "2021-11-26T14:29:42.406Z", "modified": "2021-11-26T14:29:42.420Z"}, {"entity": "publication", "iuid": "194df91105ef49e1ad019cfe7228e489", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/194df91105ef49e1ad019cfe7228e489.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/194df91105ef49e1ad019cfe7228e489"}}, "title": "General stress among young adults with asthma during the COVID-19 pandemic.", "authors": [{"family": "Ekstr\u00f6m", "given": "Sandra", "initials": "S"}, {"family": "Mogensen", "given": "Ida", "initials": "I"}, {"family": "Georgelis", "given": "Antonios", "initials": "A"}, {"family": "Westman", "given": "Marit", "initials": "M"}, {"family": "Almqvist", "given": "Catarina", "initials": "C"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Bergstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "BAMSE COVID-19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-13", "journal": {"title": "J Allergy Clin Immunol Pract", "issn": "2213-2201", "issn-l": null}, "abstract": "The COVID-19 pandemic has profoundly affected the lives of the global population.\n\nTo explore anxiety and stress in relation to COVID-19 among young adults, and the potential influence of asthma and allergic rhinitis.\n\nThis cross-sectional study included 1,644 participants from the population-based birth cohort BAMSE, participating in a follow-up at 24 years of age and a COVID-19 follow-up conducted in August-November 2020 (mean age 25.3 years). Anxiety and concern related to COVID-19 were analyzed as general anxiety, concern of own health and health of family members, and contact with online healthcare providers due to concern about COVID-19. Stress was measured with the perceived stress scale (PSS-10).\n\nAround half of the participants reported increased anxiety due to COVID-19 and this was more common among females (57.0%, compared to 42.6% in males, p<0.001). Young adults with asthma reported more concern about their own health (adjusted odds ratio (adj OR): 1.50, 95% confidence interval (CI): 1.12-2.02) and perceived stress (adjusted regression coefficient (adj \u03b2): 1.49 CI: 0.52-2.45) compared to peers without asthma, and this was more pronounced among females and those with uncontrolled asthma. Symptoms of allergic rhinitis were not associated with increased concern or anxiety in relation to COVID-19.\n\nYoung adults with asthma experience more COVID-19 related health concerns, compared to those without asthma; especially females and participants with uncontrolled asthma This needs to be considered in the care of young people with asthma.", "doi": "10.1016/j.jaip.2021.10.069", "pmid": "34785389", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2213-2198(21)01260-5"}, {"db": "pmc", "key": "PMC8590620"}], "notes": [], "created": "2021-11-26T14:11:36.607Z", "modified": "2021-11-26T14:11:36.621Z"}, {"entity": "publication", "iuid": "0dcc8509723f41338670ce7ef4e5bb71", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0dcc8509723f41338670ce7ef4e5bb71.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0dcc8509723f41338670ce7ef4e5bb71"}}, "title": "Gaming Activity and Possible Changes in Gaming Behavior Among Young People During the COVID-19 Pandemic: Cross-sectional Online Survey Study.", "authors": [{"family": "Claesdotter-Knutsson", "given": "Emma", "initials": "E"}, {"family": "Andr\u00e9", "given": "Frida", "initials": "F"}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-11-13", "journal": {"title": "JMIR Serious Games", "issn": "2291-9279", "issn-l": null}, "abstract": "Young people's daily lives and social interactions changed remarkably during the COVID-19 pandemic as schools and cinemas closed, leisure activities were cancelled, and gatherings were regulated. Questions have been raised by the media, schools, policymakers and research communities about the effect on young people's online behaviors.\n\nThe aim of this cross-sectional study was to study self-reported changes in gaming, focusing on a younger section of the population during the COVID-19 pandemic in Sweden. We also wanted to look at potential risk factors behind problematic gaming during the pandemic, including gaming patterns, gambling behavior, psychological distress, certain sociodemographic characteristics, health factors, and school situation.\n\nThis was an anonymous online survey study of web panel participants in Sweden (N=1,501) to study changes in gaming behaviors during the COVID-19 pandemic. Self-reported increases in gaming were analyzed in logistic regressions against sociodemographic and health factors.\n\nWithin the whole study population that reported changes in gaming activity we found significant differences in age, employment status, disposable income, whether they ever played on loot boxes, time spent at home, school attendance, psychological distress, gambling and gaming problems, and significant differences in changes in alcohol consumption and changes in exercise habits. When examining the age group 16-24 years old that reported changes in gaming activity, we found significant differences within the group in disposable income, time at home and school attendance. When examining the age group 25-39 years old that reported changes in gaming activity, we found significant differences within the group in employment status, disposable income, time spent at home, whether the respondents are studying, school attendance level, psychological distress, gaming problems, as well as significant differences in changes in alcohol consumption and changes in exercise habits. Psychological distress (all age groups analyzed together; age group 25-39 years old), drinking less alcohol (all age groups analyzed together), spending more time at home (all age groups analyzed together), gaming problems and exercising less (age group 25-39 years old) were positively correlated to a self-reported increase in gaming activity. Being employed (age group 25-39 years old) and being over 40 years of age (all age groups analyzed together) were negatively correlated to increased gaming. We found no significant correlations in the age group 16-24 years old.\n\nThose who reported increased gaming during the COVID-19 pandemic were more likely to be 16-39 years old. In the age group 25-39 years old the increase was associated with psychological distress, reporting less exercise and being unemployed. COVID-19 may present a risk factor of increased online gaming in a small but vulnerable group. More research and preferably longitudinal studies are needed in the field of gaming and effects of the COVID-19 pandemic.", "doi": "10.2196/33059", "pmid": "34817386", "labels": {"Type: Journal article": null, "Category: Other": null, "Topics: Register-based research": null}, "xrefs": [], "notes": [], "created": "2021-11-26T13:06:15.801Z", "modified": "2021-12-18T18:22:51.084Z"}, {"entity": "publication", "iuid": "be53c97c1d794cc586bdddce6d92d246", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be53c97c1d794cc586bdddce6d92d246.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be53c97c1d794cc586bdddce6d92d246"}}, "title": "Beneficial Effects of Anticoagulants on the Clinical Outcomes of COVID-19 Patients.", "authors": [{"family": "Jamil", "given": "Zubia", "initials": "Z"}, {"family": "Khan", "given": "Azmat Ali", "initials": "AA", "orcid": "0000-0001-5955-3783", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fbf30007a9a4702b4fb2171acf8b7a4.json"}}, {"family": "Khalid", "given": "Samreen", "initials": "S"}, {"family": "Asghar", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-9017-2206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0e95806bb4a4dca8363a6d9618c678d.json"}}, {"family": "Muhammad", "given": "Khalid", "initials": "K", "orcid": "0000-0001-6488-1722", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a33153a6137841cbaec30e195174ddff.json"}}, {"family": "Waheed", "given": "Yasir", "initials": "Y", "orcid": "0000-0002-5789-4215", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9dc6b28db595446b8d4fd02142a077e0.json"}}], "type": "journal article", "published": "2021-11-13", "journal": {"title": "Antibiotics (Basel)", "issn": "2079-6382", "volume": "10", "issue": "11", "issn-l": null}, "abstract": "(1) Background: Severe coronavirus disease can be complicated by a hypercoagulable state in conjunction with sepsis, increasing the risk of venous thromboembolism. This study aimed to observe the effect of anticoagulants on 30-day high-dependency unit (HDU) outcomes of moderate to severe coronavirus disease 2019 (COVID-19) patients of a tertiary care hospital at Rawalpindi, Pakistan. (2) Methods: A retrospective propensity-based case-control study was carried out to examine COVID-19 patients admitted to the HDU. Patient groups who did and did not receive anticoagulants were labeled as \"anticoagulant\" and \"non-anticoagulant\", respectively. Case-control matching (1:1) was performed via propensity scores (calculated by a regression model). Kaplan-Meier and logrank analyses were used to study survival probability. Single predictors of outcomes were determined by Cox regression analysis. (3) Results: The anticoagulant group had elevated D-dimers, advanced age, more comorbidities and a higher frequency of severe disease compared to the non-anticoagulant group (p < 0.05). Therefore, 47 cases and 47 matched controls were selected based on their propensity scores. The primary endpoint was outcome (survived vs. died). The 30-day in-HDU mortality was 25.5% for cases and 61.7% for controls (p = 0.0004). The median time from admission to death was 16 days for the case group and 7 days for the control group (p < 0.0001). The 30-day mortality was 19.1% for the enoxaparin group and 16.4% for the heparin group (p > 0.05). Enoxaparin (therapeutic and prophylactic doses) and heparin (prophylactic dose) were found to be independent factors affecting the outcomes of these patients (p < 0.001). (4) Conclusions: Anticoagulants play a beneficial role in reducing mortality among COVID-19 patients. Both anticoagulant formulations, enoxaparin (therapeutic and prophylactic doses) and heparin (prophylactic dose), were associated with improving survival among these patients.", "doi": "10.3390/antibiotics10111394", "pmid": "34827332", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "antibiotics10111394"}, {"db": "pmc", "key": "PMC8615249"}], "notes": [], "created": "2021-12-18T18:17:40.214Z", "modified": "2021-12-18T18:17:40.354Z"}, {"entity": "publication", "iuid": "aa0ac8acb86d4d32907c7a91390df8c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aa0ac8acb86d4d32907c7a91390df8c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aa0ac8acb86d4d32907c7a91390df8c0"}}, "title": "Partial oral antibiotic treatment for bacterial brain abscess: an open-label randomized non-inferiority trial (ORAL).", "authors": [{"family": "Bodilsen", "given": "Jacob", "initials": "J", "orcid": "0000-0002-7398-814X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d14a292f44b4962bb6d543d059debc8.json"}}, {"family": "Brouwer", "given": "Matthijs C", "initials": "MC"}, {"family": "van de Beek", "given": "Diederik", "initials": "D"}, {"family": "Tattevin", "given": "Pierre", "initials": "P"}, {"family": "Tong", "given": "Steven", "initials": "S"}, {"family": "Naucler", "given": "Pontus", "initials": "P"}, {"family": "Nielsen", "given": "Henrik", "initials": "H"}], "type": "equivalence trial", "published": "2021-11-12", "journal": {"title": "Trials", "issn": "1745-6215", "volume": "22", "issue": "1", "pages": "796", "issn-l": null}, "abstract": "The advised standard treatment for bacterial brain abscess following surgery is 6 to 8 weeks of intravenous (IV) antibiotic treatment, but an early switch to oral antibiotic treatment has been suggested to be equally effective.\n\nThis investigator-initiated, international, multi-center, parallel group, open-label, randomized (1:1 allocation) controlled trial will examine if oral treatment after 2 weeks of IV antibiotic therapy is non-inferior to standard 6-8 weeks of IV antibiotics for bacterial brain abscess in adults (\u2265 18 years of age). The study will be conducted at hospitals across Denmark, the Netherlands, France, Australia, and Sweden. Exclusion criteria are severe immunocompromise or impaired gastro-intestinal absorption, pregnancy, device-related brain abscesses, and brain abscess caused by nocardia, tuberculosis, or Pseudomonas spp. The primary objective is a composite endpoint at 6 months after randomization consisting of all-cause mortality, intraventricular rupture of brain abscess, unplanned re-aspiration or excision of brain abscess, relapse, or recurrence. The primary endpoint will be adjudicated by an independent blinded endpoint committee. Secondary outcomes include extended Glasgow Outcome Scale scores and all-cause mortality at end of treatment as well as 3, 6, and 12 months since randomization, completion of assigned treatment, IV catheter associated complications, durations of admission and antibiotic treatment, severe adverse events, quality of life scores, and cognitive evaluations. The planned sample size is 450 patients for a one-sided alpha of 0.025 and a power of 90% to exclude a difference in favor of standard treatment of more than 10%. Date of initiation of first study center was November 3, 2020, with active recruitment for 3 years and follow-up for 1 year of all patients.\n\nThe results of this study may guide future recommendations for treatment of bacterial brain abscess. If early transition to oral antibiotics proves non-inferior to standard IV treatment, this will provide considerable health and costs benefits.\n\nClinicalTrials.gov NCT04140903, first registered 28.10.2019. EudraCT number: 2019-002845-39, first registered 03.07.2019.", "doi": "10.1186/s13063-021-05783-8", "pmid": "34772441", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13063-021-05783-8"}, {"db": "pmc", "key": "PMC8588941"}, {"db": "ClinicalTrials.gov", "key": "NCT04140903"}], "notes": [], "created": "2021-11-26T15:08:14.926Z", "modified": "2021-11-26T15:08:14.985Z"}, {"entity": "publication", "iuid": "00e2bf08d8c844b4a437f7a44ec4e7d2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/00e2bf08d8c844b4a437f7a44ec4e7d2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/00e2bf08d8c844b4a437f7a44ec4e7d2"}}, "title": "The association between first and second wave COVID-19 mortality in Italy.", "authors": [{"family": "Vinceti", "given": "Marco", "initials": "M", "orcid": "0000-0002-0551-2473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a25953d69dcd4b9bb597385be88340bc.json"}}, {"family": "Filippini", "given": "Tommaso", "initials": "T", "orcid": "0000-0003-2100-0344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/caaa012b164e4fe3962d2cce410cd008.json"}}, {"family": "Rothman", "given": "Kenneth J", "initials": "KJ", "orcid": "0000-0003-2398-1705", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60d1be3be5cd4d40a4bd796f7b5faed1.json"}}, {"family": "Di Federico", "given": "Silvia", "initials": "S"}, {"family": "Orsini", "given": "Nicola", "initials": "N", "orcid": "0000-0002-2210-5634", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6161818f1f74a26883d3b1e37e72f2e.json"}}], "type": "journal article", "published": "2021-11-11", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "21", "issue": "1", "pages": "2069", "issn-l": null}, "abstract": "The relation between the magnitude of successive waves of the COVID-19 outbreak within the same communities could be useful in predicting the scope of new outbreaks.\n\nWe investigated the extent to which COVID-19 mortality in Italy during the second wave was related to first wave mortality within the same provinces. We compared data on province-specific COVID-19 2020 mortality in two time periods, corresponding to the first wave (February 24-June 30, 2020) and to the second wave (September 1-December 31, 2020), using cubic spline regression.\n\nFor provinces with the lowest crude mortality rate in the first wave (February-June), i.e. < 22 cases/100,000/month, mortality in the second wave (September-December) was positively associated with mortality during the first wave. In provinces with mortality greater than 22/100,000/month during the first wave, higher mortality in the first wave was associated with a lower second wave mortality. Results were similar when the analysis was censored at October 2020, before the implementation of region-specific measures against the outbreak. Neither vaccination nor variant spread had any role during the study period.\n\nThese findings indicate that provinces with the most severe initial COVID-19 outbreaks, as assessed through mortality data, faced milder second waves.", "doi": "10.1186/s12889-021-12126-4", "pmid": "34763690", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-12126-4"}, {"db": "pmc", "key": "PMC8582237"}], "notes": [], "created": "2021-11-26T15:15:22.465Z", "modified": "2021-11-26T15:15:22.635Z"}, {"entity": "publication", "iuid": "30a7a3647f8048f39edc4c8f51995693", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/30a7a3647f8048f39edc4c8f51995693.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/30a7a3647f8048f39edc4c8f51995693"}}, "title": "Does COVID-19 cause pre-eclampsia?", "authors": [{"family": "Khalil", "given": "A", "initials": "A", "orcid": "0000-0003-2802-7670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e4558e368114cfb83c4594f523b38c0.json"}}, {"family": "Samara", "given": "A", "initials": "A"}, {"family": "Chowdhury", "given": "T", "initials": "T"}, {"family": "O'Brien", "given": "P", "initials": "P"}], "type": "journal article", "published": "2021-11-11", "journal": {"title": "Ultrasound Obstet Gynecol", "issn": "1469-0705", "issn-l": null}, "abstract": null, "doi": "10.1002/uog.24809", "pmid": "34766403", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-11-26T15:14:32.705Z", "modified": "2021-11-26T15:14:32.763Z"}, {"entity": "publication", "iuid": "cf772b0823c44d21af699e5a1a2d38f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cf772b0823c44d21af699e5a1a2d38f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cf772b0823c44d21af699e5a1a2d38f2"}}, "title": "Conducting In-Depth Interviews via Mobile Phone with Persons with Common Mental Disorders and Multimorbidity: The Challenges and Advantages as Experienced by Participants and Researchers.", "authors": [{"family": "Azad", "given": "Azad\u00e9", "initials": "A"}, {"family": "Sernbo", "given": "Elisabet", "initials": "E"}, {"family": "Sv\u00e4rd", "given": "Veronica", "initials": "V", "orcid": "0000-0002-3868-0254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7ca2d10512349b99cee9e0f1c5dc274.json"}}, {"family": "Holmlund", "given": "Lisa", "initials": "L", "orcid": "0000-0001-8321-0174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53f74a6dae5e489782ca1566f3edea16.json"}}, {"family": "Bj\u00f6rk Br\u00e4mberg", "given": "Elisabeth", "initials": "E", "orcid": "0000-0002-0204-5144", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ecc3851dd7b44208efeea67732361a3.json"}}], "type": "journal article", "published": "2021-11-11", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "22", "issn-l": null}, "abstract": "Qualitative interviews are generally conducted in person. As the coronavirus pandemic (COVID-19) prevents in-person interviews, methodological studies which investigate the use of the telephone for persons with different illness experiences are needed. The aim was to explore experiences of the use of telephone during semi-structured research interviews, from the perspective of participants and researchers. Data were collected from mobile phone interviews with 32 individuals who had common mental disorders or multimorbidity which were analyzed thematically, as well as field notes reflecting researchers' experiences. The findings reveal several advantages of conducting interviews using mobile phones: flexibility, balanced anonymity and power relations, as well as a positive effect on self-disclosure and emotional display (leading to less emotional work and social responsibility). Challenges included the loss of human encounter, intense listening, and worries about technology, as well as sounds or disturbances in the environment. However, the positive aspects of not seeing each other were regarded as more important. In addition, we present some strategies before, during, and after conducting telephone interviews. Telephone interviews can be a valuable first option for data collection, allowing more individuals to be given a fair opportunity to share their experiences.", "doi": "10.3390/ijerph182211828", "pmid": "34831582", "labels": {"Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182211828"}, {"db": "pmc", "key": "PMC8619936"}], "notes": [], "created": "2021-12-18T18:16:12.225Z", "modified": "2021-12-18T18:16:12.357Z"}, {"entity": "publication", "iuid": "f49303d656f140cfa8c868576cd1316b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f49303d656f140cfa8c868576cd1316b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f49303d656f140cfa8c868576cd1316b"}}, "title": "Potential impact of the COVID-19 pandemic on the national and regional incidence, epidemiology and diagnostic testing of chlamydia and gonorrhoea in Sweden, 2020.", "authors": [{"family": "Saarentausta", "given": "Katariina", "initials": "K"}, {"family": "Ivarsson", "given": "Lovisa", "initials": "L"}, {"family": "Jacobsson", "given": "Susanne", "initials": "S"}, {"family": "Herrmann", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Sundqvist", "given": "Martin", "initials": "M"}, {"family": "Unemo", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-11-10", "journal": {"title": "APMIS", "issn": "1600-0463", "issn-l": null}, "abstract": "The COVID-19 pandemic has challenged the societies and health care systems globally, and resulted in many social and physical distancing restrictions to limit the spread of SARS-CoV-2. These restrictions have also likely affected the frequency of intimate contacts and the spread of sexually transmitted infections (STIs). Compared to most other countries, Sweden especially in Spring-Autumn 2020 pursued mainly milder voluntary, that is, not mandatory enforced by laws, recommended restrictions and the impacts of these on society and spread of STIs remain largely unknown. We describe the potential impact of the COVID-19 pandemic on the national and regional incidence, epidemiology and diagnostic testing of chlamydia and gonorrhoea in Sweden in 2020. Compared to 2019, we found a significant decrease in incidence of chlamydia (-4.5%) and gonorrhoea (-17.5%), and in diagnostic testing (-10.5% for chlamydia, -9.4% for gonorrhoea) in 2020. However, the decrease in chlamydia incidence, which has mainly been decreasing in the last 10 years, was not significant when compared with the average incidence in 2017-2019. The largest decrease in national incidence of both infections was observed among young and heterosexual patients, however, some Swedish regions showed an increased incidence, particularly of chlamydia. Increased \"internet-based self-sampling\" testing approach partly compensated for a decreased attendance at STI clinics. Studies, including sexual behaviour, prevention, reasons for attending STI health care, STIs in different anatomical sites and management of STIs, are required to elucidate the impact of COVID-19-associated social and physical distancing restrictions on sexual activity and the incidence and epidemiology of chlamydia and gonorrhoea in Sweden.", "doi": "10.1111/apm.13191", "pmid": "34758169", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T15:22:34.410Z", "modified": "2021-11-26T15:22:34.431Z"}, {"entity": "publication", "iuid": "53dd7dfa906448b1aea795e4962f0f89", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53dd7dfa906448b1aea795e4962f0f89.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53dd7dfa906448b1aea795e4962f0f89"}}, "title": "Impacts of mild and severe COVID-19 on sick leave.", "authors": [{"family": "Skyrud", "given": "Katrine", "initials": "K", "orcid": "0000-0001-7504-9253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa7b45c41c544ba098093febd55117c8.json"}}, {"family": "Telle", "given": "Kjetil", "initials": "K"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2021-11-10", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "issn-l": "0300-5771", "volume": "50", "issue": "5", "pages": "1745-1747"}, "abstract": null, "doi": "10.1093/ije/dyab182", "pmid": "34458903", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6359516"}, {"db": "pmc", "key": "PMC8499817"}], "notes": [], "created": "2021-09-01T07:47:46.351Z", "modified": "2021-11-18T13:50:25.240Z"}, {"entity": "publication", "iuid": "b272ffc2e1ba4ad9b0ea7696c08ed7bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b272ffc2e1ba4ad9b0ea7696c08ed7bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b272ffc2e1ba4ad9b0ea7696c08ed7bf"}}, "title": "From chaos to control - experiences of healthcare workers during the early phase of the COVID-19 pandemic: a focus group study.", "authors": [{"family": "R\u00fccker", "given": "Fredrik", "initials": "F"}, {"family": "H\u00e5rdstedt", "given": "Maria", "initials": "M"}, {"family": "R\u00fccker", "given": "Sekai Chenai Mathabire", "initials": "SCM"}, {"family": "Aspelin", "given": "Emma", "initials": "E"}, {"family": "Smirnoff", "given": "Alexander", "initials": "A"}, {"family": "Lindblom", "given": "Anders", "initials": "A"}, {"family": "Gustavsson", "given": "Catharina", "initials": "C", "orcid": "0000-0002-8709-4446", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ccad80107b2d47289e4a795a8dfb4a26.json"}}], "type": "journal article", "published": "2021-11-10", "journal": {"title": "BMC Health Serv Res", "issn": "1472-6963", "volume": "21", "issue": "1", "pages": "1219", "issn-l": null}, "abstract": "The Coronavirus disease 2019 (COVID-19) pandemic has caused overwhelming challenges to healthcare systems worldwide. Healthcare workers (HCWs) have faced particular challenges: being exposed to the coronavirus SARS-CoV-2 and caring for patients having a new and potentially life-threatening disease. The aim of this study was to explore how HCWs in the Swedish healthcare system perceived their work situation during the first phase of the COVID-19 pandemic in 2020.\n\nFocus group discussions and interviews with HCWs were performed from June to October 2020 in one Swedish healthcare region. A purposeful sampling approach was used to select a variety of professions (physicians, nurses, nurse aides and cleaners) and workplaces (hospital inpatient wards, emergency department, nursing home and home care service). Qualitative content analysis was used for data analysis.\n\nIn total, 51 HCWs participated in eight focus group discussions and one HCW participated in an individual interview. The content analysis identified two main categories: 'Concerns about the risk of infection and transmission of infection to others', and 'Transition from chaos to managing in a new and challenging work situation'. The findings revealed how HCWs perceived working conditions, including experiences of fear for personal health, confusion and uncertainty regarding personal protective equipment and infection prevention and control (PPE/IPC), and fear of infecting others. Both fearful and appreciating attitudes were achieved from the surrounding community. Helpful strategies for transition from chaos to control were lifted i.e. present and supportive leadership, and finding comfort and strength in the working team. Both helplessness and meaningfulness were described when caring for COVID-19 patients.\n\nThis study provides unique insights into HCWs experiences of an extremely challenging work situation during the first phase of the COVID-19 pandemic, including feelings of stress and insecurity in a chaotic and hazardous working environment. But there is also mitigation of these challenges and even positive experiences including feelings of safety and meaningfulness. To enhance safety among HCWs in healthcare crises such as the COVID-19 pandemic, the findings highlight the importance of avoiding confusion about PPE/IPC, having a supportive healthcare leadership and ensuring accurate information provision about virus transmission to the public.", "doi": "10.1186/s12913-021-07248-9", "pmid": "34758837", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12913-021-07248-9"}, {"db": "pmc", "key": "PMC8579171"}], "notes": [], "created": "2021-11-26T15:22:04.914Z", "modified": "2021-11-26T15:22:04.968Z"}, {"entity": "publication", "iuid": "c1a3fc23659846ab983c7656417045fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1a3fc23659846ab983c7656417045fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1a3fc23659846ab983c7656417045fc"}}, "title": "Fear of COVID-19 lead to procrastination among Turkish university students: The mediating role of intolerance of uncertainty.", "authors": [{"family": "Do\u011fan\u00fclk\u00fc", "given": "Hac\u0131 Arif", "initials": "HA"}, {"family": "Korkmaz", "given": "Ozan", "initials": "O"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-11-10", "journal": {"title": "BMC Psychol", "issn": "2050-7283", "volume": "9", "issue": "1", "pages": "178", "issn-l": null}, "abstract": "The COVID-19 outbreak has not only increased mortality but has also negatively affected mental health among populations across the world. Furthermore, individuals are experiencing uncertainty about their current and future situation because of the pandemic. Therefore, the present study investigated the mediating role of intolerance of uncertainty in the relationship between fear of COVID-19 and procrastination among a sample of Turkish university students.\n\nBetween October and November 2020, 450 university students (291 females and 159 males aged 17 to 24 years) from three state universities in Turkey completed an online survey. Correlation analysis and structural equation modeling methods were employed to examine a model for understanding the general procrastination during COVID-19 pandemic.\n\nThe results of the correlation analysis indicated that the fear of COVID-19 was positively correlated with both intolerance of uncertainty (r = .26, p < .001) and procrastination (r = .23, p < .001). The mediation analysis also showed that intolerance of uncertainty had a significant mediating role in the relationship between fear of COVID-19 and procrastination (\u03b2 = .11, p < .001).\n\nReducing the fear of COVID-19 and intolerance of uncertainty is likely to contribute to reducing individuals' procrastination behaviors during the pandemic.", "doi": "10.1186/s40359-021-00681-9", "pmid": "34758865", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s40359-021-00681-9"}, {"db": "pmc", "key": "PMC8579725"}], "notes": [], "created": "2021-11-26T15:21:49.770Z", "modified": "2021-11-26T15:21:49.804Z"}, {"entity": "publication", "iuid": "82f55ec89a3747aaa9cc0ee95306a936", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82f55ec89a3747aaa9cc0ee95306a936.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82f55ec89a3747aaa9cc0ee95306a936"}}, "title": "Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trial.", "authors": [{"family": "Granholm", "given": "Anders", "initials": "A", "orcid": "0000-0001-5799-7655", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d058ecb91d4c482abbee511b044ddf75.json"}}, {"family": "Munch", "given": "Marie Warrer", "initials": "MW"}, {"family": "Myatra", "given": "Sheila Nainan", "initials": "SN"}, {"family": "Vijayaraghavan", "given": "Bharath Kumar Tirupakuzhi", "initials": "BKT"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Wahlin", "given": "Rebecka Rubenson", "initials": "RR"}, {"family": "Jakob", "given": "Stephan M", "initials": "SM"}, {"family": "Cioccari", "given": "Luca", "initials": "L"}, {"family": "Kj\u00e6r", "given": "Maj-Brit N\u00f8rregaard", "initials": "MN"}, {"family": "Vesterlund", "given": "Gitte Kingo", "initials": "GK"}, {"family": "Meyhoff", "given": "Tine Sylvest", "initials": "TS"}, {"family": "Helleberg", "given": "Marie", "initials": "M"}, {"family": "M\u00f8ller", "given": "Morten Hylander", "initials": "MH"}, {"family": "Benfield", "given": "Thomas", "initials": "T"}, {"family": "Venkatesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Hammond", "given": "Naomi E", "initials": "NE"}, {"family": "Micallef", "given": "Sharon", "initials": "S"}, {"family": "Bassi", "given": "Abhinav", "initials": "A"}, {"family": "John", "given": "Oommen", "initials": "O"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Kristiansen", "given": "Klaus Tjelle", "initials": "KT"}, {"family": "Ulrik", "given": "Charlotte Suppli", "initials": "CS"}, {"family": "J\u00f8rgensen", "given": "Vibeke Lind", "initials": "VL"}, {"family": "Smitt", "given": "Margit", "initials": "M"}, {"family": "Bestle", "given": "Morten H", "initials": "MH"}, {"family": "Andreasen", "given": "Anne Sofie", "initials": "AS"}, {"family": "Poulsen", "given": "Lone Musaeus", "initials": "LM"}, {"family": "Rasmussen", "given": "Bodil Steen", "initials": "BS"}, {"family": "Br\u00f8chner", "given": "Anne Craveiro", "initials": "AC"}, {"family": "Str\u00f8m", "given": "Thomas", "initials": "T"}, {"family": "M\u00f8ller", "given": "Anders", "initials": "A"}, {"family": "Khan", "given": "Mohd Saif", "initials": "MS"}, {"family": "Padmanaban", "given": "Ajay", "initials": "A"}, {"family": "Divatia", "given": "Jigeeshu Vasishtha", "initials": "JV"}, {"family": "Saseedharan", "given": "Sanjith", "initials": "S"}, {"family": "Borawake", "given": "Kapil", "initials": "K"}, {"family": "Kapadia", "given": "Farhad", "initials": "F"}, {"family": "Dixit", "given": "Subhal", "initials": "S"}, {"family": "Chawla", "given": "Rajesh", "initials": "R"}, {"family": "Shukla", "given": "Urvi", "initials": "U"}, {"family": "Amin", "given": "Pravin", "initials": "P"}, {"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Wamberg", "given": "Christian Aage", "initials": "CA"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Lange", "given": "Theis", "initials": "T"}, {"family": "Perner", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-11-10", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "issn-l": "0342-4642"}, "abstract": "We compared dexamethasone 12 versus 6 mg daily for up to 10 days in patients with coronavirus disease 2019 (COVID-19) and severe hypoxaemia in the international, randomised, blinded COVID STEROID 2 trial. In the primary, conventional analyses, the predefined statistical significance thresholds were not reached. We conducted a pre-planned Bayesian analysis to facilitate probabilistic interpretation.\n\nWe analysed outcome data within 90 days in the intention-to-treat population (data available in 967 to 982 patients) using Bayesian models with various sensitivity analyses. Results are presented as median posterior probabilities with 95% credible intervals (CrIs) and probabilities of different effect sizes with 12 mg dexamethasone.\n\nThe adjusted mean difference on days alive without life support at day 28 (primary outcome) was 1.3 days (95% CrI -0.3 to 2.9; 94.2% probability of benefit). Adjusted relative risks and probabilities of benefit on serious adverse reactions was 0.85 (0.63 to 1.16; 84.1%) and on mortality 0.87 (0.73 to 1.03; 94.8%) at day 28 and 0.88 (0.75 to 1.02; 95.1%) at day 90. Probabilities of benefit on days alive without life support and days alive out of hospital at day 90 were 85 and 95.7%, respectively. Results were largely consistent across sensitivity analyses, with relatively low probabilities of clinically important harm with 12 mg on all outcomes in all analyses.\n\nWe found high probabilities of benefit and low probabilities of clinically important harm with dexamethasone 12 mg versus 6 mg daily in patients with COVID-19 and severe hypoxaemia on all outcomes up to 90 days.", "doi": "10.1007/s00134-021-06573-1", "pmid": "34757439", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-021-06573-1"}, {"db": "pmc", "key": "PMC8579417"}, {"db": "ClinicalTrials.gov", "key": "NCT04509973"}, {"db": "CTRI", "key": "CTRI/2020/10/028731"}], "notes": [], "created": "2021-11-26T15:22:50.796Z", "modified": "2021-11-26T15:22:50.839Z"}, {"entity": "publication", "iuid": "44db6ce5a85b416fb6d9dbeff3b0ba79", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44db6ce5a85b416fb6d9dbeff3b0ba79.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44db6ce5a85b416fb6d9dbeff3b0ba79"}}, "title": "Crosstalk between the renin-angiotensin, complement and kallikrein-kinin systems in inflammation.", "authors": [{"family": "Bekassy", "given": "Zivile", "initials": "Z", "orcid": "0000-0002-5942-281X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/66f1635f53944e9b9bea08d62caa4f17.json"}}, {"family": "Lopatko Fagerstr\u00f6m", "given": "Ingrid", "initials": "I"}, {"family": "Bader", "given": "Michael", "initials": "M"}, {"family": "Karpman", "given": "Diana", "initials": "D", "orcid": "0000-0001-7220-7658", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a7a12da87fb48359206955185eb7b4e.json"}}], "type": "journal article", "published": "2021-11-10", "journal": {"title": "Nat Rev Immunol", "issn": "1474-1741", "issn-l": "1474-1733"}, "abstract": "During severe inflammatory and infectious diseases, various mediators modulate the equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review describes the interactive roles of the renin-angiotensin system, the complement system, and the closely linked kallikrein-kinin and contact systems in cell biological functions such as vascular tone and leakage, inflammation, chemotaxis, thrombosis and cell proliferation. Specific attention is given to the role of these systems in systemic inflammation in the vasculature and tissues during hereditary angioedema, cardiovascular and renal glomerular disease, vasculitides and COVID-19. Moreover, we discuss the therapeutic implications of these complex interactions, given that modulation of one system may affect the other systems, with beneficial or deleterious consequences.", "doi": "10.1038/s41577-021-00634-8", "pmid": "34759348", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41577-021-00634-8"}, {"db": "pmc", "key": "PMC8579187"}], "notes": [], "created": "2021-11-26T15:21:35.598Z", "modified": "2021-11-26T15:21:35.698Z"}, {"entity": "publication", "iuid": "64996e79702540a8a8c5a5ec12612391", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/64996e79702540a8a8c5a5ec12612391.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/64996e79702540a8a8c5a5ec12612391"}}, "title": "Prevalence of Gastrointestinal Symptoms in Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Results of the Prospective Controlled Multinational GI-COVID-19 Study.", "authors": [{"family": "Marasco", "given": "Giovanni", "initials": "G"}, {"family": "Cremon", "given": "Cesare", "initials": "C"}, {"family": "Barbaro", "given": "Maria Raffaella", "initials": "MR"}, {"family": "Salvi", "given": "Daniele", "initials": "D"}, {"family": "Cacciari", "given": "Giulia", "initials": "G"}, {"family": "Kagramanova", "given": "Anna", "initials": "A"}, {"family": "Bordin", "given": "Dmitry", "initials": "D"}, {"family": "Drug", "given": "Vasile", "initials": "V"}, {"family": "Miftode", "given": "Edgidia", "initials": "E"}, {"family": "Fusaroli", "given": "Pietro", "initials": "P"}, {"family": "Mohamed", "given": "Salem Youssef", "initials": "SY"}, {"family": "Ricci", "given": "Chiara", "initials": "C"}, {"family": "Bellini", "given": "Massimo", "initials": "M"}, {"family": "Rahman", "given": "M Masudur", "initials": "MM"}, {"family": "Melcarne", "given": "Luigi", "initials": "L"}, {"family": "Santos", "given": "Javier", "initials": "J"}, {"family": "Lobo", "given": "Beatriz", "initials": "B"}, {"family": "Bor", "given": "Serhat", "initials": "S"}, {"family": "Yapali", "given": "Suna", "initials": "S"}, {"family": "Akyol", "given": "Deniz", "initials": "D"}, {"family": "Sapmaz", "given": "Ferdane Pirincci", "initials": "FP"}, {"family": "Urun", "given": "Yonca Yilmaz", "initials": "YY"}, {"family": "Eskazan", "given": "Tugce", "initials": "T"}, {"family": "Celebi", "given": "Altay", "initials": "A"}, {"family": "Kacmaz", "given": "Huseyin", "initials": "H"}, {"family": "Ebik", "given": "Berat", "initials": "B"}, {"family": "Binicier", "given": "Hatice Cilem", "initials": "HC"}, {"family": "Bugdayci", "given": "Mehmet Sait", "initials": "MS"}, {"family": "Ya\u011fc\u0131", "given": "Munkhtsetseg Banzragch", "initials": "MB"}, {"family": "Pullukcu", "given": "Husnu", "initials": "H"}, {"family": "Kaya", "given": "Berrin Yal\u0131nbas", "initials": "BY"}, {"family": "Tureyen", "given": "Ali", "initials": "A"}, {"family": "Hatemi", "given": "\u0130brahim", "initials": "\u0130"}, {"family": "Koc", "given": "Elif Sitre", "initials": "ES"}, {"family": "Sirin", "given": "Goktug", "initials": "G"}, {"family": "Cal\u0131skan", "given": "Ali Riza", "initials": "AR"}, {"family": "Bengi", "given": "Goksel", "initials": "G"}, {"family": "Al\u0131s", "given": "Esra Ergun", "initials": "EE"}, {"family": "Lukic", "given": "Snezana", "initials": "S"}, {"family": "Trajkovska", "given": "Meri", "initials": "M"}, {"family": "Hod", "given": "Keren", "initials": "K"}, {"family": "Dumitrascu", "given": "Dan", "initials": "D"}, {"family": "Pietrangelo", "given": "Antonello", "initials": "A"}, {"family": "Corradini", "given": "Elena", "initials": "E"}, {"family": "Simren", "given": "Magnus", "initials": "M"}, {"family": "Sjolund", "given": "Jessica", "initials": "J"}, {"family": "Tornkvist", "given": "Navkiran", "initials": "N"}, {"family": "Ghoshal", "given": "Uday C", "initials": "UC"}, {"family": "Kolokolnikova", "given": "Olga", "initials": "O"}, {"family": "Colecchia", "given": "Antonio", "initials": "A"}, {"family": "Serra", "given": "Jordi", "initials": "J"}, {"family": "Maconi", "given": "Giovanni", "initials": "G"}, {"family": "De Giorgio", "given": "Roberto", "initials": "R"}, {"family": "Danese", "given": "Silvio", "initials": "S"}, {"family": "Portincasa", "given": "Pietro", "initials": "P"}, {"family": "Di Stefano", "given": "Michele", "initials": "M"}, {"family": "Maggio", "given": "Marcello", "initials": "M"}, {"family": "Philippou", "given": "Elena", "initials": "E"}, {"family": "Lee", "given": "Yeong Yeh", "initials": "YY"}, {"family": "Venturi", "given": "Alessandro", "initials": "A"}, {"family": "Borghi", "given": "Claudio", "initials": "C"}, {"family": "Zoli", "given": "Marco", "initials": "M"}, {"family": "Gionchetti", "given": "Paolo", "initials": "P"}, {"family": "Viale", "given": "Pierluigi", "initials": "P"}, {"family": "Stanghellini", "given": "Vincenzo", "initials": "V"}, {"family": "Barbara", "given": "Giovanni", "initials": "G"}, {"family": "and the GI-COVID19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-09", "journal": {"title": "Am J Gastroenterol", "issn": "1572-0241", "issn-l": null}, "abstract": "Gastrointestinal (GI) symptoms in coronavirus-19 disease (COVID-19) have been reported with great variability and without standardization. In hospitalized patients, we aimed to evaluate the prevalence of GI symptoms, factors associated with their occurrence, and variation at 1 month.\n\nThe GI-COVID-19 is a prospective, multicenter, controlled study. Patients with and without COVID-19 diagnosis were recruited at hospital admission and asked for GI symptoms at admission and after 1 month, using the validated Gastrointestinal Symptom Rating Scale questionnaire.\n\nThe study included 2036 hospitalized patients. A total of 871 patients (575 COVID+ and 296 COVID-) were included for the primary analysis. GI symptoms occurred more frequently in patients with COVID-19 (59.7%; 343/575 patients) than in the control group (43.2%; 128/296 patients) (P < 0.001). Patients with COVID-19 complained of higher presence or intensity of nausea, diarrhea, loose stools, and urgency as compared with controls. At a 1-month follow-up, a reduction in the presence or intensity of GI symptoms was found in COVID-19 patients with GI symptoms at hospital admission. Nausea remained increased over controls. Factors significantly associated with nausea persistence in COVID-19 were female sex, high body mass index, the presence of dyspnea, and increased C-reactive protein levels.\n\nThe prevalence of GI symptoms in hospitalized patients with COVID-19 is higher than previously reported. Systemic and respiratory symptoms are often associated with GI complaints. Nausea may persist after the resolution of COVID-19 infection.", "doi": "10.14309/ajg.0000000000001541", "pmid": "34751672", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00000434-990000000-00142"}, {"db": "ClinicalTrials.gov", "key": "NCT04691895"}], "notes": [], "created": "2021-11-26T15:24:24.070Z", "modified": "2021-11-26T15:24:24.106Z"}, {"entity": "publication", "iuid": "2b4e6205c4f342c4805d41dd1d723a40", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b4e6205c4f342c4805d41dd1d723a40.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b4e6205c4f342c4805d41dd1d723a40"}}, "title": "Length of hospital stay and risk of intensive care admission and in-hospital death among COVID-19 patients in Norway: a register-based cohort study comparing patients fully vaccinated with an mRNA vaccine to unvaccinated patients", "authors": [{"family": "Whittaker", "given": "Robert", "initials": "R"}, {"family": "Br\u00e5then Kristofferson", "given": "Anja", "initials": "A"}, {"family": "Valcarcel Salamanca", "given": "Beatriz", "initials": "B"}, {"family": "Sepp\u00e4l\u00e4", "given": "Elina", "initials": "E"}, {"family": "Golestani", "given": "Karan", "initials": "K"}, {"family": "Kv\u00e5le", "given": "Reidar", "initials": "R"}, {"family": "Watle", "given": "Sara Viksmoen", "initials": "SV"}, {"family": "Buanes", "given": "Eirik Alnes", "initials": "EA"}], "type": "posted-content", "published": "2021-11-09", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.11.05.21265958", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2022-01-04T15:44:50.667Z", "modified": "2022-01-04T15:44:50.668Z"}, {"entity": "publication", "iuid": "93e4da7e9f8943779eb12a1d7d20110e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/93e4da7e9f8943779eb12a1d7d20110e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/93e4da7e9f8943779eb12a1d7d20110e"}}, "title": "COVID-19: What have we learned? What are the public health challenges?", "authors": [{"family": "Zeegers Paget", "given": "Dineke", "initials": "D"}, {"family": "Allebeck", "given": "Peter", "initials": "P", "orcid": "0000-0002-2778-6467", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de9f0e1c3e4d402b93e61ad1c5a771fb.json"}}, {"family": "Nagyova", "given": "Iveta", "initials": "I"}], "type": "journal-article", "published": "2021-11-09", "journal": {"title": "Eur J Public Health", "issn": "1101-1262", "volume": "31", "issue": "Supplement_4", "pages": "iv1-iv2", "issn-l": null}, "abstract": null, "doi": "10.1093/eurpub/ckab150", "pmid": "34751364", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8576293"}, {"db": "pii", "key": "6423460"}], "notes": [], "created": "2021-11-26T15:24:39.334Z", "modified": "2023-06-19T07:31:51.619Z"}, {"entity": "publication", "iuid": "acb1627ba8ce46d6923061af7507618b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/acb1627ba8ce46d6923061af7507618b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/acb1627ba8ce46d6923061af7507618b"}}, "title": "Advancing African Medicines Agency through Global Health Diplomacy for an Equitable Pan-African Universal Health Coverage: A Scoping Review.", "authors": [{"family": "Chattu", "given": "Vijay Kumar", "initials": "VK", "orcid": "0000-0001-9840-8335", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cebeeb53463e436e9ce1ffc57ec4a9b4.json"}}, {"family": "Dave", "given": "Vishal B", "initials": "VB", "orcid": "0000-0001-8099-1569", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0606a7312b9843c6ac11ba4e7440adc9.json"}}, {"family": "Reddy", "given": "K Srikanth", "initials": "KS"}, {"family": "Singh", "given": "Bawa", "initials": "B"}, {"family": "Sahiledengle", "given": "Biniyam", "initials": "B", "orcid": "0000-0002-1114-4849", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c434b82648f4f4c96d13e82c4a61ae1.json"}}, {"family": "Heyi", "given": "Demisu Zenbaba", "initials": "DZ"}, {"family": "Nattey", "given": "Cornelius", "initials": "C"}, {"family": "Atlaw", "given": "Daniel", "initials": "D", "orcid": "0000-0002-2968-4958", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f44d2cf7abb4db4affc9bad0e273cc7.json"}}, {"family": "Jackson", "given": "Kioko", "initials": "K"}, {"family": "El-Khatib", "given": "Ziad", "initials": "Z", "orcid": "0000-0003-0756-7280", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31747e0476314de9bf53d8c8f3d1d147.json"}}, {"family": "Eltom", "given": "Akram Ali", "initials": "AA"}], "type": "journal article", "published": "2021-11-09", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "22", "pages": null}, "abstract": "The African continent is home to 15% of the world's population and suffers from a disease burden of more than 25% globally. In this COVID-19 era, the high burden and mortality are further worsened due to inequities, inequalities such as inadequate health systems, scarce financial and human resources, as well as unavailability of inexpensive medicines of good quality, safety, and efficacy. The Universal Health Coverage ensures that people have access to high-quality essential health services, secure, reliable, and affordable essential medicines and vaccines, as well as financial security. This paper aimed at addressing the critical need for a continental African Medicines Agency (AMA) in addressing the inequities and the role of global health diplomacy in building consensus to support the ratification of the Treaty of AMA. A literature review was done in Scopus, Web of Science, MEDLINE/PubMed, and Google Scholar search engine to identify the critical literature in the context of study objectives. All the articles published after 2015 till 2021 in the context of AMA were included. African Health Strategy 2016-2030 highlighted the importance of an African regulatory mechanism for medicines and medical products. Through global health diplomacy (GHD), the African Union and its partners can negotiate and cooperate in providing infrastructural, administrative, and regulatory support for establishing the AMA. The paper emphasizes the South-South cooperation and highlights the contributions of India and China in the supply of medicines and vaccines to Africa. A strong AMA created through GHD can be a vital instrument in utilizing Trade-Related Aspects of Intellectual Property Rights (TRIPS) flexibilities extension and an ideal partner for European and other regional regulatory authorities seeking to stem the tide of counterfeit, sub-standard, or fake products.", "doi": "10.3390/ijerph182211758", "pmid": "34831511", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph182211758"}, {"db": "pmc", "key": "PMC8621302"}], "notes": [], "created": "2021-12-18T18:16:31.169Z", "modified": "2021-12-18T18:16:59.133Z"}, {"entity": "publication", "iuid": "210b5b5071e9404daef80cc8c61a3440", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/210b5b5071e9404daef80cc8c61a3440.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/210b5b5071e9404daef80cc8c61a3440"}}, "title": "Rapid and sensitive detection of SARS-CoV-2 infection using quantitative peptide enrichment LC-MS analysis.", "authors": [{"family": "Hober", "given": "Andreas", "initials": "A", "orcid": "0000-0001-8947-2562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20274f9e591044c1936d134df8a1950d.json"}}, {"family": "Tran-Minh", "given": "Khue Hua", "initials": "KH"}, {"family": "Foley", "given": "Dominic", "initials": "D"}, {"family": "McDonald", "given": "Thomas", "initials": "T"}, {"family": "Vissers", "given": "Johannes Pc", "initials": "JP"}, {"family": "Pattison", "given": "Rebecca", "initials": "R"}, {"family": "Ferries", "given": "Samantha", "initials": "S"}, {"family": "Hermansson", "given": "Sigurd", "initials": "S"}, {"family": "Betner", "given": "Ingvar", "initials": "I"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M"}, {"family": "Razavi", "given": "Morteza", "initials": "M"}, {"family": "Yip", "given": "Richard", "initials": "R"}, {"family": "Pope", "given": "Matthew E", "initials": "ME"}, {"family": "Pearson", "given": "Terry W", "initials": "TW"}, {"family": "Andersson", "given": "Leigh N", "initials": "LN"}, {"family": "Bartlett", "given": "Amy", "initials": "A"}, {"family": "Calton", "given": "Lisa", "initials": "L"}, {"family": "Alm", "given": "Jessica J", "initials": "JJ"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Edfors", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-0017-7987", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1908b42d06b74ee99706fb235d4bda90.json"}}], "type": "journal article", "published": "2021-11-08", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "10", "issn-l": null}, "abstract": "Reliable, robust, large-scale molecular testing for SARS-CoV-2 is essential for monitoring the ongoing Covid-19 pandemic. We have developed a scalable analytical approach to detect viral proteins based on peptide immunoaffinity enrichment combined with liquid chromatography - mass spectrometry (LC-MS). This is a multiplexed strategy, based on targeted proteomics analysis and read-out by LC-MS, capable of precisely quantifying and confirming the presence of SARS-CoV-2 in PBS swab media from combined throat/nasopharynx/saliva samples.<br />The results reveal that the levels of SARS-CoV-2 measured by LC-MS correlate well with their corresponding RT-PCR readout (r=0.79). The analytical workflow shows similar turnaround times as regular RT-PCR instrumentation with a quantitative readout of viral proteins corresponding to cycle thresholds (Ct) equivalents ranging from 21 to 34. Using RT-PCR as a reference, we demonstrate that the LC-MS-based method has 100% negative percent agreement (estimated specificity) and 95% positive percent agreement (estimated sensitivity) when analyzing clinical samples collected from asymptomatic individuals with a Ct within the limit of detection of the mass spectrometer (Ct \u226430). These results suggest that a scalable analytical method based on LC-MS has a place in future pandemic preparedness centers to complement current virus detection technologies.", "doi": "10.7554/eLife.70843", "pmid": "34747696", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "70843"}, {"db": "URL", "key": "http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD026366", "description": "PXD026366"}, {"db": "URL", "key": "https://panoramaweb.org/sars-cov-2_siscapa.url", "description": "https://panoramaweb.org/sars-cov-2_siscapa.url"}], "notes": [], "created": "2021-11-26T15:26:16.157Z", "modified": "2021-11-26T15:29:02.059Z"}, {"entity": "publication", "iuid": "07d46c6a5c20498da11b302b3193ee2c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07d46c6a5c20498da11b302b3193ee2c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07d46c6a5c20498da11b302b3193ee2c"}}, "title": "Poor outcome of patients with COVID-19 after CAR T-cell therapy for B-cell malignancies: results of a multicenter study on behalf of the European Society for Blood and Marrow Transplantation (EBMT) Infectious Diseases Working Party and the European Hematology Association (EHA) Lymphoma Group.", "authors": [{"family": "Spanjaart", "given": "Anne Mea", "initials": "AM"}, {"family": "Ljungman", "given": "Per", "initials": "P", "orcid": "0000-0002-8281-3245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4546eb504184683ab712eee858ea9cb.json"}}, {"family": "de La Camara", "given": "Rafael", "initials": "R", "orcid": "0000-0002-8189-5779", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/868bc0284ac640a1bf215e7d7cc86da3.json"}}, {"family": "Tridello", "given": "Gloria", "initials": "G"}, {"family": "Ortiz-Maldonado", "given": "Valent\u00edn", "initials": "V"}, {"family": "Urbano-Ispizua", "given": "Alvaro", "initials": "A"}, {"family": "Barba", "given": "Pere", "initials": "P", "orcid": "0000-0003-1038-5197", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e74c0f29540e4f59aa53f83fec63148f.json"}}, {"family": "Kwon", "given": "Mi", "initials": "M", "orcid": "0000-0002-3855-7774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04365251372d4a07bc1f72e2aaa487d1.json"}}, {"family": "Caballero", "given": "Dolores", "initials": "D"}, {"family": "Sesques", "given": "Pierre", "initials": "P"}, {"family": "Bachy", "given": "Emmanuel", "initials": "E"}, {"family": "Di Blasi", "given": "Roberta", "initials": "R"}, {"family": "Thieblemont", "given": "Catherine", "initials": "C"}, {"family": "Calkoen", "given": "Friso", "initials": "F", "orcid": "0000-0001-9059-0929", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3922445905394bcc810e480b12115a2c.json"}}, {"family": "Mutsaers", "given": "Pim", "initials": "P", "orcid": "0000-0002-3924-8578", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/abf9518b9408436ea710a959f84412af.json"}}, {"family": "Maertens", "given": "Johan", "initials": "J", "orcid": "0000-0003-4257-5980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4701b45871ba4030a2c57c01edcbf6e0.json"}}, {"family": "Giannoni", "given": "Livia", "initials": "L"}, {"family": "Nicholson", "given": "Emma", "initials": "E"}, {"family": "Collin", "given": "Matthew", "initials": "M", "orcid": "0000-0001-6585-9586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28e509d4da164f1d95963e649a3a6d78.json"}}, {"family": "Vaz", "given": "Carlos Pinho", "initials": "CP"}, {"family": "Metafuni", "given": "Elisabetta", "initials": "E"}, {"family": "Martinez-Lopez", "given": "Joaquin", "initials": "J"}, {"family": "Dignan", "given": "Fiona L", "initials": "FL"}, {"family": "Ribera", "given": "Josep-Maria", "initials": "JM"}, {"family": "Nagler", "given": "Arnon", "initials": "A"}, {"family": "Folber", "given": "Frantisek", "initials": "F"}, {"family": "Sanderson", "given": "Robin", "initials": "R"}, {"family": "Bloor", "given": "Adrian", "initials": "A", "orcid": "0000-0003-4550-220X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48157ff9b02f48b1878d9fea89853d4c.json"}}, {"family": "Ciceri", "given": "Fabio", "initials": "F"}, {"family": "Knelange", "given": "Nina", "initials": "N"}, {"family": "Ayuk", "given": "Francis", "initials": "F"}, {"family": "Kroger", "given": "Nicolaus", "initials": "N"}, {"family": "Kersten", "given": "Marie Jos\u00e9", "initials": "MJ"}, {"family": "Mielke", "given": "Stephan", "initials": "S", "orcid": "0000-0003-0167-6021", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b98a5979f3d4471bbbed5f392c31d1ce.json"}}], "type": "journal article", "published": "2021-11-08", "journal": {"title": "Leukemia", "issn": "1476-5551", "issn-l": null}, "abstract": null, "doi": "10.1038/s41375-021-01466-0", "pmid": "34750508", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41375-021-01466-0"}, {"db": "pmc", "key": "PMC8573311"}], "notes": [], "created": "2021-11-26T15:25:32.981Z", "modified": "2021-11-26T15:25:33.293Z"}, {"entity": "publication", "iuid": "2414e9421be64e729b4ecf0ff54aa539", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2414e9421be64e729b4ecf0ff54aa539.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2414e9421be64e729b4ecf0ff54aa539"}}, "title": "How an outbreak became a pandemic: a chronological analysis of crucial junctures and international obligations in the early months of the COVID-19 pandemic.", "authors": [{"family": "Singh", "given": "Sudhvir", "initials": "S"}, {"family": "McNab", "given": "Christine", "initials": "C"}, {"family": "Olson", "given": "Rose McKeon", "initials": "RM"}, {"family": "Bristol", "given": "Nellie", "initials": "N"}, {"family": "Nolan", "given": "Cody", "initials": "C"}, {"family": "Bergstr\u00f8m", "given": "Elin", "initials": "E"}, {"family": "Bartos", "given": "Michael", "initials": "M"}, {"family": "Mabuchi", "given": "Shunsuke", "initials": "S"}, {"family": "Panjabi", "given": "Raj", "initials": "R"}, {"family": "Karan", "given": "Abraar", "initials": "A"}, {"family": "Abdalla", "given": "Salma M", "initials": "SM"}, {"family": "Bonk", "given": "Mathias", "initials": "M"}, {"family": "Jamieson", "given": "Margaret", "initials": "M"}, {"family": "Werner", "given": "George K", "initials": "GK"}, {"family": "Nordstr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Legido-Quigley", "given": "Helena", "initials": "H"}, {"family": "Phelan", "given": "Alexandra", "initials": "A"}], "type": "journal article", "published": "2021-11-08", "journal": {"title": "Lancet", "issn": "1474-547X", "issn-l": "0140-6736"}, "abstract": "Understanding the spread of SARS-CoV-2, how and when evidence emerged, and the timing of local, national, regional, and global responses is essential to establish how an outbreak became a pandemic and to prepare for future health threats. With that aim, the Independent Panel for Pandemic Preparedness and Response has developed a chronology of events, actions, and recommendations, from December, 2019, when the first cases of COVID-19 were identified in China, to the end of March, 2020, by which time the outbreak had spread extensively worldwide and had been characterised as a pandemic. Datapoints are based on two literature reviews, WHO documents and correspondence, submissions to the Panel, and an expert verification process. The retrospective analysis of the chronology shows a dedicated initial response by WHO and some national governments, but also aspects of the response that could have been quicker, including outbreak notifications under the International Health Regulations (IHR), presumption and confirmation of human-to-human transmission of SARS-CoV-2, declaration of a Public Health Emergency of International Concern, and, most importantly, the public health response of many national governments. The chronology also shows that some countries, largely those with previous experience with similar outbreaks, reacted quickly, even ahead of WHO alerts, and were more successful in initially containing the virus. Mapping actions against IHR obligations, the chronology shows where efficiency and accountability could be improved at local, national, and international levels to more quickly alert and contain health threats in the future. In particular, these improvements include necessary reforms to international law and governance for pandemic preparedness and response, including the IHR and a potential framework convention on pandemic preparedness and response.", "doi": "10.1016/S0140-6736(21)01897-3", "pmid": "34762857", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)01897-3"}, {"db": "pmc", "key": "PMC8575464"}], "notes": [], "created": "2021-11-26T15:16:22.583Z", "modified": "2021-11-26T15:16:48.040Z"}, {"entity": "publication", "iuid": "26a045fa28384ae5abc4f75b80218a65", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26a045fa28384ae5abc4f75b80218a65.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26a045fa28384ae5abc4f75b80218a65"}}, "title": "COVID-19 and CAR-T cells: current challenges and future directions-a report from the EPICOVIDEHA survey by EHA-IDWP.", "authors": [{"family": "Busca", "given": "Alessandro", "initials": "A"}, {"family": "Salmanton-Garc\u00eda", "given": "Jon", "initials": "J", "orcid": "0000-0002-6766-8297", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dea501020d2042ad83d1b024987792f4.json"}}, {"family": "Corradini", "given": "Paolo", "initials": "P", "orcid": "0000-0002-9186-1353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d0e56ba864949b68f35a952b7d18036.json"}}, {"family": "Marchesi", "given": "Francesco", "initials": "F"}, {"family": "Cabirta", "given": "Alba", "initials": "A", "orcid": "0000-0001-7198-8894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ca8361c64eb4563a0f090faaf569e8a.json"}}, {"family": "Di Blasi", "given": "Roberta", "initials": "R", "orcid": "0000-0001-9001-573X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b0e256f42ad4d25aef901a2c2df7eab.json"}}, {"family": "Dulery", "given": "Remy", "initials": "R", "orcid": "0000-0002-5024-1713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e911a2d994434edbb736f77b7ccfcd72.json"}}, {"family": "Lamure", "given": "Sylvain", "initials": "S", "orcid": "0000-0001-5980-305X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0dc734a9a9e4016b2a1699809823fe2.json"}}, {"family": "Farina", "given": "Francesca", "initials": "F"}, {"family": "Weinbergerov\u00e1", "given": "Barbora", "initials": "B", "orcid": "0000-0001-6460-2471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7ef50b8f8dc457ab2badd8481b3fa86.json"}}, {"family": "Batini\u0107", "given": "Josip", "initials": "J"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Lopez-Garcia", "given": "Alberto", "initials": "A", "orcid": "0000-0002-5354-5261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c785356a67e4cbb9835fe9ce04a6153.json"}}, {"family": "Drgona", "given": "Lubos", "initials": "L", "orcid": "0000-0002-5089-3201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/746b17dbdf2a4b178e6a11454778c725.json"}}, {"family": "Espigado", "given": "Ildefonso", "initials": "I", "orcid": "0000-0002-4043-6613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40c943f7cd0e40998a4a1ae519a39e48.json"}}, {"family": "Falces-Romero", "given": "Iker", "initials": "I"}, {"family": "Garcia-Sanz", "given": "Ramon", "initials": "R", "orcid": "0000-0003-4120-2787", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8823f2241b74c59bac5fd3915041b1a.json"}}, {"family": "Garcia-Vidal", "given": "Carolina", "initials": "C", "orcid": "0000-0002-8915-0683", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d07f1141779e4aef88a4b126526d241e.json"}}, {"family": "Guidetti", "given": "Anna", "initials": "A"}, {"family": "Khanna", "given": "Nina", "initials": "N"}, {"family": "Kulesekararaj", "given": "Austin", "initials": "A", "orcid": "0000-0003-3180-3570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd4719161efc4d939fe6f4832430a1bc.json"}}, {"family": "Maertens", "given": "Johan", "initials": "J", "orcid": "0000-0003-4257-5980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4701b45871ba4030a2c57c01edcbf6e0.json"}}, {"family": "Hoenigl", "given": "Martin", "initials": "M", "orcid": "0000-0002-1653-2824", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f06a81d02454972bb9b64fea7c14dd4.json"}}, {"family": "Klimko", "given": "Nikolai", "initials": "N", "orcid": "0000-0001-6095-7531", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/da32e1ffe46c49f5a891df4e452b5ce7.json"}}, {"family": "Koehler", "given": "Philipp", "initials": "P"}, {"family": "Pagliuca", "given": "Antonio", "initials": "A"}, {"family": "Passamonti", "given": "Francesco", "initials": "F"}, {"family": "Cornely", "given": "Oliver", "initials": "O", "orcid": "0000-0001-9599-3137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3c62d8346924e69b6c99e4007c3831c.json"}}, {"family": "Pagano", "given": "Livio", "initials": "L", "orcid": "0000-0001-8287-928X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbf92a9779614910aeafcc6c21d880e2.json"}}], "type": "journal article", "published": "2021-11-08", "journal": {"title": "Blood Adv", "issn": "2473-9537", "issn-l": null}, "abstract": "Patients receiving chimeric antigen receptor T cells (CAR-T cells) therapy may be particularly susceptible to coronavirus disease 2019 (COVID-19) because of several factors including the immunosuppression associated to the underlying disease and delayed cytopenias. Regrettably, data on outcomes of CAR-T recipients with COVID-19 are extremely scarce. The aim of this study was to investigate the characteristics and outcomes of COVID-19 in patients treated with CAR-T therapy. The European Hematology Association - Scientific Working Group Infection in Hematology endorsed a survey to collect and analyze data from patients developing COVID-19 after CAR-T therapy. Overall, 459 patients treated with CAR-T cells were reported from 18 European centers. The prevalence of COVID-19 cases was 4.8%. Median time from CAR-T therapy and COVID-19 diagnosis was 169 days. Severe infection occurred in 66.7% of patients and 43.3% of the subjects required admission to ICU. The COVID-19 mortality was 33%. In multivariable analysis, the disease status at the time of COVID-19 trended marginally towards adverse outcome (P=0.075). In conclusion, we documented a high fatality rate for CAR-T patients with COVID-19, supporting the need to design successful interventions to mitigate the risk of infection in this vulnerable group of patients.", "doi": "10.1182/bloodadvances.2021005616", "pmid": "34749396", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "477883"}, {"db": "pmc", "key": "PMC8575532"}], "notes": [], "created": "2021-11-26T15:25:48.657Z", "modified": "2021-11-26T15:25:48.910Z"}, {"entity": "publication", "iuid": "c43d6c2225434e9f9fa38e7116ea1531", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c43d6c2225434e9f9fa38e7116ea1531.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c43d6c2225434e9f9fa38e7116ea1531"}}, "title": "Avian influenza, a new threat to public health in Europe?", "authors": [{"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Baldinelli", "given": "Francesca", "initials": "F"}, {"family": "Fusaro", "given": "Alice", "initials": "A"}, {"family": "Terregino", "given": "Calogero", "initials": "C"}], "type": "journal article", "published": "2021-11-08", "journal": {"title": "Clin Microbiol Infect", "issn": "1469-0691", "issn-l": null}, "abstract": "In our comment we outline the unprecedented situation on avian influenza virus in Europe and globally. We discuss the rapid emergence, diversification, global spread and impact of circulating avian influenza viruses of clade 2.3.4.4b in the light of increasing number of human cases globally and transmission events to other mammal species in Europe. Low levels of circulation of seasonal influenza due to the ongoing SARS-CoV-2 pandemic might hamper the early identification of human avian influenza cases due to lack of awareness or testing. This comment aims to raise awareness among clinicians, microbiologists and animal, public as well as occupational health experts about the ongoing threat of avian influenza viruses to human health also in Europe.", "doi": "10.1016/j.cmi.2021.11.005", "pmid": "34763057", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(21)00632-7"}], "notes": [], "created": "2021-11-26T15:15:47.163Z", "modified": "2021-11-26T15:15:57.578Z"}, {"entity": "publication", "iuid": "83ac762900b94d5e82d42f3f5d2a59e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/83ac762900b94d5e82d42f3f5d2a59e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/83ac762900b94d5e82d42f3f5d2a59e7"}}, "title": "Risk of hospitalization and risk of death for health care workers with COVID-19 in nine European countries, January 2020-January 2021.", "authors": [{"family": "Ferland", "given": "Lisa", "initials": "L"}, {"family": "Carvalho", "given": "Carlos", "initials": "C"}, {"family": "Dias", "given": "Joana Gomes", "initials": "JG"}, {"family": "Lamb", "given": "Favelle", "initials": "F"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Suetens", "given": "Carl", "initials": "C"}, {"family": "Beaut\u00e9", "given": "Julien", "initials": "J"}, {"family": "Kinross", "given": "Pete", "initials": "P"}, {"family": "Plachouras", "given": "Diamantis", "initials": "D"}, {"family": "Hannila-Handelberg", "given": "Tuula", "initials": "T"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "van Gageldonk-Lafeber", "given": "Rianne", "initials": "R"}, {"family": "Teirlinck", "given": "Anne C", "initials": "AC"}, {"family": "Mossong", "given": "Jo\u00ebl", "initials": "J"}, {"family": "Vergison", "given": "Anne", "initials": "A"}, {"family": "Melillo", "given": "Jackie", "initials": "J"}, {"family": "Melillo", "given": "Tanya", "initials": "T"}, {"family": "Mook", "given": "Piers", "initials": "P"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "Coutinho Rehse", "given": "Ana Paula", "initials": "AP"}, {"family": "Monnet", "given": "Dominique L", "initials": "DL"}], "type": "journal article", "published": "2021-11-06", "journal": {"title": "J Hosp Infect", "issn": "1532-2939", "issn-l": null}, "abstract": "We present and compare COVID-19 attack rates for infection, hospitalization, admission to intensive care unit (ICU), and death, in health care workers (HCW) and non-HCWs in nine European countries from 31 January 2020 to 13 January 2021. Adjusted attack rate ratios in HCWs (compared to non-HCWs) were 3.0 [95% confidence interval: 2.2-4.0] for infection, 1.8 [1.2-2.7] for hospitalization, 1.9 [1.1-3.2] for ICU admission and 0.9 [0.4-2.0] for death. Among hospitalized cases, case-fatality ratio was 1.8% in HCWs and 8.2% in non-HCWs. Differences might be due to better/earlier access to treatment, differential under-ascertainment, and to the healthy worker effect.", "doi": "10.1016/j.jhin.2021.10.015", "pmid": "34752802", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0195-6701(21)00379-0"}], "notes": [], "created": "2021-11-26T15:24:11.932Z", "modified": "2021-11-26T15:24:11.966Z"}, {"entity": "publication", "iuid": "1be19e040a094cac92dc986abf48c657", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1be19e040a094cac92dc986abf48c657.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1be19e040a094cac92dc986abf48c657"}}, "title": "Partner responsiveness moderates the relation between COVID-19-related stressors and changes in mood during the pandemic.", "authors": [{"family": "Soares", "given": "Lorrayne Stephane", "initials": "LS"}, {"family": "Rodrigues", "given": "Aliny Cristina", "initials": "AC"}, {"family": "de Paula", "given": "Jonas Jardim", "initials": "JJ"}, {"family": "Thorell", "given": "Lisa B", "initials": "LB"}, {"family": "de Miranda", "given": "Debora Marques", "initials": "DM"}], "type": "case reports", "published": "2021-11-06", "journal": {"title": "Curr Psychol", "issn": "1046-1310", "issn-l": null, "volume": null, "issue": null, "pages": "1-8"}, "abstract": "The COVID-19 pandemic has created an unusually stressful situation for many people around the world. Due to the restrictions, many have been isolated in their homes, and having a responsive partner may have become even more important. The present study aimed to investigate (1) whether there were any differences in social and work-related stressors and changes in negative mood during the COVID-19 pandemic as a function of marital status, and (2) whether perceived partner responsiveness can attenuate the associations between COVID-19-related stressors and changes in negative mood. The participants were 2,400 Brazilian adults recruited via the Internet, using a virtual sampling strategy. They were assigned to three distinct groups based on their relationship status. The results showed that a relatively large proportion of the sample reported increased levels of negative mood, and that married/cohabitating couples reported low levels of negative change in mood compared to single participants. We also found that partner responsiveness attenuated the association between stress and mental health, but only for people who were dating. Our study contributes new insights by showing that effects on mental health during the COVID-19 pandemic are dependent on relationship type and perceived partner responsiveness.", "doi": "10.1007/s12144-021-02429-5", "pmid": "34776716", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2429"}, {"db": "pmc", "key": "PMC8571670"}], "notes": [], "created": "2021-11-26T14:28:31.819Z", "modified": "2021-11-26T14:29:20.306Z"}, {"entity": "publication", "iuid": "280c373efc0a471f938e926d69a253f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/280c373efc0a471f938e926d69a253f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/280c373efc0a471f938e926d69a253f8"}}, "title": "Heart failure in type 2 diabetes: current perspectives on screening, diagnosis and management.", "authors": [{"family": "Ceriello", "given": "Antonio", "initials": "A", "orcid": "0000-0001-8122-3203", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1409105396004023a189c4ea96e0f410.json"}}, {"family": "Catrinoiu", "given": "Doina", "initials": "D"}, {"family": "Chandramouli", "given": "Chanchal", "initials": "C"}, {"family": "Cosentino", "given": "Francesco", "initials": "F"}, {"family": "Dombrowsky", "given": "Annique Cornelia", "initials": "AC"}, {"family": "Itzhak", "given": "Baruch", "initials": "B"}, {"family": "Lalic", "given": "Nebojsa Mali\u0107", "initials": "NM"}, {"family": "Prattichizzo", "given": "Francesco", "initials": "F"}, {"family": "Schnell", "given": "Oliver", "initials": "O"}, {"family": "Seferovi\u0107", "given": "Petar M", "initials": "PM"}, {"family": "Valensi", "given": "Paul", "initials": "P"}, {"family": "Standl", "given": "Eberhard", "initials": "E"}, {"family": "D&CVD EASD Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-06", "journal": {"title": "Cardiovasc Diabetol", "issn": "1475-2840", "volume": "20", "issue": "1", "pages": "218", "issn-l": null}, "abstract": "Type 2 diabetes is one of the most relevant risk factors for heart failure, the prevalence of which is increasing worldwide. The aim of the review is to highlight the current perspectives of the pathophysiology of heart failure as it pertains to type 2 diabetes. This review summarizes the proposed mechanistic bases, explaining the myocardial damage induced by diabetes-related stressors and other risk factors, i.e., cardiomyopathy in type 2 diabetes. We highlight the complex pathology of individuals with type 2 diabetes, including the relationship with chronic kidney disease, metabolic alterations, and heart failure. We also discuss the current criteria used for heart failure diagnosis and the gold standard screening tools for individuals with type 2 diabetes. Currently approved pharmacological therapies with primary use in type 2 diabetes and heart failure, and the treatment-guiding role of NT-proBNP are also presented. Finally, the influence of the presence of type 2 diabetes as well as heart failure on COVID-19 severity is briefly discussed.", "doi": "10.1186/s12933-021-01408-1", "pmid": "34740359", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12933-021-01408-1"}], "notes": [], "created": "2021-11-08T09:21:26.835Z", "modified": "2021-11-08T09:21:26.892Z"}, {"entity": "publication", "iuid": "a7133775d8e644d393d407b3da392cab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7133775d8e644d393d407b3da392cab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7133775d8e644d393d407b3da392cab"}}, "title": "Objective Assessment of Covid-19 Severity Affecting the Vocal and Respiratory System Using a Wearable, Autonomous Sound Collar.", "authors": [{"family": "Ishac", "given": "D", "initials": "D"}, {"family": "Matta", "given": "S", "initials": "S"}, {"family": "Bin", "given": "S", "initials": "S"}, {"family": "Aziz", "given": "H", "initials": "H"}, {"family": "Karam", "given": "E", "initials": "E"}, {"family": "Abche", "given": "A", "initials": "A"}, {"family": "Nassar", "given": "G", "initials": "G", "orcid": "0000-0002-8413-3307", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37be6a1d90b243f5ab4ca936d4537a2d.json"}}], "type": "journal article", "published": "2021-11-05", "journal": {"title": "Cell Mol Bioeng", "issn": "1865-5025", "pages": "1-20", "issn-l": null}, "abstract": "Since the outbreak began in January 2020, Covid-19 has affected more than 161 million people worldwide and resulted in about 3.3 million deaths. Despite efforts to detect human infection with the virus as early as possible, the confirmatory test still requires the analysis of sputum or blood with estimated results available within approximately 30 minutes; this may potentially be followed by clinical referral if the patient shows signs of aggravated pneumonia. This work aims to implement a soft collar as a sound device dedicated to the objective evaluation of the pathophysiological state resulting from dysphonia of laryngeal origin or respiratory failure of inflammatory origin, in particular caused by Covid-19.\n\nIn this study, we exploit the vibrations of waves generated by the vocal and respiratory system of 30 people. A biocompatible acoustic sensor embedded in a soft collar around the neck collects these waves. The collar is also equipped with thermal sensors and a cross-data analysis module in both the temporal and frequency domains (STFT). The optimal coupling conditions and the electrical and dimensional characteristics of the sensors were defined based on a mathematical approach using a matrix formalism.\n\nThe characteristics of the signals in the time domain combined with the quantities obtained from the STFT offer multidimensional information and a decision support tool for determining a pathophysiological state representative of the symptoms explored. The device, tested on 30 people, was able to differentiate patients with mild symptoms from those who had developed acute signs of respiratory failure on a severity scale of 1 to 10.\n\nWith the health constraints imposed by the effects of Covid-19, the heavy organization to be implemented resulting from the flow of diagnostics, tests and clinical management, it was urgent to develop innovative and safe biomedical technologies. This passive listening technique will contribute to the non-invasive assessment and dynamic observation of lesions. Moreover, it merits further examination to provide support for medical operators to improve clinical management.\n\nThe online version contains supplementary material available at 10.1007/s12195-021-00712-w.", "doi": "10.1007/s12195-021-00712-w", "pmid": "34777597", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "712"}, {"db": "pmc", "key": "PMC8570400"}], "notes": [], "created": "2021-11-26T14:27:31.945Z", "modified": "2021-11-26T14:27:32.026Z"}, {"entity": "publication", "iuid": "2e52c172c947474e89a0f1ab9da80a78", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e52c172c947474e89a0f1ab9da80a78.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e52c172c947474e89a0f1ab9da80a78"}}, "title": "Internet addiction and sleep quality among medical students during the COVID-19 pandemic: A multinational cross-sectional survey.", "authors": [{"family": "Tahir", "given": "Muhammad Junaid", "initials": "MJ"}, {"family": "Malik", "given": "Najma Iqbal", "initials": "NI", "orcid": "0000-0002-3521-1014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c17242b513143b18e3bb8108f009ca4.json"}}, {"family": "Ullah", "given": "Irfan", "initials": "I", "orcid": "0000-0003-1100-101X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8d5a7e15ae6487cbdda0de3b2a531c3.json"}}, {"family": "Khan", "given": "Hamza Rafique", "initials": "HR"}, {"family": "Perveen", "given": "Shahida", "initials": "S"}, {"family": "Ramalho", "given": "Rodrigo", "initials": "R"}, {"family": "Siddiqi", "given": "Ahsun Rizwan", "initials": "AR", "orcid": "0000-0003-4699-6221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a86efce9fcb4b8d8e3563d416b5fe83.json"}}, {"family": "Waheed", "given": "Summaiya", "initials": "S", "orcid": "0000-0003-1199-3039", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c767edcc9e1940ccb289fa8063ba7c98.json"}}, {"family": "Shalaby", "given": "Mahmoud Mohamed Mohamed", "initials": "MMM", "orcid": "0000-0001-7237-4616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51ae61a95e0243438b5603032c6bc49b.json"}}, {"family": "De Berardis", "given": "Domenico", "initials": "D"}, {"family": "Jain", "given": "Samiksha", "initials": "S"}, {"family": "Vetrivendan", "given": "Gautham Lakshmipriya", "initials": "GL"}, {"family": "Chatterjee", "given": "Harshita", "initials": "H"}, {"family": "Gopar Franco", "given": "William Xochitun", "initials": "WX"}, {"family": "Shafiq", "given": "Muhammad Ahsan", "initials": "MA", "orcid": "0000-0002-2255-4544", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb7c68b72c2a424c8dacee6414d5fb07.json"}}, {"family": "Fatima", "given": "Naira Taiba", "initials": "NT"}, {"family": "Abeysekera", "given": "Maria", "initials": "M", "orcid": "0000-0002-3222-5402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47aee02b846743a4aa205920b66b045a.json"}}, {"family": "Sayyeda", "given": "Qudsia", "initials": "Q"}, {"family": "Shamat", "given": "Shamat Fathi", "initials": "SF"}, {"family": "Aiman", "given": "Wajeeha", "initials": "W", "orcid": "0000-0001-8306-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef22926250924ef3af43732b663197e6.json"}}, {"family": "Akhtar", "given": "Qirat", "initials": "Q"}, {"family": "Devi", "given": "Arooj", "initials": "A"}, {"family": "Aftab", "given": "Anam", "initials": "A"}, {"family": "Shoib", "given": "Sheikh", "initials": "S"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-11-05", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "11", "pages": "e0259594", "issn-l": "1932-6203"}, "abstract": "The emergence of the COVID-19 pandemic has affected the lives of many people, including medical students. The present study explored internet addiction and changes in sleep patterns among medical students during the pandemic and assessed the relationship between them.\n\nA cross-sectional study was carried out in seven countries, the Dominican Republic, Egypt, Guyana, India, Mexico, Pakistan, and Sudan, using a convenience sampling technique, an online survey comprising demographic details, information regarding COVID-19, the Pittsburgh Sleep Quality Index (PSQI), and the Internet Addiction Test (IAT).\n\nIn total, 2749 participants completed the questionnaire. Of the total, 67.6% scored above 30 in the IAT, suggesting the presence of an Internet addiction, and 73.5% scored equal and above 5 in the PSQI, suggesting poor sleep quality. Internet addiction was found to be significant predictors of poor sleep quality, causing 13.2% of the variance in poor sleep quality. Participants who reported COVID-19 related symptoms had disturbed sleep and higher internet addiction levels when compared with those who did not. Participants who reported a diagnosis of COVID-19 reported poor sleep quality. Those living with a COVID-19 diagnosed patient reported higher internet addiction and worse sleep quality compared with those who did not have any COVID-19 patients in their surroundings.\n\nThe results of this study suggest that internet addiction and poor sleep quality are two issues that require addressing amongst medical students. Medical training institutions should do their best to minimize their negative impact, particularly during the current COVID-19 pandemic.", "doi": "10.1371/journal.pone.0259594", "pmid": "34739502", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-19421"}, {"db": "pmc", "key": "PMC8570473"}], "notes": [], "created": "2021-11-08T09:20:03.775Z", "modified": "2021-11-26T15:37:15.553Z"}, {"entity": "publication", "iuid": "8f20f3230f124a80863085063aa508b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f20f3230f124a80863085063aa508b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f20f3230f124a80863085063aa508b4"}}, "title": "Gastrointestinal Manifestations and Possible Mechanisms of COVID-19 in Different Periods.", "authors": [{"family": "Zhang", "given": "Mengmeng", "initials": "M"}, {"family": "Chen", "given": "Luni", "initials": "L"}, {"family": "Qian", "given": "Jiaming", "initials": "J", "orcid": "0000-0001-6611-9475", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/97782f236bdb4f5db68af8f464f1634c.json"}}], "type": "journal article", "published": "2021-11-05", "journal": {"title": "J Dig Dis", "issn": "1751-2980", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19), as a new infectious disease, has spread worldwide. COVID-19 mainly impacts respiratory system, but digestive manifestations have been frequently described in COVID-19 cases as well, even as the initial symptoms. And there have been several reports about the different gastrointestinal (GI) manifestations in mild and severe patients or in remission stages. So it is reasonable to consult that GI symptoms have distinct characteristics in different periods of COVID-19. Therefore, this review article will try to summarize the gastrointestinal manifestations and possible mechanisms of COVID-19 in different periods, and explain the significance of gastrointestinal manifestations in systemic inflammatory injury. This article is protected by copyright. All rights reserved.", "doi": "10.1111/1751-2980.13065", "pmid": "34738727", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-11-08T09:19:20.920Z", "modified": "2021-11-26T15:39:49.918Z"}, {"entity": "publication", "iuid": "32ee20e91fb54cbd8899a8b1077d4d67", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/32ee20e91fb54cbd8899a8b1077d4d67.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/32ee20e91fb54cbd8899a8b1077d4d67"}}, "title": "Physical Function, Cognitive Function, and Daily Activities in Patients Hospitalized Due to COVID-19: A Descriptive Cross-Sectional Study in Sweden.", "authors": [{"family": "Larsson", "given": "Alexandra C", "initials": "AC", "orcid": "0000-0001-9100-4071", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8532302825d744c7b29ccefeb16e11e2.json"}}, {"family": "Palstam", "given": "Annie", "initials": "A"}, {"family": "Persson", "given": "Hanna C", "initials": "HC", "orcid": "0000-0001-8633-3292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc8035c749ab4521b549ea820f6b4389.json"}}], "type": "journal article", "published": "2021-11-04", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "21", "issn-l": null}, "abstract": "An estimated 14-20% of people infected with COVID-19 require medical care. The aim of the present study was to evaluate physical function, cognitive function, and daily activities in patients hospitalized due to COVID-19, and to investigate differences depending on age and admission to the intensive care unit (ICU). This prospective descriptive cross-sectional study included a consecutive sample of 211 patients (mean age 65.1 years, 67.3% men) hospitalized due to COVID-19 in Sweden. Data regarding physical function and daily activities were collected in hospital from July 2020 to February 2021. The average length of hospital stay was 33.8 days, and 48.8% of the patients were admitted to the ICU. Physical function (grip- and lower body strength) was reduced in both groups, and significantly more in the older group, \u226565 years old, compared to the younger. Furthermore, the older group also had significantly less ability to perform activities in daily life, and had significantly reduced cognitive function as compared to the younger age group. In patients treated in the ICU, physical impairments as well as the activity level were significantly more pronounced compared to patients not treated in the ICU. Patients hospitalized due to COVID-19 are physically impaired, have mild cognitive impairments, and have difficulties performing daily activities. The findings in this study indicate the need for out-patient follow-up and rehabilitation for patients hospitalized due to COVID-19, especially in older patients and patients treated in the ICU.", "doi": "10.3390/ijerph182111600", "pmid": "34770113", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182111600"}, {"db": "pmc", "key": "PMC8582899"}], "notes": [], "created": "2021-11-26T15:08:28.992Z", "modified": "2021-11-26T15:08:29.085Z"}, {"entity": "publication", "iuid": "c527b9a6aa9c4e09857d147f3a39a164", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c527b9a6aa9c4e09857d147f3a39a164.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c527b9a6aa9c4e09857d147f3a39a164"}}, "title": "Digital Entry-Level Education in Physiotherapy: a Commentary to Inform Post-COVID-19 Future Directions.", "authors": [{"family": "Rossettini", "given": "Giacomo", "initials": "G", "orcid": "0000-0002-1623-7681", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a762502a2851423abc3f64ebc500eb2f.json"}}, {"family": "Turolla", "given": "Andrea", "initials": "A", "orcid": "0000-0002-1609-8060", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02bc8df4293942a6bb90e78787e347e7.json"}}, {"family": "Gudjonsdottir", "given": "Bjorg", "initials": "B", "orcid": "0000-0003-4566-9333", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/082e09793ae7433796603a7352364699.json"}}, {"family": "Kapreli", "given": "Eleni", "initials": "E", "orcid": "0000-0001-6752-427X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44e98c8f41f042b2834bc757fbefa1ee.json"}}, {"family": "Salchinger", "given": "Beate", "initials": "B", "orcid": "0000-0003-2132-5384", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bad611449f04d4382fec7dfc8f1785e.json"}}, {"family": "Verheyden", "given": "Geert", "initials": "G", "orcid": "0000-0003-3095-8175", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19a2c35a537e4483923467fa8ecef9ab.json"}}, {"family": "Palese", "given": "Alvisa", "initials": "A", "orcid": "0000-0002-3508-844X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea400153bf344f98a5e06367b0442e17.json"}}, {"family": "Dell'Isola", "given": "Andrea", "initials": "A", "orcid": "0000-0002-0319-458X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d8ea417b7c447f8bc4da9f47f9feb39.json"}}, {"family": "de Caro", "given": "John Xerri", "initials": "JX", "orcid": "0000-0003-1198-1660", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aaa4c4a9eeb24a01af410608a82465da.json"}}], "type": "editorial", "published": "2021-11-04", "journal": {"title": "Med Sci Educ", "issn": "2156-8650", "pages": "1-13", "issn-l": null}, "abstract": "Currently, the coronavirus disease 2019 (COVID-19) severely influences physiotherapy education which is based mostly on face-to-face teaching. Thus, educators have been compelled to adapt their pedagogical approaches moving to digital education. In this commentary, we debate on digital education highlighting its effectiveness, the users' perspectives, and its weakness in the context of physiotherapy teaching aimed at informing post-COVID-19 future directions in this educational field. Existing evidence on digital education produced before COVID-19 supports its implementation into entry-level physiotherapy education. However, some challenges (e.g. social inequality and evaluation of students) threaten its applicability in post-COVID-19 era, calling educators to take appropriate actions.", "doi": "10.1007/s40670-021-01439-z", "pmid": "34754600", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "1439"}, {"db": "pmc", "key": "PMC8567978"}], "notes": [], "created": "2021-11-26T15:23:41.362Z", "modified": "2021-11-26T15:23:50.633Z"}, {"entity": "publication", "iuid": "862d1ff1e9f6423da651586d40730006", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/862d1ff1e9f6423da651586d40730006.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/862d1ff1e9f6423da651586d40730006"}}, "title": "Whole-Blood DNA Methylation Analysis Reveals Respiratory Environmental Traits Involved in COVID-19 Severity Following SARS-CoV-2 Infection", "authors": [{"family": "Barturen", "given": "Guillermo", "initials": "G", "orcid": "0000-0003-2103-1028", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a338918e305480497c4e51b5874dd52.json"}}, {"family": "Carnero-Montoro", "given": "Elena", "initials": "E"}, {"family": "Mart\u00ednez-Bueno", "given": "Manuel", "initials": "M"}, {"family": "Rojo-Rello", "given": "Silvia", "initials": "S"}, {"family": "Sobrino", "given": "Beatriz", "initials": "B"}, {"family": "Alc\u00e1ntara-Dom\u00ednguez", "given": "Clara", "initials": "C"}, {"family": "Bernardo", "given": "David", "initials": "D"}, {"family": "Alarc\u00f3n-Riquelme", "given": "Marta E", "initials": "ME"}], "type": "posted-content", "published": "2021-11-03", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.11.03.21260184", "pmid": null, "labels": {"Category: Health": null, "Type: Preprint": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-11-08T09:24:08.423Z", "modified": "2021-11-08T09:24:08.467Z"}, {"entity": "publication", "iuid": "0adda81270ec4cc89f61c155e06af98d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0adda81270ec4cc89f61c155e06af98d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0adda81270ec4cc89f61c155e06af98d"}}, "title": "Telephone-based behavioral activation with mental imagery for depression: A pilot randomized clinical trial in isolated older adults during the Covid-19 pandemic.", "authors": [{"family": "Pellas", "given": "Johnny", "initials": "J", "orcid": "0000-0002-0707-0832", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b194cea3f31a427b99b5dadcc7ab378d.json"}}, {"family": "Renner", "given": "Fritz", "initials": "F"}, {"family": "Ji", "given": "Julie L", "initials": "JL"}, {"family": "Damberg", "given": "Mattias", "initials": "M"}], "type": "journal article", "published": "2021-11-03", "journal": {"title": "Int J Geriatr Psychiatry", "issn": "1099-1166", "issn-l": null}, "abstract": "To shield vulnerable persons, particularly the elderly, during the Covid-19 pandemic governments around the world have advised to use social distancing and self-isolation. Social isolation might put older adults at an increased risk for mental health problems such as depression. There is a need for brief, easy-accessible psychological treatments for depressive symptoms that can be delivered remotely. The aim of this study was to investigate the feasibility, acceptability, and preliminary efficacy of telephone-delivered Behavioral Activation with Mental Imagery (BA-MI) for the treatment of depressive symptoms in individuals 65 years and older living in isolation during the Covid-19 pandemic.\n\nIn this open-label pilot randomized clinical trial, N = 41 individuals aged 65 years or older with clinically significant symptoms of depression were randomly assigned to either a BA-MI treatment condition, or an Attention-Assessment control condition delivered over the telephone over a 4-week period.\n\nDepressive symptoms decreased more in the treatment condition compared to the control condition. At post-treatment, 2 out of 16 participants in the treatment condition met diagnostic criteria for depression compared to 9 out of 13 in the control condition. Most participants in the treatment condition were satisfied with the treatment and few adverse effects were observed.\n\nThis pilot study suggests that behavioral activation with mental imagery delivered over the telephone is feasible, acceptable, and potentially efficacious for the treatment of depressive symptoms in older individuals living in isolation. Replication in larger samples is needed.", "doi": "10.1002/gps.5646", "pmid": "34729823", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T15:41:40.865Z", "modified": "2021-11-26T15:41:40.938Z"}, {"entity": "publication", "iuid": "41c5838635aa470197d9531080584fbb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41c5838635aa470197d9531080584fbb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41c5838635aa470197d9531080584fbb"}}, "title": "Changes in Self-Reported Web-Based Gambling Activity During the COVID-19 Pandemic: Cross-sectional Study.", "authors": [{"family": "Claesdotter-Knutsson", "given": "Emma", "initials": "E", "orcid": "0000-0002-6832-2482", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8738736985b40b3bdf49061f734f62f.json"}}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A", "orcid": "0000-0002-5800-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec14ecdcc0654d8ea864f64ce195752b.json"}}], "type": "journal article", "published": "2021-11-03", "journal": {"title": "JMIR Serious Games", "issn": "2291-9279", "volume": "9", "issue": "4", "pages": "e30747", "issn-l": null}, "abstract": "The COVID\u201119 pandemic has affected not only somatic health with over 3.7 million deaths worldwide, but also has had a huge impact on psychological health, creating what amounts to a mental health crisis. The negative effect of the pandemic on traditional addictions is well described and concerning, and the same has been seen for gambling.\n\nThis study explores self-reported web-based gambling behavior during the COVID\u201119 pandemic in Sweden. We investigated overall changes, but also changes in specific web-based gambling types, and whether they are associated with certain risk factors or lifestyle changes.\n\nOur study is based on an anonymous web-based survey of web panel participants in Sweden (N=1501) designed to study a range of behavioral changes during the COVID\u201119 pandemic. Increases in gambling were analyzed using logistic regression models against sociodemographic data and psychological distress.\n\nThe majority of the respondents who gambled reported no changes in their gambling habits during the COVID\u201119 pandemic. We found significant associations with the problem gambling severity index (PGSI), the Kessler score (indicating psychological distress), employment status, changes in alcohol habits, and self-exclusion when looking at overall changes in gambling activity in the pandemic. In the subgroup that reported an increase in gambling activity, we found an association with both the PGSI and Kessler scores. The PGSI score was also an independent predictor for all specific web-based gambling (horses, sports, poker, and casino) whereas the Kessler score only had a significant impact on changes in casino gambling. In addition, male gender was an independent predictor for gambling on sports and casino gambling.\n\nThe majority of respondents who gambled reported no changes in their gambling activity during the COVID\u201119 pandemic. The group that reported an increase in overall gambling activity during the COVID-19 pandemic represent a group with gambling problems and psychological distress. The group that reported increased sports and casino gambling were often male, and this group seemed to experience more psychological distress.", "doi": "10.2196/30747", "pmid": "34730540", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "v9i4e30747"}, {"db": "pmc", "key": "PMC8568044"}], "notes": [], "created": "2021-11-08T09:15:10.855Z", "modified": "2021-11-26T15:41:19.258Z"}, {"entity": "publication", "iuid": "5bcd844252e14ddfae807c3083021b97", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5bcd844252e14ddfae807c3083021b97.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5bcd844252e14ddfae807c3083021b97"}}, "title": "Changes in Mental Health and Views on Communication and Activities of Public Institutions among Swedes during the COVID-19 Pandemic-A Cross-Sectional Repeated Measures Design.", "authors": [{"family": "Kerstis", "given": "Birgitta", "initials": "B", "orcid": "0000-0003-0242-0343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b50ad01a7fdd43b589b7ec07cf98f220.json"}}, {"family": "Giannotta", "given": "Fabrizia", "initials": "F"}, {"family": "W\u00e5gert", "given": "Petra von Heideken", "initials": "PVH", "orcid": "0000-0001-6292-7010", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4d6dfb26a37419385eb8e257f89d950.json"}}, {"family": "Hellstr\u00f6m", "given": "Charlotta", "initials": "C", "orcid": "0000-0003-1675-4408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a211ac4b50f24a3ca7be0deb42bc3362.json"}}, {"family": "Lindberg", "given": "Daniel", "initials": "D", "orcid": "0000-0002-8541-1727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f40c1556e4545a3a69893d276425af9.json"}}, {"family": "Stier", "given": "Jonas", "initials": "J"}, {"family": "Elv\u00e9n", "given": "Maria", "initials": "M", "orcid": "0000-0001-5356-916X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d90589956db4920b99e166ed4c6dfb2.json"}}], "type": "journal article", "published": "2021-11-03", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "volume": "9", "issue": "11", "issn-l": null}, "abstract": "Although many studies have been conducted on the effects of COVID-19 on individual lives, only a few focus on the changes in mental health and views of public institutions during the pandemic. This study aimed to investigate how mental health, i.e., life satisfaction, worries, and psychological distress, and views on public institutions' communication and activities have changed among Swedes during the COVID-19 pandemic, and whether this was moderated by age and sex. In April-May 2020 (survey 1) and in January-February 2021 (survey 2), 2554 adults and 1904 newly recruited adults, respectively, anonymously completed online surveys. We found that life satisfaction and psychological distress did not change from survey 1 to survey 2. However, the level of worries increased, and the positive views of the public institutions decreased. Moreover, worries and psychological distress increased more in young adults than older adults. Finally, the change in the views of the public institutions was not related to the change in worries. Our results highlight the COVID-19 long-term impacts on individual mental health and call for the need for future research concerning the consequences for the population, especially among young adults. The results also indicate that the views on activities of public authorities decreased over time, especially among men. Given that loss of this trust can have vastly negative effects, for instance, on the vaccine campaign, it is important to monitor this trend, to increase awareness among Swedish authorities. The results also stress for institutions to provide adequate support both during the COVID-19 pandemic and in a future crisis.", "doi": "10.3390/healthcare9111498", "pmid": "34828544", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "healthcare9111498"}, {"db": "pmc", "key": "PMC8625226"}], "notes": [], "created": "2021-12-18T18:17:09.585Z", "modified": "2021-12-18T18:17:15.382Z"}, {"entity": "publication", "iuid": "d6f9488ca04245678ffcb70d7f6bd3e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d6f9488ca04245678ffcb70d7f6bd3e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d6f9488ca04245678ffcb70d7f6bd3e7"}}, "title": "Rolling Circle Amplification in Integrated Microsystems: An Uncut Gem toward Massively Multiplexed Pathogen Diagnostics and Genotyping.", "authors": [{"family": "Soares", "given": "Ruben R G", "initials": "RRG", "orcid": "0000-0001-5958-5232", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2fc2815bc25c4fb78df63294947ee184.json"}}, {"family": "Madaboosi", "given": "Narayanan", "initials": "N"}, {"family": "Nilsson", "given": "Mats", "initials": "M", "orcid": "0000-0001-9985-0387", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/797aac5da3e9472a98af20d637d89784.json"}}], "type": "journal article", "published": "2021-11-02", "journal": {"title": "Acc Chem Res", "issn": "1520-4898", "issn-l": null, "volume": "54", "issue": "21", "pages": "3979-3990"}, "abstract": "The development of robust methods allowing the precise detection of specific nucleic acid sequences is of major societal relevance, paving the way for significant advances in biotechnology and biomedical engineering. These range from a better understanding of human disease at a molecular level, allowing the discovery and development of novel biopharmaceuticals and vaccines, to the improvement of biotechnological processes providing improved food quality and safety, efficient green fuels, and smart textiles. Among these applications, the significance of pathogen diagnostics as the main focus of this Account has become particularly clear during the recent SARS-CoV-2 pandemic. In this context, while RT-PCR is the gold standard method for unambiguous detection of genetic material from pathogens, other isothermal amplification alternatives circumventing rapid heating-cooling cycles up to \u223c95 \u00b0C are appealing to facilitate the translation of the assay into point-of-care (PoC) analytical platforms. Furthermore, the possibility of routinely multiplexing the detection of tens to hundreds of target sequences with single base pair specificity, currently not met by state-of-the-art methods available in clinical laboratories, would be instrumental along the path to tackle emergent viral variants and antimicrobial resistance genes. Here, we advocate that padlock probes (PLPs), first reported by Nilsson et al. in 1994, coupled with rolling circle amplification (RCA), termed here as PLP-RCA, is an underexploited technology in current arena of isothermal nucleic acid amplification tests (NAATs) providing an unprecedented degree of multiplexing, specificity, versatility, and amenability to integration in miniaturized PoC platforms. Furthermore, the intrinsically digital amplification of PLP-RCA retains spatial information and opens new avenues in the exploration of pathogenesis with spatial multiomics analysis of infected cells and tissue.The Account starts by introducing PLP-RCA in a nutshell focusing individually on the three main assay steps, namely, (1) PLP design and ligation mechanism, (2) RCA after probe ligation, and (3) detection of the RCA products. Each subject is touched upon succinctly but with sufficient detail for the reader to appreciate some assay intricacies and degree of versatility depending on the analytical challenge at hand. After familiarizing the reader with the method, we discuss specific examples of research in our group and others using PLP-RCA for viral, bacterial, and fungal diagnostics in a variety of clinical contexts, including the genotyping of antibiotic resistance genes and viral subtyping. Then, we dissect key developments in the miniaturization and integration of PLP-RCA to minimize user input, maximize analysis throughput, and expedite the time to results, ultimately aiming at PoC applications. These developments include molecular enrichment for maximum sensitivity, spatial arrays to maximize analytical throughput, automation of liquid handling to streamline the analytical workflow in miniaturized devices, and seamless integration of signal transduction to translate RCA product titers (and ideally spatial information) into a readable output. Finally, we position PLP-RCA in the current landscape of NAATs and furnish a systematic Strengths, Weaknesses, Opportunities and Threats analysis to shine light upon unpolished edges to uncover the gem with potential for ubiquitous, precise, and unbiased pathogen diagnostics.", "doi": "10.1021/acs.accounts.1c00438", "pmid": "34637281", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC8567418"}], "notes": [], "created": "2021-10-21T05:29:45.915Z", "modified": "2021-12-07T10:01:21.291Z"}, {"entity": "publication", "iuid": "7c8fb306e45e4631a707195122800f01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7c8fb306e45e4631a707195122800f01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7c8fb306e45e4631a707195122800f01"}}, "title": "Management of personal protective equipment during the COVID-19 pandemic in England and the state of New York: A comparative case study.", "authors": [{"family": "Barber", "given": "Amy", "initials": "A"}, {"family": "Vinzent", "given": "Anna\u00eblle", "initials": "A"}, {"family": "Williams", "given": "Imani", "initials": "I"}], "type": "journal article", "published": "2021-11-02", "journal": {"title": "J Emerg Manag", "issn": "1543-5865", "issn-l": null, "volume": "18", "issue": "7", "pages": "71-89"}, "abstract": "The COVID-19 crisis placed extraordinary demands on the supply of personal protective equipment (PPE) at the beginning of 2020. These were coupled with shocks to the supply chain resulting from the disease. Many typically well-resourced health systems faced subsequent shortages of equipment and had to implement new strategies to manage their stocks. Stockpiles of protective equipment were held in both the United States and United Kingdom intended to prevent shortages.\r\n\r\nCross-comparative case study approach by applying Pettigrew and Whipp's framework for change management.\r\n\r\nThe health systems of England and New York state from January 2020 to the end of April 2020.\r\n\r\nBoth cases reacted slowly to their outbreaks and faced problems with supplying enough PPE to their health systems. Their stockpiles were not enough to prevent shortages, with many distribution problems resulting from inadequate governance mechanisms. No sustainable responses to supply disruptions were implemented during the study period in either case. Health systems planned interventions along each part of the supply chain from production and importing, to usage guidelines.\r\n\r\nGlobal supply chains are vulnerable to disruptions caused by international crises, and existing mitigation strategies have not been wholly successful. The existence of stockpiles is insufficient to preventing shortages of necessary equipment in clinical settings. Both the governance and quality of stockpiles, as well as distribution channels are important for preventing shortages. At the time of writing, it is not possible to judge the strength of strategies adopted in these cases.", "doi": "10.5055/jem.0531", "pmid": "34723349", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "jem.0531"}], "notes": [], "created": "2021-11-02T15:44:29.443Z", "modified": "2021-11-02T15:45:06.409Z"}, {"entity": "publication", "iuid": "a7e380d43e2a49ae9d45952a3a365992", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7e380d43e2a49ae9d45952a3a365992.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7e380d43e2a49ae9d45952a3a365992"}}, "title": "Longitudinal Follow Up of Immune Responses to SARS-CoV-2 in Health Care Workers in Sweden With Several Different Commercial IgG-Assays, Measurement of Neutralizing Antibodies and CD4+ T-Cell Responses.", "authors": [{"family": "Marklund", "given": "Emelie", "initials": "E"}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Lundgren", "given": "Anna", "initials": "A"}, {"family": "Liljeqvist", "given": "Jan-\u00c5ke", "initials": "J\u00c5"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Bemark", "given": "Mats", "initials": "M"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-11-02", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "12", "issue": null, "pages": "750448"}, "abstract": "The risk of SARS-CoV-2 infection among health care workers (HCWs) is a concern, but studies that conclusively determine whether HCWs are over-represented remain limited. Furthermore, methods used to confirm past infection vary and the immunological response after mild COVID-19 is still not well defined.\n\n314 HCWs were recruited from a Swedish Infectious Diseases clinic caring for COVID-19 patients. IgG antibodies were measured using two commercial assays (Abbot Architect nucleocapsid (N)-assay and YHLO iFlash-1800 N and spike (S)-assays) at five time-points, from March 2020 to January 2021, covering two pandemic waves. Seroprevalence was assessed in matched blood donors at three time-points. More extensive analyses were performed in 190 HCWs in September/October 2020, including two additional IgG-assays (DiaSorin LiaisonXL S1/S2 and Abbot Architect receptor-binding domain (RBD)-assays), neutralizing antibodies (NAbs), and CD4+ T-cell reactivity using an in-house developed in vitro whole-blood assay based on flow cytometric detection of activated cells after stimulation with Spike S1-subunit or Spike, Membrane and Nucleocapsid (SMN) overlapping peptide pools.\n\nSeroprevalence was higher among HCWs compared to sex and age-matched blood donors at all time-points. Seropositivity increased from 6.4% to 16.3% among HCWs between May 2020 and January 2021, compared to 3.6% to 11.9% among blood donors. We found significant correlations and high levels of agreement between NAbs and all four commercial IgG-assays. At 200-300 days post PCR-verified infection, there was a wide variation in sensitivity between the commercial IgG-assays, ranging from <30% in the N-assay to >90% in the RBD-assay. There was only moderate agreement between NAbs and CD4+ T-cell reactivity to S1 or SMN. Pre-existing CD4+ T-cell reactivity was present in similar proportions among HCW who subsequently became infected and those that did not.\n\nHCWs in COVID-19 patient care in Sweden have been infected with SARS-CoV-2 at a higher rate compared to blood donors. We demonstrate substantial variation between different IgG-assays and propose that multiple serological targets should be used to verify past infection. Our data suggest that CD4+ T-cell reactivity is not a suitable measure of past infection and does not reliably indicate protection from infection in naive individuals.", "doi": "10.3389/fimmu.2021.750448", "pmid": "34795668", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Research Area: Vaccine": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null, "Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pmc", "key": "PMC8593002"}], "notes": [], "created": "2021-12-13T08:52:58.680Z", "modified": "2022-02-14T15:04:31.373Z"}, {"entity": "publication", "iuid": "d407dcf3c4104c5cac5305cf00d65c47", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d407dcf3c4104c5cac5305cf00d65c47.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d407dcf3c4104c5cac5305cf00d65c47"}}, "title": "Identification and Development of Therapeutics for COVID-19.", "authors": [{"family": "Rando", "given": "Halie M", "initials": "HM", "orcid": "0000-0001-7688-1770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b5a9f4ec1bd48579abca9895dab3ea7.json"}}, {"family": "Wellhausen", "given": "Nils", "initials": "N", "orcid": "0000-0001-8955-7582", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/934767f0228241648d70c7b00527deff.json"}}, {"family": "Ghosh", "given": "Soumita", "initials": "S", "orcid": "0000-0002-2783-2750", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5304077580743148d3d23ee7c77be93.json"}}, {"family": "Lee", "given": "Alexandra J", "initials": "AJ", "orcid": "0000-0002-0208-3730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/761782ce14b542078b3ee6c0db2bb6ce.json"}}, {"family": "Dattoli", "given": "Anna Ada", "initials": "AA", "orcid": "0000-0003-1462-831X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fc8cf6436ef47e99880470f63f5f86a.json"}}, {"family": "Hu", "given": "Fengling", "initials": "F", "orcid": "0000-0003-1081-5038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a309350c038479199dc70af0e80a8e6.json"}}, {"family": "Byrd", "given": "James Brian", "initials": "JB", "orcid": "0000-0002-0509-3520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bc319c5d0d74676875bd9ff266f5e80.json"}}, {"family": "Rafizadeh", "given": "Diane N", "initials": "DN", "orcid": "0000-0002-2838-067X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69c8d2c22f44431ea262b7266d6be0de.json"}}, {"family": "Lordan", "given": "Ronan", "initials": "R", "orcid": "0000-0001-9668-3368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0126a49dfcdf49fcb53041fbdcd91706.json"}}, {"family": "Qi", "given": "Yanjun", "initials": "Y", "orcid": "0000-0002-5796-7453", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d48badb4eff4f4f9bf3f15632f0c3a7.json"}}, {"family": "Sun", "given": "Yuchen", "initials": "Y"}, {"family": "Brueffer", "given": "Christian", "initials": "C", "orcid": "0000-0002-3826-0989", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c4f95c1889f4f098676404aec6125ca.json"}}, {"family": "Field", "given": "Jeffrey M", "initials": "JM", "orcid": "0000-0001-7161-7284", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/851e90805f1a44b2b92711899eedb386.json"}}, {"family": "Ben Guebila", "given": "Marouen", "initials": "M", "orcid": "0000-0001-5934-966X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e04fc9008f7f4307a76515f913f19adf.json"}}, {"family": "Jadavji", "given": "Nafisa M", "initials": "NM", "orcid": "0000-0002-3557-7307", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/202cad28eb7f4f67a152ecc180ad9ffb.json"}}, {"family": "Skelly", "given": "Ashwin N", "initials": "AN", "orcid": "0000-0002-1565-3376", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9818ecec2a65431faf931d73ea71bcb2.json"}}, {"family": "Ramsundar", "given": "Bharath", "initials": "B", "orcid": "0000-0001-8450-4262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/461ff07ac9794d8cb1bc205d94bb193f.json"}}, {"family": "Wang", "given": "Jinhui", "initials": "J", "orcid": "0000-0002-5796-8130", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5243fdc11744ba89697e8fdf9c2feee.json"}}, {"family": "Goel", "given": "Rishi Raj", "initials": "RR", "orcid": "0000-0003-1715-5191", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ad2f4cb84774051bb9422f314ec0f11.json"}}, {"family": "Park", "given": "YoSon", "initials": "Y", "orcid": "0000-0002-0465-4744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d3c095fe591449a8c122645bf540ed5.json"}}, {"family": "COVID-19 Review Consortium  Vikas Bansal,  John P. Barton,  Simina M. Boca,  Joel D. Boerckel,  Christian Brueffer,  James Brian Byrd,  Stephen Capone,  Shikta Das,  Anna Ada Dattoli,  John J. Dziak,  Jeffrey M. Field,  Soumita Ghosh,  Anthony Gitter,  Rishi Raj Goel,  Casey S. Greene,  Marouen Ben Guebila,  Daniel S. Himmelstein,  Fengling Hu,  Nafisa M. Jadavji,  Jeremy P. Kamil,  Sergey Knyazev,  Likhitha Kolla,  Alexandra J. Lee,  Ronan Lordan,  Tiago Lubiana,  Temitayo Lukan,  Adam L. MacLean,  David Mai,  Serghei Mangul,  David Manheim,  Lucy D\u2019Agostino McGowan,  Amruta Naik,  YoSon Park,  Dimitri Perrin,  Yanjun Qi,  Diane N. Rafizadeh,  Bharath Ramsundar,  Halie M. Rando,  Sandipan Ray,  Michael P. Robson,  Vincent Rubinetti,  Elizabeth Sell,  Lamonica Shinholster,  Ashwin N. Skelly,  Yuchen Sun,  Yusha Sun,  Gregory L. Szeto,  Ryan Velazquez,  Jinhui Wang,  Nils Wellhausen", "given": "", "initials": ""}, {"family": "Boca", "given": "Simina M", "initials": "SM", "orcid": "0000-0002-1400-3398", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3eb0ffeffea24d5cb745b5ca86648e60.json"}}, {"family": "Gitter", "given": "Anthony", "initials": "A", "orcid": "0000-0002-5324-9833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7085c8743e3442859ad6f23198c85456.json"}}, {"family": "Greene", "given": "Casey S", "initials": "CS", "orcid": "0000-0001-8713-9213", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42aaaac8b65642538f28f9cd2045ab8d.json"}}], "type": "journal article", "published": "2021-11-02", "journal": {"title": "mSystems", "issn": "2379-5077", "pages": "e0023321", "issn-l": null}, "abstract": "After emerging in China in late 2019, the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread worldwide, and as of mid-2021, it remains a significant threat globally. Only a few coronaviruses are known to infect humans, and only two cause infections similar in severity to SARS-CoV-2: Severe acute respiratory syndrome-related coronavirus, a species closely related to SARS-CoV-2 that emerged in 2002, and Middle East respiratory syndrome-related coronavirus, which emerged in 2012. Unlike the current pandemic, previous epidemics were controlled rapidly through public health measures, but the body of research investigating severe acute respiratory syndrome and Middle East respiratory syndrome has proven valuable for identifying approaches to treating and preventing novel coronavirus disease 2019 (COVID-19). Building on this research, the medical and scientific communities have responded rapidly to the COVID-19 crisis and identified many candidate therapeutics. The approaches used to identify candidates fall into four main categories: adaptation of clinical approaches to diseases with related pathologies, adaptation based on virological properties, adaptation based on host response, and data-driven identification (ID) of candidates based on physical properties or on pharmacological compendia. To date, a small number of therapeutics have already been authorized by regulatory agencies such as the Food and Drug Administration (FDA), while most remain under investigation. The scale of the COVID-19 crisis offers a rare opportunity to collect data on the effects of candidate therapeutics. This information provides insight not only into the management of coronavirus diseases but also into the relative success of different approaches to identifying candidate therapeutics against an emerging disease. IMPORTANCE The COVID-19 pandemic is a rapidly evolving crisis. With the worldwide scientific community shifting focus onto the SARS-CoV-2 virus and COVID-19, a large number of possible pharmaceutical approaches for treatment and prevention have been proposed. What was known about each of these potential interventions evolved rapidly throughout 2020 and 2021. This fast-paced area of research provides important insight into how the ongoing pandemic can be managed and also demonstrates the power of interdisciplinary collaboration to rapidly understand a virus and match its characteristics with existing or novel pharmaceuticals. As illustrated by the continued threat of viral epidemics during the current millennium, a rapid and strategic response to emerging viral threats can save lives. In this review, we explore how different modes of identifying candidate therapeutics have borne out during COVID-19.", "doi": "10.1128/mSystems.00233-21", "pmid": "34726496", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8562484"}], "notes": [], "created": "2021-11-08T09:05:54.814Z", "modified": "2021-11-08T09:05:55.435Z"}, {"entity": "publication", "iuid": "6c2429fdd2724204a56226054af6dd87", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c2429fdd2724204a56226054af6dd87.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c2429fdd2724204a56226054af6dd87"}}, "title": "Youths' and Parents' Experiences and Perceived Effects of Internet-Based Cognitive Behavioral Therapy for Anxiety Disorders in Primary Care: Mixed Methods Study.", "authors": [{"family": "Lilja", "given": "Josefine Lotten", "initials": "JL", "orcid": "0000-0003-3623-5760", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3afa9b5d0b6448a5ba4a74576c5c96ed.json"}}, {"family": "Rupcic Ljustina", "given": "Mirna", "initials": "M", "orcid": "0000-0002-7904-326X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53b6cdc53961456693332fa4df4e77b5.json"}}, {"family": "Nissling", "given": "Linnea", "initials": "L", "orcid": "0000-0001-6479-2973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/efa4203dddeb46abacba7575fd13e6a1.json"}}, {"family": "Larsson", "given": "Anna Caroline", "initials": "AC", "orcid": "0000-0001-7530-3039", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ddc347021dd42018899efe7a3790588.json"}}, {"family": "Weineland", "given": "Sandra", "initials": "S", "orcid": "0000-0003-2428-4004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87597556008d43bf8cdbf52bcc98774b.json"}}], "type": "journal article", "published": "2021-11-01", "journal": {"title": "JMIR Pediatr Parent", "issn": "2561-6722", "volume": "4", "issue": "4", "pages": "e26842", "issn-l": null}, "abstract": "Anxiety is common among youths in primary care. Face-to-face treatment has been the first choice for clinicians, but during the COVID-19 pandemic, digital psychological interventions have substantially increased. Few studies have examined young people's interest in internet treatment or the attitudes they and their parents have toward it.\n\nThis study aims to investigate adolescents' and parents' attitudes toward and experiences of internet-based cognitive behavioral anxiety treatment in primary care and its presumptive effects.\n\nThe study used mixed methods, analyzing qualitative data thematically and quantitative data with nonparametric analysis. Participants were 14 adolescents and 14 parents recruited in adolescent primary health care clinics. The adolescents and their parents filled out mental health questionnaires before and after treatment, and were interviewed during ongoing treatment.\n\nThe quantitative data indicated that the internet-delivered cognitive behavioral therapy program used in this study was successful in reducing symptoms (\u03c722=8.333; P=.02) and that adolescents' motivation is essential to the treatment outcome (r=0.58; P=.03). The qualitative results show that youths highly value their independence and freedom to organize treatment work on their own terms. The parents expressed uncertainty about their role and how to support their child in treatment. It was important for parents to respect the youths' need for autonomy while also engaging with them in the treatment work.\n\nInternet treatment in primary care is accepted by both youths and their parents, who need clarification about the difference between their role and the therapist's role. Patient motivation should be considered before treatment, and therapists need to continue to develop the virtual alliance. Finally, primary care should be clearer in informing adolescents and their parents about the possibility of internet treatment.", "doi": "10.2196/26842", "pmid": "34723830", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "v4i4e26842"}], "notes": [], "created": "2021-11-02T15:45:37.788Z", "modified": "2021-11-02T15:45:53.028Z"}, {"entity": "publication", "iuid": "e441957c608a4603accba1b7e3c65524", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e441957c608a4603accba1b7e3c65524.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e441957c608a4603accba1b7e3c65524"}}, "title": "Transient increased immunoglobulin levels in a hyper-IgM syndrome patient with COVID-19 infection.", "authors": [{"family": "Safarirad", "given": "Molood", "initials": "M"}, {"family": "Ganji", "given": "Ali Abbaszadeh", "initials": "AA"}, {"family": "Nazari", "given": "Farzad", "initials": "F"}, {"family": "Yazdani", "given": "Reza", "initials": "R"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Motlagh", "given": "Ahmad Vosughi", "initials": "AV"}], "type": "case reports", "published": "2021-11-01", "journal": {"title": "Allergol Immunopathol (Madr)", "issn": "1578-1267", "volume": "49", "issue": "6", "pages": "63-66", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people around the world. This zoonotic-enveloped virus is primarily transmitted through inhalation. Infected people are commonly asymptomatic or manifest mild symptoms, including fever, cough, diarrhea, and fatigue. However, it may lead to severe patterns associated with multiple organ failure in individuals with an impaired immune system.\n\nHere we report a 7-year-old girl with hyper-immunoglobulin M (IgM) (HIgM) phenotype, admitted to the hospital emergency department with fever, cough, and pneumonia symptoms because of the COVID-19 infection. Coronavirus infection was confirmed by a positive real-time polymerase chain reaction test. Surprisingly, serum levels of both IgG and IgA of the patient were transiently normalized during the COVID-19 infection when tested prior to the monthly injection of intravenous immunoglobulin. After she recovered from the COVID infection, her immunoglobulin levels returned to the primary stage and she demonstrated HIgM phenotype.\n\nSince this transient increase in the levels of immunoglobulins was solely observed during the COVID-19 infection, and no other infectious episodes were diagnosed in the patient, clarifying the exact cause would help to understand in a better manner the implications and specification of humoral immunity in patients with primary antibody deficiencies.", "doi": "10.15586/aei.v49i6.92", "pmid": "34761659", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T15:17:15.274Z", "modified": "2021-11-26T15:17:15.308Z"}, {"entity": "publication", "iuid": "6a88d04a68fa4a1b84cde55ec30756bc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a88d04a68fa4a1b84cde55ec30756bc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a88d04a68fa4a1b84cde55ec30756bc"}}, "title": "The Role of Perceived Organizational Support in Mental Health of Healthcare Workers During the COVID-19 Pandemic: A Cross-Sectional Study.", "authors": [{"family": "Chatzittofis", "given": "Andreas", "initials": "A"}, {"family": "Constantinidou", "given": "Anastasia", "initials": "A"}, {"family": "Artemiadis", "given": "Artemios", "initials": "A"}, {"family": "Michailidou", "given": "Kyriaki", "initials": "K"}, {"family": "Karanikola", "given": "Maria N K", "initials": "MNK"}], "type": "journal article", "published": "2021-11-01", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "707293", "issn-l": "1664-0640"}, "abstract": "Background: Data support the link between the coronavirus disease 2019 (COVID-19) pandemic and mental distress in healthcare workers (HCWs). Although previous studies have documented the association between organizational policies and employees' psychological and mental status, there is still scant evidence regarding the effect of perceived organizational support (POS) on mental distress in HCWs during the pandemic. Aims: The present study aimed to assess the association between POS and mental distress in HCWs during the COVID-19 pandemic. The role of POS in stress, depressive and trauma symptoms in HCWs was investigated. Methods: This was an online cross-sectional study in 424 HCWs. Data were collected during the first wave of the pandemic, and included demographics, a 7-item questionnaire assessing POS, the \"Patient Health Questionnaire\" assessing depressive symptoms, the \"Impact of Events Scale Revised,\" measuring post-traumatic stress disorder (PTSD) symptoms and the \"Perceived Stress Scale\" assessing perceived stress. Results: The mean POS score was 3.33 [standard deviation:1.85; range 0-7]. Younger (p < 0.001), less experienced (p < 0.001), female (p = 0.002), and non-physician HCWs (p = 0.031) were more likely to report lower self-perceived organizational support than older, male, more experienced physicians. Self-perceived organizational support was significantly and negatively associated with and self-assessed intensity of stress, depressive and traumatic symptoms, after adjusting for putative confounders (p < 0.001). Discussion: Self-perceived organizational support was significantly associated with HCWs' self-assessed mental status during the pandemic. Organizational support and mental distress should be addressed simultaneously in HCWs during the COVID-19 pandemic to increase resilience among them.", "doi": "10.3389/fpsyt.2021.707293", "pmid": "34790134", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8591071"}], "notes": [], "created": "2021-11-26T14:10:56.848Z", "modified": "2021-11-26T14:10:56.860Z"}, {"entity": "publication", "iuid": "d5e8b547d4e5441691d8aed2a6a281ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5e8b547d4e5441691d8aed2a6a281ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5e8b547d4e5441691d8aed2a6a281ae"}}, "title": "COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study.", "authors": [{"family": "Chatzikonstantinou", "given": "Thomas", "initials": "T", "orcid": "0000-0003-4105-1253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/23021761f08c4fefa1086c5c865f5b10.json"}}, {"family": "Kapetanakis", "given": "Anargyros", "initials": "A"}, {"family": "Scarf\u00f2", "given": "Lydia", "initials": "L"}, {"family": "Karakatsoulis", "given": "Georgios", "initials": "G"}, {"family": "Allsup", "given": "David", "initials": "D", "orcid": "0000-0001-6159-6109", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2a3916e351f436e8408a950d209d2e7.json"}}, {"family": "Cabrero", "given": "Alejandro Alonso", "initials": "AA"}, {"family": "Andres", "given": "Martin", "initials": "M", "orcid": "0000-0001-9891-2988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa6138aa170b4ff3a8dd2f86a6470f25.json"}}, {"family": "Antic", "given": "Darko", "initials": "D"}, {"family": "Baile", "given": "M\u00f3nica", "initials": "M"}, {"family": "Baliakas", "given": "Panagiotis", "initials": "P"}, {"family": "Bron", "given": "Dominique", "initials": "D"}, {"family": "Capasso", "given": "Antonella", "initials": "A"}, {"family": "Chatzileontiadou", "given": "Sofia", "initials": "S"}, {"family": "Cordoba", "given": "Raul", "initials": "R"}, {"family": "Correa", "given": "Juan-Gonzalo", "initials": "JG"}, {"family": "Cu\u00e9llar-Garc\u00eda", "given": "Carolina", "initials": "C"}, {"family": "De Paoli", "given": "Lorenzo", "initials": "L"}, {"family": "De Paolis", "given": "Maria Rosaria", "initials": "MR"}, {"family": "Del Poeta", "given": "Giovanni", "initials": "G"}, {"family": "Demosthenous", "given": "Christos", "initials": "C"}, {"family": "Dimou", "given": "Maria", "initials": "M", "orcid": "0000-0001-8197-9895", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7193d5fe6b549c4a2b9786e7572d63f.json"}}, {"family": "Donaldson", "given": "David", "initials": "D"}, {"family": "Doubek", "given": "Michael", "initials": "M", "orcid": "0000-0002-1269-6282", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5407e6865c7045f1bc6e595eb7047eaa.json"}}, {"family": "Efstathopoulou", "given": "Maria", "initials": "M"}, {"family": "Eichhorst", "given": "Barbara", "initials": "B"}, {"family": "El-Ashwah", "given": "Shaimaa", "initials": "S"}, {"family": "Enrico", "given": "Alicia", "initials": "A", "orcid": "0000-0002-1983-6145", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/074670e0454c43a3b9435c0312fc6a35.json"}}, {"family": "Espinet", "given": "Blanca", "initials": "B", "orcid": "0000-0002-4294-8145", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0f362ec00c9449c95b6e68c76c8db2c.json"}}, {"family": "Farina", "given": "Lucia", "initials": "L"}, {"family": "Ferrari", "given": "Angela", "initials": "A"}, {"family": "Foglietta", "given": "Myriam", "initials": "M"}, {"family": "Frederiksen", "given": "Henrik", "initials": "H", "orcid": "0000-0001-8905-0220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0dd8e0ff7ffe4154a4bf63e0e2d2ebe5.json"}}, {"family": "F\u00fcrstenau", "given": "Moritz", "initials": "M", "orcid": "0000-0002-6593-0140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e940c65de1ea4811982480c9e043e3ed.json"}}, {"family": "Garc\u00eda-Marco", "given": "Jos\u00e9 A", "initials": "JA", "orcid": "0000-0002-8993-5982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae24000421684dd4b672a42c0175db23.json"}}, {"family": "Garc\u00eda-Serra", "given": "Roc\u00edo", "initials": "R", "orcid": "0000-0003-4857-1016", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64be4a6881bd4ee2bb3cdfe4f98aed63.json"}}, {"family": "Gentile", "given": "Massimo", "initials": "M"}, {"family": "Gimeno", "given": "Eva", "initials": "E"}, {"family": "Glenth\u00f8j", "given": "Andreas", "initials": "A"}, {"family": "Gomes da Silva", "given": "Maria", "initials": "M"}, {"family": "Gutwein", "given": "Odit", "initials": "O"}, {"family": "Hakobyan", "given": "Yervand K", "initials": "YK", "orcid": "0000-0002-9074-7831", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b93ae93cedf140bd818d21a7787a5b18.json"}}, {"family": "Herishanu", "given": "Yair", "initials": "Y"}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jos\u00e9 \u00c1ngel", "initials": "J\u00c1", "orcid": "0000-0003-4550-757X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d071af0c0a14dc695bcda29033b49ce.json"}}, {"family": "Herold", "given": "Tobias", "initials": "T", "orcid": "0000-0002-9615-9432", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce3888ebd0dc407983804c9f7cf2a1d5.json"}}, {"family": "Innocenti", "given": "Idanna", "initials": "I"}, {"family": "Itchaki", "given": "Gilad", "initials": "G"}, {"family": "Jaksic", "given": "Ozren", "initials": "O"}, {"family": "Janssens", "given": "Ann", "initials": "A"}, {"family": "Kalashnikova", "given": "\u041elga B", "initials": "\u041eB", "orcid": "0000-0002-1856-1055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c829e1da08b14c72ad0aa0eafd5b485d.json"}}, {"family": "Kalici\u0144ska", "given": "El\u017cbieta", "initials": "E"}, {"family": "Karlsson", "given": "Linda Katharina", "initials": "LK", "orcid": "0000-0003-3317-7550", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7755dec3898c4e33a5729825a8d2dacd.json"}}, {"family": "Kater", "given": "Arnon P", "initials": "AP"}, {"family": "Kersting", "given": "Sabina", "initials": "S"}, {"family": "Labrador", "given": "Jorge", "initials": "J", "orcid": "0000-0002-3696-0287", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9eab3a75d0294b74a6f9aa9eeb0b32f4.json"}}, {"family": "Lad", "given": "Deepesh", "initials": "D", "orcid": "0000-0003-3754-7774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7beb53ecbdd449e8bee3890151070af0.json"}}, {"family": "Laurenti", "given": "Luca", "initials": "L"}, {"family": "Levin", "given": "Mark-David", "initials": "MD", "orcid": "0000-0003-2139-3547", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf8f1dcff71143b7932a884334bc1eff.json"}}, {"family": "Lista", "given": "Enrico", "initials": "E"}, {"family": "Lopez-Garcia", "given": "Alberto", "initials": "A", "orcid": "0000-0002-5354-5261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c785356a67e4cbb9835fe9ce04a6153.json"}}, {"family": "Malerba", "given": "Lara", "initials": "L"}, {"family": "Marasca", "given": "Roberto", "initials": "R", "orcid": "0000-0002-6431-6878", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d0c310570274da69fb28946c66020e7.json"}}, {"family": "Marchetti", "given": "Monia", "initials": "M", "orcid": "0000-0001-7615-0572", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2fd4079badec41a7a7215d9b8fc37fb4.json"}}, {"family": "Marquet", "given": "Juan", "initials": "J"}, {"family": "Mattsson", "given": "Mattias", "initials": "M"}, {"family": "Mauro", "given": "Francesca R", "initials": "FR"}, {"family": "Milosevic", "given": "Ivana", "initials": "I"}, {"family": "Mir\u00e1s", "given": "Fatima", "initials": "F"}, {"family": "Morawska", "given": "Marta", "initials": "M"}, {"family": "Motta", "given": "Marina", "initials": "M"}, {"family": "Munir", "given": "Talha", "initials": "T"}, {"family": "Murru", "given": "Roberta", "initials": "R"}, {"family": "Niemann", "given": "Carsten U", "initials": "CU", "orcid": "0000-0001-9880-5242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b594ef0644e54a568dbe3de6847c4369.json"}}, {"family": "Rodrigues", "given": "Raquel Nunes", "initials": "RN"}, {"family": "Olivieri", "given": "Jacopo", "initials": "J"}, {"family": "Orsucci", "given": "Lorella", "initials": "L"}, {"family": "Papaioannou", "given": "Maria", "initials": "M"}, {"family": "Pavlovsky", "given": "Miguel Arturo", "initials": "MA"}, {"family": "Piskunova", "given": "Inga", "initials": "I"}, {"family": "Popov", "given": "Viola Maria", "initials": "VM", "orcid": "0000-0002-1200-379X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d0058f0e37c4164adfdc4cff9f162cc.json"}}, {"family": "Quaglia", "given": "Francesca Maria", "initials": "FM", "orcid": "0000-0003-4347-3775", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81838e15a03441b88702c3449ef0c4d1.json"}}, {"family": "Quaresmini", "given": "Giulia", "initials": "G", "orcid": "0000-0002-0993-9693", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fb23db20963401a96c3ac6e030259ae.json"}}, {"family": "Qvist", "given": "Kristian", "initials": "K"}, {"family": "Reda", "given": "Gianluigi", "initials": "G", "orcid": "0000-0003-4687-7089", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ecd84c2c9bf44fd8c7635c1420621a4.json"}}, {"family": "Rigolin", "given": "Gian Matteo", "initials": "GM", "orcid": "0000-0002-8370-5190", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e7020e591b04b72ac7ee221f8b262ba.json"}}, {"family": "Ruchlemer", "given": "Rosa", "initials": "R"}, {"family": "Saghumyan", "given": "Gevorg", "initials": "G"}, {"family": "Shrestha", "given": "Amit", "initials": "A"}, {"family": "\u0160imkovi\u010d", "given": "Martin", "initials": "M"}, {"family": "\u0160pa\u010dek", "given": "Martin", "initials": "M"}, {"family": "Sportoletti", "given": "Paolo", "initials": "P"}, {"family": "Stanca", "given": "Oana", "initials": "O"}, {"family": "Stavroyianni", "given": "Niki", "initials": "N"}, {"family": "Tadmor", "given": "Tamar", "initials": "T", "orcid": "0000-0002-3435-8612", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c968d69d0b545aaa6c99104419ac961.json"}}, {"family": "Te Raa", "given": "Doreen", "initials": "D"}, {"family": "Tonino", "given": "Sanne H", "initials": "SH"}, {"family": "Trentin", "given": "Livio", "initials": "L", "orcid": "0000-0003-1222-6149", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/affdda253d72414db28ee8e2d7682835.json"}}, {"family": "Van Der Spek", "given": "Ellen", "initials": "E"}, {"family": "van Gelder", "given": "Michel", "initials": "M"}, {"family": "van Kampen", "given": "Roel", "initials": "R"}, {"family": "Varettoni", "given": "Marzia", "initials": "M"}, {"family": "Visentin", "given": "Andrea", "initials": "A"}, {"family": "Vitale", "given": "Candida", "initials": "C", "orcid": "0000-0002-2592-8724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/654bf15e55d64f3cb3e3c43657f57c64.json"}}, {"family": "Wasik-Szczepanek", "given": "Ewa", "initials": "E"}, {"family": "Wr\u00f3bel", "given": "Tomasz", "initials": "T"}, {"family": "San Segundo", "given": "Lucrecia Y\u00e1\u00f1ez", "initials": "LY"}, {"family": "Yassin", "given": "Mohamed", "initials": "M"}, {"family": "Coscia", "given": "Marta", "initials": "M"}, {"family": "Rambaldi", "given": "Alessandro", "initials": "A"}, {"family": "Montserrat", "given": "Emili", "initials": "E"}, {"family": "Fo\u00e0", "given": "Robin", "initials": "R", "orcid": "0000-0002-5021-3026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/058a918147d247a2b0e64bca35a84ef1.json"}}, {"family": "Cuneo", "given": "Antonio", "initials": "A"}, {"family": "Stamatopoulos", "given": "Kostas", "initials": "K", "orcid": "0000-0001-8529-640X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a516e0bd6e842e5ac5c023013d6862a.json"}}, {"family": "Ghia", "given": "Paolo", "initials": "P", "orcid": "0000-0003-3750-7342", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e306a735d4d402886e386e15bfc117a.json"}}], "type": "journal article", "published": "2021-11-01", "journal": {"title": "Leukemia", "issn": "1476-5551", "issn-l": null}, "abstract": "Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41-0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02-1.04; HR = 1.79, 95% CI:1.04-3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.", "doi": "10.1038/s41375-021-01450-8", "pmid": "34725454", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41375-021-01450-8"}, {"db": "pmc", "key": "PMC8559135"}], "notes": [], "created": "2021-11-08T09:05:36.612Z", "modified": "2021-11-08T09:05:37.508Z"}, {"entity": "publication", "iuid": "b08deb7e4eb84c94955fbab22705a606", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b08deb7e4eb84c94955fbab22705a606.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b08deb7e4eb84c94955fbab22705a606"}}, "title": "Antibody response to COVID-19 mRNA vaccine (Comirnaty) in myeloma patients treated with high-dose melphalan and/or immunotherapy.", "authors": [{"family": "Lockmer", "given": "Sandra", "initials": "S"}, {"family": "Uttervall", "given": "Katarina", "initials": "K"}, {"family": "Kashif", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-7545-8548", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5441406f8f5343afa5e2cf8862fafc34.json"}}, {"family": "Sv\u00e4rd", "given": "Carina", "initials": "C"}, {"family": "Malmsten", "given": "Katarina", "initials": "K"}, {"family": "Fletcher-Torres", "given": "Evellyn", "initials": "E"}, {"family": "Alici", "given": "Evren", "initials": "E"}, {"family": "Lund", "given": "Johan", "initials": "J"}, {"family": "Nahi", "given": "Hareth", "initials": "H"}], "type": "letter", "published": "2021-11-01", "journal": {"title": "Am J Hematol", "issn": "0361-8609", "issn-l": null, "volume": "96", "issue": "11", "pages": "E443-E446"}, "abstract": null, "doi": "10.1002/ajh.26348", "pmid": "34524709", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-09-20T06:20:49.999Z", "modified": "2021-11-29T06:14:03.414Z"}, {"entity": "publication", "iuid": "ee59d1bd5bd64046968130fc3e8c53d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee59d1bd5bd64046968130fc3e8c53d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee59d1bd5bd64046968130fc3e8c53d4"}}, "title": "A trans-national examination of the impact of the COVID-19 pandemic on abortion requests through a telemedicine service", "authors": [{"family": "van Ooijen", "given": "Li\u00ebn Trudi", "initials": "LT"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}, {"family": "Gomperts", "given": "Rebecca", "initials": "R"}, {"family": "Waltz", "given": "Mitzi", "initials": "M", "orcid": "0000-0002-9089-2545", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/afe1d32b56984165980321020e20b071.json"}}], "type": "journal-article", "published": "2021-11-01", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-1991", "pages": "bmjsrh-2021-201159", "issn-l": null}, "abstract": null, "doi": "10.1136/bmjsrh-2021-201159", "pmid": null, "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-11-02T15:46:57.720Z", "modified": "2021-11-02T15:46:57.782Z"}, {"entity": "publication", "iuid": "f77db87c3a68476492f41c818af91eb0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f77db87c3a68476492f41c818af91eb0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f77db87c3a68476492f41c818af91eb0"}}, "title": "Virological and immunological features of SARS-COV-2 infected children with distinct symptomatology.", "authors": [{"family": "Cotugno", "given": "Nicola", "initials": "N"}, {"family": "Ruggiero", "given": "Alessandra", "initials": "A"}, {"family": "Pascucci", "given": "Giuseppe Rubens", "initials": "GR"}, {"family": "Bonfante", "given": "Francesco", "initials": "F"}, {"family": "Petrara", "given": "Maria Raffaella", "initials": "MR"}, {"family": "Pighi", "given": "Chiara", "initials": "C"}, {"family": "Cifaldi", "given": "Loredana", "initials": "L"}, {"family": "Zangari", "given": "Paola", "initials": "P"}, {"family": "Bernardi", "given": "Stefania", "initials": "S"}, {"family": "Cursi", "given": "Laura", "initials": "L"}, {"family": "Santilli", "given": "Veronica", "initials": "V"}, {"family": "Manno", "given": "Emma Concetta", "initials": "EC"}, {"family": "Amodio", "given": "Donato", "initials": "D"}, {"family": "Linardos", "given": "Giulia", "initials": "G"}, {"family": "Piccioni", "given": "Livia", "initials": "L"}, {"family": "Barbieri", "given": "Maria Antonietta", "initials": "MA"}, {"family": "Perrotta", "given": "Daniela", "initials": "D"}, {"family": "Campana", "given": "Andrea", "initials": "A"}, {"family": "Don\u00e0", "given": "Daniele", "initials": "D"}, {"family": "Giaquinto", "given": "Carlo", "initials": "C"}, {"family": "CACTUS Study Team", "given": "", "initials": ""}, {"family": "Concato", "given": "Carlo", "initials": "C"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "Rossi", "given": "Paolo", "initials": "P"}, {"family": "De Rossi", "given": "Anita", "initials": "A"}, {"family": "Palma", "given": "Paolo", "initials": "P", "orcid": "0000-0002-3066-4719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36e1a02e86a142c2b2d131154fb46f1c.json"}}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Pediatr Allergy Immunol", "issn": "1399-3038", "issn-l": null, "volume": "32", "issue": "8", "pages": "1833-1842"}, "abstract": "Although SARS-CoV-2 immunizations have started in most countries, children are not currently included in the vaccination programs; thus, it remains crucial to define their anti-SARS-CoV-2 immune response in order to minimize the risk for other epidemic waves. This study sought to provide a description of the virology ad anti-SARS-CoV-2 immunity in children with distinct symptomatology.\n\nBetween March and July 2020, we recruited 15 SARS-CoV-2 asymptomatic (AS) and 51 symptomatic (SY) children, stratified according to WHO clinical classification. We measured SARS-CoV-2 viral load using ddPCR and qPCR in longitudinally collected nasopharyngeal swab samples. To define anti-SARS-CoV-2 antibodies, we measured neutralization activity and total IgG load (DiaSorin). We also evaluated antigen-specific B and CD8+T cells, using a labeled S1+S2 protein and ICAM expression, respectively. Plasma protein profiling was performed with Olink.\n\nVirological profiling showed that AS patients had lower viral load at diagnosis (p = .004) and faster virus clearance (p = .0002) compared with SY patients. Anti-SARS-CoV-2 humoral and cellular response did not appear to be associated with the presence of symptoms. AS and SY patients showed similar titers of SARS-CoV-2 IgG, levels of neutralizing activity, and frequency of Ag-specific B and CD8+ T cells, whereas pro-inflammatory plasma protein profile was found to be associated with symptomatology.\n\nWe demonstrated the development of anti-SARS-CoV-2 humoral and cellular response with any regard to symptomatology, suggesting the ability of both SY and AS patients to contribute toward herd immunity. The virological profiling of AS patients suggested that they have lower virus load associated with faster virus clearance.", "doi": "10.1111/pai.13585", "pmid": "34174102", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8420243"}], "notes": [], "created": "2021-06-28T17:53:46.908Z", "modified": "2023-06-19T15:17:49.739Z"}, {"entity": "publication", "iuid": "2bbb4b1d4816465e817881ddb995850c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2bbb4b1d4816465e817881ddb995850c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2bbb4b1d4816465e817881ddb995850c"}}, "title": "The impact of public health interventions in the Nordic countries during the first year of SARS-CoV-2 transmission and evolution.", "authors": [{"family": "Duchene", "given": "Sebastian", "initials": "S"}, {"family": "Featherstone", "given": "Leo", "initials": "L"}, {"family": "Freiesleben de Blasio", "given": "Birgitte", "initials": "B"}, {"family": "Holmes", "given": "Edward C", "initials": "EC"}, {"family": "Bohlin", "given": "Jon", "initials": "J"}, {"family": "Pettersson", "given": "John H-O", "initials": "JH"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "44", "issn-l": null}, "abstract": "BackgroundMany countries have attempted to mitigate and control COVID-19 through non-pharmaceutical interventions, particularly with the aim of reducing population movement and contact. However, it remains unclear how the different control strategies impacted the local phylodynamics of the causative SARS-CoV-2 virus.AimWe aimed to assess the duration of chains of virus transmission within individual countries and the extent to which countries exported viruses to their geographical neighbours.MethodsWe analysed complete SARS-CoV-2 genomes to infer the relative frequencies of virus importation and exportation, as well as virus transmission dynamics, in countries of northern Europe. We examined virus evolution and phylodynamics in Denmark, Finland, Iceland, Norway and Sweden during the first year of the COVID-19 pandemic.ResultsThe Nordic countries differed markedly in the invasiveness of control strategies, which we found reflected in transmission chain dynamics. For example, Sweden, which compared with the other Nordic countries relied more on recommendation-based rather than legislation-based mitigation interventions, had transmission chains that were more numerous and tended to have more cases. This trend increased over the first 8 months of 2020. Together with Denmark, Sweden was a net exporter of SARS-CoV-2. Norway and Finland implemented legislation-based interventions; their transmission chain dynamics were in stark contrast to their neighbouring country Sweden.ConclusionSweden constituted an epidemiological and evolutionary refugium that enabled the virus to maintain active transmission and spread to other geographical locations. Our analysis reveals the utility of genomic surveillance where monitoring of active transmission chains is a key metric.", "doi": "10.2807/1560-7917.ES.2021.26.44.2001996", "pmid": "34738512", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8569925"}], "notes": [], "created": "2021-11-08T09:17:03.828Z", "modified": "2021-11-26T15:40:09.852Z"}, {"entity": "publication", "iuid": "fe9e07f2554c481b8ee7ea06b75e911f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fe9e07f2554c481b8ee7ea06b75e911f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fe9e07f2554c481b8ee7ea06b75e911f"}}, "title": "Risk of SARS-CoV-2 exposure among hospital healthcare workers in relation to patient contact and type of care.", "authors": [{"family": "Klevebro", "given": "Susanna", "initials": "S", "orcid": "0000-0002-1261-6502", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e192d615f8648c0ae28b5ccaf1d6803.json"}}, {"family": "Bahram", "given": "Fuad", "initials": "F"}, {"family": "Elfstr\u00f6m", "given": "K Miriam", "initials": "KM"}, {"family": "Hellberg", "given": "Ulrika", "initials": "U"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Merid", "given": "Simon Kebede", "initials": "SK"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Tornvall", "given": "Per", "initials": "P"}, {"family": "Wang", "given": "Gang", "initials": "G"}, {"family": "Conneryd Lundgren", "given": "Kalle", "initials": "K"}, {"family": "Ponzer", "given": "Sari", "initials": "S"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E", "orcid": "0000-0002-8248-0663", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58e96082947e4752a23f322e42754097.json"}}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": "49", "issue": "7", "pages": "707-712"}, "abstract": "We aimed to assess prevalence of IgG antibodies to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and factors associated with seropositivity in a large cohort of healthcare workers (HCWs).\n\nFrom 11 May until 11 June 2020, 3981 HCWs at a large Swedish emergency care hospital provided serum samples and questionnaire data. Presence of IgG antibodies to SARS-CoV-2 was measured as an indicator of SARS-CoV-2 exposure.\n\nThe total seroprevalence was 18% and increased during the study period. Among the seropositive HCWs, 11% had been entirely asymptomatic. Participants who worked with COVID-19 patients had higher odds for seropositivity: adjusted odds ratio 1.96 (95% confidence intervals 1.59-2.42). HCWs from three of the departments managing COVID-19 patients had significantly higher seroprevalences, whereas the prevalence among HCWs from the intensive care unit (also managing COVID-19 patients) was significantly lower.\n\nHCWs in contact with SARS-CoV-2 infected patients had a variable, but on average higher, likelihood for SARS-CoV-2 infections.", "doi": "10.1177/14034948211022434", "pmid": "34148454", "labels": {"Funder: KAW/SciLifeLab": null, "Research Area: High-throughput and high-content serology": null, "Funder: VR": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8521364"}], "notes": [], "created": "2021-01-29T17:26:04.393Z", "modified": "2023-06-19T15:25:12.116Z"}, {"entity": "publication", "iuid": "24f0afc328f44bff9346ba4f3046ff91", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24f0afc328f44bff9346ba4f3046ff91.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24f0afc328f44bff9346ba4f3046ff91"}}, "title": "Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021.", "authors": [{"family": "Benschop", "given": "Kimberley Sm", "initials": "KS"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Anton", "given": "Andres", "initials": "A"}, {"family": "Andr\u00e9s", "given": "Cristina", "initials": "C"}, {"family": "Aranzamendi", "given": "Maitane", "initials": "M"}, {"family": "Armannsd\u00f3ttir", "given": "Brynja", "initials": "B"}, {"family": "Bailly", "given": "Jean-Luc", "initials": "JL"}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Baldvinsd\u00f3ttir", "given": "Gu\u00f0r\u00fan Erna", "initials": "GE"}, {"family": "Beard", "given": "Stuart", "initials": "S"}, {"family": "Berginc", "given": "Natasa", "initials": "N"}, {"family": "B\u00f6ttcher", "given": "Sindy", "initials": "S"}, {"family": "Blomqvist", "given": "Soile", "initials": "S"}, {"family": "Bubba", "given": "Laura", "initials": "L"}, {"family": "Calvo", "given": "Cristina", "initials": "C"}, {"family": "Cabrerizo", "given": "Maria", "initials": "M"}, {"family": "Cavallero", "given": "Annalisa", "initials": "A"}, {"family": "Celma", "given": "Cristina", "initials": "C"}, {"family": "Ceriotti", "given": "Ferruccio", "initials": "F"}, {"family": "Costa", "given": "In\u00eas", "initials": "I"}, {"family": "Cottrell", "given": "Simon", "initials": "S"}, {"family": "Del Cuerpo", "given": "Margarita", "initials": "M"}, {"family": "Dean", "given": "Jonathan", "initials": "J"}, {"family": "Dembinski", "given": "Jennifer L", "initials": "JL"}, {"family": "Diedrich", "given": "Sabine", "initials": "S"}, {"family": "Diez-Domingo", "given": "Javier", "initials": "J"}, {"family": "Dorenberg", "given": "DagnyHaug", "initials": "D"}, {"family": "Duizer", "given": "Erwin", "initials": "E"}, {"family": "Dyrdak", "given": "Robert", "initials": "R"}, {"family": "Fanti", "given": "Diana", "initials": "D"}, {"family": "Farkas", "given": "Agnes", "initials": "A"}, {"family": "Feeney", "given": "Susan", "initials": "S"}, {"family": "Flipse", "given": "Jacky", "initials": "J"}, {"family": "De Gascun", "given": "Cillian", "initials": "C"}, {"family": "Galli", "given": "Cristina", "initials": "C"}, {"family": "Georgieva", "given": "Irina", "initials": "I"}, {"family": "Gifford", "given": "Laura", "initials": "L"}, {"family": "Guiomar", "given": "Raquel", "initials": "R"}, {"family": "H\u00f6nemann", "given": "Mario", "initials": "M"}, {"family": "Ikonen", "given": "Niina", "initials": "N"}, {"family": "Jeanno\u00ebl", "given": "Marion", "initials": "M"}, {"family": "Josset", "given": "Laurence", "initials": "L"}, {"family": "Keeren", "given": "Kathrin", "initials": "K"}, {"family": "L\u00f3pez-Labrador", "given": "F Xavier", "initials": "FX"}, {"family": "Maier", "given": "Melanie", "initials": "M"}, {"family": "McKenna", "given": "James", "initials": "J"}, {"family": "Meijer", "given": "Adam", "initials": "A"}, {"family": "Mengual-Chuli\u00e1", "given": "Beatriz", "initials": "B"}, {"family": "Midgley", "given": "Sofie E", "initials": "SE"}, {"family": "Mirand", "given": "Audrey", "initials": "A"}, {"family": "Montes", "given": "Milagrosa", "initials": "M"}, {"family": "Moore", "given": "Catherine", "initials": "C"}, {"family": "Morley", "given": "Ursula", "initials": "U"}, {"family": "Murk", "given": "Jean-Luc", "initials": "JL"}, {"family": "Nikolaeva-Glomb", "given": "Lubomira", "initials": "L"}, {"family": "Numanovic", "given": "Sanela", "initials": "S"}, {"family": "Oggioni", "given": "Massimo", "initials": "M"}, {"family": "Palminha", "given": "Paula", "initials": "P"}, {"family": "Pariani", "given": "Elena", "initials": "E"}, {"family": "Pellegrinelli", "given": "Laura", "initials": "L"}, {"family": "Piralla", "given": "Antonio", "initials": "A"}, {"family": "Pietsch", "given": "Corinna", "initials": "C"}, {"family": "Pi\u00f1eiro", "given": "Luis", "initials": "L"}, {"family": "Rabella", "given": "N\u00faria", "initials": "N"}, {"family": "Rainetova", "given": "Petra", "initials": "P"}, {"family": "Uceda Renteria", "given": "Sara Colonia", "initials": "SC"}, {"family": "Romero", "given": "Mar\u00eda P", "initials": "MP"}, {"family": "Reynders", "given": "Marijke", "initials": "M"}, {"family": "Roorda", "given": "Lieuwe", "initials": "L"}, {"family": "Savolainen-Kopra", "given": "Carita", "initials": "C"}, {"family": "Schuffenecker", "given": "Isabelle", "initials": "I"}, {"family": "Soynova", "given": "Aysa", "initials": "A"}, {"family": "Swanink", "given": "Caroline Ma", "initials": "CM"}, {"family": "Ursic", "given": "Tina", "initials": "T"}, {"family": "Verweij", "given": "Jaco J", "initials": "JJ"}, {"family": "Vila", "given": "Jorgina", "initials": "J"}, {"family": "Vuorinen", "given": "Tytti", "initials": "T"}, {"family": "Simmonds", "given": "Peter", "initials": "P"}, {"family": "Fischer", "given": "Thea K", "initials": "TK"}, {"family": "Harvala", "given": "Heli", "initials": "H"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "45", "issn-l": null}, "abstract": "We report a rapid increase in enterovirus D68 (EV-D68) infections, with 139 cases reported from eight European countries between 31 July and 14 October 2021. This upsurge is in line with the seasonality of EV-D68 and was presumably stimulated by the widespread reopening after COVID-19 lockdown. Most cases were identified in September, but more are to be expected in the coming months. Reinforcement of clinical awareness, diagnostic capacities and surveillance of EV-D68 is urgently needed in Europe.", "doi": "10.2807/1560-7917.ES.2021.26.45.2100998", "pmid": "34763750", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8646978"}], "notes": [], "created": "2021-11-26T15:15:11.761Z", "modified": "2023-06-19T14:43:53.882Z"}, {"entity": "publication", "iuid": "e686547fbd854c61b8cef013d5938d3b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e686547fbd854c61b8cef013d5938d3b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e686547fbd854c61b8cef013d5938d3b"}}, "title": "Predictors of severe COVID-19 in a registry-based Swedish cohort of patients with COPD", "authors": [{"family": "Stridsman", "given": "Caroline", "initials": "C", "orcid": "0000-0001-6622-3838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e2fc66fb68748eba5a7f8eb93c5ff3f.json"}}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW", "orcid": "0000-0002-4387-4096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bb5d1f761ef48c4837ed4f984717f0e.json"}}, {"family": "Konradsen", "given": "Jon R", "initials": "JR", "orcid": "0000-0001-7745-8624", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12c585ede9a64cb593a6dc5dbd5f02ed.json"}}, {"family": "Axelsson Fisk", "given": "Sten", "initials": "S"}, {"family": "Pedroletti", "given": "Christophe", "initials": "C"}, {"family": "Sj\u00f6\u00f6", "given": "Yvonne", "initials": "Y"}, {"family": "Syk", "given": "J\u00f6rgen", "initials": "J"}, {"family": "Sterner", "given": "Therese", "initials": "T"}, {"family": "Lindberg", "given": "Anne", "initials": "A", "orcid": "0000-0002-3292-7471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc3222a49f994e7cb8812c32e24c3a73.json"}}, {"family": "Tuns\u00e4ter", "given": "Alf", "initials": "A"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ekberg-Jansson", "given": "Ann", "initials": "A"}, {"family": "Karlsson Sundbaum", "given": "Johanna", "initials": "J"}], "type": "journal-article", "published": "2021-11-00", "journal": {"title": "Eur Respir J", "issn": "0903-1936", "issn-l": null, "volume": "58", "issue": "5", "pages": "2101920"}, "abstract": null, "doi": "10.1183/13993003.01920-2021", "pmid": "34413151", "labels": {"Type: Journal article": null, "Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [], "notes": [], "created": "2021-08-20T12:36:17.060Z", "modified": "2021-12-06T14:30:39.904Z"}, {"entity": "publication", "iuid": "3acc45d672b949c2bdc96cff5a2f37e9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3acc45d672b949c2bdc96cff5a2f37e9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3acc45d672b949c2bdc96cff5a2f37e9"}}, "title": "Plasma endostatin correlates with hypoxia and mortality in COVID-19-associated acute respiratory failure.", "authors": [{"family": "Asif", "given": "Sana", "initials": "S", "orcid": "0000-0001-7924-0936", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/336d0f6c0519467b848a7c05790665d8.json"}}, {"family": "Ruge", "given": "Thoralph", "initials": "T", "orcid": "0000-0002-1170-5183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d6fd0aae4374003924cfcc1acd004a9.json"}}, {"family": "Larsson", "given": "Anders", "initials": "A", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2be858ab604743b72383dfdcd14689.json"}}, {"family": "Anderberg", "given": "Sara B\u00fclow", "initials": "SB"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Fritiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}], "type": "clinical trial", "published": "2021-11-00", "journal": {"title": "Biomark Med", "issn": "1752-0371", "volume": "15", "issue": "16", "pages": "1509-1517", "issn-l": null}, "abstract": "Background: The contribution of endothelial injury in the pathogenesis of COVID-19-associated acute respiratory distress syndrome (ARDS) and resulting respiratory failure remains unclear. Plasma endostatin, an endogenous inhibitor of angiogenesis and endothelial dysfunction is upregulated during hypoxia, inflammation and progress of pulmonary disease. Aim: To investigate if plasma endostatin is associated to hypoxia, inflammation and 30-day mortality in patients with severe COVID-19 infection. Method: Samples for blood analysis and plasma endostatin quantification were collected from adult patients with ongoing COVID-19 (n = 109) on admission to intensive care unit (day 1). Demographic characteristics and 30-day mortality data were extracted from medical records. The ability of endostatin to predict mortality was analyzed using receiving operating characteristics and Kaplan-Meier analysis with a cutoff at 46.2 ng/ml was used to analyze the association to survival. Results: Plasma endostatin levels correlated with; PaO2/FiO2 (r = -0.3, p < 0.001), arterial oxygen tension (r = -0.2, p = 0.01), lactate (r = 0.2, p = 0.04), C-reactive protein (r = 0.2, p = 0.04), ferritin (r = 0.2, p = 0.09), D-dimer (r = 0.2, p = 0.08) and IL-6 (r = 0.4, p < 0.001). Nonsurvivors at 30 days had higher plasma endostatin levels than survivors (72 \u00b1 26 vs 56 \u00b1 16 ng/ml, p = 0.01). Receiving operating characteristic curve (area under the curve 0.7) showed that plasma endostatin >46.2 ng/ml predicts mortality with a sensitivity of 92% and specificity of 71%. In patients with plasma endostatin >46.2 ng/ml probability of survival was lower (p = 0.02) in comparison to those with endostatin <46.2 ng/ml. Conclusion: Our results suggest that plasma endostatin is an early biomarker for disease severity in COVID-19.", "doi": "10.2217/bmm-2021-0111", "pmid": "34668393", "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC8547279"}], "notes": [], "created": "2021-10-21T04:38:51.737Z", "modified": "2021-12-12T18:10:59.396Z"}, {"entity": "publication", "iuid": "fdfafb1234274fd1ad40058ec2ffc6d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fdfafb1234274fd1ad40058ec2ffc6d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fdfafb1234274fd1ad40058ec2ffc6d0"}}, "title": "Meta-analysis of the clinical performance of commercial SARS-CoV-2 nucleic acid and antibody tests up to 22 August 2020.", "authors": [{"family": "Van Walle", "given": "Ivo", "initials": "I"}, {"family": "Leitmeyer", "given": "Katrin", "initials": "K"}, {"family": "Broberg", "given": "Eeva K", "initials": "EK"}, {"family": "European COVID-19 microbiological laboratories group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "45", "issn-l": null}, "abstract": "BackgroundReliable testing for SARS-CoV-2 is key for the management of the COVID-19 pandemic.AimWe estimate diagnostic accuracy for nucleic acid and antibody tests 5 months into the COVID-19 pandemic, and compare with manufacturer-reported accuracy.MethodsWe reviewed the clinical performance of SARS-CoV-2 nucleic acid and antibody tests based on 93,757 test results from 151 published studies and 20,205 new test results from 12 countries in the European Union and European Economic Area (EU/EEA).ResultsPooling the results and considering only results with 95% confidence interval width \u2264 5%, we found four nucleic acid tests, including one point-of-care test and three antibody tests, with a clinical sensitivity \u2265 95% for at least one target population (hospitalised, mild or asymptomatic, or unknown). Nine nucleic acid tests and 25 antibody tests, 12 of them point-of-care tests, had a clinical specificity of \u2265 98%. Three antibody tests achieved both thresholds. Evidence for nucleic acid point-of-care tests remains scarce at present, and sensitivity varied substantially. Study heterogeneity was low for eight of 14 sensitivity and 68 of 84 specificity results with confidence interval width \u2264 5%, and lower for nucleic acid tests than antibody tests. Manufacturer-reported clinical performance was significantly higher than independently assessed in 11 of 32 and four of 34 cases, respectively, for sensitivity and specificity, indicating a need for improvement in this area.ConclusionContinuous monitoring of clinical performance within more clearly defined target populations is needed.", "doi": "10.2807/1560-7917.ES.2021.26.45.2001675", "pmid": "34763752", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T15:14:55.635Z", "modified": "2021-11-26T15:14:55.648Z"}, {"entity": "publication", "iuid": "16b928a1028b4122b7001d154096d8d3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16b928a1028b4122b7001d154096d8d3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16b928a1028b4122b7001d154096d8d3"}}, "title": "Mental health and well-being during COVID-19 lockdown: A survey case report of high-level male and female players of an Italian Serie A football club.", "authors": [{"family": "Ivarsson", "given": "Andreas", "initials": "A", "orcid": "0000-0002-8987-5975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e77e48568e184548a5da063cb6b339be.json"}}, {"family": "McCall", "given": "Alan", "initials": "A", "orcid": "0000-0003-3780-8153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/128f2983992a4f9b95332e3a130c9aaa.json"}}, {"family": "Mutch", "given": "Stephen", "initials": "S"}, {"family": "Giuliani", "given": "Alessia", "initials": "A"}, {"family": "Bassetto", "given": "Rita", "initials": "R"}, {"family": "Fanchini", "given": "Maurizio", "initials": "M"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Sci Med Footb", "issn": "2473-4446", "volume": "5", "issue": "sup1", "pages": "70-75", "issn-l": null}, "abstract": "To describe high-level footballers' levels and changes in mental health and well-being throughout a 8-week period of lockdown and restricted training during the COVID-19 pandemic.\n\nOne-hundred and one players belonging to four teams (women's and men's, first and U19 teams) of the same Italian Serie A club participated in the study. Data were collected through an online questionnaire, and administered at 2, 3, 5, 7 and 9 weeks after the start of the lockdown . Well-being, positive and negative affects measurements were examined.\n\nAcross the five measures, 36% of players reported clinical levels in depressive symptoms (scores \u226450) on at least one occasion. Thirteen percent of the players reported clinical levels on > 50% of the occasions. There was a decrease in depressive symptoms and negative affects over the period. No change was found in positive affects.\n\nHigh number of players reportedclinical levels of depressive symptoms compared to what was found previously in high-level athletes. The number decrease during the 8-week period. A similar trend was found for negative affects.Despite a higher prevalence in depressive symptoms earlier during lockdown, this improved as players progressed towards fewer restrictions.", "doi": "10.1080/24733938.2021.1962540", "pmid": "35077318", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2022-01-26T08:23:20.767Z", "modified": "2022-01-26T08:23:20.850Z"}, {"entity": "publication", "iuid": "b0c2ec5ca4eb4f45a757c95cf83e92ad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b0c2ec5ca4eb4f45a757c95cf83e92ad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b0c2ec5ca4eb4f45a757c95cf83e92ad"}}, "title": "Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia: The COVID STEROID randomised, placebo-controlled trial.", "authors": [{"family": "Munch", "given": "Marie Warrer", "initials": "MW", "orcid": "0000-0003-1127-9599", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd56f64f991042da935f6f3836e087b0.json"}}, {"family": "Meyhoff", "given": "Tine Sylvest", "initials": "TS", "orcid": "0000-0002-1840-1596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/766fe5fd044944faabf6a96e8d6a72f0.json"}}, {"family": "Helleberg", "given": "Marie", "initials": "M"}, {"family": "Kjaer", "given": "Maj-Brit N\u00f8rregaard", "initials": "MN", "orcid": "0000-0002-6536-0504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df8fa07399b448a5b689089e505dab58.json"}}, {"family": "Granholm", "given": "Anders", "initials": "A"}, {"family": "Hjorts\u00f8", "given": "Carl Johan Steensen", "initials": "CJS", "orcid": "0000-0003-0413-9715", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/669b4f267a51406e9f074db4ba66629f.json"}}, {"family": "Jensen", "given": "Thomas Steen", "initials": "TS"}, {"family": "M\u00f8ller", "given": "Morten Hylander", "initials": "MH", "orcid": "0000-0002-6378-9673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1cf88aaa5c9436a8e70ddfe39cfe4e8.json"}}, {"family": "Hjortrup", "given": "Peter Buhl", "initials": "PB"}, {"family": "Wetterslev", "given": "Mik", "initials": "M", "orcid": "0000-0002-8798-1133", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9848ee20a294a7da581dec0d23383c7.json"}}, {"family": "Vesterlund", "given": "Gitte Kingo", "initials": "GK", "orcid": "0000-0001-5221-3938", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6eb5ff4bc5054887bfac267b8c8af411.json"}}, {"family": "Russell", "given": "Lene", "initials": "L"}, {"family": "J\u00f8rgensen", "given": "Vibeke Lind", "initials": "VL"}, {"family": "Kristiansen", "given": "Klaus Tjelle", "initials": "KT"}, {"family": "Benfield", "given": "Thomas", "initials": "T"}, {"family": "Ulrik", "given": "Charlotte Suppli", "initials": "CS"}, {"family": "Andreasen", "given": "Anne Sofie", "initials": "AS"}, {"family": "Bestle", "given": "Morten Heiberg", "initials": "MH"}, {"family": "Poulsen", "given": "Lone Musaeus", "initials": "LM"}, {"family": "Hildebrandt", "given": "Thomas", "initials": "T"}, {"family": "Knudsen", "given": "Lene Surland", "initials": "LS"}, {"family": "M\u00f8ller", "given": "Anders", "initials": "A"}, {"family": "S\u00f8lling", "given": "Christoffer Grant", "initials": "CG"}, {"family": "Br\u00f8chner", "given": "Anne Craveiro", "initials": "AC"}, {"family": "Rasmussen", "given": "Bodil Steen", "initials": "BS", "orcid": "0000-0003-2190-145X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa66146077394afea60f71d4be6daf06.json"}}, {"family": "Nielsen", "given": "Henrik", "initials": "H"}, {"family": "Christensen", "given": "Steffen", "initials": "S"}, {"family": "Str\u00f8m", "given": "Thomas", "initials": "T"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Wahlin", "given": "Rebecka Rubenson", "initials": "RR"}, {"family": "Jakob", "given": "Stephan M", "initials": "SM"}, {"family": "Cioccari", "given": "Luca", "initials": "L"}, {"family": "Venkatesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Hammond", "given": "Naomi", "initials": "N"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Myatra", "given": "Sheila Nainan", "initials": "SN"}, {"family": "Jensen", "given": "Marie Qvist", "initials": "MQ"}, {"family": "Leistner", "given": "Jens Wolfgang", "initials": "JW"}, {"family": "Mikkelsen", "given": "Vibe Sommer", "initials": "VS", "orcid": "0000-0001-9518-0566", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e265103e395f42dba402abee098091bd.json"}}, {"family": "Svenningsen", "given": "Jens S", "initials": "JS"}, {"family": "Laursen", "given": "Signe Bj\u00f8rn", "initials": "SB"}, {"family": "Hatley", "given": "Emma Victoria", "initials": "EV"}, {"family": "Kristensen", "given": "Camilla Meno", "initials": "CM"}, {"family": "Al-Alak", "given": "Ali", "initials": "A"}, {"family": "Clapp", "given": "Esben", "initials": "E"}, {"family": "Jonassen", "given": "Trine Bak", "initials": "TB"}, {"family": "Bjerregaard", "given": "Caroline L\u00f8kke", "initials": "CL"}, {"family": "\u00d8sterby", "given": "Niels Christian Haubjerg", "initials": "NCH"}, {"family": "Jespersen", "given": "Mette Mindedahl", "initials": "MM"}, {"family": "Abou-Kassem", "given": "Dalia", "initials": "D"}, {"family": "Lassen", "given": "Mathilde Languille", "initials": "ML"}, {"family": "Zaabalawi", "given": "Reem", "initials": "R"}, {"family": "Daoud", "given": "Mohammed Mahmoud", "initials": "MM"}, {"family": "Abdi", "given": "Suhayb", "initials": "S"}, {"family": "Meier", "given": "Nick", "initials": "N"}, {"family": "la Cour", "given": "Kirstine", "initials": "K"}, {"family": "Derby", "given": "Cecilie Bauer", "initials": "CB"}, {"family": "Damlund", "given": "Birka Ravnholt", "initials": "BR"}, {"family": "Laigaard", "given": "Jens", "initials": "J"}, {"family": "Andersen", "given": "Lene Lund", "initials": "LL"}, {"family": "Mikkelsen", "given": "Johan", "initials": "J"}, {"family": "Jensen", "given": "Jeppe Lundholm Stadarfeld", "initials": "JLS", "orcid": "0000-0001-9247-8623", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/072014c0fcb84d5992707959e11dad7f.json"}}, {"family": "Rasmussen", "given": "Anders H\u00f8rby", "initials": "AH"}, {"family": "Arnerl\u00f6v", "given": "Emil", "initials": "E"}, {"family": "Lykke", "given": "Mathilde", "initials": "M"}, {"family": "Holst-Hansen", "given": "Mikkel Zacharias Bystrup", "initials": "MZB"}, {"family": "T\u00f8stesen", "given": "Boris Wied", "initials": "BW"}, {"family": "Schwab", "given": "Janne", "initials": "J"}, {"family": "Madsen", "given": "Emilie Kabel", "initials": "EK"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Lange", "given": "Theis", "initials": "T"}, {"family": "Perner", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": "65", "issue": "10", "pages": "1421-1430"}, "abstract": "In the early phase of the pandemic, some guidelines recommended the use of corticosteroids for critically ill patients with COVID-19, whereas others recommended against the use despite lack of firm evidence of either benefit or harm. In the COVID STEROID trial, we aimed to assess the effects of low-dose hydrocortisone on patient-centred outcomes in adults with COVID-19 and severe hypoxia.\n\nIn this multicentre, parallel-group, placebo-controlled, blinded, centrally randomised, stratified clinical trial, we randomly assigned adults with confirmed COVID-19 and severe hypoxia (use of mechanical ventilation or supplementary oxygen with a flow of at least 10 L/min) to either hydrocortisone (200 mg/d) vs a matching placebo for 7 days or until hospital discharge. The primary outcome was the number of days alive without life support at day 28 after randomisation.\n\nThe trial was terminated early when 30 out of 1000 participants had been enrolled because of external evidence indicating benefit from corticosteroids in severe COVID-19. At day 28, the median number of days alive without life support in the hydrocortisone vs placebo group were 7 vs 10 (adjusted mean difference: -1.1 days, 95% CI -9.5 to 7.3, P = .79); mortality was 6/16 vs 2/14; and the number of serious adverse reactions 1/16 vs 0/14.\n\nIn this trial of adults with COVID-19 and severe hypoxia, we were unable to provide precise estimates of the benefits and harms of hydrocortisone as compared with placebo as only 3% of the planned sample size were enrolled.\n\nClinicalTrials.gov: NCT04348305. European Union Drug Regulation Authorities Clinical Trials (EudraCT) Database: 2020-001395-15.", "doi": "10.1111/aas.13941", "pmid": "34138478", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8441888"}, {"db": "ClinicalTrials.gov", "key": "NCT04348305", "description": "European Union Drug Regulation Authorities Clinical Trials (EudraCT) Database: 2020-001395-15"}], "notes": [], "created": "2021-06-28T18:40:57.689Z", "modified": "2021-11-18T16:16:11.068Z"}, {"entity": "publication", "iuid": "dda5b431d9a64e4b8ed2ae8c5297c020", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dda5b431d9a64e4b8ed2ae8c5297c020.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dda5b431d9a64e4b8ed2ae8c5297c020"}}, "title": "Labor market effects of COVID-19 in Sweden and its neighbors: Evidence from administrative data.", "authors": [{"family": "Juranek", "given": "Steffen", "initials": "S"}, {"family": "Paetzold", "given": "J\u00f6rg", "initials": "J"}, {"family": "Winner", "given": "Hannes", "initials": "H"}, {"family": "Zoutman", "given": "Floris", "initials": "F"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Kyklos (Oxford)", "issn": "0023-5962", "issn-l": null, "volume": "74", "issue": "4", "pages": "512-526"}, "abstract": "This paper studies the labor market effects of non-pharmaceutical interventions (NPIs) to combat the COVID-19 pandemic. We focus on the Nordic countries which showed one of the highest variations in NPIs despite having similar community spread of COVID-19 at the onset of the pandemic: While Denmark, Finland and Norway imposed strict measures ('lockdowns'), Sweden decided for much lighter restrictions. Empirically, we use novel administrative data on weekly new unemployment and furlough spells from all 56 regions of the Nordic countries to compare the labor market outcomes of Sweden with the ones of its neighbors. Our evidence suggests that the labor markets of all countries were severely hit by the pandemic, although Sweden performed slightly better than its neighbors. Specifically, we find the worsening of the Swedish labor market to occur around 2 to 3 weeks later than in the other Nordic countries, and that its cumulative sum of new unemployment and furlough spells remained significantly lower (about 20-25%) during the time period of our study (up to week 21 of 2020).", "doi": "10.1111/kykl.12282", "pmid": "34908590", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "KYKL12282"}, {"db": "pmc", "key": "PMC8661996"}], "notes": [], "created": "2021-12-18T17:51:49.333Z", "modified": "2022-02-17T12:30:17.871Z"}, {"entity": "publication", "iuid": "0bd2b077da9d4a3091509a0596a30967", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0bd2b077da9d4a3091509a0596a30967.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0bd2b077da9d4a3091509a0596a30967"}}, "title": "How did micro-mobility change in response to COVID-19 pandemic? A case study based on spatial-temporal-semantic analytics", "authors": [{"family": "Li", "given": "Aoyong", "initials": "A", "orcid": "0000-0001-8032-5881", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a4e9267faa04311aafbfebc430a6852.json"}}, {"family": "Zhao", "given": "Pengxiang", "initials": "P"}, {"family": "Haitao", "given": "He", "initials": "H", "orcid": "0000-0002-6371-1358", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fcca1873da74684bda05ab77e5ee9a2.json"}}, {"family": "Mansourian", "given": "Ali", "initials": "A"}, {"family": "Axhausen", "given": "Kay W", "initials": "KW"}], "type": "journal-article", "published": "2021-11-00", "journal": {"title": "Computers, Environment and Urban Systems", "issn": "0198-9715", "volume": "90", "pages": "101703", "issn-l": null}, "abstract": null, "doi": "10.1016/j.compenvurbsys.2021.101703", "pmid": null, "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:52:03.764Z", "modified": "2021-10-11T17:52:03.891Z"}, {"entity": "publication", "iuid": "e050dfe1bcaa4bc998955d2a21416596", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e050dfe1bcaa4bc998955d2a21416596.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e050dfe1bcaa4bc998955d2a21416596"}}, "title": "Health and financial costs of adverse childhood experiences in 28 European countries: a systematic review and meta-analysis.", "authors": [{"family": "Hughes", "given": "Karen", "initials": "K"}, {"family": "Ford", "given": "Kat", "initials": "K"}, {"family": "Bellis", "given": "Mark A", "initials": "MA"}, {"family": "Glendinning", "given": "Freya", "initials": "F"}, {"family": "Harrison", "given": "Emma", "initials": "E"}, {"family": "Passmore", "given": "Jonathon", "initials": "J"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Lancet Public Health", "issn": "2468-2667", "volume": "6", "issue": "11", "pages": "e848-e857", "issn-l": null}, "abstract": "Adverse childhood experiences (ACEs) are associated with increased health risks across the life course. We aimed to estimate the annual health and financial burden of ACEs for 28 European countries.\n\nIn this systematic review and meta-analysis, we searched MEDLINE, CINAHL, PsycINFO, Applied Social Sciences Index and Abstracts, Criminal Justice Databases, and Education Resources Information Center for quantitative studies (published Jan 1, 1990, to Sept 8, 2020) that reported prevalence of ACEs and risks of health outcomes associated with ACEs. Pooled relative risks were calculated for associations between ACEs and harmful alcohol use, smoking, illicit drug use, high body-mass index, depression, anxiety, interpersonal violence, cancer, type 2 diabetes, cardiovascular disease, stroke, and respiratory disease. Country-level ACE prevalence was calculated using available data. Country-level population attributable fractions (PAFs) due to ACEs were generated and applied to 2019 estimates of disability-adjusted life-years. Financial costs (US$ in 2019) were estimated using an adapted human capital approach.\n\nIn most countries, interpersonal violence had the largest PAFs due to ACEs (range 14\u00b77-53\u00b75%), followed by harmful alcohol use (15\u00b77-45\u00b70%), illicit drug use (15\u00b72-44\u00b79%), and anxiety (13\u00b79%-44\u00b78%). Harmful alcohol use, smoking, and cancer had the highest ACE-attributable costs in many countries. Total ACE-attributable costs ranged from $0\u00b71 billion (Montenegro) to $129\u00b74 billion (Germany) and were equivalent to between 1\u00b71% (Sweden and Turkey) and 6\u00b70% (Ukraine) of nations' gross domestic products.\n\nAvailability of ACE data varies widely between countries and country-level estimates cannot be directly compared. However, findings suggest ACEs are associated with major health and financial costs across European countries. The cost of not investing to prevent ACEs must be recognised, particularly as countries look to recover from the COVID-19 pandemic, which interrupted services and education, and potentially increased risk factors for ACEs.\n\nWHO Regional Office for Europe.", "doi": "10.1016/S2468-2667(21)00232-2", "pmid": "34756168", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2468-2667(21)00232-2"}, {"db": "pmc", "key": "PMC8573710"}], "notes": [], "created": "2021-11-26T15:23:07.766Z", "modified": "2021-11-26T15:23:07.780Z"}, {"entity": "publication", "iuid": "a6de81647b9d48ff81db31a531c34ff8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6de81647b9d48ff81db31a531c34ff8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6de81647b9d48ff81db31a531c34ff8"}}, "title": "Evolutionary analysis of the Delta and Delta Plus variants of the SARS-CoV-2 viruses.", "authors": [{"family": "Kannan", "given": "Saathvik R", "initials": "SR"}, {"family": "Spratt", "given": "Austin N", "initials": "AN"}, {"family": "Cohen", "given": "Alisha R", "initials": "AR"}, {"family": "Naqvi", "given": "S Hasan", "initials": "SH"}, {"family": "Chand", "given": "Hitendra S", "initials": "HS"}, {"family": "Quinn", "given": "Thomas P", "initials": "TP"}, {"family": "Lorson", "given": "Christian L", "initials": "CL"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}, {"family": "Singh", "given": "Kamal", "initials": "K"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "J Autoimmun", "issn": "1095-9157", "volume": "124", "pages": "102715", "issn-l": null}, "abstract": "Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been rapidly evolving in the form of new variants. At least eleven known variants have been reported. The objective of this study was to delineate the differences in the mutational profile of Delta and Delta Plus variants. High-quality sequences (n = 1756) of Delta (B.1.617.2) and Delta Plus (AY.1 or B.1.617.2.1) variants were used to determine the prevalence of mutations (\u226520 %) in the entire SARS-CoV-2 genome, their co-existence, and change in prevalence over a period of time. Structural analysis was conducted to get insights into the impact of mutations on antibody binding. A Sankey diagram was generated using phylogenetic analysis coupled with sequence-acquisition dates to infer the migration of the Delta Plus variant and its presence in the United States. The Delta Plus variant had a significant number of high-prevalence mutations (\u226520 %) than in the Delta variant. Signature mutations in Spike (G142D, A222V, and T95I) existed at a more significant percentage in the Delta Plus variant than the Delta variant. Three mutations in Spike (K417N, V70F, and W258L) were exclusively present in the Delta Plus variant. A new mutation was identified in ORF1a (A1146T), which was only present in the Delta Plus variant with ~58 % prevalence. Furthermore, five key mutations (T95I, A222V, G142D, R158G, and K417N) were significantly more prevalent in the Delta Plus than in the Delta variant. Structural analyses revealed that mutations alter the sidechain conformation to weaken the interactions with antibodies. Delta Plus, which first emerged in India, reached the United States through England and Japan, followed by its spread to more than 20 the United States. Based on the results presented here, it is clear that the Delta and Delta Plus variants have unique mutation profiles, and the Delta Plus variant is not just a simple addition of K417N to the Delta variant. Highly correlated mutations may have emerged to keep the structural integrity of the virus.", "doi": "10.1016/j.jaut.2021.102715", "pmid": "34399188", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8354793"}, {"db": "pii", "key": "S0896-8411(21)00123-2"}], "notes": [], "created": "2021-08-17T06:35:35.248Z", "modified": "2023-01-13T14:45:01.860Z"}, {"entity": "publication", "iuid": "45243b8fa33a46138df138172a5df835", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/45243b8fa33a46138df138172a5df835.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/45243b8fa33a46138df138172a5df835"}}, "title": "Estimated number of deaths directly averted in people 60 years and older as a result of COVID-19 vaccination in the WHO European Region, December 2020 to November 2021.", "authors": [{"family": "Mesl\u00e9", "given": "Margaux Mi", "initials": "MM"}, {"family": "Brown", "given": "Jeremy", "initials": "J"}, {"family": "Mook", "given": "Piers", "initials": "P"}, {"family": "Hagan", "given": "Jos\u00e9", "initials": "J"}, {"family": "Pastore", "given": "Roberta", "initials": "R"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Spiteri", "given": "Gianfranco", "initials": "G"}, {"family": "Ravasi", "given": "Giovanni", "initials": "G"}, {"family": "Nicolay", "given": "Nathalie", "initials": "N"}, {"family": "Andrews", "given": "Nick", "initials": "N"}, {"family": "Dykhanovska", "given": "Tetiana", "initials": "T"}, {"family": "Mossong", "given": "Jo\u00ebl", "initials": "J"}, {"family": "Sadkowska-Todys", "given": "Ma\u0142gorzata", "initials": "M"}, {"family": "Nikiforova", "given": "Raina", "initials": "R"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}, {"family": "Mazagatos", "given": "Clara", "initials": "C"}, {"family": "Kyncl", "given": "Jan", "initials": "J"}, {"family": "McMenamin", "given": "Jim", "initials": "J"}, {"family": "Melillo", "given": "Tanya", "initials": "T"}, {"family": "Kaoustou", "given": "Stella", "initials": "S"}, {"family": "L\u00e9vy-Bruhl", "given": "Daniel", "initials": "D"}, {"family": "Haarhuis", "given": "Freek", "initials": "F"}, {"family": "Rich", "given": "Rivka", "initials": "R"}, {"family": "Kall", "given": "Meaghan", "initials": "M"}, {"family": "Nitzan", "given": "Dorit", "initials": "D"}, {"family": "Smallwood", "given": "Catherine", "initials": "C"}, {"family": "Pebody", "given": "Richard G", "initials": "RG"}], "type": "journal article", "published": "2021-11-00", "journal": {"issn": "1560-7917", "volume": "26", "issue": "47", "title": "Euro Surveill", "issn-l": null}, "abstract": "Since December 2019, over 1.5 million SARS-CoV-2-related fatalities have been recorded in the World Health Organization European Region - 90.2% in people \u2265 60 years. We calculated lives saved in this age group by COVID-19 vaccination in 33 countries from December 2020 to November 2021, using weekly reported deaths and vaccination coverage. We estimated that vaccination averted 469,186 deaths (51% of 911,302 expected deaths; sensitivity range: 129,851-733,744; 23-62%). Impact by country ranged 6-93%, largest when implementation was early.", "doi": "10.2807/1560-7917.ES.2021.26.47.2101021", "pmid": "34823641", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8619871"}], "notes": [], "created": "2021-11-26T13:03:12.068Z", "modified": "2021-12-18T18:20:10.012Z"}, {"entity": "publication", "iuid": "729c6621d33d4b269c6ce37008c4ae81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/729c6621d33d4b269c6ce37008c4ae81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/729c6621d33d4b269c6ce37008c4ae81"}}, "title": "Epidemiological comparison of the first and second waves of the COVID-19 pandemic in Nigeria, February 2020-April 2021.", "authors": [{"family": "Akande", "given": "Oluwatosin Wuraola", "initials": "OW", "orcid": "0000-0001-6906-895X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7ce51eb7a0b4a04b6af2802c88e2290.json"}}, {"family": "Elimian", "given": "Kelly Osezele", "initials": "KO", "orcid": "0000-0003-2729-1613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/695dddf720414c3585d35b30184f0178.json"}}, {"family": "Igumbor", "given": "Ehimario", "initials": "E", "orcid": "0000-0002-6313-6031", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff090388bcf945529573cefac01ec72d.json"}}, {"family": "Dunkwu", "given": "Lauryn", "initials": "L"}, {"family": "Kaduru", "given": "Chijioke", "initials": "C"}, {"family": "Olopha", "given": "Olubunmi Omowunmi", "initials": "OO"}, {"family": "Ohanu", "given": "Dabri Olohije", "initials": "DO"}, {"family": "Nwozor", "given": "Lilian", "initials": "L"}, {"family": "Agogo", "given": "Emmanuel", "initials": "E"}, {"family": "Aruna", "given": "Olusola", "initials": "O"}, {"family": "Balogun", "given": "Muhammad Shakir", "initials": "MS"}, {"family": "Aderinola", "given": "Olaolu", "initials": "O"}, {"family": "Ahumibe", "given": "Anthony", "initials": "A"}, {"family": "Arinze", "given": "Chinedu", "initials": "C"}, {"family": "Badaru", "given": "Sikiru Olanrewaju", "initials": "SO"}, {"family": "Nwachukwu", "given": "William", "initials": "W"}, {"family": "Dada", "given": "Augustine Olajide", "initials": "AO"}, {"family": "Erameh", "given": "Cyril", "initials": "C"}, {"family": "Hamza", "given": "Khadeejah", "initials": "K"}, {"family": "Mohammed", "given": "Tarik Benjamin", "initials": "TB"}, {"family": "Ndodo", "given": "Nnaemeka", "initials": "N"}, {"family": "Obiekea", "given": "Celestina", "initials": "C"}, {"family": "Ofoegbunam", "given": "Chinenye", "initials": "C"}, {"family": "Ogunbode", "given": "Oladipo", "initials": "O"}, {"family": "Ohonsi", "given": "Cornelius", "initials": "C"}, {"family": "Tobin", "given": "Ekaete Alice", "initials": "EA", "orcid": "0000-0001-5059-807X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b9b83f10c75414db97e06c515b1ef8d.json"}}, {"family": "Yashe", "given": "Rimamdeyati", "initials": "R"}, {"family": "Adekaiyaoja", "given": "Afolabi", "initials": "A"}, {"family": "Asuzu", "given": "Michael C", "initials": "MC"}, {"family": "Audu", "given": "Rosemary Ajuma", "initials": "RA"}, {"family": "Bello", "given": "Muhammad Bashir", "initials": "MB"}, {"family": "Bello", "given": "Shaibu Oricha", "initials": "SO"}, {"family": "Deeni", "given": "Yusuf Yahaya", "initials": "YY"}, {"family": "Disu", "given": "Yahya", "initials": "Y"}, {"family": "Joseph", "given": "Gbenga", "initials": "G"}, {"family": "Ezeokafor", "given": "Chidiebere", "initials": "C"}, {"family": "Habib", "given": "Zaiyad Garba", "initials": "ZG"}, {"family": "Ibeh", "given": "Christian", "initials": "C"}, {"family": "Ike", "given": "Ifeanyi Franklin", "initials": "IF"}, {"family": "Iwara", "given": "Emem", "initials": "E"}, {"family": "Luka-Lawal", "given": "Rejoice Kudirat", "initials": "RK"}, {"family": "Namara", "given": "Geoffrey", "initials": "G"}, {"family": "Okwor", "given": "Tochi", "initials": "T"}, {"family": "Olajide", "given": "Lois", "initials": "L"}, {"family": "Ilesanmi", "given": "Oluwafunke Olufemi", "initials": "OO"}, {"family": "Omonigho", "given": "Solomon", "initials": "S"}, {"family": "Oyiri", "given": "Ferdinand", "initials": "F"}, {"family": "Takpa", "given": "Koubagnine", "initials": "K"}, {"family": "Ugbogulu", "given": "Nkem Usha", "initials": "NU"}, {"family": "Ibekwe", "given": "Priscilla", "initials": "P"}, {"family": "Oladejo", "given": "John", "initials": "J"}, {"family": "Ilori", "given": "Elsie", "initials": "E"}, {"family": "Ochu", "given": "Chinwe Lucia", "initials": "CL", "orcid": "0000-0002-0630-7332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f390fa99a654ff899f5e9df6fbaf88e.json"}}, {"family": "Ihekweazu", "given": "Chikwe", "initials": "C"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "11", "issn-l": "2059-7908"}, "abstract": "With reports of surges in COVID-19 case numbers across over 50 countries, country-level epidemiological analysis is required to inform context-appropriate response strategies for containment and mitigation of the outbreak. We aimed to compare the epidemiological features of the first and second waves of COVID-19 in Nigeria.\n\nWe conducted a retrospective analysis of the Surveillance Outbreak Response Management and Analysis System data of the first and second epidemiological waves, which were between 27 February and 24 October 2020, and 25 October 2020 to 3 April 2021, respectively. Descriptive statistical measures including frequencies and percentages, test positivity rate (TPR), cumulative incidence (CI) and case fatality rates (CFRs) were compared. A p value of <0.05 was considered statistically significant. All statistical analyses were carried out in STATA V.13.\n\nThere were 802 143 tests recorded during the study period (362 550 and 439 593 in the first and second waves, respectively). Of these, 66 121 (18.2%) and 91 644 (20.8%) tested positive in the first and second waves, respectively. There was a 21.3% increase in the number of tests conducted in the second wave with TPR increasing by 14.3%. CI during the first and second waves were 30.3/100 000 and 42.0/100 000 respectively. During the second wave, confirmed COVID-19 cases increased among females and people 30 years old or younger and decreased among urban residents and individuals with travel history within 14 days of sample collection (p value <0.001). Most confirmed cases were asymptomatic at diagnosis during both waves: 74.9% in the first wave; 79.7% in the second wave. CFR decreased during the second wave (0.7%) compared with the first wave (1.8%).\n\nNigeria experienced a larger but less severe second wave of COVID-19. Continued implementation of public health and social measures is needed to mitigate the resurgence of another wave.", "doi": "10.1136/bmjgh-2021-007076", "pmid": "34794956", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-007076"}, {"db": "pmc", "key": "PMC8602923"}], "notes": [], "created": "2021-11-26T14:09:34.010Z", "modified": "2021-11-26T14:09:34.139Z"}, {"entity": "publication", "iuid": "31f4a05cc65c4d73a38ca74b9fc9f02f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/31f4a05cc65c4d73a38ca74b9fc9f02f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/31f4a05cc65c4d73a38ca74b9fc9f02f"}}, "title": "Decrease in community antibiotic consumption during the COVID-19 pandemic, EU/EEA, 2020.", "authors": [{"family": "H\u00f6gberg", "given": "Liselotte Diaz", "initials": "LD"}, {"family": "Vlahovi\u0107-Pal\u010devski", "given": "Vera", "initials": "V"}, {"family": "Pereira", "given": "C\u00e1tia", "initials": "C"}, {"family": "Weist", "given": "Klaus", "initials": "K"}, {"family": "Monnet", "given": "Dominique L", "initials": "DL"}, {"family": "ESAC-Net study group", "given": "", "initials": ""}, {"family": "ESAC-Net study group participants", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "46", "issn-l": null}, "abstract": "We present a European Union/European Economic Area-wide overview of the changes in consumption of antibacterials for systemic use (ATC J01) in the community between 2019 and 2020 as reported to the European Surveillance of Antimicrobial Consumption Network. Overall antibiotic consumption decreased by 18.3% between 2019 and 2020, the largest annual decrease in the network's two-decade history. We observed a strong association between the level of community antibiotic consumption in 2019 and the size of the decrease between 2019 and 2020.", "doi": "10.2807/1560-7917.ES.2021.26.46.2101020", "pmid": "34794534", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-26T14:09:52.886Z", "modified": "2021-11-26T14:09:52.901Z"}, {"entity": "publication", "iuid": "a46b973999d8441ca28db616716d9418", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a46b973999d8441ca28db616716d9418.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a46b973999d8441ca28db616716d9418"}}, "title": "Beyond building back better: imagining a future for human and planetary health.", "authors": [{"family": "de Le\u00f3n", "given": "Emilia Arag\u00f3n", "initials": "EA"}, {"family": "Shriwise", "given": "Amanda", "initials": "A"}, {"family": "Tomson", "given": "G\u00d6ran", "initials": "G"}, {"family": "Morton", "given": "Stephen", "initials": "S"}, {"family": "Lemos", "given": "Diogo Sim\u00e3o", "initials": "DS"}, {"family": "Menne", "given": "Bettina", "initials": "B"}, {"family": "Dooris", "given": "Mark", "initials": "M"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Lancet Planet Health", "issn": "2542-5196", "volume": "5", "issue": "11", "pages": "e827-e839", "issn-l": null}, "abstract": "COVID-19 is disrupting and transforming the world. We argue that transformations catalysed by this pandemic should be used to improve human and planetary health and wellbeing. This paradigm shift requires decision makers and policy makers to go beyond building back better, by nesting the economic domain of sustainable development within social and environmental domains. Drawing on the engage, assess, align, accelerate, and account (E4As) approach to implementing the 2030 Agenda for Sustainable Development, we explore the implications of this kind of radical transformative change, focusing particularly on the role of the health sector. We conclude that a recovery and transition from the COVID-19 pandemic that delivers the future humanity wants and needs requires more than a technical understanding of the transformation at hand. It also requires commitment and courage from leaders and policy makers to challenge dominant constructs and to work towards a truly thriving, equitable, and sustainable future to create a world where economic development is not an end goal itself, but a means to secure the health and wellbeing of people and the planet.", "doi": "10.1016/S2542-5196(21)00262-X", "pmid": "34774123", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2542-5196(21)00262-X"}, {"db": "pmc", "key": "PMC8600369"}], "notes": [], "created": "2021-11-26T14:29:59.933Z", "modified": "2021-11-26T14:50:38.618Z"}, {"entity": "publication", "iuid": "5c9dac66360b4cf9963f4ccc473e1a37", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c9dac66360b4cf9963f4ccc473e1a37.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c9dac66360b4cf9963f4ccc473e1a37"}}, "title": "Allergen Immunotherapy management during vaccinations: An international survey.", "authors": [{"family": "Masieri", "given": "Simonetta", "initials": "S"}, {"family": "Bachert", "given": "Claus", "initials": "C"}, {"family": "Ojeda", "given": "Pedro", "initials": "P"}, {"family": "Kim", "given": "Chang-Keun", "initials": "CK"}, {"family": "Carlo", "given": "Cavaliere", "initials": "C"}, {"family": "Giorgio", "given": "Ciprandi", "initials": "C"}, {"family": "Study Group on AIT & Vaccinations", "given": "", "initials": ""}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "World Allergy Organ J", "issn": "1939-4551", "volume": "14", "issue": "11", "pages": "100601", "issn-l": "1939-4551"}, "abstract": "Vaccination against viral and bacterial pathogens represents a challenging issue in allergic subjects, mainly concerning patients undergoing allergen immunotherapy (AIT). For this reason, an international survey has been performed involving a panel of experts who responded to a series of questions, also concerning the COVID-19 impact on allergen immunotherapy and vaccinations. The results showed that co-administration of vaccines and AIT requires caution, mainly during the pandemic era. Moreover, the choice of AIT product should be oriented considering also the safety profile.", "doi": "10.1016/j.waojou.2021.100601", "pmid": "34777679", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1939-4551(21)00095-8"}, {"db": "pmc", "key": "PMC8575483"}], "notes": [], "created": "2021-11-26T14:25:04.676Z", "modified": "2021-11-26T14:25:04.693Z"}, {"entity": "publication", "iuid": "398f1033a4704b8c8d3fee900804eaba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/398f1033a4704b8c8d3fee900804eaba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/398f1033a4704b8c8d3fee900804eaba"}}, "title": "Flexibility during the COVID-19 Pandemic Response: Healthcare Facility Assessment Tools for Resilient Evaluation.", "authors": [{"family": "Brambilla", "given": "Andrea", "initials": "A", "orcid": "0000-0001-7891-0336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24f99c1c49954fd9a1806ce9641c1dce.json"}}, {"family": "Sun", "given": "Tian-Zhi", "initials": "TZ"}, {"family": "Elshazly", "given": "Waleed", "initials": "W"}, {"family": "Ghazy", "given": "Ahmed", "initials": "A"}, {"family": "Barach", "given": "Paul", "initials": "P"}, {"family": "Lindahl", "given": "G\u00f6ran", "initials": "G"}, {"family": "Capolongo", "given": "Stefano", "initials": "S"}], "type": "journal article", "published": "2021-10-31", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "21", "issn-l": null}, "abstract": "Healthcare facilities are facing huge challenges due to the outbreak of COVID-19. Around the world, national healthcare contingency plans have struggled to cope with the population health impact of COVID-19, with healthcare facilities and critical care systems buckling under the extraordinary pressures. COVID-19 has starkly highlighted the lack of reliable operational tools for assessing the level sof flexibility of a hospital building to support strategic and agile decision making. The aim of this study was to modify, improve and test an existing assessment tool for evaluating hospital facilities flexibility and resilience. We followed a five-step process for collecting data by (i) doing a literature review about flexibility principles and strategies, (ii) reviewing healthcare design guidelines, (iii) examining international healthcare facilities case studies, (iv) conducting a critical review and optimization of the existing tool, and (v) assessing the usability of the evaluation tool. The new version of the OFAT framework (Optimized Flexibility Assessment Tool) is composed of nine evaluation parameters and subdivided into measurable variables with scores ranging from 0 to 10. The pilot testing of case studies enabled the assessment and verification the OFAT validity and reliability in support of decision makers in addressing flexibility of hospital design and/or operations. Healthcare buildings need to be designed and built based on principles of flexibility to accommodate current healthcare operations, adapting to time-sensitive physical transformations and responding to contemporary and future public health emergencies.", "doi": "10.3390/ijerph182111478", "pmid": "34769993", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijerph182111478"}, {"db": "pmc", "key": "PMC8583089"}], "notes": [], "created": "2021-11-26T15:08:47.801Z", "modified": "2021-11-26T15:08:47.858Z"}, {"entity": "publication", "iuid": "9aa3eb392c194c629eb50d77a4876866", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9aa3eb392c194c629eb50d77a4876866.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9aa3eb392c194c629eb50d77a4876866"}}, "title": "Cardiovascular events and safety outcomes associated with remdesivir using a World Health Organization international pharmacovigilance database.", "authors": [{"family": "Jung", "given": "Se Yong", "initials": "SY", "orcid": "0000-0003-1337-563X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e77bcc25ff234e30b8b5b67aab7dc06f.json"}}, {"family": "Kim", "given": "Min Seo", "initials": "MS"}, {"family": "Li", "given": "Han", "initials": "H"}, {"family": "Lee", "given": "Keum Hwa", "initials": "KH", "orcid": "0000-0002-1511-9587", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f05874950d04389af6deb3a0067b914.json"}}, {"family": "Koyanagi", "given": "Ai", "initials": "A", "orcid": "0000-0002-9565-5004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ed135d1694d4ec9858491cfbcba065d.json"}}, {"family": "Solmi", "given": "Marco", "initials": "M"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A", "orcid": "0000-0002-2945-2946", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9e0f16d2f4a444c82a37156bcf3f1b4.json"}}, {"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Tizaoui", "given": "Kalthoum", "initials": "K"}, {"family": "Cargnin", "given": "Sarah", "initials": "S"}, {"family": "Terrazzino", "given": "Salvatore", "initials": "S", "orcid": "0000-0002-4909-1121", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/643fa55ffcdb43fb90bad571f8c0e121.json"}}, {"family": "Hong", "given": "Sung Hwi", "initials": "SH"}, {"family": "Abou Ghayda", "given": "Ramy", "initials": "R"}, {"family": "Kim", "given": "Nam Kyun", "initials": "NK"}, {"family": "Chung", "given": "Seo Kyoung", "initials": "SK"}, {"family": "Jacob", "given": "Louis", "initials": "L", "orcid": "0000-0003-1071-1239", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f59bc7c0941a462aa7426d8e2a995b30.json"}}, {"family": "Salem", "given": "Joe-Elie", "initials": "JE", "orcid": "0000-0002-0331-3307", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48ca28bff1864378845333f93c6926f8.json"}}, {"family": "Yon", "given": "Dong Keon", "initials": "DK", "orcid": "0000-0003-1628-9948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/747eb5856d2e444fbc1e5aaef8d3aa40.json"}}, {"family": "Lee", "given": "Seung Won", "initials": "SW", "orcid": "0000-0001-5632-5208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b38b67e00dbf4d80a72a30152b99c0a3.json"}}, {"family": "Kostev", "given": "Karel", "initials": "K"}, {"family": "Kim", "given": "Ah Young", "initials": "AY"}, {"family": "Jung", "given": "Jo Won", "initials": "JW"}, {"family": "Choi", "given": "Jae Young", "initials": "JY"}, {"family": "Shin", "given": "Jin Soo", "initials": "JS"}, {"family": "Park", "given": "Soon-Jung", "initials": "SJ"}, {"family": "Choi", "given": "Seong Woo", "initials": "SW"}, {"family": "Ban", "given": "Kiwon", "initials": "K"}, {"family": "Moon", "given": "Sung-Hwan", "initials": "SH"}, {"family": "Go", "given": "Yun Young", "initials": "YY"}, {"family": "Shin", "given": "Jae Il", "initials": "JI", "orcid": "0000-0003-2326-1820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ca450cb43e3478d81ba93be745f0ea0.json"}}, {"family": "Smith", "given": "Lee", "initials": "L"}], "type": "journal article", "published": "2021-10-31", "journal": {"title": "Clin Transl Sci", "issn": "1752-8062", "issn-l": "1752-8054"}, "abstract": "On October 2020, the US Food and Drug Administration (FDA) approved remdesivir as the first drug for the treatment of coronavirus disease 2019 (COVID-19), increasing remdesivir prescriptions worldwide. However, potential cardiovascular (CV) toxicities associated with remdesivir remain unknown. We aimed to characterize the CV adverse drug reactions (ADRs) associated with remdesivir using VigiBase, an individual case safety report database of the World Health Organization (WHO). Disproportionality analyses of CV-ADRs associated with remdesivir were performed using reported odds ratios and information components. We conducted in vitro experiments using cardiomyocytes derived from human pluripotent stem cell cardiomyocytes (hPSC-CMs) to confirm cardiotoxicity of remdesivir. To distinguish drug-induced CV-ADRs from COVID-19 effects, we restricted analyses to patients with COVID-19 and found that, after adjusting for multiple confounders, cardiac arrest (adjusted odds ratio [aOR]: 1.88, 95% confidence interval [CI]: 1.08-3.29), bradycardia (aOR: 2.09, 95% CI: 1.24-3.53), and hypotension (aOR: 1.67, 95% CI: 1.03-2.73) were associated with remdesivir. In vitro data demonstrated that remdesivir reduced the cell viability of hPSC-CMs in time- and dose-dependent manners. Physicians should be aware of potential CV consequences following remdesivir use and implement adequate CV monitoring to maintain a tolerable safety margin.", "doi": "10.1111/cts.13168", "pmid": "34719115", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:54:53.842Z", "modified": "2021-11-01T19:54:54.146Z"}, {"entity": "publication", "iuid": "f011d680507b424ca14ca9eda9d3eb7b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f011d680507b424ca14ca9eda9d3eb7b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f011d680507b424ca14ca9eda9d3eb7b"}}, "title": "Stockpiling and food worries: Changing habits and choices in the midst of COVID-19 pandemic.", "authors": [{"family": "Amuakwa-Mensah", "given": "Franklin", "initials": "F"}, {"family": "Amuakwa-Mensah", "given": "Salome", "initials": "S"}, {"family": "Klege", "given": "Rebecca Afua", "initials": "RA"}, {"family": "Adom", "given": "Philip Kofi", "initials": "PK"}], "type": "journal article", "published": "2021-10-30", "journal": {"title": "Socioecon Plann Sci", "issn": "0038-0121", "pages": "101181", "issn-l": null}, "abstract": "Albeit, governments have instituted strong containment measures in the wake of the COVID-19 pandemic, concerns of continuous local spread and economic impact of the virus are impacting global food chains and food security. This paper investigates the effect of concern about the i) local spread and ii) economic impact of COVID-19, on the change in the amount of food and necessities bought in twelve Sub-Sahara African countries. In addition, we examine if these effects are channeled through food worries. The study uses a unique survey dataset by GeoPoll collected in April 2020 (first round) and May 2020 (second round) and employs a multinomial logit and generalized structural equation models. We find significant effect of concern about COVID-19 on change in the package size of food and necessities bought, which is heterogeneous across gender group and rural-urban divide. Our results reveal that concerns of COVID-19 might be promoting stockpiling behavior among females and those with no food worries (due to having sufficient money or resources). This if not properly managed could in the medium to long-term affect the food supply chain, food waste and exacerbate food worries problem especially for already food deprived homes. We discuss the policy implications.", "doi": "10.1016/j.seps.2021.101181", "pmid": "34744190", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0038-0121(21)00173-7"}, {"db": "pmc", "key": "PMC8562977"}], "notes": [], "created": "2021-11-26T15:36:31.982Z", "modified": "2021-11-26T15:36:32.016Z"}, {"entity": "publication", "iuid": "f6aa34deb2484c9cab3553f51015f89d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6aa34deb2484c9cab3553f51015f89d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6aa34deb2484c9cab3553f51015f89d"}}, "title": "Quality of Life, Needs and Fears of Mothers of Children with Disabilities in Saudi Arabia during the COVID-19 Lockdown.", "authors": [{"family": "Al Awaji", "given": "Nisreen", "initials": "N"}, {"family": "Aldhahi", "given": "Monira", "initials": "M", "orcid": "0000-0002-5255-4860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a3b7b4eb7d6440da62df1e4d091329b.json"}}, {"family": "Akil", "given": "Shahnaz", "initials": "S", "orcid": "0000-0002-3256-4543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c031d893b12b4c4ca8cbb330a89384d0.json"}}, {"family": "Awad", "given": "Salwa", "initials": "S"}, {"family": "Mortada", "given": "Eman", "initials": "E"}], "type": "journal article", "published": "2021-10-30", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "21", "pages": null}, "abstract": "Substantial changes in life dynamics resulting from the outbreak of the coronavirus disease 2019 (COVID-19) could have an impact on the quality of life (QoL) of mothers of children with and without disabilities. This study compared the quality of life (QoL) of mothers of children with disabilities (MCD) to the QoL of mothers of children without disabilities (CON) in Saudi Arabia during COVID-19 lockdown. It explored mothers' concerns and the type of support they need during the quarantine. A comparative cross-sectional study was conducted during the lockdown. An online questionnaire was distributed to mothers raising children with and without disabilities in Saudi Arabia. A total of 340 mothers participated in the study by completing the survey: 93 MCD and 247 CON. The QoL of MCD and CON was assessed using the WHOQOL-BREF questionnaire. Furthermore, detailed information was provided by the mothers regarding their needs and concerns during the lockdown. The results of the study revealed that the overall QoL was significantly higher in the CON group, compared to the MCD group, during the COVID-19 lockdown. The social well-being and environmental well-being reported by MCD were significantly lower on the total scale of the WHOQOL-BREF than those reported by the CON group. The comparison between the two groups revealed significant differences in the support required by mothers during the COVID-19 pandemic: a higher percentage of MCD needed emotional and psychological support, especially from family members. The major concerns reported by MCD were the deterioration of their children's medical conditions and the lack of medical supplies during the lockdown.", "doi": "10.3390/ijerph182111442", "pmid": "34769958", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182111442"}, {"db": "pmc", "key": "PMC8583177"}], "notes": [], "created": "2021-11-26T15:09:15.845Z", "modified": "2022-02-17T12:28:28.363Z"}, {"entity": "publication", "iuid": "6c6a0d8aa3044e1d85c5d613e6374d85", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c6a0d8aa3044e1d85c5d613e6374d85.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c6a0d8aa3044e1d85c5d613e6374d85"}}, "title": "On the brink of disruption: Applying Resilience Engineering to anticipate system performance under crisis.", "authors": [{"family": "Arcuri", "given": "Rodrigo", "initials": "R"}, {"family": "Bellas", "given": "Hugo Cesar", "initials": "HC"}, {"family": "Ferreira", "given": "Denise de Souza", "initials": "DS"}, {"family": "Bulh\u00f5es", "given": "B\u00e1rbara", "initials": "B"}, {"family": "Vidal", "given": "Mario Cesar Rodr\u00edguez", "initials": "MCR"}, {"family": "Carvalho", "given": "Paulo Victor Rodrigues de", "initials": "PVR"}, {"family": "Jatob\u00e1", "given": "Alessandro", "initials": "A"}, {"family": "Hollnagel", "given": "Erik", "initials": "E"}], "type": "journal article", "published": "2021-10-30", "journal": {"title": "Appl Ergon", "issn": "1872-9126", "volume": "99", "pages": "103632", "issn-l": null}, "abstract": "As COVID-19 spread across Brazil, it quickly reached remote regions including Amazon's ultra-peripheral locations where patient transportation through rivers is added to the list of obstacles to overcome. This article analyses the pandemic's effects in the access of riverine communities to the prehospital emergency healthcare system in the Brazilian Upper Amazon River region. To do so, we present two studies that by using a Resilience Engineering approach aimed to predict the functioning of the Brazilian Mobile Emergency Medical Service (SAMU) for riverside and coastal areas during the COVID-19 pandemic, based on the normal system functioning. Study I, carried out before the pandemic, applied ethnographic methods for data collection and the Functional Resonance Analysis Method - FRAM for data analysis in order to develop a model of the mobile emergency care in the region during typical conditions of operation. Study II then estimated how changes in variability dynamics would alter system functioning during the pandemic, arriving at three trends that could lead the service to collapse. Finally, the accuracy of predictions is discussed after the pandemic first peaked in the region. Findings reveal that relatively small changes in variability dynamics can deliver strong implications to operating care and safety of expeditions aboard water ambulances. Also, important elements that add to the resilient capabilities of the system are extra-organizational, and thus during the pandemic safety became jeopardized as informal support networks grew fragile. Using FRAM for modelling regular operation enabled prospective scenario analysis that accurately predicted disruptions in providing emergency care to riverine population.", "doi": "10.1016/j.apergo.2021.103632", "pmid": "34740073", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0003-6870(21)00279-9"}, {"db": "pmc", "key": "PMC8557093"}], "notes": [], "created": "2021-11-08T09:20:43.862Z", "modified": "2021-11-08T09:20:43.899Z"}, {"entity": "publication", "iuid": "ac08bcfa36fc43cdab597875f30bf61d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac08bcfa36fc43cdab597875f30bf61d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac08bcfa36fc43cdab597875f30bf61d"}}, "title": "Circulating levels of calprotectin, a signature of neutrophil activation in prediction of severe respiratory failure in COVID-19 patients: a multicenter, prospective study (CalCov study).", "authors": [{"family": "Garc\u00eda de Guadiana-Romualdo", "given": "Luis", "initials": "L", "orcid": "0000-0003-3028-3198", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2733220d3ab54ff5adb9fe765ee033a8.json"}}, {"family": "Rodr\u00edguez Rojas", "given": "Carlos", "initials": "C"}, {"family": "Morell-Garc\u00eda", "given": "Daniel", "initials": "D"}, {"family": "Andaluz-Ojeda", "given": "David", "initials": "D"}, {"family": "Rodr\u00edguez Mulero", "given": "Mar\u00eda Dolores", "initials": "MD"}, {"family": "Rodr\u00edguez-Borja", "given": "Enrique", "initials": "E"}, {"family": "Ballesteros-Vizoso", "given": "Antonieta", "initials": "A"}, {"family": "Calvo", "given": "Mar\u00eda Dolores", "initials": "MD"}, {"family": "Albert-Botella", "given": "Lourdes", "initials": "L"}, {"family": "Pozo Gir\u00e1ldez", "given": "Adela", "initials": "A"}, {"family": "Llompart-Alabern", "given": "Isabel", "initials": "I"}, {"family": "Bolado Jim\u00e9nez", "given": "Cristina", "initials": "C"}, {"family": "Hern\u00e1ndez Olivo", "given": "Marta", "initials": "M"}, {"family": "Fern\u00e1ndez Presa", "given": "Luc\u00eda", "initials": "L"}, {"family": "Ortega-P\u00e9rez", "given": "Juan", "initials": "J"}, {"family": "Fora Romero", "given": "Mar\u00eda Jos\u00e9", "initials": "MJ"}, {"family": "Campos-Rodr\u00edguez", "given": "Valerio", "initials": "V"}, {"family": "Ballester F\u00e9rriz", "given": "Andrea", "initials": "A"}, {"family": "Guiu-Mart\u00ed", "given": "Alexandra M", "initials": "AM"}, {"family": "Pinilla Arribas", "given": "Leyre", "initials": "L"}, {"family": "Galindo Mart\u00ednez", "given": "Mar\u00eda", "initials": "M"}, {"family": "Puerto-Lara", "given": "Edwin R", "initials": "ER"}, {"family": "L\u00f3pez Tarazaga", "given": "Ana Belen", "initials": "AB"}, {"family": "Ros Braquehais", "given": "Mar\u00eda Salom\u00e9", "initials": "MS"}, {"family": "Nogales Mart\u00edn", "given": "Leonor", "initials": "L"}, {"family": "Juez Santamar\u00eda", "given": "Celia", "initials": "C"}, {"family": "Trapiello Fern\u00e1ndez", "given": "Wysalli", "initials": "W"}, {"family": "Espinilla Fern\u00e1ndez", "given": "Virginia", "initials": "V"}, {"family": "Havelka", "given": "Aleksandra", "initials": "A"}, {"family": "Albaladejo-Ot\u00f3n", "given": "Mar\u00eda Dolores", "initials": "MD"}], "type": "journal article", "published": "2021-10-30", "journal": {"title": "Inflamm Res", "issn": "1420-908X", "issn-l": null}, "abstract": "Severe COVID-19 is characterized by a dysregulated immune response in which neutrophils play a critical role. Calprotectin reflects neutrophil activation and is involved in the self-amplifying thrombo-inflammatory storm in severe COVID-19. We aimed to evaluate the role of calprotectin in early prediction of severity in COVID-19 patients.\n\nThis was a multicenter prospective observational study enrolling consecutive adult COVID-19 patients. On arrival to emergency department, blood samples were collected for laboratory tests, including serum calprotectin. The primary outcome was severe respiratory failure requiring invasive mechanical ventilation and the secondary outcome was need for Intensive Care Unit (ICU) admission.\n\nStudy population included 395 patients, 57 (14.4%) required invasive mechanical ventilation and 100 (25.3%) were admitted to ICU. Median serum calprotectin levels were significantly higher in intubated (3.73 mg/L vs. 2.63 mg/L; p < 0.001) and ICU patients (3.48 mg/L vs. 2.60 mg/L; p = 0.001). Calprotectin showed a significant accuracy to predict the need for invasive mechanical ventilation (ROC AUC 0.723) and ICU admission (ROC AUC 0.650). In multivariate analysis, serum calprotectin was an independent predictor of invasive mechanical ventilation (OR 1.161) and ICU admission (OR 1.068).\n\nSerum calprotectin can be used as an early predictor of severity in COVID-19 patients.", "doi": "10.1007/s00011-021-01516-4", "pmid": "34718856", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00011-021-01516-4"}], "notes": [], "created": "2021-11-01T19:54:06.861Z", "modified": "2021-11-01T19:54:21.246Z"}, {"entity": "publication", "iuid": "df253a1d3287495c9060e507e78366d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/df253a1d3287495c9060e507e78366d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/df253a1d3287495c9060e507e78366d9"}}, "title": "The mediational role of trust in the healthcare system in the association between generalized trust and willingness to get COVID-19 vaccination in Iran.", "authors": [{"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Yahaghai", "given": "Rafat", "initials": "R"}, {"family": "Alimoradi", "given": "Zainab", "initials": "Z", "orcid": "0000-0001-5327-2411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9456bb442847e688c1cbfd8dac99cb.json"}}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-10-29", "journal": {"title": "Hum Vaccin Immunother", "issn": "2164-554X", "pages": "1-8", "issn-l": null}, "abstract": "For some individuals, there appears to be some level of unwillingness in getting a COVID-19 vaccine which may be due to trust issues. The present study used a mediation model to investigate how trust is associated with an individual's willingness to get COVID-19 vaccination among Iranians. A total of 10,843 Iranian adults were recruited in Qazvin province using a multistage stratified cluster sampling method. The survey was completed between February 19 and April 9, 2021. The findings showed that generalized trust was positively associated with trust in the healthcare system, trust in the healthcare system was positively associated with willingness to get COVID-19 vaccination, and generalized trust was positively associated with willingness to get COVID-19 vaccination. Also, trust in the healthcare system mediated the association between generalized trust and willingness to get COVID-19 vaccination. There were some significant demographic differences in COVID-19 vaccination willingness. The findings suggest that generalized trust plays a significant role in directly or indirectly influencing individuals' willingness to get COVID-19 vaccine. Therefore, government bodies and health officials may utilize these findings to appeal in a more transparent and professional manner in encouraging individuals to get a COVID-19 vaccine. However, for those with lower trust levels (in general and in the healthcare system), the focus may be to re-build and/or regain the individuals' trust through carefully planned transparent communication, information dissemination, and ethical education to help increase the uptake of COVID-19 vaccination.", "doi": "10.1080/21645515.2021.1993689", "pmid": "34715009", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:52:03.368Z", "modified": "2021-11-01T19:52:19.468Z"}, {"entity": "publication", "iuid": "629a71d80887407eb7e5a456db40bb93", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/629a71d80887407eb7e5a456db40bb93.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/629a71d80887407eb7e5a456db40bb93"}}, "title": "Patient delay prior to care-seeking in acute myocardial infarction during the outbreak of the coronavirus SARS-CoV2 pandemic.", "authors": [{"family": "Lidin", "given": "Matthias", "initials": "M"}, {"family": "Lyng\u00e5", "given": "Patrik", "initials": "P"}, {"family": "Kinch-Westerdahl", "given": "Annika", "initials": "A"}, {"family": "Nymark", "given": "Carolin", "initials": "C", "orcid": "0000-0003-0891-6358", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26ae7dfc5d824e6ba7fda3c21ac670ef.json"}}], "type": "journal article", "published": "2021-10-29", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "issn-l": null}, "abstract": "To examine patient delay in seeking medical care when afflicted by an acute myocardial infarction during March-June 2020.\n\nThis was a cross-sectional study in a region in Sweden during the first wave of the COVID-19 pandemic examining patients selected from the national registry (SWEDEHEART). Eligible patients were those with acute myocardial infarction, and a total of 602 patients were invited. A self-administered psychometric evaluated questionnaire, 'Patients' appraisal, emotions, and action tendencies preceding care-seeking in acute myocardial infarction' (AMI), was sent to the patients, and questions regarding COVID-19 were added. A total of 326 patients answered the questionnaire. Of these, 19% hesitated to seek medical care because of the pandemic, which was related to a fear that the healthcare services were already overcrowded with patients with COVID-19, followed by a fear of becoming infected with COVID-19 in hospital. Characteristics of this cohort were significantly higher prevalences of women, immigrants, smokers, and patients with type 2 diabetes.\n\nDuring the outbreak and first wave of the COVID-19 pandemic, women and immigrants delayed seeking medical care for AMI because of fears about overcrowded hospitals and about becoming infected themselves. Therefore, during the COVID-19 pandemic, it is especially important to convey information about how and when to seek medical care. A collaboration involving the healthcare professionals, patient organizations, and the media would be desirable.", "doi": "10.1093/eurjcn/zvab087", "pmid": "34718511", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6414289"}], "notes": [], "created": "2021-11-01T19:53:39.156Z", "modified": "2021-11-01T19:53:39.196Z"}, {"entity": "publication", "iuid": "f7807f3a744240b5aa8bc1c5aad426d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7807f3a744240b5aa8bc1c5aad426d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7807f3a744240b5aa8bc1c5aad426d4"}}, "title": "Effect of Resilience on Health-Related Quality of Life during the COVID-19 Pandemic: A Cross-Sectional Study.", "authors": [{"family": "Aldhahi", "given": "Monira I", "initials": "MI", "orcid": "0000-0002-5255-4860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a3b7b4eb7d6440da62df1e4d091329b.json"}}, {"family": "Akil", "given": "Shahnaz", "initials": "S", "orcid": "0000-0002-3256-4543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c031d893b12b4c4ca8cbb330a89384d0.json"}}, {"family": "Zaidi", "given": "Uzma", "initials": "U"}, {"family": "Mortada", "given": "Eman", "initials": "E"}, {"family": "Awad", "given": "Salwa", "initials": "S"}, {"family": "Al Awaji", "given": "Nisreen", "initials": "N", "orcid": "0000-0002-1853-0398", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ea5b5f49bdb409fada8f8aab77ae39b.json"}}], "type": "journal article", "published": "2021-10-29", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "21", "pages": null}, "abstract": "The unprecedented outbreak of coronavirus disease 2019 (COVID-19) has caused a huge global health and economic crisis. The aim of the study was to examine the extent to which the resilience of a person is associated with the quality of life (QoL) of adults amongst Saudi Arabia. A cross-sectional study was conducted among a sample of adults in Saudi Arabia. A total of 385 adults voluntarily participated in and completed the survey. The quality of life was measured using the \"World Health Organization QoL\". The \"Connor-Davidson Resilience Scale\" instrument was also used to assess resilience during the COVID-19 pandemic. Amongst the 385 participants, 179 (46%) showed a good QoL, and 205 (54%) reported a relatively poor QoL. The resilience was found to be significantly associated with QoL. The study further revealed that gender-based differences were dominant in the QoL; the men respondents reported a significantly higher QoL in all the domains in comparison to the women respondents. The gender, income, and psychological health and interaction effect of resilience and age explained 40% of the variance in the total score of QoL. In reference to the predictors of the physical health domain of QoL, resilience, gender, and psychological health were significantly associated with the physical health domain of the QoL (R2 = 0.26, p = 0.001). It was also noted that gender was not associated with the social relationships and environmental domains of QoL (p > 0.05). Findings showed a statistically significant association between the score of QoL and resilience, age, gender, income, and psychological health. These findings highlight the significant contribution of gender-based differences, psychological health, and resilience on the domains of QoL.", "doi": "10.3390/ijerph182111394", "pmid": "34769907", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182111394"}, {"db": "pmc", "key": "PMC8582796"}], "notes": [], "created": "2021-11-26T15:09:47.678Z", "modified": "2022-02-17T12:26:29.079Z"}, {"entity": "publication", "iuid": "6b1c03b1fc744ce7bd7498966d975600", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b1c03b1fc744ce7bd7498966d975600.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b1c03b1fc744ce7bd7498966d975600"}}, "title": "Detection of SARS-CoV-2 by rapid antigen tests on saliva in hospitalized patients with COVID-19.", "authors": [{"family": "De Marinis", "given": "Yang", "initials": "Y", "orcid": "0000-0002-8081-2142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c85c6f6e14a44415a2bea1cfe224e50c.json"}}, {"family": "Pesola", "given": "Anne-Katrine", "initials": "AK"}, {"family": "S\u00f6derlund Strand", "given": "Anna", "initials": "A"}, {"family": "Norman", "given": "Astrid", "initials": "A"}, {"family": "Pernow", "given": "Gustav", "initials": "G"}, {"family": "Ald\u00e9n", "given": "Markus", "initials": "M"}, {"family": "Yang", "given": "Runtao", "initials": "R"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1588-5473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c760e8d21ae441ba236f86e6185d392.json"}}], "type": "journal article", "published": "2021-10-29", "journal": {"title": "Infect Ecol Epidemiol", "issn": "2000-8686", "volume": "11", "issue": "1", "pages": "1993535", "issn-l": "2000-8686"}, "abstract": "The COVID-19 pandemic presents great challenges on transmission prevention, and rapid diagnosis is essential to reduce the disease spread. Various diagnostic methods are available to identify an ongoing infection by nasopharyngeal (NPH) swab sampling. However, the procedure requires handling by health care professionals, and therefore limits the application in household and community settings.\n\nIn this study, we aimed to determine if the detection of SARS-CoV-2 can be performed alternatively on saliva specimens by rapid antigen test.\n\nSaliva and NPH specimens were collected from 44 patients with confirmed COVID-19. To assess the diagnostic accuracy of point-of-care SARS-CoV-2 rapid antigen test on saliva specimens, we compared the performance of four test products.\n\nRT-qPCR was performed and NPH and saliva sampling had similar Ct values, which associated with disease duration. All four antigen tests showed similar trend in detecting SARS-CoV-2 in saliva, but with variation in the ability to detect positive cases. The rapid antigen test with the best performance could detect up to 67% of the positive cases with Ct values lower than 25, and disease duration shorter than 10 days.\n\nOur study therefore supports saliva testing as an alternative diagnostic procedure to NPH testing, and that rapid antigen test on saliva provides a potential complement to PCR test to meet increasing screening demand.", "doi": "10.1080/20008686.2021.1993535", "pmid": "34745449", "labels": {"Category: Health": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "1993535"}, {"db": "pmc", "key": "PMC8567870"}], "notes": [], "created": "2021-11-10T11:40:29.186Z", "modified": "2021-11-26T15:35:05.776Z"}, {"entity": "publication", "iuid": "62ff8b720a574f95a3e5c8707da35fd6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/62ff8b720a574f95a3e5c8707da35fd6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/62ff8b720a574f95a3e5c8707da35fd6"}}, "title": "The Barriers, Challenges, and Strategies of COVID-19 (SARS-CoV-2) Vaccine Acceptance: A Concurrent Mixed-Method Study in Tehran City, Iran.", "authors": [{"family": "Khankeh", "given": "Hamid Reza", "initials": "HR"}, {"family": "Farrokhi", "given": "Mehrdad", "initials": "M"}, {"family": "Khanjani", "given": "Mohammad Saeed", "initials": "MS"}, {"family": "Momtaz", "given": "Yadollah Abolfathi", "initials": "YA", "orcid": "0000-0003-1939-1470", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d0e1d04e09d74c19b349fac72d8e6cd7.json"}}, {"family": "Forouzan", "given": "Ameneh Setareh", "initials": "AS", "orcid": "0000-0001-9668-1389", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80e56b61b3a0447ebd9865c0f1a734a7.json"}}, {"family": "Norouzi", "given": "Mehdi", "initials": "M"}, {"family": "Ahmadi", "given": "Shokoufeh", "initials": "S"}, {"family": "Harouni", "given": "Gholamreza Ghaedamini", "initials": "GG", "orcid": "0000-0003-1197-5068", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09e64a733cff438ea73ced998027307d.json"}}, {"family": "Roudini", "given": "Juliet", "initials": "J"}, {"family": "Ghanaatpisheh", "given": "Elham", "initials": "E"}, {"family": "Hamedanchi", "given": "Arya", "initials": "A", "orcid": "0000-0001-5879-5561", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69adb9f4402744879df4d532e6d609a8.json"}}, {"family": "Pourebrahimi", "given": "Mohammad", "initials": "M"}, {"family": "Alipour", "given": "Fardin", "initials": "F"}, {"family": "Ranjbar", "given": "Maryam", "initials": "M"}, {"family": "Naghikhani", "given": "Mehrdad", "initials": "M"}, {"family": "Saatchi", "given": "Mohammad", "initials": "M"}], "type": "journal article", "published": "2021-10-28", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "9", "issue": "11", "issn-l": null}, "abstract": "Acceptance and willingness to receive the vaccine are among the main factors in the success or failure of a health system in implementing the vaccination program. The present study was conducted in Tehran, the political and economic capital of Iran, to determine the acceptance of the COVID-19 vaccine and identify its associated factors, and explain the most important barriers and acceptance strategies for vaccination. This research was a concurrent quantitative and qualitative mixed-method study. In the quantitative part, 1200 individuals aged more than 18 years were selected from the households in 22 districts of Tehran City, with a multistage stratified cluster sampling method. Two questionnaires were used to evaluate the acceptance of the COVID-19 vaccine and vaccine acceptance determinants. The qualitative content analysis method addressed the influencing factors, as well as challenges and strategies related to the acceptance of the COVID-19 vaccine in four groups of Tehran inhabitants: the elderly, people with underlying diseases, healthcare workers, and the general population. The related data were simultaneously collected by applying in-depth semi-structural interviews and a data analysis process. Furthermore, we used the Graneheim and Lundman method for data analysis. We analyzed the data of 1200 people with a mean (SD) age of 46.4 (11.1) years, and approximately 58% of them were men. The vaccine acceptance was 83.6% (95% CI: 81.3-85.9). Among those who welcomed vaccination, 58% preferred the imported vaccines, 25% the Iranian ones, and 17% both. There was a significant association between the variables of age (adjusted odds ratio [AOR] = 1.72, 95% CI: 1.01-2.93), being single (AOR = 0.54, 95% CI: 0.41-0.91), moderate pharmacotherapy adherence (AOR = 0.58, 95% CI: 0.4-0.85), and the willingness to receive COVID-19 vaccine. Qualitative study after interviewing 45 people from four study groups showed an insufficient social trust in healthcare system officials, pharmaceutical and vaccine production companies; distrust in the effectiveness of the vaccines, concerns about the vaccine adverse effects, being tracked by microchips after vaccination, traditional anti-vaccination movements, the feeling the inessentiality of vaccination, and uncertainty about the fair distribution of the vaccine. These concerns were the main challenges addressed by the study groups. A good proportion of Tehran residents reported their willingness to receive the COVID-19 vaccine. Additionally, they expressed their critical concerns, such as insufficient trust in the healthcare system, vaccine safeties, and adverse effects that were the significant barriers to vaccine acceptance. It seems that conflicts raised by the shortage of vaccines and their import due to the sanctions have led to intense desire and demand in the general population, and especially the elderly, for vaccination. Besides, vaccination phobia in some individuals requires further investigations.", "doi": "10.3390/vaccines9111248", "pmid": "34835179", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "vaccines9111248"}, {"db": "pmc", "key": "PMC8620861"}], "notes": [], "created": "2021-12-18T18:14:17.824Z", "modified": "2021-12-18T18:14:30.396Z"}, {"entity": "publication", "iuid": "16b970005ba045cfb91c5d275a6062f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16b970005ba045cfb91c5d275a6062f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16b970005ba045cfb91c5d275a6062f1"}}, "title": "Rapid inactivation of SARS-CoV-2 with LED irradiation of visible spectrum wavelengths.", "authors": [{"family": "De Santis", "given": "Riccardo", "initials": "R"}, {"family": "Luca", "given": "Vincenzo", "initials": "V"}, {"family": "N\u00e4slund", "given": "Jonas", "initials": "J"}, {"family": "Ehmann", "given": "Rosina K", "initials": "RK"}, {"family": "De Angelis", "given": "Marta", "initials": "M"}, {"family": "Lundmark", "given": "Eva", "initials": "E"}, {"family": "Nencioni", "given": "Lucia", "initials": "L"}, {"family": "Faggioni", "given": "Giovanni", "initials": "G"}, {"family": "Fillo", "given": "Silvia", "initials": "S"}, {"family": "Amatore", "given": "Donatella", "initials": "D"}, {"family": "Regalbuto", "given": "Elisa", "initials": "E"}, {"family": "Molinari", "given": "Filippo", "initials": "F"}, {"family": "Petralito", "given": "Giancarlo", "initials": "G"}, {"family": "W\u00f6lfel", "given": "Roman", "initials": "R"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Rezza", "given": "Gianni", "initials": "G"}, {"family": "Palamara", "given": "Anna Teresa", "initials": "AT"}, {"family": "Antwerpen", "given": "Markus", "initials": "M"}, {"family": "Forsman", "given": "Mats", "initials": "M"}, {"family": "Lista", "given": "Florigio", "initials": "F"}], "type": "journal article", "published": "2021-10-28", "journal": {"title": "J Photochem Photobiol", "issn": "2666-4690", "pages": "100082", "issn-l": null}, "abstract": "Difficulty in controlling SARS-CoV-2 transmission made the ability to inactivate viruses in aerosols and fomites to be an important and attractive risk reduction measure. Evidence that light frequencies have the ability to inhibit microorganisms has already been reported by many studies which, however, focused on ultraviolet (UV) wavelengths, which are known to induce potential injury in humans. In the present study, the effect on suspensions of SARS-CoV-2 of a Light Emitting Diode (LED) device capable of radiating frequencies in the non-hazardous visible light spectrum (VIS) was investigated. In order to evaluate the efficiency of viral inactivation, plaque assay and western blot of viral proteins were performed. The observed results showed a significant reduction in infectious particles that had been exposed to the LED irradiation of visible light. Furthermore, the analysis of the intracellular expression of viral proteins confirmed the inactivating effect of this irradiation technology. This in vitro study revealed for the first time the inactivation of SAR-CoV-2 through LED irradiation with multiple wavelengths of the visible spectrum. However additional and more in-depth studies can aim to demonstrate the data obtained during these experiments in different matrices, in mutable environmental conditions and on other respiratory viruses such as the influenza virus, the type of LED technology can decisively contribute on reducing virus transmission through the continuous sanitation of common environments without risks for humans and animals.", "doi": "10.1016/j.jpap.2021.100082", "pmid": "34729540", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2666-4690(21)00067-1"}, {"db": "pmc", "key": "PMC8552801"}], "notes": [], "created": "2021-11-08T09:06:28.550Z", "modified": "2021-11-08T09:06:28.588Z"}, {"entity": "publication", "iuid": "66a83c2299dc46f2b4ae52efcb0ca12a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66a83c2299dc46f2b4ae52efcb0ca12a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66a83c2299dc46f2b4ae52efcb0ca12a"}}, "title": "Health, Lifestyle, and Psycho-Social Determinants of Poor Sleep Quality During the Early Phase of the COVID-19 Pandemic: A Focus on UK Older Adults Deemed Clinically Extremely Vulnerable.", "authors": [{"family": "Udeh-Momoh", "given": "Chinedu T", "initials": "CT"}, {"family": "Watermeyer", "given": "Tamlyn", "initials": "T"}, {"family": "Sindi", "given": "Shireen", "initials": "S"}, {"family": "Giannakopoulou", "given": "Parthenia", "initials": "P"}, {"family": "Robb", "given": "Catherine E", "initials": "CE"}, {"family": "Ahmadi-Abhari", "given": "Sara", "initials": "S"}, {"family": "Zheng", "given": "Bang", "initials": "B"}, {"family": "Waheed", "given": "Amina", "initials": "A"}, {"family": "McKeand", "given": "James", "initials": "J"}, {"family": "Salman", "given": "David", "initials": "D"}, {"family": "Beaney", "given": "Thomas", "initials": "T"}, {"family": "de Jager Loots", "given": "Celeste A", "initials": "CA"}, {"family": "Price", "given": "Geraint", "initials": "G"}, {"family": "Atchison", "given": "Christina", "initials": "C"}, {"family": "Car", "given": "Josip", "initials": "J"}, {"family": "Majeed", "given": "Azeem", "initials": "A"}, {"family": "McGregor", "given": "Alison H", "initials": "AH"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Ward", "given": "Helen", "initials": "H"}, {"family": "Middleton", "given": "Lefkos T", "initials": "LT"}], "type": "journal article", "published": "2021-10-28", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "753964", "issn-l": "2296-2565"}, "abstract": "Background: Several studies have assessed the impact of COVID-19-related lockdowns on sleep quality across global populations. However, no study to date has specifically assessed at-risk populations, particularly those at highest risk of complications from coronavirus infection deemed \"clinically-extremely-vulnerable-(COVID-19CEV)\" (as defined by Public Health England). Methods: In this cross-sectional study, we surveyed 5,558 adults aged \u226550 years (of whom 523 met criteria for COVID-19CEV) during the first pandemic wave that resulted in a nationwide-lockdown (April-June 2020) with assessments of sleep quality (an adapted sleep scale that captured multiple sleep indices before and during the lockdown), health/medical, lifestyle, psychosocial and socio-demographic factors. We examined associations between these variables and sleep quality; and explored interactions of COVID-19CEV status with significant predictors of poor sleep, to identify potential moderating factors. Results: Thirty-seven percent of participants reported poor sleep quality which was associated with younger age, female sex and multimorbidity. Significant associations with poor sleep included health/medical factors: COVID-19CEV status, higher BMI, arthritis, pulmonary disease, and mental health disorders; and the following lifestyle and psychosocial factors: living alone, higher alcohol consumption, an unhealthy diet and higher depressive and anxiety symptoms. Moderators of the negative relationship between COVID-19CEV status and good sleep quality were marital status, loneliness, anxiety and diet. Within this subgroup, less anxious and less lonely males, as well as females with healthier diets, reported better sleep. Conclusions: Sleep quality in older adults was compromised during the sudden unprecedented nation-wide lockdown due to distinct modifiable factors. An important contribution of our study is the assessment of a \"clinically-extremely-vulnerable\" population and the sex differences identified within this group. Male and female older adults deemed COVID-19CEV may benefit from targeted mental health and dietary interventions, respectively. This work extends the available evidence on the notable impact of lack of social interactions during the COVID-19 pandemic on sleep, and provides recommendations toward areas for future work, including research into vulnerability factors impacting sleep disruption and COVID-19-related complications. Study results may inform tailored interventions targeted at modifiable risk factors to promote optimal sleep; additionally, providing empirical data to support health policy development in this area.", "doi": "10.3389/fpubh.2021.753964", "pmid": "34869170", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8637825"}], "notes": [], "created": "2021-12-12T07:09:20.670Z", "modified": "2021-12-12T07:09:20.684Z"}, {"entity": "publication", "iuid": "3217be6cf6ad4eaeaffbf01370c6b69d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3217be6cf6ad4eaeaffbf01370c6b69d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3217be6cf6ad4eaeaffbf01370c6b69d"}}, "title": "Comparative safety of mRNA COVID-19 vaccines to influenza vaccines: A pharmacovigilance analysis using WHO international database.", "authors": [{"family": "Kim", "given": "Min Seo", "initials": "MS", "orcid": "0000-0003-2115-7835", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3078a38bd45044b3ac5b32d0eb09fbda.json"}}, {"family": "Jung", "given": "Se Yong", "initials": "SY", "orcid": "0000-0003-1337-563X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e77bcc25ff234e30b8b5b67aab7dc06f.json"}}, {"family": "Ahn", "given": "Jong Gyun", "initials": "JG"}, {"family": "Park", "given": "Se Jin", "initials": "SJ"}, {"family": "Shoenfeld", "given": "Yehuda", "initials": "Y"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Tizaoui", "given": "Kalthoum", "initials": "K", "orcid": "0000-0001-8524-6058", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/acc834b554f14509911d1a594332a808.json"}}, {"family": "Hong", "given": "Sung Hwi", "initials": "SH"}, {"family": "Jacob", "given": "Louis", "initials": "L", "orcid": "0000-0003-1071-1239", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f59bc7c0941a462aa7426d8e2a995b30.json"}}, {"family": "Salem", "given": "Joe-Elie", "initials": "JE"}, {"family": "Yon", "given": "Dong Keon", "initials": "DK", "orcid": "0000-0003-1628-9948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/747eb5856d2e444fbc1e5aaef8d3aa40.json"}}, {"family": "Lee", "given": "Seung Won", "initials": "SW", "orcid": "0000-0001-5632-5208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b38b67e00dbf4d80a72a30152b99c0a3.json"}}, {"family": "Ogino", "given": "Shuji", "initials": "S", "orcid": "0000-0002-3909-2323", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/310326a713e7419ba514ded7472e97b6.json"}}, {"family": "Kim", "given": "Hanna", "initials": "H"}, {"family": "Kim", "given": "Jerome H", "initials": "JH"}, {"family": "Excler", "given": "Jean-Louis", "initials": "JL"}, {"family": "Marks", "given": "Florian", "initials": "F"}, {"family": "Clemens", "given": "John D", "initials": "JD"}, {"family": "Eisenhut", "given": "Michael", "initials": "M"}, {"family": "Barnett", "given": "Yvonne", "initials": "Y"}, {"family": "Butler", "given": "Laurie", "initials": "L"}, {"family": "Ilie", "given": "Cristian Petre", "initials": "CP"}, {"family": "Shin", "given": "Eui-Cheol", "initials": "EC", "orcid": "0000-0002-6308-9503", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbc368fed9a340a1adcd420100422844.json"}}, {"family": "Il Shin", "given": "Jae", "initials": "J", "orcid": "0000-0003-2326-1820", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ca450cb43e3478d81ba93be745f0ea0.json"}}, {"family": "Smith", "given": "Lee", "initials": "L"}], "type": "journal article", "published": "2021-10-28", "journal": {"title": "J Med Virol", "issn": "1096-9071", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Two messenger RNA (mRNA) vaccines developed by Pfizer-BioNTech and Moderna are being rolled out. Despite the high volume of emerging evidence regarding adverse events (AEs) associated with the COVID-19 mRNA vaccines, previous studies have thus far been largely based on the comparison between vaccinated and unvaccinated control, possibly highlighting the AE risks with COVID-19 mRNA vaccination. Comparing the safety profile of mRNA vaccinated individuals with otherwise vaccinated individuals would enable a more relevant assessment for the safety of mRNA vaccination. We designed a comparative safety study between 18 755 and 27 895 individuals who reported to VigiBase for adverse events following immunization (AEFI) with mRNA COVID-19 and influenza vaccines, respectively, from January 1, 2020, to January 17, 2021. We employed disproportionality analysis to rapidly detect relevant safety signals and compared comparative risks of a diverse span of AEFIs for the vaccines. The safety profile of novel mRNA vaccines was divergent from that of influenza vaccines. The overall pattern suggested that systematic reactions like chill, myalgia, fatigue were more noticeable with the mRNA COVID-19 vaccine, while injection site reactogenicity events were more prevalent with the influenza vaccine. Compared to the influenza vaccine, mRNA COVID-19 vaccines demonstrated a significantly higher risk for a few manageable cardiovascular complications, such as hypertensive crisis (adjusted reporting odds ratio [ROR], 12.72; 95% confidence interval [CI], 2.47-65.54), and supraventricular tachycardia (adjusted ROR, 7.94; 95% CI, 2.62-24.00), but lower risk of neurological complications such as syncope, neuralgia, loss of consciousness, Guillain-Barre syndrome, gait disturbance, visual impairment, and dyskinesia. This study has not identified significant safety concerns regarding mRNA vaccination in real-world settings. The overall safety profile patterned a lower risk of serious AEFI following mRNA vaccines compared to influenza vaccines.", "doi": "10.1002/jmv.27424", "pmid": "34709664", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:48:34.182Z", "modified": "2021-11-29T06:07:21.030Z"}, {"entity": "publication", "iuid": "9ca3a6ec6e8b40ed879bd7983425ed90", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ca3a6ec6e8b40ed879bd7983425ed90.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ca3a6ec6e8b40ed879bd7983425ed90"}}, "title": "Comments on the Discussion Forum: Oromucosal immunomodulation as clinical spectrum mitigating factor in SARS-CoV-2 infection.", "authors": [{"family": "Smith", "given": "Michael L", "initials": "ML", "orcid": "0000-0003-4103-8614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4c9b76424464a188d2880c45a0f4303.json"}}, {"family": "Sharma", "given": "Sujata", "initials": "S"}, {"family": "Singh", "given": "Tej P", "initials": "TP"}], "type": "journal article", "published": "2021-10-28", "journal": {"title": "Scand J Immunol", "issn": "1365-3083", "pages": "e13111", "issn-l": null}, "abstract": "We read the excellent presentation by Rodriguez-Argente and coauthors and wish to add some thoughts to the discussion1 . The lactoperoxidase (LPO) system is actually the first line of mammalian, immunological defense against airborne bacterial and viral infections, including influenza and the respiratory syncytial virus (RSV)2,3 . This is not well known and some textbooks of immunology don't even mention this system.", "doi": "10.1111/sji.13111", "pmid": "34709678", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:49:35.555Z", "modified": "2021-11-01T19:49:35.593Z"}, {"entity": "publication", "iuid": "392bb2b4eb104c54bcf476998fd646df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/392bb2b4eb104c54bcf476998fd646df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/392bb2b4eb104c54bcf476998fd646df"}}, "title": "COVID-19 in lung transplant recipients: an overview of the Swedish national experience.", "authors": [{"family": "Magnusson", "given": "Jesper M", "initials": "JM"}, {"family": "Larsson", "given": "Hillevi", "initials": "H"}, {"family": "Alsaleh", "given": "Ahmed", "initials": "A"}, {"family": "Ekelund", "given": "Jan", "initials": "J"}, {"family": "Karason", "given": "Kristjan", "initials": "K"}, {"family": "Schult", "given": "Andreas", "initials": "A"}, {"family": "Friman", "given": "Vanda", "initials": "V"}, {"family": "Felldin", "given": "Marie", "initials": "M"}, {"family": "S\u00f8fteland", "given": "John Mackay", "initials": "JM"}, {"family": "Dellgren", "given": "G\u00f6ran", "initials": "G"}, {"family": "Oltean", "given": "Mihai", "initials": "M"}], "type": "journal article", "published": "2021-10-28", "journal": {"title": "Transpl Int", "issn": "1432-2277", "issn-l": null}, "abstract": "Although it is known that solid organ transplant recipients fare worse after COVID-19 infection, data on the impact of COVID-19 on clinical outcomes and allograft function in lung transplant (LTx) recipients are limited and based mainly on reports with short follow-up.\n\nIn this nationwide study, all LTx recipients with COVID-19 diagnosed from February 1st, 2020 to April 30th, 2021, were included. The patients were followed until August 1st 2021, or death. We analysed demographics, clinical features, therapeutic management, and outcomes, including lung function.\n\nForty-seven patients were identified: median age was 59 (10-78) years, 53.1% were male, and median follow-up was 194 (23-509) days. COVID-19 was asymptomatic or mild at presentation in 48.9%. Nine patients (19.1%) were vaccinated pre-COVID infection. Two patients (4.3%) died within 28 days of testing positive, and the overall survival rate was 85.1%. The patients with asymptomatic or mild symptoms had a higher median % expected forced expiratory volume during the first second than the patients with worse symptoms (p=0.004).\n\nLTx recipients develop the entire spectrum of COVID-19, and in addition to previously acknowledged risk factors, lower pre-COVID lung function was associated with more severe disease presentation.", "doi": "10.1111/tri.14148", "pmid": "34709680", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:50:31.415Z", "modified": "2021-11-01T19:50:31.428Z"}, {"entity": "publication", "iuid": "00b63ab548dd4754b5f8e8d7edad2fdd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/00b63ab548dd4754b5f8e8d7edad2fdd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/00b63ab548dd4754b5f8e8d7edad2fdd"}}, "title": "COVID-19 Vaccinations: Summary Guidance for Cancer Patients in 28 Languages: Breaking Barriers to Cancer Patient Information.", "authors": [{"family": "Davide", "given": "Mauri", "initials": "M"}, {"family": "Kamposioras", "given": "Konstantinos", "initials": "K"}, {"family": "Lampriani", "given": "Tsali", "initials": "T"}, {"family": "Mario", "given": "Dambrosio", "initials": "D"}, {"family": "Berardino", "given": "De Bari", "initials": "B"}, {"family": "Nadia", "given": "Hindi", "initials": "H"}, {"family": "Carl", "given": "Salembier", "initials": "S"}, {"family": "Joanna", "given": "Nixon", "initials": "N"}, {"family": "Dimitrios", "given": "Tzachanis", "initials": "T"}, {"family": "Flippo", "given": "Alongi", "initials": "A"}, {"family": "Hassan", "given": "Hameed", "initials": "H"}, {"family": "Antonios", "given": "Valachis", "initials": "V"}, {"family": "Konstantinos", "given": "Papadimitriou", "initials": "P"}, {"family": "Stefanie", "given": "Corradini", "initials": "C"}, {"family": "Lazar", "given": "Popovic", "initials": "P"}, {"family": "Jindrich", "given": "Kopecky", "initials": "K"}, {"family": "Andres", "given": "Rodriguez", "initials": "R"}, {"family": "Katarina", "given": "Antunac", "initials": "A"}, {"family": "Junlin", "given": "Yi", "initials": "Y"}, {"family": "Lovey", "given": "Jozsef", "initials": "J"}, {"family": "Primoz", "given": "Strojan", "initials": "S"}, {"family": "Haytham", "given": "Saraireh", "initials": "S"}, {"family": "Ranveig", "given": "R\u00f8tterud", "initials": "R"}, {"family": "Marzanna", "given": "Chojnacka", "initials": "C"}, {"family": "Olalla", "given": "Santa Cruz", "initials": "SC"}, {"family": "Natalia", "given": "Chilingirova", "initials": "C"}, {"family": "Ramon A", "given": "De Mello", "initials": "M"}, {"family": "Giovanna", "given": "Araujo Amaral", "initials": "AA"}, {"family": "Farsid", "given": "Arbabi", "initials": "A"}, {"family": "Radu", "given": "Vidra", "initials": "V"}, {"family": "Erjeta", "given": "Rapushi", "initials": "R"}, {"family": "D", "given": "Takeuchi", "initials": "T"}, {"family": "Chirstos", "given": "Christopoulos", "initials": "C"}, {"family": "Irina", "given": "Ivanova", "initials": "I"}, {"family": "Igor", "given": "Djan", "initials": "D"}, {"family": "Branka", "given": "Petricevic", "initials": "P"}, {"family": "Francesco", "given": "Cellini", "initials": "C"}, {"family": "Iglika", "given": "Mihaylova", "initials": "M"}, {"family": "Natalija", "given": "Dedic Plavetic", "initials": "DP"}, {"family": "Cvetka", "given": "Gra\u0161i\u010d Kuhar", "initials": "GK"}, {"family": "Elena", "given": "Takeuchi", "initials": "T"}, {"family": "Pantelis", "given": "Kountourakis", "initials": "K"}, {"family": "Panagiotis", "given": "Ntellas", "initials": "N"}, {"family": "Ioanna", "given": "Gazouli", "initials": "G"}, {"family": "Stefania", "given": "Gkoura", "initials": "G"}, {"family": "Salih", "given": "Yuce", "initials": "Y"}, {"family": "Er", "given": "\u00d6zlem", "initials": "\u00d6"}, {"family": "Yasmina", "given": "Chait", "initials": "C"}, {"family": "Kumaran", "given": "Gireesh", "initials": "G"}, {"family": "Orges", "given": "Spahiu", "initials": "S"}, {"family": "Aasim", "given": "Yusuf", "initials": "Y"}, {"family": "Gono", "given": "Paulina", "initials": "P"}, {"family": "Apostolidis", "given": "Kathi", "initials": "K"}, {"family": "Tolia", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-10-28", "journal": {"title": "Rev Recent Clin Trials", "issn": "1876-1038", "issn-l": null}, "abstract": "Covid-19 vaccination has started in the majority of the countries at the global level. Cancer patients are at high risk for infection, serious illness, and death from COVID-19 and need vaccination guidance and support. Guidance availability in the English language only is a major limit for recommendations' delivery and their application in the world's population and generates information inequalities across the different populations.\n\nMost of the available COVID-19 vaccination guidance for cancer patients was screened and scrutinized by the European Cancer Patients Coalition (ECPC) and an international oncology panel of 52 physicians from 33 countries.\n\nA summary guidance was developed and provided in 28 languages in order to reach more than 70 percent of the global population.\n\nLanguage barrier and e-guidance availability in the native language are the most important barriers when communicating with patients. E-guidance availability in various native languages should be considered a major priority by international medical and health organizations that are communicating with patients at the global level.<\/P>.", "doi": "10.2174/1574887116666211028145848", "pmid": "34967300", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "RRCT-EPUB-118603"}], "notes": [], "created": "2022-01-04T14:59:21.002Z", "modified": "2022-01-04T14:59:31.343Z"}, {"entity": "publication", "iuid": "7d83002c4ecd4eef919999fe1fdaca8a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d83002c4ecd4eef919999fe1fdaca8a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d83002c4ecd4eef919999fe1fdaca8a"}}, "title": "The impact of the COVID-19 pandemic on autoimmune diagnostics in Europe: A lesson to be learned.", "authors": [{"family": "Nagy", "given": "Eszter", "initials": "E"}, {"family": "Infantino", "given": "Maria", "initials": "M"}, {"family": "Bizzaro", "given": "Nicola", "initials": "N"}, {"family": "Andreeva", "given": "Hristina", "initials": "H"}, {"family": "Bontkes", "given": "Hetty J", "initials": "HJ"}, {"family": "Bossuyt", "given": "Xavier", "initials": "X"}, {"family": "Fabien", "given": "Nicole", "initials": "N"}, {"family": "Fischer", "given": "Katarzyna", "initials": "K"}, {"family": "Heijnen", "given": "Ingmar A F M", "initials": "IAFM"}, {"family": "Herold", "given": "Manfred", "initials": "M"}, {"family": "Kozmar", "given": "Ana", "initials": "A"}, {"family": "Kuhi", "given": "Liisa", "initials": "L"}, {"family": "L\u00f3pez-Hoyos", "given": "Marcos", "initials": "M"}, {"family": "Pullerits", "given": "Rille", "initials": "R"}, {"family": "Sousa", "given": "Maria Jos\u00e9 Rego", "initials": "MJR"}, {"family": "Tsirogianni", "given": "Alexandra", "initials": "A"}, {"family": "Damoiseaux", "given": "Jan", "initials": "J"}, {"family": "European Autoimmunity Standardisation Initiative", "given": "", "initials": ""}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "Autoimmun Rev", "issn": "1873-0183", "pages": "102985", "issn-l": null}, "abstract": "The first wave of COVID-19 pandemic has disrupted almost all areas of the health care services to some extent throughout the world. Although the negative impact of COVID-19 on patients with autoimmune diseases has also been recognized, available data in this regard are limited. In the current study of the European Autoimmunity Standardisation Initiative (EASI) we aimed to provide reliable data on the extent of the impact of COVID-19 pandemic on test requests for different autoantibodies in European countries.\n\nData on test numbers and on the number of positive results were collected in 97 clinical laboratories from 15 European countries on a monthly basis for the year before (2019) and the year during (2020) the COVID-19 pandemic.\n\nA reduction in the number of autoantibody tests was observed in all European countries in the year 2020 compared to 2019. The reduction affected all autoantibody tests with an overall decrease of 13%, ranging from 1.4% (Switzerland) to 25.5% (Greece). In all countries, the decrease was most pronounced during the first wave of the pandemic (March-May 2020) with an overall decrease in those three months of 45.2%. The most affected autoantibodies were those commonly requested by general practitioners (anti-tTG IgA (-71%), RF IgM (-66%) and ACPA (-61%)). In the second wave of the pandemic (October-December 2020) the decrease was less pronounced (6.8%). With respect to the rate of positive results, subtle differences were observed for distinct autoantibodies during the pandemic, but the total rate of positive results was similar in both years.\n\nOur study demonstrated a strong decrease in autoantibody requests during the first wave of the COVID-19 pandemic in 15 European countries. The second wave was characterized by a less pronounced impact, with some participating countries hardly affected, while some other countries experienced a second decline. The decrease was clearly associated with the level of lock-down and with the required adjustments in the health care systems in different countries, supporting the importance of an effective strategy for the coordination of autoimmune testing in challenging situations as the COVID-19 pandemic.", "doi": "10.1016/j.autrev.2021.102985", "pmid": "34718167", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1568-9972(21)00265-2"}], "notes": [], "created": "2021-11-01T19:53:22.570Z", "modified": "2021-11-01T19:53:22.584Z"}, {"entity": "publication", "iuid": "9f874862068d4cd791f845d47d2425ce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f874862068d4cd791f845d47d2425ce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f874862068d4cd791f845d47d2425ce"}}, "title": "The COVID-19 pandemic and ANCA-associated vasculitis - reports from the EUVAS meeting and EUVAS education forum.", "authors": [{"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Geetha", "given": "Duvuru", "initials": "D"}, {"family": "Smith", "given": "Rona M", "initials": "RM"}, {"family": "Egan", "given": "Allyson C", "initials": "AC"}, {"family": "Bajema", "given": "Ingeborg M", "initials": "IM"}, {"family": "Sch\u00f6nermarck", "given": "Ulf", "initials": "U"}, {"family": "Mahr", "given": "Alfred", "initials": "A"}, {"family": "Anders", "given": "Hans-Joachim", "initials": "HJ"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Cid", "given": "Maria C", "initials": "MC"}, {"family": "Jayne", "given": "David R W", "initials": "DRW"}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "Autoimmun Rev", "issn": "1873-0183", "pages": "102986", "issn-l": null}, "abstract": "The Coronavirus Disease 2019 (COVID-19) pandemic influenced the management of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. A paucity of data exists on outcome of patients with vasculitis following COVID-19, but mortality is higher than in the general population and comparable to patients undergoing haemodialysis or kidney transplant recipients (reported mortality rates of 20-25%). Delays in diagnosis have been reported, which are associated with sequelae such as dialysis-dependency. Management of ANCA-associated vasculitis has not changed with the aim to suppress disease activity and reduce burden of disease. The use of rituximab, an important and widely used agent, is associated with a more severe hospital course of COVID-19 and absence of antibodies following severe acute respiratory syndrome (SARS)-CoV-2 infections, which prone patients to re-infection. Reports on vaccine antibody response are scarce at the moment, but preliminary findings point towards an impaired immune response, especially when patients receive rituximab as part of their treatment. Seropositivity was reported in less than 20% of patients when rituximab was administered within the prior six months, and the antibody response correlated with CD19+ B-cell repopulation. A delay in maintenance doses, if disease activity allows, has been suggested using a CD19+ B-cell guided strategy. Other immunosuppressive measures, which are used in ANCA-associated vasculitis, also impair humoral and cellular vaccine responses. Regular measurements of vaccine response or a healthcare-policy time-based strategy are indicated to provide additional doses (\"booster\") of COVID-19 vaccines. This review summarizes a recent educational forum and a recent virtual meeting of the European Vasculitis Society (EUVAS) focusing on COVID-19.", "doi": "10.1016/j.autrev.2021.102986", "pmid": "34718165", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1568-9972(21)00266-4"}], "notes": [], "created": "2021-11-01T19:53:00.767Z", "modified": "2021-11-01T19:53:00.781Z"}, {"entity": "publication", "iuid": "56a3ee64de654942a1344e5dd2026dd1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56a3ee64de654942a1344e5dd2026dd1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56a3ee64de654942a1344e5dd2026dd1"}}, "title": "Susceptibility of Dog, Hamster, and Mouse Cells to the Replication-Competent Adenovirus 11p E1/E3 Green Fluorescence Protein Vector Has Implications for the Selection of Animal Vaccine Models.", "authors": [{"family": "Gokumakulapalle", "given": "Madhuri", "initials": "M"}, {"family": "Wang", "given": "Li", "initials": "L"}, {"family": "Mei", "given": "Ya-Fang", "initials": "YF"}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "Front Microbiol", "issn": "1664-302X", "volume": "12", "pages": "698999", "issn-l": null}, "abstract": "Human adenovirus (Ad)-vectored vaccines require viruses that can internalize into host cells and express the vaccine antigen. Evaluation of the expressed antigen in animal cells is a critical step in preclinical trials of viral vaccines. Due to the species specificity of Ads, it is difficult to find a suitable animal model. Thus, in this study, we compared the efficacy of Ad 11 prototype (Ad11p)-mediated green fluorescence protein (GFP) expression in cell lines of dog (MDCK), hamster (CHO), and mouse (McCoy and C127). Although these cell lines did not express the known primary cellular receptors for Ad11p virus infection (i.e., CD46), Ad11pE1GFP could infect and express GFP with various efficacies. For instance, it manifested relatively higher GFP expression in MDCK than in CHO, McCoy, and C127. However, infection leading to efficient viral release was not observed in any of the studied cell lines. The apparent differences were attributed to particularities of mouse and hamster cell lines, which might have led to the repression of viral DNA synthesis and to the low level of GFP expression mediated by Ad11pe3GFP. Moreover, our results revealed that undetectable hexon protein hampered the assembly of virus particles in CHO and MDCK cells. Ad11p differed from Ad5 in the ability for viral DNA synthesis when infecting CHO cells. Although a defective Ad has been successfully developed for SARS-CoV-2 vaccines in clinical applications, it has been difficult to generate one that can be used as an oral SARS-CoV-2 vaccine. Fortunately, our replication-competent Ad 11p vector might solve this problem. Regarding the use of Ad-vector candidates for vaccine purposes, this study demonstrates the selection of animal cell lines and determination of suitable virus doses in in vitro experiments.", "doi": "10.3389/fmicb.2021.698999", "pmid": "34777270", "labels": {"Type: Journal article": null, "Category: Vaccines": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8578929"}], "notes": [], "created": "2021-11-26T14:27:58.792Z", "modified": "2021-11-26T14:27:58.830Z"}, {"entity": "publication", "iuid": "dc2be6dc17694aa697b4280a36f1bda0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dc2be6dc17694aa697b4280a36f1bda0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dc2be6dc17694aa697b4280a36f1bda0"}}, "title": "Structural Modeling on the Determinants of Effectiveness of SOPs Containing COVID-19 in Mass Gatherings.", "authors": [{"family": "Basit", "given": "Abdul", "initials": "A"}, {"family": "Scholz", "given": "Miklas", "initials": "M"}, {"family": "Niazi", "given": "Abdul Aziz Khan", "initials": "AAK"}, {"family": "Qazi", "given": "Tehmina Fiaz", "initials": "TF"}, {"family": "Shaukat", "given": "Muhammad Zeeshan", "initials": "MZ"}, {"family": "Rao", "given": "Zia-Ur-Rehman", "initials": "ZU"}, {"family": "Mahmood", "given": "Asif", "initials": "A"}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "755221", "issn-l": "1664-1078"}, "abstract": "The study is aimed to analyze the determinants of the effectiveness of SOPs in mass gatherings for containing COVID-19. The overall design of the study involves a literature review, data collection by field survey, structural modeling, and analysis. The study is built on the experts' opinion of a focus group (representing people who recently participated in and are responsible for mass gatherings). The study uses the discussion of the literature review to identify the determinants, interpretive structural modeling (ISM) for developing and analyzing a structural model, and Matrice d'Impacts Croises Multiplication Appliqu\u00e9e a un Classement (MICMAC) for corroboration of results of the ISM/classification of determinants. From the literature review, a list of determinants is generated and verified by a panel of experts. The results of the ISM revealed that the determinants \"legal environment of the country,\" \"practicability of SOPs,\" \"perceived benefit of adapting SOPs,\" and \"possibilities of avoiding gathering\" occupied the top of the model, therefore, they are less critical determinants, whereas \"nature of gathering\" occupied the bottom of the model, and is thus the most critical determinant. The remaining determinants form the middle of the model, and are therefore moderately severe. The results of MICMAC show that the determinant \"perceived benefit of adapting SOPs\" is dependent, \"nature of gathering\" is independent, and all others are linked. The results of MICMAC implicitly substantiate the findings of the ISM. The overall results of the study show that \"nature of gathering\" is the key determinant. This research does not require a priori theory since it is a theory-building study that uses an inductive approach. It is based on real data and it is useful for local authorities, organizers, participants (attendees/visitors) of mass gatherings, health officials/regulators, researchers, and the community at large. This study has fundamental importance for planning and preparing for such events while ensuring the minimum risk of COVID-19 transmission.", "doi": "10.3389/fpsyg.2021.755221", "pmid": "34777157", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC8578903"}], "notes": [], "created": "2021-11-26T14:28:19.315Z", "modified": "2021-11-26T14:28:19.329Z"}, {"entity": "publication", "iuid": "e5bae109b5e84a9687da1506ae5c14c8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e5bae109b5e84a9687da1506ae5c14c8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e5bae109b5e84a9687da1506ae5c14c8"}}, "title": "SARS-CoV-2 and pregnancy outcomes under universal and non-universal testing in Sweden: register-based nationwide cohort study.", "authors": [{"family": "Stephansson", "given": "Olof", "initials": "O"}, {"family": "Pasternak", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Ahlberg", "given": "Mia", "initials": "M"}, {"family": "Hervius Askling", "given": "Helena", "initials": "H"}, {"family": "Aronsson", "given": "Bernice", "initials": "B"}, {"family": "Appelqvist", "given": "Emma", "initials": "E"}, {"family": "Jonsson", "given": "Jerker", "initials": "J"}, {"family": "Sengpiel", "given": "Verena", "initials": "V"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Norman", "given": "Mikael", "initials": "M"}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}, {"family": "Neovius", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "BJOG", "issn": "1471-0528", "issn-l": null}, "abstract": "To assess associations of SARS-CoV-2-infection and pregnancy outcomes considering testing policy and test-positivity-to-delivery-interval.\n\nNationwide cohort study.\n\nSweden.\n\nFrom the Pregnancy-Register we identified 88,593 singleton births, March 11, 2020-January 31, 2021, linked to data on SARS-CoV-2-positivity from the Public Health Agency, and information on neonatal care admission from the Neonatal Quality-Register. Adjusted odds ratios (aORs) were estimated stratified by testing-policy and test-positivity-to-delivery-interval.\n\n5-minute Apgar score, neonatal care admission, stillbirth and preterm birth.\n\nDuring pregnancy, SARS-CoV-2 test-positivity was 5.4% (794/14,665) under universal and 1.9% (1402/73,928) under non-universal testing. There were generally lower risks associated with SARS-CoV-2 under universal than non-universal testing. In women testing positive >10 days from delivery, generally no significant differences in risk were observed under either testing policy. Neonatal care admission was more common (15.3% vs. 8.0%; aOR 2.24, 1.62-3.11) in women testing positive \u226410 days before delivery under universal testing. There was no significant association with 5-minute Apgar score <7 (1.0% vs. 1.7%; aOR 0.64, 0.24-1.72) or stillbirth (0.3% vs. 0.4%; aOR 0.72, 0.10-5.20). Compared with term births (2.1%), test-positivity was higher in medically indicated preterm (5.7%; aOR 2.70, 1.60-4.58) but not significantly increased in spontaneous preterm birth (2.3%; aOR 1.12, 0.62-2.02).\n\nTesting policy and timing of test positivity impact associations between SARS-CoV-2 positivity and pregnancy outcomes. Under non-universal testing, women with complications near delivery are more likely to be tested than women without complications, thereby inflating any association with adverse pregnancy outcomes compared to findings under universal testing.", "doi": "10.1111/1471-0528.16990", "pmid": "34706148", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:45:48.410Z", "modified": "2021-11-01T19:45:54.393Z"}, {"entity": "publication", "iuid": "5924041381054e26b5f234589e3c0477", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5924041381054e26b5f234589e3c0477.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5924041381054e26b5f234589e3c0477"}}, "title": "NMR-Based Analysis of Nanobodies to SARS-CoV-2 Nsp9 Reveals a Possible Antiviral Strategy Against COVID-19.", "authors": [{"family": "Esposito", "given": "Gennaro", "initials": "G"}, {"family": "Hunashal", "given": "Yamanappa", "initials": "Y"}, {"family": "Percipalle", "given": "Mathias", "initials": "M"}, {"family": "Venit", "given": "Tomas", "initials": "T"}, {"family": "Dieng", "given": "Mame Massar", "initials": "MM"}, {"family": "Fogolari", "given": "Federico", "initials": "F"}, {"family": "Hassanzadeh", "given": "Gholamreza", "initials": "G"}, {"family": "Piano", "given": "Fabio", "initials": "F"}, {"family": "Gunsalus", "given": "Kristin C", "initials": "KC"}, {"family": "Idaghdour", "given": "Youssef", "initials": "Y"}, {"family": "Percipalle", "given": "Piergiorgio", "initials": "P"}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "Adv Biol (Weinh)", "issn": "2701-0198", "pages": "e2101113", "issn-l": null}, "abstract": "Following the entry into the host cell, SARS-CoV-2 replication is mediated by the replication transcription complex (RTC) assembled through a number of nonstructural proteins (Nsps). A monomeric form of Nsp9 is particularly important for RTC assembly and function. In the present study, 136 unique nanobodies targeting Nsp9 are generated. Several nanobodies belonging to different B-cell lineages are expressed, purified, and characterized. Results from immunoassays applied to purified Nsp9 and neat saliva from coronavirus disease (COVID-19) patients show that these nanobodies effectively and specifically recognize both recombinant and endogenous Nsp9. Nuclear magnetic resonance analyses supported by molecular dynamics reveal a composite Nsp9 oligomerization pattern and demonstrate that both nanobodies stabilize the tetrameric form of wild-type Nsp9 also identifying the epitopes on the tetrameric assembly. These results can have important implications in the potential use of these nanobodies to combat viral replication.", "doi": "10.1002/adbi.202101113", "pmid": "34705339", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:39:08.657Z", "modified": "2021-11-01T19:44:19.968Z"}, {"entity": "publication", "iuid": "49a2fc525b8946b7a7913b62b72d1849", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49a2fc525b8946b7a7913b62b72d1849.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49a2fc525b8946b7a7913b62b72d1849"}}, "title": "Infection of Brain Pericytes Underlying Neuropathology of COVID-19 Patients.", "authors": [{"family": "Bocci", "given": "Matteo", "initials": "M", "orcid": "0000-0002-8774-0006", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c3ba1259efde4518bcdb59555b8a536e.json"}}, {"family": "Oudenaarden", "given": "Clara", "initials": "C", "orcid": "0000-0002-5466-0755", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75886cf472ee4475b742994021bb64c8.json"}}, {"family": "S\u00e0enz-Sard\u00e0", "given": "Xavier", "initials": "X"}, {"family": "Simr\u00e9n", "given": "Joel", "initials": "J", "orcid": "0000-0001-5081-6604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00690c8e16a545aea824cdf580837500.json"}}, {"family": "Ed\u00e9n", "given": "Arvid", "initials": "A"}, {"family": "Sj\u00f6lund", "given": "Jonas", "initials": "J", "orcid": "0000-0002-6992-3415", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5bf3daabd44d45efa72697934ad730b7.json"}}, {"family": "M\u00f6ller", "given": "Christina", "initials": "C"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Englund", "given": "Elisabet", "initials": "E", "orcid": "0000-0002-2708-2443", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b5ac92c5d404356b843be1973ea4922.json"}}, {"family": "Pietras", "given": "Kristian", "initials": "K", "orcid": "0000-0001-6738-4705", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5d4c2cbb9ca49a7a9664c83e383c695.json"}}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "issn-l": null, "volume": "22", "issue": "21", "pages": "11622"}, "abstract": "A wide range of neurological manifestations have been associated with the development of COVID-19 following SARS-CoV-2 infection. However, the etiology of the neurological symptomatology is still largely unexplored. Here, we used state-of-the-art multiplexed immunostaining of human brains (n = 6 COVID-19, median age = 69.5 years; n = 7 control, median age = 68 years) and demonstrated that expression of the SARS-CoV-2 receptor ACE2 is restricted to a subset of neurovascular pericytes. Strikingly, neurological symptoms were exclusive to, and ubiquitous in, patients that exhibited moderate to high ACE2 expression in perivascular cells. Viral dsRNA was identified in the vascular wall and paralleled by perivascular inflammation, as signified by T cell and macrophage infiltration. Furthermore, fibrinogen leakage indicated compromised integrity of the blood-brain barrier. Notably, cerebrospinal fluid from additional 16 individuals (n = 8 COVID-19, median age = 67 years; n = 8 control, median age = 69.5 years) exhibited significantly lower levels of the pericyte marker PDGFR\u03b2 in SARS-CoV-2-infected cases, indicative of disrupted pericyte homeostasis. We conclude that pericyte infection by SARS-CoV-2 underlies virus entry into the privileged central nervous system space, as well as neurological symptomatology due to perivascular inflammation and a locally compromised blood-brain barrier.", "doi": "10.3390/ijms222111622", "pmid": "34769052", "labels": {"Type: Journal article": null, "Category: Health": null, "Funder: H2020": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC8583965"}, {"db": "pii", "key": "ijms222111622"}], "notes": [], "created": "2021-11-26T15:11:17.222Z", "modified": "2023-06-19T14:45:33.615Z"}, {"entity": "publication", "iuid": "4deb3e9fe22f428bb2a86ea93ae98cc8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4deb3e9fe22f428bb2a86ea93ae98cc8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4deb3e9fe22f428bb2a86ea93ae98cc8"}}, "title": "Experience of the COVID-19 pandemic as lived by patients with hip and knee osteoarthritis: an Italian qualitative study.", "authors": [{"family": "Battista", "given": "Simone", "initials": "S", "orcid": "0000-0002-7471-1951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/787958b5579949919d584b1ef60e6eb2.json"}}, {"family": "Dell'Isola", "given": "Andrea", "initials": "A", "orcid": "0000-0002-0319-458X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d8ea417b7c447f8bc4da9f47f9feb39.json"}}, {"family": "Manoni", "given": "Mattia", "initials": "M"}, {"family": "Englund", "given": "Martin", "initials": "M"}, {"family": "Palese", "given": "Alvisa", "initials": "A", "orcid": "0000-0002-3508-844X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea400153bf344f98a5e06367b0442e17.json"}}, {"family": "Testa", "given": "Marco", "initials": "M"}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "10", "pages": "e053194", "issn-l": "2044-6055"}, "abstract": "To examine the experience of the COVID-19 pandemic as lived by people with hip and knee osteoarthritis (OA), in Italy.\n\nA qualitative study based on semi-structured interviews.\n\nUrban and suburban areas in northern Italy.\n\nA total of 11 people with OA were enrolled through a purposeful sampling and completed the study.\n\nThe experience of Italian people with OA during the COVID-19 pandemic.\n\nFour themes were brought to the forefront from the analysis of the interviews. (1) Being Stressed for the Limited Social Interactions and for the Family Members at High Risk of Infection, as the interviewees were frustrated because they could not see their loved ones or felt a sense of apprehension for their relatives. (2) Recurring Strategies to Cope with the Pandemic such as an active acceptance towards the situation. (3) Being Limited in the Possibility of Undergoing OA Complementary Treatments and Other Routine Medical Visits. (4) Being Unaware of the Importance of Physical Activity as First-Line Interventions which was an attitude already present before the pandemic.\n\nThe COVID-19 pandemic and related restrictions impacted the quality of life and the care of individuals with hip and knee OA. The social sphere seemed to be the most hindered. However, the interviewees developed a good level of acceptance to deal with the pandemic. When it came to their care, they faced a delay of routine medical visits not related to OA and of other complementary treatments (eg, physical therapies) to manage OA. Finally, a controversial result that emerged from these interviews was that first-line interventions for OA (ie, therapeutic exercise) was not sought by the interviewees, regardless of the restrictions dictated by the pandemic. Policy-making strategies are thus necessary to support the awareness of the importance of such interventions.", "doi": "10.1136/bmjopen-2021-053194", "pmid": "34706962", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-053194"}, {"db": "pmc", "key": "PMC8551748"}], "notes": [], "created": "2021-11-01T19:47:22.538Z", "modified": "2021-11-01T19:47:22.639Z"}, {"entity": "publication", "iuid": "e510117a965e4b958a1a37c706e5f11e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e510117a965e4b958a1a37c706e5f11e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e510117a965e4b958a1a37c706e5f11e"}}, "title": "Brain MRI and neuropsychological findings at long-term follow-up after COVID-19 hospitalisation: an observational cohort study.", "authors": [{"family": "Hellgren", "given": "Lovisa", "initials": "L", "orcid": "0000-0003-4099-9456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45a3650707574e258665a54751ae26ba.json"}}, {"family": "Birberg Thornberg", "given": "Ulrika", "initials": "U"}, {"family": "Samuelsson", "given": "Kersti", "initials": "K"}, {"family": "Levi", "given": "Richard", "initials": "R"}, {"family": "Divanoglou", "given": "Anestis", "initials": "A"}, {"family": "Blystad", "given": "Ida", "initials": "I"}], "type": "journal article", "published": "2021-10-27", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "10", "pages": "e055164", "issn-l": "2044-6055"}, "abstract": "To report findings on brain MRI and neurocognitive function, as well as persisting fatigue at long-term follow-up after COVID-19 hospitalisation in patients identified as high risk for affection of the central nervous system.\n\nAmbidirectional observational cohort study.\n\nAll 734 patients from a regional population in Sweden with a laboratory-confirmed COVID-19 diagnosis admitted to hospital during the period 1 March to 31 May 2020.\n\nA subgroup (n=185) with persisting symptoms still interfering with daily life at a telephone follow-up 4 months after discharge were invited for a medical and neuropsychological evaluation. Thirty-five of those who were assessed with a neurocognitive test battery at the clinical visit, and presented a clinical picture concerning for COVID-19-related brain pathology, were further investigated by brain MRI.\n\nFindings on brain MRI, neurocognitive test results and reported fatigue.\n\nTwenty-five patients (71%) had abnormalities on MRI; multiple white matter lesions were the most common finding. Sixteen patients (46%) demonstrated impaired neurocognitive function, of which 10 (29%) had severe impairment. Twenty-six patients (74%) reported clinically significant fatigue. Patients with abnormalities on MRI had a lower Visuospatial Index (p=0.031) compared with the group with normal MRI findings.\n\nIn this group of patients selected to undergo MRI after a clinical evaluation, a majority of patients had abnormal MRI and/or neurocognitive test results. Abnormal findings were not restricted to patients with severe disease.", "doi": "10.1136/bmjopen-2021-055164", "pmid": "34706965", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-055164"}, {"db": "pmc", "key": "PMC8551746"}], "notes": [], "created": "2021-11-01T19:47:38.514Z", "modified": "2021-11-01T19:47:38.573Z"}, {"entity": "publication", "iuid": "8ea921e8ebb1479ca21c1bc2cb4a4aba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ea921e8ebb1479ca21c1bc2cb4a4aba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ea921e8ebb1479ca21c1bc2cb4a4aba"}}, "title": "The impact of a COVID-19 lockdown on work productivity under good and poor compliance.", "authors": [{"family": "Ohrnberger", "given": "Julius", "initials": "J"}, {"family": "Segal", "given": "Alexa Blair", "initials": "AB"}, {"family": "Forchini", "given": "Giovanni", "initials": "G"}, {"family": "Miraldo", "given": "Marisa", "initials": "M"}, {"family": "Skarp", "given": "Janetta", "initials": "J"}, {"family": "Nedjati-Gilani", "given": "Gemma", "initials": "G"}, {"family": "Laydon", "given": "Daniel J", "initials": "DJ"}, {"family": "Ghani", "given": "Azra", "initials": "A"}, {"family": "Ferguson", "given": "Neil M", "initials": "NM"}, {"family": "Hauck", "given": "Katharina", "initials": "K"}], "type": "journal article", "published": "2021-10-26", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": "31", "issue": "5", "pages": "1009-1015"}, "abstract": "In response to the COVID-19 pandemic, governments across the globe have imposed strict social distancing measures. Public compliance to such measures is essential for their success, yet the economic consequences of compliance are unknown. This is the first study to analyze the effects of good compliance compared with poor compliance to a COVID-19 suppression strategy (i.e. lockdown) on work productivity.\r\n\r\nWe estimate the differences in work productivity comparing a scenario of good compliance with one of poor compliance to the UK government COVID-19 suppression strategy. We use projections of the impact of the UK suppression strategy on mortality and morbidity from an individual-based epidemiological model combined with an economic model representative of the labour force in Wales and England.\r\n\r\nWe find that productivity effects of good compliance significantly exceed those of poor compliance and increase with the duration of the lockdown. After 3 months of the lockdown, work productivity in good compliance is \u00a3398.58 million higher compared with that of poor compliance; 75% of the differences is explained by productivity effects due to morbidity and non-health reasons and 25% attributed to avoided losses due to pre-mature mortality.\r\n\r\nGood compliance to social distancing measures exceeds positive economic effects, in addition to health benefits. This is an important finding for current economic and health policy. It highlights the importance to set clear guidelines for the public, to build trust and support for the rules and if necessary, to enforce good compliance to social distancing measures.", "doi": "10.1093/eurpub/ckab138", "pmid": "34358291", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6343457"}, {"db": "pmc", "key": "PMC8385936"}], "notes": [], "created": "2021-08-11T14:38:19.897Z", "modified": "2021-11-18T13:28:17.534Z"}, {"entity": "publication", "iuid": "386040da818e4b41895292a89e9a70d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/386040da818e4b41895292a89e9a70d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/386040da818e4b41895292a89e9a70d9"}}, "title": "Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure", "authors": [{"family": "Rando", "given": "Halie M", "initials": "HM", "orcid": "0000-0001-7688-1770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b5a9f4ec1bd48579abca9895dab3ea7.json"}}, {"family": "MacLean", "given": "Adam L", "initials": "AL"}, {"family": "Lee", "given": "Alexandra J", "initials": "AJ"}, {"family": "Lordan", "given": "Ronan", "initials": "R", "orcid": "0000-0001-9668-3368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0126a49dfcdf49fcb53041fbdcd91706.json"}}, {"family": "Ray", "given": "Sandipan", "initials": "S"}, {"family": "Bansal", "given": "Vikas", "initials": "V"}, {"family": "Skelly", "given": "Ashwin N", "initials": "AN"}, {"family": "Sell", "given": "Elizabeth", "initials": "E"}, {"family": "Dziak", "given": "John J", "initials": "JJ"}, {"family": "Shinholster", "given": "Lamonica", "initials": "L"}, {"family": "D\u2019Agostino McGowan", "given": "Lucy", "initials": "L"}, {"family": "Ben Guebila", "given": "Marouen", "initials": "M"}, {"family": "Wellhausen", "given": "Nils", "initials": "N"}, {"family": "Knyazev", "given": "Sergey", "initials": "S"}, {"family": "Boca", "given": "Simina M", "initials": "SM"}, {"family": "Capone", "given": "Stephen", "initials": "S"}, {"family": "Qi", "given": "Yanjun", "initials": "Y"}, {"family": "Park", "given": "YoSon", "initials": "Y"}, {"family": "Mai", "given": "David", "initials": "D"}, {"family": "Sun", "given": "Yuchen", "initials": "Y"}, {"family": "Boerckel", "given": "Joel D", "initials": "JD"}, {"family": "Brueffer", "given": "Christian", "initials": "C"}, {"family": "Byrd", "given": "James Brian", "initials": "JB"}, {"family": "Kamil", "given": "Jeremy P", "initials": "JP", "orcid": "0000-0001-8422-7656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa225803435a4d7b803176e2ccfbef19.json"}}, {"family": "Wang", "given": "Jinhui", "initials": "J"}, {"family": "Velazquez", "given": "Ryan", "initials": "R"}, {"family": "Szeto", "given": "Gregory L", "initials": "GL"}, {"family": "Barton", "given": "John P", "initials": "JP"}, {"family": "Goel", "given": "Rishi Raj", "initials": "RR"}, {"family": "Mangul", "given": "Serghei", "initials": "S"}, {"family": "Lubiana", "given": "Tiago", "initials": "T"}, {"family": "Gitter", "given": "Anthony", "initials": "A"}, {"family": "Greene", "given": "Casey S", "initials": "CS", "orcid": "0000-0001-8713-9213", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42aaaac8b65642538f28f9cd2045ab8d.json"}}, {"family": "None", "given": "", "initials": ""}], "type": "journal-article", "published": "2021-10-26", "journal": {"title": "mSystems", "issn": "2379-5077", "issn-l": null, "volume": "6", "issue": "5", "pages": null}, "abstract": null, "doi": "10.1128/msystems.00095-21", "pmid": null, "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:37:06.978Z", "modified": "2021-11-18T14:28:27.267Z"}, {"entity": "publication", "iuid": "70243d223f1848d1967e89a92973652a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70243d223f1848d1967e89a92973652a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70243d223f1848d1967e89a92973652a"}}, "title": "Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms.", "authors": [{"family": "Zhu", "given": "Rongjia", "initials": "R", "orcid": "0000-0003-3165-2813", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6f44e080388045cfb694fe567aa26b16.json"}}, {"family": "Yan", "given": "Tingdong", "initials": "T"}, {"family": "Feng", "given": "Yingmei", "initials": "Y", "orcid": "0000-0001-5248-0155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/975beb8e77c84ab1b4de7b8faaf1c24b.json"}}, {"family": "Liu", "given": "Yan", "initials": "Y"}, {"family": "Cao", "given": "Hongcui", "initials": "H", "orcid": "0000-0002-6604-6867", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2296fd365154488bba2c052485f370d0.json"}}, {"family": "Peng", "given": "Gongxin", "initials": "G"}, {"family": "Yang", "given": "Yanlei", "initials": "Y"}, {"family": "Xu", "given": "Zhen", "initials": "Z"}, {"family": "Liu", "given": "Jingqi", "initials": "J"}, {"family": "Hou", "given": "Wei", "initials": "W"}, {"family": "Wang", "given": "Xiaoyue", "initials": "X"}, {"family": "Li", "given": "Zhe", "initials": "Z"}, {"family": "Deng", "given": "Luchan", "initials": "L"}, {"family": "Wang", "given": "Shihua", "initials": "S"}, {"family": "Li", "given": "Jing", "initials": "J"}, {"family": "Han", "given": "Qin", "initials": "Q"}, {"family": "Li", "given": "Hongling", "initials": "H"}, {"family": "Shan", "given": "Guangliang", "initials": "G"}, {"family": "Cao", "given": "Yinghao", "initials": "Y"}, {"family": "An", "given": "Xingyan", "initials": "X"}, {"family": "Yan", "given": "Jianshe", "initials": "J"}, {"family": "Zhang", "given": "Zhonghui", "initials": "Z"}, {"family": "Li", "given": "Huafei", "initials": "H"}, {"family": "Qu", "given": "Xuebin", "initials": "X"}, {"family": "Zhu", "given": "Jiaqi", "initials": "J"}, {"family": "Zhou", "given": "Shumin", "initials": "S"}, {"family": "Wang", "given": "Jiao", "initials": "J"}, {"family": "Zhang", "given": "Fengchun", "initials": "F"}, {"family": "Gao", "given": "Jinming", "initials": "J"}, {"family": "Jin", "given": "Ronghua", "initials": "R", "orcid": "0000-0002-6035-2425", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af992bd4085247d68012ae3996daa0bd.json"}}, {"family": "Xu", "given": "Dayong", "initials": "D"}, {"family": "Ma", "given": "Yan-Qing", "initials": "YQ", "orcid": "0000-0002-0573-7701", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b1665bdbfe34e6ca10bbd4dfd63470f.json"}}, {"family": "Huang", "given": "Tao", "initials": "T"}, {"family": "Peng", "given": "Shuang", "initials": "S"}, {"family": "Zheng", "given": "Zhi", "initials": "Z"}, {"family": "Stambler", "given": "Ilia", "initials": "I"}, {"family": "Gilson", "given": "Eric", "initials": "E"}, {"family": "Lim", "given": "Lee Wei", "initials": "LW"}, {"family": "Moskalev", "given": "Alexey", "initials": "A", "orcid": "0000-0002-3248-1633", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18eb8535023143ee9ec9f80ca3dc7185.json"}}, {"family": "Cano", "given": "Antonio", "initials": "A"}, {"family": "Chakrabarti", "given": "Sasanka", "initials": "S"}, {"family": "Ulfhake", "given": "Brun", "initials": "B"}, {"family": "Su", "given": "Huanxing", "initials": "H"}, {"family": "Xu", "given": "Haoying", "initials": "H"}, {"family": "Xu", "given": "Sihuan", "initials": "S"}, {"family": "Wei", "given": "Feng", "initials": "F"}, {"family": "Brown-Borg", "given": "Holly M", "initials": "HM"}, {"family": "Min", "given": "Kyung-Jin", "initials": "KJ"}, {"family": "Ellison-Hughes", "given": "Georgina", "initials": "G"}, {"family": "Caruso", "given": "Calogero", "initials": "C"}, {"family": "Jin", "given": "Kunlin", "initials": "K"}, {"family": "Zhao", "given": "Robert Chunhua", "initials": "RC", "orcid": "0000-0002-4609-8424", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d1fca3775f643f9992e48a753ca1a37.json"}}], "type": "journal article", "published": "2021-10-26", "journal": {"title": "Cell Res", "issn": "1748-7838", "issn-l": null}, "abstract": "The infusion of coronavirus disease 2019 (COVID-19) patients with mesenchymal stem cells (MSCs) potentially improves clinical symptoms, but the underlying mechanism remains unclear. We conducted a randomized, single-blind, placebo-controlled (29 patients/group) phase II clinical trial to validate previous findings and explore the potential mechanisms. Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay (P = 0.0198) and less time required for symptoms remission (P = 0.0194) than those who received placebo. Based on chest images, both severe and critical patients treated with MSCs showed improvement by day 7 (P = 0.0099) and day 21 (P = 0.0084). MSC-treated patients had fewer adverse events. MSC infusion reduced the levels of C-reactive protein, proinflammatory cytokines, and neutrophil extracellular traps (NETs) and promoted the maintenance of SARS-CoV-2-specific antibodies. To explore how MSCs modulate the immune system, we employed single-cell RNA sequencing analysis on peripheral blood. Our analysis identified a novel subpopulation of VNN2+ hematopoietic stem/progenitor-like (HSPC-like) cells expressing CSF3R and PTPRE that were mobilized following MSC infusion. Genes encoding chemotaxis factors - CX3CR1 and L-selectin - were upregulated in various immune cells. MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro. In addition, an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling. Together, our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis.", "doi": "10.1038/s41422-021-00573-y", "pmid": "34702946", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41422-021-00573-y"}, {"db": "pmc", "key": "PMC8546390"}], "notes": [], "created": "2021-11-01T19:40:40.141Z", "modified": "2021-11-01T19:40:40.407Z"}, {"entity": "publication", "iuid": "c91b5940918046b7b7baf2c3432e336b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c91b5940918046b7b7baf2c3432e336b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c91b5940918046b7b7baf2c3432e336b"}}, "title": "Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort", "authors": [{"family": "Carapito", "given": "Raphael", "initials": "R"}, {"family": "Li", "given": "Richard", "initials": "R"}, {"family": "Helms", "given": "Julie", "initials": "J"}, {"family": "Carapito", "given": "Christine", "initials": "C"}, {"family": "Gujja", "given": "Sharvari", "initials": "S"}, {"family": "Rolli", "given": "V\u00e9ronique", "initials": "V"}, {"family": "Guimaraes", "given": "Raony", "initials": "R"}, {"family": "Malagon-Lopez", "given": "Jose", "initials": "J"}, {"family": "Spinnhirny", "given": "Perrine", "initials": "P"}, {"family": "Lederle", "given": "Alexandre", "initials": "A"}, {"family": "Mohseninia", "given": "Razieh", "initials": "R"}, {"family": "Hirschler", "given": "Aur\u00e9lie", "initials": "A"}, {"family": "Muller", "given": "Leslie", "initials": "L"}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Gervais", "given": "Adrian", "initials": "A"}, {"family": "Zhang", "given": "Qian", "initials": "Q"}, {"family": "Danion", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Ruch", "given": "Yvon", "initials": "Y"}, {"family": "Schenck", "given": "Maleka", "initials": "M"}, {"family": "Collange", "given": "Olivier", "initials": "O"}, {"family": "Chamaraux-Tran", "given": "Thi\u00ean Nga", "initials": "TN"}, {"family": "Molitor", "given": "Anne", "initials": "A"}, {"family": "Pichot", "given": "Ang\u00e9lique", "initials": "A"}, {"family": "Bernard", "given": "Alice", "initials": "A"}, {"family": "Tahar", "given": "Ouria", "initials": "O"}, {"family": "Bibi-Triki", "given": "Sabrina", "initials": "S"}, {"family": "Wu", "given": "Haiguo", "initials": "H"}, {"family": "Paul", "given": "Nicod\u00e8me", "initials": "N"}, {"family": "Mayeur", "given": "Sylvain", "initials": "S"}, {"family": "Larnicol", "given": "Annabel", "initials": "A"}, {"family": "Laumond", "given": "G\u00e9raldine", "initials": "G"}, {"family": "Frappier", "given": "Julia", "initials": "J"}, {"family": "Schmidt", "given": "Sylvie", "initials": "S"}, {"family": "Hanauer", "given": "Antoine", "initials": "A"}, {"family": "Macquin", "given": "C\u00e9cile", "initials": "C"}, {"family": "Stemmelen", "given": "Tristan", "initials": "T"}, {"family": "Simons", "given": "Michael", "initials": "M"}, {"family": "Mariette", "given": "Xavier", "initials": "X"}, {"family": "Hermine", "given": "Olivier", "initials": "O"}, {"family": "Fafi-Kremer", "given": "Samira", "initials": "S"}, {"family": "Goichot", "given": "Bernard", "initials": "B"}, {"family": "Drenou", "given": "Bernard", "initials": "B"}, {"family": "Kuteifan", "given": "Khaldoun", "initials": "K"}, {"family": "Pottecher", "given": "Julien", "initials": "J"}, {"family": "Mertes", "given": "Paul Michel", "initials": "PM"}, {"family": "Kailasan", "given": "Shweta", "initials": "S"}, {"family": "Aman", "given": "M Javad", "initials": "MJ"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Thomas", "given": "Anne", "initials": "A"}, {"family": "Viari", "given": "Alain", "initials": "A"}, {"family": "Sanlaville", "given": "Damien", "initials": "D"}, {"family": "Schneider", "given": "Francis", "initials": "F"}, {"family": "Sibilia", "given": "Jean", "initials": "J"}, {"family": "Tharaux", "given": "Pierre Louis", "initials": "PL"}, {"family": "Casanova", "given": "Jean Laurent", "initials": "JL"}, {"family": "Hansmann", "given": "Yves", "initials": "Y"}, {"family": "Lidar", "given": "Daniel", "initials": "D"}, {"family": "Radosavljevic", "given": "Mirjana", "initials": "M"}, {"family": "Gulcher", "given": "Jeffrey R", "initials": "JR"}, {"family": "Meziani", "given": "Ferhat", "initials": "F"}, {"family": "Moog", "given": "Christiane", "initials": "C"}, {"family": "Chittenden", "given": "Thomas W", "initials": "TW"}, {"family": "Bahram", "given": "Seiamak", "initials": "S"}], "type": "journal-article", "published": "2021-10-26", "journal": {"title": "Sci. Transl. Med.", "issn": "1946-6234", "pages": "eabj7521", "issn-l": null}, "abstract": "[Figure: see text].", "doi": "10.1126/scitranslmed.abj7521", "pmid": "34698500", "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "GEO", "key": "GSE172114", "description": "RNA-seq datasets"}, {"db": "URL", "key": "http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD025265", "description": "Proteomics data are available in the ProteomeXchange Consortium database (identifier PXD025265)"}, {"db": "URL", "key": "https://zenodo.org/record/5557611#.YZZcmC8w3OQ", "description": "Codes used for analysis"}], "notes": [], "created": "2021-10-26T18:35:08.060Z", "modified": "2021-11-18T16:24:43.998Z"}, {"entity": "publication", "iuid": "fa8cdbf2d54240edb509d2e0799d6ae8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa8cdbf2d54240edb509d2e0799d6ae8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa8cdbf2d54240edb509d2e0799d6ae8"}}, "title": "GRAd-COV2, a gorilla adenovirus-based candidate vaccine against COVID-19, is safe and immunogenic in younger and older adults", "authors": [{"family": "Lanini", "given": "Simone", "initials": "S"}, {"family": "Capone", "given": "Stefania", "initials": "S"}, {"family": "Antinori", "given": "Andrea", "initials": "A"}, {"family": "Milleri", "given": "Stefano", "initials": "S"}, {"family": "Nicastri", "given": "Emanuele", "initials": "E"}, {"family": "Camerini", "given": "Roberto", "initials": "R"}, {"family": "Agrati", "given": "Chiara", "initials": "C"}, {"family": "Castilletti", "given": "Concetta", "initials": "C"}, {"family": "Mori", "given": "Federica", "initials": "F"}, {"family": "Sacchi", "given": "Alessandra", "initials": "A"}, {"family": "Matusali", "given": "Giulia", "initials": "G"}, {"family": "Gagliardini", "given": "Roberta", "initials": "R"}, {"family": "Ammendola", "given": "Virginia", "initials": "V"}, {"family": "Cimini", "given": "Eleonora", "initials": "E"}, {"family": "Grazioli", "given": "Fabiana", "initials": "F"}, {"family": "Scorzolini", "given": "Laura", "initials": "L"}, {"family": "Napolitano", "given": "Federico", "initials": "F"}, {"family": "Plazzi", "given": "Maria M", "initials": "MM"}, {"family": "Soriani", "given": "Marco", "initials": "M"}, {"family": "De Luca", "given": "Aldo", "initials": "A"}, {"family": "Battella", "given": "Simone", "initials": "S"}, {"family": "Sommella", "given": "Andrea", "initials": "A"}, {"family": "Contino", "given": "Alessandra M", "initials": "AM"}, {"family": "Barra", "given": "Federica", "initials": "F"}, {"family": "Gentile", "given": "Michela", "initials": "M"}, {"family": "Raggioli", "given": "Angelo", "initials": "A"}, {"family": "Shi", "given": "Yufang", "initials": "Y"}, {"family": "Girardi", "given": "Enrico", "initials": "E"}, {"family": "Maeurer", "given": "Markus", "initials": "M"}, {"family": "Capobianchi", "given": "Maria R", "initials": "MR"}, {"family": "Vaia", "given": "Francesco", "initials": "F"}, {"family": "Piacentini", "given": "Mauro", "initials": "M"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}, {"family": "Vitelli", "given": "Alessandra", "initials": "A"}, {"family": "Colloca", "given": "Stefano", "initials": "S"}, {"family": "Folgori", "given": "Antonella", "initials": "A"}, {"family": "Ippolito", "given": "Giuseppe", "initials": "G"}, {"family": "Ottou", "given": "Sandrine", "initials": "S"}, {"family": "Vita", "given": "Serena", "initials": "S"}, {"family": "Vergori", "given": "Alessandra", "initials": "A"}, {"family": "D\u2019Abramo", "given": "Alessandra", "initials": "A"}, {"family": "Petrecchia", "given": "Antonella", "initials": "A"}, {"family": "Montaldo", "given": "Chiara", "initials": "C"}, {"family": "Scalise", "given": "Emilio", "initials": "E"}, {"family": "Grassi", "given": "Germana", "initials": "G"}, {"family": "Casetti", "given": "Rita", "initials": "R"}, {"family": "Bordoni", "given": "Veronica", "initials": "V"}, {"family": "Notari", "given": "Stefania", "initials": "S"}, {"family": "Colavita", "given": "Francesca", "initials": "F"}, {"family": "Meschi", "given": "Silvia", "initials": "S"}, {"family": "Lapa", "given": "Daniele", "initials": "D"}, {"family": "Bordi", "given": "Licia", "initials": "L"}, {"family": "Murachelli", "given": "Silvia", "initials": "S"}, {"family": "Tambasco", "given": "Teresa", "initials": "T"}, {"family": "Grillo", "given": "Alessandra", "initials": "A"}, {"family": "Masone", "given": "Erminia", "initials": "E"}, {"family": "Marchioni", "given": "Elisa", "initials": "E"}, {"family": "Bardhi", "given": "Dorian", "initials": "D"}, {"family": "Porzio", "given": "Ottavia", "initials": "O"}, {"family": "Cocca", "given": "Francesca", "initials": "F"}, {"family": "Murachelli", "given": "Silvia", "initials": "S"}, {"family": "Turrini", "given": "Irene", "initials": "I"}, {"family": "Malescio", "given": "Feliciana", "initials": "F"}, {"family": "Ziviani", "given": "Luigi", "initials": "L"}, {"family": "Lawlor", "given": "Rita", "initials": "R"}, {"family": "Poli", "given": "Federica", "initials": "F"}, {"family": "Martire", "given": "Federica", "initials": "F"}, {"family": "Zamboni", "given": "Daniela", "initials": "D"}, {"family": "Mazzaferri", "given": "Flavia", "initials": "F"}], "type": "journal-article", "published": "2021-10-26", "journal": {"title": "Sci. Transl. Med.", "issn": "1946-6234", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1126/scitranslmed.abj1996", "pmid": "34698501", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:36:34.474Z", "modified": "2021-11-29T06:07:56.622Z"}, {"entity": "publication", "iuid": "c918a56ef26044f7af5082f1360adfd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c918a56ef26044f7af5082f1360adfd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c918a56ef26044f7af5082f1360adfd0"}}, "title": "A more frequent disease monitorering but no increased disease activity in patients with inflammatory bowel disease during the first year of the SARS-CoV-2 pandemic. A retrospective study.", "authors": [{"family": "Lindhagen", "given": "Sara", "initials": "S"}, {"family": "Karling", "given": "Pontus", "initials": "P", "orcid": "0000-0002-5607-0118", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e40faefd22e41449b1a7d717efead99.json"}}], "type": "journal article", "published": "2021-10-26", "journal": {"title": "Scand J Gastroenterol", "issn": "1502-7708", "pages": "1-6", "issn-l": null}, "abstract": "The SARS-CoV-2 pandemic abruptly switched the healthcare service for patients with inflammatory bowel disease (IBD) towards a telemedicine dominated approach. The aim of this study was to investigate the impact of this switch on monitoring of patients and on disease activity.\n\nThe pre-pandemic year included 868 patients and the first year of the pandemic included 891 patients. Medical records were retrospectively checked for contacts, changes in medical treatment, performed fecal calprotectin (FC) tests and colonoscopies.\n\nThe scheduled follow-up visits to a doctor for patients with IBD shifted from mostly face-to-face pre-pandemic (from 389 to 118 appointments) to mostly telephone-based during the pandemic (from 13 to 423 appointments). There was a 21.3% increase in mean overall scheduled health contacts (p < .001) and a 20.0% increase for the mean number of FC tests (p < .001) in the year of the pandemic compared to the pre-pandemic year. The proportion of patients who had a surveillance colonoscopy was significant lower in the year of the pandemic compared to the pre-pandemic year (12.7% vs 20.1%; p = .002). There were no difference in the proportion of patients with a median FC > 200 mg/kg (18.2% vs 17.1%; p = .767) and in the proportion of patients who changed their medical treatment (24.7% vs 23.9%; p = .713) in the first year of the pandemic compared to the prepandemic year.\n\nThe shift towards a telemedicine oriented IBD healthcare service in the first year of the pandemic significantly increased the scheduled contacts, as well as the frequency of FC testing. However, there was a significant decrease in performed surveillance colonoscopies. Between the two periods observed, the patients showed no difference in medical treatment or in disease activity.", "doi": "10.1080/00365521.2021.1993328", "pmid": "34699290", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-27T05:07:31.917Z", "modified": "2021-10-27T05:07:46.378Z"}, {"entity": "publication", "iuid": "0b8c088789ae4f52b144b57d5b341d3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b8c088789ae4f52b144b57d5b341d3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b8c088789ae4f52b144b57d5b341d3d"}}, "title": "Telemedicine as an alternative way to access abortion in Italy and characteristics of requests during the COVID-19 pandemic", "authors": [{"family": "Brandell", "given": "Karin", "initials": "K", "orcid": "0000-0003-0548-3374", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8948d3105df4faaa867b27a1fb3d4ed.json"}}, {"family": "Vanbenschoten", "given": "Hannah", "initials": "H"}, {"family": "Parachini", "given": "Mirella", "initials": "M"}, {"family": "Gomperts", "given": "Rebecca", "initials": "R"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}], "type": "journal-article", "published": "2021-10-25", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-1991", "pages": "bmjsrh-2021-201281", "issn-l": null}, "abstract": null, "doi": "10.1136/bmjsrh-2021-201281", "pmid": null, "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:32:18.606Z", "modified": "2021-10-26T18:32:18.674Z"}, {"entity": "publication", "iuid": "66ddd8c7d6ab449e9cfff0cbc669e25b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66ddd8c7d6ab449e9cfff0cbc669e25b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66ddd8c7d6ab449e9cfff0cbc669e25b"}}, "title": "Synchronization in epidemic growth and the impossibility of selective containment.", "authors": [{"family": "Budich", "given": "Jan C", "initials": "JC"}, {"family": "Bergholtz", "given": "Emil J", "initials": "EJ"}], "type": "journal article", "published": "2021-10-25", "journal": {"title": "Math Med Biol", "issn": "1477-8602", "issn-l": null}, "abstract": "Containment, aiming to prevent the epidemic stage of community-spreading altogether, and mitigation, aiming to merely 'flatten the curve' of a wide-ranged outbreak, constitute two qualitatively different approaches to combating an epidemic through non-pharmaceutical interventions. Here, we study a simple model of epidemic dynamics separating the population into two groups, namely a low-risk group and a high-risk group, for which different strategies are pursued. Due to synchronization effects, we find that maintaining a slower epidemic growth behaviour for the high-risk group is unstable against any finite coupling between the two groups. More precisely, the density of infected individuals in the two groups qualitatively evolves very similarly, apart from a small time delay and an overall scaling factor quantifying the coupling between the groups. Hence, selective containment of the epidemic in a targeted (high-risk) group is practically impossible whenever the surrounding society implements a mitigated community-spreading. We relate our general findings to the ongoing COVID-19 pandemic.", "doi": "10.1093/imammb/dqab013", "pmid": "34695187", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6409757"}], "notes": [], "created": "2021-10-26T18:28:24.487Z", "modified": "2021-10-26T18:28:24.523Z"}, {"entity": "publication", "iuid": "0f3f009975074859a7e934f2272ba059", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0f3f009975074859a7e934f2272ba059.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0f3f009975074859a7e934f2272ba059"}}, "title": "Deviant Swedes in the Global Covid-19 Media Environment", "authors": [{"family": "Irwin", "given": "Rachel E", "initials": "RE"}], "type": "journal-article", "published": "2021-10-25", "journal": {"title": "Medical Anthropology", "issn": "0145-9740", "pages": "1-15", "issn-l": null}, "abstract": null, "doi": "10.1080/01459740.2021.1988594", "pmid": null, "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:32:03.030Z", "modified": "2021-10-26T18:32:03.067Z"}, {"entity": "publication", "iuid": "2664b49079004ce3ab5f1bbf0f59e1df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2664b49079004ce3ab5f1bbf0f59e1df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2664b49079004ce3ab5f1bbf0f59e1df"}}, "title": "Consequences of the Covid-19 virus on individuals receiving homecare services in Norway. A qualitative study of nursing students' reflective notes.", "authors": [{"family": "Eide", "given": "Leslie S P", "initials": "LSP"}, {"family": "Giske", "given": "Tove", "initials": "T"}, {"family": "Kuven", "given": "Britt Moene", "initials": "BM"}, {"family": "Johansson", "given": "Linda", "initials": "L"}], "type": "journal article", "published": "2021-10-25", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "issn-l": null, "volume": "20", "issue": "1", "pages": "208"}, "abstract": "Reflective notes in nursing education can facilitate students' understanding of how individuals in need of home healthcare services experience unfamiliar situations, such as a pandemic. The aim of this study is to describe the consequences of the COVID-19 virus for individuals receiving homecare services through the eyes of nursing students.\r\n\r\nThis is a qualitative descriptive study using content analysis to examine reflection notes from 17 nursing students in their last year of academic studies while undertaking home healthcare service training.\r\n\r\nOur study shows students' reflections on the consequences of the COVID-19 virus on individuals needing home healthcare services and their families. The analysis reveals three categories that described the effect of the virus according to students' reflections: i) how social life became restricted and only includes the closest family members and home healthcare staff (declining social circle), ii) how family members take on more responsibility to care for the individual and the pronounced impact of this on the day-to-day lives of the individual's next of kin (expanding responsibility of care), and iii) actions and reactions related to preventing the spread of the virus (dealing with the invisible threat).\r\n\r\nStudents' reflection notes show that COVID-19 had major consequences, not only on the individuals receiving home healthcare services, but also on their relatives and on home healthcare staff.", "doi": "10.1186/s12912-021-00732-x", "pmid": "34689756", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12912-021-00732-x"}], "notes": [], "created": "2021-10-26T18:20:20.104Z", "modified": "2022-02-17T12:19:36.937Z"}, {"entity": "publication", "iuid": "c47d5d1ccea24687a1359fc194361747", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c47d5d1ccea24687a1359fc194361747.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c47d5d1ccea24687a1359fc194361747"}}, "title": "Factors related to preventive COVID-19 behaviors using health belief model among general population: a cross-sectional study in Iran.", "authors": [{"family": "Karimy", "given": "Mahmood", "initials": "M"}, {"family": "Bastami", "given": "Fatemeh", "initials": "F"}, {"family": "Sharifat", "given": "Robab", "initials": "R"}, {"family": "Heydarabadi", "given": "Akbar Babaei", "initials": "AB"}, {"family": "Hatamzadeh", "given": "Naser", "initials": "N"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Cheraghian", "given": "Bahman", "initials": "B"}, {"family": "Zamani-Alavijeh", "given": "Fereshteh", "initials": "F"}, {"family": "Jasemzadeh", "given": "Mehrnoosh", "initials": "M"}, {"family": "Araban", "given": "Marzieh", "initials": "M", "orcid": "0000-0001-9920-0261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/267b131c24034c33b0ddff1b97f316a5.json"}}], "type": "journal article", "published": "2021-10-24", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "21", "issue": "1", "pages": "1934", "issn-l": null}, "abstract": "Coronavirus disease (COVID-19) pandemic has become one of the biggest challenges to global health and economy. The present study aimed to explore the factors related to preventive health behaviors during the COVID-19 pandemic in Khuzestan Province, South of Iran, using the Health Belief Model (HBM).\n\nThe present cross-sectional study was conducted in the period between July 2020 and September 2020. A total of 1090 people from Khuzestan province participated in the study. The data collection method included a multistage cluster sampling method with a random selection of provincial of health centers. The questionnaire collected socio-demographic information and HBM constructs (e.g., perceived susceptibility, perceived severity, perceived benefits and barriers, cues to action, and COVID-19 preventive behaviors). Data were analyzed using ANOVA, t-test, hierarchical multiple linear regression, and SPSS version 22.\n\nThe mean age of the participants was 35.53 \u00b1 11.53, more than half of them were female (61.6%) and married (65.3). The results showed that 27% of the variance in the COVID-19 preventive behaviors was explained by HBM constructs. The regression analysis indicated that female gender (\u03b2 = 0.11), perceived benefits (\u03b2 = 0.10), perceived barriers (\u03b2 = - 0.18), external cues to action (\u03b2 = 0.25), and internal cues to action (\u03b2 = 0.12) were significantly associated with COVID-19 preventive behaviors (p < 0.05).\n\nDesigning an educational intervention on the basis of HBM might be considered as a framework for the correction of beliefs and adherence to COVID-19 behavior. Health information campaigns need to (1) emphasize the benefits of preventive behaviors including avoiding the likelihood of getting a chronic disease and complications of the disease, (2) highlight the tips and advice to overcome the barriers (3) provide cues to action by means of showing various reminders in social media (4) focusing on adoption of COVID-19-related preventive behaviors, especially among men.", "doi": "10.1186/s12889-021-11983-3", "pmid": "34689728", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11983-3"}], "notes": [], "created": "2021-10-26T18:19:52.461Z", "modified": "2021-10-26T18:20:04.121Z"}, {"entity": "publication", "iuid": "753088ac0907438a849b4b5a119ed2cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/753088ac0907438a849b4b5a119ed2cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/753088ac0907438a849b4b5a119ed2cb"}}, "title": "X-Linked TLR7 Deficiency Underlies Critical COVID-19 Pneumonia in a Male Patient with Ataxia-Telangiectasia.", "authors": [{"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Vosughimotlagh", "given": "Ahmad", "initials": "A"}, {"family": "Asano", "given": "Takaki", "initials": "T"}, {"family": "Landegren", "given": "Nils", "initials": "N"}, {"family": "Boisson", "given": "Bertrand", "initials": "B"}, {"family": "Delavari", "given": "Samaneh", "initials": "S"}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Aranda-Guill\u00e9n", "given": "Maribel", "initials": "M"}, {"family": "Wang", "given": "Yating", "initials": "Y"}, {"family": "Zuo", "given": "Fanglei", "initials": "F"}, {"family": "Sardh", "given": "Fabian", "initials": "F"}, {"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Zhang", "given": "Qian", "initials": "Q"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q", "orcid": "0000-0003-1990-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94a32366862b470eba3a15521b9be290.json"}}], "type": "journal article", "published": "2021-10-23", "journal": {"title": "J Clin Immunol", "issn": "1573-2592", "issn-l": "0271-9142"}, "abstract": "Coronavirus disease 2019 (COVID-19) exhibits a wide spectrum of clinical manifestations, ranging from asymptomatic to critical conditions. Understanding the mechanism underlying life-threatening COVID-19 is instrumental for disease prevention and treatment in individuals with a high risk.\n\nWe aimed to identify the genetic cause for critical COVID-19 pneumonia in a patient with a preexisting inborn error of immunity (IEI).\n\nSerum levels of specific antibodies against the virus and autoantibodies against type I interferons (IFNs) were measured. Whole exome sequencing was performed, and the impacts of candidate gene variants were investigated. We also evaluated 247 ataxia-telangiectasia (A-T) patients in the Iranian IEI registry.\n\nWe report a 7-year-old Iranian boy with a preexisting hyper IgM syndrome who developed critical COVID-19 pneumonia. IgM only specific COVID-19 immune response was detected but no autoantibodies against type I IFN were observed. A homozygous deleterious mutation in the ATM gene was identified, which together with his antibody deficiency, radiosensitivity, and neurological signs, established a diagnosis of A-T. Among the 247 A-T patients evaluated, 36 had SARS-CoV-2 infection, but all had mild symptoms or were asymptomatic except the index patient. A hemizygous deleterious mutation in the TLR7 gene was subsequently identified in the patient.\n\nWe report a unique IEI patient with combined ATM and TLR7 deficiencies. The two genetic defects underlie A-T and critical COVID-19 in this patient, respectively.", "doi": "10.1007/s10875-021-01151-y", "pmid": "34686943", "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10875-021-01151-y"}, {"db": "pmc", "key": "PMC8536475"}], "notes": [], "created": "2021-10-26T18:18:29.681Z", "modified": "2021-11-18T15:08:59.029Z"}, {"entity": "publication", "iuid": "13be130c39184985887399e1f4a8c94e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13be130c39184985887399e1f4a8c94e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13be130c39184985887399e1f4a8c94e"}}, "title": "Potential therapeutic effect of oxygen-ozone in controlling of COVID-19 disease.", "authors": [{"family": "Yousefi", "given": "Bahman", "initials": "B"}, {"family": "Banihashemian", "given": "Seyedeh Zahra", "initials": "SZ"}, {"family": "Feyzabadi", "given": "Zahra Khatibiyan", "initials": "ZK"}, {"family": "Hasanpour", "given": "Sahar", "initials": "S"}, {"family": "Kokhaei", "given": "Parviz", "initials": "P"}, {"family": "Abdolshahi", "given": "Anna", "initials": "A"}, {"family": "Emadi", "given": "Alireza", "initials": "A"}, {"family": "Eslami", "given": "Majid", "initials": "M"}], "type": "journal article", "published": "2021-10-23", "journal": {"title": "Med Gas Res", "issn": "2045-9912", "volume": "12", "issue": "2", "pages": "33-40", "issn-l": null}, "abstract": "Atmospheric ozone is produced when nitrogen oxides react with volatile organic compounds. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome contains a unique N-terminal fragment in the Spike protein, which allows it to bind to air pollutants in the environment. 'Our approach in this review is to study ozone and its effect on the SARS-CoV-2 virus and patients with coronavirus disease 2019 (COVID-19). Article data were collected from PubMed, Scopus, and Google Scholar databases. Ozone therapy has antiviral properties, improves blood flow, facilitates the transfer of oxygen in hypoxemic tissues, and reduces blood coagulation phenomena in COVID-19 patients. Ozone has immunomodulatory effects by modulating cytokines (reduction of interleukin-1, interleukin-6, tumor necrosis factor-\u03b1, and interleukin-10), induction of interferon-\u03b3, anti-inflammatory properties by modulating NOD-, LRR- and pyrin domain-containing protein 3, inhibition of cytokine storm (blocking nuclear factor-\u03baB and stimulating nuclear factor erythroid 2-related factor 2 pathway), stimulates cellular/humoral immunity/phagocytic function and blocks angiotensin-converting enzyme 2. In direct oxygen-ozone injection, oxygen reacts with several biological molecules such as thiol groups in albumin to form ozonoids. Intravenous injection of ozonated saline significantly increases the length of time a person can remain hypoxic. The rectal ozone protocol is rectal ozone insufflation, resulting in clinical improvement in oxygen saturation and biochemical improvement (fibrinogen, D-dimer, urea, ferritin, LDH, interleukin-6, and C-reactive protein). In general, many studies have shown the positive effect of ozone therapy as a complementary therapy in the recovery of COVID-19 patients. All the findings indicate that systemic ozone therapy is nontoxic and has no side effects in these patients.", "doi": "10.4103/2045-9912.325989", "pmid": "34677149", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "MedGasRes_2022_12_2_33_325989"}], "notes": [], "created": "2021-10-26T18:13:10.520Z", "modified": "2021-10-26T18:13:10.562Z"}, {"entity": "publication", "iuid": "309ad45ec547436298caa7a3df2df00d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/309ad45ec547436298caa7a3df2df00d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/309ad45ec547436298caa7a3df2df00d"}}, "title": "Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19.", "authors": [{"family": "Schulthei\u00df", "given": "Christoph", "initials": "C"}, {"family": "Paschold", "given": "Lisa", "initials": "L"}, {"family": "Willscher", "given": "Edith", "initials": "E"}, {"family": "Simnica", "given": "Donjete", "initials": "D"}, {"family": "W\u00f6stemeier", "given": "Anna", "initials": "A"}, {"family": "Muscate", "given": "Franziska", "initials": "F"}, {"family": "Wass", "given": "Maxi", "initials": "M"}, {"family": "Eisenmann", "given": "Stephan", "initials": "S"}, {"family": "Dutzmann", "given": "Jochen", "initials": "J"}, {"family": "Key\u00dfer", "given": "Gernot", "initials": "G"}, {"family": "Gagliani", "given": "Nicola", "initials": "N"}, {"family": "Binder", "given": "Mascha", "initials": "M"}], "type": "journal article", "published": "2021-10-23", "journal": {"title": "iScience", "issn": "2589-0042", "pages": "103325", "issn-l": "2589-0042"}, "abstract": "In parasite and viral infections, aberrant B cell responses can suppress germinal center reactions thereby blunting long-lived memory and may provoke immunopathology including autoimmunity. Using COVID-19 as model, we set out to identify serological, cellular and transcriptomic imprints of pathological responses linked to autoreactive B cells at single-cell resolution. We show that excessive plasmablast expansions are prognostically adverse, correlate with auto-antibody production, but do not hinder the formation of neutralizing antibodies. While plasmablasts followed IL-4 and BAFF driven developmental trajectories, were polyclonal and not enriched in autoreactive B cells, we identified two memory populations (CD80+/ISG15+ and CD11c+/SOX5+/T-bet+/-) with immunogenetic and transcriptional signs of autoreactivity that may be the cellular source of auto-antibodies in COVID-19 and that may persist beyond recovery. Immunomodulatory interventions discouraging such adverse responses may be useful in selected patients to shift the balance from autoreactivity towards long-term memory.", "doi": "10.1016/j.isci.2021.103325", "pmid": "34723157", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(21)01294-3"}, {"db": "pmc", "key": "PMC8536484"}], "notes": [], "created": "2021-11-02T15:32:21.332Z", "modified": "2021-11-02T15:32:55.847Z"}, {"entity": "publication", "iuid": "38187affa925475985a1875afa76de7b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38187affa925475985a1875afa76de7b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38187affa925475985a1875afa76de7b"}}, "title": "Family Function and Child Adjustment Difficulties in the COVID-19 Pandemic: An International Study.", "authors": [{"family": "Foley", "given": "Sarah", "initials": "S"}, {"family": "Badinlou", "given": "Farzaneh", "initials": "F"}, {"family": "Brocki", "given": "Karin C", "initials": "KC"}, {"family": "Frick", "given": "Matilda A", "initials": "MA"}, {"family": "Ronchi", "given": "Luca", "initials": "L", "orcid": "0000-0001-7723-9376", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1e89c62c76f443288c1df82f370cdf4.json"}}, {"family": "Hughes", "given": "Claire", "initials": "C"}], "type": "journal article", "published": "2021-10-23", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "21", "issn-l": null}, "abstract": "To estimate specific proximal and distal effects of COVID-19-related restrictions on families on children's adjustment problems, we conducted a six-site international study. In total, 2516 parents from Australia, China, Italy, Sweden, the United Kingdom, and the United States of America living with a young child (M = 5.77, ageSD = 1.10, range = 3 to 8 years, 47.9% female) completed an online survey between April and July 2020. The survey included the Strengths and Difficulties Questionnaire and family risk factors (parent distress, parent-child conflict, couple conflict, and household chaos) as well as a scale to index COVID-19-related family disruption. Our analyses also included public data on the stringency of national restrictions. Across the six sites, parental responses indicated elevated levels of hyperactivity, conduct, and emotion problems in children from families characterized by heightened levels of parent distress, parent-child conflict, and household chaos. In contrast, increased peer problems were more strongly related to COVID-19-related social disruption and stringency measures. Mediation models demonstrated that associations between COVID-19 social disruption and child difficulties could be explained by parental distress. Taken together, these results suggest that although the experience of the pandemic differed across countries, associations between COVID-19-related family experiences and child adjustment difficulties were similar in their nature and magnitude across six different contexts. Programs to support family resilience could help buffer the impact of the pandemic for two generations.", "doi": "10.3390/ijerph182111136", "pmid": "34769654", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph182111136"}, {"db": "pmc", "key": "PMC8582895"}], "notes": [], "created": "2021-11-26T15:10:11.167Z", "modified": "2021-11-26T15:10:11.226Z"}, {"entity": "publication", "iuid": "38d1fc5ab22a4d00aedc4f1700140bdf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38d1fc5ab22a4d00aedc4f1700140bdf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38d1fc5ab22a4d00aedc4f1700140bdf"}}, "title": "Use of Quantitative Dried Blood Spots to Evaluate the Post-Vaccination Level of Neutralizing Antibodies against SARS-CoV-2.", "authors": [{"family": "Marchand", "given": "Alexandre", "initials": "A", "orcid": "0000-0002-2670-6939", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19b0f52f01ef473d91392b151603c1c3.json"}}, {"family": "Roulland", "given": "Ingrid", "initials": "I"}, {"family": "Semence", "given": "Florian", "initials": "F", "orcid": "0000-0002-2313-9246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2fef84471334fb8b8688905d5426487.json"}}, {"family": "Beck", "given": "Olof", "initials": "O"}, {"family": "Ericsson", "given": "Magnus", "initials": "M", "orcid": "0000-0002-4123-3084", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72e1b083138945508edb8121d47826e3.json"}}], "type": "journal article", "published": "2021-10-22", "journal": {"title": "Life (Basel)", "issn": "2075-1729", "volume": "11", "issue": "11", "pages": "1125", "issn-l": null}, "abstract": "To combat the COVID-19 pandemic, vaccines against SARS-CoV-2 are now given to protect populations worldwide. The level of neutralizing antibodies following the vaccination will evolve with time and vary between individuals. Immunoassays quantifying immunoglobulins against the viral spike (S) protein in serum/plasma have been developed, but the need for venous blood samples could limit the frequency and scale of control in populations. The use of a quantitative dried blood spot (DBS) that can be self-collected would simplify this monitoring. The objective of this study was to determine whether a quantitative DBS device (Capitainer qDBS 10 \u00b5L) could be used in combination with an Elecsys anti-SARS-CoV-2 S immunoassay from Roche to follow the development and persistence of anti-S antibodies. This objective was carried out through two clinical studies. The first study investigated 14 volunteers who received two doses of the Comirnaty (Pfizer) vaccine. The levels of anti-S antibodies and the progression over time post-vaccination were studied for three months. The level of produced antibodies varied between subjects, but a similar trend was observed. The anti-S antibodies were highly stimulated by the second dose (\u00d7100) and peaked two weeks later. The antibody levels subsequently decreased and three months later were down to 65%. DBS proved to be sufficiently sensitive for use in evaluating the immune status against SARS-CoV-2 over a prolonged time. The second cohort was composed of 200 random patients from a clinical chemistry department in Stockholm. In this cohort, we had no information on previous COVID-19 infections or vaccination. Nevertheless, 87% of the subjects had anti-S immunoglobulins over 0.8 U/mL, and the bias between plasma and DBS proved to be variable, as was also seen in the first vaccination study.", "doi": "10.3390/life11111125", "pmid": "34833001", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8620034"}, {"db": "pii", "key": "life11111125"}], "notes": [], "created": "2021-12-18T18:15:01.656Z", "modified": "2023-06-19T14:20:04.060Z"}, {"entity": "publication", "iuid": "82b7b8a2c81044dd954af8d86a918c8d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82b7b8a2c81044dd954af8d86a918c8d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82b7b8a2c81044dd954af8d86a918c8d"}}, "title": "SARS-CoV-2 specific B- and T-cell immunity in a population-based study of young Swedish adults.", "authors": [{"family": "Bj\u00f6rkander", "given": "Sophia", "initials": "S"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Zuo", "given": "Fanglei", "initials": "F"}, {"family": "Ekstr\u00f6m", "given": "Sandra", "initials": "S"}, {"family": "Wang", "given": "Yating", "initials": "Y"}, {"family": "Wan", "given": "Hui", "initials": "H"}, {"family": "Sherina", "given": "Natalia", "initials": "N"}, {"family": "Schoutens", "given": "Lisanne", "initials": "L"}, {"family": "Andr\u00e9ll", "given": "Juni", "initials": "J"}, {"family": "Andersson", "given": "Niklas", "initials": "N"}, {"family": "Georgelis", "given": "Antonios", "initials": "A"}, {"family": "Bergstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Kull", "given": "Inger", "initials": "I"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}, {"family": "BAMSE COVID-19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-10-22", "journal": {"title": "J Allergy Clin Immunol", "issn": "1097-6825", "issn-l": "0091-6749"}, "abstract": "Young adults are now considered major spreaders of COVID-19 disease. Although most young individuals suffer from mild to moderate disease, there are concerns of long-term adverse health effects. The impact of COVID-19 disease and to which extent population-level immunity against SARS-CoV-2 exist in young adults remain unclear.\n\nTo conduct a population-based study on humoral and cellular immunity to SARS-CoV-2 and explore COVID-19 disease characteristics in young adults.\n\nWe invited participants from the Swedish BAMSE birth cohort (age 24-27 years) to take part in a COVID-19 follow-up. From 980 participants (October 2020-June 2021), we here present data on SARS-CoV-2 RBD-specific IgM, IgA and IgG titres measured by ELISA and on symptoms and epidemiological factors associated with seropositivity. Further, SARS-CoV-2-specific memory B- and T-cell responses were detected for a subpopulation (n=108) by ELISpot and Fluorospot.\n\n28.4% of subjects were seropositive of which 18.4% were IgM single positive. One in seven seropositive subjects were asymptomatic. Seropositivity associated with use of public transport, but not with sex, asthma, rhinitis, IgE-sensitization, smoking or BMI. In a subset of representative samples, 20.7% and 35.0% had detectable SARS-CoV-2 specific B- and T-cell responses, respectively. B- and T-cell memory responses were clearly associated with seropositivity, but T-cell responses were also detected in 17.2% of seronegative subjects.\n\nAssessment of IgM and T-cell responses may improve population-based estimations of SARS-CoV-2 infection. The pronounced surge of both symptomatic and asymptomatic infections among young adults should imply a continuation of the large-scale vaccination campaign.", "doi": "10.1016/j.jaci.2021.10.014", "pmid": "34695490", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Funder: VR": null, "Funder: H2020": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pii", "key": "S0091-6749(21)01626-2"}], "notes": [], "created": "2021-10-26T18:21:08.827Z", "modified": "2021-10-26T18:23:13.339Z"}, {"entity": "publication", "iuid": "c5eee811036f4f19b853bdb01f8ecbbc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5eee811036f4f19b853bdb01f8ecbbc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5eee811036f4f19b853bdb01f8ecbbc"}}, "title": "Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue.", "authors": [{"family": "Niessl", "given": "Julia", "initials": "J", "orcid": "0000-0001-8852-1924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70aba42c7f0b400eba1a226ee193d9fd.json"}}, {"family": "Sekine", "given": "Takuya", "initials": "T", "orcid": "0000-0001-7649-0593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a234e0d77c145aa8d23b89fde1c5883.json"}}, {"family": "Lange", "given": "Joshua", "initials": "J", "orcid": "0000-0001-6452-0695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1cca3794b2844599b618aa215421d61b.json"}}, {"family": "Konya", "given": "Viktoria", "initials": "V"}, {"family": "Forkel", "given": "Marianne", "initials": "M"}, {"family": "Maric", "given": "Jovana", "initials": "J"}, {"family": "Rao", "given": "Anna", "initials": "A"}, {"family": "Mazzurana", "given": "Luca", "initials": "L"}, {"family": "Kokkinou", "given": "Efthymia", "initials": "E"}, {"family": "Weigel", "given": "Whitney", "initials": "W"}, {"family": "Llewellyn-Lacey", "given": "Sian", "initials": "S", "orcid": "0000-0002-4703-0413", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d3831e832f6b490d9b24d89170e66eaa.json"}}, {"family": "Hodcroft", "given": "Emma B", "initials": "EB", "orcid": "0000-0002-0078-2212", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/563993c9fb68466c8867ca7600733548.json"}}, {"family": "Karlsson", "given": "Annika C", "initials": "AC", "orcid": "0000-0002-2028-8393", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9abf28110888427497db1e4abf6ff71d.json"}}, {"family": "Fehrm", "given": "Johan", "initials": "J", "orcid": "0000-0002-4304-3700", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/948413806ff24d02b4f0016c8e1af6bf.json"}}, {"family": "Sundman", "given": "Joar", "initials": "J", "orcid": "0000-0003-4475-603X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5092a6807ecd460d83fd07790267fac6.json"}}, {"family": "Price", "given": "David A", "initials": "DA", "orcid": "0000-0001-9416-2737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/734b7fd55fca47f8b00d1281331ef39a.json"}}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J", "orcid": "0000-0002-1119-0976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41c258d321084e909f0c9a6ff8693533.json"}}, {"family": "Friberg", "given": "Danielle", "initials": "D", "orcid": "0000-0001-8327-1292", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7003e0514ab84574b19ac36dff3f8825.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}], "type": "journal article", "published": "2021-10-22", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "issn-l": "2470-9468", "volume": "6", "issue": "64", "pages": "eabk0894"}, "abstract": "Cross-reactive CD4+ T cells that recognize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more commonly detected in the peripheral blood of unexposed individuals compared with SARS-CoV-2\u2013reactive CD8+ T cells. However, large numbers of memory CD8+ T cells reside in tissues, feasibly harboring localized SARS-CoV-2\u2013specific immune responses. To test this idea, we performed a comprehensive functional and phenotypic analysis of virus-specific T cells in tonsils, a major lymphoid tissue site in the upper respiratory tract, and matched peripheral blood samples obtained from children and adults before the emergence of COVID-19 (coronavirus disease 2019). We found that SARS-CoV-2\u2013specific memory CD4+ T cells could be found at similar frequencies in the tonsils and peripheral blood in unexposed individuals, whereas functional SARS-CoV-2\u2013specific memory CD8+ T cells were almost only detectable in the tonsils. Tonsillar SARS-CoV-2\u2013specific memory CD8+ T cells displayed a follicular homing and tissue-resident memory phenotype, similar to tonsillar Epstein-Barr virus\u2013specific memory CD8+ T cells, but were functionally less potent than other virus-specific memory CD8+ T cell responses. The presence of preexisting tissue-resident memory CD8+ T cells in unexposed individuals could potentially enable rapid sentinel immune responses against SARS-CoV-2.", "doi": "10.1126/sciimmunol.abk0894", "pmid": "34519539", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: VR": null}, "xrefs": [], "notes": [], "created": "2021-09-20T06:25:17.561Z", "modified": "2023-06-19T14:47:48.944Z"}, {"entity": "publication", "iuid": "691b17ed7dd44d05923a3ddeca351561", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/691b17ed7dd44d05923a3ddeca351561.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/691b17ed7dd44d05923a3ddeca351561"}}, "title": "Epidemic versus economic performances of the COVID-19 lockdown in Japan: A Mobility Data Analysis.", "authors": [{"family": "Zhang", "given": "Haoran", "initials": "H"}, {"family": "Li", "given": "Peiran", "initials": "P"}, {"family": "Zhang", "given": "Zhiwen", "initials": "Z"}, {"family": "Li", "given": "Wenjing", "initials": "W"}, {"family": "Chen", "given": "Jinyu", "initials": "J"}, {"family": "Song", "given": "Xuan", "initials": "X"}, {"family": "Shibasaki", "given": "Ryosuke", "initials": "R"}, {"family": "Yan", "given": "Jinyue", "initials": "J"}], "type": "journal article", "published": "2021-10-22", "journal": {"title": "Cities", "issn": "0264-2751", "issn-l": null, "volume": null, "issue": null, "pages": "103502"}, "abstract": "Lockdown measures have been a \"panacea\" for pandemic control but also a violent \"poison\" for economies. Lockdown policies strongly restrict human mobility but mobility reduce does harm to economics. Governments meet a thorny problem in balancing the pros and cons of lockdown policies, but lack comprehensive and quantified guides. Based on millions of financial transaction records, and billions of mobility data, we tracked spatio-temporal business networks and human daily mobility, then proposed a high-resolution two-sided framework to assess the epidemiological performance and economic damage of different lockdown policies. We found that the pandemic duration under the strictest lockdown is less about two months than that under the lightest lockdown, which makes the strictest lockdown characterize both epidemiologically and economically efficient. Moreover, based on the two-sided model, we explored the spatial lockdown strategy. We argue that cutting off intercity commuting is significant in both epidemiological and economical aspects, and finally helped governments figure out the Pareto optimal solution set of lockdown strategy.", "doi": "10.1016/j.cities.2021.103502", "pmid": "34703071", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0264-2751(21)00401-7"}, {"db": "pmc", "key": "PMC8531026"}], "notes": [], "created": "2021-11-01T19:41:11.603Z", "modified": "2021-11-01T19:41:41.272Z"}, {"entity": "publication", "iuid": "dacbc120d6864970a1e0bad1a9fb510e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dacbc120d6864970a1e0bad1a9fb510e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dacbc120d6864970a1e0bad1a9fb510e"}}, "title": "Clozapine treatment and risk of severe COVID-19 infection.", "authors": [{"family": "Ohlis", "given": "Anna", "initials": "A", "orcid": "0000-0001-9046-5773", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59faf1045fa242d28c4044315d0181d2.json"}}, {"family": "S\u00f6rberg Wallin", "given": "Alma", "initials": "A", "orcid": "0000-0002-8804-095X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bdaa3ba8e9c149a6b4c05d924f31d0e5.json"}}, {"family": "Sarafis", "given": "Anna", "initials": "A"}, {"family": "Sj\u00f6qvist", "given": "Hugo", "initials": "H"}, {"family": "MacCabe", "given": "James H", "initials": "JH", "orcid": "0000-0002-6754-1018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10525437e48b4917bcea4011f1db2d66.json"}}, {"family": "Ahlen", "given": "Johan", "initials": "J", "orcid": "0000-0003-1415-2200", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0bb3ddc3a2e0432585cf06c038554088.json"}}, {"family": "Dalman", "given": "Christina", "initials": "C"}], "type": "journal article", "published": "2021-10-22", "journal": {"title": "Acta Psychiatr Scand", "issn": "1600-0447", "issn-l": null}, "abstract": "To investigate whether patients with clozapine treatment are at an increased risk of a more severe COVID-19 infection as compared with patients on other antipsychotic drugs.\n\nIn this register-based cohort study, all residents (age 18 or older) in the Stockholm Region with a psychotic disorder diagnosis and antipsychotic treatment were included (N = 8 233) and followed from March 1, 2020 to January 14, 2021. The exposure was defined as clozapine treatment and the outcome measures (indicating a more severe COVID-19 infection) were: inpatient care, care within intensive care unit or death due to COVID-19 infection. Differences in outcome rates between exposed (n = 966) and unexposed (other antipsychotics; n = 7 267) were examined using Cox proportional hazards models and expressed as hazard ratios (HR) with 95% confidence intervals (CI).\n\nNo statistically significant differences in outcome rates were found between the two groups of patients after adjusting for age, sex, and residence in retirement homes. The adjusted HR for the exposed compared to the unexposed was 0.96 (95% CI: 0.54, 1.70) for inpatient care; 1.69 (0.48, 5.93) for care in intensive care unit (ICU); and 0.86 (0.26, 2.80) for death. Regarding inpatient care, additional adjusting for country of birth, living in socioeconomically vulnerable areas, number of care visits during the previous year, and comorbid medical illnesses did not alter the results.\n\nOur results may add support to the present guidelines, recommending sustained clozapine treatment during the current COVID-19 pandemic with careful monitoring and readiness to alter drug doses as needed.", "doi": "10.1111/acps.13379", "pmid": "34676888", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:12:37.225Z", "modified": "2021-10-26T18:12:50.320Z"}, {"entity": "publication", "iuid": "c298ed13cf994b5d98401e37cd050838", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c298ed13cf994b5d98401e37cd050838.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c298ed13cf994b5d98401e37cd050838"}}, "title": "Recurrent sick leave after COVID-19: investigating the first wave of the pandemic in a comprehensive Swedish registry-based study.", "authors": [{"family": "Palstam", "given": "Annie", "initials": "A"}, {"family": "Westerlind", "given": "Emma", "initials": "E"}, {"family": "Sunnerhagen", "given": "Katharina S", "initials": "KS"}, {"family": "Persson", "given": "Hanna C", "initials": "HC"}], "type": "journal article", "published": "2021-10-21", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "1914"}, "abstract": "Sick-leave due to COVID-19 vary in length and might lead to re-current episodes. The aim was to investigate recurrent sick leave due to COVID-19 during the first wave.\r\n\r\nThis is a registry-based cohort study. The study comprises all people with sickness benefit due to COVID-19 in Sweden in March 1-August 31, 2020. Data from the Swedish Social Insurance Agency, the Swedish National Board of Health and Welfare, and Statistics Sweden were merged.\r\n\r\nWithin the follow-up period of 4 months, 11,955 people were subject to sickness benefit due to COVID-19, whereof 242 people (2.0%) took recurrent sick leave due to COVID-19, and of those 136 (56.2%) remained on sick leave at the end of follow-up. People with recurrent sick leave were older, more often women, and more likely to have been on sick leave prior to the COVID-19 pandemic.\r\n\r\nA group of people presented with recurrent sick leave due to COVID-19. For half of them, the second sick leave lasted throughout the follow-up. People with recurrent sick leave differ in several aspects from those with shorter sick leave. To capture long-term sick-leave patterns due to COVID-19, a longer period of follow-up is needed.", "doi": "10.1186/s12889-021-11918-y", "pmid": "34674673", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11918-y"}], "notes": [], "created": "2021-10-26T18:11:12.252Z", "modified": "2022-02-17T12:20:09.405Z"}, {"entity": "publication", "iuid": "258c795b973e4ab0a2adf939ddf7850b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/258c795b973e4ab0a2adf939ddf7850b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/258c795b973e4ab0a2adf939ddf7850b"}}, "title": "Implementation Science for Managers and Healthcare Organizations Responding to Emergencies", "authors": [{"family": "\u00d8vretveit", "given": "John", "initials": "J", "orcid": "0000-0001-9668-0175", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82d14033e7314a27a9ac093d99058bc8.json"}}, {"family": "Ohrling", "given": "Mikael", "initials": "M"}], "type": "journal-article", "published": "2021-10-21", "journal": {"title": "Glob Implement Res Appl", "issn": "2662-9275", "issn-l": null}, "abstract": null, "doi": "10.1007/s43477-021-00025-0", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:34:02.123Z", "modified": "2021-10-26T18:34:02.202Z"}, {"entity": "publication", "iuid": "6e938e1c59d2428bb1f45af94644ba6c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e938e1c59d2428bb1f45af94644ba6c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e938e1c59d2428bb1f45af94644ba6c"}}, "title": "Immunogenicity and safety of AZD1222 (ChAdOx1 nCoV-19) against SARS-CoV-2 in Japan: A double-blind, randomized controlled phase 1/2 trial.", "authors": [{"family": "Asano", "given": "Michiko", "initials": "M"}, {"family": "Okada", "given": "Hiroshi", "initials": "H"}, {"family": "Itoh", "given": "Yohji", "initials": "Y"}, {"family": "Hirata", "given": "Hajime", "initials": "H"}, {"family": "Ishikawa", "given": "Kensuke", "initials": "K"}, {"family": "Yoshida", "given": "Erika", "initials": "E"}, {"family": "Matsui", "given": "Akiko", "initials": "A"}, {"family": "Kelly", "given": "Elizabeth J", "initials": "EJ"}, {"family": "Shoemaker", "given": "Kathryn", "initials": "K"}, {"family": "Olsson", "given": "Urban", "initials": "U"}, {"family": "Vekemans", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2021-10-21", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712"}, "abstract": "Immunogenicity and safety of the AZD1222 (ChAdOx1 nCoV-19) vaccine was evaluated in Japanese adults in an ongoing phase 1/2, randomized, double-blind, parallel-group, placebo-controlled, multicenter trial (NCT04568031).\n\nAdults (N=256; age \u226518 years) seronegative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were stratified by age into 18-55- (n=128), 56-69- (n=86), and \u226570-year-old cohorts (n=42), then randomized 3:1 to receive AZD1222 or placebo (2 intramuscular injections 4 weeks apart). Immunogenicity and safety were coprimary endpoints. Data collected up to Day 57 are reported.\n\nPositive seroresponses to SARS-CoV-2 spike and receptor-binding domain antigens were seen in all 174 participants who received 2 doses of AZD1222. Neutralizing antibody seroresponses were seen in 67.5%, 60.3%, and 50.0% of participants receiving AZD1222 aged 18-55, 56-69, and \u226570 years, respectively. Solicited adverse events (AEs) were typically mild/moderate in severity and included injection site pain and tenderness, malaise, fatigue, muscle pains, and headache. Common unsolicited AEs included injection site pain and tenderness, fatigue, and elevated body temperature. No vaccine-related serious AEs or deaths were reported.\n\nAZD1222 elicited a strong humoral immune response against SARS-CoV-2 and was well tolerated in Japanese participants, including elderly participants.", "doi": "10.1016/j.ijid.2021.10.030", "pmid": "34688944", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)00818-3"}, {"db": "ClinicalTrials.gov", "key": "NCT04568031"}], "notes": [], "created": "2021-10-26T18:19:19.803Z", "modified": "2021-10-26T18:19:19.816Z"}, {"entity": "publication", "iuid": "09e3fbede2484edabd3786ae8bd64fd5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/09e3fbede2484edabd3786ae8bd64fd5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/09e3fbede2484edabd3786ae8bd64fd5"}}, "title": "Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia: The COVID STEROID 2 Randomized Trial.", "authors": [{"family": "COVID STEROID 2 Trial Group", "given": "", "initials": ""}, {"family": "Munch", "given": "Marie W", "initials": "MW"}, {"family": "Myatra", "given": "Sheila N", "initials": "SN"}, {"family": "Vijayaraghavan", "given": "Bharath Kumar Tirupakuzhi", "initials": "BKT"}, {"family": "Saseedharan", "given": "Sanjith", "initials": "S"}, {"family": "Benfield", "given": "Thomas", "initials": "T"}, {"family": "Wahlin", "given": "Rebecka R", "initials": "RR"}, {"family": "Rasmussen", "given": "Bodil S", "initials": "BS"}, {"family": "Andreasen", "given": "Anne Sofie", "initials": "AS"}, {"family": "Poulsen", "given": "Lone M", "initials": "LM"}, {"family": "Cioccari", "given": "Luca", "initials": "L"}, {"family": "Khan", "given": "Mohd S", "initials": "MS"}, {"family": "Kapadia", "given": "Farhad", "initials": "F"}, {"family": "Divatia", "given": "Jigeeshu V", "initials": "JV"}, {"family": "Br\u00f8chner", "given": "Anne C", "initials": "AC"}, {"family": "Bestle", "given": "Morten H", "initials": "MH"}, {"family": "Helleberg", "given": "Marie", "initials": "M"}, {"family": "Michelsen", "given": "Jens", "initials": "J"}, {"family": "Padmanaban", "given": "Ajay", "initials": "A"}, {"family": "Bose", "given": "Neeta", "initials": "N"}, {"family": "M\u00f8ller", "given": "Anders", "initials": "A"}, {"family": "Borawake", "given": "Kapil", "initials": "K"}, {"family": "Kristiansen", "given": "Klaus T", "initials": "KT"}, {"family": "Shukla", "given": "Urvi", "initials": "U"}, {"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Dixit", "given": "Subhal", "initials": "S"}, {"family": "Ulrik", "given": "Charlotte S", "initials": "CS"}, {"family": "Amin", "given": "Pravin R", "initials": "PR"}, {"family": "Chawla", "given": "Rajesh", "initials": "R"}, {"family": "Wamberg", "given": "Christian A", "initials": "CA"}, {"family": "Shah", "given": "Mehul S", "initials": "MS"}, {"family": "Darfelt", "given": "Iben S", "initials": "IS"}, {"family": "J\u00f8rgensen", "given": "Vibeke L", "initials": "VL"}, {"family": "Smitt", "given": "Margit", "initials": "M"}, {"family": "Granholm", "given": "Anders", "initials": "A"}, {"family": "Kj\u00e6r", "given": "Maj-Brit N", "initials": "MN"}, {"family": "M\u00f8ller", "given": "Morten H", "initials": "MH"}, {"family": "Meyhoff", "given": "Tine S", "initials": "TS"}, {"family": "Vesterlund", "given": "Gitte K", "initials": "GK"}, {"family": "Hammond", "given": "Naomi E", "initials": "NE"}, {"family": "Micallef", "given": "Sharon", "initials": "S"}, {"family": "Bassi", "given": "Abhinav", "initials": "A"}, {"family": "John", "given": "Oommen", "initials": "O"}, {"family": "Jha", "given": "Anubhuti", "initials": "A"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Jakob", "given": "Stephan M", "initials": "SM"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Lange", "given": "Theis", "initials": "T"}, {"family": "Kadam", "given": "Vaijayanti", "initials": "V"}, {"family": "Marcussen", "given": "Klaus V", "initials": "KV"}, {"family": "Hollenberg", "given": "Jacob", "initials": "J"}, {"family": "Hedman", "given": "Anders", "initials": "A"}, {"family": "Nielsen", "given": "Henrik", "initials": "H"}, {"family": "Schj\u00f8rring", "given": "Olav L", "initials": "OL"}, {"family": "Jensen", "given": "Marie Q", "initials": "MQ"}, {"family": "Leistner", "given": "Jens W", "initials": "JW"}, {"family": "Jonassen", "given": "Trine B", "initials": "TB"}, {"family": "Kristensen", "given": "Camilla M", "initials": "CM"}, {"family": "Clapp", "given": "Esben C", "initials": "EC"}, {"family": "Hjorts\u00f8", "given": "Carl J S", "initials": "CJS"}, {"family": "Jensen", "given": "Thomas S", "initials": "TS"}, {"family": "Halstad", "given": "Liv S", "initials": "LS"}, {"family": "Bak", "given": "Emilie R B", "initials": "ERB"}, {"family": "Zaabalawi", "given": "Reem", "initials": "R"}, {"family": "Metcalf-Clausen", "given": "Matias", "initials": "M"}, {"family": "Abdi", "given": "Suhayb", "initials": "S"}, {"family": "Hatley", "given": "Emma V", "initials": "EV"}, {"family": "Aksnes", "given": "Tobias S", "initials": "TS"}, {"family": "Gleipner-Andersen", "given": "Emil", "initials": "E"}, {"family": "Alarc\u00f3n", "given": "Arif F", "initials": "AF"}, {"family": "Yamin", "given": "Gabriel", "initials": "G"}, {"family": "Heymowski", "given": "Adam", "initials": "A"}, {"family": "Berggren", "given": "Anton", "initials": "A"}, {"family": "La Cour", "given": "Kirstine", "initials": "K"}, {"family": "Weihe", "given": "Sarah", "initials": "S"}, {"family": "Pind", "given": "Alison H", "initials": "AH"}, {"family": "Engstr\u00f8m", "given": "Janus", "initials": "J"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Venkatesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Perner", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-10-21", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484"}, "abstract": "A daily dose with 6 mg of dexamethasone is recommended for up to 10 days in patients with severe and critical COVID-19, but a higher dose may benefit those with more severe disease.\n\nTo assess the effects of 12 mg/d vs 6 mg/d of dexamethasone in patients with COVID-19 and severe hypoxemia.\n\nA multicenter, randomized clinical trial was conducted between August 2020 and May 2021 at 26 hospitals in Europe and India and included 1000 adults with confirmed COVID-19 requiring at least 10 L/min of oxygen or mechanical ventilation. End of 90-day follow-up was on August 19, 2021.\n\nPatients were randomized 1:1 to 12 mg/d of intravenous dexamethasone (n = 503) or 6 mg/d of intravenous dexamethasone (n = 497) for up to 10 days.\n\nThe primary outcome was the number of days alive without life support (invasive mechanical ventilation, circulatory support, or kidney replacement therapy) at 28 days and was adjusted for stratification variables. Of the 8 prespecified secondary outcomes, 5 are included in this analysis (the number of days alive without life support at 90 days, the number of days alive out of the hospital at 90 days, mortality at 28 days and at 90 days, and \u22651 serious adverse reactions at 28 days).\n\nOf the 1000 randomized patients, 982 were included (median age, 65 [IQR, 55-73] years; 305 [31%] women) and primary outcome data were available for 971 (491 in the 12 mg of dexamethasone group and 480 in the 6 mg of dexamethasone group). The median number of days alive without life support was 22.0 days (IQR, 6.0-28.0 days) in the 12 mg of dexamethasone group and 20.5 days (IQR, 4.0-28.0 days) in the 6 mg of dexamethasone group (adjusted mean difference, 1.3 days [95% CI, 0-2.6 days]; P = .07). Mortality at 28 days was 27.1% in the 12 mg of dexamethasone group vs 32.3% in the 6 mg of dexamethasone group (adjusted relative risk, 0.86 [99% CI, 0.68-1.08]). Mortality at 90 days was 32.0% in the 12 mg of dexamethasone group vs 37.7% in the 6 mg of dexamethasone group (adjusted relative risk, 0.87 [99% CI, 0.70-1.07]). Serious adverse reactions, including septic shock and invasive fungal infections, occurred in 11.3% in the 12 mg of dexamethasone group vs 13.4% in the 6 mg of dexamethasone group (adjusted relative risk, 0.83 [99% CI, 0.54-1.29]).\n\nAmong patients with COVID-19 and severe hypoxemia, 12 mg/d of dexamethasone compared with 6 mg/d of dexamethasone did not result in statistically significantly more days alive without life support at 28 days. However, the trial may have been underpowered to identify a significant difference.\n\nClinicalTrials.gov Identifier: NCT04509973 and ctri.nic.in Identifier: CTRI/2020/10/028731.", "doi": "10.1001/jama.2021.18295", "pmid": "34673895", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "2785529"}, {"db": "ClinicalTrials.gov", "key": "NCT04509973"}], "notes": [], "created": "2021-10-26T18:09:59.402Z", "modified": "2021-10-26T18:10:15.618Z"}, {"entity": "publication", "iuid": "b708ee46f2fc46ba9e5b696c9ee88580", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b708ee46f2fc46ba9e5b696c9ee88580.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b708ee46f2fc46ba9e5b696c9ee88580"}}, "title": "Distress Levels of Parents of Children with Neurodevelopmental Disorders during the COVID-19 Pandemic: A Comparison between Italy and Australia.", "authors": [{"family": "Burnett", "given": "Dayle", "initials": "D", "orcid": "0000-0003-0943-7973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33de85e857374d3b813fa2a886b489f7.json"}}, {"family": "Masi", "given": "Anne", "initials": "A"}, {"family": "Mendoza Diaz", "given": "Antonio", "initials": "A"}, {"family": "Rizzo", "given": "Renata", "initials": "R"}, {"family": "Lin", "given": "Ping-I", "initials": "PI", "orcid": "0000-0002-9739-7184", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/359146aaef914f14873beee4b6b43bcf.json"}}, {"family": "Eapen", "given": "Valsamma", "initials": "V", "orcid": "0000-0001-6296-8306", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e5564f68ee14bc4ba80b06b06997f90.json"}}], "type": "journal article", "published": "2021-10-21", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "21", "issn-l": null}, "abstract": "Parents of children with a neurodevelopmental disorder (NDD) report higher levels of distress compared to those of typically developing children. Distress levels may be heightened by the restrictions associated with the COVID-19 pandemic. However, it is unclear whether distress levels of parents varied by the diagnosis of neurodevelopmental disorder in children during the COVID-19 pandemic. This study aims to investigate whether parental distress was influenced by the type of NDD. Participants were from Australia (N = 196) and Italy (N = 200); the parents of children aged 3-18 were invited to complete an online self-reported survey which included the 6-item Kessler Psychological Distress Scale (K6) to determine parental distress. The results show that intellectual or learning disorder (ILD) is a major contributor to parental distress compared to other NDDs in both Australia and Italy. Moreover, the worsening of symptomatic changes in children with NDDs was significantly associated with parental distress. The differences between the two countries in terms of the pandemic impact, however, were not statistically significant. The results suggest that intervention strategies need to be tailored for individual clinical information and factor in the society's stringency level of anti-contagion policies to improve parental wellbeing.", "doi": "10.3390/ijerph182111066", "pmid": "34769585", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182111066"}, {"db": "pmc", "key": "PMC8583226"}, {"db": "figshare", "key": "10.6084/m9. figshare.16528998"}], "notes": [], "created": "2021-11-26T15:10:38.936Z", "modified": "2021-11-26T15:10:48.513Z"}, {"entity": "publication", "iuid": "04f67edcbc33433ab52163c3ab8b2591", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/04f67edcbc33433ab52163c3ab8b2591.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/04f67edcbc33433ab52163c3ab8b2591"}}, "title": "Advances and Utility of the Human Plasma Proteome", "authors": [{"family": "Deutsch", "given": "Eric W", "initials": "EW", "orcid": "0000-0001-8732-0928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a79e829ef590450696ffa9be36818a15.json"}}, {"family": "Omenn", "given": "Gilbert S", "initials": "GS", "orcid": "0000-0002-8976-6074", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be6adfe65b8345da8799a7d6af35c38d.json"}}, {"family": "Sun", "given": "Zhi", "initials": "Z", "orcid": "0000-0003-3324-6851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bc55a74b03b412b86616badb068af08.json"}}, {"family": "Maes", "given": "Michal", "initials": "M", "orcid": "0000-0002-7406-3982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cff13791bbc0457a89657357e2f6febf.json"}}, {"family": "Pernemalm", "given": "Maria", "initials": "M", "orcid": "0000-0003-4624-031X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6801d3242ee544a59d77ccd7256a4a30.json"}}, {"family": "Palaniappan", "given": "Krishnan K", "initials": "KK", "orcid": "0000-0003-0203-9016", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0de4251e52634dfda3157543df4187c5.json"}}, {"family": "Letunica", "given": "Natasha", "initials": "N", "orcid": "0000-0003-3604-1536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40ecd7338e3245c3a25614938b63ecf1.json"}}, {"family": "Vandenbrouck", "given": "Yves", "initials": "Y", "orcid": "0000-0002-1292-373X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12d928faa9d642eda7c27008bf2a85a6.json"}}, {"family": "Brun", "given": "Virginie", "initials": "V", "orcid": "0000-0002-9098-8707", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff2f9882dc0c447fa7dfdfd812aeac75.json"}}, {"family": "Tao", "given": "Sheng ce", "initials": "Sc", "orcid": "0000-0002-9210-1823", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e5c94e5298840c38b9aabcdd91599ac.json"}}, {"family": "Yu", "given": "Xiaobo", "initials": "X"}, {"family": "Geyer", "given": "Philipp E", "initials": "PE", "orcid": "0000-0001-7980-4826", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cec492eb8b214af1b35c081249a43ef2.json"}}, {"family": "Ignjatovic", "given": "Vera", "initials": "V", "orcid": "0000-0002-5548-5813", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b94d0fd7f56d491785df601cb8851722.json"}}, {"family": "Moritz", "given": "Robert L", "initials": "RL", "orcid": "0000-0002-3216-9447", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2aa533b8b0cb46689bf9862952bbc417.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67a59fa5de37434c8b7151039c192a37.json"}}], "type": "journal-article", "published": "2021-10-21", "journal": {"title": "J. Proteome Res.", "issn": "1535-3893", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The study of proteins circulating in blood offers tremendous opportunities to diagnose, stratify, or possibly prevent diseases. With recent technological advances and the urgent need to understand the effects of COVID-19, the proteomic analysis of blood-derived serum and plasma has become even more important for studying human biology and pathophysiology. Here we provide views and perspectives about technological developments and possible clinical applications that use mass-spectrometry(MS)- or affinity-based methods. We discuss examples where plasma proteomics contributed valuable insights into SARS-CoV-2 infections, aging, and hemostasis and the opportunities offered by combining proteomics with genetic data. As a contribution to the Human Proteome Organization (HUPO) Human Plasma Proteome Project (HPPP), we present the Human Plasma PeptideAtlas build 2021-07 that comprises 4395 canonical and 1482 additional nonredundant human proteins detected in 240 MS-based experiments. In addition, we report the new Human Extracellular Vesicle PeptideAtlas 2021-06, which comprises five studies and 2757 canonical proteins detected in extracellular vesicles circulating in blood, of which 74% (2047) are in common with the plasma PeptideAtlas. Our overview summarizes the recent advances, impactful applications, and ongoing challenges for translating plasma proteomics into utility for precision medicine.", "doi": "10.1021/acs.jproteome.1c00657", "pmid": "34672606", "labels": {"Category: Biochemistry": null, "Type: Review": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.1021/acs.jproteome.1c00657.s002", "description": "Union of proteins in both the plasma and blood extracellular vesicle PeptideAtlas builds, along with the crudely estimated log10 abundances and functional annotations"}], "notes": [], "created": "2021-10-26T14:47:22.298Z", "modified": "2021-11-19T10:45:18.691Z"}, {"entity": "publication", "iuid": "0868bd77cf724196bd1351491fb6f27e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0868bd77cf724196bd1351491fb6f27e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0868bd77cf724196bd1351491fb6f27e"}}, "title": "Acute and post-acute neurological manifestations of COVID-19: present findings, critical appraisal, and future directions.", "authors": [{"family": "Beghi", "given": "Ettore", "initials": "E", "orcid": "0000-0003-2542-0469", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08608536dadb4c84af6f3ea9c0a9f7e4.json"}}, {"family": "Giussani", "given": "Giorgia", "initials": "G"}, {"family": "Westenberg", "given": "Erica", "initials": "E"}, {"family": "Allegri", "given": "Ricardo", "initials": "R"}, {"family": "Garcia-Azorin", "given": "David", "initials": "D"}, {"family": "Guekht", "given": "Alla", "initials": "A"}, {"family": "Frontera", "given": "Jennifer", "initials": "J"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Mangialasche", "given": "Francesca", "initials": "F"}, {"family": "Mukaetova-Ladinska", "given": "Elizabeta B", "initials": "EB"}, {"family": "Prasad", "given": "Kameshwar", "initials": "K"}, {"family": "Chowdhary", "given": "Neerja", "initials": "N"}, {"family": "Winkler", "given": "Andrea Sylvia", "initials": "AS"}], "type": "journal article", "published": "2021-10-21", "journal": {"title": "J Neurol", "issn": "1432-1459", "issn-l": null}, "abstract": "Acute and post-acute neurological symptoms, signs and diagnoses have been documented in an increasing number of patients infected by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which causes Coronavirus Disease 2019 (COVID-19). In this review, we aimed to summarize the current literature addressing neurological events following SARS-CoV-2 infection, discuss limitations in the existing literature and suggest future directions that would strengthen our understanding of the neurological sequelae of COVID-19. The presence of neurological manifestations (symptoms, signs or diagnoses) both at the onset or during SARS-CoV-2 infection is associated with a more severe disease, as demonstrated by a longer hospital stay, higher in-hospital death rate or the continued presence of sequelae at discharge. Although biological mechanisms have been postulated for these findings, evidence-based data are still lacking to clearly define the incidence, range of characteristics and outcomes of these manifestations, particularly in non-hospitalized patients. In addition, data from low- and middle-income countries are scarce, leading to uncertainties in the measure of neurological findings of COVID-19, with reference to geography, ethnicity, socio-cultural settings, and health care arrangements. As a consequence, at present a specific phenotype that would specify a post-COVID (or long-COVID) neurological syndrome has not yet been identified.", "doi": "10.1007/s00415-021-10848-4", "pmid": "34674005", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00415-021-10848-4"}], "notes": [], "created": "2021-10-26T18:10:35.291Z", "modified": "2021-10-26T18:10:47.822Z"}, {"entity": "publication", "iuid": "ede3ddee591a4d2492385a9f0b07bf27", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ede3ddee591a4d2492385a9f0b07bf27.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ede3ddee591a4d2492385a9f0b07bf27"}}, "title": "Twinning during the pandemic: Evidence of selection in utero.", "authors": [{"family": "Catalano", "given": "Ralph", "initials": "R", "orcid": "0000-0001-7240-415X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ccf81f67c4f46dc92acca88a7344cc9.json"}}, {"family": "Bruckner", "given": "Tim", "initials": "T"}, {"family": "Casey", "given": "Joan A", "initials": "JA"}, {"family": "Gemmill", "given": "Alison", "initials": "A", "orcid": "0000-0001-5879-9730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dca36e3db9724dce8360c5f7b362151d.json"}}, {"family": "Margerison", "given": "Claire", "initials": "C", "orcid": "0000-0003-0692-2252", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06be6014da274b2886af1733870d98b0.json"}}, {"family": "Hartig", "given": "Terry", "initials": "T"}], "type": "journal article", "published": "2021-10-20", "journal": {"title": "Evol Med Public Health", "issn": "2050-6201", "volume": "9", "issue": "1", "pages": "374-382", "issn-l": null}, "abstract": "The suspicion that a population stressor as profound as the COVID-19 pandemic would increase preterm birth among cohorts in gestation at its outset has not been supported by data collected in 2020. An evolutionary perspective on this circumstance suggests that natural selection in utero, induced by the onset of the pandemic, caused pregnancies that would otherwise have produced a preterm birth to end early in gestation as spontaneous abortions. We test this possibility using the odds of a live-born twin among male births in Norway as an indicator of the depth of selection in birth cohorts.\n\nWe apply Box-Jenkins methods to 50 pre-pandemic months to estimate counterfactuals for the nine birth cohorts in gestation in March 2020 when the first deaths attributable to SARS-CoV-2 infection occurred in Norway. We use Alwan and Roberts outlier detection methods to discover any sequence of outlying values in the odds of a live-born twin among male births in exposed birth cohorts.\n\nWe find a downward level shift of 27% in the monthly odds of a twin among male births beginning in May and persisting through the remainder of 2020.\n\nConsistent with evolutionary theory and selection in utero, birth cohorts exposed in utero to the onset of the COVID-19 pandemic yielded fewer male twins than expected.\n\nOur finding of fewer than expected male twin births during the onset of the COVID-19 pandemic provides more evidence that evolution continues to affect the characteristics and health of contemporary populations.", "doi": "10.1093/emph/eoab033", "pmid": "34858596", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "eoab033"}, {"db": "pmc", "key": "PMC8634460"}], "notes": [], "created": "2021-12-18T18:06:55.901Z", "modified": "2021-12-18T18:07:03.516Z"}, {"entity": "publication", "iuid": "c10ab7f808754f1a8e2812b74e8a7985", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c10ab7f808754f1a8e2812b74e8a7985.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c10ab7f808754f1a8e2812b74e8a7985"}}, "title": "Trends of Anger and Physical Aggression in Russian Women During COVID-19 Lockdown.", "authors": [{"family": "Klimovich-Mickael", "given": "Alexandra", "initials": "A"}, {"family": "Kubick", "given": "Norwin", "initials": "N"}, {"family": "Milanesi", "given": "Elena", "initials": "E"}, {"family": "Dobre", "given": "Maria", "initials": "M"}, {"family": "\u0141azarczyk", "given": "Marzena", "initials": "M"}, {"family": "Wijas", "given": "Baraba", "initials": "B"}, {"family": "Sacharczuk", "given": "Mariusz", "initials": "M"}, {"family": "Mickael", "given": "Michel-Edwar", "initials": "ME"}], "type": "journal article", "published": "2021-10-20", "journal": {"title": "Front Glob Womens Health", "issn": "2673-5059", "volume": "2", "pages": "698151", "issn-l": null}, "abstract": "The effect of social lockdown during the COVID-19 outbreak on female aggressiveness is not well known. The strict measures of lockdown have resulted in millions of people, worldwide, confined to their homes during the pandemic. However, the consequence of lockdown strategies on females' psychological status including aggressiveness has not yet been investigated. We conducted a cross-sectional study on 31 Russian females' homemakers who are participants in an online fitness platform to investigate the immediate anxiety, depression, and aggression experienced under strict lockdown measures. The participants were surveyed using the hospital anxiety depression scale (HADS) and the Buss-Perry Aggression Questionnaire. We used descriptive and statistical methods to investigate the prevalence of these emotions among two age groups (20-35 and 36-65 years). We found that moderate anxiety prevalence was 77.4% in the entire group while mild depression was 54.8%. Interestingly, the whole sample showed a high level of angriness (p = 0.0002) and physical aggression (p = 0.019). These two emotions seem to be more prevalent than other negative emotions such as hostility, verbal aggression. This relationship was not dependent on age. Overall, there is a significant worsening in female aggression that could lead to higher chances of female victimization and being subjected to partner violence. Future policies designing lockdown strategies should consider this effect on active female homemakers. Due to the small size of our cohort, our results are only indicative of data trends. Larger studies are still needed to confirm the current findings.", "doi": "10.3389/fgwh.2021.698151", "pmid": "34816235", "labels": {"Type: Journal article": null, "Topics: Register-based research": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8593940"}], "notes": [], "created": "2021-11-26T13:17:10.899Z", "modified": "2021-12-18T18:23:22.161Z"}, {"entity": "publication", "iuid": "475cebda2a5f43bc9184f6963321058d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/475cebda2a5f43bc9184f6963321058d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/475cebda2a5f43bc9184f6963321058d"}}, "title": "Socio-economic and psychological impact of COVID-19 pandemic in a Spanish cohort BIOVAL-D-COVID-19 study protocol.", "authors": [{"family": "Miranda-Mendizabal", "given": "Andrea", "initials": "A"}, {"family": "Recoder", "given": "Silvia", "initials": "S"}, {"family": "Sebastian", "given": "Ester Calbo", "initials": "EC"}, {"family": "Casajuana Closas", "given": "Marc", "initials": "M"}, {"family": "Leiva Ure\u00f1a", "given": "David", "initials": "D"}, {"family": "Manolov", "given": "Rumen", "initials": "R"}, {"family": "Matilla Santander", "given": "Nuria", "initials": "N"}, {"family": "Forero", "given": "Carlos G", "initials": "CG"}, {"family": "Castellv\u00ed", "given": "Pere", "initials": "P"}], "type": "journal article", "published": "2021-10-20", "journal": {"title": "Gac Sanit", "issn": "1578-1283", "issn-l": null}, "abstract": "SARS-CoV-2 outbreak has a negative psychological impact among general population. Data comparing mental health status before and during the outbreak is needed. The BIOVAL-D-COVID-19 study assess the socio-economic and psychological impact of the COVID-19 pandemic and lockdown in a representative sample of non-institutionalized Spanish adult population, and estimate the incidence of mental health disorders, including suicidal behaviours, and possible related factors.\n\nObservational longitudinal study including two online surveys: baseline survey (T0) performed during 2019 and follow-up survey (T1) conducted 12-month later. The latter included nine sections: socio-demographic, health status, mental health, employment conditions and status, material deprivation, use of healthcare services, intimate partner violence and resilience. Four of the nine sections are administered in T0 and T1 assessments. Longitudinal data analyses will estimate adjusted incidence rates of mental health disorders using Poisson regression models. Risk and protective factors will be analysed through multiple logistic regression models.", "doi": "10.1016/j.gaceta.2021.10.003", "pmid": "34836679", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0213-9111(21)00180-1"}, {"db": "pmc", "key": "PMC8526442"}], "notes": [], "created": "2021-12-18T18:13:46.340Z", "modified": "2021-12-18T18:14:03.345Z"}, {"entity": "publication", "iuid": "5ac427dcbd894ef981cceb9d3f478952", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5ac427dcbd894ef981cceb9d3f478952.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5ac427dcbd894ef981cceb9d3f478952"}}, "title": "Gender gap in journal submissions and peer review during the first wave of the COVID-19 pandemic. A study on 2329 Elsevier journals.", "authors": [{"family": "Squazzoni", "given": "Flaminio", "initials": "F", "orcid": "0000-0002-6503-6077", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b124ceca40884addab841186835c2e43.json"}}, {"family": "Bravo", "given": "Giangiacomo", "initials": "G", "orcid": "0000-0003-2837-0137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e2bd815dac24aabb080893c4d7d1051.json"}}, {"family": "Grimaldo", "given": "Francisco", "initials": "F", "orcid": "0000-0002-1357-7170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6be3f24db5f44f26ae1ed1fb16c5b760.json"}}, {"family": "Garc\u00eda-Costa", "given": "Daniel", "initials": "D"}, {"family": "Farjam", "given": "Mike", "initials": "M"}, {"family": "Mehmani", "given": "Bahar", "initials": "B", "orcid": "0000-0003-4038-4531", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bbbcfa3265dc4cd6a804e4515137ee1f.json"}}], "type": "journal article", "published": "2021-10-20", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0257919", "issn-l": "1932-6203"}, "abstract": "During the early months of the COVID-19 pandemic, there was an unusually high submission rate of scholarly articles. Given that most academics were forced to work from home, the competing demands for familial duties may have penalized the scientific productivity of women. To test this hypothesis, we looked at submitted manuscripts and peer review activities for all Elsevier journals between February and May 2018-2020, including data on over 5 million authors and referees. Results showed that during the first wave of the pandemic, women submitted proportionally fewer manuscripts than men. This deficit was especially pronounced among more junior cohorts of women academics. The rate of the peer-review invitation acceptance showed a less pronounced gender pattern with women taking on a greater service responsibility for journals, except for health & medicine, the field where the impact of COVID-19 research has been more prominent. Our findings suggest that the first wave of the pandemic has created potentially cumulative advantages for men.", "doi": "10.1371/journal.pone.0257919", "pmid": "34669713", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-15330"}], "notes": [], "created": "2021-10-21T04:37:34.903Z", "modified": "2021-10-21T04:37:35.057Z"}, {"entity": "publication", "iuid": "1992a95857644f16a0b3f26aeb5ed5af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1992a95857644f16a0b3f26aeb5ed5af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1992a95857644f16a0b3f26aeb5ed5af"}}, "title": "COVID-19: A comprehensive review of current guidelines and personal perspectives from neurointerventionists.", "authors": [{"family": "Lee", "given": "Seon-Kyu", "initials": "SK"}, {"family": "S\u00f6derman", "given": "Michael", "initials": "M"}, {"family": "Altschul", "given": "David J", "initials": "DJ", "orcid": "0000-0002-5130-1378", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8b7025f25174eec917fe4491b64765d.json"}}], "type": "journal article", "published": "2021-10-20", "journal": {"title": "Interv Neuroradiol", "issn": "2385-2011", "pages": "15910199211037807", "issn-l": null}, "abstract": null, "doi": "10.1177/15910199211037807", "pmid": "34669531", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-10-21T04:38:02.457Z", "modified": "2021-10-21T04:38:17.971Z"}, {"entity": "publication", "iuid": "cc6244441ef447f6834249322c7adfc4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc6244441ef447f6834249322c7adfc4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc6244441ef447f6834249322c7adfc4"}}, "title": "The role of ventilatory support for long-term outcomes after critical infection with COVID-19: A prospective cohort study.", "authors": [{"family": "Hanna", "given": "Gabriel", "initials": "G"}, {"family": "Bankler", "given": "Sara", "initials": "S"}, {"family": "Schandl", "given": "Anna", "initials": "A"}, {"family": "Ro\u00ebl", "given": "Mari", "initials": "M"}, {"family": "Hedman", "given": "Anders", "initials": "A"}, {"family": "Franko", "given": "Mikael Andersson", "initials": "MA"}, {"family": "Lyng\u00e5", "given": "Patrik", "initials": "P"}, {"family": "Geborek", "given": "Anne", "initials": "A"}, {"family": "Joelsson-Alm", "given": "Eva", "initials": "E", "orcid": "0000-0002-9041-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07a091265e654b21bc27fa14b93e4ec0.json"}}, {"family": "S\u00f6derberg", "given": "M\u00e5rten", "initials": "M"}, {"family": "Darlington", "given": "Pernilla", "initials": "P"}], "type": "journal article", "published": "2021-10-19", "journal": {"title": "Clin Respir J", "issn": "1752-699X", "issn-l": null}, "abstract": "The full range of long-term health consequences in ICU survivors with COVID-19 is unclear. This study aims to investigate the role of ventilatory support for long-term pulmonary impairment in critically ill patients and further to identify risk factors for prolonged radiological recovery.\n\nA prospective observational study from a single general hospital, including all with COVID-19 admitted to ICU between March and August 2020, investigating the association between ventilatory support and the extent of residual parenchymal changes on chest CT scan and measurement of lung volumes at follow-up comparing high-flow nasal oxygen (HFNO) or non-invasive ventilation (NIV) with invasive ventilation. A semi-quantitative score (CT involvement score) based on lobar involvement and a total score for all five lobes was used to estimate residual parenchymal changes. The association was calculated with logistic regression and adjusted for age, sex, smoking and severity of illness.\n\nAmong the 187 eligible, 86 had a chest CT scan and 76 a pulmonary function test at the follow-up with a median time of six months after ICU discharge. Residual lung changes were seen in 74%. The extent of pulmonary changes was similar regardless of ventilatory support, but patients with invasive ventilation had a lower total lung capacity 84% vs 92% of predicted (p<0.001).\n\nThe majority of ICU-treated patients with COVID-19 had residual lung changes at six months follow-up regardless of ventilator support or not, but the total lung capacity was lower in those treated with invasive ventilation.", "doi": "10.1111/crj.13453", "pmid": "34665518", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-21T04:53:21.266Z", "modified": "2021-10-21T04:53:21.356Z"}, {"entity": "publication", "iuid": "8d53640d5b78486ba15544de1fdba5cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d53640d5b78486ba15544de1fdba5cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d53640d5b78486ba15544de1fdba5cf"}}, "title": "Social Distancing Policies in the Coronavirus Battle: A Comparison of Denmark and Sweden.", "authors": [{"family": "Seing", "given": "Ida", "initials": "I"}, {"family": "Th\u00f3rn\u00fd Stef\u00e1nsd\u00f3ttir", "given": "Nina", "initials": "N", "orcid": "0000-0002-7748-5347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c7da04bf6284cab9a62b9d6faf64b06.json"}}, {"family": "Wassar Kirk", "given": "Jeanette", "initials": "J", "orcid": "0000-0002-2680-0917", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f32255961c141298acfba1fbaac9824.json"}}, {"family": "Andersen", "given": "Ove", "initials": "O"}, {"family": "Tj\u00f8rnh\u00f8j-Thomsen", "given": "Tine", "initials": "T"}, {"family": "Kallemose", "given": "Thomas", "initials": "T"}, {"family": "Vedung", "given": "Evert", "initials": "E"}, {"family": "Vrangb\u00e6k", "given": "Karsten", "initials": "K"}, {"family": "Nilsen", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2021-10-19", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "20", "pages": null}, "abstract": "Social distancing measures have been a key component in government strategies to mitigate COVID-19 globally. Based on official documents, this study aimed to identify, compare and analyse public social distancing policy measures adopted in Denmark and Sweden regarding the coronavirus from 1 March 2020 until 1 October 2020. A key difference was the greater emphasis on laws and executive orders (sticks) in Denmark, which allowed the country to adopt many stricter policy measures than Sweden, which relied mostly on general guidelines and recommendations (sermons). The main policy adopters in Denmark were the government and the Danish Parliament, whereas the Public Health Agency issued most policies in Sweden, reflecting a difference in political governance and administrative structure in the two countries. During the study period, Sweden had noticeably higher rates of COVID-19 deaths and hospitalizations per 100,000 population than Denmark, yet it is difficult to determine the impact or relative effectiveness of sermons and sticks, particularly with regard to broader and longer-term health, economic and societal effects.", "doi": "10.3390/ijerph182010990", "pmid": "34682734", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph182010990"}], "notes": [], "created": "2021-10-26T18:16:33.651Z", "modified": "2022-02-17T12:04:44.526Z"}, {"entity": "publication", "iuid": "ba97b2dc080946b7997eb15dcd2e098f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ba97b2dc080946b7997eb15dcd2e098f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ba97b2dc080946b7997eb15dcd2e098f"}}, "title": "Lack of Trust, Insufficient knowledge and Risk denial; an in-depth Understanding of Health workers Barriers to uptake of the Covid-19 vaccine at Iganga Hospital Eastern Uganda, and Mengo Hospital Kampala Uganda", "authors": [{"family": "Muhamadi", "given": "Lubega", "initials": "L"}, {"family": "Edith", "given": "Namulema", "initials": "N"}, {"family": "James", "given": "Waako", "initials": "W"}, {"family": "Tumwesigye", "given": "Nazarius Mbona", "initials": "NM"}, {"family": "Museene", "given": "Safinah Kisu", "initials": "SK"}, {"family": "Mukakaarisa", "given": "Hellen", "initials": "H"}, {"family": "Peterson", "given": "Stefan Swartling", "initials": "SS"}, {"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM"}], "type": "posted-content", "published": "2021-10-19", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.10.13.21264920", "pmid": null, "labels": {"Category: Public Health": null, "Type: Preprint": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:41:01.093Z", "modified": "2021-11-29T06:08:28.303Z"}, {"entity": "publication", "iuid": "4efc878827a54611ba59ad34ee90434b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4efc878827a54611ba59ad34ee90434b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4efc878827a54611ba59ad34ee90434b"}}, "title": "Impact of SARS-CoV-2 infection on vaccine-induced immune responses over time", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Ng", "given": "Henry", "initials": "H"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "posted-content", "published": "2021-10-19", "journal": {"title": "MedRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.10.16.21264948", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Health": null, "Research Area: High-throughput and high-content serology": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-11-18T16:32:34.201Z", "modified": "2023-06-19T14:28:13.106Z"}, {"entity": "publication", "iuid": "14d8fb377fab4b9ba81680ee27e65d48", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/14d8fb377fab4b9ba81680ee27e65d48.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/14d8fb377fab4b9ba81680ee27e65d48"}}, "title": "Humoral and cellular response to SARS-CoV-2 BNT162b2 mRNA vaccine in hemodialysis patients.", "authors": [{"family": "Melin", "given": "Jan", "initials": "J", "orcid": "0000-0003-3405-3154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e749d7c3ad7e40cfbb1f3bfda19ec05b.json"}}, {"family": "Svensson", "given": "Maria K", "initials": "MK"}, {"family": "Albinsson", "given": "Bo", "initials": "B"}, {"family": "Winqvist", "given": "Ola", "initials": "O"}, {"family": "Pauksens", "given": "Karlis", "initials": "K"}], "type": "journal article", "published": "2021-10-19", "journal": {"title": "BMC Immunol", "issn": "1471-2172", "issn-l": null, "volume": "22", "issue": "1", "pages": "70"}, "abstract": "Hemodialysis (HD) patients have an increased risk of acquiring infections due to many health care contacts and may, in addition, have a suboptimal response to vaccination and a high mortality from Covid-19 infection.\n\nIn 50 HD patients (mean age 69.4 years, 62% men) administration of SARS-CoV-2BNT162b2 mRNA vaccine began in Dec 2020 and the immune response was evaluated 7-15 weeks after the last dose. Levels of Covid-19 (SARS-CoV-2) IgG antibody against the nucleocapsid antigen (anti-N) and the Spike antigen (anti-S) and T-cell reactivity testing against the Spike protein using ELISPOT technology were evaluated.\n\nOut of 50 patients, anti-S IgG antibodies indicating a vaccine effect or previous Covid-19 infection, were detected in 37 (74%), 5 (10%) had a borderline response and 8 (16%) were negative after two doses of vaccine. T-cell responses were detected in 29 (58%). Of the 37 patients with anti-S antibodies, 25 (68%) had a measurable T-cell response. 2 (40%) out of 5 patients with borderline anti-S and 2 (25%) without anti-S had a concomitant T-cell response. Twenty-seven (54%) had both an antibody and T-cell response. IgG antibodies to anti-N indicating a previous Covid-19 disease were detected in 7 (14%) patients.\n\nMost HD patients develop a B- and/or T-cell response after vaccination against Covid-19 but approx. 20% had a limited immunological response. T-cell reactivity against Covid-19 was only present in a few of the anti-S antibody negative patients.", "doi": "10.1186/s12865-021-00458-0", "pmid": "34666683", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC8524400"}, {"db": "pii", "key": "10.1186/s12865-021-00458-0"}], "notes": [], "created": "2021-10-21T04:48:27.665Z", "modified": "2023-06-19T15:31:31.358Z"}, {"entity": "publication", "iuid": "f33dd0f2b2b84264b595cd9fd28bff7c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f33dd0f2b2b84264b595cd9fd28bff7c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f33dd0f2b2b84264b595cd9fd28bff7c"}}, "title": "Drug repurposing improves disease targeting 11-fold and can be augmented by network module targeting, applied to COVID-19.", "authors": [{"family": "Rivero-Garc\u00eda", "given": "In\u00e9s", "initials": "I"}, {"family": "Castresana-Aguirre", "given": "Miguel", "initials": "M"}, {"family": "Guglielmo", "given": "Luca", "initials": "L"}, {"family": "Guala", "given": "Dimitri", "initials": "D"}, {"family": "Sonnhammer", "given": "Erik L L", "initials": "ELL"}], "type": "journal article", "published": "2021-10-19", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "20687", "issn-l": "2045-2322"}, "abstract": "This analysis presents a systematic evaluation of the extent of therapeutic opportunities that can be obtained from drug repurposing by connecting drug targets with disease genes. When using FDA-approved indications as a reference level we found that drug repurposing can offer an average of an 11-fold increase in disease coverage, with the maximum number of diseases covered per drug being increased from 134 to 167 after extending the drug targets with their high confidence first neighbors. Additionally, by network analysis to connect drugs to disease modules we found that drugs on average target 4 disease modules, yet the similarity between disease modules targeted by the same drug is generally low and the maximum number of disease modules targeted per drug increases from 158 to 229 when drug targets are neighbor-extended. Moreover, our results highlight that drug repurposing is more dependent on target proteins being shared between diseases than on polypharmacological properties of drugs. We apply our drug repurposing and network module analysis to COVID-19 and show that Fostamatinib is the drug with the highest module coverage.", "doi": "10.1038/s41598-021-99721-y", "pmid": "34667255", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-99721-y"}, {"db": "URL", "key": "https://bitbucket.org/sonnhammergroup/unadrug", "description": "Code, raw data, analysis results, and figures are all available in bitbucket"}], "notes": [], "created": "2021-10-21T04:41:29.287Z", "modified": "2021-11-08T09:51:37.313Z"}, {"entity": "publication", "iuid": "c2942d61f471452ba1028a411f33f4a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2942d61f471452ba1028a411f33f4a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2942d61f471452ba1028a411f33f4a9"}}, "title": "Cardiorespiratory fitness and lifestyle on severe COVID-19 risk in 279,455 adults: a case control study.", "authors": [{"family": "Ekblom-Bak", "given": "Elin", "initials": "E", "orcid": "0000-0002-3901-7833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08a43b5b45864543a2583be45a2f1d10.json"}}, {"family": "V\u00e4is\u00e4nen", "given": "Daniel", "initials": "D"}, {"family": "Ekblom", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Blom", "given": "Victoria", "initials": "V"}, {"family": "Kallings", "given": "Lena V", "initials": "LV"}, {"family": "Hemmingsson", "given": "Erik", "initials": "E"}, {"family": "Andersson", "given": "Gunnar", "initials": "G"}, {"family": "Wallin", "given": "Peter", "initials": "P"}, {"family": "Salier Eriksson", "given": "Jane", "initials": "J"}, {"family": "Holmlund", "given": "Tobias", "initials": "T"}, {"family": "Lindwall", "given": "Magnus", "initials": "M"}, {"family": "Stenling", "given": "Andreas", "initials": "A"}, {"family": "L\u00f6nn", "given": "Amanda", "initials": "A"}], "type": "journal article", "published": "2021-10-19", "journal": {"title": "Int J Behav Nutr Phys Act", "issn": "1479-5868", "volume": "18", "issue": "1", "pages": "135", "issn-l": null}, "abstract": "The impact of cardiorespiratory fitness (CRF) and other lifestyle-related factors on severe COVID-19 risk is understudied. The present study aims to investigate lifestyle-related and socioeconomic factors as possible predictors of COVID-19, with special focus on CRF, and to further study whether these factors may attenuate obesity- and hypertension-related risks, as well as mediate associations between socioeconomic factors and severe COVID-19 risk.\n\nOut of initially 407,131 participants who participated in nationwide occupational health service screening between 1992 and 2020, n = 857 cases (70% men, mean age 49.9 years) of severe COVID-19 were identified. CRF was estimated using a sub-maximum cycle test, and other lifestyle variables were self-reported. Analyses were performed including both unmatched, n = 278,598, and sex-and age-matched, n = 3426, controls. Severe COVID-19 included hospitalization, intensive care or death due to COVID-19.\n\nPatients with more severe COVID-19 had significantly lower CRF, higher BMI, a greater presence of comorbidities and were more often daily smokers. In matched analyses, there was a graded decrease in odds for severe COVID-19 with each ml in CRF (OR = 0.98, 95% CI 0.970 to 0.998), and a two-fold increase in odds between the lowest and highest (< 32 vs. \u2265 46 ml\u00b7min-1\u00b7kg-1) CRF group. Higher BMI (per unit increase, OR = 1.09, 1.06 to 1.12), larger waist circumference (per cm, OR = 1.04, 1.02 to 1.06), daily smoking (OR = 0.60, 0.41 to 0.89) and high overall stress (OR = 1.36, 1.001 to 1.84) also remained significantly associated with severe COVID-19 risk. Obesity- and blood pressure-related risks were attenuated by adjustment for CRF and lifestyle variables. Mediation through CRF, BMI and smoking accounted for 9% to 54% of the associations between low education, low income and blue collar/low skilled occupations and severe COVID-19 risk. The results were consistent using either matched or unmatched controls.\n\nBoth lifestyle-related and socioeconomic factors were associated with risk of severe COVID-19. However, higher CRF attenuated the risk associated with obesity and high blood pressure, and mediated the risk associated with various socioeconomic factors. This emphasises the importance of interventions to maintain or increase CRF in the general population to strengthen the resilience to severe COVID-19, especially in high-risk individuals.", "doi": "10.1186/s12966-021-01198-5", "pmid": "34666788", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12966-021-01198-5"}], "notes": [], "created": "2021-10-21T04:47:47.784Z", "modified": "2021-10-21T04:47:47.858Z"}, {"entity": "publication", "iuid": "78490315e34845a5b5594d5e796d14d6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/78490315e34845a5b5594d5e796d14d6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/78490315e34845a5b5594d5e796d14d6"}}, "title": "COVID-19 mortality across occupations and secondary risks for elderly individuals in the household: A population register-based study.", "authors": [{"family": "Billingsley", "given": "Sunnee", "initials": "S"}, {"family": "Brand\u00e9n", "given": "Maria", "initials": "M"}, {"family": "Aradhya", "given": "Siddartha", "initials": "S"}, {"family": "Drefahl", "given": "Sven", "initials": "S"}, {"family": "Andersson", "given": "Gunnar", "initials": "G"}, {"family": "Mussino", "given": "Eleonora", "initials": "E"}], "type": "journal article", "published": "2021-10-19", "journal": {"title": "Scand J Work Environ Health", "issn": "1795-990X", "issn-l": null}, "abstract": "Objectives This is the first population-level study to examine inequalities in COVID-19 mortality according to working-age individuals' occupations and the indirect occupational effects on COVID-19 mortality of older individuals who live with them. Methods We used early-release data for the entire population of Sweden of all recorded COVID-19 deaths from 12 March 2020 to 23 February 2021, which we linked to administrative registers and occupational measures. Cox proportional hazard models assessed relative risks of COVID-19 mortality for the working-aged population registered in an occupation in December 2018 and the older population who lived with them. Results Among working aged-adults, taxi/bus drivers had the highest relative risk of COVID-19 mortality: over four times that of skilled workers in IT, economics, or administration when adjusted only for basic demographic characteristics. After adjusting for socioeconomic factors (education, income and country of birth), there are no occupational groups with clearly elevated (statistically significant) COVID-19 mortality. Neither a measure of exposure within occupations nor the share that generally can work from home were related to working-aged adults' risk of COVID-19 mortality. Instead of occupational factors, traditional socioeconomic risk factors best explained variation in COVID-19 mortality. Elderly individuals, however, faced higher COVID-19 mortality risk both when living with a delivery or postal worker or worker(s) in occupations that generally work from home less, even when their socioeconomic factors are taken into account. Conclusions Inequalities in COVID-19 mortality of working-aged adults were mostly based on traditional risk factors and not on occupational divisions or characteristics in Sweden. However, older individuals living with those who likely cannot work from home or work in delivery or postal services were a vulnerable group.", "doi": "10.5271/sjweh.3992", "pmid": "34665872", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "3992"}], "notes": [], "created": "2021-10-21T04:50:35.692Z", "modified": "2021-10-21T04:50:35.707Z"}, {"entity": "publication", "iuid": "d8ef63726b3b45bcb96b054a6655d41e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d8ef63726b3b45bcb96b054a6655d41e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d8ef63726b3b45bcb96b054a6655d41e"}}, "title": "Role and utility of COVID-19 laboratory testing in low-income and middle-income countries: protocol for rapid evidence synthesis.", "authors": [{"family": "Ouma", "given": "Ojiambo Kevin", "initials": "OK"}, {"family": "Ephraim", "given": "Kisangala", "initials": "K"}, {"family": "Loyce", "given": "Nakalembe", "initials": "N"}, {"family": "Namisango", "given": "Eve", "initials": "E"}, {"family": "Nalugoda", "given": "Fred", "initials": "F"}, {"family": "Ndagire", "given": "Regina", "initials": "R"}, {"family": "Wangi", "given": "Rachel Nante", "initials": "RN", "orcid": "0000-0002-6589-2535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1b0dbf50f5f4bbaafb75643f527f0ca.json"}}, {"family": "Kawala", "given": "Brenda Allen", "initials": "BA"}, {"family": "Katairo", "given": "Thomas", "initials": "T", "orcid": "0000-0002-2002-8911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6711071ed8b0441d94f931c7ae884683.json"}}, {"family": "Okullo", "given": "Allen Eva", "initials": "AE"}, {"family": "Apunyo", "given": "Robert", "initials": "R"}, {"family": "Semakula", "given": "Daniel", "initials": "D", "orcid": "0000-0002-0806-213X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ed9d8d3a7aa44ad8443b2310f58fbd7.json"}}, {"family": "Luwambo", "given": "Ash", "initials": "A"}, {"family": "Kinengyere", "given": "Alison Annet", "initials": "AA"}, {"family": "Sewankambo", "given": "Nelson", "initials": "N"}, {"family": "Balinda", "given": "Sheila N", "initials": "SN"}, {"family": "Ocan", "given": "Moses", "initials": "M", "orcid": "0000-0002-8852-820X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de5a2ad5cc524e91851f35ea9ff821b3.json"}}, {"family": "Obuku", "given": "Ekwaro A", "initials": "EA"}], "type": "journal article", "published": "2021-10-18", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "10", "pages": "e050296", "issn-l": "2044-6055"}, "abstract": "Accurate and affordable laboratory testing is key to timely diagnosis and appropriate management of patients with COVID-19. New laboratory test protocols are released into the market under emergency use authorisation with limited evidence on diagnostic test accuracy. As such, robust evidence on the diagnostic accuracy and the costs of available tests is urgently needed to inform policy and practice especially in resource-limited settings. We aim to determine the diagnostic test accuracy, cost-effectiveness and utility of laboratory test strategies for COVID-19 in low-income and middle-income countries.\n\nThis will be a multistaged, protocol-driven systematic review conducted in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for diagnostic test accuracy studies. We will search for relevant literature in at least six public health databases, including PubMed, Google Scholar, MEDLINE, Scopus, Web of Science and the WHO Global Index Medicus. In addition, we will search Cochrane Library, COVID-END and grey literature databases to identify additional relevant articles before double-screening and abstraction of data. We will conduct a structured narrative and quantitative synthesis of the results guided by the Fryback and Thornbury framework for assessing a diagnostic test. The primary outcome is COVID-19 diagnostic test accuracy. Using the GRADE approach specific to diagnostic accuracy tests, we will appraise the overall quality of evidence and report the results following the original PRISMA statement. The protocol is registered with the International Prospective Register of Systematic Reviews (PROSPERO; https://www.crd.york.ac.uk/prospero/).\n\nEthical review was done by the School of Biomedical Sciences Research Ethics Committee and the Uganda National Council for Science and Technology. The published article will be accessible to policy and decision makers. The findings of this review will guide clinical practice and policy decisions and highlight areas for future research.PROSPERO registration number CRD42020209528.", "doi": "10.1136/bmjopen-2021-050296", "pmid": "34663660", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-050296"}], "notes": [], "created": "2021-10-21T04:58:00.330Z", "modified": "2021-10-21T04:58:09.820Z"}, {"entity": "publication", "iuid": "be07526407fe48d398cc79e1536de2d3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be07526407fe48d398cc79e1536de2d3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be07526407fe48d398cc79e1536de2d3"}}, "title": "Migrant workers occupational health research: an OMEGA-NET working group position paper.", "authors": [{"family": "Aktas", "given": "Emine", "initials": "E", "orcid": "0000-0003-2635-7588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e067735686ea462ead1cbe50348d7c04.json"}}, {"family": "Bergbom", "given": "Barbara", "initials": "B", "orcid": "0000-0002-5245-6419", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18083a7cae13485b94ec1cb2a36ea810.json"}}, {"family": "Godderis", "given": "Lode", "initials": "L", "orcid": "0000-0003-4764-8835", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/639b8bdac78742e9aeebe5b33c6dfedb.json"}}, {"family": "Kreshpaj", "given": "Bertina", "initials": "B", "orcid": "0000-0002-2991-6026", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d89b188538b64d6ca022b92c85cd0cf1.json"}}, {"family": "Marinov", "given": "Mario", "initials": "M"}, {"family": "Mates", "given": "Dana", "initials": "D"}, {"family": "McElvenny", "given": "Damien M", "initials": "DM", "orcid": "0000-0003-0953-8336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ffabe7c996ff4f47af509448b20dff49.json"}}, {"family": "Mehlum", "given": "Ingrid Sivesind", "initials": "IS", "orcid": "0000-0003-0830-284X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2366026a9d564a11b0bac13f7a8d3115.json"}}, {"family": "Milenkova", "given": "Valentina", "initials": "V"}, {"family": "Nena", "given": "Evangelia", "initials": "E", "orcid": "0000-0003-0381-4715", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d0b80af9262c45bbaff8afbefc515733.json"}}, {"family": "Glass", "given": "Deborah C", "initials": "DC", "orcid": "0000-0002-7559-008X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1185128471f4cc090044359d8df3b5d.json"}}], "type": "journal article", "published": "2021-10-18", "journal": {"title": "Int Arch Occup Environ Health", "issn": "1432-1246", "issn-l": null}, "abstract": "The aims of the study were: (1) to clarify the definitions of \"migrant\" used in occupational health research; (2) to summarize migrant workers' industry sectors, occupations and employment conditions; (3) to identify the occupational health and safety services available to migrant workers; (4) to summarize work-related health problems found among migrant workers; (5) to identify the methodological challenges to research into occupational health of migrant workers; and (6) to recommend improvements in migrant occupational health research.\n\nThis position paper was prepared by researchers from several European countries and Australia, working within the EU COST Action OMEGA-NET. The paper drew on two recent systematic reviews on the occupational health of international migrant workers and other literature, and also identified uncertainties and gaps in the research literature. Migrants may, for example, be temporary or permanent, moving for specific jobs migrants or other reasons. Their ethnicity and language capabilities will affect their work opportunities.\n\nThe occupational health literature seldom adequately identifies the heterogeneity or characteristics of the migrant group being studied. Migrants tend to work in more physically and mentally demanding environments with higher exposures than native workers. Migrants tend to have an increased risk of physical and mental ill health, but less access to health care services. This has been demonstrated recently by high rates of COVID-19 and less access to health care. There have been a number of cross-sectional studies of migrant health but few long-term cohort studies were identified. Other study designs, such as registry-based studies, surveys and qualitative studies may complement cross-sectional studies. Mixed-methodology studies would be valuable in research on migrants' occupational health. Language and lack of trust are barriers to migrant research participation.\n\nTargeted research, especially longitudinal, identifying how these economically important but often-vulnerable workers can be best assisted is needed. Researchers should identify the characteristics of the migrant workers that they are studying including visa/migration circumstances (temporary, permanent, undocumented), racial and ethnic characteristics, existing skills and language abilities.", "doi": "10.1007/s00420-021-01803-x", "pmid": "34661721", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00420-021-01803-x"}], "notes": [], "created": "2021-10-21T04:59:08.484Z", "modified": "2021-10-21T04:59:08.786Z"}, {"entity": "publication", "iuid": "d1e27ffd876749519ad5c92de8ceb231", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1e27ffd876749519ad5c92de8ceb231.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1e27ffd876749519ad5c92de8ceb231"}}, "title": "How the COVID-19 pandemic affects transgender health care - A cross-sectional online survey in 63 upper-middle-income and high-income countries.", "authors": [{"family": "Koehler", "given": "Andreas", "initials": "A", "orcid": "0000-0003-0415-3007", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6f71cad12f54442b7c37a3ca124148b.json"}}, {"family": "Motmans", "given": "Joz", "initials": "J", "orcid": "0000-0001-7643-4153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e84b4ee717654f5d9e0c102cb396a249.json"}}, {"family": "Muli\u00f3 Alvarez", "given": "Leo", "initials": "L"}, {"family": "Azul", "given": "David", "initials": "D", "orcid": "0000-0002-9181-8582", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/843fa6d772084e38a549235a1c80cc75.json"}}, {"family": "Badalyan", "given": "Karen", "initials": "K"}, {"family": "Basar", "given": "Koray", "initials": "K"}, {"family": "Dhejne", "given": "Cecilia", "initials": "C"}, {"family": "Dui\u0161in", "given": "Dragana", "initials": "D"}, {"family": "Grabski", "given": "Bartosz", "initials": "B", "orcid": "0000-0002-6268-2647", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c02c6d9cc5ff44729bb5e1bbc1be6151.json"}}, {"family": "Dufrasne", "given": "Aurore", "initials": "A"}, {"family": "Jokic-Begic", "given": "Natasa", "initials": "N", "orcid": "0000-0003-2597-535X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9bb577af0fc44464a6937b22d3c71524.json"}}, {"family": "Prunas", "given": "Antonio", "initials": "A"}, {"family": "Richards", "given": "Christina", "initials": "C"}, {"family": "Sabir", "given": "Kirill", "initials": "K"}, {"family": "Veale", "given": "Jaimie", "initials": "J"}, {"family": "Nieder", "given": "Timo Ole", "initials": "TO", "orcid": "0000-0003-3052-5169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a8f6f000cf144a293658031d5ff9ba4.json"}}], "type": "journal article", "published": "2021-10-18", "journal": {"title": "Int J Transgend Health", "issn": "2689-5277", "issn-l": null, "volume": "24", "issue": "3", "pages": "346-359"}, "abstract": "Due to the COVID-19 pandemic, access to medical care is restricted for nearly all non-acute conditions. Due to their status as a vulnerable social group and the inherent need for transition-related treatments, transgender people are assumed to be affected particularly severely by the restrictions caused by the COVID-19 pandemic.\r\n\r\nAs an ad hoc collaboration between researchers, clinicians and 23 community organizations, we developed a web-based survey in German that was translated into 26 languages. Participants were recruited via community sources, social media channels, and snowball sampling since May 2020. The present sample is based on the data collected until August 9, 2020. We assessed demographical data, health problems, risk factors, COVID-19 data (e.g., contact history), and the influence of the COVID-19 pandemic on access to transgender health care services. To identify factors associated with the experience of restrictions, we conducted multiple logistic regression analysis.\r\n\r\n5267 transgender people from 63 upper-middle-income and high-income countries participated in the study. Over 50% of the participants had risk factors for a severe course of a COVID-19 infection and were at a high risk of avoiding COVID-19 treatment due to the fear of mistreatment or discrimination. Access to transgender health care services was restricted for 50% of the participants. Male sex assigned at birth and a lower monthly income were significant predictors for the experience of restrictions to health care. 35.0% reported at least one mental health condition and 3.2% have attempted suicide since the beginning of the COVID-19 pandemic.\r\n\r\nTransgender people suffer under the severity of the pandemic due to the intersections between their status as a vulnerable social group, their high number of medical risk factors, and their need for ongoing medical treatment. The COVID-19 pandemic can potentiate these vulnerabilities, add new challenges for transgender people, and, therefore, can lead to devastating consequences, like severe physical or mental health issues, self-harming behavior, and suicidality.", "doi": "10.1080/26895269.2021.1986191", "pmid": "37519919", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC10373616"}, {"db": "pii", "key": "1986191"}], "notes": [], "created": "2023-10-04T12:12:44.096Z", "modified": "2023-10-04T13:33:45.009Z"}, {"entity": "publication", "iuid": "0d9c8a32320f4f6981c3a502a9fee2db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d9c8a32320f4f6981c3a502a9fee2db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d9c8a32320f4f6981c3a502a9fee2db"}}, "title": "Effectiveness of heterologous ChAdOx1 nCoV-19 and mRNA prime-boost vaccination against symptomatic Covid-19 infection in Sweden: A nationwide cohort study.", "authors": [{"family": "Nordstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Ballin", "given": "Marcel", "initials": "M"}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-10-18", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "issn-l": null, "volume": null, "issue": null, "pages": "100249"}, "abstract": "The effectiveness of heterologous prime-boost Coronavirus disease 2019 (Covid-19) vaccination is currently unknown.\r\n\r\nFrom individuals vaccinated with two doses against Covid-19 in Sweden until July 5, 2021 (N=3,445,061), we formed a study cohort including 94,569 individuals that had received heterologous ChAdOx1 nCoV-19 / BNT162b2 prime-boost vaccination, 16,402 individuals that received heterologous ChAdOx1 nCoV-19 / mRNA-1273 prime-boost vaccination, and 430,100 individuals that received homologous ChAdOx1 nCoV-19 / ChAdOx1 nCoV-19 prime-boost vaccination. In addition, 180,716 individuals were selected who were unvaccinated at the date of vaccination in the corresponding case. Unvaccinated individuals were censored at first dose of any vaccine. Baseline was the date of the second dose of any vaccine, with the same date in the corresponding unvaccinated individual. The outcome included incident symptomatic Covid-19 infection occurring >14 days after baseline.\r\n\r\nDuring a mean follow-up time of 76 (range 1-183) days, symptomatic Covid-19 infection was confirmed in 187 individuals with heterologous vaccine schedules (incidence rate: 2.0/100,000 person-days) and in 306 individuals from the unvaccinated control group (incidence rate: 7.1/100,000 person-days). The adjusted vaccine effectiveness was 67% (95% CI, 59-73, P<0.001) for heterologous ChAdOx1 nCoV-19 / BNT162b2 prime-boost vaccination, and 79% (95% CI, 62-88, P<0.001) for heterologous ChAdOx1 nCoV-19 / mRNA-1273 prime-boost vaccination. When combined and analysed together, the two heterologous vaccine schedules had an effectiveness of 68% (95% CI, 61-74, P<0.001) which was significantly greater (Pinteraction<0.001) than the 50% effectiveness for homologous ChAdOx1 nCoV-19 / ChAdOx1 nCoV-19 (95% CI, 41-58, P<0.001).\r\n\r\nThe findings of this study suggest that the use of heterologous ChAdOx1 nCoV-19 and mRNA prime-boost vaccination is an effective alternative to increase population immunity against Covid-19, including against the Delta variant which dominated the confirmed cases during the study period. These findings could have important implications for vaccination strategies and logistics, and consequently in the battle against the Covid-19 pandemic.", "doi": "10.1016/j.lanepe.2021.100249", "pmid": "34693387", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00235-0"}, {"db": "pmc", "key": "PMC8520818"}], "notes": [], "created": "2021-10-26T18:25:41.189Z", "modified": "2021-12-07T15:23:48.364Z"}, {"entity": "publication", "iuid": "2f8b9fb8a6854364a925caae0ef582ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2f8b9fb8a6854364a925caae0ef582ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2f8b9fb8a6854364a925caae0ef582ee"}}, "title": "Pregnancy and risk of COVID-19: a Norwegian registry-linkage study.", "authors": [{"family": "Magnus", "given": "Maria C", "initials": "MC", "orcid": "0000-0002-0568-3774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3530918cfd534021a45a80628c89c580.json"}}, {"family": "Oakley", "given": "Laura", "initials": "L"}, {"family": "Gjessing", "given": "H\u00e5kon K", "initials": "HK"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}, {"family": "Engjom", "given": "Hilde M", "initials": "HM"}, {"family": "Macsali", "given": "Ferenc", "initials": "F"}, {"family": "Juliusson", "given": "Petur B", "initials": "PB"}, {"family": "Andersen", "given": "Anne-Marie Nybo", "initials": "AN"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}], "type": "journal article", "published": "2021-10-17", "journal": {"title": "BJOG", "issn": "1471-0528", "issn-l": null}, "abstract": "To compare the risk of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and contact with specialist health-care services for coronavirus disease 2019 (COVID-19) between pregnant and non-pregnant women.\n\nAll women ages 15 to 45 living in Norway on March 1st , 2020 (N=1,033,699).\n\nWe linked information from the national birth, patient, communicable diseases, and education databases using unique national identifiers.\n\nWe estimated hazard ratios (HR) among pregnant compared to non-pregnant women of having a positive test for SARS-CoV-2, a diagnosis of COVID-19 in specialist healthcare, or hospitalization with COVID-19 using Cox regression. Multivariable analyses adjusted for age, marital status, education, income, country of birth and underlying medical conditions.\n\nPregnant women were not more likely to be tested for or to a have a positive SARS-CoV-2 test (adjusted HR, 0.99; 95% confidence interval [CI]: 0.92-1.07). Pregnant women had higher risk of hospitalization with COVID-19 (HR, 4.70; 95% CI: 3.51- 6.30), and any type of specialist care for COVID-19 (HR, 3.46; 95% CI: 2.89-4.14). Pregnant women born outside Scandinavia were less likely to be tested, and at higher risk of a positive test (HR, 2.37; 95% CI: 2.51-8.87). Compared to pregnant Scandinavian born women, pregnant women with minority background had a higher risk of hospitalization with COVID-19 (HR, 4.72; 95% CI: 2.51-8.87).\n\nPregnant women were not more likely to be infected with SARS-CoV-2. Still, pregnant women with COVID-19, especially those born outside of Scandinavia, were more likely to be hospitalized.", "doi": "10.1111/1471-0528.16969", "pmid": "34657368", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-21T05:02:48.784Z", "modified": "2021-10-21T05:02:48.838Z"}, {"entity": "publication", "iuid": "d68837621db0417dbb9ba64eeaebde42", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d68837621db0417dbb9ba64eeaebde42.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d68837621db0417dbb9ba64eeaebde42"}}, "title": "Cross-cultural prevalence of sleep quality and psychological distress in healthcare workers during COVID-19 pandemic.", "authors": [{"family": "Khan", "given": "Hamza Rafique", "initials": "HR", "orcid": "0000-0002-5914-1444", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd107a2d49c84125bd829a8e32a63af8.json"}}, {"family": "Ashraf", "given": "Farzana", "initials": "F", "orcid": "0000-0003-0110-2618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b5ea851706e4435a5a749b8f25b0147.json"}}, {"family": "Ullah", "given": "Irfan", "initials": "I", "orcid": "0000-0003-1100-101X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8d5a7e15ae6487cbdda0de3b2a531c3.json"}}, {"family": "Tahir", "given": "Muhammad Junaid", "initials": "MJ", "orcid": "0000-0002-0335-6681", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3192523e30b47e4ba6579ed8ab36661.json"}}, {"family": "Dominari", "given": "Asimina", "initials": "A", "orcid": "0000-0002-4023-9767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a082d5a6c7f64a0a982b53edcb22d2d1.json"}}, {"family": "Shoib", "given": "Sheikh", "initials": "S"}, {"family": "Naeem", "given": "Hamna", "initials": "H", "orcid": "0000-0002-3271-9250", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1dba9d91b94e487f84eec592237b73eb.json"}}, {"family": "Reddy", "given": "Gowry", "initials": "G", "orcid": "0000-0003-0774-5809", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5651795d3353483092a191cf52d094b3.json"}}, {"family": "Mukherjee", "given": "Pramit", "initials": "P", "orcid": "0000-0002-8717-2395", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a287ee82a04449d8d82230ad0c94fa0.json"}}, {"family": "Akram", "given": "Ifrah", "initials": "I", "orcid": "0000-0002-2737-3224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/983eaa0b255b454b946dda58b4786c04.json"}}, {"family": "Kamada", "given": "Sudha", "initials": "S", "orcid": "0000-0001-8332-8973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/095f77b1995148b5819f6a1c0e14acbb.json"}}, {"family": "Memon", "given": "Roshni Riaz", "initials": "RR", "orcid": "0000-0003-2410-2055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79c76ba9210341538cbcf2a5e0ef30b1.json"}}, {"family": "Khan", "given": "M Muzzamil Yasin", "initials": "MMY"}, {"family": "Raut", "given": "Sumit", "initials": "S", "orcid": "0000-0001-6090-8027", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9d431cfd57548979e61ff7287da4551.json"}}, {"family": "Shalaby", "given": "Mahmoud Mohamed Mohamed", "initials": "MMM", "orcid": "0000-0001-7237-4616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51ae61a95e0243438b5603032c6bc49b.json"}}, {"family": "Anwar", "given": "Rana Usman", "initials": "RU", "orcid": "0000-0002-7874-3870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2be3d1deeb044679da6f7738f399087.json"}}, {"family": "Farooq", "given": "Maheen", "initials": "M", "orcid": "0000-0001-5084-8614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c64e7d11516d400a91a9ee939f984b49.json"}}, {"family": "Soparia", "given": "Krupa Ketankumar", "initials": "KK", "orcid": "0000-0002-0711-5826", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae4d64ac01bc4241a25a27dd4c9dc77e.json"}}, {"family": "Ramalho", "given": "Rodrigo", "initials": "R", "orcid": "0000-0002-2372-6854", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b990d3c278047a9b3878d47316ea4ed.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-10-17", "journal": {"title": "Brain Behav", "issn": "2162-3279", "pages": "e2383", "issn-l": null}, "abstract": "Poor quality sleep and emotional disturbances are expected in times of crisis. COVID-19 has severely impacted healthcare worldwide and with that comes the concern about its effects on healthcare workers. The purpose of the present study was to assess sleep quality and psychological distress in healthcare workers during the COVID-19 pandemic.\n\nThe present work is a multi-centric cross-sectional study targeting healthcare workers from India, Pakistan, and Nepal. It used an online version of the Pittsburg Sleep Quality Index and the General Health Questionnaire, and data were analyzed using SPSS V.24.\n\nA total of 1790 participants completed the questionnaire. Of the 1790 participants, 57% reported poor sleep quality, and 10% reported a high level of psychological distress. A cross-cultural comparison found some differences between the different groups of participants. The details of the differences were further explored in the article.\n\nThe present study highlights that a significant proportion of healthcare workers are affected by poor sleep quality and psychological distress during the COVID-19 pandemic. It also emphasizes the imperative to provide them with psychosocial support to avoid potential short- and long-term psychological consequences of these troubling times.", "doi": "10.1002/brb3.2383", "pmid": "34661987", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-10-21T04:58:34.375Z", "modified": "2021-10-21T04:58:34.863Z"}, {"entity": "publication", "iuid": "ea26f82200d843c39406150be734c4b7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ea26f82200d843c39406150be734c4b7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ea26f82200d843c39406150be734c4b7"}}, "title": "Robotic-Based Well-Being Monitoring and Coaching System for the Elderly in Their Daily Activities", "authors": [{"family": "Calatrava-Nicol\u00e1s", "given": "Francisco M", "initials": "FM", "orcid": "0000-0001-6647-4215", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37ad41c6253a489c809900830c616348.json"}}, {"family": "Guti\u00e9rrez-Maestro", "given": "Eduardo", "initials": "E"}, {"family": "Bautista-Salinas", "given": "Daniel", "initials": "D", "orcid": "0000-0001-5318-952X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef0d6dafcd324c9eb0cad123179d7639.json"}}, {"family": "Ortiz", "given": "Francisco J", "initials": "FJ", "orcid": "0000-0002-2294-688X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10dde443cdb44d008b36eb5d1073d549.json"}}, {"family": "Gonz\u00e1lez", "given": "Joaqu\u00edn Roca", "initials": "JR"}, {"family": "Vera-Repullo", "given": "Jos\u00e9 Alfonso", "initials": "JA"}, {"family": "Jim\u00e9nez-Buend\u00eda", "given": "Manuel", "initials": "M", "orcid": "0000-0002-6092-1974", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67e238cdac5440b7936dba299312872c.json"}}, {"family": "M\u00e9ndez", "given": "Inmaculada", "initials": "I", "orcid": "0000-0001-8458-5314", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e971819fe8a447828199a0f987619383.json"}}, {"family": "Ruiz-Esteban", "given": "Cecilia", "initials": "C", "orcid": "0000-0002-5836-331X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae5cc8fc2ffe4cf384eab19408c21624.json"}}, {"family": "Mozos", "given": "Oscar Mart\u00ednez", "initials": "OM"}], "type": "journal-article", "published": "2021-10-16", "journal": {"title": "Sensors (Basel)", "issn": "1424-8220", "issn-l": null, "volume": "21", "issue": "20", "pages": "6865"}, "abstract": null, "doi": "10.3390/s21206865", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:29:19.094Z", "modified": "2022-02-17T11:44:28.465Z"}, {"entity": "publication", "iuid": "b96c3e80cf1140bc8be296eb4d99e995", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b96c3e80cf1140bc8be296eb4d99e995.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b96c3e80cf1140bc8be296eb4d99e995"}}, "title": "Correspondence regarding \"Delay to elective colorectal cancer surgery and implications for survival: a systematic review and meta-analysis\".", "authors": [{"family": "Onerup", "given": "Aron", "initials": "A"}, {"family": "Rydbeck", "given": "Daniel", "initials": "D"}, {"family": "Bock", "given": "David", "initials": "D"}, {"family": "Haglind", "given": "Eva", "initials": "E"}, {"family": "Angenete", "given": "Eva", "initials": "E", "orcid": "0000-0001-9966-4904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/473b9940a9f34e379796200d3769cbf6.json"}}], "type": "letter", "published": "2021-10-16", "journal": {"title": "Colorectal Dis", "issn": "1463-1318", "issn-l": null}, "abstract": "We read with interest the article by Whittaker et al [1]. We believe that the research question is of importance both in light of delayed treatment during the COVID-19 pandemic and in light of recent results where preoperative lifestyle changes only seem to be effective when performed for at least six weeks [2, 3]. However, we have some questions regarding the methodology and conclusions from the study.", "doi": "10.1111/codi.15957", "pmid": "34655446", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-21T05:04:00.437Z", "modified": "2021-10-21T05:04:00.515Z"}, {"entity": "publication", "iuid": "c02bff9bce9740ffb1887af7a9a305ec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c02bff9bce9740ffb1887af7a9a305ec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c02bff9bce9740ffb1887af7a9a305ec"}}, "title": "Bacterial contamination of the smartphones of healthcare workers in a German tertiary-care hospital before and during the COVID-19 pandemic.", "authors": [{"family": "Tannh\u00e4user", "given": "Romy", "initials": "R"}, {"family": "Nickel", "given": "Olaf", "initials": "O"}, {"family": "Lindner", "given": "Margareta", "initials": "M"}, {"family": "Bethge", "given": "Angela", "initials": "A"}, {"family": "Wolf", "given": "Johannes", "initials": "J"}, {"family": "Borte", "given": "Stephan", "initials": "S"}, {"family": "L\u00fcbbert", "given": "Christoph", "initials": "C"}], "type": "journal article", "published": "2021-10-16", "journal": {"title": "Am J Infect Control", "issn": "1527-3296", "issn-l": null}, "abstract": "Assuming that hygiene measures have improved significantly due to COVID-19, we aimed to investigate bacterial colonization on smartphones (SPs) owned by healthcare workers (HCWs) before and during the pandemic.\n\nEmploying a before-and-after study design, randomly selected HCWs were included. Devices underwent sampling under real-life conditions, without prior manipulation. Swabs were collected in 2012 (pre-pandemic) and 2021 to determine microbial colonization. Isolates were identified by MALDI-TOF mass spectrometry and underwent microbiological susceptibility testing.\n\nThe final analysis included 295 HCWs (67% female, mean age 34 years) from 26 wards. Bacterial contamination was present on 293 of 295 SP screens (99.3%). The proportion of clinically relevant bacterial pathogens (e.g. Staphylococcus aureus, enterococci, Enterobacterales, non-fermenting bacteria) ranged from 21.2% in 2012 to 39.8% in 2021. Resistance profiles revealed a proportion of multidrug-resistant bacteria such as MRSA and VRE of less than 2%. The comparison of before-and-after sampling showed a significant increase in smartphone use during work from 2012 to 2021 with a simultaneous increase in cleaning intensity, probably as a result of the COVID-19 pandemic.\n\nBacterial contamination of SPs within the hospital is of concern and can serve as a source of cross-contamination. Hence, SPs must be carefully disinfected after handling in healthcare. Behavioral changes related to the COVID-19 pandemic could have a significant impact if implemented sustainably in everyday clinical practice.", "doi": "10.1016/j.ajic.2021.09.025", "pmid": "34666129", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0196-6553(21)00669-6"}], "notes": [], "created": "2021-10-21T04:50:10.433Z", "modified": "2021-10-21T04:50:10.470Z"}, {"entity": "publication", "iuid": "fda0d68c9682442b9ea60df82cad31e6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fda0d68c9682442b9ea60df82cad31e6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fda0d68c9682442b9ea60df82cad31e6"}}, "title": "Self-reported impact of the COVID-19 pandemic, affective responding, and subjective well-being: A Swedish survey.", "authors": [{"family": "Gr\u00f6ndal", "given": "Maria", "initials": "M", "orcid": "0000-0002-1108-249X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/710a6d6cf4de46eb9ae1b2e4837dc67c.json"}}, {"family": "Ask", "given": "Karl", "initials": "K", "orcid": "0000-0001-5093-5902", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec311e51b22d445f98839bf046ab4637.json"}}, {"family": "Luke", "given": "Timothy J", "initials": "TJ", "orcid": "0000-0002-5513-6605", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d790d0984ed42b6afa6f8649e74e836.json"}}, {"family": "Winblad", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2021-10-15", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0258778", "issn-l": "1932-6203"}, "abstract": "A rapid stream of research confirms that the COVID-19 pandemic is a global threat to mental health and psychological well-being. It is therefore important to identify both hazardous and protective individual factors during the pandemic. The current research explored the relationships between self-reported affective responding, perceived personal consequences of the COVID-19 pandemic, and subjective well-being. An online survey (N = 471) conducted in Sweden between June and September, 2020, showed that higher levels of irritability, impulsivity, and the tendency to experience and express anger were generally associated with more severe personal consequences of the pandemic, particularly in areas related to family life, work/study, and finances. While more severe impacts of the pandemic in these areas of life were directly associated with lower subjective well-being, emotion regulation through cognitive reappraisal appeared to moderate the extent to which consequences of the pandemic in other areas of life (i.e., social, free-time and physical activities) translated into decreased well-being. This suggests that cognitive reappraisal may serve to protect against some of the debilitating effects of the COVID-19 pandemic on mental health. Overall, the results indicate that the perceived consequences of the pandemic are multifaceted and that future research should examine these consequences using a multidimensional approach.", "doi": "10.1371/journal.pone.0258778", "pmid": "34653222", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-05122"}], "notes": [], "created": "2021-10-21T05:04:57.088Z", "modified": "2021-10-21T05:04:57.216Z"}, {"entity": "publication", "iuid": "16f513d95162469b87c66881775a8960", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16f513d95162469b87c66881775a8960.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16f513d95162469b87c66881775a8960"}}, "title": "Results of the COVID-19 mental health international for the general population (COMET-G) study.", "authors": [{"family": "Fountoulakis", "given": "Konstantinos N", "initials": "KN"}, {"family": "Karakatsoulis", "given": "Grigorios", "initials": "G"}, {"family": "Abraham", "given": "Seri", "initials": "S"}, {"family": "Adorjan", "given": "Kristina", "initials": "K"}, {"family": "Ahmed", "given": "Helal Uddin", "initials": "HU"}, {"family": "Alarc\u00f3n", "given": "Renato D", "initials": "RD"}, {"family": "Arai", "given": "Kiyomi", "initials": "K"}, {"family": "Auwal", "given": "Sani Salihu", "initials": "SS"}, {"family": "Berk", "given": "Michael", "initials": "M"}, {"family": "Bjedov", "given": "Sarah", "initials": "S"}, {"family": "Bobes", "given": "Julio", "initials": "J"}, {"family": "Bobes-Bascaran", "given": "Teresa", "initials": "T"}, {"family": "Bourgin-Duchesnay", "given": "Julie", "initials": "J"}, {"family": "Bredicean", "given": "Cristina Ana", "initials": "CA"}, {"family": "Bukelskis", "given": "Laurynas", "initials": "L"}, {"family": "Burkadze", "given": "Akaki", "initials": "A"}, {"family": "Abud", "given": "Indira Indiana Cabrera", "initials": "IIC"}, {"family": "Castilla-Puentes", "given": "Ruby", "initials": "R"}, {"family": "Cetkovich", "given": "Marcelo", "initials": "M"}, {"family": "Colon-Rivera", "given": "Hector", "initials": "H"}, {"family": "Corral", "given": "Ricardo", "initials": "R"}, {"family": "Cortez-Vergara", "given": "Carla", "initials": "C"}, {"family": "Crepin", "given": "Piirika", "initials": "P"}, {"family": "De Berardis", "given": "Domenico", "initials": "D"}, {"family": "Zamora Delgado", "given": "Sergio", "initials": "S"}, {"family": "De Lucena", "given": "David", "initials": "D"}, {"family": "De Sousa", "given": "Avinash", "initials": "A"}, {"family": "Stefano", "given": "Ramona Di", "initials": "RD"}, {"family": "Dodd", "given": "Seetal", "initials": "S"}, {"family": "Elek", "given": "Livia Priyanka", "initials": "LP"}, {"family": "Elissa", "given": "Anna", "initials": "A"}, {"family": "Erdelyi-Hamza", "given": "Berta", "initials": "B"}, {"family": "Erzin", "given": "Gamze", "initials": "G"}, {"family": "Etchevers", "given": "Martin J", "initials": "MJ"}, {"family": "Falkai", "given": "Peter", "initials": "P"}, {"family": "Farcas", "given": "Adriana", "initials": "A"}, {"family": "Fedotov", "given": "Ilya", "initials": "I"}, {"family": "Filatova", "given": "Viktoriia", "initials": "V"}, {"family": "Fountoulakis", "given": "Nikolaos K", "initials": "NK"}, {"family": "Frankova", "given": "Iryna", "initials": "I"}, {"family": "Franza", "given": "Francesco", "initials": "F"}, {"family": "Frias", "given": "Pedro", "initials": "P"}, {"family": "Galako", "given": "Tatiana", "initials": "T"}, {"family": "Garay", "given": "Cristian J", "initials": "CJ"}, {"family": "Garcia-\u00c1lvarez", "given": "Leticia", "initials": "L"}, {"family": "Garc\u00eda-Portilla", "given": "Maria Paz", "initials": "MP"}, {"family": "Gonda", "given": "Xenia", "initials": "X"}, {"family": "Gondek", "given": "Tomasz M", "initials": "TM"}, {"family": "Gonz\u00e1lez", "given": "Daniela Morera", "initials": "DM"}, {"family": "Gould", "given": "Hilary", "initials": "H"}, {"family": "Grandinetti", "given": "Paolo", "initials": "P"}, {"family": "Grau", "given": "Arturo", "initials": "A"}, {"family": "Groudeva", "given": "Violeta", "initials": "V"}, {"family": "Hagin", "given": "Michal", "initials": "M"}, {"family": "Harada", "given": "Takayuki", "initials": "T"}, {"family": "Hasan", "given": "Tasdik M", "initials": "TM"}, {"family": "Hashim", "given": "Nurul Azreen", "initials": "NA"}, {"family": "Hilbig", "given": "Jan", "initials": "J"}, {"family": "Hossain", "given": "Sahadat", "initials": "S"}, {"family": "Iakimova", "given": "Rossitza", "initials": "R"}, {"family": "Ibrahim", "given": "Mona", "initials": "M"}, {"family": "Iftene", "given": "Felicia", "initials": "F"}, {"family": "Ignatenko", "given": "Yulia", "initials": "Y"}, {"family": "Irarrazaval", "given": "Matias", "initials": "M"}, {"family": "Ismail", "given": "Zaliha", "initials": "Z"}, {"family": "Ismayilova", "given": "Jamila", "initials": "J"}, {"family": "Jakobs", "given": "Asaf", "initials": "A"}, {"family": "Jakovljevi\u0107", "given": "Miro", "initials": "M"}, {"family": "Jak\u0161i\u0107", "given": "Nenad", "initials": "N"}, {"family": "Javed", "given": "Afzal", "initials": "A"}, {"family": "Kafali", "given": "Helin Yilmaz", "initials": "HY"}, {"family": "Karia", "given": "Sagar", "initials": "S"}, {"family": "Kazakova", "given": "Olga", "initials": "O"}, {"family": "Khalifa", "given": "Doaa", "initials": "D"}, {"family": "Khaustova", "given": "Olena", "initials": "O"}, {"family": "Koh", "given": "Steve", "initials": "S"}, {"family": "Kopishinskaia", "given": "Svetlana", "initials": "S"}, {"family": "Kosenko", "given": "Korneliia", "initials": "K"}, {"family": "Koupidis", "given": "Sotirios A", "initials": "SA"}, {"family": "Kovacs", "given": "Illes", "initials": "I"}, {"family": "Kulig", "given": "Barbara", "initials": "B"}, {"family": "Lalljee", "given": "Alisha", "initials": "A"}, {"family": "Liewig", "given": "Justine", "initials": "J"}, {"family": "Majid", "given": "Abdul", "initials": "A"}, {"family": "Malashonkova", "given": "Evgeniia", "initials": "E"}, {"family": "Malik", "given": "Khamelia", "initials": "K"}, {"family": "Malik", "given": "Najma Iqbal", "initials": "NI"}, {"family": "Mammadzada", "given": "Gulay", "initials": "G"}, {"family": "Mandalia", "given": "Bilvesh", "initials": "B"}, {"family": "Marazziti", "given": "Donatella", "initials": "D"}, {"family": "Mar\u010dinko", "given": "Darko", "initials": "D"}, {"family": "Martinez", "given": "Stephanie", "initials": "S"}, {"family": "Matiekus", "given": "Eimantas", "initials": "E"}, {"family": "Mejia", "given": "Gabriela", "initials": "G"}, {"family": "Memon", "given": "Roha Saeed", "initials": "RS"}, {"family": "Mart\u00ednez", "given": "Xarah Elenne Meza", "initials": "XEM"}, {"family": "Mickevi\u010di\u016bt\u0117", "given": "Dalia", "initials": "D"}, {"family": "Milev", "given": "Roumen", "initials": "R"}, {"family": "Mohammed", "given": "Muftau", "initials": "M"}, {"family": "Molina-L\u00f3pez", "given": "Alejandro", "initials": "A"}, {"family": "Morozov", "given": "Petr", "initials": "P"}, {"family": "Muhammad", "given": "Nuru Suleiman", "initials": "NS"}, {"family": "Musta\u010d", "given": "Filip", "initials": "F"}, {"family": "Naor", "given": "Mika S", "initials": "MS"}, {"family": "Nassieb", "given": "Amira", "initials": "A"}, {"family": "Navickas", "given": "Alvydas", "initials": "A"}, {"family": "Okasha", "given": "Tarek", "initials": "T"}, {"family": "Pandova", "given": "Milena", "initials": "M"}, {"family": "Panfil", "given": "Anca-Livia", "initials": "AL"}, {"family": "Panteleeva", "given": "Liliya", "initials": "L"}, {"family": "Papava", "given": "Ion", "initials": "I"}, {"family": "Patsali", "given": "Mikaella E", "initials": "ME"}, {"family": "Pavlichenko", "given": "Alexey", "initials": "A"}, {"family": "Pejuskovic", "given": "Bojana", "initials": "B"}, {"family": "Pinto Da Costa", "given": "Mariana", "initials": "M"}, {"family": "Popkov", "given": "Mikhail", "initials": "M"}, {"family": "Popovic", "given": "Dina", "initials": "D"}, {"family": "Raduan", "given": "Nor Jannah Nasution", "initials": "NJN"}, {"family": "Ram\u00edrez", "given": "Francisca Vargas", "initials": "FV"}, {"family": "Rancans", "given": "Elmars", "initials": "E"}, {"family": "Razali", "given": "Salmi", "initials": "S"}, {"family": "Rebok", "given": "Federico", "initials": "F"}, {"family": "Rewekant", "given": "Anna", "initials": "A"}, {"family": "Flores", "given": "Elena Ninoska Reyes", "initials": "ENR"}, {"family": "Rivera-Encinas", "given": "Mar\u00eda Teresa", "initials": "MT"}, {"family": "Saiz", "given": "Pilar", "initials": "P"}, {"family": "de Carmona", "given": "Manuel S\u00e1nchez", "initials": "MS"}, {"family": "Mart\u00ednez", "given": "David Saucedo", "initials": "DS"}, {"family": "Saw", "given": "Jo Anne", "initials": "JA"}, {"family": "Saygili", "given": "G\u00f6rkem", "initials": "G"}, {"family": "Schneidereit", "given": "Patricia", "initials": "P"}, {"family": "Shah", "given": "Bhumika", "initials": "B"}, {"family": "Shirasaka", "given": "Tomohiro", "initials": "T"}, {"family": "Silagadze", "given": "Ketevan", "initials": "K"}, {"family": "Sitanggang", "given": "Satti", "initials": "S"}, {"family": "Skugarevsky", "given": "Oleg", "initials": "O"}, {"family": "Spikina", "given": "Anna", "initials": "A"}, {"family": "Mahalingappa", "given": "Sridevi Sira", "initials": "SS"}, {"family": "Stoyanova", "given": "Maria", "initials": "M"}, {"family": "Szczegielniak", "given": "Anna", "initials": "A"}, {"family": "Tamasan", "given": "Simona Claudia", "initials": "SC"}, {"family": "Tavormina", "given": "Giuseppe", "initials": "G"}, {"family": "Tavormina", "given": "Maurilio Giuseppe Maria", "initials": "MGM"}, {"family": "Theodorakis", "given": "Pavlos N", "initials": "PN"}, {"family": "Tohen", "given": "Mauricio", "initials": "M"}, {"family": "Tsapakis", "given": "Eva Maria", "initials": "EM"}, {"family": "Tukhvatullina", "given": "Dina", "initials": "D"}, {"family": "Ullah", "given": "Irfan", "initials": "I"}, {"family": "Vaidya", "given": "Ratnaraj", "initials": "R"}, {"family": "Vega-Dienstmaier", "given": "Johann M", "initials": "JM"}, {"family": "Vrublevska", "given": "Jelena", "initials": "J"}, {"family": "Vukovic", "given": "Olivera", "initials": "O"}, {"family": "Vysotska", "given": "Olga", "initials": "O"}, {"family": "Widiasih", "given": "Natalia", "initials": "N"}, {"family": "Yashikhina", "given": "Anna", "initials": "A"}, {"family": "Prezerakos", "given": "Panagiotis E", "initials": "PE"}, {"family": "Smirnova", "given": "Daria", "initials": "D"}], "type": "journal article", "published": "2021-10-15", "journal": {"title": "Eur Neuropsychopharmacol", "issn": "1873-7862", "volume": "54", "pages": "21-40", "issn-l": null}, "abstract": "There are few published empirical data on the effects of COVID-19 on mental health, and until now, there is no large international study.\n\nDuring the COVID-19 pandemic, an online questionnaire gathered data from 55,589 participants from 40 countries (64.85% females aged 35.80 \u00b1 13.61; 34.05% males aged 34.90\u00b113.29 and 1.10% other aged 31.64\u00b113.15). Distress and probable depression were identified with the use of a previously developed cut-off and algorithm respectively.\n\nDescriptive statistics were calculated. Chi-square tests, multiple forward stepwise linear regression analyses and Factorial Analysis of Variance (ANOVA) tested relations among variables.\n\nProbable depression was detected in 17.80% and distress in 16.71%. A significant percentage reported a deterioration in mental state, family dynamics and everyday lifestyle. Persons with a history of mental disorders had higher rates of current depression (31.82% vs. 13.07%). At least half of participants were accepting (at least to a moderate degree) a non-bizarre conspiracy. The highest Relative Risk (RR) to develop depression was associated with history of Bipolar disorder and self-harm/attempts (RR = 5.88). Suicidality was not increased in persons without a history of any mental disorder. Based on these results a model was developed.\n\nThe final model revealed multiple vulnerabilities and an interplay leading from simple anxiety to probable depression and suicidality through distress. This could be of practical utility since many of these factors are modifiable. Future research and interventions should specifically focus on them.", "doi": "10.1016/j.euroneuro.2021.10.004", "pmid": "34758422", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0924-977X(21)00775-6"}, {"db": "pmc", "key": "PMC8609892"}], "notes": [], "created": "2021-11-26T15:22:18.414Z", "modified": "2021-11-26T15:22:18.427Z"}, {"entity": "publication", "iuid": "a8685649f67047399e5093949f457284", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8685649f67047399e5093949f457284.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8685649f67047399e5093949f457284"}}, "title": "Psychometric Testing of the Modified Dental Anxiety Scale among Iranian Adolescents during COVID-19 Pandemic", "authors": [{"family": "Lin", "given": "Chung Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": 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"https://publications-covid19.scilifelab.se/researcher/301b59d7b5074ace866319c0210d60ac.json"}}, {"family": "Tascini", "given": "Carlo", "initials": "C", "orcid": "0000-0001-9625-6024", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ea9384b56c654e5ebec3000ee2c4e285.json"}}, {"family": "Miranda-Castillo", "given": "Carolina", "initials": "C", "orcid": "0000-0001-8763-9576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8152e4ccbe9146ab96382e954909b55d.json"}}, {"family": "Khanna", "given": "Nina", "initials": "N", "orcid": "0000-0002-2642-419X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4ea8c9224c44ead9bcf5360e0412cd4.json"}}, {"family": "M\u00e9ndez", "given": "Gustavo-Adolfo", "initials": "GA", "orcid": "0000-0003-0514-7004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed5e3f5f20fd4a40b5780d14663ac211.json"}}, {"family": "Petzer", "given": "Verena", "initials": "V", "orcid": "0000-0002-9205-1440", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b52c652fbe2245d1a3df0ca220d8ad98.json"}}, {"family": "Nov\u00e1k", "given": "Jan", "initials": "J"}, {"family": "Besson", "given": "Caroline", "initials": "C", "orcid": "0000-0003-4364-7173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/adc322a60efe4963a3ff76aa00c885d6.json"}}, {"family": "Dul\u00e9ry", "given": "R\u00e9my", "initials": "R", "orcid": "0000-0002-5024-1713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e911a2d994434edbb736f77b7ccfcd72.json"}}, {"family": "Lamure", "given": "Sylvain", "initials": "S", "orcid": "0000-0001-5980-305X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0dc734a9a9e4016b2a1699809823fe2.json"}}, {"family": "Nucci", "given": "Marcio", "initials": "M", "orcid": "0000-0003-4867-0014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/abfb43328b9e49f5bb8a68af1dea23a9.json"}}, {"family": "Zambrotta", "given": "Giovanni", "initials": "G", "orcid": "0000-0002-8612-2994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa7e3e475561489d8a588f32256d8789.json"}}, {"family": "\u017d\u00e1k", "given": "Pavel", "initials": "P", "orcid": "0000-0003-4465-5343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/575505da6a594afd909f7d23ee161067.json"}}, {"family": "Seval", "given": "Guldane Cengiz", "initials": "GC", "orcid": "0000-0001-9433-2054", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e3b8c93389cf44fbabefe0d826d98f90.json"}}, {"family": "Bonuomo", "given": "Valentina", "initials": "V", "orcid": "0000-0001-6491-8337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/71cfcc19d793475898e9a4e94d9ba5ba.json"}}, {"family": "Mayer", "given": "Ji\u0159\u00ed", "initials": "J", "orcid": "0000-0003-0567-9887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af07e6256c3c4aa086315372fdbbc25c.json"}}, {"family": "L\u00f3pez-Garc\u00eda", "given": "Alberto", "initials": "A", "orcid": "0000-0002-5354-5261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c785356a67e4cbb9835fe9ce04a6153.json"}}, {"family": "Sacchi", "given": "Maria Vittoria", "initials": "MV", "orcid": "0000-0001-8133-3357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62e9765439304851b3d996f5a4ce6603.json"}}, {"family": "Booth", "given": "Stephen", "initials": "S", "orcid": "0000-0003-2687-0234", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d01b042ad524b7f8f5e6ac4486c2121.json"}}, {"family": "Ciceri", "given": "Fabio", "initials": "F", "orcid": "0000-0003-0873-0123", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/409a23f2dc8143a18aba6f8b91e597c7.json"}}, {"family": "Oberti", "given": "Margherita", "initials": "M"}, {"family": "Salvini", "given": "Marco", "initials": "M"}, {"family": "Izuzquiza", "given": "Macarena", "initials": "M"}, {"family": "Nunes-Rodrigues", "given": "Raquel", "initials": "R", "orcid": "0000-0002-8347-4281", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59fe3851cbd1404395c359435a99edbf.json"}}, {"family": "Ammatuna", "given": "Emanuele", "initials": "E", "orcid": "0000-0001-8247-4901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5904d1457399478aaaba50bcc584d502.json"}}, {"family": "Obr", "given": "Ale\u0161", "initials": "A", "orcid": "0000-0002-6758-3074", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35684b424cde4350a32f7ea16e0c9093.json"}}, {"family": "Herbrecht", "given": "Raoul", "initials": "R", "orcid": "0000-0002-9381-4876", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d015f48d57ac4543b0d5a5965582f46e.json"}}, {"family": "N\u00fa\u00f1ez-Mart\u00edn-Buitrago", "given": "Luc\u00eda", "initials": "L"}, {"family": "Mancini", "given": "Valentina", "initials": "V"}, {"family": "Shwaylia", "given": "Hawraa", "initials": "H", "orcid": "0000-0002-4098-6092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd1fea4026e941a98fa7c6f7a084bdb6.json"}}, {"family": "Scium\u00e8", "given": "Mariarita", "initials": "M", "orcid": "0000-0001-7958-4966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f9857d37d7041a3ae43ee186a3d0629.json"}}, {"family": "Essame", "given": "Jenna", "initials": "J", "orcid": "0000-0003-0926-5577", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e742441946aa4011877daa743e29be52.json"}}, {"family": "Nygaard", "given": "Marietta", "initials": "M"}, {"family": "Batini\u0107", "given": "Josip", "initials": "J", "orcid": "0000-0001-5595-9911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d11d10189d71468e9e606ab7b428327c.json"}}, {"family": "Gonzaga", "given": "Yung", "initials": "Y", "orcid": "0000-0003-1416-2118", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0ff6be47e1ad4b729cdc6d4648073464.json"}}, {"family": "Regalado-Artamendi", "given": "Isabel", "initials": "I", "orcid": "0000-0002-9673-9015", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4527d7987ea449ff9a3d6e3135c54018.json"}}, {"family": "Karlsson", "given": "Linda Katharina", "initials": "LK", "orcid": "0000-0003-3317-7550", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7755dec3898c4e33a5729825a8d2dacd.json"}}, {"family": "Shapetska", "given": "Maryia", "initials": "M", "orcid": "0000-0002-1223-9161", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87e2b1bfa19d48d5892330aa3114c9ba.json"}}, {"family": "Hanakova", "given": "Michaela", "initials": "M"}, {"family": "El-Ashwah", "given": "Shaimaa", "initials": "S", "orcid": "0000-0003-2210-1534", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46dc0125ae354da09dddd0ffd083d199.json"}}, {"family": "Borb\u00e9nyi", "given": "Zita", "initials": "Z"}, {"family": "\u00c7olak", "given": "G\u00f6k\u00e7e Melis", "initials": "GM", "orcid": "0000-0002-7662-7454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42d2006ada9e473db89249bc882d6083.json"}}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Dragonetti", "given": "Giulia", "initials": "G", "orcid": "0000-0003-1775-6333", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81694822ac4d4074bfabe757d03f5f9e.json"}}, {"family": "Maraglino", "given": "Alessio Maria Edoardo", "initials": "AME"}, {"family": "Rinaldi", "given": "Amelia", "initials": "A", "orcid": "0000-0002-8211-5076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/689f30c83b4e4da7a48d853abd22d6e5.json"}}, {"family": "De Ram\u00f3n-S\u00e1nchez", "given": "Cristina", "initials": "C", "orcid": "0000-0002-8167-6410", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d42267ab742491d95080c6592197d6a.json"}}, {"family": "Cornely", "given": "Oliver A", "initials": "OA", "orcid": "0000-0001-9599-3137", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3c62d8346924e69b6c99e4007c3831c.json"}}, {"family": "EPICOVIDEHA working group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-10-14", "journal": {"title": "J Hematol Oncol", "issn": "1756-8722", "volume": "14", "issue": "1", "pages": "168", "issn-l": null}, "abstract": "Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics of HM patients developing COVID-19 and analyzed predictors of mortality.\n\nThe survey was supported by the Scientific Working Group Infection in Hematology of the European Hematology Association (EHA). Eligible for the analysis were adult patients with HM and laboratory-confirmed COVID-19 observed between March and December 2020.\n\nThe study sample includes 3801 cases, represented by lymphoproliferative (mainly non-Hodgkin lymphoma n = 1084, myeloma n = 684 and chronic lymphoid leukemia n = 474) and myeloproliferative malignancies (mainly acute myeloid leukemia n = 497 and myelodysplastic syndromes n = 279). Severe/critical COVID-19 was observed in 63.8% of patients (n = 2425). Overall, 2778 (73.1%) of the patients were hospitalized, 689 (18.1%) of whom were admitted to intensive care units (ICUs). Overall, 1185 patients (31.2%) died. The primary cause of death was COVID-19 in 688 patients (58.1%), HM in 173 patients (14.6%), and a combination of both COVID-19 and progressing HM in 155 patients (13.1%). Highest mortality was observed in acute myeloid leukemia (199/497, 40%) and myelodysplastic syndromes (118/279, 42.3%). The mortality rate significantly decreased between the first COVID-19 wave (March-May 2020) and the second wave (October-December 2020) (581/1427, 40.7% vs. 439/1773, 24.8%, p value < 0.0001). In the multivariable analysis, age, active malignancy, chronic cardiac disease, liver disease, renal impairment, smoking history, and ICU stay correlated with mortality. Acute myeloid leukemia was a higher mortality risk than lymphoproliferative diseases.\n\nThis survey confirms that COVID-19 patients with HM are at high risk of lethal complications. However, improved COVID-19 prevention has reduced mortality despite an increase in the number of reported cases.", "doi": "10.1186/s13045-021-01177-0", "pmid": "34649563", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13045-021-01177-0"}], "notes": [], "created": "2021-10-21T05:05:31.090Z", "modified": "2021-10-21T05:05:33.687Z"}, {"entity": "publication", "iuid": "63244c74094741c59119d7f7977b6905", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63244c74094741c59119d7f7977b6905.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63244c74094741c59119d7f7977b6905"}}, "title": "A Spatial Analysis of COVID-19 in African Countries: Evaluating the Effects of Socio-Economic Vulnerabilities and Neighbouring.", "authors": [{"family": "Manda", "given": "Samuel O M", "initials": "SOM", "orcid": "0000-0002-9672-3312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b073c7d0b3d40e5acc15d6be304fd24.json"}}, {"family": "Darikwa", "given": "Timotheus", "initials": "T", "orcid": "0000-0002-6555-3154", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e75f35ad6d94666a549b45c65f038ca.json"}}, {"family": "Nkwenika", "given": "Tshifhiwa", "initials": "T"}, {"family": "Bergquist", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2021-10-14", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "20", "issn-l": null}, "abstract": "The ongoing highly contagious coronavirus disease 2019 (COVID-19) pandemic, which started in Wuhan, China, in December 2019, has now become a global public health problem. Using publicly available data from the COVID-19 data repository of Our World in Data, we aimed to investigate the influences of spatial socio-economic vulnerabilities and neighbourliness on the COVID-19 burden in African countries. We analyzed the first wave (January-September 2020) and second wave (October 2020 to May 2021) of the COVID-19 pandemic using spatial statistics regression models. As of 31 May 2021, there was a total of 4,748,948 confirmed COVID-19 cases, with an average, median, and range per country of 101,041, 26,963, and 2191 to 1,665,617, respectively. We found that COVID-19 prevalence in an Africa country was highly dependent on those of neighbouring Africa countries as well as its economic wealth, transparency, and proportion of the population aged 65 or older (p-value < 0.05). Our finding regarding the high COVID-19 burden in countries with better transparency and higher economic wealth is surprising and counterintuitive. We believe this is a reflection on the differences in COVID-19 testing capacity, which is mostly higher in more developed countries, or data modification by less transparent governments. Country-wide integrated COVID suppression strategies such as limiting human mobility from more urbanized to less urbanized countries, as well as an understanding of a county's social-economic characteristics, could prepare a country to promptly and effectively respond to future outbreaks of highly contagious viral infections such as COVID-19.", "doi": "10.3390/ijerph182010783", "pmid": "34682528", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph182010783"}], "notes": [], "created": "2021-10-26T18:15:49.424Z", "modified": "2021-10-26T18:15:49.522Z"}, {"entity": "publication", "iuid": "872d89e3d1164efeb1fb997c306b26c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/872d89e3d1164efeb1fb997c306b26c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/872d89e3d1164efeb1fb997c306b26c0"}}, "title": "A Longitudinal Study of Gambling Behaviors During the COVID-19 Pandemic in Sweden.", "authors": [{"family": "M\u00e5nsson", "given": "Viktor", "initials": "V"}, {"family": "Wall", "given": "H\u00e5kan", "initials": "H"}, {"family": "Berman", "given": "Anne H", "initials": "AH"}, {"family": "Jayaram-Lindstr\u00f6m", "given": "Nitya", "initials": "N"}, {"family": "Rosendahl", "given": "Ingvar", "initials": "I"}], "type": "journal article", "published": "2021-10-14", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "708037", "issn-l": "1664-1078"}, "abstract": "This study aimed to investigate changes in gambling behaviors during the first and second waves of the COVID-19 pandemic in Sweden. Participants who had gambled within the past year were recruited from social media and the Swedish National Helpline (n = 325, mean age 39.8 years, 64.8% males, 31.3% with problem gambling) and completed an online survey measuring gambling behaviors, consequences of the pandemic in general and worries related to the pandemic. A sub-sample (n = 139) completed a follow-up survey, during the second wave. The results showed no significant associations between COVID-19 consequences (financial or increased isolation) and increased monthly gambling behavior. No major migrations were observed between game types. However, gambling on a high-risk game (OR = 7.44, p < 0.001) and worrying about mental health due to the pandemic (OR = 2.85, p < 0.001) were significantly associated with past year gambling problems and increased monthly gambling problems from the first to the second wave. More longitudinal research is needed in vulnerable populations, to fully understand the long-term consequences of the pandemic.", "doi": "10.3389/fpsyg.2021.708037", "pmid": "34721154", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8552012"}], "notes": [], "created": "2021-11-02T15:31:07.371Z", "modified": "2023-06-19T14:25:06.196Z"}, {"entity": "publication", "iuid": "59a5b39a1bad4ee2b05041ad5334f949", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/59a5b39a1bad4ee2b05041ad5334f949.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/59a5b39a1bad4ee2b05041ad5334f949"}}, "title": "The effects of a physical and cognitive training intervention vs. physical training alone on older adults' physical activity: A randomized controlled trial with extended follow-up during COVID-19.", "authors": [{"family": "Savikangas", "given": "Tiina", "initials": "T", "orcid": "0000-0002-8367-4304", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00e78fc921a64887bbb3accdba9da9fc.json"}}, {"family": "T\u00f6rm\u00e4kangas", "given": "Timo", "initials": "T"}, {"family": "Tirkkonen", "given": "Anna", "initials": "A"}, {"family": "Alen", "given": "Markku", "initials": "M"}, {"family": "Fielding", "given": "Roger A", "initials": "RA"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Rantalainen", "given": "Timo", "initials": "T"}, {"family": "Stigsdotter Neely", "given": "Anna", "initials": "A"}, {"family": "Sipil\u00e4", "given": "Sarianna", "initials": "S"}], "type": "journal article", "published": "2021-10-13", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0258559", "issn-l": "1932-6203"}, "abstract": "Executive functions underlie self-regulation and are thus important for physical activity and adaptation to new situations. The aim was to investigate, if yearlong physical and cognitive training (PTCT) had greater effects on physical activity among older adults than physical training (PT) alone, and if executive functions predicted physical activity at baseline, after six (6m) and twelve months (12m) of the interventions, one-year post-intervention follow-up and an extended follow-up during COVID-19 lockdown.\n\nData from a single-blinded, parallel-group randomized controlled trial (PASSWORD-study, ISRCTN52388040) were utilized. Participants were 70-85 years old community-dwelling men and women from Jyv\u00e4skyl\u00e4, Finland. PT (n = 159) included supervised resistance, walking and balance training, home-exercises and self-administered moderate activity. PTCT (n = 155) included PT and cognitive training targeting executive functions on a computer program. Physical activity was assessed with a one-item, seven-scale question. Executive functions were assessed with color-word Stroop, Trail Making Test (TMT) B-A and Letter Fluency. Changes in physical activity were modeled with multinomial logistic models and the impact of executive functions on physical activity with latent change score models.\n\nNo significant group-by-time interaction was observed for physical activity (p>0.1). The subjects were likely to select an activity category higher than baseline throughout the study (pooled data: B = 0.720-1.614, p<0.001-0.046). Higher baseline Stroop predicted higher physical activity through all subsequent time-points (pooled data: B = 0.011-0.013, p = 0.015-0.030). Higher baseline TMT B-A predicted higher physical activity at 6m (pooled data: B = 0.007, p = 0.006) and during COVID-19 (B = 0.005, p = 0.030). In the PT group, higher baseline Letter Fluency predicted higher physical activity at 12m (B = -0.028, p = 0.030) and follow-up (B = -0.042, p = 0.002).\n\nCognitive training did not have additive effects over physical training alone on physical activity, but multicomponent training and higher executive function at baseline may support adaptation to and maintenance of a physically active lifestyle among older adults.", "doi": "10.1371/journal.pone.0258559", "pmid": "34644357", "labels": {"Category: Proteins": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-19624"}, {"db": "pmc", "key": "PMC8513828"}], "notes": [], "created": "2021-10-21T05:07:40.043Z", "modified": "2021-10-21T05:07:40.098Z"}, {"entity": "publication", "iuid": "d70904b2b74441ef99cf0b79c91e8245", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d70904b2b74441ef99cf0b79c91e8245.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d70904b2b74441ef99cf0b79c91e8245"}}, "title": "SARS\u2013CoV\u20132 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro", "authors": [{"family": "Jiang", "given": "Hui", "initials": "H"}, {"family": "Mei", "given": "Ya Fang", "initials": "YF"}], "type": "journal-article", "published": "2021-10-13", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "10", "pages": "2056", "issn-l": "1999-4915"}, "abstract": null, "doi": "10.3390/v13102056", "pmid": null, "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:30:44.079Z", "modified": "2021-10-26T18:30:56.036Z"}, {"entity": "publication", "iuid": "1fd3d388b8404b7f82e9e5d7bffc160b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1fd3d388b8404b7f82e9e5d7bffc160b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1fd3d388b8404b7f82e9e5d7bffc160b"}}, "title": "Impact of obesity on intensive care outcomes in patients with COVID-19 in Sweden-A cohort study.", "authors": [{"family": "Sj\u00f6gren", "given": "Lovisa", "initials": "L", "orcid": "0000-0002-3425-0900", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e6cd7d544c04167bfb5cd8e7c7dc09f.json"}}, {"family": "Stenberg", "given": "Erik", "initials": "E", "orcid": "0000-0001-9189-0093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d991f094120449a7afaea3d92ade6db9.json"}}, {"family": "Thuccani", "given": "Meena", "initials": "M", "orcid": "0000-0003-2505-5596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/051393fe34b1472a83912bcf7b68713f.json"}}, {"family": "Martikainen", "given": "Jari", "initials": "J"}, {"family": "Rylander", "given": "Christian", "initials": "C", "orcid": "0000-0002-4534-7150", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/547f0c635e8144068a5dde0809547036.json"}}, {"family": "Wallenius", "given": "Ville", "initials": "V"}, {"family": "Olbers", "given": "Torsten", "initials": "T"}, {"family": "Kindblom", "given": "Jenny M", "initials": "JM", "orcid": "0000-0001-8437-0639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b24d2c900a84492a6e2974e5cf43751.json"}}], "type": "journal article", "published": "2021-10-13", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0257891", "issn-l": "1932-6203"}, "abstract": "Previous studies have shown that a high body mass index (BMI) is a risk factor for severe COVID-19. The aim of the present study was to assess whether a high BMI affects the risk of death or prolonged length of stay (LOS) in patients with COVID-19 during intensive care in Sweden.\n\nIn this observational, register-based study, we included patients with COVID-19 from the Swedish Intensive Care Registry admitted to intensive care units (ICUs) in Sweden. Outcomes assessed were death during intensive care and ICU LOS \u226514 days. We used logistic regression models to evaluate the association (odds ratio [OR] and 95% confidence interval [CI]) between BMI and the outcomes. Valid weight and height information could be retrieved in 1,649 patients (1,227 (74.4%) males) with COVID-19. We found a significant association between BMI and the risk of the composite outcome death or LOS \u226514 days in survivors (OR per standard deviation [SD] increase 1.30, 95%CI 1.16-1.44, adjusted for sex, age and comorbidities), and this association remained after further adjustment for severity of illness (simplified acute physiology score; SAPS3) at ICU admission (OR 1.30 per SD, 95%CI 1.17-1.45). Individuals with a BMI \u2265 35 kg/m2 had a doubled risk of the composite outcome. A high BMI was also associated with death during intensive care and a prolonged LOS in survivors assessed as separate outcomes. The main limitations were the restriction to the first wave of the pandemic, and the lack of information on socioeconomic status as well as smoking.\n\nIn this large cohort of Swedish ICU patients with COVID-19, a high BMI was associated with increasing risk of death and prolonged length of stay in the ICU. Based on our findings, we suggest that individuals with obesity should be more closely monitored when hospitalized for COVID-19.", "doi": "10.1371/journal.pone.0257891", "pmid": "34644316", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-22724"}, {"db": "pmc", "key": "PMC8513867"}], "notes": [], "created": "2021-10-21T05:08:00.061Z", "modified": "2021-10-21T05:08:00.267Z"}, {"entity": "publication", "iuid": "3a3e58bd90064b3889ef266c9471110b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a3e58bd90064b3889ef266c9471110b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a3e58bd90064b3889ef266c9471110b"}}, "title": "e-Learning and Web-Based Tools for Psychosocial Interventions Addressing Neuropsychiatric Symptoms of Dementia During the COVID-19 Pandemic in Tokyo, Japan: Quasi-Experimental Study.", "authors": [{"family": "Nakanishi", "given": "Miharu", "initials": "M", "orcid": "0000-0001-6200-9279", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/636f9920978f486c9148c073564a4b23.json"}}, {"family": "Yamasaki", "given": "Syudo", "initials": "S", "orcid": "0000-0002-9016-6404", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/703e839a200b4ef6b08be4c522562931.json"}}, {"family": "Endo", "given": "Kaori", "initials": "K", "orcid": "0000-0003-0854-5120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5173896a62eb481c8038090c4d1eb7a4.json"}}, {"family": "Niimura", "given": "Junko", "initials": "J", "orcid": "0000-0003-4404-055X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9765c54292f43ada4e4cb6448f9bed6.json"}}, {"family": "Ziylan", "given": "Canan", "initials": "C", "orcid": "0000-0002-7158-9508", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2af0a33c64c40a3ad69a89ac7c939fb.json"}}, {"family": "Bakker", "given": "Ton J E M", "initials": "TJEM", "orcid": "0000-0002-3773-5436", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6367f3e0f65340f5b699bcb1de688d1c.json"}}, {"family": "Granvik", "given": "Eva", "initials": "E", "orcid": "0000-0002-8862-8104", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b843c73baad49ac8c840c276621e567.json"}}, {"family": "N\u00e4gga", "given": "Katarina", "initials": "K", "orcid": "0000-0003-0194-8402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd0282d0489a4ee59dfe4f2fb4028093.json"}}, {"family": "Nishida", "given": "Atsushi", "initials": "A", "orcid": "0000-0001-6451-7699", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06cc5741754740a29041e4377f9207c3.json"}}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "JMIR Med Educ", "issn": "2369-3762", "volume": "7", "issue": "4", "pages": "e30652", "issn-l": null}, "abstract": "Concern has been raised that the COVID-19 pandemic and consequent social distancing measures may increase neuropsychiatric symptoms in people with dementia. Thus, we developed and delivered an e-learning training course to professional caregivers on using a web-based tool for psychosocial interventions for people with dementia.\n\nThe aim of our study was to evaluate the feasibility and efficacy of an e-learning course in combination with a web-based tool in addressing neuropsychiatric symptoms of dementia.\n\nA quasi-experimental design was used in Tokyo, Japan. The e-learning course was delivered three times to professional caregivers between July and December 2020. Caregivers who completed the course assessed the level of neuropsychiatric symptoms in people with dementia using the total score from the Neuropsychiatric Inventory (NPI) via a web-based tool. The primary outcome measures were the number of caregivers who implemented follow-up NPI evaluations by March 2021 and the change in NPI scores from baseline to their most recent follow-up evaluations. As a control group, information was also obtained from professional caregivers who completed a face-to-face training course using the same web-based tool between July 2019 and March 2020.\n\nA total of 268 caregivers completed the e-learning course in 2020. Of the 268 caregivers, 56 (20.9%) underwent follow-up evaluations with 63 persons with dementia. The average NPI score was significantly reduced from baseline (mean 20.4, SD 16.2) to the most recent follow-up evaluations (mean 14.3, SD 13.4). The effect size was assumed to be medium (Cohen drm [repeated measures]=0.40). The control group consisted of 252 caregivers who completed a face-to-face training course. Of the 252 caregivers, 114 (45.2%) underwent follow-up evaluations. Compared to the control group, caregivers who completed the e-learning course were significantly less likely to implement follow-up evaluations (\u03c721=52.0, P<.001). The change in NPI scores did not differ according to the type of training course (baseline-adjusted difference=-0.61, P=.69).\n\nThe replacement of face-to-face training with e-learning may have provided professionals with an opportunity to participate in the dementia behavior analysis and support enhancement (DEMBASE) program who may not have participated in the program otherwise. Although the program showed equal efficacy in terms of the two training courses, the feasibility was suboptimal with lower implementation levels for those receiving e-learning training. Thus, further strategies should be developed to improve feasibility by providing motivational triggers for implementation and technical support for care professionals. Using online communities in the program should also be investigated.", "doi": "10.2196/30652", "pmid": "34543224", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "v7i4e30652"}], "notes": [], "created": "2021-10-27T05:10:03.327Z", "modified": "2021-10-27T05:10:03.664Z"}, {"entity": "publication", "iuid": "80870541003147a987d11a033caf0d0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/80870541003147a987d11a033caf0d0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/80870541003147a987d11a033caf0d0e"}}, "title": "Susceptibility to COVID-19 after High Exposure to Perfluoroalkyl Substances from Contaminated Drinking Water: An Ecological Study from Ronneby, Sweden.", "authors": [{"family": "Nielsen", "given": "Christel", "initials": "C", "orcid": "0000-0003-3940-7847", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/383974c5a9e04eae926013a19be0fcdc.json"}}, {"family": "J\u00f6ud", "given": "Anna", "initials": "A", "orcid": "0000-0001-7192-4911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e038a5ce2f5a47bd89e7c221651a3d24.json"}}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "20", "pages": "10702", "issn-l": null}, "abstract": "There is concern that immunotoxic environmental contaminants, particularly perfluoroalkyl substances (PFAS), may play a role in the clinical course of COVID-19 and epidemiologic studies are needed to answer if high-exposed populations are especially vulnerable in light of the ongoing pandemic. The objective was, therefore, to determine if exposure to highly PFAS-contaminated drinking water was associated with an increased incidence of COVID-19 in Ronneby, Sweden, during the first year of the pandemic. We conducted an ecological study determining the sex- and age-standardized incidence ratio (SIR) in the adult population relative to a neighboring reference town with similar demographic characteristics but with only background levels of exposure. In Sweden, COVID-19 is subject to mandatory reporting, and we retrieved aggregated data on all verified cases until 3 March 2021 from the Public Health Agency of Sweden. The SIR in Ronneby was estimated at 1.19 (95% CI: 1.12; 1.27). The results suggest a potential link between high PFAS exposure and susceptibility to COVID-19 that warrants further research to clarify causality.", "doi": "10.3390/ijerph182010702", "pmid": "34682448", "labels": {"Category: Health": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8535293"}, {"db": "pii", "key": "ijerph182010702"}], "notes": [], "created": "2021-10-26T18:16:13.491Z", "modified": "2023-06-19T14:58:56.423Z"}, {"entity": "publication", "iuid": "67ed46cf180649afb240d1aa9ebef4e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/67ed46cf180649afb240d1aa9ebef4e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/67ed46cf180649afb240d1aa9ebef4e1"}}, "title": "Public justification and expert disagreement over non-pharmaceutical interventions for the COVID-19 pandemic.", "authors": [{"family": "Dahlquist", "given": "Marcus", "initials": "M"}, {"family": "Kugelberg", "given": "Henrik D", "initials": "HD", "orcid": "0000-0001-5119-646X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7330f66aa494bd1af8c79f6c9040620.json"}}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "J Med Ethics", "issn": "1473-4257", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "A wide range of non-pharmaceutical interventions (NPIs) have been introduced to stop or slow down the COVID-19 pandemic. Examples include school closures, environmental cleaning and disinfection, mask mandates, restrictions on freedom of assembly and lockdowns. These NPIs depend on coercion for their effectiveness, either directly or indirectly. A widely held view is that coercive policies need to be publicly justified-justified to each citizen-to be legitimate. Standardly, this is thought to entail that there is a scientific consensus on the factual propositions that are used to support the policies. In this paper, we argue that such a consensus has been lacking on the factual propositions justifying most NPIs. Consequently, they would on the standard view be illegitimate. This is regrettable since there are good reasons for granting the state the legitimate authority to enact NPIs under conditions of uncertainty. The upshot of our argument is that it is impossible to have both the standard interpretation of the permissibility of empirical claims in public justification and an effective pandemic response. We provide an alternative view that allows the state sufficient room for action while precluding the possibility of it acting without empirical support.", "doi": "10.1136/medethics-2021-107671", "pmid": "34642238", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "medethics-2021-107671"}], "notes": [], "created": "2021-10-21T05:08:50.893Z", "modified": "2022-02-17T11:29:15.608Z"}, {"entity": "publication", "iuid": "cbcfcaa21cfc4797bf135d15cff0e99a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cbcfcaa21cfc4797bf135d15cff0e99a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cbcfcaa21cfc4797bf135d15cff0e99a"}}, "title": "Prospective epidemiological, molecular, and genetic characterization of a novel coronavirus disease in the Val Venosta/Vinschgau: the CHRIS COVID-19 study protocol.", "authors": [{"family": "Pattaro", "given": "Cristian", "initials": "C", "orcid": "0000-0002-4119-0109", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf5065dd0f28451cbbe933b4a7de5985.json"}}, {"family": "Barbieri", "given": "Giulia", "initials": "G"}, {"family": "Foco", "given": "Luisa", "initials": "L", "orcid": "0000-0002-6694-3322", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/302e8d33f5154cfa9e61bae73c23eb36.json"}}, {"family": "Weichenberger", "given": "Christian X", "initials": "CX", "orcid": "0000-0002-2176-0274", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f73be54674f47cdb15cb55f83210783.json"}}, {"family": "Biasiotto", "given": "Roberta", "initials": "R"}, {"family": "De Grandi", "given": "Alessandro", "initials": "A"}, {"family": "Fuchsberger", "given": "Christian", "initials": "C"}, {"family": "Egger", "given": "Clemens", "initials": "C"}, {"family": "Amon", "given": "Vera S C", "initials": "VSC"}, {"family": "Hicks", "given": "Andrew A", "initials": "AA"}, {"family": "Mian", "given": "Michael", "initials": "M"}, {"family": "Mahlknecht", "given": "Angelika", "initials": "A"}, {"family": "Lombardo", "given": "Stefano", "initials": "S"}, {"family": "Meier", "given": "Horand", "initials": "H"}, {"family": "Weiss", "given": "Helmuth", "initials": "H"}, {"family": "Rainer", "given": "Robert", "initials": "R"}, {"family": "Dejaco", "given": "Christian", "initials": "C"}, {"family": "Weiss", "given": "G\u00fcnter", "initials": "G"}, {"family": "Lavezzo", "given": "Enrico", "initials": "E", "orcid": "0000-0002-3902-8356", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fdd6f6eb77a4a589afafc12955ca8d6.json"}}, {"family": "Crisanti", "given": "Andrea", "initials": "A"}, {"family": "Pizzato", "given": "Massimo", "initials": "M"}, {"family": "Domingues", "given": "Francisco S", "initials": "FS"}, {"family": "Mascalzoni", "given": "Deborah", "initials": "D"}, {"family": "G\u00f6gele", "given": "Martin", "initials": "M"}, {"family": "Melotti", "given": "Roberto", "initials": "R", "orcid": "0000-0003-4115-317X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9aadc5f020e74449a6ad0f6b87c55ec1.json"}}, {"family": "Pramstaller", "given": "Peter P", "initials": "PP"}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "Pathog Glob Health", "issn": "2047-7732", "pages": "1-9", "issn-l": null}, "abstract": "The COVID-19 pandemic has been threatening the healthcare and socioeconomic systems of entire nations. While population-based surveys to assess the distribution of SARS-CoV-2 infection have become a priority, pre-existing longitudinal studies are ideally suited to assess the determinants of COVID-19 onset and severity.The Cooperative Health Research In South Tyrol (CHRIS) study completed the baseline recruitment of 13,393 adults from the Venosta/Vinschgau rural district in 2018, collecting extensive phenotypic and biomarker data, metabolomic data, densely imputed genotype and whole-exome sequencing data.Based on CHRIS, we designed a prospective study, called CHRIS COVID-19, aimed at: 1) estimating the incidence of SARS-CoV-2 infections; 2) screening for and investigating the determinants of incident infection among CHRIS participants and their household members; 3) monitoring the immune response of infected participants prospectively.An online screening questionnaire was sent to all CHRIS participants and their household members. A random sample of 1450 participants representative of the district population was invited to assess active (nasopharyngeal swab) or past (serum antibody test) infections. We prospectively invited for complete SARS-CoV-2 testing all questionnaire completers gauged as possible cases of past infection and their household members. In positive tested individuals, antibody response is monitored quarterly for one year. Untested and negative participants receive the screening questionnaire every four weeks until gauged as possible incident cases or till the study end.Originated from a collaboration between researchers and community stakeholders, the CHRIS COVID-19 study aims at generating knowledge about the epidemiological, molecular, and genetic characterization of COVID-19 and its long-term sequelae.", "doi": "10.1080/20477724.2021.1978225", "pmid": "34637685", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8515786"}], "notes": [], "created": "2021-10-21T05:29:17.156Z", "modified": "2021-10-21T05:29:17.348Z"}, {"entity": "publication", "iuid": "ecfd334996f743f4b1001cd1f885ea98", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ecfd334996f743f4b1001cd1f885ea98.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ecfd334996f743f4b1001cd1f885ea98"}}, "title": "Organising labour market integration support for refugees in Austria and Sweden during the Covid-19 pandemic.", "authors": [{"family": "Be\u0161i\u0107", "given": "Almina", "initials": "A", "orcid": "0000-0003-4587-3609", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83a02c2a27944f7f8f3bf383b1dc1957.json"}}, {"family": "Diedrich", "given": "Andreas", "initials": "A"}, {"family": "Aigner", "given": "Petra", "initials": "P"}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "Comp Migr Stud", "issn": "2214-594X", "volume": "9", "issue": "1", "pages": "48", "issn-l": null}, "abstract": "This paper addresses the question of how the Covid-19 pandemic has affected the labour market integration support (LMIS) organised for refugees in Austria and Sweden, and the potential consequences of the changes unfolding. LMIS for refugees is a complex phenomenon involving actors at different interwoven levels-the macro-national level, the meso-organisational level and the micro-individual level. However, the complexities and consequences of such processes for the labour market integration of refugees have so far received limited attention. The current Covid-19 pandemic actualises the need to gain a better understanding of how integration support is organised across the different levels and how the pandemic itself impacts such support. Thus, the article seeks to understand how the pandemic affects the LMIS organised for refugees in Austria and Sweden, two countries with a large refugee population and diverging responses to the pandemic. Based on 29 semi-structured interviews and three focus group workshops, the results highlight in particular three developments: (a) a further entrenching of broader, macro-national level developments related to integration support already underway prior to the pandemic; (b) further mainstreaming of activities; and (c) increased volatility of work. Overall, the pandemic has brought to the fore the interrelation of different levels in the organising of LMIS for refugees and has contributed to a stabilisation of already ongoing activities.", "doi": "10.1186/s40878-021-00264-y", "pmid": "34660206", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "264"}, {"db": "pmc", "key": "PMC8507501"}], "notes": [], "created": "2021-10-21T05:01:14.127Z", "modified": "2021-10-21T05:01:14.195Z"}, {"entity": "publication", "iuid": "c54f0b8881fc4d8986c0453d0633d8d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c54f0b8881fc4d8986c0453d0633d8d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c54f0b8881fc4d8986c0453d0633d8d7"}}, "title": "High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells.", "authors": [{"family": "Sasamoto", "given": "Yuzuru", "initials": "Y"}, {"family": "Lee", "given": "Catherine A A", "initials": "CAA"}, {"family": "Yoshihara", "given": "Masahito", "initials": "M"}, {"family": "Martin", "given": "Gabrielle", "initials": "G"}, {"family": "Ksander", "given": "Bruce R", "initials": "BR"}, {"family": "Frank", "given": "Markus H", "initials": "MH"}, {"family": "Frank", "given": "Natasha Y", "initials": "NY"}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "Ocul Surf", "issn": "1937-5913", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jtos.2021.10.002", "pmid": "34653711", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1542-0124(21)00119-1"}], "notes": [], "created": "2021-10-21T05:04:34.147Z", "modified": "2021-10-21T05:04:34.184Z"}, {"entity": "publication", "iuid": "f78ed0896ec04ae2b27fe862816fab97", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f78ed0896ec04ae2b27fe862816fab97.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f78ed0896ec04ae2b27fe862816fab97"}}, "title": "Dynamic Interactions of Fully Glycosylated SARS-CoV-2 Spike Protein with Various Antibodies.", "authors": [{"family": "Cao", "given": "Yiwei", "initials": "Y", "orcid": "0000-0002-4516-8689", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15efd17a7c1342a3aa46bab1e2b9e241.json"}}, {"family": "Choi", "given": "Yeol Kyo", "initials": "YK", "orcid": "0000-0002-4218-7139", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2885ea927174b0aabe0ab76d5fba484.json"}}, {"family": "Frank", "given": "Martin", "initials": "M", "orcid": "0000-0002-1006-6746", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee6b5d165615455da3cf49fad65598e9.json"}}, {"family": "Woo", "given": "Hyeonuk", "initials": "H", "orcid": "0000-0002-6495-4087", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2dfd6c1c6f34de2b6b768ce70a67ebb.json"}}, {"family": "Park", "given": "Sang-Jun", "initials": "SJ", "orcid": "0000-0002-7307-3724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dede807702c34573bfe7de0b40c48de9.json"}}, {"family": "Yeom", "given": "Min Sun", "initials": "MS", "orcid": "0000-0001-9977-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7ae6fb73cfb47199fd5e4a468aa5554.json"}}, {"family": "Seok", "given": "Chaok", "initials": "C", "orcid": "0000-0002-1419-9888", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a93933221aa54cda9547eb7f063c154c.json"}}, {"family": "Im", "given": "Wonpil", "initials": "W", "orcid": "0000-0001-5642-6041", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c6b1fc87fa647459c5a112e9fa6b8ce.json"}}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "J Chem Theory Comput", "issn": "1549-9626", "issn-l": null, "volume": "17", "issue": "10", "pages": "6559-6569"}, "abstract": "The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents a public health crisis, and the vaccines that can induce highly potent neutralizing antibodies are essential for ending the pandemic. The spike (S) protein on the viral envelope mediates human angiotensin-converting enzyme 2 binding and thus is the target of a variety of neutralizing antibodies. In this work, we built various S trimer-antibody complex structures on the basis of the fully glycosylated S protein models described in our previous work and performed all-atom molecular dynamics simulations to gain insight into the structural dynamics and interactions between S protein and antibodies. Investigation of the residues critical for S-antibody binding allows us to predict the potential influence of mutations in SARS-CoV-2 variants. Comparison of the glycan conformations between S-only and S-antibody systems reveals the roles of glycans in S-antibody binding. In addition, we explored the antibody binding modes and the influences of antibody on the motion of S protein receptor binding domains. Overall, our analyses provide a better understanding of S-antibody interactions, and the simulation-based S-antibody interaction maps could be used to predict the influences of S mutation on S-antibody interactions, which will be useful for the development of vaccine and antibody-based therapy.", "doi": "10.1021/acs.jctc.1c00552", "pmid": "34529436", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null, "Category: Health": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC8457324"}], "notes": [], "created": "2021-09-20T16:50:33.864Z", "modified": "2023-06-19T14:35:10.854Z"}, {"entity": "publication", "iuid": "81d66a14c5ca493c826d3c9f0a089ec6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/81d66a14c5ca493c826d3c9f0a089ec6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/81d66a14c5ca493c826d3c9f0a089ec6"}}, "title": "Changes in Physical Activity Are Associated with Corresponding Changes in Psychological Well-Being: A Pandemic Case Study.", "authors": [{"family": "Dahlen", "given": "Micael", "initials": "M", "orcid": "0000-0001-6183-6520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5135c7c73d7f4eb89e26ec713dbfa2b8.json"}}, {"family": "Thorbj\u00f8rnsen", "given": "Helge", "initials": "H", "orcid": "0000-0002-2037-3336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46491c54156e4bdc85d376feda0fe55c.json"}}, {"family": "Sj\u00e5stad", "given": "Hallgeir", "initials": "H", "orcid": "0000-0002-8730-1038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9d4b3d4379f4e3bb43607c0ef08f159.json"}}, {"family": "von Heideken W\u00e5gert", "given": "Petra", "initials": "P", "orcid": "0000-0001-6292-7010", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4d6dfb26a37419385eb8e257f89d950.json"}}, {"family": "Hellstr\u00f6m", "given": "Charlotta", "initials": "C", "orcid": "0000-0003-1675-4408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a211ac4b50f24a3ca7be0deb42bc3362.json"}}, {"family": "Kerstis", "given": "Birgitta", "initials": "B", "orcid": "0000-0003-0242-0343", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b50ad01a7fdd43b589b7ec07cf98f220.json"}}, {"family": "Lindberg", "given": "Daniel", "initials": "D", "orcid": "0000-0002-8541-1727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f40c1556e4545a3a69893d276425af9.json"}}, {"family": "Stier", "given": "Jonas", "initials": "J", "orcid": "0000-0001-7832-2155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7bd46d9d05214eef8e677e69a8878291.json"}}, {"family": "Elv\u00e9n", "given": "Maria", "initials": "M", "orcid": "0000-0001-5356-916X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d90589956db4920b99e166ed4c6dfb2.json"}}], "type": "journal article", "published": "2021-10-12", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "20", "pages": null}, "abstract": "Societal crises and personal challenges are often followed by substantial changes in physical activity. Is there a link between such changes and psychological well-being? Seeking to answer this question, we conducted a correlational study on a representative sample in Sweden during the first year of the COVID-19 pandemic (N = 1035). About 49% of the sample had decreased their physical activity compared to their self-reported activity level prior to the pandemic, whereas 32% had increased it. The results showed a positive and robust association between changes in daily activity level and corresponding changes in psychological well-being. Specifically, individuals who had reduced their physical activity over the last year reported lower life satisfaction than before, and individuals who had increased their physical activity reported higher life satisfaction than before. The amount of complete physical inactivity (sitting) showed a similar pattern as the exercise data, meaning that individuals who reported increasing inactivity per day also reported a greater decline in life satisfaction. Additional analyses showed that the association between daily activity level and life satisfaction was somewhat stronger for men than for women, but there was no difference when comparing individual versus organized activities. The current study was based on a cross-sectional design, measuring self-reported change over time. Recent work from other research teams have used longitudinal data and experience-sampling in different settings, finding similar results. We conclude that there is good reason to recommend physical exercise as a coping strategy in difficult times.", "doi": "10.3390/ijerph182010680", "pmid": "34682427", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "ijerph182010680"}], "notes": [], "created": "2021-10-26T18:14:07.931Z", "modified": "2022-02-17T10:50:21.789Z"}, {"entity": "publication", "iuid": "fcbefce66e1c493f8ecbc002ec69bd19", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fcbefce66e1c493f8ecbc002ec69bd19.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fcbefce66e1c493f8ecbc002ec69bd19"}}, "title": "What has the COVID-19 pandemic taught us about conducting patient and public involvement remotely? Insights from a series of digital meeting observations.", "authors": [{"family": "Lampa", "given": "Elin", "initials": "E", "orcid": "0000-0002-5467-5850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ca616474534489e933171c9819c3869.json"}}, {"family": "Sonnentheil", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "T\u00f6k\u00e9s", "given": "Ant\u00f3nia", "initials": "A"}, {"family": "Warner", "given": "Georgina", "initials": "G"}], "type": "letter", "published": "2021-10-11", "journal": {"title": "Res Involv Engagem", "issn": "2056-7529", "issn-l": null, "volume": "7", "issue": "1", "pages": "73"}, "abstract": "During the COVID-19 pandemic many work tasks are being done remotely through digital meetings, including PPI in research. Yet, some PPI activities have been paused or cancelled altogether during the pandemic. In this commentary, we share our insights from observing digital meetings with researchers and public contributors, representing vulnerable groups. Additionally, we discuss how remote PPI activities can be understood and improved.\r\n\r\nAs part of a PPI evaluation project, live observations were conducted by two trained observers, using a semi-structured observation protocol developed to objectively assess aspects of group dynamics in PPI research meetings with public contributors with experience of seeking refuge and parents facing economic hardship. This project's data collection is ongoing and the insights in this commentary is based on the observers' discussion. We discuss these insights through the lens of the Media Richness Theory, stating that the choice of media we communicate through should be guided by what kind of information we want to communicate to each other. The more complex the information is, the richer the media tool needs to be. For example, information in a text message is more easily misinterpreted than information given in person. This is because meeting in person gives us more information, for example through body language and tone of voice. Based on our experiences from observing digital research meetings, we give suggestions on how to improve digital meetings with public contributors. A few key points are: actively choosing which media to use; being prepared to guide contributors to the chosen media in a way that is suitable for them; and the increased importance of the person chairing the meeting to actively include all participants.\r\n\r\nWe reach the conclusion that digital meetings with public contributors is possible, but that researchers need to make a commitment and actively work to solve practical issues. Finally, the format and structure of digital meetings should be co-created together with public contributors.", "doi": "10.1186/s40900-021-00315-9", "pmid": "34635179", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s40900-021-00315-9"}, {"db": "pmc", "key": "PMC8503706"}], "notes": [], "created": "2021-10-21T05:40:42.818Z", "modified": "2022-02-17T10:29:45.446Z"}, {"entity": "publication", "iuid": "f20b9edbcf6644cf8ffc8e845358ae08", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f20b9edbcf6644cf8ffc8e845358ae08.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f20b9edbcf6644cf8ffc8e845358ae08"}}, "title": "Time-dependent evolution of IgG antibody levels after first and second dose of mRNA-based SARS-CoV-2 vaccination in hemodialysis patients: a multicenter study.", "authors": [{"family": "Santos-Ara\u00fajo", "given": "Carla", "initials": "C"}, {"family": "Veiga", "given": "Pedro Mota", "initials": "PM"}, {"family": "Santos", "given": "M\u00e1rio Jo\u00e3o", "initials": "MJ"}, {"family": "Santos", "given": "Lidia", "initials": "L"}, {"family": "Rom\u00e3ozinho", "given": "Catarina", "initials": "C"}, {"family": "Silva", "given": "M\u00f3nica", "initials": "M"}, {"family": "Lucas", "given": "Carlos", "initials": "C"}, {"family": "Duarte", "given": "Mary Luz", "initials": "ML"}, {"family": "Haarhaus", "given": "Mathias", "initials": "M"}, {"family": "Haase", "given": "Michael", "initials": "M"}, {"family": "Mac\u00e1rio", "given": "Fernando", "initials": "F"}], "type": "journal article", "published": "2021-10-11", "journal": {"title": "Nephrol Dial Transplant", "issn": "1460-2385", "issn-l": "0931-0509"}, "abstract": "Vaccination programs are essential for the containment of the COVID-19 pandemic, which has affected hemodialysis populations especially hard. Early reports suggest a reduced immunologic response to SARS-Cov-2 vaccines in dialysis patients, in spite of a high degree of seroconversion. We aimed to identify risk factors for a reduced efficacy of an mRNA vaccine in a cohort of hemodialysis patients.\n\nIn a multicenter study, including 294 Portuguese hemodialysis patients who had received 2 doses of BNT162b2 with a three week interval, IgG-class antibodies against the SARS-CoV-2 spike protein were determined 3 weeks after the first dose (M1) and 6 weeks after the second dose (M2). The threshold for seroconversion was 10UR/mL. Demographic and clinical data was retrieved from a quality registry. Adverse events were registered using a questionnaire.\n\nAt M2, seroconversion was 93.1% with a median antibody level of 197.5U/mL (1.2-3237.0) and a median increase of 180.0U/mL (-82.9-2244.6) from M1. Age (beta -8.9; 95%CI: -12.88 to -4.91; P < 0.0001), ferritin > 600ng/mL (beta 183.93; 95%CI: 74.75 to 293.10; P = 0.001) and physical activity (beta 265.79; 95%CI: 30.7 to 500.88; P = 0.03) were independent predictors of SARS-Cov-2 antibody levels after two vaccine doses. Plasma albumin > 3.5g/dL independently predicted the increase of antibody levels between both doses (OR 14.72; 95%CI: 1.38 to 157.45; P = 0.03). Only mild adverse reactions were observed in 10.9% of patients.\n\nThe SARS-Cov-2 vaccine BNT162b2 is safe and effective in hemodialysis patients. Besides age, iron status and nutrition are possible modifiable modulators of the immunologic response to SARS-Cov-2 mRNA vaccines. This data suggests the need for an early identification of populations at higher risk for diminished antibody production and the potential advantage of the implementation of oriented strategies to maximize the immune response to vaccination in these patients.", "doi": "10.1093/ndt/gfab293", "pmid": "34634116", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "6388402"}], "notes": [], "created": "2021-10-21T05:41:56.358Z", "modified": "2021-10-21T05:42:07.316Z"}, {"entity": "publication", "iuid": "278a382c799044f9b790db547410274d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/278a382c799044f9b790db547410274d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/278a382c799044f9b790db547410274d"}}, "title": "Longitudinal experiences and impact of the COVID-19 pandemic among people with past or current eating disorders in Sweden.", "authors": [{"family": "Birgeg\u00e5rd", "given": "Andreas", "initials": "A", "orcid": "0000-0003-1220-9680", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ffef11fa1954f97b80d3d3a6817e71a.json"}}, {"family": "Abbaspour", "given": "Afrouz", "initials": "A"}, {"family": "Borg", "given": "Stina", "initials": "S"}, {"family": "Clinton", "given": "David", "initials": "D"}, {"family": "Mantilla", "given": "Emma Fors\u00e9n", "initials": "EF"}, {"family": "Savva", "given": "Androula", "initials": "A"}, {"family": "Termorshuizen", "given": "Jet D", "initials": "JD"}, {"family": "Bulik", "given": "Cynthia M", "initials": "CM"}], "type": "journal article", "published": "2021-10-11", "journal": {"title": "Eat Disord", "issn": "1532-530X", "pages": "1-16", "issn-l": null}, "abstract": "The study aimed to document the impact of the COVID-19 pandemic on the health and well-being of individuals with past and current eating disorders (ED) in Sweden. We re-contacted participants with a known lifetime history of ED from two previous Swedish studies. Participants completed an online survey about health and functioning at baseline early in the pandemic (Wave 1 ca May/June 2020; N= 982) and six months later (Wave 2 Dec/Jan 2020/21; N= 646). Three important patterns emerged: 1) higher current ED symptoms were associated with greater anxiety, worry, and pandemic-related ED symptom increase; 2) patterns were fairly stable across time, although a concerning percentage (23%) who were symptom-free at Wave 1 reported the re-emergence of symptoms at Wave 2; and 3) only a minority of participants (<50%) with a current ED were in treatment, and of those in treatment, many reported fewer treatment sessions and decreased quality of care. The COVID-19 pandemic appears to pose serious health challenges for individuals with an ED, whether currently symptomatic or in remission. We encourage health service providers and patient advocates to be alert to the needs of individuals with ED and to take active measures to ensure access to appropriate evidence-based care both during and following the pandemic.", "doi": "10.1080/10640266.2021.1985286", "pmid": "34634228", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-21T05:41:17.737Z", "modified": "2021-10-21T05:41:17.812Z"}, {"entity": "publication", "iuid": "0bfed88b3c994d329226611fc1d5840d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0bfed88b3c994d329226611fc1d5840d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0bfed88b3c994d329226611fc1d5840d"}}, "title": "Increased risk of hospitalisation and intensive care admission associated with reported cases of SARS-CoV-2 variants B.1.1.7 and B.1.351 in Norway, December 2020 -May 2021.", "authors": [{"family": "Veneti", "given": "Lamprini", "initials": "L", "orcid": "0000-0002-9117-5310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/692998f77204424dba01972130b83448.json"}}, {"family": "Sepp\u00e4l\u00e4", "given": "Elina", "initials": "E"}, {"family": "Larsdatter Storm", "given": "Margrethe", "initials": "M"}, {"family": "Valcarcel Salamanca", "given": "Beatriz", "initials": "B"}, {"family": "Alnes Buanes", "given": "Eirik", "initials": "E"}, {"family": "Aasand", "given": "Nina", "initials": "N"}, {"family": "Naseer", "given": "Umaer", "initials": "U"}, {"family": "Bragstad", "given": "Karoline", "initials": "K"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "B\u00f8\u00e5s", "given": "H\u00e5kon", "initials": "H"}, {"family": "Kv\u00e5le", "given": "Reidar", "initials": "R"}, {"family": "Golestani", "given": "Karan", "initials": "K"}, {"family": "Feruglio", "given": "Siri", "initials": "S"}, {"family": "Vold", "given": "Line", "initials": "L"}, {"family": "Nyg\u00e5rd", "given": "Karin", "initials": "K"}, {"family": "Whittaker", "given": "Robert", "initials": "R", "orcid": "0000-0003-2810-7734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be98797b0c2a4de68e6e9599e4d1fb0e.json"}}], "type": "journal article", "published": "2021-10-11", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0258513", "issn-l": "1932-6203"}, "abstract": "Since their emergence, SARS-CoV-2 variants of concern (VOC) B.1.1.7 and B.1.351 have spread worldwide. We estimated the risk of hospitalisation and admission to an intensive care unit (ICU) for infections with B.1.1.7 and B.1.351 in Norway, compared to infections with non-VOC.\n\nUsing linked individual-level data from national registries, we conducted a cohort study on laboratory-confirmed cases of SARS-CoV-2 in Norway diagnosed between 28 December 2020 and 2 May 2021. Variants were identified based on whole genome sequencing, partial sequencing by Sanger sequencing or PCR screening for selected targets. The outcome was hospitalisation or ICU admission. We calculated adjusted risk ratios (aRR) with 95% confidence intervals (CIs) using multivariable binomial regression to examine the association between SARS-CoV-2 variants B.1.1.7 and B.1.351 with i) hospital admission and ii) ICU admission compared to non-VOC.\n\nWe included 23,169 cases of B.1.1.7, 548 B.1.351 and 4,584 non-VOC. Overall, 1,017 cases were hospitalised (3.6%) and 206 admitted to ICU (0.7%). B.1.1.7 was associated with a 1.9-fold increased risk of hospitalisation (aRR 95%CI 1.6-2.3) and a 1.8-fold increased risk of ICU admission (aRR 95%CI 1.2-2.8) compared to non-VOC. Among hospitalised cases, no difference was found in the risk of ICU admission between B.1.1.7 and non-VOC. B.1.351 was associated with a 2.4-fold increased risk of hospitalisation (aRR 95%CI 1.7-3.3) and a 2.7-fold increased risk of ICU admission (aRR 95%CI 1.2-6.5) compared to non-VOC.\n\nOur findings add to the growing evidence of a higher risk of severe disease among persons infected with B.1.1.7 or B.1.351. This highlights the importance of prevention and control measures to reduce transmission of these VOC in society, particularly ongoing vaccination programmes, and preparedness plans for hospital surge capacity.", "doi": "10.1371/journal.pone.0258513", "pmid": "34634066", "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-21292"}, {"db": "pmc", "key": "PMC8504717"}], "notes": [], "created": "2021-10-21T05:42:38.657Z", "modified": "2021-10-21T05:42:38.755Z"}, {"entity": "publication", "iuid": "ad0ade1d4f684a8e8ba203c034450fec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ad0ade1d4f684a8e8ba203c034450fec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ad0ade1d4f684a8e8ba203c034450fec"}}, "title": "Covid-19: Sweden, Norway, and Finland suspend use of Moderna vaccine in young people \"as a precaution\".", "authors": [{"family": "Paterlini", "given": "Marta", "initials": "M"}], "type": "journal article", "published": "2021-10-11", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "375", "pages": "n2477", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.n2477", "pmid": "34635488", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-10-21T05:31:27.906Z", "modified": "2021-10-21T05:31:27.921Z"}, {"entity": "publication", "iuid": "7e5e4f36da9748f9a7017365af6f787b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e5e4f36da9748f9a7017365af6f787b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e5e4f36da9748f9a7017365af6f787b"}}, "title": "Association Between Risk of COVID-19 Infection in Nonimmune Individuals and COVID-19 Immunity in Their Family Members.", "authors": [{"family": "Nordstr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Ballin", "given": "Marcel", "initials": "M"}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-10-11", "journal": {"title": "JAMA Intern Med", "issn": "2168-6114", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The association between COVID-19 immunity within families and the risk of infection in nonimmune family members is unknown.\r\n\r\nTo investigate the association between risk of COVID-19 in nonimmune individuals and the number of their family members with known immunity acquired from a previous COVID-19 infection or full vaccination (2 vaccine doses).\r\n\r\nIn this cohort study of data from nationwide registries in Sweden, all individuals who acquired immunity from either previous COVID-19 infection or full vaccination until May 26, 2021, were considered for inclusion. Each person with immunity was matched 1:1 to an individual without immunity from an identified cohort of individuals with families comprising 2 to 5 members.\r\n\r\nNumber of immune family members in each family on April 14, 2021 (index date), who acquired immunity from a previous COVID-19 infection or full vaccination (2 doses of the mRNA-1273, BNT162b2 mRNA, or ChAdOx1 nCoV-19 vaccine).\r\n\r\nIncident COVID-19 infection in nonimmune family members from April 15 to May 26, 2021.\r\n\r\nA total of 1 789 728 individuals from 814 806 families were included in the analysis. Each family comprised 2 to 5 family members, with a mean (SD) age at baseline of 51.3 (19.5) years. During a mean (range) follow-up time of 26.3 (1-40) days, 88 797 of 1 549 989 (5.7%) nonimmune family members (mean [SD] age, 51.6 [17.7] years; 790 276 men [51.0%]) were diagnosed with COVID-19. There was an inverse dose-response association between the number of immune members in each family and the risk of incident COVID-19 infection in nonimmune family members. Nonimmune families with 1 immune family member had a 45% to 61% lower risk of contracting COVID-19 (hazard ratio [HR], 0.39-0.55; 95% CI, 0.37-0.61, P < .001). The risk reduction increased to 75% to 86% in families with 2 immune family members (HR, 0.14-0.25; 95% CI, 0.11-0.27; P < .001), 91% to 94% with 3 immune family members (HR, 0.06-0.09; 95% CI, 0.04-0.10; P < .001), and 97% with 4 immune family members (HR, 0.03; 95% CI, 0.02-0.05; P < .001). The results were similar for the outcome of COVID-19 infection that was severe enough to warrant a hospital stay.\r\n\r\nIn this cohort study, family members without immunity had a 45% to 97% lower risk of contracting COVID-19 as the number of immune family members increased. Vaccination is a key strategy for decreasing the transmission of the virus within families.", "doi": "10.1001/jamainternmed.2021.5814", "pmid": "34633407", "labels": {"Type: Journal article": null, "Category: Proteins": null}, "xrefs": [{"db": "pii", "key": "2785141"}], "notes": [], "created": "2021-10-21T05:44:00.849Z", "modified": "2021-10-21T05:45:09.824Z"}, {"entity": "publication", "iuid": "203b5fbee3e144d39ec6f59bfc384379", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/203b5fbee3e144d39ec6f59bfc384379.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/203b5fbee3e144d39ec6f59bfc384379"}}, "title": "Conquering the cytokine storm in COVID\u201019\u2010induced ARDS using placenta\u2010derived decidua stromal cells", "authors": [{"family": "Sadeghi", "given": "Behnam", "initials": "B", "orcid": "0000-0002-8721-0400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eadac43380f04ff58c964c3510e92151.json"}}, {"family": "Roshandel", "given": "Elham", "initials": "E"}, {"family": "Pirsalehi", "given": "Ali", "initials": "A"}, {"family": "Kazemi", "given": "Sepide", "initials": "S"}, {"family": "Sankanian", "given": "Ghazaleh", "initials": "G"}, {"family": "Majidi", "given": "Mohammad", "initials": "M"}, {"family": "Salimi", "given": "Maryam", "initials": "M"}, {"family": "Aghdami", "given": "Nasser", "initials": "N"}, {"family": "Sadrosadat", "given": "Hoda", "initials": "H"}, {"family": "Samadi Kochaksaraei", "given": "Sarvenaz", "initials": "S"}, {"family": "Alaeddini", "given": "Farshid", "initials": "F"}, {"family": "Ringden", "given": "Olle", "initials": "O"}, {"family": "Hajifathali", "given": "Abbas", "initials": "A"}], "type": "journal-article", "published": "2021-10-10", "journal": {"title": "J Cell Mol Med", "issn": "1582-1838", "issn-l": null}, "abstract": null, "doi": "10.1111/jcmm.16986", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:47:38.250Z", "modified": "2021-10-11T17:47:38.334Z"}, {"entity": "publication", "iuid": "64dc4d035e764b2593cd8aa0b4b542a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/64dc4d035e764b2593cd8aa0b4b542a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/64dc4d035e764b2593cd8aa0b4b542a4"}}, "title": "Transition to telehealth : Engaging medical students in telemedicine healthcare delivery.", "authors": [{"family": "Cheng", "given": "Chelsea", "initials": "C"}, {"family": "Humphreys", "given": "Hilary", "initials": "H", "orcid": "0000-0002-9646-2183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/743d1ac7fae6414881cdbbfd68ee700d.json"}}, {"family": "Kane", "given": "Bridget", "initials": "B", "orcid": "0000-0003-3211-6529", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4805745c1bc64db79cb7de66a19c24b9.json"}}], "type": "journal article", "published": "2021-10-09", "journal": {"title": "Ir J Med Sci", "issn": "1863-4362", "issn-l": null}, "abstract": "In recent years, telemedicine has been increasingly incorporated into medical practice, a process which has now been accelerated by the COVID-19 pandemic. As telemedicine continues to progress, it is necessary for medical institutions to incorporate telemedicine into their curricula, and to provide students with the necessary skills and experience to effectively carry out telemedicine consultations. The purposes of this study are to review the involvement of medical students with telemedicine and to determine both the benefits and the challenges experienced. A literature review on the MEDLINE; CINAHL Plus; APA PsychInfo; Library, Information Science and Technology Abstracts; and Health Business Elite databases was performed on September 7, 2020, yielding 561 results. 33 manuscripts were analysed, with the main benefits and challenges experienced by medical students summarized. In addition to increasing their understanding of the importance of telemedicine and the acquisition of telemedicine-specific skills, students may use telemedicine to act as a valuable workforce during the COVID-19 pandemic. Challenges that students face, such as discomfort with carrying out telemedicine consults and building rapport with patients, may be addressed through the incorporation of telemedicine teaching into the medical curricula through experiential learning. However, other more systemic challenges, such as technical difficulties and cost, need to be examined for the full benefits of telemedicine to be realized. Telemedicine is here to stay and has proven its worth during the COVID-19 pandemic, with medical students embracing its potential in assisting in medical clinics, simulation of clinical placements, and online classrooms.", "doi": "10.1007/s11845-021-02720-1", "pmid": "34626350", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11845-021-02720-1"}], "notes": [], "created": "2021-10-10T15:03:29.736Z", "modified": "2021-10-10T15:03:29.813Z"}, {"entity": "publication", "iuid": "9cf39ddf9f0c40979dc182c2bdcea414", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9cf39ddf9f0c40979dc182c2bdcea414.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9cf39ddf9f0c40979dc182c2bdcea414"}}, "title": "Severe COVID-19 among patients with asthma and COPD: a report from the Swedish National Airway Register.", "authors": [{"family": "Karlsson Sundbaum", "given": "Johanna", "initials": "J", "orcid": "0000-0001-5313-7981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8b5dfbfb761446aa474013fcccdd085.json"}}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW"}, {"family": "Konradsen", "given": "Jon R", "initials": "JR"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ekberg-Jansson", "given": "Ann", "initials": "A"}, {"family": "Stridsman", "given": "Caroline", "initials": "C", "orcid": "0000-0001-6622-3838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e2fc66fb68748eba5a7f8eb93c5ff3f.json"}}], "type": "journal article", "published": "2021-10-09", "journal": {"title": "Ther Adv Respir Dis", "issn": "1753-4666", "volume": "15", "pages": "17534666211049738", "issn-l": null}, "abstract": "Patients with obstructive lung diseases may be at risk of hospitalization and/or death due to COVID-19.\n\nTo estimate the frequency of severe COVID-19, and COVID-19-related mortality in a well-defined large population of patients with asthma and chronic inflammatory lung disease (COPD). Further to assess the frequency of asthma and COPD as registered comorbidities at discharge from hospital, and in death certificates.\n\nAt the start of the pandemic, the Swedish National Airway Register (SNAR) included 271,404 patients with a physician diagnosis of asthma and/or COPD. In September 2020, after the first COVID-19 wave in Sweden, the database was linked with the National Patient Register (NPR), the Swedish Intensive Care Register and the Swedish Cause of Death Register, which all provide data about COVID-19 based on International Classification of Diseases (ICD-10) codes. Severe COVID-19 was defined as hospitalization and/or intensive care or death due to COVID-19.\n\nAmong patients in SNAR, 0.5% with asthma, and 1.2% with COPD were identified with severe COVID-19. Among patients < 18 years with asthma, only 0.02% were severely infected. Of hospitalized adults, 14% with asthma and 29% with COPD died. Further, of patients in SNAR, 56% with asthma and 81% with COPD were also registered in the NPR, while on death certificates the agreement was lower (asthma 24% and COPD 71%).\n\nThe frequency of severe COVID-19 in asthma and COPD was relative low. Mortality for those hospitalized was double as high in COPD compared to asthma. Comorbid asthma and COPD were not always identified among patients with severe COVID-19.", "doi": "10.1177/17534666211049738", "pmid": "34623194", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:05:40.326Z", "modified": "2021-10-10T15:05:40.385Z"}, {"entity": "publication", "iuid": "79bc8a5e27924a4b85c44881e983c8fb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79bc8a5e27924a4b85c44881e983c8fb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79bc8a5e27924a4b85c44881e983c8fb"}}, "title": "Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: a systematic review and meta-analysis.", "authors": [{"family": "Vlieg-Boerstra", "given": "Berber", "initials": "B"}, {"family": "de Jong", "given": "Nicolette", "initials": "N"}, {"family": "Meyer", "given": "Rosan", "initials": "R"}, {"family": "Agostoni", "given": "Carlo", "initials": "C"}, {"family": "De Cosmi", "given": "Valentina", "initials": "V"}, {"family": "Grimshaw", "given": "Kate", "initials": "K"}, {"family": "Milani", "given": "Gregorio Paolo", "initials": "GP", "orcid": "0000-0003-3829-4254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ca1648b8a3104d04a1c1e76f1ab8515a.json"}}, {"family": "Muraro", "given": "Antonella", "initials": "A"}, {"family": "Oude Elberink", "given": "Hanneke", "initials": "H"}, {"family": "Pali-Sch\u00f6ll", "given": "Isabella", "initials": "I"}, {"family": "Roduit", "given": "Caroline", "initials": "C", "orcid": "0000-0002-5988-0570", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e16166b1fbb40b7889c82489fbdb715.json"}}, {"family": "Sasaki", "given": "Mari", "initials": "M"}, {"family": "Skypala", "given": "Isabel", "initials": "I", "orcid": "0000-0003-3629-4293", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4c207bd30ab42c1867b02a860c67f77.json"}}, {"family": "Solokowska", "given": "Milena", "initials": "M"}, {"family": "van Splunter", "given": "Marloes", "initials": "M"}, {"family": "Untersmayr", "given": "Eva", "initials": "E", "orcid": "0000-0002-1963-499X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8992d441a29644549f96af3a610c41ed.json"}}, {"family": "Venter", "given": "Carina", "initials": "C", "orcid": "0000-0002-7473-5355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ad020ad75c949809aea99fc0b4a3e9b.json"}}, {"family": "O'Mahony", "given": "Liam", "initials": "L"}, {"family": "Nwaru", "given": "Bright I", "initials": "BI", "orcid": "0000-0002-2876-6089", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2cf3592613946dda1712a7e78dd4c73.json"}}], "type": "journal article", "published": "2021-10-09", "journal": {"title": "Allergy", "issn": "1398-9995", "issn-l": "0105-4538"}, "abstract": "It remains uncertain as to whether nutrient supplementation for the general population considered healthy could be useful in the prevention of RTIs, such as COVID-19. In this systematic review and meta-analysis the evidence was evaluated for primary prevention of any viral respiratory tract infection (RTI) such as SARS-CoV-2, through supplementation of nutrients with a recognized role in immune function: multiple micronutrients, vitamin A, folic acid, vitamin B12, C, D, E, beta-carotene, zinc, iron and long chain polyunsaturated fatty acids. The search produced 15,163 records of which 93 papers (based on 115 studies) met the inclusion criteria, resulting in 199,055 subjects (191,636 children and 7,419 adults) from 37 countries. Sixty-three studies were included in the meta-analyses, which was performed for children and adults separately. By stratifying the meta-analysis by world regions, only studies performed in Asia showed a significant, but heterogeneous protective effect of zinc supplementation on RTIs (RR 0.86, 95%CI 0.7-0.96, I2=79.1%, p=0.000). Vitamin D supplementation in adults significantly decreased the incidence of RTI (RR 0.89, 95%CI 0.79-0.99, p=0.272), particularly in North America (RR 0.82 95%CI 0.68-0.97), but not in Europe or Oceania. Supplementation of nutrients in the general population has either no, or at most a very limited effect on prevention of RTIs. Zinc supplementation appears protective for children in Asia, while vitamin D may protect adults in the USA and Canada. In 10/115 (8.7%) studies post-hoc analyses based on stratification for nutritional status was performed. In only one study zinc supplementation was found to be more effective in children with low zinc serum as compared to children with normal zinc serum levels.", "doi": "10.1111/all.15136", "pmid": "34626488", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:03:11.116Z", "modified": "2021-10-10T15:03:11.258Z"}, {"entity": "publication", "iuid": "017cd45892f94e0fa1011237ba243d3c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/017cd45892f94e0fa1011237ba243d3c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/017cd45892f94e0fa1011237ba243d3c"}}, "title": "Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.", "authors": [{"family": "Pablos", "given": "Isabel", "initials": "I"}, {"family": "Machado", "given": "Yoan", "initials": "Y"}, {"family": "de Jesus", "given": "Hugo C Ramos", "initials": "HCR"}, {"family": "Mohamud", "given": "Yasir", "initials": "Y"}, {"family": "Kappelhoff", "given": "Reinhild", "initials": "R"}, {"family": "Lindskog", "given": "Cecilia", "initials": "C"}, {"family": "Vlok", "given": "Marli", "initials": "M"}, {"family": "Bell", "given": "Peter A", "initials": "PA"}, {"family": "Butler", "given": "Georgina S", "initials": "GS"}, {"family": "Grin", "given": "Peter M", "initials": "PM"}, {"family": "Cao", "given": "Quynh T", "initials": "QT"}, {"family": "Nguyen", "given": "Jenny P", "initials": "JP"}, {"family": "Solis", "given": "Nestor", "initials": "N"}, {"family": "Abbina", "given": "Srinivas", "initials": "S"}, {"family": "Rut", "given": "Wioletta", "initials": "W"}, {"family": "Vederas", "given": "John C", "initials": "JC"}, {"family": "Szekely", "given": "Laszlo", "initials": "L"}, {"family": "Szakos", "given": "Attila", "initials": "A"}, {"family": "Drag", "given": "Marcin", "initials": "M"}, {"family": "Kizhakkedathu", "given": "Jayachandran N", "initials": "JN"}, {"family": "Mossman", "given": "Karen", "initials": "K"}, {"family": "Hirota", "given": "Jeremy A", "initials": "JA"}, {"family": "Jan", "given": "Eric", "initials": "E"}, {"family": "Luo", "given": "Honglin", "initials": "H"}, {"family": "Banerjee", "given": "Arinjay", "initials": "A"}, {"family": "Overall", "given": "Christopher M", "initials": "CM"}], "type": "journal article", "published": "2021-10-09", "journal": {"title": "Cell Rep", "issn": "2211-1247", "pages": "109892", "issn-l": null}, "abstract": "The main viral protease (3CLpro) is indispensable for SARS-CoV-2 replication. We delineate the human protein substrate landscape of 3CLpro by TAILS substrate-targeted N-terminomics. We identify more than 100 substrates in human lung and kidney cells supported by analyses of SARS-CoV-2-infected cells. Enzyme kinetics and molecular docking simulations of 3CLpro engaging substrates reveal how noncanonical cleavage sites, which diverge from SARS-CoV, guide substrate specificity. Cleaving the interactors of essential effector proteins, effectively stranding them from their binding partners, amplifies the consequences of proteolysis. We show that 3CLpro targets the Hippo pathway, including inactivation of MAP4K5, and key effectors of transcription, mRNA processing, and translation. We demonstrate that Spike glycoprotein directly binds galectin-8, with galectin-8 cleavage disengaging CALCOCO2/NDP52 to decouple antiviral-autophagy. Indeed, in post-mortem COVID-19 lung samples, NDP52 rarely colocalizes with galectin-8, unlike in healthy lungs. The 3CLpro substrate degradome establishes a foundational substrate atlas to accelerate exploration of SARS-CoV-2 pathology and drug design.", "doi": "10.1016/j.celrep.2021.109892", "pmid": "34672947", "labels": {"Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2211-1247(21)01362-0"}], "notes": [], "created": "2021-10-26T18:09:25.642Z", "modified": "2021-10-26T18:09:25.660Z"}, {"entity": "publication", "iuid": "8d509d3e380942b3b6dbddd4253d9966", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d509d3e380942b3b6dbddd4253d9966.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d509d3e380942b3b6dbddd4253d9966"}}, "title": "COVID-19 in patients with autoimmune diseases: characteristics and outcomes in a multinational network of cohorts across three countries.", "authors": [{"family": "Tan", "given": "Eng Hooi", "initials": "EH"}, {"family": "Sena", "given": "Anthony G", "initials": "AG", "orcid": "0000-0001-8630-5347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9202e069d9c24646b006b6abb640b541.json"}}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A", "orcid": "0000-0003-1202-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47f086bb6ccd49a2a5f11a32c06277c8.json"}}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Ahmed", "given": "Waheed-Ul-Rahman", "initials": "WU"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Duvall", "given": "Scott L", "initials": "SL"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "Bertolin", "given": "Sergio Fernandez", "initials": "SF"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Natarajan", "given": "Karthik", "initials": "K"}, {"family": "Falconer", "given": "Thomas", "initials": "T"}, {"family": "Spotnitz", "given": "Matthew", "initials": "M"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Blacketer", "given": "Clair", "initials": "C"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Lane", "given": "Jennifer C E", "initials": "JCE"}, {"family": "Dawoud", "given": "Dalia M", "initials": "DM"}, {"family": "Shah", "given": "Karishma", "initials": "K"}, {"family": "Yang", "given": "Yue", "initials": "Y"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Recalde", "given": "Martina", "initials": "M"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "Jonnagaddala", "given": "Jitendra", "initials": "J", "orcid": "0000-0002-9912-2344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8403290b9ec43fe93b558de97d84559.json"}}, {"family": "Subbian", "given": "Vignesh", "initials": "V"}, {"family": "Vizcaya", "given": "David", "initials": "D"}, {"family": "Lai", "given": "Lana Y H", "initials": "LYH"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Shah", "given": "Nigam H", "initials": "NH"}, {"family": "Gong", "given": "Mengchun", "initials": "M"}, {"family": "Vivekanantham", "given": "Arani", "initials": "A"}, {"family": "Abend", "given": "Aaron", "initials": "A"}, {"family": "Minty", "given": "Evan P", "initials": "EP"}, {"family": "Suchard", "given": "Marc", "initials": "M"}, {"family": "Rijnbeek", "given": "Peter", "initials": "P"}, {"family": "Ryan", "given": "Patrick B", "initials": "PB"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}], "type": "journal article", "published": "2021-10-09", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "volume": "60", "issue": "SI", "pages": "SI37-SI50", "issn-l": null}, "abstract": "Patients with autoimmune diseases were advised to shield to avoid coronavirus disease 2019 (COVID-19), but information on their prognosis is lacking. We characterized 30-day outcomes and mortality after hospitalization with COVID-19 among patients with prevalent autoimmune diseases, and compared outcomes after hospital admissions among similar patients with seasonal influenza.\n\nA multinational network cohort study was conducted using electronic health records data from Columbia University Irving Medical Center [USA, Optum (USA), Department of Veterans Affairs (USA), Information System for Research in Primary Care-Hospitalization Linked Data (Spain) and claims data from IQVIA Open Claims (USA) and Health Insurance and Review Assessment (South Korea). All patients with prevalent autoimmune diseases, diagnosed and/or hospitalized between January and June 2020 with COVID-19, and similar patients hospitalized with influenza in 2017-18 were included. Outcomes were death and complications within 30 days of hospitalization.\n\nWe studied 133 589 patients diagnosed and 48 418 hospitalized with COVID-19 with prevalent autoimmune diseases. Most patients were female, aged \u226550 years with previous comorbidities. The prevalence of hypertension (45.5-93.2%), chronic kidney disease (14.0-52.7%) and heart disease (29.0-83.8%) was higher in hospitalized vs diagnosed patients with COVID-19. Compared with 70 660 hospitalized with influenza, those admitted with COVID-19 had more respiratory complications including pneumonia and acute respiratory distress syndrome, and higher 30-day mortality (2.2-4.3% vs 6.32-24.6%).\n\nCompared with influenza, COVID-19 is a more severe disease, leading to more complications and higher mortality.", "doi": "10.1093/rheumatology/keab250", "pmid": "33725121", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6174122"}, {"db": "pmc", "key": "PMC7989171"}], "notes": [], "created": "2021-03-17T07:42:16.376Z", "modified": "2021-11-18T13:19:42.279Z"}, {"entity": "publication", "iuid": "a45f65dfd0c5498abfbfcc9164c2cb6c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a45f65dfd0c5498abfbfcc9164c2cb6c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a45f65dfd0c5498abfbfcc9164c2cb6c"}}, "title": "Rapid evaluation of Coronavirus Illness Severity (RECOILS) in intensive care: Development and validation of a prognostic tool for in-hospital mortality.", "authors": [{"family": "Ple\u010dko", "given": "Drago", "initials": "D", "orcid": "0000-0002-5433-196X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9f5f12451ca40b0a93e4f2491dd3a92.json"}}, {"family": "Bennett", "given": "Nicolas", "initials": "N"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J", "orcid": "0000-0001-8739-7896", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04c2fb174ab842c8809900877de8c008.json"}}, {"family": "Dam", "given": "Tariq A", "initials": "TA"}, {"family": "Entjes", "given": "Robert", "initials": "R"}, {"family": "Rettig", "given": "Thijs C D", "initials": "TCD"}, {"family": "Dongelmans", "given": "Dave A", "initials": "DA"}, {"family": "Boelens", "given": "Age D", "initials": "AD"}, {"family": "Rigter", "given": "Sander", "initials": "S"}, {"family": "Hendriks", "given": "Stefaan H A", "initials": "SHA"}, {"family": "de Jong", "given": "Remko", "initials": "R"}, {"family": "Kamps", "given": "Marlijn J A", "initials": "MJA"}, {"family": "Peters", "given": "Marco", "initials": "M"}, {"family": "Karakus", "given": "Attila", "initials": "A"}, {"family": "Gommers", "given": "Diederik", "initials": "D"}, {"family": "Ramnarain", "given": "Dharmanand", "initials": "D"}, {"family": "Wils", "given": "Evert-Jan", "initials": "EJ"}, {"family": "Achterberg", "given": "Sefanja", "initials": "S"}, {"family": "Nowitzky", "given": "Ralph", "initials": "R"}, {"family": "van den Tempel", "given": "Walter", "initials": "W"}, {"family": "de Jager", "given": "Cornelis P C", "initials": "CPC"}, {"family": "Nooteboom", "given": "Fleur G C A", "initials": "FGCA"}, {"family": "Oostdijk", "given": "Evelien", "initials": "E"}, {"family": "Koetsier", "given": "Peter", "initials": "P"}, {"family": "Cornet", "given": "Alexander D", "initials": "AD"}, {"family": "Reidinga", "given": "Auke C", "initials": "AC"}, {"family": "de Ruijter", "given": "Wouter", "initials": "W"}, {"family": "Bosman", "given": "Rob J", "initials": "RJ"}, {"family": "Frenzel", "given": "Tim", "initials": "T"}, {"family": "Urlings-Strop", "given": "Louise C", "initials": "LC"}, {"family": "de Jong", "given": "Paul", "initials": "P"}, {"family": "Smit", "given": "Ellen G M", "initials": "EGM"}, {"family": "Cremer", "given": "Olaf L", "initials": "OL"}, {"family": "Mehagnoul-Schipper", "given": "D Jannet", "initials": "DJ"}, {"family": "Faber", "given": "Harald J", "initials": "HJ"}, {"family": "Lens", "given": "Judith", "initials": "J"}, {"family": "Brunnekreef", "given": "Gert B", "initials": "GB"}, {"family": "Festen-Spanjer", "given": "Barbara", "initials": "B"}, {"family": "Dormans", "given": "Tom", "initials": "T"}, {"family": "de Bruin", "given": "Daan P", "initials": "DP"}, {"family": "Lalisang", "given": "Robbert C A", "initials": "RCA"}, {"family": "Vonk", "given": "Sebastiaan J J", "initials": "SJJ"}, {"family": "Haan", "given": "Martin E", "initials": "ME"}, {"family": "Fleuren", "given": "Lucas M", "initials": "LM"}, {"family": "Thoral", "given": "Patrick J", "initials": "PJ"}, {"family": "Elbers", "given": "Paul W G", "initials": "PWG"}, {"family": "Bellomo", "given": "Rinaldo", "initials": "R"}], "type": "journal article", "published": "2021-10-08", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172"}, "abstract": "The prediction of in-hospital mortality for ICU patients with COVID-19 is fundamental to treatment and resource allocation. The main purpose was to develop an easily implemented score for such prediction.\n\nThis was an observational, multicenter, development and validation study on a national critical care dataset of COVID-19 patients. A systematic literature review was performed to determine variables possibly important for COVID-19 mortality prediction. Using a logistic multivariable model with a LASSO penalty, we developed the Rapid Evaluation of Coronavirus Illness Severity (RECOILS) score and compared its performance against published scores.\n\nOur development (validation) cohort consisted of 1480 (937) adult patients from 14 (11) Dutch ICUs admitted between March 2020 and April 2021. Median age was 65 (65) years, 31% (26%) died in hospital, 74% (72%) were males, average length of ICU stay was 7.83 (10.25) days and average length of hospital stay was 15.90 (19.92) days. Age, platelets, PaO2/FiO2 ratio, pH, blood urea nitrogen, temperature, PaCO2, Glasgow Coma Scale (GCS) score measured within +/- 24 hours of ICU admission were used to develop the score. The AUROC of RECOILS score was 0.75 (CI 0.71-0.78) which was higher than that of any previously reported predictive scores (0.68 (CI 0.64-0.71), 0.61 (CI 0.58-0.66), 0.67 (CI 0.63-0.70), 0.70 (CI 0.67-0.74) for ISARIC 4C Mortality Score, SOFA, SAPS-III, and age, respectively).\n\nUsing a large dataset from multiple Dutch ICUs, we developed a predictive score for mortality of COVID-19 patients admitted to ICU, which outperformed other predictive scores reported so far.", "doi": "10.1111/aas.13991", "pmid": "34622441", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:07:16.357Z", "modified": "2021-10-10T15:07:16.414Z"}, {"entity": "publication", "iuid": "77afdca8913f4abc8f52e71eb7efce65", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/77afdca8913f4abc8f52e71eb7efce65.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/77afdca8913f4abc8f52e71eb7efce65"}}, "title": "Impacts of mild COVID-19 on elevated use of primary and specialist health care services: A nationwide register study from Norway.", "authors": [{"family": "Skyrud", "given": "Katrine Damgaard", "initials": "KD", "orcid": "0000-0001-7504-9253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa7b45c41c544ba098093febd55117c8.json"}}, {"family": "Hern\u00e6s", "given": "Kjersti Helene", "initials": "KH"}, {"family": "Telle", "given": "Kjetil Elias", "initials": "KE"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2021-10-08", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0257926", "issn-l": "1932-6203"}, "abstract": "To explore the temporal impact of mild COVID-19 on need for primary and specialist health care services.\n\nIn all adults (\u226520 years) tested for SARS-CoV-2 in Norway March 1st 2020 to February 1st 2021 (N = 1 401 922), we contrasted the monthly all-cause health care use before and up to 6 months after the test (% relative difference), for patients with a positive test for SARS-CoV-2 (non-hospitalization, i.e. mild COVID-19) and patients with a negative test (no COVID-19).\n\nWe found a substantial short-term elevation in primary care use in all age groups, with men generally having a higher relative increase (men 20-44 years: 522%, 95%CI = 509-535, 45-69 years: 439%, 95%CI = 426-452, \u226570 years: 199%, 95%CI = 180-218) than women (20-44 years: 342, 95%CI = 334-350, 45-69 years = 375, 95%CI = 365-385, \u226570 years: 156%, 95%CI = 141-171) at 1 month following positive test. At 2 months, this sex difference was less pronounced, with a (20-44 years: 21%, 95%CI = 13-29, 45-69 years = 38%, 95%CI = 30-46, \u226570 years: 15%, 95%CI = 3-28) increase in primary care use for men, and a (20-44 years: 30%, 95%CI = 24-36, 45-69 years = 57%, 95%CI = 50-64, \u226570 years: 14%, 95%CI = 4-24) increase for women. At 3 months after test, only women aged 45-70 years still had an increased primary care use (14%, 95%CI = 7-20). The increase was due to respiratory- and general/unspecified conditions. We observed no long-term (4-6 months) elevation in primary care use, and no elevation in specialist care use.\n\nMild COVID-19 gives an elevated need for primary care that vanishes 2-3 months after positive test. Middle-aged women had the most prolonged increased primary care use.", "doi": "10.1371/journal.pone.0257926", "pmid": "34624023", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-20514"}], "notes": [], "created": "2021-10-10T15:04:07.839Z", "modified": "2021-10-10T15:04:07.870Z"}, {"entity": "publication", "iuid": "e63147ae2ad5461fab8c3c22dd457a15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e63147ae2ad5461fab8c3c22dd457a15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e63147ae2ad5461fab8c3c22dd457a15"}}, "title": "Depression and anxiety disorders during the COVID-19 pandemic: knowns and unknowns.", "authors": [{"family": "Taquet", "given": "Maxime", "initials": "M"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}, {"family": "Harrison", "given": "Paul J", "initials": "PJ"}], "type": "journal article", "published": "2021-10-08", "journal": {"title": "Lancet", "issn": "1474-547X", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(21)02221-2", "pmid": "34634251", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)02221-2"}], "notes": [], "created": "2021-10-21T05:40:59.740Z", "modified": "2021-10-21T05:40:59.753Z"}, {"entity": "publication", "iuid": "f1d72e38164244329f331bc86c438bb8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1d72e38164244329f331bc86c438bb8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1d72e38164244329f331bc86c438bb8"}}, "title": "Risk and protective factors, stressors, and symptoms of adjustment disorder during the COVID-19 pandemic - First results of the ESTSS COVID-19 pan-European ADJUST study.", "authors": [{"family": "Lotzin", "given": "Annett", "initials": "A", "orcid": "0000-0002-2834-8047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/414bdffc7c514b68ad7b342cd97121fa.json"}}, {"family": "Krause", "given": "Linda", "initials": "L"}, {"family": "Acquarini", "given": "Elena", "initials": "E"}, {"family": "Ajdukovic", "given": "Dean", "initials": "D"}, {"family": "Ardino", "given": "Vittoria", "initials": "V"}, {"family": "Arnberg", "given": "Filip", "initials": "F", "orcid": "0000-0002-1317-2093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b82329ec9cc545ee98bf639481323581.json"}}, {"family": "B\u00f6ttche", "given": "Maria", "initials": "M"}, {"family": "Bragesj\u00f6", "given": "Maria", "initials": "M", "orcid": "0000-0003-2246-3842", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/abec108719f641bf9fe4d0b13d62e327.json"}}, {"family": "Dragan", "given": "Ma\u0142gorzata", "initials": "M", "orcid": "0000-0001-8221-2012", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6abe40fed044419da5ab35e198fbacf8.json"}}, {"family": "Figueiredo-Braga", "given": "Margarida", "initials": "M"}, {"family": "Gelezelyte", "given": "Odeta", "initials": "O"}, {"family": "Grajewski", "given": "Piotr", "initials": "P"}, {"family": "Anastassiou-Hadjicharalambous", "given": "Xenia", "initials": "X"}, {"family": "Javakhishvili", "given": "Jana Darejan", "initials": "JD"}, {"family": "Kazlauskas", "given": "Evaldas", "initials": "E", "orcid": "0000-0002-6654-6220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/325ffed05ee04a7fb3aefc3dd9e168e1.json"}}, {"family": "Lenferink", "given": "Lonneke", "initials": "L", "orcid": "0000-0003-1329-6413", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d757067e8b284b5eac977e0dfd923967.json"}}, {"family": "Lioupi", "given": "Chrysanthi", "initials": "C"}, {"family": "Lueger-Schuster", "given": "Brigitte", "initials": "B", "orcid": "0000-0003-0784-8437", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e96be3831b3e43ed9980bdf9f8853899.json"}}, {"family": "Tsiskarishvili", "given": "Lela", "initials": "L"}, {"family": "Mooren", "given": "Trudy", "initials": "T"}, {"family": "Sales", "given": "Luisa", "initials": "L"}, {"family": "Stevanovic", "given": "Aleksandra", "initials": "A"}, {"family": "Zrnic", "given": "Irina", "initials": "I"}, {"family": "Sch\u00e4fer", "given": "Ingo", "initials": "I", "orcid": "0000-0002-9711-3559", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a082abe10d34bbbb8d3461dbf058cfd.json"}}], "type": "journal article", "published": "2021-10-07", "journal": {"title": "Eur J Psychotraumatol", "issn": "2000-8066", "volume": "12", "issue": "1", "pages": "1964197", "issn-l": null}, "abstract": "The COVID-19 pandemic exposes individuals to multiple stressors, such as quarantine, physical distancing, job loss, risk of infection, and loss of loved ones. Such a complex array of stressors potentially lead to symptoms of adjustment disorder.\n\nThis cross-sectional exploratory study examined relationships between risk and protective factors, stressors, and symptoms of adjustment disorder during the first year of the COVID-19 pandemic.\n\nData from the first wave of the European Society of Traumatic Stress Studies (ESTSS) longitudinal ADJUST Study were used. N = 15,563 participants aged 18 years and above were recruited in eleven countries (Austria, Croatia, Georgia, Germany, Greece, Italy, Lithuania, the Netherlands, Poland, Portugal, and Sweden) from June to November 2020. Associations between risk and protective factors (e.g. gender, diagnosis of a mental health disorder), stressors (e.g. fear of infection, restricted face-to-face contact), and symptoms of adjustment disorder (ADNM-8) were examined using multivariate linear regression.\n\nThe prevalence of self-reported probable adjustment disorder was 18.2%. Risk factors associated with higher levels of symptoms of adjustment disorder were female gender, older age, being at risk for severe COVID-19 illness, poorer general health status, current or previous trauma exposure, a current or previous mental health disorder, and longer exposure to COVID-19 news. Protective factors related to lower levels of symptoms of adjustment disorder were higher income, being retired, and having more face-to-face contact with loved ones or friends. Pandemic-related stressors associated with higher levels of symptoms of adjustment disorder included fear of infection, governmental crisis management, restricted social contact, work-related problems, restricted activity, and difficult housing conditions.\n\nWe identified stressors, risk, and protective factors that may help identify individuals at higher risk for adjustment disorder.", "doi": "10.1080/20008198.2021.1964197", "pmid": "34992755", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "1964197"}, {"db": "pmc", "key": "PMC8725769"}], "notes": [], "created": "2022-01-10T15:31:26.902Z", "modified": "2022-01-10T15:31:28.538Z"}, {"entity": "publication", "iuid": "5327d5834c684edc9a2a761b3d58d128", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5327d5834c684edc9a2a761b3d58d128.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5327d5834c684edc9a2a761b3d58d128"}}, "title": "Reduced ability to produce reflex-evoked neurogenic inflammation, a sign of decreased defense against COVID-19 infection?", "authors": [{"family": "Malm", "given": "Lars", "initials": "L", "orcid": "0000-0002-3408-4455", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee058659e4c64f6db787c4b9f19eec6c.json"}}], "type": "journal article", "published": "2021-10-07", "journal": {"title": "Skin Res Technol", "issn": "1600-0846", "issn-l": null}, "abstract": "A histamine skin prick test (SPT) generally evokes a wheal and a flare. The present study was initiated by an observation that histamine did not evoke a flare around a wheal in the skin of an 86-year-old man. Could that be of relevance to the findings that old men are prone to a more severe COVD-19 infection with a higher mortality than young ones?\n\nHistamine SPT was performed on the forearm of six old men, all above the age of 80. The skin reactions were photographed from above and from the side. The photographs taken from above were treated in a computer with LYYN, a program that increases color differences. With the help of ImageJ (NIH), the size relation between flare and wheal was calculated. On the photographs, taken as side views, areas, heights, and diameters of wheals were measured. Controls consisted of three groups of younger people.\n\nAmong the old men, no or only a small flare was seen. All the controls had prominent flares. Histamine SPT evoked small wheals in the group of old men as compared to young men.\n\nReduced neurogenic inflammation evoked by histamine from mast cells in blood and tissue may reduce the defense against COVID-19 infection.", "doi": "10.1111/srt.13089", "pmid": "34618975", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:24:02.582Z", "modified": "2021-10-10T15:24:12.373Z"}, {"entity": "publication", "iuid": "f6c40f5a5c124c73adee6ac3acba4ad1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6c40f5a5c124c73adee6ac3acba4ad1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6c40f5a5c124c73adee6ac3acba4ad1"}}, "title": "Quantifying the impacts of human mobility restriction on the spread of coronavirus disease 2019: an empirical analysis from 344 cities of China.", "authors": [{"family": "Tan", "given": "Jing", "initials": "J"}, {"family": "Zhao", "given": "Shao-Yang", "initials": "SY"}, {"family": "Xiong", "given": "Yi-Quan", "initials": "YQ"}, {"family": "Liu", "given": "Chun-Rong", "initials": "CR"}, {"family": "Huang", "given": "Shi-Yao", "initials": "SY"}, {"family": "Lu", "given": "Xin", "initials": "X"}, {"family": "Thabane", "given": "Lehana", "initials": "L"}, {"family": "Xie", "given": "Feng", "initials": "F"}, {"family": "Sun", "given": "Xin", "initials": "X"}, {"family": "Li", "given": "Wei-Min", "initials": "WM"}], "type": "journal article", "published": "2021-10-07", "journal": {"title": "Chin Med J (Engl)", "issn": "2542-5641", "volume": "134", "issue": "20", "pages": "2438-2446", "issn-l": null}, "abstract": "Since the outbreak of coronavirus disease 2019 (COVID-19), human mobility restriction measures have raised controversies, partly because of the inconsistent findings. An empirical study is promptly needed to reliably assess the causal effects of the mobility restriction. The purpose of this study was to quantify the causal effects of human mobility restriction on the spread of COVID-19.\n\nOur study applied the difference-in-difference (DID) model to assess the declines of population mobility at the city level, and used the log-log regression model to examine the effects of population mobility declines on the disease spread measured by cumulative or new cases of COVID-19 over time after adjusting for confounders.\n\nThe DID model showed that a continual expansion of the relative declines over time in 2020. After 4 weeks, population mobility declined by -54.81% (interquartile range, -65.50% to -43.56%). The accrued population mobility declines were associated with the significant reduction of cumulative COVID-19 cases throughout 6 weeks (ie, 1% decline of population mobility was associated with 0.72% [95% CI: 0.50%-0.93%] reduction of cumulative cases for 1 week, 1.42% 2 weeks, 1.69% 3 weeks, 1.72% 4 weeks, 1.64% 5 weeks, and 1.52% 6 weeks). The impact on the weekly new cases seemed greater in the first 4 weeks but faded thereafter. The effects on cumulative cases differed by cities of different population sizes, with greater effects seen in larger cities.\n\nPersistent population mobility restrictions are well deserved. Implementation of mobility restrictions in major cities with large population sizes may be even more important.", "doi": "10.1097/CM9.0000000000001763", "pmid": "34620748", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8654447"}, {"db": "pii", "key": "00029330-202110200-00009"}], "notes": [], "created": "2021-10-10T15:09:25.592Z", "modified": "2023-06-19T15:32:35.419Z"}, {"entity": "publication", "iuid": "588404bd37a041b58b8b940a9211a7a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/588404bd37a041b58b8b940a9211a7a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/588404bd37a041b58b8b940a9211a7a2"}}, "title": "Monetary incentives increase COVID-19 vaccinations.", "authors": [{"family": "Campos-Mercade", "given": "Pol", "initials": "P", "orcid": "0000-0002-7396-6514", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f4066be7689442009ba93911c0ec8771.json"}}, {"family": "Meier", "given": "Armando N", "initials": "AN", "orcid": "0000-0001-7977-8875", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3742dc32640c487eaee5493c1ae3432c.json"}}, {"family": "Schneider", "given": "Florian H", "initials": "FH", "orcid": "0000-0002-8406-2756", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76b238f01e6749bab5aefb7308ba056d.json"}}, {"family": "Meier", "given": "Stephan", "initials": "S", "orcid": "0000-0001-6726-9731", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d19cff065b54dea9974baeff383b788.json"}}, {"family": "Pope", "given": "Devin", "initials": "D", "orcid": "0000-0002-6567-9654", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2c1fb2cb5704cd08f6a919b071e4c4e.json"}}, {"family": "Wengstr\u00f6m", "given": "Erik", "initials": "E", "orcid": "0000-0002-1414-9055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e53ebfb55494b95911dcac8ad5e2a8b.json"}}], "type": "journal article", "published": "2021-10-07", "journal": {"title": "Science", "issn": "1095-9203", "pages": "eabm0475", "issn-l": "0036-8075"}, "abstract": "[Figure: see text].", "doi": "10.1126/science.abm0475", "pmid": "34618594", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:24:52.231Z", "modified": "2021-10-10T15:24:52.385Z"}, {"entity": "publication", "iuid": "38c7f28743fe4af18264ee231be1f617", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38c7f28743fe4af18264ee231be1f617.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38c7f28743fe4af18264ee231be1f617"}}, "title": "Cardiovascular Magnetic Resonance for Patients With COVID-19.", "authors": [{"family": "Petersen", "given": "Steffen E", "initials": "SE"}, {"family": "Friedrich", "given": "Matthias G", "initials": "MG"}, {"family": "Leiner", "given": "Tim", "initials": "T"}, {"family": "Elias", "given": "Matthew D", "initials": "MD"}, {"family": "Ferreira", "given": "Vanessa M", "initials": "VM"}, {"family": "Fenski", "given": "Maximilian", "initials": "M"}, {"family": "Flamm", "given": "Scott D", "initials": "SD"}, {"family": "Fogel", "given": "Mark", "initials": "M"}, {"family": "Garg", "given": "Ria", "initials": "R"}, {"family": "Halushka", "given": "Marc K", "initials": "MK"}, {"family": "Hays", "given": "Allison G", "initials": "AG"}, {"family": "Kawel-Boehm", "given": "Nadine", "initials": "N"}, {"family": "Kramer", "given": "Christopher M", "initials": "CM"}, {"family": "Nagel", "given": "Eike", "initials": "E"}, {"family": "Ntusi", "given": "Ntobeko A B", "initials": "NAB"}, {"family": "Ostenfeld", "given": "Ellen", "initials": "E"}, {"family": "Pennell", "given": "Dudley J", "initials": "DJ"}, {"family": "Raisi-Estabragh", "given": "Zahra", "initials": "Z"}, {"family": "Reeder", "given": "Scott B", "initials": "SB"}, {"family": "Rochitte", "given": "Carlos E", "initials": "CE"}, {"family": "Starekova", "given": "Jitka", "initials": "J"}, {"family": "Such\u00e1", "given": "Dominika", "initials": "D"}, {"family": "Tao", "given": "Qian", "initials": "Q"}, {"family": "Schulz-Menger", "given": "Jeanette", "initials": "J"}, {"family": "Bluemke", "given": "David A", "initials": "DA"}], "type": "journal article", "published": "2021-10-07", "journal": {"title": "JACC Cardiovasc Imaging", "issn": "1876-7591", "issn-l": null}, "abstract": "COVID-19 is associated with myocardial injury caused by ischemia, inflammation, or myocarditis. Cardiovascular magnetic resonance (CMR) is the noninvasive reference standard for cardiac function, structure, and tissue composition. CMR is a potentially valuable diagnostic tool in patients with COVID-19 presenting with myocardial injury and evidence of cardiac dysfunction. Although COVID-19-related myocarditis is likely infrequent, COVID-19-related cardiovascular histopathology findings have been reported in up to 48% of patients, raising the concern for long-term myocardial injury. Studies to date report CMR abnormalities in 26% to 60% of hospitalized patients who have recovered from COVID-19, including functional impairment, myocardial tissue abnormalities, late gadolinium enhancement, or pericardial abnormalities. In athletes post-COVID-19, CMR has detected myocarditis-like abnormalities. In children, multisystem inflammatory syndrome may occur 2 to 6 weeks after infection; associated myocarditis and coronary artery aneurysms are evaluable by CMR. At this time, our understanding of COVID-19-related cardiovascular involvement is incomplete, and multiple studies are planned to evaluate patients with COVID-19 using CMR. In this review, we summarize existing studies of CMR for patients with COVID-19 and present ongoing research. We also provide recommendations for clinical use of CMR for patients with acute symptoms or who are recovering from COVID-19.", "doi": "10.1016/j.jcmg.2021.08.021", "pmid": "34656482", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1936-878X(21)00688-4"}], "notes": [], "created": "2021-10-21T05:03:00.026Z", "modified": "2021-10-21T05:03:00.039Z"}, {"entity": "publication", "iuid": "41da54b6251142b5a37a2d2c195e3744", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41da54b6251142b5a37a2d2c195e3744.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41da54b6251142b5a37a2d2c195e3744"}}, "title": "COVID-19 and the ageing workforce: global perspectives on needs and solutions across 15 countries.", "authors": [{"family": "Pit", "given": "Sabrina", "initials": "S", "orcid": "0000-0003-2410-0703", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10d28d10de7246d892a63c541aeb4be0.json"}}, {"family": "Fisk", "given": "Malcolm", "initials": "M"}, {"family": "Freihaut", "given": "Winona", "initials": "W"}, {"family": "Akintunde", "given": "Fashola", "initials": "F"}, {"family": "Aloko", "given": "Bamidele", "initials": "B"}, {"family": "Berge", "given": "Britta", "initials": "B"}, {"family": "Burmeister", "given": "Anne", "initials": "A"}, {"family": "Ciac\u00e2ru", "given": "Adriana", "initials": "A"}, {"family": "Deller", "given": "J\u00fcrgen", "initials": "J"}, {"family": "Dulmage", "given": "Rae", "initials": "R"}, {"family": "Han", "given": "Tae Hwa", "initials": "TH"}, {"family": "Hao", "given": "Qiang", "initials": "Q"}, {"family": "Honeyman", "given": "Peter", "initials": "P"}, {"family": "Huber", "given": "Peter C", "initials": "PC"}, {"family": "Linner", "given": "Thomas", "initials": "T"}, {"family": "Lundberg", "given": "Stefan", "initials": "S"}, {"family": "Nwamara", "given": "Mofoluwaso", "initials": "M"}, {"family": "Punpuing", "given": "Kamolpun", "initials": "K"}, {"family": "Schramm", "given": "Jennifer", "initials": "J"}, {"family": "Yamada", "given": "Hajime", "initials": "H"}, {"family": "Yap", "given": "Jason C H", "initials": "JCH"}], "type": "letter", "published": "2021-10-07", "journal": {"title": "Int J Equity Health", "issn": "1475-9276", "volume": "20", "issue": "1", "pages": "221", "issn-l": null}, "abstract": "COVID-19 has a direct impact on the employment of older people. This adds to the challenge of ageism. The World Health Organization has started a worldwide campaign to combat ageism and has called for more research and evidence-based strategies that have the potential to be scaled up. This study specifically aims to identify solutions to combat the adverse effects of COVID-19 on the global ageing workforce.\n\nWe present 15 case studies from different countries and report on what those countries are doing or not doing to address the impact of COVID-19 on ageing workers.\n\nWe provide examples of how COVID-19 influences older people's ability to work and stay healthy, and offer case studies of what governments, organizations or individuals can do to help ensure older people can obtain, maintain and, potentially, expand their current work. Case studies come from Australia, Austria, Canada, China, Germany, Israel, Japan, Nigeria, Romania, Singapore, Sweden, South Korea, Thailand, United Kingdom (UK), and the United States (US). Across the countries, the impact of COVID-19 on older workers is shown as widening inequalities. A particular challenge has arisen because of a large proportion of older people, often with limited education and working in the informal sector within rural areas, e.g. in Nigeria, Thailand and China. Remedies to the particular disadvantage experienced by older workers in the context of COVID are presented. These range from funding support to encouraging business continuity, innovative product and service developments, community action, new business models and localized, national and international actions. The case studies can be seen as frequently fitting within strategies that have been proven to work in reducing ageism within the workplace. They include policy and laws that have increased benefits to workers during lockdowns (most countries); educational activities such as coaching seniorpreneurship (e,g, Australia); intergenerational contact interventions such as younger Thai people who moved back to rural areas and sharing their digital knowledge with older people and where older people reciprocate by teaching the younger people farming knowledge.\n\nGlobal sharing of this knowledge among international, national and local governments and organizations, businesses, policy makers and health and human resources experts will further understanding of the issues that are faced by older workers. This will facilitate the replication or scalability of solutions as called for in the WHO call to combat ageism in 2021. We suggest that policy makers, business owners, researchers and international organisations build on the case studies by investing in evidence-based strategies to create inclusive workplaces. Such action will thus help to challenge ageism, reduce inequity, improve business continuity and add to the quality of life of older workers.", "doi": "10.1186/s12939-021-01552-w", "pmid": "34620164", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12939-021-01552-w"}], "notes": [], "created": "2021-10-10T15:11:05.307Z", "modified": "2021-10-10T15:11:19.877Z"}, {"entity": "publication", "iuid": "d6b5dfe0a80a42fda6b2fec7020b8aa9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d6b5dfe0a80a42fda6b2fec7020b8aa9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d6b5dfe0a80a42fda6b2fec7020b8aa9"}}, "title": "Antigen receptor stimulation drives selection against pathogenic mtDNA variants that dysregulate lymphocyte responses", "authors": [{"family": "Zhang", "given": "Jingdian", "initials": "J", "orcid": "0000-0002-5685-8386", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/139b5809061346d39e002c77816fde6a.json"}}, {"family": "Koolmeister", "given": "Camilla", "initials": "C", "orcid": "0000-0002-4052-3442", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4297e6da55f4b3c8fd076fa713feb10.json"}}, {"family": "Han", "given": "Jinming", "initials": "J", "orcid": "0000-0002-6084-3275", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb80d9babf4c44ba9a253e9d4fdd0ce2.json"}}, {"family": "Filograna", "given": "Roberta", "initials": "R", "orcid": "0000-0002-6581-9426", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7a885a6fd994c0fb9be5380566db317.json"}}, {"family": "Hanke", "given": "Leo", "initials": "L", "orcid": "0000-0001-5514-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a35f10de4f2e4aee98278f6ab845613d.json"}}, {"family": "\u00c0dori", "given": "Monika", "initials": "M"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ", "orcid": "0000-0002-0227-5636", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a612a313d5874131ba64d9811a5d4a08.json"}}, {"family": "Teifel", "given": "Sina", "initials": "S"}, {"family": "Liu", "given": "Yong", "initials": "Y"}, {"family": "Harris", "given": "Robert A", "initials": "RA", "orcid": "0000-0003-4990-509X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/281bc302a3134c2288944689057586b0.json"}}, {"family": "Murrell", "given": "Ben", "initials": "B", "orcid": "0000-0002-0393-4445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60dac9ecf84d4eb3b90fb4ee1298bc52.json"}}, {"family": "Mcinerney", "given": "Gerald", "initials": "G", "orcid": "0000-0003-2257-7241", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7770437d845444a8a07865bf5b62fab0.json"}}, {"family": "Aoun", "given": "Mike", "initials": "M", "orcid": "0000-0002-7814-3787", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11060fd375054a4fa3038f0a46ad5c94.json"}}, {"family": "B\u00e4ckdahl", "given": "Liselotte", "initials": "L"}, {"family": "Holmdahl", "given": "Rikard", "initials": "R", "orcid": "0000-0002-4969-2576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/583b21b385a747a5a75695c08847b61b.json"}}, {"family": "Pekalski", "given": "Marcin", "initials": "M", "orcid": "0000-0001-7623-4370", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d12f48c2a2d4c6ea50af0f51e90c83b.json"}}, {"family": "Wedell", "given": "Anna", "initials": "A", "orcid": "0000-0002-2612-6301", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a2177a737cb4fd8b49af5af451a7a3f.json"}}, {"family": "Engvall", "given": "Martin", "initials": "M", "orcid": "0000-0002-8339-3545", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4eb7b09c59d48579d33248024846c16.json"}}, {"family": "Wredenberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-2500-6121", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58d21281196345539d7c55bc4e778c24.json"}}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB", "orcid": "0000-0001-7255-9047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/891aa9ca3f604b7396a14d65a33c2187.json"}}, {"family": "Dopico", "given": "Xaquin Castro", "initials": "XC", "orcid": "0000-0002-9005-6774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/354c91b234fd4a039f85c13e7e4209c1.json"}}, {"family": "Rorbach", "given": "Joanna", "initials": "J", "orcid": "0000-0002-2891-2840", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ddfd02a56dc4c43ac6e01c113c19874.json"}}], "type": "posted-content", "published": "2021-10-07", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.10.05.21264464", "pmid": null, "labels": {"Category: Biochemistry": null, "Funder: VR": null, "Category: Health": null, "Funder: H2020": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:42:30.709Z", "modified": "2021-10-26T18:42:31.160Z"}, {"entity": "publication", "iuid": "e441333fa3164d2f8f0112b4397e2684", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e441333fa3164d2f8f0112b4397e2684.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e441333fa3164d2f8f0112b4397e2684"}}, "title": "Androgen deprivation therapy and excess mortality in men with prostate cancer during the initial phase of the COVID-19 pandemic.", "authors": [{"family": "Gedeborg", "given": "Rolf", "initials": "R", "orcid": "0000-0002-8850-7863", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/234ef51ed7854efb8bbadc3ce35bf7d9.json"}}, {"family": "Styrke", "given": "Johan", "initials": "J"}, {"family": "Loeb", "given": "Stacy", "initials": "S"}, {"family": "Garmo", "given": "Hans", "initials": "H"}, {"family": "Stattin", "given": "P\u00e4r", "initials": "P", "orcid": "0000-0002-8306-0687", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/504d868e215c41ab8a75cb2e6cd289b8.json"}}], "type": "journal article", "published": "2021-10-07", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0255966", "issn-l": "1932-6203"}, "abstract": "Men have a higher risk of death from COVID-19 than women and androgens facilitate entrance of the SARS-CoV-2 virus into respiratory epithelial cells. Thus, androgen deprivation therapy may reduce infection rates and improve outcomes for COVID-19. In the spring of 2020, Sweden was highly affected by COVID-19. The aim was to estimate the impact of androgen deprivation therapy on mortality from COVID-19 in men with prevalent prostate cancer by comparing all-cause mortality in the spring of 2020 to that in previous years.\n\nUsing the Prostate Cancer data Base Sweden all men with prostate cancer on March 1 each year in 2015-2020 were followed until June 30 the same year. Exposure to androgen deprivation therapy was ascertained from filled prescriptions for bicalutamide monotherapy, gonadotropin-releasing hormone agonists (GnRH), or bilateral orchidectomy.\n\nA total of 9,822 men died in March-June in the years 2015-2020, of whom 5,034 men were on androgen deprivation therapy. There was an excess mortality in 2020 vs previous years in all men. The crude relative mortality rate ratio for 2020 vs 2015-2019 was 0.93 (95% confidence interval (CI) 0.83 to 1.04) in men on GnRH, and 0.90 (95% CI 0.78 to 1.05) in men on bicalutamide monotherapy. After multivariable adjustment these ratios were attenuated to 1.00 (95% CI 0.89 to 1.12) and 0.97 (95% CI 0.84 to 1.12), respectively. When restricting the analysis to the regions with the highest incidence of COVID-19 or to the time period between 2 April to 10 June when mortality in 2020 was increased >30% compared to previous years, the results were similar to the main analysis.\n\nIn this large national population-based cohort of men with prevalent prostate cancer, there was no clear evidence in support for an effect of androgen deprivation therapy on COVID-19 mortality.", "doi": "10.1371/journal.pone.0255966", "pmid": "34618806", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-04843"}], "notes": [], "created": "2021-10-10T15:24:32.122Z", "modified": "2021-10-10T15:24:32.184Z"}, {"entity": "publication", "iuid": "6366e1e82162434eb530528760477605", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6366e1e82162434eb530528760477605.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6366e1e82162434eb530528760477605"}}, "title": "A cell-free high throughput assay for assessment of SARS-CoV-2 neutralizing antibodies.", "authors": [{"family": "Mravinacova", "given": "Sara", "initials": "S"}, {"family": "J\u00f6nsson", "given": "Malin", "initials": "M"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Yousef", "given": "Jamil", "initials": "J"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Tegel", "given": "Hanna", "initials": "H"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Hober", "given": "Sophia", "initials": "S"}], "type": "journal article", "published": "2021-10-07", "journal": {"title": "N Biotechnol", "issn": "1876-4347", "issn-l": null, "volume": "66", "issue": null, "pages": "46-52"}, "abstract": "Highly accurate serological tests are key to assessing the prevalence of SARS-CoV-2 antibodies and the level of immunity in the population. This is important to predict the current and future status of the pandemic. With the recent emergence of new and more infectious SARS-CoV-2 variants, assays allowing for high throughput analysis of antibodies able to neutralize SARS-CoV-2 become even more important. Here, we report the development and validation of a robust, high throughput method, which enables the assessment of antibodies inhibiting the binding between the SARS-CoV-2 spike protein and angiotensin converting enzyme 2 (ACE2). The assay uses recombinantly produced spike-f and ACE2 and is performed in a bead array format, which allows analysis of up to 384 samples in parallel per instrument over seven hours, demanding only one hour of manual handling. The method is compared to a microneutralization assay utilising live SARS-CoV-2 and is shown to deliver highly correlating data. Further, a comparison with a serological method that measures all antibodies recognizing the spike protein shows that this type of assessment provides important insights into the neutralizing efficiency of the antibodies, especially for individuals with low antibody levels. This method can be an important and valuable tool for large-scale assessment of antibody-based neutralization, including neutralization of new spike variants that might emerge.", "doi": "10.1016/j.nbt.2021.10.002", "pmid": "34628049", "labels": {"Research Area: High-throughput and high-content serology": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Research Area: Host cell systems biology and targets": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: H2020": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1871-6784(21)00091-1"}, {"db": "pmc", "key": "PMC8495044"}], "notes": [], "created": "2021-10-11T17:45:54.123Z", "modified": "2021-11-18T16:29:35.546Z"}, {"entity": "publication", "iuid": "4a866576db52433b8a76b49766800900", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4a866576db52433b8a76b49766800900.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4a866576db52433b8a76b49766800900"}}, "title": "Social Jetlag Changes During the COVID-19 Pandemic as a Predictor of Insomnia - A Multi-National Survey Study.", "authors": [{"family": "Brand\u00e3o", "given": "Luiz Eduardo Mateus", "initials": "LEM", "orcid": "0000-0002-8672-7870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5d4c5e8bc704f2cb500e28e657ea315.json"}}, {"family": "Martikainen", "given": "Teemu", "initials": "T", "orcid": "0000-0003-2399-5138", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f163f4fee7514093a8fa354b45a137c8.json"}}, {"family": "Merikanto", "given": "Ilona", "initials": "I", "orcid": "0000-0002-1222-6678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50ed32f3146e4c0aa13e934d46eeb4af.json"}}, {"family": "Holzinger", "given": "Brigitte", "initials": "B", "orcid": "0000-0001-5385-4091", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/179fc564b66746d2a981082e5411d762.json"}}, {"family": "Morin", "given": "Charles M", "initials": "CM", "orcid": "0000-0002-8649-8895", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd42cb2cf7194992b7c06fac723e6ceb.json"}}, {"family": "Espie", "given": "Colin A", "initials": "CA", "orcid": "0000-0002-1294-8734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60482d2788b1405fb87b71442f703529.json"}}, {"family": "Bolstad", "given": "Courtney J", "initials": "CJ", "orcid": "0000-0003-2297-2778", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f47da3539dc4c0c95abe747ddd2fb55.json"}}, {"family": "Leger", "given": "Damien", "initials": "D", "orcid": "0000-0003-1168-480X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2cf778dd1ed9418bb0c182347f1a0355.json"}}, {"family": "Chung", "given": "Frances", "initials": "F", "orcid": "0000-0001-9576-3606", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed55f48b6d8e400b8fd2c591a738260a.json"}}, {"family": "Plazzi", "given": "Giuseppe", "initials": "G", "orcid": "0000-0002-1051-0472", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1a913222e004ad088535b1a251c8b7a.json"}}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y", "orcid": "0000-0003-0683-6506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/630f66dea3ce4ff2afe3c46f7827355b.json"}}, {"family": "Matsui", "given": "Kentaro", "initials": "K", "orcid": "0000-0003-4538-5381", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9e5535bdd6f48d79c36d3170c28f67c.json"}}, {"family": "De Gennaro", "given": "Luigi", "initials": "L", "orcid": "0000-0003-3613-6631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e700e607f114414dba66aa366e3158b6.json"}}, {"family": "Sieminski", "given": "Mariusz", "initials": "M", "orcid": "0000-0001-8219-2912", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7f92e908212f4d859cb42261a43c47c2.json"}}, {"family": "Nadorff", "given": "Michael R", "initials": "MR"}, {"family": "Chan", "given": "Ngan Yin", "initials": "NY", "orcid": "0000-0002-3009-3565", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e0c796d43e5947b6890322603ad7a318.json"}}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK", "orcid": "0000-0002-5745-5474", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bbe4815f36d48959f5e81a5cf650088.json"}}, {"family": "Mota-Rolim", "given": "S\u00e9rgio Arthuro", "initials": "SA", "orcid": "0000-0003-0196-5421", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/345ba991c90a4c8689f51366dfbeba54.json"}}, {"family": "Inoue", "given": "Yuichi", "initials": "Y", "orcid": "0000-0001-7414-9017", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cd6cb8358f04e8c9c11e1ecd0f03a58.json"}}, {"family": "Partinen", "given": "Markku", "initials": "M", "orcid": "0000-0002-8182-9368", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7920bcc4716848f7bd1cb89c8bdd0d5a.json"}}, {"family": "Benedict", "given": "Christian", "initials": "C", "orcid": "0000-0002-8911-4068", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a61aee14ada46ce968c40c652ac72df.json"}}, {"family": "Bjorvatn", "given": "Bjorn", "initials": "B", "orcid": "0000-0001-7051-745X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b72d97a35fa4590b5d05f0fd3524f2e.json"}}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-9052-8372", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36e153ded210463a84153370c34fa843.json"}}], "type": "journal article", "published": "2021-10-06", "journal": {"title": "Nat Sci Sleep", "issn": "1179-1608", "volume": "13", "pages": "1711-1722", "issn-l": null}, "abstract": "Lifestyle and work habits have been drastically altered by restrictions due to the COVID-19 pandemic. Whether the associated changes in sleep timing modulate the risk of suffering from symptoms of insomnia, the most prevalent sleep disorder, is however incompletely understood. Here, we evaluate the association between the early pandemic-associated change in 1) the magnitude of social jetlag (SJL) - ie, the difference between sleep timing on working vs free days - and 2) symptoms of insomnia.\n\nA total of 14,968 anonymous participants (mean age: 40 years; 64% females) responded to a standardized internet-based survey distributed across 14 countries. Using logistic multivariate regression, we examined the association between the degree of social jetlag and symptoms of insomnia, controlling for important confounders like social restriction extension, country specific COVID-19 severity and psychological distress, for example.\n\nIn response to the pandemic, participants reported later sleep timing, especially during workdays. Most participants (46%) exhibited a reduction in their SJL, whereas 20% increased it; and 34% reported no change in SJL. Notably, we found that both increased and decreased SJL, as a result of the COVID-19 pandemic, were associated with later sleep midpoint (indicating a later chronotype) as well as more recurrent and moderate-to-severe symptoms of insomnia (about 23-54% higher odds ratio than subjects with unchanged SJL). Primarily those with reduced SJL shifted their bedtimes to a later timepoint, compared with those without changes in SJL.\n\nOur findings offer important insights into how self-reported changes to the stability of sleep/wake timing, as reflected by changes in SJL, can be a critical marker of the risk of experiencing insomnia-related symptoms - even when individuals manage to reduce their social jetlag. These findings emphasize the clinical importance of analyzing sleep-wake regularity.", "doi": "10.2147/NSS.S327365", "pmid": "34675720", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "327365"}, {"db": "pmc", "key": "PMC8502537"}], "notes": [], "created": "2021-10-26T18:11:31.595Z", "modified": "2021-10-26T18:11:32.221Z"}, {"entity": "publication", "iuid": "a124c47fcd2d40ed9743d00c5abf6747", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a124c47fcd2d40ed9743d00c5abf6747.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a124c47fcd2d40ed9743d00c5abf6747"}}, "title": "Self-Transcendence as a Buffer Against COVID-19 Suffering: The Development and Validation of the Self-Transcendence Measure-B.", "authors": [{"family": "Wong", "given": "Paul T P", "initials": "PTP"}, {"family": "Arslan", "given": "G\u00f6kmen", "initials": "G"}, {"family": "Bowers", "given": "Victoria L", "initials": "VL"}, {"family": "Peacock", "given": "Edward J", "initials": "EJ"}, {"family": "Kjell", "given": "Oscar Nils Erik", "initials": "ONE"}, {"family": "Ivtzan", "given": "Itai", "initials": "I"}, {"family": "Lomas", "given": "Tim", "initials": "T"}], "type": "journal article", "published": "2021-10-06", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "12", "issue": null, "pages": "648549"}, "abstract": "The age of COVID-19 calls for a different approach toward global well-being and flourishing through the transcendence suffering as advocated by existential positive psychology. In the present study, we primarily explained what self-transcendence is and why it represents the most promising path for human beings to flourish through the transformation of suffering in a difficult and uncertain world. After reviewing the literature on self-transcendence experiences, we concluded that the model of self-transcendence presented by Frankl is able to integrate both of the characteristics associated with self-transcendence. Afterward, we discussed how the self-transcendence paradigm proposed by Wong, an extension of the model by Frankl, may help awaken our innate capacity for connections with the true self, with others, and with God or something larger than oneself. We presented self-transcendence as a less-traveled but more promising route to achieve personal growth and mental health in troubled times. Finally, we presented the history of the development and psychometrics of the Self-Transcendence Measure-Brief (STM-B) and reported the empirical evidence that self-transcendence served as a buffer against COVID-19 suffering. The presented data in the current study suggested that the best way to overcome pandemic suffering and mental health crises is to cultivate self-transcendence.", "doi": "10.3389/fpsyg.2021.648549", "pmid": "34690853", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8527188"}], "notes": [], "created": "2021-10-26T18:20:37.527Z", "modified": "2022-02-17T10:26:17.592Z"}, {"entity": "publication", "iuid": "320201f5551b4ad4b0fe9d47ac3d3376", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/320201f5551b4ad4b0fe9d47ac3d3376.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/320201f5551b4ad4b0fe9d47ac3d3376"}}, "title": "Experiences of Renal Replacement Therapy Delivery in Swedish Intensive Care Units during the COVID-19 Pandemic.", "authors": [{"family": "Hertzberg", "given": "Daniel", "initials": "D"}, {"family": "Renberg", "given": "M\u00e5rten", "initials": "M"}, {"family": "Nyman", "given": "Jesper", "initials": "J"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "Rimes Stigare", "given": "Claire", "initials": "C"}], "type": "journal article", "published": "2021-10-06", "journal": {"title": "Blood Purif", "issn": "1421-9735", "pages": "1-6", "issn-l": null}, "abstract": "The COVID-19 pandemic led to a rapidly increased demand for intensive care unit (ICU) and renal replacement therapy (RRT) worldwide. RRT delivery was threatened by a lack of specially trained staff and equipment. We investigated how the first wave of COVID-19 affected RRT delivery in Swedish ICUs.\n\nAn Internet-based questionnaire was sent to ICU lead physicians which included quantitative and qualitative questions regarding RRT demand, equipment availability, and use of continuous renal replacement therapy (CRRT), intermittent haemodialysis (IHD), and peritoneal dialysis (PD) during spring 2020.\n\nTwenty-five ICUs responded and these treated 64% of COVID-19 ICU patients in Sweden. ICU capacity increased by 292% (IQR 171-347%). Median peak capacity was reached during the 18th week of the year. RRT use increased overall by 133% and in Stockholm by 188%. 36% of units sequestered CRRT machines. IHD was used in 68% and PD in 12% of ICUs. RRT fluid and filter shortages were experienced by 45% and 33% of wards, respectively; consequently, prescription alterations were made by 24% of ICUs. Calcium solution shortages were reported in 12% of units that led to citrate protocol changes. Staffing shortages resulted in RRT sometimes being delivered by non-RRT-trained staff, safety incidents relating to this occurred, although no patient harm was reported.\n\nDuring the first wave of the COVID-19 pandemic, RRT demand increased extensively causing staff and equipment shortages, altered CRRT protocols, and increased use of IHD and PD. The impact on patient outcomes should be assessed to effectively plan for further surge capacity RRT demand.", "doi": "10.1159/000519261", "pmid": "34614497", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "000519261"}], "notes": [], "created": "2021-10-10T15:25:47.568Z", "modified": "2021-10-10T15:25:47.591Z"}, {"entity": "publication", "iuid": "2325938297904701a52685931800a279", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2325938297904701a52685931800a279.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2325938297904701a52685931800a279"}}, "title": "Distance learning in higher education during COVID-19: The role of basic psychological needs and intrinsic motivation for persistence and procrastination-a multi-country study.", "authors": [{"family": "Pelikan", "given": "Elisabeth R", "initials": "ER", "orcid": "0000-0003-2317-9237", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7015e04c057e420ab0b089a179feaed0.json"}}, {"family": "Korlat", "given": "Selma", "initials": "S", "orcid": "0000-0001-5719-5222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb333a31bbcf430c8bc4e88aad915429.json"}}, {"family": "Reiter", "given": "Julia", "initials": "J", "orcid": "0000-0002-7451-9441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d718a2b09a844ecac9d63f048732d91.json"}}, {"family": "Holzer", "given": "Julia", "initials": "J", "orcid": "0000-0002-0029-3291", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb443253e26f454589e051a5ab7cc115.json"}}, {"family": "Mayerhofer", "given": "Martin", "initials": "M", "orcid": "0000-0002-2978-4385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0477f9f8f9904dc6b257c5f6d31386fb.json"}}, {"family": "Schober", "given": "Barbara", "initials": "B"}, {"family": "Spiel", "given": "Christiane", "initials": "C"}, {"family": "Hamzallari", "given": "Oriola", "initials": "O", "orcid": "0000-0002-1154-7779", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7cfac7d82c94ba8833a7aa3fea2c1f0.json"}}, {"family": "Uka", "given": "Ana", "initials": "A", "orcid": "0000-0002-9039-8504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/813556c4adc8489cab0cfd710d42b0b3.json"}}, {"family": "Chen", "given": "Jiarui", "initials": "J"}, {"family": "V\u00e4lim\u00e4ki", "given": "Maritta", "initials": "M"}, {"family": "Puhari\u0107", "given": "Zrinka", "initials": "Z"}, {"family": "Anusionwu", "given": "Kelechi Evans", "initials": "KE", "orcid": "0000-0002-2946-076X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c0f0fc7278c448fb35962ececa3a0ed.json"}}, {"family": "Okocha", "given": "Angela Nkem", "initials": "AN", "orcid": "0000-0002-8668-6183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4fc8fcd5e4754cfeb7f671155089bc97.json"}}, {"family": "Zabrodskaja", "given": "Anastassia", "initials": "A"}, {"family": "Salmela-Aro", "given": "Katariina", "initials": "K"}, {"family": "K\u00e4ser", "given": "Udo", "initials": "U"}, {"family": "Schultze-Krumbholz", "given": "Anja", "initials": "A"}, {"family": "Wachs", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-2787-6646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b86f9438ea894681afe3ed3b75b93c91.json"}}, {"family": "Fri\u00f0riksson", "given": "Finnur", "initials": "F"}, {"family": "Gunn\u00fe\u00f3rsd\u00f3ttir", "given": "Herm\u00edna", "initials": "H"}, {"family": "H\u00f6ller", "given": "Yvonne", "initials": "Y"}, {"family": "Aoyama", "given": "Ikuko", "initials": "I"}, {"family": "Ieshima", "given": "Akihiko", "initials": "A", "orcid": "0000-0001-6423-375X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5df4f3f0e605406fbe93edba3abfaa49.json"}}, {"family": "Toda", "given": "Yuichi", "initials": "Y"}, {"family": "Konjufca", "given": "Jon", "initials": "J"}, {"family": "Llullaku", "given": "Njomza", "initials": "N"}, {"family": "Gedutien\u0117", "given": "Reda", "initials": "R"}, {"family": "Borg Axisa", "given": "Glorianne", "initials": "G"}, {"family": "Avirovic Bundalevska", "given": "Irena", "initials": "I", "orcid": "0000-0002-1609-000X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7b03d30dc8a437789778827cbdc9bc2.json"}}, {"family": "Keskinova", "given": "Angelka", "initials": "A", "orcid": "0000-0002-3698-0501", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a67f06d40fd042bd8d7ecbfdff33933f.json"}}, {"family": "Radulovic", "given": "Makedonka", "initials": "M", "orcid": "0000-0002-3753-1521", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9da2b609843042ada1ed1f22296e1d08.json"}}, {"family": "Lewandowska-Walter", "given": "Aleksandra", "initials": "A"}, {"family": "Micha\u0142ek-Kwiecie\u0144", "given": "Justyna", "initials": "J"}, {"family": "Plichta", "given": "Piotr", "initials": "P"}, {"family": "Py\u017calski", "given": "Jacek", "initials": "J", "orcid": "0000-0001-5817-276X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8072f973e24740f88e300907e166d361.json"}}, {"family": "Walter", "given": "Natalia", "initials": "N", "orcid": "0000-0002-2347-9312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a00af7a0664848bbbf2d9356924d8aca.json"}}, {"family": "Cautisanu", "given": "Cristina", "initials": "C", "orcid": "0000-0002-4457-1185", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/308dce29591748d087647da56445b1ca.json"}}, {"family": "Voda", "given": "Ana Iolanda", "initials": "AI"}, {"family": "Gao", "given": "Shang", "initials": "S", "orcid": "0000-0002-3722-6797", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/045bf868b2e14614985d01eab4a1a021.json"}}, {"family": "Islam", "given": "Sirajul", "initials": "S", "orcid": "0000-0002-7907-6037", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e05dfe6ec254efe8e7f98a35ab5728d.json"}}, {"family": "Wistrand", "given": "Kai", "initials": "K", "orcid": "0000-0002-1394-3783", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e776d6c1c4b4cdaa5452120b388678c.json"}}, {"family": "Wright", "given": "Michelle F", "initials": "MF"}, {"family": "L\u00fcftenegger", "given": "Marko", "initials": "M", "orcid": "0000-0001-8112-976X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f123b600b20342719f0c25cce9974e60.json"}}], "type": "journal article", "published": "2021-10-06", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "10", "pages": "e0257346", "issn-l": "1932-6203"}, "abstract": "Due to the COVID-19 pandemic, higher educational institutions worldwide switched to emergency distance learning in early 2020. The less structured environment of distance learning forced students to regulate their learning and motivation more independently. According to self-determination theory (SDT), satisfaction of the three basic psychological needs for autonomy, competence and social relatedness affects intrinsic motivation, which in turn relates to more active or passive learning behavior. As the social context plays a major role for basic need satisfaction, distance learning may impair basic need satisfaction and thus intrinsic motivation and learning behavior. The aim of this study was to investigate the relationship between basic need satisfaction and procrastination and persistence in the context of emergency distance learning during the COVID-19 pandemic in a cross-sectional study. We also investigated the mediating role of intrinsic motivation in this relationship. Furthermore, to test the universal importance of SDT for intrinsic motivation and learning behavior under these circumstances in different countries, we collected data in Europe, Asia and North America. A total of N = 15,462 participants from Albania, Austria, China, Croatia, Estonia, Finland, Germany, Iceland, Japan, Kosovo, Lithuania, Poland, Malta, North Macedonia, Romania, Sweden, and the US answered questions regarding perceived competence, autonomy, social relatedness, intrinsic motivation, procrastination, persistence, and sociodemographic background. Our results support SDT's claim of universality regarding the relation between basic psychological need fulfilment, intrinsic motivation, procrastination, and persistence. However, whereas perceived competence had the highest direct effect on procrastination and persistence, social relatedness was mainly influential via intrinsic motivation.", "doi": "10.1371/journal.pone.0257346", "pmid": "34613978", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-10408"}, {"db": "pmc", "key": "PMC8494346"}], "notes": [], "created": "2021-10-10T15:26:30.528Z", "modified": "2021-10-10T15:26:40.706Z"}, {"entity": "publication", "iuid": "68ef25c5e76d44af802d7349a8e8157c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68ef25c5e76d44af802d7349a8e8157c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68ef25c5e76d44af802d7349a8e8157c"}}, "title": "COVID-19 vaccination in patients with heart failure: a position paper of the Heart Failure Association of the European Society of Cardiology.", "authors": [{"family": "Rosano", "given": "Giuseppe", "initials": "G"}, {"family": "Jankowska", "given": "Ewa A", "initials": "EA"}, {"family": "Ray", "given": "Robin", "initials": "R"}, {"family": "Metra", "given": "Marco", "initials": "M"}, {"family": "Abdelhamid", "given": "Magdy", "initials": "M"}, {"family": "Adamopoulos", "given": "Stamatis", "initials": "S"}, {"family": "Anker", "given": "Stefan D", "initials": "SD"}, {"family": "Bayes-Genis", "given": "Antoni", "initials": "A"}, {"family": "Belenkov", "given": "Yuri", "initials": "Y"}, {"family": "Gal", "given": "Tuvia B", "initials": "TB"}, {"family": "B\u00f6hm", "given": "Michael", "initials": "M"}, {"family": "Chioncel", "given": "Ovidiu", "initials": "O"}, {"family": "Cohen-Solal", "given": "Alain", "initials": "A"}, {"family": "Farmakis", "given": "Dimitrios", "initials": "D"}, {"family": "Filippatos", "given": "Gerasimos", "initials": "G"}, {"family": "Gonz\u00e1lez", "given": "Arantxa", "initials": "A"}, {"family": "Gustafsson", "given": "Finn", "initials": "F"}, {"family": "Hill", "given": "Loreena", "initials": "L"}, {"family": "Jaarsma", "given": "Tiny", "initials": "T"}, {"family": "Jouhra", "given": "Fadi", "initials": "F"}, {"family": "Lainscak", "given": "Mitja", "initials": "M"}, {"family": "Lambrinou", "given": "Ekaterini", "initials": "E"}, {"family": "Lopatin", "given": "Yury", "initials": "Y"}, {"family": "Lund", "given": "Lars H", "initials": "LH"}, {"family": "Milicic", "given": "Davor", "initials": "D"}, {"family": "Moura", "given": "Brenda", "initials": "B"}, {"family": "Mullens", "given": "Wilfried", "initials": "W"}, {"family": "Piepoli", "given": "Massimo F", "initials": "MF"}, {"family": "Ponikowski", "given": "Piotr", "initials": "P"}, {"family": "Rakisheva", "given": "Amina", "initials": "A"}, {"family": "Ristic", "given": "Arsen", "initials": "A"}, {"family": "Savarese", "given": "Gianluigi", "initials": "G"}, {"family": "Seferovic", "given": "Petar", "initials": "P"}, {"family": "Senni", "given": "Michele", "initials": "M"}, {"family": "Thum", "given": "Thomas", "initials": "T"}, {"family": "Tocchetti", "given": "Carlo G", "initials": "CG"}, {"family": "Van Linthout", "given": "Sophie", "initials": "S"}, {"family": "Volterrani", "given": "Maurizio", "initials": "M"}, {"family": "Coats", "given": "Andrew J S", "initials": "AJS"}], "type": "journal article", "published": "2021-10-06", "journal": {"title": "Eur J Heart Fail", "issn": "1879-0844", "issn-l": "1388-9842"}, "abstract": "Patients with heart failure (HF) who contract SARS-CoV-2 infection are at a higher risk of cardiovascular and non-cardiovascular morbidity and mortality. Regardless of therapeutic attempts in COVID-19, vaccination remains the most promising global approach at present for controlling this disease. There are several concerns and misconceptions regarding the clinical indications, optimal mode of delivery, safety and efficacy of COVID-19 vaccines for patients with HF. This document provides guidance to all healthcare professionals regarding the implementation of a COVID-19 vaccination scheme in patients with HF. COVID-19 vaccination is indicated in all patients with HF, including those who are immunocompromised (e.g. after heart transplantation receiving immunosuppressive therapy) and with frailty syndrome. It is preferable to vaccinate against COVID-19 patients with HF in an optimal clinical state, which would include clinical stability, adequate hydration and nutrition, optimized treatment of HF and other comorbidities (including iron deficiency), but corrective measures should not be allowed to delay vaccination. Patients with HF who have been vaccinated against COVID-19 need to continue precautionary measures, including the use of facemasks, hand hygiene and social distancing. Knowledge on strategies preventing SARS-CoV-2 infection (including the COVID-19 vaccination) should be included in the comprehensive educational programmes delivered to patients with HF. This article is protected by copyright. All rights reserved.", "doi": "10.1002/ejhf.2356", "pmid": "34612556", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:28:10.061Z", "modified": "2021-10-10T15:28:10.071Z"}, {"entity": "publication", "iuid": "56c9f4f3d9104458b6a4725592079790", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56c9f4f3d9104458b6a4725592079790.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56c9f4f3d9104458b6a4725592079790"}}, "title": "Metabolic Perturbation Associated With COVID-19 Disease Severity and SARS-CoV-2 Replication.", "authors": [{"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Nordqvist", "given": "Hampus", "initials": "H"}, {"family": "Ambikan", "given": "Anoop T", "initials": "AT", "orcid": "0000-0002-5221-9085", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b14201e4cc547bd8b47d8c27bd0189d.json"}}, {"family": "Gupta", "given": "Soham", "initials": "S", "orcid": "0000-0003-1136-3010", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e94ad93c8263474ab2a9f46a82e763ad.json"}}, {"family": "Sperk", "given": "Maike", "initials": "M"}, {"family": "Svensson-Akusj\u00e4rvi", "given": "Sara", "initials": "S", "orcid": "0000-0002-1086-5409", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20ca29a0c3544bacbf5c44e60263f0a3.json"}}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "Benfeitas", "given": "Rui", "initials": "R", "orcid": "0000-0001-7972-0083", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88e286a997e8409193c9c8713d324f81.json"}}, {"family": "Saccon", "given": "Elisa", "initials": "E", "orcid": "0000-0003-3283-4432", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28cbb3510cbc4bf5b4db2bee1689467f.json"}}, {"family": "Ponnan", "given": "Sivasankaran Munusamy", "initials": "SM"}, {"family": "Rodriguez", "given": "Jimmy Esneider", "initials": "JE", "orcid": "0000-0002-6735-3332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/687f0a9fa4a94f1cb2d7c7bcf504a48d.json"}}, {"family": "Nikouyan", "given": "Negin", "initials": "N"}, {"family": "Odeh", "given": "Amani", "initials": "A"}, {"family": "Ahl\u00e9n", "given": "Gustaf", "initials": "G"}, {"family": "Asghar", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-9017-2206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0e95806bb4a4dca8363a6d9618c678d.json"}}, {"family": "S\u00e4llberg", "given": "Matti", "initials": "M"}, {"family": "Vesterbacka", "given": "Jan", "initials": "J"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "V\u00e9gv\u00e1ri", "given": "\u00c1kos", "initials": "\u00c1", "orcid": "0000-0002-1287-0906", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d68085d6c3b541afbca67e17b2c42cd7.json"}}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Treutiger", "given": "Carl Johan", "initials": "CJ"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "journal article", "published": "2021-10-05", "journal": {"title": "Mol Cell Proteomics", "issn": "1535-9484", "issn-l": null, "volume": "20", "issue": null, "pages": "100159"}, "abstract": "Viruses hijack host metabolic pathways for their replicative advantage. In this study, using patient-derived multiomics data and in vitro infection assays, we aimed to understand the role of key metabolic pathways that can regulate severe acute respiratory syndrome coronavirus-2 reproduction and their association with disease severity. We used multiomics platforms (targeted and untargeted proteomics and untargeted metabolomics) on patient samples and cell-line models along with immune phenotyping of metabolite transporters in patient blood cells to understand viral-induced metabolic modulations. We also modulated key metabolic pathways that were identified using multiomics data to regulate the viral reproduction in vitro. Coronavirus disease 2019 disease severity was characterized by increased plasma glucose and mannose levels. Immune phenotyping identified altered expression patterns of carbohydrate transporter, glucose transporter 1, in CD8+ T cells, intermediate and nonclassical monocytes, and amino acid transporter, xCT, in classical, intermediate, and nonclassical monocytes. In in vitro lung epithelial cell (Calu-3) infection model, we found that glycolysis and glutaminolysis are essential for virus replication, and blocking these metabolic pathways caused significant reduction in virus production. Taken together, we therefore hypothesized that severe acute respiratory syndrome coronavirus-2 utilizes and rewires pathways governing central carbon metabolism leading to the efflux of toxic metabolites and associated with disease severity. Thus, the host metabolic perturbation could be an attractive strategy to limit the viral replication and disease severity.", "doi": "10.1016/j.mcpro.2021.100159", "pmid": "34619366", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S1535-9476(21)00131-6"}, {"db": "pmc", "key": "PMC8490130"}], "notes": [], "created": "2021-03-08T14:54:26.783Z", "modified": "2022-02-16T07:35:24.059Z"}, {"entity": "publication", "iuid": "3af6dbea939b4957afb69291a136ea31", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3af6dbea939b4957afb69291a136ea31.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3af6dbea939b4957afb69291a136ea31"}}, "title": "High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19.", "authors": [{"family": "Lourda", "given": "Magda", "initials": "M", "orcid": "0000-0003-3155-1123", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09048dd72d384232932b004149b543e4.json"}}, {"family": "Dzidic", "given": "Majda", "initials": "M"}, {"family": "Hertwig", "given": "Laura", "initials": "L", "orcid": "0000-0002-1170-0948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbc76f6fbe8b4fcebfa928374618b304.json"}}, {"family": "Bergsten", "given": "Helena", "initials": "H"}, {"family": "Palma Medina", "given": "Laura M", "initials": "LM"}, {"family": "Sinha", "given": "Indranil", "initials": "I", "orcid": "0000-0002-2513-5927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/261f9a5460a64c1fb21331b6619b068d.json"}}, {"family": "Kvedaraite", "given": "Egle", "initials": "E"}, {"family": "Chen", "given": "Puran", "initials": "P", "orcid": "0000-0002-2890-0022", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d90f1cd607240b6bad38c32855b58d2.json"}}, {"family": "Muvva", "given": "Jagadeeswara R", "initials": "JR"}, {"family": "Gorin", "given": "Jean-Baptiste", "initials": "JB"}, {"family": "Cornillet", "given": "Martin", "initials": "M", "orcid": "0000-0001-7981-0927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20d0c2fd2be843668806a91d2d83104b.json"}}, {"family": "Emg\u00e5rd", "given": "Johanna", "initials": "J"}, {"family": "Moll", "given": "Kirsten", "initials": "K"}, {"family": "Garc\u00eda", "given": "Marina", "initials": "M", "orcid": "0000-0002-9130-3933", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5b109d7a54e4c05a48e0f21c4432be6.json"}}, {"family": "Maleki", "given": "Kimia T", "initials": "KT", "orcid": "0000-0001-5382-5477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c0313be527f49c0b41a37115a68408d.json"}}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Flodstr\u00f6m-Tullberg", "given": "Malin", "initials": "M"}, {"family": "Brighenti", "given": "Susanna", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J"}, {"family": "Malmberg", "given": "Karl-Johan", "initials": "KJ"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK", "orcid": "0000-0002-6275-0750", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61225c074353413bb0b19c43b555732a.json"}}, {"family": "Henter", "given": "Jan-Inge", "initials": "JI", "orcid": "0000-0002-0629-2126", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a88b3feb9554be1804f4836f2dc36de.json"}}, {"family": "Folkesson", "given": "Elin", "initials": "E"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S", "orcid": "0000-0002-2446-4323", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/363ff940d9c64575a11bd45372927b2c.json"}}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Aleman", "given": "Soo", "initials": "S", "orcid": "0000-0003-0461-4870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b0edb2db8d840989936f67047ce91de.json"}}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-8801-3169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37509c3832244b019b91a1fe2cbe183e.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG", "orcid": "0000-0003-0908-7387", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48a59f01e46c41038301a586178e8e2a.json"}}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4691d38f3268433696d7c65ea235a12b.json"}}, {"family": "Svensson", "given": "Mattias", "initials": "M", "orcid": "0000-0003-1695-7934", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7ae76a597164d02b4fcfadfe53c48a3.json"}}, {"family": "Ponzetta", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3224-802X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8d6bca49dc24e558ca8f0b3637d7702.json"}}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A", "orcid": "0000-0001-9372-1795", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5eb1e61066d6451c920200f83e99cb9e.json"}}, {"family": "Chambers", "given": "Benedict J", "initials": "BJ", "orcid": "0000-0003-0437-8441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6089d99ec42d475f8f57c8d8cc1ff1de.json"}}, {"family": "Karolinska KI/K COVID-19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-10-05", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "issn-l": "0027-8424", "volume": "118", "issue": "40", "pages": null}, "abstract": "Since the outset of the COVID-19 pandemic, increasing evidence suggests that the innate immune responses play an important role in the disease development. A dysregulated inflammatory state has been proposed as a key driver of clinical complications in COVID-19, with a potential detrimental role of granulocytes. However, a comprehensive phenotypic description of circulating granulocytes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients is lacking. In this study, we used high-dimensional flow cytometry for granulocyte immunophenotyping in peripheral blood collected from COVID-19 patients during acute and convalescent phases. Severe COVID-19 was associated with increased levels of both mature and immature neutrophils, and decreased counts of eosinophils and basophils. Distinct immunotypes were evident in COVID-19 patients, with altered expression of several receptors involved in activation, adhesion, and migration of granulocytes (e.g., CD62L, CD11a/b, CD69, CD63, CXCR4). Paired sampling revealed recovery and phenotypic restoration of the granulocytic signature in the convalescent phase. The identified granulocyte immunotypes correlated with distinct sets of soluble inflammatory markers, supporting pathophysiologic relevance. Furthermore, clinical features, including multiorgan dysfunction and respiratory function, could be predicted using combined laboratory measurements and immunophenotyping. This study provides a comprehensive granulocyte characterization in COVID-19 and reveals specific immunotypes with potential predictive value for key clinical features associated with COVID-19.", "doi": "10.1073/pnas.2109123118", "pmid": "34548411", "labels": {"Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2109123118"}], "notes": [], "created": "2021-02-02T11:37:31.818Z", "modified": "2021-09-23T05:17:12.682Z"}, {"entity": "publication", "iuid": "f4a45618e0384dfab5459663691b324b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f4a45618e0384dfab5459663691b324b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f4a45618e0384dfab5459663691b324b"}}, "title": "Establishing a COVID-19 pandemic severity assessment surveillance system in Ireland.", "authors": [{"family": "Domegan", "given": "Lisa", "initials": "L", "orcid": "0000-0002-7483-6703", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b12d1831028479eb6303b6c8d348ccb.json"}}, {"family": "Garvey", "given": "Patricia", "initials": "P"}, {"family": "McEnery", "given": "Maeve", "initials": "M"}, {"family": "Fiegenbaum", "given": "Rachel", "initials": "R"}, {"family": "Brabazon", "given": "Elaine", "initials": "E"}, {"family": "Quintyne", "given": "Keith Ian", "initials": "KI"}, {"family": "O'Connor", "given": "Lois", "initials": "L"}, {"family": "Cuddihy", "given": "John", "initials": "J"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}], "type": "journal article", "published": "2021-10-05", "journal": {"title": "Influenza Other Respir Viruses", "issn": "1750-2659", "issn-l": null}, "abstract": "We developed a COVID-19 pandemic severity assessment (PSA) monitoring system in Ireland, in order to inform and improve public health preparedness, response and recovery. The system based on the World Health Organization (WHO) Pandemic Influenza Severity Assessment (PISA) project included a panel of surveillance parameters for the following indicators: transmissibility, impact and disease severity. Age-specific thresholds were established for each parameter and data visualised using heat maps. The findings from the first pandemic wave in Ireland have shown that the WHO PISA system can be adapted for COVID-19, providing a standardised tool for early warning and monitoring pandemic severity.", "doi": "10.1111/irv.12890", "pmid": "34609049", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:29:42.777Z", "modified": "2021-10-10T15:29:42.827Z"}, {"entity": "publication", "iuid": "539c23ed279c4d11a59b88fe8519bbc5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/539c23ed279c4d11a59b88fe8519bbc5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/539c23ed279c4d11a59b88fe8519bbc5"}}, "title": "Associations of Disease-Modifying Therapies With COVID-19 Severity in Multiple Sclerosis.", "authors": [{"family": "Simpson-Yap", "given": "Steve", "initials": "S", "orcid": "0000-0001-6521-3056", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/845cbea3a2f64b9f880a43d6cc8cdb09.json"}}, {"family": "De Brouwer", "given": "Edward", "initials": "E"}, {"family": "Kalincik", "given": "Tomas", "initials": "T", "orcid": "0000-0003-3778-1376", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d57266f045d648a8b749b6496f4b2fc5.json"}}, {"family": "Rijke", "given": "Nick", "initials": "N"}, {"family": "Hillert", "given": "Jan A", "initials": "JA"}, {"family": "Walton", "given": "Clare", "initials": "C"}, {"family": "Edan", "given": "Gilles", "initials": "G"}, {"family": "Moreau", "given": "Yves", "initials": "Y"}, {"family": "Spelman", "given": "Tim", "initials": "T"}, {"family": "Geys", "given": "Lotte", "initials": "L"}, {"family": "Parciak", "given": "Tina", "initials": "T", "orcid": "0000-0002-1989-3641", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19f442e54aa847db9aeb8df80b28bc2f.json"}}, {"family": "Gautrais", "given": "Clement", "initials": "C"}, {"family": "Lazovski", "given": "Nikola", "initials": "N"}, {"family": "Pirmani", "given": "Ashkan", "initials": "A", "orcid": "0000-0003-4549-1002", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d72bbbd407ef4f5387e6653e68e127fc.json"}}, {"family": "Ardeshirdavanai", "given": "Amin", "initials": "A", "orcid": "0000-0002-7226-7324", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f886fb5d880b48828dd8f72c57deb510.json"}}, {"family": "Forsberg", "given": "Lars", "initials": "L", "orcid": "0000-0002-3536-1813", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b57c570dfe5e489c98831771524f0267.json"}}, {"family": "Glaser", "given": "Anna", "initials": "A"}, {"family": "McBurney", "given": "Robert", "initials": "R", "orcid": "0000-0003-1747-1004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2f7c9449433431198c390f39cf1d930.json"}}, {"family": "Schmidt", "given": "Hollie", "initials": "H"}, {"family": "Bergmann", "given": "Arnfin B", "initials": "AB"}, {"family": "Braune", "given": "Stefan", "initials": "S"}, {"family": "Stahmann", "given": "Alexander", "initials": "A", "orcid": "0000-0001-5308-105X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/da733ad3878f45738e211c7317b3edda.json"}}, {"family": "Middleton", "given": "Rodden", "initials": "R", "orcid": "0000-0002-2130-4420", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7adf9663f3ea4db7b2bfc70b724ad309.json"}}, {"family": "Salter", "given": "Amber", "initials": "A", "orcid": "0000-0002-1088-110X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e108ab0c847c4d5b8e66af7cfb6619ec.json"}}, {"family": "Fox", "given": "Robert J", "initials": "RJ", "orcid": "0000-0002-4263-3717", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c20b76857014771847ad29d94572445.json"}}, {"family": "van der Walt", "given": "Anneke", "initials": "A", "orcid": "0000-0002-4278-7003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4636e8ba06d94593929e1c30619cc500.json"}}, {"family": "Butzkueven", "given": "Helmut", "initials": "H"}, {"family": "Alroughani", "given": "Raed", "initials": "R"}, {"family": "Ozakbas", "given": "Serkan", "initials": "S"}, {"family": "Rojas", "given": "Juan I", "initials": "JI"}, {"family": "van der Mei", "given": "Ingrid", "initials": "I"}, {"family": "Nag", "given": "Nupur", "initials": "N", "orcid": "0000-0002-0271-0781", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e143288e60634d7aae97a2db6c73350a.json"}}, {"family": "Ivanov", "given": "Rumen", "initials": "R"}, {"family": "Sciascia do Olival", "given": "Guilherme", "initials": "G", "orcid": "0000-0002-2717-7522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67a109d6755d46528b376eab394b3f44.json"}}, {"family": "Dias", "given": "Alice Estavo", "initials": "AE"}, {"family": "Magyari", "given": "Melinda", "initials": "M", "orcid": "0000-0002-0972-5222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4138641b9754548a434173a3f677e4a.json"}}, {"family": "Brum", "given": "Doralina", "initials": "D"}, {"family": "Mendes", "given": "Maria Fernanda", "initials": "MF"}, {"family": "Alonso", "given": "Ricardo N", "initials": "RN"}, {"family": "Nicholas", "given": "Richard S", "initials": "RS"}, {"family": "Bauer", "given": "Johana", "initials": "J"}, {"family": "Chertcoff", "given": "An\u00edbal Sebasti\u00e1n", "initials": "AS"}, {"family": "Zabalza", "given": "Anna", "initials": "A", "orcid": "0000-0003-3860-5251", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f24a8041d09442178e1f1f007f20c3e5.json"}}, {"family": "Arrambide", "given": "Georgina", "initials": "G", "orcid": "0000-0002-2657-5510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45c169a840fe487e8ed7b286e6c3708f.json"}}, {"family": "Fidao", "given": "Alex", "initials": "A"}, {"family": "Comi", "given": "Giancarlo", "initials": "G"}, {"family": "Peeters", "given": "Liesbet", "initials": "L"}], "type": "journal article", "published": "2021-10-05", "journal": {"title": "Neurology", "issn": "1526-632X", "issn-l": "0028-3878"}, "abstract": "People with multiple sclerosis (MS) are a vulnerable group for severe COVID- 19, particularly those taking immunosuppressive disease-modifying therapies (DMTs). We examined the characteristics of COVID-19 severity in an international sample of people with MS.\n\nData from 12 data-sources in 28 countries were aggregated (sources could include patients from 1-12 countries). Demographic (age, sex), clinical (MS-phenotype, disability), and DMT (untreated, alemtuzumab, cladribine, dimethyl-fumarate, glatiramer acetate, interferon, natalizumab, ocrelizumab, rituximab, siponimod, other DMTs) covariates were queried, alongside COVID-19 severity outcomes, hospitalisation, ICU admission, requiring artificial ventilation, and death. Characteristics of outcomes were assessed in patients with suspected/confirmed COVID-19 using multilevel mixed-effects logistic regression, adjusted for age, sex, MS-phenotype, and EDSS.\n\n657(28.1%) with suspected and 1,683(61.9%) with confirmed COVID-19 were analysed. Among suspected+confirmed and confirmed-only COVID-19, 20.9% and 26.9% were hospitalised, 5.4% and 7.2% were admitted to ICU, 4.1% and 5.4% required artificial ventilation, and 3.2% and 3.9% died. Older age, progressive MS-phenotype, and higher disability were associated with worse COVID-19 outcomes. Compared to dimethyl-fumarate, ocrelizumab and rituximab were associated with hospitalisation (aOR=1.56,95%CI=1.01- 2.41; aOR=2.43,95%CI=1.48-4.02) and ICU admission (aOR=2.30,95%CI=0.98-5.39;aOR=3.93,95%CI=1.56-9.89), though only rituximab was associated with higher risk of artificial ventilation (aOR=4.00,95%CI=1.54-10.39). Compared to pooled other DMTs, ocrelizumab and rituximab were associated with hospitalisation (aOR=1.75,95%CI=1.29- 2.38; aOR=2.76,95%CI=1.87-4.07) and ICU admission (aOR=2.55,95%CI=1.49-4.36;aOR=4.32,95%CI=2.27-8.23) but only rituximab with artificial ventilation (aOR=6.15,95%CI=3.09-12.27). Compared to natalizumab, ocrelizumab and rituximab wereassociated with hospitalisation (aOR=1.86,95%CI=1.13-3.07; aOR=2.88,95%CI=1.68-4.92) and ICU admission (aOR=2.13,95%CI=0.85-5.35; aOR=3.23,95%CI=1.17-8.91), but only rituximab with ventilation (aOR=5.52,95%CI=1.71-17.84). Importantly, associations persisted on restriction to confirmed COVID-19 cases. No associations were observed between DMTs and death. Stratification by age, MS-phenotype, and EDSS found no indications that DMT associations with COVID-19 severity reflected differential DMT allocation by underlying COVID-19 severity.\n\nUsing the largest cohort of people with MS and COVID-19 available, we demonstrated consistent associations of rituximab with increased risk of hospitalisation, ICU admission, and requiring artificial ventilation, and ocrelizumab with hospitalisation and ICU admission. Despite the study's cross-sectional design, the internal and external consistency of these results with prior studies suggests rituximab/ocrelizumab use may be a risk factor for more severe COVID-19.", "doi": "10.1212/WNL.0000000000012753", "pmid": "34610987", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "WNL.0000000000012753"}], "notes": [], "created": "2021-10-10T15:28:34.500Z", "modified": "2021-10-10T15:28:34.892Z"}, {"entity": "publication", "iuid": "0d721ff011d1404d8b5d41856ba512d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d721ff011d1404d8b5d41856ba512d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d721ff011d1404d8b5d41856ba512d4"}}, "title": "Adverse events of special interest for COVID-19 vaccines - background incidences vary by sex, age and time period and are affected by the pandemic", "authors": [{"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Vanfleteren", "given": "Lowie E G W", "initials": "LEGW"}, {"family": "Hammar", "given": "Niklas", "initials": "N"}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Kirui", "given": "Brian K", "initials": "BK"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "posted-content", "published": "2021-10-05", "journal": {"title": "MedRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.10.04.21263507", "pmid": null, "labels": {"Category: Health": null, "Research Area: Vaccine": null, "Funder: KAW/SciLifeLab": null, "Type: Preprint": null, "Topics: Register-based research": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-10-21T05:51:25.592Z", "modified": "2022-02-06T17:44:13.656Z"}, {"entity": "publication", "iuid": "ee65ea75cad04e3e90c520ef967bb5f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee65ea75cad04e3e90c520ef967bb5f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee65ea75cad04e3e90c520ef967bb5f8"}}, "title": "Assessing relative COVID-19 mortality during the second wave: a prospective Swiss population-based study.", "authors": [{"family": "Siegfried", "given": "Sandra", "initials": "S", "orcid": "0000-0002-7312-1001", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5e6f621879e43d589a82fae0ae5d7d6.json"}}, {"family": "Bopp", "given": "Matthias", "initials": "M"}, {"family": "G\u00fcnthard", "given": "Huldrych", "initials": "H"}, {"family": "Keiser", "given": "Olivia", "initials": "O"}, {"family": "Weibull", "given": "Caroline E", "initials": "CE"}, {"family": "Crowther", "given": "Michael", "initials": "M"}, {"family": "Hothorn", "given": "Torsten", "initials": "T", "orcid": "0000-0001-8301-0471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a9fe39a0c764477ab308928f6e8228b.json"}}], "type": "journal article", "published": "2021-10-04", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "10", "pages": "e051164", "issn-l": "2044-6055"}, "abstract": "During the first COVID-19 wave in Switzerland, relative mortality was at least eight times higher compared with the uninfected general population. We aimed to assess sex-specific and age-specific relative mortality associated with a SARS-CoV-2 diagnosis during the second wave.\n\nProspective population-based study.\n\nIndividuals testing positive for SARS-CoV-2 after the start of the second wave on 1 October 2020 were followed up until death or administrative censoring on 31 December 2020.\n\n5 179 740 inhabitants of Switzerland in fall 2018 aged 35-95 years (without COVID-19) and 257 288 persons tested positive for SARS-CoV-2 by PCR or antigen testing during the second wave.\n\nThe planned outcome measure was time to death from any cause, measured from the date of a SARS-CoV-2 diagnosis or 1 October in the general population. Information on confirmed SARS-CoV-2 diagnoses and deaths was matched by calendar time with the all-cause mortality of the general Swiss population of 2018. Proportional hazards models were used to estimate sex-specific and age-specific mortality rates and probabilities of death within 60 days.\n\nThe risk of death for individuals tested positive for SARS-CoV-2 in the second wave in Switzerland increased at least sixfold compared with the general population. HRs, reflecting the risk attributable to a SARS-CoV-2 infection, were higher for men (1.40, 95% CI 1.29 to 1.52) and increased for each additional year of age (1.01, 95% CI 1.01 to 1.02). COVID-19 mortality was reduced by at least 20% compared with the first wave in spring 2020.\n\nGeneral mortality patterns, increased for men and older persons, were similar in spring and in fall. Absolute and relative COVID-19 mortality was smaller in fall.\n\nThe protocol for this study was registered on 3 December 2020 at https://osf.io/gbd6r.", "doi": "10.1136/bmjopen-2021-051164", "pmid": "34607868", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-051164"}, {"db": "pmc", "key": "PMC8491006"}], "notes": [], "created": "2021-10-10T15:30:25.734Z", "modified": "2021-10-10T15:32:26.473Z"}, {"entity": "publication", "iuid": "04ce8b77317e40369326ca286363bd5b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/04ce8b77317e40369326ca286363bd5b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/04ce8b77317e40369326ca286363bd5b"}}, "title": "ATG and Post-transplant Cyclophosphamide predisposes to inferior outcome when using cryopreserved stem cell grafts.", "authors": [{"family": "Novitzky-Basso", "given": "Igor", "initials": "I", "orcid": "0000-0003-3748-3117", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6f8f01041fa4649b5f3b11d44bae033.json"}}, {"family": "Remberger", "given": "Mats", "initials": "M", "orcid": "0000-0003-0520-4312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/133deb67baba4c55ac292259d1a4500e.json"}}, {"family": "Chen", "given": "Carol", "initials": "C"}, {"family": "Pasi\u0107", "given": "Ivan", "initials": "I", "orcid": "0000-0001-7595-0113", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6f675a4dd4842c496475438e9ce40f5.json"}}, {"family": "Lam", "given": "Wilson", "initials": "W"}, {"family": "Law", "given": "Arjun", "initials": "A"}, {"family": "Gerbitz", "given": "Armin", "initials": "A"}, {"family": "Viswabandya", "given": "Auro", "initials": "A"}, {"family": "Lipton", "given": "Jeffrey H", "initials": "JH", "orcid": "0000-0001-7391-7168", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6366fdc4b85a4d4e99676639ac8aa491.json"}}, {"family": "Kim", "given": "Dennis D", "initials": "DD"}, {"family": "Kumar", "given": "Rajat", "initials": "R"}, {"family": "Mattsson", "given": "Jonas", "initials": "J"}, {"family": "Michelis", "given": "Fotios V", "initials": "FV", "orcid": "0000-0003-2956-0848", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/85171f94f0cb4bb598fa1d6dba89aa6c.json"}}], "type": "journal article", "published": "2021-10-04", "journal": {"title": "Eur J Haematol", "issn": "1600-0609", "issn-l": null}, "abstract": "During 2020, the concurrent novel COVID-19 pandemic lead to widespread cryopreservation of allogeneic HCT grafts based on NMDP and EBMT recommendations, in order to secure grafts before the start of conditioning chemotherapy. We sought to examine the impact of this change in practice on patient outcomes. We analyzed the outcomes of 483 patients who received HSCT between August 2017 and August 2020, at Princess Margaret Cancer Centre, Canada, in the retrospective study, comparing the outcomes between those who received cryopreserved or fresh peripheral blood stem cell grafts. Overall compared to those who received fresh grafts (n=348), patients who received cryopreserved grafts (n=135) had reduced survival and GRFS, reduced incidence of chronic GvHD, delay in neutrophil engraftment and higher graft failure, with no significant difference in relapse incidence or acute GvHD. However, recipients of cryopreserved matched related donor HSCT showed significantly worse OS, NRM, GRFS compared to fresh grafts. Multivariable analysis of the entire cohort showed significant impact of cryopreservation on OS, relapse, cGvHD, graft failure and GRFS. We conclude that cryopreservation was associated with inferior outcomes post-HSCT, possibly due to the combination of ATG and post-transplant cyclophosphamide impacting differential tolerance to cryopreservation on components of the stem cell graft; further studies are warranted to elucidate mechanisms for this observation.", "doi": "10.1111/ejh.13714", "pmid": "34606661", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:55:56.022Z", "modified": "2021-10-11T17:55:56.247Z"}, {"entity": "publication", "iuid": "fa05a20338ca42da8ff871da200388c4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa05a20338ca42da8ff871da200388c4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa05a20338ca42da8ff871da200388c4"}}, "title": "Pooled testing for SARS-CoV-2, options for efficiency at scale.", "authors": [{"family": "Reilly", "given": "Marie", "initials": "M"}, {"family": "Chohan", "given": "Bhavna", "initials": "B"}], "type": "journal article", "published": "2021-10-01", "journal": {"title": "Bull World Health Organ", "issn": "1564-0604", "volume": "99", "issue": "10", "pages": "708-714", "issn-l": null}, "abstract": "Widescale testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is recognized as a key element of surveillance and outbreak control in the coronavirus disease 2019 (COVID-19) pandemic. The practical challenges, however, have often led to testing only symptomatic individuals and their close contacts. As many countries plan for a cautious relaxation of social restrictions, more effective approaches for widescale testing are increasingly important. Early in the COVID-19 pandemic, laboratories in several countries demonstrated the feasibility of detecting SARS-CoV-2 infection by pooled testing, which combines the specimens from several individuals. Since no further testing is needed for individuals in a negative pool, there is potential for greater efficiency of testing. Despite validations of the accuracy of the results and the efficiency in testing specific groups, the benefits of pooling are less acknowledged as a population surveillance strategy that can detect new disease outbreaks without posing restrictions on entire societies. Pooling specimens from natural clusters, such as school classes, sports teams, workplace colleagues and other social networks, would enable timely and cost-effective widescale testing for SARS-CoV-2. The initial result would be readily translatable into action in terms of quarantine and isolation policies. Clusters of uninfected individuals would be quickly identified and immediate local lockdown of positive clusters would be the appropriate and sufficient action while retesting those individuals. By adapting to the social networks of a population, pooled testing offers a cost-efficient surveillance system that is synchronized with quarantine policies that are rational, risk-based and equitable.", "doi": "10.2471/BLT.20.283093", "pmid": "34621088", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Other": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "BLT.20.283093"}, {"db": "pmc", "key": "PMC8477423"}], "notes": [], "created": "2021-10-10T15:09:06.074Z", "modified": "2021-10-10T15:09:06.098Z"}, {"entity": "publication", "iuid": "c702b47064944448a7ec4b0082312820", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c702b47064944448a7ec4b0082312820.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c702b47064944448a7ec4b0082312820"}}, "title": "Physical Activity and Perceived Health in People With Parkinson Disease During the First Wave of Covid-19 Pandemic: A Cross-sectional Study From Sweden.", "authors": [{"family": "Leavy", "given": "Breiffni", "initials": "B"}, {"family": "Hagstr\u00f6mer", "given": "Maria", "initials": "M"}, {"family": "Conradsson", "given": "David Moulaee", "initials": "DM"}, {"family": "Franz\u00e9n", "given": "Erika", "initials": "E"}], "type": "journal article", "published": "2021-10-01", "journal": {"title": "J Neurol Phys Ther", "issn": "1557-0584", "issn-l": null, "volume": "45", "issue": "4", "pages": "266-272"}, "abstract": "People with Parkinson disease (PD) are known to be at risk of physical inactivity and may therefore be especially vulnerable to negative health outcomes during the COVID-19 pandemic due to social distancing recommendations.\r\n\r\nTo investigate sensor-derived physical activity and perceived health of people with PD during the first wave of the COVID-19 pandemic, as well as the factors associated with these outcomes.\r\n\r\nPhysical activity was measured over 7 days using the Actigraph GT3x accelerometer. Data were collected regarding perceived health status and physical activity habits, as well as rehabilitation attendance during the pandemic. Multiple linear and logistic regression analyses were used to identify factors associated with physical activity and perceived changes in health.\r\n\r\nOf 89 participants, a majority (67%) reported a pandemic-related reduction in exercise habits. Women more commonly reported a reduction in scheduled exercise and cancelled rehabilitation than men. Study participants took on average 5876 \u00b1 3180 steps per day. In the multivariate analysis, female gender, being 70 years of age and older, and greater reported mobility problems were associated with being less physically active. A pandemic-induced deterioration in health was reported by 42% and women were 5 times more likely than men to do so (odds ratio: 5.12, 95% confidence interval, 1.87-15.03; P = 0.002).\r\n\r\nDespite a pandemic-related reduction in reported exercise habits and rehabilitation, the participants in this Swedish sample were relatively physically active. However, women were less active at moderate-vigorous levels and were at greater risk of deterioration in perceived health during this time.Video Abstract available for more insight from the authors (see the Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A359).", "doi": "10.1097/NPT.0000000000000372", "pmid": "34369451", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "01253086-900000000-99717"}, {"db": "ClinicalTrials.gov", "key": "NCT03213873"}], "notes": [], "created": "2021-08-11T14:34:18.812Z", "modified": "2022-02-17T10:23:22.720Z"}, {"entity": "publication", "iuid": "88edfc6421854b69bb11ce43ab061062", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/88edfc6421854b69bb11ce43ab061062.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/88edfc6421854b69bb11ce43ab061062"}}, "title": "Low-quality employment trajectories and risk of common mental disorders, substance use disorders and suicide attempt: a longitudinal study of the Swedish workforce.", "authors": [{"family": "Jonsson", "given": "Johanna", "initials": "J"}, {"family": "Muntaner", "given": "Carles", "initials": "C"}, {"family": "Bodin", "given": "Theo", "initials": "T"}, {"family": "Alderling", "given": "Magnus", "initials": "M"}, {"family": "Rebeka", "given": "Rebeka", "initials": "R"}, {"family": "Burstr\u00f6m", "given": "Bo", "initials": "B"}, {"family": "Davis", "given": "Letitia", "initials": "L"}, {"family": "Gunn", "given": "Virginia", "initials": "V"}, {"family": "Hemmingsson", "given": "Tomas", "initials": "T"}, {"family": "Juli\u00e0", "given": "Mireia", "initials": "M"}, {"family": "Kjellberg", "given": "Katarina", "initials": "K"}, {"family": "Kreshpaj", "given": "Bertina", "initials": "B"}, {"family": "Orellana", "given": "Cecilia", "initials": "C"}, {"family": "Padrosa", "given": "Eva", "initials": "E"}, {"family": "Wegman", "given": "David H", "initials": "DH"}, {"family": "Matilla-Santander", "given": "Nuria", "initials": "N"}], "type": "journal article", "published": "2021-10-01", "journal": {"title": "Scand J Work Environ Health", "issn": "1795-990X", "volume": "47", "issue": "7", "pages": "509-520", "issn-l": null}, "abstract": "High-quality longitudinal evidence exploring the mental health risk associated with low-quality employment trajectories is scarce. We therefore aimed to investigate the risk of being diagnosed with common mental disorders, substance use disorders, or suicide attempt according to low-quality employment trajectories.\n\nA longitudinal register-study based on the working population of Sweden (N=2 743 764). Employment trajectories (2005-2009) characterized by employment quality and pattern (constancy, fluctuation, mobility) were created. Hazard ratios (HR) were estimated using Cox proportional hazards regression models for first incidence (2010-2017) diagnosis of common mental disorders, substance use disorders and suicide attempt as dependent on employment trajectories.\n\nWe identified 21 employment trajectories, 10 of which were low quality (21%). With the exception of constant solo self-employment, there was an increased risk of common mental disorders (HR 1.07-1.62) and substance use disorders (HR 1.05-2.19) for all low-quality trajectories. Constant solo self-employment increased the risk for substance use disorders among women, while it reduced the risk of both disorders for men. Half of the low-quality trajectories were associated with a risk increase of suicide attempt (HR 1.08-1.76).\n\nLow-quality employment trajectories represent risk factors for mental disorders and suicide attempt in Sweden, and there might be differential effects according to sex - especially in terms of self-employment. Policies ensuring and maintaining high-quality employment characteristics over time are imperative. Similar prospective studies are needed, also in other contexts, which cover the effects of the Covid-19 pandemic as well as the mechanisms linking employment trajectories with mental health.", "doi": "10.5271/sjweh.3978", "pmid": "34397098", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "3978"}], "notes": [], "created": "2021-08-17T06:41:56.740Z", "modified": "2021-11-18T13:35:17.405Z"}, {"entity": "publication", "iuid": "4f98608ce2d04e9c870261c3e8afcbb2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4f98608ce2d04e9c870261c3e8afcbb2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4f98608ce2d04e9c870261c3e8afcbb2"}}, "title": "Association Between Tumor Necrosis Factor Inhibitors and the Risk of Hospitalization or Death Among Patients With Immune-Mediated Inflammatory Disease and COVID-19.", "authors": [{"family": "Izadi", "given": "Zara", "initials": "Z"}, {"family": "Brenner", "given": "Erica J", "initials": "EJ"}, {"family": "Mahil", "given": "Satveer K", "initials": "SK"}, {"family": "Dand", "given": "Nick", "initials": "N"}, {"family": "Yiu", "given": "Zenas Z N", "initials": "ZZN"}, {"family": "Yates", "given": "Mark", "initials": "M"}, {"family": "Ungaro", "given": "Ryan C", "initials": "RC"}, {"family": "Zhang", "given": "Xian", "initials": "X"}, {"family": "Agrawal", "given": "Manasi", "initials": "M"}, {"family": "Colombel", "given": "Jean-Frederic", "initials": "JF"}, {"family": "Gianfrancesco", "given": "Milena A", "initials": "MA"}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL"}, {"family": "Strangfeld", "given": "Anja", "initials": "A"}, {"family": "Carmona", "given": "Loreto", "initials": "L"}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S"}, {"family": "Klingberg", "given": "Eva", "initials": "E"}, {"family": "Cuomo", "given": "Giovanna", "initials": "G"}, {"family": "Caprioli", "given": "Marta", "initials": "M"}, {"family": "Cruz-Machado", "given": "Ana Rita", "initials": "AR"}, {"family": "Mazeda Pereira", "given": "Ana Carolina", "initials": "AC"}, {"family": "Hasseli", "given": "Rebecca", "initials": "R"}, {"family": "Pfeil", "given": "Alexander", "initials": "A"}, {"family": "Lorenz", "given": "Hanns-Martin", "initials": "HM"}, {"family": "Hoyer", "given": "Bimba Franziska", "initials": "BF"}, {"family": "Trupin", "given": "Laura", "initials": "L"}, {"family": "Rush", "given": "Stephanie", "initials": "S"}, {"family": "Katz", "given": "Patricia", "initials": "P"}, {"family": "Schmajuk", "given": "Gabriela", "initials": "G"}, {"family": "Jacobsohn", "given": "Lindsay", "initials": "L"}, {"family": "Seet", "given": "Andrea M", "initials": "AM"}, {"family": "Al Emadi", "given": "Samar", "initials": "S"}, {"family": "Wise", "given": "Leanna", "initials": "L"}, {"family": "Gilbert", "given": "Emily L", "initials": "EL"}, {"family": "Duarte-Garc\u00eda", "given": "Al\u00ed", "initials": "A"}, {"family": "Valenzuela-Almada", "given": "Maria O", "initials": "MO"}, {"family": "Isnardi", "given": "Carolina A", "initials": "CA"}, {"family": "Quintana", "given": "Rosana", "initials": "R"}, {"family": "Soriano", "given": "Enrique R", "initials": "ER"}, {"family": "Hsu", "given": "Tiffany Y-T", "initials": "TY"}, {"family": "D'Silva", "given": "Kristin M", "initials": "KM"}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA"}, {"family": "Patel", "given": "Naomi J", "initials": "NJ"}, {"family": "Xavier", "given": "Ricardo Machado", "initials": "RM"}, {"family": "Marques", "given": "Claudia Diniz Lopes", "initials": "CDL"}, {"family": "Kakehasi", "given": "Adriana Maria", "initials": "AM"}, {"family": "Flipo", "given": "Ren\u00e9-Marc", "initials": "RM"}, {"family": "Claudepierre", "given": "Pascal", "initials": "P"}, {"family": "Cantagrel", "given": "Alain", "initials": "A"}, {"family": "Goupille", "given": "Philippe", "initials": "P"}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Costello", "given": "Wendy", "initials": "W"}, {"family": "Grainger", "given": "Rebecca", "initials": "R"}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS"}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Sufka", "given": "Paul", "initials": "P"}, {"family": "Robinson", "given": "Philip C", "initials": "PC"}, {"family": "Machado", "given": "Pedro M", "initials": "PM"}, {"family": "Griffiths", "given": "Christopher E M", "initials": "CEM"}, {"family": "Barker", "given": "Jonathan N", "initials": "JN"}, {"family": "Smith", "given": "Catherine H", "initials": "CH"}, {"family": "Yazdany", "given": "Jinoos", "initials": "J"}, {"family": "Kappelman", "given": "Michael D", "initials": "MD"}, {"family": "Psoriasis Patient Registry for Outcomes, Therapy and Epidemiology of COVID-19 Infection (PsoProtect); the Secure Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease (SECURE-IBD); and the COVID-19 Global Rheumatology Allianc", "given": "", "initials": ""}, {"family": "Psoriasis Patient Registry for Outcomes, Therapy and Epidemiology of COVID-19 Infection (PsoProtect); the Secure Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease (SECURE-IBD); and the COVID-19 Global Rheumatology Alliance (GRA)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-10-01", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "volume": "4", "issue": "10", "pages": "e2129639", "issn-l": null}, "abstract": "Although tumor necrosis factor (TNF) inhibitors are widely prescribed globally because of their ability to ameliorate shared immune pathways across immune-mediated inflammatory diseases (IMIDs), the impact of COVID-19 among individuals with IMIDs who are receiving TNF inhibitors remains insufficiently understood.\n\nTo examine the association between the receipt of TNF inhibitor monotherapy and the risk of COVID-19-associated hospitalization or death compared with other commonly prescribed immunomodulatory treatment regimens among adult patients with IMIDs.\n\nThis cohort study was a pooled analysis of data from 3 international COVID-19 registries comprising individuals with rheumatic diseases, inflammatory bowel disease, and psoriasis from March 12, 2020, to February 1, 2021. Clinicians directly reported COVID-19 outcomes as well as demographic and clinical characteristics of individuals with IMIDs and confirmed or suspected COVID-19 using online data entry portals. Adults (age \u226518 years) with a diagnosis of inflammatory arthritis, inflammatory bowel disease, or psoriasis were included.\n\nTreatment exposure categories included TNF inhibitor monotherapy (reference treatment), TNF inhibitors in combination with methotrexate therapy, TNF inhibitors in combination with azathioprine/6-mercaptopurine therapy, methotrexate monotherapy, azathioprine/6-mercaptopurine monotherapy, and Janus kinase (Jak) inhibitor monotherapy.\n\nThe main outcome was COVID-19-associated hospitalization or death. Registry-level analyses and a pooled analysis of data across the 3 registries were conducted using multilevel multivariable logistic regression models, adjusting for demographic and clinical characteristics and accounting for country, calendar month, and registry-level correlations.\n\nA total of 6077 patients from 74 countries were included in the analyses; of those, 3215 individuals (52.9%) were from Europe, 3563 individuals (58.6%) were female, and the mean (SD) age was 48.8 (16.5) years. The most common IMID diagnoses were rheumatoid arthritis (2146 patients [35.3%]) and Crohn disease (1537 patients [25.3%]). A total of 1297 patients (21.3%) were hospitalized, and 189 patients (3.1%) died. In the pooled analysis, compared with patients who received TNF inhibitor monotherapy, higher odds of hospitalization or death were observed among those who received a TNF inhibitor in combination with azathioprine/6-mercaptopurine therapy (odds ratio [OR], 1.74; 95% CI, 1.17-2.58; P = .006), azathioprine/6-mercaptopurine monotherapy (OR, 1.84; 95% CI, 1.30-2.61; P = .001), methotrexate monotherapy (OR, 2.00; 95% CI, 1.57-2.56; P < .001), and Jak inhibitor monotherapy (OR, 1.82; 95% CI, 1.21-2.73; P = .004) but not among those who received a TNF inhibitor in combination with methotrexate therapy (OR, 1.18; 95% CI, 0.85-1.63; P = .33). Similar findings were obtained in analyses that accounted for potential reporting bias and sensitivity analyses that excluded patients with a COVID-19 diagnosis based on symptoms alone.\n\nIn this cohort study, TNF inhibitor monotherapy was associated with a lower risk of adverse COVID-19 outcomes compared with other commonly prescribed immunomodulatory treatment regimens among individuals with IMIDs.", "doi": "10.1001/jamanetworkopen.2021.29639", "pmid": "34661663", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2785080"}], "notes": [], "created": "2021-10-21T05:00:02.951Z", "modified": "2021-10-21T05:00:02.965Z"}, {"entity": "publication", "iuid": "7fc8b99cd85b4160bbeae8e8055a3a47", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7fc8b99cd85b4160bbeae8e8055a3a47.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7fc8b99cd85b4160bbeae8e8055a3a47"}}, "title": "The use of Faecal Microbiota Transplantation (FMT) in Europe: A Europe-wide survey.", "authors": [{"family": "Baunwall", "given": "Simon Mark Dahl", "initials": "SMD"}, {"family": "Terveer", "given": "Elisabeth M", "initials": "EM"}, {"family": "Dahlerup", "given": "Jens Frederik", "initials": "JF"}, {"family": "Erikstrup", "given": "Christian", "initials": "C"}, {"family": "Arkkila", "given": "Perttu", "initials": "P"}, {"family": "Vehreschild", "given": "Maria Jgt", "initials": "MJ"}, {"family": "Ianiro", "given": "Gianluca", "initials": "G"}, {"family": "Gasbarrini", "given": "Antonio", "initials": "A"}, {"family": "Sokol", "given": "Harry", "initials": "H"}, {"family": "Kump", "given": "Patrizia K", "initials": "PK"}, {"family": "Satokari", "given": "Reetta", "initials": "R"}, {"family": "De Looze", "given": "Danny", "initials": "D"}, {"family": "Vermeire", "given": "S\u00e9verine", "initials": "S"}, {"family": "Nakov", "given": "Radislav", "initials": "R"}, {"family": "Brezina", "given": "Jan", "initials": "J"}, {"family": "Helms", "given": "Morten", "initials": "M"}, {"family": "Kjeldsen", "given": "Jens", "initials": "J"}, {"family": "Rode", "given": "Anne A", "initials": "AA"}, {"family": "Kousgaard", "given": "Sabrina Just", "initials": "SJ"}, {"family": "Alric", "given": "Laurent", "initials": "L"}, {"family": "Trang-Poisson", "given": "Caroline", "initials": "C"}, {"family": "Scanzi", "given": "Julien", "initials": "J"}, {"family": "Link", "given": "Alexander", "initials": "A"}, {"family": "Stallmach", "given": "Andreas", "initials": "A"}, {"family": "Kupcinskas", "given": "Juozas", "initials": "J"}, {"family": "Johnsen", "given": "Peter Holger", "initials": "PH"}, {"family": "Garborg", "given": "Kjetil", "initials": "K"}, {"family": "Rodr\u00edguez", "given": "Eugenia S\u00e1nchez", "initials": "ES"}, {"family": "Serrander", "given": "Lena", "initials": "L"}, {"family": "Brummer", "given": "Robert J", "initials": "RJ"}, {"family": "Galp\u00e9rine", "given": "Katerina Tatiana", "initials": "KT"}, {"family": "Goldenberg", "given": "Simon D", "initials": "SD"}, {"family": "Mullish", "given": "Benjamin H", "initials": "BH"}, {"family": "Williams", "given": "Horace Rt", "initials": "HR"}, {"family": "Iqbal", "given": "Tariq H", "initials": "TH"}, {"family": "Ponsioen", "given": "Cyriel", "initials": "C"}, {"family": "Kuijper", "given": "Ed J", "initials": "EJ"}, {"family": "Cammarota", "given": "Giovanni", "initials": "G"}, {"family": "Keller", "given": "Josbert J", "initials": "JJ"}, {"family": "Hvas", "given": "Christian Lodberg", "initials": "CL"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "9", "pages": "100181", "issn-l": null}, "abstract": "Faecal microbiota transplantation (FMT) is an emerging treatment modality, but its current clinical use and organisation are unknown. We aimed to describe the clinical use, conduct, and potential for FMT in Europe.\n\nWe invited all hospital-based FMT centres within the European Council member states to answer a web-based questionnaire covering their clinical activities, organisation, and regulation of FMT in 2019. Responders were identified from trials registered at clinicaltrials.gov and from the United European Gastroenterology (UEG) working group for stool banking and FMT.\n\nIn 2019, 31 FMT centres from 17 countries reported a total of 1,874 (median 25, quartile 10-64) FMT procedures; 1,077 (57%) with Clostridioides difficile infection (CDI) as indication, 791 (42%) with experimental indications, and 6 (0\u20223%) unaccounted for. Adjusted to population size, 0\u2022257 per 100,000 population received FMT for CDI and 0\u2022189 per 100,000 population for experimental indications. With estimated 12,400 (6,100-28,500) annual cases of multiple, recurrent CDI and indication for FMT in Europe, the current European FMT activity covers approximately 10% of the patients with indication. The participating centres demonstrated high safety standards and adherence to international consensus guidelines. Formal or informal regulation from health authorities was present at 21 (68%) centres.\n\nFMT is a widespread routine treatment for multiple, recurrent CDI and an experimental treatment. Embedded within hospital settings, FMT centres operate with high standards across Europe to provide safe FMT. A significant gap in FMT coverage suggests the need to raise clinical awareness and increase the FMT activity in Europe by at least 10-fold to meet the true, indicated need.\n\nNordForsk under the Nordic Council and Innovation Fund Denmark (j.no. 8056-00006B).", "doi": "10.1016/j.lanepe.2021.100181", "pmid": "34693388", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00158-7"}, {"db": "pmc", "key": "PMC8513118"}], "notes": [], "created": "2021-10-26T18:27:35.950Z", "modified": "2021-10-26T18:27:57.245Z"}, {"entity": "publication", "iuid": "5d42e9f095cf48b98731eed07b48a1a8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d42e9f095cf48b98731eed07b48a1a8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d42e9f095cf48b98731eed07b48a1a8"}}, "title": "Spotlight influenza: The 2019/20 influenza season and the impact of COVID-19 on influenza surveillance in the WHO European Region.", "authors": [{"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Sneiderman", "given": "Miriam", "initials": "M"}, {"family": "Martinuka", "given": "Oksana", "initials": "O"}, {"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Fielding", "given": "James", "initials": "J"}, {"family": "Olsen", "given": "Sonja J", "initials": "SJ"}, {"family": "Penttinen", "given": "Pasi", "initials": "P"}, {"family": "Pastore", "given": "Lucia", "initials": "L"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "European Influenza Surveillance Network", "given": "", "initials": ""}, {"family": "Members of the European Influenza Surveillance Network", "given": "", "initials": ""}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "40", "issn-l": null}, "abstract": "BackgroundAnnual seasonal influenza activity in the northern hemisphere causes a high burden of disease during the winter months, peaking in the first weeks of the year.AimWe describe the 2019/20 influenza season and the impact of the COVID-19 pandemic on sentinel surveillance in the World Health Organization (WHO) European Region.MethodsWe analysed weekly epidemiological and virological influenza data from sentinel primary care and hospital sources reported by countries, territories and areas (hereafter countries) in the European Region.ResultsWe observed co-circulation of influenza B/Victoria-lineage, A(H1)pdm09 and A(H3) viruses during the 2019/20 season, with different dominance patterns observed across the Region. A higher proportion of patients with influenza A virus infection than type B were observed. The influenza activity started in week 47/2019, and influenza positivity rate was \u2265 50% for 2 weeks (05-06/2020) rather than 5-8 weeks in the previous five seasons. In many countries a rapid reduction in sentinel reports and the highest influenza activity was observed in weeks 09-13/2020. Reporting was reduced from week 14/2020 across the Region coincident with the onset of widespread circulation of SARS-CoV-2.ConclusionsOverall, influenza type A viruses dominated; however, there were varying patterns across the Region, with dominance of B/Victoria-lineage viruses in a few countries. The COVID-19 pandemic contributed to an earlier end of the influenza season and reduced influenza virus circulation probably owing to restricted healthcare access and public health measures.", "doi": "10.2807/1560-7917.ES.2021.26.40.2100077", "pmid": "34622760", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:06:43.120Z", "modified": "2021-10-10T15:06:43.131Z"}, {"entity": "publication", "iuid": "52cf49fa75ee488785e083c10c6c9168", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/52cf49fa75ee488785e083c10c6c9168.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/52cf49fa75ee488785e083c10c6c9168"}}, "title": "Soluble angiotensin-converting enzyme 2 is transiently elevated in COVID-19 and correlates with specific inflammatory and endothelial markers.", "authors": [{"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A", "orcid": "0000-0003-1671-0827", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44c5053ce647424f8fd0c263dd655572.json"}}, {"family": "Ziegler", "given": "Louise", "initials": "L"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Rudberg", "given": "Ann-Sofie", "initials": "AS"}, {"family": "von Meijenfeldt", "given": "Fien", "initials": "F"}, {"family": "Lisman", "given": "Ton", "initials": "T"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Sand\u00e9n", "given": "Per", "initials": "P"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "J Med Virol", "issn": "1096-9071", "issn-l": null, "volume": "93", "issue": "10", "pages": "5908-5916"}, "abstract": "The main entry receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is angiotensin-converting enzyme 2 (ACE2). SARS-CoV-2 interactions with ACE2 may increase ectodomain shedding but consequences for the renin-angiotensin system and pathology in Coronavirus disease 2019 (COVID-19) remain unclear. We measured soluble ACE2 (sACE2) and sACE levels by enzyme-linked immunosorbent assay in 114 hospital-treated COVID-19 patients compared with 10 healthy controls; follow-up samples after four months were analyzed for 58 patients. Associations between sACE2 respectively sACE and risk factors for severe COVID-19, outcome, and inflammatory markers were investigated. Levels of sACE2 were higher in COVID-19 patients than in healthy controls, median 5.0 (interquartile range 2.8-11.8) ng/ml versus 1.4 (1.1-1.6) ng/ml, p < .0001. sACE2 was higher in men than women but was not affected by other risk factors for severe COVID-19. sACE2 decreased to 2.3 (1.6-3.9) ng/ml at follow-up, p < .0001, but remained higher than in healthy controls, p = .012. sACE was marginally lower during COVID-19 compared with at follow-up, 57 (45-70) ng/ml versus 72 (52-87) ng/ml, p = .008. Levels of sACE2 and sACE did not differ depending on survival or disease severity. sACE2 during COVID-19 correlated with von Willebrand factor, factor VIII and D-dimer, while sACE correlated with interleukin 6, tumor necrosis factor \u03b1, and plasminogen activator inhibitor 1. Conclusions: sACE2 was transiently elevated in COVID-19, likely due to increased shedding from infected cells. sACE2 and sACE during COVID-19 differed in correlations with markers of inflammation and endothelial dysfunction, suggesting release from different cell types and/or vascular beds.", "doi": "10.1002/jmv.27144", "pmid": "34138483", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC8426677"}], "notes": [], "created": "2021-06-28T18:38:59.230Z", "modified": "2021-12-12T18:08:59.955Z"}, {"entity": "publication", "iuid": "01ea523b4e384149a00f4668eae77d0b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01ea523b4e384149a00f4668eae77d0b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01ea523b4e384149a00f4668eae77d0b"}}, "title": "Serum Neurofilament Light is elevated in COVID-19 Positive Adults in the ICU and is associated with Co-Morbid Cardiovascular Disease, Neurological Complications, and Acuity of Illness.", "authors": [{"family": "Hay", "given": "Meredith", "initials": "M"}, {"family": "Ryan", "given": "Lee", "initials": "L"}, {"family": "Huentelman", "given": "Matthew", "initials": "M"}, {"family": "Konhilas", "given": "John", "initials": "J"}, {"family": "Hoyer-Kimura", "given": "Christina", "initials": "C"}, {"family": "Beach", "given": "Thomas G", "initials": "TG"}, {"family": "Serrano", "given": "Geidy E", "initials": "GE"}, {"family": "Reiman", "given": "Eric M", "initials": "EM"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Parthasarathy", "given": "Sairam", "initials": "S"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Cardiol Cardiovasc Med", "issn": "2572-9292", "volume": "5", "issue": "5", "pages": "551-565", "issn-l": null}, "abstract": "In critically ill COVID-19 patients, the risk of long-term neurological consequences is just beginning to be appreciated. While recent studies have identified that there is an increase in structural injury to the nervous system in critically ill COVID-19 patients, there is little known about the relationship of COVID-19 neurological damage to the systemic inflammatory diseases also observed in COVID-19 patients. The purpose of this pilot observational study was to examine the relationships between serum neurofilament light protein (NfL, a measure of neuronal injury) and co-morbid cardiovascular disease (CVD) and neurological complications in COVID-19 positive patients admitted to the intensive care unit (ICU). In this observational study of one-hundred patients who were admitted to the ICU in Tucson, Arizona between April and August 2020, 89 were positive for COVID-19 (COVID-pos) and 11 was COVID-negative (COVID-neg). A healthy control group (n=8) was examined for comparison. The primary outcomes and measures were subject demographics, serum NfL, presence and extent of CVD, diabetes, sequential organ failure assessment score (SOFA), presence of neurological complications, and blood chemistry panel data. COVID-pos patients in the ICU had significantly higher mean levels of Nfl (229.6 \u00b1 163 pg/ml) compared to COVID-neg ICU patients (19.3 \u00b1 5.6 pg/ml), Welch's t-test, p =.01 and healthy controls (12.3 \u00b1 3.1 pg/ml), Welch's t-test p =.005. Levels of Nfl in COVID-pos ICU patients were significantly higher in patients with concomitant CVD and diabetes (n=35, log Nfl 1.6\u00b1.09), and correlated with higher SOFA scores (r=.5, p =.001). These findings suggest that in severe COVID-19 disease, the central neuronal and axonal damage in these patients may be driven, in part, by the level of systemic cardiovascular disease and peripheral inflammation. Understanding the contributions of systemic inflammatory disease to central neurological degeneration in these COVID-19 survivors will be important to the design of interventional therapies to prevent long-term neurological and cognitive dysfunction.", "doi": "10.26502/fccm.92920221", "pmid": "34708189", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "mid", "key": "NIHMS1747952"}, {"db": "pmc", "key": "PMC8547787"}], "notes": [], "created": "2021-11-01T19:47:57.104Z", "modified": "2023-06-19T15:21:50.201Z"}, {"entity": "publication", "iuid": "9946b87cc5bd4651ae99d7288a850d43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9946b87cc5bd4651ae99d7288a850d43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9946b87cc5bd4651ae99d7288a850d43"}}, "title": "Sensing Inflammation Biomarkers with Electrolyte-Gated Organic Electronic Transistors.", "authors": [{"family": "Burtscher", "given": "Bernhard", "initials": "B", "orcid": "0000-0002-6394-2965", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/775b6ad4fdd94a49be50ac83e6fe8a95.json"}}, {"family": "Manco Urbina", "given": "Pamela Allison", "initials": "PA", "orcid": "0000-0002-3687-9374", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28ab31b512ad40de91c56fd73276984b.json"}}, {"family": "Diacci", "given": "Chiara", "initials": "C", "orcid": "0000-0002-2724-5601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa70b059609b44d8bf593f50cd699e52.json"}}, {"family": "Borghi", "given": "Simone", "initials": "S"}, {"family": "Pinti", "given": "Marcello", "initials": "M", "orcid": "0000-0001-9118-1262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10ebafa0cfa8439a8ffac27e8bdd120c.json"}}, {"family": "Cossarizza", "given": "Andrea", "initials": "A", "orcid": "0000-0002-5381-1558", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/916b3aa37d1744669bc10dd62e1cf8e7.json"}}, {"family": "Salvarani", "given": "Carlo", "initials": "C"}, {"family": "Berggren", "given": "Magnus", "initials": "M", "orcid": "0000-0001-5154-0291", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5fe2982d17543c480280343ade44a80.json"}}, {"family": "Biscarini", "given": "Fabio", "initials": "F", "orcid": "0000-0001-6648-5803", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e151476689844559964e691404f10b86.json"}}, {"family": "Simon", "given": "Daniel T", "initials": "DT", "orcid": "0000-0002-2799-3490", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21fd8689ce8c4a2fa58fb71b5118ae8b.json"}}, {"family": "Bortolotti", "given": "Carlo A", "initials": "CA", "orcid": "0000-0002-5701-5727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d460780d1154424e898f79de064fc43d.json"}}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Adv Healthc Mater", "issn": "2192-2659", "issn-l": null, "volume": "10", "issue": "20", "pages": "e2100955"}, "abstract": "An overview of cytokine biosensing is provided, with a focus on the opportunities provided by organic electronic platforms for monitoring these inflammation biomarkers which manifest at ultralow concentration levels in physiopathological conditions. Specifically, two of the field's state-of-the-art technologies-organic electrochemical transistors (OECTs) and electrolyte gated organic field effect transistors (EGOFETs)-and their use in sensing cytokines and other proteins associated with inflammation are a particular focus. The overview will include an introduction to current clinical and \"gold standard\" quantification techniques and their limitations in terms of cost, time, and required infrastructure. A critical review of recent progress with OECT- and EGOFET-based protein biosensors is presented, alongside a discussion onthe future of these technologies in the years and decades ahead. This is especially timely as the world grapples with limited healthcare diagnostics during the Coronavirus disease (COVID-19)pandemic where one of the worst-case scenarios for patients is the \"cytokine storm.\" Clearly, low-cost point-of-care technologies provided by OECTs and EGOFETs can ease the global burden on healthcare systems and support professionals by providing unprecedented wealth of data that can help to monitor disease progression in real time.", "doi": "10.1002/adhm.202100955", "pmid": "34423579", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-08-27T09:41:17.223Z", "modified": "2021-11-18T13:40:51.005Z"}, {"entity": "publication", "iuid": "fe3461dafb2240a49bb2996b40ff380c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fe3461dafb2240a49bb2996b40ff380c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fe3461dafb2240a49bb2996b40ff380c"}}, "title": "Parent-adolescent relationship quality as a moderator of links between COVID-19 disruption and reported changes in mothers' and young adults' adjustment in five countries.", "authors": [{"family": "Skinner", "given": "Ann T", "initials": "AT", "orcid": "0000-0001-8083-9487", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9bffc80b3a4b46789e77b9c9ea4203e6.json"}}, {"family": "Godwin", "given": "Jennifer", "initials": "J", "orcid": "0000-0001-5258-1351", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/abcc5b41ac7f4a7ebfebc17357ea4572.json"}}, {"family": "Alampay", "given": "Liane Pe\u00f1a", "initials": "LP", "orcid": "0000-0002-5760-6711", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39138bdb521f47d48ca20c6fd5097285.json"}}, {"family": "Lansford", "given": "Jennifer E", "initials": "JE", "orcid": "0000-0003-1956-4917", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/099f957450e743acab538878cc487a27.json"}}, {"family": "Bacchini", "given": "Dario", "initials": "D", "orcid": "0000-0001-6140-9377", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/087d86a987214e3e8b685b9dd31e4ccd.json"}}, {"family": "Bornstein", "given": "Marc H", "initials": "MH"}, {"family": "Deater-Deckard", "given": "Kirby", "initials": "K", "orcid": "0000-0003-4151-2152", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/211fa4b8046243e8b96ed9460dccd222.json"}}, {"family": "Di Giunta", "given": "Laura", "initials": "L"}, {"family": "Dodge", "given": "Kenneth A", "initials": "KA", "orcid": "0000-0001-5932-215X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68152786a6394d79b8261287f8020279.json"}}, {"family": "Gurdal", "given": "Sevtap", "initials": "S", "orcid": "0000-0001-7881-5670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3aa5a20191b040fc8d432e7deea46c90.json"}}, {"family": "Pastorelli", "given": "Concetta", "initials": "C", "orcid": "0000-0003-2837-7312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e126c726417442bafb6eb57680a7032.json"}}, {"family": "Sorbring", "given": "Emma", "initials": "E"}, {"family": "Steinberg", "given": "Laurence", "initials": "L"}, {"family": "Tapanya", "given": "Sombat", "initials": "S", "orcid": "0000-0002-2461-6593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eed362b8f81241e1a43f524c3f2b0c3d.json"}}, {"family": "Yotanyamaneewong", "given": "Saengduean", "initials": "S"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Dev Psychol", "issn": "1939-0599", "volume": "57", "issue": "10", "pages": "1648-1666", "issn-l": null}, "abstract": "The COVID-19 pandemic has presented families around the world with extraordinary challenges related to physical and mental health, economic security, social support, and education. The current study capitalizes on a longitudinal, cross-national study of parenting, adolescent development, and young adult competence to document the association between personal disruption during the pandemic and reported changes in internalizing and externalizing behavior in young adults and their mothers since the pandemic began. It further investigates whether family functioning during adolescence 3 years earlier moderates this association. Data from 484 families in five countries (Italy, the Philippines, Sweden, Thailand, and the United States) reveal that higher levels of reported disruption during the pandemic are related to reported increases in internalizing and externalizing behaviors after the onset of the COVID-19 pandemic for young adults (Mage = 20) and their mothers in all five countries, with the exception of one association in Thailand. Associations between disruption during the pandemic and young adults' and their mothers' reported increases in internalizing and externalizing behaviors were attenuated by higher levels of youth disclosure, more supportive parenting, and lower levels of destructive adolescent-parent conflict prior to the pandemic. This work has implications for fostering parent-child relationships characterized by warmth, acceptance, trust, open communication, and constructive conflict resolution at all times given their protective effects for family resilience during times of crisis. (PsycInfo Database Record (c) 2021 APA, all rights reserved).", "doi": "10.1037/dev0001236", "pmid": "34807687", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2022-06056-008"}], "notes": [], "created": "2021-11-26T13:55:20.287Z", "modified": "2021-11-26T13:55:20.643Z"}, {"entity": "publication", "iuid": "ec27250dd69044d38fecd673f5baf25d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec27250dd69044d38fecd673f5baf25d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec27250dd69044d38fecd673f5baf25d"}}, "title": "Organisational Response Strategies to COVID-19 in the Sharing Economy.", "authors": [{"family": "Mont", "given": "Oksana", "initials": "O"}, {"family": "Curtis", "given": "Steven Kane", "initials": "SK"}, {"family": "Voytenko Palgan", "given": "Yuliya", "initials": "Y"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Sustain Prod Consum", "issn": "2352-5509", "volume": "28", "pages": "52-70", "issn-l": null}, "abstract": "The COVID-19 pandemic has impacted production and consumption patterns across the world and forced many organisations to respond. However, there is a lack of understanding as to how sharing platforms have been affected by the pandemic, how they responded to the crisis, and what kinds of long-term implications the pandemic may have on the sharing economy. This study combined systematic literature review and qualitative web analysis of 30 mobility, space, and goods sharing platforms of different business models and geographies. An empirically-driven framework of organisational responses to COVID-19 was developed that comprises eight overarching response strategies targeting the organisation, users, and society. It is a novel framework that structures organisational responses to a high-impact, low-probability crisis. This study also discusses the long-term implications of the COVID-19 pandemic on the sharing economy, and explores how this may impact future responses among sharing platforms in the society that seeks sustainability. The learnings of this study have real-world significance. Sharing platforms can learn from each other about how to continue to respond in the face of the ongoing pandemic, and consider actions for future preparedness to potential forthcoming crises. With this we hope to encourage perseverance, long-term viability, sustainability, and resilience in organisations that may offer more sustainable ways of consumption and production.", "doi": "10.1016/j.spc.2021.03.025", "pmid": "34786447", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2352-5509(21)00098-1"}, {"db": "pmc", "key": "PMC8581630"}], "notes": [], "created": "2021-11-26T14:11:21.267Z", "modified": "2021-11-26T14:11:21.302Z"}, {"entity": "publication", "iuid": "4af14da35f39433b9b62419f6e6082e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4af14da35f39433b9b62419f6e6082e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4af14da35f39433b9b62419f6e6082e2"}}, "title": "Occupational risk of COVID-19 in the first versus second epidemic wave in Norway, 2020.", "authors": [{"family": "Magnusson", "given": "Karin", "initials": "K"}, {"family": "Nyg\u00e5rd", "given": "Karin", "initials": "K"}, {"family": "Methi", "given": "Fredrik", "initials": "F"}, {"family": "Vold", "given": "Line", "initials": "L"}, {"family": "Telle", "given": "Kjetil", "initials": "K"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "40", "issn-l": null}, "abstract": "BackgroundThe occupational risk of COVID-19 may be different in the first versus second epidemic wave.AimTo study whether employees in occupations that typically entail close contact with others were at higher risk of SARS-CoV-2 infection and COVID-19-related hospitalisation during the first and second epidemic wave before and after 18 July 2020, in Norway.MethodsWe included individuals in occupations working with patients, children, students, or customers using Standard Classification of Occupations (ISCO-08) codes. We compared residents (3,559,694 on 1 January 2020) in such occupations aged 20-70 years (mean: 44.1; standard deviation: 14.3 years; 51% men) to age-matched individuals in other professions using logistic regression adjusted for age, sex, birth country and marital status.ResultsNurses, physicians, dentists and physiotherapists had 2-3.5 times the odds of COVID-19 during the first wave when compared with others of working age. In the second wave, bartenders, waiters, food counter attendants, transport conductors, travel stewards, childcare workers, preschool and primary school teachers had ca 1.25-2 times the odds of infection. Bus, tram and taxi drivers had an increased odds of infection in both waves (odds ratio: 1.2-2.1). Occupation was of limited relevance for the odds of severe infection, here studied as hospitalisation with the disease.ConclusionOur findings from the entire Norwegian population may be of relevance to national and regional authorities in handling the epidemic. Also, we provide a knowledge foundation for more targeted future studies of lockdowns and disease control measures.", "doi": "10.2807/1560-7917.ES.2021.26.40.2001875", "pmid": "34622761", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:06:17.118Z", "modified": "2021-10-10T15:06:17.128Z"}, {"entity": "publication", "iuid": "9741f4d2903843baa47aa592053d5733", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9741f4d2903843baa47aa592053d5733.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9741f4d2903843baa47aa592053d5733"}}, "title": "Neurochemical biomarkers to study CNS effects of COVID-19: A narrative review and synthesis.", "authors": [{"family": "Ed\u00e9n", "given": "Arvid", "initials": "A", "orcid": "0000-0003-2817-9981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54411b4f4cbe422697c5eb3080c23e2c.json"}}, {"family": "Simr\u00e9n", "given": "Joel", "initials": "J", "orcid": "0000-0001-5081-6604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00690c8e16a545aea824cdf580837500.json"}}, {"family": "Price", "given": "Richard W", "initials": "RW"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e314740b02c344d2b336a9410e28041e.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "J Neurochem", "issn": "0022-3042", "issn-l": null, "volume": "159", "issue": "1", "pages": "61-77"}, "abstract": "Neurological symptoms are frequently reported in patients suffering from COVID-19. Common CNS-related symptoms include anosmia, caused by viral interaction with either neurons or supporting cells in nasal olfactory tissues. Diffuse encephalopathy is the most common sign of CNS dysfunction, which likely results from the CNS consequences of the systemic inflammatory syndrome associated with severe COVID-19. Additionally, microvascular injuries and thromboembolic events likely contribute to the neurologic impact of acute COVID-19. These observations are supported by evidence of CNS immune activation in cerebrospinal fluid (CSF) and in autopsy tissue, along with the detection of microvascular injuries in both pathological and neuroimaging studies. The frequent occurrence of thromboembolic events in patients with COVID-19 has generated different hypotheses, among which viral interaction with perivascular cells is particularly attractive, yet unproven. A distinguishing feature of CSF findings in SARS-CoV-2 infection is that clinical signs characteristic of neurotropic viral infections (CSF pleocytosis and blood-brain barrier injury) are mild or absent. Moreover, virus detection in CSF is rare and often of uncertain significance. In this review, we provide an overview of the neurological impact that occurs in the acute phase of COVID-19, and the role of CSF biomarkers in the clinical management and research to better treat and understand the disease. In addition to aiding as diagnostic and prognostic tools during acute infection, the use of comprehensive and well-characterized CSF and blood biomarkers will be vital in understanding the potential impact on the CNS in the rapidly increasing number of individuals recovering from COVID-19.", "doi": "10.1111/jnc.15459", "pmid": "34170549", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8420435"}], "notes": [], "created": "2021-06-28T18:12:28.285Z", "modified": "2023-06-19T14:46:17.609Z"}, {"entity": "publication", "iuid": "50547a0d81b74ad4b26b3bcc59ab4b29", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50547a0d81b74ad4b26b3bcc59ab4b29.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50547a0d81b74ad4b26b3bcc59ab4b29"}}, "title": "Increase in invasive disease caused by Haemophilus influenzae b, the Netherlands, 2020 to 2021.", "authors": [{"family": "Steens", "given": "Anneke", "initials": "A"}, {"family": "Stanoeva", "given": "Kamelia R", "initials": "KR"}, {"family": "Knol", "given": "Mirjam J", "initials": "MJ"}, {"family": "Mariman", "given": "Rob", "initials": "R"}, {"family": "de Melker", "given": "Hester E", "initials": "HE"}, {"family": "van Sorge", "given": "Nina M", "initials": "NM"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "42", "issn-l": null}, "abstract": "The incidence of most respiratory-transmitted diseases decreased during the COVID-19 pandemic as a result of containment measures. In contrast, in the Netherlands we noted an increase in invasive disease caused by Haemophilus influenzae b (Hib) (from < 0.3/100,000 before 2019 to 0.39 and 0.33/100,000 in 2020 and 2021) in vaccinated and unvaccinated age groups. We did not find a change in vaccine effectiveness against Hib invasive disease (effectiveness > 90%). We discuss factors that may have contributed to this rise.", "doi": "10.2807/1560-7917.ES.2021.26.42.2100956", "pmid": "34676819", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:12:02.433Z", "modified": "2021-10-26T18:12:02.449Z"}, {"entity": "publication", "iuid": "264e8f754e3946e2989b2a9c23cbe27b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/264e8f754e3946e2989b2a9c23cbe27b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/264e8f754e3946e2989b2a9c23cbe27b"}}, "title": "HMG-CoA reductase inhibitors and COVID-19 mortality in Stockholm, Sweden: A registry-based cohort study.", "authors": [{"family": "Bergqvist", "given": "Rita", "initials": "R"}, {"family": "Ahlqvist", "given": "Viktor H", "initials": "VH", "orcid": "0000-0003-1383-3194", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90ca532443fd48bf801018fc17345726.json"}}, {"family": "Lundberg", "given": "Michael", "initials": "M"}, {"family": "Hergens", "given": "Maria-Pia", "initials": "MP", "orcid": "0000-0001-5397-3541", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11f60a8ed4e849fab81602d86dce5819.json"}}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2c4588f000c470abf08f2e40852b6d1.json"}}, {"family": "Bell", "given": "Max", "initials": "M", "orcid": "0000-0001-7464-0324", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/530f7609a1f143b69691db5c41b14412.json"}}, {"family": "Magnusson", "given": "Cecilia", "initials": "C"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "PLoS Med", "issn": "1549-1676", "volume": "18", "issue": "10", "pages": "e1003820", "issn-l": "1549-1277"}, "abstract": "The relationship between statin treatment and Coronavirus Disease 2019 (COVID-19) mortality has been discussed due to the pleiotropic effects of statins on coagulation and immune mechanisms. However, available observational studies are hampered by study design flaws, resulting in substantial heterogeneity and ambiguities. Here, we aim to determine the relationship between statin treatment and COVID-19 mortality.\n\nThis cohort study included all Stockholm residents aged 45 or older (N = 963,876), followed up from 1 March 2020 until 11 November 2020. The exposure was statin treatment initiated before the COVID-19-pandemic, defined as recorded statin dispensation in the Swedish Prescribed Drug Register between 1 March 2019 and 29 February 2020. COVID-19-specific mortality was ascertained from the Swedish Cause of Death Registry. Hazard ratios (HRs) were calculated using multivariable Cox regression models. We further performed a target trial emulation restricted to initiators of statins. In the cohort (51.6% female), 169,642 individuals (17.6%) were statin users. Statin users were older (71.0 versus 58.0 years), more likely to be male (53.3% versus 46.7%), more often diagnosed with comorbidities (for example, ischemic heart disease 23.3% versus 1.6%), more frequently on anticoagulant and antihypertensive treatments, less likely to have a university-level education (34.5% versus 45.4%), and more likely to have a low disposable income (20.6% versus 25.2%), but less likely to reside in crowded housing (6.1% versus 10.3%). A total of 2,545 individuals died from COVID-19 during follow-up, including 765 (0.5%) of the statin users and 1,780 (0.2%) of the nonusers. Statin treatment was associated with a lowered COVID-19 mortality (adjusted HR, 0.88; 95% CI, 0.79 to 0.97, P = 0.01), and this association did not vary appreciably across age groups, sexes, or COVID-19 risk groups. The confounder adjusted HR for statin treatment initiators was 0.78 (95% CI, 0.59 to 1.05, P = 0.10) in the emulated target trial. Limitations of this study include the observational design, reliance on dispensation data, and the inability to study specific drug regimens.\n\nStatin treatment had a modest negative association with COVID-19 mortality. While this finding needs confirmation from randomized clinical trials, it supports the continued use of statin treatment for medical prevention according to current recommendations also during the COVID-19 pandemic.", "doi": "10.1371/journal.pmed.1003820", "pmid": "34648516", "labels": {"Category: Health": null, "Type: Journal article": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC8516243"}, {"db": "pii", "key": "PMEDICINE-D-21-02232"}], "notes": [], "created": "2021-10-21T05:06:28.806Z", "modified": "2023-01-13T14:42:42.766Z"}, {"entity": "publication", "iuid": "070a956c8f97485fbf74e03ed65eb838", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/070a956c8f97485fbf74e03ed65eb838.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/070a956c8f97485fbf74e03ed65eb838"}}, "title": "Factors for severe outcomes following SARS-CoV-2 infection in people with cystic fibrosis in Europe.", "authors": [{"family": "Jung", "given": "Andreas", "initials": "A", "orcid": "0000-0002-3505-6691", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00c3b50ae199470f9bbc3b6bab2a599d.json"}}, {"family": "Orenti", "given": "Annalisa", "initials": "A", "orcid": "0000-0002-0932-2757", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/962bc29291b04906a8412549987b427c.json"}}, {"family": "Dunlevy", "given": "Fiona", "initials": "F"}, {"family": "Aleksejeva", "given": "Elina", "initials": "E"}, {"family": "Bakkeheim", "given": "Egil", "initials": "E"}, {"family": "Bobrovnichy", "given": "Vladimir", "initials": "V"}, {"family": "Carr", "given": "Siobh\u00e1n B", "initials": "SB", "orcid": "0000-0003-0580-2478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37c62afad5b0418795bcc11860e944d5.json"}}, {"family": "Colombo", "given": "Carla", "initials": "C"}, {"family": "Corvol", "given": "Harriet", "initials": "H", "orcid": "0000-0002-7026-7523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3dc3bf5305094e88997c92b54ffda9b8.json"}}, {"family": "Cosgriff", "given": "Rebecca", "initials": "R"}, {"family": "Daneau", "given": "G\u00e9raldine", "initials": "G", "orcid": "0000-0002-2570-0893", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/352fa7a9aff1450691a070874ce7939a.json"}}, {"family": "Dogru", "given": "Deniz", "initials": "D", "orcid": "0000-0001-9931-9473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf97852882d74bd98670c8b89f743baa.json"}}, {"family": "Drevinek", "given": "Pavel", "initials": "P"}, {"family": "Vukic", "given": "Andrea Dugac", "initials": "AD"}, {"family": "Fajac", "given": "Isabelle", "initials": "I"}, {"family": "Fox", "given": "Alice", "initials": "A"}, {"family": "Fustik", "given": "Stojka", "initials": "S"}, {"family": "Gulmans", "given": "Vincent", "initials": "V"}, {"family": "Harutyunyan", "given": "Satenik", "initials": "S"}, {"family": "Hatziagorou", "given": "Elpis", "initials": "E"}, {"family": "Kasmi", "given": "Irena", "initials": "I"}, {"family": "Kayserov\u00e1", "given": "Hana", "initials": "H"}, {"family": "Kondratyeva", "given": "Elena", "initials": "E"}, {"family": "Krivec", "given": "Uro\u0161", "initials": "U", "orcid": "0000-0001-9031-5708", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c56e1173942d414f9bee9e0b7006273e.json"}}, {"family": "Makukh", "given": "Halyna", "initials": "H"}, {"family": "Malakauskas", "given": "Kestutis", "initials": "K"}, {"family": "McKone", "given": "Edward F", "initials": "EF"}, {"family": "Mei-Zahav", "given": "Meir", "initials": "M"}, {"family": "de Monestrol", "given": "Isabelle", "initials": "I"}, {"family": "Olesen", "given": "Hanne Vebert", "initials": "HV"}, {"family": "Padoan", "given": "Rita", "initials": "R"}, {"family": "Parulava", "given": "Tsitsino", "initials": "T", "orcid": "0000-0003-2467-7940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ef1c5c5029f47588fb30cbf14f2c597.json"}}, {"family": "Pastor-Vivero", "given": "Maria Dolores", "initials": "MD", "orcid": "0000-0001-8917-4709", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9014de29de4dab95548371cdc7e217.json"}}, {"family": "Pereira", "given": "Lu\u00edsa", "initials": "L"}, {"family": "Petrova", "given": "Guergana", "initials": "G"}, {"family": "Pfleger", "given": "Andreas", "initials": "A"}, {"family": "Pop", "given": "Liviu", "initials": "L"}, {"family": "van Rens", "given": "Jacqui G", "initials": "JG"}, {"family": "Rodic", "given": "Milan", "initials": "M"}, {"family": "Schlesser", "given": "Marc", "initials": "M"}, {"family": "Storms", "given": "Val\u00e9rie", "initials": "V", "orcid": "0000-0001-9344-0248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8126464b476e4745b3b2120dac24b72f.json"}}, {"family": "Turcu", "given": "Oxana", "initials": "O"}, {"family": "Woz Niacki", "given": "Lukasz", "initials": "L"}, {"family": "Yiallouros", "given": "Panayiotis", "initials": "P"}, {"family": "Zolin", "given": "Anna", "initials": "A"}, {"family": "Downey", "given": "Damian G", "initials": "DG"}, {"family": "Naehrlich", "given": "Lutz", "initials": "L"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "ERJ Open Res", "issn": "2312-0541", "volume": "7", "issue": "4", "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in people with cystic fibrosis (pwCF) can lead to severe outcomes.\n\nIn this observational study, the European Cystic Fibrosis Society Patient Registry collected data on pwCF and SARS-CoV-2 infection to estimate incidence, describe clinical presentation and investigate factors associated with severe outcomes using multivariable analysis.\n\nUp to December 31, 2020, 26 countries reported information on 828 pwCF and SARS-CoV-2 infection. Incidence was 17.2 per 1000 pwCF (95% CI: 16.0-18.4). Median age was 24 years, 48.4% were male and 9.4% had lung transplants. SARS-CoV-2 incidence was higher in lung-transplanted (28.6; 95% CI: 22.7-35.5) versus non-lung-transplanted pwCF (16.6; 95% CI: 15.4-17.8) (p\u22640.001).SARS-CoV-2 infection caused symptomatic illness in 75.7%. Factors associated with symptomatic SARS-CoV-2 infection were age >40 years, at least one F508del mutation and pancreatic insufficiency.Overall, 23.7% of pwCF were admitted to hospital, 2.5% of those to intensive care, and regretfully 11 (1.4%) died. Hospitalisation, oxygen therapy, intensive care, respiratory support and death were 2- to 6-fold more frequent in lung-transplanted versus non-lung-transplanted pwCF.Factors associated with hospitalisation and oxygen therapy were lung transplantation, cystic fibrosis-related diabetes (CFRD), moderate or severe lung disease and azithromycin use (often considered a surrogate marker for Pseudomonas aeruginosa infection and poorer lung function).\n\nSARS-CoV-2 infection yielded high morbidity and hospitalisation in pwCF. PwCF with forced expiratory volume in 1 s <70% predicted, CFRD and those with lung transplants are at particular risk of more severe outcomes.", "doi": "10.1183/23120541.00411-2021", "pmid": "34984210", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00411-2021"}, {"db": "pmc", "key": "PMC8557394"}], "notes": [], "created": "2022-01-10T15:34:09.247Z", "modified": "2022-01-10T15:34:09.603Z"}, {"entity": "publication", "iuid": "23e85d99f304475997ae98f01d623822", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23e85d99f304475997ae98f01d623822.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23e85d99f304475997ae98f01d623822"}}, "title": "Envisioning a resilient future for biodiversity conservation in the wake of the COVID-19 pandemic.", "authors": [{"family": "Thurstan", "given": "Ruth H", "initials": "RH", "orcid": "0000-0002-8045-1631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fcb1b48a6fa348d1b0a06f61557d25c2.json"}}, {"family": "Hockings", "given": "Kimberley J", "initials": "KJ", "orcid": "0000-0002-6187-644X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e6488f4e007a4830a82eb835a00e807d.json"}}, {"family": "Hedlund", "given": "Johanna S U", "initials": "JSU", "orcid": "0000-0001-5826-9588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8ef2989b3e746898de804b994d7dce5.json"}}, {"family": "Bersacola", "given": "Elena", "initials": "E", "orcid": "0000-0003-3814-8687", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2043264a8a3433e8b7bca33dee4382d.json"}}, {"family": "Collins", "given": "Claire", "initials": "C", "orcid": "0000-0001-8651-7219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d94fde481994e4f8d0214e4b3a08f76.json"}}, {"family": "Early", "given": "Regan", "initials": "R", "orcid": "0000-0003-4108-5904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6de473963b89421bb2904cc6345af2b7.json"}}, {"family": "Ermiasi", "given": "Yunsiska", "initials": "Y"}, {"family": "Fleischer-Dogley", "given": "Frauke", "initials": "F"}, {"family": "Gilkes", "given": "Gabriella", "initials": "G"}, {"family": "Harrison", "given": "Mark E", "initials": "ME", "orcid": "0000-0002-0729-8407", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc453216906d43b4b6139edf47a8ce95.json"}}, {"family": "Imron", "given": "Muhammad Ali", "initials": "MA", "orcid": "0000-0003-2371-7795", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e3434f5422842ffbb00a3cc22eb6f46.json"}}, {"family": "Kaiser-Bunbury", "given": "Christopher N", "initials": "CN", "orcid": "0000-0001-7254-3491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02a818e22a9440dea2df7ffd2a0732c6.json"}}, {"family": "Refly Katoppo", "given": "Daniel", "initials": "D"}, {"family": "Marriott", "given": "Cheryl", "initials": "C"}, {"family": "Muzungaile", "given": "Marie-May", "initials": "M"}, {"family": "Nuno", "given": "Ana", "initials": "A", "orcid": "0000-0003-4680-2378", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f710f96931dc49cda3b9949632fc6a7a.json"}}, {"family": "Regalla de Barros", "given": "Aissa", "initials": "A"}, {"family": "van Veen", "given": "Frank", "initials": "F", "orcid": "0000-0003-0708-5492", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/372d44cb6cf541228033a0d8ae879bf7.json"}}, {"family": "Wijesundara", "given": "Isuru", "initials": "I", "orcid": "0000-0001-8200-458X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52efefa366fc403fb63908c962e9e373.json"}}, {"family": "Dogley", "given": "Didier", "initials": "D"}, {"family": "Bunbury", "given": "Nancy", "initials": "N", "orcid": "0000-0002-5836-5497", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7427d5c15b5c44ef807df90170dca752.json"}}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "People Nat (Hoboken)", "issn": "2575-8314", "issn-l": null, "volume": "3", "issue": "5", "pages": "990-1013"}, "abstract": "As the COVID-19 pandemic continues to affect societies across the world, the ongoing economic and social disruptions are likely to present fundamental challenges for current and future biodiversity conservation.We review the literature for outcomes of past major societal, political, economic and zoonotic perturbations on biodiversity conservation, and demonstrate the complex implications of perturbation events upon conservation efforts. Building on the review findings, we use six in-depth case studies and the emerging literature to identify positive and negative outcomes of the COVID-19 pandemic, known and anticipated, for biodiversity conservation efforts around the world.A number of similarities exist between the current pandemic and past perturbations, with experiences highlighting that the pandemic-induced declines in conservation revenue and capacity, livelihood and trade disruptions are likely to have long-lasting and negative implications for biodiversity and conservation efforts.Yet, the COVID-19 pandemic also brought about a global pause in human movement that is unique in recent history, and may yet foster long-lasting behavioural and societal changes, presenting opportunities to strengthen and advance conservation efforts in the wake of the pandemic. Enhanced collaborations and partnerships at the local level, cross-sectoral engagement, local investment and leadership will all enhance the resilience of conservation efforts in the face of future perturbations. Other actions aimed at enhancing resilience will require fundamental institutional change and extensive government and public engagement and support if they are to be realised.The pandemic has highlighted the inherent vulnerabilities in the social and economic models upon which many conservation efforts are based. In so doing, it presents an opportunity to reconsider the status quo for conservation, and promotes behaviours and actions that are resilient to future perturbation. A free Plain Language Summary can be found within the Supporting Information of this article.", "doi": "10.1002/pan3.10262", "pmid": "34909607", "labels": {"Type: Review": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PAN310262"}, {"db": "pmc", "key": "PMC8661774"}], "notes": [], "created": "2021-12-18T17:50:19.313Z", "modified": "2022-02-17T10:13:54.308Z"}, {"entity": "publication", "iuid": "f4b78ade978c41bf8c14690408b3b554", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f4b78ade978c41bf8c14690408b3b554.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f4b78ade978c41bf8c14690408b3b554"}}, "title": "Diabetes, hypertension, body mass index, smoking and COVID-19-related mortality: a systematic review and meta-analysis of observational studies", "authors": [{"family": "Mahamat-Saleh", "given": "Yahya", "initials": "Y", "orcid": "0000-0002-5892-8886", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9ac3af0c6f044d1b10c29683467d030.json"}}, {"family": "Fiolet", "given": "Thibault", "initials": "T"}, {"family": "Rebeaud", "given": "Mathieu Edouard", "initials": "ME"}, {"family": "Mulot", "given": "Matthieu", "initials": "M"}, {"family": "Guihur", "given": "Anthony", "initials": "A", "orcid": "0000-0001-5353-1428", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9949ce6f1c3744e1b127ab415b2a7470.json"}}, {"family": "El Fatouhi", "given": "Douae", "initials": "D"}, {"family": "Laouali", "given": "Nasser", "initials": "N"}, {"family": "Peiffer-Smadja", "given": "Nathan", "initials": "N"}, {"family": "Aune", "given": "Dagfinn", "initials": "D", "orcid": "0000-0002-4533-1722", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3d9e8a2005a4e6fa5fe266389bf80c0.json"}}, {"family": "Severi", "given": "Gianluca", "initials": "G"}], "type": "journal-article", "published": "2021-10-00", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "10", "pages": "e052777"}, "abstract": null, "doi": "10.1136/bmjopen-2021-052777", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:33:43.138Z", "modified": "2022-02-17T09:57:52.122Z"}, {"entity": "publication", "iuid": "84bae0b622bf41e7ab85af7ea3fd45a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84bae0b622bf41e7ab85af7ea3fd45a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84bae0b622bf41e7ab85af7ea3fd45a4"}}, "title": "Cross-sectional examination of 24-hour movement behaviours among 3- and 4-year-old children in urban and rural settings in low-income, middle-income and high-income countries: the SUNRISE study protocol", "authors": [{"family": "Okely", "given": "Tony", "initials": "T"}, {"family": "Reilly", "given": "John J", "initials": "JJ"}, {"family": "Tremblay", "given": "Mark S", "initials": "MS"}, {"family": "Kariippanon", "given": "Katharina E", "initials": "KE", "orcid": "0000-0003-4269-682X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cdb4f12289b34e8593ad5727870ef08c.json"}}, {"family": "Draper", "given": "Catherine E", "initials": "CE"}, {"family": "El Hamdouchi", "given": "Asmaa", "initials": "A"}, {"family": "Florindo", "given": "Alex A", "initials": "AA"}, {"family": "Green", "given": "Janette P", "initials": "JP"}, {"family": "Guan", "given": "Hongyan", "initials": "H"}, {"family": "Katzmarzyk", "given": "Peter T", "initials": "PT"}, {"family": "Lubree", "given": "Himangi", "initials": "H"}, {"family": "Pham", "given": "Bang Nguyen", "initials": "BN"}, {"family": "Suesse", "given": "Thomas", "initials": "T"}, {"family": "Willumsen", "given": "Juana", "initials": "J"}, {"family": "Basheer", "given": "Mohamed", "initials": "M"}, {"family": "Calleia", "given": "Rebecca", "initials": "R"}, {"family": "Chong", "given": "Kar Hau", "initials": "KH"}, {"family": "Cross", "given": "Penny L", "initials": "PL"}, {"family": "Nacher", "given": "Maria", "initials": "M"}, {"family": "Smeets", "given": "Laura", "initials": "L"}, {"family": "Taylor", "given": "Ellie", "initials": "E"}, {"family": "Abdeta", "given": "Chalchisa", "initials": "C"}, {"family": "Aguilar-Farias", "given": "Nicolas", "initials": "N"}, {"family": "Baig", "given": "Aqsa", "initials": "A"}, {"family": "Bayasgalan", "given": "Jambaldori", "initials": "J"}, {"family": "Chan", "given": "Cecilia H S", "initials": "CHS"}, {"family": "Chathurangana", "given": "P W Prasad", "initials": "PWP"}, {"family": "Chia", "given": "Michael", "initials": "M"}, {"family": "Ghofranipour", "given": "Fazlollah", "initials": "F"}, {"family": "Ha", "given": "Amy S", "initials": "AS"}, {"family": "Hossain", "given": "Mohammad Sorowar", "initials": "MS"}, {"family": "Janssen", "given": "Xanne", "initials": "X"}, {"family": "J\u00e1uregui", "given": "Alejandra", "initials": "A"}, {"family": "Katewongsa", "given": "Piyawat", "initials": "P"}, {"family": "Kim", "given": "Dong Hoon", "initials": "DH"}, {"family": "Kim", "given": "Thanh Van", "initials": "TV"}, {"family": "Koh", "given": "Denise", "initials": "D"}, {"family": "Kontsevaya", "given": "Anna", "initials": "A", "orcid": "0000-0003-2062-1536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c23c67bbbc043aea62ee98370a94ba8.json"}}, {"family": "Leyna", "given": "Germana H", "initials": "GH"}, {"family": "L\u00f6f", "given": "M", "initials": "M"}, {"family": "Munambah", "given": "Nyaradzai", "initials": "N"}, {"family": "Mwase-Vuma", "given": "Tawonga", "initials": "T"}, {"family": "Nusurupia", "given": "Jackline", "initials": "J"}, {"family": "Oluwayomi", "given": "Aoko", "initials": "A"}, {"family": "del Pozo-Cruz", "given": "Borja", "initials": "B"}, {"family": "del Pozo-Cruz", "given": "Jesus", "initials": "J"}, {"family": "Roos", "given": "Eva", "initials": "E"}, {"family": "Shirazi", "given": "Asima", "initials": "A"}, {"family": "Singh", "given": "Pragya", "initials": "P"}, {"family": "Staiano", "given": "Amanda", "initials": "A"}, {"family": "Suherman", "given": "Adang", "initials": "A"}, {"family": "Tanaka", "given": "Chiaki", "initials": "C"}, {"family": "Tang", "given": "Hong Kim", "initials": "HK"}, {"family": "Teo", "given": "Wei Peng", "initials": "WP"}, {"family": "Tiongco", "given": "Marites M", "initials": "MM"}, {"family": "Tladi", "given": "Dawn", "initials": "D"}, {"family": "Turab", "given": "Ali", "initials": "A"}, {"family": "Veldman", "given": "Sanne L C", "initials": "SLC"}, {"family": "Webster", "given": "E Kipling", "initials": "EK"}, {"family": "Wickramasinghe", "given": "Pujitha", "initials": "P"}, {"family": "Widyastari", "given": "Dyah Anantalia", "initials": "DA"}], "type": "journal-article", "published": "2021-10-00", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "10", "pages": "e049267"}, "abstract": null, "doi": "10.1136/bmjopen-2021-049267", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:33:09.365Z", "modified": "2022-02-17T09:46:28.556Z"}, {"entity": "publication", "iuid": "7e8ac1a37684451792822dcb03dc7c4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e8ac1a37684451792822dcb03dc7c4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e8ac1a37684451792822dcb03dc7c4c"}}, "title": "Characteristics and Outcomes of Over 300,000 Patients with COVID-19 and History of Cancer in the United States and Spain.", "authors": [{"family": "Roel", "given": "Elena", "initials": "E", "orcid": "0000-0002-1964-3546", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad1d9cc65d3242339540f938eeceafe1.json"}}, {"family": "Pistillo", "given": "Andrea", "initials": "A", "orcid": "0000-0002-4467-0220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/055156368b8845a0bfdc522a53cc1b0d.json"}}, {"family": "Recalde", "given": "Martina", "initials": "M", "orcid": "0000-0003-2256-618X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a41e082476aa464484b65418923ad81e.json"}}, {"family": "Sena", "given": "Anthony G", "initials": "AG", "orcid": "0000-0001-8630-5347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9202e069d9c24646b006b6abb640b541.json"}}, {"family": "Fern\u00e1ndez-Bertol\u00edn", "given": "Sergio", "initials": "S"}, {"family": "Arag\u00f3n", "given": "Maria", "initials": "M"}, {"family": "Puente", "given": "Diana", "initials": "D"}, {"family": "Ahmed", "given": "Waheed-Ul-Rahman", "initials": "WU", "orcid": "0000-0003-0880-0355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27d074e0c92342d299e693d12173356c.json"}}, {"family": "Alghoul", "given": "Heba", "initials": "H", "orcid": "0000-0001-8234-5843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e3deb1abdf54088a29dee7675a18697.json"}}, {"family": "Alser", "given": "Osaid", "initials": "O", "orcid": "0000-0001-6743-803X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c919eb8e21f74327b80f25eae0313eb6.json"}}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM", "orcid": "0000-0002-5630-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5162aab03bc04dafa809108461f18667.json"}}, {"family": "Areia", "given": "Carlos", "initials": "C", "orcid": "0000-0002-4668-7069", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7232f54be5df43f0b984d0117d88a054.json"}}, {"family": "Blacketer", "given": "Clair", "initials": "C", "orcid": "0000-0003-2570-2124", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a325a8031ace41ed905c1c64b22fc653.json"}}, {"family": "Carter", "given": "William", "initials": "W"}, {"family": "Casajust", "given": "Paula", "initials": "P", "orcid": "0000-0003-2733-5436", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8a3feb959bd461c8c4ad81fcd9dee8b.json"}}, {"family": "Culhane", "given": "Aedin C", "initials": "AC", "orcid": "0000-0002-1395-9734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11a2209eca25401e9870f7b75f66df67.json"}}, {"family": "Dawoud", "given": "Dalia", "initials": "D", "orcid": "0000-0002-2105-1937", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e25c9903cd364cd5a14a32554f63c9da.json"}}, {"family": "DeFalco", "given": "Frank", "initials": "F"}, {"family": "DuVall", "given": "Scott L", "initials": "SL", "orcid": "0000-0002-4898-3865", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd524264c46548cf861123d43d57151a.json"}}, {"family": "Falconer", "given": "Thomas", "initials": "T"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Gong", "given": "Mengchun", "initials": "M"}, {"family": "Hester", "given": "Laura", "initials": "L", "orcid": "0000-0002-4593-1293", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a77277f84d5e433b849001f3287ee330.json"}}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Tan", "given": "Eng Hooi", "initials": "EH", "orcid": "0000-0003-4470-2736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72566a67becb42cab02d274915d24737.json"}}, {"family": "Jeon", "given": "Hokyun", "initials": "H"}, {"family": "Jonnagaddala", "given": "Jitendra", "initials": "J", "orcid": "0000-0002-9912-2344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8403290b9ec43fe93b558de97d84559.json"}}, {"family": "Lai", "given": "Lana Y H", "initials": "LYH", "orcid": "0000-0002-0485-0956", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc15faacca7f4857b5c7babef24ffaf4.json"}}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Natarajan", "given": "Karthik", "initials": "K"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Ostropolets", "given": "Anna", "initials": "A", "orcid": "0000-0002-0847-6682", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f642e577d2445a3a7ce873b42d0c479.json"}}, {"family": "Posada", "given": "Jos\u00e9 D", "initials": "JD"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A", "orcid": "0000-0003-1202-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47f086bb6ccd49a2a5f11a32c06277c8.json"}}, {"family": "Reich", "given": "Christian G", "initials": "CG"}, {"family": "Rivera", "given": "Donna R", "initials": "DR", "orcid": "0000-0002-4565-4556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40627463ecc34b9896787a9a71e3dbad.json"}}, {"family": "Schilling", "given": "Lisa M", "initials": "LM", "orcid": "0000-0002-6878-189X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7888233862b04fce978bb44ece6ccb19.json"}}, {"family": "Soerjomataram", "given": "Isabelle", "initials": "I"}, {"family": "Shah", "given": "Karishma", "initials": "K", "orcid": "0000-0002-6219-1653", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d792a1c7704b4093a3835642181f0865.json"}}, {"family": "Shah", "given": "Nigam H", "initials": "NH", "orcid": "0000-0001-9385-7158", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4aca07eb2cd948c3b736c30cb3f3b6e6.json"}}, {"family": "Shen", "given": "Yang", "initials": "Y"}, {"family": "Spotniz", "given": "Matthew", "initials": "M"}, {"family": "Subbian", "given": "Vignesh", "initials": "V"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Trama", "given": "Annalisa", "initials": "A", "orcid": "0000-0001-8220-9833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b54a2d0430e4ab783fcc82d8c9f8786.json"}}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhang", "given": "Ying", "initials": "Y"}, {"family": "Ryan", "given": "Patrick B", "initials": "PB"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Kostka", "given": "Kristin", "initials": "K", "orcid": "0000-0003-2595-8736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9675cf1b775341f6a3521c7dde950262.json"}}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T", "orcid": "0000-0002-8274-0357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11fd8deb257445e7a93a0a3098b246df.json"}}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Cancer Epidemiol Biomarkers Prev", "issn": "1538-7755", "volume": "30", "issue": "10", "pages": "1884-1894", "issn-l": null}, "abstract": "We described the demographics, cancer subtypes, comorbidities, and outcomes of patients with a history of cancer and coronavirus disease 2019 (COVID-19). Second, we compared patients hospitalized with COVID-19 to patients diagnosed with COVID-19 and patients hospitalized with influenza.\n\nWe conducted a cohort study using eight routinely collected health care databases from Spain and the United States, standardized to the Observational Medical Outcome Partnership common data model. Three cohorts of patients with a history of cancer were included: (i) diagnosed with COVID-19, (ii) hospitalized with COVID-19, and (iii) hospitalized with influenza in 2017 to 2018. Patients were followed from index date to 30 days or death. We reported demographics, cancer subtypes, comorbidities, and 30-day outcomes.\n\nWe included 366,050 and 119,597 patients diagnosed and hospitalized with COVID-19, respectively. Prostate and breast cancers were the most frequent cancers (range: 5%-18% and 1%-14% in the diagnosed cohort, respectively). Hematologic malignancies were also frequent, with non-Hodgkin's lymphoma being among the five most common cancer subtypes in the diagnosed cohort. Overall, patients were aged above 65 years and had multiple comorbidities. Occurrence of death ranged from 2% to 14% and from 6% to 26% in the diagnosed and hospitalized COVID-19 cohorts, respectively. Patients hospitalized with influenza (n = 67,743) had a similar distribution of cancer subtypes, sex, age, and comorbidities but lower occurrence of adverse events.\n\nPatients with a history of cancer and COVID-19 had multiple comorbidities and a high occurrence of COVID-19-related events. Hematologic malignancies were frequent.\n\nThis study provides epidemiologic characteristics that can inform clinical care and etiologic studies.", "doi": "10.1158/1055-9965.EPI-21-0266", "pmid": "34272262", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8974356"}, {"db": "pii", "key": "1055-9965.EPI-21-0266"}], "notes": [], "created": "2023-01-13T09:52:18.710Z", "modified": "2023-06-19T15:34:44.126Z"}, {"entity": "publication", "iuid": "a8edb57968704d61b7823bc613afbe4e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8edb57968704d61b7823bc613afbe4e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8edb57968704d61b7823bc613afbe4e"}}, "title": "COVID19 Disease Map, a computational knowledge repository of virus-host interaction mechanisms.", "authors": [{"family": "Ostaszewski", "given": "Marek", "initials": "M", "orcid": "0000-0003-1473-370X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad3ed3c26f8a4e49aa8edb0bba8ecb19.json"}}, {"family": "Niarakis", "given": "Anna", "initials": "A", "orcid": "0000-0002-9687-7426", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b96190acb1dd484a83a74afc41fd3c8c.json"}}, {"family": "Mazein", "given": "Alexander", "initials": "A", "orcid": "0000-0001-7137-4171", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2efd5e320ebf44e3a1b8847088b7eae7.json"}}, {"family": "Kuperstein", "given": "Inna", "initials": "I", "orcid": "0000-0001-8086-8915", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/43f6315d46434416b8183e06a91084f3.json"}}, {"family": "Phair", "given": "Robert", "initials": "R", "orcid": "0000-0001-7979-2386", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44c205f1ef1a496b8dbdce7fd42c15c0.json"}}, {"family": "Orta-Resendiz", "given": "Aurelio", "initials": "A", "orcid": "0000-0002-6632-883X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53d9ab13209746ada1c3ca163c6c4807.json"}}, {"family": "Singh", "given": "Vidisha", "initials": "V", "orcid": "0000-0002-3250-6669", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/289debcdb0ee477a8c5ea140bb982742.json"}}, {"family": "Aghamiri", "given": "Sara Sadat", "initials": "SS", "orcid": "0000-0003-4440-7059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a27c186dd609468cbe5fdaf53453c8ae.json"}}, {"family": "Acencio", "given": "Marcio Luis", "initials": "ML", "orcid": "0000-0002-8278-240X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7a8ea6189a64d088e7303ec2362fc53.json"}}, {"family": "Glaab", "given": "Enrico", "initials": "E", "orcid": "0000-0003-3977-7469", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ac2ddf4b2f24e89bc6181099aeaf422.json"}}, {"family": "Ruepp", "given": "Andreas", "initials": "A", "orcid": "0000-0003-1705-3515", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc9fc4ee13f04a3ead276fa82d4b6de3.json"}}, {"family": "Fobo", "given": "Gisela", "initials": "G"}, {"family": "Montrone", "given": "Corinna", "initials": "C"}, {"family": "Brauner", "given": "Barbara", "initials": "B"}, {"family": "Frishman", "given": "Goar", "initials": "G"}, {"family": "Monraz G\u00f3mez", "given": "Luis Crist\u00f3bal", "initials": "LC"}, {"family": "Somers", "given": "Julia", "initials": "J", "orcid": "0000-0001-9489-2246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b48974bc51204f63875b9efd092bc1bd.json"}}, {"family": "Hoch", "given": "Matti", "initials": "M", "orcid": "0000-0002-2486-0246", "researcher": {"href": 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"https://publications-covid19.scilifelab.se/researcher/568efa35a020457b90f3f313d004dd58.json"}}, {"family": "Ponce de Leon", "given": "Miguel", "initials": "M", "orcid": "0000-0002-7496-844X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9fe25b6b14ae4521a63c615fa6142075.json"}}, {"family": "Funahashi", "given": "Akira", "initials": "A", "orcid": "0000-0003-0605-239X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d17761419d74a31b088c3bd101c1df3.json"}}, {"family": "Hiki", "given": "Yusuke", "initials": "Y", "orcid": "0000-0001-6955-3867", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8977c92272dd4699873a2bc2ab5d8c86.json"}}, {"family": "Hiroi", "given": "Noriko", "initials": "N", "orcid": "0000-0002-0214-373X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4aff05ff5feb424f8884803732142a91.json"}}, {"family": "Yamada", "given": "Takahiro G", "initials": "TG", "orcid": "0000-0002-1665-1778", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2bacf1beecd94f8b99cf8f4279660a56.json"}}, {"family": "Dr\u00e4ger", "given": "Andreas", "initials": "A", "orcid": "0000-0002-1240-5553", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/846ba169210444f2816b6b9ab616169e.json"}}, {"family": "Renz", "given": "Alina", "initials": "A", "orcid": "0000-0003-3851-9978", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6fec830968244a7bbceacd4a6de8e56c.json"}}, {"family": "Naveez", "given": "Muhammad", "initials": "M", "orcid": "0000-0003-2437-2055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dfe41d31a2ca4cdfb4ffdc9336313a03.json"}}, {"family": "Bocskei", "given": "Zsolt", "initials": "Z", "orcid": "0000-0002-6105-2504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39081a56066543189b92ebf3f8d461fa.json"}}, 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"https://publications-covid19.scilifelab.se/researcher/2b82bd1326364f20b99c31bc4c87c928.json"}}, {"family": "Pico", "given": "Alexander R", "initials": "AR", "orcid": "0000-0001-5706-2163", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f0c2f9e7ae342b091262f25e50074b6.json"}}, {"family": "Evelo", "given": "Chris T", "initials": "CT", "orcid": "0000-0002-5301-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2dd7e54b2c56497a834ee9e803ee76d5.json"}}, {"family": "Gillespie", "given": "Marc E", "initials": "ME", "orcid": "0000-0002-5766-1702", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9ccfe4704504a99873bd800e86e59be.json"}}, {"family": "Stein", "given": "Lincoln D", "initials": "LD", "orcid": "0000-0002-1983-4588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e7d7a39c24c40f99f00639a9fdab10c.json"}}, {"family": "Hermjakob", "given": "Henning", "initials": "H", "orcid": "0000-0001-8479-0262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89303e87266b44fbaf33a811713257cd.json"}}, {"family": "D'Eustachio", "given": "Peter", "initials": "P", "orcid": "0000-0002-5494-626X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53d33c1e054540b8b8730e913dbb282b.json"}}, {"family": "Saez-Rodriguez", "given": "Julio", "initials": "J", "orcid": "0000-0002-8552-8976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/95931a9232ee4e82b01252e9ab31e8cd.json"}}, {"family": "Dopazo", "given": "Joaquin", "initials": "J", "orcid": "0000-0003-3318-120X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7701cf5d39f4d6cb455cd27ace48bb0.json"}}, {"family": "Valencia", "given": "Alfonso", "initials": "A", "orcid": "0000-0002-8937-6789", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9877cbb9a124eb0b99b5e1d8cde4752.json"}}, {"family": "Kitano", "given": "Hiroaki", "initials": "H", "orcid": "0000-0002-3589-1953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e945269c001427b9cce60f288d8c3bc.json"}}, {"family": "Barillot", "given": "Emmanuel", "initials": "E", "orcid": "0000-0003-2724-2002", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/601bf39565aa494dbf347a8f6af6d9c9.json"}}, {"family": "Auffray", "given": "Charles", "initials": "C", "orcid": "0000-0003-2226-7411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/653a07414125471a991ac5733bc1cfea.json"}}, {"family": "Balling", "given": "Rudi", "initials": "R", "orcid": "0000-0003-2902-5650", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e72fef5ff024aa0bc2cd5bf02add22f.json"}}, {"family": "Schneider", "given": "Reinhard", "initials": "R", "orcid": "0000-0002-8278-1618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/16d96bb94cd34671aa3f30868e37d6c7.json"}}, {"family": "COVID-19 Disease Map Community", "given": "", "initials": ""}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Mol Syst Biol", "issn": "1744-4292", "volume": "17", "issue": "10", "pages": "e10387", "issn-l": "1744-4292"}, "abstract": "We need to effectively combine the knowledge from surging literature with complex datasets to propose mechanistic models of SARS-CoV-2 infection, improving data interpretation and predicting key targets of intervention. Here, we describe a large-scale community effort to build an open access, interoperable and computable repository of COVID-19 molecular mechanisms. The COVID-19 Disease Map (C19DMap) is a graphical, interactive representation of disease-relevant molecular mechanisms linking many knowledge sources. Notably, it is a computational resource for graph-based analyses and disease modelling. To this end, we established a framework of tools, platforms and guidelines necessary for a multifaceted community of biocurators, domain experts, bioinformaticians and computational biologists. The diagrams of the C19DMap, curated from the literature, are integrated with relevant interaction and text mining databases. We demonstrate the application of network analysis and modelling approaches by concrete examples to highlight new testable hypotheses. This framework helps to find signatures of SARS-CoV-2 predisposition, treatment response or prioritisation of drug candidates. Such an approach may help deal with new waves of COVID-19 or similar pandemics in the long-term perspective.", "doi": "10.15252/msb.202110387", "pmid": "34664389", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-21T04:54:54.498Z", "modified": "2021-10-21T04:54:57.857Z"}, {"entity": "publication", "iuid": "a2ac4ed89b574e36a58271d2411b0d88", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2ac4ed89b574e36a58271d2411b0d88.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2ac4ed89b574e36a58271d2411b0d88"}}, "title": "COVID-19 and handwashing: Implications for water use in Sub-Saharan Africa.", "authors": [{"family": "Amuakwa-Mensah", "given": "Franklin", "initials": "F"}, {"family": "Klege", "given": "Rebecca Afua", "initials": "RA"}, {"family": "Adom", "given": "Philip Kofi", "initials": "PK"}, {"family": "K\u00f6hlin", "given": "Gunnar", "initials": "G"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Water Resour Econ", "issn": "2212-4284", "volume": "36", "pages": "100189", "issn-l": null}, "abstract": "Because the main modes of transmission of the COVID-19 virus are respiration and contact, WHO recommends frequent washing of hands with soap under running water for at least 20 s. This article investigates how the level of concern about COVID-19 affects the likelihood of washing hands frequently in sub-Saharan Africa. We discuss the implication of the findings for water-scarce environment. The study makes use of a unique survey dataset from 12 sub-Saharan African countries collected in April 2020 (first round) and May 2020 (second round) and employs an extended ordered probit model with endogenous covariate. The results show that the level of concern about the spread of the virus increases the likelihood of washing hands with soap under running water for a minimum of 20 s at least five times a day. The increase in the probability of handwashing due to concern about COVID-19, ranges from 3% for Benin to 6.3% for South Africa. The results also show heterogeneous effects across gender- and age-groups, locality and various water sources. However, in Africa, the sustainability of the handwashing protocol could be threatened by the severe water scarcity that exists in the region. To sustain frequent handwashing, sub-Saharan Africa needs an effective strategy for water management and supply.", "doi": "10.1016/j.wre.2021.100189", "pmid": "34745865", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2212-4284(21)00013-X"}, {"db": "pmc", "key": "PMC8563594"}], "notes": [], "created": "2021-11-26T15:34:51.447Z", "modified": "2021-11-26T15:34:51.482Z"}, {"entity": "publication", "iuid": "eb5532c9c30840e7ae31b631e10eb2ac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb5532c9c30840e7ae31b631e10eb2ac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb5532c9c30840e7ae31b631e10eb2ac"}}, "title": "Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19.", "authors": [{"family": "Aamodt", "given": "Anne Hege", "initials": "AH", "orcid": "0000-0002-2824-2760", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b21211bae394fef867be93f162d8ef8.json"}}, {"family": "H\u00f8gest\u00f8l", "given": "Einar August", "initials": "EA", "orcid": "0000-0001-8446-2111", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be2ccda7a98243e78919d6e58629b5cf.json"}}, {"family": "Popperud", "given": "Trine Haug", "initials": "TH"}, {"family": "Holter", "given": "Jan Cato", "initials": "JC", "orcid": "0000-0003-1618-5022", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7b6512c252a422badaaa120ee2aa700.json"}}, {"family": "Dyrhol-Riise", "given": "Anne Ma", "initials": "AM", "orcid": "0000-0003-4009-4032", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/051b91855a064394a525b898992aa834.json"}}, {"family": "Tonby", "given": "Kristian", "initials": "K", "orcid": "0000-0002-8465-1315", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dee8c27f3f184a52aaf4b1a82c0efe0e.json"}}, {"family": "Stiksrud", "given": "Birgitte", "initials": "B", "orcid": "0000-0001-9679-8181", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd511102a315446cb0fcef7e1a5b4f7b.json"}}, {"family": "Quist-Paulsen", "given": "Else", "initials": "E", "orcid": "0000-0002-1633-5660", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93114d4a49524fb4af2479a8ec268365.json"}}, {"family": "Berge", "given": "Tone", "initials": "T", "orcid": "0000-0002-5297-2034", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bae2754b3324238a3d36933f0b2d001.json"}}, {"family": "Barratt-Due", "given": "Andreas", "initials": "A", "orcid": "0000-0001-5408-7162", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f6cdc11b90949d2b825b76eee88333b.json"}}, {"family": "Aukrust", "given": "P\u00e5l", "initials": "P", "orcid": "0000-0002-6509-6221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e946d8e631c46f6b9613c7f73755e6d.json"}}, {"family": "Heggelund", "given": "Lars", "initials": "L", "orcid": "0000-0002-1669-1032", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9befa124c647487d803e8dba68495821.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/351fab09f6e24b9f9e6695da83947cb6.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e314740b02c344d2b336a9410e28041e.json"}}, {"family": "Harbo", "given": "Hanne Flinstad", "initials": "HF", "orcid": "0000-0002-6047-0122", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90fa41f3df4b40df903efcacad11b947.json"}}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "J Neurol", "issn": "1432-1459", "volume": "268", "issue": "10", "pages": "3574-3583", "issn-l": null}, "abstract": "To test the hypotheses that blood biomarkers for nervous system injury, serum concentrations of neurofilament light chain protein (NfL) and glial fibrillary acidic protein (GFAp) can serve as biomarkers for disease severity in COVID-19 patients.\n\nForty-seven inpatients with confirmed COVID-19 had blood samples drawn on admission for assessing serum biomarkers of CNS injury by Single molecule array (Simoa), NfL and GFAp. Concentrations of NfL and GFAp were analyzed in relation to symptoms, clinical signs, inflammatory biomarkers and clinical outcomes. We used multivariate linear models to test for differences in biomarker concentrations in the subgroups, accounting for confounding effects.\n\nIn total, 21% (n = 10) of the patients were admitted to an intensive care unit, and the overall mortality rate was 13% (n = 6). Non-survivors had higher serum concentrations of NfL (p < 0.001) upon admission than patients who were discharged alive both in adjusted analyses (p = 2.6 \u00d7 10-7) and unadjusted analyses (p = 0.001). The concentrations of NfL in non-survivors increased over repeated measurements; whereas, the concentrations in survivors were stable. The GFAp concentration was also significantly higher in non-survivors than survivors (p = 0.02).\n\nIncreased concentrations of NfL and GFAp in COVID-19 patients on admission may indicate increased mortality risk. Measurement of blood biomarkers for nervous system injury can be useful to detect and monitor CNS injury in COVID-19.", "doi": "10.1007/s00415-021-10517-6", "pmid": "33743046", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7980743"}, {"db": "pii", "key": "10.1007/s00415-021-10517-6"}], "notes": [], "created": "2021-03-22T10:17:46.101Z", "modified": "2023-06-19T14:57:19.636Z"}, {"entity": "publication", "iuid": "c66d19afa22c45fd98d6bf059cb208d8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c66d19afa22c45fd98d6bf059cb208d8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c66d19afa22c45fd98d6bf059cb208d8"}}, "title": "Biomarkers for central nervous system injury in cerebrospinal fluid are elevated in COVID-19 and associated with neurological symptoms and disease severity.", "authors": [{"family": "Virhammar", "given": "Johan", "initials": "J", "orcid": "0000-0001-9901-2949", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9db4ac69a3e8495ea8e71ae60042fa5c.json"}}, {"family": "N\u00e4\u00e4s", "given": "Anja", "initials": "A"}, {"family": "F\u00e4llmar", "given": "David", "initials": "D"}, {"family": "Cunningham", "given": "Janet L", "initials": "JL"}, {"family": "Klang", "given": "Andrea", "initials": "A"}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ"}, {"family": "Jackmann", "given": "Sven", "initials": "S"}, {"family": "Westman", "given": "Gabriel", "initials": "G"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Rostami", "given": "Elham", "initials": "E"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Eur J Neurol", "issn": "1468-1331", "issn-l": null, "volume": "28", "issue": "10", "pages": "3324-3331"}, "abstract": "Neurological symptoms have been frequently reported in hospitalized patients with coronavirus disease 2019 (COVID-19), and biomarkers of central nervous system (CNS) injury are reported to be increased in plasma but not extensively studied in cerebrospinal fluid (CSF). This study examined CSF for biomarkers of CNS injury and other pathology in relation to neurological symptoms and disease severity in patients with neurological manifestations of COVID-19.\n\nNineteen patients with neurological symptoms and mild to critical COVID-19 were prospectively included. Extensive analysis of CSF, including measurement of biomarkers of CNS injury (neurofilament light chain [NfL] protein, glial fibrillary acidic protein [GFAp], and total tau), was performed and compared to neurological features and disease severity.\n\nNeurological symptoms included altered mental status (42%), headache (42%), and central (21%) and peripheral weakness (32%). Two patients demonstrated minor pleocytosis, and four patients had increased immunoglobulin G levels in CSF. Neuronal autoantibody testing using commercial tests was negative in all patients. Increased CSF levels of NfL protein, total tau, and GFAp were seen in 63%, 37%, and 16% of patients, respectively. Increased NfL protein correlated with disease severity, time in intensive care, and level of consciousness. NfL protein in CSF was higher in patients with central neurological symptoms.\n\nAlthough limited by the small sample size, our data suggest that levels of NfL protein, GFAp, and total tau in CSF are commonly elevated in patients with COVID-19 with neurological symptoms. This is in contrast to the standard CSF workup where pathological findings are scarce. NfL protein, in particular, is associated with central neurological symptoms and disease severity.", "doi": "10.1111/ene.14703", "pmid": "33369818", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8518988"}], "notes": [], "created": "2021-01-07T13:15:08.321Z", "modified": "2021-12-12T18:06:16.091Z"}, {"entity": "publication", "iuid": "2b1f786eed0c4282b1e2f6ae144bf76d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b1f786eed0c4282b1e2f6ae144bf76d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b1f786eed0c4282b1e2f6ae144bf76d"}}, "title": "A longitudinal study on symptom duration and 60-day clinical course in non-hospitalised COVID-19 cases in Berlin, Germany, March to May, 2020.", "authors": [{"family": "Saad", "given": "Neil J", "initials": "NJ"}, {"family": "Moek", "given": "Felix", "initials": "F"}, {"family": "Steitz", "given": "Fabienne", "initials": "F"}, {"family": "Murajda", "given": "Lukas", "initials": "L"}, {"family": "B\u00e4rnighausen", "given": "Till", "initials": "T"}, {"family": "Zoller", "given": "Thomas", "initials": "T"}, {"family": "P\u00f6rtner", "given": "Kirsten", "initials": "K"}, {"family": "Muller", "given": "Nadine", "initials": "N"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "43", "issn-l": null}, "abstract": "BackgroundDetailed information on symptom duration and temporal course of patients with mild COVID-19 was scarce at the beginning of the COVID-19 pandemic.AimWe aimed to determine the longitudinal course of clinical symptoms in non-hospitalised COVID-19 patients in Berlin, Germany.MethodsBetween March and May 2020, 102 confirmed COVID-19 cases in home isolation notified in Berlin, Germany, were sampled using total population sampling. Data on 25 symptoms were collected during telephone consultations (a maximum of four consultations) with each patient. We collected information on prevalence and duration of symptoms for each day of the first 2 weeks after symptom onset and for day 30 and 60 after symptom onset.ResultsMedian age was 35 years (range 18-74), 57% (58/102) were female, and 37% (38/102) reported having comorbidities. During the first 2 weeks, most common symptoms were malaise (94%, 92/98), headache (71%, 70/98), and rhinitis (69%, 68/98). Malaise was present for a median of 11 days (IQR 7-14 days) with 35% (34/98) of cases still reporting malaise on day 14. Headache and muscle pain mostly occurred during the first week, whereas dysosmia and dysgeusia mostly occurred during the second week. Symptoms persisted in 41% (39/95) and 20% (18/88) of patients on day 30 and 60, respectively.ConclusionOur study shows that a significant proportion of non-hospitalised COVID-19 cases endured symptoms for at least 2 months. Further research is needed to assess the frequency of long-term adverse health effects in non-hospitalised COVID-19 patients.", "doi": "10.2807/1560-7917.ES.2021.26.43.2001757", "pmid": "34713798", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-11-01T19:51:46.148Z", "modified": "2021-11-01T19:51:46.163Z"}, {"entity": "publication", "iuid": "3ed4dababe18432292a120455da77843", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ed4dababe18432292a120455da77843.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ed4dababe18432292a120455da77843"}}, "title": "The Upper Respiratory Tract of Felids Is Highly Susceptible to SARS-CoV-2 Infection.", "authors": [{"family": "Kr\u00fcger", "given": "Nadine", "initials": "N", "orcid": "0000-0002-4413-8699", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/397f978cad79487e89676dc30b50f227.json"}}, {"family": "Rocha", "given": "Cheila", "initials": "C", "orcid": "0000-0002-0148-9405", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c49cd1df09cb49399d87e33722f400e8.json"}}, {"family": "Runft", "given": "Sandra", "initials": "S"}, {"family": "Kr\u00fcger", "given": "Johannes", "initials": "J"}, {"family": "F\u00e4rber", "given": "Iris", "initials": "I", "orcid": "0000-0002-3390-5880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61e578b4819a415d9db7daef5d2a8c55.json"}}, {"family": "Armando", "given": "Federico", "initials": "F"}, {"family": "Leitzen", "given": "Eva", "initials": "E", "orcid": "0000-0002-3818-9246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44e86d0862104a4aae31c94715ca130b.json"}}, {"family": "Brogden", "given": "Graham", "initials": "G", "orcid": "0000-0002-2306-7932", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3015adaef844c0bad26d535324e19d9.json"}}, {"family": "Gerold", "given": "Gisa", "initials": "G", "orcid": "0000-0002-1326-5038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39af3df98cf14f96baa155798617841b.json"}}, {"family": "P\u00f6hlmann", "given": "Stefan", "initials": "S", "orcid": "0000-0001-6086-9136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03c63bbe69c949748dc5ecd3ec438492.json"}}, {"family": "Hoffmann", "given": "Markus", "initials": "M", "orcid": "0000-0003-4603-7696", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b40ee42e4354ca99c33a2633bbbaed4.json"}}, {"family": "Baumg\u00e4rtner", "given": "Wolfgang", "initials": "W"}], "type": "journal article", "published": "2021-09-30", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "22", "issue": "19", "issn-l": null}, "abstract": "Natural or experimental infection of domestic cats and virus transmission from humans to captive predatory cats suggest that felids are highly susceptible to SARS-CoV-2 infection. However, it is unclear which cells and compartments of the respiratory tract are infected. To address this question, primary cell cultures derived from the nose, trachea, and lungs of cat and lion were inoculated with SARS-CoV-2. Strong viral replication was observed for nasal mucosa explants and tracheal air-liquid interface cultures, whereas replication in lung slices was less efficient. Infection was mainly restricted to epithelial cells and did not cause major pathological changes. Detection of high ACE2 levels in the nose and trachea but not lung further suggests that susceptibility of feline tissues to SARS-CoV-2 correlates with ACE2 expression. Collectively, this study demonstrates that SARS-CoV-2 can efficiently replicate in the feline upper respiratory tract ex vivo and thus highlights the risk of SARS-CoV-2 spillover from humans to felids.", "doi": "10.3390/ijms221910636", "pmid": "34638978", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijms221910636"}, {"db": "pmc", "key": "PMC8508926"}], "notes": [], "created": "2021-10-21T05:28:18.673Z", "modified": "2021-10-21T05:28:50.620Z"}, {"entity": "publication", "iuid": "d6dbde36b7d041d087bdd5e48bddf97a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d6dbde36b7d041d087bdd5e48bddf97a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d6dbde36b7d041d087bdd5e48bddf97a"}}, "title": "Global Prevalence of Adaptive and Prolonged Infections\u2019 Mutations in the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein", "authors": [{"family": "Lennerstrand", "given": "Johan", "initials": "J"}, {"family": "Palanisamy", "given": "Navaneethan", "initials": "N", "orcid": "0000-0003-0369-2316", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e92f0f2edcb4c8eaa66f55c59490717.json"}}], "type": "journal-article", "published": "2021-09-30", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "10", "pages": "1974", "issn-l": "1999-4915"}, "abstract": null, "doi": "10.3390/v13101974", "pmid": null, "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:30:11.056Z", "modified": "2021-10-26T18:30:11.115Z"}, {"entity": "publication", "iuid": "e6ae64a793f84661ac387675c53ac24e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6ae64a793f84661ac387675c53ac24e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6ae64a793f84661ac387675c53ac24e"}}, "title": "An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responses.", "authors": [{"family": "Mangsbo", "given": "Sara M", "initials": "SM", "orcid": "0000-0002-1355-2678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cf494629d8a4f9584ada4be16dff66b.json"}}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Laur\u00e9n", "given": "Ida", "initials": "I"}, {"family": "Lindsay", "given": "Robin", "initials": "R", "orcid": "0000-0001-7867-8653", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf1f32f9550141fb8c4ebbb0cbe09e51.json"}}, {"family": "Jernbom Falk", "given": "August", "initials": "A", "orcid": "0000-0002-7773-1851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40d944d7fa964f4292f10012356a2730.json"}}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Lord", "given": "Martin", "initials": "M", "orcid": "0000-0002-3238-3187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ddcd91137ed4f8c88b2beb2db340081.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "D\u00f6nnes", "given": "Pierre", "initials": "P"}, {"family": "Christoffersson", "given": "Gustaf", "initials": "G"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "evaluation study", "published": "2021-09-30", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "9", "pages": "e0258041"}, "abstract": "Numerous assays evaluating serological and cellular responses have been developed to characterize immune responses against SARS-CoV-2. Serological assays are both cost- and time-effective compared to cellular assays, but cellular immune responses may provide a diagnostic value to determine previous SARS-CoV-2 infection in seronegative individuals. However, potential cross-reactive T cell responses stemming from prior encounters with human coronaviruses (HCoVs) may affect assay specificity. In this study, we evaluated the specificity and sensitivity of a SARS-CoV-2 IFN-\u03b3 Release Assay (IGRA) based on the FluoroSpot method employing commercially available SARS-CoV-2-specific peptide pools, as well as an in-house designed SARS-CoV-2 peptide pool restricted to 5 amino acid stretches or less aligning with endemic HCoVs. Blood samples were obtained from healthcare workers (HCW) 5-6 months post SARS-CoV-2 spike (S) IgG and nucleocapsid (N) IgG dual seroconversion (n = 187) and HCW who had been S IgG and N IgG dual seronegative at repeated occasions, including the current sampling time point (n = 102). In addition, samples were obtained 4 to 5 months post infection from 55 polymerase chain reaction (PCR)-confirmed COVID-19 patients. Assay specificity and sensitivity were calculated with serology as a reference standard for HCW. The in-house generated peptide pool displayed a specificity of 96.1%, while the commercially available peptide pools displayed specificities of 80.4% and 85.3%, respectively. Sensitivity was higher in a cohort of previously hospitalized COVID-19 patients (96.4% and 84.0% for the commercially available peptide pools and 92.7% for the in-house generated peptide pool) compared to the HCW cohort (92.0% and 66.8% for the commercially available peptide pools and 76.0% for the in-house generated peptide pool). Based on these findings, the individual diagnostic value of T cell immune responses against SARS-CoV-2 currently appears to be limited but remain an important research tool ahead.", "doi": "10.1371/journal.pone.0258041", "pmid": "34591918", "labels": {"Category: Imaging": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-19070"}, {"db": "pmc", "key": "PMC8483319"}], "notes": [], "created": "2021-11-18T15:12:02.239Z", "modified": "2021-11-19T10:47:39.135Z"}, {"entity": "publication", "iuid": "6f7064f617d945d68996fc33dbc10b00", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f7064f617d945d68996fc33dbc10b00.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f7064f617d945d68996fc33dbc10b00"}}, "title": "SARS-CoV-2 integral membrane proteins shape the serological responses of COVID-19 patients.", "authors": [{"family": "Martin", "given": "Sophie", "initials": "S"}, {"family": "Heslan", "given": "Christopher", "initials": "C"}, {"family": "J\u00e9gou", "given": "Gw\u00e9na\u00eble", "initials": "G"}, {"family": "Eriksson", "given": "Leif A", "initials": "LA"}, {"family": "Le Gallo", "given": "Matthieu", "initials": "M"}, {"family": "Thibault", "given": "Vincent", "initials": "V"}, {"family": "Chevet", "given": "Eric", "initials": "E"}, {"family": "Godey", "given": "Florence", "initials": "F"}, {"family": "Avril", "given": "Tony", "initials": "T"}], "type": "journal article", "published": "2021-09-29", "journal": {"title": "iScience", "issn": "2589-0042", "pages": "103185", "issn-l": "2589-0042"}, "abstract": "SARS-CoV-2 pandemic has elicited a unique mobilization of the scientific community to develop efficient tools to understand and combat infection. Like other coronavirae, SARS-CoV-2 hijacks host cell secretory machinery to produce viral proteins that compose the nascent virions; including Spike (S), Envelope (E) and Membrane (M) proteins, the most exposed transmembrane proteins to the host immune system. As antibody response is part of the anti-viral immune arsenal, we investigate the immunogenic potential of S, E and M using a human cell-based system to mimic membrane insertion and N-glycosylation. Both S and M elicit specific Ig production in SARS-CoV-2 patients. Patients with moderate and severe diseases exhibit elevated Ig responses. Finally, reduced Ig binding was observed with Spike G614 compared to D614 variant. Altogether, our assay points towards an unexpected immune response against M and represents a powerful tool to test humoral responses against actively evolving SARS-CoV-2 variants and vaccine effectiveness.", "doi": "10.1016/j.isci.2021.103185", "pmid": "34604721", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(21)01153-6"}, {"db": "pmc", "key": "PMC8479324"}, {"db": "URL", "key": "https://data.mendeley.com/datasets/69tvkst9ct/1", "description": "clinical and raw data related to serological assay"}], "notes": [], "created": "2021-10-11T17:56:55.960Z", "modified": "2021-10-15T07:54:32.174Z"}, {"entity": "publication", "iuid": "b2e64a7af9894313b4e54453e26ffae7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b2e64a7af9894313b4e54453e26ffae7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b2e64a7af9894313b4e54453e26ffae7"}}, "title": "High level of protection against COVID-19 after two doses of BNT162b2 vaccine in the working age population \u2013 first results from a cohort study in Southern Sweden", "authors": [{"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J", "orcid": "0000-0003-1883-2000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e88fdca336ae41c891f0a46e2481b67f.json"}}, {"family": "Inghammar", "given": "Malin", "initials": "M", "orcid": "0000-0003-2995-1312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4ab710428614cccb2a537ecab31d0a0.json"}}, {"family": "Moghaddassi", "given": "Mahnaz", "initials": "M", "orcid": "0000-0002-0844-4736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a219bde5ba8a4f3f8655ada08d749885.json"}}, {"family": "Rasmussen", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1588-5473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c760e8d21ae441ba236f86e6185d392.json"}}, {"family": "Malmqvist", "given": "Ulf", "initials": "U"}, {"family": "Kahn", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-5566-6350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42eda71f3775400599febc10a4e7359c.json"}}], "type": "journal-article", "published": "2021-09-29", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4235", "issn-l": null, "volume": null, "issue": null, "pages": "1-6"}, "abstract": "Vaccine effectiveness against COVID-19 needs to be assessed in diverse real-world population settings.\n\nA cohort study of 805,741 residents in Sk\u00e5ne county, Southern Sweden, aged 18-64 years, of whom 26,587 received at least one dose of the BNT162b2 vaccine. Incidence rates of COVID-19 were estimated in sex- and age-adjusted analysis and stratified in two-week periods with substantial community spread of the disease.\n\nThe estimated vaccine effectiveness in preventing infection \u22657 days after second dose was 86% (95% CI 72-94%) but only 42% (95% CI 14-63%) \u226514 days after a single dose. No difference in vaccine effectiveness was observed between females and males. Having a prior positive test was associated with 91% (95% CI 85-94%) effectiveness against new infection among the unvaccinated.\n\nA satisfactory effectiveness of BNT162b2 after the second dose was suggested, but with possibly substantially lower effect before the second dose.", "doi": "10.1080/23744235.2021.1982144", "pmid": "34586934", "labels": {"Category: Biochemistry": null, "Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null, "Funder: VR": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC8500302"}], "notes": [], "created": "2021-10-11T18:09:45.592Z", "modified": "2021-11-29T06:13:18.964Z"}, {"entity": "publication", "iuid": "80e9261113314fb7856ca4ae73f8dc27", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/80e9261113314fb7856ca4ae73f8dc27.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/80e9261113314fb7856ca4ae73f8dc27"}}, "title": "Solidarity and polarisation regarding COVID-19 and related risks - A thematic analysis of comments from an international survey.", "authors": [{"family": "Stjernsw\u00e4rd", "given": "Sigrid", "initials": "S"}, {"family": "Glasdam", "given": "Stinne", "initials": "S"}], "type": "journal article", "published": "2021-09-28", "journal": {"title": "Soc Sci Humanit Open", "issn": "2590-2911", "volume": "4", "issue": "1", "pages": "100211", "issn-l": null}, "abstract": "COVID-19 represents a risk to people's life and societies in their current shapes and functions, with institutionalised responses redefining everyday life. Crises in society can induce fear and tensions that can unite and divide people, inducing acts of solidarity and polarisation. The study explored articulations of solidarity and polarisation in relation to the COVID-19 pandemic and related risks. A Foucault-inspired thematic analysis was pursued on qualitative data from an international survey about COVID-19 and social media. The analysis resulted in four themes illustrating articulations of solidarity and polarisation related to the COVID-19 pandemic. The analysis showed solidarity and polarisation as each other's premise and contradiction. Socialisation into a 'new normal' was characterised by the balance between solidarity and polarisation as well as aspirations to enhance future solidarity. The study illustrated that social media functioned as social technology for control and manipulation towards social normalisation. However, it was also used to voice attempts to rectify (or overthrow) the dominant medico-political discourse and norms with own preferences, opinions and a functioning daily life. In short, the articulations and social media uses could be interpreted as expressions of power and counter-power.", "doi": "10.1016/j.ssaho.2021.100211", "pmid": "34604736", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2590-2911(21)00107-8"}, {"db": "pmc", "key": "PMC8479510"}], "notes": [], "created": "2021-10-11T17:56:21.609Z", "modified": "2021-10-11T17:56:21.646Z"}, {"entity": "publication", "iuid": "321676cd0e76407a9091ffc38c3adc4e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/321676cd0e76407a9091ffc38c3adc4e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/321676cd0e76407a9091ffc38c3adc4e"}}, "title": "Risk for SARS-CoV-2 infection in healthcare workers outside hospitals: A real-life immuno-virological study during the first wave of the COVID-19 epidemic.", "authors": [{"family": "Fr\u00f6berg", "given": "Maria", "initials": "M"}, {"family": "Hassan", "given": "Sadaf Sakina", "initials": "SS"}, {"family": "Pimenoff", "given": "Ville N", "initials": "VN"}, {"family": "Akterin", "given": "Susanne", "initials": "S"}, {"family": "Conneryd Lundgren", "given": "Kalle", "initials": "K"}, {"family": "Elfstr\u00f6m", "given": "K Miriam", "initials": "KM"}, {"family": "Dillner", "given": "Joakim", "initials": "J", "orcid": "0000-0001-8588-6506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bbb8b0ca5dc648e0b80c1de224b26c69.json"}}], "type": "journal article", "published": "2021-09-28", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "9", "pages": "e0257854", "issn-l": "1932-6203"}, "abstract": "Most COVID-19 related infections and deaths may occur in healthcare outside hospitals. Here we explored SARS-CoV-2 infections among healthcare workers (HCWs) in this setting.\n\nAll healthcare providers in Stockholm, Sweden were asked to recruit HCWs at work for a study of past or present SARS-CoV-2 infections among HCWs. Study participants This study reports the results from 839 HCWs, mostly employees of primary care centers, sampled in June 2020.\n\nSARS-CoV-2 seropositivity was found among 12% (100/839) of HCWs, ranging from 0% to 29% between care units. Seropositivity decreased by age and was highest among HCWs <40 years of age. Within this age group there was 19% (23/120) seropositivity among women and 11% (15/138) among men (p<0.02). Current infection, as measured using PCR, was found in only 1% and the typical testing pattern of pre-symptomatic potential \"superspreaders\" found in only 2/839 subjects.\n\nPrevious SARS-CoV-2 infections were common among younger HCWs in this setting. Pre-symptomatic infection was uncommon, in line with the strong variability in SARS-CoV-2 exposure between units. Prioritizing infection prevention and control including sufficient and adequate personal protective equipment, and vaccination for all HCWs are important to prevent nosocomial infections and infections as occupational injuries during an ongoing pandemic.", "doi": "10.1371/journal.pone.0257854", "pmid": "34582483", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-17200"}, {"db": "pmc", "key": "PMC8478233"}], "notes": [], "created": "2021-10-11T18:07:24.488Z", "modified": "2021-10-11T18:07:24.511Z"}, {"entity": "publication", "iuid": "b63a0c526c9045eb9f4dddb326b2f5f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b63a0c526c9045eb9f4dddb326b2f5f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b63a0c526c9045eb9f4dddb326b2f5f2"}}, "title": "Post-Traumatic Stress Disorder in Chinese Teachers during COVID-19 Pandemic: Roles of Fear of COVID-19, Nomophobia, and Psychological Distress.", "authors": [{"family": "Kukreti", "given": "Shikha", "initials": "S", "orcid": "0000-0002-8370-3988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d0daa4b90a164aaa8acfc4f1cebb7fd3.json"}}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK", "orcid": "0000-0003-0530-8138", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d442447b551649d8a5372c6bf0075c91.json"}}, {"family": "Strong", "given": "Carol", "initials": "C"}, {"family": "Chen", "given": "I-Hua", "initials": "I"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Ko", "given": "Nai-Ying", "initials": "N"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Chen", "given": "Yu-Pin", "initials": "Y"}, {"family": "Kuo", "given": "Yi-Jie", "initials": "Y"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-09-28", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "issn-l": null, "volume": "9", "issue": "10", "pages": null}, "abstract": "There are limited data concerning the prevalence of post-traumatic stress disorder (PTSD) among teachers. Therefore, the present study estimated the prevalence of PTSD among mainland Chinese teachers during the COVID-19 pandemic and to construct a model with mediation and moderation effects to explain the PTSD. Data collection was conducted in schools in the Jiangxi province between October and November 2020 among k-12 schoolteachers. An online survey, including five different psychometric scales, was used to collect data. All participants were assessed for PTSD using the Chinese version of the PTSD Checklist for DSM-5 (PCL-5). Hayes' PROCESS Model 8 was used to examine the potential factors explaining a higher PTSD scores. A total of 2603 teachers from k-12 schools participated. With the cutoff score at 31, the prevalence of PTSD was 12.3% but decreased to 1.0% when the cutoff score was at 49. Nomophobia moderated the effects of Fear of COVID-19 Scale on PTSD. The findings suggest that fear of COVID-19 among teachers leads to PTSD via psychological distress, highlighting the moderating effect of nomophobia in this association. Based on the study's findings, psychological interventions and educational training are needed to reduce fear among teachers at higher risk of developing PTSD.", "doi": "10.3390/healthcare9101288", "pmid": "34682968", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "healthcare9101288"}], "notes": [], "created": "2021-10-26T18:17:05.359Z", "modified": "2022-02-17T09:44:49.441Z"}, {"entity": "publication", "iuid": "18ed2ce5f25849da929c9e365ae4ec05", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18ed2ce5f25849da929c9e365ae4ec05.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18ed2ce5f25849da929c9e365ae4ec05"}}, "title": "A Retrospective Cross-Sectional Study Assessing Self-Reported Adverse Events following Immunization (AEFI) of the COVID-19 Vaccine in Bangladesh", "authors": [{"family": "Sultana", "given": "Arifa", "initials": "A", "orcid": "0000-0002-5855-8731", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b70e8f78af140dcb43d8c1ecf01232f.json"}}, {"family": "Shahriar", "given": "Saimon", "initials": "S", "orcid": "0000-0003-1460-3104", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f11efd633e6460a89dc1737e21c2fec.json"}}, {"family": "Tahsin", "given": "Md Rafat", "initials": "MR"}, {"family": "Mim", "given": "Sabiha Rahman", "initials": "SR"}, {"family": "Fatema", "given": "Kazi Rubiya", "initials": "KR", "orcid": "0000-0002-8368-0798", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f98d252b78e643d48f24a19d85c94d65.json"}}, {"family": "Saha", "given": "Ananya", "initials": "A"}, {"family": "Yesmin", "given": "Fahmida", "initials": "F"}, {"family": "Bahar", "given": "Nasiba Binte", "initials": "NB", "orcid": "0000-0002-5981-3220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3407484c9fc419eaccb9eff656148cc.json"}}, {"family": "Samodder", "given": "Mithun", "initials": "M", "orcid": "0000-0001-6057-7838", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09d49d33289245208488f07cd60cc1c4.json"}}, {"family": "Mamun", "given": "Md Ariful Haque", "initials": "MAH", "orcid": "0000-0002-9123-5272", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9c66bede129447b95970d7679c0dbce.json"}}, {"family": "Aknur Rahman", "given": "Md", "initials": "M"}, {"family": "Ferdousy", "given": "Sonia", "initials": "S"}, {"family": "Akter", "given": "Tahmina", "initials": "T"}, {"family": "Aktar", "given": "Fahima", "initials": "F"}, {"family": "Kuddus", "given": "Md Ruhul", "initials": "MR", "orcid": "0000-0002-7038-3399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6d42cef0bfa4239be0b59e947691ad2.json"}}, {"family": "Rahman", "given": "Md Mustafizur", "initials": "MM", "orcid": "0000-0001-8585-263X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/854727a42e374690931b6200ef95ac32.json"}}, {"family": "Sarker", "given": "Md Moklesur Rahman", "initials": "MMR", "orcid": "0000-0001-9795-0608", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86b27674f7f34e5993d6d26b752860c2.json"}}, {"family": "B\u00fcy\u00fcker", "given": "Sultan Mehtap", "initials": "SM"}, {"family": "Chowdhury", "given": "Jakir Ahmed", "initials": "JA"}, {"family": "Chowdhury", "given": "Abu Asad", "initials": "AA"}, {"family": "Kabir", "given": "Shaila", "initials": "S"}, {"family": "Hossain", "given": "Md Akter", "initials": "MA"}, {"family": "Amran", "given": "Md Shah", "initials": "MS"}], "type": "journal-article", "published": "2021-09-28", "journal": {"title": "Vaccines", "issn": "2076-393X", "volume": "9", "issue": "10", "pages": "1090", "issn-l": null}, "abstract": null, "doi": "10.3390/vaccines9101090", "pmid": null, "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-26T18:29:44.988Z", "modified": "2021-10-26T18:29:45.283Z"}, {"entity": "publication", "iuid": "752e3e4deaa8429fa08ad1282d83045c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/752e3e4deaa8429fa08ad1282d83045c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/752e3e4deaa8429fa08ad1282d83045c"}}, "title": "The untold story of the COVID-19 pandemic: perceptions and views towards social stigma and bullying in the shadow of COVID-19 illness in Jordan.", "authors": [{"family": "Akour", "given": "Amal", "initials": "A", "orcid": "0000-0002-2789-8514", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7afcf3838a0e4150af12424aabdc69ed.json"}}, {"family": "AlMuhaissen", "given": "Suha A", "initials": "SA"}, {"family": "Nusair", "given": "Mohammad B", "initials": "MB"}, {"family": "Al-Tammemi", "given": "Ala'a B", "initials": "AB"}, {"family": "Mahmoud", "given": "Nouf N", "initials": "NN"}, {"family": "Jalouqa", "given": "Sarah", "initials": "S"}, {"family": "Alrawashdeh", "given": "Maissa N", "initials": "MN"}], "type": "journal article", "published": "2021-09-27", "journal": {"title": "SN Soc Sci", "issn": "2662-9283", "volume": "1", "issue": "9", "pages": "240", "issn-l": null}, "abstract": "Stigmatization towards COVID-19 patients can lead to negative outcomes like social exclusion and bullying, and it may hinder the willingness of people to undergo testing. This study aimed to measure and explore the perception of stigmatization and bullying towards COVID-19 patients in Jordan. This was a web-based cross-sectional survey. Participants were recruited from social media platforms employing a snowball convenience sampling. The perception of bullying, beliefs regarding social consequences of infection, views on measures towards violators of patients' privacy, and how to reduce the stigma were assessed by self-reported measures. 397 participants returned completed questionnaires. The majority of respondents believed that COVID-19 patients in Jordan are getting bullied (n = 255, 64.3%) and over 80% believed that people enjoy sharing identities, or news about COVID-19 patients. Although most respondents had adequate knowledge regarding transmission/prevention of COVID-19, they believed that all or some of the COVID-19 patients practiced something wrong to get infected (n = 358, 90.2%). Moreover, 86.9% of respondents reported that people in Jordan were crossing their lines with bullying behaviors towards COVID-19 patients. However, these negative views would not discourage most respondents to get tested and follow the government's instructions if they or any of their acquaintances were suspected to be infected. Our study sheds the light on a high degree of stigma and bullying of COVID-19 patients during the early stage of the pandemic in Jordan. Hence, there is a need to develop and implement effective anti-stigma/anti-bullying campaigns that refute the misperception, raise public knowledge about COVID-19, and spread encouraging messages.", "doi": "10.1007/s43545-021-00252-0", "pmid": "34693341", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "252"}, {"db": "pmc", "key": "PMC8475478"}], "notes": [], "created": "2021-10-26T18:24:07.111Z", "modified": "2021-10-26T18:24:19.356Z"}, {"entity": "publication", "iuid": "7dadb54b658943c599dfcd20763423e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7dadb54b658943c599dfcd20763423e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7dadb54b658943c599dfcd20763423e7"}}, "title": "Effects of the COVID-19 Health Crisis on Sports Practice, Life Quality, and Emotional Status in Spanish High-Performance Athletes.", "authors": [{"family": "Conde", "given": "Elena", "initials": "E"}, {"family": "Mart\u00ednez-Aranda", "given": "Luis Manuel", "initials": "LM"}, {"family": "Sanz", "given": "Gema", "initials": "G"}, {"family": "L\u00f3pez de Subijana", "given": "Cristina", "initials": "C"}, {"family": "S\u00e1nchez-Pato", "given": "Antonio", "initials": "A"}, {"family": "D\u00edaz-Aroca", "given": "\u00c1lvaro", "initials": "\u00c1"}, {"family": "Leiva-Arcas", "given": "Alejandro", "initials": "A"}, {"family": "Garc\u00eda-Roca", "given": "Juan Alfonso", "initials": "JA"}, {"family": "Ramis", "given": "Yago", "initials": "Y"}, {"family": "Torregrossa", "given": "Miquel", "initials": "M"}], "type": "journal article", "published": "2021-09-27", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "12", "issue": null, "pages": "736499"}, "abstract": "Spain is one of the many countries highly affected by the COVID-19 crisis, establishing very restrictive measures with a complete lockdown for more than 3 months. This situation forced the complete closure of sport practice and national or international competitions, leading to a negative impact on physical and psychological health of high-performance athletes. Therefore, the objectives of this study were (a) to determine the effects of the COVID-19 health crisis on Spanish high-performance athletes in terms of sports practice, life quality, and emotional state and (b) to identify the profile with the greatest difficulties during and after the lockdown. A sample of 130 high-performance athletes aged between 18 and 34 years (67 women and 63 men) participated in this study (83.1% achieved a medal in National-International elite competitions; 86.9% were considered student-athletes). Measures included socio-demographic data through a 5-dimension ad hoc survey: physical activity and exercise using an adapted version from the International Physical Activity Questionnaire (IPAQ); health status and limitations using an adapted version of SF-12 Health Questionnaire; Perceived stress (Short-PSS); and Mood States (29-item POMS). All participants have shown a significant decrease pre-post-lockdown in both health and performance perception, especially in women, individual athletes, medalists, and student-athletes. Strong limitations of training, attention, and motivation as well as a moderate negative emotional state during lockdown were reported, in women, individual athletes, medalists, and student-athletes. Even with an improved emotional state and energy level in the post-lockdown period, moderate-to-high stress scores were reported by women and medalists. Our findings highlight the importance of paying attention to the physical and psychological health of elite athletes on three profiles: team athletes (due to social distance), student-athletes (dual-career issues), and women athletes (prevalence of implicit gender inequalities in sport).", "doi": "10.3389/fpsyg.2021.736499", "pmid": "34646217", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8503513"}], "notes": [], "created": "2021-10-21T05:06:54.003Z", "modified": "2022-02-17T09:41:26.123Z"}, {"entity": "publication", "iuid": "d097b7933e1548aa946c8a6664f08eef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d097b7933e1548aa946c8a6664f08eef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d097b7933e1548aa946c8a6664f08eef"}}, "title": "Current international trends in the treatment of multiple sclerosis in children-Impact of the COVID-19 pandemic.", "authors": [{"family": "Sandesj\u00f6", "given": "Fredrik", "initials": "F"}, {"family": "Wassmer", "given": "Evangeline", "initials": "E"}, {"family": "Deiva", "given": "Kumaran", "initials": "K"}, {"family": "Amato", "given": "Maria Pia", "initials": "MP"}, {"family": "Chitnis", "given": "Tanuja", "initials": "T"}, {"family": "Hemingway", "given": "Cheryl", "initials": "C"}, {"family": "Krupp", "given": "Lauren", "initials": "L"}, {"family": "Pohl", "given": "Daniela", "initials": "D"}, {"family": "Rostasy", "given": "Kevin", "initials": "K"}, {"family": "Waubant", "given": "Emanuelle", "initials": "E"}, {"family": "Banwell", "given": "Brenda", "initials": "B"}, {"family": "Wickstr\u00f6m", "given": "Ronny", "initials": "R"}], "type": "journal article", "published": "2021-09-27", "journal": {"title": "Mult Scler Relat Disord", "issn": "2211-0356", "volume": "56", "pages": "103277", "issn-l": null}, "abstract": "Only recently has the first disease-modifying therapy been approved for children with multiple sclerosis (MS) and practice patterns including substantial off-label use have evolved. Understanding attitudes towards treatment of paediatric MS and whether this has changed due to the ongoing COVID-19 pandemic is vital to guide future therapeutic trials and for developing guidelines that reflect practice.\n\nWe performed an online survey within the International Paediatric Multiple Sclerosis Study Group between July and September 2020. The survey was sent to 130 members from 25 countries and consisted of five sections: demographic data, treatment, disease modifying therapies and COVID-19, outcome and three patient cases.\n\nThe survey was completed by 66 members (51%), both paediatric neurologists and adult neurologists. Fingolimod and \u03b2-interferons were the most frequently used disease-modifying therapies, especially among paediatric neurologists. Almost a third (31%) of respondents had altered their prescribing practice due to COVID-19, in particular at the beginning of the pandemic.\n\nThe survey results indicate a tendency of moving from the traditional escalation therapy starting with injectables towards an early start with newer, highly effective disease modifying therapies. The COVID-19 pandemic only slightly affected prescribing patterns and treatment choices in paediatric MS.", "doi": "10.1016/j.msard.2021.103277", "pmid": "34624643", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2211-0348(21)00544-7"}], "notes": [], "created": "2021-10-10T15:03:50.886Z", "modified": "2021-10-10T15:03:50.911Z"}, {"entity": "publication", "iuid": "65abebe3c4d04d1f875bdfda78b65758", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65abebe3c4d04d1f875bdfda78b65758.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65abebe3c4d04d1f875bdfda78b65758"}}, "title": "Increased Risks of Death and Hospitalization in Influenza/Pneumonia and Sepsis for Individuals Affected by Psychotic Disorders, Bipolar Disorders, and Single Manic Episodes: A Retrospective Cross-Sectional Study.", "authors": [{"family": "Nilsson", "given": "Niklas Harry", "initials": "NH"}, {"family": "Bendix", "given": "Marie", "initials": "M"}, {"family": "\u00d6hlund", "given": "Louise", "initials": "L"}, {"family": "Widerstr\u00f6m", "given": "Micael", "initials": "M", "orcid": "0000-0002-1483-4255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ad36fa63a334e3b91499527bb6d5659.json"}}, {"family": "Werneke", "given": "Ursula", "initials": "U", "orcid": "0000-0002-5023-3254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eed3b002ddb4cbba141cbfdc8d3f032.json"}}, {"family": "Maripuu", "given": "Martin", "initials": "M", "orcid": "0000-0001-7868-8894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f85873e152d421eba74e23054d0ff1e.json"}}], "type": "journal article", "published": "2021-09-26", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "10", "issue": "19", "pages": null}, "abstract": "Individuals with severe mental disorders (SMDs) such as psychotic disorders, bipolar disorders, and single manic episodes have increased mortality associated with COVID-19 infection. We set up a population-based study to examine whether individuals with SMD also had a higher risk of hospitalization and death from other infectious conditions. Anonymized and summarized data from multiple Swedish patient registers covering the entire Swedish population were supplied by the Swedish National Board of Health and Welfare. The frequencies of hospitalizations and deaths associated with influenza/pneumonia and sepsis in individuals with SMD were compared with the rest of the population during 2018-2019. Possible contributing comorbidities were also examined, of which diabetes, cardiovascular disease, chronic lung disease, and hypertension were chosen. A total of 7,780,727 individuals were included in the study; 97,034 (1.2%) cases with SMD and 7,683,693 (98.8%) controls. Individuals with SMD had increased risk of death associated with influenza/pneumonia (OR = 2.06, 95% CI [1.87-2.27]) and sepsis (OR = 1.61, 95% CI [1.38-1.89]). They also had an increased risk of hospitalization associated with influenza/pneumonia (OR = 2.12, 95% CI [2.03-2.20]) and sepsis (OR = 1.89, 95% CI [1.75-2.03]). Our results identify a need for further evaluation of whether these individuals should be included in prioritized risk groups for vaccination against infectious diseases other than COVID-19.", "doi": "10.3390/jcm10194411", "pmid": "34640430", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "jcm10194411"}, {"db": "pmc", "key": "PMC8509221"}], "notes": [], "created": "2021-10-21T05:09:08.038Z", "modified": "2022-02-17T09:42:49.284Z"}, {"entity": "publication", "iuid": "2d573fe40a9649649525c7d6641a5a59", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d573fe40a9649649525c7d6641a5a59.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d573fe40a9649649525c7d6641a5a59"}}, "title": "Covid-19 in patients with chronic lymphocytic leukemia: clinical outcome and B- and T-cell immunity during 13 months in consecutive patients.", "authors": [{"family": "Blixt", "given": "Lisa", "initials": "L"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "Johansson", "given": "Hemming", "initials": "H"}, {"family": "Kjellander", "given": "Christian", "initials": "C"}, {"family": "Mravinacova", "given": "Sara", "initials": "S", "orcid": "0000-0003-1848-910X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fc9538cb055479494e5595ed901546a.json"}}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Palma", "given": "Marzia", "initials": "M", "orcid": "0000-0003-4287-3179", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a4c445a486340619a33ab910011d64a.json"}}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE", "orcid": "0000-0003-1907-3392", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26a3bf24bd044fbda8ffa0c89974bdfe.json"}}, {"family": "Stromberg", "given": "Olga", "initials": "O"}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M", "orcid": "0000-0002-3793-4064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4bc179656eb442f9ac9dc72c8c6841d.json"}}, {"family": "Zain", "given": "Rula", "initials": "R", "orcid": "0000-0001-8327-846X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5a5815a733a4677b9f38403738a8741.json"}}, {"family": "Hansson", "given": "Lotta", "initials": "L", "orcid": "0000-0001-6614-5737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96cb28e556c643b99c77ce78754738af.json"}}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A", "orcid": "0000-0001-6489-4865", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d91b9eda8764ffea7f7926029c806d2.json"}}], "type": "journal article", "published": "2021-09-25", "journal": {"title": "Leukemia", "issn": "1476-5551", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "We studied clinical and immunological outcome of Covid-19 in consecutive CLL patients from a well-defined area during month 1-13 of the pandemic. Sixty patients (median age 71 y, range 43-97) were identified. Median CIRS was eight (4-20). Patients had indolent CLL (n = 38), had completed (n = 12) or ongoing therapy (n = 10). Forty-six patients (77%) were hospitalized due to severe Covid-19 and 11 were admitted to ICU. Severe Covid-19 was equally distributed across subgroups irrespective of age, gender, BMI, CLL status except CIRS (p < 0.05). Fourteen patients (23%) died; age \u226575 y was the only significant risk factor (p < 0.05, multivariate analysis with limited power). Comparing month 1-6 vs 7-13 of the pandemic, deaths were numerically reduced from 32% to 18%, ICU admission from 37% to 15% whereas hospitalizations remained frequent (86% vs 71%). Seroconversion occurred in 33/40 patients (82%) and anti-SARS-CoV-2 antibodies were detectable at six and 12 months in 17/22 and 8/11 patients, respectively. Most (13/17) had neutralizing antibodies and 19/28 had antibodies in saliva. SARS-CoV-2-specific T-cells (ELISpot) were detected in 14/17 patients. Covid-19 continued to result in high admission even among consecutive and young early- stage CLL patients. A robust and durable B and/or T cell immunity was observed in most convalescents.", "doi": "10.1038/s41375-021-01424-w", "pmid": "34564699", "labels": {"Research Area: High-throughput and high-content serology": null, "Funder: VR": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41375-021-01424-w"}, {"db": "pmc", "key": "PMC8475381"}], "notes": [], "created": "2021-11-18T15:53:16.064Z", "modified": "2021-12-12T18:10:28.317Z"}, {"entity": "publication", "iuid": "8828134f28fd4f4ca34b1436ec27ca9d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8828134f28fd4f4ca34b1436ec27ca9d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8828134f28fd4f4ca34b1436ec27ca9d"}}, "title": "Meaning-Making Coping Methods among Bereaved Parents: A Pilot Survey Study in Sweden.", "authors": [{"family": "Ahmadi", "given": "Fereshteh", "initials": "F", "orcid": "0000-0002-8823-6434", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f4f676633f24637b135c494dcb33cc9.json"}}, {"family": "Zandi", "given": "Saeid", "initials": "S", "orcid": "0000-0003-1272-7170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a941295613dc468e8282c9f8f157a4b6.json"}}], "type": "journal article", "published": "2021-09-24", "journal": {"title": "Behav Sci (Basel)", "issn": "2076-328X", "issn-l": null, "volume": "11", "issue": "10", "pages": null}, "abstract": "The death of a child may result in traumatizing forms of grief, and meaning-making coping with loss seems to be important in prevention of intense psychosocial problems among bereaved parents. The aim of this quantitative pilot study was to discover the divergent meaning-making coping methods used by bereaved parents in Sweden. In doing so, 162 respondents were selected using a convenience sampling method, and they responded to the modified version of RCOPE. The study revealed that the strategies talking to others about their feelings, pondering the meaning of life alone, and being in nature for greater emotional affiliation, i.e., what we call secular existential coping methods, have been the most used meaning-making coping methods among Swedish mourning parents. While explaining the results, we considered the respondents' cultural background and speculated about the potential influence of cultural teachings and elements in the selection of ways of coping with bereavement. Further, we compared the results obtained with those of the two other Swedish studies conducted among people coping with cancer and COVID-19 to further discuss the impact of culture on coping with illness, loss, grief, and crisis. The study supports the idea that culture plays an essential role in the choice of coping methods.", "doi": "10.3390/bs11100131", "pmid": "34677224", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bs11100131"}], "notes": [], "created": "2021-10-26T18:13:36.323Z", "modified": "2022-02-17T09:43:16.000Z"}, {"entity": "publication", "iuid": "b72a917223fa44d19c89cc86317f9892", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b72a917223fa44d19c89cc86317f9892.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b72a917223fa44d19c89cc86317f9892"}}, "title": "Identification of Unique Peptides for SARS-CoV-2 Diagnostics and Vaccine Development by an In Silico Proteomics Approach", "authors": [{"family": "Kesarwani", "given": "Veerbhan", "initials": "V"}, {"family": "Gupta", "given": "Rupal", "initials": "R"}, {"family": "Vetukuri", "given": "Ramesh Raju", "initials": "RR"}, {"family": "Kushwaha", "given": "Sandeep Kumar", "initials": "SK"}, {"family": "Gandhi", "given": "Sonu", "initials": "S"}], "type": "journal-article", "published": "2021-09-24", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "12", "issue": null, "pages": null}, "abstract": null, "doi": "10.3389/fimmu.2021.725240", "pmid": "34630400", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:50:30.496Z", "modified": "2021-11-29T06:11:19.925Z"}, {"entity": "publication", "iuid": "4ec7caedc3b24a29bc302f9d20e3bb70", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ec7caedc3b24a29bc302f9d20e3bb70.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ec7caedc3b24a29bc302f9d20e3bb70"}}, "title": "Power and sample size calculation for the win odds test: application to an ordinal endpoint in COVID-19 trials.", "authors": [{"family": "Gasparyan", "given": "Samvel B", "initials": "SB", "orcid": "0000-0002-4797-2208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7fe0aea6b8d940a4aa97beac64753452.json"}}, {"family": "Kowalewski", "given": "Elaine K", "initials": "EK", "orcid": "0000-0002-7915-877X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0c063ae9205470c9803add8044303bc.json"}}, {"family": "Folkvaljon", "given": "Folke", "initials": "F"}, {"family": "Bengtsson", "given": "Olof", "initials": "O"}, {"family": "Buenconsejo", "given": "Joan", "initials": "J", "orcid": "0000-0003-4514-2208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90cef2fa64d0486681f64332929d92cf.json"}}, {"family": "Adler", "given": "John", "initials": "J"}, {"family": "Koch", "given": "Gary G", "initials": "GG"}], "type": "journal article", "published": "2021-09-23", "journal": {"title": "J Biopharm Stat", "issn": "1520-5711", "pages": "1-23", "issn-l": null}, "abstract": "The win odds is a distribution-free method of comparing locations of distributions of two independent random variables. Introduced as a method for analyzing hierarchical composite endpoints, it is well suited to be used in the analysis of ordinal scale endpoints in COVID-19 clinical trials. For a single outcome, we provide power and sample size calculation formulas for the win odds test. We also provide an implementation of the win odds analysis method for a single ordinal outcome in a commonly used statistical software to make the win odds analysis fully reproducible.", "doi": "10.1080/10543406.2021.1968893", "pmid": "34551682", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-27T05:15:02.850Z", "modified": "2021-10-27T05:15:03.000Z"}, {"entity": "publication", "iuid": "7dc1fbdac9ae42de922320b7cfc08524", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7dc1fbdac9ae42de922320b7cfc08524.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7dc1fbdac9ae42de922320b7cfc08524"}}, "title": "Comparing Fear of COVID-19 and Preventive COVID-19 Infection Behaviors Between Iranian and Taiwanese Older People: Early Reaction May Be a Key", "authors": [{"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Liu", "given": "Chieh hsiu", "initials": "Ch"}, {"family": "Hou", "given": "Wen Li", "initials": "WL"}, {"family": "Chen", "given": "Yu Pin", "initials": "YP"}, {"family": "Li", "given": "Yueh Ping", "initials": "YP"}, {"family": "Kuo", "given": "Yi Jie", "initials": "YJ"}, {"family": "Lin", "given": "Chung Ying", "initials": "CY"}, {"family": "Scarf", "given": "Damian", "initials": "D"}], "type": "journal-article", "published": "2021-09-23", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2021.740333", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:49:06.339Z", "modified": "2021-10-11T17:49:06.356Z"}, {"entity": "publication", "iuid": "1b450365873f4738bbced961b479b7cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b450365873f4738bbced961b479b7cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b450365873f4738bbced961b479b7cc"}}, "title": "SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism.", "authors": [{"family": "Jing", "given": "Yukai", "initials": "Y"}, {"family": "Luo", "given": "Li", "initials": "L"}, {"family": "Chen", "given": "Ying", "initials": "Y"}, {"family": "Westerberg", "given": "Lisa S", "initials": "LS"}, {"family": "Zhou", "given": "Peng", "initials": "P", "orcid": "0000-0001-9863-4201", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8bf90702b7734b368503bc0926b23738.json"}}, {"family": "Xu", "given": "Zhiping", "initials": "Z"}, {"family": "Herrada", "given": "Andr\u00e9s A", "initials": "AA"}, {"family": "Park", "given": "Chan-Sik", "initials": "CS"}, {"family": "Kubo", "given": "Masato", "initials": "M"}, {"family": "Mei", "given": "Heng", "initials": "H"}, {"family": "Hu", "given": "Yu", "initials": "Y", "orcid": "0000-0002-2815-4568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0af90511a1494949bec5b0e595720c28.json"}}, {"family": "Lee", "given": "Pamela Pui-Wah", "initials": "PP"}, {"family": "Zheng", "given": "Bing", "initials": "B"}, {"family": "Sui", "given": "Zhiwei", "initials": "Z"}, {"family": "Xiao", "given": "Wei", "initials": "W"}, {"family": "Gong", "given": "Quan", "initials": "Q"}, {"family": "Lu", "given": "Zhongxin", "initials": "Z"}, {"family": "Liu", "given": "Chaohong", "initials": "C"}], "type": "journal article", "published": "2021-09-22", "journal": {"title": "Signal Transduct Target Ther", "issn": "2059-3635", "volume": "6", "issue": "1", "pages": "345", "issn-l": null}, "abstract": "The SARS-CoV-2 infection causes severe immune disruption. However, it is unclear if disrupted immune regulation still exists and pertains in recovered COVID-19 patients. In our study, we have characterized the immune phenotype of B cells from 15 recovered COVID-19 patients, and found that healthy controls and recovered patients had similar B-cell populations before and after BCR stimulation, but the frequencies of PBC in patients were significantly increased when compared to healthy controls before stimulation. However, the percentage of unswitched memory B cells was decreased in recovered patients but not changed in healthy controls upon BCR stimulation. Interestingly, we found that CD19 expression was significantly reduced in almost all the B-cell subsets in recovered patients. Moreover, the BCR signaling and early B-cell response were disrupted upon BCR stimulation. Mechanistically, we found that the reduced CD19 expression was caused by the dysregulation of cell metabolism. In conclusion, we found that SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism, which may provide a new intervention target to cure COVID-19.", "doi": "10.1038/s41392-021-00749-3", "pmid": "34552055", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41392-021-00749-3"}, {"db": "pmc", "key": "PMC8456405"}], "notes": [], "created": "2021-10-27T05:16:20.906Z", "modified": "2021-10-27T05:16:21.016Z"}, {"entity": "publication", "iuid": "dce6ed2b4e614c32b631d3857edb6053", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dce6ed2b4e614c32b631d3857edb6053.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dce6ed2b4e614c32b631d3857edb6053"}}, "title": "Making wise choices about low-value health care in the COVID-19 pandemic.", "authors": [{"family": "Clarke", "given": "Mike", "initials": "M"}, {"family": "Born", "given": "Karen", "initials": "K"}, {"family": "Johansson", "given": "Minna", "initials": "M"}, {"family": "J\u00f8rgensen", "given": "Karsten Juhl", "initials": "KJ"}, {"family": "Levinson", "given": "Wendy", "initials": "W"}, {"family": "Madrid", "given": "Eva", "initials": "E"}, {"family": "Meng", "given": "Dina Muscat", "initials": "DM"}, {"family": "Franco", "given": "Juan Victor Ariel", "initials": "JVA"}], "type": "editorial", "published": "2021-09-22", "journal": {"title": "Cochrane Database Syst Rev", "issn": "1469-493X", "volume": "9", "pages": "ED000153", "issn-l": null}, "abstract": null, "doi": "10.1002/14651858.ED000153", "pmid": "34549804", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-10-27T05:13:29.740Z", "modified": "2021-10-27T05:14:17.038Z"}, {"entity": "publication", "iuid": "69390533297940e28f31380bf9b161d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69390533297940e28f31380bf9b161d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69390533297940e28f31380bf9b161d9"}}, "title": "Do conspiracy theory and mistrust undermine people's intention to receive the COVID-19 vaccine in Austria?", "authors": [{"family": "Knobel", "given": "Phil", "initials": "P", "orcid": "0000-0003-2297-1193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bdf58f509c3e4e3b946fdd515d3cc9a8.json"}}, {"family": "Zhao", "given": "Xiang", "initials": "X", "orcid": "0000-0003-1054-9462", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad1f806684e54bc5986a15525c0a7c2d.json"}}, {"family": "White", "given": "Katherine M", "initials": "KM", "orcid": "0000-0002-0345-4724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e0eb1e8900e42c5ab75076f6b169218.json"}}], "type": "journal article", "published": "2021-09-22", "journal": {"title": "J Community Psychol", "issn": "1520-6629", "issn-l": null}, "abstract": "Conspiracy theories flourish during the coronavirus disease 2019 (COVID-19) pandemic especially regarding vaccinations. As the vaccination reluctancy in Austria is high, it is important to understand the antecedents of vaccination intention at the preapproval stage of the vaccination process. An online survey was conducted in August 2020 in Austria with 217 primarily younger, female, educated participants. A two-step cluster analysis resulted in a sceptics cluster with a clear antivaccination tendency along with a right-wing political position, lower trust in general vaccines and lower education levels and the reference cluster. A considerable percentage of participants reported their reluctancy to have a COVID-19 vaccine. Although vaccination intention can be explained by attitude and subjective norm, this decision-making process is undermined by underlying factors such as conspiracy ideation and political position. Policy makers and health interventionists should take political background into consideration in efforts to increase vaccine compliance.", "doi": "10.1002/jcop.22714", "pmid": "34551127", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-27T05:15:41.457Z", "modified": "2021-10-27T05:15:41.597Z"}, {"entity": "publication", "iuid": "b830017933024b4faf78792c42b2bb8a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b830017933024b4faf78792c42b2bb8a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b830017933024b4faf78792c42b2bb8a"}}, "title": "The Impact of COVID-19 on Sleep in Autistic Adults: Longitudinal Comparisons pre and During Lockdown.", "authors": [{"family": "Halstead", "given": "Elizabeth J", "initials": "EJ"}, {"family": "Sullivan", "given": "Emma C", "initials": "EC"}, {"family": "Dimitriou", "given": "Dagmara", "initials": "D"}], "type": "journal article", "published": "2021-09-21", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "708339", "issn-l": "1664-0640"}, "abstract": "Background: The longer-term impact of the pandemic on autistic adults' sleep are yet to be revealed, with studies concentrating on sleep in autistic children or mental health outcomes and coping strategies of autistic adults. Given the prevalence of sleep problems experienced by autistic adults and the changes in routine that have occurred as a result of COVID-19 societal restrictions, this study assessed the impact of the COVID-19 pandemic on sleep problems via a longitudinal subjective assessment method. Methods: Sleep data were gathered at three time points from 95 autistic adults, namely prior to the pandemic, at the start of COVID-19 and several months into COVID-19 to obtain a rich longitudinal dataset ascertaining how/if sleep patterns have changed in autistic adults over these several months. Results: In comparison to pre-lockdown, several sleep components were shown to improve during the lockdown. These improvements included reduced sleep latency (time taken to fall asleep), longer sleep duration, improved sleep efficiency, improved sleep quality, as well as improved daytime functioning. Pre-sleep cognitive arousal scores were found to decrease compared to pre-lockdown, meaning cognitive arousal improved. Approximately 65% of participants reported that they felt their sleep had been impacted since COVID-19 since Time 1, with the most common reasons reported as waking up exhausted (36.92%), not being able to get to sleep (33.85%), waking up in the night (29.23%), having a disrupted sleep pattern (27.69%), and nightmares (18.46%). Conclusions: Improvements in sleep may be related to societal changes (e.g., working from home) during the pandemic. Some of these changes are arguably beneficial for autistic adults in creating a more autism-inclusive society, for example telehealth opportunities for care. Further exploration of the associations between mental health and sleep are warranted.", "doi": "10.3389/fpsyt.2021.708339", "pmid": "34621194", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8490657"}], "notes": [], "created": "2021-10-10T15:08:30.601Z", "modified": "2021-10-10T15:08:30.611Z"}, {"entity": "publication", "iuid": "ef4b77c12ed44ed1a35fa7936352285c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef4b77c12ed44ed1a35fa7936352285c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef4b77c12ed44ed1a35fa7936352285c"}}, "title": "Priority Setting and Equity in COVID-19 Pandemic Plans: A Comparative Analysis of eighteen African Countries.", "authors": [{"family": "Kapiriri", "given": "Lydia", "initials": "L", "orcid": "0000-0002-1237-6369", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec392c3ae33d40f096e713eaa6a2be11.json"}}, {"family": "Kiwanuka", "given": "Suzanne", "initials": "S"}, {"family": "Biemba", "given": "Godfrey", "initials": "G"}, {"family": "Velez", "given": "Claudia", "initials": "C"}, {"family": "Razavi", "given": "S Donya", "initials": "SD"}, {"family": "Abelson", "given": "Julia", "initials": "J"}, {"family": "Essue", "given": "Beverly", "initials": "B"}, {"family": "Danis", "given": "Marion", "initials": "M"}, {"family": "Goold", "given": "Susan", "initials": "S"}, {"family": "Noorulhuda", "given": "Mariam", "initials": "M"}, {"family": "Nouvet", "given": "Elysee", "initials": "E"}, {"family": "Sandman", "given": "Lars", "initials": "L"}, {"family": "Williams", "given": "Ieystn", "initials": "I"}], "type": "journal article", "published": "2021-09-21", "journal": {"title": "Health Policy Plan", "issn": "1460-2237", "issn-l": null}, "abstract": "Priority setting represents an even bigger challenge during public health emergencies than routine times. This is because such emergencies compete with routine programs for the available health resources, strain health systems, and shift health care attention and resources towards containing the spread of the epidemic and treating those that fall seriously ill. This paper is part of a larger global study the aim of which is to evaluate the degree to which National COVID-19 preparedness and response plans incorporated priority setting concepts. IT and provides important insights into what and how priority decisions were made in a context of a pandemic. Specifically, with a focus on a sample of 18 African countries' pandemic plans, the paper aims to: (i) Explore the degree to which the documented priority setting processes adhere to established quality indicators of effective priority setting and (ii) To examine if there is a relationship between the number of quality indicators present in the pandemic plans and the country's economic context, health system and prior experiences with disease outbreaks. All the reviewed plans contained some aspects of expected priority setting processes but none of the national plans addressed all quality parameters. Most of the parameters were mentioned by less than 10 of the 18 country plans reviewed, and several plans identified one or two aspects of fair priority setting processes. Very few plans identified equity as a criterion for priority setting. Since the parameters are relevant to the quality of priority setting that is implemented during public health emergencies, and that most of the countries have pre-existing pandemic plans; it would be advisable that for the future (if not already happening) countries consider priority setting as a critical part of their routine health emergency and disease outbreak plans. Such an approach would ensure that priority setting is integral to pandemic planning, response, and recovery.", "doi": "10.1093/heapol/czab113", "pmid": "34545395", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6373138"}, {"db": "pmc", "key": "PMC8500007"}], "notes": [], "created": "2021-10-27T05:11:43.795Z", "modified": "2021-10-27T05:11:43.870Z"}, {"entity": "publication", "iuid": "610e095b5ab7410aaf936ca232bbc206", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/610e095b5ab7410aaf936ca232bbc206.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/610e095b5ab7410aaf936ca232bbc206"}}, "title": "Match-Fixing Causing Harm to Athletes on a COVID-19-Influenced Gambling Market: A Call for Research During the Pandemic and Beyond.", "authors": [{"family": "H\u00e5kansson", "given": "A", "initials": "A"}, {"family": "J\u00f6nsson", "given": "C", "initials": "C"}, {"family": "Kentt\u00e4", "given": "G", "initials": "G"}], "type": "journal article", "published": "2021-09-21", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "712300", "issn-l": "1664-1078"}, "abstract": "Match-fixing, although not a new problem, has received growing attention during the COVID-19 pandemic, which has been reported in the media to have increased the risk of match-fixing events. Gambling is a well-documented addictive behavior, and gambling-related fraud, match-fixing, is a challenge to the world of sports. Most research on match-fixing has a judicial or institutional perspective, and few studies focus on its individual consequences. Nevertheless, athletes may be at particular risk of mental health consequences from the exposure to or involvement in match-fixing. The COVID-19 crisis puts a spotlight on match-fixing, as the world of competitive sports shut down or changed substantially due to pandemic-related restrictions. We call for research addressing individual mental health and psycho-social correlates of match-fixing, and their integration into research addressing problem gambling, related to the pandemic and beyond.", "doi": "10.3389/fpsyg.2021.712300", "pmid": "34621216", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8490709"}], "notes": [], "created": "2021-10-10T15:08:15.461Z", "modified": "2021-10-10T15:08:15.471Z"}, {"entity": "publication", "iuid": "dfbabb7d946f4e988f6f3f48695c7edb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dfbabb7d946f4e988f6f3f48695c7edb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dfbabb7d946f4e988f6f3f48695c7edb"}}, "title": "Using informative features in machine learning based method for COVID-19 drug repurposing.", "authors": [{"family": "Aghdam", "given": "Rosa", "initials": "R", "orcid": "0000-0001-9045-9592", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/947e042b69f44191bb9aa48ca17314bb.json"}}, {"family": "Habibi", "given": "Mahnaz", "initials": "M"}, {"family": "Taheri", "given": "Golnaz", "initials": "G"}], "type": "journal article", "published": "2021-09-20", "journal": {"title": "J Cheminform", "issn": "1758-2946", "volume": "13", "issue": "1", "pages": "70", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) is caused by a novel virus named Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). This virus induced a large number of deaths and millions of confirmed cases worldwide, creating a serious danger to public health. However, there are no specific therapies or drugs available for COVID-19 treatment. While new drug discovery is a long process, repurposing available drugs for COVID-19 can help recognize treatments with known clinical profiles. Computational drug repurposing methods can reduce the cost, time, and risk of drug toxicity. In this work, we build a graph as a COVID-19 related biological network. This network is related to virus targets or their associated biological processes. We select essential proteins in the constructed biological network that lead to a major disruption in the network. Our method from these essential proteins chooses 93 proteins related to COVID-19 pathology. Then, we propose multiple informative features based on drug-target and protein-protein interaction information. Through these informative features, we find five appropriate clusters of drugs that contain some candidates as potential COVID-19 treatments. To evaluate our results, we provide statistical and clinical evidence for our candidate drugs. From our proposed candidate drugs, 80% of them were studied in other studies and clinical trials.", "doi": "10.1186/s13321-021-00553-9", "pmid": "34544500", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13321-021-00553-9"}, {"db": "pmc", "key": "PMC8451172"}], "notes": [], "created": "2021-10-10T15:37:29.486Z", "modified": "2021-11-19T10:49:54.346Z"}, {"entity": "publication", "iuid": "a245e60b78414c3b85feb1892b29e055", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a245e60b78414c3b85feb1892b29e055.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a245e60b78414c3b85feb1892b29e055"}}, "title": "The Association Between Financial Hardship and Mental Health Difficulties Among Adult Wage Earners During the COVID-19 Pandemic in Bangladesh: Findings From a Cross-Sectional Analysis.", "authors": [{"family": "Sultana", "given": "Mst Sadia", "initials": "MS"}, {"family": "Khan", "given": "Abid Hasan", "initials": "AH"}, {"family": "Hossain", "given": "Sahadat", "initials": "S"}, {"family": "Islam", "given": "Tauhidul", "initials": "T"}, {"family": "Hasan", "given": "M Tasdik", "initials": "MT"}, {"family": "Ahmed", "given": "Helal Uddin", "initials": "HU"}, {"family": "Li", "given": "Zezhi", "initials": "Z"}, {"family": "Khan", "given": "Jahangir A M", "initials": "JAM"}], "type": "journal article", "published": "2021-09-20", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "635884", "issn-l": "1664-0640"}, "abstract": "Background: The ongoing COVID-19 pandemic has created several challenges including financial burdens that may result in mental health conditions. This study was undertaken to gauge mental health difficulties during the COVID-19 pandemic and gain an insight into wage earners' mental health. Method: This cross-sectional study was conducted through an online survey. A t total of 707 individual Bangladeshi wage earners were enrolled between 20 and 30 May 2020. The questionnaire had sections on sociodemographic information, COVID-19 related questions, PHQ-9 and GAD-7 scales. STATA version 14.1 program was used to carry out all the analyses. Results: The study revealed that 58.6 and 55.9% of the respondents had moderate to severe anxiety and depressive symptoms, respectively. The total monthly income was <30,000 BDT (353.73USD) and displayed increased odds of suffering from depressive symptoms (OR = 4.12; 95% CI: 2.68-6.34) and anxiety (OR = 3.31; 95% CI: 2.17-5.03). Participants who did not receive salary income, had no income source during the pandemic, had financial problems, and inadequate food supply and were more likely to suffer from anxiety and depressive symptoms (p \u2264 0.01). Perceiving the upcoming financial crisis as a stressor was a potential risk factor for anxiety (OR = 1.91; 95% CI:1.32-2.77) and depressive symptoms (OR = 1.50; 95% CI:1.04-2.16). Limitations: The online survey method used in this study limits the generalizability of the findings and self-reported answers might include selection and social desirability bias as a community-based survey was not possible during the pandemic. Conclusion: Wage earners in a low resource setting like Bangladesh require mental health attention and financial consideration to deal with mental health difficulties.", "doi": "10.3389/fpsyt.2021.635884", "pmid": "34616314", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8488168"}], "notes": [], "created": "2021-10-10T15:25:30.166Z", "modified": "2021-10-10T15:25:30.177Z"}, {"entity": "publication", "iuid": "7b93bc8d2d3443a98a676c5352936599", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b93bc8d2d3443a98a676c5352936599.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b93bc8d2d3443a98a676c5352936599"}}, "title": "Sickness Presenteeism Among the Swedish Self-Employed During the Covid-19 Pandemic.", "authors": [{"family": "Vinberg", "given": "Stig", "initials": "S"}, {"family": "Landstad", "given": "Bodil J", "initials": "BJ"}, {"family": "Tjulin", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Nordenmark", "given": "Mikael", "initials": "M"}], "type": "journal article", "published": "2021-09-20", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "723036", "issn-l": "1664-1078"}, "abstract": "The present study analyzed the impact of business operations, work and family circumstances, and well-being on the risk of sickness presenteeism for Swedish self-employed workers during the Covid-19 pandemic. It is of great importance to investigate the impact of the pandemic on the self-employed and their enterprises because they are seen as key drivers of economic growth and constitute an expanding group in many countries. Data were obtained from 845 self-employed workers by a web-based survey including questions about background information, work and family circumstances, well-being, sickness presenteeism, and questions about the pandemic. Results were that around 40% of the self-employed introduced new products, processes, and marketing methods, and just over 50% attempted to get new customers during the pandemic. Nearly half of the self-employed people reported that they lost contracts, and 22% judged the risk of bankruptcy to be quite or highly likely. Regression analyses showed that the more the self-employed reported impact on business indicators, increased work hours, a higher level of work-family conflict, and a lower level of mental well-being, the higher the risk of sickness presenteeism. The most common reasons given by the participants for sickness presenteeism during the pandemic were \"nobody else can carry out my responsibilities,\" \"I can't afford to take sick leave\" and \"I enjoy my work.\" Conclusions are that a critical event such as the pandemic probably adds to an already high workload for the self-employed. Impact on business operations such as developing new products/services and marketing, risk of bankruptcy and increased work hours seems to be important factors for explaining sickness presenteeism among the self-employed. Theoretical contributions from the study suggest that critical events such as the Covid-19 pandemic should be considered as an important environmental factor when studying sickness presenteeism among self-employed.", "doi": "10.3389/fpsyg.2021.723036", "pmid": "34621220", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8490737"}], "notes": [], "created": "2021-10-10T15:07:50.898Z", "modified": "2021-10-10T15:07:50.911Z"}, {"entity": "publication", "iuid": "1c094d4be4214666a0f2dbbfc37eb5cd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1c094d4be4214666a0f2dbbfc37eb5cd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1c094d4be4214666a0f2dbbfc37eb5cd"}}, "title": "Risk-Assessment of Hospitalized Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infected Patients Using Laboratory Data and Immune Cell Morphological Assessment.", "authors": [{"family": "Kubik", "given": "Thane", "initials": "T"}, {"family": "Hou", "given": "Mary", "initials": "M"}, {"family": "Traverse", "given": "Tammie", "initials": "T"}, {"family": "Lareau", "given": "Mireille", "initials": "M"}, {"family": "Jenei", "given": "Veronika", "initials": "V"}, {"family": "Oberding", "given": "Lisa", "initials": "L"}, {"family": "Pillai", "given": "Dylan R", "initials": "DR"}, {"family": "Gillrie", "given": "Mark", "initials": "M"}, {"family": "Suryanarayan", "given": "Deepa", "initials": "D"}, {"family": "Sidhu", "given": "Davinder Singh", "initials": "DS"}, {"family": "Vergara-Lluri", "given": "Maria", "initials": "M"}, {"family": "Nakashima", "given": "Megan O", "initials": "MO"}, {"family": "Mahe", "given": "Etienne", "initials": "E"}], "type": "journal article", "published": "2021-09-20", "journal": {"title": "Arch Pathol Lab Med", "issn": "1543-2165", "issn-l": null}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious agent, with the propensity to cause severe illness. While vaccine uptake has been increasing in recent months, many regions remain at risk of significant coronavirus disease 19 (COVID-19) related healthcare burden. Health systems will continue to benefit from the availability of a variety of clinical and laboratory model when other triaging models are equivocal.\n\nTo validate previously reported clinical laboratory abnormalities seen in COVID-19 patients and identify what laboratory parameters might be outcome-predictive.\n\nWe undertook an observational study of hospital-admitted COVID-19 patients (n=113), looking at a broad selection of clinical, laboratory, peripheral blood smear, and outcome data over discrete discovery and validation periods from March 2020 to November 2020.\n\nWe confirmed the findings of previous studies noting derangement of a variety of laboratory parameters in COVID-19 patients, including peripheral blood morphological changes. We also devised a simple-to-use decision tree by which patients could be risk stratified on the basis of Red Blood Cell count, creatinine, urea, and atypical plasmacytoid lymphocyte (\"covidocyte\") count. This outcome classifier performed comparably to the World Health Organization clinical classifier and the neutrophil-lymphocyte ratio.\n\nOur data add to the increasing number of studies cataloguing laboratory changes in COVID-19, and support the clinical utility of incorporating blood morphological assessment in the workup of hospitalized COVID-19 patients.", "doi": "10.5858/arpa.2021-0368-SA", "pmid": "34543379", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "470568"}], "notes": [], "created": "2021-10-10T15:35:57.917Z", "modified": "2021-10-10T15:35:57.929Z"}, {"entity": "publication", "iuid": "a95016e0838f4ca0ba303faaf486166e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a95016e0838f4ca0ba303faaf486166e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a95016e0838f4ca0ba303faaf486166e"}}, "title": "Factors affecting Pakistani young adults' intentions to uptake COVID-19 vaccination: An extension of the theory of planned behavior.", "authors": [{"family": "Ullah", "given": "Irfan", "initials": "I", "orcid": "0000-0003-1100-101X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8d5a7e15ae6487cbdda0de3b2a531c3.json"}}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Malik", "given": "Najma Iqbal", "initials": "NI", "orcid": "0000-0002-3521-1014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c17242b513143b18e3bb8108f009ca4.json"}}, {"family": "Wu", "given": "Tzu-Yi", "initials": "TY"}, {"family": "Araban", "given": "Marzieh", "initials": "M", "orcid": "0000-0001-9920-0261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/267b131c24034c33b0ddff1b97f316a5.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-09-20", "journal": {"title": "Brain Behav", "issn": "2162-3279", "pages": "e2370", "issn-l": null}, "abstract": "Aside from personal beliefs, young adults' intention to uptake the COVID-19 vaccine can be influenced by their fear of COVID-19 and perceived infectability of COVID-19. The present study incorporated fear of COVID-19 and perceived infectability with the theory of planned behavior (TPB) to form an expanded TPB to analyze factors affecting Pakistani young adults' intentions to uptake the COVID-vaccine in Pakistan.\n\nA cross-sectional study was conducted and recruited participants from Pakistani social media users. The proposed extended TPB model was examined by using structural equation modeling.\n\nA total of 1034 individuals replied to the survey. The three factors of the original theory of planned behavior and the fear of COVID-19 were positively related to their intention to uptake COVID-19 vaccination (r = 0.25-0.66). Moreover, the perceived infectability positively influenced the three theories of planned behavioral factors and the fear of COVID-19 (r = 0.27-0.60), also affecting the participants' intentions to uptake COVID-19 vaccination.\n\nPerceived infectability was positively related to the participants' intentions to uptake COVID-19 vaccination, and perceived behavioral control was the strongest mediator. More evidence-based information concerning treatments and COVID-19 vaccination are needed to encourage individuals to uptake the vaccine.", "doi": "10.1002/brb3.2370", "pmid": "34543522", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:36:16.800Z", "modified": "2021-11-18T14:28:01.679Z"}, {"entity": "publication", "iuid": "26f7a8f9b07448189123efea423b99df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26f7a8f9b07448189123efea423b99df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26f7a8f9b07448189123efea423b99df"}}, "title": "Civil-Military Collaboration to Facilitate Rapid Deployment of a Mobile Laboratory in Early Response to COVID-19: A High-Readiness Exercise.", "authors": [{"family": "Bacchus", "given": "Philip", "initials": "P"}, {"family": "Nissen", "given": "Karolina", "initials": "K"}, {"family": "Berg", "given": "Johanna", "initials": "J"}, {"family": "Br\u00e5ve", "given": "Andreas", "initials": "A"}, {"family": "Gyll", "given": "Jenny", "initials": "J"}, {"family": "Larsson", "given": "Christer", "initials": "C"}, {"family": "Muradrasoli", "given": "Shaman", "initials": "S"}, {"family": "Tellstr\u00f6m", "given": "Andreas", "initials": "A"}, {"family": "Salaneck", "given": "Erik", "initials": "E"}], "type": "journal article", "published": "2021-09-20", "journal": {"title": "Health Secur", "issn": "2326-5108", "volume": "19", "issue": "5", "pages": "488-497", "issn-l": null}, "abstract": "Rapid and adaptable diagnostic capabilities are of great importance in the face of emerging infectious diseases. In an outbreak, timely establishment of diagnostic routines is crucial to identifying cases and preventing the spread of the disease, especially when faced with high-consequence pathogens. In this article, we describe a multiagency exercise including the rapid deployment and diagnostic adaptation of the Swedish Armed Forces mobile laboratory (biological field analysis laboratory) in the context of COVID-19. This deployment was initiated as a high-readiness exercise at the end of January 2020, when the global development of the outbreak was still uncertain. Through collaboration with the Public Health Agency of Sweden and a civilian hospital, a real-time reverse transcriptase polymerase chain reaction method specific to SARS-CoV-2 was made available and adapted to the mobile laboratory, and the team established and evaluated a functional and efficient diagnostic asset along with a logistical support chain. We also organized and evaluated mobile testing teams, and the method was later used in large-scale, national, cross-sectional COVID-19 surveys in several regions of Sweden. In this article, we focus on the challenges of overbridging the civil-military interface in this context and identifying lessons learned and added values to the response during the early pandemic. We propose that the experiences from this exercise and governmental agency collaboration are valuable in preparation for future outbreaks.", "doi": "10.1089/hs.2021.0011", "pmid": "34542343", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:35:34.328Z", "modified": "2021-11-18T14:21:28.133Z"}, {"entity": "publication", "iuid": "5d7ab7aa2e3f45998eec2af19db5271f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d7ab7aa2e3f45998eec2af19db5271f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d7ab7aa2e3f45998eec2af19db5271f"}}, "title": "Declining mortality of cerebral venous sinus thrombosis with thrombocytopenia after SARS-CoV-2 vaccination.", "authors": [{"family": "van de Munckhof", "given": "Anita", "initials": "A"}, {"family": "Krzywicka", "given": "Katarzyna", "initials": "K"}, {"family": "Aguiar de Sousa", "given": "Diana", "initials": "D", "orcid": "0000-0002-6702-7924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cc3515119a247859fe1fea025f703ef.json"}}, {"family": "S\u00e1nchez van Kammen", "given": "Mayte", "initials": "M"}, {"family": "Heldner", "given": "Mirjam R", "initials": "MR", "orcid": "0000-0002-3594-2159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8280f8c6ea3a486abae8acc6aa491985.json"}}, {"family": "Jood", "given": "Katarina", "initials": "K"}, {"family": "Lindgren", "given": "Erik", "initials": "E", "orcid": "0000-0002-7628-5044", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0e973b3c74ff4e5cba42da605a13bc61.json"}}, {"family": "Tatlisumak", "given": "Turgut", "initials": "T"}, {"family": "Putaala", "given": "Jukka", "initials": "J"}, {"family": "Kremer Hovinga", "given": "Johanna A", "initials": "JA"}, {"family": "Middeldorp", "given": "Saskia", "initials": "S"}, {"family": "Levi", "given": "Marcel", "initials": "M"}, {"family": "Arnold", "given": "Marcel", "initials": "M"}, {"family": "Ferro", "given": "Jos\u00e9 M", "initials": "JM"}, {"family": "Coutinho", "given": "Jonathan M", "initials": "JM", "orcid": "0000-0002-8284-982X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98cadafdcc044688bab25a3d7f9562b9.json"}}], "type": "journal article", "published": "2021-09-18", "journal": {"title": "Eur J Neurol", "issn": "1468-1331", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "High mortality rates have been reported in patients with cerebral venous sinus thrombosis (CVST) due to vaccine-induced immune thrombotic thrombocytopenia (VITT) after vaccination with adenoviral vector SARS-CoV-2 vaccines. The aim of this study was to evaluate whether mortality of patients with CVST-VITT has decreased over time.\r\n\r\nWe used the EudraVigilance database of the European Medicines Agency to identify cases of CVST with concomitant thrombocytopenia occurring within 28 days of SARS-CoV-2 vaccination. Vaccines were grouped based on vaccine type (adenoviral or mRNA). Cases with CVST onset until 28 March were compared to cases after 28 March 2021, which was the day when the first scientific paper on VITT was published.\r\n\r\nWe identified 270 cases of CVST with thrombocytopenia, of which 266 (99%) occurred after adenoviral vector SARS-CoV-2 vaccination (ChAdOx1 nCoV-19 n=243, Ad26.COV2.S n=23). Reported mortality among adenoviral cases with onset up to 28 March 2021 was 47/99 (47%, 95%CI 37-58%) compared to 36/167 (22%, 95%CI 16-29%) in cases with onset after 28 March (p=<0.001). None of the 4 cases of CVST with thrombocytopenia occurring after mRNA vaccination died.\r\n\r\nReported mortality of CVST with thrombocytopenia after vaccination with adenoviral vector-based SARS-CoV-2 vaccines has significantly decreased over time, which may indicate a beneficial effect of earlier recognition and/or improved treatment on outcome after VITT.", "doi": "10.1111/ene.15113", "pmid": "34536256", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-09-20T16:56:40.912Z", "modified": "2021-12-07T15:26:05.448Z"}, {"entity": "publication", "iuid": "89ad16f8a9aa42e793d7f2ed72e2371c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/89ad16f8a9aa42e793d7f2ed72e2371c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/89ad16f8a9aa42e793d7f2ed72e2371c"}}, "title": "Monthlong Intubated Patient with Life-Threatening COVID-19 and Cerebral Microbleeds Suffers Only Mild Cognitive Sequelae at 8-Month Follow-up: A Case Report.", "authors": [{"family": "Backman", "given": "Linda", "initials": "L"}, {"family": "M\u00f6ller", "given": "Marika C", "initials": "MC"}, {"family": "Thelin", "given": "Eric P", "initials": "EP"}, {"family": "Dahlgren", "given": "Daniel", "initials": "D"}, {"family": "Deboussard", "given": "Catharina", "initials": "C"}, {"family": "\u00d6stlund", "given": "Gunilla", "initials": "G"}, {"family": "Lindau", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-09-17", "journal": {"title": "Arch Clin Neuropsychol", "issn": "1873-5843", "issn-l": null}, "abstract": "To elaborate on possible cognitive sequelae related to COVID-19, associated cerebrovascular injuries as well as the general consequences from intensive care. COVID-19 is known to have several, serious CNS-related consequences, but neuropsychological studies of severe COVID-19 are still rare.\n\nM., a 45-year-old man, who survived a severe COVID-19 disease course including Acute Respiratory Distress Syndrome (ARDS), cerebral microbleeds, and 35 days of mechanical ventilation, is described. We elaborate on M's recovery and rehabilitation process from onset to the 8-month follow-up. The cognitive functions were evaluated with a comprehensive screening battery at 4 weeks after extubation and at the 8-month follow-up.\n\nFollowing extubation, M. was delirious, reported visual hallucinations, and had severe sleeping difficulties. At about 3 months after COVID-19 onset, M. showed mild to moderate deficits on tests measuring processing speed, working memory, and attention. At assessments at 8 months, M. performed better, with results above average on tests measuring learning, memory, word fluency, and visuospatial functions. Minor deficits were still found regarding logical reasoning, attention, executive functioning, and processing speed. There were no lingering psychiatric symptoms. While M. had returned to a part-time job, he was not able to resume previous work-tasks.\n\nThis case-study demonstrates possible cognitive deficits after severe COVID-19 and emphasizes the need of a neuropsychological follow-up, with tests sensitive to minor deficits. The main findings of this report provide some support that the long-term prognosis for cognition in severe COVID-19 may be hopeful.", "doi": "10.1093/arclin/acab075", "pmid": "34530432", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6371352"}], "notes": [], "created": "2021-09-20T16:53:26.335Z", "modified": "2021-09-20T16:53:37.245Z"}, {"entity": "publication", "iuid": "8e5828a256014e558fdb864e18dd43d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e5828a256014e558fdb864e18dd43d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e5828a256014e558fdb864e18dd43d4"}}, "title": "Heart failure in COVID-19: the multicentre, multinational PCHF-COVICAV registry.", "authors": [{"family": "Sokolski", "given": "Mateusz", "initials": "M", "orcid": "0000-0001-9925-3566", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19276192c9dd4c47b35f4877b039b729.json"}}, {"family": "Trenson", "given": "Sander", "initials": "S", "orcid": "0000-0002-3902-0047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de369e2bc9d24a359ff118e2c1c7c79c.json"}}, {"family": "Sokolska", "given": "Justyna M", "initials": "JM", "orcid": "0000-0002-4759-5879", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8169d90790945999f1701f0f1e6ae26.json"}}, {"family": "D'Amario", "given": "Domenico", "initials": "D"}, {"family": "Meyer", "given": "Philippe", "initials": "P"}, {"family": "Poku", "given": "Nana K", "initials": "NK"}, {"family": "Biering-S\u00f8rensen", "given": "Tor", "initials": "T"}, {"family": "H\u00f8jbjerg Lassen", "given": "Mats C", "initials": "MC"}, {"family": "Skaarup", "given": "Kristoffer G", "initials": "KG"}, {"family": "Barge-Caballero", "given": "Eduardo", "initials": "E"}, {"family": "Pouleur", "given": "Anne-Catherine", "initials": "AC"}, {"family": "Stolfo", "given": "Davide", "initials": "D"}, {"family": "Sinagra", "given": "Gianfranco", "initials": "G"}, {"family": "Ablasser", "given": "Klemens", "initials": "K"}, {"family": "Muster", "given": "Viktoria", "initials": "V"}, {"family": "Rainer", "given": "Peter P", "initials": "PP"}, {"family": "Wallner", "given": "Markus", "initials": "M"}, {"family": "Chiodini", "given": "Alessandra", "initials": "A"}, {"family": "Heiniger", "given": "Pascal S", "initials": "PS"}, {"family": "Mikulicic", "given": "Fran", "initials": "F"}, {"family": "Schwaiger", "given": "Judith", "initials": "J"}, {"family": "Winnik", "given": "Stephan", "initials": "S"}, {"family": "Cakmak", "given": "Huseyin A", "initials": "HA"}, {"family": "Gaudenzi", "given": "Margherita", "initials": "M"}, {"family": "Mapelli", "given": "Massimo", "initials": "M"}, {"family": "Mattavelli", "given": "Irene", "initials": "I"}, {"family": "Paul", "given": "Matthias", "initials": "M"}, {"family": "Cabac-Pogorevici", "given": "Irina", "initials": "I"}, {"family": "Bouleti", "given": "Claire", "initials": "C"}, {"family": "Lilliu", "given": "Marzia", "initials": "M"}, {"family": "Minoia", "given": "Chiara", "initials": "C"}, {"family": "Dauw", "given": "Jeroen", "initials": "J"}, {"family": "Costa", "given": "J\u00e9r\u00f4me", "initials": "J"}, {"family": "Celik", "given": "Ahmet", "initials": "A"}, {"family": "Mewton", "given": "Nathan", "initials": "N"}, {"family": "Montenegro", "given": "Carlos E L", "initials": "CEL"}, {"family": "Matsue", "given": "Yuya", "initials": "Y"}, {"family": "Loncar", "given": "Goran", "initials": "G"}, {"family": "Marchel", "given": "Michal", "initials": "M"}, {"family": "Bechlioulis", "given": "Aris", "initials": "A"}, {"family": "Michalis", "given": "Lampros", "initials": "L"}, {"family": "D\u00f6rr", "given": "Marcus", "initials": "M"}, {"family": "Prihadi", "given": "Edgard", "initials": "E"}, {"family": "Schoenrath", "given": "Felix", "initials": "F"}, {"family": "Messroghli", "given": "Daniel R", "initials": "DR"}, {"family": "Mullens", "given": "Wilfried", "initials": "W"}, {"family": "Lund", "given": "Lars H", "initials": "LH"}, {"family": "Rosano", "given": "Giuseppe M C", "initials": "GMC", "orcid": "0000-0002-6868-4248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9db1f3658c8746599ddc172e6604c5b4.json"}}, {"family": "Ponikowski", "given": "Piotr", "initials": "P", "orcid": "0000-0002-3391-7064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9e5fe099039493dbc18fbfd549d4077.json"}}, {"family": "Ruschitzka", "given": "Frank", "initials": "F", "orcid": "0000-0001-5972-0596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/681536426df648299efac9c2e568ad13.json"}}, {"family": "Flammer", "given": "Andreas J", "initials": "AJ", "orcid": "0000-0002-1373-0630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/efbe793c83aa487ba4d0d6b021276670.json"}}], "type": "journal article", "published": "2021-09-17", "journal": {"title": "ESC Heart Fail", "issn": "2055-5822", "issn-l": null}, "abstract": "We assessed the outcome of hospitalized coronavirus disease 2019 (COVID-19) patients with heart failure (HF) compared with patients with other cardiovascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia). We further wanted to determine the incidence of HF events and its consequences in these patient populations.\n\nInternational retrospective Postgraduate Course in Heart Failure registry for patients hospitalized with COVID-19 and CArdioVascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia) was performed in 28 centres from 15 countries (PCHF-COVICAV). The primary endpoint was in-hospital mortality. Of 1974 patients hospitalized with COVID-19, 1282 had cardiovascular disease and/or risk factors (median age: 72 [interquartile range: 62-81] years, 58% male), with HF being present in 256 [20%] patients. Overall in-hospital mortality was 25% (n = 323/1282 deaths). In-hospital mortality was higher in patients with a history of HF (36%, n = 92) compared with non-HF patients (23%, n = 231, odds ratio [OR] 1.93 [95% confidence interval: 1.44-2.59], P < 0.001). After adjusting, HF remained associated with in-hospital mortality (OR 1.45 [95% confidence interval: 1.01-2.06], P = 0.041). Importantly, 186 of 1282 [15%] patients had an acute HF event during hospitalization (76 [40%] with de novo HF), which was associated with higher in-hospital mortality (89 [48%] vs. 220 [23%]) than in patients without HF event (OR 3.10 [2.24-4.29], P < 0.001).\n\nHospitalized COVID-19 patients with HF are at increased risk for in-hospital death. In-hospital worsening of HF or acute HF de novo are common and associated with a further increase in in-hospital mortality.", "doi": "10.1002/ehf2.13549", "pmid": "34533287", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-09-20T16:55:47.088Z", "modified": "2021-09-20T16:56:00.074Z"}, {"entity": "publication", "iuid": "dd02639389794c4c97fa776727dbcdb9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dd02639389794c4c97fa776727dbcdb9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dd02639389794c4c97fa776727dbcdb9"}}, "title": "Neurological manifestations of COVID-19: A comprehensive literature review and discussion of mechanisms.", "authors": [{"family": "Johansson", "given": "Anton", "initials": "A"}, {"family": "Mohamed", "given": "Mohamed S", "initials": "MS"}, {"family": "Moulin", "given": "Thiago C", "initials": "TC"}, {"family": "Schi\u00f6th", "given": "Helgi B", "initials": "HB"}], "type": "journal article", "published": "2021-09-15", "journal": {"title": "J Neuroimmunol", "issn": "1872-8421", "volume": "358", "pages": "577658", "issn-l": null}, "abstract": "Several neurological symptoms and complications have been described in association with COVID-19, such as anosmia, ageusia, encephalitis and Guillain-Barr\u00e9 syndrome. Here, we review the literature describing SARS-CoV-2-induced neurological manifestations and provide a comprehensive discussion of proposed mechanisms underlying the neurological pathophysiology. First, we analyse the neuroinvasiveness potential of the coronavirus family based on previous SARS-CoV-1 studies. Then, we describe the current evidence on COVID-19-induced nervous tissue damage, including processes behind brain vasculopathy and cytokine storm. We also discuss in detail anosmia and Guillain-Barr\u00e9 syndrome. Finally, we provide a summarised timeline of the main findings in the field. Future perspectives are presented, and suggestions of further investigations to clarify how SARS-COV-2 can affect the CNS.", "doi": "10.1016/j.jneuroim.2021.577658", "pmid": "34304141", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8272134"}, {"db": "pii", "key": "S0165-5728(21)00185-5"}], "notes": [], "created": "2021-08-05T07:03:24.380Z", "modified": "2023-01-13T13:24:48.655Z"}, {"entity": "publication", "iuid": "cdb5c73e050b4848a26ea799d4720749", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cdb5c73e050b4848a26ea799d4720749.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cdb5c73e050b4848a26ea799d4720749"}}, "title": "Internet addiction and psychological distress among Chinese schoolchildren before and during the COVID-19 outbreak: A latent class analysis.", "authors": [{"family": "Chen", "given": "I-Hua", "initials": "I"}, {"family": "Chen", "given": "Chao-Ying", "initials": "C"}, {"family": "Liu", "given": "Chieh-Hsiu", "initials": "C"}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Chen", "given": "Yu-Pin", "initials": "Y"}, {"family": "Kuo", "given": "Yi-Jie", "initials": "Y"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Wang", "given": "Shu-Mei", "initials": "S"}], "type": "journal article", "published": "2021-09-15", "journal": {"title": "J Behav Addict", "issn": "2063-5303", "issn-l": null, "volume": "10", "issue": "3", "pages": "731-746"}, "abstract": "The present longitudinal study examined the changes in problematic internet use (problematic smartphone use, problematic social media use, and problematic gaming) and changes in COVID-19-related psychological distress (fear of COVID-19 and worry concerning COVID-19) across three time-points (before the COVID-19 outbreak, during the initial stages of the COVID-19 outbreak, and during the COVID-19 outbreak recovery period).\r\n\r\nA total of 504 Chinese schoolchildren completed measures concerning problematic internet use and psychological distress across three time-points. Latent class analysis (LCA) was used to classify participants into three groups of problematic internet use comprising Group 1 (lowest level), Group 2 (moderate level), and Group 3 (highest level).\r\n\r\nStatistical analyses showed that as problematic use of internet-related activities declined among Group 3 participants across the three time points, participants in Group 1 and Group 2 had increased problematic use of internet-related activities. Although there was no between-group difference in relation to worrying concerning COVID-19 infection, Groups 2 and 3 had significantly higher levels of fear of COVID-19 than Group 1 during the COVID-19 recovery period. Regression analysis showed that change in problematic internet use predicted fear of COVID-19 during the recovery period.\r\n\r\nThe varied levels of problematic internet use among schoolchildren reflect different changing trends of additive behaviors during COVID-19 outbreak and recovery periods.", "doi": "10.1556/2006.2021.00052", "pmid": "34529588", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-09-20T16:52:00.538Z", "modified": "2021-11-18T14:20:35.797Z"}, {"entity": "publication", "iuid": "a404c0efa6384c3b9e7bcc42befc5f5a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a404c0efa6384c3b9e7bcc42befc5f5a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a404c0efa6384c3b9e7bcc42befc5f5a"}}, "title": "A Public Health Research Agenda for Managing Infodemics: Methods and Results of the First WHO Infodemiology Conference.", "authors": [{"family": "Calleja", "given": "Neville", "initials": "N", "orcid": "0000-0003-1800-2103", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b1ec37c898746abb5adc2a199f1ecf7.json"}}, {"family": "AbdAllah", "given": "AbdelHalim", "initials": "A", "orcid": "0000-0002-3441-9219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d660b25c91547e58020fb1aaad3f931.json"}}, {"family": "Abad", "given": "Neetu", "initials": "N", "orcid": "0000-0001-6999-4494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70cf4e5207a6403493e3490748c873ac.json"}}, {"family": "Ahmed", "given": "Naglaa", "initials": "N", "orcid": "0000-0003-3255-3948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e330ae7279149a9a88919e762a7d266.json"}}, {"family": "Albarracin", "given": "Dolores", "initials": "D", "orcid": "0000-0002-9575-1637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/54e3e6521de74104ae67ec4abbe5b9da.json"}}, {"family": "Altieri", "given": "Elena", "initials": "E", "orcid": "0000-0001-6603-3399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a71adae43bdb435d9a282a876d7e33a7.json"}}, {"family": "Anoko", "given": "Julienne N", "initials": "JN", "orcid": "0000-0002-5436-311X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a355367e6c34aac9627c54c755c0005.json"}}, {"family": "Arcos", "given": "Ruben", "initials": "R", "orcid": "0000-0002-9665-5874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5f8621e19e94647b28a1ba01330da9d.json"}}, {"family": "Azlan", "given": "Arina Anis", "initials": "AA", "orcid": "0000-0001-5484-1188", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2510a9cda05d4bcf93be48fd0ed13525.json"}}, {"family": "Bayer", "given": "Judit", "initials": "J", "orcid": "0000-0003-0558-807X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7637e48fa0440a8b7e44d080339d552.json"}}, {"family": "Bechmann", "given": "Anja", "initials": "A", "orcid": "0000-0002-5588-5155", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d144b5ff2fa74ce9ba8a5b01ecfd0f9f.json"}}, {"family": "Bezbaruah", "given": "Supriya", "initials": "S", "orcid": "0000-0002-4064-1297", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5601786cb9ce4e6fa0d71a5c493621ed.json"}}, {"family": "Briand", "given": "Sylvie C", "initials": "SC", "orcid": "0000-0001-6929-5335", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51ec51b7d86249469922ee9bf2b25c63.json"}}, {"family": "Brooks", "given": "Ian", "initials": "I", "orcid": "0000-0002-3793-3635", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bb0c9e7af664aff9ae71eb5d11a1872.json"}}, 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"Trewinnard", "given": "Tom", "initials": "T", "orcid": "0000-0001-7457-1322", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/360ee67acf5d4c31a8a2873c959bdac5.json"}}, {"family": "Turner", "given": "Shannon", "initials": "S", "orcid": "0000-0001-7425-3607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1df1ce4911eb47c9b4e0dbb4d7b8d058.json"}}, {"family": "Tworek", "given": "Heidi", "initials": "H", "orcid": "0000-0001-8825-7895", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b2de2bd58fc4c61b1b452d99c58d437.json"}}, {"family": "Uakkas", "given": "Saad", "initials": "S", "orcid": "0000-0001-6850-9901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9fbb96caef9a4c06831fa53fe57551bb.json"}}, {"family": "Vraga", "given": "Emily", "initials": "E", "orcid": "0000-0002-3016-3869", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb4c3fa0e0724326bdce31886a98011f.json"}}, {"family": "Wardle", "given": "Claire", "initials": "C", "orcid": "0000-0003-4597-8574", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72fd5fef1e8d4936ad46dbfba4004150.json"}}, {"family": "Wasserman", "given": "Herman", "initials": "H", "orcid": "0000-0002-2553-1989", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e43d8563aabc4fdb9dd23f5061226687.json"}}, {"family": "Wilhelm", "given": "Elisabeth", "initials": "E", "orcid": "0000-0002-4641-516X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd5af5af0a8348259121ef1a07fd5d61.json"}}, {"family": "W\u00fcrz", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3371-2736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4f15dda255248aea3ad25bbd7e6f035.json"}}, {"family": "Yau", "given": "Brian", "initials": "B", "orcid": "0000-0003-4255-9243", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2178627e893c4a6a877dbbd168aa441b.json"}}, {"family": "Zhou", "given": "Lei", "initials": "L", "orcid": "0000-0002-6640-0774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98aff1a8ad36481c88971dcdc2cefcb8.json"}}, {"family": "Purnat", "given": "Tina D", "initials": "TD", "orcid": "0000-0002-0257-6631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a36f3dacd5946868c9e0ed41002c266.json"}}], "type": "journal article", "published": "2021-09-15", "journal": {"title": "JMIR Infodemiology", "issn": "2564-1891", "volume": "1", "issue": "1", "pages": "e30979", "issn-l": null}, "abstract": "An infodemic is an overflow of information of varying quality that surges across digital and physical environments during an acute public health event. It leads to confusion, risk-taking, and behaviors that can harm health and lead to erosion of trust in health authorities and public health responses. Owing to the global scale and high stakes of the health emergency, responding to the infodemic related to the pandemic is particularly urgent. Building on diverse research disciplines and expanding the discipline of infodemiology, more evidence-based interventions are needed to design infodemic management interventions and tools and implement them by health emergency responders.\n\nThe World Health Organization organized the first global infodemiology conference, entirely online, during June and July 2020, with a follow-up process from August to October 2020, to review current multidisciplinary evidence, interventions, and practices that can be applied to the COVID-19 infodemic response. This resulted in the creation of a public health research agenda for managing infodemics.\n\nAs part of the conference, a structured expert judgment synthesis method was used to formulate a public health research agenda. A total of 110 participants represented diverse scientific disciplines from over 35 countries and global public health implementing partners. The conference used a laddered discussion sprint methodology by rotating participant teams, and a managed follow-up process was used to assemble a research agenda based on the discussion and structured expert feedback. This resulted in a five-workstream frame of the research agenda for infodemic management and 166 suggested research questions. The participants then ranked the questions for feasibility and expected public health impact. The expert consensus was summarized in a public health research agenda that included a list of priority research questions.\n\nThe public health research agenda for infodemic management has five workstreams: (1) measuring and continuously monitoring the impact of infodemics during health emergencies; (2) detecting signals and understanding the spread and risk of infodemics; (3) responding and deploying interventions that mitigate and protect against infodemics and their harmful effects; (4) evaluating infodemic interventions and strengthening the resilience of individuals and communities to infodemics; and (5) promoting the development, adaptation, and application of interventions and toolkits for infodemic management. Each workstream identifies research questions and highlights 49 high priority research questions.\n\nPublic health authorities need to develop, validate, implement, and adapt tools and interventions for managing infodemics in acute public health events in ways that are appropriate for their countries and contexts. Infodemiology provides a scientific foundation to make this possible. This research agenda proposes a structured framework for targeted investment for the scientific community, policy makers, implementing organizations, and other stakeholders to consider.", "doi": "10.2196/30979", "pmid": "34604708", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "v1i1e30979"}, {"db": "pmc", "key": "PMC8448461"}], "notes": [], "created": "2021-10-11T18:01:06.780Z", "modified": "2021-10-11T18:01:08.959Z"}, {"entity": "publication", "iuid": "423363b4198b4e769954473f1692fc8f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/423363b4198b4e769954473f1692fc8f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/423363b4198b4e769954473f1692fc8f"}}, "title": "Systemic Human Neutrophil Lipocalin Associates with Severe Acute Kidney Injury in SARS-CoV-2 Pneumonia.", "authors": [{"family": "B\u00fclow Anderberg", "given": "Sara", "initials": "S"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Eriksson", "given": "Ann-Katrin", "initials": "A"}, {"family": "Venge", "given": "Per", "initials": "P"}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}], "type": "journal article", "published": "2021-09-14", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "10", "issue": "18", "pages": null}, "abstract": "Neutrophils have been suggested mediators of organ dysfunction in COVID-19. The current study investigated if systemic neutrophil activity, estimated by human neutrophil lipocalin (HNL) concentration in peripheral blood, is associated with acute kidney injury (AKI) development. A total of 103 adult patients admitted to intensive care, with PCR-confirmed SARS-CoV-2 infection, were prospectively included (Clinical Trials ID: NCT04316884). HNL was analyzed in plasma (P-HNL Dimer) and in whole blood (B-HNL). The latter after ex vivo activation with N-formyl-methionine-leucine-phenylalanine. All patients developed respiratory dysfunction and 62 (60%) were treated with invasive ventilation. Sixty-seven patients (65%) developed AKI, 18 (17%) progressed to AKI stage 3, and 14 (14%) were treated with continuous renal replacement therapy (CRRT). P-HNL Dimer was higher in patients with invasive ventilation, vasopressors, AKI, AKI stage 3, dialysis, and 30-day mortality (p < 0.001-0.046). B-HNL performed similarly with the exception of mild AKI and mortality (p < 0.001-0.004). The cohort was dichotomized by ROC estimated cutoff concentrations of 13.2 \u00b5g/L and 190 \u00b5g/L for P-HNL Dimer and B-HNL respectively. Increased cumulative risks for AKI, AKI stage 3, and death were observed if above the P-HNL cutoff and for AKI stage 3 if above the B-HNL cutoff. The relative risk of developing AKI stage 3 was nine and 39 times greater if above the cutoffs in plasma and whole blood, respectively, for CRRT eight times greater for both. In conclusion, systemically elevated neutrophil lipocalin, interpreted as increased neutrophil activity, was shown to be associated with an increased risk of severe AKI, renal replacement therapy, and mortality in COVID-19 patients with respiratory failure.", "doi": "10.3390/jcm10184144", "pmid": "34575252", "labels": {"Funder: VR": null, "Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "jcm10184144"}, {"db": "pmc", "key": "PMC8464787"}], "notes": [], "created": "2021-10-11T18:05:16.167Z", "modified": "2022-02-08T19:26:20.749Z"}, {"entity": "publication", "iuid": "8ba2f975b4274347abb1c16e6fdb96ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ba2f975b4274347abb1c16e6fdb96ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ba2f975b4274347abb1c16e6fdb96ef"}}, "title": "COVID-19 in Pregnancy and Early Childhood (COPE): study protocol for a prospective, multicentre biobank, survey and database cohort study.", "authors": [{"family": "Carlsson", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-1414-7279", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2453802e12b43008382f79aebd51ddf.json"}}, {"family": "Bergman", "given": "Lina", "initials": "L", "orcid": "0000-0001-5202-9428", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/edca37463d7c49c79fcdd7793717e1a1.json"}}, {"family": "Zaigham", "given": "Mehreen", "initials": "M", "orcid": "0000-0003-0129-1578", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/168018c2beee4b99868263d77bb67277.json"}}, {"family": "Linden", "given": "Karolina", "initials": "K", "orcid": "0000-0002-2792-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a16575cbdf5a4e0ebab52acaf2404273.json"}}, {"family": "Andersson", "given": "Ola", "initials": "O", "orcid": "0000-0002-3972-0457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77b8a87b252041f094508255b8a43df5.json"}}, {"family": "Veje", "given": "Malin", "initials": "M", "orcid": "0000-0001-5487-0616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de2e59c2ebcf41759a06fda11b6572bd.json"}}, {"family": "Sandstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Wikstr\u00f6m", "given": "Anna-Karin", "initials": "AK"}, {"family": "\u00d6stling", "given": "Hanna", "initials": "H"}, {"family": "Fadl", "given": "Helena", "initials": "H", "orcid": "0000-0002-2691-7525", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18fc6fdc8fee43348cd4283b0ad6334a.json"}}, {"family": "Domell\u00f6f", "given": "Magnus", "initials": "M", "orcid": "0000-0002-0726-7029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8aa25e36cc840e59e8308b8cca886c6.json"}}, {"family": "Blomberg", "given": "Marie", "initials": "M", "orcid": "0000-0003-4679-550X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa8f5a1024fe4cd1b8439ebef8d600c1.json"}}, {"family": "Brismar Wendel", "given": "Sophia", "initials": "S", "orcid": "0000-0002-9401-8062", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bfdd5280d71344dab0a68a2f4a4a2a99.json"}}, {"family": "\u00c5den", "given": "Ulrika", "initials": "U"}, {"family": "Sengpiel", "given": "Verena", "initials": "V", "orcid": "0000-0002-3608-7430", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d43b587b94df49f88177d0c804ba7688.json"}}, {"family": "COPE study group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-09-14", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "9", "pages": "e049376", "issn-l": "2044-6055"}, "abstract": "There is limited knowledge on how the SARS-CoV-2 affects pregnancy outcomes. Studies investigating the impact of COVID-19 in early pregnancy are scarce and information on long-term follow-up is lacking.The purpose of this project is to study the impact of COVID-19 on pregnancy outcomes and long-term maternal and child health by: (1) establishing a database and biobank from pregnant women with COVID-19 and presumably non-infected women and their infants and (2) examining how women and their partners experience pregnancy, childbirth and early parenthood in the COVID-19 pandemic.\n\nThis is a national, multicentre, prospective cohort study involving 27 Swedish maternity units accounting for over 86 000 deliveries/year. Pregnant women are included when they: (1) test positive for SARS-CoV-2 (COVID-19 group) or (2) are non-infected and seek healthcare at one of their routine antenatal visits (screening group). Blood, as well as other biological samples, are collected at different time points during and after pregnancy. Child health up to 4 years of age and parent experience of pregnancy, delivery, early parenthood, healthcare and society in general will be examined using web-based questionnaires based on validated instruments. Short- and long-term health outcomes will be collected from Swedish health registers and the parents' experiences will be studied by performing qualitative interviews.\n\nConfidentiality aspects such as data encryption and storage comply with the General Data Protection Regulation and with ethical committee requirements. This study has been granted national ethical approval by the Swedish Ethical Review Authority (dnr 2020-02189 and amendments 2020-02848, 2020-05016, 2020-06696 and 2021-00870) and national biobank approval by the Biobank V\u00e4st (dnr B2000526:970). Results from the project will be published in peer-reviewed journals.\n\nNCT04433364.", "doi": "10.1136/bmjopen-2021-049376", "pmid": "34521667", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-049376"}, {"db": "pmc", "key": "PMC8441224"}, {"db": "ClinicalTrials.gov", "key": "NCT04433364"}], "notes": [], "created": "2021-09-20T06:23:16.618Z", "modified": "2021-11-19T10:46:33.086Z"}, {"entity": "publication", "iuid": "2893acfc94114a48bcf216469cf5f57e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2893acfc94114a48bcf216469cf5f57e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2893acfc94114a48bcf216469cf5f57e"}}, "title": "The SARS-CoV-2 spike protein is vulnerable to moderate electric fields.", "authors": [{"family": "Arbeitman", "given": "Claudia R", "initials": "CR", "orcid": "0000-0002-8302-6825", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e7be9f3366648e89aabf1604b071cfe.json"}}, {"family": "Rojas", "given": "Pablo", "initials": "P", "orcid": "0000-0003-3692-9228", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee970dfd751549f2ab345dc82dfe7ced.json"}}, {"family": "Ojeda-May", "given": "Pedro", "initials": "P"}, {"family": "Garcia", "given": "Martin E", "initials": "ME", "orcid": "0000-0003-2418-1902", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/001e21f8f9c64da19ba99f3e5d3baaed.json"}}], "type": "journal article", "published": "2021-09-13", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "5407", "issn-l": "2041-1723"}, "abstract": "Most of the ongoing projects aimed at the development of specific therapies and vaccines against COVID-19 use the SARS-CoV-2 spike (S) protein as the main target. The binding of the spike protein with the ACE2 receptor (ACE2) of the host cell constitutes the first and key step for virus entry. During this process, the receptor binding domain (RBD) of the S protein plays an essential role, since it contains the receptor binding motif (RBM), responsible for the docking to the receptor. So far, mostly biochemical methods are being tested in order to prevent binding of the virus to ACE2. Here we show, with the help of atomistic simulations, that external electric fields of easily achievable and moderate strengths can dramatically destabilise the S protein, inducing long-lasting structural damage. One striking field-induced conformational change occurs at the level of the recognition loop L3 of the RBD where two parallel beta sheets, believed to be responsible for a high affinity to ACE2, undergo a change into an unstructured coil, which exhibits almost no binding possibilities to the ACE2 receptor. We also show that these severe structural changes upon electric-field application also occur in the mutant RBDs corresponding to the variants of concern (VOC) B.1.1.7 (UK), B.1.351 (South Africa) and P.1 (Brazil). Remarkably, while the structural flexibility of S allows the virus to improve its probability of entering the cell, it is also the origin of the surprising vulnerability of S upon application of electric fields of strengths at least two orders of magnitude smaller than those required for damaging most proteins. Our findings suggest the existence of a clean physical method to weaken the SARS-CoV-2 virus without further biochemical processing. Moreover, the effect could be used for infection prevention purposes and also to develop technologies for in-vitro structural manipulation of S. Since the method is largely unspecific, it can be suitable for application to other mutations in S, to other proteins of SARS-CoV-2 and in general to membrane proteins of other virus types.", "doi": "10.1038/s41467-021-25478-7", "pmid": "34518528", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-25478-7"}], "notes": [], "created": "2021-09-20T06:28:51.640Z", "modified": "2021-09-20T06:29:03.724Z"}, {"entity": "publication", "iuid": "1e64f19ee90a4d2ea6e4270ab56bdc03", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1e64f19ee90a4d2ea6e4270ab56bdc03.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1e64f19ee90a4d2ea6e4270ab56bdc03"}}, "title": "Psychometric Properties of the Fear of COVID-19 Scale: a Response to Mercado-Lara et al. \"Validity and Reliability of the Spanish Version of Fear of COVID-19 Scale in Colombian Physicians\".", "authors": [{"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "editorial", "published": "2021-09-13", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "pages": "1-3", "issn-l": null}, "abstract": "A paper reporting the psychometric properties of the Spanish Fear of COVID-19 Scale (FCV-19S) among Colombian physicians was recently published in the International Journal of Mental Health and Addiction. Although we welcome the translation and validation of our seven-item scale, this commentary outlines some major concerns we have with the study especially the removal of two items in developing a five-item FCV-19S. Based on these concerns, we strongly recommend that healthcare providers and researchers should use the five-item FCV-19S with caution.", "doi": "10.1007/s11469-021-00635-7", "pmid": "34539280", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "635"}, {"db": "pmc", "key": "PMC8436576"}], "notes": [], "created": "2021-10-10T15:34:42.465Z", "modified": "2021-10-10T15:34:42.495Z"}, {"entity": "publication", "iuid": "d23a819098cf4ae290dac7d35a599b0d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d23a819098cf4ae290dac7d35a599b0d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d23a819098cf4ae290dac7d35a599b0d"}}, "title": "Drawing lessons from the COVID-19 pandemic: Seven obstacles to learning from public inquiries in the wake of the crisis.", "authors": [{"family": "Eriksson", "given": "Kerstin", "initials": "K", "orcid": "0000-0002-0494-0089", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5167d81d812b4c479914399d0906560e.json"}}, {"family": "Staupe-Delgado", "given": "Reidar", "initials": "R", "orcid": "0000-0002-4244-9725", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8585167cd5824e429f1974ebbb254856.json"}}, {"family": "Holst", "given": "J\u00f8rgen", "initials": "J", "orcid": "0000-0001-7850-4493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4cef8db2e53049dcb56e3b94a40ae28d.json"}}], "type": "journal article", "published": "2021-09-13", "journal": {"title": "Risk Hazards Crisis Public Policy", "issn": "1944-4079", "issn-l": null}, "abstract": "On March 11, 2020, the World Health Organization declared the emerging COVID-19 threat a pandemic following the global spread of the virus. A year later, a number of governments are being handed the concluding reports of national public inquiries tasked with investigating responses, mishaps, and identifying lessons for the future. The present article aims to identify a set of learning obstacles that may hinder effective lessons drawing from the COVID-19 pandemic responses. The seven obstacles discussed in this article are: (1) retaining lessons and implementing them effectively, (2) effectively drawing lessons from other countries, (3) the potential for reforms to introduce unanticipated vulnerabilities elsewhere in the system, (4) political pressure, (5) drawing the conclusions from observations, (6) experts versus decision makers, and (7) reforms may not be related to the actual crisis. Exploring these obstacles will be central to future discussions concerning which kinds of responses will set precedent for future pandemics and global health crises.", "doi": "10.1002/rhc3.12240", "pmid": "34909110", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "RHC312240"}, {"db": "pmc", "key": "PMC8662287"}], "notes": [], "created": "2021-12-18T17:50:37.507Z", "modified": "2021-12-18T17:50:52.983Z"}, {"entity": "publication", "iuid": "58eb98e7c803402b8707615116755540", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/58eb98e7c803402b8707615116755540.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/58eb98e7c803402b8707615116755540"}}, "title": "Correction to: The Unyvero Hospital-Acquired pneumonia panel for diagnosis of secondary bacterial pneumonia in COVID-19 patients.", "authors": [{"family": "Tellapragada", "given": "Chaitanya", "initials": "C"}, {"family": "Giske", "given": "Christian G", "initials": "CG"}], "type": "published erratum", "published": "2021-09-13", "journal": {"title": "Eur J Clin Microbiol Infect Dis", "issn": "1435-4373", "issn-l": null}, "abstract": null, "doi": "10.1007/s10096-021-04331-1", "pmid": "34515876", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10096-021-04331-1"}, {"db": "pmc", "key": "PMC8435560"}], "notes": [], "created": "2021-09-20T06:29:31.711Z", "modified": "2021-09-20T06:30:31.524Z"}, {"entity": "publication", "iuid": "46682de72d7b45ba9a99097ebadafc6a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46682de72d7b45ba9a99097ebadafc6a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46682de72d7b45ba9a99097ebadafc6a"}}, "title": "COVID-19 infection among bartenders and waiters before and after pub lockdown.", "authors": [{"family": "Methi", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-7091-0806", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb34bc6f3c664b55b2240d9de0114cd4.json"}}, {"family": "Telle", "given": "Kjetil", "initials": "K"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2021-09-11", "journal": {"title": "Occup Environ Med", "issn": "1470-7926", "issn-l": null}, "abstract": "To assess how different bans on serving alcohol in Norwegian bars and restaurants were related to the detection of SARS-CoV-2 in bartenders and waiters and in persons in any occupation.\n\nIn 25 392 bartenders and waiters and 1 496 328 persons with other occupations (mean (SD) age 42.0 (12.9) years and 51.8% men), we examined the weekly rates of workers tested and detected with SARS-CoV-2, 1-10 weeks before and 1-5 weeks after implementation of different degrees of bans on serving alcohol in pubs and restaurants, across 102 Norwegian municipalities with: (1) full blanket ban, (2) partial ban with hourly restrictions (eg, from 22:00 hours) or (3) no ban, adjusted for age, sex, testing behaviour and population size.\n\nBy 4 weeks after the implementation of ban, COVID-19 infection among bartenders and waiters had been reduced by 60% (from 2.8 (95% CI 2.0 to 3.6) to 1.1 (95% CI 0.5 to 1.6) per 1000) in municipalities introducing full ban, and by almost 50% (from 2.5 (95% CI 1.5 to 3.5) to 1.3 (95% CI 0.4 to 2.2) per 1000) in municipalities introducing partial ban. A similar reduction within 4 weeks was also observed for workers in all occupations, both in municipalities with full (from 1.3 (95% CI 1.3 to 1.4) to 0.9 (95% CI 0.9 to 1.0)) and partial bans (from 1.2 (95% CI 1.1 to 1.3) to 0.5 (95% CI 0.5 to 0.6)).\n\nPartial bans on serving alcohol in bars and restaurants may be similarly associated with declines in confirmed COVID-19 infection as full bans.", "doi": "10.1136/oemed-2021-107502", "pmid": "34510004", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "oemed-2021-107502"}], "notes": [], "created": "2021-09-13T06:32:35.717Z", "modified": "2021-11-18T14:19:01.530Z"}, {"entity": "publication", "iuid": "1cb49e2c4e4246f1b9d225c6f4207247", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1cb49e2c4e4246f1b9d225c6f4207247.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1cb49e2c4e4246f1b9d225c6f4207247"}}, "title": "Unmet need of essential treatments for critical illness in Malawi.", "authors": [{"family": "Kayambankadzanja", "given": "Raphael Kazidule", "initials": "RK", "orcid": "0000-0003-2242-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48591b6c1f8c46b6ad8750de157c98a3.json"}}, {"family": "Schell", "given": "Carl Otto", "initials": "CO", "orcid": "0000-0002-7904-1336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a40b337b45b471d97a102c355c9d874.json"}}, {"family": "Mbingwani", "given": "Isaac", "initials": "I"}, {"family": "Mndolo", "given": "Samson Kwazizira", "initials": "SK"}, {"family": "Castegren", "given": "Markus", "initials": "M"}, {"family": "Baker", "given": "Tim", "initials": "T"}], "type": "journal article", "published": "2021-09-10", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "9", "pages": "e0256361"}, "abstract": "Critical illness is common throughout the world and has been the focus of a dramatic increase in attention during the COVID-19 pandemic. Severely deranged vital signs such as hypoxia, hypotension and low conscious level can identify critical illness. These vital signs are simple to check and treatments that aim to correct derangements are established, basic and low-cost. The aim of the study was to estimate the unmet need of such essential treatments for severely deranged vital signs in all adults admitted to hospitals in Malawi.\r\n\r\nWe conducted a point prevalence cross-sectional study of adult hospitalized patients in Malawi. All in-patients aged \u226518 on single days Queen Elizabeth Central Hospital (QECH) and Chiradzulu District Hospital (CDH) were screened. Patients with hypoxia (oxygen saturation <90%), hypotension (systolic blood pressure <90mmHg) and reduced conscious level (Glasgow Coma Scale <9) were included in the study. The a-priori defined essential treatments were oxygen therapy for hypoxia, intravenous fluid for hypotension and an action to protect the airway for reduced consciousness (placing the patient in the lateral position, insertion of an oro-pharyngeal airway or endo-tracheal tube or manual airway protection).\r\n\r\nOf the 1135 hospital in-patients screened, 45 (4.0%) had hypoxia, 103 (9.1%) had hypotension, and 17 (1.5%) had a reduced conscious level. Of those with hypoxia, 40 were not receiving oxygen (88.9%). Of those with hypotension, 94 were not receiving intravenous fluids (91.3%). Of those with a reduced conscious level, nine were not receiving an action to protect the airway (53.0%).\r\n\r\nThere was a large unmet need of essential treatments for critical illness in two hospitals in Malawi.", "doi": "10.1371/journal.pone.0256361", "pmid": "34506504", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-08206"}], "notes": [], "created": "2021-09-13T06:26:05.344Z", "modified": "2021-11-18T14:18:20.046Z"}, {"entity": "publication", "iuid": "d39b885aacba463da071d6ea31343e2a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d39b885aacba463da071d6ea31343e2a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d39b885aacba463da071d6ea31343e2a"}}, "title": "Outcomes associated with different vaccines in individuals with bipolar disorder and impact on the current COVID-19 pandemic- a systematic review.", "authors": [{"family": "Reininghaus", "given": "Eva Z", "initials": "EZ"}, {"family": "Manchia", "given": "Mirko", "initials": "M"}, {"family": "Dalkner", "given": "Nina", "initials": "N"}, {"family": "Bonkat", "given": "Nina", "initials": "N"}, {"family": "Squassina", "given": "Alessio", "initials": "A"}, {"family": "Hodl", "given": "Isabel", "initials": "I"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Reif", "given": "Andreas", "initials": "A"}, {"family": "Hajek", "given": "Tomas", "initials": "T"}, {"family": "Land\u00e9n", "given": "Mikael", "initials": "M"}, {"family": "Correll", "given": "Christoph U", "initials": "CU"}, {"family": "Scott", "given": "Jan", "initials": "J"}, {"family": "Etain", "given": "Bruno", "initials": "B"}, {"family": "Rietschel", "given": "Marcella", "initials": "M"}, {"family": "Bergink", "given": "Veerle", "initials": "V"}, {"family": "Martinez-Cengotitabengoa", "given": "Monica", "initials": "M"}, {"family": "Kessing", "given": "Lars Vedel", "initials": "LV"}, {"family": "Fagiolini", "given": "Andrea", "initials": "A"}, {"family": "Bauer", "given": "Michael", "initials": "M"}, {"family": "Goodwin", "given": "Guy", "initials": "G"}, {"family": "Gonzalez-Pinto", "given": "Ana", "initials": "A"}, {"family": "Kupka", "given": "Ralph W", "initials": "RW"}, {"family": "Schulze", "given": "Thomas G", "initials": "TG"}, {"family": "Lagerberg", "given": "Trine V", "initials": "TV"}, {"family": "Yildiz", "given": "Ay\u015feg\u00fcl", "initials": "A"}, {"family": "Henry", "given": "Chantal", "initials": "C"}, {"family": "Morken", "given": "Gunnar", "initials": "G"}, {"family": "Ritter", "given": "Phillip", "initials": "P"}, {"family": "Nieslen", "given": "Ren\u00e9 Ernst", "initials": "RE"}, {"family": "Licht", "given": "Rasmus W", "initials": "RW"}, {"family": "Bechdolf", "given": "Andreas", "initials": "A"}, {"family": "Andreassen", "given": "Ole A", "initials": "OA"}, {"family": "Fellendorf", "given": "Frederike Tabea", "initials": "FT"}], "type": "journal article", "published": "2021-09-10", "journal": {"title": "Eur Neuropsychopharmacol", "issn": "1873-7862", "issn-l": null}, "abstract": "Bipolar disorder (BD) might be associated with higher infection rates of coronavirus disease (COVID-19) which in turn could result in worsening the clinical course and outcome. This may be due to a high prevalence of somatic comorbidities and an increased risk of delays in and poorer treatment of somatic disease in patients with severe mental illness in general. Vaccination is the most important public health intervention to tackle the ongoing pandemic. We undertook a systematic review regarding the data on vaccinations in individuals with BD. Proportion of prevalence rates, efficacy and specific side effects of vaccinations and in individuals with BD were searched. Results show that only five studies have investigated vaccinations in individuals with BD, which substantially limits the interpretation of overall findings. Studies on antibody production after vaccinations in BD are very limited and results are inconsistent. Also, the evidence-based science on side effects of vaccinations in individuals with BD so far is poor.", "doi": "10.1016/j.euroneuro.2021.09.001", "pmid": "34607722", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0924-977X(21)00743-4"}, {"db": "pmc", "key": "PMC8429356"}], "notes": [], "created": "2021-10-11T17:55:05.232Z", "modified": "2021-10-11T17:55:05.250Z"}, {"entity": "publication", "iuid": "6cdab3b8bf64424e8314f89437a1daf2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6cdab3b8bf64424e8314f89437a1daf2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6cdab3b8bf64424e8314f89437a1daf2"}}, "title": "Histone H3 Cleavage in Severe COVID-19 ICU Patients.", "authors": [{"family": "Huckriede", "given": "Joram", "initials": "J"}, {"family": "de Vries", "given": "Femke", "initials": "F"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Wichapong", "given": "Kanin", "initials": "K"}, {"family": "Reutelingsperger", "given": "Chris", "initials": "C"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Garcia de Frutos", "given": "Pablo", "initials": "P"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Nicolaes", "given": "Gerry A F", "initials": "GAF"}], "type": "journal article", "published": "2021-09-10", "journal": {"title": "Front Cell Infect Microbiol", "issn": "2235-2988", "volume": "11", "pages": "694186", "issn-l": null}, "abstract": "The severity of coronavirus disease 19 (COVID-19) is associated with neutrophil extracellular trap (NET) formation. During NET formation, cytotoxic extracellular histones are released, the presence of which is linked to the initiation and progression of several acute inflammatory diseases. Here we study the presence and evolution of extracellular histone H3 and several other neutrophil-related molecules and damage-associated molecular patterns (DAMPs) in the plasma of 117 COVID-19-positive ICU patients. We demonstrate that at ICU admission the levels of histone H3, MPO, and DNA-MPO complex were all significantly increased in COVID-19-positive patients compared to control samples. Furthermore, in a subset of 54 patients, the levels of each marker remained increased after 4+ days compared to admission. Histone H3 was found in 28% of the patients on admission to the ICU and in 50% of the patients during their stay at the ICU. Notably, in 47% of histone-positive patients, we observed proteolysis of histone in their plasma. The overall presence of histone H3 during ICU stay was associated with thromboembolic events and secondary infection, and non-cleaved histone H3 was associated with the need for vasoactive treatment, invasive ventilation, and the development of acute kidney injury. Our data support the validity of treatments that aim to reduce NET formation and additionally underscore that more targeted therapies focused on the neutralization of histones should be considered as treatment options for severe COVID-19 patients.", "doi": "10.3389/fcimb.2021.694186", "pmid": "34568088", "labels": {"Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8461091"}], "notes": [], "created": "2021-10-11T18:03:16.463Z", "modified": "2021-10-11T18:03:16.478Z"}, {"entity": "publication", "iuid": "a92858c94ac44fe49013e243adcdf3fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a92858c94ac44fe49013e243adcdf3fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a92858c94ac44fe49013e243adcdf3fd"}}, "title": "A potential increase in adolescent nonsuicidal self-injury during covid-19: A comparison of data from three different time points during 2011 - 2021.", "authors": [{"family": "Zetterqvist", "given": "Maria", "initials": "M"}, {"family": "Jonsson", "given": "Linda S", "initials": "LS"}, {"family": "Landberg", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Svedin", "given": "Carl G\u00f6ran", "initials": "CG"}], "type": "journal article", "published": "2021-09-10", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "volume": "305", "pages": "114208", "issn-l": null}, "abstract": "Life-time prevalence of nonsuicidal self-injury (NSSI) has consistently been found to be around 17% in community samples of adolescents. Concerns of threats to mental health in adolescents during covid-19 have been raised. Life-time prevalence of NSSI in high school students in Sweden was compared using the same item to assess NSSI at three different time points. Results showed very similar prevalence of NSSI in 2011 and 2014 (17.2 % vs. 17.7 %), and an increase to 27.6 % during the pandemic of 2020-2021. Our findings imply a need to highlight the potential psychosocial consequences of covid-19 for young people.", "doi": "10.1016/j.psychres.2021.114208", "pmid": "34543849", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(21)00504-7"}, {"db": "pmc", "key": "PMC8448460"}], "notes": [], "created": "2021-10-10T15:37:09.274Z", "modified": "2021-10-10T15:37:09.284Z"}, {"entity": "publication", "iuid": "db528e826ef244f692dd82d08ecb0d8c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db528e826ef244f692dd82d08ecb0d8c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db528e826ef244f692dd82d08ecb0d8c"}}, "title": "Older adults' experiences of maintaining social participation: Creating opportunities and striving to adapt to changing situations.", "authors": [{"family": "L\u00f6fgren", "given": "Maria", "initials": "M", "orcid": "0000-0002-2403-4761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7013c636d1cb4a6f8e7e9e9ff51123f1.json"}}, {"family": "Larsson", "given": "Ellinor", "initials": "E", "orcid": "0000-0001-8513-0338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ced25f9687c3468ea8bbad6c8d0d23bd.json"}}, {"family": "Isaksson", "given": "Gunilla", "initials": "G", "orcid": "0000-0001-9143-9235", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a9d964a11714d6d86d6c163b645209e.json"}}, {"family": "Nyman", "given": "Anneli", "initials": "A", "orcid": "0000-0003-0467-4857", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48287349613a4cbb92e6023e9c18c335.json"}}], "type": "journal article", "published": "2021-09-09", "journal": {"title": "Scand J Occup Ther", "issn": "1651-2014", "pages": "1-11", "issn-l": null}, "abstract": "Social participation concerns the possibility of engaging in activities in interaction with others or society at large and contributes to the health and well-being of older adults. In contrast, a lack of social participation is associated with loneliness. It is, therefore, important to understand what strategies older adults use to maintain social participation.\n\nTo explore and describe older adults' experiences of maintaining social participation.\n\nNine older adults, aged 69-92 years, participated in interviews that were analysed through qualitative content analysis.\n\nThe overall findings reflect how older adults create opportunities for social participation by developing strategies and striving to adapt to changing situations, emphasizing how maintaining social participation is an active process. Preserving social participation requires motivation and an effort to take initiative to cultivate social relations, maintain community bonds, engage in social events and activities and stay connected with society.\n\nThese results may extend our understanding of strategies that older adults use, as well as the challenges they face when striving to adapt to new circumstances. This study may have implications for the practice of how to support older adults' social participation.", "doi": "10.1080/11038128.2021.1974550", "pmid": "34499845", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-09-13T06:07:30.008Z", "modified": "2021-09-13T06:07:30.131Z"}, {"entity": "publication", "iuid": "61b81c8d424d47928971c9d88be29179", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61b81c8d424d47928971c9d88be29179.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61b81c8d424d47928971c9d88be29179"}}, "title": "Heterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination", "authors": [{"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Vikstr\u00f6m", "given": "Linnea", "initials": "L"}, {"family": "Gwon", "given": "Yong Dae", "initials": "YD"}, {"family": "Persson", "given": "Ida Lisa", "initials": "IL"}, {"family": "Edin", "given": "Alicia", "initials": "A"}, {"family": "Bj\u00f6rsell", "given": "Tove", "initials": "T"}, {"family": "Dernstedt", "given": "Andy", "initials": "A"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Tevell", "given": "Staffan", "initials": "S"}, {"family": "Evander", "given": "Magnus", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Forsell", "given": "Mattias", "initials": "M", "orcid": "0000-0001-6904-742X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e41c0e1c9c7b499fb3d844d4c572e7bb.json"}}], "type": "journal-article", "published": "2021-09-09", "journal": {"title": "N Engl J Med", "issn": "1533-4406", "issn-l": null, "volume": "385", "issue": "11", "pages": "1049-1051"}, "abstract": null, "doi": "10.1056/nejmc2110716", "pmid": "34260850", "labels": {"Research Area: Vaccine": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Drug Discovery": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pmc", "key": "PMC8314734"}], "notes": [], "created": "2021-08-16T14:53:53.615Z", "modified": "2022-02-14T16:26:28.301Z"}, {"entity": "publication", "iuid": "6b6cc99a371b49e892efedf3224ad53d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b6cc99a371b49e892efedf3224ad53d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b6cc99a371b49e892efedf3224ad53d"}}, "title": "Patients with autoimmune polyendocrine syndrome type 1 have an increased susceptibility to severe herpesvirus infections.", "authors": [{"family": "Iivo", "given": "Hetem\u00e4ki", "initials": "H"}, {"family": "Saila", "given": "Laakso", "initials": "L"}, {"family": "Hannamari", "given": "V\u00e4limaa", "initials": "V"}, {"family": "Kleino", "given": "Iivari", "initials": "I"}, {"family": "Kek\u00e4l\u00e4inen", "given": "Eliisa", "initials": "E"}, {"family": "Outi", "given": "M\u00e4kitie", "initials": "M"}, {"family": "Petteri", "given": "Arstila T", "initials": "AT"}], "type": "journal article", "published": "2021-09-08", "journal": {"title": "Clin Immunol", "issn": "1521-7035", "pages": "108851", "issn-l": "1521-6616"}, "abstract": "Almost all patients with autoimmune polyendocrine syndrome type 1 (APS-1) have neutralizing antibodies against type 1 interferons (IFN), important mediators of antiviral defense. Recently, neutralizing anti-IFN antibodies were shown to be a risk factor of severe COVID-19. Here we show in a cohort of 44 patients with APS-1 that higher titers of neutralizing anti-IFN\u03b14 antibodies are associated with a higher and earlier incidence of VZV reactivation (herpes zoster). The patients also present with uncommonly severe clinical sequelae of herpetic infections. APS-1 patients had decreased humoral immune responses to varicella zoster virus, but cellular responses were comparable to healthy controls. These results suggest that blocking the type I interferon pathway in patients with APS-1 patients leads to a clinically significant immune deficiency, and susceptibility to herpesviruses should be taken into account when treating patients with APS-1.", "doi": "10.1016/j.clim.2021.108851", "pmid": "34508889", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1521-6616(21)00188-1"}], "notes": [], "created": "2021-09-13T06:29:34.119Z", "modified": "2021-09-13T06:29:34.132Z"}, {"entity": "publication", "iuid": "7417890877ab4f709614ce6eae82f5ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7417890877ab4f709614ce6eae82f5ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7417890877ab4f709614ce6eae82f5ef"}}, "title": "Autoimmunity roots of the thrombotic events after COVID-19 vaccination.", "authors": [{"family": "Elrashdy", "given": "Fatma", "initials": "F"}, {"family": "Tambuwala", "given": "Murtaza M", "initials": "MM"}, {"family": "Hassan", "given": "Sk Sarif", "initials": "SS"}, {"family": "Adadi", "given": "Parise", "initials": "P"}, {"family": "Seyran", "given": "Murat", "initials": "M"}, {"family": "El-Aziz", "given": "Tarek Mohamed Abd", "initials": "TMA"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Lal", "given": "Amos", "initials": "A"}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA"}, {"family": "Kandimalla", "given": "Ramesh", "initials": "R"}, {"family": "Bazan", "given": "Nicolas G", "initials": "NG"}, {"family": "Azad", "given": "Gajendra Kumar", "initials": "GK"}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Choudhury", "given": "Pabitra Pal", "initials": "PP"}, {"family": "Serrano-Aroca", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "Takayama", "given": "Kazuo", "initials": "K"}, {"family": "Chauhan", "given": "Gaurav", "initials": "G"}, {"family": "Pizzol", "given": "Damiano", "initials": "D"}, {"family": "Barh", "given": "Debmalya", "initials": "D"}, {"family": "Panda", "given": "Pritam Kumar", "initials": "PK"}, {"family": "Mishra", "given": "Yogendra K", "initials": "YK"}, {"family": "Pal\u00f9", "given": "Giorgio", "initials": "G"}, {"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Redwan", "given": "Elrashdy M", "initials": "EM"}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN"}], "type": "journal article", "published": "2021-09-08", "journal": {"title": "Autoimmun Rev", "issn": "1873-0183", "pages": "102941", "issn-l": null}, "abstract": "Although vaccination represents the most promising way to stop or contain the coronavirus disease 2019 (COVID-19) pandemic and safety and effectiveness of available vaccines were proven, a small number of individuals who received anti-SARS-CoV-2 vaccines developed a prothrombotic syndrome. Vaccine-induced immune thrombotic thrombocytopenia (VITT) can be triggered by the adenoviral vector-based vaccine, whereas lipid nanoparticle-mRNA-based vaccines can induce rare cases of deep vein thrombosis (DVT). Although the main pathogenic mechanisms behind this rare phenomenon have not yet been identified, both host and vaccine factors might be involved, with pathology at least in part being related to the vaccine-triggered autoimmune reaction. In this review, we are considering some aspects related to pathogenesis, major risk factors, as well as peculiarities of diagnosis and treatment of this rare condition.", "doi": "10.1016/j.autrev.2021.102941", "pmid": "34508917", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1568-9972(21)00216-0"}], "notes": [], "created": "2021-09-13T06:30:25.627Z", "modified": "2021-09-13T06:30:25.638Z"}, {"entity": "publication", "iuid": "93fcb469798a40c48b23d8aeebf129d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/93fcb469798a40c48b23d8aeebf129d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/93fcb469798a40c48b23d8aeebf129d5"}}, "title": "Repeated Covid-19 Infection Exists: A Case Series From Pakistan.", "authors": [{"family": "Haq", "given": "Zia Ul", "initials": "ZU"}, {"family": "Fazid", "given": "Sheraz", "initials": "S"}, {"family": "Yousafzai", "given": "Yasar Mehmood", "initials": "YM"}, {"family": "Noor", "given": "Mohammad", "initials": "M"}, {"family": "Ibrahimzai", "given": "Arsalan Khan", "initials": "AK"}, {"family": "Iqbal", "given": "Arif", "initials": "A"}, {"family": "Ullah", "given": "Naeem", "initials": "N"}, {"family": "Sherin", "given": "Akhtar", "initials": "A"}], "type": "journal article", "published": "2021-09-07", "journal": {"title": "J Ayub Med Coll Abbottabad", "issn": "1819-2718", "volume": "33", "issue": "3", "pages": "519-522", "issn-l": null}, "abstract": "Protection against SARS-CoV-2 in infected individuals of COVID-19 is lacking. We report a case series of repeated infections of SARS-CoV-2.\n\nA total of 12 patients were identified with repeated infections for SARS-CoV-2 from 25 April 2020 to 16 March 2021 from Pakistan. Repeated infection was defined as diagnosis of the SARS-CoV-2 with real-time reverse transcriptase-polymerase chain reaction (RT-PCR) tests in the first and second phase of infection after complete recovery from the first phase of infection with a negative RT-PCR.\n\nOf the 12 participants, 75% (n=9) were male and mean age of the participants were 40.1\u00b19.7 years. Mean duration between the first and second phase of infection was 184\u00b168.9 days. Patients presenting with mild infection in the first phase largely developed moderate to severe infection in the second phase. None of them were vaccinated.\n\nThe pandemic of COVID-19 is on the rise and repeated infection from SARS-CoV-2 is occurring.", "doi": null, "pmid": "34487669", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "9558/3124"}], "notes": [], "created": "2021-09-09T05:34:50.367Z", "modified": "2021-09-09T05:34:50.391Z"}, {"entity": "publication", "iuid": "94460c8969544292a92f17229253e3f5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/94460c8969544292a92f17229253e3f5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/94460c8969544292a92f17229253e3f5"}}, "title": "Author Response: CSF Biomarkers in Patients With COVID-19 and Neurologic Symptoms: A Case Series.", "authors": [{"family": "Ed\u00e9n", "given": "Arvid", "initials": "A"}], "type": "journal article", "published": "2021-09-07", "journal": {"title": "Neurology", "issn": "1526-632X", "volume": "97", "issue": "10", "pages": "510", "issn-l": "0028-3878"}, "abstract": null, "doi": "10.1212/WNL.0000000000012530", "pmid": "34489344", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "97/10/510"}], "notes": [], "created": "2021-09-09T05:35:27.340Z", "modified": "2023-06-19T14:45:47.724Z"}, {"entity": "publication", "iuid": "467597e93a374a49a004b6609177e767", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/467597e93a374a49a004b6609177e767.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/467597e93a374a49a004b6609177e767"}}, "title": "Update of the European Society for Vascular Surgery (ESVS) 2020 Clinical Practice Guidelines on the Management of Acute Limb Ischaemia in Light of the COVID-19 Pandemic, Based on a Scoping Review of the Literature.", "authors": [{"family": "Jongkind", "given": "Vincent", "initials": "V"}, {"family": "Earnshaw", "given": "Jonothan J", "initials": "JJ"}, {"family": "Bastos Gon\u00e7alves", "given": "Frederico", "initials": "F"}, {"family": "Cochennec", "given": "Frederic", "initials": "F"}, {"family": "Debus", "given": "E Sebastian", "initials": "ES"}, {"family": "Hinchliffe", "given": "Robert", "initials": "R"}, {"family": "Menyhei", "given": "Gabor", "initials": "G"}, {"family": "Svetlikov", "given": "Alexei V", "initials": "AV"}, {"family": "Tshomba", "given": "Yamume", "initials": "Y"}, {"family": "Van Den Berg", "given": "Jos C", "initials": "JC"}, {"family": "Bj\u00f6rck", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2021-09-06", "journal": {"title": "Eur J Vasc Endovasc Surg", "issn": "1532-2165", "issn-l": "1078-5884"}, "abstract": "To perform a scoping review of how patients with COVID-19 are affected by acute limb ischaemia (ALI) and evaluate the recommendations of the 2020 ESVS ALI Guidelines for these patients.\n\nResearch questions were defined, and a systematic literature search was performed following the PRISMA guidelines. Abstracts and unpublished literature were not included. The definition of ALI in this review is in accordance with the ESVS guidelines.\n\nMost identified papers were case reports or case series, although population based data and data from randomised controlled trials were also identified. In total, 114 unique and relevant papers were retrieved. Data were conflicting concerning whether the incidence of ALI increased, or remained unchanged, during the pandemic. Case reports and series reported ALI in patients who were younger and healthier than usual, with a greater proportion affecting the upper limb. Whether or not this is coincidental remains uncertain. The proportion of men/women affected seems unchanged. Most reported cases were in hospitalised patients with severe COVID-19. Patients with ALI as their first manifestation of COVID-19 were reported. Patients with ALI have a worse outcome if they have a simultaneous COVID-19 infection. High levels of D-dimer may predict the occurrence of arterial thromboembolic events in patients with COVID-19. Heparin resistance was observed. Anticoagulation should be given to hospitalised COVID-19 patients in prophylactic dosage. Most of the treatment recommendations from the ESVS Guidelines remained relevant, but the following were modified regarding patients with COVID-19 and ALI: 1) CTA imaging before revascularisation should include the entire aorta and iliac arteries; 2) there should be a high index of suspicion, early testing for COVID-19 infection and protective measures are advised; and 3) there should be preferential use of local or locoregional anaesthesia during revascularisation.\n\nAlthough the epidemiology of ALI has changed during the pandemic, the recommendations of the ESVS ALI Guidelines remain valid. The above mentioned minor modifications should be considered in patients with COVID-19 and ALI.", "doi": "10.1016/j.ejvs.2021.08.028", "pmid": "34686452", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1078-5884(21)00688-2"}, {"db": "pmc", "key": "PMC8418912"}], "notes": [], "created": "2021-10-26T18:17:23.347Z", "modified": "2021-10-26T18:17:23.360Z"}, {"entity": "publication", "iuid": "b4c697717ef34758b986290c183cf508", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b4c697717ef34758b986290c183cf508.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b4c697717ef34758b986290c183cf508"}}, "title": "The Impact of the COVID-19 Pandemic and Societal Infection Control Measures on Children and Adolescents' Mental Health: A Scoping Review.", "authors": [{"family": "Marchi", "given": "Jamile", "initials": "J"}, {"family": "Johansson", "given": "Nina", "initials": "N"}, {"family": "Sarkadi", "given": "Anna", "initials": "A"}, {"family": "Warner", "given": "Georgina", "initials": "G"}], "type": "journal article", "published": "2021-09-06", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "711791", "issn-l": "1664-0640"}, "abstract": "Background: The COVID-19 pandemic is primarily a crisis that affects people's physical health. However, it is well-known from previous epidemics and pandemics that there are other indirect negative impacts on mental health, among others. The purpose of this scoping review was to explore and summarise primary empirical research evidence on how the COVID-19 pandemic and societal infection control measures have impacted children and adolescents' mental health. Methods: A literature search was conducted in five scientific databases: PubMed, APA PsycINFO, Web of Science, CINHAL, and Social Science Premium Collection. The search string was designed using the Population (0-18 years), Exposure (COVID-19), Outcomes (mental health) framework. Mental health was defined broadly, covering mental well-being to mental disorders and psychiatric conditions. Results: Fifty-nine studies were included in the scoping review. Of these, 44 were cross-sectional and 15 were longitudinal studies. Most studies reported negative impact of the COVID-19 pandemic on child and adolescent mental health outcomes, yet the evidence was mixed. This was also the case for studies investigating societal control measures. Strong resilience, positive emotion regulation, physical activity, parental self-efficacy, family functioning and emotional regulation, and social support were reported as protective factors. On the contrary, emotional reactivity and experiential avoidance, exposure to excessive information, COVID-19 school concerns, presence of COVID-19 cases in the community, parental mental health problems, and high internet, social media and video game use were all identified as potentially harmful factors. Conclusions: Due to the methodological heterogeneity of the studies and geographical variation, it is challenging to draw definitive conclusions about the real impact of the COVID-19 pandemic on the mental health of children and adolescents. However, the existing body of research gives some insight to how parents, clinicians and policy makers can take action to mitigate the effects of COVID-19 and control measures. Interventions to promote physical activity and reduce screen time among children and adolescents are recommended, as well as parenting support programs.", "doi": "10.3389/fpsyt.2021.711791", "pmid": "34552516", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8451953"}], "notes": [], "created": "2021-10-27T05:16:37.510Z", "modified": "2021-10-27T05:17:05.092Z"}, {"entity": "publication", "iuid": "1c19c7f89b64441aa4a486609ca8c13f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1c19c7f89b64441aa4a486609ca8c13f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1c19c7f89b64441aa4a486609ca8c13f"}}, "title": "Storying COVID-19: fear, digitalisation, and the transformational potential of storytelling.", "authors": [{"family": "Essebo", "given": "Maja", "initials": "M", "orcid": "0000-0002-7173-2108", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b062eec25a734c4a87676eae288b5926.json"}}], "type": "journal article", "published": "2021-09-06", "journal": {"title": "Sustain Sci", "issn": "1862-4057", "pages": "1-10", "issn-l": null}, "abstract": "Stories are being increasingly recognised for their potential as creators, not only depicters, of change. As such, they are receiving greater interest within sustainability science, not least in the approaches specifically focused on transformative processes of co-creation. But while highly powerful, stories are confined by both inherent and external frameworks that, if not acknowledged, limit their transformative potential. This paper addresses two such critical issues-fear and digitalisation-and discusses the ways in which they influence how and with what effects stories can be told. It uses the COVID-19 pandemic as illustration of storytelling processes and outlines some of the ways in which we can, and cannot, draw parallels between pandemic and climate change storytelling.", "doi": "10.1007/s11625-021-01031-9", "pmid": "34512803", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "1031"}, {"db": "pmc", "key": "PMC8420142"}], "notes": [], "created": "2021-09-20T06:33:49.077Z", "modified": "2021-09-20T06:33:49.136Z"}, {"entity": "publication", "iuid": "2dea08cfe69143f3ab0f641cdcccf415", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2dea08cfe69143f3ab0f641cdcccf415.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2dea08cfe69143f3ab0f641cdcccf415"}}, "title": "Older Persons and the Right to Health in the Nordics during COVID-19.", "authors": [{"family": "\u00d3 Cathaoir", "given": "Katharina", "initials": "K", "orcid": "0000-0002-1535-9134", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0f0c704b3d146a8963031546ad087e9.json"}}, {"family": "Aasen", "given": "Henriette Sinding", "initials": "HS", "orcid": "0000-0002-4122-0902", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df3b82f21dc845749a0c800953237ce9.json"}}, {"family": "Gunnarsd\u00f3ttir", "given": "Hrefna D", "initials": "HD", "orcid": "0000-0001-7276-1587", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3cd2a452745b40c0bb99785a50af9ce1.json"}}, {"family": "Kimmel", "given": "Kaisa-Maria", "initials": "KM", "orcid": "0000-0003-4088-4616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/66cbcab717a94e6aa181fee91897f9cb.json"}}, {"family": "Lohiniva-Kerkel\u00e4", "given": "Mirva", "initials": "M"}, {"family": "Rognlien", "given": "Ida Gundersby", "initials": "IG", "orcid": "0000-0001-8065-6138", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ef852cd476e470ca1805358be2b8a70.json"}}, {"family": "Westerh\u00e4ll", "given": "Lotta Vahlne", "initials": "LV", "orcid": "0000-0002-5031-6236", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8fbf37e787e471988ffb05e9cf48b2f.json"}}], "type": "journal article", "published": "2021-09-06", "journal": {"title": "Eur J Health Law", "issn": "1571-8093", "issn-l": null, "volume": null, "issue": null, "pages": "1-28"}, "abstract": "We reflect on the extent to which Nordic countries have safeguarded the right to health of older persons during the pandemic in 2020. All Nordic states have ratified the International Covenant on Economic, Social and Cultural Rights and thereby committed to recognising the right to health. We use the AAAQ framework developed by the Committee on Economic, Social and Cultural Rights to draw attention to aspects of the respective states' responses. The COVID-19 pandemic has had significant impacts on the health of older persons, from the direct effects of the virus, such as illness and death, to indirect impacts, like isolation and loneliness. We find that Nordic states have at times failed to prioritise the full realisation of the core obligations of the right to health for older persons, namely, non-discrimination and provision of essential healthcare. Resource constraints cannot justify discrimination or failure to respect autonomy, integrity and human dignity.", "doi": "10.1163/15718093-bja10052", "pmid": "34610576", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-10-10T15:28:54.132Z", "modified": "2023-06-19T14:59:44.378Z"}, {"entity": "publication", "iuid": "cd377664d20c4cce90850186a7870427", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd377664d20c4cce90850186a7870427.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd377664d20c4cce90850186a7870427"}}, "title": "Diet quality and risk and severity of COVID-19: a prospective cohort study.", "authors": [{"family": "Merino", "given": "Jordi", "initials": "J", "orcid": "0000-0001-8312-1438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12ab049914a542b39affcfb4196861d2.json"}}, {"family": "Joshi", "given": "Amit D", "initials": "AD", "orcid": "0000-0001-7581-6934", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd29dfe6b8c742c894ca26d217080079.json"}}, {"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Leeming", "given": "Emily R", "initials": "ER", "orcid": "0000-0002-0531-4901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59a9e4a4912f451c861668efdd226c44.json"}}, {"family": "Mazidi", "given": "Mohsen", "initials": "M"}, {"family": "Drew", "given": "David A", "initials": "DA", "orcid": "0000-0002-8813-0816", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd3a2cffdc104f18b8684cf4f27d68b2.json"}}, {"family": "Gibson", "given": "Rachel", "initials": "R"}, {"family": "Graham", "given": "Mark S", "initials": "MS"}, {"family": "Lo", "given": "Chun-Han", "initials": "CH", "orcid": "0000-0001-8202-4513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a0d9111318f4084b64f47b5b56c8c85.json"}}, {"family": "Capdevila", "given": "Joan", "initials": "J"}, {"family": "Murray", "given": "Benjamin", "initials": "B"}, {"family": "Hu", "given": "Christina", "initials": "C"}, {"family": "Selvachandran", "given": "Somesh", "initials": "S"}, {"family": "Hammers", "given": "Alexander", "initials": "A"}, {"family": "Bhupathiraju", "given": "Shilpa N", "initials": "SN"}, {"family": "Sharma", "given": "Shreela V", "initials": "SV"}, {"family": "Sudre", "given": "Carole", "initials": "C"}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Chavarro", "given": "Jorge E", "initials": "JE"}, {"family": "Kwon", "given": "Sohee", "initials": "S"}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874802ae65824a90ba50eabdeabb8356.json"}}, {"family": "Willett", "given": "Walter C", "initials": "WC"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Spector", "given": "Timothy D", "initials": "TD"}, {"family": "Berry", "given": "Sarah", "initials": "S"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}], "type": "journal article", "published": "2021-09-06", "journal": {"title": "Gut", "issn": "1468-3288", "issn-l": null}, "abstract": "Poor metabolic health and unhealthy lifestyle factors have been associated with risk and severity of COVID-19, but data for diet are lacking. We aimed to investigate the association of diet quality with risk and severity of COVID-19 and its interaction with socioeconomic deprivation.\n\nWe used data from 592 571 participants of the smartphone-based COVID-19 Symptom Study. Diet information was collected for the prepandemic period using a short food frequency questionnaire, and diet quality was assessed using a healthful Plant-Based Diet Score, which emphasises healthy plant foods such as fruits or vegetables. Multivariable Cox models were fitted to calculate HRs and 95% CIs for COVID-19 risk and severity defined using a validated symptom-based algorithm or hospitalisation with oxygen support, respectively.\n\nOver 3 886 274 person-months of follow-up, 31 815 COVID-19 cases were documented. Compared with individuals in the lowest quartile of the diet score, high diet quality was associated with lower risk of COVID-19 (HR 0.91; 95% CI 0.88 to 0.94) and severe COVID-19 (HR 0.59; 95% CI 0.47 to 0.74). The joint association of low diet quality and increased deprivation on COVID-19 risk was higher than the sum of the risk associated with each factor alone (Pinteraction=0.005). The corresponding absolute excess rate per 10 000 person/months for lowest vs highest quartile of diet score was 22.5 (95% CI 18.8 to 26.3) among persons living in areas with low deprivation and 40.8 (95% CI 31.7 to 49.8) among persons living in areas with high deprivation.\n\nA diet characterised by healthy plant-based foods was associated with lower risk and severity of COVID-19. This association may be particularly evident among individuals living in areas with higher socioeconomic deprivation.", "doi": "10.1136/gutjnl-2021-325353", "pmid": "34489306", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "gutjnl-2021-325353"}], "notes": [], "created": "2021-09-09T05:35:10.324Z", "modified": "2021-09-09T05:35:10.430Z"}, {"entity": "publication", "iuid": "2f9299a3575e47c8a8e24ac9d6b3861a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2f9299a3575e47c8a8e24ac9d6b3861a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2f9299a3575e47c8a8e24ac9d6b3861a"}}, "title": "Innovative software systems for managing the impact of the COVID-19 pandemic.", "authors": [{"family": "Gill", "given": "Sukhpal Singh", "initials": "SS", "orcid": "0000-0002-3913-0369", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a5ab1ac135540acbd401a52536dd989.json"}}, {"family": "Vinuesa", "given": "Ricardo", "initials": "R", "orcid": "0000-0001-6570-5499", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/145cde54ca084cc6875f33fd7219cfc0.json"}}, {"family": "Balasubramanian", "given": "Venki", "initials": "V", "orcid": "0000-0001-6686-4424", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/876332738b834ed68f85594fe8516d8e.json"}}, {"family": "Ghosh", "given": "Soumya K", "initials": "SK", "orcid": "0000-0001-8359-581X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64a1a896d36a496ba60198a898d55a5d.json"}}], "type": "editorial", "published": "2021-09-05", "journal": {"title": "Softw Pract Exp", "issn": "0038-0644", "issn-l": null}, "abstract": null, "doi": "10.1002/spe.3023", "pmid": "34908601", "labels": {"Type: Other": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "SPE3023"}, {"db": "pmc", "key": "PMC8662097"}], "notes": [], "created": "2021-12-18T17:51:25.701Z", "modified": "2021-12-18T17:51:25.862Z"}, {"entity": "publication", "iuid": "351098c9c8274fe6ae586872001b4b7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/351098c9c8274fe6ae586872001b4b7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/351098c9c8274fe6ae586872001b4b7a"}}, "title": "DNA methylome-based validation of induced sputum as an effective protocol to study lung immunity: construction of a classifier of pulmonary cell types.", "authors": [{"family": "Das", "given": "Jyotirmoy", "initials": "J", "orcid": "0000-0002-5649-4658", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/883ec5a66e47458fa303f9df2572f669.json"}}, {"family": "Idh", "given": "Nina", "initials": "N"}, {"family": "Sikkeland", "given": "Liv Ingunn Bjoner", "initials": "LIB"}, {"family": "Paues", "given": "Jakob", "initials": "J"}, {"family": "Lerm", "given": "Maria", "initials": "M", "orcid": "0000-0002-5092-9892", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a326e1fb7efa4c4f8f59e7572f6b83bc.json"}}], "type": "journal article", "published": "2021-09-05", "journal": {"title": "Epigenetics", "issn": "1559-2308", "pages": "1-12", "issn-l": null}, "abstract": "Flow cytometry is a classical approach used to define cell types in peripheral blood. While DNA methylation signatures have been extensively employed in recent years as an alternative to flow cytometry to define cell populations in peripheral blood, this approach has not been tested in lung-derived samples. Here, we compared bronchoalveolar lavage with a more cost-effective and less invasive technique based on sputum induction and developed a DNA methylome-based algorithm that can be used to deconvolute the cell types in such samples. We analysed the DNA methylome profiles of alveolar macrophages and lymphocytes cells isolated from the pulmonary compartment. The cells were isolated using two different methods, sputum induction and bronchoalveolar lavage. A strong positive correlation between the DNA methylome profiles of cells obtained with the two isolation methods was found. We observed the best correlation of the DNA methylomes when both isolation methods captured cells from the lower parts of the lungs. We also identified unique patterns of CpG methylation in DNA obtained from the two cell populations, which can be used as a signature to discriminate between the alveolar macrophages and lymphocytes by means of open-source algorithms. We validated our findings with external data and obtained results consistent with the previous findings. Our analysis opens up a new possibility to identify different cell populations from lung samples and promotes sputum induction as a tool to study immune cell populations from the lung.", "doi": "10.1080/15592294.2021.1969499", "pmid": "34482796", "labels": {"Funder: Hj\u00e4rt-Lungfonden": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://github.com/JD2112/AlveolarCellTypeDeconvolution", "description": "R scripts to analyze the Alveolar macrophages (HLA-DR+/CD3-) and lymphocytes (CD3+) specific cell types from DNA methylation analysis"}], "notes": [], "created": "2021-11-18T13:11:18.641Z", "modified": "2021-11-18T13:16:03.696Z"}, {"entity": "publication", "iuid": "e63ca637474a43d4b0632bdaa2cc9a0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e63ca637474a43d4b0632bdaa2cc9a0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e63ca637474a43d4b0632bdaa2cc9a0e"}}, "title": "The Impact of the COVID-19 Pandemic on Students' Mental Health and Sleep in Saudi Arabia.", "authors": [{"family": "Alyoubi", "given": "Azizah", "initials": "A"}, {"family": "Halstead", "given": "Elizabeth J", "initials": "EJ", "orcid": "0000-0002-5633-1859", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/139cecf838f041729fc9fa6e6a5bf725.json"}}, {"family": "Zambelli", "given": "Zoe", "initials": "Z"}, {"family": "Dimitriou", "given": "Dagmara", "initials": "D", "orcid": "0000-0002-6856-0595", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5de719ff390b404e8a7328a590ee500d.json"}}], "type": "journal article", "published": "2021-09-04", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "17", "pages": null}, "abstract": "Mental health problems are prevalent among university students in Saudi Arabia. This study aimed to investigate the impact of the COVID-19 pandemic on university students' mental health and sleep in Saudi Arabia.\r\n\r\nA total of 582 undergraduate students from Saudi Arabia aged between 18 and 45 years old (M = 20.91, SD = 3.17) completed a cross-sectional online questionnaire measuring depression, anxiety, stress, resilience, and insomnia during the COVID-19 pandemic (2020). Analysis included an independent samples t-test, one-way ANOVA, and Hierarchical regression analysis.\r\n\r\nUndergraduate students reported high levels of depression, anxiety, and perceived stress and low levels of resilience (p < 0.001) during the pandemic. In addition, students reported experiencing insomnia. A hierarchical regression analysis indicated that lower resilience, high levels of insomnia, having a pre-existing mental health condition, and learning difficulties (such as dyslexia, dyspraxia, or dyscalculia) were significantly associated with high levels of depression and stress. In addition, lower resilience, a high level of insomnia, and pre-existing mental health conditions were significantly associated with high levels of anxiety. Finally, a lower level of psychological resilience and a high level of insomnia were significantly associated with increased levels of depression, anxiety and stress within university students.\r\n\r\nThis study has provided evidence that a lower level of psychological resilience and insomnia were associated with mental health problems among undergraduate students in Saudi Arabia, thus enhancing psychological resilience and interventions to support sleep and mental health are vital to support student well-being outcomes throughout the pandemic.", "doi": "10.3390/ijerph18179344", "pmid": "34501935", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph18179344"}], "notes": [], "created": "2021-09-13T06:25:17.108Z", "modified": "2021-11-18T14:11:36.793Z"}, {"entity": "publication", "iuid": "371aa054a56c4cccace10eb7bfd8e9f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/371aa054a56c4cccace10eb7bfd8e9f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/371aa054a56c4cccace10eb7bfd8e9f2"}}, "title": "The Rapid Implementation of a Psychological Support Model for Frontline Healthcare Workers During the COVID-19 Pandemic: A Case Study and Process Evaluation.", "authors": [{"family": "Appelbom", "given": "Sophia", "initials": "S"}, {"family": "Bujacz", "given": "Aleksandra", "initials": "A"}, {"family": "Finnes", "given": "Anna", "initials": "A"}, {"family": "Ahlbeck", "given": "Karsten", "initials": "K"}, {"family": "Bromberg", "given": "Filip", "initials": "F"}, {"family": "Holmberg", "given": "Johan", "initials": "J"}, {"family": "Larsson", "given": "Liv", "initials": "L"}, {"family": "Olgren", "given": "Birgitta", "initials": "B"}, {"family": "Wanecek", "given": "Michael", "initials": "M"}, {"family": "Wetterborg", "given": "Dan", "initials": "D"}, {"family": "Wicksell", "given": "Rikard", "initials": "R"}], "type": "journal article", "published": "2021-09-03", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "713251", "issn-l": "1664-0640"}, "abstract": "The COVID-19 pandemic highlighted the need for psychological support initiatives directed toward frontline healthcare workers, which can be rapidly and sustainably implemented during an infectious disease outbreak. The current case study presents a comprehensive model of psychological support that was implemented at an intensive care unit (ICU) during the first wave of the COVID-19 pandemic. The psychological support model aimed at promoting a resilient stress reaction among frontline staff by protecting physical, social, and psychological resources. The initiatives, targeting different groups of workers, included education and training, peer support, psychologist-supervised and unsupervised group sessions, on-boarding for transferred staff, manager support, and individual sessions for workers experiencing strong stress reactions. The results of the process evaluation of this rapid implementation suggest that peer support initiatives as well as daily group sessions were the most appreciated forms of psychological support. Psychologists involved in organizing and providing the support highlighted several aspects of a successful implementation of the support model: offering support during work hours (preferably after shift), positive attitude of line managers that framed support initiatives as a team effort, and involvement of experienced psychologists able to quickly adjust the content of the support according to the current needs. The study also identified two main problems of the current implementation: the lack of efficient planning due to the use of volunteer work and the need for more structural resources on the organizational level to ensure long-term sustainability of the support model and its implementation among all groups of healthcare staff. The current case study highlights the importance of establishing permanent structural resources and routines for psychological support integrated in clinical practice by healthcare organizations to improve both rapid and sustainable response to future crises.", "doi": "10.3389/fpsyt.2021.713251", "pmid": "34539465", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8446385"}], "notes": [], "created": "2021-09-23T05:19:09.231Z", "modified": "2021-10-10T15:35:07.711Z"}, {"entity": "publication", "iuid": "6ad5487667444cb69faecd064e442597", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ad5487667444cb69faecd064e442597.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ad5487667444cb69faecd064e442597"}}, "title": "Fear During COVID-19 pandemic: Fear of COVID-19 Scale Measurement Properties.", "authors": [{"family": "Ullah", "given": "Irfan", "initials": "I", "orcid": "0000-0003-1100-101X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8d5a7e15ae6487cbdda0de3b2a531c3.json"}}, {"family": "Jaguga", "given": "Florence", "initials": "F", "orcid": "0000-0002-8381-6309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1abd85e0b8ec4d64afe50bf337816121.json"}}, {"family": "Ransing", "given": "Ramdas", "initials": "R"}, {"family": "Pereira-Sanchez", "given": "Victor", "initials": "V", "orcid": "0000-0002-2576-1549", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/244ab7530cd544b69173751dd9ca1cc6.json"}}, {"family": "Orsolini", "given": "Laura", "initials": "L", "orcid": "0000-0002-6882-3770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5aa4ac3eb4e44e208810fed3a72275be.json"}}, {"family": "Ori", "given": "Dorottya", "initials": "D", "orcid": "0000-0003-0878-165X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae84a3d4e3f047349ef01305a75cac8a.json"}}, {"family": "de Filippis", "given": "Renato", "initials": "R", "orcid": "0000-0001-6928-1224", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d34493cdd004ea7926df58f411980bf.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}, {"family": "Adiukwu", "given": "Frances", "initials": "F", "orcid": "0000-0001-5543-1746", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41005a01477f44f995d839aacb60c8c9.json"}}, {"family": "Kilic", "given": "Ozge", "initials": "O", "orcid": "0000-0001-9764-343X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bef5a352062d42b8a18f30db5cd739c9.json"}}, {"family": "Hayatudeen", "given": "Nafisatu", "initials": "N"}, {"family": "Shoib", "given": "Sheikh", "initials": "S", "orcid": "0000-0002-3739-706X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8836f5d9f2a94346b1895a991b2ea5cc.json"}}, {"family": "Ojeahere", "given": "Margaret Isioma", "initials": "MI", "orcid": "0000-0002-0593-2400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/746f8d758e1d4384bca4c0a68d07eed4.json"}}, {"family": "Nagendrappa", "given": "Sachin", "initials": "S", "orcid": "0000-0002-8682-2982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d10848bc08245fc8668221fd48d5806.json"}}, {"family": "Handuleh", "given": "Jibril I M", "initials": "JIM", "orcid": "0000-0003-2662-1078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/266f47402be1449b8875f528d9f27e62.json"}}, {"family": "Dashi", "given": "Elona", "initials": "E", "orcid": "0000-0002-9280-2734", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df7ff12c423f471287b289ccdba40fdb.json"}}, {"family": "Musami", "given": "Umar Baba", "initials": "UB", "orcid": "0000-0003-3540-4120", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dcb21581a7ae43db9a449a79230a1d5b.json"}}, {"family": "Vahdani", "given": "Bita", "initials": "B", "orcid": "0000-0002-5727-8359", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a744c856d694c7c8c1a49396989a856.json"}}, {"family": "Ashrafi", "given": "Agaah", "initials": "A", "orcid": "0000-0003-1145-8001", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00434a52d4234c02871215b9c2c34feb.json"}}, {"family": "Jatchavala", "given": "Chonnakarn", "initials": "C", "orcid": "0000-0001-9765-2184", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2450b1839b534304859eeab927f8f138.json"}}, {"family": "Abbass", "given": "Zargham", "initials": "Z", "orcid": "0000-0002-5288-1079", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb121e28aa4b4c0ea21ba294f60773c4.json"}}, {"family": "El Halabi", "given": "Sarah", "initials": "S"}, {"family": "Ogunnubi", "given": "Oluseun Peter", "initials": "OP", "orcid": "0000-0001-9997-3379", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/17ebbf90d8fd48f9bc69a85d022929ea.json"}}, {"family": "Pinto da Costa", "given": "Mariana", "initials": "M"}, {"family": "Ramalho", "given": "Rodrigo", "initials": "R", "orcid": "0000-0002-2372-6854", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b990d3c278047a9b3878d47316ea4ed.json"}}], "type": "journal article", "published": "2021-09-03", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "issn-l": null, "volume": null, "issue": null, "pages": "1-10"}, "abstract": null, "doi": "10.1007/s11469-021-00528-9", "pmid": "34512215", "labels": {"Category: Public Health": null, "Type: Other": null}, "xrefs": [{"db": "pii", "key": "528"}, {"db": "pmc", "key": "PMC8415186"}], "notes": [], "created": "2021-09-20T06:35:03.095Z", "modified": "2021-11-18T14:11:04.137Z"}, {"entity": "publication", "iuid": "7144f9cd2f3f4eb782a60af0a795a9b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7144f9cd2f3f4eb782a60af0a795a9b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7144f9cd2f3f4eb782a60af0a795a9b2"}}, "title": "Autoimmune hepatitis triggered by COVID-19: A report of two cases.", "authors": [{"family": "Kaba\u00e7am", "given": "G\u00f6khan", "initials": "G"}, {"family": "Wahlin", "given": "Staffan", "initials": "S"}, {"family": "Efe", "given": "Cumali", "initials": "C", "orcid": "0000-0001-6593-5702", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cd621ab96e04e678b0188c48d54b90a.json"}}], "type": "letter", "published": "2021-09-03", "journal": {"title": "Liver Int", "issn": "1478-3231", "issn-l": null}, "abstract": null, "doi": "10.1111/liv.15044", "pmid": "34478591", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-09-06T05:53:14.195Z", "modified": "2021-09-06T05:53:14.253Z"}, {"entity": "publication", "iuid": "e4b92774ea2c47e1b13c32effc754650", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e4b92774ea2c47e1b13c32effc754650.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e4b92774ea2c47e1b13c32effc754650"}}, "title": "Assessing the capacity of symptom scores to predict COVID-19 positivity in Nigeria: a national derivation and validation cohort study.", "authors": [{"family": "Elimian", "given": "Kelly Osezele", "initials": "KO", "orcid": "0000-0003-2729-1613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/695dddf720414c3585d35b30184f0178.json"}}, {"family": "Aderinola", "given": "Olaolu", "initials": "O"}, {"family": "Gibson", "given": "Jack", "initials": "J"}, {"family": "Myles", "given": "Puja", "initials": "P"}, {"family": "Ochu", "given": "Chinwe Lucia", "initials": "CL", "orcid": "0000-0002-0630-7332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f390fa99a654ff899f5e9df6fbaf88e.json"}}, {"family": "King", "given": "Carina", "initials": "C"}, {"family": "Okwor", "given": "Tochi", "initials": "T"}, {"family": "Gaudenzi", "given": "Giulia", "initials": "G", "orcid": "0000-0003-4923-6965", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ee3937112f5484ab9acb5c54e4fabb4.json"}}, {"family": "Olayinka", "given": "Adebola", "initials": "A"}, {"family": "Zaiyad", "given": "Habib Garba", "initials": "HG"}, {"family": "Ohonsi", "given": "Cornelius", "initials": "C"}, {"family": "Ebhodaghe", "given": "Blessing", "initials": "B"}, {"family": "Dan-Nwafor", "given": "Chioma", "initials": "C"}, {"family": "Nwachukwu", "given": "William", "initials": "W"}, {"family": "Abdus-Salam", "given": "Ismail Adeshina", "initials": "IA"}, {"family": "Akande", "given": "Oluwatosin Wuraola", "initials": "OW", "orcid": "0000-0001-6906-895X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7ce51eb7a0b4a04b6af2802c88e2290.json"}}, {"family": "Falodun", "given": "Olanrewaju", "initials": "O"}, {"family": "Arinze", "given": "Chinedu", "initials": "C"}, {"family": "Ezeokafor", "given": "Chidiebere", "initials": "C"}, {"family": "Jafiya", "given": "Abubakar", "initials": "A"}, {"family": "Ojimba", "given": "Anastacia", "initials": "A"}, {"family": "Aremu", "given": "John Tunde", "initials": "JT"}, {"family": "Joseph", "given": "Emmanuel", "initials": "E"}, {"family": "Bowale", "given": "Abimbola", "initials": "A"}, {"family": "Mutiu", "given": "Bamidele", "initials": "B"}, {"family": "Saka", "given": "Babatunde", "initials": "B"}, {"family": "Jinadu", "given": "Arisekola", "initials": "A"}, {"family": "Hamza", "given": "Khadeejah", "initials": "K"}, {"family": "Ibeh", "given": "Christian", "initials": "C"}, {"family": "Bello", "given": "Shaibu", "initials": "S"}, {"family": "Asuzu", "given": "Michael", "initials": "M"}, {"family": "Mba", "given": "Nwando", "initials": "N"}, {"family": "Oladejo", "given": "John", "initials": "J"}, {"family": "Ilori", "given": "Elsie", "initials": "E"}, {"family": "Alfv\u00e9n", "given": "Tobias", "initials": "T"}, {"family": "Igumbor", "given": "Ehimario", "initials": "E"}, {"family": "Ihekweazu", "given": "Chikwe", "initials": "C"}], "type": "journal article", "published": "2021-09-03", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "9", "pages": "e049699"}, "abstract": "This study aimed to develop and validate a symptom prediction tool for COVID-19 test positivity in Nigeria.\r\n\r\nPredictive modelling study.\r\n\r\nAll Nigeria States and the Federal Capital Territory.\r\n\r\nA cohort of 43 221 individuals within the national COVID-19 surveillance dataset from 27 February to 27 August 2020. Complete dataset was randomly split into two equal halves: derivation and validation datasets. Using the derivation dataset (n=21 477), backward multivariable logistic regression approach was used to identify symptoms positively associated with COVID-19 positivity (by real-time PCR) in children (\u226417 years), adults (18-64 years) and elderly (\u226565 years) patients separately.\r\n\r\nWeighted statistical and clinical scores based on beta regression coefficients and clinicians' judgements, respectively. Using the validation dataset (n=21 744), area under the receiver operating characteristic curve (AUROC) values were used to assess the predictive capacity of individual symptoms, unweighted score and the two weighted scores.\r\n\r\nOverall, 27.6% of children (4415/15 988), 34.6% of adults (9154/26 441) and 40.0% of elderly (317/792) that had been tested were positive for COVID-19. Best individual symptom predictor of COVID-19 positivity was loss of smell in children (AUROC 0.56, 95% CI 0.55 to 0.56), either fever or cough in adults (AUROC 0.57, 95% CI 0.56 to 0.58) and difficulty in breathing in the elderly (AUROC 0.53, 95% CI 0.48 to 0.58) patients. In children, adults and the elderly patients, all scoring approaches showed similar predictive performance.\r\n\r\nThe predictive capacity of various symptom scores for COVID-19 positivity was poor overall. However, the findings could serve as an advocacy tool for more investments in resources for capacity strengthening of molecular testing for COVID-19 in Nigeria.", "doi": "10.1136/bmjopen-2021-049699", "pmid": "34479936", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-049699"}], "notes": [], "created": "2021-09-06T05:52:44.836Z", "modified": "2021-11-18T14:05:33.826Z"}, {"entity": "publication", "iuid": "462683b358b4463eb5acc3d9c705555b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/462683b358b4463eb5acc3d9c705555b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/462683b358b4463eb5acc3d9c705555b"}}, "title": "Separable Microneedle Patch to Protect and Deliver DNA Nanovaccines Against COVID-19.", "authors": [{"family": "Yin", "given": "Yue", "initials": "Y"}, {"family": "Su", "given": "Wen", "initials": "W"}, {"family": "Zhang", "given": "Jie", "initials": "J"}, {"family": "Huang", "given": "Wenping", "initials": "W"}, {"family": "Li", "given": "Xiaoyang", "initials": "X"}, {"family": "Ma", "given": "Haixia", "initials": "H"}, {"family": "Tan", "given": "Mixiao", "initials": "M"}, {"family": "Song", "given": "Haohao", "initials": "H"}, {"family": "Cao", "given": "Guoliang", "initials": "G"}, {"family": "Yu", "given": "Shengji", "initials": "S"}, {"family": "Yu", "given": "Di", "initials": "D"}, {"family": "Jeong", "given": "Ji Hoon", "initials": "JH", "orcid": "0000-0002-4836-3551", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25ee9be966af4ebb9451f2a155ce453d.json"}}, {"family": "Zhao", "given": "Xiao", "initials": "X"}, {"family": "Li", "given": "Hui", "initials": "H"}, {"family": "Nie", "given": "Guangjun", "initials": "G", "orcid": "0000-0001-5040-9793", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bcb72746a3f4aa29992a27de22194b8.json"}}, {"family": "Wang", "given": "Hai", "initials": "H", "orcid": "0000-0002-1292-998X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db9fc13e307a43f48ca4bf63121051b1.json"}}], "type": "journal article", "published": "2021-09-02", "journal": {"title": "ACS Nano", "issn": "1936-086X", "issn-l": null}, "abstract": "The successful control of coronavirus disease 2019 (COVID-19) pandemic is not only relying on the development of vaccines, but also depending on the storage, transportation, and administration of vaccines. Ideally, nucleic acid vaccine should be directly delivered to proper immune cells or tissue (such as lymph nodes). However, current developed vaccines are normally treated through intramuscular injection, where immune cells do not normally reside. Meanwhile, current nucleic acid vaccines must be stored in a frozen state that may hinder their application in developing countries. Here, we report a separable microneedle (SMN) patch to deliver polymer encapsulated spike (or nucleocapsid) protein encoding DNA vaccines and immune adjuvant for efficient immunization. Compared with intramuscular injection, SMN patch can deliver nanovaccines into intradermal for inducing potent and durable adaptive immunity. IFN-\u03b3+CD4/8+ and IL-2+CD4/8+ T cells or virus specific IgG are significantly increased after vaccination. Moreover, in vivo results show the SMN patches can be stored at room temperature for at least 30 days without decreases in immune responses. These features of nanovaccines-laden SMN patch are important for developing advanced COVID-19 vaccines with global accessibility.", "doi": "10.1021/acsnano.1c03252", "pmid": "34472328", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-09-06T06:09:51.779Z", "modified": "2021-11-19T10:51:08.506Z"}, {"entity": "publication", "iuid": "78a51e65b378445a8fab820383056a5d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/78a51e65b378445a8fab820383056a5d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/78a51e65b378445a8fab820383056a5d"}}, "title": "Physiological respiratory parameters in pre-hospital patients with suspected COVID-19: A prospective cohort study.", "authors": [{"family": "M\u00e4lberg", "given": "Johan", "initials": "J", "orcid": "0000-0003-4289-8202", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f90af5371ce94f988a9f99a74306ab55.json"}}, {"family": "Hadziosmanovic", "given": "Nermin", "initials": "N"}, {"family": "Smekal", "given": "David", "initials": "D"}], "type": "journal article", "published": "2021-09-02", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "9", "pages": "e0257018", "issn-l": "1932-6203"}, "abstract": "The COVID-19 pandemic has presented emergency medical services (EMS) worldwide with the difficult task of identifying patients with COVID-19 and predicting the severity of their illness. The aim of this study was to investigate whether physiological respiratory parameters in pre-hospital patients with COVID-19 differed from those without COVID-19 and if they could be used to aid EMS personnel in the prediction of illness severity.\n\nPatients with suspected COVID-19 were included by EMS personnel in Uppsala, Sweden. A portable respiratory monitor based on pneumotachography was used to sample the included patient's physiological respiratory parameters. A questionnaire with information about present symptoms and background data was completed. COVID-19 diagnoses and hospital admissions were gathered from the electronic medical record system. The physiological respiratory parameters of patients with and without COVID-19 were then analyzed using descriptive statistical analysis and logistic regression.\n\nBetween May 2020 and January 2021, 95 patients were included, and their physiological respiratory parameters analyzed. Of these patients, 53 had COVID-19. Using adjusted logistic regression, the odds of having COVID-19 increased with respiratory rate (95% CI 1.000-1.118), tidal volume (95% CI 0.996-0.999) and negative inspiratory pressure (95% CI 1.017-1.152). Patients admitted to hospital had higher respiratory rates (p<0.001) and lower tidal volume (p = 0.010) compared to the patients who were not admitted. Using adjusted logistic regression, the odds of hospital admission increased with respiratory rate (95% CI 1.081-1.324), rapid shallow breathing index (95% CI 1.006-1.040) and dead space percentage of tidal volume (95% CI 1.027-1.159).\n\nPatients taking smaller, faster breaths with less pressure had higher odds of having COVID-19 in this study. Smaller, faster breaths and higher dead space percentage also increased the odds of hospital admission. Physiological respiratory parameters could be a useful tool in detecting COVID-19 and predicting hospital admissions, although more research is needed.", "doi": "10.1371/journal.pone.0257018", "pmid": "34473782", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-15446"}, {"db": "pmc", "key": "PMC8412304"}], "notes": [], "created": "2021-09-06T06:07:22.950Z", "modified": "2021-09-06T06:08:45.240Z"}, {"entity": "publication", "iuid": "bf9c58a68f07472384d6c71dcc2dc436", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf9c58a68f07472384d6c71dcc2dc436.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf9c58a68f07472384d6c71dcc2dc436"}}, "title": "Impact of the COVID-19 pandemic on the surveillance, prevention and control of antimicrobial resistance: a global survey.", "authors": [{"family": "Tomczyk", "given": "Sara", "initials": "S", "orcid": "0000-0001-6975-2663", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/547fdb65afe640fbb3f09de07366555b.json"}}, {"family": "Taylor", "given": "Angelina", "initials": "A"}, {"family": "Brown", "given": "Allison", "initials": "A"}, {"family": "de Kraker", "given": "Marlieke E A", "initials": "MEA", "orcid": "0000-0003-0903-8614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0791cb6f63f445a087fbb50ddf70a105.json"}}, {"family": "El-Saed", "given": "Aiman", "initials": "A"}, {"family": "Alshamrani", "given": "Majid", "initials": "M"}, {"family": "Hendriksen", "given": "Rene S", "initials": "RS"}, {"family": "Jacob", "given": "Megan", "initials": "M"}, {"family": "L\u00f6fmark", "given": "Sonja", "initials": "S"}, {"family": "Perovic", "given": "Olga", "initials": "O", "orcid": "0000-0001-5580-4629", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3353252a919e40069dd4b0235c672499.json"}}, {"family": "Shetty", "given": "Nandini", "initials": "N"}, {"family": "Sievert", "given": "Dawn", "initials": "D"}, {"family": "Smith", "given": "Rachel", "initials": "R"}, {"family": "Stelling", "given": "John", "initials": "J"}, {"family": "Thakur", "given": "Siddhartha", "initials": "S"}, {"family": "Vietor", "given": "Ann Christin", "initials": "AC"}, {"family": "Eckmanns", "given": "Tim", "initials": "T"}], "type": "journal article", "published": "2021-09-02", "journal": {"title": "J Antimicrob Chemother", "issn": "1460-2091", "issn-l": null}, "abstract": "The COVID-19 pandemic has had a substantial impact on health systems. The WHO Antimicrobial Resistance (AMR) Surveillance and Quality Assessment Collaborating Centres Network conducted a survey to assess the effects of COVID-19 on AMR surveillance, prevention and control.\n\nFrom October to December 2020, WHO Global Antimicrobial Resistance and Use Surveillance System (GLASS) national focal points completed a questionnaire, including Likert scales and open-ended questions. Data were descriptively analysed, income/regional differences were assessed and free-text questions were thematically analysed.\n\nSeventy-three countries across income levels participated. During the COVID-19 pandemic, 67% reported limited ability to work with AMR partnerships; decreases in funding were frequently reported by low- and middle-income countries (LMICs; P < 0.01). Reduced availability of nursing, medical and public health staff for AMR was reported by 71%, 69% and 64%, respectively, whereas 67% reported stable cleaning staff availability. The majority (58%) reported reduced reagents/consumables, particularly LMICs (P < 0.01). Decreased numbers of cultures, elective procedures, chronically ill admissions and outpatients and increased ICU admissions reported could bias AMR data. Reported overall infection prevention and control (IPC) improvement could decrease AMR rates, whereas increases in selected inappropriate IPC practices and antimicrobial prescribing could increase rates. Most did not yet have complete data on changing AMR rates due to COVID-19.\n\nThis was the first survey to explore the global impact of COVID-19 on AMR among GLASS countries. Responses highlight important actions to help ensure that AMR remains a global health priority, including engaging with GLASS to facilitate reliable AMR surveillance data, seizing the opportunity to develop more sustainable IPC programmes, promoting integrated antibiotic stewardship guidance, leveraging increased laboratory capabilities and other system-strengthening efforts.", "doi": "10.1093/jac/dkab300", "pmid": "34473285", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6362680"}], "notes": [], "created": "2021-09-06T06:09:23.666Z", "modified": "2021-09-06T06:09:23.763Z"}, {"entity": "publication", "iuid": "f83279fbc63c4980b12915cb5d036bc9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f83279fbc63c4980b12915cb5d036bc9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f83279fbc63c4980b12915cb5d036bc9"}}, "title": "Challenges in Preventive Practices and Risk Communication towards COVID-19: A Cross-Sectional Study in Bangladesh.", "authors": [{"family": "Rahman", "given": "Farah Naz", "initials": "FN", "orcid": "0000-0002-2265-2742", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35a313c259ed4fe3831ae74c581ee93e.json"}}, {"family": "Bhuiyan", "given": "Md Al Amin", "initials": "MAA", "orcid": "0000-0001-7385-0864", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af9df494efd648649fac724cf777d7d0.json"}}, {"family": "Hossen", "given": "Kabir", "initials": "K"}, {"family": "Khan", "given": "Hafiz T A", "initials": "HTA", "orcid": "0000-0002-1817-3730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b05ad34abbf241f0aa9d7cc4cf0010ac.json"}}, {"family": "Rahman", "given": "Akm Fazlur", "initials": "AF"}, {"family": "Dalal", "given": "Koustuv", "initials": "K", "orcid": "0000-0001-7393-796X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab5e44a17b7545988cb46cdf5b1f3e4e.json"}}], "type": "journal article", "published": "2021-09-02", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "17", "pages": null}, "abstract": "Bangladesh recently experienced a COVID-19 second wave, resulting in the highest number of new cases and deaths in a single day. This study aims to identify the challenges for COVID-19 preventive practices and risk communications and associated factors among Bangladeshi adults. A cross-sectional survey was conducted between December 2020 and January 2021 involving 1382 Bangladeshi adults (aged \u2265 18-years) in randomly selected urban and rural areas from all eight divisions in Bangladesh. Descriptive data analysis was conducted to highlight the challenges for preventive practices and risk communications for COVID-19. Multiple logistic regression analysis was used to determine the sociodemographic groups vulnerable to these challenges. Lack of availability of protective equipment (44.4%), crowded living situations/workspaces (36.8%), inadequate information on the proper use of protective measures (21.9%), inadequate handwashing and sanitation facilities (17.6%), and negative influences on family/friends (17.4%) were identified as barriers to COVID-19 preventive practices. It was also found that males (OR = 1.3, 95% CI = 1.01, 1.7), rural residents (OR = 1.5, 95% CI = 1.2, 2), respondents with a low level of education: no schooling vs. \u2265higher secondary (OR = 3.5, 95% CI = 2.3, 5.2), primary vs. \u2265higher secondary (OR = 2.5, 95% CI = 1.7, 3.8), respondents engaged in agricultural (OR = 1.7, 95% CI = 1.2, 2.4), laboring (OR = 3.2, 95% CI = 2, 5), and domestic works (OR = 1.6, 95% CI = 1.07, 2.5), and people with disabilities (OR = 1.7, 95% CI = 1.1, 2.6) were all likely to have difficulty in practicing effective COVID-19 protective behaviors. Respondents' education and occupation were significant predictors of inadequate understanding of COVID-19 risk communications and was identified as a problem among 17.4% of the respondents. A substantial percentage of Bangladeshi adults have difficulty practising COVID-19 protective behaviours and have poor comprehension of risk communications, particularly in rural areas and among those with low education. This research can aid policymakers in developing tailored COVID-19 risk communications and mitigation strategies to help prevent future waves of the pandemic.", "doi": "10.3390/ijerph18179259", "pmid": "34501847", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph18179259"}], "notes": [], "created": "2021-09-13T06:24:36.671Z", "modified": "2021-11-18T14:03:05.334Z"}, {"entity": "publication", "iuid": "fc8723392b684de496dd9cd342b7d8d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc8723392b684de496dd9cd342b7d8d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc8723392b684de496dd9cd342b7d8d0"}}, "title": "Association of cardiometabolic risk factors with hospitalisation or death due to COVID-19: population-based cohort study in Sweden (SCAPIS).", "authors": [{"family": "Tornhammar", "given": "Per", "initials": "P"}, {"family": "Jernberg", "given": "Tomas", "initials": "T"}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G"}, {"family": "Blomberg", "given": "Anders", "initials": "A"}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G"}, {"family": "Engvall", "given": "Jan", "initials": "J"}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f34c0d3602439abe6096293c7c732d.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Janson", "given": "Christer", "initials": "C", "orcid": "0000-0001-5093-6980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba296cda8ef74430ad5457e71b7dae94.json"}}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Sk\u00f6ld", "given": "C Magnus", "initials": "CM"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "S\u00f6derberg", "given": "Stefan", "initials": "S", "orcid": "0000-0001-9225-1306", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac9507251cd84369a92d7f552d65f79e.json"}}, {"family": "Zaigham", "given": "Suneela", "initials": "S"}, {"family": "\u00d6stgren", "given": "Carl Johan", "initials": "CJ"}, {"family": "Andersson", "given": "Daniel Peter", "initials": "DP", "orcid": "0000-0003-4655-4837", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e35f15e626c045c191bd14a522a85c0e.json"}}, {"family": "Ueda", "given": "Peter", "initials": "P", "orcid": "0000-0002-3275-8743", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b5966168cb44c01b62e46aed9c8a02c.json"}}], "type": "journal article", "published": "2021-09-02", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "9", "pages": "e051359"}, "abstract": "To assess the association of cardiometabolic risk factors with hospitalisation or death due to COVID-19 in the general population.\r\n\r\nSwedish population-based cohort including 29 955 participants.\r\n\r\nCardiometabolic risk factors assessed between 2014 and 2018.\r\n\r\nHospitalisation or death due to COVID-19, as registered in nationwide registers from 31 January 2020 through 12 September 2020. Associations of cardiometabolic risk factors with the outcome were assessed using logistic regression adjusted for age, sex, birthplace and education.\r\n\r\nMean (SD) age was 61.2 (4.5) and 51.5% were women. 69 participants experienced hospitalisation or death due to COVID-19. Examples of statistically significant associations between baseline factors and subsequent hospitalisation or death due to COVID-19 included overweight (adjusted OR (aOR) vs normal weight 2.73 (95% CI 1.25 to 5.94)), obesity (aOR vs normal weight 4.09 (95% CI 1.82 to 9.18)), pre-diabetes (aOR vs normoglycaemia 2.56 (95% CI 1.44 to 4.55)), diabetes (aOR vs normoglycaemia 3.96 (95% CI 2.13 to 7.36)), sedentary time (aOR per hour/day increase 1.10 (95% CI 1.02 to 1.17)), grade 2 hypertension (aOR vs normotension 2.44 (95% CI 1.10 to 5.44)) and high density lipoprotein cholesterol (aOR per mmol/L increase 0.33 (95% CI 0.17 to 0.65)). Statistically significant associations were not observed for grade 1 hypertension (aOR vs normotension 1.03 (95% CI 0.55 to 1.96)), current smoking (aOR 0.56 (95% CI 0.24 to 1.30)), total cholesterol (aOR per mmol/L increase 0.90 (95% CI 0.71 to 1.13)), low density lipoprotein cholesterol (aOR per mmol/L increase 0.90 (95% CI 0.69 to 1.15)) and coronary artery calcium score (aOR per 10 units increase 1.00 (95% CI 0.99 to 1.01)).\r\n\r\nIn a large population-based sample from the general population, several cardiometabolic risk factors were associated with hospitalisation or death due to COVID-19.", "doi": "10.1136/bmjopen-2021-051359", "pmid": "34475186", "labels": {"Funder: Hj\u00e4rt-Lungfonden": null, "Funder: Vinnova": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-051359"}, {"db": "pmc", "key": "PMC8413466"}], "notes": [], "created": "2021-09-06T06:01:30.773Z", "modified": "2022-02-08T19:27:17.375Z"}, {"entity": "publication", "iuid": "8b8a1eaec13f4f0ea95e51be6748dd97", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b8a1eaec13f4f0ea95e51be6748dd97.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b8a1eaec13f4f0ea95e51be6748dd97"}}, "title": "Iodide supplementation of the anti-viral duox-lactoperoxidase activity may prevent some SARS-CoV-2 infections.", "authors": [{"family": "Smith", "given": "Michael L", "initials": "ML", "orcid": "0000-0003-4103-8614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4c9b76424464a188d2880c45a0f4303.json"}}, {"family": "Sharma", "given": "Sujata", "initials": "S"}, {"family": "Singh", "given": "Tej P", "initials": "TP", "orcid": "0000-0002-2886-7963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4aa57530849449bb3fd877de0182529.json"}}], "type": "letter", "published": "2021-09-01", "journal": {"title": "Eur J Clin Nutr", "issn": "1476-5640", "issn-l": null}, "abstract": null, "doi": "10.1038/s41430-021-00995-2", "pmid": "34471253", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41430-021-00995-2"}, {"db": "pmc", "key": "PMC8408568"}], "notes": [], "created": "2021-09-06T06:15:56.793Z", "modified": "2021-09-06T06:15:56.866Z"}, {"entity": "publication", "iuid": "1122b9f54daf4494987a99f1daf28185", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1122b9f54daf4494987a99f1daf28185.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1122b9f54daf4494987a99f1daf28185"}}, "title": "Distinct Metabolic Profile Associated with a Fatal Outcome in COVID-19 Patients during the Early Epidemic in Italy.", "authors": [{"family": "Saccon", "given": "Elisa", "initials": "E"}, {"family": "Bandera", "given": "Alessandra", "initials": "A", "orcid": "0000-0001-9440-4601", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5fc84c1fbbf42d1bba7d98ae000b3b0.json"}}, {"family": "Scium\u00e8", "given": "Mariarita", "initials": "M"}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "Lashari", "given": "Abid A", "initials": "AA"}, {"family": "Aliberti", "given": "Stefano", "initials": "S"}, {"family": "Sachs", "given": "Michael C", "initials": "MC"}, {"family": "Billi", "given": "Filippo", "initials": "F"}, {"family": "Blasi", "given": "Francesco", "initials": "F"}, {"family": "Gabriel", "given": "Erin E", "initials": "EE"}, {"family": "Costantino", "given": "Giorgio", "initials": "G"}, {"family": "De Roberto", "given": "Pasquale", "initials": "P"}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Gori", "given": "Andrea", "initials": "A"}, {"family": "Peyvandi", "given": "Flora", "initials": "F"}, {"family": "Scudeller", "given": "Luigia", "initials": "L", "orcid": "0000-0001-7240-9567", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09948bf33c1e40a294d256f8b905f117.json"}}, {"family": "Canetta", "given": "Ciro", "initials": "C"}, {"family": "Lorson", "given": "Christian L", "initials": "CL"}, {"family": "Valenti", "given": "Luca", "initials": "L"}, {"family": "Singh", "given": "Kamal", "initials": "K"}, {"family": "Baldini", "given": "Luca", "initials": "L"}, {"family": "Fracchiolla", "given": "Nicola Stefano", "initials": "NS"}, {"family": "COVID-19 Network Working Group,", "given": "", "initials": ""}, {"family": "Neogi", "given": "Ujjwal", "initials": "U", "orcid": "0000-0002-0844-3338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5c27a627463945d992d74005f8a60d88.json"}}], "type": "journal article", "published": "2021-09-01", "journal": {"title": "Microbiol Spectr", "issn": "2165-0497", "pages": "e0054921", "issn-l": null}, "abstract": "In one year of the coronavirus disease 2019 (COVID-19) pandemic, many studies have described the different metabolic changes occurring in COVID-19 patients, linking these alterations to the disease severity. However, a complete metabolic signature of the most severe cases, especially those with a fatal outcome, is still missing. Our study retrospectively analyzes the metabolome profiles of 75 COVID-19 patients with moderate and severe symptoms admitted to Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Lombardy Region, Italy) following SARS-CoV-2 infection between March and April 2020. Italy was the first Western country to experience COVID-19, and the Lombardy Region was the epicenter of the Italian COVID-19 pandemic. This cohort shows a higher mortality rate compared to others; therefore, it represents a unique opportunity to investigate the underlying metabolic profiles of the first COVID-19 patients in Italy and to identify the potential biomarkers related to the disease prognosis and fatal outcome. IMPORTANCE Understanding the metabolic alterations occurring during an infection is a key element for identifying potential indicators of the disease prognosis, which are fundamental for developing efficient diagnostic tools and offering the best therapeutic treatment to the patient. Here, exploiting high-throughput metabolomics data, we identified the first metabolic profile associated with a fatal outcome, not correlated with preexisting clinical conditions or the oxygen demand at the moment of diagnosis. Overall, our results contribute to a better understanding of COVID-19-related metabolic disruption and may represent a useful starting point for the identification of independent prognostic factors to be employed in therapeutic practice.", "doi": "10.1128/Spectrum.00549-21", "pmid": "34468185", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: VR": null}, "xrefs": [], "notes": [], "created": "2021-09-06T06:20:28.618Z", "modified": "2021-10-10T15:12:11.738Z"}, {"entity": "publication", "iuid": "e3844727d8014bef83b79b9022d2dbd8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3844727d8014bef83b79b9022d2dbd8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3844727d8014bef83b79b9022d2dbd8"}}, "title": "Active matrix metalloproteinase-8 (aMMP-8) point-of-care test (POCT) in the COVID-19 pandemic.", "authors": [{"family": "Sorsa", "given": "Timo", "initials": "T"}, {"family": "Sahni", "given": "Vaibhav", "initials": "V"}, {"family": "Buduneli", "given": "Nurcan", "initials": "N"}, {"family": "Gupta", "given": "Shipra", "initials": "S"}, {"family": "R\u00e4is\u00e4nen", "given": "Ismo T", "initials": "IT", "orcid": "0000-0001-5821-5299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5688183e182e4194888dc98301077bab.json"}}, {"family": "Golub", "given": "Lorne M", "initials": "LM"}, {"family": "Lee", "given": "Hsi-Ming", "initials": "HM"}, {"family": "P\u00e4til\u00e4", "given": "Tommi", "initials": "T"}, {"family": "Bostanci", "given": "Nagihan", "initials": "N"}, {"family": "Meurman", "given": "Jukka", "initials": "J", "orcid": "0000-0001-6702-6836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ebb40fd79c04c618b3ae2908a70d317.json"}}, {"family": "P\u00e4rn\u00e4nen", "given": "Pirjo", "initials": "P"}, {"family": "Nwhator", "given": "Solomon O", "initials": "SO"}, {"family": "Singla", "given": "Mohita", "initials": "M"}, {"family": "Gauba", "given": "Krishan", "initials": "K"}], "type": "journal article", "published": "2021-09-01", "journal": {"title": "Expert Rev Proteomics", "issn": "1744-8387", "issn-l": null}, "abstract": "Active matrix metalloproteinase (aMMP)-8 utilized in point-of-care testing (POCT) is regarded as a potential biomarker for periodontal and peri-implant diseases. Various host and microbial factors eventually influence the expression, degranulation, levels and activation of aMMP-8. The type of oral fluids (saliva, mouthrinse, gingival crevicular and peri-implant sulcular fluids [GCF/PISF], respectively) affect the analysis.\n\nWith this background, we aimed to review here the recent studies on practical, inexpensive, noninvasive and quantitative mouthrinse and GCF/PISF chair-side POCT lateral flow aMMP-8 immunoassays (PerioSafe and ImplantSafe/ORALyzer) and how they help to detect, predict, monitor the course, treatment and prevention of periodontitis and peri-implantitis. The correlations of aMMP-8 POCT to other independent and catalytic activity assays of MMP-8 are also addressed.\n\nThe mouthrinse aMMP-8 POCT can also detect prediabetes/diabetes and tissue destructive oral side-effects due to the head and neck cancers' radiotherapy. Chlorhexidine and doxycycline can inhibit collagenolytic human neutrophil and GCF aMMP-8. Furthermore, by a set of case-series we demonstrate the potential of mouthrinse aMMP-8 POCT to real-time/online detect periodontitis as a potential risk disease for coronavirus disease 2019 (COVID-19). The clinical interdisciplinary utilization of aMMP-8 POCT requires additional oral, medical and interdisciplinary studies.", "doi": "10.1080/14789450.2021.1976151", "pmid": "34468272", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-09-06T06:20:03.652Z", "modified": "2021-09-06T06:20:03.727Z"}, {"entity": "publication", "iuid": "d462e8f607604abbbff7f19df78740fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d462e8f607604abbbff7f19df78740fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d462e8f607604abbbff7f19df78740fc"}}, "title": "Vaccine effectiveness against infection with the Delta (B.1.617.2) variant, Norway, April to August 2021.", "authors": [{"family": "Sepp\u00e4l\u00e4", "given": "Elina", "initials": "E"}, {"family": "Veneti", "given": "Lamprini", "initials": "L"}, {"family": "Starrfelt", "given": "Jostein", "initials": "J"}, {"family": "Danielsen", "given": "Anders Skyrud", "initials": "AS"}, {"family": "Bragstad", "given": "Karoline", "initials": "K"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "Taxt", "given": "Arne Michael", "initials": "AM"}, {"family": "Watle", "given": "Sara Viksmoen", "initials": "SV"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "35", "pages": null}, "abstract": "Some variants of SARS-CoV-2 are associated with increased transmissibility, increased disease severity or decreased vaccine effectiveness (VE). In this population-based cohort study (n = 4,204,859), the Delta variant was identified in 5,430 (0.13%) individuals, of whom 84 were admitted to hospital. VE against laboratory confirmed infection with the Delta variant was 22.4% among partly vaccinated (95% confidence interval (CI): 17.0-27.4) and 64.6% (95% CI: 60.6-68.2) among fully vaccinated individuals, compared with 54.5% (95% CI: 50.4-58.3) and 84.4% (95%CI: 81.8-86.5) against the Alpha variant.", "doi": "10.2807/1560-7917.ES.2021.26.35.2100793", "pmid": "34477054", "labels": {"Category: Genomics & transcriptomics": null, "Category: Drug Discovery": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-09-06T05:53:34.921Z", "modified": "2021-11-29T06:15:04.418Z"}, {"entity": "publication", "iuid": "45a576151c394ef38702a583f1654699", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/45a576151c394ef38702a583f1654699.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/45a576151c394ef38702a583f1654699"}}, "title": "Unequal Labour Market Impacts of COVID-19 in Sweden \u2014 But Not Between Women and Men", "authors": [{"family": "Campa", "given": "Pamela", "initials": "P"}, {"family": "Roine", "given": "Jesper", "initials": "J"}, {"family": "Str\u00f6mberg", "given": "Svante", "initials": "S"}], "type": "journal-article", "published": "2021-09-00", "journal": {"title": "Intereconomics", "issn": "0020-5346", "issn-l": null, "volume": "56", "issue": "5", "pages": "264-269"}, "abstract": null, "doi": "10.1007/s10272-021-0996-3", "pmid": null, "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:52:36.938Z", "modified": "2022-11-23T08:52:04.923Z"}, {"entity": "publication", "iuid": "a0b638ade2174bf6ad9cea1ba3806e93", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a0b638ade2174bf6ad9cea1ba3806e93.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a0b638ade2174bf6ad9cea1ba3806e93"}}, "title": "Trust in the government increases financial well-being and general well-being during COVID-19.", "authors": [{"family": "Barrafrem", "given": "Kinga", "initials": "K"}, {"family": "Tingh\u00f6g", "given": "Gustav", "initials": "G"}, {"family": "V\u00e4stfj\u00e4ll", "given": "Daniel", "initials": "D"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "J Behav Exp Finance", "issn": "2214-6350", "issn-l": null, "volume": "31", "issue": null, "pages": "100514"}, "abstract": "We investigate the antecedents of subjective financial well-being and general well-being during the ongoing COVID-19 pandemic. In an online survey conducted in the midst of COVID-19 pandemic with over 1000 Swedish participants we found that distrust in the government to cope with financial (but not healthcare) challenges of the pandemic was negatively related to the feeling of financial security. In a structural equation model, we also show that trust in government to deal with financial challenges of COVID-19 pandemic has a significant impact on general well-being through the mediating channel of financial well-being. In addition, trust in government to deal with healthcare challenges of COVID-19 pandemic has a significant direct impact on individuals' general well-being. Our findings have important implications for public policy as they highlight the importance of citizens' trust in well-functioning governmental institutions to help cope with not only healthcare, but also financial challenges of an ongoing pandemic.", "doi": "10.1016/j.jbef.2021.100514", "pmid": "34545323", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2214-6350(21)00058-7"}, {"db": "pmc", "key": "PMC8444950"}], "notes": [], "created": "2021-10-27T05:11:02.378Z", "modified": "2021-11-18T14:01:18.560Z"}, {"entity": "publication", "iuid": "bf72161a487f403ab690c95bc4b98b16", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf72161a487f403ab690c95bc4b98b16.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf72161a487f403ab690c95bc4b98b16"}}, "title": "Thirty-Day Outcomes of Children and Adolescents With COVID-19: An International Experience.", "authors": [{"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "Vizcaya", "given": "David", "initials": "D"}, {"family": "Pistillo", "given": "Andrea", "initials": "A"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Lai", "given": "Lana Yin Hui", "initials": "LYH"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A"}, {"family": "Ahmed", "given": "Waheed-Ul-Rahman", "initials": "WU"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Burn", "given": "Edward", "initials": "E"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Blacketer", "given": "Clair", "initials": "C"}, {"family": "DuVall", "given": "Scott", "initials": "S"}, {"family": "Falconer", "given": "Thomas", "initials": "T"}, {"family": "Fernandez-Bertolin", "given": "Sergio", "initials": "S"}, {"family": "Fortin", "given": "Stephen", "initials": "S"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Gong", "given": "Mengchun", "initials": "M"}, {"family": "Tan", "given": "Eng Hooi", "initials": "EH"}, {"family": "Huser", "given": "Vojtech", "initials": "V"}, {"family": "Iveli", "given": "Pablo", "initials": "P"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Recalde", "given": "Martina", "initials": "M"}, {"family": "Roel", "given": "Elena", "initials": "E"}, {"family": "Schilling", "given": "Lisa M", "initials": "LM"}, {"family": "Shah", "given": "Nigam H", "initials": "NH"}, {"family": "Shah", "given": "Karishma", "initials": "K"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhang", "given": "Ying", "initials": "Y"}, {"family": "Williams", "given": "Andrew E", "initials": "AE"}, {"family": "Reich", "given": "Christian G", "initials": "CG"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Rijnbeek", "given": "Peter", "initials": "P"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}], "type": "comparative study", "published": "2021-09-00", "journal": {"title": "Pediatrics", "issn": "1098-4275", "volume": "148", "issue": "3", "pages": "e2020042929", "issn-l": null}, "abstract": "To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children and adolescents diagnosed or hospitalized with coronavirus disease 2019 (COVID-19) and to compare them in secondary analyses with patients diagnosed with previous seasonal influenza in 2017-2018.\n\nInternational network cohort using real-world data from European primary care records (France, Germany, and Spain), South Korean claims and US claims, and hospital databases. We included children and adolescents diagnosed and/or hospitalized with COVID-19 at age <18 between January and June 2020. We described baseline demographics, comorbidities, symptoms, 30-day in-hospital treatments, and outcomes including hospitalization, pneumonia, acute respiratory distress syndrome, multisystem inflammatory syndrome in children, and death.\n\nA total of 242 158 children and adolescents diagnosed and 9769 hospitalized with COVID-19 and 2 084 180 diagnosed with influenza were studied. Comorbidities including neurodevelopmental disorders, heart disease, and cancer were more common among those hospitalized with versus diagnosed with COVID-19. Dyspnea, bronchiolitis, anosmia, and gastrointestinal symptoms were more common in COVID-19 than influenza. In-hospital prevalent treatments for COVID-19 included repurposed medications (<10%) and adjunctive therapies: systemic corticosteroids (6.8%-7.6%), famotidine (9.0%-28.1%), and antithrombotics such as aspirin (2.0%-21.4%), heparin (2.2%-18.1%), and enoxaparin (2.8%-14.8%). Hospitalization was observed in 0.3% to 1.3% of the cohort diagnosed with COVID-19, with undetectable (n < 5 per database) 30-day fatality. Thirty-day outcomes including pneumonia and hypoxemia were more frequent in COVID-19 than influenza.\n\nDespite negligible fatality, complications including hospitalization, hypoxemia, and pneumonia were more frequent in children and adolescents with COVID-19 than with influenza. Dyspnea, anosmia, and gastrointestinal symptoms could help differentiate diagnoses. A wide range of medications was used for the inpatient management of pediatric COVID-19.", "doi": "10.1542/peds.2020-042929", "pmid": "34049958", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "peds.2020-042929"}], "notes": [], "created": "2021-06-04T11:38:07.570Z", "modified": "2023-06-19T15:35:04.313Z"}, {"entity": "publication", "iuid": "5f6e4c6729a14595bd3010f6bcb6218f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f6e4c6729a14595bd3010f6bcb6218f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f6e4c6729a14595bd3010f6bcb6218f"}}, "title": "The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages", "authors": [{"family": "Martin", "given": "Darren P", "initials": "DP"}, {"family": "Weaver", "given": "Steven", "initials": "S", "orcid": "0000-0002-6931-7191", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b28e228830204c0787e6e291c5504314.json"}}, {"family": "Tegally", "given": "Houriiyah", "initials": "H"}, {"family": "San", "given": "James Emmanuel", "initials": "JE", "orcid": "0000-0002-5736-664X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5229990d46874a5185d136b09fce716a.json"}}, {"family": "Shank", "given": "Stephen D", "initials": "SD"}, {"family": "Wilkinson", "given": "Eduan", "initials": "E"}, {"family": "Lucaci", "given": "Alexander G", "initials": "AG"}, {"family": "Giandhari", "given": "Jennifer", "initials": "J"}, {"family": "Naidoo", "given": "Sureshnee", "initials": "S"}, {"family": "Pillay", "given": "Yeshnee", "initials": "Y"}, {"family": "Singh", "given": "Lavanya", "initials": "L", "orcid": "0000-0002-1726-4454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bbfb5df3bc34277aa004bfcf9a3775b.json"}}, {"family": "Lessells", "given": "Richard J", "initials": "RJ"}, {"family": "Gupta", "given": "Ravindra K", "initials": "RK"}, {"family": "Wertheim", "given": "Joel O", "initials": "JO"}, {"family": "Nekturenko", "given": "Anton", "initials": "A"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Harkins", "given": "Gordon W", "initials": "GW"}, {"family": "Lemey", "given": "Philippe", "initials": "P"}, {"family": "MacLean", "given": "Oscar A", "initials": "OA"}, {"family": "Robertson", "given": "David L", "initials": "DL"}, {"family": "de Oliveira", "given": "Tulio", "initials": "T", "orcid": "0000-0002-3027-5254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3dadcb78141a496ba76769d69667bf79.json"}}, {"family": "Kosakovsky Pond", "given": "Sergei L", "initials": "SL"}], "type": "journal-article", "published": "2021-09-00", "journal": {"title": "Cell", "issn": "0092-8674", "issn-l": null}, "abstract": "The independent emergence late in 2020 of the B.1.1.7, B.1.351, and P.1 lineages of SARS-CoV-2 prompted renewed concerns about the evolutionary capacity of this virus to overcome public health interventions and rising population immunity. Here, by examining patterns of synonymous and non-synonymous mutations that have accumulated in SARS-CoV-2 genomes since the pandemic began, we find that the emergence of these three \"501Y lineages\" coincided with a major global shift in the selective forces acting on various SARS-CoV-2 genes. Following their emergence, the adaptive evolution of 501Y lineage viruses has involved repeated selectively favored convergent mutations at 35 genome sites, mutations we refer to as the 501Y meta-signature. The ongoing convergence of viruses in many other lineages on this meta-signature suggests that it includes multiple mutation combinations capable of promoting the persistence of diverse SARS-CoV-2 lineages in the face of mounting host immune recognition.", "doi": "10.1016/j.cell.2021.09.003", "pmid": "34537136", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0092-8674(21)01050-3"}, {"db": "pmc", "key": "PMC8421097"}, {"db": "URL", "key": "https://doi.org/10.5281/zenodo.5149112", "description": "Initial release of SARS-CoV2 variation data"}, {"db": "URL", "key": "https://observablehq.com/@spond/n501y-clades@3752", "description": "Visualizing selection analysis results for evolution of the B.1.351 clade"}, {"db": "URL", "key": "https://observablehq.com/@spond/sc2-selection-trends", "description": "Frequency trends and selection detection of subsets of sites in SARS-CoV-2 genes"}, {"db": "URL", "key": "https://observablehq.com/@spond/sc2-temporal-selection-trends", "description": "Temporal evolution of selective pressures on SARS-CoV-2 genes"}, {"db": "URL", "key": "https://github.com/spond/SARS-CoV-2-clade-analysis", "description": "Collection of result files and underlying sequence alignments processed by the RASCL SARS-CoV-2 clade analysis pipeline"}], "notes": [], "created": "2021-09-20T16:58:24.660Z", "modified": "2021-10-15T07:50:25.330Z"}, {"entity": "publication", "iuid": "a95b2d52208f4df0b81429ca74ff612c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a95b2d52208f4df0b81429ca74ff612c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a95b2d52208f4df0b81429ca74ff612c"}}, "title": "Socioeconomic patterns and COVID-19 outcomes before, during and after the lockdown in Italy (2020).", "authors": [{"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Rosano", "given": "Aldo", "initials": "A"}, {"family": "Vescio", "given": "Maria Fenicia", "initials": "MF"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Regidor", "given": "Enrique", "initials": "E"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Health Place", "issn": "1873-2054", "issn-l": null, "volume": "71", "issue": null, "pages": "102642"}, "abstract": "The objective was to investigate the association between deprivation and COVID-19 outcomes in Italy during pre-lockdown, lockdown and post-lockdown periods using a retrospective cohort study with 38,534,169 citizens and 222,875 COVID-19 cases. Multilevel negative binomial regression models, adjusting for age, sex, population-density and region of residence were conducted to evaluate the association between area-level deprivation and COVID-19 incidence, case-hospitalisation rate and case-fatality. During lockdown and post-lockdown, but not during pre-lockdown, higher incidence of cases was observed in the most deprived municipalities compared with the least deprived ones. No differences in case-hospitalisation and case-fatality according to deprivation were observed in any period under study.", "doi": "10.1016/j.healthplace.2021.102642", "pmid": "34339938", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1353-8292(21)00138-6"}, {"db": "pmc", "key": "PMC8318679"}], "notes": [], "created": "2021-08-04T10:11:02.697Z", "modified": "2021-11-18T12:43:33.213Z"}, {"entity": "publication", "iuid": "cad7e895541f4af7a873cdfaf3742488", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cad7e895541f4af7a873cdfaf3742488.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cad7e895541f4af7a873cdfaf3742488"}}, "title": "Severe features during outbreak but low mortality observed immediately before and after a March-May 2020 COVID-19 outbreak in Stockholm, Sweden.", "authors": [{"family": "Pimenoff", "given": "Ville N", "initials": "VN"}, {"family": "Bj\u00f6rnstedt", "given": "Mikael", "initials": "M"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": "110", "issue": null, "pages": "433-435"}, "abstract": "The aim of this study was to estimate how well the excess mortality reflected the burden of coronavirus disease 2019 (COVID-19)-related deaths during the March-May 2020 COVID-19 outbreak in Stockholm, Sweden, and whether the excess mortality during the outbreak might have resulted in a compensatory reduced mortality after the outbreak.\n\nUsing previous 10-year or 5-year average mortality rates as a baseline, the excess mortality estimates before, during, and after the COVID-19 outbreak in March-May 2020 in Stockholm were compared.\n\nWeekly death estimates revealed that the immediate pre-outbreak and post-outbreak all-cause mortality did not exceed to excess mortality regardless of whether previous 10-year or 5-year average mortality was used. Forty-three days after the start of the outbreak, 74.4% of the total excess mortality was reportedly explained by known COVID-19-related deaths, and the present study reports an update, showing that 15 weeks after the start of the outbreak, the reported COVID-19-related deaths explained >99% of the total excess mortality.\n\nAn exceptional outbreak feature of rapid excess mortality was observed. However, no excess but similarly low mortality was observed immediately prior to the outbreak and post-outbreak, thus emphasizing the severity of the first wave of the COVID-19 outbreak in Stockholm.", "doi": "10.1016/j.ijid.2021.08.005", "pmid": "34375761", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)00637-8"}, {"db": "pmc", "key": "PMC8349439"}], "notes": [], "created": "2021-08-11T14:26:46.302Z", "modified": "2021-11-18T13:29:36.379Z"}, {"entity": "publication", "iuid": "b03b9a4143de4683b96849ba0bfa5111", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b03b9a4143de4683b96849ba0bfa5111.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b03b9a4143de4683b96849ba0bfa5111"}}, "title": "Risk of severe COVID-19 infection in International Space Station astronauts despite routine pre-mission measures.", "authors": [{"family": "Javad Mortazavi", "given": "Seyed Mohammad", "initials": "SM"}, {"family": "Mortazavi", "given": "Seyed Alireza", "initials": "SA"}, {"family": "Sihver", "given": "Lembit", "initials": "L"}], "type": "letter", "published": "2021-09-00", "journal": {"title": "J Allergy Clin Immunol Pract", "issn": "2213-2201", "volume": "9", "issue": "9", "pages": "3527", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jaip.2021.05.043", "pmid": "34507714", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-2198(21)00700-5"}], "notes": [], "created": "2021-09-13T06:26:57.018Z", "modified": "2021-09-13T06:26:57.029Z"}, {"entity": "publication", "iuid": "4695e8c834724f698d86079fff003688", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4695e8c834724f698d86079fff003688.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4695e8c834724f698d86079fff003688"}}, "title": "Rapid policy development for essential RMNCAH services in sub-Saharan Africa: what happened during the COVID-19 pandemic and what needs to happen going forward?", "authors": [{"family": "Waiswa", "given": "Peter", "initials": "P"}, {"family": "Wanduru", "given": "Phillip", "initials": "P", "orcid": "0000-0001-5934-2505", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/964f6d1176b747c7a00ea484da84d763.json"}}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "9", "issn-l": "2059-7908"}, "abstract": null, "doi": "10.1136/bmjgh-2021-006938", "pmid": "34526322", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-006938"}], "notes": [], "created": "2021-09-20T16:25:22.680Z", "modified": "2021-09-20T16:26:08.136Z"}, {"entity": "publication", "iuid": "5f788fe67f124e149aa2acc87db98309", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f788fe67f124e149aa2acc87db98309.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f788fe67f124e149aa2acc87db98309"}}, "title": "Prolonged Effects of the COVID-19 Pandemic on Sleep Medicine Services-Longitudinal Data from the Swedish Sleep Apnea Registry.", "authors": [{"family": "Grote", "given": "Ludger", "initials": "L"}, {"family": "Theorell-Hagl\u00f6w", "given": "Jenny", "initials": "J"}, {"family": "Ulander", "given": "Martin", "initials": "M"}, {"family": "Hedner", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Sleep Med Clin", "issn": "1556-4088", "volume": "16", "issue": "3", "pages": "409-416", "issn-l": null}, "abstract": "The worldwide COVID-19 pandemic has affected the operation of health care systems. The direct impact of obstructive sleep apnea (OSA) on COVID-19 infection outcome remains to be elucidated. However, the coincidence of common risk factors for OSA and severe COVID-19 suggests that patients with OSA receiving positive airway pressure therapy may have an advantage relative to those untreated when confronted with a COVID-19 infection. The ongoing COVID-19 pandemic has led to a substantial reduction of sleep medicine services, and the long-term consequences may be considerable. New strategies for the management of sleep disorders are needed to overcome the current underdiagnosis and delay of treatment.", "doi": "10.1016/j.jsmc.2021.05.008", "pmid": "34325820", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1556-407X(21)00037-0"}, {"db": "pmc", "key": "PMC8258548"}], "notes": [], "created": "2021-08-04T17:06:04.153Z", "modified": "2021-08-04T17:06:05.747Z"}, {"entity": "publication", "iuid": "24858b2248dd4d2fb059a4a6d3bbd9b7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24858b2248dd4d2fb059a4a6d3bbd9b7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24858b2248dd4d2fb059a4a6d3bbd9b7"}}, "title": "Persistent symptoms in Swedish children after hospitalisation due to COVID-19.", "authors": [{"family": "Sterky", "given": "Ellinor", "initials": "E", "orcid": "0000-0003-3375-133X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8391aeb720cb4ebba5786f3a36ea4412.json"}}, {"family": "Olsson-\u00c5kefeldt", "given": "Selma", "initials": "S", "orcid": "0000-0002-9429-4163", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cdc01b4c2be3486d93d3d7126f6bb78f.json"}}, {"family": "Hertting", "given": "Olof", "initials": "O", "orcid": "0000-0002-0813-7998", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2be33c918eb644a48c6e33d730b2482b.json"}}, {"family": "Herlenius", "given": "Eric", "initials": "E", "orcid": "0000-0002-6859-0620", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8435b38e1704191a54140c72dae0b42.json"}}, {"family": "Alfven", "given": "Tobias", "initials": "T", "orcid": "0000-0002-2328-3512", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3851560b984401780a380ab1262cd8b.json"}}, {"family": "Ryd Rinder", "given": "Malin", "initials": "M", "orcid": "0000-0002-2947-4117", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b87e79413e84d8bb0a71a16fa3975fc.json"}}, {"family": "Rhedin", "given": "Samuel", "initials": "S", "orcid": "0000-0001-5798-2875", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1ee9f85f72942ed94646ba9d15cede0.json"}}, {"family": "Hildenwall", "given": "Helena", "initials": "H", "orcid": "0000-0001-7570-9792", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b715a8b59a84c6fb25e72d6a43753e5.json"}}], "type": "letter", "published": "2021-09-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": "110", "issue": "9", "pages": "2578-2580"}, "abstract": "COVID-19 is generally mild in children1 and post-acute inflammatory conditions that are temporally associated with the virus are rare, but potentially severe. However, some children and adults experience persistent symptoms after COVID-19. 2 Long COVID has not been precisely defined, but one study reported symptoms approximately 60 days after the primary diagnosis.3 Although adult long COVID is increasingly being studied, the magnitude of persistent symptoms in children remains unclear.", "doi": "10.1111/apa.15999", "pmid": "34157167", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-28T17:56:03.366Z", "modified": "2021-08-16T14:23:57.296Z"}, {"entity": "publication", "iuid": "0349bf593ecb49c6bf12f56d3df2dc6f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0349bf593ecb49c6bf12f56d3df2dc6f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0349bf593ecb49c6bf12f56d3df2dc6f"}}, "title": "Online consultations in mental healthcare during the COVID-19 outbreak: An international survey study on professionals' motivations and perceived barriers.", "authors": [{"family": "De Witte", "given": "Nele A J", "initials": "NAJ"}, {"family": "Carlbring", "given": "Per", "initials": "P"}, {"family": "Etzelmueller", "given": "Anne", "initials": "A"}, {"family": "Nordgreen", "given": "Tine", "initials": "T"}, {"family": "Karekla", "given": "Maria", "initials": "M"}, {"family": "Haddouk", "given": "Lise", "initials": "L"}, {"family": "Belmont", "given": "Ang\u00e9lique", "initials": "A"}, {"family": "\u00d8verland", "given": "Svein", "initials": "S"}, {"family": "Abi-Habib", "given": "Rudy", "initials": "R"}, {"family": "Bernaerts", "given": "Sylvie", "initials": "S"}, {"family": "Brugnera", "given": "Agostino", "initials": "A"}, {"family": "Compare", "given": "Angelo", "initials": "A"}, {"family": "Duque", "given": "Aranzazu", "initials": "A"}, {"family": "Ebert", "given": "David Daniel", "initials": "DD"}, {"family": "Eimontas", "given": "Jonas", "initials": "J"}, {"family": "Kassianos", "given": "Angelos P", "initials": "AP"}, {"family": "Salgado", "given": "Jo\u00e3o", "initials": "J"}, {"family": "Schwerdtfeger", "given": "Andreas", "initials": "A"}, {"family": "Tohme", "given": "Pia", "initials": "P"}, {"family": "Van Assche", "given": "Eva", "initials": "E"}, {"family": "Van Daele", "given": "Tom", "initials": "T"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Internet Interv", "issn": "2214-7829", "issn-l": "2214-7829", "volume": "25", "issue": null, "pages": "100405"}, "abstract": "While the general uptake of e-mental health interventions remained low over the past years, physical distancing and lockdown measures relating to the COVID-19 pandemic created a need and demand for online consultations in only a matter of weeks.\r\n\r\nThis study investigates the uptake of online consultations provided by mental health professionals during lockdown measures in the first wave of the COVID-19 pandemic in the participating countries, with a specific focus on professionals' motivations and perceived barriers regarding online consultations.\r\n\r\nAn online survey on the use of online consultations was set up in March 2020. The Unified Theory of Acceptance and Use of Technology (UTAUT) guided the deductive qualitative analysis of the results.\r\n\r\nIn total, 2082 mental health professionals from Austria, Belgium, Cyprus, France, Germany, Italy, Lebanon, Lithuania, the Netherlands, Norway, Portugal, Spain, and Sweden were included. The results showed a high uptake of online consultations during the COVID-19 pandemic but limited previous training on this topic undergone by mental health professionals. Most professionals reported positive experiences with online consultations, but concerns about the performance of online consultations in a mental health context (e.g., in terms of relational aspects) and practical considerations (e.g., relating to privacy and security of software) appear to be major barriers that hinder implementation.\r\n\r\nThis study provides an overview of the mental health professionals' actual needs and concerns regarding the use of online consultations in order to highlight areas of possible intervention and allow the implementation of necessary governmental, educational, and instrumental support so that online consultations can become a feasible and stable option in mental healthcare.", "doi": "10.1016/j.invent.2021.100405", "pmid": "34401365", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2214-7829(21)00045-2"}, {"db": "pmc", "key": "PMC8350604"}], "notes": [], "created": "2021-08-18T07:32:00.562Z", "modified": "2021-11-18T13:57:18.398Z"}, {"entity": "publication", "iuid": "d3e60a40b96a49e48c21639c683b0aea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3e60a40b96a49e48c21639c683b0aea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3e60a40b96a49e48c21639c683b0aea"}}, "title": "Nordic responses to Covid-19: Governance and policy measures in the early phases of the pandemic", "authors": [{"family": "Saunes", "given": "Ingrid Sperre", "initials": "IS"}, {"family": "Vrangb\u00e6k", "given": "Karsten", "initials": "K"}, {"family": "Byrkjeflot", "given": "Haldor", "initials": "H"}, {"family": "Jervelund", "given": "Signe Smith", "initials": "SS"}, {"family": "Birk", "given": "Hans Okkels", "initials": "HO"}, {"family": "Tynkkynen", "given": "Liina Kaisa", "initials": "LK"}, {"family": "Keskim\u00e4ki", "given": "Ilmo", "initials": "I"}, {"family": "Sigurgeirsd\u00f3ttir", "given": "Sigurbj\u00f6rg", "initials": "S"}, {"family": "Janl\u00f6v", "given": "Nils", "initials": "N"}, {"family": "Ramsberg", "given": "Joakim", "initials": "J"}, {"family": "Hern\u00e1ndez-Quevedo", "given": "Cristina", "initials": "C"}, {"family": "Merkur", "given": "Sherry", "initials": "S"}, {"family": "Sagan", "given": "Anna", "initials": "A"}, {"family": "Karanikolos", "given": "Marina", "initials": "M"}], "type": "journal-article", "published": "2021-09-00", "journal": {"title": "Health Policy", "issn": "0168-8510", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/j.healthpol.2021.08.011", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:53:23.797Z", "modified": "2021-11-18T13:56:16.670Z"}, {"entity": "publication", "iuid": "3ffba70f864142d6b721bc583d93b2f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ffba70f864142d6b721bc583d93b2f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ffba70f864142d6b721bc583d93b2f9"}}, "title": "Lung transplant after 6 months on ECMO support for SARS-CoV-2-induced ARDS complicated by severe antibody-mediated rejection.", "authors": [{"family": "Lindstedt", "given": "Sandra", "initials": "S", "orcid": "0000-0003-4484-6473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0739b93800374fa789184d52aa753ffa.json"}}, {"family": "Grins", "given": "Edgar", "initials": "E"}, {"family": "Larsson", "given": "Hillevi", "initials": "H"}, {"family": "Nilsson", "given": "Johan", "initials": "J"}, {"family": "Akbarshahi", "given": "Hamid", "initials": "H"}, {"family": "Silva", "given": "Iran", "initials": "I"}, {"family": "Hyllen", "given": "Snejana", "initials": "S"}, {"family": "Wagner", "given": "Darcy", "initials": "D", "orcid": "0000-0003-3794-1309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a62680154e2e4ae2b7cec2c44af06c9a.json"}}, {"family": "Sj\u00f6gren", "given": "Johan", "initials": "J"}, {"family": "Hansson", "given": "Lennart", "initials": "L"}, {"family": "Ederoth", "given": "Per", "initials": "P"}, {"family": "Gustafsson", "given": "Ronny", "initials": "R"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "BMJ Open Respir Res", "issn": "2052-4439", "volume": "8", "issue": "1", "issn-l": null}, "abstract": "There have been a few reports of successful lung transplantation (LTx) in patients with SARS-CoV-2-induced acute respiratory distress syndrome (ARDS); however, all reports were with rather short follow-up. Here we present a 62-year-old man without prior lung diseases. Following SARS-CoV-2-induced ARDS and 6 months of extracorporeal membrane oxygenation, he underwent LTx. 3 months post-transplantation he developed acute hypoxia requiring emergency intubation. Chest imaging showed acute rejection, and de novo DQ8-DSA was discovered. He was treated with a high dose of corticosteroids and plasmapheresis and was extubated 4 days later, yet the de novo DQ8-DSA remained. After sessions of plasmapheresis and rituximab, the levels of de novo DQ8-DSA remained unchanged. Nine months post-transplantation the patient died of respiratory failure. We herein discuss the decision to transplant, the transplantation itself and the postoperative course with severe antibody-mediated rejection. In addition, we evaluated the histological changes of the explanted lungs and compared these with end-stage idiopathic pulmonary fibrosis tissue, where both similarities and differences are seen. With the current case experience, one might consider close monitoring regarding DSA, and gives further support that LTx should only be considered for very carefully selected patients.", "doi": "10.1136/bmjresp-2021-001036", "pmid": "34544734", "labels": {"Category: Health": null}, "xrefs": [{"db": "pii", "key": "8/1/e001036"}, {"db": "pmc", "key": "PMC8453592"}], "notes": [], "created": "2021-10-10T15:39:44.215Z", "modified": "2021-10-10T15:39:44.257Z"}, {"entity": "publication", "iuid": "9e954c97139b41d2b1149ef29da764ba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9e954c97139b41d2b1149ef29da764ba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9e954c97139b41d2b1149ef29da764ba"}}, "title": "Loop-Mediated Isothermal Amplification Detection of SARS-CoV-2 and Myriad Other Applications.", "authors": [{"family": "Moore", "given": "Keith J M", "initials": "KJM"}, {"family": "Cahill", "given": "Jeremy", "initials": "J"}, {"family": "Aidelberg", "given": "Guy", "initials": "G"}, {"family": "Aronoff", "given": "Rachel", "initials": "R"}, {"family": "Bekta\u015f", "given": "Ali", "initials": "A"}, {"family": "Bezdan", "given": "Daniela", "initials": "D"}, {"family": "Butler", "given": "Daniel J", "initials": "DJ"}, {"family": "Chittur", "given": "Sridar V", "initials": "SV"}, {"family": "Codyre", "given": "Martin", "initials": "M"}, {"family": "Federici", "given": "Fernan", "initials": "F"}, {"family": "Tanner", "given": "Nathan A", "initials": "NA"}, {"family": "Tighe", "given": "Scott W", "initials": "SW"}, {"family": "True", "given": "Randy", "initials": "R"}, {"family": "Ware", "given": "Sarah B", "initials": "SB"}, {"family": "Wyllie", "given": "Anne L", "initials": "AL"}, {"family": "Afshin", "given": "Evan E", "initials": "EE"}, {"family": "Bendesky", "given": "Andres", "initials": "A"}, {"family": "Chang", "given": "Connie B", "initials": "CB"}, {"family": "Dela Rosa", "given": "Richard", "initials": "R"}, {"family": "Elhaik", "given": "Eran", "initials": "E"}, {"family": "Erickson", "given": "David", "initials": "D"}, {"family": "Goldsborough", "given": "Andrew S", "initials": "AS"}, {"family": "Grills", "given": "George", "initials": "G"}, {"family": "Hadasch", "given": "Kathrin", "initials": "K"}, {"family": "Hayden", "given": "Andrew", "initials": "A"}, {"family": "Her", "given": "Seong-Young", "initials": "SY"}, {"family": "Karl", "given": "Julie A", "initials": "JA"}, {"family": "Kim", "given": "Chang Hee", "initials": "CH"}, {"family": "Kriegel", "given": "Alison J", "initials": "AJ"}, {"family": "Kunstman", "given": "Thomas", "initials": "T"}, {"family": "Landau", "given": "Zeph", "initials": "Z"}, {"family": "Land", "given": "Kevin", "initials": "K"}, {"family": "Langhorst", "given": "Bradley W", "initials": "BW"}, {"family": "Lindner", "given": "Ariel B", "initials": "AB"}, {"family": "Mayer", "given": "Benjamin E", "initials": "BE"}, {"family": "McLaughlin", "given": "Lee A", "initials": "LA"}, {"family": "McLaughlin", "given": "Matthew T", "initials": "MT"}, {"family": "Molloy", "given": "Jenny", "initials": "J"}, {"family": "Mozsary", "given": "Christopher", "initials": "C"}, {"family": "Nadler", "given": "Jerry L", "initials": "JL"}, {"family": "D'Silva", "given": "Melinee", "initials": "M"}, {"family": "Ng", "given": "David", "initials": "D"}, {"family": "O'Connor", "given": "David H", "initials": "DH"}, {"family": "Ongerth", "given": "Jerry E", "initials": "JE"}, {"family": "Osuolale", "given": "Olayinka", "initials": "O"}, {"family": "Pinharanda", "given": "Ana", "initials": "A"}, {"family": "Plenker", "given": "Dennis", "initials": "D"}, {"family": "Ranjan", "given": "Ravi", "initials": "R"}, {"family": "Rosbash", "given": "Michael", "initials": "M"}, {"family": "Rotem", "given": "Assaf", "initials": "A"}, {"family": "Segarra", "given": "Jacob", "initials": "J"}, {"family": "Sch\u00fcrer", "given": "Stephan", "initials": "S"}, {"family": "Sherrill-Mix", "given": "Scott", "initials": "S"}, {"family": "Solo-Gabriele", "given": "Helena", "initials": "H"}, {"family": "To", "given": "Shaina", "initials": "S"}, {"family": "Vogt", "given": "Merly C", "initials": "MC"}, {"family": "Yu", "given": "Albert D", "initials": "AD"}, {"family": "Mason", "given": "Christopher E", "initials": "CE"}, {"family": "gLAMP Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "J Biomol Tech", "issn": "1943-4731", "volume": "32", "issue": "3", "pages": "228-275", "issn-l": null}, "abstract": "As the second year of the COVID-19 pandemic begins, it remains clear that a massive increase in the ability to test for SARS-CoV-2 infections in a myriad of settings is critical to controlling the pandemic and to preparing for future outbreaks. The current gold standard for molecular diagnostics is the polymerase chain reaction (PCR), but the extraordinary and unmet demand for testing in a variety of environments means that both complementary and supplementary testing solutions are still needed. This review highlights the role that loop-mediated isothermal amplification (LAMP) has had in filling this global testing need, providing a faster and easier means of testing, and what it can do for future applications, pathogens, and the preparation for future outbreaks. This review describes the current state of the art for research of LAMP-based SARS-CoV-2 testing, as well as its implications for other pathogens and testing. The authors represent the global LAMP (gLAMP) Consortium, an international research collective, which has regularly met to share their experiences on LAMP deployment and best practices; sections are devoted to all aspects of LAMP testing, including preanalytic sample processing, target amplification, and amplicon detection, then the hardware and software required for deployment are discussed, and finally, a summary of the current regulatory landscape is provided. Included as well are a series of first-person accounts of LAMP method development and deployment. The final discussion section provides the reader with a distillation of the most validated testing methods and their paths to implementation. This review also aims to provide practical information and insight for a range of audiences: for a research audience, to help accelerate research through sharing of best practices; for an implementation audience, to help get testing up and running quickly; and for a public health, clinical, and policy audience, to help convey the breadth of the effect that LAMP methods have to offer.", "doi": "10.7171/jbt.21-3203-017", "pmid": "35136384", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8802757"}], "notes": [], "created": "2022-02-11T10:32:09.826Z", "modified": "2022-02-11T10:32:17.965Z"}, {"entity": "publication", "iuid": "85dcee06080e4aea9c86f5392da1999d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/85dcee06080e4aea9c86f5392da1999d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/85dcee06080e4aea9c86f5392da1999d"}}, "title": "Hepatitis C elimination in Sweden: Progress, challenges and opportunities for growth in the time of COVID-19.", "authors": [{"family": "Blach", "given": "Sarah", "initials": "S", "orcid": "0000-0002-9252-7576", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25f4327805304f1fb1e3a1c656968937.json"}}, {"family": "Blom\u00e9", "given": "Marianne", "initials": "M"}, {"family": "Duberg", "given": "Ann-Sofi", "initials": "AS"}, {"family": "Jerkeman", "given": "Anna", "initials": "A"}, {"family": "K\u00e5berg", "given": "Martin", "initials": "M", "orcid": "0000-0001-6643-3245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/514db56665594916b97164f5084f7496.json"}}, {"family": "Klasa", "given": "Per-Erik", "initials": "PE"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Razavi-Shearer", "given": "Devin", "initials": "D", "orcid": "0000-0003-4135-1053", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6d60126b540b49eb937bbb31d8ac45cb.json"}}, {"family": "Razavi", "given": "Homie", "initials": "H"}, {"family": "Aleman", "given": "Soo", "initials": "S", "orcid": "0000-0003-0461-4870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b0edb2db8d840989936f67047ce91de.json"}}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Liver Int", "issn": "1478-3231", "volume": "41", "issue": "9", "pages": "2024-2031", "issn-l": null}, "abstract": "In 2014, the burden of hepatitis C virus (HCV) in Sweden was evaluated, to establish a baseline and inform public health interventions. Considering the changing landscape of HCV treatment, prevention, and care, and in light of the COVID-19 pandemic, this analysis seeks to evaluate Sweden's progress towards the World Health Organization (WHO) elimination targets and identify remaining barriers.\n\nThe data used for modelling HCV transmission and disease burden in Sweden were obtained through literature review, unpublished sources and expert input. A dynamic Markov model was employed to forecast population sizes and incidence of HCV through 2030. Two scenarios ('2019 Base' and 'WHO Targets') were developed to evaluate Sweden's progress towards HCV elimination.\n\nAt the beginning of 2019, there were 29 700 (95% uncertainty interval: 19 300-33 700) viremic infections in Sweden. Under the base scenario, Sweden would achieve and exceed the WHO targets for diagnosis, treatment and liver-related death. However, new infections would decrease by less than 10%, relative to 2015. Achieving all WHO targets by 2030 would require (i) expanding harm reduction programmes to reach more than 90% of people who inject drugs (PWID) and (ii) treating 90% of HCV + PWID engaged in harm reduction programmes and \u22657% of PWID not involved in harm reduction programmes, annually by 2025.\n\nIt is of utmost importance that Sweden, and all countries, find sustainability in HCV programmes by broadening the setting and base of providers to provide stability and continuity of care during turbulent times.", "doi": "10.1111/liv.14978", "pmid": "34051065", "labels": {"Category: Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8242794"}], "notes": [], "created": "2023-01-13T14:46:38.274Z", "modified": "2023-01-13T14:46:48.471Z"}, {"entity": "publication", "iuid": "56cc843c98694345a065e7e0b108c56c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56cc843c98694345a065e7e0b108c56c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56cc843c98694345a065e7e0b108c56c"}}, "title": "Experiences and motives of retirement-aged workers during the first wave of COVID-19 in Slovenia: \"This was the first time in 40 years that I really saw spring\".", "authors": [{"family": "Bratun", "given": "Ur\u0161a", "initials": "U"}, {"family": "Asaba", "given": "Eric", "initials": "E"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "J Aging Stud", "issn": "1879-193X", "volume": "58", "pages": "100954", "issn-l": null}, "abstract": "Choosing to continue working after retirement eligibility can attract both negative and positive sentiments from the general public. Studies examining the motivations of older workers have so far been conducted in times of relative social and economic stability. However, little is known about what it means for older workers to work during a lockdown or pandemic situation. The present longitudinal study aimed to explore experiences of retirement-aged workers in Slovenia in relation to their motives for prolonged work activity amid the COVID-19 pandemic, using the theory of gerotranscendence as a theoretical framework. Nine workers were interviewed before and after the start of the pandemic. The qualitative analysis was based on 18 interviews and observations, juxtaposing two analytical methods in order to illustrate common themes across the data as well as tensions in specific situations within a narrative context. Four main themes are presented: Unchanged plans, Motive developments, Psychological preparation for retirement and Views of society. In addition, a narrative analysis is presented with a focus on self-transcending elements in some of the participants' narratives. The findings suggest that during a pandemic, older workers' individual experiences might be constructed more positively compared to other groups, especially if they develop agentic identity and pursue meaningful activities. We discuss an innovative approach to gerotranscendence, complementing this theory with concepts from occupational science to develop a clearer distinction from the now dated disengagement theory and examine the life trajectories of older workers in novel situations such as a pandemic.", "doi": "10.1016/j.jaging.2021.100954", "pmid": "34425986", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0890-4065(21)00044-X"}], "notes": [], "created": "2021-08-27T09:39:07.384Z", "modified": "2021-11-18T13:54:38.271Z"}, {"entity": "publication", "iuid": "deba1acb96974c1b9756c04ed740d482", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/deba1acb96974c1b9756c04ed740d482.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/deba1acb96974c1b9756c04ed740d482"}}, "title": "Essential Emergency and Critical Care: a consensus among global clinical experts.", "authors": [{"family": "Schell", "given": "Carl Otto", "initials": "CO", "orcid": "0000-0002-7904-1336", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a40b337b45b471d97a102c355c9d874.json"}}, {"family": "Khalid", "given": "Karima", "initials": "K"}, {"family": "Wharton-Smith", "given": "Alexandra", "initials": "A", "orcid": "0000-0001-5335-2059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40347c37da324b1ab41667d9ecd71fd5.json"}}, {"family": "Oliwa", "given": "Jacquie", "initials": "J"}, {"family": "Sawe", "given": "Hendry R", "initials": "HR", "orcid": "0000-0002-0395-5385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b51230cf1724ae98dc3b0e3f438dcb1.json"}}, {"family": "Roy", "given": "Nobhojit", "initials": "N", "orcid": "0000-0003-2022-7416", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cfd30f7c54f481986b006f34ad4a541.json"}}, {"family": "Sanga", "given": "Alex", "initials": "A"}, {"family": "Marshall", "given": "John C", "initials": "JC", "orcid": "0000-0002-7902-6291", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4584172f0eb464caff9299d93cc2b71.json"}}, {"family": "Rylance", "given": "Jamie", "initials": "J"}, {"family": "Hanson", "given": "Claudia", "initials": "C", "orcid": "0000-0001-8066-7873", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c06a2e703c840788ccdf3b2c4c972bc.json"}}, {"family": "Kayambankadzanja", "given": "Raphael K", "initials": "RK"}, {"family": "Wallis", "given": "Lee A", "initials": "LA", "orcid": "0000-0003-2711-3139", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8564386ba3be49d3a3d8282952cfabf0.json"}}, {"family": "Jirwe", "given": "Maria", "initials": "M", "orcid": "0000-0003-4570-4047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b89bcaacee5b47c4bb55ecc43a5e07f0.json"}}, {"family": "Baker", "given": "Tim", "initials": "T", "orcid": "0000-0001-8727-7018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1454fc20049b4d47865268adf16d104a.json"}}, {"family": "EECC Collaborators", "given": "", "initials": ""}, {"family": "EECC Collaborators*", "given": "", "initials": ""}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "9", "issn-l": "2059-7908"}, "abstract": "Globally, critical illness results in millions of deaths every year. Although many of these deaths are potentially preventable, the basic, life-saving care of critically ill patients are often overlooked in health systems. Essential Emergency and Critical Care (EECC) has been devised as the care that should be provided to all critically ill patients in all hospitals in the world. EECC includes the effective care of low cost and low complexity for the identification and treatment of critically ill patients across all medical specialties. This study aimed to specify the content of EECC and additionally, given the surge of critical illness in the ongoing pandemic, the essential diagnosis-specific care for critically ill patients with COVID-19.\n\nIn a Delphi process, consensus (>90% agreement) was sought from a diverse panel of global clinical experts. The panel iteratively rated proposed treatments and actions based on previous guidelines and the WHO/ICRC's Basic Emergency Care. The output from the Delphi was adapted iteratively with specialist reviewers into a coherent and feasible package of clinical processes plus a list of hospital readiness requirements.\n\nThe 269 experts in the Delphi panel had clinical experience in different acute medical specialties from 59 countries and from all resource settings. The agreed EECC package contains 40 clinical processes and 67 requirements, plus additions specific for COVID-19.\n\nThe study has specified the content of care that should be provided to all critically ill patients. Implementing EECC could be an effective strategy for policy makers to reduce preventable deaths worldwide.", "doi": "10.1136/bmjgh-2021-006585", "pmid": "34548380", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-006585"}, {"db": "pmc", "key": "PMC8458367"}], "notes": [], "created": "2021-10-27T05:12:13.486Z", "modified": "2021-10-27T05:12:13.770Z"}, {"entity": "publication", "iuid": "81e107e78c0f4c01abbe63f378d1c489", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/81e107e78c0f4c01abbe63f378d1c489.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/81e107e78c0f4c01abbe63f378d1c489"}}, "title": "Early experience of COVID-19 vaccination in adults with systemic rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey.", "authors": [{"family": "Sattui", "given": "Sebastian Eduardo", "initials": "SE", "orcid": "0000-0002-3945-6828", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58eb263e05ae4014897c534b20631833.json"}}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Kennedy", "given": "Kevin", "initials": "K", "orcid": "0000-0001-8230-091X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2e92ad85b0e843e3b11d71e87aa1edaf.json"}}, {"family": "Sirotich", "given": "Emily", "initials": "E", "orcid": "0000-0002-7087-8543", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c5dfbc359844544aa3684d916185fac.json"}}, {"family": "Putman", "given": "Michael", "initials": "M"}, {"family": "Moni", "given": "Tarin T", "initials": "TT"}, {"family": "Akpabio", "given": "Akpabio", "initials": "A", "orcid": "0000-0002-4920-6494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a237df6d34e4f7da430d8d71bc73d45.json"}}, {"family": "Alp\u00edzar-Rodr\u00edguez", "given": "Deshir\u00e9", "initials": "D", "orcid": "0000-0002-6930-0517", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44724489165b403d8cb39923240c7136.json"}}, {"family": "Berenbaum", "given": "Francis", "initials": "F", "orcid": "0000-0001-8252-7815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c14dfcd19e6a40e78373f28030d22b12.json"}}, {"family": "Bulina", "given": "Inita", "initials": "I"}, {"family": "Conway", "given": "Richard", "initials": "R", "orcid": "0000-0003-2538-3362", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77fe264e6d0d4c87b734f3fa02e42c15.json"}}, {"family": "Singh", "given": "Aman Dev", "initials": "AD"}, {"family": "Duff", "given": "Eimear", "initials": "E"}, {"family": "Durrant", "given": "Karen L", "initials": "KL"}, {"family": "Gheita", "given": "Tamer A", "initials": "TA"}, {"family": "Hill", "given": "Catherine L", "initials": "CL"}, {"family": "Howard", "given": "Richard A", "initials": "RA"}, {"family": "Hoyer", "given": "Bimba F", "initials": "BF"}, {"family": "Hsieh", "given": "Evelyn", "initials": "E"}, {"family": "El Kibbi", "given": "Lina", "initials": "L"}, {"family": "Kilian", "given": "Adam", "initials": "A"}, {"family": "Kim", "given": "Alfred Hyoungju", "initials": "AH", "orcid": "0000-0003-4074-0516", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5e89146ab5d45f8b436df9ff7e279e8.json"}}, {"family": "Liew", "given": "David F L", "initials": "DFL"}, {"family": "Lo", "given": "Chieh", "initials": "C"}, {"family": "Miller", "given": "Bruce", "initials": "B"}, {"family": "Mingolla", "given": "Serena", "initials": "S"}, {"family": "Nudel", "given": "Michal", "initials": "M"}, {"family": "Palmerlee", "given": "Candace A", "initials": "CA"}, {"family": "Singh", "given": "Jasvinder A", "initials": "JA", "orcid": "0000-0003-3485-0006", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e70577b3133946d097e7e21e739b8aec.json"}}, {"family": "Singh", "given": "Namrata", "initials": "N"}, {"family": "Ugarte-Gil", "given": "Manuel Francisco", "initials": "MF", "orcid": "0000-0003-1728-1999", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b49a52ac208747ed9b85f286119da620.json"}}, {"family": "Wallace", "given": "John", "initials": "J"}, {"family": "Young", "given": "Kristen J", "initials": "KJ"}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Costello", "given": "Wendy", "initials": "W"}, {"family": "Grainger", "given": "Rebecca", "initials": "R"}, {"family": "Machado", "given": "Pedro M", "initials": "PM", "orcid": "0000-0002-8411-7972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef40d1eea57946e4a37d2e92a02a47cd.json"}}, {"family": "Robinson", "given": "Philip C", "initials": "PC", "orcid": "0000-0002-3156-3418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/950b622d31724172817ccde09902d215.json"}}, {"family": "Sufka", "given": "Paul", "initials": "P"}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Yazdany", "given": "Jinoos", "initials": "J"}, {"family": "Harrison", "given": "Carly", "initials": "C"}, {"family": "Larch\u00e9", "given": "Maggie", "initials": "M"}, {"family": "Levine", "given": "Mitchell", "initials": "M"}, {"family": "Foster", "given": "Gary", "initials": "G"}, {"family": "Thabane", "given": "Lehana", "initials": "L"}, {"family": "Rider", "given": "Lisa G", "initials": "LG"}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS", "orcid": "0000-0003-0786-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d99dc166f48d4af7b8e46dc999c7444b.json"}}, {"family": "Simard", "given": "Julia F", "initials": "JF", "orcid": "0000-0001-5735-9856", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ac28a1c6150426997d458b40c43f512.json"}}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA", "orcid": "0000-0002-5556-4618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/192552e5e3d2435799e57111ea84502d.json"}}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "RMD Open", "issn": "2056-5933", "volume": "7", "issue": "3", "issn-l": null}, "abstract": "We describe the early experiences of adults with systemic rheumatic disease who received the COVID-19 vaccine.\n\nFrom 2 April to 30 April 2021, we conducted an online, international survey of adults with systemic rheumatic disease who received COVID-19 vaccination. We collected patient-reported data on clinician communication, beliefs and intent about discontinuing disease-modifying antirheumatic drugs (DMARDs) around the time of vaccination, and patient-reported adverse events after vaccination.\n\nWe analysed 2860 adults with systemic rheumatic diseases who received COVID-19 vaccination (mean age 55.3 years, 86.7% female, 86.3% white). Types of COVID-19 vaccines were Pfizer-BioNTech (53.2%), Oxford/AstraZeneca (22.6%), Moderna (21.3%), Janssen/Johnson & Johnson (1.7%) and others (1.2%). The most common rheumatic disease was rheumatoid arthritis (42.3%), and 81.2% of respondents were on a DMARD. The majority (81.9%) reported communicating with clinicians about vaccination. Most (66.9%) were willing to temporarily discontinue DMARDs to improve vaccine efficacy, although many (44.3%) were concerned about rheumatic disease flares. After vaccination, the most reported patient-reported adverse events were fatigue/somnolence (33.4%), headache (27.7%), muscle/joint pains (22.8%) and fever/chills (19.9%). Rheumatic disease flares that required medication changes occurred in 4.6%.\n\nAmong adults with systemic rheumatic disease who received COVID-19 vaccination, patient-reported adverse events were typical of those reported in the general population. Most patients were willing to temporarily discontinue DMARDs to improve vaccine efficacy. The relatively low frequency of rheumatic disease flare requiring medications was reassuring.", "doi": "10.1136/rmdopen-2021-001814", "pmid": "34493645", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "rmdopen-2021-001814"}], "notes": [], "created": "2021-09-09T05:41:15.198Z", "modified": "2021-09-09T05:42:15.542Z"}, {"entity": "publication", "iuid": "df2cb94bee5e4e78bdb2368bb1ad1e87", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/df2cb94bee5e4e78bdb2368bb1ad1e87.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/df2cb94bee5e4e78bdb2368bb1ad1e87"}}, "title": "Dismantling internet-based cognitive behavioral therapy for tinnitus. The contribution of applied relaxation: A randomized controlled trial.", "authors": [{"family": "Beukes", "given": "Eldr\u00e9 W", "initials": "EW"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Fagelson", "given": "Marc A", "initials": "MA"}, {"family": "Manchaiah", "given": "Vinaya", "initials": "V"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Internet Interv", "issn": "2214-7829", "volume": "25", "issue": null, "pages": "100402", "issn-l": "2214-7829"}, "abstract": "Internet-based cognitive behavioral therapy (ICBT) for tinnitus is an evidence-based intervention. The components of ICBT for tinnitus have, however, not been dismantled and thus the effectiveness of the different therapeutic components is unknown. It is, furthermore, not known if heterogeneous tinnitus subgroups respond differently to ICBT.\n\nThis dismantling study aimed to explore the contribution of applied relaxation within ICBT for reducing tinnitus distress and comorbidities associated with tinnitus. A secondary aim was to assess whether outcomes varied for three tinnitus subgroups, namely those with significant tinnitus severity, those with low tinnitus severity, and those with significant depression.\n\nA parallel randomized controlled trial design ( n = 126) was used to compare audiologist-guided applied relaxation with the full ICBT intervention. Recruitment was online and via the intervention platform. Assessments were completed at four-time points including a 2-month follow-up period. The primary outcome was tinnitus severity as measured by the Tinnitus Functional Index. Secondary outcomes were included for anxiety, depression, insomnia, negative tinnitus cognitions, health-related quality of life, hearing disability, and hyperacusis. Treatment engagement variables including the number of logins, number of modules opened, and the number of messages sent. Both an intention-to-treat analysis and completer's only analysis were undertaken.\n\nEngagement was low which compromised results as the full intervention was undertaken by few participants. Both the ICBT and applied relaxation resulted in large reduction of tinnitus severity (within-group effect sizes d = 0.87 and 0.68, respectively for completers only analysis), which were maintained, or further improved at follow-up. These reductions in tinnitus distress were greater for the ICBT group, with a small effect size differences (between-group d = 0.15 in favor of ICBT for completers only analysis). Tinnitus distress decreased the most at post-intervention for those with significant depression at baseline. Both ICBT and applied relaxation contributed to significant reductions on most secondary outcome measures, with no group differences, except for a greater reduction of hyperacusis in the ICBT group.\n\nDue to poor compliance partly attributed to the COVID-19 pandemic results were compromised. Further studies employing strategies to improve compliance and engagement are required. The intervention's effectiveness increased with initial level of tinnitus distress; those with the highest scores at intake experienced the most substantial changes on the outcome measures. This may suggest tailoring of interventions according to tinnitus severity. Larger samples are needed to confirm this.", "doi": "10.1016/j.invent.2021.100402", "pmid": "34040997", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2214-7829(21)00042-7"}, {"db": "pmc", "key": "PMC8141772"}, {"db": "URL", "key": "https://doi.org/10.6084/m9.figshare.13679179", "description": "Dataset, demographic questionnaire and metadata"}], "notes": [], "created": "2021-05-29T15:31:18.566Z", "modified": "2021-11-19T10:52:32.033Z"}, {"entity": "publication", "iuid": "7952fb75226c454491af5321fd3fa6a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7952fb75226c454491af5321fd3fa6a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7952fb75226c454491af5321fd3fa6a6"}}, "title": "Development of humoral and cellular immunological memory against SARS-CoV-2 despite B cell depleting treatment in multiple sclerosis", "authors": [{"family": "Asplund H\u00f6gelin", "given": "Klara", "initials": "K"}, {"family": "Ruffin", "given": "Nicolas", "initials": "N", "orcid": "0000-0002-3698-5505", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15efeb249ce44bb0ab2bc6017d2548d0.json"}}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Gafvelin", "given": "Guro", "initials": "G"}, {"family": "Gr\u00f6nlund", "given": "Hans", "initials": "H"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Khademi", "given": "Mohsen", "initials": "M"}, {"family": "Olsson", "given": "Tomas", "initials": "T"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Al Nimer", "given": "Faiez", "initials": "F"}], "type": "journal-article", "published": "2021-09-00", "journal": {"title": "iScience", "issn": "2589-0042", "issn-l": "2589-0042", "volume": "24", "issue": "9", "pages": "103078"}, "abstract": "B cell depleting therapies (BCDTs) are widely used as immunomodulating agents for autoimmune diseases such as multiple sclerosis. Their possible impact on development of immunity to severe acute respiratory syndrome virus-2 (SARS-CoV-2) has raised concerns with the coronavirus disease 2019 (COVID-19) pandemic. We here evaluated the frequency of COVID-19-like symptoms and determined immunological responses in participants of an observational trial comprising several multiple sclerosis disease modulatory drugs (COMBAT-MS; NCT03193866) and in eleven patients after vaccination, with a focus on BCDT. Almost all seropositive and 17.9% of seronegative patients on BCDT, enriched for a history of COVID-19-like symptoms, developed anti-SARS-CoV-2 T cell memory, and T cells displayed functional similarity to controls producing IFN-\u03b3 and TNF. Following vaccination, vaccine-specific humoral memory was impaired, while all patients developed a specific T cell response. These results indicate that BCDTs do not abrogate SARS-CoV-2 cellular memory and provide a possible explanation as to why the majority of patients on BCDTs recover from COVID-19.", "doi": "10.1016/j.isci.2021.103078", "pmid": "34490414", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Vaccine": null, "Research Area: High-throughput and high-content serology": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(21)01046-4"}, {"db": "pmc", "key": "PMC8410640"}], "notes": [], "created": "2021-09-09T05:36:02.573Z", "modified": "2021-12-13T08:58:20.658Z"}, {"entity": "publication", "iuid": "cedc0f4e7276462dbce1cf4d8fdf6cf0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cedc0f4e7276462dbce1cf4d8fdf6cf0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cedc0f4e7276462dbce1cf4d8fdf6cf0"}}, "title": "Conducting a multi-country online alcohol survey in the time of the COVID-19 pandemic: Opportunities and challenges.", "authors": [{"family": "Kilian", "given": "Carolin", "initials": "C", "orcid": "0000-0001-5913-6488", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed0409bb90b346cd9001bebb46bdcf87.json"}}, {"family": "Rehm", "given": "J\u00fcrgen", "initials": "J", "orcid": "0000-0001-5665-0385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83f5b8ddf5844eb6a1118d8ec4c4dca2.json"}}, {"family": "Allebeck", "given": "Peter", "initials": "P", "orcid": "0000-0002-2778-6467", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de9f0e1c3e4d402b93e61ad1c5a771fb.json"}}, {"family": "Bart\u00e1k", "given": "Miroslav", "initials": "M", "orcid": "0000-0002-7265-6514", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77e98268e4ef42f6a5a036b75d6a1c56.json"}}, {"family": "Braddick", "given": "Fleur", "initials": "F", "orcid": "0000-0001-6755-4567", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e9df2867269470ab43dd6802b5abb49.json"}}, {"family": "Gual", "given": "Antoni", "initials": "A", "orcid": "0000-0002-7130-981X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a9b53e2b8644056920e73b5b1d014d9.json"}}, {"family": "Matrai", "given": "Silvia", "initials": "S", "orcid": "0000-0002-0308-7354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/333166e20d4e4bf99ce09910268ab080.json"}}, {"family": "Petru\u017eelka", "given": "Benjamin", "initials": "B", "orcid": "0000-0003-0318-3589", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/135b991aff2a486cb76a4f362d85b5e6.json"}}, {"family": "Rogalewicz", "given": "Vladimir", "initials": "V", "orcid": "0000-0001-5432-4148", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/904dc3953e4e42d4ac5f317f7b3c5b36.json"}}, {"family": "Rossow", "given": "Ingeborg", "initials": "I", "orcid": "0000-0001-8652-9367", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab426c14c36143d0bd2da8eb86f74e97.json"}}, {"family": "Schulte", "given": "Bernd", "initials": "B", "orcid": "0000-0003-1139-030X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79c126298bdf42518d5d0384a7e1ec42.json"}}, {"family": "\u0160telem\u0117kas", "given": "Mindaugas", "initials": "M", "orcid": "0000-0002-2040-6900", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56ebd7e17fe04fd788add93ee5c3324d.json"}}, {"family": "Manthey", "given": "Jakob", "initials": "J", "orcid": "0000-0003-1231-3760", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5e779db5bf14c38aad0f3a964b7d9bd.json"}}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Int J Methods Psychiatr Res", "issn": "1557-0657", "issn-l": null, "volume": "30", "issue": "3", "pages": "e1875"}, "abstract": "This contribution provides insights into the methodology of a pan-European population-based online survey, performed without external funding during the COVID-19 pandemic. We present the impact of different dissemination strategies to collect data from a non-probabilistic convenience sample and outline post-stratification weighting schemes, to provide guidance for future multi-country survey studies.\n\nDescription and comparison of dissemination strategies for five exemplary countries (Czechia, Germany, Lithuania, Norway, Spain) participating in the Alcohol Use and COVID-19 Survey. Comparison of the sample distribution with the country's actual population distribution according to sociodemographics, and development of weighting schemes.\n\nThe dissemination of online surveys through national newspapers, paid social media adverts and dissemination with the support of national health ministries turned out to be the most effective strategies. Monitoring the responses and adapting dissemination strategies to reach under-represented groups, and the application of sample weights were helpful to achieve an analytic sample matching the respective general population profiles.\n\nReaching a large pan-European convenience sample, including most European countries, in a short time was feasible, with the support of a broad scientific network.", "doi": "10.1002/mpr.1875", "pmid": "33951258", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8209885"}, {"db": "figshare", "key": "10.6084/m9.figshare.13580693.v1"}], "notes": [], "created": "2021-05-06T05:52:12.283Z", "modified": "2023-06-19T07:33:03.794Z"}, {"entity": "publication", "iuid": "23272de6f88949138a758530f7ceb860", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23272de6f88949138a758530f7ceb860.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23272de6f88949138a758530f7ceb860"}}, "title": "Comparable endemic coronavirus nucleoprotein-specific antibodies in mild and severe Covid-19 patients.", "authors": [{"family": "Leach", "given": "Susannah", "initials": "S", "orcid": "0000-0002-9614-2753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18d00be831d241dca238b3253d1b45f6.json"}}, {"family": "Harandi", "given": "Ali M", "initials": "AM"}, {"family": "Bergstr\u00f6m", "given": "Tomas", "initials": "T"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "van der Hoek", "given": "Lia", "initials": "L"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "J Med Virol", "issn": "1096-9071", "issn-l": null, "volume": "93", "issue": "9", "pages": "5614-5617"}, "abstract": "The severity of disease of Covid-19 is highly variable, ranging from asymptomatic to critical respiratory disease and death. Potential cross-reactive immune responses between SARS-CoV-2 and endemic coronavirus (eCoV) may hypothetically contribute to this variability. We herein studied if eCoV nucleoprotein (N)-specific antibodies in the sera of patients with mild or severe Covid-19 are associated with Covid-19 severity. There were comparable levels of eCoV N-specific antibodies early and during the first month of infection in Covid-19 patients with mild and severe symptoms, and healthy SARS-CoV-2-negative subjects. These results warrant further studies to investigate the potential role of eCoV-specific antibodies in immunity to SARS-CoV-2 infection.", "doi": "10.1002/jmv.27038", "pmid": "33913546", "labels": {"Funder: Vinnova": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC8242474"}], "notes": [], "created": "2021-04-30T04:12:21.490Z", "modified": "2021-12-12T18:08:26.325Z"}, {"entity": "publication", "iuid": "d683d834f14e47f488d2376e7e0114ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d683d834f14e47f488d2376e7e0114ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d683d834f14e47f488d2376e7e0114ca"}}, "title": "COVID-19 and Its Triangle Effects on Human's Well-Being: a Qualitative Research Method Used to Collect Appropriate Data.", "authors": [{"family": "Fatahi", "given": "Nabi", "initials": "N"}, {"family": "Kakamad", "given": "Karwan", "initials": "K"}, {"family": "Babakr", "given": "Zana", "initials": "Z"}, {"family": "Tafran", "given": "Khaled", "initials": "K"}, {"family": "\u00d8kland", "given": "\u00d8yvind", "initials": "\u00d8"}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Acta Inform Med", "issn": "0353-8109", "issn-l": null, "volume": "29", "issue": "3", "pages": "197-204"}, "abstract": "The health-related challenges caused by the virus and the implications of the policies implemented to fight against it further cause psychological and socio-economic consequences that could threaten the well-being of the people.\r\n\r\nThis study has been carried out to identify people's psychosoical reactions toward COVID-19.\r\n\r\nSemi-structured interviews as a qualitative research method were used to collect data from 20 people across three countries, and content analysis was applied to interpret the data.\r\n\r\nOverall, the results indicated that COVID-19 has had negative consequences on psychological well-being of the general population. COVID-19 has forced people to maintain social distance and has led to family conflicts in some families. Moreover, COVID-19 has caused loss of jobs and mental health problems.\r\n\r\nCOVID-19 has affected people's daily life and a significant influence on individuals and society. This research demonstrates some of the ramifications in terms of psychological well-being of the general population. One of the most important findings is the importance of social life and meeting people in person, not just online. The current pandemic is influencing people's psychological well-being in a variety of ways.", "doi": "10.5455/aim.2021.29.197-204", "pmid": "34759460", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "AIM-29-197"}, {"db": "pmc", "key": "PMC8563050"}], "notes": [], "created": "2021-11-26T15:17:35.417Z", "modified": "2022-11-23T08:52:38.642Z"}, {"entity": "publication", "iuid": "cd4149ce45ee4f1f899ff2e3efacc239", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd4149ce45ee4f1f899ff2e3efacc239.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd4149ce45ee4f1f899ff2e3efacc239"}}, "title": "Antiphospholipid antibodies and neurological manifestations in acute COVID-19: A single-centre cross-sectional study.", "authors": [{"family": "Benjamin", "given": "Laura A", "initials": "LA", "orcid": "0000-0002-9685-1664", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15ffcba9a1b94d2d9d33c533c03a23d5.json"}}, {"family": "Paterson", "given": "Ross W", "initials": "RW"}, {"family": "Moll", "given": "Rachel", "initials": "R"}, {"family": "Pericleous", "given": "Charis", "initials": "C"}, {"family": "Brown", "given": "Rachel", "initials": "R"}, {"family": "Mehta", "given": "Puja R", "initials": "PR"}, {"family": "Athauda", "given": "Dilan", "initials": "D"}, {"family": "Ziff", "given": "Oliver J", "initials": "OJ"}, {"family": "Heaney", "given": "Judith", "initials": "J"}, {"family": "Checkley", "given": "Anna M", "initials": "AM"}, {"family": "Houlihan", "given": "Catherine F", "initials": "CF"}, {"family": "Chou", "given": "Michael", "initials": "M"}, {"family": "Heslegrave", "given": "Amanda J", "initials": "AJ"}, {"family": "Chandratheva", "given": "Arvind", "initials": "A"}, {"family": "Michael", "given": "Benedict D", "initials": "BD"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Vivekanandam", "given": "Vinojini", "initials": "V"}, {"family": "Foulkes", "given": "Alexander", "initials": "A"}, {"family": "Mummery", "given": "Catherine J", "initials": "CJ"}, {"family": "Lunn", "given": "Michael P", "initials": "MP"}, {"family": "Keddie", "given": "Stephen", "initials": "S"}, {"family": "Spyer", "given": "Moira J", "initials": "MJ"}, {"family": "Mckinnon", "given": "Tom", "initials": "T"}, {"family": "Hart", "given": "Melanie", "initials": "M", "orcid": "0000-0002-7396-1916", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c6e01af5c6d4e5e8fed4f1404d1ad5c.json"}}, {"family": "Carletti", "given": "Francesco", "initials": "F"}, {"family": "J\u00e4ger", "given": "Hans Rolf", "initials": "HR"}, {"family": "Manji", "given": "Hadi", "initials": "H"}, {"family": "Zandi", "given": "Michael S", "initials": "MS"}, {"family": "Werring", "given": "David J", "initials": "DJ"}, {"family": "Nastouli", "given": "Eleni", "initials": "E"}, {"family": "Simister", "given": "Robert", "initials": "R"}, {"family": "Solomon", "given": "Tom", "initials": "T"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Schott", "given": "Jonathan M", "initials": "JM"}, {"family": "Cohen", "given": "Hannah", "initials": "H"}, {"family": "Efthymiou", "given": "Maria", "initials": "M"}, {"family": "UCLH Queen Square COVID-19 Biomarker Study group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "issn-l": null, "volume": "39", "issue": null, "pages": "101070"}, "abstract": "A high prevalence of antiphospholipid antibodies has been reported in case series of patients with neurological manifestations and COVID-19; however, the pathogenicity of antiphospholipid antibodies in COVID-19 neurology remains unclear.\n\nThis single-centre cross-sectional study included 106 adult patients: 30 hospitalised COVID-neurological cases, 47 non-neurological COVID-hospitalised controls, and 29 COVID-non-hospitalised controls, recruited between March and July 2020. We evaluated nine antiphospholipid antibodies: anticardiolipin antibodies [aCL] IgA, IgM, IgG; anti-beta-2 glycoprotein-1 [a\u03b22GPI] IgA, IgM, IgG; anti-phosphatidylserine/prothrombin [aPS/PT] IgM, IgG; and anti-domain I \u03b22GPI (aD1\u03b22GPI) IgG.\n\nThere was a high prevalence of antiphospholipid antibodies in the COVID-neurological (73.3%) and non-neurological COVID-hospitalised controls (76.6%) in contrast to the COVID-non-hospitalised controls (48.2%). aPS/PT IgG titres were significantly higher in the COVID-neurological group compared to both control groups (p < 0.001). Moderate-high titre of aPS/PT IgG was found in 2 out of 3 (67%) patients with acute disseminated encephalomyelitis [ADEM]. aPS/PT IgG titres negatively correlated with oxygen requirement (FiO2 R=-0.15 p = 0.040) and was associated with venous thromboembolism (p = 0.043). In contrast, aCL IgA (p < 0.001) and IgG (p < 0.001) was associated with non-neurological COVID-hospitalised controls compared to the other groups and correlated positively with d-dimer and creatinine but negatively with FiO2.\n\nOur findings show that aPS/PT IgG is associated with COVID-19-associated ADEM. In contrast, aCL IgA and IgG are seen much more frequently in non-neurological hospitalised patients with COVID-19. Characterisation of antiphospholipid antibody persistence and potential longitudinal clinical impact are required to guide appropriate management.\n\nThis work is supported by UCL Queen Square Biomedical Research Centre (BRC) and Moorfields BRC grants (#560441 and #557595). LB is supported by a Wellcome Trust Fellowship (222102/Z/20/Z). RWP is supported by an Alzheimer's Association Clinician Scientist Fellowship (AACSF-20-685780) and the UK Dementia Research Institute. KB is supported by the Swedish Research Council (#2017-00915) and the Swedish state under the agreement between the Swedish government and the County Councils, the ALF-agreement (#ALFGBG-715986). HZ is a Wallenberg Scholar supported by grants from the Swedish Research Council (#2018-02532), the European Research Council (#681712), Swedish State Support for Clinical Research (#ALFGBG-720931), the Alzheimer Drug Discovery Foundation (ADDF), USA (#201809-2016862), and theUK Dementia Research Institute at UCL. BDM is supported by grants from the MRC/UKRI (MR/V007181/1), MRC (MR/T028750/1) and Wellcome (ISSF201902/3). MSZ, MH and RS are supported by the UCL/UCLH NIHR Biomedical Research Centre and MSZ is supported by Queen Square National Brain Appeal.", "doi": "10.1016/j.eclinm.2021.101070", "pmid": "34401683", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC8358233"}, {"db": "pii", "key": "S2589-5370(21)00350-3"}], "notes": [], "created": "2021-08-18T07:31:21.399Z", "modified": "2023-06-19T14:53:11.303Z"}, {"entity": "publication", "iuid": "dea56f4dcd0c4470b38876ee38e5d449", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dea56f4dcd0c4470b38876ee38e5d449.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dea56f4dcd0c4470b38876ee38e5d449"}}, "title": "Prognostic Significance of Chest Imaging by LUS and CT in COVID-19 Inpatients: The ECOVID Multicenter Study.", "authors": [{"family": "Tana", "given": "Claudio", "initials": "C"}, {"family": "Ricci", "given": "Fabrizio", "initials": "F"}, {"family": "Coppola", "given": "Maria Gabriella", "initials": "MG"}, {"family": "Mantini", "given": "Cesare", "initials": "C"}, {"family": "Lauretani", "given": "Fulvio", "initials": "F"}, {"family": "Campanozzi", "given": "Daniele", "initials": "D"}, {"family": "Renda", "given": "Giulia", "initials": "G"}, {"family": "Gallina", "given": "Sabina", "initials": "S"}, {"family": "Lugar\u00e1", "given": "Marina", "initials": "M"}, {"family": "Cipollone", "given": "Francesco", "initials": "F"}, {"family": "Giamberardino", "given": "Maria Adele", "initials": "MA"}, {"family": "Mucci", "given": "Luciano", "initials": "L"}], "type": "journal article", "published": "2021-08-31", "journal": {"title": "Respiration", "issn": "1423-0356", "pages": "1-10", "issn-l": null}, "abstract": "Point-of-care lung ultrasound (LUS) score is a semiquantitative score of lung damage severity. High-resolution computed tomography (HRCT) is the gold standard method to evaluate the severity of lung involvement from the novel coronavirus disease (COVID-19). Few studies have investigated the clinical significance of LUS and HRCT scores in patients with COVID-19. Therefore, the aim of this study was to evaluate the prognostic yield of LUS and of HRCT in COVID-19 patients.\n\nWe carried out a multicenter, retrospective study aimed at evaluating the prognostic yield of LUS and HRCT by exploring the survival curve of COVID-19 inpatients. LUS and chest CT scores were calculated retrospectively by 2 radiologists with >10 years of experience in chest imaging, and the decisions were reached in consensus. LUS score was calculated on the basis of the presence or not of pleural line abnormalities, B-lines, and lung consolidations. The total score (range 0-36) was obtained from the sum of the highest scores obtained in each region. CT score was calculated for each of the 5 lobes considering the anatomical extension according to the percentage parenchymal involvement. The resulting overall global semiquantitative CT score was the sum of each single lobar score and ranged from 0 (no involvement) to 25 (maximum involvement).\n\nOne hundred fifty-three COVID-19 inpatients (mean age 65 \u00b1 15 years; 65% M), including 23 (15%) in-hospital deaths for any cause over a mean follow-up of 14 days were included. Mean LUS and CT scores were 19 \u00b1 12 and 10 \u00b1 7, respectively. A strong positive linear correlation between LUS and CT scores (Pearson correlation r = 0.754; R2 = 0.568; p < 0.001) was observed. By ROC curve analysis, the optimal cut-point for mortality prediction was 20 for LUS score and 4.5 for chest CT score. According to Kaplan-Meier survival analysis, in-hospital mortality significantly increased among COVID-19 patients presenting with an LUS score \u226520 (log-rank 0.003; HR 9.87, 95% CI: 2.22-43.83) or a chest CT score \u22654.5 (HR 4.34, 95% CI: 0.97-19.41). At multivariate Cox regression analysis, LUS score was the sole independent predictor of in-hospital mortality yielding an adjusted HR of 7.42 (95% CI: 1.59-34.5).\n\nLUS score is useful to stratify the risk in COVID-19 patients, predicting those that are at high risk of mortality.", "doi": "10.1159/000518516", "pmid": "34515247", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "000518516"}], "notes": [], "created": "2021-09-20T06:32:43.318Z", "modified": "2021-09-20T06:32:43.341Z"}, {"entity": "publication", "iuid": "7ca4e632c1764964a21e57705c6ff32a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7ca4e632c1764964a21e57705c6ff32a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7ca4e632c1764964a21e57705c6ff32a"}}, "title": "Negative effects of iodine-based contrast agent on renal function in patients with moderate reduced renal function hospitalized for COVID-19.", "authors": [{"family": "Kistner", "given": "Anna", "initials": "A", "orcid": "0000-0002-7942-3211", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/833e8a08aed54e66bf271a795f93507f.json"}}, {"family": "Tamm", "given": "Chen", "initials": "C"}, {"family": "Svensson", "given": "Ann Mari", "initials": "AM"}, {"family": "Beckman", "given": "Mats O", "initials": "MO"}, {"family": "Strand", "given": "Fredrik", "initials": "F"}, {"family": "Sk\u00f6ld", "given": "Magnus", "initials": "M"}, {"family": "Nyr\u00e9n", "given": "Sven", "initials": "S"}], "type": "journal article", "published": "2021-08-31", "journal": {"title": "BMC Nephrol", "issn": "1471-2369", "volume": "22", "issue": "1", "pages": "297", "issn-l": null}, "abstract": "Kidney disease and renal failure are associated with hospital deaths in patients with COVID - 19. We aimed to test if contrast enhancement affects short-term renal function in hospitalized COVID - 19 patients.\n\nPlasma creatinine (P-creatinine) was measured on the day of computed tomography (CT) and 24 h, 48 h, and 4-10 days after CT. Contrast-enhanced (n = 142) and unenhanced (n = 24) groups were subdivided, based on estimated glomerular filtration rates (eGFR), > 60 and \u2264 60 ml/min/1.73 m2. Contrast-induced acute renal failure (CI-AKI) was defined as \u226527 \u03bcmol/L increase or a > 50% rise in P-creatinine from CT or initiation of renal replacement therapy during follow-up. Patients with renal replacement therapy were studied separately. We evaluated factors associated with a > 50% rise in P-creatinine at 48 h and at 4-10 days after contrast-enhanced CT.\n\nMedian P-creatinine at 24-48 h and days 4-10 post-CT in patients with eGFR> 60 and eGFR\u226530-60 in contrast-enhanced and unenhanced groups did not differ from basal values. CI-AKI was observed at 48 h and at 4-10 days post contrast administration in 24 and 36% (n = 5/14) of patients with eGFR\u226530-60. Corresponding figures in the eGFR> 60 contrast-enhanced CT group were 5 and 5% respectively, (p < 0.037 and p < 0.001, Pearson \u03c72 test). In the former group, four of the five patients died within 30 days. Odds ratio analysis showed that an eGFR\u226530-60 and 30-day mortality were associated with CK-AKI both at 48 h and 4-10 days after contrast-enhanced CT.\n\nPatients with COVID - 19 and eGFR\u226530-60 had a high frequency of CK-AKI at 48 h and at 4-10 days after contrast administration, which was associated with increased 30-day mortality. For patients with eGFR\u226530-60, we recommend strict indications are practiced for contrast-enhanced CT. Contrast-enhanced CT had a modest effect in patients with eGFR> 60.", "doi": "10.1186/s12882-021-02469-w", "pmid": "34465289", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12882-021-02469-w"}, {"db": "pmc", "key": "PMC8407403"}], "notes": [], "created": "2021-09-06T06:21:51.895Z", "modified": "2021-09-06T06:21:51.945Z"}, {"entity": "publication", "iuid": "1a003c7f725c4e19aeee8cb678f456ed", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1a003c7f725c4e19aeee8cb678f456ed.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1a003c7f725c4e19aeee8cb678f456ed"}}, "title": "Intermarriage and COVID-19 mortality among immigrants. A population-based cohort study from Sweden.", "authors": [{"family": "Aradhya", "given": "Siddartha", "initials": "S", "orcid": "0000-0003-3748-6270", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07f9e1a0528249a7ba6d39e2c0f3a7fe.json"}}, {"family": "Brand\u00e9n", "given": "Maria", "initials": "M"}, {"family": "Drefahl", "given": "Sven", "initials": "S"}, {"family": "Obu\u0107ina", "given": "Ognjen", "initials": "O"}, {"family": "Andersson", "given": "Gunnar", "initials": "G"}, {"family": "Rostila", "given": "Mikael", "initials": "M"}, {"family": "Mussino", "given": "Eleonora", "initials": "E"}, {"family": "Ju\u00e1rez", "given": "Sol P\u00eda", "initials": "SP", "orcid": "0000-0001-9086-7588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7cb8065d45a4969857ebbc65d01a619.json"}}], "type": "journal article", "published": "2021-08-31", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "9", "pages": "e048952"}, "abstract": "To evaluate the role of language proficiency and institutional awareness in explaining excess COVID-19 mortality among immigrants.\n\nCohort study with follow-up between 12 March 2020 and 23 February 2021.\n\nSwedish register-based study on all residents in Sweden.\n\n3 963 356 Swedish residents in co-residential unions who were 30 years of age or older and alive on 12 March 2020 and living in Sweden in December 2019.\n\nCox regression models were conducted to assess the association between different constellations of immigrant-native couples (proxy for language proficiency and institutional awareness) and COVID-19 mortality and all other causes of deaths (2019 and 2020). Models were adjusted for relevant confounders.\n\nCompared with Swedish-Swedish couples (1.18 deaths per thousand person-years), both immigrants partnered with another immigrant and a native showed excess mortality for COVID-19 (HR 1.43; 95% CI 1.29 to 1.58 and HR 1.24; 95% CI 1.10 to 1.40, respectively), which translates to 1.37 and 1.28 deaths per thousand person-years. Moreover, similar results are found for natives partnered with an immigrant (HR 1.15; 95% CI 1.02 to 1.29), which translates to 1.29 deaths per thousand person-years. Further analysis shows that immigrants from both high-income and low-income and middle-income countries (LMIC) experience excess mortality also when partnered with a Swede. However, having a Swedish-born partner is only partially protective against COVID-19 mortality among immigrants from LMIC origins.\n\nLanguage barriers and/or poor institutional awareness are not major drivers for the excess mortality from COVID-19 among immigrants. Rather, our study provides suggestive evidence that excess mortality among immigrants is explained by differential exposure to the virus.", "doi": "10.1136/bmjopen-2021-048952", "pmid": "34465581", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8413476"}, {"db": "pii", "key": "bmjopen-2021-048952"}], "notes": [], "created": "2021-09-06T06:21:38.437Z", "modified": "2023-01-13T14:42:16.876Z"}, {"entity": "publication", "iuid": "edaa9c0fdc684b87a74e9042bf94b470", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/edaa9c0fdc684b87a74e9042bf94b470.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/edaa9c0fdc684b87a74e9042bf94b470"}}, "title": "Editorial: The Different Faces of Sickness.", "authors": [{"family": "Rademacher", "given": "Lena", "initials": "L"}, {"family": "Lasselin", "given": "Julie", "initials": "J"}, {"family": "Karshikoff", "given": "Bianka", "initials": "B"}, {"family": "Hundt", "given": "Jennifer E", "initials": "JE"}, {"family": "Engler", "given": "Harald", "initials": "H"}, {"family": "Lange", "given": "Tanja", "initials": "T"}], "type": "editorial", "published": "2021-08-31", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "pages": "735337", "issn-l": "1664-0640"}, "abstract": null, "doi": "10.3389/fpsyt.2021.735337", "pmid": "34531771", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8438174"}], "notes": [], "created": "2021-09-20T16:55:00.580Z", "modified": "2021-09-20T16:55:00.590Z"}, {"entity": "publication", "iuid": "02137f9a606f465db43e1cd4d73138d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02137f9a606f465db43e1cd4d73138d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02137f9a606f465db43e1cd4d73138d0"}}, "title": "Online teaching in physiotherapy education during COVID-19 pandemic in Italy: a retrospective case-control study on students' satisfaction and performance.", "authors": [{"family": "Rossettini", "given": "Giacomo", "initials": "G"}, {"family": "Geri", "given": "Tommaso", "initials": "T"}, {"family": "Turolla", "given": "Andrea", "initials": "A"}, {"family": "Viceconti", "given": "Antonello", "initials": "A"}, {"family": "Scum\u00e0", "given": "Cristina", "initials": "C"}, {"family": "Mirandola", "given": "Mattia", "initials": "M"}, {"family": "Dell'Isola", "given": "Andrea", "initials": "A"}, {"family": "Gianola", "given": "Silvia", "initials": "S"}, {"family": "Maselli", "given": "Filippo", "initials": "F"}, {"family": "Palese", "given": "Alvisa", "initials": "A"}], "type": "journal article", "published": "2021-08-30", "journal": {"title": "BMC Med Educ", "issn": "1472-6920", "volume": "21", "issue": "1", "pages": "456", "issn-l": null}, "abstract": "During COVID-19 pandemic, physiotherapy lecturers faced the challenge of rapidly shifting from face-to-face to online education. This retrospective case-control study aims to compare students' satisfaction and performances shown in an online course to a control group of students who underwent the same course delivered face-to-face in the previous five years.\n\nBetween March and April 2020, a class (n = 46) of entry-level physiotherapy students (University of Verona - Italy), trained by an experienced physiotherapist, had 24-hours online lessons. Students exposed to the same course in the previous five academic years (n = 112), delivered with face-to-face conventional lessons, served as a historical control. The course was organized in 3 sequential phases: (1) PowerPoint presentations were uploaded to the University online platform, (2) asynchronous video recorded lectures were provided on the same platform, and (3) between online lectures, the lecturer and students could communicate through an email chat to promote understanding, dispel any doubts and collect requests for supplementary material (e.g., scientific articles, videos, webinars, podcasts). Outcomes were: (1) satisfaction as routinely measured by University with a national instrument and populated in a database; (2) performance as measured with an oral examination.\n\nWe compared satisfaction with the course, expressed on a 5-point Likert scale, resulting in no differences between online and face-to-face teaching (Kruskal-Wallis 2 = 0.24, df = 1, p = 0.62). We weighted up students' results by comparing their mean performances with the mean performances of the same course delivered face-to-face in the previous five years, founding a statistical significance in favour of online teaching (Wilcoxon rank sum test W = 1665, p < 0.001).\n\nOnline teaching in entry-level Physiotherapy seems to be a feasible option to face COVID-19 pandemic, as satisfies students as well as face-to-face courses and leading to a similar performance. Entry-level Bachelors in Physiotherapy may consider moving to eLearning to facilitate access to higher education. Universities will have to train lecturers to help them develop appropriate pedagogical skills, and supply suitable support in terms of economic, organizational, and technological issues, aimed at guaranteeing a high level of education to their students.\n\nRetrospectively registered.", "doi": "10.1186/s12909-021-02896-1", "pmid": "34455979", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12909-021-02896-1"}], "notes": [], "created": "2021-09-01T07:44:05.171Z", "modified": "2021-09-01T07:44:05.184Z"}, {"entity": "publication", "iuid": "4bd928993ccb4b7b90cfbd024fc2beb7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4bd928993ccb4b7b90cfbd024fc2beb7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4bd928993ccb4b7b90cfbd024fc2beb7"}}, "title": "Knowledge, Attitude, Practice, and Fear of COVID-19: an Online-Based Cross-cultural Study.", "authors": [{"family": "Ali", "given": "Mohammad", "initials": "M", "orcid": "0000-0002-4685-5050", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7a7159c74bd4fe0b70772c0e38aca95.json"}}, {"family": "Uddin", "given": "Zakir", "initials": "Z", "orcid": "0000-0002-3018-0327", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4943eb54590d4da59a8e90294515693f.json"}}, {"family": "Banik", "given": "Palash Chandra", "initials": "PC", "orcid": "0000-0003-2395-9049", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bc92afccb2642cdab232cc1ad2713b1.json"}}, {"family": "Hegazy", "given": "Fatma A", "initials": "FA", "orcid": "0000-0001-7457-083X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0821210ae124134ba4e59520be0ef83.json"}}, {"family": "Zaman", "given": "Shamita", "initials": "S"}, {"family": "Ambia", "given": "Abu Saleh Mohammed", "initials": "ASM"}, {"family": "Siddique", "given": "Md Kaoser Bin", "initials": "MKB", "orcid": "0000-0002-0336-2694", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1514c69edd242c8adf9a56020e10e53.json"}}, {"family": "Islam", "given": "Rezoana", "initials": "R"}, {"family": "Khanam", "given": "Fatema", "initials": "F"}, {"family": "Bahalul", "given": "Sayed Mohammad", "initials": "SM"}, {"family": "Sharker", "given": "Md Ahiduzzaman", "initials": "MA"}, {"family": "Hossain", "given": "FMAkram", "initials": "F"}, {"family": "Ahsan", "given": "Gias U", "initials": "GU", "orcid": "0000-0003-0737-5940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41c88cf1b358432a89fa4817902223f6.json"}}], "type": "journal article", "published": "2021-08-30", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "pages": "1-16", "issn-l": null}, "abstract": "The study aimed to measure Knowledge, Attitude, and Practice (KAP) and fear level towards COVID-19 and explore its cross-cultural variances in knowledge by sociodemographic factors among the general population of 8 different countries over 5 continents. It was a cross-sectional online survey. This survey was conducted in April 2020 among 1296 participants using the \"Google Form\" platform. Considering the social distancing formula and pandemic situation, we collect data using popular social media networks. Univariate and bivariate analyses were used to explore the collected data on KAP, fear, and sociodemographic factors. Overall knowledge score was 9.7 \u00b1 1.7 (out of 12), and gender differences (female vs male: 9.8 \u00b1 1.6 vs 9.5 \u00b1 1.9) were significant (p = 0.008) in the bivariate analysis. Knowledge score variances were found significant in some regions by gender, marital status, and education qualification. The highest and lowest mean knowledge scores were recorded in the Middle East (10.0 \u00b1 1.7) and Europe (9.3 \u00b1 2.0). Despite having a high fear score (22.5 \u00b1 5.6 out of 35), 78.35% of respondents were positively and 81.7% in a good practice level. Fear score rankings: Middle East (1st; 23.8 \u00b1 5.5), Europe (2nd; 23.2 \u00b1 5.8), Africa (3rd; 22.7 \u00b1 5.0), South Asia (4th; 22.1 \u00b1 5.7), Oceania (5th; 21.9 \u00b1 5.8), and North America (6th; 21.7 \u00b1 5.5). Fear and knowledge were not correlated. KAP and fear variation exist among geographical regions. Gender, marital status, and education qualification are factors in knowledge variances for some regions. KAP and fear measures can help health education programs consider some sociodemographic factors and regions during an outbreak of highly contagious disease and uplift a positive attitude and good practice.\n\nThe online version contains supplementary material available at 10.1007/s11469-021-00638-4.", "doi": "10.1007/s11469-021-00638-4", "pmid": "34483782", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "638"}, {"db": "pmc", "key": "PMC8404540"}], "notes": [], "created": "2021-09-08T06:25:42.911Z", "modified": "2021-11-18T13:50:53.704Z"}, {"entity": "publication", "iuid": "e25282f83df94d9aaffc0240d8b3982f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e25282f83df94d9aaffc0240d8b3982f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e25282f83df94d9aaffc0240d8b3982f"}}, "title": "Influenza Vaccination after Myocardial Infarction: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial.", "authors": [{"family": "Fr\u00f8bert", "given": "Ole", "initials": "O"}, {"family": "G\u00f6tberg", "given": "Matthias", "initials": "M"}, {"family": "Erlinge", "given": "David", "initials": "D"}, {"family": "Akhtar", "given": "Zubair", "initials": "Z"}, {"family": "Christiansen", "given": "Evald H", "initials": "EH"}, {"family": "MacIntyre", "given": "Chandini R", "initials": "CR"}, {"family": "Oldroyd", "given": "Keith G", "initials": "KG"}, {"family": "Motovska", "given": "Zuzana", "initials": "Z"}, {"family": "Erglis", "given": "Andrejs", "initials": "A"}, {"family": "Moer", "given": "Rasmus", "initials": "R"}, {"family": "Hlinomaz", "given": "Ota", "initials": "O"}, {"family": "Jakobsen", "given": "Lars", "initials": "L"}, {"family": "Engstr\u00f8m", "given": "Thomas", "initials": "T"}, {"family": "Jensen", "given": "Lisette O", "initials": "LO"}, {"family": "Fallesen", "given": "Christian O", "initials": "CO"}, {"family": "Jensen", "given": "Svend E", "initials": "SE"}, {"family": "Anger\u00e5s", "given": "Oskar", "initials": "O"}, {"family": "Calais", "given": "Fredrik", "initials": "F"}, {"family": "K\u00e5regren", "given": "Amra", "initials": "A"}, {"family": "Lauermann", "given": "J\u00f6rg", "initials": "J"}, {"family": "Mokhtari", "given": "Arash", "initials": "A"}, {"family": "Nilsson", "given": "Johan", "initials": "J"}, {"family": "Persson", "given": "Jonas", "initials": "J"}, {"family": "Stalby", "given": "Per", "initials": "P"}, {"family": "Islam", "given": "Abu K M M", "initials": "AKMM"}, {"family": "Rahman", "given": "Afzalur", "initials": "A"}, {"family": "Malik", "given": "Fazila", "initials": "F"}, {"family": "Choudhury", "given": "Sohel", "initials": "S"}, {"family": "Collier", "given": "Timothy", "initials": "T"}, {"family": "Pocock", "given": "Stuart J", "initials": "SJ"}, {"family": "Pernow", "given": "John", "initials": "J"}], "type": "journal article", "published": "2021-08-30", "journal": {"title": "Circulation", "issn": "1524-4539", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Background: Observational and small randomized studies suggest that influenza vaccine may reduce future cardiovascular events in patients with cardiovascular disease. Methods: We conducted an investigator-initiated, randomized, double-blind trial to compare inactivated influenza vaccine with saline placebo administered shortly after myocardial infarction (MI) (99.7% of patients) or high-risk stable coronary heart disease (0.3%). The primary endpoint was the composite of all-cause death, MI, or stent thrombosis at 12 months. A hierarchical testing strategy was used for the key secondary endpoints: all-cause death, cardiovascular death, MI, and stent thrombosis. Results: Due to the Covid-19 pandemic, the data safety and monitoring board decided to halt the trial before attaining the prespecified sample size. Between October 1, 2016, and March 1, 2020, 2571 participants were randomized at 30 centers across eight countries; 1290 assigned to influenza vaccine and 1281 to placebo. Over the 12-month follow-up, the primary outcome occurred in 67 participants (5.3%) assigned influenza vaccine and 91 participants (7.2%) assigned placebo (hazard ratio, 0.72; 95% confidence interval, 0.52 to 0.99; P=0.040). Rates of all-cause death were 2.9% and 4.9% (hazard ratio, 0.59; 0.39 to 0.89; P=0.010), of cardiovascular death 2.7% and 4.5%, (hazard ratio, 0.59; 0.39 to 0.90; P=0.014), and of MI 2.0% and 2.4% (hazard ratio, 0.86; 0.50 to 1.46, P=0.57) in the influenza vaccine and placebo groups, respectively. Conclusions: Influenza vaccination early after an MI or in high-risk coronary heart disease resulted in a lower risk of a composite of all-cause death, MI, or stent thrombosis, as well as a lower risk of all-cause death and cardiovascular death at 12 months compared with placebo. Clinical Trial Registration: URL: http://www.clinicaltrials.gov Unique identifier: NCT02831608.", "doi": "10.1161/CIRCULATIONAHA.121.057042", "pmid": "34459211", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT02831608"}], "notes": [], "created": "2021-09-06T15:50:59.276Z", "modified": "2021-09-06T15:51:55.770Z"}, {"entity": "publication", "iuid": "b8ae0a7929a94a8591dce0de9bd1a1bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8ae0a7929a94a8591dce0de9bd1a1bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8ae0a7929a94a8591dce0de9bd1a1bd"}}, "title": "Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopes.", "authors": [{"family": "Gattinger", "given": "Pia", "initials": "P"}, {"family": "Niespodziana", "given": "Katarzyna", "initials": "K"}, {"family": "Stiasny", "given": "Karin", "initials": "K"}, {"family": "Sahanic", "given": "Sabina", "initials": "S"}, {"family": "Tulaeva", "given": "Inna", "initials": "I"}, {"family": "Borochova", "given": "Kristina", "initials": "K"}, {"family": "Dorofeeva", "given": "Yulia", "initials": "Y"}, {"family": "Schlederer", "given": "Thomas", "initials": "T"}, {"family": "Sonnweber", "given": "Thomas", "initials": "T"}, {"family": "Hofer", "given": "Gerhard", "initials": "G"}, {"family": "Kiss", "given": "Renata", "initials": "R"}, {"family": "Kratzer", "given": "Bernhard", "initials": "B"}, {"family": "Trapin", "given": "Doris", "initials": "D"}, {"family": "Tauber", "given": "Peter A", "initials": "PA"}, {"family": "Rottal", "given": "Arno", "initials": "A"}, {"family": "K\u00f6rm\u00f6czi", "given": "Ulrike", "initials": "U"}, {"family": "Feichter", "given": "Melanie", "initials": "M"}, {"family": "Weber", "given": "Milena", "initials": "M"}, {"family": "Focke-Tejkl", "given": "Margarete", "initials": "M"}, {"family": "L\u00f6ffler-Ragg", "given": "Judith", "initials": "J"}, {"family": "M\u00fchl", "given": "Bernhard", "initials": "B"}, {"family": "Kropfm\u00fcller", "given": "Anna", "initials": "A"}, {"family": "Keller", "given": "Walter", "initials": "W"}, {"family": "Stolz", "given": "Frank", "initials": "F"}, {"family": "Henning", "given": "Rainer", "initials": "R"}, {"family": "Tancevski", "given": "Ivan", "initials": "I"}, {"family": "Puchhammer-St\u00f6ckl", "given": "Elisabeth", "initials": "E"}, {"family": "Pickl", "given": "Winfried F", "initials": "WF"}, {"family": "Valenta", "given": "Rudolf", "initials": "R"}], "type": "journal article", "published": "2021-08-28", "journal": {"title": "Allergy", "issn": "1398-9995", "issn-l": "0105-4538", "volume": null, "issue": null, "pages": null}, "abstract": "The determinants of successful humoral immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of critical importance for the design of effective vaccines and the evaluation of the degree of protective immunity conferred by exposure to the virus. As novel variants emerge, understanding their likelihood of suppression by population antibody repertoires has become increasingly important.\r\n\r\nIn this study we analysed the SARS-CoV-2 polyclonal antibody response in a large population of clinically well-characterized patients after mild and severe COVID-19 using a panel of microarrayed structurally folded and unfolded SARS-CoV-2 proteins, as well as sequential peptides, spanning the surface spike protein (S) and the receptor-binding domain (RBD) of the virus.\r\n\r\nS- and RBD-specific antibody responses were dominated by immunoglobulin G (IgG), mainly IgG1 , and directed against structurally folded S and RBD and three distinct peptide epitopes in S2. The virus-neutralization activity of patients\u00b4 sera was highly correlated with IgG antibodies specific for conformational but not sequential RBD epitopes and their ability to prevent RBD binding to its human receptor angiotensin-converting enzyme 2 (ACE2). Twenty percent of patients selectively lacked RBD-specific IgG. Only immunisation with folded, but not with unfolded RBD, induced antibodies against conformational epitopes with high virus-neutralizing activity. Conformational RBD epitopes required for protection do not seem to be altered in the currently emerging virus variants.\r\n\r\nThese results are fundamental for estimating the protective activity of antibody responses after natural infection or vaccination and for the design of vaccines, which can induce high levels of SARS-CoV-2-neutralizing antibodies conferring sterilizing immunity.", "doi": "10.1111/all.15066", "pmid": "34453317", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-09-01T07:34:03.895Z", "modified": "2021-09-01T07:35:00.011Z"}, {"entity": "publication", "iuid": "4720c066c4634d349e89e6e2482949e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4720c066c4634d349e89e6e2482949e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4720c066c4634d349e89e6e2482949e8"}}, "title": "Landscape of T-cell repertoires with public COVID-19-associated T-cell receptors in pre-pandemic risk cohorts.", "authors": [{"family": "Simnica", "given": "Donjete", "initials": "D", "orcid": "0000-0003-2286-1381", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ba6674f733f45a19f092396b7134252.json"}}, {"family": "Schulthei\u00df", "given": "Christoph", "initials": "C", "orcid": "0000-0001-9789-5776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88027bf0a4314e958d8bcf7016d8ddfc.json"}}, {"family": "Mohme", "given": "Malte", "initials": "M"}, {"family": "Paschold", "given": "Lisa", "initials": "L"}, {"family": "Willscher", "given": "Edith", "initials": "E"}, {"family": "Fitzek", "given": "Antonia", "initials": "A"}, {"family": "P\u00fcschel", "given": "Klaus", "initials": "K"}, {"family": "Matschke", "given": "Jakob", "initials": "J"}, {"family": "Ciesek", "given": "Sandra", "initials": "S"}, {"family": "Sedding", "given": "Daniel G", "initials": "DG"}, {"family": "Zhao", "given": "Yu", "initials": "Y", "orcid": "0000-0003-2632-7530", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c46abe67678044d88ed9313bb26819fe.json"}}, {"family": "Gagliani", "given": "Nicola", "initials": "N"}, {"family": "Maringer", "given": "Yacine", "initials": "Y"}, {"family": "Walz", "given": "Juliane S", "initials": "JS"}, {"family": "Heide", "given": "Janna", "initials": "J"}, {"family": "Schulze-Zur-Wiesch", "given": "Julian", "initials": "J"}, {"family": "Binder", "given": "Mascha", "initials": "M"}], "type": "journal article", "published": "2021-08-28", "journal": {"title": "Clin Transl Immunol", "issn": "2050-0068", "volume": "10", "issue": "9", "pages": "e1340", "issn-l": null}, "abstract": "T cells have an essential role in the antiviral defence. Public T-cell receptor (TCR) clonotypes are expanded in a substantial proportion of COVID-19 patients. We set out to exploit their potential use as read-out for COVID-19 T-cell immune responses.\n\nWe searched for COVID-19-associated T-cell clones with public TCRs, as defined by identical complementarity-determining region 3 (CDR3) beta chain amino acid sequence that can be reproducibly detected in the blood of COVID-19 patients. Of the different clonotype identification algorithms used in this study, deep sequencing of brain tissue of five patients with fatal COVID-19 delivered 68 TCR clonotypes with superior representation across 140 immune repertoires of unrelated COVID-19 patients.\n\nMining of immune repertoires from subjects not previously exposed to the virus showed that these clonotypes can be found in almost 20% of pre-pandemic immune repertoires of healthy subjects, with lower representation in repertoires from risk groups like individuals above the age of 60 years or patients with cancer.\n\nTogether, our data show that at least a proportion of the SARS-CoV-2 T-cell response is mediated by public TCRs that are present in repertoires of unexposed individuals. The lower representation of these clones in repertoires of risk groups or failure to expand such clones may contribute to more unfavorable clinical COVID-19 courses.", "doi": "10.1002/cti2.1340", "pmid": "34484739", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "CTI21340"}, {"db": "pmc", "key": "PMC8401425"}, {"db": "URL", "key": "https://gateway.ireceptor.org", "description": "AIRR-seq data (iReceptor Study ID IR-Binder-000001)"}, {"db": "URL", "key": "https://www.ebi.ac.uk/ena/browser/view/PRJEB38339?show=reads", "description": "Sequence data in ENA (Project: PRJEB38339)"}], "notes": [], "created": "2021-09-08T06:33:45.029Z", "modified": "2021-09-09T07:17:55.696Z"}, {"entity": "publication", "iuid": "527e3f4b97ac4d2b9894a63183be6e57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/527e3f4b97ac4d2b9894a63183be6e57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/527e3f4b97ac4d2b9894a63183be6e57"}}, "title": "\"We Thought We Were Prepared, but We Were Not\": Experiences from the Management of the Psychosocial Support Response during the COVID-19 Pandemic in Sweden. A Mixed-Methods Study.", "authors": [{"family": "Hugelius", "given": "Karin", "initials": "K", "orcid": "0000-0003-0534-4593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f7d4e9ff0f645598a2473e42806066a.json"}}, {"family": "Johansson", "given": "Sara", "initials": "S"}, {"family": "Sj\u00f6lin", "given": "Helena", "initials": "H"}], "type": "journal article", "published": "2021-08-28", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "17", "pages": null}, "abstract": "This study aimed to describe experiences of managing mental health and psychosocial activities during the first six months of the COVID-19 pandemic in Sweden. A national survey was answered by a non-probability sample of 340 involved in the psychosocial response. The psychosocial response operations met several challenges, mainly related to the diverse actors involved, lack of competence, and lack of preparations. Less than 20% of the participants had received specific training in the provision of psychosocial support during major incidents. The interventions used varied, and no large-scale interventions were used. The psychosocial response organizations were overwhelmed by the needs of health care staff and failed to meet the needs of patients and family members. An efficient and durable psychosocial response in a long-term crisis requires to be structured, planned and well-integrated into the overall pandemic response. All personnel involved need adequate and specific competence in evidence-based individual and large-scale interventions to provide psychosocial support in significant incidents. By increasing general awareness of mental wellbeing and psychosocial support amongst health professionals and their first-line managers, a more resilient health care system, both in everyday life and during major incidents and disasters, could be facilitated.", "doi": "10.3390/ijerph18179079", "pmid": "34501668", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph18179079"}], "notes": [], "created": "2021-09-13T06:08:21.348Z", "modified": "2021-11-18T13:49:38.010Z"}, {"entity": "publication", "iuid": "e707bb01f3554d2fa9ef5b495830bdad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e707bb01f3554d2fa9ef5b495830bdad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e707bb01f3554d2fa9ef5b495830bdad"}}, "title": "The clinical association between Periodontitis and COVID-19.", "authors": [{"family": "Gupta", "given": "Shipra", "initials": "S", "orcid": "0000-0003-2097-2459", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa6dd4cea3824827b3ead550b8267b2a.json"}}, {"family": "Mohindra", "given": "Ritin", "initials": "R"}, {"family": "Singla", "given": "Mohita", "initials": "M"}, {"family": "Khera", "given": "Sagar", "initials": "S"}, {"family": "Sahni", "given": "Vaibhav", "initials": "V"}, {"family": "Kanta", "given": "Poonam", "initials": "P"}, {"family": "Soni", "given": "Roop Kishor", "initials": "RK"}, {"family": "Kumar", "given": "Amit", "initials": "A"}, {"family": "Gauba", "given": "Krishan", "initials": "K"}, {"family": "Goyal", "given": "Kapil", "initials": "K"}, {"family": "Singh", "given": "Mini P", "initials": "MP"}, {"family": "Ghosh", "given": "Arnab", "initials": "A"}, {"family": "Kajal", "given": "Kamal", "initials": "K"}, {"family": "Mahajan", "given": "Varun", "initials": "V"}, {"family": "Bhalla", "given": "Ashish", "initials": "A"}, {"family": "Sorsa", "given": "Timo", "initials": "T"}, {"family": "R\u00e4is\u00e4nen", "given": "Ismo", "initials": "I"}], "type": "journal article", "published": "2021-08-27", "journal": {"title": "Clin Oral Investig", "issn": "1436-3771", "issn-l": null}, "abstract": "The study aimed to clinically assess the association between periodontitis and COVID-19-related outcomes.\n\nData pertaining to patient demographics, medical history, blood parameters, periodontal clinical examination and aMMP-8 point-of-care diagnostics (both site-level and patient-level) was recorded for eighty-two COVID-19-positive patients. COVID-19-related outcomes such as COVID-19 pneumonia, death/survival, types of hospital admission and need of assisted ventilation were also assessed.\n\nMales were predominantly afflicted with COVID-19, with advanced age exhibiting a greater association with the presence of periodontitis. Higher severity of periodontitis led to 7.45 odds of requiring assisted ventilation, 36.52 odds of hospital admission, 14.58 odds of being deceased and 4.42 odds of COVID-19-related pneumonia. The aMMP-8 mouthrinse kit was slightly more sensitive but less specific than aMMP-8 site-specific tests.\n\nBased on the findings of the present study, periodontitis seems to be related to poorer COVID-19-related outcomes. However, within the constraints of this work, a direct causality may not be established. Periodontitis, by means of skewing the systemic condition for a number of comorbidities, may eventually influence COVID-19 outcomes in an indirect manner.\n\nThe study is the first to clinically, and by means of a validated point-of-care diagnostic methodology, assess the association between periodontal health and COVID-19-related outcomes. Assessment of the periodontal status of individuals can aid in the identification of risk groups during the pandemic along with reinforcing the need to maintain oral hygiene and seeking periodontal care.", "doi": "10.1007/s00784-021-04111-3", "pmid": "34448073", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00784-021-04111-3"}, {"db": "pmc", "key": "PMC8390180"}], "notes": [], "created": "2021-09-01T07:29:31.641Z", "modified": "2021-09-01T07:29:31.688Z"}, {"entity": "publication", "iuid": "064027b6251c4ed792919419795510de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/064027b6251c4ed792919419795510de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/064027b6251c4ed792919419795510de"}}, "title": "SARS-CoV-2 Antibody Isotypes in Systemic Lupus Erythematosus Patients Prior to Vaccination: Associations With Disease Activity, Antinuclear Antibodies, and Immunomodulatory Drugs During the First Year of the Pandemic.", "authors": [{"family": "Sj\u00f6wall", "given": "Johanna", "initials": "J"}, {"family": "Azharuddin", "given": "Mohammad", "initials": "M"}, {"family": "Frodlund", "given": "Martina", "initials": "M"}, {"family": "Zhang", "given": "Yuming", "initials": "Y"}, {"family": "Sandner", "given": "Laura", "initials": "L"}, {"family": "Dahle", "given": "Charlotte", "initials": "C"}, {"family": "Hinkula", "given": "Jorma", "initials": "J"}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C"}], "type": "journal article", "published": "2021-08-27", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "12", "pages": "724047", "issn-l": "1664-3224"}, "abstract": "Impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic on individuals with arthritis has been highlighted whereas data on other rheumatic diseases, e.g., systemic lupus erythematosus (SLE), are scarce. Similarly to SLE, severe SARS-CoV-2 infection includes risks for thromboembolism, an unbalanced type I interferon response, and complement activation. Herein, SARS-CoV-2 antibodies in longitudinal samples collected prior to vaccination were analyzed and compared with SLE progression and antinuclear antibody (ANA) levels.\n\nOne hundred patients (83 women) with established SLE and a regular visit to the rheumatologist (March 2020 to January 2021) were included. All subjects donated blood and had done likewise prior to the pandemic. SARS-CoV-2 antibody isotypes (IgG, IgA, IgM) to the cell receptor-binding S1-spike outer envelope protein were detected by ELISA, and their neutralizing capacity was investigated. IgG-ANA were measured by multiplex technology.\n\nDuring the pandemic, 4% had PCR-confirmed infection but 36% showed SARS-CoV-2 antibodies of \u22651 isotype; IgA was the most common (30%), followed by IgM (9%) and IgG (8%). The antibodies had low neutralizing capacity and were detected also in prepandemic samples. Plasma albumin (p = 0.04) and anti-dsDNA (p = 0.003) levels were lower in patients with SARS-CoV-2 antibodies. Blood group, BMI, smoking habits, complement proteins, daily glucocorticoid dose, use of hydroxychloroquine, or self-reported coronavirus disease 2019 (COVID-19) symptoms (except fever, >38.5\u00b0C) did not associate with SARS-CoV-2 antibodies.\n\nOur data from early 2021 indicate that a large proportion of Swedish SLE patients had serological signs of exposure to SARS-CoV-2 but apparently with a minor impact on the SLE course. Use of steroids and hydroxychloroquine showed no distinct effects, and self-reported COVID-19-related symptoms correlated poorly with all antibody isotypes.", "doi": "10.3389/fimmu.2021.724047", "pmid": "34512651", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8430325"}], "notes": [], "created": "2021-09-20T06:34:23.895Z", "modified": "2023-06-19T15:35:17.591Z"}, {"entity": "publication", "iuid": "99548417cab34ceeb2290d9011bc64f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/99548417cab34ceeb2290d9011bc64f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/99548417cab34ceeb2290d9011bc64f4"}}, "title": "Post-traumatic stress disorder (PTSD) in parents of children with type 1 diabetes during Covid-19 pandemic.", "authors": [{"family": "Carducci", "given": "C", "initials": "C"}, {"family": "Rapini", "given": "N", "initials": "N"}, {"family": "Deodati", "given": "A", "initials": "A"}, {"family": "Pampanini", "given": "V", "initials": "V"}, {"family": "Cianfarani", "given": "S", "initials": "S"}, {"family": "Schiaffini", "given": "R", "initials": "R", "orcid": "0000-0002-9527-2353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5246b36ef614d9fb2ceb112e0cd80ba.json"}}], "type": "journal article", "published": "2021-08-26", "journal": {"title": "Ital J Pediatr", "issn": "1824-7288", "issn-l": null, "volume": "47", "issue": "1", "pages": "176"}, "abstract": "The Post-traumatic Stress Disorder (PTSD) is a group of persistent psychological and physiological symptoms due to a traumatic, severe, event. Only few studies focused on the effects of Covid-19 on psychosocial outcomes in children with Type 1 Diabetes (T1D) and their parents.\r\n\r\nThe aim of this study was to evaluate the presence PTSD in parents of children with T1D during COVID-19 pandemic lockdown.\r\n\r\nIn the period between March and May 2020 we submitted the \"Impact of Event Scale - Revised\" (IES-R) questionnaire to the parents of 34 children with Type 1 Diabetes, asking them to express their emotions about the ongoing Covid-19 pandemic.\r\n\r\nA total of thirty mothers (mean age 43.0 \u00b1 4.2 years) and 25 fathers (mean age 45.6 \u00b1 5.9 years) participated in the survey and completed the questionnaires. 29.1% of parents had a score that allows to define a clinically relevant level of PTSD; ten mothers and 6 fathers had a PTSD clinically relevant score, corresponding, respectively, to 28.4 and 24% of total mothers and fathers. Finally, mothers and fathers, both express PTSD symptoms mainly in the form of intrusion and hyperarousal.\r\n\r\nThe present study confirms a high prevalence symptoms related to PTSD in mothers and fathers of children with Type 1 Diabetes. We believe that psychosocial outcomes of the COVID-19 pandemic should be taken into account in the planning of the next future assistance for children with T1D.", "doi": "10.1186/s13052-021-01126-0", "pmid": "34446073", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13052-021-01126-0"}, {"db": "pmc", "key": "PMC8390018"}], "notes": [], "created": "2021-09-01T07:28:55.218Z", "modified": "2021-11-18T13:41:46.716Z"}, {"entity": "publication", "iuid": "47162541ac884a13b88bd4f57d46d617", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47162541ac884a13b88bd4f57d46d617.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47162541ac884a13b88bd4f57d46d617"}}, "title": "Evening-types show highest increase of sleep and mental health problems during the COVID-19 pandemic - Multinational study on 19,267 adults.", "authors": [{"family": "Merikanto", "given": "Ilona", "initials": "I", "orcid": "0000-0002-1222-6678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/50ed32f3146e4c0aa13e934d46eeb4af.json"}}, {"family": "Kortesoja", "given": "Laura", "initials": "L"}, {"family": "Benedict", "given": "Christian", "initials": "C", "orcid": "0000-0002-8911-4068", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a61aee14ada46ce968c40c652ac72df.json"}}, {"family": "Chung", "given": "Frances", "initials": "F"}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J"}, {"family": "Espie", "given": "Colin A", "initials": "CA"}, {"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y", "orcid": "0000-0003-0683-6506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/630f66dea3ce4ff2afe3c46f7827355b.json"}}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L", "orcid": "0000-0003-3613-6631", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e700e607f114414dba66aa366e3158b6.json"}}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK"}, {"family": "Chan", "given": "Ngan Yin", "initials": "NY"}, {"family": "Inoue", "given": "Yuichi", "initials": "Y"}, {"family": "Matsui", "given": "Kentaro", "initials": "K"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Plazzi", "given": "Giuseppe", "initials": "G"}, {"family": "Mota-Rolim", "given": "S\u00e9rgio Arthuro", "initials": "SA"}, {"family": "Leger", "given": "Damien", "initials": "D"}, {"family": "Penzel", "given": "Thomas", "initials": "T", "orcid": "0000-0002-4304-0112", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0dc4e472c71460ab792f74bc8163a9a.json"}}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}], "type": "journal article", "published": "2021-08-25", "journal": {"issn": "1550-9109", "title": "Sleep", "issn-l": null}, "abstract": "Individual circadian type is a ubiquitous trait defining sleep, with eveningness often associated with poorer sleep and mental health than morningness. However, it is unknown whether COVID-19 pandemic has differentially affected sleep and mental health depending on the circadian type. Here, the differences in sleep and mental health between circadian types are examined globally before and during the COVID-19 pandemic.\n\nThe sample collected between May and August 2020 across 12 countries/regions consisted of 19,267 adults with information on their circadian type. Statistical analyses were performed by using Complex Sample procedures, stratified by country and weighted by the number of inhabitants in the country/area of interest and by the relative number of responders in that country/area.\n\nEvening-types had poorer mental health, well-being, and quality of life or health than other circadian types during the pandemic. Sleep-wake schedules were delayed especially on working days, and evening-types reported an increase in sleep duration. Sleep problems increased in all circadian types, but especially among evening-types, moderated by financial suffering and confinement. Intermediate-types were less vulnerable to sleep changes, although morningness protected from most sleep problems. These findings were confirmed after adjusting for age, sex, duration of the confinement or socio-economic status during the pandemic.\n\nThese findings indicate an alarming increase in sleep and mental health problems, especially among evening-types as compared to other circadian types during the pandemic.", "doi": "10.1093/sleep/zsab216", "pmid": "34432058", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6357297"}], "notes": [], "created": "2021-08-27T09:36:22.035Z", "modified": "2021-09-01T07:19:56.356Z"}, {"entity": "publication", "iuid": "70f55448c66a4a86b18adc2a11d6b260", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70f55448c66a4a86b18adc2a11d6b260.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70f55448c66a4a86b18adc2a11d6b260"}}, "title": "Testing indicators to monitor the COVID-19 pandemic.", "authors": [{"family": "Beaut\u00e9", "given": "Julien", "initials": "J"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "Spiteri", "given": "Gianfranco", "initials": "G"}], "type": "journal article", "published": "2021-08-24", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "issn-l": null}, "abstract": null, "doi": "10.1016/S1473-3099(21)00461-8", "pmid": "34450053", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(21)00461-8"}, {"db": "pmc", "key": "PMC8384351"}], "notes": [], "created": "2021-09-01T07:31:54.529Z", "modified": "2021-09-01T07:32:45.430Z"}, {"entity": "publication", "iuid": "7720ddb00d1f45708a974b7bb249483f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7720ddb00d1f45708a974b7bb249483f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7720ddb00d1f45708a974b7bb249483f"}}, "title": "Skin Exposures, Hand Eczema and Facial Skin Disease in Healthcare Workers During the COVID-19 Pandemic: A Cross-sectional Study.", "authors": [{"family": "Hamnerius", "given": "Nils", "initials": "N"}, {"family": "Pont\u00e9n", "given": "Ann", "initials": "A"}, {"family": "Bergendorff", "given": "Ola", "initials": "O"}, {"family": "Bruze", "given": "Magnus", "initials": "M"}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}, {"family": "Svedman", "given": "Cecilia", "initials": "C"}], "type": "journal article", "published": "2021-08-24", "journal": {"title": "Acta Derm Venereol", "issn": "1651-2057", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic has led to enhanced hygiene procedures and use of personal protective equipment, but also to increased attention to occupational skin disease in healthcare workers. The occurrence of hand and facial skin disease in > 5,000 Swedish healthcare workers was investigated in a questionnaire survey. Levels of skin exposure related to hygiene procedures and personal protective equipment were recorded. Caring for patients with COVID-19 entailed higher levels of wet work and face mask exposures, and was associated with higher 1-year prevalence of both hand eczema (36%) and facial skin disease (32%) compared with not being directly engaged in COVID-19 care (28% and 22%, respectively). Acne and eczema were the most common facial skin diseases; for both, a dose-dependent association with face mask use was found. Dose-dependent associations could be shown between hand eczema and exposure to soap and gloves, but not to alcohol-based hand disinfectants.", "doi": "10.2340/00015555-3904", "pmid": "34427318", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-27T09:37:42.140Z", "modified": "2021-09-01T07:23:18.951Z"}, {"entity": "publication", "iuid": "b1018af9509f47b19a78984fd97f69b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1018af9509f47b19a78984fd97f69b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1018af9509f47b19a78984fd97f69b2"}}, "title": "Editorial: Coronavirus Disease (COVID-19): The Impact and Role of Mass Media During the Pandemic.", "authors": [{"family": "Arriaga", "given": "Patr\u00edcia", "initials": "P"}, {"family": "Esteves", "given": "Francisco", "initials": "F"}, {"family": "Pavlova", "given": "Marina A", "initials": "MA"}, {"family": "Pi\u00e7arra", "given": "Nuno", "initials": "N"}], "type": "editorial", "published": "2021-08-23", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "729238", "issn-l": "1664-1078"}, "abstract": null, "doi": "10.3389/fpsyg.2021.729238", "pmid": "34497569", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8419265"}], "notes": [], "created": "2021-09-13T06:07:06.587Z", "modified": "2021-09-13T06:07:06.599Z"}, {"entity": "publication", "iuid": "63efea786d524e588aa3cca55dc76b1a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63efea786d524e588aa3cca55dc76b1a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63efea786d524e588aa3cca55dc76b1a"}}, "title": "Suicide by gender and 10-year age groups during the COVID-19 pandemic vs previous five years in Japan: An analysis of national vital statistics.", "authors": [{"family": "Eguchi", "given": "Akifumi", "initials": "A"}, {"family": "Nomura", "given": "Shuhei", "initials": "S"}, {"family": "Gilmour", "given": "Stuart", "initials": "S"}, {"family": "Harada", "given": "Nahoko", "initials": "N"}, {"family": "Sakamoto", "given": "Haruka", "initials": "H"}, {"family": "Ueda", "given": "Peter", "initials": "P"}, {"family": "Yoneoka", "given": "Daisuke", "initials": "D"}, {"family": "Tanoue", "given": "Yuta", "initials": "Y"}, {"family": "Kawashima", "given": "Takayuki", "initials": "T"}, {"family": "Hayashi", "given": "Takehiko I", "initials": "TI"}, {"family": "Arima", "given": "Yuzo", "initials": "Y"}, {"family": "Suzuki", "given": "Motoi", "initials": "M"}, {"family": "Hashizume", "given": "Masahiro", "initials": "M"}], "type": "journal article", "published": "2021-08-21", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "issn-l": null, "volume": "305", "issue": null, "pages": "114173"}, "abstract": "Using daily vital statistics data from the Japanese Ministry of Health, Labour and Welfare, we provide the first weekly and age-group-specific estimates of the additional suicide burden during the COVID-19 pandemic in Japan by gender, from January through November 2020. Our results indicate that compared with the previous five years, suicide cases in 2020 in Japan have increased from late July to November for women in all age groups and for men in the 20-29 and 80+ years age group. Targeted interventions based on age and gender might be more effective in reducing suicide during the COVID-19 pandemic in Japan.", "doi": "10.1016/j.psychres.2021.114173", "pmid": "34469804", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(21)00469-8"}], "notes": [], "created": "2021-09-06T06:18:57.351Z", "modified": "2022-11-23T08:53:26.049Z"}, {"entity": "publication", "iuid": "faf9cbc5033b47729c3640abd68177d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/faf9cbc5033b47729c3640abd68177d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/faf9cbc5033b47729c3640abd68177d9"}}, "title": "Internet-based stress recovery intervention FOREST for healthcare staff amid COVID-19 pandemic: study protocol for a randomized controlled trial.", "authors": [{"family": "Jovarauskaite", "given": "Lina", "initials": "L", "orcid": "0000-0002-8043-3003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d280b0d3947b4fb692053a571e4c593f.json"}}, {"family": "Dumarkaite", "given": "Austeja", "initials": "A"}, {"family": "Truskauskaite-Kuneviciene", "given": "Inga", "initials": "I"}, {"family": "Jovaisiene", "given": "Ieva", "initials": "I"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Kazlauskas", "given": "Evaldas", "initials": "E"}], "type": "clinical trial protocol", "published": "2021-08-21", "journal": {"title": "Trials", "issn": "1745-6215", "issn-l": null, "volume": "22", "issue": "1", "pages": "559"}, "abstract": "The demand for care during the COVID-19 pandemic has affected the mental health of healthcare workers (HCWs), thus increasing the need for psychosocial support services. Internet-based interventions have previously been found to reduce occupational stress. The study aims to test the effects of an Internet-based stress recovery intervention-FOREST-among HCWs.\r\n\r\nA randomized controlled trial (RCT) parallel group design with three measurement points will be conducted to assess the efficacy of an Internet-based stress recovery intervention FOREST for nurses. The FOREST intervention is a 6-week Internet-based CBT and mindfulness-based program which comprises of six modules: (1) Introduction, (2) Detachment (relaxation and sleep), (3) Distancing, (4) Mastery (challenge), (5) Control, and (6) Keeping the change alive. We will compare the intervention against a waiting list group at pre-test, post-test, and follow-up. Stress recovery, PTSD, complex PTSD, moral injury, the level of stress, depression, anxiety, and psychological well-being will be measured.\r\n\r\nThe study will contribute to the development of mental healthcare programs for the HCWs. Based on the outcomes of the study, the FOREST intervention can be further developed or offered to healthcare staff as a tool to cope with occupational stress.\r\n\r\nClinicalTrials.gov NCT04817995 . Registered on 30 March 2021.", "doi": "10.1186/s13063-021-05512-1", "pmid": "34419114", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13063-021-05512-1"}, {"db": "pmc", "key": "PMC8380103"}, {"db": "ClinicalTrials.gov", "key": "NCT04817995"}], "notes": [], "created": "2021-08-27T09:43:36.718Z", "modified": "2021-11-18T13:40:03.339Z"}, {"entity": "publication", "iuid": "21a5b0f2d8f14c15adaef521bb5ffb75", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/21a5b0f2d8f14c15adaef521bb5ffb75.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/21a5b0f2d8f14c15adaef521bb5ffb75"}}, "title": "A Global Survey of Emergency Department Responses to the COVID-19 Pandemic.", "authors": [{"family": "Mahajan", "given": "Prashant", "initials": "P"}, {"family": "Shu-Ling", "given": "Chong", "initials": "C"}, {"family": "Gutierrez", "given": "Camilo", "initials": "C"}, {"family": "White", "given": "Emily", "initials": "E"}, {"family": "Cher", "given": "Benjamin A Y", "initials": "BAY"}, {"family": "Freiheit", "given": "Elizabeth", "initials": "E"}, {"family": "Belle", "given": "Apoorva", "initials": "A"}, {"family": "EMERGE NETWORK", "given": "", "initials": ""}, {"family": "Kaartinen", "given": "Johanna", "initials": "J"}, {"family": "Kumar", "given": "Vijaya Arun", "initials": "VA"}, {"family": "Middleton", "given": "Paul M", "initials": "PM"}, {"family": "Ng", "given": "Chip Jin", "initials": "CJ"}, {"family": "Osei-Kwame", "given": "Daniel", "initials": "D"}, {"family": "Roth", "given": "Dominik", "initials": "D"}, {"family": "Sinja", "given": "Tej Prakash", "initials": "TP"}, {"family": "Galwankar", "given": "Sagar", "initials": "S"}, {"family": "Nypaver", "given": "Michele", "initials": "M"}, {"family": "Kuppermann", "given": "Nathan", "initials": "N"}, {"family": "EKelund", "given": "Ulf", "initials": "U"}], "type": "journal article", "published": "2021-08-21", "journal": {"title": "West J Emerg Med", "issn": "1936-9018", "volume": "22", "issue": "5", "pages": "1037-1044", "issn-l": null}, "abstract": "Emergency departments (ED) globally are addressing the coronavirus disease 2019 (COVID-19) pandemic with varying degrees of success. We leveraged the 17-country, Emergency Medicine Education & Research by Global Experts (EMERGE) network and non-EMERGE ED contacts to understand ED emergency preparedness and practices globally when combating the COVID-19 pandemic.\n\nWe electronically surveyed EMERGE and non-EMERGE EDs from April 3-June 1, 2020 on ED capacity, pandemic preparedness plans, triage methods, staffing, supplies, and communication practices. The survey was available in English, Mandarin Chinese, and Spanish to optimize participation. We analyzed survey responses using descriptive statistics.\n\n74/129 (57%) EDs from 28 countries in all six World Health Organization global regions responded. Most EDs were in Asia (49%), followed by North America (28%), and Europe (14%). Nearly all EDs (97%) developed and implemented protocols for screening, testing, and treating patients with suspected COVID-19 infections. Sixty percent responded that provider staffing/back-up plans were ineffective. Many sites (47/74, 64%) reported staff missing work due to possible illness with the highest provider proportion of COVID-19 exposures and infections among nurses.\n\nDespite having disaster plans in place, ED pandemic preparedness and response continue to be a challenge. Global emergency research networks are vital for generating and disseminating large-scale event data, which is particularly important during a pandemic.", "doi": "10.5811/westjem.2021.3.50358", "pmid": "34546878", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "westjem.2021.3.50358"}, {"db": "pmc", "key": "PMC8463065"}], "notes": [], "created": "2021-10-27T05:11:48.877Z", "modified": "2021-10-27T05:11:48.912Z"}, {"entity": "publication", "iuid": "6a507045616541839ab2f403d1f0b1f5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a507045616541839ab2f403d1f0b1f5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a507045616541839ab2f403d1f0b1f5"}}, "title": "Unexpected details regarding nosocomial transmission revealed by whole-genome sequencing of severe acute respiratory coronavirus virus 2 (SARS-CoV-2).", "authors": [{"family": "Myhrman", "given": "Sofia", "initials": "S", "orcid": "0000-0002-2954-1260", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff2d7f2219e24cc39a96bb4e113b8e54.json"}}, {"family": "Olausson", "given": "Josefin", "initials": "J"}, {"family": "Ringlander", "given": "Johan", "initials": "J"}, {"family": "Gustavsson", "given": "Lin\u00e9a", "initials": "L"}, {"family": "Jakobsson", "given": "Hedvig E", "initials": "HE"}, {"family": "Sansone", "given": "Martina", "initials": "M"}, {"family": "Westin", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2021-08-20", "journal": {"title": "Infect Control Hosp Epidemiol", "issn": "1559-6834", "pages": "1-5", "issn-l": "0899-823X"}, "abstract": "Effective infection prevention and control (IPC) measures are key for protecting patients from nosocomial infections and require knowledge of transmission mechanisms in different settings. We performed a detailed outbreak analysis of the transmission and outcome of coronavirus disease 2019 (COVID-19) in a geriatric ward by combining whole-genome sequencing (WGS) with epidemiological data.\n\nRetrospective cohort study.\n\nTertiary-care hospital.\n\nPatients and healthcare workers (HCWs) from the ward with a nasopharyngeal sample (NPS) positive for severe acute respiratory coronavirus virus 2 (SARS-CoV-2) RNA during the outbreak period.\n\nPatient data regarding clinical characteristics, exposure and outcome were collected retrospectively from medical records. Stored NPSs from 32 patients and 15 HCWs were selected for WGS and phylogenetic analysis.\n\nThe median patient age was 84 years and 17 (53%) of 32 were male. Also, 14 patients (44%) died within 30 days of sampling. Viral loads were significantly higher among the deceased. WGS was successful in 28 (88%) of 32 patient samples and 14 (93%) of 15 HCW samples. Moreover, 3 separate viral clades were identified: 1 clade and 2 subclades among both patient and HCW samples. Integrated epidemiological and genetic analyses revealed 6 probable transmission events between patients and supported hospital-acquired COVID-19 among 25 of 32 patients.\n\nWGS provided an insight into the outbreak dynamics and true extent of nosocomial COVID-19. The extensive transmission between patients and HCWs indicated that current IPC measures were insufficient. We recommend increased use of WGS in outbreak investigations to identify otherwise unknown transmission links and to evaluate IPC measures.", "doi": "10.1017/ice.2021.374", "pmid": "34496989", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0899823X21003743"}], "notes": [], "created": "2021-09-13T06:06:19.296Z", "modified": "2021-09-13T06:06:19.338Z"}, {"entity": "publication", "iuid": "5c63ba50a60041fd80e0adc526bb1f27", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c63ba50a60041fd80e0adc526bb1f27.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c63ba50a60041fd80e0adc526bb1f27"}}, "title": "Axillary lymphadenopathy at the time of COVID-19 vaccination: ten recommendations from the European Society of Breast Imaging (EUSOBI).", "authors": [{"family": "Schiaffino", "given": "Simone", "initials": "S"}, {"family": "Pinker", "given": "Katja", "initials": "K"}, {"family": "Magni", "given": "Veronica", "initials": "V"}, {"family": "Cozzi", "given": "Andrea", "initials": "A"}, {"family": "Athanasiou", "given": "Alexandra", "initials": "A"}, {"family": "Baltzer", "given": "Pascal A T", "initials": "PAT"}, {"family": "Camps Herrero", "given": "Julia", "initials": "J"}, {"family": "Clauser", "given": "Paola", "initials": "P"}, {"family": "Fallenberg", "given": "Eva M", "initials": "EM"}, {"family": "Forrai", "given": "G\u00e1bor", "initials": "G"}, {"family": "Fuchsj\u00e4ger", "given": "Michael H", "initials": "MH"}, {"family": "Helbich", "given": "Thomas H", "initials": "TH"}, {"family": "Kilburn-Toppin", "given": "Fleur", "initials": "F"}, {"family": "Kuhl", "given": "Christiane K", "initials": "CK"}, {"family": "Lesaru", "given": "Mihai", "initials": "M"}, {"family": "Mann", "given": "Ritse M", "initials": "RM"}, {"family": "Panizza", "given": "Pietro", "initials": "P"}, {"family": "Pediconi", "given": "Federica", "initials": "F"}, {"family": "Pijnappel", "given": "Ruud M", "initials": "RM"}, {"family": "Sella", "given": "Tamar", "initials": "T"}, {"family": "Thomassin-Naggara", "given": "Isabelle", "initials": "I"}, {"family": "Zackrisson", "given": "Sophia", "initials": "S"}, {"family": "Gilbert", "given": "Fiona J", "initials": "FJ"}, {"family": "Sardanelli", "given": "Francesco", "initials": "F", "orcid": "0000-0001-6545-9427", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6ef97ff0f9b4b9b8b0c4396276bebe3.json"}}], "type": "journal article", "published": "2021-08-20", "journal": {"title": "Insights Imaging", "issn": "1869-4101", "volume": "12", "issue": "1", "pages": "119", "issn-l": null}, "abstract": "Unilateral axillary lymphadenopathy is a frequent mild side effect of COVID-19 vaccination. European Society of Breast Imaging (EUSOBI) proposes ten recommendations to standardise its management and reduce unnecessary additional imaging and invasive procedures: (1) in patients with previous history of breast cancer, vaccination should be performed in the contralateral arm or in the thigh; (2) collect vaccination data for all patients referred to breast imaging services, including patients undergoing breast cancer staging and follow-up imaging examinations; (3) perform breast imaging examinations preferentially before vaccination or at least 12 weeks after the last vaccine dose; (4) in patients with newly diagnosed breast cancer, apply standard imaging protocols regardless of vaccination status; (5) in any case of symptomatic or imaging-detected axillary lymphadenopathy before vaccination or at least 12 weeks after, examine with appropriate imaging the contralateral axilla and both breasts to exclude malignancy; (6) in case of axillary lymphadenopathy contralateral to the vaccination side, perform standard work-up; (7) in patients without breast cancer history and no suspicious breast imaging findings, lymphadenopathy only ipsilateral to the vaccination side within 12 weeks after vaccination can be considered benign or probably-benign, depending on clinical context; (8) in patients without breast cancer history, post-vaccination lymphadenopathy coupled with suspicious breast finding requires standard work-up, including biopsy when appropriate; (9) in patients with breast cancer history, interpret and manage post-vaccination lymphadenopathy considering the timeframe from vaccination and overall nodal metastatic risk; (10) complex or unclear cases should be managed by the multidisciplinary team.", "doi": "10.1186/s13244-021-01062-x", "pmid": "34417642", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13244-021-01062-x"}, {"db": "pmc", "key": "PMC8378785"}], "notes": [], "created": 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"https://publications-covid19.scilifelab.se/researcher/22f57b7602714f59bfbcc96a936d77a8.json"}}, {"family": "Bonfanti", "given": "Paolo", "initials": "P", "orcid": "0000-0001-7289-8823", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52b16f4f4f5c4031a8435f6f17e791c7.json"}}, {"family": "Biondi", "given": "Andrea", "initials": "A"}, {"family": "Tubiana", "given": "Sarah", "initials": "S", "orcid": "0000-0002-6526-6403", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c1b73b9bbe34e7b8f2b4acb82f9f438.json"}}, {"family": "Burdet", "given": "Charles", "initials": "C"}, {"family": "Nussbaum", "given": "Robert", "initials": "R", "orcid": "0000-0003-3445-8880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aabd2609b3e040328310c013efa546b2.json"}}, {"family": "Kahn-Kirby", "given": "Amanda", "initials": "A", "orcid": "0000-0002-8878-0413", "researcher": {"href": 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"researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ee6f7f1803e47de83ccf6f89964bce0.json"}}, {"family": "Puel", "given": "Anne", "initials": "A", "orcid": "0000-0003-2603-0323", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2bdac14a1d14b8496ffd12dac6df3e5.json"}}, {"family": "Boisson-Dupuis", "given": "St\u00e9phanie", "initials": "S", "orcid": "0000-0002-7115-116X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92c785f151bb490aa85764eb62c0508e.json"}}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "B\u00e9ziat", "given": "Vivien", "initials": "V", "orcid": "0000-0002-4020-824X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ec4013e8c1f41d3b3590231e846cfc6.json"}}, {"family": "Lifton", "given": "Richard P", "initials": "RP"}, {"family": "Bastard", "given": "Paul", "initials": "P", "orcid": "0000-0002-5926-8437", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e3388c840d04a25824530a9bf999f01.json"}}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD", "orcid": "0000-0002-8335-0262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3f0c0bf3c294622a95b062a5db4386d.json"}}, {"family": "Abel", "given": "Laurent", "initials": "L", "orcid": "0000-0001-7016-6493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fd6c4593c8c492a8dad8e49cb7a832a.json"}}, {"family": "Su", "given": "Helen C", "initials": "HC", "orcid": "0000-0002-5582-9110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad550813f03540d9a8240a3d96ad0829.json"}}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E", "orcid": "0000-0002-7358-9157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c50d261245743539a5813daffcaab72.json"}}, {"family": "Amara", "given": "Ali", "initials": "A"}, {"family": "Soumelis", "given": "Vassili", "initials": "V", "orcid": "0000-0003-1849-9834", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f213b2e1c984894b695760448e0f35b.json"}}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5369fe152ac94b5a81d4f913d85940a7.json"}}, {"family": "Zhang", "given": "Qian", "initials": "Q", "orcid": "0000-0002-9040-3289", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/341c0cb0fa7d41448e55344c82d68358.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL", "orcid": "0000-0002-7782-4169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1aca66ab7c39465faf2de03fa8a6722f.json"}}], "type": "journal article", "published": "2021-08-19", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "volume": "6", "issue": "62", "pages": "eabl4348", "issn-l": "2470-9468"}, "abstract": "Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare, biochemically deleterious X-linked TLR7 variants in 16 unrelated male individuals aged 7 to 71 years (mean: 36.7 years) from a cohort of 1,202 male patients aged 0.5 to 99 years (mean: 52.9 years) with unexplained critical COVID-19 pneumonia. None of the 331 asymptomatically or mildly infected male individuals aged 1.3 to 102 years (mean: 38.7 years) tested carry such TLR7 variants (p = 3.5 \u00d7 10-5). The phenotypes of five hemizygous relatives of index cases infected with SARS-CoV-2 include asymptomatic or mild infection (n=2, 5 and 38 years), or moderate (n=1, 5 years), severe (n=1, 27 years), or critical (n=1, 29 years) pneumonia. Two boys (aged 7 and 12 years) from a cohort of 262 male patients with severe COVID-19 pneumonia (mean: 51.0 years) are hemizygous for a deleterious TLR7 variant. The cumulative allele frequency for deleterious TLR7 variants in the male general population is < 6.5x10-4 We also show that blood B cell lines and myeloid cell subsets from the patients do not respond to TLR7 stimulation, a phenotype rescued by wild-type TLR7 The patients' blood plasmacytoid dendritic cells (pDCs) produce low levels of type I IFNs in response to SARS-CoV-2. Overall, X-linked recessive TLR7 deficiency is a highly penetrant genetic etiology of critical COVID-19 pneumonia, in about 1.8% of male patients below the age of 60 years. Human TLR7 and pDCs are essential for protective type I IFN immunity against SARS-CoV-2 in the respiratory tract.", "doi": "10.1126/sciimmunol.abl4348", "pmid": "34413140", "labels": {"Category: Proteins": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "mid", "key": "NIHMS1744435"}, {"db": "pmc", "key": "PMC8532080"}, {"db": "pii", "key": "6/62/eabl4348"}], "notes": [], "created": "2021-08-20T12:26:45.378Z", "modified": "2023-06-19T15:35:54.456Z"}, {"entity": "publication", "iuid": "7e0426156b054faf9b603d4ccb53cf7f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e0426156b054faf9b603d4ccb53cf7f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e0426156b054faf9b603d4ccb53cf7f"}}, "title": "Children's Expressions of Worry During the COVID-19 Pandemic in Sweden.", "authors": [{"family": "Sarkadi", "given": "Anna", "initials": "A"}, {"family": "Sahlin Torp", "given": "Lisa", "initials": "L"}, {"family": "P\u00e9rez-Aronsson", "given": "Anna", "initials": "A"}, {"family": "Warner", "given": "Georgina", "initials": "G", "orcid": "0000-0002-7850-9136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a44058151a6c4ff4be148921ad1e9e57.json"}}], "type": "journal article", "published": "2021-08-19", "journal": {"title": "J Pediatr Psychol", "issn": "1465-735X", "volume": "46", "issue": "8", "pages": "939-949", "issn-l": null}, "abstract": "Sweden is an international exception in its public health response to the COVID-19 pandemic, with a higher number of deaths, albeit not pediatric, compared with other Nordic countries. The objective of this study was to investigate what worries children and adolescents living in Sweden expressed in relation to the pandemic.\n\nUsing an anonymous web-survey, 1,047 children (4-12 years; N = 717) and adolescents (13-18 years; N = 330) responded to five background and four open-ended questions, one of which was: Is there anything that you are worried about when it comes to 'Corona'? The responses were coded using manifest content analysis. Interrater reliability was .95, assessed on the code level.\n\nWorry was common (77%); mostly (60%) related to disease or death of elderly relatives, parents, the child him/herself or general worry for the elderly/risk groups. Existential worry (15%) comprised worries about the future, including economy and worries about the world perishing or the contagion becoming uncontrollable. A developmental trajectory was evident in the nature of responses. Adolescents' worries about the future included missing out on their youth and employment. They also worried about society (6%), for example, the future of democracy and the world economy. There was no indication of socioeconomic status or geographic area (urban vs. rural) affecting the presence of worrisome thoughts.\n\nWorry about \"Corona\" was common. Universal preventative mental health intervention is warranted and could be conducted in the school setting. Intervention could be tailored by age, covering discussion on financial aspects with adolescents.", "doi": "10.1093/jpepsy/jsab060", "pmid": "34383921", "labels": {"Category: Public Health": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8376257"}, {"db": "pii", "key": "6349212"}], "notes": [], "created": "2023-01-13T13:42:08.183Z", "modified": "2023-01-13T13:42:08.229Z"}, {"entity": "publication", "iuid": "4a0182dcbd774f28879aa1e57743de3a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4a0182dcbd774f28879aa1e57743de3a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4a0182dcbd774f28879aa1e57743de3a"}}, "title": "Changes in Adolescents' Psychosocial Functioning and Well-Being as a Consequence of Long-Term COVID-19 Restrictions.", "authors": [{"family": "Kerekes", "given": "N\u00f3ra", "initials": "N", "orcid": "0000-0002-8854-0399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/175ef55a6f3b45909a0a76b55cc0e4b3.json"}}, {"family": "Bador", "given": "Kourosh", "initials": "K"}, {"family": "Sfendla", "given": "Anis", "initials": "A", "orcid": "0000-0001-7139-7058", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6f24957ee1054495b1e970210d5e1fb1.json"}}, {"family": "Belaatar", "given": "Mohjat", "initials": "M"}, {"family": "Mzadi", "given": "Abdennour El", "initials": "AE", "orcid": "0000-0002-0309-3586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d613682c3d36435c9bf4d0ec63d1c3fd.json"}}, {"family": "Jovic", "given": "Vladimir", "initials": "V"}, {"family": "Damjanovic", "given": "Rade", "initials": "R"}, {"family": "Erlandsson", "given": "Maria", "initials": "M"}, {"family": "Nguyen", "given": "Hang Thi Minh", "initials": "HTM"}, {"family": "Nguyen", "given": "Nguyet Thi Anh", "initials": "NTA"}, {"family": "Ulberg", "given": "Scott F", "initials": "SF"}, {"family": "Kuch-Cecconi", "given": "Rachael H", "initials": "RH"}, {"family": "Szombathyne Meszaros", "given": "Zsuzsa", "initials": "Z"}, {"family": "Stevanovic", "given": "Dejan", "initials": "D", "orcid": "0000-0001-8236-5246", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fd2d9e3b1114cf5bd2a89e5ab0dc766.json"}}, {"family": "Senhaji", "given": "Meftaha", "initials": "M"}, {"family": "Hedman Ahlstr\u00f6m", "given": "Britt", "initials": "B"}, {"family": "Zouini", "given": "Btissame", "initials": "B", "orcid": "0000-0002-9692-2397", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8935bc90d78143139467d7cfe522f70a.json"}}], "type": "journal article", "published": "2021-08-19", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "16", "pages": null}, "abstract": "This work studied self-reports from adolescents on how the COVID-19 pandemic has changed their behaviors, relationships, mood, and victimization. Data collection was conducted between September 2020 and February 2021 in five countries (Sweden, the USA, Serbia, Morocco, and Vietnam). In total, 5114 high school students (aged 15 to 19 years, 61.8% females) responded to our electronic survey. A substantial proportion of students reported decreased time being outside (41.7%), meeting friends in real life (59.4%), and school performance (30.7%), while reporting increased time to do things they did not have time for before (49.3%) and using social media to stay connected (44.9%). One third of the adolescents increased exercise and felt that they have more control over their life. Only a small proportion of adolescents reported substance use, norm-breaking behaviors, or victimization. The overall COVID-19 impact on adolescent life was gender-specific: we found a stronger negative impact on female students. The results indicated that the majority of adolescents could adapt to the dramatic changes in their environment. However, healthcare institutions, municipalities, schools, and social services could benefit from the findings of this study in their work to meet the needs of those young people who signaled worsened psychosocial functioning, increased stress, and victimization.", "doi": "10.3390/ijerph18168755", "pmid": "34444502", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph18168755"}, {"db": "pmc", "key": "PMC8392883"}], "notes": [], "created": "2021-09-01T07:27:23.293Z", "modified": "2021-11-18T13:38:07.614Z"}, {"entity": "publication", "iuid": "1f6e2f184718454591ec16406ead3ed1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1f6e2f184718454591ec16406ead3ed1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1f6e2f184718454591ec16406ead3ed1"}}, "title": "Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.", "authors": [{"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Gervais", "given": "Adrian", "initials": "A"}, {"family": "Le Voyer", "given": "Tom", "initials": "T"}, {"family": "Rosain", "given": "J\u00e9r\u00e9mie", "initials": "J"}, {"family": "Philippot", "given": "Quentin", "initials": "Q"}, {"family": "Manry", "given": "J\u00e9r\u00e9my", "initials": "J"}, {"family": "Michailidis", "given": "Eleftherios", "initials": "E"}, {"family": "Hoffmann", "given": "Hans-Heinrich", "initials": "HH"}, {"family": "Eto", "given": "Shohei", "initials": "S"}, {"family": "Garcia-Prat", "given": "Marina", "initials": "M"}, {"family": "Bizien", "given": "Lucy", "initials": "L"}, {"family": "Parra-Mart\u00ednez", "given": "Alba", "initials": "A"}, {"family": "Yang", "given": "Rui", "initials": "R"}, {"family": "Haljasm\u00e4gi", "given": "Liis", "initials": "L"}, {"family": "Migaud", "given": "M\u00e9lanie", "initials": "M"}, {"family": "S\u00e4rekannu", "given": "Karita", "initials": "K"}, {"family": "Maslovskaja", "given": "Julia", "initials": "J"}, {"family": "de Prost", "given": "Nicolas", "initials": "N"}, {"family": "Tandjaoui-Lambiotte", "given": "Yacine", "initials": "Y"}, {"family": "Luyt", "given": "Charles-Edouard", "initials": "CE"}, {"family": "Amador-Borrero", "given": "Blanca", "initials": "B"}, {"family": "Gaudet", "given": "Alexandre", "initials": "A"}, {"family": "Poissy", "given": "Julien", "initials": "J"}, {"family": "Morel", "given": "Pascal", "initials": "P"}, {"family": "Richard", "given": "Pascale", "initials": "P"}, {"family": "Cognasse", "given": "Fabrice", "initials": "F"}, {"family": "Troya", "given": "Jesus", "initials": "J"}, {"family": "Trouillet-Assant", "given": "Sophie", "initials": "S"}, {"family": "Belot", "given": "Alexandre", "initials": "A"}, {"family": "Saker", "given": "Kahina", "initials": "K"}, {"family": "Gar\u00e7on", "given": "Pierre", "initials": "P"}, {"family": "Rivi\u00e8re", "given": "Jacques G", "initials": "JG"}, {"family": "Lagier", "given": "Jean-Christophe", "initials": "JC"}, {"family": "Gentile", "given": "St\u00e9phanie", "initials": "S"}, {"family": "Rosen", "given": "Lindsey B", "initials": "LB"}, {"family": "Shaw", "given": "Elana", "initials": "E"}, {"family": "Morio", "given": "Tomohiro", "initials": "T"}, {"family": "Tanaka", "given": "Junko", "initials": "J"}, {"family": "Dalmau", "given": "David", "initials": "D"}, {"family": "Tharaux", "given": "Pierre-Louis", "initials": "PL"}, {"family": "Sene", "given": "Damien", "initials": "D"}, {"family": "Stepanian", "given": "Alain", "initials": "A"}, {"family": "Megarbane", "given": "Bruno", "initials": "B"}, {"family": "Triantafyllia", "given": "Vasiliki", "initials": "V"}, {"family": "Fekkar", "given": "Arnaud", "initials": "A"}, {"family": "Heath", "given": "James R", "initials": "JR"}, {"family": "Franco", "given": "Jos\u00e9 Luis", "initials": "JL"}, {"family": "Anaya", 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{"family": "Arrestier", "given": "Romain", "initials": "R"}, {"family": "Boudhabhay", "given": "Idris", "initials": "I"}, {"family": "Baris-Feldman", "given": "Hagit", "initials": "H"}, {"family": "Hagin", "given": "David", "initials": "D"}, {"family": "Wauters", "given": "Joost", "initials": "J"}, {"family": "Meyts", "given": "Isabelle", "initials": "I"}, {"family": "Dyer", "given": "Adam H", "initials": "AH"}, {"family": "Kennelly", "given": "Sean P", "initials": "SP"}, {"family": "Bourke", "given": "Nollaig M", "initials": "NM"}, {"family": "Halwani", "given": "Rabih", "initials": "R"}, {"family": "Sharif-Askari", "given": "Narjes Saheb", "initials": "NS"}, {"family": "Dorgham", "given": "Karim", "initials": "K"}, {"family": "Sallette", "given": "J\u00e9rome", "initials": "J"}, {"family": "Sedkaoui", "given": "Souad Mehlal", "initials": "SM"}, {"family": "AlKhater", "given": "Suzan", "initials": "S"}, {"family": "Rigo-Bonnin", "given": "Ra\u00fal", "initials": "R"}, {"family": "Morandeira", "given": "Francisco", "initials": "F"}, {"family": "Roussel", "given": "Lucie", "initials": "L"}, {"family": "Vinh", "given": "Donald C", "initials": "DC"}, {"family": "Ostrowski", "given": "Sisse Rye", "initials": "SR"}, {"family": "Condino-Neto", "given": "Antonio", "initials": "A"}, {"family": "Prando", "given": "Carolina", "initials": "C"}, {"family": "Bonradenko", "given": "Anastasiia", "initials": "A"}, {"family": "Spaan", "given": "Andr\u00e1s N", "initials": "AN"}, {"family": "Gilardin", "given": "Laurent", "initials": "L"}, {"family": "Fellay", "given": "Jacques", "initials": "J"}, {"family": "Lyonnet", "given": "Stanislas", "initials": "S"}, {"family": "Bilguvar", "given": "Kaya", "initials": "K"}, {"family": "Lifton", "given": "Richard P", "initials": "RP"}, {"family": "Mane", "given": "Shrikant", "initials": "S"}, {"family": "HGID Lab", "given": "", "initials": ""}, {"family": "COVID Clinicians", "given": "", "initials": ""}, {"family": "COVID-STORM 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{"family": "3C-Dijon Study", "given": "", "initials": ""}, {"family": "Cerba Health-Care", "given": "", "initials": ""}, {"family": "Etablissement du Sang study group", "given": "", "initials": ""}, {"family": "Anderson", "given": "Mark S", "initials": "MS"}, {"family": "Boisson", "given": "Bertrand", "initials": "B"}, {"family": "B\u00e9ziat", "given": "Vivien", "initials": "V"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Vandreakos", "given": "Evangelos", "initials": "E"}, {"family": "Hermine", "given": "Olivier", "initials": "O"}, {"family": "Pujol", "given": "Aurora", "initials": "A"}, {"family": "Peterson", "given": "P\u00e4rt", "initials": "P"}, {"family": "Mogensen", "given": "Trine H", "initials": "TH"}, {"family": "Rowen", "given": "Lee", "initials": "L"}, {"family": "Mond", "given": "James", "initials": "J"}, {"family": "Debette", "given": "St\u00e9phanie", "initials": "S"}, {"family": "de Lamballerie", "given": "Xavier", "initials": "X"}, {"family": "Duval", "given": "Xavier", "initials": "X"}, {"family": "Mentr\u00e9", "given": "France", "initials": "F"}, {"family": "Zins", "given": "Marie", "initials": "M"}, {"family": "Soler-Palacin", "given": "Pere", "initials": "P"}, {"family": "Colobran", "given": "Roger", "initials": "R"}, {"family": "Gorochov", "given": "Guy", "initials": "G"}, {"family": "Solanich", "given": "Xavier", "initials": "X"}, {"family": "Susen", "given": "Sophie", "initials": "S"}, {"family": "Martinez-Picado", "given": "Javier", "initials": "J"}, {"family": "Raoult", "given": "Didier", "initials": "D"}, {"family": "Vasse", "given": "Marc", "initials": "M"}, {"family": "Gregersen", "given": "Peter K", "initials": "PK"}, {"family": "Piemonti", "given": "Lorenzo", "initials": "L"}, {"family": "Rodr\u00edguez-Gallego", "given": "Carlos", "initials": "C"}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD"}, {"family": "Su", "given": "Helen C", "initials": "HC"}, {"family": "Kisand", "given": "Kai", "initials": "K"}, {"family": "Okada", "given": "Satoshi", "initials": "S"}, {"family": "Puel", "given": "Anne", "initials": "A"}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E"}, {"family": "Rice", "given": "Charles M", "initials": "CM"}, {"family": "Tiberghien", "given": "Pierre", "initials": "P"}, {"family": "Zhang", "given": "Qian", "initials": "Q"}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A"}, {"family": "Abel", "given": "Laurent", "initials": "L"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL"}], "type": "journal article", "published": "2021-08-19", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "issn-l": "2470-9468", "volume": "6", "issue": "62", "pages": "eabl4340"}, "abstract": "Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-\u03b1 and/or -\u03c9 are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-\u03b1 and/or -\u03c9 (100 pg/mL, in 1/10 dilutions of plasma) in 13.6% of 3,595 patients with critical COVID-19, including 21% of 374 patients > 80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1,124 deceased patients (aged 20 days-99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-\u03b2. We also show, in a sample of 34,159 uninfected subjects from the general population, that auto-Abs neutralizing high concentrations of IFN-\u03b1 and/or -\u03c9 are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of subjects carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-\u03b2 do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over-80s, and total fatal COVID-19 cases.", "doi": "10.1126/sciimmunol.abl4340", "pmid": "34413139", "labels": {"Category: Proteins": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "mid", "key": "NIHMS1744468"}, {"db": "pmc", "key": "PMC8521484"}, {"db": "pii", "key": "6/62/eabl4340"}], "notes": [], "created": "2021-08-20T06:48:41.370Z", "modified": "2023-06-19T15:35:29.233Z"}, {"entity": "publication", "iuid": "7a67796ea81f41569b69fcc5d74102d3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a67796ea81f41569b69fcc5d74102d3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a67796ea81f41569b69fcc5d74102d3"}}, "title": "Two cases of severe COVID-19 in gestational week 27 and 28 respectively, after which both pregnancies proceeded to term.", "authors": [{"family": "\u00d6stling", "given": "H", "initials": "H"}, {"family": "Ugarph-Edfeldt", "given": "M", "initials": "M"}, {"family": "Hild\u00e9n", "given": "K", "initials": "K"}], "type": "case reports", "published": "2021-08-18", "journal": {"title": "Int J Obstet Anesth", "issn": "1532-3374", "volume": "48", "pages": "103212", "issn-l": null}, "abstract": "COVID-19 in pregnancy increases the risk of caesarean section. We present two cases of late gestation pregnant women with severe COVID-19. Both were successfully treated with mechanical ventilation without termination of pregnancy and, following recovery from COVID-19, had vaginal deliveries at term. These two cases demonstrate the possibility of treating pregnant women with severe COVID-19 with mechanical ventilation in the late second and early third trimesters without them having a pre-term delivery. With a multidisciplinary approach, such management could avoid the maternal risks of surgery during a severe infection and, at the same time, enable term birth with a lower risk of neonatal complications.", "doi": "10.1016/j.ijoa.2021.103212", "pmid": "34500190", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0959-289X(21)00270-3"}, {"db": "pmc", "key": "PMC8372455"}], "notes": [], "created": "2021-09-13T06:07:55.917Z", "modified": "2021-09-13T06:07:55.944Z"}, {"entity": "publication", "iuid": "30a815cc31754725934d9486c0e487ac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/30a815cc31754725934d9486c0e487ac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/30a815cc31754725934d9486c0e487ac"}}, "title": "Fear of COVID-19 and religious coping mediate the associations between religiosity and distress among older adults.", "authors": [{"family": "Asgari Ghoncheh", "given": "Karim", "initials": "K", "orcid": "0000-0003-0127-9480", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac0b0c26ed9246f4b4f4f75c80fce4da.json"}}, {"family": "Liu", "given": "Chieh-Hsiu", "initials": "CH"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Saffari", "given": "Mohsen", "initials": "M"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-08-18", "journal": {"title": "Health Promot Perspect", "issn": "2228-6497", "volume": "11", "issue": "3", "pages": "316-322", "issn-l": null}, "abstract": "Background: A mediation model was proposed to explain how religiosity, religious coping, and fear of coronavirus disease 2019 (COVID-19) explained anxiety and depression among older adults. Methods: With the use of a cross-sectional design, the Integrated Health System was used to randomly invite 1000 older adults residing in Qazvin to participate in an online survey. Within the period of November 2020 to January 2021, 696 older Iranian adults (mean age=69.56years; 57.9% women) agreed to participate in the study and reported demographic information as well as measures of religiosity, fear of COVID-19, religious coping, anxiety, and depression. Results: Religiosity had direct effects on depression (B [SE]=-0.087 [0.037]; P=0.023) but not anxiety (B [SE]=-0.063 [0.036]; P=0.072). Moreover, both fear of COVID-19 and religious coping significantly mediated the association between religiosity and anxiety (B [SE]=-0.360[0.035]; p=0.002) and that between religiosity and depression (B [SE]=-0.365 [0.034];P=0.002). Conclusion: During the tough time of COVID-19 pandemic, religiosity and religious coping were protectors for older adults in developing good mental. Therefore, future research is needed to examine education programs that are effective for older adults to obtain correct knowledge concerning COVID-19, including the protective COVID-19 infection behaviors. Therefore, older adults may reduce their fear via their enhanced correct knowledge concerning COVID-19.", "doi": "10.34172/hpp.2021.40", "pmid": "34660226", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8501474"}], "notes": [], "created": "2021-10-21T05:00:52.748Z", "modified": "2021-10-21T05:00:52.832Z"}, {"entity": "publication", "iuid": "7d7f3577978a4f85a174146b372fc4a5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d7f3577978a4f85a174146b372fc4a5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d7f3577978a4f85a174146b372fc4a5"}}, "title": "Southeast Asia is an emerging hotspot for COVID-19.", "authors": [{"family": "Chookajorn", "given": "Thanat", "initials": "T", "orcid": "0000-0003-2876-6203", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d23832ce2a8a4f1aaa4420c4beb68da3.json"}}, {"family": "Kochakarn", "given": "Theerarat", "initials": "T", "orcid": "0000-0002-3524-8079", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89f005dd677d4a118a343d260dd8a3ef.json"}}, {"family": "Wilasang", "given": "Chaiwat", "initials": "C"}, {"family": "Kotanan", "given": "Namfon", "initials": "N"}, {"family": "Modchang", "given": "Charin", "initials": "C"}], "type": "letter", "published": "2021-08-16", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956"}, "abstract": null, "doi": "10.1038/s41591-021-01471-x", "pmid": "34400842", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-021-01471-x"}], "notes": [], "created": "2021-08-18T07:32:32.235Z", "modified": "2021-08-18T07:32:32.304Z"}, {"entity": "publication", "iuid": "1148627e160a4b4c83b7700fd26ae64d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1148627e160a4b4c83b7700fd26ae64d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1148627e160a4b4c83b7700fd26ae64d"}}, "title": "No difference in biomarkers of ischemic heart injury and heart failure in patients with COVID-19 who received treatment with chloroquine phosphate and those who did not.", "authors": [{"family": "Beck-Friis", "given": "Josefine", "initials": "J", "orcid": "0000-0003-2400-4092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3f3764c8d95410abc83f9c3cca2eaeb.json"}}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Omerovic", "given": "Elmir", "initials": "E"}, {"family": "Zeijlon", "given": "Rickard", "initials": "R", "orcid": "0000-0001-6422-604X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ad7b579fe034ce0b8baf9c7b9209c4f.json"}}, {"family": "Gisslen", "given": "Magnus", "initials": "M"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}], "type": "journal article", "published": "2021-08-16", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "8", "pages": "e0256035"}, "abstract": "Chloroquine was promoted as a COVID-19 therapeutic early in the pandemic. Most countries have since discontinued the use of chloroquine due to lack of evidence of any benefit and the risk of severe adverse events. The primary aim of this study was to examine if administering chloroquine during COVID-19 imposed an increased risk of ischemic heart injury or heart failure.\n\nMedical records, laboratory findings, and electrocardiograms of patients with COVID-19 who were treated with 500 mg chloroquine phosphate daily and controls not treated with chloroquine were reviewed retrospectively. Controls were matched in age and severity of disease.\n\nWe included 20 patients receiving chloroquine (500 mg twice daily) for an average of five days, and 40 controls. The groups were comparable regarding demographics and biochemical analyses including C-reactive protein, thrombocytes, and creatinine. There were no statistically significant differences in cardiac biomarkers or in electrocardiograms. Median troponin T was 10,8 ng/L in the study group and 17.9 ng/L in the control group, whereas median NT-proBNP was 399 ng/L in patients receiving chloroquine and 349 ng/L in the controls.\n\nWe found no increased risk of ischemic heart injury or heart failure as a result of administering chloroquine. However, the use of chloroquine to treat COVID-19 outside of clinical trials is not recommended, considering the lack of evidence of its effectiveness, as well as the elevated risk of fatal arrythmias.", "doi": "10.1371/journal.pone.0256035", "pmid": "34398893", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8366976"}, {"db": "pii", "key": "PONE-D-21-05531"}], "notes": [], "created": "2021-08-17T06:33:30.817Z", "modified": "2023-06-19T14:22:31.683Z"}, {"entity": "publication", "iuid": "f4d2a4bb9cc542238ce4a63f1852e405", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f4d2a4bb9cc542238ce4a63f1852e405.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f4d2a4bb9cc542238ce4a63f1852e405"}}, "title": "The New Generation hDHODH Inhibitor MEDS433 Hinders the In Vitro Replication of SARS-CoV-2 and Other Human Coronaviruses.", "authors": [{"family": "Calistri", "given": "Arianna", "initials": "A", "orcid": "0000-0002-6881-7936", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbe9daeedf2e470da0d6dc15c0ad0b42.json"}}, {"family": "Luganini", "given": "Anna", "initials": "A", "orcid": "0000-0003-4256-5774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d50b50e8ca94f6cae15ba017327c531.json"}}, {"family": "Mognetti", "given": "Barbara", "initials": "B", "orcid": "0000-0003-2888-8999", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d3c5265b63e4d5b876a49be6ff1fdcb.json"}}, {"family": "Elder", "given": "Elizabeth", "initials": "E"}, {"family": "Sibille", "given": "Giulia", "initials": "G", "orcid": "0000-0002-2869-357X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c182e329cc844e8a77cc79d9aa3066b.json"}}, {"family": "Conciatori", "given": "Valeria", "initials": "V"}, {"family": "Del Vecchio", "given": "Claudia", "initials": "C"}, {"family": "Sainas", "given": "Stefano", "initials": "S", "orcid": "0000-0001-5010-8536", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76b9175a3f6948ce805df8750a31af27.json"}}, {"family": "Boschi", "given": "Donatella", "initials": "D", "orcid": "0000-0003-4929-4460", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/553f31793fda4fffb7b98c6ffe323957.json"}}, {"family": "Montserrat", "given": "Nuria", "initials": "N"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Lolli", "given": "Marco Lucio", "initials": "ML"}, {"family": "Gribaudo", "given": "Giorgio", "initials": "G", "orcid": "0000-0002-1583-9146", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b1ea434d6b04d26a764cde7dd4ff21b.json"}}, {"family": "Parolin", "given": "Cristina", "initials": "C"}], "type": "journal article", "published": "2021-08-14", "journal": {"title": "Microorganisms", "issn": "2076-2607", "issn-l": "2076-2607", "volume": "9", "issue": "8", "pages": "1731"}, "abstract": "Although coronaviruses (CoVs) have long been predicted to cause zoonotic diseases and pandemics with high probability, the lack of effective anti-pan-CoVs drugs rapidly usable against the emerging SARS-CoV-2 actually prevented a promptly therapeutic intervention for COVID-19. Development of host-targeting antivirals could be an alternative strategy for the control of emerging CoVs infections, as they could be quickly repositioned from one pandemic event to another. To contribute to these pandemic preparedness efforts, here we report on the broad-spectrum CoVs antiviral activity of MEDS433, a new inhibitor of the human dihydroorotate dehydrogenase (hDHODH), a key cellular enzyme of the de novo pyrimidine biosynthesis pathway. MEDS433 inhibited the in vitro replication of hCoV-OC43 and hCoV-229E, as well as of SARS-CoV-2, at low nanomolar range. Notably, the anti-SARS-CoV-2 activity of MEDS433 against SARS-CoV-2 was also observed in kidney organoids generated from human embryonic stem cells. Then, the antiviral activity of MEDS433 was reversed by the addition of exogenous uridine or the product of hDHODH, the orotate, thus confirming hDHODH as the specific target of MEDS433 in hCoVs-infected cells. Taken together, these findings suggest MEDS433 as a potential candidate to develop novel drugs for COVID-19, as well as broad-spectrum antiviral agents exploitable for future CoVs threats.", "doi": "10.3390/microorganisms9081731", "pmid": "34442810", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8398173"}, {"db": "pii", "key": "microorganisms9081731"}], "notes": [], "created": "2021-09-01T07:26:00.780Z", "modified": "2023-06-19T14:33:43.533Z"}, {"entity": "publication", "iuid": "1b3ba7feed27435d99d45ec43fa13eb4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b3ba7feed27435d99d45ec43fa13eb4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b3ba7feed27435d99d45ec43fa13eb4"}}, "title": "Risk of acute myocardial infarction and ischaemic stroke following COVID-19 in Sweden: a self-controlled case series and matched cohort study.", "authors": [{"family": "Katsoularis", "given": "Ioannis", "initials": "I"}, {"family": "Fonseca-Rodr\u00edguez", "given": "Osvaldo", "initials": "O"}, {"family": "Farrington", "given": "Paddy", "initials": "P"}, {"family": "Lindmark", "given": "Krister", "initials": "K"}, {"family": "Fors Connolly", "given": "Anne-Marie", "initials": "AM"}], "type": "journal article", "published": "2021-08-14", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "398", "issue": "10300", "pages": "599-607", "issn-l": "0140-6736"}, "abstract": "COVID-19 is a complex disease targeting many organs. Previous studies highlight COVID-19 as a probable risk factor for acute cardiovascular complications. We aimed to quantify the risk of acute myocardial infarction and ischaemic stroke associated with COVID-19 by analysing all COVID-19 cases in Sweden.\n\nThis self-controlled case series (SCCS) and matched cohort study was done in Sweden. The personal identification numbers of all patients with COVID-19 in Sweden from Feb 1 to Sept 14, 2020, were identified and cross-linked with national inpatient, outpatient, cancer, and cause of death registers. The controls were matched on age, sex, and county of residence in Sweden. International Classification of Diseases codes for acute myocardial infarction or ischaemic stroke were identified in causes of hospital admission for all patients with COVID-19 in the SCCS and all patients with COVID-19 and the matched control individuals in the matched cohort study. The SCCS method was used to calculate the incidence rate ratio (IRR) for first acute myocardial infarction or ischaemic stroke following COVID-19 compared with a control period. The matched cohort study was used to determine the increased risk that COVID-19 confers compared with the background population of increased acute myocardial infarction or ischaemic stroke in the first 2 weeks following COVID-19.\n\n86 742 patients with COVID-19 were included in the SCCS study, and 348 481 matched control individuals were also included in the matched cohort study. When day of exposure was excluded from the risk period in the SCCS, the IRR for acute myocardial infarction was 2\u00b789 (95% CI 1\u00b751-5\u00b755) for the first week, 2\u00b753 (1\u00b729-4\u00b794) for the second week, and 1\u00b760 (0\u00b784-3\u00b704) in weeks 3 and 4 following COVID-19. When day of exposure was included in the risk period, IRR was 8\u00b744 (5\u00b745-13\u00b708) for the first week, 2\u00b756 (1\u00b731-5\u00b701) for the second week, and 1\u00b762 (0\u00b785-3\u00b709) for weeks 3 and 4 following COVID-19. The corresponding IRRs for ischaemic stroke when day of exposure was excluded from the risk period were 2\u00b797 (1\u00b771-5\u00b715) in the first week, 2\u00b780 (1\u00b760-4\u00b788) in the second week, and 2\u00b710 (1\u00b733-3\u00b732) in weeks 3 and 4 following COVID-19; when day of exposure was included in the risk period, the IRRs were 6\u00b718 (4\u00b706-9\u00b742) for the first week, 2\u00b785 (1\u00b764-4\u00b797) for the second week, and 2\u00b714 (1\u00b736-3\u00b738) for weeks 3 and 4 following COVID-19. In the matched cohort analysis excluding day 0, the odds ratio (OR) for acute myocardial infarction was 3\u00b741 (1\u00b758-7\u00b736) and for stroke was 3\u00b763 (1\u00b769-7\u00b780) in the 2 weeks following COVID-19. When day 0 was included in the matched cohort study, the OR for acute myocardial infarction was 6\u00b761 (3\u00b756-12\u00b720) and for ischaemic stroke was 6\u00b774 (3\u00b771-12\u00b720) in the 2 weeks following COVID-19.\n\nOur findings suggest that COVID-19 is a risk factor for acute myocardial infarction and ischaemic stroke. This indicates that acute myocardial infarction and ischaemic stroke represent a part of the clinical picture of COVID-19, and highlights the need for vaccination against COVID-19.\n\nCentral ALF-funding and Base Unit ALF-Funding, Region V\u00e4sterbotten, Sweden; Strategic funding during 2020 from the Department of Clinical Microbiology, Ume\u00e5 University, Sweden; Stroke Research in Northern Sweden; The Laboratory for Molecular Infection Medicine Sweden.", "doi": "10.1016/S0140-6736(21)00896-5", "pmid": "34332652", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8321431"}, {"db": "pii", "key": "S0140-6736(21)00896-5"}], "notes": [], "created": "2021-08-04T17:01:26.792Z", "modified": "2023-07-13T11:26:15.336Z"}, {"entity": "publication", "iuid": "76ce0eac73b046a3b39f4ca61d43e623", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76ce0eac73b046a3b39f4ca61d43e623.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76ce0eac73b046a3b39f4ca61d43e623"}}, "title": "The impact of first and second wave of COVID-19 on knee and hip surgeries in Sweden.", "authors": [{"family": "Dell'Isola", "given": "Andrea", "initials": "A", "orcid": "0000-0002-0319-458X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d8ea417b7c447f8bc4da9f47f9feb39.json"}}, {"family": "Kiadaliri", "given": "Ali", "initials": "A"}, {"family": "Turkiewicz", "given": "Aleksandra", "initials": "A"}, {"family": "Hughes", "given": "Velocity", "initials": "V"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}, {"family": "Runhaar", "given": "Jos", "initials": "J"}, {"family": "Bierma-Zeinstra", "given": "Sita", "initials": "S"}, {"family": "Englund", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2021-08-13", "journal": {"title": "J Exp Orthop", "issn": "2197-1153", "volume": "8", "issue": "1", "pages": "60", "issn-l": null}, "abstract": "To investigate the impact of COVID-19 in Sweden on rates of knee and hip surgeries.\n\nWe used healthcare data for the population of the southernmost region in Sweden (1.4 million inhabitants). We did an interrupted time-series analysis to estimate changes in rates and trends of joint replacements (JR), arthroscopies, and fracture surgeries for knee or hip in April-December 2020 compared to pre-COVID-19 levels adjusting for seasonal variations.\n\nWe found a drop of 54% (95% CI 42%; 68%) and 42% (95% CI 32%; 52%), respectively, in the rate of JRs and arthroscopies in April 2020 when compared to the counterfactual scenario. This was followed by an increase that brought the rates of JRs and arthroscopies back to their predicted levels also during the beginning of the second wave (November-December 2020). Acute fracture surgeries were largely unaffected, i.e. did not show any decrease as observed for the other surgeries.\n\nIn southern Sweden, we observed a marked decrease in elective knee and hip surgeries following the first wave of Covid-19. The rates remained close to normal during the beginning of the second wave suggesting that important elective surgeries for patients with end-stage osteoarthritis can still be offered despite an ongoing pandemic provided adequate routines and hospital resources.", "doi": "10.1186/s40634-021-00382-7", "pmid": "34389919", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s40634-021-00382-7"}], "notes": [], "created": "2021-08-16T09:31:35.898Z", "modified": "2021-08-16T09:31:35.951Z"}, {"entity": "publication", "iuid": "1093e74c258e4557b0c0b7cf5b9a8ebf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1093e74c258e4557b0c0b7cf5b9a8ebf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1093e74c258e4557b0c0b7cf5b9a8ebf"}}, "title": "Patterns of prescription dispensation and over-the-counter medication sales in Sweden during the COVID-19 pandemic.", "authors": [{"family": "Karlsson", "given": "P\u00e4r", "initials": "P"}, {"family": "Nakitanda", "given": "Aya Olivia", "initials": "AO"}, {"family": "L\u00f6fling", "given": "Lukas", "initials": "L", "orcid": "0000-0002-2731-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/791065e777f04244b251fb5a167cf33f.json"}}, {"family": "Cesta", "given": "Carolyn E", "initials": "CE", "orcid": "0000-0001-5759-9366", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd628fbbf6614769a1d8ad40b78b8093.json"}}], "type": "journal article", "published": "2021-08-13", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "8", "pages": "e0253944", "issn-l": "1932-6203"}, "abstract": "On February 26th 2020, a high alert was issued in Sweden in response to the diagnosis of the first few coronavirus disease 2019 (COVID-19) cases in the country. Subsequently, a decreased supply of essential goods, including medical products, was anticipated. We aimed to explore the weekly patterns of prescription dispensing and over-the-counter (OTC) medication sales in Sweden in 2020 compared with previous years, to assess the influence of the government restrictions on medication sales, and to assess whether there is evidence of medication stockpiling in the population.\n\nAggregated data on the weekly volume of defined daily doses (DDDs) of prescription medication dispensed and OTC sales from 2015 to 2020 were examined. From 2015-2019 data, the predicted weekly volume of DDDs for 2020 was estimated and compared to the observed volume for each ATC anatomical main group and therapeutic subgroup.\n\nFrom mid-February to mid-March 2020, there were increases in the weekly volumes of dispensed medication, peaking in the second week of March with a 46% increase in the observed versus predicted number of DDDs dispensed (16,440 vs 11,260 DDDs per 1000 inhabitants). A similar pattern was found in all age groups, in both sexes, and across metropolitan and non-metropolitan regions. In the same week in March, there was a 96% increase in the volume of OTC sold (2,504 vs 1,277 DDDs per 1000 inhabitants), specifically in ATC therapeutic subgroups including vitamins, antipyretics, painkillers, and nasal, throat, cough and cold preparations.\n\nBeginning in mid-February 2020, there were significant changes in the volume of prescription medication dispensed and OTC drugs sold. The weekly volume of DDDs quickly decreased following recommendations from public authorities. Overall, our findings suggest stockpiling behavior over a surge in new users of medication.", "doi": "10.1371/journal.pone.0253944", "pmid": "34388166", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-06619"}], "notes": [], "created": "2021-08-16T09:23:40.853Z", "modified": "2021-08-16T09:23:40.907Z"}, {"entity": "publication", "iuid": "762adfb81a5b46adadce0d32a76d9bfd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/762adfb81a5b46adadce0d32a76d9bfd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/762adfb81a5b46adadce0d32a76d9bfd"}}, "title": "Genetic-based adaptive momentum estimation for predicting mortality risk factors for COVID-19 patients using deep learning.", "authors": [{"family": "Elghamrawy", "given": "Sally M", "initials": "SM", "orcid": "0000-0002-5430-390X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ed6eb2f2b245401b8ad977256a3e918d.json"}}, {"family": "Hassanien", "given": "Aboul Ella", "initials": "AE", "orcid": "0000-0002-9989-6681", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28d8d8edeb454ee78721318261a3f18c.json"}}, {"family": "Vasilakos", "given": "Athanasios V", "initials": "AV", "orcid": "0000-0003-1902-9877", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3315b301bfc45188d847998d929de44.json"}}], "type": "journal article", "published": "2021-08-13", "journal": {"title": "Int J Imaging Syst Technol", "issn": "0899-9457", "issn-l": null}, "abstract": "The mortality risk factors for coronavirus disease (COVID-19) must be early predicted, especially for severe cases, to provide intensive care before they develop to critically ill immediately. This paper aims to develop an optimized convolution neural network (CNN) for predicting mortality risk factors for COVID-19 patients. The proposed model supports two types of input data clinical variables and the computed tomography (CT) scans. The features are extracted from the optimized CNN phase and then applied to the classification phase. The CNN model's hyperparameters were optimized using a proposed genetic-based adaptive momentum estimation (GB-ADAM) algorithm. The GB-ADAM algorithm employs the genetic algorithm (GA) to optimize Adam optimizer's configuration parameters, consequently improving the classification accuracy. The model is validated using three recent cohorts from New York, Mexico, and Wuhan, consisting of 3055, 7497,504 patients, respectively. The results indicated that the most significant mortality risk factors are: CD T Lymphocyte (Count), D-dimer greater than 1 Ug/ml, high values of lactate dehydrogenase (LDH), C-reactive protein (CRP), hypertension, and diabetes. Early identification of these factors would help the clinicians in providing immediate care. The results also show that the most frequent COVID-19 signs in CT scans included ground-glass opacity (GGO), followed by crazy-paving pattern, consolidations, and the number of lobes. Moreover, the experimental results show encouraging performance for the proposed model compared with different predicting models. 8 +", "doi": "10.1002/ima.22644", "pmid": "34518740", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "IMA22644"}, {"db": "pmc", "key": "PMC8426801"}], "notes": [], "created": "2021-09-20T06:28:02.045Z", "modified": "2021-09-20T06:28:17.272Z"}, {"entity": "publication", "iuid": "c3f75996c34f458d839411152ca3bb3f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3f75996c34f458d839411152ca3bb3f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3f75996c34f458d839411152ca3bb3f"}}, "title": "COVID-19 vaccine uptake among older people in relation to sociodemographic factors \u2013cohort results from southern Sweden", "authors": [{"family": "Inghammar", "given": "Malin", "initials": "M", "orcid": "0000-0003-2995-1312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4ab710428614cccb2a537ecab31d0a0.json"}}, {"family": "Moghaddassi", "given": "Mahnaz", "initials": "M", "orcid": "0000-0002-0844-4736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a219bde5ba8a4f3f8655ada08d749885.json"}}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}, {"family": "Malmqvist", "given": "Ulf", "initials": "U"}, {"family": "Kahn", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-5566-6350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42eda71f3775400599febc10a4e7359c.json"}}, {"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J", "orcid": "0000-0003-1883-2000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e88fdca336ae41c891f0a46e2481b67f.json"}}], "type": "posted-content", "published": "2021-08-13", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.08.12.21261981", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-08-16T11:25:49.928Z", "modified": "2021-11-29T06:15:40.860Z"}, {"entity": "publication", "iuid": "097f0660da62413b87a2a1e5b5db78de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/097f0660da62413b87a2a1e5b5db78de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/097f0660da62413b87a2a1e5b5db78de"}}, "title": "Applications of Artificial Intelligence, Machine Learning, Big Data and the Internet of Things to the COVID-19 Pandemic: A Scientometric Review Using Text Mining.", "authors": [{"family": "Rodr\u00edguez-Rodr\u00edguez", "given": "Ignacio", "initials": "I", "orcid": "0000-0002-0118-3406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7dade1cd1ba4f55b4851886236a8f2f.json"}}, {"family": "Rodr\u00edguez", "given": "Jos\u00e9-V\u00edctor", "initials": "JV", "orcid": "0000-0002-3298-6439", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1fa087057b0d4db88f835464f5236c24.json"}}, {"family": "Shirvanizadeh", "given": "Niloofar", "initials": "N"}, {"family": "Ortiz", "given": "Andr\u00e9s", "initials": "A", "orcid": "0000-0003-2690-1926", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49783f8986ae4250b181ee1a68c3df35.json"}}, {"family": "Pardo-Quiles", "given": "Domingo-Javier", "initials": "DJ", "orcid": "0000-0003-3240-2568", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/334b10db57e745928464250074151e78.json"}}], "type": "journal article", "published": "2021-08-13", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "16", "issn-l": null}, "abstract": "The COVID-19 pandemic has wreaked havoc in every country in the world, with serious health-related, economic, and social consequences. Since its outbreak in March 2020, many researchers from different fields have joined forces to provide a wide range of solutions, and the support for this work from artificial intelligence (AI) and other emerging concepts linked to intelligent data analysis has been decisive. The enormous amount of research and the high number of publications during this period makes it difficult to obtain an overall view of the different applications of AI to the management of COVID-19 and an understanding of how research in this field has been evolving. Therefore, in this paper, we carry out a scientometric analysis of this area supported by text mining, including a review of 18,955 publications related to AI and COVID-19 from the Scopus database from March 2020 to June 2021 inclusive. For this purpose, we used VOSviewer software, which was developed by researchers at Leiden University in the Netherlands. This allowed us to examine the exponential growth in research on this issue and its distribution by country, and to highlight the clear hegemony of the United States (USA) and China in this respect. We used an automatic process to extract topics of research interest and observed that the most important current lines of research focused on patient-based solutions. We also identified the most relevant journals in terms of the COVID-19 pandemic, demonstrated the growing value of open-access publication, and highlighted the most influential authors by means of an analysis of citations and co-citations. This study provides an overview of the current status of research on the application of AI to the pandemic.", "doi": "10.3390/ijerph18168578", "pmid": "34444327", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijerph18168578"}, {"db": "pmc", "key": "PMC8393243"}], "notes": [], "created": "2021-09-01T07:26:54.980Z", "modified": "2021-09-01T07:26:55.090Z"}, {"entity": "publication", "iuid": "c92743112e0b41f9b2e3e36932da3580", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c92743112e0b41f9b2e3e36932da3580.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c92743112e0b41f9b2e3e36932da3580"}}, "title": "Neutralization of VOCs including Delta one year post COVID-19 or vaccine", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Ng", "given": "Henry", "initials": "H"}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Lindbo", "given": "Sarah", "initials": "S"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "posted-content", "published": "2021-08-12", "journal": {"title": "MedRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.08.12.21261951", "pmid": null, "labels": {"Type: Preprint": null, "Research Area: Host cell systems biology and targets": null, "Research Area: Drug discovery and repurposing of drugs": null, "Category: Biochemistry": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Research Area: High-throughput and high-content serology": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-08-16T11:27:28.128Z", "modified": "2023-06-19T14:28:25.881Z"}, {"entity": "publication", "iuid": "39de810995674ece9f905bd11df5bd41", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/39de810995674ece9f905bd11df5bd41.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/39de810995674ece9f905bd11df5bd41"}}, "title": "Low mortality rates among critically-ill adults with COVID-19 at three non-academic intensive care units in south Sweden.", "authors": [{"family": "Taxbro", "given": "Knut", "initials": "K", "orcid": "0000-0001-8711-9044", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53d41b4a81184f4da24af4065e0371e1.json"}}, {"family": "Granath", "given": "Andreas", "initials": "A"}, {"family": "Sunnergren", "given": "Ola", "initials": "O"}, {"family": "Seifert", "given": "Stefanie", "initials": "S"}, {"family": "Jakubczyk", "given": "Milena N", "initials": "MN"}, {"family": "Persson", "given": "Magnus", "initials": "M"}, {"family": "Hammarskj\u00f6ld", "given": "Anneli", "initials": "A"}, {"family": "Alkemark", "given": "Catarina", "initials": "C"}, {"family": "Hammarskj\u00f6ld", "given": "Fredrik", "initials": "F"}, {"family": "RJL COVID-19 research group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-08-12", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172"}, "abstract": "The COVID-19 pandemic has put an exceptional strain on intensive care units worldwide. During the first year, the survival of patients with acute hypoxaemic respiratory failure appears to have improved. We aimed to describe the mortality rates, management characteristics, and two pandemic waves during the first year at three non-academic rural intensive care units in Sweden.\n\nWe retrospectively analysed all cases of COVID-19 admitted to intensive care units in Region J\u00f6nk\u00f6ping County during one year. The primary endpoint was 30-day mortality.\n\nBetween 14th March 2020 and 13th March 2021, two-hundred and sixty-four patients were admitted to undergo intensive care with confirmed SARS-CoV-2 infection. The 30-day mortality rate after the initial intensive care admission was 12.9%, and this rate remained unchanged during both pandemic waves. However, we found several distinct differences between the two pandemic waves, including an increase in the use of high-flow nasal oxygen but a decrease in invasive mechanical ventilation use, biochemical markers of inflammation, continuous renal replacement therapy, and length of stay in the intensive care unit.\n\nOur study showed that critically ill patients with COVID-19 in Sweden have a low 30-day mortality rate which compares well with results published from academic centres and national cohorts throughout Scandinavia. During the second pandemic wave, the proportion of patients receiving invasive mechanical ventilation and continuous renal replacement therapy was lower than that in the first wave. This could be the result of increased knowledge and improved therapeutic options.", "doi": "10.1111/aas.13972", "pmid": "34386972", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-16T09:24:31.418Z", "modified": "2021-08-16T09:24:31.457Z"}, {"entity": "publication", "iuid": "a6742f8afc5b48b3897d5ef91387d725", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6742f8afc5b48b3897d5ef91387d725.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6742f8afc5b48b3897d5ef91387d725"}}, "title": "Air pollution and COVID-19: clearing the air and charting a post-pandemic course: a joint workshop report of ERS, ISEE, HEI and WHO", "authors": [{"family": "Andersen", "given": "Zorana J", "initials": "ZJ"}, {"family": "Hoffmann", "given": "Barbara", "initials": "B"}, {"family": "Morawska", "given": "Lidia", "initials": "L"}, {"family": "Adams", "given": "Martin", "initials": "M"}, {"family": "Furman", "given": "Eeva", "initials": "E"}, {"family": "Yorgancioglu", "given": "Arzu", "initials": "A"}, {"family": "Greenbaum", "given": "Dan", "initials": "D"}, {"family": "Neira", "given": "Maria", "initials": "M"}, {"family": "Brunekreef", "given": "Bert", "initials": "B"}, {"family": "Forastiere", "given": "Francesco", "initials": "F"}, {"family": "Rice", "given": "Mary B", "initials": "MB", "orcid": "0000-0003-2538-391X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b3b44173ee84de8bde4fe34352e40c3.json"}}, {"family": "Wakenhut", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Coleen", "given": "Erika", "initials": "E"}, {"family": "Boogaard", "given": "Hanna", "initials": "H"}, {"family": "Gehring", "given": "Ulrike", "initials": "U"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E", "orcid": "0000-0002-8248-0663", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58e96082947e4752a23f322e42754097.json"}}, {"family": "Ward", "given": "Brian", "initials": "B"}, {"family": "De Matteis", "given": "Sara", "initials": "S"}], "type": "journal-article", "published": "2021-08-12", "journal": {"title": "Eur Respir J", "issn": "0903-1936", "pages": "2101063", "issn-l": null}, "abstract": null, "doi": "10.1183/13993003.01063-2021", "pmid": null, "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-13T12:02:19.682Z", "modified": "2021-08-13T12:02:19.748Z"}, {"entity": "publication", "iuid": "8459545312984087acc8365e1a3b8290", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8459545312984087acc8365e1a3b8290.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8459545312984087acc8365e1a3b8290"}}, "title": "Post-Covid-19 Tachycardia Syndrome: A distinct phenotype of Post-acute Covid-19 Syndrome.", "authors": [{"family": "St\u00e5hlberg", "given": "Marcus", "initials": "M"}, {"family": "Reistam", "given": "Ulrika", "initials": "U"}, {"family": "Fedorowski", "given": "Artur", "initials": "A"}, {"family": "Villacorta", "given": "Humberto", "initials": "H"}, {"family": "Horiuchi", "given": "Yu", "initials": "Y"}, {"family": "Bax", "given": "Jeroen", "initials": "J"}, {"family": "Pitt", "given": "Bertram", "initials": "B"}, {"family": "Matskeplishvili", "given": "Simon", "initials": "S"}, {"family": "L\u00fcscher", "given": "Thomas F", "initials": "TF"}, {"family": "Weichert", "given": "Immo", "initials": "I"}, {"family": "Thani", "given": "Khalid Bin", "initials": "KB"}, {"family": "Maisel", "given": "Alan", "initials": "A"}], "type": "journal article", "published": "2021-08-11", "journal": {"title": "Am J Med", "issn": "1555-7162", "issn-l": null}, "abstract": "In this paper we highlight the presence of tachycardia in Post-acute Covid-19 Syndrome by introducing a new label for this phenomenon: Post-covid-19 tachycardia syndrome and argue that this constitutes a phenotype or sub-syndrome in PACS. We also discuss epidemiology, putative mechanisms, treatment options and future research directions in this novel clinical syndrome.", "doi": "10.1016/j.amjmed.2021.07.004", "pmid": "34390682", "labels": {"Type: Review": null, "Category: Post-COVID": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0002-9343(21)00472-1"}], "notes": [], "created": "2021-08-16T09:19:42.823Z", "modified": "2021-08-16T09:19:42.827Z"}, {"entity": "publication", "iuid": "662c8a91e61245ef9e66193caf062884", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/662c8a91e61245ef9e66193caf062884.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/662c8a91e61245ef9e66193caf062884"}}, "title": "Ovulatory upregulation of angiotensin-converting enzyme 2, a receptor for SARS-CoV-2, in dominant follicles of the human ovary.", "authors": [{"family": "Choi", "given": "Yohan", "initials": "Y"}, {"family": "Jeon", "given": "Hayce", "initials": "H"}, {"family": "Br\u00e4nnstr\u00f6m", "given": "Mats", "initials": "M"}, {"family": "Akin", "given": "James W", "initials": "JW"}, {"family": "Curry", "given": "Thomas E", "initials": "TE"}, {"family": "Jo", "given": "Misung", "initials": "M"}], "type": "journal article", "published": "2021-08-11", "journal": {"title": "Fertil Steril", "issn": "1556-5653", "issn-l": null}, "abstract": "To determine the temporal expression of angiotensin-converting enzyme 2 (ACE2), a receptor for SARS-CoV-2, in dominant follicles throughout the periovulatory period in women and the regulatory mechanisms underlying ACE2 expression in human granulosa/lutein cells (hGLC).\n\nExperimental prospective clinical study and laboratory-based investigation.\n\nUniversity Medical Center and private in vitro fertilization center.\n\nThirty premenopausal women undergoing surgery for tubal ligation and 16 premenopausal women undergoing in vitro fertilization.\n\nAdministration of human chorionic gonadotropin (hCG) and harvesting of preovulatory/ovulatory follicles by timed laparoscopy, and collection of granulosa/lutein cells and cumulus cells at the time of oocyte retrieval.\n\nExpression and localization of ACE2 in granulosa cells and dominant follicles collected throughout the periovulatory period of the menstrual cycle and in hGLC using quantitative polymerase chain reaction, immunoblotting, and immunohistochemistry.\n\nACE2 expression (mRNA and protein) is up-regulated in human ovulatory follicles after administration of hCG. ACE2 expression was higher in cumulus cells than in granulosa cells. hCG increased the expression of ACE2 in primary hGLC cultures; the increase was inhibited by RU486 (an antagonist for progesterone receptor and glucocorticoid receptor) and CORT125281 (a selective glucocorticoid receptor antagonist), but not by AG1478 (an EGF receptor tyrosine kinase inhibitor) or by dexamethasone.\n\nThe hormone-regulated expression of ACE2 in granulosa cells suggests a potential role of ACE2 in the ovulatory process. These data also imply the possible impact of COVID-19 on a vital cyclic event of ovarian function and thus on women's overall reproductive health. However, SAR-CoV-2 infection in ovarian cells in vivo or in vitro has yet to be determined.", "doi": "10.1016/j.fertnstert.2021.08.009", "pmid": "34538460", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0015-0282(21)01932-4"}, {"db": "pmc", "key": "PMC8354803"}], "notes": [], "created": "2021-10-10T15:33:54.875Z", "modified": "2021-10-10T15:33:54.901Z"}, {"entity": "publication", "iuid": "e429c397680849fa8fb8e42ec170e9a7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e429c397680849fa8fb8e42ec170e9a7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e429c397680849fa8fb8e42ec170e9a7"}}, "title": "Healthcare professionals' experiences during the initial stage of the COVID-19 pandemic in the intensive care unit: A qualitative study.", "authors": [{"family": "Mortensen", "given": "Camilla Bekker", "initials": "CB"}, {"family": "Zachodnik", "given": "Josephine", "initials": "J"}, {"family": "Caspersen", "given": "Sidsel Fjordbak", "initials": "SF"}, {"family": "Geisler", "given": "Anja", "initials": "A"}], "type": "journal article", "published": "2021-08-11", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "pages": "103130", "issn-l": null}, "abstract": "The COVID-19 pandemic called for rapidly considerable changes in the healthcare system. Healthcare professionals from different departments within the hospital settings were enrolled in the emergency preparedness. This study, therefore, aimed to explore the healthcare professionals' experiences attending the ICU-preparedness and caring for patients with COVID-19 during the initial stage of the pandemic.\n\nA descriptive explorative qualitative study was conducted by interviewing healthcare professionals during spring 2020, exploring their experiences as part of the ICU-preparedness team and caring for patients with COVID-19 in the ICU. Healthcare professionals from different departments were recruited by purposive sampling. The interviews were transcribed verbatim and analysed using content analysis.\n\nSixteen nurses and four physicians from a university hospital in Denmark participated. The analysis revealed three main themes and eight sub-themes. The main themes were (1) Professionalism in work-life (adaption, the patient's welfare, insecurity, and security), (2) Community Spirit (responsibility and contribution), and (3) Institutional organisation (the role of management, loss of freedom, and information).\n\nDespite work specialities and professions, the participants reported a uniformity of similar experiences of uncertainties, but also a sense of community arose during the first phase of COVID-19.\n\nTo ensure resilience and mental health, and well-being for the healthcare professionals, comprehensive support should be provided. Guidelines for interventions and training are necessary to promote preparedness and reduce psychological stress.", "doi": "10.1016/j.iccn.2021.103130", "pmid": "34538544", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(21)00119-1"}, {"db": "pmc", "key": "PMC8354791"}], "notes": [], "created": "2021-10-10T15:34:21.827Z", "modified": "2021-10-10T15:34:21.840Z"}, {"entity": "publication", "iuid": "3bda20886f3740a59941eacb08330d9a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3bda20886f3740a59941eacb08330d9a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3bda20886f3740a59941eacb08330d9a"}}, "title": "Fathering Practices in Sweden During the COVID-19: Experiences of Syrian Refugee Fathers.", "authors": [{"family": "Wiss\u00f6", "given": "Ther\u00e9se", "initials": "T"}, {"family": "B\u00e4ck-Wiklund", "given": "Margareta", "initials": "M"}], "type": "journal article", "published": "2021-08-11", "journal": {"title": "Front Sociol", "issn": "2297-7775", "issn-l": null, "volume": "6", "issue": null, "pages": "721881"}, "abstract": "This article explores fathering practices among Syrian refugee families in Sweden. Syrian refugees provide an example of people who migrated because of a single major event: the war in Syria. The article examines the impact of the COVID-19 pandemic on fathering practices. The Swedish COVID-19 strategy differed from those adopted in many other countries. Lockdowns were minimal and were not stringently enforced, based on the assumption that individuals would trust the authorities and would take personal responsibility for complying with their guidelines and recommendations. Previous research suggests that migrants and other vulnerable groups were not always well informed about the public policies introduced prior to and during the pandemic. The article draws on empirical data from a wider research project on the family lives of Syrian migrants in Sweden. The authors present their findings from an analysis of eleven ethnographically informed semi-structured interviews, carried out before and during the pandemic, with married fathers who had been living in Sweden for several years. In this article, they focus on three cases representing fathers with varied educational backgrounds and employment histories. These families had in common what are considered by Swedish standards to be overcrowded living conditions; they were forced to accept close family proximity, both physically and emotionally, as they no longer had the supportive networks they were used to in Syria. The three fathers were found to rely more heavily on information provided by the people with whom they were in contact in Sweden than on policies and recommendations from the authorities. These findings confirmed that the previous experiences among refugees of shifting policies regarding migration and integration had lowered their trust in government. They had learnt that they needed to rely on mutual dependency not only between spouses, but also between parents and children.", "doi": "10.3389/fsoc.2021.721881", "pmid": "34458362", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "721881"}, {"db": "pmc", "key": "PMC8385311"}], "notes": [], "created": "2021-09-01T07:47:01.167Z", "modified": "2022-11-23T08:53:49.788Z"}, {"entity": "publication", "iuid": "63111781bc1e427aa45a890921711381", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63111781bc1e427aa45a890921711381.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63111781bc1e427aa45a890921711381"}}, "title": "Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling.", "authors": [{"family": "Mishra", "given": "Swapnil", "initials": "S", "orcid": "0000-0002-8759-5902", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9090a94ef6b43e59561319e56b1fcc8.json"}}, {"family": "Scott", "given": "James A", "initials": "JA"}, {"family": "Laydon", "given": "Daniel J", "initials": "DJ", "orcid": "0000-0003-4270-3321", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/941e87bd83ed4474869d63d345cf8ff4.json"}}, {"family": "Flaxman", "given": "Seth", "initials": "S"}, {"family": "Gandy", "given": "Axel", "initials": "A"}, {"family": "Mellan", "given": "Thomas A", "initials": "TA"}, {"family": "Unwin", "given": "H Juliette T", "initials": "HJT", "orcid": "0000-0002-9120-4003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29efd6265a564f1890678af46df4ab5e.json"}}, {"family": "Vollmer", "given": "Michaela", "initials": "M"}, {"family": "Coupland", "given": "Helen", "initials": "H"}, {"family": "Ratmann", "given": "Oliver", "initials": "O"}, {"family": "Monod", "given": "Melodie", "initials": "M"}, {"family": "Zhu", "given": "Harrison H", "initials": "HH"}, {"family": "Cori", "given": "Anne", "initials": "A"}, {"family": "Gaythorpe", "given": "Katy A M", "initials": "KAM", "orcid": "0000-0003-3734-9081", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/faae9aff1d7c4b948de39fce64a55bc3.json"}}, {"family": "Whittles", "given": "Lilith K", "initials": "LK", "orcid": "0000-0002-8913-0391", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4635744009424fb5b72184abad9929ff.json"}}, {"family": "Whittaker", "given": "Charles", "initials": "C"}, {"family": "Donnelly", "given": "Christl A", "initials": "CA", "orcid": "0000-0002-0195-2463", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5e672e1b59c4d9c8d6c5ba3e5280dd9.json"}}, {"family": "Ferguson", "given": "Neil M", "initials": "NM", "orcid": "0000-0002-1154-8093", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34d57563a33a4be7be974488684afbb7.json"}}, {"family": "Bhatt", "given": "Samir", "initials": "S"}], "type": "comparative study", "published": "2021-08-11", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "16342", "issn-l": "2045-2322"}, "abstract": "The UK and Sweden have among the worst per-capita COVID-19 mortality in Europe. Sweden stands out for its greater reliance on voluntary, rather than mandatory, control measures. We explore how the timing and effectiveness of control measures in the UK, Sweden and Denmark shaped COVID-19 mortality in each country, using a counterfactual assessment: what would the impact have been, had each country adopted the others' policies? Using a Bayesian semi-mechanistic model without prior assumptions on the mechanism or effectiveness of interventions, we estimate the time-varying reproduction number for the UK, Sweden and Denmark from daily mortality data. We use two approaches to evaluate counterfactuals which transpose the transmission profile from one country onto another, in each country's first wave from 13th March (when stringent interventions began) until 1st July 2020. UK mortality would have approximately doubled had Swedish policy been adopted, while Swedish mortality would have more than halved had Sweden adopted UK or Danish strategies. Danish policies were most effective, although differences between the UK and Denmark were significant for one counterfactual approach only. Our analysis shows that small changes in the timing or effectiveness of interventions have disproportionately large effects on total mortality within a rapidly growing epidemic.", "doi": "10.1038/s41598-021-95699-9", "pmid": "34381102", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8358009"}, {"db": "pii", "key": "10.1038/s41598-021-95699-9"}], "notes": [], "created": "2023-01-13T13:42:29.507Z", "modified": "2023-01-13T13:42:29.715Z"}, {"entity": "publication", "iuid": "b476270647504837acd317ffe5bf0994", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b476270647504837acd317ffe5bf0994.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b476270647504837acd317ffe5bf0994"}}, "title": "Soft law and individual responsibility: a review of the Swedish policy response to COVID-19.", "authors": [{"family": "Winblad", "given": "Ulrika", "initials": "U", "orcid": "0000-0002-3921-5522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af163cdcd01e4e348be01c344085ef2e.json"}}, {"family": "Swenning", "given": "Anna-Karin", "initials": "A"}, {"family": "Spangler", "given": "Douglas", "initials": "D"}], "type": "journal article", "published": "2021-08-10", "journal": {"title": "Health Econ Policy Law", "issn": "1744-134X", "issn-l": null, "volume": null, "issue": null, "pages": "1-14"}, "abstract": "Sweden's coronavirus disease 2019 (COVID-19) response, initially based largely on voluntary measures, has evoked strong reactions nationally and internationally. In this study, we describe Sweden's national policy response with regard to the general public, the community and the health care system, with a focus on how the response changed from March 2020 to June 2021. A number of factors contributed to Sweden's choice of policy response, including its existing legal framework, independent expert agencies and its decentralized, multi-level health care governance system. Challenges to the health- and elder care system during the pandemic, such as the need to increase intensive care- and testing capacity, and to ensure the safety of the elderly were addressed largely at the regional and local levels, with national authorities assuming a primarily coordinative role. Although the overall response based on voluntary compliance has persisted, the national government started to take a more prominent role in public messaging, and in enacting legally binding restrictions during subsequent waves of the pandemic. This study illustrates that not only policy responses, but also the fundamental structure of the health- and elder care system and its governance should be considered when evaluating the impact of the COVID-19 pandemic.", "doi": "10.1017/S1744133121000256", "pmid": "34372959", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1744133121000256"}, {"db": "pmc", "key": "PMC8387683"}], "notes": [], "created": "2021-08-11T14:30:17.809Z", "modified": "2021-11-18T13:32:02.858Z"}, {"entity": "publication", "iuid": "ad4e8a3cf6f241cb964898f14cfba40b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ad4e8a3cf6f241cb964898f14cfba40b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ad4e8a3cf6f241cb964898f14cfba40b"}}, "title": "Remdesivir in the COVID-19 Pandemic: An Analysis of Spontaneous Reports in VigiBase During 2020.", "authors": [{"family": "Rocca", "given": "Elena", "initials": "E"}, {"family": "Gauffin", "given": "Oskar", "initials": "O"}, {"family": "Savage", "given": "Ruth", "initials": "R"}, {"family": "Vidlin", "given": "Sara Hedfors", "initials": "SH"}, {"family": "Grundmark", "given": "Birgitta", "initials": "B", "orcid": "0000-0002-2799-9374", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af41b5a50729439f9ee9454393af8cdc.json"}}], "type": "journal article", "published": "2021-08-10", "journal": {"title": "Drug Saf", "issn": "1179-1942", "issn-l": "0114-5916"}, "abstract": "The safety profile of remdesivir, conditionally approved for COVID-19, was limited at its 2020 introduction. Adverse drug reactions (ADRs) for medicines are collected in VigiBase, the WHO Global Database of Individual Case Safety Reports (ICSRs).\n\nThis study aimed to provide a descriptive analysis of COVID-19 ICSR data focusing on remdesivir, including a disproportionality analysis (DA) of ADRs.\n\nA dedicated algorithm enabled retrieval of all COVID-19 treatment-specific ICSRs. A severity algorithm based on co-reported medicines and symptoms enabled selection of tocilizumab with its well established safety profile as comparator for remdesivir. Descriptive statistics were used for general ICSR demographics for all COVID-19-specific medicines, remdesivir and tocilizumab individually and furthermore to present treatment patterns of medicines co-reported with remdesivir. A COVID-19 indication-focused DA was deployed to minimize confounding from underlying polysymptomatic disease.\n\n14,574 COVID-19-related ICSRs were entered into VigiBase during 2020. Remdesivir was the most common medicine reported. Of 4944 remdesivir ICSRs, where tocilizumab was not co-reported, 93% described remdesivir as the sole suspect medicine. Sixty percent of ICSRs concerned males, median age was 63 years and the majority originated from the Americas (72%). In 1089 (21%) of remdesivir ICSRs, data indicated severe/critical disease. Co-reported medicines peaked during the first 3 days of remdesivir treatment. The DA for the established tocilizumab and the new remdesivir were mainly in line with the safety profiles for both medicines but suggested new safety concerns. The most reported ADRs for remdesivir represented liver dysfunction, kidney injury, death and bradycardia.\n\nGlobal COVID-19-related ADR reporting proved useful in providing information on ADRs as well as on treatment patterns in this patient group. Indication-focused disproportionality analysis, together with the use of a comparator with a known safety profile, proved effective in identifying known safety information and suggested new safety concerns for remdesivir.", "doi": "10.1007/s40264-021-01091-x", "pmid": "34374967", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40264-021-01091-x"}], "notes": [], "created": "2021-08-11T14:28:49.961Z", "modified": "2021-08-11T14:29:37.634Z"}, {"entity": "publication", "iuid": "594d9547784441abb908eeaf85ed0e79", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/594d9547784441abb908eeaf85ed0e79.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/594d9547784441abb908eeaf85ed0e79"}}, "title": "Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites.", "authors": [{"family": "Hoffmann", "given": "David", "initials": "D"}, {"family": "Mereiter", "given": "Stefan", "initials": "S"}, {"family": "Jin Oh", "given": "Yoo", "initials": "Y"}, {"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Elder", "given": "Elizabeth", "initials": "E"}, {"family": "Zhu", "given": "Rong", "initials": "R"}, {"family": "Canena", "given": "Daniel", "initials": "D"}, {"family": "Hain", "given": "Lisa", "initials": "L"}, {"family": "Laurent", "given": "Elisabeth", "initials": "E"}, {"family": "Gr\u00fcnwald-Gruber", "given": "Clemens", "initials": "C"}, {"family": "Klausberger", "given": "Miriam", "initials": "M"}, {"family": "Jonsson", "given": "Gustav", "initials": "G"}, {"family": "Kellner", "given": "Max J", "initials": "MJ"}, {"family": "Novatchkova", "given": "Maria", "initials": "M"}, {"family": "Ticevic", "given": "Melita", "initials": "M"}, {"family": "Chabloz", "given": "Antoine", "initials": "A"}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G"}, {"family": "Hagelkruys", "given": "Astrid", "initials": "A"}, {"family": "Altmann", "given": "Friedrich", "initials": "F"}, {"family": "Mach", "given": "Lukas", "initials": "L"}, {"family": "Stadlmann", "given": "Johannes", "initials": "J"}, {"family": "Oostenbrink", "given": "Chris", "initials": "C"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Hinterdorfer", "given": "Peter", "initials": "P"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}], "type": "journal article", "published": "2021-08-10", "journal": {"title": "EMBO J", "issn": "1460-2075", "pages": "e108375", "issn-l": null}, "abstract": "New SARS-CoV-2 variants are continuously emerging with critical implications for therapies or vaccinations. The 22 N-glycan sites of Spike remain highly conserved among SARS-CoV-2 variants, opening an avenue for robust therapeutic intervention. Here we used a comprehensive library of mammalian carbohydrate-binding proteins (lectins) to probe critical sugar residues on the full-length trimeric Spike and the receptor binding domain (RBD) of SARS-CoV-2. Two lectins, Clec4g and CD209c, were identified to strongly bind to Spike. Clec4g and CD209c binding to Spike was dissected and visualized in real time and at single molecule resolution using atomic force microscopy. 3D modelling showed that both lectins can bind to a glycan within the RBD-ACE2 interface and thus interferes with Spike binding to cell surfaces. Importantly, Clec4g and CD209c significantly reduced SARS-CoV-2 infections. These data report the first extensive map and 3D structural modelling of lectin-Spike interactions and uncovers candidate receptors involved in Spike binding and SARS-CoV-2 infections. The capacity of CLEC4G and mCD209c lectins to block SARS-CoV-2 viral entry holds promise for pan-variant therapeutic interventions.", "doi": "10.15252/embj.2021108375", "pmid": "34375000", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://covid.molssi.org//models/#spike-protein-in-complex-with-human-ace2-spike-spike-binding%29.", "description": "Structural models for used in virtual screening"}], "notes": [], "created": "2021-08-11T14:27:59.675Z", "modified": "2021-09-09T07:13:12.326Z"}, {"entity": "publication", "iuid": "862ac2f181b7434fb4559dff0c1b0e99", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/862ac2f181b7434fb4559dff0c1b0e99.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/862ac2f181b7434fb4559dff0c1b0e99"}}, "title": "The reproductive number of the Delta variant of SARS-CoV-2 is far higher compared to the ancestral SARS-CoV-2 virus.", "authors": [{"family": "Liu", "given": "Ying", "initials": "Y"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}], "type": "journal article", "published": "2021-08-09", "journal": {"title": "J Travel Med", "issn": "1708-8305", "issn-l": null}, "abstract": "The Delta variant is now replacing all other SARS-CoV-2 variants. We found a mean R0 of 5.08 which is much higher than the R0 of the ancestral strain of 2.79. Rapidly ramping up vaccine coverage rates while enhancing public health and social measures is now even more urgent and important.", "doi": "10.1093/jtm/taab124", "pmid": "34369565", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6346388"}], "notes": [], "created": "2021-08-11T14:33:55.820Z", "modified": "2021-08-11T14:33:55.832Z"}, {"entity": "publication", "iuid": "7bd8c3c52c7a410d990755358d816fdb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7bd8c3c52c7a410d990755358d816fdb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7bd8c3c52c7a410d990755358d816fdb"}}, "title": "Initial impact of SARS-Cov-2 vaccination on healthcare workers in Italy- Update on the 28th of March 2021.", "authors": [{"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Spuri", "given": "Matteo", "initials": "M"}, {"family": "D'Ancona", "given": "Fortunato", "initials": "F"}, {"family": "Filia", "given": "Antonietta", "initials": "A"}, {"family": "Rota", "given": "Maria Cristina", "initials": "MC"}, {"family": "Petrone", "given": "Daniele", "initials": "D"}, {"family": "Vescio", "given": "Maria Fenicia", "initials": "MF"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}], "type": "journal article", "published": "2021-08-09", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null, "volume": "39", "issue": "34", "pages": "4788-4792"}, "abstract": "In Italy, the COVID-19 vaccination campaign started in December 2020 with the vaccination of healthcare workers (HCW). To analyse the real-life impact that vaccination is having on this population group, we measured the association between week of diagnosis and HCW status using log-binomial regression. By the week 22-28 March, we observed a 74% reduction (PPR 0.26; 95% CI 0.22-0.29) in the proportion of cases reported as HCW and 81% reduction in the proportion of symptomatic cases reported as HCW, compared with the week with the lowest proportion of cases among HCWs prior to the vaccination campaign (31 August-7 September). The reduction, both in relative and absolute terms, of COVID-19 cases in HCWs that started around 30 days after the start of the vaccination campaign suggest that COVID-19 vaccines are being effective in preventing infection in this group.", "doi": "10.1016/j.vaccine.2021.07.003", "pmid": "34253419", "labels": {"Category: Public Health": null, "Type: Journal article": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(21)00862-8"}, {"db": "pmc", "key": "PMC8260579"}], "notes": [], "created": "2021-08-06T07:34:29.106Z", "modified": "2021-12-07T15:29:24.754Z"}, {"entity": "publication", "iuid": "d8212176c72a4096a4852c29880b2ade", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d8212176c72a4096a4852c29880b2ade.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d8212176c72a4096a4852c29880b2ade"}}, "title": "Sample-to-answer COVID-19 nucleic acid testing using a low-cost centrifugal microfluidic platform with bead-based signal enhancement and smartphone read-out.", "authors": [{"family": "Soares", "given": "Ruben R G", "initials": "RRG", "orcid": "0000-0001-5958-5232", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2fc2815bc25c4fb78df63294947ee184.json"}}, {"family": "Akhtar", "given": "Ahmad S", "initials": "AS", "orcid": "0000-0002-4560-4735", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc3276d3eaca462fb80c2033d7bc0104.json"}}, {"family": "Pinto", "given": "In\u00eas F", "initials": "IF", "orcid": "0000-0002-9714-4742", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f94e94cf2e14c3cb4ce6f8d7235ea8b.json"}}, {"family": "Lapins", "given": "Noa", "initials": "N"}, {"family": "Barrett", "given": "Donal", "initials": "D"}, {"family": "Sandh", "given": "Gustaf", "initials": "G"}, {"family": "Yin", "given": "Xiushan", "initials": "X"}, {"family": "Pelechano", "given": "Vicent", "initials": "V", "orcid": "0000-0002-9415-788X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce53b4c829e547399014c2d8042dde35.json"}}, {"family": "Russom", "given": "Aman", "initials": "A", "orcid": "0000-0002-0242-358X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a36512bc999441bfa671e316fa9e89b4.json"}}], "type": "journal article", "published": "2021-08-07", "journal": {"title": "Lab Chip", "issn": "1473-0189", "issn-l": null, "volume": "21", "issue": "15", "pages": "2932-2944"}, "abstract": "With its origin estimated around December 2019 in Wuhan, China, the ongoing SARS-CoV-2 pandemic is a major global health challenge. The demand for scalable, rapid and sensitive viral diagnostics is thus particularly pressing at present to help contain the rapid spread of infection and prevent overwhelming the capacity of health systems. While high-income countries have managed to rapidly expand diagnostic capacities, such is not the case in resource-limited settings of low- to medium-income countries. Aiming at developing cost-effective viral load detection systems for point-of-care COVID-19 diagnostics in resource-limited and resource-rich settings alike, we report the development of an integrated modular centrifugal microfluidic platform to perform loop-mediated isothermal amplification (LAMP) of viral RNA directly from heat-inactivated nasopharyngeal swab samples. The discs were pre-packed with dried n-benzyl-n-methylethanolamine modified agarose beads used to selectively remove primer dimers, inactivate the reaction post-amplification and allowing enhanced fluorescence detection via a smartphone camera. Sample-to-answer analysis within 1 hour from sample collection and a detection limit of approximately 100 RNA copies in 10 \u03bcL reaction volume were achieved. The platform was validated with a panel of 162 nasopharyngeal swab samples collected from patients with COVID-19 symptoms, providing a sensitivity of 96.6% (82.2-99.9%, 95% CI) for samples with Ct values below 26 and a specificity of 100% (90-100%, 95% CI), thus being fit-for-purpose to diagnose patients with a high risk of viral transmission. These results show significant promise towards bringing routine point-of-care COVID-19 diagnostics to resource-limited settings.", "doi": "10.1039/d1lc00266j", "pmid": "34114589", "labels": {"Research Area: Diagnostics for virus": null, "Funder: KAW/SciLifeLab": null, "Funder: H2020": null, "Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-06T14:40:58.154Z", "modified": "2021-08-23T12:18:50.531Z"}, {"entity": "publication", "iuid": "03634cc797f44a70b47acd4b13e62fd1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/03634cc797f44a70b47acd4b13e62fd1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/03634cc797f44a70b47acd4b13e62fd1"}}, "title": "Correction to: Perceptions and effects of COVID-19 related information in Denmark and Sweden - a web-based survey about COVID-19 and social media.", "authors": [{"family": "Stjernsw\u00e4rd", "given": "Sigrid", "initials": "S", "orcid": "0000-0002-7152-9206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cda8ee3ae8564252aa6ffe2ab219ada8.json"}}, {"family": "Ivert", "given": "Anna-Karin", "initials": "AK", "orcid": "0000-0001-7749-9549", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fec7c74c7fa4df4849474c8c3a9e8a7.json"}}, {"family": "Glasdam", "given": "Stinne", "initials": "S", "orcid": "0000-0002-0893-3054", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c56787745d04e05ad85e53ce8df6061.json"}}], "type": "published erratum", "published": "2021-08-07", "journal": {"title": "Z Gesundh Wiss", "issn": "2198-1833", "pages": "1", "issn-l": null}, "abstract": "[This corrects the article DOI: 10.1007/s10389-021-01539-5.].", "doi": "10.1007/s10389-021-01642-7", "pmid": "34395176", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "1642"}, {"db": "pmc", "key": "PMC8346338"}], "notes": [], "created": "2021-08-17T06:43:31.753Z", "modified": "2021-08-17T06:43:31.856Z"}, {"entity": "publication", "iuid": "b444c703d7a148c4883271a70fd7e27f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b444c703d7a148c4883271a70fd7e27f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b444c703d7a148c4883271a70fd7e27f"}}, "title": "Voters' view of leaders during the Covid-19 crisis: Quantitative analysis of keyword descriptions provides strength and direction of evaluations.", "authors": [{"family": "Fred\u00e9n", "given": "Annika", "initials": "A", "orcid": "0000-0003-0820-8626", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c0b021ac0de4dfdbc719292533683d6.json"}}, {"family": "Sikstr\u00f6m", "given": "Sverker", "initials": "S"}], "type": "journal article", "published": "2021-08-06", "journal": {"title": "Soc Sci Q", "issn": "0038-4941", "issn-l": null}, "abstract": "Previous research suggests that governments usually gain support during crises such as the Covid-19. However, these findings are based on rating scales that only allow us to measure the strength of this support. This article proposes a new measure of how voters evaluate Prime Ministers (PM) by asking for descriptive keywords that are analyzed by natural language processing.\n\nBy collecting a representative sample of citizens' own key words describing their PM in 15 countries in Europe during the outbreak of Covid-19, and analyzing these by latent semantic analysis and a multiple OLS regression, we could quantify the strength and direction of voters' view.\n\nThe strength analysis supported previous studies that describing the PM with positive words was strongly associated with vote intention. Furthermore, a change in the direction of the attitudes from \"good\" to \"honest\" was found. A new finding was that the pandemic was associated with an increase in polarization.\n\nThe keyword evaluation analysis provides opportunities of evaluating both strength and direction of voters' view of their PM, where we show new results related to increased polarization and shift in the direction of attitudes.", "doi": "10.1111/ssqu.13036", "pmid": "34548706", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "SSQU13036"}, {"db": "pmc", "key": "PMC8447460"}], "notes": [], "created": "2021-10-27T05:13:02.985Z", "modified": "2021-10-27T05:13:03.055Z"}, {"entity": "publication", "iuid": "76fa32053cc14e888d63db4413367003", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76fa32053cc14e888d63db4413367003.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76fa32053cc14e888d63db4413367003"}}, "title": "Secondary bacterial infections and antimicrobial resistance in COVID-19: comparative evaluation of pre-pandemic and pandemic-era, a retrospective single center study.", "authors": [{"family": "Karata\u015f", "given": "Mustafa", "initials": "M", "orcid": "0000-0002-2464-0593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe5e7d7c255f4b6394d7d0712c8af986.json"}}, {"family": "Ya\u015far-Duman", "given": "Melike", "initials": "M", "orcid": "0000-0001-8913-2314", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eee2e7153be4128987516582c5f82a5.json"}}, {"family": "T\u00fcnger", "given": "Alper", "initials": "A", "orcid": "0000-0002-1644-8833", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2370d67703347be8fb05a1fc5c3fabe.json"}}, {"family": "\u00c7illi", "given": "Feriha", "initials": "F", "orcid": "0000-0003-3993-3396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0de7edbbcdda42f5a81352fb68d95bfe.json"}}, {"family": "Aydemir", "given": "\u015e\u00f6hret", "initials": "\u015e", "orcid": "0000-0001-8354-9100", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf04dbb9c5404c268f1a5b2497bbe24d.json"}}, {"family": "\u00d6zenci", "given": "Volkan", "initials": "V", "orcid": "0000-0002-8069-4027", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04a5e899bc05457496095b831df1391a.json"}}], "type": "journal article", "published": "2021-08-05", "journal": {"title": "Ann Clin Microbiol Antimicrob", "issn": "1476-0711", "volume": "20", "issue": "1", "pages": "51", "issn-l": null}, "abstract": "In this study, we aimed to evaluate the epidemiology and antimicrobial resistance (AMR) patterns of bacterial pathogens in COVID-19 patients and to compare the results with control groups from the pre-pandemic and pandemic era.\n\nMicrobiological database records of all the COVID-19 diagnosed patients in the Ege University Hospital between March 15, 2020, and June 15, 2020, evaluated retrospectively. Patients who acquired secondary bacterial infections (SBIs) and bacterial co-infections were analyzed. Etiology and AMR data of the bacterial infections were collected. Results were also compared to control groups from pre-pandemic and pandemic era data.\n\nIn total, 4859 positive culture results from 3532 patients were analyzed. Fifty-two (3.59%) patients had 78 SBIs and 38 (2.62%) patients had 45 bacterial co-infections among 1447 COVID-19 patients. 22/85 (25.88%) patients died who had bacterial infections. The respiratory culture-positive sample rate was 39.02% among all culture-positive samples in the COVID-19 group. There was a significant decrease in extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales (8.94%) compared to samples from the pre-pandemic (20.76%) and pandemic era (20.74%) (p = 0.001 for both comparisons). Interestingly, Acinetobacter baumannii was the main pathogen in the respiratory infections of COVID-19 patients (9.76%) and the rate was significantly higher than pre-pandemic (3.49%, p < 0.002) and pandemic era control groups (3.11%, p < 0.001).\n\nDue to the low frequency of SBIs reported during the ongoing pandemic, a more careful and targeted antimicrobial prescription should be taken. While patients with COVID-19 had lower levels of ESBL-producing Enterobacterales, the frequency of multidrug-resistant (MDR) A. baumannii is higher.", "doi": "10.1186/s12941-021-00454-7", "pmid": "34353332", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12941-021-00454-7"}, {"db": "pmc", "key": "PMC8340813"}], "notes": [], "created": "2021-08-11T14:42:06.234Z", "modified": "2021-08-11T14:42:06.390Z"}, {"entity": "publication", "iuid": "bf9ea7246bbc4f0bacd9505b617d039e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf9ea7246bbc4f0bacd9505b617d039e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf9ea7246bbc4f0bacd9505b617d039e"}}, "title": "Immunity to SARS-CoV-2 induced by infection or vaccination.", "authors": [{"family": "Castro Dopico", "given": "Xaquin", "initials": "X", "orcid": "0000-0002-9005-6774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/354c91b234fd4a039f85c13e7e4209c1.json"}}, {"family": "Ols", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-9784-7176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35eb7b8de6434661a729bab979f26c7d.json"}}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K", "orcid": "0000-0001-7679-9494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02d4d3d9ccc547f7ab18ba69493f6a34.json"}}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB", "orcid": "0000-0001-7255-9047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/891aa9ca3f604b7396a14d65a33c2187.json"}}], "type": "journal article", "published": "2021-08-05", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null}, "abstract": "Adaptive immune responses play critical roles in viral clearance and protection against re-infection, and SARS-CoV-2 is no exception. What is exceptional, is the rapid characterization of the immune response to the virus performed by researchers during the first 20 months of the pandemic. This has given us a more detailed understanding about SARS-CoV-2 than we have about many viruses that have been with us for a long time. Furthermore, effective COVID-19 vaccines were developed in record time, and their rollout worldwide is already making a significant difference, although major challenges remain in terms of equal access. The pandemic has engaged scientists and the public alike, and terms such as seroprevalence, neutralizing antibodies, antibody escape and vaccine certificates have become familiar to a broad community. Here, we review key findings concerning B cell and antibody (Ab) responses to SARS-CoV-2, focusing on non-severe cases and anti-spike (S) Ab responses in particular, the latter being central to protective immunity induced by infection or vaccination. The emergence of viral variants that have acquired mutations in S acutely highlights the need for continued characterization of both emerging variants and Ab responses against these during the evolving pathogen-immune system arms race.", "doi": "10.1111/joim.13372", "pmid": "34352148", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-08-06T08:55:00.572Z", "modified": "2021-08-06T08:55:00.672Z"}, {"entity": "publication", "iuid": "8918d87280614988a89a6fe124e69d32", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8918d87280614988a89a6fe124e69d32.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8918d87280614988a89a6fe124e69d32"}}, "title": "Higher rate of SARS-CoV-2 IgG seropositivity in hospital-based healthcare workers compared to elderly care staff in a Swedish low-prevalence region: a cross-sectional study.", "authors": [{"family": "Ocias", "given": "Lukas Frans", "initials": "LF"}, {"family": "Skogstam", "given": "Anna", "initials": "A"}, {"family": "Kjerstadius", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Lundin", "given": "Fredrik", "initials": "F"}, {"family": "Tevell", "given": "Staffan", "initials": "S", "orcid": "0000-0002-9213-9274", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12b1a3e80af94b3e8bbb3abbe247ecd0.json"}}], "type": "journal article", "published": "2021-08-05", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": "53", "issue": "12", "pages": "920-929"}, "abstract": "Previous seroprevalence studies have demonstrated higher anti-SARS-CoV-2 IgG seroprevalence in healthcare workers (HCWs) than in the background population during the first phase of the 2020 COVID-19 pandemic. These studies, however, focussed mainly on hospital employees.\r\n\r\nTo perform a cross-sectional study comparing the seroprevalence of hospital-based HCWs with those employed in elderly care (home care and nursing homes).\r\n\r\nEmployees (n = 4955) in the county of V\u00e4rmland, Sweden, were recruited between weeks 27 and 42 and tested for IgG antibodies against SARS-CoV-2. Serological results were combined with self-reported questionnaire data.\r\n\r\nIgG seroprevalence was 5.7% in the total group of HCWs, and was higher among those employed in hospital-based healthcare than among those working in elderly care (8.4% vs. 3.7%, p < .001). Being employed as an assistant nurse, working in a COVID-19 unit, and being exposed via co-workers or private acquaintances were all associated with IgG seropositivity.\r\n\r\nThe difference in seroprevalence between HCWs in the two settings suggests that not only the profession but also factors in the workplace environment may be of importance. As all studied exposures were associated with IgG seropositivity, and asymptomatic infection was detected in 7.5% of participants, preventing outbreaks among HCWs is challenging. Adequate use of personal protective equipment when working with patients regardless of COVID-19 status, source control in situations with co-workers in which distancing is not possible, and routines enabling symptomatic staff to isolate pending PCR results are required to prevent healthcare-associated outbreaks of COVID-19.", "doi": "10.1080/23744235.2021.1959949", "pmid": "34350813", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-06T08:55:23.783Z", "modified": "2021-11-18T13:25:45.879Z"}, {"entity": "publication", "iuid": "48eba88ae335446a9743f6fd56902d34", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/48eba88ae335446a9743f6fd56902d34.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/48eba88ae335446a9743f6fd56902d34"}}, "title": "Role of potential COVID-19 immune system associated genes and the potential pathways linkage with type-2 diabetes.", "authors": [{"family": "Helmi", "given": "Nawal", "initials": "N"}, {"family": "Alammari", "given": "Dalia", "initials": "D"}, {"family": "Mobashir", "given": "Mohammad", "initials": "M"}], "type": "journal article", "published": "2021-08-04", "journal": {"title": "Comb Chem High Throughput Screen", "issn": "1875-5402", "issn-l": null}, "abstract": "Coronavirus is an enveloped positive-sense RNA virus and is characterized by club-like spikes projecting from its surface which is commonly associated with acute respiratory infections in humans but its ability to infect multiple host species and multiple diseases brings it to a complex pathogen group. The frequent interactions of wild animals with humans it is more prevalent a common source of such infections and SARS-CoV and MERS-CoV are the zoonotic pathogens among the leading cause of severe respiratory diseases in humans.\n\nThe major purpose of this study was to study the gene expression profiling for those human samples which are infected with coronavirus or uninfected and compare the differential expression patterns and its functional impact.\n\nFor this purpose, the previously studied samples have been collected from public database and the study had been performed and it includes gene expression analysis, pathway analysis, and the network-level understanding. The analysis presents the data for the differentially expressed genes, enriched pathways and the networks for the potential genes and gene sets. In terms of gene expression and the linkage of COVID-19 with type-2 diabetes.\n\nWe observe that there are a large number of genes which show altered gene expression pattern than the normal for coronavirus infection while in terms of pathways it appears that there are few sets of functions which are affected due to altered gene expression and they infer to infection, inflammation, and the immune system.\n\nBased on our study, we conclude that the potential genes which are affected due to infection are NFKBIA, MYC, FOXO3, BIRC3, ICAM1, IL8, CXCL1/2/5, GADD45A, RELB, SGK1, AREG, BBC3, DDIT3/4, EGR1, MTHFD2, and SESN2 and the functional changes are mainly associated with these pathways TNF, cytokine, NF-kB, TLR, TCR, BCR, Foxo, and TGF signaling pathways are among them and there are additional pathways such as hippo signaling, apoptosis, estrogen signaling, regulating pluropotency of stem cells, ErbB, Wnt, p53, cAMP, MAPK, PI3K-AKT, oxidative phosphorylation, protein processing in endoplasmic reticulum, prolactin signaling, adipocytokine, neurotrophine signaling, and longevity regulating pathways. SMARCD3, PARL, GLIPR1, STAT2, PMAIP1, GP1BA, and TOX genes and PI3K-Akt, focal adhesion, Foxo, phagosome, adrenergic, osteoclast differentiation, platelet activation, insulin, cytokine-cytokine interaction, apoptosis, ECM, JAK-STAT, and oxytocine signaling appear as the linkage between COVID-19 and Type-2 diabetes.", "doi": "10.2174/1386207324666210804124416", "pmid": "34348612", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "CCHTS-EPUB-117038"}], "notes": [], "created": "2021-08-06T09:42:09.565Z", "modified": "2021-08-06T09:42:27.505Z"}, {"entity": "publication", "iuid": "5f9fb8c55117495fae2f3a7f43e2ea34", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f9fb8c55117495fae2f3a7f43e2ea34.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f9fb8c55117495fae2f3a7f43e2ea34"}}, "title": "Risk Perception and Protective Behavior in the Context of COVID-19: a Qualitative Exploration.", "authors": [{"family": "Siddiqui", "given": "Salma", "initials": "S"}, {"family": "Qamar", "given": "Azher Hameed", "initials": "AH", "orcid": "0000-0002-6137-6533", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27dff98f20e04eb3896dfab7e775c56f.json"}}], "type": "journal article", "published": "2021-08-04", "journal": {"title": "Asian Bioeth Rev", "issn": "1793-9453", "pages": "1-20", "issn-l": null}, "abstract": "As a result of the devastating health effects of the COVID-19 outbreak, the lockdown has been considered a safety measure in many countries. In Pakistan, the first case of COVID-19 was reported in February 2020. The purpose of this qualitative study was to investigate people's risk perception and protective behavior during the lockdown. Twenty-two (22) participants from eight big cities across Pakistan were interviewed. A six-step reflective thematic analysis was used for data analysis. The study focused on risk perception and protective behaviors. Our main analytical goal was to understand how risk perception shapes human behavior in the context of lockdown, pandemic-related information flow, and corresponding meaning-making. The study revealed that people influenced by information and advice campaigns form a perception of risk that has shaped their protective behavior. They used familiar means of coping with distress, including the search for strength through religious belief practices and following the precautions recommended by health professionals through the media.", "doi": "10.1007/s41649-021-00181-3", "pmid": "34367345", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "181"}, {"db": "pmc", "key": "PMC8335444"}], "notes": [], "created": "2021-08-11T14:34:57.786Z", "modified": "2021-08-11T14:36:16.611Z"}, {"entity": "publication", "iuid": "8050b697856f485ab35747b02497d14a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8050b697856f485ab35747b02497d14a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8050b697856f485ab35747b02497d14a"}}, "title": "Insomnia, anxiety, and depression during the COVID-19 pandemic: an international collaborative study.", "authors": [{"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Chung", "given": "Frances", "initials": "F"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "Penzel", "given": "Thomas", "initials": "T"}, {"family": "Ivers", "given": "Hans", "initials": "H"}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK"}, {"family": "Chan", "given": "Ngan Yin", "initials": "NY"}, {"family": "Merikanto", "given": "Ilona", "initials": "I"}, {"family": "Mota-Rolim", "given": "Sergio", "initials": "S"}, {"family": "Mac\u00eado", "given": "Tain\u00e1", "initials": "T"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L"}, {"family": "L\u00e9ger", "given": "Damien", "initials": "D"}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y"}, {"family": "Plazzi", "given": "Giuseppe", "initials": "G"}, {"family": "Nadorff", "given": "Michael R", "initials": "MR"}, {"family": "Bolstad", "given": "Courtney J", "initials": "CJ"}, {"family": "Sieminski", "given": "Mariusz", "initials": "M"}, {"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J"}, {"family": "Inoue", "given": "Yuchi", "initials": "Y"}, {"family": "Han", "given": "Fang", "initials": "F"}, {"family": "Espie", "given": "Colin A", "initials": "CA"}], "type": "journal article", "published": "2021-08-04", "journal": {"title": "Sleep Med", "issn": "1878-5506", "volume": "87", "pages": "38-45", "issn-l": null}, "abstract": "The COVID-19 pandemic has produced unprecedented changes in social, work, and leisure activities, which all have had major impact on sleep and psychological well-being. This study documented the prevalence of clinical cases of insomnia, anxiety, and depression and selected risk factors (COVID-19, confinement, financial burden, social isolation) during the first wave of the pandemic in 13 countries throughout the world.\n\nInternational, multi-center, harmonized survey of 22 330 adults (mean age = 41.9 years old, range 18-95; 65.6% women) from the general population in 13 countries and four continents. Participants were invited to complete a standardized web-based survey about sleep and psychological symptoms during the first wave of the COVID-19 pandemic from May to August 2020.\n\nClinical insomnia symptoms were reported by 36.7% (95% CI, 36.0-37.4) of respondents and 17.4% (95% CI, 16.9-17.9) met criteria for a probable insomnia disorder. There were 25.6% (95% CI, 25.0-26.2) with probable anxiety and 23.1% (95% CI, 22.5-23.6) with probable depression. Rates of insomnia symptoms (>40%) and insomnia disorder (>25%) were significantly higher in women, younger age groups, and in residents of Brazil, Canada, Norway, Poland, USA, and United Kingdom compared to residents from Asian countries (China and Japan, 8% for disorder and 22%-25% for symptoms) (all Ps < 0.01). Proportions of insomnia cases were significantly higher among participants who completed the survey earlier in the first wave of the pandemic relative to those who completed it later. Risks of insomnia were higher among participants who reported having had COVID-19, who reported greater financial burden, were in confinement for a period of four to five weeks, and living alone or with more than five people in same household. These associations remained significant after controlling for age, sex, and psychological symptoms.\n\nInsomnia, anxiety, and depression were very prevalent during the first wave of the COVID-19 pandemic. Public health prevention programs are needed to prevent chronicity and reduce long-term adverse outcomes associated with chronic insomnia and mental health problems.", "doi": "10.1016/j.sleep.2021.07.035", "pmid": "34508986", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1389-9457(21)00419-6"}], "notes": [], "created": "2021-09-13T06:31:15.919Z", "modified": "2021-09-13T06:31:15.942Z"}, {"entity": "publication", "iuid": "1180428124864f828411a81b51033272", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1180428124864f828411a81b51033272.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1180428124864f828411a81b51033272"}}, "title": "Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease.", "authors": [{"family": "Ricke-Hoch", "given": "Melanie", "initials": "M", "orcid": "0000-0001-5479-2275", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cd10380b93048dbae752276651ca2d3.json"}}, {"family": "Stelling", "given": "Elisabeth", "initials": "E"}, {"family": "Lasswitz", "given": "Lisa", "initials": "L"}, {"family": "Gunesch", "given": "Antonia P", "initials": "AP"}, {"family": "Kasten", "given": "Martina", "initials": "M"}, {"family": "Zapatero-Belinch\u00f3n", "given": "Francisco J", "initials": "FJ"}, {"family": "Brogden", "given": "Graham", "initials": "G"}, {"family": "Gerold", "given": "Gisa", "initials": "G", "orcid": "0000-0002-1326-5038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39af3df98cf14f96baa155798617841b.json"}}, {"family": "Pietschmann", "given": "Thomas", "initials": "T"}, {"family": "Montiel", "given": "Virginie", "initials": "V"}, {"family": "Balligand", "given": "Jean-Luc", "initials": "JL"}, {"family": "Facciotti", "given": "Federica", "initials": "F"}, {"family": "Hirsch", "given": "Emilio", "initials": "E"}, {"family": "Gausepohl", "given": "Thomas", "initials": "T", "orcid": "0000-0003-1669-5911", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd75a34037c14a1da4a85449ece2d242.json"}}, {"family": "Elbahesh", "given": "Husni", "initials": "H", "orcid": "0000-0003-1243-0967", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/822945b93dea44058ffd0881204ff742.json"}}, {"family": "Rimmelzwaan", "given": "Guus F", "initials": "GF"}, {"family": "H\u00f6fer", "given": "Anne", "initials": "A"}, {"family": "K\u00fchnel", "given": "Mark P", "initials": "MP"}, {"family": "Jonigk", "given": "Danny", "initials": "D"}, {"family": "Eigendorf", "given": "Julian", "initials": "J"}, {"family": "Tegtbur", "given": "Uwe", "initials": "U"}, {"family": "Mink", "given": "Lena", "initials": "L"}, {"family": "Scherr", "given": "Michaela", "initials": "M"}, {"family": "Illig", "given": "Thomas", "initials": "T"}, {"family": "Schambach", "given": "Axel", "initials": "A"}, {"family": "Pfeffer", "given": "Tobias J", "initials": "TJ"}, {"family": "Hilfiker", "given": "Andres", "initials": "A"}, {"family": "Haverich", "given": "Axel", "initials": "A"}, {"family": "Hilfiker-Kleiner", "given": "Denise", "initials": "D"}], "type": "journal article", "published": "2021-08-04", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "8", "pages": "e0255335", "issn-l": "1932-6203"}, "abstract": "The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds that risk-factors for severe COVID-19 disease courses, i.e. male sex, older age and sedentary life style are associated with higher prostaglandin E2 (PGE2) serum levels in blood samples from unaffected subjects. In COVID-19 patients, PGE2 blood levels are markedly elevated and correlate positively with disease severity. SARS-CoV-2 induces PGE2 generation and secretion in infected lung epithelial cells by upregulating cyclo-oxygenase (COX)-2 and reducing the PG-degrading enzyme 15-hydroxyprostaglandin-dehydrogenase. Also living human precision cut lung slices (PCLS) infected with SARS-CoV-2 display upregulated COX-2. Regular exercise in aged individuals lowers PGE2 serum levels, which leads to increased Paired-Box-Protein-Pax-5 (PAX5) expression, a master regulator of B-cell survival, proliferation and differentiation also towards long lived memory B-cells, in human pre-B-cell lines. Moreover, PGE2 levels in serum of COVID-19 patients lowers the expression of PAX5 in human pre-B-cell lines. The PGE2 inhibitor Taxifolin reduces SARS-CoV-2-induced PGE2 production. In conclusion, SARS-CoV-2, male sex, old age, and sedentary life style increase PGE2 levels, which may reduce the early anti-viral defense as well as the development of immunity promoting severe disease courses and multiple infections. Regular exercise and Taxifolin treatment may reduce these risks and prevent severe disease courses.", "doi": "10.1371/journal.pone.0255335", "pmid": "34347801", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-08028"}], "notes": [], "created": "2021-08-06T09:44:33.183Z", "modified": "2021-08-06T09:45:32.764Z"}, {"entity": "publication", "iuid": "b172f9cf78d446e6ac4011711b51c1cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b172f9cf78d446e6ac4011711b51c1cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b172f9cf78d446e6ac4011711b51c1cb"}}, "title": "A quantitative analysis of extension and distribution of lung injury in COVID-19: a prospective study based on chest computed tomography.", "authors": [{"family": "Pellegrini", "given": "Mariangela", "initials": "M"}, {"family": "Larina", "given": "Aleksandra", "initials": "A"}, {"family": "Mourtos", "given": "Evangelos", "initials": "E"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Segelsj\u00f6", "given": "Monica", "initials": "M"}, {"family": "Hansen", "given": "Tomas", "initials": "T"}, {"family": "Perchiazzi", "given": "Gaetano", "initials": "G", "orcid": "0000-0001-6834-6399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ef9ffc76bfe47c5afff104e9aaef020.json"}}], "type": "journal article", "published": "2021-08-04", "journal": {"title": "Crit Care", "issn": "1466-609X", "issn-l": "1364-8535", "volume": "25", "issue": "1", "pages": "276"}, "abstract": "Typical features differentiate COVID-19-associated lung injury from acute respiratory distress syndrome. The clinical role of chest computed tomography (CT) in describing the progression of COVID-19-associated lung injury remains to be clarified. We investigated in COVID-19 patients the regional distribution of lung injury and the influence of clinical and laboratory features on its progression.\n\nThis was a prospective study. For each CT, twenty images, evenly spaced along the cranio-caudal axis, were selected. For regional analysis, each CT image was divided into three concentric subpleural regions of interest and four quadrants. Hyper-, normally, hypo- and non-inflated lung compartments were defined. Nonparametric tests were used for hypothesis testing (\u03b1 = 0.05). Spearman correlation test was used to detect correlations between lung compartments and clinical features.\n\nTwenty-three out of 111 recruited patients were eligible for further analysis. Five hundred-sixty CT images were analyzed. Lung injury, composed by hypo- and non-inflated areas, was significantly more represented in subpleural than in core lung regions. A secondary, centripetal spread of lung injury was associated with exposure to mechanical ventilation (p < 0.04), longer spontaneous breathing (more than 14 days, p < 0.05) and non-protective tidal volume (p < 0.04). Positive fluid balance (p < 0.01), high plasma D-dimers (p < 0.01) and ferritin (p < 0.04) were associated with increased lung injury.\n\nIn a cohort of COVID-19 patients with severe respiratory failure, a predominant subpleural distribution of lung injury is observed. Prolonged spontaneous breathing and high tidal volumes, both causes of patient self-induced lung injury, are associated to an extensive involvement of more central regions. Positive fluid balance, inflammation and thrombosis are associated with lung injury. Trial registration Study registered a priori the 20th of March, 2020. Clinical Trials ID NCT04316884.", "doi": "10.1186/s13054-021-03685-4", "pmid": "34348797", "labels": {"Funder: VR": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Type: Journal article": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC8334337"}, {"db": "pii", "key": "10.1186/s13054-021-03685-4"}, {"db": "ClinicalTrials.gov", "key": "NCT04316884"}], "notes": [], "created": "2021-08-06T09:37:31.364Z", "modified": "2023-06-19T15:20:10.287Z"}, {"entity": "publication", "iuid": "f663618c9d864a089fdda6d5102066c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f663618c9d864a089fdda6d5102066c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f663618c9d864a089fdda6d5102066c9"}}, "title": "Update on: high but slightly declining COVID-19 vaccine acceptance and reasons for vaccine acceptance, Finland April to December 2020.", "authors": [{"family": "Hammer", "given": "Charlotte C", "initials": "CC", "orcid": "0000-0002-8288-0288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d188cd00689408ba9d6e336ed590f00.json"}}, {"family": "Cristea", "given": "Veronica", "initials": "V"}, {"family": "Dub", "given": "Timothee", "initials": "T", "orcid": "0000-0002-1819-518X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/034bb5fac60841c180b6a12101d5f4f0.json"}}, {"family": "Sivel\u00e4", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2021-08-03", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "issn-l": null, "volume": "149", "issue": null, "pages": "e187"}, "abstract": "We update our previous insights into COVID-19 vaccine acceptance and hesitancy in Finland. Vaccine acceptance increased from 64% (November/December 2020) to 74% (April 2021). However, there was a group of participants that were preferring to wait to get vaccinated ranging from 6% of over-64-years-olds to 29% of under-30-years-olds. The previously identified enablers convenience (below-50-years-olds), worry about severe disease and protection for oneself (above-50-years-olds) were no longer significantly associated with increased vaccine acceptance. Understanding barriers and enablers behind vaccine acceptance is decisive in ensuring a successful implementation of COVID-19 vaccination programs, which will be key to ending the pandemic.", "doi": "10.1017/S0950268821001680", "pmid": "34340722", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0950268821001680"}, {"db": "pmc", "key": "PMC8367874"}], "notes": [], "created": "2021-08-04T10:09:49.065Z", "modified": "2021-11-18T13:12:31.967Z"}, {"entity": "publication", "iuid": "44faeeb61bf343ae8acc034596145407", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44faeeb61bf343ae8acc034596145407.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44faeeb61bf343ae8acc034596145407"}}, "title": "Publisher Correction: Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice.", "authors": [{"family": "De Gasparo", "given": "Raoul", "initials": "R"}, {"family": "Pedotti", "given": "Mattia", "initials": "M"}, {"family": "Simonelli", "given": "Luca", "initials": "L"}, {"family": "Nickl", "given": "Petr", "initials": "P", "orcid": "0000-0002-4289-0502", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd09e87cae524e40922a94720a978674.json"}}, {"family": "Muecksch", "given": "Frauke", "initials": "F", "orcid": "0000-0002-0132-5101", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94b175929ad14fec921e737bb3dceda7.json"}}, {"family": "Cassaniti", "given": "Irene", "initials": "I"}, {"family": "Percivalle", "given": "Elena", "initials": "E"}, {"family": "Lorenzi", "given": "Julio C C", "initials": "JCC"}, {"family": "Mazzola", "given": "Federica", "initials": "F"}, {"family": "Magr\u00ec", "given": "Davide", "initials": "D", "orcid": "0000-0003-3790-5332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15cedaba7cb3438fad6c71e2a015921e.json"}}, {"family": "Michalcikova", "given": "Tereza", "initials": "T"}, {"family": "Haviernik", "given": "Jan", "initials": "J"}, {"family": "Honig", "given": "Vaclav", "initials": "V", "orcid": "0000-0003-0469-4604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65499eafa5a24320b87d2534f4dcf99a.json"}}, {"family": "Mrazkova", "given": "Blanka", "initials": "B"}, {"family": "Polakova", "given": "Natalie", "initials": "N"}, {"family": "Fortova", "given": "Andrea", "initials": "A"}, {"family": "Tureckova", "given": "Jolana", "initials": "J"}, {"family": "Iatsiuk", "given": "Veronika", "initials": "V"}, {"family": "Di Girolamo", "given": "Salvatore", "initials": "S"}, {"family": "Palus", "given": "Martin", "initials": "M"}, {"family": "Zudova", "given": "Dagmar", "initials": "D"}, {"family": "Bednar", "given": "Petr", "initials": "P"}, {"family": "Bukova", "given": "Ivana", "initials": "I"}, {"family": "Bianchini", "given": "Filippo", "initials": "F"}, {"family": "Mehn", "given": "Dora", "initials": "D"}, {"family": "Nencka", "given": "Radim", "initials": "R"}, {"family": "Strakova", "given": "Petra", "initials": "P"}, {"family": "Pavlis", "given": "Oto", "initials": "O"}, {"family": "Rozman", "given": "Jan", "initials": "J", "orcid": "0000-0002-8035-8904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69dca82b58b8449c8af3e096813d6003.json"}}, {"family": "Gioria", "given": "Sabrina", "initials": "S"}, {"family": "Sammartino", "given": "Jos\u00e8 Camilla", "initials": "JC"}, {"family": "Giardina", "given": "Federica", "initials": "F"}, {"family": "Gaiarsa", "given": "Stefano", "initials": "S"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q", "orcid": "0000-0003-1990-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94a32366862b470eba3a15521b9be290.json"}}, {"family": "Barnes", "given": "Christopher O", "initials": "CO"}, {"family": "Bjorkman", "given": "Pamela J", "initials": "PJ", "orcid": "0000-0002-2277-3990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65549e18865046ac99cfee9f969c2759.json"}}, {"family": "Calzolai", "given": "Luigi", "initials": "L", "orcid": "0000-0002-8474-7974", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e3a67661994a48e28a8279fb27346285.json"}}, {"family": "Piralla", "given": "Antonio", "initials": "A", "orcid": "0000-0002-6062-2579", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af56fb1bc11f43d9861faa71c5b50043.json"}}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Nussenzweig", "given": "Michel C", "initials": "MC"}, {"family": "Bieniasz", "given": "Paul D", "initials": "PD", "orcid": "0000-0002-2368-3719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72f7075120214d4091202cd80ffbe506.json"}}, {"family": "Hatziioannou", "given": "Theodora", "initials": "T"}, {"family": "Prochazka", "given": "Jan", "initials": "J"}, {"family": "Sedlacek", "given": "Radislav", "initials": "R", "orcid": "0000-0002-3352-392X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a1594084f604610a995def1f7a6bdb2.json"}}, {"family": "Robbiani", "given": "Davide F", "initials": "DF", "orcid": "0000-0001-7379-3484", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/941e237779f74a568228c6fe1ee8800c.json"}}, {"family": "Ruzek", "given": "Daniel", "initials": "D", "orcid": "0000-0003-4655-2380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f49c5724719433ea99ebf38a4ff4a58.json"}}, {"family": "Varani", "given": "Luca", "initials": "L", "orcid": "0000-0002-0963-0987", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6c4a4cecfc04659b3b8df2b49430ba6.json"}}], "type": "published erratum", "published": "2021-08-03", "journal": {"title": "Nature", "issn": "1476-4687", "issn-l": "0028-0836"}, "abstract": null, "doi": "10.1038/s41586-021-03719-5", "pmid": "34345019", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41586-021-03719-5"}], "notes": [], "created": "2021-08-06T09:46:27.837Z", "modified": "2021-08-06T09:46:31.466Z"}, {"entity": "publication", "iuid": "49c5fcdae47f44838b85c4eafba0ec1c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49c5fcdae47f44838b85c4eafba0ec1c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49c5fcdae47f44838b85c4eafba0ec1c"}}, "title": "Prevalence and determinants of serum antibodies to SARS-CoV-2 in the general population of the Gardena valley.", "authors": [{"family": "Melotti", "given": "Roberto", "initials": "R", "orcid": "0000-0003-4115-317X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9aadc5f020e74449a6ad0f6b87c55ec1.json"}}, {"family": "Scaggiante", "given": "Federica", "initials": "F"}, {"family": "Falciani", "given": "Michela", "initials": "M"}, {"family": "Weichenberger", "given": "Christian X", "initials": "CX"}, {"family": "Foco", "given": "Luisa", "initials": "L"}, {"family": "Lombardo", "given": "Stefano", "initials": "S"}, {"family": "De Grandi", "given": "Alessandro", "initials": "A"}, {"family": "von Laer", "given": "Dorothee", "initials": "D"}, {"family": "Mahlknecht", "given": "Angelika", "initials": "A"}, {"family": "Pramstaller", "given": "Peter P", "initials": "PP"}, {"family": "Pagani", "given": "Elisabetta", "initials": "E", "orcid": "0000-0002-4008-6756", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1161d621cf434cb8a7a245e40f2fc90f.json"}}, {"family": "Meier", "given": "Horand", "initials": "H"}, {"family": "Gaertner", "given": "Timon", "initials": "T"}, {"family": "Troi", "given": "Christina", "initials": "C"}, {"family": "Mascalzoni", "given": "Deborah", "initials": "D"}, {"family": "Pattaro", "given": "Cristian", "initials": "C"}, {"family": "Mian", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2021-08-03", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": "149", "pages": "e194", "issn-l": null}, "abstract": "Estimating the spread of SARS-CoV-2 infection in communities is critical. We surveyed 2244 stratified random sample community members of the Gardena valley, a winter touristic area, amidst the first expansion phase of the COVID-19 pandemic in Europe. We measured agreement between Diasorin and Abbott serum bioassay outputs and the Abbott optimal discriminant threshold of serum neutralisation titres with recursive receiver operating characteristic curve. We analytically adjusted serum antibody tests for unbiased seroprevalence estimate and analysed the determinants of infection with non-response weighted multiple logistic regression. SARS-CoV-2 seroprevalence was 26.9% (95% CI 25.2-28.6) by June 2020. The bioassays had a modest agreement with each other. At a lower threshold than the manufacturer's recommended level, the Abbott assay reflected greater discrimination of serum neutralisation capacity. Seropositivity was associated with place and economic activity, not with sex or age. Symptoms like fever and weakness were age-dependent. SARS-CoV-2 mitigation strategies should account for context in high prevalence areas.", "doi": "10.1017/S0950268821001886", "pmid": "34645534", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0950268821001886"}, {"db": "pmc", "key": "PMC8387688"}], "notes": [], "created": "2021-10-21T05:07:20.223Z", "modified": "2021-10-21T05:07:20.314Z"}, {"entity": "publication", "iuid": "5b8ec62501cf41da8f6c8fdc9837a030", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5b8ec62501cf41da8f6c8fdc9837a030.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5b8ec62501cf41da8f6c8fdc9837a030"}}, "title": "Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients.", "authors": [{"family": "Huckriede", "given": "Joram", "initials": "J"}, {"family": "Anderberg", "given": "Sara B\u00fclow", "initials": "SB"}, {"family": "Morales", "given": "Albert", "initials": "A"}, {"family": "de Vries", "given": "Femke", "initials": "F"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Bergqvist", "given": "Anders", "initials": "A"}, {"family": "Ortiz-P\u00e9rez", "given": "Jos\u00e9 T", "initials": "JT"}, {"family": "Sels", "given": "Jan Willem", "initials": "JW"}, {"family": "Wichapong", "given": "Kanin", "initials": "K"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "van de Poll", "given": "Marcel", "initials": "M"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Luther", "given": "Tomas", "initials": "T"}, {"family": "Reutelingsperger", "given": "Chris", "initials": "C"}, {"family": "de Frutos", "given": "Pablo Garcia", "initials": "PG"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Nicolaes", "given": "Gerry A F", "initials": "GAF"}], "type": "journal article", "published": "2021-08-03", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "15701"}, "abstract": "Coronavirus disease 19 (COVID-19) presents with disease severities of varying degree. In its most severe form, infection may lead to respiratory failure and multi-organ dysfunction. Here we study the levels and evolution of the damage associated molecular patterns (DAMPS) cell free DNA (cfDNA), extracellular histone H3 (H3) and neutrophil elastase (NE), and the immune modulators GAS6 and AXL in relation to clinical parameters, ICU scoring systems and mortality in patients (n = 100) with severe COVID-19. cfDNA, H3, NE, GAS6 and AXL were increased in COVID-19 patients compared to controls. These measures associated with occurrence of clinical events and intensive care unit acquired weakness (ICUAW). cfDNA and GAS6 decreased in time in patients surviving to 30 days post ICU admission. A decrease of 27.2 ng/mL cfDNA during ICU stay associated with patient survival, whereas levels of GAS6 decreasing more than 4.0 ng/mL associated with survival. The presence of H3 in plasma was a common feature of COVID-19 patients, detected in 38% of the patients at ICU admission. NETosis markers cfDNA, H3 and NE correlated well with parameters of tissue damage and neutrophil counts. Furthermore, cfDNA correlated with lowest p/f ratio and a lowering in cfDNA was observed in patients with ventilator-free days.", "doi": "10.1038/s41598-021-95209-x", "pmid": "34344929", "labels": {"Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-95209-x"}], "notes": [], "created": "2021-01-04T09:26:11.519Z", "modified": "2021-08-06T09:49:20.947Z"}, {"entity": "publication", "iuid": "91448b51a4264a738436edb06b9f2b23", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/91448b51a4264a738436edb06b9f2b23.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/91448b51a4264a738436edb06b9f2b23"}}, "title": "Persisting Salivary IgG Against SARS-CoV-2 at 9 Months After Mild COVID-19: A Complementary Approach to Population Surveys.", "authors": [{"family": "Alkharaan", "given": "Hassan", "initials": "H"}, {"family": "Bayati", "given": "Shaghayegh", "initials": "S"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Olsson", "given": "Annika", "initials": "A"}, {"family": "Lindahl", "given": "Karin", "initials": "K"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "Tsilingaridis", "given": "Georgios", "initials": "G"}, {"family": "De Palma", "given": "Patricia", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M", "orcid": "0000-0002-3793-4064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4bc179656eb442f9ac9dc72c8c6841d.json"}}], "type": "journal article", "published": "2021-08-02", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899", "volume": "224", "issue": "3", "pages": "407-414"}, "abstract": "Declining humoral immunity in coronavirus disease 2019 (COVID-19) patients and possible reinfection have raised concern. Mucosal immunity, particularly salivary antibodies, may be short lived although long-term studies are lacking.\r\n\r\nUsing a multiplex bead-based array platform, we investigated antibodies specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins in 256 saliva samples from convalescent patients 1-9 months after symptomatic COVID-19 (n = 74, cohort 1), undiagnosed individuals with self-reported questionnaires (n = 147, cohort 2), and individuals sampled prepandemic (n = 35, cohort 3).\r\n\r\nSalivary IgG antibody responses in cohort 1 (mainly mild COVID-19) were detectable up to 9 months postrecovery, with high correlations between spike and nucleocapsid specificity. At 9 months, IgG remained in blood and saliva in most patients. Salivary IgA was rarely detected at this time point. In cohort 2, salivary IgG and IgA responses were significantly associated with recent history of COVID-19-like symptoms. Salivary IgG tolerated temperature and detergent pretreatments.\r\n\r\nUnlike SARS-CoV-2 salivary IgA that appeared short lived, specific saliva IgG appeared stable even after mild COVID-19, as for blood serology. This noninvasive saliva-based SARS-CoV-2 antibody test with home self-collection may be a complementary alternative to conventional blood serology.", "doi": "10.1093/infdis/jiab256", "pmid": "33978762", "labels": {"Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: High-throughput and high-content serology": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "6274637"}, {"db": "pmc", "key": "PMC8244549"}], "notes": [], "created": "2021-05-17T18:21:49.460Z", "modified": "2021-11-18T15:58:51.138Z"}, {"entity": "publication", "iuid": "dfb5199537e741fdbd4383c7cea19f7c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dfb5199537e741fdbd4383c7cea19f7c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dfb5199537e741fdbd4383c7cea19f7c"}}, "title": "Correlates of intended COVID-19 vaccine acceptance across time and countries: results from a series of cross-sectional surveys.", "authors": [{"family": "Kerr", "given": "John R", "initials": "JR", "orcid": "0000-0002-6606-5507", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7189181d83744a68a99673f7d3a1c28c.json"}}, {"family": "Schneider", "given": "Claudia R", "initials": "CR", "orcid": "0000-0002-6612-5186", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6bbf77e665d4610b7bfe907bc934e9f.json"}}, {"family": "Recchia", "given": "Gabriel", "initials": "G", "orcid": "0000-0002-0210-8635", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e373f0f611e14509b26b643e736506ce.json"}}, {"family": "Dryhurst", "given": "Sarah", "initials": "S", "orcid": "0000-0002-7772-8492", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27179dd2c377475eb5aff23c270ebae4.json"}}, {"family": "Sahlin", "given": "Ullrika", "initials": "U", "orcid": "0000-0002-2932-6253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5af5b2eef6ab49dc8e91d3b41a973242.json"}}, {"family": "Dufouil", "given": "Carole", "initials": "C", "orcid": "0000-0003-2442-4476", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd796b2a505c4549a60d215286f851e0.json"}}, {"family": "Arwidson", "given": "Pierre", "initials": "P"}, {"family": "Freeman", "given": "Alexandra Lj", "initials": "AL", "orcid": "0000-0002-4115-161X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/746c0638712541e78b89fca05787da4e.json"}}, {"family": "van der Linden", "given": "Sander", "initials": "S", "orcid": "0000-0002-0269-1744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e54f2d24c11437d8b032ffab9b6909e.json"}}], "type": "journal article", "published": "2021-08-02", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "8", "pages": "e048025"}, "abstract": "Describe demographical, social and psychological correlates of willingness to receive a COVID-19 vaccine.\r\n\r\nSeries of online surveys undertaken between March and October 2020.\r\n\r\nA total of 25 separate national samples (matched to country population by age and sex) in 12 different countries were recruited through online panel providers (n=25 334).\r\n\r\nReported willingness to receive a COVID-19 vaccination.\r\n\r\nReported willingness to receive a vaccine varied widely across samples, ranging from 63% to 88%. Multivariate logistic regression analyses reveal sex (female OR=0.59, 95% CI 0.55 to 0.64), trust in medical and scientific experts (OR=1.28, 95% CI 1.22 to 1.34) and worry about the COVID-19 virus (OR=1.47, 95% CI 1.41 to 1.53) as the strongest correlates of stated vaccine acceptance considering pooled data and the most consistent correlates across countries. In a subset of UK samples, we show that these effects are robust after controlling for attitudes towards vaccination in general.\r\n\r\nOur results indicate that the burden of trust largely rests on the shoulders of the scientific and medical community, with implications for how future COVID-19 vaccination information should be communicated to maximise uptake.", "doi": "10.1136/bmjopen-2020-048025", "pmid": "34341047", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-048025"}, {"db": "URL", "key": "https://osf.io/p3fau/", "description": "Vaccine data"}, {"db": "URL", "key": "https://osf.io/wdjqx/", "description": "First case and first death per country"}], "notes": [], "created": "2021-08-04T10:09:21.889Z", "modified": "2021-11-19T11:24:29.832Z"}, {"entity": "publication", "iuid": "223875a4ae8849d1acaa4e0e4e94cafb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/223875a4ae8849d1acaa4e0e4e94cafb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/223875a4ae8849d1acaa4e0e4e94cafb"}}, "title": "Clinical characteristics and factors associated with COVID-19-related death and morbidity among hospitalized patients with cancer: a Swedish cohort study.", "authors": [{"family": "Ullgren", "given": "Helena", "initials": "H", "orcid": "0000-0001-5747-853X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8778c04e9c5a45a480e31c662d6b3459.json"}}, {"family": "Camuto", "given": "Angela", "initials": "A"}, {"family": "Rosas", "given": "Sumy", "initials": "S"}, {"family": "Pahnke", "given": "Simon", "initials": "S", "orcid": "0000-0002-3541-2027", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f7056035dab4a0080d35b40977463a8.json"}}, {"family": "Ginman", "given": "Beatrice", "initials": "B"}, {"family": "Enblad", "given": "Gunilla", "initials": "G", "orcid": "0000-0002-0594-724X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06a5b2ff78ac42c79e867240bbc11038.json"}}, {"family": "Glimelius", "given": "Ingrid", "initials": "I"}, {"family": "Fransson", "given": "Per", "initials": "P"}, {"family": "Friesland", "given": "Signe", "initials": "S"}, {"family": "Liu", "given": "Lisa", "initials": "L"}], "type": "journal article", "published": "2021-08-02", "journal": {"title": "Acta Oncol", "issn": "1651-226X", "pages": "1-7", "issn-l": null}, "abstract": "Cancer patients are considered to have a higher risk of dying and developing severe Coronavirus Disease 2019 (COVID-19). To date, there are few studies including co-morbidities and sociodemographic factors when investigating the outcome of COVID-19 in a cohort of cancer patients. In this study, we analyzed cancer patients that have been hospitalized due to COVID-19 during the first wave of the pandemic in Sweden to investigate the impact of COVID-19 on mortality and morbidity.\n\nWe retrospectively collected data on all patients with cancer that were hospitalized due to COVID-19-related symptoms at Uppsala University Hospital and Karolinska University Hospital between 1 March and 31 August 2020. The primary endpoint was COVID-19-related death and the secondary endpoint was to describe COVID-19 severity, defined as symptom severity (grades 0-4) and length of stay (LOS) at the university hospitals.\n\nIn total, 193 patients were included among which 31% died due to COVID-19 and 8% died of other causes. In a multivariable analysis, older age >70 (OR 3.6; 95% CI [1.8-7.3], p < 0.001) and male gender (OR 2.8 [1.4-5.8], p = 0.005) were factors associated with higher likelihood of COVID-19-related death. Several comorbidities \u22652 (OR 5.4 [2.0-14.3], p = 0.001) was independently associated with COVID-19 severity. Treatment with chemotherapy within 90 days prior to COVID-19 diagnosis were not associated with COVID-19-related death or severity.\n\nFactors associated with higher likelihood of COVID-19-related death were older age and male gender. More severe COVID-19 symptoms were seen in patients with multiple comorbidities. We did not see any associations between COVID-19-related death or severity and recent treatment including chemotherapy. In summary, this supports a thorough assessment regarding potential risks with COVID-19 infection in patients with cancer, with a combination of individual risk factors in addition to cancer treatments.", "doi": "10.1080/0284186X.2021.1958005", "pmid": "34334081", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-08-04T10:13:59.528Z", "modified": "2021-08-04T17:02:06.248Z"}, {"entity": "publication", "iuid": "0e0e178f9c3c43bea277a58e46ce4e94", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e0e178f9c3c43bea277a58e46ce4e94.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e0e178f9c3c43bea277a58e46ce4e94"}}, "title": "A phenomics approach for antiviral drug discovery.", "authors": [{"family": "Rietdijk", "given": "Jonne", "initials": "J"}, {"family": "Tampere", "given": "Marianna", "initials": "M"}, {"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Georgiev", "given": "Polina", "initials": "P"}, {"family": "Lapins", "given": "Maris", "initials": "M"}, {"family": "Warpman-Berglund", "given": "Ulrika", "initials": "U"}, {"family": "Spjuth", "given": "Ola", "initials": "O"}, {"family": "Puumalainen", "given": "Marjo-Riitta", "initials": "MR"}, {"family": "Carreras-Puigvert", "given": "Jordi", "initials": "J", "orcid": "0000-0002-7671-3707", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1fc481c38384cf78f24a490ec562e9a.json"}}], "type": "journal article", "published": "2021-08-02", "journal": {"title": "BMC Biol", "issn": "1741-7007", "issn-l": null, "volume": "19", "issue": "1", "pages": "156"}, "abstract": "The emergence and continued global spread of the current COVID-19 pandemic has highlighted the need for methods to identify novel or repurposed therapeutic drugs in a fast and effective way. Despite the availability of methods for the discovery of antiviral drugs, the majority tend to focus on the effects of such drugs on a given virus, its constituent proteins, or enzymatic activity, often neglecting the consequences on host cells. This may lead to partial assessment of the efficacy of the tested anti-viral compounds, as potential toxicity impacting the overall physiology of host cells may mask the effects of both viral infection and drug candidates. Here we present a method able to assess the general health of host cells based on morphological profiling, for untargeted phenotypic drug screening against viral infections.\n\nWe combine Cell Painting with antibody-based detection of viral infection in a single assay. We designed an image analysis pipeline for segmentation and classification of virus-infected and non-infected cells, followed by extraction of morphological properties. We show that this methodology can successfully capture virus-induced phenotypic signatures of MRC-5 human lung fibroblasts infected with human coronavirus 229E (CoV-229E). Moreover, we demonstrate that our method can be used in phenotypic drug screening using a panel of nine host- and virus-targeting antivirals. Treatment with effective antiviral compounds reversed the morphological profile of the host cells towards a non-infected state.\n\nThe phenomics approach presented here, which makes use of a modified Cell Painting protocol by incorporating an anti-virus antibody stain, can be used for the unbiased morphological profiling of virus infection on host cells. The method can identify antiviral reference compounds, as well as novel antivirals, demonstrating its suitability to be implemented as a strategy for antiviral drug repurposing and drug discovery.", "doi": "10.1186/s12915-021-01086-1", "pmid": "34334126", "labels": {"Funder: KAW/SciLifeLab": null, "Research Area: Drug discovery and repurposing of drugs": null, "Funder: VR": null, "Funder: H2020": null, "Category: Biochemistry": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8325993"}, {"db": "pii", "key": "10.1186/s12915-021-01086-1"}], "notes": [], "created": "2021-01-15T14:22:24.952Z", "modified": "2023-06-19T14:38:06.897Z"}, {"entity": "publication", "iuid": "eab92d11331949bda69a729bffc89d35", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eab92d11331949bda69a729bffc89d35.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eab92d11331949bda69a729bffc89d35"}}, "title": "Whether, when and how to extend unemployment benefits: Theory and application to COVID-19.", "authors": [{"family": "Mitman", "given": "Kurt", "initials": "K"}, {"family": "Rabinovich", "given": "Stanislav", "initials": "S"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "J Public Econ", "issn": "0047-2727", "issn-l": null, "volume": "200", "issue": null, "pages": "104447"}, "abstract": "We investigate the optimal response of unemployment insurance to economic shocks, both with and without commitment. The optimal policy with commitment follows a modified Baily-Chetty formula that accounts for job search responses to future UI benefit changes. As a result, the optimal policy with commitment tends to front-load UI, unlike the optimal discretionary policy. In response to shocks intended to mimic those that induced the COVID-19 recession, we find that a large and transitory increase in UI is optimal; and that a policy rule contingent on the change in unemployment, rather than its level, is a good approximation to the optimal policy.", "doi": "10.1016/j.jpubeco.2021.104447", "pmid": "34934254", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0047-2727(21)00083-9"}, {"db": "pmc", "key": "PMC8677353"}], "notes": [], "created": "2022-01-03T15:31:55.461Z", "modified": "2022-11-23T08:54:16.211Z"}, {"entity": "publication", "iuid": "3691196ee38a4d3986720e18d83fe719", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3691196ee38a4d3986720e18d83fe719.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3691196ee38a4d3986720e18d83fe719"}}, "title": "Towards a European strategy to address the COVID-19 pandemic", "authors": [{"family": "Priesemann", "given": "Viola", "initials": "V"}, {"family": "Balling", "given": "Rudi", "initials": "R"}, {"family": "Bauer", "given": "Simon", "initials": "S"}, {"family": "Beutels", "given": "Philippe", "initials": "P"}, {"family": "Valdez", "given": "Andr\u00e9 Calero", "initials": "AC"}, {"family": "Cuschieri", "given": "Sarah", "initials": "S"}, {"family": "Czypionka", "given": "Thomas", "initials": "T"}, {"family": "Dumpis", "given": "Uga", "initials": "U"}, {"family": "Glaab", "given": "Enrico", "initials": "E"}, {"family": "Grill", "given": "Eva", "initials": "E"}, {"family": "Hotulainen", "given": "Pirta", "initials": "P"}, {"family": "Iftekhar", "given": "Emil N", "initials": "EN"}, {"family": "Krutzinna", "given": "Jenny", "initials": "J"}, {"family": "Lionis", "given": "Christos", "initials": "C"}, {"family": "Machado", "given": "Helena", "initials": "H"}, {"family": "Martins", "given": "Carlos", "initials": "C"}, {"family": "McKee", "given": "Martin", "initials": "M"}, {"family": "Pavlakis", "given": "George N", "initials": "GN"}, {"family": "Perc", "given": "Matja\u017e", "initials": "M"}, {"family": "Petelos", "given": "Elena", "initials": "E"}, {"family": "Pickersgill", "given": "Martyn", "initials": "M"}, {"family": "Prainsack", "given": "Barbara", "initials": "B"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}, {"family": "Schernhammer", "given": "Eva", "initials": "E"}, {"family": "Szczurek", "given": "Ewa", "initials": "E"}, {"family": "Tsiodras", "given": "Sotirios", "initials": "S"}, {"family": "Van Gucht", "given": "Steven", "initials": "S"}, {"family": "Willeit", "given": "Peter", "initials": "P"}], "type": "journal-article", "published": "2021-08-00", "journal": {"title": "Lancet", "issn": "0140-6736", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/s0140-6736(21)01808-0", "pmid": null, "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-08-13T12:00:52.537Z", "modified": "2021-08-13T12:01:45.972Z"}, {"entity": "publication", "iuid": "cc82cb507a2a48c2a09b29e2c13b6cce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc82cb507a2a48c2a09b29e2c13b6cce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc82cb507a2a48c2a09b29e2c13b6cce"}}, "title": "The COVID-19 pandemic first wave in Sweden: A national registry study of the effects on pediatric anesthesia and surgery.", "authors": [{"family": "Melander", "given": "Sixten", "initials": "S"}, {"family": "Almstr\u00f6m", "given": "Jimmy", "initials": "J"}, {"family": "Enlund", "given": "Gunnar", "initials": "G", "orcid": "0000-0001-9438-3644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf636f1ef6744d0cbc4008ac4eb2e216.json"}}, {"family": "Frykholm", "given": "Peter", "initials": "P", "orcid": "0000-0001-6402-136X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/674a3d5efa544036a4b46bb6608ea28d.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Paediatr Anaesth", "issn": "1460-9592", "volume": "31", "issue": "8", "pages": "846-853", "issn-l": null}, "abstract": "The COVID-19 pandemic is pushing healthcare systems to their limits. Dramatic reductions in the adult elective surgery are ubiquitous, but corresponding changes in pediatric services are not well described. The Swedish Perioperative Registry contains data on all anesthetic procedures in Sweden, and therefore, provides a unique opportunity to analyze the effect of the pandemic on the pediatric anesthesia capacity on a national level. We hypothesized that there would be a significant reduction in pediatric elective procedures. The aim was to determine the effects on pediatric surgical and anesthetic services during the first wave of the COVID-19 pandemic in Sweden.\n\nFor this retrospective registry cohort study, we extracted all procedures performed on patients <18 years of age in 2020 and 2019. Weeks 12 to 26 of 2020 were defined as the first wave, and data were analyzed according to level of care, type of surgery, procedure code, and emergency or elective surgery.\n\nWe found 7015 fewer procedures during the first wave epoch. Elective cases were reduced by 53.7% while emergency surgery was not significantly affected. During the peak of the first wave in April, there was a 72.8% reduction in elective cases; ENT/maxillofacial surgery showed the greatest reduction (86.7%). The surgical and anesthesia capacity recovered to near-normal levels by the end of June 2020.\n\nWe conclude that the impact of COVID-19 on pediatric surgical procedures in Sweden during the first wave of the pandemic was dramatic, but elective services were restored a few months after the peak.", "doi": "10.1111/pan.14203", "pmid": "33971054", "labels": {"Type: Journal article": null, "Category: Health": null, "Topics: Register-based research": null}, "xrefs": [{"db": "pmc", "key": "PMC8242453"}], "notes": [], "created": "2021-05-17T19:02:06.933Z", "modified": "2023-01-13T13:41:44.243Z"}, {"entity": "publication", "iuid": "dbeff85cff3047e0849558961640bf69", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dbeff85cff3047e0849558961640bf69.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dbeff85cff3047e0849558961640bf69"}}, "title": "Significant variations across European centres in implementing recommended guidelines for the paediatric gastroenterology endoscopy suite during the COVID-19 pandemic.", "authors": [{"family": "Athiana", "given": "Ilektra", "initials": "I"}, {"family": "L\u00e9geret", "given": "Corinne", "initials": "C"}, {"family": "Bontems", "given": "Patrick", "initials": "P"}, {"family": "Dall'Oglio", "given": "Luigi", "initials": "L"}, {"family": "De Angelis", "given": "Paola", "initials": "P"}, {"family": "Dias", "given": "Jorge Amil", "initials": "JA"}, {"family": "Hauser", "given": "Bruno", "initials": "B"}, {"family": "Homan", "given": "Matja\u017e", "initials": "M"}, {"family": "Narula", "given": "Priya", "initials": "P"}, {"family": "Norsa", "given": "Lorenzo", "initials": "L"}, {"family": "Oliva", "given": "Salvatore", "initials": "S"}, {"family": "Papadopoulou", "given": "Alexandra", "initials": "A"}, {"family": "Romano", "given": "Claudio", "initials": "C"}, {"family": "Thomson", "given": "Mike", "initials": "M"}, {"family": "Vila-Miravet", "given": "Victor", "initials": "V"}, {"family": "Furlano", "given": "Raoul I", "initials": "RI"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "JPGN Rep", "issn": "2691-171X", "volume": "2", "issue": "3", "pages": "e061", "issn-l": null}, "abstract": "The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) published recommendations regarding protection for the paediatric endoscopist during the coronavirus 2019 (COVID-19) pandemic.The aim of this survey was to investigate whether European paediatric gastroenterology centres applied the recommendations and how this extraordinary situation was handled by the different centres.\n\nTwelve paediatric European gastroenterology centres participated. Nine centres (75%) screened their patients for possible COVID-19 infection before the procedure, the same amount of hospitals changed their practice based on the ESPGHAN recommendations. Six-seven percentage of the centres reduced the staff in the endoscopy suite, 83% of the units used FFP2/3 masks and protective goggles during the procedure and 75% wore waterproof gowns.\n\nUniform guidelines could not be applied by all European hospitals at a certain time point of the viral spread, as different regions of Europe were not only affected differently by COVID-19, but also had different access to personal protective equipment.", "doi": "10.1097/PG9.0000000000000061", "pmid": "34192294", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8162040"}], "notes": [], "created": "2021-07-05T14:27:51.312Z", "modified": "2021-07-05T14:27:51.336Z"}, {"entity": "publication", "iuid": "8caa88f775e948a4bf6725d86b5850f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8caa88f775e948a4bf6725d86b5850f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8caa88f775e948a4bf6725d86b5850f2"}}, "title": "SARS-CoV-2 infections amongst personnel providing home care services for older persons in Stockholm, Sweden.", "authors": [{"family": "Hassan", "given": "S S", "initials": "SS"}, {"family": "Seigerud", "given": "\u00c5", "initials": "\u00c5"}, {"family": "Abdirahman", "given": "R", "initials": "R"}, {"family": "Arroyo M\u00fchr", "given": "L S", "initials": "LS"}, {"family": "Nordqvist Kleppe", "given": "S", "initials": "S"}, {"family": "Pin", "given": "E", "initials": "E"}, {"family": "M\u00e5nberg", "given": "A", "initials": "A"}, {"family": "Hober", "given": "S", "initials": "S"}, {"family": "Nilsson", "given": "P", "initials": "P"}, {"family": "Engstrand", "given": "L", "initials": "L"}, {"family": "Miriam Elfstr\u00f6m", "given": "K", "initials": "K"}, {"family": "Blomqvist", "given": "J", "initials": "J"}, {"family": "Conneryd Lundgren", "given": "K", "initials": "K"}, {"family": "Dillner", "given": "J", "initials": "J", "orcid": "0000-0001-8588-6506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bbb8b0ca5dc648e0b80c1de224b26c69.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": "290", "issue": "2", "pages": "430-436"}, "abstract": "In Sweden, home care services is a major external contact for older persons.\n\nFive home care service companies in Stockholm, Sweden, enrolled 405 employees to a study including serum IgG to SARS-CoV-2 and SARS-CoV-2 virus in throat swabs.\n\n20.1% (81/403) of employees were seropositive, about twice as many as in a simultaneously enrolled reference population (healthcare workers entirely without patient contact, n = 3671; 9.7% seropositivity). 13/379 employees (3.4%) had a current infection (PCR positivity). Amongst these, 5 were also seropositive and 3 were positive with low amounts of virus. High amounts of virus and no antibodies (a characteristic for presymptomatic COVID-19) were present in 5 employees (1.3%).\n\nPersonnel providing home services for older persons appear to be a risk group for SARS-CoV-2. Likely presymptomatic employees can be readily identified by screening. Increased protection of employees and of the older persons they serve is warranted.", "doi": "10.1111/joim.13274", "pmid": "33843090", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Serology": null}, "xrefs": [{"db": "pmc", "key": "PMC8250663"}], "notes": [], "created": "2021-04-13T10:17:03.259Z", "modified": "2021-11-18T16:00:16.404Z"}, {"entity": "publication", "iuid": "7d609c06c1ab41a1bb9dbd6937403c84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d609c06c1ab41a1bb9dbd6937403c84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d609c06c1ab41a1bb9dbd6937403c84"}}, "title": "Risk factors for the delayed viral clearance in COVID-19 patients.", "authors": [{"family": "Chen", "given": "Xiaoping", "initials": "X"}, {"family": "Hu Mt", "given": "Wenjia", "initials": "W"}, {"family": "Yang", "given": "Miao", "initials": "M"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Zhang", "given": "Yongxi", "initials": "Y"}, {"family": "Deng", "given": "Liping", "initials": "L"}, {"family": "Li", "given": "Jinlin", "initials": "J"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Lindahl", "given": "Johanna F", "initials": "JF"}, {"family": "Xiong", "given": "Yong", "initials": "Y", "orcid": "0000-0003-0678-4064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37777ebb9bda45caa57a6c39ebd17ded.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "J Clin Hypertens (Greenwich)", "issn": "1751-7176", "issn-l": "1524-6175", "volume": "23", "issue": "8", "pages": "1483-1489"}, "abstract": "Comorbidities are important for the disease outcome of COVID-19, however, which underlying diseases that contribute the most to aggravate the conditions of COVID-19 patients are still unclear. Viral clearance is the most important laboratory test for defining the recovery of COVID-19 infections. To better understand which underlying diseases that are risk factors for delaying the viral clearance, we retrospectively analyzed 161 COVID-19 clinical cases in the Zhongnan Hospital of Wuhan University, Wuhan, China between January 5 and March 13, 2020. The demographic, clinical and laboratory data, as well as patient treatment records were collected. Univariable and multivariable analysis were performed to explore the association between delayed viral clearance and other factors by using logistic regression. Survival analyses by Kaplan-Meier and Cox regression modeling were employed to identify factors negatively influencing the viral clearance negatively. We found that hypertension and intravenous immunoglobulin adversely affected the time of viral RNA shedding. Hypertension was the most important risk factor to delay the SARS-CoV-2 virus clearance, however, the use of Angiotensin-Converting Enzyme Inhibitors(ACEI)/Angiotensin Receptor Blockers(ARB) did not shorten the time for virus clearance in these hypertensive patients' virus clearance. We conclude that patients having hypertension and intravenous immunoglobulin may delay the viral clearance in COVID-19 patients.", "doi": "10.1111/jch.14308", "pmid": "34171164", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8420571"}], "notes": [], "created": "2021-06-28T18:00:36.406Z", "modified": "2023-06-19T15:32:23.071Z"}, {"entity": "publication", "iuid": "d5aeef1eb51f47d7b04cd19fa4379b3c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5aeef1eb51f47d7b04cd19fa4379b3c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5aeef1eb51f47d7b04cd19fa4379b3c"}}, "title": "Rapid Exclusion of COVID Infection With the Artificial Intelligence Electrocardiogram.", "authors": [{"family": "Attia", "given": "Zachi I", "initials": "ZI"}, {"family": "Kapa", "given": "Suraj", "initials": "S"}, {"family": "Dugan", "given": "Jennifer", "initials": "J"}, {"family": "Pereira", "given": "Naveen", "initials": "N"}, {"family": "Noseworthy", "given": "Peter A", "initials": "PA"}, {"family": "Jimenez", "given": "Francisco Lopez", "initials": "FL"}, {"family": "Cruz", "given": "Jessica", "initials": "J"}, {"family": "Carter", "given": "Rickey E", "initials": "RE"}, {"family": "DeSimone", "given": "Daniel C", "initials": "DC"}, {"family": "Signorino", "given": "John", "initials": "J"}, {"family": "Halamka", "given": "John", "initials": "J"}, {"family": "Chennaiah Gari", "given": "Nikhita R", "initials": "NR"}, {"family": "Madathala", "given": "Raja Sekhar", "initials": "RS"}, {"family": "Platonov", "given": "Pyotr G", "initials": "PG"}, {"family": "Gul", "given": "Fahad", "initials": "F"}, {"family": "Janssens", "given": "Stefan P", "initials": "SP"}, {"family": "Narayan", "given": "Sanjiv", "initials": "S"}, {"family": "Upadhyay", "given": "Gaurav A", "initials": "GA"}, {"family": "Alenghat", "given": "Francis J", "initials": "FJ"}, {"family": "Lahiri", "given": "Marc K", "initials": "MK"}, {"family": "Dujardin", "given": "Karl", "initials": "K"}, {"family": "Hermel", "given": "Melody", "initials": "M"}, {"family": "Dominic", "given": "Paari", "initials": "P"}, {"family": "Turk-Adawi", "given": "Karam", "initials": "K"}, {"family": "Asaad", "given": "Nidal", "initials": "N"}, {"family": "Svensson", "given": "Anneli", "initials": "A"}, {"family": "Fernandez-Aviles", "given": "Francisco", "initials": "F"}, {"family": "Esakof", "given": "Darryl D", "initials": "DD"}, {"family": "Bartunek", "given": "Jozef", "initials": "J"}, {"family": "Noheria", "given": "Amit", "initials": "A"}, {"family": "Sridhar", "given": "Arun R", "initials": "AR"}, {"family": "Lanza", "given": "Gaetano A", "initials": "GA"}, {"family": "Cohoon", "given": "Kevin", "initials": "K"}, {"family": "Padmanabhan", "given": "Deepak", "initials": "D"}, {"family": "Pardo Gutierrez", "given": "Jose Alberto", "initials": "JA"}, {"family": "Sinagra", "given": "Gianfranco", "initials": "G"}, {"family": "Merlo", "given": "Marco", "initials": "M"}, {"family": "Zagari", "given": "Domenico", "initials": "D"}, {"family": "Rodriguez Escenaro", "given": "Brenda D", "initials": "BD"}, {"family": "Pahlajani", "given": "Dev B", "initials": "DB"}, {"family": "Loncar", "given": "Goran", "initials": "G"}, {"family": "Vukomanovic", "given": "Vladan", "initials": "V"}, {"family": "Jensen", "given": "Henrik K", "initials": "HK"}, {"family": "Farkouh", "given": "Michael E", "initials": "ME"}, {"family": "Luescher", "given": "Thomas F", "initials": "TF"}, {"family": "Su Ping", "given": "Carolyn Lam", "initials": "CL"}, {"family": "Peters", "given": "Nicholas S", "initials": "NS"}, {"family": "Friedman", "given": "Paul A", "initials": "PA"}, {"family": "Discover Consortium (Digital and Noninvasive Screening for COVID-19 with AI ECG Repository)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Mayo Clin Proc", "issn": "1942-5546", "volume": "96", "issue": "8", "pages": "2081-2094", "issn-l": "0025-6196"}, "abstract": "To rapidly exclude severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection using artificial intelligence applied to the electrocardiogram (ECG).\n\nA global, volunteer consortium from 4 continents identified patients with ECGs obtained around the time of polymerase chain reaction-confirmed COVID-19 diagnosis and age- and sex-matched controls from the same sites. Clinical characteristics, polymerase chain reaction results, and raw electrocardiographic data were collected. A convolutional neural network was trained using 26,153 ECGs (33.2% COVID positive), validated with 3826 ECGs (33.3% positive), and tested on 7870 ECGs not included in other sets (32.7% positive). Performance under different prevalence values was tested by adding control ECGs from a single high-volume site.\n\nThe area under the curve for detection of acute COVID-19 infection in the test group was 0.767 (95% CI, 0.756 to 0.778; sensitivity, 98%; specificity, 10%; positive predictive value, 37%; negative predictive value, 91%). To more accurately reflect a real-world population, 50,905 normal controls were added to adjust the COVID prevalence to approximately 5% (2657/58,555), resulting in an area under the curve of 0.780 (95% CI, 0.771 to 0.790) with a specificity of 12.1% and a negative predictive value of 99.2%.\n\nInfection with SARS-CoV-2 results in electrocardiographic changes that permit the artificial intelligence-enhanced ECG to be used as a rapid screening test with a high negative predictive value (99.2%). This may permit the development of electrocardiography-based tools to rapidly screen individuals for pandemic control.", "doi": "10.1016/j.mayocp.2021.05.027", "pmid": "34353468", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0025-6196(21)00469-9"}, {"db": "pmc", "key": "PMC8327278"}], "notes": [], "created": "2021-08-11T14:41:45.678Z", "modified": "2021-08-11T14:41:45.689Z"}, {"entity": "publication", "iuid": "b1a31e2f8897420b92fc5124af260100", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1a31e2f8897420b92fc5124af260100.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1a31e2f8897420b92fc5124af260100"}}, "title": "Psychological distress among health professional students during the COVID-19 outbreak", "authors": [{"family": "Li", "given": "Yuchen", "initials": "Y"}, {"family": "Wang", "given": "Yue", "initials": "Y"}, {"family": "Jiang", "given": "Jingwen", "initials": "J"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA", "orcid": "0000-0001-5382-946X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87d1dbec7c6f4942b1db2b999eeb9ece.json"}}, {"family": "Fall", "given": "Katja", "initials": "K", "orcid": "0000-0002-3649-2639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa0adf9b952e4e998c4a2deb07be5907.json"}}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Song", "given": "Huan", "initials": "H"}, {"family": "Lu", "given": "Donghao", "initials": "D"}, {"family": "Zhang", "given": "Wei", "initials": "W", "orcid": "0000-0003-3113-9577", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3cc118af29054fc59971e82c3a711740.json"}}], "type": "journal-article", "published": "2021-08-00", "journal": {"title": "Psychol Med", "issn": "0033-2917", "issn-l": null, "volume": "51", "issue": "11", "pages": "1952-1954"}, "abstract": "Due to the drastic surge of COVID-19 patients, many countries are considering or already graduating health professional students early to aid professional resources. We aimed to assess outbreak-related psychological distress and symptoms of acute stress reaction (ASR) in health professional students and to characterize individuals with potential need for interventions.\n\nWe conducted a prospective cohort study of 1442 health professional students at Sichuan University, China. At baseline (October 2019), participants were assessed for childhood adversity, stressful life events, internet addiction, and family functioning. Using multivariable logistic regression, we examined associations of the above exposures with subsequent psychological distress and ASR in response to the outbreak.\n\nThree hundred and eighty-four (26.63%) participants demonstrated clinically significant psychological distress, while 160 (11.10%) met the criterion for a probable ASR. Individuals who scored high on both childhood adversity and stressful life event experiences during the past year were at increased risks of both distress (ORs 2.00-2.66) and probable ASR (ORs 2.23-3.10), respectively. Moreover, internet addiction was associated with elevated risks of distress (OR 2.05, 95% CI 1.60-2.64) and probable ASR (OR 2.15, 95% CI 1.50-3.10). By contrast, good family functioning was associated with decreased risks of distress (OR 0.43, 95% CI 0.33-0.55) and probable ASR (OR 0.48, 95% CI 0.33-0.69). All associations were independent of baseline psychological distress.\n\nOur findings suggest that COVID-19 related psychological distress and high symptoms burden of ASR are common among health professional students. Extended family and professional support should be considered for vulnerable individuals during these unprecedented times.", "doi": "10.1017/s0033291720001555", "pmid": "32389148", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0033291720001555"}, {"db": "pmc", "key": "PMC7225209"}], "notes": [], "created": "2020-11-25T07:53:07.503Z", "modified": "2021-12-06T13:10:39.089Z"}, {"entity": "publication", "iuid": "e6e339fe0d2a4d418964a3c67e2f51f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6e339fe0d2a4d418964a3c67e2f51f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6e339fe0d2a4d418964a3c67e2f51f8"}}, "title": "Plasma ACE2 species are differentially altered in COVID-19 patients.", "authors": [{"family": "Garc\u00eda-Ayll\u00f3n", "given": "Mar\u00eda-Salud", "initials": "MS"}, {"family": "Moreno-P\u00e9rez", "given": "Oscar", "initials": "O"}, {"family": "Garc\u00eda-Arriaza", "given": "Juan", "initials": "J"}, {"family": "Ramos-Rinc\u00f3n", "given": "Jos\u00e9-Manuel", "initials": "JM"}, {"family": "Cort\u00e9s-G\u00f3mez", "given": "Mar\u00eda-\u00c1ngeles", "initials": "M\u00c1"}, {"family": "Brinkmalm", "given": "Gunnar", "initials": "G"}, {"family": "Andr\u00e9s", "given": "Mariano", "initials": "M"}, {"family": "Le\u00f3n-Ram\u00edrez", "given": "Jos\u00e9-Manuel", "initials": "JM"}, {"family": "Boix", "given": "Vicente", "initials": "V"}, {"family": "Gil", "given": "Joan", "initials": "J"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Esteban", "given": "Mariano", "initials": "M"}, {"family": "Merino", "given": "Esperanza", "initials": "E"}, {"family": "S\u00e1ez-Valero", "given": "Javier", "initials": "J", "orcid": "0000-0001-7480-320X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/848e18c69576492a91a7aa35cee7f632.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "FASEB J", "issn": "1530-6860", "volume": "35", "issue": "8", "pages": "e21745", "issn-l": null}, "abstract": "Studies are needed to identify useful biomarkers to assess the severity and prognosis of COVID-19 disease, caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) virus. Here, we examine the levels of various plasma species of the SARS-CoV-2 host receptor, the angiotensin-converting enzyme 2 (ACE2), in patients at different phases of the infection. Human plasma ACE2 species were characterized by immunoprecipitation and western blotting employing antibodies against the ectodomain and the C-terminal domain, using a recombinant human ACE2 protein as control. In addition, changes in the cleaved and full-length ACE2 species were also examined in serum samples derived from humanized K18-hACE2 mice challenged with a lethal dose of SARS-CoV-2. ACE2 immunoreactivity was present in human plasma as several molecular mass species that probably comprise truncated (70 and 75 kDa) and full-length forms (95, 100, 130, and 170 kDa). COVID-19 patients in the acute phase of infection (n = 46) had significantly decreased levels of ACE2 full-length species, while a truncated 70-kDa form was marginally higher compared with non-disease controls (n = 26). Levels of ACE2 full-length species were in the normal range in patients after a recovery period with an interval of 58-70 days (n = 29), while the 70-kDa species decreased. Levels of the truncated ACE2 species served to discriminate between individuals infected by SARS-CoV-2 and those infected with influenza A virus (n = 17). In conclusion, specific plasma ACE2 species are altered in patients with COVID-19 and these changes normalize during the recovery phase. Alterations in ACE2 species following SARS-CoV-2 infection warrant further investigation regarding their potential usefulness as biomarkers for the disease process and to asses efficacy during vaccination.", "doi": "10.1096/fj.202100051R", "pmid": "34191346", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-07-05T14:25:00.186Z", "modified": "2021-07-05T14:25:00.235Z"}, {"entity": "publication", "iuid": "c9a99007569a4d118c6ea72f0552fe9f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9a99007569a4d118c6ea72f0552fe9f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9a99007569a4d118c6ea72f0552fe9f"}}, "title": "Neurochemical signs of astrocytic and neuronal injury in acute COVID-19 normalizes during long-term follow-up.", "authors": [{"family": "Kanberg", "given": "Nelly", "initials": "N", "orcid": "0000-0002-1064-995X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/84d593bfda8f42688e9d4fe713158679.json"}}, {"family": "Simr\u00e9n", "given": "Joel", "initials": "J", "orcid": "0000-0001-5081-6604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00690c8e16a545aea824cdf580837500.json"}}, {"family": "Ed\u00e9n", "given": "Arvid", "initials": "A"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ"}, {"family": "Sundvall", "given": "P\u00e4r-Daniel", "initials": "PD"}, {"family": "Nellg\u00e5rd", "given": "Bengt", "initials": "B"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": "70", "issue": null, "pages": "103512"}, "abstract": "Neurologic manifestations are well-recognized features of coronavirus disease 2019 (COVID-19). However, the longitudinal association of biomarkers reflecting CNS impact and neurological symptoms is not known. We sought to determine whether plasma biomarkers of CNS injury were associated with neurologic sequelae after COVID-19.\n\nPatients with confirmed acute COVID-19 were studied prospectively. Neurological symptoms were recorded during the acute phase of the disease and at six months follow-up, and blood samples were collected longitudinally. Healthy age-matched individuals were included as controls. We analysed plasma concentrations of neurofilament light-chain (NfL), glial fibrillary acidic protein (GFAp), and growth differentiation factor 15 (GDF-15).\n\nOne hundred patients with mild (n = 24), moderate (n = 28), and severe (n = 48) COVID-19 were followed for a median (IQR) of 225 (187-262) days. In the acute phase, patients with severe COVID-19 had higher concentrations of NfL than all other groups (all p < 0\u00b7001), and higher GFAp than controls (p < 0\u00b7001). GFAp was also significantly increased in moderate disease (p < 0\u00b705) compared with controls. NfL (r = 0\u00b753, p < 0\u00b7001) and GFAp (r = 0\u00b739, p < 0\u00b7001) correlated with GDF-15 during the acute phase. After six months, NfL and GFAp concentrations had normalized, with no persisting group differences. Despite this, 50 patients reported persistent neurological symptoms, most commonly fatigue (n = 40), \"brain-fog\" (n = 29), and changes in cognition (n = 25). We found no correlation between persistent neurological symptoms and CNS injury biomarkers in the acute phase.\n\nThe normalization of CNS injury biomarkers in all individuals, regardless of previous disease severity or persisting neurological symptoms, indicates that post COVID-19 neurological sequelae are not accompanied by ongoing CNS injury.\n\nThe Swedish State Support for Clinical Research, SciLifeLab Sweden, and the Knut and Alice Wallenberg Foundation have provided funding for this project.", "doi": "10.1016/j.ebiom.2021.103512", "pmid": "34333238", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pmc", "key": "PMC8320425"}, {"db": "pii", "key": "S2352-3964(21)00305-4"}], "notes": [], "created": "2021-08-04T10:16:45.714Z", "modified": "2023-06-19T14:46:01.082Z"}, {"entity": "publication", "iuid": "6ee34e8dbbdc4f9ea7f914fddabc947a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ee34e8dbbdc4f9ea7f914fddabc947a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ee34e8dbbdc4f9ea7f914fddabc947a"}}, "title": "Natural killer cells and unconventional T cells in COVID-19", "authors": [{"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Ponzetta", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3224-802X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8d6bca49dc24e558ca8f0b3637d7702.json"}}], "type": "journal-article", "published": "2021-08-00", "journal": {"title": "Current Opinion in Virology", "issn": "1879-6257", "issn-l": null, "volume": "49", "issue": null, "pages": "176-182"}, "abstract": null, "doi": "10.1016/j.coviro.2021.06.005", "pmid": "34217135", "labels": {"Type: Review": null, "Funder: VR": null, "Funder: H2020": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [], "notes": [], "created": "2021-06-21T05:55:32.100Z", "modified": "2021-12-12T18:08:46.036Z"}, {"entity": "publication", "iuid": "8425f513719f4c8c92b50fc93ef47bc4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8425f513719f4c8c92b50fc93ef47bc4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8425f513719f4c8c92b50fc93ef47bc4"}}, "title": "Measuring oxygen access: lessons from health facility assessments in Lagos, Nigeria.", "authors": [{"family": "Graham", "given": "Hamish R", "initials": "HR", "orcid": "0000-0003-2461-0463", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d2d23d0b7dc40f3979a4342d3898649.json"}}, {"family": "Olojede", "given": "Omotayo E", "initials": "OE"}, {"family": "Bakare", "given": "Ayobami A", "initials": "AA"}, {"family": "Iuliano", "given": "Agnese", "initials": "A"}, {"family": "Olatunde", "given": "Oyaniyi", "initials": "O"}, {"family": "Isah", "given": "Adamu", "initials": "A"}, {"family": "Osebi", "given": "Adams", "initials": "A"}, {"family": "Ahmed", "given": "Tahlil", "initials": "T"}, {"family": "Uchendu", "given": "Obioma C", "initials": "OC"}, {"family": "Burgess", "given": "Rochelle", "initials": "R", "orcid": "0000-0001-9749-7065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f890d7dbdea04ac09c689b6c612baa26.json"}}, {"family": "McCollum", "given": "Eric", "initials": "E"}, {"family": "Colbourn", "given": "Tim", "initials": "T", "orcid": "0000-0002-6917-6552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2cccce75e4b4602ab197604cb444a0a.json"}}, {"family": "King", "given": "Carina", "initials": "C", "orcid": "0000-0002-6885-6716", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8ac349483b74803a39b937bf149c480.json"}}, {"family": "Falade", "given": "Adegoke G", "initials": "AG"}, {"family": "INSPIRING Project Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "8", "issn-l": "2059-7908"}, "abstract": "The COVID-19 pandemic has highlighted global oxygen system deficiencies and revealed gaps in how we understand and measure 'oxygen access'. We present a case study on oxygen access from 58 health facilities in Lagos state, Nigeria. We found large differences in oxygen access between facilities (primary vs secondary, government vs private) and describe three key domains to consider when measuring oxygen access: availability, cost, use. Of 58 facilities surveyed, 8 (14%) of facilities had a functional pulse oximeter. Oximeters (N=27) were typically located in outpatient clinics (12/27, 44%), paediatric ward (6/27, 22%) or operating theatre (4/27, 15%). 34/58 (59%) facilities had a functional source of oxygen available on the day of inspection, of which 31 (91%) facilities had it available in a single ward area, typically the operating theatre or maternity ward. Oxygen services were free to patients at primary health centres, when available, but expensive in hospitals and private facilities, with the median cost for 2 days oxygen 13 000 (US$36) and 27 500 (US$77) Naira, respectively. We obtained limited data on the cost of oxygen services to facilities. Pulse oximetry use was low in secondary care facilities (32%, 21/65 patients had SpO2 documented) and negligible in private facilities (2%, 3/177) and primary health centres (<1%, 2/608). We were unable to determine the proportion of hypoxaemic patients who received oxygen therapy with available data. However, triangulation of existing data suggested that no facilities were equipped to meet minimum oxygen demands. We highlight the importance of a multifaceted approach to measuring oxygen access that assesses access at the point-of-care and ideally at the patient-level. We propose standard metrics to report oxygen access and describe how these can be integrated into routine health information systems and existing health facility assessment tools.", "doi": "10.1136/bmjgh-2021-006069", "pmid": "34344666", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-006069"}], "notes": [], "created": "2021-08-06T09:49:48.615Z", "modified": "2021-08-06T09:51:35.891Z"}, {"entity": "publication", "iuid": "1d66b977d13240398ce77404977f48d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d66b977d13240398ce77404977f48d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d66b977d13240398ce77404977f48d7"}}, "title": "Low admission protein C levels are a risk factor for disease worsening and mortality in hospitalized patients with COVID-19", "authors": [{"family": "Stanne", "given": "Tara M", "initials": "TM"}, {"family": "Pedersen", "given": "Annie", "initials": "A"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Jern", "given": "Christina", "initials": "C"}], "type": "journal-article", "published": "2021-08-00", "journal": {"title": "Thromb Res", "issn": "0049-3848", "volume": "204", "issue": null, "pages": "13-15", "issn-l": null}, "abstract": null, "doi": "10.1016/j.thromres.2021.05.016", "pmid": "34102452", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [], "notes": [], "created": "2021-06-09T19:02:28.905Z", "modified": "2021-06-10T10:15:42.634Z"}, {"entity": "publication", "iuid": "92f2c01548f4465b9ea64f67b973df7d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/92f2c01548f4465b9ea64f67b973df7d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/92f2c01548f4465b9ea64f67b973df7d"}}, "title": "Impact of the Alpha VOC on disease severity in SARS-CoV-2-positive adults in Sweden", "authors": [{"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-8801-3169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37509c3832244b019b91a1fe2cbe183e.json"}}, {"family": "Bruce", "given": "Daniel", "initials": "D"}, {"family": "Wahlstr\u00f6m", "given": "Erik", "initials": "E", "orcid": "0000-0002-0800-8520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f623177f84a4f4ba85571b106e4cec5.json"}}, {"family": "Walther", "given": "Sten", "initials": "S", "orcid": "0000-0002-3862-2556", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f835267776274befa3013a432790de71.json"}}, {"family": "Carnahan", "given": "Moa Rehn, AnnaSara", "initials": "MRA", "orcid": "0000-0002-3940-4323", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ce1cef1f776424a977f2e21f38ff05e.json"}}, {"family": "Andersson", "given": "Emmi", "initials": "E"}, {"family": "Bark", "given": "Anna M Bennet", "initials": "AMB", "orcid": "0000-0003-2704-2625", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa79f4ac2db849368192a91c01cd370a.json"}}, {"family": "Hanberger", "given": "H\u00e5kan", "initials": "H", "orcid": "0000-0002-4199-0229", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ccccceb630874fc5ab7507a313b59039.json"}}], "type": "journal-article", "published": "2021-08-00", "journal": {"title": "J Infect", "issn": "0163-4453", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jinf.2021.08.043", "pmid": "34474056", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "S0163-4453(21)00448-5"}, {"db": "pmc", "key": "PMC8405243"}], "notes": [], "created": "2021-09-06T06:05:00.631Z", "modified": "2021-11-19T11:22:16.947Z"}, {"entity": "publication", "iuid": "fbc72c1d65a94e25b57a9ba3da49b44c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fbc72c1d65a94e25b57a9ba3da49b44c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fbc72c1d65a94e25b57a9ba3da49b44c"}}, "title": "Fostering healthy aging: The interdependency of infections, immunity and frailty.", "authors": [{"family": "Vetrano", "given": "Davide L", "initials": "DL", "orcid": "0000-0002-3099-4830", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0124721bb214413a34c965b6accc64b.json"}}, {"family": "Triolo", "given": "Federico", "initials": "F"}, {"family": "Maggi", "given": "Stefania", "initials": "S"}, {"family": "Malley", "given": "Richard", "initials": "R"}, {"family": "Jackson", "given": "Thomas A", "initials": "TA"}, {"family": "Poscia", "given": "Andrea", "initials": "A", "orcid": "0000-0002-7616-3389", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0a468effc7749f193226a16c27c7b18.json"}}, {"family": "Bernabei", "given": "Roberto", "initials": "R"}, {"family": "Ferrucci", "given": "Luigi", "initials": "L"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Ageing Res Rev", "issn": "1872-9649", "volume": "69", "issue": null, "pages": "101351", "issn-l": "1568-1637"}, "abstract": "Untangling the interdependency of infections, immunity and frailty may help to clarify their roles in the maintenance of health in aging individuals, and the recent COVID-19 pandemic has further highlighted such priority. In this scoping review we aimed to systematically collect the evidence on 1) the impact of common infections such as influenza, pneumonia and varicella zoster on frailty development, and 2) the role played by frailty in the response to immunization of older adults. Findings are discussed under a unifying framework to identify knowledge gaps and outline their clinical and public health implications to foster a healthier aging. Twenty-nine studies (113,863 participants) selected to answer the first question provided a moderately strong evidence of an association between infections and physical as well as cognitive decline - two essential dimensions of frailty. Thirteen studies (34,520 participants) investigating the second aim, showed that frailty was associated with an impaired immune response in older ages, likely due to immunosenescence. However, the paucity of studies, the absence of tools to predict vaccine efficacy, and the lack of studies investigating the efficacy of newer vaccines in presence of frailty, strongly limit the formulation of more personalized immunization strategies for older adults. The current evidence suggests that infections and frailty repeatedly cross each other pathophysiological paths and accelerate the aging process in a vicious circle. Such evidence opens to several considerations. First, the prevention of both conditions pass through a life course approach, which includes several individual and societal aspects. Second, the maintenance of a well-functioning immune system may be accomplished by preventing frailty, and vice versa. Third, increasing the adherence to immunization may delay the onset of frailty and maintain the immune system homeostasis, beyond preventing infections.", "doi": "10.1016/j.arr.2021.101351", "pmid": "33971332", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC9588151"}, {"db": "pii", "key": "S1568-1637(21)00098-2"}], "notes": [], "created": "2021-05-17T19:01:01.504Z", "modified": "2023-06-19T15:29:33.054Z"}, {"entity": "publication", "iuid": "e2899a4f5e3b42c58bf8868d706a73db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2899a4f5e3b42c58bf8868d706a73db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2899a4f5e3b42c58bf8868d706a73db"}}, "title": "Evidence-based public policy making for medicines across countries: findings and implications for the future.", "authors": [{"family": "Godman", "given": "Brian", "initials": "B", "orcid": "0000-0001-6539-6972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e76103610619453b84eab8de36f169cc.json"}}, {"family": "Fadare", "given": "Joseph", "initials": "J", "orcid": "0000-0002-5641-1402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0cd3e8ea7e09469ab822edbaa7f57830.json"}}, {"family": "Kwon", "given": "Hye-Young", "initials": "HY", "orcid": "0000-0001-9772-1354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/935f3f4bd268497aa8bfb936216ab36e.json"}}, {"family": "Dias", "given": "Carolina Zampirolli", "initials": "CZ", "orcid": "0000-0003-2181-4268", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d27ffebfe3ca4a61a66559b3e9927fc9.json"}}, {"family": "Kurdi", "given": "Amanj", "initials": "A", "orcid": "0000-0001-5036-1988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be9bf17786754363929dc0faaae8c323.json"}}, {"family": "Dias God\u00f3i", "given": "Isabella Piassi", "initials": "IP", "orcid": "0000-0002-0568-6625", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6ade8b9c4e94a64add5b0d5b6911a27.json"}}, {"family": "Kibuule", "given": "Dan", "initials": "D", "orcid": "0000-0002-6908-2177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4344137451d04535a5875183b9abc24e.json"}}, {"family": "Hoxha", "given": "Iris", "initials": "I"}, {"family": "Opanga", "given": "Sylvia", "initials": "S"}, {"family": "Saleem", "given": "Zikria", "initials": "Z", "orcid": "0000-0003-3202-6347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/029d4b30cc724148a1225090d3f063ee.json"}}, {"family": "Bochenek", "given": "Tomasz", "initials": "T", "orcid": "0000-0001-9915-7267", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce6242842ee44d19808be95b7a3196d3.json"}}, {"family": "Markovi\u0107-Pekovi\u0107", "given": "Vanda", "initials": "V", "orcid": "0000-0001-8963-5720", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb251c8af64542caa7bb5728b7348ef7.json"}}, {"family": "Mardare", "given": "Ileana", "initials": "I", "orcid": "0000-0002-4725-9808", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d95ddb606d24f5099c75a2e9f8db778.json"}}, {"family": "Kalungia", "given": "Aubrey C", "initials": "AC", "orcid": "0000-0003-2554-1236", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d9dffebafbd4ac2ba111bdb7b32876d.json"}}, {"family": "Campbell", "given": "Stephen", "initials": "S", "orcid": "0000-0002-2328-4136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ca866e1934246d1a368303f3cd026b5.json"}}, {"family": "Allocati", "given": "Eleonora", "initials": "E"}, {"family": "Pisana", "given": "Alice", "initials": "A"}, {"family": "Martin", "given": "Antony P", "initials": "AP", "orcid": "0000-0003-4383-6038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6a0ea83af464d6fa0ec04b3e333fcab.json"}}, {"family": "Meyer", "given": "Johanna C", "initials": "JC", "orcid": "0000-0003-0462-5713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b517b46322e64403aee5b49f60da3ac4.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "J Comp Eff Res", "issn": "2042-6313", "volume": "10", "issue": "12", "pages": "1019-1052", "issn-l": null}, "abstract": "Aim: Global expenditure on medicines is rising up to 6% per year driven by increasing prevalence of non-communicable diseases (NCDs) and new premium priced medicines for cancer, orphan diseases and other complex areas. This is difficult to sustain without reforms. Methods: Extensive narrative review of published papers and contextualizing the findings to provide future guidance. Results: New models are being introduced to improve the managed entry of new medicines including managed entry agreements, fair pricing approaches and monitoring prescribing against agreed guidance. Multiple measures have also successfully been introduced to improve the prescribing of established medicines. This includes encouraging greater prescribing of generics and biosimilars versus originators and patented medicines in a class to conserve resources without compromising care. In addition, reducing inappropriate antibiotic utilization. Typically, multiple measures are the most effective. Conclusion: Multiple measures will be needed to attain and retain universal healthcare.", "doi": "10.2217/cer-2020-0273", "pmid": "34241546", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:59:09.733Z", "modified": "2021-08-06T07:59:09.998Z"}, {"entity": "publication", "iuid": "8af2b1eadc0942f19199db9b059a446b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8af2b1eadc0942f19199db9b059a446b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8af2b1eadc0942f19199db9b059a446b"}}, "title": "Emotions during the Covid-19 pandemic: Fear, anxiety, and anger as mediators between threats and policy support and political actions.", "authors": [{"family": "Renstr\u00f6m", "given": "Emma A", "initials": "EA", "orcid": "0000-0001-6593-2464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c969b46ee25b4276916587537076440c.json"}}, {"family": "B\u00e4ck", "given": "Hanna", "initials": "H"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "J Appl Soc Psychol", "issn": "0021-9029", "issn-l": null, "volume": "51", "issue": "8", "pages": "861-877"}, "abstract": "The Covid-19 pandemic has significantly changed the lives of most people. It has been described as the most severe global health disaster of modern times by the United Nations. No doubt such a major crisis influences what citizens think of different policies, and how they become politically active, not to mention, the forceful emotional experiences that the Covid-19 pandemic brings. This study evaluates how emotions affect support for policies related to restricting the spread of the virus and economic assistance, and how emotions affect intentions to engage politically. In an experiment (N = 1,072), we manipulated emotional reactions to threat by highlighting different aspects of the pandemic. Our findings show that different experimental treatments elicit different emotions, and that fear, anxiety, and anger are all related to policy support and political action intentions, but in different ways. Fear and anger predict support for restrictive policies to limit the spread of the virus, while anxiety predicts support for economic policies. Anger and anxiety, but not fear, increase intentions to engage politically. Hence, we find support for a mechanism where different aspects of the Covid-19 crisis evoke different emotional reactions, which in turn affects policy support and political actions differently.", "doi": "10.1111/jasp.12806", "pmid": "34511637", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "JASP12806"}, {"db": "pmc", "key": "PMC8420191"}], "notes": [], "created": "2021-09-20T06:35:30.177Z", "modified": "2022-11-23T08:54:37.258Z"}, {"entity": "publication", "iuid": "4e9563984492429597bcad2167bf9b30", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4e9563984492429597bcad2167bf9b30.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4e9563984492429597bcad2167bf9b30"}}, "title": "Does the Covid-19 pandemic affect ankle fracture incidence? Moderate decrease in Sweden.", "authors": [{"family": "Rydberg", "given": "Emilia M\u00f6ller", "initials": "EM"}, {"family": "M\u00f6ller", "given": "Michael", "initials": "M"}, {"family": "Ekelund", "given": "Jan", "initials": "J"}, {"family": "Wolf", "given": "Olof", "initials": "O"}, {"family": "Wennergren", "given": "David", "initials": "D"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Acta Orthop", "issn": "1745-3682", "volume": "92", "issue": "4", "pages": "381-384", "issn-l": null}, "abstract": "Background and purpose - While many other countries implemented strict regulations and restrictions for their citizens during the 1st wave of the Covid-19 pandemic, Sweden maintained a more restrained approach. The Swedish Public Health Agency emphasized individual responsibility and pushed for behavioral changes. With strict lockdown a 77% decrease in ankle fracture incidence has been reported. We investigated whether there was a change in the incidence of ankle fractures seen at 7 selected hospitals during the Covid-19 pandemic 2020.Patients and methods - Data on all ankle fractures treated at 7 selected departments during March 15 through June 15, 2020, and for the same period in the preceding 3 years (2017-2019), was retrieved from the Swedish Fracture Register. The number of fractures during the whole period and subsequent 30-day periods were compared between 2020 and 2017-2019, including subgroup analyses of age and sex.Results - The monthly rate of ankle fractures was reduced by 14% in 2020 (139 fractures) compared with 2017-2019 (161 fractures). Women had a 16% decrease and patients aged > 70 years had a 29% decrease. During the 1st 30-day period, a 26% decrease in fractures was seen.Interpretation - During the 1st wave of the Covid-19 pandemic, a moderate decline in the number of ankle fractures was seen. Women and patients aged > 70 years displayed the greatest reduction. The greatest reduction in incidence of fractures was seen during the 1st 30-day period. This indicates greater adherence to government recommendations regarding social distancing in these subgroups and during the 1st month of the pandemic. Changes in ankle fracture incidence may be a measure of lockdown extent.", "doi": "10.1080/17453674.2021.1907517", "pmid": "33821759", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8381968"}], "notes": [], "created": "2021-04-07T10:08:29.763Z", "modified": "2023-01-13T14:44:23.002Z"}, {"entity": "publication", "iuid": "9bdd9b267bc0427a8658fda308767fce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9bdd9b267bc0427a8658fda308767fce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9bdd9b267bc0427a8658fda308767fce"}}, "title": "Diagnostics and management of tuberculosis and COVID-19 in a patient with pneumothorax (clinical case).", "authors": [{"family": "Starshinova", "given": "A", "initials": "A"}, {"family": "Guglielmetti", "given": "L", "initials": "L"}, {"family": "Rzhepishevska", "given": "O", "initials": "O"}, {"family": "Ekaterincheva", "given": "O", "initials": "O"}, {"family": "Zinchenko", "given": "Yu", "initials": "Y"}, {"family": "Kudlay", "given": "D", "initials": "D"}], "type": "case reports", "published": "2021-08-00", "journal": {"title": "J Clin Tuberc Other Mycobact Dis", "issn": "2405-5794", "volume": "24", "pages": "100259", "issn-l": null}, "abstract": "The spread of COVID-19 in countries with high and medium incidence of tuberculosis has led to an increased risk of COVID-19 and tuberculosis co-infection, introducing new diagnostic and therapeutic challenges for the clinician. Hereby we describe a first case where tuberculosis and COVID-19 were diagnosed concomitantly in a Russian patient with pneumothorax. We discuss the challenges associated with the diagnosis and treatment of tuberculosis during the COVID-19 pandemic.", "doi": "10.1016/j.jctube.2021.100259", "pmid": "34235277", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2405-5794(21)00048-6"}, {"db": "pmc", "key": "PMC8245665"}], "notes": [], "created": "2021-08-06T08:23:23.405Z", "modified": "2021-08-06T08:24:22.465Z"}, {"entity": "publication", "iuid": "c47cff1970a64cb7bf6108777ab2b756", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c47cff1970a64cb7bf6108777ab2b756.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c47cff1970a64cb7bf6108777ab2b756"}}, "title": "Determinants for hospitalisations, intensive care unit admission and death among 20,293 reported COVID-19 cases in Portugal, March to April 2020.", "authors": [{"family": "Ricoca Peixoto", "given": "Vasco", "initials": "V"}, {"family": "Vieira", "given": "Andr\u00e9", "initials": "A"}, {"family": "Aguiar", "given": "Pedro", "initials": "P"}, {"family": "Sousa", "given": "Paulo", "initials": "P"}, {"family": "Carvalho", "given": "Carlos", "initials": "C"}, {"family": "Thomas", "given": "Daniel", "initials": "D"}, {"family": "Abrantes", "given": "Alexandre", "initials": "A"}, {"family": "Nunes", "given": "Carla", "initials": "C"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "33", "pages": null}, "abstract": "BackgroundDeterminants of hospitalisation, intensive care unit (ICU) admission and death are still unclear for COVID-19. Few studies have adjusted for confounding for different clinical outcomes including all reported cases within a country.AimWe used routine surveillance data from Portugal to identify risk factors for severe COVID-19 outcomes, and to support risk stratification, public health interventions, and planning of healthcare resources.MethodsWe conducted a retrospective cohort study including 20,293 laboratory-confirmed cases of COVID-19 reported between 1 March and 28 April 2020 through the national epidemiological surveillance system. We calculated absolute risk, relative risk (RR) and adjusted relative risk (aRR) to identify demographic and clinical factors associated with hospitalisation, ICU admission and death using Poisson regressions.ResultsIncreasing age (\u2265 60 years) was the major determinant for all outcomes. Age \u2265 90 years was the strongest determinant of hospital admission (aRR: 6.1), and 70-79 years for ICU (aRR: 10.4). Comorbidities of cardiovascular, immunodeficiency, kidney and lung disease (aRR: 4.3, 2.8, 2.4, 2.0, respectively) had stronger associations with ICU admission, while for death they were kidney, cardiovascular and chronic neurological disease (aRR: 2.9, 2.6, 2.0).ConclusionsOlder age was the strongest risk factor for all severe outcomes. These findings from the early stages of the COVID-19 pandemic support risk-stratified public health measures that should prioritise protecting older people. Epidemiological scenarios and clinical guidelines should consider this, even though under-ascertainment should also be considered.", "doi": "10.2807/1560-7917.ES.2021.26.33.2001059", "pmid": "34414882", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-27T09:44:40.422Z", "modified": "2021-11-18T12:57:57.607Z"}, {"entity": "publication", "iuid": "8912dbd2cef94ff1910c5711bf0b7f83", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8912dbd2cef94ff1910c5711bf0b7f83.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8912dbd2cef94ff1910c5711bf0b7f83"}}, "title": "Comorbidity status of deceased COVID-19 in-patients in Italy.", "authors": [{"family": "Vetrano", "given": "Davide Liborio", "initials": "DL", "orcid": "0000-0002-3099-4830", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0124721bb214413a34c965b6accc64b.json"}}, {"family": "Tazzeo", "given": "Clare", "initials": "C"}, {"family": "Palmieri", "given": "Luigi", "initials": "L"}, {"family": "Marengoni", "given": "Alessandra", "initials": "A"}, {"family": "Zucchelli", "given": "Alberto", "initials": "A"}, {"family": "Lo Noce", "given": "Cinzia", "initials": "C"}, {"family": "Onder", "given": "Graziano", "initials": "G"}, {"family": "Italian National Institute of Health Covid-Mortality Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Aging Clin Exp Res", "issn": "1720-8319", "issn-l": "1594-0667", "volume": "33", "issue": "8", "pages": "2361-2365"}, "abstract": "Most COVID-19-related deaths have occurred in older persons with comorbidities. Specific patterns of comorbidities related to COVID-19 deaths have not been investigated.\n\nA random sample of 6085 individuals in Italy who died in-hospital with confirmed COVID-19 between February and December 2020 were included. Observed to expected (O/E) ratios of disease pairs were computed and logistic regression models were used to determine the association between disease pairs with O/E values \u2265 1.5.\n\nSix pairs of diseases exhibited O/E values \u2265 1.5 and statistically significant higher odds of co-occurrence in the crude and adjusted analyses: (1) ischemic heart disease and atrial fibrillation, (2) atrial fibrillation and heart failure, (3) atrial fibrillation and stroke, (4) heart failure and COPD, (5) stroke and dementia, and (6) type 2 diabetes and obesity.\n\nIn those deceased in-hospital due to COVID-19 in Italy, disease combinations defined by multiple cardio-respiratory, metabolic, and neuropsychiatric diseases occur more frequently than expected. This finding indicates a need to investigate the possible role of these clinical profiles in the chain of events that lead to death in individuals who have contracted SARS-CoV-2.", "doi": "10.1007/s40520-021-01914-y", "pmid": "34169447", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8224257"}, {"db": "pii", "key": "10.1007/s40520-021-01914-y"}], "notes": [], "created": "2021-06-28T18:14:36.919Z", "modified": "2023-06-19T15:29:44.970Z"}, {"entity": "publication", "iuid": "db66a5d743f54eb4b1dd5e5a1d97a38a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db66a5d743f54eb4b1dd5e5a1d97a38a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db66a5d743f54eb4b1dd5e5a1d97a38a"}}, "title": "Antibody responses after a single dose of ChAdOx1 nCoV-19 vaccine in healthcare workers previously infected with SARS-CoV-2.", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f28f2f6ac9648629c2d2de92fe7bb59.json"}}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/305bca9e5c6c423898c272bf06ce2f2a.json"}}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Salomonsson", "given": "Ann-Christin", "initials": "AC"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1345-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a53a433db6f04a458e3d420f0c9995c5.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": "70", "issue": null, "pages": "103523"}, "abstract": "Recent reports demonstrate robust serological responses to a single dose of messenger RNA (mRNA) vaccines in individuals previously infected with SARS-CoV-2. Data on immune responses following a single-dose adenovirus-vectored vaccine expressing the SARS-CoV-2 spike protein (ChAdOx1 nCoV-19) in individuals with previous SARS-CoV-2 infection are however limited, and current guidelines recommend a two-dose regimen regardless of preexisting immunity.\n\nWe compared RBD-specific IgG and RBD-ACE2 blocking antibodies against SARS-CoV-2 wild type and variants of concern following two doses of the mRNA vaccine BNT162b2 in SARS-CoV-2 na\u00efve healthcare workers (n=65) and a single dose of the adenovector vaccine ChAdOx1 nCoV-19 in 82 healthcare workers more than (n=45) and less than (n=37) 11 months post mild SARS-CoV-2 infection at time of vaccination.\n\nThe post-vaccine levels of RBD-specific IgG and neutralizing antibodies against the SARS-CoV-2 wild type and variants of concern including Delta lineage 1.617.2 were similar or higher in participants receiving a single dose of ChAdOx1 nCoV-19 vaccine post SARS-CoV-2 infection (both more than and less than 11 months post infection) compared to SARS-CoV-2 na\u00efve participants who received two doses of BNT162b2 vaccine.\n\nOur data support that a single dose ChAdOx1 nCoV-19 vaccine that is administered up to at least 11 months post SARS-CoV-2 infection serves as an effective immune booster. This provides a possible rationale for a single-dose vaccine regimen.\n\nA full list of funding bodies that contributed to this study can be found in the Acknowledgements section.", "doi": "10.1016/j.ebiom.2021.103523", "pmid": "34391088", "labels": {"Category: Health": null, "Category: Drug Discovery": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Drug discovery and repurposing of drugs": null, "Research Area: Host cell systems biology and targets": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8357428"}, {"db": "pii", "key": "S2352-3964(21)00316-9"}], "notes": [], "created": "2021-05-17T19:14:38.806Z", "modified": "2023-06-19T14:33:13.824Z"}, {"entity": "publication", "iuid": "88644ac51d8c41fcbf8cf8396c907d1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/88644ac51d8c41fcbf8cf8396c907d1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/88644ac51d8c41fcbf8cf8396c907d1d"}}, "title": "A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic.", "authors": [{"family": "Wang", "given": "Ke", "initials": "K", "orcid": "0000-0002-5776-0815", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92a94307dd704b3086b3bc04ccd5dbfc.json"}}, {"family": "Goldenberg", "given": "Amit", "initials": "A"}, {"family": "Dorison", "given": "Charles A", "initials": "CA", "orcid": "0000-0002-7072-2530", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/333f1c9b074c4d38894624278ae79751.json"}}, {"family": "Miller", "given": "Jeremy K", "initials": "JK", "orcid": "0000-0003-4409-7660", "researcher": {"href": 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"https://publications-covid19.scilifelab.se/researcher/d67c255cec3a47b79ddaaf09b6c59cee.json"}}, {"family": "Ebersole", "given": "Charles R", "initials": "CR"}, {"family": "Chartier", "given": "Christopher R", "initials": "CR", "orcid": "0000-0002-4568-4827", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d62a113c9b8447585c9146ebe085e33.json"}}, {"family": "Mallik", "given": "Peter R", "initials": "PR"}, {"family": "Urry", "given": "Heather L", "initials": "HL", "orcid": "0000-0003-4915-1785", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1ef8e659f174f8fa429656c23a05452.json"}}, {"family": "Buchanan", "given": "Erin M", "initials": "EM", "orcid": "0000-0002-9689-4189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5878425d18e4c0cb1fa64b5a63df968.json"}}, {"family": "Coles", "given": "Nicholas A", "initials": "NA", "orcid": "0000-0001-8583-5610", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a0194b331e640dc8548c14eb7e3b2fd.json"}}, {"family": "Primbs", "given": "Maximilian A", "initials": "MA", "orcid": "0000-0002-3398-5569", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96936f42ec994e358255f23d7f969a97.json"}}, {"family": "Basnight-Brown", "given": "Dana M", "initials": "DM", "orcid": "0000-0002-7200-6976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ac1d426131d40eeb088a3ad71fbeb4e.json"}}, {"family": "IJzerman", "given": "Hans", "initials": "H", "orcid": "0000-0002-0990-2276", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0bb878701ae942e19cbb54fa33787a5a.json"}}, {"family": "Forscher", "given": "Patrick S", "initials": "PS", "orcid": "0000-0002-7763-3565", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d5f78c637ff45e6899240ac263367c3.json"}}, {"family": "Moshontz", "given": "Hannah", "initials": "H", "orcid": "0000-0003-4345-3715", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92ab3cbbe34b43abb40476227a7ee357.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Nat Hum Behav", "issn": "2397-3374", "volume": "5", "issue": "8", "pages": "1089-1110", "issn-l": "2397-3374"}, "abstract": "The COVID-19 pandemic has increased negative emotions and decreased positive emotions globally. Left unchecked, these emotional changes might have a wide array of adverse impacts. To reduce negative emotions and increase positive emotions, we tested the effectiveness of reappraisal, an emotion-regulation strategy that modifies how one thinks about a situation. Participants from 87 countries and regions (n = 21,644) were randomly assigned to one of two brief reappraisal interventions (reconstrual or repurposing) or one of two control conditions (active or passive). Results revealed that both reappraisal interventions (vesus both control conditions) consistently reduced negative emotions and increased positive emotions across different measures. Reconstrual and repurposing interventions had similar effects. Importantly, planned exploratory analyses indicated that reappraisal interventions did not reduce intentions to practice preventive health behaviours. The findings demonstrate the viability of creating scalable, low-cost interventions for use around the world. PROTOCOL REGISTRATION: The stage 1 protocol for this Registered Report was accepted in principle on 12 May 2020. The protocol, as accepted by the journal, can be found at https://doi.org/10.6084/m9.figshare.c.4878591.v1.", "doi": "10.1038/s41562-021-01173-x", "pmid": "34341554", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41562-021-01173-x"}, {"db": "URL", "key": "https://osf.io/jeu73/.", "description": "Raw data, processed data and code"}], "notes": [], "created": "2021-08-04T10:08:50.740Z", "modified": "2021-11-18T13:04:43.407Z"}, {"entity": "publication", "iuid": "2636d27430424f9ba9bbc3dcae9d5353", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2636d27430424f9ba9bbc3dcae9d5353.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2636d27430424f9ba9bbc3dcae9d5353"}}, "title": "A health systems resilience research agenda: moving from concept to practice.", "authors": [{"family": "Saulnier", "given": "Dell D", "initials": "DD", "orcid": "0000-0001-7761-0737", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d3fc961101845b1ae844339af7495e4.json"}}, {"family": "Blanchet", "given": "Karl", "initials": "K", "orcid": "0000-0003-0498-8020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aad004843f3f44c8b011feedf86831e1.json"}}, {"family": "Canila", "given": "Carmelita", "initials": "C"}, {"family": "Cobos Mu\u00f1oz", "given": "Daniel", "initials": "D"}, {"family": "Dal Zennaro", "given": "Livia", "initials": "L"}, {"family": "de Savigny", "given": "Don", "initials": "D"}, {"family": "Durski", "given": "Kara N", "initials": "KN", "orcid": "0000-0003-1456-626X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c3c8647d0fb46f3bc270457481eccdb.json"}}, {"family": "Garcia", "given": "Fernando", "initials": "F"}, {"family": "Grimm", "given": "Pauline Yongeun", "initials": "PY"}, {"family": "Kwamie", "given": "Aku", "initials": "A"}, {"family": "Maceira", "given": "Daniel", "initials": "D"}, {"family": "Marten", "given": "Robert", "initials": "R", "orcid": "0000-0002-2416-2309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5304e89b214846d0a6f2097df8eb1439.json"}}, {"family": "Peytremann-Bridevaux", "given": "Isabelle", "initials": "I"}, {"family": "Poroes", "given": "Camille", "initials": "C"}, {"family": "Ridde", "given": "Valery", "initials": "V", "orcid": "0000-0001-9299-8266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e62a45cb15a4d66966e72c363547b2d.json"}}, {"family": "Seematter", "given": "Laurence", "initials": "L"}, {"family": "Stern", "given": "Barbara", "initials": "B"}, {"family": "Suarez", "given": "Patricia", "initials": "P"}, {"family": "Teddy", "given": "Gina", "initials": "G"}, {"family": "Wernli", "given": "Didier", "initials": "D", "orcid": "0000-0002-1751-1961", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d61d17a45a24592aa9bf5ebea861503.json"}}, {"family": "Wyss", "given": "Kaspar", "initials": "K"}, {"family": "Tediosi", "given": "Fabrizio", "initials": "F", "orcid": "0000-0001-8671-9400", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9884188f9c04312b05212ade939818d.json"}}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "8", "issn-l": "2059-7908"}, "abstract": "Health system resilience, known as the ability for health systems to absorb, adapt or transform to maintain essential functions when stressed or shocked, has quickly gained popularity following shocks like COVID-19. The concept is relatively new in health policy and systems research and the existing research remains mostly theoretical. Research to date has viewed resilience as an outcome that can be measured through performance outcomes, as an ability of complex adaptive systems that is derived from dynamic behaviour and interactions, or as both. However, there is little congruence on the theory and the existing frameworks have not been widely used, which as diluted the research applications for health system resilience. A global group of health system researchers were convened in March 2021 to discuss and identify priorities for health system resilience research and implementation based on lessons from COVID-19 and other health emergencies. Five research priority areas were identified: (1) measuring and managing systems dynamic performance, (2) the linkages between societal resilience and health system resilience, (3) the effect of governance on the capacity for resilience, (4) creating legitimacy and (5) the influence of the private sector on health system resilience. A key to filling these research gaps will be longitudinal and comparative case studies that use cocreation and coproduction approaches that go beyond researchers to include policy-makers, practitioners and the public.", "doi": "10.1136/bmjgh-2021-006779", "pmid": "34353820", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-006779"}], "notes": [], "created": "2021-08-11T14:41:14.804Z", "modified": "2021-08-11T14:41:14.962Z"}, {"entity": "publication", "iuid": "21a1ff9833a248a497680dccbef0cb6b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/21a1ff9833a248a497680dccbef0cb6b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/21a1ff9833a248a497680dccbef0cb6b"}}, "title": "Investigating tinnitus subgroups based on hearing-related difficulties.", "authors": [{"family": "Beukes", "given": "Eldr\u00e9 W", "initials": "EW", "orcid": "0000-0002-9434-9160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b5ab9ec02014cd9bd58a095f8175dd2.json"}}, {"family": "Baguley", "given": "David M", "initials": "DM"}, {"family": "Manchaiah", "given": "Vinaya", "initials": "V"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Allen", "given": "Peter M", "initials": "PM"}, {"family": "Kaldo", "given": "Viktor", "initials": "V"}, {"family": "Jacquemin", "given": "Laure", "initials": "L"}, {"family": "Lourenco", "given": "Matheus P C G", "initials": "MPCG"}, {"family": "Onozuka", "given": "Joy", "initials": "J"}, {"family": "Stockdale", "given": "David", "initials": "D"}, {"family": "Maidment", "given": "David W", "initials": "DW"}], "type": "journal article", "published": "2021-07-31", "journal": {"title": "Int J Clin Pract", "issn": "1742-1241", "pages": "e14684", "issn-l": null}, "abstract": "Meaningfully grouping individuals with tinnitus who share the common characteristics (i.e., subgrouping, phenotyping) may help tailor interventions to certain tinnitus subgroups and hence reduce outcome variability. The purpose of this study was to test if the presence of tinnitus subgroups are discernible based on hearing-related comorbidities, and to identify predictors of tinnitus severity for each subgroup identified.\n\nAn exploratory cross-sectional study was used. The study was nested within an online survey distributed worldwide to investigate tinnitus experiences during the COVID-19 pandemic. The main outcome measure was the tinnitus Handicap Inventory- Screening Version RESULTS: From the 3400 respondents, 2,980 were eligible adults with tinnitus with an average age of 58 years (SD= 14.7) with 50% (n= 1,457) being female. A three-cluster solution identified distinct subgroups, namely, those with tinnitus but no hearing loss (n = 1,306; 44%), those presenting with tinnitus and hyperacusis and/or misophonia (n = 795; 27%), and those with tinnitus and hearing loss (n = 879; 29%). Those with tinnitus and hyperacusis reported the highest tinnitus severity (M= 20.3; SD= 10.5) and those with tinnitus and no hearing loss had the lowest tinnitus severity (M= 15.7; SD= 10.4). Younger age and the presence of mental health problems predicted greater tinnitus severity for all groups (\u03b2\u2264 -.1, p\u2264 .016).\n\nFurther exploration of these potential subtypes are needed in both further research and clinical practice by initially triaging tinnitus patients prior to their clinical appointments based on the presence of hearing-related comorbidities. Unique management pathways and interventions could be tailored for each tinnitus subgroup.", "doi": "10.1111/ijcp.14684", "pmid": "34331723", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-04T17:02:52.619Z", "modified": "2021-08-04T17:02:52.661Z"}, {"entity": "publication", "iuid": "1dcc9c1c68f9403da3ab22f2eb3e8cb3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1dcc9c1c68f9403da3ab22f2eb3e8cb3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1dcc9c1c68f9403da3ab22f2eb3e8cb3"}}, "title": "High expression of neutrophil and monocyte CD64 with simultaneous lack of upregulation of adhesion receptors CD11b, CD162, CD15, CD65 on neutrophils in severe COVID-19.", "authors": [{"family": "Karawajczyk", "given": "Malgorzata", "initials": "M", "orcid": "0000-0001-8192-0076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e42747d6ce4241f9aaa79c597475dc62.json"}}, {"family": "Douhan H\u00e5kansson", "given": "Lena", "initials": "L"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Pauksens", "given": "Karlis", "initials": "K"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Larsson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-07-31", "journal": {"title": "Ther Adv Infect Dis", "issn": "2049-9361", "issn-l": null, "volume": "8", "issue": null, "pages": "20499361211034065"}, "abstract": "The pronounced neutrophilia observed in patients with coronavirus disease 2019 (COVID-19) infections suggests a role for these leukocytes in the pathology of the disease. Monocyte and neutrophil expression of CD64 and CD11b have been reported as early biomarkers to detect infections. The aim of this study was to study the expression of receptors for IgG (CD64) and adhesion molecules (CD11b, CD15s, CD65, CD162, CD66b) on neutrophils and monocytes in patients with severe COVID-19 after admission to an intensive care unit (ICU).\n\nThe expression of receptors was analyzed using flow cytometry. EDTA blood from 23 patients with confirmed COVID-19 infection was sampled within 48 h of admission to the ICU. Leukocytes were labeled with antibodies to CD11b, CD15s, CD65s, CD162, CD64, and CD66b. Expression of receptors was reported as mean fluorescence intensity (MFI) or the percentage of cells expressing receptors.\n\nResults are presented as comparison of COVID-19 patients with the healthy group and the receptor expression as MFI. Neutrophil receptors CD64 (2.5 versus 0.5) and CD66b (44.5 versus 34) were increased and CD15 decreased (21.6 versus 28.3) when CD65 (6.6 versus 4.4), CD162 (21.3 versus 21.1) and CD11b (10.5 versus 12) were in the same range. Monocytes receptors CD64 (30.5 versus 16.6), CD11b (18.7 versus 9.8), and CD162 (38.6 versus 36.5) were increased and CD15 decreased (10.3 versus 17.9); CD65 were in the same range (2.3 versus 1.96).\n\nMonocytes and neutrophils are activated during severe COVID-19 infection as shown by strong upregulation of CD64. High monocyte and neutrophil CD64 can be an indicator of a severe form of COVID19. The adhesion molecules (CD11b, CD162, CD65, and CD15) are not upregulated on otherwise activated neutrophils, which might lead to relative impairment of tissue migration. Low adhesion profile of neutrophils suggests immune dysfunction of neutrophils. Monocytes maintain upregulation of some adhesion molecules (CD11b, CD162) suggesting the persistence of an increased ability to migrate into tissues, even during a severe stage of COVID-19. Future research should focus on CD64 and CD11b kinetics in the context of prognosis.", "doi": "10.1177/20499361211034065", "pmid": "34377464", "labels": {"Funder: VR": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pmc", "key": "PMC8326822"}, {"db": "pii", "key": "10.1177_20499361211034065"}], "notes": [], "created": "2021-08-12T17:04:26.909Z", "modified": "2023-06-19T14:59:17.671Z"}, {"entity": "publication", "iuid": "c588fa750a8444f6858a06bdaafe89cd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c588fa750a8444f6858a06bdaafe89cd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c588fa750a8444f6858a06bdaafe89cd"}}, "title": "Anti-Viral and Immunomodulatory Properties of Propolis: Chemical Diversity, Pharmacological Properties, Preclinical and Clinical Applications, and In Silico Potential against SARS-CoV-2.", "authors": [{"family": "Yosri", "given": "Nermeen", "initials": "N", "orcid": "0000-0002-5043-9690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4179b7f496234c44bfb86f42d793209f.json"}}, {"family": "Abd El-Wahed", "given": "Aida A", "initials": "AA", "orcid": "0000-0002-2200-3507", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4c6fbed70bba4ea79707d30822d774bd.json"}}, {"family": "Ghonaim", "given": "Reem", "initials": "R"}, {"family": "Khattab", "given": "Omar M", "initials": "OM"}, {"family": "Sabry", "given": "Aya", "initials": "A"}, {"family": "Ibrahim", "given": "Mahmoud A A", "initials": "MAA", "orcid": "0000-0003-4819-2040", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/552195f5616e456b82fd45359b56f9c7.json"}}, {"family": "Moustafa", "given": "Mahmoud F", "initials": "MF"}, {"family": "Guo", "given": "Zhiming", "initials": "Z", "orcid": "0000-0001-6416-7457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3be657eca2a84ef48613cd71b9a43222.json"}}, {"family": "Zou", "given": "Xiaobo", "initials": "X"}, {"family": "Algethami", "given": "Ahmed F M", "initials": "AFM"}, {"family": "Masry", "given": "Saad H D", "initials": "SHD"}, {"family": "AlAjmi", "given": "Mohamed F", "initials": "MF"}, {"family": "Afifi", "given": "Hanan S", "initials": "HS"}, {"family": "Khalifa", "given": "Shaden A M", "initials": "SAM"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}], "type": "journal article", "published": "2021-07-31", "journal": {"title": "Foods", "issn": "2304-8158", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "Propolis, a resin produced by honeybees, has long been used as a dietary supplement and folk remedy, and more recent preclinical investigations have demonstrated a large spectrum of potential therapeutic bioactivities, including antioxidant, antibacterial, anti-inflammatory, neuroprotective, immunomodulatory, anticancer, and antiviral properties. As an antiviral agent, propolis and various constituents have shown promising preclinical efficacy against adenoviruses, influenza viruses, respiratory tract viruses, herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), human immunodeficiency virus (HIV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Over 300 chemical components have been identified in propolis, including terpenes, flavonoids, and phenolic acids, with the specific constituent profile varying widely according to geographic origin and regional flora. Propolis and its constituents have demonstrated potential efficacy against SARS-CoV-2 by modulating multiple pathogenic and antiviral pathways. Molecular docking studies have demonstrated high binding affinities of propolis derivatives to multiple SARS-CoV-2 proteins, including 3C-like protease (3CLpro), papain-like protease (PLpro), RNA-dependent RNA polymerase (RdRp), the receptor-binding domain (RBD) of the spike protein (S-protein), and helicase (NSP13), as well as to the viral target angiotensin-converting enzyme 2 (ACE2). Among these compounds, retusapurpurin A has shown high affinity to 3CLpro (\u0394G = -9.4 kcal/mol), RdRp (-7.5), RBD (-7.2), NSP13 (-9.4), and ACE2 (-10.4) and potent inhibition of viral entry by forming hydrogen bonds with amino acid residues within viral and human target proteins. In addition, propolis-derived baccharin demonstrated even higher binding affinity towards PLpro (-8.2 kcal/mol). Measures of drug-likeness parameters, including metabolism, distribution, absorption, excretion, and toxicity (ADMET) characteristics, also support the potential of propolis as an effective agent to combat COVID-19.", "doi": "10.3390/foods10081776", "pmid": "34441553", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "foods10081776"}, {"db": "pmc", "key": "PMC8391193"}], "notes": [], "created": "2021-09-01T07:15:52.044Z", "modified": "2021-09-01T07:15:52.145Z"}, {"entity": "publication", "iuid": "199aec09cf01468a9111c3c31b8302eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/199aec09cf01468a9111c3c31b8302eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/199aec09cf01468a9111c3c31b8302eb"}}, "title": "Swedish Covid-19 Investigation for Future Insights - A Population Epidemiology Approach Using Register Linkage (SCIFI-PEARL).", "authors": [{"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Franz\u00e9n", "given": "Stefan", "initials": "S"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Vanfleteren", "given": "Lowie", "initials": "L", "orcid": "0000-0002-4387-4096", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bb5d1f761ef48c4837ed4f984717f0e.json"}}, {"family": "Hammar", "given": "Niklas", "initials": "N"}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d2c4588f000c470abf08f2e40852b6d1.json"}}, {"family": "Santosa", "given": "Ailiana", "initials": "A"}, {"family": "Bj\u00f6rck", "given": "Staffan", "initials": "S"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fe6d5e69164feeb20a7a5f3d2a5bbe.json"}}], "type": "journal article", "published": "2021-07-30", "journal": {"title": "CLEP", "issn": "1179-1349", "issn-l": null, "volume": "13", "issue": null, "pages": "649-659"}, "abstract": "In response to the Covid-19 pandemic, we designed and initiated a nationwide linked multi-register, regularly updated, observational study for timely response to urgent scientific questions.\r\n\r\nTo describe the SCIFI-PEARL (Swedish Covid-19 Investigation for Future Insights - a Population Epidemiology Approach using Register Linkage) linked database encompassing essentially all known diagnosed Swedish Covid-19 patients plus a large general population comparison cohort and outline its utility in the current and future phases of the pandemic.\r\n\r\nIndividuals with Covid-19 from the entire country are identified on a regularly updated basis, from different sources: all individuals from SmiNet, the national database of notifiable diseases, with positive SARS-CoV-2 polymerase chain reaction (PCR) test results; patients identified in the healthcare system by condition (ICD-10) or procedure codes in the National Patient Register or Cause-of-Death Register; patients identified through several disease-specific national quality registers (NQRs); and in two regions additionally patients identified in primary care. A comparison population was obtained by stratified random sampling from Swedish national population registers. Data from all these registers plus the National Prescribed Drug Register, the Cancer Register, national sociodemographic registers, some additional NQRs, the National Vaccination Register, and further data sources, are then linked to all study subjects (Covid-19 cases and population cohort). New cases in the study population and all data for all subjects are updated every few months, as required.\r\n\r\nThe SCIFI-PEARL study cohort captures Swedish residents with Covid-19 on an ongoing basis, includes a representative general population comparison cohort, and links to a broad range of national and regional healthcare data for a comprehensive longitudinal view of the Covid-19 pandemic. By combining high-quality national registers with short time delay and continuous repeated linkage and updating, the project brings timely and internationally relevant data for epidemiological research on SARS-CoV-2. Our efforts provide an example and important learnings for similar efforts internationally in the future.", "doi": "10.2147/CLEP.S312742", "pmid": "34354377", "labels": {"Research Area: Vaccine": null, "Category: Public Health": null, "Type: Journal article": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Funder: Hj\u00e4rt-Lungfonden": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "312742"}, {"db": "pmc", "key": "PMC8331198"}], "notes": [], "created": "2021-08-12T12:22:04.801Z", "modified": "2021-12-06T12:29:00.905Z"}, {"entity": "publication", "iuid": "89bcd628edf945e68aed0254ce19aa95", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/89bcd628edf945e68aed0254ce19aa95.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/89bcd628edf945e68aed0254ce19aa95"}}, "title": "Impact of the COVID-19 pandemic on nuclear medicine departments in Europe.", "authors": [{"family": "Moreira", "given": "Ana Paula", "initials": "AP", "orcid": "0000-0001-6873-6039", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5f3afab19af4ba3a538c1a387b69642.json"}}, {"family": "Jamar", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Ozcan", "given": "Zehra", "initials": "Z"}, {"family": "Piciu", "given": "Doina", "initials": "D"}, {"family": "Als", "given": "Claudine", "initials": "C"}, {"family": "Franceschi", "given": "Maja", "initials": "M"}, {"family": "Tr\u00e4g\u00e5rdh", "given": "Elin", "initials": "E"}, {"family": "Zagar", "given": "Ivana", "initials": "I"}, {"family": "Sowa-Staszczak", "given": "Anna", "initials": "A"}, {"family": "Cachin", "given": "Florent", "initials": "F"}, {"family": "Bennink", "given": "Roel", "initials": "R"}, {"family": "Forrer", "given": "Flavio", "initials": "F"}, {"family": "Adamsen", "given": "Tom Christian", "initials": "TC"}, {"family": "Fotopolous", "given": "Andreas", "initials": "A"}, {"family": "Kalnina", "given": "Marika", "initials": "M"}, {"family": "Jensen", "given": "Lars Thorbj\u00f8rn", "initials": "LT"}, {"family": "Mussalo", "given": "Hanna", "initials": "H"}, {"family": "Simanek", "given": "Milan", "initials": "M"}, {"family": "Garcia-Ca\u00f1amaque", "given": "Lina", "initials": "L"}, {"family": "Nazarenko", "given": "Sergei", "initials": "S"}, {"family": "Mihailovic", "given": "Jasna", "initials": "J"}, {"family": "Bar-Sever", "given": "Zvi", "initials": "Z"}, {"family": "O'Connell", "given": "Martin", "initials": "M"}, {"family": "Miladinova", "given": "Daniela", "initials": "D"}, {"family": "Graham", "given": "Richard", "initials": "R"}, {"family": "Giubbini", "given": "Raffaele", "initials": "R"}, {"family": "Kalisk\u00e1", "given": "Lucia", "initials": "L"}, {"family": "Rozi\u0107", "given": "Damir", "initials": "D"}, {"family": "Krause", "given": "Bernd J", "initials": "BJ"}, {"family": "Gallowitsch", "given": "Hans-J\u00fcrgen", "initials": "HJ"}, {"family": "Gy\u00f6rke", "given": "Tam\u00e1s", "initials": "T"}, {"family": "Sediene", "given": "Severina", "initials": "S"}, {"family": "Rumyantsev", "given": "Pavel", "initials": "P"}, {"family": "Wadsak", "given": "Wolfgang", "initials": "W"}, {"family": "Kunikowska", "given": "Jolanta", "initials": "J"}], "type": "editorial", "published": "2021-07-30", "journal": {"title": "Eur J Nucl Med Mol Imaging", "issn": "1619-7089", "issn-l": null}, "abstract": null, "doi": "10.1007/s00259-021-05484-z", "pmid": "34328532", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00259-021-05484-z"}, {"db": "pmc", "key": "PMC8322112"}], "notes": [], "created": "2021-08-04T17:03:29.051Z", "modified": "2021-08-04T17:03:29.091Z"}, {"entity": "publication", "iuid": "95872c856b0a43b89e3f3a8ebeb8a3f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95872c856b0a43b89e3f3a8ebeb8a3f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95872c856b0a43b89e3f3a8ebeb8a3f4"}}, "title": "Antimicrobial stewardship in the ICU in COVID times: the known unknowns.", "authors": [{"family": "Schouten", "given": "Jeroen", "initials": "J"}, {"family": "De Waele", "given": "Jan", "initials": "J"}, {"family": "Lanckohr", "given": "Christian", "initials": "C"}, {"family": "Koulenti", "given": "Despoina", "initials": "D"}, {"family": "Haddad", "given": "Nisrine", "initials": "N"}, {"family": "Rizk", "given": "Nesrine", "initials": "N"}, {"family": "Sj\u00f6vall", "given": "Fredrik", "initials": "F"}, {"family": "Kanj", "given": "Souha S", "initials": "SS"}], "type": "journal article", "published": "2021-07-30", "journal": {"title": "Int J Antimicrob Agents", "issn": "1872-7913", "issn-l": null, "volume": null, "issue": null, "pages": "106409"}, "abstract": "Since the start of the COVID-19 pandemic, there has been concern about the concomitant rise of antimicrobial resistance (AMR). While bacterial co-infections seem rare in COVID-19 patients admitted to hospital wards and ICUs, an increase in empirical antibiotic use has been described. In the ICU setting, where antibiotics are already abundantly -and often inappropriately- prescribed, the need for an ICU specific Antimicrobial Stewardship Program (ASP) is widely advocated. Apart from essentially warning against the use of antibacterial drugs for the treatment of a viral infection, other aspects of ICU antimicrobial stewardship need to be considered in view of the clinical course and characteristics of COVID-19. First, the distinction between infectious and non-infectious (inflammatory) causes of respiratory deterioration during ICU stay is difficult and the much-debated relevance of fungal and viral co-infections adds to the complexity of empirical antimicrobial prescribin. Biomarkers such as PCT for the decision to start antibacterial therapy for ICU nosocomial infections seem to be more promising in COVID-19 than in non-COVID-19 patients. In COVID-19 patients CMV reactivation is an important factor to consider when assessing patients infected with SARS-CoV-2 as it may have a role in modulating patient immune response. The diagnosis of COVID-19 associated Invasive Aspergillosis (CAPA) is challenging because of the lack of sensitivity and specificity of the available tests. Further, altered PK/PD properties need to be taken into account when prescribing antimicrobial therapy. Future research should now further explore the \"known unknowns\", ideally with robust prospective study designs.", "doi": "10.1016/j.ijantimicag.2021.106409", "pmid": "34339777", "labels": {"Type: Review": null, "Category: Public Health": null, "Category: Rehabilitation": null}, "xrefs": [{"db": "pii", "key": "S0924-8579(21)00181-3"}], "notes": [], "created": "2021-08-04T10:11:22.551Z", "modified": "2021-11-18T12:48:00.214Z"}, {"entity": "publication", "iuid": "448436ec26c24e71bc517a9bce6d8e45", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/448436ec26c24e71bc517a9bce6d8e45.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/448436ec26c24e71bc517a9bce6d8e45"}}, "title": "A look into the future of the COVID-19 pandemic in Europe: an expert consultation.", "authors": [{"family": "Iftekhar", "given": "Emil Nafis", "initials": "EN"}, {"family": "Priesemann", "given": "Viola", "initials": "V"}, {"family": "Balling", "given": "Rudi", "initials": "R"}, {"family": "Bauer", "given": "Simon", "initials": "S"}, {"family": "Beutels", "given": "Philippe", "initials": "P"}, {"family": "Calero Valdez", "given": "Andr\u00e9", "initials": "A"}, {"family": "Cuschieri", "given": "Sarah", "initials": "S"}, {"family": "Czypionka", "given": "Thomas", "initials": "T"}, {"family": "Dumpis", "given": "Uga", "initials": "U"}, {"family": "Glaab", "given": "Enrico", "initials": "E"}, {"family": "Grill", "given": "Eva", "initials": "E"}, {"family": "Hanson", "given": "Claudia", "initials": "C"}, {"family": "Hotulainen", "given": "Pirta", "initials": "P"}, {"family": "Klimek", "given": "Peter", "initials": "P"}, {"family": "Kretzschmar", "given": "Mirjam", "initials": "M"}, {"family": "Kr\u00fcger", "given": "Tyll", "initials": "T"}, {"family": "Krutzinna", "given": "Jenny", "initials": "J"}, {"family": "Low", "given": "Nicola", "initials": "N"}, {"family": "Machado", "given": "Helena", "initials": "H"}, {"family": "Martins", "given": "Carlos", "initials": "C"}, {"family": "McKee", "given": "Martin", "initials": "M"}, {"family": "Mohr", "given": "Sebastian Bernd", "initials": "SB"}, {"family": "Nassehi", "given": "Armin", "initials": "A"}, {"family": "Perc", "given": "Matja\u017e", "initials": "M"}, {"family": "Petelos", "given": "Elena", "initials": "E"}, {"family": "Pickersgill", "given": "Martyn", "initials": "M"}, {"family": "Prainsack", "given": "Barbara", "initials": "B"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}, {"family": "Schernhammer", "given": "Eva", "initials": "E"}, {"family": "Staines", "given": "Anthony", "initials": "A"}, {"family": "Szczurek", "given": "Ewa", "initials": "E"}, {"family": "Tsiodras", "given": "Sotirios", "initials": "S"}, {"family": "Van Gucht", "given": "Steven", "initials": "S"}, {"family": "Willeit", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2021-07-30", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "pages": "100185", "issn-l": null}, "abstract": "How will the coronavirus disease 2019 (COVID-19) pandemic develop in the coming months and years? Based on an expert survey, we examine key aspects that are likely to influence the COVID-19 pandemic in Europe. The challenges and developments will strongly depend on the progress of national and global vaccination programs, the emergence and spread of variants of concern (VOCs), and public responses to non-pharmaceutical interventions (NPIs). In the short term, many people remain unvaccinated, VOCs continue to emerge and spread, and mobility and population mixing are expected to increase. Therefore, lifting restrictions too much and too early risk another damaging wave. This challenge remains despite the reduced opportunities for transmission given vaccination progress and reduced indoor mixing in summer 2021. In autumn 2021, increased indoor activity might accelerate the spread again, whilst a necessary reintroduction of NPIs might be too slow. The incidence may strongly rise again, possibly filling intensive care units, if vaccination levels are not high enough. A moderate, adaptive level of NPIs will thus remain necessary. These epidemiological aspects combined with economic, social, and health-related consequences provide a more holistic perspective on the future of the COVID-19 pandemic.", "doi": "10.1016/j.lanepe.2021.100185", "pmid": "34345876", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00162-9"}, {"db": "pmc", "key": "PMC8321710"}], "notes": [], "created": "2021-08-06T09:46:00.472Z", "modified": "2021-08-06T09:46:00.483Z"}, {"entity": "publication", "iuid": "7864977a8d4f41e0adbbdf3e5152c4cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7864977a8d4f41e0adbbdf3e5152c4cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7864977a8d4f41e0adbbdf3e5152c4cf"}}, "title": "Understanding and Responding to the Impact of COVID-19 on Paediatric Gastroenterology Training & Practice of Young ESPGHAN Members.", "authors": [{"family": "Ni\u0163\u0103", "given": "Andreia F", "initials": "AF"}, {"family": "Tsita", "given": "Despina", "initials": "D"}, {"family": "Grima", "given": "Anne-Marie", "initials": "AM"}, {"family": "Cameron", "given": "Fiona", "initials": "F"}, {"family": "Rock", "given": "Nathalie M", "initials": "NM"}, {"family": "Tapsas", "given": "Dimitrios", "initials": "D"}], "type": "journal article", "published": "2021-07-29", "journal": {"title": "J Pediatr Gastroenterol Nutr", "issn": "1536-4801", "issn-l": null}, "abstract": "Limited data exist about the impact of the COVID-19 pandemic on the training and clinical practice of young doctors. The aim of this study was to evaluate the impact on paediatric gastroenterologists in training posts during the first wave of European COVID pandemic.\n\nAll Young ESPGHAN (YE) members received a multiple-choice questionnaire concerning the impact (if any) on their clinical practice, mental health, quality of care provided and fellowship/training experience. The survey was conducted between May 22nd, 2020 and June 10th, 2020.\n\nOf the 144 responders (40% of YE members), 85% (n = 123) reported an impact of COVID-19. 96% reported an impact on their clinical practice, including more virtual patient consultation (n = 91), underutilization of ambulatory care (n = 113) and reduced or lack of planned admissions (n = 75). Endoscopy restrictions to semi-urgent or emergency cases were reported in 82 and lack of medical equipment/drugs (n = 47) were also reported.Reported adverse mental health issues included poor concentration, increased stress levels, an impact on family life in 62% and a reduced quality of care in 45%; this was more often reported in doctors from Southern Europe (54%) than in those from other geographical areas.77% reported an impact on the content of their fellowship, including lack of participation in national/international meetings, withdrawn research time and limited mentoring.\n\nThe impact of the Covid-19 pandemic has been shown to affect the clinical practice, training and mental health of YE members. Adaptations of training programmes and targeted strategies to improve the clinical practice of young practitioners are needed and proposed in this manuscript.", "doi": "10.1097/MPG.0000000000003239", "pmid": "34269327", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00005176-900000000-95598"}], "notes": [], "created": "2021-08-06T07:16:08.125Z", "modified": "2021-08-06T07:16:08.151Z"}, {"entity": "publication", "iuid": "873495dc287a4506b7d1aad39e7087eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/873495dc287a4506b7d1aad39e7087eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/873495dc287a4506b7d1aad39e7087eb"}}, "title": "Topological network based drug repurposing for coronavirus 2019.", "authors": [{"family": "Habibi", "given": "Mahnaz", "initials": "M", "orcid": "0000-0002-8969-2706", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d44ce728e5d5412e8720941daae54a51.json"}}, {"family": "Taheri", "given": "Golnaz", "initials": "G"}], "type": "journal article", "published": "2021-07-29", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "7", "pages": "e0255270", "issn-l": "1932-6203"}, "abstract": "The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has become the current health concern and threat to the entire world. Thus, the world needs the fast recognition of appropriate drugs to restrict the spread of this disease. The global effort started to identify the best drug compounds to treat COVID-19, but going through a series of clinical trials and our lack of information about the details of the virus's performance has slowed down the time to reach this goal. In this work, we try to select the subset of human proteins as candidate sets that can bind to approved drugs. Our method is based on the information on human-virus protein interaction and their effect on the biological processes of the host cells. We also define some informative topological and statistical features for proteins in the protein-protein interaction network. We evaluate our selected sets with two groups of drugs. The first group contains the experimental unapproved treatments for COVID-19, and we show that from 17 drugs in this group, 15 drugs are approved by our selected sets. The second group contains the external clinical trials for COVID-19, and we show that 85% of drugs in this group, target at least one protein of our selected sets. We also study COVID-19 associated protein sets and identify proteins that are essential to disease pathology. For this analysis, we use DAVID tools to show and compare disease-associated genes that are contributed between the COVID-19 comorbidities. Our results for shared genes show significant enrichment for cardiovascular-related, hypertension, diabetes type 2, kidney-related and lung-related diseases. In the last part of this work, we recommend 56 potential effective drugs for further research and investigation for COVID-19 treatment. Materials and implementations are available at: https://github.com/MahnazHabibi/Drug-repurposing.", "doi": "10.1371/journal.pone.0255270", "pmid": "34324563", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-13445"}, {"db": "pmc", "key": "PMC8320924"}], "notes": [], "created": "2021-08-04T17:08:35.085Z", "modified": "2021-08-04T17:08:51.831Z"}, {"entity": "publication", "iuid": "d31bb5c7c6454cc9b62516cf7715a905", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d31bb5c7c6454cc9b62516cf7715a905.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d31bb5c7c6454cc9b62516cf7715a905"}}, "title": "JAK Inhibitors \u2014 More Than Just Glucocorticoids", "authors": [{"family": "Stebbing", "given": "Justin", "initials": "J", "orcid": "0000-0002-1117-6947", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/556a75be47ab4c48922a55999648d4e3.json"}}, {"family": "Lauschke", "given": "Volker M", "initials": "VM"}], "type": "journal-article", "published": "2021-07-29", "journal": {"title": "N Engl J Med", "issn": "1533-4406", "volume": "385", "issue": "5", "pages": "463-465", "issn-l": null}, "abstract": null, "doi": "10.1056/nejme2108667", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2021-08-24T12:51:20.585Z", "modified": "2021-08-24T12:51:20.621Z"}, {"entity": "publication", "iuid": "771c423765b6417f97e55e79bf243e7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/771c423765b6417f97e55e79bf243e7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/771c423765b6417f97e55e79bf243e7e"}}, "title": "Impact of SARS-CoV-2 on training and mental well-being of surgical gynecological oncology trainees.", "authors": [{"family": "Gaba", "given": "Faiza", "initials": "F", "orcid": "0000-0003-4081-6883", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b6c7f32259c64092ba285fa71706aab6.json"}}, {"family": "Blyuss", "given": "Oleg", "initials": "O"}, {"family": "Rodriguez", "given": "Isabel", "initials": "I"}, {"family": "Dilley", "given": "James", "initials": "J"}, {"family": "Wan", "given": "Yee-Loi Louise", "initials": "YL"}, {"family": "Saiz", "given": "Allison", "initials": "A"}, {"family": "Razumova", "given": "Zoia", "initials": "Z", "orcid": "0000-0001-6598-0896", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f9dd79d57f44a0ab455974d84356528.json"}}, {"family": "Zalewski", "given": "Kamil", "initials": "K"}, {"family": "Nikolova", "given": "Tanja", "initials": "T"}, {"family": "Selcuk", "given": "Ilker", "initials": "I"}, {"family": "Bizzarri", "given": "Nicol\u00f2", "initials": "N", "orcid": "0000-0002-1727-904X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e74a49b3221461d87f46384492b5b7f.json"}}, {"family": "Theofanakis", "given": "Charalampos", "initials": "C"}, {"family": "Lanner", "given": "Maximilian", "initials": "M"}, {"family": "Pletnev", "given": "Andrei", "initials": "A"}, {"family": "Gurumurthy", "given": "Mahalakshmi", "initials": "M"}, {"family": "Manchanda", "given": "Ranjit", "initials": "R", "orcid": "0000-0003-3381-5057", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/91c3585da7d84dc2b7a0788dbfdc78e2.json"}}], "type": "journal article", "published": "2021-07-29", "journal": {"title": "Int J Gynecol Cancer", "issn": "1525-1438", "issn-l": null}, "abstract": "The SARS-CoV-2 global pandemic has caused a crisis disrupting health systems worldwide. While efforts are being made to determine the extent of the disruption, the impact on gynecological oncology trainees/training has not been explored. We conducted an international survey of the impact of SARS-CoV-2 on clinical practice, medical education, and mental well-being of surgical gynecological oncology trainees.\n\nIn our cross-sectional study, a customized web-based survey was circulated to surgical gynecological oncology trainees from national/international organizations from May to November 2020. Validated questionnaires assessed mental well-being. The Wilcoxon rank-sum test and Fisher's exact test were used to analyse differences in means and proportions. Multiple linear regression was used to evaluate the effect of variables on psychological/mental well-being outcomes. Outcomes included clinical practice, medical education, anxiety and depression, distress, and mental well-being.\n\nA total of 127 trainees from 34 countries responded. Of these, 52% (66/127) were from countries with national training programs (UK/USA/Netherlands/Canada/Australia) and 48% (61/127) from countries with no national training programs. Altogether, 28% (35/125) had suspected/confirmed COVID-19, 28% (35/125) experienced a fall in household income, 20% (18/90) were self-isolated from households, 45% (57/126) had to re-use personal protective equipment, and 22% (28/126) purchased their own. In total, 32.3% (41/127) of trainees (16.6% (11/66) from countries with a national training program vs 49.1% (30/61) from countries with no national training program, p=0.02) perceived they would require additional time to complete their training fellowship. The additional training time anticipated did not differ between trainees from countries with or without national training programs (p=0.11) or trainees at the beginning or end of their fellowship (p=0.12). Surgical exposure was reduced for 50% of trainees. Departmental teaching continued throughout the pandemic for 69% (87/126) of trainees, although at reduced frequency for 16.1% (14/87), and virtually for 88.5% (77/87). Trainees reporting adequate pastoral support (defined as allocation of a dedicated mentor/access to occupational health support services) had better mental well-being with lower levels of anxiety/depression (p=0.02) and distress (p<0.001). Trainees from countries with a national training program experienced higher levels of distress (p=0.01). Mean (SD) pre-pandemic mental well-being scores were significantly higher than post-pandemic scores (8.3 (1.6) vs 7 (1.8); p<0.01).\n\nSARS-CoV-2 has negatively impacted the surgical training, household income, and psychological/mental well-being of surgical gynecological oncology trainees. The overall clinical impact was worse for trainees in countries with no national training program than for those in countries with a national training program, although national training program trainees reported greater distress. COVID-19 sickness increased anxiety/depression. The recovery phase must focus on improving mental well-being and addressing lost training opportunities.", "doi": "10.1136/ijgc-2021-002803", "pmid": "34326158", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijgc-2021-002803"}], "notes": [], "created": "2021-08-04T17:05:43.480Z", "modified": "2021-08-04T17:05:43.612Z"}, {"entity": "publication", "iuid": "fa473254c88e438882b511fa003724f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa473254c88e438882b511fa003724f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa473254c88e438882b511fa003724f0"}}, "title": "Comparing the First and Second Wave of COVID-19 in Kidney Transplant Recipients: An East-European Perspective.", "authors": [{"family": "Elec", "given": "Florin Ioan", "initials": "FI"}, {"family": "Bolboac\u0103", "given": "Sorana D", "initials": "SD"}, {"family": "Muntean", "given": "Adriana", "initials": "A"}, {"family": "Elec", "given": "Alina Daciana", "initials": "AD"}, {"family": "Cismaru", "given": "Cristina", "initials": "C"}, {"family": "Lup\u015fe", "given": "Mihaela", "initials": "M"}, {"family": "Oltean", "given": "Mihai", "initials": "M"}], "type": "journal article", "published": "2021-07-29", "journal": {"title": "Eur Surg Res", "issn": "1421-9921", "pages": "1-8", "issn-l": null}, "abstract": "The present study examined whether patient characteristics, management, and outcome of kidney transplant recipients (KTx) with COVID-19 changed in the second versus the first pandemic wave.\n\nWe reviewed all available data (demographics, medical history, comorbidities, therapeutic interventions, and outcome) on our KTx with COVID-19 during the first wave (March-September 2020, n = 33) and the second wave (October 2020-February 2021, n = 149) of the COVID-19 pandemic.\n\nOne hundred eighty-two out of our 1,503 KTx in active follow-up got COVID-19 during 12-month period, corresponding to a prevalence of 12.1%. No difference was found in age, gender distribution, comorbidities, body mass index, or baseline immunosuppression between the 2 COVID-19 waves. Bilateral COVID pneumonia was more frequent during the first wave. More KTx were managed as outpatients during the second wave (15 vs. 39%, p < 0.01). Calcineurin inhibitors were more sparingly reduced during the second wave, whereas antimetabolites were similarly reduced (91 vs. 86, p = ns). Admission to intensive care units was comparable between the first (27%) and second waves (23%). During the first wave, 8 out of 9 patients (89%) requiring intensive care died, whereas the mortality of the ICU patients in the second wave was 68% (23 deaths) (p = 0.2). The overall mortality was 24% during the first wave and 16% during the second wave (p = 0.21), while in-hospital mortality was identical between the CO-VID-19 waves (27%). Increasing age and poor allograft function were significant predictors of mortality.\n\nMost patient characteristics and outcome were comparable between the first 2 COVID-19 waves. More KTx were managed as outpatients without an overall negative impact on outcome.", "doi": "10.1159/000517559", "pmid": "34325432", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "000517559"}], "notes": [], "created": "2021-08-04T17:06:31.650Z", "modified": "2021-08-04T17:06:31.673Z"}, {"entity": "publication", "iuid": "b509475ceaa74df8b64815bc18f6d147", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b509475ceaa74df8b64815bc18f6d147.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b509475ceaa74df8b64815bc18f6d147"}}, "title": "Body mass index and Mini Nutritional Assessment-Short Form as predictors of in-geriatric hospital mortality in older adults with COVID-19.", "authors": [{"family": "Kananen", "given": "L", "initials": "L"}, {"family": "Eriksdotter", "given": "M", "initials": "M"}, {"family": "Bostr\u00f6m", "given": "A M", "initials": "AM"}, {"family": "Kivipelto", "given": "M", "initials": "M"}, {"family": "Annetorp", "given": "M", "initials": "M"}, {"family": "Metzner", "given": "C", "initials": "C"}, {"family": "B\u00e4ck Jerlardtz", "given": "V", "initials": "V"}, {"family": "Engstr\u00f6m", "given": "M", "initials": "M"}, {"family": "Johnson", "given": "P", "initials": "P"}, {"family": "Lundberg", "given": "L G", "initials": "LG"}, {"family": "\u00c5kesson", "given": "E", "initials": "E"}, {"family": "S\u00fchl \u00d6berg", "given": "C", "initials": "C"}, {"family": "H\u00e4gg", "given": "S", "initials": "S"}, {"family": "Religa", "given": "D", "initials": "D"}, {"family": "Jylh\u00e4v\u00e4", "given": "J", "initials": "J"}, {"family": "Cederholm", "given": "T", "initials": "T"}], "type": "journal article", "published": "2021-07-29", "journal": {"title": "Clin Nutr", "issn": "1532-1983", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Overweight and obesity have been consistently reported to carry an increased risk for poorer outcomes in coronavirus disease 2019 (COVID-19) in adults. Existing reports mainly focus on in-hospital and intensive care unit mortality in patient cohorts usually not representative of the population with the highest mortality, i.e. the very old and frail patients. Accordingly, little is known about the risk patterns related to body mass and nutrition in very old patients. Our aim was to assess the relationship between body mass index (BMI), nutritional status and in-geriatric hospital mortality among geriatric patients treated for COVID-19. As a reference, the analyses were performed also in patients treated for other diagnoses than COVID-19.\r\n\r\nWe analyzed up to 10,031 geriatric patients with a median age of 83 years of which 1409 (14%) were hospitalized for COVID-19 and 8622 (86%) for other diagnoses in seven geriatric hospitals in the Stockholm region, Sweden during March 2020-January 2021. Data were available in electronic hospital records. The associations between 1) BMI and 2) nutritional status, assessed using the Mini-Nutritional Assessment - Short Form (MNA-SF) scale, and short-term in-geriatric hospital mortality were analyzed using logistic regression.\r\n\r\nAfter adjusting for age, sex, comorbidity, polypharmacy, frailty and the wave of the pandemic (first vs. second), underweight defined as BMI<18.5 increased the risk of in-hospital mortality in COVID-19 patients (odds ratio [OR] = 2.30; confidence interval [CI] = 1.17-4.31). Overweight and obesity were not associated with in-hospital mortality. Malnutrition; i.e. MNA-SF 0-7 points, increased the risk of in-hospital mortality in patients treated for COVID-19 (OR = 2.03; CI = 1.16-3.68) and other causes (OR = 6.01; CI = 2.73-15.91).\r\n\r\nOur results indicate that obesity is not a risk factor for very old patients with COVID-19, but emphasize the role of underweight and malnutrition for in-hospital mortality in geriatric patients with COVID-19.", "doi": "10.1016/j.clnu.2021.07.025", "pmid": "34389208", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S0261-5614(21)00360-5"}], "notes": [], "created": "2021-08-16T09:26:21.338Z", "modified": "2021-08-25T14:35:56.646Z"}, {"entity": "publication", "iuid": "2bb6cb4f6e9b41fd8ef541d2b6f39a10", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2bb6cb4f6e9b41fd8ef541d2b6f39a10.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2bb6cb4f6e9b41fd8ef541d2b6f39a10"}}, "title": "Artificial Intelligence for Hospital Health Care: Application Cases and Answers to Challenges in European Hospitals.", "authors": [{"family": "Klumpp", "given": "Matthias", "initials": "M", "orcid": "0000-0002-7543-2751", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15df94e4fcab4a0db6c1d14583233d27.json"}}, {"family": "Hintze", "given": "Marcus", "initials": "M"}, {"family": "Immonen", "given": "Milla", "initials": "M"}, {"family": "R\u00f3denas-Rigla", "given": "Francisco", "initials": "F", "orcid": "0000-0003-3264-4735", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0038ea81bcec424e9af333117f5e677d.json"}}, {"family": "Pilati", "given": "Francesco", "initials": "F"}, {"family": "Aparicio-Mart\u00ednez", "given": "Fernando", "initials": "F"}, {"family": "\u00c7elebi", "given": "Dilay", "initials": "D", "orcid": "0000-0002-7103-3868", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/367982752bd54431aa5bdec8f6492ffe.json"}}, {"family": "Liebig", "given": "Thomas", "initials": "T", "orcid": "0000-0002-9841-1101", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14a857c22bbd49cea833f737f7635f42.json"}}, {"family": "Jirstrand", "given": "Mats", "initials": "M"}, {"family": "Urbann", "given": "Oliver", "initials": "O"}, {"family": "Hedman", "given": "Marja", "initials": "M", "orcid": "0000-0003-1318-8287", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5bf03be491024743b39ff1f0a8ba1fbe.json"}}, {"family": "Lipponen", "given": "Jukka A", "initials": "JA"}, {"family": "Bicciato", "given": "Silvio", "initials": "S", "orcid": "0000-0002-1944-7078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/284edb100a1f46bb83a0a404bbf7ba5b.json"}}, {"family": "Radan", "given": "Anda-Petronela", "initials": "AP", "orcid": "0000-0003-0113-2761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f75f9ec5a49f45189aca88d7f525d10a.json"}}, {"family": "Valdivieso", "given": "Bernardo", "initials": "B"}, {"family": "Thronicke", "given": "Wolfgang", "initials": "W"}, {"family": "Gunopulos", "given": "Dimitrios", "initials": "D"}, {"family": "Delgado-Gonzalo", "given": "Ricard", "initials": "R"}], "type": "journal article", "published": "2021-07-29", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "volume": "9", "issue": "8", "issn-l": null}, "abstract": "The development and implementation of artificial intelligence (AI) applications in health care contexts is a concurrent research and management question. Especially for hospitals, the expectations regarding improved efficiency and effectiveness by the introduction of novel AI applications are huge. However, experiences with real-life AI use cases are still scarce. As a first step towards structuring and comparing such experiences, this paper is presenting a comparative approach from nine European hospitals and eleven different use cases with possible application areas and benefits of hospital AI technologies. This is structured as a current review and opinion article from a diverse range of researchers and health care professionals. This contributes to important improvement options also for pandemic crises challenges, e.g., the current COVID-19 situation. The expected advantages as well as challenges regarding data protection, privacy, or human acceptance are reported. Altogether, the diversity of application cases is a core characteristic of AI applications in hospitals, and this requires a specific approach for successful implementation in the health care sector. This can include specialized solutions for hospitals regarding human-computer interaction, data management, and communication in AI implementation projects.", "doi": "10.3390/healthcare9080961", "pmid": "34442098", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "healthcare9080961"}, {"db": "pmc", "key": "PMC8393951"}], "notes": [], "created": "2021-09-01T07:15:14.462Z", "modified": "2021-09-01T07:15:14.633Z"}, {"entity": "publication", "iuid": "2ab52f4459a74cbd88570d67b152abcd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ab52f4459a74cbd88570d67b152abcd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ab52f4459a74cbd88570d67b152abcd"}}, "title": "Why women choose at-home abortion via teleconsultation in France: drivers of telemedicine abortion during and beyond the COVID-19 pandemic.", "authors": [{"family": "Atay", "given": "Hazal", "initials": "H", "orcid": "0000-0002-1634-6060", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/135c2f41c76e45a991573192b054aa03.json"}}, {"family": "Perivier", "given": "Helene", "initials": "H"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}, {"family": "Guilleminot", "given": "Jean", "initials": "J"}, {"family": "Hassoun", "given": "Danielle", "initials": "D"}, {"family": "Hottois", "given": "Judith", "initials": "J"}, {"family": "Gomperts", "given": "Rebecca", "initials": "R"}, {"family": "Levrier", "given": "Emmanuelle", "initials": "E"}], "type": "journal article", "published": "2021-07-28", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-2009", "issn-l": "2515-1991"}, "abstract": "In an attempt to understand the demand and main drivers of telemedicine abortion, we analysed the requests that Women on Web (WoW), an online telemedicine abortion service operating worldwide, received from France throughout 2020.\n\nWe conducted a parallel, convergent, mixed-methods study among 809 consultations received from France at WoW between 1 January and 31 December 2020. We performed a cross-sectional study of data obtained from the WoW consultation survey and a manifest content analysis of anonymised email correspondence of 140 women consulting with the WoW helpdesk from France.\n\nWe found that women encounter macro-level, individual-level and provider-level constraints while trying to access abortion in France. The preferences and needs over secrecy (n=356, 46.2%), privacy (n=295, 38.3%) and comfort (n=269, 34.9%) are among the most frequent reasons for women from France to choose telemedicine abortion through WoW. The COVID-19 pandemic seems to be an important driver for resorting to telemedicine (n=236, 30.6%). The lockdowns had a significant impact on the number of consultations received at WoW from France, increasing from 60 in March to 128 in April during the first lockdown and from 54 in October to 80 in November during the second lockdown.\n\nThe demand for at-home medical abortion via teleconsultation increased in France during the lockdowns. However, drivers of telemedicine abortion are multidimensional and go beyond the conditions unique to the pandemic.", "doi": "10.1136/bmjsrh-2021-201176", "pmid": "34321255", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjsrh-2021-201176"}], "notes": [], "created": "2021-08-04T17:09:36.988Z", "modified": "2021-08-04T17:09:37.026Z"}, {"entity": "publication", "iuid": "4de11e08768e477eb00fa08e3d787692", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4de11e08768e477eb00fa08e3d787692.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4de11e08768e477eb00fa08e3d787692"}}, "title": "SARS-CoV-2 Spike Protein Extrapolation for COVID Diagnosis and Vaccine Development.", "authors": [{"family": "Malik", "given": "Yashpal S", "initials": "YS"}, {"family": "Kumar", "given": "Prashant", "initials": "P"}, {"family": "Ansari", "given": "Mohd Ikram", "initials": "MI"}, {"family": "Hemida", "given": "Maged G", "initials": "MG"}, {"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME"}, {"family": "Abdel-Moneim", "given": "Ahmed S", "initials": "AS"}, {"family": "Ganesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Salajegheh", "given": "Sina", "initials": "S"}, {"family": "Natesan", "given": "Senthilkumar", "initials": "S"}, {"family": "Sircar", "given": "Shubhankar", "initials": "S"}, {"family": "Safdar", "given": "Muhammad", "initials": "M"}, {"family": "Vinodhkumar", "given": "O R", "initials": "OR"}, {"family": "Duarte", "given": "Phelipe M", "initials": "PM"}, {"family": "Patel", "given": "Shailesh K", "initials": "SK"}, {"family": "Klein", "given": "J\u00f6rn", "initials": "J"}, {"family": "Rahimi", "given": "Parastoo", "initials": "P"}, {"family": "Dhama", "given": "Kuldeep", "initials": "K"}], "type": "journal article", "published": "2021-07-28", "journal": {"title": "Front. Mol. Biosci.", "issn": "2296-889X", "volume": "8", "pages": "607886", "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to coronavirus disease 2019 (COVID-19) pandemic affecting nearly 71.2 million humans in more than 191 countries, with more than 1.6 million mortalities as of 12 December, 2020. The spike glycoprotein (S-protein), anchored onto the virus envelope, is the trimer of S-protein comprised of S1 and S2 domains which interacts with host cell receptors and facilitates virus-cell membrane fusion. The S1 domain comprises of a receptor binding domain (RBD) possessing an N-terminal domain and two subdomains (SD1 and SD2). Certain regions of S-protein of SARS-CoV-2 such as S2 domain and fragment of the RBD remain conserved despite the high selection pressure. These conserved regions of the S-protein are extrapolated as the potential target for developing molecular diagnostic techniques. Further, the S-protein acts as an antigenic target for different serological assay platforms for the diagnosis of COVID-19. Virus-specific IgM and IgG antibodies can be used to detect viral proteins in ELISA and lateral flow immunoassays. The S-protein of SARS-CoV-2 has very high sequence similarity to SARS-CoV-1, and the monoclonal antibodies (mAbs) against SARS-CoV-1 cross-react with S-protein of SARS-CoV-2 and neutralize its activity. Furthermore, in vitro studies have demonstrated that polyclonal antibodies targeted against the RBD of S-protein of SARS-CoV-1 can neutralize SARS-CoV-2 thus inhibiting its infectivity in permissive cell lines. Research on coronaviral S-proteins paves the way for the development of vaccines that may prevent SARS-CoV-2 infection and alleviate the current global coronavirus pandemic. However, specific neutralizing mAbs against SARS-CoV-2 are in clinical development. Therefore, neutralizing antibodies targeting SARS-CoV-2 S-protein are promising specific antiviral therapeutics for pre-and post-exposure prophylaxis and treatment of SARS-CoV-2 infection. We hereby review the approaches taken by researchers across the world to use spike gene and S-glycoprotein for the development of effective diagnostics, vaccines and therapeutics against SARA-CoV-2 infection the COVID-19 pandemic.", "doi": "10.3389/fmolb.2021.607886", "pmid": "34395515", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8355592"}], "notes": [], "created": "2021-08-17T06:42:35.226Z", "modified": "2021-08-17T06:42:35.238Z"}, {"entity": "publication", "iuid": "5b83a052d34a4d6c8974f2c1df4b38e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5b83a052d34a4d6c8974f2c1df4b38e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5b83a052d34a4d6c8974f2c1df4b38e8"}}, "title": "High-flow nasal oxygen (HFNO) for patients with Covid-19 outside intensive care units.", "authors": [{"family": "Issa", "given": "Issa", "initials": "I"}, {"family": "S\u00f6derberg", "given": "M\u00e5rten", "initials": "M"}], "type": "journal article", "published": "2021-07-28", "journal": {"title": "Respir Med", "issn": "1532-3064", "volume": "187", "pages": "106554", "issn-l": "0954-6111"}, "abstract": "High-flow nasal oxygen (HFNO) has traditionally only been used in intensive care units (ICU) especially in acute respiratory distress syndrome (ARDS).\n\nWe studied the use of HFNO at S\u00f6dersjukhuset, Stockholm, in patients with moderate to severe ARDS related to Covid-19 as well as its benefits both for patients and to offload the ICU. The patients were observed with frequent controls to assess the need of ICU in case of deterioration.\n\nWe studied 41 patients with HFNO treatment either as primarily treatment (Step-Up) or after stabilizing in the ICU (Step-Down). The average duration for treatment with HFNO was 5.6 days. Of these patients 55% were discharged home or to geriatric rehabilitation and 10% avoided ICU completely. The usage of HFNO saved in total 229 days in the ICU. Mortality was higher among elderly patients, and patients with comorbidities (mainly hypertension and obesity).\n\nHFNO treatment is feasible and efficient for patients with Covid-19, saving resources in the ICU and offering additional advantages as waken proning and fewer complications compared to traditional ICU care. It requires however frequent controls as deterioration is recurrent.", "doi": "10.1016/j.rmed.2021.106554", "pmid": "34340173", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0954-6111(21)00260-2"}], "notes": [], "created": "2021-08-04T10:10:08.771Z", "modified": "2021-08-04T10:10:08.782Z"}, {"entity": "publication", "iuid": "90f29222ad714723bbd9ced04cad354e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90f29222ad714723bbd9ced04cad354e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90f29222ad714723bbd9ced04cad354e"}}, "title": "Risk perception, treatment adherence, and personality during COVID-19 pandemic: An international study on cancer patients.", "authors": [{"family": "Cheli", "given": "Simone", "initials": "S", "orcid": "0000-0002-0432-3769", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d454912b2b7463e9f09b0c32954570f.json"}}, {"family": "Lam", "given": "Wendy W T", "initials": "WWT", "orcid": "0000-0003-2383-0149", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72b193d3e93e4db0b1b69bcf36e8199e.json"}}, {"family": "Estap\u00e9", "given": "Tania", "initials": "T", "orcid": "0000-0001-9792-2586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28a910dd36ee4e51947763acf49bd12b.json"}}, {"family": "Winterling", "given": "Jeanette", "initials": "J", "orcid": "0000-0003-4165-9015", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/334f6c0ee8d047b88231d04d2b148e45.json"}}, {"family": "Bahcivan", "given": "Ozan", "initials": "O"}, {"family": "Andritsch", "given": "Elisabeth", "initials": "E"}, {"family": "Weis", "given": "Joachim", "initials": "J", "orcid": "0000-0002-8646-6607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/38e0112be6eb448f821b51aab7e439d3.json"}}, {"family": "Centeno", "given": "Isabel", "initials": "I"}, {"family": "Serpentini", "given": "Samantha", "initials": "S", "orcid": "0000-0002-0517-3416", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/731e1839e02544c38db8553cab833149.json"}}, {"family": "Farkas", "given": "Clemens", "initials": "C"}, {"family": "Wengstr\u00f6m", "given": "Yvonne", "initials": "Y"}, {"family": "Fioretto", "given": "Luisa", "initials": "L"}, {"family": "Baider", "given": "Lea", "initials": "L"}, {"family": "Lam", "given": "Cherry C L", "initials": "CCL"}, {"family": "Goldzweig", "given": "Gil", "initials": "G", "orcid": "0000-0003-2295-1627", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5adb0c7e08ff46938308ba55a450ddee.json"}}], "type": "journal article", "published": "2021-07-27", "journal": {"title": "Psychooncology", "issn": "1099-1611", "issn-l": null}, "abstract": "To explore the role of personality traits in moderating the relation between COVID-19 risk perception and treatment adherence, and between risk perception and psychosocial distress in patients diagnosed with cancer.\n\nAn online survey (n = 1281) was conducted worldwide in seven countries (Austria, Germany, Hong Kong, Italy, Spain, Sweden, and Turkey). Inclusion criteria were to be 18 years of age or older, have received a cancer diagnosis, and be in treatment or follow-up. A few moderated regression models were performed with both personality traits and Hierarchical Taxonomy of Psychopathology super-spectra as moderators.\n\nDetachment, negative affectivity, psychoticism and all the super-spectra significantly moderated the relation between coronavirus risk perception and psychosocial distress, after the adjusting effect of confidence in safeguards. Only negative affectivity moderated the association between coronavirus risk perception and treatment adherence.\n\nPersonality traits may foster the understanding of how a patient might adjust to cancer treatment and, more generically, to highly stressful events such as the COVID-19 pandemic. Further research is needed to confirm the results in different cancer stages and types.", "doi": "10.1002/pon.5775", "pmid": "34314560", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-05T06:49:17.670Z", "modified": "2021-08-05T06:49:56.380Z"}, {"entity": "publication", "iuid": "874dc3a385944b54abd448b449c42852", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/874dc3a385944b54abd448b449c42852.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/874dc3a385944b54abd448b449c42852"}}, "title": "Insomnia episodes, new-onset pharmacological treatments and other sleep disturbances during the COVID-19 pandemic: a nationwide cross-sectional study in Brazilian health care professionals.", "authors": [{"family": "Drager", "given": "Luciano F", "initials": "LF"}, {"family": "Pachito", "given": "Daniela V", "initials": "DV"}, {"family": "Moreno", "given": "Claudia R C", "initials": "CRC"}, {"family": "Tavares", "given": "Almir R", "initials": "AR"}, {"family": "Conway", "given": "Silvia G", "initials": "SG"}, {"family": "Assis", "given": "M\u00e1rcia", "initials": "M"}, {"family": "Sguillar", "given": "Danilo A", "initials": "DA"}, {"family": "Moreira", "given": "Gustavo A", "initials": "GA"}, {"family": "Bacelar", "given": "Andrea", "initials": "A"}, {"family": "Genta", "given": "Pedro R", "initials": "PR"}], "type": "journal article", "published": "2021-07-27", "journal": {"title": "J Clin Sleep Med", "issn": "1550-9397", "issn-l": null}, "abstract": "To evaluate the impact of COVID-19 pandemic on insomnia and other sleep disturbances in health care professionals.\n\nA survey was distributed using social media and organizational emails to Brazilian active health care professionals during the COVID-19 outbreak. We explored potential associated factors including age, gender, occupation, workplace, work hours, income, previous infection with COVID-19, recent/current contact with COVID-19 patients, regional number of incident deaths, anxiety, and burnout. We evaluated new-onset/ previous insomnia worsening episodes (primary outcome), new pharmacological treatments, sleep quality, duration, nightmares and snoring (secondary outcomes).\n\nA total of 4,384 health professionals from all regions of the country were included in the analysis (44\u00b112 years, 76% females, 53.8% physicians). Overall, 55.7% were assisting patients with COVID-19, and 9.2% had a previous COVID-19 infection. The primary outcome occurred in 32.9% of respondents in parallel to 13% new pharmacological treatments for insomnia. The sleep quality worsened for 61.4%, while 43.5% and 22.8% reported \u22651-hour sleep duration reduction and worsening or new-onset nightmares, respectively. Multivariate analyses showed that age (OR:1.008; 95% CI 1.001-1.015), females (OR:1.590; 95% CI 1.335-1.900), weight change (decrease: OR:1.772; 95% CI 1.453-2.161; increase: OR:1.468; 95% CI 1.249-1.728), prevalent anxiety (OR:3.414; 95% CI 2.954-3.948), new-onset burnout (OR:1.761; 95% CI 1.489-2.083), family income reduction >30% (OR:1.288; 95% CI 1.069-1.553) and assisting patients with COVID-19 (OR:1.275; 95% CI 1.081-1.506) were independently associated with new-onset or worsening of previous insomnia episodes.\n\nWe observed a huge burden of insomnia episodes and other sleep disturbances in health care professionals during the COVID-19 pandemic.", "doi": "10.5664/jcsm.9570", "pmid": "34314346", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-05T06:50:22.198Z", "modified": "2021-11-18T12:41:20.850Z"}, {"entity": "publication", "iuid": "6c0622945cb14014a699e3ce3788c348", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c0622945cb14014a699e3ce3788c348.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c0622945cb14014a699e3ce3788c348"}}, "title": "Impact of tiered restrictions on human activities and the epidemiology of the second wave of COVID-19 in Italy.", "authors": [{"family": "Manica", "given": "Mattia", "initials": "M", "orcid": "0000-0003-3709-1199", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f1dee2cd796464983ca73416f1ba644.json"}}, {"family": "Guzzetta", "given": "Giorgio", "initials": "G"}, {"family": "Riccardo", "given": "Flavia", "initials": "F", "orcid": "0000-0002-1582-6329", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db383a5731dd4bb1aa8ff4c1cac91455.json"}}, {"family": "Valenti", "given": "Antonio", "initials": "A"}, {"family": "Poletti", "given": "Piero", "initials": "P", "orcid": "0000-0001-5453-5199", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e47d12a6b4954f45b9cf7c10f53aea19.json"}}, {"family": "Marziano", "given": "Valentina", "initials": "V", "orcid": "0000-0003-2842-7906", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9548ac3b58a249708f9ad8a835f42794.json"}}, {"family": "Trentini", "given": "Filippo", "initials": "F", "orcid": "0000-0001-6915-7282", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1ef47385a014489af492240312faded.json"}}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A", "orcid": "0000-0002-0480-8723", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96fca74501fd40f59359426781336b42.json"}}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Vescio", "given": "Maria Fenicia", "initials": "MF", "orcid": "0000-0002-3285-919X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fb4525bc8684390b022335a044b9db8.json"}}, {"family": "Spuri", "given": "Matteo", "initials": "M"}, {"family": "Petrone", "given": "Daniele", "initials": "D"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Iavicoli", "given": "Sergio", "initials": "S"}, {"family": "Ajelli", "given": "Marco", "initials": "M", "orcid": "0000-0003-1753-4749", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e1711c9d1c04770b118631d74173efd.json"}}, {"family": "Brusaferro", "given": "Silvio", "initials": "S"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P", "orcid": "0000-0002-0805-2927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/95cf0a950b334a61a4420f778420d114.json"}}, {"family": "Merler", "given": "Stefano", "initials": "S", "orcid": "0000-0002-5117-0611", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/380ed711c37a41e49c4b4f53ab0636af.json"}}], "type": "journal article", "published": "2021-07-27", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "4570", "issn-l": "2041-1723"}, "abstract": "To counter the second COVID-19 wave in autumn 2020, the Italian government introduced a system of physical distancing measures organized in progressively restrictive tiers (coded as yellow, orange, and red) imposed on a regional basis according to real-time epidemiological risk assessments. We leverage the data from the Italian COVID-19 integrated surveillance system and publicly available mobility data to evaluate the impact of the three-tiered regional restriction system on human activities, SARS-CoV-2 transmissibility and hospitalization burden in Italy. The individuals' attendance to locations outside the residential settings was progressively reduced with tiers, but less than during the national lockdown against the first COVID-19 wave in the spring. The reproduction number R(t) decreased below the epidemic threshold in 85 out of 107 provinces after the introduction of the tier system, reaching average values of about 0.95-1.02 in the yellow tier, 0.80-0.93 in the orange tier and 0.74-0.83 in the red tier. We estimate that the reduced transmissibility resulted in averting about 36% of the hospitalizations between November 6 and November 25, 2020. These results are instrumental to inform public health efforts aimed at preventing future resurgence of cases.", "doi": "10.1038/s41467-021-24832-z", "pmid": "34315899", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-24832-z"}, {"db": "pmc", "key": "PMC8316570"}, {"db": "URL", "key": "https://doi.org/10.6084/m9.figshare.14153351.v1", "description": "Mobility and epidemiological data"}], "notes": [], "created": "2021-08-05T06:48:17.298Z", "modified": "2021-11-18T12:40:09.354Z"}, {"entity": "publication", "iuid": "e6060ed659914e25af19d827947cbde6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6060ed659914e25af19d827947cbde6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6060ed659914e25af19d827947cbde6"}}, "title": "Emergence of an early SARS-CoV-2 epidemic in the United States.", "authors": [{"family": "Zeller", "given": "Mark", "initials": "M"}, {"family": "Gangavarapu", "given": "Karthik", "initials": "K"}, {"family": "Anderson", "given": "Catelyn", "initials": "C"}, {"family": "Smither", "given": "Allison R", "initials": "AR"}, {"family": "Vanchiere", "given": "John A", "initials": "JA"}, {"family": "Rose", "given": "Rebecca", "initials": "R"}, {"family": "Snyder", "given": "Daniel J", "initials": "DJ"}, {"family": "Dudas", "given": "Gytis", "initials": "G"}, {"family": "Watts", "given": "Alexander", "initials": "A"}, {"family": "Matteson", "given": "Nathaniel L", "initials": "NL"}, {"family": "Robles-Sikisaka", "given": "Refugio", "initials": "R"}, {"family": "Marshall", "given": "Maximilian", "initials": "M"}, {"family": "Feehan", "given": "Amy K", "initials": "AK"}, {"family": "Sabino-Santos", "given": "Gilberto", "initials": "G"}, {"family": "Bell-Kareem", "given": "Antoinette R", "initials": "AR"}, {"family": "Hughes", "given": "Laura D", "initials": "LD"}, {"family": "Alkuzweny", "given": "Manar", "initials": "M"}, {"family": "Snarski", "given": "Patricia", "initials": "P"}, {"family": "Garcia-Diaz", "given": "Julia", "initials": "J"}, {"family": "Scott", "given": "Rona S", "initials": "RS"}, {"family": "Melnik", "given": "Lilia I", "initials": "LI"}, {"family": "Klitting", "given": "Rapha\u00eblle", "initials": "R"}, {"family": "McGraw", "given": "Michelle", "initials": "M"}, {"family": "Belda-Ferre", "given": "Pedro", "initials": "P"}, {"family": "DeHoff", "given": "Peter", "initials": "P"}, {"family": "Sathe", "given": "Shashank", "initials": "S"}, {"family": "Marotz", "given": "Clarisse", "initials": "C"}, {"family": "Grubaugh", "given": "Nathan D", "initials": "ND"}, {"family": "Nolan", "given": "David J", "initials": "DJ"}, {"family": "Drouin", "given": "Arnaud C", "initials": "AC"}, {"family": "Genemaras", "given": "Kaylynn J", "initials": "KJ"}, {"family": "Chao", "given": "Karissa", "initials": "K"}, {"family": "Topol", "given": "Sarah", "initials": "S"}, {"family": "Spencer", "given": "Emily", "initials": "E"}, {"family": "Nicholson", "given": "Laura", "initials": "L"}, {"family": "Aigner", "given": "Stefan", "initials": "S"}, {"family": "Yeo", "given": "Gene W", "initials": "GW"}, {"family": "Farnaes", "given": "Lauge", "initials": "L"}, {"family": "Hobbs", "given": "Charlotte A", "initials": "CA"}, {"family": "Laurent", "given": "Louise C", "initials": "LC"}, {"family": "Knight", "given": "Rob", "initials": "R"}, {"family": "Hodcroft", "given": "Emma B", "initials": "EB"}, {"family": "Khan", "given": "Kamran", "initials": "K"}, {"family": "Fusco", "given": "Dahlene N", "initials": "DN"}, {"family": "Cooper", "given": "Vaughn S", "initials": "VS"}, {"family": "Lemey", "given": "Phillipe", "initials": "P"}, {"family": "Gardner", "given": "Lauren", "initials": "L"}, {"family": "Lamers", "given": "Susanna L", "initials": "SL"}, {"family": "Kamil", "given": "Jeremy P", "initials": "JP"}, {"family": "Garry", "given": "Robert F", "initials": "RF"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Andersen", "given": "Kristian G", "initials": "KG"}], "type": "journal article", "published": "2021-07-27", "journal": {"title": "Cell", "issn": "1097-4172", "issn-l": "0092-8674"}, "abstract": "The emergence of the COVID-19 epidemic in the United States (U.S.) went largely undetected due to inadequate testing. New Orleans experienced one of the earliest and fastest accelerating outbreaks, coinciding with Mardi Gras. To gain insight into the emergence of SARS-CoV-2 in the U.S. and how large-scale events accelerate transmission, we sequenced SARS-CoV-2 genomes during the first wave of the COVID-19 epidemic in Louisiana. We show that SARS-CoV-2 in Louisiana had limited diversity compared to other U.S. states and that one introduction of SARS-CoV-2 led to almost all of the early transmission in Louisiana. By analyzing mobility and genomic data, we show that SARS-CoV-2 was already present in New Orleans before Mardi Gras, and the festival dramatically accelerated transmission. Our study provides an understanding of how superspreading during large-scale events played a key role during the early outbreak in the U.S. and can greatly accelerate epidemics.", "doi": "10.1016/j.cell.2021.07.030", "pmid": "34508652", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "S0092-8674(21)00889-8"}], "notes": [], "created": "2021-09-13T06:27:48.982Z", "modified": "2021-09-13T06:28:12.476Z"}, {"entity": "publication", "iuid": "744226cc5c5144879e5767e369df749d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/744226cc5c5144879e5767e369df749d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/744226cc5c5144879e5767e369df749d"}}, "title": "Publisher Correction: A SARS-CoV-2 (COVID-19) biological network to find targets for drug repurposing.", "authors": [{"family": "Habibi", "given": "Mahnaz", "initials": "M"}, {"family": "Taheri", "given": "Golnaz", "initials": "G"}, {"family": "Aghdam", "given": "Rosa", "initials": "R"}], "type": "published erratum", "published": "2021-07-26", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "15550", "issn-l": "2045-2322"}, "abstract": null, "doi": "10.1038/s41598-021-94440-w", "pmid": "34312434", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-94440-w"}, {"db": "pmc", "key": "PMC8312203"}], "notes": [], "created": "2021-08-05T06:51:19.646Z", "modified": "2021-08-05T06:51:32.486Z"}, {"entity": "publication", "iuid": "26ad1c470c1947dd88ed132b5289fe00", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26ad1c470c1947dd88ed132b5289fe00.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26ad1c470c1947dd88ed132b5289fe00"}}, "title": "Gambling-Like Day Trading During the COVID-19 Pandemic \u2013 Need for Research on a Pandemic-Related Risk of Indebtedness and Mental Health Impact", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "Fern\u00e1ndez-Aranda", "given": "Fernando", "initials": "F"}, {"family": "Jim\u00e9nez-Murcia", "given": "Susana", "initials": "S"}], "type": "journal-article", "published": "2021-07-26", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "issn-l": "1664-0640"}, "abstract": null, "doi": "10.3389/fpsyt.2021.715946", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-12T17:08:51.507Z", "modified": "2021-08-12T17:08:51.518Z"}, {"entity": "publication", "iuid": "be66ed79c9a94526a346fadd6606bbda", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be66ed79c9a94526a346fadd6606bbda.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be66ed79c9a94526a346fadd6606bbda"}}, "title": "Echocardiographic characterisation in critical Covid19 - an observational study", "authors": [{"family": "Isackson", "given": "Henrik", "initials": "H"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Flachskampf", "given": "Frank A", "initials": "FA"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}], "type": "posted-content", "published": "2021-07-26", "journal": {"title": "MedRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.07.23.21261025", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [], "notes": [], "created": "2021-08-03T11:38:30.872Z", "modified": "2022-02-09T10:24:26.569Z"}, {"entity": "publication", "iuid": "52a5191b1d05485fbf2afe5aa5526c84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/52a5191b1d05485fbf2afe5aa5526c84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/52a5191b1d05485fbf2afe5aa5526c84"}}, "title": "Detection and viral RNA shedding of SARS-CoV-2 in respiratory specimens relative to symptom onset among COVID-19 patients in Bavaria, Germany - Addendum.", "authors": [{"family": "Woudenberg", "given": "Tom", "initials": "T"}, {"family": "Eberle", "given": "Ute", "initials": "U"}, {"family": "Marosevic", "given": "Durdica", "initials": "D"}, {"family": "Liebl", "given": "Bernhard", "initials": "B"}, {"family": "Ackermann", "given": "Nikolaus", "initials": "N"}, {"family": "Katz", "given": "Katharina", "initials": "K"}, {"family": "Sing", "given": "Andreas", "initials": "A"}, {"family": "Bavarian SARS-CoV-2-Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-07-26", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": "149", "pages": "e167", "issn-l": null}, "abstract": null, "doi": "10.1017/S095026882100159X", "pmid": "34308806", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8314188"}, {"db": "pii", "key": "S095026882100159X"}], "notes": [], "created": "2021-08-05T06:52:32.877Z", "modified": "2023-06-19T15:23:43.663Z"}, {"entity": "publication", "iuid": "510a4bcdc52d4274b4982a084c7413ed", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/510a4bcdc52d4274b4982a084c7413ed.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/510a4bcdc52d4274b4982a084c7413ed"}}, "title": "Depressive symptoms and perception of risk during the first wave of the COVID-19 pandemic: A web-based cross-country comparative survey.", "authors": [{"family": "Terraneo", "given": "Marco", "initials": "M", "orcid": "0000-0003-1072-2923", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8940f795351451582749a735ac7d10e.json"}}, {"family": "Lombi", "given": "Linda", "initials": "L"}, {"family": "Bradby", "given": "Hannah", "initials": "H", "orcid": "0000-0002-0664-1170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6650bd723f06404cb9f068d9bda13541.json"}}], "type": "journal article", "published": "2021-07-26", "journal": {"title": "Sociol Health Illn", "issn": "1467-9566", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Evidence is accumulating of the negative impact of the COVID-19 pandemic and related public health measures on mental health. In this emergent field, there has been little research into the role of risk perception on depressive symptoms and the contribution of health-care resources to model risk perception and mental health. The aim of this paper is to describe the relationship between individual-level perception of risk and depression, controlling for a set of confounders and for country-level heterogeneity. A cross-sectional and observational online survey was conducted using a non-probability snowball sampling technique. We use data on 11,340 respondents, living in six European countries (Italy, Sweden, United Kingdom, France, Poland, Czech Republic) who completed survey questionnaires during the first months of the pandemic. We used a fixed-effect approach, which included individual and macro-level variables. The findings suggest that a high proportion of people suffering from depression and heightened risk perception is positively associated with reporting depressive symptoms, even if this relationship varies significantly between countries. Moreover, the association is moderated by contextual factors including health-care expenditure as a percentage of Gross Domestic Product, hospital beds for acute care, and number of medical specialists per head of population. Investment in health care offers a concrete means of protecting the mental health of a population living under pandemic restrictions.", "doi": "10.1111/1467-9566.13350", "pmid": "34309032", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-05T06:52:12.792Z", "modified": "2021-11-18T12:06:01.508Z"}, {"entity": "publication", "iuid": "9f1ffdda0e594d7d91e8fb212c9f63a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f1ffdda0e594d7d91e8fb212c9f63a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f1ffdda0e594d7d91e8fb212c9f63a0"}}, "title": "Conditions and strategies to meet the challenges imposed by the COVID-19-related visiting restrictions in the intensive care unit: A Scandinavian cross-sectional study.", "authors": [{"family": "Jensen", "given": "Hanne Irene", "initials": "HI"}, {"family": "\u00c5kerman", "given": "Eva", "initials": "E"}, {"family": "Lind", "given": "Ranveig", "initials": "R"}, {"family": "Alfheim", "given": "Hanne Birgit", "initials": "HB"}, {"family": "Frivold", "given": "Gro", "initials": "G"}, {"family": "Fridh", "given": "Isabell", "initials": "I"}, {"family": "\u00c5g\u00e5rd", "given": "Anne Sophie", "initials": "AS"}], "type": "journal article", "published": "2021-07-26", "journal": {"title": "Intensive Crit Care Nurs", "issn": "1532-4036", "issn-l": null, "volume": null, "issue": null, "pages": "103116"}, "abstract": "To examine conditions and strategies to meet the challenges imposed by the coronavirus disease 2019 (COVID-19)-related visiting restrictions in Scandinavian intensive care units.\r\n\r\nA cross-sectional survey.\r\n\r\nAdult intensive care units in Denmark, Norway and Sweden.\r\n\r\nLikert scale responses and free-text comments within six areas: capacity and staffing, visiting policies and access to the unit, information and conferences with relatives, written information, children as relatives and follow-up initiatives.\r\n\r\nThe overall response rate was 53% (74/140 participating units). All intensive care units had planned for capacity extensions; the majority ranging between 11 and 30 extra beds. From March-June 2020, units had a mean maximum of 9.4 COVID-19 patients simultaneously. Allowing restricted visiting was more common in Denmark (52%) and Norway (61%) than in Sweden where visiting was mostly denied except for dying patients (68%), due to a particular increased number of COVID-19 patients. The restrictions forced nurses to compromise on their usual standards of family care. Numerous models for maintaining contact between relatives and patients were described.\r\n\r\nVisitation restrictions compromised the quality of family care and entailed dilemmas for healthcare professionals but also spurred initiatives to developing new ways of providing family care.", "doi": "10.1016/j.iccn.2021.103116", "pmid": "34391628", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0964-3397(21)00105-1"}], "notes": [], "created": "2021-08-16T09:32:10.498Z", "modified": "2021-11-18T11:59:47.254Z"}, {"entity": "publication", "iuid": "1ccaf39e6fd54c4282412ead18d1c405", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ccaf39e6fd54c4282412ead18d1c405.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ccaf39e6fd54c4282412ead18d1c405"}}, "title": "Recurrent and persistent infection with SARS-CoV-2 - epidemiological data and case reports from Western Sweden, 2020.", "authors": [{"family": "Ringlander", "given": "Johan", "initials": "J", "orcid": "0000-0002-8483-6504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64f85af7dceb436498422e62f1a98c89.json"}}, {"family": "Olausson", "given": "Josefin", "initials": "J"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "H\u00e4rnqvist", "given": "Tor", "initials": "T"}, {"family": "Jakobsson", "given": "Hedvig E", "initials": "HE"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-07-24", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": null, "issue": null, "pages": "1-8"}, "abstract": "Reinfections with SARS-CoV-2 have been reported and most cases were classified as mild. Reports of persistent infection with SARS-CoV-2 are rare.\r\n\r\nTo investigate the frequency of recurrent and persistent infection with SARS-CoV-2.\r\n\r\nPossible cases of reinfection and persistent infection were retrospectively identified in a database of 59,998 patients. Deep sequencing of SARS-CoV-2 genomes was performed.\r\n\r\nWe report the first case of COVID-19 reinfection in Sweden and three cases of infection with persistence over several months. The rate of sequencing-verified reinfection was 0.02% (one patient out of 6014 patients testing positive during the period).\r\n\r\nThe reinfected patient had mild symptoms during the second episode, which might reflect partial immunity. The frequency of reinfection during the first wave of the pandemic in western Sweden was very low. Our results indicate that elderly with a putative reinfection more likely have persistent COVID-19.", "doi": "10.1080/23744235.2021.1957143", "pmid": "34308755", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "URL", "key": "https://www.tandfonline.com/doi/figure/10.1080/23744235.2021.1957143?scroll=top&needAccess=true", "description": "Nucleotide differences between the first infection and second infection strains from one patient with reinfection"}], "notes": [], "created": "2021-08-05T06:52:53.774Z", "modified": "2021-11-18T11:56:46.277Z"}, {"entity": "publication", "iuid": "d585588f3a9c4c0aac93cdf21af3264f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d585588f3a9c4c0aac93cdf21af3264f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d585588f3a9c4c0aac93cdf21af3264f"}}, "title": "Profiling lockdown adherence and poor coping responses towards the COVID-19 crisis in an international cross-sectional survey", "authors": [{"family": "Van Belle", "given": "Sylvia", "initials": "S", "orcid": "0000-0002-6247-5832", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bffd346b0f96471e9b815246904378e8.json"}}, {"family": "Dahl\u00e9n", "given": "Amelia", "initials": "A"}, {"family": "Schi\u00f6th", "given": "Helgi B", "initials": "HB", "orcid": "0000-0001-7112-0921", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ec43532c42c4ee5b79a470fede7d088.json"}}, {"family": "Brooks", "given": "Samantha J", "initials": "SJ", "orcid": "0000-0002-9146-6257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef6c03915d334cd3bbefbe6508397561.json"}}], "type": "posted-content", "published": "2021-07-24", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.07.21.21260910", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-08-03T11:41:30.941Z", "modified": "2021-11-19T11:26:33.994Z"}, {"entity": "publication", "iuid": "e97f8e5f6fd241c2bdd9c2ae9b51e552", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e97f8e5f6fd241c2bdd9c2ae9b51e552.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e97f8e5f6fd241c2bdd9c2ae9b51e552"}}, "title": "Pandemic backsliding: Violations of democratic standards during Covid-19.", "authors": [{"family": "Edgell", "given": "Amanda B", "initials": "AB"}, {"family": "Lachapelle", "given": "Jean", "initials": "J"}, {"family": "L\u00fchrmann", "given": "Anna", "initials": "A"}, {"family": "Maerz", "given": "Seraphine F", "initials": "SF"}], "type": "journal article", "published": "2021-07-24", "journal": {"title": "Soc Sci Med", "issn": "1873-5347", "issn-l": null, "volume": "285", "issue": null, "pages": "114244"}, "abstract": "The widespread adoption of emergency powers during Covid-19 raises important questions about what constitutes a (un)democratic response to crises. While the institutions and practices of democracy during normal times are well established, democratic standards during emergencies have yet to be conceptualized in the literature. This makes it difficult to systematically answer questions like - How do states' responses to Covid-19 violate democratic standards? Do such violations make states' responses more effective? Drawing on international treaties, norms, and academic scholarship, we propose a novel conceptualization of democratic standards for emergency measures. We then identify which government responses to Covid-19 qualify as a violation of democratic standards within the framework of illiberal and authoritarian practices, introducing a dataset covering 144 countries from March 2020 onward. In this article, we provide an overview of the extent to which states violated democratic standards in their response to Covid-19 during 2020. We find no relationship between violations of democratic standards and reported Covid-19 mortality. Illiberal and authoritarian practices in response to the Covid-19 pandemic do not correlate with better public health outcomes. Rather, such crisis-driven violations should be carefully observed as they could signal autocratization.", "doi": "10.1016/j.socscimed.2021.114244", "pmid": "34399291", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0277-9536(21)00576-1"}], "notes": [], "created": "2021-08-17T06:41:22.807Z", "modified": "2022-11-23T08:54:57.436Z"}, {"entity": "publication", "iuid": "9b812d6e85c049a1a63606067812fe0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b812d6e85c049a1a63606067812fe0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b812d6e85c049a1a63606067812fe0e"}}, "title": "Federated Semi-Supervised Multi-Task Learning to Detect COVID-19 and Lungs Segmentation Marking Using Chest Radiography Images and Raspberry Pi Devices: An Internet of Medical Things Application.", "authors": [{"family": "Alam", "given": "Mahbub Ul", "initials": "MU", "orcid": "0000-0002-1101-3793", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d29bbd8d865401b8d0ef481eb80d6e2.json"}}, {"family": "Rahmani", "given": "Rahim", "initials": "R", "orcid": "0000-0001-5924-5457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bf1ae3967524119a9b97042d8ef16b3.json"}}], "type": "journal article", "published": "2021-07-24", "journal": {"title": "Sensors (Basel)", "issn": "1424-8220", "volume": "21", "issue": "15", "issn-l": null}, "abstract": "Internet of Medical Things (IoMT) provides an excellent opportunity to investigate better automatic medical decision support tools with the effective integration of various medical equipment and associated data. This study explores two such medical decision-making tasks, namely COVID-19 detection and lung area segmentation detection, using chest radiography images. We also explore different cutting-edge machine learning techniques, such as federated learning, semi-supervised learning, transfer learning, and multi-task learning to explore the issue. To analyze the applicability of computationally less capable edge devices in the IoMT system, we report the results using Raspberry Pi devices as accuracy, precision, recall, Fscore for COVID-19 detection, and average dice score for lung segmentation detection tasks. We also publish the results obtained through server-centric simulation for comparison. The results show that Raspberry Pi-centric devices provide better performance in lung segmentation detection, and server-centric experiments provide better results in COVID-19 detection. We also discuss the IoMT application-centric settings, utilizing medical data and decision support systems, and posit that such a system could benefit all the stakeholders in the IoMT domain.", "doi": "10.3390/s21155025", "pmid": "34372262", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "s21155025"}], "notes": [], "created": "2021-08-11T14:33:34.731Z", "modified": "2021-08-11T14:33:34.806Z"}, {"entity": "publication", "iuid": "44ae53d507a24f2ba8d79d4ca1bf93da", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44ae53d507a24f2ba8d79d4ca1bf93da.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44ae53d507a24f2ba8d79d4ca1bf93da"}}, "title": "Depression, anxiety and stress among Swedish university students during the second and third waves of COVID-19: A cohort study.", "authors": [{"family": "Johansson", "given": "Fred", "initials": "F", "orcid": "0000-0001-9717-0935", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e23a51cd8dc4d1da5032559b08fddd9.json"}}, {"family": "C\u00f4t\u00e9", "given": "Pierre", "initials": "P"}, {"family": "Hogg-Johnson", "given": "Sheilah", "initials": "S"}, {"family": "Skillgate", "given": "Eva", "initials": "E"}], "type": "journal article", "published": "2021-07-24", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": null, "issue": null, "pages": "14034948211031402"}, "abstract": "This study aims to describe the mean trajectories of depression, anxiety and stress symptoms among Swedish university students before and during the second and third waves of the COVID-19 pandemic.\r\n\r\nWe recruited 1835 participants in September 2020, of whom 81% provided follow-ups in December 2020-January 2021 and 77% provided follow-ups in March-April 2021. The short-form Depression, Anxiety and Stress Scale was used to measure mental health symptoms. Generalized estimating equations were used to estimate the mean differences in symptom levels over the three time periods.\r\n\r\nCompared with September, mean depression was 0.91 points of 21 higher (95% confidence interval (CI) 0.70-1.13) in December 2020-January 2021 and 0.66 points higher (95% CI 0.43-.88) in March-April 2021. Anxiety levels were 0.20 points higher (95% CI 0.05-0.34) in December 2020-January 2021 and 0.17 points higher (95% CI 0.02-0.33) in March-April 2021. Stress levels were 0.21 points higher (95% CI 0.00-0.41) in December 2020-January 2021 and 0.16 points lower (95% CI -0.38 to 0.05) in March-April 2021.\r\n\r\nOur results indicate relatively stable levels of mental health among Swedish university students during the second and third waves of COVID-19 compared with before the second wave. Mean depression symptom scores increased slightly, but the importance of this small increase is uncertain.", "doi": "10.1177/14034948211031402", "pmid": "34304621", "labels": {"Category: Public Health": null, "Type: Journal article": null, "Funder: Forte": null}, "xrefs": [], "notes": [], "created": "2021-08-05T07:01:57.155Z", "modified": "2021-11-18T11:46:25.237Z"}, {"entity": "publication", "iuid": "d1af80ca7b0e42858a06cf240412367a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1af80ca7b0e42858a06cf240412367a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1af80ca7b0e42858a06cf240412367a"}}, "title": "[High correlation between the different measures suggests that mortality is relatively correctly reported in Sweden].", "authors": [{"family": "Kalischer Wellander", "given": "Benjamin", "initials": "B"}, {"family": "L\u00f6tvall", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2021-07-23", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "volume": "118", "issn-l": "0023-7205"}, "abstract": "Infection fatality ratio (IFR) in covid-19 is highly debated in international and Swedish press. In Sweden, three different estimates have been used to estimate mortality, based on statistics either from the Swedish National Board of Health and Welfare, and the Public Health Agency of Sweden, whereas excess mortality calculated by EuroMOMO. Mortality is based on death certificates, which can be accurate or erroneous, but previous analyses have suggested that over- and underdiagnosis usually even out. EuroMOMO on the other hand reports all-cause mortality compared to an estimated baseline. In view of high correlation between the different measures, we suggest that mortality is relatively correctly reported in Sweden. We discuss IFR internationally and in Sweden, and suggest that IFR in the Western world is approximately 0.5-1%. However, these numbers will change over time depending on immunity induced by vaccination efforts, but also the potential spread of new virus variants.", "doi": null, "pmid": "34296754", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "21120"}], "notes": [], "created": "2021-08-05T07:09:48.985Z", "modified": "2021-08-05T07:09:49.008Z"}, {"entity": "publication", "iuid": "a3c910a0c23c46f9bd74172c2e64a432", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3c910a0c23c46f9bd74172c2e64a432.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3c910a0c23c46f9bd74172c2e64a432"}}, "title": "The geography of COVID-19 in Sweden.", "authors": [{"family": "Florida", "given": "Richard", "initials": "R"}, {"family": "Mellander", "given": "Charlotta", "initials": "C", "orcid": "0000-0002-4560-1905", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f4c34f7743b40df8673efcf78c039fc.json"}}], "type": "journal article", "published": "2021-07-23", "journal": {"title": "Ann Reg Sci", "issn": "0570-1864", "pages": "1-26", "issn-l": null}, "abstract": "This paper examines the geographic factors that are associated with the spread of COVID-19 during the first wave in Sweden. We focus particularly on the role of place-based factors versus factors associated with the spread or diffusion of COVID-19 across places. Sweden is a useful case study to examine the interplay of these factors because it did not impose mandatory lockdowns and because there were essentially no regional differences in the pandemic policies or strategies during the first wave of COVID-19. We examine the role of place-based factors like density, age structures and different socioeconomic factors on the geographic variation of COVID-19 cases and on deaths, across both municipalities and neighborhoods. Our findings show that factors associated with diffusion matter more than place-based factors in the geographic incidence of COVID-19 in Sweden. The most significant factor of all is proximity to places with higher levels of infections. COVID-19 is also higher in places that were hit earliest in the outbreak. Of place-based factors, the geographic variation in COVID-19 is most significantly related to the presence of high-risk nursing homes, and only modestly associated with factors like density, population size, income and other socioeconomic characteristics of places.", "doi": "10.1007/s00168-021-01071-0", "pmid": "34316091", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "1071"}, {"db": "pmc", "key": "PMC8299438"}], "notes": [], "created": "2021-08-05T06:47:37.298Z", "modified": "2021-08-05T06:47:37.351Z"}, {"entity": "publication", "iuid": "a5388cc81d2f4c0288d874cf43668310", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a5388cc81d2f4c0288d874cf43668310.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a5388cc81d2f4c0288d874cf43668310"}}, "title": "Housing, sanitation and living conditions affecting SARS-CoV-2 prevention interventions in 54 African countries.", "authors": [{"family": "Brewer", "given": "Timothy F", "initials": "TF", "orcid": "0000-0002-5615-1639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6e0f3db6e834dc3b13f7bb5920f588c.json"}}, {"family": "Zhang", "given": "Mary", "initials": "M", "orcid": "0000-0003-2534-3811", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a481992f82c74686845a5043cad02382.json"}}, {"family": "Gordon", "given": "David", "initials": "D"}, {"family": "Chung", "given": "Roger Yat-Nork", "initials": "RY"}, {"family": "Dejene", "given": "Negussie", "initials": "N"}, {"family": "Fonta", "given": "Cynthia L", "initials": "CL"}, {"family": "Grieve", "given": "Tigist", "initials": "T"}, {"family": "Haller\u00f6d", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Harris", "given": "Richard", "initials": "R"}, {"family": "Lanau", "given": "Alba", "initials": "A", "orcid": "0000-0001-6226-8545", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/da7a6d18caf847e3b424c6dbfd87640b.json"}}, {"family": "Leibbrandt", "given": "Murray", "initials": "M"}, {"family": "Mekonen", "given": "Yehualashet", "initials": "Y"}, {"family": "Muguni", "given": "Bongai", "initials": "B"}, {"family": "Najera", "given": "Hector", "initials": "H"}, {"family": "Nandy", "given": "Shailen", "initials": "S"}, {"family": "Heymann", "given": "S Jody", "initials": "SJ"}], "type": "journal article", "published": "2021-07-23", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": "149", "pages": "e183", "issn-l": null}, "abstract": "The feasibility of non-pharmacological public health interventions (NPIs) such as physical distancing or isolation at home to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in low-resource countries is unknown. Household survey data from 54 African countries were used to investigate the feasibility of SARS-CoV-2 NPIs in low-resource settings. Across the 54 countries, approximately 718 million people lived in households with \u2a7e6 individuals at home (median percentage of at-risk households 56% (95% confidence interval (CI), 51% to 60%)). Approximately 283 million people lived in households where \u2a7e3 people slept in a single room (median percentage of at-risk households 15% (95% CI, 13% to 19%)). An estimated 890 million Africans lack on-site water (71% (95% CI, 62% to 80%)), while 700 million people lacked in-home soap/washing facilities (56% (95% CI, 42% to 73%)). The median percentage of people without a refrigerator in the home was 79% (95% CI, 67% to 88%), while 45% (95% CI, 39% to 52%) shared toilet facilities with other households. Individuals in low-resource settings have substantial obstacles to implementing NPIs for mitigating SARS-CoV-2 transmission. These populations urgently need to be prioritised for coronavirus disease 2019 vaccination to prevent disease and to contain the global pandemic.", "doi": "10.1017/S0950268821001734", "pmid": "35852445", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0950268821001734"}, {"db": "pmc", "key": "PMC8367861"}], "notes": [], "created": "2022-08-12T08:50:35.543Z", "modified": "2022-08-12T08:51:09.009Z"}, {"entity": "publication", "iuid": "1bab0821eb174292b14bebc89e264da4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1bab0821eb174292b14bebc89e264da4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1bab0821eb174292b14bebc89e264da4"}}, "title": "Hofbauer cells and coronavirus disease 2019 (COVID-19) in pregnancy: Molecular pathology analysis of villous macrophages, endothelial cells, and placental findings from 22 placentas infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with and without fetal transmission.", "authors": [{"family": "Schwartz", "given": "David A", "initials": "DA"}, {"family": "Baldewijns", "given": "Marcella", "initials": "M"}, {"family": "Benachi", "given": "Alexandra", "initials": "A"}, {"family": "Bugatti", "given": "Mattia", "initials": "M"}, {"family": "Bulfamante", "given": "Gaetano", "initials": "G"}, {"family": "Cheng", "given": "Ke", "initials": "K"}, {"family": "Collins", "given": "Rebecca R J", "initials": "RRJ"}, {"family": "Debelenko", "given": "Larisa", "initials": "L"}, {"family": "De Luca", "given": "Dani\u00e8le", "initials": "D"}, {"family": "Facchetti", "given": "Fabio", "initials": "F"}, {"family": "Fitzgerald", "given": "Brendan", "initials": "B"}, {"family": "Levitan", "given": "Daniel", "initials": "D"}, {"family": "Linn", "given": "Rebecca L", "initials": "RL"}, {"family": "Marcelis", "given": "Lukas", "initials": "L"}, {"family": "Morotti", "given": "Denise", "initials": "D"}, {"family": "Morotti", "given": "Raffaella", "initials": "R"}, {"family": "Patan\u00e8", "given": "Luisa", "initials": "L"}, {"family": "Prevot", "given": "Sophie", "initials": "S"}, {"family": "Pulinx", "given": "Bianca", "initials": "B"}, {"family": "Saad", "given": "Ali G", "initials": "AG"}, {"family": "Schoenmakers", "given": "Sam", "initials": "S"}, {"family": "Strybol", "given": "David", "initials": "D"}, {"family": "Thomas", "given": "Kristen", "initials": "K"}, {"family": "Tosi", "given": "Delfina", "initials": "D"}, {"family": "Toto", "given": "Valentina", "initials": "V"}, {"family": "van der Meeren", "given": "Lotte E", "initials": "LE"}, {"family": "Verdijk", "given": "Robert M", "initials": "RM"}, {"family": "Vivanti", "given": "Alexandre J", "initials": "AJ"}, {"family": "Zaigham", "given": "Mehreen", "initials": "M"}], "type": "journal article", "published": "2021-07-23", "journal": {"title": "Arch Pathol Lab Med", "issn": "1543-2165", "issn-l": null}, "abstract": "- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can undergo maternal-fetal transmission, heightening interest in the placental pathology findings from this infection. Transplacental SARS-CoV-2 transmission is typically accompanied by chronic histiocytic intervillositis together with necrosis and positivity of syncytiotrophoblast for SARSCoV-2. Hofbauer cells are placental macrophages that have been involved in viral diseases including HIV and Zika virus, but their involvement in SARS-CoV-2 in unknown.\n\n- To determine whether SARS-CoV-2 can extend beyond the syncytiotrophoblast to enter Hofbauer cells, endothelium and other villous stromal cells in infected placentas of liveborn and stillborn infants.\n\n- Case-based retrospective analysis by 29 perinatal and molecular pathology specialists of placental findings from a preselected cohort of 22 SARS-CoV-2-infected placentas delivered to pregnant women testing positive for SARS-CoV-2 from 7 countries. Molecular pathology methods were used to investigate viral involvement of Hofbauer cells, villous capillary endothelium, syncytiotrophoblast and other fetal-derived cells.\n\n- Chronic histiocytic intervillositis and trophoblast necrosis was present in all 22 placentas (100%). SARS-CoV-2 was identified in Hofbauer cells from 4/22 placentas (18%). Villous capillary endothelial staining was positive in 2/22 cases (9%), both of which also had viral positivity in Hofbauer cells. Syncytiotrophoblast staining occurred in 21/22 placentas (95%). Hofbauer cell hyperplasia was present in 3/22 placentas (14%). In the 7 cases having documented transplacental infection of the fetus, 2 occurred in placentas with Hofbauer cell staining positive for SARS-CoV-2.\n\n- SARS-CoV-2 can extend beyond the trophoblast into the villous stroma, involving Hofbauer cells and capillary endothelial cells, in a small number of infected placentas. Most cases of SARS-CoV-2 transplacental fetal infection occur without Hofbauer cell involvement.", "doi": "10.5858/arpa.2021-0296-SA", "pmid": "34297794", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "468285"}], "notes": [], "created": "2021-08-05T07:09:11.883Z", "modified": "2021-08-05T07:09:11.909Z"}, {"entity": "publication", "iuid": "c38cd02818614d4db2930bfdc6e6e978", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c38cd02818614d4db2930bfdc6e6e978.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c38cd02818614d4db2930bfdc6e6e978"}}, "title": "COVID-19 in patients with CLL: improved survival outcomes and update on management strategies.", "authors": [{"family": "Roeker", "given": "Lindsey Elizabeth", "initials": "LE", "orcid": "0000-0002-3806-059X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d78144759e5240fda88869040bbb3405.json"}}, {"family": "Eyre", "given": "Toby Andrew", "initials": "TA", "orcid": "0000-0002-6631-9749", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d824fbb04d640d1b07bd88c1a09051c.json"}}, {"family": "Thompson", "given": "Meghan C", "initials": "MC"}, {"family": "Lamanna", "given": "Nicole", "initials": "N"}, {"family": "Coltoff", "given": "Alexander", "initials": "A"}, {"family": "Davids", "given": "Matthew S", "initials": "MS"}, {"family": "Baker", "given": "Peter", "initials": "P"}, {"family": "Leslie", "given": "Lori A", "initials": "LA"}, {"family": "Rogers", "given": "Kerry A", "initials": "KA", "orcid": "0000-0001-5748-7874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7dca0a2b81624be29144cc75eee2fe3f.json"}}, {"family": "Allan", "given": "John N", "initials": "JN", "orcid": "0000-0002-2088-0899", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f6a405964541f09452612c83538d89.json"}}, {"family": "Cordoba", "given": "Raul", "initials": "R", "orcid": "0000-0002-7654-8836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/14e78d427a5a42c4aa2f063439846f7b.json"}}, {"family": "Lopez-Garcia", "given": "Alberto", "initials": "A", "orcid": "0000-0002-5354-5261", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c785356a67e4cbb9835fe9ce04a6153.json"}}, {"family": "Antic", "given": "Darko", "initials": "D"}, {"family": "Pagel", "given": "John M", "initials": "JM"}, {"family": "Martinez-Calle", "given": "Nicol\u00e1s", "initials": "N", "orcid": "0000-0002-5184-9464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65797f47ca614ab88d8a11ec1ccf7207.json"}}, {"family": "Garcia-Marco", "given": "Jose Antonio", "initials": "JA", "orcid": "0000-0002-8993-5982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae24000421684dd4b672a42c0175db23.json"}}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jos\u00e9-\u00c1ngel", "initials": "J\u00c1", "orcid": "0000-0003-4550-757X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d071af0c0a14dc695bcda29033b49ce.json"}}, {"family": "Miras", "given": "Fatima", "initials": "F", "orcid": "0000-0001-5096-3145", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d86c6b42a4aa432195768fca2c6aa250.json"}}, {"family": "Coombs", "given": "Catherine C", "initials": "CC"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Seddon", "given": "Amanda N", "initials": "AN"}, {"family": "L\u00f3pez-Jim\u00e9nez", "given": "Javier", "initials": "J", "orcid": "0000-0002-2969-3002", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/49c7283585d74f94898db807e53654db.json"}}, {"family": "Wilson", "given": "Matthew R", "initials": "MR", "orcid": "0000-0001-5423-3270", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc62369e0fb6429f94baf3619752c379.json"}}, {"family": "El-Sharkawi", "given": "Dima", "initials": "D", "orcid": "0000-0002-2752-5814", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fedd8b1cbb8c4e7a8a4a1840484d1289.json"}}, {"family": "Wojenski", "given": "Daniel", "initials": "D"}, {"family": "Ma", "given": "Shuo", "initials": "S"}, {"family": "Munir", "given": "Talha", "initials": "T"}, {"family": "Valenciano", "given": "Susana", "initials": "S"}, {"family": "Seymour", "given": "Erlene", "initials": "E"}, {"family": "Barr", "given": "Paul M", "initials": "PM", "orcid": "0000-0002-9733-401X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0ab119d82bf451db7cf78e7869c7ceb.json"}}, {"family": "Pu", "given": "Jeffrey J", "initials": "JJ", "orcid": "0000-0001-7498-3159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/46d92e703b1e4634893c554254312a3f.json"}}, {"family": "Patten", "given": "Piers Em", "initials": "PE", "orcid": "0000-0003-3320-3034", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/245eaf4074b640499338cdf50ba61346.json"}}, {"family": "Perini", "given": "Guilherme Fleury", "initials": "GF"}, {"family": "Huntington", "given": "Scott F", "initials": "SF", "orcid": "0000-0001-7071-6475", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f9ee32a2ca0408697f8d8c1dfb185d8.json"}}, {"family": "Parry", "given": "Helen", "initials": "H", "orcid": "0000-0002-9707-8167", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5e7db11dc49496cac185fa8f9c99927.json"}}, {"family": "Sundaram", "given": "Suchitra", "initials": "S"}, {"family": "Skarbnik", "given": "Alan P", "initials": "AP"}, {"family": "Kamdar", "given": "Manali", "initials": "M"}, {"family": "Jacobs", "given": "Ryan W", "initials": "RW"}, {"family": "Walter", "given": "Harriet Sarah", "initials": "HS", "orcid": "0000-0003-2618-711X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76bd37449eda49b28de194fe74e9f289.json"}}, {"family": "Walewska", "given": "Renata", "initials": "R"}, {"family": "Broom", "given": "Angus", "initials": "A"}, {"family": "Lebowitz", "given": "Sonia", "initials": "S"}, {"family": "Isaac", "given": "Krista", "initials": "K", "orcid": "0000-0002-0234-139X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f2b9b13aac204070b5d7f7c3f69c123a.json"}}, {"family": "Portell", "given": "Craig A", "initials": "CA"}, {"family": "Ahn", "given": "Inhye E", "initials": "IE"}, {"family": "Ujjani", "given": "Chaitra", "initials": "C"}, {"family": "Shadman", "given": "Mazyar", "initials": "M", "orcid": "0000-0002-3365-6562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7856504963b74fbd85d7a62929233ed4.json"}}, {"family": "Sk\u00e5nland", "given": "Sigrid S", "initials": "SS"}, {"family": "Chong", "given": "Elise A", "initials": "EA"}, {"family": "Mato", "given": "Anthony R", "initials": "AR"}], "type": "journal article", "published": "2021-07-23", "journal": {"title": "Blood", "issn": "1528-0020", "issn-l": null}, "abstract": null, "doi": "10.1182/blood.2021011841", "pmid": "34297826", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "476453"}, {"db": "pmc", "key": "PMC8313815"}], "notes": [], "created": "2021-08-05T07:08:33.175Z", "modified": "2021-08-05T07:10:37.957Z"}, {"entity": "publication", "iuid": "3eb160a2384b417f8944066124b7e76b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3eb160a2384b417f8944066124b7e76b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3eb160a2384b417f8944066124b7e76b"}}, "title": "Anxiety, Compassion and Pride. How Emotions Elicited by the Government's Handling of Covid-19 Influences Health-Promoting Behavior.", "authors": [{"family": "Renstr\u00f6m", "given": "Emma A", "initials": "EA", "orcid": "0000-0001-6593-2464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c969b46ee25b4276916587537076440c.json"}}, {"family": "B\u00e4ck", "given": "Hanna", "initials": "H", "orcid": "0000-0002-0296-9419", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8afb5218cb145e99b138ef5b8d29f76.json"}}], "type": "journal article", "published": "2021-07-23", "journal": {"title": "Psychol Belg", "issn": "2054-670X", "volume": "61", "issue": "1", "pages": "224-237", "issn-l": null}, "abstract": "This article explores how emotions connected to the Government's handling of the Covid-19 outbreak in Sweden relates to behaviors to stop the spread of the virus, and which emotions functions as mediators in this relationship. The Swedish approach to handling the outbreak greatly differed from how many other Western European countries handled the situation and thus makes an important case to study. In a large representative survey (N = 2449), we found that satisfaction with how the Government handled the situation was related to more positive and less negative emotions. Anxiety, compassion and pride mediated the effect of satisfaction on compliance with the national recommendations such that anxiety and compassion increased compliance, while pride decreased it. Importantly though, satisfaction increased compassion and pride, but only compassion led to more compliant behaviors. In fact, satisfaction was indirectly related to less compliant behaviors via anxiety and pride. Shame mediated the effect on the tendency to wear face masks, a behavior that was explicitly not endorsed by the Swedish Public Health Agency. We speculate if the face mask, which was intensely debated, became a politicized symbol of dissatisfaction with the Swedish approach. In sum, it seems that individuals who were dissatisfied with how the government handled the Covid-19 outbreak were in fact engaging more in health-promotional behaviors to stop the spread of the virus.", "doi": "10.5334/pb.1053", "pmid": "34394949", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8300590"}], "notes": [], "created": "2021-08-17T06:43:53.775Z", "modified": "2021-08-17T06:43:53.850Z"}, {"entity": "publication", "iuid": "3023575e9ca747a4b7cb37e51b78464c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3023575e9ca747a4b7cb37e51b78464c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3023575e9ca747a4b7cb37e51b78464c"}}, "title": "Post-SARS-CoV-2-vaccination cerebral venous sinus thrombosis: an analysis of cases notified to the European Medicines Agency.", "authors": [{"family": "Krzywicka", "given": "Katarzyna", "initials": "K"}, {"family": "Heldner", "given": "Mirjam R", "initials": "MR", "orcid": "0000-0002-3594-2159", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8280f8c6ea3a486abae8acc6aa491985.json"}}, {"family": "S\u00e1nchez van Kammen", "given": "Mayte", "initials": "M"}, {"family": "van Haaps", "given": "Thijs", "initials": "T"}, {"family": "Hiltunen", "given": "Sini", "initials": "S"}, {"family": "Silvis", "given": "Suzanne M", "initials": "SM"}, {"family": "Levi", "given": "Marcel", "initials": "M", "orcid": "0000-0002-2212-5299", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d684119a7b2a42309d674f7094b81adc.json"}}, {"family": "Kremer Hovinga", "given": "Johanna A", "initials": "JA"}, {"family": "Jood", "given": "Katarina", "initials": "K"}, {"family": "Lindgren", "given": "Erik", "initials": "E"}, {"family": "Tatlisumak", "given": "Turgut", "initials": "T", "orcid": "0000-0002-2430-8988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03cddf3042b8470eaa083b6fa1e9e4bb.json"}}, {"family": "Putaala", "given": "Jukka", "initials": "J"}, {"family": "Aguiar de Sousa", "given": "Diana", "initials": "D", "orcid": "0000-0002-6702-7924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cc3515119a247859fe1fea025f703ef.json"}}, {"family": "Middeldorp", "given": "Saskia", "initials": "S", "orcid": "0000-0002-1006-6420", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03eef1eda4d0467084c5b8459e705cae.json"}}, {"family": "Arnold", "given": "Marcel", "initials": "M", "orcid": "0000-0002-4274-4644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10447e916b9b49f294e79a590139b9e3.json"}}, {"family": "Coutinho", "given": "Jonathan M", "initials": "JM", "orcid": "0000-0002-8284-982X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98cadafdcc044688bab25a3d7f9562b9.json"}}, {"family": "Ferro", "given": "Jos\u00e9 M", "initials": "JM", "orcid": "0000-0002-2343-9097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c8285bcf71c4ed1aa7b57a13c5cb70a.json"}}], "type": "journal article", "published": "2021-07-22", "journal": {"title": "Eur J Neurol", "issn": "1468-1331", "issn-l": null}, "abstract": "Cerebral venous sinus thrombosis (CVST) has been described after vaccination against SARS-CoV-2. The clinical characteristics of 213 post-vaccination CVST cases notified to the European Medicines Agency are reported.\n\nData on adverse drug reactions after SARS-CoV-2 vaccination notified until 8 April 2021 under the Medical Dictionary for Regulatory Activities Term 'Central nervous system vascular disorders' were obtained from the EudraVigilance database. Post-vaccination CVST was compared with 100 European patients with CVST from before the COVID-19 pandemic derived from the International CVST Consortium.\n\nIn all, 213 CVST cases were identified: 187 after AstraZeneca/Oxford (ChAdOx1 nCov-19) vaccination and 26 after a messenger RNA (mRNA) vaccination (25 with Pfizer/BioNTech, BNT162b2, and one with Moderna, mRNA-1273). Thrombocytopenia was reported in 107/187 CVST cases (57%, 95% confidence interval [CI] 50%-64%) in the ChAdOx1 nCov-19 group, in none in the mRNA vaccine group (0%, 95% CI 0%-13%) and in 7/100 (7%, 95% CI 3%-14%) in the pre-COVID-19 group. In the ChAdOx1 nCov-19 group, 39 (21%) reported COVID-19 polymerase chain reaction tests were performed within 30 days of CVST symptom onset, and all were negative. Of the 117 patients with a reported outcome in the ChAdOx1 nCov-19 group, 44 (38%, 95% CI 29%-47%) had died, compared to 2/10 (20%, 95% CI 6%-51%) in the mRNA vaccine group and 3/100 (3%, 95% CI 1%-8%) in the pre-COVID-19 group. Mortality amongst patients with thrombocytopenia in the ChAdOx1 nCov-19 group was 49% (95% CI 39%-60%).\n\nCerebral venous sinus thrombosis occurring after ChAdOx1 nCov-19 vaccination has a clinical profile distinct from CVST unrelated to vaccination. Only CVST after ChAdOx1 nCov-19 vaccination was associated with thrombocytopenia.", "doi": "10.1111/ene.15029", "pmid": "34293217", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-08-05T11:08:35.032Z", "modified": "2021-08-05T11:09:14.447Z"}, {"entity": "publication", "iuid": "c43b6b0e6a3b47f38b572fff9c87d349", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c43b6b0e6a3b47f38b572fff9c87d349.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c43b6b0e6a3b47f38b572fff9c87d349"}}, "title": "Physical activity and the risk of SARS-CoV-2 infection, severe COVID-19 illness and COVID-19 related mortality in South Korea: a nationwide cohort study.", "authors": [{"family": "Lee", "given": "Seung Won", "initials": "SW", "orcid": "0000-0001-5632-5208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b38b67e00dbf4d80a72a30152b99c0a3.json"}}, {"family": "Lee", "given": "Jinhee", "initials": "J"}, {"family": "Moon", "given": "Sung Yong", "initials": "SY"}, {"family": "Jin", "given": "Hyun Young", "initials": "HY"}, {"family": "Yang", "given": "Jee Myung", "initials": "JM"}, {"family": "Ogino", "given": "Shuji", "initials": "S"}, {"family": "Song", "given": "Mingyang", "initials": "M"}, {"family": "Hong", "given": "Sung Hwi", "initials": "SH"}, {"family": "Abou Ghayda", "given": "Ramy", "initials": "R"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Jacob", "given": "Louis", "initials": "L"}, {"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Smith", "given": "Lee", "initials": "L"}, {"family": "Giovannucci", "given": "Edward", "initials": "E"}, {"family": "Lee", "given": "I-Min", "initials": "IM", "orcid": "0000-0002-1083-6907", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d9a901889fd4ddabefdbab40fbaf1ae.json"}}, {"family": "Lee", "given": "Dong Hoon", "initials": "DH"}, {"family": "Lee", "given": "Keum Hwa", "initials": "KH"}, {"family": "Shin", "given": "Youn Ho", "initials": "YH"}, {"family": "Kim", "given": "So Young", "initials": "SY"}, {"family": "Kim", "given": "Min Seo", "initials": "MS", "orcid": "0000-0003-2115-7835", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3078a38bd45044b3ac5b32d0eb09fbda.json"}}, {"family": "Won", "given": "Hong-Hee", "initials": "HH"}, {"family": "Ekelund", "given": "Ulf", "initials": "U"}, {"family": "Shin", "given": "Jae Il", "initials": "JI"}, {"family": "Yon", "given": "Dong Keon", "initials": "DK", "orcid": "0000-0003-1628-9948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/747eb5856d2e444fbc1e5aaef8d3aa40.json"}}], "type": "journal article", "published": "2021-07-22", "journal": {"title": "Br J Sports Med", "issn": "1473-0480", "issn-l": null}, "abstract": "To determine the potential associations between physical activity and risk of SARS-CoV-2 infection, severe illness from COVID-19 and COVID-19 related death using a nationwide cohort from South Korea.\n\nData regarding 212 768 Korean adults (age \u226520 years), who tested for SARS-CoV-2, from 1 January 2020 to 30 May 2020, were obtained from the National Health Insurance Service of South Korea and further linked with the national general health examination from 1 January 2018 to 31 December 2019 to assess physical activity levels. SARS-CoV-2 positivity, severe COVID-19 illness and COVID-19 related death were the main outcomes. The observation period was between 1 January 2020 and 31 July 2020.\n\nOut of 76 395 participants who completed the general health examination and were tested for SARS-CoV-2, 2295 (3.0%) were positive for SARS-CoV-2, 446 (0.58%) had severe illness from COVID-19 and 45 (0.059%) died from COVID-19. Adults who engaged in both aerobic and muscle strengthening activities according to the 2018 physical activity guidelines had a lower risk of SARS-CoV-2 infection (2.6% vs 3.1%; adjusted relative risk (aRR), 0.85; 95% CI 0.72 to 0.96), severe COVID-19 illness (0.35% vs 0.66%; aRR 0.42; 95% CI 0.19 to 0.91) and COVID-19 related death (0.02% vs 0.08%; aRR 0.24; 95% CI 0.05 to 0.99) than those who engaged in insufficient aerobic and muscle strengthening activities. Furthermore, the recommended range of metabolic equivalent task (MET; 500-1000 MET min/week) was associated with the maximum beneficial effect size for reduced risk of SARS-CoV-2 infection (aRR 0.78; 95% CI 0.66 to 0.92), severe COVID-19 illness (aRR 0.62; 95% CI 0.43 to 0.90) and COVID-19 related death (aRR 0.17; 95% CI 0.07 to 0.98). Similar patterns of association were observed in different sensitivity analyses.\n\nAdults who engaged in the recommended levels of physical activity were associated with a decreased likelihood of SARS-CoV-2 infection, severe COVID-19 illness and COVID-19 related death. Our findings suggest that engaging in physical activity has substantial public health value and demonstrates potential benefits to combat COVID-19.", "doi": "10.1136/bjsports-2021-104203", "pmid": "34301715", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bjsports-2021-104203"}, {"db": "pmc", "key": "PMC8300550"}], "notes": [], "created": "2021-08-05T07:06:44.215Z", "modified": "2021-08-05T07:06:45.565Z"}, {"entity": "publication", "iuid": "1a006b8339e64c42b03e1e4d6206b370", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1a006b8339e64c42b03e1e4d6206b370.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1a006b8339e64c42b03e1e4d6206b370"}}, "title": "Marine Sulfated Polysaccharides as Promising Antiviral Agents: A Comprehensive Report and Modeling Study Focusing on SARS CoV-2.", "authors": [{"family": "Salih", "given": "Abdalla E M", "initials": "AEM"}, {"family": "Thissera", "given": "Bathini", "initials": "B", "orcid": "0000-0002-0998-4187", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b46765518df488e9f7433b162103dde.json"}}, {"family": "Yaseen", "given": "Mohammed", "initials": "M", "orcid": "0000-0002-2460-1893", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b57b297419fe47188812beeaffc62cf0.json"}}, {"family": "Hassane", "given": "Ahmed S I", "initials": "ASI"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}, {"family": "Sayed", "given": "Ahmed M", "initials": "AM", "orcid": "0000-0002-1442-183X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/013ee0ba73bb4d7f87fd285c65e49725.json"}}, {"family": "Rateb", "given": "Mostafa E", "initials": "ME", "orcid": "0000-0003-4043-2687", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59c7eb5f74ca45f695bffb7960cbedcc.json"}}], "type": "journal article", "published": "2021-07-22", "journal": {"title": "Mar Drugs", "issn": "1660-3397", "volume": "19", "issue": "8", "pages": "406", "issn-l": null}, "abstract": "SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) is a novel coronavirus strain that emerged at the end of 2019, causing millions of deaths so far. Despite enormous efforts being made through various drug discovery campaigns, there is still a desperate need for treatments with high efficacy and selectivity. Recently, marine sulfated polysaccharides (MSPs) have earned significant attention and are widely examined against many viral infections. This article attempted to produce a comprehensive report about MSPs from different marine sources alongside their antiviral effects against various viral species covering the last 25 years of research articles. Additionally, these reported MSPs were subjected to molecular docking and dynamic simulation experiments to ascertain potential interactions with both the receptor-binding domain (RBD) of SARS CoV-2's spike protein (S-protein) and human angiotensin-converting enzyme-2 (ACE2). The possible binding sites on both S-protein's RBD and ACE2 were determined based on how they bind to heparin, which has been reported to exhibit significant antiviral activity against SARS CoV-2 through binding to RBD, preventing the virus from affecting ACE2. Moreover, our modeling results illustrate that heparin can also bind to and block ACE2, acting as a competitor and protective agent against SARS CoV-2 infection. Nine of the investigated MSPs candidates exhibited promising results, taking into consideration the newly emerged SARS CoV-2 variants, of which five were not previously reported to exert antiviral activity against SARS CoV-2, including sulfated galactofucan (1), sulfated polymannuroguluronate (SPMG) (2), sulfated mannan (3), sulfated heterorhamnan (8), and chondroitin sulfate E (CS-E) (9). These results shed light on the importance of sulfated polysaccharides as potential SARS-CoV-2 inhibitors.", "doi": "10.3390/md19080406", "pmid": "34436245", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "md19080406"}, {"db": "pmc", "key": "PMC8401819"}], "notes": [], "created": "2021-08-27T09:35:33.179Z", "modified": "2021-09-01T07:17:08.967Z"}, {"entity": "publication", "iuid": "5f137f6991f648d0876bfdbe5a44aab0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f137f6991f648d0876bfdbe5a44aab0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f137f6991f648d0876bfdbe5a44aab0"}}, "title": "Ultrametric diffusion equation on energy landscape to model disease spread in hierarchic socially clustered population.", "authors": [{"family": "Khrennikov", "given": "Andrei", "initials": "A"}], "type": "journal article", "published": "2021-07-21", "journal": {"title": "Physica A", "issn": "0378-4371", "pages": "126284", "issn-l": null}, "abstract": "We present a new mathematical model of disease spread reflecting some specialties of the covid-19 epidemic by elevating the role of hierarchic social clustering of population. The model can be used to explain slower approaching herd immunity, e.g., in Sweden, than it was predicted by a variety of other mathematical models and was expected by epidemiologists; see graphs Fig. 1,2. The hierarchic structure of social clusters is mathematically modeled with ultrametric spaces having treelike geometry. To simplify mathematics, we consider trees with the constant number of branches leaving each vertex. Such trees are endowed with an algebraic structure, these are p > 1 -adic number fields. We apply theory of the p -adic diffusion equation to describe a virus spread in hierarchically clustered population. This equation has applications to statistical physics and microbiology for modeling pdynamics on energy landscapes. To move from one social cluster (valley) to another, a virus (its carrier) should cross a social barrier between them. The magnitude of a barrier depends on the number of social hierarchy's levels composing this barrier. We consider linearly increasing barriers. A virus spreads rather easily inside a social cluster (say working collective), but jumps to other clusters are constrained by social barriers. This behavior matches with the covid-19 epidemic, with its cluster spreading structure. Our model differs crucially from the standard mathematical models of spread of disease, such as the SIR-model; in particular, by notion of the probability to be infected (at time in a social cluster t ). We present socio-medical specialties of the covid-19 epidemic supporting our model.C", "doi": "10.1016/j.physa.2021.126284", "pmid": "34312573", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0378-4371(21)00557-4"}, {"db": "pmc", "key": "PMC8294751"}], "notes": [], "created": "2021-08-05T06:50:47.154Z", "modified": "2021-08-05T06:50:47.181Z"}, {"entity": "publication", "iuid": "ee384aaba0c94162879c0d22e3f0f263", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee384aaba0c94162879c0d22e3f0f263.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee384aaba0c94162879c0d22e3f0f263"}}, "title": "Impact of the COVID-19 pandemic on the management of chronic noninfectious respiratory diseases.", "authors": [{"family": "Tiotiu", "given": "Angelica", "initials": "A", "orcid": "0000-0002-8038-9559", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7ee2c77aeb734a9dbb4746210468f2d5.json"}}, {"family": "Chong Neto", "given": "Herberto", "initials": "H"}, {"family": "Bikov", "given": "Andras", "initials": "A"}, {"family": "Kowal", "given": "Krzysztof", "initials": "K"}, {"family": "Steiropoulos", "given": "Paschalis", "initials": "P"}, {"family": "Labor", "given": "Marina", "initials": "M", "orcid": "0000-0001-5216-8129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9a750b29a224b7bb07d535004dfdf15.json"}}, {"family": "Cherrez-Ojeda", "given": "Ivan", "initials": "I", "orcid": "0000-0002-1610-239X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ee022e7bd4d4b80baa3c24aa98c0b92.json"}}, {"family": "Badellino", "given": "Hector", "initials": "H"}, {"family": "Emelyanov", "given": "Alexander", "initials": "A"}, {"family": "Garcia", "given": "Rocio", "initials": "R"}, {"family": "Guidos", "given": "Guillermo", "initials": "G", "orcid": "0000-0003-1675-3894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9446a00028a248e49be76f868ee7c701.json"}}], "type": "journal article", "published": "2021-07-21", "journal": {"title": "Expert Rev Respir Med", "issn": "1747-6356", "pages": "1-14", "issn-l": null}, "abstract": "Introduction: The COVID-19 pandemic has challenged health care across the world, not just by the severity of the disease and the high mortality rate but also by the consequences on the management of the patients with chronic diseases.Areas covered: This review summarizes the most up-to-date published data regarding the impact of COVID-19 on the management and outcomes of patients with chronic noninfectious respiratory illnesses including obstructive sleep apnea, asthma, chronic obstructive pulmonary disease, bronchiectasis, interstitial and pulmonary vascular diseases, and lung cancer.Expert opinion: Most of chronic respiratory diseases (except asthma and cystic fibrosis) are associated with more severe COVID-19 and poor outcomes but the mechanisms involved are not yet identified. The therapeutic management of the patients with chronic respiratory diseases and COVID-19 is similar to the other patients but the post-recovery course could be worse in this population and followed by the development of pulmonary fibrosis, bronchiectasis, and pulmonary hypertension. The pandemic highly impacted our usual medical activities by limiting the access to several diagnosis procedures, the necessity to develop new methods for the monitoring of the disease and adapt the therapeutic strategies. The long-term consequences of all these changes are still unknown.", "doi": "10.1080/17476348.2021.1951707", "pmid": "34253132", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:35:18.427Z", "modified": "2021-08-06T07:35:30.520Z"}, {"entity": "publication", "iuid": "dde1dda8dae541878726006521406dfd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dde1dda8dae541878726006521406dfd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dde1dda8dae541878726006521406dfd"}}, "title": "Dapagliflozin in patients with cardiometabolic risk factors hospitalised with COVID-19 (DARE-19): a randomised, double-blind, placebo-controlled, phase 3 trial.", "authors": [{"family": "Kosiborod", "given": "Mikhail N", "initials": "MN"}, {"family": "Esterline", "given": "Russell", "initials": "R"}, {"family": "Furtado", "given": "Remo H M", "initials": "RHM"}, {"family": "Oscarsson", "given": "Jan", "initials": "J"}, {"family": "Gasparyan", "given": "Samvel B", "initials": "SB"}, {"family": "Koch", "given": "Gary G", "initials": "GG"}, {"family": "Martinez", "given": "Felipe", "initials": "F"}, {"family": "Mukhtar", "given": "Omar", "initials": "O"}, {"family": "Verma", "given": "Subodh", "initials": "S"}, {"family": "Chopra", "given": "Vijay", "initials": "V"}, {"family": "Buenconsejo", "given": "Joan", "initials": "J"}, {"family": "Langkilde", "given": "Anna Maria", "initials": "AM"}, {"family": "Ambery", "given": "Philip", "initials": "P"}, {"family": "Tang", "given": "Fengming", "initials": "F"}, {"family": "Gosch", "given": "Kensey", "initials": "K"}, {"family": "Windsor", "given": "Sheryl L", "initials": "SL"}, {"family": "Akin", "given": "Emily E", "initials": "EE"}, {"family": "Soares", "given": "Ronaldo V P", "initials": "RVP"}, {"family": "Moia", "given": "Diogo D F", "initials": "DDF"}, {"family": "Aboudara", "given": "Matthew", "initials": "M"}, {"family": "Hoffmann Filho", "given": "Conrado Roberto", "initials": "CR"}, {"family": "Feitosa", "given": "Audes D M", "initials": "ADM"}, {"family": "Fonseca", "given": "Alberto", "initials": "A"}, {"family": "Garla", "given": "Vishnu", "initials": "V"}, {"family": "Gordon", "given": "Robert A", "initials": "RA"}, {"family": "Javaheri", "given": "Ali", "initials": "A"}, {"family": "Jaeger", "given": "Cristiano P", "initials": "CP"}, {"family": "Leaes", "given": "Paulo E", "initials": "PE"}, {"family": "Nassif", "given": "Michael", "initials": "M"}, {"family": "Pursley", "given": "Michael", "initials": "M"}, {"family": "Silveira", "given": "Fabio Serra", "initials": "FS"}, {"family": "Barroso", "given": "Weimar Kunz Sebba", "initials": "WKS"}, {"family": "Lazcano Soto", "given": "Jos\u00e9 Roberto", "initials": "JR"}, {"family": "Nigro Maia", "given": "Lilia", "initials": "L"}, {"family": "Berwanger", "given": "Otavio", "initials": "O"}], "type": "journal article", "published": "2021-07-21", "journal": {"title": "Lancet Diabetes Endocrinol", "issn": "2213-8595", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "COVID-19 can lead to multiorgan failure. Dapagliflozin, a SGLT2 inhibitor, has significant protective benefits for the heart and kidney. We aimed to see whether this agent might provide organ protection in patients with COVID-19 by affecting processes dysregulated during acute illness.\r\n\r\nDARE-19 was a randomised, double-blind, placebo-controlled trial of patients hospitalised with COVID-19 and with at least one cardiometabolic risk factor (ie, hypertension, type 2 diabetes, atherosclerotic cardiovascular disease, heart failure, and chronic kidney disease). Patients critically ill at screening were excluded. Patients were randomly assigned 1:1 to dapagliflozin (10 mg daily orally) or matched placebo for 30 days. Dual primary outcomes were assessed in the intention-to-treat population: the outcome of prevention (time to new or worsened organ dysfunction or death), and the hierarchial composite outcome of recovery (change in clinical status by day 30). Safety outcomes, in patients who received at least one study medication dose, included serious adverse events, adverse events leading to discontinuation, and adverse events of interest. This study is registered with ClinicalTrials.gov, NCT04350593.\r\n\r\nBetween April 22, 2020 and Jan 1, 2021, 1250 patients were randomly assigned with 625 in each group. The primary composite outcome of prevention showed organ dysfunction or death occurred in 70 patients (11\u00b72%) in the dapagliflozin group, and 86 (13\u00b78%) in the placebo group (hazard ratio [HR] 0\u00b780, 95% CI 0\u00b758-1\u00b710; p=0\u00b717). For the primary outcome of recovery, 547 patients (87\u00b75%) in the dapagliflozin group and 532 (85\u00b71%) in the placebo group showed clinical status improvement, although this was not statistically significant (win ratio 1\u00b709, 95% CI 0\u00b797-1\u00b722; p=0\u00b714). There were 41 deaths (6\u00b76%) in the dapagliflozin group, and 54 (8\u00b76%) in the placebo group (HR 0\u00b777, 95% CI 0\u00b752-1\u00b716). Serious adverse events were reported in 65 (10\u00b76%) of 613 patients treated with dapagliflozin and in 82 (13\u00b73%) of 616 patients given the placebo.\r\n\r\nIn patients with cardiometabolic risk factors who were hospitalised with COVID-19, treatment with dapagliflozin did not result in a statistically significant risk reduction in organ dysfunction or death, or improvement in clinical recovery, but was well tolerated.\r\n\r\nAstraZeneca.", "doi": "10.1016/S2213-8587(21)00180-7", "pmid": "34302745", "labels": {"Category: Biochemistry": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2213-8587(21)00180-7"}, {"db": "pmc", "key": "PMC8294807"}, {"db": "ClinicalTrials.gov", "key": "NCT04350593"}], "notes": [], "created": "2021-08-05T07:04:41.191Z", "modified": "2021-08-05T07:06:23.441Z"}, {"entity": "publication", "iuid": "f679a141107f4d0989dcf6a28593d307", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f679a141107f4d0989dcf6a28593d307.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f679a141107f4d0989dcf6a28593d307"}}, "title": "The role of psychological flexibility, perceived injustice and body image in Vulvodynia: A longitudinal study.", "authors": [{"family": "Chisari", "given": "Claudia", "initials": "C", "orcid": "0000-0002-1118-7443", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7db18ed16a6b4626a61233e39134480f.json"}}, {"family": "Budhraja", "given": "Mahira", "initials": "M", "orcid": "0000-0001-6211-1580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8157535613a1480ea74dba80561d0247.json"}}, {"family": "Monajemi", "given": "Mani B", "initials": "MB", "orcid": "0000-0002-9052-817X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4bc7992e02a641258745fd8f24a7d922.json"}}, {"family": "Lewis", "given": "Fiona", "initials": "F", "orcid": "0000-0003-4267-1518", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/229a764990744509b093aafb03e20143.json"}}, {"family": "Moss-Morris", "given": "Rona", "initials": "R", "orcid": "0000-0002-2927-3446", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9d47c00d0c4244b2858091fbf7bd0160.json"}}, {"family": "Scott", "given": "Whitney", "initials": "W", "orcid": "0000-0002-2529-9083", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4e786db5451e41b99b48253784db8af8.json"}}, {"family": "McCracken", "given": "Lance M", "initials": "LM", "orcid": "0000-0002-9734-0153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e7520672ca04462b00b191b756a1b7a.json"}}], "type": "journal article", "published": "2021-07-20", "journal": {"title": "Eur J Pain", "issn": "1532-2149", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Women with Vulvodynia experience pain, related impacts on sex and daily functioning, and depression. While psychosocial factors are associated with outcomes in Vulvodynia, longitudinal data are limited, especially in mixed/spontaneous Vulvodynia. Broad psychological models such as psychological flexibility (PF) and content-specific factors, such as body-exposure anxiety (BEA) and avoidance during sexual activities and perceived injustice, have not been adequately investigated in Vulvodynia. The aim of this study was to explore whether these factors assessed at baseline predict pain severity, pain interference, sexual functioning and satisfaction and depression 3 months later.\r\n\r\nA longitudinal study of 349 women with Vulvodynia was conducted. Participants completed online self-report measures of pain-related and sexual outcomes, depression, BEA, perceived injustice and facets of PF (present moment awareness, pain acceptance, committed action) at baseline and after 3 months, overlapping with the Coronavirus disease 2019 (COVID-19) pandemic.\r\n\r\nSeventy percent of women responded at both assessments (n = 244). There were significant decreases in pain severity, pain interference, present moment awareness, committed action and a significant increase in depression at 3 months. All the baseline psychosocial factors significantly correlated with at least one outcome at 3 months. When adjusting for baseline outcome and demographics, committed action significantly positively predicted depression at 3 months and pain acceptance significantly positively predicted pain interference at 3 months.\r\n\r\nAmong women with Vulvodynia, pain acceptance and committed action are prospectively associated with pain interference and depression. The reliability and generalizability of these results needs to be established given the overlap with the COVID-19 pandemic. Future studies should investigate whether targeting these factors enhances outcomes in Vulvodynia.\r\n\r\nThis longitudinal study explored the role of PF, perceived injustice and body image during sexual activities in predicting pain severity, pain interference, sexual functioning, sexual satisfaction and depression in women with Vulvodynia. The study findings reveal that two facets of PF (committed action and pain acceptance) predicted pain interference and depression over time. It may be important to incorporate these processes in treatments developed for Vulvodynia.", "doi": "10.1002/ejp.1841", "pmid": "34288269", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-05T11:10:05.526Z", "modified": "2021-11-18T11:42:07.844Z"}, {"entity": "publication", "iuid": "3c1f7865c030414ba948b78279881d3b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3c1f7865c030414ba948b78279881d3b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3c1f7865c030414ba948b78279881d3b"}}, "title": "Self-reported neurocognitive symptoms during COVID-19 lockdown and its associated factors in a sample of psychiatric patients. Results from the BRIS-MHC study.", "authors": [{"family": "Montejo", "given": "Laura", "initials": "L"}, {"family": "Sol\u00e9", "given": "Brisa", "initials": "B"}, {"family": "Verdolini", "given": "Norma", "initials": "N"}, {"family": "Mart\u00ednez-Ar\u00e1n", "given": "Anabel", "initials": "A"}, {"family": "Bonn\u00edn", "given": "Caterina Del Mar", "initials": "CDM"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Mart\u00edn-Villalba", "given": "In\u00e9s", "initials": "I"}, {"family": "Williams", "given": "Evelin", "initials": "E"}, {"family": "Garc\u00eda-Rizo", "given": "Clemente", "initials": "C"}, {"family": "Mezquida", "given": "Gisela", "initials": "G"}, {"family": "Bernardo", "given": "Miguel", "initials": "M"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Torrent", "given": "Carla", "initials": "C"}, {"family": "Amoretti", "given": "Silvia", "initials": "S"}, {"family": "BRIS-MHC research group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-07-20", "journal": {"title": "Eur Neuropsychopharmacol", "issn": "1873-7862", "volume": "53", "pages": "7-18", "issn-l": null}, "abstract": "Lockdown caused by COVID-19 pandemic has a negative impact on mental health. The aim was to assess self-reported neurocognitive symptoms during the lockdown and identify associated vulnerable and protective factors in a sample of psychiatric patients in a Spanish population. These results are part of the Barcelona ResIlience Survey for Mental Health COVID-19 (BRIS-MHC) project. Neurocognitive symptoms were assessed through an online survey considering the five items that represented self-reported neurocognitive complaints. We split the sample into two groups based on the severity of the self-reported neurocognitive complaints: intact cognitive function/mild cognitive impairment (CI-) and moderate/severe cognitive impairment (CI+). Univariate analyses were used to compare both groups in terms of sociodemographic and clinical variables. Multiple logistic regression models were carried out to identify clinical variables and coping strategies associated with neurocognitive symptoms. 198 patients with different psychiatric diagnoses were included in this study. One hundred seventeen patients were classified in the CI- group and 81 in the CI+ group. Depressive symptoms and negative psychotic-like symptoms were vulnerable factors for neurocognitive impairment. Coping strategies of performing physical activity, carrying out relaxing activities and maintaining a routine were protective factors against cognitive impairment. Lockdown situation negatively impact on neurocognitive function. Psychopathological symptoms and coping strategies were associated with neurocognitive symptoms during lockdown in subjects with psychiatric illness. The early treatment of psychopathological symptoms in psychiatric patients and promoting coping strategies during lockdown should be considered an intervention strategy against cognitive impairment.", "doi": "10.1016/j.euroneuro.2021.07.006", "pmid": "34348213", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0924-977X(21)00275-3"}], "notes": [], "created": "2021-08-06T09:43:53.370Z", "modified": "2021-08-06T09:43:53.393Z"}, {"entity": "publication", "iuid": "a7b20101f22d4155888dae5620248fa0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7b20101f22d4155888dae5620248fa0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7b20101f22d4155888dae5620248fa0"}}, "title": "Excess all-cause mortality and COVID-19-related mortality: a temporal analysis in 22 countries, from January until August 2020.", "authors": [{"family": "Achilleos", "given": "Souzana", "initials": "S", "orcid": "0000-0002-1688-9225", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce5b51f054484805abea56ebad2bffc6.json"}}, {"family": "Quattrocchi", "given": "Annalisa", "initials": "A", "orcid": "0000-0002-5764-6721", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9a78ec6310743ec9b60a592a0ac61bd.json"}}, {"family": "Gabel", "given": "John", "initials": "J"}, {"family": "Heraclides", "given": "Alexandros", "initials": "A", "orcid": "0000-0002-1304-3275", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c763a75d0dc4841adfc2f0ea63abb3b.json"}}, {"family": "Kolokotroni", "given": "Ourania", "initials": "O", "orcid": "0000-0002-7653-002X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f695065afcc4c2a9dc89ac04506279b.json"}}, {"family": "Constantinou", "given": "Constantina", "initials": "C"}, {"family": "Pagola Ugarte", "given": "Maider", "initials": "M"}, {"family": "Nicolaou", "given": "Nicoletta", "initials": "N"}, {"family": "Rodriguez-Llanes", "given": "Jose Manuel", "initials": "JM"}, {"family": "Bennett", "given": "Catherine Marie", "initials": "CM"}, {"family": "Bogatyreva", "given": "Ekaterina", "initials": "E"}, {"family": "Schernhammer", "given": "Eva", "initials": "E", "orcid": "0000-0002-4337-9415", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5ada7385c4ac4d168d76e00d8383133b.json"}}, {"family": "Zimmermann", "given": "Claudia", "initials": "C"}, {"family": "Costa", "given": "Antonio Jose Leal", "initials": "AJL"}, {"family": "Lobato", "given": "Jackeline Christiane Pinto", "initials": "JCP"}, {"family": "Fernandes", "given": "Ngibo Mubeta", "initials": "NM"}, {"family": "Semedo-Aguiar", "given": "Ana Paula", "initials": "AP"}, {"family": "Jaramillo Ramirez", "given": "Gloria Isabel", "initials": "GI"}, {"family": "Martin Garzon", "given": "Oscar Dario", "initials": "OD"}, {"family": "Mortensen", "given": "Laust Hvas", "initials": "LH"}, {"family": "Critchley", "given": "Julia A", "initials": "JA"}, {"family": "Goldsmith", "given": "Lucy P", "initials": "LP"}, {"family": "Denissov", "given": "Gleb", "initials": "G"}, {"family": "R\u00fc\u00fctel", "given": "Kristi", "initials": "K"}, {"family": "Le Meur", "given": "Nolwenn", "initials": "N", "orcid": "0000-0001-8451-4014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7ccd56127144ac4b7044dfaf98ca8e6.json"}}, {"family": "Kandelaki", "given": "Levan", "initials": "L"}, {"family": "Tsiklauri", "given": "Shorena", "initials": "S"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}, {"family": "Oza", "given": "Ajay", "initials": "A"}, {"family": "Kaufman", "given": "Zalman", "initials": "Z"}, {"family": "Zucker", "given": "Inbar", "initials": "I"}, {"family": "Ambrosio", "given": "Giuseppe", "initials": "G"}, {"family": "Stracci", "given": "Fabrizio", "initials": "F"}, {"family": "Hagen", "given": "Terje P", "initials": "TP"}, {"family": "Erzen", "given": "Ivan", "initials": "I"}, {"family": "Klepac", "given": "Petra", "initials": "P"}, {"family": "Arcos Gonz\u00e1lez", "given": "Pedro", "initials": "P"}, {"family": "Fern\u00e1ndez Camporro", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "Burstr\u00f6m", "given": "Bo", "initials": "B"}, {"family": "Pidmurniak", "given": "Nataliia", "initials": "N"}, {"family": "Verstiuk", "given": "Olesia", "initials": "O"}, {"family": "Huang", "given": "Qian", "initials": "Q"}, {"family": "Mehta", "given": "Neil Kishor", "initials": "NK"}, {"family": "Polemitis", "given": "Antonis", "initials": "A"}, {"family": "Charalambous", "given": "Andreas", "initials": "A"}, {"family": "Demetriou", "given": "Christiana A", "initials": "CA", "orcid": "0000-0003-4002-2880", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00673897042047668d72abac855f4cc8.json"}}], "type": "journal article", "published": "2021-07-20", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "issn-l": "0300-5771"}, "abstract": "This study aimed to investigate overall and sex-specific excess all-cause mortality since the inception of the COVID-19 pandemic until August 2020 among 22 countries.\n\nCountries reported weekly or monthly all-cause mortality from January 2015 until the end of June or August 2020. Weekly or monthly COVID-19 deaths were reported for 2020. Excess mortality for 2020 was calculated by comparing weekly or monthly 2020 mortality (observed deaths) against a baseline mortality obtained from 2015-2019 data for the same week or month using two methods: (i) difference in observed mortality rates between 2020 and the 2015-2019 average and (ii) difference between observed and expected 2020 deaths.\n\nBrazil, France, Italy, Spain, Sweden, the UK (England, Wales, Northern Ireland and Scotland) and the USA demonstrated excess all-cause mortality, whereas Australia, Denmark and Georgia experienced a decrease in all-cause mortality. Israel, Ukraine and Ireland demonstrated sex-specific changes in all-cause mortality.\n\nAll-cause mortality up to August 2020 was higher than in previous years in some, but not all, participating countries. Geographical location and seasonality of each country, as well as the prompt application of high-stringency control measures, may explain the observed variability in mortality changes.", "doi": "10.1093/ije/dyab123", "pmid": "34282450", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6324094"}], "notes": [], "created": "2021-08-05T11:10:50.663Z", "modified": "2021-08-05T11:10:50.818Z"}, {"entity": "publication", "iuid": "5180e25d70e04467a74f2ece3c74865d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5180e25d70e04467a74f2ece3c74865d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5180e25d70e04467a74f2ece3c74865d"}}, "title": "Collective insights of public-private partnership impacts and sustainability: A qualitative analysis.", "authors": [{"family": "Strasser", "given": "Sheryl", "initials": "S", "orcid": "0000-0002-6813-7180", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a8f19d212059447f80d8a0c0c6c2c341.json"}}, {"family": "Stauber", "given": "Christine", "initials": "C"}, {"family": "Shrivastava", "given": "Ritu", "initials": "R"}, {"family": "Riley", "given": "Patricia", "initials": "P", "orcid": "0000-0002-2901-5834", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5853c1026896400997d09c70f192819b.json"}}, {"family": "O'Quin", "given": "Karen", "initials": "K"}], "type": "journal article", "published": "2021-07-20", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "7", "pages": "e0254495"}, "abstract": "The global Coronavirus or COVID-19 pandemic exposed the weakness of healthcare systems including laboratory systems and is a call to action for unprecedented collaboration and partnerships to deal with the global crisis. The United States (U.S.) President's Emergency Plan for AIDS Relief (PEPFAR) establishes the global HIV/AIDS treatment agenda in alignment with the UNAIDS 90-90-90 treatment targets to achieve epidemic control related to enhanced testing, treatment, and viral suppression. A strategic PEPFAR priority area recognizes that large-scale collective efforts and sharing of resources bear greater potential impact for lasting change than any single organization or entity can achieve alone. An important vehicle utilized within the global public health context is the public-private partnership (PPP) model whereby multiple international organizations forge unified project charters to collectively reach mutually agreed goals. While touted as an ideal mechanism to synthesize resources and maximize gain in numerous applications, little is known from a seasoned stakeholder perspective regarding PPP implementation and sustainability issues. The purpose of this research is to holistically examine perceptions of PPP model sustainability related to inputs and impacts among a collective network of stakeholders experienced with PEPFAR workforce development, laboratory-system strengthening project implementation. Interviews were conducted with frontline stakeholders from public and private sector organizations based in the US and select PEPFAR-supported priority countries. Analysis revealed three dominant themes: PPP impacts, keys of successful collaboration, and logistical challenges and opportunities to enhance sustainability of PPP outcomes in the future.", "doi": "10.1371/journal.pone.0254495", "pmid": "34283847", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-32179"}, {"db": "pmc", "key": "PMC8291689"}], "notes": [], "created": "2021-08-05T11:10:28.875Z", "modified": "2021-11-18T09:37:43.715Z"}, {"entity": "publication", "iuid": "4dbd1bbcf14f4041ade0b1493564840e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4dbd1bbcf14f4041ade0b1493564840e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4dbd1bbcf14f4041ade0b1493564840e"}}, "title": "Assessment of Ventilation and Perfusion in Patients with COVID-19 Discloses Unique Information of Pulmonary Function to a Clinician: Case Reports of V/P SPECT.", "authors": [{"family": "Bajc", "given": "Marika", "initials": "M"}, {"family": "Hedeer", "given": "Fredrik", "initials": "F"}, {"family": "Lindqvist", "given": "Ari", "initials": "A", "orcid": "0000-0002-0062-0117", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a1ce81ade04c476facbbdd9ddea80939.json"}}, {"family": "Tr\u00e4g\u00e5rdh", "given": "Elin", "initials": "E"}], "type": "case reports", "published": "2021-07-20", "journal": {"title": "Clin Med Insights Circ Respir Pulm Med", "issn": "1179-5484", "issn-l": null, "volume": "15", "issue": null, "pages": "11795484211030159"}, "abstract": "V/P SPECT from 4 consecutive patients with COVID-19 suggests that ventilation and perfusion images may be applied to diagnose or exclude pulmonary embolism, verify nonsegmental diversion of perfusion from the ventilated areas (dead space ventilation) that may represent inflammation of the pulmonary vasculature, detect the reversed mismatch of poor ventilation and better preserved perfusion (shunt perfusion) in bilateral pulmonary inflammation and indicate redistribution of lung perfusion (antigravitational hyperperfusion) due to cardiac congestion. V/P mismatch and reversed mismatch may be extensive enough to diminish dramatically preserved matching ventilation/perfusion and to induce severe hypoxemia in COVID-19.", "doi": "10.1177/11795484211030159", "pmid": "34349582", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8295940"}, {"db": "pii", "key": "10.1177_11795484211030159"}], "notes": [], "created": "2021-08-06T09:24:03.461Z", "modified": "2023-06-19T15:03:14.197Z"}, {"entity": "publication", "iuid": "648b7d9ffa0c4927b2654baea33b717e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/648b7d9ffa0c4927b2654baea33b717e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/648b7d9ffa0c4927b2654baea33b717e"}}, "title": "Using a household-structured branching process to analyse contact tracing in the SARS-CoV-2 pandemic.", "authors": [{"family": "Fyles", "given": "Martyn", "initials": "M"}, {"family": "Fearon", "given": "Elizabeth", "initials": "E"}, {"family": "Overton", "given": "Christopher", "initials": "C"}, {"family": "University of Manchester COVID-19 Modelling Group", "given": "", "initials": ""}, {"family": "Wingfield", "given": "Tom", "initials": "T"}, {"family": "Medley", "given": "Graham F", "initials": "GF"}, {"family": "Hall", "given": "Ian", "initials": "I"}, {"family": "Pellis", "given": "Lorenzo", "initials": "L"}, {"family": "House", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2021-07-19", "journal": {"title": "Philos Trans R Soc Lond B Biol Sci", "issn": "1471-2970", "issn-l": null, "volume": "376", "issue": "1829", "pages": "20200267"}, "abstract": "We explore strategies of contact tracing, case isolation and quarantine of exposed contacts to control the SARS-CoV-2 epidemic using a branching process model with household structure. This structure reflects higher transmission risks among household members than among non-household members. We explore strategic implementation choices that make use of household structure, and investigate strategies including two-step tracing, backwards tracing, smartphone tracing and tracing upon symptom report rather than test results. The primary model outcome is the effect of contact tracing, in combination with different levels of physical distancing, on the growth rate of the epidemic. Furthermore, we investigate epidemic extinction times to indicate the time period over which interventions must be sustained. We consider effects of non-uptake of isolation/quarantine, non-adherence, and declining recall of contacts over time. Our results find that, compared to self-isolation of cases without contact tracing, a contact tracing strategy designed to take advantage of household structure allows for some relaxation of physical distancing measures but cannot completely control the epidemic absent of other measures. Even assuming no imported cases and sustainment of moderate physical distancing, testing and tracing efforts, the time to bring the epidemic to extinction could be in the order of months to years. This article is part of the theme issue 'Modelling that shaped the early COVID-19 pandemic response in the UK'.", "doi": "10.1098/rstb.2020.0267", "pmid": "34053253", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "URL", "key": "https://github.com/martyn1fyles/HouseholdContactTracing", "description": "Data and code"}], "notes": [], "created": "2021-06-04T11:32:17.300Z", "modified": "2021-11-18T09:36:35.538Z"}, {"entity": "publication", "iuid": "290c919c0c1b4505aaa40d3d71d3c62f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/290c919c0c1b4505aaa40d3d71d3c62f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/290c919c0c1b4505aaa40d3d71d3c62f"}}, "title": "The collaborative outcomes study on health and functioning during infection times in adults (COH-FIT-Adults): Design and methods of an international online survey targeting physical and mental health effects of the COVID-19 pandemic.", "authors": [{"family": "Solmi", "given": "Marco", "initials": "M"}, {"family": "Estrad\u00e9", "given": "Andr\u00e9s", "initials": "A"}, {"family": "Thompson", "given": "Trevor", "initials": "T"}, {"family": "Agorastos", "given": "Agorastos", "initials": "A"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Cortese", "given": "Samuele", "initials": "S"}, {"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Leisch", "given": "Friedrich", "initials": "F"}, {"family": "Vancampfort", "given": "Davy", "initials": "D"}, {"family": "Thygesen", "given": "Lau Caspar", "initials": "LC"}, {"family": "Aschauer", "given": "Harald", "initials": "H"}, {"family": "Schloegelhofer", "given": "Monika", "initials": "M"}, {"family": "Akimova", "given": "Elena", "initials": "E"}, {"family": "Schneeberger", "given": "Andres", "initials": "A"}, {"family": "Huber", "given": "Christian G", "initials": "CG"}, {"family": "Hasler", "given": "Gregor", "initials": "G"}, {"family": "Conus", "given": "Philippe", "initials": "P"}, {"family": "Cu\u00e9nod", "given": "Kim Q Do", "initials": "KQD"}, {"family": "von K\u00e4nel", "given": "Roland", "initials": "R"}, {"family": "Arrondo", "given": "Gonzalo", "initials": "G"}, {"family": "Fusar-Poli", "given": "Paolo", "initials": "P"}, {"family": "Gorwood", "given": "Philip", "initials": "P"}, {"family": "Llorca", "given": "Pierre-Michel", "initials": "PM"}, {"family": "Krebs", "given": "Marie-Odile", "initials": "MO"}, {"family": "Scanferla", "given": "Elisabetta", "initials": "E"}, {"family": "Kishimoto", "given": "Taishiro", "initials": "T"}, {"family": "Rabbani", "given": "Golam", "initials": "G"}, {"family": "Skonieczna-\u017bydecka", "given": "Karolina", "initials": "K"}, {"family": "Brambilla", "given": "Paolo", "initials": "P"}, {"family": "Favaro", "given": "Angela", "initials": "A"}, {"family": "Takamiya", "given": "Akihiro", "initials": "A"}, {"family": "Zoccante", "given": "Leonardo", "initials": "L"}, {"family": "Colizzi", "given": "Marco", "initials": "M"}, {"family": "Bourgin", "given": "Julie", "initials": "J"}, {"family": "Kami\u0144ski", "given": "Karol", "initials": "K"}, {"family": "Moghadasin", "given": "Maryam", "initials": "M"}, {"family": "Seedat", "given": "Soraya", "initials": "S"}, {"family": "Matthews", "given": "Evan", "initials": "E"}, {"family": "Wells", "given": "John", "initials": "J"}, {"family": "Vassilopoulou", "given": "Emilia", "initials": "E"}, {"family": "Gadelha", "given": "Ary", "initials": "A"}, {"family": "Su", "given": "Kuan-Pin", "initials": "KP"}, {"family": "Kwon", "given": "Jun Soo", "initials": "JS"}, {"family": "Kim", "given": "Minah", "initials": "M"}, {"family": "Lee", "given": "Tae Young", "initials": "TY"}, {"family": "Papsuev", "given": "Oleg", "initials": "O"}, {"family": "Mankov\u00e1", "given": "Denisa", "initials": "D"}, {"family": "Boscutti", "given": "Andrea", "initials": "A"}, {"family": "Gerunda", "given": "Cristiano", "initials": "C"}, {"family": "Saccon", "given": "Diego", "initials": "D"}, {"family": "Righi", "given": "Elena", "initials": "E"}, {"family": "Monaco", "given": "Francesco", "initials": "F"}, {"family": "Croatto", "given": "Giovanni", "initials": "G"}, {"family": "Cereda", "given": "Guido", "initials": "G"}, {"family": "Demurtas", "given": "Jacopo", "initials": "J"}, {"family": "Brondino", "given": "Natascia", "initials": "N"}, {"family": "Veronese", "given": "Nicola", "initials": "N"}, {"family": "Enrico", "given": "Paolo", "initials": "P"}, {"family": "Politi", "given": "Pierluigi", "initials": "P"}, {"family": "Ciappolino", "given": "Valentina", "initials": "V"}, {"family": "Pfennig", "given": "Andrea", "initials": "A"}, {"family": "Bechdolf", "given": "Andreas", "initials": "A"}, {"family": "Meyer-Lindenberg", "given": "Andreas", "initials": "A"}, {"family": "Kahl", "given": "Kai G", "initials": "KG"}, {"family": "Domschke", "given": "Katharina", "initials": "K"}, {"family": "Bauer", "given": "Michael", "initials": "M"}, {"family": "Koutsouleris", "given": "Nikolaos", "initials": "N"}, {"family": "Winter", "given": "Sibylle", "initials": "S"}, {"family": "Borgwardt", "given": "Stefan", "initials": "S"}, {"family": "Bitter", "given": "Istvan", "initials": "I"}, {"family": "Balazs", "given": "Judit", "initials": "J"}, {"family": "Czobor", "given": "Pal", "initials": "P"}, {"family": "Unoka", "given": "Zsolt", "initials": "Z"}, {"family": "Mavridis", "given": "Dimitris", "initials": "D"}, {"family": "Tsamakis", "given": "Konstantinos", "initials": "K"}, {"family": "Bozikas", "given": "Vasilios P", "initials": "VP"}, {"family": "Tunvirachaisakul", "given": "Chavit", "initials": "C"}, {"family": "Maes", "given": "Michael", "initials": "M"}, {"family": "Rungnirundorn", "given": "Teerayuth", "initials": "T"}, {"family": "Supasitthumrong", "given": "Thitiporn", "initials": "T"}, {"family": "Haque", "given": "Ariful", "initials": "A"}, {"family": "Brunoni", "given": "Andre R", "initials": "AR"}, {"family": "Costardi", "given": "Carlos Gustavo", "initials": "CG"}, {"family": "Schuch", "given": "Felipe Barreto", "initials": "FB"}, {"family": "Polanczyk", "given": "Guilherme", "initials": "G"}, {"family": "Luiz", "given": "Jhoanne Merlyn", "initials": "JM"}, {"family": "Fonseca", "given": "Lais", "initials": "L"}, {"family": "Aparicio", "given": "Luana V", "initials": "LV"}, {"family": "Valvassori", "given": "Samira S", "initials": "SS"}, {"family": "Nordentoft", "given": "Merete", "initials": "M"}, {"family": "Vendsborg", "given": "Per", "initials": "P"}, {"family": "Hoffmann", "given": "Sofie Have", "initials": "SH"}, {"family": "Sehli", "given": "Jihed", "initials": "J"}, {"family": "Sartorius", "given": "Norman", "initials": "N"}, {"family": "Heuss", "given": "Sabina", "initials": "S"}, {"family": "Guinart", "given": "Daniel", "initials": "D"}, {"family": "Hamilton", "given": "Jane", "initials": "J"}, {"family": "Kane", "given": "John", "initials": "J"}, {"family": "Rubio", "given": "Jose", "initials": "J"}, {"family": "Sand", "given": "Michael", "initials": "M"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Solanes", "given": "Aleix", "initials": "A"}, {"family": "Andreu-Bernabeu", "given": "Alvaro", "initials": "A"}, {"family": "C\u00e1ceres", "given": "Antonia San Jos\u00e9", "initials": "ASJ"}, {"family": "Arango", "given": "Celso", "initials": "C"}, {"family": "D\u00edaz-Caneja", "given": "Covadonga M", "initials": "CM"}, {"family": "Hidalgo-Mazzei", "given": "Diego", "initials": "D"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Gonzalez-Pe\u00f1as", "given": "Javier", "initials": "J"}, {"family": "Fortea", "given": "Lydia", "initials": "L"}, {"family": "Parellada", "given": "Mara", "initials": "M"}, {"family": "Fullana", "given": "Miquel A", "initials": "MA"}, {"family": "Verdolini", "given": "Norma", "initials": "N"}, {"family": "F\u00e1rkov\u00e1", "given": "Eva", "initials": "E"}, {"family": "Jank\u016f", "given": "Karolina", "initials": "K"}, {"family": "Millan", "given": "Mark", "initials": "M"}, {"family": "Honciuc", "given": "Mihaela", "initials": "M"}, {"family": "Moniuszko-Malinowska", "given": "Anna", "initials": "A"}, {"family": "\u0141oniewski", "given": "Igor", "initials": "I"}, {"family": "Samochowiec", "given": "Jerzy", "initials": "J"}, {"family": "Kiszkiel", "given": "\u0141ukasz", "initials": "\u0141"}, {"family": "Marlicz", "given": "Maria", "initials": "M"}, {"family": "Sowa", "given": "Pawe\u0142", "initials": "P"}, {"family": "Marlicz", "given": "Wojciech", "initials": "W"}, {"family": "Spies", "given": "Georgina", "initials": "G"}, {"family": "Stubbs", "given": "Brendon", "initials": "B"}, {"family": "Firth", "given": "Joseph", "initials": "J"}, {"family": "Sullivan", "given": "Sarah", "initials": "S"}, {"family": "Darcin", "given": "Asli Enez", "initials": "AE"}, {"family": "Aksu", "given": "Hatice", "initials": "H"}, {"family": "Dilbaz", "given": "Nesrin", "initials": "N"}, {"family": "Noyan", "given": "Onur", "initials": "O"}, {"family": "Kitazawa", "given": "Momoko", "initials": "M"}, {"family": "Kurokawa", "given": "Shunya", "initials": "S"}, {"family": "Tazawa", "given": "Yuki", "initials": "Y"}, {"family": "Anselmi", "given": "Alejandro", "initials": "A"}, {"family": "Cracco", "given": "Cecilia", "initials": "C"}, {"family": "Machado", "given": "Ana In\u00e9s", "initials": "AI"}, {"family": "Estrade", "given": "Natalia", "initials": "N"}, {"family": "De Leo", "given": "Diego", "initials": "D"}, {"family": "Curtis", "given": "Jackie", "initials": "J"}, {"family": "Berk", "given": "Michael", "initials": "M"}, {"family": "Ward", "given": "Philip", "initials": "P"}, {"family": "Teasdale", "given": "Scott", "initials": "S"}, {"family": "Rosenbaum", "given": "Simon", "initials": "S"}, {"family": "Marx", "given": "Wolfgang", "initials": "W"}, {"family": "Horodnic", "given": "Adrian Vasile", "initials": "AV"}, {"family": "Oprea", "given": "Liviu", "initials": "L"}, {"family": "Alexinschi", "given": "Ovidiu", "initials": "O"}, {"family": "Ifteni", "given": "Petru", "initials": "P"}, {"family": "Turliuc", "given": "Serban", "initials": "S"}, {"family": "Ciuhodaru", "given": "Tudor", "initials": "T"}, {"family": "Bolos", "given": "Alexandra", "initials": "A"}, {"family": "Matei", "given": "Valentin", "initials": "V"}, {"family": "Nieman", "given": "Dorien H", "initials": "DH"}, {"family": "Sommer", "given": "Iris", "initials": "I"}, {"family": "van Os", "given": "Jim", "initials": "J"}, {"family": "van Amelsvoort", "given": "Therese", "initials": "T"}, {"family": "Sun", "given": "Ching-Fang", "initials": "CF"}, {"family": "Guu", "given": "Ta-Wei", "initials": "TW"}, {"family": "Jiao", "given": "Can", "initials": "C"}, {"family": "Zhang", "given": "Jieting", "initials": "J"}, {"family": "Fan", "given": "Jialin", "initials": "J"}, {"family": "Zou", "given": "Liye", "initials": "L"}, {"family": "Yu", "given": "Xin", "initials": "X"}, {"family": "Chi", "given": "Xinli", "initials": "X"}, {"family": "de Timary", "given": "Philippe", "initials": "P"}, {"family": "van Winke", "given": "Ruud", "initials": "R"}, {"family": "Ng", "given": "Bernardo", "initials": "B"}, {"family": "Pena", "given": "Edilberto", "initials": "E"}, {"family": "Arellano", "given": "Ramon", "initials": "R"}, {"family": "Roman", "given": "Raquel", "initials": "R"}, {"family": "Sanchez", "given": "Thelma", "initials": "T"}, {"family": "Movina", "given": "Larisa", "initials": "L"}, {"family": "Morgado", "given": "Pedro", "initials": "P"}, {"family": "Brissos", "given": "Sofia", "initials": "S"}, {"family": "Aizberg", "given": "Oleg", "initials": "O"}, {"family": "Mosina", "given": "Anna", "initials": "A"}, {"family": "Krinitski", "given": "Damir", "initials": "D"}, {"family": "Mugisha", "given": "James", "initials": "J"}, {"family": "Sadeghi-Bahmani", "given": "Dena", "initials": "D"}, {"family": "Sadeghi", "given": "Masoud", "initials": "M"}, {"family": "Hadi", "given": "Samira", "initials": "S"}, {"family": "Brand", "given": "Serge", "initials": "S"}, {"family": "Errazuriz", "given": "Antonia", "initials": "A"}, {"family": "Crossley", "given": "Nicolas", "initials": "N"}, {"family": "Ristic", "given": "Dragana Ignjatovic", "initials": "DI"}, {"family": "L\u00f3pez-Jaramillo", "given": "Carlos", "initials": "C"}, {"family": "Efthymiou", "given": "Dimitris", "initials": "D"}, {"family": "Kuttichira", "given": "Praveenlal", "initials": "P"}, {"family": "Kallivayalil", "given": "Roy Abraham", "initials": "RA"}, {"family": "Javed", "given": "Afzal", "initials": "A"}, {"family": "Afridi", "given": "Muhammad Iqbal", "initials": "MI"}, {"family": "James", "given": "Bawo", "initials": "B"}, {"family": "Seb-Akahomen", "given": "Omonefe Joy", "initials": "OJ"}, {"family": "Fiedorowicz", "given": "Jess", "initials": "J"}, {"family": "Carvalho", "given": "Andre F", "initials": "AF"}, {"family": "Daskalakis", "given": "Jeff", "initials": "J"}, {"family": "Yatham", "given": "Lakshmi N", "initials": "LN"}, {"family": "Yang", "given": "Lin", "initials": "L"}, {"family": "Okasha", "given": "Tarek", "initials": "T"}, {"family": "Dahdouh", "given": "A\u00efcha", "initials": "A"}, {"family": "Gerdle", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Tiihonen", "given": "Jari", "initials": "J"}, {"family": "Shin", "given": "Jae Il", "initials": "JI"}, {"family": "Lee", "given": "Jinhee", "initials": "J"}, {"family": "Mhalla", "given": "Ahmed", "initials": "A"}, {"family": "Gaha", "given": "Lotfi", "initials": "L"}, {"family": "Brahim", "given": "Takoua", "initials": "T"}, {"family": "Altynbekov", "given": "Kuanysh", "initials": "K"}, {"family": "Negay", "given": "Nikolay", "initials": "N"}, {"family": "Nurmagambetova", "given": "Saltanat", "initials": "S"}, {"family": "Jamei", "given": "Yasser Abu", "initials": "YA"}, {"family": "Weiser", "given": "Mark", "initials": "M"}, {"family": "Correll", "given": "Christoph U", "initials": "CU"}], "type": "journal article", "published": "2021-07-19", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "volume": "299", "pages": "393-407", "issn-l": null}, "abstract": ". High-quality comprehensive data on short-/long-term physical/mental health effects of the COVID-19 pandemic are needed.\n\n. The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) is an international, multi-language (n=30) project involving >230 investigators from 49 countries/territories/regions, endorsed by national/international professional associations. COH-FIT is a multi-wave, on-line anonymous, cross-sectional survey [wave 1: 04/2020 until the end of the pandemic, 12 months waves 2/3 starting 6/24 months threreafter] for adults, adolescents (14-17), and children (6-13), utilizing non-probability/snowball and representative sampling. COH-FIT aims to identify non-modifiable/modifiable risk factors/treatment targets to inform prevention/intervention programs to improve social/health outcomes in the general population/vulnerable subgrous during/after COVID-19. In adults, co-primary outcomes are change from pre-COVID-19 to intra-COVID-19 in well-being (WHO-5) and a composite psychopathology P-Score. Key secondary outcomes are a P-extended score, global mental and physical health. Secondary outcomes include health-service utilization/functioning, treatment adherence, functioning, symptoms/behaviors/emotions, substance use, violence, among others.\n\n. Starting 04/26/2020, up to 14/07/2021 >151,000 people from 155 countries/territories/regions and six continents have participated. Representative samples of \u22651,000 adults have been collected in 15 countries. Overall, 43.0% had prior physical disorders, 16.3% had prior mental disorders, 26.5% were health care workers, 8.2% were aged \u226565 years, 19.3% were exposed to someone infected with COVID-19, 76.1% had been in quarantine, and 2.1% had been COVID 19-positive.\n\n. Cross-sectional survey, preponderance of non-representative participants.\n\n. Results from COH-FIT will comprehensively quantify the impact of COVID-19, seeking to identify high-risk groups in need for acute and long-term intervention, and inform evidence-based health policies/strategies during this/future pandemics.", "doi": "10.1016/j.jad.2021.07.048", "pmid": "34949568", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0165-0327(21)00727-8"}, {"db": "pmc", "key": "PMC8288233"}], "notes": [], "created": "2022-01-04T15:28:29.970Z", "modified": "2022-01-04T15:28:38.000Z"}, {"entity": "publication", "iuid": "63c8ec3fd14f4ad59f7b63fdef28e761", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63c8ec3fd14f4ad59f7b63fdef28e761.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63c8ec3fd14f4ad59f7b63fdef28e761"}}, "title": "Systematic evaluation of SARS-CoV-2 antigens enables a highly specific and sensitive multiplex serological COVID-19 assay.", "authors": [{"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc2c612e12284831866002f6759932d5.json"}}, {"family": "Andersson", "given": "Eni", "initials": "E", "orcid": "0000-0002-5115-0637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8200b399e954f3482aec53a62df3b54.json"}}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/282479e5be7c453691d5be4847018b01.json"}}, {"family": "Jernbom Falk", "given": "August", "initials": "A", "orcid": "0000-0002-7773-1851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40d944d7fa964f4292f10012356a2730.json"}}, {"family": "Bayati", "given": "Shaghayegh", "initials": "S"}, {"family": "Mravinacova", "given": "Sara", "initials": "S"}, {"family": "Sj\u00f6berg", "given": "Ronald", "initials": "R", "orcid": "0000-0003-1363-5796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/88fa4197c91348bdb1933006a947a9d1.json"}}, {"family": "Yousef", "given": "Jamil", "initials": "J", "orcid": "0000-0001-5915-1258", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/324e111715fc4029badd136232057025.json"}}, {"family": "Skoglund", "given": "Lovisa", "initials": "L"}, {"family": "Kanje", "given": "Sara", "initials": "S"}, {"family": "Berling", "given": "Anna", "initials": "A"}, {"family": "Svensson", "given": "Anne-Sophie", "initials": "AS"}, {"family": "Jensen", "given": "Gabriella", "initials": "G"}, {"family": "Enstedt", "given": "Henric", "initials": "H"}, {"family": "Afshari", "given": "Delaram", "initials": "D"}, {"family": "Xu", "given": "Lan Lan", "initials": "LL"}, {"family": "Zwahlen", "given": "Martin", "initials": "M"}, {"family": "von Feilitzen", "given": "Kalle", "initials": "K"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Lendel", "given": "Christofer", "initials": "C"}, {"family": "Roth", "given": "Robert G", "initials": "RG"}, {"family": "Skoog", "given": "Ingmar", "initials": "I"}, {"family": "Svenungsson", "given": "Elisabet", "initials": "E"}, {"family": "Olsson", "given": "Tomas", "initials": "T"}, {"family": "Fogdell-Hahn", "given": "Anna", "initials": "A"}, {"family": "Lindroth", "given": "Ylva", "initials": "Y"}, {"family": "Lundgren", "given": "Maria", "initials": "M"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Lagerqvist", "given": "Nina", "initials": "N"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Da Silva Rodrigues", "given": "Rui", "initials": "R"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Arroyo M\u00fchr", "given": "Laila Sara", "initials": "LS"}, {"family": "Eklund", "given": "Carina", "initials": "C"}, {"family": "Lagheden", "given": "Camilla", "initials": "C"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Sivertsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f28f2f6ac9648629c2d2de92fe7bb59.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1345-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a53a433db6f04a458e3d420f0c9995c5.json"}}, {"family": "Tegel", "given": "Hanna", "initials": "H", "orcid": "0000-0002-7067-9173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d3fde7ee5de4dab899746becfae364d.json"}}, {"family": "Pin", "given": "Elisa", "initials": "E", "orcid": "0000-0002-2158-2674", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5568b1a9e3c456c8ee4a95eaa55b103.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c735ef404391493980e4e51d70459ce0.json"}}, {"family": "Hedhammar", "given": "My", "initials": "M", "orcid": "0000-0003-0140-419X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/762482db3e014ccc94527d9e71816c80.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}], "type": "journal article", "published": "2021-07-19", "journal": {"title": "Clin Transl Immunol", "issn": "2050-0068", "issn-l": null, "volume": "10", "issue": "7", "pages": "e1312"}, "abstract": "The COVID-19 pandemic poses an immense need for accurate, sensitive and high-throughput clinical tests, and serological assays are needed for both overarching epidemiological studies and evaluating vaccines. Here, we present the development and validation of a high-throughput multiplex bead-based serological assay.\n\nMore than 100 representations of SARS-CoV-2 proteins were included for initial evaluation, including antigens produced in bacterial and mammalian hosts as well as synthetic peptides. The five best-performing antigens, three representing the spike glycoprotein and two representing the nucleocapsid protein, were further evaluated for detection of IgG antibodies in samples from 331 COVID-19 patients and convalescents, and in 2090 negative controls sampled before 2020.\n\nThree antigens were finally selected, represented by a soluble trimeric form and the S1-domain of the spike glycoprotein as well as by the C-terminal domain of the nucleocapsid. The sensitivity for these three antigens individually was found to be 99.7%, 99.1% and 99.7%, and the specificity was found to be 98.1%, 98.7% and 95.7%. The best assay performance was although achieved when utilising two antigens in combination, enabling a sensitivity of up to 99.7% combined with a specificity of 100%. Requiring any two of the three antigens resulted in a sensitivity of 99.7% and a specificity of 99.4%.\n\nThese observations demonstrate that a serological test based on a combination of several SARS-CoV-2 antigens enables a highly specific and sensitive multiplex serological COVID-19 assay.", "doi": "10.1002/cti2.1312", "pmid": "34295471", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Biobanks for COVID-19 research": null, "Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC8288725"}, {"db": "pii", "key": "CTI21312"}], "notes": [], "created": "2021-08-05T07:13:34.602Z", "modified": "2023-06-19T14:23:26.622Z"}, {"entity": "publication", "iuid": "dda9ad76bb694baa8956651c2effe465", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dda9ad76bb694baa8956651c2effe465.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dda9ad76bb694baa8956651c2effe465"}}, "title": "Subjective mental health and need for care among psychiatric outpatients during the COVID-19 pandemic: Results from an outreach initiative in Sweden.", "authors": [{"family": "Flygare", "given": "Oskar", "initials": "O"}, {"family": "Ivanov", "given": "Volen Z", "initials": "VZ"}, {"family": "S\u00e4ll", "given": "Roland", "initials": "R"}, {"family": "Malaise", "given": "Henrik", "initials": "H"}, {"family": "Ivanova", "given": "Ekaterina", "initials": "E"}, {"family": "R\u00fcck", "given": "Christian", "initials": "C"}, {"family": "Jayaram-Lindstr\u00f6m", "given": "Nitya", "initials": "N"}, {"family": "Martinsson", "given": "Lina", "initials": "L"}], "type": "letter", "published": "2021-07-19", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "volume": "304", "pages": "114124", "issn-l": null}, "abstract": null, "doi": "10.1016/j.psychres.2021.114124", "pmid": "34303944", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(21)00420-0"}, {"db": "pmc", "key": "PMC8288212"}], "notes": [], "created": "2021-08-05T07:03:46.909Z", "modified": "2021-08-05T07:03:46.923Z"}, {"entity": "publication", "iuid": "d7e3f2a78e54439bba3157456d2ec4bc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d7e3f2a78e54439bba3157456d2ec4bc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d7e3f2a78e54439bba3157456d2ec4bc"}}, "title": "Real-time monitoring of COVID-19 dynamics using automated trend fitting and anomaly detection.", "authors": [{"family": "Jombart", "given": "Thibaut", "initials": "T"}, {"family": "Ghozzi", "given": "St\u00e9phane", "initials": "S"}, {"family": "Schumacher", "given": "Dirk", "initials": "D"}, {"family": "Taylor", "given": "Timothy J", "initials": "TJ"}, {"family": "Leclerc", "given": "Quentin J", "initials": "QJ"}, {"family": "Jit", "given": "Mark", "initials": "M"}, {"family": "Flasche", "given": "Stefan", "initials": "S"}, {"family": "Greaves", "given": "Felix", "initials": "F"}, {"family": "Ward", "given": "Tom", "initials": "T"}, {"family": "Eggo", "given": "Rosalind M", "initials": "RM"}, {"family": "Nightingale", "given": "Emily", "initials": "E"}, {"family": "Meakin", "given": "Sophie", "initials": "S"}, {"family": "Brady", "given": "Oliver J", "initials": "OJ"}, {"family": "Centre for Mathematical Modelling of Infectious Diseases COVID-19 Working Group", "given": "", "initials": ""}, {"family": "Medley", "given": "Graham F", "initials": "GF"}, {"family": "H\u00f6hle", "given": "Michael", "initials": "M"}, {"family": "Edmunds", "given": "W John", "initials": "WJ"}], "type": "journal article", "published": "2021-07-19", "journal": {"title": "Philos Trans R Soc Lond B Biol Sci", "issn": "1471-2970", "volume": "376", "issue": "1829", "pages": "20200266", "issn-l": null}, "abstract": "As several countries gradually release social distancing measures, rapid detection of new localized COVID-19 hotspots and subsequent intervention will be key to avoiding large-scale resurgence of transmission. We introduce ASMODEE (automatic selection of models and outlier detection for epidemics), a new tool for detecting sudden changes in COVID-19 incidence. Our approach relies on automatically selecting the best (fitting or predicting) model from a range of user-defined time series models, excluding the most recent data points, to characterize the main trend in an incidence. We then derive prediction intervals and classify data points outside this interval as outliers, which provides an objective criterion for identifying departures from previous trends. We also provide a method for selecting the optimal breakpoints, used to define how many recent data points are to be excluded from the trend fitting procedure. The analysis of simulated COVID-19 outbreaks suggests ASMODEE compares favourably with a state-of-art outbreak-detection algorithm while being simpler and more flexible. As such, our method could be of wider use for infectious disease surveillance. We illustrate ASMODEE using publicly available data of National Health Service (NHS) Pathways reporting potential COVID-19 cases in England at a fine spatial scale, showing that the method would have enabled the early detection of the flare-ups in Leicester and Blackburn with Darwen, two to three weeks before their respective lockdown. ASMODEE is implemented in the free R package trendbreaker. This article is part of the theme issue 'Modelling that shaped the early COVID-19 pandemic response in the UK'.", "doi": "10.1098/rstb.2020.0266", "pmid": "34053271", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-06-04T11:31:18.924Z", "modified": "2021-06-04T11:31:18.946Z"}, {"entity": "publication", "iuid": "121c037fbfa3422092e67e3883f756e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/121c037fbfa3422092e67e3883f756e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/121c037fbfa3422092e67e3883f756e2"}}, "title": "COVID-19 in liver transplant candidates: pretransplant and post-transplant outcomes - an ELITA/ELTR multicentre cohort study.", "authors": [{"family": "Belli", "given": "Luca Saverio", "initials": "LS", "orcid": "0000-0001-8714-2439", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1f6c6e519814fc6b8bf380a6589f41e.json"}}, {"family": "Duvoux", "given": "Christophe", "initials": "C"}, {"family": "Cortesi", "given": "Paolo Angelo", "initials": "PA", "orcid": "0000-0001-5241-4473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24fb5550c396431ba1690caeb044c89c.json"}}, {"family": "Facchetti", "given": "Rita", "initials": "R"}, {"family": "Iacob", "given": "Speranta", "initials": "S"}, {"family": "Perricone", "given": "Giovanni", "initials": "G", "orcid": "0000-0003-3890-5393", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a3f2d16c96f4f9bb38a55d4e9e18921.json"}}, {"family": "Radenne", "given": "Sylvie", "initials": "S"}, {"family": "Conti", "given": "Sara", "initials": "S"}, {"family": "Patrono", "given": "Damiano", "initials": "D"}, {"family": "Berlakovich", "given": "Gabriela", "initials": "G"}, {"family": "Hann", "given": "Angus", "initials": "A"}, {"family": "Pasulo", "given": "Luisa", "initials": "L"}, {"family": "Castells", "given": "Lluis", "initials": "L"}, {"family": "Faitot", "given": "Francois", "initials": "F"}, {"family": "Detry", "given": "Olivier", "initials": "O"}, {"family": "Invernizzi", "given": "Federica", "initials": "F"}, {"family": "Magini", "given": "Giulia", "initials": "G"}, {"family": "De Simone", "given": "Paolo", "initials": "P"}, {"family": "Kounis", "given": "Ilias", "initials": "I", "orcid": "0000-0003-3876-2097", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00c977ccd8c541e29f5e2466104bda51.json"}}, {"family": "Morelli", "given": "Maria Cristina", "initials": "MC"}, {"family": "D\u00edaz Fontenla", "given": "Fernando", "initials": "F", "orcid": "0000-0002-4700-0281", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9252ae5865e4e6087766dee75e72d43.json"}}, {"family": "Ericzon", "given": "Bo-G\u00f6ran", "initials": "BG"}, {"family": "Loinaz", "given": "Carmelo", "initials": "C"}, {"family": "Johnston", "given": "Chris", "initials": "C"}, {"family": "Gheorghe", "given": "Liliana", "initials": "L"}, {"family": "Lesurtel", "given": "Mickael", "initials": "M"}, {"family": "Romagnoli", "given": "Renato", "initials": "R", "orcid": "0000-0001-8340-8885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd3f53ab108b4c2e93da4a127460010d.json"}}, {"family": "Kollmann", "given": "Dagmar", "initials": "D"}, {"family": "Perera", "given": "M Thamara Pr", "initials": "MTP"}, {"family": "Fagiuoli", "given": "Stefano", "initials": "S"}, {"family": "Mirza", "given": "Darius", "initials": "D"}, {"family": "Coilly", "given": "Audrey", "initials": "A"}, {"family": "Toso", "given": "Christian", "initials": "C"}, {"family": "Zieniewicz", "given": "Krzysztof", "initials": "K"}, {"family": "Elkrief", "given": "Laure", "initials": "L"}, {"family": "Karam", "given": "Vincent", "initials": "V"}, {"family": "Adam", "given": "Rene", "initials": "R"}, {"family": "den Hoed", "given": "Caroline", "initials": "C"}, {"family": "Merli", "given": "Marco", "initials": "M"}, {"family": "Puoti", "given": "Massimo", "initials": "M"}, {"family": "De Carlis", "given": "Luciano", "initials": "L"}, {"family": "Oniscu", "given": "Gabriel C", "initials": "GC"}, {"family": "Piano", "given": "Salvatore", "initials": "S"}, {"family": "Angeli", "given": "Paolo", "initials": "P", "orcid": "0000-0002-1913-0716", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a88accb32a24526a946dcfa6394f23c.json"}}, {"family": "Fondevila", "given": "Constantino", "initials": "C"}, {"family": "Polak", "given": "Wojciech G", "initials": "WG"}, {"family": "for all the centres contributing to the ELITA-ELTR COVID-19 Registry", "given": "", "initials": ""}], "type": "journal article", "published": "2021-07-19", "journal": {"title": "Gut", "issn": "1468-3288", "issn-l": null}, "abstract": "Explore the impact of COVID-19 on patients on the waiting list for liver transplantation (LT) and on their post-LT course.\n\nData from consecutive adult LT candidates with COVID-19 were collected across Europe in a dedicated registry and were analysed.\n\nFrom 21 February to 20 November 2020, 136 adult cases with laboratory-confirmed SARS-CoV-2 infection from 33 centres in 11 European countries were collected, with 113 having COVID-19. Thirty-seven (37/113, 32.7%) patients died after a median of 18 (10-30) days, with respiratory failure being the major cause (33/37, 89.2%). The 60-day mortality risk did not significantly change between first (35.3%, 95% CI 23.9% to 50.0%) and second (26.0%, 95% CI 16.2% to 40.2%) waves. Multivariable Cox regression analysis showed Laboratory Model for End-stage Liver Disease (Lab-MELD) score of \u226515 (Model for End-stage Liver Disease (MELD) score 15-19, HR 5.46, 95% CI 1.81 to 16.50; MELD score\u226520, HR 5.24, 95% CI 1.77 to 15.55) and dyspnoea on presentation (HR 3.89, 95% CI 2.02 to 7.51) being the two negative independent factors for mortality. Twenty-six patients underwent an LT after a median time of 78.5 (IQR 44-102) days, and 25 (96%) were alive after a median follow-up of 118 days (IQR 31-170).\n\nIncreased mortality in LT candidates with COVID-19 (32.7%), reaching 45% in those with decompensated cirrhosis (DC) and Lab-MELD score of \u226515, was observed, with no significant difference between first and second waves of the pandemic. Respiratory failure was the major cause of death. The dismal prognosis of patients with DC supports the adoption of strict preventative measures and the urgent testing of vaccination efficacy in this population. Prior SARS-CoV-2 symptomatic infection did not affect early post-transplant survival (96%).", "doi": "10.1136/gutjnl-2021-324879", "pmid": "34281984", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "gutjnl-2021-324879"}, {"db": "pmc", "key": "PMC8300535"}], "notes": [], "created": "2021-08-05T11:11:29.008Z", "modified": "2021-08-05T11:11:41.499Z"}, {"entity": "publication", "iuid": "d3d37c8fc405417291432990e06c4214", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3d37c8fc405417291432990e06c4214.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3d37c8fc405417291432990e06c4214"}}, "title": "The effectiveness of psychological interventions for loneliness: A systematic review and meta-analysis.", "authors": [{"family": "Hickin", "given": "Nisha", "initials": "N"}, {"family": "K\u00e4ll", "given": "Anton", "initials": "A"}, {"family": "Shafran", "given": "Roz", "initials": "R"}, {"family": "Sutcliffe", "given": "Sebastian", "initials": "S"}, {"family": "Manzotti", "given": "Grazia", "initials": "G"}, {"family": "Langan", "given": "Dean", "initials": "D"}], "type": "journal article", "published": "2021-07-18", "journal": {"title": "Clin Psychol Rev", "issn": "1873-7811", "volume": "88", "pages": "102066", "issn-l": null}, "abstract": "Chronic loneliness is associated with a range of mental health difficulties. Previous theory and research indicate that psychological interventions show promise for reducing loneliness, however, there have been no systematic reviews or meta-analyses to ascertain the efficacy of these interventions across the lifespan. The aim of this study was to synthesise, meta-analyse and explore the heterogeneity in RCTs of psychological interventions for loneliness in order to establish their efficacy. Five databases (Ovid Embase, Ovid Medline, PsycINFO, Web of Science and CINAHL) were systematically searched in order to identify relevant studies. Included studies were required to be peer-reviewed RCTs examining psychological interventions for loneliness. Two independent coders examined the abstracts of the 3973 studies and 103 full texts, finding 31 studies that met inclusion criteria, 28 of which contained sufficient statistical information to be included in the meta-analysis. The quality of included studies was assessed using the Cochrane Risk of Bias Tool. The 31 studies (N = 3959) that were included in the systematic review were conducted with participants from a diverse range of cultures, age groups and populations. The interventions were of mixed quality and were mostly face to face, group-based and delivered weekly. The most common type of intervention was Cognitive Behavioural Therapy (CBT). 28 studies (N = 3039) were included in a meta-analysis which found that psychological interventions significantly reduced loneliness compared to control groups, yielding a small to medium effect size (g = 0.43). Subgroup analysis and meta-regressions were conducted in order to explore heterogeneity and found that type of psychological intervention was approaching significance as a moderator of the effectiveness of psychological interventions for loneliness. In conclusion, psychological interventions for loneliness across the lifespan are effective. This finding should inform policy makers, researchers and clinicians going forward, especially in the context of increased loneliness due to the COVID-19 pandemic. There was considerable heterogeneity in the effectiveness of the interventions, suggesting that future research should also explore what works for whom and consider personalising psychological treatment.", "doi": "10.1016/j.cpr.2021.102066", "pmid": "34339939", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0272-7358(21)00109-4"}], "notes": [], "created": "2021-08-04T10:10:30.940Z", "modified": "2021-08-04T10:10:30.963Z"}, {"entity": "publication", "iuid": "1ddcdc9140bb4536be76b2b64bf7cf2c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ddcdc9140bb4536be76b2b64bf7cf2c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ddcdc9140bb4536be76b2b64bf7cf2c"}}, "title": "Thrombocytopenia with acute ischemic stroke and bleeding in a patient newly vaccinated with an adenoviral vector-based COVID-19 vaccine: COMMENT: COMMENT from Gruel et al.: RESPONSE from Kahn et al.", "authors": [{"family": "Kahn", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-5566-6350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42eda71f3775400599febc10a4e7359c.json"}}, {"family": "Shannon", "given": "Oongh", "initials": "O", "orcid": "0000-0001-8291-8189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7fad6031e2f4a84a8ede77911d3c542.json"}}, {"family": "Bj\u00f6rck", "given": "Lars", "initials": "L"}], "type": "letter", "published": "2021-07-17", "journal": {"title": "J Thromb Haemost", "issn": "1538-7836", "issn-l": null}, "abstract": "We acknowledge the commentary of Gruel et al. on our recent letter [1] and are pleased that the authors agree that IdeS may be a potential treatment option for the rare but potentially severe IgG-mediated platelet activation observed in complications to vaccination with ChAdOx1 nCoV-19. It is apparent that our respective but distinct expertise with regard to IdeS has led us to develop this hypothesis in parallel. As we clearly cited in our original letter these authors have previously contributed important evidence that IdeS may be beneficial in treating IgG-mediated platelet dysfunction in a mouse model of heparin induced thrombocytopenia [2]. The intention with our letter was to provide more background to IdeS and insight into the unique properties of IdeS that make it suitable for treating many manifestations of IgG-mediated human disease.", "doi": "10.1111/jth.15467", "pmid": "34273222", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:14:15.858Z", "modified": "2021-08-06T07:14:15.903Z"}, {"entity": "publication", "iuid": "8f61ddc00ca64be98849030ad2120659", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f61ddc00ca64be98849030ad2120659.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f61ddc00ca64be98849030ad2120659"}}, "title": "Psychosocial experiences of frontline nurses working in hospital-based settings during the COVID-19 pandemic - A qualitative systematic review.", "authors": [{"family": "Xu", "given": "Hongxuan", "initials": "H"}, {"family": "Stjernsw\u00e4rd", "given": "Sigrid", "initials": "S"}, {"family": "Glasdam", "given": "Stinne", "initials": "S"}], "type": "journal article", "published": "2021-07-17", "journal": {"title": "Int J Nurs Stud Adv", "issn": "2666-142X", "pages": "100037", "issn-l": null}, "abstract": "Frontline nurses have been directly exposed to the SARS-CoV-2 virus and come in close contact with patients during the COVID-19 pandemic. Nurses endorse tasks related to disease control and face multiple psychosocial challenges in their frontline work, potentially affecting their mental well-being and ability to satisfyingly perform their tasks.\n\nTo explore the psychosocial experiences of frontline nurses working in hospital-based settings during the COVID-19 pandemic.\n\nThe qualitative systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. Registered in PROSPERO (CRD42021259111).\n\nLiterature searches were performed through PubMed, CINAHL, and the WHO COVID-19 database. Inclusion criteria were: All types of nurses having direct contact with or taking care of patients; Primary, secondary, and tertiary health-care services admitting and treating COVID-19 patients; Experiences, perceptions, feelings, views in psychosocial aspects from the identified population group; Qualitative studies; Mixed methods studies; Language in English; Published date 2019-2021. Exclusion criteria were: Commentaries; Reviews; Discussion papers; Quantitative studies; Language other than English; Published in 2018 or earlier; Studies without an ethical approval and ethical statement.\n\nThe studies were screened and selected based on the inclusion and exclusion criteria. Quality appraisal was conducted according to the Critical Appraisal Skills Program qualitative study checklist. Data was extracted from included studies and a thematic synthesis was made.\n\nA total of 28 studies were included in the review. The experiences of 1141 nurses from 12 countries were synthesised. Four themes were constructed: 'Nurses' emotional, mental and physical reactions to COVID-19', 'A mix of environmental and personal stressors', 'Internally and externally supported coping strategies', and 'A call for future help and support'.\n\nNurses working frontline during the COVID-19 pandemic have experienced psychological, social, and emotional distress in coping with work demands, social relationships, and their personal life. The results pointed to a need for increased psychological and social support for frontline nurses to cope with stress and maintain mental well-being, which may subsequently affect nursing care outcomes.", "doi": "10.1016/j.ijnsa.2021.100037", "pmid": "34308373", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2666-142X(21)00019-9"}, {"db": "pmc", "key": "PMC8285218"}], "notes": [], "created": "2021-08-05T06:53:13.301Z", "modified": "2021-08-05T06:53:13.329Z"}, {"entity": "publication", "iuid": "1c9b866f37de4b0eb739038e2bd2420e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1c9b866f37de4b0eb739038e2bd2420e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1c9b866f37de4b0eb739038e2bd2420e"}}, "title": "COVID-19: counting migrants in.", "authors": [{"family": "Hargreaves", "given": "Sally", "initials": "S"}, {"family": "Hayward", "given": "Sally E", "initials": "SE"}, {"family": "Noori", "given": "Teymur", "initials": "T"}, {"family": "McKee", "given": "Martin", "initials": "M"}, {"family": "Kumar", "given": "Bernadette", "initials": "B"}], "type": "letter", "published": "2021-07-17", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "398", "issue": "10296", "pages": "211-212", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(21)01339-8", "pmid": "34274061", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)01339-8"}, {"db": "pmc", "key": "PMC8285119"}], "notes": [], "created": "2021-08-06T07:13:37.646Z", "modified": "2021-08-06T07:13:37.649Z"}, {"entity": "publication", "iuid": "ff1ecc2c6bd54e4a808421774175fd27", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff1ecc2c6bd54e4a808421774175fd27.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff1ecc2c6bd54e4a808421774175fd27"}}, "title": "The mechanism behind flaring/triggering of autoimmunity disorders associated with COVID-19.", "authors": [{"family": "Redwan", "given": "Elrashdy M", "initials": "EM"}, {"family": "Alghamdi", "given": "Mohammed F", "initials": "MF"}, {"family": "El-Aziz", "given": "Tarek Mohamed Abd", "initials": "TMA"}, {"family": "Adadi", "given": "Parise", "initials": "P"}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA"}, {"family": "Attrish", "given": "Diksha", "initials": "D"}, {"family": "Azad", "given": "Gajendra Kumar", "initials": "GK"}, {"family": "Baetas-da-Cruz", "given": "Wagner", "initials": "W"}, {"family": "Barh", "given": "Debmalya", "initials": "D"}, {"family": "Bazan", "given": "Nicolas G", "initials": "NG"}, {"family": "Brufsky", "given": "Adam M", "initials": "AM"}, {"family": "Chauhan", "given": "Gaurav", "initials": "G"}, {"family": "Hassan", "given": "S K Sarif", "initials": "SKS"}, {"family": "Kandimalla", "given": "Ramesh", "initials": "R"}, {"family": "Lal", "given": "Amos", "initials": "A"}, {"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Mishra", "given": "Yogendra Kumar", "initials": "YK"}, {"family": "Choudhury", "given": "Pabitra Pal", "initials": "PP"}, {"family": "Pal\u00f9", "given": "Giorgio", "initials": "G"}, {"family": "Panda", "given": "Pritam K", "initials": "PK"}, {"family": "Pizzol", "given": "Damiano", "initials": "D"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Serrano-Aroca", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Seyran", "given": "Murat", "initials": "M"}, {"family": "Takayama", "given": "Kazuo", "initials": "K"}, {"family": "Tambuwala", "given": "Murtaza M", "initials": "MM"}, {"family": "Uhal", "given": "Bruce D", "initials": "BD"}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN"}], "type": "letter", "published": "2021-07-16", "journal": {"title": "Autoimmun Rev", "issn": "1873-0183", "volume": "20", "issue": "10", "pages": "102909", "issn-l": null}, "abstract": null, "doi": "10.1016/j.autrev.2021.102909", "pmid": "34274539", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1568-9972(21)00184-1"}, {"db": "pmc", "key": "PMC8282442"}], "notes": [], "created": "2021-08-05T11:15:20.688Z", "modified": "2021-08-05T11:15:33.836Z"}, {"entity": "publication", "iuid": "9628f3c7ffc54d9a9f25a4b79e80675e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9628f3c7ffc54d9a9f25a4b79e80675e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9628f3c7ffc54d9a9f25a4b79e80675e"}}, "title": "Impacts of the COVID-19 epidemic on the department of stomatology in a tertiary hospital: A case study in the General Hospital of the Central Theater Command, Wuhan, China.", "authors": [{"family": "Dong", "given": "Qingshan", "initials": "Q"}, {"family": "Kuria", "given": "Angelica", "initials": "A"}, {"family": "Weng", "given": "Yanming", "initials": "Y"}, {"family": "Liu", "given": "Yu", "initials": "Y"}, {"family": "Cao", "given": "Yang", "initials": "Y", "orcid": "0000-0002-3552-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7594ca0fdf2d4f238ca04a788a405cdb.json"}}], "type": "journal article", "published": "2021-07-16", "journal": {"title": "Community Dent Oral Epidemiol", "issn": "1600-0528", "issn-l": null}, "abstract": "The impact of the worldwide COVID-19 pandemic on the dental community is evident. Dental education programmes and academic activities have suffered from the ramifications of the pandemic. This study aimed to depict the impacts of the COVID-19 epidemic on the clinical services and academic activities in the department of stomatology of a tertiary hospital in Wuhan, China.\n\nWe obtained historical data of the Department of Stomatology from the Health Information System of the General Hospital of Central Theater Command, Wuhan, China between January 2018 and June 2020. Mean, standard deviation and median with interquartile range were used to summarize the variables. Line plots were used to illustrate the temporal trend. The Kruskal-Wallis equality-of-populations rank test was used to compare the difference between groups.\n\nA significant decrease was noted in the monthly average number of patients seeking outpatient services for the year 2020, which were decreased by two-thirds from 2018 to 2020. The number of emergency cases also decreased significantly by 57.6% in 2020. The monthly number of teaching hours decreased from 3.8 \u00b1 1.5 in 2018 and 4.7 \u00b1 1.4 in 2019 to 1.7 \u00b1 1.9 in 2020. The number of interns also decreased by more than 77.0% in 2020.\n\nThe impacts of COVID-19 in the stomatology clinic were significant with notable decreases in clinical services and education offered to the stomatology students. There is a need to find solutions to keep as many dental professionals as needed remaining on the frontline of oral health care.", "doi": "10.1111/cdoe.12680", "pmid": "34270106", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:15:46.033Z", "modified": "2021-08-06T07:15:46.092Z"}, {"entity": "publication", "iuid": "7a85e9c9d7584294bc016757ec2c0457", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a85e9c9d7584294bc016757ec2c0457.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a85e9c9d7584294bc016757ec2c0457"}}, "title": "COVID-19: the turning point for gender equality.", "authors": [{"family": "Fisseha", "given": "Senait", "initials": "S"}, {"family": "Sen", "given": "Gita", "initials": "G"}, {"family": "Ghebreyesus", "given": "Tedros Adhanom", "initials": "TA"}, {"family": "Byanyima", "given": "Winnie", "initials": "W"}, {"family": "Diniz", "given": "Debora", "initials": "D"}, {"family": "Fore", "given": "Henrietta H", "initials": "HH"}, {"family": "Kanem", "given": "Natalia", "initials": "N"}, {"family": "Karlsson", "given": "Ulrika", "initials": "U"}, {"family": "Khosla", "given": "Rajat", "initials": "R"}, {"family": "Laski", "given": "Laura", "initials": "L"}, {"family": "Mired", "given": "Dina", "initials": "D"}, {"family": "Mlambo-Ngcuka", "given": "Phumzile", "initials": "P"}, {"family": "Mofokeng", "given": "Tlaleng", "initials": "T"}, {"family": "Gupta", "given": "Geeta Rao", "initials": "GR"}, {"family": "Steiner", "given": "Achim", "initials": "A"}, {"family": "Remme", "given": "Michelle", "initials": "M"}, {"family": "Allotey", "given": "Pascale", "initials": "P"}], "type": "journal article", "published": "2021-07-16", "journal": {"title": "Lancet", "issn": "1474-547X", "issn-l": "0140-6736", "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/S0140-6736(21)01651-2", "pmid": "34280381", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)01651-2"}], "notes": [], "created": "2021-08-05T11:12:05.803Z", "modified": "2022-11-23T08:55:18.950Z"}, {"entity": "publication", "iuid": "4cd20fd2bdb64f5e87475df7bb09b952", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4cd20fd2bdb64f5e87475df7bb09b952.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4cd20fd2bdb64f5e87475df7bb09b952"}}, "title": "COVID-19 vaccine acceptance and hesitancy in low- and middle-income countries.", "authors": [{"family": "Sol\u00eds Arce", "given": "Julio S", "initials": "JS", "orcid": "0000-0002-0759-4142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a550afd02b5045898e009f00555d5de1.json"}}, {"family": "Warren", "given": "Shana S", "initials": "SS", "orcid": "0000-0002-2096-1402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9fc163cf8da54bbc85ee05b5fdc233f5.json"}}, {"family": "Meriggi", "given": "Niccol\u00f2 F", "initials": "NF", "orcid": "0000-0002-6757-1284", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04af70c72e0142439785ce0468521588.json"}}, {"family": "Scacco", "given": "Alexandra", "initials": "A", "orcid": "0000-0002-7282-2762", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74d1a467dea7477dabe24a2e178e0efb.json"}}, {"family": "McMurry", "given": "Nina", "initials": "N", "orcid": "0000-0003-3974-3170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2165ef7ad1d476faf3c6ef8b99019c3.json"}}, {"family": "Voors", "given": "Maarten", "initials": "M"}, {"family": "Syunyaev", "given": "Georgiy", "initials": "G"}, {"family": "Malik", "given": "Amyn Abdul", "initials": "AA", "orcid": "0000-0003-4875-9916", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be5d083c5e424b3cb0a828fc7f0e7e9a.json"}}, {"family": "Aboutajdine", "given": "Samya", "initials": "S"}, {"family": "Adeojo", "given": "Opeyemi", "initials": "O"}, {"family": "Anigo", "given": "Deborah", "initials": "D"}, {"family": "Armand", "given": "Alex", "initials": "A", "orcid": "0000-0003-1326-7348", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4e3e32500464ea2b4579d9755efb01d.json"}}, {"family": "Asad", "given": "Saher", "initials": "S"}, {"family": "Atyera", "given": "Martin", "initials": "M"}, {"family": "Augsburg", "given": "Britta", "initials": "B"}, {"family": "Awasthi", "given": "Manisha", "initials": "M"}, {"family": "Ayesiga", "given": "Gloria Eden", "initials": "GE"}, {"family": "Bancalari", "given": "Antonella", "initials": "A"}, {"family": "Bj\u00f6rkman Nyqvist", "given": "Martina", "initials": "M"}, {"family": "Borisova", "given": "Ekaterina", "initials": "E"}, {"family": "Bosancianu", "given": "Constantin Manuel", "initials": "CM", "orcid": "0000-0001-7950-9798", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/97f42ea2eb8a4b019c851b2a3928b10e.json"}}, {"family": "Cabra Garc\u00eda", "given": "Magarita Rosa", "initials": "MR"}, {"family": "Cheema", "given": "Ali", "initials": "A"}, {"family": "Collins", "given": "Elliott", "initials": "E"}, {"family": "Cuccaro", "given": "Filippo", "initials": "F"}, {"family": "Farooqi", "given": "Ahsan Zia", "initials": "AZ"}, {"family": "Fatima", "given": "Tatheer", "initials": "T"}, {"family": "Fracchia", "given": "Mattia", "initials": "M"}, {"family": "Galindo Soria", "given": "Mery Len", "initials": "ML"}, {"family": "Guariso", "given": "Andrea", "initials": "A", "orcid": "0000-0003-2128-7322", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0d94919ffa548bc8b77f2b454af38b9.json"}}, {"family": "Hasanain", "given": "Ali", "initials": "A"}, {"family": "Jaramillo", "given": "Sof\u00eda", "initials": "S"}, {"family": "Kallon", "given": "Sellu", "initials": "S"}, {"family": "Kamwesigye", "given": "Anthony", "initials": "A"}, {"family": "Kharel", "given": "Arjun", "initials": "A"}, {"family": "Kreps", "given": "Sarah", "initials": "S"}, {"family": "Levine", "given": "Madison", "initials": "M"}, {"family": "Littman", "given": "Rebecca", "initials": "R"}, {"family": "Malik", "given": "Mohammad", "initials": "M"}, {"family": "Manirabaruta", "given": "Gisele", "initials": "G"}, {"family": "Mfura", "given": "Jean L\u00e9odomir Habarimana", "initials": "JLH"}, {"family": "Momoh", "given": "Fatoma", "initials": "F"}, {"family": "Mucauque", "given": "Alberto", "initials": "A"}, {"family": "Mussa", "given": "Imamo", "initials": "I"}, {"family": "Nsabimana", "given": "Jean Aime", "initials": "JA"}, {"family": "Obara", "given": "Isaac", "initials": "I"}, {"family": "Ot\u00e1lora", "given": "Mar\u00eda Juliana", "initials": "MJ"}, {"family": "Ou\u00e9draogo", "given": "B\u00e9chir Wendemi", "initials": "BW"}, {"family": "Pare", "given": "Touba Bakary", "initials": "TB"}, {"family": "Platas", "given": "Melina R", "initials": "MR"}, {"family": "Polanco", "given": "Laura", "initials": "L"}, {"family": "Qureshi", "given": "Javaeria Ashraf", "initials": "JA"}, {"family": "Raheem", "given": "Mariam", "initials": "M"}, {"family": "Ramakrishna", "given": "Vasudha", "initials": "V"}, {"family": "Rendr\u00e1", "given": "Ismail", "initials": "I"}, {"family": "Shah", "given": "Taimur", "initials": "T"}, {"family": "Shaked", "given": "Sarene Eyla", "initials": "SE"}, {"family": "Shapiro", "given": "Jacob N", "initials": "JN", "orcid": "0000-0002-7484-229X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac5199c2900d43528cd55e05477568f7.json"}}, {"family": "Svensson", "given": "Jakob", "initials": "J"}, {"family": "Tariq", "given": "Ahsan", "initials": "A"}, {"family": "Tchibozo", "given": "Achille Mignondo", "initials": "AM"}, {"family": "Tiwana", "given": "Hamid Ali", "initials": "HA"}, {"family": "Trivedi", "given": "Bhartendu", "initials": "B"}, {"family": "Vernot", "given": "Corey", "initials": "C"}, {"family": "Vicente", "given": "Pedro C", "initials": "PC"}, {"family": "Weissinger", "given": "Laurin B", "initials": "LB"}, {"family": "Zafar", "given": "Basit", "initials": "B"}, {"family": "Zhang", "given": "Baobao", "initials": "B", "orcid": "0000-0001-7217-5035", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/929146a8be5e42f3bfffcfafc832897f.json"}}, {"family": "Karlan", "given": "Dean", "initials": "D"}, {"family": "Callen", "given": "Michael", "initials": "M"}, {"family": "Teachout", "given": "Matthieu", "initials": "M"}, {"family": "Humphreys", "given": "Macartan", "initials": "M", "orcid": "0000-0001-7029-2326", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb6b3ca6ea5c4a1cbfdf7d267a54681f.json"}}, {"family": "Mobarak", "given": "Ahmed Mushfiq", "initials": "AM", "orcid": "0000-0002-1916-3438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e85f61d8aa4409b9ffda626a51992c3.json"}}, {"family": "Omer", "given": "Saad B", "initials": "SB", "orcid": "0000-0002-5383-3474", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e884245e39b4a56945252223e3ca7d1.json"}}], "type": "journal article", "published": "2021-07-16", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956", "volume": null, "issue": null, "pages": null}, "abstract": "Widespread acceptance of COVID-19 vaccines is crucial for achieving sufficient immunization coverage to end the global pandemic, yet few studies have investigated COVID-19 vaccination attitudes in lower-income countries, where large-scale vaccination is just beginning. We analyze COVID-19 vaccine acceptance across 15 survey samples covering 10 low- and middle-income countries (LMICs) in Asia, Africa and South America, Russia (an upper-middle-income country) and the United States, including a total of 44,260 individuals. We find considerably higher willingness to take a COVID-19 vaccine in our LMIC samples (mean 80.3%; median 78%; range 30.1 percentage points) compared with the United States (mean 64.6%) and Russia (mean 30.4%). Vaccine acceptance in LMICs is primarily explained by an interest in personal protection against COVID-19, while concern about side effects is the most common reason for hesitancy. Health workers are the most trusted sources of guidance about COVID-19 vaccines. Evidence from this sample of LMICs suggests that prioritizing vaccine distribution to the Global South should yield high returns in advancing global immunization coverage. Vaccination campaigns should focus on translating the high levels of stated acceptance into actual uptake. Messages highlighting vaccine efficacy and safety, delivered by healthcare workers, could be effective for addressing any remaining hesitancy in the analyzed LMICs.", "doi": "10.1038/s41591-021-01454-y", "pmid": "34272499", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-021-01454-y"}, {"db": "URL", "key": "https://github.com/wzb-ipi/covid_vaccines_nmed", "description": "Individual participant data (de-identified), analytic code and replication file"}], "notes": [], "created": "2021-08-06T07:15:21.576Z", "modified": "2021-11-18T09:32:07.573Z"}, {"entity": "publication", "iuid": "6a7b600ff4f5428ab46a9fbca3f25d5f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a7b600ff4f5428ab46a9fbca3f25d5f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a7b600ff4f5428ab46a9fbca3f25d5f"}}, "title": "Swedish Primary Care Physicians' Intentions to Use Telemedicine: A Survey Using a New Questionnaire - Physician Attitudes and Intentions to Use Telemedicine (PAIT).", "authors": [{"family": "Pikkemaat", "given": "Miriam", "initials": "M", "orcid": "0000-0002-9808-207X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb63140be25f4d13a430425313f1b209.json"}}, {"family": "Thulesius", "given": "Hans", "initials": "H", "orcid": "0000-0002-3785-5630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f7d45ab8dd94b89873fb2e44a0a8770.json"}}, {"family": "Milos Nymberg", "given": "Veronica", "initials": "V", "orcid": "0000-0002-3836-3048", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6b591c9689b44c7c884187d0827e84a4.json"}}], "type": "journal article", "published": "2021-07-15", "journal": {"title": "Int J Gen Med", "issn": "1178-7074", "volume": "14", "pages": "3445-3455", "issn-l": null}, "abstract": "Research on intentions to use telemedicine in primary care is sparse. This survey study explored primary care physicians' intentions to use telemedicine by using a newly developed questionnaire: Physician Attitudes and Intentions to use Telemedicine.\n\nAn anonymous web-survey with questions focusing on theory-based predictors of behavioral intentions such as Attitudes, Subjective norms and Perceived behavioral control was designed, validated, and sent to all primary care physicians at 160 primary health care centers in southern Sweden from May to August 2019. The questionnaire had 29 subject items (including 49 multiple-choice sub-items). Main outcome measures were intentions to use three domains of telemedicine and correlation between theory-based predictors and behavioral intentions for using telemedicine.\n\nThe survey was validated by an expert group, amended, and then tested and retested. A majority of the 198 physicians who returned the web-surveys reported that they did not use e-mails (68%), nor video consultations (78%), chat (81%), or text messages (86%) in their everyday patient work. Yet, most physicians described a positive intention to use telemedicine in patient care for all three studied domains with Attitudes and Perceived behavioral control being significant predictors (p<0.01) for Intentions to use digital contacts (R2 = 0.54), chronic disease monitoring with digital tools (R2 = 0.47) and artificial intelligence (R2 = 0.54). A structural validation of a preliminary instrument - Physician Attitudes and Intention to use Telemedicine (PAIT) - containing 28 sub-items was done by exploratory factor analysis with acceptable explanatory, reliability and sampling adequacy measures. Five factors emerged with Eigenvalues between 1.6 and 11.1 explaining 72% of the variance. Total Cronbach's alpha was 0.91 and Kaiser-Meyer-Olkirk 0.79.\n\nBefore the covid-19 pandemic, Swedish primary care physicians reported a low use yet high behavioral intention to use telemedicine in a study where we developed the preliminary instrument Physician Attitudes and Intention to use Telemedicine. Perceived behavioral control had the largest predictive value of behavioral intention to use telemedicine. Thus, interventions aiming to increase the use of digital tools in primary care should possibly focus on empowering physicians' self-efficacy towards using them.", "doi": "10.2147/IJGM.S319497", "pmid": "34295177", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "319497"}, {"db": "pmc", "key": "PMC8290350"}], "notes": [], "created": "2021-08-05T11:07:17.298Z", "modified": "2021-08-05T11:07:17.397Z"}, {"entity": "publication", "iuid": "699431106f864e8b87a9e02f13caa5dc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/699431106f864e8b87a9e02f13caa5dc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/699431106f864e8b87a9e02f13caa5dc"}}, "title": "Potential natural polymer-based nanofibres for the development of facemasks in countering viral outbreaks.", "authors": [{"family": "Shanmugam", "given": "Vigneshwaran", "initials": "V"}, {"family": "Babu", "given": "Karthik", "initials": "K"}, {"family": "Garrison", "given": "Thomas F", "initials": "TF"}, {"family": "Capezza", "given": "Antonio J", "initials": "AJ"}, {"family": "Olsson", "given": "Richard T", "initials": "RT"}, {"family": "Ramakrishna", "given": "Seeram", "initials": "S"}, {"family": "Hedenqvist", "given": "Mikael S", "initials": "MS"}, {"family": "Singha", "given": "Shuvra", "initials": "S"}, {"family": "Bartoli", "given": "Mattia", "initials": "M"}, {"family": "Giorcelli", "given": "Mauro", "initials": "M"}, {"family": "Sas", "given": "Gabriel", "initials": "G"}, {"family": "F\u00f6rsth", "given": "Michael", "initials": "M"}, {"family": "Das", "given": "Oisik", "initials": "O", "orcid": "0000-0002-5474-1512", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8b8e5009c55423ba971d148bbe6e7f3.json"}}, {"family": "Rest\u00e1s", "given": "\u00c1goston", "initials": "\u00c1"}, {"family": "Berto", "given": "Filippo", "initials": "F"}], "type": "journal article", "published": "2021-07-15", "journal": {"title": "J Appl Polym Sci", "issn": "0021-8995", "volume": "138", "issue": "27", "pages": "50658", "issn-l": null}, "abstract": "The global coronavirus disease 2019 (COVID-19) pandemic has rapidly increased the demand for facemasks as a measure to reduce the rapid spread of the pathogen. Throughout the pandemic, some countries such as Italy had a monthly demand of ca. 90 million facemasks. Domestic mask manufacturers are capable of manufacturing 8 million masks each week, although the demand was 40 million per week during March 2020. This dramatic increase has contributed to a spike in the generation of facemask waste. Facemasks are often manufactured with synthetic materials that are non-biodegradable, and their increased usage and improper disposal are raising environmental concerns. Consequently, there is a strong interest for developing biodegradable facemasks made with for example, renewable nanofibres. A range of natural polymer-based nanofibres has been studied for their potential to be used in air filter applications. This review article examines potential natural polymer-based nanofibres along with their filtration and antimicrobial capabilities for developing biodegradable facemask that will promote a cleaner production.", "doi": "10.1002/app.50658", "pmid": "34149062", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "APP50658"}, {"db": "pmc", "key": "PMC8206777"}], "notes": [], "created": "2021-06-28T18:25:24.367Z", "modified": "2021-06-28T18:25:41.850Z"}, {"entity": "publication", "iuid": "0b057b65dd734658b81f1de2a041377d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b057b65dd734658b81f1de2a041377d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b057b65dd734658b81f1de2a041377d"}}, "title": "Characteristics and outcomes of 627 044 COVID-19 patients living with and without obesity in the United States, Spain, and the United Kingdom.", "authors": [{"family": "Recalde", "given": "Martina", "initials": "M"}, {"family": "Roel", "given": "Elena", "initials": "E", "orcid": "0000-0002-1964-3546", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad1d9cc65d3242339540f938eeceafe1.json"}}, {"family": "Pistillo", "given": "Andrea", "initials": "A", "orcid": "0000-0002-4467-0220", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/055156368b8845a0bfdc522a53cc1b0d.json"}}, {"family": "Sena", "given": "Anthony G", "initials": "AG", "orcid": "0000-0001-8630-5347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9202e069d9c24646b006b6abb640b541.json"}}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A", "orcid": "0000-0003-1202-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47f086bb6ccd49a2a5f11a32c06277c8.json"}}, {"family": "Ahmed", "given": "Waheed-Ul-Rahman", "initials": "W"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM", "orcid": "0000-0002-5630-2468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5162aab03bc04dafa809108461f18667.json"}}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Areia", "given": "Carlos", "initials": "C", "orcid": "0000-0002-4668-7069", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7232f54be5df43f0b984d0117d88a054.json"}}, {"family": "Burn", "given": "Edward", "initials": "E"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "Dawoud", "given": "Dalia", "initials": "D"}, {"family": "DuVall", "given": "Scott L", "initials": "SL"}, {"family": "Falconer", "given": "Thomas", "initials": "T"}, {"family": "Fern\u00e1ndez-Bertol\u00edn", "given": "Sergio", "initials": "S"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Gong", "given": "Mengchun", "initials": "M"}, {"family": "Lai", "given": "Lana Yin Hui", "initials": "LYH"}, {"family": "Lane", "given": "Jennifer C E", "initials": "JCE"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Mehta", "given": "Paras P", "initials": "PP"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Natarjan", "given": "Karthik", "initials": "K"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Reich", "given": "Christian G", "initials": "CG"}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR"}, {"family": "Schilling", "given": "Lisa M", "initials": "LM"}, {"family": "Shah", "given": "Karishma", "initials": "K"}, {"family": "Shah", "given": "Nigam H", "initials": "NH"}, {"family": "Subbian", "given": "Vignesh", "initials": "V"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhu", "given": "Hong", "initials": "H"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}], "type": "journal article", "published": "2021-07-15", "journal": {"title": "Int J Obes (Lond)", "issn": "1476-5497", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "A detailed characterization of patients with COVID-19 living with obesity has not yet been undertaken. We aimed to describe and compare the demographics, medical conditions, and outcomes of COVID-19 patients living with obesity (PLWO) to those of patients living without obesity.\r\n\r\nWe conducted a cohort study based on outpatient/inpatient care and claims data from January to June 2020 from Spain, the UK, and the US. We used six databases standardized to the OMOP common data model. We defined two non-mutually exclusive cohorts of patients diagnosed and/or hospitalized with COVID-19; patients were followed from index date to 30 days or death. We report the frequency of demographics, prior medical conditions, and 30-days outcomes (hospitalization, events, and death) by obesity status.\r\n\r\nWe included 627 044 (Spain: 122 058, UK: 2336, and US: 502 650) diagnosed and 160 013 (Spain: 18 197, US: 141 816) hospitalized patients with COVID-19. The prevalence of obesity was higher among patients hospitalized (39.9%, 95%CI: 39.8-40.0) than among those diagnosed with COVID-19 (33.1%; 95%CI: 33.0-33.2). In both cohorts, PLWO were more often female. Hospitalized PLWO were younger than patients without obesity. Overall, COVID-19 PLWO were more likely to have prior medical conditions, present with cardiovascular and respiratory events during hospitalization, or require intensive services compared to COVID-19 patients without obesity.\r\n\r\nWe show that PLWO differ from patients without obesity in a wide range of medical conditions and present with more severe forms of COVID-19, with higher hospitalization rates and intensive services requirements. These findings can help guiding preventive strategies of COVID-19 infection and complications and generating hypotheses for causal inference studies.", "doi": "10.1038/s41366-021-00893-4", "pmid": "34267326", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41366-021-00893-4"}, {"db": "pmc", "key": "PMC8281807"}, {"db": "URL", "key": "https://github.com/ohdsi-studies/Covid19CharacterizationCharybdis", "description": "Analytic code"}], "notes": [], "created": "2021-08-06T07:17:27.168Z", "modified": "2021-11-18T09:18:58.826Z"}, {"entity": "publication", "iuid": "4ddc361323c5468eab930e96219f795c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ddc361323c5468eab930e96219f795c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ddc361323c5468eab930e96219f795c"}}, "title": "The Impact of Stress on Health in Childhood and Adolescence in the Era of the COVID-19 Pandemic.", "authors": [{"family": "Cianfarani", "given": "Stefano", "initials": "S"}, {"family": "Pampanini", "given": "Valentina", "initials": "V"}], "type": "journal article", "published": "2021-07-14", "journal": {"title": "Horm Res Paediatr", "issn": "1663-2826", "pages": "1-5", "issn-l": "1663-2818"}, "abstract": "The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is posing many challenges to global health. Efforts from the whole scientific community have shed light on the pathogenetic mechanisms and the clinical features of SARS-CoV-2 infection as well as on potential therapeutic strategies.\n\nThe consequences of stress related to social isolation and anxiety generated by the pandemic on mental and physical health are collateral effects that are yet poorly investigated.", "doi": "10.1159/000517460", "pmid": "34261075", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "000517460"}], "notes": [], "created": "2021-08-06T07:19:08.206Z", "modified": "2021-08-06T07:19:45.627Z"}, {"entity": "publication", "iuid": "e94c3a552cb04f328a59e337030ffa31", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e94c3a552cb04f328a59e337030ffa31.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e94c3a552cb04f328a59e337030ffa31"}}, "title": "Host-Pathogen Adhesion as the Basis of Innovative Diagnostics for Emerging Pathogens.", "authors": [{"family": "van Belkum", "given": "Alex", "initials": "A", "orcid": "0000-0001-8545-5108", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d38c5ad8612e40d89df78b7e4fbd1ce3.json"}}, {"family": "Almeida", "given": "Carina", "initials": "C"}, {"family": "Bardiaux", "given": "Benjamin", "initials": "B", "orcid": "0000-0003-4014-9195", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef17bbca06e94bb4afdda56f85ac801c.json"}}, {"family": "Barrass", "given": "Sarah V", "initials": "SV"}, {"family": "Butcher", "given": "Sarah J", "initials": "SJ"}, {"family": "\u00c7aykara", "given": "Tu\u011f\u00e7e", "initials": "T"}, {"family": "Chowdhury", "given": "Sounak", "initials": "S"}, {"family": "Datar", "given": "Rucha", "initials": "R"}, {"family": "Eastwood", "given": "Ian", "initials": "I"}, {"family": "Goldman", "given": "Adrian", "initials": "A"}, {"family": "Goyal", "given": "Manisha", "initials": "M"}, {"family": "Happonen", "given": "Lotta", "initials": "L"}, {"family": "Izadi-Pruneyre", "given": "Nadia", "initials": "N"}, {"family": "Jacobsen", "given": "Theis", "initials": "T"}, {"family": "Johnson", "given": "Pirjo H", "initials": "PH"}, {"family": "Kempf", "given": "Volkhard A J", "initials": "VAJ"}, {"family": "Kiessling", "given": "Andreas", "initials": "A"}, {"family": "Bueno", "given": "Juan Leva", "initials": "JL"}, {"family": "Malik", "given": "Anchal", "initials": "A"}, {"family": "Malmstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0002-2889-7169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e42dacb3a60b456dbbfb3e0a0c51a606.json"}}, {"family": "Meuskens", "given": "Ina", "initials": "I"}, {"family": "Milner", "given": "Paul A", "initials": "PA"}, {"family": "Nilges", "given": "Michael", "initials": "M"}, {"family": "Pamme", "given": "Nicole", "initials": "N", "orcid": "0000-0002-9391-9387", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1000b4c42944339b4f3eedf7a7deb8b.json"}}, {"family": "Peyman", "given": "Sally A", "initials": "SA", "orcid": "0000-0002-1600-5100", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f53dab03308c44ca98d7af152064b37e.json"}}, {"family": "Rodrigues", "given": "Ligia R", "initials": "LR", "orcid": "0000-0001-9265-0630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dcb8d38170cd4c3a80047faf3771246c.json"}}, {"family": "Rodriguez-Mateos", "given": "Pablo", "initials": "P"}, {"family": "Sande", "given": "Maria G", "initials": "MG"}, {"family": "Silva", "given": "Carla Joana", "initials": "CJ"}, {"family": "Stasiak", "given": "Aleksandra Cecylia", "initials": "AC", "orcid": "0000-0001-6914-5740", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d91d81aaa6b4328b45f43a294276ae0.json"}}, {"family": "Stehle", "given": "Thilo", "initials": "T"}, {"family": "Thibau", "given": "Arno", "initials": "A"}, {"family": "Vaca", "given": "Diana J", "initials": "DJ"}, {"family": "Linke", "given": "Dirk", "initials": "D"}], "type": "journal article", "published": "2021-07-14", "journal": {"title": "Diagnostics (Basel)", "issn": "2075-4418", "volume": "11", "issue": "7", "issn-l": null}, "abstract": "Infectious diseases are an existential health threat, potentiated by emerging and re-emerging viruses and increasing bacterial antibiotic resistance. Targeted treatment of infectious diseases requires precision diagnostics, especially in cases where broad-range therapeutics such as antibiotics fail. There is thus an increasing need for new approaches to develop sensitive and specific in vitro diagnostic (IVD) tests. Basic science and translational research are needed to identify key microbial molecules as diagnostic targets, to identify relevant host counterparts, and to use this knowledge in developing or improving IVD. In this regard, an overlooked feature is the capacity of pathogens to adhere specifically to host cells and tissues. The molecular entities relevant for pathogen-surface interaction are the so-called adhesins. Adhesins vary from protein compounds to (poly-)saccharides or lipid structures that interact with eukaryotic host cell matrix molecules and receptors. Such interactions co-define the specificity and sensitivity of a diagnostic test. Currently, adhesin-receptor binding is typically used in the pre-analytical phase of IVD tests, focusing on pathogen enrichment. Further exploration of adhesin-ligand interaction, supported by present high-throughput \"omics\" technologies, might stimulate a new generation of broadly applicable pathogen detection and characterization tools. This review describes recent results of novel structure-defining technologies allowing for detailed molecular analysis of adhesins, their receptors and complexes. Since the host ligands evolve slowly, the corresponding adhesin interaction is under selective pressure to maintain a constant receptor binding domain. IVD should exploit such conserved binding sites and, in particular, use the human ligand to enrich the pathogen. We provide an inventory of methods based on adhesion factors and pathogen attachment mechanisms, which can also be of relevance to currently emerging pathogens, including SARS-CoV-2, the causative agent of COVID-19.", "doi": "10.3390/diagnostics11071259", "pmid": "34359341", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "diagnostics11071259"}, {"db": "pmc", "key": "PMC8305138"}], "notes": [], "created": "2021-08-11T14:37:57.779Z", "modified": "2021-08-11T14:37:57.951Z"}, {"entity": "publication", "iuid": "78b963daa11f420b89353538b366bd7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/78b963daa11f420b89353538b366bd7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/78b963daa11f420b89353538b366bd7e"}}, "title": "Fear and anxiety in the face of COVID-19: Negative dispositions towards risk and uncertainty as vulnerability factors.", "authors": [{"family": "Millroth", "given": "Philip", "initials": "P"}, {"family": "Frey", "given": "Renato", "initials": "R"}], "type": "journal article", "published": "2021-07-14", "journal": {"title": "J Anxiety Disord", "issn": "1873-7897", "issn-l": null, "volume": "83", "issue": null, "pages": "102454"}, "abstract": "In the face of the COVID-19 pandemic it is important to identify factors that make people particularly vulnerable of developing mental-health issues in order to provide case-specific treatments. In this article, we examine the roles of two psychological constructs - originally put forth in the behavioral decision sciences - in predicting interindividual differences in fear responses: general risk aversion (GRA) and intolerance of uncertainty (IU). We first provide a review of these constructs and illustrate why they may play important roles in shaping anxiety-related disorders. Thereafter we present an empirical study that collected survey data from 550 U.S. residents, comprising self-assessments of dispositions towards risk and uncertainty, anxiety- and depression levels, as well as demographic variables - to thus test the extent to which these psychological constructs are predictive of strong fear responses related to COVID-19 (i.e., mortal fear, racing heart). The results from Bayesian multi-model inference analyses showed that GRA and IU were more powerful predictors of fear responses than demographic variables. Moreover, the predictive power of these constructs was independent of general anxiety- and depression levels. Subsequent mediation analyses showed that the effects of GRA and IU were both direct and indirect via anxiety. We conclude by discussing possible treatment options, but also highlight that future research needs to further examine causal pathways and conceptual overlaps.", "doi": "10.1016/j.janxdis.2021.102454", "pmid": "34298237", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0887-6185(21)00101-8"}, {"db": "URL", "key": "https://osf.io/xb4ce/", "description": "Survey data"}], "notes": [], "created": "2021-08-05T07:07:49.825Z", "modified": "2021-11-18T09:14:45.531Z"}, {"entity": "publication", "iuid": "121e72cbf43f4f2fa38c2a5fb1a12997", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/121e72cbf43f4f2fa38c2a5fb1a12997.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/121e72cbf43f4f2fa38c2a5fb1a12997"}}, "title": "An international study on psychological coping during COVID-19: Towards a meaning-centered coping style.", "authors": [{"family": "Eisenbeck", "given": "Nikolett", "initials": "N"}, {"family": "Carreno", "given": "David F", "initials": "DF"}, {"family": "Wong", "given": "Paul T P", "initials": "PTP"}, {"family": "Hicks", "given": "Joshua A", "initials": "JA"}, {"family": "Mar\u00eda", "given": "Ru\u00edz-Ruano Garc\u00eda", "initials": "RG"}, {"family": "Puga", "given": "Jorge L", "initials": "JL"}, {"family": "Greville", "given": "James", "initials": "J"}, {"family": "Testoni", "given": "Ines", "initials": "I"}, {"family": "Biancalani", "given": "Gianmarco", "initials": "G"}, {"family": "L\u00f3pez", "given": "Ana Carla Cepeda", "initials": "ACC"}, {"family": "Villareal", "given": "Sof\u00eda", "initials": "S"}, {"family": "Enea", "given": "Violeta", "initials": "V"}, {"family": "Schulz-Quach", "given": "Christian", "initials": "C"}, {"family": "Jansen", "given": "Jonas", "initials": "J"}, {"family": "Sanchez-Ruiz", "given": "Maria-Jose", "initials": "M"}, {"family": "Y\u0131ld\u0131r\u0131m", "given": "Murat", "initials": "M"}, {"family": "Arslan", "given": "G\u00f6kmen", "initials": "G"}, {"family": "Cruz", "given": "Jos\u00e9 Fernando A", "initials": "JFA"}, {"family": "Sofia", "given": "Rui Manuel", "initials": "RM"}, {"family": "Ferreira", "given": "Maria Jos\u00e9", "initials": "MJ"}, {"family": "Ashraf", "given": "Farzana", "initials": "F"}, {"family": "W\u0105sowicz", "given": "Gra\u017cyna", "initials": "G"}, {"family": "Shalaby", "given": "Shahinaz M", "initials": "SM"}, {"family": "Amer", "given": "Reham A", "initials": "RA"}, {"family": "Yousfi", "given": "Hadda", "initials": "H"}, {"family": "Chukwuorji", "given": "JohnBosco Chika", "initials": "JC"}, {"family": "Guerra", "given": "Valeschka M", "initials": "VM"}, {"family": "Singh", "given": "Sandeep", "initials": "S"}, {"family": "Heintzelman", "given": "Samantha", "initials": "S"}, {"family": "Hutapea", "given": "Bonar", "initials": "B"}, {"family": "B\u00e9jaoui", "given": "Bouchara", "initials": "B"}, {"family": "Dash", "given": "Arobindu", "initials": "A"}, {"family": "Schlosser", "given": "Karoly Kornel", "initials": "KK"}, {"family": "Anniko", "given": "Malin K", "initials": "MK"}, {"family": "Rossa", "given": "Martin", "initials": "M"}, {"family": "Wongcharee", "given": "Hattaphan", "initials": "H"}, {"family": "Avsec", "given": "Andreja", "initials": "A"}, {"family": "Kocjan", "given": "Gaja Zager", "initials": "GZ"}, {"family": "Kav\u010di\u010d", "given": "Tina", "initials": "T"}, {"family": "Leontiev", "given": "Dmitry A", "initials": "DA"}, {"family": "Taranenko", "given": "Olga", "initials": "O"}, {"family": "Rasskazova", "given": "Elena", "initials": "E"}, {"family": "Maher", "given": "Elizabeth", "initials": "E"}, {"family": "Garc\u00eda-Montes", "given": "Jos\u00e9 Manuel", "initials": "JM"}], "type": "journal article", "published": "2021-07-14", "journal": {"title": "Int J Clin Health Psychol", "issn": "2174-0852", "issn-l": null, "volume": "22", "issue": "1", "pages": "100256"}, "abstract": "This study examined the role of different psychological coping mechanisms in mental and physical health during the initial phases of the COVID-19 crisis with an emphasis on meaning-centered coping.\r\n\r\nA total of 11,227 people from 30 countries across all continents participated in the study and completed measures of psychological distress (depression, stress, and anxiety), loneliness, well-being, and physical health, together with measures of problem-focused and emotion-focused coping, and a measure called the Meaning-centered Coping Scale (MCCS) that was developed in the present study. Validation analyses of the MCCS were performed in all countries, and data were assessed by multilevel modeling (MLM).\r\n\r\nThe MCCS showed a robust one-factor structure in 30 countries with good test-retest, concurrent and divergent validity results. MLM analyses showed mixed results regarding emotion and problem-focused coping strategies. However, the MCCS was the strongest positive predictor of physical and mental health among all coping strategies, independently of demographic characteristics and country-level variables.\r\n\r\nThe findings suggest that the MCCS is a valid measure to assess meaning-centered coping. The results also call for policies promoting effective coping to mitigate collective suffering during the pandemic.", "doi": "10.1016/j.ijchp.2021.100256", "pmid": "34429729", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1697-2600(21)00037-5"}, {"db": "pmc", "key": "PMC8355913"}], "notes": [], "created": "2021-08-27T09:36:53.616Z", "modified": "2021-11-18T09:03:19.676Z"}, {"entity": "publication", "iuid": "3dee1961748f40819892bf7be86fbd4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3dee1961748f40819892bf7be86fbd4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3dee1961748f40819892bf7be86fbd4d"}}, "title": "A pre/post analysis of the impact of the COVID-19 pandemic on the psychosocial work environment and recovery among healthcare workers in a large university hospital in Sweden.", "authors": [{"family": "Jonsdottir", "given": "Ingibj\u00f6rg H", "initials": "IH"}, {"family": "Degl'Innocenti", "given": "Alessio", "initials": "A"}, {"family": "Ahlstrom", "given": "Linda", "initials": "L"}, {"family": "Finizia", "given": "Caterina", "initials": "C"}, {"family": "Wijk", "given": "Helle", "initials": "H"}, {"family": "\u00c5kerstr\u00f6m", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-07-14", "journal": {"title": "J Public Health Res", "issn": "2279-9028", "issn-l": null}, "abstract": "The impact of the COVID-19 pandemic on workload, mental health, and well-being of healthcare workers, and particularly those on the front-line, has received considerable attention.\n\nWe surveyed hospital employees about their working environment during the pandemic and identified departments which were negatively affected in comparison to the pre-pandemic situation, as well as factors contributing to this. Setting and participants We surveyed all hospital employees at Sahlgrenska University Hospital, Sweden in September 2020 and compared results across departments and to the results of a large employee survey from October 2019.\n\nThe overall impact of the pandemic on perceived working conditions and possibility for recovery differed among departments. During the pandemic, healthcare workers working with COVID-19 patients reported poorer working environments than other employees. Factors significantly related to perception of work environment and recovery during the pandemic included worries of being infected, departmental transfer, and having insufficient access to personal protective equipment. Men reported better working conditions than women in all, but one item and higher age was related to better perceived working environment.\n\nOur results indicate that the pandemic differentially affects hospital departments and underscores the multifactorial nature of this topic. Contributing factors to poor perceived working environment could be addressed at times of high workload, such as during the pandemic, including providing appropriate support to managers, ensuring possibility for recovery during working hours, and acknowledging worries about infection. Young healthcare workers and staff who are relocated due to the pandemic warrant special attention.", "doi": "10.4081/jphr.2021.2329", "pmid": "34278769", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-05T11:12:31.477Z", "modified": "2021-08-05T11:12:31.489Z"}, {"entity": "publication", "iuid": "440e484854514d65875c54e966788b05", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/440e484854514d65875c54e966788b05.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/440e484854514d65875c54e966788b05"}}, "title": "Variant Analysis of SARS-CoV-2 Genomes from Belgian Military Personnel Engaged in Overseas Missions and Operations.", "authors": [{"family": "Pirnay", "given": "Jean-Paul", "initials": "JP", "orcid": "0000-0002-6863-5219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/57c49628604342ffae1231718cf6529e.json"}}, {"family": "Selhorst", "given": "Philippe", "initials": "P", "orcid": "0000-0002-4488-5790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a15ee083f17430aa249b4751f0b2002.json"}}, {"family": "Hong", "given": "Samuel L", "initials": "SL", "orcid": "0000-0001-6354-4943", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90a9fb0495604bb891f4fc786eca0a98.json"}}, {"family": "Cochez", "given": "Christel", "initials": "C"}, {"family": "Potter", "given": "Barney", "initials": "B"}, {"family": "Maes", "given": "Piet", "initials": "P"}, {"family": "Petrillo", "given": "Mauro", "initials": "M", "orcid": "0000-0002-6782-4704", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8183c35e5c7b40d1a7ea56a85521451b.json"}}, {"family": "Dudas", "given": "Gytis", "initials": "G", "orcid": "0000-0002-0227-4158", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/941f89c075f744219ea42f21be699871.json"}}, {"family": "Claes", "given": "Vincent", "initials": "V", "orcid": "0000-0001-6398-4009", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd75ac5e4f564a4f9feb651f1ecf4150.json"}}, {"family": "Van der Beken", "given": "Yolien", "initials": "Y"}, {"family": "Verbeken", "given": "Gilbert", "initials": "G"}, {"family": "Degueldre", "given": "Julie", "initials": "J"}, {"family": "Dellicour", "given": "Simon", "initials": "S", "orcid": "0000-0001-9558-1052", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35378313b42d4026a1deace84240c300.json"}}, {"family": "Cuypers", "given": "Lize", "initials": "L", "orcid": "0000-0002-9433-8752", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5fde6d7af1e406a83cc6284e285b473.json"}}, {"family": "T'Sas", "given": "France", "initials": "F"}, {"family": "Van den Eede", "given": "Guy", "initials": "G"}, {"family": "Verhasselt", "given": "Bruno", "initials": "B"}, {"family": "Weuts", "given": "Wouter", "initials": "W"}, {"family": "Smets", "given": "Cedric", "initials": "C"}, {"family": "Mertens", "given": "Jan", "initials": "J"}, {"family": "Geeraerts", "given": "Philippe", "initials": "P"}, {"family": "Ari\u00ebn", "given": "Kevin K", "initials": "KK"}, {"family": "Andr\u00e9", "given": "Emmanuel", "initials": "E"}, {"family": "Neirinckx", "given": "Pierre", "initials": "P"}, {"family": "Soentjens", "given": "Patrick", "initials": "P"}, {"family": "Baele", "given": "Guy", "initials": "G", "orcid": "0000-0002-1915-7732", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ed706bd4a744d8da6a2561880e98eba.json"}}], "type": "journal article", "published": "2021-07-13", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "7", "issn-l": "1999-4915"}, "abstract": "More than a year after the first identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as the causative agent of the 2019 coronavirus disease (COVID-19) in China, the emergence and spread of genomic variants of this virus through travel raise concerns regarding the introduction of lineages in previously unaffected regions, requiring adequate containment strategies. Concomitantly, such introductions fuel worries about a possible increase in transmissibility and disease severity, as well as a possible decrease in vaccine efficacy. Military personnel are frequently deployed on missions around the world. As part of a COVID-19 risk mitigation strategy, Belgian Armed Forces that engaged in missions and operations abroad were screened (7683 RT-qPCR tests), pre- and post-mission, for the presence of SARS-CoV-2, including the identification of viral lineages. Nine distinct viral genotypes were identified in soldiers returning from operations in Niger, the Democratic Republic of the Congo, Afghanistan, and Mali. The SARS-CoV-2 variants belonged to major clades 19B, 20A, and 20B (Nextstrain nomenclature), and included \"variant of interest\" B.1.525, \"variant under monitoring\" A.27, as well as lineages B.1.214, B.1, B.1.1.254, and A (pangolin nomenclature), some of which are internationally monitored due to the specific mutations they harbor. Through contact tracing and phylogenetic analysis, we show that isolation and testing policies implemented by the Belgian military command appear to have been successful in containing the influx and transmission of these distinct SARS-CoV-2 variants into military and civilian populations.", "doi": "10.3390/v13071359", "pmid": "34372565", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "v13071359"}], "notes": [], "created": "2021-08-11T14:32:26.858Z", "modified": "2021-08-11T14:33:04.232Z"}, {"entity": "publication", "iuid": "158d2c73662a4e4c9e3676dee6adb5e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/158d2c73662a4e4c9e3676dee6adb5e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/158d2c73662a4e4c9e3676dee6adb5e2"}}, "title": "Oxygen and Mortality in COVID-19 Pneumonia: A Comparative Analysis of Supplemental Oxygen Policies and Health Outcomes Across 26 Countries.", "authors": [{"family": "Mansab", "given": "Fatma", "initials": "F"}, {"family": "Donnelly", "given": "Harry", "initials": "H"}, {"family": "Kussner", "given": "Albrecht", "initials": "A"}, {"family": "Neil", "given": "James", "initials": "J"}, {"family": "Bhatti", "given": "Sohail", "initials": "S"}, {"family": "Goyal", "given": "Daniel K", "initials": "DK"}], "type": "journal article", "published": "2021-07-13", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "580585", "issn-l": "2296-2565"}, "abstract": "Introduction: Hypoxia is the main cause of morbidity and mortality in COVID-19. During the COVID-19 pandemic, some countries have reduced access to supplemental oxygen, whereas other nations have maintained and even improved access to supplemental oxygen. We examined whether variation in the nationally determined oxygen guidelines had any association with national mortality rates in COVID-19. Methods: Three independent investigators searched for, identified, and extracted the nationally recommended target oxygen levels for the commencement of oxygen in COVID-19 pneumonia from the 29 worst affected countries. Mortality estimates were calculated from three independent sources. We then applied both parametric (Pearson's R) and non-parametric (Kendall's Tau B) tests of bivariate association to determine the relationship between case fatality rate (CFR) and target SpO2, and also between potential confounders and CFR. Results: Of the 26 nations included, 15 had employed conservative oxygen strategies to manage COVID-19 pneumonia. Of them, Belgium, France, USA, Canada, China, Germany, Mexico, Spain, Sweden, and the UK guidelines advised commencing oxygen when oxygen saturations (SpO2) fell to 91% or less. A statistically significant correlation was found between SpO2 and CFR both parametrically (R = -0.53, P < 0.01) and non-parametrically (-0.474, P < 0.01). Conclusion: Our study highlights the disparity in oxygen provision for COVID-19 patients between the nations analysed. In those nations that pursued a conservative oxygen strategy, there was an association with higher national mortality rates. We discuss the potential reasons for such an association.", "doi": "10.3389/fpubh.2021.580585", "pmid": "34327182", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8313806"}], "notes": [], "created": "2021-08-04T17:04:55.055Z", "modified": "2021-08-04T17:05:02.692Z"}, {"entity": "publication", "iuid": "61e2ebaad09a477094041f730fbe213c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61e2ebaad09a477094041f730fbe213c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61e2ebaad09a477094041f730fbe213c"}}, "title": "Indications that Stockholm has reached herd immunity, given limited restrictions, against several variants of SARS-CoV-2", "authors": [{"family": "Carlsson", "given": "Marcus", "initials": "M", "orcid": "0000-0002-3761-9072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9492f80f98584a4c949a0114fb44ef71.json"}}, {"family": "S\u00f6derberg-Naucl\u00e9r", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-8955-3610", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f10026ba9a64bfea2fc49de969cdde9.json"}}], "type": "posted-content", "published": "2021-07-13", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.07.07.21260167", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-08-03T11:47:39.010Z", "modified": "2021-08-03T11:48:02.261Z"}, {"entity": "publication", "iuid": "8b75445e0d084e4690eb0ff93f85c84b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b75445e0d084e4690eb0ff93f85c84b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b75445e0d084e4690eb0ff93f85c84b"}}, "title": "COVID-19 Vaccines and Thrombosis-Roadblock or Dead-End Street?", "authors": [{"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Barh", "given": "Debmalya", "initials": "D", "orcid": "0000-0002-2557-7768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1de09014a90148069b6627b93ac71ea8.json"}}, {"family": "Uhal", "given": "Bruce D", "initials": "BD", "orcid": "0000-0002-5201-432X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d8004448df445bb86d5c733aa143e9b.json"}}, {"family": "Takayama", "given": "Kazuo", "initials": "K", "orcid": "0000-0002-1132-2457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de9286e534764113a02e6e51be237f86.json"}}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA", "orcid": "0000-0002-9519-6338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b9ca27af4d347c9b4097d3fd0ecf0bf.json"}}, {"family": "Abd El-Aziz", "given": "Tarek Mohamed", "initials": "TM", "orcid": "0000-0002-3441-9673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3bd8ea28f1e24943b73f6d9e5d411aa3.json"}}, {"family": "Lal", "given": "Amos", "initials": "A", "orcid": "0000-0002-0021-2033", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf77b6a9233341f996b3ef515f41aa0f.json"}}, {"family": "Redwan", "given": "Elrashdy M", "initials": "EM", "orcid": "0000-0001-8246-0075", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf6f9cfd2f99436ea2eaecf2d83b07e9.json"}}, {"family": "Adadi", "given": "Parise", "initials": "P", "orcid": "0000-0003-4724-9463", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d2c862c9c1c4a1c8471708ae9628ef7.json"}}, {"family": "Chauhan", "given": "Gaurav", "initials": "G", "orcid": "0000-0002-5400-5638", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd1323f836244e91a37c69bb627cf0cd.json"}}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Azad", "given": "Gajendra Kumar", "initials": "GK", "orcid": "0000-0001-5478-526X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94c4f27a019d4cf2a9e459e6a914fa9c.json"}}, {"family": "Rezaei", "given": "Nima", "initials": "N", "orcid": "0000-0002-3836-1827", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/38c4c1dfbc464a1c8a08ab690568c6bd.json"}}, {"family": "Serrano-Aroca", "given": "\u00c1ngel", "initials": "\u00c1", "orcid": "0000-0002-9953-3848", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c8f520da33b429a8bc7eb19ff14f58d.json"}}, {"family": "Bazan", "given": "Nicolas G", "initials": "NG"}, {"family": "Hassan", "given": "Sk Sarif", "initials": "SS", "orcid": "0000-0003-4331-722X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c16068e54c442e580b4ba62905aa848.json"}}, {"family": "Panda", "given": "Pritam Kumar", "initials": "PK", "orcid": "0000-0003-4879-2302", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bbd0a928e33842a894bcb569549712c7.json"}}, {"family": "Pal Choudhury", "given": "Pabitra", "initials": "P"}, {"family": "Pizzol", "given": "Damiano", "initials": "D", "orcid": "0000-0003-4122-0774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b2b7ce8dc27462088eb836279b2d194.json"}}, {"family": "Kandimalla", "given": "Ramesh", "initials": "R", "orcid": "0000-0002-3313-4393", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5afbbf2e86e04041996b924b05b188f1.json"}}, {"family": "Baetas-da-Cruz", "given": "Wagner", "initials": "W"}, {"family": "Mishra", "given": "Yogendra Kumar", "initials": "YK", "orcid": "0000-0002-8786-9379", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4216dffbb5d04509b18c9f17fafee087.json"}}, {"family": "Palu", "given": "Giorgio", "initials": "G"}, {"family": "Brufsky", "given": "Adam M", "initials": "AM", "orcid": "0000-0001-8080-7960", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/869234cfbe6c42d5b0da85d4e9ee7464.json"}}, {"family": "Tambuwala", "given": "Murtaza M", "initials": "MM", "orcid": "0000-0001-8499-9891", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8ed708303c14ff8b1b3e9d1e60a4dfe.json"}}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN", "orcid": "0000-0002-4037-5857", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69478f3c84b7411fa4bb1c0043ce542b.json"}}], "type": "journal article", "published": "2021-07-13", "journal": {"title": "Biomolecules", "issn": "2218-273X", "volume": "11", "issue": "7", "issn-l": null}, "abstract": "Two adenovirus-based vaccines, ChAdOx1 nCoV-19 and Ad26.COV2.S, and two mRNA-based vaccines, BNT162b2 and mRNA.1273, have been approved by the European Medicines Agency (EMA), and are invaluable in preventing and reducing the incidence of coronavirus disease-2019 (COVID-19). Recent reports have pointed to thrombosis with associated thrombocytopenia as an adverse effect occurring at a low frequency in some individuals after vaccination. The causes of such events may be related to SARS-CoV-2 spike protein interactions with different C-type lectin receptors, heparan sulfate proteoglycans (HSPGs) and the CD147 receptor, or to different soluble splice variants of the spike protein, adenovirus vector interactions with the CD46 receptor or platelet factor 4 antibodies. Similar findings have been reported for several viral diseases after vaccine administration. In addition, immunological mechanisms elicited by viral vectors related to cellular delivery could play a relevant role in individuals with certain genetic backgrounds. Although rare, the potential COVID-19 vaccine-induced immune thrombotic thrombocytopenia (VITT) requires immediate validation, especially in risk groups, such as the elderly, chronic smokers, and individuals with pre-existing incidences of thrombocytopenia; and if necessary, a reformulation of existing vaccines.", "doi": "10.3390/biom11071020", "pmid": "34356644", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "biom11071020"}, {"db": "pmc", "key": "PMC8301964"}], "notes": [], "created": "2021-08-11T14:40:37.371Z", "modified": "2021-08-11T14:40:37.721Z"}, {"entity": "publication", "iuid": "36cf32d8e1f14ab3a9de2cef2a759e5f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/36cf32d8e1f14ab3a9de2cef2a759e5f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/36cf32d8e1f14ab3a9de2cef2a759e5f"}}, "title": "Blue Biotechnology: Computational Screening of Sarcophyton Cembranoid Diterpenes for SARS-CoV-2 Main Protease Inhibition.", "authors": [{"family": "Ibrahim", "given": "Mahmoud A A", "initials": "MAA", "orcid": "0000-0003-4819-2040", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/552195f5616e456b82fd45359b56f9c7.json"}}, {"family": "Abdelrahman", "given": "Alaa H M", "initials": "AHM", "orcid": "0000-0003-3527-0126", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89f2d2ac6ab343728c329fb71b4fa732.json"}}, {"family": "Atia", "given": "Mohamed A M", "initials": "MAM", "orcid": "0000-0003-2462-1269", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e973a0f11ca0459fa876c875fe3989cb.json"}}, {"family": "Mohamed", "given": "Tarik A", "initials": "TA", "orcid": "0000-0003-1639-3518", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69bfe5a2f846439dbea3d4d597546ec4.json"}}, {"family": "Moustafa", "given": "Mahmoud F", "initials": "MF"}, {"family": "Hakami", "given": "Abdulrahim R", "initials": "AR", "orcid": "0000-0003-2101-8800", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78ae225ce54745b489204cf1f3dd57c4.json"}}, {"family": "Khalifa", "given": "Shaden A M", "initials": "SAM"}, {"family": "Alhumaydhi", "given": "Fahad A", "initials": "FA", "orcid": "0000-0002-0151-8309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/575d134a229546749190bad9e2018ea1.json"}}, {"family": "Alrumaihi", "given": "Faris", "initials": "F", "orcid": "0000-0002-0850-5500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b60452d537bd43e1a01af011e03c5ea5.json"}}, {"family": "Abidi", "given": "Syed Hani", "initials": "SH", "orcid": "0000-0001-9497-0902", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/401fcf2d494a4afaafec85336c009b6b.json"}}, {"family": "Allemailem", "given": "Khaled S", "initials": "KS", "orcid": "0000-0002-6486-9835", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d53444ec5a8f4b15b4d1e455a9578733.json"}}, {"family": "Efferth", "given": "Thomas", "initials": "T"}, {"family": "Soliman", "given": "Mahmoud E", "initials": "ME"}, {"family": "Par\u00e9", "given": "Paul W", "initials": "PW", "orcid": "0000-0003-1644-723X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ac0f276b143475db0df390f50c8658b.json"}}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR", "orcid": "0000-0002-2519-6690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d35dc868deec44a69caa5ed9a65c15ce.json"}}, {"family": "Hegazy", "given": "Mohamed-Elamir F", "initials": "MF", "orcid": "0000-0002-0343-4969", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/efe074c3fdcc4601ba363cbdb84595bf.json"}}], "type": "journal article", "published": "2021-07-13", "journal": {"title": "Mar Drugs", "issn": "1660-3397", "volume": "19", "issue": "7", "issn-l": null}, "abstract": "The coronavirus pandemic has affected more than 150 million people, while over 3.25 million people have died from the coronavirus disease 2019 (COVID-19). As there are no established therapies for COVID-19 treatment, drugs that inhibit viral replication are a promising target; specifically, the main protease (Mpro) that process CoV-encoded polyproteins serves as an Achilles heel for assembly of replication-transcription machinery as well as down-stream viral replication. In the search for potential antiviral drugs that target Mpro, a series of cembranoid diterpenes from the biologically active soft-coral genus Sarcophyton have been examined as SARS-CoV-2 Mpro inhibitors. Over 360 metabolites from the genus were screened using molecular docking calculations. Promising diterpenes were further characterized by molecular dynamics (MD) simulations based on molecular mechanics-generalized Born surface area (MM-GBSA) binding energy calculations. According to in silico calculations, five cembranoid diterpenes manifested adequate binding affinities as Mpro inhibitors with \u0394Gbinding < -33.0 kcal/mol. Binding energy and structural analyses of the most potent Sarcophyton inhibitor, bislatumlide A (340), was compared to darunavir, an HIV protease inhibitor that has been recently subjected to clinical-trial as an anti-COVID-19 drug. In silico analysis indicates that 340 has a higher binding affinity against Mpro than darunavir with \u0394Gbinding values of -43.8 and -34.8 kcal/mol, respectively throughout 100 ns MD simulations. Drug-likeness calculations revealed robust bioavailability and protein-protein interactions were identified for 340; biochemical signaling genes included ACE, MAPK14 and ESR1 as identified based on a STRING database. Pathway enrichment analysis combined with reactome mining revealed that 340 has the capability to re-modulate the p38 MAPK pathway hijacked by SARS-CoV-2 and antagonize injurious effects. These findings justify further in vivo and in vitro testing of 340 as an antiviral agent against SARS-CoV-2.", "doi": "10.3390/md19070391", "pmid": "34356816", "labels": {"Category: Biochemistry": null, "Category: Drug Discovery": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "md19070391"}, {"db": "pmc", "key": "PMC8308023"}], "notes": [], "created": "2021-08-11T14:39:16.626Z", "modified": "2021-08-11T14:39:16.895Z"}, {"entity": "publication", "iuid": "bb24d0e5e1c24a38992eb445246d9f76", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb24d0e5e1c24a38992eb445246d9f76.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb24d0e5e1c24a38992eb445246d9f76"}}, "title": "Epidemiological characteristics and initial spatiotemporal visualisation of COVID-19 in a major city in the Middle East.", "authors": [{"family": "MohammadEbrahimi", "given": "Shahab", "initials": "S", "orcid": "0000-0002-1494-1544", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bdc10ef3b2e54ae18547877efaf5c000.json"}}, {"family": "Mohammadi", "given": "Alireza", "initials": "A", "orcid": "0000-0002-3327-0942", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f5101616a2d41468b9a706f743f49b3.json"}}, {"family": "Bergquist", "given": "Robert", "initials": "R", "orcid": "0000-0002-0190-1084", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78ef78e2b8334cb99d848a429434cfb5.json"}}, {"family": "Dolatkhah", "given": "Fatemeh", "initials": "F", "orcid": "0000-0002-8342-6618", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/77db8d4308024e9e86b854718b579739.json"}}, {"family": "Olia", "given": "Mahsa", "initials": "M", "orcid": "0000-0002-5013-7000", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e84399127f9b4ba48b884b3ca9e9e4dd.json"}}, {"family": "Tavakolian", "given": "Ayoub", "initials": "A", "orcid": "0000-0002-4884-8524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69886ea0ac0547e0b85f16b91b3d3f41.json"}}, {"family": "Pishgar", "given": "Elahe", "initials": "E", "orcid": "0000-0001-7217-2598", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac8cf4f85ea34ad297a6343ef7bc4044.json"}}, {"family": "Kiani", "given": "Behzad", "initials": "B", "orcid": "0000-0002-8816-328X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c30601593bd54510866e077ade6765d0.json"}}], "type": "journal article", "published": "2021-07-12", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "1373"}, "abstract": "The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) emerged initially in China in December 2019 causing the COVID-19 disease, which quickly spread worldwide. Iran was one of the first countries outside China to be affected in a major way and is now under the spell of a fourth wave. This study aims to investigate the epidemiological characteristics of COVID-19 cases in north-eastern Iran through mapping the spatiotemporal trend of the disease.\r\n\r\nThe study comprises data of 4000 patients diagnosed by laboratory assays or clinical investigation from the beginning of the disease on Feb 14, 2020, until May 11, 2020. Epidemiological features and spatiotemporal trends of the disease in the study area were explored by classical statistical approaches and Geographic Information Systems.\r\n\r\nMost common symptoms were dyspnoea (69.4%), cough (59.4%), fever (54.4%) and weakness (19.5%). Approximately 82% of those who did not survive suffered from dyspnoea. The highest Case Fatality Rate (CFR) was related to those with cardiovascular disease (27.9%) and/or diabetes (18.1%). Old age (\u226560 years) was associated with an almost five-fold increased CFR. Odds Ratio (OR) showed malignancy (3.8), nervous diseases (2.2), and respiratory diseases (2.2) to be significantly associated with increased CFR with developments, such as hospitalization at the ICU (2.9) and LOS (1.1) also having high correlations. Furthermore, spatial analyses revealed a geographical pattern in terms of both incidence and mortality rates, with COVID-19 first being observed in suburban areas from where the disease swiftly spread into downtown reaching a peak between 25 February to 06 March (4 incidences per km2). Mortality peaked 3 weeks later after which the infection gradually decreased. Out of patients investigated by the spatiotemporal approach (n = 727), 205 (28.2%) did not survive and 66.8% of them were men.\r\n\r\nOlder adults and people with severe co-morbidities were at higher risk for developing serious complications due to COVID-19. Applying spatiotemporal methods to identify the transmission trends and high-risk areas can rapidly be documented, thereby assisting policymakers in designing and implementing tailored interventions to control and prevent not only COVID-19 but also other rapidly spreading epidemics/pandemics.", "doi": "10.1186/s12889-021-11326-2", "pmid": "34247616", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11326-2"}, {"db": "pmc", "key": "PMC8272989"}], "notes": [], "created": "2021-08-06T07:49:43.922Z", "modified": "2021-11-18T08:58:58.477Z"}, {"entity": "publication", "iuid": "38586f75de7947afa759f06f240e3a9b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38586f75de7947afa759f06f240e3a9b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38586f75de7947afa759f06f240e3a9b"}}, "title": "Comparison of online learning designs during the COVID-19 pandemic within bioinformatics courses in higher education.", "authors": [{"family": "Abrahamsson", "given": "Sanna", "initials": "S"}, {"family": "D\u00e1vila L\u00f3pez", "given": "Marcela", "initials": "M"}], "type": "journal article", "published": "2021-07-12", "journal": {"title": "Bioinformatics", "issn": "1367-4811", "volume": "37", "issue": "Suppl_1", "pages": "i9-i15", "issn-l": null}, "abstract": "Due to the worldwide COVID-19 pandemic, new strategies had to be adopted to move from classroom-based education to online education, in a very short time. The lack of time to set up these strategies, hindered a proper design of online instructions and delivery of knowledge. Bioinformatics-related training and other onsite practical education, tend to rely on extensive practice, where students and instructors have a face-to-face interaction to improve the learning outcome. For these courses to maintain their high quality when adapted as online courses, different designs need to be tested and the students' perceptions need to be heard.\n\nThis study focuses on short bioinformatics-related courses for graduate students at the University of Gothenburg, Sweden, which were originally developed for onsite training. Once adapted as online courses, several modifications in their design were tested to obtain the best fitting learning strategy for the students. To improve the online learning experience, we propose a combination of: (i) short synchronized sessions, (ii) extended time for own and group practical work, (iii) recorded live lectures and (iv) increased opportunities for feedback in several formats.\n\nSupplementary data are available at Bioinformatics online.", "doi": "10.1093/bioinformatics/btab304", "pmid": "34252967", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "6319705"}], "notes": [], "created": "2021-08-06T07:36:14.851Z", "modified": "2021-08-06T07:48:18.065Z"}, {"entity": "publication", "iuid": "d2b62737826f4a37af9872b0e5c8caf6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d2b62737826f4a37af9872b0e5c8caf6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d2b62737826f4a37af9872b0e5c8caf6"}}, "title": "Study of SARS-CoV-2 transmission in urban environment by questionnaire and modeling for sustainable risk control.", "authors": [{"family": "Yu", "given": "Han", "initials": "H"}, {"family": "Ye", "given": "Xuying", "initials": "X"}, {"family": "Zhang", "given": "Minying", "initials": "M"}, {"family": "Zhang", "given": "Fenghao", "initials": "F"}, {"family": "Li", "given": "Yao", "initials": "Y"}, {"family": "Pan", "given": "Suxun", "initials": "S"}, {"family": "Li", "given": "Yuanling", "initials": "Y"}, {"family": "Yu", "given": "Hongbing", "initials": "H"}, {"family": "Lu", "given": "Chengzhi", "initials": "C"}], "type": "journal article", "published": "2021-07-10", "journal": {"title": "J Hazard Mater", "issn": "1873-3336", "issn-l": null, "volume": "420", "issue": null, "pages": "126621"}, "abstract": "Caused by SARS-CoV-2, COVID-19 has become a severe threaten to society and human health, its epidemic control emerges as long-term issue. A sustainable epidemic and environmental transmission risk control (SEERC) in urban area is urgently needed. This work aims to conduct a new investigation on the transmission risk of SARS-COV-2 as virus/hazardous material through various environmental medias, routes and regions in the entirely urban area for guiding the SEERC. Specifically, 5 routes in 28 regions (totally 140 scenarios) are considered. For a new perspective, the risk evaluation is conducted by the quantification of frontline medicals staffs' valuable experience in this work. 207 specialists responsible for the treatment of over 9000 infected patients are involved. The result showed that degree of risk was in the order of breath>contact-to-object>contact-to-human>intake>unknown. The modeling suggested source control as the prior measure for epidemic control. The combination of source control & mask wearing showed high efficiency in SEERC. The homeworking policy needed to cooperate with activity limitation to perform its efficiency. Subsequently, a new plan for SEERC was discussed. This work delivered significant information to researchers and decision makers for the further development of sustainable control for SARS-COV-2 spreading and COVID-19 epidemic.", "doi": "10.1016/j.jhazmat.2021.126621", "pmid": "34274804", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0304-3894(21)01586-7"}, {"db": "pmc", "key": "PMC8270745"}], "notes": [], "created": "2021-08-05T11:14:26.544Z", "modified": "2021-11-18T08:56:25.353Z"}, {"entity": "publication", "iuid": "f3652b085fec4a67a2878ce58ccfbbe6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f3652b085fec4a67a2878ce58ccfbbe6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f3652b085fec4a67a2878ce58ccfbbe6"}}, "title": "The one-sided explanations of a multifactorial coronavirus disease.", "authors": [{"family": "Ros\u00e9n", "given": "M\u00e5ns", "initials": "M", "orcid": "0000-0001-5295-0014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d544032f8b1c4fa1991916eda98aa5b9.json"}}, {"family": "Stenbeck", "given": "David", "initials": "D"}, {"family": "Stenbeck", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-07-09", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "pages": "14034948211026540", "issn-l": "1403-4948"}, "abstract": "Short-term interventions to suppress COVID-19 completely dominate the public, political and even the professional discussion on what explains observed differences in mortality and morbidity across countries. This leads to an exaggerated view of what such measures can accomplish. Factors such as housing and social conditions as well as travel patterns are equally important but neglected aspects of the COVID-19 development. A multifactorial disease needs a multivariate analytical approach.", "doi": "10.1177/14034948211026540", "pmid": "34240648", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:59:17.642Z", "modified": "2021-08-06T07:59:17.682Z"}, {"entity": "publication", "iuid": "19f38ab941cf4bbfb971c9e6fab34798", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19f38ab941cf4bbfb971c9e6fab34798.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19f38ab941cf4bbfb971c9e6fab34798"}}, "title": "The good, the bad and the ugly of children\u00b4s screen time during the COVID-19 pandemic.", "authors": [{"family": "Korhonen", "given": "Laura", "initials": "L", "orcid": "0000-0002-1837-5930", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a549aa5146734b40bd08f5f48a0ab366.json"}}], "type": "editorial", "published": "2021-07-09", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253"}, "abstract": null, "doi": "10.1111/apa.16012", "pmid": "34245034", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:52:35.947Z", "modified": "2021-08-06T07:56:46.829Z"}, {"entity": "publication", "iuid": "b97b058da45f40cd9d8bf05fd0f5bda9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b97b058da45f40cd9d8bf05fd0f5bda9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b97b058da45f40cd9d8bf05fd0f5bda9"}}, "title": "Self-Exclusion from Gambling-A Measure of COVID-19 Impact on Gambling in a Highly Online-Based Gambling Market?", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A", "orcid": "0000-0002-5800-8975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec14ecdcc0654d8ea864f64ce195752b.json"}}, {"family": "Widinghoff", "given": "Carolina", "initials": "C"}, {"family": "Berge", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2021-07-09", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "14", "pages": null}, "abstract": "The COVID-19 pandemic, and related changes of the gambling market, have been suspected to affect the risk of problem gambling. Despite media attention and political concern with this risk, study findings hitherto have been mixed. Voluntary self-exclusion from gambling was introduced on a national level in Sweden as a harm reduction tool in 2019, and this self-exclusion service in Sweden is a rare example of such an official, nationwide, multi-operator system. The present study aimed to evaluate whether short-term self-exclusion patterns were affected by different phases of COVID-19-related impacts on gambling markets in 2020. During the lock-down of sports in the spring months of 2020, three-month self-exclusion was unaffected, and one-month self-exclusion appeared to increase, though not more than in a recent period prior to COVID-19. Despite large differences in sports betting practices between women and men, self-exclusion patterns during COVID-19 were not apparently gender-specific. Altogether, self-exclusion from gambling, to date, does not appear to be affected by COVID-19-related changes in society, in contrast with beliefs about such changes producing greater help-seeking behavior in gamblers. Limitations are discussed, including the fact that in a recently introduced system, seasonality aspects and the autocorrelated nature of the data made substantial statistical measures unfeasible.", "doi": "10.3390/ijerph18147367", "pmid": "34299817", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph18147367"}, {"db": "pmc", "key": "PMC8305751"}], "notes": [], "created": "2021-08-05T07:07:30.294Z", "modified": "2021-11-18T08:54:37.444Z"}, {"entity": "publication", "iuid": "0bc0e45ee27f43388eea0bea6188ba6e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0bc0e45ee27f43388eea0bea6188ba6e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0bc0e45ee27f43388eea0bea6188ba6e"}}, "title": "Schools closed due to COVID-19 pandemic can be reopened early and safely.", "authors": [{"family": "Milerad", "given": "Josef", "initials": "J", "orcid": "0000-0003-1775-4602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/57d6b75491ed49a18ada88ae9d46e0a6.json"}}], "type": "editorial", "published": "2021-07-09", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253"}, "abstract": null, "doi": "10.1111/apa.16010", "pmid": "34245052", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:51:14.722Z", "modified": "2021-08-06T07:56:22.741Z"}, {"entity": "publication", "iuid": "3182957ca98c4962886b0eda0c9205a3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3182957ca98c4962886b0eda0c9205a3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3182957ca98c4962886b0eda0c9205a3"}}, "title": "Gender-specific estimates of sleep problems during the COVID-19 pandemic: Systematic review and meta-analysis.", "authors": [{"family": "Alimoradi", "given": "Zainab", "initials": "Z"}, {"family": "Gozal", "given": "David", "initials": "D"}, {"family": "Tsang", "given": "Hector W H", "initials": "HWH"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A", "orcid": "0000-0002-0433-0619", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07e3a9fa06004152bb4f194f4d2d1d8c.json"}}, {"family": "Ohayon", "given": "Maurice M", "initials": "MM"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-07-09", "journal": {"title": "J Sleep Res", "issn": "1365-2869", "issn-l": "0962-1105", "volume": null, "issue": null, "pages": "e13432"}, "abstract": "The outbreak of the novel coronavirus disease 2019 (COVID-19) changed lifestyles worldwide and subsequently induced individuals' sleep problems. Sleep problems have been demonstrated by scattered evidence among the current literature on COVID-19; however, little is known regarding the synthesised prevalence of sleep problems (i.e. insomnia symptoms and poor sleep quality) for males and females separately. The present systematic review and meta-analysis aimed to answer the important question regarding prevalence of sleep problems during the COVID-19 outbreak period between genders. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline and Newcastle-Ottawa Scale checklist, relevant studies with satisfactory methodological quality searched for in five academic databases (Scopus, PubMed Central, ProQuest, Web of Science , and EMBASE) were included and analysed. The protocol of the project was registered in the International Prospective Register of Systematic Reviews (PROSPERO; identification code CRD42020181644). A total of 54 papers (N = 67,722) in the female subgroup and 45 papers (N = 45,718) in the male subgroup were pooled in the meta-analysis. The corrected pooled estimated prevalence of sleep problems was 24% (95% confidence interval [CI] 19%-29%) for female participants and 27% (95% CI 24%-30%) for male participants. Although in both gender subgroups, patients with COVID-19, health professionals and general population showed the highest prevalence of sleep problems, it did not reach statistical significance. Based on multivariable meta-regression, both gender groups had higher prevalence of sleep problems during the lockdown period. Therefore, healthcare providers should pay attention to the sleep problems and take appropriate preventive action.", "doi": "10.1111/jsr.13432", "pmid": "34245055", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-08-06T07:50:54.687Z", "modified": "2021-11-18T08:51:42.937Z"}, {"entity": "publication", "iuid": "823bb9f54aa14eff88ccb2d6880fa2d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/823bb9f54aa14eff88ccb2d6880fa2d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/823bb9f54aa14eff88ccb2d6880fa2d7"}}, "title": "Development and validation of a tool to appraise guidelines on SARS-CoV-2 infection control strategies in healthcare workers.", "authors": [{"family": "Subramaniam", "given": "Ashwin", "initials": "A"}, {"family": "Ponnapa Reddy", "given": "Mallikarjuna", "initials": "M"}, {"family": "Kadam", "given": "Umesh", "initials": "U"}, {"family": "Zubarev", "given": "Alexander", "initials": "A"}, {"family": "Lim", "given": "Zheng", "initials": "Z"}, {"family": "Anstey", "given": "Chris", "initials": "C"}, {"family": "Bihari", "given": "Shailesh", "initials": "S"}, {"family": "Haji", "given": "Jumana", "initials": "J"}, {"family": "Luo", "given": "Jinghang", "initials": "J"}, {"family": "Mitra", "given": "Saikat", "initials": "S"}, {"family": "Ramanathan", "given": "Kollengode", "initials": "K"}, {"family": "Rajamani", "given": "Arvind", "initials": "A"}, {"family": "Rubulotta", "given": "Francesca", "initials": "F"}, {"family": "Svensk", "given": "Erik", "initials": "E"}, {"family": "Shekar", "given": "Kiran", "initials": "K"}], "type": "journal article", "published": "2021-07-09", "journal": {"title": "Aust Crit Care", "issn": "1036-7314", "issn-l": null}, "abstract": "Clinical guidelines on infection control strategies in healthcare workers (HCWs) play an important role in protecting them during the severe acute respiratory syndrome coronavirus 2 pandemic. Poorly constructed guidelines that are incomprehensive and/or ambiguous may compromise HCWs' safety.\n\nThe objective of this study was to develop and validate a tool to appraise guidelines on infection control strategies in HCWs based on the guidelines published early in the coronavirus disease 2019 pandemic.\n\nA three-stage, web-based, Delphi consensus-building process among a panel of diverse HCWs and healthcare managers was performed. The tool was validated by appraising 40 international, specialty-specific, and procedure-specific guidelines along with national guidelines from countries with a wide range of gross national income.\n\nOverall consensus (\u226575%) was reached at the end of three rounds for all six domains included in the tool. The Delphi panel recommended an ideal infection control guideline should encompass six domains: general characteristics (domain 1), engineering recommendations (domain 2), personal protective equipment (PPE) use (domain 3), and administrative aspects (domain 4-6) of infection control. The appraisal tool performed well across the six domains, and the inter-rater agreement was excellent for the 40 guidelines. All included guidelines performed relatively better in domains 1-3 than in domains 4-6, and this was more evident in guidelines originating from lower income countries.\n\nThe guideline appraisal tool was robust and easy to use. Engineering recommendations aspects of infection control, administrative measures that promote optimal PPE use, and HCW wellbeing were generally lacking in assessed guidelines. This tool may enable health systems to adopt high-quality HCW infection control guidelines during the severe acute respiratory syndrome coronavirus 2 pandemic and may also provide a framework for future guideline development.", "doi": "10.1016/j.aucc.2021.06.015", "pmid": "34404579", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1036-7314(21)00109-0"}], "notes": [], "created": "2021-08-20T12:22:10.265Z", "modified": "2021-08-20T12:22:34.716Z"}, {"entity": "publication", "iuid": "75228cad4a604941871dc8aa3b32d156", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/75228cad4a604941871dc8aa3b32d156.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/75228cad4a604941871dc8aa3b32d156"}}, "title": "Correction to 'Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy'.", "authors": [{"family": "Wacker", "given": "Anna", "initials": "A"}, {"family": "Weigand", "given": "Julia E", "initials": "JE", "orcid": "0000-0003-4247-1348", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5229ec08ce9242c19049804ff8a77085.json"}}, {"family": "Akabayov", "given": "Sabine R", "initials": "SR"}, {"family": "Altincekic", "given": "Nadide", "initials": "N"}, {"family": "Bains", "given": "Jasleen Kaur", "initials": "JK"}, {"family": "Banijamali", "given": "Elnaz", "initials": "E"}, {"family": "Binas", "given": "Oliver", "initials": "O"}, {"family": "Castillo-Martinez", "given": "Jesus", "initials": "J"}, {"family": "Cetiner", "given": "Erhan", "initials": "E"}, {"family": "Ceylan", "given": "Bet\u00fcl", "initials": "B"}, {"family": "Chiu", "given": "Liang-Yuan", "initials": "LY"}, {"family": "Davila-Calderon", "given": "Jesse", "initials": "J"}, {"family": "Dhamotharan", "given": "Karthikeyan", "initials": "K"}, {"family": "Duchardt-Ferner", "given": "Elke", "initials": "E"}, {"family": "Ferner", "given": "Jan", "initials": "J"}, {"family": "Frydman", "given": "Lucio", "initials": "L"}, {"family": "F\u00fcrtig", "given": "Boris", "initials": "B", "orcid": "0000-0001-6443-7656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5e0849167334290a5bd6691644783bf.json"}}, {"family": "Gallego", "given": "Jos\u00e9", "initials": "J", "orcid": "0000-0002-0627-6927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b188371610a46858542181b11863966.json"}}, {"family": "Gr\u00fcn", "given": "J Tassilo", "initials": "JT"}, {"family": "Hacker", "given": "Carolin", "initials": "C"}, {"family": "Haddad", "given": "Christina", "initials": "C"}, {"family": "H\u00e4hnke", "given": "Martin", "initials": "M"}, {"family": "Hengesbach", "given": "Martin", "initials": "M", "orcid": "0000-0001-9414-1602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa75083441294b4f8fe68b1a42fee601.json"}}, {"family": "Hiller", "given": "Fabian", "initials": "F"}, {"family": "Hohmann", "given": "Katharina F", "initials": "KF"}, {"family": "Hymon", "given": "Daniel", "initials": "D"}, {"family": "de Jesus", "given": "Vanessa", "initials": "V"}, {"family": "Jonker", "given": "Henry", "initials": "H"}, {"family": "Keller", "given": "Heiko", "initials": "H"}, {"family": "Knezic", "given": "Bozana", "initials": "B"}, {"family": "Landgraf", "given": "Tom", "initials": "T"}, {"family": "L\u00f6hr", "given": "Frank", "initials": "F"}, {"family": "Luo", "given": "Le", "initials": "L"}, {"family": "Mertinkus", "given": "Klara R", "initials": "KR"}, {"family": "Muhs", "given": "Christina", "initials": "C"}, {"family": "Novakovic", "given": "Mihajlo", "initials": "M"}, {"family": "Oxenfarth", "given": "Andreas", "initials": "A"}, {"family": "Palomino-Sch\u00e4tzlein", "given": "Martina", "initials": "M"}, {"family": "Petzold", "given": "Katja", "initials": "K"}, {"family": "Peter", "given": "Stephen A", "initials": "SA"}, {"family": "Pyper", "given": "Dennis J", "initials": "DJ"}, {"family": "Qureshi", "given": "Nusrat S", "initials": "NS"}, {"family": "Riad", "given": "Magdalena", "initials": "M"}, {"family": "Richter", "given": "Christian", "initials": "C"}, {"family": "Saxena", "given": "Krishna", "initials": "K"}, {"family": "Schamber", "given": "Tatjana", "initials": "T"}, {"family": "Scherf", "given": "Tali", "initials": "T"}, {"family": "Schlagnitweit", "given": "Judith", "initials": "J"}, {"family": "Schlundt", "given": "Andreas", "initials": "A", "orcid": "0000-0003-2254-7560", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/662b48aa496e4109aab02871f6b1d43d.json"}}, {"family": "Schnieders", "given": "Robbin", "initials": "R"}, {"family": "Schwalbe", "given": "Harald", "initials": "H", "orcid": "0000-0001-5693-7909", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32641f04b8504ac493d46947e87e4f59.json"}}, {"family": "Simba-Lahuasi", "given": "Alvaro", "initials": "A"}, {"family": "Sreeramulu", "given": "Sridhar", "initials": "S"}, {"family": "Stirnal", "given": "Elke", "initials": "E"}, {"family": "Sudakov", "given": "Alexey", "initials": "A"}, {"family": "Tants", "given": "Jan-Niklas", "initials": "JN"}, {"family": "Tolbert", "given": "Blanton S", "initials": "BS"}, {"family": "V\u00f6gele", "given": "Jennifer", "initials": "J"}, {"family": "Wei\u00df", "given": "Lena", "initials": "L"}, {"family": "Wirmer-Bartoschek", "given": "Julia", "initials": "J"}, {"family": "Wirtz Martin", "given": "Maria A", "initials": "MA"}, {"family": "W\u00f6hnert", "given": "Jens", "initials": "J", "orcid": "0000-0001-7193-401X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/611eebfc08f54e20b4dc9b881da010b8.json"}}, {"family": "Zetzsche", "given": "Heidi", "initials": "H"}], "type": "published erratum", "published": "2021-07-09", "journal": {"title": "Nucleic Acids Res", "issn": "1362-4962", "volume": "49", "issue": "12", "pages": "7204-7205", "issn-l": "0305-1048"}, "abstract": null, "doi": "10.1093/nar/gkab568", "pmid": "34161581", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8266613"}, {"db": "pii", "key": "6308495"}], "notes": [], "created": "2021-06-28T18:17:42.332Z", "modified": "2023-06-19T15:30:50.411Z"}, {"entity": "publication", "iuid": "d079fcc4919b45aba6636d41ad1bfaa8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d079fcc4919b45aba6636d41ad1bfaa8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d079fcc4919b45aba6636d41ad1bfaa8"}}, "title": "Baricitinib reduces 30-day mortality in older adults with moderate-to-severe COVID-19 pneumonia.", "authors": [{"family": "Abizanda", "given": "Pedro", "initials": "P"}, {"family": "Calbo Mayo", "given": "Juan Mar\u00eda", "initials": "JM"}, {"family": "Mas Romero", "given": "Marta", "initials": "M"}, {"family": "Cort\u00e9s Zamora", "given": "Elisa Bel\u00e9n", "initials": "EB"}, {"family": "Tabernero Sahuquillo", "given": "Mar\u00eda Teresa", "initials": "MT"}, {"family": "Romero Rizos", "given": "Luis", "initials": "L"}, {"family": "S\u00e1nchez-Jurado", "given": "Pedro Manuel", "initials": "PM"}, {"family": "S\u00e1nchez-Nievas", "given": "Gin\u00e9s", "initials": "G"}, {"family": "Campayo Escolano", "given": "Carlos", "initials": "C"}, {"family": "Ochoa Serrano", "given": "Alba", "initials": "A"}, {"family": "S\u00e1nchez-Flor Alfaro", "given": "Victoria", "initials": "V"}, {"family": "L\u00f3pez Bru", "given": "Rita", "initials": "R"}, {"family": "G\u00f3mez Ballesteros", "given": "Cristina", "initials": "C"}, {"family": "Caldevilla Bernardo", "given": "David", "initials": "D"}, {"family": "Callejas Gonz\u00e1lez", "given": "Francisco Javier", "initials": "FJ"}, {"family": "Andr\u00e9s-Pretel", "given": "Fernando", "initials": "F"}, {"family": "Lauschke", "given": "Volker Martin", "initials": "VM"}, {"family": "Stebbing", "given": "Justin", "initials": "J"}], "type": "journal article", "published": "2021-07-08", "journal": {"title": "J Am Geriatr Soc", "issn": "0002-8614", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Older adults are at the highest risk of severe disease and death due to COVID-19. Randomized data have shown that baricitinib improves outcomes in these patients, but focused stratified analyses of geriatric cohorts are lacking. Our objective was to analyze the efficacy of baricitinib in older adults with COVID-19 moderate-to-severe pneumonia.\r\n\r\nThis is a propensity score [PS]-matched retrospective cohort study. Patients from the COVID-AGE and Alba-Score cohorts, hospitalized for moderate-to-severe COVID-19 pneumonia, were categorized in two age brackets of age <70 years old (86 with baricitinib and 86 PS-matched controls) or \u226570 years old (78 on baricitinib and 78 PS-matched controls). Thirty-day mortality rates were analyzed with Kaplan-Meier and Cox proportional hazard models.\r\n\r\nMean age was 79.1 for those \u226570 years and 58.9 for those <70. Exactly 29.6% were female. Treatment with baricitinib resulted in a significant reduction in death from any cause by 48% in patients aged 70 or older, an 18.5% reduction in 30-day absolute mortality risk (n/N: 16/78 [20.5%] baricitinib, 30/78 [38.5%] in PS-matched controls, p < 0.001) and a lower 30-day adjusted fatality rate (HR 0.21; 95% CI 0.09-0.47; p < 0.001). Beneficial effects on mortality were also observed in the age group <70 (8.1% reduction in 30-day absolute mortality risk; HR 0.14; 95% CI 0.03-0.64; p = 0.011).\r\n\r\nBaricitinib is associated with an absolute mortality risk reduction of 18.5% in adults older than 70 years hospitalized with COVID-19 pneumonia.", "doi": "10.1111/jgs.17357", "pmid": "34235720", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-06T08:21:28.943Z", "modified": "2021-08-23T14:38:39.781Z"}, {"entity": "publication", "iuid": "f36f197d53a64a43902196bf0722814e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f36f197d53a64a43902196bf0722814e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f36f197d53a64a43902196bf0722814e"}}, "title": "Swedish nationwide time series analysis of influenza and suicide deaths from 1910 to 1978.", "authors": [{"family": "R\u00fcck", "given": "Christian", "initials": "C", "orcid": "0000-0002-8742-0168", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1183965f649f4bf08e86186f5ec30519.json"}}, {"family": "Mataix-Cols", "given": "David", "initials": "D"}, {"family": "Malki", "given": "Kinda", "initials": "K"}, {"family": "Adler", "given": "Mats", "initials": "M"}, {"family": "Flygare", "given": "Oskar", "initials": "O", "orcid": "0000-0002-2017-3940", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b7ed40871394a0d993b094b809a1e70.json"}}, {"family": "Runeson", "given": "Bo", "initials": "B"}, {"family": "Sidorchuk", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-07-07", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "7", "pages": "e049302"}, "abstract": "There is concern that the COVID-19 pandemic will be associated with an increase in suicides, but evidence supporting a link between pandemics and suicide is limited. Using data from the three influenza pandemics of the 20th century, we aimed to investigate whether an association exists between influenza deaths and suicide deaths.\r\n\r\nTime series analysis.\r\n\r\nSweden.\r\n\r\nDeaths from influenza and suicides extracted from the Statistical Yearbook of Sweden for 1910-1978, covering three pandemics (the Spanish influenza, the Asian influenza and the Hong Kong influenza).\r\n\r\nAnnual suicide rates in Sweden among the whole population, men and women. Non-linear autoregressive distributed lag models was implemented to explore if there is a short-term and/or long-term relationship of increases and decreases in influenza death rates with suicide rates during 1910-1978.\r\n\r\nBetween 1910 and 1978, there was no evidence of either short-term or long-term significant associations between influenza death rates and changes in suicides (\u03b2 coefficients of 0.00002, p=0.931 and \u03b2=0.00103, p=0.764 for short-term relationship of increases and decreases in influenza death rates, respectively, with suicide rates, and \u03b2=-0.0002, p=0.998 and \u03b2=0.00211, p=0.962 for long-term relationship of increases and decreases in influenza death rates, respectively, with suicide rates). The same pattern emerged in separate analyses for men and women.\r\n\r\nWe found no evidence of short-term or long-term association between influenza death rates and suicide death rates across three 20th century pandemics.", "doi": "10.1136/bmjopen-2021-049302", "pmid": "34233997", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-049302"}, {"db": "pmc", "key": "PMC8266430"}, {"db": "URL", "key": "https://bmjopen.bmj.com/content/bmjopen/suppl/2021/07/07/bmjopen-2021-049302.DC1/bmjopen-2021-049302supp001_data_supplement.pdf", "description": "Numbers of deaths by influenza and suicide and total population for 1910-1978"}], "notes": [], "created": "2021-08-06T08:30:29.374Z", "modified": "2021-11-18T08:47:06.477Z"}, {"entity": "publication", "iuid": "cd0c0576dfbd45aba076d15ccad48f58", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd0c0576dfbd45aba076d15ccad48f58.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd0c0576dfbd45aba076d15ccad48f58"}}, "title": "Demographic and clinical characteristics of severe Covid-19 infections: a cross-sectional study from Mashhad University of Medical Sciences, Iran.", "authors": [{"family": "Goshayeshi", "given": "Ladan", "initials": "L"}, {"family": "Akbari Rad", "given": "Mina", "initials": "M"}, {"family": "Bergquist", "given": "Robert", "initials": "R"}, {"family": "Allahyari", "given": "Abolghasem", "initials": "A"}, {"family": "Hashemzadeh", "given": "Kamila", "initials": "K"}, {"family": "MUMS Covid-19 Research Team", "given": "", "initials": ""}, {"family": "Hoseini", "given": "Benyamin", "initials": "B", "orcid": "0000-0002-0355-6181", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a56dc3b14f8430fa3f011ef206976f4.json"}}], "type": "journal article", "published": "2021-07-07", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "issn-l": null, "volume": "21", "issue": "1", "pages": "656"}, "abstract": "Coronavirus Disease 2019 (Covid-19) is expanding worldwide. The characteristics of this infection in patients varies from country to country. To move forward, clinical data on infected patients are needed. Here, we report a comparison between fatalities and recovery of patients with severe Covid-19, based on demographic and clinical characteristics.\r\n\r\nBetween 5 March and 12 May 2020 in Mashhad, Iran, 1278 of 4000 suspected Covid-19 patients were confirmed positive by real-time reverse-transcriptase-polymerase-chain-reaction assay of upper respiratory specimens. We compared the demographic, exposure history and clinical symptoms of 925 survivors and 353 fatal cases with confirmed disease.\r\n\r\nMean (SD) age for all confirmed patients was 56.9 (18.7) years, 67.1 (15.9) years in fatal cases and 53.0 (18.3) years in survivors. Multivariate logistic regression analysis showed that the outcome of patients was associated with age (odds ratio = 1.049, P = 0.0001, 95% CI = 1.040-1.057). Despite a high burden of Covid-19 infections in the 30-39 and 40-49 year age groups, most of these (89.6 and 87.2%, respectively) recovered. The median (IQR) duration of hospitalization was 9.0 (6.0-14.0) days. The most prevalent co-morbidities were cardiovascular disorders (21%) and diabetes (16.3%). Dyspnoea (72.7%), cough (68.1%) and fever (63.8%) were the most frequent clinical symptoms. Healthcare workers, of whom two (3%) died, comprised 5.2% of infected cases. Combination antiviral and antibiotic therapy was used in 43.0% of cases.\r\n\r\nThe characteristics of severe Covid-19 varied substantially between fatal cases and survivors, with diabetes and cardiovascular disorders the most prevalent co-morbidities. In contrast to other studies, there were a higher number of fatalities in younger patients in our setting.", "doi": "10.1186/s12879-021-06363-6", "pmid": "34233638", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12879-021-06363-6"}, {"db": "pmc", "key": "PMC8261035"}], "notes": [], "created": "2021-08-06T08:33:39.532Z", "modified": "2021-11-18T08:22:21.313Z"}, {"entity": "publication", "iuid": "5f14b7f1e44e4454be7287fb1a635e96", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f14b7f1e44e4454be7287fb1a635e96.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f14b7f1e44e4454be7287fb1a635e96"}}, "title": "An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism.", "authors": [{"family": "Razzaq", "given": "Misbah", "initials": "M"}, {"family": "Iglesias", "given": "Maria Jesus", "initials": "MJ"}, {"family": "Ibrahim-Kosta", "given": "Manal", "initials": "M"}, {"family": "Goumidi", "given": "Louisa", "initials": "L"}, {"family": "Soukarieh", "given": "Omar", "initials": "O"}, {"family": "Proust", "given": "Carole", "initials": "C"}, {"family": "Roux", "given": "Maguelonne", "initials": "M"}, {"family": "Suchon", "given": "Pierre", "initials": "P"}, {"family": "Boland", "given": "Anne", "initials": "A"}, {"family": "Daiain", "given": "Delphine", "initials": "D"}, {"family": "Olaso", "given": "Robert", "initials": "R"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Thalin", "given": "Charlotte", "initials": "C"}, {"family": "Butler", "given": "Lynn", "initials": "L"}, {"family": "Deleuze", "given": "Jean-Fran\u00e7ois", "initials": "J"}, {"family": "Odeberg", "given": "Jacob", "initials": "J"}, {"family": "Morange", "given": "Pierre-Emmanuel", "initials": "P"}, {"family": "Tr\u00e9gou\u00ebt", "given": "David-Alexandre", "initials": "D"}], "type": "journal article", "published": "2021-07-07", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "14015"}, "abstract": "Venous thromboembolism is the third common cardiovascular disease and is composed of two entities, deep vein thrombosis (DVT) and its potential fatal form, pulmonary embolism (PE). While PE is observed in ~ 40% of patients with documented DVT, there is limited biomarkers that can help identifying patients at high PE risk. To fill this need, we implemented a two hidden-layers artificial neural networks (ANN) on 376 antibodies and 19 biological traits measured in the plasma of 1388 DVT patients, with or without PE, of the MARTHA study. We used the LIME algorithm to obtain a linear approximate of the resulting ANN prediction model. As MARTHA patients were typed for genotyping DNA arrays, a genome wide association study (GWAS) was conducted on the LIME estimate. Detected single nucleotide polymorphisms (SNPs) were tested for association with PE risk in MARTHA. Main findings were replicated in the EOVT study composed of 143 PE patients and 196 DVT only patients. The derived ANN model for PE achieved an accuracy of 0.89 and 0.79 in our training and testing sets, respectively. A GWAS on the LIME approximate identified a strong statistical association peak (rs1424597: p = 5.3 \u00d7 10-7) at the PLXNA4 locus. Homozygote carriers for the rs1424597-A allele were then more frequently observed in PE than in DVT patients from the MARTHA (2% vs. 0.4%, p = 0.005) and the EOVT (3% vs. 0%, p = 0.013) studies. In a sample of 112 COVID-19 patients known to have endotheliopathy leading to acute lung injury and an increased risk of PE, decreased PLXNA4 levels were associated (p = 0.025) with worsened respiratory function. Using an original integrated proteomics and genetics strategy, we identified PLXNA4 as a new susceptibility gene for PE whose exact role now needs to be further elucidated.", "doi": "10.1038/s41598-021-93390-7", "pmid": "34234248", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-93390-7"}, {"db": "pmc", "key": "PMC8263618"}, {"db": "URL", "key": "https://zenodo.org/record/4280776#.YCEVVeoo-vc.", "description": "https://zenodo.org/record/4280776#.YCEVVeoo-vc."}], "notes": [], "created": "2021-08-06T08:25:57.051Z", "modified": "2022-02-14T17:54:22.941Z"}, {"entity": "publication", "iuid": "c6e34c3c36b54441ad20f3ed4f9ffd0e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c6e34c3c36b54441ad20f3ed4f9ffd0e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c6e34c3c36b54441ad20f3ed4f9ffd0e"}}, "title": "Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis.", "authors": [{"family": "Goubet", "given": "Anne-Ga\u00eblle", "initials": "AG", "orcid": "0000-0003-3431-3067", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/003b572826744aa4a622638867e8473b.json"}}, {"family": "Dubuisson", "given": "Agathe", "initials": "A", "orcid": "0000-0002-7526-0769", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bb31612735e14dcda96cda1a050505af.json"}}, {"family": "Geraud", "given": "Arthur", "initials": "A"}, {"family": "Danlos", "given": "Fran\u00e7ois-Xavier", "initials": "FX"}, {"family": "Terrisse", "given": "Safae", "initials": "S"}, {"family": "Silva", "given": "Carolina Alves Costa", "initials": "CAC"}, {"family": "Drubay", "given": "Damien", "initials": "D"}, {"family": "Touri", "given": "Lea", "initials": "L"}, {"family": "Picard", "given": "Marion", "initials": "M"}, {"family": "Mazzenga", "given": "Marine", "initials": "M"}, {"family": "Silvin", "given": "Aymeric", "initials": "A"}, {"family": "Dunsmore", "given": "Garett", "initials": "G"}, {"family": "Haddad", "given": "Yacine", "initials": "Y"}, {"family": "Pizzato", "given": "Eugenie", "initials": "E"}, {"family": "Ly", "given": "Pierre", "initials": "P"}, {"family": "Flament", "given": "Caroline", "initials": "C"}, {"family": "Melenotte", "given": "Cl\u00e9a", "initials": "C"}, {"family": "Solary", "given": "Eric", "initials": "E", "orcid": "0000-0002-8629-1341", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5c0dc972ff945478e729c6ec852a31d.json"}}, {"family": "Fontenay", "given": "Michaela", "initials": "M"}, {"family": "Garcia", "given": "Gabriel", "initials": "G"}, {"family": "Balleyguier", "given": "Corinne", "initials": "C"}, {"family": "Lassau", "given": "Nathalie", "initials": "N"}, {"family": "Maeurer", "given": "Markus", "initials": "M"}, {"family": "Grajeda-Iglesias", "given": "Claudia", "initials": "C"}, {"family": "Nirmalathasan", "given": "Nitharsshini", "initials": "N"}, {"family": "Aprahamian", "given": "Fanny", "initials": "F"}, {"family": "Durand", "given": "Sylv\u00e8re", "initials": "S"}, {"family": "Kepp", "given": "Oliver", "initials": "O", "orcid": "0000-0002-6081-9558", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f9c6472b9f7440289a5d69e4c3ce4242.json"}}, {"family": "Ferrere", "given": "Gladys", "initials": "G"}, {"family": "Thelemaque", "given": "Cassandra", "initials": "C"}, {"family": "Lahmar", "given": "Imran", "initials": "I"}, {"family": "Fahrner", "given": "Jean-Eudes", "initials": "JE", "orcid": "0000-0001-6581-8418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/377e7032a04e48889630c1b3b1752bc7.json"}}, {"family": "Meziani", "given": "Lydia", "initials": "L"}, {"family": "Ahmed-Belkacem", "given": "Abdelhakim", "initials": "A", "orcid": "0000-0001-6489-5091", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6210518b0774ba49795f0f323b95dcf.json"}}, {"family": "Sa\u00efdani", "given": "Nadia", "initials": "N"}, {"family": "La Scola", "given": "Bernard", "initials": "B"}, {"family": "Raoult", "given": "Didier", "initials": "D"}, {"family": "Gentile", "given": "St\u00e9phanie", "initials": "S"}, {"family": "Cortaredona", "given": "S\u00e9bastien", "initials": "S"}, {"family": "Ippolito", "given": "Giuseppe", "initials": "G", "orcid": "0000-0002-1076-2979", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e11491db391a466aa783fbebfb315b4e.json"}}, {"family": "Lelouvier", "given": "Benjamin", "initials": "B"}, {"family": "Roulet", "given": "Alain", "initials": "A"}, {"family": "Andre", "given": "Fabrice", "initials": "F"}, {"family": "Barlesi", "given": "Fabrice", "initials": "F"}, {"family": "Soria", "given": "Jean-Charles", "initials": "JC"}, {"family": "Pradon", "given": "Caroline", "initials": "C"}, {"family": "Gallois", "given": "Emmanuelle", "initials": "E"}, {"family": "Pommeret", "given": "Fanny", "initials": "F"}, {"family": "Colomba", "given": "Emeline", "initials": "E"}, {"family": "Ginhoux", "given": "Florent", "initials": "F", "orcid": "0000-0002-2857-7755", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/71216e36b29a430b9740ad40de938a22.json"}}, {"family": "Kazandjian", "given": "Suzanne", "initials": "S"}, {"family": "Elkrief", "given": "Arielle", "initials": "A"}, {"family": "Routy", "given": "Bertrand", "initials": "B"}, {"family": "Miyara", "given": "Makoto", "initials": "M"}, {"family": "Gorochov", "given": "Guy", "initials": "G"}, {"family": "Deutsch", "given": "Eric", "initials": "E", "orcid": "0000-0002-8223-3697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09cfd1799b094229bb96399296b44812.json"}}, {"family": "Albiges", "given": "Laurence", "initials": "L"}, {"family": "Stoclin", "given": "Annabelle", "initials": "A"}, {"family": "Gachot", "given": "Bertrand", "initials": "B"}, {"family": "Florin", "given": "Anne", "initials": "A"}, {"family": "Merad", "given": "Mansouria", "initials": "M"}, {"family": "Scotte", "given": "Florian", "initials": "F"}, {"family": "Assaad", "given": "Souad", "initials": "S"}, {"family": "Kroemer", "given": "Guido", "initials": "G", "orcid": "0000-0002-9334-4405", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d17de2122d0429eaa48a733bf2ad28e.json"}}, {"family": "Blay", "given": "Jean-Yves", "initials": "JY", "orcid": "0000-0001-7190-120X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0021df4cfc98475db66480f47f20f6ed.json"}}, {"family": "Marabelle", "given": "Aur\u00e9lien", "initials": "A", "orcid": "0000-0002-5816-3019", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dfe92c547ebd4c5a9915777c1b1580b5.json"}}, {"family": "Griscelli", "given": "Frank", "initials": "F"}, {"family": "Zitvogel", "given": "Laurence", "initials": "L", "orcid": "0000-0003-1596-0998", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b10947c1a2b4884b3f502625a28c5e0.json"}}, {"family": "Derosa", "given": "Lisa", "initials": "L"}], "type": "journal article", "published": "2021-07-06", "journal": {"title": "Cell Death Differ", "issn": "1476-5403", "issn-l": null}, "abstract": "Patients with cancer are at higher risk of severe coronavirus infectious disease 2019 (COVID-19), but the mechanisms underlying virus-host interactions during cancer therapies remain elusive. When comparing nasopharyngeal swabs from cancer and noncancer patients for RT-qPCR cycle thresholds measuring acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in 1063 patients (58% with cancer), we found that malignant disease favors the magnitude and duration of viral RNA shedding concomitant with prolonged serum elevations of type 1 IFN that anticorrelated with anti-RBD IgG antibodies. Cancer patients with a prolonged SARS-CoV-2 RNA detection exhibited the typical immunopathology of severe COVID-19 at the early phase of infection including circulation of immature neutrophils, depletion of nonconventional monocytes, and a general lymphopenia that, however, was accompanied by a rise in plasmablasts, activated follicular T-helper cells, and non-naive Granzyme B+FasL+, EomeshighTCF-1high, PD-1+CD8+ Tc1 cells. Virus-induced lymphopenia worsened cancer-associated lymphocyte loss, and low lymphocyte counts correlated with chronic SARS-CoV-2 RNA shedding, COVID-19 severity, and a higher risk of cancer-related death in the first and second surge of the pandemic. Lymphocyte loss correlated with significant changes in metabolites from the polyamine and biliary salt pathways as well as increased blood DNA from Enterobacteriaceae and Micrococcaceae gut family members in long-term viral carriers. We surmise that cancer therapies may exacerbate the paradoxical association between lymphopenia and COVID-19-related immunopathology, and that the prevention of COVID-19-induced lymphocyte loss may reduce cancer-associated death.", "doi": "10.1038/s41418-021-00817-9", "pmid": "34230615", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41418-021-00817-9"}, {"db": "pmc", "key": "PMC8259103"}], "notes": [], "created": "2021-08-06T08:35:17.454Z", "modified": "2021-08-06T08:35:17.732Z"}, {"entity": "publication", "iuid": "335924efcd6347e3b429b4cd0e13559e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/335924efcd6347e3b429b4cd0e13559e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/335924efcd6347e3b429b4cd0e13559e"}}, "title": "Mendelian randomization analysis provides causality of smoking on the expression of ACE2, a putative SARS-CoV-2 receptor.", "authors": [{"family": "Liu", "given": "Hui", "initials": "H", "orcid": "0000-0002-5531-3640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/834c6d4bd0fe438890f5b0cae725692e.json"}}, {"family": "Xin", "given": "Junyi", "initials": "J", "orcid": "0000-0001-6677-3936", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05e1800a0c744052a2302ae98907dc4b.json"}}, {"family": "Cai", "given": "Sheng", "initials": "S"}, {"family": "Jiang", "given": "Xia", "initials": "X", "orcid": "0000-0001-5878-8986", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d87c42578c2b4d34bdcd126c84bdef52.json"}}], "type": "journal article", "published": "2021-07-06", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "10", "issn-l": null}, "abstract": "To understand a causal role of modifiable lifestyle factors in angiotensin-converting enzyme 2 (ACE2) expression (a putative severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] receptor) across 44 human tissues/organs, and in coronavirus disease 2019 (COVID-19) susceptibility and severity, we conducted a phenome-wide two-sample Mendelian randomization (MR) study.\n\nMore than 500 genetic variants were used as instrumental variables to predict smoking and alcohol consumption. Inverse-variance weighted approach was adopted as the primary method to estimate a causal association, while MR-Egger regression, weighted median, and MR pleiotropy residual sum and outlier (MR-PRESSO) were performed to identify potential horizontal pleiotropy.\n\nWe found that genetically predicted smoking intensity significantly increased ACE2 expression in thyroid (\u03b2=1.468, p=1.8\u00d710-8), and increased ACE2 expression in adipose, brain, colon, and liver with nominal significance. Additionally, genetically predicted smoking initiation significantly increased the risk of COVID-19 onset (odds ratio=1.14, p=8.7\u00d710-5). No statistically significant result was observed for alcohol consumption.\n\nOur work demonstrates an important role of smoking, measured by both status and intensity, in the susceptibility to COVID-19.\n\nXJ is supported by research grants from the Swedish Research Council (VR-2018-02247) and Swedish Research Council for Health, Working Life and Welfare (FORTE-2020-00884).", "doi": "10.7554/eLife.64188", "pmid": "34227468", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "64188"}, {"db": "pmc", "key": "PMC8282334"}], "notes": [], "created": "2021-08-06T08:40:08.264Z", "modified": "2021-08-06T08:40:19.359Z"}, {"entity": "publication", "iuid": "4ee333715e0a46dd95a2041abd266fbd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ee333715e0a46dd95a2041abd266fbd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ee333715e0a46dd95a2041abd266fbd"}}, "title": "Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis.", "authors": [{"family": "WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group", "given": "", "initials": ""}, {"family": "Shankar-Hari", "given": "Manu", "initials": "M"}, {"family": "Vale", "given": "Claire L", "initials": "CL"}, {"family": "Godolphin", "given": "Peter J", "initials": "PJ"}, {"family": "Fisher", "given": "David", "initials": "D"}, {"family": "Higgins", "given": "Julian P T", "initials": "JPT"}, {"family": "Spiga", "given": "Francesca", "initials": "F"}, {"family": "Savovic", "given": "Jelena", "initials": "J"}, {"family": "Tierney", "given": "Jayne", "initials": "J"}, {"family": "Baron", "given": "Gabriel", "initials": "G"}, {"family": "Benbenishty", "given": "Julie S", "initials": "JS"}, {"family": "Berry", "given": "Lindsay R", "initials": "LR"}, {"family": "Broman", "given": "Niklas", "initials": "N"}, {"family": "Cavalcanti", "given": "Alexandre Biasi", "initials": "AB"}, {"family": "Colman", "given": "Roos", "initials": "R"}, {"family": "De Buyser", "given": "Stefanie L", "initials": "SL"}, {"family": "Derde", "given": "Lennie P G", "initials": "LPG"}, {"family": "Domingo", "given": "Pere", "initials": "P"}, {"family": "Omar", "given": "Sharifah Faridah", "initials": "SF"}, {"family": "Fernandez-Cruz", "given": "Ana", "initials": "A"}, {"family": "Feuth", "given": "Thijs", "initials": "T"}, {"family": "Garcia", "given": "Felipe", "initials": "F"}, {"family": "Garcia-Vicuna", "given": "Rosario", "initials": "R"}, {"family": "Gonzalez-Alvaro", "given": "Isidoro", "initials": "I"}, {"family": "Gordon", "given": "Anthony C", "initials": "AC"}, {"family": "Haynes", "given": "Richard", "initials": "R"}, {"family": "Hermine", "given": "Olivier", "initials": "O"}, {"family": "Horby", "given": "Peter W", "initials": "PW"}, {"family": "Horick", "given": "Nora K", "initials": "NK"}, {"family": "Kumar", "given": "Kuldeep", "initials": "K"}, {"family": "Lambrecht", "given": "Bart N", "initials": "BN"}, {"family": "Landray", "given": "Martin J", "initials": "MJ"}, {"family": "Leal", "given": "Lorna", "initials": "L"}, {"family": "Lederer", "given": "David J", "initials": "DJ"}, {"family": "Lorenzi", "given": "Elizabeth", "initials": "E"}, {"family": "Mariette", "given": "Xavier", "initials": "X"}, {"family": "Merchante", "given": "Nicolas", "initials": "N"}, {"family": "Misnan", "given": "Nor Arisah", "initials": "NA"}, {"family": "Mohan", "given": "Shalini V", "initials": "SV"}, {"family": "Nivens", "given": "Michael C", "initials": "MC"}, {"family": "Oksi", "given": "Jarmo", "initials": "J"}, {"family": "Perez-Molina", "given": "Jose A", "initials": "JA"}, {"family": "Pizov", "given": "Reuven", "initials": "R"}, {"family": "Porcher", "given": "Raphael", "initials": "R"}, {"family": "Postma", "given": "Simone", "initials": "S"}, {"family": "Rajasuriar", "given": "Reena", "initials": "R"}, {"family": "Ramanan", "given": "Athimalaipet V", "initials": "AV"}, {"family": "Ravaud", "given": "Philippe", "initials": "P"}, {"family": "Reid", "given": "Pankti D", "initials": "PD"}, {"family": "Rutgers", "given": "Abraham", "initials": "A"}, {"family": "Sancho-Lopez", "given": "Aranzazu", "initials": "A"}, {"family": "Seto", "given": "Todd B", "initials": "TB"}, {"family": "Sivapalasingam", "given": "Sumathi", "initials": "S"}, {"family": "Soin", "given": "Arvinder Singh", "initials": "AS"}, {"family": "Staplin", "given": "Natalie", "initials": "N"}, {"family": "Stone", "given": "John H", "initials": "JH"}, {"family": "Strohbehn", "given": "Garth W", "initials": "GW"}, {"family": "Sunden-Cullberg", "given": "Jonas", "initials": "J"}, {"family": "Torre-Cisneros", "given": "Julian", "initials": "J"}, {"family": "Tsai", "given": "Larry W", "initials": "LW"}, {"family": "van Hoogstraten", "given": "Hubert", "initials": "H"}, {"family": "van Meerten", "given": "Tom", "initials": "T"}, {"family": "Veiga", "given": "Viviane Cordeiro", "initials": "VC"}, {"family": "Westerweel", "given": "Peter E", "initials": "PE"}, {"family": "Murthy", "given": "Srinivas", "initials": "S"}, {"family": "Diaz", "given": "Janet V", "initials": "JV"}, {"family": "Marshall", "given": "John C", "initials": "JC"}, {"family": "Sterne", "given": "Jonathan A C", "initials": "JAC"}], "type": "journal article", "published": "2021-07-06", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484"}, "abstract": "Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized for COVID-19 have variously reported benefit, no effect, and harm.\n\nTo estimate the association between administration of IL-6 antagonists compared with usual care or placebo and 28-day all-cause mortality and other outcomes.\n\nTrials were identified through systematic searches of electronic databases between October 2020 and January 2021. Searches were not restricted by trial status or language. Additional trials were identified through contact with experts.\n\nEligible trials randomly assigned patients hospitalized for COVID-19 to a group in whom IL-6 antagonists were administered and to a group in whom neither IL-6 antagonists nor any other immunomodulators except corticosteroids were administered. Among 72 potentially eligible trials, 27 (37.5%) met study selection criteria.\n\nIn this prospective meta-analysis, risk of bias was assessed using the Cochrane Risk of Bias Assessment Tool. Inconsistency among trial results was assessed using the I2 statistic. The primary analysis was an inverse variance-weighted fixed-effects meta-analysis of odds ratios (ORs) for 28-day all-cause mortality.\n\nThe primary outcome measure was all-cause mortality at 28 days after randomization. There were 9 secondary outcomes including progression to invasive mechanical ventilation or death and risk of secondary infection by 28 days.\n\nA total of 10 930 patients (median age, 61 years [range of medians, 52-68 years]; 3560 [33%] were women) participating in 27 trials were included. By 28 days, there were 1407 deaths among 6449 patients randomized to IL-6 antagonists and 1158 deaths among 4481 patients randomized to usual care or placebo (summary OR, 0.86 [95% CI, 0.79-0.95]; P = .003 based on a fixed-effects meta-analysis). This corresponds to an absolute mortality risk of 22% for IL-6 antagonists compared with an assumed mortality risk of 25% for usual care or placebo. The corresponding summary ORs were 0.83 (95% CI, 0.74-0.92; P < .001) for tocilizumab and 1.08 (95% CI, 0.86-1.36; P = .52) for sarilumab. The summary ORs for the association with mortality compared with usual care or placebo in those receiving corticosteroids were 0.77 (95% CI, 0.68-0.87) for tocilizumab and 0.92 (95% CI, 0.61-1.38) for sarilumab. The ORs for the association with progression to invasive mechanical ventilation or death, compared with usual care or placebo, were 0.77 (95% CI, 0.70-0.85) for all IL-6 antagonists, 0.74 (95% CI, 0.66-0.82) for tocilizumab, and 1.00 (95% CI, 0.74-1.34) for sarilumab. Secondary infections by 28 days occurred in 21.9% of patients treated with IL-6 antagonists vs 17.6% of patients treated with usual care or placebo (OR accounting for trial sample sizes, 0.99; 95% CI, 0.85-1.16).\n\nIn this prospective meta-analysis of clinical trials of patients hospitalized for COVID-19, administration of IL-6 antagonists, compared with usual care or placebo, was associated with lower 28-day all-cause mortality.\n\nPROSPERO Identifier: CRD42021230155.", "doi": "10.1001/jama.2021.11330", "pmid": "34228774", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "2781880"}, {"db": "pmc", "key": "PMC8261689"}], "notes": [], "created": "2021-08-06T08:36:54.854Z", "modified": "2021-08-06T08:37:13.476Z"}, {"entity": "publication", "iuid": "a6dcc2a2bf4a4852b94c061b5e660397", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6dcc2a2bf4a4852b94c061b5e660397.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6dcc2a2bf4a4852b94c061b5e660397"}}, "title": "SARS-CoV-2-specific humoral and cellular immunity persists through 9 months irrespective of COVID-19 severity at hospitalisation.", "authors": [{"family": "Sandberg", "given": "John Tyler", "initials": "JT", "orcid": "0000-0001-6747-6933", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dfe4b6f5f2f24420bd78d7ae9b71e2d4.json"}}, {"family": "Varnait\u0117", "given": "Renata", "initials": "R", "orcid": "0000-0001-9391-9291", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05a03781d1c84aad85895298c193c575.json"}}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f2dc27d02294a15a6f691be6aab641f.json"}}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Muvva", "given": "Jagadeeswara R", "initials": "JR"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Garc\u00eda", "given": "Marina", "initials": "M", "orcid": "0000-0002-9130-3933", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5b109d7a54e4c05a48e0f21c4432be6.json"}}, {"family": "Dzidic", "given": "Majda", "initials": "M"}, {"family": "Folkesson", "given": "Elin", "initials": "E"}, {"family": "Skagerberg", "given": "Magdalena", "initials": "M"}, {"family": "Ahl\u00e9n", "given": "Gustaf", "initials": "G"}, {"family": "Frelin", "given": "Lars", "initials": "L"}, {"family": "S\u00e4llberg", "given": "Matti", "initials": "M"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Blom", "given": "Kim", "initials": "K", "orcid": "0000-0002-5286-3735", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/636cd4b9609b43d9b6ddbb10a7e2553a.json"}}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Karolinska COVID\u201019 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-07-05", "journal": {"title": "Clin Transl Immunol", "issn": "2050-0068", "issn-l": null, "volume": "10", "issue": "7", "pages": "e1306"}, "abstract": "Humoral and cellular immunity to SARS-CoV-2 following COVID-19 will likely contribute to protection from reinfection or severe disease. It is therefore important to characterise the initiation and persistence of adaptive immunity to SARS-CoV-2 amidst the ongoing pandemic.\n\nHere, we conducted a longitudinal study on hospitalised moderate and severe COVID-19 patients from the acute phase of disease into convalescence at 5 and 9 months post-symptom onset. Utilising flow cytometry, serological assays as well as B cell and T cell FluoroSpot assays, we assessed the magnitude and specificity of humoral and cellular immune responses during and after human SARS-CoV-2 infection.\n\nDuring acute COVID-19, we observed an increase in germinal centre activity, a substantial expansion of antibody-secreting cells and the generation of SARS-CoV-2-neutralising antibodies. Despite gradually decreasing antibody levels, we show persistent, neutralising antibody titres as well as robust specific memory B cell responses and polyfunctional T cell responses at 5 and 9 months after symptom onset in both moderate and severe COVID-19 patients.\n\nOur findings describe the initiation and, importantly, persistence of cellular and humoral SARS-CoV-2-specific immunological memory in hospitalised COVID-19 patients long after recovery, likely contributing towards protection against reinfection.", "doi": "10.1002/cti2.1306", "pmid": "34257967", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null, "Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pmc", "key": "PMC8256672"}, {"db": "pii", "key": "CTI21306"}], "notes": [], "created": "2021-08-06T07:28:49.240Z", "modified": "2023-06-19T14:32:39.642Z"}, {"entity": "publication", "iuid": "a8a1f08519534f2b9ad1e1c26c3c0bd6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8a1f08519534f2b9ad1e1c26c3c0bd6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8a1f08519534f2b9ad1e1c26c3c0bd6"}}, "title": "Randomised, controlled, open label, multicentre clinical trial to explore safety and efficacy of hyperbaric oxygen for preventing ICU admission, morbidity and mortality in adult patients with COVID-19.", "authors": [{"family": "Kjellberg", "given": "Anders", "initials": "A", "orcid": "0000-0002-4819-1024", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81941232265d46679c08c40c068e91c4.json"}}, {"family": "Douglas", "given": "Johan", "initials": "J"}, {"family": "Pawlik", "given": "Michael T", "initials": "MT"}, {"family": "Kraus", "given": "Michael", "initials": "M"}, {"family": "Oscarsson", "given": "Nicklas", "initials": "N", "orcid": "0000-0002-0460-1829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1cbe3fa1d184960b75b8c4d9f3815a5.json"}}, {"family": "Zheng", "given": "Xiaowei", "initials": "X", "orcid": "0000-0002-2648-1119", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11b4ff5b9cea4b20afef48998931a75d.json"}}, {"family": "Bergman", "given": "Peter", "initials": "P", "orcid": "0000-0003-3306-3713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15b7290255814a7b9a1a97c3cdb2fc26.json"}}, {"family": "Fr\u00e5nberg", "given": "Oskar", "initials": "O", "orcid": "0000-0001-7051-3256", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7cdc60d7c4cb4bd7973fb282761e6191.json"}}, {"family": "Kowalski", "given": "Jan H", "initials": "JH"}, {"family": "Nyren", "given": "Sven Paul", "initials": "SP"}, {"family": "Silvanius", "given": "M\u00e5rten", "initials": "M", "orcid": "0000-0002-4629-6324", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45f5315fd0084d31a810787a8768cfc2.json"}}, {"family": "Skold", "given": "Magnus", "initials": "M"}, {"family": "Catrina", "given": "Sergiu-Bogdan", "initials": "SB", "orcid": "0000-0002-6914-3902", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/855bdd67b10940528effc10f51b92e17.json"}}, {"family": "Rodriguez-Wallberg", "given": "Kenny A", "initials": "KA", "orcid": "0000-0003-4378-6181", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d45aa8a66f64858b4f9be050046e8a2.json"}}, {"family": "Lindholm", "given": "Peter", "initials": "P", "orcid": "0000-0002-0840-9244", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e98ca6dca1542a3acbd5a0516f0254d.json"}}], "type": "journal article", "published": "2021-07-05", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "7", "pages": "e046738", "issn-l": "2044-6055"}, "abstract": "COVID-19 may cause severe pneumonitis and trigger a massive inflammatory response that requires ventilatory support. The intensive care unit (ICU)-mortality has been reported to be as high as 62%. Dexamethasone is the only of all anti-inflammatory drugs that have been tested to date that has shown a positive effect on mortality. We aim to explore if treatment with hyperbaric oxygen (HBO) is safe and effective for patients with severe COVID-19. Our hypothesis is that HBO can prevent ICU admission, morbidity and mortality by attenuating the inflammatory response. The primary objective is to evaluate if HBO reduces the number of ICU admissions compared with best practice treatment for COVID-19, main secondary objectives are to evaluate if HBO reduces the load on ICU resources, morbidity and mortality and to evaluate if HBO mitigates the inflammatory reaction in COVID-19.\n\nA randomised, controlled, phase II, open label, multicentre trial. 200 subjects with severe COVID-19 and at least two risk factors for mortality will be included. Baseline clinical data and blood samples will be collected before randomisation and repeated daily for 7 days, at days 14 and 30. Subjects will be randomised with a computer-based system to HBO, maximum five times during the first 7 days plus best practice treatment or only best practice treatment. The primary endpoint, ICU admission, is defined by criteria for selection for ICU. We will evaluate if HBO mitigates the inflammatory reaction in COVID-19 using molecular analyses. All parameters are recorded in an electronic case report form. An independent Data Safety Monitoring Board will review the safety parameters.\n\nThe trial is approved by The National Institutional Review Board in Sweden (2020-01705) and the Swedish Medical Product Agency (5.1-2020-36673). Positive, negative and any inconclusive results will be published in peer-reviewed scientific journals with open access.\n\nNCT04327505. EudraCT number: 2020-001349-37.", "doi": "10.1136/bmjopen-2020-046738", "pmid": "34226219", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-046738"}, {"db": "pmc", "key": "PMC8260306"}, {"db": "ClinicalTrials.gov", "key": "NCT04327505"}, {"db": "EudraCT", "key": "2020-001349-37"}], "notes": [], "created": "2021-08-06T08:44:46.219Z", "modified": "2021-08-06T08:44:46.421Z"}, {"entity": "publication", "iuid": "bb3af7105efd4b57a5877b70928dfa57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb3af7105efd4b57a5877b70928dfa57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb3af7105efd4b57a5877b70928dfa57"}}, "title": "Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1.", "authors": [{"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Orlova", "given": "Elizaveta", "initials": "E"}, {"family": "Sozaeva", "given": "Leila", "initials": "L"}, {"family": "L\u00e9vy", "given": "Romain", "initials": "R"}, {"family": "James", "given": "Alyssa", "initials": "A"}, {"family": "Schmitt", "given": "Monica M", "initials": "MM"}, {"family": "Ochoa", "given": "Sebastian", "initials": "S"}, {"family": "Kareva", "given": "Maria", "initials": "M"}, {"family": "Rodina", "given": "Yulia", "initials": "Y"}, {"family": "Gervais", "given": "Adrian", "initials": "A"}, {"family": "Le Voyer", "given": "Tom", "initials": "T"}, {"family": "Rosain", "given": "J\u00e9r\u00e9mie", "initials": "J"}, {"family": "Philippot", "given": "Quentin", "initials": "Q"}, {"family": "Neehus", "given": "Anna-Lena", "initials": "AL"}, {"family": "Shaw", "given": "Elana", "initials": "E"}, {"family": "Migaud", "given": "M\u00e9lanie", "initials": "M"}, {"family": "Bizien", "given": "Lucy", "initials": "L"}, {"family": "Ekwall", "given": "Olov", "initials": "O"}, {"family": "Berg", "given": "Stefan", "initials": "S"}, {"family": "Beccuti", "given": "Guglielmo", "initials": "G"}, {"family": "Ghizzoni", "given": "Lucia", "initials": "L"}, {"family": "Thiriez", "given": "G\u00e9rard", "initials": "G"}, {"family": "Pavot", "given": "Arthur", "initials": "A"}, {"family": "Goujard", "given": "C\u00e9cile", "initials": "C"}, {"family": "Fr\u00e9mond", "given": "Marie-Louise", "initials": "ML"}, {"family": "Carter", "given": "Edwin", "initials": "E"}, {"family": "Rothenbuhler", "given": "Anya", "initials": "A"}, {"family": "Linglart", "given": "Agn\u00e8s", "initials": "A"}, {"family": "Mignot", "given": "Brigite", "initials": "B"}, {"family": "Comte", "given": "Aur\u00e9lie", "initials": "A"}, {"family": "Cheikh", "given": "Nathalie", "initials": "N"}, {"family": "Hermine", "given": "Olivier", "initials": "O"}, {"family": "Breivik", "given": "Lars", "initials": "L"}, {"family": "Husebye", "given": "Eystein S", "initials": "ES"}, {"family": "Humbert", "given": "S\u00e9bastien", "initials": "S"}, {"family": "Rohrlich", "given": "Pierre", "initials": "P"}, {"family": "Coaquette", "given": "Alain", "initials": "A"}, {"family": "Vuoto", "given": "Fanny", "initials": "F"}, {"family": "Faure", "given": "Karine", "initials": "K"}, {"family": "Mahlaoui", "given": "Nizar", "initials": "N"}, {"family": "Kotnik", "given": "Primo\u017e", "initials": "P"}, {"family": "Battelino", "given": "Tadej", "initials": "T"}, {"family": "Trebu\u0161ak Podkraj\u0161ek", "given": "Katarina", "initials": "K"}, {"family": "Kisand", "given": "Kai", "initials": "K"}, {"family": "Ferr\u00e9", "given": "Elise M N", "initials": "EMN"}, {"family": "DiMaggio", "given": "Thomas", "initials": "T"}, {"family": "Rosen", "given": "Lindsey B", "initials": "LB"}, {"family": "Burbelo", "given": "Peter D", "initials": "PD"}, {"family": "McIntyre", "given": "Martin", "initials": "M"}, {"family": "Kann", "given": "Nelli Y", "initials": "NY"}, {"family": "Shcherbina", "given": "Anna", "initials": "A"}, {"family": "Pavlova", "given": "Maria", "initials": "M"}, {"family": "Kolodkina", "given": "Anna", "initials": "A"}, {"family": "Holland", "given": "Steven M", "initials": "SM"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Crow", "given": "Yanick J", "initials": "YJ"}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD"}, {"family": "Su", "given": "Helen C", "initials": "HC"}, {"family": "Abel", "given": "Laurent", "initials": "L"}, {"family": "Anderson", "given": "Mark S", "initials": "MS"}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E"}, {"family": "Neven", "given": "B\u00e9n\u00e9dicte", "initials": "B"}, {"family": "Puel", "given": "Anne", "initials": "A"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL"}, {"family": "Lionakis", "given": "Michail S", "initials": "MS"}], "type": "journal article", "published": "2021-07-05", "journal": {"title": "J Exp Med", "issn": "1540-9538", "volume": "218", "issue": "7", "issn-l": null}, "abstract": "Patients with biallelic loss-of-function variants of AIRE suffer from autoimmune polyendocrine syndrome type-1 (APS-1) and produce a broad range of autoantibodies (auto-Abs), including circulating auto-Abs neutralizing most type I interferons (IFNs). These auto-Abs were recently reported to account for at least 10% of cases of life-threatening COVID-19 pneumonia in the general population. We report 22 APS-1 patients from 21 kindreds in seven countries, aged between 8 and 48 yr and infected with SARS-CoV-2 since February 2020. The 21 patients tested had auto-Abs neutralizing IFN-\u03b1 subtypes and/or IFN-\u03c9; one had anti-IFN-\u03b2 and another anti-IFN-\u03b5, but none had anti-IFN-\u03ba. Strikingly, 19 patients (86%) were hospitalized for COVID-19 pneumonia, including 15 (68%) admitted to an intensive care unit, 11 (50%) who required mechanical ventilation, and four (18%) who died. Ambulatory disease in three patients (14%) was possibly accounted for by prior or early specific interventions. Preexisting auto-Abs neutralizing type I IFNs in APS-1 patients confer a very high risk of life-threatening COVID-19 pneumonia at any age.", "doi": "10.1084/jem.20210554", "pmid": "33890986", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Proteins": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "212019"}], "notes": [], "created": "2021-04-29T15:37:10.750Z", "modified": "2021-04-29T15:37:10.760Z"}, {"entity": "publication", "iuid": "3dcd82f3a4c5470d8cca7f78ab45bf73", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3dcd82f3a4c5470d8cca7f78ab45bf73.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3dcd82f3a4c5470d8cca7f78ab45bf73"}}, "title": "Fitness, strength and severity of COVID-19: a prospective register study of 1 559 187 Swedish conscripts.", "authors": [{"family": "Af Geijerstam", "given": "Agnes", "initials": "A", "orcid": "0000-0002-0897-6548", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ab4ce35a27d446da006cd3aece117c2.json"}}, {"family": "Mehlig", "given": "Kirsten", "initials": "K"}, {"family": "B\u00f6rjesson", "given": "Mats", "initials": "M"}, {"family": "Robertson", "given": "Josefina", "initials": "J"}, {"family": "Nyberg", "given": "Jenny", "initials": "J", "orcid": "0000-0002-4336-3886", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b78a1fdee10c49c8b1adc25be46e4e81.json"}}, {"family": "Adiels", "given": "Martin", "initials": "M"}, {"family": "Rosengren", "given": "Annika", "initials": "A"}, {"family": "\u00c5berg", "given": "Maria", "initials": "M"}, {"family": "Lissner", "given": "Lauren", "initials": "L"}], "type": "journal article", "published": "2021-07-05", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "7", "pages": "e051316"}, "abstract": "To investigate the possible connection between cardiorespiratory fitness (CRF) and muscle strength in early adulthood and severity of COVID-19 later in life.\r\n\r\nProspective registry-based cohort study.\r\n\r\n1 559 187 Swedish men, undergoing military conscription between 1968 and 2005 at a mean age of 18.3 (SD 0.73) years.\r\n\r\nHospitalisation, intensive care or death due to COVID-19 from March to September 2020, in relation to CRF and muscle strength.\r\n\r\nHigh CRF in late adolescence and early adulthood had a protective association with severe COVID-19 later in life with OR (95% CI) 0.76 (0.67 to 0.85) for hospitalisation (n=2 006), 0.61 (0.48 to 0.78) for intensive care (n=445) and 0.56 (0.37 to 0.85) for mortality (n=149), compared with the lowest category of CRF. The association remains unchanged when controlled for body mass index (BMI), blood pressure, chronic diseases and parental education level at baseline, and incident cardiovascular disease before 2020. Moreover, lower muscle strength in late adolescence showed a linear association with a higher risk of all three outcomes when controlled for BMI and height.\r\n\r\nPhysical fitness at a young age is associated with severity of COVID-19 many years later. This underscores the necessity to increase the general physical fitness of the population to offer protection against future viral pandemics.", "doi": "10.1136/bmjopen-2021-051316", "pmid": "34226237", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-051316"}, {"db": "pmc", "key": "PMC8260308"}], "notes": [], "created": "2021-08-06T08:42:38.882Z", "modified": "2021-11-18T08:21:04.348Z"}, {"entity": "publication", "iuid": "db38442d89774784b668ca7f58909833", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db38442d89774784b668ca7f58909833.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db38442d89774784b668ca7f58909833"}}, "title": "Site-Specific Steric Control of SARS-CoV-2 Spike Glycosylation.", "authors": [{"family": "Allen", "given": "Joel D", "initials": "JD", "orcid": "0000-0003-2547-968X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/81deac3f18124364945b49be654210ed.json"}}, {"family": "Chawla", "given": "Himanshi", "initials": "H", "orcid": "0000-0001-9828-6593", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/882a202ebc104941984b1a642ed2dbe1.json"}}, {"family": "Samsudin", "given": "Firdaus", "initials": "F"}, {"family": "Zuzic", "given": "Lorena", "initials": "L", "orcid": "0000-0002-7834-612X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18d2dac8ab53482ebd2d5d5ba0b5d658.json"}}, {"family": "Shivgan", "given": "Aishwary Tukaram", "initials": "AT", "orcid": "0000-0002-2032-8738", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aaab454de9af4638b44f42b80121e2cc.json"}}, {"family": "Watanabe", "given": "Yasunori", "initials": "Y", "orcid": "0000-0002-7952-1268", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bcf2603906ff489dae169ea389b7a26a.json"}}, {"family": "He", "given": "Wan-Ting", "initials": "WT"}, {"family": "Callaghan", "given": "Sean", "initials": "S"}, {"family": "Song", "given": "Ge", "initials": "G"}, {"family": "Yong", "given": "Peter", "initials": "P", "orcid": "0000-0002-4899-3270", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ec57ed902be4604a6009335eeac6e92.json"}}, {"family": "Brouwer", "given": "Philip J M", "initials": "PJM"}, {"family": "Song", "given": "Yutong", "initials": "Y", "orcid": "0000-0002-2206-9549", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56c58af22e0d432cb6cfca65fc4feafb.json"}}, {"family": "Cai", "given": "Yongfei", "initials": "Y"}, {"family": "Duyvesteyn", "given": "Helen M E", "initials": "HME"}, {"family": "Malinauskas", "given": "Tomas", "initials": "T", "orcid": "0000-0002-4847-5529", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a331fc8e9eb434aadcc98f434a1e867.json"}}, {"family": "Kint", "given": "Joeri", "initials": "J"}, {"family": "Pino", "given": "Paco", "initials": "P"}, {"family": "Wurm", "given": "Maria J", "initials": "MJ"}, {"family": "Frank", "given": "Martin", "initials": "M", "orcid": "0000-0002-1006-6746", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee6b5d165615455da3cf49fad65598e9.json"}}, {"family": "Chen", "given": "Bing", "initials": "B"}, {"family": "Stuart", "given": "David I", "initials": "DI", "orcid": "0000-0002-3426-4210", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c24b849d3d54c2c9c7b0b68faed3d5a.json"}}, {"family": "Sanders", "given": "Rogier W", "initials": "RW"}, {"family": "Andrabi", "given": "Raiees", "initials": "R"}, {"family": "Burton", "given": "Dennis R", "initials": "DR"}, {"family": "Li", "given": "Sai", "initials": "S", "orcid": "0000-0002-9353-0355", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56db840c41a54d52876c2ac1c8e5ec35.json"}}, {"family": "Bond", "given": "Peter J", "initials": "PJ", "orcid": "0000-0003-2900-098X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5bac218641b4642a498eafe60eafcf5.json"}}, {"family": "Crispin", "given": "Max", "initials": "M", "orcid": "0000-0002-1072-2694", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4341966010144757aa3af354e579c713.json"}}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "Biochemistry", "issn": "1520-4995", "issn-l": null}, "abstract": "A central tenet in the design of vaccines is the display of native-like antigens in the elicitation of protective immunity. The abundance of N-linked glycans across the SARS-CoV-2 spike protein is a potential source of heterogeneity among the many different vaccine candidates under investigation. Here, we investigate the glycosylation of recombinant SARS-CoV-2 spike proteins from five different laboratories and compare them against S protein from infectious virus, cultured in Vero cells. We find patterns that are conserved across all samples, and this can be associated with site-specific stalling of glycan maturation that acts as a highly sensitive reporter of protein structure. Molecular dynamics simulations of a fully glycosylated spike support a model of steric restrictions that shape enzymatic processing of the glycans. These results suggest that recombinant spike-based SARS-CoV-2 immunogen glycosylation reproducibly recapitulates signatures of viral glycosylation.", "doi": "10.1021/acs.biochem.1c00279", "pmid": "34213308", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-07-05T14:59:39.053Z", "modified": "2021-07-05T14:59:39.310Z"}, {"entity": "publication", "iuid": "4272a6d8972e4112944a7ff85e4a5385", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4272a6d8972e4112944a7ff85e4a5385.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4272a6d8972e4112944a7ff85e4a5385"}}, "title": "Perceived changes in capability during the COVID-19 pandemic: A Swedish cross-sectional study from June 2020.", "authors": [{"family": "Meili", "given": "Kaspar Walter", "initials": "KW"}, {"family": "Jonsson", "given": "H\u00e5kan", "initials": "H"}, {"family": "Lindholm", "given": "Lars", "initials": "L"}, {"family": "M\u00e5nsdotter", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": null, "issue": null, "pages": "14034948211023633"}, "abstract": "Measures against COVID-19 potentially impact quality of life in different ways. The capability approach by Amartya Sen with a broad and consistent framework for measuring quality of life is suited to capture the various consequences. We aimed to examine (a) whether individuals experienced change in 10 capability dimensions during the first half of 2020, (b) which dimensions were affected most, and (c) whether changes were unequally distributed in terms of gender, education, income, geography, housing, living situation and place of birth.\r\n\r\nWe assessed self-reported capability change in Sweden in 10 capability dimensions in a cross-sectional online survey among 500 participants on a five-item Likert scale. We analysed the distribution of answers by comparing the balance of positive and negative perceived changes and used mixed effects logistic regression to examine associations with background characteristics of the participants.\r\n\r\nReported perceived negative changes outweighed positive changes, and a higher proportion stated negative perceived changes if they also stated having low capability in the same dimension. In the capabilities of financial situation, political resources and health, the proportions of perceived negative change were highest. Odds for perceived negative change compared to no or positive change were higher for higher incomes, living in medium-sized municipalities, being born outside Europe, living in the south of Sweden, and renting instead of owning housing.\r\n\r\nSelf-reported negative capability change, and associated inequalities related to socioeconomic position, place of birth and regional residence should be of concern for policymakers.", "doi": "10.1177/14034948211023633", "pmid": "34213363", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "URL", "key": "https://snd.gu.se/sv/catalogue/study/2020-206/1/1#dataset", "description": "Dataset: capability change covid-19"}], "notes": [], "created": "2021-07-05T15:00:45.933Z", "modified": "2021-07-14T11:52:21.660Z"}, {"entity": "publication", "iuid": "d5f7250bfeb6416cb1876c988606d4d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5f7250bfeb6416cb1876c988606d4d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5f7250bfeb6416cb1876c988606d4d4"}}, "title": "Mobility restrictions were associated with reductions in COVID-19 incidence early in the pandemic: evidence from a real-time evaluation in 34 countries.", "authors": [{"family": "Oh", "given": "Juhwan", "initials": "J"}, {"family": "Lee", "given": "Hwa-Young", "initials": "HY"}, {"family": "Khuong", "given": "Quynh Long", "initials": "QL"}, {"family": "Markuns", "given": "Jeffrey F", "initials": "JF"}, {"family": "Bullen", "given": "Chris", "initials": "C"}, {"family": "Barrios", "given": "Osvaldo Enrique Artaza", "initials": "OEA"}, {"family": "Hwang", "given": "Seung-Sik", "initials": "SS"}, {"family": "Suh", "given": "Young Sahng", "initials": "YS"}, {"family": "McCool", "given": "Judith", "initials": "J"}, {"family": "Kachur", "given": "S Patrick", "initials": "SP"}, {"family": "Chan", "given": "Chang-Chuan", "initials": "CC"}, {"family": "Kwon", "given": "Soonman", "initials": "S"}, {"family": "Kondo", "given": "Naoki", "initials": "N"}, {"family": "Hoang", "given": "Van Minh", "initials": "VM"}, {"family": "Moon", "given": "J Robin", "initials": "JR"}, {"family": "Rostila", "given": "Mikael", "initials": "M"}, {"family": "Norheim", "given": "Ole F", "initials": "OF"}, {"family": "You", "given": "Myoungsoon", "initials": "M"}, {"family": "Withers", "given": "Mellissa", "initials": "M"}, {"family": "Li", "given": "Mu", "initials": "M"}, {"family": "Lee", "given": "Eun-Jeung", "initials": "EJ"}, {"family": "Benski", "given": "Caroline", "initials": "C"}, {"family": "Park", "given": "Sookyung", "initials": "S"}, {"family": "Nam", "given": "Eun-Woo", "initials": "EW"}, {"family": "Gottschalk", "given": "Katie", "initials": "K"}, {"family": "Kavanagh", "given": "Matthew M", "initials": "MM"}, {"family": "Tran", "given": "Thi Giang Huong", "initials": "TGH"}, {"family": "Lee", "given": "Jong-Koo", "initials": "JK"}, {"family": "Subramanian", "given": "S V", "initials": "SV"}, {"family": "McKee", "given": "Martin", "initials": "M"}, {"family": "Gostin", "given": "Lawrence O", "initials": "LO"}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "13717", "issn-l": "2045-2322"}, "abstract": "Most countries have implemented restrictions on mobility to prevent the spread of Coronavirus disease-19 (COVID-19), entailing considerable societal costs but, at least initially, based on limited evidence of effectiveness. We asked whether mobility restrictions were associated with changes in the occurrence of COVID-19 in 34 OECD countries plus Singapore and Taiwan. Our data sources were the Google Global Mobility Data Source, which reports different types of mobility, and COVID-19 cases retrieved from the dataset curated by Our World in Data. Beginning at each country's 100th case, and incorporating a 14-day lag to account for the delay between exposure and illness, we examined the association between changes in mobility (with January 3 to February 6, 2020 as baseline) and the ratio of the number of newly confirmed cases on a given day to the total number of cases over the past 14 days from the index day (the potentially infective 'pool' in that population), per million population, using LOESS regression and logit regression. In two-thirds of examined countries, reductions of up to 40% in commuting mobility (to workplaces, transit stations, retailers, and recreation) were associated with decreased cases, especially early in the pandemic. Once both mobility and incidence had been brought down, further restrictions provided little additional benefit. These findings point to the importance of acting early and decisively in a pandemic.", "doi": "10.1038/s41598-021-92766-z", "pmid": "34215764", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-92766-z"}], "notes": [], "created": "2021-07-05T15:01:41.748Z", "modified": "2021-07-05T15:01:41.761Z"}, {"entity": "publication", "iuid": "5b593319005f4e1aa7583b3cadcdced8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5b593319005f4e1aa7583b3cadcdced8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5b593319005f4e1aa7583b3cadcdced8"}}, "title": "Increased rate of hospitalisation for COVID-19 among rituximab-treated multiple sclerosis patients: A study of the Swedish multiple sclerosis registry.", "authors": [{"family": "Spelman", "given": "Tim", "initials": "T", "orcid": "0000-0001-9204-3216", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab24deed7243491387cb220c2a0c8606.json"}}, {"family": "Forsberg", "given": "Lars", "initials": "L"}, {"family": "McKay", "given": "Kyla", "initials": "K"}, {"family": "Glaser", "given": "Anna", "initials": "A"}, {"family": "Hillert", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "Mult Scler", "issn": "1477-0970", "pages": "13524585211026272", "issn-l": null}, "abstract": "The primary objective of this study was to analyse the association between multiple sclerosis (MS) disease-modifying therapy (DMT) exposure and hospitalisation in patients infected with COVID-19.\n\nAssociations between MS DMT exposure and COVID-19 hospitalisation were analysed using univariable and multi-variable-clustered propensity score weighted logistic regression, where the models were clustered on the individual patients to control for patients contributing multiple COVID-19 episodes.\n\nAs of 18 January 2021, a total of 476 reported COVID-19 cases had been recorded in MS patients in the Swedish MS registry. Of these, 292 (61.3%) had confirmed COVID-19. The mean value (standard deviation (SD)) age at infection was 44.0 years (11.6). Of the 292 confirmed infections, 68 (23.2%) required hospitalisation. A total of 49 of the 164 confirmed COVID-19 patients on rituximab at baseline (29.9%) required hospitalisation, compared to a rate of 12.7% for all other DMTs combined. Rituximab in confirmed COVID-19 patients was associated with 2.95 times the odds of hospitalisation relative to any other DMT combined (odds ratio = 2.95; 95% confidence interval (CI) = 1.48-5.87).\n\nRituximab treatment, known to increase the risk of severe infections in general, also confers such a risk for MS patients with COVID-19, in comparison with other MS DMTs.", "doi": "10.1177/13524585211026272", "pmid": "34212816", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-07-05T14:58:20.082Z", "modified": "2021-07-05T14:58:20.119Z"}, {"entity": "publication", "iuid": "be233521a08a4dd8a582810f62e9423d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be233521a08a4dd8a582810f62e9423d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be233521a08a4dd8a582810f62e9423d"}}, "title": "High Amounts of SARS-CoV-2 Precede Sickness Among Asymptomatic Health Care Workers.", "authors": [{"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Elfstr\u00f6m", "given": "K Miriam", "initials": "KM"}, {"family": "Blomqvist", "given": "Jonas", "initials": "J"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M"}, {"family": "Eklund", "given": "Carina", "initials": "C"}, {"family": "Boulund", "given": "Fredrik", "initials": "F"}, {"family": "Lagheden", "given": "Camilla", "initials": "C"}, {"family": "Hamsten", "given": "Marica", "initials": "M"}, {"family": "Nordqvist-Kleppe", "given": "Sara", "initials": "S"}, {"family": "Seifert", "given": "Maike", "initials": "M"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Olofsson", "given": "Jennie", "initials": "J"}, {"family": "Andersson", "given": "Eni", "initials": "E"}, {"family": "Falk", "given": "August Jernbom", "initials": "AJ"}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S"}, {"family": "Hultin", "given": "Emilie", "initials": "E"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Pimenoff", "given": "Ville N", "initials": "VN"}, {"family": "Hassan", "given": "Sadaf", "initials": "S"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Mattsson", "given": "Johan", "initials": "J"}, {"family": "Arroyo M\u00fchr", "given": "Laila Sara", "initials": "LS"}, {"family": "Lundgren", "given": "Kalle Conneryd", "initials": "KC"}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899", "volume": "224", "issue": "1", "pages": "14-20"}, "abstract": "Whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positivity among asymptomatic subjects reflects past or future disease may be difficult to ascertain.\n\nWe tested 9449 employees at Karolinska University Hospital, Stockholm, Sweden for SARS-CoV-2 RNA and antibodies, linked the results to sick leave records, and determined associations with past or future sick leave using multinomial logistic regression.\n\nSubjects with high amounts of SARS-CoV-2 virus, indicated by polymerase chain reaction (PCR) cycle threshold (Ct) value, had the highest risk for sick leave in the 2 weeks after testing (odds ratio [OR], 11.97; 95% confidence interval [CI], 6.29-22.80) whereas subjects with low amounts of virus had the highest risk for sick leave in the 3 weeks before testing (OR, 6.31; 95% CI, 4.38-9.08). Only 2.5% of employees were SARS-CoV-2 positive while 10.5% were positive by serology and 1.2% were positive in both tests. Serology-positive subjects were not at excess risk for future sick leave (OR, 1.06; 95% CI, .71-1.57).\n\nHigh amounts of SARS-CoV-2 virus, as determined using PCR Ct values, was associated with development of sickness in the next few weeks. Results support the concept that PCR Ct may be informative when testing for SARS-CoV-2. Clinical Trials Registration. NCT04411576.", "doi": "10.1093/infdis/jiab099", "pmid": "33580261", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Research Area: High-throughput and high-content serology": null}, "xrefs": [{"db": "pmc", "key": "PMC7928785"}, {"db": "pii", "key": "6134453"}, {"db": "ClinicalTrials.gov", "key": "NCT04411576"}], "notes": [], "created": "2021-02-15T12:44:13.720Z", "modified": "2023-06-19T14:23:42.228Z"}, {"entity": "publication", "iuid": "b819f37c7eef4cc6b647ccab35dd3af4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b819f37c7eef4cc6b647ccab35dd3af4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b819f37c7eef4cc6b647ccab35dd3af4"}}, "title": "Frequency of Thrombocytopenia and Platelet Factor 4/Heparin Antibodies in Patients With Cerebral Venous Sinus Thrombosis Prior to the COVID-19 Pandemic.", "authors": [{"family": "S\u00e1nchez van Kammen", "given": "Mayte", "initials": "M"}, {"family": "Heldner", "given": "Mirjam R", "initials": "MR"}, {"family": "Brodard", "given": "Justine", "initials": "J"}, {"family": "Scutelnic", "given": "Adrian", "initials": "A"}, {"family": "Silvis", "given": "Suzanne", "initials": "S"}, {"family": "Schroeder", "given": "Verena", "initials": "V"}, {"family": "Kremer Hovinga", "given": "Johanna A", "initials": "JA"}, {"family": "Middeldorp", "given": "Saskia", "initials": "S"}, {"family": "Levi", "given": "Marcel", "initials": "M"}, {"family": "Hiltunen", "given": "Sini", "initials": "S"}, {"family": "Lindgren", "given": "Erik", "initials": "E"}, {"family": "Mansour", "given": "Maryam", "initials": "M"}, {"family": "Arauz", "given": "Antonio", "initials": "A"}, {"family": "Barboza", "given": "Miguel A", "initials": "MA"}, {"family": "Zuurbier", "given": "Susanna M", "initials": "SM"}, {"family": "Aguiar de Sousa", "given": "Diana", "initials": "D"}, {"family": "Ferro", "given": "Jose M", "initials": "JM"}, {"family": "Fischer", "given": "Urs", "initials": "U"}, {"family": "Field", "given": "Thalia S", "initials": "TS"}, {"family": "Jood", "given": "Katarina", "initials": "K"}, {"family": "Tatlisumak", "given": "Turgut", "initials": "T"}, {"family": "Putaala", "given": "Jukka", "initials": "J"}, {"family": "Arnold", "given": "Marcel", "initials": "M"}, {"family": "Coutinho", "given": "Jonathan M", "initials": "JM"}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484"}, "abstract": "Cases of cerebral venous sinus thrombosis in combination with thrombocytopenia have recently been reported within 4 to 28 days of vaccination with the ChAdOx1 nCov-19 (AstraZeneca/Oxford) and Ad.26.COV2.S (Janssen/Johnson & Johnson) COVID-19 vaccines. An immune-mediated response associated with platelet factor 4/heparin antibodies has been proposed as the underlying pathomechanism.\n\nTo determine the frequencies of admission thrombocytopenia, heparin-induced thrombocytopenia, and presence of platelet factor 4/heparin antibodies in patients diagnosed with cerebral venous sinus thrombosis prior to the COVID-19 pandemic.\n\nThis was a descriptive analysis of a retrospective sample of consecutive patients diagnosed with cerebral venous sinus thrombosis between January 1987 and March 2018 from 7 hospitals participating in the International Cerebral Venous Sinus Thrombosis Consortium from Finland, the Netherlands, Switzerland, Sweden, Mexico, Iran, and Costa Rica. Of 952 patients, 865 with available baseline platelet count were included. In a subset of 93 patients, frozen plasma samples collected during a previous study between September 2009 and February 2016 were analyzed for the presence of platelet factor 4/heparin antibodies.\n\nDiagnosis of cerebral venous sinus thrombosis.\n\nFrequencies of admission thrombocytopenia (platelet count <150 \u00d7103/\u03bcL), heparin-induced thrombocytopenia (as diagnosed by the treating physician), and platelet factor 4/heparin IgG antibodies (optical density >0.4, in a subset of patients with previously collected plasma samples).\n\nOf 865 patients (median age, 40 years [interquartile range, 29-53 years], 70% women), 73 (8.4%; 95% CI, 6.8%-10.5%) had thrombocytopenia, which was mild (100-149 \u00d7103/\u03bcL) in 52 (6.0%), moderate (50-99 \u00d7103/\u03bcL) in 17 (2.0%), and severe (<50 \u00d7103/\u03bcL) in 4 (0.5%). Heparin-induced thrombocytopenia with platelet factor 4/heparin antibodies was diagnosed in a single patient (0.1%; 95% CI, <0.1%-0.7%). Of the convenience sample of 93 patients with cerebral venous sinus thrombosis included in the laboratory analysis, 8 (9%) had thrombocytopenia, and none (95% CI, 0%-4%) had platelet factor 4/heparin antibodies.\n\nIn patients with cerebral venous sinus thrombosis prior to the COVID-19 pandemic, baseline thrombocytopenia was uncommon, and heparin-induced thrombocytopenia and platelet factor 4/heparin antibodies were rare. These findings may inform investigations of the possible association between the ChAdOx1 nCoV-19 and Ad26.COV2.S COVID-19 vaccines and cerebral venous sinus thrombosis with thrombocytopenia.", "doi": "10.1001/jama.2021.9889", "pmid": "34213527", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "2781791"}], "notes": [], "created": "2021-07-05T15:01:14.308Z", "modified": "2021-07-05T15:01:14.319Z"}, {"entity": "publication", "iuid": "510aa8ca7cef4ebdbb950f0fb539bc28", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/510aa8ca7cef4ebdbb950f0fb539bc28.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/510aa8ca7cef4ebdbb950f0fb539bc28"}}, "title": "Factors preventing SARS-CoV-2 transmission during unintentional exposure in a GP practice: a cohort study of patient contacts; Germany, 2020.", "authors": [{"family": "Boender", "given": "T Sonia", "initials": "TS", "orcid": "0000-0002-4418-3713", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0d75319e2f6428c8319ffeca3f52128.json"}}, {"family": "Bender", "given": "Jennifer K", "initials": "JK", "orcid": "0000-0001-5167-3836", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87d9bb9464334375911956504495bf54.json"}}, {"family": "Kr\u00fcger", "given": "Angelika", "initials": "A"}, {"family": "Michaelis", "given": "Kai", "initials": "K"}, {"family": "Buchholz", "given": "Udo", "initials": "U", "orcid": "0000-0001-6597-3995", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b447ca62aad648d5bc0fcd5246bf0ba7.json"}}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "pages": "1-17", "issn-l": null}, "abstract": null, "doi": "10.1017/S0950268821001503", "pmid": "34210375", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0950268821001503"}], "notes": [], "created": "2021-07-05T14:58:02.461Z", "modified": "2021-07-05T14:58:02.553Z"}, {"entity": "publication", "iuid": "0b39ec84783a4dff9c46a86c6c3e6882", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b39ec84783a4dff9c46a86c6c3e6882.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b39ec84783a4dff9c46a86c6c3e6882"}}, "title": "COVID-19 and the Digitalisation of Cardiovascular Training and Education-A Review of Guiding Themes for Equitable and Effective Post-graduate Telelearning.", "authors": [{"family": "Chong", "given": "Jun Hua", "initials": "JH"}, {"family": "Chahal", "given": "C Anwar A", "initials": "CAA"}, {"family": "Gupta", "given": "Ajay", "initials": "A"}, {"family": "Ricci", "given": "Fabrizio", "initials": "F"}, {"family": "Westwood", "given": "Mark", "initials": "M"}, {"family": "Pugliese", "given": "Francesca", "initials": "F"}, {"family": "Petersen", "given": "Steffen E", "initials": "SE"}, {"family": "Khanji", "given": "Mohammed Y", "initials": "MY"}], "type": "journal article", "published": "2021-07-02", "journal": {"title": "Front Cardiovasc Med", "issn": "2297-055X", "volume": "8", "pages": "666119", "issn-l": null}, "abstract": "The coronavirus disease-2019 (COVID-19) pandemic has had an unprecedented impact leading to novel adaptations in post-graduate medical education for cardiovascular and general internal medicine. Whilst the results of initial community COVID-19 vaccination are awaited, continuation of multimodality teaching and training that incorporates telelearning will have enduring benefit to post-graduate education and will place educational establishments in good stead to nimbly respond in future pandemic-related public health emergencies. With the rise in innovative virtual learning solutions, medical educators will have to leverage technology to develop electronic educational materials and virtual courses that facilitate adult learning. Technology-enabled virtual learning is thus a timely progression of hybrid classroom initiatives that are already adopted to varying degrees, with a need for faculty to serve as subject matter experts, to host and moderate online discussions, and to provide feedback and overall mentorship. As an extension from existing efforts, simulation-based teaching (SBT) and learning and the use of mixed reality technology should also form a greater core in the cardiovascular medicine curriculum. We highlight five foundational themes for building a successful e-learning model in cardiovascular and general post-graduate medical training: (1) digital solutions and associated infrastructure; (2) equity in access; (3) participant engagement; (4) diversity and inclusion; and (5) patient confidentiality and governance framework. With digitalisation impacting our everyday lives and now how we teach and train in medicine, these five guiding principles provide a cognitive scaffold for careful consideration of the required ecosystem in which cardiovascular and general post-graduate medical education can effectively operate. With due consideration of various e-learning options and associated infrastructure needs; and adoption of strategies for participant engagement under sound and just governance, virtual training in medicine can be effective, inclusive and equitable through the COVID-19 era and beyond.", "doi": "10.3389/fcvm.2021.666119", "pmid": "34277728", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8283504"}], "notes": [], "created": "2021-08-05T11:13:06.304Z", "modified": "2021-08-05T11:13:06.327Z"}, {"entity": "publication", "iuid": "43b7e6f8efe34106853a4b413cf18a47", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/43b7e6f8efe34106853a4b413cf18a47.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/43b7e6f8efe34106853a4b413cf18a47"}}, "title": "Symptoms, symptom relief and support in COVID-19 patients dying in hospitals during the first pandemic wave.", "authors": [{"family": "Martinsson", "given": "Lisa", "initials": "L", "orcid": "0000-0003-4126-2675", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e4341a69741544f5a98afc9620b7a698.json"}}, {"family": "Bergstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Hedman", "given": "Christel", "initials": "C"}, {"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "Lundstr\u00f6m", "given": "Staffan", "initials": "S"}], "type": "journal article", "published": "2021-07-01", "journal": {"title": "BMC Palliat Care", "issn": "1472-684X", "volume": "20", "issue": "1", "pages": "102", "issn-l": null}, "abstract": "At the time of the first wave of the COVID-19 pandemic in Sweden, little was known about how effective our regular end-of-life care strategies would be for patients dying from COVID-19 in hospitals. The aim of the study was to describe and evaluate end-of-life care for patients dying from COVID-19 in hospitals in Sweden up until up until 12 November 2020.\n\nData were collected from the Swedish Register of Palliative Care. Hospital deaths during 2020 for patients with COVID-19 were included and compared to a reference cohort of hospital patients who died during 2019. Logistic regression was used to compare the groups and to control for impact of sex, age and a diagnosis of dementia.\n\nThe COVID-19 group (1476 individuals) had a lower proportion of women and was older compared to the reference cohort (13,158 individuals), 81.8 versus 80.6 years (p < .001). Breathlessness was more commonly reported in the COVID-19 group compared to the reference cohort (72% vs 43%, p < .001). Furthermore, anxiety and delirium were more commonly and respiratory secretions, nausea and pain were less commonly reported during the last week in life in the COVID-19 group (p < .001 for all five symptoms). When present, complete relief of anxiety (p = .021), pain (p = .025) and respiratory secretions (p = .037) was more often achieved in the COVID-19 group. In the COVID-19 group, 57% had someone present at the time of death compared to 77% in the reference cohort (p < .001).\n\nThe standard medical strategies for symptom relief and end-of-life care in hospitals seemed to be acceptable. Symptoms in COVID-19 deaths in hospitals were relieved as much as or even to a higher degree than in hospitals in 2019. Importantly, though, as a result of closing the hospitals to relatives and visitors, patients dying from COVID-19 more frequently died alone, and healthcare providers were not able to substitute for absent relatives.", "doi": "10.1186/s12904-021-00785-4", "pmid": "34210312", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12904-021-00785-4"}], "notes": [], "created": "2021-07-05T14:57:39.411Z", "modified": "2021-07-05T14:57:39.464Z"}, {"entity": "publication", "iuid": "fbe1e98a162b4123b1d6a874566cf6d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fbe1e98a162b4123b1d6a874566cf6d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fbe1e98a162b4123b1d6a874566cf6d0"}}, "title": "Guidance for Health Care Leaders During the Recovery Stage of the COVID-19 Pandemic: A Consensus Statement.", "authors": [{"family": "Geerts", "given": "Jaason M", "initials": "JM"}, {"family": "Kinnair", "given": "Donna", "initials": "D"}, {"family": "Taheri", "given": "Paul", "initials": "P"}, {"family": "Abraham", "given": "Ajit", "initials": "A"}, {"family": "Ahn", "given": "Joonmo", "initials": "J"}, {"family": "Atun", "given": "Rifat", "initials": "R"}, {"family": "Barberia", "given": "Lorena", "initials": "L"}, {"family": "Best", "given": "Nigel J", "initials": "NJ"}, {"family": "Dandona", "given": "Rakhi", "initials": "R"}, {"family": "Dhahri", "given": "Adeel Abbas", "initials": "AA"}, {"family": "Emilsson", "given": "Louise", "initials": "L"}, {"family": "Free", "given": "Julian R", "initials": "JR"}, {"family": "Gardam", "given": "Michael", "initials": "M"}, {"family": "Geerts", "given": "William H", "initials": "WH"}, {"family": "Ihekweazu", "given": "Chikwe", "initials": "C"}, {"family": "Johnson", "given": "Shanthi", "initials": "S"}, {"family": "Kooijman", "given": "Allison", "initials": "A"}, {"family": "Lafontaine", "given": "Alika T", "initials": "AT"}, {"family": "Leshem", "given": "Eyal", "initials": "E"}, {"family": "Lidstone-Jones", "given": "Caroline", "initials": "C"}, {"family": "Loh", "given": "Erwin", "initials": "E"}, {"family": "Lyons", "given": "Oscar", "initials": "O"}, {"family": "Neel", "given": "Khalid Ali Fouda", "initials": "KAF"}, {"family": "Nyasulu", "given": "Peter S", "initials": "PS"}, {"family": "Razum", "given": "Oliver", "initials": "O"}, {"family": "Sabourin", "given": "H\u00e9l\u00e8ne", "initials": "H"}, {"family": "Schleifer Taylor", "given": "Jackie", "initials": "J"}, {"family": "Sharifi", "given": "Hamid", "initials": "H"}, {"family": "Stergiopoulos", "given": "Vicky", "initials": "V"}, {"family": "Sutton", "given": "Brett", "initials": "B"}, {"family": "Wu", "given": "Zunyou", "initials": "Z"}, {"family": "Bilodeau", "given": "Marc", "initials": "M"}], "type": "journal article", "published": "2021-07-01", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "volume": "4", "issue": "7", "pages": "e2120295", "issn-l": null}, "abstract": "The COVID-19 pandemic is the greatest global test of health leadership of our generation. There is an urgent need to provide guidance for leaders at all levels during the unprecedented preresolution recovery stage.\n\nTo create an evidence- and expertise-informed framework of leadership imperatives to serve as a resource to guide health and public health leaders during the postemergency stage of the pandemic.\n\nA literature search in PubMed, MEDLINE, and Embase revealed 10 910 articles published between 2000 and 2021 that included the terms leadership and variations of emergency, crisis, disaster, pandemic, COVID-19, or public health. Using the Standards for Quality Improvement Reporting Excellence reporting guideline for consensus statement development, this assessment adopted a 6-round modified Delphi approach involving 32 expert coauthors from 17 countries who participated in creating and validating a framework outlining essential leadership imperatives.\n\nThe 10 imperatives in the framework are: (1) acknowledge staff and celebrate successes; (2) provide support for staff well-being; (3) develop a clear understanding of the current local and global context, along with informed projections; (4) prepare for future emergencies (personnel, resources, protocols, contingency plans, coalitions, and training); (5) reassess priorities explicitly and regularly and provide purpose, meaning, and direction; (6) maximize team, organizational, and system performance and discuss enhancements; (7) manage the backlog of paused services and consider improvements while avoiding burnout and moral distress; (8) sustain learning, innovations, and collaborations, and imagine future possibilities; (9) provide regular communication and engender trust; and (10) in consultation with public health and fellow leaders, provide safety information and recommendations to government, other organizations, staff, and the community to improve equitable and integrated care and emergency preparedness systemwide.\n\nLeaders who most effectively implement these imperatives are ideally positioned to address urgent needs and inequalities in health systems and to cocreate with their organizations a future that best serves stakeholders and communities.", "doi": "10.1001/jamanetworkopen.2021.20295", "pmid": "34236416", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "2781729"}], "notes": [], "created": "2021-08-06T08:00:11.009Z", "modified": "2021-08-06T08:00:11.022Z"}, {"entity": "publication", "iuid": "e636443b37594ed2b682f780ac8e4390", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e636443b37594ed2b682f780ac8e4390.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e636443b37594ed2b682f780ac8e4390"}}, "title": "Fearing fear itself: Crowdsourced longitudinal data on Covid-19-related fear in Sweden.", "authors": [{"family": "Tishelman", "given": "Carol", "initials": "C", "orcid": "0000-0003-4161-0342", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1fbfdb57e5124e72bcffcce93b21fa05.json"}}, {"family": "Hultin-Rosenberg", "given": "Jonas", "initials": "J"}, {"family": "Hadders", "given": "Anna", "initials": "A"}, {"family": "Eriksson", "given": "Lars E", "initials": "LE", "orcid": "0000-0001-5121-5325", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09bec95869bc450aa97e0aa11485807e.json"}}], "type": "journal article", "published": "2021-07-01", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "7", "pages": "e0253371"}, "abstract": "The Covid-19 pandemic has had unprecedented effects on individual lives and livelihoods as well as on social, health, economic and political systems and structures across the world. This article derives from a unique collaboration between researchers and museums using rapid response crowdsourcing to document contemporary life among the general public during the pandemic crisis in Sweden.\r\n\r\nWe use qualitative analysis to explore the narrative crowdsourced submissions of the same 88 individuals at two timepoints, during the 1st and 2nd pandemic waves, about what they most fear in relation to the Covid-19 pandemic, and how their descriptions changed over time. In this self-selected group, we found that aspects they most feared generally concerned responses to the pandemic on a societal level, rather than to the Covid-19 disease itself or other health-related issues. The most salient fears included a broad array of societal issues, including general societal collapse and fears about effects on social and political interactions among people with resulting impact on political order. Notably strong support for the Swedish pandemic response was expressed, despite both national and international criticism.\r\n\r\nThis analysis fills a notable gap in research literature that lacks subjective and detailed investigation of experiences of the general public, despite recognition of the widespread effects of Covid-19 and its' management strategies. Findings address controversy about the role of experts in formulating and communicating strategy, as well as implications of human responses to existential threats. Based on this analysis, we call for broader focus on societal issues related to this existential threat and the responses to it.", "doi": "10.1371/journal.pone.0253371", "pmid": "34197498", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-13032"}], "notes": [], "created": "2021-07-05T14:32:27.688Z", "modified": "2022-11-23T08:55:43.933Z"}, {"entity": "publication", "iuid": "ff2eafd2d1ff48e0a45e97bf05326aa4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff2eafd2d1ff48e0a45e97bf05326aa4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff2eafd2d1ff48e0a45e97bf05326aa4"}}, "title": "Antimicrobial Resistance & Migrants in Sweden: Poor Living Conditions Enforced by Migration Control Policies as a Risk Factor for Optimal Public Health Management.", "authors": [{"family": "Elisabeth", "given": "Mangrio", "initials": "M"}, {"family": "Maneesh", "given": "Paul-Satyaseela", "initials": "PS"}, {"family": "Katarina", "given": "Sj\u00f6gren Forss", "initials": "SF"}, {"family": "Slobodan", "given": "Zdravkovic", "initials": "Z"}, {"family": "Michael", "given": "Strange", "initials": "S"}], "type": "journal article", "published": "2021-07-01", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "642983", "issn-l": "2296-2565"}, "abstract": "Infectious diseases exacerbated by Antimicrobial Resistance (AMR) are of increasing concern in Sweden, with multi-drug resistant strains associated with new resistance mechanisms that are emerging and spreading worldwide. Existing research has identified that sub-optimal living conditions and poor access to healthcare are significant factors in the spread and incubation of AMR strains. The article considers this linkage and the effort to control the spread of AMR in relation to migrants, highlighting deficiencies in public policy where such individuals are often increasingly exposed to those conditions that exacerbate AMR. In many of the richest countries, those conditions are not accidental, but often direct goals of policies designed with the goal of deterring migrants from staying within host countries. Without engaging with the politics around migration control, the article points to urgent need for more holistic assessment of all public policies that may, however unintentionally, undermine AMR control through worsening living conditions for vulnerable groups. The consequences of prioritizing policies meant to deliberately worsen the living conditions of migrants over avoiding those conditions that accelerate AMR spread, are today made ever apparent where new AMR strains have the potential to dwarf the societal effects of the current Covid-19 pandemic.", "doi": "10.3389/fpubh.2021.642983", "pmid": "34277534", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8281056"}], "notes": [], "created": "2021-08-05T11:13:39.031Z", "modified": "2021-08-05T11:14:00.826Z"}, {"entity": "publication", "iuid": "5392c61b27ca4aa7a750555622e66d75", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5392c61b27ca4aa7a750555622e66d75.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5392c61b27ca4aa7a750555622e66d75"}}, "title": "A Biased Analysis of the Swedish Management of Covid-19.", "authors": [{"family": "Nilson", "given": "Finn", "initials": "F"}], "type": "journal article", "published": "2021-07-01", "journal": {"title": "Health Policy Technol", "issn": "2211-8837", "pages": "100542", "issn-l": null}, "abstract": null, "doi": "10.1016/j.hlpt.2021.100542", "pmid": "34226863", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2211-8837(21)00065-4"}, {"db": "pmc", "key": "PMC8245297"}], "notes": [], "created": "2021-08-06T08:40:52.431Z", "modified": "2021-08-06T08:40:52.442Z"}, {"entity": "publication", "iuid": "1513bb866e3e43a8874229b2b52a121b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1513bb866e3e43a8874229b2b52a121b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1513bb866e3e43a8874229b2b52a121b"}}, "title": "Waterborne outbreak in a rural area in Greece during the COVID-19 pandemic: contribution of community pharmacies.", "authors": [{"family": "Mellou", "given": "Kassiani", "initials": "K"}, {"family": "Sideroglou", "given": "Theologia", "initials": "T"}, {"family": "Kefaloudi", "given": "Chrysovalanti", "initials": "C"}, {"family": "Tryfinopoulou", "given": "Kyriaki", "initials": "K"}, {"family": "Chrysostomou", "given": "Anthi", "initials": "A"}, {"family": "Mandilara", "given": "Georgia", "initials": "G"}, {"family": "Pavlaki", "given": "Maria", "initials": "M"}, {"family": "Maltezou", "given": "Helena C", "initials": "HC"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Rural Remote Health", "issn": "1445-6354", "volume": "21", "issue": "3", "pages": "6630", "issn-l": null}, "abstract": "On 15 June 2020, the National Public Health Organization was informed about the identification of two cases of Escherichia coli &Omicron;157 infection in a small town in the Peloponnese Region in Greece and we suspected an outbreak.\n\nWe asked the local pharmacist to assist us to verify the outbreak by providing the daily number of over-the-counter anti-diarrheal drugs sold from 20 May 2020 onwards. The pharmacist asked customers with gastroenteritis to submit stool samples at the local hospital. Samples were tested for 22 pathogens. We conducted a 1 : 1 case-control study. Cases and controls were retrieved from the pharmacy client list. Chlorination records of the water supply system were retrieved, and water samples were tested for microbiological indicators and viruses.\n\nThe increased number of sales of anti-diarrheal drugs verified the outbreak. Overall, 58 cases and 57 controls were recruited for the study. Tap water consumption (odds ratio (OR)=10.9, 95% confidence interval (CI)=3.1-38.0, p<0.001) and consumption of ice cubes made from tap water (OR=39.3, 95%CI=10.3-150.9, p<0.001) were independently associated with gastroenteritis occurrence. Eleven stool samples were tested; one was positive for shigatoxin-producing E. coli, one for enteropathogenic E. coli, four for E. coli O157 and one for Salmonella spp. Four samples tested negative. Five water samples collected on 18 June tested negative. The residual chlorine on 5 and 14 June ranged from 0.12 mg/L to 0.14 mg/L.\n\nThis was the first investigation of a waterborne outbreak in Greece performed with the collaboration of a local pharmacy. The COVID-19 pandemic favored the use of alternative resources and channels of communication with the local population, which can also be used in the future, especially in remote areas of the country.", "doi": "10.22605/RRH6630", "pmid": "34320325", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6630"}], "notes": [], "created": "2021-08-05T06:46:48.191Z", "modified": "2021-08-05T06:47:13.916Z"}, {"entity": "publication", "iuid": "9fdc18bf13a640e587387b79dde9daad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9fdc18bf13a640e587387b79dde9daad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9fdc18bf13a640e587387b79dde9daad"}}, "title": "Vaccine effectiveness against symptomatic SARS-CoV-2 infection in adults aged 65 years and older in primary care: I-MOVE-COVID-19 project, Europe, December 2020 to May 2021.", "authors": [{"family": "Kissling", "given": "Esther", "initials": "E"}, {"family": "Hooiveld", "given": "Mariette", "initials": "M"}, {"family": "Sandonis Mart\u00edn", "given": "Virginia", "initials": "V"}, {"family": "Mart\u00ednez-Baz", "given": "Iv\u00e1n", "initials": "I"}, {"family": "William", "given": "Naoma", "initials": "N"}, {"family": "Vilcu", "given": "Ana-Maria", "initials": "AM"}, {"family": "Mazagatos", "given": "Clara", "initials": "C"}, {"family": "Domegan", "given": "Lisa", "initials": "L"}, {"family": "de Lusignan", "given": "Simon", "initials": "S"}, {"family": "Meijer", "given": "Adam", "initials": "A"}, {"family": "Machado", "given": "Ausenda", "initials": "A"}, {"family": "Brytting", "given": "Mia", "initials": "M"}, {"family": "Casado", "given": "Itziar", "initials": "I"}, {"family": "Murray", "given": "Josephine-L K", "initials": "JK"}, {"family": "Belhillil", "given": "Sylvie", "initials": "S"}, {"family": "Larrauri", "given": "Amparo", "initials": "A"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}, {"family": "Tsang", "given": "Ruby", "initials": "R"}, {"family": "de Lange", "given": "Marit", "initials": "M"}, {"family": "Rodrigues", "given": "Ana Paula", "initials": "AP"}, {"family": "Riess", "given": "Maximilian", "initials": "M"}, {"family": "Castilla", "given": "Jes\u00fas", "initials": "J"}, {"family": "Hamilton", "given": "Mark", "initials": "M"}, {"family": "Falchi", "given": "Alessandra", "initials": "A"}, {"family": "Pozo", "given": "Francisco", "initials": "F"}, {"family": "Dunford", "given": "Linda", "initials": "L"}, {"family": "Cogdale", "given": "Jade", "initials": "J"}, {"family": "Jansen", "given": "Tessa", "initials": "T"}, {"family": "Guiomar", "given": "Raquel", "initials": "R"}, {"family": "Enkirch", "given": "Theresa", "initials": "T"}, {"family": "Burgui", "given": "Cristina", "initials": "C"}, {"family": "Sigerson", "given": "Debbie", "initials": "D"}, {"family": "Blanchon", "given": "Thierry", "initials": "T"}, {"family": "Mart\u00ednez Ochoa", "given": "Eva Mar\u00eda", "initials": "EM"}, {"family": "Connell", "given": "Jeff", "initials": "J"}, {"family": "Ellis", "given": "Joanna", "initials": "J"}, {"family": "van Gageldonk-Lafeber", "given": "Rianne", "initials": "R"}, {"family": "Kislaya", "given": "Irina", "initials": "I"}, {"family": "Rose", "given": "Angela Mc", "initials": "AM"}, {"family": "Valenciano", "given": "Marta", "initials": "M"}, {"family": "I-MOVE-COVID-19 primary care study team", "given": "", "initials": ""}, {"family": "I-MOVE-COVID-19 primary care study team (in addition to authors above)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "29", "issn-l": null}, "abstract": "We measured COVID-19 vaccine effectiveness (VE) against symptomatic SARS-CoV-2 infection at primary care/outpatient level among adults \u2265 65 years old using a multicentre test-negative design in eight European countries. We included 592 SARS-CoV-2 cases and 4,372 test-negative controls in the main analysis. The VE was 62% (95% CI: 45-74) for one dose only and 89% (95% CI: 79-94) for complete vaccination. COVID-19 vaccines provide good protection against COVID-19 presentation at primary care/outpatient level, particularly among fully vaccinated individuals.", "doi": "10.2807/1560-7917.ES.2021.26.29.2100670", "pmid": "34296676", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8299744"}], "notes": [], "created": "2021-08-05T07:11:21.985Z", "modified": "2021-08-05T07:11:21.998Z"}, {"entity": "publication", "iuid": "cbf18a605ecd4c1da82f040646d0ddc0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cbf18a605ecd4c1da82f040646d0ddc0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cbf18a605ecd4c1da82f040646d0ddc0"}}, "title": "The risk for a new COVID-19 wave and how it depends on R 0, the current immunity level and current restrictions.", "authors": [{"family": "Britton", "given": "Tom", "initials": "T", "orcid": "0000-0002-9228-7357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3953e83bbffb428ab0a02f335979acb2.json"}}, {"family": "Trapman", "given": "Pieter", "initials": "P", "orcid": "0000-0003-0569-1659", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a2df9c9216143cd8219de8687414709.json"}}, {"family": "Ball", "given": "Frank", "initials": "F"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "R Soc Open Sci", "issn": "2054-5703", "issn-l": null, "volume": "8", "issue": "7", "pages": "210386"}, "abstract": "The COVID-19 pandemic has hit different regions differently. The current disease-induced immunity level \u00ee in a region approximately equals the cumulative fraction infected, which primarily depends on two factors: (i) the initial potential for COVID-19 in the region (R 0), and (ii) the preventive measures put in place. Using a mathematical model including heterogeneities owing to age, social activity and susceptibility, and allowing for time-varying preventive measures, the risk for a new epidemic wave and its doubling time are investigated. Focus lies on quantifying the minimal overall effect of preventive measures p Min needed to prevent a future outbreak. It is shown that \u00ee plays a more influential roll than when immunity is obtained from vaccination. Secondly, by comparing regions with different R 0 and \u00ee it is shown that regions with lower R 0 and low \u00ee may need higher preventive measures (p Min) compared with regions having higher R 0 but also higher \u00ee, even when such immunity levels are far from herd immunity. Our results are illustrated on different regions but these comparisons contain lots of uncertainty due to simplistic model assumptions and insufficient data fitting, and should accordingly be interpreted with caution.", "doi": "10.1098/rsos.210386", "pmid": "34350017", "labels": {"Funder: VR": null, "Category: Other": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8316802"}, {"db": "pii", "key": "rsos210386"}, {"db": "figshare", "key": "10.6084/m9.figshare.c.5526951"}], "notes": [], "created": "2021-08-06T08:58:06.739Z", "modified": "2023-06-19T15:26:02.530Z"}, {"entity": "publication", "iuid": "a2ad894923084e0981b07ac6b16d99fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2ad894923084e0981b07ac6b16d99fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2ad894923084e0981b07ac6b16d99fc"}}, "title": "The Swedish public health response to COVID-19.", "authors": [{"family": "Tegnell", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "APMIS", "issn": "1600-0463", "volume": "129", "issue": "7", "pages": "320-323", "issn-l": null}, "abstract": "The Swedish COVID-19 response has received excessive attention, despite not having distinctively different goals or features than other countries. The overall response has included almost all sectors of society and cannot be described here. Instead, this paper provides a general, brief description of the response from a public health perspective, but hopefully it gives a somewhat more nuanced picture of the efforts to combat COVID-19 in Sweden.", "doi": "10.1111/apm.13112", "pmid": "33622025", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-25T12:27:51.068Z", "modified": "2023-01-13T13:48:34.318Z"}, {"entity": "publication", "iuid": "eb63c9661b144436af10c6bf0224e8e3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb63c9661b144436af10c6bf0224e8e3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb63c9661b144436af10c6bf0224e8e3"}}, "title": "Sustained prothrombotic changes in convalescent patients with COVID-19.", "authors": [{"family": "von Meijenfeldt", "given": "Fien A", "initials": "FA"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Lisman", "given": "Ton", "initials": "T"}], "type": "letter", "published": "2021-07-00", "journal": {"title": "Lancet Haematol", "issn": "2352-3026", "issn-l": null, "volume": "8", "issue": "7", "pages": "e475"}, "abstract": null, "doi": "10.1016/S2352-3026(21)00146-0", "pmid": "34171275", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2352-3026(21)00146-0"}], "notes": [], "created": "2021-06-28T17:59:24.200Z", "modified": "2021-06-28T17:59:50.081Z"}, {"entity": "publication", "iuid": "7f1ddb4d277a4da6a35521c3b9c47ae6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f1ddb4d277a4da6a35521c3b9c47ae6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f1ddb4d277a4da6a35521c3b9c47ae6"}}, "title": "Spatial clustering and contextual factors associated with hospitalisation and deaths due to COVID-19 in Sweden: a geospatial nationwide ecological study.", "authors": [{"family": "Fonseca-Rodr\u00edguez", "given": "Osvaldo", "initials": "O", "orcid": "0000-0002-0253-5928", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52ff35d4b27c4150984ca0428976d442.json"}}, {"family": "Gustafsson", "given": "Per E", "initials": "PE"}, {"family": "San Sebasti\u00e1n", "given": "Miguel", "initials": "M"}, {"family": "Connolly", "given": "Anne-Marie Fors", "initials": "AF", "orcid": "0000-0001-9215-4047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ff46cc7d9e374929a14350748727ba60.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "7", "issn-l": "2059-7908"}, "abstract": "In Sweden, thousands of hospitalisations and deaths due to COVID-19 were reported since the pandemic started. Considering the uneven spatial distribution of those severe outcomes at the municipality level, the objective of this study was, first, to identify high-risk areas for COVID-19 hospitalisations and deaths, and second, to determine the associated contextual factors with the uneven spatial distribution of both study outcomes in Sweden.\n\nThe existences of spatial autocorrelation of the standardised incidence (hospitalisations) ratio and standardised mortality ratio were investigated using Global Moran's I test. Furthermore, we applied the retrospective Poisson spatial scan statistics to identify high-risk spatial clusters. The association between the contextual demographic and socioeconomic factors and the number of hospitalisations and deaths was estimated using a quasi-Poisson generalised additive regression model.\n\nTen high-risk spatial clusters of hospitalisations and six high-risk clusters of mortality were identified in Sweden from February 2020 to October 2020. The hospitalisations and deaths were associated with three contextual variables in a multivariate model: population density (inhabitants/km2) and the proportion of immigrants (%) showed a positive association with both outcomes, while the proportion of the population aged 65+ years (%) showed a negative association.\n\nOur study identified high-risk spatial clusters for hospitalisations and deaths due to COVID-19 and the association of population density, the proportion of immigrants and the proportion of people aged 65+ years with those severe outcomes. Results indicate where public health measures must be reinforced to improve sustained and future disease control and optimise the distribution of resources.", "doi": "10.1136/bmjgh-2021-006247", "pmid": "34321234", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-006247"}, {"db": "pmc", "key": "PMC8322019"}], "notes": [], "created": "2021-08-04T17:11:28.069Z", "modified": "2021-08-04T17:11:28.132Z"}, {"entity": "publication", "iuid": "b7fbc9a0406640b780703af116bba012", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b7fbc9a0406640b780703af116bba012.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b7fbc9a0406640b780703af116bba012"}}, "title": "Spanish telemedicine data on 8 children support concept of \u2018long covid\u2019 in children", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "journal-article", "published": "2021-07-00", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "issn-l": null, "volume": "110", "issue": "7", "pages": "2284-2284"}, "abstract": "I would like to thank Drs L\u00f3pez, Grasa, Calvo and L\u00f3pez-Hortelano for their informative letter (1) where they comment on my recent paper about five children with suggested long covid (2), but also draw our attention to their Spanish-language paper on Telemedicine follow-ups for COVID-19 (3). Of note their letter in Acta Paediatrica (1) confirms that long covid often occurs in pre-adolescent and adolescent children.", "doi": "10.1111/apa.15869", "pmid": "33834529", "labels": {"Type: Other": null, "Category: Post-COVID": null}, "xrefs": [], "notes": [], "created": "2021-04-12T16:13:11.496Z", "modified": "2021-07-09T12:48:42.931Z"}, {"entity": "publication", "iuid": "d7f367ada0b544c4bc6ce0f725c010fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d7f367ada0b544c4bc6ce0f725c010fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d7f367ada0b544c4bc6ce0f725c010fc"}}, "title": "Simultaneous detection of SARS-CoV-2 and pandemic (H1N1) 2009 virus with real-time isothermal platform.", "authors": [{"family": "Yu", "given": "Lin", "initials": "L"}, {"family": "Wang", "given": "Jingyao", "initials": "J"}, {"family": "Li", "given": "Xuelong", "initials": "X"}, {"family": "Mao", "given": "Lingling", "initials": "L"}, {"family": "Sui", "given": "Yi", "initials": "Y"}, {"family": "Chen", "given": "Weihua", "initials": "W"}, {"family": "Pelechano", "given": "Vicent", "initials": "V"}, {"family": "Guo", "given": "Xing", "initials": "X"}, {"family": "Yin", "given": "Xiushan", "initials": "X"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "issn-l": null, "volume": "7", "issue": "7", "pages": "e07584"}, "abstract": "The recent ongoing outbreak of novel coronavirus SARS-CoV-2 (known as COVID-19) is a severe threat to human health worldwide. By press time, more than 3.3 million people have died from COVID-19, with many countries experiencing peaks in infections and hospitalizations. The main symptoms of infection with SARS-CoV-2 include fever, chills, coughing, shortness of breath or difficulty breathing, fatigue, muscle or body aches and pains. While the symptoms of the pandemic (H1N1) 2009 virus have many similarities to the signs and transmission routes of the novel coronavirus, e.g., fever, cough, sore throat, body aches, headache, chills and fatigue. And a few cases of serious illness, rapid progress, can appear viral pneumonia, combined with respiratory failure, multiple organ function damage, serious people can die. Therefore, there is an urgent need to develop a rapid and accurate field diagnostic method to effectively identify the two viruses and treat these early infections on time, thus helping to control the spread of the disease. Among molecular detection methods, RT-LAMP (real-time reverse transcription-loop-mediated isothermal amplification) has some advantages in pathogen detection due to its rapid, accurate and effective detection characteristics. Here, we combined the primers of the two viruses with the fluorescent probes on the RT-LAMP detection platform to detect the two viruses simultaneously. Firstly, RT-LAMP method was used respectively to detect the two viruses at different concentrations to determine the effectiveness and sensitivity of probe primers to the RNA samples. And then, the two virus samples were detected simultaneously in the same reaction tube to validate if testing for the two viruses together had an impact on the results compared to detecting alone. We verified the detection efficiency of three highly active BST variants during RT-LAMP assay. We expect that this assay can effectively and accurately distinguish COVID-19 from the pandemic (H1N1) 2009, so that these two diseases with similar symptoms can be appropriately differentiated and treated.", "doi": "10.1016/j.heliyon.2021.e07584", "pmid": "34307953", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)01687-X"}, {"db": "pmc", "key": "PMC8280398"}], "notes": [], "created": "2021-08-05T06:56:22.572Z", "modified": "2021-08-05T07:01:34.728Z"}, {"entity": "publication", "iuid": "912d74dcafbe4e84bf11743a4fb0450e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/912d74dcafbe4e84bf11743a4fb0450e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/912d74dcafbe4e84bf11743a4fb0450e"}}, "title": "Severe COVID-19 in an APS1 patient with interferon autoantibodies treated with plasmapheresis", "authors": [{"family": "Lemarquis", "given": "Andri", "initials": "A", "orcid": "0000-0001-5165-0247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e10a68ac18214c00b65b4588c115c154.json"}}, {"family": "Campbell", "given": "Tessa", "initials": "T"}, {"family": "Aranda-Guill\u00e9n", "given": "Maribel", "initials": "M"}, {"family": "Hennings", "given": "Viktoria", "initials": "V"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Wenner\u00e5s", "given": "Christine", "initials": "C"}, {"family": "Eriksson", "given": "Kristina", "initials": "K"}, {"family": "Landegren", "given": "Nils", "initials": "N"}, {"family": "Bryceson", "given": "Yenan", "initials": "Y"}, {"family": "Berg", "given": "Stefan", "initials": "S"}, {"family": "Ekwall", "given": "Olov", "initials": "O"}], "type": "journal-article", "published": "2021-07-00", "journal": {"title": "J Allergy Clin Immunol", "issn": "0091-6749", "issn-l": null, "volume": "148", "issue": "1", "pages": "96-98"}, "abstract": null, "doi": "10.1016/j.jaci.2021.03.034", "pmid": "33892926", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0091-6749(21)00556-X"}, {"db": "pmc", "key": "PMC8051851"}], "notes": [], "created": "2021-04-26T17:31:01.538Z", "modified": "2021-11-18T16:08:38.815Z"}, {"entity": "publication", "iuid": "7f22600d9ed0435997c36604a4027b70", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f22600d9ed0435997c36604a4027b70.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f22600d9ed0435997c36604a4027b70"}}, "title": "Resetting the agenda for antibiotic resistance through a health systems perspective.", "authors": [{"family": "Cars", "given": "Otto", "initials": "O"}, {"family": "Chandy", "given": "Sujith J", "initials": "SJ"}, {"family": "Mpundu", "given": "Mirfin", "initials": "M"}, {"family": "Peralta", "given": "Arturo Quizhpe", "initials": "AQ"}, {"family": "Zorzet", "given": "Anna", "initials": "A"}, {"family": "So", "given": "Anthony D", "initials": "AD"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Lancet Glob Health", "issn": "2214-109X", "volume": "9", "issue": "7", "pages": "e1022-e1027", "issn-l": null}, "abstract": "Although the individual and societal consequences of antibiotic resistance spiral upwards, coordinated action has not kept pace on a global scale. The COVID-19 pandemic has highlighted the need for resilient health systems and has resulted in an unprecedented rate of collaboration in scientific, medical, social, and political dimensions. The pandemic has also created a renewed awareness of the importance of infectious diseases and is a substantial entry point for reigniting the momentum towards containing the silent pandemic of antibiotic resistance. In this Viewpoint, we discuss the limitations in the current narrative on antibiotic resistance and how it could be improved, including concerted efforts to close essential data gaps. We discuss the need for capacity building and coordination at the national and global levels to strengthen the understanding of the importance of sustainable access to effective antibiotics for all health systems that could generate tangible links to current processes for global health and development.", "doi": "10.1016/S2214-109X(21)00163-7", "pmid": "34143980", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2214-109X(21)00163-7"}], "notes": [], "created": "2021-06-28T18:29:27.689Z", "modified": "2021-06-28T18:29:27.705Z"}, {"entity": "publication", "iuid": "edac061672b844fc99698b5d8cd78b4f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/edac061672b844fc99698b5d8cd78b4f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/edac061672b844fc99698b5d8cd78b4f"}}, "title": "Rapid diagnostic testing for SARS-CoV-2: Validation and comparison of three point-of-care antibody tests.", "authors": [{"family": "Strand", "given": "Rasmus", "initials": "R", "orcid": "0000-0002-6875-6790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32fd1184e1274c21a16cb67f4a5000de.json"}}, {"family": "Thelaus", "given": "Louise", "initials": "L"}, {"family": "Fernstr\u00f6m", "given": "Nils", "initials": "N"}, {"family": "Sunnerhagen", "given": "Torgny", "initials": "T"}, {"family": "Lindroth", "given": "Ylva", "initials": "Y"}, {"family": "Linder", "given": "Adam", "initials": "A"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "J Med Virol", "issn": "1096-9071", "volume": "93", "issue": "7", "pages": "4592-4596", "issn-l": null}, "abstract": "With the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a need for diagnostic tests has surfaced. Point-of-care (POC) antibody tests can detect immunoglobulin (Ig) G and M against SARS-CoV-2 in serum, plasma, or whole blood and give results within 15 min. Validation of the performance of such tests is needed if they are to be used in clinical practice. In this study, we evaluated three POC antibody tests. Convalescent serum samples from 47 reverse transcription-polymerase chain reaction (RT-PCR) verified patients with coronavirus disease 2019 (COVID-19) collected at least 28 days post RT-PCR diagnosis as well as 50 negative pre-COVID-19 controls were tested. The three tests (denoted the J-, N-, and Z-tests) displayed the sensitivities of 87%, 96%, and 85%, respectively, for the detection of IgG. All tests had the same specificity for IgG (98%). The tests did not differ significantly for the detection of IgG. The sensitivities for IgM were lower (15%, 67%, and 70%) and the specificities were 90%, 98%, and 90%, respectively. The positive and negative predictive values were similar among the tests. Our results indicate that these POC antibody tests might be accurate enough to use in routine clinical practice.", "doi": "10.1002/jmv.26913", "pmid": "33666238", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Proteins": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8014463"}], "notes": [], "created": "2021-03-06T10:09:55.362Z", "modified": "2021-11-18T12:47:58.452Z"}, {"entity": "publication", "iuid": "f1262619e94340d4ab08c02d5fd8f36d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1262619e94340d4ab08c02d5fd8f36d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1262619e94340d4ab08c02d5fd8f36d"}}, "title": "Privacy lost: Appropriating surveillance technology in China\u2019s fight against COVID-19", "authors": [{"family": "Liu", "given": "Jun", "initials": "J"}, {"family": "Zhao", "given": "Hui", "initials": "H"}], "type": "journal-article", "published": "2021-07-00", "journal": {"title": "Business Horizons", "issn": "0007-6813", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/j.bushor.2021.07.004", "pmid": null, "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:52:59.576Z", "modified": "2022-11-23T08:58:55.620Z"}, {"entity": "publication", "iuid": "18aa9fe62d094bfabc8c44c5c3a5e5de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18aa9fe62d094bfabc8c44c5c3a5e5de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18aa9fe62d094bfabc8c44c5c3a5e5de"}}, "title": "Monitoring lung injury with particle flow rate in LPS- and COVID-19-induced ARDS.", "authors": [{"family": "Stenlo", "given": "Martin", "initials": "M", "orcid": "0000-0001-8328-259X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/194fa048a20b4e149737bd062773b293.json"}}, {"family": "Silva", "given": "Iran A N", "initials": "IAN"}, {"family": "Hyll\u00e9n", "given": "Snejana", "initials": "S"}, {"family": "B\u00f6l\u00fckbas", "given": "Deniz A", "initials": "DA"}, {"family": "Niroomand", "given": "Anna", "initials": "A", "orcid": "0000-0002-6402-9414", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ce75bcb9bac481f93e200ea079812b4.json"}}, {"family": "Grins", "given": "Edgars", "initials": "E"}, {"family": "Ederoth", "given": "Per", "initials": "P"}, {"family": "Hallgren", "given": "Oskar", "initials": "O"}, {"family": "Pierre", "given": "Leif", "initials": "L"}, {"family": "Wagner", "given": "Darcy E", "initials": "DE", "orcid": "0000-0003-3794-1309", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a62680154e2e4ae2b7cec2c44af06c9a.json"}}, {"family": "Lindstedt", "given": "Sandra", "initials": "S", "orcid": "0000-0003-4484-6473", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0739b93800374fa789184d52aa753ffa.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Physiol Rep", "issn": "2051-817X", "volume": "9", "issue": "13", "pages": "e14802", "issn-l": null}, "abstract": "In severe acute respiratory distress syndrome (ARDS), extracorporeal membrane oxygenation (ECMO) is a life-prolonging treatment, especially among COVID-19 patients. Evaluation of lung injury progression is challenging with current techniques. Diagnostic imaging or invasive diagnostics are risky given the difficulties of intra-hospital transportation, contraindication of biopsies, and the potential for the spread of infections, such as in COVID-19 patients. We have recently shown that particle flow rate (PFR) from exhaled breath could be a noninvasive, early detection method for ARDS during mechanical ventilation. We hypothesized that PFR could also measure the progress of lung injury during ECMO treatment. Lipopolysaccharide (LPS) was thus used to induce ARDS in pigs under mechanical ventilation. Eight were connected to ECMO, whereas seven animals were not. In addition, six animals received sham treatment with saline. Four human patients with ECMO and ARDS were also monitored. In the pigs, as lung injury ensued, the PFR dramatically increased and a particular spike followed the establishment of ECMO in the LPS-treated animals. PFR remained elevated in all animals with no signs of lung recovery. In the human patients, in the two that recovered, PFR decreased. In the two whose lung function deteriorated while on ECMO, there was increased PFR with no sign of recovery in lung function. The present results indicate that real-time monitoring of PFR may be a new, complementary approach in the clinic for measurement of the extent of lung injury and recovery over time in ECMO patients with ARDS.", "doi": "10.14814/phy2.14802", "pmid": "34250766", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8273428"}], "notes": [], "created": "2021-08-06T07:49:20.116Z", "modified": "2021-08-06T07:49:20.217Z"}, {"entity": "publication", "iuid": "f111b8fca3e6412b8110ce03ded40ceb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f111b8fca3e6412b8110ce03ded40ceb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f111b8fca3e6412b8110ce03ded40ceb"}}, "title": "Lessons from COVID.", "authors": [{"family": "Kitson", "given": "Alison", "initials": "A", "orcid": "0000-0003-3053-8381", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7dd7640c23354063aab9385f22eaf4af.json"}}, {"family": "Huisman-de Waal", "given": "Getty", "initials": "G"}, {"family": "Muntlin", "given": "Asa", "initials": "A"}], "type": "editorial", "published": "2021-07-00", "journal": {"title": "J Adv Nurs", "issn": "1365-2648", "volume": "77", "issue": "7", "pages": "e7-e9", "issn-l": null}, "abstract": null, "doi": "10.1111/jan.14844", "pmid": "33780039", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-03-30T12:25:58.304Z", "modified": "2023-01-13T13:35:08.253Z"}, {"entity": "publication", "iuid": "774079bedc1a47c5a03107c4ae2b68e4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/774079bedc1a47c5a03107c4ae2b68e4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/774079bedc1a47c5a03107c4ae2b68e4"}}, "title": "Intrauterine vertical SARS-CoV-2 infection: a case confirming transplacental transmission followed by divergence of the viral genome.", "authors": [{"family": "Zaigham", "given": "M", "initials": "M", "orcid": "0000-0003-0129-1578", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/168018c2beee4b99868263d77bb67277.json"}}, {"family": "Holmberg", "given": "A", "initials": "A"}, {"family": "Karlberg", "given": "M L", "initials": "ML"}, {"family": "Lindsj\u00f6", "given": "O K", "initials": "OK"}, {"family": "Jokubkiene", "given": "L", "initials": "L"}, {"family": "Sandblom", "given": "J", "initials": "J"}, {"family": "Strand", "given": "A S", "initials": "AS"}, {"family": "Andersson", "given": "O", "initials": "O"}, {"family": "Hansson", "given": "S R", "initials": "SR"}, {"family": "Nord", "given": "D G", "initials": "DG"}, {"family": "Tannenberg", "given": "P", "initials": "P"}], "type": "case reports", "published": "2021-07-00", "journal": {"title": "BJOG", "issn": "1471-0528", "volume": "128", "issue": "8", "pages": "1388-1394", "issn-l": null}, "abstract": "A 27-year-old woman (gravida 2, para 1) was transported to the regional university hospital in gestational week (GW) 34 + 4 due to a three-day history of fever, abdominal pain and reduced foetal movements. She had developed a dry cough one day prior to the admission (Figure S1). The woman, was slightly overweight (BMI 27 kg/m 2 ) but otherwise healthy. She had normal antenatal check-ups and an obstetric ultrasound at GW 32 + 2 showed a normal foetal weight deviation of +8%1 .", "doi": "10.1111/1471-0528.16682", "pmid": "33638908", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8013698"}], "notes": [], "created": "2021-03-01T10:26:44.679Z", "modified": "2021-11-18T11:58:29.481Z"}, {"entity": "publication", "iuid": "04206c294cbe4fceb756221db3d0b598", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/04206c294cbe4fceb756221db3d0b598.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/04206c294cbe4fceb756221db3d0b598"}}, "title": "Impact of pathogen reduction methods on immunological properties of the COVID-19 convalescent plasma.", "authors": [{"family": "Kostin", "given": "Alexander I", "initials": "AI", "orcid": "0000-0001-7542-851X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a28d5c0e69df478a84d89c91d83f0068.json"}}, {"family": "Lundgren", "given": "Maria N", "initials": "MN", "orcid": "0000-0001-8081-962X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8000a3de30e4a42a2397c3561adb685.json"}}, {"family": "Bulanov", "given": "Andrey Y", "initials": "AY", "orcid": "0000-0001-6999-8145", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/739b725cb6ed4bc4a39ab94fef9c0b1a.json"}}, {"family": "Ladygina", "given": "Elena A", "initials": "EA", "orcid": "0000-0001-7343-0667", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d3950fb8d5a47528353602e7f3bc81b.json"}}, {"family": "Chirkova", "given": "Karina S", "initials": "KS", "orcid": "0000-0003-2583-9956", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a8097f7620b42d8a7f0499f13e3e079.json"}}, {"family": "Gintsburg", "given": "Alexander L", "initials": "AL", "orcid": "0000-0003-1769-5059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2431d07e4df14514832bd495b68881fb.json"}}, {"family": "Logunov", "given": "Denis Y", "initials": "DY", "orcid": "0000-0003-4035-6581", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/66576c7bb29446cba136c9d019e0dfeb.json"}}, {"family": "Dolzhikova", "given": "Inna V", "initials": "IV", "orcid": "0000-0003-2548-6142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d48dc829d0346c1bf6220c25091ee47.json"}}, {"family": "Shcheblyakov", "given": "Dmitry V", "initials": "DV", "orcid": "0000-0002-1289-3411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9966082c61f4ed29f5e6e5d9416d109.json"}}, {"family": "Borovkova", "given": "Natalia V", "initials": "NV", "orcid": "0000-0002-8897-7523", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eaca90ac5bf5475abf8f994e18b79402.json"}}, {"family": "Godkov", "given": "Mikhail A", "initials": "MA", "orcid": "0000-0001-9612-6705", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/83b007f636504bc7a4743146e6e897cf.json"}}, {"family": "Bazhenov", "given": "Alexey I", "initials": "AI", "orcid": "0000-0002-1926-145X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a35e87f647f4945982b3077b72e038c.json"}}, {"family": "Shustov", "given": "Valeriy V", "initials": "VV", "orcid": "0000-0002-9624-5883", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74087b1795364165b659eaa9c13071a2.json"}}, {"family": "Bogdanova", "given": "Alina S", "initials": "AS", "orcid": "0000-0002-6608-8493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04f6332b01c24d709ebffc160911f661.json"}}, {"family": "Kamalova", "given": "Alina R", "initials": "AR", "orcid": "0000-0001-8022-8491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1664eb55ddfd44f78a90ecfa31e61603.json"}}, {"family": "Ganchin", "given": "Vladimir V", "initials": "VV", "orcid": "0000-0001-9138-6479", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8282794964834c2f818f8622f18931f5.json"}}, {"family": "Dombrovskiy", "given": "Eugene A", "initials": "EA", "orcid": "0000-0002-3154-3564", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/416da0dc54b642158bfa85aff8763979.json"}}, {"family": "Volkov", "given": "Stanislav E", "initials": "SE", "orcid": "0000-0001-5289-2256", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b60e88f4ce9740b0ad315065b9fce6c5.json"}}, {"family": "Drozdova", "given": "Nataliya E", "initials": "NE", "orcid": "0000-0001-9374-6554", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bac7ac296eb942a884f56fe03d385c01.json"}}, {"family": "Petrikov", "given": "Sergey S", "initials": "SS", "orcid": "0000-0003-3292-8789", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d28e63ecffcc469ca8f1bc5ec08d392b.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Vox Sang", "issn": "1423-0410", "volume": "116", "issue": "6", "pages": "665-672", "issn-l": null}, "abstract": "COVID-19 convalescent plasma is an experimental treatment against SARS-CoV-2. The aim of this study is to assess the impact of different pathogen reduction methods on the levels and virus neutralizing activity of the specific antibodies against SARS-CoV2 in convalescent plasma.\n\nA total of 140 plasma doses collected by plasmapheresis from COVID-19 convalescent donors were subjected to pathogen reduction by three methods: methylene blue (M)/visible light, riboflavin (R)/UVB and amotosalen (A)/UVA. To conduct a paired comparison, individual plasma doses were divided into 2 samples that were subjected to one of these methods. The titres of SARS-CoV2 neutralizing antibodies (NtAbs) and levels of specific immunoglobulins to RBD, S- and N-proteins of SARS-CoV-2 were measured before and after pathogen reduction.\n\nThe methods reduced NtAbs titres differently: among units with the initial titre 80 or above, 81% of units remained unchanged and 19% decreased by one step after methylene blue; 60% were unchanged and 40% decreased by one step after amotosalen; after riboflavin 43% were unchanged and 50% (7%, respectively) had a one-step (two-step, respectively) decrease. Paired two-sample comparisons (M vs. A, M vs. R and A vs. R) revealed that the largest statistically significant decrease in quantity and activity of the specific antibodies resulted from the riboflavin treatment.\n\nPathogen reduction with methylene blue or with amotosalen provides the greater likelihood of preserving the immunological properties of the COVID-19 convalescent plasma compared to riboflavin.", "doi": "10.1111/vox.13056", "pmid": "33734455", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8250394"}], "notes": [], "created": "2021-03-22T10:49:56.136Z", "modified": "2021-11-18T13:46:53.300Z"}, {"entity": "publication", "iuid": "5961f60ecefc450babce1e2642161dc1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5961f60ecefc450babce1e2642161dc1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5961f60ecefc450babce1e2642161dc1"}}, "title": "Higher vs lower doses of dexamethasone in patients with COVID\u201019 and severe hypoxia (COVID STEROID 2) trial: Protocol and statistical analysis plan", "authors": [{"family": "Munch", "given": "MW", "initials": "M", "orcid": "0000-0003-1127-9599", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd56f64f991042da935f6f3836e087b0.json"}}, {"family": "Granholm", "given": "Anders", "initials": "A"}, {"family": "Myatra", "given": "SN", "initials": "S"}, {"family": "Vijayaraghavan", "given": "BKT", "initials": "B"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Wahlin", "given": "RR", "initials": "R"}, {"family": "Jakob", "given": "Stephan M", "initials": "SM"}, {"family": "Cioccari", "given": "Luca", "initials": "L"}, {"family": "Kj\u00e6r", "given": "MN", "initials": "M", "orcid": "0000-0002-6536-0504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df8fa07399b448a5b689089e505dab58.json"}}, {"family": "Vesterlund", "given": "GK", "initials": "G", "orcid": "0000-0001-5221-3938", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6eb5ff4bc5054887bfac267b8c8af411.json"}}, {"family": "Meyhoff", "given": "TS", "initials": "T", "orcid": "0000-0002-1840-1596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/766fe5fd044944faabf6a96e8d6a72f0.json"}}, {"family": "Helleberg", "given": "Marie", "initials": "M"}, {"family": "M\u00f8ller", "given": "MH", "initials": "M", "orcid": "0000-0002-6378-9673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1cf88aaa5c9436a8e70ddfe39cfe4e8.json"}}, {"family": "Benfield", "given": "Thomas", "initials": "T"}, {"family": "Venkatesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Hammond", "given": "Naomi", "initials": "N"}, {"family": "Micallef", "given": "Sharon", "initials": "S"}, {"family": "Bassi", "given": "Abhinav", "initials": "A"}, {"family": "John", "given": "Oommen", "initials": "O"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Kristiansen", "given": "KT", "initials": "K"}, {"family": "Ulrik", "given": "CS", "initials": "C"}, {"family": "J\u00f8rgensen", "given": "VL", "initials": "V"}, {"family": "Smitt", "given": "Margit", "initials": "M"}, {"family": "Bestle", "given": "Morten H", "initials": "MH"}, {"family": "Andreasen", "given": "AS", "initials": "A"}, {"family": "Poulsen", "given": "LM", "initials": "L"}, {"family": "Rasmussen", "given": "BS", "initials": "B", "orcid": "0000-0003-2190-145X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa66146077394afea60f71d4be6daf06.json"}}, {"family": "Br\u00f8chner", "given": "AC", "initials": "A"}, {"family": "Str\u00f8m", "given": "Thomas", "initials": "T"}, {"family": "M\u00f8ller", "given": "Anders", "initials": "A"}, {"family": "Khan", "given": "MS", "initials": "M"}, {"family": "Padmanaban", "given": "Ajay", "initials": "A"}, {"family": "Divatia", "given": "JV", "initials": "J"}, {"family": "Saseedharan", "given": "Sanjith", "initials": "S"}, {"family": "Borawake", "given": "Kapil", "initials": "K"}, {"family": "Kapadia", "given": "Farhad", "initials": "F"}, {"family": "Dixit", "given": "Subhal", "initials": "S"}, {"family": "Chawla", "given": "Rajesh", "initials": "R"}, {"family": "Shukla", "given": "Urvi", "initials": "U"}, {"family": "Amin", "given": "Pravin", "initials": "P"}, {"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Lange", "given": "Theis", "initials": "T"}, {"family": "Perner", "given": "Anders", "initials": "A", "orcid": "0000-0002-4668-0123", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5d5120bc69c433f9df2b929d6be905a.json"}}], "type": "journal-article", "published": "2021-07-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "0001-5172", "volume": "65", "issue": "6", "pages": "834-845", "issn-l": null}, "abstract": null, "doi": "10.1111/aas.13795", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-15T07:49:08.383Z", "modified": "2021-06-18T12:04:56.569Z"}, {"entity": "publication", "iuid": "f2856ad6b78843f286c681e2ad60aa62", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f2856ad6b78843f286c681e2ad60aa62.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f2856ad6b78843f286c681e2ad60aa62"}}, "title": "Gambling and self-reported changes in gambling during COVID-19 in web survey respondents in Denmark.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": "7", "issue": "7", "pages": "e07506", "issn-l": null}, "abstract": "Problem gambling is among the public health hazards which may increase due to the COVID-19 pandemic and its consequences on society. Results from a few countries have hitherto been diverse with respect to gambling during the pandemic. The present study aimed to study gambling behaviors during COVID-19 in Denmark, with the same methodology as previously used in Sweden, and also to provide a comparison to previously published Swedish data. A web survey was answered by 2,012 individuals, from December 2, to December 10, 2020. Four percent reported increased gambling habits, and three percent reported decreased gambling, during COVID-19. Self-reported increase in gambling was associated with spending more time at home, mental distress, and higher gambling severity. Prevalence of self-reported, increased gaming during COVID-19 was significantly lower in Denmark than in Sweden. Although the overall changes in gambling patterns during COVID-19 may be limited, people who increase their gambling during the pandemic may be at particular risk. Stakeholders should pay attention to individuals who report altered gambling habits during the pandemic.", "doi": "10.1016/j.heliyon.2021.e07506", "pmid": "34337174", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)01609-1"}, {"db": "pmc", "key": "PMC8318852"}], "notes": [], "created": "2021-08-04T10:11:54.307Z", "modified": "2021-08-04T10:12:15.975Z"}, {"entity": "publication", "iuid": "97ef8fbfc7b64b0b847e5d76a17538e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/97ef8fbfc7b64b0b847e5d76a17538e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/97ef8fbfc7b64b0b847e5d76a17538e1"}}, "title": "Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry.", "authors": [{"family": "Strangfeld", "given": "Anja", "initials": "A", "orcid": "0000-0002-6233-022X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/644005e83dff44b7bdca5d2b818e17d5.json"}}, {"family": "Sch\u00e4fer", "given": "Martin", "initials": "M"}, {"family": "Gianfrancesco", "given": "Milena A", "initials": "MA"}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S"}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Ljung", "given": "Lotta", "initials": "L", "orcid": "0000-0001-8999-0925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/709689ef8ef54a80a79c7db9ad2d9de8.json"}}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Richez", "given": "Christophe", "initials": "C", "orcid": "0000-0002-3029-8739", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eade13f96ed49bd8a656c07a8f6ced8.json"}}, {"family": "Santos", "given": "Maria J", "initials": "MJ", "orcid": "0000-0002-7946-1365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d031d58f434247fd83359ee0c7602db5.json"}}, {"family": "Schmajuk", "given": "Gabriela", "initials": "G"}, {"family": "Scir\u00e8", "given": "Carlo A", "initials": "CA", "orcid": "0000-0001-7451-0271", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76ebc6c1acb94b2780a38dc4e8aea708.json"}}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA"}, {"family": "Sufka", "given": "Paul", "initials": "P"}, {"family": "Thomas", "given": "Thierry", "initials": "T"}, {"family": "Trupin", "given": "Laura", "initials": "L"}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Al-Adely", "given": "Sarah", "initials": "S"}, {"family": "Bachiller-Corral", "given": "Javier", "initials": "J", "orcid": "0000-0001-8954-209X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a1aaa97213840fe8ab9108b4574e9a5.json"}}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Cacoub", "given": "Patrice", "initials": "P"}, {"family": "Carmona", "given": "Loreto", "initials": "L", "orcid": "0000-0002-4401-2551", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/798721bfd6a14e2f95267a56c5750ebe.json"}}, {"family": "Costello", "given": "Ruth", "initials": "R", "orcid": "0000-0003-2709-6666", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8c0fe69f61b54ab89f9a3de852f872a8.json"}}, {"family": "Costello", "given": "Wendy", "initials": "W"}, {"family": "Gossec", "given": "Laure", "initials": "L", "orcid": "0000-0002-4528-310X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be93914dbc9b4abb936cbcaf202de05f.json"}}, {"family": "Grainger", "given": "Rebecca", "initials": "R"}, {"family": "Hachulla", "given": "Eric", "initials": "E", "orcid": "0000-0001-7432-847X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20bee300407547bc8d669593ff7b2764.json"}}, {"family": "Hasseli", "given": "Rebecca", "initials": "R", "orcid": "0000-0002-2982-8253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aac4e1f1ceab4e72bb816a40c2f80c44.json"}}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS", "orcid": "0000-0003-0786-8788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d99dc166f48d4af7b8e46dc999c7444b.json"}}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL", "orcid": "0000-0001-8242-9262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9ad49b088eb467ba6d1ca1559b88047.json"}}, {"family": "Izadi", "given": "Zara", "initials": "Z"}, {"family": "Jacobsohn", "given": "Lindsay", "initials": "L"}, {"family": "Katz", "given": "Patricia", "initials": "P"}, {"family": "Kearsley-Fleet", "given": "Lianne", "initials": "L", "orcid": "0000-0003-0377-1575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9cc64aac266462baf67998b3d49c6f7.json"}}, {"family": "Robinson", "given": "Philip C", "initials": "PC", "orcid": "0000-0002-3156-3418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/950b622d31724172817ccde09902d215.json"}}, {"family": "Yazdany", "given": "Jinoos", "initials": "J"}, {"family": "Machado", "given": "Pedro M", "initials": "PM", "orcid": "0000-0002-8411-7972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef40d1eea57946e4a37d2e92a02a47cd.json"}}, {"family": "COVID-19 Global Rheumatology Alliance", "given": "", "initials": ""}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Ann Rheum Dis", "issn": "1468-2060", "volume": "80", "issue": "7", "pages": "930-942", "issn-l": null}, "abstract": "To determine factors associated with COVID-19-related death in people with rheumatic diseases.\n\nPhysician-reported registry of adults with rheumatic disease and confirmed or presumptive COVID-19 (from 24 March to 1 July 2020). The primary outcome was COVID-19-related death. Age, sex, smoking status, comorbidities, rheumatic disease diagnosis, disease activity and medications were included as covariates in multivariable logistic regression models. Analyses were further stratified according to rheumatic disease category.\n\nOf 3729 patients (mean age 57 years, 68% female), 390 (10.5%) died. Independent factors associated with COVID-19-related death were age (66-75 years: OR 3.00, 95% CI 2.13 to 4.22; >75 years: 6.18, 4.47 to 8.53; both vs \u226465 years), male sex (1.46, 1.11 to 1.91), hypertension combined with cardiovascular disease (1.89, 1.31 to 2.73), chronic lung disease (1.68, 1.26 to 2.25) and prednisolone-equivalent dosage >10 mg/day (1.69, 1.18 to 2.41; vs no glucocorticoid intake). Moderate/high disease activity (vs remission/low disease activity) was associated with higher odds of death (1.87, 1.27 to 2.77). Rituximab (4.04, 2.32 to 7.03), sulfasalazine (3.60, 1.66 to 7.78), immunosuppressants (azathioprine, cyclophosphamide, ciclosporin, mycophenolate or tacrolimus: 2.22, 1.43 to 3.46) and not receiving any disease-modifying anti-rheumatic drug (DMARD) (2.11, 1.48 to 3.01) were associated with higher odds of death, compared with methotrexate monotherapy. Other synthetic/biological DMARDs were not associated with COVID-19-related death.\n\nAmong people with rheumatic disease, COVID-19-related death was associated with known general factors (older age, male sex and specific comorbidities) and disease-specific factors (disease activity and specific medications). The association with moderate/high disease activity highlights the importance of adequate disease control with DMARDs, preferably without increasing glucocorticoid dosages. Caution may be required with rituximab, sulfasalazine and some immunosuppressants.", "doi": "10.1136/annrheumdis-2020-219498", "pmid": "33504483", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7843211"}, {"db": "pii", "key": "annrheumdis-2020-219498"}], "notes": [], "created": "2021-01-29T15:13:40.304Z", "modified": "2023-06-19T14:10:28.427Z"}, {"entity": "publication", "iuid": "facda1393fe04db9932c289dd0bcd4f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/facda1393fe04db9932c289dd0bcd4f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/facda1393fe04db9932c289dd0bcd4f0"}}, "title": "Editor's Choice - The Impact of Covid-19 on Vascular Procedures in Sweden 2020.", "authors": [{"family": "Bj\u00f6rses", "given": "Katarina", "initials": "K"}, {"family": "Blomgren", "given": "Lena", "initials": "L"}, {"family": "Holsti", "given": "Mari", "initials": "M"}, {"family": "Jonsson", "given": "Magnus", "initials": "M"}, {"family": "Smidfelt", "given": "Kristian", "initials": "K"}, {"family": "Mani", "given": "Kevin", "initials": "K"}], "type": "letter", "published": "2021-07-00", "journal": {"title": "Eur J Vasc Endovasc Surg", "issn": "1532-2165", "issn-l": "1078-5884", "volume": "62", "issue": "1", "pages": "136-137"}, "abstract": null, "doi": "10.1016/j.ejvs.2021.04.027", "pmid": "34053841", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8098046"}, {"db": "pii", "key": "S1078-5884(21)00372-5"}], "notes": [], "created": "2021-06-04T11:30:05.360Z", "modified": "2023-01-13T14:48:38.476Z"}, {"entity": "publication", "iuid": "3f5db6dd1efd4733beb5d4486525868a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f5db6dd1efd4733beb5d4486525868a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f5db6dd1efd4733beb5d4486525868a"}}, "title": "Critical illness polyneuropathy, myopathy and neuronal biomarkers in COVID-19 patients: A prospective study.", "authors": [{"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "F\u00e4llmar", "given": "David", "initials": "D"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Ashton", "given": "Nicholas", "initials": "N"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Punga", "given": "Anna Rostedt", "initials": "AR"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Clin Neurophysiol", "issn": "1872-8952", "issn-l": null, "volume": "132", "issue": "7", "pages": "1733-1740"}, "abstract": "The aim was to characterize the electrophysiological features and plasma biomarkers of critical illness polyneuropathy (CIN) and myopathy (CIM) in coronavirus disease 2019 (COVID-19) patients with intensive care unit acquired weakness (ICUAW).\n\nAn observational ICU cohort study including adult patients admitted to the ICU at Uppsala University Hospital, Uppsala, Sweden, from March 13th to June 8th 2020. We compared the clinical, electrophysiological and plasma biomarker data between COVID-19 patients who developed CIN/CIM and those who did not. Electrophysiological characteristics were also compared between COVID-19 and non-COVID-19 ICU patients.\n\n111 COVID-19 patients were included, 11 of whom developed CIN/CIM. Patients with CIN/CIM had more severe illness; longer ICU stay, more thromboembolic events and were more frequently treated with invasive ventilation for longer than 2 weeks. In particular CIN was more frequent among COVID-19 patients with ICUAW (50%) compared with a non-COVID-19 cohort (0%, p = 0.008). Neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAp) levels were higher in the CIN/CIM group compared with those that did not develop CIN/CIM (both p = 0.001) and correlated with nerve amplitudes.\n\nCIN/CIM was more prevalent among COVID-19 ICU patients with severe illness.\n\nCOVID-19 patients who later developed CIN/CIM had significantly higher NfL and GFAp in the early phase of ICU care, suggesting their potential as predictive biomarkers for CIN/CIM.", "doi": "10.1016/j.clinph.2021.03.016", "pmid": "33875374", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Biochemistry": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "S1388-2457(21)00489-2"}, {"db": "pmc", "key": "PMC8012169"}], "notes": [], "created": "2021-04-20T17:48:37.525Z", "modified": "2021-12-12T18:08:09.693Z"}, {"entity": "publication", "iuid": "c87c3f16e8944d079f1a4fa0db3fd07d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c87c3f16e8944d079f1a4fa0db3fd07d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c87c3f16e8944d079f1a4fa0db3fd07d"}}, "title": "Central pulmonary embolism in patients with Covid-19.", "authors": [{"family": "Nordberg", "given": "Martin", "initials": "M"}, {"family": "Bankler", "given": "Sara", "initials": "S"}, {"family": "Everhov", "given": "\u00c5sa H", "initials": "\u00c5H"}, {"family": "Saraste", "given": "Deborah", "initials": "D", "orcid": "0000-0002-2931-2652", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27593429159d4605b8d3835a4c479c9d.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "volume": "53", "issue": "7", "pages": "513-520", "issn-l": "2374-4235"}, "abstract": "The purpose was to evaluate central pulmonary embolism (PE) in patients with Covid-19. The association with severe radiological pulmonary changes, prophylactic anticoagulation and ICU care was assessed.\n\nFrom 1 March until 31 May 2020, all in-hospital patients with a positive PCR for SARS-CoV-2-RNA and PE diagnosed with computed tomography pulmonary angiography were identified through diagnostic codes in medical charts. PE was characterised as central/peripheral and unilateral/bilateral. Covid-19 related lung changes were evaluated scoring the proportion of affected lung (max-score score 25) for all five lobes in both lungs. ICU and non-ICU patients were included and anticoagulant regimens were assessed.\n\nOf 1162 patients with Covid-19, 41 were diagnosed with PE (cumulative incidence 3.5%), and of these 63.4% (=overall 2.2%) had central PE. PE on admission was present in 46.3%. No differences were seen in the distribution of central vs. peripheral PE in relation to prophylactic anticoagulation (p=.317). Of ICU patients 82.4% were diagnosed with central PE compared to 50.0% among non-ICU patients (p=.05). No association was observed between the presence of central PE and the extent of radiological Covid-19 changes (p=.451). Mild (0-12 p) and severe (13-25 p) pulmonary changes were seen in 63.4% and 36.6% of patients respectively.\n\nOverall, and especially in ICU-patients, a high proportion of central PE was seen and many were diagnosed at admission. No association between central PE and prophylactic anticoagulation, or the extent of pulmonary Covid-19 changes was observed.", "doi": "10.1080/23744235.2021.1896030", "pmid": "33682582", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-09T15:36:23.979Z", "modified": "2021-11-18T12:49:39.668Z"}, {"entity": "publication", "iuid": "7a1bbe984f604d3f94c80907b7a3fcd1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a1bbe984f604d3f94c80907b7a3fcd1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a1bbe984f604d3f94c80907b7a3fcd1"}}, "title": "COVIDomic: A multi-modal cloud-based platform for identification of risk factors associated with COVID-19 severity.", "authors": [{"family": "Naumov", "given": "Vladimir", "initials": "V", "orcid": "0000-0003-3863-4925", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3908575922db49b385f95202accd91ab.json"}}, {"family": "Putin", "given": "Evgeny", "initials": "E", "orcid": "0000-0002-3012-9708", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75cf694692d94af78fa6d20713e4be85.json"}}, {"family": "Pushkov", "given": "Stefan", "initials": "S", "orcid": "0000-0002-1768-394X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fbbf0cd7a6a43818a2b308693edf670.json"}}, {"family": "Kozlova", "given": "Ekaterina", "initials": "E", "orcid": "0000-0003-2737-3694", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c21fab8ed9d743a0b2c898e11480003e.json"}}, {"family": "Romantsov", "given": "Konstantin", "initials": "K", "orcid": "0000-0003-0731-8575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76be3a4ea6964c7d81744a82113acde0.json"}}, {"family": "Kalashnikov", "given": "Alexander", "initials": "A"}, {"family": "Galkin", "given": "Fedor", "initials": "F", "orcid": "0000-0002-5709-9529", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/66f24623a3c14040b179ba9b0fd994ee.json"}}, {"family": "Tihonova", "given": "Nina", "initials": "N"}, {"family": "Shneyderman", "given": "Anastasia", "initials": "A"}, {"family": "Galkin", "given": "Egor", "initials": "E", "orcid": "0000-0001-9636-5706", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd7329726357486b93f9c01eb249c917.json"}}, {"family": "Zinkevich", "given": "Arsenii", "initials": "A"}, {"family": "Cope", "given": "Stephanie M", "initials": "SM"}, {"family": "Sethuraman", "given": "Ramanathan", "initials": "R"}, {"family": "Oprea", "given": "Tudor I", "initials": "TI", "orcid": "0000-0002-6195-6976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c480e6e946bd4c43ac430fd0309df71e.json"}}, {"family": "Pearson", "given": "Alexander T", "initials": "AT", "orcid": "0000-0003-2801-7456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/649fa71af7a0428fbd8f8d10111089c6.json"}}, {"family": "Tay", "given": "Savas", "initials": "S", "orcid": "0000-0002-1912-6020", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d47c1f069594367b8f9169d673d1dba.json"}}, {"family": "Agrawal", "given": "Nishant", "initials": "N"}, {"family": "Dubovenko", "given": "Alexey", "initials": "A", "orcid": "0000-0002-8424-5106", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f6b0af89130473aaf4b162f743ac5a8.json"}}, {"family": "Vanhaelen", "given": "Quentin", "initials": "Q", "orcid": "0000-0002-4611-2046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e78a63ea937e424a9bc7a57023bdac7f.json"}}, {"family": "Ozerov", "given": "Ivan", "initials": "I"}, {"family": "Aliper", "given": "Alex", "initials": "A", "orcid": "0000-0002-4363-0710", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4057aed986b9489b995e45a29d47eece.json"}}, {"family": "Izumchenko", "given": "Evgeny", "initials": "E"}, {"family": "Zhavoronkov", "given": "Alex", "initials": "A", "orcid": "0000-0001-7067-8966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb35e56edd4345f3be5cc72840aaa355.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "PLoS Comput Biol", "issn": "1553-7358", "issn-l": null, "volume": "17", "issue": "7", "pages": "e1009183"}, "abstract": "Coronavirus disease 2019 (COVID-19) is an acute infection of the respiratory tract that emerged in December 2019 in Wuhan, China. It was quickly established that both the symptoms and the disease severity may vary from one case to another and several strains of SARS-CoV-2 have been identified. To gain a better understanding of the wide variety of SARS-CoV-2 strains and their associated symptoms, thousands of SARS-CoV-2 genomes have been sequenced in dozens of countries. In this article, we introduce COVIDomic, a multi-omics online platform designed to facilitate the analysis and interpretation of the large amount of health data collected from patients with COVID-19. The COVIDomic platform provides a comprehensive set of bioinformatic tools for the multi-modal metatranscriptomic data analysis of COVID-19 patients to determine the origin of the coronavirus strain and the expected severity of the disease. An integrative analytical workflow, which includes microbial pathogens community analysis, COVID-19 genetic epidemiology and patient stratification, allows to analyze the presence of the most common microbial organisms, their antibiotic resistance, the severity of the infection and the set of the most probable geographical locations from which the studied strain could have originated. The online platform integrates a user friendly interface which allows easy visualization of the results. We envision this tool will not only have immediate implications for management of the ongoing COVID-19 pandemic, but will also improve our readiness to respond to other infectious outbreaks.", "doi": "10.1371/journal.pcbi.1009183", "pmid": "34260589", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8312936"}, {"db": "pii", "key": "PCOMPBIOL-D-21-00029"}], "notes": [], "created": "2021-08-06T07:21:00.826Z", "modified": "2023-06-19T07:30:59.263Z"}, {"entity": "publication", "iuid": "b4b16c88742546d48699006bd1d5fc0b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b4b16c88742546d48699006bd1d5fc0b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b4b16c88742546d48699006bd1d5fc0b"}}, "title": "COVID-19: Symptoms in Dying Residents of Nursing Homes and in Those Admitted to Hospitals.", "authors": [{"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "Martinsson", "given": "Lisa", "initials": "L"}, {"family": "Bergstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Staffan", "initials": "S"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "J Palliat Med", "issn": "1557-7740", "volume": "24", "issue": "7", "pages": "1067-1071", "issn-l": null}, "abstract": "To compare symptom prevalence and relief in residents who died in nursing homes with residents who were acutely referred to hospitals. Objective: Data on symptoms during the last week of life from the Swedish Register of Palliative Care (SRPC). Design: Nursing homes (Setting and Subjects:n = 1903 deaths) and hospitals in Sweden (n = 202 nursing home residents who were admitted to hospital before death). Data were retrieved on August 24, 2020. Residents who died in hospitals had more breakthrough symptoms of breathlessness (60% vs. 31%, Results:p < 0.0001) and delirium (41% vs. 25%, p < 0.0001) than those who died in nursing homes. When symptoms were present, complete symptom relief was seen less often in hospitals compared with nursing homes (breathlessness, 28% vs. 47%, p < 0.001; delirium, 10% vs. 35%, p < 0.0001; respiratory secretions, 30% vs. 55%, p < 0.0001). Despite access to oxygen and pharmacologic/nonpharmacologic therapies in hospitals, symptom relief in dying nursing home residents acutely admitted to hospitals was lower compared with those who died in nursing homes, possibly because of differences in patient characteristics.Conclusion:", "doi": "10.1089/jpm.2020.0688", "pmid": "33667124", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-06T10:08:49.786Z", "modified": "2021-11-18T12:46:26.602Z"}, {"entity": "publication", "iuid": "861353a5c9474b8e9a227a18527a8b24", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/861353a5c9474b8e9a227a18527a8b24.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/861353a5c9474b8e9a227a18527a8b24"}}, "title": "An outbreak caused by the SARS-CoV-2 Delta variant (B.1.617.2) in a secondary care hospital in Finland, May 2021.", "authors": [{"family": "Hetem\u00e4ki", "given": "Iivo", "initials": "I"}, {"family": "K\u00e4\u00e4ri\u00e4inen", "given": "Sohvi", "initials": "S"}, {"family": "Alho", "given": "Pirjo", "initials": "P"}, {"family": "Mikkola", "given": "Janne", "initials": "J"}, {"family": "Savolainen-Kopra", "given": "Carita", "initials": "C"}, {"family": "Ikonen", "given": "Niina", "initials": "N"}, {"family": "Nohynek", "given": "Hanna", "initials": "H"}, {"family": "Lyytik\u00e4inen", "given": "Outi", "initials": "O"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "30", "issn-l": null}, "abstract": "An outbreak caused by the SARS-CoV-2 Delta variant (B.1.617.2) spread from one inpatient in a secondary care hospital to three primary care facilities, resulting in 58 infections including 18 deaths in patients and 45 infections in healthcare workers (HCW). Only one of the deceased cases was fully vaccinated. Transmission occurred despite the use of personal protective equipment by the HCW, as advised in national guidelines, and a high two-dose COVID-19 vaccination coverage among permanent staff members in the COVID-19 cohort ward.", "doi": "10.2807/1560-7917.ES.2021.26.30.2100636", "pmid": "34328076", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-08-04T17:04:15.593Z", "modified": "2021-08-04T17:04:15.606Z"}, {"entity": "publication", "iuid": "075dd5d3c80e4e08889468b3e65d1264", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/075dd5d3c80e4e08889468b3e65d1264.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/075dd5d3c80e4e08889468b3e65d1264"}}, "title": "Acute pulmonary hypertension and short-term outcomes in severe Covid-19 patients needing intensive care.", "authors": [{"family": "Norderfeldt", "given": "Joakim", "initials": "J"}, {"family": "Liliequist", "given": "Andreas", "initials": "A"}, {"family": "Frostell", "given": "Claes", "initials": "C", "orcid": "0000-0002-7199-1310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874beab519f143db8659a7936aa46142.json"}}, {"family": "Adding", "given": "Christofer", "initials": "C"}, {"family": "Agvald", "given": "Per", "initials": "P"}, {"family": "Eriksson", "given": "Maria", "initials": "M"}, {"family": "L\u00f6nnqvist", "given": "Per-Arne", "initials": "PA", "orcid": "0000-0002-8586-1429", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c49ad645c3064040b0b4f225529e9237.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": "65", "issue": "6", "pages": "761-769"}, "abstract": "Critically ill Covid-19 pneumonia patients are likely to develop the sequence of acute pulmonary hypertension, right ventricular (RV) strain, and eventually RV failure due to known pathophysiology (endothelial inflammation plus thrombo-embolism) that promotes increased pulmonary vascular resistance and pulmonary artery pressure. This study aimed to investigate the occurrence of acute pulmonary hypertension (aPH) as per established trans-thoracic echocardiography (TTE) criteria in Covid-19 patients receiving intensive care and to explore whether short-term outcomes are affected by the presence of aPH.\n\nMedical records were reviewed for patients treated in the intensive care units at a tertiary university hospital over a month. The presence of aPH on the TTE was noted, and plasma NTproBNP and troponin were measured as markers of cardiac failure and myocardial injury, respectively. Follow-up data were collected 21 d after the performance of TTE.\n\nIn total, 26 of 67 patients (39%) had an assessed systolic pulmonary artery pressure of > 35 mmHg (group aPH), meeting the TTE definition of aPH. NTproBNP levels (median [range]: 1430 [102-30 300] vs. 470 [45-29 600] ng L-1 ; P = .0007), troponin T levels (63 [22-352] vs. 15 [5-407] ng L-1 ; P = .0002), and the 21-d mortality rate (46% vs. 7%; P < .001) were substantially higher in patients with aPH compared to patients not meeting aPH criteria.\n\nTTE-defined acute pulmonary hypertension was frequently observed in severely ill Covid-19 patients. Furthermore, aPH was linked to biomarker-defined myocardial injury and cardiac failure, as well as an almost sevenfold increase in 21-d mortality.", "doi": "10.1111/aas.13819", "pmid": "33728633", "labels": {"Category: Health": null, "Type: Journal article": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC8250592"}], "notes": [], "created": "2021-03-22T11:31:19.318Z", "modified": "2021-11-18T13:18:45.397Z"}, {"entity": "publication", "iuid": "256bb4b8a56d4afca0d477c714ea20de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/256bb4b8a56d4afca0d477c714ea20de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/256bb4b8a56d4afca0d477c714ea20de"}}, "title": "A call for standardised age-disaggregated health data.", "authors": [{"family": "Diaz", "given": "Theresa", "initials": "T"}, {"family": "Strong", "given": "Kathleen L", "initials": "KL"}, {"family": "Cao", "given": "Bochen", "initials": "B"}, {"family": "Guthold", "given": "Regina", "initials": "R"}, {"family": "Moran", "given": "Allisyn C", "initials": "AC"}, {"family": "Moller", "given": "Ann-Beth", "initials": "AB"}, {"family": "Requejo", "given": "Jennifer", "initials": "J"}, {"family": "Sadana", "given": "Ritu", "initials": "R"}, {"family": "Thiyagarajan", "given": "Jotheeswaran Amuthavalli", "initials": "JA"}, {"family": "Adebayo", "given": "Emmanuel", "initials": "E"}, {"family": "Akwara", "given": "Elsie", "initials": "E"}, {"family": "Amouzou", "given": "Agbessi", "initials": "A"}, {"family": "Aponte Varon", "given": "John J", "initials": "JJ"}, {"family": "Azzopardi", "given": "Peter S", "initials": "PS"}, {"family": "Boschi-Pinto", "given": "Cynthia", "initials": "C"}, {"family": "Carvajal", "given": "Liliana", "initials": "L"}, {"family": "Chandra-Mouli", "given": "Venkatraman", "initials": "V"}, {"family": "Crofts", "given": "Sarah", "initials": "S"}, {"family": "Dastgiri", "given": "Saeed", "initials": "S"}, {"family": "Dery", "given": "Jeremiah S", "initials": "JS"}, {"family": "Elnakib", "given": "Shatha", "initials": "S"}, {"family": "Fagan", "given": "Laura", "initials": "L"}, {"family": "Jane Ferguson", "given": "B", "initials": "B"}, {"family": "Fitzner", "given": "Julia", "initials": "J"}, {"family": "Friedman", "given": "Howard S", "initials": "HS"}, {"family": "Hagell", "given": "Ann", "initials": "A"}, {"family": "Jongstra", "given": "Eduard", "initials": "E"}, {"family": "Kann", "given": "Laura", "initials": "L"}, {"family": "Chatterji", "given": "Somnath", "initials": "S"}, {"family": "English", "given": "Mike", "initials": "M"}, {"family": "Glaziou", "given": "Philippe", "initials": "P"}, {"family": "Hanson", "given": "Claudia", "initials": "C"}, {"family": "Hosseinpoor", "given": "Ahmad R", "initials": "AR"}, {"family": "Marsh", "given": "Andrew", "initials": "A"}, {"family": "Morgan", "given": "Alison P", "initials": "AP"}, {"family": "Munos", "given": "Melinda K", "initials": "MK"}, {"family": "Noor", "given": "Abdisalan", "initials": "A"}, {"family": "Pavlin", "given": "Boris I", "initials": "BI"}, {"family": "Pereira", "given": "Rich", "initials": "R"}, {"family": "Porth", "given": "Tyler A", "initials": "TA"}, {"family": "Schellenberg", "given": "Joanna", "initials": "J"}, {"family": "Siddique", "given": "Rizwana", "initials": "R"}, {"family": "You", "given": "Danzhen", "initials": "D"}, {"family": "Vaz", "given": "Lara M E", "initials": "LME"}, {"family": "Banerjee", "given": "Anshu", "initials": "A"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Lancet Healthy Longev", "issn": "2666-7568", "volume": "2", "issue": "7", "pages": "e436-e443", "issn-l": null}, "abstract": "The 2030 Sustainable Development Goals agenda calls for health data to be disaggregated by age. However, age groupings used to record and report health data vary greatly, hindering the harmonisation, comparability, and usefulness of these data, within and across countries. This variability has become especially evident during the COVID-19 pandemic, when there was an urgent need for rapid cross-country analyses of epidemiological patterns by age to direct public health action, but such analyses were limited by the lack of standard age categories. In this Personal View, we propose a recommended set of age groupings to address this issue. These groupings are informed by age-specific patterns of morbidity, mortality, and health risks, and by opportunities for prevention and disease intervention. We recommend age groupings of 5 years for all health data, except for those younger than 5 years, during which time there are rapid biological and physiological changes that justify a finer disaggregation. Although the focus of this Personal View is on the standardisation of the analysis and display of age groups, we also outline the challenges faced in collecting data on exact age, especially for health facilities and surveillance data. The proposed age disaggregation should facilitate targeted, age-specific policies and actions for health care and disease management.", "doi": "10.1016/S2666-7568(21)00115-X", "pmid": "34240065", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2666-7568(21)00115-X"}, {"db": "pmc", "key": "PMC8245325"}], "notes": [], "created": "2021-08-06T07:59:40.130Z", "modified": "2021-08-06T07:59:49.181Z"}, {"entity": "publication", "iuid": "cacc1bbd7796404bbf4f3a9b24e217fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cacc1bbd7796404bbf4f3a9b24e217fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cacc1bbd7796404bbf4f3a9b24e217fd"}}, "title": "Up State of the SARS-COV-2 Spike Homotrimer Favors an Increased Virulence for New Variants.", "authors": [{"family": "Giron", "given": "Carolina Corr\u00eaa", "initials": "CC"}, {"family": "Laaksonen", "given": "Aatto", "initials": "A"}, {"family": "Barroso da Silva", "given": "Fernando Lu\u00eds", "initials": "FL"}], "type": "journal article", "published": "2021-06-30", "journal": {"title": "Front Med Technol", "issn": "2673-3129", "issn-l": null, "volume": "3", "issue": null, "pages": "694347"}, "abstract": "The COVID-19 pandemic has spread worldwide. However, as soon as the first vaccines-the only scientifically verified and efficient therapeutic option thus far-were released, mutations combined into variants of SARS-CoV-2 that are more transmissible and virulent emerged, raising doubts about their efficiency. This study aims to explain possible molecular mechanisms responsible for the increased transmissibility and the increased rate of hospitalizations related to the new variants. A combination of theoretical methods was employed. Constant-pH Monte Carlo simulations were carried out to quantify the stability of several spike trimeric structures at different conformational states and the free energy of interactions between the receptor-binding domain (RBD) and angiotensin-converting enzyme II (ACE2) for the most worrying variants. Electrostatic epitopes were mapped using the PROCEEDpKa method. These analyses showed that the increased virulence is more likely to be due to the improved stability to the S trimer in the opened state, in which the virus can interact with the cellular receptor, ACE2, rather than due to alterations in the complexation RBD-ACE2, since the difference observed in the free energy values was small (although more attractive in general). Conversely, the South African/Beta variant (B.1.351), compared with the SARS-CoV-2 wild type (wt), is much more stable in the opened state with one or two RBDs in the up position than in the closed state with three RBDs in the down position favoring the infection. Such results contribute to understanding the natural history of disease and indicate possible strategies for developing new therapeutic molecules and adjusting the vaccine doses for higher B-cell antibody production.", "doi": "10.3389/fmedt.2021.694347", "pmid": "35047936", "labels": {"Category: Health": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8757851"}], "notes": [], "created": "2022-01-27T07:01:54.014Z", "modified": "2022-01-27T07:03:25.405Z"}, {"entity": "publication", "iuid": "6f864b2f4ae5498b87b581187353d13f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f864b2f4ae5498b87b581187353d13f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f864b2f4ae5498b87b581187353d13f"}}, "title": "The concerns of oncology professionals during the COVID-19 pandemic: results from the ESMO Resilience Task Force survey II.", "authors": [{"family": "Lim", "given": "K H J", "initials": "KHJ"}, {"family": "Murali", "given": "K", "initials": "K"}, {"family": "Kamposioras", "given": "K", "initials": "K"}, {"family": "Punie", "given": "K", "initials": "K"}, {"family": "Oing", "given": "C", "initials": "C"}, {"family": "O'Connor", "given": "M", "initials": "M"}, {"family": "Thorne", "given": "E", "initials": "E"}, {"family": "Amaral", "given": "T", "initials": "T"}, {"family": "Garrido", "given": "P", "initials": "P"}, {"family": "Lambertini", "given": "M", "initials": "M"}, {"family": "Devnani", "given": "B", "initials": "B"}, {"family": "Westphalen", "given": "C B", "initials": "CB"}, {"family": "Morgan", "given": "G", "initials": "G"}, {"family": "Haanen", "given": "J B A G", "initials": "JBAG"}, {"family": "Hardy", "given": "C", "initials": "C"}, {"family": "Banerjee", "given": "S", "initials": "S"}], "type": "journal article", "published": "2021-06-30", "journal": {"title": "ESMO Open", "issn": "2059-7029", "volume": "6", "issue": "4", "pages": "100199", "issn-l": null}, "abstract": "The COVID-19 pandemic has resulted in significant changes to professional and personal lives of oncology professionals globally. The European Society for Medical Oncology (ESMO) Resilience Task Force collaboration aimed to provide contemporaneous reports on the impact of COVID-19 on the lived experiences and well-being in oncology.\n\nThis online anonymous survey (July-August 2020) is the second of a series of global surveys launched during the course of the pandemic. Longitudinal key outcome measures including well-being/distress (expanded Well-being Index-9 items), burnout (1 item from expanded Well-being Index), and job performance since COVID-19 were tracked.\n\nA total of 942 participants from 99 countries were included for final analysis: 58% (n = 544) from Europe, 52% (n = 485) female, 43% (n = 409) \u226440 years old, and 36% (n = 343) of non-white ethnicity. In July/August 2020, 60% (n = 525) continued to report a change in professional duties compared with the pre-COVID-19 era. The proportion of participants at risk of poor well-being (33%, n = 310) and who reported feeling burnout (49%, n = 460) had increased significantly compared with April/May 2020 (25% and 38%, respectively; P < 0.001), despite improved job performance since COVID-19 (34% versus 51%; P < 0.001). Of those who had been tested for COVID-19, 8% (n = 39/484) tested positive; 18% (n = 7/39) felt they had not been given adequate time to recover before return to work. Since the pandemic, 39% (n = 353/908) had expressed concerns that COVID-19 would have a negative impact on their career development or training and 40% (n = 366/917) felt that their job security had been compromised. More than two-thirds (n = 608/879) revealed that COVID-19 has changed their outlook on their work-personal life balance.\n\nThe COVID-19 pandemic continues to impact the well-being of oncology professionals globally, with significantly more in distress and feeling burnout compared with the first wave. Collective efforts from both national and international communities addressing support and coping strategies will be crucial as we recover from the COVID-19 crisis. In particular, an action plan should also be devised to tackle concerns raised regarding the negative impact of COVID-19 on career development, training, and job security.", "doi": "10.1016/j.esmoop.2021.100199", "pmid": "34217129", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2059-7029(21)00160-5"}], "notes": [], "created": "2021-07-05T15:03:06.220Z", "modified": "2021-07-05T15:03:54.367Z"}, {"entity": "publication", "iuid": "9be4d53064af40d2b097b15b815355dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9be4d53064af40d2b097b15b815355dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9be4d53064af40d2b097b15b815355dd"}}, "title": "Summary of European guidelines on infection control and prevention during COVID-19 pandemic.", "authors": [{"family": "Becker", "given": "Kathrin", "initials": "K", "orcid": "0000-0003-1936-4683", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cfa273f3515e470c87ad24540f6398f0.json"}}, {"family": "Gurzawska-Comis", "given": "Katarzyna", "initials": "K", "orcid": "0000-0002-3424-5968", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2b36d90d1804c67aa844537ce625fe7.json"}}, {"family": "Brunello", "given": "Giulia", "initials": "G", "orcid": "0000-0003-1436-0085", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c41e6e7b6a6d4070ba5e61aec8e085ad.json"}}, {"family": "Klinge", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0003-2100-2446", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b0a71c3b5b93430c817278f62204b5db.json"}}], "type": "journal article", "published": "2021-06-30", "journal": {"title": "Clin Oral Implants Res", "issn": "1600-0501", "issn-l": null}, "abstract": "The current COVID-19 pandemic highlighted the need for a review of guidelines on infection control and prevention to ensure safe delivery of dental care. However, it is not clear to what extent the rapidly published European guidelines reflect the current evidence and thus provide homogeneous recommendations.\n\nGuidelines from all European Union countries, Scotland, Switzerland and United Kingdom were retrieved. Information on triage, mouth rinse, personal protective equipment (PPE) for aerosol free/ generating procedures (non-AGP/AGP) and treatment of potentially infectious patients were summarised, and compared with recommendations from international organizations (WHO, ECDC, CDC).\n\nAll included countries (30/30) published COVID-19 guidelines in 2020. All countries recommended triage and to postpone non-urgent treatment of potentially infectious patients. Hydrogen peroxide (1-1.5%) was the most frequently recommended antiseptic mouth rinse to reduce viral load (24/30). PPE for non-AGP treatments included mainly surgical masks (21/30) or FFP2/FFP3/N95 masks (16/30), whereas FFP2/FFP3 masks (25/30) and face shields (24/30) were recommended for AGP by the vast majority of guidelines. For high-risk/COVID positive patients, most countries recommended maximum protection, and treatment in specialised dental clinics (22/30).\n\nThere was general agreement among recommendations for triage, mouth rinse, and PPE during AGP and treatment of potentially infectious patients. In contrast, recommendations on PPE for non-AGP treatment varied considerably among the European countries possibly due to limited scientific evidence regarding transmission risk during non-AGP treatments.", "doi": "10.1111/clr.13784", "pmid": "34196047", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-07-05T14:31:00.569Z", "modified": "2021-07-05T14:31:00.690Z"}, {"entity": "publication", "iuid": "d37e5e75fe864447a97b9b63be6cab54", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d37e5e75fe864447a97b9b63be6cab54.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d37e5e75fe864447a97b9b63be6cab54"}}, "title": "ReCOV: recovery and rehabilitation during and after COVID-19 - a study protocol of a longitudinal observational study on patients, next of kin and health care staff.", "authors": [{"family": "Rydwik", "given": "E", "initials": "E", "orcid": "0000-0003-0550-1675", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03e46fbd5a7547ecb1f98245d30f3586.json"}}, {"family": "Anmyr", "given": "L", "initials": "L"}, {"family": "Regardt", "given": "M", "initials": "M"}, {"family": "McAllister", "given": "A", "initials": "A"}, {"family": "Zarenoe", "given": "R", "initials": "R"}, {"family": "\u00c5kerman", "given": "E", "initials": "E"}, {"family": "Orrevall", "given": "Y", "initials": "Y"}, {"family": "Bragesj\u00f6", "given": "M", "initials": "M"}, {"family": "Dahl", "given": "O", "initials": "O"}, {"family": "Kemani", "given": "M K", "initials": "MK"}, {"family": "Nordstrand", "given": "L", "initials": "L"}, {"family": "Ekman", "given": "U", "initials": "U"}, {"family": "Holmstr\u00f6m", "given": "L", "initials": "L"}, {"family": "Nygren-Bonnier", "given": "M", "initials": "M"}], "type": "journal article", "published": "2021-06-30", "journal": {"title": "BMC Sports Sci Med Rehabil", "issn": "2052-1847", "issn-l": null, "volume": "13", "issue": "1", "pages": "70"}, "abstract": "The knowledge of the long-term consequences of covid-19 is limited. In patients, symptoms such as fatigue, decreased physical, psychological, and cognitive function, and nutritional problems have been reported. How the disease has affected next of kin, as well as staff involved in the care of patients with covid-19, is also largely unknown. The overall aim of this study is therefore three-fold: (1) to describe and evaluate predictors of patient recovery, the type of rehabilitation received and patients' experiences of specialized rehabilitation following COVID-19 infection; (2) to study how next of kin experienced the hospital care of their relative and their experiences of the psychosocial support they received as well as their psychological wellbeing; (3) to describe experiences of caring for patients with COVID-19 and evaluate psychological wellbeing, coping mechanisms and predictors for development of psychological distress over time in health care staff.\n\nThis observational longitudinal study consists of three cohorts; patients, next of kin, and health care staff. The assessments for the patients consist of physical tests (lung function, muscle strength, physical capacity) and questionnaires (communication and swallowing, nutritional status, hearing, activities of daily living, physical activity, fatigue, cognition) longitudinally at 3, 6 and 12 months. Patient records auditing (care, rehabilitation) will be done retrospectively at 12 months. Patients (3, 6 and 12 months), next of kin (6 months) and health care staff (baseline, 3, 6, 9 and 12 months) will receive questionnaires regarding, health-related quality of life, depression, anxiety, sleeping disorders, and post-traumatic stress. Staff will also answer questionnaires about burnout and coping strategies. Interviews will be conducted in all three cohorts.\n\nThis study will be able to answer different research questions from a quantitative and qualitative perspective, by describing and evaluating long-term consequences and their associations with recovery, as well as exploring patients', next of kins' and staffs' views and experiences of the disease and its consequences. This will form a base for a deeper and better understanding of the consequences of the disease from different perspectives as well as helping the society to better prepare for a future pandemic.", "doi": "10.1186/s13102-021-00299-9", "pmid": "34193260", "labels": {"Category: Public Health": null, "Type: Journal article": null, "Category: Rehabilitation": null}, "xrefs": [{"db": "pmc", "key": "PMC8243048"}, {"db": "pii", "key": "10.1186/s13102-021-00299-9"}], "notes": [], "created": "2021-07-05T14:28:53.739Z", "modified": "2023-06-19T15:22:19.071Z"}, {"entity": "publication", "iuid": "67ce74a43c114f79ad88ccc156f49658", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/67ce74a43c114f79ad88ccc156f49658.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/67ce74a43c114f79ad88ccc156f49658"}}, "title": "Investigation of Four Clusters of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Rwanda, 2020.", "authors": [{"family": "Nsekuye", "given": "Olivier", "initials": "O"}, {"family": "Rwagasore", "given": "Edson", "initials": "E"}, {"family": "Muhimpundu", "given": "Marie Aime", "initials": "MA"}, {"family": "El-Khatib", "given": "Ziad", "initials": "Z", "orcid": "0000-0003-0756-7280", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31747e0476314de9bf53d8c8f3d1d147.json"}}, {"family": "Ntabanganyimana", "given": "Daniel", "initials": "D", "orcid": "0000-0003-2183-7873", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c49ec8a0b5e4c1e97744c1540826453.json"}}, {"family": "Kamayirese", "given": "Eric No\u00ebl", "initials": "EN"}, {"family": "Ruyange", "given": "Laurent", "initials": "L"}, {"family": "Umutoni", "given": "Angela", "initials": "A"}, {"family": "Adeline", "given": "Adeline Kabeja", "initials": "AK"}, {"family": "Ntaganira", "given": "Joseph", "initials": "J"}, {"family": "Nsazimana", "given": "Sabin", "initials": "S"}, {"family": "Omolo", "given": "Jared", "initials": "J"}], "type": "journal article", "published": "2021-06-30", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "13", "pages": "7018"}, "abstract": "We reported the findings of the first Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) four clusters identified in Rwanda. Case-investigations included contact elicitation, testing, and isolation/quarantine of confirmed cases. Socio-demographic and clinical data on cases and contacts were collected. A confirmed case was a person with laboratory confirmation of SARS-CoV-2 infection (PCR) while a contact was any person who had contact with a SARS-CoV-2 confirmed case within 72 h prior, to 14 days after symptom onset; or 14 days before collection of the laboratory-positive sample for asymptomatic cases. High risk contacts were those who had come into unprotected face-to-face contact or had been in a closed environment with a SARS-CoV-2 case for >15 min. Forty cases were reported from four clusters by 22 April 2020, accounting for 61% of locally transmitted cases within six weeks. Clusters A, B, C and D were associated with two nightclubs, one house party, and different families or households living in the same compound (multi-family dwelling). Thirty-six of the 1035 contacts tested were positive (secondary attack rate: 3.5%). Positivity rates were highest among the high-risk contacts compared to low-risk contacts (10% vs. 2.2%). Index cases in three of the clusters were imported through international travelling. Fifteen of the 40 cases (38%) were asymptomatic while 13/25 (52%) and 8/25 (32%) of symptomatic cases had a cough and fever respectively. Gatherings in closed spaces were the main early drivers of transmission. Systematic case-investigations contact tracing and testing likely contributed to the early containment of SARS-CoV-2 in Rwanda.", "doi": "10.3390/ijerph18137018", "pmid": "34209123", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8297211"}, {"db": "pii", "key": "ijerph18137018"}], "notes": [], "created": "2021-07-05T14:56:56.299Z", "modified": "2023-06-19T15:17:29.655Z"}, {"entity": "publication", "iuid": "ef958c3e559b4e04ba017e6252046903", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef958c3e559b4e04ba017e6252046903.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef958c3e559b4e04ba017e6252046903"}}, "title": "Dental care during COVID-19 pandemic: follow-up survey of experts' opinion.", "authors": [{"family": "Brunello", "given": "Giulia", "initials": "G", "orcid": "0000-0003-1436-0085", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c41e6e7b6a6d4070ba5e61aec8e085ad.json"}}, {"family": "Gurzawska-Comis", "given": "Katarzyna", "initials": "K"}, {"family": "Becker", "given": "Kathrin", "initials": "K", "orcid": "0000-0003-1936-4683", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cfa273f3515e470c87ad24540f6398f0.json"}}, {"family": "Becker", "given": "J\u00fcrgen", "initials": "J"}, {"family": "Sivolella", "given": "Stefano", "initials": "S", "orcid": "0000-0003-1916-1640", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b9d22e893e164fb2958aeff923b6fad5.json"}}, {"family": "Schwarz", "given": "Frank", "initials": "F", "orcid": "0000-0001-5515-227X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5c1fcc3c85944960a9b564494441473d.json"}}, {"family": "Klinge", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2021-06-30", "journal": {"title": "Clin Oral Implants Res", "issn": "1600-0501", "issn-l": null}, "abstract": "The purpose of the present survey is to give an update of European experts' opinion on infection control and prevention in dentistry during second wave of pandemic. The secondary aim was to analyse how experts' opinion changed in the light of the new scientific evidence since the first wave.\n\nAn anonymous online 14-item questionnaire was sent to a total of 27 leading academic experts in Oral (and Maxillofacial) Surgery from different European countries, who had completed a previous survey in April-May 2020. The questionnaire covered the topics of dental setting safety, personal protective equipment (PPE), and patient-related measures to minimise transmission risk. Data collection took place in November-February 2020/21.\n\n26 experts participated in the follow-up survey. The overall transmission risk in dental settings was scored significantly lower compared to the initial survey (P<0.05), though the risk associated with aerosol generating procedures (AGP) was still considered to be high. Maximum PPE was less frequently recommended for non-AGP (P<0.05), whereas the majority of experts still recommended FFP2/FFP3 masks (80.8%), face shields or goggles (88.5%), gowns (61.5%), and caps (57.7%) for AGP. Most of the experts also found mouth rinse relevant (73.1%) and reported to be using it prior to treatment (76.9%). No uniform opinion was found regarding the relevance of COVID-19 testing of staff and patients.\n\nWith the continuation of dental care provision, transmission risk has been scored lower compared to the first wave of pandemic. However, high risk is still assumed for AGP, and maximum PPE remained advised for the respective treatments.", "doi": "10.1111/clr.13783", "pmid": "34196051", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-07-05T14:31:22.874Z", "modified": "2021-07-05T14:31:22.956Z"}, {"entity": "publication", "iuid": "32a80056c0f2441cbd9e3bc51494ca52", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/32a80056c0f2441cbd9e3bc51494ca52.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/32a80056c0f2441cbd9e3bc51494ca52"}}, "title": "Civic Duty: A Booster for Resilience?", "authors": [{"family": "Grimm", "given": "Pauline Yongeun", "initials": "PY"}, {"family": "Saulnier", "given": "Dell D", "initials": "DD"}], "type": "editorial", "published": "2021-06-30", "journal": {"title": "Int J Public Health", "issn": "1661-8564", "volume": "66", "pages": "1604064", "issn-l": null}, "abstract": null, "doi": "10.3389/ijph.2021.1604064", "pmid": "34335149", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "1604064"}, {"db": "pmc", "key": "PMC8284586"}], "notes": [], "created": "2021-08-04T10:13:00.336Z", "modified": "2021-08-04T10:13:00.358Z"}, {"entity": "publication", "iuid": "cde11c2a5b9d4d04b30c791570e1a5f3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cde11c2a5b9d4d04b30c791570e1a5f3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cde11c2a5b9d4d04b30c791570e1a5f3"}}, "title": "Widespread Parenchymal Abnormalities and Pulmonary Embolism on Contrast-Enhanced CT Predict Disease Severity and Mortality in Hospitalized COVID-19 Patients.", "authors": [{"family": "Jalde", "given": "Francesca Campoccia", "initials": "FC"}, {"family": "Beckman", "given": "Mats O", "initials": "MO"}, {"family": "Svensson", "given": "Ann Mari", "initials": "AM"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "Sk\u00f6ld", "given": "Magnus", "initials": "M"}, {"family": "Strand", "given": "Fredrik", "initials": "F"}, {"family": "Nyren", "given": "Sven", "initials": "S"}, {"family": "Kistner", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-06-29", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "8", "pages": "666723", "issn-l": null}, "abstract": "Purpose: Severe COVID-19 is associated with inflammation, thromboembolic disease, and high mortality. We studied factors associated with fatal outcomes in consecutive COVID-19 patients examined by computed tomography pulmonary angiogram (CTPA). Methods: This retrospective, single-center cohort analysis included 130 PCR-positive patients hospitalized for COVID-19 [35 women and 95 men, median age 57 years (interquartile range 51-64)] with suspected pulmonary embolism based on clinical suspicion. The presence and extent of embolism and parenchymal abnormalities on CTPA were recorded. The severity of pulmonary parenchymal involvement was stratified by two experienced radiologists into two groups: lesions affecting \u226450% or >50% of the parenchyma. Patient characteristics, radiological aspects, laboratory parameters, and 60-day mortality data were collected. Results: Pulmonary embolism was present in 26% of the patients. Most emboli were small and peripheral. Patients with widespread parenchymal abnormalities, with or without pulmonary embolism, had increased main pulmonary artery diameter (p < 0.05) and higher C-reactive protein (p < 0.01), D-dimer (p < 0.01), and troponin T (p < 0.001) and lower hemoglobin (p < 0.001). A wider main pulmonary artery diameter correlated positively with C-reactive protein (r = 0.28, p = 0.001, and n = 130) and procalcitonin. In a multivariant analysis, D-dimer >7.2 mg/L [odds ratio (\u00b195% confidence interval) 4.1 (1.4-12.0)] and ICU stay were significantly associated with embolism (p < 0.001). The highest 60-day mortality was found in patients with widespread parenchymal abnormalities combined with pulmonary embolism (36%), followed by patients with widespread parenchymal abnormalities without pulmonary embolism (26%). In multivariate analysis, high troponin T, D-dimer, and plasma creatinine and widespread parenchymal abnormalities on CT were associated with 60-day mortality. Conclusions: Pulmonary embolism combined with widespread parenchymal abnormalities contributed to mortality risk in COVID-19. Elevated C-reactive protein, D-dimer, troponin-T, P-creatinine, and enlarged pulmonary artery were associated with a worse outcome and may mirror a more severe systemic disease. A liberal approach to radiological investigation should be recommended at clinical deterioration, when the situation allows it. Computed tomography imaging, even without intravenous contrast to assess the severity of pulmonary infiltrates, are of value to predict outcome in COVID-19. Better radiological techniques with higher resolution could potentially improve the detection of microthromboses. This could influence anticoagulant treatment strategies, preventing clinical detoriation.", "doi": "10.3389/fmed.2021.666723", "pmid": "34268322", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8275973"}], "notes": [], "created": "2021-08-06T07:16:54.586Z", "modified": "2021-08-06T07:16:54.598Z"}, {"entity": "publication", "iuid": "578ea654c3144268b705f02fc41b589b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/578ea654c3144268b705f02fc41b589b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/578ea654c3144268b705f02fc41b589b"}}, "title": "The impact of the coronavirus (COVID-19) pandemic on individuals with gastrointestinal disorders: A protocol of an international collaborative study.", "authors": [{"family": "Ferreira", "given": "Nuno", "initials": "N"}, {"family": "Mikocka-Walus", "given": "Antonina", "initials": "A"}, {"family": "van Tilburg", "given": "Miranda A L", "initials": "MAL"}, {"family": "Graff", "given": "Lesley A", "initials": "LA"}, {"family": "Apputhurai", "given": "Pragalathan", "initials": "P"}, {"family": "Acosta", "given": "Manuel Barreiro-de", "initials": "MB"}, {"family": "Evertsz", "given": "Floor Bennebroek", "initials": "FB"}, {"family": "Burisch", "given": "Johan", "initials": "J"}, {"family": "Lo", "given": "Bobby", "initials": "B"}, {"family": "Petrik", "given": "Megan", "initials": "M"}, {"family": "Trindade", "given": "In\u00eas A", "initials": "IA"}, {"family": "Jedel", "given": "Sharon", "initials": "S"}, {"family": "Moser", "given": "Gabriele", "initials": "G"}, {"family": "Mokrowiecka", "given": "Anna", "initials": "A"}, {"family": "Bernstein", "given": "Charles N", "initials": "CN"}, {"family": "Dumitrascu", "given": "Dan", "initials": "D"}, {"family": "Ford", "given": "Alexander C", "initials": "AC"}, {"family": "Stengel", "given": "Andreas", "initials": "A"}, {"family": "Gearry", "given": "Richard", "initials": "R"}, {"family": "Knowles", "given": "Simon R", "initials": "SR"}], "type": "journal article", "published": "2021-06-29", "journal": {"title": "J Psychosom Res", "issn": "1879-1360", "volume": "148", "pages": "110561", "issn-l": null}, "abstract": "The COVID-19 pandemic has had a significant impact on mental health across the globe. People living with a chronic gastrointestinal (GI) disorder might be particularly at risk of mental health complications given higher rates of comorbid anxiety and depression compared to the healthy population. As GI disorders affect up to 40% of the population worldwide, this international collaborative study seeks to evaluate the extent of the impact of the COVID-19 pandemic on GI symptoms specifically and more generally on the well-being of those living with chronic GI conditions.\n\nA longitudinal survey with three time points (baseline, 6-month, and 12-month) will be conducted online. Adult participants with GI disorders from multiple countries will be recruited via patient associations, social media advertising, utilizing snowball sampling. Participants will be invited to complete a battery of questionnaires including demographic and health parameters, and measures of gastrointestinal symptoms, fear of COVID-19, perceived impact of COVID-19, illness perceptions, coping, depression, anxiety, stress, catastrophizing, and quality of life, using validated measures where available. Statistical analyses will include univariate descriptive models, multivariate models utilizing regression, mediation, and moderation, and latent growth models.\n\nThis project may present novel information to the field of psychogastroenterology and may provide crucial information regarding the areas of impact for individuals with GI disorders during and following the pandemic. Further, this information can guide healthcare providers and patient associations on how to target support related to the pandemic mental health sequelae for these patients.", "doi": "10.1016/j.jpsychores.2021.110561", "pmid": "34217956", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0022-3999(21)00206-3"}], "notes": [], "created": "2021-07-05T15:04:38.704Z", "modified": "2021-07-05T15:06:09.736Z"}, {"entity": "publication", "iuid": "a7060bc88a5641bcaafcfe88f603e514", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7060bc88a5641bcaafcfe88f603e514.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7060bc88a5641bcaafcfe88f603e514"}}, "title": "Seeing the value of experiential knowledge through COVID-19.", "authors": [{"family": "Atkinson", "given": "Sarah", "initials": "S", "orcid": "0000-0002-7186-0644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c24c1190d314847aec131249e583e59.json"}}, {"family": "Bradby", "given": "Hannah", "initials": "H", "orcid": "0000-0002-0664-1170", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6650bd723f06404cb9f068d9bda13541.json"}}, {"family": "Gadebusch Bondio", "given": "Mariacarla", "initials": "M", "orcid": "0000-0002-5888-3059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53081b0715ff45b38f498a2fc8d3c09b.json"}}, {"family": "Hallberg", "given": "Anna", "initials": "A"}, {"family": "Macnaugthon", "given": "Jane", "initials": "J", "orcid": "0000-0002-7289-4037", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30fe568b9ecf480db633a8c576dad98d.json"}}, {"family": "S\u00f6derfeldt", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-6650-9710", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/193918c12f45489cb6cd8c949130e537.json"}}], "type": "journal article", "published": "2021-06-29", "journal": {"title": "Hist Philos Life Sci", "issn": "1742-6316", "volume": "43", "issue": "3", "pages": "85", "issn-l": null}, "abstract": "Seeing the entwinement of social and epistemic challenges through COVID, we discuss the perils of simplistic appeals to 'follow the science'. A hardened scientism risks excarbating social conflict and fueling conspiracy beliefs. Instead, we see an opportunity to devise more inclusive medical knowledge practices through endorsing experiential knowledge alongside traditional evidence types.", "doi": "10.1007/s40656-021-00438-y", "pmid": "34185187", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40656-021-00438-y"}], "notes": [], "created": "2021-06-30T04:58:23.052Z", "modified": "2021-06-30T04:58:23.181Z"}, {"entity": "publication", "iuid": "8c8581cfbe8541fc86599ac454263ffa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c8581cfbe8541fc86599ac454263ffa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c8581cfbe8541fc86599ac454263ffa"}}, "title": "Prevalence and incidence of anti-SARS-CoV-2 antibodies among healthcare workers in Belgian hospitals before vaccination: a prospective cohort study.", "authors": [{"family": "Mortgat", "given": "Laure", "initials": "L", "orcid": "0000-0002-8298-8547", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c830ab924e74a4285176040566ba96c.json"}}, {"family": "Verdonck", "given": "Kristien", "initials": "K", "orcid": "0000-0003-1153-4078", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44033acf25e24dfb945b0c6300d2be4f.json"}}, {"family": "Hutse", "given": "Veronik", "initials": "V"}, {"family": "Thomas", "given": "Isabelle", "initials": "I"}, {"family": "Barbezange", "given": "Cyril", "initials": "C"}, {"family": "Heyndrickx", "given": "Leo", "initials": "L"}, {"family": "Fischer", "given": "Natalie", "initials": "N"}, {"family": "Vuylsteke", "given": "Bea", "initials": "B"}, {"family": "Kabouche", "given": "Ines", "initials": "I"}, {"family": "Ari\u00ebn", "given": "Kevin K", "initials": "KK"}, {"family": "Desombere", "given": "Isabelle", "initials": "I"}, {"family": "Duysburgh", "given": "Els", "initials": "E"}], "type": "journal article", "published": "2021-06-29", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "6", "pages": "e050824", "issn-l": "2044-6055"}, "abstract": "To describe prevalence and incidence of anti-SARS-CoV-2 antibodies among Belgian hospital healthcare workers (HCW) in April-December 2020.\n\nProspective cohort study. Follow-up was originally planned until September and later extended.\n\nMulticentre study, 17 hospitals.\n\n50 HCW were randomly selected per hospital. HCW employed beyond the end of the study and whose profession involved contact with patients were eligible. 850 HCW entered the study in April-May 2020, 673 HCW (79%) attended the September visit and 308 (36%) the December visit.\n\nA semiquantitative ELISA was used to detect IgG against SARS-CoV-2 in serum (Euroimmun) at 10 time points. In seropositive samples, neutralising antibodies were measured using a virus neutralisation test. Real-time reverse transcription PCR (RT-qPCR) was performed to detect SARS-CoV-2 on nasopharyngeal swabs. Participant characteristics and the presence of symptoms were collected via an online questionnaire.\n\nAmong all participants, 80% were women, 60% nurses and 21% physicians. Median age was 40 years. The seroprevalence remained relatively stable from April (7.7% (95% CI: 4.8% to 12.1%) to September (8.2% (95% CI: 5.7% to 11.6%)) and increased thereafter, reaching 19.7% (95% CI: 12.0% to 30.6%) in December 2020. 76 of 778 initially seronegative participants seroconverted during the follow-up (incidence: 205/1000 person-years). Among all seropositive individuals, 118/148 (80%) had a positive neutralisation test, 83/147 (56%) presented or reported a positive RT-qPCR, and 130/147 (88%) reported COVID-19-compatible symptoms at least once. However, only 46/73 (63%) of the seroconverters presented COVID-19-compatible symptoms in the month prior to seroconversion.\n\nThe seroprevalence among hospital HCW was slightly higher than that of the general Belgian population but followed a similar evolution, suggesting that infection prevention and control measures were effective and should be strictly maintained. After two SARS-CoV-2 waves, 80% of HCW remained seronegative, justifying their prioritisation in the vaccination strategy.\n\nNCT04373889.", "doi": "10.1136/bmjopen-2021-050824", "pmid": "34187832", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2021-050824"}, {"db": "pmc", "key": "PMC8245288"}, {"db": "ClinicalTrials.gov", "key": "NCT04373889"}], "notes": [], "created": "2021-07-05T14:23:22.273Z", "modified": "2021-07-05T14:23:22.338Z"}, {"entity": "publication", "iuid": "9eb01593d4c547d7823b006e981ce6fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9eb01593d4c547d7823b006e981ce6fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9eb01593d4c547d7823b006e981ce6fc"}}, "title": "Combined Metabolic Activators Accelerates Recovery in Mild\u2010to\u2010Moderate COVID\u201019", "authors": [{"family": "Altay", "given": "Ozlem", "initials": "O"}, {"family": "Arif", "given": "Muhammad", "initials": "M"}, {"family": "Li", "given": "Xiangyu", "initials": "X"}, {"family": "Yang", "given": "Hong", "initials": "H"}, {"family": "Ayd\u0131n", "given": "Mehtap", "initials": "M"}, {"family": "Alkurt", "given": "Gizem", "initials": "G"}, {"family": "Kim", "given": "Woonghee", "initials": "W"}, {"family": "Akyol", "given": "Dogukan", "initials": "D"}, {"family": "Zhang", "given": "Cheng", "initials": "C"}, {"family": "Dinler\u2010Doganay", "given": "Gizem", "initials": "G"}, {"family": "Turkez", "given": "Hasan", "initials": "H"}, {"family": "Shoaie", "given": "Saeed", "initials": "S"}, {"family": "Nielsen", "given": "Jens", "initials": "J"}, {"family": "Bor\u00e9n", "given": "Jan", "initials": "J"}, {"family": "Olmuscelik", "given": "Oktay", "initials": "O"}, {"family": "Doganay", "given": "Levent", "initials": "L"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A"}], "type": "journal-article", "published": "2021-06-28", "journal": {"title": "Adv. Sci.", "issn": "2198-3844", "issn-l": null, "volume": null, "issue": null, "pages": "2101222"}, "abstract": null, "doi": "10.1002/advs.202101222", "pmid": null, "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.1002/advs.202101222", "description": "Raw, patient-level characteristics and data"}], "notes": [], "created": "2021-06-28T18:03:41.425Z", "modified": "2021-07-06T09:30:30.964Z"}, {"entity": "publication", "iuid": "886c0b7aa006483ebf152b73ed4aab93", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/886c0b7aa006483ebf152b73ed4aab93.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/886c0b7aa006483ebf152b73ed4aab93"}}, "title": "Case Report: Systemic Sclerosis After Covid-19 Infection.", "authors": [{"family": "Fineschi", "given": "Serena", "initials": "S"}], "type": "case reports", "published": "2021-06-28", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "12", "pages": "686699", "issn-l": "1664-3224"}, "abstract": "The coronavirus disease (COVID-19) is a respiratory tract infection caused by the new virus SARS-CoV-2. The acute phase of the infection may in certain individuals be followed by another longer phase of disease (long COVID) of unknown etiology probably associated in certain cases with autoimmune activation. It has been shown that COVID-19 can trigger autoantibody production and in genetically predisposed patients may cause the onset or exacerbation of autoimmune diseases. We are reporting a case of mild COVID-19 infection complicated by autoantibody production and cutaneous and gastrointestinal symptoms and subsequently diagnosed with systemic sclerosis (SSc). A 47-year-old man with no history of any autoimmune diseases and in good health became sick together with his family on the 12th of November with mild symptoms: tiredness, fever, cough, and sore throat. Oropharyngeal swab for SARS-CoV-2 tested positive. He was isolated at home and did not require hospitalization. Three weeks later he presented with clinical manifestation compatible with suspicion of SSc. He briefly presented with skin rush, periorbital edema and conjunctivitis, vomiting, dysphagia, burning sensation in the skin, above all in the fingertips and around the mouth, puffy fingers, Raynaud's phenomenon, pain at the fingertip of the middle finger where a depressed area was noticed without a clear ulceration. ANA showed a strongly positive nucleolar pattern. Anti-PM/Scl 75 and PM/Scl 100 resulted positive. High-resolution computed tomography (HCRT) showed early stage of interstitial lung disease (ILD). The patient was diagnosed with SSc based on the persistence of autoantibodies and the clinical and radiological pictures according to the ACR/EULAR classification (scores: puffy finger, 2; ILD, 2; Raynaud's phenomenon, 3; SSc related antibodies, 3; total 10). There are several cases described in the medical literature of possible new onset of SLE after COVID-19 infection. This is the first case that describes a possible new onset of SSc. Conclusion: SARS-CoV-2 may trigger systemic sclerosis.", "doi": "10.3389/fimmu.2021.686699", "pmid": "34262566", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8273695"}], "notes": [], "created": "2021-08-06T07:17:58.171Z", "modified": "2021-08-06T07:18:53.884Z"}, {"entity": "publication", "iuid": "fb6a3ca888ca4cedbbc1e13a3fed36be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb6a3ca888ca4cedbbc1e13a3fed36be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb6a3ca888ca4cedbbc1e13a3fed36be"}}, "title": "A review and agenda for integrated disease models including social and behavioural factors.", "authors": [{"family": "Bedson", "given": "Jamie", "initials": "J"}, {"family": "Skrip", "given": "Laura A", "initials": "LA"}, {"family": "Pedi", "given": "Danielle", "initials": "D"}, {"family": "Abramowitz", "given": "Sharon", "initials": "S", "orcid": "0000-0003-3671-8842", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6bd9191aa8464bb58424225e812d761c.json"}}, {"family": "Carter", "given": "Simone", "initials": "S", "orcid": "0000-0003-3818-3538", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/227e9d375a6649df95425a287f069f01.json"}}, {"family": "Jalloh", "given": "Mohamed F", "initials": "MF"}, {"family": "Funk", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-2842-3406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f03dcbc41884648a4eac5892852899a.json"}}, {"family": "Gobat", "given": "Nina", "initials": "N", "orcid": "0000-0002-1558-557X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78a857e67488494caced727f69c370cf.json"}}, {"family": "Giles-Vernick", "given": "Tamara", "initials": "T", "orcid": "0000-0003-2873-8544", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a47231b81c92440da0d4fdc91b79c108.json"}}, {"family": "Chowell", "given": "Gerardo", "initials": "G"}, {"family": "de Almeida", "given": "Jo\u00e3o Rangel", "initials": "JR", "orcid": "0000-0002-8533-7942", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e0727d3e3ab411987c0dee3120dd1e1.json"}}, {"family": "Elessawi", "given": "Rania", "initials": "R"}, {"family": "Scarpino", "given": "Samuel V", "initials": "SV"}, {"family": "Hammond", "given": "Ross A", "initials": "RA"}, {"family": "Briand", "given": "Sylvie", "initials": "S"}, {"family": "Epstein", "given": "Joshua M", "initials": "JM"}, {"family": "H\u00e9bert-Dufresne", "given": "Laurent", "initials": "L", "orcid": "0000-0002-0008-3673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d7de71d9cc94861a3e846ff6e2ec221.json"}}, {"family": "Althouse", "given": "Benjamin M", "initials": "BM", "orcid": "0000-0002-5464-654X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90d8ce24f2004d148411bb922f38c418.json"}}], "type": "journal article", "published": "2021-06-28", "journal": {"title": "Nat Hum Behav", "issn": "2397-3374", "issn-l": "2397-3374"}, "abstract": "Social and behavioural factors are critical to the emergence, spread and containment of human disease, and are key determinants of the course, duration and outcomes of disease outbreaks. Recent epidemics of Ebola in West Africa and coronavirus disease 2019 (COVID-19) globally have reinforced the importance of developing infectious disease models that better integrate social and behavioural dynamics and theories. Meanwhile, the growth in capacity, coordination and prioritization of social science research and of risk communication and community engagement (RCCE) practice within the current pandemic response provides an opportunity for collaboration among epidemiological modellers, social scientists and RCCE practitioners towards a mutually beneficial research and practice agenda. Here, we provide a review of the current modelling methodologies and describe the challenges and opportunities for integrating them with social science research and RCCE practice. Finally, we set out an agenda for advancing transdisciplinary collaboration for integrated disease modelling and for more robust policy and practice for reducing disease transmission.", "doi": "10.1038/s41562-021-01136-2", "pmid": "34183799", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41562-021-01136-2"}], "notes": [], "created": "2021-06-30T04:58:04.398Z", "modified": "2021-06-30T04:58:04.584Z"}, {"entity": "publication", "iuid": "c810a662405f412a878a8c0e624c3bfb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c810a662405f412a878a8c0e624c3bfb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c810a662405f412a878a8c0e624c3bfb"}}, "title": "Psychological Determinants of COVID-19 Vaccine Acceptance among Healthcare Workers in Kuwait: A Cross-Sectional Study Using the 5C and Vaccine Conspiracy Beliefs Scales.", "authors": [{"family": "Al-Sanafi", "given": "Mariam", "initials": "M"}, {"family": "Sallam", "given": "Malik", "initials": "M"}], "type": "journal article", "published": "2021-06-25", "journal": {"title": "Vaccines", "issn": "2076-393X", "issn-l": null, "volume": "9", "issue": "7", "pages": null}, "abstract": "Acceptance of coronavirus disease 2019 (COVID-19) vaccination appears as a decisive factor necessary to control the ongoing pandemic. Healthcare workers (HCWs) are among the highest risk groups for infection. The current study aimed to evaluate COVID-19 vaccine acceptance among HCWs in Kuwait, with identification of the psychological determinants of COVID-19 vaccine hesitancy. The study was conducted using an online anonymous survey distributed between 18 March 2021 and 29 March 2021. The sampling strategy was convenience-based depending on chain-referral sampling. Psychological determinants of COVID-19 vaccine acceptance were assessed using the 5C subscales and the Vaccine Conspiracy Beliefs Scale (VCBS). The total number of study participants was 1019, with the largest group being physicians (28.7%), pharmacists (20.2%), dentists (16.7%), and nurses (12.5%). The overall rate for COVID-19 vaccine acceptance was 83.3%, with 9.0% who were not willing to accept vaccination and 7.7% who were unsure. The highest rate for COVID-19 vaccine acceptance was seen among dentists (91.2%) and physicians (90.4%), while the lowest rate was seen among nurses (70.1%; p < 0.001). A higher level of COVID-19 vaccine hesitancy was found among females, participants with a lower educational level, and HCWs in the private sector. A preference for mRNA vaccine technology and Pfizer-BioNTech COVID-19 vaccine was found among the majority of participants (62.6% and 69.7%, respectively). COVID-19 vaccine hesitancy was significantly linked to the embrace of vaccine conspiracy beliefs. The highest 5C psychological predictors of COVID-19 vaccine acceptance were high levels of collective responsibility and confidence, and lower levels of constraints and calculation. The VCBS and 5C subscales (except the calculation subscale) showed acceptable levels of predicting COVID-19 vaccine acceptance based on receiver operating characteristic analyses. The participants who depended on social media platforms, TV programs, and news releases as their main sources of knowledge about COVID-19 vaccines showed higher rates of COVID-19 vaccine hesitancy. An overall satisfactory level of COVID-19 vaccine acceptance was seen among HCWs in Kuwait, which was among the highest rates reported globally. However; higher levels of vaccine hesitancy were observed among certain groups (females, nurses and laboratory workers, HCWs in the private sector), which should be targeted with more focused awareness programs. HCWs in Kuwait can play a central role in educating their patients and the general public about the benefits of COVID-19 vaccination to halt the spread of SARS-CoV-2, considering the high rates of vaccine hesitancy observed among the general public in Kuwait and the Middle East.", "doi": "10.3390/vaccines9070701", "pmid": "34202298", "labels": {"Category: Public Health": null, "Type: Review": null}, "xrefs": [{"db": "pii", "key": "vaccines9070701"}], "notes": [], "created": "2021-07-05T14:33:44.839Z", "modified": "2021-07-14T11:17:15.465Z"}, {"entity": "publication", "iuid": "16fd40dde240457d8dbea892eeff3089", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16fd40dde240457d8dbea892eeff3089.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16fd40dde240457d8dbea892eeff3089"}}, "title": "Nuclear factor-kappa B and its role in inflammatory lung disease.", "authors": [{"family": "Alharbi", "given": "Khalid Saad", "initials": "KS"}, {"family": "Fuloria", "given": "Neeraj Kumar", "initials": "NK"}, {"family": "Fuloria", "given": "Shivkanya", "initials": "S"}, {"family": "Rahman", "given": "Sk Batin", "initials": "SB"}, {"family": "Al-Malki", "given": "Waleed Hassan", "initials": "WH"}, {"family": "Javed Shaikh", "given": "Mohammad Arshad", "initials": "MA"}, {"family": "Thangavelu", "given": "Lakshmi", "initials": "L"}, {"family": "Singh", "given": "Sachin K", "initials": "SK"}, {"family": "Rama Raju", "given": "Venkata Sita", "initials": "VS"}, {"family": "Jha", "given": "Niraj Kumar", "initials": "NK"}, {"family": "Chellappan", "given": "Dinesh Kumar", "initials": "DK"}, {"family": "Dua", "given": "Kamal", "initials": "K"}, {"family": "Gupta", "given": "Gaurav", "initials": "G"}], "type": "journal article", "published": "2021-06-25", "journal": {"title": "Chem Biol Interact", "issn": "1872-7786", "pages": "109568", "issn-l": null}, "abstract": "Nuclear factor-kappa B, involved in inflammation, host immune response, cell adhesion, growth signals, cell proliferation, cell differentiation, and apoptosis defense, is a dimeric transcription factor. Inflammation is a key component of many common respiratory disorders, including asthma, COPD, bronchiectasis, and acute respiratory distress syndrome. Many basic transcription factors are found in NF-\u03baB, which is a member of the Rel protein family. Five members of this family c-REL, NF-\u03baB2 (p100/p52), RelA (p65), NF-\u03baB1 (p105/p50), RelB, and RelA (p65) produce 5 transcriptionally active molecules. Proinflammatory cytokines, T lymphocyte, and B lymphocyte cell mitogens, lipopolysaccharides, bacteria, viral proteins, viruses, double-stranded RNA, oxidative stress, physical exertion, various chemotherapeutics are the stimulus responsible for NF-\u03baB activation. NF-\u03baB act as a principal component for several common respiratory illnesses, such as asthma, lung cancer, pulmonary fibrosis, COPD as well as infectious diseases like pneumonia, tuberculosis, COVID-19. Inflammatory lung disease, especially COVID-19, can make NF-\u03baB a key target for drug production.", "doi": "10.1016/j.cbi.2021.109568", "pmid": "34181887", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0009-2797(21)00206-4"}], "notes": [], "created": "2021-06-30T04:57:33.760Z", "modified": "2021-06-30T04:57:44.179Z"}, {"entity": "publication", "iuid": "352d0e4195ea4501abf1525b7513be07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/352d0e4195ea4501abf1525b7513be07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/352d0e4195ea4501abf1525b7513be07"}}, "title": "Lifestyle changes during the first wave of the COVID-19 pandemic: a cross-sectional survey in the Netherlands.", "authors": [{"family": "van der Werf", "given": "Esther T", "initials": "ET"}, {"family": "Busch", "given": "Martine", "initials": "M"}, {"family": "Jong", "given": "Miek C", "initials": "MC"}, {"family": "Hoenders", "given": "H J Rogier", "initials": "HJR"}], "type": "journal article", "published": "2021-06-25", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "1226"}, "abstract": "During the Covid-19 pandemic the Dutch government implemented its so-called 'intelligent lockdown' in which people were urged to leave their homes as little as possible and work from home. This life changing event may have caused changes in lifestyle behaviour, an important factor in the onset and course of diseases. The overarching aim of this study is to determine life-style related changes during the first wave of the COVID-19 pandemic among a representative sample of the adult population in the Netherlands.\r\n\r\nLife-style related changes were studied among a random representative sample of the adult population in the Netherlands using an online survey conducted from 22 to 27 May 2020. Differences in COVID-19-related lifestyle changes between Complementary and Alternative Medicine (CAM) users and non-CAM users were determined. The survey included a modified version of the I-CAM-Q and 26 questions on lifestyle related measures, anxiety, and need for support to maintain lifestyle changes.\r\n\r\n1004 respondents were included in the study, aged between 18 and 88 years (50.7% females). Changes to a healthier lifestyle were observed in 19.3% of the population, mainly due to a change in diet habits, physical activity and relaxation, of whom 56.2% reported to be motivated to maintain this behaviour change in a post-COVID-19 era. Fewer respondents (12.3%) changed into an unhealthier lifestyle. Multivariable logistic regression analyses revealed that changing into a healthier lifestyle was positively associated with the variables 'Worried/Anxious getting COVID-19' (OR: 1.56, 95% C.I. 1.26-1.93), 'CAM use' (OR: 2.04, 95% C.I. 1.38-3.02) and 'stress in relation to financial situation' (OR: 1.89, 95% C.I. 1.30-2.74). 'Age' (OR 18-25: 1.00, OR 25-40: 0.55, 95% C.I. 0.31-0.96, OR 40-55:0.50 95% C.I. 0.28-0.87 OR 55+: 0.1095% C.I. 0.10-0.33), 'stress in relation to health' (OR: 2.52, 95% C.I. 1.64-3.86) and 'stress in relation to the balance work and home' (OR: 1.69, 95% C.I. 1.11-2.57) were found predicting the change into an unhealthier direction.\r\n\r\nThese findings suggest that the coronavirus crisis resulted in a healthier lifestyle in one part and, to a lesser extent, in an unhealthier lifestyle in another part of the Dutch population. Further studies are warranted to see whether this behavioural change is maintained over time, and how different lifestyle factors can affect the susceptibility for and the course of COVID-19.", "doi": "10.1186/s12889-021-11264-z", "pmid": "34172042", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11264-z"}], "notes": [], "created": "2021-06-28T18:11:12.503Z", "modified": "2021-07-14T11:18:29.701Z"}, {"entity": "publication", "iuid": "6aa9df86d6284fd6815f332f6cf4d361", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6aa9df86d6284fd6815f332f6cf4d361.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6aa9df86d6284fd6815f332f6cf4d361"}}, "title": "Extended theory of planned behavior in explaining the intention to COVID-19 vaccination uptake among mainland Chinese university students: an online survey study", "authors": [{"family": "Fan", "given": "Chia Wei", "initials": "CW"}, {"family": "Chen", "given": "I Hua", "initials": "IH", "orcid": "0000-0001-6999-6406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/832b240d9a32490da7c16ec117cf5dbf.json"}}, {"family": "Ko", "given": "Nai Ying", "initials": "NY", "orcid": "0000-0002-3007-2537", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bcdd2c7f1bf84efb9c8b95bcb498c8cb.json"}}, {"family": "Yen", "given": "Cheng Fang", "initials": "CF"}, {"family": "Lin", "given": "Chung Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal-article", "published": "2021-06-25", "journal": {"title": "Human Vaccines & Immunotherapeutics", "issn": "2164-5515", "pages": "1-8", "issn-l": null}, "abstract": null, "doi": "10.1080/21645515.2021.1933687", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:12:19.308Z", "modified": "2021-06-28T18:12:19.466Z"}, {"entity": "publication", "iuid": "2e957843514442c6a758bf3ed5620021", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e957843514442c6a758bf3ed5620021.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e957843514442c6a758bf3ed5620021"}}, "title": "COVID-19 Transmission due to Mass Mobility Before and After the Largest Festival in Bangladesh: An Epidemiologic Study.", "authors": [{"family": "Rahman", "given": "Farah Naz", "initials": "FN"}, {"family": "Rahman", "given": "A K M Fazlur", "initials": "AKMF"}, {"family": "Iwuagwu", "given": "Anthony Obinna", "initials": "AO"}, {"family": "Dalal", "given": "Koustuv", "initials": "K"}], "type": "journal article", "published": "2021-06-25", "journal": {"title": "Inquiry", "issn": "1945-7243", "issn-l": null, "volume": "58", "issue": null, "pages": "469580211023464"}, "abstract": "Festivals traditionally result in mass public mobility from large cities to rural or semi-urban areas in low- and middle-Income Countries (LMIC), which are inadequately prepared for tackling the consequences of the COVID-19 pandemic. This study aimed to explore the trend of COVID-19 infection in a peripheral region of Bangladesh during one of the largest festivals to develop an evidence-based hypothesis for its influence on the transmission rate of COVID-19. This study conducted a quantitative analysis of secondary data on COVID-19 collected from the Directorate General of Health Services Bangladesh (DGHS) and divisional director's office in the Mymensingh division. To explore the influence of one of the biggest festivals (Eid-ul-Adha) on the trend of COVID-19 infection, we analyzed data from a week before the festival to 2 weeks following the festival. The infection rate (positive cases per million of the population) and the test positivity rate (positive cases among the total number of conducted diagnostic tests) of each day during this period were calculated both for the Mymensingh region and national level. Both the test positivity rate (TPR) and infection rates in the Mymensingh region demonstrated an increasing trend. The mean test positivity rate of the Mymensingh region on the week before the festival was 9.5%. It increased to a mean test positivity rate of 13% in the following week and further rose to a rate of 17% in the next week. The infection rate of Mymensingh also increased more than 2 folds from the day of the festival (2.0-5.3 cases per million) within the next 2 weeks. The TPR and infection rate on the national level remained similar throughout the study period. Mass mobility during Eid-ul-Adha influences the increased transmission of COVID-19 among the peripheral regions of Bangladesh from the central capital city Dhaka. The findings will help policymakers plan and implement travel restrictions during festivals during the pandemic in LMICs.", "doi": "10.1177/00469580211023464", "pmid": "34166134", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:15:05.881Z", "modified": "2021-07-14T11:19:15.484Z"}, {"entity": "publication", "iuid": "234fc3388f0546a9a405eafcba15f5bb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/234fc3388f0546a9a405eafcba15f5bb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/234fc3388f0546a9a405eafcba15f5bb"}}, "title": "Suggested treatment of serious complications to Covid\u201019 vaccination with IdeS, a bacterial antibody\u2010cleaving enzyme", "authors": [{"family": "Kahn", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-5566-6350", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42eda71f3775400599febc10a4e7359c.json"}}, {"family": "Shannon", "given": "Oonagh", "initials": "O", "orcid": "0000-0001-8291-8189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7fad6031e2f4a84a8ede77911d3c542.json"}}, {"family": "Bj\u00f6rck", "given": "Lars", "initials": "L"}], "type": "journal-article", "published": "2021-06-24", "journal": {"title": "J Thromb Haemost", "issn": "1538-7836", "issn-l": null}, "abstract": null, "doi": "10.1111/jth.15433", "pmid": null, "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:15:49.076Z", "modified": "2021-06-30T05:08:56.397Z"}, {"entity": "publication", "iuid": "0ac0332baa1f45c4aa00387bcc5c8b14", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ac0332baa1f45c4aa00387bcc5c8b14.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ac0332baa1f45c4aa00387bcc5c8b14"}}, "title": "Risk of SARS-CoV-2 infection and subsequent hospital admission and death at different time intervals since first dose of COVID-19 vaccine administration, Italy, 27 December 2020 to mid-April 2021", "authors": [{"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Spila Alegiani", "given": "Stefania", "initials": "S"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Filia", "given": "Antonietta", "initials": "A"}, {"family": "Massari", "given": "Marco", "initials": "M"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Tallon", "given": "Marco", "initials": "M"}, {"family": "Proietti", "given": "Valeria", "initials": "V"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Puopolo", "given": "Maria", "initials": "M"}, {"family": "Spuri", "given": "Matteo", "initials": "M"}, {"family": "Morciano", "given": "Cristina", "initials": "C"}, {"family": "D\u2019Ancona", "given": "Fortunato (Paolo)", "initials": "F("}, {"family": "Da Cas", "given": "Roberto", "initials": "R"}, {"family": "Battilomo", "given": "Serena", "initials": "S"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Menniti-Ippolito", "given": "Francesca", "initials": "F"}, {"family": "None", "given": "", "initials": ""}, {"family": "None", "given": "", "initials": ""}], "type": "journal-article", "published": "2021-06-24", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "25", "pages": null}, "abstract": null, "doi": "10.2807/1560-7917.es.2021.26.25.2100507", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:13:29.956Z", "modified": "2021-07-14T11:16:12.655Z"}, {"entity": "publication", "iuid": "16fa3d7c7cdc4a339271cff87092d7c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16fa3d7c7cdc4a339271cff87092d7c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16fa3d7c7cdc4a339271cff87092d7c0"}}, "title": "Evolution, Correlation, Structural Impact and Dynamics of Emerging SARS-CoV-2 Variants.", "authors": [{"family": "Spratt", "given": "Austin N", "initials": "AN"}, {"family": "Kannan", "given": "Saathvik R", "initials": "SR"}, {"family": "Woods", "given": "Lucas T", "initials": "LT"}, {"family": "Weisman", "given": "Gary A", "initials": "GA"}, {"family": "Quinn", "given": "Thomas P", "initials": "TP"}, {"family": "Lorson", "given": "Christian L", "initials": "CL"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}, {"family": "Singh", "given": "Kamal", "initials": "K"}], "type": "journal article", "published": "2021-06-24", "journal": {"title": "Comput Struct Biotechnol J", "issn": "2001-0370", "issn-l": "2001-0370"}, "abstract": "Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infections remain unmanageable in some parts of the world. As with other RNA viruses, mutations in the SARS-CoV-2 gene have been continuously evolving. Recently, four variants have been identified, B.1.1.7, B.1.351, P.1 and CAL.20C. These variants appear to be more infectious and transmissible than the original Wuhan-Hu-1 virus. Using a combination of bioinformatics and structural analyses, we show that the new SARS-CoV-2 variants emerged in the background of an already known Spike protein mutation D614G together with another mutation P323L in the RNA polymerase of SARS-CoV-2. The phylogenetic analysis showed that the CAL.20C and B.1.351 shared one common ancestor, whereas the B.1.1.7 and P.1 shared a different ancestor. Structural comparisons did not show any significant difference between the wild-type and mutant ACE2/Spike complexes. Structural analysis indicated that the N501Y mutation may increase hydrophobic interactions at the ACE2/Spike interface. However, reported greater binding affinity of N501Y Spike with ACE2 does not seem to be entirely due to increased hydrophobic interactions, given that Spike mutation R417T in P.1 or K417N in B.1.351 results in the loss of a salt-bridge interaction between ACE2 and S-RBD. The calculated change in free energy did not provide a clear trend of S protein stability of mutations in the variants. As expected, we show that the CAL.20C generally migrated from the west coast to the east coast of the USA. Taken together, the analyses suggest that the evolution of variants and their infectivity is complex and may depend upon many factors.", "doi": "10.1016/j.csbj.2021.06.037", "pmid": "34188776", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2001-0370(21)00275-0"}, {"db": "pmc", "key": "PMC8225291"}], "notes": [], "created": "2021-07-05T14:24:05.957Z", "modified": "2021-07-05T14:24:05.969Z"}, {"entity": "publication", "iuid": "b8075ce5a3464e22a6ce2f9b1cfdc626", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8075ce5a3464e22a6ce2f9b1cfdc626.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8075ce5a3464e22a6ce2f9b1cfdc626"}}, "title": "Detection and viral RNA shedding of SARS-CoV-2 in respiratory specimens relative to symptom onset among COVID-19 patients in Bavaria, Germany.", "authors": [{"family": "Woudenberg", "given": "Tom", "initials": "T", "orcid": "0000-0002-5675-7470", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9992ee28624349caaa1984823c705bf4.json"}}, {"family": "Eberle", "given": "Ute", "initials": "U"}, {"family": "Marosevic", "given": "Durdica", "initials": "D"}, {"family": "Liebl", "given": "Bernhard", "initials": "B"}, {"family": "Ackermann", "given": "Nikolaus", "initials": "N"}, {"family": "Katz", "given": "Katharina", "initials": "K"}, {"family": "Sing", "given": "Andreas", "initials": "A", "orcid": "0000-0003-1619-6047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3be5645dc94443809ebedaef2961294a.json"}}, {"family": "Bavarian SARS-CoV-2-Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-06-23", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "issn-l": null, "volume": "149", "issue": null, "pages": "e150"}, "abstract": "We assessed severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) reverse transcriptase-polymerase chain reaction (RT-PCR) diagnostic sensitivity and cycle threshold (Ct) values relative to symptom onset in symptomatic coronavirus disease-2019 (COVID-19) patients from Bavaria, Germany, of whom a subset was repeatedly tested. Locally weighted scatterplot smoothing method was used to assess the relationship between symptom onset and Ct-values. Kaplan-Meier plots were used to visualise the empirical probability of detecting viral ribonucleic acid (RNA) over time and estimate the time until clearance of viral RNA among the repeatedly tested patients. Among 721 reported COVID-19 cases, the viral RNA was detected in specimens taken between three days before and up to 48 days after symptom onset. The mean Ct-value was 28.6 (95% confidence interval (CI) 28.2-29.0) with the lowest mean Ct-value (26.2) observed two days after symptom onset. Up to 7 days after symptom onset, the diagnostic sensitivity of the RT-PCR among repeatedly sampled patients (n = 208) remained above 90% and decreased to 50% at day 12 (95% CI 10.5-21.5). Our data provide valuable estimates to optimise the timing of sampling of individuals for SARS-CoV-2 detection. A considerable proportion of specimens sampled before symptom onset had Ct-values comparable with Ct-values after symptom onset, suggesting the probability of presymptomatic transmission.", "doi": "10.1017/S0950268821001345", "pmid": "34158139", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8314058"}, {"db": "pii", "key": "S0950268821001345"}], "notes": [], "created": "2021-06-28T18:18:35.200Z", "modified": "2023-06-19T15:23:52.921Z"}, {"entity": "publication", "iuid": "66f436ea105e4dd29af69fbafc5e18c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66f436ea105e4dd29af69fbafc5e18c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66f436ea105e4dd29af69fbafc5e18c5"}}, "title": "COVseq is a cost-effective workflow for mass-scale SARS-CoV-2 genomic surveillance.", "authors": [{"family": "Simonetti", "given": "Michele", "initials": "M", "orcid": "0000-0003-3322-1697", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1382a34459c64b839f1d7889625c374c.json"}}, {"family": "Zhang", "given": "Ning", "initials": "N", "orcid": "0000-0002-6430-4236", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/866db18024634b20af9872a97c716be2.json"}}, {"family": "Harbers", "given": "Luuk", "initials": "L", "orcid": "0000-0003-3910-6497", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2f9ea2325db4f6fab536fe923f90bf3.json"}}, {"family": "Milia", "given": "Maria Grazia", "initials": "MG"}, {"family": "Brossa", "given": "Silvia", "initials": "S"}, {"family": "Huong Nguyen", "given": "Thi Thu", "initials": "TT", "orcid": "0000-0002-9089-7370", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b366997bbc1645828d0ea10cc1c8ad0e.json"}}, {"family": "Cerutti", "given": "Francesco", "initials": "F", "orcid": "0000-0003-0480-8296", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05159eca599748f6b79857bb726200c1.json"}}, {"family": "Berrino", "given": "Enrico", "initials": "E"}, {"family": "Sapino", "given": "Anna", "initials": "A"}, {"family": "Bienko", "given": "Magda", "initials": "M", "orcid": "0000-0002-6499-9082", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa0cd262fa184872b92d7589a2cc2d62.json"}}, {"family": "Sottile", "given": "Antonino", "initials": "A"}, {"family": "Ghisetti", "given": "Valeria", "initials": "V", "orcid": "0000-0002-4698-598X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3aebeae45cb44e4691c4d3fc468f8699.json"}}, {"family": "Crosetto", "given": "Nicola", "initials": "N", "orcid": "0000-0002-3019-6978", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc7960c369064c89a193bd94b598d12d.json"}}], "type": "journal article", "published": "2021-06-23", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "3903"}, "abstract": "While mass-scale vaccination campaigns are ongoing worldwide, genomic surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to monitor the emergence and global spread of viral variants of concern (VOC). Here, we present a streamlined workflow-COVseq-which can be used to generate highly multiplexed sequencing libraries compatible with Illumina platforms from hundreds of SARS-CoV-2 samples in parallel, in a rapid and cost-effective manner. We benchmark COVseq against a standard library preparation method (NEBNext) on 29 SARS-CoV-2 positive samples, reaching 95.4% of concordance between single-nucleotide variants detected by both methods. Application of COVseq to 245 additional SARS-CoV-2 positive samples demonstrates the ability of the method to reliably detect emergent VOC as well as its compatibility with downstream phylogenetic analyses. A cost analysis shows that COVseq could be used to sequence thousands of samples at less than 15 USD per sample, including library preparation and sequencing costs. We conclude that COVseq is a versatile and scalable method that is immediately applicable for SARS-CoV-2 genomic surveillance and easily adaptable to other pathogens such as influenza viruses.", "doi": "10.1038/s41467-021-24078-9", "pmid": "34162869", "labels": {"Research Area: Viral sequence evolution": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-24078-9"}, {"db": "pmc", "key": "PMC8222401"}], "notes": [], "created": "2021-06-23T11:59:06.941Z", "modified": "2021-12-11T05:55:57.605Z"}, {"entity": "publication", "iuid": "be10034a6b7e4a398b1da679f17fedba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be10034a6b7e4a398b1da679f17fedba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be10034a6b7e4a398b1da679f17fedba"}}, "title": "Who should be tested in a pandemic? Ethical considerations.", "authors": [{"family": "Hansson", "given": "Sven Ove", "initials": "SO", "orcid": "0000-0003-0071-3919", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44c820ae26d9495684ea585732835a69.json"}}, {"family": "Helgesson", "given": "Gert", "initials": "G"}, {"family": "Juth", "given": "Niklas", "initials": "N"}], "type": "journal article", "published": "2021-06-22", "journal": {"title": "BMC Med Ethics", "issn": "1472-6939", "volume": "22", "issue": "1", "pages": "76", "issn-l": null}, "abstract": "In the initial phase of the Covid-19 pandemic, difficult decisions had to be made on the allocation of testing resources. Similar situations can arise in future pandemics. Therefore, careful consideration of who should be tested is an important part of pandemic preparedness. We focus on four ethical aspects of that problem: how to prioritize scarce testing resources, the regulation of commercial direct-to-consumer test services, testing of unauthorized immigrants, and obligatory testing.\n\nThe distribution of scarce resources for testing: We emphasize the use of needs-based criteria, but also acknowledge the importance of choosing a testing strategy that contributes efficiently to stopping the overall spread of the disease. Commercial direct-to-consumer test services: Except in cases of acute scarcity, such services will in practice have to be allowed. We propose that they should be subject to regulation that ensures test quality and adequate information to users. Testing of unauthorized immigrants, their children and other people with unclear legal status: Like everyone else, these individuals may be in need of testing, and it is in society's interest to reach them with testing in order to stop the spread of the disease. A society that offers comprehensive medical services to unauthorized immigrants is in a much better position to reach them in a pandemic than a society that previously excluded them from healthcare. Obligatory testing: While there are often strong reasons for universal testing in residential areas or on workplaces, there are in most cases better ways to achieve testing coverage than to make testing mandatory.\n\nIn summary, we propose (1) decision-making primarily based on needs-based criteria, (2) strict regulation but not prohibition of direct-to-consumer test services, (3) test services offered to unauthorized immigrants, preferably as part of comprehensive medical services, and (4) broad outreach of testing services whenever possible, but in general not obligatory testing.", "doi": "10.1186/s12910-021-00640-4", "pmid": "34158041", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12910-021-00640-4"}, {"db": "pmc", "key": "PMC8218570"}], "notes": [], "created": "2021-06-28T18:18:53.622Z", "modified": "2021-06-28T18:18:53.673Z"}, {"entity": "publication", "iuid": "906776760124487f9e2989bb99a3f45d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/906776760124487f9e2989bb99a3f45d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/906776760124487f9e2989bb99a3f45d"}}, "title": "Recent MMR vaccination in health care workers and Covid-19: A test negative case-control study.", "authors": [{"family": "Lundberg", "given": "Lisa", "initials": "L"}, {"family": "Bygdell", "given": "Maria", "initials": "M"}, {"family": "Stukat von Feilitzen", "given": "Gustaf", "initials": "G"}, {"family": "Woxenius", "given": "Susanne", "initials": "S"}, {"family": "Ohlsson", "given": "Claes", "initials": "C"}, {"family": "Kindblom", "given": "Jenny M", "initials": "JM"}, {"family": "Leach", "given": "Susannah", "initials": "S"}], "type": "journal article", "published": "2021-06-22", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null}, "abstract": "It has been hypothesised that the measles-mumps-rubella (MMR) vaccine may afford cross-protection against SARS-CoV-2 which may contribute to the wide variability in disease severity of Covid-19.\n\nWe employed a test negative case-control study, utilising a recent measles outbreak during which many healthcare workers received the MMR vaccine, to investigate the potential protective effect of MMR against SARS-CoV-2 in 5905 subjects (n = 805 males, n = 5100 females).\n\nThe odds ratio for testing positive for SARS-CoV-2, in recently MMR-vaccinated compared to not recently MMR-vaccinated individuals was 0.91 (95% CI 0.76, 1.09). An interaction analysis showed a significant interaction for sex. After sex-stratification, the odds ratio for testing positive for males was 0.43 (95% CI 0.24, 0.79, P = 0.006), and 1.01 (95% CI 0.83, 1.22, P = 0.92) for females.\n\nOur results indicate that there may be a protective effect of the MMR vaccine against SARS-CoV-2 in males but not females.", "doi": "10.1016/j.vaccine.2021.06.045", "pmid": "34187707", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(21)00795-7"}, {"db": "pmc", "key": "PMC8216866"}], "notes": [], "created": "2021-07-05T14:22:17.192Z", "modified": "2021-07-05T14:22:40.368Z"}, {"entity": "publication", "iuid": "abf861e7ee84401fa61a6a136b81d21b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abf861e7ee84401fa61a6a136b81d21b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abf861e7ee84401fa61a6a136b81d21b"}}, "title": "Obesity Strongly Predicts COVID-19-Related Major Clinical Adverse Events in Coptic Clergy.", "authors": [{"family": "Henein", "given": "Michael Y", "initials": "MY", "orcid": "0000-0002-6089-5614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe79bb10eb4348948599443b7b396faf.json"}}, {"family": "Byty\u00e7i", "given": "Ibadete", "initials": "I", "orcid": "0000-0002-8996-4257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba2f218876104573a8e529b1c2b6f671.json"}}, {"family": "Nicoll", "given": "Rachel", "initials": "R"}, {"family": "Shenouda", "given": "Rafik", "initials": "R"}, {"family": "Ayad", "given": "Sherif", "initials": "S", "orcid": "0000-0002-1737-0142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6bd437e0e8d54056959e5077471e1542.json"}}, {"family": "Vancheri", "given": "Federico", "initials": "F"}, {"family": "Cameli", "given": "Matteo", "initials": "M", "orcid": "0000-0003-3872-8964", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e64899d051a84cd8a0cac5f503e03251.json"}}], "type": "journal article", "published": "2021-06-22", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "10", "issue": "13", "issn-l": "2077-0383"}, "abstract": "The Coptic clergy, due to their specific work involving interaction with many people, could be subjected to increased risk of infection from COVID-19. The aim of this study, a sub-study of the COVID-19-CVD international study of the impact of the pandemic on the cardiovascular system, was to assess the prevalence of COVID-19 among Coptic priests and to identify predictors of clinical adverse events.\n\nParticipants were geographically divided into three groups: Group-I: Europe and USA, Group II: Northern Egypt, and Group III: Southern Egypt. Participants' demographic indices, cardiovascular risk factors, possible source of infection, number of liturgies, infection management, and major adverse events (MAEs), comprising death, or mechanical ventilation, were assessed.\n\nOut of the 1570 clergy serving in 25 dioceses, 255 (16.2%) were infected. Their mean age was 49.5 \u00b1 12 years and mean weekly number of liturgies was 3.44 \u00b1 1.0. The overall prevalence rate was 16.2% and did not differ between Egypt as a whole and overseas (p = 0.23). Disease prevalence was higher in Northern Egypt clergy compared with Europe and USA combined (18.4% vs. 12.1%, p = 0.03) and tended to be higher than in Southern Egypt (18.4% vs. 13.6%, p = 0.09). Ten priests (3.92%) died of COVID-19-related complications, and 26 (10.2) suffered a MAE. The clergy from Southern Egypt were more obese, but the remaining risk factors were less prevalent compared with those in Europe and USA (p = 0.01). In multivariate analysis, obesity (OR = 4.180; 2.479 to 12.15; p = 0.01), age (OR = 1.055; 0.024 to 1.141; p = 0.02), and systemic hypertension (OR = 1.931; 1.169 to 2.004; p = 0.007) predicted MAEs. Obesity was the most powerful independent predictor of MAE in Southern Egypt and systemic hypertension in Northern Egypt (p < 0.05 for both).\n\nObesity is very prevalent among Coptic clergy and seems to be the most powerful independent predictor of major COVID-19-related adverse events. Coptic clergy should be encouraged to follow the WHO recommendations for cardiovascular disease and COVID-19 prevention.", "doi": "10.3390/jcm10132752", "pmid": "34206658", "labels": {"Type: Review": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "jcm10132752"}], "notes": [], "created": "2021-07-05T14:36:08.009Z", "modified": "2021-07-05T14:36:08.112Z"}, {"entity": "publication", "iuid": "711c5ab1909448a5aef6875fa091021f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/711c5ab1909448a5aef6875fa091021f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/711c5ab1909448a5aef6875fa091021f"}}, "title": "Fear of COVID-19 and Perceived COVID-19 Infectability Supplement Theory of Planned Behavior to Explain Iranians' Intention to Get COVID-19 Vaccinated.", "authors": [{"family": "Yahaghi", "given": "Rafat", "initials": "R"}, {"family": "Ahmadizade", "given": "Safie", "initials": "S"}, {"family": "Fotuhi", "given": "Razie", "initials": "R"}, {"family": "Taherkhani", "given": "Elham", "initials": "E"}, {"family": "Ranjbaran", "given": "Mehdi", "initials": "M", "orcid": "0000-0002-0313-3373", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c6b9820cfd99430a938c9653d46f6322.json"}}, {"family": "Buchali", "given": "Zeinab", "initials": "Z"}, {"family": "Jafari", "given": "Robabe", "initials": "R"}, {"family": "Zamani", "given": "Narges", "initials": "N"}, {"family": "Shahbazkhania", "given": "Azam", "initials": "A"}, {"family": "Simiari", "given": "Hengame", "initials": "H"}, {"family": "Rahmani", "given": "Jalal", "initials": "J"}, {"family": "Yazdi", "given": "Nahid", "initials": "N"}, {"family": "Alijani", "given": "Hashem", "initials": "H"}, {"family": "Poorzolfaghar", "given": "Leila", "initials": "L"}, {"family": "Rajabi", "given": "Fatemeh", "initials": "F"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY", "orcid": "0000-0002-2129-4242", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbadbfea7b6c49aa994a34edda29e192.json"}}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}], "type": "journal article", "published": "2021-06-22", "journal": {"title": "Vaccines", "issn": "2076-393X", "issn-l": null, "volume": "9", "issue": "7", "pages": "684"}, "abstract": "One of the most efficient methods to control the high infection rate of the coronavirus disease 2019 (COVID-19) is to have a high coverage of COVID-19 vaccination worldwide. Therefore, it is important to understand individuals' intention to get COVID-19 vaccinated. The present study applied the Theory of Planned Behavior (TPB) to explain the intention to get COVID-19 vaccinated among a representative sample in Qazvin, Iran. The TPB uses psychological constructs of attitude, subjective norm, and perceived behavioral control to explain an individual's intention to perform a behavior. Fear and perceived infectability were additionally incorporated into the TPB to explain the intention to get COVID-19 vaccinated. Utilizing multistage stratified cluster sampling, 10,843 participants (4092 males; 37.7%) with a mean age of 35.54 years (SD = 12.00) completed a survey. The survey assessed TPB constructs (including attitude, subjective norm, perceived behavioral control, and intention related to COVID-19 vaccination) together with fear of COVID-19 and perceived COVID-19 infectability. Structural equation modeling (SEM) was performed to examine whether fear of COVID-19, perceived infectability, and the TPB constructs explained individuals' intention to get COVID-19 vaccinated. The SEM demonstrated satisfactory fit (comparative fit index = 0.970; Tucker-Lewis index = 0.962; root mean square error of approximation = 0.040; standardized root mean square residual = 0.050). Moreover, perceived behavioral control, subjective norm, attitude, and perceived COVID-19 infectability significantly explained individuals' intention to get COVID-19 vaccinated. Perceived COVID-19 infectability and TPB constructs were all significant mediators in the relationship between fear of COVID-19 and intention to get COVID-19 vaccinated. Incorporating fear of COVID-19 and perceived COVID-19 infectability effectively into the TPB explained Iranians' intention to get COVID-19 vaccinated. Therefore, Iranians who have a strong belief in Muslim religion may improve their intention to get COVID-19 vaccinated via these constructs.", "doi": "10.3390/vaccines9070684", "pmid": "34206226", "labels": {"Category: Public Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8310138"}, {"db": "pii", "key": "vaccines9070684"}], "notes": [], "created": "2021-07-05T14:35:28.108Z", "modified": "2023-06-19T15:21:14.367Z"}, {"entity": "publication", "iuid": "a072af27feb64a60bed14b2e4089a3d4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a072af27feb64a60bed14b2e4089a3d4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a072af27feb64a60bed14b2e4089a3d4"}}, "title": "Adapting the Motors of Influenza Vaccination Acceptance Scale into the Motors of COVID-19 Vaccination Acceptance Scale: Psychometric evaluation among mainland Chinese university students.", "authors": [{"family": "Chen", "given": "I-Hua", "initials": "IH"}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Ko", "given": "Nai-Ying", "initials": "NY"}, {"family": "Yen", "given": "Cheng-Fang", "initials": "CF"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-06-22", "journal": {"title": "Vaccine", "issn": "1873-2518", "issn-l": null}, "abstract": "COVID-19 continues to ravage the world with economies and life significantly and negatively affected. Fortunately, there has been significant progress in the production of vaccines to stem the infection. However, with controversies and myths surrounding vaccinations, it is timely to examine individuals' willingness to vaccinate. The present study adapted the Motors of Influenza Vaccination Acceptance Scale (MoVac-Flu Scale) into the Motors of COVID-19 Vaccination Acceptance Scale (MoVac-COVID19S) for validation and assessed the acceptance of COVID-19 vaccination utilizing the cognitive model of empowerment (CME).\n\nA total of 3145 university students (mean age = 20.80 years; SD = 2.09) were recruited for the present study between January 5 and 16, 2021. Two MoVac-COVID19S scales (9-item and 12-item) were adapted from the MoVac-Flu Scale, an instrument developed using CME. Psychometric tests were conducted to ascertain reliability and validity properties.\n\nThe findings indicated that the MoVac-COVID19S had high internal consistency in both the 9-item version (\u03c9 = 0.921) and 12-item version (\u03c9 = 0.898). The factor structure of the MoVac-COVID19S (9-item and 12-item versions) corresponded well with CME theory. All the fit indices were satisfactory (comparative fit index = 0.984, Tucker-Lewis index = 0.971, root mean square error of approximation = 0.088, standardized root mean square residual = 0.058) but the 9-item MoVac-COVID had better fit indices than the 12-item MoVac-COVID due to the negative wording effects existing in the 12-item MoVac-COVID19S. The scale had satisfactory known-group validity in both 9-item and 12-item versions.\n\nThe MoVac-COVID19S has promising psychometric properties based on internal consistency, factor structure, and known-group validity.", "doi": "10.1016/j.vaccine.2021.06.044", "pmid": "34217571", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(21)00794-5"}], "notes": [], "created": "2021-07-05T15:04:14.711Z", "modified": "2021-07-05T15:04:14.722Z"}, {"entity": "publication", "iuid": "d2e4dfecaa2b457ca2deddac6fa256e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d2e4dfecaa2b457ca2deddac6fa256e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d2e4dfecaa2b457ca2deddac6fa256e1"}}, "title": "Problems associated with mass border testing of COVID-19.", "authors": [{"family": "Grun\u00e9r", "given": "Mathias", "initials": "M"}, {"family": "Nordberg", "given": "Marika", "initials": "M"}, {"family": "L\u00f6nnroth", "given": "Knut", "initials": "K"}], "type": "journal article", "published": "2021-06-19", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": null, "issue": null, "pages": "14034948211023659"}, "abstract": "We evaluated the yield of exit screening for SARS-Cov-2 performed in order for travellers to meet entry requirements to Sweden. Among 472 people screened, no infectious case of COVID-19 was detected, while two previously known cases were redetected after having already completed isolation. Our data suggest that depending on the epidemiological situation in the area of departure, border screening can lead to very low positive predictive values and very high costs per relevant case detected.", "doi": "10.1177/14034948211023659", "pmid": "34148440", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:27:36.293Z", "modified": "2021-07-14T11:05:48.211Z"}, {"entity": "publication", "iuid": "c47615463a5942ea9282f007e05a3647", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c47615463a5942ea9282f007e05a3647.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c47615463a5942ea9282f007e05a3647"}}, "title": "Organizational Support Experiences of Care Home and Home Care Staff in Sweden, Italy, Germany and the United Kingdom during the COVID-19 Pandemic", "authors": [{"family": "Lethin", "given": "Connie", "initials": "C", "orcid": "0000-0002-2523-8440", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e4dbde29c2949e09fdeff309bf402e2.json"}}, {"family": "Kenkmann", "given": "Andrea", "initials": "A", "orcid": "0000-0002-9252-2345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5447bed983d94bd3b6ba83eee314ec89.json"}}, {"family": "Chiatti", "given": "Carlos", "initials": "C", "orcid": "0000-0003-4810-9630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f7b5ce4271844684965d8c4abe0cd66c.json"}}, {"family": "Christensen", "given": "Jonas", "initials": "J", "orcid": "0000-0003-0428-2001", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/66ccc78bb50f4b37a7365eb8154419a9.json"}}, {"family": "Backhouse", "given": "Tamara", "initials": "T", "orcid": "0000-0001-8194-4174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64556c498dd94570ae0a35f2ae892328.json"}}, {"family": "Killett", "given": "Anne", "initials": "A"}, {"family": "Fisher", "given": "Oliver", "initials": "O", "orcid": "0000-0003-2787-2899", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6f8c5634b75c486b9c00ab54738c43cd.json"}}, {"family": "Malmgren F\u00e4nge", "given": "Agneta", "initials": "A", "orcid": "0000-0002-3165-1856", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b47b1c9adc81409ba189a6cec7643f4a.json"}}], "type": "journal-article", "published": "2021-06-19", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "issn-l": null, "volume": "9", "issue": "6", "pages": "767"}, "abstract": "The COVID-19 pandemic has affected care workers all over the globe, as older and more vulnerable people face a high risk of developing severe symptoms and dying from the virus infection. The aim of this study was to compare staff experiences of stress and anxiety as well as internal and external organizational support in Sweden, Italy, Germany, and the United Kingdom (UK) in order to determine how care staff were affected by the pandemic. A 29-item online questionnaire was used to collect data from care staff respondents: management (n = 136), nurses (n = 132), nursing assistants (n = 195), and other healthcare staff working in these organizations (n = 132). Stress and anxiety levels were highest in the UK and Germany, with Swedish staff showing the least stress. Internal and external support only partially explain the outcomes. Striking discrepancies between different staff groups' assessment of organizational support as well as a lack of staff voice in the UK and Germany could be key factors in understanding staff's stress levels during the pandemic. Structural, political, cultural, and economic factors play a significant role, not only factors within the care organization or in the immediate context.", "doi": "10.3390/healthcare9060767", "pmid": "34205430", "labels": {"Category: Public Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8233956"}, {"db": "pii", "key": "healthcare9060767"}], "notes": [], "created": "2021-07-05T14:34:33.693Z", "modified": "2023-06-19T07:30:08.818Z"}, {"entity": "publication", "iuid": "73dc7c5305684104bbfa82bbc77ab961", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/73dc7c5305684104bbfa82bbc77ab961.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/73dc7c5305684104bbfa82bbc77ab961"}}, "title": "Stable IgG-antibody levels in patients with mild SARS-CoV-2 infection", "authors": [{"family": "\u00c5kerlund", "given": "Thomas", "initials": "T"}, {"family": "Zakikhany", "given": "Katherina", "initials": "K"}, {"family": "L\u00f6fstr\u00f6m", "given": "Charlotta", "initials": "C"}, {"family": "Lindmark", "given": "Evelina", "initials": "E"}, {"family": "K\u00e4llberg", "given": "Henrik", "initials": "H"}, {"family": "Elofsson", "given": "Ulla", "initials": "U"}, {"family": "Cederbrant", "given": "Karin", "initials": "K"}, {"family": "Nygren", "given": "Erik", "initials": "E"}, {"family": "Kallin", "given": "Anders", "initials": "A"}, {"family": "Lagerqvist", "given": "Nina", "initials": "N"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Wollberg", "given": "Anna Ridderstad", "initials": "AR"}, {"family": "Bj\u00f6rndal", "given": "\u00c5sa Szekely", "initials": "\u00c5S"}], "type": "posted-content", "published": "2021-06-18", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.06.16.21258960", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-11-18T16:39:34.128Z", "modified": "2021-11-18T16:39:50.737Z"}, {"entity": "publication", "iuid": "22939049e0964fe4910f0c36ed045304", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/22939049e0964fe4910f0c36ed045304.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/22939049e0964fe4910f0c36ed045304"}}, "title": "Everyday life in a Swedish nursing home during the COVID-19 pandemic: a qualitative interview study with persons 85 to 100 years.", "authors": [{"family": "Lood", "given": "Qarin", "initials": "Q", "orcid": "0000-0002-6187-0929", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/205301c28ae14612b3df0603d39adabb.json"}}, {"family": "Haak", "given": "Maria", "initials": "M"}, {"family": "Dahlin-Ivanoff", "given": "Synneve", "initials": "S"}], "type": "journal article", "published": "2021-06-18", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "6", "pages": "e048503"}, "abstract": "To understand and report on the impact of the COVID-19 pandemic on the everyday lives of frail older persons living in nursing homes by exploring their experiences of how the pandemic-related restrictions had influenced them and in what way.\n\nEmpirical qualitative interview study.\n\nA publicly run nursing home in an urban area in Sweden in June 2020. The nursing home had visitor restrictions, cancelled activities and physical distancing requirements since March 2020.\n\nA total of 10 persons, 85-100 years, living in a Swedish nursing home during the COVID-19 pandemic, were recruited through nursing home management and interviewed in June 2020 using medically approved visors and physical distancing.\n\nInterviews were analysed using thematic analysis, which involves familiarisation, coding and definition of themes. Transcripts were coded into data-driven categories before being organised into categories that described and explained the data.\n\nThe analysis resulted in the main theme 'It is like living in a bubble', that describes everyday life in the nursing home during the pandemic as a world of its own in which the older persons felt both protected and isolated. This is described in four subthemes: living 1 day at a time, without fear of the virus; feeling taken care of; having limited freedom and missing out on the little extras.\n\nContributing to the growing area of COVID-19-related research, our findings provide novel insights into how pandemic-related restrictions in nursing homes represent a risk of isolating older people from the outside world and diminishing their freedom. Put in relation to the previous research, these findings could be applied beyond the pandemic, to develop research and practice that puts focus on how to support older people to decide for themselves how to spend the rest of their lives.", "doi": "10.1136/bmjopen-2020-048503", "pmid": "34145018", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8214988"}, {"db": "pii", "key": "bmjopen-2020-048503"}], "notes": [], "created": "2021-06-28T18:28:49.224Z", "modified": "2023-06-19T15:05:00.460Z"}, {"entity": "publication", "iuid": "95767140345346129cb142e2870772c7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95767140345346129cb142e2870772c7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95767140345346129cb142e2870772c7"}}, "title": "The Impact of the Renin-Angiotensin-Aldosterone System on Inflammation, Coagulation, and Atherothrombotic Complications, and to Aggravated COVID-19.", "authors": [{"family": "Ekholm", "given": "M", "initials": "M"}, {"family": "Kahan", "given": "T", "initials": "T"}], "type": "journal article", "published": "2021-06-17", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "12", "pages": "640185", "issn-l": "1663-9812"}, "abstract": "Atherosclerosis is considered a disease caused by a chronic inflammation, associated with endothelial dysfunction, and several mediators of inflammation are up-regulated in subjects with atherosclerotic disease. Healthy, intact endothelium exhibits an antithrombotic, protective surface between the vascular lumen and vascular smooth muscle cells in the vessel wall. Oxidative stress is an imbalance between anti- and prooxidants, with a subsequent increase of reactive oxygen species, leading to tissue damage. The renin-angiotensin-aldosterone system is of vital importance in the pathobiology of vascular disease. Convincing data indicate that angiotensin II accelerates hypertension and augments the production of reactive oxygen species. This leads to the generation of a proinflammatory phenotype in human endothelial and vascular smooth muscle cells by the up-regulation of adhesion molecules, chemokines and cytokines. In addition, angiotensin II also seems to increase thrombin generation, possibly via a direct impact on tissue factor. However, the mechanism of cross-talk between inflammation and haemostasis can also contribute to prothrombotic states in inflammatory environments. Thus, blocking of the renin-angiotensin-aldosterone system might be an approach to reduce both inflammatory and thrombotic complications in high-risk patients. During COVID-19, the renin-angiotensin-aldosterone system may be activated. The levels of angiotensin II could contribute to the ongoing inflammation, which might result in a cytokine storm, a complication that significantly impairs prognosis. At the outbreak of COVID-19 concerns were raised about the use of angiotensin converting enzyme inhibitors and angiotensin receptor blocker drugs in patients with COVID-19 and hypertension or other cardiovascular comorbidities. However, the present evidence is in favor of continuing to use of these drugs. Based on experimental evidence, blocking the renin-angiotensin-aldosterone system might even exert a potentially protective influence in the setting of COVID-19.", "doi": "10.3389/fphar.2021.640185", "pmid": "34220496", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "640185"}, {"db": "pmc", "key": "PMC8245685"}], "notes": [], "created": "2021-07-06T05:41:56.778Z", "modified": "2021-08-06T08:53:09.932Z"}, {"entity": "publication", "iuid": "4c9b64be8bb24857b13e370d1b34c219", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4c9b64be8bb24857b13e370d1b34c219.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4c9b64be8bb24857b13e370d1b34c219"}}, "title": "Sphingolipids as Modulators of SARS-CoV-2 Infection.", "authors": [{"family": "T\u00f6rnquist", "given": "Kid", "initials": "K"}, {"family": "Asghar", "given": "Muhammad Yasir", "initials": "MY"}, {"family": "Srinivasan", "given": "Vignesh", "initials": "V"}, {"family": "Korhonen", "given": "Laura", "initials": "L"}, {"family": "Lindholm", "given": "Dan", "initials": "D"}], "type": "journal article", "published": "2021-06-17", "journal": {"title": "Front Cell Dev Biol", "issn": "2296-634X", "volume": "9", "pages": "689854", "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic with severe consequences for afflicted individuals and the society as a whole. The biology and infectivity of the virus has been intensively studied in order to gain a better understanding of the molecular basis of virus-host cell interactions during infection. It is known that SARS-CoV-2 binds to angiotensin-converting enzyme 2 (ACE2) via its spike protein. Priming of the virus by specific proteases leads to viral entry via endocytosis and to the subsequent steps in the life cycle of SARS-CoV-2. Sphingosine and ceramide belong to the sphingolipid family and are abundantly present in cell membranes. These lipids were recently shown to interfere with the uptake of virus particles of SARS-CoV-2 into epithelial cell lines and primary human nasal cells in culture. The mechanisms of action were partly different, as sphingosine blocked, whilst ceramide facilitated viral entry. Acid sphingomyelinase (ASM) is vital for the generation of ceramide and functional inhibition of ASM by drugs like amitriptyline reduced SARS-CoV-2 entry into the epithelial cells. Recent data indicates that serum level of sphingosine-1-phosphate (S1P) is a prognostic factor for COVID-2 severity. Further, stimulation of sphingosine-1-phosphate receptor 1 (S1PR1) might also constrain the hyper-inflammatory conditions linked to SARS-CoV-2. Here, we review recent exciting findings regarding sphingolipids in the uptake of SARS-CoV-2 and in the course of COVID-19 disease. More studies are required on the mechanisms of action and the potential use of antidepressant drugs and sphingolipid modifiers in SARS-CoV-2 infections and in the treatment of the more serious and fatal consequences of the disease.", "doi": "10.3389/fcell.2021.689854", "pmid": "34222257", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8245774"}], "notes": [], "created": "2021-07-06T05:41:28.669Z", "modified": "2021-08-06T08:48:14.607Z"}, {"entity": "publication", "iuid": "8b2f9bd35e10430bb600b4d2574b92bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b2f9bd35e10430bb600b4d2574b92bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b2f9bd35e10430bb600b4d2574b92bd"}}, "title": "Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2.", "authors": [{"family": "Roxhed", "given": "Niclas", "initials": "N", "orcid": "0000-0002-7147-6730", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cda793d04e544bbcb7adbd7a8f3de217.json"}}, {"family": "Bendes", "given": "Annika", "initials": "A", "orcid": "0000-0001-9329-2353", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87d0283c178b4aaeb0c3f1ad9187de7b.json"}}, {"family": "Dale", "given": "Matilda", "initials": "M", "orcid": "0000-0002-5788-7744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fbf8052f5b8449fabd27adb8316b973.json"}}, {"family": "Mattsson", "given": "Cecilia", "initials": "C"}, {"family": "Hanke", "given": "Leo", "initials": "L", "orcid": "0000-0001-5514-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a35f10de4f2e4aee98278f6ab845613d.json"}}, {"family": "Dodig-Crnkovi\u0107", "given": "Tea", "initials": "T", "orcid": "0000-0002-2875-896X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/63ccd5c5d27e4c11bd60a689e9d4a571.json"}}, {"family": "Christian", "given": "Murray", "initials": "M"}, {"family": "Meineke", "given": "Birthe", "initials": "B"}, {"family": "Els\u00e4sser", "given": "Simon", "initials": "S", "orcid": "0000-0001-8724-4849", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5521b3e3c4fa4e1c8eb4e19a079971a8.json"}}, {"family": "Andr\u00e9ll", "given": "Juni", "initials": "J"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1345-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a53a433db6f04a458e3d420f0c9995c5.json"}}, {"family": "Eklund", "given": "Carina", "initials": "C"}, {"family": "Dillner", "given": "Joakim", "initials": "J", "orcid": "0000-0001-8588-6506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bbb8b0ca5dc648e0b80c1de224b26c69.json"}}, {"family": "Beck", "given": "Olof", "initials": "O"}, {"family": "Thomas", "given": "Cecilia E", "initials": "CE", "orcid": "0000-0001-6201-6380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d34036550b84e67ae3185c65a857c95.json"}}, {"family": "McInerney", "given": "Gerald", "initials": "G", "orcid": "0000-0003-2257-7241", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7770437d845444a8a07865bf5b62fab0.json"}}, {"family": "Hong", "given": "Mun-Gwan", "initials": "MG", "orcid": "0000-0001-8603-8293", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3fa0aa1a11e4d2ca5356a8a708536b2.json"}}, {"family": "Murrell", "given": "Ben", "initials": "B", "orcid": "0000-0002-0393-4445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60dac9ecf84d4eb3b90fb4ee1298bc52.json"}}, {"family": "Fredolini", "given": "Claudia", "initials": "C", "orcid": "0000-0002-7674-2014", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/680bda0d693149f28ac18dff239101a8.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67a59fa5de37434c8b7151039c192a37.json"}}], "type": "journal article", "published": "2021-06-17", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "3695"}, "abstract": "Serological testing is essential to curb the consequences of the COVID-19 pandemic. However, most assays are still limited to single analytes and samples collected within healthcare. Thus, we establish a multianalyte and multiplexed approach to reliably profile IgG and IgM levels against several versions of SARS-CoV-2 proteins (S, RBD, N) in home-sampled dried blood spots (DBS). We analyse DBS collected during spring of 2020 from 878 random and undiagnosed individuals from the population in Stockholm, Sweden, and use classification approaches to estimate an accumulated seroprevalence of 12.5% (95% CI: 10.3%-14.7%). This includes 5.4% of the samples being IgG+IgM+ against several SARS-CoV-2 proteins, as well as 2.1% being IgG-IgM+ and 5.0% being IgG+IgM- for the virus' S protein. Subjects classified as IgG+ for several SARS-CoV-2 proteins report influenza-like symptoms more frequently than those being IgG+ for only the S protein (OR = 6.1; p < 0.001). Among all seropositive cases, 30% are asymptomatic. Our strategy enables an accurate individual-level and multiplexed assessment of antibodies in home-sampled blood, assisting our understanding about the undiagnosed seroprevalence and diversity of the immune response against the coronavirus.", "doi": "10.1038/s41467-021-23893-4", "pmid": "34140485", "labels": {"Funder: H2020": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Serology": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Host cell systems biology and targets": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8211676"}, {"db": "pii", "key": "10.1038/s41467-021-23893-4"}], "notes": [], "created": "2021-06-18T08:23:45.977Z", "modified": "2023-06-19T14:19:51.535Z"}, {"entity": "publication", "iuid": "0c407443885c4bbe84294a5ea15a53c7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c407443885c4bbe84294a5ea15a53c7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c407443885c4bbe84294a5ea15a53c7"}}, "title": "Extracorporeal membrane oxygenation for COVID-19 during first and second waves.", "authors": [{"family": "Broman", "given": "Lars Mikael", "initials": "LM"}, {"family": "Eksborg", "given": "Staffan", "initials": "S"}, {"family": "Coco", "given": "Valeria Lo", "initials": "VL"}, {"family": "De Piero", "given": "Maria Elena", "initials": "ME"}, {"family": "Belohlavek", "given": "Jan", "initials": "J"}, {"family": "Lorusso", "given": "Roberto", "initials": "R"}, {"family": "EuroECMO COVID-19 Working Group", "given": "", "initials": ""}, {"family": "Euro-ELSO Steering Committee", "given": "", "initials": ""}], "type": "letter", "published": "2021-06-16", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "issn-l": "2213-2600"}, "abstract": null, "doi": "10.1016/S2213-2600(21)00262-9", "pmid": "34146489", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(21)00262-9"}], "notes": [], "created": "2021-06-28T18:28:29.820Z", "modified": "2021-06-28T18:28:29.830Z"}, {"entity": "publication", "iuid": "784a4f6aae174440bf672e8ddc642b24", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/784a4f6aae174440bf672e8ddc642b24.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/784a4f6aae174440bf672e8ddc642b24"}}, "title": "Correction to: Risk of stress/depression and functional impairment in Denmark immediately following a COVID-19 shutdown.", "authors": [{"family": "Andersen", "given": "Lars H", "initials": "LH"}, {"family": "Fallesen", "given": "Peter", "initials": "P"}, {"family": "Bruckner", "given": "Tim A", "initials": "TA"}], "type": "published erratum", "published": "2021-06-16", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "volume": "21", "issue": "1", "pages": "1155", "issn-l": null}, "abstract": null, "doi": "10.1186/s12889-021-11204-x", "pmid": "34134702", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11204-x"}, {"db": "pmc", "key": "PMC8206909"}], "notes": [], "created": "2021-06-28T18:42:42.794Z", "modified": "2021-06-28T18:42:42.806Z"}, {"entity": "publication", "iuid": "60d0dac7396d423d8a6e2ada45422709", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60d0dac7396d423d8a6e2ada45422709.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60d0dac7396d423d8a6e2ada45422709"}}, "title": "COVID-19 and Delayed Cerebral Ischemia-More in Common Than First Meets the Eye.", "authors": [{"family": "Bhogal", "given": "Pervinder", "initials": "P"}, {"family": "Makalanda", "given": "Levansri", "initials": "L", "orcid": "0000-0001-6637-9293", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e57d3cb6d01c4a3d96234e31e2f471a1.json"}}, {"family": "Hassan", "given": "Ameer E", "initials": "AE", "orcid": "0000-0002-7148-7616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f5948193707428eac79c94a082dc3a9.json"}}, {"family": "Fiorella", "given": "Dave", "initials": "D"}, {"family": "Andersson", "given": "Tommy", "initials": "T", "orcid": "0000-0001-8202-7829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec80cd01fb984f2c927728d554f3d220.json"}}, {"family": "Ahmad", "given": "Muhammad", "initials": "M"}, {"family": "B\u00e4zner", "given": "Hansj\u00f6rg", "initials": "H"}, {"family": "Jaffer", "given": "Ounali", "initials": "O"}, {"family": "Henkes", "given": "Hans", "initials": "H", "orcid": "0000-0002-6534-036X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8a14520c05674ca4aba1925525002829.json"}}], "type": "journal article", "published": "2021-06-16", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "10", "issue": "12", "issn-l": "2077-0383"}, "abstract": "Since the arrival of the global COVID-19 pandemic scientists around the world have been working to understand the pathological mechanisms resulting from infection. There has gradually been an understanding that COVID-19 triggers a widespread endotheliopathy and that this can result in a widespread thrombosis and in particular a microthrombosis. The mechanisms involved in the microthrombosis are not confined to infection and there is evidence that patients with aneurysmal sub-arachnoid haemorrhage (SAH) also suffer from an endotheliopathy and microthrombosis. In this article we attempt to shed light on similarities in the underlying processes involved in both diseases and suggest potential treatment options.", "doi": "10.3390/jcm10122646", "pmid": "34208470", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jcm10122646"}], "notes": [], "created": "2021-07-05T14:44:28.293Z", "modified": "2021-07-05T14:56:22.840Z"}, {"entity": "publication", "iuid": "875647dd80d9464088d6306cf0bccf64", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/875647dd80d9464088d6306cf0bccf64.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/875647dd80d9464088d6306cf0bccf64"}}, "title": "A novel automated SARS-CoV-2 saliva PCR test protects a global asymptomatic workforce.", "authors": [{"family": "Carter", "given": "Nikki", "initials": "N"}, {"family": "Clausen", "given": "Maryam", "initials": "M"}, {"family": "Halpin", "given": "Rebecca A", "initials": "RA"}, {"family": "Blackmore", "given": "Colin", "initials": "C"}, {"family": "Cai", "given": "Kang", "initials": "K"}, {"family": "Delpuech", "given": "Oona", "initials": "O"}, {"family": "Kohlmann", "given": "Alexander", "initials": "A"}, {"family": "Magnusson", "given": "Otto", "initials": "O"}, {"family": "March", "given": "Ruth", "initials": "R"}, {"family": "O'Neill", "given": "Daniel", "initials": "D"}, {"family": "Prakash", "given": "Kasthuri", "initials": "K"}, {"family": "Sherwood", "given": "James", "initials": "J"}, {"family": "Sundin", "given": "Tabetha", "initials": "T"}, {"family": "Swift", "given": "Jason", "initials": "J"}, {"family": "Tarakameh", "given": "Azar", "initials": "A"}, {"family": "Wijdicks", "given": "Marilou", "initials": "M"}, {"family": "Wise", "given": "Daniel", "initials": "D"}, {"family": "Fidock", "given": "Mark", "initials": "M"}], "type": "journal article", "published": "2021-06-16", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "12676"}, "abstract": "Regular PCR testing of nasopharyngeal swabs from symptomatic individuals for SARS-CoV-2 virus has become the established method by which health services are managing the COVID-19 pandemic. Businesses such as AstraZeneca have also prioritised voluntary asymptomatic testing to keep workplaces safe and maintain supply of essential medicines to patients. We describe the development of an internal automated SARS-CoV-2 testing programme including the transformative introduction of saliva as an alternative sample type.", "doi": "10.1038/s41598-021-92070-w", "pmid": "34135391", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-92070-w"}, {"db": "pmc", "key": "PMC8209156"}], "notes": [], "created": "2021-06-28T18:42:21.621Z", "modified": "2021-06-30T05:10:06.409Z"}, {"entity": "publication", "iuid": "3964c56151144b969fd3dbc05ed3069c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3964c56151144b969fd3dbc05ed3069c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3964c56151144b969fd3dbc05ed3069c"}}, "title": "SARS-CoV-2 Spike protein binding of glycated serum albumin - its potential role in the pathogenesis of the COVID-19 clinical syndromes and bias towards individuals with pre-diabetes/type 2 diabetes &amp; metabolic diseases", "authors": [{"family": "IIes", "given": "Jason K", "initials": "JK"}, {"family": "Zmuidinaite", "given": "Raminta", "initials": "R", "orcid": "0000-0001-7728-6623", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/421ae7d6575445888ac6bb7f537b4b16.json"}}, {"family": "Sadee", "given": "Christoph", "initials": "C"}, {"family": "Gardiner", "given": "Anna", "initials": "A"}, {"family": "Lacey", "given": "Jonathan", "initials": "J"}, {"family": "Harding", "given": "Stephen", "initials": "S"}, {"family": "Ule", "given": "Jernej", "initials": "J", "orcid": "0000-0002-2452-4277", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df39ffa7b830405ba54b42987ad9c0cc.json"}}, {"family": "Roblett", "given": "Debra", "initials": "D"}, {"family": "Iles", "given": "Ray K", "initials": "RK", "orcid": "0000-0003-0573-9739", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b815fcd924e64abcaa064fc3482f114f.json"}}], "type": "posted-content", "published": "2021-06-15", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.06.14.21258871", "pmid": null, "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-06-17T07:50:07.080Z", "modified": "2023-06-19T14:18:51.180Z"}, {"entity": "publication", "iuid": "3cedafdf25154a119a7554bb9b330128", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3cedafdf25154a119a7554bb9b330128.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3cedafdf25154a119a7554bb9b330128"}}, "title": "Public acceptance of COVID-19 vaccines: cross-national evidence on levels and individual-level predictors using observational data.", "authors": [{"family": "Lindholt", "given": "Marie Fly", "initials": "MF", "orcid": "0000-0002-8044-2559", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5117f1c9ca11402387d5d5994c8e358a.json"}}, {"family": "J\u00f8rgensen", "given": "Frederik", "initials": "F"}, {"family": "Bor", "given": "Alexander", "initials": "A"}, {"family": "Petersen", "given": "Michael Bang", "initials": "MB"}], "type": "journal article", "published": "2021-06-15", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "6", "pages": "e048172"}, "abstract": "The management of the COVID-19 pandemic hinges on the approval of safe and effective vaccines but, equally importantly, on high vaccine acceptance among people. To facilitate vaccine acceptance via effective health communication, it is key to understand levels of vaccine scepticism and the demographic, psychological and political predictors. To this end, we examine the levels and predictors of acceptance of an approved COVID-19 vaccine.\n\nWe examine the levels and predictors of acceptance of an approved COVID-19 vaccine in large online surveys from eight Western democracies that differ in terms of the severity of the pandemic and their response: Denmark, France, Germany, Hungary, Sweden, Italy, UK and USA (total N=18 231). Survey respondents were quota sampled to match the population margins on age, gender and geographical location for each country. The study was conducted from September 2020 to February 2021, allowing us to assess changes in acceptance and predictors as COVID-19 vaccine programmes were rolled out.\n\nThe outcome of the study is self-reported acceptance of a COVID-19 vaccine approved and recommended by health authorities.\n\nThe data reveal large variations in vaccine acceptance that ranges from 83% in Denmark to 47% in France and Hungary. Lack of vaccine acceptance is associated with lack of trust in authorities and scientists, conspiratorial thinking and a lack of concern about COVID-19.\n\nMost national levels of vaccine acceptance fall below estimates of the required threshold for herd immunity. The results emphasise the long-term importance of building trust in preparations for health emergencies such as the current pandemic. For health communication, the results emphasise the importance of focusing on personal consequences of infections and debunking of myths to guide communication strategies.", "doi": "10.1136/bmjopen-2020-048172", "pmid": "34130963", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8210695"}, {"db": "pii", "key": "bmjopen-2020-048172"}], "notes": [], "created": "2021-06-17T07:38:34.366Z", "modified": "2023-06-19T15:02:47.895Z"}, {"entity": "publication", "iuid": "a41604e113284f04ad764896bff28508", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a41604e113284f04ad764896bff28508.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a41604e113284f04ad764896bff28508"}}, "title": "Point of care detection of COVID-19: Advancement in biosensing and diagnostic methods.", "authors": [{"family": "Suleman", "given": "Shariq", "initials": "S"}, {"family": "Shukla", "given": "Sudheesh K", "initials": "SK"}, {"family": "Malhotra", "given": "Nitesh", "initials": "N"}, {"family": "Bukkitgar", "given": "Shikandar D", "initials": "SD"}, {"family": "Shetti", "given": "Nagaraj P", "initials": "NP"}, {"family": "Pilloton", "given": "Roberto", "initials": "R"}, {"family": "Narang", "given": "Jagriti", "initials": "J"}, {"family": "Nee Tan", "given": "Yen", "initials": "Y"}, {"family": "Aminabhavi", "given": "Tejraj M", "initials": "TM"}], "type": "journal article", "published": "2021-06-15", "journal": {"title": "Chem Eng J", "issn": "1385-8947", "volume": "414", "issue": null, "pages": "128759", "issn-l": null}, "abstract": "The recent outbreak of COVID-19 has created much inconvenience and fear that the virus can seriously affect humans, causing health hazards and death. This pandemic has created much worry and as per the report by World Health Organization (WHO), more than 43 million individuals in 215 countries and territories were affected. People around the world are still struggling to overcome the problems associated with this pandemic. Of all the available methods, reverse-transcriptase polymerase chain reaction (RT-PCR) has been widely practiced for the pandemic detection even though several diagnostic tools are available having varying accuracy and sensitivity. The method offers many advantages making it a life-saving tool, but the method has the limitation of transporting to the nearest pathology lab, thus limiting its application in resource limited settings. This has a risen a crucial need for point-of-care devices for on-site detection. In this venture, biosensors have been used, since they can be applied immediately at the point-of-care. This review will discuss about the available diagnostic methods and biosensors for COVID-19 detection.", "doi": "10.1016/j.cej.2021.128759", "pmid": "33551668", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1385-8947(21)00356-9"}, {"db": "pmc", "key": "PMC7847737"}], "notes": [], "created": "2021-02-10T18:50:48.806Z", "modified": "2021-02-10T18:50:48.828Z"}, {"entity": "publication", "iuid": "b93533b9d7704873b5fafccdffc467be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b93533b9d7704873b5fafccdffc467be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b93533b9d7704873b5fafccdffc467be"}}, "title": "Molecular determinants of disease severity in urinary tract infection.", "authors": [{"family": "Ambite", "given": "Ines", "initials": "I", "orcid": "0000-0003-1470-671X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b32089f6f4634bca8d1aa25dab3f1f1f.json"}}, {"family": "Butler", "given": "Daniel", "initials": "D", "orcid": "0000-0002-6717-545X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/091753e4d1ee46adaae712172033c21e.json"}}, {"family": "Wan", "given": "Murphy Lam Yim", "initials": "MLY"}, {"family": "Rosenblad", "given": "Therese", "initials": "T"}, {"family": "Tran", "given": "Thi Hien", "initials": "TH"}, {"family": "Chao", "given": "Sing Ming", "initials": "SM"}, {"family": "Svanborg", "given": "Catharina", "initials": "C"}], "type": "journal article", "published": "2021-06-15", "journal": {"title": "Nat Rev Urol", "issn": "1759-4820", "issn-l": null}, "abstract": "The most common and lethal bacterial pathogens have co-evolved with the host. Pathogens are the aggressors, and the host immune system is responsible for the defence. However, immune responses can also become destructive, and excessive innate immune activation is a major cause of infection-associated morbidity, exemplified by symptomatic urinary tract infections (UTIs), which are caused, in part, by excessive innate immune activation. Severe kidney infections (acute pyelonephritis) are a major cause of morbidity and mortality, and painful infections of the urinary bladder (acute cystitis) can become debilitating in susceptible patients. Disease severity is controlled at specific innate immune checkpoints, and a detailed understanding of their functions is crucial for strategies to counter microbial aggression with novel treatment and prevention measures. One approach is the use of bacterial molecules that reprogramme the innate immune system, accelerating or inhibiting disease processes. A very different outcome is asymptomatic bacteriuria, defined by low host immune responsiveness to bacteria with attenuated virulence. This observation provides the rationale for immunomodulation as a new therapeutic tool to deliberately modify host susceptibility, control the host response and avoid severe disease. The power of innate immunity as an arbitrator of health and disease is also highly relevant for emerging pathogens, including the current COVID-19 pandemic.", "doi": "10.1038/s41585-021-00477-x", "pmid": "34131331", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41585-021-00477-x"}], "notes": [], "created": "2021-06-17T07:36:27.229Z", "modified": "2021-06-17T07:36:40.244Z"}, {"entity": "publication", "iuid": "725d7eea1cf94a2db46c13223e5682a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/725d7eea1cf94a2db46c13223e5682a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/725d7eea1cf94a2db46c13223e5682a2"}}, "title": "Changes to household income in a Kenyan informal settlement during COVID-19", "authors": [{"family": "Tompsett", "given": "Anna", "initials": "A", "orcid": "0000-0002-5415-6583", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/780bff9b7f844676884c466b184933d1.json"}}, {"family": "Baum", "given": "Aaron", "initials": "A", "orcid": "0000-0003-4999-3480", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9df82e2e71604e7fbd3d3a38280ee2e9.json"}}, {"family": "Bukachi", "given": "Vera", "initials": "V", "orcid": "0000-0003-0448-1983", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6a5c57d3aedd49d69e028bbe47b8b2f7.json"}}, {"family": "Kipkemboi", "given": "Pascal", "initials": "P"}, {"family": "K\u2019oyoo", "given": "Allan Ouko", "initials": "AO"}, {"family": "Varela", "given": "Ana Varela", "initials": "AV", "orcid": "0000-0003-1960-5619", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3604aec1e9445d18b4be865638d6cb1.json"}}, {"family": "Mulligan", "given": "Joseph", "initials": "J", "orcid": "0000-0002-8614-3787", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3c4c96ea8f904b52b0d099c912511547.json"}}], "type": "posted-content", "published": "2021-06-15", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.06.15.21254693", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-06-17T07:51:05.519Z", "modified": "2023-06-19T14:11:58.638Z"}, {"entity": "publication", "iuid": "d94670e1580f4e05bc5b84b85be4eba7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d94670e1580f4e05bc5b84b85be4eba7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d94670e1580f4e05bc5b84b85be4eba7"}}, "title": "SARS-CoV-2 antigen testing: weighing the false positives against the costs of failing to control transmission.", "authors": [{"family": "Fearon", "given": "Elizabeth", "initials": "E"}, {"family": "Buchan", "given": "Iain E", "initials": "IE"}, {"family": "Das", "given": "Rajenki", "initials": "R"}, {"family": "Davis", "given": "Emma L", "initials": "EL"}, {"family": "Fyles", "given": "Martyn", "initials": "M"}, {"family": "Hall", "given": "Ian", "initials": "I"}, {"family": "Hollingsworth", "given": "T Deirdre", "initials": "TD"}, {"family": "House", "given": "Thomas", "initials": "T"}, {"family": "Jay", "given": "Caroline", "initials": "C"}, {"family": "Medley", "given": "Graham F", "initials": "GF"}, {"family": "Pellis", "given": "Lorenzo", "initials": "L"}, {"family": "Quilty", "given": "Billy J", "initials": "BJ"}, {"family": "Silva", "given": "Miguel E P", "initials": "MEP"}, {"family": "Stage", "given": "Helena B", "initials": "HB"}, {"family": "Wingfield", "given": "Tom", "initials": "T"}], "type": "journal article", "published": "2021-06-14", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "issn-l": "2213-2600", "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/S2213-2600(21)00234-4", "pmid": "34139150", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Proteins": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(21)00234-4"}, {"db": "pmc", "key": "PMC8203180"}], "notes": [], "created": "2021-06-28T18:38:00.383Z", "modified": "2021-06-28T18:38:15.256Z"}, {"entity": "publication", "iuid": "83359ec64ced454083ee5d1daa70968e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/83359ec64ced454083ee5d1daa70968e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/83359ec64ced454083ee5d1daa70968e"}}, "title": "Quality of web-based information at the beginning of a global pandemic: a cross-sectional infodemiology study investigating preventive measures and self care methods of the coronavirus disease 2019.", "authors": [{"family": "Stern", "given": "Jenny", "initials": "J"}, {"family": "Georgsson", "given": "Susanne", "initials": "S"}, {"family": "Carlsson", "given": "Tommy", "initials": "T"}], "type": "journal article", "published": "2021-06-14", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "1141"}, "abstract": "reducing the spread and impact epidemics and pandemics requires that members of the general population change their behaviors according to the recommendations, restrictions and laws provided by leading authorities. When a new epidemic or pandemic emerges, people are faced with the challenge of sorting through a great volume of varied information. Therefore, the dissemination of high-quality web-based information is essential during this time period. The overarching aim was to investigate the quality of web-based information about preventive measures and self care methods at the beginning of the COVID-19 pandemic.\r\n\r\nin May 2020, consumer-oriented websites written in Swedish were identified via systematic searches in Google (n = 76). Websites were assessed with inductive content analysis, the JAMA benchmarks, the QUEST tool and the DISCERN instrument.\r\n\r\nseven categories and 33 subcategories were identified concerning preventive measures (md = 6.0 subcategories), with few specifying a method for washing hands (n = 4), when to sanitize the hands (n = 4), and a method for sanitizing the hands (n = 1). Eight categories and 30 subcategories were identified concerning self care methods (md = 3.0 subcategories), with few referring to the national number for telephone-based counseling (n = 20) and an online symptom assessment tool (n = 16). Overall, the median total quality scores were low (JAMA = 0/4, QUEST =13/28, DISCERN = 29/80).\r\n\r\nat the beginning of the pandemic, substantial quality deficits of websites about COVID-19 may have counteracted the public recommendations for preventive measures. This illustrates a critical need for standardized and systematic routines on how to achieve dissemination of high-quality web-based information when new epidemics and pandemics emerge.", "doi": "10.1186/s12889-021-11141-9", "pmid": "34126962", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11141-9"}], "notes": [], "created": "2021-06-17T07:45:13.842Z", "modified": "2021-07-14T10:43:17.935Z"}, {"entity": "publication", "iuid": "6a76f804003d4811a92d215d7bebb1d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a76f804003d4811a92d215d7bebb1d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a76f804003d4811a92d215d7bebb1d7"}}, "title": "Internet-Based Cognitive Behavioral Therapy for Psychological Distress Associated With the COVID-19 Pandemic: A Pilot Randomized Controlled Trial.", "authors": [{"family": "Aminoff", "given": "Victoria", "initials": "V"}, {"family": "Sell\u00e9n", "given": "Malin", "initials": "M"}, {"family": "S\u00f6rliden", "given": "Elise", "initials": "E"}, {"family": "Ludvigsson", "given": "Mikael", "initials": "M"}, {"family": "Berg", "given": "Matilda", "initials": "M"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}], "type": "journal article", "published": "2021-06-14", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "pages": "684540", "issn-l": "1664-1078"}, "abstract": "Background: The COVID-19 pandemic has been associated with various negative psychological consequences. This is a challenge for the society as regular psychological services cannot be offered to the same extent as before the pandemic. In addition to the requirement of social distancing, there is a need to adjust psychological treatment components like exposure to avoid increasing the spread of the infection. Internet-delivered cognitive behavior therapy (ICBT) has an established evidence base for a range of psychiatric problems and has been suggested as one possible approach to deal with the situation. This study aimed to conduct a randomized controlled pilot trial during the summer of 2020 with a broad focus on psychological distress and a treatment approach that tailors the intervention based on symptom profile and preferences. Methods: Following the advertisement and interview, we included 52 participants with elevated levels of psychological distress. They were randomly allocated to either a 7-week-long individually tailored ICBT (n = 26) or a wait-list control condition (n = 26). Measures of depression and quality of life were used as primary outcomes. We also included secondary outcome measures of anxiety, insomnia, trauma, stress, anger, and alcohol use. For screening, we used the CoRonavIruS Health Impact Survey (CRISIS). Results: Overall moderate to large between-group effects were found at post-treatment in favor of the treatment on measures of both depression [Beck Depression Inventory (BDI); Cohens d = 0.63; Patient Health Questionnaire (PHQ-9): d = 0.62] and anxiety [Generalized Anxiety Disorder-7-item scale (GAD-7); d = 0.82]. This was also observed for stress symptoms [Perceived Stress Scale (PSS-14); d = 1.04]. No effects were seen on measures of quality of life, insomnia, symptoms of post-traumatic stress, and anger. There was an effect on alcohol use [Alcohol Use Disorder Identification Test (AUDIT); d = 0.54], which was not of clinical relevance. Conclusion: Individually tailored ICBT shows initial promise as a way to reduce psychological problems in association with the COVID-19 pandemic. A possible limitation was that the trial was conducted when the effects of the pandemic were decreasing and when fewer people were affected by the restrictions (e.g., the summer of 2020).", "doi": "10.3389/fpsyg.2021.684540", "pmid": "34194374", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8236879"}], "notes": [], "created": "2021-07-05T14:30:27.245Z", "modified": "2021-07-05T14:30:27.258Z"}, {"entity": "publication", "iuid": "66daaaac6fb74d54bbdeb2514441f642", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66daaaac6fb74d54bbdeb2514441f642.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66daaaac6fb74d54bbdeb2514441f642"}}, "title": "Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19: the PROFLO multicenter randomized clinical trial.", "authors": [{"family": "Ros\u00e9n", "given": "Jacob", "initials": "J", "orcid": "0000-0001-9518-5834", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ce3d5b2cb914d72bbd476b7e1127c8d.json"}}, {"family": "von Oelreich", "given": "Erik", "initials": "E"}, {"family": "Fors", "given": "Diddi", "initials": "D"}, {"family": "Jonsson Fagerlund", "given": "Malin", "initials": "M"}, {"family": "Taxbro", "given": "Knut", "initials": "K"}, {"family": "Skorup", "given": "Paul", "initials": "P"}, {"family": "Eby", "given": "Ludvig", "initials": "L"}, {"family": "Campoccia Jalde", "given": "Francesca", "initials": "F"}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Bergstr\u00f6m", "given": "Gustav", "initials": "G"}, {"family": "Frykholm", "given": "Peter", "initials": "P"}, {"family": "PROFLO Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-06-14", "journal": {"title": "Crit Care", "issn": "1466-609X", "volume": "25", "issue": "1", "pages": "209", "issn-l": "1364-8535"}, "abstract": "The effect of awake prone positioning on intubation rates is not established. The aim of this trial was to investigate if a protocol for awake prone positioning reduces the rate of endotracheal intubation compared with standard care among patients with moderate to severe hypoxemic respiratory failure due to COVID-19.\n\nWe conducted a multicenter randomized clinical trial. Adult patients with confirmed COVID-19, high-flow nasal oxygen or noninvasive ventilation for respiratory support and a PaO 2/FiO2 ratio \u2264 20 kPa were randomly assigned to a protocol targeting 16 h prone positioning per day or standard care. The primary endpoint was intubation within 30 days. Secondary endpoints included duration of awake prone positioning, 30-day mortality, ventilator-free days, hospital and intensive care unit length of stay, use of noninvasive ventilation, organ support and adverse events. The trial was terminated early due to futility.\n\nOf 141 patients assessed for eligibility, 75 were randomized of whom 39 were allocated to the control group and 36 to the prone group. Within 30 days after enrollment, 13 patients (33%) were intubated in the control group versus 12 patients (33%) in the prone group (HR 1.01 (95% CI 0.46-2.21), P = 0.99). Median prone duration was 3.4 h [IQR 1.8-8.4] in the control group compared with 9.0 h per day [IQR 4.4-10.6] in the prone group (P = 0.014). Nine patients (23%) in the control group had pressure sores compared with two patients (6%) in the prone group (difference - 18% (95% CI - 2 to - 33%); P = 0.032). There were no other differences in secondary outcomes between groups.\n\nThe implemented protocol for awake prone positioning increased duration of prone positioning, but did not reduce the rate of intubation in patients with hypoxemic respiratory failure due to COVID-19 compared to standard care.\n\nISRCTN54917435. Registered 15 June 2020 ( https://doi.org/10.1186/ISRCTN54917435 ).", "doi": "10.1186/s13054-021-03602-9", "pmid": "34127046", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-021-03602-9"}], "notes": [], "created": "2021-06-17T07:46:39.730Z", "modified": "2021-06-17T07:46:39.756Z"}, {"entity": "publication", "iuid": "fd6568a926674a8cb267ba9af3f57b03", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fd6568a926674a8cb267ba9af3f57b03.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fd6568a926674a8cb267ba9af3f57b03"}}, "title": "A time-resolved proteomic and prognostic map of COVID-19.", "authors": [{"family": "Demichev", "given": "Vadim", "initials": "V"}, {"family": "Tober-Lau", "given": "Pinkus", "initials": "P"}, {"family": "Lemke", "given": "Oliver", "initials": "O"}, {"family": "Nazarenko", "given": "Tatiana", "initials": "T"}, {"family": "Thibeault", "given": "Charlotte", "initials": "C"}, {"family": "Whitwell", "given": "Harry", "initials": "H"}, {"family": "R\u00f6hl", "given": "Annika", "initials": "A"}, {"family": "Freiwald", "given": "Anja", "initials": "A"}, {"family": "Szyrwiel", "given": "Lukasz", "initials": "L"}, {"family": "Ludwig", "given": "Daniela", "initials": "D"}, {"family": "Correia-Melo", "given": "Clara", "initials": "C"}, {"family": "Aulakh", "given": "Simran Kaur", "initials": "SK"}, {"family": "Helbig", "given": "Elisa T", "initials": "ET"}, {"family": "Stubbemann", "given": "Paula", "initials": "P"}, {"family": "Lippert", "given": "Lena J", "initials": "LJ"}, {"family": "Gr\u00fcning", "given": "Nana-Maria", "initials": "N"}, {"family": "Blyuss", "given": "Oleg", "initials": "O"}, {"family": "Vernardis", "given": "Spyros", "initials": "S"}, {"family": "White", "given": "Matthew", "initials": "M"}, {"family": "Messner", "given": "Christoph B", "initials": "CB"}, {"family": "Joannidis", "given": "Michael", "initials": "M"}, {"family": "Sonnweber", "given": "Thomas", "initials": "T"}, {"family": "Klein", "given": "Sebastian J", "initials": "SJ"}, {"family": "Pizzini", "given": "Alex", "initials": "A"}, {"family": "Wohlfarter", "given": "Yvonne", "initials": "Y"}, {"family": "Sahanic", "given": "Sabina", "initials": "S"}, {"family": "Hilbe", "given": "Richard", "initials": "R"}, {"family": "Schaefer", "given": "Benedikt", "initials": "B"}, {"family": "Wagner", "given": "Sonja", "initials": "S"}, {"family": "Mittermaier", "given": "Mirja", "initials": "M"}, {"family": "Machleidt", "given": "Felix", "initials": "F"}, {"family": "Garcia", "given": "Carmen", "initials": "C"}, {"family": "Ruwwe-Gl\u00f6senkamp", "given": "Christoph", "initials": "C"}, {"family": "Lingscheid", "given": "Tilman", "initials": "T"}, {"family": "Bosquillon de Jarcy", "given": "Laure", "initials": "L"}, {"family": "Stegemann", "given": "Miriam S", "initials": "MS"}, {"family": "Pfeiffer", "given": "Moritz", "initials": "M"}, {"family": "J\u00fcrgens", "given": "Linda", "initials": "L"}, {"family": "Denker", "given": "Sophy", "initials": "S"}, {"family": "Zickler", "given": "Daniel", "initials": "D"}, {"family": "Enghard", "given": "Philipp", "initials": "P"}, {"family": "Zelezniak", "given": "Aleksej", "initials": "A"}, {"family": "Campbell", "given": "Archie", "initials": "A"}, {"family": "Hayward", "given": "Caroline", "initials": "C"}, {"family": "Porteous", "given": "David J", "initials": "DJ"}, {"family": "Marioni", "given": "Riccardo E", "initials": "RE"}, {"family": "Uhrig", "given": "Alexander", "initials": "A"}, {"family": "M\u00fcller-Redetzky", "given": "Holger", "initials": "H"}, {"family": "Zoller", "given": "Heinz", "initials": "H"}, {"family": "L\u00f6ffler-Ragg", "given": "Judith", "initials": "J"}, {"family": "Keller", "given": "Markus A", "initials": "MA"}, {"family": "Tancevski", "given": "Ivan", "initials": "I"}, {"family": "Timms", "given": "John F", "initials": "JF"}, {"family": "Zaikin", "given": "Alexey", "initials": "A"}, {"family": "Hippenstiel", "given": "Stefan", "initials": "S"}, {"family": "Ramharter", "given": "Michael", "initials": "M"}, {"family": "Witzenrath", "given": "Martin", "initials": "M"}, {"family": "Suttorp", "given": "Norbert", "initials": "N"}, {"family": "Lilley", "given": "Kathryn", "initials": "K"}, {"family": "M\u00fclleder", "given": "Michael", "initials": "M"}, {"family": "Sander", "given": "Leif Erik", "initials": "LE"}, {"family": "PA-COVID-19 Study group", "given": "", "initials": ""}, {"family": "Ralser", "given": "Markus", "initials": "M"}, {"family": "Kurth", "given": "Florian", "initials": "F"}], "type": "journal article", "published": "2021-06-14", "journal": {"title": "Cell Syst", "issn": "2405-4720", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. We characterized the time-dependent progression of the disease in 139 COVID-19 inpatients by measuring 86 accredited diagnostic parameters, such as blood cell counts and enzyme activities, as well as untargeted plasma proteomes at 687 sampling points. We report an initial spike in a systemic inflammatory response, which is gradually alleviated and followed by a protein signature indicative of tissue repair, metabolic reconstitution, and immunomodulation. We identify prognostic marker signatures for devising risk-adapted treatment strategies and use machine learning to classify therapeutic needs. We show that the machine learning models based on the proteome are transferable to an independent cohort. Our study presents a map linking routinely used clinical diagnostic parameters to plasma proteomes and their dynamics in an infectious disease.", "doi": "10.1016/j.cels.2021.05.005", "pmid": "34139154", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S2405-4712(21)00160-5"}, {"db": "pmc", "key": "PMC8201874"}], "notes": [], "created": "2021-06-28T18:35:54.366Z", "modified": "2021-06-30T05:12:43.763Z"}, {"entity": "publication", "iuid": "18f851e21f6d4ea4b5bd88550870048c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18f851e21f6d4ea4b5bd88550870048c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18f851e21f6d4ea4b5bd88550870048c"}}, "title": "SARS-CoV-2 spike protein removes lipids from model membranes and interferes with the capacity of high density lipoprotein to exchange lipids.", "authors": [{"family": "Correa", "given": "Yubexi", "initials": "Y"}, {"family": "Waldie", "given": "Sarah", "initials": "S"}, {"family": "Th\u00e9paut", "given": "Michel", "initials": "M"}, {"family": "Micciula", "given": "Samantha", "initials": "S"}, {"family": "Moulin", "given": "Martine", "initials": "M"}, {"family": "Fieschi", "given": "Franck", "initials": "F"}, {"family": "Pichler", "given": "Harald", "initials": "H"}, {"family": "Trevor Forsyth", "given": "V", "initials": "V"}, {"family": "Haertlein", "given": "Michael", "initials": "M"}, {"family": "C\u00e1rdenas", "given": "Marit\u00e9", "initials": "M"}], "type": "journal article", "published": "2021-06-12", "journal": {"title": "J Colloid Interface Sci", "issn": "1095-7103", "issn-l": null, "volume": "602", "issue": null, "pages": "732-739"}, "abstract": "Cholesterol has been shown to affect the extent of coronavirus binding and fusion to cellular membranes. The severity of Covid-19 infection is also known to be correlated with lipid disorders. Furthermore, the levels of both serum cholesterol and high-density lipoprotein (HDL) decrease with Covid-19 severity, with normal levels resuming once the infection has passed. Here we demonstrate that the SARS-CoV-2 spike (S) protein interferes with the function of lipoproteins, and that this is dependent on cholesterol. In particular, the ability of HDL to exchange lipids from model cellular membranes is altered when co-incubated with the spike protein. Additionally, the S protein removes lipids and cholesterol from model membranes. We propose that the S protein affects HDL function by removing lipids from it and remodelling its composition/structure.", "doi": "10.1016/j.jcis.2021.06.056", "pmid": "34157514", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S0021-9797(21)00930-9"}, {"db": "pmc", "key": "PMC8195693"}], "notes": [], "created": "2021-06-28T18:20:09.531Z", "modified": "2021-06-28T18:21:11.283Z"}, {"entity": "publication", "iuid": "e88362b5f2fc485c865d6d25f77f54cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e88362b5f2fc485c865d6d25f77f54cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e88362b5f2fc485c865d6d25f77f54cc"}}, "title": "Decreased Mortality Over Time During the First Wave in Patients With COVID-19 in Geriatric Care: Data From the Stockholm GeroCovid Study.", "authors": [{"family": "Xu", "given": "Hong", "initials": "H"}, {"family": "Garcia-Ptacek", "given": "Sara", "initials": "S"}, {"family": "Annetorp", "given": "Martin", "initials": "M"}, {"family": "Cederholm", "given": "Tommy", "initials": "T"}, {"family": "Engel", "given": "Georg", "initials": "G"}, {"family": "Engstr\u00f6m", "given": "Malin", "initials": "M"}, {"family": "Erlandsson", "given": "H\u00e5kan", "initials": "H"}, {"family": "Julius", "given": "Charlotte", "initials": "C"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Lundberg", "given": "Lars G\u00f6ran", "initials": "LG"}, {"family": "Metzner", "given": "Carina", "initials": "C"}, {"family": "Sandberg", "given": "Linda", "initials": "L"}, {"family": "Nyvang", "given": "Josefina Skog\u00f6", "initials": "JS"}, {"family": "\u00d6berg", "given": "Carina S\u00fchl", "initials": "CS"}, {"family": "\u00c5kesson", "given": "Elisabet", "initials": "E"}, {"family": "Religa", "given": "Dorota", "initials": "D"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-06-12", "journal": {"title": "J Am Med Dir Assoc", "issn": "1538-9375", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To describe temporal changes in treatment, care, and short-term mortality outcomes of geriatric patients during the first wave of the COVID-19 pandemic.\r\n\r\nObservational study.\r\n\r\nAltogether 1785 patients diagnosed with COVID-19 and 6744 hospitalized for non-COVID-19 causes at 7 geriatric clinics in Stockholm from March 6 to July 31, 2020, were included.\r\n\r\nAcross admission month, patient vital signs and pharmacological treatment in relationship to risk for in-hospital death were analyzed using the Poisson regression model. Incidence rates (IRs) and incidence rate ratios (IRRs) of death are presented.\r\n\r\nIn patients with COVID-19, the IR of mortality were 27%, 17%, 10%, 8%, and 2% from March to July, respectively, after standardization for demographics and vital signs. Compared with patients admitted in March, the risk of in-hospital death decreased by 29% [IRR 0.71, 95% confidence interval (CI) 0.51-0.99] in April, 61% (0.39, 0.26-0.58) in May, 68% (0.32, 0.19-0.55) in June, and 86% (0.14, 0.03-0.58) in July. The proportion of patients admitted for geriatric care with oxygen saturation <90% decreased from 13% to 1%, which partly explains the improvement of COVID-19 patient survival. In non-COVID-19 patients during the pandemic, mortality rates remained relatively stable (IR 1.3%-2.3%). Compared with non-COVID-19 geriatric patients, the IRR of death declined from 11 times higher (IRR 11.7, 95% CI 6.11-22.3) to 1.6 times (2.61, 0.50-13.7) between March and July in patients with COVID-19.\r\n\r\nMortality risk in geriatric patients from the Stockholm region declined over time throughout the first pandemic wave of COVID-19. The improved survival rate over time was only partly related to improvement in saturation status at the admission of the patients hospitalized later throughout the pandemic. Lower incidence during the later months could have led to less severe hospitalized cases driving down mortality.", "doi": "10.1016/j.jamda.2021.06.005", "pmid": "34216553", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1525-8610(21)00554-5"}], "notes": [], "created": "2021-07-05T15:02:15.808Z", "modified": "2021-07-14T10:42:45.179Z"}, {"entity": "publication", "iuid": "10fa73a458484d42bf0e15088c099fb3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/10fa73a458484d42bf0e15088c099fb3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/10fa73a458484d42bf0e15088c099fb3"}}, "title": "Consequences of visiting restrictions during the COVID-19 pandemic: An integrative review.", "authors": [{"family": "Hugelius", "given": "Karin", "initials": "K"}, {"family": "Harada", "given": "Nahoko", "initials": "N"}, {"family": "Marutani", "given": "Miki", "initials": "M"}], "type": "journal article", "published": "2021-06-12", "journal": {"title": "Int J Nurs Stud", "issn": "1873-491X", "volume": "121", "pages": "104000", "issn-l": null}, "abstract": "During the COVID-19 pandemic, visiting restrictions of different extents have been implemented. However, despite the long history of visiting restrictions in health care systems, little is known about their effects.\n\nThis review sought to explore the consequences of visitor restrictions in health care services during the COVID-19 pandemic.\n\nA systematic, integrative review was conducted in accordance with the PRISMA guidelines, based on a systematic search in PubMed, CHINAL full plus, Web of Science, PsychInfo, Scopus and the Cochrane Library.\n\nA total of 17 scientific papers covering intensive care, pediatric care, general medical care, hospital care, palliative care and nursing home settings were included. Although appreciation for the technical solutions enabling remote meetings was reported, visiting restrictions had several consequences, mainly negative, for the patient's health, the health and wellbeing of family members and the provision of care. Among physical health consequences, reduced nutrition intake, decreased activities of daily living and increased physical pain and symptoms were reported. Among mental health consequences for the patient, loneliness, depressive symptoms, agitation, aggression, reduced cognitive ability and overall dissatisfaction were observed. For family members, worry, anxiety and uncertainty occurred, and they reported an increased need for information from care providers. Family members of neonatal intensive care unit patients reported less bonding with their child and family relation disturbances due to the restrictions. For care providers, visiting restrictions added the burdens of ethical dilemmas, learning new technical means to enable social interaction and an increased demand for communication with families and providing social support to both family members and patients.\n\nWhen implementing visiting restrictions in health care services, decision makers and nurses need to be aware of their potential negative effects and adapt the provision of care to compensate for such effects. Nurses in all sectors should be aware that visiting restrictions may affect patients, families, and health care services for longer than the actual pandemic. Since the level of evidence regarding effect from visiting restrictions is low, further studies is strongly needed.", "doi": "10.1016/j.ijnurstu.2021.104000", "pmid": "34242976", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0020-7489(21)00147-4"}, {"db": "pmc", "key": "PMC8196532"}], "notes": [], "created": "2021-08-06T07:57:55.486Z", "modified": "2021-08-06T07:57:55.509Z"}, {"entity": "publication", "iuid": "a4b68701383d467f979b00c17c6ae119", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a4b68701383d467f979b00c17c6ae119.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a4b68701383d467f979b00c17c6ae119"}}, "title": "Profiling Human CMV-specific T cell responses reveals novel immunogenic ORFs", "authors": [{"family": "Dhanwani", "given": "Rekha", "initials": "R", "orcid": "0000-0002-6592-8657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d61c1971458d49e0888b29976e0a3893.json"}}, {"family": "Dhanda", "given": "Sandeep Kumar", "initials": "SK"}, {"family": "Pham", "given": "John", "initials": "J"}, {"family": "Williams", "given": "Gregory P", "initials": "GP"}, {"family": "Sidney", "given": "John", "initials": "J"}, {"family": "Grifoni", "given": "Alba", "initials": "A", "orcid": "0000-0002-2209-5966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2cbbaebec64e41289979d55aed0b0ad4.json"}}, {"family": "Picarda", "given": "Gaelle", "initials": "G"}, {"family": "Lindestam Arlehamn", "given": "Cecilia S", "initials": "CS"}, {"family": "Sette", "given": "Alessandro", "initials": "A"}, {"family": "Benedict", "given": "Chris A", "initials": "CA"}], "type": "posted-content", "published": "2021-06-11", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.06.10.447997", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-06-14T14:52:49.944Z", "modified": "2023-06-19T15:22:57.372Z"}, {"entity": "publication", "iuid": "bfa777673501494b873a86821c2f9a30", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bfa777673501494b873a86821c2f9a30.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bfa777673501494b873a86821c2f9a30"}}, "title": "Natural killer cells in antiviral immunity.", "authors": [{"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Strunz", "given": "Benedikt", "initials": "B"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}], "type": "journal article", "published": "2021-06-11", "journal": {"title": "Nat Rev Immunol", "issn": "1474-1741", "issn-l": "1474-1733", "volume": null, "issue": null, "pages": null}, "abstract": "Natural killer (NK) cells play an important role in innate immune responses to viral infections. Here, we review recent insights into the role of NK cells in viral infections, with particular emphasis on human studies. We first discuss NK cells in the context of acute viral infections, with flavivirus and influenza virus infections as examples. Questions related to activation of NK cells, homing to infected tissues and the role of tissue-resident NK cells in acute viral infections are also addressed. Next, we discuss NK cells in the context of chronic viral infections with hepatitis C virus and HIV-1. Also covered is the role of adaptive-like NK cell expansions as well as the appearance of CD56 - NK cells in the course of chronic infection. Specific emphasis is then placed in viral infections in patients with primary immunodeficiencies affecting NK cells. Not least, studies in this area have revealed an important role for NK cells in controlling several herpesvirus infections. Finally, we address new data with respect to the activation of NK cells and NK cell function in humans infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) giving rise to coronavirus disease 2019 (COVID-19).", "doi": "10.1038/s41577-021-00558-3", "pmid": "34117484", "labels": {"Type: Review": null, "Funder: H2020": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41577-021-00558-3"}], "notes": [], "created": "2021-06-14T06:31:09.794Z", "modified": "2021-06-14T06:32:50.189Z"}, {"entity": "publication", "iuid": "fa45de1635df45478ddcbcc3953153c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa45de1635df45478ddcbcc3953153c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa45de1635df45478ddcbcc3953153c5"}}, "title": "Mental Health of Refugees and Migrants during the COVID-19 Pandemic: The Role of Experienced Discrimination and Daily Stressors.", "authors": [{"family": "Spiritus-Beerden", "given": "Eva", "initials": "E", "orcid": "0000-0003-2312-8034", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/515f6b3d01664e988fefe0a5344ce7c9.json"}}, {"family": "Verelst", "given": "An", "initials": "A", "orcid": "0000-0002-7178-643X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fbcb257027514818993b0318a7c513bf.json"}}, {"family": "Devlieger", "given": "Ines", "initials": "I"}, {"family": "Langer Primdahl", "given": "Nina", "initials": "N"}, {"family": "Botelho Guedes", "given": "F\u00e1bio", "initials": "F"}, {"family": "Chiarenza", "given": "Antonio", "initials": "A"}, {"family": "De Maesschalck", "given": "Stephanie", "initials": "S"}, {"family": "Durbeej", "given": "Natalie", "initials": "N"}, {"family": "Garrido", "given": "Roc\u00edo", "initials": "R", "orcid": "0000-0002-2238-0222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa02e7e75daf40c79c429493d506693b.json"}}, {"family": "Gaspar de Matos", "given": "Margarida", "initials": "M"}, {"family": "Ioannidi", "given": "Elisabeth", "initials": "E"}, {"family": "Murphy", "given": "Rebecca", "initials": "R"}, {"family": "Oulahal", "given": "Rachid", "initials": "R", "orcid": "0000-0002-9120-0512", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb7a43d0144541ad9598f666f28e0564.json"}}, {"family": "Osman", "given": "Fatumo", "initials": "F"}, {"family": "Padilla", "given": "Beatriz", "initials": "B"}, {"family": "Paloma", "given": "Virginia", "initials": "V", "orcid": "0000-0002-0707-1982", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f9661fbebe54eb6971d4e2644d487cd.json"}}, {"family": "Shehadeh", "given": "Amer", "initials": "A"}, {"family": "Sturm", "given": "Gesine", "initials": "G"}, {"family": "van den Muijsenbergh", "given": "Maria", "initials": "M"}, {"family": "Vasilikou", "given": "Katerina", "initials": "K"}, {"family": "Watters", "given": "Charles", "initials": "C"}, {"family": "Willems", "given": "Sara", "initials": "S", "orcid": "0000-0002-6349-7785", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a066fe07ba24b948a9ad37dc2db7a8d.json"}}, {"family": "Skovdal", "given": "Morten", "initials": "M"}, {"family": "Derluyn", "given": "Ilse", "initials": "I"}], "type": "journal article", "published": "2021-06-11", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "12", "pages": "6354"}, "abstract": "The COVID-19 pandemic is a defining global health crisis of our time. While the impact of COVID-19, including its mental health impact, is increasingly being documented, there remain important gaps regarding the specific consequences of the pandemic on particular population groups, including refugees and migrants. This study aims to uncover the impact of the COVID-19 pandemic on the mental health of refugees and migrants worldwide, disentangling the possible role of social and daily stressors, i.e., experiences of discrimination and daily living conditions. Descriptive analysis and structural equation modeling were used to analyze the responses of N = 20,742 refugees and migrants on the self-reporting global ApartTogether survey. Survey findings indicated that the mental health of refugees and migrants during the COVID-19 pandemic was significantly impacted, particularly for certain subgroups, (i.e., insecure housing situation and residence status, older respondents, and females) who reported experiencing higher levels of increased discrimination and increases in daily life stressors. There is a need to recognize the detrimental mental health impact of the COVID-19 pandemic on particular refugee and migrant groups and to develop interventions that target their unique needs.", "doi": "10.3390/ijerph18126354", "pmid": "34208243", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8296172"}, {"db": "pii", "key": "ijerph18126354"}], "notes": [], "created": "2021-07-05T14:44:02.414Z", "modified": "2023-06-19T14:49:46.737Z"}, {"entity": "publication", "iuid": "3106c8dfdbef48e9a634dbdcc99c2b58", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3106c8dfdbef48e9a634dbdcc99c2b58.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3106c8dfdbef48e9a634dbdcc99c2b58"}}, "title": "Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection.", "authors": [{"family": "Koenecke", "given": "Allison", "initials": "A", "orcid": "0000-0002-6233-8256", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df3eeaa979c5401a9e335cc2de290ddd.json"}}, {"family": "Powell", "given": "Michael", "initials": "M", "orcid": "0000-0003-2749-3725", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8f4a79115a0471b9bcc099f3af2e4c7.json"}}, {"family": "Xiong", "given": "Ruoxuan", "initials": "R"}, {"family": "Shen", "given": "Zhu", "initials": "Z"}, {"family": "Fischer", "given": "Nicole", "initials": "N"}, {"family": "Huq", "given": "Sakibul", "initials": "S"}, {"family": "Khalafallah", "given": "Adham M", "initials": "AM"}, {"family": "Trevisan", "given": "Marco", "initials": "M"}, {"family": "Sparen", "given": "P\u00e4r", "initials": "P", "orcid": "0000-0002-5184-8971", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5f390813419444091c61e211c442c6f.json"}}, {"family": "Carrero", "given": "Juan J", "initials": "JJ"}, {"family": "Nishimura", "given": "Akihiko", "initials": "A"}, {"family": "Caffo", "given": "Brian", "initials": "B"}, {"family": "Stuart", "given": "Elizabeth A", "initials": "EA"}, {"family": "Bai", "given": "Renyuan", "initials": "R"}, {"family": "Staedtke", "given": "Verena", "initials": "V"}, {"family": "Thomas", "given": "David L", "initials": "DL"}, {"family": "Papadopoulos", "given": "Nickolas", "initials": "N"}, {"family": "Kinzler", "given": "Ken W", "initials": "KW"}, {"family": "Vogelstein", "given": "Bert", "initials": "B"}, {"family": "Zhou", "given": "Shibin", "initials": "S"}, {"family": "Bettegowda", "given": "Chetan", "initials": "C"}, {"family": "Konig", "given": "Maximilian F", "initials": "MF", "orcid": "0000-0001-5045-5255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/41b9c2c9bca54637959496d449b5aa31.json"}}, {"family": "Mensh", "given": "Brett D", "initials": "BD"}, {"family": "Vogelstein", "given": "Joshua T", "initials": "JT", "orcid": "0000-0003-2487-6237", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cb459c056f1f46c28961552ea5180972.json"}}, {"family": "Athey", "given": "Susan", "initials": "S"}], "type": "journal article", "published": "2021-06-11", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "10", "issn-l": null}, "abstract": "In severe viral pneumonia, including Coronavirus disease 2019 (COVID-19), the viral replication phase is often followed by hyperinflammation, which can lead to acute respiratory distress syndrome, multi-organ failure, and death. We previously demonstrated that alpha-1 adrenergic receptor (\u237a 1-AR) antagonists can prevent hyperinflammation and death in mice. Here, we conducted retrospective analyses in two cohorts of patients with acute respiratory distress (ARD, n = 18,547) and three cohorts with pneumonia (n = 400,907). Federated across two ARD cohorts, we find that patients exposed to \u237a1-AR antagonists, as compared to unexposed patients, had a 34% relative risk reduction for mechanical ventilation and death (OR = 0.70, p = 0.021). We replicated these methods on three pneumonia cohorts, all with similar effects on both outcomes. All results were robust to sensitivity analyses. These results highlight the urgent need for prospective trials testing whether prophylactic use of \u237a1-AR antagonists ameliorates lower respiratory tract infection-associated hyperinflammation and death, as observed in COVID-19.", "doi": "10.7554/eLife.61700", "pmid": "34114951", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "61700"}], "notes": [], "created": "2021-06-14T06:34:58.781Z", "modified": "2021-06-14T06:35:13.702Z"}, {"entity": "publication", "iuid": "d1b262f8c4874505b7bbf24f302fe1cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1b262f8c4874505b7bbf24f302fe1cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1b262f8c4874505b7bbf24f302fe1cc"}}, "title": "A Blueprint for High Affinity SARS-CoV-2 Mpro Inhibitors from Activity-Based Compound Library Screening Guided by Analysis of Protein Dynamics.", "authors": [{"family": "Gossen", "given": "Jonas", "initials": "J", "orcid": "0000-0002-0730-6796", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0f7e23c127404ca1bea9151bd20030a5.json"}}, {"family": "Albani", "given": "Simone", "initials": "S"}, {"family": "Hanke", "given": "Anton", "initials": "A"}, {"family": "Joseph", "given": "Benjamin P", "initials": "BP"}, {"family": "Bergh", "given": "Cathrine", "initials": "C"}, {"family": "Kuzikov", "given": "Maria", "initials": "M", "orcid": "0000-0001-8771-1865", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fcbffac44a748028611a74f2678d8f9.json"}}, {"family": "Costanzi", "given": "Elisa", "initials": "E"}, {"family": "Manelfi", "given": "Candida", "initials": "C"}, {"family": "Storici", "given": "Paola", "initials": "P"}, {"family": "Gribbon", "given": "Philip", "initials": "P"}, {"family": "Beccari", "given": "Andrea R", "initials": "AR"}, {"family": "Talarico", "given": "Carmine", "initials": "C"}, {"family": "Spyrakis", "given": "Francesca", "initials": "F", "orcid": "0000-0002-4016-227X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa1e7500ff8a4440bb7058bcf55c9e4d.json"}}, {"family": "Lindahl", "given": "Erik", "initials": "E"}, {"family": "Zaliani", "given": "Andrea", "initials": "A", "orcid": "0000-0002-1740-8390", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a9e31a5fa26f4e69a0815d1443d3ffc9.json"}}, {"family": "Carloni", "given": "Paolo", "initials": "P", "orcid": "0000-0002-9010-0149", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0729cca0143c4847a104475ba5354f94.json"}}, {"family": "Wade", "given": "Rebecca C", "initials": "RC", "orcid": "0000-0001-5951-8670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b13317434734da2a15ec2d4ba4d421d.json"}}, {"family": "Musiani", "given": "Francesco", "initials": "F", "orcid": "0000-0003-0200-1712", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5e6a98e63ce4cbfaf5a3da8cc777485.json"}}, {"family": "Kokh", "given": "Daria B", "initials": "DB", "orcid": "0000-0002-4687-6572", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e00f108ee7f4fa58625e61548fea8db.json"}}, {"family": "Rossetti", "given": "Giulia", "initials": "G", "orcid": "0000-0002-2032-4630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/901dadea04014dc88651e5a711325fa8.json"}}], "type": "journal article", "published": "2021-06-11", "journal": {"title": "ACS Pharmacol. Transl. Sci.", "issn": "2575-9108", "volume": "4", "issue": "3", "pages": "1079-1095", "issn-l": null}, "abstract": "The SARS-CoV-2 coronavirus outbreak continues to spread at a rapid rate worldwide. The main protease (Mpro) is an attractive target for anti-COVID-19 agents. Unexpected difficulties have been encountered in the design of specific inhibitors. Here, by analyzing an ensemble of \u223c30 000 SARS-CoV-2 Mpro conformations from crystallographic studies and molecular simulations, we show that small structural variations in the binding site dramatically impact ligand binding properties. Hence, traditional druggability indices fail to adequately discriminate between highly and poorly druggable conformations of the binding site. By performing \u223c200 virtual screenings of compound libraries on selected protein structures, we redefine the protein's druggability as the consensus chemical space arising from the multiple conformations of the binding site formed upon ligand binding. This procedure revealed a unique SARS-CoV-2 Mpro blueprint that led to a definition of a specific structure-based pharmacophore. The latter explains the poor transferability of potent SARS-CoV Mpro inhibitors to SARS-CoV-2 Mpro, despite the identical sequences of the active sites. Importantly, application of the pharmacophore predicted novel high affinity inhibitors of SARS-CoV-2 Mpro, that were validated by in vitro assays performed here and by a newly solved X-ray crystal structure. These results provide a strong basis for effective rational drug design campaigns against SARS-CoV-2 Mpro and a new computational approach to screen protein targets with malleable binding sites.", "doi": "10.1021/acsptsci.0c00215", "pmid": "34136757", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8009102"}], "notes": [], "created": "2021-06-28T18:41:25.728Z", "modified": "2021-07-06T09:01:14.453Z"}, {"entity": "publication", "iuid": "b6cac9c277864b59bfd7fa173087685b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b6cac9c277864b59bfd7fa173087685b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b6cac9c277864b59bfd7fa173087685b"}}, "title": "Self-Perceived Life Satisfaction during the First Wave of the COVID-19 Pandemic in Sweden: A Cross-Sectional Study.", "authors": [{"family": "Brog\u00e5rdh", "given": "Christina", "initials": "C", "orcid": "0000-0002-9249-9421", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12898e4072414c3ea7bd1fd6dc3be4d4.json"}}, {"family": "Hammarlund", "given": "Catharina Sj\u00f6dahl", "initials": "CS", "orcid": "0000-0001-6071-6922", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8a4960ca87043e3b465c63e9256c96f.json"}}, {"family": "Eek", "given": "Frida", "initials": "F"}, {"family": "Stigmar", "given": "Kjerstin", "initials": "K"}, {"family": "Lindgren", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-9910-0380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a15011595cd540e6aec99ce62a9b70a4.json"}}, {"family": "Schouenborg", "given": "Anna Trulsson", "initials": "AT"}, {"family": "Hansson", "given": "Eva Ekvall", "initials": "EE"}], "type": "journal article", "published": "2021-06-09", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "12", "pages": "6234"}, "abstract": "Currently, there is limited knowledge on how the Swedish strategy with more lenient public health restrictions during the COVID-19 pandemic has influenced people's life satisfaction. Here, we investigated self-reported life satisfaction during the first wave of the pandemic in Sweden, and perceived changes in life satisfaction in relation to various sociodemographic factors. A total of 1082 people (mean age 48 (SD 12.2); 82% women) responded to an online survey during autumn 2020 including the \"Life Satisfaction Questionnaire-11\". A majority (69%) were satisfied with life as a whole, and with other important life domains, with the exception of contact with friends and sexual life. An equal share reported that life as a whole had either deteriorated (28%) or improved (29%). Of those that perceived a deterioration, 95% considered it to be due to the pandemic. Regarding deteriorated satisfaction with life as a whole, higher odds were found in the following groups: having no children living at home; being middle aged; having other sources of income than being employed; and having a chronic disease. The Swedish strategy might have contributed to the high proportion of satisfied people. Those who perceived a deterioration in life satisfaction may, however, need attention from Swedish Welfare Authorities.", "doi": "10.3390/ijerph18126234", "pmid": "34207621", "labels": {"Category: Public Health": null, "Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8296066"}, {"db": "pii", "key": "ijerph18126234"}], "notes": [], "created": "2021-07-05T14:43:45.842Z", "modified": "2023-06-19T14:34:11.088Z"}, {"entity": "publication", "iuid": "5e62d79cca764b5b8326f8e1e1f71a28", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e62d79cca764b5b8326f8e1e1f71a28.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e62d79cca764b5b8326f8e1e1f71a28"}}, "title": "SARS-CoV-2 Variants of Interest and Concern naming scheme conducive for global discourse.", "authors": [{"family": "Konings", "given": "Frank", "initials": "F", "orcid": "0000-0003-0070-4457", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6676f07da06e4af68d3613f829990251.json"}}, {"family": "Perkins", "given": "Mark D", "initials": "MD"}, {"family": "Kuhn", "given": "Jens H", "initials": "JH"}, {"family": "Pallen", "given": "Mark J", "initials": "MJ", "orcid": "0000-0003-1807-3657", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/62d797d8942c4121a70b1bd77a0d4e9e.json"}}, {"family": "Alm", "given": "Erik J", "initials": "EJ"}, {"family": "Archer", "given": "Brett N", "initials": "BN"}, {"family": "Barakat", "given": "Amal", "initials": "A"}, {"family": "Bedford", "given": "Trevor", "initials": "T"}, {"family": "Bhiman", "given": "Jinal N", "initials": "JN"}, {"family": "Caly", "given": "Leon", "initials": "L"}, {"family": "Carter", "given": "Lisa L", "initials": "LL"}, {"family": "Cullinane", "given": "Anne", "initials": "A"}, {"family": "de Oliveira", "given": "Tulio", "initials": "T", "orcid": "0000-0002-3027-5254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3dadcb78141a496ba76769d69667bf79.json"}}, {"family": "Druce", "given": "Julian", "initials": "J"}, {"family": "El Masry", "given": "Ihab", "initials": "I"}, {"family": "Evans", "given": "Roger", "initials": "R"}, {"family": "Gao", "given": "George F", "initials": "GF"}, {"family": "Gorbalenya", "given": "Alexander E", "initials": "AE", "orcid": "0000-0002-4967-7341", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76287aa33e034511934c0d16214ecaec.json"}}, {"family": "Hamblion", "given": "Esther", "initials": "E"}, {"family": "Herring", "given": "Belinda L", "initials": "BL"}, {"family": "Hodcroft", "given": "Emma", "initials": "E"}, {"family": "Holmes", "given": "Edward C", "initials": "EC", "orcid": "0000-0001-9596-3552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d784e4faf11463993992797e354dfc9.json"}}, {"family": "Kakkar", "given": "Manish", "initials": "M"}, {"family": "Khare", "given": "Shagun", "initials": "S"}, {"family": "Koopmans", "given": "Marion P G", "initials": "MPG", "orcid": "0000-0002-5204-2312", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80d7f1e97b934289b7095013ef6e998d.json"}}, {"family": "Korber", "given": "Bette", "initials": "B"}, {"family": "Leite", "given": "Juliana", "initials": "J"}, {"family": "MacCannell", "given": "Duncan", "initials": "D"}, {"family": "Marklewitz", "given": "Marco", "initials": "M"}, {"family": "Maurer-Stroh", "given": "Sebastian", "initials": "S"}, {"family": "Rico", "given": "Jairo Andres Mendez", "initials": "JAM"}, {"family": "Munster", "given": "Vincent J", "initials": "VJ", "orcid": "0000-0002-2288-3196", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1f2569e7fe5442d968b3d89c88599d1.json"}}, {"family": "Neher", "given": "Richard", "initials": "R", "orcid": "0000-0003-2525-1407", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a31564f19214fbdb275578ed05a6bcb.json"}}, {"family": "Munnink", "given": "Bas Oude", "initials": "BO", "orcid": "0000-0002-9394-1189", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19923669d04a47ebb5c7c93d20ecedc3.json"}}, {"family": "Pavlin", "given": "Boris I", "initials": "BI"}, {"family": "Peiris", "given": "Malik", "initials": "M", "orcid": "0000-0001-8217-5995", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9395f3f6fc44427b0dbf04988bfde22.json"}}, {"family": "Poon", "given": "Leo", "initials": "L", "orcid": "0000-0002-9101-7953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6595eec1d268410fad9018a8c7dd20c6.json"}}, {"family": "Pybus", "given": "Oliver", "initials": "O", "orcid": "0000-0002-8797-2667", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3770f4e971b34afbb61f6276d43767a1.json"}}, {"family": "Rambaut", "given": "Andrew", "initials": "A", "orcid": "0000-0003-4337-3707", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d25e62e17c243f3ab72304ca504e296.json"}}, {"family": "Resende", "given": "Paola", "initials": "P", "orcid": "0000-0002-2884-3662", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b51db0165c14686b31f624bf075f18b.json"}}, {"family": "Subissi", "given": "Lorenzo", "initials": "L", "orcid": "0000-0001-5147-575X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/454c226e834a4829a330df1c4b604855.json"}}, {"family": "Thiel", "given": "Volker", "initials": "V", "orcid": "0000-0002-5783-0887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c6d7b184da743e5975d3009cad5a802.json"}}, {"family": "Tong", "given": "Suxiang", "initials": "S"}, {"family": "van der Werf", "given": "Sylvie", "initials": "S", "orcid": "0000-0002-1148-4456", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/610e999fc3fa4d24aceecf5a13122ecf.json"}}, {"family": "von Gottberg", "given": "Anne", "initials": "A"}, {"family": "Ziebuhr", "given": "John", "initials": "J", "orcid": "0000-0002-5741-8825", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4588eb2e70a4dafa2bdf92849f68837.json"}}, {"family": "Van Kerkhove", "given": "Maria D", "initials": "MD"}], "type": "journal article", "published": "2021-06-09", "journal": {"title": "Nat Microbiol", "issn": "2058-5276", "issn-l": null}, "abstract": null, "doi": "10.1038/s41564-021-00932-w", "pmid": "34108654", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41564-021-00932-w"}], "notes": [], "created": "2021-06-11T05:06:16.140Z", "modified": "2021-06-11T05:06:34.710Z"}, {"entity": "publication", "iuid": "e442369dddb84c968e6528b2c18d7536", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e442369dddb84c968e6528b2c18d7536.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e442369dddb84c968e6528b2c18d7536"}}, "title": "Reduction of pediatric emergency visits during the COVID-19 pandemic in a region with open preschools and schools.", "authors": [{"family": "Rhedin", "given": "Samuel Arthur", "initials": "SA"}, {"family": "Ryd Rinder", "given": "Malin", "initials": "M"}, {"family": "Hildenwall", "given": "Helena", "initials": "H"}, {"family": "Herlenius", "given": "Eric", "initials": "E"}, {"family": "Hertting", "given": "Olof", "initials": "O"}, {"family": "Luthander", "given": "Joachim", "initials": "J"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Nijman", "given": "Ruud", "initials": "R"}, {"family": "Olsson-\u00c5kefeldt", "given": "Selma", "initials": "S"}, {"family": "Alfven", "given": "Tobias", "initials": "T"}], "type": "journal article", "published": "2021-06-09", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": null, "issue": null, "pages": null}, "abstract": "Previous studies have reported a reduction in pediatric emergency visits for communicable diseases during the COVID-19 pandemic, which has been related to the use of face masks and school closures. As Sweden imposed less strict restrictions as compared to most countries we aimed to assess the effect of the behavioral changes, however without school closures and general usage of face masks in the society, on the spread of communicable diseases in children. We calculated cumulative incidences of pediatric emergency visits for lower respiratory tract infections (LRTIs), gastroenteritis and as a control diagnosis urinary tract infections (UTIs) comparing 2020 with 2018-2019. Our results suggests that the behavioral changes including improved basal hygiene routines and physical distancing, had a major impact on the disease transmission of LRTIs (cumulative incidence 0.24% in 2020 versus 0.57% during 2018-2019, p<0.001) and gastroenteritis (0.26% versus 0.87%, p<0.001) in children but observed a small increase in UTIs (0.22% versus 0.20%, p=0.01). This raises the question on to what extent some of these recommendations can and should be extended in the post pandemic era.", "doi": "10.1111/apa.15978", "pmid": "34107120", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-10T10:14:00.072Z", "modified": "2021-07-14T09:35:15.224Z"}, {"entity": "publication", "iuid": "415035fac5ab476b81c0a067ef352a19", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/415035fac5ab476b81c0a067ef352a19.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/415035fac5ab476b81c0a067ef352a19"}}, "title": "COVID-19 and Health Care Leaders: How Could Emotional Intelligence Be a Helpful Resource during a Pandemic?", "authors": [{"family": "Rossettini", "given": "Giacomo", "initials": "G"}, {"family": "Conti", "given": "Cristiana", "initials": "C"}, {"family": "Suardelli", "given": "Martina", "initials": "M"}, {"family": "Geri", "given": "Tommaso", "initials": "T"}, {"family": "Palese", "given": "Alvisa", "initials": "A"}, {"family": "Turolla", "given": "Andrea", "initials": "A"}, {"family": "Lovato", "given": "Andrea", "initials": "A"}, {"family": "Gianola", "given": "Silvia", "initials": "S"}, {"family": "Dell'Isola", "given": "Andrea", "initials": "A"}], "type": "journal article", "published": "2021-06-09", "journal": {"title": "Phys Ther", "issn": "1538-6724", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1093/ptj/pzab143", "pmid": "34101807", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6294530"}], "notes": [], "created": "2021-06-09T19:03:08.563Z", "modified": "2021-07-14T09:37:46.670Z"}, {"entity": "publication", "iuid": "61d6b962006344b99192d107bf56ae86", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61d6b962006344b99192d107bf56ae86.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61d6b962006344b99192d107bf56ae86"}}, "title": "Assessing the effects of calculated inaction on national responses to the COVID-19 crisis.", "authors": [{"family": "Zahariadis", "given": "Nikolaos", "initials": "N", "orcid": "0000-0003-2457-0561", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51bd7d14c9584d04a7eafba7f440c34c.json"}}, {"family": "Ceccoli", "given": "Stephen", "initials": "S", "orcid": "0000-0003-3789-061X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/036f98a2d87d464d98ddc7dc876467cd.json"}}, {"family": "Petridou", "given": "Evangelia", "initials": "E", "orcid": "0000-0001-7316-4899", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21de455914874bdf8fbaf544e51053b0.json"}}], "type": "journal article", "published": "2021-06-09", "journal": {"title": "Risk Hazards Crisis Public Policy", "issn": "1944-4079", "issn-l": null}, "abstract": "How does calculated inaction affect subsequent responses to the COVID-19 crisis? We argue that when governments employ calculated inaction during crises, they are more likely to manipulate the technical (scientific) aspects of national responses and highlight symbolic politics, each in the name of projecting power and strengthening the regime's governing authority. Using theoretical insight from McConnell and 't Hart's policy inaction typology, we investigate sense-making and crisis response narratives in China and Greece. We conclude with implications for policymaking and the crisis management literature.", "doi": "10.1002/rhc3.12230", "pmid": "34226845", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "RHC312230"}, {"db": "pmc", "key": "PMC8242484"}], "notes": [], "created": "2021-08-06T08:41:54.181Z", "modified": "2021-08-06T08:41:54.277Z"}, {"entity": "publication", "iuid": "7b0d6322d30546cba83126492632adeb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b0d6322d30546cba83126492632adeb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b0d6322d30546cba83126492632adeb"}}, "title": "Impact of COVID-19 pandemic on mental health and health behaviors in Swedish adolescents.", "authors": [{"family": "Chen", "given": "Yun", "initials": "Y"}, {"family": "Osika", "given": "Walter", "initials": "W"}, {"family": "Henriksson", "given": "G\u00f6ran", "initials": "G"}, {"family": "Dahlstrand", "given": "Johan", "initials": "J"}, {"family": "Friberg", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2021-06-08", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": null, "issue": null, "pages": "14034948211021724"}, "abstract": "There is an urgent need to explore the impact of the COVID-19 pandemic on adolescent mental health and health behaviours. To date, there are no such studies on Swedish adolescents. As COVID-19 emerged in the middle of our ongoing 2-year follow-up examination of the Study of Adolescence Resilience and Stress, we had the unique opportunity to use the corona outbreak as a 'natural experiment' to study the impact of COVID-19 on 15-year-old adolescents in Sweden.\r\n\r\nAdolescents (baseline age 13.6\u00b10.4 years) were recruited from schools in western Sweden (during the COVID-19 outbreak schools were kept open for those under 16 years of age). The COVID-19 pandemic reached Sweden on 31 January 2020. A total of 1316 adolescents answered the 2-year follow-up survey before (unexposed to COVID-19 pandemic, controls) and 584 after 1 February 2020 (COVID19-exposed). Data on stress, psychosomatic symptoms, happiness, relationships with parents and peers, school and health behaviours were collected.\r\n\r\nAdolescents reported higher levels of stress and psychosomatic symptoms and lower levels of happiness at follow-up compared to baseline. These changes occurred to a similar extent in both the control and COVID-19-exposed groups. Likewise, the COVID-19-exposed group showed no deterioration in peer relations or relations with parents versus controls. We did not find any significant differences between groups regarding sleep duration and physical activity. Conclusions: Swedish adolescents exposed to COVID-19 during most of 2020 showed no differences in longitudinal changes in mental health, relationships with parents and peers, and health behaviours compared to those not exposed to COVID-19.", "doi": "10.1177/14034948211021724", "pmid": "34100665", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Funder: H2020": null, "Funder: VR": null}, "xrefs": [], "notes": [], "created": "2021-06-09T19:04:07.985Z", "modified": "2021-07-14T09:24:47.762Z"}, {"entity": "publication", "iuid": "daeeea3c68554772b7f455f7328bfc44", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/daeeea3c68554772b7f455f7328bfc44.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/daeeea3c68554772b7f455f7328bfc44"}}, "title": "Dying from cancer with COVID-19: age, sex, socio-economic status, and comorbidities", "authors": [{"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "Hedman", "given": "Christel", "initials": "C"}, {"family": "Adlitzer", "given": "Helena", "initials": "H"}, {"family": "Schultz", "given": "Torbj\u00f6rn", "initials": "T"}], "type": "journal-article", "published": "2021-06-08", "journal": {"title": "Acta Oncologica", "issn": "0284-186X", "issn-l": null, "volume": null, "issue": null, "pages": "1-6"}, "abstract": "The COVID-19 pandemic has caused excess deaths (all causes) and has disproportionately affected the elderly with certain characteristics.\r\n\r\nTo study how COVID-19 affected cancer deaths regarding age, sex, socio-economic status, comorbidities, and access to palliative care. An additional objective was to study changes in place of care and death.\r\n\r\nA descriptive, retrospective study of all cancer patients who died during March-May 2020 in the Stockholm region, n = 1467 of which 278 died with a COVID-19 diagnosis, compared with deaths in 2016-2019. The Stockholm Regional Council's central data warehouse was used. T-tests, 95% CI, Wilcoxon and chi-squared tests were used for comparisons.\r\n\r\nThere were excess cancer deaths compared with 2016-2019 ( p < 0.001) and patients dying with a COVID-19 diagnosis were older (79.7 vs. 75.9 years, p < 0.0001), more often male (67% vs. 55%, p < 0.0001), and had more comorbidities (Charlson Comorbidity Index 1.6 vs. 1.1, p < 0.0001). Patients with COVID-19 more seldom had access to palliative care (34% vs. 59%, p = 0.008), had more changes in place of care during the last two weeks of life (p < 0.0001) and died more often in acute hospitals (34% vs. 14%, p < 0.0001). For the subgroup with access to palliative care, the hospital deaths for individuals with and without a COVID-19 diagnosis were 11% and 4%, respectively (p = 0.008).\r\n\r\nCancer patients dying with a COVID-19 diagnosis were older, more often male, and had more comorbidities. A COVID-19 diagnosis negatively affected the probability of being admitted to specialized palliative care and increased the likelihood of dying in an acute hospital.", "doi": "10.1080/0284186x.2021.1934536", "pmid": "34101521", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-09T19:03:41.769Z", "modified": "2021-07-14T09:23:35.833Z"}, {"entity": "publication", "iuid": "b3310f859ee940a4b51f6c4b608645f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b3310f859ee940a4b51f6c4b608645f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b3310f859ee940a4b51f6c4b608645f4"}}, "title": "Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2", "authors": [{"family": "O'Toole", "given": "A", "initials": "A"}, {"family": "Hill", "given": "V", "initials": "V"}], "type": "journal article", "published": "2021-06-07", "journal": {"title": "Wellcome Open Res", "issn": "2398-502X", "issn-l": null, "volume": "6", "issue": null, "pages": "121"}, "abstract": "Late in 2020, two genetically-distinct clusters of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with mutations of biological concern were reported, one in the United Kingdom and one in South Africa. Using a combination of data from routine surveillance, genomic sequencing and international travel we track the international dispersal of lineages B.1.1.7 and B.1.351 (variant 501Y-V2). We account for potential biases in genomic surveillance efforts by including passenger volumes from location of where the lineage was first reported, London and South Africa respectively. Using the software tool grinch (global report investigating novel coronavirus haplotypes), we track the international spread of lineages of concern with automated daily reports, Further, we have built a custom tracking website (cov-lineages.org/global_report.html) which hosts this daily report and will continue to include novel SARS-CoV-2 lineages of concern as they are detected.", "doi": "https://doi.org/10.12688/wellcomeopenres.16661.1", "pmid": "34095513", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pmc", "key": "PMC8176267"}, {"db": "URL", "key": "https://zenodo.org/record/4642401#.YZZRQS8w3OQ", "description": "Accession IDs included in publication Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2"}, {"db": "URL", "key": "https://zenodo.org/record/4704471#.YZZRyS8w3OQ", "description": "Supplementary materials with group affiliations for Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2"}, {"db": "URL", "key": "https://zenodo.org/record/4640140#.YZZRRy8w1TY", "description": "Data underlying the cov-lineages.org website"}], "notes": [], "created": "2021-06-07T15:39:21.116Z", "modified": "2021-11-18T13:17:11.237Z"}, {"entity": "publication", "iuid": "b67d71cac8ed4f03995e13a88ac7e12a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b67d71cac8ed4f03995e13a88ac7e12a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b67d71cac8ed4f03995e13a88ac7e12a"}}, "title": "Strategies to Improve Antimicrobial Utilization with a Special Focus on Developing Countries.", "authors": [{"family": "Godman", "given": "Brian", "initials": "B", "orcid": "0000-0001-6539-6972", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e76103610619453b84eab8de36f169cc.json"}}, {"family": "Egwuenu", "given": "Abiodun", "initials": "A", "orcid": "0000-0002-9369-4771", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70e982f868684b5780a54ecc8aa5a943.json"}}, {"family": "Haque", "given": "Mainul", "initials": "M", "orcid": "0000-0002-6124-7993", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b474f4ad9837460e84f88097a5cd639f.json"}}, {"family": "Malande", "given": "Oliver Ombeva", "initials": "OO"}, {"family": "Schellack", "given": "Natalie", "initials": "N"}, {"family": "Kumar", "given": "Santosh", "initials": "S", "orcid": "0000-0002-5117-7872", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3e56ccd71c894b54a1412fc4a53652c2.json"}}, {"family": "Saleem", "given": "Zikria", "initials": "Z", "orcid": "0000-0003-3202-6347", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/029d4b30cc724148a1225090d3f063ee.json"}}, {"family": "Sneddon", "given": "Jacqueline", "initials": "J"}, {"family": "Hoxha", "given": "Iris", "initials": "I"}, {"family": "Islam", "given": "Salequl", "initials": "S"}, {"family": "Mwita", "given": "Julius", "initials": "J"}, {"family": "do Nascimento", "given": "Renata Cristina Rezende Macedo", "initials": "RCRM", "orcid": "0000-0001-7756-2157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eec0a62241f4ea8931a95d92f34fa73.json"}}, {"family": "Dias God\u00f3i", "given": "Isabella Piassi", "initials": "IP", "orcid": "0000-0002-0568-6625", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6ade8b9c4e94a64add5b0d5b6911a27.json"}}, {"family": "Niba", "given": "Loveline Lum", "initials": "LL", "orcid": "0000-0002-5938-4913", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/321efd54c80f410a97a4887bcbb9e4d5.json"}}, {"family": "Amu", "given": "Adefolarin A", "initials": "AA"}, {"family": "Acolatse", "given": "Joseph", "initials": "J", "orcid": "0000-0001-6556-3208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6c03eeda55764c609acb5cb91dacbbd3.json"}}, {"family": "Incoom", "given": "Robert", "initials": "R"}, {"family": "Sefah", "given": "Israel Abebrese", "initials": "IA", "orcid": "0000-0001-6963-0519", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/073a513f62804d9fb48c4f846c747c54.json"}}, {"family": "Opanga", "given": "Sylvia", "initials": "S"}, {"family": "Kurdi", "given": "Amanj", "initials": "A", "orcid": "0000-0001-5036-1988", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be9bf17786754363929dc0faaae8c323.json"}}, {"family": "Chikowe", "given": "Ibrahim", "initials": "I", "orcid": "0000-0002-8231-9140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9eec6427097437eb172355a62854faf.json"}}, {"family": "Khuluza", "given": "Felix", "initials": "F"}, {"family": "Kibuule", "given": "Dan", "initials": "D", "orcid": "0000-0002-6908-2177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4344137451d04535a5875183b9abc24e.json"}}, {"family": "Ogunleye", "given": "Olayinka O", "initials": "OO"}, {"family": "Olalekan", "given": "Adesola", "initials": "A", "orcid": "0000-0002-8921-1909", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4780e3a28e2b44a0ac5c20cecc469852.json"}}, {"family": "Markovic-Pekovic", "given": "Vanda", "initials": "V"}, {"family": "Meyer", "given": "Johanna C", "initials": "JC"}, {"family": "Alfadl", "given": "Abubakr", "initials": "A"}, {"family": "Phuong", "given": "Thuy Nguyen Thi", "initials": "TNT"}, {"family": "Kalungia", "given": "Aubrey C", "initials": "AC"}, {"family": "Campbell", "given": "Stephen", "initials": "S"}, {"family": "Pisana", "given": "Alice", "initials": "A"}, {"family": "Wale", "given": "Janney", "initials": "J"}, {"family": "Seaton", "given": "R Andrew", "initials": "RA"}], "type": "journal article", "published": "2021-06-07", "journal": {"title": "Life (Basel)", "issn": "2075-1729", "issn-l": null, "volume": "11", "issue": "6", "pages": null}, "abstract": "Antimicrobial resistance (AMR) is a high priority across countries as it increases morbidity, mortality and costs. Concerns with AMR have resulted in multiple initiatives internationally, nationally and regionally to enhance appropriate antibiotic utilization across sectors to reduce AMR, with the overuse of antibiotics exacerbated by the COVID-19 pandemic. Effectively tackling AMR is crucial for all countries. Principally a narrative review of ongoing activities across sectors was undertaken to improve antimicrobial use and address issues with vaccines including COVID-19. Point prevalence surveys have been successful in hospitals to identify areas for quality improvement programs, principally centering on antimicrobial stewardship programs. These include reducing prolonged antibiotic use to prevent surgical site infections. Multiple activities centering on education have been successful in reducing inappropriate prescribing and dispensing of antimicrobials in ambulatory care for essentially viral infections such as acute respiratory infections. It is imperative to develop new quality indicators for ambulatory care given current concerns, and instigate programs with clear public health messaging to reduce misinformation, essential for pandemics. Regular access to effective treatments is needed to reduce resistance to treatments for HIV, malaria and tuberculosis. Key stakeholder groups can instigate multiple initiatives to reduce AMR. These need to be followed up.", "doi": "10.3390/life11060528", "pmid": "34200116", "labels": {"Type: Review": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8229985"}, {"db": "pii", "key": "life11060528"}], "notes": [], "created": "2021-07-05T14:33:03.361Z", "modified": "2023-06-19T07:30:35.555Z"}, {"entity": "publication", "iuid": "af7bab2d24e543b19d644dbd8546b0a7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/af7bab2d24e543b19d644dbd8546b0a7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/af7bab2d24e543b19d644dbd8546b0a7"}}, "title": "SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease?", "authors": [{"family": "Sancho-Shimizu", "given": "Vanessa", "initials": "V"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A"}, {"family": "Biggs", "given": "Catherine M", "initials": "CM"}, {"family": "Toubiana", "given": "Julie", "initials": "J"}, {"family": "Lucas", "given": "Carrie L", "initials": "CL"}, {"family": "Henrickson", "given": "Sarah E", "initials": "SE"}, {"family": "Belot", "given": "Alexandre", "initials": "A"}, {"family": "MIS-C@CHGE", "given": "", "initials": ""}, {"family": "Tangye", "given": "Stuart G", "initials": "SG"}, {"family": "Milner", "given": "Joshua D", "initials": "JD"}, {"family": "Levin", "given": "Michael", "initials": "M"}, {"family": "Abel", "given": "Laurent", "initials": "L"}, {"family": "Bogunovic", "given": "Dusan", "initials": "D"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}], "type": "journal article", "published": "2021-06-07", "journal": {"title": "J Exp Med", "issn": "1540-9538", "volume": "218", "issue": "6", "issn-l": null}, "abstract": "Multisystem inflammatory syndrome in children (MIS-C) emerged in April 2020 in communities with high COVID-19 rates. This new condition is heterogenous but resembles Kawasaki disease (KD), a well-known but poorly understood and clinically heterogenous pediatric inflammatory condition for which weak associations have been found with a myriad of viral illnesses. Epidemiological data clearly indicate that SARS-CoV-2 is the trigger for MIS-C, which typically occurs about 1 mo after infection. These findings support the hypothesis of viral triggers for the various forms of classic KD. We further suggest that rare inborn errors of immunity (IEIs) altering the immune response to SARS-CoV-2 may underlie the pathogenesis of MIS-C in some children. The discovery of monogenic IEIs underlying MIS-C would shed light on its pathogenesis, paving the way for a new genetic approach to classic KD, revisited as a heterogeneous collection of IEIs to viruses.", "doi": "10.1084/jem.20210446", "pmid": "33904890", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "212029"}], "notes": [], "created": "2021-04-29T10:16:49.682Z", "modified": "2021-04-29T10:16:49.704Z"}, {"entity": "publication", "iuid": "e780251b40974ddea6e2be08b3dc8076", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e780251b40974ddea6e2be08b3dc8076.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e780251b40974ddea6e2be08b3dc8076"}}, "title": "Missed nursing care during the COVID-19 pandemic: a comparative observational study.", "authors": [{"family": "von Vogelsang", "given": "Ann-Christin", "initials": "A"}, {"family": "G\u00f6ransson", "given": "Katarina E", "initials": "KE"}, {"family": "Falk", "given": "Ann-Charlotte", "initials": "A"}, {"family": "Nymark", "given": "Carolin", "initials": "C"}], "type": "journal article", "published": "2021-06-07", "journal": {"title": "J Nurs Manag", "issn": "1365-2834", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To evaluate frequencies, types of, and reasons for missed nursing care during the COVID-19 pandemic at inpatient wards in a highly specialized university hospital.\r\n\r\nRegistered nurse/patient ratio and nursing competence is known to affect patient outcomes. The first wave of the COVID-19 pandemic entailed novel ways for staffing to meet the expected increased acute care demand, which potentially could impact on quality of care.\r\n\r\nA comparative cross-sectional study was conducted, using the MISSCARE Survey. A sample of nursing staff during the first wave of the COVID-19 pandemic (n=130) was compared with a reference sample (n=157).\r\n\r\nFew differences between samples concerning elements of missed care, and no significant differences concerning reasons for missed care were found. Most participants perceived the quality of care and the patient safety to be good.\r\n\r\nThe results may be explained by three factors: maintained registered nurse/patient ratio, patients' dependency levels and that nursing managers could maintain the staffing needs with a sufficient skill mix.\r\n\r\nNursing managers impact on the occurrence of MNC; to provide a sufficient registered nurse/patient ratio and skill mix when staffing. They play an important role in anticipatory planning, and during infectious diseases outbreaks.", "doi": "10.1111/jonm.13392", "pmid": "34097799", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-08T09:02:41.566Z", "modified": "2021-07-14T09:21:04.995Z"}, {"entity": "publication", "iuid": "00ce2e2616f845da86a5b7e7c6321f81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/00ce2e2616f845da86a5b7e7c6321f81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/00ce2e2616f845da86a5b7e7c6321f81"}}, "title": "Long-term consequences in critically ill COVID-19 patients: a prospective cohort study.", "authors": [{"family": "Schandl", "given": "Anna", "initials": "A"}, {"family": "Hedman", "given": "Anders", "initials": "A"}, {"family": "Lyng\u00e5", "given": "Patrik", "initials": "P"}, {"family": "Fathi Tachinabad", "given": "Sozan", "initials": "S"}, {"family": "Svefors", "given": "Jessica", "initials": "J"}, {"family": "Ro\u00ebl", "given": "Mari", "initials": "M"}, {"family": "Geborek", "given": "Anne", "initials": "A"}, {"family": "Franko", "given": "Mikael Andersson", "initials": "MA"}, {"family": "S\u00f6derberg", "given": "M\u00e5rten", "initials": "M"}, {"family": "Darlington", "given": "Pernilla", "initials": "P"}], "type": "journal article", "published": "2021-06-07", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "volume": null, "issue": null, "issn-l": "0001-5172"}, "abstract": "COVID-19 can cause severe disease with need of treatment in the intensive care unit (ICU) for several weeks. Increased knowledge is needed about the long-term consequences.\n\nThis is a single-center prospective follow-up study of COVID-19 patients admitted to the ICU for respiratory organ support between March and July 2020. Patients with invasive ventilation were compared with those with high-flow nasal oxygen (HFNO) or non-invasive ventilation (NIV) regarding functional outcome and health-related qualify of life. The mean follow-up time was 5 months after ICU discharge and included clinical history, three well-validated questionnaires about health-related quality of life and psychological health, pulmonary function test, 6-minute walk test (6MWT) and work ability. Data were analyzed with multivariable general linear and logistic regression models with 95% confidence intervals.\n\nAmong 248 ICU patients, 200 patients survived. Of these, 113 patients came for follow-up. Seventy patients (62%) had received invasive ventilation. Most patients reported impaired health-related quality of life. Approximately one third suffered from posttraumatic stress, anxiety and depression. Twenty-six percent had reduced total lung capacity, 34% had reduced 6MWT and 50% worked fulltime. The outcomes were similar regardless of ventilatory support, but invasive ventilation was associated with more bodily pain (MSD -19, 95% CI: -32 to -5) and <80% total lung capacity (OR 4.1, 95% CI: 1.3-16.5).\n\nAmong survivors of Covid-19 who required respiratory organ support, outcomes 5 months after discharge from ICU were largely similar among those requiring invasive compared to non-invasive ventilation.", "doi": "10.1111/aas.13939", "pmid": "34097753", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-08T09:01:42.327Z", "modified": "2021-06-08T09:05:02.198Z"}, {"entity": "publication", "iuid": "c8464d3e58c54986b1b603fae7036672", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c8464d3e58c54986b1b603fae7036672.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c8464d3e58c54986b1b603fae7036672"}}, "title": "A Cross-Sectional Survey on Medication Management Practices for Noncommunicable Diseases in Europe During the Second Wave of the COVID-19 Pandemic", "authors": [{"family": "\u00c1gh", "given": "Tam\u00e1s", "initials": "T"}, {"family": "van Boven", "given": "Job FM", "initials": "JF"}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Menditto", "given": "Enrica", "initials": "E"}, {"family": "Pinnock", "given": "Hilary", "initials": "H"}, {"family": "Tsiligianni", "given": "Ioanna", "initials": "I"}, {"family": "Petrova", "given": "Guenka", "initials": "G"}, {"family": "Poto\u010dnjak", "given": "Ines", "initials": "I"}, {"family": "Kamberi", "given": "Fatjona", "initials": "F"}, {"family": "Kardas", "given": "Przemyslaw", "initials": "P"}, {"family": null, "given": "", "initials": ""}], "type": "journal-article", "published": "2021-06-07", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "12", "issn-l": "1663-9812"}, "abstract": null, "doi": "10.3389/fphar.2021.685696", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:16:17.183Z", "modified": "2021-06-28T18:16:17.194Z"}, {"entity": "publication", "iuid": "a39156b910c74d5eab4c6f6bb1e90627", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a39156b910c74d5eab4c6f6bb1e90627.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a39156b910c74d5eab4c6f6bb1e90627"}}, "title": "Open science saves lives: lessons from the COVID-19 pandemic.", "authors": [{"family": "Besan\u00e7on", "given": "Lonni", "initials": "L"}, {"family": "Peiffer-Smadja", "given": "Nathan", "initials": "N"}, {"family": "Segalas", "given": "Corentin", "initials": "C"}, {"family": "Jiang", "given": "Haiting", "initials": "H"}, {"family": "Masuzzo", "given": "Paola", "initials": "P"}, {"family": "Smout", "given": "Cooper", "initials": "C"}, {"family": "Billy", "given": "Eric", "initials": "E"}, {"family": "Deforet", "given": "Maxime", "initials": "M"}, {"family": "Leyrat", "given": "Cl\u00e9mence", "initials": "C"}], "type": "letter", "published": "2021-06-05", "journal": {"title": "BMC Med Res Methodol", "issn": "1471-2288", "issn-l": null, "volume": "21", "issue": "1", "pages": "117"}, "abstract": "In the last decade Open Science principles have been successfully advocated for and are being slowly adopted in different research communities. In response to the COVID-19 pandemic many publishers and researchers have sped up their adoption of Open Science practices, sometimes embracing them fully and sometimes partially or in a sub-optimal manner. In this article, we express concerns about the violation of some of the Open Science principles and its potential impact on the quality of research output. We provide evidence of the misuses of these principles at different stages of the scientific process. We call for a wider adoption of Open Science practices in the hope that this work will encourage a broader endorsement of Open Science principles and serve as a reminder that science should always be a rigorous process, reliable and transparent, especially in the context of a pandemic where research findings are being translated into practice even more rapidly. We provide all data and scripts at https://osf.io/renxy/ .", "doi": "10.1186/s12874-021-01304-y", "pmid": "34090351", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12874-021-01304-y"}], "notes": [], "created": "2021-06-07T14:16:08.799Z", "modified": "2021-06-08T08:47:19.991Z"}, {"entity": "publication", "iuid": "d347c79105404ea8a601a07b6e2c0236", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d347c79105404ea8a601a07b6e2c0236.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d347c79105404ea8a601a07b6e2c0236"}}, "title": "Vaccine allergy: evidence to consider for COVID-19 vaccines.", "authors": [{"family": "Nilsson", "given": "Lennart", "initials": "L"}, {"family": "Csuth", "given": "\u00c1gnes", "initials": "\u00c1"}, {"family": "Storsaeter", "given": "Jann", "initials": "J"}, {"family": "Garvey", "given": "Lene H", "initials": "LH"}, {"family": "Jenmalm", "given": "Maria C", "initials": "MC"}], "type": "journal article", "published": "2021-06-04", "journal": {"title": "Curr Opin Allergy Clin Immunol", "issn": "1473-6322", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Whereas the COVID-19 pandemic has changed our lives worldwide, we hope that vaccination can combat the disease. We propose how to evaluate suspected severe allergic reactions to the vaccines so that as many as possible may be safely vaccinated.\r\n\r\nRare cases of severe allergic reactions after COVID-19 vaccination have been observed, seemingly at a higher frequency than for other vaccines. Few excipients are likely to have caused these reactions. IgE-mediated reactions to polyethylene glycol (PEG) and its derivatives are the most suspected, albeit hitherto unproven, causes. We suggest to make a diagnosis based on skin tests with PEG and PEG derivatives and that these be considered in relation to the decisions required before the first and the second vaccine dose. A vaccine without these excipients is available, but published data about its side effects are limited.\r\n\r\nThe underlying immunological mechanisms of the rare severe allergic reactions to the COVID-19 vaccines are poorly understood and need to be clarified. Identifying those who have an undiagnosed allergy to PEG and PEG derivatives is crucial before vaccination, and these substances are found in laxatives, cosmetics and in 30% of all our medications today.", "doi": "10.1097/ACI.0000000000000762", "pmid": "34091550", "labels": {"Type: Journal article": null, "Category: Health": null, "Research Area: Vaccine": null, "Category: Vaccines": null}, "xrefs": [{"db": "pii", "key": "00130832-900000000-98999"}], "notes": [], "created": "2021-06-07T14:06:39.950Z", "modified": "2021-12-06T12:28:38.925Z"}, {"entity": "publication", "iuid": "6c24155fe1c44fd0922da41e251baba7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c24155fe1c44fd0922da41e251baba7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c24155fe1c44fd0922da41e251baba7"}}, "title": "Schools do not need to close to reduce COVID\u201019 but other measures are advisable", "authors": [{"family": "Axelsson", "given": "Inge", "initials": "I"}], "type": "journal-article", "published": "2021-06-04", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1111/apa.15951", "pmid": null, "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-06-07T05:46:39.495Z", "modified": "2021-06-07T05:46:39.501Z"}, {"entity": "publication", "iuid": "a6ea0fe07eec4c6d918ce3abedc7e950", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6ea0fe07eec4c6d918ce3abedc7e950.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6ea0fe07eec4c6d918ce3abedc7e950"}}, "title": "Rapid and Sensitive Detection of SARS-CoV-2 Infection Using Quantitative Peptide Enrichment LC-MS/MS Analysis", "authors": [{"family": "Hober", "given": "Andreas", "initials": "A"}, {"family": "Hua", "given": "Tran Minh Khue", "initials": "TMK"}, {"family": "Foley", "given": "Dominic", "initials": "D"}, {"family": "McDonald", "given": "Thomas", "initials": "T"}, {"family": "Vissers", "given": "Johannes P C", "initials": "JPC"}, {"family": "Pattison", "given": "Rebecca", "initials": "R"}, {"family": "Ferries", "given": "Samantha", "initials": "S"}, {"family": "Hermansson", "given": "Sigurd", "initials": "S"}, {"family": "Betner", "given": "Ingvar", "initials": "I"}, {"family": "Uhlen", "given": "Mathias", "initials": "M"}, {"family": "Razavi", "given": "Morteza", "initials": "M"}, {"family": "Yip", "given": "Richard", "initials": "R"}, {"family": "Pope", "given": "Matthew E", "initials": "ME"}, {"family": "Pearson", "given": "Terry W", "initials": "TW"}, {"family": "Anderson", "given": "N Leigh", "initials": "NL"}, {"family": "Bartlett", "given": "Amy", "initials": "A"}, {"family": "Calton", "given": "Lisa", "initials": "L"}, {"family": "Alm", "given": "Jessica J", "initials": "JJ"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Edfors", "given": "Fredrik", "initials": "F"}], "type": "posted-content", "published": "2021-06-04", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.06.02.21258097", "pmid": null, "labels": {"Type: Preprint": null, "Category: Imaging": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-06-09T10:38:27.339Z", "modified": "2021-06-18T09:12:42.452Z"}, {"entity": "publication", "iuid": "dc71c9532399475e89ef881d1800a4ec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dc71c9532399475e89ef881d1800a4ec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dc71c9532399475e89ef881d1800a4ec"}}, "title": "Plasma ACE2 predicts outcome of COVID-19 in hospitalized patients.", "authors": [{"family": "Kragstrup", "given": "Tue W", "initials": "TW"}, {"family": "Singh", "given": "Helene S\u00f8gaard", "initials": "HS"}, {"family": "Grundberg", "given": "Ida", "initials": "I"}, {"family": "Nielsen", "given": "Ane Langkilde-Lauesen", "initials": "AL"}, {"family": "Rivellese", "given": "Felice", "initials": "F"}, {"family": "Mehta", "given": "Arnav", "initials": "A"}, {"family": "Goldberg", "given": "Marcia B", "initials": "MB"}, {"family": "Filbin", "given": "Michael R", "initials": "MR"}, {"family": "Qvist", "given": "Per", "initials": "P"}, {"family": "Bibby", "given": "Bo Martin", "initials": "BM"}], "type": "journal article", "published": "2021-06-04", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "6", "pages": "e0252799"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin converting enzyme 2 (ACE2) enabling entrance of the virus into cells and causing the infection termed coronavirus disease of 2019 (COVID-19). Here, we investigate associations between plasma ACE2 and outcome of COVID-19.\r\n\r\nThis analysis used data from a large longitudinal study of 306 COVID-19 positive patients and 78 COVID-19 negative patients (MGH Emergency Department COVID-19 Cohort). Comprehensive clinical data were collected on this cohort, including 28-day outcomes. The samples were run on the Olink\u00ae Explore 1536 platform which includes measurement of the ACE2 protein. High admission plasma ACE2 in COVID-19 patients was associated with increased maximal illness severity within 28 days with OR = 1.8, 95%-CI: 1.4-2.3 (P < 0.0001). Plasma ACE2 was significantly higher in COVID-19 patients with hypertension compared with patients without hypertension (P = 0.0045). Circulating ACE2 was also significantly higher in COVID-19 patients with pre-existing heart conditions and kidney disease compared with patients without these pre-existing conditions (P = 0.0363 and P = 0.0303, respectively).\r\n\r\nThis study suggests that measuring plasma ACE2 is potentially valuable in predicting COVID-19 outcomes. Further, ACE2 could be a link between COVID-19 illness severity and its established risk factors hypertension, pre-existing heart disease and pre-existing kidney disease.", "doi": "10.1371/journal.pone.0252799", "pmid": "34086837", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-06434"}], "notes": [], "created": "2021-06-08T08:37:57.861Z", "modified": "2021-06-08T08:38:14.665Z"}, {"entity": "publication", "iuid": "d4851cb729ba4249b06c14b4894c8394", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4851cb729ba4249b06c14b4894c8394.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4851cb729ba4249b06c14b4894c8394"}}, "title": "Characterization of dysphagia and laryngeal findings in COVID-19 patients treated in the ICU-An observational clinical study.", "authors": [{"family": "Osbeck Sandblom", "given": "Hanna", "initials": "H"}, {"family": "Dotevall", "given": "Hans", "initials": "H"}, {"family": "Svennerholm", "given": "Kristina", "initials": "K"}, {"family": "Tuomi", "given": "Lisa", "initials": "L"}, {"family": "Finizia", "given": "Caterina", "initials": "C"}], "type": "journal article", "published": "2021-06-04", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "6", "pages": "e0252347"}, "abstract": "Dysphagia appears to be common in patients with severe COVID-19. Information about the characteristics of dysphagia and laryngeal findings in COVID-19 patients treated in the intensive care unit (ICU) is still limited.\r\n\r\nThe aim of this study was to evaluate oropharyngeal swallowing function and laryngeal appearance and function in patients with severe COVID-19.\r\n\r\nA series of 25 ICU patients with COVID-19 and signs of dysphagia were examined with fiberendoscopic evaluation of swallowing (FEES) during the latter stage of ICU care or after discharge from the ICU. Swallowing function and laryngeal findings were assessed with standard rating scales from video recordings.\r\n\r\nPooling of secretions was found in 92% of patients. Eleven patients (44%) showed signs of silent aspiration to the trachea on at least one occasion. All patients showed residue after swallowing to some degree both in the vallecula and hypopharynx. Seventy-six percent of patients had impaired vocal cord movement. Erythema of the vocal folds was found in 60% of patients and edema in the arytenoid region in 60%.\r\n\r\nImpairment of oropharyngeal swallowing function and abnormal laryngeal findings were common in this series of patients with severe COVID-19 treated in the ICU. To avoid complications related to dysphagia in this patient group, it seems to be of great importance to evaluate the swallowing function as a standard procedure, preferably at an early stage, before initiation of oral intake. Fiberendoscopic evaluation of swallowing is preferred due to the high incidence of pooling of secretion in the hypopharynx, silent aspiration, and residuals. Further studies of the impact on swallowing function in short- and long-term in patients with COVID-19 are warranted.", "doi": "10.1371/journal.pone.0252347", "pmid": "34086717", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-05126"}], "notes": [], "created": "2021-06-08T08:38:49.661Z", "modified": "2021-06-08T08:39:11.061Z"}, {"entity": "publication", "iuid": "a7a8f3f6520a4ac7979f9f30261eb800", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7a8f3f6520a4ac7979f9f30261eb800.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7a8f3f6520a4ac7979f9f30261eb800"}}, "title": "Changes in daily life and wellbeing in adults, 70 years and older, in the beginning of the COVID-19 pandemic", "authors": [{"family": "Fristedt", "given": "Sofi", "initials": "S"}, {"family": "Carlsson", "given": "Gunilla", "initials": "G"}, {"family": "Kyl\u00e9n", "given": "Maya", "initials": "M"}, {"family": "Jonsson", "given": "Oskar", "initials": "O"}, {"family": "Granbom", "given": "Marianne", "initials": "M"}], "type": "journal-article", "published": "2021-06-04", "journal": {"title": "Scandinavian Journal of Occupational Therapy", "issn": "1103-8128", "issn-l": null, "volume": null, "issue": null, "pages": "1-11"}, "abstract": null, "doi": "10.1080/11038128.2021.1933171", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-08T08:42:45.724Z", "modified": "2021-07-14T09:19:04.290Z"}, {"entity": "publication", "iuid": "91ebcee90c8b4fefa612a55ae006431e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/91ebcee90c8b4fefa612a55ae006431e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/91ebcee90c8b4fefa612a55ae006431e"}}, "title": "Sweden's coronavirus strategy: The Public Health Agency and the sites of controversy.", "authors": [{"family": "Pashakhanlou", "given": "Arash Heydarian", "initials": "AH", "orcid": "0000-0002-5451-298X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d282433a84da4177a3b91e6529f929c8.json"}}], "type": "journal article", "published": "2021-06-03", "journal": {"title": "World Med Health Policy", "issn": "2153-2028", "issn-l": null}, "abstract": "In contrast to the vast majority of Western countries, Sweden left large segments of the society open instead of imposing a lockdown to combat the spread of the coronavirus. As a result, the Swedish COVID-19 measures, largely devised by its expert agency on health, garnered widespread international attention. Despite the global interest in the corona strategy of the Public Health Agency of Sweden (PHAS), there are currently no systematic studies on their COVID-19 policy. The present investigation focuses on the controversies that have characterized PHAS' work with reference to risk assessments, facemasks, voluntarism, testing, and the protection of the elderly during the pandemic. Overall, this inquiry demonstrates that PHAS' risk assessments were initially overly optimistic and their facemask recommendations in conflict with large segments of the scientific community for an extensive period. Yet, their voluntary measures worked moderately well. In their testing, PHAS did not manage to deliver on their promises in time, whereas several measures implemented to protect the elderly were deemed inadequate and late.", "doi": "10.1002/wmh3.449", "pmid": "34226854", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "WMH3449"}, {"db": "pmc", "key": "PMC8242624"}], "notes": [], "created": "2021-08-06T08:41:14.004Z", "modified": "2021-08-06T08:41:14.062Z"}, {"entity": "publication", "iuid": "76bb2203fc7645e5aeeef5beca15a690", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76bb2203fc7645e5aeeef5beca15a690.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76bb2203fc7645e5aeeef5beca15a690"}}, "title": "Abrupt termination of the 2019/20 influenza season following preventive measures against COVID-19 in Denmark, Norway and Sweden", "authors": [{"family": "Emborg", "given": "Hanne Dorthe", "initials": "HD"}, {"family": "Carnahan", "given": "AnnaSara", "initials": "A"}, {"family": "Bragstad", "given": "Karoline", "initials": "K"}, {"family": "Trebbien", "given": "Ramona", "initials": "R"}, {"family": "Brytting", "given": "Mia", "initials": "M"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "Bystr\u00f6m", "given": "Emma", "initials": "E"}, {"family": "Vestergaard", "given": "Lasse S", "initials": "LS"}], "type": "journal-article", "published": "2021-06-03", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "22", "pages": null}, "abstract": null, "doi": "10.2807/1560-7917.es.2021.26.22.2001160", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-07T05:45:38.163Z", "modified": "2021-07-14T09:16:46.478Z"}, {"entity": "publication", "iuid": "60d0fffeda024af68146b7ddfb088951", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60d0fffeda024af68146b7ddfb088951.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60d0fffeda024af68146b7ddfb088951"}}, "title": "Symptoms of Depression and Anxiety During the Early Phase of the COVID-19 Pandemic in Sweden.", "authors": [{"family": "Rondung", "given": "Elisabet", "initials": "E"}, {"family": "Leiler", "given": "Anna", "initials": "A"}, {"family": "Meurling", "given": "Jennifer", "initials": "J"}, {"family": "Bj\u00e4rt\u00e5", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-06-02", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "pages": "562437", "issn-l": "2296-2565"}, "abstract": "In this cross-sectional study we aimed to assess symptoms of depression and anxiety at an early stage of the COVID-19 pandemic, and to explore factors predictive of these mental health outcomes. A sample of 1,503 participants, recruited from the general Swedish population, completed an online survey distributed through social media. In this sample, 22.2% reported clinically significant levels of depressive symptoms (PHQ-9 \u2265 10) and 10.9% indicated possible major depression using the PHQ-9 algorithm. Moreover, 28.3% reported clinically significant levels of anxiety (GAD-7 \u2265 8) and 9.7% severe anxiety and possible GAD (GAD-7 \u2265 15). Multiple linear regression analyses identified some common predictors for both outcomes. Age, having a stable income, and sufficient social stimulation, sleep, and recovery showed negative associations, whereas worry about the economy and overall burden showed positive associations. These results suggest an impact on mental health already at an early stage of the COVID-19 pandemic.", "doi": "10.3389/fpubh.2021.562437", "pmid": "34150691", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8206505"}], "notes": [], "created": "2021-06-28T18:23:49.877Z", "modified": "2023-01-13T14:44:35.901Z"}, {"entity": "publication", "iuid": "c3b94717e04649e1b6097a9f0472e679", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3b94717e04649e1b6097a9f0472e679.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3b94717e04649e1b6097a9f0472e679"}}, "title": "SARS-CoV-2 in hospital indoor environments is predominantly non-infectious.", "authors": [{"family": "Krambrich", "given": "Janina", "initials": "J"}, {"family": "Akaberi", "given": "Dario", "initials": "D"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Svensson", "given": "Lennart", "initials": "L"}, {"family": "Hagbom", "given": "Marie", "initials": "M"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "journal article", "published": "2021-06-02", "journal": {"title": "Virol J", "issn": "1743-422X", "issn-l": null, "volume": "18", "issue": "1", "pages": "109"}, "abstract": "The ongoing SARS-CoV-2 pandemic has spread rapidly worldwide and disease prevention is more important than ever. In the absence of a vaccine, knowledge of the transmission routes and risk areas of infection remain the most important existing tools to prevent further spread.\r\n\r\nHere we investigated the presence of the SARS-CoV-2 virus in the hospital environment at the Uppsala University Hospital Infectious Disease ward by RT-qPCR and determined the infectivity of the detected virus in vitro on Vero E6 cells.\r\n\r\nSARS-CoV-2 RNA was detected in several areas, although attempts to infect Vero E6 cells with positive samples were unsuccessful. However, RNase A treatment of positive samples prior to RNA extraction did not degrade viral RNA, indicating the presence of SARS-CoV-2 nucleocapsids or complete virus particles protecting the RNA as opposed to free viral RNA.\r\n\r\nOur results show that even in places where a moderate concentration (Ct values between 30 and 38) of SARS-CoV-2 RNA was found; no infectious virus could be detected. This suggests that the SARS-CoV-2 virus in the hospital environment subsides in two states; as infectious and as non-infectious. Future work should investigate the reasons for the non-infectivity of SARS-CoV-2 virions.", "doi": "10.1186/s12985-021-01556-6", "pmid": "34078386", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Category: Health": null, "Research Area: High-throughput and high-content serology": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12985-021-01556-6"}, {"db": "URL", "key": "https://static-content.springer.com/esm/art%3A10.1186%2Fs12985-021-01556-6/MediaObjects/12985_2021_1556_MOESM1_ESM.pdf", "description": "Ct values for all collected samples at the Uppsala University infectious disease ward"}], "notes": [], "created": "2021-06-04T11:04:45.124Z", "modified": "2021-08-25T08:17:42.781Z"}, {"entity": "publication", "iuid": "46e6889db97c4af2be73b1e55efe3b6d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46e6889db97c4af2be73b1e55efe3b6d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46e6889db97c4af2be73b1e55efe3b6d"}}, "title": "Point of care ultrasound screening for deep vein thrombosis in critically ill COVID-19 patients, an observational study.", "authors": [{"family": "Galien", "given": "Sarah", "initials": "S"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Stattin", "given": "Karl", "initials": "K"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Ros\u00e9n", "given": "Jacob", "initials": "J"}, {"family": "Uppsala Intensive Care COVID-19 Research Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-06-02", "journal": {"title": "Thromb J", "issn": "1477-9560", "issn-l": null, "volume": "19", "issue": "1", "pages": "38"}, "abstract": "Deep vein thrombosis (DVT) is common in critically ill patients with Coronavirus disease 2019 (COVID-19) and may cause fatal pulmonary embolism (PE) prior to diagnosis due to subtle clinical symptoms. The aim of this study was to explore the feasibility of bedside screening for DVT in critically ill COVID-19 patients performed by physicians with limited experience of venous ultrasound. We further aimed to compare inflammation, coagulation and organ dysfunction in patients with and without venous thromboembolism (VTE).\r\n\r\nThis observational study included patients with COVID-19 admitted to the intensive care unit (ICU) of a tertiary hospital in Sweden and screened for DVT with proximal compression ultrasound of the lower extremities between April and July 2020. Screening was performed by ICU residents having received a short online education and one hands-on-session. Pathological screening ultrasound was confirmed by formal ultrasound whereas patients with negative screening underwent formal ultrasound on clinical suspicion. Clinical data, laboratory findings and follow-up were extracted from medical records.\r\n\r\nOf 90 eligible patients, 56 were screened by seven ICU residents with no (n = 5) or limited (n = 2) previous experience of DVT ultrasound who performed a median of 4 (IQR 2-19) examinations. Four (7.1%) patients had pathological screening ultrasound of which three (5.6%) were confirmed by formal ultrasound. None of the 52 patients with negative screening ultrasound were diagnosed with DVT during follow-up. Six patients were diagnosed with PE of which four prior to negative screening and two following negative and positive screening respectively. Patients with VTE (n = 8) had higher median peak D-dimer (24.0 (IQR 14.2-50.5) vs. 2.8 (IQR 1.7-7.2) mg/L, p = 0.004), mean peak C-reactive protein (363 (SD 80) vs. 285 (SD 108) mg/L, p = 0.033) and median peak plasma creatinine (288 (IQR 131-328) vs. 94 (IQR 78-131) \u03bcmol/L, p = 0.009) compared to patients without VTE (n = 48). Five patients (63%) with VTE received continuous renal replacement therapy compared to six patients (13%) without VTE (p = 0.005).\r\n\r\nICU residents with no or limited experience could detect DVT with ultrasound in critically ill COVID-19 patients following a short education. VTE was associated with kidney dysfunction and features of hyperinflammation and hypercoagulation.\r\n\r\nClinicalTrials ID: NCT04316884 . Registered 20 March 2020.", "doi": "10.1186/s12959-021-00272-z", "pmid": "34078399", "labels": {"Type: Journal article": null, "Category: Health": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12959-021-00272-z"}, {"db": "ClinicalTrials.gov", "key": "NCT04316884"}, {"db": "URL", "key": "https://doi.org/10.17044/scilifelab.14229410.v1", "description": "Metadata record"}], "notes": [], "created": "2021-06-04T10:55:06.564Z", "modified": "2021-06-21T14:44:24.986Z"}, {"entity": "publication", "iuid": "c8641609df574656ac6e2104bcdc7fe6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c8641609df574656ac6e2104bcdc7fe6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c8641609df574656ac6e2104bcdc7fe6"}}, "title": "COVID-19 and stem cell transplantation; results from an EBMT and GETH multicenter prospective survey.", "authors": [{"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "de la Camara", "given": "Rafael", "initials": "R"}, {"family": "Mikulska", "given": "Malgorzata", "initials": "M"}, {"family": "Tridello", "given": "Gloria", "initials": "G"}, {"family": "Aguado", "given": "Beatriz", "initials": "B"}, {"family": "Zahrani", "given": "Mohsen Al", "initials": "MA"}, {"family": "Apperley", "given": "Jane", "initials": "J"}, {"family": "Berceanu", "given": "Ana", "initials": "A"}, {"family": "Bofarull", "given": "Rodrigo Martino", "initials": "RM"}, {"family": "Calbacho", "given": "Maria", "initials": "M"}, {"family": "Ciceri", "given": "Fabio", "initials": "F"}, {"family": "Lopez-Corral", "given": "Lucia", "initials": "L"}, {"family": "Crippa", "given": "Claudia", "initials": "C"}, {"family": "Fox", "given": "Maria Laura", "initials": "ML"}, {"family": "Grassi", "given": "Anna", "initials": "A"}, {"family": "Jimenez", "given": "Maria-Jose", "initials": "MJ"}, {"family": "Demir", "given": "Safiye Ko\u00e7ulu", "initials": "SK"}, {"family": "Kwon", "given": "Mi", "initials": "M"}, {"family": "Llamas", "given": "Carlos Vallejo", "initials": "CV"}, {"family": "Lorenzo", "given": "Jos\u00e9 Luis L\u00f3pez", "initials": "JLL"}, {"family": "Mielke", "given": "Stephan", "initials": "S"}, {"family": "Orchard", "given": "Kim", "initials": "K"}, {"family": "Porras", "given": "Rocio Parody", "initials": "RP"}, {"family": "Vallisa", "given": "Daniele", "initials": "D"}, {"family": "Xhaard", "given": "Alienor", "initials": "A"}, {"family": "Knelange", "given": "Nina Simone", "initials": "NS"}, {"family": "Cedillo", "given": "Angel", "initials": "A"}, {"family": "Kr\u00f6ger", "given": "Nicolaus", "initials": "N"}, {"family": "Pi\u00f1ana", "given": "Jos\u00e9 Luis", "initials": "JL"}, {"family": "Styczynski", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2021-06-02", "journal": {"title": "Leukemia", "issn": "1476-5551", "volume": null, "issue": null, "issn-l": null}, "abstract": "This study reports on 382 COVID-19 patients having undergone allogeneic (n = 236) or autologous (n = 146) hematopoietic cell transplantation (HCT) reported to the European Society for Blood and Marrow Transplantation (EBMT) or to the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH). The median age was 54.1 years (1.0-80.3) for allogeneic, and 60.6 years (7.7-81.6) for autologous HCT patients. The median time from HCT to COVID-19 was 15.8 months (0.2-292.7) in allogeneic and 24.6 months (-0.9 to 350.3) in autologous recipients. 83.5% developed lower respiratory tract disease and 22.5% were admitted to an ICU. Overall survival at 6 weeks from diagnosis was 77.9% and 72.1% in allogeneic and autologous recipients, respectively. Children had a survival of 93.4%. In multivariate analysis, older age (p = 0.02), need for ICU (p < 0.0001) and moderate/high immunodeficiency index (p = 0.04) increased the risk while better performance status (p = 0.001) decreased the risk for mortality. Other factors such as underlying diagnosis, time from HCT, GVHD, or ongoing immunosuppression did not significantly impact overall survival. We conclude that HCT patients are at high risk of developing LRTD, require admission to ICU, and have increased mortality in COVID-19.", "doi": "10.1038/s41375-021-01302-5", "pmid": "34079042", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41375-021-01302-5"}], "notes": [], "created": "2021-06-04T08:14:17.305Z", "modified": "2021-06-04T10:54:25.197Z"}, {"entity": "publication", "iuid": "a2c82a2f8756499cb454bd4e2cd18144", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2c82a2f8756499cb454bd4e2cd18144.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2c82a2f8756499cb454bd4e2cd18144"}}, "title": "A global analysis of the impact of COVID-19 stay-at-home restrictions on crime.", "authors": [{"family": "Nivette", "given": "Amy E", "initials": "AE"}, {"family": "Zahnow", "given": "Renee", "initials": "R"}, {"family": "Aguilar", "given": "Raul", "initials": "R"}, {"family": "Ahven", "given": "Andri", "initials": "A"}, {"family": "Amram", "given": "Shai", "initials": "S"}, {"family": "Ariel", "given": "Barak", "initials": "B"}, {"family": "Burbano", "given": "Mar\u00eda Jos\u00e9 Arosemena", "initials": "MJA"}, {"family": "Astolfi", "given": "Roberta", "initials": "R"}, {"family": "Baier", "given": "Dirk", "initials": "D"}, {"family": "Bark", "given": "Hyung-Min", "initials": "H"}, {"family": "Beijers", "given": "Joris E H", "initials": "JEH"}, {"family": "Bergman", "given": "Marcelo", "initials": "M"}, {"family": "Breetzke", "given": "Gregory", "initials": "G"}, {"family": "Concha-Eastman", "given": "I Alberto", "initials": "IA"}, {"family": "Curtis-Ham", "given": "Sophie", "initials": "S"}, {"family": "Davenport", "given": "Ryan", "initials": "R"}, {"family": "D\u00edaz", "given": "Carlos", "initials": "C"}, {"family": "Fleitas", "given": "Diego", "initials": "D"}, {"family": "Gerell", "given": "Manne", "initials": "M"}, {"family": "Jang", "given": "Kwang-Ho", "initials": "K"}, {"family": "K\u00e4\u00e4ri\u00e4inen", "given": "Juha", "initials": "J"}, {"family": "Lappi-Sepp\u00e4l\u00e4", "given": "Tapio", "initials": "T"}, {"family": "Lim", "given": "Woon-Sik", "initials": "W"}, {"family": "Revilla", "given": "Rosa Loureiro", "initials": "RL"}, {"family": "Mazerolle", "given": "Lorraine", "initials": "L"}, {"family": "Me\u0161ko", "given": "Gorazd", "initials": "G"}, {"family": "Pereda", "given": "Noem\u00ed", "initials": "N"}, {"family": "Peres", "given": "Maria F T", "initials": "MFT"}, {"family": "Poblete-Cazenave", "given": "Rub\u00e9n", "initials": "R"}, {"family": "Rose", "given": "Simon", "initials": "S"}, {"family": "Svensson", "given": "Robert", "initials": "R"}, {"family": "Trajtenberg", "given": "Nico", "initials": "N"}, {"family": "van der Lippe", "given": "Tanja", "initials": "T"}, {"family": "Veldkamp", "given": "Joran", "initials": "J"}, {"family": "Perdomo", "given": "Carlos J Vilalta", "initials": "CJV"}, {"family": "Eisner", "given": "Manuel P", "initials": "MP"}], "type": "journal article", "published": "2021-06-02", "journal": {"title": "Nat Hum Behav", "issn": "2397-3374", "issn-l": "2397-3374", "volume": null, "issue": null, "pages": null}, "abstract": "The stay-at-home restrictions to control the spread of COVID-19 led to unparalleled sudden change in daily life, but it is unclear how they affected urban crime globally. We collected data on daily counts of crime in 27 cities across 23 countries in the Americas, Europe, the Middle East and Asia. We conducted interrupted time series analyses to assess the impact of stay-at-home restrictions on different types of crime in each city. Our findings show that the stay-at-home policies were associated with a considerable drop in urban crime, but with substantial variation across cities and types of crime. Meta-regression results showed that more stringent restrictions over movement in public space were predictive of larger declines in crime.", "doi": "10.1038/s41562-021-01139-z", "pmid": "34079096", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41562-021-01139-z"}], "notes": [], "created": "2021-06-04T11:41:59.417Z", "modified": "2022-11-23T08:59:40.855Z"}, {"entity": "publication", "iuid": "59678e2f49ae4b0eaf262ea1fb91a031", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/59678e2f49ae4b0eaf262ea1fb91a031.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/59678e2f49ae4b0eaf262ea1fb91a031"}}, "title": "Electrolyte and acid-base imbalance in severe COVID-19.", "authors": [{"family": "Sj\u00f6str\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Rysz", "given": "Susanne", "initials": "S"}, {"family": "Sj\u00f6str\u00f6m", "given": "Henrik", "initials": "H"}, {"family": "H\u00f6ybye", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2021-06-01", "journal": {"title": "Endocr Connect", "issn": "2049-3614", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Acute systemic diseases, such as severe infections, can lead to electrolyte and acid-base alterations. To study the presence of electrolyte imbalance in severe COVID-19, we investigated the frequency and consequences of changes in electrolyte and acid-base patterns over time. We performed a retrospective cohort study including 406 patients with severe COVID-19. Levels of electrolytes, base excess, pH, serum osmolality and hematocrit, the first two weeks of hospitalization, were collected daily from the laboratory database and clinical data from patients' medical records. We found that hyponatremia was present in 57% of the patients at admission and hypernatremia in 2%. However, within two weeks of hospitalization 42% of the patients developed hypernatremia, more frequently in critically ill patients. Lower levels of sodium and potassium at admission was associated with need of mechanical ventilation. Decreased pH at admission was associated with both death and need of mechanical ventilation. Hypernatremia in the ICU was combined with rising base excess and a higher pH. In the group without intensive care, potassium levels was significantly lower in the patients with severe hypernatremia. Presence of hypernatremia during the first two weeks of hospitalization was associated with 3.942 (95% CI 2.269-6.851) times higher odds of death. In summary, hypernatremia was common and associated with longer hospital stay and a higher risk of death, suggesting that the dynamics of sodium is an important indicator of severity in COVID-19.", "doi": "10.1530/EC-21-0265", "pmid": "34156969", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "EC-21-0265"}], "notes": [], "created": "2021-06-28T18:22:10.843Z", "modified": "2021-06-28T18:22:24.253Z"}, {"entity": "publication", "iuid": "445e48b49c1846c780e1e603c3a4769a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/445e48b49c1846c780e1e603c3a4769a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/445e48b49c1846c780e1e603c3a4769a"}}, "title": "Colloidal dispersion of poly(ionic liquid)/Cu composite particles for protective surface coating against SAR-CoV-2.", "authors": [{"family": "Khorsand Kheirabad", "given": "Atefeh", "initials": "A"}, {"family": "Pan", "given": "Xuefeng", "initials": "X"}, {"family": "Long", "given": "Siwen", "initials": "S"}, {"family": "Kochovski", "given": "Zdravko", "initials": "Z"}, {"family": "Zhou", "given": "Shiqi", "initials": "S"}, {"family": "Lu", "given": "Yan", "initials": "Y"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Yuan", "given": "Jiayin", "initials": "J"}], "type": "journal article", "published": "2021-06-01", "journal": {"title": "Nano Sel", "issn": "2688-4011", "issn-l": null}, "abstract": "Herein, we report a waterproof anti-SARS-CoV-2 protective film prepared by spray-coating of an aqueous colloidal dispersion of poly(ionic liquid)/copper (PIL/Cu) composite nanoparticles onto a substrate. The PIL dispersion was prepared by suspension polymerization of 3-dodecyl-1-vinylimdiazolium bromide in water at 70\u00b0C. The copper acetate salt was added into the PIL nanoparticle dispersion and in situ reduced into copper nanoparticles anchoring onto the PIL nanoparticles. Despite being waterborne, the PIL in bulk is intrinsically insoluble in water and the formed coating is stable in water. The formed surface coating by PIL/copper composite nanoparticles was able to deactivate SARS-CoV-2 virions by 90.0% in 30 minutes and thus may effectively prevent the spread of SARS-CoV-2 through surface contact. This method may provide waterborne dispersions for a broad range of antivirus protective surface coatings for both outdoor and indoor applications.", "doi": "10.1002/nano.202100069", "pmid": "34485979", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "NANO202100069"}, {"db": "pmc", "key": "PMC8242609"}], "notes": [], "created": "2021-09-09T05:33:55.285Z", "modified": "2021-09-09T05:34:12.458Z"}, {"entity": "publication", "iuid": "45136e9ac839441891070f8397ec88a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/45136e9ac839441891070f8397ec88a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/45136e9ac839441891070f8397ec88a0"}}, "title": "Tracheotomy in COVID-19 patients: A retrospective study on complications and timing.", "authors": [{"family": "Pauli", "given": "Nina", "initials": "N", "orcid": "0000-0002-4058-2477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42734bf19ccc426986c4c7360d467655.json"}}, {"family": "Eeg-Olofsson", "given": "M\u00e5ns", "initials": "M"}, {"family": "Bergquist", "given": "Henrik", "initials": "H"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Laryngoscope Investig Otolaryngol", "issn": "2378-8038", "volume": "6", "issue": "3", "pages": "446-452", "issn-l": null}, "abstract": "The aim of this study was to analyze the timing of tracheotomy and the duration of mechanical ventilation and stay in the intensive care unit (ICU) in patients with COVID-19 infection. Furthermore, we aimed to investigate tracheotomy complications and mortality.\n\nConsecutive patients with COVID-19 infection admitted to the Department of Infectious Diseases in Gothenburg, Sweden were identified. Medical records were retrieved and retrospectively assessed.\n\nOne hundred eighty-eight patients with COVID-19 infection requiring hospital care were identified. Of these, 116 patients were critically ill and intubated, and 55 patients underwent tracheotomy. The mean time from endotracheal intubation to tracheotomy was 12 days (range 5-28 days). There was a correlation between the timing of tracheotomy and the duration of mechanical ventilation, where a shorter time between intubation and tracheotomy was correlated with a shorter duration of mechanical ventilation (r .58, P < .001), and a correlation was identified between the timing of tracheotomy and the duration of ICU stay (r .52, P < .001). Perioperative hypoxemia was registered in 9% of tracheotomies performed, whereas postoperative bleeding was observed in 27% of cases, the majority of which were minor.\n\nThis retrospective cohort study indicates that early tracheotomy is related to a reduced need for mechanical ventilation and a shorter duration of stay in the ICU in severe cases of COVID-19 disease. Complications during and after tracheotomy in this specific cohort included risk perioperative hypoxia and postoperative bleeding. Prospective randomized controlled trials would be of value to confirm these findings.\n\n4, Case series.", "doi": "10.1002/lio2.560", "pmid": "34195366", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "LIO2560"}, {"db": "pmc", "key": "PMC8223451"}], "notes": [], "created": "2021-07-05T14:30:43.050Z", "modified": "2021-07-05T14:30:43.104Z"}, {"entity": "publication", "iuid": "e851543e1e4e4893aeb160d7e7db8ac5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e851543e1e4e4893aeb160d7e7db8ac5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e851543e1e4e4893aeb160d7e7db8ac5"}}, "title": "Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study.", "authors": [{"family": "COVIDSurg Collaborative", "given": "", "initials": ""}, {"family": "GlobalSurg Collaborative", "given": "", "initials": ""}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Anaesthesia", "issn": "1365-2044", "issn-l": "0003-2409", "volume": "76", "issue": "6", "pages": "748-758"}, "abstract": "Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre-operative SARS-CoV-2 infection were compared with those without previous SARS-CoV-2 infection. The primary outcome measure was 30-day postoperative mortality. Logistic regression models were used to calculate adjusted 30-day mortality rates stratified by time from diagnosis of SARS-CoV-2 infection to surgery. Among 140,231 patients (116 countries), 3127 patients (2.2%) had a pre-operative SARS-CoV-2 diagnosis. Adjusted 30-day mortality in patients without SARS-CoV-2 infection was 1.5% (95%CI 1.4-1.5). In patients with a pre-operative SARS-CoV-2 diagnosis, mortality was increased in patients having surgery within 0-2 weeks, 3-4 weeks and 5-6 weeks of the diagnosis (odds ratio (95%CI) 4.1 (3.3-4.8), 3.9 (2.6-5.1) and 3.6 (2.0-5.2), respectively). Surgery performed \u2265 7 weeks after SARS-CoV-2 diagnosis was associated with a similar mortality risk to baseline (odds ratio (95%CI) 1.5 (0.9-2.1)). After a \u2265 7 week delay in undertaking surgery following SARS-CoV-2 infection, patients with ongoing symptoms had a higher mortality than patients whose symptoms had resolved or who had been asymptomatic (6.0% (95%CI 3.2-8.7) vs. 2.4% (95%CI 1.4-3.4) vs. 1.3% (95%CI 0.6-2.0), respectively). Where possible, surgery should be delayed for at least 7 weeks following SARS-CoV-2 infection. Patients with ongoing symptoms \u2265 7 weeks from diagnosis may benefit from further delay.", "doi": "10.1111/anae.15458", "pmid": "33690889", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8206995"}], "notes": [], "created": "2021-03-17T12:29:40.454Z", "modified": "2023-06-19T15:14:42.544Z"}, {"entity": "publication", "iuid": "e1d3160ba88043cb8f709061c798b507", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e1d3160ba88043cb8f709061c798b507.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e1d3160ba88043cb8f709061c798b507"}}, "title": "The impact of COVID-19 pandemic on vascular registries and clinical trials.", "authors": [{"family": "Aziz", "given": "Faisal", "initials": "F"}, {"family": "Behrendt", "given": "Christian-Alexander", "initials": "CA"}, {"family": "Sullivan", "given": "Kaity", "initials": "K"}, {"family": "Beck", "given": "Adam W", "initials": "AW"}, {"family": "Beiles", "given": "C Barry", "initials": "CB"}, {"family": "Boyle", "given": "Jon R", "initials": "JR"}, {"family": "Mani", "given": "Kevin", "initials": "K"}, {"family": "Benson", "given": "Ruth A", "initials": "RA"}, {"family": "Wohlauer", "given": "Max V", "initials": "MV"}, {"family": "Khashram", "given": "Manar", "initials": "M"}, {"family": "Jorgensen", "given": "Jens Eldrup", "initials": "JE"}, {"family": "Lemmon", "given": "Gary W", "initials": "GW"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Semin Vasc Surg", "issn": "1558-4518", "volume": "34", "issue": "2", "pages": "28-36", "issn-l": null}, "abstract": "Quality improvement programs and clinical trial research experienced disruption due to the coronavirus disease 2019 (COVID-19) pandemic. Vascular registries showed an immediate impact with significant declines in second-quarter vascular procedure volumes witnessed across Europe and the United States. To better understand the magnitude and impact of the pandemic, organizations and study groups sent grass roots surveys to vascular specialists for needs assessment. Several vascular registries responded quickly by insertion of COVID-19 variables into their data collection forms. More than 80% of clinical trials have been reported delayed or not started due to factors that included loss of enrollment from patient concerns or mandated institutional shutdowns, weighing the risk of trial participation on patient safety. Preliminary data of patients undergoing vascular surgery with active COVID-19 infection show inferior outcomes (morbidity) and increased mortality. Disease-specific vascular surgery study collaboratives about COVID-19 were created for the desire to study the disease in a more focused manner than possible through registry outcomes. This review describes the pandemic effect on multiple VASCUNET registries including Germany (GermanVasc), Sweden (SwedVasc), United Kingdom (UK National Vascular Registry), Australia and New Zealand (bi-national Australasian Vascular Audit), as well as the United States (Society for Vascular Surgery Vascular Quality Initiative). We will highlight the continued collaboration of VASCUNET with the Vascular Quality Initiative in the International Consortium of Vascular Registries as part of the Medical Device Epidemiology Network coordinated registry network. Vascular registries must remain flexible and responsive to new and future real-world problems affecting vascular patients.", "doi": "10.1053/j.semvascsurg.2021.04.001", "pmid": "34144744", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0895-7967(21)00025-9"}, {"db": "pmc", "key": "PMC8137351"}], "notes": [], "created": "2021-06-28T18:29:11.034Z", "modified": "2021-06-28T18:29:11.056Z"}, {"entity": "publication", "iuid": "0ce9c878343748629bbc7bda9bcda93a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ce9c878343748629bbc7bda9bcda93a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ce9c878343748629bbc7bda9bcda93a"}}, "title": "The impact of COVID-19 lockdown on dengue transmission in Sri Lanka; A natural experiment for understanding the influence of human mobility.", "authors": [{"family": "Liyanage", "given": "Prasad", "initials": "P", "orcid": "0000-0002-5174-7644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bee7bfe3b6e2476b8337f0c22925a874.json"}}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J", "orcid": "0000-0003-4030-0449", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5f15a200e614e10a8d972285750e745.json"}}, {"family": "Tissera", "given": "Hasitha Aravinda", "initials": "HA", "orcid": "0000-0002-9379-1002", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8bcd2f470e2f4dfcb5bbd2a1b8b50b26.json"}}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "PLoS Negl Trop Dis", "issn": "1935-2735", "issn-l": null, "volume": "15", "issue": "6", "pages": "e0009420"}, "abstract": "Dengue is one of the major public health problems in Sri Lanka. Its outbreak pattern depends on a multitude of drivers, including human mobility. Here we evaluate the impact of COVID-19 related mobility restriction (lockdown) on the risk of dengue in Sri Lanka.\n\nTwo-stage hierarchical models were fitted using an interrupted time-series design based on the notified dengue cases, January 2015 to July 2020. In the first stage model, the district level impact was estimated using quasi-Poisson regression models while accounting for temporal trends. Estimates were pooled at zonal and national levels in the second stage model using meta-analysis. The influence of the extended period of school closure on dengue in children in the western province was compared to adults.\n\nStatistically significant and homogeneous reduction of dengue risk was observed at all levels during the lockdown. Overall an 88% reduction in risk (RR 0.12; 95% CI from 0.08 to 0.17) was observed at the national level. The highest impact was observed among children aged less than 19 years showing a 92% reduction (RR 0.8; 95% CI from 0.03 to 0.25). We observed higher impact in the dry zone having 91% reduction (RR 0.09; 95% CI from 0.05 to 0.15) compared to wet zone showing 83% reduction (RR 0.17; 95% CI from 0.09 to 0.30). There was no indication that the overall health-seeking behaviour for dengue had a substantial influence on these estimates.\n\nThis study offers a broad understanding of the change in risk of dengue during the COVID-19 pandemic and associated mobility restrictions in Sri Lanka. The analysis using the mobility restrictions as a natural experiment suggests mobility patterns to be a very important driver of dengue transmission.", "doi": "10.1371/journal.pntd.0009420", "pmid": "34111117", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8192006"}, {"db": "pii", "key": "PNTD-D-20-02142"}], "notes": [], "created": "2021-06-11T05:04:37.672Z", "modified": "2023-06-19T15:04:40.021Z"}, {"entity": "publication", "iuid": "153dd3f5eadd46babafb9997a4ebe1ba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/153dd3f5eadd46babafb9997a4ebe1ba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/153dd3f5eadd46babafb9997a4ebe1ba"}}, "title": "The SIOG COVID-19 working group recommendations on the rollout of COVID-19 vaccines among older adults with cancer.", "authors": [{"family": "Mislang", "given": "Anna Rachelle", "initials": "AR"}, {"family": "Soto-Perez-de-Celis", "given": "Enrique", "initials": "E"}, {"family": "Russo", "given": "Chiara", "initials": "C"}, {"family": "Colloca", "given": "Giuseppe", "initials": "G"}, {"family": "Williams", "given": "Grant R", "initials": "GR"}, {"family": "O'Hanlon", "given": "Shane", "initials": "S"}, {"family": "Cooper", "given": "Lisa", "initials": "L"}, {"family": "O'Donovan", "given": "Anita", "initials": "A"}, {"family": "Audisio", "given": "Riccardo A", "initials": "RA"}, {"family": "Cheung", "given": "Kwok-Leung", "initials": "KL"}, {"family": "Sarri\u00f3", "given": "Regina Giron\u00e9s", "initials": "RG"}, {"family": "Stauder", "given": "Reinhard", "initials": "R"}, {"family": "Jaklitsch", "given": "Michael", "initials": "M"}, {"family": "Cairo", "given": "Clarito", "initials": "C"}, {"family": "Gil", "given": "Luiz Antonio", "initials": "LA"}, {"family": "Sattar", "given": "Schroder", "initials": "S"}, {"family": "Kantilal", "given": "Kumud", "initials": "K"}, {"family": "Loh", "given": "Kah Poh", "initials": "KP"}, {"family": "Lichtman", "given": "Stuart M", "initials": "SM"}, {"family": "Brain", "given": "Etienne", "initials": "E"}, {"family": "Wildiers", "given": "Hans", "initials": "H"}, {"family": "Kanesvaran", "given": "Ravindran", "initials": "R"}, {"family": "Battisti", "given": "Nicol\u00f2 Matteo Luca", "initials": "NML"}], "type": "letter", "published": "2021-06-00", "journal": {"title": "J Geriatr Oncol", "issn": "1879-4076", "volume": "12", "issue": "5", "pages": "848-850", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jgo.2021.03.003", "pmid": "33715995", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1879-4068(21)00057-6"}, {"db": "pmc", "key": "PMC7934668"}], "notes": [], "created": "2021-03-17T07:13:04.746Z", "modified": "2021-11-18T12:48:50.459Z"}, {"entity": "publication", "iuid": "cb5b53f903dd43ac81c6315419c96fe0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cb5b53f903dd43ac81c6315419c96fe0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cb5b53f903dd43ac81c6315419c96fe0"}}, "title": "The New Totalitarians: The Swedish COVID-19 strategy and the implications of consensus culture and media policy for public health.", "authors": [{"family": "Lindstr\u00f6m", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "SSM Popul Health", "issn": "2352-8273", "issn-l": null, "volume": "14", "issue": null, "pages": "100788"}, "abstract": "The aim is to discuss implications of consensus culture in combination with media policy in Sweden with regard to the Swedish COVID-19 strategy in the spring of 2020.\r\n\r\nInvestigation of prerequisites for scrutiny by the Swedish mass media of the Swedish strategy in the spring of 2020 based on discussion regarding consensus culture, media structure and postmodernism in science, politics and administration.\r\n\r\nThe Swedish strategy entailed strong initial confidence in herd immunity (although not officially stated), individual responsibility, evidence based medicine and substantial neglect to cooperate internationally. The strategy may be regarded partly as a result of the postmodern view of science and society predominant in Sweden. A tradition of top down consensus culture combined with mass media's financial and partly structural dependence of the state may help explain the comparative lack of critical questions regarding the strategy at the press conferences in the spring of 2020.\r\n\r\nMass media in Sweden should become more financially and structurally independent of the state. The reporting by Swedish media in the spring of 2020 should be subject to peer-reviewed research.", "doi": "10.1016/j.ssmph.2021.100788", "pmid": "34136630", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2352-8273(21)00063-X"}, {"db": "pmc", "key": "PMC8182112"}], "notes": [], "created": "2021-06-28T18:41:53.111Z", "modified": "2021-07-14T09:09:06.291Z"}, {"entity": "publication", "iuid": "db4f6196f40a4023837567fb80842949", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db4f6196f40a4023837567fb80842949.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db4f6196f40a4023837567fb80842949"}}, "title": "T cell immunity to SARS-CoV-2.", "authors": [{"family": "Niessl", "given": "Julia", "initials": "J"}, {"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Semin Immunol", "issn": "1096-3618", "pages": "101505", "volume": "55", "issn-l": null}, "abstract": "Exceptional efforts have been undertaken to shed light into the biology of adaptive immune responses to SARS-CoV-2. T cells occupy a central role in adaptive immunity to mediate helper functions to different arms of the immune system and are fundamental to mediate protection, control, and clearance of most viral infections. Even though many questions remain unsolved, there is a growing literature linking specific T cell characteristics to differential COVID-19 severity and vaccine outcome. In this review, we summarize our current understanding of CD4+ and CD8+ T cell responses in acute and convalescent COVID-19. Further, we discuss the T cell literature coupled to pre-existing immunity and vaccines and highlight the need to look beyond blood to fully understand how T cells function in the tissue space.", "doi": "10.1016/j.smim.2021.101505", "pmid": "34711489", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8529278"}, {"db": "pii", "key": "S1044-5323(21)00036-1"}], "notes": [], "created": "2021-11-01T19:51:00.402Z", "modified": "2023-01-13T13:25:49.721Z"}, {"entity": "publication", "iuid": "63d6d2d5319f47f4894f5efeed7eef39", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63d6d2d5319f47f4894f5efeed7eef39.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63d6d2d5319f47f4894f5efeed7eef39"}}, "title": "Sleep problems during COVID-19 pandemic and its' association to psychological distress: A systematic review and meta-analysis.", "authors": [{"family": "Alimoradi", "given": "Zainab", "initials": "Z"}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Tsang", "given": "Hector W H", "initials": "HWH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Haghayegh", "given": "Shahab", "initials": "S"}, {"family": "Ohayon", "given": "Maurice M", "initials": "MM"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "issn-l": null, "volume": "36", "issue": null, "pages": "100916"}, "abstract": "The emerging novel coronavirus disease 2019 (COVID-19) has become one of the leading cause of deaths worldwide in 2020. The present systematic review and meta-analysis estimated the magnitude of sleep problems during the COVID-19 pandemic and its relationship with psychological distress.\r\n\r\nFive academic databases ( Scopus, PubMed Central, ProQuest, ISI Web of Knowledge, and Embase) were searched. Observational studies including case-control studies and cross-sectional studies were included if relevant data relationships were reported (i.e., sleep assessed utilizing the Pittsburgh Sleep Quality Index or Insomnia Severity Index). All the studies were English, peer-reviewed papers published between December 2019 and February 2021. PROSPERO registration number: CRD42020181644.\r\n\r\n168 cross-sectional, four case-control, and five longitudinal design papers comprising 345,270 participants from 39 countries were identified. The corrected pooled estimated prevalence of sleep problems were 31% among healthcare professionals, 18% among the general population, and 57% among COVID-19 patients (all p-values < 0.05). Sleep problems were associated with depression among healthcare professionals, the general population, and COVID-19 patients, with Fisher's Z scores of -0.28, -0.30, and -0.36, respectively. Sleep problems were positively (and moderately) associated with anxiety among healthcare professionals, the general population, and COVID-19 patients, with Fisher's z scores of 0.55, 0.48, and 0.49, respectively.\r\n\r\nSleep problems appear to have been common during the ongoing COVID-19 pandemic. Moreover, sleep problems were found to be associated with higher levels of psychological distress. With the use of effective programs treating sleep problems, psychological distress may be reduced. Vice versa, the use of effective programs treating psychological distress, sleep problems may be reduced.\r\n\r\nThe present study received no funding.", "doi": "10.1016/j.eclinm.2021.100916", "pmid": "34131640", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(21)00196-6"}, {"db": "pmc", "key": "PMC8192091"}], "notes": [], "created": "2021-06-17T07:35:43.630Z", "modified": "2021-07-14T09:12:28.694Z"}, {"entity": "publication", "iuid": "fc24ed82a6ff4d4ca6ec337815354701", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc24ed82a6ff4d4ca6ec337815354701.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc24ed82a6ff4d4ca6ec337815354701"}}, "title": "Response by Mackman et al to Letter Regarding Article, \"Patients With COVID-19 Have Elevated Levels of Circulating Extracellular Vesicle Tissue Factor Activity That Is Associated With Severity and Mortality-Brief Report\".", "authors": [{"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Hisada", "given": "Yohei", "initials": "Y"}, {"family": "Grover", "given": "Steven P", "initials": "SP"}, {"family": "Rosell", "given": "Axel", "initials": "A"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "von Meijenfeldt", "given": "Fien", "initials": "F"}, {"family": "Aguilera", "given": "Katherina", "initials": "K"}, {"family": "Lisman", "given": "Ton", "initials": "T"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "letter", "published": "2021-06-00", "journal": {"title": "Arterioscler Thromb Vasc Biol", "issn": "1524-4636", "volume": "41", "issue": "6", "pages": "e381-e382", "issn-l": null}, "abstract": null, "doi": "10.1161/ATVBAHA.121.316203", "pmid": "34038165", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-29T15:33:21.987Z", "modified": "2021-05-29T15:33:21.996Z"}, {"entity": "publication", "iuid": "bd5c6eab824541e4a1713a503582837f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bd5c6eab824541e4a1713a503582837f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bd5c6eab824541e4a1713a503582837f"}}, "title": "Rehabilitation needs and mortality associated with the Covid-19 pandemic: a population-based study of all hospitalised and home-healthcare individuals in a Swedish healthcare region.", "authors": [{"family": "Divanoglou", "given": "Anestis", "initials": "A"}, {"family": "Samuelsson", "given": "Assoc Prof Kersti", "initials": "APK"}, {"family": "Sj\u00f6dahl", "given": "Prof Emer Rune", "initials": "PER"}, {"family": "Andersson", "given": "Christer", "initials": "C"}, {"family": "Levi", "given": "Prof Richard", "initials": "PR"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "issn-l": null, "volume": "36", "issue": null, "pages": "100920"}, "abstract": "This first report of the Link\u00f6ping Covid-19 Study (LinCoS) aimed at determination of Covid-19-associated mortality, impairments, activity and participation limitations denoting rehabilitation needs four months after discharge from hospital.\r\n\r\nAn ambidirectional population-based cohort study including all confirmed Covid-19 cases admitted to hospital during 1/03-31/05 and those living in home healthcare settings identified through a regional registry and evaluated through medical records, including WHO Clinical Progression Scale (CPS). All patients discharged from hospital were followed-up by structured telephone interview at 4 months post-discharge. Respondents indicated any new or aggravated persisting problems in any of 25 body functions and 12 activity/participation items and rated them for impact on daily life.\r\n\r\nOut of 734 hospitalised patients, 149 were excluded, 125 died, and 460 were alive at 4-month follow-up of whom 433 (94.1%) were interviewed. In total, 40% reported impairments and activity/participation limitations affecting daily life and warranted further multi-professional rehabilitation assessment, predominantly those with severe disease and a considerable proportion of those with moderate disease. Cognitive and affective impairments were equally common in all groups and were reported by 20-40% of cases. Limb weakness was reported by 31%, with CPS 7-9 being four times more likely to report this problem as compared to CPS 4-5. 26% of those working or studying reported difficulties returning to these activities, this being 3.5 times more likely in CPS 7-9 as compared to CPS 4-5. 25% reported problems walking >1 km, with CPS 7-9 over three times more likely to report this as compared to the other two sub-groups. 90-day mortality rate of Covid-19 associated deaths was 15.1%.\r\n\r\nMost rehabilitation needs after Covid-19 involved higher cerebral dysfunction both in patients with moderate and severe disease. This should be considered when designing services aiming at minimizing long-term disability.\r\n\r\nALF grant and Region \u00d6sterg\u00f6tland.", "doi": "10.1016/j.eclinm.2021.100920", "pmid": "34095795", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(21)00200-5"}, {"db": "pmc", "key": "PMC8164661"}], "notes": [], "created": "2021-06-08T09:00:47.968Z", "modified": "2021-07-14T09:11:25.676Z"}, {"entity": "publication", "iuid": "85fe5abcf3b7455493fc233a38c9d883", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/85fe5abcf3b7455493fc233a38c9d883.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/85fe5abcf3b7455493fc233a38c9d883"}}, "title": "Proteome profiling of recombinant DNase therapy in reducing NETs and aiding recovery in COVID-19 patients", "authors": [{"family": "Fisher", "given": "Jane", "initials": "J"}, {"family": "Mohanty", "given": "Tirthankar", "initials": "T"}, {"family": "Karlsson", "given": "Christofer", "initials": "C"}, {"family": "Khademi", "given": "S M Hossein", "initials": "SMH"}, {"family": "Malmstr\u00f6m", "given": "Erik", "initials": "E"}, {"family": "Frigyesi", "given": "Attila", "initials": "A"}, {"family": "Nordenfelt", "given": "Pontus", "initials": "P"}, {"family": "Malmstrom", "given": "Johan", "initials": "J"}, {"family": "Linder", "given": "Adam", "initials": "A"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "Molecular & Cellular Proteomics", "issn": "1535-9476", "issn-l": null, "volume": null, "issue": null, "pages": "100113"}, "abstract": "Severe COVID-19 can result in pneumonia and acute respiratory failure. Accumulation of mucus in the airways is a hall mark of the disease and can result in hypoxemia. Here, we show that quantitative proteome analysis of the sputum from severe COVID-19 patients reveal high levels of neutrophil extracellular trap(s) (NETs) components, which was confirmed by microscopy. Extracellular DNA from excessive NET formation can increase sputum viscosity and can lead to acute respiratory distress syndrome (ARDS). Recombinant human DNase (rhDNase/Pulmozyme) has been shown to be beneficial in reducing sputum viscosity and improve lung function. We treated 5 COVID-19 patients presenting acute symptoms with clinically approved aerosolized Pulmozyme. No adverse reactions to the drug were seen, and improved oxygen saturation and recovery in all severely ill COVID-19 patients was observed after therapy. Immunofluorescence and proteome analysis of sputum and blood plasma samples after treatment revealed a marked reduction of NETs and a set of statistically significant proteome changes that indicate reduction of haemorrhage, plasma leakage and inflammation in the airways, and reduced systemic inflammatory state in the blood plasma of patients. Taken together, the results indicate that NETs contribute to acute respiratory failure in COVID-19 and that degrading NETs may reduce dependency on external high flow oxygen therapy in patients. Targeting NETs using rhDNase may have significant therapeutic implications in COVID-19 disease and warrants further studies.", "doi": "10.1016/j.mcpro.2021.100113", "pmid": "34139362", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S1535-9476(21)00085-2"}, {"db": "pmc", "key": "PMC8205261"}, {"db": "PRIDE", "key": "https://www.ebi.ac.uk/pride/archive/projects/PXD021197", "description": "COVID-19 proteome profiling reveals resolution of inflammatory pathways and respiratory distress after DNase treatment"}], "notes": [], "created": "2021-06-28T18:31:04.166Z", "modified": "2021-11-18T13:36:33.841Z"}, {"entity": "publication", "iuid": "a82bd6da695c4af2b35286616494696c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a82bd6da695c4af2b35286616494696c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a82bd6da695c4af2b35286616494696c"}}, "title": "Prevalence of SARS-CoV-2 in Communities Through Wastewater Surveillance\u2014a Potential Approach for Estimation of Disease Burden", "authors": [{"family": "Bhattacharya", "given": "Prosun", "initials": "P", "orcid": "0000-0003-4350-9950", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/06f71013630d4ed08a8672a7e86ce6bf.json"}}, {"family": "Kumar", "given": "Manish", "initials": "M"}, {"family": "Islam", "given": "Md Tahmidul", "initials": "MT"}, {"family": "Haque", "given": "Rehnuma", "initials": "R"}, {"family": "Chakraborty", "given": "Sudip", "initials": "S"}, {"family": "Ahmad", "given": "Arslan", "initials": "A"}, {"family": "Niazi", "given": "Nabeel Khan", "initials": "NK"}, {"family": "Cetecioglu", "given": "Zeynep", "initials": "Z"}, {"family": "Nilsson", "given": "David", "initials": "D"}, {"family": "Ijumulana", "given": "Julian", "initials": "J"}, {"family": "van der Voorn", "given": "Tom", "initials": "T"}, {"family": "Jakariya", "given": "Md", "initials": "M"}, {"family": "Hossain", "given": "Maqsud", "initials": "M"}, {"family": "Ahmed", "given": "Firoz", "initials": "F"}, {"family": "Rahman", "given": "Mahbubur", "initials": "M"}, {"family": "Akter", "given": "Nargis", "initials": "N"}, {"family": "Johnston", "given": "Dara", "initials": "D"}, {"family": "Ahmed", "given": "Kazi Matin", "initials": "KM"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "Curr Pollut Rep", "issn": "2198-6592", "issn-l": null, "volume": "7", "issue": "2", "pages": "160-166"}, "abstract": "The episodic outbreak of COVID-19 due to SARS-CoV-2 is severely affecting the economy, and the global count of infected patients is increasing. The actual number of patients had been underestimated due to limited facilities for testing as well as asymptomatic nature of the expression of COVID-19 on individual basis. Tragically, for emerging economies with high population density, the situation has been more complex due to insufficient testing facilities for diagnosis of the disease. However, the recent reports about persistent shedding of viral RNA of SARS-CoV-2 in the human feces have created a possibility to track the prevalence and trends of the disease in communities, known as wastewater-based epidemiology (WBE). In this article, we highlight the current limitations and future prospects for WBE to manage pandemics.", "doi": "10.1007/s40726-021-00178-4", "pmid": "33842197", "labels": {"Research Area: Environmental virus profiling": null, "Funder: KAW/SciLifeLab": null, "Type: Review": null}, "xrefs": [{"db": "pii", "key": "178"}, {"db": "pmc", "key": "PMC8021931"}], "notes": [], "created": "2021-04-13T09:40:35.469Z", "modified": "2021-06-18T08:45:52.985Z"}, {"entity": "publication", "iuid": "f09cc223d49a4f3781c4d702e7d588fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f09cc223d49a4f3781c4d702e7d588fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f09cc223d49a4f3781c4d702e7d588fc"}}, "title": "Preterm Birth and Stillbirth During the COVID-19 Pandemic in Sweden: A Nationwide Cohort Study.", "authors": [{"family": "Pasternak", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-2097-8466", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c3b2692f334845c184219da7da7483d2.json"}}, {"family": "Neovius", "given": "Martin", "initials": "M", "orcid": "0000-0003-2300-3055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78e60d3149ce4ac994ddeaa441514ef6.json"}}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Ahlberg", "given": "Mia", "initials": "M", "orcid": "0000-0001-8612-6277", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4bb9a2d40e1478097dc3a95c6a8c9f3.json"}}, {"family": "Norman", "given": "Mikael", "initials": "M", "orcid": "0000-0003-4191-3781", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5346954396864ffbb8a1380e15c7dba7.json"}}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF", "orcid": "0000-0003-1024-5602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1d5e45881a7469ca20a0eb360d891cc.json"}}, {"family": "Stephansson", "given": "Olof", "initials": "O", "orcid": "0000-0003-1528-4563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39af50356a574c80ba6bd2227ecb5cf5.json"}}], "type": "letter", "published": "2021-06-00", "journal": {"title": "Ann Intern Med", "issn": "1539-3704", "volume": "174", "issue": "6", "pages": "873-875", "issn-l": "0003-4819"}, "abstract": null, "doi": "10.7326/M20-6367", "pmid": "33428442", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7808327"}], "notes": [], "created": "2023-01-05T09:33:03.361Z", "modified": "2023-01-05T09:33:20.337Z"}, {"entity": "publication", "iuid": "ffa3b7d3a56044fc9a89e408e7db2859", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ffa3b7d3a56044fc9a89e408e7db2859.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ffa3b7d3a56044fc9a89e408e7db2859"}}, "title": "Parkinson's Disease and Post-COVID-19 Syndrome: The Parkinson's Long-COVID Spectrum.", "authors": [{"family": "Leta", "given": "Valentina", "initials": "V", "orcid": "0000-0002-5794-7540", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15265d9377c342df8506ee8a06708525.json"}}, {"family": "Rodr\u00edguez-Violante", "given": "Mayela", "initials": "M", "orcid": "0000-0002-6041-9941", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a434345ba2d4075913a2af5b00e318a.json"}}, {"family": "Abundes", "given": "Arturo", "initials": "A"}, {"family": "Rukavina", "given": "Katarina", "initials": "K"}, {"family": "Teo", "given": "James T", "initials": "JT"}, {"family": "Falup-Pecurariu", "given": "Cristian", "initials": "C"}, {"family": "Irincu", "given": "Laura", "initials": "L"}, {"family": "Rota", "given": "Silvia", "initials": "S"}, {"family": "Bhidayasiri", "given": "Roongroj", "initials": "R", "orcid": "0000-0002-6901-2064", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78c370775b434ae281b3a0e57367686c.json"}}, {"family": "Storch", "given": "Alexander", "initials": "A"}, {"family": "Odin", "given": "Per", "initials": "P"}, {"family": "Antonini", "given": "Angelo", "initials": "A", "orcid": "0000-0003-1040-2807", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/02f966fef60c46a9aa7be04923ea0a2a.json"}}, {"family": "Ray Chaudhuri", "given": "Kallol", "initials": "K", "orcid": "0000-0003-2815-0505", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92bb30651ec5484f8a1364222efcce5a.json"}}], "type": "letter", "published": "2021-06-00", "journal": {"title": "Mov Disord", "issn": "1531-8257", "issn-l": null, "volume": "36", "issue": "6", "pages": "1287-1289"}, "abstract": null, "doi": "10.1002/mds.28622", "pmid": "33890344", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8250675"}], "notes": [], "created": "2021-04-29T16:10:06.261Z", "modified": "2023-01-13T13:24:33.196Z"}, {"entity": "publication", "iuid": "088b14ba53f7445899eef52f4f1addf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/088b14ba53f7445899eef52f4f1addf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/088b14ba53f7445899eef52f4f1addf3"}}, "title": "Orthodontic retention: what's on the horizon?", "authors": [{"family": "Littlewood", "given": "Simon J", "initials": "SJ"}, {"family": "Dalci", "given": "Oyku", "initials": "O"}, {"family": "Dolce", "given": "Calogero", "initials": "C"}, {"family": "Holliday", "given": "L Shannon", "initials": "LS"}, {"family": "Naraghi", "given": "Sasan", "initials": "S"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Br Dent J", "issn": "1476-5373", "volume": "230", "issue": "11", "pages": "760-764", "issn-l": null}, "abstract": "Orthodontic retention remains one of the great challenges in orthodontics. In this article, we discuss what is on the horizon to help address this challenge, including biological approaches to reduce relapse, treating patients without using retainers, technological developments, personalised medicine and the impact of COVID-19 on approaches to orthodontic retention.", "doi": "10.1038/s41415-021-2937-8", "pmid": "34117435", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41415-021-2937-8"}], "notes": [], "created": "2021-06-14T06:33:28.931Z", "modified": "2021-06-14T06:33:28.938Z"}, {"entity": "publication", "iuid": "638334507f99412a8f18438594fcaacd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/638334507f99412a8f18438594fcaacd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/638334507f99412a8f18438594fcaacd"}}, "title": "Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2", "authors": [{"family": "Hassan", "given": "Sk Sarif", "initials": "SS"}, {"family": "Attrish", "given": "Diksha", "initials": "D"}, {"family": "Ghosh", "given": "Shinjini", "initials": "S"}, {"family": "Choudhury", "given": "Pabitra Pal", "initials": "PP"}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN"}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA"}, {"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Uhal", "given": "Bruce D", "initials": "BD"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Seyran", "given": "Murat", "initials": "M"}, {"family": "Pizzol", "given": "Damiano", "initials": "D"}, {"family": "Adadi", "given": "Parise", "initials": "P"}, {"family": "Soares", "given": "Antonio", "initials": "A"}, {"family": "Abd El-Aziz", "given": "Tarek Mohamed", "initials": "TM"}, {"family": "Kandimalla", "given": "Ramesh", "initials": "R"}, {"family": "Tambuwala", "given": "Murtaza M", "initials": "MM"}, {"family": "Azad", "given": "Gajendra Kumar", "initials": "GK"}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Baetas-da-Cruz", "given": "Wagner", "initials": "W"}, {"family": "Lal", "given": "Amos", "initials": "A"}, {"family": "Pal\u00f9", "given": "Giorgio", "initials": "G"}, {"family": "Takayama", "given": "Kazuo", "initials": "K"}, {"family": "Serrano-Aroca", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "Barh", "given": "Debmalya", "initials": "D"}, {"family": "Brufsky", "given": "Adam M", "initials": "AM"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "International Journal of Biological Macromolecules", "issn": "0141-8130", "volume": "181", "issue": null, "pages": "801-809", "issn-l": null}, "abstract": null, "doi": "10.1016/j.ijbiomac.2021.03.199", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-19T10:37:28.411Z", "modified": "2021-04-19T10:37:28.436Z"}, {"entity": "publication", "iuid": "c80dd926ac8d4140824baeb0ba34e4e5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c80dd926ac8d4140824baeb0ba34e4e5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c80dd926ac8d4140824baeb0ba34e4e5"}}, "title": "Modest effects of dietary supplements during the COVID-19 pandemic: insights from 445 850 users of the COVID-19 Symptom Study app", "authors": [{"family": "Louca", "given": "Panayiotis", "initials": "P", "orcid": "0000-0001-5956-1433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44d3563d8537415488d45a381ccd0604.json"}}, {"family": "Murray", "given": "Benjamin", "initials": "B", "orcid": "0000-0002-8198-8131", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/633d9bf9646d4c07a6611f21e67dc798.json"}}, {"family": "Klaser", "given": "Kerstin", "initials": "K", "orcid": "0000-0002-5230-6939", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6eaf3d777b444dec814026eceb65de8c.json"}}, {"family": "Graham", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-4170-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f5f4e19812a46ed9e873732ec25e28d.json"}}, {"family": "Mazidi", "given": "Mohsen", "initials": "M", "orcid": "0000-0003-3059-229X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7d50a209c0b64f3b93703515c57f1334.json"}}, {"family": "Leeming", "given": "Emily R", "initials": "ER", "orcid": "0000-0002-0531-4901", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59a9e4a4912f451c861668efdd226c44.json"}}, {"family": "Thompson", "given": "Ellen", "initials": "E", "orcid": "0000-0003-2118-821X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6754739394b24a5c8f5db22905b22c3c.json"}}, {"family": "Bowyer", "given": "Ruth", "initials": "R", "orcid": "0000-0002-6941-8160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eebaf361c184499ca6729aa60cc0af3d.json"}}, {"family": "Drew", "given": "David A", "initials": "DA", "orcid": "0000-0002-8813-0816", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd3a2cffdc104f18b8684cf4f27d68b2.json"}}, {"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Merino", "given": "Jordi", "initials": "J", "orcid": "0000-0001-8312-1438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12ab049914a542b39affcfb4196861d2.json"}}, {"family": "Gomez", "given": "Maria", "initials": "M", "orcid": "0000-0001-6210-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e09e37219c4f42c8a7b3a982da523859.json"}}, {"family": "Mompeo", "given": "Olatz", "initials": "O", "orcid": "0000-0002-1754-6136", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2051c14cd79e43b3b1f168c7c896aa8a.json"}}, {"family": "Costeira", "given": "Ricardo", "initials": "R", "orcid": "0000-0002-8316-5219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f9a3632463540a4930b5f7ac70d0faa.json"}}, {"family": "Sudre", "given": "Carole H", "initials": "CH", "orcid": "0000-0001-5753-428X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c26472813fed4007a8757af771de1802.json"}}, {"family": "Gibson", "given": "Rachel", "initials": "R", "orcid": "0000-0002-5823-6468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/def9e18b28a34704b6d658bc0d82fa14.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74cf1f7094744ee289fa5df041e7cb5b.json"}}, {"family": "Ourselin", "given": "Sebastien", "initials": "S", "orcid": "0000-0002-5694-5340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74c7b9b1633144879042d198c7205656.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-7284-6767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeefbf47fd384d5390109fe1a903bd18.json"}}, {"family": "Berry", "given": "Sarah E", "initials": "SE", "orcid": "0000-0002-5819-5109", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90a2ad26c7694c379586df859629c77d.json"}}, {"family": "Valdes", "given": "Ana M", "initials": "AM", "orcid": "0000-0003-1141-4471", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25a57a383f7f42ad82558fa66564fdf9.json"}}, {"family": "Calder", "given": "Philip C", "initials": "PC", "orcid": "0000-0002-6038-710X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0057aacc763d4e448ba964c8c238a32b.json"}}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874802ae65824a90ba50eabdeabb8356.json"}}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "BMJ Nutr Prev Health", "issn": "2516-5542", "volume": "4", "issue": "1", "pages": "149-157", "issn-l": null}, "abstract": "Dietary supplements may ameliorate SARS-CoV-2 infection, although scientific evidence to support such a role is lacking. We investigated whether users of the COVID-19 Symptom Study app who regularly took dietary supplements were less likely to test positive for SARS-CoV-2 infection.\n\nApp-based community survey.\n\n445 850 subscribers of an app that was launched to enable self-reported information related to SARS-CoV-2 infection for use in the general population in the UK (n=372 720), the USA (n=45 757) and Sweden (n=27 373).\n\nSelf-reported regular dietary supplement usage (constant use during previous 3 months) in the first waves of the pandemic up to 31 July 2020.\n\nSARS-CoV-2 infection confirmed by viral RNA reverse transcriptase PCR test or serology test before 31 July 2020.\n\nIn 372 720 UK participants (175 652 supplement users and 197 068 non-users), those taking probiotics, omega-3 fatty acids, multivitamins or vitamin D had a lower risk of SARS-CoV-2 infection by 14% (95% CI (8% to 19%)), 12% (95% CI (8% to 16%)), 13% (95% CI (10% to 16%)) and 9% (95% CI (6% to 12%)), respectively, after adjusting for potential confounders. No effect was observed for those taking vitamin C, zinc or garlic supplements. On stratification by sex, age and body mass index (BMI), the protective associations in individuals taking probiotics, omega-3 fatty acids, multivitamins and vitamin D were observed in females across all ages and BMI groups, but were not seen in men. The same overall pattern of association was observed in both the US and Swedish cohorts.\n\nIn women, we observed a modest but significant association between use of probiotics, omega-3 fatty acid, multivitamin or vitamin D supplements and lower risk of testing positive for SARS-CoV-2. We found no clear benefits for men nor any effect of vitamin C, garlic or zinc. Randomised controlled trials are required to confirm these observational findings before any therapeutic recommendations can be made.", "doi": "10.1136/bmjnph-2021-000250", "pmid": "34308122", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjnph-2021-000250"}, {"db": "pmc", "key": "PMC8061565"}, {"db": "URL", "key": "https://covid.joinzoe.com", "description": "ZOE COVID Study website (providing information on raw data and data visualisations)"}, {"db": "URL", "key": "https://nutrition.bmj.com/content/4/1/149#supplementary-materials", "description": "Supplementary Information (includes information on relevant survey questions, summary statistics and flowcharts about the study)"}], "notes": [], "created": "2021-08-05T06:54:01.869Z", "modified": "2021-08-13T05:42:50.446Z"}, {"entity": "publication", "iuid": "aa000107f0344b9089a9673d588ec8f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aa000107f0344b9089a9673d588ec8f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aa000107f0344b9089a9673d588ec8f8"}}, "title": "Longitudinal variability in mortality predicts COVID-19 deaths.", "authors": [{"family": "Lundberg", "given": "Jon O", "initials": "JO", "orcid": "0000-0002-0174-5210", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78a32d00021a47db8c21c5a4f2419638.json"}}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3ee1510080704cf6a2a6972deb94123f.json"}}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Eur J Epidemiol", "issn": "1573-7284", "issn-l": "0393-2990", "volume": "36", "issue": "6", "pages": "599-603"}, "abstract": "Within Europe, death rates due to COVID-19 vary greatly, with some countries being severely hit while others to date are almost unaffected. This has created a heated debate in particular regarding how effective the different measures applied by the governments are in limiting the spread of the disease and ultimately deaths. It would be of considerable interest to pinpoint the factors that determine a country's susceptibility to a pandemic such as COVID-19. Here we present data demonstrating that mortality due to COVID-19 in a given country could have been predicted to some extent even before the pandemic hit Europe, simply by looking at longitudinal variability of death rates in the years preceding the current outbreak. The variability in death rates during the winter influenza seasons of 2015-2019 correlates to excess mortality in 2020 during the COVID-19 outbreak (Spearman's \u03c1 = 0.68, 95 % CI = 0.40-0.84, p < 0.001). In contrast, there was no correlation with age, population density, latitude, GNP, governmental health spending, number of intensive care beds, degree of urbanization, or rates of influenza vaccination. These data suggest an intrinsic susceptibility in certain countries to excess mortality associated with viral respiratory diseases including COVID-19.", "doi": "10.1007/s10654-021-00777-x", "pmid": "34218343", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10654-021-00777-x"}, {"db": "pmc", "key": "PMC8254667"}], "notes": [], "created": "2021-07-05T15:07:36.224Z", "modified": "2021-08-16T14:24:38.154Z"}, {"entity": "publication", "iuid": "90a791f266b04f929d7c174b43847ea9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90a791f266b04f929d7c174b43847ea9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90a791f266b04f929d7c174b43847ea9"}}, "title": "Immunogenicity of the BNT162b2 vaccine in frail or disabled nursing home residents: COVID-A study.", "authors": [{"family": "Salmer\u00f3n R\u00edos", "given": "Sergio", "initials": "S"}, {"family": "Mas Romero", "given": "Marta", "initials": "M"}, {"family": "Cort\u00e9s Zamora", "given": "Elisa Bel\u00e9n", "initials": "EB"}, {"family": "Tabernero Sahuquillo", "given": "Mar\u00eda Teresa", "initials": "MT"}, {"family": "Romero Rizos", "given": "Luis", "initials": "L"}, {"family": "S\u00e1nchez-Jurado", "given": "Pedro Manuel", "initials": "PM"}, {"family": "S\u00e1nchez-Nievas", "given": "Gin\u00e9s", "initials": "G"}, {"family": "Se\u00f1alada", "given": "Jos\u00e9 Joaqu\u00edn Blas", "initials": "JJB"}, {"family": "Garc\u00eda Nogueras", "given": "Inmaculada", "initials": "I"}, {"family": "Estrella Cazalla", "given": "Juan de Dios", "initials": "JdD"}, {"family": "Andr\u00e9s-Pretel", "given": "Fernando", "initials": "F"}, {"family": "Murillo Romero", "given": "Antonio", "initials": "A"}, {"family": "Lauschke", "given": "Volker Martin", "initials": "VM"}, {"family": "Stebbing", "given": "Justin", "initials": "J"}, {"family": "Abizanda", "given": "Pedro", "initials": "P"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "J Am Geriatr Soc", "issn": "0002-8614", "volume": "69", "issue": "6", "issn-l": null, "pages": "1441-1447"}, "abstract": "The safety and immunogenicity of the BNT162b2 coronavirus disease 2019 (COVID-19) vaccine in older adults with different frailty and disability profiles have not been well determined. Our objective was to analyze immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in older adults across frailty and disability profiles.\r\n\r\nMulticenter longitudinal cohort study.\r\n\r\nA total of 134 residents aged \u226565 years with different frailty and disability profiles in five long-term care facilities (LTCFs) in Albacete, Spain.\r\n\r\nResidents were administered two vaccine doses as per the label, and antibody levels were determined 21.9 days (SD 9.3) after both the first and second dose. Functional variables were assessed using activities of daily living (Barthel Index), and frailty status was determined with the FRAIL instrument. Cognitive status and comorbidity were also evaluated.\r\n\r\nMean age was 82.9 years (range 65-99), and 71.6% were female. The mean antibody titers in residents with and without previous COVID-19 infection were 49,878 AU/ml and 15,274 AU/ml, respectively (mean difference 34,604; 95% confidence interval [CI]: 27,699-41,509). No severe adverse reactions were observed, after either vaccine dose. Those with prevaccination COVID-19 had an increased antibody level after the vaccine (B = 31,337; 95% CI: 22,725-39,950; p < 0.001). Frailty, disability, older age, sex, cognitive impairment, or comorbidities were not associated with different antibody titers.\r\n\r\nThe BNT162b2 mRNA COVID-19 vaccine in older adults is safe and produces immunogenicity, independently of the frailty and disability profiles. Older adults in LTCFs should receive a COVID-19 vaccine.", "doi": "10.1111/jgs.17153", "pmid": "33768521", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8250586"}], "notes": [], "created": "2021-03-29T09:26:15.643Z", "modified": "2021-08-23T14:39:35.931Z"}, {"entity": "publication", "iuid": "885b12d94aef4f74a878db2b333fbae4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/885b12d94aef4f74a878db2b333fbae4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/885b12d94aef4f74a878db2b333fbae4"}}, "title": "Guest attendance data from 34 Swedish pre-schools and primary schools.", "authors": [{"family": "Eriksson", "given": "Mattias", "initials": "M"}, {"family": "Malefors", "given": "Christopher", "initials": "C"}, {"family": "Secondi", "given": "Luca", "initials": "L"}, {"family": "Marchetti", "given": "Stefano", "initials": "S"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Data Brief", "issn": "2352-3409", "issn-l": null, "volume": "36", "issue": null, "pages": "107138"}, "abstract": "This data article describes 34 datasets, compiled into one table, describing guest attendance at lunch meal servings in Swedish public schools and preschools. Fifteen of the schools and all 16 of the preschools covered belong to one municipality, while the remaining three schools belong to two other municipalities, all located in central Sweden. Data on number of plates was used as a proxy of the number of guests eating lunch. Number of used plates was recorded from late August 2010 to early June 2020, i.e. covering the period both before and during the initial phase of the Covid-19 pandemic, so that making possible to evaluate changes in guest attendance during the pandemic. Since these were real data, all data elements pertaining to exact canteens or staff identity have been removed. There is a scarcity of real business data for scientific and educational purposes, so these datasets can play an important role in research and education within catering management, consumption pattern analysis, machine learning, data mining and other fields.", "doi": "10.1016/j.dib.2021.107138", "pmid": "34095385", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S2352-3409(21)00422-4"}, {"db": "pmc", "key": "PMC8165408"}], "notes": [], "created": "2021-06-08T08:56:05.493Z", "modified": "2022-11-22T05:46:23.879Z"}, {"entity": "publication", "iuid": "2ebb0a439bad48b093252fcb2a666c35", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ebb0a439bad48b093252fcb2a666c35.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ebb0a439bad48b093252fcb2a666c35"}}, "title": "Extracellular Vesicle Capture by AnTibody of CHoice and Enzymatic Release (EV-CATCHER): A customizable purification assay designed for small-RNA biomarker identification and evaluation of circulating small-EVs.", "authors": [{"family": "Mitchell", "given": "Megan I", "initials": "MI", "orcid": "0000-0002-1202-155X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a39353b6a1040bda4fc6ec41ce992cf.json"}}, {"family": "Ben-Dov", "given": "Iddo Z", "initials": "IZ"}, {"family": "Liu", "given": "Christina", "initials": "C"}, {"family": "Ye", "given": "Kenny", "initials": "K"}, {"family": "Chow", "given": "Kar", "initials": "K"}, {"family": "Kramer", "given": "Yael", "initials": "Y"}, {"family": "Gangadharan", "given": "Anju", "initials": "A"}, {"family": "Park", "given": "Steven", "initials": "S"}, {"family": "Fitzgerald", "given": "Sean", "initials": "S"}, {"family": "Ramnauth", "given": "Andrew", "initials": "A"}, {"family": "Perlin", "given": "David S", "initials": "DS"}, {"family": "Donato", "given": "Michele", "initials": "M"}, {"family": "Bhoy", "given": "Emily", "initials": "E"}, {"family": "Manouchehri Doulabi", "given": "Ehsan", "initials": "E"}, {"family": "Poulos", "given": "Michael", "initials": "M"}, {"family": "Kamali-Moghaddam", "given": "Masood", "initials": "M"}, {"family": "Loudig", "given": "Olivier", "initials": "O"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "J Extracell Vesicles", "issn": "2001-3078", "issn-l": null, "volume": "10", "issue": "8", "pages": "e12110"}, "abstract": "Circulating nucleic acids, encapsulated within small extracellular vesicles (EVs), provide a remote cellular snapshot of biomarkers derived from diseased tissues, however selective isolation is critical. Current laboratory-based purification techniques rely on the physical properties of small-EVs rather than their inherited cellular fingerprints. We established a highly-selective purification assay, termed EV-CATCHER, initially designed for high-throughput analysis of low-abundance small-RNA cargos by next-generation sequencing. We demonstrated its selectivity by specifically isolating and sequencing small-RNAs from mouse small-EVs spiked into human plasma. Western blotting, nanoparticle tracking, and transmission electron microscopy were used to validate and quantify the capture and release of intact small-EVs. As proof-of-principle for sensitive detection of circulating miRNAs, we compared small-RNA sequencing data from a subset of small-EVs serum-purified with EV-CATCHER to data from whole serum, using samples from a small cohort of recently hospitalized Covid-19 patients. We identified and validated, only in small-EVs, hsa-miR-146a and hsa-miR-126-3p to be significantly downregulated with disease severity. Separately, using convalescent sera from recovered Covid-19 patients with high anti-spike IgG titers, we confirmed the neutralizing properties, against SARS-CoV-2 in vitro, of a subset of small-EVs serum-purified by EV-CATCHER, as initially observed with ultracentrifuged small-EVs. Altogether our data highlight the sensitivity and versatility of EV-CATCHER.", "doi": "10.1002/jev2.12110", "pmid": "34122779", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8173589"}, {"db": "pii", "key": "JEV212110"}], "notes": [], "created": "2021-06-17T07:28:31.678Z", "modified": "2023-06-19T15:06:28.471Z"}, {"entity": "publication", "iuid": "3fea64a67cbe40219cc97c9ee830c67a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3fea64a67cbe40219cc97c9ee830c67a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3fea64a67cbe40219cc97c9ee830c67a"}}, "title": "Excess Mortality After COVID-19 in Swedish Long-Term Care Facilities", "authors": [{"family": "Ballin", "given": "Marcel", "initials": "M"}, {"family": "Bergman", "given": "Jonathan", "initials": "J"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Nordstr\u00f6m", "given": "Peter", "initials": "P"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "Journal of the American Medical Directors Association", "issn": "1525-8610", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/j.jamda.2021.06.010", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:08:23.850Z", "modified": "2021-07-14T09:13:47.733Z"}, {"entity": "publication", "iuid": "6e3d5779e96c4475b28d9954590d053a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e3d5779e96c4475b28d9954590d053a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e3d5779e96c4475b28d9954590d053a"}}, "title": "Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and territories in the Invasive Respiratory Infection Surveillance Initiative: a prospective analysis of surveillance data", "authors": [{"family": "Brueggemann", "given": "Angela B", "initials": "AB"}, {"family": "Jansen van Rensburg", "given": "Melissa J", "initials": "MJ"}, {"family": "Shaw", "given": "David", "initials": "D"}, {"family": "McCarthy", "given": "Noel D", "initials": "ND"}, {"family": "Jolley", "given": "Keith A", "initials": "KA"}, {"family": "Maiden", "given": "Martin C J", "initials": "MCJ"}, {"family": "van der Linden", "given": "Mark P G", "initials": "MPG"}, {"family": "Amin-Chowdhury", "given": "Zahin", "initials": "Z"}, {"family": "Bennett", "given": "D\u00e9sir\u00e9e E", "initials": "DE"}, {"family": "Borrow", "given": "Ray", "initials": "R"}, {"family": "Brandileone", "given": "Maria Cristina C", "initials": "MCC"}, {"family": "Broughton", "given": "Karen", "initials": "K"}, {"family": "Campbell", "given": "Ruth", "initials": "R"}, {"family": "Cao", "given": "Bin", "initials": "B"}, {"family": "Casanova", "given": "Carlo", "initials": "C"}, {"family": "Choi", "given": "Eun Hwa", "initials": "EH"}, {"family": "Chu", "given": "Yiu Wai", "initials": "YW"}, {"family": "Clark", "given": "Stephen A", "initials": "SA"}, {"family": "Claus", "given": "Heike", "initials": "H"}, {"family": "Coelho", "given": "Juliana", "initials": "J"}, {"family": "Corcoran", "given": "Mary", "initials": "M"}, {"family": "Cottrell", "given": "Simon", "initials": "S"}, {"family": "Cunney", "given": "Robert J", "initials": "RJ"}, {"family": "Dalby", "given": "Tine", "initials": "T"}, {"family": "Davies", "given": "Heather", "initials": "H"}, {"family": "de Gouveia", "given": "Linda", "initials": "L"}, {"family": "Deghmane", "given": "Ala Eddine", "initials": "AE"}, {"family": "Demczuk", "given": "Walter", "initials": "W"}, {"family": "Desmet", "given": "Stefanie", "initials": "S"}, {"family": "Drew", "given": "Richard J", "initials": "RJ"}, {"family": "du Plessis", "given": "Mignon", "initials": "M"}, {"family": "Erlendsdottir", "given": "Helga", "initials": "H"}, {"family": "Fry", "given": "Norman K", "initials": "NK"}, {"family": "Fuursted", "given": "Kurt", "initials": "K"}, {"family": "Gray", "given": "Steve J", "initials": "SJ"}, {"family": "Henriques-Normark", "given": "Birgitta", "initials": "B"}, {"family": "Hale", "given": "Thomas", "initials": "T"}, {"family": "Hilty", "given": "Markus", "initials": "M"}, {"family": "Hoffmann", "given": "Steen", "initials": "S"}, {"family": "Humphreys", "given": "Hilary", "initials": "H"}, {"family": "Ip", "given": "Margaret", "initials": "M"}, {"family": "Jacobsson", "given": "Susanne", "initials": "S"}, {"family": "Johnston", "given": "Jillian", "initials": "J"}, {"family": "Kozakova", "given": "Jana", "initials": "J"}, {"family": "Kristinsson", "given": "Karl G", "initials": "KG"}, {"family": "Krizova", "given": "Pavla", "initials": "P"}, {"family": "Kuch", "given": "Alicja", "initials": "A"}, {"family": "Ladhani", "given": "Shamez N", "initials": "SN"}, {"family": "L\u00e2m", "given": "Thi\u00ean Tr\u00ed", "initials": "TT"}, {"family": "Lebedova", "given": "Vera", "initials": "V"}, {"family": "Lindholm", "given": "Laura", "initials": "L"}, {"family": "Litt", "given": "David J", "initials": "DJ"}, {"family": "Martin", "given": "Irene", "initials": "I"}, {"family": "Martiny", "given": "Delphine", "initials": "D"}, {"family": "Mattheus", "given": "Wesley", "initials": "W"}, {"family": "McElligott", "given": "Martha", "initials": "M"}, {"family": "Meehan", "given": "Mary", "initials": "M"}, {"family": "Meiring", "given": "Susan", "initials": "S"}, {"family": "M\u00f6lling", "given": "Paula", "initials": "P"}, {"family": "Morfeldt", "given": "Eva", "initials": "E"}, {"family": "Morgan", "given": "Julie", "initials": "J"}, {"family": "Mulhall", "given": "Robert M", "initials": "RM"}, {"family": "Mu\u00f1oz-Almagro", "given": "Carmen", "initials": "C"}, {"family": "Murdoch", "given": "David R", "initials": "DR"}, {"family": "Murphy", "given": "Joy", "initials": "J"}, {"family": "Musilek", "given": "Martin", "initials": "M"}, {"family": "Mzabi", "given": "Alexandre", "initials": "A"}, {"family": "Perez-Arg\u00fcello", "given": "Amaresh", "initials": "A"}, {"family": "Perrin", "given": "Monique", "initials": "M"}, {"family": "Perry", "given": "Malorie", "initials": "M"}, {"family": "Redin", "given": "Alba", "initials": "A"}, {"family": "Roberts", "given": "Richard", "initials": "R"}, {"family": "Roberts", "given": "Maria", "initials": "M"}, {"family": "Rokney", "given": "Assaf", "initials": "A"}, {"family": "Ron", "given": "Merav", "initials": "M"}, {"family": "Scott", "given": "Kevin J", "initials": "KJ"}, {"family": "Sheppard", "given": "Carmen L", "initials": "CL"}, {"family": "Siira", "given": "Lotta", "initials": "L"}, {"family": "Skoczy\u0144ska", "given": "Anna", "initials": "A"}, {"family": "Sloan", "given": "Monica", "initials": "M"}, {"family": "Slotved", "given": "Hans Christian", "initials": "HC"}, {"family": "Smith", "given": "Andrew J", "initials": "AJ"}, {"family": "Song", "given": "Joon Young", "initials": "JY"}, {"family": "Taha", "given": "Muhamed Kheir", "initials": "MK"}, {"family": "Toropainen", "given": "Maija", "initials": "M"}, {"family": "Tsang", "given": "Dominic", "initials": "D"}, {"family": "Vainio", "given": "Anni", "initials": "A"}, {"family": "van Sorge", "given": "Nina M", "initials": "NM"}, {"family": "Varon", "given": "Emmanuelle", "initials": "E"}, {"family": "Vlach", "given": "Jiri", "initials": "J"}, {"family": "Vogel", "given": "Ulrich", "initials": "U"}, {"family": "Vohrnova", "given": "Sandra", "initials": "S"}, {"family": "von Gottberg", "given": "Anne", "initials": "A"}, {"family": "Zanella", "given": "Rosemeire C", "initials": "RC"}, {"family": "Zhou", "given": "Fei", "initials": "F"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "The Lancet Digital Health", "issn": "2589-7500", "issn-l": null, "volume": "3", "issue": "6", "pages": "e360-e370"}, "abstract": "Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis, which are typically transmitted via respiratory droplets, are leading causes of invasive diseases, including bacteraemic pneumonia and meningitis, and of secondary infections subsequent to post-viral respiratory disease. The aim of this study was to investigate the incidence of invasive disease due to these pathogens during the early months of the COVID-19 pandemic.\r\n\r\nIn this prospective analysis of surveillance data, laboratories in 26 countries and territories across six continents submitted data on cases of invasive disease due to S pneumoniae, H influenzae, and N meningitidis from Jan 1, 2018, to May, 31, 2020, as part of the Invasive Respiratory Infection Surveillance (IRIS) Initiative. Numbers of weekly cases in 2020 were compared with corresponding data for 2018 and 2019. Data for invasive disease due to Streptococcus agalactiae, a non-respiratory pathogen, were collected from nine laboratories for comparison. The stringency of COVID-19 containment measures was quantified using the Oxford COVID-19 Government Response Tracker. Changes in population movements were assessed using Google COVID-19 Community Mobility Reports. Interrupted time-series modelling quantified changes in the incidence of invasive disease due to S pneumoniae, H influenzae, and N meningitidis in 2020 relative to when containment measures were imposed.\r\n\r\n27 laboratories from 26 countries and territories submitted data to the IRIS Initiative for S pneumoniae (62 837 total cases), 24 laboratories from 24 countries submitted data for H influenzae (7796 total cases), and 21 laboratories from 21 countries submitted data for N meningitidis (5877 total cases). All countries and territories had experienced a significant and sustained reduction in invasive diseases due to S pneumoniae, H influenzae, and N meningitidis in early 2020 (Jan 1 to May 31, 2020), coinciding with the introduction of COVID-19 containment measures in each country. By contrast, no significant changes in the incidence of invasive S agalactiae infections were observed. Similar trends were observed across most countries and territories despite differing stringency in COVID-19 control policies. The incidence of reported S pneumoniae infections decreased by 68% at 4 weeks (incidence rate ratio 0\u00b732 [95% CI 0\u00b727-0\u00b737]) and 82% at 8 weeks (0\u00b718 [0\u00b714-0\u00b723]) following the week in which significant changes in population movements were recorded.\r\n\r\nThe introduction of COVID-19 containment policies and public information campaigns likely reduced transmission of S pneumoniae, H influenzae, and N meningitidis, leading to a significant reduction in life-threatening invasive diseases in many countries worldwide.\r\n\r\nWellcome Trust (UK), Robert Koch Institute (Germany), Federal Ministry of Health (Germany), Pfizer, Merck, Health Protection Surveillance Centre (Ireland), SpID-Net project (Ireland), European Centre for Disease Prevention and Control (European Union), Horizon 2020 (European Commission), Ministry of Health (Poland), National Programme of Antibiotic Protection (Poland), Ministry of Science and Higher Education (Poland), Agencia de Salut P\u00fablica de Catalunya (Spain), Sant Joan de Deu Foundation (Spain), Knut and Alice Wallenberg Foundation (Sweden), Swedish Research Council (Sweden), Region Stockholm (Sweden), Federal Office of Public Health of Switzerland (Switzerland), and French Public Health Agency (France).", "doi": "10.1016/s2589-7500(21)00077-7", "pmid": "34045002", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2589-7500(21)00077-7"}, {"db": "URL", "key": "https://github.com/brueggemann-lab/iris-ldh-2020/tree/main/code", "description": "Data processing, visualisation, analysis code"}], "notes": [], "created": "2021-05-29T15:25:23.212Z", "modified": "2021-12-22T12:47:24.255Z"}, {"entity": "publication", "iuid": "6a107e18fba94c87bfcf92e94c907307", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a107e18fba94c87bfcf92e94c907307.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a107e18fba94c87bfcf92e94c907307"}}, "title": "Cardiovascular-related deaths at the beginning of the COVID-19 outbreak: a prospective analysis based on the UK Biobank", "authors": [{"family": "Wang", "given": "Junren", "initials": "J"}, {"family": "Zhu", "given": "Jianwei", "initials": "J"}, {"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Sun", "given": "Yajing", "initials": "Y"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "Qu", "given": "Yuanyuan", "initials": "Y"}, {"family": "Valdimarsdottir", "given": "Unnur", "initials": "U"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "6", "pages": "e046931"}, "abstract": null, "doi": "10.1136/bmjopen-2020-046931", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-08T08:44:53.007Z", "modified": "2021-06-08T08:45:06.122Z"}, {"entity": "publication", "iuid": "882b84f8d9014804bb645ecafcfd3ced", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/882b84f8d9014804bb645ecafcfd3ced.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/882b84f8d9014804bb645ecafcfd3ced"}}, "title": "COVID-19 in immunocompromised populations: implications for prognosis and repurposing of immunotherapies.", "authors": [{"family": "Goldman", "given": "Jason D", "initials": "JD", "orcid": "0000-0002-3825-6832", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87e08520608949ac9fa338a38550098b.json"}}, {"family": "Robinson", "given": "Philip C", "initials": "PC", "orcid": "0000-0002-3156-3418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/950b622d31724172817ccde09902d215.json"}}, {"family": "Uldrick", "given": "Thomas S", "initials": "TS", "orcid": "0000-0001-6959-0924", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69d5a4f766394718943dea6300513856.json"}}, {"family": "Ljungman", "given": "Per", "initials": "P", "orcid": "0000-0002-8281-3245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d4546eb504184683ab712eee858ea9cb.json"}}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "J Immunother Cancer", "issn": "2051-1426", "volume": "9", "issue": "6", "issn-l": null}, "abstract": "SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. COVID-19 has highly variable disease severity and a bimodal course characterized by acute respiratory viral infection followed by hyperinflammation in a subset of patients with severe disease. This immune dysregulation is characterized by lymphocytopenia, elevated levels of plasma cytokines and proliferative and exhausted T cells, among other dysfunctional cell types. Immunocompromised persons often fare worse in the context of acute respiratory infections, but preliminary data suggest this may not hold true for COVID-19. In this review, we explore the effect of SARS-CoV-2 infection on mortality in four populations with distinct forms of immunocompromise: (1) persons with hematological malignancies (HM) and hematopoietic stem cell transplant (HCT) recipients; (2) solid organ transplant recipients (SOTRs); (3) persons with rheumatological diseases; and (4) persons living with HIV (PLWH). For each population, key immunological defects are described and how these relate to the immune dysregulation in COVID-19. Next, outcomes including mortality after SARS-CoV-2 infection are described for each population, giving comparisons to the general population of age-matched and comorbidity-matched controls. In these four populations, iatrogenic or disease-related immunosuppression is not clearly associated with poor prognosis in HM, HCT, SOTR, rheumatological diseases, or HIV. However, certain individual immunosuppressants or disease states may be associated with harmful or beneficial effects, including harm from severe CD4 lymphocytopenia in PLWH and possible benefit to the calcineurin inhibitor ciclosporin in SOTRs, or tumor necrosis factor-\u03b1 inhibitors in persons with rheumatic diseases. Lastly, insights gained from clinical and translational studies are explored as to the relevance for repurposing of immunosuppressive host-directed therapies for the treatment of hyperinflammation in COVID-19 in the general population.", "doi": "10.1136/jitc-2021-002630", "pmid": "34117116", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jitc-2021-002630"}], "notes": [], "created": "2021-06-14T06:33:51.825Z", "modified": "2021-06-14T06:33:53.045Z"}, {"entity": "publication", "iuid": "020205cca7b44ead9df18e321fb13dd1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/020205cca7b44ead9df18e321fb13dd1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/020205cca7b44ead9df18e321fb13dd1"}}, "title": "Autoimmune Encephalitis Presenting With Malignant Catatonia in a 40-Year-Old Male Patient With COVID-19.", "authors": [{"family": "Mulder", "given": "Jan", "initials": "J"}, {"family": "Feresiadou", "given": "Amalia", "initials": "A"}, {"family": "F\u00e4llmar", "given": "David", "initials": "D"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "Rasmusson", "given": "Annica", "initials": "A"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Cunningham", "given": "Janet L", "initials": "JL"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Am J Psychiatry", "issn": "1535-7228", "volume": "178", "issue": "6", "pages": "485-489", "issn-l": null}, "abstract": null, "doi": "10.1176/appi.ajp.2020.20081236", "pmid": "34154381", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:23:09.280Z", "modified": "2021-06-28T18:23:09.306Z"}, {"entity": "publication", "iuid": "228ce5c33a6e43868dc6d99a1b519861", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/228ce5c33a6e43868dc6d99a1b519861.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/228ce5c33a6e43868dc6d99a1b519861"}}, "title": "Author Correction: Attributes and predictors of long COVID.", "authors": [{"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Murray", "given": "Benjamin", "initials": "B", "orcid": "0000-0002-2413-923X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebec738df0224bf4874fd6c08fd23fae.json"}}, {"family": "Varsavsky", "given": "Thomas", "initials": "T"}, {"family": "Graham", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-4170-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f5f4e19812a46ed9e873732ec25e28d.json"}}, {"family": "Penfold", "given": "Rose S", "initials": "RS"}, {"family": "Bowyer", "given": "Ruth C", "initials": "RC", "orcid": "0000-0002-6941-8160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eebaf361c184499ca6729aa60cc0af3d.json"}}, {"family": "Pujol", "given": "Joan Capdevila", "initials": "JC", "orcid": "0000-0003-1658-1076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60965a027a4b4d048728748f09c98594.json"}}, {"family": "Klaser", "given": "Kerstin", "initials": "K"}, {"family": "Antonelli", "given": "Michela", "initials": "M"}, {"family": "Canas", "given": "Liane S", "initials": "LS"}, {"family": "Molteni", "given": "Erika", "initials": "E", "orcid": "0000-0001-7773-8140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9aed1fbe444b48d4bfacb12050953c8e.json"}}, {"family": "Modat", "given": "Marc", "initials": "M"}, {"family": "Jorge Cardoso", "given": "M", "initials": "M", "orcid": "0000-0003-1284-2558", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0ed3abec67644e186650e1d1dcbbe0b.json"}}, {"family": "May", "given": "Anna", "initials": "A"}, {"family": "Ganesh", "given": "Sajaysurya", "initials": "S", "orcid": "0000-0002-3720-4176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6dbf91180806442082ce6732c1b75923.json"}}, {"family": "Davies", "given": "Richard", "initials": "R", "orcid": "0000-0003-2050-3994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b82cc92615f462d9af0153a6fb94fde.json"}}, {"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Drew", "given": "David A", "initials": "DA", "orcid": "0000-0002-8813-0816", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd3a2cffdc104f18b8684cf4f27d68b2.json"}}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Merino", "given": "Jordi", "initials": "J", "orcid": "0000-0001-8312-1438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12ab049914a542b39affcfb4196861d2.json"}}, {"family": "Tsereteli", "given": "Neli", "initials": "N"}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f34c0d3602439abe6096293c7c732d.json"}}, {"family": "Gomez", "given": "Maria F", "initials": "MF", "orcid": "0000-0001-6210-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e09e37219c4f42c8a7b3a982da523859.json"}}, {"family": "Duncan", "given": "Emma L", "initials": "EL"}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874802ae65824a90ba50eabdeabb8356.json"}}, {"family": "Williams", "given": "Frances M K", "initials": "FMK", "orcid": "0000-0002-2998-2744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87a6db988c2e421f81fce7773436aefa.json"}}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74cf1f7094744ee289fa5df041e7cb5b.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-7284-6767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeefbf47fd384d5390109fe1a903bd18.json"}}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Ourselin", "given": "Sebastien", "initials": "S", "orcid": "0000-0002-5694-5340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74c7b9b1633144879042d198c7205656.json"}}, {"family": "Spector", "given": "Tim", "initials": "T", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}], "type": "published erratum", "published": "2021-06-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956", "volume": "27", "issue": "6", "pages": "1116"}, "abstract": null, "doi": "10.1038/s41591-021-01361-2", "pmid": "34045738", "labels": {"Type: Other": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-021-01361-2"}], "notes": [], "created": "2021-05-29T15:23:39.445Z", "modified": "2023-06-19T15:28:16.046Z"}, {"entity": "publication", "iuid": "95a6e8fb6e3047ffad0f3a0583b05a01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95a6e8fb6e3047ffad0f3a0583b05a01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95a6e8fb6e3047ffad0f3a0583b05a01"}}, "title": "Association Between Collagenous and Lymphocytic Colitis and Risk of Severe Coronavirus Disease 2019", "authors": [{"family": "Khalili", "given": "Hamed", "initials": "H", "orcid": "0000-0002-7956-6941", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e248e3e76594014af041c8e62cfcfc6.json"}}, {"family": "Zheng", "given": "Tenghao", "initials": "T"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Larsson", "given": "Emma", "initials": "E"}, {"family": "Munch", "given": "Andreas", "initials": "A"}, {"family": "Sjoberg", "given": "Klas", "initials": "K"}, {"family": "Almer", "given": "Sven", "initials": "S"}, {"family": "Vigren", "given": "Lina", "initials": "L"}, {"family": "Janczewska", "given": "Izabella", "initials": "I"}, {"family": "Ohlsson", "given": "Bodil", "initials": "B"}, {"family": "Bresso", "given": "Francesca", "initials": "F"}, {"family": "Mellander", "given": "Maire Rose", "initials": "MR"}, {"family": "Ol\u00e9n", "given": "Ola", "initials": "O"}, {"family": "Roelstraete", "given": "Bjorn", "initials": "B"}, {"family": "Franke", "given": "Andre", "initials": "A"}, {"family": "Simon", "given": "Tracey G", "initials": "TG"}, {"family": "D'Amato", "given": "Mauro", "initials": "M"}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "Gastroenterology", "issn": "1528-0012", "issn-l": null, "volume": "160", "issue": "7", "pages": "2585-2587.e3"}, "abstract": null, "doi": "10.1053/j.gastro.2021.02.029", "pmid": "33610527", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0016-5085(21)00417-0"}], "notes": [], "created": "2021-02-22T11:50:13.123Z", "modified": "2021-06-18T12:17:26.842Z"}, {"entity": "publication", "iuid": "e9633a955a014394a5c1b34238b492cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e9633a955a014394a5c1b34238b492cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e9633a955a014394a5c1b34238b492cf"}}, "title": "Are in-person scientific conferences dead or alive?", "authors": [{"family": "Dua", "given": "Nick", "initials": "N"}, {"family": "Fyrenius", "given": "Mattias", "initials": "M"}, {"family": "Johnson", "given": "Deborah L", "initials": "DL"}, {"family": "Moos", "given": "Walter H", "initials": "WH", "orcid": "0000-0001-7244-811X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc7341bafa42423e8d16afd76b97ed64.json"}}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "FASEB Bioadv", "issn": "2573-9832", "volume": "3", "issue": "6", "pages": "420-427", "issn-l": null}, "abstract": "Given the disruption caused by the COVID-19 pandemic, life as we knew it has been turned upside down, but the need for science to go on has never been stronger. In the realm of scientific conferences, with the requirement for social distancing, the importance of wearing face coverings, and travel restrictions, only virtual meetings have been possible during the pandemic. But many are asking: What is the new post-pandemic normal likely to be? Do we still want to have in-person meetings when the restrictions are eased? Assuming we do, when will they be possible again, and under what conditions? Regardless of what the benefits of virtual symposia might be, are they here to stay? These questions, and many more that are being asked around the world today, are the subject of this perspective. Herein, we attempt to provide useful context and insight into where scientific meetings have been, where they are today, where they are going, and how they will get there. Our conclusion is that the pandemic has created an accelerated opportunity to make the world of future scientific conferences better in a \"both/and\" collaborative in-person/virtual scenario, not the more limited \"pick one\" choice.", "doi": "10.1096/fba.2020-00139", "pmid": "34124597", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "FBA21205"}, {"db": "pmc", "key": "PMC8171307"}], "notes": [], "created": "2021-06-17T07:40:58.715Z", "modified": "2021-06-17T07:40:58.766Z"}, {"entity": "publication", "iuid": "0cc8de28a8744ab880da9073a0059bab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0cc8de28a8744ab880da9073a0059bab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0cc8de28a8744ab880da9073a0059bab"}}, "title": "Antimicrobial resistance research in a post-pandemic world: Insights on antimicrobial resistance research in the COVID-19 pandemic", "authors": [{"family": "Rodr\u00edguez-Ba\u00f1o", "given": "Jes\u00fas", "initials": "J"}, {"family": "Rossolini", "given": "Gian Maria", "initials": "GM"}, {"family": "Schultsz", "given": "Constance", "initials": "C"}, {"family": "Tacconelli", "given": "Evelina", "initials": "E"}, {"family": "Murthy", "given": "Srinivas", "initials": "S"}, {"family": "Ohmagari", "given": "Norio", "initials": "N"}, {"family": "Holmes", "given": "Alison", "initials": "A"}, {"family": "Bachmann", "given": "Till", "initials": "T"}, {"family": "Goossens", "given": "Herman", "initials": "H"}, {"family": "Canton", "given": "Rafael", "initials": "R"}, {"family": "Roberts", "given": "Adam P", "initials": "AP"}, {"family": "Henriques-Normark", "given": "Birgitta", "initials": "B"}, {"family": "Clancy", "given": "Cornelius J", "initials": "CJ"}, {"family": "Huttner", "given": "Benedikt", "initials": "B"}, {"family": "Fagerstedt", "given": "Patriq", "initials": "P"}, {"family": "Lahiri", "given": "Shawon", "initials": "S"}, {"family": "Kaushic", "given": "Charu", "initials": "C"}, {"family": "Hoffman", "given": "Steven J", "initials": "SJ"}, {"family": "Warren", "given": "Margo", "initials": "M"}, {"family": "Zoubiane", "given": "Ghada", "initials": "G"}, {"family": "Essack", "given": "Sabiha", "initials": "S"}, {"family": "Laxminarayan", "given": "Ramanan", "initials": "R"}, {"family": "Plant", "given": "Laura", "initials": "L"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "Journal of Global Antimicrobial Resistance", "issn": "2213-7165", "volume": "25", "issue": null, "pages": "5-7", "issn-l": null}, "abstract": "Antimicrobial resistance must be recognised as a global societal priority - even in the face of the worldwide challenge of the COVID-19 pandemic. COVID-19 has illustrated the vulnerability of our healthcare systems in co-managing multiple infectious disease threats as resources for monitoring and detecting, and conducting research on antimicrobial resistance have been compromised during the pandemic. The increased awareness of the importance of infectious diseases, clinical microbiology and infection control and lessons learnt during the COVID-19 pandemic should be exploited to ensure that emergence of future infectious disease threats, including those related to AMR, are minimised. Harnessing the public understanding of the relevance of infectious diseases towards the long-term pandemic of AMR could have major implications for promoting good practices about the control of AMR transmission.", "doi": "10.1016/j.jgar.2021.02.013", "pmid": "33662647", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-7165(21)00045-X"}, {"db": "pmc", "key": "PMC7919515"}], "notes": [], "created": "2021-03-06T10:20:21.390Z", "modified": "2021-12-22T12:47:00.874Z"}, {"entity": "publication", "iuid": "9b8650bb534049239347a549570038aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b8650bb534049239347a549570038aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b8650bb534049239347a549570038aa"}}, "title": "A unique view of SARS-COV-2 through the lens of ORF8 protein", "authors": [{"family": "Hassan", "given": "Sk Sarif", "initials": "SS"}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA"}, {"family": "Panda", "given": "Pritam Kumar", "initials": "PK"}, {"family": "Ghosh", "given": "Shinjini", "initials": "S"}, {"family": "Attrish", "given": "Diksha", "initials": "D"}, {"family": "Choudhury", "given": "Pabitra Pal", "initials": "PP"}, {"family": "Seyran", "given": "Murat", "initials": "M"}, {"family": "Pizzol", "given": "Damiano", "initials": "D"}, {"family": "Adadi", "given": "Parise", "initials": "P"}, {"family": "Abd El-Aziz", "given": "Tarek Mohamed", "initials": "TM"}, {"family": "Soares", "given": "Antonio", "initials": "A"}, {"family": "Kandimalla", "given": "Ramesh", "initials": "R"}, {"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Lal", "given": "Amos", "initials": "A"}, {"family": "Azad", "given": "Gajendra Kumar", "initials": "GK"}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN"}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Baetas-da-Cruz", "given": "Wagner", "initials": "W"}, {"family": "Uhal", "given": "Bruce D", "initials": "BD"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Chauhan", "given": "Gaurav", "initials": "G"}, {"family": "Barh", "given": "Debmalya", "initials": "D"}, {"family": "Redwan", "given": "Elrashdy M", "initials": "EM"}, {"family": "Dayhoff", "given": "Guy W", "initials": "GW"}, {"family": "Bazan", "given": "Nicolas G", "initials": "NG"}, {"family": "Serrano-Aroca", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "El-Demerdash", "given": "Amr", "initials": "A"}, {"family": "Mishra", "given": "Yogendra K", "initials": "YK"}, {"family": "Palu", "given": "Giorgio", "initials": "G"}, {"family": "Takayama", "given": "Kazuo", "initials": "K"}, {"family": "Brufsky", "given": "Adam M", "initials": "AM"}, {"family": "Tambuwala", "given": "Murtaza M", "initials": "MM"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "Computers in Biology and Medicine", "issn": "0010-4825", "issn-l": null, "volume": "133", "issue": null, "pages": "104380"}, "abstract": null, "doi": "10.1016/j.compbiomed.2021.104380", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-20T17:50:03.288Z", "modified": "2021-06-30T05:18:19.633Z"}, {"entity": "publication", "iuid": "76c6675ecd144263b48025aceb887ab0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76c6675ecd144263b48025aceb887ab0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76c6675ecd144263b48025aceb887ab0"}}, "title": "A collection of the novel coronavirus (COVID-19) detection assays, issues, and challenges.", "authors": [{"family": "Rezvani Ghomi", "given": "Erfan", "initials": "E"}, {"family": "Khosravi", "given": "Fatemeh", "initials": "F"}, {"family": "Mohseni-M", "given": "Ali", "initials": "A"}, {"family": "Nourbakhsh", "given": "Nooshin", "initials": "N"}, {"family": "Haji Mohammad Hoseini", "given": "Mahsa", "initials": "M"}, {"family": "Singh", "given": "Sunpreet", "initials": "S"}, {"family": "Hedenqvist", "given": "Mikael S", "initials": "MS"}, {"family": "Ramakrishna", "given": "Seeram", "initials": "S"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "issn-l": null, "volume": "7", "issue": "6", "pages": "e07247"}, "abstract": "The global pandemic of COVID-19 has rapidly increased the number of infected cases as well as asymptomatic individuals in many, if not all the societies around the world. This issue increases the demand for accurate and rapid detection of SARS-CoV-2. While accurate and rapid detection is critical for diagnosing SARS-CoV-2, the appropriate course of treatment must be chosen to help patients and prevent its further spread. Testing platform accuracy with high sensitivity and specificity for SARS-CoV-2 is equally important for clinical, regional, and global arenas to mitigate secondary transmission rounds. The objective of this article is to compare the current detection technology and introduce the most accurate and rapid ones that are suitable for pandemic circumstances. Hence, the importance of rapid detection in societies is discussed initially. Following this, the current technology for rapid detection of SARS-CoV-2 is explained and classified into three different categories: nucleic acid-based, protein-based, and point of care (PoC) detection testing. Then, the current issues for diagnostic procedures in laboratories are discussed. Finally, the role of new technologies in countering COVID-19 is also introduced to assist researchers in the development of accurate and timely detection of coronaviruses. As coronavirus continues to affect human lives in a detrimental manner, the development of rapid and accurate virus detection methods could promote COVID-19 diagnosis accessible to both individuals and the mass population at patient care. In this regard, rRT-PCR and multiplex RT-PCR detection techniques hold promise.", "doi": "10.1016/j.heliyon.2021.e07247", "pmid": "34124407", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)01350-5"}, {"db": "pmc", "key": "PMC8179727"}], "notes": [], "created": "2021-06-17T07:31:39.185Z", "modified": "2021-06-17T07:31:53.661Z"}, {"entity": "publication", "iuid": "f6daf7ba0a6245ef80f67745d470754a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6daf7ba0a6245ef80f67745d470754a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6daf7ba0a6245ef80f67745d470754a"}}, "title": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process", "authors": [{"family": "Noske", "given": "G D", "initials": "GD"}, {"family": "Nakamura", "given": "A M", "initials": "AM"}, {"family": "Gawriljuk", "given": "V O", "initials": "VO"}, {"family": "Fernandes", "given": "R S", "initials": "RS"}, {"family": "M. A. Lima", "given": "G", "initials": "G"}, {"family": "V. D. Rosa", "given": "H", "initials": "H"}, {"family": "Pereira", "given": "H D", "initials": "HD"}, {"family": "C. M. Zeri", "given": "A", "initials": "A"}, {"family": "A. F. Z. Nascimento", "given": "A", "initials": "A"}, {"family": "C. L. C. Freire", "given": "M", "initials": "M"}, {"family": "Fearon", "given": "D", "initials": "D"}, {"family": "Douangamath", "given": "A", "initials": "A"}, {"family": "von Delft", "given": "F", "initials": "F"}, {"family": "Oliva", "given": "G", "initials": "G"}, {"family": "Godoy", "given": "A S", "initials": "AS"}], "type": "journal-article", "published": "2021-06-00", "journal": {"title": "Journal of Molecular Biology", "issn": "0022-2836", "pages": "167118", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jmb.2021.167118", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "PDB", "key": "7KFI", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7MBG,", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7KPH", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7N6N", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7LFE", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7LDX", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7LFP", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7KVL", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7N5Z", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}, {"db": "PDB", "key": "7KVR", "description": "A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process - Structure factors and atomic coordinates"}], "notes": [], "created": "2021-06-28T18:07:33.728Z", "modified": "2021-11-18T13:25:03.256Z"}, {"entity": "publication", "iuid": "31a3255454da4e6e98b7717709f33eca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/31a3255454da4e6e98b7717709f33eca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/31a3255454da4e6e98b7717709f33eca"}}, "title": "Political stigma of communicable diseases in complex emergencies.", "authors": [{"family": "Bellizzi", "given": "Saverio", "initials": "S"}, {"family": "Bassat", "given": "Quique", "initials": "Q"}, {"family": "Pichierri", "given": "Giuseppe", "initials": "G"}, {"family": "Cegolon", "given": "Luca", "initials": "L"}, {"family": "Panu Napodano", "given": "Catello Mario", "initials": "CM"}, {"family": "Farina", "given": "Gabriele", "initials": "G"}, {"family": "Murgia", "given": "Paola", "initials": "P"}, {"family": "Ali Maher", "given": "Osama", "initials": "O"}], "type": "journal article", "published": "2021-05-31", "journal": {"title": "J Infect Dev Ctries", "issn": "1972-2680", "volume": "15", "issue": "5", "pages": "747-748", "issn-l": null}, "abstract": null, "doi": "10.3855/jidc.14056", "pmid": "34106901", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-06-10T10:14:27.899Z", "modified": "2021-06-10T10:14:27.909Z"}, {"entity": "publication", "iuid": "81ad5751a2ab4d1d982c75035dc761e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/81ad5751a2ab4d1d982c75035dc761e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/81ad5751a2ab4d1d982c75035dc761e2"}}, "title": "More green, less lonely? A longitudinal cohort study.", "authors": [{"family": "Astell-Burt", "given": "Thomas", "initials": "T"}, {"family": "Hartig", "given": "Terry", "initials": "T"}, {"family": "Eckermann", "given": "Simon", "initials": "S"}, {"family": "Nieuwenhuijsen", "given": "Mark", "initials": "M"}, {"family": "McMunn", "given": "Anne", "initials": "A"}, {"family": "Frumkin", "given": "Howard", "initials": "H"}, {"family": "Feng", "given": "Xiaoqi", "initials": "X"}], "type": "journal article", "published": "2021-05-31", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "issn-l": "0300-5771", "volume": null, "issue": null, "pages": null}, "abstract": "Urban greening may reduce loneliness by offering opportunities for solace, social reconnection and supporting processes such as stress relief. We (i) assessed associations between residential green space and cumulative incidence of, and relief from, loneliness over 4 years; and (ii) explored contingencies by age, sex, disability and cohabitation status.\r\n\r\nMultilevel logistic regressions of change in loneliness status in 8049 city-dwellers between 2013 (baseline) and 2017 (follow-up) in the Household, Income and Labour Dynamics in Australia study. Associations with objectively measured discrete green-space buffers (e.g. parks) (<400, <800 and <1600 m) were adjusted for age, sex, disability, cohabitation status, children and socio-economic variables. Results were translated into absolute risk reductions in loneliness per 10% increase in urban greening.\r\n\r\nThe absolute risk of loneliness rose from 15.9% to 16.9% over the 4 years; however, a 10% increase in urban greening within 1.6 km was associated with lower cumulative incident loneliness [odds ratio (OR) = 0.927, 95% confidence interval (CI) = 0.862 to 0.996; absolute risk reduction = 0.66%]. Stronger association was observed for people living alone (OR = 0.828, 95% CI = 0.725 to 0.944). In comparison to people with <10% green space, the ORs for cumulative incident loneliness were 0.833 (95% CI = 0.695 to 0.997), 0.790 (95% CI = 0.624 to 1.000) and 0.736 (95% CI = 0.549 to 0.986) for 10-20%, 20-30% and >30% green space, respectively. Compared with the <10% green-space reference group with 13.78% incident loneliness over 4 years and conservatively assuming no impact on incident loneliness, associations translated into absolute risk reductions of 1.70%, 2.26% and 2.72% within populations with 10-20%, 20-30% and >30% green space, respectively. These associations were stronger again for people living alone, with 10-20% (OR = 0.608, 95% CI = 0.448 to 0.826), 20-30% (OR = 0.649, 95% CI = 0.436 to 0.966) and >30% (OR = 0.480, 95% CI = 0.278 to 0.829) green space within 1600 m. No age, sex or disability-related contingencies, associations with green space within 400 or 800 m or relief from loneliness reported at baseline were observed.\r\n\r\nA lower cumulative incidence of loneliness was observed among people with more green space within 1600 m of home, especially for people living alone. Potential biopsychosocial mechanisms warrant investigation.", "doi": "10.1093/ije/dyab089", "pmid": "34057994", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "6289969"}], "notes": [], "created": "2021-06-04T11:24:52.062Z", "modified": "2022-11-23T09:00:05.599Z"}, {"entity": "publication", "iuid": "db2bc2a48698482fac8899fdac4646d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db2bc2a48698482fac8899fdac4646d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db2bc2a48698482fac8899fdac4646d5"}}, "title": "Evaluation of Production Lots of a Rapid Point-of-Care Lateral Flow Serological Test Intended for Identification of IgM and IgG against the N-Terminal Part of the Spike Protein (S1) of SARS-CoV-2.", "authors": [{"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Kolstad", "given": "Linda", "initials": "L"}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "journal article", "published": "2021-05-31", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "13", "issue": "6", "pages": null}, "abstract": "The potential of rapid point-of-care (POC) tests has been subject of doubt due to an eventual risk of production errors. The aim was therefore to evaluate the two separate production lots of a commercial POC lateral flow test, intended for the detection of IgM and IgG against the SARS-CoV-2 spike protein (S1). Control samples consisted of serum from individuals with confirmed SARS-CoV-2 infection and pre-COVID-19 negative sera gathered from a biobank. The presence of anti-S1 IgM/IgG in the sera was verified by an in-house Luminex-based serological assay (COVID-19 SIA). One hundred samples were verified as positive for anti-S1 IgG and 74 for anti-S1 IgM. Two hundred samples were verified as negative for anti-S1 IgM/IgG. For the two lots of the POC-test, the sensitivities were 93.2% and 87.8% for IgM and 93.0% and 100% for IgG. The specificities were 100% for IgM and 99.5% for IgG. The positive predictive value was 100% for IgM and 98.9% and 99.0% for IgG. The negative predictive value was 97.6% and 95.7% for IgM, and 96.6% and 100% for IgG. The evaluated POC-test is suitable to assess anti-SARS-CoV-2 S1 IgM and IgG, as a measure of previous virus exposure on an individual level. The external validation of separate lots of rapid POC-tests is encouraged to ensure high sensitivity before market introduction.", "doi": "10.3390/v13061043", "pmid": "34072890", "labels": {"Type: Journal article": null, "Funder: H2020": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Category: Health": null, "Research Area: High-throughput and high-content serology": null}, "xrefs": [{"db": "pii", "key": "v13061043"}], "notes": [], "created": "2021-06-04T11:16:38.767Z", "modified": "2021-08-25T08:16:14.306Z"}, {"entity": "publication", "iuid": "392c272d9fdc407b9613f69a4a167c9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/392c272d9fdc407b9613f69a4a167c9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/392c272d9fdc407b9613f69a4a167c9c"}}, "title": "Implementing Public Health Strategies-The Need for Educational Initiatives: A Systematic Review.", "authors": [{"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}, {"family": "Dulebenets", "given": "Maxim A", "initials": "MA"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}], "type": "journal article", "published": "2021-05-30", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "11", "issn-l": null}, "abstract": "In the absence of a specific treatment or vaccines, public health strategies are the main measures to use in the initial stages of a pandemic to allow surveillance of infectious diseases. During the ongoing global pandemic of coronavirus disease 2019 (COVID-19), several countries initiated various public health strategies, such as contact tracing and quarantine. The present study aims to conduct a systematic literature review to identify the presence of educational initiatives that promote the implementation of public health strategies before public health emergencies, with a special focus on contact tracing applications. Using Science Direct, PubMed, Scopus, and Gothenburg University search engines, all published scientific articles were included, while conference, reports, and non-scientific papers were excluded. The outcomes of the reviewed studies indicate that the effective implementation of public health strategies depends on the peoples' willingness to participate and collaborate with local authorities. Several factors may influence such willingness, of which ethical, psychological, and practical factors seem to be the most important and frequently discussed. Moreover, individual willingness and readiness of a community may also vary based on the acquired level of knowledge about the incident and its cause and available management options. Educational initiatives, proper communication, and timely information at the community level were found to be the necessary steps to counteract misinformation and to promote a successful implementation of public health strategies and attenuate the effects of a pandemic. The systematic review conducted as a part of this study would benefit the relevant stakeholders and policy makers and assist with effective designing and implementation.", "doi": "10.3390/ijerph18115888", "pmid": "34070882", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijerph18115888"}], "notes": [], "created": "2021-06-04T11:17:15.017Z", "modified": "2021-06-04T11:18:07.146Z"}, {"entity": "publication", "iuid": "68875bb1de464d308d1429a8cde63cf1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68875bb1de464d308d1429a8cde63cf1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68875bb1de464d308d1429a8cde63cf1"}}, "title": "The healthier healthcare management models for COVID-19.", "authors": [{"family": "Mishra", "given": "Anshuman", "initials": "A"}, {"family": "Basumallick", "given": "Srijita", "initials": "S"}, {"family": "Lu", "given": "Albert", "initials": "A"}, {"family": "Chiu", "given": "Helen", "initials": "H"}, {"family": "Shah", "given": "Mohammad A", "initials": "MA"}, {"family": "Shukla", "given": "Yogesh", "initials": "Y"}, {"family": "Tiwari", "given": "Ashutosh", "initials": "A"}], "type": "journal article", "published": "2021-05-29", "journal": {"title": "J Infect Public Health", "issn": "1876-035X", "issn-l": null, "volume": "14", "issue": "7", "pages": "927-937"}, "abstract": "The worldwide pandemic situation of COVID-19 generates a situation in which healthcare resources such as diagnostic kits, drugs and basic healthcare infrastructure were on shortage throughout the period, along with negative impact on socio-economic system. Standardized public healthcare models were missing in pandemic situation, covering from hospitalized patient care to local resident's healthcare managements in terms of monitoring, assess to diagnosis and medicines. This exploratory and intervention-based study with the objective of proposing COVID-19 Care Management Model representing comprehensive care of society including patients (COVID-19 and other diseases) and healthy subjects under integrated framework of healthier management model. Shifting policy towards technology-oriented models with well-aligned infrastructure can achieve better outcomes in COVID-19 prevention and care. The planned development of technical healthcare models for prognosis and improved treatment outcomes that take into account not only genomics, proteomics, nanotechnology, materials science perspectives but also the possible contribution of advanced digital technologies is best strategies for early diagnosis and infections control. In view of current pandemic, a Healthier Healthcare Management Model is proposed here as a source of standardized care having technology support, medical consultation, along with public health model of sanitization, distancing and contact less behaviours practices. Effective healthcare managements have been the main driver of healthier society where, positive action at identified research, technology and management segment more specifically public health, patient health, technology selection and political influence has great potential to enhanced the global response to COVID-19. The implementation of such practices will deliver effective diagnosis and control mechanism and make healthier society.", "doi": "10.1016/j.jiph.2021.05.014", "pmid": "34119847", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1876-0341(21)00131-3"}], "notes": [], "created": "2021-06-14T14:22:40.557Z", "modified": "2021-06-17T07:26:04.930Z"}, {"entity": "publication", "iuid": "d4931e50718e4eeb962ecdc1c2af67ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4931e50718e4eeb962ecdc1c2af67ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4931e50718e4eeb962ecdc1c2af67ff"}}, "title": "Immunogenicity of a first dose of mRNA- or vector-based SARS-CoV-2 vaccination in dialysis patients: a multicenter prospective observational pilot study.", "authors": [{"family": "Lesny", "given": "Paul", "initials": "P"}, {"family": "Anderson", "given": "Mark", "initials": "M"}, {"family": "Cloherty", "given": "Gavin", "initials": "G"}, {"family": "Stec", "given": "Michael", "initials": "M"}, {"family": "Haase-Fielitz", "given": "Anja", "initials": "A"}, {"family": "Haarhaus", "given": "Mathias", "initials": "M"}, {"family": "Santos", "given": "Carla", "initials": "C"}, {"family": "Lucas", "given": "Carlos", "initials": "C"}, {"family": "Macario", "given": "Fernando", "initials": "F"}, {"family": "Haase", "given": "Michael", "initials": "M"}], "type": "letter", "published": "2021-05-29", "journal": {"title": "J Nephrol", "issn": "1724-6059", "volume": null, "issue": null, "issn-l": null}, "abstract": "Dialysis patients are at risk for lower SARS-CoV-2-vaccine immunogenicity than the normal population. We assessed immunogenicity to a first mRNA- or vector-based SARS-CoV-2-vaccination dose in dialysis patients.\n\nIn a multicenter observational pilot study, 2 weeks after a first vaccination (BNT162b2/Pfizer-BioNTech [Comirnaty] or ChAdOx1 nCoV-19/Oxford-Astra-Zeneca [Vaxzevria]), hemodialysis patients (N = 23), peritoneal dialysis patients (N = 4) and healthy staff (N = 14) were tested for SARS-CoV-2-spike IgG/IgM, Nucleocapsid-protein-IgG-antibodies and plasma ACE2-receptor-binding-inhibition capacity. Hemodialysis patients who had had prior COVID-19 infection (N = 18) served as controls. Both response to first SARS-CoV-2 vaccination and IgG spike-positivity following prior COVID-19 infection were defined as SARS-CoV-2 spike IgG levels \u2265 50 AU/mL.\n\nVaccination responder rates were 17.4% (4/23) in hemodialysis patients, 100% (4/4) in peritoneal dialysis patients and 57.1% (8/14) in staff (HD vs. PD: p = 0.004, HD vs. staff: p = 0.027). Among hemodialysis patients, type of vaccine (Comirnaty N = 11, Vaxzevria N = 12, 2 responders each) did not appear to influence antibody levels (IgG spike: Comirnaty median 0.0 [1.-3. quartile 0.0-3.8] versus Vaxzevria 4.3 [1.6-20.1] AU/mL, p = 0.079). Of responders to the first dose of SARS-CoV-2 vaccination among hemodialysis patients (N = 4/23), median IgG spike levels and ACE2-receptor-binding-inhibition capacity were lower than that of IgG spike-positive hemodialysis patients with prior COVID-19 infection (13/18, 72.2%): IgG spike: median 222.0, 1.-3. quartile 104.1-721.9 versus median 3794.6, 1.-3. quartile 793.4-9357.9 AU/mL, p = 0.015; ACE2-receptor-binding-inhibition capacity: median 11.5%, 1.-3. quartile 5.0-27.3 versus median 74.8%, 1.-3. quartile 44.9-98.1, p = 0.002.\n\nTwo weeks after their first mRNA- or vector-based SARS-CoV-2 vaccination, hemodialysis patients demonstrated lower antibody-related response than peritoneal dialysis patients and healthy staff or unvaccinated hemodialysis patients following prior COVID-19 infection.", "doi": "10.1007/s40620-021-01076-0", "pmid": "34050904", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40620-021-01076-0"}, {"db": "pmc", "key": "PMC8164063"}], "notes": [], "created": "2021-06-04T11:36:25.252Z", "modified": "2021-06-04T11:36:25.255Z"}, {"entity": "publication", "iuid": "2a3f46daaab347e1ae1cf81f945c32df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2a3f46daaab347e1ae1cf81f945c32df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2a3f46daaab347e1ae1cf81f945c32df"}}, "title": "High-throughput immunoassays for SARS-CoV-2 - considerable differences in performance when comparing three methods.", "authors": [{"family": "Ekelund", "given": "Oskar", "initials": "O"}, {"family": "Ekblom", "given": "Kim", "initials": "K"}, {"family": "Somajo", "given": "Sofia", "initials": "S"}, {"family": "Pattison-Granberg", "given": "Johanna", "initials": "J"}, {"family": "Olsson", "given": "Karl", "initials": "K"}, {"family": "Petersson", "given": "Annika", "initials": "A"}], "type": "journal article", "published": "2021-05-29", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "volume": null, "issue": null, "pages": "1-6", "issn-l": "2374-4235"}, "abstract": "The recently launched high-throughput assays for detecting antibodies against SARS-CoV-2 has contributed to the managing strategies for the COVID-19 pandemic. This study aimed to investigate the performance of three high-throughput assays and one rapid lateral flow test relative to regulatory authorities' recommended criteria.\n\nA total of 315 samples, including 150 pre-pandemic samples, 152 samples from SARS-CoV-2 RT-PCR positive individuals and 13 potentially cross-reactive samples were analysed with SARS-CoV-2 IgG (Abbott, Abbott Park, IL), Elecsys Anti-SARS-CoV-2 (Roche, Solna, Sweden), LIAISON SARS-CoV-2 S1/S2 IgG (DiaSorin, Saluggia, Italy) and 2019-nCOV IgG/IgM Rapid Test (Dynamiker Biotechnology Co., Tianjin, China).\n\nAll assays performed with a high level of specificity ranging from 96.7% to 99.3%. Sensitivity differed more between the assays, Roche exhibiting the highest sensitivity of 98.7%. The corresponding figures for Abbott, DiaSorin and Dynamiker Biotechnology were 80.9%, 89.0% and 72.4%, respectively.\n\nThe results of the evaluated SARS-CoV-2 assays vary considerably, as well as their ability to fulfil the performance criteria proposed by regulatory authorities. Introduction into clinical use in low-prevalent settings, should, therefore, be made with caution.", "doi": "10.1080/23744235.2021.1931434", "pmid": "34053400", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Proteins": null}, "xrefs": [], "notes": [], "created": "2021-06-04T11:30:48.052Z", "modified": "2021-06-04T11:30:48.055Z"}, {"entity": "publication", "iuid": "d1b37ba4b2974fd7a47738328a38bcc7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1b37ba4b2974fd7a47738328a38bcc7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1b37ba4b2974fd7a47738328a38bcc7"}}, "title": "Dysregulation of COVID-19 related gene expression in the COPD lung.", "authors": [{"family": "Watson", "given": "Alastair", "initials": "A"}, {"family": "\u00d6berg", "given": "Lisa", "initials": "L"}, {"family": "Angermann", "given": "Bastian", "initials": "B"}, {"family": "Spalluto", "given": "C Mirella", "initials": "CM"}, {"family": "H\u00fchn", "given": "Michael", "initials": "M"}, {"family": "Burke", "given": "Hannah", "initials": "H"}, {"family": "Cellura", "given": "Doriana", "initials": "D"}, {"family": "Freeman", "given": "Anna", "initials": "A"}, {"family": "Muthas", "given": "Daniel", "initials": "D"}, {"family": "Etal", "given": "Damla", "initials": "D"}, {"family": "Belfield", "given": "Graham", "initials": "G"}, {"family": "Karlsson", "given": "Fredrik", "initials": "F"}, {"family": "Nordstr\u00f6m", "given": "Karl", "initials": "K"}, {"family": "Ostridge", "given": "Kris", "initials": "K"}, {"family": "Staples", "given": "Karl J", "initials": "KJ"}, {"family": "Wilkinson", "given": "Tom", "initials": "T"}, {"family": "MICA II Studygroup", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-29", "journal": {"title": "Respir Res", "issn": "1465-993X", "volume": "22", "issue": "1", "pages": "164", "issn-l": "1465-9921"}, "abstract": "Chronic obstructive pulmonary disease (COPD) patients are at increased risk of poor outcome from Coronavirus disease (COVID-19). Early data suggest elevated Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) receptor angiotensin converting enzyme 2 (ACE2) expression, but relationships to disease phenotype and downstream regulators of inflammation in the Renin-Angiotensin system (RAS) are unknown. We aimed to determine the relationship between RAS gene expression relevant to SARS-CoV-2 infection in the lung with disease characteristics in COPD, and the regulation of newly identified SARS-CoV-2 receptors and spike-cleaving proteases, important for SARS-CoV-2 infection.\n\nWe quantified gene expression using RNA sequencing of epithelial brushings and bronchial biopsies from 31 COPD and 37 control subjects.\n\nACE2 gene expression (log2-fold change (FC)) was increased in COPD compared to ex-smoking (HV-ES) controls in epithelial brushings (0.25, p = 0.042) and bronchial biopsies (0.23, p = 0.050), and correlated with worse lung function (r = - 0.28, p = 0.0090). ACE2 was further increased in frequent exacerbators compared to infrequent exacerbators (0.51, p = 0.00045) and associated with use of ACE inhibitors (ACEi) (0.50, p = 0.0034), having cardiovascular disease (0.23, p = 0.048) or hypertension (0.34, p = 0.0089), and inhaled corticosteroid use in COPD subjects in bronchial biopsies (0.33, p = 0.049). Angiotensin II receptor type (AGTR)1 and 2 expression was decreased in COPD bronchial biopsies compared to HV-ES controls with log2FC of -0.26 (p = 0.033) and - 0.40, (p = 0.0010), respectively. However, the AGTR1:2 ratio was increased in COPD subjects compared with HV-ES controls, log2FC of 0.57 (p = 0.0051). Basigin, a newly identified potential SARS-CoV-2 receptor was also upregulated in both brushes, log2FC of 0.17 (p = 0.0040), and bronchial biopsies, (log2FC of 0.18 (p = 0.017), in COPD vs HV-ES. Transmembrane protease, serine (TMPRSS)2 was not differentially regulated between control and COPD. However, various other spike-cleaving proteases were, including TMPRSS4 and Cathepsin B, in both epithelial brushes (log2FC of 0.25 (p = 0.0012) and log2FC of 0.56 (p = 5.49E-06), respectively) and bronchial biopsies (log2FC of 0.49 (p = 0.00021) and log2FC of 0.246 (p = 0.028), respectively).\n\nThis study identifies key differences in expression of genes related to susceptibility and aetiology of COVID-19 within the COPD lung. Further studies to understand the impact on clinical course of disease are now required.", "doi": "10.1186/s12931-021-01755-3", "pmid": "34051791", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12931-021-01755-3"}], "notes": [], "created": "2021-06-04T11:33:58.818Z", "modified": "2021-06-04T11:35:52.210Z"}, {"entity": "publication", "iuid": "da0a1e3edde34e98982fa9faf6c59de4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/da0a1e3edde34e98982fa9faf6c59de4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/da0a1e3edde34e98982fa9faf6c59de4"}}, "title": "What drives transmission of severe acute respiratory syndrome coronavirus 2?", "authors": [{"family": "Andersson", "given": "Jan", "initials": "J"}], "type": "editorial", "published": "2021-05-28", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": null, "issue": null, "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic represents the most severe public health crisis of the last 100 years both in terms of societal impact and illness. As of May 10 th more than 155 million individuals have contracted COVID-19 and more than 3,3 million have died from the disease. Even though the underlying pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a member of the coronavirus family that has been studied extensively for many decades, the world was ill-prepared to deal with its high degree of contagion combined with its broad spectrum of virulence. Regretfully, knowledge gained about the physical underpinnings of respiratory viral transmission after the 1918 Spanish flu pandemic was largely ignored by the public health community at the outset of the COVID-19 pandemic.", "doi": "10.1111/joim.13335", "pmid": "34048113", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-29T16:28:03.282Z", "modified": "2021-05-29T16:28:03.294Z"}, {"entity": "publication", "iuid": "6908fbc9bddc495a9c868ac16f0fbc33", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6908fbc9bddc495a9c868ac16f0fbc33.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6908fbc9bddc495a9c868ac16f0fbc33"}}, "title": "Prevalence and Predictors of Loneliness Among Youth During the Time of COVID-19: A Multinational Study.", "authors": [{"family": "Al Omari", "given": "Omar", "initials": "O"}, {"family": "Al Sabei", "given": "Sulaiman", "initials": "S"}, {"family": "Al Rawajfah", "given": "Omar", "initials": "O"}, {"family": "Abu Sharour", "given": "Loai", "initials": "L"}, {"family": "Al-Hashmi", "given": "Iman", "initials": "I"}, {"family": "Al Qadire", "given": "Mohammad", "initials": "M"}, {"family": "Khalaf", "given": "Atika", "initials": "A"}], "type": "journal article", "published": "2021-05-28", "journal": {"title": "J Am Psychiatr Nurses Assoc", "issn": "1532-5725", "volume": null, "issue": null, "pages": "10783903211017640", "issn-l": null}, "abstract": "Given the restrictions associated with COVID-19, feelings of loneliness among youth may increase.\n\nThe aims of the current study were to assess the prevalence of loneliness among young people at the time of COVID-19 and to identify whether selected variables related to the pandemic predicted the level of loneliness.\n\nA cross-sectional study using WhatsApp and Facebook social media platforms was conducted to survey 1,057 young people aged 15 to 24 years from six Middle Eastern countries. Participants completed survey items including demographic and COVID-19-related questions; the Depression, Anxiety and Stress Scale (DASS); the Satisfaction With Life Scale (SWLS); and the UCLA Loneliness Scale.\n\nThe prevalence of experienced loneliness was 1 (0.1%), 625 (59.1%), 429 (40.6%), and 2 (0.2%), reflecting low, moderate, moderately high, and high experiences for loneliness, respectively. History of depression or anxiety, being dissatisfied with life, and having depression at the time of COVID-19 were significant predictors of loneliness among youth. The model was significant ( F = 44.95, p < .05) and accounted for 29.8% of the variance in UCLA Loneliness Scale scores.\n\nWe found that the high prevalence rate of loneliness during the COVID-19 pandemic was correlated with depression and impaired life satisfaction among Middle Eastern youth. Thus, special attention and interventional action plans need to be developed taking into consideration the youths' special situation during COVID-19.", "doi": "10.1177/10783903211017640", "pmid": "34047225", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-29T15:22:40.898Z", "modified": "2021-05-29T15:22:40.921Z"}, {"entity": "publication", "iuid": "49d31b83abc549c9b2c040fa0690d771", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49d31b83abc549c9b2c040fa0690d771.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49d31b83abc549c9b2c040fa0690d771"}}, "title": "Letter to the editor regarding the Topical Review \"Silent hypoxaemia in COVID-19 patients\" by Simonson et al. 2021.", "authors": [{"family": "Mulder", "given": "Eric", "initials": "E"}, {"family": "Pernett", "given": "Frank", "initials": "F"}, {"family": "Schagatay", "given": "Erika", "initials": "E"}], "type": "letter", "published": "2021-05-28", "journal": {"title": "J Physiol", "issn": "1469-7793", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1113/JP281882", "pmid": "34047369", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-29T15:21:48.640Z", "modified": "2021-05-29T15:21:48.656Z"}, {"entity": "publication", "iuid": "4bddd32590714a84adae0eb53060c511", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4bddd32590714a84adae0eb53060c511.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4bddd32590714a84adae0eb53060c511"}}, "title": "Incidence and Severity of Covid-19 in Patients with and without Previously Verified Infections with Common Cold Coronaviruses.", "authors": [{"family": "Ringlander", "given": "Johan", "initials": "J", "orcid": "0000-0002-8483-6504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/64f85af7dceb436498422e62f1a98c89.json"}}, {"family": "Martner", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Westin", "given": "Johan", "initials": "J"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Hellstrand", "given": "Kristoffer", "initials": "K"}], "type": "letter", "published": "2021-05-28", "journal": {"title": "The Journal of Infectious Diseases", "issn": "1537-6613", "issn-l": "0022-1899", "volume": "223", "issue": "10", "pages": "1831-1832"}, "abstract": null, "doi": "10.1093/infdis/jiab089", "pmid": "33780548", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6199850"}, {"db": "pmc", "key": "PMC8083637"}], "notes": [], "created": "2021-03-31T08:12:57.627Z", "modified": "2021-06-14T14:21:11.954Z"}, {"entity": "publication", "iuid": "95af6fdd90c945bb8a6026c4fd1d2092", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95af6fdd90c945bb8a6026c4fd1d2092.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95af6fdd90c945bb8a6026c4fd1d2092"}}, "title": "Associations of baseline use of biologic or targeted synthetic DMARDs with COVID-19 severity in rheumatoid arthritis: Results from the COVID-19 Global Rheumatology Alliance physician registry.", "authors": [{"family": "Sparks", "given": "Jeffrey A", "initials": "JA"}, {"family": "Wallace", "given": "Zachary S", "initials": "ZS"}, {"family": "Seet", "given": "Andrea M", "initials": "AM"}, {"family": "Gianfrancesco", "given": "Milena A", "initials": "MA"}, {"family": "Izadi", "given": "Zara", "initials": "Z"}, {"family": "Hyrich", "given": "Kimme L", "initials": "KL"}, {"family": "Strangfeld", "given": "Anja", "initials": "A"}, {"family": "Gossec", "given": "Laure", "initials": "L"}, {"family": "Carmona", "given": "Loreto", "initials": "L"}, {"family": "Mateus", "given": "Elsa F", "initials": "EF"}, {"family": "Lawson-Tovey", "given": "Saskia", "initials": "S"}, {"family": "Trupin", "given": "Laura", "initials": "L"}, {"family": "Rush", "given": "Stephanie", "initials": "S"}, {"family": "Katz", "given": "Patricia", "initials": "P"}, {"family": "Schmajuk", "given": "Gabriela", "initials": "G"}, {"family": "Jacobsohn", "given": "Lindsay", "initials": "L"}, {"family": "Wise", "given": "Leanna", "initials": "L"}, {"family": "Gilbert", "given": "Emily L", "initials": "EL"}, {"family": "Duarte-Garc\u00eda", "given": "Ali", "initials": "A"}, {"family": "Valenzuela-Almada", "given": "Maria O", "initials": "MO"}, {"family": "Pons-Estel", "given": "Guillermo J", "initials": "GJ"}, {"family": "Isnardi", "given": "Carolina A", "initials": "CA"}, {"family": "Berbotto", "given": "Guillermo A", "initials": "GA"}, {"family": "Hsu", "given": "Tiffany Y-T", "initials": "TY"}, {"family": "D'Silva", "given": "Kristin M", "initials": "KM"}, {"family": "Patel", "given": "Naomi J", "initials": "NJ"}, {"family": "Kearsley-Fleet", "given": "Lianne", "initials": "L"}, {"family": "Sch\u00e4fer", "given": "Martin", "initials": "M"}, {"family": "Ribeiro", "given": "Sandra L\u00facia Euz\u00e9bio", "initials": "SLE"}, {"family": "Al Emadi", "given": "Samar", "initials": "S"}, {"family": "Tidblad", "given": "Liselotte", "initials": "L"}, {"family": "Scir\u00e8", "given": "Carlo Alberto", "initials": "CA"}, {"family": "Raffeiner", "given": "Bernd", "initials": "B"}, {"family": "Thomas", "given": "Thierry", "initials": "T"}, {"family": "Flipo", "given": "Ren\u00e9-Marc", "initials": "RM"}, {"family": "Avouac", "given": "J\u00e9r\u00f4me", "initials": "J"}, {"family": "Seror", "given": "Rapha\u00e8le", "initials": "R"}, {"family": "Bernardes", "given": "Miguel", "initials": "M"}, {"family": "Cunha", "given": "Maria Margarida", "initials": "MM"}, {"family": "Hasseli", "given": "Rebecca", "initials": "R"}, {"family": "Schulze-Koops", "given": "Hendrik", "initials": "H"}, {"family": "M\u00fcller-Ladner", "given": "Ulf", "initials": "U"}, {"family": "Specker", "given": "Christof", "initials": "C"}, {"family": "Souza", "given": "Viviane Angelina de", "initials": "VA"}, {"family": "Mota", "given": "Licia Maria Henrique da", "initials": "LMHD"}, {"family": "Gomides", "given": "Ana Paula Monteiro", "initials": "APM"}, {"family": "Dieud\u00e9", "given": "Philippe", "initials": "P"}, {"family": "Nikiphorou", "given": "Elena", "initials": "E"}, {"family": "Kronzer", "given": "Vanessa L", "initials": "VL"}, {"family": "Singh", "given": "Namrata", "initials": "N"}, {"family": "Ugarte-Gil", "given": "Manuel F", "initials": "MF"}, {"family": "Wallace", "given": "Beth", "initials": "B"}, {"family": "Akpabio", "given": "Akpabio", "initials": "A"}, {"family": "Thomas", "given": "Ranjeny", "initials": "R"}, {"family": "Bhana", "given": "Suleman", "initials": "S"}, {"family": "Costello", "given": "Wendy", "initials": "W"}, {"family": "Grainger", "given": "Rebecca", "initials": "R"}, {"family": "Hausmann", "given": "Jonathan S", "initials": "JS"}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Sufka", "given": "Paul", "initials": "P"}, {"family": "Robinson", "given": "Philip C", "initials": "PC"}, {"family": "Machado", "given": "Pedro M", "initials": "PM"}, {"family": "Yazdany", "given": "Jinoos", "initials": "J"}, {"family": "COVID-19 Global Rheumatology Alliance", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-28", "journal": {"title": "Ann Rheum Dis", "issn": "1468-2060", "volume": null, "issue": null, "issn-l": null}, "abstract": "To investigate baseline use of biologic or targeted synthetic (b/ts) disease-modifying antirheumatic drugs (DMARDs) and COVID-19 outcomes in rheumatoid arthritis (RA).\n\nWe analysed the COVID-19 Global Rheumatology Alliance physician registry (from 24 March 2020 to 12 April 2021). We investigated b/tsDMARD use for RA at the clinical onset of COVID-19 (baseline): abatacept (ABA), rituximab (RTX), Janus kinase inhibitors (JAKi), interleukin 6 inhibitors (IL-6i) or tumour necrosis factor inhibitors (TNFi, reference group). The ordinal COVID-19 severity outcome was (1) no hospitalisation, (2) hospitalisation without oxygen, (3) hospitalisation with oxygen/ventilation or (4) death. We used ordinal logistic regression to estimate the OR (odds of being one level higher on the ordinal outcome) for each drug class compared with TNFi, adjusting for potential baseline confounders.\n\nOf 2869 people with RA (mean age 56.7 years, 80.8% female) on b/tsDMARD at the onset of COVID-19, there were 237 on ABA, 364 on RTX, 317 on IL-6i, 563 on JAKi and 1388 on TNFi. Overall, 613 (21%) were hospitalised and 157 (5.5%) died. RTX (OR 4.15, 95% CI 3.16 to 5.44) and JAKi (OR 2.06, 95% CI 1.60 to 2.65) were each associated with worse COVID-19 severity compared with TNFi. There were no associations between ABA or IL6i and COVID-19 severity.\n\nPeople with RA treated with RTX or JAKi had worse COVID-19 severity than those on TNFi. The strong association of RTX and JAKi use with poor COVID-19 outcomes highlights prioritisation of risk mitigation strategies for these people.", "doi": "10.1136/annrheumdis-2021-220418", "pmid": "34049860", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "annrheumdis-2021-220418"}], "notes": [], "created": "2021-06-04T11:39:56.896Z", "modified": "2021-06-04T11:39:56.913Z"}, {"entity": "publication", "iuid": "20a58e6949654e17abb103cef04c1ee9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/20a58e6949654e17abb103cef04c1ee9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/20a58e6949654e17abb103cef04c1ee9"}}, "title": "Acuity level of care as a predictor of case fatality and prolonged hospital stay in patients with COVID-19: a hospital-based observational follow-up study from Pakistan.", "authors": [{"family": "Almas", "given": "Aysha", "initials": "A"}, {"family": "Mushtaq", "given": "Zain", "initials": "Z"}, {"family": "Moller", "given": "Jette", "initials": "J"}], "type": "journal article", "published": "2021-05-28", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "5", "pages": "e045414"}, "abstract": "To determine if there is an association between acuity level of care (ALC), case fatality and length of stay in patients admitted to hospital due to COVID-19.\r\n\r\nA hospital-based observational follow-up study.\r\n\r\nInternal Medicine Service of the Aga Khan University Hospital, Pakistan, from 26 February 2020 to 30 June 2020.\r\n\r\nAdult patients with confirmed COVID-19, aged \u226518 years.\r\n\r\nALC was categorised into low, intermediate and high level and patients were triaged using the standard emergency severity illness score. All patients were followed until the end of hospital admission for the outcome of case fatality and length of stay.\r\n\r\nA total of 822 patients with COVID-19 were admitted during the study period and 699 met inclusion criteria. The mean age was 54.5 years and 67% were males; 50.4% were triaged to low, 42.5% to intermediate and 7.2% to high acuity care. The overall case-fatality rate was 11.6%, with the highest (52%) in high acuity level followed by 16.2% in intermediate and 2% in low acuity care. Acuity level was associated with case fatality, with an HR (95% CI) of 5.0 (2.0 to 12.1) for high versus low acuity care and an HR of 2.7 (1.2, 6.4) for intermediate versus low acuity care, after adjusting for age, sex and common comorbidities including diabetes, hypertension, ischaemic heart disease and chronic lung disease. Similarly, acuity level was also associated with length of hospital stay.\r\n\r\nHigh and intermediate acuity level is associated with higher case fatality rate and prolonged length of hospital stay in patients admitted with COVID-19. In resource-limited settings where the provision of high acuity care is limited, the intermediate care acuity could serve as a useful strategy to treat relatively less critical patients with COVID-19.", "doi": "10.1136/bmjopen-2020-045414", "pmid": "34049912", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-045414"}], "notes": [], "created": "2021-06-04T11:39:03.792Z", "modified": "2021-07-14T09:07:44.390Z"}, {"entity": "publication", "iuid": "428c57c97b5143e58cc7f7f5d705cb70", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/428c57c97b5143e58cc7f7f5d705cb70.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/428c57c97b5143e58cc7f7f5d705cb70"}}, "title": "Mortality in adult patients with solid or hematological malignancies and SARS-CoV-2 infection with a specific focus on lung and breast malignancies: a systematic review and meta-analysis.", "authors": [{"family": "Tagliamento", "given": "Marco", "initials": "M"}, {"family": "Agostinetto", "given": "Elisa", "initials": "E"}, {"family": "Bruzzone", "given": "Marco", "initials": "M"}, {"family": "Ceppi", "given": "Marcello", "initials": "M"}, {"family": "Saini", "given": "Kamal S", "initials": "KS"}, {"family": "de Azambuja", "given": "Evandro", "initials": "E"}, {"family": "Punie", "given": "Kevin", "initials": "K"}, {"family": "Westphalen", "given": "C Benedikt", "initials": "CB"}, {"family": "Morgan", "given": "Gilberto", "initials": "G"}, {"family": "Pronzato", "given": "Paolo", "initials": "P"}, {"family": "Del Mastro", "given": "Lucia", "initials": "L"}, {"family": "Poggio", "given": "Francesca", "initials": "F"}, {"family": "Lambertini", "given": "Matteo", "initials": "M"}], "type": "journal article", "published": "2021-05-27", "journal": {"title": "Crit Rev Oncol Hematol", "issn": "1879-0461", "volume": null, "issue": null, "pages": "103365", "issn-l": null}, "abstract": "A systematic review and meta-analysis were performed to estimate the mortality in patients with cancer and SARS-CoV-2 infection.\n\nA systematic search of PubMed, up to 31 January 2021, identified publications reporting the case-fatality rate (CFR) among adult patients with solid and/or hematological malignancies and SARS-CoV-2 infection. The CFR, defined as the rate of death among this population, was assessed with a random effect model; 95% confidence intervals (CI) were calculated.\n\nAmong 135 selected studies (N = 33,879 patients), the CFR was 25.4% (95% CI 22.9%-28.2%). At a sensitivity analysis of studies with at least 100 patients, the CFR was 21.9% (95% CI 19.1%-25.1%). Among COVID-19 patients with lung (N = 1,135) and breast (N = 1,296) cancers, CFR were 32.4% (95% CI 26.5%-39.6%) and 14.2% (95% CI 9.3%-21.8%), respectively.\n\nCOVID-19 patients with lung cancer have a comparatively higher probability of mortality than those with breast cancer.", "doi": "10.1016/j.critrevonc.2021.103365", "pmid": "34052423", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1040-8428(21)00153-0"}], "notes": [], "created": "2021-05-31T16:10:57.629Z", "modified": "2021-06-04T11:33:13.590Z"}, {"entity": "publication", "iuid": "937f550349b9447aa382b9d0ae959148", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/937f550349b9447aa382b9d0ae959148.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/937f550349b9447aa382b9d0ae959148"}}, "title": "Iatrogenic immunosuppression can lead to prolonged viral shedding and absent immune response to COVID-19.", "authors": [{"family": "Psaros Einberg", "given": "A", "initials": "A"}, {"family": "Casswall", "given": "T", "initials": "T"}, {"family": "Arnell", "given": "H", "initials": "H"}, {"family": "Nowak", "given": "G", "initials": "G"}, {"family": "Mirazimi", "given": "A", "initials": "A"}, {"family": "Sundin", "given": "M", "initials": "M"}, {"family": "Fischler", "given": "B", "initials": "B"}], "type": "journal article", "published": "2021-05-27", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": null, "issue": null, "issn-l": "0803-5253"}, "abstract": "In the era of the COVID-19 pandemic, paediatricians need to remember that immunocompromised children might experience prolonged viral shedding and impaired immunological response to SARS-CoV-2. We report a girl diagnosed with an unresectable angiosarcoma of the liver who underwent liver transplantation in June 2019. The basic immunosuppression protocol consisted of tacrolimus and prednisolone. Additionally, she was on adjuvant treatment with trametinib, a mitogen-activated protein kinase (MEK) inhibitor.", "doi": "10.1111/apa.15955", "pmid": "34043855", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-29T15:27:50.514Z", "modified": "2021-05-29T15:28:08.933Z"}, {"entity": "publication", "iuid": "c1a5506828024e04a38f14fd2e79843d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1a5506828024e04a38f14fd2e79843d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1a5506828024e04a38f14fd2e79843d"}}, "title": "Fostering local involvement for biodiversity conservation in tropical regions: Lessons from Madagascar during the COVID-19 pandemic.", "authors": [{"family": "Razanatsoa", "given": "Estelle", "initials": "E", "orcid": "0000-0002-7219-1411", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/454a8b9297fc49e28b40309d49f0f20a.json"}}, {"family": "Andriantsaralaza", "given": "Seheno", "initials": "S", "orcid": "0000-0002-6098-2056", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22ed6f4d679f4b7586604bdeaab878b1.json"}}, {"family": "Holmes", "given": "Sheila M", "initials": "SM", "orcid": "0000-0002-6420-5510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b17dfb2bb1174ca7a174d8f163e137f4.json"}}, {"family": "Rakotonarivo", "given": "O Sarobidy", "initials": "OS", "orcid": "0000-0002-8032-1431", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/836e1a64ab9a406d815ac9eae8407e30.json"}}, {"family": "Ratsifandrihamanana", "given": "Anitry N", "initials": "AN"}, {"family": "Randriamiharisoa", "given": "Lalatiana", "initials": "L"}, {"family": "Ravaloharimanitra", "given": "Maholy", "initials": "M"}, {"family": "Ramahefamanana", "given": "Narindra", "initials": "N"}, {"family": "Tahirinirainy", "given": "Dinasoa", "initials": "D"}, {"family": "Raharimampionona", "given": "Jeannie", "initials": "J"}], "type": "journal article", "published": "2021-05-27", "journal": {"title": "Biotropica", "issn": "0006-3606", "issn-l": null}, "abstract": "Tropical ecosystems host a large proportion of global biodiversity and directly support the livelihoods of many of the world's poorest, and often marginalized, people through ecosystem goods and services and conservation employment. The coronavirus pandemic has challenged existing conservation structures and management but provides an opportunity to re-examine strategies and research approaches across the tropics to build resilience for future crises. Based on the personal experiences of conservation leaders, managers, and researchers from Madagascar during this period, we discuss the coping strategies of multiple biodiversity conservation organizations during the coronavirus pandemic. We highlight the vital role of local communities in building and maintaining resilient conservation practices that are robust to global disruptions such as the COVID-19 crisis. We argue that the integration of local experts and communities in conservation, research, and financial decision-making is essential to a strong foundation for biodiversity conservation in developing countries to stand up to future environmental, political, and health crises. This integration could be achieved through the support of training and capacity building of local researchers and community members and these actions would also enhance the development of strong, equitable long-term collaborations with international communities. Equipped with such capacity, conservationists and researchers from these regions could establish long-term biodiversity conservation strategies that are adapted to local context, and communities could flexibly balance biodiversity and livelihood needs as circumstances change, including weathering the isolation and financial challenges of local or global crises.", "doi": "10.1111/btp.12967", "pmid": "34219750", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "BTP12967"}, {"db": "pmc", "key": "PMC8239783"}], "notes": [], "created": "2021-08-06T08:53:44.583Z", "modified": "2021-08-06T08:53:59.254Z"}, {"entity": "publication", "iuid": "8767c26e5c524de09e1225c60e4f29eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8767c26e5c524de09e1225c60e4f29eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8767c26e5c524de09e1225c60e4f29eb"}}, "title": "Vaccine Inequities, Intellectual Property Rights and Pathologies of Power in the Global Response to COVID-19.", "authors": [{"family": "Engebretsen", "given": "Eivind", "initials": "E", "orcid": "0000-0001-9455-110X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fce6bb59db844a65b3c378ae1e97d867.json"}}, {"family": "Ottersen", "given": "Ole Petter", "initials": "OP"}], "type": "journal article", "published": "2021-05-26", "journal": {"title": "Int J Health Policy Manag", "issn": "2322-5939", "issn-l": null}, "abstract": null, "doi": "10.34172/ijhpm.2021.57", "pmid": "34124871", "labels": [], "xrefs": [], "notes": [], "created": "2021-06-17T07:43:43.010Z", "modified": "2021-06-17T07:43:43.047Z"}, {"entity": "publication", "iuid": "1e4e8c46e7ca4527a361f0c9b526b8d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1e4e8c46e7ca4527a361f0c9b526b8d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1e4e8c46e7ca4527a361f0c9b526b8d0"}}, "title": "Risk of stress/depression and functional impairment in Denmark immediately following a COVID-19 shutdown.", "authors": [{"family": "Andersen", "given": "Lars H", "initials": "LH"}, {"family": "Fallesen", "given": "Peter", "initials": "P"}, {"family": "Bruckner", "given": "Tim A", "initials": "TA"}], "type": "journal article", "published": "2021-05-26", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "984"}, "abstract": "Existing estimates of the impact of the COVID-19 burden on mental wellbeing come from countries with high mortality rates. This study therefore aimed to investigate the impact of the first COVID-19 lockdown (March-April 2020) on risk for stress/depression and functional impairment in a representative sample of adult individuals in Denmark, which had lower infection rates, and whether the impact of lockdown was heterogeneous across living situation.\r\n\r\nUsing a representative, randomly drawn sample from the complete Danish adult population interviewed in March 2 to April 13, 2020 (n = 2836) and again in July 2020 (n = 1526, 54% retention rate), we study how the imposed lockdown announced March 11 following the onset of the first Danish wave of COVID-19 infections affected mental wellbeing. We use the World Health Organization Five Well-being Index (WHO-5) and the Work and Social Adjustment Scale (WSAS) to capture risk for stress/depression (WHO-5 < 50) and functional impairment (WSAS > 10). Using covariate adjusted ordinary least squares linear probability models and exploiting variation in the timing of responses occurring just before and just after the introduction of lockdown, we compare respondents before lockdown to respondents that answered during lockdown, as well as to answers in re-interviews in July.\r\n\r\nIn our fully controlled models, we find reduced depressive symptoms among adults immediately after the shutdown, concentrated in adults with children living at home (-.089, p < .01 (from pre lockdown baseline .273)). Measures of functional impairment also declined immediately after the March shutdown among adults with children living at home (-.066, p < .05 (from pre lockdown baseline .150)). Impairment intensified for the entire sample between March and July (+.199, p < .001 (from pre lockdown baseline .248)), but depressive symptoms remained at lower rate in July (-.033, p < .05 (from pre lockdown baseline .332).\r\n\r\nFindings in Denmark indicate that living with children at home may have, in the short term, buffered the potential mental health sequelae of the COVID-19 shutdown.", "doi": "10.1186/s12889-021-11020-3", "pmid": "34039323", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-11020-3"}], "notes": [], "created": "2021-05-29T15:31:51.419Z", "modified": "2022-11-23T09:00:29.216Z"}, {"entity": "publication", "iuid": "c4684de637ff43ec912ca70bf831a82a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c4684de637ff43ec912ca70bf831a82a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c4684de637ff43ec912ca70bf831a82a"}}, "title": "Fostering global data sharing: highlighting the recommendations of the Research Data Alliance COVID-19 working group", "authors": [{"family": "Austin", "given": "Claire C", "initials": "CC", "orcid": "0000-0001-9138-5986", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c6b7cea2c224961825b7986b7d1f17f.json"}}, {"family": "Bernier", "given": "Alexander", "initials": "A", "orcid": "0000-0001-8615-8375", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93d210c6bb9047daa58cfe87dc53fe52.json"}}, {"family": "Bezuidenhout", "given": "Louise", "initials": "L", "orcid": "0000-0003-4328-3963", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b9fce97de2e4f54b82b06d20695e735.json"}}, {"family": "Bicarregui", "given": "Juan", "initials": "J", "orcid": "0000-0001-5250-7653", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69a0641e17eb47058ac58941c180586b.json"}}, {"family": "Biro", "given": "Timea", "initials": "T", "orcid": "0000-0002-8900-8978", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5e00a6f3933b485898c9524dd5f9dc3a.json"}}, {"family": "Cambon-Thomsen", "given": "Anne", "initials": "A", "orcid": "0000-0001-8793-3644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96673088e61d4699a4197088c6eba954.json"}}, {"family": "Carroll", "given": "Stephanie Russo", "initials": "SR", "orcid": "0000-0002-8996-8071", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bbcfdde655a4415f8a1198811932af90.json"}}, {"family": "Cournia", "given": "Zoe", "initials": "Z", "orcid": "0000-0001-9287-364X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8a80098a1fa4268b4b7321618482e8b.json"}}, {"family": "Dabrowski", "given": "Piotr Wojciech", "initials": "PW", "orcid": "0000-0003-4893-805X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c7b5d2b1ed846538c5d183782864a3c.json"}}, {"family": "Diallo", "given": "Gayo", "initials": "G"}, {"family": "Duflot", "given": "Thomas", "initials": "T", "orcid": "0000-0002-8730-284X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c0158acd3a34521a3fbd36f0ef1d823.json"}}, {"family": "Garcia", "given": "Leyla", "initials": "L", "orcid": "0000-0003-3986-0510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0e247431cfc446599995c672f5d89bc.json"}}, {"family": "Gesing", "given": "Sandra", "initials": "S"}, {"family": "Gonzalez-Beltran", "given": "Alejandra", "initials": "A", "orcid": "0000-0003-3499-8262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12ad5713a3324f83915b8136aa7e43b5.json"}}, {"family": "Gururaj", "given": "Anupama", "initials": "A", "orcid": "0000-0002-4221-4379", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab358e34447c439d90a0cbcf488ccd4f.json"}}, {"family": "Harrower", "given": "Natalie", "initials": "N", "orcid": "0000-0002-7487-4881", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/466ab83cba30459dbe96c178cc371f50.json"}}, {"family": "Lin", "given": "Dawei", "initials": "D"}, {"family": "Medeiros", "given": "Claudia", "initials": "C", "orcid": "0000-0003-1908-4753", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f57ea5f61e384f458245e5f83e5124ac.json"}}, {"family": "M\u00e9ndez", "given": "Eva", "initials": "E", "orcid": "0000-0002-5337-4722", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e2ac979f16f44beb29275697c0bba62.json"}}, {"family": "Meyers", "given": "Natalie", "initials": "N", "orcid": "0000-0001-6441-6716", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3261010fd1d5419aab0011cf7347b86d.json"}}, {"family": "Mietchen", "given": "Daniel", "initials": "D", "orcid": "0000-0001-9488-1870", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5c738bfdab3d4c53a35b92ded513d72d.json"}}, {"family": "Nagrani", "given": "Rajini", "initials": "R", "orcid": "0000-0002-1708-2319", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ef6c842faa8743c5912026afa0d8ebde.json"}}, {"family": "Nilsonne", "given": "Gustav", "initials": "G", "orcid": "0000-0001-5273-0150", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6211be5fc4ce4a63bddae08e6d336f15.json"}}, {"family": "Parker", "given": "Simon", "initials": "S"}, {"family": "Pickering", "given": "Brian", "initials": "B", "orcid": "0000-0002-6815-2938", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ca8df52b7cba413ebab9e6ca55c7d0e2.json"}}, {"family": "Pienta", "given": "Amy", "initials": "A"}, {"family": "Polydoratou", "given": "Panayiota", "initials": "P", "orcid": "0000-0002-7551-8002", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c6bf54582da40eb880813105e82f96b.json"}}, {"family": "Psomopoulos", "given": "Fotis", "initials": "F", "orcid": "0000-0002-0222-4273", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/24743c9924274f449cbebde9c84ccebe.json"}}, {"family": "Rennes", "given": "Stephanie", "initials": "S", "orcid": "0000-0003-1458-7773", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e9c29b5851d4825b59c8c63ac241cbf.json"}}, {"family": "Rowe", "given": "Robyn", "initials": "R", "orcid": "0000-0003-0591-6213", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2cf7aefe4a5c4ceebc2290f40bc0c52f.json"}}, {"family": "Sansone", "given": "Susanna Assunta", "initials": "SA", "orcid": "0000-0001-5306-5690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3989d62ae34542fdbf5840a81957d964.json"}}, {"family": "Shanahan", "given": "Hugh", "initials": "H", "orcid": "0000-0003-1374-6015", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bab1d81eff584e68aaa469009875060c.json"}}, {"family": "Sitz", "given": "Lina", "initials": "L", "orcid": "0000-0002-6333-4986", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8beab9cc751647a6bb33e1ac5764eff8.json"}}, {"family": "Stocks", "given": "Joanne", "initials": "J", "orcid": "0000-0002-7800-6002", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8a546486dd840038ccd2c6f788f0ab9.json"}}, {"family": "Tovani-Palone", "given": "Marcos Roberto", "initials": "MR"}, {"family": "Uhlmansiek", "given": "Mary", "initials": "M", "orcid": "0000-0002-7949-2057", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9cc1455ca3f84309aac4f635c863b1ff.json"}}, {"family": null, "given": "", "initials": ""}], "type": "journal-article", "published": "2021-05-26", "journal": {"title": "Wellcome Open Res", "issn": "2398-502X", "volume": "5", "pages": "267", "issn-l": null}, "abstract": "The systemic challenges of the COVID-19 pandemic require cross-disciplinary collaboration in a global and timely fashion. Such collaboration needs open research practices and the sharing of research outputs, such as data and code, thereby facilitating research and research reproducibility and timely collaboration beyond borders. The Research Data Alliance COVID-19 Working Group recently published a set of recommendations and guidelines on data sharing and related best practices for COVID-19 research. These guidelines include recommendations for clinicians, researchers, policy- and decision-makers, funders, publishers, public health experts, disaster preparedness and response experts, infrastructure providers from the perspective of different domains (Clinical Medicine, Omics, Epidemiology, Social Sciences, Community Participation, Indigenous Peoples, Research Software, Legal and Ethical Considerations), and other potential users. These guidelines include recommendations for researchers, policymakers, funders, publishers and infrastructure providers from the perspective of different domains (Clinical Medicine, Omics, Epidemiology, Social Sciences, Community Participation, Indigenous Peoples, Research Software, Legal and Ethical Considerations). Several overarching themes have emerged from this document such as the need to balance the creation of data adherent to FAIR principles (findable, accessible, interoperable and reusable), with the need for quick data release; the use of trustworthy research data repositories; the use of well-annotated data with meaningful metadata; and practices of documenting methods and software. The resulting document marks an unprecedented cross-disciplinary, cross-sectoral, and cross-jurisdictional effort authored by over 160 experts from around the globe. This letter summarises key points of the Recommendations and Guidelines, highlights the relevant findings, shines a spotlight on the process, and suggests how these developments can be leveraged by the wider scientific community.", "doi": "10.12688/wellcomeopenres.16378.2", "pmid": "33501381", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7808050.2"}], "notes": [], "created": "2021-06-11T05:08:48.036Z", "modified": "2021-06-11T05:10:26.069Z"}, {"entity": "publication", "iuid": "1ee3f6241f5342e398bfae010ed8574f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ee3f6241f5342e398bfae010ed8574f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ee3f6241f5342e398bfae010ed8574f"}}, "title": "Diagnostic Potential of a Luminex-Based Coronavirus Disease 2019 Suspension Immunoassay (COVID-19 SIA) for the Detection of Antibodies against SARS-CoV-2.", "authors": [{"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Kolstad", "given": "Linda", "initials": "L"}, {"family": "Lindahl", "given": "Johanna F", "initials": "JF"}, {"family": "Albinsson", "given": "Bo", "initials": "B"}, {"family": "Bergqvist", "given": "Anders", "initials": "A"}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "journal article", "published": "2021-05-26", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "13", "issue": "6", "pages": null}, "abstract": "Due to the current, rapidly increasing Coronavirus disease 2019 (COVID-19) pandemic, efficient and highly specific diagnostic methods are needed. The receptor-binding part of the spike (S) protein, S1, has been suggested to be highly virus-specific; it does not cross-react with antibodies against other coronaviruses. Three recombinant partial S proteins of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) expressed in mammalian or baculovirus-insect cells were evaluated as antigens in a Luminex-based suspension immunoassay (SIA). The best performing antigen (S1; amino acids 16-685) was selected and further evaluated by serum samples from 76 Swedish patients or convalescents with COVID-19 (previously PCR and/or serologically confirmed), 200 pre-COVID-19 individuals (180 blood donors and 20 infants), and 10 patients with acute Epstein-Barr virus infection. All 76 positive samples showed detectable antibodies to S1, while none of the 210 negative controls gave a false positive antibody reaction. We further compared the COVID-19 SIA with a commercially available enzyme immunoassay and a previously evaluated COVID-19 rapid antibody test. The results revealed an overall assay sensitivity of 100%, a specificity of 100% for both IgM and IgG, a quantitative ability at concentrations up to 25 BAU/mL, and a better performance as compared to the commercial assays, suggesting the COVID-19 SIA as a most valuable tool for efficient laboratory-based serology.", "doi": "10.3390/v13060993", "pmid": "34073484", "labels": {"Category: Other": null, "Type: Journal article": null, "Funder: H2020": null, "Funder: VR": null, "Category: Biochemistry": null, "Research Area: High-throughput and high-content serology": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "pii", "key": "v13060993"}], "notes": [], "created": "2021-06-04T11:11:07.153Z", "modified": "2021-08-25T08:17:08.764Z"}, {"entity": "publication", "iuid": "9e8e9c1414cb4a1d8985ebb84f523153", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9e8e9c1414cb4a1d8985ebb84f523153.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9e8e9c1414cb4a1d8985ebb84f523153"}}, "title": "Depression, anxiety and stress among Swedish university students before and during six months of the COVID-19 pandemic: A cohort study.", "authors": [{"family": "Johansson", "given": "Fred", "initials": "F"}, {"family": "C\u00f4t\u00e9", "given": "Pierre", "initials": "P"}, {"family": "Hogg-Johnson", "given": "Sheilah", "initials": "S"}, {"family": "Rudman", "given": "Ann", "initials": "A"}, {"family": "Holm", "given": "Lena W", "initials": "LW"}, {"family": "Grotle", "given": "Margreth", "initials": "M"}, {"family": "Jensen", "given": "Irene", "initials": "I"}, {"family": "Sundberg", "given": "Tobias", "initials": "T"}, {"family": "Edlund", "given": "Klara", "initials": "K"}, {"family": "Skillgate", "given": "Eva", "initials": "E"}], "type": "journal article", "published": "2021-05-26", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": null, "issue": null, "pages": "14034948211015814"}, "abstract": "The COVID-19 pandemic has had a profound effect on societies and citizens worldwide, raising concerns about potential mental health impacts. We aimed to describe trajectories of depression, anxiety and stress symptoms during the COVID-19 outbreak compared to before the outbreak, and to determine if trajectories were modified by pre-pandemic loneliness, poor sleep quality and mental health problems.\r\n\r\nWe conducted a cohort study with 1836 Swedish university students entering the study before 13 March 2020, the onset of the pandemic, with follow-ups within three (FU1) and six months (FU2) of the outbreak. Generalized Estimating Equations were used to estimate mean differences in symptom levels over time-periods, and to estimate potential effect modifications.\r\n\r\nWe found small differences in mean levels of the depression, anxiety and stress scale (DASS-21) over time. Compared to before the pandemic, depression increased by 0.25 points of 21 (95% CI: 0.04 to -0.45) at FU1 and decreased by 0.75/21 (95% CI:-0.97 to -0.53) at FU2. Anxiety decreased from baseline to FU1 by 0.09/21 (95% CI: -0.24 to -0.07) and by 0.77/21 (95% CI: -0.93 to -0.61) to FU2. Stress decreased from baseline to FU1 by 0.30/21 (95% CI: -0.52 to -0.09) and by 1.32/21 (95% CI: -1.55 to -1.09) to FU2. Students with pre-pandemic loneliness, poor sleep quality or pre-pandemic mental health problems did not have worse trajectories of mean mental health symptoms.\r\n\r\nSymptom levels were relatively stable during the first three months of the pandemic, while there was a slight decrease during the summer months, probably due to seasonality effects.", "doi": "10.1177/14034948211015814", "pmid": "34034577", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-05-29T15:40:53.363Z", "modified": "2021-07-14T09:04:52.922Z"}, {"entity": "publication", "iuid": "ab5e1324aa344ff6a675dd4c0b159a2f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ab5e1324aa344ff6a675dd4c0b159a2f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ab5e1324aa344ff6a675dd4c0b159a2f"}}, "title": "Multiplexed detection of SARS-CoV-2 and other respiratory infections in high throughput by SARSeq.", "authors": [{"family": "Yelagandula", "given": "Ramesh", "initials": "R"}, {"family": "Bykov", "given": "Aleksandr", "initials": "A"}, {"family": "Vogt", "given": "Alexander", "initials": "A"}, {"family": "Heinen", "given": "Robert", "initials": "R"}, {"family": "\u00d6zkan", "given": "Ezgi", "initials": "E"}, {"family": "Strobl", "given": "Marcus Martin", "initials": "MM"}, {"family": "Baar", "given": "Juliane Christina", "initials": "JC"}, {"family": "Uzunova", "given": "Kristina", "initials": "K"}, {"family": "Hajdusits", "given": "Bence", "initials": "B"}, {"family": "Kordic", "given": "Darja", "initials": "D"}, {"family": "Suljic", "given": "Erna", "initials": "E"}, {"family": "Kurtovic-Kozaric", "given": "Amina", "initials": "A"}, {"family": "Izetbegovic", "given": "Sebija", "initials": "S"}, {"family": "Schaeffer", "given": "Justine", "initials": "J"}, {"family": "Hufnagl", "given": "Peter", "initials": "P"}, {"family": "Zoufaly", "given": "Alexander", "initials": "A"}, {"family": "Seitz", "given": "Tamara", "initials": "T"}, {"family": "VCDI", "given": "", "initials": ""}, {"family": "F\u00f6dinger", "given": "Manuela", "initials": "M"}, {"family": "Allerberger", "given": "Franz", "initials": "F"}, {"family": "Stark", "given": "Alexander", "initials": "A"}, {"family": "Cochella", "given": "Luisa", "initials": "L"}, {"family": "Elling", "given": "Ulrich", "initials": "U"}], "type": "journal article", "published": "2021-05-25", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "3132", "issn-l": "2041-1723"}, "abstract": "The COVID-19 pandemic has demonstrated the need for massively-parallel, cost-effective tests monitoring viral spread. Here we present SARSeq, saliva analysis by RNA sequencing, a method to detect SARS-CoV-2 and other respiratory viruses on tens of thousands of samples in parallel. SARSeq relies on next generation sequencing of multiple amplicons generated in a multiplexed RT-PCR reaction. Two-dimensional, unique dual indexing, using four indices per sample, enables unambiguous and scalable assignment of reads to individual samples. We calibrate SARSeq on SARS-CoV-2 synthetic RNA, virions, and hundreds of human samples of various types. Robustness and sensitivity were virtually identical to quantitative RT-PCR. Double-blinded benchmarking to gold standard quantitative-RT-PCR performed by human diagnostics laboratories confirms this high sensitivity. SARSeq can be used to detect Influenza A and B viruses and human rhinovirus in parallel, and can be expanded for detection of other pathogens. Thus, SARSeq is ideally suited for differential diagnostic of infections during a pandemic.", "doi": "10.1038/s41467-021-22664-5", "pmid": "34035246", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-22664-5"}, {"db": "GEO", "key": "GSE163688", "description": "Sequencing data for all experiments"}, {"db": "URL", "key": "https://www.nature.com/articles/s41467-021-22664-5#MOESM5", "description": "Primer sequences"}], "notes": [], "created": "2021-05-29T15:34:33.669Z", "modified": "2021-11-18T13:05:10.873Z"}, {"entity": "publication", "iuid": "e892756c8c4a415f812888a2f2db458a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e892756c8c4a415f812888a2f2db458a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e892756c8c4a415f812888a2f2db458a"}}, "title": "Impact of lockdown and school closure on children's health and well-being during the first wave of COVID-19: a narrative review.", "authors": [{"family": "Rajmil", "given": "Luis", "initials": "L", "orcid": "0000-0002-6625-0649", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/96b681441723437abfbe49c7af90af6f.json"}}, {"family": "Hjern", "given": "Anders", "initials": "A"}, {"family": "Boran", "given": "Perran", "initials": "P"}, {"family": "Gunnlaugsson", "given": "Geir", "initials": "G"}, {"family": "Kraus de Camargo", "given": "Olaf", "initials": "O"}, {"family": "Raman", "given": "Shanti", "initials": "S", "orcid": "0000-0002-4546-3231", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8dddb7bcfae9429b864a3ff7cbc06c45.json"}}, {"family": "International Society for Social Pediatrics & Child Health (ISSOP) and International Network for Research on Inequalities in Child Health (INRICH) COVID-19 Working Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-25", "journal": {"title": "BMJ Paediatr Open", "issn": "2399-9772", "issn-l": null, "volume": "5", "issue": "1", "pages": "e001043"}, "abstract": "In the context of containment measures against the COVID-19 pandemic, the aims were to examine the impact of lockdown and school closures on childs' and adolescents' health and well-being and social inequalities in health.\r\n\r\nLiterature review by searching five databases until November 2020. We included quantitative peer-reviewed studies reporting health and well-being outcomes in children (0-18 years) related to closure measures' impact due to COVID-19. A pair of authors assessed the risk of bias of included studies. A descriptive and narrative synthesis was carried out.\r\n\r\nTwenty-two studies, including high-income, middle-income and low-income countries, fulfilled our search criteria and were judged not to have an increased risk of bias. Studies from Australia, Spain and China showed an increase in depressive symptoms and decrease in life satisfaction. A decrease in physical activity and increase in unhealthy food consumption were shown in studies from two countries. There was a decrease in the number of visits to the emergency department in four countries, an increase in child mortality in Cameroon and a decrease by over 50% of immunisations administered in Pakistan. A significant drop of 39% in child protection medical examination referrals during 2020 compared with the previous years was found in the UK, a decrease in allegations of child abuse and neglect by almost one-third due to school closures in Florida, and an increase in the number of children with physical child abuse trauma was found in one centre in the USA.\r\n\r\nFrom available reports, pandemic school closure and lockdown have adverse effects on child health and well-being in the short and probably long term. We urge governments to take the negative public health consequences into account before adopting restrictive measures in childhood.", "doi": "10.1136/bmjpo-2021-001043", "pmid": "34192198", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "bmjpo-2021-001043"}, {"db": "pmc", "key": "PMC8154298"}], "notes": [], "created": "2021-07-05T14:26:37.785Z", "modified": "2022-11-23T09:00:53.996Z"}, {"entity": "publication", "iuid": "e50e510d5bf7459e8e856f436a0df30d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e50e510d5bf7459e8e856f436a0df30d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e50e510d5bf7459e8e856f436a0df30d"}}, "title": "Expanding Utilization of Home Dialysis: An Action Agenda From the First International Home Dialysis Roundtable.", "authors": [{"family": "Mendu", "given": "Mallika L", "initials": "ML"}, {"family": "Divino-Filho", "given": "Jos\u00e9 Carolino", "initials": "JC"}, {"family": "Vanholder", "given": "Raymond", "initials": "R"}, {"family": "Mitra", "given": "Sandip", "initials": "S"}, {"family": "Davies", "given": "Simon J", "initials": "SJ"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Damron", "given": "Kelli Collins", "initials": "KC"}, {"family": "Gallego", "given": "Daniel", "initials": "D"}, {"family": "Seger", "given": "Michelle", "initials": "M"}, {"family": "International Home Dialysis Roundtable Steering Committee", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-25", "journal": {"title": "Kidney Med", "issn": "2590-0595", "volume": "3", "issue": "4", "pages": "635-643", "issn-l": null}, "abstract": "In a groundbreaking meeting, leading global kidney disease organizations came together in the fall of 2020 as an International Home Dialysis Roundtable (IHDR) to address strategies to increase access to and uptake of home dialysis, both peritoneal dialysis and home hemodialysis. This challenge has become urgent in the wake of the coronavirus disease 2019 (COVID-19) pandemic, during which patients with advanced kidney disease, who are more susceptible to viral infections and severe complications, must be able to safely physically distance at home. To boost access to home dialysis on a global scale, IHDR members committed to collaborate, through the COVID-19 public health emergency and beyond, to promote uptake of home dialysis on a broad scale. Their commitments included increasing the reach and influence of key stakeholders with policy makers, building a cooperative of advocates and champions for home dialysis, working together to increase patient engagement and empowerment, and sharing intelligence about policy, education, and other programs so that such efforts can be operationalized globally. In the spirit of international cooperation, IHDR members agreed to document, amplify, and replicate established efforts shown to improve access to home dialysis and support new policies that facilitate access through procedures, innovation, and reimbursement.", "doi": "10.1016/j.xkme.2021.04.004", "pmid": "34401729", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2590-0595(21)00100-X"}, {"db": "pmc", "key": "PMC8350829"}], "notes": [], "created": "2021-08-20T12:16:17.141Z", "modified": "2021-08-20T12:16:31.443Z"}, {"entity": "publication", "iuid": "07a32c0bc5e24434929d4ce6ae95b614", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07a32c0bc5e24434929d4ce6ae95b614.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07a32c0bc5e24434929d4ce6ae95b614"}}, "title": "COVID-19 and the selection problem in national cause-of-death statistics.", "authors": [{"family": "Lindahl", "given": "B I B", "initials": "BIB"}], "type": "journal article", "published": "2021-05-25", "journal": {"title": "Hist Philos Life Sci", "issn": "1742-6316", "volume": "43", "issue": "2", "pages": "72", "issn-l": null}, "abstract": "The World Health Organization has issued international instructions for certification and classification (coding) of the coronavirus disease (COVID-19) as cause of death. Central to these instructions is the selection of the underlying cause of death for a public health preventive purpose. This article focuses on two rules for this selection: (1) that a death due to COVID-19 should be counted independently of pre-existing conditions that are suspected of triggering a severe course of COVID-19 and (2) that COVID-19 should not be considered as due to anything else. The article argues that observance of the first rule may not always lead to an optimal selection from a preventive point of view and that in the future the ascertainment of an animal source of the coronavirus (SARS-CoV-2) would make it possible to reconceptualize 'COVID-19' and create a zoonotic classification code by means of which a factor of a greater preventive value could be selected than what is currently possible.", "doi": "10.1007/s40656-021-00420-8", "pmid": "34036448", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40656-021-00420-8"}], "notes": [], "created": "2021-05-29T15:33:59.474Z", "modified": "2021-05-29T15:33:59.496Z"}, {"entity": "publication", "iuid": "677b5b6503734ac8907936442131505a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/677b5b6503734ac8907936442131505a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/677b5b6503734ac8907936442131505a"}}, "title": "Urinary cytokines correlate with acute kidney injury in critically ill COVID-19 patients.", "authors": [{"family": "Gradin", "given": "A", "initials": "A"}, {"family": "Andersson", "given": "H", "initials": "H"}, {"family": "Luther", "given": "T", "initials": "T"}, {"family": "Anderberg", "given": "S B\u00fclow", "initials": "SB"}, {"family": "Rubertsson", "given": "S", "initials": "S"}, {"family": "Lipcsey", "given": "M", "initials": "M"}, {"family": "\u00c5berg", "given": "M", "initials": "M"}, {"family": "Larsson", "given": "A", "initials": "A"}, {"family": "Frithiof", "given": "R", "initials": "R"}, {"family": "Hultstr\u00f6m", "given": "M", "initials": "M"}], "type": "journal article", "published": "2021-05-24", "journal": {"title": "Cytokine", "issn": "1043-4666", "issn-l": null, "volume": "146", "issue": null, "pages": "155589"}, "abstract": "Acute kidney injury is common in COVID-19 patients admitted to the ICU. Urinary biomarkers are a non-invasive way of assaying renal damage, and so far, urinary cytokines are not fully investigated. The current study aimed to assess urinary cytokine levels in COVID-19 patients.\r\n\r\nUrine was collected from COVID-19 patients (n = 29) in intensive care and compared to a preoperative group of patients (n = 9) with no critical illness. 92 urinary cytokines were analyzed in multiplex using the Olink Target 96 inflammation panel and compared to clinical characteristics, and urinary markers of kidney injury.\r\n\r\nThere were strong correlations between proinflammatory cytokines and between urinary cytokines and urinary kidney injury markers in 29 COVID-19 patients. Several cytokines were correlated to kidney injury, 31 cytokines to AKI stage and 19 cytokines correlated to maximal creatinine.\r\n\r\nUrinary inflammatory cytokines from a wide range of immune cell lineages were significantly upregulated during COVID-19 and the upregulation correlated with acute kidney injury as well as urinary markers of kidney tissue damage.", "doi": "10.1016/j.cyto.2021.155589", "pmid": "34161857", "labels": {"Type: Journal article": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pii", "key": "S1043-4666(21)00172-1"}, {"db": "pmc", "key": "PMC8141692"}], "notes": [], "created": "2021-06-21T05:38:51.889Z", "modified": "2021-06-28T17:55:27.612Z"}, {"entity": "publication", "iuid": "fcc09b1d9efd444aae55abf8ed8b4e78", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fcc09b1d9efd444aae55abf8ed8b4e78.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fcc09b1d9efd444aae55abf8ed8b4e78"}}, "title": "Multiple sclerosis and COVID-19: The Swedish experience.", "authors": [{"family": "Landtblom", "given": "Anne-Marie", "initials": "AM"}, {"family": "Berntsson", "given": "Shala G", "initials": "SG"}, {"family": "Bostr\u00f6m", "given": "Inger", "initials": "I"}, {"family": "Iacobaeus", "given": "Ellen", "initials": "E"}], "type": "journal article", "published": "2021-05-24", "journal": {"title": "Acta Neurol Scand", "issn": "1600-0404", "volume": null, "issue": null, "issn-l": null}, "abstract": "The COVID-19 pandemic has brought challenges for healthcare management of patients with multiple sclerosis (MS). Concerns regarding vulnerability to infections and disease-modifying therapies (DMTs) and their complications have been raised. Recent published guidelines on the use of DMTs in relation to COVID-19 in MS patients have been diverse between countries with lack of evidence-based facts. In Sweden, there exists a particular interest in anti-CD20 therapy as a possible risk factor for severe COVID-19 due to the large number of rituximab-treated patients off-label in the country. Rapid responses from the Swedish MS Association (SMSS) and the Swedish MS registry (SMSreg) have resulted in national guidelines on DMT use for MS patients and implementation of a COVID-19 module in the SMSreg. Recently updated guidelines also included recommendations on COVID-19 vaccination with regard to the different DMTs. Social distancing policies forced implementation of telemedicine consultation to replace in-person consultations as part of regular MS health care. Patient-reported outcome measures (PROMs) in SMSreg have been useful in this respect. This paper reports our experiences on the progress of national MS health care during the COVID-19 pandemic, in addition to offering an overview of the present scientific context.", "doi": "10.1111/ane.13453", "pmid": "34028810", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-29T16:22:09.622Z", "modified": "2021-05-29T16:22:09.644Z"}, {"entity": "publication", "iuid": "45dbb9d073a14f418457c5550eb25254", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/45dbb9d073a14f418457c5550eb25254.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/45dbb9d073a14f418457c5550eb25254"}}, "title": "Hospital admission and mortality rates for non-covid diseases in Denmark during covid-19 pandemic: nationwide population based cohort study.", "authors": [{"family": "Bodilsen", "given": "Jacob", "initials": "J"}, {"family": "Nielsen", "given": "Peter Br\u00f8nnum", "initials": "PB"}, {"family": "S\u00f8gaard", "given": "Mette", "initials": "M"}, {"family": "Dalager-Pedersen", "given": "Michael", "initials": "M"}, {"family": "Speiser", "given": "Lasse Ole Zacho", "initials": "LOZ"}, {"family": "Yndigegn", "given": "Troels", "initials": "T"}, {"family": "Nielsen", "given": "Henrik", "initials": "H"}, {"family": "Larsen", "given": "Torben Bjerregaard", "initials": "TB"}, {"family": "Skj\u00f8th", "given": "Flemming", "initials": "F"}], "type": "journal article", "published": "2021-05-24", "journal": {"title": "BMJ", "issn": "1756-1833", "issn-l": null, "volume": "373", "issue": null, "pages": "n1135"}, "abstract": "To determine the incidence of hospital admissions and associated mortality rates for non-covid medical conditions during the covid-19 pandemic.\r\n\r\nNationwide, population based cohort study.\r\n\r\nDenmark from 13 March 2019 to 27 January 2021.\r\n\r\nAll Danish residents >1 year of age.\r\n\r\nPopulation based healthcare registries that encompass the entire Danish population were used to compare hospital admission and mortality rates during the covid-19 pandemic (from 11 March 2020 to 27 January 2021) with the prepandemic baseline data (from 13 March 2019 to 10 March 2020). Hospital admissions were categorised as covid-19 when patients were assigned a diagnosis code for covid-19 within five days of admission. All patients were followed until migration, death, or end of follow-up, whichever came first. Rate ratios for hospital admissions were computed using Poisson regression and were directly standardised using the Danish population on 1 January 2019 as reference. 30 day mortality rate ratios were examined by Cox regression, adjusted for age and sex, and covid-19 diagnosis was used as a competing risk.\r\n\r\n5 753 179 residents were identified during 567.8 million person weeks of observation, with 1 113 705 hospital admissions among 675 447 people. Compared with the prepandemic baseline period (mean hospital admission rate 204.1 per 100 000/week), the overall hospital admission rate for non-covid-19 conditions decreased to 142.8 per 100 000/week (rate ratio 0.70, 95% confidence interval 0.66 to 0.74) after the first national lockdown, followed by a gradual return to baseline levels until the second national lockdown when it decreased to 158.3 per 100 000/week (0.78, 0.73 to 0.82). This pattern was mirrored for most major diagnosis groups except for non-covid-19 respiratory diseases, nervous system diseases, cancer, heart failure, sepsis, and non-covid-19 respiratory infections, which remained lower throughout the study period. Overall 30 day mortality rates were higher during the first national lockdown (mortality rate ratio 1.28, 95% confidence interval 1.23 to 1.32) and the second national lockdown (1.20, 1.16 to 1.24), and these results were similar across most major diagnosis groups. For non-covid-19 respiratory diseases, cancer, pneumonia, and sepsis, the 30 day mortality rate ratios were also higher between lockdown periods.\r\n\r\nHospital admissions for all major non-covid-19 disease groups decreased during national lockdowns compared with the prepandemic baseline period. Additionally, mortality rates were higher overall and for patients admitted to hospital with conditions such as respiratory diseases, cancer, pneumonia, and sepsis. Increased attention towards management of serious non-covid-19 medical conditions is warranted.", "doi": "10.1136/bmj.n1135", "pmid": "34035000", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8142604"}], "notes": [], "created": "2021-05-29T15:40:08.762Z", "modified": "2021-07-14T09:02:41.329Z"}, {"entity": "publication", "iuid": "554af6363be444beb60516c49149884f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/554af6363be444beb60516c49149884f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/554af6363be444beb60516c49149884f"}}, "title": "Hematopoietic stem cell transplantation for autoimmune diseases in the time of COVID-19: EBMT guidelines and recommendations.", "authors": [{"family": "Greco", "given": "Raffaella", "initials": "R"}, {"family": "Alexander", "given": "Tobias", "initials": "T"}, {"family": "Burman", "given": "Joachim", "initials": "J"}, {"family": "Del Papa", "given": "Nicoletta", "initials": "N"}, {"family": "de Vries-Bouwstra", "given": "Jeska", "initials": "J"}, {"family": "Farge", "given": "Dominique", "initials": "D"}, {"family": "Henes", "given": "J\u00f6rg", "initials": "J"}, {"family": "Kazmi", "given": "Majid", "initials": "M"}, {"family": "Kirgizov", "given": "Kirill", "initials": "K"}, {"family": "Muraro", "given": "Paolo A", "initials": "PA"}, {"family": "Ricart", "given": "Elena", "initials": "E"}, {"family": "Rovira", "given": "Montserrat", "initials": "M"}, {"family": "Saccardi", "given": "Riccardo", "initials": "R"}, {"family": "Sharrack", "given": "Basil", "initials": "B"}, {"family": "Snarski", "given": "Emilian", "initials": "E"}, {"family": "Withers", "given": "Barbara", "initials": "B"}, {"family": "Jessop", "given": "Helen", "initials": "H"}, {"family": "Boglione", "given": "Claudia", "initials": "C"}, {"family": "Kramer", "given": "Ellen", "initials": "E"}, {"family": "Badoglio", "given": "Manuela", "initials": "M"}, {"family": "Labopin", "given": "Myriam", "initials": "M"}, {"family": "Orchard", "given": "Kim", "initials": "K"}, {"family": "Corbacioglu", "given": "Selim", "initials": "S"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Mikulska", "given": "Malgorzata", "initials": "M"}, {"family": "De la Camara", "given": "Rafael", "initials": "R"}, {"family": "Snowden", "given": "John A", "initials": "JA"}, {"family": "European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP), Infectious Diseases Working Party (IDWP), Pediatric Working Party (PWP), Joint Accreditation Committee of the International Society for Cellular Therapy (ISCT) and EBMT (JACIE), EBMT Nurses Group and Patient Advocacy Committee", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-24", "journal": {"title": "Bone Marrow Transplant", "issn": "1476-5365", "volume": null, "issue": null, "issn-l": "0268-3369"}, "abstract": "Coronavirus disease-19 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), represents one of the biggest challenges of 21st century, threatening public health around the globe. Increasing age and presence of co-morbidities are reported risk factors for severe disease and mortality, along with autoimmune diseases (ADs) and immunosuppressive treatments such as haematopoietic stem cell transplantation (HSCT), which are also associated with adverse outcomes. We review the impact of the pandemic on specific groups of patients with neurological, rheumatological, and gastroenterological indications, along with the challenges delivering HSCT in adult and pediatric populations. Moving forward, we developed consensus-based guidelines and recommendations for best practice and quality of patient care in order to support clinicians, scientists, and their multidisciplinary teams, as well as patients and their carers. These guidelines aim to support national and international organizations related to autoimmune diseases and local clinical teams delivering HSCT. Areas of unmet need and future research questions are also highlighted. The waves of the COVID-19 pandemic are predicted to be followed by an \"endemic\" phase and therefore an ongoing risk within a \"new normality\". These recommendations reflect currently available evidence, coupled with expert opinion, and will be revised according to necessary modifications in practice.", "doi": "10.1038/s41409-021-01326-6", "pmid": "34031556", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41409-021-01326-6"}, {"db": "pmc", "key": "PMC8143059"}], "notes": [], "created": "2021-05-29T15:41:52.441Z", "modified": "2021-05-29T15:41:52.450Z"}, {"entity": "publication", "iuid": "f9c19d1a5be34893afa3f5aba87ffb50", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f9c19d1a5be34893afa3f5aba87ffb50.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f9c19d1a5be34893afa3f5aba87ffb50"}}, "title": "Health care workers and migrant health: Pre- and post-COVID-19 considerations for reviewing and expanding the research agenda.", "authors": [{"family": "Gunn", "given": "Virginia", "initials": "V"}, {"family": "Somani", "given": "Rozina", "initials": "R"}, {"family": "Muntaner", "given": "Carles", "initials": "C"}], "type": "journal article", "published": "2021-05-24", "journal": {"title": "J Migr Health", "issn": "2666-6235", "volume": "4", "pages": "100048", "issn-l": null}, "abstract": "The main purpose of this article is to review several ways in which health care workers could either impact migrant health or be directly impacted by migration and, based on this, suggest the expansion of the current research agenda on migration and health to address a range of topics that are currently either neglected, insufficiently researched, or researched from different perspectives. To ground this suggestion and emphasize the complexity and significance of migrant health research, we start by briefly reviewing several migration-related notions including the process of migration and its key facilitators and benefits; existing barriers to the provision of migrant health care; and the intricate links between health systems, health professionals, and migrant health. The three areas of research examined in this article address (i) the specific role of health workers in providing care to migrants and refugees and their capacity to do so, (ii) the health problems experienced by health workers who become migrants or refugees, and (iii) the precarious employment conditions experienced by both migrant and non-migrant health care workers. After summarizing the current available evidence on these topics, we discuss key information gaps and strategies to address them, while also incorporating several relevant COVID-19 pandemic considerations and research implications. Expanding the focus of research studies on migration and health could not only enhance the results of current strategies by supplying additional information to support their implementation but also spearhead the development of new solutions to the migrant health problem.", "doi": "10.1016/j.jmh.2021.100048", "pmid": "34405193", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-6235(21)00015-5"}, {"db": "pmc", "key": "PMC8352207"}], "notes": [], "created": "2021-08-20T12:23:05.840Z", "modified": "2021-08-20T12:23:05.852Z"}, {"entity": "publication", "iuid": "cc8277510ec6494b9a70d5e7a955867b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc8277510ec6494b9a70d5e7a955867b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc8277510ec6494b9a70d5e7a955867b"}}, "title": "Challenges in PhD education due to COVID-19 - disrupted supervision or business as usual: a cross-sectional survey of Swedish biomedical sciences graduate students.", "authors": [{"family": "B\u00f6rgeson", "given": "Emma", "initials": "E"}, {"family": "Sotak", "given": "Matus", "initials": "M"}, {"family": "Kraft", "given": "Jamie", "initials": "J"}, {"family": "Bagunu", "given": "Grace", "initials": "G"}, {"family": "Bi\u00f6rserud", "given": "Christina", "initials": "C"}, {"family": "Lange", "given": "Stephan", "initials": "S"}], "type": "journal article", "published": "2021-05-22", "journal": {"title": "BMC Med Educ", "issn": "1472-6920", "volume": "21", "issue": "1", "pages": "294", "issn-l": null}, "abstract": "It remains unclear to what extent the SARS-CoV-2/COVID-19 pandemic disrupted the normal progression of biomedical and medical science graduate programs and if there was a lasting impact on the quality and quantity of supervision of PhD-students. To date, multiple editorials and commentaries indicate the severity of the disruption without providing sufficient evidence with quantifiable data.\n\nAn online survey was submitted to the administrative offices of biomedical and medical PhD-programs at eight major universities in Sweden to gauge the impact of the pandemic on the students. It consisted of multiple-choice and open-ended questions where students could provide examples of positive and/or negative supervision strategies. Open answered questions were coded as either examples of positive or negative support.\n\nPhD students were divided into two groups: those with improved or unchanged supervision during the pandemic (group 1, n = 185), versus those whose supervision worsened (group 2, n = 69). Group 1 received more help from supervisors and more frequent supervision via both online and alternative platforms (email/messages and telephone). There was no significant difference in educational-stage, gender or caretaking responsibilities between the groups.\n\nIt is important for the scientific community to learn how to provide the best possible supervision for PhD students during the pandemic. Our data suggests that more frequent supervision, and using a diverse array of meeting platforms is helpful. In addition, it is important for the students to feel that they have their supervisor's emotional support. Several students also expressed that they would benefit from an extension of their PhD programs due to delays caused by the pandemic.", "doi": "10.1186/s12909-021-02727-3", "pmid": "34022871", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12909-021-02727-3"}, {"db": "pmc", "key": "PMC8140581"}], "notes": [], "created": "2021-05-29T16:23:39.100Z", "modified": "2021-05-29T16:23:39.112Z"}, {"entity": "publication", "iuid": "56750c28d65e4a0c9e2f792150d25e4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56750c28d65e4a0c9e2f792150d25e4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56750c28d65e4a0c9e2f792150d25e4c"}}, "title": "Long term extracorporeal membrane oxygenation bridge to lung transplant after COVID-19.", "authors": [{"family": "Magnusson", "given": "Jesper M", "initials": "JM"}, {"family": "Silverborn", "given": "Martin", "initials": "M"}, {"family": "Broome", "given": "Michael", "initials": "M"}, {"family": "Riise", "given": "Gerdt C", "initials": "GC"}, {"family": "Dellgren", "given": "G\u00f6ran", "initials": "G"}], "type": "case reports", "published": "2021-05-21", "journal": {"title": "Ann Thorac Surg", "issn": "1552-6259", "volume": null, "issue": null, "issn-l": null}, "abstract": "We report a patient with acute respiratory syndrome coronavirus 2 infection and irreversible lung destruction who underwent successful lung transplantation after 138 days of bridging with extracorporeal membrane oxygenation support. The case exemplifies that lung transplantation might be a possibility after very long-term Coronavirus disease 2019 care, even if the patient is initially unsuitable. Patient consent was acquired before writing the case report.", "doi": "10.1016/j.athoracsur.2021.04.092", "pmid": "34029534", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0003-4975(21)00887-0"}, {"db": "pmc", "key": "PMC8139362"}], "notes": [], "created": "2021-05-29T16:20:44.248Z", "modified": "2021-05-29T16:20:59.683Z"}, {"entity": "publication", "iuid": "eb4ec86a74ce44358788f11c359b46b8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb4ec86a74ce44358788f11c359b46b8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb4ec86a74ce44358788f11c359b46b8"}}, "title": "Position statement of the international network for child and family centered care: Child and family centred care during the COVID19 pandemic.", "authors": [{"family": "Al-Motlaq", "given": "Mohammad", "initials": "M"}, {"family": "Neill", "given": "Sarah", "initials": "S"}, {"family": "Foster", "given": "Mandie Jane", "initials": "MJ"}, {"family": "Coyne", "given": "Imelda", "initials": "I"}, {"family": "Houghton", "given": "Davina", "initials": "D"}, {"family": "Angelhoff", "given": "Charlotte", "initials": "C"}, {"family": "Rising-Holmstr\u00f6m", "given": "Malin", "initials": "M"}, {"family": "Majamanda", "given": "Maureen", "initials": "M"}], "type": "journal article", "published": "2021-05-20", "journal": {"title": "J Pediatr Nurs", "issn": "1532-8449", "volume": "61", "issue": null, "pages": "140-143", "issn-l": null}, "abstract": "It is the position of the International Network for Child and Family Centered Care (INCFCC) that COVID19 restrictions pose tremendous challenges for the health care team in their efforts to provide child and family centered care (CFCC). COVID-19 restrictions impact on the family's right to be presernt with their ill child and to contribute to the caring process. A limited number of articles have discussed challenges about the successful delivery of CFCC during the COVID-19 pandemic. Based on current literature, the INCFCC stresses the need for continuous facilitation implementation of child and family centred care as, it is essential for children's physical and psychological wellbeing. Furthermore we believe that the families' presence and participation holds more benefits than risks to the health of children, their families, and the health care team.", "doi": "10.1016/j.pedn.2021.05.002", "pmid": "34052501", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0882-5963(21)00149-4"}], "notes": [], "created": "2021-05-31T16:10:04.873Z", "modified": "2021-05-31T16:10:04.890Z"}, {"entity": "publication", "iuid": "3b5d32446a3444ada161d4e85c38c33d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b5d32446a3444ada161d4e85c38c33d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b5d32446a3444ada161d4e85c38c33d"}}, "title": "Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice", "authors": [{"family": "De Gasparo", "given": "Raoul", "initials": "R"}, {"family": "Pedotti", "given": "Mattia", "initials": "M"}, {"family": "Simonelli", "given": "Luca", "initials": "L"}, {"family": "Nickl", "given": "Petr", "initials": "P", "orcid": "0000-0002-4289-0502", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd09e87cae524e40922a94720a978674.json"}}, {"family": "Muecksch", "given": "Frauke", "initials": "F", "orcid": "0000-0002-0132-5101", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94b175929ad14fec921e737bb3dceda7.json"}}, {"family": "Cassaniti", "given": "Irene", "initials": "I"}, {"family": "Percivalle", "given": "Elena", "initials": "E"}, {"family": "Lorenzi", "given": "Julio C C", "initials": "JCC"}, {"family": "Mazzola", "given": "Federica", "initials": "F"}, {"family": "Magr\u00ec", "given": "Davide", "initials": "D", "orcid": "0000-0003-3790-5332", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15cedaba7cb3438fad6c71e2a015921e.json"}}, {"family": "Michalcikova", "given": "Tereza", "initials": "T"}, {"family": "Haviernik", "given": "Jan", "initials": "J"}, {"family": "Honig", "given": "Vaclav", "initials": "V", "orcid": "0000-0003-0469-4604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65499eafa5a24320b87d2534f4dcf99a.json"}}, {"family": "Mrazkova", "given": "Blanka", "initials": "B"}, {"family": "Polakova", "given": "Natalie", "initials": "N"}, {"family": "Fortova", "given": "Andrea", "initials": "A"}, {"family": "Tureckova", "given": "Jolana", "initials": "J"}, {"family": "Iatsiuk", "given": "Veronika", "initials": "V"}, {"family": "Di Girolamo", "given": "Salvatore", "initials": "S"}, {"family": "Palus", "given": "Martin", "initials": "M"}, {"family": "Zudova", "given": "Dagmar", "initials": "D"}, {"family": "Bednar", "given": "Petr", "initials": "P"}, {"family": "Bukova", "given": "Ivana", "initials": "I"}, {"family": "Bianchini", "given": "Filippo", "initials": "F"}, {"family": "Mehn", "given": "Dora", "initials": "D"}, {"family": "Nencka", "given": "Radim", "initials": "R"}, {"family": "Strakova", "given": "Petra", "initials": "P"}, {"family": "Pavlis", "given": "Oto", "initials": "O"}, {"family": "Rozman", "given": "Jan", "initials": "J", "orcid": "0000-0002-8035-8904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/69dca82b58b8449c8af3e096813d6003.json"}}, {"family": "Gioria", "given": "Sabrina", "initials": "S"}, {"family": "Sammartino", "given": "Jos\u00e8 Camilla", "initials": "JC"}, {"family": "Giardina", "given": "Federica", "initials": "F"}, {"family": "Gaiarsa", "given": "Stefano", "initials": "S"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q", "orcid": "0000-0003-1990-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/94a32366862b470eba3a15521b9be290.json"}}, {"family": "Barnes", "given": "Christopher O", "initials": "CO"}, {"family": "Bjorkman", "given": "Pamela J", "initials": "PJ", "orcid": "0000-0002-2277-3990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/65549e18865046ac99cfee9f969c2759.json"}}, {"family": "Calzolai", "given": "Luigi", "initials": "L", "orcid": "0000-0002-8474-7974", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e3a67661994a48e28a8279fb27346285.json"}}, {"family": "Piralla", "given": "Antonio", "initials": "A", "orcid": "0000-0002-6062-2579", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/af56fb1bc11f43d9861faa71c5b50043.json"}}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Nussenzweig", "given": "Michel C", "initials": "MC"}, {"family": "Bieniasz", "given": "Paul D", "initials": "PD", "orcid": "0000-0002-2368-3719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72f7075120214d4091202cd80ffbe506.json"}}, {"family": "Hatziioannou", "given": "Theodora", "initials": "T"}, {"family": "Prochazka", "given": "Jan", "initials": "J"}, {"family": "Sedlacek", "given": "Radislav", "initials": "R", "orcid": "0000-0002-3352-392X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a1594084f604610a995def1f7a6bdb2.json"}}, {"family": "Robbiani", "given": "Davide F", "initials": "DF", "orcid": "0000-0001-7379-3484", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/941e237779f74a568228c6fe1ee8800c.json"}}, {"family": "Ruzek", "given": "Daniel", "initials": "D", "orcid": "0000-0003-4655-2380", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f49c5724719433ea99ebf38a4ff4a58.json"}}, {"family": "Varani", "given": "Luca", "initials": "L", "orcid": "0000-0002-0963-0987", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6c4a4cecfc04659b3b8df2b49430ba6.json"}}], "type": "journal-article", "published": "2021-05-20", "journal": {"title": "Nature", "issn": "0028-0836", "issn-l": null, "volume": "593", "issue": "7859", "pages": "424-428"}, "abstract": "Neutralizing antibodies targeting the receptor binding domain (RBD) of the SARS-CoV-2 Spike (S) are among the most promising approaches against coronavirus disease 2019 (COVID-19) 1,2 . We developed a bispecific, IgG1-like molecule based on two antibodies derived from COVID-19 convalescent donors, C121 and C135 3 . CoV-X2 simultaneously binds two independent sites on the RBD and, unlike its parental antibodies, completely prevents S binding to Angiotensin-Converting Enzyme 2 (ACE2), the virus cellular receptor. Furthermore, CoV-X2 recognizes a broad panel of RBD variants and neutralizes SARS-CoV-2 and the escape mutants generated by the single monoclonals at sub-nanomolar concentrations. In a novel model of SARS-CoV-2 infection with lung inflammation, CoV-X2 protects mice from disease and suppresses viral escape. Thus, simultaneous targeting of non-overlapping RBD epitopes by IgG-like bispecific antibodies is feasible and effective, combining into a single molecule the advantages of antibody cocktails.", "doi": "10.1038/s41586-021-03461-y", "pmid": "33501434", "labels": {"Category: Biochemistry": null, "Funder: H2020": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-18T11:10:09.811Z", "modified": "2021-06-18T11:01:30.134Z"}, {"entity": "publication", "iuid": "5e3db02127264d2e8c356e9bff7ad2dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e3db02127264d2e8c356e9bff7ad2dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e3db02127264d2e8c356e9bff7ad2dd"}}, "title": "Authors' Reply to: COVID-19 as a \"Force Majeure\" for Non-COVID-19 Clinical and Translational Research. Comment on \"Analysis of Scientific Publications During the Early Phase of the COVID-19 Pandemic: Topic Modeling Study\".", "authors": [{"family": "\u00c4lg\u00e5", "given": "Andreas", "initials": "A"}, {"family": "Eriksson", "given": "Oskar", "initials": "O"}, {"family": "Nordberg", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2021-05-20", "journal": {"title": "J Med Internet Res", "issn": "1438-8871", "volume": "23", "issue": "5", "pages": "e29156", "issn-l": null}, "abstract": null, "doi": "10.2196/29156", "pmid": "33989170", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "v23i5e29156"}], "notes": [], "created": "2021-05-21T17:02:08.259Z", "modified": "2021-05-21T17:03:39.189Z"}, {"entity": "publication", "iuid": "c3e66e3c5ab449bfb3c028254e5038fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3e66e3c5ab449bfb3c028254e5038fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3e66e3c5ab449bfb3c028254e5038fc"}}, "title": "Systematic Organization of COVID-19 Data Supported by the Adverse Outcome Pathway Framework.", "authors": [{"family": "Nymark", "given": "Penny", "initials": "P"}, {"family": "Sachana", "given": "Magdalini", "initials": "M"}, {"family": "Leite", "given": "Sofia Batista", "initials": "SB"}, {"family": "Sund", "given": "Jukka", "initials": "J"}, {"family": "Krebs", "given": "Catharine E", "initials": "CE"}, {"family": "Sullivan", "given": "Kristie", "initials": "K"}, {"family": "Edwards", "given": "Stephen", "initials": "S"}, {"family": "Viviani", "given": "Laura", "initials": "L"}, {"family": "Willett", "given": "Catherine", "initials": "C"}, {"family": "Landesmann", "given": "Brigitte", "initials": "B"}, {"family": "Wittwehr", "given": "Clemens", "initials": "C"}], "type": "journal article", "published": "2021-05-19", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "9", "issue": null, "pages": "638605"}, "abstract": "Adverse Outcome Pathways (AOP) provide structured frameworks for the systematic organization of research data and knowledge. The AOP framework follows a set of key principles that allow for broad application across diverse disciplines related to human health, including toxicology, pharmacology, virology and medical research. The COVID-19 pandemic engages a great number of scientists world-wide and data is increasing with exponential speed. Diligent data management strategies are employed but approaches for systematically organizing the data-derived information and knowledge are lacking. We believe AOPs can play an important role in improving interpretation and efficient application of scientific understanding of COVID-19. Here, we outline a newly initiated effort, the CIAO project (https://www.ciao-covid.net/), to streamline collaboration between scientists across the world toward development of AOPs for COVID-19, and describe the overarching aims of the effort, as well as the expected outcomes and research support that they will provide.", "doi": "10.3389/fpubh.2021.638605", "pmid": "34095051", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8170012"}], "notes": [], "created": "2021-06-08T08:49:30.261Z", "modified": "2021-06-08T08:53:33.409Z"}, {"entity": "publication", "iuid": "b4930e10644a4b13aa604f7263c2888b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b4930e10644a4b13aa604f7263c2888b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b4930e10644a4b13aa604f7263c2888b"}}, "title": "Social media for field epidemiologists (#SoMe4epis): How to use Twitter during the #COVID19 pandemic.", "authors": [{"family": "Hammer", "given": "Charlotte C", "initials": "CC"}, {"family": "Boender", "given": "T Sonia", "initials": "TS"}, {"family": "Thomas", "given": "Daniel Rh", "initials": "DR"}], "type": "journal article", "published": "2021-05-19", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic has fundamentally changed the way that public health professionals work and communicate. Over a very short time span, remote working arrangements have become the norm, and meetings have shifted online. Physical distancing measures have accelerated a trend toward digital communication and social exchange. At the same time, the work of epidemiologists has been held under a magnifying glass by journalists, governments and the general public, in a way not previously seen. As social media have become an inevitable part of our society over the last decade, Twitter has become a key communication tool and platform for social networking among epidemiologists (#EpiTwitter). In this article we reflect on the use of Twitter by field epidemiologists and public health microbiologists for rapid professional exchange, public communication of science, and professional development during the pandemic, as well as the associated risks. For those field epidemiologists new to social media, we discuss how Twitter can be used in a variety of ways, both at their home institutions and during field deployment. These include: information dissemination, science communication and public health advocacy, professional development, networking and experience exchange.", "doi": "10.1016/j.ijid.2021.05.035", "pmid": "34022332", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)00437-9"}], "notes": [], "created": "2021-05-29T16:24:31.698Z", "modified": "2022-11-22T05:47:08.310Z"}, {"entity": "publication", "iuid": "47be8642a1d3402f8d7f81aab73f8a34", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47be8642a1d3402f8d7f81aab73f8a34.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47be8642a1d3402f8d7f81aab73f8a34"}}, "title": "Gender and Entrepreneurship in Pandemic Time: What Demands and What Resources? An Exploratory Study.", "authors": [{"family": "De Simone", "given": "Silvia", "initials": "S"}, {"family": "Pileri", "given": "Jessica", "initials": "J"}, {"family": "Rapp-Ricciardi", "given": "Max", "initials": "M"}, {"family": "Barbieri", "given": "Barbara", "initials": "B"}], "type": "journal article", "published": "2021-05-19", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "issue": null, "pages": "668875", "issn-l": "1664-1078"}, "abstract": "Due to the coronavirus disease 2019 (COVID-19) epidemic, global economies have suffered an exogenous shock never seen before with a strong economic and psychosocial impact on organizations. Italy, in the context of the research, has been severely affected. The economic crisis has mainly affected women. In this scenario, entrepreneurial perceived success (objective and subjective) is influenced by increasingly burdensome job demands that entrepreneurs have to face up. Using the job demand-resources model, the study aims to broaden the knowledge of the determinants of entrepreneurial perceived success in the current emergency moment. In particular, as regards of the demands, alongside the specific entrepreneurial demands (time demands, uncertainty and risk, and responsibility), we also decided to include the negative interface family-work in both directions from-family-to-work (NEGWIF) and from-work-to-family (NEGFIW). Regarding the resources, we considered entrepreneurial self-efficacy (researching, planning, marshaling, implementing people, and implementing financial), proactive and elaborate social strategies (SS), and both directions of the positive interface: from-family-to-work (POSWIF) and from-work-to-family (POSFIW). All participants are women entrepreneurs ( N = 137) who have completed a self-report questionnaire. We explored the associations between demands, resources, and the dimensions of success through hierarchical regressions. As for the demands, time demands, uncertainty and risk, NEGWIF, and NEGFIW negatively influenced the perceived entrepreneurial success. Regarding resources, planning, implementing financial, proactive and elaborate SS positively influenced the perceived entrepreneurial success.", "doi": "10.3389/fpsyg.2021.668875", "pmid": "34093367", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8170095"}], "notes": [], "created": "2021-06-08T08:48:31.709Z", "modified": "2021-06-08T08:48:31.719Z"}, {"entity": "publication", "iuid": "2292c98cfe14465294b658610e6fc3a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2292c98cfe14465294b658610e6fc3a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2292c98cfe14465294b658610e6fc3a1"}}, "title": "A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection.", "authors": [{"family": "Miller", "given": "Ami", "initials": "A"}, {"family": "Leach", "given": "Adam", "initials": "A"}, {"family": "Thomas", "given": "Jemima", "initials": "J"}, {"family": "McAndrew", "given": "Craig", "initials": "C"}, {"family": "Bentley", "given": "Emma", "initials": "E"}, {"family": "Mattiuzzo", "given": "Giada", "initials": "G"}, {"family": "John", "given": "Lijo", "initials": "L"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Harris", "given": "Gemma", "initials": "G"}, {"family": "Gamage", "given": "Nadisha", "initials": "N"}, {"family": "Carr", "given": "Stephen", "initials": "S"}, {"family": "Ali", "given": "Hanif", "initials": "H"}, {"family": "Van Montfort", "given": "Rob", "initials": "R"}, {"family": "Rabbitts", "given": "Terence", "initials": "T"}], "type": "journal article", "published": "2021-05-19", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "10617", "issn-l": "2045-2322"}, "abstract": "Approaches are needed for therapy of the severe acute respiratory syndrome from SARS-CoV-2 coronavirus (COVID-19). Interfering with the interaction of viral antigens with the angiotensin converting enzyme 2 (ACE-2) receptor is a promising strategy by blocking the infection of the coronaviruses into human cells. We have implemented a novel protein engineering technology to produce a super-potent tetravalent form of ACE2, coupled to the human immunoglobulin \u03b31 Fc region, using a self-assembling, tetramerization domain from p53 protein. This high molecular weight Quad protein (ACE2-Fc-TD) retains binding to the SARS-CoV-2 receptor binding spike protein and can form a complex with the spike protein plus anti-viral antibodies. The ACE2-Fc-TD acts as a powerful decoy protein that out-performs soluble monomeric and dimeric ACE2 proteins and blocks both SARS-CoV-2 pseudovirus and SARS-CoV-2 virus infection with greatly enhanced efficacy. The ACE2 tetrameric protein complex promise to be important for development as decoy therapeutic proteins against COVID-19. In contrast to monoclonal antibodies, ACE2 decoy is unlikely to be affected by mutations in SARS-CoV-2 that are beginning to appear in variant forms. In addition, ACE2 multimeric proteins will be available as therapeutic proteins should new coronaviruses appear in the future because these are likely to interact with ACE2 receptor.", "doi": "10.1038/s41598-021-89957-z", "pmid": "34012108", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-89957-z"}], "notes": [], "created": "2021-05-21T17:17:53.522Z", "modified": "2021-05-21T17:19:09.667Z"}, {"entity": "publication", "iuid": "0d0890dfdb014f09ae619216e6d0d2a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d0890dfdb014f09ae619216e6d0d2a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d0890dfdb014f09ae619216e6d0d2a2"}}, "title": "Type-I interferon signatures in SARS-CoV-2 infected Huh7 cells.", "authors": [{"family": "Chen", "given": "Xi", "initials": "X"}, {"family": "Saccon", "given": "Elisa", "initials": "E"}, {"family": "Appelberg", "given": "K Sofia", "initials": "KS"}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "Rodriguez", "given": "Jimmy Esneider", "initials": "JE"}, {"family": "Vinhas", "given": "Beatriz S\u00e1", "initials": "BS"}, {"family": "Frisan", "given": "Teresa", "initials": "T"}, {"family": "V\u00e9gv\u00e1ri", "given": "\u00c1kos", "initials": "\u00c1"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}, {"family": "Gupta", "given": "Soham", "initials": "S"}], "type": "journal article", "published": "2021-05-18", "journal": {"title": "Cell Death Discov", "issn": "2058-7716", "issn-l": null, "volume": "7", "issue": "1", "pages": "114"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes Coronavirus disease 2019 (COVID-19) has caused a global health emergency. A key feature of COVID-19 is dysregulated interferon-response. Type-I interferon (IFN-I) is one of the earliest antiviral innate immune responses following viral infection and plays a significant role in the pathogenesis of SARS-CoV-2. In this study, using a proteomics-based approach, we identified that SARS-CoV-2 infection induces delayed and dysregulated IFN-I signaling in Huh7 cells. We demonstrate that SARS-CoV-2 is able to inhibit RIG-I mediated IFN-\u03b2 production. Our results also confirm the recent findings that IFN-I pretreatment is able to reduce the susceptibility of Huh7 cells to SARS-CoV-2, but not post-treatment. Moreover, senescent Huh7 cells, in spite of showing accentuated IFN-I response were more susceptible to SARS-CoV-2 infection, and the virus effectively inhibited IFIT1 in these cells. Finally, proteomic comparison between SARS-CoV-2, SARS-CoV, and MERS-CoV revealed a distinct differential regulatory signature of interferon-related proteins emphasizing that therapeutic strategies based on observations in SARS-CoV and MERS-CoV should be used with caution. Our findings provide a better understanding of SARS-CoV-2 regulation of cellular interferon response and a perspective on its use as a treatment. Investigation of different interferon-stimulated genes and their role in the inhibition of SARS-CoV-2 pathogenesis may direct novel antiviral strategies.", "doi": "10.1038/s41420-021-00487-z", "pmid": "34006825", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41420-021-00487-z"}, {"db": "URL", "key": "https://github.com/neogilab/COVID_IFN", "description": "Codes generated in analyzing the data"}, {"db": "URL", "key": "http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD023450", "description": "ProteomeXhanger Consortium, PXD023450"}], "notes": [], "created": "2021-05-20T14:42:46.846Z", "modified": "2021-06-04T14:47:25.536Z"}, {"entity": "publication", "iuid": "1ee5e839575a4c60a617878c3cab93bc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ee5e839575a4c60a617878c3cab93bc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ee5e839575a4c60a617878c3cab93bc"}}, "title": "Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers.", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Rosell", "given": "Axel", "initials": "A"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Mangsbo", "given": "Sara M", "initials": "SM"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2021-05-18", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484", "volume": "325", "issue": "19", "pages": "2015-2016"}, "abstract": "This cohort study describes COVID-19\u2013related symptoms persisting 8 months after SARS-CoV-2 infection among Swedish health care workers and self-reported effects of the residual symptoms on respondents\u2019 home, work, and social function.", "doi": "10.1001/jama.2021.5612", "pmid": "33825846", "labels": {"Category: Health": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC8027932"}, {"db": "pii", "key": "2778528"}], "notes": [], "created": "2021-04-09T09:00:37.481Z", "modified": "2023-01-13T13:26:19.203Z"}, {"entity": "publication", "iuid": "427d81e50b244080b398a3346744fcec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/427d81e50b244080b398a3346744fcec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/427d81e50b244080b398a3346744fcec"}}, "title": "Seropositivity in blood donors and pregnant women during the first year of SARS-CoV-2 transmission in Stockholm, Sweden.", "authors": [{"family": "Castro Dopico", "given": "X", "initials": "X"}, {"family": "Muschiol", "given": "S", "initials": "S"}, {"family": "Christian", "given": "M", "initials": "M"}, {"family": "Hanke", "given": "L", "initials": "L"}, {"family": "Sheward", "given": "D J", "initials": "DJ"}, {"family": "Grinberg", "given": "N F", "initials": "NF"}, {"family": "Rorbach", "given": "J", "initials": "J"}, {"family": "Bogdanovic", "given": "G", "initials": "G"}, {"family": "Mcinerney", "given": "G M", "initials": "GM"}, {"family": "Allander", "given": "T", "initials": "T"}, {"family": "Wallace", "given": "C", "initials": "C"}, {"family": "Murrell", "given": "B", "initials": "B"}, {"family": "Albert", "given": "J", "initials": "J"}, {"family": "Karlsson Hedestam", "given": "G B", "initials": "GB"}], "type": "journal article", "published": "2021-05-18", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "In Sweden, social restrictions to contain SARS-CoV-2 have primarily relied upon voluntary adherence to a set of recommendations. Strict lockdowns have not been enforced, potentially affecting viral dissemination. To understand the levels of past SARS-CoV-2 infection in the Stockholm population before the start of mass vaccinations, healthy blood donors and pregnant women (n = 5,100) were sampled at random between 14 March 2020 and 28 February 2021.\r\n\r\nIn this cross-sectional prospective study, otherwise-healthy blood donors (n = 2,600) and pregnant women (n = 2,500) were sampled for consecutive weeks (at four intervals) throughout the study period. Sera from all participants and a cohort of historical (negative) controls (n = 595) were screened for IgG responses against stabilized trimers of the SARS-CoV-2 spike (S) glycoprotein and the smaller receptor-binding domain (RBD). As a complement to standard analytical approaches, a probabilistic (cut-off independent) Bayesian framework that assigns likelihood of past infection was used to analyse data over time.\r\n\r\nHealthy participant samples were randomly selected from their respective pools through Karolinska University Hospital. The study was carried out in accordance with Swedish Ethical Review Authority: registration number 2020-01807.\r\n\r\nNo participants were symptomatic at sampling, and blood donors were all over the age of 18. No additional metadata were available from the participants.\r\n\r\nBlood donors and pregnant women showed a similar seroprevalence. After a steep rise at the start of the pandemic, the seroprevalence trajectory increased steadily in approach to the winter second wave of infections, approaching 15% of all individuals surveyed by 13 December 2020. By the end of February 2021, 19% of the population tested seropositive. Notably, 96% of seropositive healthy donors screened (n = 56) developed neutralizing antibody responses at titres comparable to or higher than those observed in clinical trials of SARS-CoV-2 spike mRNA vaccination, supporting that mild infection engenders a competent B-cell response.\r\n\r\nThese data indicate that in the first year since the start of community transmission, seropositivity levels in metropolitan in Stockholm had reached approximately one in five persons, providing important baseline seroprevalence information prior to the start of vaccination.", "doi": "10.1111/joim.13304", "pmid": "34008203", "labels": {"Type: Journal article": null, "Category: Serology": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-20T14:40:09.375Z", "modified": "2021-06-18T08:55:05.225Z"}, {"entity": "publication", "iuid": "acb58f22ba544e3986bb4e8945638319", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/acb58f22ba544e3986bb4e8945638319.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/acb58f22ba544e3986bb4e8945638319"}}, "title": "Living with an ever-present breathlessness: Women's experiences of living with chronic obstructive pulmonary disease stage III or IV.", "authors": [{"family": "Ekdahl", "given": "Ann", "initials": "A"}, {"family": "S\u00f6derberg", "given": "Siv", "initials": "S"}, {"family": "Rising-Holmstr\u00f6m", "given": "Malin", "initials": "M"}], "type": "journal article", "published": "2021-05-18", "journal": {"title": "Scand J Caring Sci", "issn": "1471-6712", "volume": null, "issue": null, "issn-l": null}, "abstract": "Living with chronic obstructive pulmonary disease stage III or IV has a major impact on a person's everyday life. This qualitative study focuses on women with chronic obstructive pulmonary disease stage III or IV.\n\nThe aim of this study was to describe women's experiences of living with chronic obstructive pulmonary disease stage III or IV.\n\nA purposive sample of fifteen women with chronic obstructive pulmonary disease stage III or IV participated in the study. Data were collected through individual semi-structured interviews that were subjected to qualitative content analysis.\n\nOne theme was identified, stabilizing an ever-present breathlessness by restoring strength, and three categories are as follows: managing a restricted everyday life as an expert of their illness, being afraid of contracting infections leading to suffocation and suffering and importance of continuous help and support from significant others and digital media. Breathlessness restricted women with chronic obstructive pulmonary disease, living with a body they have to wait for. Managing everyday life was adapted to their limited abilities and energy. This required detailed planning, good knowledge of their breathing and body. Women were afraid of contracting life-threatening infections that caused suffering, especially COVID-19. The fear leads to isolation and digital media was described as an important means of communication. Significant others gave support and help that was practical and emotional. Women with chronic obstructive pulmonary disease experienced lack of continuous help and support from healthcare professionals.\n\nStabilizing an ever-present breathlessness by restoring strength required women with chronic obstructive pulmonary disease stage III or IV to conduct detailed planning to manage everyday life. Being afraid of contracting infections and the consequences of suffocation had increased since the pandemic COVID-19 outbreak, which led to self-isolation and an inactive everyday life. To get help, support and socialize, women used digital media.", "doi": "10.1111/scs.12998", "pmid": "34008226", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-20T14:38:38.418Z", "modified": "2021-05-21T17:12:48.720Z"}, {"entity": "publication", "iuid": "0f2ef23eea074d47af6dfa8672fa32c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0f2ef23eea074d47af6dfa8672fa32c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0f2ef23eea074d47af6dfa8672fa32c5"}}, "title": "[Rare but potentially life-threatening - Multisystem inflammatory syndrome in adults - a case description].", "authors": [{"family": "Berntson", "given": "Lillemor", "initials": "L"}, {"family": "von Seth", "given": "Magnus", "initials": "M"}, {"family": "B\u00fclow Anderberg", "given": "Sara", "initials": "S"}, {"family": "\u00c5kerstr\u00f6m", "given": "Tobias", "initials": "T"}, {"family": "Kurland", "given": "Siri", "initials": "S"}], "type": "case reports", "published": "2021-05-17", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "118", "issue": null, "pages": null}, "abstract": "Multisystem inflammatory syndrome in adults, MIS-A, is a rare but severe post-covid-19 immunologic complication. The presentation is similar to Multisystem inflammatory syndrome in children, MIS-C. Both MIS-A/C are life-threatening immunologic syndromes characterized by hypotension, skin rashes, myocardial affection, coagulopathy and GI symptoms. Here we describe a case of MIS-A in a 35-year-old previously healthy female who, five weeks after a mild covid-19 infection, presented with a life-threatening immunological reaction. The patient made a swift recovery upon treatment with immunoglobulins, corticosteroids and an interleukin-1 receptor antagonist. We want to highlight the importance of immunological derangements following covid-19 infections in adults. We also present a treatment suggestion for MIS-A based on the management routine for MIS-C, which has been developed from international discussions and collaborations by pediatric rheumatologists in Sweden and around the world.", "doi": null, "pmid": "33999400", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "21084"}], "notes": [], "created": "2021-05-21T16:58:51.071Z", "modified": "2021-07-09T12:34:21.741Z"}, {"entity": "publication", "iuid": "8e377d87e6a14ef796a22a4cd6edc9a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e377d87e6a14ef796a22a4cd6edc9a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e377d87e6a14ef796a22a4cd6edc9a9"}}, "title": "Reorganisation of GP surgeries during the COVID-19 outbreak: analysis of guidelines from 15 countries.", "authors": [{"family": "Tsopra", "given": "Rosy", "initials": "R"}, {"family": "Frappe", "given": "Paul", "initials": "P"}, {"family": "Streit", "given": "Sven", "initials": "S"}, {"family": "Neves", "given": "Ana Luisa", "initials": "AL"}, {"family": "Honkoop", "given": "Persijn J", "initials": "PJ"}, {"family": "Espinosa-Gonzalez", "given": "Ana Belen", "initials": "AB"}, {"family": "Gero\u011flu", "given": "Berk", "initials": "B"}, {"family": "Jahr", "given": "Tobias", "initials": "T"}, {"family": "Lingner", "given": "Heidrun", "initials": "H"}, {"family": "Nessler", "given": "Katarzyna", "initials": "K"}, {"family": "Pesolillo", "given": "Gabriella", "initials": "G"}, {"family": "Sivertsen", "given": "\u00d8yvind Stople", "initials": "\u00d8S"}, {"family": "Thulesius", "given": "Hans", "initials": "H"}, {"family": "Zoitanu", "given": "Raluca", "initials": "R"}, {"family": "Burgun", "given": "Anita", "initials": "A"}, {"family": "Kinouani", "given": "Sh\u00e9razade", "initials": "S"}], "type": "journal article", "published": "2021-05-17", "journal": {"title": "BMC Fam Pract", "issn": "1471-2296", "volume": "22", "issue": "1", "pages": "96", "issn-l": null}, "abstract": "General practitioners (GPs) play a key role in managing the COVID-19 outbreak. However, they may encounter difficulties adapting their practices to the pandemic. We provide here an analysis of guidelines for the reorganisation of GP surgeries during the beginning of the pandemic from 15 countries.\n\nA network of GPs collaborated together in a three-step process: (i) identification of key recommendations of GP surgery reorganisation, according to WHO, CDC and health professional resources from health care facilities; (ii) collection of key recommendations included in the guidelines published in 15 countries; (iii) analysis, comparison and synthesis of the results.\n\nRecommendations for the reorganisation of GP surgeries of four types were identified: (i) reorganisation of GP consultations (cancelation of non-urgent consultations, follow-up via e-consultations), (ii) reorganisation of GP surgeries (area partitioning, visual alerts and signs, strict hygiene measures), (iii) reorganisation of medical examinations by GPs (equipment, hygiene, partial clinical examinations, patient education), (iv) reorganisation of GP staff (equipment, management, meetings, collaboration with the local community).\n\nWe provide here an analysis of guidelines for the reorganisation of GP surgeries during the beginning of the COVID-19 outbreak from 15 countries. These guidelines focus principally on clinical care, with less attention paid to staff management, and the area of epidemiological surveillance and research is largely neglected. The differences of guidelines between countries and the difficulty to apply them in routine care, highlight the need of advanced research in primary care. Thereby, primary care would be able to provide recommendations adapted to the real-world settings and with stronger evidence, which is especially necessary during pandemics.", "doi": "10.1186/s12875-021-01413-z", "pmid": "34000985", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12875-021-01413-z"}], "notes": [], "created": "2021-05-20T14:57:16.242Z", "modified": "2021-05-21T16:53:15.785Z"}, {"entity": "publication", "iuid": "d9f1933746cc4b67a5a451049cc1bf1a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d9f1933746cc4b67a5a451049cc1bf1a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d9f1933746cc4b67a5a451049cc1bf1a"}}, "title": "Interruption of cancer screening services due to COVID-19 pandemic: lessons from previous disasters.", "authors": [{"family": "Puricelli Perin", "given": "Douglas M", "initials": "DM"}, {"family": "Christensen", "given": "Tess", "initials": "T"}, {"family": "Bur\u00f3n", "given": "Andrea", "initials": "A"}, {"family": "Haas", "given": "Jennifer S", "initials": "JS"}, {"family": "Kamineni", "given": "Aruna", "initials": "A"}, {"family": "Pashayan", "given": "Nora", "initials": "N"}, {"family": "Rabeneck", "given": "Linda", "initials": "L"}, {"family": "Smith", "given": "Robert", "initials": "R"}, {"family": "Elfstr\u00f6m", "given": "Miriam", "initials": "M"}, {"family": "Broeders", "given": "Mireille J M", "initials": "MJM"}, {"family": "International Cancer Screening Network ICSN", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-17", "journal": {"title": "Prev Med Rep", "issn": "2211-3355", "volume": null, "issue": null, "pages": "101399", "issn-l": null}, "abstract": "To review the scientific literature seeking lessons for the COVID-19 era that could be learned from previous health services interruptions that affected the delivery of cancer screening services.\n\nA systematic search was conducted up to April 17, 2020, with no restrictions on language or dates and resulted in 385 articles. Two researchers independently assessed the list and discussed any disagreements. Once a consensus was achieved for each paper, those selected were included in the review.\n\nEleven articles were included. Three studies were based in Japan, two in the United States, one in South Korea, one in Denmark, and the remaining four offered a global perspective on interruptions in health services due to natural or human-caused disasters. No articles covered an interruption due to a pandemic. The main themes identified in the reviewed studies were coordination, communication, resource availability and patient follow-up.\n\nLessons learned applied to the context of COVID-19 are that coordination involving partners across the health sector is essential to optimize resources and resume services, making them more resilient while preparing for future interruptions. Communication with the general population about how COVID-19 has affected cancer screening, measures taken to mitigate it and safely re-establish screening services is recommended. Use of mobile health systems to reach patients who are not accessing services and the application of resource-stratified guidelines are important considerations. More research is needed to explore best strategies for suspending, resuming and sustaining cancer screening programs, and preparedness for future disruptions, adapted to diverse health care systems.", "doi": "10.1016/j.pmedr.2021.101399", "pmid": "34026465", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2211-3355(21)00089-9"}, {"db": "pmc", "key": "PMC8126519"}], "notes": [], "created": "2021-05-29T16:23:10.213Z", "modified": "2021-05-29T16:23:10.235Z"}, {"entity": "publication", "iuid": "c8c1fc225e9c47ccbc1e8ef4853d31b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c8c1fc225e9c47ccbc1e8ef4853d31b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c8c1fc225e9c47ccbc1e8ef4853d31b3"}}, "title": "Global effect of COVID-19 pandemic on physical activity, sedentary behaviour and sleep among 3- to 5-year-old children: a longitudinal study of 14 countries.", "authors": [{"family": "Okely", "given": "Anthony D", "initials": "AD"}, {"family": "Kariippanon", "given": "Katharina E", "initials": "KE"}, {"family": "Guan", "given": "Hongyan", "initials": "H"}, {"family": "Taylor", "given": "Ellie K", "initials": "EK"}, {"family": "Suesse", "given": "Thomas", "initials": "T"}, {"family": "Cross", "given": "Penny L", "initials": "PL"}, {"family": "Chong", "given": "Kar Hau", "initials": "KH"}, {"family": "Suherman", "given": "Adang", "initials": "A"}, {"family": "Turab", "given": "Ali", "initials": "A"}, {"family": "Staiano", "given": "Amanda E", "initials": "AE"}, {"family": "Ha", "given": "Amy S", "initials": "AS"}, {"family": "El Hamdouchi", "given": "Asmaa", "initials": "A"}, {"family": "Baig", "given": "Aqsa", "initials": "A"}, {"family": "Poh", "given": "Bee Koon", "initials": "BK"}, {"family": "Del Pozo-Cruz", "given": "Borja", "initials": "B"}, {"family": "Chan", "given": "Cecilia H S", "initials": "CHS"}, {"family": "Nystr\u00f6m", "given": "Christine Delisle", "initials": "CD"}, {"family": "Koh", "given": "Denise", "initials": "D"}, {"family": "Webster", "given": "E Kipling", "initials": "EK"}, {"family": "Lubree", "given": "Himangi", "initials": "H"}, {"family": "Tang", "given": "Hong Kim", "initials": "HK"}, {"family": "Baddou", "given": "Issad", "initials": "I"}, {"family": "Del Pozo-Cruz", "given": "Jesus", "initials": "J"}, {"family": "Wong", "given": "Jyh Eiin", "initials": "JE"}, {"family": "Sultoni", "given": "Kuston", "initials": "K"}, {"family": "Nacher", "given": "Maria", "initials": "M"}, {"family": "L\u00f6f", "given": "Marie", "initials": "M"}, {"family": "Cui", "given": "Mingming", "initials": "M"}, {"family": "Hossain", "given": "Mohammad Sorowar", "initials": "MS"}, {"family": "Chathurangana", "given": "P W Prasad", "initials": "PWP"}, {"family": "Kand", "given": "Uddhavi", "initials": "U"}, {"family": "Wickramasinghe", "given": "V P Pujitha", "initials": "VPP"}, {"family": "Calleia", "given": "Rebecca", "initials": "R"}, {"family": "Ferdous", "given": "Shameema", "initials": "S"}, {"family": "Van Kim", "given": "Thanh", "initials": "T"}, {"family": "Wang", "given": "Xiaojuan", "initials": "X"}, {"family": "Draper", "given": "Catherine E", "initials": "CE"}], "type": "journal article", "published": "2021-05-17", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "940"}, "abstract": "The restrictions associated with the 2020 COVID-19 pandemic has resulted in changes to young children's daily routines and habits. The impact on their participation in movement behaviours (physical activity, sedentary screen time and sleep) is unknown. This international longitudinal study compared young children's movement behaviours before and during the COVID-19 pandemic.\r\n\r\nParents of children aged 3-5 years, from 14 countries (8 low- and middle-income countries, LMICs) completed surveys to assess changes in movement behaviours and how these changes were associated with the COVID-19 pandemic. Surveys were completed in the 12 months up to March 2020 and again between May and June 2020 (at the height of restrictions). Physical activity (PA), sedentary screen time (SST) and sleep were assessed via parent survey. At Time 2, COVID-19 factors including level of restriction, environmental conditions, and parental stress were measured. Compliance with the World Health Organizations (WHO) Global guidelines for PA (180 min/day [\u226560 min moderate- vigorous PA]), SST (\u22641 h/day) and sleep (10-13 h/day) for children under 5 years of age, was determined.\r\n\r\nNine hundred- forty-eight parents completed the survey at both time points. Children from LMICs were more likely to meet the PA (Adjusted Odds Ratio [AdjOR] = 2.0, 95%Confidence Interval [CI] 1.0,3.8) and SST (AdjOR = 2.2, 95%CI 1.2,3.9) guidelines than their high-income country (HIC) counterparts. Children who could go outside during COVID-19 were more likely to meet all WHO Global guidelines (AdjOR = 3.3, 95%CI 1.1,9.8) than those who were not. Children of parents with higher compared to lower stress were less likely to meet all three guidelines (AdjOR = 0.5, 95%CI 0.3,0.9).\r\n\r\nPA and SST levels of children from LMICs have been less impacted by COVID-19 than in HICs. Ensuring children can access an outdoor space, and supporting parents' mental health are important prerequisites for enabling pre-schoolers to practice healthy movement behaviours and meet the Global guidelines.", "doi": "10.1186/s12889-021-10852-3", "pmid": "34001086", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-10852-3"}], "notes": [], "created": "2021-05-20T14:51:42.291Z", "modified": "2021-07-14T08:56:13.805Z"}, {"entity": "publication", "iuid": "d83d23d7494d4c23a2587957eff51f2e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d83d23d7494d4c23a2587957eff51f2e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d83d23d7494d4c23a2587957eff51f2e"}}, "title": "Biomimetics provides lessons from nature for contemporary ways to improve human health.", "authors": [{"family": "Stenvinkel", "given": "Peter", "initials": "P"}, {"family": "Avesani", "given": "Carla M", "initials": "CM"}, {"family": "Gordon", "given": "Line J", "initials": "LJ"}, {"family": "Schalling", "given": "Martin", "initials": "M"}, {"family": "Shiels", "given": "Paul G", "initials": "PG"}], "type": "journal article", "published": "2021-05-17", "journal": {"title": "J Clin Transl Sci", "issn": "2059-8661", "volume": "5", "issue": "1", "pages": "e128", "issn-l": null}, "abstract": "Homo sapiens is currently living in serious disharmony with the rest of the natural world. For our species to survive, and for our well-being, we must gather knowledge from multiple perspectives and actively engage in studies of planetary health. The enormous diversity of species, one of the most striking aspects of life on our planet, provides a source of solutions that have been developed through evolution by natural selection by animals living in extreme environments. The food system is central to finding solutions; our current global eating patterns have a negative impact on human health, driven climate change and loss of biodiversity. We propose that the use of solutions derived from nature, an approach termed biomimetics, could mitigate the effects of a changing climate on planetary health as well as human health. For example, activation of the transcription factor Nrf2 may play a role in protecting animals living in extreme environments, or animals exposed to heat stress, pollution and pesticides. In order to meet these challenges, we call for the creation of novel interdisciplinary planetary health research teams.", "doi": "10.1017/cts.2021.790", "pmid": "34367673", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2059866121007901"}, {"db": "pmc", "key": "PMC8327543"}], "notes": [], "created": "2021-08-11T14:34:37.080Z", "modified": "2021-08-11T14:34:37.104Z"}, {"entity": "publication", "iuid": "8904e683c1844c42b5b8b5312843711d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8904e683c1844c42b5b8b5312843711d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8904e683c1844c42b5b8b5312843711d"}}, "title": "Antiviral Activity of Silver, Copper Oxide and Zinc Oxide Nanoparticle Coatings against SARS-CoV-2.", "authors": [{"family": "Merkl", "given": "Padryk", "initials": "P"}, {"family": "Long", "given": "Siwen", "initials": "S"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}, {"family": "Sotiriou", "given": "Georgios A", "initials": "GA"}], "type": "journal article", "published": "2021-05-17", "journal": {"title": "Nanomaterials (Basel)", "issn": "2079-4991", "issn-l": null, "volume": "11", "issue": "5", "pages": null}, "abstract": "SARS-CoV-2 is responsible for several million deaths to date globally, and both fomite transmission from surfaces as well as airborne transmission from aerosols may be largely responsible for the spread of the virus. Here, nanoparticle coatings of three antimicrobial materials (Ag, CuO and ZnO) are deposited on both solid flat surfaces as well as porous filter media, and their activity against SARS-CoV-2 viability is compared with a viral plaque assay. These nanocoatings are manufactured by aerosol nanoparticle self-assembly during their flame synthesis. Nanosilver particles as a coating exhibit the strongest antiviral activity of the three studied nanomaterials, while copper oxide exhibits moderate activity, and zinc oxide does not appear to significantly reduce the virus infectivity. Thus, nanosilver and copper oxide show potential as antiviral coatings on solid surfaces and on filter media to minimize transmission and super-spreading events while also providing critical information for the current and any future pandemic mitigation efforts.", "doi": "10.3390/nano11051312", "pmid": "34067553", "labels": {"Type: Journal article": null, "Funder: H2020": null, "Funder: VR": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "nano11051312"}], "notes": [], "created": "2021-06-04T11:20:05.272Z", "modified": "2021-08-25T14:33:10.797Z"}, {"entity": "publication", "iuid": "88dc506deffe4af0bf0684e37850a9a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/88dc506deffe4af0bf0684e37850a9a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/88dc506deffe4af0bf0684e37850a9a1"}}, "title": "Evaluation of SARS-CoV-2 rapid antigen diagnostic tests for saliva samples", "authors": [{"family": "Hagbom", "given": "Marie", "initials": "M"}, {"family": "Carmona-Vicente", "given": "Noelia", "initials": "N"}, {"family": "Sharma", "given": "Sumit", "initials": "S"}, {"family": "Olsson", "given": "Henrik", "initials": "H"}, {"family": "J\u00e4mtberg", "given": "Mikael", "initials": "M"}, {"family": "Nilsdotter-Augustinsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Sj\u00f6wall", "given": "Johanna", "initials": "J"}, {"family": "Nordgren", "given": "Johan", "initials": "J"}], "type": "posted-content", "published": "2021-05-16", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.05.14.21257100", "pmid": null, "labels": {"Type: Preprint": null, "Category: Serology": null}, "xrefs": [], "notes": [], "created": "2021-05-17T19:12:07.448Z", "modified": "2021-05-18T08:00:44.306Z"}, {"entity": "publication", "iuid": "a3d7ea4ae85740d18514f0d6cce89c17", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3d7ea4ae85740d18514f0d6cce89c17.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3d7ea4ae85740d18514f0d6cce89c17"}}, "title": "Worldwide Early Impact of COVID-19 on Dialysis Patients and Staff and Lessons Learned: A DOPPS Roundtable Discussion.", "authors": [{"family": "Robinson", "given": "Bruce M", "initials": "BM"}, {"family": "Guedes", "given": "Murilo", "initials": "M"}, {"family": "Alghonaim", "given": "Mohammed", "initials": "M"}, {"family": "Cases", "given": "Aleix", "initials": "A"}, {"family": "Dasgupta", "given": "Indranil", "initials": "I"}, {"family": "Gan", "given": "Liangying", "initials": "L"}, {"family": "Jacobson", "given": "Stefan H", "initials": "SH"}, {"family": "Kanjanabuch", "given": "Talerngsak", "initials": "T"}, {"family": "Kim", "given": "Yong-Lim", "initials": "YL"}, {"family": "Kleophas", "given": "Werner", "initials": "W"}, {"family": "Labriola", "given": "Laura", "initials": "L"}, {"family": "Perlman", "given": "Rachel L", "initials": "RL"}, {"family": "Reboldi", "given": "Gianpaolo", "initials": "G"}, {"family": "Srivatana", "given": "Vesh", "initials": "V"}, {"family": "Suri", "given": "Rita S", "initials": "RS"}, {"family": "Tsuruya", "given": "Kazuhiko", "initials": "K"}, {"family": "Torres", "given": "Pablo Urena", "initials": "PU"}, {"family": "Pisoni", "given": "Ronald L", "initials": "RL"}, {"family": "Pecoits-Filho", "given": "Roberto", "initials": "R"}], "type": "journal article", "published": "2021-05-14", "journal": {"title": "Kidney Med", "issn": "2590-0595", "volume": null, "issue": null, "issn-l": null}, "abstract": "As the worst global pandemic of the past century, COVID-19 has had a disproportionate effect on maintenance dialysis patients and their health care providers. At a virtual roundtable on 12 June 2020, DOPPS investigators from fifteen countries in Asia, Europe, and the Americas described and compared the effects of COVID-19 on dialysis care, with recent updates added. Most striking is the huge difference in risk to dialysis patients and staff across the world. Per-population cases and deaths among dialysis patients vary over 100-fold across participating countries, mirroring burden in the general population. International data indicate case fatality ratio remains at 10-30% among dialysis patients, confirming the gravity of infection, and that cases are much more common among in-center than home dialysis patients. This latter finding merits urgent study because in-center patients often have greater community exposure, and in-center transmission may be uncommon under optimal protocols. Greater telemedicine use is a welcome change here to stay, and our community needs to improve emergency planning and protect dialysis staff from the next pandemic. Finally, the pandemic's challenges have prompted widespread partnering and innovation in kidney care and research that must be sustained after this global health crisis.", "doi": "10.1016/j.xkme.2021.03.006", "pmid": "34007963", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2590-0595(21)00094-7"}, {"db": "pmc", "key": "PMC8120787"}], "notes": [], "created": "2021-05-20T14:41:36.932Z", "modified": "2021-05-21T17:15:11.990Z"}, {"entity": "publication", "iuid": "344e674e29bf4ea2a231789151621751", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/344e674e29bf4ea2a231789151621751.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/344e674e29bf4ea2a231789151621751"}}, "title": "Disease surveillance for the COVID-19 era: time for bold changes.", "authors": [{"family": "Morgan", "given": "Oliver W", "initials": "OW"}, {"family": "Aguilera", "given": "Ximena", "initials": "X"}, {"family": "Ammon", "given": "Andrea", "initials": "A"}, {"family": "Amuasi", "given": "John", "initials": "J"}, {"family": "Fall", "given": "Ibrahima Soc\u00e9", "initials": "IS"}, {"family": "Frieden", "given": "Tom", "initials": "T"}, {"family": "Heymann", "given": "David", "initials": "D"}, {"family": "Ihekweazu", "given": "Chikwe", "initials": "C"}, {"family": "Jeong", "given": "Eun-Kyeong", "initials": "EK"}, {"family": "Leung", "given": "Gabriel M", "initials": "GM"}, {"family": "Mahon", "given": "Barbara", "initials": "B"}, {"family": "Nkengasong", "given": "John", "initials": "J"}, {"family": "Qamar", "given": "Farah Naz", "initials": "FN"}, {"family": "Schuchat", "given": "Anne", "initials": "A"}, {"family": "Wieler", "given": "Lothar H", "initials": "LH"}, {"family": "Dowell", "given": "Scott F", "initials": "SF"}], "type": "journal article", "published": "2021-05-14", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": null, "issue": null, "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(21)01096-5", "pmid": "34000258", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)01096-5"}, {"db": "pmc", "key": "PMC8121493"}], "notes": [], "created": "2021-05-21T16:57:57.411Z", "modified": "2021-05-21T16:57:57.422Z"}, {"entity": "publication", "iuid": "7f250fa51c5b4cf3bb2120dd63e64434", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f250fa51c5b4cf3bb2120dd63e64434.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f250fa51c5b4cf3bb2120dd63e64434"}}, "title": "Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials.", "authors": [{"family": "Axfors", "given": "Cathrine", "initials": "C"}, {"family": "Schmitt", "given": "Andreas M", "initials": "AM", "orcid": "0000-0002-9568-8164", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e04ff63fee604c08bb913012e4645bf6.json"}}, {"family": "Janiaud", "given": "Perrine", "initials": "P"}, {"family": "Van't Hooft", "given": "Janneke", "initials": "J", "orcid": "0000-0001-5303-1503", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d0cd2d5d4ae4c88bf5b3307e32869a8.json"}}, {"family": "Abd-Elsalam", "given": "Sherief", "initials": "S", "orcid": "0000-0003-4366-2218", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fb051b677594bbca20b5637fc0420a9.json"}}, {"family": "Abdo", "given": "Ehab F", "initials": "EF", "orcid": "0000-0002-9805-3850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04cb35857c4b46829ebb73f25fad291a.json"}}, {"family": "Abella", "given": "Benjamin S", "initials": "BS", "orcid": "0000-0003-2521-0891", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7572ea9966aa4951afd5d2490960148e.json"}}, {"family": "Akram", "given": "Javed", "initials": "J"}, {"family": "Amaravadi", "given": "Ravi K", "initials": "RK"}, {"family": "Angus", "given": "Derek C", "initials": "DC"}, {"family": "Arabi", "given": "Yaseen M", "initials": "YM"}, {"family": "Azhar", "given": "Shehnoor", "initials": "S"}, {"family": "Baden", "given": "Lindsey R", "initials": "LR"}, {"family": "Baker", "given": "Arthur W", "initials": "AW", "orcid": "0000-0002-0914-0291", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51dd5ed5fb784143955e3c7e587b7014.json"}}, {"family": "Belkhir", "given": "Leila", "initials": "L"}, {"family": "Benfield", "given": "Thomas", "initials": "T", "orcid": "0000-0003-0698-9385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a335d1a321c46b2a0ba4f80dc3d93b4.json"}}, {"family": "Berrevoets", "given": "Marvin A H", "initials": "MAH"}, {"family": "Chen", "given": "Cheng-Pin", "initials": "CP", "orcid": "0000-0002-0629-9790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/773f850e035a47269048204713babe5f.json"}}, {"family": "Chen", "given": "Tsung-Chia", "initials": "TC", "orcid": "0000-0002-3461-5535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2df09990f13243b6a7d586e65808f9a5.json"}}, {"family": "Cheng", "given": "Shu-Hsing", "initials": "SH", "orcid": "0000-0002-6256-0527", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44efc129a6a54e9a85422a2c1122c047.json"}}, {"family": "Cheng", "given": "Chien-Yu", "initials": "CY"}, {"family": "Chung", "given": "Wei-Sheng", "initials": "WS", "orcid": "0000-0003-4240-5690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79973df7d6b94b529a779c7b3d1bc471.json"}}, {"family": "Cohen", "given": "Yehuda Z", "initials": "YZ", "orcid": "0000-0001-6987-1478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3839874cc0f4a91a69d0fb2fc15c35a.json"}}, {"family": "Cowan", "given": "Lisa N", "initials": "LN"}, {"family": "Dalgard", "given": "Olav", "initials": "O"}, {"family": "de Almeida E Val", "given": "Fernando F", "initials": "FF"}, {"family": "de Lacerda", "given": "Marcus V G", "initials": "MVG", "orcid": "0000-0003-3374-9985", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5df56fcaab5d4fbea3ee4a973b3ed44f.json"}}, {"family": "de Melo", "given": "Gisely C", "initials": "GC"}, {"family": "Derde", "given": "Lennie", "initials": "L", "orcid": "0000-0002-3577-5629", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cdd814a355e486a88cb134b060427bc.json"}}, {"family": "Dubee", "given": "Vincent", "initials": "V", "orcid": "0000-0002-9982-4741", "researcher": {"href": 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"given": "Ronghua", "initials": "R"}, {"family": "Jurado-Camacho", "given": "Felipe", "initials": "F"}, {"family": "Khan", "given": "Khalid S", "initials": "KS"}, {"family": "Kremsner", "given": "Peter G", "initials": "PG"}, {"family": "Kreuels", "given": "Benno", "initials": "B", "orcid": "0000-0003-2315-8954", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/752c98a06cbb43f9b5b8bf63127dd654.json"}}, {"family": "Kuo", "given": "Cheng-Yu", "initials": "CY"}, {"family": "Le", "given": "Thuy", "initials": "T", "orcid": "0000-0002-3393-6580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2380b23c0d1f423aa831d72279980706.json"}}, {"family": "Lin", "given": "Yi-Chun", "initials": "YC"}, {"family": "Lin", "given": "Wu-Pu", "initials": "WP", "orcid": "0000-0002-4206-7882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86d19e5169de4a139c6508eb7bd1e085.json"}}, {"family": "Lin", "given": "Tse-Hung", "initials": "TH"}, {"family": "Lyngbakken", "given": "Magnus Nakrem", "initials": "MN", "orcid": "0000-0002-5994-9304", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70c443e4d3674615bf090ed3b0d39e98.json"}}, {"family": "McArthur", "given": "Colin", "initials": "C"}, {"family": "McVerry", "given": "Bryan J", "initials": "BJ", "orcid": "0000-0002-1175-4874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/941d8c555b224fb18d897e9201d42f35.json"}}, {"family": "Meza-Meneses", "given": "Patricia", "initials": "P", "orcid": "0000-0002-3931-3114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be8220f4a58244838e2252f67c3ea28b.json"}}, {"family": "Monteiro", "given": "Wuelton M", "initials": "WM"}, {"family": "Morpeth", "given": "Susan C", "initials": "SC"}, {"family": "Mourad", "given": "Ahmad", "initials": "A", "orcid": "0000-0002-3149-597X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3323fc32cf4e44b2b677b838954f86aa.json"}}, {"family": "Mulligan", "given": "Mark J", "initials": "MJ"}, {"family": "Murthy", "given": "Srinivas", "initials": "S"}, {"family": "Naggie", "given": "Susanna", "initials": "S"}, {"family": "Narayanasamy", "given": "Shanti", "initials": "S", "orcid": "0000-0002-6667-2868", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53cc5ca9db8d49678370dbaad3d91ac0.json"}}, {"family": "Nichol", "given": "Alistair", "initials": "A"}, {"family": "Novack", "given": "Lewis A", "initials": "LA"}, {"family": "O'Brien", "given": "Sean M", "initials": "SM"}, {"family": "Okeke", "given": "Nwora Lance", "initials": "NL"}, {"family": "Perez", "given": "L\u00e9na", "initials": "L"}, {"family": "Perez-Padilla", "given": "Rogelio", "initials": "R"}, {"family": "Perrin", "given": "Laurent", "initials": "L", "orcid": "0000-0002-1916-6639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bdac388f14a404aa6a02e69083181fb.json"}}, {"family": "Remigio-Luna", "given": "Arantxa", "initials": "A"}, {"family": "Rivera-Martinez", "given": "Norma E", "initials": "NE", "orcid": "0000-0002-6716-1234", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0214c04c5d94f0082f9068398ab6e37.json"}}, {"family": "Rockhold", "given": "Frank W", "initials": "FW", "orcid": "0000-0003-3732-4765", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/409f57f9cdcd46f7bac6c309f50f6673.json"}}, {"family": "Rodriguez-Llamazares", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-7864-8953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76eb08936ea3405eb020251713f28c3d.json"}}, {"family": "Rolfe", "given": "Robert", "initials": "R"}, {"family": "Rosa", "given": "Rossana", "initials": "R"}, {"family": "R\u00f8sj\u00f8", "given": "Helge", "initials": "H"}, {"family": "Sampaio", "given": "Vanderson S", "initials": "VS", "orcid": "0000-0001-7307-8851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/934ee588c764416998481a7dbe4aad3e.json"}}, {"family": "Seto", "given": "Todd B", "initials": "TB"}, {"family": "Shahzad", "given": "Muhammad", "initials": "M"}, {"family": "Soliman", "given": "Shaimaa", "initials": "S"}, {"family": "Stout", "given": "Jason E", "initials": "JE", "orcid": "0000-0002-6698-8176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45ca2262503a439db34471f94f65aa11.json"}}, {"family": "Thirion-Romero", "given": "Ireri", "initials": "I"}, {"family": "Troxel", "given": "Andrea B", "initials": "AB"}, {"family": "Tseng", "given": "Ting-Yu", "initials": "TY"}, {"family": "Turner", "given": "Nicholas A", "initials": "NA", "orcid": "0000-0003-0650-4894", "researcher": {"href": 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"https://publications-covid19.scilifelab.se/researcher/f6d3264c064a4675bdbde7937711265c.json"}}, {"family": "Zhong", "given": "Wu", "initials": "W", "orcid": "0000-0002-0536-620X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8058cd239379403195b1cd7d9b5ca689.json"}}, {"family": "Moher", "given": "David", "initials": "D", "orcid": "0000-0003-2434-4206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/765e99136e2943c7a7f4ce4ed5848ff9.json"}}, {"family": "Goodman", "given": "Steven N", "initials": "SN"}, {"family": "Ioannidis", "given": "John P A", "initials": "JPA", "orcid": "0000-0003-3118-6859", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9844ea41bc554157a721820d7986a442.json"}}, {"family": "Hemkens", "given": "Lars G", "initials": "LG", "orcid": "0000-0002-3444-1432", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b2562d656a74e7d91427b55ca667784.json"}}], "type": "published erratum", "published": "2021-05-14", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "3001", "issn-l": "2041-1723"}, "abstract": null, "doi": "10.1038/s41467-021-23559-1", "pmid": "33990619", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8121133"}, {"db": "pii", "key": "10.1038/s41467-021-23559-1"}], "notes": [], "created": "2021-05-17T18:41:37.862Z", "modified": "2023-06-19T15:39:56.966Z"}, {"entity": "publication", "iuid": "26c86085b9c84f40a35b66cd590454f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26c86085b9c84f40a35b66cd590454f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26c86085b9c84f40a35b66cd590454f8"}}, "title": "Changes in Availability, Utilization, and Prices of Medicines and Protection Equipment for COVID-19 in an Urban Population of Northern Nigeria.", "authors": [{"family": "Haque", "given": "Mainul", "initials": "M"}, {"family": "Abubakar", "given": "Abdullahi Rabiu", "initials": "AR"}, {"family": "Ogunleye", "given": "Olayinka O", "initials": "OO"}, {"family": "Sani", "given": "Ibrahim Haruna", "initials": "IH"}, {"family": "Sefah", "given": "Israel", "initials": "I"}, {"family": "Kurdi", "given": "Amanj", "initials": "A"}, {"family": "Islam", "given": "Salequl", "initials": "S"}, {"family": "Godman", "given": "Brian", "initials": "B"}], "type": "journal article", "published": "2021-05-13", "journal": {"title": "J Res Pharm Pract", "issn": "2319-9644", "volume": "10", "issue": "1", "pages": "17-22", "issn-l": null}, "abstract": "Measures are ongoing to prevent the spread of COVID-19 and treat it with medicines and personal protective equipment (PPE). However, there has been considerable controversy surrounding treatments such as hydroxychloroquine with misinformation fuelling prices hikes and suicides. Shortages have also appreciably increased costs of PPE, potentially catastrophic among lower- and middle-income countries such as Nigeria with high copayment levels. Consequently, a need to investigate changes in availability, utilization, and prices of relevant medicines and PPE during the pandemic in Nigeria.\n\nExploratory study among community pharmacists with a survey tool comprising four sections including questions on changes in consumption, prices, and shortages of medicines and PPE from the beginning of March 2020 to the end of June 2020. In addition, suggestions from community pharmacists and co-authors on ways to reduce misinformation.\n\n30 out of 34 pharmacists participated giving a response rate of 88.2%. Significant increases were seen (3-fold or more increase) in the consumption of hydroxychloroquine (100%), vitamins/immune boosters (96.7%) and antibiotics (46.7%) as well as PPE (100%). Considerable price increases (50% increase or greater) also seen for antimalarials (96.7%), antibiotics (93.3%), vitamins/immune boosters (66.7%), and PPE (100%). Shortages are also seen for hydroxychloroquine and vitamins/immune boosters but most severe for PPE (80% of pharmacies).\n\nEncouraging to see increases in the utilization of vitamins/immune boosters and PPE. However, a considerable increase in the utilization and prices of antimicrobials is a concern that needs addressing including misinformation. Community pharmacists have a key role in providing evidence-based advice and helping moderate prices.", "doi": "10.4103/jrpp.JRPP_20_92", "pmid": "34295848", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "JRPP-10-17"}, {"db": "pmc", "key": "PMC8259594"}], "notes": [], "created": "2021-08-05T11:08:14.212Z", "modified": "2021-08-05T11:08:14.238Z"}, {"entity": "publication", "iuid": "8aba6dd2ad9e4c22af045650c75a91d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8aba6dd2ad9e4c22af045650c75a91d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8aba6dd2ad9e4c22af045650c75a91d7"}}, "title": "A Framework-Based Approach to Assessing Mental Health Impacts of the COVID-19 Pandemic on Children and Adolescents.", "authors": [{"family": "Lin", "given": "Ping-I", "initials": "PI"}, {"family": "Srivastava", "given": "Gautam", "initials": "G"}, {"family": "Beckman", "given": "Linda", "initials": "L"}, {"family": "Kim", "given": "Yunhwan", "initials": "Y"}, {"family": "Hallerb\u00e4ck", "given": "Maria", "initials": "M"}, {"family": "Barzman", "given": "Drew", "initials": "D"}, {"family": "Sorter", "given": "Michael", "initials": "M"}, {"family": "Eapen", "given": "Valsamma", "initials": "V"}], "type": "journal article", "published": "2021-05-13", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "issue": null, "pages": "655481", "issn-l": "1664-0640"}, "abstract": "The COVID-19 pandemic has yielded extensive impacts globally in the year of 2020. Although the mental health of children and adolescents may be particularly susceptible to stressors stemming from the pandemic and anti-contagion policies, most ongoing efforts are geared toward curbing the viral spread. In the current perspective, we have identified four domains of factors corresponding to an ecological framework that may directly or indirectly influence the mental health of children and adolescents during the pandemic. The evidence suggests that anti-contagion policies might trigger cascades that impact the mental health of children and their families through multiple different sectors that used to form a safety net for youths. Additionally, children with neuropsychiatric disorders could experience exacerbated symptoms during the pandemic. Furthermore, the risk of domestic violence has surged during the pandemic, which further compounds the imminent mental health crisis. A mental health pandemic could be inevitable if no proactive prevention strategies were in place. Therefore, we recommend understanding each individual mental health risk pathway via the ecological framework in order to develop integrative prevention and intervention strategies.", "doi": "10.3389/fpsyt.2021.655481", "pmid": "34054613", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8155579"}], "notes": [], "created": "2021-06-04T11:29:09.017Z", "modified": "2021-06-04T11:29:24.098Z"}, {"entity": "publication", "iuid": "56d26eeb5c9c4efc996cfcb0c0f592be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56d26eeb5c9c4efc996cfcb0c0f592be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56d26eeb5c9c4efc996cfcb0c0f592be"}}, "title": "Prevention of COVID-19: Preventive Strategies for General Population, Healthcare Setting, and Various Professions.", "authors": [{"family": "Moossavi", "given": "Shirin", "initials": "S"}, {"family": "Fehr", "given": "Kelsey", "initials": "K"}, {"family": "Maleki", "given": "Hassan", "initials": "H"}, {"family": "Seyedpour", "given": "Simin", "initials": "S"}, {"family": "Keshavarz-Fathi", "given": "Mahdis", "initials": "M"}, {"family": "Tabasi", "given": "Farhad", "initials": "F"}, {"family": "Heravi", "given": "Mehrdad", "initials": "M"}, {"family": "Sharifian", "given": "Rayka", "initials": "R"}, {"family": "Shafiei", "given": "Golnaz", "initials": "G"}, {"family": "Badihian", "given": "Negin", "initials": "N"}, {"family": "Kelishadi", "given": "Roya", "initials": "R"}, {"family": "Nematollahi", "given": "Shahrzad", "initials": "S"}, {"family": "Almasi", "given": "Majid", "initials": "M"}, {"family": "Popescu", "given": "Saskia", "initials": "S"}, {"family": "Keshavarz-Fathi", "given": "Mahsa", "initials": "M"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}], "type": "journal article", "published": "2021-05-12", "journal": {"title": "Adv Exp Med Biol", "issn": "0065-2598", "volume": "1318", "issue": null, "pages": "575-604", "issn-l": null}, "abstract": "The disease 2019 (COVID-19) made a public health emergency in early 2020. Despite attempts for the development of therapeutic modalities, there is no effective treatment yet. Therefore, preventive measures in various settings could help reduce the burden of disease. In this chapter, the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19, non-pharmaceutical approaches at individual and population level, chemoprevention, immunoprevention, preventive measures in different healthcare settings and other professions, special considerations in high-risk groups, and the role of organizations to hamper the psychosocial effects will be discussed.", "doi": "10.1007/978-3-030-63761-3_32", "pmid": "33973200", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:54:33.345Z", "modified": "2021-05-17T18:54:33.367Z"}, {"entity": "publication", "iuid": "78f4a96977f74a7ab78fd1202cd37856", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/78f4a96977f74a7ab78fd1202cd37856.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/78f4a96977f74a7ab78fd1202cd37856"}}, "title": "Numbers don't speak for themselves: strategies of using numbers in public policy discourse.", "authors": [{"family": "Jablonka", "given": "Eva", "initials": "E", "orcid": "0000-0003-1019-792X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/99fa33b32e274c75b04539c706400382.json"}}, {"family": "Bergsten", "given": "Christer", "initials": "C", "orcid": "0000-0002-3681-3535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1f9cbb818e524b0f84a84f797d6e611a.json"}}], "type": "journal article", "published": "2021-05-12", "journal": {"title": "Educ Stud Math", "issn": "1573-0816", "pages": "1-18", "issn-l": null}, "abstract": "In mathematics education, there is general agreement regarding the significance of mathematical literacy (also quantitative literacy or numeracy) for informed citizenship, which often requires evaluating the use of numbers in public policy discourse. We hold that such an evaluation must accommodate the necessarily fragile relation between the information that numbers are taken to carry and the policy decisions they are meant to support. In doing so, attention needs to be paid to differences in how that relation is formed. With this in mind, we investigated a public discourse that heavily relied on numbers in the context of introducing, maintaining, and easing the rules and regulations directed to contain the spread of the virus SARS-CoV-2 during the first epidemic wave of COVID-19 in Germany with its peak in early April 2020. We used a public-service broadcasting outlet as data. Our theoretical stance is affiliated with post-structuralist discourse theory. As an outcome, we identified four major related strategies of using numbers, which we named rationalisation, contrast, association and recharging. In our view explicit attention to these strategies as well as identifying new ones can aid the task of furthering critical mathematical literacy.", "doi": "10.1007/s10649-021-10059-8", "pmid": "34934230", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10059"}, {"db": "pmc", "key": "PMC8113797"}], "notes": [], "created": "2022-01-03T15:31:26.383Z", "modified": "2022-01-03T15:31:26.492Z"}, {"entity": "publication", "iuid": "a8681cf4f3de46409df72b9d8c08063f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8681cf4f3de46409df72b9d8c08063f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8681cf4f3de46409df72b9d8c08063f"}}, "title": "Coronavirus: Pure Infectious Disease or Genetic Predisposition.", "authors": [{"family": "Darbeheshti", "given": "Farzaneh", "initials": "F"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Bashashati", "given": "Mohammad", "initials": "M"}, {"family": "Ghavami", "given": "Saeid", "initials": "S"}, {"family": "Shahkarami", "given": "Sepideh", "initials": "S"}, {"family": "Zoghi", "given": "Samaneh", "initials": "S"}, {"family": "Gupta", "given": "Sudhir", "initials": "S"}, {"family": "Orange", "given": "Jordan S", "initials": "JS"}, {"family": "Ochs", "given": "Hans D", "initials": "HD"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}], "type": "journal article", "published": "2021-05-12", "journal": {"title": "Adv Exp Med Biol", "issn": "0065-2598", "volume": "1318", "issue": null, "pages": "91-107", "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes novel coronavirus disease (COVID-19), is the seventh pathogenic coronavirus recently discovered in December 2019 in Wuhan, China. To date, our knowledge about its effect on the human host remains limited. It is well known that host genetic factors account for the individual differences in the susceptibility to infectious diseases. The genetic susceptibility factors to COVID-19 and its severity are associated with several unanswered questions. However, the experience gained from an earlier strain of coronavirus, SARS-CoV-1, which shows 78% genetic similarity to SARS-CoV-2 and uses the same receptor to bind to host cells, could provide some clues. It, therefore, seems possible to assemble new evidence in order to solve a potential genetic predisposition puzzle for COVID-19. In this chapter, the puzzle pieces, including virus entry receptors, immune response, and inflammation-related genes, as well as the probable genetic predisposition models to COVID-19, are discussed.", "doi": "10.1007/978-3-030-63761-3_6", "pmid": "33973174", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:55:51.197Z", "modified": "2021-05-17T18:55:51.207Z"}, {"entity": "publication", "iuid": "5650033701204a63a0f7f17812cdf653", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5650033701204a63a0f7f17812cdf653.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5650033701204a63a0f7f17812cdf653"}}, "title": "Combined Cardiac Risk Factors Predict COVID-19 Related Mortality and the Need for Mechanical Ventilation in Coptic Clergy.", "authors": [{"family": "Henein", "given": "Michael Y", "initials": "MY"}, {"family": "Byty\u00e7i", "given": "Ibadete", "initials": "I"}, {"family": "Nicoll", "given": "Rachel", "initials": "R"}, {"family": "Shenouda", "given": "Rafik", "initials": "R"}, {"family": "Ayad", "given": "Sherif", "initials": "S"}, {"family": "Cameli", "given": "Matteo", "initials": "M"}, {"family": "Vancheri", "given": "Federico", "initials": "F"}], "type": "journal article", "published": "2021-05-12", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "10", "issue": "10", "issn-l": "2077-0383"}, "abstract": "The clinical adverse events of COVID-19 among clergy worldwide have been found to be higher than among ordinary communities, probably because of the nature of their work. The aim of this study was to assess the impact of cardiac risk factors on COVID-19-related mortality and the need for mechanical ventilation in Coptic clergy.\n\nOf 1570 Coptic clergy participating in the COVID-19-Clergy study, serving in Egypt, USA and Europe, 213 had the infection and were included in this analysis. Based on the presence of systemic arterial hypertension (AH), participants were divided into two groups: Group-I, clergy with AH ( n = 77) and Group-II, without AH (n = 136). Participants' demographic indices, cardiovascular risk factors, COVID-19 management details and related mortality were assessed.\n\nClergy with AH were older ( p < 0.001), more obese (p = 0.04), had frequent type 2 diabetes (DM) (p = 0.001), dyslipidemia (p = 0.001) and coronary heart disease (CHD) (p = 0.04) compared to those without AH. COVID-19 treatment at home, hospital or in intensive care did not differ between the patient groups (p > 0.05 for all). Clergy serving in Northern and Southern Egypt had a higher mortality rate compared to those from Europe and the USA combined (5.22%, 6.38%, 0%; p = 0.001). The impact of AH on mortality was significant only in Southern Egypt (10% vs. 3.7%; p = 0.01) but not in Northern Egypt (4.88% vs. 5.81%; p = 0.43). In multivariate analysis, CHD OR 1.607 ((0.982 to 3.051); p = 0.02) and obesity, OR 3.403 ((1.902 to 4.694); p = 0.04) predicted COVID-19 related mortality. A model combining cardiac risk factors (systolic blood pressure (SBP) \u2265 160 mmHg, DM, obesity and history of CHD) was the most powerful independent predictor of COVID-19-related mortality, OR 3.991 ((1.919 to 6.844); p = 0.002). Almost the same model also proved the best independent multivariate predictor of mechanical ventilation OR 1.501 ((0.809 to 6.108); p = 0.001).\n\nIn Coptic clergy, the cumulative impact of risk factors was the most powerful predictor of mortality and the need for mechanical ventilation.", "doi": "10.3390/jcm10102066", "pmid": "34065902", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jcm10102066"}], "notes": [], "created": "2021-06-04T11:23:13.799Z", "modified": "2021-06-04T11:23:36.205Z"}, {"entity": "publication", "iuid": "b9123a86798d42579531d0a65f4020b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9123a86798d42579531d0a65f4020b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9123a86798d42579531d0a65f4020b2"}}, "title": "COVID-19 in Patients with Cancer.", "authors": [{"family": "Nowroozi", "given": "Ali", "initials": "A"}, {"family": "Razi", "given": "Sepideh", "initials": "S"}, {"family": "Sahu", "given": "Kamal Kant", "initials": "KK"}, {"family": "Grizzi", "given": "Fabio", "initials": "F"}, {"family": "Arends", "given": "Jann", "initials": "J"}, {"family": "Keshavarz-Fathi", "given": "Mahsa", "initials": "M"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}], "type": "journal article", "published": "2021-05-12", "journal": {"title": "Adv Exp Med Biol", "issn": "0065-2598", "volume": "1318", "issue": null, "pages": "315-331", "issn-l": null}, "abstract": "With more than 5 million cases and 333,212 deaths, COVID-19 (or SARS-CoV-2) continues to spread. General symptoms of this disease are similar to that of many other viral respiratory diseases, including fever, cough, dyspnea, and fatigue, with a chance of progression to more severe complications. However, the virus does not affect all people equally, and cases with comorbidities such as malignancies, cardiovascular diseases, respiratory diseases, and kidney diseases are at higher risk of developing severe events, including requiring intensive ventilation, intensive care unit (ICU) admission, and death. Patients with cancer are more likely to be infected with COVID-19, which is possibly due to their immunological dysfunction or frequent clinic visits. Also, there is a higher chance that these patients experience severe events because of the medication they receive. In this chapter, we will review the main clinical manifestations of COVID-19 in patients with cancer. Recommendations and challenges for managing resources, organizing cancer centers, treatment of COVID-19-infected cancer patients, and performing cancer research during this pandemic will also be discussed.", "doi": "10.1007/978-3-030-63761-3_18", "pmid": "33973186", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:55:05.544Z", "modified": "2021-05-17T18:55:05.556Z"}, {"entity": "publication", "iuid": "a4272f9b05514336a607b145e6c4528a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a4272f9b05514336a607b145e6c4528a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a4272f9b05514336a607b145e6c4528a"}}, "title": "Beyond brick and mortar: staying connected in post-pandemic blended learning environments.", "authors": [{"family": "McGrath", "given": "Cormac", "initials": "C"}, {"family": "Palmgren", "given": "Per J", "initials": "PJ"}, {"family": "Liljedahl", "given": "Matilda", "initials": "M"}], "type": "journal article", "published": "2021-05-12", "journal": {"title": "Med Educ", "issn": "1365-2923", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "These are certainly unprecedented times and the ongoing Covid-19 pandemic has turned many ideas about teaching and learning in medical education on their head. Who would have thought that, overnight, brick and mortar universities would be providing education solely through digital means? This form of radical change comes along perhaps once in a lifetime, and currently we have not seen the full fallout, or the potential benefits from the sudden and dramatic shift in medical education. More than a year later, we still find ourselves telecommuting in front of our screens; teaching, supervising, and assessing.", "doi": "10.1111/medu.14546", "pmid": "33977575", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:47:19.209Z", "modified": "2022-11-22T05:47:36.508Z"}, {"entity": "publication", "iuid": "6bed9e4cb4c945d8b93a6c6339fd8fa8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6bed9e4cb4c945d8b93a6c6339fd8fa8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6bed9e4cb4c945d8b93a6c6339fd8fa8"}}, "title": "Use of repurposed and adjuvant drugs in hospital patients with covid-19: multinational network cohort study.", "authors": [{"family": "Prats-Uribe", "given": "Albert", "initials": "A"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Lai", "given": "Lana Yin Hui", "initials": "LYH"}, {"family": "Ahmed", "given": "Waheed-Ul-Rahman", "initials": "WU"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Carter", "given": "William", "initials": "W"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "Dawoud", "given": "Dalia", "initials": "D"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Jonnagaddala", "given": "Jitendra", "initials": "J"}, {"family": "Mehta", "given": "Paras P", "initials": "PP"}, {"family": "Gong", "given": "Mengchun", "initials": "M"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Recalde", "given": "Martina", "initials": "M"}, {"family": "Roel", "given": "Elena", "initials": "E"}, {"family": "Shah", "given": "Karishma", "initials": "K"}, {"family": "Shah", "given": "Nigam H", "initials": "NH"}, {"family": "Schilling", "given": "Lisa M", "initials": "LM"}, {"family": "Subbian", "given": "Vignesh", "initials": "V"}, {"family": "Vizcaya", "given": "David", "initials": "D"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhang", "given": "Ying", "initials": "Y"}, {"family": "Zhu", "given": "Hong", "initials": "H"}, {"family": "Liu", "given": "Li", "initials": "L"}, {"family": "Cho", "given": "Jaehyeong", "initials": "J"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Lane", "given": "Jennifer Ce", "initials": "JC"}, {"family": "Burn", "given": "Edward", "initials": "E"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Ryan", "given": "Patrick B", "initials": "PB", "orcid": "0000-0002-9727-2138", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7f5f6d8b6bb4d85b1430cda6aea55b8.json"}}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "373", "issue": null, "pages": "n1038", "issn-l": null}, "abstract": "To investigate the use of repurposed and adjuvant drugs in patients admitted to hospital with covid-19 across three continents.\n\nMultinational network cohort study.\n\nHospital electronic health records from the United States, Spain, and China, and nationwide claims data from South Korea.\n\n303 264 patients admitted to hospital with covid-19 from January 2020 to December 2020.\n\nPrescriptions or dispensations of any drug on or 30 days after the date of hospital admission for covid-19.\n\nOf the 303 264 patients included, 290 131 were from the US, 7599 from South Korea, 5230 from Spain, and 304 from China. 3455 drugs were identified. Common repurposed drugs were hydroxychloroquine (used in from <5 (<2%) patients in China to 2165 (85.1%) in Spain), azithromycin (from 15 (4.9%) in China to 1473 (57.9%) in Spain), combined lopinavir and ritonavir (from 156 (<2%) in the VA-OMOP US to 2,652 (34.9%) in South Korea and 1285 (50.5%) in Spain), and umifenovir (0% in the US, South Korea, and Spain and 238 (78.3%) in China). Use of adjunctive drugs varied greatly, with the five most used treatments being enoxaparin, fluoroquinolones, ceftriaxone, vitamin D, and corticosteroids. Hydroxychloroquine use increased rapidly from March to April 2020 but declined steeply in May to June and remained low for the rest of the year. The use of dexamethasone and corticosteroids increased steadily during 2020.\n\nMultiple drugs were used in the first few months of the covid-19 pandemic, with substantial geographical and temporal variation. Hydroxychloroquine, azithromycin, lopinavir-ritonavir, and umifenovir (in China only) were the most prescribed repurposed drugs. Antithrombotics, antibiotics, H2 receptor antagonists, and corticosteroids were often used as adjunctive treatments. Research is needed on the comparative risk and benefit of these treatments in the management of covid-19.", "doi": "10.1136/bmj.n1038", "pmid": "33975825", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC8111167"}], "notes": [], "created": "2021-05-17T18:47:58.975Z", "modified": "2023-06-19T15:36:24.527Z"}, {"entity": "publication", "iuid": "29339962371649a685dbe773e103b82d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/29339962371649a685dbe773e103b82d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/29339962371649a685dbe773e103b82d"}}, "title": "Transformation of primary care during the COVID-19 pandemic: experiences of healthcare professionals in eight European countries.", "authors": [{"family": "Wanat", "given": "Marta", "initials": "M"}, {"family": "Hoste", "given": "Melanie", "initials": "M"}, {"family": "Gobat", "given": "Nina", "initials": "N"}, {"family": "Anastasaki", "given": "Marilena", "initials": "M"}, {"family": "Boehmer", "given": "Femke", "initials": "F"}, {"family": "Chlabicz", "given": "Slawomir", "initials": "S"}, {"family": "Colliers", "given": "Annelies", "initials": "A"}, {"family": "Farrell", "given": "Karen", "initials": "K"}, {"family": "Karkana", "given": "Maria-Nefeli", "initials": "MN"}, {"family": "Kinsman", "given": "John", "initials": "J"}, {"family": "Lionis", "given": "Christos", "initials": "C"}, {"family": "Marcinowicz", "given": "Ludmila", "initials": "L"}, {"family": "Reinhardt", "given": "Katrin", "initials": "K"}, {"family": "Skoglund", "given": "Ingmarie", "initials": "I"}, {"family": "Sundvall", "given": "P\u00e4r-Daniel", "initials": "PD"}, {"family": "Vellinga", "given": "Akke", "initials": "A"}, {"family": "Verheij", "given": "Theo", "initials": "T"}, {"family": "Goossens", "given": "Herman", "initials": "H"}, {"family": "Butler", "given": "Christopher", "initials": "C"}, {"family": "van der Velden", "given": "Alike", "initials": "A"}, {"family": "Anthierens", "given": "Sibyl", "initials": "S"}, {"family": "Tonkin-Crine", "given": "Sarah", "initials": "S"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Br J Gen Pract", "issn": "1478-5242", "volume": null, "issue": null, "issn-l": null}, "abstract": "Primary care has a crucial role in responding to the COVID-19 pandemic as the first point of patient care and gatekeeper to secondary care. Qualitative studies exploring the experiences of healthcare professionals during the COVID-19 pandemic have mainly focused on secondary care.\n\nTo understand the experiences of European PCPs working during the first peak of the COVID-19 pandemic.\n\nAn exploratory qualitative study, using semi-structured interviews in primary care in England, Belgium, the Netherlands, Ireland, Germany, Poland, Greece and Sweden, between April and July 2020.\n\nInterviews were audio recorded, transcribed and analysed using a combination of inductive and deductive thematic analysis techniques.\n\nEighty interviews were conducted with PCPs. PCPs had to make their own decisions on how to rapidly transform services in relation to COVID-19 and non-COVID-19 care. Despite being overwhelmed with guidance, they often lacked access to practical training. Consequently, PCPs turned to their colleagues for moral support and information to try to quickly adjust to new ways of working, including remote care, and deal with uncertainty.\n\nPCPs rapidly transformed primary care delivery despite a number of challenges. Representation of primary care at policy level and engagement with local primary care champions will facilitate easy and coordinated access to practical information on how to adapt services, ongoing training and access to appropriate mental health support services for PCPs. Preservation of autonomy and responsiveness of primary care are critical to preserve the ability for rapid transformation in any future crisis of care delivery.", "doi": "10.3399/BJGP.2020.1112", "pmid": "33979303", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "BJGP.2020.1112"}], "notes": [], "created": "2021-05-17T18:43:33.883Z", "modified": "2021-05-21T17:01:41.572Z"}, {"entity": "publication", "iuid": "e215aad9f53e4b84850559d85c40ea41", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e215aad9f53e4b84850559d85c40ea41.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e215aad9f53e4b84850559d85c40ea41"}}, "title": "The perfect storm: Disruptions to institutional delivery care arising from the COVID-19 pandemic in Nepal.", "authors": [{"family": "Ashish", "given": "K C", "initials": "KC"}, {"family": "Peterson", "given": "Stefan Swartling", "initials": "SS"}, {"family": "Gurung", "given": "Rejina", "initials": "R"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A"}, {"family": "Gautam", "given": "Jageshwar", "initials": "J"}, {"family": "Malla", "given": "Honey", "initials": "H"}, {"family": "Paudel", "given": "Punya", "initials": "P"}, {"family": "Bhattarai", "given": "Kumari", "initials": "K"}, {"family": "Joshi", "given": "Nisha", "initials": "N"}, {"family": "Tinkari", "given": "Bhim Singh", "initials": "BS"}, {"family": "Adhikari", "given": "Shree", "initials": "S"}, {"family": "Shrestha", "given": "Durgalaxmi", "initials": "D"}, {"family": "Ghimire", "given": "Binda", "initials": "B"}, {"family": "Sharma", "given": "Seema", "initials": "S"}, {"family": "Khanal", "given": "Laxmi", "initials": "L"}, {"family": "Shrestha", "given": "Sunil", "initials": "S"}, {"family": "Graham", "given": "Wendy Jane", "initials": "WJ"}, {"family": "Kinney", "given": "Mary", "initials": "M"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "J Glob Health", "issn": "2047-2986", "volume": "11", "issue": null, "pages": "05010", "issn-l": "2047-2978"}, "abstract": "The COVID-19 pandemic has led to system-wide disruption of health services globally. We assessed the effect of the pandemic on the disruption of institutional delivery care in Nepal.\n\nWe conducted a prospective cohort study among 52 356 women in nine hospitals to assess the disruption of institutional delivery care during the pandemic (comparing March to August in 2019 with the same months in 2020). We also conducted a nested follow up cohort study with 2022 women during the pandemic to assess their provision and experience of respectful care. We used linear regression models to assess the association between provision and experience of care with volume of hospital births and women's residence in a COVID-19 hotspot area.\n\nThe mean institutional births during the pandemic across the nine hospitals was 24 563, an average decrease of 11.6% ( P < 0.0001) in comparison to the same time-period in 2019. The institutional birth in high-medium volume hospitals declined on average by 20.8% (P < 0.0001) during the pandemic, whereas in low-volume hospital institutional birth increased on average by 7.9% (P = 0.001). Maternity services halted for a mean of 4.3 days during the pandemic and there was a redeployment staff to COVID-19 dedicated care. Respectful provision of care was better in hospitals with low-volume birth (\u03b2 = 0.446, P < 0.0001) in comparison to high-medium-volume hospitals. There was a positive association between women's residence in a COVID-19 hotspot area and respectful experience of care (\u03b2 = 0.076, P = 0.001).\n\nThe COVID-19 pandemic has had differential effects on maternity services with changes varying by the volume of births per hospital with smaller volume facilities doing better. More research is needed to investigate the effects of the pandemic on where women give birth and their provision and experience of respectful maternity care to inform a \"building-back-better\" approach in post-pandemic period.", "doi": "10.7189/jogh.11.05010", "pmid": "34055329", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "jogh-11-05010"}, {"db": "pmc", "key": "PMC8141327"}], "notes": [], "created": "2021-06-04T11:28:42.299Z", "modified": "2021-06-04T11:28:42.309Z"}, {"entity": "publication", "iuid": "40cf5150085a4046a75dc1f9fe386a62", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/40cf5150085a4046a75dc1f9fe386a62.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/40cf5150085a4046a75dc1f9fe386a62"}}, "title": "Social distancing during the COVID-19 pandemic and health-related quality of life among esophageal cancer survivors.", "authors": [{"family": "Schandl", "given": "Anna", "initials": "A"}, {"family": "M\u00e4lberg", "given": "Kalle", "initials": "K"}, {"family": "Johar", "given": "Asif", "initials": "A"}, {"family": "Lagergren", "given": "Pernilla", "initials": "P"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Acta Oncol", "issn": "1651-226X", "volume": null, "issue": null, "pages": "1-8", "issn-l": null}, "abstract": "The purpose was to investigate whether social distancing during the COVID-19 pandemic reduced health-related quality of life (HRQL) in esophageal cancer patients and if so, to identify factors related to the HRQL changes.\n\nA prospective Swedish nationwide study of patients who undergone surgery for esophageal cancer between 2013 and 2019. Telephone interviews were conducted 5 weeks and 13 weeks after the introduction of social distancing recommendations. The participants responded to a few scales and items from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30. Regression models adjusted for potential confounders were used to examine mean score differences (MSD) with 95% confidence intervals (CI) between compliance with the recommendations and HRQL.\n\nIn total, 134 individuals participated in the study. At 5 weeks, a reduction in role function was seen for individuals who fully (MSD -8, 95% CI: -16 to 0) and to a large extent (MSD -19, 95% CI: -26 to -12) complied with the recommendations. Less fatigue (MSD 9, 95% CI: 3-15) was also detected for this group. Being female, elderly, having comorbidities, living in a region with higher COVID-19 incidence, living in a villa, and being considered as an at-risk person were related to changes in role function. At 13 weeks, reductions in role function continued for those who fully complied with the recommendations (MSD -10, 95% CI: -19 to -1), but the risk variables were of less importance. Improvements in fatigue were no longer detected. Global quality of life, emotional function, or insomnia remained stable over time.\n\nThis study indicates that individuals who undergone surgery for esophageal cancer and fully or to a large extent complied with the recommendations experienced reductions in role function, but not in global quality of life or emotional function, during the COVID-19 pandemic.", "doi": "10.1080/0284186X.2021.1921260", "pmid": "33974501", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:50:05.413Z", "modified": "2021-05-17T18:50:05.423Z"}, {"entity": "publication", "iuid": "762b430a5e3b4c3d809a370ec4193981", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/762b430a5e3b4c3d809a370ec4193981.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/762b430a5e3b4c3d809a370ec4193981"}}, "title": "Post-outbreak serological screening for SARS-CoV-2 infection in healthcare workers at a Swedish University Hospital.", "authors": [{"family": "Strand", "given": "Rasmus", "initials": "R"}, {"family": "Fernstr\u00f6m", "given": "Nils", "initials": "N"}, {"family": "Holmberg", "given": "Anna", "initials": "A"}, {"family": "De Marinis", "given": "Yang", "initials": "Y"}, {"family": "Fraenkel", "given": "Carl-Johan", "initials": "C"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": null, "issue": null, "pages": "1-6"}, "abstract": "Nosocomial outbreaks of coronavirus disease 2019 (COVID-19) can have devastating consequences from both a resource cost and patient healthcare perspective. Relying on reverse transcription-polymerase chain reaction (RT-PCR) for identifying infected individuals may result in missed cases. Screening for antibodies after an outbreak can help to find missed cases and better illuminate routes of transmission.\r\n\r\nIn this study, we present the results of a serological screening of the healthcare workers (HCWs) on a ward for infectious diseases in Sweden with a point-of-care antibody test 8 weeks after an outbreak of COVID-19. In all, 107/123 (87%) of HCWs who were tested with RT-PCR in the outbreak investigation participated in this study on seroprevalence. Participants were also asked to fill out a questionnaire entailing epidemiological data. The cohort was stratified by RT-PCR result and the resulting groups were compared to each other.\r\n\r\nSix (8%) HCWs who were tested RT-PCR negative during the outbreak investigation had developed specific IgG antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These HCWs had all worked shifts with colleagues who later were tested RT-PCR positive during the outbreak.\r\n\r\nOur results indicate that a serological follow-up screening after an outbreak may be used as a complement to virus detection in an outbreak situation. However, immunoglobulin (Ig) G-detection should also be performed at the start of an outbreak, to facilitate interpretation of the results.", "doi": "10.1080/23744235.2021.1925739", "pmid": "33974498", "labels": {"Type: Journal article": null, "Category: Serology": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:51:24.712Z", "modified": "2021-06-18T08:53:08.301Z"}, {"entity": "publication", "iuid": "930d2a63267f4a5babddd655671ec80b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/930d2a63267f4a5babddd655671ec80b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/930d2a63267f4a5babddd655671ec80b"}}, "title": "Nutritional management of individuals with obesity and COVID-19: ESPEN expert statements and practical guidance.", "authors": [{"family": "Barazzoni", "given": "Rocco", "initials": "R"}, {"family": "Bischoff", "given": "Stephan C", "initials": "SC"}, {"family": "Busetto", "given": "Luca", "initials": "L"}, {"family": "Cederholm", "given": "Tommy", "initials": "T"}, {"family": "Chourdakis", "given": "Michael", "initials": "M"}, {"family": "Cuerda", "given": "Cristina", "initials": "C"}, {"family": "Delzenne", "given": "Nathalie", "initials": "N"}, {"family": "Genton", "given": "Laurence", "initials": "L"}, {"family": "Schneider", "given": "Stephane", "initials": "S"}, {"family": "Singer", "given": "Pierre", "initials": "P"}, {"family": "Boirie", "given": "Yves", "initials": "Y"}, {"family": "endorsed by the ESPEN Council", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Clin Nutr", "issn": "1532-1983", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemics has created unprecedented challenges and threats to patients and healthcare systems worldwide. Acute respiratory complications that require intensive care unit (ICU) management are a major cause of morbidity and mortality in COVID-19 patients. Among other important risk factors for severe COVID-19 outcomes, obesity has emerged along with undernutrition-malnutrition as a strong predictor of disease risk and severity. Obesity-related excessive body fat may lead to respiratory, metabolic and immune derangements potentially favoring the onset of COVID-19 complications. In addition, patients with obesity may be at risk for loss of skeletal muscle mass, reflecting a state of hidden malnutrition with a strong negative health impact in all clinical settings. Also importantly, obesity is commonly associated with micronutrient deficiencies that directly influence immune function and infection risk. Finally, the pandemic-related lockdown, deleterious lifestyle changes and other numerous psychosocial consequences may worsen eating behaviors, sedentarity, body weight regulation, ultimately leading to further increments of obesity-associated metabolic complications with loss of skeletal muscle mass and higher non-communicable disease risk. Therefore, prevention, diagnosis and treatment of malnutrition and micronutrient deficiencies should be routinely included in the management of COVID-19 patients in the presence of obesity; lockdown-induced health risks should also be specifically monitored and prevented in this population. In the current document, the European Society for Clinical Nutrition and Metabolism (ESPEN) aims at providing clinical practice guidance for nutritional management of COVID-19 patients with obesity in various clinical settings.", "doi": "10.1016/j.clnu.2021.05.006", "pmid": "34140163", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0261-5614(21)00248-X"}, {"db": "pmc", "key": "PMC8110326"}], "notes": [], "created": "2021-06-28T18:30:11.127Z", "modified": "2021-06-28T18:30:42.013Z"}, {"entity": "publication", "iuid": "3a2fb90fbc5c49049f3760352f9c6421", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a2fb90fbc5c49049f3760352f9c6421.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a2fb90fbc5c49049f3760352f9c6421"}}, "title": "Institutional and behaviour-change interventions to support COVID-19 public health measures: a review by the Lancet Commission Task Force on public health measures to suppress the pandemic.", "authors": [{"family": "Lee", "given": "Jong-Koo", "initials": "JK"}, {"family": "Bullen", "given": "Chris", "initials": "C"}, {"family": "Ben Amor", "given": "Yanis", "initials": "Y"}, {"family": "Bush", "given": "Simon R", "initials": "SR"}, {"family": "Colombo", "given": "Francesca", "initials": "F"}, {"family": "Gaviria", "given": "Alejandro", "initials": "A"}, {"family": "Karim", "given": "Salim S Abdool", "initials": "SSA"}, {"family": "Kim", "given": "Booyuel", "initials": "B"}, {"family": "Lavis", "given": "John N", "initials": "JN"}, {"family": "Lazarus", "given": "Jeffrey V", "initials": "JV"}, {"family": "Lo", "given": "Yi-Chun", "initials": "YC"}, {"family": "Michie", "given": "Susan F", "initials": "SF"}, {"family": "Norheim", "given": "Ole F", "initials": "OF"}, {"family": "Oh", "given": "Juhwan", "initials": "J"}, {"family": "Reddy", "given": "Kolli Srinath", "initials": "KS"}, {"family": "Rostila", "given": "Mikael", "initials": "M"}, {"family": "S\u00e1enz", "given": "Roc\u00edo", "initials": "R"}, {"family": "Smith", "given": "Liam D G", "initials": "LDG"}, {"family": "Thwaites", "given": "John W", "initials": "JW"}, {"family": "Were", "given": "Miriam K", "initials": "MK"}, {"family": "Xue", "given": "Lan", "initials": "L"}, {"family": "(The Lancet COVID-19 Commission Task Force for Public Health Measures to Suppress the Pandemic)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Int Health", "issn": "1876-3405", "volume": null, "issue": null, "issn-l": null}, "abstract": "The Lancet COVID-19 Commission Task Force for Public Health Measures to Suppress the Pandemic was launched to identify critical points for consideration by governments on public health interventions to control coronavirus disease 2019 (COVID-19). Drawing on our review of published studies of data analytics and modelling, evidence synthesis and contextualisation, and behavioural science evidence and theory on public health interventions from a range of sources, we outline evidence for a range of institutional measures and behaviour-change measures. We cite examples of measures adopted by a range of countries, but especially jurisdictions that have, thus far, achieved low numbers of COVID-19 deaths and limited community transmission of severe acute respiratory syndrome coronavirus 2. Finally, we highlight gaps in knowledge where research should be undertaken. As countries consider long-term measures, there is an opportunity to learn, improve the response and prepare for future pandemics.", "doi": "10.1093/inthealth/ihab022", "pmid": "33974687", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "6273788"}], "notes": [], "created": "2021-05-17T18:49:29.351Z", "modified": "2021-05-17T18:49:41.581Z"}, {"entity": "publication", "iuid": "fa6a7a05e2074cd1a7402b7d09a56c8e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa6a7a05e2074cd1a7402b7d09a56c8e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa6a7a05e2074cd1a7402b7d09a56c8e"}}, "title": "High but slightly declining COVID-19 vaccine acceptance and reasons for vaccine acceptance, Finland April to December 2020.", "authors": [{"family": "Hammer", "given": "Charlotte C", "initials": "CC"}, {"family": "Cristea", "given": "Veronica", "initials": "V"}, {"family": "Dub", "given": "Timothee", "initials": "T"}, {"family": "Sivel\u00e4", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "issn-l": null, "volume": null, "issue": null, "pages": "1-19"}, "abstract": null, "doi": "10.1017/S0950268821001114", "pmid": "33972001", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0950268821001114"}], "notes": [], "created": "2021-05-17T18:56:22.538Z", "modified": "2021-07-14T08:51:02.585Z"}, {"entity": "publication", "iuid": "eadf0103347c4a33b1fe4952b6eec997", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eadf0103347c4a33b1fe4952b6eec997.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eadf0103347c4a33b1fe4952b6eec997"}}, "title": "Evidence-Based Health Informatics as the Foundation for the COVID-19 Response: A Joint Call for Action.", "authors": [{"family": "Fernandez-Luque", "given": "Luis", "initials": "L"}, {"family": "Kushniruk", "given": "Andre W", "initials": "AW"}, {"family": "Georgiou", "given": "Andrew", "initials": "A"}, {"family": "Basu", "given": "Arindam", "initials": "A"}, {"family": "Petersen", "given": "Carolyn", "initials": "C"}, {"family": "Ronquillo", "given": "Charlene", "initials": "C"}, {"family": "Paton", "given": "Chris", "initials": "C"}, {"family": "N\u00f8hr", "given": "Christian", "initials": "C"}, {"family": "Kuziemsky", "given": "Craig E", "initials": "CE"}, {"family": "Alhuwail", "given": "Dari", "initials": "D"}, {"family": "Skiba", "given": "Diane", "initials": "D"}, {"family": "Huesing", "given": "Elaine", "initials": "E"}, {"family": "Gabarron", "given": "Elia", "initials": "E"}, {"family": "Borycki", "given": "Elizabeth M", "initials": "EM"}, {"family": "Magrabi", "given": "Farah", "initials": "F"}, {"family": "Denecke", "given": "Kerstin", "initials": "K"}, {"family": "Peute", "given": "Linda W P", "initials": "LWP"}, {"family": "Topaz", "given": "Max", "initials": "M"}, {"family": "Al-Shorbaji", "given": "Najeeb", "initials": "N"}, {"family": "Lacroix", "given": "Paulette", "initials": "P"}, {"family": "Marcilly", "given": "Romaric", "initials": "R"}, {"family": "Cornet", "given": "Ronald", "initials": "R"}, {"family": "Gogia", "given": "Shashi B", "initials": "SB"}, {"family": "Kobayashi", "given": "Shinji", "initials": "S"}, {"family": "Iyengar", "given": "Sriram", "initials": "S"}, {"family": "Deserno", "given": "Thomas M", "initials": "TM"}, {"family": "Mettler", "given": "Tobias", "initials": "T"}, {"family": "Vimarlund", "given": "Vivian", "initials": "V"}, {"family": "Zhu", "given": "Xinxin", "initials": "X"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Methods Inf Med", "issn": "2511-705X", "volume": null, "issue": null, "issn-l": null}, "abstract": "As a major public health crisis, the novel coronavirus disease 2019 (COVID-19) pandemic demonstrates the urgent need for safe, effective, and evidence-based implementations of digital health. The urgency stems from the frequent tendency to focus attention on seemingly high promising digital health interventions despite being poorly validated in times of crisis.\n\nIn this paper, we describe a joint call for action to use and leverage evidence-based health informatics as the foundation for the COVID-19 response and public health interventions. Tangible examples are provided for how the working groups and special interest groups of the International Medical Informatics Association (IMIA) are helping to build an evidence-based response to this crisis.\n\nLeaders of working and special interest groups of the IMIA, a total of 26 groups, were contacted via e-mail to provide a summary of the scientific-based efforts taken to combat COVID-19 pandemic and participate in the discussion toward the creation of this manuscript. A total of 13 groups participated in this manuscript.\n\nVarious efforts were exerted by members of IMIA including (1) developing evidence-based guidelines for the design and deployment of digital health solutions during COVID-19; (2) surveying clinical informaticians internationally about key digital solutions deployed to combat COVID-19 and the challenges faced when implementing and using them; and (3) offering necessary resources for clinicians about the use of digital tools in clinical practice, education, and research during COVID-19.\n\nRigor and evidence need to be taken into consideration when designing, implementing, and using digital tools to combat COVID-19 to avoid delays and unforeseen negative consequences. It is paramount to employ a multidisciplinary approach for the development and implementation of digital health tools that have been rapidly deployed in response to the pandemic bearing in mind human factors, ethics, data privacy, and the diversity of context at the local, national, and international levels. The training and capacity building of front-line workers is crucial and must be linked to a clear strategy for evaluation of ongoing experiences.", "doi": "10.1055/s-0041-1726414", "pmid": "33975375", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:48:34.073Z", "modified": "2021-05-17T18:48:43.627Z"}, {"entity": "publication", "iuid": "aa21976a6f8245e8b4dd38c8e7bc90af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aa21976a6f8245e8b4dd38c8e7bc90af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aa21976a6f8245e8b4dd38c8e7bc90af"}}, "title": "COVID-19, Livestock Systems and Food Security in Developing Countries: A Systematic Review of an Emerging Literature.", "authors": [{"family": "Abu Hatab", "given": "Assem", "initials": "A"}, {"family": "Krautscheid", "given": "Lena", "initials": "L"}, {"family": "Boqvist", "given": "Sofia", "initials": "S"}], "type": "journal article", "published": "2021-05-11", "journal": {"title": "Pathogens", "issn": "2076-0817", "volume": "10", "issue": "5", "issn-l": "2076-0817"}, "abstract": "In this paper, we carried out a systematic literature review to document the emerging scientific knowledge about COVID-19 impact on livestock systems and food security in developing countries to identify gaps and possible avenues for future research undertakings. Specifically, we systematically reviewed 68 peer-reviewed articles extracted based on rigorous selection criteria from Scopus, PubMed and ISI Web of Science databases and published between December 2019 and February 2021. Our results reveal that livestock supply chains presented an important 'intermediary' pathway through which the pandemic affected various dimensions of food security in developing countries. Although the research response has been rapid in terms of both quantity and temporal succession, we find a highly suggestive disjunction in studies analyzing the interconnections between COVID-19 pandemic, livestock systems and food security in developing countries. With respect to the livestock supply chain, the bulk of the reviewed evidence focuses on production and consumption, whereas considerably less focus is given to the pandemic's impact on intermediaries within livestock chains, including traders, intermediaries and processors. The analysis of livestock supply chain resilience revolves predominantly around the 'absorbance' and 'recovery' phases of resilience, whereas only a small subset of the literature investigates actions taken by supply chain actors to 'plan' or to 'adapt' livestock systems in order to reduce their vulnerability and enhance their overall resilience. Furthermore, food security has often been narrowly defined, with the majority of articles focusing on 'availability' and 'accessibility' to food due to the pandemic, and other dimensions of food security, including utilization, stability and sustainability, have been widely neglected. Based on our findings, we recommend future research to examine the dynamics of propagation of COVID-19 impact through livestock supply chains in order to develop more targeted interventions that enhance the capacity of developing countries to cope with this and future disruptions and mitigate their food insecurity outcomes. To this end, more holistic, integrated and resilience-based approaches are much recommended to recognize the complex nature of livestock systems in developing countries and to address the multifaceted and widespread effects of COVID-19 on food security channeled through livestock chains.", "doi": "10.3390/pathogens10050586", "pmid": "34064749", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "pathogens10050586"}], "notes": [], "created": "2021-06-04T11:23:46.972Z", "modified": "2021-06-04T11:23:46.975Z"}, {"entity": "publication", "iuid": "79c11d5578e0406d9e0a6d1106918137", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79c11d5578e0406d9e0a6d1106918137.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79c11d5578e0406d9e0a6d1106918137"}}, "title": "Registered nurses' experiences of working in the intensive care unit during the COVID-19 pandemic.", "authors": [{"family": "Bergman", "given": "Lina", "initials": "L"}, {"family": "Falk", "given": "Ann-Charlotte", "initials": "A"}, {"family": "Wolf", "given": "Axel", "initials": "A"}, {"family": "Larsson", "given": "Ing-Marie", "initials": "I"}], "type": "journal article", "published": "2021-05-10", "journal": {"title": "Nurs Crit Care", "issn": "1478-5153", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "During the pandemic, increased numbers of patients requiring intensive care unit (ICU) admission required an increase in ICU capacity, including ICU staffing with competence to care for critically ill patients. Consequently, nurses from acute care areas were called in to staff the ICU along with experienced intensive care nurses.\r\n\r\nTo describe Swedish registered nurses' experiences of caring for patients with COVID-19 in ICUs during the pandemic.\r\n\r\nMixed method survey design.\r\n\r\nAn online questionnaire was distributed through social media to registered nurses who had been working in the ICU during the COVID-19 outbreak. Data were collected for 1 week (May 2020) and analysed using content analysis and descriptive statistics.\r\n\r\nOf the 282 nurses who participated, the majority were ICU nurses (n = 151; 54%). Half of the nurses specialized in ICU reported that they were responsible for the ICU care of three or more patients during the pandemic (n = 75; 50%). Among non-intensive care nurses, only 19% received introduction to the COVID-19 ICU (n = 26). The analysis of data regarding nurses' experiences resulted in three categories: tumbling into chaos, diminished nursing care, and transition into pandemic ICU care. Participants described how patient safety and care quality were compromised, and that nursing care was severely deprioritized during the pandemic. The situation of not being able to provide nursing care resulted in ethical stress. Furthermore, an increased workload and worsened work environment affected nurses' health and well-being.\r\n\r\nThe findings from the present study indicate that nurses perceived that patient safety and quality of care were compromised during the pandemic. This resulted in ethical stress among nurses, which may have affected their physical and psychosocial well-being.\r\n\r\nThe COVID-19 pandemic had a severe impact on nurses' work environment, which could result in burnout and staff turnover.", "doi": "10.1111/nicc.12649", "pmid": "33973304", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:52:32.250Z", "modified": "2021-07-14T08:47:44.764Z"}, {"entity": "publication", "iuid": "8ce37febe6f44ed1a369d9b92a59e015", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ce37febe6f44ed1a369d9b92a59e015.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ce37febe6f44ed1a369d9b92a59e015"}}, "title": "National Swedish survey showed that child health services and routine immunisation programmes were resilient during the early COVID-19 pandemic.", "authors": [{"family": "Falkenstein Hagander", "given": "Kathy", "initials": "K"}, {"family": "Aronsson", "given": "Bernice", "initials": "B"}, {"family": "Danielsson", "given": "Madelene", "initials": "M"}, {"family": "Lepp", "given": "Tiia", "initials": "T"}, {"family": "Kulane", "given": "Asli", "initials": "A"}, {"family": "Schollin Ask", "given": "Lina", "initials": "L"}], "type": "journal article", "published": "2021-05-10", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": null, "issue": null, "issn-l": "0803-5253"}, "abstract": "Routine immunisation programmes are at risk of disruption due to the COVID-19 pandemic. This study aimed to investigate the resilience of the Swedish national immunisation programme for children up to the age of five years during the early stages of the pandemic.\n\nThis was a cross-sectional, web-based survey of regional child health offices in Sweden between 10 September and 9 October 2020. It explored the organisation of child health services during the early stages of the pandemic, focusing on routine child immunisation.\n\nAll 21 Swedish regional child health offices responded. They stated that child immunisation had been prioritised, communication with families had been intensified and there was greater flexibility at all organisational levels of child health services. In addition, the vaccine supply was sustained and child health centres remained open. However, there were periodic staff shortages, increased numbers of health visits cancelled by parents and most parent-education groups were paused.\n\nThe Swedish immunisation programme was resilient during the early COVID-19 pandemic, thanks to sustainable organisation co-ordinated by Sweden's network of regional child health offices.", "doi": "10.1111/apa.15912", "pmid": "33973264", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-05-17T18:53:22.196Z", "modified": "2021-05-17T18:54:07.082Z"}, {"entity": "publication", "iuid": "2a8f278f7ff54f37ae4a00a474cf4625", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2a8f278f7ff54f37ae4a00a474cf4625.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2a8f278f7ff54f37ae4a00a474cf4625"}}, "title": "Health literacy and changes in pattern of drug use among participants at the Stockholm Needle Exchange Program during the COVID-19 pandemic.", "authors": [{"family": "Lindqvist", "given": "K", "initials": "K"}, {"family": "Wallmofeldt", "given": "C", "initials": "C"}, {"family": "Holm\u00e9n", "given": "E", "initials": "E"}, {"family": "Hammarberg", "given": "A", "initials": "A"}, {"family": "K\u00e5berg", "given": "M", "initials": "M"}], "type": "journal article", "published": "2021-05-10", "journal": {"title": "Harm Reduct J", "issn": "1477-7517", "issn-l": null, "volume": "18", "issue": "1", "pages": "52"}, "abstract": "People who inject drugs may be particularly vulnerable to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) due to underlying health problems, stigma and social vulnerabilities. Harm reduction services, including needle exchange programs (NEP), have been subjected to varying degrees of disruption in the world, especially in the beginning of the coronavirus disease 2019 (COVID-19) pandemic. Compared to responses in other countries, Sweden's initial strategy toward limiting the spread and impact of COVID-19 was less restrictive to its citizens with no imposed general societal lockdown. In this study, we investigate changes in drug use patterns, utilization of NEP associated health services, COVID-19 health literacy and the prevalence of SARS-CoV-2 antibodies among NEP clients in Stockholm during the COVID-19 pandemic.\r\n\r\nNEP visits and services provided (needles/syringes, HIV and hepatitis C tests and treatment, naloxone distributed) and overall mortality among NEP clients between January 1 and October 31, 2020, were used for trend analyses in comparison with corresponding 2019 data. Between July 27 and October 2, 2020, NEP clients (n = 232) responded to a 27 item COVID-19 Health Literacy Questionnaire. SARS CoV-2 IgG antibody tests (n = 779) were performed between June 15 and October 31, 2020.\r\n\r\nDuring the COVID-19 pandemic number of clients, client visits, naloxone distribution and HCV tests remained stable compared to 2019, while distribution of needles/syringes increased (p < 0.0001); number of HIV tests and HCV treatments decreased (p < 0.05); and mortality decreased (< 0.01). Overall, the level of health literacy concerning transmission routes and protective measures was high. SARS-CoV-2 antibody prevalence was 5.4% (95% CI 4.0-7.2).\r\n\r\nThe Stockholm NEP managed to maintain a high level of clients and services during the pandemic. In general, COVID-19 health literacy was adequate and the overall SARS-CoV-2 antibody prevalence was low compared to the general population, which highlights a need for prioritized and targeted COVID-19 vaccination among PWID.", "doi": "10.1186/s12954-021-00499-z", "pmid": "33971892", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12954-021-00499-z"}, {"db": "pmc", "key": "PMC8107802"}], "notes": [], "created": "2021-05-17T18:59:08.075Z", "modified": "2021-07-14T08:50:00.818Z"}, {"entity": "publication", "iuid": "039f7f7aa71844cb935de8f4a197c76d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/039f7f7aa71844cb935de8f4a197c76d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/039f7f7aa71844cb935de8f4a197c76d"}}, "title": "Determinants of SARS-CoV-2 Impacts on Small-Scale Commercial Broiler Production Systems in Egypt: Implications for Mitigation Strategies.", "authors": [{"family": "Abu Hatab", "given": "Assem", "initials": "A"}, {"family": "Liu", "given": "Zhen", "initials": "Z"}, {"family": "Nasser", "given": "Asmaa", "initials": "A"}, {"family": "Esmat", "given": "Abourehab", "initials": "A"}], "type": "journal article", "published": "2021-05-10", "journal": {"title": "Animals (Basel)", "issn": "2076-2615", "volume": "11", "issue": "5", "issn-l": null}, "abstract": "As in many other countries, the outbreak of the COVID-19 pandemic, together with subsequent government containment measures, posed significant challenges to small-scale broiler production systems in Egypt. Based on a survey of 205 specialist small-scale commercial broiler farms (SCBFs) consisting of both farm-based and household-based production systems, this study identifies the primary pathways through which COVID-19 has affected SCBFs and investigates the determinants of farm perception of these effects. A polychoric principal component analysis sorted the effects of the pandemic on the SCBFs surveyed into five categories, namely, input availability, production and operational costs, labor and human resources, consumer demand and sales, and farm finances. Next, five ordered logit models were constructed to examine the determinants of the SCBFs' perception of each category of these effects. Generally, the empirical results revealed that COVID-19 affected SCBFs heterogeneously based on their management and production systems and resource endowment. Female-led and household-based SCBFs perceived significantly greater COVID-19 effects. In contrast, individually owned farms and those with membership of poultry producer organizations and larger total asset values perceived fewer effects. In addition, SCBFs operating in both local and provincial markets were less likely to perceive negative effects from the pandemic on their broiler farming activities. Although the adoption of strict and immediate containment measures was essential for controlling the virus and protecting public health, our results indicate that policy responses to COVID-19 must consider the likely effects on small businesses such as SCBFs since disruptions to such socioeconomically important supply chains will intensify human suffering from the pandemic. Overall, our findings provide important implications for the formulation of effective strategies for mitigating the impact of COVID-19 on small-scale broiler production systems in Egypt and enhancing their preparedness and resilience to future pandemics, natural hazard risks, and market shocks.", "doi": "10.3390/ani11051354", "pmid": "34068757", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ani11051354"}], "notes": [], "created": "2021-06-04T11:18:36.120Z", "modified": "2021-06-04T11:18:36.144Z"}, {"entity": "publication", "iuid": "e808459a76314069ba46438ca769f8c3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e808459a76314069ba46438ca769f8c3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e808459a76314069ba46438ca769f8c3"}}, "title": "A simple cognitive task intervention to prevent intrusive memories after trauma in patients in the Emergency Department: A randomized controlled trial terminated due to COVID-19.", "authors": [{"family": "Kanstrup", "given": "Marie", "initials": "M"}, {"family": "Singh", "given": "Laura", "initials": "L"}, {"family": "G\u00f6ransson", "given": "Katarina E", "initials": "KE"}, {"family": "Gamble", "given": "Beau", "initials": "B"}, {"family": "Taylor", "given": "Rod S", "initials": "RS"}, {"family": "Iyadurai", "given": "Lalitha", "initials": "L"}, {"family": "Moulds", "given": "Michelle L", "initials": "ML"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}], "type": "journal article", "published": "2021-05-10", "journal": {"title": "BMC Res Notes", "issn": "1756-0500", "volume": "14", "issue": "1", "pages": "176", "issn-l": null}, "abstract": "This randomised controlled trial (RCT) aimed to investigate the effects of a simple cognitive task intervention on intrusive memories (\"flashbacks\") and associated symptoms following a traumatic event. Patients presenting to a Swedish emergency department (ED) soon after a traumatic event were randomly allocated (1:1) to the simple cognitive task intervention (memory cue + mental rotation instructions + computer game \"Tetris\" for at least 20 min) or control (podcast, similar time). We planned follow-ups at one-week, 1-month, and where possible, 3- and 6-months post-trauma. Anticipated enrolment was N = 148.\n\nThe RCT was terminated prematurely after recruiting N = 16 participants. The COVID-19 pandemic prevented recruitment/testing in the ED because: (i) the study required face-to-face contact between participants, psychology researchers, ED staff, and patients, incurring risk of virus transmission; (ii) the host ED site received COVID-19 patients; and (iii) reduced flow of patients otherwise presenting to the ED in non-pandemic conditions (e.g. after trauma). We report on delivery of study procedures, recruitment, treatment adherence, outcome completion (primary outcome: number of intrusive memories during week 5), attrition, and limitations. The information presented and limitations may enable our group and others to learn from this terminated study. Trial registration ClinicalTrials.gov: NCT04185155 (04-12-2019).", "doi": "10.1186/s13104-021-05572-1", "pmid": "33971951", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13104-021-05572-1"}, {"db": "pmc", "key": "PMC8107806"}, {"db": "ClinicalTrials.gov", "key": "NCT04185155"}], "notes": [], "created": "2021-05-17T18:58:33.047Z", "modified": "2021-05-17T18:58:33.070Z"}, {"entity": "publication", "iuid": "bf5f0fa24fcf48df934cf1cd3aaaeb64", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf5f0fa24fcf48df934cf1cd3aaaeb64.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf5f0fa24fcf48df934cf1cd3aaaeb64"}}, "title": "Reasons for physician-related variability in end-of-life decision-making in intensive care.", "authors": [{"family": "Nordenskj\u00f6ld Syrous", "given": "Alma", "initials": "A"}, {"family": "Malmgren", "given": "Johan", "initials": "J"}, {"family": "Odenstedt Herg\u00e8s", "given": "Helena", "initials": "H"}, {"family": "Olausson", "given": "Sepideh", "initials": "S"}, {"family": "Kock-Redfors", "given": "Maria", "initials": "M"}, {"family": "\u00c5g\u00e5rd", "given": "Anders", "initials": "A"}, {"family": "Block", "given": "Linda", "initials": "L"}], "type": "journal article", "published": "2021-05-08", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "volume": null, "issue": null, "issn-l": "0001-5172"}, "abstract": "There is increasing evidence that the individual physician is the main factor influencing variability in end-of-life decision-making in intensive care units. End-of-life decisions are complex and should be adapted to each patient. Physician-related variability is problematic as it may result in unequal assessments that affect patient outcomes. The primary aim of this study was to investigate factors contributing to physician-related variability in end-of-life decision-making.\n\nThis is a qualitative sub-study of a previously conducted study. In-depth thematic analysis of semi-structured interviews with 19 critical care specialists from five different Swedish intensive care units was performed. Interviews took place between February 1, 2017, and May 31, 2017.\n\nFactors influencing physician-related variability consisted of different assessment of patient preferences, as well as intensivists' personality and values. Personality was expressed mainly through pace and determination in the decision-making process. Personal prejudices appeared in decisions, but few respondents had personally witnessed this. Avoidance of criticism and conflicts as well as individual strategies for emotional coping were other factors that influenced physician-related variability. Many respondents feared criticism for making their assessments, and the challenging nature of end-of-life decision-making lead to avoidance as well as emotional stress.\n\nVariability in end-of-life decision-making is an important topic that needs further investigation. It is imperative that such variability be acknowledged and addressed in a more formal and transparent manner. The ethical issues faced by intensivists have recently been compounded by the devastating impact of the COVID-19 pandemic, demonstrating in profound terms the importance of the topic.", "doi": "10.1111/aas.13842", "pmid": "33964009", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-17T19:08:32.486Z", "modified": "2021-05-17T19:08:32.496Z"}, {"entity": "publication", "iuid": "bb47ae65f9ac4973b315454f08f44804", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb47ae65f9ac4973b315454f08f44804.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb47ae65f9ac4973b315454f08f44804"}}, "title": "Corrigendum to: The influence of the SARS-CoV-2 pandemic on esophagogastric cancer services: an international survey of esophagogastric surgeons.", "authors": [{"family": "Kamarajah", "given": "Sivesh K", "initials": "SK"}, {"family": "Markar", "given": "Sheraz R", "initials": "SR"}, {"family": "Singh", "given": "Pritam", "initials": "P"}, {"family": "Griffiths", "given": "Ewen A", "initials": "EA"}, {"family": "Oesophagogastric Anastomosis Audit Group", "given": "", "initials": ""}], "type": "published erratum", "published": "2021-05-08", "journal": {"title": "Dis Esophagus", "issn": "1442-2050", "volume": null, "issue": null, "issn-l": "1120-8694"}, "abstract": null, "doi": "10.1093/dote/doab035", "pmid": "33963749", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "6272293"}], "notes": [], "created": "2021-05-17T19:07:32.983Z", "modified": "2021-05-17T19:08:00.109Z"}, {"entity": "publication", "iuid": "0fc45db4f8184778a5ff2740cd42ec6b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0fc45db4f8184778a5ff2740cd42ec6b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0fc45db4f8184778a5ff2740cd42ec6b"}}, "title": "Tumor Treating Fields for Glioblastoma Therapy During the COVID-19 Pandemic.", "authors": [{"family": "Gatson", "given": "Na Tosha N", "initials": "NTN"}, {"family": "Barnholtz-Sloan", "given": "Jill", "initials": "J"}, {"family": "Drappatz", "given": "Jan", "initials": "J"}, {"family": "Henriksson", "given": "Roger", "initials": "R"}, {"family": "Hottinger", "given": "Andreas F", "initials": "AF"}, {"family": "Hinoul", "given": "Piet", "initials": "P"}, {"family": "Kruchko", "given": "Carol", "initials": "C"}, {"family": "Puduvalli", "given": "Vinay K", "initials": "VK"}, {"family": "Tran", "given": "David D", "initials": "DD"}, {"family": "Wong", "given": "Eric T", "initials": "ET"}, {"family": "Glas", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2021-05-07", "journal": {"title": "Front Oncol", "issn": "2234-943X", "volume": "11", "issue": null, "pages": "679702", "issn-l": null}, "abstract": "The COVID-19 pandemic has placed excessive strain on health care systems and is especially evident in treatment decision-making for cancer patients. Glioblastoma (GBM) patients are among the most vulnerable due to increased incidence in the elderly and the short survival time. A virtual meeting was convened on May 9, 2020 with a panel of neuro-oncology experts with experience using Tumor Treating Fields (TTFields). The objective was to assess the risk-to-benefit ratio and provide guidance for using TTFields in GBM during the COVID-19 pandemic.\n\nTopics discussed included support and delivery of TTFields during the COVID-19 pandemic, concomitant use of TTFields with chemotherapy, and any potential impact of TTFields on the immune system in an intrinsically immunosuppressed GBM population. Special consideration was given to TTFields' use in elderly patients and in combination with radiotherapy regimens. Finally, the panel discussed the need to better capture data on COVID-19positive brain tumor patients to analyze longitudinal outcomes and changes in treatment decision-making during the pandemic.\n\nTTFields is a portable home-use device which can be managed via telemedicine and safely used in GBM patients during the COVID-19 pandemic. TTFields has no known immunosuppressive effects which is important during a crisis where other treatment methods might be limited, especially for elderly patients with multiple co-morbidities. It is too early to estimate the full impact of COVID-19 on the global healthcare system and on patient outcomes and the panel strongly recommended collaboration with existing cancer COVID-19 registries to follow CNS tumor patients.", "doi": "10.3389/fonc.2021.679702", "pmid": "34026655", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8139188"}], "notes": [], "created": "2021-05-29T16:22:39.733Z", "modified": "2021-05-29T16:22:39.744Z"}, {"entity": "publication", "iuid": "cd5dcd1a8c0947f2aa56016df442cd57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd5dcd1a8c0947f2aa56016df442cd57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd5dcd1a8c0947f2aa56016df442cd57"}}, "title": "How mobility restrictions policy and atmospheric conditions impacted air quality in the State of S\u00e3o Paulo during the COVID-19 outbreak.", "authors": [{"family": "Rudke", "given": "A P", "initials": "AP"}, {"family": "Martins", "given": "J A", "initials": "JA"}, {"family": "de Almeida", "given": "D S", "initials": "DS"}, {"family": "Martins", "given": "L D", "initials": "LD"}, {"family": "Beal", "given": "A", "initials": "A"}, {"family": "Hallak", "given": "R", "initials": "R"}, {"family": "Freitas", "given": "E D", "initials": "ED"}, {"family": "Andrade", "given": "M F", "initials": "MF"}, {"family": "Foroutan", "given": "H", "initials": "H"}, {"family": "Baek", "given": "B H", "initials": "BH"}, {"family": "de A Albuquerque", "given": "T T", "initials": "TT"}], "type": "journal article", "published": "2021-05-07", "journal": {"title": "Environ Res", "issn": "1096-0953", "volume": null, "issue": null, "pages": "111255", "issn-l": "0013-9351"}, "abstract": "Mobility restrictions are among actions to prevent the spread of the COVID-19 pandemic and have been pointed as reasons for improving air quality, especially in large cities. However, it is crucial to assess the impact of atmospheric conditions on air quality and air pollutant dispersion in the face of the potential variability of all sources. In this study, the impact of mobility restrictions on the air quality was analyzed for the most populous Brazilian State, S\u00e3o Paulo, severely impacted by COVID-19. Ground-based air quality data (PM 10, PM2.5, CO, SO2, NOx, NO2, NO, and O3) were used from 50 automatic air quality monitoring stations to evaluate the changes in concentrations before (January 01 - March 25) and during the partial quarantine (March 16 - June 30). Rainfall, fires, and daily cell phone mobility data were also used as supplementary information to the analyses. The Mann-Whitney U test was used to assess the heterogeneity of the air quality data during and before mobility restrictions. In general, the results demonstrated no substantial improvements in air quality for most of the pollutants when comparing before and during restrictions periods. Besides, when the analyzed period of 2020 is compared with the year 2019, there is no significant air quality improvement in the S\u00e3o Paulo State. However, special attention should be given to the Metropolitan Area of S\u00e3o Paulo (MASP), due to the vast population residing in this area and exposed to air pollution. The region reached an average decrease of 29% in CO, 28% in NOx, 40% in NO, 19% in SO2, 15% in PM2.5, and 8% in PM10 concentrations during the mobility restrictions period compared to the same period in 2019. The only pollutant that showed an increase in concentration was ozone, with a 20% increase compared to 2019 during the mobility restrictions period. Before the mobility restrictions period, the region reached an average decrease of 30% in CO, 39% in NOx, 63% in NO, 12% in SO2, 23% in PM2.5, 18% in PM10, and 16% in O3 concentrations when compared to the same period in 2019. On the other hand, Cubat\u00e3o, a highly industrialized area, showed statistically significant increases above 20% for most monitored pollutants in both periods of 2020 compared to 2019. This study reinforces that the main driving force of pollutant concentration variability is the dynamics of the atmosphere at its various time scales. An abnormal rainy season, with above average rainfall before the restrictions and below average after it, generated a scenario in which the probable significant reductions in emissions did not substantially affect the concentration of pollutants.", "doi": "10.1016/j.envres.2021.111255", "pmid": "33971134", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0013-9351(21)00549-1"}], "notes": [], "created": "2021-05-17T19:01:41.083Z", "modified": "2021-05-17T19:01:41.093Z"}, {"entity": "publication", "iuid": "d549138e93274c768eeb439c799261d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d549138e93274c768eeb439c799261d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d549138e93274c768eeb439c799261d0"}}, "title": "The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity.", "authors": [{"family": "Osuchowski", "given": "Marcin F", "initials": "MF"}, {"family": "Winkler", "given": "Martin S", "initials": "MS"}, {"family": "Skirecki", "given": "Tomasz", "initials": "T"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "Shankar-Hari", "given": "Manu", "initials": "M"}, {"family": "Lachmann", "given": "Gunnar", "initials": "G"}, {"family": "Monneret", "given": "Guillaume", "initials": "G"}, {"family": "Venet", "given": "Fabienne", "initials": "F"}, {"family": "Bauer", "given": "Michael", "initials": "M"}, {"family": "Brunkhorst", "given": "Frank M", "initials": "FM"}, {"family": "Weis", "given": "Sebastian", "initials": "S"}, {"family": "Garcia-Salido", "given": "Alberto", "initials": "A"}, {"family": "Kox", "given": "Matthijs", "initials": "M"}, {"family": "Cavaillon", "given": "Jean-Marc", "initials": "J"}, {"family": "Uhle", "given": "Florian", "initials": "F"}, {"family": "Weigand", "given": "Markus A", "initials": "MA"}, {"family": "Floh\u00e9", "given": "Stefanie B", "initials": "SB"}, {"family": "Wiersinga", "given": "W Joost", "initials": "WJ"}, {"family": "Almansa", "given": "Raquel", "initials": "R"}, {"family": "de la Fuente", "given": "Amanda", "initials": "A"}, {"family": "Martin-Loeches", "given": "Ignacio", "initials": "I"}, {"family": "Meisel", "given": "Christian", "initials": "C"}, {"family": "Spinetti", "given": "Thibaud", "initials": "T"}, {"family": "Schefold", "given": "Joerg C", "initials": "JC"}, {"family": "Cilloniz", "given": "Catia", "initials": "C"}, {"family": "Torres", "given": "Antoni", "initials": "A"}, {"family": "Giamarellos-Bourboulis", "given": "Evangelos J", "initials": "EJ"}, {"family": "Ferrer", "given": "Ricard", "initials": "R"}, {"family": "Girardis", "given": "Massimo", "initials": "M"}, {"family": "Cossarizza", "given": "Andrea", "initials": "A"}, {"family": "Netea", "given": "Mihai G", "initials": "MG"}, {"family": "van der Poll", "given": "Tom", "initials": "T"}, {"family": "Bermejo-Mart\u00edn", "given": "Jes\u00fas F", "initials": "JF"}, {"family": "Rubio", "given": "Ignacio", "initials": "I"}], "type": "journal article", "published": "2021-05-06", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "issn-l": "2213-2600", "volume": null, "issue": null, "pages": null}, "abstract": "The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with devastating consequences. While the medical community has gained insight into the epidemiology of COVID-19, important questions remain about the clinical complexities and underlying mechanisms of disease phenotypes. Severe COVID-19 most commonly involves respiratory manifestations, although other systems are also affected, and acute disease is often followed by protracted complications. Such complex manifestations suggest that SARS-CoV-2 dysregulates the host response, triggering wide-ranging immuno-inflammatory, thrombotic, and parenchymal derangements. We review the intricacies of COVID-19 pathophysiology, its various phenotypes, and the anti-SARS-CoV-2 host response at the humoral and cellular levels. Some similarities exist between COVID-19 and respiratory failure of other origins, but evidence for many distinctive mechanistic features indicates that COVID-19 constitutes a new disease entity, with emerging data suggesting involvement of an endotheliopathy-centred pathophysiology. Further research, combining basic and clinical studies, is needed to advance understanding of pathophysiological mechanisms and to characterise immuno-inflammatory derangements across the range of phenotypes to enable optimum care for patients with COVID-19.", "doi": "10.1016/S2213-2600(21)00218-6", "pmid": "33965003", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(21)00218-6"}, {"db": "pmc", "key": "PMC8102044"}], "notes": [], "created": "2021-05-17T19:08:57.517Z", "modified": "2021-05-17T19:09:49.278Z"}, {"entity": "publication", "iuid": "60a03d4e003f4e54a08b1e41bde1fc2d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60a03d4e003f4e54a08b1e41bde1fc2d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60a03d4e003f4e54a08b1e41bde1fc2d"}}, "title": "Old Overnight: Experiences of Age-Based Recommendations in Response to the COVID-19 Pandemic in Sweden.", "authors": [{"family": "Nilsson", "given": "Gabriella", "initials": "G"}, {"family": "Ekstam", "given": "Lisa", "initials": "L"}, {"family": "Axmon", "given": "Anna", "initials": "A"}, {"family": "Andersson", "given": "Janicke", "initials": "J"}], "type": "journal article", "published": "2021-05-06", "journal": {"title": "J Aging Soc Policy", "issn": "1545-0821", "issn-l": null, "volume": null, "issue": null, "pages": "1-21"}, "abstract": "The Swedish response to the COVID-19 pandemic included age-based recommendations of voluntary quarantine specifically for those 70 years of age or older. This paper investigates the experiences of a sudden change of policy in the form of an age restriction that trumped the contemporary active aging ideal. A web-based qualitative survey was conducted in April 2020. Through manual coding of a total of 851 responses, six different ways of relating to the age-based recommendations were identified. The results show that age is not an unproblematic governing principle. Instead, in addition to protecting a vulnerable group, the age-based recommendation meant deprivation of previously assigned individual responsibility and, consequently, autonomy. It is shown how respondents handled this tension through varying degrees of compliance and resistance. Findings highlight the importance of continuously tracking the long-term consequences of age-based policy to avoid negative self-image and poorer health among older adults.", "doi": "10.1080/08959420.2021.1925042", "pmid": "34010122", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-05-20T14:37:14.738Z", "modified": "2021-07-14T08:26:56.251Z"}, {"entity": "publication", "iuid": "db3b2d224a54435bad4d993f3797ac03", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db3b2d224a54435bad4d993f3797ac03.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db3b2d224a54435bad4d993f3797ac03"}}, "title": "International transfers of personal data for health research following Schrems II: a problem in need of a solution.", "authors": [{"family": "Hallinan", "given": "Dara", "initials": "D"}, {"family": "Bernier", "given": "Alexander", "initials": "A"}, {"family": "Cambon-Thomsen", "given": "Anne", "initials": "A"}, {"family": "Crawley", "given": "Francis P", "initials": "FP"}, {"family": "Dimitrova", "given": "Diana", "initials": "D"}, {"family": "Medeiros", "given": "Claudia Bauzer", "initials": "CB"}, {"family": "Nilsonne", "given": "Gustav", "initials": "G"}, {"family": "Parker", "given": "Simon", "initials": "S"}, {"family": "Pickering", "given": "Brian", "initials": "B"}, {"family": "Rennes", "given": "St\u00e9phanie", "initials": "S"}], "type": "journal article", "published": "2021-05-06", "journal": {"title": "Eur J Hum Genet", "issn": "1476-5438", "volume": null, "issue": null, "issn-l": null}, "abstract": "On 16 July 2020, the Court of Justice of the European Union issued their decision in the Schrems II case concerning Facebook's transfers of personal data from the EU to the US. The decision may have significant effects on the legitimate transfer of personal data for health research purposes from the EU. This article aims: (i) to outline the consequences of the Schrems II decision for the sharing of personal data for health research between the EU and third countries, particularly in the context of the COVID-19 pandemic; and, (ii) to consider certain options available to address the consequences of the decision and to facilitate international data exchange for health research moving forward.", "doi": "10.1038/s41431-021-00893-y", "pmid": "33953344", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41431-021-00893-y"}, {"db": "pmc", "key": "PMC8099706"}], "notes": [], "created": "2021-05-17T19:04:18.502Z", "modified": "2021-05-17T19:04:35.741Z"}, {"entity": "publication", "iuid": "8afa2e52f9f84ccc9077e945af9211de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8afa2e52f9f84ccc9077e945af9211de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8afa2e52f9f84ccc9077e945af9211de"}}, "title": "Dying from COVID-19 in nursing homes-sex differences in symptom occurrence.", "authors": [{"family": "Martinsson", "given": "Lisa", "initials": "L"}, {"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "Bergstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Staffan", "initials": "S"}], "type": "journal article", "published": "2021-05-06", "journal": {"title": "BMC Geriatr", "issn": "1471-2318", "volume": "21", "issue": "1", "pages": "294", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19), is a disease with diverse presentation. Several studies have shown different occurrence of symptoms for women and men, but no studies have been found examining sex differences in clinical presentation for nursing home residents dying from COVID-19. The objective of this study was to describe sex and age differences and the impact of a dementia diagnosis on symptom occurrence during the last week in life for persons dying from COVID-19 in nursing homes.\n\nThis is a population-based retrospective study based on data from the Swedish Register of Palliative Care. A total of 1994 residents aged 65 or older who died from COVID-19 in nursing homes were identified. The impact of sex, age and a dementia diagnosis on six different symptoms was analysed using chi2-test and multivariate logistic regression.\n\nResidents dying from COVID-19 were more often men (p < .002). Men more often had dyspnoea and death rattles (p < .001). Nausea was more common in women (p < .001). No sex differences in the occurrence of pain, anxiety or confusion were seen. Dyspnoea and nausea were less commonly reported in residents with dementia (p < .001).\n\nWe found sex differences in symptom presentation for fatal COVID-19 in nursing home settings which remained after adjusting for age. Residents with a dementia diagnosis had fewer symptoms reported before death compared to those without dementia. Clinical presentation of fatal COVID-19 differs between women and men in nursing homes. Residents with fatal COVID-19 present with more unspecific and less prominent symptoms when also suffering from dementia.", "doi": "10.1186/s12877-021-02228-4", "pmid": "33957890", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12877-021-02228-4"}, {"db": "pmc", "key": "PMC8100361"}], "notes": [], "created": "2021-05-17T19:06:20.921Z", "modified": "2021-05-17T19:06:20.931Z"}, {"entity": "publication", "iuid": "935b8ada86fb4f158abf4c9e4ff4e452", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/935b8ada86fb4f158abf4c9e4ff4e452.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/935b8ada86fb4f158abf4c9e4ff4e452"}}, "title": "Comparison of Immunological Profiles of SARS-CoV-2 Variants in the COVID-19 Pandemic Trends: An Immunoinformatics Approach.", "authors": [{"family": "Mallavarpu Ambrose", "given": "Jenifer", "initials": "J"}, {"family": "Priya Veeraraghavan", "given": "Vishnu", "initials": "V"}, {"family": "Kullappan", "given": "Malathi", "initials": "M"}, {"family": "Chellapandiyan", "given": "Poongodi", "initials": "P"}, {"family": "Krishna Mohan", "given": "Surapaneni", "initials": "S"}, {"family": "Manivel", "given": "Vivek Anand", "initials": "VA"}], "type": "journal article", "published": "2021-05-06", "journal": {"title": "Antibiotics (Basel)", "issn": "2079-6382", "volume": "10", "issue": "5", "issn-l": null}, "abstract": "The current dynamics of the COVID-19 pandemic have become a serious concern with the emergence of a series of mutant variants of the SARS-CoV-2 virus. Unlike the previous strain, it is reported that the descendants are associated with increased risk of transmission yet causing less impact in terms of hospital admission, the severity of illness, or mortality. Moreover, the vaccine efficacy is also not believed to vary among the population depending on the variants of the virus and ethnicity. It has been determined that the mutations recorded in the spike gene and protein of the newly evolved viruses are specificallyresponsible for this transformation in the behavior of the virus and its disease condition. Hence, this study aimed to compare the immunogenic profiles of the spike protein from the latest variants of the SARS-CoV-2 virus concerning the probability of COVID-19 severity. Genome sequences of the latest SARS-CoV-2 variants were obtained from GISAID and NCBI repositories. The translated protein sequences were run against T-cell and B-cell epitope prediction tools. Subsequently, antigenicity, immunogenicity, allergenicity, toxicity, and conservancy of the identified epitopes were ascertained using various prediction servers. Only the non-allergic and non-toxic potential epitopes were matched for population relevance by using the Human Leucocyte Antigen population registry in IEDB. Finally, the selected epitopes were validated by docking and simulation studies. The evaluated immunological parameters would concurrently reveal the severity of COVID-19, determining the infection rate of the pathogen. Our immunoinformatics approach disclosed that spike protein of the five variants was capable of forming potential T and B-cell epitopes with varying immune responses. Although the Wuhan strain showed a high number of epitope/HLA combinations, relatively less antigenicity and higher immunogenicity results in poor neutralizing capacity, which could be associated with increased disease severity. Our data demonstrate that increased viral antigenicity with moderate to high immunogenicity, and several potential epitope/HLA combinations in England strain, the USA, India, and South Africa variants, could possess a high neutralizing ability. Therefore, our findings reinforce that the newly circulating variants of SARS-CoV-2 might be associated with more infectiousness and less severe disease condition despite their greater viremia, as reported in the recent COVID-19 cases, whichconsequently determine their increased epidemiological fitness.", "doi": "10.3390/antibiotics10050535", "pmid": "34066389", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "antibiotics10050535"}], "notes": [], "created": "2021-06-04T11:21:05.121Z", "modified": "2021-06-04T11:21:21.712Z"}, {"entity": "publication", "iuid": "8ffd2261bef943428c8755ef205b6cb9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ffd2261bef943428c8755ef205b6cb9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ffd2261bef943428c8755ef205b6cb9"}}, "title": "Assessing the consequences of quarantines during a pandemic.", "authors": [{"family": "Forslid", "given": "Rikard", "initials": "R"}, {"family": "Herzing", "given": "Mathias", "initials": "M"}], "type": "journal article", "published": "2021-05-06", "journal": {"title": "Eur J Health Econ", "issn": "1618-7601", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "This paper analyzes the epidemiological and economic effects of quarantines. We use a basic epidemiological model, a SEIR-model, that is calibrated to roughly resemble the COVID-19 pandemic, and we assume that individuals that become infected or are isolated on average lose a share of their productivity. An early quarantine postpones but does not alter the course of the pandemic at a cost that increases in the duration and the extent of the quarantine. For quarantines at later stages of the pandemic there is a trade-off between lowering the peak level of infectious people on the one hand and minimizing fatalities and economic losses on the other hand. A longer quarantine dampens the peak level of infectious people and also reduces the total number of infected persons but increases economic losses. Both the peak level of infectious individuals and the total share of the population that will have been infected are U-shaped in relation to the share of the population in quarantine, while economic costs increase in this share. In particular, a quarantine covering a moderate share of the population leads to a lower peak, fewer deaths and lower economic costs, but it implies that the peak of the pandemic occurs earlier.", "doi": "10.1007/s10198-021-01310-3", "pmid": "33956249", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10198-021-01310-3"}, {"db": "pmc", "key": "PMC8100945"}], "notes": [], "created": "2021-05-17T19:04:55.024Z", "modified": "2021-07-14T08:24:40.283Z"}, {"entity": "publication", "iuid": "3794415570724752b202ae478473faa3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3794415570724752b202ae478473faa3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3794415570724752b202ae478473faa3"}}, "title": "Microvascular Dysfunction in Patients with Critical COVID-19, A Pilot Study.", "authors": [{"family": "Tehrani", "given": "Sara", "initials": "S"}, {"family": "Gille-Johnson", "given": "Patrik", "initials": "P"}], "type": "journal article", "published": "2021-05-04", "journal": {"title": "Shock", "issn": "1540-0514", "volume": null, "issue": null, "issn-l": null}, "abstract": "Endothelial and microvascular dysfunction may be a key pathogenic feature of severe COVID-19. The aim of this study was to investigate endothelial-dependent and endothelial-independent skin microvascular reactivity in patients with critical COVID-19.\n\nTwelve patients with COVID-19 treated with non-invasive or invasive mechanical ventilation were included in the study. We investigated skin microvascular reactivity on two separate days during hospitalization (study day 1 and 2) and at least three months after disease onset (study day 3). Twelve controls with no confirmed or suspected COVID-19 infection during 2020 were also examined. Skin perfusion was investigated through Laser Speckle Contrast Imaging (LSCI) before and after iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP) to determine the endothelial-dependent and the endothelial-independent vasodilation, respectively.\n\nCompared to controls, patients with critical COVID-19 had higher basal skin perfusion and reduced responses to endothelial-dependent (ACh, p = 0.002) and endothelial-independent (SNP, p = 0.01) vasodilator drugs on study day 1. In addition, the ACh/SNP ratio was significantly reduced in patients (0.50 \u00b1 0.36 versus 0.91 \u00b1 0.49 in controls, p = 0.02). Three months after disease onset, surviving patients tended to have reduced ACh-mediated vasodilation compared to controls (p = 0.08).\n\nThis small-sized pilot study demonstrates that critical COVID-19 infection is associated with microvascular impairment and, in particular, a markedly reduced endothelial function. Our results also suggest that microvascular function may not be fully recovered three months after disease onset.", "doi": "10.1097/SHK.0000000000001803", "pmid": "33958544", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00024382-900000000-97251"}], "notes": [], "created": "2021-05-17T19:06:47.746Z", "modified": "2021-05-17T19:06:47.768Z"}, {"entity": "publication", "iuid": "449ea5b1c2084fbeb52732384922e8cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/449ea5b1c2084fbeb52732384922e8cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/449ea5b1c2084fbeb52732384922e8cb"}}, "title": "Hairy cell leukemia and COVID-19 adaptation of treatment guidelines.", "authors": [{"family": "Grever", "given": "Michael", "initials": "M"}, {"family": "Andritsos", "given": "Leslie", "initials": "L"}, {"family": "Banerji", "given": "Versha", "initials": "V"}, {"family": "Barrientos", "given": "Jacqueline C", "initials": "JC"}, {"family": "Bhat", "given": "Seema", "initials": "S"}, {"family": "Blachly", "given": "James S", "initials": "JS"}, {"family": "Call", "given": "Timothy", "initials": "T"}, {"family": "Cross", "given": "Matthew", "initials": "M"}, {"family": "Dearden", "given": "Claire", "initials": "C"}, {"family": "Demeter", "given": "Judit", "initials": "J"}, {"family": "Dietrich", "given": "Sasha", "initials": "S"}, {"family": "Falini", "given": "Brunangelo", "initials": "B"}, {"family": "Forconi", "given": "Francesco", "initials": "F"}, {"family": "Gladstone", "given": "Douglas E", "initials": "DE"}, {"family": "Gozzetti", "given": "Alessandro", "initials": "A"}, {"family": "Iyengar", "given": "Sunil", "initials": "S"}, {"family": "Johnston", "given": "James B", "initials": "JB"}, {"family": "Juliusson", "given": "Gunnar", "initials": "G"}, {"family": "Kraut", "given": "Eric", "initials": "E"}, {"family": "Kreitman", "given": "Robert J", "initials": "RJ"}, {"family": "Lauria", "given": "Francesco", "initials": "F"}, {"family": "Lozanski", "given": "Gerard", "initials": "G"}, {"family": "Parikh", "given": "Sameer A", "initials": "SA"}, {"family": "Park", "given": "Jae", "initials": "J"}, {"family": "Polliack", "given": "Aaron", "initials": "A"}, {"family": "Ravandi", "given": "Farhad", "initials": "F"}, {"family": "Robak", "given": "Tadeusz", "initials": "T"}, {"family": "Rogers", "given": "Kerry A", "initials": "KA"}, {"family": "Saven", "given": "Alan", "initials": "A"}, {"family": "Seymour", "given": "John F", "initials": "JF"}, {"family": "Tadmor", "given": "Tamar", "initials": "T"}, {"family": "Tallman", "given": "Martin S", "initials": "MS"}, {"family": "Tam", "given": "Constantine S", "initials": "CS"}, {"family": "Tiacci", "given": "Enrico", "initials": "E"}, {"family": "Troussard", "given": "Xavier", "initials": "X"}, {"family": "Zent", "given": "Clive", "initials": "C"}, {"family": "Zenz", "given": "Thorsten", "initials": "T"}, {"family": "Zinzani", "given": "Pier Luigi", "initials": "PL"}, {"family": "W\u00f6rmann", "given": "Bernhard", "initials": "B"}], "type": "journal article", "published": "2021-05-04", "journal": {"title": "Leukemia", "issn": "1476-5551", "volume": null, "issue": null, "issn-l": null}, "abstract": "Standard treatment options in classic HCL (cHCL) result in high response rates and near normal life expectancy. However, the disease itself and the recommended standard treatment are associated with profound and prolonged immunosuppression, increasing susceptibility to infections and the risk for a severe course of COVID-19. The Hairy Cell Leukemia Foundation (HCLF) has recently convened experts and discussed different clinical strategies for the management of these patients. The new recommendations adapt the 2017 consensus for the diagnosis and management with cHCL to the current COVID-19 pandemic. They underline the option of active surveillance in patients with low but stable blood counts, consider the use of targeted and non-immunosuppressive agents as first-line treatment for cHCL, and give recommendations on preventive measures against COVID-19.", "doi": "10.1038/s41375-021-01257-7", "pmid": "33947938", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41375-021-01257-7"}], "notes": [], "created": "2021-05-06T05:52:53.609Z", "modified": "2021-05-06T05:52:53.635Z"}, {"entity": "publication", "iuid": "c60e9460c17a4c23a2bc424aa1029baa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c60e9460c17a4c23a2bc424aa1029baa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c60e9460c17a4c23a2bc424aa1029baa"}}, "title": "Multi-omics reveals age-related differences in the diaphragm response to mechanical ventilation: a pilot study.", "authors": [{"family": "Lyu", "given": "Qiong", "initials": "Q"}, {"family": "Wen", "given": "Ya", "initials": "Y"}, {"family": "Zhang", "given": "Xiang", "initials": "X"}, {"family": "Addinsall", "given": "Alex B", "initials": "AB"}, {"family": "Cacciani", "given": "Nicola", "initials": "N"}, {"family": "Larsson", "given": "Lars", "initials": "L", "orcid": "0000-0003-3722-035X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5f02065531945db928529767189a083.json"}}], "type": "comparative study", "published": "2021-05-03", "journal": {"title": "Skeletal Muscle", "issn": "2044-5040", "issn-l": null, "volume": "11", "issue": "1", "pages": "11"}, "abstract": "Old age is associated with a significantly increased mortality in COVID-19 patients exposed to long-term controlled mechanical ventilation (CMV) and suggested to be due to the hyperinflammatory response associated with the viral infection. However, our understanding of age-related differences in the response to CMV in the absence of a viral infection remains insufficient.\n\nYoung (7-8 months) and old (28-32 months) F344 BN hybrid rats were exposed to the ICU condition for 5 days, i.e., complete immobilization, mechanical ventilation, and extensive monitoring. Transcriptomic (RNA-Seq) and proteomics (Proximity Extension Assay) analyses of the diaphragm and proteomics analysis of plasma were conducted to investigate the molecular differences between young and old rats exposed to the ICU condition.\n\nAccording to multi-omics analyses, significant differences were observed in the diaphragm between young and old rats in response to 5 days CMV and immobilization. In young rats, metabolic pathways were primarily downregulated in response to immobilization (post-synaptic blockade of neuromuscular transmission). In old rats, on the other hand, dramatic immune and inflammatory responses were observed, i.e., an upregulation of specific related pathways such as \"IL-17 signaling pathway\", along with a higher level of inflammatory factors and cytokine/chemokine in plasma.\n\nThe dramatically increased mortality in old ICU patients with COVID-19-associated hyperinflammation and cytokine storm need not only reflect the viral infection but may also be associated with the ventilator induced diaphragm dysfunction (VIDD) and hyperinflammatory responses induced by long-term CMV per se. Although mechanical ventilation is a life-saving intervention in COVID-19 ICU patients, CMV should be cautiously used especially in old age and other means of respiratory support may be considered, such as negative pressure ventilation.", "doi": "10.1186/s13395-021-00267-4", "pmid": "33941271", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13395-021-00267-4"}, {"db": "pmc", "key": "PMC8089133"}], "notes": [], "created": "2021-05-04T15:55:44.955Z", "modified": "2021-06-10T11:24:48.982Z"}, {"entity": "publication", "iuid": "d1f06bd2922e4bbbbedc6a1fd11f2401", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1f06bd2922e4bbbbedc6a1fd11f2401.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1f06bd2922e4bbbbedc6a1fd11f2401"}}, "title": "Knowledge and preventive behaviors regarding COVID-19 in Bangladesh: A nationwide distribution", "authors": [{"family": "Hosen", "given": "Ismail", "initials": "I"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Sakib", "given": "Najmuj", "initials": "N"}, {"family": "Hussain", "given": "Nur", "initials": "N"}, {"family": "al Mamun", "given": "Firoj", "initials": "F"}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA"}], "type": "journal-article", "published": "2021-05-03", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "5", "pages": "e0251151"}, "abstract": null, "doi": "10.1371/journal.pone.0251151", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.7910/DVN/YKH9C1", "description": "Dataset: socio-demographic characteristics,  sources from where participants get information regarding COVID-19, participants\u2019 knowledge concerning COVID-19, participants\u2019 behavior in preventing COVID-19 etc."}], "notes": [], "created": "2021-05-04T15:56:57.740Z", "modified": "2021-07-14T08:38:09.031Z"}, {"entity": "publication", "iuid": "8cdc3bccc3c8411e8e40b47d294ea43a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8cdc3bccc3c8411e8e40b47d294ea43a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8cdc3bccc3c8411e8e40b47d294ea43a"}}, "title": "False Positive Results in SARS-CoV-2 Serological Tests for Samples From Patients With Chronic Inflammatory Diseases", "authors": [{"family": "Kharlamova", "given": "Nastya", "initials": "N"}, {"family": "Dunn", "given": "Nicky", "initials": "N"}, {"family": "Bedri", "given": "Sahl K", "initials": "SK"}, {"family": "Jerling", "given": "Svante", "initials": "S"}, {"family": "Almgren", "given": "Malin", "initials": "M"}, {"family": "Faustini", "given": "Francesca", "initials": "F"}, {"family": "Gunnarsson", "given": "Iva", "initials": "I"}, {"family": "R\u00f6nnelid", "given": "Johan", "initials": "J"}, {"family": "Pullerits", "given": "Rille", "initials": "R"}, {"family": "Gjertsson", "given": "Inger", "initials": "I"}, {"family": "Lundberg", "given": "Karin", "initials": "K"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Fink", "given": "Katharina", "initials": "K"}, {"family": "Fogdell-Hahn", "given": "Anna", "initials": "A"}], "type": "journal-article", "published": "2021-05-03", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "12", "issue": null, "pages": "666114"}, "abstract": "Patients with chronic inflammatory diseases are often treated with immunosuppressants and therefore are of particular concern during the SARS-CoV-2 pandemic. Serological tests will improve our understanding of the infection and immunity in this population, unless they tests give false positive results. The aim of this study was to evaluate the specificity of SARS-Cov-2 serological assays using samples from patients with chronic inflammatory diseases collected prior to April 2019, thus defined as negative. Samples from patients with multiple sclerosis (MS, n=10), rheumatoid arthritis (RA, n=47) with or without rheumatoid factor (RF) and/or anti-cyclic citrullinated peptide antibodies (anti-CCP2) and systemic lupus erythematosus (SLE, n=10) with or without RF, were analyzed for SARS-CoV-2 antibodies using 17 commercially available lateral flow assays (LFA), two ELISA kits and one in-house developed IgG multiplex bead-based assay. Six LFA and the in-house validated IgG assay correctly produced negative results for all samples. However, the majority of assays (n=13), gave false positive signal for samples from patients with RA and SLE. This was most notable in samples from RF positive RA patients. No false positive samples were detected in any assay using samples from patients with MS. Poor specificity of commercial serological assays could possibly be, at least partly, due to interfering antibodies in samples from patients with chronic inflammatory diseases. For these patients, the risk of false positivity should be considered when interpreting results of the SARS-CoV-2 serological assays.", "doi": "10.3389/fimmu.2021.666114", "pmid": "34012450", "labels": {"Type: Journal article": null, "Funder: Vinnova": null, "Category: Serology": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8126683"}, {"db": "URL", "key": "https://doi.org/10.3389/fimmu.2021.666114.s001", "description": "False Positive Results in SARS-CoV-2 Serological Tests for Samples From Patients With Chronic Inflammatory Diseases"}], "notes": [], "created": "2021-05-21T17:22:04.614Z", "modified": "2021-11-19T11:29:29.703Z"}, {"entity": "publication", "iuid": "9f36b274935a454b82985f1686c1cf90", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f36b274935a454b82985f1686c1cf90.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f36b274935a454b82985f1686c1cf90"}}, "title": "COVID-19 and ANCA-associated vasculitis \u2013 recommendations for vaccine preparedness and the use of rituximab", "authors": [{"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Alberici", "given": "Federico", "initials": "F"}, {"family": "Fervenza", "given": "Fernando C", "initials": "FC"}, {"family": "Jayne", "given": "David R W", "initials": "DRW"}, {"family": "Segelmark", "given": "M\u00e5rten", "initials": "M"}, {"family": "Tesar", "given": "Vladimir", "initials": "V"}, {"family": "Szpirt", "given": "Wladimir M", "initials": "WM"}], "type": "journal-article", "published": "2021-05-03", "journal": {"title": "Nephrol Dial Transplant", "issn": "0931-0509", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1093/ndt/gfab174", "pmid": null, "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-05T05:25:35.500Z", "modified": "2021-05-05T05:25:35.513Z"}, {"entity": "publication", "iuid": "1dd2c1d420b74b8c96ee17f2ba351e6c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1dd2c1d420b74b8c96ee17f2ba351e6c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1dd2c1d420b74b8c96ee17f2ba351e6c"}}, "title": "A urinary peptidomic profile predicts outcome in SARS-CoV-2-infected patients.", "authors": [{"family": "Wendt", "given": "Ralph", "initials": "R"}, {"family": "Thijs", "given": "Lutgarde", "initials": "L"}, {"family": "Kalbitz", "given": "Sven", "initials": "S"}, {"family": "Mischak", "given": "Harald", "initials": "H"}, {"family": "Siwy", "given": "Justyna", "initials": "J"}, {"family": "Raad", "given": "Julia", "initials": "J"}, {"family": "Metzger", "given": "Jochen", "initials": "J"}, {"family": "Neuhaus", "given": "Barbara", "initials": "B"}, {"family": "Leyen", "given": "Heiko von der", "initials": "HV"}, {"family": "Dudoignon", "given": "Emmanuel", "initials": "E"}, {"family": "Mebazaa", "given": "Alexandre", "initials": "A"}, {"family": "Spasovski", "given": "Goce", "initials": "G"}, {"family": "Milenkova", "given": "Mimoza", "initials": "M"}, {"family": "Canevska-Talevska", "given": "Aleksandra", "initials": "A"}, {"family": "Czerwie\u0144ska", "given": "Beata", "initials": "B"}, {"family": "Wiecek", "given": "Andrzej", "initials": "A"}, {"family": "Peters", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Nilsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Schwab", "given": "Matthias", "initials": "M"}, {"family": "Rothfuss", "given": "Katja", "initials": "K"}, {"family": "L\u00fcbbert", "given": "Christoph", "initials": "C"}, {"family": "Staessen", "given": "Jan A", "initials": "JA"}, {"family": "Beige", "given": "Joachim", "initials": "J"}, {"family": "CRIT-COV-U investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-03", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": null, "issue": null, "pages": "100883", "issn-l": null}, "abstract": "COVID-19 prediction models based on clinical characteristics, routine biochemistry and imaging, have been developed, but little is known on proteomic markers reflecting the molecular pathophysiology of disease progression.\n\nhe multicentre (six European study sites) Prospective Validation of a Proteomic Urine Test for Early and Accurate Prognosis of Critical Course Complications in Patients with SARS-CoV-2 Infection Study (Crit-COV-U) is recruiting consecutive patients (\u2265 18 years) with PCR-confirmed SARS-CoV-2 infection. A urinary proteomic biomarker (COV50) developed by capillary-electrophoresis-mass spectrometry (CE-MS) technology, comprising 50 sequenced peptides and identifying the parental proteins, was evaluated in 228 patients (derivation cohort) with replication in 99 patients (validation cohort). Death and progression along the World Health Organization (WHO) Clinical Progression Scale were assessed up to 21 days after the initial PCR test. Statistical methods included logistic regression, receiver operating curve (ROC) analysis and comparison of the area under the curve (AUC).\n\nin the derivation cohort, 23 patients died, and 48 developed worse WHO scores. The odds ratios (OR) for death per 1 standard deviation (SD) increment in COV50 were 3\u00b752 (95% CI, 2\u00b702-6\u00b713, p <0\u00b70001) unadjusted and 2\u00b773 (1\u00b725-5\u00b795, p = 0\u00b7012) adjusted for sex, age, baseline WHO score, body mass index (BMI) and comorbidities. For WHO scale progression, the corresponding OR were 2\u00b763 (1\u00b780-3\u00b785, p<0\u00b70001) and 3\u00b738 (1\u00b785-6\u00b717, p<0\u00b70001), respectively. The area under the curve (AUC) for COV50 as a continuously distributed variable was 0\u00b780 (0\u00b772-0\u00b788) for mortality and 0\u00b774 (0\u00b766-0\u00b781) for worsening WHO score. The optimised COV50 thresholds for mortality and worsening WHO score were 0\u00b747 and 0\u00b704 with sensitivity/specificity of 87\u00b70 (74\u00b76%) and 77\u00b71 (63\u00b79%), respectively. On top of covariates, COV50 improved the AUC, albeit borderline for death, from 0\u00b778 to 0\u00b782 (p = 0\u00b711) and 0\u00b784 (p = 0\u00b7052) for mortality and from 0\u00b768 to 0\u00b778 (p = 0\u00b70097) and 0\u00b775 (p = 0\u00b7021) for worsening WHO score. The validation cohort findings were confirmatory.\n\nthis first CRIT-COV-U report proves the concept that urinary proteomic profiling generates biomarkers indicating adverse COVID-19 outcomes, even at an early disease stage, including WHO stages 1-3. These findings need to be consolidated in an upcoming final dataset.", "doi": "10.1016/j.eclinm.2021.100883", "pmid": "33969282", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(21)00163-2"}, {"db": "pmc", "key": "PMC8092440"}], "notes": [], "created": "2021-05-17T18:39:24.579Z", "modified": "2021-05-17T19:02:55.993Z"}, {"entity": "publication", "iuid": "f7ab08cba0a74716b976aaa57be82009", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7ab08cba0a74716b976aaa57be82009.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7ab08cba0a74716b976aaa57be82009"}}, "title": "Recent advances on smart glycoconjugate vaccines in infections and cancer.", "authors": [{"family": "Anderluh", "given": "Marko", "initials": "M"}, {"family": "Berti", "given": "Francesco", "initials": "F"}, {"family": "Bzducha-Wr\u00f3bel", "given": "Anna", "initials": "A"}, {"family": "Chiodo", "given": "Fabrizio", "initials": "F"}, {"family": "Colombo", "given": "Cinzia", "initials": "C"}, {"family": "Compostella", "given": "Federica", "initials": "F"}, {"family": "Durlik", "given": "Katarzyna", "initials": "K"}, {"family": "Ferhati", "given": "Xhenti", "initials": "X"}, {"family": "Holmdahl", "given": "Rikard", "initials": "R"}, {"family": "Jovanovic", "given": "Dragana", "initials": "D"}, {"family": "Kaca", "given": "Wieslaw", "initials": "W"}, {"family": "Lay", "given": "Luigi", "initials": "L"}, {"family": "Marinovic-Cincovic", "given": "Milena", "initials": "M"}, {"family": "Marradi", "given": "Marco", "initials": "M"}, {"family": "Ozil", "given": "Musa", "initials": "M"}, {"family": "Polito", "given": "Laura", "initials": "L"}, {"family": "Reina", "given": "Jos\u00e8 Juan", "initials": "JJ"}, {"family": "Reis", "given": "Celso A", "initials": "CA"}, {"family": "Sackstein", "given": "Robert", "initials": "R"}, {"family": "Silipo", "given": "Alba", "initials": "A"}, {"family": "\u0160vajger", "given": "Urban", "initials": "U"}, {"family": "Van\u011bk", "given": "Ond\u0159ej", "initials": "O"}, {"family": "Yamamoto", "given": "Fumiichiro", "initials": "F"}, {"family": "Richichi", "given": "Barbara", "initials": "B"}, {"family": "van Vliet", "given": "Sandra J", "initials": "SJ"}], "type": "journal article", "published": "2021-05-02", "journal": {"title": "FEBS J", "issn": "1742-4658", "volume": null, "issue": null, "issn-l": null}, "abstract": "Vaccination is one of the greatest achievements in biomedical research preventing death and morbidity in many infectious diseases through the induction of pathogen-specific humoral and cellular immune responses. Currently, no effective vaccines are available for pathogens with a highly variable antigenic load, such as the Human Immunodeficiency Virus or to induce cellular T cell immunity in the fight against cancer. The recent SARS-CoV-2 outbreak has reinforced the relevance of designing smart therapeutic vaccine modalities to ensure public health. Indeed, academic and private companies have ongoing joint efforts to develop novel vaccine prototypes for this virus. Many pathogens are covered by a dense glycan-coat, which form an attractive target for vaccine development. Moreover, many tumor types are characterized by altered glycosylation profiles that are known as 'tumor-associated carbohydrate antigens' (TACA). Unfortunately, glycans do not provoke a vigorous immune response and generally serve as T cell-independent antigens, not eliciting protective IgG responses nor inducing immunological memory. A close and continuous crosstalk between glycochemists and glycoimmunologists is essential for the successful development of efficient immune modulators. It is clear that this is a key point for the discovery of novel approaches, which could significantly improve our understanding of the immune system. In this review, we discuss the latest advancements in development of vaccines against glycan epitopes to gain selective immune responses, and to provide an overview on the role of different immunogenic constructs in improving glycovaccine efficacy.", "doi": "10.1111/febs.15909", "pmid": "33934527", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-05-04T16:00:22.998Z", "modified": "2021-05-04T16:00:37.238Z"}, {"entity": "publication", "iuid": "72366a5fda114992bd1bbdfa17219211", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/72366a5fda114992bd1bbdfa17219211.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/72366a5fda114992bd1bbdfa17219211"}}, "title": "Hypercoagulation detected by Rotational Thromboelastometry predicts mortality in COVID-19: A risk model based on a prospective observational study.", "authors": [{"family": "Almskog", "given": "Lou M", "initials": "LM"}, {"family": "Wikman", "given": "Agneta", "initials": "A"}, {"family": "Svensson", "given": "Jonas", "initials": "J"}, {"family": "Bottai", "given": "Matteo", "initials": "M"}, {"family": "Kotorman", "given": "Mariann", "initials": "M"}, {"family": "Wahlgren", "given": "Carl Magnus", "initials": "CM"}, {"family": "Wanecek", "given": "Michael", "initials": "M"}, {"family": "van der Linden", "given": "Jan", "initials": "J"}, {"family": "Agren", "given": "Anna", "initials": "A"}], "type": "posted-content", "published": "2021-05-02", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.29.21256241", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-06T05:55:09.580Z", "modified": "2021-05-29T16:36:11.743Z"}, {"entity": "publication", "iuid": "63be2794a8004e448f9fdca621b953b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63be2794a8004e448f9fdca621b953b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63be2794a8004e448f9fdca621b953b0"}}, "title": "Aspirin and NSAID use and the risk of COVID-19", "authors": [{"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Guo", "given": "Chuan Guo", "initials": "CG"}, {"family": "Lee", "given": "Karla A", "initials": "KA"}, {"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Lo", "given": "Chun Han", "initials": "CH"}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Mehta", "given": "Raaj S", "initials": "RS"}, {"family": "Kwon", "given": "Sohee", "initials": "S"}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Song", "given": "Mingyang", "initials": "M"}, {"family": "Davies", "given": "Richard", "initials": "R"}, {"family": "Capdevila", "given": "Joan", "initials": "J"}, {"family": "Lochlainn", "given": "Mary Ni", "initials": "MN"}, {"family": "Sudre", "given": "Carole H", "initials": "CH", "orcid": "0000-0001-5753-428X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c26472813fed4007a8757af771de1802.json"}}, {"family": "Graham", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-4170-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f5f4e19812a46ed9e873732ec25e28d.json"}}, {"family": "Varsavsky", "given": "Thomas", "initials": "T"}, {"family": "Gomez", "given": "Maria F", "initials": "MF"}, {"family": "Kennedy", "given": "Beatrice", "initials": "B"}, {"family": "Fitipaldi", "given": "Hugo", "initials": "H"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Spector", "given": "Tim D", "initials": "TD"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S", "orcid": "0000-0002-5694-5340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74c7b9b1633144879042d198c7205656.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}], "type": "posted-content", "published": "2021-05-02", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.28.21256261", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "Health data research innovation gateway", "key": "https://healthdatagateway.org/detail/9b604483-9cdc-41b2-b82c-14ee3dd705f6", "description": "Anonymized data is available to be shared with bonafide researchers HDRUK according to their protocols"}, {"db": "ZOE covid study", "key": "https://covid.joinzoe.com", "description": "Data updates for covid study"}], "notes": [], "created": "2021-05-06T05:56:52.220Z", "modified": "2023-06-19T15:28:02.337Z"}, {"entity": "publication", "iuid": "070bbe0d37c84be0a2e31eeff5e35c3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/070bbe0d37c84be0a2e31eeff5e35c3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/070bbe0d37c84be0a2e31eeff5e35c3d"}}, "title": "Therapeutic plasma exchange (TPE) as a plausible rescue therapy in severe vaccine-induced immune thrombotic thrombocytopenia", "authors": [{"family": "Rock", "given": "Gail", "initials": "G"}, {"family": "Weber", "given": "Viktoria", "initials": "V"}, {"family": "Stegmayr", "given": "Bernd", "initials": "B"}], "type": "journal-article", "published": "2021-05-00", "journal": {"title": "Transfusion and Apheresis Science", "issn": "1473-0502", "issn-l": null, "volume": null, "issue": null, "pages": "103174"}, "abstract": null, "doi": "10.1016/j.transci.2021.103174", "pmid": null, "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-06-08T08:43:34.819Z", "modified": "2021-06-08T08:43:48.285Z"}, {"entity": "publication", "iuid": "44a461149ac34464b639e5263b01da57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44a461149ac34464b639e5263b01da57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44a461149ac34464b639e5263b01da57"}}, "title": "Stigma, Trust, and procedural integrity: Covid-19 testing in Malawi.", "authors": [{"family": "Ferree", "given": "Karen E", "initials": "KE"}, {"family": "Harris", "given": "Adam S", "initials": "AS"}, {"family": "Dulani", "given": "Boniface", "initials": "B"}, {"family": "Kao", "given": "Kristen", "initials": "K"}, {"family": "Lust", "given": "Ellen", "initials": "E"}, {"family": "Metheney", "given": "Erica", "initials": "E"}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "World Dev", "issn": "0305-750X", "volume": "141", "issue": null, "pages": "105351", "issn-l": null}, "abstract": "An emerging consensus in public health views testing for Covid-19 as key to managing the pandemic. It is often assumed that citizens have a strong desire to know their Covid-19 status, and will therefore take advantage of testing opportunities. This may not be the case in all contexts, however, especially those where citizens perceive stigma associated with the Covid-19, have low trust in health institutions, and doubt the procedural integrity of the testing process. This article explores willingness to receive a free Covid-19 test via a vignette experiment (conjoint design) embedded in a phone survey conducted in Malawi in May 2020. The experiment varied test provider (public clinic versus international health organization), proximity to illness, and reassurance of confidentiality. We find that Malawians expect higher uptake of testing in their community when the international health organization offered the test rather than a public clinic, an effect we attribute to higher trust in the organization and/or perceptions of greater capacity to ensure procedural integrity. The confidentiality reassurance did not substantially alter beliefs about the privacy of results, but did increase doubts about the willingness of community members to get tested in a public health clinic. Our findings suggest the importance of considering the demand side of testing in addition to well-known challenges of supply.", "doi": "10.1016/j.worlddev.2020.105351", "pmid": "33456104", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0305-750X(20)30479-4"}, {"db": "pmc", "key": "PMC7803152"}], "notes": [], "created": "2021-03-06T10:23:01.391Z", "modified": "2021-03-06T10:23:01.404Z"}, {"entity": "publication", "iuid": "275782e9e32446cea2ff723ecad7d2e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/275782e9e32446cea2ff723ecad7d2e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/275782e9e32446cea2ff723ecad7d2e2"}}, "title": "Role of the SphK-S1P-S1PRs pathway in invasion of the nervous system by SARS-CoV-2 infection.", "authors": [{"family": "Pan", "given": "Yuehai", "initials": "Y"}, {"family": "Gao", "given": "Fei", "initials": "F"}, {"family": "Zhao", "given": "Shuai", "initials": "S"}, {"family": "Han", "given": "Jinming", "initials": "J"}, {"family": "Chen", "given": "Fan", "initials": "F"}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Clin Exp Pharmacol Physiol", "issn": "0305-1870", "volume": "48", "issue": "5", "pages": "637-650", "issn-l": null}, "abstract": "Global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still ongoing. Before an effective vaccine is available, the development of potential treatments for resultant coronavirus disease 2019 (COVID-19) is crucial. One of the disease hallmarks is hyper-inflammatory responses, which usually leads to a severe lung disease. Patients with COVID-19 also frequently suffer from neurological symptoms such as acute diffuse encephalomyelitis, brain injury and psychiatric complications. The metabolic pathway of sphingosine-1-phosphate (S1P) is a dynamic regulator of various cell types and disease processes, including the nervous system. It has been demonstrated that S1P and its metabolic enzymes, regulating neuroinflammation and neurogenesis, exhibit important functions during viral infection. S1P receptor 1 (S1PR1) analogues including AAL-R and RP-002 inhibit pathophysiological responses at the early stage of H1N1 virus infection and then play a protective role. Fingolimod (FTY720) is an S1P receptor modulator and is being tested for treating COVID-19. Our review provides an overview of SARS-CoV-2 infection and critical role of the SphK-S1P-SIPR pathway in invasion of SARS-CoV-2 infection, particularly in the central nervous system (CNS). This may help design therapeutic strategies based on the S1P-mediated signal transduction, and the adjuvant therapeutic effects of S1P analogues to limit or prevent the interaction between the host and SARS-CoV-2, block the spread of the SARS-CoV-2, and consequently treat related complications in the CNS.", "doi": "10.1111/1440-1681.13483", "pmid": "33565127", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8014301"}], "notes": [], "created": "2021-02-10T18:59:44.359Z", "modified": "2021-07-14T07:52:09.600Z"}, {"entity": "publication", "iuid": "a5b6512797d7493d89230b70f9d0b4a3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a5b6512797d7493d89230b70f9d0b4a3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a5b6512797d7493d89230b70f9d0b4a3"}}, "title": "Residual antimicrobial agents in food originating from animals.", "authors": [{"family": "Hassan", "given": "Mohammad Mahmudul", "initials": "MM"}, {"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}, {"family": "Khan Nayem", "given": "Md Raihan", "initials": "MR"}, {"family": "Tanzin", "given": "Abu Zubayer", "initials": "AZ"}, {"family": "Badsha", "given": "Md Rahim", "initials": "MR"}, {"family": "Khan", "given": "Shahneaz Ali", "initials": "SA"}, {"family": "Ashour", "given": "Hossam M", "initials": "HM"}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Trends Food Sci Technol", "issn": "0924-2244", "volume": "111", "issue": null, "pages": "141-150", "issn-l": null}, "abstract": "The agricultural food products industry in Bangladesh depends on utilizing antimicrobials indiscriminately as growth promoters and for controlling infectious diseases. Thus, there is always a risk of antimicrobial agent accumulation in food sources that originate from agricultural production.\n\nIn the present study, we collected data from published articles between January, 2013 and December, 2019 on antimicrobial residues in human food sources such as meat, milk, eggs, and fishes.\n\nLiver contained the highest percentage of antimicrobial residues (74%; 95% CI: 59.66-85.37) against the invitro enteric pathogen Escherichia coli in layer chickens. Similar results were demonstrated in liver (68%; 95% CI: 53.30-80.48) and kidney (66%, 95% CI: 51.23-78.79) of layer chickens against Bacillus cereus and Bacillus subtilis. Amongst all antibiotics, the highest concentrations of ciprofloxacin were detected in kidney (48.57%; 95% CI: 31.38-66.01), followed by liver (47.56; 95% CI: 40.88-54.30) of broiler chickens. Ciprofloxacin was also present in liver (46.15%; 95% CI: 33.70-58.96) of layer chickens. The percentage of ciprofloxacin in thigh and breast meat in broiler bird were 41.54% (95% CI: 34.54-48.79) and 37.95% (95% CI: 31.11-45.15) respectively. Enrofloxacin was the second most dominant antimicrobial agent and was present in the liver of both types of poultry (Broiler and Layer chickens: 41.54%; 95% CI: 29.44-54.4 and 437.33%; 95% CI: 30.99-44.01). The prevalence rates of enrofloxacin in thigh and breast meat of broiler chickens were 24.10% (95% CI: 18.28-30.73) and 20.51% (95% CI: 15.08-26.87), respectively. Tetracycline, a commonly used antibiotic in livestock, was present in the liver (49.23%; 95% CI: 36.60-61.93) of layer chickens. In case of aquaculture food products, the highest amount of amoxicillin (683.2 mg/kg) was detected in Tilapia fish (Oreochromis niloticus), followed by 584.4 mg/kg in climbing perch (Anabas testudineus) and 555.6 mg/kg in Rui fish (Labeo rohita). Among the five types of fishes, Rui fish (0.000515 mg/kg) contained the highest concentrations of chloramphenicol antibiotic residues.\n\nThe presence of antimicrobial residues in meat, milk, egg, and fish is a serious public health threat due to the potential induction of antimicrobial resistance. It can negatively impact the food supply chain, especially with the current strain that it is already facing with the current COVID-19 pandemic. The findings of the present study highlight the ongoing risk of residual antimicrobial agents in food of animal origin in Bangladesh and countries with similar practices. This can draw the attention of public health officials to propose plans to mitigate or stop this practice.", "doi": "10.1016/j.tifs.2021.01.075", "pmid": "33746363", "labels": {"Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0924-2244(21)00083-2"}, {"db": "pmc", "key": "PMC7953985"}], "notes": [], "created": "2021-03-29T14:16:29.522Z", "modified": "2021-03-29T14:16:29.545Z"}, {"entity": "publication", "iuid": "a669fe2e8b544fad8541143ddb165f62", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a669fe2e8b544fad8541143ddb165f62.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a669fe2e8b544fad8541143ddb165f62"}}, "title": "Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of COVID-19 death.", "authors": [{"family": "Szekely", "given": "Laszlo", "initials": "L", "orcid": "0000-0001-6144-6573", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/906008558d5c4734bb28388154759186.json"}}, {"family": "Bozoky", "given": "Bela", "initials": "B"}, {"family": "Bendek", "given": "Matyas", "initials": "M"}, {"family": "Ostad", "given": "Masih", "initials": "M"}, {"family": "Lavignasse", "given": "Pablo", "initials": "P"}, {"family": "Haag", "given": "Lars", "initials": "L", "orcid": "0000-0002-9268-0562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fd8deb7580e4371901510e07ca478ab.json"}}, {"family": "Wu", "given": "Jieyu", "initials": "J", "orcid": "0000-0002-7063-6990", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3c151e3e7ed4d3f81fbfc398e7828ce.json"}}, {"family": "Jing", "given": "Xu", "initials": "X"}, {"family": "Gupta", "given": "Soham", "initials": "S"}, {"family": "Saccon", "given": "Elisa", "initials": "E", "orcid": "0000-0003-3283-4432", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/28cbb3510cbc4bf5b4db2bee1689467f.json"}}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Cao", "given": "Yihai", "initials": "Y"}, {"family": "Bj\u00f6rnstedt", "given": "Mikael", "initials": "M"}, {"family": "Szakos", "given": "Attila", "initials": "A"}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "issn-l": null, "volume": "7", "issue": "5", "pages": "e07134"}, "abstract": "Most COVID-19 victims are old and die from unrelated causes. Here we present twelve complete autopsies, including two rapid autopsies of young patients where the cause of death was COVID-19 ARDS. The main virus induced pathology was in the lung parenchyma and not in the airways. Most coagulation events occurred in the intra-alveolar and not in the intra-vascular space and the few thrombi were mainly composed of aggregated thrombocytes. The dominant inflammatory response was the massive accumulation of CD163 + macrophages and the disappearance of T killer, NK and B-cells. The virus was replicating in the pneumocytes and macrophages but not in bronchial epithelium, endothelium, pericytes or stromal cells. The lung consolidations were produced by a massive regenerative response, stromal and epithelial proliferation and neovascularization. We suggest that thrombocyte aggregation inhibition, angiogenesis inhibition and general proliferation inhibition may have a roll in the treatment of advanced COVID-19 ARDS.", "doi": "10.1016/j.heliyon.2021.e07134", "pmid": "34056141", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC8141733"}, {"db": "pii", "key": "S2405-8440(21)01237-8"}], "notes": [], "created": "2021-06-02T13:16:12.980Z", "modified": "2023-06-19T14:35:28.386Z"}, {"entity": "publication", "iuid": "86d82d91b8c742a4b1f99b3b3e91e1e3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86d82d91b8c742a4b1f99b3b3e91e1e3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86d82d91b8c742a4b1f99b3b3e91e1e3"}}, "title": "Nitric oxide and COVID\u201019: Dose, timing and how to administer it might be crucial", "authors": [{"family": "Frostell", "given": "Claes G", "initials": "CG", "orcid": "0000-0002-7199-1310", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874beab519f143db8659a7936aa46142.json"}}, {"family": "Hedenstierna", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0002-2923-6012", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cee3c79aa318422ba4bcfceeb5f5e44c.json"}}], "type": "journal-article", "published": "2021-05-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "0001-5172", "volume": "65", "issue": "5", "pages": "576-577", "issn-l": null}, "abstract": "Nitric oxide (NO) for inhalation has been a clinical option in the ICU since the early 1990s. Much has been written and claimed after the initial enthusiasm over an acutely improved arterial oxygenation in adult patients with ARDS. A few years ago, a meta-analysis (1) concluded that the regular use of inhaled NO (iNO) in patients with ARDS outside a clinical trial could not be recommended, as no benefit such as reduced mortality or time on the ventilator could be identified in published randomized studies.", "doi": "10.1111/aas.13788", "pmid": "33533477", "labels": {"Type: Other": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-04T18:11:58.380Z", "modified": "2021-06-18T11:22:27.514Z"}, {"entity": "publication", "iuid": "50767935110245d6b5ce53ca33f247c3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50767935110245d6b5ce53ca33f247c3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50767935110245d6b5ce53ca33f247c3"}}, "title": "Mortality trends among hospitalised COVID-19 patients in Sweden: A nationwide observational cohort study", "authors": [{"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-8801-3169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37509c3832244b019b91a1fe2cbe183e.json"}}, {"family": "Wahlstr\u00f6m", "given": "Erik", "initials": "E", "orcid": "0000-0002-0800-8520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f623177f84a4f4ba85571b106e4cec5.json"}}, {"family": "Walther", "given": "Sten", "initials": "S"}, {"family": "Bennet-Bark", "given": "Anna M", "initials": "AM"}, {"family": "Heurgren", "given": "Mona", "initials": "M"}, {"family": "Lind\u00e9n", "given": "Thomas", "initials": "T"}, {"family": "Holm", "given": "Johanna", "initials": "J", "orcid": "0000-0002-0220-3288", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33faae9af4924abdb8f29a6abf0d2f2a.json"}}, {"family": "Hanberger", "given": "H\u00e5kan", "initials": "H", "orcid": "0000-0002-4199-0229", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ccccceb630874fc5ab7507a313b59039.json"}}], "type": "journal-article", "published": "2021-05-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "4", "issue": null, "pages": "100054", "issn-l": null}, "abstract": "It is important to know if mortality among hospitalised COVID-19 patients has changed as the pandemic has progressed. The aim of this study was to describe the dynamics over time of mortality among patients hospitalised for COVID-19 in Sweden, using nationwide data compiled by the Swedish National Board of Health and Welfare.\n\nObservational cohort study where all patients hospitalised in Sweden between March 1 and September 30, 2020, with SARS-CoV-2 RNA positivity 14 days before to 5 days after admission and a discharge code for COVID-19 were included. Outcome was 60-day all-cause mortality. Patients were categorised according to month of hospital admission. Poisson regression was used to estimate the relative risk of death by month of admission, adjusting for, age, sex, comorbidities, care dependency, country of birth, healthcare region, and Simplified Acute Physiology, version 3 (patients in intensive care units; ICU).\n\nA total of 17,140 patients were included, of which 2943 died within 60 days of admission. The overall 60-day mortality was thus 17\u00b72% (95% CI, 16\u00b76%-17\u00b77%), and it decreased from 24\u00b77% (95% CI, 23\u00b70%-26\u00b75%) in March to 10\u00b74% (95% CI, 8\u00b79%-12\u00b71%) post-wave (July-September). Adjusted relative risk (RR) of death was 0\u00b746 (95% CI, 0\u00b739-0\u00b754) post-wave, using March as reference. Corresponding RR for patients not admitted to ICU and those admitted to ICU were 0\u00b749 (95% CI, 0\u00b742-0\u00b759) and 0\u00b749 (95% CI, 0\u00b733-0\u00b772), respectively. The proportion of patients admitted to ICU decreased from 19\u00b74% (95% CI, 17\u00b79%-21\u00b71%) in the March cohort to 8\u00b79% (95% CI, 7\u00b75%-10\u00b76%) post-wave.\n\nThere was a gradual decline in mortality during the spring of 2020 in Swedish hospitalised COVID-19 patients, independent of baseline patient characteristics. Future research is needed to explain the reasons for this decline. The changing COVID-19 mortality should be taken into account when management and results of studies from the first pandemic wave are evaluated.\n\nThis study was funded by Sweden's National Board of Health and Welfare.", "doi": "10.1016/j.lanepe.2021.100054", "pmid": "33997829", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00031-4"}, {"db": "pmc", "key": "PMC7907732"}], "notes": [], "created": "2021-05-21T17:00:23.534Z", "modified": "2022-11-21T15:34:05.650Z"}, {"entity": "publication", "iuid": "9b66926507624c89bdbb6a379fc5f0d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b66926507624c89bdbb6a379fc5f0d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b66926507624c89bdbb6a379fc5f0d5"}}, "title": "Lockdown Measures Which Reduced Greenhouse Gas Emissions With Little Negative Impact on Quality of Life.", "authors": [{"family": "Niemi", "given": "Maria", "initials": "M", "orcid": "0000-0001-5407-6981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/335195cc925f4f438775330e3a1f5a8e.json"}}, {"family": "Skelton", "given": "Alasdair", "initials": "A", "orcid": "0000-0002-3732-7993", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1be6eb7f00b14da890385f496318bf7a.json"}}, {"family": "Noone", "given": "Kevin", "initials": "K", "orcid": "0000-0001-7095-7412", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e045eacf18242a2a27a31f1b56738dd.json"}}, {"family": "Olsson", "given": "Mats J", "initials": "MJ", "orcid": "0000-0001-5592-3759", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cdd692617b7d475dba4532b2d28a8cc6.json"}}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Earths Future", "issn": "2328-4277", "volume": "9", "issue": "5", "pages": "e2020EF001909", "issn-l": null}, "abstract": "Lockdown measures in response to the new Covid-19 virus have caused the largest ever fall of annual greenhouse gas emissions. A key question that we attempt to answer in this study is which, if any, of these measures can be productively encouraged post-lockdown in efforts to sustain at least part of this reduction in emissions. Sweden is uniquely suited for our study because the voluntary nature of lockdown in Sweden allowed us to assess the level of compliance to recommendations and its effects on greenhouse gas emissions. First, we assessed the change of perceived quality of life (QOL) among 746 individuals from Stockholm region due to adhering to lockdown measures. Second, we calculated the associated change of annual per capita greenhouse emissions. We found that avoiding travel for work, avoiding purchasing, and avoiding restaurants had the least negative effect on QOL, and at the same time the largest positive effect on carbon dioxide equivalent (CO2e) emission reductions. We conclude that these are potential leverage points for stimulating behavioral change that has a positive climatic impact.", "doi": "10.1029/2020EF001909", "pmid": "34230885", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "EFT2794"}, {"db": "pmc", "key": "PMC8250258"}], "notes": [], "created": "2021-08-06T08:34:07.410Z", "modified": "2021-08-06T08:34:07.531Z"}, {"entity": "publication", "iuid": "1bd81d0ffef846729bedaa9804f6fdd1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1bd81d0ffef846729bedaa9804f6fdd1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1bd81d0ffef846729bedaa9804f6fdd1"}}, "title": "Higher vs Lower Doses of Dexamethasone in Patients with COVID\u201019 and Severe Hypoxia (COVID STEROID 2) trial: Protocol for a secondary Bayesian analysis", "authors": [{"family": "Granholm", "given": "Anders", "initials": "A", "orcid": "0000-0001-5799-7655", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d058ecb91d4c482abbee511b044ddf75.json"}}, {"family": "Munch", "given": "Marie Warrer", "initials": "MW", "orcid": "0000-0003-1127-9599", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dd56f64f991042da935f6f3836e087b0.json"}}, {"family": "Myatra", "given": "Sheila Nainan", "initials": "SN"}, {"family": "Vijayaraghavan", "given": "Bharath Kumar Tirupakuzhi", "initials": "BKT"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Wahlin", "given": "Rebecka Rubenson", "initials": "RR"}, {"family": "Jakob", "given": "Stephan M", "initials": "SM"}, {"family": "Cioccari", "given": "Luca", "initials": "L"}, {"family": "Kj\u00e6r", "given": "Maj\u2010Brit N\u00f8rregaard", "initials": "MN", "orcid": "0000-0002-6536-0504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/df8fa07399b448a5b689089e505dab58.json"}}, {"family": "Vesterlund", "given": "Gitte Kingo", "initials": "GK", "orcid": "0000-0001-5221-3938", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6eb5ff4bc5054887bfac267b8c8af411.json"}}, {"family": "Meyhoff", "given": "Tine Sylvest", "initials": "TS", "orcid": "0000-0002-1840-1596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/766fe5fd044944faabf6a96e8d6a72f0.json"}}, {"family": "Helleberg", "given": "Marie", "initials": "M"}, {"family": "M\u00f8ller", "given": "Morten Hylander", "initials": "MH", "orcid": "0000-0002-6378-9673", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b1cf88aaa5c9436a8e70ddfe39cfe4e8.json"}}, {"family": "Benfield", "given": "Thomas", "initials": "T"}, {"family": "Venkatesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Hammond", "given": "Naomi", "initials": "N"}, {"family": "Micallef", "given": "Sharon", "initials": "S"}, {"family": "Bassi", "given": "Abhinav", "initials": "A"}, {"family": "John", "given": "Oommen", "initials": "O"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Kristiansen", "given": "Klaus Tjelle", "initials": "KT"}, {"family": "Ulrik", "given": "Charlotte Suppli", "initials": "CS"}, {"family": "J\u00f8rgensen", "given": "Vibeke Lind", "initials": "VL"}, {"family": "Smitt", "given": "Margit", "initials": "M"}, {"family": "Bestle", "given": "Morten H", "initials": "MH"}, {"family": "Andreasen", "given": "Anne Sofie", "initials": "AS"}, {"family": "Poulsen", "given": "Lone Musaeus", "initials": "LM"}, {"family": "Rasmussen", "given": "Bodil Steen", "initials": "BS", "orcid": "0000-0003-2190-145X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa66146077394afea60f71d4be6daf06.json"}}, {"family": "Br\u00f8chner", "given": "Anne Craveiro", "initials": "AC"}, {"family": "Str\u00f8m", "given": "Thomas", "initials": "T"}, {"family": "M\u00f8ller", "given": "Anders", "initials": "A"}, {"family": "Khan", "given": "Mohd Saif", "initials": "MS"}, {"family": "Padmanaban", "given": "Ajay", "initials": "A"}, {"family": "Divatia", "given": "Jigeeshu Vasishtha", "initials": "JV"}, {"family": "Saseedharan", "given": "Sanjith", "initials": "S"}, {"family": "Borawake", "given": "Kapil", "initials": "K"}, {"family": "Kapadia", "given": "Farhad", "initials": "F"}, {"family": "Dixit", "given": "Subhal", "initials": "S"}, {"family": "Chawla", "given": "Rajesh", "initials": "R"}, {"family": "Shukla", "given": "Urvi", "initials": "U"}, {"family": "Amin", "given": "Pravin", "initials": "P"}, {"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Lange", "given": "Theis", "initials": "T"}, {"family": "Perner", "given": "Anders", "initials": "A", "orcid": "0000-0002-4668-0123", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f5d5120bc69c433f9df2b929d6be905a.json"}}], "type": "journal-article", "published": "2021-05-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "0001-5172", "volume": "65", "issue": "5", "pages": "702-710", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) can lead to severe hypoxic respiratory failure and death. Corticosteroids decrease mortality in severely or critically ill patients with COVID-19. However, the optimal dose remains unresolved. The ongoing randomised COVID STEROID 2 trial investigates the effects of higher vs. lower doses of dexamethasone (12 vs. 6 mg intravenously daily for up to 10 days) in 1,000 adult patients with COVID-19 and severe hypoxia.\n\nThis protocol outlines the rationale and statistical methods for a secondary, pre-planned Bayesian analysis of the primary outcome (days alive without life support at day 28) and all secondary outcomes registered up to day 90. We will use hurdle-negative binomial models to estimate the mean number of days alive without life support in each group and present results as mean differences and incidence rate ratios with 95% credibility intervals (CrIs). Additional count outcomes will be analysed similarly and binary outcomes will be analysed using logistic regression models with results presented as probabilities, relative risks and risk differences with 95% CrIs. We will present probabilities of any benefit/harm, clinically important benefit/harm and probabilities of effects smaller than pre-defined clinically minimally important differences for all outcomes analysed. Analyses will be adjusted for stratification variables and conducted using weakly informative priors supplemented by sensitivity analyses using sceptic priors.\n\nThis secondary, pre-planned Bayesian analysis will supplement the primary, conventional analysis and may help clinicians, researchers and policymakers interpret the results of the COVID STEROID 2 trial while avoiding arbitrarily dichotomised interpretations of the results.", "doi": "10.1111/aas.13793", "pmid": "33583027", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-15T07:51:08.706Z", "modified": "2021-06-18T12:05:18.966Z"}, {"entity": "publication", "iuid": "306ed55d95ef4f86be1ea42f3ed30577", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/306ed55d95ef4f86be1ea42f3ed30577.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/306ed55d95ef4f86be1ea42f3ed30577"}}, "title": "Disparities in European healthcare system approaches to maintaining continuity of medication for non-communicable diseases during the COVID-19 outbreak.", "authors": [{"family": "Kardas", "given": "Przemyslaw", "initials": "P"}, {"family": "van Boven", "given": "Job Frank Martien", "initials": "JFM"}, {"family": "Pinnock", "given": "Hilary", "initials": "H"}, {"family": "Menditto", "given": "Enrica", "initials": "E"}, {"family": "Wettermark", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Tsiligianni", "given": "Ioanna", "initials": "I"}, {"family": "\u00c1gh", "given": "Tam\u00e1s", "initials": "T"}, {"family": "ENABLE collaborators", "given": "", "initials": ""}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Lancet Reg Health Eur", "issn": "2666-7762", "volume": "4", "issue": null, "pages": "100099", "issn-l": null}, "abstract": null, "doi": "10.1016/j.lanepe.2021.100099", "pmid": "33875981", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-7762(21)00076-4"}, {"db": "pmc", "key": "PMC8046426"}], "notes": [], "created": "2021-04-23T04:43:57.860Z", "modified": "2021-04-23T04:43:57.883Z"}, {"entity": "publication", "iuid": "35781c4aec33447ba7f2cfc838ecbc55", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/35781c4aec33447ba7f2cfc838ecbc55.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/35781c4aec33447ba7f2cfc838ecbc55"}}, "title": "Blood group type A secretors are associated with a higher risk of COVID-19 cardiovascular disease complications.", "authors": [{"family": "Mankelow", "given": "Tosti J", "initials": "TJ", "orcid": "0000-0003-3434-1973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d109f82e8870460a82565faa2f7c47dd.json"}}, {"family": "Singleton", "given": "Belinda K", "initials": "BK"}, {"family": "Moura", "given": "Pedro L", "initials": "PL", "orcid": "0000-0002-0493-5394", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bf2544f4b3984c909d18106f49b9c9df.json"}}, {"family": "Stevens-Hernandez", "given": "Christian J", "initials": "CJ"}, {"family": "Cogan", "given": "Nicola M", "initials": "NM"}, {"family": "Gyorffy", "given": "Gyongyver", "initials": "G"}, {"family": "Kupzig", "given": "Sabine", "initials": "S"}, {"family": "Nichols", "given": "Luned", "initials": "L"}, {"family": "Asby", "given": "Claire", "initials": "C"}, {"family": "Pooley", "given": "Jennifer", "initials": "J"}, {"family": "Ruffino", "given": "Gabriella", "initials": "G"}, {"family": "Hosseini", "given": "Faroakh", "initials": "F"}, {"family": "Moghaddas", "given": "Fiona", "initials": "F"}, {"family": "Attwood", "given": "Marie", "initials": "M"}, {"family": "Noel", "given": "Alan", "initials": "A"}, {"family": "Cooper", "given": "Alex", "initials": "A"}, {"family": "Arnold", "given": "David T", "initials": "DT", "orcid": "0000-0003-3158-7740", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42abc73999ea4e25bed71b6538e00728.json"}}, {"family": "Hamilton", "given": "Fergus", "initials": "F", "orcid": "0000-0002-9760-4059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e862d4d0440241ecb9f9c985d638eb3d.json"}}, {"family": "Hyams", "given": "Catherine", "initials": "C", "orcid": "0000-0003-3923-1773", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e534f6c4f8c24e35b4e2df47282adfec.json"}}, {"family": "Finn", "given": "Adam", "initials": "A", "orcid": "0000-0003-1756-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cd0dbeb41b344aee99a7ace518c0938c.json"}}, {"family": "Toye", "given": "Ashley M", "initials": "AM", "orcid": "0000-0003-4395-9396", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/308984a5ffb44136892e9bc9d163e85d.json"}}, {"family": "Anstee", "given": "David J", "initials": "DJ", "orcid": "0000-0002-9066-1202", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2de3c70547b8454eb221ce5324686e0b.json"}}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "EJHaem", "issn": "2688-6146", "issn-l": null, "volume": "2", "issue": "2", "pages": "175-187"}, "abstract": "The SARS-CoV-2 virus causes COVID-19, an infection capable of causing severe disease and death but which can also be asymptomatic or oligosymptomatic. We investigated whether ABO blood group or secretor status was associated with COVID-19 severity. We investigated secretor status because expression of ABO glycans on secreted proteins and non-erythroid cells are controlled by a fucosyltransferase (FUT2), and inactivating FUT2 mutations result in a non-secretor phenotype which protects against some viral infections. Data combined from healthcare records and our own laboratory tests (n = 275) of hospitalized SARS-CoV-2 polymerase chain reaction positive patients confirmed higher than expected numbers of blood group A individuals compared to O (RR = 1.24, CI 95% [1.05, 1.47], p = 0.0111). There was also a significant association between group A and COVID-19-related cardiovascular complications (RR = 2.56, CI 95% [1.43, 4.55], p = 0.0011) which is independent of gender. Molecular analysis revealed that group A non-secretors are significantly less likely to be hospitalized than secretors. Testing of convalescent plasma donors, among whom the majority displayed COVID-19 symptoms and only a small minority required hospitalization, group A non-secretors were slightly over-represented. Our findings showed that group A non-secretors are not resistant to infection by SARS-CoV-2, but are more likely to experience a less severe form of associated disease.", "doi": "10.1002/jha2.180", "pmid": "34124710", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8176350"}, {"db": "pii", "key": "JHA2180"}], "notes": [], "created": "2021-06-17T07:42:38.844Z", "modified": "2023-06-19T07:44:36.576Z"}, {"entity": "publication", "iuid": "36cc2c82b9074d7480f9e6877b58a2e4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/36cc2c82b9074d7480f9e6877b58a2e4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/36cc2c82b9074d7480f9e6877b58a2e4"}}, "title": "A Method for Computerized Olfactory Assessment and Training Outside of Laboratory or Clinical Settings", "authors": [{"family": "Niedenthal", "given": "Simon", "initials": "S", "orcid": "0000-0003-4132-2287", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/afbb30dd20d446568597c1699a99e339.json"}}, {"family": "Nilsson", "given": "Johannes", "initials": "J"}, {"family": "Jerns\u00e4ther", "given": "Teodor", "initials": "T"}, {"family": "Cuartielles", "given": "David", "initials": "D"}, {"family": "Larsson", "given": "Maria", "initials": "M"}, {"family": "Olofsson", "given": "Jonas K", "initials": "JK", "orcid": "0000-0002-0856-0569", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5283494522f43cf8297e0226d08a665.json"}}], "type": "journal-article", "published": "2021-05-00", "journal": {"title": "i-Perception", "issn": "2041-6695", "volume": "12", "issue": "3", "pages": "204166952110239", "issn-l": null}, "abstract": null, "doi": "10.1177/20416695211023953", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:06:50.138Z", "modified": "2021-06-28T18:06:50.215Z"}, {"entity": "publication", "iuid": "a483737ffad34cd3a1ffd91e91ce8902", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a483737ffad34cd3a1ffd91e91ce8902.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a483737ffad34cd3a1ffd91e91ce8902"}}, "title": "The forgotten sub-regional COVID-19 response layer. The case of the WHO Eastern Mediterranean Region.", "authors": [{"family": "Ali Maher", "given": "Osama", "initials": "O"}, {"family": "Elamein Boshara", "given": "Mohamed Abdalla", "initials": "MA"}, {"family": "Pichierri", "given": "Giuseppe", "initials": "G"}, {"family": "Cegolon", "given": "Luca", "initials": "L"}, {"family": "Panu Napodano", "given": "Catello Mario", "initials": "CM"}, {"family": "Murgia", "given": "Paola", "initials": "P"}, {"family": "Bellizzi", "given": "Saverio", "initials": "S"}], "type": "journal article", "published": "2021-04-30", "journal": {"title": "J Infect Dev Ctries", "issn": "1972-2680", "volume": "15", "issue": "4", "pages": "478-479", "issn-l": null}, "abstract": "The response to the COVID-19 pandemic have been driven by epidemiology, health system characteristics and control measures in form of social/physical distancing. Guidance, information and best practices have been characterized by territorial thinking with concentration on national health system and social contexts. Information was to a large extent provided from global entities such as the World Health Organization (WHO), Centers for Disease Control and Prevention (CDC) and others. This bipolar response mechanism came to the detriment of regional and sub-regional levels. The development of the global pandemic was evaluated in terms of the performance of single countries without trying to reflect on possible regional or sub-regional results of similar characteristics in health system and social contexts. To have a clearer view of the issue of sub-regional similarities, we examined the WHO, Eastern Mediterranean Region. When examining the development of confirmed cases for countries in the region, we identified four different sub-groups similar in the development of the pandemic and the social distancing measure implemented. Despite the complicated situation, these groups gave space for thinking outside the box of traditional outbreaks or pandemic response. We think that this sub-regional approach could be very effective in addressing more characteristics and not geographically based analysis. Furthermore, this can be an area of additional conceptual approaches, modelling and concrete platforms for information and lessons learned exchange.", "doi": "10.3855/jidc.14057", "pmid": "33956646", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-17T19:05:28.720Z", "modified": "2021-05-17T19:05:28.744Z"}, {"entity": "publication", "iuid": "f8e8baec2aa84a5997263cd6b8c5edf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f8e8baec2aa84a5997263cd6b8c5edf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f8e8baec2aa84a5997263cd6b8c5edf3"}}, "title": "Fear of COVID-19 and workplace phobia among Pakistani doctors: A survey study.", "authors": [{"family": "Malik", "given": "Sadia", "initials": "S"}, {"family": "Ullah", "given": "Irfan", "initials": "I"}, {"family": "Irfan", "given": "Muhammad", "initials": "M"}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Rehman", "given": "Ibad Ur", "initials": "IU"}, {"family": "Minhas", "given": "Rafia", "initials": "R"}], "type": "journal article", "published": "2021-04-30", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "833"}, "abstract": "The novel coronavirus disease-2019 (COVID-19) has seriously affected the lives of millions of people across the world. It has also heavily burdened healthcare professionals and the virus poses serious risks for their personal and professional lives. Therefore, the present study examined the associations between fear of COVID-19 and workplace phobia among doctors in Pakistan during the COVID-19 pandemic.\r\n\r\nAn online survey was conducted among 421 doctors in Pakistan between April 10 and May 25, 2020. The Workplace Phobia Scale (WPS) and the Fear of COVID-19 Scale (FCV-19S) were the main psychometric instruments used in this study.\r\n\r\nThere was a significant positive relationship between fear of COVID-19 and workplace panic anxiety and workplace avoidance behavior. Significantly higher fear of COVID-19 was found among (i) females compared to males, (ii) doctors with 5 years or less of work experience compared to those with more than 5 years, and (iii) postgraduate trainees compared with other ranks. Two groups (doctors who were above 30 years old and postgraduate trainees) were found to have higher levels of workplace phobia compared to their counterparts. Doctors with severe levels of fear of COVID-19 had significantly higher levels of workplace panic anxiety and workplace avoidance behavior.\r\n\r\nFear of COVID-19 was significantly associated with workplace phobia which may negatively affect doctors' performance. Therefore, important steps are needed to protect doctors' health by providing sufficient resources to allay their fears and anxieties which consequently help them in carrying out their frontline duties in response to the COVID-19 pandemic.", "doi": "10.1186/s12889-021-10873-y", "pmid": "33931040", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-10873-y"}], "notes": [], "created": "2021-05-04T16:03:00.628Z", "modified": "2021-07-14T08:11:34.471Z"}, {"entity": "publication", "iuid": "0145b07c31204a1dabd9c607a0b1dccb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0145b07c31204a1dabd9c607a0b1dccb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0145b07c31204a1dabd9c607a0b1dccb"}}, "title": "A SARS-CoV-2 (COVID-19) biological network to find targets for drug repurposing.", "authors": [{"family": "Habibi", "given": "Mahnaz", "initials": "M"}, {"family": "Taheri", "given": "Golnaz", "initials": "G"}, {"family": "Aghdam", "given": "Rosa", "initials": "R"}], "type": "journal article", "published": "2021-04-30", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "9378", "issn-l": "2045-2322"}, "abstract": "The Coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus needs a fast recognition of effective drugs to save lives. In the COVID-19 situation, finding targets for drug repurposing can be an effective way to present new fast treatments. We have designed a two-step solution to address this approach. In the first step, we identify essential proteins from virus targets or their associated modules in human cells as possible drug target candidates. For this purpose, we apply two different algorithms to detect some candidate sets of proteins with a minimum size that drive a significant disruption in the COVID-19 related biological networks. We evaluate the resulted candidate proteins sets with three groups of drugs namely Covid-Drug, Clinical-Drug, and All-Drug. The obtained candidate proteins sets approve 16 drugs out of 18 in the Covid-Drug, 273 drugs out of 328 in the Clinical-Drug, and a large number of drugs in the All-Drug. In the second step, we study COVID-19 associated proteins sets and recognize proteins that are essential to disease pathology. This analysis is performed using DAVID to show and compare essential proteins that are contributed between the COVID-19 comorbidities. Our results for shared proteins show significant enrichment for cardiovascular-related, hypertension, diabetes type 2, kidney-related and lung-related diseases.", "doi": "10.1038/s41598-021-88427-w", "pmid": "33931664", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-88427-w"}, {"db": "github", "key": "(https://github.com/rosaaghdam/ Drug-Target", "description": "Datasets and the codes of the algorithms are available at the github repository"}], "notes": [], "created": "2021-05-04T16:02:32.234Z", "modified": "2021-11-18T10:16:36.362Z"}, {"entity": "publication", "iuid": "6c3d627eeb444987aba0fa10a8899671", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c3d627eeb444987aba0fa10a8899671.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c3d627eeb444987aba0fa10a8899671"}}, "title": "Prostate cancer diagnosis, staging, and treatment in Sweden during the first phase of the COVID-19 pandemic.", "authors": [{"family": "Fallara", "given": "Giuseppe", "initials": "G"}, {"family": "Sandin", "given": "Fredrik", "initials": "F"}, {"family": "Styrke", "given": "Johan", "initials": "J"}, {"family": "Carlsson", "given": "Stefan", "initials": "S"}, {"family": "Lissbrant", "given": "Ingela Franck", "initials": "IF"}, {"family": "Ahlgren", "given": "Johan", "initials": "J"}, {"family": "Bratt", "given": "Ola", "initials": "O"}, {"family": "Lambe", "given": "Mats", "initials": "M"}, {"family": "Stattin", "given": "P\u00e4r", "initials": "P"}], "type": "journal article", "published": "2021-04-29", "journal": {"title": "Scand J Urol", "issn": "2168-1813", "issn-l": null, "volume": null, "issue": null, "pages": "1-8"}, "abstract": "The first case of COVID-19 in Sweden was diagnosed in late January 2020, the first recommendations against the spread of the virus were released in mid-March, and the peak of the first wave of the pandemic was reached in March-June. The aim of this cross-sectional study was to assess the short-term effects of the first wave of the COVID-19 pandemic on prostate cancer (PCa) diagnosis, staging, and treatment.\r\n\r\nData in the National Prostate Cancer Register (NPCR) of Sweden on newly diagnosed PCa cases and on the number of diagnostic and therapeutic procedures performed between 18 March 2020 and 2 June 2020 were compared with those in the corresponding time periods in 2017-2019, as reported until January 31 of the year after each study period.\r\n\r\nDuring the study period in 2020, 36% fewer PCa cases were registered in NPCR compared with the corresponding time period in previous years: 1458 cases in 2020 vs a mean of 2285 cases in 2017-2019. The decrease in new PCa registrations was more pronounced in men above age 75 years, down 51%, than in men aged 70-75, down 37%, and in men below age 70, down 28%. There was no decrease in the number of radical prostatectomies and number of radical radiotherapy courses increased by 32%.\r\n\r\nDuring the peak of the first phase of the COVID-19 pandemic, the number of men diagnosed with PCa in Sweden decreased by one third compared with previous years, whereas there was no decrease in the number of curative treatments.", "doi": "10.1080/21681805.2021.1910341", "pmid": "33913376", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-30T04:14:25.081Z", "modified": "2021-08-25T14:32:40.013Z"}, {"entity": "publication", "iuid": "a2a8bc6a039241c1a9cbd3f58591f371", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2a8bc6a039241c1a9cbd3f58591f371.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2a8bc6a039241c1a9cbd3f58591f371"}}, "title": "OxCOVID19 Database, a multimodal data repository for better understanding the global impact of COVID-19", "authors": [{"family": "Mahdi", "given": "Adam", "initials": "A"}, {"family": "B\u0142aszczyk", "given": "Piotr", "initials": "P"}, {"family": "D\u0142otko", "given": "Pawe\u0142", "initials": "P"}, {"family": "Salvi", "given": "Dario", "initials": "D"}, {"family": "Chan", "given": "Tak Shing", "initials": "TS"}, {"family": "Harvey", "given": "John", "initials": "J"}, {"family": "Gurnari", "given": "Davide", "initials": "D"}, {"family": "Wu", "given": "Yue", "initials": "Y"}, {"family": "Farhat", "given": "Ahmad", "initials": "A"}, {"family": "Hellmer", "given": "Niklas", "initials": "N"}, {"family": "Zarebski", "given": "Alexander", "initials": "A"}, {"family": "Hogan", "given": "Bernie", "initials": "B"}, {"family": "Tarassenko", "given": "Lionel", "initials": "L"}], "type": "journal-article", "published": "2021-04-29", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": null}, "abstract": null, "doi": "10.1038/s41598-021-88481-4", "pmid": "33927237", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://github.com/covid19db/data", "description": "Code for data acquisition and cleaning used in the processing of assembling the OxCOVID19 Database"}, {"db": "URL", "key": "https://doi.org/10.6084/m9.figshare.12746150", "description": "Static data (snapshot described in the manuscript) with a DOI"}, {"db": "URL", "key": "https://github.com/covid19db/data/tree/master/data-epidemiology", "description": "Latest data, epidemiology: number of confirmed cases and deaths for different countries, etc."}, {"db": "URL", "key": "https://github.com/covid19db/data/tree/master/data-government-response", "description": "Latest data, government response: data on government response to COVID-19"}, {"db": "URL", "key": "https://github.com/covid19db/data/tree/master/data-mobility", "description": "Latest data, mobility: human mobility collected by mobile phones"}], "notes": [], "created": "2021-05-04T16:11:05.623Z", "modified": "2021-06-21T14:57:10.184Z"}, {"entity": "publication", "iuid": "37a0f26523b8445a96c1a38b8538bf9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/37a0f26523b8445a96c1a38b8538bf9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/37a0f26523b8445a96c1a38b8538bf9c"}}, "title": "Irrational pharmacy practice and inadequate health care services in Bangladesh: a lesson learned from COVID-19 pandemic.", "authors": [{"family": "Jakaria", "given": "Md", "initials": "M"}, {"family": "Azam", "given": "Shofiul", "initials": "S"}, {"family": "Siddiqui", "given": "Shafayet Ahmed", "initials": "SA"}, {"family": "Hoq", "given": "Mohammad Injamul", "initials": "MI"}, {"family": "Islam", "given": "Mohammad Safiqul", "initials": "MS"}], "type": "editorial", "published": "2021-04-29", "journal": {"title": "J Basic Clin Physiol Pharmacol", "issn": "2191-0286", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1515/jbcpp-2020-0505", "pmid": "33915611", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "jbcpp-2020-0505"}], "notes": [], "created": "2021-05-04T16:29:12.566Z", "modified": "2021-05-04T16:29:28.541Z"}, {"entity": "publication", "iuid": "b3c273a0542e4e4db386a5c04855600f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b3c273a0542e4e4db386a5c04855600f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b3c273a0542e4e4db386a5c04855600f"}}, "title": "Endothelin Antagonism and Sodium Glucose Co-transporter 2 Inhibition A Potential Combination Therapeutic Strategy for COVID-19.", "authors": [{"family": "Fisk", "given": "Marie", "initials": "M"}, {"family": "Althage", "given": "Magnus", "initials": "M"}, {"family": "Moosmang", "given": "Sven", "initials": "S"}, {"family": "Greasley", "given": "Peter J", "initials": "PJ"}, {"family": "Cope", "given": "Andrew P", "initials": "AP"}, {"family": "Jayne", "given": "David Rw", "initials": "DR"}, {"family": "Galloway", "given": "James", "initials": "J"}, {"family": "Hall", "given": "Frances", "initials": "F"}, {"family": "Wilkinson", "given": "Ian B", "initials": "IB"}, {"family": "Ambery", "given": "Philip", "initials": "P"}, {"family": "Cheriyan", "given": "Joseph", "initials": "J"}], "type": "journal article", "published": "2021-04-29", "journal": {"title": "Pulm Pharmacol Ther", "issn": "1522-9629", "volume": null, "issue": null, "pages": "102035", "issn-l": null}, "abstract": "The novel coronavirus 2019 (COVID-19) infection caused by SARS-CoV-2 is a global pandemic that requires a multi-faceted approach to tackle this unprecedent health crisis. Therapeutics to treat COVID-19 are an integral part of any such management strategy and there is a substantial unmet need for treatments for individuals most at risk of severe disease. This perspective review provides rationale of a combined therapeutic regimen of selective endothelin-A (ET-A) receptor antagonism and sodium glucose co-transporter-2 (SGLT-2) inhibition to treat COVID-19. Endothelin is a potent vasoconstrictor with pro-inflammatory and atherosclerotic effects. It is upregulated in a number of conditions including acute respiratory distress syndrome and cardiovascular disease. Endothelin mediates vasocontractility via endothelin (ET-A and ET-B) receptors on vascular smooth muscle cells (VSMCs). ET-B receptors regulate endothelin clearance and are present on endothelial cells, where in contrast to their role on VSMCs, mediate vasodilation. Therefore, selective endothelin-A (ET-A) receptor inhibition is likely the optimal approach to attenuate the injurious effects of endothelin and may reduce ventilation-perfusion mismatch and pulmonary inflammation, whilst improving pulmonary haemodynamics and oxygenation. SGLT-2 inhibition may dampen inflammatory cytokines, reduce hyperglycaemia if present, improve endothelial function, cardiovascular haemodynamics and cellular bioenergetics. This combination therapeutic approach may therefore have beneficial effects to mitigate both the pulmonary, metabolic and cardiorenal manifestations of COVID-19. Given these drug classes include medicines licensed to treat heart failure, diabetes and pulmonary hypertension respectively, information regarding their safety profile is established. Randomised controlled clinical trials are the best way to determine efficacy and safety of these medicines in COVID-19.", "doi": "10.1016/j.pupt.2021.102035", "pmid": "33933611", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1094-5539(21)00047-X"}], "notes": [], "created": "2021-05-04T16:01:42.634Z", "modified": "2021-05-04T16:02:01.268Z"}, {"entity": "publication", "iuid": "61a3cad77c90462490c5d783f81558d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61a3cad77c90462490c5d783f81558d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61a3cad77c90462490c5d783f81558d9"}}, "title": "Association of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes", "authors": [{"family": "Norman", "given": "Mikael", "initials": "M"}, {"family": "Nav\u00e9r", "given": "Lars", "initials": "L"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Ahlberg", "given": "Mia", "initials": "M"}, {"family": "Hervius Askling", "given": "Helena", "initials": "H"}, {"family": "Aronsson", "given": "Bernice", "initials": "B"}, {"family": "Bystr\u00f6m", "given": "Emma", "initials": "E"}, {"family": "Jonsson", "given": "Jerker", "initials": "J"}, {"family": "Sengpiel", "given": "Verena", "initials": "V"}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}, {"family": "H\u00e5kansson", "given": "Stellan", "initials": "S"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}], "type": "journal-article", "published": "2021-04-29", "journal": {"title": "JAMA", "issn": "0098-7484", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The outcomes of newborn infants of women testing positive for SARS-CoV-2 in pregnancy is unclear.\n\nTo evaluate neonatal outcomes in relation to maternal SARS-CoV-2 test positivity in pregnancy.\n\nNationwide, prospective cohort study based on linkage of the Swedish Pregnancy Register, the Neonatal Quality Register, and the Register for Communicable Diseases. Ninety-two percent of all live births in Sweden between March 11, 2020, and January 31, 2021, were investigated for neonatal outcomes by March 8, 2021. Infants with malformations were excluded. Infants of women who tested positive for SARS-CoV-2 were matched, directly and using propensity scores, on maternal characteristics with up to 4 comparator infants.\n\nMaternal test positivity for SARS-CoV-2 in pregnancy.\n\nIn-hospital mortality; neonatal resuscitation; admission for neonatal care; respiratory, circulatory, neurologic, infectious, gastrointestinal, metabolic, and hematologic disorders and their treatments; length of hospital stay; breastfeeding; and infant test positivity for SARS-CoV-2.\n\nOf 88 159 infants (49.0% girls), 2323 (1.6%) were delivered by mothers who tested positive for SARS-CoV-2. The mean gestational age of infants of SARS-CoV-2-positive mothers was 39.2 (SD, 2.2) weeks vs 39.6 (SD, 1.8) weeks for comparator infants, and the proportions of preterm infants (gestational age <37 weeks) were 205/2323 (8.8%) among infants of SARS-CoV-2-positive mothers and 4719/85 836 (5.5%) among comparator infants. After matching on maternal characteristics, maternal SARS-CoV-2 test positivity was significantly associated with admission for neonatal care (11.7% vs 8.4%; odds ratio [OR], 1.47; 95% CI, 1.26-1.70) and with neonatal morbidities such as respiratory distress syndrome (1.2% vs 0.5%; OR, 2.40; 95% CI, 1.50-3.84), any neonatal respiratory disorder (2.8% vs 2.0%; OR, 1.42; 95% CI, 1.07-1.90), and hyperbilirubinemia (3.6% vs 2.5%; OR, 1.47; 95% CI, 1.13-1.90). Mortality (0.30% vs 0.12%; OR, 2.55; 95% CI, 0.99-6.57), breastfeeding rates at discharge (94.4% vs 95.1%; OR, 0.84; 95% CI, 0.67-1.05), and length of stay in neonatal care (median, 6 days in both groups; difference, 0 days; 95% CI, -2 to 7 days) did not differ significantly between the groups. Twenty-one infants (0.90%) of SARS-CoV-2-positive mothers tested positive for SARS-CoV-2 in the neonatal period; 12 did not have neonatal morbidity, 9 had diagnoses with unclear relation to SARS-CoV-2, and none had congenital pneumonia.\n\nIn a nationwide cohort of infants in Sweden, maternal SARS-CoV-2 infection in pregnancy was significantly associated with small increases in some neonatal morbidities. Given the small numbers of events for many of the outcomes and the large number of statistical comparisons, the findings should be interpreted as exploratory.", "doi": "10.1001/jama.2021.5775", "pmid": "33914014", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-29T16:47:53.604Z", "modified": "2021-04-30T04:16:25.471Z"}, {"entity": "publication", "iuid": "f5e42570b7434d6ab37a5f6d964a3fdf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f5e42570b7434d6ab37a5f6d964a3fdf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f5e42570b7434d6ab37a5f6d964a3fdf"}}, "title": "The association between high risk of sleep apnea, comorbidities, and risk of COVID-19: a population-based international harmonized study", "authors": [{"family": "Chung", "given": "Frances", "initials": "F"}, {"family": "Waseem", "given": "Rida", "initials": "R"}, {"family": "Pham", "given": "Chi", "initials": "C"}, {"family": "Penzel", "given": "Thomas", "initials": "T"}, {"family": "Han", "given": "Fang", "initials": "F"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Espie", "given": "Colin A", "initials": "CA"}, {"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J"}, {"family": "Saaresranta", "given": "Tarja", "initials": "T"}, {"family": "Wing", "given": "Yun Kwok", "initials": "YK"}, {"family": "Nadorff", "given": "Michael R", "initials": "MR"}, {"family": "Dauvilliers", "given": "Yves", "initials": "Y"}, {"family": "De Gennaro", "given": "Luigi", "initials": "L"}, {"family": "Plazzi", "given": "Guiseppe", "initials": "G"}, {"family": "Merikanto", "given": "Ilona", "initials": "I"}, {"family": "Matsui", "given": "Kentaro", "initials": "K"}, {"family": "Leger", "given": "Damien", "initials": "D"}, {"family": "Sieminski", "given": "Mariusz", "initials": "M"}, {"family": "Mota-Rolim", "given": "Sergio", "initials": "S"}, {"family": "Inoue", "given": "Yuichi", "initials": "Y"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "International COVID Sleep Study (ICOSS) group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-04-28", "journal": {"title": "Sleep Breath", "issn": "1522-1709", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Obstructive sleep apnea (OSA) may increase the risk of severe COVID-19; however, the level of potential modulation has not yet been established. The objective of the study was to determine the association between high risk of OSA, comorbidities, and increased risk for COVID-19, hospitalization, and intensive care unit (ICU) treatment.\r\n\r\nWe conducted a cross-sectional population-based web survey in adults in 14 countries/regions. The survey included sociodemographic variables and comorbidities. Participants were asked questions about COVID-19, hospitalization, and ICU treatment. Standardized questionnaire (STOP questionnaire for high risk of OSA) was included. Multivariable logistic regression was conducted adjusting for various factors.\r\n\r\nOut of 26,539 respondents, 20,598 (35.4% male) completed the survey. Mean age and BMI of participants were 41.5 \u00b1 16.0 years and 24.0 \u00b1 5.0 kg/m 2, respectively. The prevalence of physician-diagnosed OSA was 4.1% and high risk of OSA was 9.5%. We found that high risk of OSA (adjusted odds ratio (aOR) 1.72, 95% confidence interval (CI): 1.20, 2.47) and diabetes (aOR 2.07, 95% CI: 1.23, 3.48) were associated with reporting of a COVID-19 diagnosis. High risk for OSA (aOR 2.11, 95% CI: 1.10-4.01), being male (aOR: 2.82, 95% CI: 1.55-5.12), having diabetes (aOR: 3.93, 95% CI: 1.70-9.12), and having depression (aOR: 2.33, 95% CI: 1.15-4.77) were associated with increased risk of hospitalization or ICU treatment.\r\n\r\nParticipants at high risk of OSA had increased odds of having COVID-19 and were two times more likely to be hospitalized or treated in ICU.", "doi": "10.1007/s11325-021-02373-5", "pmid": "33907966", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11325-021-02373-5"}], "notes": [], "created": "2021-04-29T09:42:48.077Z", "modified": "2021-07-14T08:09:42.536Z"}, {"entity": "publication", "iuid": "4bfc7bf6f16c4fa9b82e7973184438e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4bfc7bf6f16c4fa9b82e7973184438e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4bfc7bf6f16c4fa9b82e7973184438e2"}}, "title": "SVEPM 2020 - Resilience and community support in the first year of the COVID-19 pandemic: The Society for Veterinary Epidemiology and Preventive Medicine Annual Conference, extraordinarily held online.", "authors": [{"family": "D\u00f3rea", "given": "Fernanda C", "initials": "FC"}, {"family": "Vergne", "given": "Timoth\u00e9e", "initials": "T"}, {"family": "Brennan", "given": "Marnie", "initials": "M"}, {"family": "van Schaik", "given": "Gerdien", "initials": "G"}, {"family": "Barrett", "given": "Damien", "initials": "D"}, {"family": "Carmo", "given": "Lu\u00eds Pedro", "initials": "LP"}, {"family": "Robinson", "given": "Philip A", "initials": "PA"}, {"family": "Brodbelt", "given": "Dave C", "initials": "DC"}, {"family": "McIntyre", "given": "K Marie", "initials": "KM"}], "type": "editorial", "published": "2021-04-28", "journal": {"title": "Prev Vet Med", "issn": "1873-1716", "volume": "191", "issue": null, "pages": "105368", "issn-l": null}, "abstract": null, "doi": "10.1016/j.prevetmed.2021.105368", "pmid": "33933917", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0167-5877(21)00112-4"}], "notes": [], "created": "2021-05-04T16:01:16.608Z", "modified": "2021-05-04T16:01:16.631Z"}, {"entity": "publication", "iuid": "26e5d7282b7a402c9c5a0c78f0b36244", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26e5d7282b7a402c9c5a0c78f0b36244.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26e5d7282b7a402c9c5a0c78f0b36244"}}, "title": "Occupational burnout and job satisfaction among physicians in times of COVID-19 crisis: a convergent parallel mixed-method study.", "authors": [{"family": "Alrawashdeh", "given": "Hamzeh Mohammad", "initials": "HM"}, {"family": "Al-Tammemi", "given": "Ala'a B", "initials": "AB"}, {"family": "Alzawahreh", "given": "Mohammad Kh", "initials": "MK"}, {"family": "Al-Tamimi", "given": "Ashraf", "initials": "A"}, {"family": "Elkholy", "given": "Mohamed", "initials": "M"}, {"family": "Al Sarireh", "given": "Fawaz", "initials": "F"}, {"family": "Abusamak", "given": "Mohammad", "initials": "M"}, {"family": "Elehamer", "given": "Nafisa M K", "initials": "NMK"}, {"family": "Malkawi", "given": "Ahmad", "initials": "A"}, {"family": "Al-Dolat", "given": "Wedad", "initials": "W"}, {"family": "Abu-Ismail", "given": "Luai", "initials": "L"}, {"family": "Al-Far", "given": "Ali", "initials": "A"}, {"family": "Ghoul", "given": "Imene", "initials": "I"}], "type": "journal article", "published": "2021-04-28", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "811"}, "abstract": "Healthcare professionals including physicians were subjected to an increased workload during the COVID-19 crisis, leaving them exposed to significant physical and psychological distress. Therefore, our present study aimed to (i) assess the prevalence of burnout and levels of job satisfaction among physicians in Jordan, and (ii) explore physicians' opinions, experiences, and perceptions during the pandemic crisis.\r\n\r\nThis was a mixed-method study that utilized a structured web-based questionnaire and semi-structured individual interviews. The 10-Item Burnout Measure-Short version (BMS), and the 5-Item Short Index of Job Satisfaction (SIJS) were adopted to assess occupational burnout and job satisfaction, respectively. Semi-structured interviews were conducted, based on a conceptual framework that was developed from Herzberg's Two-Factor Theory of Motivation and Job Demands-Resources Model. Descriptive statistics and regression models, as well as inductive thematic analysis, were used to analyze quantitative and qualitative data, respectively.\r\n\r\nA total of 973 survey responses and 11 interviews were included in our analysis. The prevalence of burnout among physicians was (57.7%). Several significant factors were positively associated with burnout, including female gender, working at highly loaded hospitals, working for long hours, doing night shifts, lack of sufficient access to personal protective equipment, and being positively tested for SARS-CoV-2. Regarding job satisfaction, regression analysis revealed that age was positively associated with higher levels of job satisfaction. On contrary, being a general practitioner or specialist, working at highly loaded hospitals, low salaries, and suffering from burnout have predicted lower levels of job satisfaction. Besides, four themes have emerged from the thematic analysis: (i) Work-induced psychological distress during the pandemic, (ii) Decision-driven satisfactory and dissatisfactory experiences, (iii) Impact of the pandemic on doctor-patient communication and professional skills, and (iv) Economic impacts of the pandemic crisis and lockdown.\r\n\r\nA significant physical and psychological burden was associated with the COVID-19 pandemic. Reliable efforts should be implemented aiming at protecting physicians' physical and mental wellbeing, enhancing their working conditions, and raising awareness about burnout. Evidence-based decisions and proper utilization of financial and human resources at institutional and national levels are believed to be crucial for the sustainability of the health workforce, especially in crises.", "doi": "10.1186/s12889-021-10897-4", "pmid": "33906619", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-10897-4"}, {"db": "URL", "key": "https://doi.org/10.6084/m9.figshare.14058185.v1", "description": "Raw dataset: individual-level demographic, occupational, COVID-19, burnout, etc. data"}], "notes": [], "created": "2021-04-29T09:51:29.677Z", "modified": "2021-07-14T08:10:43.856Z"}, {"entity": "publication", "iuid": "0d490bda6d954f7d80ad15406ed1d900", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d490bda6d954f7d80ad15406ed1d900.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d490bda6d954f7d80ad15406ed1d900"}}, "title": "Organotypic human ex vivo models for coronavirus disease 2019 research and drug development.", "authors": [{"family": "Youhanna", "given": "Sonia", "initials": "S"}, {"family": "Wright", "given": "Shane C", "initials": "SC"}, {"family": "Lauschke", "given": "Volker M", "initials": "VM"}], "type": "journal article", "published": "2021-04-27", "journal": {"title": "Curr Opin Pharmacol", "issn": "1471-4973", "volume": "59", "issue": null, "pages": "11-18", "issn-l": null}, "abstract": "Since the discovery of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019, intense research efforts on an unprecedented scale have focused on the study of viral entry mechanisms and adaptive immunity. While the identification of angiotensin-converting enzyme 2 (ACE2) and other co-receptors has elucidated the molecular and structural basis for viral entry, the pathobiological mechanisms of SARS-CoV-2 in human tissues are less understood. Recent advances in bioengineering have opened opportunities for the use of organotypic human tissue models to investigate host-virus interactions and test antiviral drug candidates in a physiological context. Although it is too early to accurately quantify the added value of these systems compared with conventional cell systems, it can be assumed that these advanced three-dimensional (3D) models contribute toward improved result translation. This mini-review summarizes recent work to study SARS-CoV-2 infection in human 3D tissue models with an emphasis on the pharmacological tools that have been developed to understand and prevent viral entry and replication.", "doi": "10.1016/j.coph.2021.04.006", "pmid": "34029832", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1471-4892(21)00050-3"}, {"db": "pmc", "key": "PMC8075816"}], "notes": [], "created": "2021-05-29T15:42:16.272Z", "modified": "2021-05-29T15:42:16.294Z"}, {"entity": "publication", "iuid": "ecfb81283b8d4464a1a186821f9831ab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ecfb81283b8d4464a1a186821f9831ab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ecfb81283b8d4464a1a186821f9831ab"}}, "title": "Mathematical modeling suggests pre-existing immunity to SARS-CoV-2", "authors": [{"family": "Carlsson", "given": "Marcus", "initials": "M"}, {"family": "Hatem", "given": "Gad", "initials": "G"}, {"family": "Soderberg-Naucler", "given": "Cecilia", "initials": "C"}], "type": "posted-content", "published": "2021-04-27", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.21.21255782", "pmid": null, "labels": {"Type: Preprint": null, "Category: Other": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-29T16:15:48.609Z", "modified": "2021-04-30T13:02:19.665Z"}, {"entity": "publication", "iuid": "d4848d32e81845a799c9c4615ed3dc81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4848d32e81845a799c9c4615ed3dc81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4848d32e81845a799c9c4615ed3dc81"}}, "title": "A combination of N and S antigens with IgA and IgG measurement strengthens the accuracy of SARS-CoV-2 serodiagnostics", "authors": [{"family": "Jalkanen", "given": "Pinja", "initials": "P"}, {"family": "Pasternack", "given": "Arja", "initials": "A"}, {"family": "Maljanen", "given": "Sari", "initials": "S"}, {"family": "Mel\u00e9n", "given": "Krister", "initials": "K"}, {"family": "Kolehmainen", "given": "Pekka", "initials": "P"}, {"family": "Huttunen", "given": "Moona", "initials": "M"}, {"family": "Lundberg", "given": "Rickard", "initials": "R"}, {"family": "Tripathi", "given": "Lav", "initials": "L"}, {"family": "Khan", "given": "Hira", "initials": "H"}, {"family": "Ritvos", "given": "Mikael A", "initials": "MA"}, {"family": "Naves", "given": "Rauno", "initials": "R"}, {"family": "Haveri", "given": "Anu", "initials": "A"}, {"family": "\u00d6sterlund", "given": "Pamela", "initials": "P"}, {"family": "Kuivanen", "given": "Suvi", "initials": "S"}, {"family": "J\u00e4\u00e4skel\u00e4inen", "given": "Anne J", "initials": "AJ"}, {"family": "Kurkela", "given": "Satu", "initials": "S"}, {"family": "Lappalainen", "given": "Maija", "initials": "M"}, {"family": "Rantas\u00e4rkk\u00e4", "given": "Kaisa", "initials": "K"}, {"family": "Vuorinen", "given": "Tytti", "initials": "T"}, {"family": "Hyt\u00f6nen", "given": "Jukka", "initials": "J"}, {"family": "Waris", "given": "Matti", "initials": "M"}, {"family": "Tauriainen", "given": "Sisko", "initials": "S"}, {"family": "Ritvos", "given": "Olli", "initials": "O"}, {"family": "Kakkola", "given": "Laura", "initials": "L"}, {"family": "Julkunen", "given": "Ilkka", "initials": "I"}], "type": "journal-article", "published": "2021-04-27", "journal": {"title": "The Journal of Infectious Diseases", "issn": "0022-1899", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1093/infdis/jiab222", "pmid": null, "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-29T10:13:44.262Z", "modified": "2021-04-29T10:15:16.292Z"}, {"entity": "publication", "iuid": "4b46fb9b6a364fffb0cdb5048b5d59ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b46fb9b6a364fffb0cdb5048b5d59ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b46fb9b6a364fffb0cdb5048b5d59ca"}}, "title": "When face-to-face interviews are not possible: tips and tricks for video, telephone, online chat, and email interviews in qualitative research.", "authors": [{"family": "Saarij\u00e4rvi", "given": "Markus", "initials": "M"}, {"family": "Bratt", "given": "Ewa-Lena", "initials": "EL"}], "type": "journal article", "published": "2021-04-24", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "volume": null, "issue": null, "issn-l": null}, "abstract": "Face-to-face interviews have long been the norm for conducting qualitative interviews in healthcare research. However, the Covid-19 pandemic has accelerated the need to explore alternative methods. This, along with the swift digitalization of healthcare, has led to video, telephone, and online interactions becoming increasingly used. The use of new techniques to carry out interviews through video, telephone, and online applications all come with benefits and drawbacks. In this article, three ways of collecting data through qualitative interviews are described and their uses exemplified through a project investigating the impact of a transition program for adolescents with congenital heart disease.", "doi": "10.1093/eurjcn/zvab038", "pmid": "33893797", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "6249551"}], "notes": [], "created": "2021-04-29T15:29:20.298Z", "modified": "2021-04-29T15:29:20.308Z"}, {"entity": "publication", "iuid": "2829e953fc844de68b4eabeba69828f6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2829e953fc844de68b4eabeba69828f6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2829e953fc844de68b4eabeba69828f6"}}, "title": "SARS-CoV-2 rapid antigen test: High sensitivity to detect infectious virus.", "authors": [{"family": "Nordgren", "given": "Johan", "initials": "J"}, {"family": "Sharma", "given": "Sumit", "initials": "S"}, {"family": "Olsson", "given": "Henrik", "initials": "H"}, {"family": "J\u00e4mtberg", "given": "Mikael", "initials": "M"}, {"family": "Falkeborn", "given": "Tina", "initials": "T"}, {"family": "Svensson", "given": "Lennart", "initials": "L"}, {"family": "Hagbom", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2021-04-24", "journal": {"title": "J Clin Virol", "issn": "1873-5967", "volume": "140", "issue": null, "pages": "104846", "issn-l": null}, "abstract": "The COVID-19 pandemic has highlighted the need for rapid, cost effective and easy-to-use diagnostic tools for SARS-CoV-2 infections that can be used in point of care settings to limit disease transmission.\n\nWe evaluated two rapid antigen immunochromatographic tests, Abbott Panbio\u2122 COVID-19 Ag Rapid Test (Panbio) and Zhejiang Orient Gene/Healgen Biotech Coronavirus Ag rapid test cassette (Orient gene) for detection of infectious SARS-CoV-2.\n\nThe tests were evaluated on nasopharyngeal samples taken from individuals having respiratory and/or COVID-19 related symptoms, which had been analyzed for SARS-CoV-2 RNA using real-time PCR. In total 156 PCR-positive, and 130 (Panbio) and 176 (Orient Gene) PCR-negative samples were analyzed. Overall sensitivity and specificity were 71.8% and 100% for Panbio and 79.5% and 74.4% for the Orient Gene test respectively. The false positives by the Orient Gene test were verified as SARS-CoV-2 negative by in-house real-time PCR assay and were negative for the four seasonal coronaviruses. Subgroup analysis revealed that the antigen tests had high sensitivity for samples with Ct-values <25 (>88%) and for samples containing infectious viruses as determined by cultivation on Vero cells, 94.1% and 97.1% for the Panbio and Orient gene tests, respectively. Furthermore, both tests had a sensitivity of <50 picogram for nucleocapsid protein. No sample with a Ct-value >27 was shown to contain infectious virus.\n\nThe results indicate that the rapid antigen tests, especially the Panbio tests may be a valuable tool to detect contagious persons during the ongoing pandemic.", "doi": "10.1016/j.jcv.2021.104846", "pmid": "33971580", "labels": {"Category: Other": null, "Type: Journal article": null, "Category: Serology": null}, "xrefs": [{"db": "pii", "key": "S1386-6532(21)00113-X"}, {"db": "pmc", "key": "PMC8105081"}], "notes": [], "created": "2021-05-17T18:59:51.442Z", "modified": "2021-05-17T19:00:05.499Z"}, {"entity": "publication", "iuid": "049415536c104aac889ad2589eb7e290", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/049415536c104aac889ad2589eb7e290.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/049415536c104aac889ad2589eb7e290"}}, "title": "Post-COVID syndrome: Need to include risk of addiction in research and multi-disciplinary clinical work.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "letter", "published": "2021-04-24", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "issn-l": null, "volume": "301", "issue": null, "pages": "113961"}, "abstract": null, "doi": "10.1016/j.psychres.2021.113961", "pmid": "33957379", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(21)00258-4"}, {"db": "pmc", "key": "PMC8064891"}], "notes": [], "created": "2021-05-17T19:06:00.630Z", "modified": "2021-07-02T14:28:42.169Z"}, {"entity": "publication", "iuid": "a8d2f9e9aefb4fca8d9c02c651aecb50", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8d2f9e9aefb4fca8d9c02c651aecb50.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8d2f9e9aefb4fca8d9c02c651aecb50"}}, "title": "Cyanobacteria-From the Oceans to the Potential Biotechnological and Biomedical Applications.", "authors": [{"family": "Khalifa", "given": "Shaden A M", "initials": "SAM"}, {"family": "Shedid", "given": "Eslam S", "initials": "ES"}, {"family": "Saied", "given": "Essa M", "initials": "EM"}, {"family": "Jassbi", "given": "Amir Reza", "initials": "AR"}, {"family": "Jamebozorgi", "given": "Fatemeh H", "initials": "FH"}, {"family": "Rateb", "given": "Mostafa E", "initials": "ME"}, {"family": "Du", "given": "Ming", "initials": "M"}, {"family": "Abdel-Daim", "given": "Mohamed M", "initials": "MM"}, {"family": "Kai", "given": "Guo-Yin", "initials": "GY"}, {"family": "Al-Hammady", "given": "Montaser A M", "initials": "MAM"}, {"family": "Xiao", "given": "Jianbo", "initials": "J"}, {"family": "Guo", "given": "Zhiming", "initials": "Z"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}], "type": "journal article", "published": "2021-04-24", "journal": {"title": "Mar Drugs", "issn": "1660-3397", "volume": "19", "issue": "5", "issn-l": null}, "abstract": "Cyanobacteria are photosynthetic prokaryotic organisms which represent a significant source of novel, bioactive, secondary metabolites, and they are also considered an abundant source of bioactive compounds/drugs, such as dolastatin, cryptophycin 1, curacin toyocamycin, phytoalexin, cyanovirin-N and phycocyanin. Some of these compounds have displayed promising results in successful Phase I, II, III and IV clinical trials. Additionally, the cyanobacterial compounds applied to medical research have demonstrated an exciting future with great potential to be developed into new medicines. Most of these compounds have exhibited strong pharmacological activities, including neurotoxicity, cytotoxicity and antiviral activity against HCMV, HSV-1, HHV-6 and HIV-1, so these metabolites could be promising candidates for COVID-19 treatment. Therefore, the effective large-scale production of natural marine products through synthesis is important for resolving the existing issues associated with chemical isolation, including small yields, and may be necessary to better investigate their biological activities. Herein, we highlight the total synthesized and stereochemical determinations of the cyanobacterial bioactive compounds. Furthermore, this review primarily focuses on the biotechnological applications of cyanobacteria, including applications as cosmetics, food supplements, and the nanobiotechnological applications of cyanobacterial bioactive compounds in potential medicinal applications for various human diseases are discussed.", "doi": "10.3390/md19050241", "pmid": "33923369", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "md19050241"}], "notes": [], "created": "2021-05-04T16:23:54.908Z", "modified": "2021-05-04T16:23:54.929Z"}, {"entity": "publication", "iuid": "3cffa71e6f75463d8f3f0744bccf3afb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3cffa71e6f75463d8f3f0744bccf3afb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3cffa71e6f75463d8f3f0744bccf3afb"}}, "title": "Call for a pan-European COVID-19 response must be comprehensive - Authors' reply.", "authors": [{"family": "Priesemann", "given": "Viola", "initials": "V"}, {"family": "Brinkmann", "given": "Melanie M", "initials": "MM"}, {"family": "Ciesek", "given": "Sandra", "initials": "S"}, {"family": "Cuschieri", "given": "Sarah", "initials": "S"}, {"family": "Czypionka", "given": "Thomas", "initials": "T"}, {"family": "Giordano", "given": "Giulia", "initials": "G"}, {"family": "Hanson", "given": "Claudia", "initials": "C"}, {"family": "Hens", "given": "Niel", "initials": "N"}, {"family": "Iftekhar", "given": "Emil", "initials": "E"}, {"family": "Klimek", "given": "Peter", "initials": "P"}, {"family": "Kretzschmar", "given": "Mirjam", "initials": "M"}, {"family": "Peichl", "given": "Andreas", "initials": "A"}, {"family": "Perc", "given": "Matja\u017e", "initials": "M"}, {"family": "Sannino", "given": "Francesco", "initials": "F"}, {"family": "Schernhammer", "given": "Eva", "initials": "E"}, {"family": "Schmidt", "given": "Alexander", "initials": "A"}, {"family": "Staines", "given": "Anthony", "initials": "A"}, {"family": "Szczurek", "given": "Ewa", "initials": "E"}], "type": "letter", "published": "2021-04-24", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "397", "issue": "10284", "pages": "1541", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(21)00462-1", "pmid": "33894827", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)00462-1"}], "notes": [], "created": "2021-04-29T15:28:23.486Z", "modified": "2021-04-29T15:28:42.254Z"}, {"entity": "publication", "iuid": "985d6927c03444debef535dd9f32fad3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/985d6927c03444debef535dd9f32fad3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/985d6927c03444debef535dd9f32fad3"}}, "title": "Epidemiological analysis of 3,219 COVID-19 outbreaks in the state of Baden-Wuerttemberg, Germany.", "authors": [{"family": "Dressler", "given": "Aparna", "initials": "A"}, {"family": "Finci", "given": "Iris", "initials": "I"}, {"family": "Wagner-Wiening", "given": "Christiane", "initials": "C"}, {"family": "Eichner", "given": "Martin", "initials": "M"}, {"family": "Brockmann", "given": "Stefan O", "initials": "SO"}], "type": "journal article", "published": "2021-04-23", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "issn-l": null, "volume": null, "issue": null, "pages": "1-18"}, "abstract": null, "doi": "10.1017/S0950268821000911", "pmid": "33888172", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0950268821000911"}], "notes": [], "created": "2021-04-29T16:11:39.530Z", "modified": "2021-04-29T16:32:25.071Z"}, {"entity": "publication", "iuid": "0bc38cc4b8e84a82a44e04503c54065a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0bc38cc4b8e84a82a44e04503c54065a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0bc38cc4b8e84a82a44e04503c54065a"}}, "title": "COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system.", "authors": [{"family": "Rysz", "given": "Susanne", "initials": "S"}, {"family": "Al-Saadi", "given": "Jonathan", "initials": "J"}, {"family": "Sj\u00f6str\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Farm", "given": "Maria", "initials": "M"}, {"family": "Campoccia Jalde", "given": "Francesca", "initials": "F"}, {"family": "Platt\u00e9n", "given": "Michael6", "initials": "M"}, {"family": "Eriksson", "given": "Helen", "initials": "H"}, {"family": "Klein", "given": "Margareta", "initials": "M"}, {"family": "Vargas-Paris", "given": "Roberto", "initials": "R"}, {"family": "Nyr\u00e9n", "given": "Sven", "initials": "S"}, {"family": "Abdula", "given": "Goran", "initials": "G"}, {"family": "Ouellette", "given": "Russell", "initials": "R"}, {"family": "Granberg", "given": "Tobias", "initials": "T"}, {"family": "Jonsson Fagerlund", "given": "Malin", "initials": "M"}, {"family": "Lundberg", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2021-04-23", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "2417"}, "abstract": "SARS-CoV-2 uses ACE2, an inhibitor of the Renin-Angiotensin-Aldosterone System (RAAS), for cellular entry. Studies indicate that RAAS imbalance worsens the prognosis in COVID-19. We present a consecutive retrospective COVID-19 cohort with findings of frequent pulmonary thromboembolism (17%), high pulmonary artery pressure (60%) and lung MRI perfusion disturbances. We demonstrate, in swine, that infusing angiotensin II or blocking ACE2 induces increased pulmonary artery pressure, reduces blood oxygenation, increases coagulation, disturbs lung perfusion, induces diffuse alveolar damage, and acute tubular necrosis compared to control animals. We further demonstrate that this imbalanced state can be ameliorated by infusion of an angiotensin receptor blocker and low-molecular-weight heparin. In this work, we show that a pathophysiological state in swine induced by RAAS imbalance shares several features with the clinical COVID-19 presentation. Therefore, we propose that severe COVID-19 could partially be driven by a RAAS imbalance.", "doi": "10.1038/s41467-021-22713-z", "pmid": "33893295", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-22713-z"}], "notes": [], "created": "2021-04-26T17:40:04.765Z", "modified": "2021-04-29T15:33:57.903Z"}, {"entity": "publication", "iuid": "0efcd0187d4f4c129e1c179bfb5452d8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0efcd0187d4f4c129e1c179bfb5452d8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0efcd0187d4f4c129e1c179bfb5452d8"}}, "title": "Meal and Sleep Timing before and during the COVID-19 Pandemic: A Cross-Sectional Anonymous Survey Study from Sweden.", "authors": [{"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Brand\u00e3o", "given": "Luiz Eduardo Mateus", "initials": "LEM"}, {"family": "Merikanto", "given": "Ilona", "initials": "I"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J"}], "type": "journal article", "published": "2021-04-22", "journal": {"title": "Clocks Sleep", "issn": "2624-5175", "volume": "3", "issue": "2", "pages": "251-258", "issn-l": null}, "abstract": "The COVID-19 pandemic and related restrictions, such as stay-at-home-orders, have significantly altered daily routines and lifestyles. Given their importance for metabolic health, we herein compared sleep and meal timing parameters during vs. before the COVID-19 pandemic based on subjective recall, in an anonymous Swedish survey. Among 191 adults (mean age: 47 years; 77.5% females), we show that social jetlag, i.e., the mismatch in sleep midpoint between work and free days, was reduced by about 17 min during the pandemic compared with the pre-pandemic state ( p < 0.001). Concomitantly, respondents' sleep midpoint was shifted toward morning hours during workdays (p < 0.001). A later daily eating midpoint accompanied the shift in sleep timing (p = 0.001). This effect was mainly driven by a later scheduled first meal (p < 0.001). No difference in the timing of the day's last meal was found (p = 0.814). Although our survey was limited in terms of sample size and by being cross-sectional, our results suggest that the delay in sleep timing due to the COVID-19 pandemic was accompanied by a corresponding shift in the timing of early but not late meals.", "doi": "10.3390/clockssleep3020015", "pmid": "33921946", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "clockssleep3020015"}], "notes": [], "created": "2021-05-04T16:24:15.921Z", "modified": "2021-05-04T16:24:15.944Z"}, {"entity": "publication", "iuid": "6e1f6b9ec31a455083dcfdd8f136d90d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e1f6b9ec31a455083dcfdd8f136d90d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e1f6b9ec31a455083dcfdd8f136d90d"}}, "title": "Making Waves: Collaboration in the time of SARS-CoV-2 - rapid development of an international co-operation and wastewater surveillance database to support public health decision-making.", "authors": [{"family": "Lundy", "given": "Lian", "initials": "L"}, {"family": "Fatta-Kassinos", "given": "Despo", "initials": "D"}, {"family": "Slobodnik", "given": "Jaroslav", "initials": "J"}, {"family": "Karaolia", "given": "Popi", "initials": "P"}, {"family": "Cirka", "given": "Lubos", "initials": "L"}, {"family": "Kreuzinger", "given": "Norbert", "initials": "N"}, {"family": "Castiglioni", "given": "Sara", "initials": "S"}, {"family": "Bijlsma", "given": "Lubertus", "initials": "L"}, {"family": "Dulio", "given": "Valeria", "initials": "V"}, {"family": "Deviller", "given": "Genevi\u00e8ve", "initials": "G"}, {"family": "Lai", "given": "Foon Yin", "initials": "FY"}, {"family": "Alygizakis", "given": "Nikiforos", "initials": "N"}, {"family": "Barneo", "given": "Manuela", "initials": "M"}, {"family": "Baz-Lomba", "given": "Jose Antonio", "initials": "JA"}, {"family": "B\u00e9en", "given": "Frederic", "initials": "F"}, {"family": "C\u00edchov\u00e1", "given": "Marianna", "initials": "M"}, {"family": "Conde-P\u00e9rez", "given": "Kelly", "initials": "K"}, {"family": "Covaci", "given": "Adrian", "initials": "A"}, {"family": "Donner", "given": "Erica", "initials": "E"}, {"family": "Ficek", "given": "Andrej", "initials": "A"}, {"family": "Hassard", "given": "Francis", "initials": "F"}, {"family": "Hedstr\u00f6m", "given": "Annelie", "initials": "A"}, {"family": "Hernandez", "given": "F\u00e9lix", "initials": "F"}, {"family": "Jansk\u00e1", "given": "Veronika", "initials": "V"}, {"family": "Jellison", "given": "Kristen", "initials": "K"}, {"family": "Hofman", "given": "Jan", "initials": "J"}, {"family": "Hill", "given": "Kelly", "initials": "K"}, {"family": "Hong", "given": "Pei-Ying", "initials": "P"}, {"family": "Kasprzyk-Hordern", "given": "Barbara", "initials": "B"}, {"family": "Kolarevi\u0107", "given": "Stoimir", "initials": "S"}, {"family": "Krahulec", "given": "Jan", "initials": "J"}, {"family": "Lambropoulou", "given": "Dimitra", "initials": "D"}, {"family": "de Llanos", "given": "Rosa", "initials": "R"}, {"family": "Macku\u013eak", "given": "Tom\u00e1\u0161", "initials": "T"}, {"family": "Martinez-Garc\u00eda", "given": "Lorena", "initials": "L"}, {"family": "Mart\u00ednez", "given": "Francisco", "initials": "F"}, {"family": "Medema", "given": "Gertjan", "initials": "G"}, {"family": "Micsinai", "given": "Adrienn", "initials": "A"}, {"family": "Myrmel", "given": "Mette", "initials": "M"}, {"family": "Nasser", "given": "Mohammed", "initials": "M"}, {"family": "Niederst\u00e4tter", "given": "Harald", "initials": "H"}, {"family": "Nozal", "given": "Leonor", "initials": "L"}, {"family": "Oberacher", "given": "Herbert", "initials": "H"}, {"family": "O\u010den\u00e1\u0161kov\u00e1", "given": "V\u011bra", "initials": "V"}, {"family": "Ogorzaly", "given": "Leslie", "initials": "L"}, {"family": "Papadopoulos", "given": "Dimitrios", "initials": "D"}, {"family": "Peinado", "given": "Beatriz", "initials": "B"}, {"family": "Pitk\u00e4nen", "given": "Tarja", "initials": "T"}, {"family": "Poza", "given": "Margarita", "initials": "M"}, {"family": "Rumbo-Feal", "given": "Soraya", "initials": "S"}, {"family": "S\u00e1nchez", "given": "Maria Blanca", "initials": "MB"}, {"family": "Sz\u00e9kely", "given": "Anna J", "initials": "AJ"}, {"family": "Soltysova", "given": "Andrea", "initials": "A"}, {"family": "Thomaidis", "given": "Nikolaos S", "initials": "NS"}, {"family": "Vallejo", "given": "Juan", "initials": "J"}, {"family": "van Nuijs", "given": "Alexander", "initials": "A"}, {"family": "Ware", "given": "Vassie", "initials": "V"}, {"family": "Viklander", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-04-22", "journal": {"title": "Water Res", "issn": "1879-2448", "issn-l": "0043-1354", "volume": "199", "issue": null, "pages": "117167"}, "abstract": "The presence of SARS-CoV-2 RNA in wastewater was first reported in March 2020. Over the subsequent months, the potential for wastewater surveillance to contribute to COVID-19 mitigation programmes has been the focus of intense national and international research activities, gaining the attention of policy makers and the public. As a new application of an established methodology, focused collaboration between public health practitioners and wastewater researchers is essential to developing a common understanding on how, when and where the outputs of this non-invasive community-level approach can deliver actionable outcomes for public health authorities. Within this context, the NORMAN SCORE \"SARS-CoV-2 in sewage\" database provides a platform for rapid, open access data sharing, validated by the uploading of 276 data sets from nine countries to-date. Through offering direct access to underpinning meta-data sets (and describing its use in data interpretation), the NORMAN SCORE database is a resource for the development of recommendations on minimum data requirements for wastewater pathogen surveillance. It is also a tool to engage public health practitioners in discussions on use of the approach, providing an opportunity to build mutual understanding of the demand and supply for data and facilitate the translation of this promising research application into public health practice.", "doi": "10.1016/j.watres.2021.117167", "pmid": "34015748", "labels": {"Type: Review": null, "Funder: Vinnova": null}, "xrefs": [{"db": "pii", "key": "S0043-1354(21)00365-1"}], "notes": [], "created": "2021-05-21T17:15:44.041Z", "modified": "2021-05-21T17:24:41.177Z"}, {"entity": "publication", "iuid": "8df82413871348eeb0566de94cc812a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8df82413871348eeb0566de94cc812a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8df82413871348eeb0566de94cc812a0"}}, "title": "Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial.", "authors": [{"family": "Gunst", "given": "Jesper D", "initials": "JD"}, {"family": "Staerke", "given": "Nina B", "initials": "NB"}, {"family": "Pahus", "given": "Marie H", "initials": "MH"}, {"family": "Kristensen", "given": "Lena H", "initials": "LH"}, {"family": "Bodilsen", "given": "Jacob", "initials": "J"}, {"family": "Lohse", "given": "Nicolai", "initials": "N"}, {"family": "Dalgaard", "given": "Lars S", "initials": "LS"}, {"family": "Br\u00f8nnum", "given": "Dorthe", "initials": "D"}, {"family": "Fr\u00f6bert", "given": "Ole", "initials": "O"}, {"family": "H\u00f8nge", "given": "Bo", "initials": "B"}, {"family": "Johansen", "given": "Isik S", "initials": "IS"}, {"family": "Monrad", "given": "Ida", "initials": "I"}, {"family": "Erikstrup", "given": "Christian", "initials": "C"}, {"family": "Rosendal", "given": "Regitze", "initials": "R"}, {"family": "Vilstrup", "given": "Emil", "initials": "E"}, {"family": "Mariager", "given": "Theis", "initials": "T"}, {"family": "Bove", "given": "Dorthe G", "initials": "DG"}, {"family": "Offersen", "given": "Rasmus", "initials": "R"}, {"family": "Shakar", "given": "Shakil", "initials": "S"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "J\u00f8rgensen", "given": "Nis P", "initials": "NP"}, {"family": "Sritharan", "given": "Sajitha S", "initials": "SS"}, {"family": "Breining", "given": "Peter", "initials": "P"}, {"family": "Jespersen", "given": "S\u00f8ren", "initials": "S"}, {"family": "Mortensen", "given": "Klaus L", "initials": "KL"}, {"family": "Jensen", "given": "Mads L", "initials": "ML"}, {"family": "Kolte", "given": "Lilian", "initials": "L"}, {"family": "Frattari", "given": "Giacomo S", "initials": "GS"}, {"family": "Larsen", "given": "Carsten S", "initials": "CS"}, {"family": "Storgaard", "given": "Merete", "initials": "M"}, {"family": "Nielsen", "given": "Lars P", "initials": "LP"}, {"family": "Tolstrup", "given": "Martin", "initials": "M"}, {"family": "S\u00e6dder", "given": "Eva A", "initials": "EA"}, {"family": "\u00d8stergaard", "given": "Lars J", "initials": "LJ"}, {"family": "Ngo", "given": "Hien T T", "initials": "HTT"}, {"family": "Jensen", "given": "Morten H", "initials": "MH"}, {"family": "H\u00f8jen", "given": "Jesper F", "initials": "JF"}, {"family": "Kjolby", "given": "Mads", "initials": "M"}, {"family": "S\u00f8gaard", "given": "Ole S", "initials": "OS"}], "type": "journal article", "published": "2021-04-22", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": null, "issue": null, "pages": "100849", "issn-l": null}, "abstract": "The trans-membrane protease serine 2 (TMPRSS2) is essential for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry and infection. Efficacy and safety of TMPRSS2 inhibitors in patients with coronavirus disease 2019 (Covid-19) have not been evaluated in randomized trials.\n\nWe conducted an investigator-initiated, double-blind, randomized, placebo-controlled multicenter trial in patients hospitalized with confirmed SARS-CoV-2 infection from April 4, to December 31, 2020. Within 48 h of admission, participants were randomly assigned in a 2:1 ratio to receive the TMPRSS2 inhibitor camostat mesilate 200 mg three times daily for 5 days or placebo. The primary outcome was time to discharge or clinical improvement measured as \u22652 points improvement on a 7-point ordinal scale. Other outcomes included 30-day mortality, safety and change in oropharyngeal viral load. ClinicalTrials.gov Identifier: NCT04321096. EudraCT Number: 2020-001,200-42.\n\n137 patients were assigned to receive camostat mesilate and 68 to placebo. Median time to clinical improvement was 5 days (interquartile range [IQR], 3 to 7) in the camostat group and 5 days (IQR, 2 to 10) in the placebo group ( P = 0\u00b731). The hazard ratio for 30-day mortality in the camostat compared with the placebo group was 0\u00b782 (95% confidence interval [CI], 0\u00b724 to 2\u00b779; P = 0\u00b775). The frequency of adverse events was similar in the two groups. Median change in viral load from baseline to day 5 in the camostat group was -0\u00b722 log10 copies/mL (p <0\u00b705) and -0\u00b782 log10 in the placebo group (P <0\u00b705).\n\nUnder this protocol, camostat mesilate treatment was not associated with increased adverse events during hospitalization for Covid-19 and did not affect time to clinical improvement, progression to ICU admission or mortality.", "doi": "10.1016/j.eclinm.2021.100849", "pmid": "33903855", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(21)00129-2"}, {"db": "pmc", "key": "PMC8060682"}, {"db": "ClinicalTrials.gov", "key": "NCT04321096"}], "notes": [], "created": "2021-04-29T10:21:54.594Z", "modified": "2021-04-29T10:22:43.188Z"}, {"entity": "publication", "iuid": "5e8f9500ce5844da856060c74262a286", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e8f9500ce5844da856060c74262a286.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e8f9500ce5844da856060c74262a286"}}, "title": "Clinical outcomes and risk factors for COVID-19 among migrant populations in high-income countries: a systematic review.", "authors": [{"family": "Hayward", "given": "Sally E", "initials": "SE"}, {"family": "Deal", "given": "Anna", "initials": "A"}, {"family": "Cheng", "given": "Cherie", "initials": "C"}, {"family": "Crawshaw", "given": "Alison", "initials": "A"}, {"family": "Orcutt", "given": "Miriam", "initials": "M"}, {"family": "Vandrevala", "given": "Tushna F", "initials": "TF"}, {"family": "Norredam", "given": "Prof Marie", "initials": "PM"}, {"family": "Carballo", "given": "Manuel", "initials": "M"}, {"family": "Ciftci", "given": "Yusuf", "initials": "Y"}, {"family": "Requena-M\u00e9ndez", "given": "Ana", "initials": "A"}, {"family": "Greenaway", "given": "Chris", "initials": "C"}, {"family": "Carter", "given": "Jessica", "initials": "J"}, {"family": "Knights", "given": "Felicity", "initials": "F"}, {"family": "Mehrotra", "given": "Anushka", "initials": "A"}, {"family": "Seedat", "given": "Farah", "initials": "F"}, {"family": "Bozorgmehr", "given": "Prof Kayvan", "initials": "PK"}, {"family": "Veizis", "given": "Apostolos", "initials": "A"}, {"family": "Campos-Matos", "given": "Ines", "initials": "I"}, {"family": "Wurie", "given": "Fatima", "initials": "F"}, {"family": "McKee", "given": "Prof Martin", "initials": "PM"}, {"family": "Kumar", "given": "Prof Bernadette", "initials": "PB"}, {"family": "Hargreaves", "given": "Sally", "initials": "S"}, {"family": "ESCMID Study Group for Infections in Travellers and Migrants (ESGITM)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-04-22", "journal": {"title": "J Migr Health", "issn": "2666-6235", "issn-l": null, "volume": null, "issue": null, "pages": "100041"}, "abstract": "Migrants in high-income countries may be at increased risk of COVID-19 due to their health and social circumstances, yet the extent to which they are affected and their predisposing risk factors are not clearly understood. We did a systematic review to assess clinical outcomes of COVID-19 in migrant populations, indirect health and social impacts, and to determine key risk factors.\r\n\r\nWe did a systematic review following PRISMA guidelines (PROSPERO CRD42020222135). We searched multiple databases to 18/11/2020 for peer-reviewed and grey literature on migrants (foreign-born) and COVID-19 in 82 high-income countries. We used our international networks to source national datasets and grey literature. Data were extracted on primary outcomes (cases, hospitalisations, deaths) and we evaluated secondary outcomes on indirect health and social impacts and risk factors using narrative synthesis.\r\n\r\n3016 data sources were screened with 158 from 15 countries included in the analysis (35 data sources for primary outcomes: cases [21], hospitalisations [4]; deaths [15]; 123 for secondary outcomes). We found that migrants are at increased risk of infection and are disproportionately represented among COVID-19 cases. Available datasets suggest a similarly disproportionate representation of migrants in reported COVID-19 deaths, as well as increased all-cause mortality in migrants in some countries in 2020. Undocumented migrants, migrant health and care workers, and migrants housed in camps have been especially affected. Migrants experience risk factors including high-risk occupations, overcrowded accommodation, and barriers to healthcare including inadequate information, language barriers, and reduced entitlement.\r\n\r\nMigrants in high-income countries are at high risk of exposure to, and infection with, COVID-19. These data are of immediate relevance to national public health and policy responses to the pandemic. Robust data on testing uptake and clinical outcomes in migrants, and barriers and facilitators to COVID-19 vaccination, are urgently needed, alongside strengthening engagement with diverse migrant groups.", "doi": "10.1016/j.jmh.2021.100041", "pmid": "33903857", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2666-6235(21)00008-8"}, {"db": "pmc", "key": "PMC8061095"}], "notes": [], "created": "2021-04-29T10:21:10.252Z", "modified": "2021-07-14T07:44:19.630Z"}, {"entity": "publication", "iuid": "b21b195ee3fb4aa5bf014ac1781bed44", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b21b195ee3fb4aa5bf014ac1781bed44.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b21b195ee3fb4aa5bf014ac1781bed44"}}, "title": "COVID-19 in pregnancy - characteristics and outcomes of pregnant women admitted to hospital because of SARS-CoV-2 infection in the Nordic countries.", "authors": [{"family": "Engjom", "given": "Hilde", "initials": "H"}, {"family": "Aabakke", "given": "Anna Jm", "initials": "AJ"}, {"family": "Klungs\u00f8yr", "given": "Kari", "initials": "K"}, {"family": "Svanvik", "given": "Teresia", "initials": "T"}, {"family": "\u00c4yr\u00e4s", "given": "Outi", "initials": "O"}, {"family": "Jonasdottir", "given": "Eva", "initials": "E"}, {"family": "Thurn", "given": "Lars", "initials": "L"}, {"family": "Jones", "given": "Elin", "initials": "E"}, {"family": "Pettersson", "given": "Karin", "initials": "K"}, {"family": "Nyfl\u00f8t", "given": "Lill Trine", "initials": "LT"}, {"family": "Al-Zirqi", "given": "Iqbal", "initials": "I"}, {"family": "Vangen", "given": "Siri", "initials": "S"}, {"family": "J\u00fal\u00edusson", "given": "P\u00e9tur B", "initials": "PB"}, {"family": "K\u00e4ll\u00e9n", "given": "Karin", "initials": "K"}, {"family": "Gissler", "given": "Mika", "initials": "M"}, {"family": "Krebs", "given": "Lone", "initials": "L"}], "type": "journal article", "published": "2021-04-22", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": null, "issue": null, "issn-l": "0001-6349"}, "abstract": "Population-based studies about the consequences of SARS-CoV-2 infection (COVID-19) in pregnancy are few and have limited generalizability to the Nordic population and health care systems.\n\nThis study examines pregnant women with COVID-19 in the five Nordic countries. Pregnant women were included if they were admitted to hospital between March 1 and June 30, 2020 and had a positive SARS-CoV-2 PCR test 14 days or fewer prior to the admission. Cause of admission was classified as obstetric or COVID-19 related.\n\nIn the study areas, 214 pregnant women with a positive test were admitted to hospital, of which 56 women needed hospital care due to COVID-19. The risk of admission due to COVID-19 was 0.4 per 1000 deliveries in Denmark, Finland, and Norway and 3.8 per 1000 deliveries in the Swedish regions. Women hospitalized because of COVID-19 were more frequently obese (P < 0.001) and had migrant background (P < 0.001) compared to the total population of women who delivered in 2018. Twelve women (21.4%) needed intensive care. Among the 56 women admitted due to COVID-19, 48 women delivered 51 infants. Preterm delivery (n=12, 25%, P < 0.001) and cesarean delivery (n=21, 43,8%, P < 0.001) were more frequent in women with COVID-19 compared to the women who delivered in 2018. No maternal deaths, stillbirths or neonatal deaths were reported.\n\nThe risk of admission due to COVID-19 disease in pregnancy was low in the Nordic countries. A fifth of the women required intensive care and we observed higher rates of preterm and cesarean deliveries. National public health policies appear to have had an impact on the risk of admission due to severe COVID-19 disease in pregnancy. Nordic collaboration is important in collecting robust data and assessing rare outcomes.", "doi": "10.1111/aogs.14160", "pmid": "33885150", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-23T04:26:33.875Z", "modified": "2021-04-23T04:26:33.878Z"}, {"entity": "publication", "iuid": "0eccaa022fbb4b4b9097af6451d6dcfb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0eccaa022fbb4b4b9097af6451d6dcfb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0eccaa022fbb4b4b9097af6451d6dcfb"}}, "title": "The International Academy of Health Sciences Informatics (IAHSI): 2020 Report.", "authors": [{"family": "Haux", "given": "Reinhold", "initials": "R"}, {"family": "Ball", "given": "Marion J", "initials": "MJ"}, {"family": "Hersh", "given": "William R", "initials": "WR"}, {"family": "Huesing", "given": "Elaine", "initials": "E"}, {"family": "Kimura", "given": "Michio", "initials": "M"}, {"family": "Koch", "given": "Sabine", "initials": "S"}, {"family": "Martin-Sanchez", "given": "Fernando", "initials": "F"}, {"family": "Otero", "given": "Paula", "initials": "P"}], "type": "journal article", "published": "2021-04-21", "journal": {"title": "Yearb Med Inform", "issn": "2364-0502", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To summarize the major activities of the International Academy of Health Sciences Informatics (IAHSI) in the 2020 time period and to welcome its 2020 Class of Fellows.\r\n\r\nReport from the members of the Academy's Board.\r\n\r\nDue to the SARS-CoV-2 pandemic, both Plenary meetings in 2020 had to be organized as virtual meetings. Scientific discussions, focusing on mobilizing computable biomedical knowledge and on data standards and interoperability formed major parts of these meetings. A statement on the use of informatics in pandemic situations was elaborated and sent to the World Health Organization. A panel on data standards and interoperability started its work. 34 Fellows were welcomed in the 2020 Class of Fellows so that the Academy now consists of 179 members.\r\n\r\nThere was a shift from supporting to strategic activities in the Academy's work. After having achieved organizational stability, the Academy can now focus on its strategic work and so on its main objective.", "doi": "10.1055/s-0041-1726479", "pmid": "33882593", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-04-23T04:37:32.554Z", "modified": "2021-07-14T07:42:34.648Z"}, {"entity": "publication", "iuid": "58dc6579e3f346f29a8468c2230d99ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/58dc6579e3f346f29a8468c2230d99ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/58dc6579e3f346f29a8468c2230d99ca"}}, "title": "Opportunities and Challenges for the Next Phase of Enhanced Recovery After Surgery: A Review.", "authors": [{"family": "Ljungqvist", "given": "Olle", "initials": "O"}, {"family": "de Boer", "given": "Hans D", "initials": "HD"}, {"family": "Balfour", "given": "Angie", "initials": "A"}, {"family": "Fawcett", "given": "William J", "initials": "WJ"}, {"family": "Lobo", "given": "Dileep N", "initials": "DN"}, {"family": "Nelson", "given": "Gregg", "initials": "G"}, {"family": "Scott", "given": "Michael J", "initials": "MJ"}, {"family": "Wainwright", "given": "Thomas W", "initials": "TW"}, {"family": "Demartines", "given": "Nicolas", "initials": "N"}], "type": "journal article", "published": "2021-04-21", "journal": {"title": "JAMA Surg", "issn": "2168-6262", "volume": null, "issue": null, "issn-l": null}, "abstract": "Enhanced Recovery After Surgery (ERAS) is a global surgical quality improvement initiative now firmly entrenched within the field of perioperative care. Although ERAS is associated with significant clinical outcome improvements and cost savings in numerous surgical specialties, several opportunities and challenges deserve further discussion.\n\nUptake and implementation of ERAS Society guidelines, together with ERAS-related research, have increased exponentially since the inception of the ERAS movement. Opportunities to further improve patient outcomes include addressing frailty, optimizing nutrition, prehabilitation, correcting preoperative anemia, and improving uptake of ERAS worldwide, including in low- and middle-income countries. Challenges facing enhanced recovery today include implementation, carbohydrate loading, reversal of neuromuscular blockade, and bowel preparation. The COVID-19 pandemic poses both a challenge and an opportunity for ERAS.\n\nTo date, ERAS has achieved significant benefit for patients and health systems; however, improvements are still needed, particularly in the areas of patient optimization and systematic implementation. During this time of global crisis, the ERAS method of delivering care is required to take surgery and anesthesia to the next level and bring improvements in outcomes to both patients and health systems.", "doi": "10.1001/jamasurg.2021.0586", "pmid": "33881466", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "2778928"}], "notes": [], "created": "2021-04-23T04:39:04.745Z", "modified": "2021-04-23T04:39:04.767Z"}, {"entity": "publication", "iuid": "2531ed7bcaaa4d80b39e4f02c542c107", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2531ed7bcaaa4d80b39e4f02c542c107.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2531ed7bcaaa4d80b39e4f02c542c107"}}, "title": "Enhancing Safety During a Pandemic Using Virtual Care Remote Monitoring Technologies and UML Modeling.", "authors": [{"family": "Borycki", "given": "Elizabeth M", "initials": "EM"}, {"family": "Kushniruk", "given": "Andre W", "initials": "AW"}, {"family": "Kletke", "given": "Ryan", "initials": "R"}, {"family": "Vimarlund", "given": "Vivian", "initials": "V"}, {"family": "Senathirajah", "given": "Yalini", "initials": "Y"}, {"family": "Quintana", "given": "Yuri", "initials": "Y"}], "type": "journal article", "published": "2021-04-21", "journal": {"title": "Yearb Med Inform", "issn": "2364-0502", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "This paper describes a methodology for gathering requirements and early design of remote monitoring technology (RMT) for enhancing patient safety during pandemics using virtual care technologies. As pandemics such as COrona VIrus Disease (COVID-19) progress there is an increasing need for effective virtual care and RMT to support patient care while they are at home.\r\n\r\nThe authors describe their work in conducting literature reviews by searching PubMed.gov and the grey literature for articles, and government websites with guidelines describing the signs and symptoms of COVID-19, as well as the progression of the disease. The reviews focused on identifying gaps where RMT could be applied in novel ways and formed the basis for the subsequent modelling of use cases for applying RMT described in this paper.\r\n\r\nThe work was conducted in the context of a new Home of the Future laboratory which has been set up at the University of Victoria. The literature review led to the development of a number of object-oriented models for deploying RMT. This modeling is being used for a number of purposes, including for education of students in health infomatics as well as testing of new use cases for RMT with industrial collaborators and projects within the smart home of the future laboratory.\r\n\r\nObject-oriented modeling, based on analysis of gaps in the literature, was found to be a useful approach for describing, communicating and teaching about potential new uses of RMT.", "doi": "10.1055/s-0041-1726485", "pmid": "33882599", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-04-23T04:35:17.857Z", "modified": "2021-07-14T07:40:56.626Z"}, {"entity": "publication", "iuid": "c36b83f5047b46e28e2c5e70b287efd5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c36b83f5047b46e28e2c5e70b287efd5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c36b83f5047b46e28e2c5e70b287efd5"}}, "title": "Colorimetric isothermal nucleic acid detection of SARS-CoV-2 with dye combination.", "authors": [{"family": "Wu", "given": "Shanshan", "initials": "S"}, {"family": "Liu", "given": "Xiyang", "initials": "X"}, {"family": "Ye", "given": "Shenglong", "initials": "S"}, {"family": "Liu", "given": "Jianmin", "initials": "J"}, {"family": "Zheng", "given": "Wei", "initials": "W"}, {"family": "Dong", "given": "Xue", "initials": "X"}, {"family": "Yin", "given": "Xiushan", "initials": "X"}], "type": "journal article", "published": "2021-04-21", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": null, "issue": null, "pages": "e06886", "issn-l": null}, "abstract": "RT-LAMP detection of SARS-CoV-2 has been demonstrated to be a valuable diagnostic method for the diagnosis of COVID-19 1,2, which can rapidly screen carriers of the virus to effectively control the spread of the SARS-CoV-2. Here, we present a combination of dyes for isothermal detection of SARS-CoV-2 as a commercial alternative, with expanded colorimetric spectrum. We compared them with commercial reagents and proved their suitability and sensitivity through clinical RNA samples. In addition, together with commercial single dye indicators, we believe the expanded color spectrum developed here as an indicator of rapid detection will promote the diagnosis of COVID-19.", "doi": "10.1016/j.heliyon.2021.e06886", "pmid": "33903853", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)00989-0"}, {"db": "pmc", "key": "PMC8059943"}], "notes": [], "created": "2021-04-29T10:24:05.235Z", "modified": "2021-04-29T10:24:05.246Z"}, {"entity": "publication", "iuid": "a1dd881e061043cdbf6c5d279d0cd195", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a1dd881e061043cdbf6c5d279d0cd195.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a1dd881e061043cdbf6c5d279d0cd195"}}, "title": "Utilization of traditional medicine and its integration into the healthcare system in Qokolweni, South Africa; prospects for enhanced universal health coverage.", "authors": [{"family": "Mutola", "given": "Sianga", "initials": "S"}, {"family": "Pemunta", "given": "Ngambouk Vitalis", "initials": "NV"}, {"family": "Ngo", "given": "Ngo Valery", "initials": "NV"}], "type": "journal article", "published": "2021-04-20", "journal": {"title": "Complement Ther Clin Pract", "issn": "1873-6947", "issn-l": null, "volume": "43", "issue": null, "pages": "101386"}, "abstract": "Despite the WHO providing a framework for the integration of traditional medicines into the health systems with pandemics like HIV/AIDS and the COVID-19, most countries are yet to adopt the recommendations. This study explored why the integration of traditional medicines with the biomedical healthcare system in Qokolweni in Eastern Cape, South Africa was stalling. The research employed qualitative research methods; participant observation and in-depth ethnographic interviews of community members, traditional healers, and nurses. The study found that: traditional medicines are widely used in Qokolweni due to accessibility and long-built trust; the practice is broad and not certified. To achieve the integration of traditional medicine into the conventional health systems, the central government needs to show political will by setting up regulatory strategies that provide for the scientific evaluation and certification of traditional medicines. This will build confidence among biomedical scientists and health practitioners, thereby fostering easy collaboration and integration.", "doi": "10.1016/j.ctcp.2021.101386", "pmid": "33895465", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1744-3881(21)00085-2"}], "notes": [], "created": "2021-04-29T15:27:43.729Z", "modified": "2021-07-14T07:35:30.273Z"}, {"entity": "publication", "iuid": "0ca0ff0b36104042b3ab3ee645154f46", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ca0ff0b36104042b3ab3ee645154f46.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ca0ff0b36104042b3ab3ee645154f46"}}, "title": "SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses.", "authors": [{"family": "Mandolesi", "given": "Marco", "initials": "M"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Ma", "given": "Junjie", "initials": "J"}, {"family": "Pushparaj", "given": "Pradeepa", "initials": "P"}, {"family": "Perez Vidakovics", "given": "Laura", "initials": "L"}, {"family": "Kim", "given": "Changil", "initials": "C"}, {"family": "\u00c0dori", "given": "Monika", "initials": "M"}, {"family": "Lenart", "given": "Klara", "initials": "K"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "Castro Dopico", "given": "Xaquin", "initials": "X"}, {"family": "Coquet", "given": "Jonathan M", "initials": "JM"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Murrell", "given": "Ben", "initials": "B"}], "type": "journal article", "published": "2021-04-20", "journal": {"title": "Cell Rep Med", "issn": "2666-3791", "issn-l": "2666-3791", "volume": "2", "issue": "4", "pages": "100252"}, "abstract": "The outbreak and spread of SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2) is a current global health emergency, and effective prophylactic vaccines are needed urgently. The spike glycoprotein of SARS-CoV-2 mediates entry into host cells, and thus is the target of neutralizing antibodies. Here, we show that adjuvanted protein immunization with soluble SARS-CoV-2 spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaques, with neutralizing antibody titers exceeding those typically measured in SARS-CoV-2 seropositive humans by more than one order of magnitude. Neutralizing antibody responses were observed after a single dose, with exceptionally high titers achieved after boosting. A follow-up to monitor the waning of the neutralizing antibody responses in rhesus macaques demonstrated durable responses that were maintained at high and stable levels at least 4 months after boosting. These data support the development of adjuvanted SARS-CoV-2 prefusion-stabilized spike protein subunit vaccines.", "doi": "10.1016/j.xcrm.2021.100252", "pmid": "33842900", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null, "Funder: H2020": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S2666-3791(21)00068-9"}, {"db": "pmc", "key": "PMC8020888"}], "notes": [], "created": "2021-04-13T09:35:47.773Z", "modified": "2021-09-27T12:29:50.595Z"}, {"entity": "publication", "iuid": "a05ae0b55843422eb39e3a7ea4e21182", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a05ae0b55843422eb39e3a7ea4e21182.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a05ae0b55843422eb39e3a7ea4e21182"}}, "title": "Internet-Related Behaviors and Psychological Distress Among Schoolchildren During the COVID-19 School Hiatus", "authors": [{"family": "Chen", "given": "Chao Ying", "initials": "CY"}, {"family": "Chen", "given": "I Hua", "initials": "IH"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Lin", "given": "Chung Ying", "initials": "CY"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}], "type": "journal-article", "published": "2021-04-20", "journal": {"title": "Cyberpsychology, Behavior, and Social Networking", "issn": "2152-2715", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1089/cyber.2020.0497", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-04-23T04:41:04.022Z", "modified": "2021-04-23T04:41:04.044Z"}, {"entity": "publication", "iuid": "6635da3d214446ccba6addfe21442f84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6635da3d214446ccba6addfe21442f84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6635da3d214446ccba6addfe21442f84"}}, "title": "Cell type resolved quantitative proteomics map of interferon response against SARS-CoV-2.", "authors": [{"family": "Saccon", "given": "Elisa", "initials": "E"}, {"family": "Chen", "given": "Xi", "initials": "X"}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "Rodriguez", "given": "Jimmy Esneider", "initials": "JE"}, {"family": "Szekely", "given": "Laszlo", "initials": "L"}, {"family": "Vinhas", "given": "Beatriz S\u00e1", "initials": "BS"}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}, {"family": "Frisan", "given": "Teresa", "initials": "T"}, {"family": "V\u00e9gv\u00e1ri", "given": "\u00c1kos", "initials": "\u00c1"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}, {"family": "Gupta", "given": "Soham", "initials": "S"}], "type": "journal article", "published": "2021-04-20", "journal": {"title": "iScience", "issn": "2589-0042", "issn-l": "2589-0042", "volume": "24", "issue": "5", "pages": "102420"}, "abstract": "The commonly used laboratory cell lines are the first line of experimental models to study the pathogenicity and performing antiviral assays for emerging viruses. Here, we assessed the tropism and cytopathogenicity of the first Swedish isolate of SARS-CoV-2 in six different human cell lines, compared their growth characteristics and performed quantitative proteomics for the susceptible cell lines. Overall, Calu-3, Caco2, Huh7, and 293FT cell lines showed a high to moderate level of susceptibility to SARS-CoV-2. In Caco2 cells the virus can achieve high titers in the absence of any prominent cytopathic effect. The protein abundance profile during SARS-CoV-2 infection revealed cell-type-specific regulation of cellular pathways. Type-I interferon signaling was identified as the common dysregulated cellular response in Caco2, Calu-3 and Huh7 cells. Together, our data shows cell-type specific variability for cytopathogenicity, susceptibility and cellular response to SARS-CoV-2 and provide important clues to guide future studies.", "doi": "10.1016/j.isci.2021.102420", "pmid": "33898942", "labels": {"Type: Journal article": null, "Funder: H2020": null, "Funder: VR": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(21)00388-6"}, {"db": "pmc", "key": "PMC8056843"}], "notes": [], "created": "2021-04-29T10:27:34.511Z", "modified": "2021-08-25T14:31:17.789Z"}, {"entity": "publication", "iuid": "7aa42797dd3049668c25bbdafe828ba2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7aa42797dd3049668c25bbdafe828ba2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7aa42797dd3049668c25bbdafe828ba2"}}, "title": "COVID-19 as the sole cause of death is uncommon in frail home healthcare individuals: a population-based study.", "authors": [{"family": "Nilsson", "given": "Lena", "initials": "L"}, {"family": "Andersson", "given": "Christer", "initials": "C"}, {"family": "Sj\u00f6dahl", "given": "Rune", "initials": "R"}], "type": "journal article", "published": "2021-04-20", "journal": {"title": "BMC Geriatr", "issn": "1471-2318", "issn-l": null, "volume": "21", "issue": "1", "pages": "262"}, "abstract": "During the first pandemic wave, Sweden experienced a high mortality rate. Home healthcare reflects a group of people especially vulnerable to coronavirus disease 2019 (COVID-19). We aimed to evaluate the pattern of comorbidity and frailty in a group of individuals having fatal outcomes in home healthcare during the COVID-19 pandemic March to September 2020, and to assess the contribution of COVID-19 in the fatal outcomes.\r\n\r\nA cohort of adults with confirmed COVID-19 diagnosis that deceased in home healthcare between March and September 2020 were analysed in a retrospective study comprising home healthcare in 136 facilities in one Swedish county. Main outcome measures were comorbidity and frailty.\r\n\r\nOne hundred fifty-five individuals (88 women, 67 men) aged 57-106 (median 88) years were included in the analysis. Nine had considerable frailty (ability to perform various activities of daily living but confined to bed or chair on occasion) and the remaining 146 had severe frailty (unable to perform activities of daily living and/or confined to bed or chair; dementia necessitating care). Three or more diagnoses besides COVID-19 were present in 142 individuals and another eight had two diagnoses in addition to COVID-19. In 20 (13%) individuals, COVID-19 was assessed as the principal cause of death, in 100 (64.5%) a contributing cause, and for the remaining 35 (22.5%) death was probably caused by another comorbidity. This seemed to change over the course of the COVID - 19 pandemic, with its contributing role decreasing from the middle of the summer.\r\n\r\nDeath in home healthcare during the first wave of the pandemic mostly affected individuals with severe frailty and comorbidity at very advanced ages. One fifth of the individuals who died in home health care had another cause than Covid-19.\r\n\r\nClinical Trials.gov NCT04642196 date 24/11/2020.", "doi": "10.1186/s12877-021-02176-z", "pmid": "33879078", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12877-021-02176-z"}, {"db": "ClinicalTrials.gov", "key": "NCT04642196"}], "notes": [], "created": "2021-04-23T04:39:25.834Z", "modified": "2021-07-14T07:38:36.859Z"}, {"entity": "publication", "iuid": "7b8ac0478dd64503b3ce0f6d32c35cfa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b8ac0478dd64503b3ce0f6d32c35cfa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b8ac0478dd64503b3ce0f6d32c35cfa"}}, "title": "COVID-19 and municipal solid waste (MSW) management: a review", "authors": [{"family": "Das", "given": "Atanu Kumar", "initials": "AK"}, {"family": "Islam", "given": "Md Nazrul", "initials": "MN"}, {"family": "Billah", "given": "Md Morsaline", "initials": "MM"}, {"family": "Sarker", "given": "Asim", "initials": "A"}], "type": "journal-article", "published": "2021-04-20", "journal": {"title": "Environ Sci Pollut Res", "issn": "0944-1344", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1007/s11356-021-13914-6", "pmid": null, "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-04-23T04:42:33.639Z", "modified": "2021-04-23T04:42:33.662Z"}, {"entity": "publication", "iuid": "71f835534d1d490792921196d40f951a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/71f835534d1d490792921196d40f951a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/71f835534d1d490792921196d40f951a"}}, "title": "A Multi-Criteria Framework for Pandemic Response Measures.", "authors": [{"family": "Ekenberg", "given": "Love", "initials": "L"}, {"family": "Mihai", "given": "Adriana", "initials": "A"}, {"family": "Fasth", "given": "Tobias", "initials": "T"}, {"family": "Komendantova", "given": "Nadejda", "initials": "N"}, {"family": "Danielson", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2021-04-20", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "issue": null, "pages": "583706", "issn-l": "2296-2565"}, "abstract": "In managing the COVID-19 pandemic, several compelling narratives seem to have played a significant role in the decision-making processes regarding which risk mitigation and management measures to implement. Many countries were to a large extent unprepared for such a situation, even though predictions about a significant probability for a pandemic to occur existed, and national governments of several countries often acted in an uncoordinated manner, which resulted in many inconsistencies in the disaster risk reduction processes. Limited evidence has also made room for strategic narratives meant to persuade the public of the chosen set of actions, even though the degree of uncertainty regarding the outcomes of these was high, further complicating the situation. In this article, we assume a normative standpoint regarding rhapsodic decision making and suggest an integrated framework for a more elaborated decision analysis under the ambiguity of how to contain the virus spread from a policy point of view, while considering epidemiologic estimations and socioeconomic factors in a multi-stakeholder-multi-criteria context based on a co-creative work process for eliciting attitudes, perceptions, as well as preferences amongst relevant stakeholder groups. The framework, applied in our paper on Romania for demonstrative purposes, is used for evaluating mitigation measures for catastrophic events such as the COVID-19 situation, to mobilize better response strategies for future scenarios related to pandemics and other hazardous events, as well as to structure the production and analysis of narratives on the current pandemic effects.", "doi": "10.3389/fpubh.2021.583706", "pmid": "33968871", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC8096778"}], "notes": [], "created": "2021-05-17T19:03:26.840Z", "modified": "2021-05-17T19:03:26.852Z"}, {"entity": "publication", "iuid": "27ead992a7654577962986e6513c266b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27ead992a7654577962986e6513c266b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27ead992a7654577962986e6513c266b"}}, "title": "The Impact of Coronavirus (COVID-19) Related Public-Health Measures on Training Behaviours of Individuals Previously Participating in Resistance Training: A Cross-Sectional Survey Study", "authors": [{"family": "Steele", "given": "James", "initials": "J"}, {"family": "Androulakis-Korakakis", "given": "Patroklos", "initials": "P"}, {"family": "Carlson", "given": "Luke", "initials": "L"}, {"family": "Williams", "given": "David", "initials": "D"}, {"family": "Phillips", "given": "Stuart", "initials": "S"}, {"family": "Smith", "given": "Dave", "initials": "D"}, {"family": "Schoenfeld", "given": "Brad J", "initials": "BJ"}, {"family": "Loenneke", "given": "Jeremy P", "initials": "JP"}, {"family": "Winett", "given": "Richard", "initials": "R"}, {"family": "Abe", "given": "Takashi", "initials": "T"}, {"family": "Dufour", "given": "St\u00e9phane", "initials": "S"}, {"family": "Franchi", "given": "Martino V", "initials": "MV"}, {"family": "Sarto", "given": "Fabio", "initials": "F"}, {"family": "Lundberg", "given": "Tommy R", "initials": "TR"}, {"family": "Gentil", "given": "Paulo", "initials": "P"}, {"family": "Kvorning", "given": "Thue", "initials": "T"}, {"family": "Giessing", "given": "J\u00fcrgen", "initials": "J"}, {"family": "Sedliak", "given": "Milan", "initials": "M"}, {"family": "Paoli", "given": "Antonio", "initials": "A"}, {"family": "Spotswood", "given": "Fiona", "initials": "F"}, {"family": "Lucas", "given": "Alex", "initials": "A"}, {"family": "Fisher", "given": "James P", "initials": "JP"}], "type": "journal-article", "published": "2021-04-19", "journal": {"title": "Sports Med", "issn": "1179-2035", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": "Understanding the impact of lockdown upon resistance training (RT), and how people adapted their RT behaviours, has implications for strategies to maintain engagement in similar positive health behaviours. Further, doing so will provide a baseline for investigation of the long-term effects of these public health measures upon behaviours and perceptions, and facilitate future follow-up study.\r\n\r\nTo determine how the onset of coronavirus (COVID-19), and associated 'lockdown', affected RT behaviours, in addition to motivation, perceived effectiveness, enjoyment, and intent to continue, in those who regularly performed RT prior to the pandemic.\r\n\r\nWe conducted an observational, cross-sectional study using online surveys in multiple languages (English, Danish, French, German, Italian, Portuguese, Slovakian, Swedish, and Japanese) distributed across social media platforms and through authors' professional and personal networks. Adults (n = 5389; median age = 31 years [interquartile range (IQR) = 25, 38]), previously engaged in RT prior to lockdown (median prior RT experience = 7 years [IQR = 4, 12]) participated. Outcomes were self-reported RT behaviours including: continuation of RT during lockdown, location of RT, purchase of specific equipment for RT, method of training, full-body or split routine, types of training, repetition ranges, exercise number, set volumes (per exercise and muscle group), weekly frequency of training, perception of effort, whether training was planned/recorded, time of day, and training goals. Secondary outcomes included motivation, perceived effectiveness, enjoyment, and intent to continue RT.\r\n\r\nA majority of individuals (82.8%) maintained participation in RT during-lockdown. Marginal probabilities from generalised linear models and generalised estimating equations for RT behaviours were largely similar from pre- to during-lockdown. There was reduced probability of training in privately owned gyms (~ 59% to ~ 7%) and increased probability of training at home (~ 18% to ~ 89%); greater probability of training using a full-body routine (~ 38% to ~ 51%); reduced probability of resistance machines (~ 66% to ~ 13%) and free weight use (~ 96% to ~ 81%), and increased probability of bodyweight training (~ 62% to ~ 82%); reduced probability of moderate repetition ranges (~ 62-82% to ~ 55-66%) and greater probability of higher repetition ranges (~ 27% to ~ 49%); and moderate reduction in the perception of effort experienced during-training (r = 0.31). Further, individuals were slightly less likely to plan or record training during lockdown and many changed their training goals. Additionally, perceived effectiveness, enjoyment, and likelihood of continuing current training were all lower during-lockdown.\r\n\r\nThose engaged in RT prior to lockdown these behaviours with only slight adaptations in both location and types of training performed. However, people employed less effort, had lower motivation, and perceived training as less effective and enjoyable, reporting their likelihood of continuing current training was similar or lower than pre-lockdown. These results have implications for strategies to maintain engagement in positive health behaviours such as RT during-restrictive pandemic-related public health measures. PRE-REGISTRATION: https://osf.io/qcmpf .\r\n\r\nThe preprint version of this work is available on SportR\u03c7iv: https://osf.io/preprints/sportrxiv/b8s7e/ .", "doi": "10.1007/s40279-021-01438-5", "pmid": "33871831", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "URL", "key": "https://osf.io/xhryf/", "description": "Dataset: Survey data"}], "notes": [], "created": "2021-04-20T17:54:09.535Z", "modified": "2021-07-14T10:59:51.720Z"}, {"entity": "publication", "iuid": "104de2c0ff24467faa96e866ae338d06", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/104de2c0ff24467faa96e866ae338d06.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/104de2c0ff24467faa96e866ae338d06"}}, "title": "ECG with Prior Myocardial Infarction Pattern or acute ST-T Pathology is Associated with Death in Critically Ill COVID-19 Patients", "authors": [{"family": "Rosen", "given": "Jacob", "initials": "J"}, {"family": "Noreland", "given": "Maria", "initials": "M"}, {"family": "Stattin", "given": "Karl", "initials": "K"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Malinovschi", "given": "Andrei", "initials": "A"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}], "type": "posted-content", "published": "2021-04-19", "journal": {"title": "Research Square", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.21203/rs.3.rs-419853/v1", "pmid": null, "labels": {"Funder: VR": null, "Type: Preprint": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.17044/scilifelab.14229410.v1", "description": "Metadata record"}], "notes": [], "created": "2021-06-09T12:05:22.522Z", "modified": "2021-06-18T09:19:34.572Z"}, {"entity": "publication", "iuid": "3840116225c543e5a738388f958bb923", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3840116225c543e5a738388f958bb923.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3840116225c543e5a738388f958bb923"}}, "title": "Cause of death based on systematic postmortem studies in patients with positive SARS\u2010CoV2 tissue PCR during the COVID\u201019 pandemic", "authors": [{"family": "Romanova", "given": "Elena S", "initials": "ES"}, {"family": "Vasilyev", "given": "Valery V", "initials": "VV"}, {"family": "Startseva", "given": "Galina", "initials": "G"}, {"family": "Karev", "given": "Vadim", "initials": "V"}, {"family": "Rybakova", "given": "Margarita G", "initials": "MG"}, {"family": "Platonov", "given": "Pyotr G", "initials": "PG"}], "type": "journal-article", "published": "2021-04-19", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1111/joim.13300", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-20T17:53:20.904Z", "modified": "2021-04-20T17:53:20.921Z"}, {"entity": "publication", "iuid": "38bb5376ea5b44bea12092dbca89831b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38bb5376ea5b44bea12092dbca89831b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38bb5376ea5b44bea12092dbca89831b"}}, "title": "Why COVID-19 strengthens the case to scale up assault on non-communicable diseases: role of health professionals including physical therapists in mitigating pandemic waves.", "authors": [{"family": "Dean", "given": "Elizabeth", "initials": "E"}, {"family": "Skinner", "given": "Margot", "initials": "M"}, {"family": "Yu", "given": "Homer Peng-Ming", "initials": "HP"}, {"family": "Jones", "given": "Alice Ym", "initials": "AY"}, {"family": "Gosselink", "given": "Rik", "initials": "R"}, {"family": "S\u00f6derlund", "given": "Anne", "initials": "A"}], "type": "journal article", "published": "2021-04-16", "journal": {"title": "AIMS Public Health", "issn": "2327-8994", "volume": "8", "issue": "2", "pages": "369-375", "issn-l": null}, "abstract": "As SARS-CoV-2, the virus responsible for COVID-19, spread globally, the most severely affected sub-populations were the elderly and those with multi-morbidity largely related to non-communicable diseases (NCDs), e.g., heart disease, hypertension, type 2 diabetes, obesity. NCDs are largely preventable with healthy nutrition, regular activity, and not smoking. This perspective outlines the rationale for health professionals' including physical therapists' role in reducing COVID-19 susceptibility. Evidence is synthesized supporting the pro-inflammatory effects of the western diet, increasingly consumed globally, inactivity, and smoking; and the immune-boosting, anti-inflammatory effects of a whole food plant-based diet, regular physical activity, and not smoking. An increased background of chronic low-grade systemic inflammation associated with unhealthy lifestyle practices appears implicated in an individual's susceptibility to SARS-CoV-2. It is timely to re-double efforts across healthcare sectors to reduce the global prevalence of NCDs on two fronts: one, to reduce SARS-CoV-2 susceptibility; and two, to reduce the impact of subsequent waves given high blood pressure and blood sugar, common in people with multi-morbidity, can be improved within days/weeks with anti-inflammatory healthy lifestyle practices, and weight loss and atherosclerosis reduction/reversal, within months/years. With re-doubled efforts to control NCD risk factors, subsequent waves could be less severe. Health professionals including physical therapists have a primary role in actively leading this initiative.", "doi": "10.3934/publichealth.2021028", "pmid": "34017898", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "publichealth-08-02-028"}, {"db": "pmc", "key": "PMC8116194"}], "notes": [], "created": "2021-05-29T16:25:31.820Z", "modified": "2021-05-29T16:25:31.843Z"}, {"entity": "publication", "iuid": "f3ad0ee0464842b3ae6ef3b029d00a7f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f3ad0ee0464842b3ae6ef3b029d00a7f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f3ad0ee0464842b3ae6ef3b029d00a7f"}}, "title": "Vaccination against COVID-19: insight from arterial and venous thrombosis occurrence using data from VigiBase.", "authors": [{"family": "Smadja", "given": "David M", "initials": "DM"}, {"family": "Yue", "given": "Qun-Ying", "initials": "Q"}, {"family": "Chocron", "given": "Richard", "initials": "R"}, {"family": "Sanchez", "given": "Olivier", "initials": "O"}, {"family": "Lillo-Le Louet", "given": "Agnes", "initials": "A"}], "type": "letter", "published": "2021-04-16", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "issn-l": "0903-1936", "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1183/13993003.00956-2021", "pmid": "33863748", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "13993003.00956-2021"}], "notes": [], "created": "2021-04-19T10:39:09.176Z", "modified": "2021-04-29T16:33:21.674Z"}, {"entity": "publication", "iuid": "066372348ae8499fa8e4633f559b0634", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/066372348ae8499fa8e4633f559b0634.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/066372348ae8499fa8e4633f559b0634"}}, "title": "Continuous renal replacement therapy in intensive care patients with COVID-19; survival and renal recovery.", "authors": [{"family": "Eriksson", "given": "Karin E", "initials": "KE"}, {"family": "Campoccia-Jalde", "given": "Francesca", "initials": "F"}, {"family": "Rysz", "given": "Susanne", "initials": "S"}, {"family": "Rimes-Stigare", "given": "Claire", "initials": "C"}], "type": "journal article", "published": "2021-04-16", "journal": {"title": "J Crit Care", "issn": "1557-8615", "volume": "64", "issue": null, "pages": "125-130", "issn-l": "0883-9441"}, "abstract": "Outcome for critically ill patients with COVID-19 treated with continuous renal replacement therapy (CRRT) is largely unknown. We describe mortality and renal outcome in this group.\n\nThis observational study was conducted at a university hospital in Sweden. We studied critically ill adult COVID-19 patients with Acute Kidney injury (AKI) who received CRRT.\n\nIn 451 patients, AKI incidence was 43.7%. 18.2% received CRRT. Median age of CRRT patients was 60 years (IQR 54-65), 90% were male, median BMI was 29 (IQR 25-32), 23.2% had Diabetes, 37.8% hypertension and 6.1% chronic kidney disease prior to admission. 100% required mechanical ventilation. 8.5% received Extra Corporeal Membrane Oxygenation. Median length of stay was 23 days (IQR 15-26). ICU mortality was 39% and 90-day mortality was 45.1%. Age, baseline creatinine values and body weight change were associated with 60 days mortality. Of the survivors, no patients required dialysis at hospital discharge, 73.8% recovered renal function and a median 10.5% of body weight was lost during admission.\n\nCritically ill COVID-19 patients with AKI who received CRRT had a 90-day mortality of 45.1%. At follow-up, three quarters of survivors had recovered renal function. This information is important in the clinical management of COVID-19.", "doi": "10.1016/j.jcrc.2021.04.002", "pmid": "33878517", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0883-9441(21)00063-0"}, {"db": "pmc", "key": "PMC8052481"}], "notes": [], "created": "2021-04-23T04:40:30.388Z", "modified": "2021-04-23T04:40:30.399Z"}, {"entity": "publication", "iuid": "043e3c05fce449a0986615c8f2b88cd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/043e3c05fce449a0986615c8f2b88cd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/043e3c05fce449a0986615c8f2b88cd0"}}, "title": "Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials.", "authors": [{"family": "Axfors", "given": "Cathrine", "initials": "C"}, {"family": "Schmitt", "given": "Andreas M", "initials": "AM", "orcid": "0000-0002-9568-8164", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e04ff63fee604c08bb913012e4645bf6.json"}}, {"family": "Janiaud", "given": "Perrine", "initials": "P"}, {"family": "Van't Hooft", "given": "Janneke", "initials": "J", "orcid": "0000-0001-5303-1503", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4d0cd2d5d4ae4c88bf5b3307e32869a8.json"}}, {"family": "Abd-Elsalam", "given": "Sherief", "initials": "S", "orcid": "0000-0003-4366-2218", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3fb051b677594bbca20b5637fc0420a9.json"}}, {"family": "Abdo", "given": "Ehab F", "initials": "EF", "orcid": "0000-0002-9805-3850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/04cb35857c4b46829ebb73f25fad291a.json"}}, {"family": "Abella", "given": "Benjamin S", "initials": "BS", "orcid": "0000-0003-2521-0891", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7572ea9966aa4951afd5d2490960148e.json"}}, {"family": "Akram", "given": "Javed", "initials": "J"}, {"family": "Amaravadi", "given": "Ravi K", "initials": "RK"}, {"family": "Angus", "given": "Derek C", "initials": "DC"}, {"family": "Arabi", "given": "Yaseen M", "initials": "YM"}, {"family": "Azhar", "given": "Shehnoor", "initials": "S"}, {"family": "Baden", "given": "Lindsey R", "initials": "LR"}, {"family": "Baker", "given": "Arthur W", "initials": "AW", "orcid": "0000-0002-0914-0291", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/51dd5ed5fb784143955e3c7e587b7014.json"}}, {"family": "Belkhir", "given": "Leila", "initials": "L"}, {"family": "Benfield", "given": "Thomas", "initials": "T", "orcid": "0000-0003-0698-9385", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a335d1a321c46b2a0ba4f80dc3d93b4.json"}}, {"family": "Berrevoets", "given": "Marvin A H", "initials": "MAH"}, {"family": "Chen", "given": "Cheng-Pin", "initials": "CP", "orcid": "0000-0002-0629-9790", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/773f850e035a47269048204713babe5f.json"}}, {"family": "Chen", "given": "Tsung-Chia", "initials": "TC", "orcid": "0000-0002-3461-5535", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2df09990f13243b6a7d586e65808f9a5.json"}}, {"family": "Cheng", "given": "Shu-Hsing", "initials": "SH", "orcid": "0000-0002-6256-0527", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/44efc129a6a54e9a85422a2c1122c047.json"}}, {"family": "Cheng", "given": "Chien-Yu", "initials": "CY"}, {"family": "Chung", "given": "Wei-Sheng", "initials": "WS", "orcid": "0000-0003-4240-5690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79973df7d6b94b529a779c7b3d1bc471.json"}}, {"family": "Cohen", "given": "Yehuda Z", "initials": "YZ", "orcid": "0000-0001-6987-1478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f3839874cc0f4a91a69d0fb2fc15c35a.json"}}, {"family": "Cowan", "given": "Lisa N", "initials": "LN"}, {"family": "Dalgard", "given": "Olav", "initials": "O"}, {"family": "de Almeida E Val", "given": "Fernando F", "initials": "FF"}, {"family": "de Lacerda", "given": "Marcus V G", "initials": "MVG", "orcid": "0000-0003-3374-9985", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5df56fcaab5d4fbea3ee4a973b3ed44f.json"}}, {"family": "de Melo", "given": "Gisely C", "initials": "GC"}, {"family": "Derde", "given": "Lennie", "initials": "L", "orcid": "0000-0002-3577-5629", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cdd814a355e486a88cb134b060427bc.json"}}, {"family": "Dubee", "given": "Vincent", "initials": "V", "orcid": "0000-0002-9982-4741", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b4de07c4b894618b95fc8df7917ca03.json"}}, {"family": "Elfakir", "given": "Anissa", "initials": "A"}, {"family": "Gordon", "given": "Anthony C", "initials": "AC", "orcid": "0000-0002-0419-547X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/85b43173291c4fb8b83df85d5dfb3486.json"}}, {"family": "Hernandez-Cardenas", "given": "Carmen M", "initials": "CM", "orcid": "0000-0002-0311-2978", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0aa3c0ab8d3b4da0a63a8d81a5c7d798.json"}}, {"family": "Hills", "given": "Thomas", "initials": "T", "orcid": "0000-0003-0322-5822", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf854b51c68b4b3fb3edee63faa3dfff.json"}}, {"family": "Hoepelman", "given": "Andy I M", "initials": "AIM"}, {"family": "Huang", "given": "Yi-Wen", "initials": "YW"}, {"family": "Igau", "given": "Bruno", "initials": "B"}, {"family": "Jin", "given": "Ronghua", "initials": "R"}, {"family": "Jurado-Camacho", "given": "Felipe", "initials": "F"}, {"family": "Khan", "given": "Khalid S", "initials": "KS"}, {"family": "Kremsner", "given": "Peter G", "initials": "PG"}, {"family": "Kreuels", "given": "Benno", "initials": "B", "orcid": "0000-0003-2315-8954", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/752c98a06cbb43f9b5b8bf63127dd654.json"}}, {"family": "Kuo", "given": "Cheng-Yu", "initials": "CY"}, {"family": "Le", "given": "Thuy", "initials": "T", "orcid": "0000-0002-3393-6580", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2380b23c0d1f423aa831d72279980706.json"}}, {"family": "Lin", "given": "Yi-Chun", "initials": "YC"}, {"family": "Lin", "given": "Wu-Pu", "initials": "WP", "orcid": "0000-0002-4206-7882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86d19e5169de4a139c6508eb7bd1e085.json"}}, {"family": "Lin", "given": "Tse-Hung", "initials": "TH"}, {"family": "Lyngbakken", "given": "Magnus Nakrem", "initials": "MN", "orcid": "0000-0002-5994-9304", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/70c443e4d3674615bf090ed3b0d39e98.json"}}, {"family": "McArthur", "given": "Colin", "initials": "C"}, {"family": "McVerry", "given": "Bryan J", "initials": "BJ", "orcid": "0000-0002-1175-4874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/941d8c555b224fb18d897e9201d42f35.json"}}, {"family": "Meza-Meneses", "given": "Patricia", "initials": "P", "orcid": "0000-0002-3931-3114", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be8220f4a58244838e2252f67c3ea28b.json"}}, {"family": "Monteiro", "given": "Wuelton M", "initials": "WM"}, {"family": "Morpeth", "given": "Susan C", "initials": "SC"}, {"family": "Mourad", "given": "Ahmad", "initials": "A", "orcid": "0000-0002-3149-597X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3323fc32cf4e44b2b677b838954f86aa.json"}}, {"family": "Mulligan", "given": "Mark J", "initials": "MJ"}, {"family": "Murthy", "given": "Srinivas", "initials": "S"}, {"family": "Naggie", "given": "Susanna", "initials": "S"}, {"family": "Narayanasamy", "given": "Shanti", "initials": "S", "orcid": "0000-0002-6667-2868", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/53cc5ca9db8d49678370dbaad3d91ac0.json"}}, {"family": "Nichol", "given": "Alistair", "initials": "A"}, {"family": "Novack", "given": "Lewis A", "initials": "LA"}, {"family": "O'Brien", "given": "Sean M", "initials": "SM"}, {"family": "Okeke", "given": "Nwora Lance", "initials": "NL"}, {"family": "Perez", "given": "L\u00e9na", "initials": "L"}, {"family": "Perez-Padilla", "given": "Rogelio", "initials": "R"}, {"family": "Perrin", "given": "Laurent", "initials": "L", "orcid": "0000-0002-1916-6639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1bdac388f14a404aa6a02e69083181fb.json"}}, {"family": "Remigio-Luna", "given": "Arantxa", "initials": "A"}, {"family": "Rivera-Martinez", "given": "Norma E", "initials": "NE", "orcid": "0000-0002-6716-1234", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a0214c04c5d94f0082f9068398ab6e37.json"}}, {"family": "Rockhold", "given": "Frank W", "initials": "FW", "orcid": "0000-0003-3732-4765", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/409f57f9cdcd46f7bac6c309f50f6673.json"}}, {"family": "Rodriguez-Llamazares", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-7864-8953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76eb08936ea3405eb020251713f28c3d.json"}}, {"family": "Rolfe", "given": "Robert", "initials": "R"}, {"family": "Rosa", "given": "Rossana", "initials": "R"}, {"family": "R\u00f8sj\u00f8", "given": "Helge", "initials": "H"}, {"family": "Sampaio", "given": "Vanderson S", "initials": "VS", "orcid": "0000-0001-7307-8851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/934ee588c764416998481a7dbe4aad3e.json"}}, {"family": "Seto", "given": "Todd B", "initials": "TB"}, {"family": "Shahzad", "given": "Muhammad", "initials": "M"}, {"family": "Soliman", "given": "Shaimaa", "initials": "S"}, {"family": "Stout", "given": "Jason E", "initials": "JE", "orcid": "0000-0002-6698-8176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45ca2262503a439db34471f94f65aa11.json"}}, {"family": "Thirion-Romero", "given": "Ireri", "initials": "I"}, {"family": "Troxel", "given": "Andrea B", "initials": "AB"}, {"family": "Tseng", "given": "Ting-Yu", "initials": "TY"}, {"family": "Turner", "given": "Nicholas A", "initials": "NA", "orcid": "0000-0003-0650-4894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7aa17d22034b4cc4aca4c38f6323c099.json"}}, {"family": "Ulrich", "given": "Robert J", "initials": "RJ", "orcid": "0000-0002-3217-5062", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d560647d4cd74ecaa958445933fef02d.json"}}, {"family": "Walsh", "given": "Stephen R", "initials": "SR", "orcid": "0000-0002-0817-9370", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5569d26075364c7294b1d49d084d27bf.json"}}, {"family": "Webb", "given": "Steve A", "initials": "SA"}, {"family": "Weehuizen", "given": "Jesper M", "initials": "JM"}, {"family": "Velinova", "given": "Maria", "initials": "M"}, {"family": "Wong", "given": "Hon-Lai", "initials": "HL"}, {"family": "Wrenn", "given": "Rebekah", "initials": "R"}, {"family": "Zampieri", "given": "Fernando G", "initials": "FG", "orcid": "0000-0001-9315-6386", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6d3264c064a4675bdbde7937711265c.json"}}, {"family": "Zhong", "given": "Wu", "initials": "W", "orcid": "0000-0002-0536-620X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8058cd239379403195b1cd7d9b5ca689.json"}}, {"family": "Moher", "given": "David", "initials": "D", "orcid": "0000-0003-2434-4206", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/765e99136e2943c7a7f4ce4ed5848ff9.json"}}, {"family": "Goodman", "given": "Steven N", "initials": "SN"}, {"family": "Ioannidis", "given": "John P A", "initials": "JPA", "orcid": "0000-0003-3118-6859", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9844ea41bc554157a721820d7986a442.json"}}, {"family": "Hemkens", "given": "Lars G", "initials": "LG", "orcid": "0000-0002-3444-1432", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4b2562d656a74e7d91427b55ca667784.json"}}], "type": "journal article", "published": "2021-04-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "2349"}, "abstract": "Substantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or early discontinuation. We aim to estimate the effects of hydroxychloroquine and chloroquine on survival in COVID-19 from all currently available RCT evidence, published and unpublished. We present a rapid meta-analysis of ongoing, completed, or discontinued RCTs on hydroxychloroquine or chloroquine treatment for any COVID-19 patients (protocol: https://osf.io/QESV4/ ). We systematically identified unpublished RCTs (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, Cochrane COVID-registry up to June 11, 2020), and published RCTs (PubMed, medRxiv and bioRxiv up to October 16, 2020). All-cause mortality has been extracted (publications/preprints) or requested from investigators and combined in random-effects meta-analyses, calculating odds ratios (ORs) with 95% confidence intervals (CIs), separately for hydroxychloroquine and chloroquine. Prespecified subgroup analyses include patient setting, diagnostic confirmation, control type, and publication status. Sixty-three trials were potentially eligible. We included 14 unpublished trials (1308 patients) and 14 publications/preprints (9011 patients). Results for hydroxychloroquine are dominated by RECOVERY and WHO SOLIDARITY, two highly pragmatic trials, which employed relatively high doses and included 4716 and 1853 patients, respectively (67% of the total sample size). The combined OR on all-cause mortality for hydroxychloroquine is 1.11 (95% CI: 1.02, 1.20; I\u00b2 = 0%; 26 trials; 10,012 patients) and for chloroquine 1.77 (95%CI: 0.15, 21.13, I\u00b2 = 0%; 4 trials; 307 patients). We identified no subgroup effects. We found that treatment with hydroxychloroquine is associated with increased mortality in COVID-19 patients, and there is no benefit of chloroquine. Findings have unclear generalizability to outpatients, children, pregnant women, and people with comorbidities.", "doi": "10.1038/s41467-021-22446-z", "pmid": "33859192", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC8050319"}, {"db": "pii", "key": "10.1038/s41467-021-22446-z"}], "notes": [], "created": "2021-04-19T09:55:46.003Z", "modified": "2023-06-19T15:39:29.947Z"}, {"entity": "publication", "iuid": "6962a2e2313a498f92cb46da8b7054c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6962a2e2313a498f92cb46da8b7054c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6962a2e2313a498f92cb46da8b7054c9"}}, "title": "Impaired diffusing capacity for carbon monoxide is common in critically ill Covid-19 patients at four months post-discharge.", "authors": [{"family": "Ekbom", "given": "E", "initials": "E"}, {"family": "Frithiof", "given": "R", "initials": "R"}, {"family": "Emilsson", "given": "\u00d6", "initials": "\u00d6"}, {"family": "Larson", "given": "IM", "initials": "I"}, {"family": "Lipcsey", "given": "M", "initials": "M"}, {"family": "Rubertsson", "given": "S", "initials": "S"}, {"family": "Wallin", "given": "E", "initials": "E"}, {"family": "Janson", "given": "C", "initials": "C"}, {"family": "Hultstr\u00f6m", "given": ", M", "initials": ",M"}, {"family": "Malinovschi", "given": ", A", "initials": ",A"}], "type": "journal article", "published": "2021-04-15", "journal": {"title": "Respir Med", "issn": "1532-3064", "issn-l": "0954-6111", "volume": "182", "issue": null, "pages": "106394"}, "abstract": "There is limited knowledge about the long-term effects on pulmonary function of COVID-19 in patients that required intensive care treatment. Spirometry and diffusing capacity for carbon monoxide (DLCO) were measured in 60 subjects at 3-6 months post discharge. Impaired lung function was found in 52% of the subjects, with reduced DLCO as the main finding. The risk increased with age above 60 years, need for mechanical ventilation and longer ICU stay as well as lower levels of C-reactive protein at admission. This suggests the need of follow-up with pulmonary function testing in intensive-care treated patients.", "doi": "10.1016/j.rmed.2021.106394", "pmid": "33901787", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pii", "key": "S0954-6111(21)00100-1"}], "notes": [], "created": "2021-04-29T10:24:46.257Z", "modified": "2021-06-11T14:13:00.138Z"}, {"entity": "publication", "iuid": "a78e8cfff07a42a39fd12fc31fd02007", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a78e8cfff07a42a39fd12fc31fd02007.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a78e8cfff07a42a39fd12fc31fd02007"}}, "title": "Impacts of COVID-19 on sick leave", "authors": [{"family": "Skyrud", "given": "Katrine", "initials": "K"}, {"family": "Telle", "given": "Kjetil", "initials": "K"}, {"family": "Hern\u00e6s", "given": "Kjersti", "initials": "K"}, {"family": "Magnusson", "given": "Karin", "initials": "K"}], "type": "posted-content", "published": "2021-04-15", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.09.21255215", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-14T06:41:17.696Z", "modified": "2021-06-18T09:28:15.257Z"}, {"entity": "publication", "iuid": "2813f0500ac641f09c8b641b69e12be7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2813f0500ac641f09c8b641b69e12be7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2813f0500ac641f09c8b641b69e12be7"}}, "title": "Immune Profile in Patients With COVID-19: Lymphocytes Exhaustion Markers in Relationship to Clinical Outcome.", "authors": [{"family": "Bobcakova", "given": "Anna", "initials": "A"}, {"family": "Petriskova", "given": "Jela", "initials": "J"}, {"family": "Vysehradsky", "given": "Robert", "initials": "R"}, {"family": "Kocan", "given": "Ivan", "initials": "I"}, {"family": "Kapustova", "given": "Lenka", "initials": "L"}, {"family": "Barnova", "given": "Martina", "initials": "M"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}, {"family": "Jesenak", "given": "Milos", "initials": "M"}], "type": "journal article", "published": "2021-04-15", "journal": {"title": "Front Cell Infect Microbiol", "issn": "2235-2988", "volume": "11", "issue": null, "pages": "646688", "issn-l": null}, "abstract": "The velocity of the COVID-19 pandemic spread and the variable severity of the disease course has forced scientists to search for potential predictors of the disease outcome. We examined various immune parameters including the markers of immune cells exhaustion and activation in 21 patients with COVID-19 disease hospitalised in our hospital during the first wave of the COVID-19 pandemic in Slovakia. The results showed significant progressive lymphopenia and depletion of lymphocyte subsets (CD3 +, CD4+, CD8+ and CD19+) in correlation to the disease severity. Clinical recovery was associated with significant increase in CD3+ and CD3+CD4+ T-cells. Most of our patients had eosinopenia on admission, although no significant differences were seen among groups with different disease severity. Non-survivors, when compared to survivors, had significantly increased expression of PD-1 on CD4+ and CD8+ cells, but no significant difference in Tim-3 expression was observed, what suggests possible reversibility of immune paralysis in the most severe group of patients. During recovery, the expression of Tim-3 on both CD3+CD4+ and CD3+CD8+ cells significantly decreased. Moreover, patients with fatal outcome had significantly higher proportion of CD38+CD8+ cells and lower proportion of CD38+HLA-DR+CD8+ cells on admission. Clinical recovery was associated with significant decrease of proportion of CD38+CD8+ cells. The highest AUC values within univariate and multivariate logistic regression were achieved for expression of CD38 on CD8+ cells and expression of PD1 on CD4+ cells alone or combined, what suggests, that these parameters could be used as potential biomarkers of poor outcome. The assessment of immune markers could help in predicting outcome and disease severity in COVID-19 patients. Our observations suggest, that apart from the degree of depletion of total lymphocytes and lymphocytes subsets, increased expression of CD38 on CD3+CD8+ cells alone or combined with increased expression of PD-1 on CD3+CD4+ cells, should be regarded as a risk factor of an unfavourable outcome in COVID-19 patients. Increased expression of PD-1 in the absence of an increased expression of Tim-3 on CD3+CD4+ and CD3+CD8+ cells suggests potential reversibility of ongoing immune paralysis in patients with the most severe course of COVID-19.", "doi": "10.3389/fcimb.2021.646688", "pmid": "33937096", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8082075"}], "notes": [], "created": "2021-05-04T15:59:00.820Z", "modified": "2021-05-04T15:59:29.077Z"}, {"entity": "publication", "iuid": "59f5bb4de6904a3c86e0194414dec772", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/59f5bb4de6904a3c86e0194414dec772.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/59f5bb4de6904a3c86e0194414dec772"}}, "title": "Appropriateness for SARS-CoV-2 vaccination for otolaryngologist and head and neck surgeons in case of pregnancy, breastfeeding, or childbearing potential: Yo-IFOS and CEORL-HNS joint clinical consensus statement.", "authors": [{"family": "Saibene", "given": "Alberto Maria", "initials": "AM"}, {"family": "Allevi", "given": "Fabiana", "initials": "F"}, {"family": "Ayad", "given": "Tareck", "initials": "T"}, {"family": "Baudoin", "given": "Tomislav", "initials": "T"}, {"family": "Bernal-Sprekelsen", "given": "Manuel", "initials": "M"}, {"family": "Briganti", "given": "Giovanni", "initials": "G"}, {"family": "Carrie", "given": "Sean", "initials": "S"}, {"family": "Cay\u00e9-Thomasen", "given": "Per", "initials": "P"}, {"family": "Dahman Saidi", "given": "Sara", "initials": "S"}, {"family": "Dauby", "given": "Nicolas", "initials": "N"}, {"family": "Fenton", "given": "John", "initials": "J"}, {"family": "Golusi\u0144ski", "given": "Wojciech", "initials": "W"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Leclerc", "given": "Andr\u00e9e-Anne", "initials": "A"}, {"family": "Longtin", "given": "Yves", "initials": "Y"}, {"family": "Mannelli", "given": "Giuditta", "initials": "G"}, {"family": "Mayo-Y\u00e1\u00f1ez", "given": "Miguel", "initials": "M"}, {"family": "Me\u00e7o", "given": "Cem", "initials": "C"}, {"family": "Metwaly", "given": "Osama", "initials": "O"}, {"family": "Mouawad", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Niemczyk", "given": "Kazimierz", "initials": "K"}, {"family": "Pedersen", "given": "Ulrik", "initials": "U"}, {"family": "Piersiala", "given": "Krzysztof", "initials": "K"}, {"family": "Plzak", "given": "Jan", "initials": "J"}, {"family": "Remacle", "given": "Marc", "initials": "M"}, {"family": "Rommel", "given": "Nathalie", "initials": "N"}, {"family": "Saleh", "given": "Hesham", "initials": "H"}, {"family": "Szpecht", "given": "Dawid", "initials": "D"}, {"family": "Tedla", "given": "Miroslav", "initials": "M"}, {"family": "Tincati", "given": "Camilla", "initials": "C"}, {"family": "Tucciarone", "given": "Manuel", "initials": "M"}, {"family": "Zelenik", "given": "Karol", "initials": "K"}, {"family": "Lechien", "given": "Jerome R", "initials": "JR"}], "type": "journal article", "published": "2021-04-15", "journal": {"title": "Eur Arch Otorhinolaryngol", "issn": "1434-4726", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "SARS-CoV-2 vaccines are a key step in fighting the pandemic. Nevertheless, their rapid development did not allow for testing among specific population subgroups such as pregnant and breastfeeding women, or elaborating specific guidelines for healthcare personnel working in high infection risk specialties, such as otolaryngology (ORL). This clinical consensus statement (CCS) aims to offer guidance for SARS-CoV-2 vaccination to this high-risk population based on the best evidence available.\r\n\r\nA multidisciplinary international panel of 33 specialists judged statements through a two-round modified Delphi method survey. Statements were designed to encompass the following topics: risk of SARS-Cov-2 infection and use of protective equipment in ORL; SARS-Cov-2 infection and vaccines and respective risks for the mother/child dyad; and counseling for SARS-CoV-2 vaccination in pregnant, breastfeeding, or fertile healthcare workers (PBFHW). All ORL PBFHW were considered as the target audience.\r\n\r\nOf the 13 statements, 7 reached consensus or strong consensus, 2 reached no consensus, and 2 reached near-consensus. According to the statements with strong consensus otorhinolaryngologists-head and neck surgeons who are pregnant, breastfeeding, or with childbearing potential should have the opportunity to receive SARS-Cov-2 vaccination. Moreover, personal protective equipment (PPE) should still be used even after the vaccination.\r\n\r\nUntil prospective evaluations on these topics are available, ORL-HNS must be considered a high infection risk specialty. While the use of PPE remains pivotal, ORL PBFHW should be allowed access to SARS-CoV-2 vaccination provided they receive up-to-date information.", "doi": "10.1007/s00405-021-06794-6", "pmid": "33855628", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00405-021-06794-6"}, {"db": "pmc", "key": "PMC8046580"}], "notes": [], "created": "2021-04-19T09:53:24.711Z", "modified": "2021-04-19T09:53:40.064Z"}, {"entity": "publication", "iuid": "ad1e20fc179f437b8ca521f323d4b8ea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ad1e20fc179f437b8ca521f323d4b8ea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ad1e20fc179f437b8ca521f323d4b8ea"}}, "title": "A distinct metabolic profile associated with a fatal outcome in COVID-19 patients during early epidemic in Italy", "authors": [{"family": "Saccon", "given": "Elisa", "initials": "E"}, {"family": "Bandera", "given": "Alessandra", "initials": "A"}, {"family": "Scium\u00e8", "given": "Mariarita", "initials": "M"}, {"family": "Mikeloff", "given": "Flora", "initials": "F"}, {"family": "Lashari", "given": "Abid Ali", "initials": "AA"}, {"family": "Aliberti", "given": "Stefano", "initials": "S"}, {"family": "Sachs", "given": "Michael", "initials": "M"}, {"family": "Billi", "given": "Filippo", "initials": "F"}, {"family": "Blasi", "given": "Francesco", "initials": "F"}, {"family": "Gabriel", "given": "Erin", "initials": "E"}, {"family": "Costantino", "given": "Giorgio", "initials": "G"}, {"family": "De Roberto", "given": "Pasquale", "initials": "P"}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Gori", "given": "Andrea", "initials": "A"}, {"family": "Peyvandi", "given": "Flora", "initials": "F"}, {"family": "Scudeller", "given": "Luigia", "initials": "L"}, {"family": "Lorson", "given": "Christian L", "initials": "CL"}, {"family": "Valenti", "given": "Luca", "initials": "L"}, {"family": "Singh", "given": "Kamal", "initials": "K"}, {"family": "Baldini", "given": "Luca", "initials": "L"}, {"family": "Fracchiolla", "given": "Nicola Stefano", "initials": "NS"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "posted-content", "published": "2021-04-15", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.13.21255117", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-29T16:43:34.352Z", "modified": "2021-06-04T14:21:33.699Z"}, {"entity": "publication", "iuid": "3f9371406eef47b4b4cb3d96d22bf226", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f9371406eef47b4b4cb3d96d22bf226.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f9371406eef47b4b4cb3d96d22bf226"}}, "title": "Coronavirus Disease 19 from the Perspective of Ageing with Focus on Nutritional Status and Nutrition Management-A Narrative Review.", "authors": [{"family": "Rothenberg", "given": "Elisabet", "initials": "E"}], "type": "journal article", "published": "2021-04-14", "journal": {"title": "Nutrients", "issn": "2072-6643", "volume": "13", "issue": "4", "issn-l": null}, "abstract": "The novel severe acute respiratory syndrome coronavirus (COVID-19) has hit older adults harder due to a combination of age-related immunological and metabolic alterations. The aim of this review was to analyze the COVID-19 literature with respect to nutritional status and nutrition management in older adults. No studies only on people aged 65+ years were found, and documentation on those 80+ was rare. Age was found to be strongly associated with worse outcomes, and with poor nutritional status. Prevalence of malnutrition was high among severely and critically ill patients. The studies found a need for nutrition screening and management, and for nutrition support as part of follow-up after a hospital stay. Most tested screening tools showed high sensitivity in identifying nutritional risk, but none were recognized as best for screening older adults with COVID-19. For diagnosing malnutrition, the Global Leadership Initiative on Malnutrition (GLIM) criteria are recommended but were not used in the studies found. Documentation of olfactory and gustatory dysfunction in relation to nutritional status is missing in older adults. Other COVID-19-associated factors with a possible impact on nutritional status are poor appetite and gastrointestinal symptoms. Vitamin D is the nutrient that has attracted the most interest. However, evidence for supplementation of COVID-19 patients is still limited and inconclusive.", "doi": "10.3390/nu13041294", "pmid": "33919840", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "nu13041294"}, {"db": "pmc", "key": "PMC8070771"}], "notes": [], "created": "2021-05-04T16:25:12.442Z", "modified": "2021-05-04T16:25:46.758Z"}, {"entity": "publication", "iuid": "f754dc7c44e04bf2ae96d4f2bf59913c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f754dc7c44e04bf2ae96d4f2bf59913c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f754dc7c44e04bf2ae96d4f2bf59913c"}}, "title": "Visual scoring of chest CT at hospital admission predicts hospitalization time and intensive care admission in Covid-19.", "authors": [{"family": "Ahlstrand", "given": "Erik", "initials": "E"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "Cajander", "given": "Per", "initials": "P"}, {"family": "Ingberg", "given": "Edvin", "initials": "E"}, {"family": "L\u00f6f", "given": "Erika", "initials": "E"}, {"family": "Wegener", "given": "Matthias", "initials": "M"}, {"family": "Lid\u00e9n", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2021-04-13", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": null, "issue": null, "pages": "1-11"}, "abstract": "Chest CT is prognostic in Covid-19 but there is a lack of consensus on how to report the CT findings. A chest CT scoring system, \u00d6CoS, was implemented in clinical routine on 1 April 2020, in \u00d6rebro Region, Sweden. The \u00d6CoS-severity score measures the extent of lung involvement. The objective of the study was to evaluate the \u00d6CoS scores as predictors of the clinical course of Covid-19.\r\n\r\nPopulation based study including data from all hospitalized patients with Covid-19 in \u00d6rebro Region during March to July 2020. We evaluated the correlations between CT scores at the time of admission to hospital and intensive care in relation to hospital and intensive care length of stay (LoS), intensive care admission and death. C-reactive protein and lymphocyte count were included as covariates in multivariate regression analyses.\r\n\r\nIn 381 included patients, the \u00d6CoS-severity score at admission closely correlated to hospital length of stay, and intensive care admission or death. At admission to intensive care, the \u00d6CoS-severity score correlated with intensive care length of stay. The \u00d6CoS-severity score was superior to basic inflammatory biomarkers in predicting clinical outcomes.\r\n\r\nChest CT visual scoring at admission to hospital predicted the clinical course of Covid-19 pneumonia.", "doi": "10.1080/23744235.2021.1910727", "pmid": "33848219", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-14T14:27:47.477Z", "modified": "2021-04-14T14:27:58.253Z"}, {"entity": "publication", "iuid": "089b4032333d45b9ae32c98f22312369", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/089b4032333d45b9ae32c98f22312369.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/089b4032333d45b9ae32c98f22312369"}}, "title": "Suicide trends in the early months of the COVID-19 pandemic: an interrupted time-series analysis of preliminary data from 21 countries.", "authors": [{"family": "Pirkis", "given": "Jane", "initials": "J"}, {"family": "John", "given": "Ann", "initials": "A"}, {"family": "Shin", "given": "Sangsoo", "initials": "S"}, {"family": "DelPozo-Banos", "given": "Marcos", "initials": "M"}, {"family": "Arya", "given": "Vikas", "initials": "V"}, {"family": "Analuisa-Aguilar", "given": "Pablo", "initials": "P"}, {"family": "Appleby", "given": "Louis", "initials": "L"}, {"family": "Arensman", "given": "Ella", "initials": "E"}, {"family": "Bantjes", "given": "Jason", "initials": "J"}, {"family": "Baran", "given": "Anna", "initials": "A"}, {"family": "Bertolote", "given": "Jose M", "initials": "JM"}, {"family": "Borges", "given": "Guilherme", "initials": "G"}, {"family": "Bre\u010di\u0107", "given": "Petrana", "initials": "P"}, {"family": "Caine", "given": "Eric", "initials": "E"}, {"family": "Castelpietra", "given": "Giulio", "initials": "G"}, {"family": "Chang", "given": "Shu-Sen", "initials": "S"}, {"family": "Colchester", "given": "David", "initials": "D"}, {"family": "Crompton", "given": "David", "initials": "D"}, {"family": "Curkovic", "given": "Marko", "initials": "M"}, {"family": "Deisenhammer", "given": "Eberhard A", "initials": "EA"}, {"family": "Du", "given": "Chengan", "initials": "C"}, {"family": "Dwyer", "given": "Jeremy", "initials": "J"}, {"family": "Erlangsen", "given": "Annette", "initials": "A"}, {"family": "Faust", "given": "Jeremy S", "initials": "JS"}, {"family": "Fortune", "given": "Sarah", "initials": "S"}, {"family": "Garrett", "given": "Andrew", "initials": "A"}, {"family": "George", "given": "Devin", "initials": "D"}, {"family": "Gerstner", "given": "Rebekka", "initials": "R"}, {"family": "Gilissen", "given": "Renske", "initials": "R"}, {"family": "Gould", "given": "Madelyn", "initials": "M"}, {"family": "Hawton", "given": "Keith", "initials": "K"}, {"family": "Kanter", "given": "Joseph", "initials": "J"}, {"family": "Kapur", "given": "Navneet", "initials": "N"}, {"family": "Khan", "given": "Murad", "initials": "M"}, {"family": "Kirtley", "given": "Olivia J", "initials": "OJ"}, {"family": "Knipe", "given": "Duleeka", "initials": "D"}, {"family": "Kolves", "given": "Kairi", "initials": "K"}, {"family": "Leske", "given": "Stuart", "initials": "S"}, {"family": "Marahatta", "given": "Kedar", "initials": "K"}, {"family": "Mittendorfer-Rutz", "given": "Ellenor", "initials": "E"}, {"family": "Neznanov", "given": "Nikolay", "initials": "N"}, {"family": "Niederkrotenthaler", "given": "Thomas", "initials": "T"}, {"family": "Nielsen", "given": "Emma", "initials": "E"}, {"family": "Nordentoft", "given": "Merete", "initials": "M"}, {"family": "Oberlerchner", "given": "Herwig", "initials": "H"}, {"family": "O'Connor", "given": "Rory C", "initials": "RC"}, {"family": "Pearson", "given": "Melissa", "initials": "M"}, {"family": "Phillips", "given": "Michael R", "initials": "MR"}, {"family": "Platt", "given": "Steve", "initials": "S"}, {"family": "Plener", "given": "Paul L", "initials": "PL"}, {"family": "Psota", "given": "Georg", "initials": "G"}, {"family": "Qin", "given": "Ping", "initials": "P"}, {"family": "Radeloff", "given": "Daniel", "initials": "D"}, {"family": "Rados", "given": "Christa", "initials": "C"}, {"family": "Reif", "given": "Andreas", "initials": "A"}, {"family": "Reif-Leonhard", "given": "Christine", "initials": "C"}, {"family": "Rozanov", "given": "Vsevolod", "initials": "V"}, {"family": "Schlang", "given": "Christiane", "initials": "C"}, {"family": "Schneider", "given": "Barbara", "initials": "B"}, {"family": "Semenova", "given": "Natalia", "initials": "N"}, {"family": "Sinyor", "given": "Mark", "initials": "M"}, {"family": "Townsend", "given": "Ellen", "initials": "E"}, {"family": "Ueda", "given": "Michiko", "initials": "M"}, {"family": "Vijayakumar", "given": "Lakshmi", "initials": "L"}, {"family": "Webb", "given": "Roger T", "initials": "RT"}, {"family": "Weerasinghe", "given": "Manjula", "initials": "M"}, {"family": "Zalsman", "given": "Gil", "initials": "G"}, {"family": "Gunnell", "given": "David", "initials": "D"}, {"family": "Spittal", "given": "Matthew J", "initials": "MJ"}], "type": "journal article", "published": "2021-04-13", "journal": {"title": "Lancet Psychiatry", "issn": "2215-0374", "issn-l": "2215-0366", "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic is having profound mental health consequences for many people. Concerns have been expressed that, at their most extreme, these consequences could manifest as increased suicide rates. We aimed to assess the early effect of the COVID-19 pandemic on suicide rates around the world.\r\n\r\nWe sourced real-time suicide data from countries or areas within countries through a systematic internet search and recourse to our networks and the published literature. Between Sept 1 and Nov 1, 2020, we searched the official websites of these countries' ministries of health, police agencies, and government-run statistics agencies or equivalents, using the translated search terms \"suicide\" and \"cause of death\", before broadening the search in an attempt to identify data through other public sources. Data were included from a given country or area if they came from an official government source and were available at a monthly level from at least Jan 1, 2019, to July 31, 2020. Our internet searches were restricted to countries with more than 3 million residents for pragmatic reasons, but we relaxed this rule for countries identified through the literature and our networks. Areas within countries could also be included with populations of less than 3 million. We used an interrupted time-series analysis to model the trend in monthly suicides before COVID-19 (from at least Jan 1, 2019, to March 31, 2020) in each country or area within a country, comparing the expected number of suicides derived from the model with the observed number of suicides in the early months of the pandemic (from April 1 to July 31, 2020, in the primary analysis).\r\n\r\nWe sourced data from 21 countries (16 high-income and five upper-middle-income countries), including whole-country data in ten countries and data for various areas in 11 countries). Rate ratios (RRs) and 95% CIs based on the observed versus expected numbers of suicides showed no evidence of a significant increase in risk of suicide since the pandemic began in any country or area. There was statistical evidence of a decrease in suicide compared with the expected number in 12 countries or areas: New South Wales, Australia (RR 0\u00b781 [95% CI 0\u00b772-0\u00b791]); Alberta, Canada (0\u00b780 [0\u00b768-0\u00b793]); British Columbia, Canada (0\u00b776 [0\u00b766-0\u00b787]); Chile (0\u00b785 [0\u00b778-0\u00b794]); Leipzig, Germany (0\u00b749 [0\u00b732-0\u00b774]); Japan (0\u00b794 [0\u00b791-0\u00b796]); New Zealand (0\u00b779 [0\u00b768-0\u00b791]); South Korea (0\u00b794 [0\u00b792-0\u00b797]); California, USA (0\u00b790 [0\u00b785-0\u00b795]); Illinois (Cook County), USA (0\u00b779 [0\u00b767-0\u00b793]); Texas (four counties), USA (0\u00b782 [0\u00b768-0\u00b798]); and Ecuador (0\u00b774 [0\u00b767-0\u00b782]).\r\n\r\nThis is the first study to examine suicides occurring in the context of the COVID-19 pandemic in multiple countries. In high-income and upper-middle-income countries, suicide numbers have remained largely unchanged or declined in the early months of the pandemic compared with the expected levels based on the pre-pandemic period. We need to remain vigilant and be poised to respond if the situation changes as the longer-term mental health and economic effects of the pandemic unfold.\r\n\r\nNone.", "doi": "10.1016/S2215-0366(21)00091-2", "pmid": "33862016", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2215-0366(21)00091-2"}], "notes": [], "created": "2021-04-19T10:38:03.711Z", "modified": "2021-04-19T10:38:33.043Z"}, {"entity": "publication", "iuid": "84cac197afb5412a821b404f0f43a2ce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84cac197afb5412a821b404f0f43a2ce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84cac197afb5412a821b404f0f43a2ce"}}, "title": "Structure, Dynamics, Receptor Binding, and Antibody Binding of the Fully Glycosylated Full-Length SARS-CoV-2 Spike Protein in a Viral Membrane.", "authors": [{"family": "Choi", "given": "Yeol Kyo", "initials": "YK", "orcid": "0000-0002-4218-7139", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2885ea927174b0aabe0ab76d5fba484.json"}}, {"family": "Cao", "given": "Yiwei", "initials": "Y", "orcid": "0000-0002-4516-8689", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15efd17a7c1342a3aa46bab1e2b9e241.json"}}, {"family": "Frank", "given": "Martin", "initials": "M", "orcid": "0000-0002-1006-6746", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee6b5d165615455da3cf49fad65598e9.json"}}, {"family": "Woo", "given": "Hyeonuk", "initials": "H", "orcid": "0000-0002-6495-4087", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2dfd6c1c6f34de2b6b768ce70a67ebb.json"}}, {"family": "Park", "given": "Sang-Jun", "initials": "SJ", "orcid": "0000-0002-7307-3724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dede807702c34573bfe7de0b40c48de9.json"}}, {"family": "Yeom", "given": "Min Sun", "initials": "MS", "orcid": "0000-0001-9977-8768", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7ae6fb73cfb47199fd5e4a468aa5554.json"}}, {"family": "Croll", "given": "Tristan I", "initials": "TI", "orcid": "0000-0002-3514-8377", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a6c1536819d496490962f5f89bebc6f.json"}}, {"family": "Seok", "given": "Chaok", "initials": "C", "orcid": "0000-0002-1419-9888", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a93933221aa54cda9547eb7f063c154c.json"}}, {"family": "Im", "given": "Wonpil", "initials": "W", "orcid": "0000-0001-5642-6041", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9c6b1fc87fa647459c5a112e9fa6b8ce.json"}}], "type": "journal article", "published": "2021-04-13", "journal": {"title": "J Chem Theory Comput", "issn": "1549-9626", "issn-l": null, "volume": "17", "issue": "4", "pages": "2479-2487"}, "abstract": "The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mediates host cell entry by binding to angiotensin-converting enzyme 2 (ACE2) and is considered the major target for drug and vaccine development. We previously built fully glycosylated full-length SARS-CoV-2 S protein models in a viral membrane including both open and closed conformations of the receptor-binding domain (RBD) and different templates for the stalk region. In this work, multiple \u03bcs-long all-atom molecular dynamics simulations were performed to provide deeper insights into the structure and dynamics of S protein and glycan functions. Our simulations reveal that the highly flexible stalk is composed of two independent joints and most probable S protein orientations are competent for ACE2 binding. We identify multiple glycans stabilizing the open and/or closed states of the RBD and demonstrate that the exposure of antibody epitopes can be captured by detailed antibody-glycan clash analysis instead of commonly used accessible surface area analysis that tends to overestimate the impact of glycan shielding and neglect possible detailed interactions between glycan and antibodies. Overall, our observations offer structural and dynamic insights into the SARS-CoV-2 S protein and potentialize for guiding the design of effective antiviral therapeutics.", "doi": "10.1021/acs.jctc.0c01144", "pmid": "33689337", "labels": {"Category: Biochemistry": null, "Type: Journal article": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC8047829"}], "notes": [], "created": "2021-03-12T06:09:38.310Z", "modified": "2023-06-19T14:35:39.264Z"}, {"entity": "publication", "iuid": "cf393d99432444dea582e4df887afe07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cf393d99432444dea582e4df887afe07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cf393d99432444dea582e4df887afe07"}}, "title": "Motivation to Have COVID-19 Vaccination Explained Using an Extended Protection Motivation Theory among University Students in China: The Role of Information Sources.", "authors": [{"family": "Wang", "given": "Peng-Wei", "initials": "P"}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Chen", "given": "I-Hua", "initials": "I"}, {"family": "Yen", "given": "Cheng-Fang", "initials": "C"}, {"family": "Kuo", "given": "Yi-Jie", "initials": "Y"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-04-13", "journal": {"title": "Vaccines", "issn": "2076-393X", "issn-l": null, "volume": "9", "issue": "4", "pages": null}, "abstract": "The aims of the present study were to examine the prediction of the threat and coping appraisal utilizing an extended protection motivation theory (PMT) for the motivation to have COVID-19 vaccination and the influence of various information sources on coping appraisal among university students in China.\r\n\r\nThe sample comprised 3145 students from 43 universities in China who completed an online survey including PMT constructs as well as constructs added to PMT. The PMT constructs comprised motivation to have COVID-19 vaccination, threat appraisal, and coping appraisal. The extended PMT constructs comprised knowledge about mechanisms and information sources of COVID-19 vaccination.\r\n\r\nPerceived severity of COVID-19 was positively associated with motivation to have COVID-19 vaccination. Receiving information concerning COVID-19 vaccination from medical personnel was associated with greater self-efficacy, response efficacy, and knowledge, whereas receiving information concerning COVID-19 vaccination from coworkers/colleagues was associated with less response efficacy and knowledge. Receiving online information concerning COVID-19 vaccination was associated with greater response cost of vaccination efficacy and less knowledge.\r\n\r\nThis study supported the prediction of perceived severity in the PMT for motivation to have COVID-19 vaccination among university students in China. Vaccination information sources have different effects on students' coping appraisal of COVID-19 vaccination.", "doi": "10.3390/vaccines9040380", "pmid": "33924604", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "vaccines9040380"}, {"db": "pmc", "key": "PMC8070343"}], "notes": [], "created": "2021-05-04T16:22:30.374Z", "modified": "2021-07-14T07:14:10.905Z"}, {"entity": "publication", "iuid": "754c69dd322a4156bbbbb6d9131ce4ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/754c69dd322a4156bbbbb6d9131ce4ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/754c69dd322a4156bbbbb6d9131ce4ff"}}, "title": "GRAd-COV2, a gorilla adenovirus based candidate vaccine against COVID-19, is safe and immunogenic in young and older adults", "authors": [{"family": "Lanini", "given": "Simone", "initials": "S"}, {"family": "Capone", "given": "Stefania", "initials": "S"}, {"family": "Antinori", "given": "Andrea", "initials": "A"}, {"family": "Milleri", "given": "Stefano", "initials": "S"}, {"family": "Nicastri", "given": "Emanuele", "initials": "E"}, {"family": "Camerini", "given": "Roberto", "initials": "R"}, {"family": "Agrati", "given": "Chiara", "initials": "C"}, {"family": "Castilletti", "given": "Concetta", "initials": "C"}, {"family": "Mori", "given": "Federica", "initials": "F"}, {"family": "Sacchi", "given": "Alessandra", "initials": "A"}, {"family": "Matusali", "given": "Giulia", "initials": "G"}, {"family": "Gagliardini", "given": "Roberta", "initials": "R"}, {"family": "Ammendola", "given": "Virginia", "initials": "V"}, {"family": "Cimini", "given": "Eleonora", "initials": "E"}, {"family": "Grazioli", "given": "Fabiana", "initials": "F"}, {"family": "Scorzolini", "given": "Laura", "initials": "L"}, {"family": "Napolitano", "given": "Federico", "initials": "F"}, {"family": "Piazzi", "given": "Maria Maddalena", "initials": "MM"}, {"family": "Soriani", "given": "Marco", "initials": "M"}, {"family": "De Luca", "given": "Aldo", "initials": "A"}, {"family": "Battella", "given": "Simone", "initials": "S"}, {"family": "Sommella", "given": "Andrea", "initials": "A"}, {"family": "Contino", "given": "Alessandra M", "initials": "AM"}, {"family": "Barra", "given": "Federica", "initials": "F"}, {"family": "Gentile", "given": "Michela", "initials": "M"}, {"family": "Raggioli", "given": "Angelo", "initials": "A"}, {"family": "Shi", "given": "Yufang", "initials": "Y"}, {"family": "Girardi", "given": "Enrico", "initials": "E"}, {"family": "Maeurer", "given": "Markus", "initials": "M"}, {"family": "Capobianchi", "given": "Maria R", "initials": "MR"}, {"family": "Vaia", "given": "Francesco", "initials": "F"}, {"family": "Piacentini", "given": "Mauro", "initials": "M"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}, {"family": "Vitelli", "given": "Alessandra", "initials": "A"}, {"family": "Colloca", "given": "Stefano", "initials": "S"}, {"family": "Folgori", "given": "Antonella", "initials": "A"}, {"family": "Ippolito", "given": "Giuseppe", "initials": "G"}], "type": "posted-content", "published": "2021-04-13", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.10.21255202", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT04528641", "description": "Cinical trials of GRAd-COV2, a vaccine candidate based on an adenoviral vector derived from a group C Gorilla adenovirus"}], "notes": [], "created": "2021-05-29T16:44:59.400Z", "modified": "2021-11-18T09:44:28.193Z"}, {"entity": "publication", "iuid": "95f9816c0e174280b914ea2b935abbc7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95f9816c0e174280b914ea2b935abbc7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95f9816c0e174280b914ea2b935abbc7"}}, "title": "Does International Travel Frequency Affect COVID-19 Biosecurity Behavior in the United States?", "authors": [{"family": "Kim", "given": "Myung Ja", "initials": "MJ"}, {"family": "Hall", "given": "C Michael", "initials": "CM"}, {"family": "Bonn", "given": "Mark", "initials": "M"}], "type": "journal article", "published": "2021-04-13", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "8", "issn-l": null}, "abstract": "High-quality biosecurity practices are critical to restarting international tourism. Effective market segmentation improves the communication and efficacy of health advice. Travel frequency is an important basis for health-related consumer segmentation, as it is closely related to risk of greater exposure to infectious diseases. Theoretically grounded studies of tourist biosecurity behavior and travel frequency have largely been neglected, although insights into practices and attitudes are especially relevant for coronavirus disease of 2019 (COVID-19 (coronavirus disease of 2019) health responses. Therefore, this research constructed and tested a conceptual model applying Value-Attitude-Behavior theory to US travelers to see whether the frequency of international travel affected tourist COVID-19 related biosecurity behavior. US respondents were drawn from a panel using a quota sampling technique according to the age and gender of American outbound tourists. An online survey was administered in September 2020. The responses (n = 395) of those who traveled internationally within five years were analyzed utilizing partial least squares-structural equation modeling (PLS-SEM) with multi-group analysis. Travel frequency significantly affects biosecurity behavior. High travel frequency (\u22658 trips) has the strongest effect of value on biosecurity attitudes, personal norms, social norms, and biosecurity social norms, leading to biosecurity behaviors. Biosecurity behaviors pertaining to medium travel frequency (4-7 trips) are significantly influenced by personal norms. At low travel frequency (1-3 trips) levels, biosecurity behaviors are stimulated by biosecurity attitudes and social norms, showing the highest predictive power among the three groups. This work provides insights into international travel consumer biosecurity practices and behavior. From a market segmentation perspective, the levels of international travel frequency have various influences on biosecurity values, attitudes, personal norms, social norms, and behaviors. The biosecurity behaviors of low-frequency travelers are found to be the most significant of the three groups, suggesting that individuals who travel less frequently are more likely to practice responsible COVID-19 biosecurity behavior.", "doi": "10.3390/ijerph18084111", "pmid": "33924641", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "ijerph18084111"}, {"db": "pmc", "key": "PMC8068867"}], "notes": [], "created": "2021-05-04T16:22:01.814Z", "modified": "2021-05-04T16:22:01.829Z"}, {"entity": "publication", "iuid": "2a61f282b9484a34bfe7e8b39ea3d2f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2a61f282b9484a34bfe7e8b39ea3d2f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2a61f282b9484a34bfe7e8b39ea3d2f4"}}, "title": "A Deferred-Vaccination Design to Assess Durability of COVID-19 Vaccine Effect After the Placebo Group Is Vaccinated.", "authors": [{"family": "Follmann", "given": "Dean", "initials": "D"}, {"family": "Fintzi", "given": "Jonathan", "initials": "J"}, {"family": "Fay", "given": "Michael P", "initials": "MP"}, {"family": "Janes", "given": "Holly E", "initials": "HE"}, {"family": "Baden", "given": "Lindsey R", "initials": "LR"}, {"family": "El Sahly", "given": "Hana M", "initials": "HM"}, {"family": "Fleming", "given": "Thomas R", "initials": "TR"}, {"family": "Mehrotra", "given": "Devan V", "initials": "DV"}, {"family": "Carpp", "given": "Lindsay N", "initials": "LN"}, {"family": "Juraska", "given": "Michal", "initials": "M"}, {"family": "Benkeser", "given": "David", "initials": "D"}, {"family": "Donnell", "given": "Deborah", "initials": "D"}, {"family": "Fong", "given": "Youyi", "initials": "Y"}, {"family": "Han", "given": "Shu", "initials": "S"}, {"family": "Hirsch", "given": "Ian", "initials": "I"}, {"family": "Huang", "given": "Ying", "initials": "Y"}, {"family": "Huang", "given": "Yunda", "initials": "Y"}, {"family": "Hyrien", "given": "Ollivier", "initials": "O"}, {"family": "Luedtke", "given": "Alex", "initials": "A"}, {"family": "Carone", "given": "Marco", "initials": "M"}, {"family": "Nason", "given": "Martha", "initials": "M"}, {"family": "Vandebosch", "given": "An", "initials": "A"}, {"family": "Zhou", "given": "Honghong", "initials": "H"}, {"family": "Cho", "given": "Iksung", "initials": "I"}, {"family": "Gabriel", "given": "Erin", "initials": "E"}, {"family": "Kublin", "given": "James G", "initials": "JG"}, {"family": "Cohen", "given": "Myron S", "initials": "MS"}, {"family": "Corey", "given": "Lawrence", "initials": "L"}, {"family": "Gilbert", "given": "Peter B", "initials": "PB"}, {"family": "Neuzil", "given": "Kathleen M", "initials": "KM"}], "type": "journal article", "published": "2021-04-13", "journal": {"title": "Ann Intern Med", "issn": "1539-3704", "volume": null, "issue": null, "issn-l": "0003-4819"}, "abstract": "Multiple candidate vaccines to prevent COVID-19 have entered large-scale phase 3 placebo-controlled randomized clinical trials, and several have demonstrated substantial short-term efficacy. At some point after demonstration of substantial efficacy, placebo recipients should be offered the efficacious vaccine from their trial, which will occur before longer-term efficacy and safety are known. The absence of a placebo group could compromise assessment of longer-term vaccine effects. However, by continuing follow-up after vaccination of the placebo group, this study shows that placebo-controlled vaccine efficacy can be mathematically derived by assuming that the benefit of vaccination over time has the same profile for the original vaccine recipients and the original placebo recipients after their vaccination. Although this derivation provides less precise estimates than would be obtained by a standard trial where the placebo group remains unvaccinated, this proposed approach allows estimation of longer-term effect, including durability of vaccine efficacy and whether the vaccine eventually becomes harmful for some. Deferred vaccination, if done open-label, may lead to riskier behavior in the unblinded original vaccine group, confounding estimates of long-term vaccine efficacy. Hence, deferred vaccination via blinded crossover, where the vaccine group receives placebo and vice versa, would be the preferred way to assess vaccine durability and potential delayed harm. Deferred vaccination allows placebo recipients timely access to the vaccine when it would no longer be proper to maintain them on placebo, yet still allows important insights about immunologic and clinical effectiveness over time.", "doi": "10.7326/M20-8149", "pmid": "33844575", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-04-13T10:23:58.229Z", "modified": "2021-06-09T19:27:27.661Z"}, {"entity": "publication", "iuid": "734e379716ef4c33beee223fbf443d36", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/734e379716ef4c33beee223fbf443d36.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/734e379716ef4c33beee223fbf443d36"}}, "title": "UNRAVELING THE THREAD OF UNCONTROLLED IMMUNE RESPONSE IN COVID-19 AND STEMI: AN EMERGING NEED FOR KNOWLEDGE SHARING.", "authors": [{"family": "Rios-Navarro", "given": "Cesar", "initials": "C"}, {"family": "de Dios", "given": "Elena", "initials": "E"}, {"family": "Forteza", "given": "Maria J", "initials": "MJ"}, {"family": "Bodi", "given": "Vicente", "initials": "V"}], "type": "journal article", "published": "2021-04-12", "journal": {"title": "Am J Physiol Heart Circ Physiol", "issn": "1522-1539", "volume": null, "issue": null, "issn-l": null}, "abstract": "The outbreak of severe acute respiratory syndrome coronavirus 2 that first emerged in Wuhan in December 2019 has resulted in the devastating pandemic of coronavirus disease 2019, creating an emerging need for knowledge sharing. Meanwhile, myocardial infarction is and will probably remain the foremost cause of death in the western world throughout the coming decades. Severe deregulation of the immune system can unnecessarily expand the inflammatory response and participate in target and multiple organ failure, in infection but also in critical illness. Indeed, the course and fate of inflammatory cells observed in severe ST-elevation myocardial infarction (neutrophilia, monocytosis and lymphopenia) almost perfectly mirror those recently reported in severe coronavirus disease 2019. A pleiotropic proinflammatory imbalance hampers adaptive immunity in favor of uncontrolled innate immunity and is associated with poorer structural and clinical outcomes. The goal of the present review is to gain greater insight into the cellular and molecular mechanisms underlying this canonical activation and downregulation of the two arms of the immune response in both entities, to better understand their pathophysiology as well as to open the door to innovative therapeutic options. Knowledge sharing can pave the way for therapies with the potential to significantly reduce mortality in both infectious and non-infectious scenarios.", "doi": "10.1152/ajpheart.00934.2020", "pmid": "33844596", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-04-13T10:24:51.869Z", "modified": "2021-04-13T10:25:49.802Z"}, {"entity": "publication", "iuid": "89838a83ae4e439b8431bd07607f3dd6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/89838a83ae4e439b8431bd07607f3dd6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/89838a83ae4e439b8431bd07607f3dd6"}}, "title": "Psychological distress among health professional students during the COVID-19 outbreak - Corrigendum.", "authors": [{"family": "Li", "given": "Yuchen", "initials": "Y"}, {"family": "Wang", "given": "Yue", "initials": "Y"}, {"family": "Jiang", "given": "Jingwen", "initials": "J"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Fall", "given": "Katja", "initials": "K"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Song", "given": "Huan", "initials": "H"}, {"family": "Lu", "given": "Donghao", "initials": "D"}, {"family": "Zhang", "given": "Wei", "initials": "W"}], "type": "journal article", "published": "2021-04-12", "journal": {"title": "Psychol Med", "issn": "1469-8978", "issn-l": "0033-2917", "volume": null, "issue": null, "pages": "1"}, "abstract": null, "doi": "10.1017/S0033291721000714", "pmid": "33843513", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0033291721000714"}], "notes": [], "created": "2021-04-13T10:20:05.981Z", "modified": "2021-07-14T06:59:46.032Z"}, {"entity": "publication", "iuid": "f5e0b6f1a3454be68c578886559abd14", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f5e0b6f1a3454be68c578886559abd14.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f5e0b6f1a3454be68c578886559abd14"}}, "title": "How much is good enough? Insights from myocardial infarction incidence during COVID-19 pandemic.", "authors": [{"family": "Fedorowski", "given": "Artur", "initials": "A"}, {"family": "Erlinge", "given": "David", "initials": "D"}], "type": "editorial", "published": "2021-04-12", "journal": {"title": "Int J Cardiol", "issn": "1874-1754", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/j.ijcard.2021.04.020", "pmid": "33857541", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0167-5273(21)00656-2"}], "notes": [], "created": "2021-04-19T09:54:49.854Z", "modified": "2021-04-29T16:33:48.001Z"}, {"entity": "publication", "iuid": "e3290821941b4153ad8069aac785985e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3290821941b4153ad8069aac785985e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3290821941b4153ad8069aac785985e"}}, "title": "An episode of oral mucositis after the first administration of the ChAdOx1 COVID-19 vaccine.", "authors": [{"family": "Azzi", "given": "Lorenzo", "initials": "L"}, {"family": "Toia", "given": "Marco", "initials": "M"}, {"family": "Stevanello", "given": "Nicole", "initials": "N"}, {"family": "Maggi", "given": "Fabrizio", "initials": "F"}, {"family": "Forlani", "given": "Greta", "initials": "G"}], "type": "letter", "published": "2021-04-12", "journal": {"title": "Oral Dis", "issn": "1601-0825", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1111/odi.13874", "pmid": "33844386", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-13T10:22:50.951Z", "modified": "2021-04-13T10:23:14.796Z"}, {"entity": "publication", "iuid": "0a5e0740e18b4707946abdb229678dc8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a5e0740e18b4707946abdb229678dc8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a5e0740e18b4707946abdb229678dc8"}}, "title": "Management of endocrine surgical disorders during COVID-19 pandemic: expert opinion for non-surgical options.", "authors": [{"family": "Agcaoglu", "given": "Orhan", "initials": "O"}, {"family": "Sezer", "given": "Atakan", "initials": "A"}, {"family": "Makay", "given": "Ozer", "initials": "O"}, {"family": "Erdogan", "given": "Murat Faik", "initials": "MF"}, {"family": "Bayram", "given": "Fahri", "initials": "F"}, {"family": "Guldiken", "given": "Sibel", "initials": "S"}, {"family": "Raffaelli", "given": "Marco", "initials": "M"}, {"family": "Sonmez", "given": "Yusuf Alper", "initials": "YA"}, {"family": "Lee", "given": "Yong-Sang", "initials": "YS"}, {"family": "Vamvakidis", "given": "Kyriakos", "initials": "K"}, {"family": "Mihai", "given": "Radu", "initials": "R"}, {"family": "Duh", "given": "Quan-Yang", "initials": "QY"}, {"family": "Akinci", "given": "Baris", "initials": "B"}, {"family": "Alagol", "given": "Faruk", "initials": "F"}, {"family": "Almquist", "given": "Martin", "initials": "M"}, {"family": "Barczynski", "given": "Marcin", "initials": "M"}, {"family": "Bayraktaroglu", "given": "Taner", "initials": "T"}, {"family": "Berber", "given": "Eren", "initials": "E"}, {"family": "Bukey", "given": "Yusuf", "initials": "Y"}, {"family": "Cakmak", "given": "Guldeniz Karadeniz", "initials": "GK"}, {"family": "Canturk", "given": "Nuh Zafer", "initials": "NZ"}, {"family": "Canturk", "given": "Zeynep", "initials": "Z"}, {"family": "Celik", "given": "Mehmet", "initials": "M"}, {"family": "Celik", "given": "Ozlem", "initials": "O"}, {"family": "Ceyhan", "given": "Banu Ozturk", "initials": "BO"}, {"family": "Cherenko", "given": "Sergii", "initials": "S"}, {"family": "Clerici", "given": "Thomas", "initials": "T"}, {"family": "Coombes", "given": "David Scott", "initials": "DS"}, {"family": "Demircan", "given": "Orhan", "initials": "O"}, {"family": "Deyneli", "given": "Oguzhan", "initials": "O"}, {"family": "Dionigi", "given": "Gianlorenzo", "initials": "G"}, {"family": "Emre", "given": "Ali Ugur", "initials": "AU"}, {"family": "Erbil", "given": "Yesim", "initials": "Y"}, {"family": "Filiz", "given": "Ali Ilker", "initials": "AI"}, {"family": "Gozu", "given": "Hulya Il\u0131ksu", "initials": "HI"}, {"family": "Gurdal", "given": "Sibel Ozkan", "initials": "SO"}, {"family": "Gurleyik", "given": "Gunay", "initials": "G"}, {"family": "Haciyanli", "given": "Mehmet", "initials": "M"}, {"family": "Kebudi", "given": "Abut", "initials": "A"}, {"family": "Kim", "given": "Seokmo", "initials": "S"}, {"family": "Koutelidakis", "given": "Giannis", "initials": "G"}, {"family": "Kuru", "given": "Bekir", "initials": "B"}, {"family": "Mert", "given": "Meral", "initials": "M"}, {"family": "Oruk", "given": "Guzide Gonca", "initials": "GG"}, {"family": "Ozbas", "given": "Serdar", "initials": "S"}, {"family": "Palazzo", "given": "Fausto", "initials": "F"}, {"family": "Pandev", "given": "Rumen", "initials": "R"}, {"family": "Riss", "given": "Phillip", "initials": "P"}, {"family": "Sabuncu", "given": "Tevfik", "initials": "T"}, {"family": "Sahin", "given": "Ibrahim", "initials": "I"}, {"family": "Sakman", "given": "Gurhan", "initials": "G"}, {"family": "Saygili", "given": "Fusun", "initials": "F"}, {"family": "Senyurek", "given": "Yasemin Giles", "initials": "YG"}, {"family": "Sleptsov", "given": "Ilya", "initials": "I"}, {"family": "Van Slycke", "given": "Sam", "initials": "S"}, {"family": "Teksoz", "given": "Serkan", "initials": "S"}, {"family": "Terzioglu", "given": "Tarik", "initials": "T"}, {"family": "Tezelman", "given": "Serdar", "initials": "S"}, {"family": "Tunca", "given": "Fatih", "initials": "F"}, {"family": "Ugurlu", "given": "Mustafa Umit", "initials": "MU"}, {"family": "Uludag", "given": "Mehmet", "initials": "M"}, {"family": "Villar-Del-Moral", "given": "Jesus", "initials": "J"}, {"family": "Vriens", "given": "Menno", "initials": "M"}, {"family": "Yazici", "given": "Dilek", "initials": "D"}], "type": "journal article", "published": "2021-04-11", "journal": {"title": "Updates Surg", "issn": "2038-3312", "volume": null, "issue": null, "issn-l": null}, "abstract": "The COVID-19 pandemic brought unprecedented conditions for overall health care systems by restricting resources for non-COVID-19 patients. As the burden of the disease escalates, routine elective surgeries are being cancelled. The aim of this paper was to provide a guideline for management of endocrine surgical disorders during a pandemic.\n\nWe used Delphi method with a nine-scale Likert scale on two rounds of voting involving 64 experienced eminent surgeons and endocrinologists who had the necessary experience to provide insight on endocrine disorder management. All voting was done by email using a standard questionnaire.\n\nOverall, 37 recommendations were voted on. In two rounds, all recommendations reached an agreement and were either endorsed or rejected. Endorsed statements include dietary change in primary hyperparathyroidism, Cinacalcet treatment in secondary hyperparathyroidism, alpha-blocker administration for pheochromocytoma, methimazole \u00b1 \u03b2-blocker combination for Graves' disease, and follow-up for fine-needle aspiration results of thyroid nodules indicated as Bethesda 3-4 cytological results and papillary microcarcinoma.\n\nThis survey summarizes expert opinion for the management of endocrine surgical conditions during unprecedented times when access to surgical treatment is severely disrupted. The statements are not applicable in circumstances in which surgical treatment is possible.", "doi": "10.1007/s13304-021-00979-8", "pmid": "33840069", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s13304-021-00979-8"}], "notes": [], "created": "2021-04-12T15:37:06.442Z", "modified": "2021-04-12T15:37:06.457Z"}, {"entity": "publication", "iuid": "0093b6ff3d9e4e7d9eb384ae94e166c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0093b6ff3d9e4e7d9eb384ae94e166c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0093b6ff3d9e4e7d9eb384ae94e166c5"}}, "title": "Suggestions for Shaping Tinnitus Service Provision in Western Europe: Lessons from the COVID-19 Pandemic.", "authors": [{"family": "Beukes", "given": "Eldr\u00e9 W", "initials": "EW"}, {"family": "Lourenco", "given": "Matheus P C G", "initials": "MPCG"}, {"family": "Biot", "given": "Lana", "initials": "L"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Kaldo", "given": "Viktor", "initials": "V"}, {"family": "Manchaiah", "given": "Vinaya", "initials": "V"}, {"family": "Jacquemin", "given": "Laure", "initials": "L"}], "type": "journal article", "published": "2021-04-10", "journal": {"title": "Int J Clin Pract", "issn": "1742-1241", "volume": null, "issue": null, "pages": "e14196", "issn-l": null}, "abstract": "Tinnitus severity has been exacerbated due to the COVID-19 pandemic and those with tinnitus require additional support. Such support should be informed by patient preferences and needs. The objective of this study was to gather information from individuals with tinnitus living in Europe to inform stakeholders of the (i) support they needed in relation to changes associated with the COVID-19 pandemic, and (ii) suggestions regarding tinnitus care for the future.\n\nA cross-sectional mixed methods study design was used using closed and open-ended questions via an online survey. Data was gathered from 710 adults experiencing tinnitus in Western Europe, with the majority living in The Netherlands, Belgium, and Sweden. Data were analysed using qualitative content analysis and descriptive statistics.\n\nThose with tinnitus indicated the following support needs during the pandemic (a) support for tinnitus, (b) support for hearing-related difficulties, (c) social support, and (d) pandemic-related support. Five directions for future tinnitus care were provided, namely (a) need for understanding professional support and access to multidisciplinary experts, (b) greater range of therapies and resources, (c) access to more information about tinnitus, (d) prioritizing tinnitus research, and (e) more support for hearing protection and hearing loss prevention CONCLUSIONS: The findings point to the need for accessible (remote), patient-centred, suitable and evidence-based tinnitus care. Insights from the current study can be used by various stakeholders including clinical practitioners and tinnitus support services to ensure those with tinnitus have access to the help and support required in order to reduce service provision insufficiencies.", "doi": "10.1111/ijcp.14196", "pmid": "33837639", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-12T15:38:24.625Z", "modified": "2021-04-12T15:38:24.647Z"}, {"entity": "publication", "iuid": "f0c96d0826084273911cf71b16584504", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f0c96d0826084273911cf71b16584504.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f0c96d0826084273911cf71b16584504"}}, "title": "Real-world evidence and product development: Opportunities, challenges and risk mitigation.", "authors": [{"family": "Naidoo", "given": "Poobalan", "initials": "P"}, {"family": "Bouharati", "given": "C\u00e9lia", "initials": "C"}, {"family": "Rambiritch", "given": "Virendra", "initials": "V"}, {"family": "Jose", "given": "Nadina", "initials": "N"}, {"family": "Karamchand", "given": "Sumanth", "initials": "S"}, {"family": "Chilton", "given": "Robert", "initials": "R"}, {"family": "Leisegang", "given": "Rory", "initials": "R"}], "type": "journal article", "published": "2021-04-09", "journal": {"title": "Wien Klin Wochenschr", "issn": "0043-5325", "volume": null, "issue": null, "issn-l": null}, "abstract": "Real-world evidence (RWE) is derived from real-world data (RWD) sources including electronic health records, claims data, registries (disease, product) and pragmatic clinical trials. The importance of RWE derived from RWD has been once again demonstrated during the coronavirus disease 2019 (COVID-19) pandemic, as it can improve patient care by complementing information obtained from traditional clinical trial programs. Additionally, RWE can generate insights into disease mechanisms, epidemiology, patient flows in and out of healthcare systems, and drivers and barriers to optimal clinical care in real-world settings. Identifying unmet medical needs is crucial as it often can inform which investigational new drugs enter clinical trial testing, and RWE studies from hospital settings have contributed substantial progress here. RWE can also optimize the design of clinical studies, inform benefit risk assessments and use networks of pragmatic studies to help with clinical trial feasibilities and eventual trial initiation. The challenges of RWD include data quality, reproducibility and accuracy which may affect validity. RWD and RWE must be fit for purpose and one must be cognizant of inherent biases.", "doi": "10.1007/s00508-021-01851-w", "pmid": "33837463", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00508-021-01851-w"}], "notes": [], "created": "2021-04-12T16:08:25.904Z", "modified": "2021-04-12T16:08:57.222Z"}, {"entity": "publication", "iuid": "7e93d0de8ee847b78624def331e2cbe7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e93d0de8ee847b78624def331e2cbe7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e93d0de8ee847b78624def331e2cbe7"}}, "title": "Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial.", "authors": [{"family": "Ramakrishnan", "given": "Sanjay", "initials": "S"}, {"family": "Nicolau", "given": "Dan V", "initials": "DV"}, {"family": "Langford", "given": "Beverly", "initials": "B"}, {"family": "Mahdi", "given": "Mahdi", "initials": "M"}, {"family": "Jeffers", "given": "Helen", "initials": "H"}, {"family": "Mwasuku", "given": "Christine", "initials": "C"}, {"family": "Krassowska", "given": "Karolina", "initials": "K"}, {"family": "Fox", "given": "Robin", "initials": "R"}, {"family": "Binnian", "given": "Ian", "initials": "I"}, {"family": "Glover", "given": "Victoria", "initials": "V"}, {"family": "Bright", "given": "Stephen", "initials": "S"}, {"family": "Butler", "given": "Christopher", "initials": "C"}, {"family": "Cane", "given": "Jennifer L", "initials": "JL"}, {"family": "Halner", "given": "Andreas", "initials": "A"}, {"family": "Matthews", "given": "Philippa C", "initials": "PC"}, {"family": "Donnelly", "given": "Louise E", "initials": "LE"}, {"family": "Simpson", "given": "Jodie L", "initials": "JL"}, {"family": "Baker", "given": "Jonathan R", "initials": "JR"}, {"family": "Fadai", "given": "Nabil T", "initials": "NT"}, {"family": "Peterson", "given": "Stefan", "initials": "S"}, {"family": "Bengtsson", "given": "Thomas", "initials": "T"}, {"family": "Barnes", "given": "Peter J", "initials": "PJ"}, {"family": "Russell", "given": "Richard E K", "initials": "REK"}, {"family": "Bafadhel", "given": "Mona", "initials": "M"}], "type": "journal article", "published": "2021-04-09", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "volume": null, "issue": null, "issn-l": "2213-2600"}, "abstract": "Multiple early reports of patients admitted to hospital with COVID-19 showed that patients with chronic respiratory disease were significantly under-represented in these cohorts. We hypothesised that the widespread use of inhaled glucocorticoids among these patients was responsible for this finding, and tested if inhaled glucocorticoids would be an effective treatment for early COVID-19.\n\nWe performed an open-label, parallel-group, phase 2, randomised controlled trial (Steroids in COVID-19; STOIC) of inhaled budesonide, compared with usual care, in adults within 7 days of the onset of mild COVID-19 symptoms. The trial was done in the community in Oxfordshire, UK. Participants were randomly assigned to inhaled budsonide or usual care stratified for age (\u226440 years or >40 years), sex (male or female), and number of comorbidities (\u22641 and \u22652). Randomisation was done using random sequence generation in block randomisation in a 1:1 ratio. Budesonide dry powder was delivered using a turbohaler at a dose of 800 \u03bcg per actuation. Participants were asked to take two inhalations twice a day until symptom resolution. The primary endpoint was COVID-19-related urgent care visit, including emergency department assessment or hospitalisation, analysed for both the per-protocol and intention-to-treat (ITT) populations. The secondary outcomes were self-reported clinical recovery (symptom resolution), viral symptoms measured using the Common Cold Questionnare (CCQ) and the InFLUenza Patient Reported Outcome Questionnaire (FLUPro), body temperature, blood oxygen saturations, and SARS-CoV-2 viral load. The trial was stopped early after independent statistical review concluded that study outcome would not change with further participant enrolment. This trial is registered with ClinicalTrials.gov, NCT04416399.\n\nFrom July 16 to Dec 9, 2020, 167 participants were recruited and assessed for eligibility. 21 did not meet eligibility criteria and were excluded. 146 participants were randomly assigned-73 to usual care and 73 to budesonide. For the per-protocol population (n=139), the primary outcome occurred in ten (14%) of 70 participants in the budesonide group and one (1%) of 69 participant in the usual care group (difference in proportions 0\u00b7131, 95% CI 0\u00b7043 to 0\u00b7218; p=0\u00b7004). For the ITT population, the primary outcome occurred in 11 (15%) participants in the usual care group and two (3%) participants in the budesonide group (difference in proportions 0\u00b7123, 95% CI 0\u00b7033 to 0\u00b7213; p=0\u00b7009). The number needed to treat with inhaled budesonide to reduce COVID-19 deterioration was eight. Clinical recovery was 1 day shorter in the budesonide group compared with the usual care group (median 7 days [95% CI 6 to 9] in the budesonide group vs 8 days [7 to 11] in the usual care group; log-rank test p=0\u00b7007). The mean proportion of days with a fever in the first 14 days was lower in the budesonide group (2%, SD 6) than the usual care group (8%, SD 18; Wilcoxon test p=0\u00b7051) and the proportion of participants with at least 1 day of fever was lower in the budesonide group when compared with the usual care group. As-needed antipyretic medication was required for fewer proportion of days in the budesonide group compared with the usual care group (27% [IQR 0-50] vs 50% [15-71]; p=0\u00b7025) Fewer participants randomly assigned to budesonide had persistent symptoms at days 14 and 28 compared with participants receiving usual care (difference in proportions 0\u00b7204, 95% CI 0\u00b7075 to 0\u00b7334; p=0\u00b7003). The mean total score change in the CCQ and FLUPro over 14 days was significantly better in the budesonide group compared with the usual care group (CCQ mean difference -0\u00b712, 95% CI -0\u00b721 to -0\u00b702 [p=0\u00b7016]; FLUPro mean difference -0\u00b710, 95% CI -0\u00b721 to -0\u00b700 [p=0\u00b7044]). Blood oxygen saturations and SARS-CoV-2 load, measured by cycle threshold, were not different between the groups. Budesonide was safe, with only five (7%) participants reporting self-limiting adverse events.\n\nEarly administration of inhaled budesonide reduced the likelihood of needing urgent medical care and reduced time to recovery after early COVID-19.\n\nNational Institute for Health Research Biomedical Research Centre and AstraZeneca.", "doi": "10.1016/S2213-2600(21)00160-0", "pmid": "33844996", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(21)00160-0"}, {"db": "ClinicalTrials.gov", "key": "NCT04416399"}], "notes": [], "created": "2021-04-13T10:27:27.629Z", "modified": "2021-04-13T10:29:15.226Z"}, {"entity": "publication", "iuid": "a6fc4c855acb4c7a8eeaf164395a1590", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6fc4c855acb4c7a8eeaf164395a1590.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6fc4c855acb4c7a8eeaf164395a1590"}}, "title": "Evaluating and optimizing COVID-19 vaccination policies: a case study of Sweden", "authors": [{"family": "Sj\u00f6din", "given": "Henrik", "initials": "H"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}, {"family": "Britton", "given": "Tom", "initials": "T"}], "type": "posted-content", "published": "2021-04-09", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.07.21255026", "pmid": null, "labels": {"Type: Preprint": null, "Category: Other": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-14T05:09:10.154Z", "modified": "2021-04-21T08:35:40.996Z"}, {"entity": "publication", "iuid": "1ddde94149764d01800ae09c16c2abed", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ddde94149764d01800ae09c16c2abed.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ddde94149764d01800ae09c16c2abed"}}, "title": "Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19.", "authors": [{"family": "Gaziano", "given": "Liam", "initials": "L"}, {"family": "Giambartolomei", "given": "Claudia", "initials": "C"}, {"family": "Pereira", "given": "Alexandre C", "initials": "AC"}, {"family": "Gaulton", "given": "Anna", "initials": "A"}, {"family": "Posner", "given": "Daniel C", "initials": "DC"}, {"family": "Swanson", "given": "Sonja A", "initials": "SA"}, {"family": "Ho", "given": "Yuk-Lam", "initials": "Y"}, {"family": "Iyengar", "given": "Sudha K", "initials": "SK"}, {"family": "Kosik", "given": "Nicole M", "initials": "NM"}, {"family": "Vujkovic", "given": "Marijana", "initials": "M"}, {"family": "Gagnon", "given": "David R", "initials": "DR"}, {"family": "Bento", "given": "A Patr\u00edcia", "initials": "AP"}, {"family": "Barrio-Hernandez", "given": "Inigo", "initials": "I"}, {"family": "R\u00f6nnblom", "given": "Lars", "initials": "L"}, {"family": "Hagberg", "given": "Niklas", "initials": "N"}, {"family": "Lundtoft", "given": "Christian", "initials": "C"}, {"family": "Langenberg", "given": "Claudia", "initials": "C"}, {"family": "Pietzner", "given": "Maik", "initials": "M"}, {"family": "Valentine", "given": "Dennis", "initials": "D"}, {"family": "Gustincich", "given": "Stefano", "initials": "S"}, {"family": "Tartaglia", "given": "Gian Gaetano", "initials": "GG"}, {"family": "Allara", "given": "Elias", "initials": "E"}, {"family": "Surendran", "given": "Praveen", "initials": "P"}, {"family": "Burgess", "given": "Stephen", "initials": "S"}, {"family": "Zhao", "given": "Jing Hua", "initials": "JH"}, {"family": "Peters", "given": "James E", "initials": "JE"}, {"family": "Prins", "given": "Bram P", "initials": "BP"}, {"family": "Angelantonio", "given": "Emanuele Di", "initials": "ED"}, {"family": "Devineni", "given": "Poornima", "initials": "P"}, {"family": "Shi", "given": "Yunling", "initials": "Y"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "DuVall", "given": "Scott L", "initials": "SL"}, {"family": "Garcon", "given": "Helene", "initials": "H"}, {"family": "Thomann", "given": "Lauren O", "initials": "LO"}, {"family": "Zhou", "given": "Jin J", "initials": "JJ"}, {"family": "Gorman", "given": "Bryan R", "initials": "BR"}, {"family": "Huffman", "given": "Jennifer E", "initials": "JE"}, {"family": "O'Donnell", "given": "Christopher J", "initials": "CJ"}, {"family": "Tsao", "given": "Philip S", "initials": "PS"}, {"family": "Beckham", "given": "Jean C", "initials": "JC"}, {"family": "Pyarajan", "given": "Saiju", "initials": "S"}, {"family": "Muralidhar", "given": "Sumitra", "initials": "S"}, {"family": "Huang", "given": "Grant D", "initials": "GD"}, {"family": "Ramoni", "given": "Rachel", "initials": "R"}, {"family": "Beltrao", "given": "Pedro", "initials": "P"}, {"family": "Danesh", "given": "John", "initials": "J"}, {"family": "Hung", "given": "Adriana M", "initials": "AM"}, {"family": "Chang", "given": "Kyong-Mi", "initials": "K"}, {"family": "Sun", "given": "Yan V", "initials": "YV"}, {"family": "Joseph", "given": "Jacob", "initials": "J"}, {"family": "Leach", "given": "Andrew R", "initials": "AR"}, {"family": "Edwards", "given": "Todd L", "initials": "TL"}, {"family": "Cho", "given": "Kelly", "initials": "K"}, {"family": "Gaziano", "given": "J Michael", "initials": "JM"}, {"family": "Butterworth", "given": "Adam S", "initials": "AS"}, {"family": "Casas", "given": "Juan P", "initials": "JP"}, {"family": "VA Million Veteran Program COVID-19 Science Initiative", "given": "", "initials": ""}], "type": "journal article", "published": "2021-04-09", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956", "volume": "27", "issue": "4", "pages": "668-676"}, "abstract": "Drug repurposing provides a rapid approach to meet the urgent need for therapeutics to address COVID-19. To identify therapeutic targets relevant to COVID-19, we conducted Mendelian randomization analyses, deriving genetic instruments based on transcriptomic and proteomic data for 1,263 actionable proteins that are targeted by approved drugs or in clinical phase of drug development. Using summary statistics from the Host Genetics Initiative and the Million Veteran Program, we studied 7,554 patients hospitalized with COVID-19 and >1 million controls. We found significant Mendelian randomization results for three proteins (ACE2, P = 1.6 \u00d7 10 -6; IFNAR2, P = 9.8 \u00d7 10-11 and IL-10RB, P = 2.3 \u00d7 10-14) using cis-expression quantitative trait loci genetic instruments that also had strong evidence for colocalization with COVID-19 hospitalization. To disentangle the shared expression quantitative trait loci signal for IL10RB and IFNAR2, we conducted phenome-wide association scans and pathway enrichment analysis, which suggested that IFNAR2 is more likely to play a role in COVID-19 hospitalization. Our findings prioritize trials of drugs targeting IFNAR2 and ACE2 for early management of COVID-19.", "doi": "10.1038/s41591-021-01310-z", "pmid": "33837377", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-021-01310-z"}, {"db": "GTEx project", "key": "https://gtexportal.org/home/.", "description": "GTEx project v.8 data"}, {"db": "CheMBL", "key": "https://www.ebi.ac.uk/chembl/", "description": "CheMBL database used to identify 1,263 human proteins as \u2018actionable\u2019 (therapeutic targets of approved or clinical-stage drugs) for SARS-COV2"}, {"db": "Fenland-SomaLogic protein GWAS data", "key": "https://omicscience.org/apps/covidpgwas/", "description": null}, {"db": "COVID-19 hospitalization data", "key": "https://www.covid19hg.org/", "description": "HGI COVID-19 hospitalization summary statistics"}, {"db": "phenoscanner", "key": "http://www.phenoscanner.medschl.cam.ac.uk/", "description": "PhenoScanner results for searching proteins, traits and diseases"}], "notes": [], "created": "2021-04-12T16:09:55.811Z", "modified": "2021-11-18T09:22:55.307Z"}, {"entity": "publication", "iuid": "e95d0be8d9a041e7bd1859fa613ee7cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e95d0be8d9a041e7bd1859fa613ee7cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e95d0be8d9a041e7bd1859fa613ee7cc"}}, "title": "Safety of Esophageal Cancer Surgery During the First Wave of the COVID-19 Pandemic in Europe: A Multicenter Study.", "authors": [{"family": "Borgstein", "given": "Alexander B J", "initials": "ABJ"}, {"family": "Brunner", "given": "Stefanie", "initials": "S"}, {"family": "Hayami", "given": "Masaru", "initials": "M"}, {"family": "Moons", "given": "Johnny", "initials": "J"}, {"family": "Fuchs", "given": "Hans", "initials": "H"}, {"family": "Eshuis", "given": "Wietse J", "initials": "WJ"}, {"family": "Gisbertz", "given": "Suzanne S", "initials": "SS"}, {"family": "Bruns", "given": "Christiane J", "initials": "CJ"}, {"family": "Nafteux", "given": "Philippe", "initials": "P"}, {"family": "Nilsson", "given": "Magnus", "initials": "M"}, {"family": "Schr\u00f6der", "given": "Wolfgang", "initials": "W"}, {"family": "van Berge Henegouwen", "given": "Mark I", "initials": "MI"}], "type": "journal article", "published": "2021-04-08", "journal": {"title": "Ann Surg Oncol", "issn": "1534-4681", "volume": null, "issue": null, "issn-l": null}, "abstract": "Many hospitals postponed elective surgical care during the first wave of the coronavirus disease 2019 (COVID-19) pandemic. Some centers continued elective surgery, including esophageal cancer surgery, with the use of preoperative screening methods; however, there is no evidence supporting the safety of this strategy as postoperative outcomes after esophageal cancer surgery during the COVID-19 pandemic have not yet been investigated.\n\nThis multicenter study in four European tertiary esophageal cancer referral centers included consecutive adult patients undergoing elective esophageal cancer surgery from a prospectively maintained database in a COVID-19 pandemic cohort (1 March 2020-31 May 2020) and a control cohort (1 October 2019-29 February 2020). The primary outcome was the rate of respiratory failure requiring mechanical ventilation.\n\nThe COVID-19 cohort consisted of 139 patients, versus 168 patients in the control cohort. There was no difference in the rate of respiratory failure requiring mechanical ventilation (13.7% vs. 8.3%, p = 0.127) and number of pulmonary complications (32.4% vs. 29.9%, p = 0.646) between the COVID-19 cohort and the control cohort. Overall, postoperative morbidity and mortality rates were comparable between both cohorts. History taking and reverse transcription polymerase chain reaction (RT-PCR) were used as preoperative screening methods to detect a possible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in all centers. No patients were diagnosed with COVID-19 pre- or postoperatively.\n\nEsophageal cancer surgery during the first wave of the COVID-19 pandemic was not associated with an increase in pulmonary complications as no patients were diagnosed with COVID-19. Esophageal cancer surgery can be performed safely with the use of adequate preoperative SARS-CoV-2 screening methods.", "doi": "10.1245/s10434-021-09886-z", "pmid": "33830357", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1245/s10434-021-09886-z"}], "notes": [], "created": "2021-04-09T16:45:24.369Z", "modified": "2021-04-09T16:45:24.393Z"}, {"entity": "publication", "iuid": "0c3bea1d568149e89b08f349a0786114", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c3bea1d568149e89b08f349a0786114.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c3bea1d568149e89b08f349a0786114"}}, "title": "Platelet count rose while D-dimer levels dropped as deaths and thrombosis declined, an observational study on anticoagulation shift in COVID-19.", "authors": [{"family": "Sj\u00f6str\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Wers\u00e4ll", "given": "Johanna", "initials": "J"}, {"family": "Warnqvist", "given": "Anna", "initials": "A"}, {"family": "Farm", "given": "Maria", "initials": "M"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Oldner", "given": "Anders", "initials": "A"}, {"family": "\u00c5gren", "given": "Anna", "initials": "A"}, {"family": "Antovic", "given": "Jovan P", "initials": "JP"}, {"family": "Bruzelius", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-04-08", "journal": {"title": "Thromb Haemost", "issn": "2567-689X", "volume": null, "issue": null, "issn-l": "0340-6245"}, "abstract": "High levels of D-dimer and low platelet counts are associated with poor outcome in COVID-19. As anticoagulation appeared to improve survival, hospital-wide recommendations regarding higher doses of anticoagulation was implemented 4/9/2020.\n\nTo investigate if trends in D-dimer levels and platelet counts associated with death, thrombosis, and the shift in anticoagulation.\n\nRetrospective cohort study of 429 patients with COVID-19 at Karolinska University Hospital. Information on D-dimer levels and platelet counts was obtained from laboratory databases and clinical data from medical records.\n\nThirty-day mortality and thrombosis rate was 19% and 18%, respectively. Pulmonary embolism was common; 65/83 (78%). Increased D-dimer levels the first week in hospital were significantly associated with death and thrombosis (OR 6.06; 95% Cl 2.10-17.5, and 3.11; 95% CI 1.20-8.10, respectively). If platelet count increased more than 35\u00d7109/L per day, the mortality and thrombotic risk decreased (OR 0.16; 95% CI 0.06-0.41, and OR 0.36; 95% CI 0.17-0.80). After implementation of updated hospital-wide recommendations, the daily mean significantly decreased regarding D-dimer levels while platelet counts rose; -1.93; 95% CI -1.00-2.87 mg/L FEU and 65; 95% CI 54-76 \u00d7109/L and significant risk reductions for death and thrombosis were observed; OR 0.48; 95% CI 0.25-0.92 and 0.35; 95% CI 0.17-0.72.\n\nIn contrast to D-dimer levels, increase of platelet count over the first week in-hospital was associated with improved survival and reduced thrombotic risk. The daily mean levels of D-dimer dropped while the platelet counts rose, coinciding with increased anticoagulation and a decline in thrombotic burden and mortality.", "doi": "10.1055/a-1477-3829", "pmid": "33831964", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-09T16:47:21.673Z", "modified": "2021-04-09T16:47:21.683Z"}, {"entity": "publication", "iuid": "7419a7484d754917952a7b310334a8ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7419a7484d754917952a7b310334a8ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7419a7484d754917952a7b310334a8ef"}}, "title": "Estimation of Excess Mortality and Years of Life Lost to COVID-19 in Norway and Sweden between March and November 2020.", "authors": [{"family": "Rypdal", "given": "Martin", "initials": "M", "orcid": "0000-0003-0053-665X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eea43d9f775e446680aff49c4caf4a6e.json"}}, {"family": "Rypdal", "given": "Kristoffer", "initials": "K", "orcid": "0000-0001-9306-5441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf10bf2f114a497e990038fd1c8d9248.json"}}, {"family": "L\u00f8vsletten", "given": "Ola", "initials": "O", "orcid": "0000-0001-9483-9621", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3912eef1009b48c69b67fd71687b9776.json"}}, {"family": "S\u00f8rbye", "given": "Sigrunn Holbek", "initials": "SH", "orcid": "0000-0002-5818-1508", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4ca8694ab6947bfa1e8f7fdc9d084ea.json"}}, {"family": "Ytterstad", "given": "Elinor", "initials": "E", "orcid": "0000-0002-1203-1491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/33d836747a854f1592d920fa05bf7031.json"}}, {"family": "Bianchi", "given": "Filippo Maria", "initials": "FM", "orcid": "0000-0002-7145-3846", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5cc4d12290c64a3f8b406347f52f8c9b.json"}}], "type": "journal article", "published": "2021-04-08", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "8", "issn-l": null}, "abstract": "We estimate the weekly excess all-cause mortality in Norway and Sweden, the years of life lost (YLL) attributed to COVID-19 in Sweden, and the significance of mortality displacement. We computed the expected mortality by taking into account the declining trend and the seasonality in mortality in the two countries over the past 20 years. From the excess mortality in Sweden in 2019/20, we estimated the YLL attributed to COVID-19 using the life expectancy in different age groups. We adjusted this estimate for possible displacement using an auto-regressive model for the year-to-year variations in excess mortality. We found that excess all-cause mortality over the epidemic year, July 2019 to July 2020, was 517 (95%CI = (12, 1074)) in Norway and 4329 [3331, 5325] in Sweden. There were 255 COVID-19 related deaths reported in Norway, and 5741 in Sweden, that year. During the epidemic period of 11 March-11 November, there were 6247 reported COVID-19 deaths and 5517 (4701, 6330) excess deaths in Sweden. We estimated that the number of YLL attributed to COVID-19 in Sweden was 45,850 [13,915, 80,276] without adjusting for mortality displacement and 43,073 (12,160, 85,451) after adjusting for the displacement accounted for by the auto-regressive model. In conclusion, we find good agreement between officially recorded COVID-19 related deaths and all-cause excess deaths in both countries during the first epidemic wave and no significant mortality displacement that can explain those deaths.", "doi": "10.3390/ijerph18083913", "pmid": "33917872", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8068261"}, {"db": "pii", "key": "ijerph18083913"}], "notes": [], "created": "2023-01-13T13:43:05.800Z", "modified": "2023-01-13T13:43:07.279Z"}, {"entity": "publication", "iuid": "7f23907c2d4842f3afbc5d09b9b23b51", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f23907c2d4842f3afbc5d09b9b23b51.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f23907c2d4842f3afbc5d09b9b23b51"}}, "title": "Detection of SARS-CoV-2 RNA in the Danube River in Serbia associated with the discharge of untreated wastewaters.", "authors": [{"family": "Kolarevi\u0107", "given": "Stoimir", "initials": "S"}, {"family": "Micsinai", "given": "Adrienn", "initials": "A"}, {"family": "Sz\u00e1nt\u00f3-Eg\u00e9sz", "given": "R\u00e9ka", "initials": "R"}, {"family": "Luk\u00e1cs", "given": "Alena", "initials": "A"}, {"family": "Kra\u010dun-Kolarevi\u0107", "given": "Margareta", "initials": "M"}, {"family": "Lundy", "given": "Lian", "initials": "L"}, {"family": "Kirschner", "given": "Alexander K T", "initials": "AKT"}, {"family": "Farnleitner", "given": "Andreas H", "initials": "AH"}, {"family": "Djukic", "given": "Aleksandar", "initials": "A"}, {"family": "\u010coli\u0107", "given": "Jasna", "initials": "J"}, {"family": "Nenin", "given": "Tanja", "initials": "T"}, {"family": "Sunjog", "given": "Karolina", "initials": "K"}, {"family": "Paunovi\u0107", "given": "Momir", "initials": "M"}], "type": "journal article", "published": "2021-04-08", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "issn-l": "0048-9697", "volume": "783", "issue": null, "pages": "146967"}, "abstract": "In Serbia less than 13% of collected municipal wastewaters is being treated before their release in the environment. This includes all municipal wastewater discharges from Belgrade (capital city of Serbia; population 1,700,000). Previous research has identified the impacts of raw wastewater discharges from Belgrade on the Danube River, and this study investigated if such discharges also provided a pathway for SARS-CoV-2 RNA material. Samples were collected during the most critical circumstances that occurred so far within the COVID-19 pandemics in Serbia. Grab and composite samples were collected in December 2020, during the peak of the third wave (in terms of reported cases) at the site which receives the wastewater loads in Belgrade. Grab samples collected upstream and downstream of Belgrade were also analyzed. RNA was quantified using RT-qPCR with primer sets targeting nucleocapsid (N1 and N2) and envelope (E) protein genes. SARS-CoV-2 RNA (5.97 \u00d7 10 3 to 1.32 \u00d7 104 copies/L) was detected only in samples collected at the site strongly impacted by the wastewaters where all three applied primer sets gave positive signals. Determined concentrations correspond to those reported in wastewater influents sampled at treatment plants in other countries indicating an epidemiological indicator function of used approach for rivers with high pollution loads in countries with poor wastewater treatment.", "doi": "10.1016/j.scitotenv.2021.146967", "pmid": "33865136", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(21)02037-4"}], "notes": [], "created": "2021-04-19T10:40:03.905Z", "modified": "2021-06-21T14:49:12.299Z"}, {"entity": "publication", "iuid": "d2d1266ccd71494e829e3db102c467fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d2d1266ccd71494e829e3db102c467fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d2d1266ccd71494e829e3db102c467fa"}}, "title": "Acceptability of COVID-19 Vaccine in Africa", "authors": [{"family": "Sevidzem Wirsiy", "given": "Frankline", "initials": "F"}, {"family": "Nkfusai", "given": "Ngwayu Claude", "initials": "NC"}, {"family": "Ebot Ako-Arrey", "given": "Denis", "initials": "D"}, {"family": "Kenfack Dongmo", "given": "Esther", "initials": "E"}, {"family": "Titu Manjong", "given": "Florence", "initials": "F"}, {"family": "Nambile Cumber", "given": "Samuel", "initials": "S"}], "type": "journal-article", "published": "2021-04-08", "journal": {"title": "Int J MCH AIDS", "issn": "2161-864X", "volume": "10", "issue": "1", "pages": "134-138", "issn-l": null}, "abstract": null, "doi": "10.21106/ijma.482", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-04-20T17:55:23.466Z", "modified": "2021-04-20T17:55:23.489Z"}, {"entity": "publication", "iuid": "6c44a627afce4e37869d9a48b8ae9616", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c44a627afce4e37869d9a48b8ae9616.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c44a627afce4e37869d9a48b8ae9616"}}, "title": "Transmission of SARS-Cov-2 and other enveloped viruses to the environment through protective gear: a brief review.", "authors": [{"family": "Petrosino", "given": "Francesco", "initials": "F"}, {"family": "Mukherjee", "given": "Debolina", "initials": "D"}, {"family": "Coppola", "given": "Gerardo", "initials": "G"}, {"family": "Gaudio", "given": "Maria Teresa", "initials": "MT"}, {"family": "Curcio", "given": "Stefano", "initials": "S"}, {"family": "Calabro", "given": "Vincenza", "initials": "V"}, {"family": "Marra", "given": "Francesco", "initials": "F"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Pal", "given": "Umapada", "initials": "U"}, {"family": "Kh\u00e9lifi", "given": "Nabil", "initials": "N"}, {"family": "Chakraborty", "given": "Sudip", "initials": "S"}], "type": "journal article", "published": "2021-04-07", "journal": {"title": "EuroMediterr J Environ Integr", "issn": "2365-7448", "volume": "6", "issue": "2", "pages": "48", "issn-l": null}, "abstract": "Over the past two decades, several deadly viral epidemics have emerged, which have placed humanity in danger. Previous investigations have suggested that viral diseases can spread through contaminants or contaminated surfaces. The transmission of viruses via polluted surfaces relies upon their capacity to maintain their infectivity while they are in the environment. Here, a range of materials that are widely used to manufacture personal protective equipment (PPE) are summarized, as these offer effective disinfection solutions and are the environmental variables that influence virus survival. Infection modes and prevention as well as disinfection and PPE disposal strategies are discussed. A coronavirus-like enveloped virus can live in the environment after being discharged from a host organism until it infects another healthy individual. Transmission of enveloped viruses such as SARS-CoV-2 can occur even without direct contact, although detailed knowledge of airborne routes and other indirect transmission paths is still lacking. Ground transmission of viruses is also possible via wastewater discharges. While enveloped viruses can contaminate potable water and wastewater through human excretions such as feces and droplets, careless PPE disposal can also lead to their transmission into our environment. This paper also highlights the possibility that viruses can be transmitted into the environment from PPE kits used by healthcare and emergency service personnel. A simulation-based approach was developed to understand the transport mechanism for coronavirus and similar enveloped viruses in the environment through porous media, and preliminary results from this model are presented here. Those results indicate that viruses can move through porous soil and eventually contaminate groundwater. This paper therefore underlines the importance of proper PPE disposal by healthcare workers in the Mediterranean region and around the world.", "doi": "10.1007/s41207-021-00251-w", "pmid": "33842691", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "251"}, {"db": "pmc", "key": "PMC8024444"}], "notes": [], "created": "2021-04-13T09:37:59.682Z", "modified": "2021-04-13T10:15:55.648Z"}, {"entity": "publication", "iuid": "38721962da8b47b7ab73d1b984f6f0e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38721962da8b47b7ab73d1b984f6f0e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38721962da8b47b7ab73d1b984f6f0e8"}}, "title": "Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19", "authors": [{"family": "Klaric", "given": "Lucija", "initials": "L"}, {"family": "Gisby", "given": "Jack S", "initials": "JS"}, {"family": "Papadaki", "given": "Artemis", "initials": "A"}, {"family": "Muckian", "given": "Marisa D", "initials": "MD"}, {"family": "Macdonald-Dunlop", "given": "Erin", "initials": "E"}, {"family": "Zhao", "given": "Jing Hua", "initials": "JH"}, {"family": "Tokolyi", "given": "Alex", "initials": "A"}, {"family": "Persyn", "given": "Elodie", "initials": "E"}, {"family": "Pairo-Castineira", "given": "Erola", "initials": "E"}, {"family": "Morris", "given": "Andrew P", "initials": "AP"}, {"family": "Kalnapenkis", "given": "Anette", "initials": "A"}, {"family": "Richmond", "given": "Anne", "initials": "A"}, {"family": "Landini", "given": "Arianna", "initials": "A"}, {"family": "Hedman", "given": "\u00c5sa K", "initials": "\u00c5K"}, {"family": "Prins", "given": "Bram", "initials": "B"}, {"family": "Zanetti", "given": "Daniela", "initials": "D"}, {"family": "Wheeler", "given": "Eleanor", "initials": "E"}, {"family": "Kooperberg", "given": "Charles", "initials": "C"}, {"family": "Yao", "given": "Chen", "initials": "C"}, {"family": "Petrie", "given": "John R", "initials": "JR"}, {"family": "Fu", "given": "Jingyuan", "initials": "J"}, {"family": "Folkersen", "given": "Lasse", "initials": "L"}, {"family": "Walker", "given": "Mark", "initials": "M"}, {"family": "Magnusson", "given": "Martin", "initials": "M"}, {"family": "Eriksson", "given": "Niclas", "initials": "N"}, {"family": "Mattsson-Carlgren", "given": "Niklas", "initials": "N"}, {"family": "Timmers", "given": "Paul R H J", "initials": "PRHJ"}, {"family": "Hwang", "given": "Shih Jen", "initials": "SJ"}, {"family": "Enroth", "given": "Stefan", "initials": "S"}, {"family": "Gustafsson", "given": "Stefan", "initials": "S"}, {"family": "Vosa", "given": "Urmo", "initials": "U"}, {"family": "Chen", "given": "Yan", "initials": "Y"}, {"family": "Siegbahn", "given": "Agneta", "initials": "A"}, {"family": "Reiner", "given": "Alexander", "initials": "A"}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Thorand", "given": "Barbara", "initials": "B"}, {"family": "Gigante", "given": "Bruna", "initials": "B"}, {"family": "Hayward", "given": "Caroline", "initials": "C"}, {"family": "Herder", "given": "Christian", "initials": "C"}, {"family": "Gieger", "given": "Christian", "initials": "C"}, {"family": "Langenberg", "given": "Claudia", "initials": "C"}, {"family": "Levy", "given": "Daniel", "initials": "D"}, {"family": "Zhernakova", "given": "Daria V", "initials": "DV"}, {"family": "Smith", "given": "J Gustav", "initials": "JG"}, {"family": "Campbell", "given": "Harry", "initials": "H"}, {"family": "Sundstrom", "given": "Johan", "initials": "J"}, {"family": "Danesh", "given": "John", "initials": "J"}, {"family": "Micha\u00eblsson", "given": "Karl", "initials": "K"}, {"family": "Suhre", "given": "Karsten", "initials": "K"}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Wallentin", "given": "Lars", "initials": "L"}, {"family": "Padyukov", "given": "Leonid", "initials": "L"}, {"family": "Land\u00e9n", "given": "Mikael", "initials": "M"}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ"}, {"family": "G\u00f6teson", "given": "Andreas", "initials": "A"}, {"family": "Hansson", "given": "Oskar", "initials": "O"}, {"family": "Eriksson", "given": "Per", "initials": "P"}, {"family": "Strawbridge", "given": "Rona J", "initials": "RJ"}, {"family": "Assimes", "given": "Themistocles L", "initials": "TL"}, {"family": "Esko", "given": "Tonu", "initials": "T"}, {"family": "Gyllensten", "given": "Ulf", "initials": "U"}, {"family": "Baillie", "given": "J Kenneth", "initials": "JK"}, {"family": "Paul", "given": "Dirk S", "initials": "DS"}, {"family": "Joshi", "given": "Peter K", "initials": "PK"}, {"family": "Butterworth", "given": "Adam S", "initials": "AS"}, {"family": "M\u00e4larstig", "given": "Anders", "initials": "A"}, {"family": "Pirastu", "given": "Nicola", "initials": "N"}, {"family": "Wilson", "given": "James F", "initials": "JF"}, {"family": "Peters", "given": "James E", "initials": "JE"}], "type": "posted-content", "published": "2021-04-07", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.01.21254789", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "URL", "key": "https://www.medrxiv.org/node/330092.external-links.html", "description": "All data are available in the paper and supplementary material"}], "notes": [], "created": "2021-04-09T17:20:45.937Z", "modified": "2021-11-18T12:28:05.919Z"}, {"entity": "publication", "iuid": "009ec6accb344739ba8d2b672015151e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/009ec6accb344739ba8d2b672015151e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/009ec6accb344739ba8d2b672015151e"}}, "title": "Impact of COVID-19 on social media as perceived by the oncology community: results from a survey in collaboration with the European Society for Medical Oncology (ESMO) and the OncoAlert Network.", "authors": [{"family": "Morgan", "given": "G", "initials": "G"}, {"family": "Tagliamento", "given": "M", "initials": "M"}, {"family": "Lambertini", "given": "M", "initials": "M"}, {"family": "Devnani", "given": "B", "initials": "B"}, {"family": "Westphalen", "given": "B", "initials": "B"}, {"family": "Dienstmann", "given": "R", "initials": "R"}, {"family": "Bozovic-Spasojevic", "given": "I", "initials": "I"}, {"family": "Calles", "given": "A", "initials": "A"}, {"family": "Criscitiello", "given": "C", "initials": "C"}, {"family": "Curioni", "given": "A", "initials": "A"}, {"family": "Garcia", "given": "A M", "initials": "AM"}, {"family": "Lamarca", "given": "A", "initials": "A"}, {"family": "Pilotto", "given": "S", "initials": "S"}, {"family": "Scheffler", "given": "M", "initials": "M"}, {"family": "Strijbos", "given": "M", "initials": "M"}, {"family": "Wong", "given": "R", "initials": "R"}, {"family": "de Azambuja", "given": "E", "initials": "E"}, {"family": "Peters", "given": "S", "initials": "S"}], "type": "journal article", "published": "2021-04-07", "journal": {"title": "ESMO Open", "issn": "2059-7029", "volume": "6", "issue": "2", "pages": "100104", "issn-l": null}, "abstract": "The COVID-19 pandemic has impacted all aspects of modern-day oncology, including how stakeholders communicate through social media. We surveyed oncology stakeholders in order to assess their attitudes pertaining to social media and how it has been affected during the pandemic.\n\nA 40-item survey was distributed to stakeholders from 8 July to 22 July 2020 and was promoted through the European Society for Medical Oncology (ESMO) and the OncoAlert Network.\n\nOne thousand and seventy-six physicians and stakeholders took part in the survey. In total, 57.3% of respondents were medical oncologists, 50.6% aged <40 years, 50.8% of female gender and mostly practicing in Europe (51.5%). More than 90% of respondents considered social media a useful tool for distributing scientific information and for education. Most used social media to stay up to date on cancer care in general (62.5%) and cancer care during COVID-19 (61%) given the constant flow of information. Respondents also used social media to interact with other oncologists (78.8%) and with patients (34.4%). Overall, 61.1% of respondents were satisfied with the role that social media was playing during the COVID-19 pandemic. On the other hand, 41.1% of respondents reported trouble in discriminating between credible and less credible information and 30% stated social networks were a source of stress. For this reason, one-third of respondents reduced its use during the COVID-19 pandemic. Regarding meeting attendance, a total of 59.1% of responding physicians preferred in-person meetings to virtual ones, and 51.8% agreed that virtual meetings and social distancing could hamper effective collaboration.\n\nSocial media has a useful role in supporting cancer care and professional engagement in oncology. Although one-third of respondents reported reduced use of social media due to stress during the COVID-19 pandemic, the majority found social media useful to keep up to date and were satisfied with the role social media was playing during the pandemic.", "doi": "10.1016/j.esmoop.2021.100104", "pmid": "33838532", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2059-7029(21)00061-2"}], "notes": [], "created": "2021-04-12T15:37:58.350Z", "modified": "2021-04-12T15:37:58.364Z"}, {"entity": "publication", "iuid": "3b2eb5d7df4c423fb1850f747e0c19ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b2eb5d7df4c423fb1850f747e0c19ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b2eb5d7df4c423fb1850f747e0c19ee"}}, "title": "Extracorporeal Membrane Oxygenation in Patients With COVID-19: An International Multicenter Cohort Study.", "authors": [{"family": "Raasveld", "given": "Senta Jorinde", "initials": "SJ"}, {"family": "Delnoij", "given": "Thijs S R", "initials": "TSR"}, {"family": "Broman", "given": "Lars M", "initials": "LM"}, {"family": "Lansink-Hartgring", "given": "Annemieke Oude", "initials": "AO"}, {"family": "Hermans", "given": "Greet", "initials": "G"}, {"family": "De Troy", "given": "Erwin", "initials": "E"}, {"family": "Taccone", "given": "Fabio S", "initials": "FS"}, {"family": "Quintana Diaz", "given": "Manuel", "initials": "M"}, {"family": "van der Velde", "given": "Franciska", "initials": "F"}, {"family": "Miranda", "given": "Dinis Dos Reis", "initials": "DDR"}, {"family": "Scholten", "given": "Erik", "initials": "E"}, {"family": "ETALON Study Group", "given": "", "initials": ""}, {"family": "Vlaar", "given": "Alexander P J", "initials": "APJ"}], "type": "journal article", "published": "2021-04-07", "journal": {"title": "J Intensive Care Med", "issn": "1525-1489", "volume": null, "issue": null, "pages": "8850666211007063", "issn-l": null}, "abstract": "To report and compare the characteristics and outcomes of COVID-19 patients on extracorporeal membrane oxygenation (ECMO) to non-COVID-19 acute respiratory distress syndrome (ARDS) patients on ECMO.\n\nWe performed an international retrospective study of COVID-19 patients on ECMO from 13 intensive care units from March 1 to April 30, 2020. Demographic data, ECMO characteristics and clinical outcomes were collected. The primary outcome was to assess the complication rate and 28-day mortality; the secondary outcome was to compare patient and ECMO characteristics between COVID-19 patients on ECMO and non-COVID-19 related ARDS patients on ECMO (non-COVID-19; January 1, 2018 until July 31, 2019).\n\nDuring the study period 71 COVID-19 patients received ECMO, mostly veno-venous, for a median duration of 13 days (IQR 7-20). ECMO was initiated at 5 days (IQR 3-10) following invasive mechanical ventilation. Median PaO 2/FiO2 ratio prior to initiation of ECMO was similar in COVID-19 patients (58 mmHg [IQR 46-76]) and non-COVID-19 patients (53 mmHg [IQR 44-66]), the latter consisting of 48 patients. 28-day mortality was 37% in COVID-19 patients and 27% in non-COVID-19 patients. However, Kaplan-Meier curves showed that after a 100-day follow-up this non-significant difference resolves. Non-surviving COVID-19 patients were more acidotic prior to initiation ECMO, had a shorter ECMO run and fewer received muscle paralysis compared to survivors.\n\nNo significant differences in outcomes were found between COVID-19 patients on ECMO and non-COVID-19 ARDS patients on ECMO. This suggests that ECMO could be considered as a supportive therapy in case of refractory respiratory failure in COVID-19.", "doi": "10.1177/08850666211007063", "pmid": "33823709", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-09T16:37:56.539Z", "modified": "2021-04-09T16:38:10.777Z"}, {"entity": "publication", "iuid": "3b12c54aa1004277b287b04be74241cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b12c54aa1004277b287b04be74241cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b12c54aa1004277b287b04be74241cf"}}, "title": "Evaluation of 11 SARS-CoV-2 antibody tests by using samples from patients with defined IgG antibody titers.", "authors": [{"family": "Lagerqvist", "given": "Nina", "initials": "N"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Verner-Carlsson", "given": "Jenny", "initials": "J"}, {"family": "Olausson", "given": "Mikaela", "initials": "M"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Wigren Bystr\u00f6m", "given": "Julia", "initials": "J"}, {"family": "Monsen", "given": "Tor", "initials": "T"}, {"family": "Forsell", "given": "Mattias", "initials": "M"}, {"family": "Eriksson", "given": "Jenny", "initials": "J"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Ljunggren", "given": "Joel", "initials": "J"}, {"family": "Repo", "given": "Johanna", "initials": "J"}, {"family": "Kjerstadius", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Muradrasoli", "given": "Shaman", "initials": "S"}, {"family": "Brytting", "given": "Mia", "initials": "M"}, {"family": "Szekely Bj\u00f6rndal", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "\u00c5kerlund", "given": "Thomas", "initials": "T"}, {"family": "Nilsson", "given": "Charlotta", "initials": "C"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2021-04-07", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "7614"}, "abstract": "We evaluated the performance of 11 SARS-CoV-2 antibody tests using a reference set of heat-inactivated samples from 278 unexposed persons and 258 COVID-19 patients, some of whom contributed serial samples. The reference set included samples with a variation in SARS-CoV-2 IgG antibody titers, as determined by an in-house immunofluorescence assay (IFA). The five evaluated rapid diagnostic tests had a specificity of 99.0% and a sensitivity that ranged from 56.3 to 81.6% and decreased with low IFA IgG titers. The specificity was > 99% for five out of six platform-based tests, and when assessed using samples collected \u2265 22 days after symptom onset, two assays had a sensitivity of > 96%. These two assays also detected samples with low IFA titers more frequently than the other assays. In conclusion, the evaluated antibody tests showed a heterogeneity in their performances and only a few tests performed well with samples having low IFA IgG titers, an important aspect for diagnostics and epidemiological investigations.", "doi": "10.1038/s41598-021-87289-6", "pmid": "33828214", "labels": {"Type: Journal article": null, "Category: Other": null, "Funder: VR": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-87289-6"}], "notes": [], "created": "2021-04-09T16:40:58.037Z", "modified": "2021-09-28T13:28:38.352Z"}, {"entity": "publication", "iuid": "524d8edfc6a445d8af1393abeba6c868", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/524d8edfc6a445d8af1393abeba6c868.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/524d8edfc6a445d8af1393abeba6c868"}}, "title": "Uneven growth of SARS-CoV-2 clones evidenced by more than 500,000 whole-genome sequences", "authors": [{"family": "Zeng", "given": "Hong Li", "initials": "HL"}, {"family": "Liu", "given": "Yue", "initials": "Y"}, {"family": "Thorell", "given": "Kaisa", "initials": "K"}, {"family": "Norden", "given": "Rickard", "initials": "R"}, {"family": "Aurell", "given": "Erik", "initials": "E"}], "type": "posted-content", "published": "2021-04-06", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.06.437914", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Genomics & transcriptomics": null}, "xrefs": [], "notes": [], "created": "2021-04-08T18:32:33.788Z", "modified": "2021-04-13T14:01:53.008Z"}, {"entity": "publication", "iuid": "53ae2f2924db4176962ce29761d86697", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53ae2f2924db4176962ce29761d86697.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53ae2f2924db4176962ce29761d86697"}}, "title": "The Up state of the SARS-COV-2 Spike homotrimer favors an increased virulence for new variants", "authors": [{"family": "Giron", "given": "Carolina Corr\u00eaa", "initials": "CC"}, {"family": "Laaksonen", "given": "Aatto", "initials": "A"}, {"family": "da Silva", "given": "Fernando Lu\u00eds Barroso", "initials": "FLB"}], "type": "posted-content", "published": "2021-04-06", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.05.438465", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-08T18:35:24.719Z", "modified": "2021-04-15T18:28:09.307Z"}, {"entity": "publication", "iuid": "a1911234966d4ac7babf41bc2fbfb0b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a1911234966d4ac7babf41bc2fbfb0b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a1911234966d4ac7babf41bc2fbfb0b0"}}, "title": "The Other Side of SARS-CoV-2 Infection: Neurological Sequelae in Patients.", "authors": [{"family": "Alonso-Bellido", "given": "Isabel M", "initials": "IM"}, {"family": "Bachiller", "given": "Sara", "initials": "S"}, {"family": "V\u00e1zquez", "given": "Guillermo", "initials": "G"}, {"family": "Cruz-Hern\u00e1ndez", "given": "Luis", "initials": "L"}, {"family": "Mart\u00ednez", "given": "Emilio", "initials": "E"}, {"family": "Ruiz-Mateos", "given": "Ezequiel", "initials": "E"}, {"family": "Deierborg", "given": "Tomas", "initials": "T"}, {"family": "Venero", "given": "Jos\u00e9 L", "initials": "JL"}, {"family": "Real", "given": "Luis M", "initials": "LM"}, {"family": "Ruiz", "given": "Roc\u00edo", "initials": "R"}], "type": "journal article", "published": "2021-04-06", "journal": {"title": "Front Aging Neurosci", "issn": "1663-4365", "issn-l": null, "volume": "13", "issue": null, "pages": "632673"}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the globe causing coronavirus disease 2019 (COVID-19). Because it affects the respiratory system, common symptoms are cough and breathing difficulties with fever and fatigue. Also, some cases progress to acute respiratory distress syndrome (ARDS). The acute phase of COVID-19 has been also related to nervous system symptoms, including loss of taste and smell as well as encephalitis and cerebrovascular disorders. However, it remains unclear if neurological complications are due to the direct viral infection of the nervous system, or they appear as a consequence of the immune reaction against the virus in patients who presented pre-existing deficits or had a certain detrimental immune response. Importantly, the medium and long-term consequences of the infection by SARS-CoV-2 in the nervous system remain at present unknown. This review article aims to give an overview of the current neurological symptoms associated with COVID-19, as well as attempting to provide an insight beyond the acute affectation.", "doi": "10.3389/fnagi.2021.632673", "pmid": "33889082", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC8055831"}], "notes": [], "created": "2021-04-29T16:10:40.146Z", "modified": "2021-04-29T16:11:31.138Z"}, {"entity": "publication", "iuid": "5898be945cfd4aea99cd1a994bb2ba1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5898be945cfd4aea99cd1a994bb2ba1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5898be945cfd4aea99cd1a994bb2ba1d"}}, "title": "Perceived Effectiveness, Restrictiveness, and Compliance with Containment Measures against the Covid-19 Pandemic: An International Comparative Study in 11 Countries", "authors": [{"family": "Georgieva", "given": "Irina", "initials": "I"}, {"family": "Lantta", "given": "Tella", "initials": "T"}, {"family": "Lickiewicz", "given": "Jakub", "initials": "J"}, {"family": "Pekara", "given": "Jaroslav", "initials": "J"}, {"family": "Wikman", "given": "Sofia", "initials": "S"}, {"family": "Losevi\u010da", "given": "Marina", "initials": "M"}, {"family": "Raveesh", "given": "Bevinahalli", "initials": "B"}, {"family": "Mihai", "given": "Adriana", "initials": "A"}, {"family": "Lepping", "given": "Peter", "initials": "P"}], "type": "journal-article", "published": "2021-04-06", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "7", "pages": "3806"}, "abstract": "National governments took action to delay the transmission of the coronavirus (SARS-CoV-2) by implementing different containment measures. We developed an online survey that included 44 different containment measures. We aimed to assess how effective citizens perceive these measures, which measures are perceived as violation of citizens' personal freedoms, which opinions and demographic factors have an effect on compliance with the measures, and what governments can do to most effectively improve citizens' compliance. The survey was disseminated in 11 countries: UK, Belgium, Netherlands, Bulgaria, Czech Republic, Finland, India, Latvia, Poland, Romania, and Sweden. We acquired 9543 unique responses. Our findings show significant differences across countries in perceived effectiveness, restrictiveness, and compliance. Governments that suffer low levels of trust should put more effort into persuading citizens, especially men, in the effectiveness of the proposed measures. They should provide financial compensation to citizens who have lost their job or income due to the containment measures to improve measure compliance. Policymakers should implement the least restrictive and most effective public health measures first during pandemic emergencies instead of implementing a combination of many restrictive measures, which has the opposite effect on citizens' adherence and undermines human rights.", "doi": "10.3390/ijerph18073806", "pmid": "33917334", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-04-27T15:00:06.043Z", "modified": "2021-06-18T15:51:54.429Z"}, {"entity": "publication", "iuid": "f76c3e11e2094a3db5ca89e4e76dac36", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f76c3e11e2094a3db5ca89e4e76dac36.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f76c3e11e2094a3db5ca89e4e76dac36"}}, "title": "Heparin binding protein in severe COVID-19-A prospective observational cohort study.", "authors": [{"family": "Mellhammar", "given": "Lisa", "initials": "L"}, {"family": "Thelaus", "given": "Louise", "initials": "L"}, {"family": "El\u00e9n", "given": "Sixten", "initials": "S"}, {"family": "Fisher", "given": "Jane", "initials": "J"}, {"family": "Linder", "given": "Adam", "initials": "A"}], "type": "journal article", "published": "2021-04-06", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "4", "pages": "e0249570", "issn-l": "1932-6203"}, "abstract": "Neutrophil-derived heparin binding protein (HBP; also known as azurocidin or CAP-37) is a key player in bacterial sepsis and a promising biomarker in severe infections. The aims of this study were to assess whether HBP is involved in the pathophysiology of COVID-19 and, if so, whether it can be used to predict severe disease preferably using a point-of-care test.\n\nThis was a prospective convenience sample study of biomarkers in patients admitted to Sk\u00e5ne University hospital in Sweden with a confirmed COVID-19 diagnosis. Plasma samples and clinical data were collected within 72h after admission, during hospital stay and at discharge. Plasma HBP concentrations samples were measured both with enzyme-linked immunosorbent assay (ELISA) and with a novel dry immunofluorescence analyzer (Joinstar) point-of-care test.\n\nThirty-five COVID-19 patients were enrolled in the study. Twenty-nine patients had blood samples taken within 72h after admission. We compared the highest HBP value taken within 72h after admission in patients who eventually developed organ dysfunction (n = 23) compared to those who did not (n = 6), and found that HBP was significantly elevated in those who developed organ dysfunction (25.0 ng/mL (interquartile range (IQR) 16.6-48.5) vs 10.6 ng/mL (IQR 4.8-21.7 ng/mL), p = 0.03). Point-of-care test measurements correlated well with ELISA measurements (R = 0.83). HBP measured by the POC device predicted development of COVID-induced organ dysfunction with an AUC of 0.88 (95% confidence interval (CI) 0.70-1.0).\n\nHBP is elevated prior to onset of organ dysfunction in patients with severe COVID-19 using a newly developed point-of-care test and hence HBP could be used in a clinical setting as a prognostic marker in COVID-19.", "doi": "10.1371/journal.pone.0249570", "pmid": "33822821", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-37580"}], "notes": [], "created": "2021-04-07T10:07:36.447Z", "modified": "2021-04-07T10:12:19.156Z"}, {"entity": "publication", "iuid": "45fc1c11b1b34a8590421d35f7cab87a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/45fc1c11b1b34a8590421d35f7cab87a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/45fc1c11b1b34a8590421d35f7cab87a"}}, "title": "Face mask use during the Covid-19 pandemic - the significance of culture and the symbolic meaning of behaviour.", "authors": [{"family": "Timpka", "given": "Toomas", "initials": "T"}, {"family": "Nyce", "given": "James M", "initials": "JM"}], "type": "journal article", "published": "2021-04-06", "journal": {"title": "Ann Epidemiol", "issn": "1873-2585", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "During public emergencies, a door can open on the fundamental elements upon which a society's social order is built. The Covid-19 pandemic has opened such a door in societies worldwide. We outline in this commentary some of these social elements and how they may have influenced face mask use during the early stages of the pandemic. The purpose is to expand the perspective on mechanisms that are relevant to consider in pandemic response planning. Our look at these fundamental elements showed that latent aspects of the dominant culture and various symbolic meanings of behaviours can reduce adherence with public health recommendations if they are overlooked in the strategic health plans. We conclude that when policymakers decide non-pharmacological interventions during pandemics, they should take into account fundamental attitudes and beliefs that may influence population behaviour. This will require paying attention to variations in things like culture and symbolic meanings of behaviour.", "doi": "10.1016/j.annepidem.2021.03.012", "pmid": "33836290", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S1047-2797(21)00056-9"}], "notes": [], "created": "2021-04-12T16:12:11.271Z", "modified": "2022-11-23T09:01:18.488Z"}, {"entity": "publication", "iuid": "4cf20ca7e7dd4720962ed406c5e2c909", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4cf20ca7e7dd4720962ed406c5e2c909.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4cf20ca7e7dd4720962ed406c5e2c909"}}, "title": "In Silico Mining of Terpenes from Red-Sea Invertebrates for SARS-CoV-2 Main Protease (M pro) Inhibitors.", "authors": [{"family": "Ibrahim", "given": "Mahmoud A A", "initials": "MAA"}, {"family": "Abdelrahman", "given": "Alaa H M", "initials": "AHM"}, {"family": "Mohamed", "given": "Tarik A", "initials": "TA"}, {"family": "Atia", "given": "Mohamed A M", "initials": "MAM"}, {"family": "Al-Hammady", "given": "Montaser A M", "initials": "MAM"}, {"family": "Abdeljawaad", "given": "Khlood A A", "initials": "KAA"}, {"family": "Elkady", "given": "Eman M", "initials": "EM"}, {"family": "Moustafa", "given": "Mahmoud F", "initials": "MF"}, {"family": "Alrumaihi", "given": "Faris", "initials": "F"}, {"family": "Allemailem", "given": "Khaled S", "initials": "KS"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}, {"family": "Par\u00e9", "given": "Paul W", "initials": "PW"}, {"family": "Efferth", "given": "Thomas", "initials": "T"}, {"family": "Hegazy", "given": "Mohamed-Elamir F", "initials": "MF"}], "type": "journal article", "published": "2021-04-05", "journal": {"title": "Molecules", "issn": "1420-3049", "volume": "26", "issue": "7", "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for the COVID-19 pandemic, which generated more than 1.82 million deaths in 2020 alone, in addition to 83.8 million infections. Currently, there is no antiviral medication to treat COVID-19. In the search for drug leads, marine-derived metabolites are reported here as prospective SARS-CoV-2 inhibitors. Two hundred and twenty-seven terpene natural products isolated from the biodiverse Red-Sea ecosystem were screened for inhibitor activity against the SARS-CoV-2 main protease (M pro) using molecular docking and molecular dynamics (MD) simulations combined with molecular mechanics/generalized Born surface area binding energy calculations. On the basis of in silico analyses, six terpenes demonstrated high potency as Mpro inhibitors with \u0394Gbinding \u2264 -40.0 kcal/mol. The stability and binding affinity of the most potent metabolite, erylosides B, were compared to the human immunodeficiency virus protease inhibitor, lopinavir. Erylosides B showed greater binding affinity towards SARS-CoV-2 Mpro than lopinavir over 100 ns with \u0394Gbinding values of -51.9 vs. -33.6 kcal/mol, respectively. Protein-protein interactions indicate that erylosides B biochemical signaling shares gene components that mediate severe acute respiratory syndrome diseases, including the cytokine- and immune-signaling components BCL2L1, IL2, and PRKC. Pathway enrichment analysis and Boolean network modeling were performed towards a deep dissection and mining of the erylosides B target-function interactions. The current study identifies erylosides B as a promising anti-COVID-19 drug lead that warrants further in vitro and in vivo testing.", "doi": "10.3390/molecules26072082", "pmid": "33916461", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "molecules26072082"}, {"db": "pmc", "key": "PMC8038614"}, {"db": "NCBI", "key": "NC_045512.2", "description": "Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, complete genome"}], "notes": [], "created": "2021-05-04T16:27:49.783Z", "modified": "2021-11-18T09:05:18.572Z"}, {"entity": "publication", "iuid": "317a13989d5e43c78a5e660bf9a2adb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/317a13989d5e43c78a5e660bf9a2adb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/317a13989d5e43c78a5e660bf9a2adb1"}}, "title": "Implementation of the COVID-19 Vulnerability Index Across an International Network of Health Care Data Sets: Collaborative External Validation Study.", "authors": [{"family": "Reps", "given": "Jenna M", "initials": "JM", "orcid": "0000-0002-2970-0778", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/135caa88779346ac97e682edad7b6805.json"}}, {"family": "Kim", "given": "Chungsoo", "initials": "C", "orcid": "0000-0003-1802-1777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/19d957a32f3a4830b7e5937eb17ab595.json"}}, {"family": "Williams", "given": "Ross D", "initials": "RD", "orcid": "0000-0001-7723-417X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0392fa0097654386b5afb53621736a2b.json"}}, {"family": "Markus", "given": "Aniek F", "initials": "AF", "orcid": "0000-0001-5779-4794", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9266586bbfd54362bd837362d99e6f98.json"}}, {"family": "Yang", "given": "Cynthia", "initials": "C", "orcid": "0000-0001-6769-3153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1492941467c846b8a87f70a8f007de80.json"}}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T", "orcid": "0000-0002-8274-0357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11fd8deb257445e7a93a0a3098b246df.json"}}, {"family": "Falconer", "given": "Thomas", "initials": "T", "orcid": "0000-0001-6904-1394", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39f9b217653b4b3d8ad2b4ce30d1ca80.json"}}, {"family": "Jonnagaddala", "given": "Jitendra", "initials": "J", "orcid": "0000-0002-9912-2344", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8403290b9ec43fe93b558de97d84559.json"}}, {"family": "Williams", "given": "Andrew", "initials": "A", "orcid": "0000-0002-0692-412X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/287d6018570d44588277109d7fb7e705.json"}}, {"family": "Fern\u00e1ndez-Bertol\u00edn", "given": "Sergio", "initials": "S", "orcid": "0000-0002-0029-6564", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d21eaa376144a42be9422fb45441fb4.json"}}, {"family": "DuVall", "given": "Scott L", "initials": "SL", "orcid": "0000-0002-4898-3865", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bd524264c46548cf861123d43d57151a.json"}}, {"family": "Kostka", "given": "Kristin", "initials": "K", "orcid": "0000-0003-2595-8736", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9675cf1b775341f6a3521c7dde950262.json"}}, {"family": "Rao", "given": "Gowtham", "initials": "G", "orcid": "0000-0002-4949-7236", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2ed658710d4a5eb53b4b0da495b6b4.json"}}, {"family": "Shoaibi", "given": "Azza", "initials": "A", "orcid": "0000-0002-6976-2594", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58deef993a4e4e008923f454d8617b61.json"}}, {"family": "Ostropolets", "given": "Anna", "initials": "A", "orcid": "0000-0002-0847-6682", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3f642e577d2445a3a7ce873b42d0c479.json"}}, {"family": "Spotnitz", "given": "Matthew E", "initials": "ME", "orcid": "0000-0003-2869-0237", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d85f7c654b554b66b57eea3c47b33468.json"}}, {"family": "Zhang", "given": "Lin", "initials": "L", "orcid": "0000-0002-2064-8440", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b787b06f236743559ac8b09000d66ace.json"}}, {"family": "Casajust", "given": "Paula", "initials": "P", "orcid": "0000-0003-2733-5436", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8a3feb959bd461c8c4ad81fcd9dee8b.json"}}, {"family": "Steyerberg", "given": "Ewout W", "initials": "EW", "orcid": "0000-0002-7787-0122", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f248f68b4e144348a1969407863dadb8.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a49d17d56f8e458bb4551f374bd6ebf1.json"}}, {"family": "Kaas-Hansen", "given": "Benjamin Skov", "initials": "BS", "orcid": "0000-0003-1023-0371", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2365fe9468204435b0bb04abc7edface.json"}}, {"family": "Choi", "given": "Young Hwa", "initials": "YH", "orcid": "0000-0001-5254-3101", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e99fc02a7e45f197e6d745bb214e9c.json"}}, {"family": "Morales", "given": "Daniel", "initials": "D", "orcid": "0000-0002-0063-8069", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2db57e8786f41168f4a59dcab7086c3.json"}}, {"family": "Liaw", "given": "Siaw-Teng", "initials": "ST", "orcid": "0000-0001-5989-3614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aacd21dc33904474aa9239d5da644a84.json"}}, {"family": "Abrah\u00e3o", "given": "Maria Tereza Fernandes", "initials": "MTF", "orcid": "0000-0003-2701-670X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/725376c88fe14c138abace2cb37170b4.json"}}, {"family": "Areia", "given": "Carlos", "initials": "C", "orcid": "0000-0002-4668-7069", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7232f54be5df43f0b984d0117d88a054.json"}}, {"family": "Matheny", "given": "Michael E", "initials": "ME", "orcid": "0000-0003-3217-4147", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75cbaa15413a4673ae9037f58cc9a314.json"}}, {"family": "Lynch", "given": "Kristine E", "initials": "KE", "orcid": "0000-0002-2221-2421", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fdab158b00984381b1379ab876c1e09f.json"}}, {"family": "Arag\u00f3n", "given": "Mar\u00eda", "initials": "M", "orcid": "0000-0002-5990-6953", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d7030a55a3e84c36ad06f405dc1f9d68.json"}}, {"family": "Park", "given": "Rae Woong", "initials": "RW", "orcid": "0000-0003-4989-3287", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8974a9e22f940d7939f0bec7810c9c6.json"}}, {"family": "Hripcsak", "given": "George", "initials": "G", "orcid": "0000-0003-2664-7614", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93e21b1266964d22b49cdafdd03caa7d.json"}}, {"family": "Reich", "given": "Christian G", "initials": "CG", "orcid": "0000-0002-3641-055X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6982fa4f228643c6bac91609a0b336d3.json"}}, {"family": "Suchard", "given": "Marc A", "initials": "MA", "orcid": "0000-0001-9818-479X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4f920e0e55c94e91b4dcff796bd24246.json"}}, {"family": "You", "given": "Seng Chan", "initials": "SC", "orcid": "0000-0002-5052-6399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4be7ad3cc7c6440b9f628d7bcedc8a6a.json"}}, {"family": "Ryan", "given": "Patrick B", "initials": "PB", "orcid": "0000-0002-9727-2138", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7f5f6d8b6bb4d85b1430cda6aea55b8.json"}}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D", "orcid": "0000-0002-3950-6346", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1c3f99e11244a3b90ba881356d3e259.json"}}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR", "orcid": "0000-0003-0621-1979", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d03ea51cfd6344d5a6469fef31e9f941.json"}}], "type": "journal article", "published": "2021-04-05", "journal": {"title": "JMIR Med Inform", "issn": "2291-9694", "issn-l": null, "volume": "9", "issue": "4", "pages": "e21547"}, "abstract": "SARS-CoV-2 is straining health care systems globally. The burden on hospitals during the pandemic could be reduced by implementing prediction models that can discriminate patients who require hospitalization from those who do not. The COVID-19 vulnerability (C-19) index, a model that predicts which patients will be admitted to hospital for treatment of pneumonia or pneumonia proxies, has been developed and proposed as a valuable tool for decision-making during the pandemic. However, the model is at high risk of bias according to the \"prediction model risk of bias assessment\" criteria, and it has not been externally validated.\n\nThe aim of this study was to externally validate the C-19 index across a range of health care settings to determine how well it broadly predicts hospitalization due to pneumonia in COVID-19 cases.\n\nWe followed the Observational Health Data Sciences and Informatics (OHDSI) framework for external validation to assess the reliability of the C-19 index. We evaluated the model on two different target populations, 41,381 patients who presented with SARS-CoV-2 at an outpatient or emergency department visit and 9,429,285 patients who presented with influenza or related symptoms during an outpatient or emergency department visit, to predict their risk of hospitalization with pneumonia during the following 0-30 days. In total, we validated the model across a network of 14 databases spanning the United States, Europe, Australia, and Asia.\n\nThe internal validation performance of the C-19 index had a C statistic of 0.73, and the calibration was not reported by the authors. When we externally validated it by transporting it to SARS-CoV-2 data, the model obtained C statistics of 0.36, 0.53 (0.473-0.584) and 0.56 (0.488-0.636) on Spanish, US, and South Korean data sets, respectively. The calibration was poor, with the model underestimating risk. When validated on 12 data sets containing influenza patients across the OHDSI network, the C statistics ranged between 0.40 and 0.68.\n\nOur results show that the discriminative performance of the C-19 index model is low for influenza cohorts and even worse among patients with COVID-19 in the United States, Spain, and South Korea. These results suggest that C-19 should not be used to aid decision-making during the COVID-19 pandemic. Our findings highlight the importance of performing external validation across a range of settings, especially when a prediction model is being extrapolated to a different population. In the field of prediction, extensive validation is required to create appropriate trust in a model.", "doi": "10.2196/21547", "pmid": "33661754", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8023380"}, {"db": "pii", "key": "v9i4e21547"}], "notes": [], "created": "2021-11-15T06:53:48.925Z", "modified": "2023-06-19T15:02:21.240Z"}, {"entity": "publication", "iuid": "42c6f5159867443ba26ed8b54fdc4294", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/42c6f5159867443ba26ed8b54fdc4294.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/42c6f5159867443ba26ed8b54fdc4294"}}, "title": "Driving potent neutralization of a SARS-CoV-2 Variant of Concern with a heterotypic boost", "authors": [{"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Mandolesi", "given": "Marco", "initials": "M"}, {"family": "Kim", "given": "Changil", "initials": "C"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Vidakovics", "given": "Laura Perez", "initials": "LP"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Hedestam", "given": "Gunilla B Karlsson", "initials": "GBK"}, {"family": "Murrell", "given": "Ben", "initials": "B"}], "type": "posted-content", "published": "2021-04-05", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.03.438330", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Funder: H2020": null, "Funder: VR": null}, "xrefs": [{"db": "URL", "key": "https://github.com/MurrellGroup/VOCfreq", "description": "code to complete analyses and instructions to acquire data"}], "notes": [], "created": "2021-04-08T18:37:21.184Z", "modified": "2021-11-18T11:58:02.091Z"}, {"entity": "publication", "iuid": "513b358e6a614996b03261079249c2d6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/513b358e6a614996b03261079249c2d6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/513b358e6a614996b03261079249c2d6"}}, "title": "COVID-19 vaccination in mastocytosis: recommendations of the European Competence Network on Mastocytosis (ECNM) and American Initiative in Mast Cell Diseases (AIM).", "authors": [{"family": "Bonadonna", "given": "Patrizia", "initials": "P"}, {"family": "Brockow", "given": "Knut", "initials": "K"}, {"family": "Niedoszytko", "given": "Marek", "initials": "M"}, {"family": "Elberink", "given": "Hanneke Oude", "initials": "HO"}, {"family": "Akin", "given": "Cem", "initials": "C"}, {"family": "Nedoszytko", "given": "Boguslaw", "initials": "B"}, {"family": "Butterfield", "given": "Joseph H", "initials": "JH"}, {"family": "Alvarez-Twose", "given": "Ivan", "initials": "I"}, {"family": "Sotlar", "given": "Karl", "initials": "K"}, {"family": "Schwaab", "given": "Juliana", "initials": "J"}, {"family": "Jawhar", "given": "Mohamad", "initials": "M"}, {"family": "Castells", "given": "Mariana", "initials": "M"}, {"family": "Sperr", "given": "Wolfgang R", "initials": "WR"}, {"family": "Hermine", "given": "Olivier", "initials": "O"}, {"family": "Gotlib", "given": "Jason", "initials": "J"}, {"family": "Zanotti", "given": "Roberta", "initials": "R"}, {"family": "Reiter", "given": "Andreas", "initials": "A"}, {"family": "Broesby-Olsen", "given": "Sigurd", "initials": "S"}, {"family": "Bindslev-Jensen", "given": "Carsten", "initials": "C"}, {"family": "Schwartz", "given": "Lawrence B", "initials": "LB"}, {"family": "Horny", "given": "Hans-Peter", "initials": "HP"}, {"family": "Radia", "given": "Deepti", "initials": "D"}, {"family": "Triggiani", "given": "Massimo", "initials": "M"}, {"family": "Sabato", "given": "Vito", "initials": "V"}, {"family": "Carter", "given": "Melody C", "initials": "MC"}, {"family": "Siebenhaar", "given": "Frank", "initials": "F"}, {"family": "Orfao", "given": "Alberto", "initials": "A"}, {"family": "Grattan", "given": "Clive", "initials": "C"}, {"family": "Metcalfe", "given": "Dean D", "initials": "DD"}, {"family": "Arock", "given": "Michel", "initials": "M"}, {"family": "Gulen", "given": "Theo", "initials": "T"}, {"family": "Hartmann", "given": "Karin", "initials": "K"}, {"family": "Valent", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2021-04-05", "journal": {"title": "J Allergy Clin Immunol Pract", "issn": "2213-2201", "volume": null, "issue": null, "issn-l": null}, "abstract": "Mastocytosis is a neoplasm characterized by an accumulation of mast cells in various organs and increased risk for severe anaphylaxis in patients with concomitant allergies. Covid-19 is a pandemic that is associated with a relatively high rate of severe lung disease and mortality. The mortality is particularly high in those with certain comorbidities and increases with age. Recently, several companies have developed an effective vaccination against Covid-19. Although the reported frequency of severe side effects is low, there is an emerging discussion about the safety of Covid-19 vaccination in patients with severe allergies and mastocytosis. However, even in these patients, severe adverse reactions are rare. We therefore recommend the broad use of Covid-19 vaccination in patients with mastocytosis on a global basis. The only well-established exception is a known or suspected allergy against a constituent of the vaccine. Safety measures, including premedication and post-vaccination observation should be considered in all patients with mastocytosis, depending on the individual personal risk and overall situation in each case. The current article provides a summary of published data, observations and expert opinion that form the basis of these recommendations.", "doi": "10.1016/j.jaip.2021.03.041", "pmid": "33831618", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2213-2198(21)00386-X"}], "notes": [], "created": "2021-04-09T16:46:32.560Z", "modified": "2021-04-23T16:05:54.583Z"}, {"entity": "publication", "iuid": "cec71ba523f3439d9f438153be347ae4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cec71ba523f3439d9f438153be347ae4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cec71ba523f3439d9f438153be347ae4"}}, "title": "COVID-19 research priorities for non-pharmaceutical public health and social measures.", "authors": [{"family": "Semenza", "given": "Jan C", "initials": "JC"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Baka", "given": "Agoritsa", "initials": "A"}, {"family": "Broberg", "given": "Eeva", "initials": "E"}, {"family": "Cenciarelli", "given": "Orlando", "initials": "O"}, {"family": "De Angelis", "given": "Stefania", "initials": "S"}, {"family": "Einoder-Moreno", "given": "Margot", "initials": "M"}, {"family": "Dalmau", "given": "Irina Jovel Quinonez", "initials": "IJQ"}, {"family": "Kinross", "given": "Pete", "initials": "P"}, {"family": "Kinsman", "given": "John", "initials": "J"}, {"family": "Leitmeyer", "given": "Katrin", "initials": "K"}, {"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "Needham", "given": "Howard", "initials": "H"}, {"family": "Plachouras", "given": "Diamantis", "initials": "D"}, {"family": "Robesyn", "given": "Emmanuel", "initials": "E"}, {"family": "Rosales-Klintz", "given": "Senia", "initials": "S"}, {"family": "Suk", "given": "Jonathan E", "initials": "JE"}, {"family": "Suetens", "given": "Carl", "initials": "C"}, {"family": "Weist", "given": "Klaus", "initials": "K"}, {"family": "W\u00fcrz", "given": "Andrea", "initials": "A"}, {"family": "Penttinen", "given": "Pasi", "initials": "P"}], "type": "journal article", "published": "2021-04-05", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": null, "issue": null, "pages": "1-12", "issn-l": null}, "abstract": null, "doi": "10.1017/S0950268821000716", "pmid": "33818348", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0950268821000716"}], "notes": [], "created": "2021-04-06T10:04:18.839Z", "modified": "2021-04-06T10:04:18.848Z"}, {"entity": "publication", "iuid": "3c9d39c1019b430086cd725b0aff2ad5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3c9d39c1019b430086cd725b0aff2ad5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3c9d39c1019b430086cd725b0aff2ad5"}}, "title": "COVID-19: A novel burden on the fragile health system of Angola.", "authors": [{"family": "Gyeltshen", "given": "Dawa", "initials": "D"}, {"family": "Musa", "given": "Shuaibu Saidu", "initials": "SS"}, {"family": "Amesho", "given": "Josephine Ndapewoshali", "initials": "JN"}, {"family": "Ewelike", "given": "Samuel Chukwuebuka", "initials": "SC"}, {"family": "Bayoh", "given": "Alex Vandy Saffa", "initials": "AVS"}, {"family": "Al-Sammour", "given": "Christophe", "initials": "C"}, {"family": "Camua", "given": "Angel Anthony", "initials": "AA"}, {"family": "Lin", "given": "Xu", "initials": "X"}, {"family": "Lowe", "given": "Mat", "initials": "M"}, {"family": "Ahmadi", "given": "Attaullah", "initials": "A"}, {"family": "Ntacyabukura", "given": "Blaise", "initials": "B"}, {"family": "Adebisi", "given": "Yusuff Adebayo", "initials": "YA"}, {"family": "Lucero-Prisno", "given": "Don Eliseo", "initials": "DE"}], "type": "journal article", "published": "2021-04-03", "journal": {"title": "J Glob Health", "issn": "2047-2986", "volume": "11", "issue": null, "pages": "03059", "issn-l": "2047-2978"}, "abstract": null, "doi": "10.7189/jogh.11.03059", "pmid": "33828839", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jogh-11-03059"}, {"db": "pmc", "key": "PMC8021071"}], "notes": [], "created": "2021-04-09T16:43:53.499Z", "modified": "2021-04-09T16:44:17.395Z"}, {"entity": "publication", "iuid": "d8ee3c70a18b4950b58b8cc0d0a44279", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d8ee3c70a18b4950b58b8cc0d0a44279.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d8ee3c70a18b4950b58b8cc0d0a44279"}}, "title": "COVID-19 in solid organ transplant recipients: A national cohort study from Sweden.", "authors": [{"family": "S\u00f8fteland", "given": "John Mackay", "initials": "JM"}, {"family": "Friman", "given": "Gustav", "initials": "G"}, {"family": "von Zur-M\u00fchlen", "given": "Bengt", "initials": "B"}, {"family": "Ericzon", "given": "Bo-G\u00f6ran", "initials": "B"}, {"family": "Wallquist", "given": "Carin", "initials": "C"}, {"family": "Karason", "given": "Kristjan", "initials": "K"}, {"family": "Friman", "given": "Vanda", "initials": "V"}, {"family": "Ekelund", "given": "Jan", "initials": "J"}, {"family": "Felldin", "given": "Marie", "initials": "M"}, {"family": "Magnusson", "given": "Jesper", "initials": "J"}, {"family": "Haugen L\u00f6fman", "given": "Ida", "initials": "I"}, {"family": "Schult", "given": "Andreas", "initials": "A"}, {"family": "de Coursey", "given": "Emily", "initials": "E"}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Jacobsson", "given": "Hanna", "initials": "H"}, {"family": "Liljeqvist", "given": "Jan-\u00c5ke", "initials": "J"}, {"family": "Biglarnia", "given": "Ali Reza", "initials": "AR"}, {"family": "Lindn\u00e9r", "given": "Per", "initials": "P"}, {"family": "Oltean", "given": "Mihai", "initials": "M"}], "type": "journal article", "published": "2021-04-03", "journal": {"title": "Am J Transplant", "issn": "1600-6143", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Solid organ transplant (SOT) recipients run a high risk for adverse outcomes from COVID-19, with reported mortality around 19%. We retrospectively reviewed all known Swedish SOT recipients with RT-PCR confirmed COVID-19 between March 1 st and November 20th, 2020 and analyzed patient characteristics, management, and outcome. We identified 230 patients with a median age of 54.0 years (13.2), who were predominantly male (64%). Most patients were hospitalized (64%), but 36% remained outpatients. Age >50 and male sex were among predictors of transition from outpatient to inpatient status. National early warning Score 2 (NEWS2) at presentation was higher in non-survivors. Thirty-day all-cause mortality was 9.6% (15.0% for inpatients), increased with age and BMI, and was higher in men. Renal function decreased during COVID-19 but recovered in most patients. SARS-CoV-2 antibodies were identified in 78% of patients at 1-2 months post-infection. Nucleocapsid-specific antibodies decreased to 38% after 6-7 months, while spike-specific antibody responses were more durable. Seroprevalence in 559 asymptomatic patients was 1.4%. Many patients can be managed on an outpatient basis aided by risk stratification with age, sex, and NEWS2 score. Factors associated with adverse outcomes include older age, male sex, greater BMI, and a higher NEWS2 score.", "doi": "10.1111/ajt.16596", "pmid": "33811777", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-06T10:13:30.721Z", "modified": "2021-04-06T10:13:53.666Z"}, {"entity": "publication", "iuid": "e2b438d13f5e46f5bf03be41bc5f6b15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2b438d13f5e46f5bf03be41bc5f6b15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2b438d13f5e46f5bf03be41bc5f6b15"}}, "title": "A mediating role for mental health in associations between COVID-19-related self-stigma, PTSD, quality of life, and insomnia among patients recovered from COVID-19.", "authors": [{"family": "Mahmoudi", "given": "Hosein", "initials": "H"}, {"family": "Saffari", "given": "Mohsen", "initials": "M"}, {"family": "Movahedi", "given": "Mahmoud", "initials": "M"}, {"family": "Sanaeinasab", "given": "Hormoz", "initials": "H"}, {"family": "Rashidi-Jahan", "given": "Hojat", "initials": "H"}, {"family": "Pourgholami", "given": "Morteza", "initials": "M"}, {"family": "Poorebrahim", "given": "Ali", "initials": "A"}, {"family": "Barshan", "given": "Jalal", "initials": "J"}, {"family": "Ghiami", "given": "Milad", "initials": "M"}, {"family": "Khoshmanesh", "given": "Saman", "initials": "S"}, {"family": "Potenza", "given": "Marc N", "initials": "MN"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-04-03", "journal": {"title": "Brain Behav", "issn": "2162-3279", "issn-l": null, "volume": null, "issue": null, "pages": "e02138"}, "abstract": "Patients with COVID-19 often suffer from psychological problems such as post-traumatic stress disorder (PTSD) and self-stigmatization that may negatively impact their quality of life and sleep. This study examined mental health as a potential mediating factor linking self-stigmatization and PTSD to quality of life and sleep.\r\n\r\nUsing a cross-sectional design, 844 people who had recovered from COVID-19 were called and interviewed. Data were collected using structured scales. Structural equation modeling was applied to assess fitness of a mediation model including self-stigma and PTSD as independent factors and quality of life and insomnia as dependent variables.\r\n\r\nMental health, COVID-19-related self-stigma, and mental quality of life were associated. Insomnia, PTSD, and COVID-19-related self-stigma displayed significant direct associations (r = .334 to 0.454; p < .01). A mediation model indicated satisfactory goodness of fit (CFI = 0.968, TLI = 0.950, SRMR = 0.071, RMSEA = 0.068). Mental health as a mediator had negative relationships with COVID-19-related self-stigma, PTSD, and insomnia and positive associations with quality of life.\r\n\r\nMental health may mediate effects of COVID-19-related self-stigma and PTSD on quality of life and insomnia. Designing programs to improve mental health among patients with COVID-19 may include efforts to reduce negative effects of PTSD and COVID-19-related self-stigma on quality of life and insomnia.", "doi": "10.1002/brb3.2138", "pmid": "33811451", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-04-06T10:14:42.317Z", "modified": "2021-06-18T15:50:55.477Z"}, {"entity": "publication", "iuid": "38fb2ecbee504f5b8f2376f0b9fee004", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38fb2ecbee504f5b8f2376f0b9fee004.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38fb2ecbee504f5b8f2376f0b9fee004"}}, "title": "Vaccines and Allergic reactions: the past, the current COVID-19 pandemic, and future perspectives.", "authors": [{"family": "Sampath", "given": "Vanitha", "initials": "V"}, {"family": "Rabinowitz", "given": "Grace", "initials": "G"}, {"family": "Shah", "given": "Mihir", "initials": "M"}, {"family": "Jain", "given": "Surabhi", "initials": "S"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}, {"family": "Jesenak", "given": "Milos", "initials": "M"}, {"family": "Rabin", "given": "Ronald", "initials": "R"}, {"family": "Vieths", "given": "Stefan", "initials": "S"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Akdis", "given": "M\u00fcbeccel", "initials": "M"}, {"family": "Barber", "given": "Domingo", "initials": "D"}, {"family": "Breiteneder", "given": "Heimo", "initials": "H"}, {"family": "Chinthrajah", "given": "Sharon", "initials": "S"}, {"family": "Chivato", "given": "Tomas", "initials": "T"}, {"family": "Collins", "given": "William", "initials": "W"}, {"family": "Eiwegger", "given": "Thomas", "initials": "T"}, {"family": "Fast", "given": "Katherine", "initials": "K"}, {"family": "Fokkens", "given": "Wytske", "initials": "W"}, {"family": "O'Hehir", "given": "Robyn E", "initials": "RE"}, {"family": "Ollert", "given": "Markus", "initials": "M"}, {"family": "O'Mahony", "given": "Liam", "initials": "L"}, {"family": "Palomares", "given": "Oscar", "initials": "O"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Riggioni", "given": "Carmen", "initials": "C"}, {"family": "Shamji", "given": "Mohamed H", "initials": "MH"}, {"family": "Sokolowska", "given": "Milena", "initials": "M"}, {"family": "Torres", "given": "Maria Jose", "initials": "MJ"}, {"family": "Traidl-Hoffmann", "given": "Claudia", "initials": "C"}, {"family": "van Zelm", "given": "Menno", "initials": "M"}, {"family": "Wang", "given": "De Yun", "initials": "Y"}, {"family": "Zhang", "given": "Luo", "initials": "L"}, {"family": "Akdis", "given": "CezmiA", "initials": "C"}, {"family": "Nadeau", "given": "Kari C", "initials": "KC"}], "type": "journal article", "published": "2021-04-02", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": null, "issue": null, "issn-l": "0105-4538"}, "abstract": "Vaccines are essential public health tools with a favorable safety profile and prophylactic effectiveness that have historically played significant roles in reducing infectious disease burden in populations, when the majority of individuals are vaccinated. The COVID-19 vaccines are expected to have similar positive impacts on health across the globe. While serious allergic reactions to vaccines are rare, their underlying mechanisms and implications for clinical management should be considered to provide individuals with the safest care possible. In this review, we provide an overview of different types of allergic adverse reactions that can potentially occur aftervaccination and individual vaccine components capable of causing the allergic adverse reactions. We present the incidence of allergic adverse reactions during clinical studies and through post-authorization and post-marketing surveillance and provide plausible causes of these reactions based on potential allergenic components present in several common vaccines. Additionally, we review implications for individual diagnosis and management and vaccine manufacturing overall. Finally, we suggest areas for future research.", "doi": "10.1111/all.14840", "pmid": "33811364", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-04-06T10:17:59.817Z", "modified": "2021-04-23T16:06:21.995Z"}, {"entity": "publication", "iuid": "e24ad035f5844436a6bb40be8e35a395", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e24ad035f5844436a6bb40be8e35a395.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e24ad035f5844436a6bb40be8e35a395"}}, "title": "Stealth Fluorescence Labeling for Live Microscopy Imaging of mRNA Delivery.", "authors": [{"family": "Baladi", "given": "Tom", "initials": "T"}, {"family": "Nilsson", "given": "Jesper R", "initials": "JR"}, {"family": "Gallud", "given": "Audrey", "initials": "A"}, {"family": "Celauro", "given": "Emanuele", "initials": "E"}, {"family": "Gasse", "given": "C\u00e9cile", "initials": "C"}, {"family": "Levi-Acobas", "given": "Fabienne", "initials": "F"}, {"family": "Sarac", "given": "Ivo", "initials": "I"}, {"family": "Hollenstein", "given": "Marcel R", "initials": "MR"}, {"family": "Dahl\u00e9n", "given": "Anders", "initials": "A"}, {"family": "Esbj\u00f6rner", "given": "Elin K", "initials": "EK"}, {"family": "Wilhelmsson", "given": "L Marcus", "initials": "LM"}], "type": "journal article", "published": "2021-04-02", "journal": {"title": "J Am Chem Soc", "issn": "1520-5126", "volume": null, "issue": null, "issn-l": null}, "abstract": "Methods for tracking RNA inside living cells without perturbing their natural interactions and functions are critical within biology and, in particular, to facilitate studies of therapeutic RNA delivery. We present a stealth labeling approach that can efficiently, and with high fidelity, generate RNA transcripts, through enzymatic incorporation of the triphosphate of tC O, a fluorescent tricyclic cytosine analogue. We demonstrate this by incorporation of tCO in up to 100% of the natural cytosine positions of a 1.2 kb mRNA encoding for the histone H2B fused to GFP (H2B:GFP). Spectroscopic characterization of this mRNA shows that the incorporation rate of tCO is similar to cytosine, which allows for efficient labeling and controlled tuning of labeling ratios for different applications. Using live cell confocal microscopy and flow cytometry, we show that the tCO-labeled mRNA is efficiently translated into H2B:GFP inside human cells. Hence, we not only develop the use of fluorescent base analogue labeling of nucleic acids in live-cell microscopy but also, importantly, show that the resulting transcript is translated into the correct protein. Moreover, the spectral properties of our transcripts and their translation product allow for their straightforward, simultaneous visualization in live cells. Finally, we find that chemically transfected tCO-labeled RNA, unlike a state-of-the-art fluorescently labeled RNA, gives rise to expression of a similar amount of protein as its natural counterpart, hence representing a methodology for studying natural, unperturbed processing of mRNA used in RNA therapeutics and in vaccines, like the ones developed against SARS-CoV-2.", "doi": "10.1021/jacs.1c00014", "pmid": "33797236", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-06T10:41:47.769Z", "modified": "2021-04-06T10:41:47.794Z"}, {"entity": "publication", "iuid": "cda6c30f70f24141b31a4e3611da36b6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cda6c30f70f24141b31a4e3611da36b6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cda6c30f70f24141b31a4e3611da36b6"}}, "title": "Management of anaphylaxis due to COVID-19 vaccines in the elderly.", "authors": [{"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Blain", "given": "Hubert", "initials": "H"}, {"family": "Jutel", "given": "Marek", "initials": "M"}, {"family": "Ventura", "given": "Maria Teresa", "initials": "MT"}, {"family": "Worm", "given": "Margitta", "initials": "M"}, {"family": "Del Giacco", "given": "Stefano", "initials": "S"}, {"family": "Benetos", "given": "Athanasios", "initials": "A"}, {"family": "Bilo", "given": "M Beatrice", "initials": "MB"}, {"family": "Czarlewski", "given": "Wienczyslawa", "initials": "W"}, {"family": "Abdul Latiff", "given": "Amir Hamzah", "initials": "AH"}, {"family": "Al-Ahmad", "given": "Mona", "initials": "M"}, {"family": "Angier", "given": "Elizabeth", "initials": "E"}, {"family": "Annesi-Maesano", "given": "Isabella", "initials": "I"}, {"family": "Atanaskovic-Markovic", "given": "Marina", "initials": "M"}, {"family": "Bachert", "given": "Claus", "initials": "C"}, {"family": "Barbaud", "given": "Annick", "initials": "A"}, {"family": "Bedbrook", "given": "Anna", "initials": "A"}, {"family": "Bennoor", "given": "Kazi S", "initials": "KS"}, {"family": "Berghea", "given": "Elena Camelia", "initials": "EC"}, {"family": "Bindslev-Jensen", "given": "Carsten", "initials": "C"}, {"family": "Bonini", "given": "Sergio", "initials": "S"}, {"family": "Bosnic-Anticevich", "given": "Sinthia", "initials": "S"}, {"family": "Brockow", "given": "Knut", "initials": "K"}, {"family": "Brussino", "given": "Luisa", "initials": "L"}, {"family": "Camargos", "given": "Paulo", "initials": "P"}, {"family": "Canonica", "given": "G Walter", "initials": "GW"}, {"family": "Cardona", "given": "Victoria", "initials": "V"}, {"family": "Carreiro-Martins", "given": "Pedro", "initials": "P"}, {"family": "Carriazo", "given": "Ana", "initials": "A"}, {"family": "Casale", "given": "Thomas", "initials": "T"}, {"family": "Caubet", "given": "Jean-Christoph", "initials": "JC"}, {"family": "Cecchi", "given": "Lorenzo", "initials": "L"}, {"family": "Cherubini", "given": "Antonio", "initials": "A"}, {"family": "Christoff", "given": "George", "initials": "G"}, {"family": "Chu", "given": "Derek K", "initials": "DK"}, {"family": "Cruz", "given": "Alvaro A", "initials": "AA"}, {"family": "Dokic", "given": "Dejan", "initials": "D"}, {"family": "El-Gamal", "given": "Yehia", "initials": "Y"}, {"family": "Ebisawa", "given": "Motohiro", "initials": "M"}, {"family": "Eberlein", "given": "Bernadette", "initials": "B"}, {"family": "Farrell", "given": "John", "initials": "J"}, {"family": "Fernandez-Rivas", "given": "Montserrat", "initials": "M"}, {"family": "Fokkens", "given": "Wytske J", "initials": "WJ"}, {"family": "Fonseca", "given": "Joao A", "initials": "JA"}, {"family": "Gao", "given": "Yadong", "initials": "Y"}, {"family": "Gavazzi", "given": "Ga\u00ebtan", "initials": "G"}, {"family": "Gawlik", "given": "Radolslaw", "initials": "R"}, {"family": "Gelincik", "given": "Asli", "initials": "A"}, {"family": "Gemicio\u011flu", "given": "Bilun", "initials": "B"}, {"family": "Gotua", "given": "Maia", "initials": "M"}, {"family": "Gu\u00e9rin", "given": "Olivier", "initials": "O"}, {"family": "Haahtela", "given": "Tari", "initials": "T"}, {"family": "Hoffmann-Sommergruber", "given": "Karin", "initials": "K"}, {"family": "Hoffmann", "given": "Hans J\u00fcrgen", "initials": "HJ"}, {"family": "Hofmann", "given": "Maja", "initials": "M"}, {"family": "Hrubisko", "given": "Martin", "initials": "M"}, {"family": "lenaIllario", "given": "Madda", "initials": "M"}, {"family": "Irani", "given": "Carla", "initials": "C"}, {"family": "Ispayeva", "given": "Zhanat", "initials": "Z"}, {"family": "Ivancevich", "given": "Juan Carlos", "initials": "JC"}, {"family": "Julge", "given": "Kaja", "initials": "K"}, {"family": "Kaidashev", "given": "Igor", "initials": "I"}, {"family": "Khaitov", "given": "Musa", "initials": "M"}, {"family": "Knol", "given": "Edward", "initials": "E"}, {"family": "Kraxner", "given": "Helga", "initials": "H"}, {"family": "Kuna", "given": "Piotr", "initials": "P"}, {"family": "Kvedariene", "given": "Violeta", "initials": "V"}, {"family": "Lauerma", "given": "Antti", "initials": "A"}, {"family": "Le", "given": "Lan Tt", "initials": "LT"}, {"family": "Le Moing", "given": "Vincent", "initials": "V"}, {"family": "Levin", "given": "Michael", "initials": "M"}, {"family": "Louis", "given": "Renaud", "initials": "R"}, {"family": "Lourenco", "given": "Olga", "initials": "O"}, {"family": "Mahler", "given": "Vera", "initials": "V"}, {"family": "Martin", "given": "Finbarr C", "initials": "FC"}, {"family": "Matucci", "given": "Andrea", "initials": "A"}, {"family": "Milenkovic", "given": "Branislava", "initials": "B"}, {"family": "Miot", "given": "St\u00e9phanie", "initials": "S"}, {"family": "Montella", "given": "Emma", "initials": "E"}, {"family": "Morais-Almeida", "given": "Mario", "initials": "M"}, {"family": "Mortz", "given": "Charlotte G", "initials": "CG"}, {"family": "Mullol", "given": "Joaquim", "initials": "J"}, {"family": "Namazova-Baranova", "given": "Leyla", "initials": "L"}, {"family": "Neffen", "given": "Hugo", "initials": "H"}, {"family": "Nekam", "given": "Kristof", "initials": "K"}, {"family": "Niedoszytko", "given": "Marek", "initials": "M"}, {"family": "Odemyr", "given": "Mika\u00ebla", "initials": "M"}, {"family": "O'Hehir", "given": "Robyn E", "initials": "RE"}, {"family": "Okamoto", "given": "Yoshitaka", "initials": "Y"}, {"family": "Ollert", "given": "Markus", "initials": "M"}, {"family": "Palomares", "given": "Oscar", "initials": "O"}, {"family": "Papadopoulos", "given": "Nikolaos G", "initials": "NG"}, {"family": "Panzner", "given": "Petr", "initials": "P"}, {"family": "Passalacqua", "given": "Gianni", "initials": "G"}, {"family": "Patella", "given": "Vincenzo", "initials": "V"}, {"family": "Petrovic", "given": "Mirko", "initials": "M"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Pham-Thi", "given": "Nh\u00e2n", "initials": "N"}, {"family": "Plavec", "given": "Davor", "initials": "D"}, {"family": "Popov", "given": "Todor A", "initials": "TA"}, {"family": "Recto", "given": "Marysia T", "initials": "MT"}, {"family": "Regateiro", "given": "Frederico S", "initials": "FS"}, {"family": "Reynes", "given": "Jacques", "initials": "J"}, {"family": "Roller-Winsberger", "given": "Regina E", "initials": "RE"}, {"family": "Rolland", "given": "Yves", "initials": "Y"}, {"family": "Romano", "given": "Antonino", "initials": "A"}, {"family": "Rondon", "given": "Carmen", "initials": "C"}, {"family": "Rottem", "given": "Menachem", "initials": "M"}, {"family": "Rouadi", "given": "Philip W", "initials": "PW"}, {"family": "Salles", "given": "Nathalie", "initials": "N"}, {"family": "Samolinski", "given": "Boleslaw", "initials": "B"}, {"family": "Santos", "given": "Alexandra F", "initials": "AF"}, {"family": "Serpa", "given": "Faradiba Sarquis", "initials": "FS"}, {"family": "Sastre", "given": "Joaquin", "initials": "J"}, {"family": "Schols", "given": "Jos M G A", "initials": "JMGA"}, {"family": "Scichilone", "given": "Nicola", "initials": "N"}, {"family": "Sediva", "given": "Anna", "initials": "A"}, {"family": "Shamji", "given": "Mohamed H", "initials": "MH"}, {"family": "Sheikh", "given": "Aziz", "initials": "A"}, {"family": "Skypala", "given": "Isabel", "initials": "I"}, {"family": "Smolinska", "given": "Sylwia", "initials": "S"}, {"family": "Sokolowska", "given": "Milena", "initials": "M"}, {"family": "Sousa-Pinto", "given": "Bernardo", "initials": "B"}, {"family": "Sova", "given": "Milan", "initials": "M"}, {"family": "Stelmach", "given": "Rafael", "initials": "R"}, {"family": "Sturm", "given": "Gunter", "initials": "G"}, {"family": "Suppli Ulrik", "given": "Charlotte", "initials": "C"}, {"family": "Todo-Bom", "given": "Ana Maria", "initials": "AM"}, {"family": "Toppila-Salmi", "given": "Sanna", "initials": "S"}, {"family": "Tsiligianni", "given": "Ioanna", "initials": "I"}, {"family": "Torres", "given": "Maria", "initials": "M"}, {"family": "Untersmayr", "given": "Eva", "initials": "E"}, {"family": "Urrutia Pereira", "given": "Marilyn", "initials": "M"}, {"family": "Valiulis", "given": "Arunas", "initials": "A"}, {"family": "Vitte", "given": "Joana", "initials": "J"}, {"family": "Vultaggio", "given": "Alessandra", "initials": "A"}, {"family": "Wallace", "given": "Dana", "initials": "D"}, {"family": "Walusiak-Skorupa", "given": "Jolanta", "initials": "J"}, {"family": "Wang", "given": "De-Yun", "initials": "DY"}, {"family": "Waserman", "given": "Susan", "initials": "S"}, {"family": "Yorgancioglu", "given": "Arzu", "initials": "A"}, {"family": "Yusuf", "given": "Osman M", "initials": "OM"}, {"family": "Zernotti", "given": "Mario", "initials": "M"}, {"family": "Zidarn", "given": "Mihaela", "initials": "M"}, {"family": "Chivato", "given": "Tomas", "initials": "T"}, {"family": "Akdis", "given": "Cezmi A", "initials": "CA"}, {"family": "Zuberbier", "given": "Torsten", "initials": "T"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}], "type": "journal article", "published": "2021-04-02", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": null, "issue": null, "issn-l": "0105-4538"}, "abstract": "Older adults, especially men and/or those with diabetes, hypertension and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritised to receive COVID-19 vaccines due to high risk of death. In very rare instances,the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society)Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients.", "doi": "10.1111/all.14838", "pmid": "33811358", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-06T10:15:54.054Z", "modified": "2021-04-06T10:16:15.682Z"}, {"entity": "publication", "iuid": "8082603cfb84438f9809c0b184885fdc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8082603cfb84438f9809c0b184885fdc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8082603cfb84438f9809c0b184885fdc"}}, "title": "Discovery and in-vitro evaluation of potent SARS-CoV-2 entry inhibitors", "authors": [{"family": "Acharya", "given": "Arpan", "initials": "A"}, {"family": "Pandey", "given": "Kabita", "initials": "K"}, {"family": "Thurman", "given": "Michellie", "initials": "M"}, {"family": "Klug", "given": "Elizabeth", "initials": "E"}, {"family": "Trivedi", "given": "Jay", "initials": "J"}, {"family": "Lorson", "given": "Christian L", "initials": "CL"}, {"family": "Singh", "given": "Kamal", "initials": "K"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}], "type": "posted-content", "published": "2021-04-02", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.02.438204", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-08T19:11:49.891Z", "modified": "2021-04-13T14:00:41.357Z"}, {"entity": "publication", "iuid": "ce0079b35926485894db26d862a5b815", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ce0079b35926485894db26d862a5b815.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ce0079b35926485894db26d862a5b815"}}, "title": "Timing of COVID-19 Vaccine in the setting of anti-CD20 Therapy: A Primer for Nephrologists.", "authors": [{"family": "Kant", "given": "Sam", "initials": "S"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Salas", "given": "Antonio", "initials": "A"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Geetha", "given": "Duvuru", "initials": "D"}], "type": "editorial", "published": "2021-04-01", "journal": {"title": "Kidney Int Rep", "issn": "2468-0249", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.ekir.2021.03.876", "pmid": "33821223", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2468-0249(21)01023-8"}, {"db": "pmc", "key": "PMC8012272"}], "notes": [], "created": "2021-04-07T10:09:52.138Z", "modified": "2021-04-07T10:09:52.160Z"}, {"entity": "publication", "iuid": "caaa85e601364323bba233d68338fc43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/caaa85e601364323bba233d68338fc43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/caaa85e601364323bba233d68338fc43"}}, "title": "Recommendations for accurate genotyping of SARS-CoV-2 using amplicon-based sequencing of clinical samples.", "authors": [{"family": "Kubik", "given": "Slawomir", "initials": "S"}, {"family": "Marques", "given": "Ana Claudia", "initials": "AC"}, {"family": "Xing", "given": "Xiaobin", "initials": "X"}, {"family": "Silvery", "given": "Janine", "initials": "J"}, {"family": "Bertelli", "given": "Claire", "initials": "C"}, {"family": "De Maio", "given": "Flavio", "initials": "F"}, {"family": "Pournaras", "given": "Spyros", "initials": "S"}, {"family": "Burr", "given": "Tom", "initials": "T"}, {"family": "Duffourd", "given": "Yannis", "initials": "Y"}, {"family": "Siemens", "given": "Helena", "initials": "H"}, {"family": "Alloui", "given": "Chakib", "initials": "C"}, {"family": "Song", "given": "Lin", "initials": "L"}, {"family": "Wenger", "given": "Yvan", "initials": "Y"}, {"family": "Saitta", "given": "Alexandra", "initials": "A"}, {"family": "Macheret", "given": "Morgane", "initials": "M"}, {"family": "Smith", "given": "Ewan W", "initials": "EW"}, {"family": "Menu", "given": "Philippe", "initials": "P"}, {"family": "Brayer", "given": "Marion", "initials": "M"}, {"family": "Steinmetz", "given": "Lars M", "initials": "LM"}, {"family": "Si-Mohammed", "given": "Ali", "initials": "A"}, {"family": "Chuisseu", "given": "Josiane", "initials": "J"}, {"family": "Stevens", "given": "Richard", "initials": "R"}, {"family": "Constantoulakis", "given": "Pantelis", "initials": "P"}, {"family": "Sali", "given": "Michela", "initials": "M"}, {"family": "Greub", "given": "Gilbert", "initials": "G"}, {"family": "Tiemann", "given": "Carsten", "initials": "C"}, {"family": "Pelechano", "given": "Vicent", "initials": "V"}, {"family": "Willig", "given": "Adrian", "initials": "A"}, {"family": "Xu", "given": "Zhenyu", "initials": "Z"}], "type": "journal article", "published": "2021-04-01", "journal": {"title": "Clin Microbiol Infect", "issn": "1469-0691", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "SARS-CoV-2 genotyping has been instrumental to monitor viral evolution and transmission during the pandemic. The quality of the sequence data obtained from these genotyping efforts depends on several factors, including the quantity/integrity of the input material, the technology as well as laboratory-specific implementation. The current lack of guidelines for SARS-CoV-2 genotyping leads to inclusion of error-containing genome sequences in genomic epidemiology studies. We aimed at establishing clear and broadly applicable recommendations for reliable virus genotyping.\r\n\r\nWe established and used a sequencing data analysis workflow that reliably identifies and removes technical artifacts, which can result in miscalls when using alternative pipelines, to process clinical samples and synthetic viral genomes with an amplicon-based genotyping approach. We evaluated the impact of experimental factors, including viral load and sequencing depth, on correct sequence determination.\r\n\r\nWe found that at least 1000 viral genomes are necessary to confidently detect variants in the SARS-CoV-2 genome at frequencies of 10% or higher. The broad applicability of our recommendations was validated in over 200 clinical samples from six independent laboratories. The genotypes we determined for clinical isolates with sufficient quality cluster by sampling location and period. Our analysis also supports the rise in frequency of 20A.EU1 and 20A.EU2, two recently reported European strains whose dissemination was facilitated by travelling during the summer of 2020.\r\n\r\nWe present much-needed recommendations for reliable determination of SARS-CoV-2 genome sequence and demonstrate their broad applicability in a large cohort of clinical samples.", "doi": "10.1016/j.cmi.2021.03.029", "pmid": "33813118", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(21)00164-6"}, {"db": "URL", "key": "https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(21)00164-6/fulltext#appsec1", "description": "Data generated with clinical samples can be requested using this information (not suitable for public sharing)"}, {"db": "URL", "key": "https://www.ncbi.nlm.nih.gov/bioproject/PRJNA681574/", "description": "Alternative direct link to SRA (accession: PRJNA681574)"}, {"db": "SRA", "key": "PRJNA681574", "description": "Datasets generated with synthetic SARS-CoV-2 genome"}], "notes": [], "created": "2021-04-06T10:07:38.680Z", "modified": "2021-11-18T11:50:20.495Z"}, {"entity": "publication", "iuid": "60195903649d4bde89045ff87647bbd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60195903649d4bde89045ff87647bbd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60195903649d4bde89045ff87647bbd0"}}, "title": "Maintenance of Acute Stroke Care Service During the COVID-19 Pandemic Lockdown.", "authors": [{"family": "Altersberger", "given": "Valerian L", "initials": "VL"}, {"family": "Stolze", "given": "Lotte J", "initials": "LJ"}, {"family": "Heldner", "given": "Mirjam R", "initials": "MR"}, {"family": "Henon", "given": "Hilde", "initials": "H"}, {"family": "Martinez-Majander", "given": "Nicolas", "initials": "N"}, {"family": "Hametner", "given": "Christian", "initials": "C"}, {"family": "Nordanstig", "given": "Annika", "initials": "A"}, {"family": "Zini", "given": "Andrea", "initials": "A"}, {"family": "Nannoni", "given": "Stefania", "initials": "S"}, {"family": "Gon\u00e7alves", "given": "Bruno", "initials": "B"}, {"family": "Nolte", "given": "Christian H", "initials": "CH"}, {"family": "Baumgartner", "given": "Philipp", "initials": "P"}, {"family": "Kastrup", "given": "Andreas", "initials": "A"}, {"family": "Papanagiotou", "given": "Panagiotis", "initials": "P"}, {"family": "K\u00e4gi", "given": "Georg", "initials": "G"}, {"family": "Leker", "given": "Ronen R", "initials": "RR"}, {"family": "Zedde", "given": "Marialuisa", "initials": "M"}, {"family": "Padovani", "given": "Alessandro", "initials": "A"}, {"family": "Pezzini", "given": "Alessandro", "initials": "A"}, {"family": "Padjen", "given": "Visnja", "initials": "V"}, {"family": "Cereda", "given": "Carlo W", "initials": "CW"}, {"family": "Ntaios", "given": "Georges", "initials": "G"}, {"family": "Bonati", "given": "Leo H", "initials": "LH"}, {"family": "Rinkel", "given": "Leon A", "initials": "LA"}, {"family": "Fischer", "given": "Urs", "initials": "U"}, {"family": "Scheitz", "given": "Jan F", "initials": "JF"}, {"family": "Wegener", "given": "Susanne", "initials": "S"}, {"family": "Turc", "given": "Guillaume", "initials": "G"}, {"family": "Michel", "given": "Patrik", "initials": "P"}, {"family": "Gentile", "given": "Mauro", "initials": "M"}, {"family": "Rentzos", "given": "Alexandros", "initials": "A"}, {"family": "Ringleb", "given": "Peter A", "initials": "PA"}, {"family": "Curtze", "given": "Sami", "initials": "S"}, {"family": "Cordonnier", "given": "Charlotte", "initials": "C"}, {"family": "Arnold", "given": "Marcel", "initials": "M"}, {"family": "Nederkoorn", "given": "Paul J", "initials": "PJ"}, {"family": "Engelter", "given": "Stefan T", "initials": "ST"}, {"family": "Gensicke", "given": "Henrik", "initials": "H"}, {"family": "TRISP Collaborators", "given": "", "initials": ""}], "type": "journal article", "published": "2021-04-01", "journal": {"title": "Stroke", "issn": "1524-4628", "volume": null, "issue": null, "pages": "STROKEAHA120032176", "issn-l": null}, "abstract": "Timely reperfusion is an important goal in treatment of eligible patients with acute ischemic stroke. However, during the coronavirus disease 2019 (COVID-19) pandemic, prehospital and in-hospital emergency procedures faced unprecedented challenges, which might have caused a decline in the number of acute reperfusion therapy applied and led to a worsening of key quality measures for this treatment during lockdown.\n\nThis prospective multicenter cohort study used data from the TRISP (Thrombolysis in Ischemic Stroke Patients) registry of patients with acute ischemic stroke treated with reperfusion therapies, that is, intravenous thrombolysis or endovascular therapy. We compared prehospital and in-hospital time-based performance measures (stroke-onset-to-admission, admission-to-treatment, admission-to-image, and image-to-treatment time) during the first 6 weeks after announcement of lockdown (lockdown period) with the same period in 2019 (reference period). Secondary outcomes included stroke severity (National Institutes of Health Stroke Scale) after 24 hours and occurrence of symptomatic intracranial hemorrhage (following the ECASS [European-Australasian Acute Stroke Study]-II criteria).\n\nAcross 20 stroke centers, 540 patients were treated with intravenous thrombolysis/endovascular therapy during lockdown period compared with 578 patients during reference period (-7% [95% CI, 5%-9%]). Performance measures did not change significantly during the lockdown period (2020/2019 minutes median: onset-to-admission 133/145; admission-to-treatment 51/48). Same was true for admission-to-image (20/19) and image-to-treatment (31/30) time in patients with available time of first image (n=871, 77.9%). Median National Institutes of Health Stroke Scale on admission (2020/2019: 11/11) and after 24 hours (2020/2019: 6/5) and percentage of symptomatic intracranial hemorrhage (2020/2019: 6.2/5.7) did not differ significantly between both periods.\n\nThe COVID-19 pandemic lockdown resulted in a mild decline in the number of patients with stroke treated with acute reperfusion therapies. More importantly, the solid stability of key quality performance measures between the 2020 and 2019 period may indicate resilience of acute stroke care service during the lockdown, at least in well-established European stroke centers.", "doi": "10.1161/STROKEAHA.120.032176", "pmid": "33793320", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-06T10:42:44.558Z", "modified": "2021-04-06T10:42:44.569Z"}, {"entity": "publication", "iuid": "d31d1eec18a14cf2a8bd848d0d096265", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d31d1eec18a14cf2a8bd848d0d096265.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d31d1eec18a14cf2a8bd848d0d096265"}}, "title": "Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites", "authors": [{"family": "Hoffmann", "given": "David", "initials": "D"}, {"family": "Mereiter", "given": "Stefan", "initials": "S", "orcid": "0000-0002-4832-3090", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1974c14a7be4583a96ceecccbda4f19.json"}}, {"family": "Oh", "given": "Yoo Jin", "initials": "YJ", "orcid": "0000-0002-9636-3329", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6887c6a78da44881aa30920d96f17d8f.json"}}, {"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Zhu", "given": "Rong", "initials": "R"}, {"family": "Canena", "given": "Daniel", "initials": "D"}, {"family": "Hain", "given": "Lisa", "initials": "L"}, {"family": "Laurent", "given": "Elisabeth", "initials": "E"}, {"family": "Gr\u00fcnwald-Gruber", "given": "Clemens", "initials": "C"}, {"family": "Novatchkova", "given": "Maria", "initials": "M"}, {"family": "Ticevic", "given": "Melita", "initials": "M"}, {"family": "Chabloz", "given": "Antoine", "initials": "A"}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G"}, {"family": "Hagelkruys", "given": "Astrid", "initials": "A"}, {"family": "Altmann", "given": "Friedrich", "initials": "F"}, {"family": "Mach", "given": "Lukas", "initials": "L", "orcid": "0000-0001-9013-5408", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e58ab479be1e4abd9f95f0c5737f280b.json"}}, {"family": "Stadlmann", "given": "Johannes", "initials": "J"}, {"family": "Oostenbrink", "given": "Chris", "initials": "C"}, {"family": "Mirazimi", "given": "Ali", "initials": "A", "orcid": "0000-0003-2371-6055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0651be47429c4e5880a13b839d04fe1d.json"}}, {"family": "Hinterdorfer", "given": "Peter", "initials": "P"}, {"family": "Penninger", "given": "Josef M", "initials": "JM", "orcid": "0000-0002-8194-3777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e56aaa008524272bf252df804e06991.json"}}], "type": "posted-content", "published": "2021-04-01", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.04.01.438087", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-06-09T11:13:03.497Z", "modified": "2021-08-23T14:40:45.988Z"}, {"entity": "publication", "iuid": "5e7d630904214962b1b9fca8e55d053c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e7d630904214962b1b9fca8e55d053c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e7d630904214962b1b9fca8e55d053c"}}, "title": "Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge.", "authors": [{"family": "Winkler", "given": "Martin S", "initials": "MS"}, {"family": "Skirecki", "given": "Tomasz", "initials": "T"}, {"family": "Brunkhorst", "given": "Frank M", "initials": "FM"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "Cavaillon", "given": "Jean-Marc", "initials": "JM"}, {"family": "Ferrer", "given": "Ricard", "initials": "R"}, {"family": "Floh\u00e9", "given": "Stefanie B", "initials": "SB"}, {"family": "Garc\u00eda-Salido", "given": "Alberto", "initials": "A"}, {"family": "Giamarellos-Bourboulis", "given": "Evangelos J", "initials": "EJ"}, {"family": "Girardis", "given": "Massimo", "initials": "M"}, {"family": "Kox", "given": "Matthijs", "initials": "M"}, {"family": "Lachmann", "given": "Gunnar", "initials": "G"}, {"family": "Martin-Loeches", "given": "Ignacio", "initials": "I"}, {"family": "Netea", "given": "Mihai G", "initials": "MG"}, {"family": "Spinetti", "given": "Thibaud", "initials": "T"}, {"family": "Schefold", "given": "Joerg C", "initials": "JC"}, {"family": "Torres", "given": "Antoni", "initials": "A"}, {"family": "Uhle", "given": "Florian", "initials": "F"}, {"family": "Venet", "given": "Fabienne", "initials": "F"}, {"family": "Weis", "given": "Sebastian", "initials": "S"}, {"family": "Scherag", "given": "Andr\u00e9", "initials": "A"}, {"family": "Rubio", "given": "Ignacio", "initials": "I"}, {"family": "Osuchowski", "given": "Marcin F", "initials": "MF"}], "type": "journal article", "published": "2021-04-01", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "volume": "66", "issue": null, "pages": "103291", "issn-l": null}, "abstract": "Many milestones in medical history rest on animal modeling of human diseases. The SARS-CoV-2 pandemic has evoked a tremendous investigative effort primarily centered on clinical studies. However, several animal SARS-CoV-2/COVID-19 models have been developed and pre-clinical findings aimed at supporting clinical evidence rapidly emerge. In this review, we characterize the existing animal models exposing their relevance and limitations as well as outline their utility in COVID-19 drug and vaccine development. Concurrently, we summarize the status of clinical trial research and discuss the novel tactics utilized in the largest multi-center trials aiming to accelerate generation of reliable results that may subsequently shape COVID-19 clinical treatment practices. We also highlight areas of improvement for animal studies in order to elevate their translational utility. In pandemics, to optimize the use of strained resources in a short time-frame, optimizing and strengthening the synergy between the preclinical and clinical domains is pivotal.", "doi": "10.1016/j.ebiom.2021.103291", "pmid": "33813139", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2352-3964(21)00084-0"}], "notes": [], "created": "2021-04-06T10:06:30.011Z", "modified": "2021-04-06T10:06:30.022Z"}, {"entity": "publication", "iuid": "8ed7dd2bcc9d426189a98e28e0f3d1f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ed7dd2bcc9d426189a98e28e0f3d1f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ed7dd2bcc9d426189a98e28e0f3d1f2"}}, "title": "Using the COVID-19 pandemic to reimagine global health teaching in high-income countries.", "authors": [{"family": "Atkins", "given": "Salla", "initials": "S"}, {"family": "Banerjee", "given": "Ananya Tina", "initials": "AT"}, {"family": "Bachynski", "given": "Kathleen", "initials": "K"}, {"family": "Daftary", "given": "Amrita", "initials": "A"}, {"family": "Desai", "given": "Gauri", "initials": "G"}, {"family": "Gross", "given": "Aeyal", "initials": "A"}, {"family": "Hedt-Gauthier", "given": "Bethany", "initials": "B"}, {"family": "Mendenhall", "given": "Emily", "initials": "E"}, {"family": "Meier", "given": "Benjamin Mason", "initials": "BM"}, {"family": "Nixon", "given": "Stephanie A", "initials": "SA"}, {"family": "Nolan", "given": "Ann", "initials": "A"}, {"family": "Palermo", "given": "Tia M", "initials": "TM"}, {"family": "Phelan", "given": "Alexandra", "initials": "A"}, {"family": "Pyzik", "given": "Oksana", "initials": "O"}, {"family": "Roach", "given": "Pamela", "initials": "P"}, {"family": "Sangaramoorthy", "given": "Thurka", "initials": "T"}, {"family": "Standley", "given": "Claire J", "initials": "CJ"}, {"family": "Yamey", "given": "Gavin", "initials": "G"}, {"family": "Abimbola", "given": "Seye", "initials": "S"}, {"family": "Pai", "given": "Madhukar", "initials": "M"}], "type": "editorial", "published": "2021-04-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "4", "issn-l": "2059-7908"}, "abstract": null, "doi": "10.1136/bmjgh-2021-005649", "pmid": "33811100", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-005649"}], "notes": [], "created": "2021-04-06T10:22:25.858Z", "modified": "2021-04-06T10:22:25.868Z"}, {"entity": "publication", "iuid": "95af88ba4a9a4369936c0f0d5dcea2d8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95af88ba4a9a4369936c0f0d5dcea2d8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95af88ba4a9a4369936c0f0d5dcea2d8"}}, "title": "Undiagnosed SARS-CoV-2 infection and outcome in patients with acute MI and no COVID-19 symptoms.", "authors": [{"family": "Akhtar", "given": "Zubair", "initials": "Z"}, {"family": "Chowdhury", "given": "Fahmida", "initials": "F"}, {"family": "Aleem", "given": "Mohammad Abdul", "initials": "MA"}, {"family": "Ghosh", "given": "Probir Kumar", "initials": "PK"}, {"family": "Rahman", "given": "Mahmudur", "initials": "M"}, {"family": "Rahman", "given": "Mustafizur", "initials": "M"}, {"family": "Hossain", "given": "Mohammad Enayet", "initials": "ME"}, {"family": "Sumiya", "given": "Mariya Kibtiya", "initials": "MK"}, {"family": "Islam", "given": "A K M Monwarul", "initials": "AKMM"}, {"family": "Uddin", "given": "Mir Jamal", "initials": "MJ"}, {"family": "MacIntyre", "given": "C Raina", "initials": "CR"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "Frobert", "given": "Ole", "initials": "O"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Open Heart", "issn": "2053-3624", "volume": "8", "issue": "1", "issn-l": null}, "abstract": "We aimed to determine the prevalence and outcome of occult infection with SARS-CoV-2 and influenza in patients presenting with myocardial infarction (MI) without COVID-19 symptoms.\n\nWe conducted an observational study from 28 June to 11 August 2020, enrolling patients admitted to the National Institute of Cardiovascular Disease Hospital, Dhaka, Bangladesh, with ST-segment elevation MI (STEMI) or non-ST-segment elevation MI who did not meet WHO criteria for suspected COVID-19. Samples were collected by nasopharyngeal swab to test for SARS-CoV-2 and influenza virus by real-time reverse transcriptase PCR. We followed up patients at 3 months (13 weeks) postadmission to record adverse cardiovascular outcomes: all-cause death, new MI, heart failure and new percutaneous coronary intervention or stent thrombosis. Survival analysis was performed using the Kaplan-Meier method.\n\nWe enrolled 280 patients with MI, 79% male, mean age 54.5\u00b111.8 years, 140 of whom were diagnosed with STEMI. We found 36 (13%) to be infected with SARS-CoV-2 and 1 with influenza. There was no significant difference between mortality rate observed among SARS-CoV-2 infected patients compared with non-infected (5 (14%) vs 26 (11%); p=0.564). A numerically shorter median time to a recurrent cardiovascular event was recorded among SARS-CoV-2 infected compared with non-infected patients (21 days, IQR: 8-46 vs 27 days, IQR: 7-44; p=0.378).\n\nWe found a substantial rate of occult SARS-CoV-2 infection in the studied cohort, suggesting SARS-CoV-2 may precipitate MI. Asymptomatic patients with COVID-19 admitted with MI may contribute to disease transmission and warrants widespread testing of hospital admissions.", "doi": "10.1136/openhrt-2021-001617", "pmid": "33811137", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "openhrt-2021-001617"}], "notes": [], "created": "2021-04-06T10:19:09.211Z", "modified": "2021-04-06T10:21:37.251Z"}, {"entity": "publication", "iuid": "274bda03653b48a7b4e0a8099fda6a9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/274bda03653b48a7b4e0a8099fda6a9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/274bda03653b48a7b4e0a8099fda6a9c"}}, "title": "Second versus first wave of COVID-19 deaths: Shifts in age distribution and in nursing home fatalities.", "authors": [{"family": "Ioannidis", "given": "John P A", "initials": "JPA"}, {"family": "Axfors", "given": "Cathrine", "initials": "C"}, {"family": "Contopoulos-Ioannidis", "given": "Despina G", "initials": "DG"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Environ Res", "issn": "1096-0953", "volume": "195", "issue": null, "pages": "110856", "issn-l": "0013-9351"}, "abstract": "To examine whether the age distribution of COVID-19 deaths and the share of deaths in nursing homes changed in the second versus the first pandemic wave.\n\nWe considered all countries that had at least 4000 COVID-19 deaths occurring as of January 14, 2021, at least 200 COVID-19 deaths occurring in each of the two epidemic wave periods; and which had sufficiently detailed information available on the age distribution of these deaths. We also considered countries with data available on COVID-19 deaths of nursing home residents for the two waves.\n\nChange in the second wave versus the first wave in the proportion of COVID-19 deaths occurring in people <50 years (\"young deaths\") among all COVID-19 deaths and among COVID-19 deaths in people <70 years old; and change in the proportion of COVID-19 deaths in nursing home residents among all COVID-19 deaths.\n\nData on age distribution were available for 14 eligible countries. Individuals <50 years old had small absolute difference in their share of the total COVID-19 deaths in the two waves across 13 high-income countries (absolute differences 0.0-0.4%). Their proportion was higher in Ukraine, but it decreased markedly in the second wave. The proportion of young deaths was lower in the second versus the first wave (summary prevalence ratio 0.81, 95% CI 0.71-0.92) with large between-country heterogeneity. The proportion of young deaths among deaths <70 years did not differ significantly across the two waves (summary prevalence ratio 0.96, 95% CI 0.86-1.06). Eligible data on nursing home COVID-19 deaths were available for 11 countries. The share of COVID-19 deaths that were accounted by nursing home residents decreased in the second wave significantly and substantially in 8 countries (prevalence ratio estimates: 0.36 to 0.78), remained the same in Denmark and Norway and markedly increased in Australia.\n\nIn the examined countries, age distribution of COVID-19 deaths has been fairly similar in the second versus the first wave, but the contribution of COVID-19 deaths in nursing home residents to total fatalities has decreased in most countries in the second wave.", "doi": "10.1016/j.envres.2021.110856", "pmid": "33581086", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0013-9351(21)00150-X"}, {"db": "pmc", "key": "PMC7875012"}], "notes": [], "created": "2021-02-15T07:51:34.990Z", "modified": "2021-07-14T07:56:41.505Z"}, {"entity": "publication", "iuid": "d302fafc56674dd383657bc91dd6780e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d302fafc56674dd383657bc91dd6780e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d302fafc56674dd383657bc91dd6780e"}}, "title": "Reporting suspicions of long COVID in children is justified during this global emergency.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF", "orcid": "0000-0003-1024-5602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1d5e45881a7469ca20a0eb360d891cc.json"}}], "type": "letter", "published": "2021-04-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": "110", "issue": "4", "pages": "1373"}, "abstract": "I would like to thank Peny and Valind (1) for raising a number of issues with regard to my recent paper in Acta Paediatrica, which was based on parental reports of what appeared to be long COVID in Sweden (2). The parents approached a number of medical professionals, including me, following discussions on social media about how their children were experiencing worrying ongoing symptoms during the current COVID-19 pandemic.", "doi": "10.1111/apa.15762", "pmid": "33459404", "labels": {"Type: Other": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pmc", "key": "PMC8013867"}], "notes": [], "created": "2021-01-22T09:17:52.957Z", "modified": "2021-07-09T12:50:41.953Z"}, {"entity": "publication", "iuid": "85e87380177046388d486d1e87652a60", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/85e87380177046388d486d1e87652a60.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/85e87380177046388d486d1e87652a60"}}, "title": "OncoAlert Round Table Discussions: The Global COVID-19 Experience.", "authors": [{"family": "Morgan", "given": "Gilberto", "initials": "G"}, {"family": "de Azambuja", "given": "Evandro", "initials": "E"}, {"family": "Punie", "given": "Kevin", "initials": "K"}, {"family": "Ades", "given": "Felipe", "initials": "F"}, {"family": "Heinrich", "given": "Kathrin", "initials": "K"}, {"family": "Personeni", "given": "Nicola", "initials": "N"}, {"family": "Rahme", "given": "Ramy", "initials": "R"}, {"family": "Ferrara", "given": "Roberto", "initials": "R"}, {"family": "Pels", "given": "Kevin", "initials": "K"}, {"family": "Garassino", "given": "Marina", "initials": "M"}, {"family": "von Bergwelt-Baildon", "given": "Michael", "initials": "M"}, {"family": "Lopes", "given": "Gilberto", "initials": "G"}, {"family": "Barlesi", "given": "Fabrice", "initials": "F"}, {"family": "Choueiri", "given": "Toni K", "initials": "TK"}, {"family": "Burris", "given": "Howard", "initials": "H"}, {"family": "Peters", "given": "Solange", "initials": "S"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "JCO Glob Oncol", "issn": "2687-8941", "volume": "7", "issue": null, "pages": "455-463", "issn-l": null}, "abstract": "The speed and spread of the COVID-19 pandemic has been affecting the entire world for the past several months. OncoAlert is a social media network made up of more than 140 oncology stakeholders: oncologists (medical, radiation, and surgical), oncology nurses, and patient advocates who share the mission of fighting cancer by means of education and dissemination of information. As a response to the COVID-19 pandemic, OncoAlert hosted The Round Table Discussions. We have documented this effort along with further discussion about the COVID-19 pandemic and the consequences on patients living with cancer to disseminate this information to our colleagues worldwide.", "doi": "10.1200/GO.20.00603", "pmid": "33822643", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-04-07T10:07:54.625Z", "modified": "2021-04-07T10:07:54.648Z"}, {"entity": "publication", "iuid": "ee6c4a2899d04e1682c03838cdd1d575", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee6c4a2899d04e1682c03838cdd1d575.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee6c4a2899d04e1682c03838cdd1d575"}}, "title": "No country or continent is on its own in the ongoing COVID-19 pandemic.", "authors": [{"family": "Johansen", "given": "Kari", "initials": "K"}, {"family": "Nohynek", "given": "Hanna", "initials": "H"}], "type": "editorial", "published": "2021-04-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "17", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2021.26.17.2100430", "pmid": "33928901", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-05-04T16:03:43.303Z", "modified": "2021-05-04T16:03:43.313Z"}, {"entity": "publication", "iuid": "68d673b1ce8746409bf731b7cf161c36", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68d673b1ce8746409bf731b7cf161c36.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68d673b1ce8746409bf731b7cf161c36"}}, "title": "Next-generation field courses: Integrating Open Science and online learning.", "authors": [{"family": "Geange", "given": "Sonya R", "initials": "SR"}, {"family": "von Oppen", "given": "Jonathan", "initials": "J"}, {"family": "Strydom", "given": "Tanya", "initials": "T"}, {"family": "Boakye", "given": "Mickey", "initials": "M"}, {"family": "Gauthier", "given": "Tasha-Leigh J", "initials": "TJ"}, {"family": "Gya", "given": "Ragnhild", "initials": "R"}, {"family": "Halbritter", "given": "Aud H", "initials": "AH"}, {"family": "Jessup", "given": "Laura H", "initials": "LH"}, {"family": "Middleton", "given": "Sara L", "initials": "SL"}, {"family": "Navarro", "given": "Jocelyn", "initials": "J"}, {"family": "Pierfederici", "given": "Maria Elisa", "initials": "ME"}, {"family": "Chac\u00f3n-Labella", "given": "Julia", "initials": "J"}, {"family": "Cotner", "given": "Sehoya", "initials": "S"}, {"family": "Farfan-Rios", "given": "William", "initials": "W"}, {"family": "Maitner", "given": "Brian S", "initials": "BS"}, {"family": "Michaletz", "given": "Sean T", "initials": "ST"}, {"family": "Telford", "given": "Richard J", "initials": "RJ"}, {"family": "Enquist", "given": "Brian J", "initials": "BJ"}, {"family": "Vandvik", "given": "Vigdis", "initials": "V"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Ecol Evol", "issn": "2045-7758", "volume": "11", "issue": "8", "pages": "3577-3587", "issn-l": null}, "abstract": "As Open Science practices become more commonplace, there is a need for the next generation of scientists to be well versed in these aspects of scientific research. Yet, many training opportunities for early career researchers (ECRs) could better emphasize or integrate Open Science elements. Field courses provide opportunities for ECRs to apply theoretical knowledge, practice new methodological approaches, and gain an appreciation for the challenges of real-life research, and could provide an excellent platform for integrating training in Open Science practices. Our recent experience, as primarily ECRs engaged in a field course interrupted by COVID-19, led us to reflect on the potential to enhance learning outcomes in field courses by integrating Open Science practices and online learning components. Specifically, we highlight the opportunity for field courses to align teaching activities with the recent developments and trends in how we conduct research, including training in: publishing registered reports, collecting data using standardized methods, adopting high-quality data documentation, managing data through reproducible workflows, and sharing and publishing data through appropriate channels. We also discuss how field courses can use online tools to optimize time in the field, develop open access resources, and cultivate collaborations. By integrating these elements, we suggest that the next generation of field courses will offer excellent arenas for participants to adopt Open Science practices.", "doi": "10.1002/ece3.7009", "pmid": "33898010", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "ECE37009"}, {"db": "pmc", "key": "PMC8057340"}], "notes": [], "created": "2021-04-29T15:27:05.229Z", "modified": "2021-04-29T15:27:05.232Z"}, {"entity": "publication", "iuid": "0d45ddfcbc5047b09fbf45d48525b320", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d45ddfcbc5047b09fbf45d48525b320.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d45ddfcbc5047b09fbf45d48525b320"}}, "title": "National outcomes and characteristics of patients admitted to Swedish intensive care units for COVID-19", "authors": [{"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Blixt", "given": "Patrik Johansson", "initials": "PJ"}, {"family": "\u00c5hman", "given": "Rasmus", "initials": "R"}, {"family": "Engerstr\u00f6m", "given": "Lars", "initials": "L"}, {"family": "Andersson", "given": "Henrik", "initials": "H"}, {"family": "Berggren", "given": "Ritva Kiiski", "initials": "RK"}, {"family": "Tegnell", "given": "Anders", "initials": "A"}, {"family": "McIntyre", "given": "Sarah", "initials": "S"}], "type": "journal-article", "published": "2021-04-00", "journal": {"title": "Eur J Anaesthesiol", "issn": "1365-2346", "volume": "38", "issue": "4", "pages": "335-343", "issn-l": null}, "abstract": "Mortality among patients admitted to intensive care units (ICUs) with COVID-19 is unclear due to variable follow-up periods. Few nationwide data are available to compare risk factors, treatment and outcomes of COVID-19 patients after ICU admission.\n\nTo evaluate baseline characteristics, treatments and 30-day outcomes of patients admitted to Swedish ICUs with COVID-19.\n\nRegistry-based cohort study with prospective data collection.\n\nAdmissions to Swedish ICUs from 6 March to 6 May 2020 with laboratory confirmed COVID-19 disease.\n\nAdult patients admitted to Swedish ICUs.\n\nBaseline characteristics, intensive care treatments and organ failures.\n\nThe primary outcome was 30-day all-cause mortality. A multivariable model was used to determine the independent association between potential predictor variables and death.\n\nWe identified 1563 patients with complete 30-day follow-up. The 30-day all-cause mortality was 26.7%. Median age was 61 [52 to 69], Simplified Acute Physiology Score III (SAPS III) was 53 [46 to 59] and 62.5% had at least one comorbidity. Median PaO2/FiO2 on admission was 97.5 [75.0 to 140.6] mmHg, 74.7% suffered from moderate-to-severe acute respiratory failure. Age, male sex [adjusted odds ratio (aOR) 1.5 (1.1 to 2.2)], SAPS III score [aOR 1.3 (1.2 to 1.4)], severe respiratory failure [aOR 3.0 (2.0 to 4.7)], specific COVID-19 pharmacotherapy [aOR 1.4 (1.0 to 1.9)] and continuous renal replacement therapy [aOR 2.1 (1.5 to 3.0)] were associated with increased mortality. Except for chronic lung disease, the presence of comorbidities was not independently associated with mortality.\n\nThirty-day mortality rate in COVID-19 patients admitted to Swedish ICUs is generally lower than previously reported despite a severe degree of hypoxaemia on admission. Mortality was driven by age, baseline disease severity, the presence and degree of organ failure, rather than pre-existing comorbidities.\n\nNCT04462393.", "doi": "10.1097/eja.0000000000001459", "pmid": "33534266", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00003643-900000000-98244"}, {"db": "ClinicalTrials.gov", "key": "NCT04462393"}], "notes": [], "created": "2021-02-04T18:11:08.535Z", "modified": "2021-06-18T11:08:26.474Z"}, {"entity": "publication", "iuid": "980eb41a0b4c42ee9233958785cdf896", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/980eb41a0b4c42ee9233958785cdf896.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/980eb41a0b4c42ee9233958785cdf896"}}, "title": "Meteorological conditions are heterogeneous factors for COVID-19 risk in China", "authors": [{"family": "Xiao", "given": "Shuang", "initials": "S"}, {"family": "Qi", "given": "Hongchao", "initials": "H"}, {"family": "Ward", "given": "Michael P", "initials": "MP"}, {"family": "Wang", "given": "Wenge", "initials": "W"}, {"family": "Zhang", "given": "Jun", "initials": "J"}, {"family": "Chen", "given": "Yue", "initials": "Y"}, {"family": "Bergquist", "given": "Robert", "initials": "R"}, {"family": "Tu", "given": "Wei", "initials": "W"}, {"family": "Shi", "given": "Runye", "initials": "R"}, {"family": "Hong", "given": "Jie", "initials": "J"}, {"family": "Su", "given": "Qing", "initials": "Q"}, {"family": "Zhao", "given": "Zheng", "initials": "Z"}, {"family": "Ba", "given": "Jianbo", "initials": "J"}, {"family": "Zhang", "given": "Zhijie", "initials": "Z"}], "type": "journal-article", "published": "2021-04-00", "journal": {"title": "Environ Res", "issn": "0013-9351", "volume": null, "issue": null, "pages": "111182", "issn-l": null}, "abstract": null, "doi": "10.1016/j.envres.2021.111182", "pmid": null, "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-04-20T17:52:22.865Z", "modified": "2021-04-23T16:06:36.046Z"}, {"entity": "publication", "iuid": "15dfd044b9124bebb7e41ae9a130eb62", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15dfd044b9124bebb7e41ae9a130eb62.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15dfd044b9124bebb7e41ae9a130eb62"}}, "title": "Long-Haul Post-COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrome: The Swedish Experience.", "authors": [{"family": "Johansson", "given": "Madeleine", "initials": "M"}, {"family": "St\u00e5hlberg", "given": "Marcus", "initials": "M"}, {"family": "Runold", "given": "Michael", "initials": "M"}, {"family": "Nygren-Bonnier", "given": "Malin", "initials": "M"}, {"family": "Nilsson", "given": "Jan", "initials": "J"}, {"family": "Olshansky", "given": "Brian", "initials": "B"}, {"family": "Bruchfeld", "given": "Judith", "initials": "J"}, {"family": "Fedorowski", "given": "Artur", "initials": "A"}], "type": "case reports", "published": "2021-04-00", "journal": {"title": "JACC Case Rep", "issn": "2666-0849", "issn-l": null, "volume": "3", "issue": "4", "pages": "573-580"}, "abstract": "Major clinical centers in Sweden have witnessed an inflow of patients with chronic symptoms following initial outpatient care for coronavirus disease-2019 (COVID-19) infection, suggestive of postural orthostatic tachycardia syndrome. This report presents the first case series of 3 Swedish patients diagnosed with postural orthostatic tachycardia syndrome more than 3 months after the primary COVID-2019 infections. (Level of Difficulty: Intermediate.).", "doi": "10.1016/j.jaccas.2021.01.009", "pmid": "33723532", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Rehabilitation": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "S2666-0849(21)00100-5"}, {"db": "pmc", "key": "PMC7946344"}], "notes": [], "created": "2021-03-17T07:42:54.636Z", "modified": "2021-11-18T12:53:34.532Z"}, {"entity": "publication", "iuid": "7aea0412da344b4f9e2e8ac34ab5196d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7aea0412da344b4f9e2e8ac34ab5196d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7aea0412da344b4f9e2e8ac34ab5196d"}}, "title": "Long COVID-19\u2014it's not over until?", "authors": [{"family": "Yelin", "given": "Dana", "initials": "D"}, {"family": "Margalit", "given": "Ili", "initials": "I"}, {"family": "Yahav", "given": "Dafna", "initials": "D"}, {"family": "Runold", "given": "Michael", "initials": "M"}, {"family": "Bruchfeld", "given": "Judith", "initials": "J"}], "type": "journal-article", "published": "2021-04-00", "journal": {"title": "Clinical Microbiology and Infection", "issn": "1198-743X", "issn-l": null, "volume": "27", "issue": "4", "pages": "506-508"}, "abstract": null, "doi": "10.1016/j.cmi.2020.12.001", "pmid": "33316400", "labels": {"Type: Other": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "S1198-743X(20)30750-3"}], "notes": [], "created": "2020-12-21T10:16:50.007Z", "modified": "2021-07-09T12:52:27.295Z"}, {"entity": "publication", "iuid": "1abc7e14a86640049e495cf1c27e887e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1abc7e14a86640049e495cf1c27e887e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1abc7e14a86640049e495cf1c27e887e"}}, "title": "Incidence of SARS-CoV-2 in people with cystic fibrosis in Europe between February and June 2020", "authors": [{"family": "Naehrlich", "given": "Lutz", "initials": "L"}, {"family": "Orenti", "given": "Annalisa", "initials": "A"}, {"family": "Dunlevy", "given": "Fiona", "initials": "F"}, {"family": "Kasmi", "given": "Irena", "initials": "I"}, {"family": "Harutyunyan", "given": "Satenik", "initials": "S"}, {"family": "Pfleger", "given": "Andreas", "initials": "A"}, {"family": "Keegan", "given": "Svetlana", "initials": "S"}, {"family": "Daneau", "given": "G\u00e9raldine", "initials": "G"}, {"family": "Petrova", "given": "Guergana", "initials": "G"}, {"family": "Tje\u0161i\u0107-Drinkovi\u0107", "given": "Du\u0161ka", "initials": "D"}, {"family": "Yiallouros", "given": "Panayiotis", "initials": "P"}, {"family": "Bilkova", "given": "Alena", "initials": "A"}, {"family": "Olesen", "given": "Hanne Vebert", "initials": "HV"}, {"family": "Burgel", "given": "Pierre R\u00e9gis", "initials": "PR"}, {"family": "Parulava", "given": "Tsitsino", "initials": "T"}, {"family": "Diamantea", "given": "Filia", "initials": "F"}, {"family": "P\u00e1rniczky", "given": "Andrea", "initials": "A"}, {"family": "McKone", "given": "Edward F", "initials": "EF"}, {"family": "Mei-Zahav", "given": "Meir", "initials": "M"}, {"family": "Salvatore", "given": "Marco", "initials": "M"}, {"family": "Colombo", "given": "Carla", "initials": "C"}, {"family": "Aleksejeva", "given": "Elina", "initials": "E"}, {"family": "Malakauskas", "given": "Kestutis", "initials": "K"}, {"family": "Schlesser", "given": "Marc", "initials": "M"}, {"family": "Fustik", "given": "Stojka", "initials": "S"}, {"family": "Turcu", "given": "Oxana", "initials": "O"}, {"family": "Zomer-van Ommen", "given": "Domenique", "initials": "D"}, {"family": "Wathne", "given": "Anita Senstad", "initials": "AS"}, {"family": "Wo\u017aniacki", "given": "\u0141ukasz", "initials": "\u0141"}, {"family": "Pereira", "given": "Lu\u00edsa", "initials": "L"}, {"family": "Pop", "given": "Liviu", "initials": "L"}, {"family": "Kashirskaya", "given": "Nataliya", "initials": "N"}, {"family": "Rodi\u0107", "given": "Milan", "initials": "M"}, {"family": "Kayserova", "given": "Hana", "initials": "H"}, {"family": "Krivecs", "given": "Uro", "initials": "U"}, {"family": "Mondejar-Lopez", "given": "Pedro", "initials": "P"}, {"family": "de Monestrol", "given": "Isabelle", "initials": "I"}, {"family": "Dogru", "given": "Deniz", "initials": "D"}, {"family": "Makukh", "given": "Halyna", "initials": "H"}, {"family": "Cosgriff", "given": "Rebecca", "initials": "R"}, {"family": "van Koningsbruggen-Rietschel", "given": "Silke", "initials": "S"}, {"family": "Jung", "given": "Andreas", "initials": "A"}, {"family": "Bobrovnichy", "given": "Vladimir", "initials": "V"}, {"family": "Bambir", "given": "Ivan", "initials": "I"}, {"family": "Vukic", "given": "Andrea Dugac", "initials": "AD"}, {"family": "Drevinek", "given": "Pavel", "initials": "P"}, {"family": "Jr", "given": "Milan Macek", "initials": "MM"}, {"family": "Corvol", "given": "Harriet", "initials": "H"}, {"family": "Lemonnier-Videau", "given": "Lydie", "initials": "L"}, {"family": "Hatziagorou", "given": "Elpis", "initials": "E"}, {"family": "Fletcher", "given": "Godfrey", "initials": "G"}, {"family": "Padoan", "given": "Rita", "initials": "R"}, {"family": "Gulmans", "given": "Vincent", "initials": "V"}, {"family": "Bakkeheim", "given": "Egil", "initials": "E"}, {"family": "Kondratyeva", "given": "Elena", "initials": "E"}, {"family": "Amelina", "given": "Elena", "initials": "E"}, {"family": "Zhekaite", "given": "Elena", "initials": "E"}, {"family": "Simonova", "given": "Olga", "initials": "O"}, {"family": "Pastor-Vivero", "given": "Maria Dolores", "initials": "MD"}, {"family": "Lindblad", "given": "Anders", "initials": "A"}, {"family": "G\u00f6kdemir", "given": "Yasemin", "initials": "Y"}, {"family": "Pekcan", "given": "Sevgi", "initials": "S"}, {"family": "Brownlee", "given": "Keith", "initials": "K"}, {"family": "McClenaghan", "given": "Elliott", "initials": "E"}, {"family": "Carr", "given": "Siobh\u00e1n", "initials": "S"}, {"family": "Lammertyn", "given": "Elise", "initials": "E"}, {"family": "Zolin", "given": "Anna", "initials": "A"}, {"family": "Fox", "given": "Alice", "initials": "A"}, {"family": "Krasnyk", "given": "Marko", "initials": "M"}, {"family": "Van Rens", "given": "Jacqui", "initials": "J"}], "type": "journal-article", "published": "2021-04-00", "journal": {"title": "Journal of Cystic Fibrosis", "issn": "1569-1993", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.jcf.2021.03.017", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-21T17:25:33.722Z", "modified": "2021-05-21T17:25:55.844Z"}, {"entity": "publication", "iuid": "1782e69f4e5249c29b177151ee5e172b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1782e69f4e5249c29b177151ee5e172b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1782e69f4e5249c29b177151ee5e172b"}}, "title": "From a crisis to an opportunity: Eight insights for doing science in the COVID-19 era and beyond.", "authors": [{"family": "Chac\u00f3n-Labella", "given": "Julia", "initials": "J"}, {"family": "Boakye", "given": "Mickey", "initials": "M"}, {"family": "Enquist", "given": "Brian J", "initials": "BJ"}, {"family": "Farfan-Rios", "given": "William", "initials": "W"}, {"family": "Gya", "given": "Ragnhild", "initials": "R"}, {"family": "Halbritter", "given": "Aud H", "initials": "AH"}, {"family": "Middleton", "given": "Sara L", "initials": "SL"}, {"family": "von Oppen", "given": "Jonathan", "initials": "J"}, {"family": "Pastor-Ploskonka", "given": "Samuel", "initials": "S"}, {"family": "Strydom", "given": "Tanya", "initials": "T"}, {"family": "Vandvik", "given": "Vigdis", "initials": "V"}, {"family": "Geange", "given": "Sonya R", "initials": "SR"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Ecol Evol", "issn": "2045-7758", "volume": "11", "issue": "8", "pages": "3588-3596", "issn-l": null}, "abstract": "The COVID-19 crisis has forced researchers in Ecology to change the way we work almost overnight. Nonetheless, the pandemic has provided us with several novel components for a new way of conducting science. In this perspective piece, we summarize eight central insights that are helping us, as early career researchers, navigate the uncertainties, fears, and challenges of advancing science during the COVID-19 pandemic. We highlight how innovative, collaborative, and often Open Science-driven developments that have arisen from this crisis can form a blueprint for a community reinvention in academia. Our insights include personal approaches to managing our new reality, maintaining capacity to focus and resilience in our projects, and a variety of tools that facilitate remote collaboration. We also highlight how, at a community level, we can take advantage of online communication platforms for gaining accessibility to conferences and meetings, and for maintaining research networks and community engagement while promoting a more diverse and inclusive community. Overall, we are confident that these practices can support a more inclusive and kinder scientific culture for the longer term.", "doi": "10.1002/ece3.7026", "pmid": "33898011", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "ECE37026"}, {"db": "pmc", "key": "PMC8057324"}], "notes": [], "created": "2021-04-29T10:30:06.622Z", "modified": "2021-04-29T10:31:02.408Z"}, {"entity": "publication", "iuid": "bd9a35673402475f8d9617e727313371", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bd9a35673402475f8d9617e727313371.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bd9a35673402475f8d9617e727313371"}}, "title": "Error rates in SARS-CoV-2 testing examined with Bayes' theorem.", "authors": [{"family": "Bentley", "given": "P M", "initials": "PM"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": "7", "issue": "4", "pages": "e06905", "issn-l": null}, "abstract": "The SARS-CoV-2 pandemic has created a demand for large scale testing, as part of the effort to understand and control transmission. It is important to quantify the error rates of test equipment under field conditions, which might differ significantly from those obtained in the laboratory. A literature review on SARS-CoV-2 reverse-transcription polymerase chain reaction (RT-PCR) is used to construct a clinical test confusion matrix. A simple correction method for bulk test results is then demonstrated with examples. The required sensitivity and specificity of a test are explored for societal needs and use cases, before a sequential analysis of common example scenarios is explored. The analysis suggests that many of the people with mild symptoms and positive test results are unlikely to be infected with SARS-CoV-2 in some regions. It is concluded that current and foreseen alternative tests can not be used to \"clear\" people as being non-infected. Recommendations are given that regional authorities must establish a programme to monitor operational test characteristics before launching large scale testing; and that large scale testing for tracing infection networks in some regions is not viable, but may be possible in a focused way that does not exceed the working capacity of the laboratories staffed by competent experts. RT-PCR tests can not be solely relied upon as the gold standard for SARS-CoV-2 diagnosis at scale, instead clinical assessment supported by a range of expert diagnostic tests should be used.", "doi": "10.1016/j.heliyon.2021.e06905", "pmid": "33937546", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)01008-2"}, {"db": "pmc", "key": "PMC8080131"}], "notes": [], "created": "2021-05-04T15:58:32.202Z", "modified": "2021-05-04T15:58:32.212Z"}, {"entity": "publication", "iuid": "54926588f7d343be90f590e89292ffa1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54926588f7d343be90f590e89292ffa1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54926588f7d343be90f590e89292ffa1"}}, "title": "Elevated factor V activity and antigen levels in patients with Covid\u201019 are related to disease severity and 30\u2010day mortality", "authors": [{"family": "Meijenfeldt", "given": "Fien A", "initials": "FA", "orcid": "0000-0003-0274-2414", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76b5cb67f6e243459441f06d41f0816c.json"}}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Adelmeijer", "given": "Jelle", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Thalin", "given": "Charlotte", "initials": "C"}, {"family": "Lisman", "given": "Ton", "initials": "T", "orcid": "0000-0002-3503-7140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7431e810d13c443ca5dacbf5d368e60b.json"}}], "type": "journal-article", "published": "2021-04-00", "journal": {"title": "Am J Hematol", "issn": "0361-8609", "issn-l": null, "volume": "96", "issue": "4", "pages": null}, "abstract": null, "doi": "10.1002/ajh.26085", "pmid": "33393103", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-04T16:18:01.104Z", "modified": "2021-12-12T18:06:38.589Z"}, {"entity": "publication", "iuid": "6263eec832f54ef69a97f6d3d0c37763", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6263eec832f54ef69a97f6d3d0c37763.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6263eec832f54ef69a97f6d3d0c37763"}}, "title": "Effectiveness of the Comirnaty (BNT162b2, BioNTech/Pfizer) vaccine in preventing SARS-CoV-2 infection among healthcare workers, Treviso province, Veneto region, Italy, 27 December 2020 to 24 March 2021.", "authors": [{"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Ramigni", "given": "Mauro", "initials": "M"}, {"family": "Gobbetto", "given": "Valentina", "initials": "V"}, {"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Piovesan", "given": "Cinzia", "initials": "C"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "17", "issn-l": null}, "abstract": "Data on effectiveness of the BioNTech-/Pfizer COVID-19 vaccine in real-world settings are limited. In a study of 6,423 healthcare workers in Treviso Province, Italy, we estimated that, within the time intervals of 14-21 days from the first and at least 7 days from the second dose, vaccine effectiveness in preventing SARS-CoV-2 infection was 84% (95% confidence interval (CI): 40-96) and 95% (95% CI: 62-99), respectively. These results could support the ongoing vaccination campaigns by providing evidence for targeted communication.", "doi": "10.2807/1560-7917.ES.2021.26.17.2100420", "pmid": "33928898", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-05-04T16:04:18.214Z", "modified": "2021-05-04T16:04:18.224Z"}, {"entity": "publication", "iuid": "9931c97142514ddaa8f78e17e737d5fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9931c97142514ddaa8f78e17e737d5fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9931c97142514ddaa8f78e17e737d5fd"}}, "title": "Dependence of SARS-CoV-2 infection on cholesterol-rich lipid raft and endosomal acidification", "authors": [{"family": "Li", "given": "Xiaowei", "initials": "X"}, {"family": "Zhu", "given": "Wenhua", "initials": "W"}, {"family": "Fan", "given": "Meiyang", "initials": "M"}, {"family": "Zhang", "given": "Jing", "initials": "J"}, {"family": "Peng", "given": "Yizhao", "initials": "Y"}, {"family": "Huang", "given": "Fumeng", "initials": "F"}, {"family": "Wang", "given": "Nan", "initials": "N"}, {"family": "He", "given": "Langchong", "initials": "L"}, {"family": "Zhang", "given": "Lei", "initials": "L"}, {"family": "Holmdahl", "given": "Rikard", "initials": "R"}, {"family": "Meng", "given": "Liesu", "initials": "L"}, {"family": "Lu", "given": "Shemin", "initials": "S"}], "type": "journal-article", "published": "2021-04-00", "journal": {"title": "Comput Struct Biotechnol J", "issn": "2001-0370", "issn-l": "2001-0370", "volume": null, "issue": null, "pages": null}, "abstract": "Coronavirus disease 2019 is a kind of viral pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the mechanism whereby SARS-CoV-2 invades host cells remains poorly understood. Here we used SARS-CoV-2 pseudoviruses to infect human angiotensin-converting enzyme 2 (ACE2) expressing HEK293T cells and evaluated virus infection. We confirmed that SARS-CoV-2 entry was dependent on ACE2 and sensitive to pH of endosome/lysosome in HEK293T cells. The infection of SARS-CoV-2 pseudoviruses is independent of dynamin, clathrin, caveolin and endophilin A2, as well as macropinocytosis. Instead, we found that the infection of SARS-CoV-2 pseudoviruses was cholesterol-rich lipid raft dependent. Cholesterol depletion of cell membranes with methyl-\u03b2-cyclodextrin resulted in reduction of pseudovirus infection. The infection of SARS-CoV-2 pseudoviruses resumed with cholesterol supplementation. Together, cholesterol-rich lipid rafts, and endosomal acidification, are key steps of SARS-CoV-2 required for infection of host cells. Therefore, our finding expands the understanding of SARS-CoV-2 entry mechanism and provides a new anti-SARS-CoV-2 strategy.", "doi": "10.1016/j.csbj.2021.04.001", "pmid": "33850607", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-04-15T10:33:48.387Z", "modified": "2021-04-21T08:55:37.850Z"}, {"entity": "publication", "iuid": "587fb02cc83e473a8da6f20bc7edafce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/587fb02cc83e473a8da6f20bc7edafce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/587fb02cc83e473a8da6f20bc7edafce"}}, "title": "Cloth Masks May Prevent Transmission of COVID-19", "authors": [{"family": "Clase", "given": "Catherine M", "initials": "CM"}, {"family": "Fu", "given": "Edouard L", "initials": "EL"}, {"family": "Jardine", "given": "Meg", "initials": "M"}, {"family": "Mann", "given": "Johannes F E", "initials": "JFE"}, {"family": "Carrero", "given": "Juan J", "initials": "JJ"}], "type": "journal-article", "published": "2021-04-00", "journal": {"title": "Ann Intern Med", "issn": "0003-4819", "volume": "174", "issue": "4", "pages": "580", "issn-l": null}, "abstract": null, "doi": "10.7326/l21-0091", "pmid": null, "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-04-20T17:52:54.999Z", "modified": "2021-04-20T17:52:55.012Z"}, {"entity": "publication", "iuid": "d5a7eec396b04e21a41f59382f5a79ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5a7eec396b04e21a41f59382f5a79ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5a7eec396b04e21a41f59382f5a79ee"}}, "title": "Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021.", "authors": [{"family": "Funk", "given": "Tjede", "initials": "T"}, {"family": "Pharris", "given": "Anastasia", "initials": "A"}, {"family": "Spiteri", "given": "Gianfranco", "initials": "G"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "Carr", "given": "Michael", "initials": "M"}, {"family": "Gonzalez", "given": "Gabriel", "initials": "G"}, {"family": "Garcia-Leon", "given": "Alejandro", "initials": "A"}, {"family": "Crispie", "given": "Fiona", "initials": "F"}, {"family": "O'Connor", "given": "Lois", "initials": "L"}, {"family": "Murphy", "given": "Niamh", "initials": "N"}, {"family": "Mossong", "given": "Jo\u00ebl", "initials": "J"}, {"family": "Vergison", "given": "Anne", "initials": "A"}, {"family": "Wienecke-Baldacchino", "given": "Anke K", "initials": "AK"}, {"family": "Abdelrahman", "given": "Tamir", "initials": "T"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Di Martino", "given": "Angela", "initials": "A"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Lo Presti", "given": "Alessandra", "initials": "A"}, {"family": "Casaca", "given": "Pedro", "initials": "P"}, {"family": "Moreno", "given": "Joana", "initials": "J"}, {"family": "Borges", "given": "V\u00edtor", "initials": "V"}, {"family": "Isidro", "given": "Joana", "initials": "J"}, {"family": "Ferreira", "given": "Rita", "initials": "R"}, {"family": "Gomes", "given": "Jo\u00e3o Paulo", "initials": "JP"}, {"family": "Dotsenko", "given": "Liidia", "initials": "L"}, {"family": "Suija", "given": "Heleene", "initials": "H"}, {"family": "Epstein", "given": "Jevgenia", "initials": "J"}, {"family": "Sadikova", "given": "Olga", "initials": "O"}, {"family": "Sepp", "given": "Hanna", "initials": "H"}, {"family": "Ikonen", "given": "Niina", "initials": "N"}, {"family": "Savolainen-Kopra", "given": "Carita", "initials": "C"}, {"family": "Blomqvist", "given": "Soile", "initials": "S"}, {"family": "M\u00f6tt\u00f6nen", "given": "Teemu", "initials": "T"}, {"family": "Helve", "given": "Otto", "initials": "O"}, {"family": "Gomes-Dias", "given": "Joana", "initials": "J"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "COVID study groups", "given": "", "initials": ""}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "16", "issn-l": null}, "abstract": "We compared 19,207 cases of SARS-CoV-2 variant B.1.1.7/S gene target failure (SGTF), 436 B.1.351 and 352 P.1 to non-variant cases reported by seven European countries. COVID-19 cases with these variants had significantly higher adjusted odds ratios for hospitalisation (B.1.1.7/SGTF: 1.7, 95% confidence interval (CI): 1.0-2.9; B.1.351: 3.6, 95% CI: 2.1-6.2; P.1: 2.6, 95% CI: 1.4-4.8) and B.1.1.7/SGTF and P.1 cases also for intensive care admission (B.1.1.7/SGTF: 2.3, 95% CI: 1.4-3.5; P.1: 2.2, 95% CI: 1.7-2.8).", "doi": "10.2807/1560-7917.ES.2021.26.16.2100348", "pmid": "33890566", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "URL", "key": "https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2021.26.16.2100348", "description": "All data is included in the supplementary material"}], "notes": [], "created": "2021-04-29T15:38:29.078Z", "modified": "2021-11-18T12:55:13.856Z"}, {"entity": "publication", "iuid": "f80c158699b2466c9ef82f8f15e35e63", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f80c158699b2466c9ef82f8f15e35e63.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f80c158699b2466c9ef82f8f15e35e63"}}, "title": "Attributes and predictors of long COVID.", "authors": [{"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Murray", "given": "Benjamin", "initials": "B", "orcid": "0000-0002-2413-923X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebec738df0224bf4874fd6c08fd23fae.json"}}, {"family": "Varsavsky", "given": "Thomas", "initials": "T"}, {"family": "Graham", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-4170-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f5f4e19812a46ed9e873732ec25e28d.json"}}, {"family": "Penfold", "given": "Rose S", "initials": "RS"}, {"family": "Bowyer", "given": "Ruth C", "initials": "RC", "orcid": "0000-0002-6941-8160", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eebaf361c184499ca6729aa60cc0af3d.json"}}, {"family": "Pujol", "given": "Joan Capdevila", "initials": "JC", "orcid": "0000-0003-1658-1076", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60965a027a4b4d048728748f09c98594.json"}}, {"family": "Klaser", "given": "Kerstin", "initials": "K"}, {"family": "Antonelli", "given": "Michela", "initials": "M"}, {"family": "Canas", "given": "Liane S", "initials": "LS"}, {"family": "Molteni", "given": "Erika", "initials": "E", "orcid": "0000-0001-7773-8140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9aed1fbe444b48d4bfacb12050953c8e.json"}}, {"family": "Modat", "given": "Marc", "initials": "M"}, {"family": "Jorge Cardoso", "given": "M", "initials": "M", "orcid": "0000-0003-1284-2558", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0ed3abec67644e186650e1d1dcbbe0b.json"}}, {"family": "May", "given": "Anna", "initials": "A"}, {"family": "Ganesh", "given": "Sajaysurya", "initials": "S", "orcid": "0000-0002-3720-4176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6dbf91180806442082ce6732c1b75923.json"}}, {"family": "Davies", "given": "Richard", "initials": "R", "orcid": "0000-0003-2050-3994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b82cc92615f462d9af0153a6fb94fde.json"}}, {"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Drew", "given": "David A", "initials": "DA", "orcid": "0000-0002-8813-0816", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd3a2cffdc104f18b8684cf4f27d68b2.json"}}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Merino", "given": "Jordi", "initials": "J", "orcid": "0000-0001-8312-1438", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12ab049914a542b39affcfb4196861d2.json"}}, {"family": "Tsereteli", "given": "Neli", "initials": "N"}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f34c0d3602439abe6096293c7c732d.json"}}, {"family": "Gomez", "given": "Maria F", "initials": "MF", "orcid": "0000-0001-6210-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e09e37219c4f42c8a7b3a982da523859.json"}}, {"family": "Duncan", "given": "Emma L", "initials": "EL"}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874802ae65824a90ba50eabdeabb8356.json"}}, {"family": "Williams", "given": "Frances M K", "initials": "FMK", "orcid": "0000-0002-2998-2744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/87a6db988c2e421f81fce7773436aefa.json"}}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74cf1f7094744ee289fa5df041e7cb5b.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-7284-6767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeefbf47fd384d5390109fe1a903bd18.json"}}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Ourselin", "given": "Sebastien", "initials": "S", "orcid": "0000-0002-5694-5340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74c7b9b1633144879042d198c7205656.json"}}, {"family": "Spector", "given": "Tim", "initials": "T", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956", "volume": "27", "issue": "4", "pages": "626-631"}, "abstract": "Reports of long-lasting coronavirus disease 2019 (COVID-19) symptoms, the so-called 'long COVID', are rising but little is known about prevalence, risk factors or whether it is possible to predict a protracted course early in the disease. We analyzed data from 4,182 incident cases of COVID-19 in which individuals self-reported their symptoms prospectively in the COVID Symptom Study app1. A total of 558 (13.3%) participants reported symptoms lasting \u226528 days, 189 (4.5%) for \u22658 weeks and 95 (2.3%) for \u226512 weeks. Long COVID was characterized by symptoms of fatigue, headache, dyspnea and anosmia and was more likely with increasing age and body mass index and female sex. Experiencing more than five symptoms during the first week of illness was associated with long COVID (odds ratio = 3.53 (2.76-4.50)). A simple model to distinguish between short COVID and long COVID at 7 days (total sample size, n = 2,149) showed an area under the curve of the receiver operating characteristic curve of 76%, with replication in an independent sample of 2,472 individuals who were positive for severe acute respiratory syndrome coronavirus 2. This model could be used to identify individuals at risk of long COVID for trials of prevention or treatment and to plan education and rehabilitation services.", "doi": "10.1038/s41591-021-01292-y", "pmid": "33692530", "labels": {"Category: Health": null, "Category: Public Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "mid", "key": "EMS131037"}, {"db": "pmc", "key": "PMC7611399"}, {"db": "pii", "key": "10.1038/s41591-021-01292-y"}], "notes": [], "created": "2021-01-07T16:47:03.626Z", "modified": "2023-06-19T15:07:13.510Z"}, {"entity": "publication", "iuid": "3a7826632dde417d8a75ee0117438d85", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a7826632dde417d8a75ee0117438d85.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a7826632dde417d8a75ee0117438d85"}}, "title": "Assessing mandatory stay-at-home and business closure effects on the spread of COVID-19.", "authors": [{"family": "Bendavid", "given": "Eran", "initials": "E", "orcid": "0000-0002-8364-4711", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79b88b45b7634279bdcb7b3629caae9f.json"}}, {"family": "Oh", "given": "Christopher", "initials": "C"}, {"family": "Bhattacharya", "given": "Jay", "initials": "J", "orcid": "0000-0003-3867-3174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12aad76bb20d4b29b500b194f3e84d17.json"}}, {"family": "Ioannidis", "given": "John P A", "initials": "JPA", "orcid": "0000-0003-3118-6859", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9844ea41bc554157a721820d7986a442.json"}}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Eur J Clin Invest", "issn": "1365-2362", "volume": "51", "issue": "4", "pages": "e13484", "issn-l": null}, "abstract": "The most restrictive nonpharmaceutical interventions (NPIs) for controlling the spread of COVID-19 are mandatory stay-at-home and business closures. Given the consequences of these policies, it is important to assess their effects. We evaluate the effects on epidemic case growth of more restrictive NPIs (mrNPIs), above and beyond those of less-restrictive NPIs (lrNPIs).\n\nWe first estimate COVID-19 case growth in relation to any NPI implementation in subnational regions of 10 countries: England, France, Germany, Iran, Italy, Netherlands, Spain, South Korea, Sweden and the United States. Using first-difference models with fixed effects, we isolate the effects of mrNPIs by subtracting the combined effects of lrNPIs and epidemic dynamics from all NPIs. We use case growth in Sweden and South Korea, 2 countries that did not implement mandatory stay-at-home and business closures, as comparison countries for the other 8 countries (16 total comparisons).\n\nImplementing any NPIs was associated with significant reductions in case growth in 9 out of 10 study countries, including South Korea and Sweden that implemented only lrNPIs (Spain had a nonsignificant effect). After subtracting the epidemic and lrNPI effects, we find no clear, significant beneficial effect of mrNPIs on case growth in any country. In France, for example, the effect of mrNPIs was +7% (95% CI: -5%-19%) when compared with Sweden and + 13% (-12%-38%) when compared with South Korea (positive means pro-contagion). The 95% confidence intervals excluded 30% declines in all 16 comparisons and 15% declines in 11/16 comparisons.\n\nWhile small benefits cannot be excluded, we do not find significant benefits on case growth of more restrictive NPIs. Similar reductions in case growth may be achievable with less-restrictive interventions.", "doi": "10.1111/eci.13484", "pmid": "33400268", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7883103"}], "notes": [], "created": "2023-01-13T13:30:03.001Z", "modified": "2023-01-13T13:30:03.092Z"}, {"entity": "publication", "iuid": "cbb613cf35da41c8be1815197e30108d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cbb613cf35da41c8be1815197e30108d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cbb613cf35da41c8be1815197e30108d"}}, "title": "SARS-CoV-2 infection incidence during the first and second COVID-19 waves in Italy.", "authors": [{"family": "Vinceti", "given": "Marco", "initials": "M"}, {"family": "Filippini", "given": "Tommaso", "initials": "T"}, {"family": "Rothman", "given": "Kenneth J", "initials": "KJ"}, {"family": "Di Federico", "given": "Silvia", "initials": "S"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}], "type": "journal article", "published": "2021-03-31", "journal": {"title": "Environ Res", "issn": "1096-0953", "volume": null, "issue": null, "pages": "111097", "issn-l": "0013-9351"}, "abstract": "We assessed the relation between Covid-19 waves in Italy, which was severely affected during the pandemic. We evaluated the hypothesis that a larger impact from the first wave (February-March 2020) predicts a smaller peak during the second wave (September-October), in the absence of local changes in public health interventions and area-specific differences in time trends of environmental parameters. Based on publicly available data on province-specific SARS-CoV-2 infections and both crude and multivariable cubic spline regression models, we found that for provinces with the lowest incidence rates in the first wave, the incidence in the second wave increased roughly in proportion with the incidence in the first wave until an incidence of about 500-600 cases/100,000 in the first wave. Above that value, provinces with higher incidences in the first wave experienced lower incidences in the second wave. It appears that a comparatively high cumulative incidence of infection, even if far below theoretical thresholds required for herd immunity, may provide noticeable protection during the second wave. We speculate that, if real, the mechanism for this pattern could be depletion of most susceptible individuals and of superspreaders in the first wave. A population learning effect regarding cautious behavior could have also contributed. Since no area-specific variation of the national policy against the SARS-CoV-2 outbreak was allowed until early November 2020, neither individual behaviours nor established or purported environmental risk factors of Covid-19, such as air pollution and meteorological factors, are likely to have confounded the inverse trends we observed in infection incidence over time.", "doi": "10.1016/j.envres.2021.111097", "pmid": "33811866", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0013-9351(21)00391-1"}], "notes": [], "created": "2021-04-06T10:11:10.599Z", "modified": "2021-04-06T10:11:10.610Z"}, {"entity": "publication", "iuid": "9951948df6af47d19567e1e5335019c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9951948df6af47d19567e1e5335019c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9951948df6af47d19567e1e5335019c5"}}, "title": "Report from the CVOT Summit 2020: new cardiovascular and renal outcomes.", "authors": [{"family": "Schnell", "given": "Oliver", "initials": "O"}, {"family": "Cos", "given": "Xavier", "initials": "X"}, {"family": "Cosentino", "given": "Francesco", "initials": "F"}, {"family": "Forst", "given": "Thomas", "initials": "T"}, {"family": "Giorgino", "given": "Francesco", "initials": "F"}, {"family": "Heersprink", "given": "Hiddo J L", "initials": "HJL"}, {"family": "Kosiborod", "given": "Mikhail", "initials": "M"}, {"family": "Wanner", "given": "Christoph", "initials": "C"}, {"family": "Standl", "given": "Eberhard", "initials": "E"}], "type": "editorial", "published": "2021-03-31", "journal": {"title": "Cardiovasc Diabetol", "issn": "1475-2840", "volume": "20", "issue": "1", "pages": "75", "issn-l": null}, "abstract": "The 6th Cardiovascular Outcome Trial (CVOT) Summit \"Cardiovascular and Renal Outcomes 2020\" was the first to be held virtually on October 29-30, 2020. As in previous years, this summit served as reference meeting for in-depth discussions on the topic of recently completed and presented major outcome trials. This year, focus was placed on the outcomes of VERTIS-CV, EMPEROR-Reduced, DAPA-CKD, and FIDELIO-DKD. Trial implications for diabetes management and the impact on new treatment algorithms were highlighted for diabetologists, cardiologists, endocrinologists, nephrologists, and general practitioners. Discussion evolved from major outcome trials using SGLT-2 inhibitors for treatment and prevention of heart failure and chronic kidney disease in people with and without diabetes, to additional therapy options for chronic kidney disease with a novel mineralocorticoid receptor antagonist. Furthermore, challenges in diabetes management like COVID-19 and obesity, as well as novel treatment strategies and guidelines, were discussed.The 7th Cardiovascular Outcome Trial Summit will be held virtually on November, 18-19, 2021 ( http://www.cvot.org ).", "doi": "10.1186/s12933-021-01254-1", "pmid": "33789663", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12933-021-01254-1"}, {"db": "pmc", "key": "PMC8010779"}], "notes": [], "created": "2021-04-06T10:39:05.268Z", "modified": "2021-04-06T10:39:05.290Z"}, {"entity": "publication", "iuid": "a0636447716b4b328bbc5bd67a94da12", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a0636447716b4b328bbc5bd67a94da12.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a0636447716b4b328bbc5bd67a94da12"}}, "title": "Immunotherapy may protect cancer patients from SARS-CoV-2 infection: a single-center retrospective analysis.", "authors": [{"family": "Isgr\u00f2", "given": "Maria Antonietta", "initials": "MA"}, {"family": "Vitale", "given": "Maria Grazia", "initials": "MG"}, {"family": "Celentano", "given": "Egidio", "initials": "E"}, {"family": "Nocerino", "given": "Flavia", "initials": "F"}, {"family": "Porciello", "given": "Giuseppe", "initials": "G"}, {"family": "Curvietto", "given": "Marcello", "initials": "M"}, {"family": "Mallardo", "given": "Domenico", "initials": "D"}, {"family": "Montagnese", "given": "Concetta", "initials": "C"}, {"family": "Russo", "given": "Luigi", "initials": "L"}, {"family": "Zanaletti", "given": "Nicoletta", "initials": "N"}, {"family": "Avallone", "given": "Antonio", "initials": "A"}, {"family": "Pensabene", "given": "Matilde", "initials": "M"}, {"family": "De Laurentiis", "given": "Michelino", "initials": "M"}, {"family": "Centonze", "given": "Sara", "initials": "S"}, {"family": "Pignata", "given": "Sandro", "initials": "S"}, {"family": "Cannella", "given": "Lucia", "initials": "L"}, {"family": "Morabito", "given": "Alessandro", "initials": "A"}, {"family": "Caponigro", "given": "Francesco", "initials": "F"}, {"family": "Botti", "given": "Gerardo", "initials": "G"}, {"family": "Masucci", "given": "Giuseppe Valentino", "initials": "GV"}, {"family": "Giannarelli", "given": "Diana", "initials": "D"}, {"family": "Cavalcanti", "given": "Ernesta", "initials": "E"}, {"family": "Ascierto", "given": "Paolo Antonio", "initials": "PA"}], "type": "journal article", "published": "2021-03-31", "journal": {"title": "J Transl Med", "issn": "1479-5876", "volume": "19", "issue": "1", "pages": "132", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) global pandemic has created unique challenges to healthcare systems throughout the world. Ensuring subjects' safety is mandatory especially in oncology, in consideration of cancer patients' particular frailty. We examined the proportion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgM and/or IgG positive subjects in three different groups from Istituto Nazionale Tumori - IRCCS \"Fondazione G. Pascale\" in Naples (Campania region, Italy): cancer patients treated with Innovative Immunotherapy (Immune Checkpoint Inhibitors, ICIs), cancer patients undergoing standard Chemotherapies (CHTs) and healthcare providers. 9 out of 287 (3.1%) ICIs patients resulted positive, with a significant lower percentage in respect to CHTs patients (39 positive subjects out of 598, 6.5%) (p = 0.04). There was no statistically significant difference between ICIs cohort and healthcare providers, 48 out of 1050 resulting positive (4.6%). Performing a Propensity Score Matching based on gender and tumor stage, the effect of treatment on seropositivity was analyzed through a regression logistic model and the ICIs treatment resulted to be the only protective factor significantly (p = 0.03) associated with positivity (odds ratio-OR: 0.41; 95% confidence interval-CI 0.18-0.91). According to these preliminary data, ICIs would appear to be a protective factor against the onset of COVID-19 infection.", "doi": "10.1186/s12967-021-02798-2", "pmid": "33789686", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12967-021-02798-2"}, {"db": "pmc", "key": "PMC8010485"}], "notes": [], "created": "2021-04-06T10:44:34.189Z", "modified": "2021-04-06T10:45:15.550Z"}, {"entity": "publication", "iuid": "bc41bcd6a843474c8beee260d5a0ed27", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bc41bcd6a843474c8beee260d5a0ed27.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bc41bcd6a843474c8beee260d5a0ed27"}}, "title": "Household food insecurity and its association with self-reported male perpetration of intimate partner violence: a survey of two districts in central and western Uganda.", "authors": [{"family": "Awungafac", "given": "George", "initials": "G"}, {"family": "Mugamba", "given": "Stephen", "initials": "S"}, {"family": "Nalugoda", "given": "Fred", "initials": "F"}, {"family": "Sj\u00f6land", "given": "Carl Fredrik", "initials": "CF"}, {"family": "Kigozi", "given": "Godfrey", "initials": "G"}, {"family": "Rautiainen", "given": "Susanne", "initials": "S"}, {"family": "Malyabe", "given": "Robert Bulamba", "initials": "RB"}, {"family": "Ziegel", "given": "Leo", "initials": "L"}, {"family": "Nakigozi", "given": "Gertrude", "initials": "G"}, {"family": "Nalwoga", "given": "Grace Kigozi", "initials": "GK"}, {"family": "Kyasanku", "given": "Emmanuel", "initials": "E"}, {"family": "Nkale", "given": "James", "initials": "J"}, {"family": "Watya", "given": "Stephen", "initials": "S"}, {"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM"}, {"family": "K\u00e5gesten", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2021-03-31", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "3", "pages": "e045427"}, "abstract": "This study aimed to determine the lifetime prevalence of male-perpetrated intimate partner violence (IPV), and to assess the association with food insecurity, sociodemographic factors and health risk behaviours in Uganda in the year preceding COVID-19-associated lockdowns.\r\n\r\nPopulation-based, cross-sectional household survey.\r\n\r\nUrban, semiurban and rural communities of the Wakiso and Hoima districts in Uganda.\r\n\r\nA total of N=2014 males aged 13-80 years participated in the survey. The current study included males who reported having ever been in a sexual union and responded to the IPV questions (N=1314).\r\n\r\nData were collected face-to-face from May 2018 to July 2019 using an interviewer-mediated questionnaire. Lifetime IPV perpetration was measured as 'no physical and/or sexual IPV', 'physical' versus 'sexual violence only', and 'physical and sexual violence'. Past-year food insecurity was measured through the Food Insecurity Experience Scale and categorised into 'none', 'low' and 'high'. Multinomial logistic regression was used to determine the crude and adjusted relative risk ratios (aRRRs) of IPV perpetration in relation to self-reported food insecurity, adjusting for sociodemographic and health risk behaviours.\r\n\r\nThe prevalence of self-reported lifetime IPV perpetration was 14.6% for physical and 6.5% for sexual violence, while 5.3% reported to have perpetrated both physical and sexual IPV. Most (75.7%) males reported no food insecurity, followed by low (20.7%) and high (3.6%) food insecurity. In adjusted models, food insecurity was associated with increased risk of having perpetrated both physical and sexual violence (aRRR=2.57, 95% CI 1.52 to 4.32). IPV perpetration was also independently associated with having had more than one lifetime sexual partner and drinking alcohol, but not with education level or religion.\r\n\r\nThis study suggests that food insecurity is associated with male IPV perpetration, and more efforts are needed to prevent and mitigate the expected worsening of this situation as a result of the COVID-19 pandemic.", "doi": "10.1136/bmjopen-2020-045427", "pmid": "33789856", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-045427"}], "notes": [], "created": "2021-04-06T10:43:45.278Z", "modified": "2021-06-18T15:49:13.890Z"}, {"entity": "publication", "iuid": "b1cbf1dcbb51410d9addeac7af4e00a3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1cbf1dcbb51410d9addeac7af4e00a3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1cbf1dcbb51410d9addeac7af4e00a3"}}, "title": "A longitudinal assessment of depression and anxiety in the Republic of Ireland before and during the COVID-19 pandemic.", "authors": [{"family": "Hyland", "given": "Philip", "initials": "P"}, {"family": "Shevlin", "given": "Mark", "initials": "M"}, {"family": "Murphy", "given": "Jamie", "initials": "J"}, {"family": "McBride", "given": "Orla", "initials": "O"}, {"family": "Fox", "given": "Robert", "initials": "R"}, {"family": "Bondjers", "given": "Kristina", "initials": "K"}, {"family": "Karatzias", "given": "Thanos", "initials": "T"}, {"family": "Bentall", "given": "Richard P", "initials": "RP"}, {"family": "Martinez", "given": "Anton", "initials": "A"}, {"family": "Valli\u00e8res", "given": "Fr\u00e9d\u00e9rique", "initials": "F"}], "type": "journal article", "published": "2021-03-31", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "issn-l": null, "volume": "300", "issue": null, "pages": "113905"}, "abstract": "Few studies have examined changes in mental health before and after the outbreak of COVID-19. We examined changes in the prevalence of major depression and generalized anxiety disorder (GAD) between February 2019 and March-April 2020; if there were changes in major depression and GAD during six weeks of nationwide lockdown; and we identified factors that predicted major depression and GAD across the six-week lockdown period. Nationally representative samples of Irish adults were gathered using identical methods in February 2019 (N = 1020) and March-April 2020 (N = 1041). The latter was reassessed six weeks later. Significantly more people screened positive for depression in February 2019 (29.8% 95% CI = 27.0, 32.6) than in March-April 2020 (22.8% 95% CI = 20.2, 25.3), and there was no change in GAD. There were no significant changes in depression and GAD during the lockdown. Major depression was predicted by younger age, non-city dwelling, lower resilience, higher loneliness, and higher somatic problems. GAD was predicted by a broader set of variables including several COVID-19 specific variables. These findings indicate that the prevalence of major depression and GAD did not increase as a result of, or during the early phase of the COVID-19 pandemic in Ireland.", "doi": "10.1016/j.psychres.2021.113905", "pmid": "33827013", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(21)00202-X"}], "notes": [], "created": "2021-04-09T16:39:06.688Z", "modified": "2021-06-18T15:49:45.988Z"}, {"entity": "publication", "iuid": "6ed7d515b54b4351a8752f9debe15ad5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ed7d515b54b4351a8752f9debe15ad5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ed7d515b54b4351a8752f9debe15ad5"}}, "title": "Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials.", "authors": [{"family": "Jolliffe", "given": "David A", "initials": "DA"}, {"family": "Camargo", "given": "Carlos A", "initials": "CA"}, {"family": "Sluyter", "given": "John D", "initials": "JD"}, {"family": "Aglipay", "given": "Mary", "initials": "M"}, {"family": "Aloia", "given": "John F", "initials": "JF"}, {"family": "Ganmaa", "given": "Davaasambuu", "initials": "D"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Bischoff-Ferrari", "given": "Heike A", "initials": "HA"}, {"family": "Borzutzky", "given": "Arturo", "initials": "A"}, {"family": "Damsgaard", "given": "Camilla T", "initials": "CT"}, {"family": "Dubnov-Raz", "given": "Gal", "initials": "G"}, {"family": "Esposito", "given": "Susanna", "initials": "S"}, {"family": "Gilham", "given": "Clare", "initials": "C"}, {"family": "Ginde", "given": "Adit A", "initials": "AA"}, {"family": "Golan-Tripto", "given": "Inbal", "initials": "I"}, {"family": "Goodall", "given": "Emma C", "initials": "EC"}, {"family": "Grant", "given": "Cameron C", "initials": "CC"}, {"family": "Griffiths", "given": "Christopher J", "initials": "CJ"}, {"family": "Hibbs", "given": "Anna Maria", "initials": "AM"}, {"family": "Janssens", "given": "Wim", "initials": "W"}, {"family": "Khadilkar", "given": "Anuradha Vaman", "initials": "AV"}, {"family": "Laaksi", "given": "Ilkka", "initials": "I"}, {"family": "Lee", "given": "Margaret T", "initials": "MT"}, {"family": "Loeb", "given": "Mark", "initials": "M"}, {"family": "Maguire", "given": "Jonathon L", "initials": "JL"}, {"family": "Majak", "given": "Pawe\u0142", "initials": "P"}, {"family": "Mauger", "given": "David T", "initials": "DT"}, {"family": "Manaseki-Holland", "given": "Semira", "initials": "S"}, {"family": "Murdoch", "given": "David R", "initials": "DR"}, {"family": "Nakashima", "given": "Akio", "initials": "A"}, {"family": "Neale", "given": "Rachel E", "initials": "RE"}, {"family": "Pham", "given": "Hai", "initials": "H"}, {"family": "Rake", "given": "Christine", "initials": "C"}, {"family": "Rees", "given": "Judy R", "initials": "JR"}, {"family": "Rosendahl", "given": "Jenni", "initials": "J"}, {"family": "Scragg", "given": "Robert", "initials": "R"}, {"family": "Shah", "given": "Dheeraj", "initials": "D"}, {"family": "Shimizu", "given": "Yoshiki", "initials": "Y"}, {"family": "Simpson-Yap", "given": "Steve", "initials": "S"}, {"family": "Trilok-Kumar", "given": "Geeta", "initials": "G"}, {"family": "Urashima", "given": "Mitsuyoshi", "initials": "M"}, {"family": "Martineau", "given": "Adrian R", "initials": "AR"}], "type": "journal article", "published": "2021-03-30", "journal": {"title": "Lancet Diabetes Endocrinol", "issn": "2213-8595", "volume": null, "issue": null, "issn-l": null}, "abstract": "A 2017 meta-analysis of data from 25 randomised controlled trials (RCTs) of vitamin D supplementation for the prevention of acute respiratory infections (ARIs) revealed a protective effect of this intervention. We aimed to examine the link between vitamin D supplementation and prevention of ARIs in an updated meta-analysis.\n\nFor this systematic review and meta-analysis, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, and the ClinicalTrials.gov registry for studies listed from database inception to May 1, 2020. Double-blind RCTs of vitamin D 3, vitamin D2, or 25-hydroxyvitamin D (25[OH]D) supplementation for any duration, with a placebo or low-dose vitamin D control, were eligible if they had been approved by a research ethics committee, and if ARI incidence was collected prospectively and prespecified as an efficacy outcome. Studies reporting results of long-term follow-up of primary RCTs were excluded. Aggregated study-level data, stratified by baseline 25(OH)D concentration and age, were obtained from study authors. Using the proportion of participants in each trial who had one or more ARIs, we did a random-effects meta-analysis to obtain pooled odds ratios (ORs) and 95% CIs to estimate the effect of vitamin D supplementation on the risk of having one or more ARIs (primary outcome) compared with placebo. Subgroup analyses were done to estimate whether the effects of vitamin D supplementation on the risk of ARI varied according to baseline 25(OH)D concentration (<25 nmol/L vs 25\u00b70-49\u00b79 nmol/L vs 50\u00b70-74\u00b79 nmol/L vs >75\u00b70 nmol/L), vitamin D dose (daily equivalent of <400 international units [IU] vs 400-1000 IU vs 1001-2000 IU vs >2000 IU), dosing frequency (daily vs weekly vs once per month to once every 3 months), trial duration (\u226412 months vs >12 months), age at enrolment (<1\u00b700 years vs 1\u00b700-15\u00b799 years vs 16\u00b700-64\u00b799 years vs \u226565\u00b700 years), and presence versus absence of airway disease (ie, asthma only, COPD only, or unrestricted). Risk of bias was assessed with the Cochrane Collaboration Risk of Bias Tool. The study was registered with PROSPERO, CRD42020190633.\n\nWe identified 1528 articles, of which 46 RCTs (75 541 participants) were eligible. Data for the primary outcome were obtained for 48 488 (98\u00b71%) of 49 419 participants (aged 0-95 years) in 43 studies. A significantly lower proportion of participants in the vitamin D supplementation group had one or more ARIs (14 332 [61\u00b73%] of 23 364 participants) than in the placebo group (14 217 [62\u00b73%] of 22 802 participants), with an OR of 0\u00b792 (95% CI 0\u00b786-0\u00b799; 37 studies; I 2=35\u00b76%, pheterogeneity=0\u00b7018). No significant effect of vitamin D supplementation on the risk of having one or more ARIs was observed for any of the subgroups defined by baseline 25(OH)D concentration. However, protective effects of supplementation were observed in trials in which vitamin D was given in a daily dosing regimen (OR 0\u00b778 [95% CI 0\u00b765-0\u00b794]; 19 studies; I2=53\u00b75%, pheterogeneity=0\u00b7003), at daily dose equivalents of 400-1000 IU (0\u00b770 [0\u00b755-0\u00b789]; ten studies; I2=31\u00b72%, pheterogeneity=0\u00b716), for a duration of 12 months or less (0\u00b782 [0\u00b772-0\u00b793]; 29 studies; I2=38\u00b71%, pheterogeneity=0\u00b7021), and to participants aged 1\u00b700-15\u00b799 years at enrolment (0\u00b771 [0\u00b757-0\u00b790]; 15 studies; I2=46\u00b70%, pheterogeneity=0\u00b7027). No significant interaction between allocation to the vitamin D supplementation group versus the placebo group and dose, dose frequency, study duration, or age was observed. In addition, no significant difference in the proportion of participants who had at least one serious adverse event in the vitamin supplementation group compared with the placebo group was observed (0\u00b797 [0\u00b786-1\u00b707]; 36 studies; I2=0\u00b70%, pheterogeneity=0\u00b799). Risk of bias within individual studies was assessed as being low for all but three trials.\n\nDespite evidence of significant heterogeneity across trials, vitamin D supplementation was safe and overall reduced the risk of ARI compared with placebo, although the risk reduction was small. Protection was associated with administration of daily doses of 400-1000 IU for up to 12 months, and age at enrolment of 1\u00b700-15\u00b799 years. The relevance of these findings to COVID-19 is not known and requires further investigation.\n\nNone.", "doi": "10.1016/S2213-8587(21)00051-6", "pmid": "33798465", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2213-8587(21)00051-6"}], "notes": [], "created": "2021-04-06T10:40:59.319Z", "modified": "2021-04-06T10:40:59.341Z"}, {"entity": "publication", "iuid": "126cbe8fde8b4bebad2bee9b574f9e12", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/126cbe8fde8b4bebad2bee9b574f9e12.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/126cbe8fde8b4bebad2bee9b574f9e12"}}, "title": "The impact of viremia on organ failure, biomarkers and mortality in a Swedish cohort of critically ill COVID-19 patients.", "authors": [{"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Bergqvist", "given": "Anders", "initials": "A"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}], "type": "journal article", "published": "2021-03-30", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "7163"}, "abstract": "The spread of virus via the blood stream has been suggested to contribute to extra-pulmonary organ failure in Coronavirus disease 2019 (COVID-19). We assessed SARS-CoV-2 RNAemia (RNAemia) and the association between RNAemia and inflammation, organ failure and mortality in critically ill COVID-19 patients. We included all patients with PCR verified COVID-19 and consent admitted to ICU. SARS-CoV-2 RNA copies above 1000/ml measured by PCR in plasma was defined as RNAemia and used as surrogate for viremia. In this cohort of 92 patients 59 (64%) were invasively ventilated. RNAemia was found in 31 patients (34%). Hypertension and corticosteroid treatment was more common in patients with RNAemia. Extra-pulmonary organ failure biomarkers and the extent of organ failure were similar in patients with and without RNAemia, but the former group had more renal replacement therapy and higher mortality (26 vs 16%; 35 vs 16%, respectively, p = 0.04). RNAemia was not an independent predictor of death at 30 days after adjustment for age. SARS-CoV2 RNA copies in plasma is a common finding in ICU patients with COVID-19. Although viremia was not associated with extra pulmonary organ failure it was more common in patients who did not survive to 30 days after ICU admission.Trial registration: ClinicalTrials NCT04316884.", "doi": "10.1038/s41598-021-86500-y", "pmid": "33785784", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-021-86500-y"}, {"db": "pmc", "key": "PMC8010103"}, {"db": "ClinicalTrials.gov", "key": "NCT04316884"}], "notes": [], "created": "2021-04-09T16:26:36.852Z", "modified": "2021-06-11T14:14:53.671Z"}, {"entity": "publication", "iuid": "41e5af559a954cca92916b7c5903d08f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41e5af559a954cca92916b7c5903d08f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41e5af559a954cca92916b7c5903d08f"}}, "title": "Digital social entrepreneurship: the N-Helix response to stakeholders' COVID-19 needs.", "authors": [{"family": "Ib\u00e1\u00f1ez", "given": "Mar\u00eda J", "initials": "MJ"}, {"family": "Guerrero", "given": "Maribel", "initials": "M"}, {"family": "Y\u00e1\u00f1ez-Vald\u00e9s", "given": "Claudia", "initials": "C"}, {"family": "Barros-Celume", "given": "Sebasti\u00e1n", "initials": "S"}], "type": "journal article", "published": "2021-03-30", "journal": {"title": "J Technol Transf", "issn": "0892-9912", "volume": null, "issue": null, "pages": "1-24", "issn-l": null}, "abstract": "This study explores the emergence of a new entrepreneurship phenomenon (digital social entrepreneurship) as a result of the collaboration among many agents (N-Helix), given the government's limited capacity to respond to the stakeholders' needs satisfaction related to an exogenous event (e.g., the COVID-19 pandemic). Our theory development is based on three ongoing academic debates related to (a) the unrepresentativeness of the stakeholder theory in entrepreneurship research; (b) the emergence of digital social entrepreneurship (DSE) as a bridge between stakeholders' needs, socio-economic actors, and digital-social initiatives; and (c) the role of N-Helix collaborations to facilitate the emergence of global knowledge-intensive initiatives and the rapid adoptions of open innovations. Our results support our assumptions about the positive mediation effect of DSE in the relationship between N-Helix collaborations and stakeholders' satisfaction. Notably, results show how pandemic has intensified these relationships and how DSE in N-Helix collaborations can generate social impacts globally. Some implications for policy-makers have emerged from our results that should be considered during/post-COVID-19 pandemic.", "doi": "10.1007/s10961-021-09855-4", "pmid": "33814697", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "9855"}, {"db": "pmc", "key": "PMC8007451"}], "notes": [], "created": "2021-04-06T10:05:31.670Z", "modified": "2021-04-06T10:05:31.694Z"}, {"entity": "publication", "iuid": "23537200a18d4363813fcb1d9bc99ad4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23537200a18d4363813fcb1d9bc99ad4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23537200a18d4363813fcb1d9bc99ad4"}}, "title": "A patient satisfaction survey and educational package to improve the care of people hospitalised with COVID-19: an observational study, Liverpool, UK", "authors": [{"family": "Ahmed", "given": "Muhammad Shamsher", "initials": "MS"}, {"family": "Hicks", "given": "Scott Rory", "initials": "SR"}, {"family": "Watson", "given": "Rebecca", "initials": "R"}, {"family": "Ahmed", "given": "Rajia Akter", "initials": "RA"}, {"family": "Jones", "given": "Lewis", "initials": "L"}, {"family": "Vaselli", "given": "Marcella", "initials": "M"}, {"family": "Wu", "given": "Meng San", "initials": "MS"}, {"family": "Hayat", "given": "Fatima", "initials": "F"}, {"family": "Ratcliffe", "given": "Libuse", "initials": "L"}, {"family": "McKenna", "given": "Mark", "initials": "M"}, {"family": "Hine", "given": "Paul", "initials": "P"}, {"family": "Defres", "given": "Sylviane", "initials": "S"}, {"family": "Wingfield", "given": "Tom", "initials": "T"}], "type": "posted-content", "published": "2021-03-30", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.23.21253630", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-03-31T08:19:04.466Z", "modified": "2021-04-07T10:24:37.804Z"}, {"entity": "publication", "iuid": "9ccdc15ea88a46639b096f5aaabaf24f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ccdc15ea88a46639b096f5aaabaf24f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ccdc15ea88a46639b096f5aaabaf24f"}}, "title": "Sexual health (excluding reproductive health, intimate partner violence and gender-based violence) and COVID-19: a scoping review.", "authors": [{"family": "Kumar", "given": "Navin", "initials": "N"}, {"family": "Janmohamed", "given": "Kamila", "initials": "K"}, {"family": "Nyhan", "given": "Kate", "initials": "K"}, {"family": "Forastiere", "given": "Laura", "initials": "L"}, {"family": "Zhang", "given": "Wei-Hong", "initials": "WH"}, {"family": "K\u00e5gesten", "given": "Anna", "initials": "A"}, {"family": "Uhlich", "given": "Maximiliane", "initials": "M"}, {"family": "Sarpong Frimpong", "given": "Afia", "initials": "A"}, {"family": "Van de Velde", "given": "Sarah", "initials": "S"}, {"family": "Francis", "given": "Joel M", "initials": "JM"}, {"family": "Erausquin", "given": "Jennifer Toller", "initials": "JT"}, {"family": "Larrson", "given": "Elin", "initials": "E"}, {"family": "Callander", "given": "Deton", "initials": "D"}, {"family": "Scott", "given": "John", "initials": "J"}, {"family": "Minichiello", "given": "Victor", "initials": "V"}, {"family": "Tucker", "given": "Joseph", "initials": "J"}], "type": "journal article", "published": "2021-03-29", "journal": {"title": "Sex Transm Infect", "issn": "1472-3263", "volume": null, "issue": null, "issn-l": "1368-4973"}, "abstract": "The COVID-19 pandemic has exposed and exacerbated existing socioeconomic and health disparities, including disparities in sexual health and well-being. While there have been several reviews published on COVID-19 and population health disparities generally-including some with attention to HIV-none has focused on sexual health (ie, STI care, female sexual health, sexual behaviour). We have conducted a scoping review focused on sexual health (excluding reproductive health (RH), intimate partner violence (IPV) and gender-based violence (GBV)) in the COVID-19 era, examining sexual behaviours and sexual health outcomes.\n\nA scoping review, compiling both peer-reviewed and grey literature, focused on sexual health (excluding RH, IPV and GBV) and COVID-19 was conducted on 15 September 2020. Multiple bibliographical databases were searched. Study selection conformed to Joanna Briggs Institute (JBI) Reviewers' Manual 2015 Methodology for JBI Scoping Reviews. We only included English-language original studies.\n\nWe found that men who have sex with men may be moving back toward pre-pandemic levels of sexual activity, and that STI and HIV testing rates seem to have decreased. There was minimal focus on outcomes such as the economic impact on sexual health (excluding RH, IPV and GBV) and STI care, especially STI care of marginalised populations. In terms of population groups, there was limited focus on sex workers or on women, especially women's sexual behaviour and mental health. We noticed limited use of qualitative techniques. Very few studies were in low/middle-income countries (LMICs).\n\nSexual health research is critical during a global infectious disease pandemic and our review of studies suggested notable research gaps. Researchers can focus efforts on LMICs and under-researched topics within sexual health and explore the use of qualitative techniques and interventions where appropriate.", "doi": "10.1136/sextrans-2020-054896", "pmid": "33782145", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "sextrans-2020-054896"}], "notes": [], "created": "2021-03-31T08:14:48.949Z", "modified": "2021-04-23T16:12:40.581Z"}, {"entity": "publication", "iuid": "bdfac6c6a319440bb5a4d00d0851a5fe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bdfac6c6a319440bb5a4d00d0851a5fe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bdfac6c6a319440bb5a4d00d0851a5fe"}}, "title": "Key considerations on the potential impacts of the COVID-19 pandemic on antimicrobial resistance research and surveillance.", "authors": [{"family": "Rodr\u00edguez-Ba\u00f1o", "given": "Jes\u00fas", "initials": "J"}, {"family": "Rossolini", "given": "Gian Maria", "initials": "GM"}, {"family": "Schultsz", "given": "Constance", "initials": "C"}, {"family": "Tacconelli", "given": "Evelina", "initials": "E"}, {"family": "Murthy", "given": "Srinivas", "initials": "S"}, {"family": "Ohmagari", "given": "Norio", "initials": "N"}, {"family": "Holmes", "given": "Alison", "initials": "A"}, {"family": "Bachmann", "given": "Till", "initials": "T"}, {"family": "Goossens", "given": "Herman", "initials": "H"}, {"family": "Canton", "given": "Rafael", "initials": "R"}, {"family": "Roberts", "given": "Adam P", "initials": "AP"}, {"family": "Henriques-Normark", "given": "Birgitta", "initials": "B"}, {"family": "Clancy", "given": "Cornelius J", "initials": "CJ"}, {"family": "Huttner", "given": "Benedikt", "initials": "B"}, {"family": "Fagerstedt", "given": "Patriq", "initials": "P"}, {"family": "Lahiri", "given": "Shawon", "initials": "S"}, {"family": "Kaushic", "given": "Charu", "initials": "C"}, {"family": "Hoffman", "given": "Steven J", "initials": "SJ"}, {"family": "Warren", "given": "Margo", "initials": "M"}, {"family": "Zoubiane", "given": "Ghada", "initials": "G"}, {"family": "Essack", "given": "Sabiha", "initials": "S"}, {"family": "Laxminarayan", "given": "Ramanan", "initials": "R"}, {"family": "Plant", "given": "Laura", "initials": "L"}], "type": "journal article", "published": "2021-03-27", "journal": {"title": "Trans R Soc Trop Med Hyg", "issn": "1878-3503", "volume": null, "issue": null, "issn-l": null}, "abstract": "Antibiotic use in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients during the COVID-19 pandemic has exceeded the incidence of bacterial coinfections and secondary infections, suggesting inappropriate and excessive prescribing. Even in settings with established antimicrobial stewardship (AMS) programmes, there were weaknesses exposed regarding appropriate antibiotic use in the context of the pandemic. Moreover, antimicrobial resistance (AMR) surveillance and AMS have been deprioritised with diversion of health system resources to the pandemic response. This experience highlights deficiencies in AMR containment and mitigation strategies that require urgent attention from clinical and scientific communities. These include the need to implement diagnostic stewardship to assess the global incidence of coinfections and secondary infections in COVID-19 patients, including those by multidrug-resistant pathogens, to identify patients most likely to benefit from antibiotic treatment and identify when antibiotics can be safely withheld, de-escalated or discontinued. Long-term global surveillance of clinical and societal antibiotic use and resistance trends is required to prepare for subsequent changes in AMR epidemiology, while ensuring uninterrupted supply chains and preventing drug shortages and stock outs. These interventions present implementation challenges in resource-constrained settings, making a case for implementation research on AMR. Knowledge and support for these practices will come from internationally coordinated, targeted research on AMR, supporting the preparation for future challenges from emerging AMR in the context of the current COVID-19 pandemic or future pandemics.", "doi": "10.1093/trstmh/trab048", "pmid": "33772597", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "6195536"}], "notes": [], "created": "2021-03-29T09:28:58.612Z", "modified": "2021-03-29T09:28:58.622Z"}, {"entity": "publication", "iuid": "b41b8b76a4534c3e81ce1b931d5bd041", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b41b8b76a4534c3e81ce1b931d5bd041.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b41b8b76a4534c3e81ce1b931d5bd041"}}, "title": "What must be done to tackle vaccine hesitancy and barriers to COVID-19 vaccination in migrants?", "authors": [{"family": "Crawshaw", "given": "Alison F", "initials": "AF"}, {"family": "Deal", "given": "Anna", "initials": "A"}, {"family": "Rustage", "given": "Kieran", "initials": "K"}, {"family": "Forster", "given": "Alice S", "initials": "AS"}, {"family": "Campos-Matos", "given": "Ines", "initials": "I"}, {"family": "Vandrevala", "given": "Tushna", "initials": "T"}, {"family": "W\u00fcrz", "given": "Andrea", "initials": "A"}, {"family": "Pharris", "given": "Anastasia", "initials": "A"}, {"family": "Suk", "given": "Jonathan", "initials": "J"}, {"family": "Kinsman", "given": "John", "initials": "J"}, {"family": "Deogan", "given": "Charlotte", "initials": "C"}, {"family": "Miller", "given": "Anna", "initials": "A"}, {"family": "Declich", "given": "Silvia", "initials": "S"}, {"family": "Greenaway", "given": "Chris", "initials": "C"}, {"family": "Noori", "given": "Teymur", "initials": "T"}, {"family": "Hargreaves", "given": "Sally", "initials": "S"}], "type": "journal article", "published": "2021-03-26", "journal": {"title": "J Travel Med", "issn": "1708-8305", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1093/jtm/taab048", "pmid": "33772312", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6189154"}], "notes": [], "created": "2021-03-29T09:27:31.563Z", "modified": "2021-06-18T15:45:53.420Z"}, {"entity": "publication", "iuid": "6fa79dbdcf4a48edaf5018baab0e0286", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6fa79dbdcf4a48edaf5018baab0e0286.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6fa79dbdcf4a48edaf5018baab0e0286"}}, "title": "The COVID-19 Epidemic: Management and Outcomes of Hemodialysis and Peritoneal Dialysis Patients in Stockholm, Sweden.", "authors": [{"family": "Smolander", "given": "Jessica", "initials": "J"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}], "type": "news", "published": "2021-03-26", "journal": {"title": "Kidney Blood Press Res", "issn": "1423-0143", "volume": "46", "issue": "2", "pages": "1-7", "issn-l": null}, "abstract": "The COVID-19 outbreak has been associated with a high morbidity, mortality, and a risk of long-term sequelae, and patients with severe COVID-19 are at increased risk of acute kidney injury. CKD patients are at high risk of being exposed to COVID-19 and suffer complications and poor outcome. In Sweden, mitigation strategies did not include lockdown. During March-April of 2020, wide-spread infection occurred in Stockholm.\n\nManagement and outcomes in forty hemodialysis (HD) patients and 4 peritoneal dialysis (PD) patients, with symptomatic COVID-19 in greater Stockholm during March and April of 2020 are reported.\n\nTwenty-four HD patients (60%) required medical care and hospitalization, whereas 16 patients (40%) were treated at home. Nine patients died (mortality rate of 22.5%), of whom 8 were men. The median age in non-survivors (78 years) was significantly higher than in survivors (p = 0.003). The median time in dialysis (11.5 years) was also significantly longer in non-survivors (p = 0.01). C-reactive protein (CRP) at diagnosis in 7 of non-survivors (median 213 mg/L, range 86-329 mg/L) was significantly higher than the CRP in 25 survivors (median 87 mg/L, range 1-328 mg/L) (p = 0.0003). Maximum CRP also indicated poorer outcome among hospitalized patients (p = 0.0004). The gender imbalance was striking with only men dying apart from 1 elderly woman. Only 4 PD patients were hospitalized with symptomatic COVID-19. One patient died, 2 were discharged, and 1 was treated at the intensive care unit and survived.\n\nHD patients >70 years were reported with longer dialysis vintage, higher CRP, and males were at an increased risk of dying from COVID-19, whereas those <70 years seemed to have a milder disease. Mitigation strategies to reduce rates of infection in high-risk populations remain essential. Follow-up focusing on long-term prognosis for extrapulmonary manifestations is likely to be important also in dialysis patients.", "doi": "10.1159/000514268", "pmid": "33774645", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "000514268"}], "notes": [], "created": "2021-03-29T09:30:38.838Z", "modified": "2021-04-28T18:08:47.789Z"}, {"entity": "publication", "iuid": "76bcc47259e5489c80a8c7107c73db6d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76bcc47259e5489c80a8c7107c73db6d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76bcc47259e5489c80a8c7107c73db6d"}}, "title": "Pregnancy and risk of COVID-19", "authors": [{"family": "Magnus", "given": "Maria C", "initials": "MC"}, {"family": "Oakley", "given": "Laura", "initials": "L"}, {"family": "K. Gjessing", "given": "H\u00e5kon", "initials": "H"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}, {"family": "Engjom", "given": "Hilde M", "initials": "HM"}, {"family": "Macsali", "given": "Ferenc", "initials": "F"}, {"family": "Juliusson", "given": "Petur B", "initials": "PB"}, {"family": "Andersen", "given": "Anne Marie Nybo", "initials": "AMN"}, {"family": "H\u00e5berg", "given": "Siri E", "initials": "SE"}], "type": "posted-content", "published": "2021-03-26", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.22.21254090", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-03-31T08:17:27.439Z", "modified": "2021-06-09T19:20:53.081Z"}, {"entity": "publication", "iuid": "0be63deaa6a04dbd94018b9288d6658a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0be63deaa6a04dbd94018b9288d6658a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0be63deaa6a04dbd94018b9288d6658a"}}, "title": "Molecular detection of SARS-CoV-2 being challenged by virus variation and asymptomatic infection.", "authors": [{"family": "Jiang", "given": "Congshan", "initials": "C"}, {"family": "Li", "given": "Xiaowei", "initials": "X"}, {"family": "Ge", "given": "Changrong", "initials": "C"}, {"family": "Ding", "given": "Yuanyuan", "initials": "Y"}, {"family": "Zhang", "given": "Tao", "initials": "T"}, {"family": "Cao", "given": "Shuai", "initials": "S"}, {"family": "Meng", "given": "Liesu", "initials": "L"}, {"family": "Lu", "given": "Shemin", "initials": "S"}], "type": "journal article", "published": "2021-03-26", "journal": {"title": "J Pharm Anal", "issn": "2214-0883", "volume": null, "issue": null, "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) has been a pandemic for more than a year. With the expanding second wave of pandemic in winter, the continuous evolution of SARS-CoV-2 has brought new issues, including the significance of virus mutations in infection and the detection of asymptomatic infection. In this review, we firstly introduced several major SARS-CoV-2 mutations since the COVID-19 outbreak and then mentioned the widely used molecular detection techniques to diagnose COVID-19, primarily focusing on their strengths and limitations. We further discussed the effects of viral genetic variation and asymptomatic infection on the molecular detection of SARS-CoV-2 infection. The review finally summarized useful insights into the molecular diagnosis of COVID-19 under the special situation challenging by virus mutation and asymptomatic infection.", "doi": "10.1016/j.jpha.2021.03.006", "pmid": "33815862", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2095-1779(21)00026-5"}, {"db": "pmc", "key": "PMC7997641"}], "notes": [], "created": "2021-04-06T10:04:49.143Z", "modified": "2021-04-06T10:04:49.166Z"}, {"entity": "publication", "iuid": "ff8aebe28e134ff58876ef8b0f4c1f82", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff8aebe28e134ff58876ef8b0f4c1f82.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff8aebe28e134ff58876ef8b0f4c1f82"}}, "title": "Impact of the COVID-19 Pandemic on Antimicrobial Resistance (AMR) Surveillance, Prevention and Control: A Global Survey", "authors": [{"family": "Tomczyk", "given": "Sara", "initials": "S"}, {"family": "Taylor", "given": "Angelina", "initials": "A"}, {"family": "Brown", "given": "Allison", "initials": "A"}, {"family": "Kraker", "given": "Marlieke de", "initials": "Md"}, {"family": "Eckmanns", "given": "Tim", "initials": "T"}, {"family": "El-Saed", "given": "Aiman", "initials": "A"}, {"family": "Alshamrani", "given": "Majid", "initials": "M"}, {"family": "Hendriksen", "given": "Rene", "initials": "R"}, {"family": "Jacob", "given": "Megan", "initials": "M"}, {"family": "L\u00f6fmark", "given": "Sonja", "initials": "S"}, {"family": "Perovic", "given": "Olga", "initials": "O"}, {"family": "Shetty", "given": "Nandini", "initials": "N"}, {"family": "Sievert", "given": "Dawn", "initials": "D"}, {"family": "Smith", "given": "Rachel", "initials": "R"}, {"family": "Stelling", "given": "John", "initials": "J"}, {"family": "Thakur", "given": "Siddhartha", "initials": "S"}, {"family": "Tornimbene", "given": "Barbara", "initials": "B"}, {"family": "Vietor", "given": "Ann Christin", "initials": "AC"}, {"family": "Eremin", "given": "Sergey", "initials": "S"}], "type": "posted-content", "published": "2021-03-26", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.24.21253807", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-03-31T08:21:46.157Z", "modified": "2021-04-07T10:24:52.698Z"}, {"entity": "publication", "iuid": "5cb6103efe2c4cde859dd9170a6cc94d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5cb6103efe2c4cde859dd9170a6cc94d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5cb6103efe2c4cde859dd9170a6cc94d"}}, "title": "Ultra-fast proteomics with Scanning SWATH.", "authors": [{"family": "Messner", "given": "Christoph B", "initials": "CB"}, {"family": "Demichev", "given": "Vadim", "initials": "V"}, {"family": "Bloomfield", "given": "Nic", "initials": "N"}, {"family": "Yu", "given": "Jason S L", "initials": "JSL"}, {"family": "White", "given": "Matthew", "initials": "M"}, {"family": "Kreidl", "given": "Marco", "initials": "M"}, {"family": "Egger", "given": "Anna-Sophia", "initials": "AS"}, {"family": "Freiwald", "given": "Anja", "initials": "A"}, {"family": "Ivosev", "given": "Gordana", "initials": "G"}, {"family": "Wasim", "given": "Fras", "initials": "F"}, {"family": "Zelezniak", "given": "Aleksej", "initials": "A"}, {"family": "J\u00fcrgens", "given": "Linda", "initials": "L"}, {"family": "Suttorp", "given": "Norbert", "initials": "N"}, {"family": "Sander", "given": "Leif Erik", "initials": "LE"}, {"family": "Kurth", "given": "Florian", "initials": "F"}, {"family": "Lilley", "given": "Kathryn S", "initials": "KS"}, {"family": "M\u00fclleder", "given": "Michael", "initials": "M"}, {"family": "Tate", "given": "Stephen", "initials": "S"}, {"family": "Ralser", "given": "Markus", "initials": "M"}], "type": "journal article", "published": "2021-03-25", "journal": {"title": "Nat Biotechnol", "issn": "1546-1696", "volume": null, "issue": null, "issn-l": null}, "abstract": "Accurate quantification of the proteome remains challenging for large sample series and longitudinal experiments. We report a data-independent acquisition method, Scanning SWATH, that accelerates mass spectrometric (MS) duty cycles, yielding quantitative proteomes in combination with short gradients and high-flow (800 \u00b5l min -1) chromatography. Exploiting a continuous movement of the precursor isolation window to assign precursor masses to tandem mass spectrometry (MS/MS) fragment traces, Scanning SWATH increases precursor identifications by ~70% compared to conventional data-independent acquisition (DIA) methods on 0.5-5-min chromatographic gradients. We demonstrate the application of ultra-fast proteomics in drug mode-of-action screening and plasma proteomics. Scanning SWATH proteomes capture the mode of action of fungistatic azoles and statins. Moreover, we confirm 43 and identify 11 new plasma proteome biomarkers of COVID-19 severity, advancing patient classification and biomarker discovery. Thus, our results demonstrate a substantial acceleration and increased depth in fast proteomic experiments that facilitate proteomic drug screens and clinical studies.", "doi": "10.1038/s41587-021-00860-4", "pmid": "33767396", "labels": {"Category: Proteins": null, "Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41587-021-00860-4"}, {"db": "URL", "key": "https://github.com/vdemichev/diann", "description": "Open-source algorithms made available through the DIA\u2013NN software suite"}, {"db": "URL", "key": "http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD023613", "description": "ProteomeXchange PXD023613: data generated for the benchmarks and the drug response screen in yeast"}], "notes": [], "created": "2021-03-29T09:19:46.825Z", "modified": "2021-04-23T16:13:04.586Z"}, {"entity": "publication", "iuid": "bf78c207136341c2905e9e118563642a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf78c207136341c2905e9e118563642a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf78c207136341c2905e9e118563642a"}}, "title": "Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts.", "authors": [{"family": "Molteni", "given": "Erika", "initials": "E", "orcid": "0000-0001-7773-8140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9aed1fbe444b48d4bfacb12050953c8e.json"}}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Magee", "given": "Laura A", "initials": "LA"}, {"family": "Murray", "given": "Benjamin", "initials": "B"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Gomez", "given": "Maria F", "initials": "MF"}, {"family": "Tsereteli", "given": "Neli", "initials": "N"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Brownstein", "given": "John S", "initials": "JS"}, {"family": "Davies", "given": "Richard", "initials": "R"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Spector", "given": "Tim D", "initials": "TD"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "Modat", "given": "Marc", "initials": "M"}], "type": "journal article", "published": "2021-03-25", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "6928"}, "abstract": "We tested whether pregnant and non-pregnant women differ in COVID-19 symptom profile and severity, and we extended previous investigations on hospitalized pregnant women to those who did not require hospitalization. Two female community-based cohorts (18-44 years) provided longitudinal (smartphone application, N = 1,170,315, n = 79 pregnant tested positive) and cross-sectional (web-based survey, N = 1,344,966, n = 134 pregnant tested positive) data, prospectively collected through self-participatory citizen surveillance in UK, Sweden and USA. Pregnant and non-pregnant were compared for frequencies of events, including SARS-CoV-2 testing, symptoms and hospitalization rates. Multivariable regression was used to investigate symptoms severity and comorbidity effects. Pregnant and non-pregnant women positive for SARS-CoV-2 infection were not different in syndromic severity, except for gastrointestinal symptoms. Pregnant were more likely to have received testing, despite reporting fewer symptoms. Pre-existing lung disease was most closely associated with syndromic severity in pregnant hospitalized. Heart and kidney diseases and diabetes increased risk. The most frequent symptoms among non-hospitalized women were anosmia [63% pregnant, 92% non-pregnant] and headache [72%, 62%]. Cardiopulmonary symptoms, including persistent cough [80%] and chest pain [73%], were more frequent among pregnant who were hospitalized. Consistent with observations in non-pregnant populations, lung disease and diabetes were associated with increased risk of more severe SARS-CoV-2 infection during pregnancy.", "doi": "10.1038/s41598-021-86452-3", "pmid": "33767292", "labels": {"Funder: Hj\u00e4rt-Lungfonden": null, "Category: Public Health": null, "Type: Journal article": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC7994587"}, {"db": "pii", "key": "10.1038/s41598-021-86452-3"}], "notes": [], "created": "2021-03-29T09:18:57.274Z", "modified": "2023-06-19T15:07:30.522Z"}, {"entity": "publication", "iuid": "0d40115030b14f5a86f99e3945d1643a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d40115030b14f5a86f99e3945d1643a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d40115030b14f5a86f99e3945d1643a"}}, "title": "Site-Specific O-Glycosylation Analysis of SARS-CoV-2 Spike Protein Produced in Insect and Human Cells.", "authors": [{"family": "Bagdonaite", "given": "Ieva", "initials": "I"}, {"family": "Thompson", "given": "Andrew J", "initials": "AJ"}, {"family": "Wang", "given": "Xiaoning", "initials": "X"}, {"family": "S\u00f8gaard", "given": "Max", "initials": "M"}, {"family": "Fougeroux", "given": "Cyrielle", "initials": "C"}, {"family": "Frank", "given": "Martin", "initials": "M"}, {"family": "Diedrich", "given": "Jolene K", "initials": "JK"}, {"family": "Yates", "given": "John R", "initials": "JR"}, {"family": "Salanti", "given": "Ali", "initials": "A"}, {"family": "Vakhrushev", "given": "Sergey Y", "initials": "SY"}, {"family": "Paulson", "given": "James C", "initials": "JC"}, {"family": "Wandall", "given": "Hans H", "initials": "HH"}], "type": "journal article", "published": "2021-03-25", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "4", "issn-l": "1999-4915"}, "abstract": "Enveloped viruses hijack not only the host translation processes, but also its glycosylation machinery, and to a variable extent cover viral surface proteins with tolerogenic host-like structures. SARS-CoV-2 surface protein S presents as a trimer on the viral surface and is covered by a dense shield of N-linked glycans, and a few O-glycosites have been reported. The location of O-glycans is controlled by a large family of initiating enzymes with variable expression in cells and tissues and hence is difficult to predict. Here, we used our well-established O-glycoproteomic workflows to map the precise positions of O-linked glycosylation sites on three different entities of protein S-insect cell or human cell-produced ectodomains, or insect cell derived receptor binding domain (RBD). In total 25 O-glycosites were identified, with similar patterns in the two ectodomains of different cell origin, and a distinct pattern of the monomeric RBD. Strikingly, 16 out of 25 O-glycosites were located within three amino acids from known N-glycosites. However, O-glycosylation was primarily found on peptides that were unoccupied by N-glycans, and otherwise had low overall occupancy. This suggests possible complementary functions of O-glycans in immune shielding and negligible effects of O-glycosylation on subunit vaccine design for SARS-CoV-2.", "doi": "10.3390/v13040551", "pmid": "33806155", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "v13040551"}], "notes": [], "created": "2021-04-06T10:35:44.200Z", "modified": "2021-04-06T10:35:44.209Z"}, {"entity": "publication", "iuid": "c6c8a24310104994be31f728755aa631", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c6c8a24310104994be31f728755aa631.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c6c8a24310104994be31f728755aa631"}}, "title": "COVID-19 Editorial: Mechanistic Links and Daunting Therapeutic Challenges for Metabolic Diseases One Year after The Beginning of The COVID-19 Pandemic.", "authors": [{"family": "Tessier", "given": "Christopher M", "initials": "CM"}, {"family": "Kokkinos", "given": "Alexander", "initials": "A"}, {"family": "Mingrone", "given": "Geltrude", "initials": "G"}, {"family": "Koliaki", "given": "Chrysi", "initials": "C"}, {"family": "Zierath", "given": "Juleen R", "initials": "JR"}, {"family": "Mantzoros", "given": "Christos S", "initials": "CS"}], "type": "editorial", "published": "2021-03-25", "journal": {"title": "Metabolism", "issn": "1532-8600", "volume": null, "issue": null, "pages": "154769", "issn-l": null}, "abstract": null, "doi": "10.1016/j.metabol.2021.154769", "pmid": "33775648", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0026-0495(21)00069-X"}], "notes": [], "created": "2021-03-30T12:15:01.308Z", "modified": "2021-03-30T12:15:01.324Z"}, {"entity": "publication", "iuid": "e1da34c615124871ae7119f2d1c31ada", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e1da34c615124871ae7119f2d1c31ada.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e1da34c615124871ae7119f2d1c31ada"}}, "title": "A Simple Model for the Total Number of SARS-CoV-2 Infections on a National Level", "authors": [{"family": "Blanco", "given": "N", "initials": "N"}, {"family": "Stafford", "given": "K", "initials": "K"}, {"family": "Lavoie", "given": "M C", "initials": "MC"}, {"family": "Brandenburg", "given": "A", "initials": "A"}, {"family": "G\u00f3rna", "given": "M W", "initials": "MW"}, {"family": "Merski", "given": "M", "initials": "M"}], "type": "journal-article", "published": "2021-03-25", "journal": {"title": "Epidemiol. Infect.", "issn": "0950-2688", "issn-l": null, "volume": null, "issue": null, "pages": "1-25"}, "abstract": null, "doi": "10.1017/s0950268821000649", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.5281/zenodo.4454173", "description": "Raw, original data and fits data set"}], "notes": [], "created": "2021-03-25T14:01:34.383Z", "modified": "2021-06-18T15:40:26.357Z"}, {"entity": "publication", "iuid": "609fc217e83b4e8891e131b5bf0bd9bc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/609fc217e83b4e8891e131b5bf0bd9bc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/609fc217e83b4e8891e131b5bf0bd9bc"}}, "title": "Impact of the COVID-19 pandemic on emergency and elective hip surgeries in Norway.", "authors": [{"family": "Magnusson", "given": "Karin", "initials": "K"}, {"family": "Helgeland", "given": "Jon", "initials": "J"}, {"family": "Gr\u00f8sland", "given": "Mari", "initials": "M"}, {"family": "Telle", "given": "Kjetil", "initials": "K"}], "type": "journal article", "published": "2021-03-24", "journal": {"title": "Acta Orthop", "issn": "1745-3682", "issn-l": null, "volume": null, "issue": null, "pages": "1-5"}, "abstract": "Background and purpose - Many countries implemented strict lockdown policies to control the COVID-19 pandemic during March 2020. The impacts of lockdown policies on joint surgeries are unknown. Therefore, we assessed the effects of COVID-19 pandemic lockdown restrictions on the number of emergency and elective hip joint surgeries, and explored whether these procedures are more/less affected by lockdown restrictions than other hospital care.Patients and methods - In 1,344,355 persons aged \u2265 35 years in the Norwegian emergency preparedness (BEREDT C19) register, we studied the daily number of persons having (1) emergency surgeries due to hip fractures, and (2) electively planned surgeries due to hip osteoarthritis before and after COVID-19 lockdown restrictions were implemented nationally on March 13, 2020, for different age and sex groups. Incidence rate ratios (IRR) reflect the after-lockdown number of surgeries divided by the before-lockdown number of surgeries.Results - After-lockdown elective hip surgeries comprised one-third the number of before-lockdown (IRR \u223c0.3), which is a greater drop than that seen in all-cause elective hospital care (IRR \u223c0.6). Men aged 35-69 had half the number of emergency hip fracture surgeries (IRR \u223c0.6), whereas women aged \u2265 70 had the same number of emergency hip fracture surgeries after lockdown (IRR \u223c1). Only women aged 35-69 and men aged \u2265 70 had emergency hip fracture surgery rates after lockdown comparable to what may be expected based on analyses of all-cause acute care (IRR \u223c0.80)Interpretation - It is important to note for future pandemics management that lockdown restrictions may impact more on scheduled joint surgery than other scheduled hospital care. Lockdown may also impact the number of emergency joint surgeries for men aged \u2265 35 but not those for women aged \u2265 70.", "doi": "10.1080/17453674.2021.1898782", "pmid": "33757405", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-03-25T13:56:55.551Z", "modified": "2021-03-25T13:57:54.036Z"}, {"entity": "publication", "iuid": "dc56fd4c0afb439f9a943617cb5b418a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dc56fd4c0afb439f9a943617cb5b418a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dc56fd4c0afb439f9a943617cb5b418a"}}, "title": "Factors Associated with Emerging and Re-emerging of SARS-CoV-2 Variants", "authors": [{"family": "Spratt", "given": "Austin N", "initials": "AN"}, {"family": "Kannan", "given": "Saathvik R", "initials": "SR"}, {"family": "Woods", "given": "Lucas T", "initials": "LT"}, {"family": "Weisman", "given": "Gary A", "initials": "GA"}, {"family": "Quinn", "given": "Thomas P", "initials": "TP"}, {"family": "Lorson", "given": "Christian L", "initials": "CL"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}, {"family": "Singh", "given": "Kamal", "initials": "K"}], "type": "posted-content", "published": "2021-03-24", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.24.436850", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null}, "xrefs": [], "notes": [], "created": "2021-04-15T18:53:24.322Z", "modified": "2021-04-21T08:36:57.929Z"}, {"entity": "publication", "iuid": "ce949ddad1b34d3cba35a5f617b4f1bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ce949ddad1b34d3cba35a5f617b4f1bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ce949ddad1b34d3cba35a5f617b4f1bf"}}, "title": "Diverse SARS-CoV-2 variants preceded the initial COVID-19 outbreak in Croatia.", "authors": [{"family": "Roki\u0107", "given": "Filip", "initials": "F"}, {"family": "Trgovec-Greif", "given": "Lovro", "initials": "L"}, {"family": "Su\u010di\u0107", "given": "Neven", "initials": "N"}, {"family": "\u010cemelji\u0107", "given": "Noa", "initials": "N"}, {"family": "Grbe\u0161a", "given": "\u0110ur\u0111ica Cekinovi\u0107", "initials": "\u0110C"}, {"family": "Svedru\u017ei\u0107", "given": "\u017deljko", "initials": "\u017d"}, {"family": "Rukavina", "given": "Tomislav", "initials": "T"}, {"family": "Vugrek", "given": "Oliver", "initials": "O"}, {"family": "Jurak", "given": "Igor", "initials": "I"}], "type": "journal article", "published": "2021-03-24", "journal": {"title": "Arch Virol", "issn": "1432-8798", "volume": null, "issue": null, "issn-l": null}, "abstract": "We developed a next-generation SARS-CoV-2 sequencing platform and obtained the first SARS-CoV-2 sequences from patients in Croatia at the beginning of the COVID-19 outbreak in the spring of 2020. Integrating the sequencing and the epidemiological data, we show that patients were infected with different SARS-CoV-2 variants belonging to different clades (mostly G and GH). This result confirms that there was widespread virus transmission early in 2020. Interestingly, we identified a unique mutation resulting in a V13I substitution in Nsp5A, the main viral protease, in a patient who had not received antiviral therapy.", "doi": "10.1007/s00705-021-05029-7", "pmid": "33761008", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00705-021-05029-7"}], "notes": [], "created": "2021-03-25T14:00:14.895Z", "modified": "2021-03-25T14:00:14.918Z"}, {"entity": "publication", "iuid": "1d97075d697d4aafba9f1829a8f000c7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d97075d697d4aafba9f1829a8f000c7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d97075d697d4aafba9f1829a8f000c7"}}, "title": "Challenges and opportunities to end tuberculosis in the COVID-19 era.", "authors": [{"family": "Wingfield", "given": "Tom", "initials": "T"}, {"family": "Karmadwala", "given": "Fatima", "initials": "F"}, {"family": "MacPherson", "given": "Peter", "initials": "P"}, {"family": "Millington", "given": "Kerry A", "initials": "KA"}, {"family": "Walker", "given": "Naomi F", "initials": "NF"}, {"family": "Cuevas", "given": "Luis E", "initials": "LE"}, {"family": "Squire", "given": "S Bertel", "initials": "SB"}], "type": "journal article", "published": "2021-03-24", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "issn-l": "2213-2600", "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/S2213-2600(21)00161-2", "pmid": "33773121", "labels": {"Category: Health": null, "Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(21)00161-2"}], "notes": [], "created": "2021-03-29T09:29:47.710Z", "modified": "2022-02-17T09:34:00.457Z"}, {"entity": "publication", "iuid": "5b6e21b205cd469c8bf809697ef51789", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5b6e21b205cd469c8bf809697ef51789.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5b6e21b205cd469c8bf809697ef51789"}}, "title": "Mental Health, Greenness, and Nature Related Behaviors in the Adult Population of Stockholm County during COVID-19-Related Restrictions.", "authors": [{"family": "L\u00f5hmus", "given": "Mare", "initials": "M"}, {"family": "Stenfors", "given": "Cecilia U D", "initials": "CUD"}, {"family": "Lind", "given": "Tomas", "initials": "T"}, {"family": "Lauber", "given": "Andr\u00e9", "initials": "A"}, {"family": "Georgelis", "given": "Antonios", "initials": "A"}], "type": "journal article", "published": "2021-03-23", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "6", "pages": null}, "abstract": "International data suggest that exposure to nature is beneficial for mental health and well-being. The restrictions related to the COVID-19 pandemic have created a setting that allows us to investigate the importance of greenness exposure on mental health during a period of increased isolation and worry. Based on 2060 responses from an online survey in Stockholm County, Sweden, we investigated: (1) whether the COVID-19 pandemic changed peoples' lifestyle and nature-related habits, and (2) if peoples' mental health differed depending on their exposure to greenness. Neighborhood greenness levels were quantified by using the average normalized difference vegetation index (NDVI) within 50 m, 100 m, 300 m, and 500 m buffers surrounding the participant's place of residence. We found that the number of individuals that reported that they visited natural areas \"often\" was significantly higher during the pandemic than before the pandemic. Higher levels of greenness surrounding one's location of residence were in general associated with higher mental health/well-being and vitality scores, and less symptoms of depression, anxiety, and perceived and cognitive stress, after adjustments for demographic variables and walkability. In conclusion, the results from the present study provided support to the suggestion that contact with nature may be important for mental health in extreme circumstances.", "doi": "10.3390/ijerph18063303", "pmid": "33806787", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "ijerph18063303"}], "notes": [], "created": "2021-04-06T10:33:24.157Z", "modified": "2021-06-18T15:35:59.689Z"}, {"entity": "publication", "iuid": "19d49bc018224174b5c789908cb243f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19d49bc018224174b5c789908cb243f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19d49bc018224174b5c789908cb243f4"}}, "title": "Lifestyle Habits and Mental Health in Light of the Two COVID-19 Pandemic Waves in Sweden, 2020.", "authors": [{"family": "Blom", "given": "Victoria", "initials": "V"}, {"family": "L\u00f6nn", "given": "Amanda", "initials": "A"}, {"family": "Ekblom", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Kallings", "given": "Lena V", "initials": "LV"}, {"family": "V\u00e4is\u00e4nen", "given": "Daniel", "initials": "D"}, {"family": "Hemmingsson", "given": "Erik", "initials": "E"}, {"family": "Andersson", "given": "Gunnar", "initials": "G"}, {"family": "Wallin", "given": "Peter", "initials": "P"}, {"family": "Stenling", "given": "Andreas", "initials": "A"}, {"family": "Ekblom", "given": "\u00d6rjan", "initials": "\u00d6"}, {"family": "Lindwall", "given": "Magnus", "initials": "M"}, {"family": "Salier Eriksson", "given": "Jane", "initials": "J"}, {"family": "Holmlund", "given": "Tobias", "initials": "T"}, {"family": "Ekblom-Bak", "given": "Elin", "initials": "E"}], "type": "journal article", "published": "2021-03-23", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "6", "pages": null}, "abstract": "The COVID-19 pandemic has become a public health emergency of international concern, which may have affected lifestyle habits and mental health. Based on national health profile assessments, this study investigated perceived changes of lifestyle habits in response to the COVID-19 pandemic and associations between perceived lifestyle changes and mental health in Swedish working adults. Among 5599 individuals (50% women, 46.3 years), the majority reported no change (sitting 77%, daily physical activity 71%, exercise 69%, diet 87%, alcohol 90%, and smoking 97%) due to the pandemic. Changes were more pronounced during the first wave (April-June) compared to the second (October-December). Women, individuals <60 years, those with a university degree, white-collar workers, and those with unhealthy lifestyle habits at baseline had higher odds of changing lifestyle habits compared to their counterparts. Negative changes in lifestyle habits and more time in a mentally passive state sitting at home were associated with higher odds of mental ill-health (including health anxiety regarding one's own and relatives' health, generalized anxiety and depression symptoms, and concerns regarding employment and economy). The results emphasize the need to support healthy lifestyle habits to strengthen the resilience in vulnerable groups of individuals to future viral pandemics and prevent health inequalities in society.", "doi": "10.3390/ijerph18063313", "pmid": "33806951", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph18063313"}], "notes": [], "created": "2021-04-06T10:32:29.491Z", "modified": "2021-06-18T15:36:38.808Z"}, {"entity": "publication", "iuid": "47ddf7c0b1374994a86b31d2fb52b9db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47ddf7c0b1374994a86b31d2fb52b9db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47ddf7c0b1374994a86b31d2fb52b9db"}}, "title": "Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation.", "authors": [{"family": "Chioh", "given": "Florence Wj", "initials": "FW"}, {"family": "Fong", "given": "Siew-Wai", "initials": "S"}, {"family": "Young", "given": "Barnaby E", "initials": "BE"}, {"family": "Wu", "given": "Kan-Xing", "initials": "K"}, {"family": "Siau", "given": "Anthony", "initials": "A"}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Chan", "given": "Yi-Hao", "initials": "Y"}, {"family": "Carissimo", "given": "Guillaume", "initials": "G"}, {"family": "Teo", "given": "Louis Ly", "initials": "LL"}, {"family": "Gao", "given": "Fei", "initials": "F"}, {"family": "Tan", "given": "Ru San", "initials": "RS"}, {"family": "Zhong", "given": "Liang", "initials": "L"}, {"family": "Koh", "given": "Angela S", "initials": "AS"}, {"family": "Tan", "given": "Seow-Yen", "initials": "S"}, {"family": "Tambyah", "given": "Paul A", "initials": "PA"}, {"family": "Renia", "given": "Laurent", "initials": "L"}, {"family": "Ng", "given": "Lisa Fp", "initials": "LF"}, {"family": "Lye", "given": "David C", "initials": "DC"}, {"family": "Cheung", "given": "Christine", "initials": "C"}], "type": "journal article", "published": "2021-03-23", "journal": {"title": "Elife", "issn": "2050-084X", "issn-l": null, "volume": "10", "issue": null, "pages": null}, "abstract": "Numerous reports of vascular events after an initial recovery from COVID-19 form our impetus to investigate the impact of COVID-19 on vascular health of recovered patients. We found elevated levels of circulating endothelial cells (CECs), a biomarker of vascular injury, in COVID-19 convalescents compared to healthy controls. In particular, those with pre-existing conditions (e.g., hypertension, diabetes) had more pronounced endothelial activation hallmarks than non-COVID-19 patients with matched cardiovascular risk. Several proinflammatory and activated T lymphocyte-associated cytokines sustained from acute infection to recovery phase, which correlated positively with CEC measures, implicating cytokine-driven endothelial dysfunction. Notably, we found higher frequency of effector T cells in our COVID-19 convalescents compared to healthy controls. The activation markers detected on CECs mapped to counter receptors found primarily on cytotoxic CD8 + T cells, raising the possibility of cytotoxic effector cells targeting activated endothelial cells. Clinical trials in preventive therapy for post-COVID-19 vascular complications may be needed.", "doi": "10.7554/eLife.64909", "pmid": "33752798", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Category: Post-COVID": null}, "xrefs": [{"db": "pii", "key": "64909"}], "notes": [], "created": "2021-03-24T06:53:57.063Z", "modified": "2021-07-09T12:41:18.717Z"}, {"entity": "publication", "iuid": "fb10dff4709e4303ba629b04a889cdca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb10dff4709e4303ba629b04a889cdca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb10dff4709e4303ba629b04a889cdca"}}, "title": "Author Correction: COVID-19 vaccine guidance for patients with cancer participating in oncology clinical trials.", "authors": [{"family": "Desai", "given": "Aakash", "initials": "A"}, {"family": "Gainor", "given": "Justin F", "initials": "JF"}, {"family": "Hegde", "given": "Aparna", "initials": "A"}, {"family": "Schram", "given": "Alison M", "initials": "AM"}, {"family": "Curigliano", "given": "Giuseppe", "initials": "G"}, {"family": "Pal", "given": "Sumanta", "initials": "S"}, {"family": "Liu", "given": "Stephen V", "initials": "SV"}, {"family": "Halmos", "given": "Balazs", "initials": "B"}, {"family": "Groisberg", "given": "Roman", "initials": "R"}, {"family": "Grande", "given": "Enrique", "initials": "E"}, {"family": "Dragovich", "given": "Tomislav", "initials": "T"}, {"family": "Matrana", "given": "Marc", "initials": "M"}, {"family": "Agarwal", "given": "Neeraj", "initials": "N"}, {"family": "Chawla", "given": "Sant", "initials": "S"}, {"family": "Kato", "given": "Shumei", "initials": "S"}, {"family": "Morgan", "given": "Gilberto", "initials": "G"}, {"family": "Kasi", "given": "Pashtoon M", "initials": "PM"}, {"family": "Solomon", "given": "Benjamin", "initials": "B"}, {"family": "Loong", "given": "Herbert H", "initials": "HH"}, {"family": "Park", "given": "Haeseong", "initials": "H"}, {"family": "Choueiri", "given": "Toni K", "initials": "TK"}, {"family": "Subbiah", "given": "Ishwaria M", "initials": "IM"}, {"family": "Pemmaraju", "given": "Naveen", "initials": "N"}, {"family": "Subbiah", "given": "Vivek", "initials": "V"}, {"family": "COVID19 and Cancer Clinical Trials Working Group", "given": "", "initials": ""}], "type": "published erratum", "published": "2021-03-23", "journal": {"title": "Nat Rev Clin Oncol", "issn": "1759-4782", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1038/s41571-021-00503-2", "pmid": "33758378", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41571-021-00503-2"}], "notes": [], "created": "2021-03-25T13:59:04.682Z", "modified": "2021-03-25T13:59:21.437Z"}, {"entity": "publication", "iuid": "f701ebff8c074df0a2d724d4d0c577a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f701ebff8c074df0a2d724d4d0c577a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f701ebff8c074df0a2d724d4d0c577a6"}}, "title": "Virus-Induced Changes of the Respiratory Tract Environment Promote Secondary Infections With Streptococcus pneumoniae.", "authors": [{"family": "Sender", "given": "Vicky", "initials": "V"}, {"family": "Hentrich", "given": "Karina", "initials": "K"}, {"family": "Henriques-Normark", "given": "Birgitta", "initials": "B"}], "type": "journal article", "published": "2021-03-22", "journal": {"title": "Front Cell Infect Microbiol", "issn": "2235-2988", "volume": "11", "issue": null, "pages": "643326", "issn-l": null}, "abstract": "Secondary bacterial infections enhance the disease burden of influenza infections substantially. Streptococcus pneumoniae (the pneumococcus) plays a major role in the synergism between bacterial and viral pathogens, which is based on complex interactions between the pathogen and the host immune response. Here, we discuss mechanisms that drive the pathogenesis of a secondary pneumococcal infection after an influenza infection with a focus on how pneumococci senses and adapts to the influenza-modified environment. We briefly summarize what is known regarding secondary bacterial infection in relation to COVID-19 and highlight the need to improve our current strategies to prevent and treat viral bacterial coinfections.", "doi": "10.3389/fcimb.2021.643326", "pmid": "33828999", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8019817"}], "notes": [], "created": "2021-04-09T16:44:47.845Z", "modified": "2021-04-28T18:23:24.262Z"}, {"entity": "publication", "iuid": "8a1b420ce97d49dab7916be3f1fd7515", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a1b420ce97d49dab7916be3f1fd7515.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a1b420ce97d49dab7916be3f1fd7515"}}, "title": "Targeting CX3CR1 Suppresses the Fanconi Anemia DNA Repair Pathway and Synergizes with Platinum.", "authors": [{"family": "Lehto", "given": "Jemina", "initials": "J"}, {"family": "Huguet Ninou", "given": "Anna", "initials": "A"}, {"family": "Chioureas", "given": "Dimitrios", "initials": "D"}, {"family": "Jonkers", "given": "Jos", "initials": "J"}, {"family": "Gustafsson", "given": "Nina M S", "initials": "NMS"}], "type": "journal article", "published": "2021-03-22", "journal": {"title": "Cancers (Basel)", "issn": "2072-6694", "issn-l": null, "volume": "13", "issue": "6", "pages": null}, "abstract": "The C-X3-C motif chemokine receptor 1 (CX3CR1, fractalkine receptor) is associated with neoplastic transformation, inflammation, neurodegenerative diseases and aging, and the small molecule inhibitor KAND567 targeting CX3CR1 (CX3CR1i) is evaluated in clinical trials for acute systemic inflammation upon SARS-CoV-2 infections. Here we identify a hitherto unknown role of CX3CR1 in Fanconi anemia (FA) pathway mediated repair of DNA interstrand crosslinks (ICLs) in replicating cells. FA pathway activation triggers CX3CR1 nuclear localization which facilitates assembly of the key FA protein FANCD2 into foci. Interfering with CX3CR1 function upon ICL-induction results in inability of replicating cells to progress from S phase, replication fork stalling and impaired chromatin recruitment of key FA pathway factors. Consistent with defective FA repair, CX3CR1i results in increased levels of residual cisplatin-DNA adducts and decreased cell survival. Importantly, CX3CR1i synergizes with platinum agents in a nonreversible manner in proliferation assays including platinum resistant models. Taken together, our results reveal an unanticipated interplay between CX3CR1 and the FA pathway and show for the first time that a clinical-phase small molecule inhibitor targeting CX3CR1 might show benefit in improving responses to DNA crosslinking chemotherapeutics.", "doi": "10.3390/cancers13061442", "pmid": "33810010", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "cancers13061442"}], "notes": [], "created": "2021-04-06T10:23:48.973Z", "modified": "2021-04-07T13:23:58.431Z"}, {"entity": "publication", "iuid": "4118c1f7f7d24411a4a599164ed5f37e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4118c1f7f7d24411a4a599164ed5f37e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4118c1f7f7d24411a4a599164ed5f37e"}}, "title": "Risk of severe allergic reactions to COVID-19 vaccines among patients with allergic skin diseases - practical recommendations. A position statement of ETFAD with external experts.", "authors": [{"family": "Ring", "given": "J", "initials": "J"}, {"family": "Worm", "given": "M", "initials": "M"}, {"family": "Wollenberg", "given": "A", "initials": "A"}, {"family": "Thyssen", "given": "J P", "initials": "JP"}, {"family": "Jakob", "given": "T", "initials": "T"}, {"family": "Klimek", "given": "L", "initials": "L"}, {"family": "Bangert", "given": "C", "initials": "C"}, {"family": "Barbarot", "given": "S", "initials": "S"}, {"family": "Bieber", "given": "T", "initials": "T"}, {"family": "de Bruin-Weller", "given": "M S", "initials": "MS"}, {"family": "Chernyshov", "given": "P V", "initials": "PV"}, {"family": "Christen-Zaech", "given": "S", "initials": "S"}, {"family": "Cork", "given": "M", "initials": "M"}, {"family": "Darsow", "given": "U", "initials": "U"}, {"family": "Flohr", "given": "C", "initials": "C"}, {"family": "F\u00f6lster-Holst", "given": "R", "initials": "R"}, {"family": "Gelmetti", "given": "C", "initials": "C"}, {"family": "Gieler", "given": "U", "initials": "U"}, {"family": "Gutermuth", "given": "J", "initials": "J"}, {"family": "Heratizadeh", "given": "A", "initials": "A"}, {"family": "Hijnen", "given": "D J", "initials": "DJ"}, {"family": "von Kobyletzki", "given": "L B", "initials": "LB"}, {"family": "Kunz", "given": "B", "initials": "B"}, {"family": "Paul", "given": "C", "initials": "C"}, {"family": "Seneschal", "given": "Julien", "initials": "J"}, {"family": "Simon", "given": "D", "initials": "D"}, {"family": "Spuls", "given": "P I", "initials": "PI"}, {"family": "Stalder", "given": "J F", "initials": "JF"}, {"family": "Svensson", "given": "A", "initials": "A"}, {"family": "Szalai", "given": "Z", "initials": "Z"}, {"family": "Taieb", "given": "A", "initials": "A"}, {"family": "Torrelo", "given": "A", "initials": "A"}, {"family": "Trzeciak", "given": "M", "initials": "M"}, {"family": "Werfel", "given": "T", "initials": "T"}, {"family": "Weidinger", "given": "S", "initials": "S"}, {"family": "Deleuran", "given": "M", "initials": "M"}], "type": "letter", "published": "2021-03-22", "journal": {"title": "J Eur Acad Dermatol Venereol", "issn": "1468-3083", "volume": null, "issue": null, "issn-l": null}, "abstract": "Since the introduction of active vaccination against SARS-CoV-2 infection, there has been a debate about the risk of developing severe allergic or anaphylactic reactions among individuals with a history of allergy. Indeed, rare cases of severe allergic reactions have been reported in the United Kingdom and North America. By february 2021 a rate of 4,5 severe allergic reactions occurred among 1 million patients vaccinated with the mRNA-based COVID-19 vaccines, which is higher than the generally expected rate of severe allergic reactions to vaccinations of around 1 in 1 million.", "doi": "10.1111/jdv.17237", "pmid": "33752263", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-03-24T06:53:28.426Z", "modified": "2021-03-24T06:53:28.438Z"}, {"entity": "publication", "iuid": "46adafc19dc74c4d9319e7815d83a39b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46adafc19dc74c4d9319e7815d83a39b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46adafc19dc74c4d9319e7815d83a39b"}}, "title": "Measurement Invariance of the Drivers of COVID-19 Vaccination Acceptance Scale: Comparison between Taiwanese and Mainland Chinese-Speaking Populations.", "authors": [{"family": "Yeh", "given": "Ya-Chin", "initials": "Y"}, {"family": "Chen", "given": "I-Hua", "initials": "I"}, {"family": "Ahorsu", "given": "Daniel K", "initials": "DK"}, {"family": "Ko", "given": "Nai-Ying", "initials": "N"}, {"family": "Chen", "given": "Kuan-Lin", "initials": "K"}, {"family": "Li", "given": "Ping-Chia", "initials": "P"}, {"family": "Yen", "given": "Cheng-Fang", "initials": "C"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-03-22", "journal": {"title": "Vaccines", "issn": "2076-393X", "issn-l": null, "volume": "9", "issue": "3", "pages": null}, "abstract": "The impacts of novel coronavirus disease-2019 (COVID-19) on human life continue to be serious. To control the spread of COVID-19, the production of effective vaccines is likely to be one of the best solutions. However, vaccination hesitancy may decrease individuals' willingness to get vaccinated. The Drivers of COVID-19 Vaccination Acceptance Scale (DrVac-COVID19S) was recently developed to help healthcare professionals and researchers better understand vaccination acceptance. The present study examined whether DrVac-COVID19S is measurement invariant across different subgroups (Taiwanese vs. mainland Chinese university students; males vs. females; and health-related program majors vs. non-health-related program majors). Taiwanese ( n = 761; mean age = 25.51 years; standard deviation (SD) = 6.42; 63.5% females) and mainland Chinese university students (n = 3145; mean age = 20.72 years; SD = 2.06; 50.2% females) were recruited using an online survey between 5 January and 21 February 2021. Factor structure and measurement invariance of the two DrVac-COVID19S scales (nine-item and 12-item) were tested using confirmatory factor analysis (CFA). The findings indicated that the DrVac-COVID19S had a four-factor structure and was measurement invariant across the subgroups. The DrVac-COVID19S's four-factor structure was supported by the CFA results is a practical and valid instrument to quickly capture university students' willingness to get COVID-19 vaccination. Moreover, the DrVac-COVID19S can be used to compare university students' underlying reasons to get COVID-19 vaccination among different subgroups.", "doi": "10.3390/vaccines9030297", "pmid": "33810036", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "vaccines9030297"}], "notes": [], "created": "2021-04-06T10:23:00.038Z", "modified": "2021-06-18T15:34:51.780Z"}, {"entity": "publication", "iuid": "8e9da1eddbce4edda487f0a7a41c34f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e9da1eddbce4edda487f0a7a41c34f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e9da1eddbce4edda487f0a7a41c34f7"}}, "title": "Antibody kinetics and clinical course of COVID-19 a prospective observational study.", "authors": [{"family": "Bl\u00e4ckberg", "given": "Anna", "initials": "A"}, {"family": "Fernstr\u00f6m", "given": "Nils", "initials": "N"}, {"family": "Sarbrant", "given": "Emma", "initials": "E"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}, {"family": "Sunnerhagen", "given": "Torgny", "initials": "T"}], "type": "journal article", "published": "2021-03-22", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "3", "pages": "e0248918", "issn-l": "1932-6203"}, "abstract": "Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19.\n\nA prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over time in patients with COVID-19. Possible associations between antibody titers and outcome were analyzed.\n\nForty patients with COVID-19, hospitalized at Sk\u00e5ne University hospital, Sweden, between April and June 2020 were included. IgG antibody responses were detected for all patients with the highest levels four weeks after COVID-19 diagnosis. Levels of IgA were generally higher at diagnosis and decreased towards baseline 4 weeks after confirmed COVID-19. Patients with severe COVID-19 had higher levels of antibodies directed against SARS-CoV-2 spike protein compared with patients with mild disease.\n\nIgG and IgA antibodies towards the spike protein follow different kinetics during COVID-19 and patients with severe disease develop higher antibody levels.", "doi": "10.1371/journal.pone.0248918", "pmid": "33750984", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-21-01958"}], "notes": [], "created": "2021-03-24T06:57:06.356Z", "modified": "2021-03-24T06:57:06.366Z"}, {"entity": "publication", "iuid": "901e54458cd04c57bd0479eaba9f68ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/901e54458cd04c57bd0479eaba9f68ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/901e54458cd04c57bd0479eaba9f68ca"}}, "title": "Acute kidney injury and mortality risk in older adults with COVID-19.", "authors": [{"family": "Xu", "given": "Hong", "initials": "H"}, {"family": "Garcia-Ptacek", "given": "Sara", "initials": "S"}, {"family": "Annetorp", "given": "Martin", "initials": "M"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Cederholm", "given": "Tommy", "initials": "T"}, {"family": "Johnson", "given": "Peter", "initials": "P"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Metzner", "given": "Carina", "initials": "C"}, {"family": "Religa", "given": "Dorota", "initials": "D"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-03-22", "journal": {"title": "J Nephrol", "issn": "1724-6059", "volume": null, "issue": null, "issn-l": null}, "abstract": "Research regarding COVID-19 and acute kidney injury (AKI) in older adults is scarce. We evaluated risk factors and outcomes of AKI in hospitalized older adults with and without COVID-19.\n\nObservational study of patients admitted to two geriatric clinics in Stockholm from March 1st to June 15th, 2020. The difference in incidence, risk factors and adverse outcomes for AKI between patients with or without COVID-19 were examined. Odds ratios (OR) for the risk of AKI and in-hospital death were obtained from logistic regression.\n\nThree hundred-sixteen older patients were hospitalized for COVID-19 and 876 patients for non-COVID-19 diagnoses. AKI occurred in 92 (29%) patients with COVID-19 vs. 159 (18%) without COVID-19. The odds for developing AKI were higher in patients with COVID-19 (adjusted OR, 1.70; 95% confidence interval [CI] 1.04-2.76), low baseline kidney function as depicted by estimated glomerular filtration rate (eGFR) [4.19 (2.48-7.05), for eGFR 30 to < 60 mL/min, and 20.3 (9.95-41.3) for eGFR < 30 mL/min], and higher C reactive protein (CRP) (OR 1.81 (1.11-2.95) in patients with initial CRP > 10 mg/L). Compared to patients without COVID-19 and without AKI, the risk of in-hospital death was highest in patients with COVID-19 and AKI [OR 80.3, 95% CI (27.3-235.6)], followed by COVID-19 without AKI [16.3 (6.28-42.4)], and by patients without COVID-19 and with AKI [10.2 (3.66-28.2)].\n\nGeriatric patients hospitalized with COVID-19 had a higher incidence of AKI compared to patients hospitalized for other diagnoses. COVID-19 and reduced baseline kidney function were risk factors for developing AKI. AKI and COVID-19 were associated with in-hospital death.", "doi": "10.1007/s40620-021-01022-0", "pmid": "33751497", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40620-021-01022-0"}], "notes": [], "created": "2021-03-24T06:55:25.358Z", "modified": "2021-03-24T06:56:15.523Z"}, {"entity": "publication", "iuid": "c737c114c2434b338293ab491edc103d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c737c114c2434b338293ab491edc103d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c737c114c2434b338293ab491edc103d"}}, "title": "Identification of Potential SARS-CoV-2 Main Protease and Spike Protein Inhibitors from the Genus Aloe: An In Silico Study for Drug Development.", "authors": [{"family": "Abouelela", "given": "Mohamed E", "initials": "ME"}, {"family": "Assaf", "given": "Hamdy K", "initials": "HK"}, {"family": "Abdelhamid", "given": "Reda A", "initials": "RA"}, {"family": "Elkhyat", "given": "Ehab S", "initials": "ES"}, {"family": "Sayed", "given": "Ahmed M", "initials": "AM"}, {"family": "Oszako", "given": "Tomasz", "initials": "T"}, {"family": "Belbahri", "given": "Lassaad", "initials": "L"}, {"family": "El Zowalaty", "given": "Ahmed E", "initials": "AE"}, {"family": "Abdelkader", "given": "Mohamed Salaheldin A", "initials": "MSA"}], "type": "journal article", "published": "2021-03-21", "journal": {"title": "Molecules", "issn": "1420-3049", "volume": "26", "issue": "6", "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus (SARS-CoV-2) disease is a global rapidly spreading virus showing very high rates of complications and mortality. Till now, there is no effective specific treatment for the disease. Aloe is a rich source of isolated phytoconstituents that have an enormous range of biological activities. Since there are no available experimental techniques to examine these compounds for antiviral activity against SARS-CoV-2, we employed an in silico approach involving molecular docking, dynamics simulation, and binding free energy calculation using SARS-CoV-2 essential proteins as main protease and spike protein to identify lead compounds from Aloe that may help in novel drug discovery. Results retrieved from docking and molecular dynamics simulation suggested a number of promising inhibitors from Aloe. Root mean square deviation (RMSD) and root mean square fluctuation (RMSF) calculations indicated that compounds 132, 134, and 159 were the best scoring compounds against main protease, while compounds 115, 120, and 131 were the best scoring ones against spike glycoprotein. Compounds 120 and 131 were able to achieve significant stability and binding free energies during molecular dynamics simulation. In addition, the highest scoring compounds were investigated for their pharmacokinetic properties and drug-likeness. The Aloe compounds are promising active phytoconstituents for drug development for SARS-CoV-2.", "doi": "10.3390/molecules26061767", "pmid": "33801151", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "molecules26061767"}], "notes": [], "created": "2021-04-06T10:39:45.088Z", "modified": "2021-04-06T10:39:45.099Z"}, {"entity": "publication", "iuid": "c23fb84e01e842a283193fca3cd80504", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c23fb84e01e842a283193fca3cd80504.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c23fb84e01e842a283193fca3cd80504"}}, "title": "Fear of COVID-19 Scale (FCV-19S) across countries: Measurement invariance issues.", "authors": [{"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Hou", "given": "Wen-Li", "initials": "W"}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA"}, {"family": "Aparecido da Silva", "given": "Jos\u00e9", "initials": "J"}, {"family": "Broche-P\u00e9rez", "given": "Yunier", "initials": "Y"}, {"family": "Ullah", "given": "Irfan", "initials": "I"}, {"family": "Masuyama", "given": "Akihiro", "initials": "A"}, {"family": "Wakashima", "given": "Koubun", "initials": "K"}, {"family": "Mailliez", "given": "M\u00e9lody", "initials": "M"}, {"family": "Carre", "given": "Arnaud", "initials": "A"}, {"family": "Chen", "given": "Yu-Pin", "initials": "Y"}, {"family": "Chang", "given": "Kun-Chia", "initials": "K"}, {"family": "Kuo", "given": "Yi-Jie", "initials": "Y"}, {"family": "Soraci", "given": "Paolo", "initials": "P"}, {"family": "Scarf", "given": "Damian", "initials": "D"}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2021-03-21", "journal": {"title": "Nurs Open", "issn": "2054-1058", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The threats of novel coronavirus disease 2019 (COVID-19) have caused fears worldwide. The Fear of COVID-19 Scale (FCV-19S) was recently developed to assess the fear of COVID-19. Although many studies found that the FCV-19S is psychometrically sound, it is unclear whether the FCV-19S is invariant across countries. The present study aimed to examine the measurement invariance of the FCV-19S across eleven countries.\r\n\r\nCross-sectional study.\r\n\r\nUsing data collected from prior research on Bangladesh (N = 8,550), United Kingdom (N = 344), Brazil (N = 1,843), Taiwan (N = 539), Italy (N = 249), New Zealand (N = 317), Iran (N = 717), Cuba (N = 772), Pakistan (N = 937), Japan (N = 1,079) and France (N = 316), comprising a total 15,663 participants, the present study used the multigroup confirmatory factor analysis (CFA) and Rasch differential item functioning (DIF) to examine the measurement invariance of the FCV-19S across country, gender and age (children aged below 18 years, young to middle-aged adults aged between 18 and 60 years, and older people aged above 60 years).\r\n\r\nThe unidimensional structure of the FCV-19S was confirmed. Multigroup CFA showed that FCV-19S was partially invariant across country and fully invariant across gender and age. DIF findings were consistent with the findings from multigroup CFA. Many DIF items were displayed for country, few DIF items were displayed for age, and no DIF items were displayed for gender.\r\n\r\nBased on the results of the present study, the FCV-19S is a good psychometric instrument to assess fear of COVID-19 during the pandemic period. Moreover, the use of FCV-19S is supported in at least ten countries with satisfactory psychometric properties.", "doi": "10.1002/nop2.855", "pmid": "33745219", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-24T07:00:44.363Z", "modified": "2021-06-18T15:29:27.945Z"}, {"entity": "publication", "iuid": "a2a1735641c64bba9ec00b061e463c38", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a2a1735641c64bba9ec00b061e463c38.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a2a1735641c64bba9ec00b061e463c38"}}, "title": "Anti-SARS-CoV2 antibody responses in serum and cerebrospinal fluid of COVID-19 patients with neurological symptoms", "authors": [{"family": "Cunningham", "given": "Janet L", "initials": "JL"}, {"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B"}, {"family": "Castro Dopico", "given": "Xaquin", "initials": "X"}, {"family": "Kolstad", "given": "Linda", "initials": "L"}, {"family": "Albinsson", "given": "Bo", "initials": "B"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "N\u00e4\u00e4s", "given": "Anja", "initials": "A"}, {"family": "Klang", "given": "Andrea", "initials": "A"}, {"family": "Westman", "given": "Gabriel", "initials": "G"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e314740b02c344d2b336a9410e28041e.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Rostami", "given": "Elham", "initials": "E", "orcid": "0000-0003-1218-6247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c95efe7a4cc4fcfa73fac8b49641ca1.json"}}], "type": "journal-article", "published": "2021-03-21", "journal": {"title": "The Journal of Infectious Diseases", "issn": "0022-1899", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Antibody responses to SARS-CoV-2 in serum and CSF from 16 COVID-19 patients with neurological symptoms were assessed using two independent methods. IgG specific for the virus spike protein was found in 81% of cases in serum and in 56% in CSF. SARS-CoV-2 IgG in CSF was observed in two cases with negative serology. Levels of IgG in both serum and CSF were associated with disease severity (p<0.05). All patients with elevated markers of CNS damage in CSF also had CSF antibodies (p=0.002), and CSF antibodies had the highest predictive value for neuronal damage markers of all tested clinical variables.", "doi": "10.1093/infdis/jiab153", "pmid": "33744954", "labels": {"Category: Health": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Funder: VR": null, "Category: Proteins": null, "Funder: H2020": null, "Research Area: High-throughput and high-content serology": null}, "xrefs": [{"db": "pii", "key": "6179304"}, {"db": "pmc", "key": "PMC8083780"}], "notes": [], "created": "2021-03-22T10:01:02.020Z", "modified": "2021-12-12T18:07:55.909Z"}, {"entity": "publication", "iuid": "038bbdb7ac4b4dd283edbe6d0049a203", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/038bbdb7ac4b4dd283edbe6d0049a203.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/038bbdb7ac4b4dd283edbe6d0049a203"}}, "title": "An Agent-Based Model of Local Pandemic Spread: Analysis of SARS-CoV-2.", "authors": [{"family": "Staffini", "given": "Alessio", "initials": "A"}, {"family": "Svensson", "given": "Akiko Kishi", "initials": "AK"}, {"family": "Chung", "given": "Ung-Il", "initials": "UI"}, {"family": "Svensson", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2021-03-21", "journal": {"title": "JMIR Med Inform", "issn": "2291-9694", "volume": null, "issue": null, "issn-l": null}, "abstract": "The spread of the SARS-CoV-2 virus originating in Wuhan, China, was classified as a pandemic by the World Health Organization (WHO) on March 11, 2020. The governments of affected countries have implemented various measures to limit the spread of the virus. The starting point of this paper is the different government approaches, in terms of promulgating new legislative regulations to limit the virus diffusion and to contain negative effects on the populations.\n\nThe objective of this paper is to study how the spread of the SARS-CoV-2 virus is linked to the government policies, and to analyse how different policies have produced different results on public health.\n\nConsidering the official data provided by 4 countries (Italy, Germany, Sweden and Brazil) and from the measures implemented by their respective governments, we built an Agent-Based Model (ABM) to study the effects that these measures will have over time on different variables such as the total number of COVID-19 cases, intensive care unit (ICU) bed occupancy rates, and recovery and case fatality rates. The model we implemented provides for the possibility of modifying some starting variables, and it was thus possible to study the effects that some policies (such as keeping the national borders closed or the increase in ICU beds) would have had on the spread of the infection.\n\nThe 4 considered countries have adopted different containment measures for SARS-CoV-2, and the forecasts provided by the model for the considered variables have given different results. Italy and Germany seem to be able to limit the spread of the infection and any eventual \"second wave\", while Sweden and Brazil do not seem to have the situation under control. This situation is reflected also in the forecasts of pressure on the National Health Services, which see Sweden and Brazil with a high occupancy rate of ICU beds also in the coming months, with a consequent high number of deaths.\n\nIn line with what we expected, the obtained results show that the countries that have taken very restrictive measures in terms of limiting the mobility of the population have managed, more successfully than others, to contain the spread of SARS-CoV-2. Moreover, the model demonstrates that herd immunity cannot be reached even in countries which have relied on a strategy without strict containment measures.\n\nNot Applicable.", "doi": "10.2196/24192", "pmid": "33750735", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-03-24T06:57:45.986Z", "modified": "2021-03-24T06:57:57.046Z"}, {"entity": "publication", "iuid": "2ccb5a5c59b647dbb970f0e5430d547c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ccb5a5c59b647dbb970f0e5430d547c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ccb5a5c59b647dbb970f0e5430d547c"}}, "title": "A bispecific monomeric nanobody induces SARS-COV-2 spike trimer dimers", "authors": [{"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Das", "given": "Hrishikesh", "initials": "H"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Vidakovics", "given": "Laura Perez", "initials": "LP"}, {"family": "Urgard", "given": "Egon", "initials": "E"}, {"family": "Moliner-Morro", "given": "Ainhoa", "initials": "A"}, {"family": "Karl", "given": "Vivien", "initials": "V"}, {"family": "Pankow", "given": "Alec", "initials": "A"}, {"family": "Kim", "given": "Changil", "initials": "C"}, {"family": "Smith", "given": "Natalie L", "initials": "NL"}, {"family": "Pedersen", "given": "Gabriel K", "initials": "GK"}, {"family": "Coquet", "given": "Jonathan M", "initials": "JM"}, {"family": "H\u00e4llberg", "given": "B Martin", "initials": "BM"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}], "type": "posted-content", "published": "2021-03-21", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.20.436243", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "Materials will be made available when the article is published in a journal", "description": null}], "notes": [], "created": "2021-03-24T06:32:39.788Z", "modified": "2021-04-15T18:54:39.609Z"}, {"entity": "publication", "iuid": "2e9b4e77e3da40ebbfa0ec005dcac230", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e9b4e77e3da40ebbfa0ec005dcac230.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e9b4e77e3da40ebbfa0ec005dcac230"}}, "title": "COVID-19 collateral damage: psychological distress and behavioral changes among older adults during the first outbreak in Stockholm, Sweden", "authors": [{"family": "Beridze", "given": "Giorgi", "initials": "G"}, {"family": "Triolo", "given": "Federico", "initials": "F"}, {"family": "Grande", "given": "Giulia", "initials": "G"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A"}], "type": "posted-content", "published": "2021-03-20", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.16.21253750", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null, "Funder: VR": null}, "xrefs": [{"db": "URL", "key": "http://www.snac-k.se/", "description": "Data available through the the Swedish National study on Aging and Care in Kungsholmen"}], "notes": [], "created": "2021-03-25T14:03:00.839Z", "modified": "2021-04-26T18:07:59.411Z"}, {"entity": "publication", "iuid": "cc0d3b576b9545758a36e109cd7cb47d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc0d3b576b9545758a36e109cd7cb47d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc0d3b576b9545758a36e109cd7cb47d"}}, "title": "Alternative splicing of OAS1 alters the risk for severe COVID-19", "authors": [{"family": "Huffman", "given": "Jennifer", "initials": "J"}, {"family": "Butler-Laporte", "given": "Guillaume", "initials": "G"}, {"family": "Khan", "given": "Atlas", "initials": "A"}, {"family": "Drivas", "given": "Theodore G", "initials": "TG"}, {"family": "Peloso", "given": "Gina M", "initials": "GM"}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T"}, {"family": "Verma", "given": "Anurag", "initials": "A"}, {"family": "Kiryluk", "given": "Krzysztof", "initials": "K"}, {"family": "Richards", "given": "J Brent", "initials": "JB"}, {"family": "Zeberg", "given": "Hugo", "initials": "H"}], "type": "posted-content", "published": "2021-03-20", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.20.21254005", "pmid": null, "labels": {"Category: Genomics & transcriptomics": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-03-25T14:09:33.955Z", "modified": "2021-03-29T10:15:48.708Z"}, {"entity": "publication", "iuid": "e053d3a1434949cba8dbc6919d1f7f5a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e053d3a1434949cba8dbc6919d1f7f5a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e053d3a1434949cba8dbc6919d1f7f5a"}}, "title": "Umbilical cord blood-derived microglia-like cells to model COVID-19 exposure.", "authors": [{"family": "Sheridan", "given": "Steven D", "initials": "SD"}, {"family": "Thanos", "given": "Jessica M", "initials": "JM", "orcid": "0000-0001-7984-5361", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc172e4bc4f14c81b166a2d59a696dc8.json"}}, {"family": "De Guzman", "given": "Rose M", "initials": "RM", "orcid": "0000-0002-4563-8628", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/288794dac78b4cb4b0d22b66d11d96d0.json"}}, {"family": "McCrea", "given": "Liam T", "initials": "LT", "orcid": "0000-0002-6738-4681", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3433cc21b02f4c3da64a9b0d78b7af64.json"}}, {"family": "Horng", "given": "Joy E", "initials": "JE"}, {"family": "Fu", "given": "Ting", "initials": "T"}, {"family": "Sellgren", "given": "Carl M", "initials": "CM"}, {"family": "Perlis", "given": "Roy H", "initials": "RH", "orcid": "0000-0002-5862-6757", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f1335ae4cb1c48b3987d8e3188ca7a33.json"}}, {"family": "Edlow", "given": "Andrea G", "initials": "AG"}], "type": "journal article", "published": "2021-03-19", "journal": {"title": "Transl Psychiatry", "issn": "2158-3188", "volume": "11", "issue": "1", "pages": "179", "issn-l": null}, "abstract": "Microglia, the resident brain immune cells, play a critical role in normal brain development, and are impacted by the intrauterine environment, including maternal immune activation and inflammatory exposures. The COVID-19 pandemic presents a potential developmental immune challenge to the fetal brain, in the setting of maternal SARS-CoV-2 infection with its attendant potential for cytokine production and, in severe cases, cytokine storming. There is currently no biomarker or model for in utero microglial priming and function that might aid in identifying the neonates and children most vulnerable to neurodevelopmental morbidity, as microglia remain inaccessible in fetal life and after birth. This study aimed to generate patient-derived microglial-like cell models unique to each neonate from reprogrammed umbilical cord blood mononuclear cells, adapting and extending a novel methodology previously validated for adult peripheral blood mononuclear cells. We demonstrate that umbilical cord blood mononuclear cells can be used to create microglial-like cell models morphologically and functionally similar to microglia observed in vivo. We illustrate the application of this approach by generating microglia from cells exposed and unexposed to maternal SARS-CoV-2 infection. Our ability to create personalized neonatal models of fetal brain immune programming enables non-invasive insights into fetal brain development and potential childhood neurodevelopmental vulnerabilities for a range of maternal exposures, including COVID-19.", "doi": "10.1038/s41398-021-01287-w", "pmid": "33741894", "labels": {"Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41398-021-01287-w"}, {"db": "pmc", "key": "PMC7976669"}], "notes": [], "created": "2021-03-22T10:28:54.662Z", "modified": "2021-11-18T13:50:03.787Z"}, {"entity": "publication", "iuid": "443177b2f06947178dc99c1684f325fb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/443177b2f06947178dc99c1684f325fb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/443177b2f06947178dc99c1684f325fb"}}, "title": "Exploring associations between children's obesogenic behaviours and local environment using big data.", "authors": [{"family": "Filos", "given": "Dimitris", "initials": "D"}, {"family": "Lekka", "given": "Irini", "initials": "I"}, {"family": "Kilintzis", "given": "Vasileios", "initials": "V"}, {"family": "Stefanopoulos", "given": "Leandros", "initials": "L"}, {"family": "Karavidopoulou", "given": "Youla", "initials": "Y"}, {"family": "Maramis", "given": "Christos", "initials": "C"}, {"family": "Diou", "given": "Christos", "initials": "C"}, {"family": "Sarafis", "given": "Ioannis", "initials": "I"}, {"family": "Papapanagiotou", "given": "Vasileios", "initials": "V"}, {"family": "Alagialoglou", "given": "Leonidas", "initials": "L"}, {"family": "Ioakeimidis", "given": "Ioannis", "initials": "I"}, {"family": "Hassapidou", "given": "Maria", "initials": "M"}, {"family": "Charmandari", "given": "Evangelia", "initials": "E"}, {"family": "Heimeier", "given": "Rachel", "initials": "R"}, {"family": "O'Donnell", "given": "Shane", "initials": "S"}, {"family": "Doyle", "given": "Gerardine", "initials": "G"}, {"family": "Delopoulos", "given": "Anastasios", "initials": "A"}, {"family": "Maglaveras", "given": "Nicos", "initials": "N"}], "type": "journal article", "published": "2021-03-19", "journal": {"title": "JMIR Mhealth Uhealth", "issn": "2291-5222", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Obesity is a major public health problem globally and in Europe, while the prevalence of childhood obesity is also soaring. Several parameters of the living environment are contributing to this increase, such as the density of fast-food retailers, and thus, preventive health policies against childhood obesity must focus on the environment to which children are exposed. Currently, there are no systems to objectively measure the effect of living environment parameters on obesogenic behaviours and obesity. The H2020 project \"BigO: Big Data Against Childhood Obesity\" (http://bigoprogram.eu) aims to tackle childhood obesity by creating new sources of evidence based on big data.\r\n\r\nThis paper introduces the Obesity Prevention dashboard (OPdashboard), implemented in the context of BigO, which offers an interactive data exploration of objective obesity related behaviours and local environment based on the data recorded using the BigO mHealth app.\r\n\r\nOPdashboard allows for (i) the real time monitoring of children's obesogenic behaviours in a city area, (ii) the extraction of associations between them and the local environment and, (iii) the evaluation of an intervention in time. More than 3700 children, from 33 schools and 2 clinics, in 5 European cities have been monitored using a custom-made mobile application for the extraction of behavioural patterns through the capturing of accelerometer and geolocation data, while online databases were assessed in order to have a description of the environment.\r\n\r\nThe preliminary association outcomes in two European cities, namely Thessaloniki in Greece and Stockholm in Sweden, indicate a correlation between children's eating and physical activity behaviours and the availability of food related places or sport facilities close to schools. In addition, OPdashboard was used to assess the modification of children's physical activity as the result of the health policies applied for the deceleration of the COVID-19 outbreak. The preliminary outcomes of the analysis revealed that in urban areas the decrease on physical activity was statistically significant, while in the suburbs a slight increase was observed. Those findings suggest the importance of the availability of open spaces on children's behavioural change. The above analyses act as initial investigations using the OPdashboard. Additional factors must be incorporated in order to optimize its use and have a clearer understanding of the results.\r\n\r\nThe paper describes in detail the OPdashboard which is exposed as a web interface (http://bigo.med.auth.gr:3838/). Its functionality was evaluated during a focus group with experts on public health, where its potential on the better understanding of the interplay between children's obesogenic behaviours and the environment was underlined.", "doi": "10.2196/26290", "pmid": "34048353", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-06-04T11:40:32.420Z", "modified": "2022-11-23T09:01:40.333Z"}, {"entity": "publication", "iuid": "9ddc9e800b23454e99345e581344e71c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ddc9e800b23454e99345e581344e71c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ddc9e800b23454e99345e581344e71c"}}, "title": "A privacy and security analysis of early-deployed COVID-19 contact tracing Android apps.", "authors": [{"family": "Hatamian", "given": "Majid", "initials": "M"}, {"family": "Wairimu", "given": "Samuel", "initials": "S"}, {"family": "Momen", "given": "Nurul", "initials": "N"}, {"family": "Fritsch", "given": "Lothar", "initials": "L"}], "type": "journal article", "published": "2021-03-19", "journal": {"title": "Empir Softw Eng", "issn": "1573-7616", "volume": "26", "issue": "3", "pages": "36", "issn-l": null}, "abstract": "As this article is being drafted, the SARS-CoV-2/COVID-19 pandemic is causing harm and disruption across the world. Many countries aimed at supporting their contact tracers with the use of digital contact tracing apps in order to manage and control the spread of the virus. Their idea is the automatic registration of meetings between smartphone owners for the quicker processing of infection chains. To date, there are many contact tracing apps that have already been launched and used in 2020. There has been a lot of speculations about the privacy and security aspects of these apps and their potential violation of data protection principles. Therefore, the developers of these apps are constantly criticized because of undermining users' privacy, neglecting essential privacy and security requirements, and developing apps under time pressure without considering privacy- and security-by-design. In this study, we analyze the privacy and security performance of 28 contact tracing apps available on Android platform from various perspectives, including their code's privileges, promises made in their privacy policies, and static and dynamic performances. Our methodology is based on the collection of various types of data concerning these 28 apps, namely permission requests, privacy policy texts, run-time resource accesses, and existing security vulnerabilities. Based on the analysis of these data, we quantify and assess the impact of these apps on users' privacy. We aimed at providing a quick and systematic inspection of the earliest contact tracing apps that have been deployed on multiple continents. Our findings have revealed that the developers of these apps need to take more cautionary steps to ensure code quality and to address security and privacy vulnerabilities. They should more consciously follow legal requirements with respect to apps' permission declarations, privacy principles, and privacy policy contents.", "doi": "10.1007/s10664-020-09934-4", "pmid": "33776548", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "9934"}, {"db": "pmc", "key": "PMC7978168"}], "notes": [], "created": "2021-03-30T12:15:34.168Z", "modified": "2021-03-30T12:15:34.179Z"}, {"entity": "publication", "iuid": "a9f78ac5ac6a4f04858a5282781170b8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a9f78ac5ac6a4f04858a5282781170b8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a9f78ac5ac6a4f04858a5282781170b8"}}, "title": "Proteomic blood profiling in mild, severe and critical COVID-19 patients.", "authors": [{"family": "Patel", "given": "Hamel", "initials": "H", "orcid": "0000-0001-7951-6728", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21f5082b1f284a9b901e66759825d8c6.json"}}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0002-3579-8804", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f0ae25211e354556a737b1a23c53c6e1.json"}}, {"family": "Dobson", "given": "Richard J B", "initials": "RJB", "orcid": "0000-0003-4224-9245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1e3de8d16fca4e7f86f4b1245047e9d0.json"}}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Gisslen", "given": "Magnus", "initials": "M"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e314740b02c344d2b336a9410e28041e.json"}}], "type": "comparative study", "published": "2021-03-18", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "6357"}, "abstract": "The recent SARS-CoV-2 pandemic manifests itself as a mild respiratory tract infection in most individuals, leading to COVID-19 disease. However, in some infected individuals, this can progress to severe pneumonia and acute respiratory distress syndrome (ARDS), leading to multi-organ failure and death. This study explores the proteomic differences between mild, severe, and critical COVID-19 positive patients to further understand the disease progression, identify proteins associated with disease severity, and identify potential therapeutic targets. Blood protein profiling was performed on 59 COVID-19 mild (n = 26), severe (n = 9) or critical (n = 24) cases and 28 controls using the OLINK inflammation, autoimmune, cardiovascular and neurology panels. Differential expression analysis was performed within and between disease groups to generate nine different analyses. From the 368 proteins measured per individual, more than 75% were observed to be significantly perturbed in COVID-19 cases. Six proteins (IL6, CKAP4, Gal-9, IL-1ra, LILRB4 and PD-L1) were identified to be associated with disease severity. The results have been made readily available through an interactive web-based application for instant data exploration and visualization, and can be accessed at https://phidatalab-shiny.rosalind.kcl.ac.uk/COVID19/ . Our results demonstrate that dynamic changes in blood proteins associated with disease severity can potentially be used as early biomarkers to monitor disease severity in COVID-19 and serve as potential therapeutic targets.", "doi": "10.1038/s41598-021-85877-0", "pmid": "33737684", "labels": {"Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Biomarkers and systems immunology": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7973581"}, {"db": "pii", "key": "10.1038/s41598-021-85877-0"}], "notes": [], "created": "2020-11-11T06:47:50.601Z", "modified": "2023-06-19T14:41:38.563Z"}, {"entity": "publication", "iuid": "10d64921899648ee8b9c8e5d2b75d28f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/10d64921899648ee8b9c8e5d2b75d28f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/10d64921899648ee8b9c8e5d2b75d28f"}}, "title": "Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care.", "authors": [{"family": "Pillon", "given": "Nicolas J", "initials": "NJ"}, {"family": "Loos", "given": "Ruth J F", "initials": "RJF"}, {"family": "Marshall", "given": "Sally M", "initials": "SM"}, {"family": "Zierath", "given": "Juleen R", "initials": "JR"}], "type": "journal article", "published": "2021-03-18", "journal": {"title": "Cell", "issn": "1097-4172", "issn-l": "0092-8674", "volume": "184", "issue": "6", "pages": "1530-1544"}, "abstract": "The prevalence of type 2 diabetes and obesity has risen dramatically for decades and is expected to rise further, secondary to the growing aging, sedentary population. The strain on global health care is projected to be colossal. This review explores the latest work and emerging ideas related to genetic and environmental factors influencing metabolism. Translational research and clinical applications, including the impact of the COVID-19 pandemic, are highlighted. Looking forward, strategies to personalize all aspects of prevention, management and care are necessary to improve health outcomes and reduce the impact of these metabolic diseases.", "doi": "10.1016/j.cell.2021.02.012", "pmid": "33675692", "labels": {"Funder: VR": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0092-8674(21)00162-8"}], "notes": [], "created": "2021-03-08T10:47:30.864Z", "modified": "2021-11-18T11:57:32.775Z"}, {"entity": "publication", "iuid": "49040feeb8204cadb4e9d7acb2c4f66a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49040feeb8204cadb4e9d7acb2c4f66a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49040feeb8204cadb4e9d7acb2c4f66a"}}, "title": "Working from home during the COVID-19 outbreak in Sweden: effects on 24-h time-use in office workers.", "authors": [{"family": "Hallman", "given": "David M", "initials": "DM"}, {"family": "Januario", "given": "Leticia Bergamin", "initials": "LB"}, {"family": "Mathiassen", "given": "Svend Erik", "initials": "SE"}, {"family": "Heiden", "given": "Marina", "initials": "M"}, {"family": "Svensson", "given": "Sven", "initials": "S"}, {"family": "Bergstr\u00f6m", "given": "Gunnar", "initials": "G"}], "type": "journal article", "published": "2021-03-17", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "21", "issue": "1", "pages": "528"}, "abstract": "The COVID-19 pandemic has triggered national recommendations encouraging people to work from home (WFH), but the possible impact of WFH on physical behaviors is unknown. This study aimed to determine the extent to which the 24-h allocation of time to different physical behaviors changes between days working at the office (WAO) and days WFH in office workers during the pandemic.\r\n\r\nData were collected on 27 office workers with full-time employment at a Swedish municipal division during the COVID-19 outbreak in May-July 2020. A thigh-worn accelerometer (Axivity) was used to assess physical behavior (sedentary, stand, move) during seven consecutive days. A diary was used to identify periods of work, leisure and sleep. 24-h compositions of sedentary, standing and moving behaviors during work and non-work time were examined using Compositional data analysis (CoDA), and differences between days WAO and days WFH were determined using repeated measures ANOVA.\r\n\r\nDays WFH were associated with more time spent sleeping relative to awake, and the effect size was large (F = 7.4; p = 0.01; \u03b7 p2 = 0.22). The increase (34 min) in sleep time during WFH occurred at the expense of a reduction in work and leisure time by 26 min and 7 min, respectively. Sedentary, standing and moving behaviors did not change markedly during days WFH compared to days WAO.\r\n\r\nDays working from home during the COVID-19 pandemic in Sweden were associated with longer duration of sleep than days working at the office. This behavioral change may be beneficial to health.", "doi": "10.1186/s12889-021-10582-6", "pmid": "33731066", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-021-10582-6"}, {"db": "pmc", "key": "PMC7968563"}], "notes": [], "created": "2021-03-22T10:50:49.831Z", "modified": "2021-06-18T15:27:29.077Z"}, {"entity": "publication", "iuid": "1716a22867ba40bc9096731dff09d97c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1716a22867ba40bc9096731dff09d97c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1716a22867ba40bc9096731dff09d97c"}}, "title": "Assessment of protection against reinfection with SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020: a population-level observational study.", "authors": [{"family": "Hansen", "given": "Christian Holm", "initials": "CH"}, {"family": "Michlmayr", "given": "Daniela", "initials": "D"}, {"family": "Gubbels", "given": "Sophie Madeleine", "initials": "SM"}, {"family": "M\u00f8lbak", "given": "K\u00e5re", "initials": "K"}, {"family": "Ethelberg", "given": "Steen", "initials": "S"}], "type": "journal article", "published": "2021-03-17", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": null, "issue": null, "issn-l": "0140-6736"}, "abstract": "The degree to which infection with SARS-CoV-2 confers protection towards subsequent reinfection is not well described. In 2020, as part of Denmark's extensive, free-of-charge PCR-testing strategy, approximately 4 million individuals (69% of the population) underwent 10\u00b76 million tests. Using these national PCR-test data from 2020, we estimated protection towards repeat infection with SARS-CoV-2.\n\nIn this population-level observational study, we collected individual-level data on patients who had been tested in Denmark in 2020 from the Danish Microbiology Database and analysed infection rates during the second surge of the COVID-19 epidemic, from Sept 1 to Dec 31, 2020, by comparison of infection rates between individuals with positive and negative PCR tests during the first surge (March to May, 2020). For the main analysis, we excluded people who tested positive for the first time between the two surges and those who died before the second surge. We did an alternative cohort analysis, in which we compared infection rates throughout the year between those with and without a previous confirmed infection at least 3 months earlier, irrespective of date. We also investigated whether differences were found by age group, sex, and time since infection in the alternative cohort analysis. We calculated rate ratios (RRs) adjusted for potential confounders and estimated protection against repeat infection as 1 - RR.\n\nDuring the first surge (ie, before June, 2020), 533 381 people were tested, of whom 11 727 (2\u00b720%) were PCR positive, and 525 339 were eligible for follow-up in the second surge, of whom 11 068 (2\u00b711%) had tested positive during the first surge. Among eligible PCR-positive individuals from the first surge of the epidemic, 72 (0\u00b765% [95% CI 0\u00b751-0\u00b782]) tested positive again during the second surge compared with 16 819 (3\u00b727% [3\u00b722-3\u00b732]) of 514 271 who tested negative during the first surge (adjusted RR 0\u00b7195 [95% CI 0\u00b7155-0\u00b7246]). Protection against repeat infection was 80\u00b75% (95% CI 75\u00b74-84\u00b75). The alternative cohort analysis gave similar estimates (adjusted RR 0\u00b7212 [0\u00b7179-0\u00b7251], estimated protection 78\u00b78% [74\u00b79-82\u00b71]). In the alternative cohort analysis, among those aged 65 years and older, observed protection against repeat infection was 47\u00b71% (95% CI 24\u00b77-62\u00b78). We found no difference in estimated protection against repeat infection by sex (male 78\u00b74% [72\u00b71-83\u00b72] vs female 79\u00b71% [73\u00b79-83\u00b73]) or evidence of waning protection over time (3-6 months of follow-up 79\u00b73% [74\u00b74-83\u00b73] vs \u22657 months of follow-up 77\u00b77% [70\u00b79-82\u00b79]).\n\nOur findings could inform decisions on which groups should be vaccinated and advocate for vaccination of previously infected individuals because natural protection, especially among older people, cannot be relied on.\n\nNone.", "doi": "10.1016/S0140-6736(21)00575-4", "pmid": "33743221", "labels": {"Category: Public Health": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(21)00575-4"}], "notes": [], "created": "2021-03-22T10:13:10.682Z", "modified": "2021-03-22T10:13:10.692Z"}, {"entity": "publication", "iuid": "7f2312c9703141e0992299306a9f8e5e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f2312c9703141e0992299306a9f8e5e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f2312c9703141e0992299306a9f8e5e"}}, "title": "Virological and immunological features of SARS-CoV-2-infected children who develop neutralizing antibodies.", "authors": [{"family": "Cotugno", "given": "Nicola", "initials": "N"}, {"family": "Ruggiero", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-1041-7489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e47b6216d0514a37818f676dce75ff57.json"}}, {"family": "Bonfante", "given": "Francesco", "initials": "F"}, {"family": "Petrara", "given": "Maria Raffaella", "initials": "MR"}, {"family": "Zicari", "given": "Sonia", "initials": "S", "orcid": "0000-0003-1240-8057", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0379fd354fd3492aa5d5fe8ea9e16065.json"}}, {"family": "Pascucci", "given": "Giuseppe Rubens", "initials": "GR", "orcid": "0000-0002-5978-1193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cfa33536b1242949e2195412e11f541.json"}}, {"family": "Zangari", "given": "Paola", "initials": "P"}, {"family": "De Ioris", "given": "Maria Antonietta", "initials": "MA"}, {"family": "Santilli", "given": "Veronica", "initials": "V"}, {"family": "Manno", "given": "E C", "initials": "EC"}, {"family": "Amodio", "given": "Donato", "initials": "D", "orcid": "0000-0003-4550-3018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8036babccffd453ab3dda55c13a204fa.json"}}, {"family": "Bortolami", "given": "Alessio", "initials": "A"}, {"family": "Pagliari", "given": "Matteo", "initials": "M"}, {"family": "Concato", "given": "Carlo", "initials": "C"}, {"family": "Linardos", "given": "Giulia", "initials": "G"}, {"family": "Campana", "given": "Andrea", "initials": "A"}, {"family": "Don\u00e0", "given": "Daniele", "initials": "D"}, {"family": "Giaquinto", "given": "Carlo", "initials": "C"}, {"family": "CACTUS Study Team", "given": "", "initials": ""}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}, {"family": "Rossi", "given": "Paolo", "initials": "P"}, {"family": "De Rossi", "given": "Anita", "initials": "A", "orcid": "0000-0001-6435-7509", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a4a32409ace4604983c5773c28c7c9e.json"}}, {"family": "Palma", "given": "Paolo", "initials": "P", "orcid": "0000-0002-3066-4719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36e1a02e86a142c2b2d131154fb46f1c.json"}}], "type": "journal article", "published": "2021-03-16", "journal": {"title": "Cell Rep", "issn": "2211-1247", "volume": "34", "issue": "11", "pages": "108852", "issn-l": null}, "abstract": "As the global COVID-19 pandemic progresses, it is paramount to gain knowledge on adaptive immunity to SARS-CoV-2 in children to define immune correlates of protection upon immunization or infection. We analyzed anti-SARS-CoV-2 antibodies and their neutralizing activity (PRNT) in 66 COVID-19-infected children at 7 (\u00b12) days after symptom onset. Individuals with specific humoral responses presented faster virus clearance and lower viral load associated with a reduced in vitro infectivity. We demonstrated that the frequencies of SARS-CoV-2-specific CD4+CD40L+ T cells and Spike-specific B cells were associated with the anti-SARS-CoV-2 antibodies and the magnitude of neutralizing activity. The plasma proteome confirmed the association between cellular and humoral SARS-CoV-2 immunity, and PRNT+ patients show higher viral signal transduction molecules (SLAMF1, CD244, CLEC4G). This work sheds lights on cellular and humoral anti-SARS-CoV-2 responses in children, which may drive future vaccination trial endpoints and quarantine measures policies.", "doi": "10.1016/j.celrep.2021.108852", "pmid": "33730580", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7962998"}, {"db": "pii", "key": "S2211-1247(21)00166-2"}], "notes": [], "created": "2021-03-22T10:53:29.904Z", "modified": "2023-06-19T15:18:16.124Z"}, {"entity": "publication", "iuid": "bcf96a7cfc6548a3b5054f75641dca84", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bcf96a7cfc6548a3b5054f75641dca84.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bcf96a7cfc6548a3b5054f75641dca84"}}, "title": "Impact of COVID-19 pandemic on utilisation of healthcare services: a systematic review.", "authors": [{"family": "Moynihan", "given": "Ray", "initials": "R"}, {"family": "Sanders", "given": "Sharon", "initials": "S"}, {"family": "Michaleff", "given": "Zoe A", "initials": "ZA"}, {"family": "Scott", "given": "Anna Mae", "initials": "AM"}, {"family": "Clark", "given": "Justin", "initials": "J"}, {"family": "To", "given": "Emma J", "initials": "EJ"}, {"family": "Jones", "given": "Mark", "initials": "M"}, {"family": "Kitchener", "given": "Eliza", "initials": "E"}, {"family": "Fox", "given": "Melissa", "initials": "M"}, {"family": "Johansson", "given": "Minna", "initials": "M"}, {"family": "Lang", "given": "Eddy", "initials": "E"}, {"family": "Duggan", "given": "Anne", "initials": "A"}, {"family": "Scott", "given": "Ian", "initials": "I"}, {"family": "Albarqouni", "given": "Loai", "initials": "L"}], "type": "journal article", "published": "2021-03-16", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "3", "pages": "e045343", "issn-l": "2044-6055"}, "abstract": "To determine the extent and nature of changes in utilisation of healthcare services during COVID-19 pandemic.\n\nSystematic review.\n\nEligible studies compared utilisation of services during COVID-19 pandemic to at least one comparable period in prior years. Services included visits, admissions, diagnostics and therapeutics. Studies were excluded if from single centres or studied only patients with COVID-19.\n\nPubMed, Embase, Cochrane COVID-19 Study Register and preprints were searched, without language restrictions, until 10 August, using detailed searches with key concepts including COVID-19, health services and impact.\n\nRisk of bias was assessed by adapting the Risk of Bias in Non-randomised Studies of Interventions tool, and a Cochrane Effective Practice and Organization of Care tool. Results were analysed using descriptive statistics, graphical figures and narrative synthesis.\n\nPrimary outcome was change in service utilisation between prepandemic and pandemic periods. Secondary outcome was the change in proportions of users of healthcare services with milder or more severe illness (eg, triage scores).\n\n3097 unique references were identified, and 81 studies across 20 countries included, reporting on >11 million services prepandemic and 6.9 million during pandemic. For the primary outcome, there were 143 estimates of changes, with a median 37% reduction in services overall (IQR -51% to -20%), comprising median reductions for visits of 42% (-53% to -32%), admissions 28% (-40% to -17%), diagnostics 31% (-53% to -24%) and for therapeutics 30% (-57% to -19%). Among 35 studies reporting secondary outcomes, there were 60 estimates, with 27 (45%) reporting larger reductions in utilisation among people with a milder spectrum of illness, and 33 (55%) reporting no difference.\n\nHealthcare utilisation decreased by about a third during the pandemic, with considerable variation, and with greater reductions among people with less severe illness. While addressing unmet need remains a priority, studies of health impacts of reductions may help health systems reduce unnecessary care in the postpandemic recovery.\n\nCRD42020203729.", "doi": "10.1136/bmjopen-2020-045343", "pmid": "33727273", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-045343"}, {"db": "pmc", "key": "PMC7969768"}], "notes": [], "created": "2021-03-22T11:33:37.299Z", "modified": "2021-03-22T11:33:47.567Z"}, {"entity": "publication", "iuid": "b55606ceb58b4ef0a6080dc2afa9ee50", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b55606ceb58b4ef0a6080dc2afa9ee50.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b55606ceb58b4ef0a6080dc2afa9ee50"}}, "title": "COVIDENZA - A prospective, multicenter, randomized PHASE II clinical trial of enzalutamide treatment to decrease the morbidity in patients with Corona virus disease 2019 (COVID-19): a structured summary of a study protocol for a randomised controlled trial.", "authors": [{"family": "Wel\u00e9n", "given": "Karin", "initials": "K"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Freyhult", "given": "Eva", "initials": "E"}, {"family": "Robinsson", "given": "David", "initials": "D"}, {"family": "Henningsson", "given": "Anna Jonsson", "initials": "AJ"}, {"family": "Stranne", "given": "Johan", "initials": "J"}, {"family": "Bremell", "given": "Daniel", "initials": "D"}, {"family": "Angelin", "given": "Martin", "initials": "M"}, {"family": "Lindquist", "given": "Elisabeth", "initials": "E"}, {"family": "Buckland", "given": "Robert", "initials": "R"}, {"family": "Carlsson", "given": "Camilla Thellenberg", "initials": "CT"}, {"family": "Pauksens", "given": "Karlis", "initials": "K"}, {"family": "Bill-Axelsson", "given": "Anna", "initials": "A"}, {"family": "Akre", "given": "Olof", "initials": "O"}, {"family": "Ryden", "given": "Cecilia", "initials": "C"}, {"family": "Wagenius", "given": "Magnus", "initials": "M"}, {"family": "Bjartell", "given": "Anders", "initials": "A"}, {"family": "Nilsson", "given": "Anna C", "initials": "AC"}, {"family": "Styrke", "given": "Johan", "initials": "J"}, {"family": "Repo", "given": "Johanna", "initials": "J"}, {"family": "Balkhed", "given": "\u00c5se \u00d6stholm", "initials": "\u00c5\u00d6"}, {"family": "Niward", "given": "Katarina", "initials": "K"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Josefsson", "given": "Andreas", "initials": "A"}], "type": "letter", "published": "2021-03-16", "journal": {"title": "Trials", "issn": "1745-6215", "issn-l": null, "volume": "22", "issue": "1", "pages": "209"}, "abstract": "The main goal of the COVIDENZA trial is to evaluate if inhibition of testosterone signalling by enzalutamide can improve the outcome of patients hospitalised for COVID-19. The hypothesis is based on the observation that the majority of patients in need of intensive care are male, and the connection between androgen receptor signalling and expression of TMPRSS2, an enzyme important for SARS-CoV-2 host cell internalization.\r\n\r\nHospitalised COVID-19 patients will be randomised (2:1) to enzalutamide plus standard of care vs. standard of care designed to identify superiority.\r\n\r\nIncluded participants, men or women above 50 years of age, must be hospitalised for PCR confirmed COVID-19 symptoms and not in need of immediate mechanical ventilation. Major exclusion criteria are breast-feeding or pregnant women, hormonal treatment for prostate or breast cancer, treatment with immunosuppressive drugs, current symptomatic unstable cardiovascular disease (see Additional file 1 for further details). The trial is registered at Ume\u00e5 University Hospital, Region V\u00e4sterbotten, Sweden and 8 hospitals are approved for inclusion in Sweden.\r\n\r\nPatients randomised to the treatment arm will be treated orally with 160 mg (4x40 mg) enzalutamide (Xtandi\u00ae) daily, for five consecutive days. The study is not placebo controlled. The comparator is standard of care treatment for patients hospitalised with COVID-19.\r\n\r\nThe primary endpoints of the study are (time to) need of mechanical ventilation or discharge from hospital as assessed by a clinical 7-point ordinal scale (up to 30 days after inclusion).\r\n\r\nRandomisation was stratified by center and sex. Each strata was randomized separately with block size six with a 2:1 allocation ratio (enzalutamide + \"standard of care\": \"standard of care\"). The randomisation list, with consecutive subject numbers, was generated by an independent statistician using the PROC PLAN procedure of SAS version 9.4 software (SAS Institute, Inc, Cary, North Carolina) BLINDING (MASKING): This is an open-label trial.\r\n\r\nThe trial is designed to have three phases. The first, an exploration phase of 45 participants (30 treatment and 15 control) will focus on safety and includes a more extensive laboratory assessment as well as more frequent safety evaluation. The second prolongation phase, includes the first 100 participants followed by an interim analysis to define the power of the study. The third phase is the continuation of the study up to maximum 600 participants included in total.\r\n\r\nThe current protocol version is COVIDENZA v2.0 as of September 10, 2020. Recruitment started July 29, 2020 and is presently in safety pause after the first exploration phase. Recruitment is anticipated to be complete by 31 December 2021.\r\n\r\nEudract number 2020-002027-10 ClinicalTrials.gov Identifier: NCT04475601 , registered June 8, 2020 FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.", "doi": "10.1186/s13063-021-05137-4", "pmid": "33726804", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13063-021-05137-4"}, {"db": "pmc", "key": "PMC7961321"}, {"db": "ClinicalTrials.gov", "key": "NCT04475601"}], "notes": [], "created": "2021-03-22T11:34:31.938Z", "modified": "2021-04-26T17:39:07.975Z"}, {"entity": "publication", "iuid": "a7368389e0b64b0f98a017d224b876f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7368389e0b64b0f98a017d224b876f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7368389e0b64b0f98a017d224b876f1"}}, "title": "COVID-19 vaccine guidance for patients with cancer participating in oncology clinical trials.", "authors": [{"family": "Desai", "given": "Aakash", "initials": "A"}, {"family": "Gainor", "given": "Justin F", "initials": "JF"}, {"family": "Hegde", "given": "Aparna", "initials": "A"}, {"family": "Schram", "given": "Alison M", "initials": "AM"}, {"family": "Curigiliano", "given": "Guiseppe", "initials": "G"}, {"family": "Pal", "given": "Sumanta", "initials": "S"}, {"family": "Liu", "given": "Stephen V", "initials": "SV"}, {"family": "Halmos", "given": "Balazs", "initials": "B"}, {"family": "Groisberg", "given": "Roman", "initials": "R"}, {"family": "Grande", "given": "Enrique", "initials": "E"}, {"family": "Dragovich", "given": "Tomislav", "initials": "T"}, {"family": "Matrana", "given": "Marc", "initials": "M"}, {"family": "Agarwal", "given": "Neeraj", "initials": "N"}, {"family": "Chawla", "given": "Sant", "initials": "S"}, {"family": "Kato", "given": "Shumei", "initials": "S"}, {"family": "Morgan", "given": "Gilberto", "initials": "G"}, {"family": "Kasi", "given": "Pashtoon M", "initials": "PM"}, {"family": "Solomon", "given": "Benjamin", "initials": "B"}, {"family": "Loong", "given": "Herbert H", "initials": "HH"}, {"family": "Park", "given": "Haeseong", "initials": "H"}, {"family": "Choueiri", "given": "Toni K", "initials": "TK"}, {"family": "Subbiah", "given": "Ishwaria M", "initials": "IM"}, {"family": "Pemmaraju", "given": "Naveen", "initials": "N"}, {"family": "Subbiah", "given": "Vivek", "initials": "V"}, {"family": "COVID19 and Cancer Clinical Trials Working Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-03-15", "journal": {"title": "Nat Rev Clin Oncol", "issn": "1759-4782", "volume": null, "issue": null, "issn-l": null}, "abstract": "Emerging efficacy data have led to the emergency use authorization or approval of COVID-19 vaccines in several countries worldwide. Most trials of COVID-19 vaccines excluded patients with active malignancies, and thus data on the safety, tolerability and efficacy of the vaccines in patients with cancer are currently limited. Given the risk posed by the COVID-19 pandemic, decisions regarding the use of vaccines against COVID-19 in patients participating in trials of investigational anticancer therapies need to be addressed promptly. Patients should not have to choose between enrolling on oncology clinical trials and receiving a COVID-19 vaccine. Clinical trial sponsors, investigators and treating physicians need operational guidance on COVID-19 vaccination for patients with cancer who are currently enrolled or might seek to enrol in clinical trials. Considering the high morbidity and mortality from COVID-19 in patients with cancer, the benefits of vaccination are likely to far outweigh the risks of vaccine-related adverse events. Herein, we provide operational COVID-19 vaccine guidance for patients participating in oncology clinical trials. In our perspective, continued quality oncological care requires that patients with cancer, including those involved in trials, be prioritized for COVID-19 vaccination, which should not affect trial eligibility.", "doi": "10.1038/s41571-021-00487-z", "pmid": "33723371", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41571-021-00487-z"}], "notes": [], "created": "2021-03-17T07:43:19.672Z", "modified": "2021-03-22T11:39:43.055Z"}, {"entity": "publication", "iuid": "900795e8be414da9a5320172e73e4ed4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/900795e8be414da9a5320172e73e4ed4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/900795e8be414da9a5320172e73e4ed4"}}, "title": "Cardiac arrest in COVID-19: characteristics and outcomes of in- and out-of-hospital cardiac arrest. A report from the Swedish Registry for Cardiopulmonary Resuscitation", "authors": [{"family": "Sultanian", "given": "Pedram", "initials": "P"}, {"family": "Lundgren", "given": "Peter", "initials": "P"}, {"family": "Str\u00f6ms\u00f6e", "given": "Anneli", "initials": "A"}, {"family": "Aune", "given": "Solveig", "initials": "S"}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G"}, {"family": "Hagberg", "given": "Eva", "initials": "E"}, {"family": "Hollenberg", "given": "Jacob", "initials": "J"}, {"family": "Lindqvist", "given": "Jonny", "initials": "J"}, {"family": "Dj\u00e4rv", "given": "Therese", "initials": "T"}, {"family": "Castelheim", "given": "Albert", "initials": "A"}, {"family": "Thor\u00e9n", "given": "Anna", "initials": "A"}, {"family": "Hessulf", "given": "Fredrik", "initials": "F"}, {"family": "Svensson", "given": "Leif", "initials": "L"}, {"family": "Claesson", "given": "Andreas", "initials": "A"}, {"family": "Friberg", "given": "Hans", "initials": "H"}, {"family": "Nordberg", "given": "Per", "initials": "P"}, {"family": "Omerovic", "given": "Elmir", "initials": "E"}, {"family": "Rosengren", "given": "Annika", "initials": "A"}, {"family": "Herlitz", "given": "Johan", "initials": "J"}, {"family": "Rawshani", "given": "Araz", "initials": "A"}], "type": "journal-article", "published": "2021-03-14", "journal": {"title": "Eur Heart J", "issn": "0195-668X", "issn-l": null, "volume": "42", "issue": "11", "pages": "1094-1106"}, "abstract": null, "doi": "10.1093/eurheartj/ehaa1067", "pmid": null, "labels": {"Funder: Hj\u00e4rt-Lungfonden": null, "Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-25T17:10:04.621Z", "modified": "2021-06-18T15:26:06.336Z"}, {"entity": "publication", "iuid": "50db707ebaa94540b6b438f659d837fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50db707ebaa94540b6b438f659d837fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50db707ebaa94540b6b438f659d837fa"}}, "title": "Persistence of SARS-CoV-2-specific B and T cell responses in convalescent COVID-19 patients 6-8 months after the infection.", "authors": [{"family": "Sherina", "given": "Natalia", "initials": "N"}, {"family": "Piralla", "given": "Antonio", "initials": "A"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Wan", "given": "Hui", "initials": "H"}, {"family": "Kumagai-Braesch", "given": "Makiko", "initials": "M"}, {"family": "Andr\u00e9ll", "given": "Juni", "initials": "J"}, {"family": "Braesch-Andersen", "given": "Sten", "initials": "S"}, {"family": "Cassaniti", "given": "Irene", "initials": "I"}, {"family": "Percivalle", "given": "Elena", "initials": "E"}, {"family": "Sarasini", "given": "Antonella", "initials": "A"}, {"family": "Bergami", "given": "Federica", "initials": "F"}, {"family": "Di Martino", "given": "Raffaella", "initials": "R"}, {"family": "Colaneri", "given": "Marta", "initials": "M"}, {"family": "Vecchia", "given": "Marco", "initials": "M"}, {"family": "Sambo", "given": "Margherita", "initials": "M"}, {"family": "Zuccaro", "given": "Valentina", "initials": "V"}, {"family": "Bruno", "given": "Raffaele", "initials": "R"}, {"family": "Sachs", "given": "Michele", "initials": "M"}, {"family": "Oggionni", "given": "Tiberio", "initials": "T"}, {"family": "Meloni", "given": "Federica", "initials": "F"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Bertoglio", "given": "Federico", "initials": "F"}, {"family": "Schubert", "given": "Maren", "initials": "M"}, {"family": "Byrne-Steele", "given": "Miranda", "initials": "M"}, {"family": "Han", "given": "Jian", "initials": "J"}, {"family": "Hust", "given": "Michael", "initials": "M"}, {"family": "Xue", "given": "Yintong", "initials": "Y"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}], "type": "journal article", "published": "2021-03-12", "journal": {"title": "Med (N Y)", "issn": "2666-6340", "issn-l": null, "volume": "2", "issue": "3", "pages": "281-295.e4"}, "abstract": "Monitoring the adaptive immune responses during the natural course of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection provides useful information for the development of vaccination strategies against this virus and its emerging variants. We thus profiled the serum anti-SARS-CoV-2 antibody (Ab) levels and specific memory B and T cell responses in convalescent coronavirus disease 2019 (COVID-19) patients.\n\nA total of 119 samples from 88 convalescent donors who experienced mild to critical disease were tested for the presence of elevated anti-spike and anti-receptor binding domain Ab levels over a period of 8 months. In addition, the levels of SARS-CoV-2 neutralizing Abs and specific memory B and T cell responses were tested in a subset of samples.\n\nAnti-SARS-CoV-2 Abs were present in 85% of the samples collected within 4 weeks after the onset of symptoms in COVID-19 patients. Levels of specific immunoglobulin M (IgM)/IgA Abs declined after 1 month, while levels of specific IgG Abs and plasma neutralizing activities remained relatively stable up to 6 months after diagnosis. Anti-SARS-CoV-2 IgG Abs were still present, although at a significantly lower level, in 80% of the samples collected at 6-8 months after symptom onset. SARS-CoV-2-specific memory B and T cell responses developed with time and were persistent in all of the patients followed up for 6-8 months.\n\nOur data suggest that protective adaptive immunity following natural infection of SARS-CoV-2 may persist for at least 6-8 months, regardless of disease severity. Development of medium- or long-term protective immunity through vaccination may thus be possible.\n\nThis project was supported by the European Union's Horizon 2020 research and innovation programme (ATAC, no. 101003650), the Italian Ministry of Health (Ricerca Finalizzata grant no. GR-2013-02358399), the Center for Innovative Medicine, and the Swedish Research Council. J.A. was supported by the SciLifeLab/KAW national COVID-19 research program project grant 2020.", "doi": "10.1016/j.medj.2021.02.001", "pmid": "33589885", "labels": {"Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Category: Health": null, "Type: Journal article": null, "Research Area: High-throughput and high-content serology": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "S2666-6340(21)00038-6"}, {"db": "pmc", "key": "PMC7874960"}], "notes": [], "created": "2021-02-17T14:55:48.819Z", "modified": "2021-12-12T18:07:23.858Z"}, {"entity": "publication", "iuid": "79aa0ace4ea74d2080d6c5bdc0c42be7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79aa0ace4ea74d2080d6c5bdc0c42be7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79aa0ace4ea74d2080d6c5bdc0c42be7"}}, "title": "Oxygen provision to severely ill COVID-19 patients at the peak of the 2020 pandemic in a Swedish district hospital", "authors": [{"family": "Hvarfner", "given": "Anna", "initials": "A"}, {"family": "Al-Djaber", "given": "Ahmed", "initials": "A"}, {"family": "Ekstrom", "given": "Hampus", "initials": "H"}, {"family": "Enarsson", "given": "Malin", "initials": "M"}, {"family": "Castegren", "given": "Markus", "initials": "M"}, {"family": "Baker", "given": "Tim", "initials": "T"}, {"family": "Schell", "given": "Carl Otto", "initials": "CO"}], "type": "posted-content", "published": "2021-03-12", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.11.21253350", "pmid": null, "labels": {"Category: Health": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-03-25T14:04:28.506Z", "modified": "2021-03-31T08:20:11.539Z"}, {"entity": "publication", "iuid": "bb5ddc2c0e004a5a8558b2c87b6026d3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb5ddc2c0e004a5a8558b2c87b6026d3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb5ddc2c0e004a5a8558b2c87b6026d3"}}, "title": "Mapping the human genetic architecture of COVID-19 by worldwide meta-analysis", "authors": [{"family": null, "given": "", "initials": ""}, {"family": "Ganna", "given": "Andrea", "initials": "A", "orcid": "0000-0002-8147-240X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2b7f6041889a4ebbab284d4ea5647a50.json"}}], "type": "posted-content", "published": "2021-03-12", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.10.21252820", "pmid": null, "labels": {"Category: Genomics & transcriptomics": null, "Type: Preprint": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "URL", "key": "https://www.covid19hg.org/results/r5/", "description": "Summary statistics generated by COVID-19 HGI"}, {"db": "URL", "key": "https://github.com/marcoralab/MRcovid", "description": "Code for Mendelian randomization and genetic correlation pipeline"}, {"db": "URL", "key": "https://github.com/covid19-hg/", "description": "Code for summary statistics liftover and meta-analysis and PCA pipeline"}], "notes": [], "created": "2021-03-15T17:29:56.885Z", "modified": "2022-02-06T17:38:55.641Z"}, {"entity": "publication", "iuid": "051c1aac317d46c08affde26d18af82b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/051c1aac317d46c08affde26d18af82b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/051c1aac317d46c08affde26d18af82b"}}, "title": "Indoor Model Simulation for COVID-19 Transport and Exposure.", "authors": [{"family": "Hussein", "given": "Tareq", "initials": "T"}, {"family": "L\u00f6ndahl", "given": "Jakob", "initials": "J"}, {"family": "Thuresson", "given": "Sara", "initials": "S"}, {"family": "Alsved", "given": "Malin", "initials": "M"}, {"family": "Al-Hunaiti", "given": "Afnan", "initials": "A"}, {"family": "Saksela", "given": "Kalle", "initials": "K"}, {"family": "Aqel", "given": "Hazem", "initials": "H"}, {"family": "Junninen", "given": "Heikki", "initials": "H"}, {"family": "Mahura", "given": "Alexander", "initials": "A"}, {"family": "Kulmala", "given": "Markku", "initials": "M"}], "type": "journal article", "published": "2021-03-12", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "6", "pages": null}, "abstract": "Transmission of respiratory viruses is a complex process involving emission, deposition in the airways, and infection. Inhalation is often the most relevant transmission mode in indoor environments. For severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the risk of inhalation transmission is not yet fully understood. Here, we used an indoor aerosol model combined with a regional inhaled deposited dose model to examine the indoor transport of aerosols from an infected person with novel coronavirus disease (COVID-19) to a susceptible person and assess the potential inhaled dose rate of particles. Two scenarios with different ventilation rates were compared, as well as adult female versus male recipients. Assuming a source strength of 10 viruses/s, in a tightly closed room with poor ventilation (0.5 h -1), the respiratory tract deposited dose rate was 140-350 and 100-260 inhaled viruses/hour for males and females; respectively. With ventilation at 3 h-1 the dose rate was only 30-90 viruses/hour. Correcting for the half-life of SARS-CoV-2 in air, these numbers are reduced by a factor of 1.2-2.2 for poorly ventilated rooms and 1.1-1.4 for well-ventilated rooms. Combined with future determinations of virus emission rates, the size distribution of aerosols containing the virus, and the infectious dose, these results could play an important role in understanding the full picture of potential inhalation transmission in indoor environments.", "doi": "10.3390/ijerph18062927", "pmid": "33809366", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Public Health": null, "Funder: H2020": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [{"db": "pii", "key": "ijerph18062927"}], "notes": [], "created": "2021-04-06T10:28:30.739Z", "modified": "2021-06-18T15:24:59.028Z"}, {"entity": "publication", "iuid": "57b0f4e9731f4829b69f86301d0eb285", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/57b0f4e9731f4829b69f86301d0eb285.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/57b0f4e9731f4829b69f86301d0eb285"}}, "title": "Does reactivation of cytomegalovirus contribute to severe COVID-19 disease?", "authors": [{"family": "S\u00f6derberg-Naucl\u00e9r", "given": "Cecilia", "initials": "C"}], "type": "letter", "published": "2021-03-12", "journal": {"title": "Immun Ageing", "issn": "1742-4933", "volume": "18", "issue": "1", "pages": "12", "issn-l": null}, "abstract": "The majority of people infected with SARS-CoV-2 are asymptomatic or have mild to moderate symptoms. However, for unknown reasons, about 15 % have severe pneumonia requiring hospital care and oxygen support, and about 5 % develop acute respiratory distress syndrome, septic shock, and multiorgan failure that result in a high mortality rate. The risk of severe COVID-19 is highest among those who are over 70 years of age. Why severe COVID-19 develops in some people but not others is not understood. Could some cases involve reactivation of latent cytomegalovirus (CMV)?", "doi": "10.1186/s12979-021-00218-z", "pmid": "33712035", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12979-021-00218-z"}, {"db": "pmc", "key": "PMC7952506"}], "notes": [], "created": "2021-03-17T07:17:39.389Z", "modified": "2021-03-17T07:17:39.410Z"}, {"entity": "publication", "iuid": "0fda30da2de8474d9d7951b107e01343", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0fda30da2de8474d9d7951b107e01343.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0fda30da2de8474d9d7951b107e01343"}}, "title": "Disparities in COVID-19 deaths by country of birth in Stockholm, Sweden: A total population based cohort study.", "authors": [{"family": "Rostila", "given": "Mikael", "initials": "M"}, {"family": "Cederstr\u00f6m", "given": "Agneta", "initials": "A"}, {"family": "Wallace", "given": "Matthew", "initials": "M"}, {"family": "Brand\u00e9n", "given": "Maria", "initials": "M"}, {"family": "Malmberg", "given": "Bo", "initials": "B"}, {"family": "Andersson", "given": "Gunnar", "initials": "G"}], "type": "journal article", "published": "2021-03-12", "journal": {"title": "Am J Epidemiol", "issn": "1476-6256", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Preliminary evidence points to higher morbidity and mortality of COVID-19 in certain racial and ethnic groups but population-based studies using micro-level data are so far lacking. A register-based cohort including all adults living in Stockholm, Sweden (n=1,778,670) between January 31st (date of first confirmed case of COVID-19) and May 4th 2020 was utilized. Poisson regressions with region/country of birth as exposure and underlying cause of death by COVID-19 as outcome was performed, estimating relative risks (RR) and confidence intervals (CI). Migrants from Middle-Eastern countries (RR 3.2, 95% CI: 2.6-3.8), Africa (RR 3.0, 95% CI: 2.2-4.3) and the Nordic countries (RR 1.5, 95% CI: 1.2-1.8) had higher mortality in COVID-19 when compared to Swedish born. Especially high mortality risks from COVID-19 was found among individuals born in Somalia, Lebanon, Syria, Turkey, Iran and Iraq. Socioeconomic status, number of working age household members and neighborhood population density attenuated up to half of the increased COVID-19 mortality risks among foreign born. Disadvantaged socioeconomic and living conditions may increase infection rates in migrants and contribute to their higher COVID-19 mortality risk.", "doi": "10.1093/aje/kwab057", "pmid": "33710317", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6168677"}], "notes": [], "created": "2021-03-17T07:16:08.894Z", "modified": "2021-06-18T15:22:46.753Z"}, {"entity": "publication", "iuid": "ed5b25234cba4f13b74f1d73fda2a894", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed5b25234cba4f13b74f1d73fda2a894.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed5b25234cba4f13b74f1d73fda2a894"}}, "title": "Could a good night's sleep improve COVID-19 vaccine efficacy?", "authors": [{"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J"}], "type": "journal article", "published": "2021-03-12", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "volume": null, "issue": null, "issn-l": "2213-2600"}, "abstract": null, "doi": "10.1016/S2213-2600(21)00126-0", "pmid": "33721558", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(21)00126-0"}], "notes": [], "created": "2021-03-17T07:45:00.431Z", "modified": "2021-03-22T11:44:11.630Z"}, {"entity": "publication", "iuid": "bfc7cd9b29f3455f9279026840d26993", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bfc7cd9b29f3455f9279026840d26993.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bfc7cd9b29f3455f9279026840d26993"}}, "title": "[Tracheotomy earlier than recommended among patients with Covid-19].", "authors": [{"family": "Nihl\u00e9n", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Odhagen", "given": "Erik", "initials": "E"}, {"family": "Lindell", "given": "Ellen", "initials": "E"}], "type": "journal article", "published": "2021-03-11", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "volume": "118", "issue": null, "issn-l": "0023-7205"}, "abstract": "The outbreak of SARS-CoV-2 has led to a sharp rise in intensive care unit (ICU) admissions and consequently a need to perform tracheotomies on patients with Covid-19. A number of guidelines have been published with recommendations for the timing of tracheostomy in Covid-19 patients, suggesting tracheotomy should be delayed until day 14-21 of mechanical ventilation. We present the first 66 patients treated in the ICU at S\u00f6dra \u00c4lvsborg hospital in Sweden as a result of Covid-19. A total of 29 patients received a tracheostomy, median time 9 days post oral intubation, which is earlier than recommended. The mortality rate was 21%, which is slightly lower than reported from The Swedish Intensive Care Registry (25%). None of the doctors performing tracheotomies developed Covid-19 linked to the tracheotomy procedure.", "doi": null, "pmid": "33709387", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "20232"}], "notes": [], "created": "2021-03-17T07:18:22.056Z", "modified": "2021-03-17T07:41:15.135Z"}, {"entity": "publication", "iuid": "08edf7c7a48448198e50b7c786f8cb50", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/08edf7c7a48448198e50b7c786f8cb50.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/08edf7c7a48448198e50b7c786f8cb50"}}, "title": "The battle for COVID-19 vaccines highlights the need for a new global governance mechanism.", "authors": [{"family": "Ekstr\u00f6m", "given": "Anna Mia", "initials": "AM"}, {"family": "Berggren", "given": "Camilla", "initials": "C"}, {"family": "Tomson", "given": "G\u00f6ran", "initials": "G"}, {"family": "Gostin", "given": "Lawrence O", "initials": "LO"}, {"family": "Friberg", "given": "Peter", "initials": "P"}, {"family": "Ottersen", "given": "Ole Petter", "initials": "OP"}], "type": "letter", "published": "2021-03-11", "journal": {"title": "Nat Med", "issn": "1546-170X", "volume": null, "issue": null, "issn-l": "1078-8956"}, "abstract": null, "doi": "10.1038/s41591-021-01288-8", "pmid": "33707776", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-021-01288-8"}], "notes": [], "created": "2021-03-17T07:20:39.660Z", "modified": "2021-03-17T07:20:39.669Z"}, {"entity": "publication", "iuid": "de451ac94d164bf5b45bf034a5c04d1c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/de451ac94d164bf5b45bf034a5c04d1c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/de451ac94d164bf5b45bf034a5c04d1c"}}, "title": "Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers.", "authors": [{"family": "Danlos", "given": "Fran\u00e7ois-Xavier", "initials": "FX"}, {"family": "Grajeda-Iglesias", "given": "Claudia", "initials": "C"}, {"family": "Durand", "given": "Sylv\u00e8re", "initials": "S"}, {"family": "Sauvat", "given": "Allan", "initials": "A"}, {"family": "Roumier", "given": "Mathilde", "initials": "M"}, {"family": "Cantin", "given": "Delphine", "initials": "D"}, {"family": "Colomba", "given": "Emeline", "initials": "E"}, {"family": "Rohmer", "given": "Julien", "initials": "J"}, {"family": "Pommeret", "given": "Fanny", "initials": "F"}, {"family": "Baciarello", "given": "Giulia", "initials": "G"}, {"family": "Willekens", "given": "Christophe", "initials": "C"}, {"family": "Vasse", "given": "Marc", "initials": "M"}, {"family": "Griscelli", "given": "Frank", "initials": "F"}, {"family": "Fahrner", "given": "Jean-Eudes", "initials": "JE"}, {"family": "Goubet", "given": "Anne-Ga\u00eblle", "initials": "AG"}, {"family": "Dubuisson", "given": "Agathe", "initials": "A"}, {"family": "Derosa", "given": "Lisa", "initials": "L"}, {"family": "Nirmalathasan", "given": "Nitharsshini", "initials": "N"}, {"family": "Bredel", "given": "Delphine", "initials": "D"}, {"family": "Mouraud", "given": "S\u00e9verine", "initials": "S"}, {"family": "Pradon", "given": "Caroline", "initials": "C"}, {"family": "Stoclin", "given": "Annabelle", "initials": "A"}, {"family": "Rozenberg", "given": "Flore", "initials": "F"}, {"family": "Duchemin", "given": "J\u00e9r\u00f4me", "initials": "J"}, {"family": "Jourdi", "given": "Georges", "initials": "G"}, {"family": "Ellouze", "given": "Syrine", "initials": "S"}, {"family": "Levavasseur", "given": "Fran\u00e7oise", "initials": "F"}, {"family": "Albig\u00e8s", "given": "Laurence", "initials": "L"}, {"family": "Soria", "given": "Jean-Charles", "initials": "JC"}, {"family": "Barlesi", "given": "Fabrice", "initials": "F"}, {"family": "Solary", "given": "Eric", "initials": "E"}, {"family": "Andr\u00e9", "given": "Fabrice", "initials": "F"}, {"family": "P\u00e8ne", "given": "Fr\u00e9d\u00e9ric", "initials": "F"}, {"family": "Ackerman", "given": "F\u00e9lix", "initials": "F"}, {"family": "Mouthon", "given": "Luc", "initials": "L"}, {"family": "Zitvogel", "given": "Laurence", "initials": "L"}, {"family": "Marabelle", "given": "Aur\u00e9lien", "initials": "A"}, {"family": "Michot", "given": "Jean-Marie", "initials": "JM"}, {"family": "Fontenay", "given": "Michaela", "initials": "M"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}], "type": "journal article", "published": "2021-03-11", "journal": {"title": "Cell Death Dis", "issn": "2041-4889", "volume": "12", "issue": "3", "pages": "258", "issn-l": null}, "abstract": "The circulating metabolome provides a snapshot of the physiological state of the organism responding to pathogenic challenges. Here we report alterations in the plasma metabolome reflecting the clinical presentation of COVID-19 patients with mild (ambulatory) diseases, moderate disease (radiologically confirmed pneumonitis, hospitalization and oxygen therapy), and critical disease (in intensive care). This analysis revealed major disease- and stage-associated shifts in the metabolome, meaning that at least 77 metabolites including amino acids, lipids, polyamines and sugars, as well as their derivatives, were altered in critical COVID-19 patient's plasma as compared to mild COVID-19 patients. Among a uniformly moderate cohort of patients who received tocilizumab, only 10 metabolites were different among individuals with a favorable evolution as compared to those who required transfer into the intensive care unit. The elevation of one single metabolite, anthranilic acid, had a poor prognostic value, correlating with the maintenance of high interleukin-10 and -18 levels. Given that products of the kynurenine pathway including anthranilic acid have immunosuppressive properties, we speculate on the therapeutic utility to inhibit the rate-limiting enzymes of this pathway including indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase.", "doi": "10.1038/s41419-021-03540-y", "pmid": "33707411", "labels": {"Category: Drug Discovery": null, "Category: Biochemistry": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41419-021-03540-y"}, {"db": "pmc", "key": "PMC7948172"}, {"db": "URL", "key": "https://doi.org/10.1038/s41419-021-03540-y", "description": "All metabolomics data (supplementary tables)"}], "notes": [], "created": "2021-03-17T07:10:40.858Z", "modified": "2021-11-18T13:09:56.552Z"}, {"entity": "publication", "iuid": "910730ae686542e69773578ef3922045", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/910730ae686542e69773578ef3922045.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/910730ae686542e69773578ef3922045"}}, "title": "Interventions for treatment of COVID-19: Second edition of a living systematic review with meta-analyses and trial sequential analyses (The LIVING Project).", "authors": [{"family": "Juul", "given": "Sophie", "initials": "S"}, {"family": "Nielsen", "given": "Emil Eik", "initials": "EE"}, {"family": "Feinberg", "given": "Joshua", "initials": "J"}, {"family": "Siddiqui", "given": "Faiza", "initials": "F"}, {"family": "J\u00f8rgensen", "given": "Caroline Kamp", "initials": "CK"}, {"family": "Barot", "given": "Emily", "initials": "E"}, {"family": "Holgersson", "given": "Johan", "initials": "J"}, {"family": "Nielsen", "given": "Niklas", "initials": "N"}, {"family": "Bentzer", "given": "Peter", "initials": "P"}, {"family": "Veroniki", "given": "Areti Angeliki", "initials": "AA"}, {"family": "Thabane", "given": "Lehana", "initials": "L"}, {"family": "Bu", "given": "Fanlong", "initials": "F"}, {"family": "Klingenberg", "given": "Sarah", "initials": "S"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Jakobsen", "given": "Janus Christian", "initials": "JC"}], "type": "journal article", "published": "2021-03-11", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "3", "pages": "e0248132", "issn-l": "1932-6203"}, "abstract": "COVID-19 is a rapidly spreading disease that has caused extensive burden to individuals, families, countries, and the world. Effective treatments of COVID-19 are urgently needed. This is the second edition of a living systematic review of randomized clinical trials assessing the effects of all treatment interventions for participants in all age groups with COVID-19.\n\nWe planned to conduct aggregate data meta-analyses, trial sequential analyses, network meta-analysis, and individual patient data meta-analyses. Our systematic review was based on PRISMA and Cochrane guidelines, and our eight-step procedure for better validation of clinical significance of meta-analysis results. We performed both fixed-effect and random-effects meta-analyses. Primary outcomes were all-cause mortality and serious adverse events. Secondary outcomes were admission to intensive care, mechanical ventilation, renal replacement therapy, quality of life, and non-serious adverse events. According to the number of outcome comparisons, we adjusted our threshold for significance to p = 0.033. We used GRADE to assess the certainty of evidence. We searched relevant databases and websites for published and unpublished trials until November 2, 2020. Two reviewers independently extracted data and assessed trial methodology. We included 82 randomized clinical trials enrolling a total of 40,249 participants. 81 out of 82 trials were at overall high risk of bias. Meta-analyses showed no evidence of a difference between corticosteroids versus control on all-cause mortality (risk ratio [RR] 0.89; 95% confidence interval [CI] 0.79 to 1.00; p = 0.05; I2 = 23.1%; eight trials; very low certainty), on serious adverse events (RR 0.89; 95% CI 0.80 to 0.99; p = 0.04; I2 = 39.1%; eight trials; very low certainty), and on mechanical ventilation (RR 0.86; 95% CI 0.55 to 1.33; p = 0.49; I2 = 55.3%; two trials; very low certainty). The fixed-effect meta-analyses showed indications of beneficial effects. Trial sequential analyses showed that the required information size for all three analyses was not reached. Meta-analysis (RR 0.93; 95% CI 0.82 to 1.07; p = 0.31; I2 = 0%; four trials; moderate certainty) and trial sequential analysis (boundary for futility crossed) showed that we could reject that remdesivir versus control reduced the risk of death by 20%. Meta-analysis (RR 0.82; 95% CI 0.68 to 1.00; p = 0.05; I2 = 38.9%; four trials; very low certainty) and trial sequential analysis (required information size not reached) showed no evidence of difference between remdesivir versus control on serious adverse events. Fixed-effect meta-analysis showed indications of a beneficial effect of remdesivir on serious adverse events. Meta-analysis (RR 0.40; 95% CI 0.19 to 0.87; p = 0.02; I2 = 0%; two trials; very low certainty) showed evidence of a beneficial effect of intravenous immunoglobulin versus control on all-cause mortality, but trial sequential analysis (required information size not reached) showed that the result was severely underpowered to confirm or reject realistic intervention effects. Meta-analysis (RR 0.63; 95% CI 0.35 to 1.14; p = 0.12; I2 = 77.4%; five trials; very low certainty) and trial sequential analysis (required information size not reached) showed no evidence of a difference between tocilizumab versus control on serious adverse events. Fixed-effect meta-analysis showed indications of a beneficial effect of tocilizumab on serious adverse events. Meta-analysis (RR 0.70; 95% CI 0.51 to 0.96; p = 0.02; I2 = 0%; three trials; very low certainty) showed evidence of a beneficial effect of tocilizumab versus control on mechanical ventilation, but trial sequential analysis (required information size not reached) showed that the result was severely underpowered to confirm of reject realistic intervention effects. Meta-analysis (RR 0.32; 95% CI 0.15 to 0.69; p < 0.00; I2 = 0%; two trials; very low certainty) showed evidence of a beneficial effect of bromhexine versus standard care on non-serious adverse events, but trial sequential analysis (required information size not reached) showed that the result was severely underpowered to confirm or reject realistic intervention effects. Meta-analyses and trial sequential analyses (boundary for futility crossed) showed that we could reject that hydroxychloroquine versus control reduced the risk of death and serious adverse events by 20%. Meta-analyses and trial sequential analyses (boundary for futility crossed) showed that we could reject that lopinavir-ritonavir versus control reduced the risk of death, serious adverse events, and mechanical ventilation by 20%. All remaining outcome comparisons showed that we did not have enough information to confirm or reject realistic intervention effects. Nine single trials showed statistically significant results on our outcomes, but were underpowered to confirm or reject realistic intervention effects. Due to lack of data, it was not relevant to perform network meta-analysis or possible to perform individual patient data meta-analyses.\n\nNo evidence-based treatment for COVID-19 currently exists. Very low certainty evidence indicates that corticosteroids might reduce the risk of death, serious adverse events, and mechanical ventilation; that remdesivir might reduce the risk of serious adverse events; that intravenous immunoglobin might reduce the risk of death and serious adverse events; that tocilizumab might reduce the risk of serious adverse events and mechanical ventilation; and that bromhexine might reduce the risk of non-serious adverse events. More trials with low risks of bias and random errors are urgently needed. This review will continuously inform best practice in treatment and clinical research of COVID-19.\n\nPROSPERO CRD42020178787.", "doi": "10.1371/journal.pone.0248132", "pmid": "33705495", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-38879"}], "notes": [], "created": "2021-03-12T07:06:25.255Z", "modified": "2021-03-12T07:06:25.266Z"}, {"entity": "publication", "iuid": "e4441b5f42514f278ec262f36dd23c9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e4441b5f42514f278ec262f36dd23c9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e4441b5f42514f278ec262f36dd23c9c"}}, "title": "Awake Proning as an Adjunctive Therapy for Refractory Hypoxemia in Non-Intubated Patients with COVID-19 Acute Respiratory Failure: Guidance from an International Group of Healthcare Workers.", "authors": [{"family": "Stilma", "given": "Willemke", "initials": "W"}, {"family": "\u00c5kerman", "given": "Eva", "initials": "E"}, {"family": "Artigas", "given": "Antonio", "initials": "A"}, {"family": "Bentley", "given": "Andrew", "initials": "A"}, {"family": "Bos", "given": "Lieuwe D", "initials": "LD"}, {"family": "Bosman", "given": "Thomas J C", "initials": "TJC"}, {"family": "de Bruin", "given": "Hendrik", "initials": "H"}, {"family": "Brummaier", "given": "Tobias", "initials": "T"}, {"family": "Buiteman-Kruizinga", "given": "Laura A", "initials": "LA"}, {"family": "Carc\u00f2", "given": "Francesco", "initials": "F"}, {"family": "Chesney", "given": "Gregg", "initials": "G"}, {"family": "Chu", "given": "Cindy", "initials": "C"}, {"family": "Dark", "given": "Paul", "initials": "P"}, {"family": "Dondorp", "given": "Arjen M", "initials": "AM"}, {"family": "Gijsbers", "given": "Harm J H", "initials": "HJH"}, {"family": "Gilder", "given": "Mary Ellen", "initials": "ME"}, {"family": "Grieco", "given": "Domenico L", "initials": "DL"}, {"family": "Inglis", "given": "Rebecca", "initials": "R"}, {"family": "Laffey", "given": "John G", "initials": "JG"}, {"family": "Landoni", "given": "Giovanni", "initials": "G"}, {"family": "Lu", "given": "Weihua", "initials": "W"}, {"family": "Maduro", "given": "Lisa M N", "initials": "LMN"}, {"family": "McGready", "given": "Rose", "initials": "R"}, {"family": "McNicholas", "given": "Bairbre", "initials": "B"}, {"family": "de Mendoza", "given": "Diego", "initials": "D"}, {"family": "Morales-Quinteros", "given": "Luis", "initials": "L"}, {"family": "Nosten", "given": "Francois", "initials": "F"}, {"family": "Papali", "given": "Alfred", "initials": "A"}, {"family": "Paternoster", "given": "Gianluca", "initials": "G"}, {"family": "Paulus", "given": "Frederique", "initials": "F"}, {"family": "Pisani", "given": "Luigi", "initials": "L"}, {"family": "Prud'homme", "given": "Eloi", "initials": "E"}, {"family": "Ricard", "given": "Jean-Damien", "initials": "JD"}, {"family": "Roca", "given": "Oriol", "initials": "O"}, {"family": "Sartini", "given": "Chiara", "initials": "C"}, {"family": "Scaravilli", "given": "Vittorio", "initials": "V"}, {"family": "Schultz", "given": "Marcus J", "initials": "MJ"}, {"family": "Sivakorn", "given": "Chaisith", "initials": "C"}, {"family": "Spronk", "given": "Peter E", "initials": "PE"}, {"family": "Sztajnbok", "given": "Jaques", "initials": "J"}, {"family": "Trigui", "given": "Youssef", "initials": "Y"}, {"family": "Vollman", "given": "Kathleen M", "initials": "KM"}, {"family": "van der Woude", "given": "Margaretha C E", "initials": "MCE"}], "type": "journal article", "published": "2021-03-11", "journal": {"title": "Am J Trop Med Hyg", "issn": "1476-1645", "volume": null, "issue": null, "issn-l": "0002-9637"}, "abstract": "Non-intubated patients with acute respiratory failure due to COVID-19 could benefit from awake proning. Awake proning is an attractive intervention in settings with limited resources, as it comes with no additional costs. However, awake proning remains poorly used probably because of unfamiliarity and uncertainties regarding potential benefits and practical application. To summarize evidence for benefit and to develop a set of pragmatic recommendations for awake proning in patients with COVID-19 pneumonia, focusing on settings where resources are limited, international healthcare professionals from high and low- and middle-income countries (LMICs) with known expertise in awake proning were invited to contribute expert advice. A growing number of observational studies describe the effects of awake proning in patients with COVID-19 pneumonia in whom hypoxemia is refractory to simple measures of supplementary oxygen. Awake proning improves oxygenation in most patients, usually within minutes, and reduces dyspnea and work of breathing. The effects are maintained for up to 1 hour after turning back to supine, and mostly disappear after 6-12 hours. In available studies, awake proning was not associated with a reduction in the rate of intubation for invasive ventilation. Awake proning comes with little complications if properly implemented and monitored. Pragmatic recommendations including indications and contraindications were formulated and adjusted for resource-limited settings. Awake proning, an adjunctive treatment for hypoxemia refractory to supplemental oxygen, seems safe in non-intubated patients with COVID-19 acute respiratory failure. We provide pragmatic recommendations including indications and contraindications for the use of awake proning in LMICs.", "doi": "10.4269/ajtmh.20-1445", "pmid": "33705348", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "tpmd201445"}, {"db": "pmc", "key": "PMC8103477"}], "notes": [], "created": "2021-03-12T07:05:39.237Z", "modified": "2021-11-18T12:57:03.738Z"}, {"entity": "publication", "iuid": "02ac2f6d92cb43919788a8738c0d2c7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02ac2f6d92cb43919788a8738c0d2c7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02ac2f6d92cb43919788a8738c0d2c7a"}}, "title": "Analysis of the early COVID-19 epidemic curve in Germany by regression models with change points.", "authors": [{"family": "K\u00fcchenhoff", "given": "Helmut", "initials": "H"}, {"family": "G\u00fcnther", "given": "Felix", "initials": "F"}, {"family": "H\u00f6hle", "given": "Michael", "initials": "M"}, {"family": "Bender", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2021-03-11", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "issn-l": null, "volume": null, "issue": null, "pages": "1-17"}, "abstract": null, "doi": "10.1017/S0950268821000558", "pmid": "33691815", "labels": {"Category: Public Health": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0950268821000558"}], "notes": [], "created": "2021-03-12T06:11:13.310Z", "modified": "2021-06-18T15:03:05.817Z"}, {"entity": "publication", "iuid": "506375d9c20e4838a66749414bb9fd7f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/506375d9c20e4838a66749414bb9fd7f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/506375d9c20e4838a66749414bb9fd7f"}}, "title": "Dangerous liaisons: an online experiment on the role of scientific experts and politicians in ensuring public support for anti-COVID measures.", "authors": [{"family": "Farjam", "given": "Mike", "initials": "M"}, {"family": "Bianchi", "given": "Federico", "initials": "F"}, {"family": "Squazzoni", "given": "Flaminio", "initials": "F"}, {"family": "Bravo", "given": "Giangiacomo", "initials": "G"}], "type": "journal article", "published": "2021-03-10", "journal": {"title": "R Soc Open Sci", "issn": "2054-5703", "volume": "8", "issue": "3", "pages": "201310", "issn-l": null}, "abstract": "The effectiveness of public health measures to prevent COVID-19 contagion has required less vulnerable citizens to pay an individual cost in terms of personal liberty infringement to protect more vulnerable groups. However, the close relationship between scientific experts and politicians in providing information on COVID-19 measures makes it difficult to understand which communication source was more effective in increasing pro-social behaviour. Here, we present an online experiment performed in May 2020, during the first wave of the pandemic on 1131 adult residents in Lombardy, Italy, one of the world's hardest hit regions. Results showed that when scientific experts recommended anti-contagion measures, participants were more sensitive to pro-social motivations, unlike whenever these measures were recommended by politicians and scientific experts together. Our findings suggest the importance of trusted sources in public communication during a pandemic.", "doi": "10.1098/rsos.201310", "pmid": "33959315", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "rsos201310"}, {"db": "pmc", "key": "PMC8074882"}], "notes": [], "created": "2021-05-17T19:07:13.485Z", "modified": "2021-05-17T19:07:13.496Z"}, {"entity": "publication", "iuid": "7eb3ba1ca5864d3e8b7a01c85b5ca3ac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7eb3ba1ca5864d3e8b7a01c85b5ca3ac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7eb3ba1ca5864d3e8b7a01c85b5ca3ac"}}, "title": "COVID-19 Antibody Testing of Patients Admitted to the ICU by a Novel, Point-of-Care Assay, and the Relationship to Survival", "authors": [{"family": "Casswell", "given": "Stacey", "initials": "S"}, {"family": "Eriksson", "given": "Ann Katrin", "initials": "AK"}, {"family": "Moberg", "given": "Lena", "initials": "L"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Marshall", "given": "Fiona", "initials": "F"}, {"family": "Venge", "given": "Per", "initials": "P"}], "type": "posted-content", "published": "2021-03-10", "journal": {"title": "Research Square", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Diagnosing persons infected by COVID-19 is key to the control of the pandemic. It has, however, become increasingly important to identify those who have had the infection by measurement of circulating antibodies against Sars-COV-2 of the IgM and IgG type. In this report we show the development of a rapid and sensitive point-of-care assay for the measurement of IgG antibodies against the two spike proteins, S1 and S2, of the Sars-COV-2 virus.\r\nMethod\r\nThe AgPlus electrochemical technology was applied and the S1 and S2 proteins were biotinylated and immobilized onto streptavidin coated magnetic particles as the capture component of the assay. The IgG antibodies bound to the particles were detected by anti-human IgG and the signal expressed as nC (nano Coulomb). Assay time was <10 min.\r\nResults\r\nPlasma (n=211) from 117 SARS-Cov-2 PCR positive patients and from 78 persons with samples taken before the COVID-19 pandemic were analysed. The sensitivity and specificity of the assay were 91.9% and 100%, respectively. The assay was highly correlated to a predicate and FDA-approved IgG antibody ELISA (r=0.81). The IgG response was significantly lower in patients who died during their ICU stay.\r\nConclusions\r\nA poor IgG response after a COVID-19 infection is a serious risk factor as to death. A sensitive, rapid and accurate IgG antibody POC assay should be useful in the daily management and evaluation of COVID-19 infected patients.", "doi": "10.21203/rs.3.rs-289303/v1", "pmid": null, "labels": {"Category: Proteins": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Research Area: Biobanks for COVID-19 research": null, "Type: Preprint": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT04316884", "description": null}], "notes": [], "created": "2021-03-16T07:15:17.244Z", "modified": "2021-05-06T05:38:49.997Z"}, {"entity": "publication", "iuid": "dda2feafd8ce45c5b77c4b517d6b0d07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dda2feafd8ce45c5b77c4b517d6b0d07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dda2feafd8ce45c5b77c4b517d6b0d07"}}, "title": "Recommendations for the use of COVID-19 vaccines in patients with immune-mediated kidney diseases.", "authors": [{"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Anders", "given": "Hans-Joachim", "initials": "HJ"}, {"family": "Fernandez-Ju\u00e1rez", "given": "Gema Maria", "initials": "GM"}, {"family": "Floege", "given": "J\u00fcrgen", "initials": "J"}, {"family": "Goumenos", "given": "Dimitrios", "initials": "D"}, {"family": "Segelmark", "given": "M\u00e5rten", "initials": "M"}, {"family": "Tesar", "given": "Vladimir", "initials": "V"}, {"family": "Turkmen", "given": "Kultigin", "initials": "K"}, {"family": "van Kooten", "given": "Cees", "initials": "C"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Immunonephrology Working Group of the ERA-EDTA (European Renal Association \u2013 European Dialysis, Transplant Association)", "given": "", "initials": ""}], "type": "journal article", "published": "2021-03-09", "journal": {"title": "Nephrol Dial Transplant", "issn": "1460-2385", "volume": null, "issue": null, "issn-l": "0931-0509"}, "abstract": "Coronavirus Disease 19 (COVID-19) vaccine platforms are becoming available and are the most promising strategy to curb the spread of SARS-CoV-2 infections. However, numerous uncertainties exist regarding the pros and cons of vaccination, especially in patients with (immune-mediated) kidney diseases on immunosuppressive drugs. Here, members of the Immunonephrology Working Group (IWG) of the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) discuss thirteen frequently-asked questions regarding safety and efficacy of the most promising vaccine candidates. Post-marketing surveillance should be performed to estimate the rate of vaccine response (humoral and cellular) of different vaccine platforms, and surveillance of disease activity following administration of COVID-19 vaccines. Some of the candidates induce signaling pathways which also promote autoimmune kidney diseases, e.g. type I interferons in systemic lupus erythematosus. Efficacy estimates would thus far favor the use of selected COVID-19 vaccines, such as BNT162b2, mRNA-1273 or Gam-COVID-Vac. Humoral immune response after vaccination should be monitored using appropriate assays. Even in the absence of neutralizing antibodies patients might be protected by a sufficient cellular immune response capable to reduce severity of COVID-19. A reduced vaccine response after the use of CD20-depleting agents is anticipated, and it is particularly important to discuss strategies to improve vaccine response with these patients. Distancing and shielding measures remain important as not all vaccines fully protect from coronavirus infection. In-depth information about the most pressing vaccine questions is essential to reduce vaccine hesitancy of patients.", "doi": "10.1093/ndt/gfab064", "pmid": "33693778", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "6163301"}, {"db": "pmc", "key": "PMC7989374"}], "notes": [], "created": "2021-03-12T06:41:55.287Z", "modified": "2021-11-18T12:53:07.877Z"}, {"entity": "publication", "iuid": "65b3cf84cf1c4adabcf5084d92f886fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65b3cf84cf1c4adabcf5084d92f886fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65b3cf84cf1c4adabcf5084d92f886fd"}}, "title": "Association between SARS-CoV-2 and exposure risks in health care workers and university employees - a cross-sectional study.", "authors": [{"family": "Nygren", "given": "David", "initials": "D"}, {"family": "Nor\u00e9n", "given": "Jonas", "initials": "J"}, {"family": "De Marinis", "given": "Yang", "initials": "Y"}, {"family": "Holmberg", "given": "Anna", "initials": "A"}, {"family": "Fraenkel", "given": "Carl-Johan", "initials": "C"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-03-09", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "issn-l": "2374-4235", "volume": null, "issue": null, "pages": "1-9"}, "abstract": "In health care workers SARS-CoV-2 has been shown to be an occupational health risk, often associated with transmission between health care workers. Yet, insufficient information on transmission dynamics has been presented to elucidate the precise risk factors for contracting SARS-CoV-2 in this group.\r\n\r\nIn this cross-sectional study, we investigated association between questionnaire answers on potential exposure situations and SARS-CoV-2-positivity. Health care workers with and without COVID-19-patient contact at nine units at Sk\u00e5ne University Hospitals in Malm\u00f6 and Lund, Sweden and university employees from Lund University, Sweden were enrolled. To limit impact of health care worker to health care worker transmission, units with known outbreaks were excluded. A SARS-CoV-2-positive case was defined by a previous positive PCR or anti-SARS-CoV-2 IgG in the ZetaGene COVID-19 Antibody Test.\r\n\r\nSARS-CoV-2-positivity was detected in 11/51 (22%) health care workers in COVID-19-units, 10/220 (5%) in non-COVID-19-units and 11/192 (6%) University employees ( p = .001, Fischer's exact). In health care workers, SARS-CoV-2-positivity was associated with work in a designated COVID-19-unit (OR 5.7 (95CI 2.1-16)) and caring for COVID-19-patients during the majority of shifts (OR 5.4 (95CI 2.0-15)). In all participants, SARS-CoV-2-positivity was associated with a confirmed COVID-19 case (OR 10 (95CI 2.0-45)) in the household.\r\n\r\nOur study confirmed previous findings of elevated risk of acquiring SARS-CoV-2 in health care workers in COVID-19-units, despite exclusion of units with known outbreaks. Interestingly, health care workers in non-COVID-19-units had similar risk as University employees. Further measures to improve the safety of health care workers might be needed.KEY POINTSPrevious findings of elevated risk of contracting SARS-CoV-2 in health care workers with COVID-19 patient contact was confirmed, despite exclusion of wards with known SARS-CoV-2 outbreaks. Further measures to improve the safety of health care workers might be needed.", "doi": "10.1080/23744235.2021.1892819", "pmid": "33689558", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-12T06:06:56.943Z", "modified": "2021-06-18T14:49:02.100Z"}, {"entity": "publication", "iuid": "df4389825bde4d01ad2e227a293a4a1b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/df4389825bde4d01ad2e227a293a4a1b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/df4389825bde4d01ad2e227a293a4a1b"}}, "title": "Assessing relative COVID-19 mortality: a Swiss population-based study.", "authors": [{"family": "Hothorn", "given": "Torsten", "initials": "T"}, {"family": "Bopp", "given": "Matthias", "initials": "M"}, {"family": "G\u00fcnthard", "given": "Huldrych", "initials": "H"}, {"family": "Keiser", "given": "Olivia", "initials": "O"}, {"family": "Roelens", "given": "Maroussia", "initials": "M"}, {"family": "Weibull", "given": "Caroline E", "initials": "CE"}, {"family": "Crowther", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2021-03-08", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "11", "issue": "3", "pages": "e042387", "issn-l": "2044-6055"}, "abstract": "Severity of the COVID-19 has been previously reported in terms of absolute mortality in SARS-CoV-2 positive cohorts. An assessment of mortality relative to mortality in the general population is presented.\n\nRetrospective population-based study.\n\nIndividual information on symptomatic confirmed SARS-CoV-2 patients and subsequent deaths from any cause were compared with the all-cause mortality in the Swiss population of 2018. Starting 23 February 2020, mortality in COVID-19 patients was monitored for 80 days and compared with the population mortality observed in the same time of year starting 23 February 2018.\n\n5 102 300 inhabitants of Switzerland aged 35-95 without COVID-19 (general population in spring 2018) and 20 769 persons tested positively for COVID-19 during the first wave in spring 2020.\n\nSex-specific and age-specific mortality rates were estimated using Cox proportional hazards models. Absolute probabilities of death were predicted and risk was assessed in terms of relative mortality by taking the ratio between the sex-specific and age-specific absolute mortality in COVID-19 patients and the corresponding mortality in the 2018 general population.\n\nAbsolute mortalities increased with age and were higher for males compared with females, both in the general population and in positively tested persons. A confirmed SARS-CoV-2 infection substantially increased the probability of death across all patient groups at least eightfold. The highest relative mortality risks were observed among males and younger patients. Male COVID-19 patients exceeded the population hazard for males (HR 1.21, 95% CI 1.02 to 1.44). An additional year of age increased the population hazard in COVID-19 patients only marginally (HR 1.00, 95% CI 1.00 to 1.01).\n\nHealthcare professionals, decision-makers and societies are provided with an additional population-adjusted assessment of COVID-19 mortality risk. In combination with absolute measures of risk, the relative risks presented here help to develop a more comprehensive understanding of the actual impact of COVID-19.", "doi": "10.1136/bmjopen-2020-042387", "pmid": "34006026", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-042387"}, {"db": "URL", "key": "https://gitlab.switch.ch/torsten.hothorn/relative_covid-19_mortality", "description": "Data, R and Stata code"}], "notes": [], "created": "2021-05-20T14:50:19.838Z", "modified": "2021-11-19T11:39:40.055Z"}, {"entity": "publication", "iuid": "abdd36ff54f448bb8c50ab2769484a66", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abdd36ff54f448bb8c50ab2769484a66.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abdd36ff54f448bb8c50ab2769484a66"}}, "title": "Digital health and COVID-19: challenges of use and implementation in sub-Saharan Africa.", "authors": [{"family": "Mogessie", "given": "Yidnekachew Girma", "initials": "YG"}, {"family": "Ntacyabukura", "given": "Blaise", "initials": "B"}, {"family": "Mengesha", "given": "Dawit Tesfagiorgis", "initials": "DT"}, {"family": "Musa", "given": "Mohamed Babiker", "initials": "MB"}, {"family": "Wangari", "given": "Marie-Claire", "initials": "MC"}, {"family": "Claude", "given": "Nsabimana", "initials": "N"}, {"family": "Buntongyi", "given": "Nit", "initials": "N"}, {"family": "Lucero-Prisno", "given": "Don Eliseo", "initials": "DE"}], "type": "journal article", "published": "2021-03-07", "journal": {"title": "Pan Afr Med J", "issn": "1937-8688", "volume": "38", "issue": null, "pages": "240", "issn-l": null}, "abstract": "COVID-19 is a global health emergency that exposed the gaps in health systems globally, especially in sub-Saharan Africa home to many fragile healthcare systems and a region beset with a large burden of disease. Various mitigation strategies have been put in place to stop the spread of COVID-19 and management of patients in sub-Saharan Africa. However, much still need to be done. Digital health provides the promise for the continent to bridge the gap in decreasing the negative impact of COVID-19 and effectively mitigate the pandemic. This commentary argues how countries in sub-Saharan Africa need to embrace the use of digital health in public health interventions to vigorously mitigate the COVID-19 pandemic and to contribute towards attaining universal health coverage (UHC).", "doi": "10.11604/pamj.2021.38.240.27948", "pmid": "34046143", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PAMJ-38-240"}, {"db": "pmc", "key": "PMC8140728"}], "notes": [], "created": "2021-05-29T15:23:16.329Z", "modified": "2021-05-29T16:28:47.779Z"}, {"entity": "publication", "iuid": "9e8e161c43634d88b5d5a60fdaa4cbd5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9e8e161c43634d88b5d5a60fdaa4cbd5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9e8e161c43634d88b5d5a60fdaa4cbd5"}}, "title": "Understanding COVID-19 through adverse outcome pathways - 2nd CIAO AOP Design Workshop.", "authors": [{"family": "Wittwehr", "given": "Clemens", "initials": "C"}, {"family": "Amorim", "given": "Maria Jo\u00e3o", "initials": "MJ"}, {"family": "Clerbaux", "given": "Laure-Alix", "initials": "LA"}, {"family": "Krebs", "given": "Catharine", "initials": "C"}, {"family": "Landesmann", "given": "Brigitte", "initials": "B"}, {"family": "Macmillan", "given": "Donna", "initials": "D"}, {"family": "Nymark", "given": "Penny", "initials": "P"}, {"family": "Ram", "given": "Rebecca", "initials": "R"}, {"family": "Garcia-Reyero", "given": "Nat\u00e0lia", "initials": "N"}, {"family": "Sachana", "given": "Magdalini", "initials": "M"}, {"family": "Sullivan", "given": "Kristie", "initials": "K"}, {"family": "Sund", "given": "Jukka", "initials": "J"}, {"family": "Willett", "given": "Catharine", "initials": "C"}], "type": "editorial", "published": "2021-03-05", "journal": {"title": "ALTEX", "issn": "1868-596X", "volume": null, "issue": null, "issn-l": null}, "abstract": "The CIAO project (Modelling the Pathogenesis of COVID\u201119 using the Adverse Outcome Pathway framework) aims at a holistic assembly of knowledge to deliver a truly transdisciplinary description of the entire COVID\u201119 physiopathology starting with the initial contact with the SARS\u2011CoV\u201119 virus and ending with one or several adverse outcomes, e.g., respiratory failure. On 27\u201128 January 2021, a group of 50+ scientists from numerous organizations around the world met in the 2nd CIAO AOP Design Workshop to discuss the depiction of the COVID\u201119 disease process as a series of key events (KEs) in a network of AOPs. During the workshop, 74 such KEs forming 13 AOPs were identified, covering COVID\u201119 manifestations that affect the respiratory, neurological, liver, cardiovascular, kidney and gastrointestinal systems. Modulating factors influencing the course and severity of the disease were also addressed, as was a possible extension of the investigations beyond purely biological phenomena. The workshop ended with the creation of seven working groups, which will further elaborate on the AOPs to be presented and discussed in the 3rd CIAO workshop on 28-29 April 2021.", "doi": "10.14573/altex.2102221", "pmid": "33677612", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-03-09T06:27:27.194Z", "modified": "2021-03-09T06:28:05.358Z"}, {"entity": "publication", "iuid": "ef735d339af4451b8855e6175b157d6b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef735d339af4451b8855e6175b157d6b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef735d339af4451b8855e6175b157d6b"}}, "title": "The emergence and ongoing convergent evolution of the N501Y lineages coincides with a major global shift in the SARS-CoV-2 selective landscape", "authors": [{"family": "Martin", "given": "Darren P", "initials": "DP"}, {"family": "Weaver", "given": "Steven", "initials": "S"}, {"family": "Tegally", "given": "Houryiah", "initials": "H"}, {"family": "San", "given": "Emmanuel James", "initials": "EJ"}, {"family": "Shank", "given": "Stephen D", "initials": "SD"}, {"family": "Wilkinson", "given": "Eduan", "initials": "E"}, {"family": "Giandhari", "given": "Jennifer", "initials": "J"}, {"family": "Naidoo", "given": "Sureshnee", "initials": "S"}, {"family": "Pillay", "given": "Yeshnee", "initials": "Y"}, {"family": "Singh", "given": "Lavanya", "initials": "L"}, {"family": "Lessells", "given": "Richard J", "initials": "RJ"}, {"family": "Gupta", "given": "Ravindra K", "initials": "RK"}, {"family": "Wertheim", "given": "Joel O", "initials": "JO"}, {"family": "Nekturenko", "given": "Anton", "initials": "A"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Harkins", "given": "Gordon W", "initials": "GW"}, {"family": "Lemey", "given": "Philippe", "initials": "P"}, {"family": "MacLean", "given": "Oscar A", "initials": "OA"}, {"family": "Robertson", "given": "David L", "initials": "DL"}, {"family": "de Oliveira", "given": "Tulio", "initials": "T"}, {"family": "Pond", "given": "Sergei L Kosakovsky", "initials": "SLK"}, {"family": "None", "given": "", "initials": ""}, {"family": "None", "given": "", "initials": ""}], "type": "posted-content", "published": "2021-03-05", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "6", "doi": "10.1101/2021.02.23.21252268", "pmid": null, "labels": {"Funder: H2020": null, "Category: Genomics & transcriptomics": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-06-10T03:49:19.420Z", "modified": "2021-06-18T09:11:11.931Z"}, {"entity": "publication", "iuid": "9e297cf816a3407886213128451b438e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9e297cf816a3407886213128451b438e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9e297cf816a3407886213128451b438e"}}, "title": "Point-of-care bulk testing for SARS-CoV-2 by combining hybridization capture with improved colorimetric LAMP.", "authors": [{"family": "Bokelmann", "given": "Lukas", "initials": "L"}, {"family": "Nickel", "given": "Olaf", "initials": "O"}, {"family": "Maricic", "given": "Tomislav", "initials": "T"}, {"family": "P\u00e4\u00e4bo", "given": "Svante", "initials": "S"}, {"family": "Meyer", "given": "Matthias", "initials": "M"}, {"family": "Borte", "given": "Stephan", "initials": "S"}, {"family": "Riesenberg", "given": "Stephan", "initials": "S"}], "type": "journal article", "published": "2021-03-05", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "1467", "issn-l": "2041-1723"}, "abstract": "Efforts to contain the spread of SARS-CoV-2 have spurred the need for reliable, rapid, and cost-effective diagnostic methods which can be applied to large numbers of people. However, current standard protocols for the detection of viral nucleic acids while sensitive, require a high level of automation and sophisticated laboratory equipment to achieve throughputs that allow whole communities to be tested on a regular basis. Here we present Cap-iLAMP (capture and improved loop-mediated isothermal amplification) which combines a hybridization capture-based RNA extraction of gargle lavage samples with an improved colorimetric RT-LAMP assay and smartphone-based color scoring. Cap-iLAMP is compatible with point-of-care testing and enables the detection of SARS-CoV-2 positive samples in less than one hour. In contrast to direct addition of the sample to improved LAMP (iLAMP), Cap-iLAMP prevents false positives and allows single positive samples to be detected in pools of 25 negative samples, reducing the reagent cost per test to ~1 Euro per individual.", "doi": "10.1038/s41467-021-21627-0", "pmid": "33674580", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-21627-0"}], "notes": [], "created": "2021-03-08T10:52:35.942Z", "modified": "2021-03-08T10:57:30.916Z"}, {"entity": "publication", "iuid": "78f0928173d44035925dab2beb610117", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/78f0928173d44035925dab2beb610117.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/78f0928173d44035925dab2beb610117"}}, "title": "No findings of SARS-CoV-2 in conjunctival swabs from patients at an emergency outpatient ophthalmological healthcare facility in a Swedish county hospital: a cross-sectional study.", "authors": [{"family": "Granstam", "given": "Elisabet", "initials": "E"}, {"family": "Krifors", "given": "Anders", "initials": "A"}, {"family": "Freyhult", "given": "Elisabeth", "initials": "E"}, {"family": "\u00c5kerblom", "given": "Hanna", "initials": "H"}], "type": "journal article", "published": "2021-03-05", "journal": {"title": "BMJ Open Ophthalmol", "issn": "2397-3269", "volume": "6", "issue": "1", "pages": "e000616", "issn-l": null}, "abstract": "COVID-19 is caused by SARS-CoV-2. Virus has been found in conjunctiva of hospitalised patients with COVID-19. Conjunctivitis has also been reported as a presenting symptom of disease.\n\nThe aims of the study were to investigate the prevalence of SARS-CoV-2 in the conjunctiva and throat among patients presenting at the emergency outpatient ophthalmological healthcare facility at a county hospital along with investigating the seroprevalence of SARS-CoV-2 among staff at the department.\n\nSwabs from conjunctiva and throat of patients were analysed with real-time reverse transcriptase PCR (RT-PCR) for SARS-CoV-2. Blood samples for serological analysis were obtained from staff. A questionnaire was used to investigate symptoms associated with COVID-19 during the last 3 months as well as symptoms for which the patients were seeking ophthalmological healthcare.\n\nIn total, 68 patients and 70 individuals from the staff were included in the study. Conjunctivitis was observed in 7% of patients. One patient, presenting with reduced visual acuity due to preretinal haemorrhage in the macula, was positive for SARS-CoV-2 in throat swab. Contact tracing was negative. All other RT-PCR tests were negative. Seropositivity for SARS-CoV-2 was found in 4% of staff.\n\nOur study demonstrated low prevalence of SARS-CoV-2 among patients as well as low seroprevalence of SARS-CoV-2 IgG-antibodies among staff at the ophthalmological ward. The risk for contracting COVID-19 at the department was small. Follow-up investigation is planned.", "doi": "10.1136/bmjophth-2020-000616", "pmid": "34041362", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjophth-2020-000616"}, {"db": "pmc", "key": "PMC7938470"}], "notes": [], "created": "2021-05-29T15:28:44.179Z", "modified": "2021-05-29T15:28:44.201Z"}, {"entity": "publication", "iuid": "3cee578a4158419fa545d7efe3fd8b58", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3cee578a4158419fa545d7efe3fd8b58.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3cee578a4158419fa545d7efe3fd8b58"}}, "title": "Burden of Disease Methods: A Guide to Calculate COVID-19 Disability-Adjusted Life Years.", "authors": [{"family": "Wyper", "given": "Grant M A", "initials": "GMA"}, {"family": "Assun\u00e7\u00e3o", "given": "Ricardo M A", "initials": "RMA"}, {"family": "Colzani", "given": "Edoardo", "initials": "E"}, {"family": "Grant", "given": "Ian", "initials": "I"}, {"family": "Haagsma", "given": "Juanita A", "initials": "JA"}, {"family": "Lagerweij", "given": "Giske", "initials": "G"}, {"family": "Von der Lippe", "given": "Elena", "initials": "E"}, {"family": "McDonald", "given": "Scott A", "initials": "SA"}, {"family": "Pires", "given": "Sara M", "initials": "SM"}, {"family": "Porst", "given": "Michael", "initials": "M"}, {"family": "Speybroeck", "given": "Niko", "initials": "N"}, {"family": "Devleesschauwer", "given": "Brecht", "initials": "B"}], "type": "journal article", "published": "2021-03-05", "journal": {"title": "Int J Public Health", "issn": "1661-8564", "volume": "66", "pages": "619011", "issn-l": null}, "abstract": null, "doi": "10.3389/ijph.2021.619011", "pmid": "34744580", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "619011"}, {"db": "pmc", "key": "PMC8565264"}], "notes": [], "created": "2021-11-26T15:35:22.656Z", "modified": "2021-11-26T15:35:22.669Z"}, {"entity": "publication", "iuid": "a044efb1677249b29be6bbb0a662f825", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a044efb1677249b29be6bbb0a662f825.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a044efb1677249b29be6bbb0a662f825"}}, "title": "A chronicle of SARS-CoV-2: Seasonality, environmental fate, transport, inactivation, and antiviral drug resistance.", "authors": [{"family": "Kumar", "given": "Manish", "initials": "M"}, {"family": "Mazumder", "given": "Payal", "initials": "P"}, {"family": "Mohapatra", "given": "Sanjeeb", "initials": "S"}, {"family": "Kumar Thakur", "given": "Alok", "initials": "A"}, {"family": "Dhangar", "given": "Kiran", "initials": "K"}, {"family": "Taki", "given": "Kaling", "initials": "K"}, {"family": "Mukherjee", "given": "Santanu", "initials": "S"}, {"family": "Kumar Patel", "given": "Arbind", "initials": "A"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Mohapatra", "given": "Pranab", "initials": "P"}, {"family": "Rinklebe", "given": "J\u00f6rg", "initials": "J"}, {"family": "Kitajima", "given": "Masaaki", "initials": "M"}, {"family": "Hai", "given": "Faisal I", "initials": "FI"}, {"family": "Khursheed", "given": "Anwar", "initials": "A"}, {"family": "Furumai", "given": "Hiroaki", "initials": "H"}, {"family": "Sonne", "given": "Christian", "initials": "C"}, {"family": "Kuroda", "given": "Keisuke", "initials": "K"}], "type": "journal article", "published": "2021-03-05", "journal": {"title": "J Hazard Mater", "issn": "1873-3336", "volume": "405", "issue": null, "pages": "124043", "issn-l": null}, "abstract": "In this review, we present the environmental perspectives of the viruses and antiviral drugs related to SARS-CoV-2. The present review paper discusses occurrence, fate, transport, susceptibility, and inactivation mechanisms of viruses in the environment as well as environmental occurrence and fate of antiviral drugs, and prospects (prevalence and occurrence) of antiviral drug resistance (both antiviral drug resistant viruses and antiviral resistance in the human). During winter, the number of viral disease cases and environmental occurrence of antiviral drug surge due to various biotic and abiotic factors such as transmission pathways, human behaviour, susceptibility, and immunity as well as cold climatic conditions. Adsorption and persistence critically determine the fate and transport of viruses in the environment. Inactivation and disinfection of virus include UV, alcohol, and other chemical-base methods but the susceptibility of virus against these methods varies. Wastewater treatment plants (WWTPs) are major reserviors of antiviral drugs and their metabolites and transformation products. Ecotoxicity of antiviral drug residues against aquatic organisms have been reported, however more threatening is the development of antiviral resistance, both in humans and in wild animal reservoirs. In particular, emergence of antiviral drug-resistant viruses via exposure of wild animals to high loads of antiviral residues during the current pandemic needs further evaluation.", "doi": "10.1016/j.jhazmat.2020.124043", "pmid": "33268203", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0304-3894(20)32033-1"}, {"db": "pmc", "key": "PMC7536132"}], "notes": [], "created": "2021-02-10T18:52:29.712Z", "modified": "2021-02-10T18:53:14.080Z"}, {"entity": "publication", "iuid": "2df5739354b6453abf381a53d3a6c530", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2df5739354b6453abf381a53d3a6c530.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2df5739354b6453abf381a53d3a6c530"}}, "title": "OmicLoupe: facilitating biological discovery by interactive exploration of multiple omic datasets and statistical comparisons.", "authors": [{"family": "Willforss", "given": "Jakob", "initials": "J"}, {"family": "Siino", "given": "Valentina", "initials": "V"}, {"family": "Levander", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2021-03-04", "journal": {"title": "BMC Bioinformatics", "issn": "1471-2105", "volume": "22", "issue": "1", "pages": "107", "issn-l": null}, "abstract": "Visual exploration of gene product behavior across multiple omic datasets can pinpoint technical limitations in data and reveal biological trends. Still, such exploration is challenging as there is a need for visualizations that are tailored for the purpose.\n\nThe OmicLoupe software was developed to facilitate visual data exploration and provides more than 15 interactive cross-dataset visualizations for omics data. It expands visualizations to multiple datasets for quality control, statistical comparisons and overlap and correlation analyses, while allowing for rapid inspection and downloading of selected features. The usage of OmicLoupe is demonstrated in three different studies, where it allowed for detection of both technical data limitations and biological trends across different omic layers. An example is an analysis of SARS-CoV-2 infection based on two previously published studies, where OmicLoupe facilitated the identification of gene products with consistent expression changes across datasets at both the transcript and protein levels.\n\nOmicLoupe provides fast exploration of omics data with tailored visualizations for comparisons within and across data layers. The interactive visualizations are highly informative and are expected to be useful in various analyses of both newly generated and previously published data. OmicLoupe is available at quantitativeproteomics.org/omicloupe.", "doi": "10.1186/s12859-021-04043-5", "pmid": "33663372", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12859-021-04043-5"}], "notes": [], "created": "2021-03-06T10:15:06.148Z", "modified": "2021-03-06T10:15:06.170Z"}, {"entity": "publication", "iuid": "e52c4079071d410b99cb020629c9705c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e52c4079071d410b99cb020629c9705c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e52c4079071d410b99cb020629c9705c"}}, "title": "Antibodies to SARS-CoV-2 and risk of past or future sick leave.", "authors": [{"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Elfstr\u00f6m", "given": "K Miriam", "initials": "KM"}, {"family": "Blomqvist", "given": "Jonas", "initials": "J"}, {"family": "Eklund", "given": "Carina", "initials": "C"}, {"family": "Lagheden", "given": "Camilla", "initials": "C"}, {"family": "Nordqvist-Kleppe", "given": "Sara", "initials": "S"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Olofsson", "given": "Jennie", "initials": "J"}, {"family": "Andersson", "given": "Eni", "initials": "E"}, {"family": "Jernbom Falk", "given": "August", "initials": "A"}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S"}, {"family": "Hultin", "given": "Emilie", "initials": "E"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Mattsson", "given": "Johan", "initials": "J"}, {"family": "M\u00fchr", "given": "Laila Sara Arroyo", "initials": "LSA"}, {"family": "Conneryd Lundgren", "given": "Kalle", "initials": "K"}], "type": "journal article", "published": "2021-03-04", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "5160"}, "abstract": "The extent that antibodies to SARS-CoV-2 may protect against future virus-associated disease is unknown. We invited all employees (n = 15,300) at work at the Karolinska University Hospital, Stockholm, Sweden to participate in a study examining SARS-Cov-2 antibodies in relation to registered sick leave. For consenting 12,928 healthy hospital employees antibodies to SARS-CoV-2 could be determined and compared to participant sick leave records. Subjects with viral serum antibodies were not at excess risk for future sick leave (adjusted odds ratio (OR) controlling for age and sex: 0.85 [95% confidence interval (CI) (0.85 (0.43-1.68)]. By contrast, subjects with antibodies had an excess risk for sick leave in the weeks prior to testing [adjusted OR in multivariate analysis: 3.34 (2.98-3.74)]. Thus, presence of viral antibodies marks past disease and protection against excess risk of future disease. Knowledge of whether exposed subjects have had disease in the past or are at risk for future disease is essential for planning of control measures.Trial registration: First registered on 02/06/20, ClinicalTrials.gov NCT04411576.", "doi": "10.1038/s41598-021-84356-w", "pmid": "33664279", "labels": {"Category: Health": null, "Category: Proteins": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Research Area: High-throughput and high-content serology": null}, "xrefs": [{"db": "pmc", "key": "PMC7933367"}, {"db": "pii", "key": "10.1038/s41598-021-84356-w"}, {"db": "ClinicalTrials.gov", "key": "NCT04411576"}], "notes": [], "created": "2021-03-06T10:13:45.982Z", "modified": "2023-06-19T14:23:55.553Z"}, {"entity": "publication", "iuid": "66c7514e2642441da18b49f672fd2839", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66c7514e2642441da18b49f672fd2839.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66c7514e2642441da18b49f672fd2839"}}, "title": "Seroprevalence of coronavirus disease 2019 (COVID-19) among health care workers from three pandemic hospitals of Turkey.", "authors": [{"family": "Alkurt", "given": "Gizem", "initials": "G"}, {"family": "Murt", "given": "Ahmet", "initials": "A"}, {"family": "Aydin", "given": "Zeki", "initials": "Z"}, {"family": "Tatli", "given": "Ozge", "initials": "O"}, {"family": "Agaoglu", "given": "Nihat Bugra", "initials": "NB"}, {"family": "Irvem", "given": "Arzu", "initials": "A"}, {"family": "Aydin", "given": "Mehtap", "initials": "M"}, {"family": "Karaali", "given": "Ridvan", "initials": "R"}, {"family": "Gunes", "given": "Mustafa", "initials": "M"}, {"family": "Yesilyurt", "given": "Batuhan", "initials": "B"}, {"family": "Turkez", "given": "Hasan", "initials": "H"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A"}, {"family": "Doganay", "given": "Mehmet", "initials": "M"}, {"family": "Basinoglu", "given": "Filiz", "initials": "F"}, {"family": "Seyahi", "given": "Nurhan", "initials": "N"}, {"family": "Dinler Doganay", "given": "Gizem", "initials": "G"}, {"family": "Doganay", "given": "Hamdi Levent", "initials": "HL"}], "type": "journal article", "published": "2021-03-03", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "16", "issue": "3", "pages": "e0247865", "issn-l": "1932-6203"}, "abstract": "COVID-19 is a global threat with an increasing number of infections. Research on IgG seroprevalence among health care workers (HCWs) is needed to re-evaluate health policies. This study was performed in three pandemic hospitals in Istanbul and Kocaeli. Different clusters of HCWs were screened for SARS-CoV-2 infection. Seropositivity rate among participants was evaluated by chemiluminescent microparticle immunoassay. We recruited 813 non-infected and 119 PCR-confirmed infected HCWs. Of the previously undiagnosed HCWs, 22 (2.7%) were seropositive. Seropositivity rates were highest for cleaning staff (6%), physicians (4%), nurses (2.2%) and radiology technicians (1%). Non-pandemic clinic (6.4%) and ICU (4.3%) had the highest prevalence. HCWs in \"high risk\" group had similar seropositivity rate with \"no risk\" group (2.9 vs 3.5 p = 0.7). These findings might lead to the re-evaluation of infection control and transmission dynamics in hospitals.", "doi": "10.1371/journal.pone.0247865", "pmid": "33657142", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-35740"}], "notes": [], "created": "2021-03-04T14:59:29.060Z", "modified": "2021-03-04T14:59:44.375Z"}, {"entity": "publication", "iuid": "bd36b3d1e82d4558a7b9f1fdd6cd21c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bd36b3d1e82d4558a7b9f1fdd6cd21c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bd36b3d1e82d4558a7b9f1fdd6cd21c0"}}, "title": "In education we trust: on handling the COVID-19 Pandemic in the Swedish welfare state.", "authors": [{"family": "Lindblad", "given": "Sverker", "initials": "S", "orcid": "0000-0003-3481-3686", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/643e57912c7b487abde1d0bb0cb62bcd.json"}}, {"family": "Lindqvist", "given": "Anders", "initials": "A"}, {"family": "Runesdotter", "given": "Caroline", "initials": "C"}, {"family": "W\u00e4rvik", "given": "Gun-Britt", "initials": "GB"}], "type": "journal article", "published": "2021-03-03", "journal": {"title": "Z Erziehungswiss", "issn": "1434-663X", "volume": "24", "issue": "2", "pages": "503-519", "issn-l": null}, "abstract": "Keeping schools open was an active strategy in Sweden to meet the threats of the COVID-19 pandemic. In this article we analyze how a collection of welfare state agents with different tasks, resources and interests in interaction formed an assemblage in their responses to the pandemic and how education thereby became part of a strategy to keep the society going. The inquiries concern what this tells us about education as framed and constrained as a part of society. Our observations are based on statements presented by the government and public agencies, mass media and websites. We identified an assemblage of interwoven agents such as institutions, laws, regulations and recommendations, pandemic manuals, statistics and media. All these were brought together by actions and ideas to handle a pandemic when there were no preventive vaccines. The overarching principle was to educate the population to competent actions in dealing with the pandemic. To keep schools open was part of that principle combined with caretaking ambitions. This assemblage looked like a centralistic machine but it was not; risks were pushed back to local authorities and schools. In conclusion, we note that education is vital in the overarching strategy to deal with the pandemic in Sweden in terms of trust in people and governmentality.", "doi": "10.1007/s11618-021-01001-y", "pmid": "33686342", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7927774"}, {"db": "pii", "key": "1001"}], "notes": [], "created": "2021-03-09T15:38:30.715Z", "modified": "2023-06-19T15:03:30.315Z"}, {"entity": "publication", "iuid": "a0855feda5bb4681ad704142bd8b900e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a0855feda5bb4681ad704142bd8b900e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a0855feda5bb4681ad704142bd8b900e"}}, "title": "Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity.", "authors": [{"family": "Hoffmann", "given": "Markus", "initials": "M"}, {"family": "Hofmann-Winkler", "given": "Heike", "initials": "H"}, {"family": "Smith", "given": "Joan C", "initials": "JC"}, {"family": "Kr\u00fcger", "given": "Nadine", "initials": "N"}, {"family": "Arora", "given": "Prerna", "initials": "P"}, {"family": "S\u00f8rensen", "given": "Lambert K", "initials": "LK"}, {"family": "S\u00f8gaard", "given": "Ole S", "initials": "OS"}, {"family": "Hasselstr\u00f8m", "given": "J\u00f8rgen Bo", "initials": "JB"}, {"family": "Winkler", "given": "Michael", "initials": "M"}, {"family": "Hempel", "given": "Tim", "initials": "T"}, {"family": "Raich", "given": "Llu\u00eds", "initials": "L"}, {"family": "Olsson", "given": "Simon", "initials": "S"}, {"family": "Danov", "given": "Olga", "initials": "O"}, {"family": "Jonigk", "given": "Danny", "initials": "D"}, {"family": "Yamazoe", "given": "Takashi", "initials": "T"}, {"family": "Yamatsuta", "given": "Katsura", "initials": "K"}, {"family": "Mizuno", "given": "Hirotaka", "initials": "H"}, {"family": "Ludwig", "given": "Stephan", "initials": "S"}, {"family": "No\u00e9", "given": "Frank", "initials": "F"}, {"family": "Kjolby", "given": "Mads", "initials": "M"}, {"family": "Braun", "given": "Armin", "initials": "A"}, {"family": "Sheltzer", "given": "Jason M", "initials": "JM"}, {"family": "P\u00f6hlmann", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2021-03-03", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "volume": null, "issue": null, "pages": "103255", "issn-l": null}, "abstract": "Antivirals are needed to combat the COVID-19 pandemic, which is caused by SARS-CoV-2. The clinically-proven protease inhibitor Camostat mesylate inhibits SARS-CoV-2 infection by blocking the virus-activating host cell protease TMPRSS2. However, antiviral activity of Camostat mesylate metabolites and potential viral resistance have not been analyzed. Moreover, antiviral activity of Camostat mesylate in human lung tissue remains to be demonstrated.\n\nWe used recombinant TMPRSS2, reporter particles bearing the spike protein of SARS-CoV-2 or authentic SARS-CoV-2 to assess inhibition of TMPRSS2 and viral entry, respectively, by Camostat mesylate and its metabolite GBPA.\n\nWe show that several TMPRSS2-related proteases activate SARS-CoV-2 and that two, TMPRSS11D and TMPRSS13, are robustly expressed in the upper respiratory tract. However, entry mediated by these proteases was blocked by Camostat mesylate. The Camostat metabolite GBPA inhibited recombinant TMPRSS2 with reduced efficiency as compared to Camostat mesylate. In contrast, both inhibitors exhibited similar antiviral activity and this correlated with the rapid conversion of Camostat mesylate into GBPA in the presence of serum. Finally, Camostat mesylate and GBPA blocked SARS-CoV-2 spread in human lung tissue ex vivo and the related protease inhibitor Nafamostat mesylate exerted augmented antiviral activity.\n\nOur results suggest that SARS-CoV-2 can use TMPRSS2 and closely related proteases for spread in the upper respiratory tract and that spread in the human lung can be blocked by Camostat mesylate and its metabolite GBPA.\n\nNIH, Damon Runyon Foundation, ACS, NYCT, DFG, EU, Berlin Mathematics center MATH+, BMBF, Lower Saxony, Lundbeck Foundation, Novo Nordisk Foundation.", "doi": "10.1016/j.ebiom.2021.103255", "pmid": "33676899", "labels": {"Category: Biochemistry": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2352-3964(21)00048-7"}], "notes": [], "created": "2021-03-09T06:29:35.329Z", "modified": "2021-03-09T06:29:35.339Z"}, {"entity": "publication", "iuid": "ccc828de9ffc4d4faf4cbfa6038f8205", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ccc828de9ffc4d4faf4cbfa6038f8205.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ccc828de9ffc4d4faf4cbfa6038f8205"}}, "title": "The effects of school closures on SARS-CoV-2 among parents and teachers.", "authors": [{"family": "Vlachos", "given": "Jonas", "initials": "J"}, {"family": "Herteg\u00e5rd", "given": "Edvin", "initials": "E"}, {"family": "B Svaleryd", "given": "Helena", "initials": "H"}], "type": "journal article", "published": "2021-03-02", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "issn-l": "0027-8424", "volume": "118", "issue": "9", "pages": null}, "abstract": "To reduce the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), most countries closed schools, despite uncertainty if school closures are an effective containment measure. At the onset of the pandemic, Swedish upper-secondary schools moved to online instruction, while lower-secondary schools remained open. This allows for a comparison of parents and teachers differently exposed to open and closed schools, but otherwise facing similar conditions. Leveraging rich Swedish register data, we connect all students and teachers in Sweden to their families and study the impact of moving to online instruction on the incidence of SARS-CoV-2 and COVID-19. We find that, among parents, exposure to open rather than closed schools resulted in a small increase in PCR-confirmed infections (odds ratio [OR] 1.17; 95% CI [CI95] 1.03 to 1.32). Among lower-secondary teachers, the infection rate doubled relative to upper-secondary teachers (OR 2.01; CI95 1.52 to 2.67). This spilled over to the partners of lower-secondary teachers, who had a higher infection rate than their upper-secondary counterparts (OR 1.29; CI95 1.00 to 1.67). When analyzing COVID-19 diagnoses from healthcare visits and the incidence of severe health outcomes, results are similar for teachers, but weaker for parents and teachers' partners. The results for parents indicate that keeping lower-secondary schools open had minor consequences for the overall transmission of SARS-CoV-2 in society. The results for teachers suggest that measures to protect teachers could be considered.", "doi": "10.1073/pnas.2020834118", "pmid": "33574041", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "2020834118"}, {"db": "URL", "key": "https://doi.org/10.17605/OSF.IO/4ZEGU", "description": "Analysis code"}, {"db": "NA", "key": "Data available from Statistics Sweden, the Public Health Agency, the National Board of Health and Welfare", "description": null}], "notes": [], "created": "2021-02-15T10:48:23.120Z", "modified": "2022-11-23T09:02:06.517Z"}, {"entity": "publication", "iuid": "6fc0a21da50a4bddbdf07a5a63b48e36", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6fc0a21da50a4bddbdf07a5a63b48e36.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6fc0a21da50a4bddbdf07a5a63b48e36"}}, "title": "Protection induced by a human monoclonal antibody recognizing two different epitopes in a conserved region of streptococcal M proteins", "authors": [{"family": "Bahnan", "given": "Wael", "initials": "W"}, {"family": "Happonen", "given": "Lotta", "initials": "L"}, {"family": "Khakzad", "given": "Hamed", "initials": "H"}, {"family": "Ahnlide", "given": "Vibha Kumra", "initials": "VK"}, {"family": "de Neergaard", "given": "Therese", "initials": "T"}, {"family": "Wrighton", "given": "Sebastian", "initials": "S"}, {"family": "Bratanis", "given": "Eleni", "initials": "E"}, {"family": "Tang", "given": "Di", "initials": "D"}, {"family": "Hellmark", "given": "Thomas", "initials": "T"}, {"family": "Bj\u00f6rck", "given": "Lars", "initials": "L"}, {"family": "Shannon", "given": "Oonagh", "initials": "O"}, {"family": "Malmstr\u00f6m", "given": "Lars", "initials": "L"}, {"family": "Malmstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Nordenfelt", "given": "Pontus", "initials": "P"}], "type": "posted-content", "published": "2021-03-02", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.03.01.433494", "pmid": null, "labels": {"Category: Biochemistry": null, "Category: Proteins": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-03-22T12:39:21.164Z", "modified": "2021-03-22T13:33:56.820Z"}, {"entity": "publication", "iuid": "cec1e1228ccc42ad9bca389bad602a9e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cec1e1228ccc42ad9bca389bad602a9e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cec1e1228ccc42ad9bca389bad602a9e"}}, "title": "Has COVID-19 Improved Public Awareness on Oral Hygiene?", "authors": [{"family": "SOROOSHIAN", "given": "Shahryar", "initials": "S"}, {"family": "KUMAR", "given": "Senthil", "initials": "S"}], "type": "journal-article", "published": "2021-03-02", "journal": {"title": "ijph", "issn": "2251-6093", "issn-l": null}, "abstract": null, "doi": "10.18502/ijph.v50i3.5626", "pmid": null, "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-06-28T18:06:14.132Z", "modified": "2021-06-28T18:06:14.163Z"}, {"entity": "publication", "iuid": "564a9c99c97f4c13914ec11dd3809290", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/564a9c99c97f4c13914ec11dd3809290.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/564a9c99c97f4c13914ec11dd3809290"}}, "title": "Epidemiology and transmission characteristics of early COVID-19 cases, 20 January-19 March 2020, in Bavaria, Germany.", "authors": [{"family": "B\u00f6hm", "given": "S", "initials": "S", "orcid": "0000-0002-5807-8092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c4eb44d818744a98bc5e936918ffd690.json"}}, {"family": "Woudenberg", "given": "T", "initials": "T"}, {"family": "Chen", "given": "D", "initials": "D"}, {"family": "Marosevic", "given": "D V", "initials": "DV"}, {"family": "B\u00f6hmer", "given": "M M", "initials": "MM"}, {"family": "Hansen", "given": "L", "initials": "L"}, {"family": "Wallinga", "given": "J", "initials": "J"}, {"family": "Sing", "given": "A", "initials": "A"}, {"family": "Katz", "given": "K", "initials": "K"}], "type": "journal article", "published": "2021-03-02", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": "149", "issue": null, "pages": "e65", "issn-l": null}, "abstract": "Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) led to a significant disease burden and disruptions in health systems. We describe the epidemiology and transmission characteristics of early coronavirus disease 2019 (COVID-19) cases in Bavaria, Germany. Cases were reverse transcription polymerase chain reaction (RT-PCR)-confirmed SARS-CoV-2 infections, reported from 20 January-19 March 2020. The incubation period was estimated using travel history and date of symptom onset. To estimate the serial interval, we identified pairs of index and secondary cases. By 19 March, 3546 cases were reported. A large proportion was exposed abroad (38%), causing further local transmission. Median incubation period of 256 cases with exposure abroad was 3.8 days (95%CI: 3.5-4.2). For 95% of infected individuals, symptom onset occurred within 10.3 days (95%CI: 9.1-11.8) after exposure. The median serial interval, using 53 pairs, was 3.5 days (95%CI: 3.0-4.2; mean: 3.9, s.d.: 2.2). Travellers returning to Germany had an important influence on the spread of SARS-CoV-2 infections in Bavaria in early 2020. Especially in times of low incidence, public health agencies should identify holiday destinations, and areas with ongoing local transmission, to monitor potential importation of SARS-CoV-2 infections. Travellers returning from areas with ongoing community transmission should be advised to quarantine to prevent re-introductions of COVID-19.", "doi": "10.1017/S0950268821000510", "pmid": "33650470", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7985897"}, {"db": "pii", "key": "S0950268821000510"}], "notes": [], "created": "2021-03-03T17:00:47.834Z", "modified": "2023-06-19T15:24:04.172Z"}, {"entity": "publication", "iuid": "ffff55339bad42d49fd284235c6370e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ffff55339bad42d49fd284235c6370e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ffff55339bad42d49fd284235c6370e8"}}, "title": "A genomic region associated with protection against severe COVID-19 is inherited from Neandertals", "authors": [{"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "P\u00e4\u00e4bo", "given": "Svante", "initials": "S"}], "type": "journal-article", "published": "2021-03-02", "journal": {"title": "Proc Natl Acad Sci USA", "issn": "0027-8424", "issn-l": "0027-8424", "volume": "118", "issue": "9", "pages": "e2026309118"}, "abstract": null, "doi": "10.1073/pnas.2026309118", "pmid": null, "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [], "notes": [], "created": "2021-02-17T15:07:25.648Z", "modified": "2021-02-26T08:45:14.519Z"}, {"entity": "publication", "iuid": "35bd0616989944c68f1bb94cceed8411", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/35bd0616989944c68f1bb94cceed8411.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/35bd0616989944c68f1bb94cceed8411"}}, "title": "Time series analysis and mechanistic modelling of heterogeneity and sero-reversion in antibody responses to mild SARS\u2011CoV-2 infection.", "authors": [{"family": "Manisty", "given": "Charlotte", "initials": "C"}, {"family": "Treibel", "given": "Thomas Alexander", "initials": "TA"}, {"family": "Jensen", "given": "Melanie", "initials": "M"}, {"family": "Semper", "given": "Amanda", "initials": "A"}, {"family": "Joy", "given": "George", "initials": "G"}, {"family": "Gupta", "given": "Rishi K", "initials": "RK"}, {"family": "Cutino-Moguel", "given": "Teresa", "initials": "T"}, {"family": "Andiapen", "given": "Mervyn", "initials": "M"}, {"family": "Jones", "given": "Jessica", "initials": "J"}, {"family": "Taylor", "given": "Stephen", "initials": "S"}, {"family": "Otter", "given": "Ashley", "initials": "A"}, {"family": "Pade", "given": "Corrina", "initials": "C"}, {"family": "Gibbons", "given": "Joseph", "initials": "J"}, {"family": "Lee", "given": "Jason", "initials": "J"}, {"family": "Bacon", "given": "Joanna", "initials": "J"}, {"family": "Thomas", "given": "Steve", "initials": "S"}, {"family": "Moon", "given": "Chris", "initials": "C"}, {"family": "Jones", "given": "Meleri", "initials": "M"}, {"family": "Williams", "given": "Dylan", "initials": "D"}, {"family": "Lambourne", "given": "Jonathan", "initials": "J"}, {"family": "Fontana", "given": "Marianna", "initials": "M"}, {"family": "Altmann", "given": "Daniel M", "initials": "DM"}, {"family": "Boyton", "given": "Rosemary", "initials": "R"}, {"family": "Maini", "given": "Mala", "initials": "M"}, {"family": "McKnight", "given": "Aine", "initials": "A"}, {"family": "Chain", "given": "Benjamin", "initials": "B"}, {"family": "Noursadeghi", "given": "Mahdad", "initials": "M"}, {"family": "Moon", "given": "James C", "initials": "JC"}], "type": "journal article", "published": "2021-03-01", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": "65", "issue": null, "pages": "103259"}, "abstract": "SARS-CoV-2 serology is used to identify prior infection at individual and at population level. Extended longitudinal studies with multi-timepoint sampling to evaluate dynamic changes in antibody levels are required to identify the time horizon in which these applications of serology are valid, and to explore the longevity of protective humoral immunity.\r\n\r\nHealthcare workers were recruited to a prospective cohort study from the first SARS-CoV-2 epidemic peak in London, undergoing weekly symptom screen, viral PCR and blood sampling over 16-21 weeks. Serological analysis (n =12,990) was performed using semi-quantitative Euroimmun IgG to viral spike S1 domain and Roche total antibody to viral nucleocapsid protein (NP) assays. Comparisons were made to pseudovirus neutralizing antibody measurements.\r\n\r\nA total of 157/729 (21.5%) participants developed positive SARS-CoV-2 serology by one or other assay, of whom 31.0% were asymptomatic and there were no deaths. Peak Euroimmun anti-S1 and Roche anti-NP measurements correlated (r = 0.57, p<0.0001) but only anti-S1 measurements correlated with near-contemporary pseudovirus neutralising antibody titres (measured at 16-18 weeks, r = 0.57, p<0.0001). By 21 weeks' follow-up, 31/143 (21.7%) anti-S1 and 6/150 (4.0%) anti-NP measurements reverted to negative. Mathematical modelling revealed faster clearance of anti-S1 compared to anti-NP (median half-life of 2.5 weeks versus 4.0 weeks), earlier transition to lower levels of antibody production (median of 8 versus 13 weeks), and greater reductions in relative antibody production rate after the transition (median of 35% versus 50%).\r\n\r\nMild SARS-CoV-2 infection is associated with heterogeneous serological responses in Euroimmun anti-S1 and Roche anti-NP assays. Anti-S1 responses showed faster rates of clearance, more rapid transition from high to low level production rate and greater reduction in production rate after this transition. In mild infection, anti-S1 serology alone may underestimate incident infections. The mechanisms that underpin faster clearance and lower rates of sustained anti-S1 production may impact on the longevity of humoral immunity.\r\n\r\nCharitable donations via Barts Charity, Wellcome Trust, NIHR.", "doi": "10.1016/j.ebiom.2021.103259", "pmid": "33662833", "labels": {"Category: Proteins": null, "Category: Genomics & transcriptomics": null, "Type: Journal article": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "S2352-3964(21)00052-9"}, {"db": "pmc", "key": "PMC7920816"}, {"db": "URL", "key": "https://covid-consortium.com/", "description": "Applications for access to the individual participant de-identified data (including data dictionaries) and samples can be made to the access committee"}], "notes": [], "created": "2021-03-06T10:15:49.479Z", "modified": "2021-03-12T10:31:44.422Z"}, {"entity": "publication", "iuid": "a956b3bcb88f402da5231b8f655fa49e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a956b3bcb88f402da5231b8f655fa49e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a956b3bcb88f402da5231b8f655fa49e"}}, "title": "Why people failed to adhere to COVID-19 preventive behaviors? Perspectives from an integrated behavior change model", "authors": [{"family": "Chan", "given": "Derwin K C", "initials": "DKC", "orcid": "0000-0001-8200-0263", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37f65888980c44a4a60077bfb9c2a943.json"}}, {"family": "Zhang", "given": "Chun Qing", "initials": "CQ"}, {"family": "Weman-Josefsson", "given": "Karin", "initials": "K"}], "type": "journal-article", "published": "2021-03-00", "journal": {"title": "Infect Control Hosp Epidemiol", "issn": "0899-823X", "volume": "42", "issue": "3", "pages": "375-376", "issn-l": null}, "abstract": null, "doi": "10.1017/ice.2020.245", "pmid": "32408917", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0899823X20002457"}, {"db": "pmc", "key": "PMC7253766"}], "notes": [], "created": "2020-12-10T08:49:50.394Z", "modified": "2021-12-06T13:14:00.408Z"}, {"entity": "publication", "iuid": "d3240cf5394c47d98e0b3177006fc717", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3240cf5394c47d98e0b3177006fc717.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3240cf5394c47d98e0b3177006fc717"}}, "title": "What do people hospitalised with COVID-19 think about their care? Results of a satisfaction survey during the first wave of COVID-19 in Liverpool.", "authors": [{"family": "Wu", "given": "Meng-San", "initials": "MS"}, {"family": "Watson", "given": "Rebecca", "initials": "R"}, {"family": "Hayat", "given": "Fatima", "initials": "F"}, {"family": "Ratcliffe", "given": "Libuse", "initials": "L"}, {"family": "Beadsworth", "given": "Mike Bj", "initials": "MB"}, {"family": "McKenna", "given": "Mark", "initials": "M"}, {"family": "Corney", "given": "Daniel", "initials": "D"}, {"family": "Plum", "given": "Catherine", "initials": "C"}, {"family": "Macfarlane", "given": "Jamie-Leigh", "initials": "JL"}, {"family": "Matareed", "given": "Maisoon", "initials": "M"}, {"family": "Butt", "given": "Sundas", "initials": "S"}, {"family": "Gupta", "given": "Sandipika", "initials": "S"}, {"family": "Hine", "given": "Paul", "initials": "P"}, {"family": "Defres", "given": "Sylviane", "initials": "S"}, {"family": "Wingfield", "given": "Tom", "initials": "T"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Future Healthc J", "issn": "2514-6645", "volume": "8", "issue": "1", "pages": "e70-e75", "issn-l": null}, "abstract": "Despite huge advances in vaccines, testing and treatments for COVID-19, there is negligible evidence on the perceptions of people hospitalised with COVID-19 about the care they received. To address this, we developed a satisfaction survey for people with COVID-19 admitted to our hospital during the first COVID-19 wave in Liverpool. Of those invited, 98/160 (61%) responded, of whom 94/98 (96%) completed the survey. Respondents rated overall care highly (mean 4.7/5) and 89/94 (95%) reported that they would recommend the hospital to friends and/or family. Most respondents felt safe on the ward (94%), with privacy maintained (93%) and pain well managed (90%). Fewer than two-thirds (63%) of respondents considered themselves adequately consulted regarding medications and side effects. Sleep and food/drink quality were also highlighted as areas for improvement. To overcome the issues raised, we generated a 'COVID-19 practice pointers' poster within an integrated educational bundle on COVID-19 wards. The impact of the bundle on perceptions of people hospitalised with COVID-19 will be evaluated in people hospitalised with COVID-19 in Liverpool in 2021. Whether hospitalised for COVID-19 or other conditions, our survey results are a timely reminder of the importance of involving patients in shaping the care that they receive.", "doi": "10.7861/fhj.2020-0260", "pmid": "33791480", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "futurehealth"}, {"db": "pmc", "key": "PMC8004304"}], "notes": [], "created": "2021-04-06T10:43:07.126Z", "modified": "2021-04-06T10:43:07.149Z"}, {"entity": "publication", "iuid": "7571e2cc6b564849b2e75ed1c8c76404", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7571e2cc6b564849b2e75ed1c8c76404.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7571e2cc6b564849b2e75ed1c8c76404"}}, "title": "Very little influenza in the WHO European Region during the 2020/21 season, weeks 40 2020 to 8 2021.", "authors": [{"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Mook", "given": "Piers", "initials": "P"}, {"family": "Lamb", "given": "Favelle", "initials": "F"}, {"family": "Ferland", "given": "Lisa", "initials": "L"}, {"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "Amato-Gauci", "given": "Andrew J", "initials": "AJ"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "European Influenza Surveillance Network", "given": "", "initials": ""}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "11", "pages": null}, "abstract": "Between weeks 40 2020 and 8 2021, the World Health Organization European Region experienced a 99.8% reduction in sentinel influenza virus positive detections (33/25,606 tested; 0.1%) relative to an average of 14,966/39,407 (38.0%; p < 0.001) over the same time in the previous six seasons. COVID-19 pandemic public health and physical distancing measures may have extinguished the 2020/21 European seasonal influenza epidemic with just a few sporadic detections of all viral subtypes. This might possibly continue during the remainder of the influenza season.", "doi": "10.2807/1560-7917.ES.2021.26.11.2100221", "pmid": "33739256", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-22T10:31:59.380Z", "modified": "2021-06-18T14:39:21.838Z"}, {"entity": "publication", "iuid": "05093540bf5441dfb79be809471bc698", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/05093540bf5441dfb79be809471bc698.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/05093540bf5441dfb79be809471bc698"}}, "title": "Towards a sensitive and accurate interpretation of molecular testing for SARS-CoV-2: a rapid review of 264 studies.", "authors": [{"family": "Stanoeva", "given": "Kamelia R", "initials": "KR"}, {"family": "van der Eijk", "given": "Annemiek A", "initials": "AA"}, {"family": "Meijer", "given": "Adam", "initials": "A"}, {"family": "Kortbeek", "given": "Laetitia M", "initials": "LM"}, {"family": "Koopmans", "given": "Marion P G", "initials": "MPG"}, {"family": "Reusken", "given": "Chantal B E M", "initials": "CBEM"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "26", "issue": "10", "issn-l": null}, "abstract": "BackgroundSensitive molecular diagnostics and correct test interpretation are crucial for accurate COVID-19 diagnosis and thereby essential for good clinical practice. Furthermore, they are a key factor in outbreak control where active case finding in combination with isolation and contact tracing are crucial.AimWith the objective to inform the public health and laboratory responses to the pandemic, we reviewed current published knowledge on the kinetics of SARS-CoV-2 infection as assessed by RNA molecular detection in a wide range of clinical samples.MethodsWe performed an extensive search on studies published between 1 December 2019 and 15 May 2020, reporting on molecular detection and/or isolation of SARS-CoV-2 in any human laboratory specimen.ResultsWe compiled a dataset of 264 studies including 32,515 COVID-19 cases, and additionally aggregated data points (n = 2,777) from sampling of 217 adults with known infection timeline. We summarised data on SARS-CoV-2 detection in the respiratory and gastrointestinal tract, blood, oral fluid, tears, cerebrospinal fluid, peritoneal fluid, semen, vaginal fluid; where provided, we also summarised specific observations on SARS-CoV-2 detection in pregnancy, infancy, children, adolescents and immunocompromised individuals.ConclusionOptimal SARS-CoV-2 molecular testing relies on choosing the most appropriate sample type, collected with adequate sampling technique, and with the infection timeline in mind. We outlined knowledge gaps and directions for future well-documented systematic studies.", "doi": "10.2807/1560-7917.ES.2021.26.10.2001134", "pmid": "33706863", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-03-17T07:09:27.560Z", "modified": "2021-03-17T07:09:27.570Z"}, {"entity": "publication", "iuid": "cb6807f591e447ac8b78e9df7a413cd3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cb6807f591e447ac8b78e9df7a413cd3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cb6807f591e447ac8b78e9df7a413cd3"}}, "title": "The new normal of social psychology in the face of the COVID-19 pandemic: Insights and advice from leaders in the field.", "authors": [{"family": "Tam", "given": "Kim-Pong", "initials": "KP"}, {"family": "Leung", "given": "Angela K-Y", "initials": "AK"}, {"family": "Khan", "given": "Sammyh", "initials": "S"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Asian J Soc Psychol", "issn": "1367-2223", "volume": "24", "issue": "1", "pages": "8-9", "issn-l": null}, "abstract": null, "doi": "10.1111/ajsp.12468", "pmid": "33821135", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "AJSP12468"}, {"db": "pmc", "key": "PMC8014449"}], "notes": [], "created": "2021-04-07T10:10:20.671Z", "modified": "2021-04-07T10:10:48.343Z"}, {"entity": "publication", "iuid": "6887e04239de45d69ce855e4c8d0b90f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6887e04239de45d69ce855e4c8d0b90f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6887e04239de45d69ce855e4c8d0b90f"}}, "title": "The Psychological Functioning in the COVID-19 Pandemic and Its Association with Psychological Flexibility and Broader Functioning in People with Chronic Pain", "authors": [{"family": "Yu", "given": "Lin", "initials": "L"}, {"family": "Kioskli", "given": "Kitty", "initials": "K"}, {"family": "McCracken", "given": "Lance M", "initials": "LM"}], "type": "journal-article", "published": "2021-03-00", "journal": {"title": "The Journal of Pain", "issn": "1526-5900", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.jpain.2021.02.011", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-03-09T06:28:16.006Z", "modified": "2021-03-09T06:28:32.481Z"}, {"entity": "publication", "iuid": "5a5780c724224d5eb0b814962d3ac220", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5a5780c724224d5eb0b814962d3ac220.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5a5780c724224d5eb0b814962d3ac220"}}, "title": "Symptom clusters in COVID-19: A potential clinical prediction tool from the COVID Symptom Study app.", "authors": [{"family": "Sudre", "given": "Carole H", "initials": "CH", "orcid": "0000-0001-5753-428X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c26472813fed4007a8757af771de1802.json"}}, {"family": "Lee", "given": "Karla A", "initials": "KA"}, {"family": "Lochlainn", "given": "Mary Ni", "initials": "MN", "orcid": "0000-0001-5702-1759", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/07cc5b481cc441988525d0a1b2911a6d.json"}}, {"family": "Varsavsky", "given": "Thomas", "initials": "T"}, {"family": "Murray", "given": "Benjamin", "initials": "B", "orcid": "0000-0002-2413-923X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebec738df0224bf4874fd6c08fd23fae.json"}}, {"family": "Graham", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-4170-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f5f4e19812a46ed9e873732ec25e28d.json"}}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/874802ae65824a90ba50eabdeabb8356.json"}}, {"family": "Modat", "given": "Marc", "initials": "M"}, {"family": "Bowyer", "given": "Ruth C E", "initials": "RCE"}, {"family": "Nguyen", "given": "Long H", "initials": "LH", "orcid": "0000-0002-5436-4219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b076677f62c148b2abdc7225d60be8fc.json"}}, {"family": "Drew", "given": "David A", "initials": "DA", "orcid": "0000-0002-8813-0816", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd3a2cffdc104f18b8684cf4f27d68b2.json"}}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Ma", "given": "Wenjie", "initials": "W", "orcid": "0000-0001-9894-7072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cc7d1aa610c04d67bd6c9b57b34b5ace.json"}}, {"family": "Guo", "given": "Chuan-Guo", "initials": "CG", "orcid": "0000-0002-0657-473X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1be56974ac7414e9db038e4e8c43982.json"}}, {"family": "Lo", "given": "Chun-Han", "initials": "CH", "orcid": "0000-0001-8202-4513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2a0d9111318f4084b64f47b5b56c8c85.json"}}, {"family": "Ganesh", "given": "Sajaysurya", "initials": "S", "orcid": "0000-0002-3720-4176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6dbf91180806442082ce6732c1b75923.json"}}, {"family": "Buwe", "given": "Abubakar", "initials": "A", "orcid": "0000-0003-4086-8616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeba04fb389b4d2d8c0e9b29f4424d73.json"}}, {"family": "Pujol", "given": "Joan Capdevila", "initials": "JC"}, {"family": "du Cadet", "given": "Julien Lavigne", "initials": "JL", "orcid": "0000-0001-8034-7167", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fd59698f58fa4129a5d07a8315c0c81b.json"}}, {"family": "Visconti", "given": "Alessia", "initials": "A", "orcid": "0000-0003-4144-2019", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ce0429ccf674827aedbb8d05a53145c.json"}}, {"family": "Freidin", "given": "Maxim B", "initials": "MB", "orcid": "0000-0002-1439-6259", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/978702cb6b4c44d7aaa5839543afa5df.json"}}, {"family": "El-Sayed Moustafa", "given": "Julia S", "initials": "JS", "orcid": "0000-0001-6963-6654", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b121ad24f0349a08b785a24a7a1ee3e.json"}}, {"family": "Falchi", "given": "Mario", "initials": "M", "orcid": "0000-0002-5646-1004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0a8220dcbcf45278fa264e153f97650.json"}}, {"family": "Davies", "given": "Richard", "initials": "R", "orcid": "0000-0003-2050-3994", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b82cc92615f462d9af0153a6fb94fde.json"}}, {"family": "Gomez", "given": "Maria F", "initials": "MF", "orcid": "0000-0001-6210-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e09e37219c4f42c8a7b3a982da523859.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f34c0d3602439abe6096293c7c732d.json"}}, {"family": "Cardoso", "given": "M Jorge", "initials": "MJ", "orcid": "0000-0003-1284-2558", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0ed3abec67644e186650e1d1dcbbe0b.json"}}, {"family": "Wolf", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-0530-2257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/572301ca9376405594db9918c4051f84.json"}}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74cf1f7094744ee289fa5df041e7cb5b.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-7284-6767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eeefbf47fd384d5390109fe1a903bd18.json"}}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}, {"family": "Ourselin", "given": "S\u00e9bastien", "initials": "S", "orcid": "0000-0002-5694-5340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74c7b9b1633144879042d198c7205656.json"}}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "7", "issue": "12", "issn-l": "2375-2548"}, "abstract": "As no one symptom can predict disease severity or the need for dedicated medical support in coronavirus disease 2019 (COVID-19), we asked whether documenting symptom time series over the first few days informs outcome. Unsupervised time series clustering over symptom presentation was performed on data collected from a training dataset of completed cases enlisted early from the COVID Symptom Study Smartphone application, yielding six distinct symptom presentations. Clustering was validated on an independent replication dataset between 1 and 28 May 2020. Using the first 5 days of symptom logging, the ROC-AUC (receiver operating characteristic - area under the curve) of need for respiratory support was 78.8%, substantially outperforming personal characteristics alone (ROC-AUC 69.5%). Such an approach could be used to monitor at-risk patients and predict medical resource requirements days before they are required.", "doi": "10.1126/sciadv.abd4177", "pmid": "33741586", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7978420"}, {"db": "pii", "key": "7/12/eabd4177"}], "notes": [], "created": "2021-03-22T10:31:12.422Z", "modified": "2023-06-19T15:27:39.430Z"}, {"entity": "publication", "iuid": "de99b38176ee4b739ce67799af265121", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/de99b38176ee4b739ce67799af265121.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/de99b38176ee4b739ce67799af265121"}}, "title": "Sweden: Non-binding Rules against the Pandemic - Formalism, Pragmatism and Some Legal Realism.", "authors": [{"family": "Wenander", "given": "Henrik", "initials": "H"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Eur J Risk Regul", "issn": "1867-299X", "issn-l": null, "volume": "12", "issue": "1", "pages": "127-142"}, "abstract": "Swedish measures to fight the spread of COVID-19 differ from the strategies used in other comparable countries. In contrast to the lockdown approach that has been applied in many European countries, the Swedish strategy has been based to a substantial extent on individuals taking responsibility under non-binding recommendations. This contribution explores the Swedish strategy from a constitutional and administrative law perspective, highlighting the tension between the formalist system for delegating norms under the Swedish Constitution and the pragmatic use of non-binding rules such as the \"General Recommendations\" adopted by the Public Health Agency. The article concludes that the official use of soft law instruments is confusing from a legal perspective, because non-binding rules do not offer the traditional formal mechanisms for legal protection, the publication of norms or accountability. The legal-realist approach of the Supreme Administrative Court's case law, however, has the potential of balancing some of the unfortunate effects arising from the Swedish combination of formalism and pragmatism.", "doi": "10.1017/err.2021.2", "pmid": "34191958", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S1867299X21000027"}, {"db": "pmc", "key": "PMC8060606"}], "notes": [], "created": "2021-07-05T14:25:58.305Z", "modified": "2022-11-23T09:02:34.506Z"}, {"entity": "publication", "iuid": "90e7835a18214ccabf92e7659c5a9709", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90e7835a18214ccabf92e7659c5a9709.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90e7835a18214ccabf92e7659c5a9709"}}, "title": "Shared genetic etiology between idiopathic pulmonary fibrosis and COVID-19 severity", "authors": [{"family": "Fadista", "given": "Jo\u00e3o", "initials": "J", "orcid": "0000-0003-2539-634X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dae453c1a93e417caeb346ac4cdc48ed.json"}}, {"family": "Kraven", "given": "Luke M", "initials": "LM"}, {"family": "Karjalainen", "given": "Juha", "initials": "J"}, {"family": "Andrews", "given": "Shea J", "initials": "SJ"}, {"family": "Geller", "given": "Frank", "initials": "F"}, {"family": "Baillie", "given": "J Kenneth", "initials": "JK"}, {"family": "Wain", "given": "Louise V", "initials": "LV"}, {"family": "Jenkins", "given": "R Gisli", "initials": "RG"}, {"family": "Feenstra", "given": "Bjarke", "initials": "B"}], "type": "journal-article", "published": "2021-03-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": "65", "issue": null, "pages": "103277"}, "abstract": "Idiopathic pulmonary fibrosis (IPF) is a complex lung disease, characterized by progressive lung scarring. Severe COVID-19 is associated with substantial pneumonitis and has a number of shared major risk factors with IPF. This study aimed to determine the genetic correlation between IPF and severe COVID-19 and assess a potential causal role of genetically increased risk of IPF on COVID-19 severity.\r\n\r\nThe genetic correlation between IPF and COVID-19 severity was estimated with linkage disequilibrium (LD) score regression. We performed a Mendelian randomization (MR) study for IPF causality in COVID-19. Genetic variants associated with IPF susceptibility (P<5 \u00d7 10 -8) in previous genome-wide association studies (GWAS) were used as instrumental variables (IVs). Effect estimates of those IVs on COVID-19 severity were gathered from the GWAS meta-analysis by the COVID-19 Host Genetics Initiative (4,336 cases & 623,902 controls).\r\n\r\nWe detected a positive genetic correlation of IPF with COVID-19 severity (rg=0\u00b731 [95% CI 0\u00b704-0\u00b757], P = 0\u00b7023). The MR estimates for severe COVID-19 did not reveal any genetic association (OR 1\u00b705, [95% CI 0\u00b792-1\u00b720], P = 0\u00b743). However, outlier analysis revealed that the IPF risk allele rs35705950 at MUC5B had a different effect compared with the other variants. When rs35705950 was excluded, MR results provided evidence that genetically increased risk of IPF has a causal effect on COVID-19 severity (OR 1\u00b721, [95% CI 1\u00b706-1\u00b738], P = 4\u00b724 \u00d7 10 -3). Furthermore, the IPF risk-allele at MUC5B showed an apparent protective effect against COVID-19 hospitalization only in older adults (OR 0\u00b786, [95% CI 0\u00b773-1\u00b700], P = 2\u00b799 \u00d7 10-2) .\r\n\r\nThe strongest genetic determinant of IPF, rs35705950 at MUC5B, seems to confer protection against COVID-19, whereas the combined effect of all other IPF risk loci seem to confer risk of COVID-19 severity. The observed effect of rs35705950 could either be due to protective effects of mucin over-production on the airways or a consequence of selection bias due to (1) a patient group that is heavily enriched for the rs35705950 T undertaking strict self-isolation and/or (2) due to survival bias of the rs35705950 non-IPF risk allele carriers. Due to the diverse impact of IPF causal variants on SARS-CoV-2 infection, with a possible selection bias as an explanation, further investigation is needed to address this apparent paradox between variance at MUC5B and other IPF genetic risk factors.\r\n\r\nNovo Nordisk Foundation and Oak Foundation.", "doi": "10.1016/j.ebiom.2021.103277", "pmid": "33714028", "labels": {"Category: Genomics & transcriptomics": null, "Type: Journal article": null}, "xrefs": [{"db": "URL", "key": "https://github.com/genomicsITER/PFgenetics", "description": "Variant summary data available on request"}, {"db": "URL", "key": "https://www.covid19hg.org/results/", "description": "COVID-19 Host Genetics Initiative (HGI) GWAS metaanalysis"}], "notes": [], "created": "2021-01-07T16:51:10.098Z", "modified": "2022-07-07T09:55:41.690Z"}, {"entity": "publication", "iuid": "94f5f09c0d0e43ba9e96d2a5e95d0ed4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/94f5f09c0d0e43ba9e96d2a5e95d0ed4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/94f5f09c0d0e43ba9e96d2a5e95d0ed4"}}, "title": "Risk prediction of COVID-19 incidence and mortality in a large multi-national hemodialysis cohort: implications for management of the pandemic in outpatient hemodialysis settings.", "authors": [{"family": "Haarhaus", "given": "Mathias", "initials": "M"}, {"family": "Santos", "given": "Carla", "initials": "C"}, {"family": "Haase", "given": "Michael", "initials": "M"}, {"family": "Mota Veiga", "given": "Pedro", "initials": "P"}, {"family": "Lucas", "given": "Carlos", "initials": "C"}, {"family": "Macario", "given": "Fernando", "initials": "F"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Clin Kidney J", "issn": "2048-8505", "volume": "14", "issue": "3", "pages": "805-813", "issn-l": null}, "abstract": "Experiences from the first wave of the 2019 coronavirus disease (COVID-19) pandemic can aid in the development of future preventive strategies. To date, risk prediction models for COVID-19-related incidence and outcomes in hemodialysis (HD) patients are missing.\n\nWe developed risk prediction models for COVID-19 incidence and mortality among HD patients. We studied 38 256 HD patients from a multi-national dialysis cohort between 3 March and 3 July 2020. Risk prediction models were developed and validated, based on predictors readily available in outpatient HD units. We compared mortality among patients with and without COVID-19, matched for age, sex and diabetes.\n\nDuring the observational period, 1259 patients (3.3%) acquired COVID-19. Of these, 62% were hospitalized or died. Mortality was 22% among COVID-19 patients with odds ratios 219.8 [95% confidence interval (CI) 80.6-359] to 342.7 (95% CI 60.6-13 595.1), compared to matched patients without COVID-19. Since the first wave of the pandemic affected most European countries during the study, the risk prediction model for incidence of COVID-19 was developed and validated in European patients only [ N = 22 826 area under the ROC curve(AUC)Dev 0.64, AUCVal 0.69]. The model for prediction of mortality was developed in all COVID-19 patients (AUCDev 0.71, AUCVal 0.78). Angiotensin receptor blockers were independently associated with a lower incidence of COVID-19 in European patients.\n\nWe identified modifiable risk factors for COVID-19 incidence and outcome in HD patients. Our risk prediction tools can be readily applied in clinical practice. This can aid in the development of preventive strategies for future waves of COVID-19.", "doi": "10.1093/ckj/sfab037", "pmid": "33777363", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "sfab037"}, {"db": "pmc", "key": "PMC7929029"}], "notes": [], "created": "2021-03-30T12:25:19.508Z", "modified": "2021-03-30T12:25:19.524Z"}, {"entity": "publication", "iuid": "c58d689fb71f4c4b80daabc3511108e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c58d689fb71f4c4b80daabc3511108e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c58d689fb71f4c4b80daabc3511108e8"}}, "title": "Risk factors for COVID-19 diagnosis, hospitalization, and subsequent all-cause mortality in Sweden: a nationwide study.", "authors": [{"family": "Bergman", "given": "Jonathan", "initials": "J", "orcid": "0000-0003-1904-6140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/da94cb04b9114549bcc1775090d0de61.json"}}, {"family": "Ballin", "given": "Marcel", "initials": "M", "orcid": "0000-0002-9638-7208", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/088ce3ef36e347ebb3a4f90d8e6a1850.json"}}, {"family": "Nordstr\u00f6m", "given": "Anna", "initials": "A", "orcid": "0000-0003-3534-456X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/26229455bc3d42f6aea6b541c4d74b48.json"}}, {"family": "Nordstr\u00f6m", "given": "Peter", "initials": "P", "orcid": "0000-0003-2924-508X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1186e45ff19c4b30888c4751faea3c15.json"}}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Eur J Epidemiol", "issn": "1573-7284", "issn-l": "0393-2990", "volume": "36", "issue": "3", "pages": "287-298"}, "abstract": "We conducted a nationwide, registry-based study to investigate the importance of 34 potential risk factors for coronavirus disease 2019 (COVID-19) diagnosis, hospitalization (with or without intensive care unit [ICU] admission), and subsequent all-cause mortality. The study population comprised all COVID-19 cases confirmed in Sweden by mid-September 2020 (68,575 non-hospitalized, 2494 ICU hospitalized, and 13,589 non-ICU hospitalized) and 434,081 randomly sampled general-population controls. Older age was the strongest risk factor for hospitalization, although the odds of ICU hospitalization decreased after 60-69 years and, after controlling for other risk factors, the odds of non-ICU hospitalization showed no trend after 40-49 years. Residence in a long-term care facility was associated with non-ICU hospitalization. Male sex and the presence of at least one investigated comorbidity or prescription medication were associated with both ICU and non-ICU hospitalization. Three comorbidities associated with both ICU and non-ICU hospitalization were asthma, hypertension, and Down syndrome. History of cancer was not associated with COVID-19 hospitalization, but cancer in the past year was associated with non-ICU hospitalization, after controlling for other risk factors. Cardiovascular disease was weakly associated with non-ICU hospitalization for COVID-19, but not with ICU hospitalization, after adjustment for other risk factors. Excess mortality was observed in both hospitalized and non-hospitalized COVID-19 cases. These results confirm that severe COVID-19 is related to age, sex, and comorbidity in general. The study provides new evidence that hypertension, asthma, Down syndrome, and residence in a long-term care facility are associated with severe COVID-19.", "doi": "10.1007/s10654-021-00732-w", "pmid": "33704634", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7946619"}, {"db": "pii", "key": "10.1007/s10654-021-00732-w"}], "notes": [], "created": "2021-03-12T06:42:36.663Z", "modified": "2023-07-13T11:27:54.874Z"}, {"entity": "publication", "iuid": "60be0de57e6441208b155f92091e203b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60be0de57e6441208b155f92091e203b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60be0de57e6441208b155f92091e203b"}}, "title": "Noise measurements as a proxy to evaluating the response to recommendations in times of crisis: An update analysis of the transition to the second wave of the CoViD-19 pandemic in Central Stockholm, Sweden.", "authors": [{"family": "Rumpler", "given": "Romain", "initials": "R"}, {"family": "Venkataraman", "given": "Siddharth", "initials": "S"}, {"family": "G\u00f6ransson", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "J Acoust Soc Am", "issn": "1520-8524", "volume": "149", "issue": "3", "pages": "1838", "issn-l": null}, "abstract": "Sweden stands out among the other European countries by the degree of restrictive measures taken towards handling the 2019 coronavirus outbreak, associated with the CoViD-19 pandemic. While several governments have imposed a nationwide total or partial lockdown to slow down the spread of the virus, the Swedish government has opted for a recommendation-based approach together with a few imposed restrictions. In a previous contribution by the authors, the impact of the Swedish strategy was observed through the monitored variation of the city noise levels during a period associated with the so-called \"first wave\" of the pandemic in Stockholm. A very strong impact of these recommendations was shown on the evolution of the noise levels in central Stockholm. This highlighted the potential of acoustic sensor networks both for enforcement of regulation and monitoring of the effectiveness of their implementation. The present contribution presents a follow-up to this urban noise monitoring in central Stockholm, Sweden, for the period leading to the so-called \"second wave\" of the pandemic in Europe. Both the evolution of adherence to the recommendations and the impact of the recurrence of cases combined with reinforced recommendations are observed through the evolution of the measured noise levels. While the measurements show a gradual lower level of compliance, in particular, past the summer break, these also show again a rapid response to the reinforced recommendations issued by the authorities in mid-fall of 2020. These observations thus confirm the potential associated with detailed urban noise monitoring, for instance here acting as a proxy to evaluating the response to recommendations or restrictions in times of crisis.", "doi": "10.1121/10.0003778", "pmid": "33765773", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-03-29T09:15:50.369Z", "modified": "2021-03-29T09:15:50.385Z"}, {"entity": "publication", "iuid": "4a726c03e1814efc87b21b7679305fcc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4a726c03e1814efc87b21b7679305fcc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4a726c03e1814efc87b21b7679305fcc"}}, "title": "Monitoring of human coronaviruses in Belgian primary care and hospitals, 2015\u201320: a surveillance study", "authors": [{"family": "Fischer", "given": "Natalie", "initials": "N"}, {"family": "Dauby", "given": "Nicolas", "initials": "N"}, {"family": "Bossuyt", "given": "Nathalie", "initials": "N"}, {"family": "Reynders", "given": "Marijke", "initials": "M"}, {"family": "G\u00e9rard", "given": "Mich\u00e8le", "initials": "M"}, {"family": "Lacor", "given": "Patrick", "initials": "P"}, {"family": "Daelemans", "given": "Siel", "initials": "S"}, {"family": "Lissoir", "given": "B\u00e9n\u00e9dicte", "initials": "B"}, {"family": "Holemans", "given": "Xavier", "initials": "X"}, {"family": "Magerman", "given": "Koen", "initials": "K"}, {"family": "Jouck", "given": "Door", "initials": "D"}, {"family": "Bourgeois", "given": "Marc", "initials": "M"}, {"family": "Delaere", "given": "B\u00e9n\u00e9dicte", "initials": "B"}, {"family": "Quoilin", "given": "Sophie", "initials": "S"}, {"family": "Van Gucht", "given": "Steven", "initials": "S"}, {"family": "Thomas", "given": "Isabelle", "initials": "I"}, {"family": "Barbezange", "given": "Cyril", "initials": "C"}, {"family": "Subissi", "given": "Lorenzo", "initials": "L"}], "type": "journal-article", "published": "2021-03-00", "journal": {"title": "The Lancet Microbe", "issn": "2666-5247", "issn-l": "2666-5247", "volume": "2", "issue": "3", "pages": "e105-e114"}, "abstract": "Seasonal human coronaviruses (hCoVs) broadly circulate in humans. Their epidemiology and effect on the spread of emerging coronaviruses has been neglected thus far. We aimed to elucidate the epidemiology and burden of disease of seasonal hCoVs OC43, NL63, and 229E in patients in primary care and hospitals in Belgium between 2015 and 2020.\r\n\r\nWe retrospectively analysed data from the national influenza surveillance networks in Belgium during the winter seasons of 2015-20. Respiratory specimens were collected through the severe acute respiratory infection (SARI) and the influenza-like illness networks from patients with acute respiratory illness with onset within the previous 10 days, with measured or reported fever of 38\u00b0C or greater, cough, or dyspnoea; and for patients admitted to hospital for at least one night. Potential risk factors were recorded and patients who were admitted to hospital were followed up for the occurrence of complications or death for the length of their hospital stay. All samples were analysed by multiplex quantitative RT-PCRs for respiratory viruses, including seasonal hCoVs OC43, NL63, and 229E. We estimated the prevalence and incidence of seasonal hCoV infection, with or without co-infection with other respiratory viruses. We evaluated the association between co-infections and potential risk factors with complications or death in patients admitted to hospital with seasonal hCoV infections by age group. Samples received from week 8, 2020, were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).\r\n\r\n2573 primary care and 6494 hospital samples were included in the study. 161 (6\u00b73%) of 2573 patients in primary care and 371 (5\u00b77%) of 6494 patients admitted to hospital were infected with a seasonal hCoV. OC43 was the seasonal hCoV with the highest prevalence across age groups and highest incidence in children admitted to hospital who were younger than 5 years (incidence 9\u00b70 [95% CI 7\u00b72-11\u00b72] per 100 000 person-months) and adults older than 65 years (2\u00b76 [2\u00b71-3\u00b72] per 100 000 person-months). Among 262 patients admitted to hospital with seasonal hCoV infection and with complete information on potential risk factors, 66 (73\u00b73%) of 90 patients who had complications or died also had at least one potential risk factor (p=0\u00b70064). Complications in children younger than 5 years were associated with co-infection (24 [36\u00b74%] of 66; p=0\u00b7017), and in teenagers and adults (\u226515 years), more complications arose in patients with a single hCoV infection (49 [45\u00b70%] of 109; p=0\u00b70097). In early 2020, the Belgian SARI surveillance detected the first SARS-CoV-2-positive sample concomitantly with the first confirmed COVID-19 case with no travel history to China.\r\n\r\nThe main burden of severe seasonal hCoV infection lies with children younger than 5 years with co-infections and adults aged 65 years and older with pre-existing comorbidities. These age and patient groups should be targeted for enhanced observation when in medical care and in possible future vaccination strategies, and co-infections in children younger than 5 years should be considered during diagnosis and treatment. Our findings support the use of national influenza surveillance systems for seasonal hCoV monitoring and early detection, and monitoring of emerging coronaviruses such as SARS-CoV-2.\r\n\r\nBelgian Federal Public Service Health, Food Chain Safety, and Environment; Belgian National Insurance Health Care (Institut national d'assurance maladie-invalidit\u00e9/Rijksinstituut voor ziekte-en invaliditeitsverzekering); and Regional Health Authorities (Flanders Agentschap zorg en gezondheid, Brussels Commission communautaire commune, Wallonia Agence pour une vie de qualit\u00e9).", "doi": "10.1016/s2666-5247(20)30221-4", "pmid": "33937883", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-05-04T15:57:48.285Z", "modified": "2021-06-18T14:46:29.690Z"}, {"entity": "publication", "iuid": "101f86cc435f4e869f06e10bc5689df5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/101f86cc435f4e869f06e10bc5689df5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/101f86cc435f4e869f06e10bc5689df5"}}, "title": "Interactions between seasonal human coronaviruses and implications for the SARS-CoV-2 pandemic: A retrospective study in Stockholm, Sweden, 2009-2020.", "authors": [{"family": "Dyrdak", "given": "Robert", "initials": "R", "orcid": "0000-0001-8456-4898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98ad76a0e144478cb3ceabd05c9928b0.json"}}, {"family": "Hodcroft", "given": "Emma B", "initials": "EB", "orcid": "0000-0002-0078-2212", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/563993c9fb68466c8867ca7600733548.json"}}, {"family": "Wahlund", "given": "Martina", "initials": "M"}, {"family": "Neher", "given": "Richard A", "initials": "RA", "orcid": "0000-0003-2525-1407", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a31564f19214fbdb275578ed05a6bcb.json"}}, {"family": "Albert", "given": "Jan", "initials": "J", "orcid": "0000-0001-9020-0521", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79a6c7eedadb4a1e8c6fd7b8b522a8e3.json"}}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "J Clin Virol", "issn": "1873-5967", "volume": "136", "issue": null, "pages": "104754", "issn-l": null}, "abstract": "The four seasonal coronaviruses 229E, NL63, OC43, and HKU1 are frequent causes of respiratory infections and show annual and seasonal variation. Increased understanding about these patterns could be informative about the epidemiology of SARS-CoV-2.\n\nResults from PCR diagnostics for the seasonal coronaviruses, and other respiratory viruses, were obtained for 55,190 clinical samples analyzed at the Karolinska University Hospital, Stockholm, Sweden, between 14 September 2009 and 2 April 2020.\n\nSeasonal coronaviruses were detected in 2130 samples (3.9 %) and constituted 8.1 % of all virus detections. OC43 was most commonly detected (28.4 % of detections), followed by NL63 (24.0 %), HKU1 (17.6 %), and 229E (15.3 %). The overall fraction of positive samples was similar between seasons, but at species level there were distinct biennial alternating peak seasons for the Alphacoronaviruses, 229E and NL63, and the Betacoronaviruses, OC43 and HKU1, respectively. The Betacoronaviruses peaked earlier in the winter season (Dec-Jan) than the Alphacoronaviruses (Feb-Mar). Coronaviruses were detected across all ages, but diagnostics were more frequently requested for paediatric patients than adults and the elderly. OC43 and 229E incidence was relatively constant across age strata, while that of NL63 and HKU1 decreased with age.\n\nBoth the Alphacoronaviruses and Betacoronaviruses showed alternating biennial winter incidence peaks, which suggests some type of immune mediated interaction. Symptomatic reinfections in adults and the elderly appear relatively common. Both findings may be of relevance for the epidemiology of SARS-CoV-2.", "doi": "10.1016/j.jcv.2021.104754", "pmid": "33601153", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pmc", "key": "PMC7869750"}, {"db": "pii", "key": "S1386-6532(21)00021-4"}], "notes": [], "created": "2021-02-19T14:05:54.744Z", "modified": "2023-06-19T14:44:22.357Z"}, {"entity": "publication", "iuid": "7d04c0dd10e84d5a812d21d4b41b5fd2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d04c0dd10e84d5a812d21d4b41b5fd2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d04c0dd10e84d5a812d21d4b41b5fd2"}}, "title": "Global Tuberculosis Report 2020 \u2013 Reflections on the Global TB burden, treatment and prevention efforts", "authors": [{"family": "Chakaya", "given": "Jeremiah", "initials": "J"}, {"family": "Khan", "given": "Mishal", "initials": "M"}, {"family": "Ntoumi", "given": "Francine", "initials": "F"}, {"family": "Aklillu", "given": "Eleni", "initials": "E"}, {"family": "Fatima", "given": "Razia", "initials": "R"}, {"family": "Mwaba", "given": "Peter", "initials": "P"}, {"family": "Kapata", "given": "Nathan", "initials": "N"}, {"family": "Mfinanga", "given": "Sayoki", "initials": "S"}, {"family": "Hasnain", "given": "Seyed Ehtesham", "initials": "SE"}, {"family": "Katoto", "given": "Patrick D M C", "initials": "PDMC"}, {"family": "Bulabula", "given": "Andr\u00e9 N H", "initials": "ANH"}, {"family": "Sam-Agudu", "given": "Nadia A", "initials": "NA"}, {"family": "Nachega", "given": "Jean B", "initials": "JB"}, {"family": "Tiberi", "given": "Simon", "initials": "S"}, {"family": "McHugh", "given": "Timothy D", "initials": "TD"}, {"family": "Abubakar", "given": "Ibrahim", "initials": "I"}, {"family": "Zumla", "given": "Alimuddin", "initials": "A"}], "type": "journal-article", "published": "2021-03-00", "journal": {"title": "Int J Infect Dis", "issn": "1201-9712", "volume": null, "issue": null, "issn-l": null}, "abstract": "The October 2020 Global TB report reviews TB control strategies and United Nations (UN) targets set in the political declaration at the September 2018 UN General Assembly high-level meeting on TB held in New York. Progress in TB care and prevention has been very slow. In 2019, TB remained the most common cause of death from a single infectious pathogen. Globally, an estimated 10.0 million people developed TB disease in 2019, and there were an estimated 1.2 million TB deaths among HIV-negative people and an additional 208, 000 deaths among people living with HIV. Adults accounted for 88% and children for 12% of people with TB. The WHO regions of South-East Asia (44%), Africa (25%), and the Western Pacific (18%) had the most people with TB. Eight countries accounted for two thirds of the global total: India (26%), Indonesia (8.5%), China (8.4%), the Philippines (6.0%), Pakistan (5.7%), Nigeria (4.4%), Bangladesh (3.6%) and South Africa (3.6%). Only 30% of the 3.5 million five-year target for children treated for TB was met. Major advances have been development of new all oral regimens for MDRTB and new regimens for preventive therapy. In 2020, the COVID-19 pandemic dislodged TB from the top infectious disease cause of mortality globally. Notably, global TB control efforts were not on track even before the advent of the COVID-19 pandemic. Many challenges remain to improve sub-optimal TB treatment and prevention services. Tuberculosis screening and diagnostic test services need to be ramped up. The major drivers of TB remain undernutrition, poverty, diabetes, tobacco smoking, and household air pollution and these need be addressed to achieve the WHO 2035 TB care and prevention targets. National programs need to include interventions for post-tuberculosis holistic wellbeing. From first detection of COVID-19 global coordination and political will with huge financial investments have led to the development of effective vaccines against SARS-CoV2 infection. The world now needs to similarly focus on development of new vaccines for TB utilizing new technological methods.", "doi": "10.1016/j.ijid.2021.02.107", "pmid": "33716195", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)00193-4"}], "notes": [], "created": "2021-03-17T07:44:20.760Z", "modified": "2021-11-18T12:57:11.611Z"}, {"entity": "publication", "iuid": "32060e12cef54c949408c3780679c265", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/32060e12cef54c949408c3780679c265.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/32060e12cef54c949408c3780679c265"}}, "title": "Emerging COVID-19 impacts, responses, and lessons for building resilience in the seafood system.", "authors": [{"family": "Love", "given": "David C", "initials": "DC"}, {"family": "Allison", "given": "Edward H", "initials": "EH"}, {"family": "Asche", "given": "Frank", "initials": "F"}, {"family": "Belton", "given": "Ben", "initials": "B"}, {"family": "Cottrell", "given": "Richard S", "initials": "RS"}, {"family": "Froehlich", "given": "Halley E", "initials": "HE"}, {"family": "Gephart", "given": "Jessica A", "initials": "JA"}, {"family": "Hicks", "given": "Christina C", "initials": "CC"}, {"family": "Little", "given": "David C", "initials": "DC"}, {"family": "Nussbaumer", "given": "Elizabeth M", "initials": "EM"}, {"family": "Pinto da Silva", "given": "Patricia", "initials": "P"}, {"family": "Poulain", "given": "Florence", "initials": "F"}, {"family": "Rubio", "given": "Angel", "initials": "A"}, {"family": "Stoll", "given": "Joshua S", "initials": "JS"}, {"family": "Tlusty", "given": "Michael F", "initials": "MF"}, {"family": "Thorne-Lyman", "given": "Andrew L", "initials": "AL"}, {"family": "Troell", "given": "Max", "initials": "M"}, {"family": "Zhang", "given": "Wenbo", "initials": "W"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Glob Food Sec", "issn": "2211-9124", "volume": "28", "pages": "100494", "issn-l": null}, "abstract": "The COVID-19 pandemic and subsequent lockdowns are creating health and economic crises that threaten food and nutrition security. The seafood sector provides important sources of nutrition and employment, especially in low-income countries, and is highly globalized allowing shocks to propagate. We studied COVID-19-related disruptions, impacts, and responses to the seafood sector from January through May 2020, using a food system resilience 'action cycle' framework as a guide. We find that some supply chains, market segments, companies, small-scale actors and civil society have shown initial signs of greater resilience than others. COVID-19 has also highlighted the vulnerability of certain groups working in- or dependent on the seafood sector. We discuss early coping and adaptive responses combined with lessons from past shocks that could be considered when building resilience in the sector. We end with strategic research needs to support learning from COVID-19 impacts and responses.", "doi": "10.1016/j.gfs.2021.100494", "pmid": "34513582", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2211-9124(21)00004-3"}, {"db": "pmc", "key": "PMC8417121"}], "notes": [], "created": "2021-09-20T06:33:28.865Z", "modified": "2021-09-20T06:33:28.892Z"}, {"entity": "publication", "iuid": "9931f188999f44fba834cbe17b7ac2d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9931f188999f44fba834cbe17b7ac2d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9931f188999f44fba834cbe17b7ac2d9"}}, "title": "COVID-19: cross-border contact tracing in Germany, February to April 2020.", "authors": [{"family": "Markus", "given": "Inessa", "initials": "I"}, {"family": "Steffen", "given": "Gyde", "initials": "G"}, {"family": "Lachmann", "given": "Raskit", "initials": "R"}, {"family": "Marquis", "given": "Adine", "initials": "A"}, {"family": "Schneider", "given": "Timm", "initials": "T"}, {"family": "Tomczyk", "given": "Sara", "initials": "S"}, {"family": "Koppe", "given": "Uwe", "initials": "U"}, {"family": "Rohde", "given": "Anna M", "initials": "AM"}, {"family": "Schink", "given": "Susanne Barbara", "initials": "SB"}, {"family": "Seifried", "given": "Janna", "initials": "J"}, {"family": "Domaszewska", "given": "Teresa", "initials": "T"}, {"family": "Rexroth", "given": "Ute", "initials": "U"}, {"family": "An der Heiden", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "10", "pages": null}, "abstract": "IntroductionThe Robert Koch Institute (RKI) managed the exchange of cross-border contact tracing data between public health authorities (PHA) in Germany and abroad during the early COVID-19 pandemic.AimWe describe the extent of cross-border contact tracing and its challenges.MethodsWe analysed cross-border COVID-19 contact tracing events from 3 February to 5 April 2020 using information exchanged through the European Early Warning Response System and communication with International Health Regulation national focal points. We described events by PHA, number of contacts and exposure context.ResultsThe RKI processed 467 events, initiating contact to PHA 1,099 times (median = 1; interquartile range (IQR): 1-2) and sharing data on 5,099 contact persons. Of 327 (70%) events with known exposure context, the most commonly reported exposures were aircraft (n = 64; 20%), cruise ships (n = 24; 7%) and non-transport contexts (n = 210; 64%). Cruise ship and aircraft exposures generated more contacts with authorities (median = 10; IQR: 2-16, median = 4; IQR: 2-11) and more contact persons (median = 60; IQR: 9-269, median = 2; IQR: 1-3) than non-transport exposures (median = 1; IQR: 1-6 and median = 1; IQR: 1-2). The median time spent on contact tracing was highest for cruise ships: 5 days (IQR: 3-9).ConclusionIn the COVID-19 pandemic, cross-border contact tracing is considered a critical component of the outbreak response. While only a minority of international contact tracing activities were related to exposure events in transport, they contributed substantially to the workload. The numerous communications highlight the need for fast and efficient global outbreak communication channels between PHA.", "doi": "10.2807/1560-7917.ES.2021.26.10.2001236", "pmid": "33706859", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-17T07:08:26.792Z", "modified": "2021-06-18T14:35:54.846Z"}, {"entity": "publication", "iuid": "fa577d8d62b147619aef4361d53d40ea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa577d8d62b147619aef4361d53d40ea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa577d8d62b147619aef4361d53d40ea"}}, "title": "ARIA-EAACI statement on asthma and COVID-19 (June 2, 2020).", "authors": [{"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Jutel", "given": "Marek", "initials": "M"}, {"family": "Akdis", "given": "Cezmi A", "initials": "CA", "orcid": "0000-0001-8020-019X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1c16696cf404e6ebd2a06c63b8d9849.json"}}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Pfaar", "given": "Oliver", "initials": "O", "orcid": "0000-0003-4374-9639", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0b23ecb478474bd18839b7ecaced7f08.json"}}, {"family": "Nadeau", "given": "Kari C", "initials": "KC", "orcid": "0000-0002-2146-2955", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/23da79d94ab448f49859abb68f851e31.json"}}, {"family": "Eiwegger", "given": "Thomas", "initials": "T", "orcid": "0000-0002-2914-7829", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c90e67dd0a5451a9c95ea4570834cb9.json"}}, {"family": "Bedbrook", "given": "Anna", "initials": "A"}, {"family": "Ansotegui", "given": "Ignacio J", "initials": "IJ"}, {"family": "Anto", "given": "Josep M", "initials": "JM"}, {"family": "Bachert", "given": "Claus", "initials": "C", "orcid": "0000-0003-4742-1665", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac2485abcc7646aebe7330c514b47c29.json"}}, {"family": "Bateman", "given": "Eric D", "initials": "ED"}, {"family": "Bennoor", "given": "Kazi S", "initials": "KS"}, {"family": "Berghea", "given": "Elena Camelia", "initials": "EC"}, {"family": "Bergmann", "given": "Karl-Christian", "initials": "KC", "orcid": "0000-0002-0306-9922", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f09bd15c861743a7851bde407356fb6b.json"}}, {"family": "Blain", "given": "Hubert", "initials": "H"}, {"family": "Bonini", "given": "Mateo", "initials": "M", "orcid": "0000-0002-3042-0765", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb9057d6fa3d4f4ea86351af45ce21bc.json"}}, {"family": "Bosnic-Anticevich", "given": "Sinthia", "initials": "S"}, {"family": "Boulet", "given": "Louis-Philippe", "initials": "LP", "orcid": "0000-0003-3485-9393", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/997f95adb7f34198a9c837217332fae2.json"}}, {"family": "Brussino", "given": "Luisa", "initials": "L"}, {"family": "Buhl", "given": "Roland", "initials": "R"}, {"family": "Camargos", "given": "Paulo", "initials": "P"}, {"family": "Canonica", "given": "Giorgio Walter", "initials": "GW"}, {"family": "Cardona", "given": "Victoria", "initials": "V", "orcid": "0000-0003-2197-9767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/80cffee5190f476d99c541a2282fd0d4.json"}}, {"family": "Casale", "given": "Thomas", "initials": "T", "orcid": "0000-0002-3149-7377", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba9ce0f5cdc4473395b7f0991abdc9ba.json"}}, {"family": "Chinthrajah", "given": "Sharon", "initials": "S"}, {"family": "Akdis", "given": "M\u00fcbeccel", "initials": "M", "orcid": "0000-0003-0554-9943", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b3e08fc9040548058d7c21f7b3931dbe.json"}}, {"family": "Chivato", "given": "Tomas", "initials": "T"}, {"family": "Christoff", "given": "George", "initials": "G"}, {"family": "Cruz", "given": "Alvaro A", "initials": "AA", "orcid": "0000-0002-7403-3871", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/befa954a45424a7ea1b84e55e9bcdccb.json"}}, {"family": "Czarlewski", "given": "Wienczyslawa", "initials": "W"}, {"family": "Del Giacco", "given": "Stefano", "initials": "S"}, {"family": "Du", "given": "Hui", "initials": "H"}, {"family": "El-Gamal", "given": "Yehia", "initials": "Y"}, {"family": "Fokkens", "given": "Wytske J", "initials": "WJ", "orcid": "0000-0003-4852-229X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c1a5bcdc04b0454392dbb1c6a9c003cf.json"}}, {"family": "Fonseca", "given": "Joao A", "initials": "JA"}, {"family": "Gao", "given": "Yadong", "initials": "Y"}, {"family": "Gaga", "given": "Mina", "initials": "M"}, {"family": "Gemicioglu", "given": "Bilun", "initials": "B"}, {"family": "Gotua", "given": "Maia", "initials": "M", "orcid": "0000-0003-2497-4128", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb1141c3d0e14b53a4c2dce6166d634a.json"}}, {"family": "Haahtela", "given": "Tari", "initials": "T", "orcid": "0000-0003-4757-2156", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/339da718bfb24a95b2920bc60429c314.json"}}, {"family": "Halpin", "given": "David", "initials": "D"}, {"family": "Hamelmann", "given": "Eckard", "initials": "E", "orcid": "0000-0002-2996-8248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e21761fe26845dbaa8d962408ad97ff.json"}}, {"family": "Hoffmann-Sommergruber", "given": "Karin", "initials": "K"}, {"family": "Humbert", "given": "Marc", "initials": "M"}, {"family": "Ilina", "given": "Nataliya", "initials": "N"}, {"family": "Ivancevich", "given": "Juan-Carlos", "initials": "JC"}, {"family": "Joos", "given": "Guy", "initials": "G"}, {"family": "Khaitov", "given": "Musa", "initials": "M"}, {"family": "Kirenga", "given": "Bruce", "initials": "B"}, {"family": "Knol", "given": "Edward F", "initials": "EF"}, {"family": "Ko", "given": "Fanny W", "initials": "FW"}, {"family": "Koskinen", "given": "Seppo", "initials": "S"}, {"family": "Kowalski", "given": "Marek L", "initials": "ML"}, {"family": "Kraxner", "given": "Helga", "initials": "H"}, {"family": "Kudlay", "given": "Dmitry", "initials": "D", "orcid": "0000-0003-1878-4467", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d3e6e559aae24655870f855046230f21.json"}}, {"family": "Kuna", "given": "Piotr", "initials": "P"}, {"family": "Kupczyk", "given": "Maciej", "initials": "M"}, {"family": "Kvedariene", "given": "Violeta", "initials": "V"}, {"family": "Abdul Latiff", "given": "Amir H", "initials": "AH"}, {"family": "Le", "given": "Lan T", "initials": "LT"}, {"family": "Levin", "given": "Michael", "initials": "M", "orcid": "0000-0003-2439-7981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/56d68a2cbab745dd8745c99e6acea42f.json"}}, {"family": "Larenas-Linnemann", "given": "Desiree", "initials": "D", "orcid": "0000-0002-5713-5331", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b8ffe8940cf9462e86211ff56b10528f.json"}}, {"family": "Louis", "given": "Renaud", "initials": "R"}, {"family": "Masjedi", "given": "Mohammad R", "initials": "MR"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Mihaltan", "given": "Florin", "initials": "F"}, {"family": "Milenkovic", "given": "Branislava", "initials": "B"}, {"family": "Mohammad", "given": "Yousser", "initials": "Y"}, {"family": "Morais-Almeida", "given": "Mario", "initials": "M", "orcid": "0000-0003-1837-2980", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/642d46cfd0f54668a32f1baab68ba33d.json"}}, {"family": "Mullol", "given": "Joaquim", "initials": "J"}, {"family": "Namazova", "given": "Leyla", "initials": "L"}, {"family": "Neffen", "given": "Hugo", "initials": "H"}, {"family": "Nunes", "given": "Elisabete", "initials": "E"}, {"family": "O'Byrne", "given": "Paul", "initials": "P"}, {"family": "O'Hehir", "given": "Robyn", "initials": "R"}, {"family": "O'Mahony", "given": "Liam", "initials": "L"}, {"family": "Ohta", "given": "Ken", "initials": "K", "orcid": "0000-0001-9734-4579", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/465a0478a3b047ae8d6845f61380256d.json"}}, {"family": "Okamoto", "given": "Yoshitaka", "initials": "Y"}, {"family": "Onorato", "given": "Gabrielle L", "initials": "GL"}, {"family": "Panzner", "given": "Petr", "initials": "P"}, {"family": "Papadopoulos", "given": "Nikos G", "initials": "NG", "orcid": "0000-0002-4448-3468", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c15c79dff08b458fa296e513201635be.json"}}, {"family": "Passalacqua", "given": "Gianni", "initials": "G", "orcid": "0000-0002-5139-3604", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1a7d959168ef499a8f2a2b576de11ad0.json"}}, {"family": "Patella", "given": "Vincenzo", "initials": "V", "orcid": "0000-0001-5640-6446", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/decdadd477b4440695714b4a9bbf609a.json"}}, {"family": "Pawankar", "given": "Ruby", "initials": "R"}, {"family": "Pham-Thi", "given": "Nh\u00e2n", "initials": "N"}, {"family": "Pigearias", "given": "Bernard", "initials": "B"}, {"family": "Popov", "given": "Todor A", "initials": "TA"}, {"family": "Puggioni", "given": "Francesca", "initials": "F"}, {"family": "Regateiro", "given": "Frederico S", "initials": "FS"}, {"family": "Rolla", "given": "Giovanni", "initials": "G"}, {"family": "Rottem", "given": "Menachem", "initials": "M"}, {"family": "Samolinski", "given": "Boleslaw", "initials": "B"}, {"family": "Sastre", "given": "Joaquin", "initials": "J", "orcid": "0000-0003-4689-6837", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/03ef6cc3dbfb4764905e593f210e7759.json"}}, {"family": "Schwarze", "given": "Jurgen", "initials": "J"}, {"family": "Sheikh", "given": "Aziz", "initials": "A"}, {"family": "Scichilone", "given": "Nicola", "initials": "N"}, {"family": "Soto-Quiros", "given": "Manuel", "initials": "M"}, {"family": "Soto-Martinez", "given": "Manuel", "initials": "M"}, {"family": "Sova", "given": "Milan", "initials": "M"}, {"family": "Nicola", "given": "Stefania", "initials": "S"}, {"family": "Stelmach", "given": "Rafael", "initials": "R"}, {"family": "Suppli-Ulrik", "given": "Charlotte", "initials": "C"}, {"family": "Taborda-Barata", "given": "Luis", "initials": "L"}, {"family": "To", "given": "Teresa", "initials": "T"}, {"family": "Tomazic", "given": "Peter-Valentin", "initials": "PV", "orcid": "0000-0001-6445-4800", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e57596e0a1974baf85e37fcf8195f7b9.json"}}, {"family": "Toppila-Salmi", "given": "Sanna", "initials": "S", "orcid": "0000-0003-0890-6686", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8d947e332e4341309f076161a3052a9d.json"}}, {"family": "Tsiligianni", "given": "Ioanna", "initials": "I"}, {"family": "Usmani", "given": "Omar", "initials": "O"}, {"family": "Valiulis", "given": "Arunas", "initials": "A"}, {"family": "Ventura", "given": "Maria Teresa", "initials": "MT"}, {"family": "Viegi", "given": "Giovanni", "initials": "G"}, {"family": "Vontetsianos", "given": "Theodor", "initials": "T"}, {"family": "Wang", "given": "De Yun", "initials": "Y"}, {"family": "Williams", "given": "Sian", "initials": "S"}, {"family": "Wong", "given": "Gary W K", "initials": "GWK", "orcid": "0000-0001-5939-812X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a7be3acc778435bb925e8c671876b8c.json"}}, {"family": "Yorgancioglu", "given": "Arzu", "initials": "A"}, {"family": "Zernotti", "given": "Mario", "initials": "M"}, {"family": "Zidarn", "given": "Mihaela", "initials": "M"}, {"family": "Zuberbier", "given": "Torsten", "initials": "T", "orcid": "0000-0002-1466-8875", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7dc091f64a240fd8fb6443292b812c6.json"}}, {"family": "Agache", "given": "Ioana", "initials": "I", "orcid": "0000-0001-7994-364X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25d9598f74414a38a868c2bcf545e94d.json"}}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": "76", "issue": "3", "pages": "689-697", "issn-l": "0105-4538"}, "abstract": null, "doi": "10.1111/all.14471", "pmid": "32588922", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7361514"}], "notes": [], "created": "2020-12-08T15:47:32.488Z", "modified": "2023-06-19T14:56:33.583Z"}, {"entity": "publication", "iuid": "fbd0f47a2fe447f4bbadac01d12693b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fbd0f47a2fe447f4bbadac01d12693b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fbd0f47a2fe447f4bbadac01d12693b1"}}, "title": "Racial and ethnic differences in COVID-19 vaccine hesitancy and uptake", "authors": [{"family": "Nguyen", "given": "Long H", "initials": "LH"}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Merino", "given": "Jordi", "initials": "J"}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Lo", "given": "Chun Han", "initials": "CH"}, {"family": "Kwon", "given": "Sohee", "initials": "S"}, {"family": "Wang", "given": "Kai", "initials": "K"}, {"family": "Graham", "given": "Mark S", "initials": "MS"}, {"family": "Polidori", "given": "Lorenzo", "initials": "L"}, {"family": "Menni", "given": "Cristina", "initials": "C"}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Anyane-Yeboa", "given": "Adjoa", "initials": "A"}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Warner", "given": "Erica T", "initials": "ET"}, {"family": "Hu", "given": "Christina Y", "initials": "CY"}, {"family": "Selvachandran", "given": "Somesh", "initials": "S"}, {"family": "Davies", "given": "Richard", "initials": "R"}, {"family": "Nash", "given": "Denis", "initials": "D"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Spector", "given": "Tim D", "initials": "TD"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}], "type": "posted-content", "published": "2021-02-28", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.25.21252402", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-10T15:04:30.526Z", "modified": "2021-03-12T10:08:58.796Z"}, {"entity": "publication", "iuid": "abda60f2e6fa4991907b165c02f376c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abda60f2e6fa4991907b165c02f376c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abda60f2e6fa4991907b165c02f376c5"}}, "title": "Changes of Gambling Patterns during COVID-19 in Sweden, and Potential for Preventive Policy Changes. A Second Look Nine Months into the Pandemic.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "Widinghoff", "given": "Carolina", "initials": "C"}], "type": "journal article", "published": "2021-02-27", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "5", "pages": null}, "abstract": "Gambling has been suggested as one of the potential mental health consequences of the COVID-19 pandemic. In earlier self-report studies, increased gambling has been reported by a limited proportion of respondents characterized with a high degree of problem gambling. The present study, carried out with the same methodology and in the same geographical setting, around seven months later in the pandemic, aimed to repeat and to extend the understanding of potential gambling changes in the population during COVID-19. An anonymous sample of web panel members was assessed, altogether 2029 individuals (52% women, 10% moderate-risk or problem gamblers). Results indicated that 6% reported increased gambling, and 4% reported decreased gambling during the pandemic. Having increased gambling was associated with more severe gambling problems (OR 2.78, 95% confidence interval 2.27-3.40), increased alcohol consumption (OR 2.92, 1.71-4.98), and psychological distress (OR 3.38, 1.83-6.23). In the group reporting increased gambling during COVID-19, moderate-risk/problem gambling was very common (62%). Recent governmental policy interventions in the area were known to a minority (30%) of respondents, but awareness of the regulations was markedly more common in individuals with at least moderate-risk gambling (56%) and in self-excluders (78%). Reporting of any perceived influence from policy changes was low (3%), and divided between those reporting an increasing and decreasing effect, respectively. Increased gambling may be a consequence of COVID-19-related changes in everyday lives of individuals with problematic gambling patterns. Thus, a vulnerable group demonstrates higher rates of gambling migration and psychosocial problems, and may require particular attention in screening and treatment contexts, and further scientific evaluations.", "doi": "10.3390/ijerph18052342", "pmid": "33673575", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph18052342"}], "notes": [], "created": "2021-03-08T10:53:43.655Z", "modified": "2021-06-18T14:31:03.572Z"}, {"entity": "publication", "iuid": "5d070ba5bf81463dbb738f0abdd09039", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5d070ba5bf81463dbb738f0abdd09039.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5d070ba5bf81463dbb738f0abdd09039"}}, "title": "COVID-19 Vaccines: Global Challenges and Prospects Forum Recommendations.", "authors": [{"family": "Boudjelal", "given": "Mohamed", "initials": "M"}, {"family": "Almajed", "given": "Faisal", "initials": "F"}, {"family": "Salman", "given": "Ahmed M", "initials": "AM"}, {"family": "Alharbi", "given": "Naif K", "initials": "NK"}, {"family": "Colangelo", "given": "Margaretta", "initials": "M"}, {"family": "Michelotti", "given": "Julia M", "initials": "JM"}, {"family": "Olinger", "given": "Gene", "initials": "G"}, {"family": "Baker", "given": "Mariwan", "initials": "M"}, {"family": "Hill", "given": "Adrian V S", "initials": "AVS"}, {"family": "Alaskar", "given": "Ahmed", "initials": "A"}], "type": "journal article", "published": "2021-02-27", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "volume": null, "issue": null, "issn-l": "1201-9712"}, "abstract": "Perspective On November 4 and 5, 2020 the 11 th Annual KAIMRC Global Forum was organized as a G20 related event entitled COVID-19 Vaccines: Global Challenges and Prospects, https://globalcovid19vaccines.com. It was a vital event that provided a hub for leading COVID-19 scientists, regulators, pharmaceutical representative, funders and charities to learn about COVID-19 vaccines in development, discuss different vaccine candidates, make recommendations, highlight lessons learned and address appropriate plans for global distribution and pricing. Over 10,000 people from 94 countries attended the forum. The leading COVID-19 vaccines presented use different technologies including: (a) Non-replicating viral vector based vaccines, ChAdOx1 nCoV-19/AZD1222 vaccine developed by Oxford-AstraZeneca (van Doremalen et al., 2020), the Sputnik V developed by the Russian Gamaleya Institute consisting of two components, a recombinant adenovirus type 26 (rAd26) vector and a recombinant adenovirus type 5 (rAd5) vector (Logunov et al., 2020), and the Ad26.COV2.S developed by Center for Virology and Vaccine Research, at Harvard Medical School in collaboration with Janssen Vaccines and Prevention BV, Leiden (Mercado et al., 2020). (b) Nucleic Acid, DNA- or RNA- based Vaccines that include the mRNA-1273 vaccine that is being developed by Moderna (Anderson et al., 2020), and a self-amplifying (saRNA) vaccine termed VGHsa111 developed by Imperial College, London as well as another co-developed by Pfizer and Biontech. An example of a DNA based vaccine against COVID19 is INO-4800 that is being developed by Inovio Pharmaceuticals Inc. (Smith et al., 2020). (c) Protein based vaccines, CoV RBD219-N1 Vaccine from Baylor College of Medicine, Texas that is based on a yeast-derived (Pichia pastoris) protein (Hotez and Bottazzi, 2020) and from Anhui Zhifei Longcom Biopharmaceutical Co. Ltd (Dai et al., 2020). Representatives from the Bill & Melinda Gates Foundation, the Bring Hope Humanitarian Foundation (BHHF), and the Coalition for Epidemic Preparedness Innovations (CEPI), presented their plans for distributing the vaccines to people in need around the world including the low-income countries. They are also developing educational programs to train health workers in immunization procedures.", "doi": "10.1016/j.ijid.2021.02.093", "pmid": "33652065", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)00179-X"}], "notes": [], "created": "2021-03-03T17:01:09.572Z", "modified": "2021-03-03T17:01:09.582Z"}, {"entity": "publication", "iuid": "3d00241e04a747daba93735a14a4a98a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3d00241e04a747daba93735a14a4a98a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3d00241e04a747daba93735a14a4a98a"}}, "title": "In silico Analyses of Immune System Protein Interactome Network, Single-Cell RNA Sequencing of Human Tissues, and Artificial Neural Networks Reveal Potential Therapeutic Targets for Drug Repurposing Against COVID-19.", "authors": [{"family": "L\u00f3pez-Cort\u00e9s", "given": "Andr\u00e9s", "initials": "A"}, {"family": "Guevara-Ram\u00edrez", "given": "Patricia", "initials": "P"}, {"family": "Kyriakidis", "given": "Nikolaos C", "initials": "NC"}, {"family": "Barba-Ostria", "given": "Carlos", "initials": "C"}, {"family": "Le\u00f3n C\u00e1ceres", "given": "\u00c1ngela", "initials": "\u00c1"}, {"family": "Guerrero", "given": "Santiago", "initials": "S"}, {"family": "Ortiz-Prado", "given": "Esteban", "initials": "E"}, {"family": "Munteanu", "given": "Cristian R", "initials": "CR"}, {"family": "Tejera", "given": "Eduardo", "initials": "E"}, {"family": "Cevallos-Robalino", "given": "Dom\u00e9nica", "initials": "D"}, {"family": "G\u00f3mez-Jaramillo", "given": "Ana Mar\u00eda", "initials": "AM"}, {"family": "Simba\u00f1a-Rivera", "given": "Katherine", "initials": "K"}, {"family": "Granizo-Mart\u00ednez", "given": "Adriana", "initials": "A"}, {"family": "P\u00e9rez-M", "given": "Gabriela", "initials": "G"}, {"family": "Moreno", "given": "Silvana", "initials": "S"}, {"family": "Garc\u00eda-C\u00e1rdenas", "given": "Jennyfer M", "initials": "JM"}, {"family": "Zambrano", "given": "Ana Karina", "initials": "AK"}, {"family": "P\u00e9rez-Castillo", "given": "Yunierkis", "initials": "Y"}, {"family": "Cabrera-Andrade", "given": "Alejandro", "initials": "A"}, {"family": "Puig San Andr\u00e9s", "given": "Lourdes", "initials": "L"}, {"family": "Proa\u00f1o-Castro", "given": "Carolina", "initials": "C"}, {"family": "Bautista", "given": "Jhommara", "initials": "J"}, {"family": "Quevedo", "given": "Andreina", "initials": "A"}, {"family": "Varela", "given": "Nelson", "initials": "N"}, {"family": "Qui\u00f1ones", "given": "Luis Abel", "initials": "LA"}, {"family": "Paz-Y-Mi\u00f1o", "given": "C\u00e9sar", "initials": "C"}], "type": "journal article", "published": "2021-02-26", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "12", "issue": null, "pages": "598925", "issn-l": "1663-9812"}, "abstract": "Background: There is pressing urgency to identify therapeutic targets and drugs that allow treating COVID-19 patients effectively. Methods: We performed in silico analyses of immune system protein interactome network, single-cell RNA sequencing of human tissues, and artificial neural networks to reveal potential therapeutic targets for drug repurposing against COVID-19. Results: We screened 1,584 high-confidence immune system proteins in ACE2 and TMPRSS2 co-expressing cells, finding 25 potential therapeutic targets significantly overexpressed in nasal goblet secretory cells, lung type II pneumocytes, and ileal absorptive enterocytes of patients with several immunopathologies. Then, we performed fully connected deep neural networks to find the best multitask classification model to predict the activity of 10,672 drugs, obtaining several approved drugs, compounds under investigation, and experimental compounds with the highest area under the receiver operating characteristics. Conclusion: After being effectively analyzed in clinical trials, these drugs can be considered for treatment of severe COVID-19 patients. Scripts can be downloaded at https://github.com/muntisa/immuno-drug-repurposing-COVID-19.", "doi": "10.3389/fphar.2021.598925", "pmid": "33716737", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "598925"}, {"db": "pmc", "key": "PMC7952300"}], "notes": [], "created": "2021-03-17T07:46:57.745Z", "modified": "2021-03-22T11:40:39.483Z"}, {"entity": "publication", "iuid": "42cbde64f28a462e8b59f47ad4eebf6d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/42cbde64f28a462e8b59f47ad4eebf6d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/42cbde64f28a462e8b59f47ad4eebf6d"}}, "title": "Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19: A Systematic Review and Meta-analysis.", "authors": [{"family": "Janiaud", "given": "Perrine", "initials": "P"}, {"family": "Axfors", "given": "Cathrine", "initials": "C"}, {"family": "Schmitt", "given": "Andreas M", "initials": "AM"}, {"family": "Gloy", "given": "Viktoria", "initials": "V"}, {"family": "Ebrahimi", "given": "Fahim", "initials": "F"}, {"family": "Hepprich", "given": "Matthias", "initials": "M"}, {"family": "Smith", "given": "Emily R", "initials": "ER"}, {"family": "Haber", "given": "Noah A", "initials": "NA"}, {"family": "Khanna", "given": "Nina", "initials": "N"}, {"family": "Moher", "given": "David", "initials": "D"}, {"family": "Goodman", "given": "Steven N", "initials": "SN"}, {"family": "Ioannidis", "given": "John P A", "initials": "JPA"}, {"family": "Hemkens", "given": "Lars G", "initials": "LG"}], "type": "journal article", "published": "2021-02-26", "journal": {"title": "JAMA", "issn": "1538-3598", "volume": null, "issue": null, "issn-l": "0098-7484"}, "abstract": "Convalescent plasma is a proposed treatment for COVID-19.\n\nTo assess clinical outcomes with convalescent plasma treatment vs placebo or standard of care in peer-reviewed and preprint publications or press releases of randomized clinical trials (RCTs).\n\nPubMed, the Cochrane COVID-19 trial registry, and the Living Overview of Evidence platform were searched until January 29, 2021.\n\nThe RCTs selected compared any type of convalescent plasma vs placebo or standard of care for patients with confirmed or suspected COVID-19 in any treatment setting.\n\nTwo reviewers independently extracted data on relevant clinical outcomes, trial characteristics, and patient characteristics and used the Cochrane Risk of Bias Assessment Tool. The primary analysis included peer-reviewed publications of RCTs only, whereas the secondary analysis included all publicly available RCT data (peer-reviewed publications, preprints, and press releases). Inverse variance-weighted meta-analyses were conducted to summarize the treatment effects. The certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation.\n\nAll-cause mortality, length of hospital stay, clinical improvement, clinical deterioration, mechanical ventilation use, and serious adverse events.\n\nA total of 1060 patients from 4 peer-reviewed RCTs and 10 722 patients from 6 other publicly available RCTs were included. The summary risk ratio (RR) for all-cause mortality with convalescent plasma in the 4 peer-reviewed RCTs was 0.93 (95% CI, 0.63 to 1.38), the absolute risk difference was -1.21% (95% CI, -5.29% to 2.88%), and there was low certainty of the evidence due to imprecision. Across all 10 RCTs, the summary RR was 1.02 (95% CI, 0.92 to 1.12) and there was moderate certainty of the evidence due to inclusion of unpublished data. Among the peer-reviewed RCTs, the summary hazard ratio was 1.17 (95% CI, 0.07 to 20.34) for length of hospital stay, the summary RR was 0.76 (95% CI, 0.20 to 2.87) for mechanical ventilation use (the absolute risk difference for mechanical ventilation use was -2.56% [95% CI, -13.16% to 8.05%]), and there was low certainty of the evidence due to imprecision for both outcomes. Limited data on clinical improvement, clinical deterioration, and serious adverse events showed no significant differences.\n\nTreatment with convalescent plasma compared with placebo or standard of care was not significantly associated with a decrease in all-cause mortality or with any benefit for other clinical outcomes. The certainty of the evidence was low to moderate for all-cause mortality and low for other outcomes.", "doi": "10.1001/jama.2021.2747", "pmid": "33635310", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "2777060"}], "notes": [], "created": "2021-03-01T10:31:35.067Z", "modified": "2021-03-01T10:31:35.077Z"}, {"entity": "publication", "iuid": "385673f5df3646bd8e3b61eeec8fda40", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/385673f5df3646bd8e3b61eeec8fda40.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/385673f5df3646bd8e3b61eeec8fda40"}}, "title": "Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19.", "authors": [{"family": "Gupta", "given": "Aakriti", "initials": "A"}, {"family": "Madhavan", "given": "Mahesh V", "initials": "MV"}, {"family": "Poterucha", "given": "Timothy J", "initials": "TJ"}, {"family": "DeFilippis", "given": "Ersilia M", "initials": "EM"}, {"family": "Hennessey", "given": "Jessica A", "initials": "JA"}, {"family": "Redfors", "given": "Bjorn", "initials": "B"}, {"family": "Eckhardt", "given": "Christina", "initials": "C"}, {"family": "Bikdeli", "given": "Behnood", "initials": "B"}, {"family": "Platt", "given": "Jonathan", "initials": "J"}, {"family": "Nalbandian", "given": "Ani", "initials": "A"}, {"family": "Elias", "given": "Pierre", "initials": "P"}, {"family": "Cummings", "given": "Matthew J", "initials": "MJ"}, {"family": "Nouri", "given": "Shayan N", "initials": "SN"}, {"family": "Lawlor", "given": "Matthew", "initials": "M"}, {"family": "Ranard", "given": "Lauren S", "initials": "LS"}, {"family": "Li", "given": "Jianhua", "initials": "J"}, {"family": "Boyle", "given": "Claudia", "initials": "C"}, {"family": "Givens", "given": "Raymond", "initials": "R"}, {"family": "Brodie", "given": "Daniel", "initials": "D"}, {"family": "Krumholz", "given": "Harlan M", "initials": "HM"}, {"family": "Stone", "given": "Gregg W", "initials": "GW"}, {"family": "Sethi", "given": "Sanjum S", "initials": "SS"}, {"family": "Burkhoff", "given": "Daniel", "initials": "D"}, {"family": "Uriel", "given": "Nir", "initials": "N"}, {"family": "Schwartz", "given": "Allan", "initials": "A"}, {"family": "Leon", "given": "Martin B", "initials": "MB"}, {"family": "Kirtane", "given": "Ajay J", "initials": "AJ"}, {"family": "Wan", "given": "Elaine Y", "initials": "EY"}, {"family": "Parikh", "given": "Sahil A", "initials": "SA"}], "type": "journal article", "published": "2021-02-26", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "1325", "issn-l": "2041-1723"}, "abstract": "The coronavirus disease 2019 (COVID-19) can result in a hyperinflammatory state, leading to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic complications, among other sequelae. Statins, which are known to have anti-inflammatory and antithrombotic properties, have been studied in the setting of other viral infections, but their benefit has not been assessed in COVID-19. This is a retrospective analysis of patients admitted with COVID-19 from February 1 st through May 12th, 2020 with study period ending on June 11th, 2020. Antecedent statin use was assessed using medication information available in the electronic medical record. We constructed a multivariable logistic regression model to predict the propensity of receiving statins, adjusting for baseline sociodemographic and clinical characteristics, and outpatient medications. The primary endpoint includes in-hospital mortality within 30 days. A total of 2626 patients were admitted during the study period, of whom 951 (36.2%) were antecedent statin users. Among 1296 patients (648 statin users, 648 non-statin users) identified with 1:1 propensity-score matching, statin use is significantly associated with lower odds of the primary endpoint in the propensity-matched cohort (OR 0.47, 95% CI 0.36-0.62, p < 0.001). We conclude that antecedent statin use in patients hospitalized with COVID-19 is associated with lower inpatient mortality.", "doi": "10.1038/s41467-021-21553-1", "pmid": "33637713", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-21553-1"}], "notes": [], "created": "2021-03-01T10:27:41.788Z", "modified": "2021-03-01T10:27:41.799Z"}, {"entity": "publication", "iuid": "83652c6eab6545dc856b7f96cab7fcbb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/83652c6eab6545dc856b7f96cab7fcbb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/83652c6eab6545dc856b7f96cab7fcbb"}}, "title": "A COVID-19 pandemic-specific, structured care process for Peritoneal Dialysis patients facilitated by Telemedicine: therapy continuity, prevention and complications management.", "authors": [{"family": "Polanco", "given": "Elianny", "initials": "E"}, {"family": "Aquey", "given": "Mercedes", "initials": "M"}, {"family": "Collado", "given": "Jhanna", "initials": "J"}, {"family": "Campos", "given": "Erwin", "initials": "E"}, {"family": "Guzman", "given": "Janny", "initials": "J"}, {"family": "Cuevas-Budhart", "given": "Miguel Angel", "initials": "MA"}, {"family": "Divino-Filho", "given": "Jos\u00e9 Carolino", "initials": "JC"}, {"family": "Ramos-Sanchez", "given": "Alfonso", "initials": "A"}], "type": "journal article", "published": "2021-02-26", "journal": {"title": "Ther Apher Dial", "issn": "1744-9987", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Coronavirus 2019 disease (COVID-19) has been declared a pandemia. Peritoneal dialysis (PD), being a home therapy, allows for physical distancing measures and movement restrictions. In order to prevent COVID-19 contagious among the Dominican Republic National Health System PD program patients, a follow up virtual protocol for this group was developed. The aim of this study is to outline the protocol established by the PD program's healthcare team using Telemedicine in order to avoid COVID-19 contagious and to report initial results and outcomes of this initiative.\r\n\r\nThis is an observational prospective longitudinal study with 946 patients being treated in seven centers distributed throughout the country between April 1 st and June 30th. The protocol was implemented focusing on the patient follow-up; risk mitigation data were registered and collected from electronic records.\r\n\r\nDuring the follow-up period, 95 catheters were implanted, 64 patients-initiated PD and the remaining were in training. A total of 9 532 consultations were given by the different team specialists, being 8 720 (91%) virtual and 812 (9%) face -to -face consultations. The transfer rate to HD was 0.29% whereas the peritonitis rate was 0.11 episode per patient/year. Eighteen adults tested positive for COVID-19.\r\n\r\nThe implementation of the protocol and Telemedicine utilization have ensured follow-up and monitoring, preserved therapy, controlled complications and PD lives protected. This article is protected by copyright. All rights reserved.", "doi": "10.1111/1744-9987.13635", "pmid": "33634948", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-03-01T10:32:43.595Z", "modified": "2021-06-18T14:28:10.323Z"}, {"entity": "publication", "iuid": "51fccdcf6a9d42be97470f6cd75694fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/51fccdcf6a9d42be97470f6cd75694fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/51fccdcf6a9d42be97470f6cd75694fc"}}, "title": "The fear of the COVID-19 Scale: validation in the Portuguese general population.", "authors": [{"family": "Soares", "given": "Francisca Ribeiro", "initials": "FR"}, {"family": "Afonso", "given": "Rosa Marina", "initials": "RM"}, {"family": "Martins", "given": "Ana Paula", "initials": "AP"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Rosa", "given": "Celina Pires", "initials": "CP"}], "type": "journal article", "published": "2021-02-25", "journal": {"title": "Death Stud", "issn": "1091-7683", "volume": null, "issue": null, "pages": "1-7", "issn-l": null}, "abstract": "The coronavirus disease (COVID-19) pandemic is having a profound effect on mental health and it is therefore fundamental to evaluate individual psychological responses to COVID-19. The 7-item Fear of COVID-19 Scale (FCV-19S) assesses different aspects of the fear of coronavirus and has been applied worldwide. This study aimed to translate and validate the FCV-19S in the Portuguese population. The scale was administered to a convenience sample of 1203 Portuguese adults. Exploratory factor analysis was carried out on the initial model proposed by the authors of the FCV-19S. Further analysis revealed that the Portuguese version has good psychometric properties.", "doi": "10.1080/07481187.2021.1889722", "pmid": "33630728", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-03-01T10:22:11.159Z", "modified": "2021-03-01T10:22:11.182Z"}, {"entity": "publication", "iuid": "0de3e14051a2404e9d8a3d49b564064c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0de3e14051a2404e9d8a3d49b564064c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0de3e14051a2404e9d8a3d49b564064c"}}, "title": "Long-term outcome after intensive care for COVID-19: differences between men and women-a nationwide cohort study.", "authors": [{"family": "Zettersten", "given": "Erik", "initials": "E"}, {"family": "Engerstr\u00f6m", "given": "Lars", "initials": "L"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "J\u00e4derling", "given": "Gabriella", "initials": "G"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}, {"family": "Block", "given": "Linda", "initials": "L"}, {"family": "Larsson", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2021-02-25", "journal": {"title": "Crit Care", "issn": "1466-609X", "volume": "25", "issue": "1", "pages": "86", "issn-l": "1364-8535"}, "abstract": "Questions remain about long-term outcome for COVID-19 patients in general, and differences between men and women in particular given the fact that men seem to suffer a more dramatic course of the disease. We therefore analysed outcome beyond 90 days in ICU patients with COVID-19, with special focus on differences between men and women.\n\nWe identified all patient \u2265 18 years with COVID-19 admitted between March 6 and June 30, 2020, in the Swedish Intensive Care Registry. Patients were followed until death or study end-point October 22, 2020. Association with patient sex and mortality, in addition to clinical variables, was estimated using Cox regression. We also performed a logistic regression model estimating factors associated with 90-day mortality.\n\nIn total, 2354 patients with COVID-19 were included. Four patients were still in the ICU at study end-point. Median follow-up time was 183 days. Mortality at 90-days was 26.9%, 23.4% in women and 28.2% in men. After 90 days until end of follow-up, only 11 deaths occurred. On multivariable Cox regression analysis, male sex (HR 1.28, 95% CI 1.06-1.54) remained significantly associated with mortality even after adjustments. Additionally, age, COPD/asthma, immune deficiency, malignancy, SAPS3 and admission month were associated with mortality. The logistic regression model of 90-day mortality showed almost identical results.\n\nIn this nationwide study of ICU patients with COVID-19, men were at higher risk of poor long-term outcome compared to their female counterparts. The underlying mechanisms for these differences are not fully understood and warrant further studies.", "doi": "10.1186/s13054-021-03511-x", "pmid": "33632273", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-021-03511-x"}, {"db": "pmc", "key": "PMC7906087"}], "notes": [], "created": "2021-03-09T06:31:12.788Z", "modified": "2021-03-09T06:33:30.216Z"}, {"entity": "publication", "iuid": "2850b672e81a4a34a39690a4cf8de736", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2850b672e81a4a34a39690a4cf8de736.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2850b672e81a4a34a39690a4cf8de736"}}, "title": "Genetic predisposition to psychiatric disorders and risk of COVID-19", "authors": [{"family": "Chen", "given": "Wenwen", "initials": "W"}, {"family": "Zeng", "given": "Yu", "initials": "Y"}, {"family": "Suo", "given": "Chen", "initials": "C"}, {"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Chen", "given": "Yilong", "initials": "Y"}, {"family": "Hou", "given": "Can", "initials": "C"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "Sun", "given": "Yajing", "initials": "Y"}, {"family": "Qu", "given": "Yuanyuan", "initials": "Y"}, {"family": "Lu", "given": "Donghao", "initials": "D"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "posted-content", "published": "2021-02-25", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.23.21251866", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-03-25T14:07:18.181Z", "modified": "2021-05-17T19:30:55.631Z"}, {"entity": "publication", "iuid": "0fab6b563c944cb3bc40603c2e02acad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0fab6b563c944cb3bc40603c2e02acad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0fab6b563c944cb3bc40603c2e02acad"}}, "title": "Beyond Chronological Age: Frailty and Multimorbidity Predict In-Hospital Mortality in Patients With Coronavirus Disease 2019.", "authors": [{"family": "Marengoni", "given": "Alessandra", "initials": "A"}, {"family": "Zucchelli", "given": "Alberto", "initials": "A", "orcid": "0000-0001-5992-8506", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5ad05bd796f49c983931341109b1578.json"}}, {"family": "Vetrano", "given": "Davide Liborio", "initials": "DL", "orcid": "0000-0002-3099-4830", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0124721bb214413a34c965b6accc64b.json"}}, {"family": "Armellini", "given": "Andrea", "initials": "A"}, {"family": "Botteri", "given": "Emanuele", "initials": "E"}, {"family": "Nicosia", "given": "Franco", "initials": "F"}, {"family": "Romanelli", "given": "Giuseppe", "initials": "G"}, {"family": "Beindorf", "given": "Eva Andrea", "initials": "EA"}, {"family": "Giansiracusa", "given": "Paola", "initials": "P"}, {"family": "Garrafa", "given": "Emirena", "initials": "E"}, {"family": "Ferrucci", "given": "Luigi", "initials": "L", "orcid": "0000-0002-6273-1613", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2edec69f580a4daea9ee99fa666c8f53.json"}}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Bernabei", "given": "Roberto", "initials": "R"}, {"family": "Onder", "given": "Graziano", "initials": "G"}], "type": "journal article", "published": "2021-02-25", "journal": {"title": "J Gerontol A Biol Sci Med Sci", "issn": "1758-535X", "issn-l": "1079-5006", "volume": "76", "issue": "3", "pages": "e38-e45"}, "abstract": "We evaluated whether frailty and multimorbidity predict in-hospital mortality in patients with COVID-19 beyond chronological age.\n\nA total of 165 patients admitted from March 8th to April 17th, 2020, with COVID-19 in an acute geriatric ward in Italy were included. Predisease frailty was assessed with the Clinical Frailty Scale (CFS). Multimorbidity was defined as the co-occurrence of \u22652 diseases in the same patient. The hazard ratio (HR) of in-hospital mortality as a function of CFS score and number of chronic diseases in the whole population and in those aged 70+ years were calculated.\n\nAmong the 165 patients, 112 were discharged, 11 were transferred to intensive care units, and 42 died. Patients who died were older (81.0 vs 65.2 years, p < .001), more frequently multimorbid (97.6 vs 52.8%; p < .001), and more likely frail (37.5 vs 4.1%; p < .001). Less than 2.0% of patients without multimorbidity and frailty, 28% of those with multimorbidity only, and 75% of those with both multimorbidity and frailty died. Each unitary increment in the CFS was associated with a higher risk of in-hospital death in the whole sample (HR = 1.3; 95% CI = 1.05-1.62) and in patients aged 70+ years (HR = 1.29; 95% CI = 1.04-1.62), whereas the number of chronic diseases was not significantly associated with higher risk of death. The CFS addition to age and sex increased mortality prediction by 9.4% in those aged 70+ years.\n\nFrailty identifies patients with COVID-19 at risk of in-hospital death independently of age. Multimorbidity contributes to prognosis because of the very low probability of death in its absence.", "doi": "10.1093/gerona/glaa291", "pmid": "33216846", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7717138"}, {"db": "pii", "key": "5996087"}], "notes": [], "created": "2020-11-26T14:33:41.983Z", "modified": "2023-06-19T15:29:21.072Z"}, {"entity": "publication", "iuid": "9c0721ae5def464c81523f9e3565392e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9c0721ae5def464c81523f9e3565392e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9c0721ae5def464c81523f9e3565392e"}}, "title": "A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.", "authors": [{"family": "Zhou", "given": "Sirui", "initials": "S"}, {"family": "Butler-Laporte", "given": "Guillaume", "initials": "G"}, {"family": "Nakanishi", "given": "Tomoko", "initials": "T"}, {"family": "Morrison", "given": "David R", "initials": "DR"}, {"family": "Afilalo", "given": "Jonathan", "initials": "J"}, {"family": "Afilalo", "given": "Marc", "initials": "M"}, {"family": "Laurent", "given": "Laetitia", "initials": "L"}, {"family": "Pietzner", "given": "Maik", "initials": "M"}, {"family": "Kerrison", "given": "Nicola", "initials": "N"}, {"family": "Zhao", "given": "Kaiqiong", "initials": "K"}, {"family": "Brunet-Ratnasingham", "given": "Elsa", "initials": "E"}, {"family": "Henry", "given": "Danielle", "initials": "D"}, {"family": "Kimchi", "given": "Nofar", "initials": "N"}, {"family": "Afrasiabi", "given": "Zaman", "initials": "Z"}, {"family": "Rezk", "given": "Nardin", "initials": "N"}, {"family": "Bouab", "given": "Meriem", "initials": "M"}, {"family": "Petitjean", "given": "Louis", "initials": "L"}, {"family": "Guzman", "given": "Charlotte", "initials": "C"}, {"family": "Xue", "given": "Xiaoqing", "initials": "X"}, {"family": "Tselios", "given": "Chris", "initials": "C"}, {"family": "Vulesevic", "given": "Branka", "initials": "B"}, {"family": "Adeleye", "given": "Olumide", "initials": "O"}, {"family": "Abdullah", "given": "Tala", "initials": "T"}, {"family": "Almamlouk", "given": "Noor", "initials": "N"}, {"family": "Chen", "given": "Yiheng", "initials": "Y"}, {"family": "Chass\u00e9", "given": "Micha\u00ebl", "initials": "M"}, {"family": "Durand", "given": "Madeleine", "initials": "M"}, {"family": "Paterson", "given": "Clare", "initials": "C"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Greenwood", "given": "Celia M T", "initials": "CMT"}, {"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "Langenberg", "given": "Claudia", "initials": "C"}, {"family": "Thysell", "given": "Elin", "initials": "E"}, {"family": "Pollak", "given": "Michael", "initials": "M"}, {"family": "Mooser", "given": "Vincent", "initials": "V"}, {"family": "Forgetta", "given": "Vincenzo", "initials": "V"}, {"family": "Kaufmann", "given": "Daniel E", "initials": "DE"}, {"family": "Richards", "given": "J Brent", "initials": "JB"}], "type": "journal article", "published": "2021-02-25", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956", "volume": "27", "issue": "4", "pages": "659-667"}, "abstract": "To identify circulating proteins influencing Coronavirus Disease 2019 (COVID-19) susceptibility and severity, we undertook a two-sample Mendelian randomization (MR) study, rapidly scanning hundreds of circulating proteins while reducing bias due to reverse causation and confounding. In up to 14,134 cases and 1.2 million controls, we found that an s.d. increase in OAS1 levels was associated with reduced COVID-19 death or ventilation (odds ratio (OR) = 0.54, P = 7 \u00d7 10 -8), hospitalization (OR = 0.61, P = 8 \u00d7 10-8) and susceptibility (OR = 0.78, P = 8 \u00d7 10-6). Measuring OAS1 levels in 504 individuals, we found that higher plasma OAS1 levels in a non-infectious state were associated with reduced COVID-19 susceptibility and severity. Further analyses suggested that a Neanderthal isoform of OAS1 in individuals of European ancestry affords this protection. Thus, evidence from MR and a case-control study support a protective role for OAS1 in COVID-19 adverse outcomes. Available pharmacological agents that increase OAS1 levels could be prioritized for drug development.", "doi": "10.1038/s41591-021-01281-1", "pmid": "33633408", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-021-01281-1"}], "notes": [], "created": "2021-03-01T10:33:22.847Z", "modified": "2021-05-27T16:07:53.701Z"}, {"entity": "publication", "iuid": "27dbd4e1c95d41ada0ae228dda5eda93", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27dbd4e1c95d41ada0ae228dda5eda93.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27dbd4e1c95d41ada0ae228dda5eda93"}}, "title": "Ophthalmic Screening in Patients with Coronavirus Disease 2019: A Prospective Cohort Study.", "authors": [{"family": "Papazoglou", "given": "Anthia", "initials": "A"}, {"family": "Conen", "given": "Anna", "initials": "A"}, {"family": "Haubitz", "given": "Sebastian", "initials": "S"}, {"family": "Tschopp", "given": "Markus", "initials": "M"}, {"family": "Guignard", "given": "Viviane J", "initials": "VJ"}, {"family": "Menke", "given": "Marcel N", "initials": "MN"}, {"family": "Enz", "given": "Tim J", "initials": "TJ"}], "type": "journal article", "published": "2021-02-24", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "10", "issue": "5", "pages": null}, "abstract": "Postmortem pathological examinations, animal studies, and anecdotal reports suggest that coronavirus disease 2019 (COVID-19) could potentially affect intraocular tissue. However, published evidence is scarce and conflicting. In our study, we screened 100 eyes of 50 patients hospitalized for COVID-19. Relevant medical and ophthalmological history was assessed as well as symptoms, laboratory results, specific treatments, clinical course, and outcome. Ophthalmic exams including assessment of best corrected visual acuity (BCVA), intraocular pressure (IOP), color perception, ocular motility, ophthalmoscopy as well as optical coherence tomography (OCT) of the macula and the optic disc was performed at hospital admission and 29 to 192 days later. Of the 50 patients included, 14 (28%) were female. Median age was 64.5 (range 29-90) years. COVID-19 severity was mild in 15 (30%), severe in 30 (60%), and critical in five cases (10%). At baseline, median BCVA was 0.1 (0-1.8) Logarithm of the Minimum Angle of Resolution (LogMAR) and median IOP was 16 (8-22) mmHg. At follow-up, no relevant changes in BCVA and IOP were documented. No signs of active intraocular inflammation or optic nerve affection were found and OCT findings were widely stable during the observation period. Our findings suggest that COVID-19 does not regularly affect intraocular tissue.", "doi": "10.3390/jcm10050896", "pmid": "33668256", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "jcm10050896"}, {"db": "URL", "key": "https://www.mdpi.com/2077-0383/10/5/896/s1", "description": "Patient characteristics, medical treatment regiments, symptoms, laboratory findings, ophthalmic findings, systemic symtoms for each patient"}], "notes": [], "created": "2021-03-08T05:28:12.245Z", "modified": "2021-06-18T12:52:19.368Z"}, {"entity": "publication", "iuid": "f3681b42d7da4392816918aab5db8ce7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f3681b42d7da4392816918aab5db8ce7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f3681b42d7da4392816918aab5db8ce7"}}, "title": "Multisystem inflammatory syndrome in children and adults (MIS-C/A): Case definition & guidelines for data collection, analysis, and presentation of immunization safety data.", "authors": [{"family": "Vogel", "given": "Tiphanie P", "initials": "TP"}, {"family": "Top", "given": "Karina A", "initials": "KA"}, {"family": "Karatzios", "given": "Christos", "initials": "C"}, {"family": "Hilmers", "given": "David C", "initials": "DC"}, {"family": "Tapia", "given": "Lorena I", "initials": "LI"}, {"family": "Moceri", "given": "Pamela", "initials": "P"}, {"family": "Giovannini-Chami", "given": "Lisa", "initials": "L"}, {"family": "Wood", "given": "Nicholas", "initials": "N"}, {"family": "Chandler", "given": "Rebecca E", "initials": "RE"}, {"family": "Klein", "given": "Nicola P", "initials": "NP"}, {"family": "Schlaudecker", "given": "Elizabeth P", "initials": "EP"}, {"family": "Poli", "given": "M Cecilia", "initials": "MC"}, {"family": "Muscal", "given": "Eyal", "initials": "E"}, {"family": "Munoz", "given": "Flor M", "initials": "FM"}], "type": "journal article", "published": "2021-02-24", "journal": {"title": "Vaccine", "issn": "1873-2518", "volume": null, "issue": null, "issn-l": null}, "abstract": "This is a Brighton Collaboration Case Definition of the term \"Multisystem Inflammatory Syndrome in Children and Adults (MIS-C/A)\" to be utilized in the evaluation of adverse events following immunization. The case definition was developed by topic experts convened by the Coalition for Epidemic Preparedness Innovations (CEPI) in the context of active development of vaccines for SARS-CoV-2. The format of the Brighton Collaboration was followed, including an exhaustive review of the literature, to develop a consensus definition and defined levels of certainty. The document underwent peer review by the Brighton Collaboration Network and by selected expert external reviewers prior to submission. The comments of the reviewers were taken into consideration and edits incorporated into this final manuscript.", "doi": "10.1016/j.vaccine.2021.01.054", "pmid": "33640145", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(21)00093-1"}], "notes": [], "created": "2021-03-01T10:25:43.038Z", "modified": "2021-03-01T10:25:43.048Z"}, {"entity": "publication", "iuid": "66da60a87f714d26af9d07d6218d0f85", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66da60a87f714d26af9d07d6218d0f85.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66da60a87f714d26af9d07d6218d0f85"}}, "title": "Impact of winter holiday and government responses on mortality in Europe during the first wave of the COVID-19 pandemic.", "authors": [{"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}, {"family": "Mattisson", "given": "Kristoffer", "initials": "K"}, {"family": "Ahlbom", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2021-02-24", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": null, "issue": null, "pages": null}, "abstract": "This aggregated population study investigated the impact of the seemingly quasi-randomly assigned school winter holiday in week 6-10 (February to early March) on excess mortality in 219 European regions (11 countries) during the COVID-19 pandemic in the spring 2020. A secondary aim was to evaluate the impact of government responses to the early inflow of infected cases.\r\n\r\nData on government responses week 8-14 were obtained from the Oxford COVID-19 Government Response Tracker. Regional data on total all-cause mortality during week 14-23 in 2020 were retrieved from Eurostat and national statistical agencies and compared with the average mortality during same period 2015-2019. Variance-weighted least square regression was used with mortality difference as dependent variable with adjustment for country, population density and age distribution.\r\n\r\nBeing a region with winter holiday exclusively in week 9 was in the adjusted analysis associated with 16 weekly excess deaths (95% confidence interval 13 to 20) per million inhabitants during week 14-23, which corresponds to 38% of the excess mortality in these regions. A more stringent response implemented in week 11, corresponding to 10 additional units on the 0-100 ordinal scale, was associated with 20 fewer weekly deaths (95% confidence interval 18 to 22) per million inhabitants.\r\n\r\nWinter holiday in week 9 was an amplifying event that contributed importantly to the excess mortality observed in the study regions during the spring 2020. Timely government responses to the resulting early inflow of cases reduced the excess in mortality.", "doi": "10.1093/eurpub/ckab017", "pmid": "33624821", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6149087"}], "notes": [], "created": "2021-02-25T10:12:25.738Z", "modified": "2021-06-18T14:24:11.844Z"}, {"entity": "publication", "iuid": "24a65e888eac4b9e8306546e341d401c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/24a65e888eac4b9e8306546e341d401c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/24a65e888eac4b9e8306546e341d401c"}}, "title": "COVID-19 drug practices risk antimicrobial resistance evolution.", "authors": [{"family": "Afshinnekoo", "given": "Ebrahim", "initials": "E"}, {"family": "Bhattacharya", "given": "Chandrima", "initials": "C"}, {"family": "Burguete-Garc\u00eda", "given": "Ana", "initials": "A"}, {"family": "Castro-Nallar", "given": "Eduardo", "initials": "E"}, {"family": "Deng", "given": "Youping", "initials": "Y"}, {"family": "Desnues", "given": "Christelle", "initials": "C"}, {"family": "Dias-Neto", "given": "Emmanuel", "initials": "E"}, {"family": "Elhaik", "given": "Eran", "initials": "E"}, {"family": "Iraola", "given": "Gregorio", "initials": "G"}, {"family": "Jang", "given": "Soojin", "initials": "S"}, {"family": "\u0141abaj", "given": "Pawe\u0142 P", "initials": "PP"}, {"family": "Mason", "given": "Christopher E", "initials": "CE"}, {"family": "Nagarajan", "given": "Niranjan", "initials": "N"}, {"family": "Poulsen", "given": "Michael", "initials": "M"}, {"family": "Prithiviraj", "given": "Bharath", "initials": "B"}, {"family": "Siam", "given": "Rania", "initials": "R"}, {"family": "Shi", "given": "Tieliu", "initials": "T"}, {"family": "Suzuki", "given": "Haruo", "initials": "H"}, {"family": "Werner", "given": "Johannes", "initials": "J"}, {"family": "Zambrano", "given": "Maria Mercedes", "initials": "MM"}, {"family": "Bhattacharyya", "given": "Malay", "initials": "M"}, {"family": "MetaSUB Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2021-02-24", "journal": {"title": "The Lancet Microbe", "issn": "2666-5247", "volume": null, "issue": null, "issn-l": "2666-5247"}, "abstract": null, "doi": "10.1016/S2666-5247(21)00039-2", "pmid": "33655229", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2666-5247(21)00039-2"}, {"db": "pmc", "key": "PMC7906697"}], "notes": [], "created": "2021-03-04T15:02:32.660Z", "modified": "2021-03-04T15:03:01.727Z"}, {"entity": "publication", "iuid": "70eb4ec5d8b546539a46419b7a79a095", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70eb4ec5d8b546539a46419b7a79a095.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70eb4ec5d8b546539a46419b7a79a095"}}, "title": "Mental health among elite athletes in Norway during a selected period of the COVID-19 pandemic.", "authors": [{"family": "Pensgaard", "given": "Anne Marte", "initials": "AM", "orcid": "0000-0003-4690-9888", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec779958709e4ca18ff8fdf000d55075.json"}}, {"family": "Oevreboe", "given": "Tom Henning", "initials": "TH", "orcid": "0000-0003-4965-1018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee49f62a86ee4e97a5cc820570933f27.json"}}, {"family": "Ivarsson", "given": "Andreas", "initials": "A", "orcid": "0000-0002-8987-5975", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e77e48568e184548a5da063cb6b339be.json"}}], "type": "journal article", "published": "2021-02-23", "journal": {"title": "BMJ Open Sport Exerc Med", "issn": "2055-7647", "volume": "7", "issue": "1", "pages": "e001025", "issn-l": null}, "abstract": "To investigate the prevalence of mental health problems and satisfaction with life among different groups of elite athletes during a selected period of the COVID-19 pandemic and examine how COVID-19 related consequences were associated with these variables.\n\nCross-sectional data collection during a selected period of the COVID-19 pandemic in Norway.\n\n378 elite athletes, mean age 26.86 (range 18-59), 159 females and 219 males, divided into Olympic-level and Paralympic-level athletes (n=194) and elite and semielite athletes (n=184).\n\nHopkins Symptoms Check List - 10; symptoms of anxiety and depression; Bergen Insomnia Scale; Eating Disorder Examination Questionnaire Short; Canadian Problem Gambling Index and Satisfaction with Life Scale. In addition, we included specific COVID-19 questions (eg, financial concern, keeping daily routines, perceived coping and motivation).\n\nSymptoms of insomnia (38.3%) and depression (22.3%) were most prevalent within the sample. Symptoms of eating disorders more prevalent among female athletes (8.8% vs 1.4%) while symptoms of gambling problems were higher among male athletes (8.6% vs 1.3%). Olympic and Paralympic athletes reported lower levels of anxiety and depression symptoms than elite and semielite athletes. Financial concerns were associated with an increased risk of mental health problems, while daily routines and perception of coping were associated with less mental health problems and higher satisfaction with life.\n\nSymptoms of insomnia and depression were the two most common mental health problems reported during this selected phase of the COVID-19 pandemic. Elite and semielite athletes reported financial concerns as a risk factor for mental health problems at a larger degree than Olympic and Paralympic athletes.", "doi": "10.1136/bmjsem-2020-001025", "pmid": "34192011", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjsem-2020-001025"}, {"db": "pmc", "key": "PMC7907612"}], "notes": [], "created": "2021-07-05T14:26:16.214Z", "modified": "2021-07-05T15:08:54.718Z"}, {"entity": "publication", "iuid": "90f48cf5d5dd4a08b86cc84031aec1c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90f48cf5d5dd4a08b86cc84031aec1c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90f48cf5d5dd4a08b86cc84031aec1c9"}}, "title": "Impact of the COVID-19 pandemic on morbidity and mortality in patients with inflammatory joint diseases and in the general population: a nationwide Swedish cohort study.", "authors": [{"family": "Bower", "given": "Hannah", "initials": "H"}, {"family": "Frisell", "given": "Thomas", "initials": "T"}, {"family": "Di Giuseppe", "given": "Daniela", "initials": "D"}, {"family": "Delcoigne", "given": "B\u00e9n\u00e9dicte", "initials": "B"}, {"family": "Ahlenius", "given": "Gerd-Marie", "initials": "G"}, {"family": "Baecklund", "given": "Eva", "initials": "E"}, {"family": "Chatzidionysiou", "given": "Katerina", "initials": "K"}, {"family": "Feltelius", "given": "Nils", "initials": "N"}, {"family": "Forsblad-d'Elia", "given": "Helena", "initials": "H"}, {"family": "Kastbom", "given": "Alf", "initials": "A"}, {"family": "Klareskog", "given": "Lars", "initials": "L"}, {"family": "Lindqvist", "given": "Elisabet", "initials": "E"}, {"family": "Lindstr\u00f6m", "given": "Ulf", "initials": "U"}, {"family": "Turesson", "given": "Carl", "initials": "C"}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C"}, {"family": "Askling", "given": "Johan", "initials": "J"}, {"family": "ARTIS Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-02-23", "journal": {"title": "Ann Rheum Dis", "issn": "1468-2060", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To estimate absolute and relative risks for all-cause mortality and for severe COVID-19 in inflammatory joint diseases (IJDs) and with antirheumatic therapies.\r\n\r\nThrough Swedish nationwide multiregister linkages, we selected all adult patients with rheumatoid arthritis (RA, n=53 455 in March 2020), other IJDs (here: spondyloarthropathies, psoriatic arthritis and juvenile idiopathic arthritis, n=57 112), their antirheumatic drug use, and individually matched population referents. We compared annual all-cause mortality March-September 2015 through 2020 within and across cohorts, and assessed absolute and relative risks for hospitalisation, admission to intensive care and death due to COVID-19 March-September 2020, using Cox regression.\r\n\r\nDuring March-September 2020, the absolute all-cause mortality in RA and in other IJDs was higher than 2015-2019, but relative risks versus the general population (around 2 and 1.5) remained similar during 2020 compared with 2015-2019. Among patients with IJD, the risks of hospitalisation (0.5% vs 0.3% in their population referents), admission to intensive care (0.04% vs 0.03%) and death (0.10% vs 0.07%) due to COVID-19 were low. Antirheumatic drugs were not associated with increased risk of serious COVID-19 outcomes, although for certain drugs, precision was limited.\r\n\r\nRisks of severe COVID-19-related outcomes were increased among patients with IJDs, but risk increases were also seen for non-COVID-19 morbidity. Overall absolute and excess risks are low and the level of risk increases are largely proportionate to those in the general population, and explained by comorbidities. With possible exceptions, antirheumatic drugs do not have a major impact on these risks.", "doi": "10.1136/annrheumdis-2021-219845", "pmid": "33622688", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "annrheumdis-2021-219845"}], "notes": [], "created": "2021-02-25T12:30:45.045Z", "modified": "2021-06-18T14:23:09.973Z"}, {"entity": "publication", "iuid": "1587f1507ee34fd9ba0ae982cdb57e9a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1587f1507ee34fd9ba0ae982cdb57e9a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1587f1507ee34fd9ba0ae982cdb57e9a"}}, "title": "Critical COVID-19 represents an endothelial disease with high similarity to kidney disease on the molecular level", "authors": [{"family": "Siwy", "given": "Justyna", "initials": "J"}, {"family": "Wendt", "given": "Ralph", "initials": "R"}, {"family": "Albalat", "given": "Amaya", "initials": "A"}, {"family": "He", "given": "Tianlin", "initials": "T"}, {"family": "Mischak", "given": "Harald", "initials": "H"}, {"family": "Mullen", "given": "William", "initials": "W"}, {"family": "Latosinska", "given": "Agnieszka", "initials": "A"}, {"family": "Luebbert", "given": "Christoph", "initials": "C"}, {"family": "Kalbitz", "given": "Sven", "initials": "S"}, {"family": "Mebazaa", "given": "Alexandre", "initials": "A"}, {"family": "Peters", "given": "Bjoern", "initials": "B"}, {"family": "Stegmayr", "given": "Bernd", "initials": "B"}, {"family": "Spasovski", "given": "Goce", "initials": "G"}, {"family": "Wiech", "given": "Thorsten", "initials": "T"}, {"family": "Staessen", "given": "Jan", "initials": "J"}, {"family": "Wolf", "given": "Johannes", "initials": "J"}, {"family": "Beige", "given": "Joachim", "initials": "J"}], "type": "posted-content", "published": "2021-02-23", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.22.21252207", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-24T06:19:47.773Z", "modified": "2021-02-26T08:45:47.876Z"}, {"entity": "publication", "iuid": "3a3d1d8fbf594a02997f31c228efb07e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a3d1d8fbf594a02997f31c228efb07e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a3d1d8fbf594a02997f31c228efb07e"}}, "title": "Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients.", "authors": [{"family": "Zhao", "given": "Yu", "initials": "Y"}, {"family": "Kilian", "given": "Christoph", "initials": "C"}, {"family": "Turner", "given": "Jan-Eric", "initials": "JE"}, {"family": "Bosurgi", "given": "Lidia", "initials": "L"}, {"family": "Roedl", "given": "Kevin", "initials": "K"}, {"family": "Bartsch", "given": "Patricia", "initials": "P"}, {"family": "Gnirck", "given": "Ann-Christin", "initials": "AC"}, {"family": "Cortesi", "given": "Filippo", "initials": "F"}, {"family": "Schulthei\u00df", "given": "Christoph", "initials": "C"}, {"family": "Hellmig", "given": "Malte", "initials": "M"}, {"family": "Enk", "given": "Leon U B", "initials": "LUB"}, {"family": "Hausmann", "given": "Fabian", "initials": "F"}, {"family": "Borchers", "given": "Alina", "initials": "A"}, {"family": "Wong", "given": "Milagros N", "initials": "MN"}, {"family": "Paust", "given": "Hans-Joachim", "initials": "HJ"}, {"family": "Siracusa", "given": "Francesco", "initials": "F"}, {"family": "Scheibel", "given": "Nicola", "initials": "N"}, {"family": "Herrmann", "given": "Marissa", "initials": "M"}, {"family": "Rosati", "given": "Elisa", "initials": "E"}, {"family": "Bacher", "given": "Petra", "initials": "P"}, {"family": "Kylies", "given": "Dominik", "initials": "D"}, {"family": "Jarczak", "given": "Dominik", "initials": "D"}, {"family": "L\u00fctgehetmann", "given": "Marc", "initials": "M"}, {"family": "Pfefferle", "given": "Susanne", "initials": "S"}, {"family": "Steurer", "given": "Stefan", "initials": "S"}, {"family": "Zur-Wiesch", "given": "Julian Schulze", "initials": "JS"}, {"family": "Puelles", "given": "Victor G", "initials": "VG"}, {"family": "Sperhake", "given": "Jan-Peter", "initials": "JP"}, {"family": "Addo", "given": "Marylyn M", "initials": "MM"}, {"family": "Lohse", "given": "Ansgar W", "initials": "AW"}, {"family": "Binder", "given": "Mascha", "initials": "M"}, {"family": "Huber", "given": "Samuel", "initials": "S"}, {"family": "Huber", "given": "Tobias B", "initials": "TB"}, {"family": "Kluge", "given": "Stefan", "initials": "S"}, {"family": "Bonn", "given": "Stefan", "initials": "S"}, {"family": "Panzer", "given": "Ulf", "initials": "U"}, {"family": "Gagliani", "given": "Nicola", "initials": "N"}, {"family": "Krebs", "given": "Christian F", "initials": "CF"}], "type": "journal article", "published": "2021-02-23", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "volume": "6", "issue": "56", "issn-l": "2470-9468"}, "abstract": "Hyperinflammation contributes to lung injury and subsequent acute respiratory distress syndrome (ARDS) with high mortality in patients with severe coronavirus disease 2019 (COVID-19). To understand the underlying mechanisms involved in lung pathology, we investigated the role of the lung-specific immune response. We profiled immune cells in bronchoalveolar lavage fluid and blood collected from COVID-19 patients with severe disease and bacterial pneumonia patients not associated with viral infection. By tracking T cell clones across tissues, we identified clonally expanded tissue-resident memory-like Th17 cells (Trm17 cells) in the lungs even after viral clearance. These Trm17 cells were characterized by a a potentially pathogenic cytokine expression profile of IL17A and CSF2 (GM-CSF). Interactome analysis suggests that Trm17 cells can interact with lung macrophages and cytotoxic CD8+ T cells, which have been associated with disease severity and lung damage. High IL-17A and GM-CSF protein levels in the serum of COVID-19 patients were associated with a more severe clinical course. Collectively, our study suggests that pulmonary Trm17 cells are one potential orchestrator of the hyperinflammation in severe COVID-19.", "doi": "10.1126/sciimmunol.abf6692", "pmid": "33622974", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6/56/eabf6692"}], "notes": [], "created": "2021-02-25T12:27:16.311Z", "modified": "2021-02-26T08:45:48.060Z"}, {"entity": "publication", "iuid": "1b7f181e2f4d46e098cde3f9ce275f58", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b7f181e2f4d46e098cde3f9ce275f58.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b7f181e2f4d46e098cde3f9ce275f58"}}, "title": "The Outcome of Critically Ill COVID-19 Patients Is Linked to Thromboinflammation Dominated by the Kallikrein/Kinin System.", "authors": [{"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Persson", "given": "Barbro", "initials": "B"}, {"family": "Eriksson", "given": "Oskar", "initials": "O"}, {"family": "Blom", "given": "Anna M", "initials": "AM"}, {"family": "Fromell", "given": "Karin", "initials": "K"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Huber-Lang", "given": "Markus", "initials": "M"}, {"family": "Ekdahl", "given": "Kristina N", "initials": "KN"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Nilsson", "given": "Bo", "initials": "B"}], "type": "journal article", "published": "2021-02-22", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "12", "issue": null, "pages": "627579"}, "abstract": "An important manifestation of severe COVID-19 is the ARDS-like lung injury that is associated with vascular endothelialitis, thrombosis, and angiogenesis. The intravascular innate immune system (IIIS), including the complement, contact, coagulation, and fibrinolysis systems, which is crucial for recognizing and eliminating microorganisms and debris in the body, is likely to be involved in the pathogenesis of COVID-19 ARDS. Biomarkers for IIIS activation were studied in the first 66 patients with COVID-19 admitted to the ICU in Uppsala University Hospital, both cross-sectionally on day 1 and in 19 patients longitudinally for up to a month, in a prospective study. IIIS analyses were compared with biochemical parameters and clinical outcome and survival. Blood cascade systems activation leading to an overreactive conjunct thromboinflammation was demonstrated, reflected in consumption of individual cascade system components, e.g., FXII, prekallikrein, and high molecular weight kininogen and in increased levels of activation products, e.g., C4d, C3a, C3d,g, sC5b-9, TAT, and D-dimer. Strong associations were found between the blood cascade systems and organ damage, illness severity scores, and survival. We show that critically ill COVID-19 patients display a conjunct activation of the IIIS that is linked to organ damage of the lung, heart, kidneys, and death. We present evidence that the complement and in particular the kallikrein/kinin system is strongly activated and that both systems are prognostic markers of the outcome of the patients suggesting their role in driving the inflammation. Already licensed kallikrein/kinin inhibitors are potential drugs for treatment of critically ill patients with COVID-19.", "doi": "10.3389/fimmu.2021.627579", "pmid": "33692801", "labels": {"Funder: VR": null, "Category: Health": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "pmc", "key": "PMC7937878"}], "notes": [], "created": "2021-03-12T06:30:27.350Z", "modified": "2022-02-14T15:59:07.466Z"}, {"entity": "publication", "iuid": "59c5edd4606e4ff6b9b1f5c02df9ffb5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/59c5edd4606e4ff6b9b1f5c02df9ffb5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/59c5edd4606e4ff6b9b1f5c02df9ffb5"}}, "title": "Indirect Immunofluorescence for Detecting Anti-Neuronal Autoimmunity in CSF after COVID-19 - Possibilities and Pitfalls.", "authors": [{"family": "Mulder", "given": "Jan", "initials": "J"}, {"family": "Lindqvist", "given": "Isa", "initials": "I"}, {"family": "Rasmusson", "given": "Annica J", "initials": "AJ"}, {"family": "Hus\u00e9n", "given": "Evelina", "initials": "E"}, {"family": "R\u00f6nnelid", "given": "Johan", "initials": "J"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "Cunningham", "given": "Janet L", "initials": "JL"}], "type": "letter", "published": "2021-02-22", "journal": {"title": "Brain Behav Immun", "issn": "1090-2139", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/j.bbi.2021.02.013", "pmid": "33631284", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S0889-1591(21)00078-7"}], "notes": [], "created": "2021-03-01T10:24:42.657Z", "modified": "2021-03-01T10:25:01.801Z"}, {"entity": "publication", "iuid": "463bf10b1aa84edb89f6a8d116341e93", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/463bf10b1aa84edb89f6a8d116341e93.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/463bf10b1aa84edb89f6a8d116341e93"}}, "title": "Frailty and comorbidity in predicting community COVID \u201019 mortality in the UK Biobank: the effect of sampling", "authors": [{"family": "Mak", "given": "Jonathan K L", "initials": "JKL"}, {"family": "Kuja\u2010Halkola", "given": "Ralf", "initials": "R"}, {"family": "Wang", "given": "Yunzhang", "initials": "Y"}, {"family": "H\u00e4gg", "given": "Sara", "initials": "S"}, {"family": "Jylh\u00e4v\u00e4", "given": "Juulia", "initials": "J"}], "type": "journal-article", "published": "2021-02-22", "journal": {"title": "J Am Geriatr Soc", "issn": "0002-8614", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1111/jgs.17089", "pmid": null, "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-24T06:15:15.735Z", "modified": "2021-06-18T14:21:14.474Z"}, {"entity": "publication", "iuid": "f7f307cb36194462b403a98c216e3d2f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7f307cb36194462b403a98c216e3d2f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7f307cb36194462b403a98c216e3d2f"}}, "title": "Digitalizing a Brief Intervention to Reduce Intrusive Memories of Psychological Trauma: Qualitative Interview Study", "authors": [{"family": "Gamble", "given": "Beau", "initials": "B"}, {"family": "Depa", "given": "Katherine", "initials": "K"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}, {"family": "Kanstrup", "given": "Marie", "initials": "M"}], "type": "journal-article", "published": "2021-02-22", "journal": {"title": "JMIR Ment Health", "issn": "2368-7959", "volume": "8", "issue": "2", "pages": "e23712", "issn-l": null}, "abstract": null, "doi": "10.2196/23712", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-23T07:12:28.728Z", "modified": "2021-02-26T08:47:00.316Z"}, {"entity": "publication", "iuid": "ebceb4aab75b41cf84f88db076202122", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ebceb4aab75b41cf84f88db076202122.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ebceb4aab75b41cf84f88db076202122"}}, "title": "COVID-19, Religious Coping, and Weight Change in the Orthodox Jewish Community.", "authors": [{"family": "Pirutinsky", "given": "Steven", "initials": "S"}, {"family": "Cherniak", "given": "Aaron D", "initials": "AD"}, {"family": "Rosmarin", "given": "David H", "initials": "DH"}], "type": "journal article", "published": "2021-02-21", "journal": {"title": "J Relig Health", "issn": "1573-6571", "volume": null, "issue": null, "issn-l": null}, "abstract": "Given links between stress and obesity, it is likely that individuals gained weight during the COVID-19 lockdown. Research suggests that religiosity facilitates coping, which may have lessened the relationship between stress and weight gain during the COVID-19 lockdown. We examined this relationship among Orthodox Jews (n = 731). Results indicated that stress was marginally associated with weight gain, and that this was moderated by intrinsic religiosity (IR). For those with low IR, stress correlated with weight gain, while for those with mean or higher IR, stress and weight change were unrelated. Results suggest that for some, religiosity may moderate links between stress and weight gain during times of crisis.", "doi": "10.1007/s10943-021-01196-8", "pmid": "33611679", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10943-021-01196-8"}], "notes": [], "created": "2021-02-22T11:50:52.955Z", "modified": "2021-02-26T08:47:00.290Z"}, {"entity": "publication", "iuid": "d17e971be14a4a93a6cff389f61af531", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d17e971be14a4a93a6cff389f61af531.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d17e971be14a4a93a6cff389f61af531"}}, "title": "Separation of power and expertise: Evidence of the tyranny of experts in Sweden's COVID-19 responses.", "authors": [{"family": "Bylund", "given": "Per L", "initials": "PL"}, {"family": "Packard", "given": "Mark D", "initials": "MD"}], "type": "journal article", "published": "2021-02-19", "journal": {"title": "South Econ J", "issn": "0038-4038", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Whereas most countries in the COVID-19 pandemic imposed shutdowns and curfews to mitigate the contagion, Sweden uniquely pursued a more voluntarist approach. In this article, our interest is primarily on how and why Sweden's approach to the pandemic was so unique. There are two parts to this research question: (1) why did virtually all other nations follow a radical lockdown protocol despite limited evidence to its effectiveness and (2) why did Sweden not follow this same protocol despite strong political pressures? The answers to these questions lie within typical government technocracy versus Sweden's constitutional separation of government and technocracy. We review the history of the responses to the pandemic and show how the \"tyranny of experts\" was severe within the typical technocratic policy response, and attenuated in Sweden's. Thus, the recent pandemic offers empirical evidence and insights regarding the role of Hayekian knowledge problems in engendering a technocratic \"tyranny of experts\" and how such effects can be structurally mitigated.", "doi": "10.1002/soej.12493", "pmid": "33821054", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "SOEJ12493"}, {"db": "pmc", "key": "PMC8014802"}], "notes": [], "created": "2021-04-07T10:11:20.636Z", "modified": "2021-04-07T10:11:49.163Z"}, {"entity": "publication", "iuid": "d90e9a3eae6845369c634f138fa5ee49", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d90e9a3eae6845369c634f138fa5ee49.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d90e9a3eae6845369c634f138fa5ee49"}}, "title": "Promoting Mental Health and Well-Being among Adolescent Young Carers in Europe: A Randomized Controlled Trial Protocol.", "authors": [{"family": "Casu", "given": "Giulia", "initials": "G"}, {"family": "Hlebec", "given": "Valentina", "initials": "V"}, {"family": "Boccaletti", "given": "Licia", "initials": "L"}, {"family": "Bolko", "given": "Irena", "initials": "I"}, {"family": "Manattini", "given": "Alessandra", "initials": "A"}, {"family": "Hanson", "given": "Elizabeth", "initials": "E"}], "type": "journal article", "published": "2021-02-19", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "4", "pages": null}, "abstract": "It is estimated that 4-8% of youth in Europe carry out substantial care for a family member or significant other. To prevent adverse psychosocial outcomes in young carers (YCs), primary prevention resilience building interventions have been recommended. We describe the study protocol of an international randomized controlled trial (RCT) of an innovative group intervention designed to promote the mental health and well-being of adolescent YCs (AYCs) aged 15-17. The RCT will be conducted in six European countries in the context of the Horizon 2020 European funded research and innovation project \"Psychosocial support for promoting mental health and well-being among adolescent young caregivers in Europe\" (\"ME-WE\"). The ME-WE intervention is based on Hayes and Ciarrochi's psychoeducational model for adolescents and will consist of seven 2-h sessions in a group format, aimed to help AYCs build psychological flexibility and live according to their values. The control group will be a waitlist. Primary and secondary outcomes and control variables will be measured at baseline (T0), post-intervention (T1) and 3 months follow-up (T2). The COVID-19 pandemic has made amendments necessary to the original study protocol methodology, which we describe in detail. This study will contribute to building an evidence-based manualized program that educators and health and social care professionals can use to support AYCs in their transition to adulthood. From a research perspective, the outcomes of this study will contribute to evidence-based practices in primary prevention of psychosocial difficulties in AYCs and will gather novel knowledge on the effectiveness of Hayes and Ciarrochi's model for use with middle adolescents with caring responsibilities. The trial has been preregistered (registration number: NCT04114864).", "doi": "10.3390/ijerph18042045", "pmid": "33669796", "labels": {"Category: Public Health": null, "Type: Journal article": null, "Funder: H2020": null}, "xrefs": [{"db": "pii", "key": "ijerph18042045"}, {"db": "ClinicalTrials.gov", "key": "NCT04114864"}], "notes": [], "created": "2021-03-08T10:54:03.463Z", "modified": "2021-06-18T12:16:05.877Z"}, {"entity": "publication", "iuid": "681a63ed4b294f4abe9209a1d989d4e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/681a63ed4b294f4abe9209a1d989d4e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/681a63ed4b294f4abe9209a1d989d4e7"}}, "title": "Opposing Vaccine Hesitancy During the Covid-19 Pandemic - A Critical Commentary and United Statement of an International Osteopathic Research Community.", "authors": [{"family": "Thomson", "given": "Oliver P", "initials": "OP"}, {"family": "MacMillan", "given": "Andrew", "initials": "A"}, {"family": "Draper-Rodi", "given": "Jerry", "initials": "J"}, {"family": "Vaucher", "given": "Paul", "initials": "P"}, {"family": "M\u00e9nard", "given": "Mathieu", "initials": "M"}, {"family": "Vaughan", "given": "Brett", "initials": "B"}, {"family": "Morin", "given": "Chantal", "initials": "C"}, {"family": "Alvarez", "given": "Gerard", "initials": "G"}, {"family": "Sampath", "given": "Kesava Kovanur", "initials": "KK"}, {"family": "Cerritelli", "given": "Francesco", "initials": "F"}, {"family": "Shaw", "given": "Robert", "initials": "R"}, {"family": "Cymet", "given": "Tyler C", "initials": "TC"}, {"family": "Bright", "given": "Philip", "initials": "P"}, {"family": "Hohenschurz-Schmidt", "given": "David", "initials": "D"}, {"family": "Vogel", "given": "Steven", "initials": "S"}], "type": "editorial", "published": "2021-02-19", "journal": {"title": "Int J Osteopath Med", "issn": "1746-0689", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.ijosm.2021.02.002", "pmid": "33623534", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1746-0689(21)00005-5"}, {"db": "pmc", "key": "PMC7893309"}], "notes": [], "created": "2021-02-25T10:11:47.768Z", "modified": "2021-02-25T10:11:53.052Z"}, {"entity": "publication", "iuid": "3d38032e50e44e79976f38229ffa6e4f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3d38032e50e44e79976f38229ffa6e4f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3d38032e50e44e79976f38229ffa6e4f"}}, "title": "Notes from afar: reflections from two Australian intensivists in Sweden during the COVID-19 pandemic.", "authors": [{"family": "Chew", "given": "Michelle S", "initials": "MS"}, {"family": "Halliday", "given": "Thomas", "initials": "T"}], "type": "letter", "published": "2021-02-19", "journal": {"title": "Med J Aust", "issn": "1326-5377", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.5694/mja2.50949", "pmid": "33608964", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-22T11:49:45.169Z", "modified": "2021-02-22T11:49:45.191Z"}, {"entity": "publication", "iuid": "6118df012a05421baa922beeefe40c9f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6118df012a05421baa922beeefe40c9f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6118df012a05421baa922beeefe40c9f"}}, "title": "Microsurgery training during COVID-19 pandemic: Practical recommendations from the International Society for Experimental Microsurgery and International Microsurgery Simulation Society.", "authors": [{"family": "Oltean", "given": "Mihai", "initials": "M"}, {"family": "Nistor", "given": "Alexandru", "initials": "A"}, {"family": "Hellstr\u00f6m", "given": "Mats", "initials": "M"}, {"family": "Axelsson", "given": "Michael", "initials": "M"}, {"family": "Yagi", "given": "Shintaro", "initials": "S"}, {"family": "Kobayashi", "given": "Eiji", "initials": "E"}, {"family": "Ballestin", "given": "Alberto", "initials": "A"}, {"family": "Akelina", "given": "Yelena", "initials": "Y"}, {"family": "Nemeth", "given": "Norbert", "initials": "N"}], "type": "editorial", "published": "2021-02-19", "journal": {"title": "Microsurgery", "issn": "1098-2752", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1002/micr.30725", "pmid": "33606305", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-22T11:47:59.892Z", "modified": "2021-02-22T11:49:22.216Z"}, {"entity": "publication", "iuid": "a7817eb57bdf490c9e490c19a8dabe4f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7817eb57bdf490c9e490c19a8dabe4f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7817eb57bdf490c9e490c19a8dabe4f"}}, "title": "Different disease, same challenges: Social determinants of tuberculosis and COVID-19.", "authors": [{"family": "Duarte", "given": "R", "initials": "R"}, {"family": "Aguiar", "given": "A", "initials": "A"}, {"family": "Pinto", "given": "M", "initials": "M"}, {"family": "Furtado", "given": "I", "initials": "I"}, {"family": "Tiberi", "given": "S", "initials": "S"}, {"family": "L\u00f6nnroth", "given": "K", "initials": "K"}, {"family": "Migliori", "given": "G B", "initials": "GB"}], "type": "journal article", "published": "2021-02-19", "journal": {"title": "Pulmonology", "issn": "2531-0437", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Infectious diseases, such as tuberculosis (TB) and the novel coronavirus (COVID-19) relate to environmental factors, understanding of which is essential to inform policy and practice and tackle them effectively. The review follows the conceptual framework offered by the World Health Organization Commission on Social Determinants of Health (defined as \"all those material, psychological and behavioural circumstances linked to health and generically indicated as risk factors' in the conventional epidemiological language\"). It describes the social factors behind TB and COVID-19, the commonalities between the two diseases, and what can be learned so far from the published best practices. The social determinants sustaining TB and COVID-19 underline the importance of prioritising health and allocating adequate financial and human resources to achieve universal health coverage and health-related social protection while addressing the needs of vulnerable populations. Rapid and effective measures against poverty and other major social determinants and sources of inequality are urgently needed to develop better health in the post-COVID-19 world.", "doi": "10.1016/j.pulmoe.2021.02.002", "pmid": "33648891", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S2531-0437(21)00048-9"}], "notes": [], "created": "2021-03-03T17:00:21.196Z", "modified": "2021-06-18T12:27:09.827Z"}, {"entity": "publication", "iuid": "51a1f0cc535542d8a7e55dbdad9731ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/51a1f0cc535542d8a7e55dbdad9731ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/51a1f0cc535542d8a7e55dbdad9731ef"}}, "title": "COVID-19: From health crises to food security anxiety and policy implications.", "authors": [{"family": "Chiwona-Karltun", "given": "Linley", "initials": "L"}, {"family": "Amuakwa-Mensah", "given": "Franklin", "initials": "F"}, {"family": "Wamala-Larsson", "given": "Caroline", "initials": "C"}, {"family": "Amuakwa-Mensah", "given": "Salome", "initials": "S"}, {"family": "Abu Hatab", "given": "Assem", "initials": "A"}, {"family": "Made", "given": "Nolwandle", "initials": "N"}, {"family": "Taremwa", "given": "Nathan Kanuma", "initials": "NK"}, {"family": "Melyoki", "given": "Lemayon", "initials": "L"}, {"family": "Rutashobya", "given": "Lettice Kinunda", "initials": "LK"}, {"family": "Madonsela", "given": "Thulisile", "initials": "T"}, {"family": "Lourens", "given": "Marna", "initials": "M"}, {"family": "Stone", "given": "Wendy", "initials": "W"}, {"family": "Bizoza", "given": "Alfred R", "initials": "AR"}], "type": "journal article", "published": "2021-02-19", "journal": {"title": "Ambio", "issn": "1654-7209", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Like the rest of the world, African countries are reeling from the health, economic and social effects of COVID-19. The continent's governments have responded by imposing rigorous lockdowns to limit the spread of the virus. The various lockdown measures are undermining food security, because stay at home orders have among others, threatened food production for a continent that relies heavily on agriculture as the bedrock of the economy. This article draws on quantitative data collected by the GeoPoll, and, from these data, assesses the effect of concern about the local spread and economic impact of COVID-19 on food worries. Qualitative data comprising 12 countries south of the Sahara reveal that lockdowns have created anxiety over food security as a health, economic and human rights/well-being issue. By applying a probit model, we find that concern about the local spread of COVID-19 and economic impact of the virus increases the probability of food worries. Governments have responded with various efforts to support the neediest. By evaluating the various policies rolled out we advocate for a feminist economics approach that necessitates greater use of data analytics to predict the likely impacts of intended regulatory relief responses during the recovery process and post-COVID-19.", "doi": "10.1007/s13280-020-01481-y", "pmid": "33606247", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s13280-020-01481-y"}], "notes": [], "created": "2021-02-22T11:45:22.176Z", "modified": "2021-06-18T12:28:21.236Z"}, {"entity": "publication", "iuid": "67a263a9b3b24ca9bf17cf8e24179ae6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/67a263a9b3b24ca9bf17cf8e24179ae6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/67a263a9b3b24ca9bf17cf8e24179ae6"}}, "title": "Transparency in Negotiation of European Union With Big Pharma on COVID-19 Vaccines.", "authors": [{"family": "Sciacchitano", "given": "Salvatore", "initials": "S"}, {"family": "Bartolazzi", "given": "Armando", "initials": "A"}], "type": "journal article", "published": "2021-02-18", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "issue": null, "pages": "647955", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2021.647955", "pmid": "33681138", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7930234"}], "notes": [], "created": "2021-03-09T15:35:17.044Z", "modified": "2021-03-09T15:38:10.721Z"}, {"entity": "publication", "iuid": "c811df8a6c9740759e2469610833548b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c811df8a6c9740759e2469610833548b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c811df8a6c9740759e2469610833548b"}}, "title": "Primary Immunodeficiencies: A Decade of Progress and a Promising Future.", "authors": [{"family": "Meyts", "given": "Isabelle", "initials": "I"}, {"family": "Bousfiha", "given": "Aziz", "initials": "A"}, {"family": "Duff", "given": "Carla", "initials": "C"}, {"family": "Singh", "given": "Surjit", "initials": "S"}, {"family": "Lau", "given": "Yu Lung", "initials": "YL"}, {"family": "Condino-Neto", "given": "Antonio", "initials": "A"}, {"family": "Bezrodnik", "given": "Liliana", "initials": "L"}, {"family": "Ali", "given": "Adli", "initials": "A"}, {"family": "Adeli", "given": "Mehdi", "initials": "M"}, {"family": "Drabwell", "given": "Jose", "initials": "J"}], "type": "journal article", "published": "2021-02-18", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "11", "issue": null, "pages": "625753", "issn-l": "1664-3224"}, "abstract": null, "doi": "10.3389/fimmu.2020.625753", "pmid": "33679719", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7935502"}], "notes": [], "created": "2021-03-09T15:37:08.145Z", "modified": "2021-03-09T15:37:08.155Z"}, {"entity": "publication", "iuid": "4262013c82c143d8991de666f365484f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4262013c82c143d8991de666f365484f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4262013c82c143d8991de666f365484f"}}, "title": "Open Schools, Covid-19, and Child and Teacher Morbidity in Sweden.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF", "orcid": "0000-0003-1024-5602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1d5e45881a7469ca20a0eb360d891cc.json"}}, {"family": "Engerstr\u00f6m", "given": "Lars", "initials": "L"}, {"family": "Nordenh\u00e4ll", "given": "Charlotta", "initials": "C"}, {"family": "Larsson", "given": "Emma", "initials": "E"}], "type": "letter", "published": "2021-02-18", "journal": {"title": "N Engl J Med", "issn": "1533-4406", "issn-l": null, "volume": "384", "issue": "7", "pages": "669-671"}, "abstract": "Letter to Editor", "doi": "10.1056/NEJMc2026670", "pmid": "33406327", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7821981"}], "notes": [], "created": "2021-01-07T09:53:32.558Z", "modified": "2023-01-05T09:34:44.061Z"}, {"entity": "publication", "iuid": "dbba08ac3a844ce3a632411d77f7c4f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dbba08ac3a844ce3a632411d77f7c4f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dbba08ac3a844ce3a632411d77f7c4f0"}}, "title": "Mortality of the COVID-19 Outbreak in Sweden in Relation to Previous Severe Disease Outbreaks.", "authors": [{"family": "Ledberg", "given": "Anders", "initials": "A"}], "type": "historical article", "published": "2021-02-18", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "9", "issue": null, "pages": "579948", "issn-l": "2296-2565"}, "abstract": "Influenza viruses have caused disease outbreaks in human societies for a long time. Influenza often has rapid onset and relatively short duration, both in the individual and in the population. The case fatality rate varies for different strains of the virus, as do the effects on total mortality. Outbreaks related to coronavirus infections have recently become a global concern but much less is known about the dynamics of these outbreaks and their effects on mortality. In this work, disease outbreaks in Sweden, in the time period of 1860-2020, are characterized and compared to the currently ongoing COVID-19 outbreak. The focus is on outbreaks with a sharp increase in all-cause mortality. Outbreak onset is defined as the time point when death counts start to increase consistently for a period of at least 10 days. The duration of the outbreak is defined as the time period in which mortality rates are elevated. Excess mortality is estimated by standard methods. In total there were 15 outbreaks detected in the time period, the first 14 were likely caused by influenza virus infections, the last by SARS-CoV-2. The mortality dynamics of the SARS-CoV-2 outbreak is shown to be similar to outbreaks due to influenza virus, and in terms of the number of excess deaths, it is the worst outbreak in Sweden since the \"Spanish flu\" of 1918-1919.", "doi": "10.3389/fpubh.2021.579948", "pmid": "33681118", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7930003"}], "notes": [], "created": "2021-03-09T15:34:43.443Z", "modified": "2023-01-13T14:42:10.712Z"}, {"entity": "publication", "iuid": "56fe137526f642b09109307e1e3d002c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56fe137526f642b09109307e1e3d002c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56fe137526f642b09109307e1e3d002c"}}, "title": "COVID-19: A methyl-group assault?", "authors": [{"family": "McCaddon", "given": "Andrew", "initials": "A"}, {"family": "Regland", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2021-02-18", "journal": {"title": "Med Hypotheses", "issn": "1532-2777", "volume": "149", "issue": null, "pages": "110543", "issn-l": null}, "abstract": "The socio-economic implications of COVID-19 are devastating. Considerable morbidity is attributed to 'long-COVID' - an increasingly recognized complication of infection. Its diverse symptoms are reminiscent of vitamin B 12 deficiency, a condition in which methylation status is compromised. We suggest why SARS-CoV-2 infection likely leads to increased methyl-group requirements and other disturbances of one-carbon metabolism. We propose these might explain the varied symptoms of long-COVID. Our suggested mechanismmight also apply to similar conditions such as myalgic encephalomyelitis/chronic fatigue syndrome. The hypothesis is evaluable by detailed determination of vitamin B12and folate status, including serum formate as well as homocysteine and methylmalonic acid, and correlation with viral and host RNA methylation and symptomatology. If confirmed, methyl-group support should prove beneficial in such individuals.", "doi": "10.1016/j.mehy.2021.110543", "pmid": "33657459", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0306-9877(21)00061-X"}], "notes": [], "created": "2021-03-04T14:56:44.491Z", "modified": "2021-03-04T14:56:44.501Z"}, {"entity": "publication", "iuid": "2776c89c8fbb490faa3383929ae5e355", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2776c89c8fbb490faa3383929ae5e355.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2776c89c8fbb490faa3383929ae5e355"}}, "title": "No Apparent Increase in Treatment Uptake for Gambling Disorder during Ten Months of the COVID-19 Pandemic-Analysis of a Regional Specialized Treatment Unit in Sweden.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "\u00c5kesson", "given": "Gunny", "initials": "G"}, {"family": "Grudet", "given": "C\u00e9cile", "initials": "C"}, {"family": "Broman", "given": "Niroshani", "initials": "N"}], "type": "journal article", "published": "2021-02-17", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "4", "pages": null}, "abstract": "The COVID-19 pandemic and its impact on society has been suspected to affect gambling behaviors. Potentially, the pandemic crisis may result in increased problem gambling, for example, due to COVID-19-related psychological distress, unemployment, and financial difficulties. In addition, the cancellation of sports in early parts of the crisis has been suspected to alter gambling behaviors. Policy makers have called for action and, in some cases, have changed regulations, and media have reported possible increases in treatment seeking. However, research data are hitherto lacking. The present study assessed the treatment uptake at a regional specialized gambling-disorder unit in the healthcare system of Region Sk\u00e5ne, Sweden. Number of patients, treatment contacts, and patterns of rescheduling or cancellations of appointments were quantified for each month, January-December 2020, and compared to corresponding months of 2018 and 2019. Possible trends were analyzed, using an interrupted time-series analysis. Results did not indicate an increase in treatment uptake for gambling disorder during the months of COVID-19 impact in Sweden. The proportion of digital treatment increased, but total treatment uptake was unaffected by the pandemic. In conclusion, during the first ten months of the pandemic in Sweden, no obvious increase in treatment uptake for gambling disorder could be seen. Moreover, longer follow-up may be necessary in order to see if effects of worsening socioeconomic conditions may be a possible long-term risk factor of increased gambling after COVID-19.", "doi": "10.3390/ijerph18041918", "pmid": "33671210", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph18041918"}], "notes": [], "created": "2021-03-08T10:55:33.867Z", "modified": "2021-06-18T12:13:22.550Z"}, {"entity": "publication", "iuid": "4fd3a6db29284949ba20ab51f116fca8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4fd3a6db29284949ba20ab51f116fca8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4fd3a6db29284949ba20ab51f116fca8"}}, "title": "Impacts of COVID-19 on long-term health and health care use", "authors": [{"family": "Skyrud", "given": "Katrine", "initials": "K", "orcid": "0000-0001-7504-9253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa7b45c41c544ba098093febd55117c8.json"}}, {"family": "Hern\u00e6s", "given": "Kjersti Helene", "initials": "KH"}, {"family": "Telle", "given": "Kjetil", "initials": "K", "orcid": "0000-0002-7978-0825", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/21c273a80c5c4976bd93f15f2e038f40.json"}}, {"family": "Magnusson", "given": "Karin", "initials": "K", "orcid": "0000-0003-4851-5794", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2fe6a28f36f40a998b8c9fc3c5ebe73.json"}}], "type": "posted-content", "published": "2021-02-17", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.16.21251807", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-18T11:03:10.874Z", "modified": "2022-11-22T05:53:14.152Z"}, {"entity": "publication", "iuid": "c5613dca3ecd449180e010846b313144", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5613dca3ecd449180e010846b313144.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5613dca3ecd449180e010846b313144"}}, "title": "Association between cardiometabolic disease and severe COVID-19: a nationwide case-control study of patients requiring invasive mechanical ventilation.", "authors": [{"family": "Svensson", "given": "Per", "initials": "P"}, {"family": "Hofmann", "given": "Robin", "initials": "R"}, {"family": "H\u00e4bel", "given": "Henrike", "initials": "H"}, {"family": "Jernberg", "given": "Tomas", "initials": "T"}, {"family": "Nordberg", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2021-02-17", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "11", "issue": "2", "pages": "e044486"}, "abstract": "The risks associated with diabetes, obesity and hypertension for severe COVID-19 may be confounded and differ by sociodemographic background. We assessed the risks associated with cardiometabolic factors for severe COVID-19 when accounting for socioeconomic factors and in subgroups by age, sex and region of birth.\r\n\r\nIn this nationwide case-control study, 1.086 patients admitted to intensive care with COVID-19 requiring mechanical ventilation (cases), and 10.860 population-based controls matched for age, sex and district of residency were included from mandatory national registries. ORs with 95% CIs for associations between severe COVID-19 and exposures with adjustment for confounders were estimated using logistic regression. The median age was 62 years (IQR 52-70), and 3003 (24.9%) were women. Type 2 diabetes (OR, 2.3 (95% CI 1.9 to 2.7)), hypertension (OR, 1.7 (95% CI 1.5 to 2.0)), obesity (OR, 3.1 (95% CI 2.4 to 4.0)) and chronic kidney disease (OR, 2.5 (95% CI 1.7 to 3.7)) were all associated with severe COVID-19. In the younger subgroup (below 57 years), ORs were significantly higher for all cardiometabolic risk factors. The risk associated with type 2 diabetes was higher in women (p=0.001) and in patients with a region of birth outside European Union(EU) (p=0.004).\r\n\r\nDiabetes, obesity and hypertension were all independently associated with severe COVID-19 with stronger associations in the younger population. Type 2 diabetes implied a greater risk among women and in non-EU immigrants. These findings, originating from high-quality Swedish registries, may be important to direct preventive measures such as vaccination to susceptible patient groups.\r\n\r\nClinicaltrial.gov (NCT04426084).", "doi": "10.1136/bmjopen-2020-044486", "pmid": "33597145", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-044486"}, {"db": "ClinicalTrials.gov", "key": "NCT04426084"}], "notes": [], "created": "2021-02-19T06:22:45.933Z", "modified": "2021-06-18T12:06:53.712Z"}, {"entity": "publication", "iuid": "4b0f1b1ea560426c8ef9e4bb44326d3f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b0f1b1ea560426c8ef9e4bb44326d3f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b0f1b1ea560426c8ef9e4bb44326d3f"}}, "title": "Extracorporeal Life Support in COVID-19-related Acute Respiratory Distress Syndrome - a EuroELSO international survey.", "authors": [{"family": "Mang", "given": "Sebastian", "initials": "S"}, {"family": "Kalenka", "given": "Armin", "initials": "A"}, {"family": "Broman", "given": "Lars Mikael", "initials": "LM"}, {"family": "Supady", "given": "Alexander", "initials": "A"}, {"family": "Swol", "given": "Justyna", "initials": "J"}, {"family": "Danziger", "given": "Guy", "initials": "G"}, {"family": "Becker", "given": "Andr\u00e9", "initials": "A"}, {"family": "H\u00f6rsch", "given": "Sabrina I", "initials": "SI"}, {"family": "Mertke", "given": "Thilo", "initials": "T"}, {"family": "Kaiser", "given": "Ralf", "initials": "R"}, {"family": "Bracht", "given": "Hendrik", "initials": "H"}, {"family": "Zotzmann", "given": "Viviane", "initials": "V"}, {"family": "Seiler", "given": "Frederik", "initials": "F"}, {"family": "Bals", "given": "Robert", "initials": "R"}, {"family": "Taccone", "given": "Fabio Silvio", "initials": "FS"}, {"family": "Moerer", "given": "Onnen", "initials": "O"}, {"family": "Lorusso", "given": "Roberto", "initials": "R"}, {"family": "B\u011blohl\u00e1vek", "given": "Jan", "initials": "J"}, {"family": "Muellenbach", "given": "Ralf M", "initials": "RM"}, {"family": "Lepper", "given": "Philipp M", "initials": "PM"}, {"family": "COVEC-Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-02-16", "journal": {"title": "Artif Organs", "issn": "1525-1594", "volume": null, "issue": null, "issn-l": null}, "abstract": "Extracorporeal life support (ECLS) is a means to support patients with acute respiratory failure. Initially, recommendations to treat severe cases of pandemic Coronavirus Disease 2019 (COVID-19) with ECLS have been restrained. In the meantime, ECLS has been shown to produce similar outcomes in patients with severe COVID-19 compared to existing data on ARDS mortality.\n\nWe performed an international email survey to assess how ECLS providers worldwide have previously used ECLS during the treatment of critically ill patients with COVID-19.\n\nA questionnaire with 45 questions (covering e.g. indication, technical aspects, benefit and reasons for treatment discontinuation), mostly multiple-choice, was distributed by email to ECLS centers. The survey was approved by the European branch of the Extracorporeal Life Support Organization (ELSO).\n\n276 ECMO professionals from 98 centers in 30 different countries on four continents reported that they employed ECMO for very severe COVID-19 cases, mostly in veno-venous configuration (87%). The most common reason to establish ECLS was isolated hypoxemic respiratory failure (50%), followed by a combination of hypoxemia and hypercapnia (39%). Only a small fraction of patients required veno-arterial cannulation due to heart failure (3%). Time on ECLS varied between less than two and more than four weeks. The main reason to discontinue ECLS treatment prior to patient's recovery was lack of clinical improvement (53%), followed by major bleeding, mostly intracranially (13%). Only 4% of respondents reported that triage situations, lack of staff or lack of oxygenators were responsible for discontinuation of ECLS support. Most ECLS physicians (51%, IQR 30%) agreed that patients with COVID-19 induced ARDS (CARDS) benefitted from ECLS. Overall mortality of COVID-19 patients on ECLS was estimated to be about 55%.\n\nECLS has been utilized successfully during the COVID-19 pandemic to stabilize CARDS patients in hypoxemic or hypercapnic lung failure. Age and multimorbidity limited the use of ECLS. Triage situations were rarely a concern. ECLS providers stated that patients with severe COVID-19 benefitted from ECLS.", "doi": "10.1111/aor.13940", "pmid": "33590542", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-02-17T15:04:16.789Z", "modified": "2021-02-17T15:05:18.711Z"}, {"entity": "publication", "iuid": "93685b21b5ce4554bb28daffb4ac1ddb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/93685b21b5ce4554bb28daffb4ac1ddb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/93685b21b5ce4554bb28daffb4ac1ddb"}}, "title": "SARS-CoV2 envelop proteins reshape the serological responses of COVID-19 patients", "authors": [{"family": "Martin", "given": "Sophie", "initials": "S"}, {"family": "Heslan", "given": "Christopher", "initials": "C"}, {"family": "Jegou", "given": "Gwenaele", "initials": "G"}, {"family": "Eriksson", "given": "Leif A", "initials": "LA"}, {"family": "Le Gallo", "given": "Matthieu", "initials": "M"}, {"family": "Thibault", "given": "Vincent", "initials": "V"}, {"family": "Chevet", "given": "Eric", "initials": "E"}, {"family": "Avril", "given": "Tony", "initials": "T"}], "type": "posted-content", "published": "2021-02-15", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.15.431237", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-02-16T15:10:29.773Z", "modified": "2021-03-08T15:06:49.441Z"}, {"entity": "publication", "iuid": "b958e83e0e8d45cfa85481fec9b4d055", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b958e83e0e8d45cfa85481fec9b4d055.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b958e83e0e8d45cfa85481fec9b4d055"}}, "title": "Identification of endothelial-derived proteins in plasma associated with cardiovascular risk factors", "authors": [{"family": "Iglesias", "given": "MJ", "initials": "M"}, {"family": "LD", "given": "Kruse", "initials": "K"}, {"family": "Sanchez-Rivera", "given": "L", "initials": "L"}, {"family": "Enge", "given": "L", "initials": "L"}, {"family": "Dusart", "given": "P", "initials": "P"}, {"family": "Hong", "given": "MG", "initials": "M"}, {"family": "M Uhl\u00e9n", "given": "M", "initials": "M"}, {"family": "Renn\u00e9", "given": "T", "initials": "T"}, {"family": "Schwenk", "given": "JM", "initials": "J"}, {"family": "Bergstrom", "given": "G", "initials": "G"}, {"family": "Odeberg", "given": "J", "initials": "J"}, {"family": "Butler", "given": "LM", "initials": "L"}], "type": null, "published": "2021-02-15", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "https://doi.org/10.1101/2021.02.08.21251209", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-15T18:28:29.299Z", "modified": "2021-02-26T08:45:48.606Z"}, {"entity": "publication", "iuid": "27d452f2a66c49e18ad440c11fbe7456", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27d452f2a66c49e18ad440c11fbe7456.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27d452f2a66c49e18ad440c11fbe7456"}}, "title": "European Task Force on Atopic Dermatitis (ETFAD): position on vaccination of adult patients with atopic dermatitis against COVID-19 (SARS-CoV-2) being treated with systemic medication and biologics.", "authors": [{"family": "Thyssen", "given": "Jacob P", "initials": "JP"}, {"family": "Vestergaard", "given": "Christian", "initials": "C"}, {"family": "Barbarot", "given": "Sebastien", "initials": "S"}, {"family": "de Bruin-Weller", "given": "Marjolein S", "initials": "MS"}, {"family": "Bieber", "given": "Thomas", "initials": "T"}, {"family": "Taieb", "given": "Alain", "initials": "A"}, {"family": "Seneschal", "given": "Julien", "initials": "J"}, {"family": "Cork", "given": "Michael J", "initials": "MJ"}, {"family": "Paul", "given": "Carle", "initials": "C"}, {"family": "Flohr", "given": "Carsten", "initials": "C"}, {"family": "Weidinger", "given": "Stephan", "initials": "S"}, {"family": "Trzeciak", "given": "Magdalena", "initials": "M"}, {"family": "Werfel", "given": "Thomas", "initials": "T"}, {"family": "Heratizadeh", "given": "Annice", "initials": "A"}, {"family": "Darsow", "given": "Ulf", "initials": "U"}, {"family": "Simon", "given": "Dagmar", "initials": "D"}, {"family": "Torrelo", "given": "Antonio", "initials": "A"}, {"family": "Chernyshov", "given": "Pavel V", "initials": "PV"}, {"family": "Stalder", "given": "Jean-Francois", "initials": "J"}, {"family": "Gelmetti", "given": "Carlo", "initials": "C"}, {"family": "Szalai", "given": "Zsuzsanna", "initials": "Z"}, {"family": "Svensson", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "von Kobyletzki", "given": "Laura B", "initials": "LB"}, {"family": "De Raeve", "given": "Linda", "initials": "L"}, {"family": "F\u00f6lster-Holst", "given": "Regina", "initials": "R"}, {"family": "Christen-Zaech", "given": "St\u00e9phanie", "initials": "S"}, {"family": "Jan Hijnen", "given": "Dirk", "initials": "D"}, {"family": "Gieler", "given": "Uwe", "initials": "U"}, {"family": "Gutermuth", "given": "Jan", "initials": "J"}, {"family": "Bangert", "given": "Christine", "initials": "C"}, {"family": "Spuls", "given": "Phyllis I", "initials": "PI"}, {"family": "Kunz", "given": "Barbara", "initials": "B"}, {"family": "Ring", "given": "Johannes", "initials": "J"}, {"family": "Wollenberg", "given": "Andreas", "initials": "A"}, {"family": "Deleuran", "given": "Mette", "initials": "M"}], "type": "journal article", "published": "2021-02-15", "journal": {"title": "J Eur Acad Dermatol Venereol", "issn": "1468-3083", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic is caused by rapid spread of different strains of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The severity of infection ranges from mild, or even asymptomatic, to very severe. Signs and symptoms include fatigue, fever, exanthemas, upper respiratory illness, loss of smell and taste, pneumonia, severe acute respiratory syndrome, and multi-organ failure. Risk factors for a severe or lethal course include age, male gender, obesity, diabetes, cardiovascular disease, and immune suppression 1 .", "doi": "10.1111/jdv.17167", "pmid": "33587756", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-17T14:50:53.614Z", "modified": "2021-02-17T14:51:23.369Z"}, {"entity": "publication", "iuid": "b70af2764edf45d598cb8546b2df3aec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b70af2764edf45d598cb8546b2df3aec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b70af2764edf45d598cb8546b2df3aec"}}, "title": "Comprehensive Landscape of Heparin Therapy for COVID-19.", "authors": [{"family": "Shi", "given": "Chen", "initials": "C"}, {"family": "Tingting", "given": "Wu", "initials": "W"}, {"family": "Li", "given": "Jin-Ping", "initials": "JP"}, {"family": "Sullivan", "given": "Mitchell A", "initials": "MA"}, {"family": "Wang", "given": "Cong", "initials": "C"}, {"family": "Wang", "given": "Hanxiang", "initials": "H"}, {"family": "Deng", "given": "Bin", "initials": "B"}, {"family": "Zhang", "given": "Yu", "initials": "Y"}], "type": "journal article", "published": "2021-02-15", "journal": {"title": "Carbohydr Polym", "issn": "1879-1344", "issn-l": null, "volume": "254", "issue": null, "pages": "117232"}, "abstract": "The pandemic coronavirus disease 2019 (COVID-19), caused by the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading globally. Clinical observations found that systemic symptoms caused by SARS-CoV-2 infection are attenuated when using the anticoagulant agent heparin, indicating that heparin may play other roles in managing COVID-19, in addition to prevention of pulmonary thrombosis. Several biochemical studies show strong binding of heparin and heparin-like molecules to the Spike protein, which resulted in inhibition of viral infection to cells. The clinical observations and in vitro studies argue for a potential multiple-targeting effects of heparin. However, adverse effects of heparin administration and some of the challenges using heparin therapy for SARS-CoV-2 infection need to be considered. This review discusses the pharmacological mechanisms of heparin regarding its anticoagulant, anti-inflammatory and direct antiviral activities, providing current evidence concerning the effectiveness and safety of heparin therapy for this major public health emergency.", "doi": "10.1016/j.carbpol.2020.117232", "pmid": "33357843", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7581413"}, {"db": "pii", "key": "S0144-8617(20)31405-3"}], "notes": [], "created": "2021-01-10T17:29:41.591Z", "modified": "2023-06-19T15:36:36.473Z"}, {"entity": "publication", "iuid": "672f02017ba74c67be57dbacfb81707b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/672f02017ba74c67be57dbacfb81707b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/672f02017ba74c67be57dbacfb81707b"}}, "title": "Single-cell sequencing of plasma cells from COVID-19 patients reveals highly expanded clonal lineages produce specific and neutralizing antibodies to SARS-CoV-2", "authors": [{"family": "Ehling", "given": "Roy A", "initials": "RA"}, {"family": "Weber", "given": "C\u00e9dric R", "initials": "CR"}, {"family": "Mason", "given": "Derek M", "initials": "DM"}, {"family": "Friedensohn", "given": "Simon", "initials": "S"}, {"family": "Wagner", "given": "Bastian", "initials": "B"}, {"family": "Bieberich", "given": "Florian", "initials": "F"}, {"family": "Kapetanovic", "given": "Edo", "initials": "E"}, {"family": "Vazquez-Lombardi", "given": "Rodrigo", "initials": "R"}, {"family": "Di Roberto", "given": "Rapha\u00ebl B", "initials": "RB"}, {"family": "Hong", "given": "Kai Lin", "initials": "KL"}, {"family": "Wagner", "given": "Camille", "initials": "C"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Yermanos", "given": "Alexander", "initials": "A"}, {"family": "Cuny", "given": "Andreas P", "initials": "AP"}, {"family": "Savic", "given": "Miodrag", "initials": "M"}, {"family": "Rudolf", "given": "Fabian", "initials": "F"}, {"family": "Reddy", "given": "Sai T", "initials": "ST"}], "type": "posted-content", "published": "2021-02-12", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.12.430940", "pmid": null, "labels": {"Funder: H2020": null, "Category: Biochemistry": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-03-08T15:10:05.611Z", "modified": "2021-03-09T12:31:31.351Z"}, {"entity": "publication", "iuid": "2e8684b503454348aaab5858f9790222", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e8684b503454348aaab5858f9790222.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e8684b503454348aaab5858f9790222"}}, "title": "Quantifying the preventive effect of wearing face masks", "authors": [{"family": "Britton", "given": "Tom", "initials": "T"}], "type": "posted-content", "published": "2021-02-12", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.09.21251448", "pmid": null, "labels": {"Type: Preprint": null, "Funder: NordForsk": null, "Category: Health": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-15T18:30:28.164Z", "modified": "2021-02-26T08:46:13.012Z"}, {"entity": "publication", "iuid": "55ad8ca80a844ef99d92fc0f73089a41", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/55ad8ca80a844ef99d92fc0f73089a41.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/55ad8ca80a844ef99d92fc0f73089a41"}}, "title": "Changes in Lifestyle, Behaviors, and Risk Factors for Cognitive Impairment in Older Persons During the First Wave of the Coronavirus Disease 2019 Pandemic in Finland: Results From the FINGER Study.", "authors": [{"family": "Lehtisalo", "given": "Jenni", "initials": "J"}, {"family": "Palmer", "given": "Katie", "initials": "K"}, {"family": "Mangialasche", "given": "Francesca", "initials": "F"}, {"family": "Solomon", "given": "Alina", "initials": "A"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Ngandu", "given": "Tiia", "initials": "T"}], "type": "journal article", "published": "2021-02-12", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "issue": null, "pages": "624125", "issn-l": "1664-0640"}, "abstract": "Aims: This study aimed to describe how the first phase of the coronavirus disease 2019 (COVID-19) pandemic affected older persons from the general Finnish population who are at risk of developing or have cognitive impairment, specifically, to describe whether participants experienced a change in risk factors that are relevant for the prevention of cognitive decline including diet, physical activity, access to medical care, socially and cognitively stimulating activities, and emotional health and well-being. Method: A postal survey was sent in June 2020 to 859 participants from the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), an ongoing longitudinal study. The survey was developed to assess the effect of the COVID-19 pandemic and related infection-control measures on daily life, specifically commitment to distancing measures, access to health care and social services, daily activities, and changes in cognitive and social activities. Results: By September 2020, 613 (71%) participants responded (mean age = 77.7 years, 32% lived alone, and 80% had at least one chronic condition). Three quarters adopted some distancing practices during the first months of the pandemic. Older participants were more likely to practice total isolation than younger ones (29 vs. 19%; p = 0.003). Non-acute health-care visits were canceled for 5% of the participants who needed appointments, but cancellations in dental health care (43%), home aid (30%), and rehabilitative services (53%) were more common. Pandemic-related changes were reported in social engagements, for example, less contact with friends (55%) and family (31%), or less frequent attendance in cultural events (38%) or associations (25%), although remote contact with others increased for 40%. Feelings of loneliness increased for 21%, particularly those who were older (p = 0.023) or living alone (p < 0.001). Physical activity reduced for 34%, but dietary habits remained stable or improved. Pandemic-related changes in lifestyle and activities were more evident among those living alone. Conclusions: Finnish older persons generally reported less negative changes in lifestyles and behaviors during the pandemic than expected. Older people and those living alone seemed more susceptible to negative changes. It is important to compare how coping strategies may compare with other European countries to identify factors that may help older individuals to maintain healthy lifestyles during future waves of COVID-19.", "doi": "10.3389/fpsyt.2021.624125", "pmid": "33643095", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC7907420"}], "notes": [], "created": "2021-03-02T06:52:05.714Z", "modified": "2021-03-02T06:52:05.717Z"}, {"entity": "publication", "iuid": "d1d6dd596f3249b8bac66ef8ae32e8ec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1d6dd596f3249b8bac66ef8ae32e8ec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1d6dd596f3249b8bac66ef8ae32e8ec"}}, "title": "Tropism of SARS-CoV-2 in commonly used laboratory cell lines and their proteomic landscape during infection", "authors": [{"family": "Elisa Saccon", "given": "", "initials": ""}, {"family": "Xi Chen", "given": ".", "initials": "."}, {"family": "Flora Mikaeloff", "given": "", "initials": ""}, {"family": "jimmy Esneider Rodriguez", "given": "", "initials": ""}, {"family": "Laszlo Szekely", "given": "", "initials": ""}, {"family": "Beatriz S\u00e1 Vinhas", "given": "", "initials": ""}, {"family": "shuba Krishnan", "given": "", "initials": ""}, {"family": "Siddappa N. Byrareddy", "given": "", "initials": ""}, {"family": "Teresa Frisan", "given": "", "initials": ""}, {"family": "\u00c1kos V\u00e9gv\u00e1ri", "given": "", "initials": ""}, {"family": "Ali Mirazimi", "given": "UM", "initials": "U"}, {"family": "ujjwal Neogi", "given": "", "initials": ""}, {"family": "Gupta", "given": "Soham", "initials": "S"}], "type": "posted-content", "published": "2021-02-11", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.08.28.271684", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-02-11T15:56:44.718Z", "modified": "2021-04-23T15:15:50.301Z"}, {"entity": "publication", "iuid": "b335292c5a9a433691ef0b36bf1a765b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b335292c5a9a433691ef0b36bf1a765b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b335292c5a9a433691ef0b36bf1a765b"}}, "title": "Mechanistic and Therapeutic Implications of Extracellular Vesicles as a Potential Link Between Covid-19 and Cardiovascular Disease Manifestations.", "authors": [{"family": "Pironti", "given": "Gianluigi", "initials": "G"}, {"family": "Andersson", "given": "Daniel C", "initials": "DC"}, {"family": "Lund", "given": "Lars H", "initials": "LH"}], "type": "journal article", "published": "2021-02-11", "journal": {"title": "Front Cell Dev Biol", "issn": "2296-634X", "issn-l": null, "volume": "9", "issue": null, "pages": "640723"}, "abstract": "Extracellular vesicles (EVs), which are cell released double layered membrane particles, have been found in every circulating body fluid, and provide a tool for conveying diverse information between cells, influencing both physiological and pathological conditions. Viruses can hijack the EVs secretory pathway to exit infected cells and use EVs endocytic routes to enter uninfected cells, suggesting that EVs and viruses can share common cell entry and biogenesis mechanisms. SARS-CoV-2 is responsible of the coronavirus disease 2019 (Covid-19), which may be accompanied by severe multi-organ manifestations. EVs may contribute to virus spreading via transfer of virus docking receptors such as CD9 and ACE2. Covid-19 is known to affect the renin angiotensin system (RAS), and could promote secretion of harmful EVs. In this scenario EVs might be linked to cardiovascular manifestations of the Covid-19 disease through unbalance in RAS. In contrast EVs derived from mesenchymal stem cells or cardiosphere derived cells, may promote cardiovascular function due to their beneficial effect on angiogenesis, fibrosis, contractility and immuno-modulation. In this article we assessed the potential impact of EVs in cardiovascular manifestations of Covid-19 and highlight potential strategies to control the extracellular signaling for future therapies.", "doi": "10.3389/fcell.2021.640723", "pmid": "33644077", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7905102"}], "notes": [], "created": "2021-03-02T06:55:09.771Z", "modified": "2021-06-18T11:56:14.114Z"}, {"entity": "publication", "iuid": "7f57776f36ed41deb09c507dede3348d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7f57776f36ed41deb09c507dede3348d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7f57776f36ed41deb09c507dede3348d"}}, "title": "Is There an Effect of Fetal Mesenchymal Stem Cells in the Mother-Fetus Dyad in COVID-19 Pregnancies and Vertical Transmission?", "authors": [{"family": "Samara", "given": "Athina", "initials": "A"}, {"family": "Herlenius", "given": "Eric", "initials": "E"}], "type": "journal article", "published": "2021-02-11", "journal": {"title": "Front Physiol", "issn": "1664-042X", "issn-l": null, "volume": "11", "issue": null, "pages": "624625"}, "abstract": "Because of the polysystemic nature of coronavirus disease 2019 (COVID-19), during the present pandemic, there have been serious concerns regarding pregnancy, vertical transmission, and intrapartum risk. The majority of pregnant patients with COVID-19 infection present with mild or asymptomatic course of the disease. Some cases were hospitalized, and few needed intensive care unit admission, or mechanical ventilation. There have also been scarce case reports where neonates required mechanical ventilation post COVID-19 pregnancies. Without approved therapies other than dexamethasone, advanced mesenchymal cell therapy is one immunomodulatory therapeutic approach that is currently explored and might hold great promise. We suggest that the circulating fetal stem cells might have an immune-protective effect to mothers and contribute to the often mild and even asymptomatic post-COVID-19 pregnancies. Thus, COVID-19 pregnancies come forth as a paradigm to be further and more comprehensively approached, to understand both the mechanism and action of circulating stem cells in immunoprotection and hypoxia in microcirculation.", "doi": "10.3389/fphys.2020.624625", "pmid": "33679426", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7928412"}], "notes": [], "created": "2021-03-09T15:33:16.053Z", "modified": "2021-06-18T12:01:22.813Z"}, {"entity": "publication", "iuid": "4b706f8c6b6a4c2baefaf1e4c62560ed", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4b706f8c6b6a4c2baefaf1e4c62560ed.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4b706f8c6b6a4c2baefaf1e4c62560ed"}}, "title": "Dehumanization During the COVID-19 Pandemic", "authors": [{"family": "Markowitz", "given": "David M", "initials": "DM"}, {"family": "Shoots-Reinhard", "given": "Brittany", "initials": "B"}, {"family": "Peters", "given": "Ellen", "initials": "E"}, {"family": "Silverstein", "given": "Michael C", "initials": "MC"}, {"family": "Goodwin", "given": "Raleigh", "initials": "R"}, {"family": "Bj\u00e4lkebring", "given": "P\u00e4r", "initials": "P"}], "type": "journal-article", "published": "2021-02-11", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "12", "issue": null, "pages": null, "issn-l": "1664-1078"}, "abstract": null, "doi": "10.3389/fpsyg.2021.634543", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-03-02T06:56:54.710Z", "modified": "2021-03-02T06:56:54.720Z"}, {"entity": "publication", "iuid": "4bd12053e8924d3fb6fa414fa0c63638", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4bd12053e8924d3fb6fa414fa0c63638.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4bd12053e8924d3fb6fa414fa0c63638"}}, "title": "Problematic internet-related behaviors mediate the associations between levels of internet engagement and distress among schoolchildren during COVID-19 lockdown: A longitudinal structural equation modeling study.", "authors": [{"family": "Chen", "given": "I-Hua", "initials": "I"}, {"family": "Chen", "given": "Chao-Ying", "initials": "C"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Li", "given": "Xu-Dong", "initials": "X"}, {"family": "Tsang", "given": "Hector W H", "initials": "HWH"}], "type": "journal article", "published": "2021-02-10", "journal": {"title": "J Behav Addict", "issn": "2063-5303", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Due to the rapid spread of the novel coronavirus disease 2019 (COVID-19), policies based on the nature of \"spatial distancing\" have been implemented and have resulted in school suspensions and online learning among schoolchildren. In order to examine the impact of such policies on schoolchildren, the aims of the present study were to (i) assess changes in the level of engagement in three internet-related activities (smartphone use, social media use, and gaming) before and during the COVID-19 outbreak, including prolonged and problematic engagement in these activities; (ii) investigate the differences of psychological distress before and after COVID-19 outbreak; and (iii) to use structural equation modeling to investigate the mediating roles of problematic internet-related behaviors in the causal relationships of psychological distress and time spent on internet-related activities.\r\n\r\nSelf-report measures were used to assess internet-related activities and psychological distress. Time spent on internet-related activities, problematic use of internet-related activities, and psychological distress were collected from primary school students (N = 535; 265 boys; M age = 10.32 years [SD = 0.84]). The data were first collected before the COVID-19 outbreak (i.e., early November 2019) and then collected again during the school suspension due to COVID-19 outbreak (i.e., end of March 2020) for comparisons of changes.\r\n\r\nSchoolchildren spent significantly more time on the smartphone (increased 1.02 h daily; P < 0.001) and social media (increased 0.73 h daily; P < 0.001) but not gaming (increased 0.14 h daily; P = 0.07) during the school suspension compared to the baseline. Schoolchildren who increased by 15 or 30 min daily on internet-related activities showed an increased level of psychological distress. The association between problematic use of social media and psychological distress was stronger during the school suspension (\u03b2 = 0.584) than at the baseline (\u03b2 = 0.451; P < 0.001).\r\n\r\nIncreased problematic use of internet-related activities among schoolchildren was associated with greater psychological distress. Parents should therefore monitor internet-related activities and psychological distress of their children to support their mental health.", "doi": "10.1556/2006.2021.00006", "pmid": "33570506", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-15T17:33:28.219Z", "modified": "2021-06-18T12:07:46.281Z"}, {"entity": "publication", "iuid": "2b523eff6797470a962feeedf8b57d7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b523eff6797470a962feeedf8b57d7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b523eff6797470a962feeedf8b57d7e"}}, "title": "Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19.", "authors": [{"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Czarlewski", "given": "Wienczyslawa", "initials": "W"}, {"family": "Zuberbier", "given": "Torsten", "initials": "T"}, {"family": "Mullol", "given": "Joaquim", "initials": "J"}, {"family": "Blain", "given": "Hubert", "initials": "H"}, {"family": "Cristol", "given": "Jean-Paul", "initials": "JP"}, {"family": "De La Torre", "given": "Rafael", "initials": "R"}, {"family": "Pizarro Lozano", "given": "Nieves", "initials": "N"}, {"family": "Le Moing", "given": "Vincent", "initials": "V"}, {"family": "Bedbrook", "given": "Anna", "initials": "A"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Akdis", "given": "Cezmi A", "initials": "CA"}, {"family": "Canonica", "given": "G Walter", "initials": "GW"}, {"family": "Cruz", "given": "Alvaro A", "initials": "AA"}, {"family": "Fiocchi", "given": "Alessandro", "initials": "A"}, {"family": "Fonseca", "given": "Joao A", "initials": "JA"}, {"family": "Fonseca", "given": "Susana", "initials": "S"}, {"family": "Gemicio\u011flu", "given": "Bilun", "initials": "B"}, {"family": "Haahtela", "given": "Tari", "initials": "T"}, {"family": "Iaccarino", "given": "Guido", "initials": "G"}, {"family": "Ivancevich", "given": "Juan Carlos", "initials": "JC"}, {"family": "Jutel", "given": "Marek", "initials": "M"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Kraxner", "given": "Helga", "initials": "H"}, {"family": "Kuna", "given": "Piotr", "initials": "P"}, {"family": "Larenas-Linnemann", "given": "D\u00e9sir\u00e9e E", "initials": "DE"}, {"family": "Martineau", "given": "Adrian", "initials": "A"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Okamoto", "given": "Yoshitaka", "initials": "Y"}, {"family": "Papadopoulos", "given": "Nikolaos G", "initials": "NG"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Regateiro", "given": "Frederico S", "initials": "FS"}, {"family": "Reynes", "given": "Jacques", "initials": "J"}, {"family": "Rolland", "given": "Yves", "initials": "Y"}, {"family": "Rouadi", "given": "Philip W", "initials": "PW"}, {"family": "Samolinski", "given": "Boleslaw", "initials": "B"}, {"family": "Sheikh", "given": "Aziz", "initials": "A"}, {"family": "Toppila-Salmi", "given": "Sanna", "initials": "S"}, {"family": "Valiulis", "given": "Arunas", "initials": "A"}, {"family": "Choi", "given": "Hak-Jong", "initials": "HJ"}, {"family": "Kim", "given": "Hyun Ju", "initials": "HJ"}, {"family": "Anto", "given": "Josep M", "initials": "JM"}], "type": "journal article", "published": "2021-02-10", "journal": {"title": "Int Arch Allergy Immunol", "issn": "1018-2438", "volume": null, "issue": null, "pages": "1-15", "issn-l": null}, "abstract": "In this article, we propose that differences in COVID-19 morbidity may be associated with transient receptor potential ankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 (TRPV1) activation as well as desensitization. TRPA1 and TRPV1 induce inflammation and play a key role in the physiology of almost all organs. They may augment sensory or vagal nerve discharges to evoke pain and several symptoms of COVID-19, including cough, nasal obstruction, vomiting, diarrhea, and, at least partly, sudden and severe loss of smell and taste. TRPA1 can be activated by reactive oxygen species and may therefore be up-regulated in COVID-19. TRPA1 and TRPV1 channels can be activated by pungent compounds including many nuclear factor (erythroid-derived 2) (Nrf2)-interacting foods leading to channel desensitization. Interactions between Nrf2-associated nutrients and TRPA1/TRPV1 may be partly responsible for the severity of some of the COVID-19 symptoms. The regulation by Nrf2 of TRPA1/TRPV1 is still unclear, but suggested from very limited clinical evidence. In COVID-19, it is proposed that rapid desensitization of TRAP1/TRPV1 by some ingredients in foods could reduce symptom severity and provide new therapeutic strategies.", "doi": "10.1159/000514204", "pmid": "33567446", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "000514204"}], "notes": [], "created": "2021-02-11T15:22:39.327Z", "modified": "2021-02-11T15:22:39.344Z"}, {"entity": "publication", "iuid": "d0fae14071314e24ad54e8a7ccb1440a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d0fae14071314e24ad54e8a7ccb1440a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d0fae14071314e24ad54e8a7ccb1440a"}}, "title": "Community health worker knowledge, attitudes and practices towards COVID-19: Learnings from an online cross-sectional survey using a digital health platform, UpSCALE, in Mozambique.", "authors": [{"family": "Feldman", "given": "Mitra", "initials": "M"}, {"family": "Lacey Krylova", "given": "Vera", "initials": "V"}, {"family": "Farrow", "given": "Poppy", "initials": "P"}, {"family": "Donovan", "given": "Laura", "initials": "L"}, {"family": "Zandamela", "given": "Edson", "initials": "E"}, {"family": "Rebelo", "given": "Joaquim", "initials": "J"}, {"family": "Rodrigues", "given": "Maria", "initials": "M"}, {"family": "Bulo", "given": "Antonio", "initials": "A"}, {"family": "Ferraz", "given": "Carlos", "initials": "C"}, {"family": "Rodrigues", "given": "Humberto", "initials": "H"}, {"family": "Roca-Feltrer", "given": "Arantxa", "initials": "A"}, {"family": "Baker", "given": "Kevin", "initials": "K"}], "type": "journal article", "published": "2021-02-10", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "2", "pages": "e0244924"}, "abstract": "Healthcare workers (HCWs) are at the frontline of the Coronavirus Disease 2019 (COVID-19) pandemic response, yet there is a paucity of literature on their knowledge, attitudes and practices (KAP) in relation to the pandemic. Community Health Workers (CHWs) in Mozambique are known locally as agentes polivalentes elementares (APEs). While technical guidance surrounding COVID-19 is available to support APEs, communicating this information has been challenging due to restrictions on travel, face-to-face group meetings and training, imposed from May to August 2020. A digital health platform, upSCALE, that already supports 1,213 APEs and 299 supervisors across three provinces, is being used to support APEs on effective COVID-19 management by delivering COVID-19 sensitive SMS messages, training modules and a COVID-19 KAP survey. The KAP survey, conducted from June 2020 to August 2020, consisted of 10 questions. Of 1,065 active upSCALE APEs, 28% completed the survey. Results indicate that only a small proportion of APEs listed the correct COVID-19 symptoms, transmission routes and appropriate prevention measures (n = (25%), n = (16%) and n = (39%), respectively) specifically included in national health education materials. Misconceptions were mainly related to transmission routes, high risk individuals and asymptomatic patients. 84% said they followed all government prevention guidelines. The results from the KAP survey were used to support the rapid development and deployment of targeted COVID-19 awareness and education materials for the APEs. A follow-up KAP survey is planned for November 2020. Adapting the existing upSCALE platform enabled a better understanding, in real time, of the KAP of APEs around COVID-19 management. Subsequently, supporting delivery of tailored messages and education, vital for ensuring a successful COVID-19 response.", "doi": "10.1371/journal.pone.0244924", "pmid": "33566850", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-32538"}, {"db": "URL", "key": "https://reshare.ukdataservice.ac.uk/854605/", "description": "The Covid-19 pandemic: knowledge, attitudes and practice among healthcare workers in Mozambique, Survey 1, 2020"}], "notes": [], "created": "2021-02-11T15:23:36.305Z", "modified": "2021-06-18T12:05:11.207Z"}, {"entity": "publication", "iuid": "badb217a9cb84081b47447b503898d2f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/badb217a9cb84081b47447b503898d2f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/badb217a9cb84081b47447b503898d2f"}}, "title": "Anticoagulation therapy in non-valvular atrial fibrillation in the COVID-19 era: is it time to reconsider our therapeutic strategy?", "authors": [{"family": "Papakonstantinou", "given": "Panteleimon E", "initials": "PE"}, {"family": "Borovac", "given": "Josip A", "initials": "JA"}, {"family": "G\u0105secka", "given": "Aleksandra", "initials": "A"}, {"family": "Bongiovanni", "given": "Dario", "initials": "D"}, {"family": "Ehrlinder", "given": "Hanne", "initials": "H"}, {"family": "Giustozzi", "given": "Michela", "initials": "M"}, {"family": "Parker", "given": "William A E", "initials": "WAE"}, {"family": "Guerreiro", "given": "Rui Azevedo", "initials": "RA"}], "type": "journal article", "published": "2021-02-10", "journal": {"title": "Eur J Prev Cardiol", "issn": "2047-4881", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1093/eurjpc/zwab021", "pmid": "33564838", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "6132124"}, {"db": "pmc", "key": "PMC7928961"}], "notes": [], "created": "2021-02-10T18:57:47.004Z", "modified": "2021-07-14T07:51:54.412Z"}, {"entity": "publication", "iuid": "f04b983482764324aa721d7822f04bc1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f04b983482764324aa721d7822f04bc1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f04b983482764324aa721d7822f04bc1"}}, "title": "A Case Series on Critically Ill Pregnant or Newly Delivered Patients with Covid-19, Treated at Karolinska University Hospital, Stockholm", "authors": [{"family": "Polcer", "given": "Rasha El ahmad", "initials": "REa"}, {"family": "Jones", "given": "Elin", "initials": "E"}, {"family": "Pettersson", "given": "Karin", "initials": "K"}], "type": "journal-article", "published": "2021-02-10", "journal": {"title": "Case Reports in Obstetrics and Gynecology", "issn": "2090-6692", "issn-l": null, "volume": "2021", "issue": null, "pages": "1-7"}, "abstract": "In this retrospective report, we present five cases of critically ill pregnant or newly delivered women positive for Covid-19 admitted to our obstetrical departments at Karolinska University Hospital. They compose 6% of eighty-three pregnant women that tested positive for SARS-CoV-2 during the period March 25 to May 4, 2020. Three patients were at the time of admission in gestational week between 21 + 4 and 22 + 5 and treated during their antenatal period; meanwhile, the other two were admitted within 1 week postpartum. All of them were in need of intensive care: one was treated with high flow oxygen therapy, the other four with invasive mechanical ventilation (three with endotracheal intubation and one with extracorporeal membrane oxygenation). Age above thirty, overweight, and gestational diabetes are notable factors in the cases presented. At the time of admission, they all presented with symptoms such as fever, cough, and dyspnea. Chest imaging with computer tomography scan was performed in each case and demonstrated multifocal pneumonic infiltrates in all of them, but no pulmonary embolism was confirmed in any. Neither did the echocardiogram indicate any cardiomyopathy. Four of the patients have been discharged from the hospital, with an average of 20 hospital days. One antenatal pregnant woman needed prolonged ECMO therapy; in gestational week 27 + 3, she went into cardiac arrest, resulting in an urgent C-section on maternal indication. At the time of writing, she is still hospitalized. In coherence with other published reports, our cases indicate that critically ill pregnant women infected by SARS-Cov-2 may develop severe respiratory distress syndrome requiring prolonged intensive care. The material is limited for conclusions to be made; more detailed information on symptoms, treatment, and outcomes for pregnant and postpartum women managed in intensive care is therefore needed.", "doi": "10.1155/2021/8868822", "pmid": "33628548", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-02-25T12:31:56.276Z", "modified": "2021-06-18T11:42:21.196Z"}, {"entity": "publication", "iuid": "77f938e81f1d4b39b6265fbea9bfe0b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/77f938e81f1d4b39b6265fbea9bfe0b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/77f938e81f1d4b39b6265fbea9bfe0b2"}}, "title": "\"People play it down and tell me it can't kill people, but I know people are dying each day\". Children's health literacy relating to a global pandemic (COVID-19); an international cross sectional study.", "authors": [{"family": "Bray", "given": "Lucy", "initials": "L"}, {"family": "Carter", "given": "Bernie", "initials": "B"}, {"family": "Blake", "given": "Lucy", "initials": "L"}, {"family": "Saron", "given": "Holly", "initials": "H"}, {"family": "Kirton", "given": "Jennifer A", "initials": "JA"}, {"family": "Robichaud", "given": "Fanny", "initials": "F"}, {"family": "Avila", "given": "Marla", "initials": "M"}, {"family": "Ford", "given": "Karen", "initials": "K"}, {"family": "Nafria", "given": "Begonya", "initials": "B"}, {"family": "Forsner", "given": "Maria", "initials": "M"}, {"family": "Nilsson", "given": "Stefan", "initials": "S"}, {"family": "Chelkowski", "given": "Andrea", "initials": "A"}, {"family": "Middleton", "given": "Andrea", "initials": "A"}, {"family": "Rullander", "given": "Anna-Clara", "initials": "A"}, {"family": "Mattsson", "given": "Janet", "initials": "J"}, {"family": "Protheroe", "given": "Joanne", "initials": "J"}], "type": "journal article", "published": "2021-02-10", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "16", "issue": "2", "pages": "e0246405"}, "abstract": "The aim of this study was to examine aspects of children's health literacy; the information sources they were accessing, their information preferences, their perceived understanding of and their reported information needs in relation to COVID-19. An online survey for children aged 7-12 years of age and parent/caregivers from the UK, Sweden, Brazil, Spain, Canada and Australia was conducted between 6th of April and the 1st of June 2020. The surveys included demographic questions and both closed and open questions focussing on access to and understanding of COVID-19 information. Descriptive statistics and qualitative content analysis procedures were conducted. The findings show that parents are the main source of information for children during the pandemic in most countries (89%, n = 347), except in Sweden where school was the main source of information. However, in many cases parents chose to shield, filter or adapt their child's access to information about COVID-19, especially in relation to the death rates within each country. Despite this, children in this study reported knowing that COVID-19 was deadly and spreads quickly. This paper argues for a community rather than individual approach to addressing children's health literacy needs during a pandemic.", "doi": "10.1371/journal.pone.0246405", "pmid": "33566813", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-19761"}], "notes": [], "created": "2021-02-11T15:29:29.582Z", "modified": "2021-06-18T12:06:38.023Z"}, {"entity": "publication", "iuid": "7278e8eb255248eb836f6d82888ae39c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7278e8eb255248eb836f6d82888ae39c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7278e8eb255248eb836f6d82888ae39c"}}, "title": "The development of preprints during the COVID-19 pandemic.", "authors": [{"family": "\u00c4lg\u00e5", "given": "Andreas", "initials": "A"}, {"family": "Eriksson", "given": "Oskar", "initials": "O"}, {"family": "Nordberg", "given": "Martin", "initials": "M"}], "type": "editorial", "published": "2021-02-09", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1111/joim.13240", "pmid": "33560546", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-10T18:59:52.815Z", "modified": "2021-02-10T18:59:52.826Z"}, {"entity": "publication", "iuid": "536b0c5204ee49c280d9f4d8249a56a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/536b0c5204ee49c280d9f4d8249a56a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/536b0c5204ee49c280d9f4d8249a56a2"}}, "title": "Sustained prothrombotic changes in COVID-19 patients 4 months after hospital discharge.", "authors": [{"family": "von Meijenfeldt", "given": "Fien A", "initials": "FA"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Adelmeijer", "given": "Jelle", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Thalin", "given": "Charlotte", "initials": "C"}, {"family": "Lisman", "given": "Ton", "initials": "T"}], "type": "journal article", "published": "2021-02-09", "journal": {"title": "Blood Adv", "issn": "2473-9537", "issn-l": null, "volume": "5", "issue": "3", "pages": "756-759"}, "abstract": null, "doi": "10.1182/bloodadvances.2020003968", "pmid": "33560386", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "475081"}], "notes": [], "created": "2021-02-10T18:46:05.850Z", "modified": "2021-06-11T14:26:07.518Z"}, {"entity": "publication", "iuid": "2b9f338fa3e240a480a9162feedee0b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b9f338fa3e240a480a9162feedee0b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b9f338fa3e240a480a9162feedee0b9"}}, "title": "Handwashing with soap: A concern for overuse of water amidst the COVID-19 pandemic in Bangladesh.", "authors": [{"family": "Sayeed", "given": "Abu", "initials": "A"}, {"family": "Rahman", "given": "Md Hafizur", "initials": "MH"}, {"family": "Bundschuh", "given": "Jochen", "initials": "J"}, {"family": "Herath", "given": "Indika", "initials": "I"}, {"family": "Ahmed", "given": "Fahad", "initials": "F"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Tariq", "given": "Mohammad Raihan", "initials": "MR"}, {"family": "Rahman", "given": "Faujhia", "initials": "F"}, {"family": "Tarikul Islam Joy", "given": "Md", "initials": "M"}, {"family": "Tazrian Abid", "given": "Mohammad", "initials": "M"}, {"family": "Saha", "given": "Nondo", "initials": "N"}, {"family": "Hasan", "given": "M Tasdik", "initials": "MT"}], "type": "journal article", "published": "2021-02-09", "journal": {"title": "Groundw Sustain Dev", "issn": "2352-801X", "volume": "13", "issue": null, "pages": "100561", "issn-l": null}, "abstract": "Handwashing is one of the vital public health measures. It helps to prevent the spread of the COVID-19 pandemic. However, water overuse during hand scrubbing with soap keeping the tap on may put enormous pressure on the already overstretched groundwater resources and households' economic well-being. Therefore, this study aimed to determine the overuse of water while scrubbing hands with soap for handwashing when the tap is on amid the COVID-19 pandemic in Bangladesh. Sociodemographic data were collected using a web-based survey tool among 1980 participants and an experiment was conducted among 126 participants to estimate the overuse of water during hand scrubbing while the tap is on. A total of 80% of the participants washed their hands regularly after returning home from outside. About 57.27% of participants did not turn off their tap throughout the handwashing process. A single participant, who kept his tap on throughout the handwashing process, overused approximately 1.7L of water per handwash and 14.9L of water per day. Hand scrubbing with soap keeping the tap on, raised the overuse of water 13-fold during this pandemic compared to the non-pandemic situation which cost an extra 224.95 BDT (2.65$) per day for 1980 participants. Minimize the speed of tap, using automatic taps, and using taps operated by legs might be an effective solution to reduce the water overuse. Furthermore, behavioral change interventions are needed to aware people turn off the tap during hand scrubbing with soap.", "doi": "10.1016/j.gsd.2021.100561", "pmid": "33585670", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2352-801X(21)00017-5"}, {"db": "pmc", "key": "PMC7871103"}], "notes": [], "created": "2021-02-17T14:50:24.246Z", "modified": "2021-03-22T11:42:49.287Z"}, {"entity": "publication", "iuid": "e562fc74663e4915acbb53b5738d65a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e562fc74663e4915acbb53b5738d65a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e562fc74663e4915acbb53b5738d65a4"}}, "title": "First detection of SARS-CoV-2 genetic material in the vicinity of COVID-19 isolation Centre in Bangladesh: Variation along the sewer network.", "authors": [{"family": "Ahmed", "given": "Firoz", "initials": "F"}, {"family": "Islam", "given": "Md Aminul", "initials": "MA"}, {"family": "Kumar", "given": "Manish", "initials": "M"}, {"family": "Hossain", "given": "Maqsud", "initials": "M"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Islam", "given": "Md Tahmidul", "initials": "MT"}, {"family": "Hossen", "given": "Foysal", "initials": "F"}, {"family": "Hossain", "given": "Md Shahadat", "initials": "MS"}, {"family": "Islam", "given": "Md Sydul", "initials": "MS"}, {"family": "Uddin", "given": "Md Main", "initials": "MM"}, {"family": "Islam", "given": "Md Nur", "initials": "MN"}, {"family": "Bahadur", "given": "Newaz Mohammed", "initials": "NM"}, {"family": "Didar-Ul-Alam", "given": "Md", "initials": "M"}, {"family": "Reza", "given": "Hasan Mahmud", "initials": "HM"}, {"family": "Jakariya", "given": "Md", "initials": "M"}], "type": "journal article", "published": "2021-02-09", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "volume": "776", "issue": null, "pages": "145724", "issn-l": "0048-9697"}, "abstract": "We made the first and successful attempt to detect SARS-CoV-2 genetic material in the vicinity wastewaters of an isolation centre i.e. Shaheed Bhulu Stadium, situated at Noakhali, Southeastern Bangladesh. Owing to the fact that isolation centre, in general, always contained a constant number of 200 COVID-19 patients, the prime objective of the study was to check if several drains carrying RNA of coronavirus are actually getting diluted or accumulated along with the sewage network. Our finding suggested that while the temporal variation of the genetic load decreased in small drains over the span of 50 days, the main sewer exhibited accumulation of SARS-CoV-2 RNA. Other interesting finding displays that probably distance of sampling location in meters is not likely to have a significant impact on the detected gene concentration, although the quantity of the RNA extracted in the downstream of the drain was higher. These findings are of immense value from the perspective of wastewater surveillance of COVID-19, as they largely imply that we do not need to monitor every wastewater system, and probably major drains monitoring may illustrate the city health. Perhaps, we are reporting the accumulation of SARS-CoV-2 genetic material along with the sewer network i.e. from primary to tertiary drains. The study sought further data collection in this line to simulate conditions prevailed in most of the developing countries and to shed further light on decay/accumulation processes of the genetic load of the SARS-COV-2.", "doi": "10.1016/j.scitotenv.2021.145724", "pmid": "33652314", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(21)00791-9"}], "notes": [], "created": "2021-03-03T17:01:46.916Z", "modified": "2021-03-03T17:01:46.926Z"}, {"entity": "publication", "iuid": "b9bc34b1d45246a19d2d3aff1df7c606", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9bc34b1d45246a19d2d3aff1df7c606.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9bc34b1d45246a19d2d3aff1df7c606"}}, "title": "COVID-19 vaccines and kidney disease.", "authors": [{"family": "Windpessl", "given": "Martin", "initials": "M"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Anders", "given": "Hans-Joachim", "initials": "HJ"}, {"family": "Kramer", "given": "Holly", "initials": "H"}, {"family": "Waldman", "given": "Meryl", "initials": "M"}, {"family": "Renia", "given": "Laurent", "initials": "L"}, {"family": "Ng", "given": "Lisa F P", "initials": "LFP"}, {"family": "Xing", "given": "Zhou", "initials": "Z"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2021-02-08", "journal": {"title": "Nat Rev Nephrol", "issn": "1759-507X", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1038/s41581-021-00406-6", "pmid": "33558753", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41581-021-00406-6"}], "notes": [], "created": "2021-02-10T18:47:05.964Z", "modified": "2021-02-10T18:47:05.975Z"}, {"entity": "publication", "iuid": "57df1c32e6104e6b9634fabdc4d27b9b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/57df1c32e6104e6b9634fabdc4d27b9b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/57df1c32e6104e6b9634fabdc4d27b9b"}}, "title": "Studying Gambling Behaviors and Responsible Gambling Tools in a Simulated Online Casino Integrated With Amazon Mechanical Turk: Development and Initial Validation of Survey Data and Platform Mechanics of the Frescati Online Research Casino", "authors": [{"family": "Lindner", "given": "Philip", "initials": "P"}, {"family": "Ramner\u00f6", "given": "Jonas", "initials": "J"}, {"family": "Ivanova", "given": "Ekaterina", "initials": "E"}, {"family": "Carlbring", "given": "Per", "initials": "P"}], "type": "journal-article", "published": "2021-02-05", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "issn-l": "1664-0640", "volume": "11", "issue": null, "pages": null}, "abstract": null, "doi": "10.3389/fpsyt.2020.571954", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-22T14:07:06.763Z", "modified": "2021-02-26T08:46:59.959Z"}, {"entity": "publication", "iuid": "cfe8ca6f92bd43ca9beba7c1fd0ed82b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfe8ca6f92bd43ca9beba7c1fd0ed82b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfe8ca6f92bd43ca9beba7c1fd0ed82b"}}, "title": "Family Transmission of COVID-19 Including a Child with MIS-C and Acute Pancreatitis.", "authors": [{"family": "Abbas", "given": "Maher", "initials": "M"}, {"family": "T\u00f6rnhage", "given": "Carl-Johan", "initials": "C"}], "type": "case reports", "published": "2021-02-05", "journal": {"title": "Int Med Case Rep J", "issn": "1179-142X", "issn-l": null, "volume": "14", "issue": null, "pages": "55-65"}, "abstract": "Spread of the novel coronavirus SARS-CoV-2, since at least December 2019, has caused a pandemic. SARS-CoV-2 causes the disease COVID-19, which can affect several human organs. Abdominal pain is one of the known symptoms, but little is known about acute pancreatitis as a complication. As well, knowledge about viral transmission in families is limited. This case report describes MIS-C and acalculous acute pancreatitis in a child who was a member of a family in which four of five members had COVID-19.\r\n\r\nA previously healthy family was infected by SARS-CoV-2 from an unknown source. The 13-year-old daughter was infected by SARS-CoV-2 and symptomatic during two periods, with an asymptomatic interval in-between. During the first period, she had transient and mild upper respiratory symptoms which was followed four weeks later by a secondary severe illness. At that point, there was inflammation in multiple organs and signs of Multisystem Inflammatory Syndrome in Children (MIS-C) and a Kawasaki-like disease with skin rash, scalded skin in hands and conjunctivitis. Myocarditis, bronchopneumonia, pancreatitis, and hepatopathy without encephalopathy were noted. She required assisted ventilation for 5 days. There were laboratory signs of disseminated intravascular coagulopathy. The multisystem inflammation was treated with intravenous immunoglobulin (IVIG) once a day for four days and immunotherapy (high dose methylprednisolone (IV) once a day, for 12 days, then tapered over 4 weeks, anakinra (IV) four times daily for 12 days), low molecular weight heparin for 22 days and salicylates for 6 weeks leading to full restoration of health. The two brothers and mother in the family had mild to moderate COVID-19 infections. The father was not affected despite close contact with his children. The household transmission and clinical course and outcome are described. No further known COVID-19 infection occurred in the neighborhood during or immediately after the family cluster was discovered.\r\n\r\nPenetrance and severity of COVID-19 can vary in family clusters. One adolescent showed a two-phase course with severe infection. This case report highlights MIS-C and acute pancreatitis as a complication associated with COVID-19 in children.", "doi": "10.2147/IMCRJ.S284480", "pmid": "33574714", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "284480"}, {"db": "pmc", "key": "PMC7872935"}], "notes": [], "created": "2021-02-15T12:55:45.375Z", "modified": "2021-06-18T11:40:22.589Z"}, {"entity": "publication", "iuid": "b4d9a71a5e6d4e88930986beffc8b7d8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b4d9a71a5e6d4e88930986beffc8b7d8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b4d9a71a5e6d4e88930986beffc8b7d8"}}, "title": "Efficacy and tolerability of bevacizumab in patients with severe Covid-19.", "authors": [{"family": "Pang", "given": "Jiaojiao", "initials": "J", "orcid": "0000-0003-0072-3703", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb34db1aeb5f4f2391db995b579ea6ea.json"}}, {"family": "Xu", "given": "Feng", "initials": "F", "orcid": "0000-0002-4670-3727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/498adee7663c41338b60b0b778220c74.json"}}, {"family": "Aondio", "given": "Gianmarco", "initials": "G"}, {"family": "Li", "given": "Yu", "initials": "Y", "orcid": "0000-0003-4798-1638", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4f22daad666482fa488f4ce3e61d529.json"}}, {"family": "Fumagalli", "given": "Alberto", "initials": "A", "orcid": "0000-0002-7126-2337", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d45660687d943c692306180fa66ab53.json"}}, {"family": "Lu", "given": "Ming", "initials": "M", "orcid": "0000-0002-8685-6322", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fce9ebd8f3c04405b9f596909fd01d16.json"}}, {"family": "Valmadre", "given": "Giuseppe", "initials": "G"}, {"family": "Wei", "given": "Jie", "initials": "J"}, {"family": "Bian", "given": "Yuan", "initials": "Y", "orcid": "0000-0001-8559-2575", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/756cab44ecb54bb9a627776894d99981.json"}}, {"family": "Canesi", "given": "Margherita", "initials": "M"}, {"family": "Damiani", "given": "Giovanni", "initials": "G", "orcid": "0000-0003-1736-9480", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00a2feef9a8a4fd28bd5edb74ab4935d.json"}}, {"family": "Zhang", "given": "Yuan", "initials": "Y", "orcid": "0000-0003-1052-2286", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab7225c5de0247e8b675a1099dae61b2.json"}}, {"family": "Yu", "given": "Dexin", "initials": "D", "orcid": "0000-0001-7462-3153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/febf345d28374bf49009cb2a2d0cd5b8.json"}}, {"family": "Chen", "given": "Jun", "initials": "J", "orcid": "0000-0002-4865-9977", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad80138669a240f8bd11e1502ba55539.json"}}, {"family": "Ji", "given": "Xiang", "initials": "X"}, {"family": "Sui", "given": "Wenhai", "initials": "W", "orcid": "0000-0001-6114-0443", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79e84ee2d66c4463a20ced8545e4f7c1.json"}}, {"family": "Wang", "given": "Bailu", "initials": "B", "orcid": "0000-0002-5420-9569", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceefa93c6e3e4f2fb606d20435630b3c.json"}}, {"family": "Wu", "given": "Shuo", "initials": "S", "orcid": "0000-0003-3684-4363", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/502c977738674afc94abc7866b5acb65.json"}}, {"family": "Kovacs", "given": "Attila", "initials": "A"}, {"family": "Revera", "given": "Miriam", "initials": "M"}, {"family": "Wang", "given": "Hao", "initials": "H", "orcid": "0000-0003-4493-3147", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4fdb7f4d1b04a5dae7c2ce062117149.json"}}, {"family": "Jing", "given": "Xu", "initials": "X"}, {"family": "Zhang", "given": "Ying", "initials": "Y", "orcid": "0000-0003-1052-2286", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab7225c5de0247e8b675a1099dae61b2.json"}}, {"family": "Chen", "given": "Yuguo", "initials": "Y", "orcid": "0000-0001-9501-2546", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2960cdc067cd4ee7ad01f08951fe6e15.json"}}, {"family": "Cao", "given": "Yihai", "initials": "Y", "orcid": "0000-0003-1308-0065", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e94efe139da46f3888539ccf8c6d6cf.json"}}], "type": "clinical trial", "published": "2021-02-05", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "814"}, "abstract": "On the basis of Covid-19-induced pulmonary pathological and vascular changes, we hypothesize that the anti-vascular endothelial growth factor (VEGF) drug bevacizumab might be beneficial for treating Covid-19 patients. From Feb 15 to April 5, 2020, we conducted a single-arm trial (NCT04275414) and recruited 26 patients from 2-centers (China and Italy) with severe Covid-19, with respiratory rate \u226530 times/min, oxygen saturation \u226493% with ambient air, or partial arterial oxygen pressure to fraction of inspiration O2 ratio (PaO2/FiO2) >100 mmHg and \u2264300 mmHg, and diffuse pneumonia confirmed by chest imaging. Followed up for 28 days. Among these, bevacizumab plus standard care markedly improves the PaO2/FiO2 ratios at days 1 and 7. By day 28, 24 (92%) patients show improvement in oxygen-support status, 17 (65%) patients are discharged, and none show worsen oxygen-support status nor die. Significant reduction of lesion areas/ratios are shown in chest computed tomography (CT) or X-ray within 7 days. Of 14 patients with fever, body temperature normalizes within 72 h in 13 (93%) patients. Relative to comparable controls, bevacizumab shows clinical efficacy by improving oxygenation and shortening oxygen-support duration. Our findings suggest bevacizumab plus standard care is highly beneficial for patients with severe Covid-19. Randomized controlled trial is warranted.", "doi": "10.1038/s41467-021-21085-8", "pmid": "33547300", "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC7864918"}, {"db": "pii", "key": "10.1038/s41467-021-21085-8"}, {"db": "ClinicalTrials.gov", "key": "NCT04275414"}, {"db": "figshare", "key": "10.6084/m9.figshare.13482810"}, {"db": "figshare", "key": "10.6084/m9.figshare.13482834"}], "notes": [], "created": "2021-02-05T11:00:55.502Z", "modified": "2023-06-19T14:36:24.662Z"}, {"entity": "publication", "iuid": "95af2e1173584d369a02dd581c426f45", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95af2e1173584d369a02dd581c426f45.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95af2e1173584d369a02dd581c426f45"}}, "title": "The impact of COVID-19 on oncology professionals: results of the ESMO Resilience Task Force survey collaboration.", "authors": [{"family": "Banerjee", "given": "S", "initials": "S"}, {"family": "Lim", "given": "K H J", "initials": "KHJ"}, {"family": "Murali", "given": "K", "initials": "K"}, {"family": "Kamposioras", "given": "K", "initials": "K"}, {"family": "Punie", "given": "K", "initials": "K"}, {"family": "Oing", "given": "C", "initials": "C"}, {"family": "O'Connor", "given": "M", "initials": "M"}, {"family": "Thorne", "given": "E", "initials": "E"}, {"family": "Devnani", "given": "B", "initials": "B"}, {"family": "Lambertini", "given": "M", "initials": "M"}, {"family": "Westphalen", "given": "C B", "initials": "CB"}, {"family": "Garrido", "given": "P", "initials": "P"}, {"family": "Amaral", "given": "T", "initials": "T"}, {"family": "Morgan", "given": "G", "initials": "G"}, {"family": "Haanen", "given": "J B A G", "initials": "JBAG"}, {"family": "Hardy", "given": "C", "initials": "C"}], "type": "journal article", "published": "2021-02-04", "journal": {"title": "ESMO Open", "issn": "2059-7029", "issn-l": null, "volume": "6", "issue": "2", "pages": "100058"}, "abstract": "The impact of the coronavirus disease 2019 (COVID-19) pandemic on well-being has the potential for serious negative consequences on work, home life, and patient care. The European Society for Medical Oncology (ESMO) Resilience Task Force collaboration set out to investigate well-being in oncology over time since COVID-19.\r\n\r\nTwo online anonymous surveys were conducted (survey I: April/May 2020; survey II: July/August 2020). Statistical analyses were performed to examine group differences, associations, and predictors of key outcomes: (i) well-being/distress [expanded Well-being Index (eWBI; 9 items)]; (ii) burnout (1 item from eWBI); (iii) job performance since COVID-19 (JP-CV; 2 items).\r\n\r\nResponses from survey I (1520 participants from 101 countries) indicate that COVID-19 is impacting oncology professionals; in particular, 25% of participants indicated being at risk of distress (poor well-being, eWBI \u2265 4), 38% reported feeling burnout, and 66% reported not being able to perform their job compared with the pre-COVID-19 period. Higher JP-CV was associated with better well-being and not feeling burnout (P < 0.01). Differences were seen in well-being and JP-CV between countries (P < 0.001) and were related to country COVID-19 crude mortality rate (P < 0.05). Consistent predictors of well-being, burnout, and JP-CV were psychological resilience and changes to work hours. In survey II, among 272 participants who completed both surveys, while JP-CV improved (38% versus 54%, P < 0.001), eWBI scores \u22654 and burnout rates were significantly higher compared with survey I (22% versus 31%, P = 0.01; and 35% versus 49%, P = 0.001, respectively), suggesting well-being and burnout have worsened over a 3-month period during the COVID-19 pandemic.\r\n\r\nIn the first and largest global survey series, COVID-19 is impacting well-being and job performance of oncology professionals. JP-CV has improved but risk of distress and burnout has increased over time. Urgent measures to address well-being and improve resilience are essential.", "doi": "10.1016/j.esmoop.2021.100058", "pmid": "33601295", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2059-7029(21)00013-2"}], "notes": [], "created": "2021-02-19T14:07:28.255Z", "modified": "2021-06-18T11:32:37.310Z"}, {"entity": "publication", "iuid": "9289ed9c644f4e02942703bee07dda08", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9289ed9c644f4e02942703bee07dda08.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9289ed9c644f4e02942703bee07dda08"}}, "title": "DNA-launched RNA replicon vaccines induce potent anti-SARS-CoV-2 immune responses in mice", "authors": [{"family": "Szurgot", "given": "Inga", "initials": "I"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Vidakovics", "given": "Laura Perez", "initials": "LP"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}, {"family": "Liljestr\u00f6m", "given": "Peter", "initials": "P"}], "type": "journal-article", "published": "2021-02-04", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "3125"}, "abstract": "The outbreak of the SARS-CoV-2 virus and its rapid spread into a global pandemic made the urgent development of scalable vaccines to prevent coronavirus disease (COVID-19) a global health and economic imperative. Here, we characterized and compared the immunogenicity of two alphavirus-based DNA-launched self-replicating (DREP) vaccine candidates encoding either SARS-CoV-2 spike glycoprotein (DREP-S) or a spike ectodomain trimer stabilized in prefusion conformation (DREP-S ecto). We observed that the two DREP constructs were immunogenic in mice inducing both binding and neutralizing antibodies as well as T cell responses. Interestingly, the DREP coding for the unmodified spike turned out to be more potent vaccine candidate, eliciting high titers of SARS-CoV-2 specific IgG antibodies that were able to efficiently neutralize pseudotyped virus after a single immunization. In addition, both DREP constructs were able to efficiently prime responses that could be boosted with a heterologous spike protein immunization. These data provide important novel insights into SARS-CoV-2 vaccine design using a rapid response DNA vaccine platform. Moreover, they encourage the use of mixed vaccine modalities as a strategy to combat SARS-CoV-2.", "doi": "10.1038/s41598-021-82498-5", "pmid": "33542325", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Drug Discovery": null, "Category: Vaccines": null}, "xrefs": [], "notes": [], "created": "2021-02-04T20:58:59.276Z", "modified": "2021-12-07T15:32:28.810Z"}, {"entity": "publication", "iuid": "c14184ccb8cd435ca5b458a45a37aa30", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c14184ccb8cd435ca5b458a45a37aa30.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c14184ccb8cd435ca5b458a45a37aa30"}}, "title": "The male disadvantage in life expectancy: can we close the gender gap?", "authors": [{"family": "Hossin", "given": "Muhammad Zakir", "initials": "MZ"}], "type": "journal-article", "published": "2021-02-03", "journal": {"title": "Int Health", "issn": "1876-3405", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Men are usually considered to be the stronger sex. However, when it comes to health, they are evidently weaker than their female counterparts. In almost all countries around the world, men consistently live shorter lives than women. The gender gap in longevity has once again been evident during the ongoing coronavirus disease 2019 (COVID-19) pandemic, which kills men disproportionately. Drawing on the relevant scientific literature and updated information, this article aimed to provide useful insights into the biological and social mechanisms that potentially underlie the gender gap in life expectancy.", "doi": "10.1093/inthealth/ihaa106", "pmid": "33533409", "labels": {"Type: Other": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "6127106"}], "notes": [], "created": "2021-02-04T18:12:38.304Z", "modified": "2021-06-18T11:21:35.267Z"}, {"entity": "publication", "iuid": "f9a0683bd2434fbdafbc5b3ab6408805", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f9a0683bd2434fbdafbc5b3ab6408805.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f9a0683bd2434fbdafbc5b3ab6408805"}}, "title": "Differential expression of Angiotensin-Converting Enzyme 2 in Nasal Tissue of Patients with Chronic Rhinosinusitis with Nasal Polyps", "authors": [{"family": "Fowler", "given": "Philippa C", "initials": "PC"}, {"family": "Naluai", "given": "\u00c5sa Torinsson", "initials": "\u00c5T"}, {"family": "Oscarsson", "given": "Martin", "initials": "M"}, {"family": "Torkzadeh", "given": "Sara", "initials": "S"}, {"family": "Bohman", "given": "Anton", "initials": "A"}, {"family": "Bende", "given": "Mats", "initials": "M"}, {"family": "Harandi", "given": "Ali M", "initials": "AM"}], "type": "posted-content", "published": "2021-02-03", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.02.01.21250623", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-02-11T15:43:20.813Z", "modified": "2021-06-17T08:02:05.809Z"}, {"entity": "publication", "iuid": "673c6de5246548888c52474ae57417cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/673c6de5246548888c52474ae57417cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/673c6de5246548888c52474ae57417cc"}}, "title": "COVID-19 Herd Immunity in the Absence of a Vaccine: An Irresponsible Approach.", "authors": [{"family": "Khalife", "given": "Jade", "initials": "J"}, {"family": "VanGennep", "given": "Derrick", "initials": "D"}], "type": "journal article", "published": "2021-02-03", "journal": {"title": "Epidemiol Health", "issn": "2092-7193", "volume": null, "issue": null, "pages": "e2021012", "issn-l": null}, "abstract": "With SARS-CoV-2 continuing to spread rapidly throughout the human population, the concept of 'herd immunity' has been attracting the attention of both decision makers and the general public. In the absence of a vaccine, this entails that a large proportion of the population be infected to develop immunity that would limit the severity and/or extent of subsequent outbreaks. We argue that adopting such an approach should be avoided for several reasons: There are significant uncertainties about whether achieving herd immunity is possible. If possible, achieving herd immunity would impose a large burden on society. There are gaps in protection, making it difficult to shield the vulnerable. It would defeat the purpose of avoiding harm caused by the virus. Lastly, dozens of countries are showing that containment is possible.", "doi": "10.4178/epih.e2021012", "pmid": "33541010", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "epih.e2021012"}], "notes": [], "created": "2021-02-05T11:29:57.851Z", "modified": "2021-02-05T11:29:57.876Z"}, {"entity": "publication", "iuid": "82ee9b48aa8b42e2a02f0d191c2674af", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82ee9b48aa8b42e2a02f0d191c2674af.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82ee9b48aa8b42e2a02f0d191c2674af"}}, "title": "The international Perinatal Outcomes in the Pandemic (iPOP) study: protocol.", "authors": [{"family": "Stock", "given": "Sarah J", "initials": "SJ", "orcid": "0000-0003-4308-856X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c04f8cfa9161491eb157b1bea4cc8a6a.json"}}, {"family": "Zoega", "given": "Helga", "initials": "H", "orcid": "0000-0003-0761-9028", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52887f3b5931453494a3416c0b97ce9b.json"}}, {"family": "Brockway", "given": "Meredith", "initials": "M"}, {"family": "Mulholland", "given": "Rachel H", "initials": "RH"}, {"family": "Miller", "given": "Jessica E", "initials": "JE", "orcid": "0000-0002-1806-1894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d973c66d5b5c4f779651915daa7b305c.json"}}, {"family": "Been", "given": "Jasper V", "initials": "JV", "orcid": "0000-0002-4907-6466", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/27a8e734cc6a49f6ba5f9f25dc6f4235.json"}}, {"family": "Wood", "given": "Rachael", "initials": "R", "orcid": "0000-0003-4453-623X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6cffadf504ae4f9eac53cdc2a00ffb8a.json"}}, {"family": "Abok", "given": "Ishaya I", "initials": "II"}, {"family": "Alshaikh", "given": "Belal", "initials": "B", "orcid": "0000-0002-6080-6888", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4fd691f58969420c9695cfc7645f8d31.json"}}, {"family": "Ayede", "given": "Adejumoke I", "initials": "AI"}, {"family": "Bacchini", "given": "Fabiana", "initials": "F", "orcid": "0000-0003-4343-774X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3722ddcfd11442d68ba7c8fb79abd694.json"}}, {"family": "Bhutta", "given": "Zulfiqar A", "initials": "ZA"}, {"family": "Brew", "given": "Bronwyn K", "initials": "BK"}, {"family": "Brook", "given": "Jeffrey", "initials": "J"}, {"family": "Calvert", "given": "Clara", "initials": "C"}, {"family": "Campbell-Yeo", "given": "Marsha", "initials": "M", "orcid": "0000-0001-6645-2809", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3004a18f0ace4dbb8d828698c2123337.json"}}, {"family": "Chan", "given": "Deborah", "initials": "D"}, {"family": "Chirombo", "given": "James", "initials": "J", "orcid": "0000-0003-3132-3710", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ebca6beba4e44841be3edf1f15431ca6.json"}}, {"family": "Connor", "given": "Kristin L", "initials": "KL"}, {"family": "Daly", "given": "Mandy", "initials": "M", "orcid": "0000-0001-7539-4874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/10829e2a02064b19a2472c5c82c2bf0e.json"}}, {"family": "Einarsd\u00f3ttir", "given": "Kristjana", "initials": "K", "orcid": "0000-0003-4931-7650", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b9f81f471fa43c2a372d34651f0c64e.json"}}, {"family": "Fantasia", "given": "Ilaria", "initials": "I"}, {"family": "Franklin", "given": "Meredith", "initials": "M"}, {"family": "Fraser", "given": "Abigail", "initials": "A", "orcid": "0000-0002-7741-9470", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f1caaab396a4cf1a2b2e6f9f4442684.json"}}, {"family": "H\u00e5berg", "given": "Siri Eldevik", "initials": "SE"}, {"family": "Hui", "given": "Lisa", "initials": "L"}, {"family": "Huicho", "given": "Luis", "initials": "L"}, {"family": "Magnus", "given": "Maria C", "initials": "MC", "orcid": "0000-0002-0568-3774", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3530918cfd534021a45a80628c89c580.json"}}, {"family": "Morris", "given": "Andrew D", "initials": "AD"}, {"family": "Nagy-Bonnard", "given": "Livia", "initials": "L"}, {"family": "Nassar", "given": "Natasha", "initials": "N"}, {"family": "Nyadanu", "given": "Sylvester Dodzi", "initials": "SD"}, {"family": "Iyabode Olabisi", "given": "Dedeke", "initials": "D"}, {"family": "Palmer", "given": "Kirsten R", "initials": "KR"}, {"family": "Pedersen", "given": "Lars Henning", "initials": "LH", "orcid": "0000-0001-6726-1991", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1ad7974d474490db8e59e0211b560d7.json"}}, {"family": "Pereira", "given": "Gavin", "initials": "G"}, {"family": "Racine-Poon", "given": "Amy", "initials": "A"}, {"family": "Ranger", "given": "Manon", "initials": "M", "orcid": "0000-0001-8253-0686", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73deca7ec726431085d33dc7edcf8435.json"}}, {"family": "Rihs", "given": "Tonia", "initials": "T"}, {"family": "Saner", "given": "Christoph", "initials": "C", "orcid": "0000-0003-1380-0341", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e95e43b46b343fab9da330d1ab34bed.json"}}, {"family": "Sheikh", "given": "Aziz", "initials": "A", "orcid": "0000-0001-7022-3056", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/82e1b46e1bd74c51a84294d5fe0326da.json"}}, {"family": "Swift", "given": "Emma M", "initials": "EM", "orcid": "0000-0001-9476-130X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b583b9bece114d069a239a41813e68f1.json"}}, {"family": "Tooke", "given": "Lloyd", "initials": "L"}, {"family": "Urquia", "given": "Marcelo L", "initials": "ML"}, {"family": "Whitehead", "given": "Clare", "initials": "C", "orcid": "0000-0001-8267-1630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2aaf1b678b3e44f2bc9224e29198ee05.json"}}, {"family": "Yilgwan", "given": "Christopher", "initials": "C", "orcid": "0000-0003-4741-7009", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2610d1daa034c88818778cf507e7dfe.json"}}, {"family": "Rodriguez", "given": "Natalie", "initials": "N"}, {"family": "Burgner", "given": "David", "initials": "D", "orcid": "0000-0002-8304-4302", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/300873d0d8e6457487f9d120f43ecd75.json"}}, {"family": "Azad", "given": "Meghan B", "initials": "MB", "orcid": "0000-0002-5942-4444", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/283604a1391c483f931b22e45f7a7edb.json"}}, {"family": "iPOP Study Team", "given": "", "initials": ""}], "type": "journal article", "published": "2021-02-02", "journal": {"title": "Wellcome Open Res", "issn": "2398-502X", "volume": "6", "pages": "21", "issn-l": null}, "abstract": "Preterm birth is the leading cause of infant death worldwide, but the causes of preterm birth are largely unknown. During the early COVID-19 lockdowns, dramatic reductions in preterm birth were reported; however, these trends may be offset by increases in stillbirth rates. It is important to study these trends globally as the pandemic continues, and to understand the underlying cause(s). Lockdowns have dramatically impacted maternal workload, access to healthcare, hygiene practices, and air pollution - all of which could impact perinatal outcomes and might affect pregnant women differently in different regions of the world. In the international Perinatal Outcomes in the Pandemic (iPOP) Study, we will seize the unique opportunity offered by the COVID-19 pandemic to answer urgent questions about perinatal health. In the first two study phases, we will use population-based aggregate data and standardized outcome definitions to: 1) Determine rates of preterm birth, low birth weight, and stillbirth and describe changes during lockdowns; and assess if these changes are consistent globally, or differ by region and income setting, 2) Determine if the magnitude of changes in adverse perinatal outcomes during lockdown are modified by regional differences in COVID-19 infection rates, lockdown stringency, adherence to lockdown measures, air quality, or other social and economic markers, obtained from publicly available datasets. We will undertake an interrupted time series analysis covering births from January 2015 through July 2020. The iPOP Study will involve at least 121 researchers in 37 countries, including obstetricians, neonatologists, epidemiologists, public health researchers, environmental scientists, and policymakers. We will leverage the most disruptive and widespread \"natural experiment\" of our lifetime to make rapid discoveries about preterm birth. Whether the COVID-19 pandemic is worsening or unexpectedly improving perinatal outcomes, our research will provide critical new information to shape prenatal care strategies throughout (and well beyond) the pandemic.", "doi": "10.12688/wellcomeopenres.16507.1", "pmid": "34722933", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8524299"}], "notes": [], "created": "2021-11-02T15:31:32.649Z", "modified": "2021-11-02T15:31:33.258Z"}, {"entity": "publication", "iuid": "98576a905b2949ec84bfa0e9efb649c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/98576a905b2949ec84bfa0e9efb649c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/98576a905b2949ec84bfa0e9efb649c0"}}, "title": "Give more data, awareness and control to individual citizens, and they will help COVID-19 containment.", "authors": [{"family": "Nanni", "given": "Mirco", "initials": "M"}, {"family": "Andrienko", "given": "Gennady", "initials": "G"}, {"family": "Barab\u00e1si", "given": "Albert-L\u00e1szl\u00f3", "initials": "AL"}, {"family": "Boldrini", "given": "Chiara", "initials": "C"}, {"family": "Bonchi", "given": "Francesco", "initials": "F"}, {"family": "Cattuto", "given": "Ciro", "initials": "C"}, {"family": "Chiaromonte", "given": "Francesca", "initials": "F"}, {"family": "Comand\u00e9", "given": "Giovanni", "initials": "G"}, {"family": "Conti", "given": "Marco", "initials": "M"}, {"family": "Cot\u00e9", "given": "Mark", "initials": "M"}, {"family": "Dignum", "given": "Frank", "initials": "F"}, {"family": "Dignum", "given": "Virginia", "initials": "V"}, {"family": "Domingo-Ferrer", "given": "Josep", "initials": "J"}, {"family": "Ferragina", "given": "Paolo", "initials": "P"}, {"family": "Giannotti", "given": "Fosca", "initials": "F"}, {"family": "Guidotti", "given": "Riccardo", "initials": "R"}, {"family": "Helbing", "given": "Dirk", "initials": "D"}, {"family": "Kaski", "given": "Kimmo", "initials": "K"}, {"family": "Kertesz", "given": "Janos", "initials": "J"}, {"family": "Lehmann", "given": "Sune", "initials": "S"}, {"family": "Lepri", "given": "Bruno", "initials": "B"}, {"family": "Lukowicz", "given": "Paul", "initials": "P"}, {"family": "Matwin", "given": "Stan", "initials": "S"}, {"family": "Jim\u00e9nez", "given": "David Meg\u00edas", "initials": "DM"}, {"family": "Monreale", "given": "Anna", "initials": "A"}, {"family": "Morik", "given": "Katharina", "initials": "K"}, {"family": "Oliver", "given": "Nuria", "initials": "N"}, {"family": "Passarella", "given": "Andrea", "initials": "A"}, {"family": "Passerini", "given": "Andrea", "initials": "A"}, {"family": "Pedreschi", "given": "Dino", "initials": "D"}, {"family": "Pentland", "given": "Alex", "initials": "A"}, {"family": "Pianesi", "given": "Fabio", "initials": "F"}, {"family": "Pratesi", "given": "Francesca", "initials": "F"}, {"family": "Rinzivillo", "given": "Salvatore", "initials": "S"}, {"family": "Ruggieri", "given": "Salvatore", "initials": "S"}, {"family": "Siebes", "given": "Arno", "initials": "A"}, {"family": "Torra", "given": "Vicenc", "initials": "V"}, {"family": "Trasarti", "given": "Roberto", "initials": "R"}, {"family": "Hoven", "given": "Jeroen van den", "initials": "JVD"}, {"family": "Vespignani", "given": "Alessandro", "initials": "A"}], "type": "journal article", "published": "2021-02-02", "journal": {"title": "Ethics Inf Technol", "issn": "1388-1957", "volume": null, "issue": null, "pages": "1-6", "issn-l": null}, "abstract": "The rapid dynamics of COVID-19 calls for quick and effective tracking of virus transmission chains and early detection of outbreaks, especially in the \"phase 2\" of the pandemic, when lockdown and other restriction measures are progressively withdrawn, in order to avoid or minimize contagion resurgence. For this purpose, contact-tracing apps are being proposed for large scale adoption by many countries. A centralized approach, where data sensed by the app are all sent to a nation-wide server, raises concerns about citizens' privacy and needlessly strong digital surveillance, thus alerting us to the need to minimize personal data collection and avoiding location tracking. We advocate the conceptual advantage of a decentralized approach, where both contact and location data are collected exclusively in individual citizens' \"personal data stores\", to be shared separately and selectively (e.g., with a backend system, but possibly also with other citizens), voluntarily, only when the citizen has tested positive for COVID-19, and with a privacy preserving level of granularity. This approach better protects the personal sphere of citizens and affords multiple benefits: it allows for detailed information gathering for infected people in a privacy-preserving fashion; and, in turn this enables both contact tracing, and, the early detection of outbreak hotspots on more finely-granulated geographic scale. The decentralized approach is also scalable to large populations, in that only the data of positive patients need be handled at a central level. Our recommendation is two-fold. First to extend existing decentralized architectures with a light touch, in order to manage the collection of location data locally on the device, and allow the user to share spatio-temporal aggregates-if and when they want and for specific aims-with health authorities, for instance. Second, we favour a longer-term pursuit of realizing a Personal Data Store vision, giving users the opportunity to contribute to collective good in the measure they want, enhancing self-awareness, and cultivating collective efforts for rebuilding society.", "doi": "10.1007/s10676-020-09572-w", "pmid": "33551673", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "9572"}, {"db": "pmc", "key": "PMC7851322"}], "notes": [], "created": "2021-02-10T18:48:38.200Z", "modified": "2021-02-10T18:48:38.209Z"}, {"entity": "publication", "iuid": "d1867d7cef094b43aa4ba9d4261915fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1867d7cef094b43aa4ba9d4261915fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1867d7cef094b43aa4ba9d4261915fd"}}, "title": "The local governance of COVID-19: Disease prevention and social security in rural India.", "authors": [{"family": "Dutta", "given": "Anwesha", "initials": "A"}, {"family": "Fischer", "given": "Harry W", "initials": "HW"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "World Dev", "issn": "0305-750X", "issn-l": null, "volume": "138", "issue": null, "pages": "105234"}, "abstract": "Countries around the world have undertaken a wide range of strategies to halt the spread of COVID-19 and control the economic fallout left in its wake. Rural areas of developing countries pose particular difficulties for developing and implementing effective responses owing to underdeveloped health infrastructure, uneven state capacity for infection control, and endemic poverty. This paper makes the case for the critical role of local governance in coordinating pandemic response by examining how state authorities are attempting to bridge the gap between the need for rapid, vigorous response to the pandemic and local realities in three Indian states - Rajasthan, Odisha, and Kerala. Through a combination of interviews with mid and low-level bureaucrats and a review of policy documents, we show how the urgency of COVID-19 response has galvanized new kinds of cross-sectoral and multi-scalar interaction between administrative units involved in coordinating responses, as local governments have assumed central responsibility in the implementation of disease control and social security mechanisms. Evidence from Kerala in particular suggests that the state's long term investment in democratic local government and arrangements for incorporating women within grassroots state functions (through its Kudumbashree program) has built a high degree of public trust and cooperation with state actors, while local authorities embrace an ethic of care in the implementation of state responses. These observations, from the early months of the pandemic in South Asia, can serve as a foundation for future studies of how existing institutional arrangements and their histories pattern the long-term success of disease control and livelihood support as the pandemic proceeds. Governance, we argue, will be as important to understanding the trajectory of COVID-19 impacts and recovery as biology, demography, and economy.", "doi": "10.1016/j.worlddev.2020.105234", "pmid": "33106724", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0305-750X(20)30361-2"}, {"db": "pmc", "key": "PMC7578699"}], "notes": [], "created": "2020-11-27T11:47:52.870Z", "modified": "2021-01-22T16:08:54.437Z"}, {"entity": "publication", "iuid": "2f879921db144584abafdc455753d1da", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2f879921db144584abafdc455753d1da.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2f879921db144584abafdc455753d1da"}}, "title": "Richard Horton. The COVID-19 Catastrophe. What\u2019s Gone Wrong and How to Stop it Happening Again?", "authors": [{"family": "Allebeck", "given": "Peter", "initials": "P", "orcid": "0000-0002-2778-6467", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de9f0e1c3e4d402b93e61ad1c5a771fb.json"}}], "type": "journal-article", "published": "2021-02-01", "journal": {"title": "Eur J Public Health", "issn": "1101-1262", "volume": "31", "issue": "1", "pages": "234-234", "issn-l": null}, "abstract": null, "doi": "10.1093/eurpub/ckaa216", "pmid": "33231611", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "5998562"}], "notes": [], "created": "2020-11-26T12:36:05.407Z", "modified": "2023-06-19T07:33:25.394Z"}, {"entity": "publication", "iuid": "f01c7f0716244665a5ce072be3c80321", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f01c7f0716244665a5ce072be3c80321.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f01c7f0716244665a5ce072be3c80321"}}, "title": "Pregnant under the pressure of a pandemic: a large-scale longitudinal survey before and during the COVID-19 outbreak.", "authors": [{"family": "Naurin", "given": "Elin", "initials": "E"}, {"family": "Markstedt", "given": "Elias", "initials": "E"}, {"family": "Stolle", "given": "Dietlind", "initials": "D"}, {"family": "Enstr\u00f6m", "given": "Daniel", "initials": "D"}, {"family": "Wallin", "given": "Anton", "initials": "A"}, {"family": "Andreasson", "given": "Ingrid", "initials": "I"}, {"family": "Attebo", "given": "Birgitta", "initials": "B"}, {"family": "Eriksson", "given": "Ottilia", "initials": "O"}, {"family": "Martinsson", "given": "Klara", "initials": "K"}, {"family": "Elden", "given": "Helen", "initials": "H"}, {"family": "Linden", "given": "Karolina", "initials": "K"}, {"family": "Sengpiel", "given": "Verena", "initials": "V"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": "31", "issue": "1", "pages": "7-13"}, "abstract": "One of the groups that is most vulnerable to the COVID-19 pandemic is pregnant women. They cannot choose to refrain from care; they and their children are at risk of severe complications related to the virus; and they lose comfort and support as clinics prohibit their partners and as societal restrictions demand isolation from friends and relatives. It is urgent to study how this group is faring during the pandemic and we focus here on their health-related worries.\r\n\r\nA longitudinal survey at a Swedish hospital starting 6 months before (16 September 2019) and continuing during the COVID-19 outbreak (until 25 August 2020). A total of 6941 pregnant women and partners of diverse social backgrounds were recruited. Ninety-six percent of birth-giving women in the city take early ultrasounds where recruitment took place. Sixty-two percent of the women with an appointment and fifty-one percent of all partners gave consent to participate.\r\n\r\nPregnant women experienced dramatically increased worries for their own health, as well as for their partner's and their child's health in the beginning of the pandemic. The worries remained at higher than usual levels throughout the pandemic. Similar, but less dramatic changes were seen among partners.\r\n\r\nThere is a need for heightened awareness of pregnant women's and partners' health-related worries as a consequence of the COVID-19 pandemic. Related feelings, such as anxiety, have been linked to adverse pregnancy outcome and might have long-term effects. The healthcare system needs to prepare for follow-up visits with these families.", "doi": "10.1093/eurpub/ckaa223", "pmid": "33231625", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "5999799"}, {"db": "pmc", "key": "PMC7717243"}], "notes": [], "created": "2021-02-10T18:53:52.023Z", "modified": "2021-06-18T11:48:16.756Z"}, {"entity": "publication", "iuid": "d3af55f4e3e041e991b21009616ebc1b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3af55f4e3e041e991b21009616ebc1b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3af55f4e3e041e991b21009616ebc1b"}}, "title": "Inflammatory bowel disease and risk of severe COVID-19: A nationwide population-based cohort study in Sweden.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}, {"family": "Axelrad", "given": "Jordan", "initials": "J"}, {"family": "Halfvarson", "given": "Jonas", "initials": "J"}, {"family": "Khalili", "given": "Hamed", "initials": "H"}, {"family": "Larsson", "given": "Emma", "initials": "E"}, {"family": "Lochhead", "given": "Paul", "initials": "P"}, {"family": "Roelstraete", "given": "Bjorn", "initials": "B"}, {"family": "Simon", "given": "Tracey G", "initials": "TG"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Ol\u00e9n", "given": "Ola", "initials": "O"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "United European Gastroenterol J", "issn": "2050-6414", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "There are concerns that individuals with chronic immune-mediated diseases are at increased risk of COVID-19 and related severe adverse outcome, including intensive care admission or death. We aimed to explore the absolute and relative risk of severe COVID-19 in inflammatory bowel disease (IBD).\r\n\r\nThis population-based cohort study used nationwide registers in Sweden, with 67,292 individuals with a diagnosis of IBD 1969-2017 (Crohn's disease, n = 21,599; ulcerative colitis: n = 43,622; IBD-unclassified: n = 2071) and alive on 1 February 2020. Patients with IBD were matched to up to five controls from the general population (n = 297,910). Cox regression estimated hazard ratios (HRs) for (i) hospital admission with laboratory-confirmed COVID-19 as the primary diagnosis, and (ii) severe COVID-19 (composite outcome consisting of (a) COVID-19 intensive care admission, or (b) death from COVID-19 or (c) death within 30 days of COVID-19 hospital admission), were calculated. Analyses were conditioned on age, sex, calendar period, and county and adjusted for other comorbidities.\r\n\r\nBetween 1 February and 31 July 2020, 179 (0.27%) IBD patients and 500 (0.17%) general population controls were admitted to hospital with COVID-19 (adjusted HR [aHR] = 1.43; 95% CI = 1.19-1.72). The corresponding numbers for severe COVID-19 was 65 (0.10%) and 183 (0.06%; aHR = 1.11; 95% CI = 0.81-1.52). Adjusted HRs were similar in Crohn's disease and ulcerative colitis. In a propensity score-matched model taking comorbidity into account until 2016, the increased risk for COVID-19 hospital admission remained (aHR = 1.32; 1.12-1.56), but there was no increased risk of severe COVID-19 (aHR = 1.12; 0.85-1.47).\r\n\r\nWhile individuals with IBD were more likely to be admitted to hospital for COVID-19 than the general population, the risk of severe COVID-19 was not higher.", "doi": "10.1002/ueg2.12049", "pmid": "33704918", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-03-12T07:00:21.836Z", "modified": "2021-06-18T11:48:54.131Z"}, {"entity": "publication", "iuid": "87a74bf619444236aae8b3fba8ddf289", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87a74bf619444236aae8b3fba8ddf289.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87a74bf619444236aae8b3fba8ddf289"}}, "title": "Impact of COVID-19 lockdown on NO 2, O3, PM2.5 and PM10 concentrations and assessing air quality changes in Baghdad, Iraq.", "authors": [{"family": "Hashim", "given": "Bassim Mohammed", "initials": "BM"}, {"family": "Al-Naseri", "given": "Saadi K", "initials": "SK"}, {"family": "Al-Maliki", "given": "Ali", "initials": "A"}, {"family": "Al-Ansari", "given": "Nadhir", "initials": "N"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "volume": "754", "issue": null, "pages": "141978", "issn-l": "0048-9697"}, "abstract": "Covid-19 was first reported in Iraq on February 24, 2020. Since then, to prevent its propagation, the Iraqi government declared a state of health emergency. A set of rapid and strict countermeasures have taken, including locking down cities and limiting population's mobility. In this study, concentrations of four criteria pollutants, NO 2, O3, PM2.5 and PM10 before the lockdown from January 16 to February 29, 2020, and during four periods of partial and total lockdown from March 1 to July 24, 2020, in Baghdad were analysed. Overall, 6, 8 and 15% decreases in NO2, PM2.5, and PM10 concentrations, respectively in Baghdad during the 1st partial and total lockdown from March 1 to April 21, compared to the period before the lockdown. While, there were 13% increase in O3 for same period. During the 2nd partial lockdown from June 14 to July 24, NO2 and PM2.5 decreases 20 and 2.5%, respectively. While, there were 525 and 56% increase in O3 and PM10, respectively for same period. The air quality index (AQI) improved by 13% in Baghdad during the 1st partial lockdown from March 1 to April 21, compared to its pre-lockdown. The results of NO2 tropospheric column extracted from the Sentinel-5P satellite shown the NO2 emissions reduced up to 35 to 40% across Iraq, due to lockdown measures, between January and July, 2020, especially across the major cities such as Baghdad, Basra and Erbil. The lockdown due to COVID-19 has drastic effects on social and economic aspects. However, the lockdown also has some positive effect on natural environment and air quality improvement.", "doi": "10.1016/j.scitotenv.2020.141978", "pmid": "32919315", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(20)35507-8"}, {"db": "pmc", "key": "PMC7462443"}], "notes": [], "created": "2020-12-03T15:39:23.953Z", "modified": "2021-02-26T08:46:13.355Z"}, {"entity": "publication", "iuid": "636180d45c4142939f2ff87323885946", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/636180d45c4142939f2ff87323885946.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/636180d45c4142939f2ff87323885946"}}, "title": "Funcoup 5: Functional association networks in all domains of life, supporting directed links and tissue-specificity.", "authors": [{"family": "Persson", "given": "Emma", "initials": "E"}, {"family": "Castresana-Aguirre", "given": "Miguel", "initials": "M"}, {"family": "Buzzao", "given": "Davide", "initials": "D"}, {"family": "Guala", "given": "Dimitri", "initials": "D"}, {"family": "Sonnhammer", "given": "Erik L L", "initials": "ELL"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "J Mol Biol", "issn": "1089-8638", "issn-l": null, "volume": null, "issue": null, "pages": "166835"}, "abstract": "FunCoup (https://funcoup.sbc.su.se) is one of the most comprehensive functional association networks of genes/proteins available. Functional associations are inferred by integrating different types of evidence using a redundancy-weighted na\u00efve Bayesian approach, combined with orthology transfer. FunCoup's high coverage comes from using eleven different types of evidence, and extensive transfer of information between species. Since the latest update of the database, the availability of source data has improved drastically, and user expectations on a tool for functional associations have grown. To meet these requirements, we have made a new release of FunCoup with updated source data and improved functionality. FunCoup 5 now includes 22 species from all domains of life, and the source data for evidences, gold standards, and genomes have been updated to the latest available versions. In this new release, directed regulatory links inferred from transcription factor binding can be visualized in the network viewer for the human interactome. Another new feature is the possibility to filter by genes expressed in a certain tissue in the network viewer. FunCoup 5 further includes the SARS-CoV-2 proteome, allowing users to visualize and analyze interactions between SARS-CoV-2 and human proteins in order to better understand COVID-19. This new release of FunCoup constitutes a major advance for the users, with updated sources, new species and improved functionality for analysis of the networks.", "doi": "10.1016/j.jmb.2021.166835", "pmid": "33539890", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0022-2836(21)00029-2"}], "notes": [], "created": "2021-02-05T11:28:55.073Z", "modified": "2021-08-25T14:25:20.925Z"}, {"entity": "publication", "iuid": "9b6e4f24074b4cdb818625428a92e182", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b6e4f24074b4cdb818625428a92e182.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b6e4f24074b4cdb818625428a92e182"}}, "title": "Excess mortality from COVID-19: weekly excess death rates by age and sex for Sweden and its most affected region.", "authors": [{"family": "Modig", "given": "Karin", "initials": "K"}, {"family": "Ahlbom", "given": "Anders", "initials": "A"}, {"family": "Ebeling", "given": "Marcus", "initials": "M"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": "31", "issue": "1", "pages": "17-22"}, "abstract": "Sweden has one of the highest numbers of COVID-19 deaths per inhabitant globally. However, absolute death counts can be misleading. Estimating age- and sex-specific mortality rates is necessary in order to account for the underlying population structure. Furthermore, given the difficulty of assigning causes of death, excess all-cause mortality should be estimated to assess the overall burden of the pandemic.\n\nBy estimating weekly age- and sex-specific death rates during 2020 and during the preceding 5 years, our aim is to get more accurate estimates of the excess mortality attributed to COVID-19 in Sweden, and in the most affected region Stockholm.\n\nEight weeks after Sweden's first confirmed case, the death rates at all ages above 60 were higher than for previous years. Persons above age 80 were disproportionally more affected, and men suffered greater excess mortality than women in ages up to 75 years. At older ages, the excess mortality was similar for men and women, with up to 1.5 times higher death rates for Sweden and up to 3 times higher for Stockholm. Life expectancy at age 50 declined by <1 year for Sweden and 1.5 years for Stockholm compared to 2019.\n\nThe excess mortality has been high in older ages during the pandemic, but it remains to be answered if this is because of age itself being a prognostic factor or a proxy for comorbidity. Only monitoring deaths at a national level may hide the effect of the pandemic on the regional level.", "doi": "10.1093/eurpub/ckaa218", "pmid": "33169145", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "5968985"}, {"db": "pmc", "key": "PMC7717265"}], "notes": [], "created": "2021-06-14T06:37:23.104Z", "modified": "2021-09-23T05:11:34.318Z"}, {"entity": "publication", "iuid": "302719fae97442a58c88e35043be6d72", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/302719fae97442a58c88e35043be6d72.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/302719fae97442a58c88e35043be6d72"}}, "title": "Early humoral defense: Contributing to confining Covid-19 to conducting airways?", "authors": [{"family": "Persson", "given": "Carl", "initials": "C"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "Scand J Immunol", "issn": "1365-3083", "volume": null, "issue": null, "pages": "e13024", "issn-l": null}, "abstract": "Early airway responses to Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection are of interest since they could decide whether Coronavirus disease-19 (Covid-19) will proceed to life-threatening pulmonary disease stages. Here I discuss endothelial-epithelial co-operative in vivo-responses producing first-line, humoral innate defense opportunities in human airways. The pseudostratified epithelium of human nasal and tracheobronchial airways are prime sites of exposure and infection by SARS-CoV-2. Just beneath the epithelium runs a profuse systemic microcirculation. Its postcapillary venules respond conspicuously to mucosal challenges with autacoids, allergens, and microbes, and to mere loss of epithelium. By active venular endothelial gap formation, followed by transient yielding of epithelial junctions, non-sieved plasma macromolecules move from the microcirculation to the mucosal surface. Hence, plasma-derived protein cascade systems and antimicrobial peptides would have opportunity to operate jointly on an unperturbed mucosal lining. Similarly, a plasma-derived, dynamic gel protects sites of epithelial sloughing-regeneration. Precision for this indiscriminate humoral molecular response lies in restricted location and well-regulated duration of plasma exudation. Importantly, the endothelial responsiveness of the airway microcirculation differs distinctly from the relatively non-responsive, low-pressure pulmonary microcirculation that non-specifically, almost irreversibly, leaks plasma in life-threatening Covid-19. Observations in humans of infections with rhinovirus, corona virus 229E, and influenza A and B, support a general but individually variable early occurrence of plasma exudation in human infected nasal and tracheobronchial airways. Investigations are warranted to elucidate roles of host- and drug-induced airways plasma exudation in restriction of viral infection and, specifically, whether it contributes to variable disease-responses following exposure to SARS-CoV-2.", "doi": "10.1111/sji.13024", "pmid": "33523532", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-04T18:24:22.565Z", "modified": "2021-02-04T18:24:22.587Z"}, {"entity": "publication", "iuid": "1491b4b81ef944f4b9b00b9235cbd797", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1491b4b81ef944f4b9b00b9235cbd797.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1491b4b81ef944f4b9b00b9235cbd797"}}, "title": "Decay of SARS-CoV-2 RNA along the wastewater treatment outfitted with Upflow Anaerobic Sludge Blanket (UASB) system evaluated through two sample concentration techniques.", "authors": [{"family": "Kumar", "given": "Manish", "initials": "M"}, {"family": "Kuroda", "given": "Keisuke", "initials": "K"}, {"family": "Patel", "given": "Arbind Kumar", "initials": "AK"}, {"family": "Patel", "given": "Nidhi", "initials": "N"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Joshi", "given": "Madhvi", "initials": "M"}, {"family": "Joshi", "given": "Chaitanya G", "initials": "CG"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "issn-l": "0048-9697", "volume": "754", "issue": null, "pages": "142329"}, "abstract": "For the first time, we present, i) an account of decay in the genetic material loading of SARS-CoV-2 during Upflow Anaerobic Sludge Blanket (UASB) treatment of wastewater, and ii) comparative evaluation of polyethylene glycol (PEG), and ultrafiltration as virus concentration methods from wastewater for the quantification of SARS-CoV-2 genes. The objectives were achieved through tracking of SARS-CoV-2 genetic loadings i.e. ORF1ab, N and S protein genes on 8th and 27th May 2020 along the wastewater treatment plant (106000 m 3 million liters per day) equipped with UASB system in Ahmedabad, India. PEG method performed better in removing materials inhibiting RT-qPCR for SARS-CoV-2 gene detection from the samples, as evident from constant and lower CT values of control (MS2). Using the PEG method, we found a reduction >1.3 log10 reduction in SARS-CoV-2 RNA abundance during UASB treatment, and the RNA was not detected at all in the final effluent. The study implies that i) conventional wastewater treatment systems is effective in SARS-CoV-2 RNA removal, and ii) UASB system significantly reduces SARS-CoV-2 genetic loadings. Finally, PEG method is recommended for better sensitivity and inhibition removal during SARS-CoV-2 RNA quantification in wastewater.", "doi": "10.1016/j.scitotenv.2020.142329", "pmid": "33254951", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(20)35858-7"}], "notes": [], "created": "2020-12-03T08:20:09.557Z", "modified": "2021-02-26T08:46:12.935Z"}, {"entity": "publication", "iuid": "098cd3e85b5d489bbab5e2dbb82d2f33", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/098cd3e85b5d489bbab5e2dbb82d2f33.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/098cd3e85b5d489bbab5e2dbb82d2f33"}}, "title": "Assessment of Suicide in Japan During the COVID-19 Pandemic vs Previous Years.", "authors": [{"family": "Sakamoto", "given": "Haruka", "initials": "H"}, {"family": "Ishikane", "given": "Masahiro", "initials": "M"}, {"family": "Ghaznavi", "given": "Cyrus", "initials": "C"}, {"family": "Ueda", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2021-02-01", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "issn-l": null, "volume": "4", "issue": "2", "pages": "e2037378"}, "abstract": "There are concerns that suicide rates may have increased during the coronavirus disease 2019 (COVID-19) pandemic.\r\n\r\nTo assess whether suicide rates in Japan increased in April through November 2020 compared with previous years.\r\n\r\nThis cross-sectional study used national data obtained from the Ministry of Health, Labor and Welfare from 2016 to 2020 on the monthly number of individuals who died of suicide in Japan from January to November of 2016 to 2020.\r\n\r\n2020 vs previous years.\r\n\r\nThe main outcome was monthly suicide rates, calculated as the number of individuals who died of suicide divided by the total population. A difference-in-difference regression model was used to estimate the change in monthly suicide rates in April to November 2020 vs these months in 2016 to 2019.\r\n\r\nAnalyses included 90 048 individuals (61 366 [68.1%] men) who died of suicide from 2016 to 2020. The difference-in-difference analysis of men showed that there was no increase in suicide rates from April through September 2020 compared with these months in 2016 to 2019, but that suicide rates were increased in October (difference-in-difference, 0.40 [95% CI, 0.14 to 0.67] suicide deaths per 100 000 population) and November (difference-in-difference, 0.34 [95% CI, 0.07 to 0.60] suicide deaths per 100 000 population). Among women, suicide rates in 2020 compared with 2016 to 2019 increased in July (difference-in-difference, 0.24 [95% CI, 0.09 to 0.38] suicide deaths per 100 000 population), August (difference-in-difference, 0.30 [95% CI, 0.16 to 0.45] suicide deaths per 100 000 population), September (difference-in-difference, 0.29 [95% CI, 0.15 to 0.44] suicide deaths per 100 000 population), October (difference-in-difference, 0.62 [95% CI, 0.48 to 0.77] suicide deaths per 100 000 population), and November (difference-in-difference, 0.29 [95% CI, 0.15 to 0.44] suicide deaths per 100 000 population). In secondary analyses in which the suicide rates of 2020 were compared with the expected rates based on trends from 2011 to 2019, the increases in suicide rates were most pronounced among men aged younger than 30 years (eg, November: observed vs expected rate ratio [RR], 1.48 [95% CI, 1.26-1.71]) and women aged younger than 30 years (eg, October: observed vs expected RR, 2.14 [95% CI, 1.76 to 2.52]) and 30 to 49 years (eg, October: observed vs expected RR, 2.30 [95% CI, 2.01 to 2.58]).\r\n\r\nThese findings suggest that compared with previous years, suicide rates in Japan in 2020 increased in October and November for men and in July through November for women.", "doi": "10.1001/jamanetworkopen.2020.37378", "pmid": "33528554", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "2775740"}], "notes": [], "created": "2021-02-04T18:23:24.857Z", "modified": "2021-06-18T11:16:04.908Z"}, {"entity": "publication", "iuid": "ddbf17922ce142488599dc803aded789", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ddbf17922ce142488599dc803aded789.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ddbf17922ce142488599dc803aded789"}}, "title": "Risk of Severe Covid-19 in Patients with Celiac Disease: A Population-Based Cohort Study", "authors": [{"family": "Lebwohl", "given": "Benjamin", "initials": "B"}, {"family": "Larsson", "given": "Emma", "initials": "E"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Roelstraete", "given": "Bjorn", "initials": "B"}, {"family": "Murray", "given": "Joseph A", "initials": "JA"}, {"family": "Green", "given": "Peter HR", "initials": "PH"}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "journal-article", "published": "2021-02-00", "journal": {"title": "CLEP", "issn": "1179-1349", "volume": "Volume 13", "issue": null, "pages": "121-130", "issn-l": null}, "abstract": null, "doi": "10.2147/clep.s294391", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-25T12:30:09.922Z", "modified": "2021-02-26T08:47:00.236Z"}, {"entity": "publication", "iuid": "1d63ea6dcd2544f9b0421a69d04ab013", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d63ea6dcd2544f9b0421a69d04ab013.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d63ea6dcd2544f9b0421a69d04ab013"}}, "title": "Reflections on Virtual Care for Chronic Conditions During the COVID-19 Pandemic.", "authors": [{"family": "Wittmeier", "given": "Kristy D M", "initials": "KDM"}, {"family": "Protudjer", "given": "Jennifer L P", "initials": "JLP"}, {"family": "Wicklow", "given": "Brandy A", "initials": "BA"}], "type": "editorial", "published": "2021-02-00", "journal": {"title": "Can J Diabetes", "issn": "2352-3840", "volume": "45", "issue": "1", "pages": "1-2", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jcjd.2020.11.013", "pmid": "33500126", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1499-2671(20)30468-8"}], "notes": [], "created": "2021-01-29T15:20:38.702Z", "modified": "2021-01-29T15:20:38.727Z"}, {"entity": "publication", "iuid": "6cad7393922b4bdab063ef4a5b4e2db5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6cad7393922b4bdab063ef4a5b4e2db5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6cad7393922b4bdab063ef4a5b4e2db5"}}, "title": "Presymptomatic viral shedding and infective ability of SARS-CoV-2; a case report.", "authors": [{"family": "Nissen", "given": "Karolina", "initials": "K"}, {"family": "Hagbom", "given": "Marie", "initials": "M"}, {"family": "Krambrich", "given": "Janina", "initials": "J"}, {"family": "Akaberi", "given": "Dario", "initials": "D"}, {"family": "Sharma", "given": "Sumit", "initials": "S"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Svensson", "given": "Lennart", "initials": "L"}, {"family": "Bondeson", "given": "K\u00e5re", "initials": "K"}, {"family": "Salaneck", "given": "Erik", "initials": "E"}], "type": "case reports", "published": "2021-02-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "issn-l": null, "volume": "7", "issue": "2", "pages": "e06328"}, "abstract": "Possible pre- or asymptomatic transmission has been reported, both from SARS-CoV and from MERS-CoV outbreaks, although this appears to be uncommon. In contrast, during the COVID-19 pandemic, an increasing number of studies and case reports indicate that pre- or asymptomatic transmission of SARS-CoV-2 is not only possible but also occurs frequently. We report repeated rRT-PCR detection of SARS-CoV-2 in a health care worker and demonstrate infective ability up to three days prior to mild COVID-19 symptoms. rRT-PCR indicated high viral levels approximately three days after exposure. Viral samples collected one and three days prior to symptoms exhibited infectivity on Vero E6 cells, confirmed by detection of double-stranded RNA by immunofluorescence, assessment of cytopathic effect (CPE) and rRT-PCR. SARS-CoV-2 specific IgM and IgG antibodies were detected by day 9 and 15, respectively, after symptom onset. We propose that this provides evidence for potential early presymptomatic transmission of SARS-CoV-2 and that infectivity may be manifest shortly after exposure.", "doi": "10.1016/j.heliyon.2021.e06328", "pmid": "33644482", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)00433-3"}, {"db": "pmc", "key": "PMC7894094"}], "notes": [], "created": "2021-03-02T06:53:25.256Z", "modified": "2021-06-18T11:15:39.188Z"}, {"entity": "publication", "iuid": "69841acb8a304e629226b7c50efe0667", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69841acb8a304e629226b7c50efe0667.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69841acb8a304e629226b7c50efe0667"}}, "title": "Point of view on the vaccination against COVID-19 in patients with autoimmune inflammatory rheumatic diseases.", "authors": [{"family": "Furer", "given": "Victoria", "initials": "V", "orcid": "0000-0001-5193-4207", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/17050dc675254cd59533c6568f60db38.json"}}, {"family": "Rondaan", "given": "Christien", "initials": "C", "orcid": "0000-0002-4558-1270", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7a1288a4e4e54e2380de0649962e0322.json"}}, {"family": "Agmon-Levin", "given": "Nancy", "initials": "N"}, {"family": "van Assen", "given": "Sander", "initials": "S"}, {"family": "Bijl", "given": "Marc", "initials": "M"}, {"family": "Kapetanovic", "given": "Meliha Crnkic", "initials": "MC"}, {"family": "de Thurah", "given": "Annette", "initials": "A", "orcid": "0000-0003-0103-4328", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2450d24c34eb4edeb270e0b576635a12.json"}}, {"family": "Mueller-Ladner", "given": "Ulf", "initials": "U"}, {"family": "Paran", "given": "Daphna", "initials": "D"}, {"family": "Schreiber", "given": "Karen", "initials": "K"}, {"family": "Warnatz", "given": "Klaus", "initials": "K"}, {"family": "Wulffraat", "given": "Nico M", "initials": "NM"}, {"family": "Elkayam", "given": "Ori", "initials": "O"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "RMD Open", "issn": "2056-5933", "volume": "7", "issue": "1", "pages": "e001594", "issn-l": null}, "abstract": "In view of the COVID-19 pandemic, there is an unmet clinical need for the guidelines on vaccination of patients with autoimmune inflammatory rheumatic diseases (AIIRD). This position paper summarises the current data on COVID-19 infection in patients with AIIRD and development of vaccines against COVID-19, discusses the aspects of efficacy and safety of vaccination, and proposes preliminary considerations on vaccination against COVID-19 in patients with AIIRD, mainly based on the expert opinion and knowledge on the use of other vaccines in this population of patients.", "doi": "10.1136/rmdopen-2021-001594", "pmid": "33627440", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "rmdopen-2021-001594"}, {"db": "pmc", "key": "PMC7907831"}], "notes": [], "created": "2021-02-25T14:57:13.800Z", "modified": "2021-07-14T07:52:36.535Z"}, {"entity": "publication", "iuid": "487865ba9e4b446b9097b0d17ff1ecb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/487865ba9e4b446b9097b0d17ff1ecb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/487865ba9e4b446b9097b0d17ff1ecb1"}}, "title": "Persistence of IgG response to SARS-CoV-2.", "authors": [{"family": "Duysburgh", "given": "Els", "initials": "E"}, {"family": "Mortgat", "given": "Laure", "initials": "L"}, {"family": "Barbezange", "given": "Cyril", "initials": "C"}, {"family": "Dierick", "given": "Katelijne", "initials": "K"}, {"family": "Fischer", "given": "Natalie", "initials": "N"}, {"family": "Heyndrickx", "given": "Leo", "initials": "L"}, {"family": "Hutse", "given": "Veronik", "initials": "V"}, {"family": "Thomas", "given": "Isabelle", "initials": "I"}, {"family": "Van Gucht", "given": "Steven", "initials": "S"}, {"family": "Vuylsteke", "given": "Bea", "initials": "B"}, {"family": "Ari\u00ebn", "given": "Kevin K", "initials": "KK"}, {"family": "Desombere", "given": "Isabelle", "initials": "I"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "issn-l": null, "volume": "21", "issue": "2", "pages": "163-164"}, "abstract": null, "doi": "10.1016/S1473-3099(20)30943-9", "pmid": "33341124", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(20)30943-9"}, {"db": "pmc", "key": "PMC7833610"}], "notes": [], "created": "2021-01-10T18:08:16.831Z", "modified": "2021-07-14T07:49:21.276Z"}, {"entity": "publication", "iuid": "a4dcb004fb8140fbb690fb73057e327e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a4dcb004fb8140fbb690fb73057e327e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a4dcb004fb8140fbb690fb73057e327e"}}, "title": "Pediatric COVID-19 Cases Prelockdown and Postlockdown in Italy.", "authors": [{"family": "Bellino", "given": "Stefania", "initials": "S"}, {"family": "Rota", "given": "Maria Cristina", "initials": "MC"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Mateo Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Punzo", "given": "Ornella", "initials": "O"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Villani", "given": "Alberto", "initials": "A"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "COVID-19 Working Group", "given": "", "initials": ""}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Pediatrics", "issn": "1098-4275", "volume": "147", "issue": "2", "issn-l": null}, "abstract": null, "doi": "10.1542/peds.2020-035238", "pmid": "33154154", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "peds.2020-035238"}], "notes": [], "created": "2021-02-10T18:54:40.193Z", "modified": "2021-02-26T08:47:00.137Z"}, {"entity": "publication", "iuid": "2f959e159f0a4064b0bf49d2d8f84427", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2f959e159f0a4064b0bf49d2d8f84427.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2f959e159f0a4064b0bf49d2d8f84427"}}, "title": "Online health survey research during COVID-19", "authors": [{"family": "Hlatshwako", "given": "Takhona G", "initials": "TG"}, {"family": "Shah", "given": "Sonam J", "initials": "SJ"}, {"family": "Kosana", "given": "Priya", "initials": "P"}, {"family": "Adebayo", "given": "Emmanuel", "initials": "E"}, {"family": "Hendriks", "given": "Jacqueline", "initials": "J"}, {"family": "Larsson", "given": "Elin C", "initials": "EC"}, {"family": "Hensel", "given": "Devon J", "initials": "DJ"}, {"family": "Erausquin", "given": "Jennifer Toller", "initials": "JT"}, {"family": "Marks", "given": "Michael", "initials": "M"}, {"family": "Michielsen", "given": "Kristien", "initials": "K"}, {"family": "Saltis", "given": "Hanna", "initials": "H"}, {"family": "Francis", "given": "Joel M", "initials": "JM"}, {"family": "Wouters", "given": "Edwin", "initials": "E"}, {"family": "Tucker", "given": "Joseph D", "initials": "JD"}], "type": "journal-article", "published": "2021-02-00", "journal": {"title": "The Lancet Digital Health", "issn": "2589-7500", "issn-l": null, "volume": "3", "issue": "2", "pages": "e76-e77"}, "abstract": null, "doi": "10.1016/s2589-7500(21)00002-9", "pmid": "33509387", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-29T15:11:39.497Z", "modified": "2021-02-15T19:17:59.351Z"}, {"entity": "publication", "iuid": "8662c05a2e6c4dab89413bfd6652c32e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8662c05a2e6c4dab89413bfd6652c32e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8662c05a2e6c4dab89413bfd6652c32e"}}, "title": "Lingonberry polyphenols: Potential SARS-CoV-2 inhibitors as nutraceutical tools?", "authors": [{"family": "P\u00e4rn\u00e4nen", "given": "Pirjo", "initials": "P"}, {"family": "L\u00e4hteenm\u00e4ki", "given": "Hanna", "initials": "H"}, {"family": "R\u00e4is\u00e4nen", "given": "Ismo", "initials": "I"}, {"family": "Tervahartiala", "given": "Taina", "initials": "T"}, {"family": "Sorsa", "given": "Timo", "initials": "T"}], "type": "letter", "published": "2021-02-00", "journal": {"title": "Physiol Rep", "issn": "2051-817X", "volume": "9", "issue": "3", "pages": "e14741", "issn-l": null}, "abstract": "Proposed pathway of the effect of lingonberry polyphenols on oral microbial (viral) load reduction and consequent beneficial local and systemic (respiratory tract) anti-inflammatory and antimicrobial/antiviral effects.", "doi": "10.14814/phy2.14741", "pmid": "33527774", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-04T18:23:55.661Z", "modified": "2021-02-04T18:23:55.683Z"}, {"entity": "publication", "iuid": "fd6a374bb2da4ca3b85dacb8f68a68a5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fd6a374bb2da4ca3b85dacb8f68a68a5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fd6a374bb2da4ca3b85dacb8f68a68a5"}}, "title": "Leveraging epidemiological principles to evaluate Sweden's COVID-19 response.", "authors": [{"family": "Baral", "given": "Stefan", "initials": "S"}, {"family": "Chandler", "given": "Rebecca", "initials": "R"}, {"family": "Prieto", "given": "Ruth Gil", "initials": "RG"}, {"family": "Gupta", "given": "Sunetra", "initials": "S"}, {"family": "Mishra", "given": "Sharmistha", "initials": "S"}, {"family": "Kulldorff", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Ann Epidemiol", "issn": "1873-2585", "volume": "54", "issue": null, "pages": "21-26", "issn-l": null}, "abstract": "In the response to COVID-19, countries have implemented response strategies along a continuum of population- and venue-level specificity ranging from suppression to mitigation strategies. Suppression strategies generally include population-wide shelter-in-place mandates or lockdowns, closure of nonessential physical venues, travel bans, testing and contact tracing, and quarantines. Sweden followed a mitigation strategy focused on risk-tailored approaches to mitigate specific acquisition risks among the elderly, minimizing the disruption to education and the delivery of other health care services, and recommendations for social distancing to minimize the disease burden. To date, Sweden has reported higher case counts and attributable mortality than other Scandinavian countries and lower than other Northern European countries. However, there are several limitations with comparison given heterogeneity in testing strategies, suspected and confirmed case definitions, and assessment of attributable mortality. The decisions in Sweden also reflect social priorities such as equity being a foundational principle of Swedish social systems. Consistently, in-person education for those aged less than 16 years continued throughout. Notably, the mitigation strategy did not eliminate the inequitable impacts of COVID-19 cases and mortality in Sweden with higher-exposure and generally lower-income occupations being associated with higher risks intersecting with these communities often residing in more dense multigenerational households. From January 1 to November 15, there has been a 1.8% increase in all-cause mortality in 2020 compared with the average of 2015-2019, representing an excess of 14.3 deaths per 100,000 population. However, the final assessment of excess deaths in Sweden in 2020 including stratification by age and integration of secular trends can only be calculated in the coming years. In response to increasing cases in the fall of 2020, Sweden has continued to leverage business-oriented regulations and public-oriented guidelines for social distancing rather than police-enforced mandates. Ultimately, pandemics present no winners. Countries have implemented a range of different COVID-19 prevention and mitigation strategies responsive to their own priorities and legal systems including equity and the balancing of competing health priorities. Given these varied approaches, countries that pursued elimination, suppression, or mitigation strategies can collaboratively learn from both successes and challenges of the different strategies to inform COVID-19 and future pandemic responses.", "doi": "10.1016/j.annepidem.2020.11.005", "pmid": "33242596", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7682427"}, {"db": "pii", "key": "S1047-2797(20)30413-0"}], "notes": [], "created": "2020-11-30T07:46:01.828Z", "modified": "2023-01-13T13:27:50.907Z"}, {"entity": "publication", "iuid": "7d8d997669864c078e5036277c77f2c4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d8d997669864c078e5036277c77f2c4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d8d997669864c078e5036277c77f2c4"}}, "title": "Just allocation of COVID-19 vaccines.", "authors": [{"family": "Herlitz", "given": "Anders", "initials": "A"}, {"family": "Lederman", "given": "Zohar", "initials": "Z"}, {"family": "Miller", "given": "Jennifer", "initials": "J"}, {"family": "Fleurbaey", "given": "Marc", "initials": "M"}, {"family": "Venkatapuram", "given": "Sridhar", "initials": "S"}, {"family": "Atuire", "given": "Caesar", "initials": "C"}, {"family": "Eckenwiler", "given": "Lisa", "initials": "L"}, {"family": "Hassoun", "given": "Nicole", "initials": "N"}], "type": "editorial", "published": "2021-02-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "2", "issn-l": "2059-7908"}, "abstract": null, "doi": "10.1136/bmjgh-2020-004812", "pmid": "33589419", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-004812"}], "notes": [], "created": "2021-02-17T14:52:59.770Z", "modified": "2021-02-17T14:53:17.075Z"}, {"entity": "publication", "iuid": "9b83ecfd2cf74c0fb5506f4188b70b13", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b83ecfd2cf74c0fb5506f4188b70b13.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b83ecfd2cf74c0fb5506f4188b70b13"}}, "title": "Indirect acute effects of the COVID-19 pandemic on physical and mental health in the UK: a population-based study", "authors": [{"family": "Mansfield", "given": "Kathryn E", "initials": "KE"}, {"family": "Mathur", "given": "Rohini", "initials": "R"}, {"family": "Tazare", "given": "John", "initials": "J"}, {"family": "Henderson", "given": "Alasdair D", "initials": "AD"}, {"family": "Mulick", "given": "Amy R", "initials": "AR"}, {"family": "Carreira", "given": "Helena", "initials": "H"}, {"family": "Matthews", "given": "Anthony A", "initials": "AA"}, {"family": "Bidulka", "given": "Patrick", "initials": "P"}, {"family": "Gayle", "given": "Alicia", "initials": "A"}, {"family": "Forbes", "given": "Harriet", "initials": "H"}, {"family": "Cook", "given": "Sarah", "initials": "S"}, {"family": "Wong", "given": "Angel Y S", "initials": "AYS"}, {"family": "Strongman", "given": "Helen", "initials": "H"}, {"family": "Wing", "given": "Kevin", "initials": "K"}, {"family": "Warren-Gash", "given": "Charlotte", "initials": "C"}, {"family": "Cadogan", "given": "Sharon L", "initials": "SL"}, {"family": "Smeeth", "given": "Liam", "initials": "L"}, {"family": "Hayes", "given": "Joseph F", "initials": "JF"}, {"family": "Quint", "given": "Jennifer K", "initials": "JK"}, {"family": "McKee", "given": "Martin", "initials": "M"}, {"family": "Langan", "given": "Sin\u00e9ad M", "initials": "SM"}], "type": "journal-article", "published": "2021-02-00", "journal": {"title": "The Lancet Digital Health", "issn": "2589-7500", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/s2589-7500(21)00017-0", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-22T14:10:45.560Z", "modified": "2021-06-18T11:41:19.983Z"}, {"entity": "publication", "iuid": "7a750b50ba814141b855b6ad3efb4c8e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a750b50ba814141b855b6ad3efb4c8e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a750b50ba814141b855b6ad3efb4c8e"}}, "title": "Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients.", "authors": [{"family": "B\u00fclow Anderberg", "given": "Sara", "initials": "S"}, {"family": "Luther", "given": "Tomas", "initials": "T"}, {"family": "Berglund", "given": "Malin", "initials": "M"}, {"family": "Larsson", "given": "Rolf", "initials": "R"}, {"family": "Rubertsson", "given": "Sten", "initials": "S"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Cytokine", "issn": "1043-4666", "issn-l": null, "volume": "138", "issue": null, "pages": "155389"}, "abstract": "The infection caused by SARS CoV-2 has been postulated to induce a cytokine storm syndrome that results in organ failure and even death in a considerable number of patients. However, the inflammatory response in Corona virus disease-19 (Covid-19) and its potential to cause collateral organ damage has not been fully elucidated to date. This study aims to characterize the acute cytokine response in a cohort of critically ill Covid-19 patients.\r\n\r\n24 adults with PCR-confirmed Covid-19 were included at time of admission to intensive care a median of eleven days after initial symptoms. Eleven adult patients admitted for elective abdominal surgery with preoperative plasma samples served as controls. All patients were included after informed consent was obtained. 27 cytokines were quantified in plasma. The expression of inflammatory mediators was then related to routine inflammatory markers, SAPS3, SOFA score, organ failure and 30-day mortality.\r\n\r\nA general increase in cytokine expression was observed in all Covid-19 patients. A strong correlation between respiratory failure and IL-1ra, IL-4, IL-6, IL-8 and IP-10 expression was observed. Acute kidney injury development correlated well with increased levels of IL-1ra, IL-6, IL-8, IL-17a, IP-10 and MCP-1. Generally, the cohort demonstrated weaker correlations between cytokine expression and 30-day mortality out of which IL-8 showed the strongest signal in terms of mortality.\r\n\r\nThe present study found that respiratory failure, acute kidney injury and 30-day mortality in critically ill Covid-19 patients are associated with moderate increases of a broad range of inflammatory mediators at time of admission.", "doi": "10.1016/j.cyto.2020.155389", "pmid": "33348065", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1043-4666(20)30405-1"}, {"db": "pmc", "key": "PMC7833204"}], "notes": [], "created": "2020-12-22T11:23:41.897Z", "modified": "2021-06-11T14:26:41.341Z"}, {"entity": "publication", "iuid": "c5b8fd169aca45b880a478c279cf0888", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5b8fd169aca45b880a478c279cf0888.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5b8fd169aca45b880a478c279cf0888"}}, "title": "EHA/ESMO Clinical Practice Guidelines for the Management of Malignant Lymphoma: Recommendations for the Second Phase of the COVID-19 Pandemic.", "authors": [{"family": "Dreyling", "given": "Martin", "initials": "M"}, {"family": "Aurer", "given": "Igor", "initials": "I"}, {"family": "Federico", "given": "Massimo", "initials": "M"}, {"family": "Jerkeman", "given": "Mats", "initials": "M"}, {"family": "Kersten", "given": "Marie Jose", "initials": "MJ"}, {"family": "Linton", "given": "Kim", "initials": "K"}, {"family": "Mey", "given": "Ulrich", "initials": "U"}, {"family": "Tilly", "given": "Herve", "initials": "H"}, {"family": "Buske", "given": "Christian", "initials": "C"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Hemasphere", "issn": "2572-9241", "volume": "5", "issue": "2", "pages": "e529", "issn-l": null}, "abstract": null, "doi": "10.1097/HS9.0000000000000529", "pmid": "33880434", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC8051991"}], "notes": [], "created": "2021-04-23T04:38:11.381Z", "modified": "2021-04-23T04:38:11.403Z"}, {"entity": "publication", "iuid": "3632e818c24f4aaf9db49ba11d5b8c07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3632e818c24f4aaf9db49ba11d5b8c07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3632e818c24f4aaf9db49ba11d5b8c07"}}, "title": "Does antipsychotic use mediate the effect of psychiatric disorders on COVID-19? - Authors' reply.", "authors": [{"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Chen", "given": "Wenwen", "initials": "W"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Lancet Healthy Longev", "issn": "2666-7568", "volume": "2", "issue": "2", "pages": "e65", "issn-l": null}, "abstract": null, "doi": "10.1016/S2666-7568(21)00007-6", "pmid": "33665643", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2666-7568(21)00007-6"}, {"db": "pmc", "key": "PMC7906648"}], "notes": [], "created": "2021-03-06T10:11:40.785Z", "modified": "2021-03-06T10:11:40.793Z"}, {"entity": "publication", "iuid": "2ec0095a0ee14c30aea469610f0c14ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ec0095a0ee14c30aea469610f0c14ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ec0095a0ee14c30aea469610f0c14ef"}}, "title": "Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19.", "authors": [{"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/305bca9e5c6c423898c272bf06ce2f2a.json"}}, {"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f28f2f6ac9648629c2d2de92fe7bb59.json"}}, {"family": "Rosell", "given": "Axel", "initials": "A", "orcid": "0000-0001-6280-0562", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4da18c480a2d4c80ad6c7d1f97bbf917.json"}}, {"family": "Aguilera", "given": "Katherina", "initials": "K"}, {"family": "Parv", "given": "Kristel", "initials": "K", "orcid": "0000-0002-1238-9338", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c21024fbb7f447db8879b36373e00bae.json"}}, {"family": "von Meijenfeldt", "given": "Fien A", "initials": "FA", "orcid": "0000-0003-0274-2414", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76b5cb67f6e243459441f06d41f0816c.json"}}, {"family": "Lisman", "given": "Ton", "initials": "T", "orcid": "0000-0002-3503-7140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7431e810d13c443ca5dacbf5d368e60b.json"}}, {"family": "Mackman", "given": "Nigel", "initials": "N", "orcid": "0000-0002-9170-7700", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/979eb3bfd39f407ba1f0359140d215fd.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1345-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a53a433db6f04a458e3d420f0c9995c5.json"}}, {"family": "Phillipson", "given": "Mia", "initials": "M", "orcid": "0000-0002-2387-0266", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/614a4a6f69204c6287a81a79a1a7a8f1.json"}}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Arterioscler Thromb Vasc Biol", "issn": "1524-4636", "issn-l": null, "volume": "41", "issue": "2", "pages": "988-994"}, "abstract": "The full spectrum of coronavirus disease 2019 (COVID-19) infection ranges from asymptomatic to acute respiratory distress syndrome, characterized by hyperinflammation and thrombotic microangiopathy. The pathogenic mechanisms are poorly understood, but emerging evidence suggest that excessive neutrophil extracellular trap (NET) formation plays a key role in COVID-19 disease progression. Here, we evaluate if circulating markers of NETs are associated with COVID-19 disease severity and clinical outcome, as well as to markers of inflammation and in vivo coagulation and fibrinolysis. Approach and Results: One hundred six patients with COVID-19 with moderate to severe disease were enrolled shortly after hospital admission and followed for 4 months. Acute and convalescent plasma samples as well as plasma samples from 30 healthy individuals were assessed for markers of NET formation: citrullinated histone H3, cell-free DNA, NE (neutrophil elastase). We found that all plasma levels of NET markers were elevated in patients with COVID-19 relative to healthy controls, that they were associated with respiratory support requirement and short-term mortality, and declined to those found in healthy individuals 4 months post-infection. The levels of the NET markers also correlated with white blood cells, neutrophils, inflammatory cytokines, and C-reactive protein, as well as to markers of in vivo coagulation, fibrinolysis, and endothelial damage.\n\nOur findings suggest a role of NETs in COVID-19 disease progression, implicating their contribution to an immunothrombotic state. Further, we observed an association between circulating markers of NET formation and clinical outcome, demonstrating a potential role of NET markers in clinical decision-making, as well as for NETs as targets for novel therapeutic interventions in COVID-19.", "doi": "10.1161/ATVBAHA.120.315267", "pmid": "33267662", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7837697"}], "notes": [], "created": "2020-12-04T09:03:17.375Z", "modified": "2022-02-14T15:55:21.457Z"}, {"entity": "publication", "iuid": "5f2c59b02c4d48a983071ac076b60ca1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f2c59b02c4d48a983071ac076b60ca1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f2c59b02c4d48a983071ac076b60ca1"}}, "title": "COVID-19: investing in country capacity to bridge science, policy and action.", "authors": [{"family": "Kuchenm\u00fcller", "given": "Tanja", "initials": "T"}, {"family": "Reeder", "given": "John C", "initials": "JC"}, {"family": "Reveiz", "given": "Ludovic", "initials": "L"}, {"family": "Tomson", "given": "Goran", "initials": "G"}, {"family": "El-Jardali", "given": "Fadi", "initials": "F"}, {"family": "Lavis", "given": "John N", "initials": "JN"}, {"family": "Rashidian", "given": "Arash", "initials": "A"}, {"family": "Reinap", "given": "Marge", "initials": "M"}, {"family": "Grove", "given": "John T", "initials": "JT"}, {"family": "Swaminathan", "given": "Soumya", "initials": "S"}], "type": "editorial", "published": "2021-02-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "issn-l": "2059-7908", "volume": "6", "issue": "2", "pages": null}, "abstract": null, "doi": "10.1136/bmjgh-2021-005012", "pmid": "33597281", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2021-005012"}], "notes": [], "created": "2021-02-19T06:20:07.200Z", "modified": "2021-02-19T06:20:17.002Z"}, {"entity": "publication", "iuid": "624e15eacaa642b18cc1953db10887fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/624e15eacaa642b18cc1953db10887fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/624e15eacaa642b18cc1953db10887fd"}}, "title": "COVID-19: Opportunities for interdisciplinary research to improve care for older people in Sweden.", "authors": [{"family": "Baxter", "given": "Rebecca", "initials": "R", "orcid": "0000-0001-6595-6298", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/446ab62637de405fa4042d961cedbe36.json"}}, {"family": "Jemberie", "given": "Wossenseged Birhane", "initials": "WB", "orcid": "0000-0002-4378-6803", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e7b6e3bb364489288767124c08f43e9.json"}}, {"family": "Li", "given": "Xia", "initials": "X"}, {"family": "Naseer", "given": "Mahwish", "initials": "M"}, {"family": "Pauelsen", "given": "Mascha", "initials": "M", "orcid": "0000-0002-2510-7571", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/461406e7a70a44168b097af43b4052e9.json"}}, {"family": "Shebehe", "given": "Jacques", "initials": "J", "orcid": "0000-0002-0044-0781", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/361987c728f64fbe95ef1c303417aeba.json"}}, {"family": "Viklund", "given": "Emilia W E", "initials": "EWE", "orcid": "0000-0002-5852-1381", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/be19480279de4195b28af1bfe2c692ff.json"}}, {"family": "Xia", "given": "Xin", "initials": "X"}, {"family": "Zulka", "given": "Linn Elena", "initials": "LE"}, {"family": "Badache", "given": "Andreea", "initials": "A"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "volume": "49", "issue": "1", "pages": "29-32", "issn-l": "1403-4948"}, "abstract": "The emergence of COVID-19 has changed the world as we know it, arguably none more so than for older people. In Sweden, the majority of COVID-19-related fatalities have been among people aged \u2a7e70 years, many of whom were receiving health and social care services. The pandemic has illuminated aspects within the care continuum requiring evaluative research, such as decision-making processes, the structure and organisation of care, and interventions within the complex public-health system. This short communication highlights several key areas for future interdisciplinary and multi-sectorial collaboration to improve health and social care services in Sweden. It also underlines that a valid, reliable and experiential evidence base is the sine qua non for evaluative research and effective public-health systems.", "doi": "10.1177/1403494820969544", "pmid": "33161880", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7859561"}], "notes": [], "created": "2020-11-27T10:06:14.801Z", "modified": "2023-01-13T13:42:48.947Z"}, {"entity": "publication", "iuid": "7aaaa58539d848c588572b55511cd93a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7aaaa58539d848c588572b55511cd93a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7aaaa58539d848c588572b55511cd93a"}}, "title": "An analytical study of drug utilization, disease progression, and adverse events among 165 COVID-19 patients.", "authors": [{"family": "Sun", "given": "Feng", "initials": "F"}, {"family": "Kou", "given": "Hao", "initials": "H"}, {"family": "Wang", "given": "Shengfeng", "initials": "S"}, {"family": "Lu", "given": "Yun", "initials": "Y"}, {"family": "Zhao", "given": "Houyu", "initials": "H"}, {"family": "Li", "given": "Wenjing", "initials": "W"}, {"family": "Zhou", "given": "Qingxin", "initials": "Q"}, {"family": "Jiang", "given": "Qiaoli", "initials": "Q"}, {"family": "Cheng", "given": "Yinchu", "initials": "Y"}, {"family": "Yang", "given": "Kun", "initials": "K"}, {"family": "Zhuo", "given": "Lin", "initials": "L"}, {"family": "Xu", "given": "Yang", "initials": "Y"}, {"family": "Wu", "given": "Dongfang", "initials": "D"}, {"family": "Zhan", "given": "Siyan", "initials": "S"}, {"family": "Cheng", "given": "Hong", "initials": "H"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Ann Transl Med", "issn": "2305-5839", "volume": "9", "issue": "4", "pages": "306", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) epidemic has lasted for nearly 4 months by this study was conducted. We aimed to describe drug utilization, disease progression, and adverse drug events of COVID-19.\n\nA retrospective, single-center case series study enrolled 165 consecutive hospitalized COVID-19 patients who were followed up until March 25, 2020, from a designated hospital in Wuhan. Patients were grouped by a baseline degree of severity: non-severe and severe. An analytical study of drug utilization, disease progression, and adverse events (AEs) of COVID-19 was conducted.\n\nOf the 165 COVID-19 cases, antivirals, antibacterials, glucocorticoids, and traditional Chinese medicine (TCM) were administered to 92.7%, 98.8%, 68.5%, and 55.2% of patients, respectively. The total kinds of drugs administered to the severe subgroup [26, interquartile range (IQR) 18-39] were 11 more than the non-severe subgroup (15, IQR 10-24), regardless of comorbidities. The 2 most common combinations of medications in the 165 cases were 'antiviral therapy + glucocorticoids + TCM' (81, 49.1%) and 'antiviral therapy + glucocorticoids' (23, 13.9%). Compared with non-severe cases, severe cases received more glucocorticoids (88.5% vs. 66.2%, P=0.02), but less TCM (50.0% vs. 63.3%, P=0.20), and suffered a higher percentage of death (34.6% vs. 7.2%, P=0.001). At the end of the follow-up, 130 (78.8%) patients had been discharged, and 24 (14.5%) died. There were 13 patients (7.9%) who had elevated liver enzymes, and 49 patients (29.7%) presented with worsening kidney function during the follow-up.\n\nOf the 165 COVID-19 patients, the fatality rate remained high (14.5%). Drug utilization for COVID-19 was diverse and generally complied with the existing guidelines. Combination regimens containing antiviral drugs might be beneficial to assist COVID-19 recovery. Additionally, liver and kidney AEs should not be ignored.", "doi": "10.21037/atm-20-4960", "pmid": "33708933", "labels": {"Category: Drug Discovery": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "atm-09-04-306"}, {"db": "pmc", "key": "PMC7944318"}], "notes": [], "created": "2021-03-17T07:19:03.452Z", "modified": "2021-04-14T04:53:53.274Z"}, {"entity": "publication", "iuid": "b7f77ec5886a47618ad2a40f1ed9e96b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b7f77ec5886a47618ad2a40f1ed9e96b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b7f77ec5886a47618ad2a40f1ed9e96b"}}, "title": "A literature survey of the robotic technologies during the COVID-19 pandemic", "authors": [{"family": "Wang", "given": "Xi Vincent", "initials": "XV"}, {"family": "Wang", "given": "Lihui", "initials": "L"}], "type": "journal-article", "published": "2021-02-00", "journal": {"title": "Journal of Manufacturing Systems", "issn": "0278-6125", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Since the late 2019, the COVID-19 pandemic has been spread all around the world. The pandemic is a critical challenge to the health and safety of the general public, the medical staff and the medical systems worldwide. It has been globally proposed to utilise robots during the pandemic, to improve the treatment of patients and leverage the load of the medical system. However, there is still a lack of detailed and systematic review of the robotic research for the pandemic, from the technologies' perspective. Thus a thorough literature survey is conducted in this research and more than 280 publications have been reviewed, with the focus on robotics during the pandemic. The main contribution of this literature survey is to answer two research questions, i.e. 1) what the main research contributions are to combat the pandemic from the robotic technologies' perspective, and 2) what the promising supporting technologies are needed during and after the pandemic to help and guide future robotics research. The current achievements of robotic technologies are reviewed and discussed in different categories, followed by the identification of the representative work's technology readiness level. The future research trends and essential technologies are then highlighted, including artificial intelligence, 5 G, big data, wireless sensor network, and human-robot collaboration.", "doi": "10.1016/j.jmsy.2021.02.005", "pmid": "33612914", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-02-22T14:09:42.828Z", "modified": "2021-03-01T10:31:09.387Z"}, {"entity": "publication", "iuid": "63a879b92bde4fafb933f2c227e84d95", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63a879b92bde4fafb933f2c227e84d95.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63a879b92bde4fafb933f2c227e84d95"}}, "title": "The screening and evaluation of potential clinically significant HIV drug combinations against the SARS-CoV-2 virus.", "authors": [{"family": "Tomi\u0107", "given": "Dra\u0161ko", "initials": "D"}, {"family": "Davidovi\u0107", "given": "Davor", "initials": "D"}, {"family": "Szasz", "given": "Attila Marcel", "initials": "AM"}, {"family": "Rezeli", "given": "Melinda", "initials": "M"}, {"family": "Pirki\u0107", "given": "Boris", "initials": "B"}, {"family": "Petrik", "given": "Jozsef", "initials": "J"}, {"family": "Vrca", "given": "Vesna Ba\u010di\u0107", "initials": "VB"}, {"family": "Jan\u0111el", "given": "Vladimir", "initials": "V"}, {"family": "Lipi\u0107", "given": "Tomislav", "initials": "T"}, {"family": "Skala", "given": "Karolj", "initials": "K"}, {"family": "Mesari\u0107", "given": "Josip", "initials": "J"}, {"family": "Peri\u0161a", "given": "Marija Milkovi\u0107", "initials": "MM"}, {"family": "\u0160ojat", "given": "Zorislav", "initials": "Z"}, {"family": "Rogina", "given": "Branka Medved", "initials": "BM"}], "type": "journal article", "published": "2021-01-30", "journal": {"title": "Inform Med Unlocked", "issn": "2352-9148", "issn-l": null, "volume": "23", "issue": null, "pages": "100529"}, "abstract": "Spike glycoprotein is essential for the reproduction of the SARS-CoV-2 virus, and its inhibition using already approved antiviral drugs may open new avenues for treatment of patients with the COVID-19 disease. Because of that we analyzed the inhibition of SARS-CoV-2 spike glycoprotein with FDA-approved antiviral drugs and their double and triple combinations. We used the Vini in silico model of cancer to perform this virtual drug screening, showing HIV drugs to be the most effective. Besides, the combination of cobicistat-abacavir-rilpivirine HIV drugs demonstrated the highest in silico efficacy of inhibiting SARS-CoV-2 spike glycoprotein. Therefore, a clinical trial of cobicistat-abacavir-rilpivirine on a limited number of COVID-19 patients in moderately severe and severe condition is warranted.", "doi": "10.1016/j.imu.2021.100529", "pmid": "33553571", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S2352-9148(21)00019-8"}, {"db": "pmc", "key": "PMC7847290"}, {"db": "URL", "key": "http://fulir.irb.hr/6161/", "description": "Results of the efficacy of FDA approved antiviral drugs on SARS-CoV-2 spike glycoprotein"}, {"db": "URL", "key": "https://github.com/draskot/Vini", "description": "The Vini in silico model of cancer"}], "notes": [], "created": "2021-02-10T18:47:44.044Z", "modified": "2021-06-21T14:53:11.203Z"}, {"entity": "publication", "iuid": "550f6ada91ba4b7184d5660c34607b68", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/550f6ada91ba4b7184d5660c34607b68.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/550f6ada91ba4b7184d5660c34607b68"}}, "title": "The Development of Swedish Military Healthcare System: Part II-Re-evaluating the Military and Civilian Healthcare Systems in Crises Through a Dialogue and Study Among Practitioners.", "authors": [{"family": "Khorram-Manesh", "given": "Amir", "initials": "A", "orcid": "0000-0002-2734-5733", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1c1cf8fb45614882aa1817af7e3da375.json"}}, {"family": "Burkle", "given": "Frederick M", "initials": "FM"}, {"family": "Phattharapornjaroen", "given": "Phatthranit", "initials": "P"}, {"family": "Ahmadi Marzaleh", "given": "Milad", "initials": "M"}, {"family": "Sultan", "given": "Mohammed Al", "initials": "MA"}, {"family": "M\u00e4ntysaari", "given": "Matti", "initials": "M"}, {"family": "Carlstr\u00f6m", "given": "Eric", "initials": "E"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K", "orcid": "0000-0003-4368-6850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6bbd56fa5d243618a08005b61a9f749.json"}}, {"family": "Santamaria", "given": "Emelia", "initials": "E"}, {"family": "Comandante", "given": "John David", "initials": "JD"}, {"family": "Dobson", "given": "Robert", "initials": "R"}, {"family": "Hreckovski", "given": "Boris", "initials": "B"}, {"family": "Torgersen", "given": "Glenn-Egil", "initials": "GE"}, {"family": "Mortelmans", "given": "Luc J", "initials": "LJ"}, {"family": "de Jong", "given": "Mirjam", "initials": "M"}, {"family": "Robinson", "given": "Yohan", "initials": "Y"}], "type": "journal article", "published": "2021-01-30", "journal": {"title": "Mil Med", "issn": "1930-613X", "volume": "186", "issue": "3-4", "pages": "e442-e450", "issn-l": "0026-4075"}, "abstract": "Historical changes have transformed Sweden from being an offensive to a defensive and collaborative nation with national and international engagement, allowing it to finally achieve the ground for the civilian-military collaboration and the concept of a total defense healthcare. At the same time, with the decreasing number of international and interstate conflicts, and the military's involvement in national emergencies and humanitarian disaster relief, both the need and the role of the military healthcare system within the civilian society have been challenged. The recent impact of the COVID-19 in the USA and the necessity of military involvement have led health practitioners to anticipate and re-evaluate conditions that might exceed the civilian capacity of their own countries and the need to have collaboration with the military healthcare. This study investigated both these challenges and views from practitioners regarding the benefits of such collaboration and the manner in which it would be initiated.\n\nA primary study was conducted among responsive countries using a questionnaire created using the Nominal Group Technique. Relevant search subjects and keywords were extracted for a systematic review of the literature, according to the PRISMA model.\n\nThe 14 countries responding to the questionnaire had either a well-developed military healthcare system or units created in collaboration with the civilian healthcare. The results from the questionnaire and the literature review indicated a need for transfer of military medical knowledge and resources in emergencies to the civilian health components, which in return, facilitated training opportunities for the military staff to maintain their skills and competencies.\n\nAs the world witnesses a rapid change in the etiology of disasters and various crises, neither the military nor the civilian healthcare systems can address or manage the outcomes independently. There is an opportunity for both systems to develop future healthcare in collaboration. Rethinking education and training in war and conflict is indisputable. Collaborative educational initiatives in disaster medicine, public health and complex humanitarian emergencies, international humanitarian law, and the Geneva Convention, along with advanced training in competency-based skill sets, should be included in the undergraduate education of health professionals for the benefit of humanity.", "doi": "10.1093/milmed/usaa364", "pmid": "33135765", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7665683"}, {"db": "pii", "key": "5950402"}], "notes": [], "created": "2020-11-27T11:01:18.112Z", "modified": "2023-06-19T14:41:51.162Z"}, {"entity": "publication", "iuid": "ae2205c49d6349c8ac8f0513a453076f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ae2205c49d6349c8ac8f0513a453076f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ae2205c49d6349c8ac8f0513a453076f"}}, "title": "Resilience and mental health during the COVID-19 pandemic.", "authors": [{"family": "Verdolini", "given": "Norma", "initials": "N"}, {"family": "Amoretti", "given": "Silvia", "initials": "S"}, {"family": "Montejo", "given": "Laura", "initials": "L"}, {"family": "Garc\u00eda-Rizo", "given": "Clemente", "initials": "C"}, {"family": "Hogg", "given": "Bridget", "initials": "B"}, {"family": "Mezquida", "given": "Gisela", "initials": "G"}, {"family": "Rabelo-da-Ponte", "given": "Francisco Diego", "initials": "FD"}, {"family": "Vallespir", "given": "Catalina", "initials": "C"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Martinez-Aran", "given": "Anabel", "initials": "A"}, {"family": "Pacchiarotti", "given": "Isabella", "initials": "I"}, {"family": "Rosa", "given": "Adriane R", "initials": "AR"}, {"family": "Bernardo", "given": "Miguel", "initials": "M"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Torrent", "given": "Carla", "initials": "C"}, {"family": "Sol\u00e9", "given": "Brisa", "initials": "B"}], "type": "journal article", "published": "2021-01-29", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "volume": "283", "issue": null, "pages": "156-164", "issn-l": null}, "abstract": "Resilience is a process that allows recovery from or adaptation to adversities. The aim of this study was to evaluate state resilience during the COVID-19 pandemic in psychiatric patients (PP), unaffected relatives (UR) and community controls (CC).\n\nThis study is part of the Barcelona ResIlience Survey for Mental Health COVID-19 (BRIS-MHC) project. Logistic regression models were performed to identify mental health outcomes associated with bad state resilience and predictors of good state resilience. The association between state resilience and specific affective temperaments as well as their influence on the association between depressive symptoms and state resilience were verified.\n\nThe study recruited 898 participants that took part in the survey. The presence of depressive symptoms was a predictor of bad state resilience in PP (\u03b2=0.110, OR=1.117, p=0.028). No specific mental health outcome was associated with bad state resilience in UR and CC. Predictors of good state resilience in PP were having pursued hobbies/conducted home tasks (\u03b2=1.261, OR=3.528, p=0.044) and level of organization in the family (\u03b2=0.986, OR=2.682, p=0.008). Having a controlling family was inversely associated with good state resilience in CC (\u03b2=-1.004, OR=0.367, p=0.012). The association between bad state resilience and depressive symptoms was partially mediated by affective temperaments.\n\nParticipants self-reported their psychiatric diagnoses, their relatives' diagnoses or the absence of a psychiatric disorder, as well as their psychiatric symptoms.\n\nEnhancing resilience and coping strategies in the face of the COVID-19 pandemic might have important implications in terms of mental health outcomes.", "doi": "10.1016/j.jad.2021.01.055", "pmid": "33556749", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0165-0327(21)00072-0"}], "notes": [], "created": "2021-02-10T18:49:17.593Z", "modified": "2021-02-26T08:47:00.157Z"}, {"entity": "publication", "iuid": "44648b3c4cbd4654ac3ed76ef11c460b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44648b3c4cbd4654ac3ed76ef11c460b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44648b3c4cbd4654ac3ed76ef11c460b"}}, "title": "Epidemiological modeling in StochSS Live!", "authors": [{"family": "Jiang", "given": "Richard", "initials": "R"}, {"family": "Jacob", "given": "Bruno", "initials": "B"}, {"family": "Geiger", "given": "Matthew", "initials": "M"}, {"family": "Matthew", "given": "Sean", "initials": "S"}, {"family": "Rumsey", "given": "Bryan", "initials": "B"}, {"family": "Singh", "given": "Prashant", "initials": "P"}, {"family": "Wrede", "given": "Fredrik", "initials": "F"}, {"family": "Yi", "given": "Tau-Mu", "initials": "TM"}, {"family": "Drawert", "given": "Brian", "initials": "B"}, {"family": "Hellander", "given": "Andreas", "initials": "A"}, {"family": "Petzold", "given": "Linda", "initials": "L"}], "type": "journal article", "published": "2021-01-29", "journal": {"title": "Bioinformatics", "issn": "1367-4811", "volume": null, "issue": null, "issn-l": null}, "abstract": "We present StochSS Live!, a web-based service for modeling, simulation, and analysis of a wide range of mathematical, biological and biochemical systems. Using an epidemiological model of COVID-19, we demonstrate the power of StochSS Live! to enable researchers to quickly develop a deterministic or a discrete stochastic model, infer its parameters, and analyze the results.\n\nStochSS Live! is freely available at https://live.stochss.org/.\n\nAvailable at https://github.com/StochSS/Covid19_Modeling.", "doi": "10.1093/bioinformatics/btab061", "pmid": "33512399", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "6123781"}], "notes": [], "created": "2021-02-04T18:48:01.203Z", "modified": "2021-02-26T08:46:13.077Z"}, {"entity": "publication", "iuid": "2ff4fada5f5b4c6dbdc18860294d599a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ff4fada5f5b4c6dbdc18860294d599a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ff4fada5f5b4c6dbdc18860294d599a"}}, "title": "Clinical management of patients with genetic obesity during COVID-19 pandemic: position paper of the ESE Growth & Genetic Obesity COVID-19 Study Group and Rare Endo-ERN main thematic group on Growth and Obesity.", "authors": [{"family": "De Groot", "given": "Cornelis Jan", "initials": "CJ"}, {"family": "Poitou Bernert", "given": "Christine", "initials": "C"}, {"family": "Coupaye", "given": "Muriel", "initials": "M"}, {"family": "Clement", "given": "Karine", "initials": "K"}, {"family": "Paschou", "given": "Stavroula A", "initials": "SA"}, {"family": "Charmandari", "given": "Evangelia", "initials": "E"}, {"family": "Kanaka-Gantenbein", "given": "Christina", "initials": "C"}, {"family": "Wabitsch", "given": "Martin", "initials": "M"}, {"family": "Buddingh", "given": "Emilie P", "initials": "EP"}, {"family": "Nieuwenhuijsen", "given": "Barbara", "initials": "B"}, {"family": "Marina", "given": "Ljiljana", "initials": "L"}, {"family": "Johannsson", "given": "Gudmundur", "initials": "G"}, {"family": "Van Den Akker", "given": "E L T", "initials": "ELT"}], "type": "journal article", "published": "2021-01-29", "journal": {"title": "Endocrine", "issn": "1559-0100", "volume": null, "issue": null, "issn-l": "1355-008X"}, "abstract": "This article aims to provide guidance on prevention and treatment of COVID-19 in patients with genetic obesity. Key principals of the management of patients with genetic obesity during COVID-19 pandemic for patients that have contracted COVID-19 are to be aware of: possible adrenal insufficiency (e.g., POMC deficiency, PWS); a more severe course in patients with concomitant immunodeficiency (e.g., LEP and LEPR deficiency), although defective leptin signalling could also be protective against the pro-inflammatory phenotype of COVID-19; disease severity being masked by insufficient awareness of symptoms in syndromic obesity patients with intellectual deficit (in particular PWS); to adjust medication dose to increased body size, preferably use dosing in m2; the high risk of malnutrition in patients with Sars-Cov2 infection, even in case of obesity. Key principals of the obesity management during the pandemic are to strive for optimal obesity management and a healthy lifestyle within the possibilities of the regulations to prevent weight (re)gain and to address anxiety within consultations, since prevalence of anxiety for COVID-19 is underestimated.", "doi": "10.1007/s12020-021-02619-y", "pmid": "33512658", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s12020-021-02619-y"}], "notes": [], "created": "2021-02-01T14:17:49.638Z", "modified": "2021-02-04T18:46:35.437Z"}, {"entity": "publication", "iuid": "1dd7b99287a64aae82fbb66fa2f1ee64", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1dd7b99287a64aae82fbb66fa2f1ee64.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1dd7b99287a64aae82fbb66fa2f1ee64"}}, "title": "The angiotensin type 2 receptor agonist C21 restores respiratory function in COVID19 - a double-blind, randomized, placebo-controlled Phase 2 trial", "authors": [{"family": "Tornling", "given": "Goran", "initials": "G"}, {"family": "Batta", "given": "Rohit", "initials": "R"}, {"family": "Porter", "given": "Joanna", "initials": "J"}, {"family": "Bengtsson", "given": "Thomas", "initials": "T"}, {"family": "Parmar", "given": "Kartikeya", "initials": "K"}, {"family": "Kashiva", "given": "Reema", "initials": "R"}, {"family": "Cohrt", "given": "Anne Kartine", "initials": "AK"}, {"family": "Westergaard", "given": "Kate", "initials": "K"}, {"family": "Hallberg", "given": "Anders", "initials": "A"}, {"family": "Dalsgaard", "given": "Carl Johan", "initials": "CJ"}, {"family": "Raud", "given": "Johan", "initials": "J"}], "type": "posted-content", "published": "2021-01-28", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.01.26.21250511", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-01-29T17:30:36.012Z", "modified": "2021-04-14T04:54:19.107Z"}, {"entity": "publication", "iuid": "99f3ad7311d94bdfb953d113b4c13f07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/99f3ad7311d94bdfb953d113b4c13f07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/99f3ad7311d94bdfb953d113b4c13f07"}}, "title": "Prosociality predicts health behaviors during the COVID-19 pandemic.", "authors": [{"family": "Campos-Mercade", "given": "Pol", "initials": "P"}, {"family": "Meier", "given": "Armando N", "initials": "AN"}, {"family": "Schneider", "given": "Florian H", "initials": "FH"}, {"family": "Wengstr\u00f6m", "given": "Erik", "initials": "E"}], "type": "journal article", "published": "2021-01-28", "journal": {"title": "J Public Econ", "issn": "0047-2727", "issn-l": null, "volume": "195", "issue": null, "pages": "104367"}, "abstract": "Socially responsible behavior is crucial for slowing the spread of infectious diseases. However, economic and epidemiological models of disease transmission abstract from prosocial motivations as a driver of behaviors that impact the health of others. In an incentivized study, we show that a large majority of people are very reluctant to put others at risk for their personal benefit. Moreover, this experimental measure of prosociality predicts health behaviors during the COVID-19 pandemic, measured in a separate and ostensibly unrelated study with the same people. Prosocial individuals are more likely to follow physical distancing guidelines, stay home when sick, and buy face masks. We also find that prosociality measured two years before the pandemic predicts health behaviors during the pandemic. Our findings indicate that prosociality is a stable, long-term predictor of policy-relevant behaviors, suggesting that the impact of policies on a population may depend on the degree of prosociality.", "doi": "10.1016/j.jpubeco.2021.104367", "pmid": "33531719", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0047-2727(21)00003-7"}, {"db": "pmc", "key": "PMC7842154"}], "notes": [], "created": "2021-02-04T18:15:49.542Z", "modified": "2021-06-18T11:18:04.011Z"}, {"entity": "publication", "iuid": "6a6cc2301530439993435a8e3a9ee021", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a6cc2301530439993435a8e3a9ee021.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a6cc2301530439993435a8e3a9ee021"}}, "title": "International collaboration and covid-19: what are we doing and where are we going?", "authors": [{"family": "Bump", "given": "Jesse B", "initials": "JB"}, {"family": "Friberg", "given": "Peter", "initials": "P"}, {"family": "Harper", "given": "David R", "initials": "DR"}], "type": "journal-article", "published": "2021-01-28", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "372", "issue": null, "pages": "n180", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.n180", "pmid": "33509953", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-29T15:09:32.995Z", "modified": "2021-02-04T18:50:16.483Z"}, {"entity": "publication", "iuid": "66069e285b254e06ab7fc0f3d4e4539a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66069e285b254e06ab7fc0f3d4e4539a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66069e285b254e06ab7fc0f3d4e4539a"}}, "title": "Functional myeloid-derived suppressor cells expand in blood but not airways of COVID-19 patients and predict disease severity", "authors": [{"family": "Falck-Jones", "given": "Sara", "initials": "S"}, {"family": "Vangeti", "given": "Sindhu", "initials": "S"}, {"family": "Yu", "given": "Meng", "initials": "M"}, {"family": "Falck-Jones", "given": "Ryan", "initials": "R"}, {"family": "Cagigi", "given": "Alberto", "initials": "A"}, {"family": "Badolati", "given": "Isabella", "initials": "I"}, {"family": "Osterberg", "given": "Bjorn", "initials": "B"}, {"family": "Lautenbach", "given": "Maximilian Julius", "initials": "MJ"}, {"family": "Ahlberg", "given": "Eric", "initials": "E"}, {"family": "Lin", "given": "Ang", "initials": "A"}, {"family": "Szurgot", "given": "Inga", "initials": "I"}, {"family": "Lenart", "given": "Klara", "initials": "K"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Salde", "given": "Jorgen", "initials": "J"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "Lore", "given": "Karin", "initials": "K"}, {"family": "Farnert", "given": "Anna", "initials": "A"}, {"family": "Smed-Sorensen", "given": "Anna", "initials": "A"}], "type": "posted-content", "published": "2021-01-28", "journal": {"title": "J Clin Invest", "issn": "1558-8238", "issn-l": null, "volume": "131", "issue": "6", "pages": null}, "abstract": "The immunopathology of COVID-19 remains enigmatic, exhibiting immunodysregulation and T cell lymphopenia. Monocytic myeloid-derived suppressor cells (M-MDSC) are T cell suppressors that expand in inflammatory conditions, but their role in acute respiratory infections remains unclear. We studied blood and airways of COVID-19 patients across disease severity at multiple timepoints. M-MDSC frequencies were elevated in blood but not in nasopharyngeal or endotracheal aspirates of COVID-19 patients compared to controls. M-MDSCs isolated from COVID-19 patients suppressed T cell proliferation and IFN\u03b3 production partly via an arginase-1 (Arg-1) dependent mechanism. Furthermore, patients showed increased Arg-1 and IL-6 plasma levels. COVID-19 patients had fewer T cells, and displayed downregulated expression of the CD3\u03b6 chain. Ordinal regression showed that early M-MDSC frequency predicted subsequent disease severity. In conclusion, M-MDSCs expand in blood of COVID-19 patients, suppress T cells and strongly associate with disease severity, suggesting a role for M-MDSCs in the dysregulated COVID-19 immune response.", "doi": "10.1172/JCI144734", "pmid": "33492309", "labels": {"Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Research Area: High-throughput and high-content serology": null, "Type: Journal article": null, "Category: Health": null, "Category: Proteins": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-10-30T11:28:02.561Z", "modified": "2021-06-11T14:27:07.830Z"}, {"entity": "publication", "iuid": "ea8fff00c253452595ddbecf13dfa262", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ea8fff00c253452595ddbecf13dfa262.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ea8fff00c253452595ddbecf13dfa262"}}, "title": "Covid-19\u2014a rehearsal to build a greener and healthier society", "authors": [{"family": "Nilsson", "given": "Maria", "initials": "M"}, {"family": "Ebi", "given": "Kristie L", "initials": "KL"}, {"family": "Campbell-Lendrum", "given": "Diarmid", "initials": "D"}, {"family": "Kone", "given": "Brama", "initials": "B"}, {"family": "Friberg", "given": "Peter", "initials": "P"}], "type": "journal-article", "published": "2021-01-28", "journal": {"title": "BMJ", "issn": "1756-1833", "issn-l": null, "volume": "372", "issue": null, "pages": "n127"}, "abstract": null, "doi": "10.1136/bmj.n127", "pmid": "33509800", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-01-29T15:10:48.019Z", "modified": "2022-11-23T09:03:00.846Z"}, {"entity": "publication", "iuid": "239215138eaa431c808a711ca70c705f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/239215138eaa431c808a711ca70c705f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/239215138eaa431c808a711ca70c705f"}}, "title": "Collaborative platform trials to fight COVID-19: methodological and regulatory considerations for a better societal outcome.", "authors": [{"family": "Collignon", "given": "Olivier", "initials": "O"}, {"family": "Burman", "given": "Carl-Fredrik", "initials": "C"}, {"family": "Posch", "given": "Martin", "initials": "M"}, {"family": "Schiel", "given": "Anja", "initials": "A"}], "type": "journal article", "published": "2021-01-28", "journal": {"title": "Clin Pharmacol Ther", "issn": "1532-6535", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "For the development of COVID-19 drugs during the ongoing pandemic, speed is of essence while quality of evidence is of paramount importance. While thousands of COVID-19 trials were rapidly started, many are unlikely to provide robust statistical evidence and meet regulatory standards, e.g. because of lack of randomisation or insufficient power. This has led to an inefficient use of time and resources. With more coordination, the sheer number of patients in these trials might have generated convincing data for several investigational treatments. Collaborative platform trials, comparing several drugs to a shared control arm, are an attractive solution. Those trials can utilise a variety of adaptive design features in order to accelerate the finding of life-saving treatments. In this manuscript we discuss several possible designs, illustrate them via simulations and also discuss challenges, such as the heterogeneity of the target population, time-varying standard of care, and the potentially high number of false hypothesis rejections in Phase 2 and Phase 3. We provide corresponding regulatory perspectives on approval and reimbursement, and note that the optimal design of a platform trial will differ with our societal objective and by stakeholder. Hasty approvals may delay the development of better alternatives, while searching relentlessly for the single most efficacious treatment may indirectly diminish the number of lives saved as time is lost. We point out the need for incentivising developers to participate in collaborative evidence-generation initiatives when a positive return on investment is not met.", "doi": "10.1002/cpt.2183", "pmid": "33506495", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2021-01-29T15:13:01.950Z", "modified": "2021-02-04T19:05:39.855Z"}, {"entity": "publication", "iuid": "8f4a1e192b2b45d2b8217e2dfc0de36e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f4a1e192b2b45d2b8217e2dfc0de36e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f4a1e192b2b45d2b8217e2dfc0de36e"}}, "title": "To stress or not to stress: Brain-behavior-immune interaction may weaken or promote the immune response to SARS-CoV-2.", "authors": [{"family": "Peters", "given": "Eva M J", "initials": "EMJ"}, {"family": "Schedlowski", "given": "Manfred", "initials": "M"}, {"family": "Watzl", "given": "Carsten", "initials": "C"}, {"family": "Gimsa", "given": "Ulrike", "initials": "U"}], "type": "journal article", "published": "2021-01-27", "journal": {"title": "Neurobiol Stress", "issn": "2352-2895", "issn-l": null, "volume": "14", "issue": null, "pages": "100296"}, "abstract": "The COVID-19 pandemic continues to strongly affect people with health disadvantages, creating a heavy burden on medical systems and societies worldwide. Research is growing rapidly and recently revealed that stress-related factors such as socio-economic status, may also play a pivotal role. However, stress research investigating the underlying psychoneuroimmune interactions is missing. Here we address the question whether stress-associated neuroendocrine-immune mechanisms can possibly contribute to an increase in SARS-CoV-2 infections and influence the course of COVID-19 disease. Additionally, we discuss that not all forms of stress (e.g. acute versus chronic) are detrimental and that some types of stress could attenuate infection-risk and -progression. The overall aim of this review is to motivate future research efforts to clarify whether psychosocial interventions have the potential to optimize neuroendocrine-immune responses against respiratory viral infections during and beyond the COVID-19 pandemic. The current state of research on different types of stress is summarized in a comprehensive narrative review to promote a psychoneuroimmune understanding of how stress and its mediators cortisol, (nor)adrenaline, neuropeptides and neurotrophins can shape the immune defense against viral diseases. Based on this understanding, we describe how people with high psychosocial stress can be identified, which behaviors and psychosocial interventions may contribute to optimal stress management, and how psychoneuroimmune knowledge can be used to improve adequate care for COVID-19 and other patients with viral infections.", "doi": "10.1016/j.ynstr.2021.100296", "pmid": "33527083", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2352-2895(21)00004-7"}, {"db": "pmc", "key": "PMC7839386"}], "notes": [], "created": "2021-02-04T18:18:58.208Z", "modified": "2021-06-18T11:16:45.923Z"}, {"entity": "publication", "iuid": "a07ce6c124df46ce8d299b82d7921c13", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a07ce6c124df46ce8d299b82d7921c13.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a07ce6c124df46ce8d299b82d7921c13"}}, "title": "Mental Health Consequences for Healthcare Workers During the COVID-19 Pandemic: A Scoping Review to Draw Lessons for LMICs.", "authors": [{"family": "Moitra", "given": "Modhurima", "initials": "M"}, {"family": "Rahman", "given": "Muhammad", "initials": "M"}, {"family": "Collins", "given": "Pamela Y", "initials": "PY"}, {"family": "Gohar", "given": "Fatima", "initials": "F"}, {"family": "Weaver", "given": "Marcia", "initials": "M"}, {"family": "Kinuthia", "given": "John", "initials": "J"}, {"family": "R\u00f6ssler", "given": "Wulf", "initials": "W"}, {"family": "Petersen", "given": "Stefan", "initials": "S"}, {"family": "Unutzer", "given": "Jurgen", "initials": "J"}, {"family": "Saxena", "given": "Shekhar", "initials": "S"}, {"family": "Huang", "given": "Keng Yen", "initials": "KY"}, {"family": "Lai", "given": "Joanna", "initials": "J"}, {"family": "Kumar", "given": "Manasi", "initials": "M"}], "type": "journal article", "published": "2021-01-27", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "12", "issue": null, "pages": "602614", "issn-l": "1664-0640"}, "abstract": "Background: The COVID-19 pandemic has had a significant impact on the mental health of healthcare workers (HCWs) particularly in low and middle-income countries (LMICs). This scoping review provides a summary of current evidence on the mental health consequences of COVID on HCWs. Methods: A scoping review was conducted searching PubMed and Embase for articles relevant to mental health conditions among HCWs during COVID-19. Relevant articles were screened and extracted to summarize key outcomes and findings. Results: A total of fifty-one studies were included in this review. Depressive symptoms, anxiety symptoms, psychological trauma, insomnia and sleep quality, workplace burnout and fatigue, and distress were the main outcomes reviewed. Most studies found a high number of symptoms endorsed for depression, anxiety, and other conditions. We found differences in symptoms by sex, age, and HCW role, with female, younger-aged, frontline workers, and non-physician workers being affected more than other subgroups. Conclusion: This review highlights the existing burden of mental health conditions reported by HCWs during COVID-19. It also demonstrates emerging disparities among affected HCW subgroups. This scoping review emphasizes the importance of generating high quality evidence and developing informed interventions for HCW mental health with a focus on LMICs.", "doi": "10.3389/fpsyt.2021.602614", "pmid": "33584383", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7873361"}], "notes": [], "created": "2021-02-17T14:47:10.441Z", "modified": "2021-02-26T08:47:00.126Z"}, {"entity": "publication", "iuid": "5639168d872f41ad8a36f99059c0cd8a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5639168d872f41ad8a36f99059c0cd8a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5639168d872f41ad8a36f99059c0cd8a"}}, "title": "Lung Ultrasound for Identification of Patients Requiring Invasive Mechanical Ventilation in COVID-19.", "authors": [{"family": "Seiler", "given": "Claudia", "initials": "C"}, {"family": "Klingberg", "given": "Cecilia", "initials": "C"}, {"family": "H\u00e5rdstedt", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-01-26", "journal": {"title": "J Ultrasound Med", "issn": "1550-9613", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Indication for invasive mechanical ventilation in COVID-19 pneumonia has been a major challenge. This study aimed to evaluate if lung ultrasound (LUS) can assist identification of requirement of invasive mechanical ventilation in moderate to severe COVID-19 pneumonia.\r\n\r\nBetween April 23 and November 12, 2020, hospitalized patients with moderate to severe COVID-19 (oxygen demand \u22654 L/min) were included consecutively. Lung ultrasound was performed daily until invasive mechanical ventilation (IMV-group) or spontaneous recovery (non-IMV-group). Clinical parameters and lung ultrasound findings were compared between groups, at intubation (IMV-group) and highest oxygen demand (non-IMV-group). A reference group with oxygen demand <4 L/min was examined at hospital admission.\r\n\r\nAltogether 72 patients were included: 50 study patients (IMV-group, n = 23; non-IMV-group, n = 27) and 22 reference patients. LUS-score correlated to oxygen demand (SpO 2 /FiO2 -ratio) (r = 0.728; p < 0.0001) and was higher in the IMV-group compared to the non-IMV-group (20.0 versus 18.0; p = 0.026). Based on receiver operating characteristic analysis, a LUS-score of 19.5 was identified as cut-off for requirement of invasive mechanical ventilation (area under the curve 0.68; sensitivity 56%, specificity 74%). In 6 patients, LUS identified critical coexisting conditions. Respiratory rate and oxygenation index ((SpO2 /FiO2 )/respiratory rate) \u22654.88 identified no requirement of invasive mechanical ventilation with a positive predictive value of 87% and negative predictive value of 100%.\r\n\r\nLUS-score had only a moderate diagnostic value for requirement of invasive mechanical ventilation in moderate to severe COVID-19. However, LUS proved valuable as complement to respiratory parameters in guidance of disease severity and identifying critical coexisting conditions.", "doi": "10.1002/jum.15617", "pmid": "33496362", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-29T15:37:32.985Z", "modified": "2021-06-18T11:03:00.455Z"}, {"entity": "publication", "iuid": "8a7a467b9af54956b811e2c8c056c6fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a7a467b9af54956b811e2c8c056c6fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a7a467b9af54956b811e2c8c056c6fd"}}, "title": "Community Participation Approaches for Effective National COVID-19 Pandemic Preparedness and Response: An Experience From Oman.", "authors": [{"family": "Al Siyabi", "given": "Huda", "initials": "H"}, {"family": "Al Mukhaini", "given": "Said", "initials": "S"}, {"family": "Kanaan", "given": "Mohsen", "initials": "M"}, {"family": "Al Hatmi", "given": "Sumaya", "initials": "S"}, {"family": "Al Anqoudi", "given": "Zahir", "initials": "Z"}, {"family": "Al Kalbani", "given": "Ahmed", "initials": "A"}, {"family": "Al Bahri", "given": "Zakiya", "initials": "Z"}, {"family": "Wannous", "given": "Chadia", "initials": "C"}, {"family": "Al Awaidy", "given": "Salah T", "initials": "ST"}], "type": "journal article", "published": "2021-01-26", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "616763", "issn-l": "2296-2565"}, "abstract": "Oman, like other countries in the world, was affected by the COVID-19 pandemic. Since the WHO's declaration of the pandemic, the Ministry of Health of Oman has initiated its preparedness and response to the pandemic, with community participation as one of the key components of the national preparedness and response plan. This paper is a descriptive study aims at describing the three community approaches that exist in Oman and reviewing their role in preparedness and response strategies to COVID-19 pandemic and discuss the lessons learned. Community participation approaches in Oman were translated into action during the pandemic through empowering community members, mobilizing resources, and strengthening the ownership among the local community to ensure effective advocacy, proper networking, and dissemination of information and, subsequently, actions at the level of the community. The first community participation approach is community organizations within the healthy cities and villages initiative, which facilitated networking and acted as a platform for community engagement, reviewing the health information and updating them accordingly to meet evloving demands. The second approach is Willayat (District) health committees, with their unique multi-sectoral structure, that enhanced collaboration at the state level with different community leaders and groups to develop pandemic action plans, which were implemented using available local resources. The third approach is community volunteers that remain the key information providers, particularly when physical access becomes limited due to physical distancing measures. Based on this review, we advocate to further strengthen these approaches and recommends that they are implemented for the protection and promotion of health and well-being, including for health emergencies.", "doi": "10.3389/fpubh.2020.616763", "pmid": "33575243", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7870984"}], "notes": [], "created": "2021-02-15T12:53:28.419Z", "modified": "2021-02-26T08:47:00.041Z"}, {"entity": "publication", "iuid": "a3ae0299260c4571aa064bee1cca91e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3ae0299260c4571aa064bee1cca91e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3ae0299260c4571aa064bee1cca91e8"}}, "title": "Anthropogenic Infection of Cats during the 2020 COVID-19 Pandemic.", "authors": [{"family": "Hosie", "given": "Margaret J", "initials": "MJ", "orcid": "0000-0002-4313-5023", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f40c8d7a2904c3b8fde7546efa3935f.json"}}, {"family": "Hofmann-Lehmann", "given": "Regina", "initials": "R", "orcid": "0000-0001-9750-4296", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d5e8b0620f9b4c208af59a06749465c2.json"}}, {"family": "Hartmann", "given": "Katrin", "initials": "K"}, {"family": "Egberink", "given": "Herman", "initials": "H", "orcid": "0000-0001-6852-5936", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab5a969ee05c459cad512e7da7eb80b2.json"}}, {"family": "Truyen", "given": "Uwe", "initials": "U"}, {"family": "Addie", "given": "Diane D", "initials": "DD", "orcid": "0000-0001-7843-2661", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b7c3e3dfc64a47758df348a154925228.json"}}, {"family": "Bel\u00e1k", "given": "S\u00e1ndor", "initials": "S"}, {"family": "Boucraut-Baralon", "given": "Corine", "initials": "C", "orcid": "0000-0002-6033-450X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/55399dde51584fb2ac0878ca1581a6c1.json"}}, {"family": "Frymus", "given": "Tadeusz", "initials": "T", "orcid": "0000-0002-9160-1455", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aee4488d842149ff9fec4d44f5bf4e21.json"}}, {"family": "Lloret", "given": "Albert", "initials": "A"}, {"family": "Lutz", "given": "Hans", "initials": "H"}, {"family": "Marsilio", "given": "Fulvio", "initials": "F", "orcid": "0000-0001-9552-1199", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc7ae4bb1210413589a00714602bed79.json"}}, {"family": "Pennisi", "given": "Maria Grazia", "initials": "MG"}, {"family": "Tasker", "given": "S\u00e9verine", "initials": "S", "orcid": "0000-0002-4059-1402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25cba4cd2417458e9d74ff2ba1d10f5b.json"}}, {"family": "Thiry", "given": "Etienne", "initials": "E"}, {"family": "M\u00f6stl", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2021-01-26", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "2", "issn-l": "1999-4915"}, "abstract": "COVID-19 is a severe acute respiratory syndrome (SARS) caused by a new coronavirus (CoV), SARS-CoV-2, which is closely related to SARS-CoV that jumped the animal-human species barrier and caused a disease outbreak in 2003. SARS-CoV-2 is a betacoronavirus that was first described in 2019, unrelated to the commonly occurring feline coronavirus (FCoV) that is an alphacoronavirus associated with feline infectious peritonitis (FIP). SARS-CoV-2 is highly contagious and has spread globally within a few months, resulting in the current pandemic. Felids have been shown to be susceptible to SARS-CoV-2 infection. Particularly in the Western world, many people live in very close contact with their pet cats, and natural infections of cats in COVID-19-positive households have been described in several countries. In this review, the European Advisory Board on Cat Diseases (ABCD), a scientifically independent board of experts in feline medicine from 11 European Countries, discusses the current status of SARS-CoV infections in cats. The review examines the host range of SARS-CoV-2 and human-to-animal transmissions, including infections in domestic and non-domestic felids, as well as mink-to-human/-cat transmission. It summarises current data on SARS-CoV-2 prevalence in domestic cats and the results of experimental infections of cats and provides expert opinions on the clinical relevance and prevention of SARS-CoV-2 infection in cats.", "doi": "10.3390/v13020185", "pmid": "33530620", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7911697"}, {"db": "pii", "key": "v13020185"}], "notes": [], "created": "2021-02-04T18:19:42.314Z", "modified": "2023-01-13T13:36:31.494Z"}, {"entity": "publication", "iuid": "30c58c30456d4cd5ba9b9340b1837eba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/30c58c30456d4cd5ba9b9340b1837eba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/30c58c30456d4cd5ba9b9340b1837eba"}}, "title": "Severe acute kidney injury associated with progression of chronic kidney disease after critical COVID-19.", "authors": [{"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Wallin", "given": "Ewa", "initials": "E"}, {"family": "Larsson", "given": "Ing-Marie", "initials": "I"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2021-01-25", "journal": {"title": "Crit Care", "issn": "1466-609X", "issn-l": "1364-8535", "volume": "25", "issue": "1", "pages": "37"}, "abstract": null, "doi": "10.1186/s13054-021-03461-4", "pmid": "33494766", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-021-03461-4"}, {"db": "ClinicalTrials.gov", "key": "NCT04474249", "description": null}], "notes": [], "created": "2021-01-28T06:54:06.133Z", "modified": "2021-06-14T14:34:29.920Z"}, {"entity": "publication", "iuid": "46ccb5a0c1e04a72b1005a9538a1ab25", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46ccb5a0c1e04a72b1005a9538a1ab25.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46ccb5a0c1e04a72b1005a9538a1ab25"}}, "title": "Elucidating the Interactions Between Heparin/Heparan Sulfate and SARS-CoV-2-Related Proteins-An Important Strategy for Developing Novel Therapeutics for the COVID-19 Pandemic.", "authors": [{"family": "Yu", "given": "Mingjia", "initials": "M"}, {"family": "Zhang", "given": "Tianji", "initials": "T"}, {"family": "Zhang", "given": "Wei", "initials": "W"}, {"family": "Sun", "given": "Qianyun", "initials": "Q"}, {"family": "Li", "given": "Hongmei", "initials": "H"}, {"family": "Li", "given": "Jin-Ping", "initials": "JP"}], "type": "journal article", "published": "2021-01-25", "journal": {"title": "Front. Mol. Biosci.", "issn": "2296-889X", "volume": "7", "issue": null, "pages": "628551", "issn-l": null}, "abstract": "Owing to the high mortality and the spread rate, the infectious disease caused by SARS-CoV-2 has become a major threat to public health and social economy, leading to over 70 million infections and 1. 6 million deaths to date. Since there are currently no effective therapeutic or widely available vaccines, it is of urgent need to look for new strategies for the treatment of SARS-CoV-2 infection diseases. Binding of a viral protein onto cell surface heparan sulfate (HS) is generally the first step in a cascade of interaction that is required for viral entry and the initiation of infection. Meanwhile, interactions of selectins and cytokines (e.g., IL-6 and TNF-\u03b1) with HS expressed on endothelial cells are crucial in controlling the recruitment of immune cells during inflammation. Thus, structurally defined heparin/HS and their mimetics might serve as potential drugs by competing with cell surface HS for the prevention of viral adhesion and modulation of inflammatory reaction. In this review, we will elaborate coronavirus invasion mechanisms and summarize the latest advances in HS-protein interactions, especially proteins relevant to the process of coronavirus infection and subsequent inflammation. Experimental and computational techniques involved will be emphasized.", "doi": "10.3389/fmolb.2020.628551", "pmid": "33569392", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7868326"}], "notes": [], "created": "2021-02-11T15:22:24.203Z", "modified": "2021-07-14T07:52:18.779Z"}, {"entity": "publication", "iuid": "c2ecaa70043f4c2dba8b717f582fc41d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2ecaa70043f4c2dba8b717f582fc41d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2ecaa70043f4c2dba8b717f582fc41d"}}, "title": "Bispecific antibody neutralizes circulating SARS-CoV-2 variants, prevents escape and protects mice from disease", "authors": [{"family": "De Gasparo", "given": "Raoul", "initials": "R"}, {"family": "Pedotti", "given": "Mattia", "initials": "M"}, {"family": "Simonelli", "given": "Luca", "initials": "L"}, {"family": "Nickl", "given": "Petr", "initials": "P"}, {"family": "Muecksch", "given": "Frauke", "initials": "F"}, {"family": "Cassaniti", "given": "Irene", "initials": "I"}, {"family": "Percivalle", "given": "Elena", "initials": "E"}, {"family": "Lorenzi", "given": "Julio C C", "initials": "JCC"}, {"family": "Mazzola", "given": "Federica", "initials": "F"}, {"family": "Magr\u00ec", "given": "Davide", "initials": "D"}, {"family": "Michalcikova", "given": "Tereza", "initials": "T"}, {"family": "Haviernik", "given": "Jan", "initials": "J"}, {"family": "Honig", "given": "Vaclav", "initials": "V"}, {"family": "Mrazkova", "given": "Blanka", "initials": "B"}, {"family": "Polakova", "given": "Natalie", "initials": "N"}, {"family": "Fortova", "given": "Andrea", "initials": "A"}, {"family": "Tureckova", "given": "Jolana", "initials": "J"}, {"family": "Iatsiuk", "given": "Veronika", "initials": "V"}, {"family": "Girolamo", "given": "Salvatore Di", "initials": "SD"}, {"family": "Palus", "given": "Martin", "initials": "M"}, {"family": "Zudova", "given": "Dagmar", "initials": "D"}, {"family": "Bednar", "given": "Petr", "initials": "P"}, {"family": "Bukova", "given": "Ivana", "initials": "I"}, {"family": "Bianchini", "given": "Filippo", "initials": "F"}, {"family": "Mehn", "given": "Dora", "initials": "D"}, {"family": "Nencka", "given": "Radim", "initials": "R"}, {"family": "Strakova", "given": "Petra", "initials": "P"}, {"family": "Pavlis", "given": "Oto", "initials": "O"}, {"family": "Rozman", "given": "Jan", "initials": "J"}, {"family": "Gioria", "given": "Sabrina", "initials": "S"}, {"family": "Camilla Sammartino", "given": "Jos\u00e8", "initials": "J"}, {"family": "Giardina", "given": "Federica", "initials": "F"}, {"family": "Gaiarsa", "given": "Stefano", "initials": "S"}, {"family": "Hammarstr\u00f6m", "given": "Qiang Pan", "initials": "QP"}, {"family": "Barnes", "given": "Christopher O", "initials": "CO"}, {"family": "Bjorkman", "given": "Pamela J", "initials": "PJ"}, {"family": "Calzolai", "given": "Luigi", "initials": "L"}, {"family": "Piralla", "given": "Antonio", "initials": "A"}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Nussenzweig", "given": "Michel C", "initials": "MC"}, {"family": "Bieniasz", "given": "Paul D", "initials": "PD"}, {"family": "Hatziioannou", "given": "Theodora", "initials": "T"}, {"family": "Prochazka", "given": "Jan", "initials": "J"}, {"family": "Sedlacek", "given": "Radislav", "initials": "R"}, {"family": "Robbiani", "given": "Davide F", "initials": "DF"}, {"family": "Ruzek", "given": "Daniel", "initials": "D"}, {"family": "Varani", "given": "Luca", "initials": "L"}], "type": "posted-content", "published": "2021-01-22", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.01.22.427567", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Proteins": null}, "xrefs": [], "notes": [], "created": "2021-06-10T03:58:04.158Z", "modified": "2021-06-10T03:58:32.998Z"}, {"entity": "publication", "iuid": "1becbf8709b94abc8098d4683f2bc703", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1becbf8709b94abc8098d4683f2bc703.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1becbf8709b94abc8098d4683f2bc703"}}, "title": "Pride and Uncertainty: A Qualitative Study of Danish Nursing Staff in Temporary COVID-19 Wards.", "authors": [{"family": "Marsaa", "given": "Kristoffer", "initials": "K"}, {"family": "Mendahl", "given": "Janni", "initials": "J"}, {"family": "Heilman", "given": "Henriette", "initials": "H"}, {"family": "Johansson", "given": "H\u00e9l\u00e8ne", "initials": "H"}, {"family": "Husum", "given": "Mette", "initials": "M"}, {"family": "Lippert", "given": "Dorthe", "initials": "D"}, {"family": "Sandholm", "given": "Niels", "initials": "N"}, {"family": "Konradsen", "given": "Hanne", "initials": "H"}], "type": "journal article", "published": "2021-01-21", "journal": {"title": "J Hosp Palliat Nurs", "issn": "1539-0705", "volume": "Publish Ahead of Print", "issue": null, "issn-l": null}, "abstract": "There is limited knowledge about the psychosocial stress among the nursing staff working on the COVID-19 wards. This article reports on the experiences of frontline health care workers as it was described to supervisors counseling the nursing staff engaged in the response to the outbreak of COVID-19. Frontline health care workers, nurses, and nurses' aides experienced major work changes. Some were transferred to the newly formed COVID-19 wards in a large Danish hospital, were given new tasks, and had to collaborate with new colleagues, while treating a new deadly and contagious disease. This study aimed to describe the reflections and experiences of the nursing staff attending supervision sessions. The palliative unit offered supervision from April 2020. A total of 9 supervision sessions were held as part of this study, and 57 nursing staff members participated in the sessions. The supervision was available to employees until the first COVID wave subsided in June 2020. During each session, supervisors took field notes and wrote field memos. The topics raised by the nursing staff during the supervision sessions ranged between pride and uncertainty. Nursing staff in COVID-19 wards were at risk of feeling an increasing burden, and there was a need for ongoing managerial attention as well as continuous visible presence and support.", "doi": "10.1097/NJH.0000000000000722", "pmid": "33496527", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "00129191-900000000-99827"}], "notes": [], "created": "2021-01-29T15:27:44.122Z", "modified": "2021-02-26T08:46:59.850Z"}, {"entity": "publication", "iuid": "6f88214beb5042b4a692919478f76efe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f88214beb5042b4a692919478f76efe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f88214beb5042b4a692919478f76efe"}}, "title": "Detection of SARS-CoV-2 using non-commercial RT-LAMP regents and raw samples.", "authors": [{"family": "Alekseenko", "given": "Alisa", "initials": "A"}, {"family": "Barrett", "given": "Donal", "initials": "D"}, {"family": "Pareja-Sanchez", "given": "Yerma", "initials": "Y"}, {"family": "Howard", "given": "Rebecca", "initials": "R"}, {"family": "Strandback", "given": "Emilia", "initials": "E"}, {"family": "Ampah-Korsah", "given": "Henry", "initials": "H"}, {"family": "Rov\u0161nik", "given": "Ur\u0161ka", "initials": "U"}, {"family": "Zuniga-Veliz", "given": "Silvia", "initials": "S"}, {"family": "Klenov", "given": "Alexander", "initials": "A"}, {"family": "Malloo", "given": "Jayshna", "initials": "J"}, {"family": "Ye", "given": "Shenglong", "initials": "S"}, {"family": "Liu", "given": "Xiyang", "initials": "X"}, {"family": "Reinius", "given": "B\u00f6jrn", "initials": "B"}, {"family": "Els\u00e4sser", "given": "Simon", "initials": "S"}, {"family": "Nyman", "given": "Tomas", "initials": "T"}, {"family": "Sandh", "given": "Gustaf", "initials": "G"}, {"family": "Yin", "given": "Xiushan", "initials": "X"}, {"family": "Pelechano", "given": "Vicent", "initials": "V"}], "type": "posted-content", "published": "2021-01-21", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "11", "issue": "1", "pages": "1820"}, "abstract": "RT-LAMP detection of SARS-CoV-2 has been shown as a valuable approach to scale up COVID-19 diagnostics and thus contribute to limiting the spread of the disease. Here we present the optimization of highly cost-effective in-house produced enzymes, and we benchmark their performance against commercial alternatives. We explore the compatibility between multiple DNA polymerases with high strand-displacement activity and thermostable reverse transcriptases required for RT-LAMP. We optimize reaction conditions and demonstrate their applicability using both synthetic RNA and clinical patient samples. Finally, we validated the optimized RT-LAMP assay for the detection of SARS-CoV-2 in raw nasopharyngeal samples from 184 patients. We anticipate that optimized and affordable reagents for RT-LAMP will facilitate the expansion of SARS-CoV-2 testing globally, especially in sites and settings with limited economic resources.", "doi": "10.1038/s41598-020-80352-8", "pmid": "33469065", "labels": {"Research Area: Diagnostics for virus": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Viral sequence evolution": null, "Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "URL", "key": "https://static-content.springer.com/esm/art%3A10.1038%2Fs41598-020-80352-8/MediaObjects/41598_2020_80352_MOESM3_ESM.xlsx", "description": "Numeric raw data for the amplifcation curves"}, {"db": "URL", "key": "https://static-content.springer.com/esm/art%3A10.1038%2Fs41598-020-80352-8/MediaObjects/41598_2020_80352_MOESM2_ESM.xlsx", "description": "Ct values for clinical samples from GeneXpert and all the RT-LAMP trials"}], "notes": [], "created": "2020-11-11T06:52:33.154Z", "modified": "2021-06-14T14:34:14.486Z"}, {"entity": "publication", "iuid": "91395e0a12e940bf8b5195ae8a6bcf76", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/91395e0a12e940bf8b5195ae8a6bcf76.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/91395e0a12e940bf8b5195ae8a6bcf76"}}, "title": "Should neurosurgeons continue to work in the absence of personal protective equipment during the COVID-19 era?", "authors": [{"family": "Eijkholt", "given": "Marleen", "initials": "M"}, {"family": "Hulsbergen", "given": "Alexander", "initials": "A"}, {"family": "Muskens", "given": "Ivo", "initials": "I"}, {"family": "Mathiesen", "given": "Tiit Illimar", "initials": "TI"}, {"family": "Bolger", "given": "Ciaran", "initials": "C"}, {"family": "Feldman", "given": "Zeev", "initials": "Z"}, {"family": "Kitchen", "given": "Neil", "initials": "N"}, {"family": "Sampr\u00f3n", "given": "Nicol\u00e1s", "initials": "N"}, {"family": "Sandvik", "given": "Ulrika", "initials": "U"}, {"family": "Tisell", "given": "Magnus", "initials": "M"}, {"family": "Broekman", "given": "Marike", "initials": "M"}], "type": "journal article", "published": "2021-01-20", "journal": {"title": "Acta Neurochir (Wien)", "issn": "0942-0940", "volume": null, "issue": null, "issn-l": "0001-6268"}, "abstract": "The COVID-19 pandemic has resulted in a widespread shortage of personal protective equipment (PPE). Many healthcare workers, including neurosurgeons, have expressed concern about how to safely and adequately perform their medical responsibilities in these challenging circumstances. One of these concerns revolves around the pressing question: should providers continue to work in the absence of adequate PPE? Although the first peak of the COVID-19 crisis seems to have subsided and supply of PPE has increased, concerns about insufficient PPE availability remain. Inconsistent supply, limited efficacy, and continued high demand for PPE, combined with the continued threat of a second COVID-19 wave, mean that the issues surrounding PPE availability remain unresolved, including a duty to work. This paper offers an ethical investigation of whether neurosurgeons should perform their professional responsibilities with limited availability of PPE. We evaluate ethical considerations and conflicting duties and thereby hope to facilitate providers in making a well-considered personal and moral decision about this challenging issue.", "doi": "10.1007/s00701-021-04703-8", "pmid": "33469692", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00701-021-04703-8"}], "notes": [], "created": "2021-01-22T09:12:54.748Z", "modified": "2021-01-22T09:12:54.812Z"}, {"entity": "publication", "iuid": "ac9d5631d7314b86854499c85db583c3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac9d5631d7314b86854499c85db583c3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac9d5631d7314b86854499c85db583c3"}}, "title": "Psychometric Properties of the Norwegian Version of the Fear of COVID-19 Scale.", "authors": [{"family": "Iversen", "given": "M M", "initials": "MM"}, {"family": "Norekv\u00e5l", "given": "T M", "initials": "TM"}, {"family": "Oterhals", "given": "K", "initials": "K"}, {"family": "Fadnes", "given": "L T", "initials": "LT"}, {"family": "M\u00e6land", "given": "S", "initials": "S"}, {"family": "Pakpour", "given": "A H", "initials": "AH"}, {"family": "Breivik", "given": "K", "initials": "K"}], "type": "journal article", "published": "2021-01-20", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "issn-l": null, "volume": null, "issue": null, "pages": "1-19"}, "abstract": "To examine the psychometric properties of the Norwegian version of the Fear of COVID-19 Scale (FCV-19S), randomly selected individuals from a larger registry study were invited. We assessed the reliability and validity of the instrument in a sample of 1089 adults in Norway (response rate 73%). Internal consistency measured by Cronbach's alpha (0.88) was acceptable. Omega alphaHierarchical ( \u03c9t = 0.69) was lower indicating that the general factor is less reliable, explaining 69% of the total variance. Confirmatory factor analysis indicated that the FCV-19S is not strictly unidimensional. Exploratory graph analysis and confirmatory factor analysis supported a two-factor model (cognitive and somatic fear), which were highly correlated (r = 0.84). The Norwegian version of the FCV-19S showed an underlying two-factor structure. However, the high correlation means the two latent factors (cognitive and somatic fear) act as indicators for a second-order general factor and support use of the FCV-19S sum score. The FCV-19S appears to be a valid instrument to assess fear of COVID-19 with good psychometric properties.\r\n\r\nThe online version contains supplementary material available at 10.1007/s11469-020-00454-2.", "doi": "10.1007/s11469-020-00454-2", "pmid": "33495690", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "454"}, {"db": "pmc", "key": "PMC7816751"}], "notes": [], "created": "2021-01-29T15:26:14.525Z", "modified": "2021-06-18T11:11:42.948Z"}, {"entity": "publication", "iuid": "7e73071b4d804ba5bc0bf4d6733322a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e73071b4d804ba5bc0bf4d6733322a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e73071b4d804ba5bc0bf4d6733322a1"}}, "title": "Six-Month Survival After Extracorporeal Membrane Oxygenation for Severe COVID-19.", "authors": [{"family": "Biancari", "given": "Fausto", "initials": "F"}, {"family": "Mariscalco", "given": "Giovanni", "initials": "G"}, {"family": "Dal\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Settembre", "given": "Nicla", "initials": "N"}, {"family": "Welp", "given": "Henryk", "initials": "H"}, {"family": "Perrotti", "given": "Andrea", "initials": "A"}, {"family": "Wiebe", "given": "Karsten", "initials": "K"}, {"family": "Leo", "given": "Enrico", "initials": "E"}, {"family": "Loforte", "given": "Antonio", "initials": "A"}, {"family": "Chocron", "given": "Sidney", "initials": "S"}, {"family": "Pacini", "given": "Davide", "initials": "D"}, {"family": "Juvonen", "given": "Tatu", "initials": "T"}, {"family": "Broman", "given": "L Mikael", "initials": "LM"}, {"family": "Perna", "given": "Dario Di", "initials": "DD"}, {"family": "Yusuff", "given": "Hakeem", "initials": "H"}, {"family": "Harvey", "given": "Chris", "initials": "C"}, {"family": "Mongardon", "given": "Nicolas", "initials": "N"}, {"family": "Maureira", "given": "Juan P", "initials": "JP"}, {"family": "Levy", "given": "Bruno", "initials": "B"}, {"family": "Falk", "given": "Lars", "initials": "L"}, {"family": "Ruggieri", "given": "Vito G", "initials": "VG"}, {"family": "Zipfel", "given": "Svante", "initials": "S"}, {"family": "Folliguet", "given": "Thierry", "initials": "T"}, {"family": "Fiore", "given": "Antonio", "initials": "A"}], "type": "journal article", "published": "2021-01-19", "journal": {"title": "J Cardiothorac Vasc Anesth", "issn": "1532-8422", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The authors evaluated the outcome of adult patients with coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS) requiring the use of extracorporeal membrane oxygenation (ECMO).\r\n\r\nMulticenter retrospective, observational study.\r\n\r\nTen tertiary referral university and community hospitals.\r\n\r\nPatients with confirmed severe COVID-19-related ARDS.\r\n\r\nVenovenous or venoarterial ECMO.\r\n\r\nOne hundred thirty-two patients (mean age 51.1 \u00b1 9.7 years, female 17.4%) were treated with ECMO for confirmed severe COVID-19-related ARDS. Before ECMO, the mean Sequential Organ Failure Assessment score was 10.1 \u00b1 4.4, mean pH was 7.23 \u00b1 0.09, and mean PaO 2/fraction of inspired oxygen ratio was 77 \u00b1 50 mmHg. Venovenous ECMO was adopted in 122 patients (92.4%) and venoarterial ECMO in ten patients (7.6%) (mean duration, 14.6 \u00b1 11.0 days). Sixty-three (47.7%) patients died on ECMO and 70 (53.0%) during the index hospitalization. Six-month all-cause mortality was 53.0%. Advanced age (per year, hazard ratio [HR] 1.026, 95% CI 1.000-1-052) and low arterial pH (per unit, HR 0.006, 95% CI 0.000-0.083) before ECMO were the only baseline variables associated with increased risk of six-month mortality.\r\n\r\nThe present findings suggested that about half of adult patients with severe COVID-19-related ARDS can be managed successfully with ECMO with sustained results at six months. Decreased arterial pH before ECMO was associated significantly with early mortality. Therefore, the authors hypothesized that initiation of ECMO therapy before severe metabolic derangements subset may improve survival rates significantly in these patients. These results should be viewed in the light of a strict patient selection policy and may not be replicated in patients with advanced age or multiple comorbidities.\r\n\r\nidentifier, NCT04383678.", "doi": "10.1053/j.jvca.2021.01.027", "pmid": "33573928", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1053-0770(21)00062-8"}, {"db": "ClinicalTrials.gov", "key": "NCT04383678", "description": null}], "notes": [], "created": "2021-02-15T17:22:42.437Z", "modified": "2021-06-18T10:58:38.790Z"}, {"entity": "publication", "iuid": "5ade1e95279441e0bb8db1a9d3d813fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5ade1e95279441e0bb8db1a9d3d813fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5ade1e95279441e0bb8db1a9d3d813fa"}}, "title": "Nursing students' experiences of a pedagogical transition from campus learning to distance learning using digital tools.", "authors": [{"family": "Langeg\u00e5rd", "given": "Ulrica", "initials": "U"}, {"family": "Kiani", "given": "Kiana", "initials": "K"}, {"family": "Nielsen", "given": "Susanne J", "initials": "SJ"}, {"family": "Svensson", "given": "Per-Arne", "initials": "P"}], "type": "journal article", "published": "2021-01-19", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "issn-l": null, "volume": "20", "issue": "1", "pages": "23"}, "abstract": "The use of distance education using digital tools in higher education has increased over the last decade, particularly during the COVID-19 pandemic. Therefore, this study aimed to describe and evaluate nursing students' experiences of the pedagogical transition from traditional campus based learning to distance learning using digital tools.\r\n\r\nThe nursing course Symptom and signs of illness underwent a transition from campus based education to distance learning using digital tools because of the COVID-19 pandemic. This pedagogical transition in teaching was evaluated using both quantitative and qualitative data analysis. Focus group interviews (n = 9) were analysed using qualitative content analysis to explore students' experiences of the pedagogical transition and to construct a web-based questionnaire. The questionnaire comprised 14 items, including two open-ended questions. The questionnaire was delivered to all course participants and responses were obtained from 96 of 132 students (73%). Questionnaire data were analyzed using descriptive statistics and comments from the open-ended questions were used as quotes to highlight the quantitative data.\r\n\r\nThe analysis of the focus group interviews extracted three main dimensions: didactic aspects of digital teaching, study environment, and students' own resources. Social interaction was an overall theme included in all three dimensions. Data from the questionnaire showed that a majority of students preferred campus based education and experienced deterioration in all investigated dimensions after the pedagogical transition. However, approximately one-third of the students appeared to prefer distance learning using digital tools.\r\n\r\nThe main finding was that the pedagogical transition to distance education reduced the possibility for students' social interactions in their learning process. This negatively affected several aspects of their experience of distance learning using digital tools, such as reduced motivation. However, the heterogeneity in the responses suggested that a blended learning approach may offer pedagogical benefits while maintaining an advantageous level of social interaction.", "doi": "10.1186/s12912-021-00542-1", "pmid": "33468132", "labels": {"Type: Journal article": null, "Research Area: High-throughput and high-content serology": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12912-021-00542-1"}, {"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-22T09:14:27.260Z", "modified": "2021-06-18T11:10:06.280Z"}, {"entity": "publication", "iuid": "f0e04cdd04a8471ebde402406ab8ab24", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f0e04cdd04a8471ebde402406ab8ab24.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f0e04cdd04a8471ebde402406ab8ab24"}}, "title": "Human species D adenovirus hexon capsid protein mediates cell entry through a direct interaction with CD46.", "authors": [{"family": "Persson", "given": "B David", "initials": "BD"}, {"family": "John", "given": "Lijo", "initials": "L"}, {"family": "Rafie", "given": "Karim", "initials": "K"}, {"family": "Strebl", "given": "Michael", "initials": "M"}, {"family": "Fr\u00e4ngsmyr", "given": "Lars", "initials": "L"}, {"family": "Ballmann", "given": "Monika Z", "initials": "MZ"}, {"family": "Mindler", "given": "Katja", "initials": "K"}, {"family": "Havenga", "given": "Menzo", "initials": "M"}, {"family": "Lemckert", "given": "Angelique", "initials": "A"}, {"family": "Stehle", "given": "Thilo", "initials": "T"}, {"family": "Carlson", "given": "Lars-Anders", "initials": "LA"}, {"family": "Arnberg", "given": "Niklas", "initials": "N"}], "type": "journal article", "published": "2021-01-19", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "118", "issue": "3", "issn-l": "0027-8424"}, "abstract": "Human adenovirus species D (HAdV-D) types are currently being explored as vaccine vectors for coronavirus disease 2019 (COVID-19) and other severe infectious diseases. The efficacy of such vector-based vaccines depends on functional interactions with receptors on host cells. Adenoviruses of different species are assumed to enter host cells mainly by interactions between the knob domain of the protruding fiber capsid protein and cellular receptors. Using a cell-based receptor-screening assay, we identified CD46 as a receptor for HAdV-D56. The function of CD46 was validated in infection experiments using cells lacking and overexpressing CD46, and by competition infection experiments using soluble CD46. Remarkably, unlike HAdV-B types that engage CD46 through interactions with the knob domain of the fiber protein, HAdV-D types infect host cells through a direct interaction between CD46 and the hexon protein. Soluble hexon proteins (but not fiber knob) inhibited HAdV-D56 infection, and surface plasmon analyses demonstrated that CD46 binds to HAdV-D hexon (but not fiber knob) proteins. Cryoelectron microscopy analysis of the HAdV-D56 virion-CD46 complex confirmed the interaction and showed that CD46 binds to the central cavity of hexon trimers. Finally, soluble CD46 inhibited infection by 16 out of 17 investigated HAdV-D types, suggesting that CD46 is an important receptor for a large group of adenoviruses. In conclusion, this study identifies a noncanonical entry mechanism used by human adenoviruses, which adds to the knowledge of adenovirus biology and can also be useful for development of adenovirus-based vaccine vectors.", "doi": "10.1073/pnas.2020732118", "pmid": "33384338", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "2020732118"}, {"db": "PDB", "key": "7AJP", "description": "Crystal Structure of Human Adenovirus 56 Fiber Knob"}], "notes": [], "created": "2021-01-07T11:46:55.276Z", "modified": "2021-03-08T13:05:30.572Z"}, {"entity": "publication", "iuid": "19be7cdb189c4ea5b5d140fccdbc9908", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19be7cdb189c4ea5b5d140fccdbc9908.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19be7cdb189c4ea5b5d140fccdbc9908"}}, "title": "Psychological Impact of COVID-19 Cases on Medical Staff of Beijing Xiaotangshan Hospital.", "authors": [{"family": "Fu", "given": "Yuanbo", "initials": "Y"}, {"family": "Wang", "given": "Mina", "initials": "M"}, {"family": "Zhao", "given": "Bingcong", "initials": "B"}, {"family": "Liu", "given": "Baoli", "initials": "B"}, {"family": "Sun", "given": "Jie", "initials": "J"}, {"family": "Feng", "given": "Yaohui", "initials": "Y"}, {"family": "Wang", "given": "Zhengfang", "initials": "Z"}, {"family": "Li", "given": "Qian", "initials": "Q"}, {"family": "Shi", "given": "Chunhong", "initials": "C"}, {"family": "Xuan", "given": "Yabo", "initials": "Y"}, {"family": "Long", "given": "Siqi", "initials": "S"}, {"family": "Liu", "given": "Huan", "initials": "H"}, {"family": "Chi", "given": "Tiange", "initials": "T"}, {"family": "Liao", "given": "Zehuan", "initials": "Z"}, {"family": "Li", "given": "Bin", "initials": "B"}, {"family": "Liu", "given": "Qingquan", "initials": "Q"}], "type": "journal article", "published": "2021-01-18", "journal": {"title": "Psychol Res Behav Manag", "issn": "1179-1578", "volume": "14", "issue": null, "pages": "41-47", "issn-l": null}, "abstract": "To investigate the psychological impact of cases of coronavirus disease 19 (COVID-19) on medical staff of Beijing Xiaotangshan Hospital.\n\nThe 287 online questionnaires were distributed to medical staff working at Beijing Xiaotangshan Hospital, comprising three main sections and 17 questions: basic information, current departmental position, and the 12-item General Health Questionnaire (GHQ-12). The threshold for emotional distress was defined to be a total score of 4 on the GHQ-12 and above.\n\nA total of 255 members of medical staff participating in this study presented an emotional distress rate of 17%. Members who were male, aged 50-59, married with children, positioned as doctors, and in administration were the population with the highest rate of emotional distress. Furthermore, the severity of emotional distress among those under 30 was significantly lower than those aged 30-39 and 50-59. Doctors and other occupations shared a lower level of satisfaction on routine activities compared with nurses, so did staff in the administration compared with those who were working in screening or logistic departments. Besides, males and staff of the confirmation department had more difficulty in concentrating than females and those of the screening department, respectively.\n\nMedical staff working at Xiaotangshan Hospital underwent relatively low levels of emotional distress thanks to sufficient medical and psychological preparations. However, special attention should be paid to those who were male, married with children, senior, doctors, in administration, and in the confirmation department.", "doi": "10.2147/PRBM.S287842", "pmid": "33500670", "labels": {"Type: Journal article": null, "Category: Proteins": null}, "xrefs": [{"db": "pii", "key": "287842"}, {"db": "pmc", "key": "PMC7822226"}], "notes": [], "created": "2021-01-29T15:20:19.301Z", "modified": "2021-02-26T08:47:18.761Z"}, {"entity": "publication", "iuid": "de8e43af8fbc4fce91a5e2e0a2f872d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/de8e43af8fbc4fce91a5e2e0a2f872d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/de8e43af8fbc4fce91a5e2e0a2f872d5"}}, "title": "Unrecognized risks and challenges of water as a major focus of COVID-19 spread.", "authors": [{"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}, {"family": "Burkle", "given": "Frederick M", "initials": "FM"}], "type": "journal article", "published": "2021-01-16", "journal": {"title": "J Glob Health", "issn": "2047-2986", "volume": "11", "issue": null, "pages": "03016", "issn-l": "2047-2978"}, "abstract": null, "doi": "10.7189/jogh.11.03016", "pmid": "33643626", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jogh-11-03016"}, {"db": "pmc", "key": "PMC7898659"}], "notes": [], "created": "2021-03-02T06:55:40.108Z", "modified": "2021-03-02T06:55:40.119Z"}, {"entity": "publication", "iuid": "db584bed80c945d6a6c6def84a90cf1b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/db584bed80c945d6a6c6def84a90cf1b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/db584bed80c945d6a6c6def84a90cf1b"}}, "title": "Sleep in Female Healthcare Workers during COVID-19: A Cross-sectional Survey Study in Sweden during the Flattening of the First Wave of the Pandemic.", "authors": [{"family": "Benedict", "given": "Christian", "initials": "C"}, {"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J"}], "type": "journal article", "published": "2021-01-15", "journal": {"title": "Ann Am Thorac Soc", "issn": "2325-6621", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1513/AnnalsATS.202101-019RL", "pmid": "33448898", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-18T14:37:02.564Z", "modified": "2021-01-18T14:37:02.581Z"}, {"entity": "publication", "iuid": "cb790b6fefa748598789c57ca0388216", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cb790b6fefa748598789c57ca0388216.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cb790b6fefa748598789c57ca0388216"}}, "title": "Serum Renin Levels Increase With Age in Boys Resulting in Higher Renin Levels in Young Men Compared to Young Women, and Soluble Angiotensin-Converting Enzyme 2 Correlates With Renin and Body Mass Index.", "authors": [{"family": "Jehpsson", "given": "Lars", "initials": "L"}, {"family": "Sun", "given": "Jiangming", "initials": "J"}, {"family": "Nilsson", "given": "Peter M", "initials": "PM"}, {"family": "Edsfeldt", "given": "Andreas", "initials": "A"}, {"family": "Sw\u00e4rd", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2021-01-15", "journal": {"title": "Front Physiol", "issn": "1664-042X", "issn-l": null, "volume": "11", "issue": null, "pages": "622179"}, "abstract": "Background: Age, sex, and body constitution may affect the shedding of membrane bound angiotensin-converting enzyme 2 (mACE2) and lead to a relative mACE2 deficiency. However, it is unclear if differences, reflected by serum renin levels, exist in the basal renin-angiotensin-system (RAS) between children and adults, boys, and girls as well as young women and young men. Furthermore, it remains to be investigated if renin and soluble ACE2 (sACE2) levels are correlated with body mass index (BMI) in children and young adults. The aim of this observational study was to assess age-and sex differences in serum renin, and the relationship between renin, soluble angiotensin-converting enzyme 2, and body mass index in a prospectively followed population-based cohort of children which were followed into young adulthood. Study Design: We analyzed renin and sACE2 in serum in a prospectively followed population-based cohort at 9.9 (0.6) [mean (SD)] (n = 173), 11.7 (0.6) (n = 156), 14.8 (0.8) (n = 149), 18.8 (0.3) (n = 93), and 23.5 (0.7) (n = 152) years of age. Height (cm) and weight (kg) was measured and body mass index (BMI) was calculated as weight (kg)/height (m)2. Sex-related differences in renin levels were calculated using analysis of covariance, adjusted for age. Correlations were assessed by calculating the correlation coefficient (R2) using a multivariable linear mixed model. Results: Both sexes had low renin levels up to 12 years of age. Thereafter renin levels increased more in boys than in girls. Males from the age of 15 had significantly higher levels than females (p < 0.001). There was a positive linear relationship between renin and sACE2 levels in male and female subjects (p < 0.001), and between sACE2 levels and BMI in males (p < 0.001). Conclusion: Renin levels increase with age, are higher in men than in women since around puberty, and are correlated with sACE2 levels. Furthermore, sACE2 levels are correlated with body mass index in males. These findings indicate that high renin levels in males and females and a high BMI in males may activate pathways which increase the shedding of mACE2, with possible implications for the risk of severe coronavirus disease 2019.", "doi": "10.3389/fphys.2020.622179", "pmid": "33519526", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7844344"}], "notes": [], "created": "2021-02-04T18:35:07.586Z", "modified": "2021-06-18T10:52:15.052Z"}, {"entity": "publication", "iuid": "8f2208ef80cc47daaf609e804bba5feb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f2208ef80cc47daaf609e804bba5feb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f2208ef80cc47daaf609e804bba5feb"}}, "title": "Elevated Angiopoietin-2 inhibits thrombomodulin-mediated anticoagulation in critically ill COVID-19 patients", "authors": [{"family": "Hultstrom", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Fromell", "given": "Karin", "initials": "K", "orcid": "0000-0001-8905-8791", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9342eb4305954aba853bdf3a8153ab67.json"}}, {"family": "Larsson", "given": "Anders", "initials": "A", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc2be858ab604743b72383dfdcd14689.json"}}, {"family": "Quaggin", "given": "Susan E", "initials": "SE", "orcid": "0000-0002-3706-5727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a72116a70bfc48a69063ca0d3454123f.json"}}, {"family": "Betsholtz", "given": "Christer", "initials": "C", "orcid": "0000-0002-8494-971X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/22ce9638bcd9467d812ca8adc65001d4.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Lipcsey", "given": "Miklos", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2821ac6ac354cc89005f56efea565fa.json"}}, {"family": "Jeansson", "given": "Marie", "initials": "M", "orcid": "0000-0003-1075-8563", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ae2c63715b0f4a5b8127552ab84a1bf3.json"}}], "type": "posted-content", "published": "2021-01-15", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.01.13.21249429", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null, "Funder: VR": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biobanks for COVID-19 research": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.17044/scilifelab.14229410.v1", "description": "Metadata record"}], "notes": [], "created": "2021-01-18T18:27:26.562Z", "modified": "2021-12-12T18:07:08.439Z"}, {"entity": "publication", "iuid": "9fa7133f2c2b4605b375cd6003754209", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9fa7133f2c2b4605b375cd6003754209.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9fa7133f2c2b4605b375cd6003754209"}}, "title": "Utilisation, Availability and Price Changes of Medicines and Protection Equipment for COVID-19 Among Selected Regions in India: Findings and Implications", "authors": [{"family": "Haque", "given": "Mainul", "initials": "M"}, {"family": "Kumar", "given": "Santosh", "initials": "S"}, {"family": "Charan", "given": "Jaykaran", "initials": "J"}, {"family": "Bhatt", "given": "Rohan", "initials": "R"}, {"family": "Islam", "given": "Salequl", "initials": "S"}, {"family": "Dutta", "given": "Siddhartha", "initials": "S"}, {"family": "Abhayanand", "given": "Jha Pallavi", "initials": "JP"}, {"family": "Sharma", "given": "Yesh", "initials": "Y"}, {"family": "Sefah", "given": "Israel", "initials": "I"}, {"family": "Kurdi", "given": "Amanj", "initials": "A"}, {"family": "Wale", "given": "Janney", "initials": "J"}, {"family": "Godman", "given": "Brian", "initials": "B"}], "type": "journal-article", "published": "2021-01-14", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "11", "issue": null, "pages": null, "issn-l": "1663-9812"}, "abstract": null, "doi": "10.3389/fphar.2020.582154", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-25T12:36:36.412Z", "modified": "2021-02-26T08:47:00.115Z"}, {"entity": "publication", "iuid": "e44cd62c93dc4ec5a51853a95aa15322", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e44cd62c93dc4ec5a51853a95aa15322.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e44cd62c93dc4ec5a51853a95aa15322"}}, "title": "The Impact of COVID-19 on In-Hospital Outcomes of ST-Segment Elevation Myocardial Infarction Patients.", "authors": [{"family": "Ayad", "given": "Sherif", "initials": "S"}, {"family": "Shenouda", "given": "Rafik", "initials": "R"}, {"family": "Henein", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2021-01-14", "journal": {"title": "J Clin Med", "issn": "2077-0383", "issn-l": "2077-0383", "volume": "10", "issue": "2", "pages": null}, "abstract": "Primary percutaneous coronary intervention (PPCI) is one of the important clinical procedures that have been affected by the COVID-19 pandemic. In this study, we aimed to assess the incidence and impact of COVID-19 on in-hospital clinical outcome of ST elevation myocardial infarction (STEMI) patients managed with PPCI. This observational retrospective study was conducted on consecutive STEMI patients who presented to the International Cardiac Center (ICC) hospital, Alexandria, Egypt between 1 February and 31 October 2020. A group of STEMI patients presented during the same period in 2019 was also assessed (control group) and data was used for comparison. The inclusion criteria were established diagnosis of STEMI requiring PPCI.A total of 634 patients were included in the study. During the COVID-19 period, the number of PPCI procedures was reduced by 25.7% compared with previous year (mean 30.0 \u00b1 4.01 vs. 40.4 \u00b1 5.3 case/month) and the time from first medical contact to Needle (FMC-to-N) was longer (125.0 \u00b1 53.6 vs. 52.6 \u00b1 22.8 min, p = 0.001). Also, during COVID-19, the in-hospital mortality was higher (7.4 vs. 4.6%, p = 0.036) as was the incidence of re-infarction (12.2 vs. 7.7%, p = 0.041) and the need for revascularization (15.9 vs. 10.7%, p = 0.046). The incidence of heart failure, stroke, and bleeding was not different between groups, but hospital stay was longer during COVID-19 (6.85 \u00b1 4.22 vs. 3.5 \u00b1 2.3 day, p = 0.0025). Conclusion: At the ICC, COVID-19 pandemic contributed significantly to the PPCI management of STEMI patients with decreased number and delayed procedures. COVID-19 was also associated with higher in-hospital mortality, rate of re-infarction, need for revascularization, and longer hospital stay.", "doi": "10.3390/jcm10020278", "pmid": "33466588", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "jcm10020278"}], "notes": [], "created": "2021-01-22T09:16:39.182Z", "modified": "2021-06-18T10:51:57.424Z"}, {"entity": "publication", "iuid": "9ffbffb4b03446888ea96e3df6f24fa8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ffbffb4b03446888ea96e3df6f24fa8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ffbffb4b03446888ea96e3df6f24fa8"}}, "title": "Self-Perceived Changes in Physical Activity and the Relation to Life Satisfaction and Rated Physical Capacity in Swedish Adults during the COVID-19 Pandemic-A Cross Sectional Study.", "authors": [{"family": "Eek", "given": "Frida", "initials": "F"}, {"family": "Larsson", "given": "Caroline", "initials": "C"}, {"family": "Wis\u00e9n", "given": "Anita", "initials": "A"}, {"family": "Ekvall Hansson", "given": "Eva", "initials": "E"}], "type": "journal article", "published": "2021-01-14", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "18", "issue": "2", "pages": null}, "abstract": "COVID-19 restrictions may prevent people from reaching recommended levels of physical activity (PA). This study examines self-perceived changes in the extent and intensity of PA during the COVID-19 pandemic, and the relation between perceived changes in PA and general life satisfaction and perceived physical capacity. A total of 1318 participants (mean age 47.8 SD12.6; 82.1% women) were recruited through social media in Sweden during autumn 2020. The survey included questions regarding perceived changes in PA compared to the previous year, the \"Rating of Perceived Capacity\" scale and \"Life Satisfaction Questionnaire-11\". A change in PA was reported by 65% of participants. More participants reported an increase (36%) than a decrease (29%), however a decrease in PA was significantly more often considered to be due to the pandemic. The highest odds of decreased PA was found in the oldest age group (70+ years) (OR 2.8; 95% CI 1.4-5.7). Those who reported decreased levels of PA reported lower life satisfaction and aerobic capacity than the other groups ( p > 0.001). Decreased physical activity was reported by many, but an equal share reported increased activity during the pandemic. The highest odds for decreased activity was found in the oldest group-the group that has been subjected to the strictest recommended COVID-19 restrictions in Sweden.", "doi": "10.3390/ijerph18020671", "pmid": "33466860", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph18020671"}], "notes": [], "created": "2021-01-22T09:15:10.766Z", "modified": "2021-06-18T11:03:45.303Z"}, {"entity": "publication", "iuid": "be702d32c1414faf947340a12462b206", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be702d32c1414faf947340a12462b206.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be702d32c1414faf947340a12462b206"}}, "title": "SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice", "authors": [{"family": "Tian", "given": "Jing Hui", "initials": "JH"}, {"family": "Patel", "given": "Nita", "initials": "N"}, {"family": "Haupt", "given": "Robert", "initials": "R"}, {"family": "Zhou", "given": "Haixia", "initials": "H"}, {"family": "Weston", "given": "Stuart", "initials": "S"}, {"family": "Hammond", "given": "Holly", "initials": "H"}, {"family": "Logue", "given": "James", "initials": "J"}, {"family": "Portnoff", "given": "Alyse D", "initials": "AD"}, {"family": "Norton", "given": "James", "initials": "J"}, {"family": "Guebre-Xabier", "given": "Mimi", "initials": "M"}, {"family": "Zhou", "given": "Bin", "initials": "B"}, {"family": "Jacobson", "given": "Kelsey", "initials": "K"}, {"family": "Maciejewski", "given": "Sonia", "initials": "S"}, {"family": "Khatoon", "given": "Rafia", "initials": "R"}, {"family": "Wisniewska", "given": "Malgorzata", "initials": "M"}, {"family": "Moffitt", "given": "Will", "initials": "W"}, {"family": "Kluepfel-Stahl", "given": "Stefanie", "initials": "S"}, {"family": "Ekechukwu", "given": "Betty", "initials": "B"}, {"family": "Papin", "given": "James", "initials": "J"}, {"family": "Boddapati", "given": "Sarathi", "initials": "S"}, {"family": "Jason Wong", "given": "C", "initials": "C"}, {"family": "Piedra", "given": "Pedro A", "initials": "PA"}, {"family": "Frieman", "given": "Matthew B", "initials": "MB"}, {"family": "Massare", "given": "Michael J", "initials": "MJ"}, {"family": "Fries", "given": "Louis", "initials": "L"}, {"family": "Bengtsson", "given": "Karin L\u00f6vgren", "initials": "KL"}, {"family": "Stertman", "given": "Linda", "initials": "L"}, {"family": "Ellingsworth", "given": "Larry", "initials": "L"}, {"family": "Glenn", "given": "Gregory", "initials": "G"}, {"family": "Smith", "given": "Gale", "initials": "G"}], "type": "journal-article", "published": "2021-01-14", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "372"}, "abstract": "The COVID-19 pandemic continues to spread throughout the world with an urgent need for a safe and protective vaccine to effectuate herd protection and control the spread of SARS-CoV-2. Here, we report the development of a SARS-CoV-2 subunit vaccine (NVX-CoV2373) from the full-length spike (S) protein that is stable in the prefusion conformation. NVX-CoV2373 S form 27.2-nm nanoparticles that are thermostable and bind with high affinity to the human angiotensin-converting enzyme 2 (hACE2) receptor. In mice, low-dose NVX-CoV2373 with saponin-based Matrix-M adjuvant elicit high titer anti-S IgG that blocks hACE2 receptor binding, neutralize virus, and protects against SARS-CoV-2 challenge with no evidence of vaccine-associated enhanced respiratory disease. NVX-CoV2373 also elicits multifunctional CD4 + and CD8+ T cells, CD4+ follicular helper T cells (Tfh), and antigen-specific germinal center (GC) B cells in the spleen. In baboons, low-dose levels of NVX-CoV2373 with Matrix-M was also highly immunogenic and elicited high titer anti-S antibodies and functional antibodies that block S-protein binding to hACE2 and neutralize virus infection and antigen-specific T cells. These results support the ongoing phase 1/2 clinical evaluation of the safety and immunogenicity of NVX-CoV2373 with Matrix-M (NCT04368988).", "doi": "10.1038/s41467-020-20653-8", "pmid": "33446655", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null, "Category: Vaccines": null}, "xrefs": [{"db": "URL", "key": "https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-020-20653-8/MediaObjects/41467_2020_20653_MOESM4_ESM.xlsx", "description": "Various raw data"}], "notes": [], "created": "2021-01-15T13:07:39.769Z", "modified": "2021-12-07T15:31:17.780Z"}, {"entity": "publication", "iuid": "eabd601758b541d6964027948b408314", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eabd601758b541d6964027948b408314.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eabd601758b541d6964027948b408314"}}, "title": "Real-time monitoring shows substantial excess all-cause mortality during second wave of COVID-19 in Europe, October to December 2020", "authors": [{"family": "N\u00f8rgaard", "given": "Sarah K", "initials": "SK"}, {"family": "Vestergaard", "given": "Lasse S", "initials": "LS"}, {"family": "Nielsen", "given": "Jens", "initials": "J"}, {"family": "Richter", "given": "Lukas", "initials": "L"}, {"family": "Schmid", "given": "Daniela", "initials": "D"}, {"family": "Bustos", "given": "Natalia", "initials": "N"}, {"family": "Braye", "given": "Toon", "initials": "T"}, {"family": "Athanasiadou", "given": "Maria", "initials": "M"}, {"family": "Lytras", "given": "Theodore", "initials": "T"}, {"family": "Denissov", "given": "Gleb", "initials": "G"}, {"family": "Veideman", "given": "Tatjana", "initials": "T"}, {"family": "Luomala", "given": "Oskari", "initials": "O"}, {"family": "M\u00f6tt\u00f6nen", "given": "Teemu", "initials": "T"}, {"family": "Fouillet", "given": "Anne", "initials": "A"}, {"family": "Caserio-Sch\u00f6nemann", "given": "C\u00e9line", "initials": "C"}, {"family": "an der Heiden", "given": "Matthias", "initials": "M"}, {"family": "Uphoff", "given": "Helmut", "initials": "H"}, {"family": "Gkolfinopoulou", "given": "Kassiani", "initials": "K"}, {"family": "Bobvos", "given": "Janos", "initials": "J"}, {"family": "Paldy", "given": "Anna", "initials": "A"}, {"family": "Rotem", "given": "Naama", "initials": "N"}, {"family": "Kornilenko", "given": "Irene", "initials": "I"}, {"family": "Domegan", "given": "Lisa", "initials": "L"}, {"family": "O\u2019Donnell", "given": "Joan", "initials": "J"}, {"family": "Donato", "given": "Francesca De", "initials": "FD"}, {"family": "Scortichini", "given": "Matteo", "initials": "M"}, {"family": "Hoffmann", "given": "Patrick", "initials": "P"}, {"family": "Velez", "given": "Telma", "initials": "T"}, {"family": "England", "given": "Kathleen", "initials": "K"}, {"family": "Calleja", "given": "Neville", "initials": "N"}, {"family": "van Asten", "given": "Liselotte", "initials": "L"}, {"family": "Stoeldraijer", "given": "Lenny", "initials": "L"}, {"family": "White", "given": "Richard A", "initials": "RA"}, {"family": "Paulsen", "given": "Trine H", "initials": "TH"}, {"family": "da Silva", "given": "Susana P", "initials": "SP"}, {"family": "Rodrigues", "given": "Ana P", "initials": "AP"}, {"family": "Klepac", "given": "Petra", "initials": "P"}, {"family": "Zaletel", "given": "Metka", "initials": "M"}, {"family": "Fafangel", "given": "Mario", "initials": "M"}, {"family": "Larrauri", "given": "Amparo", "initials": "A"}, {"family": "Le\u00f3n", "given": "Inmaculada", "initials": "I"}, {"family": "Farah", "given": "Ahmed", "initials": "A"}, {"family": "Galanis", "given": "Ilias", "initials": "I"}, {"family": "Junker", "given": "Christoph", "initials": "C"}, {"family": "Perisa", "given": "Damir", "initials": "D"}, {"family": "Sinnathamby", "given": "Mary", "initials": "M"}, {"family": "Andrews", "given": "Nick", "initials": "N"}, {"family": "O'Doherty", "given": "Mark G", "initials": "MG"}, {"family": "Irwin", "given": "David", "initials": "D"}, {"family": "Kennedy", "given": "Sharon", "initials": "S"}, {"family": "McMenamin", "given": "Jim", "initials": "J"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Penttinen", "given": "Pasi", "initials": "P"}, {"family": "Pukkila", "given": "Jukka", "initials": "J"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "Krause", "given": "Tyra G", "initials": "TG"}, {"family": "M\u00f8lbak", "given": "K\u00e5re", "initials": "K"}], "type": "journal-article", "published": "2021-01-14", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "2", "pages": null}, "abstract": "The European monitoring of excess mortality for public health action (EuroMOMO) network monitors weekly excess all-cause mortality in 27 European countries or subnational areas. During the first wave of the coronavirus disease (COVID-19) pandemic in Europe in spring 2020, several countries experienced extraordinarily high levels of excess mortality. Europe is currently seeing another upsurge in COVID-19 cases, and EuroMOMO is again witnessing a substantial excess all-cause mortality attributable to COVID-19.", "doi": "10.2807/1560-7917.es.2021.26.1.2002023", "pmid": "33446304", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-15T13:12:07.264Z", "modified": "2021-06-18T10:59:36.865Z"}, {"entity": "publication", "iuid": "d1739e47fac748278f5a49d715423cc6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1739e47fac748278f5a49d715423cc6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1739e47fac748278f5a49d715423cc6"}}, "title": "Rapid Assessment of the Potential Paucity and Price Increases for Suggested Medicines and Protection Equipment for COVID-19 Across Developing Countries With a Particular Focus on Africa and the Implications", "authors": [{"family": "Sefah", "given": "Israel Abebrese", "initials": "IA"}, {"family": "Ogunleye", "given": "Olayinka O", "initials": "OO"}, {"family": "Essah", "given": "Darius Obeng", "initials": "DO"}, {"family": "Opanga", "given": "Sylvia A", "initials": "SA"}, {"family": "Butt", "given": "Nadia", "initials": "N"}, {"family": "Wamaitha", "given": "Annie", "initials": "A"}, {"family": "Guantai", "given": "Anastasia Nkatha", "initials": "AN"}, {"family": "Chikowe", "given": "Ibrahim", "initials": "I"}, {"family": "Khuluza", "given": "Felix", "initials": "F"}, {"family": "Kibuule", "given": "Dan", "initials": "D"}, {"family": "Nambahu", "given": "Lahya", "initials": "L"}, {"family": "Abubakar", "given": "Abdullahi Rabiu", "initials": "AR"}, {"family": "Sani", "given": "Ibrahim Haruna", "initials": "IH"}, {"family": "Saleem", "given": "Zikria", "initials": "Z"}, {"family": "Kalungia", "given": "Aubrey C", "initials": "AC"}, {"family": "Thi Phuong", "given": "Thuy Nguyen", "initials": "TN"}, {"family": "Haque", "given": "Mainul", "initials": "M"}, {"family": "Islam", "given": "Salequl", "initials": "S"}, {"family": "Kumar", "given": "Santosh", "initials": "S"}, {"family": "Sneddon", "given": "Jacqueline", "initials": "J"}, {"family": "Wamboga", "given": "Joshua", "initials": "J"}, {"family": "Wale", "given": "Janney", "initials": "J"}, {"family": "Miljkovi\u0107", "given": "Nenad", "initials": "N"}, {"family": "Kurdi", "given": "Amanj", "initials": "A"}, {"family": "Martin", "given": "Antony P", "initials": "AP"}, {"family": "Godman", "given": "Brian", "initials": "B"}], "type": "journal-article", "published": "2021-01-14", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "11", "issue": null, "pages": null, "issn-l": "1663-9812"}, "abstract": null, "doi": "10.3389/fphar.2020.588106", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-02-25T12:33:08.337Z", "modified": "2021-02-26T08:47:00.209Z"}, {"entity": "publication", "iuid": "8a9fd3c3b0244e3e81860d7dc98d9a3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a9fd3c3b0244e3e81860d7dc98d9a3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a9fd3c3b0244e3e81860d7dc98d9a3d"}}, "title": "Malpractice claimed calls within the Swedish Healthcare Direct: a descriptive \u2013 comparative case study", "authors": [{"family": "Bj\u00f6rkman", "given": "Annica", "initials": "A"}, {"family": "Engstr\u00f6m", "given": "Maria", "initials": "M"}, {"family": "Winblad", "given": "Ulrika", "initials": "U"}, {"family": "Holmstr\u00f6m", "given": "Inger K", "initials": "IK"}], "type": "journal-article", "published": "2021-01-14", "journal": {"title": "BMC Nurs", "issn": "1472-6955", "issn-l": null, "volume": "20", "issue": "1", "pages": null}, "abstract": null, "doi": "10.1186/s12912-021-00540-3", "pmid": "33446213", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-15T13:13:41.154Z", "modified": "2021-06-18T11:06:59.592Z"}, {"entity": "publication", "iuid": "5e357bc3280e4a6c8fb860e54818e86c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e357bc3280e4a6c8fb860e54818e86c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e357bc3280e4a6c8fb860e54818e86c"}}, "title": "Stress und Covid-19: Ein Narrativer Review \u00fcber neuroendokrin-immune Mechanismen, die eine Abwehr von SARS-CoV-2 verbessern k\u00f6nnten", "authors": [{"family": "Peters", "given": "Eva Milena Johanne", "initials": "EMJ"}, {"family": "Schedlowski", "given": "Manfred", "initials": "M"}, {"family": "Watzl", "given": "Carsten", "initials": "C"}, {"family": "Gimsa", "given": "Ulrike", "initials": "U"}], "type": "journal-article", "published": "2021-01-13", "journal": {"title": "Psychother Psychosom Med Psychol", "issn": "0937-2032", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1055/a-1322-3205", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-15T13:16:23.754Z", "modified": "2021-02-26T08:46:59.974Z"}, {"entity": "publication", "iuid": "f856eeca79fd4a1c8b49192f0f2fe7e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f856eeca79fd4a1c8b49192f0f2fe7e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f856eeca79fd4a1c8b49192f0f2fe7e7"}}, "title": "Distinct lung-homing receptor expression and activation profiles on NK cell and T cell subsets in COVID-19 and influenza", "authors": [{"family": "Brownlie", "given": "Demi", "initials": "D"}, {"family": "R\u00f8dahl", "given": "Inga", "initials": "I"}, {"family": "Varnaite", "given": "Renata", "initials": "R"}, {"family": "Asgeirsson", "given": "Hilmir", "initials": "H"}, {"family": "Glans", "given": "Hedvig", "initials": "H"}, {"family": "Falck-Jones", "given": "Sara", "initials": "S"}, {"family": "Vangeti", "given": "Sindhu", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Ljunggren", "given": "Hans Gustaf", "initials": "HG"}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Marquardt", "given": "Nicole", "initials": "N"}], "type": "posted-content", "published": "2021-01-13", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.01.13.426553", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-15T14:19:16.762Z", "modified": "2022-06-21T18:22:46.189Z"}, {"entity": "publication", "iuid": "c7d80c74ef2c4621be717f223c622d54", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7d80c74ef2c4621be717f223c622d54.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7d80c74ef2c4621be717f223c622d54"}}, "title": "COVID-19 after kidney transplantation: Early outcome and renal function following antiviral treatment.", "authors": [{"family": "Elec", "given": "Alina Daciana", "initials": "AD"}, {"family": "Oltean", "given": "Mihai", "initials": "M"}, {"family": "Goldis", "given": "Patricia", "initials": "P"}, {"family": "Cismaru", "given": "Cristina", "initials": "C"}, {"family": "Lupse", "given": "Mihaela", "initials": "M"}, {"family": "Muntean", "given": "Adriana", "initials": "A"}, {"family": "Elec", "given": "Florin Ioan", "initials": "FI"}], "type": "journal article", "published": "2021-01-13", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "volume": null, "issue": null, "issn-l": "1201-9712"}, "abstract": "The lack of effective COVID-19 treatments mandated the repurposing of several drugs, including antiretrovirals (ARV) and remdesivir (RDV). These compounds may induce acute kidney injuries and are not recommended in patients with poor renal function, such as kidney transplant recipients (KTx).\n\nWe reviewed the records of 42 KTx with COVID-19, some of them receiving ARV (n = 10) or RDV (n = 8) as part of the COVID-19 management. Most patients were male (71%) with a median age of 52 years and median GFR 56 mL/min and had mild (36%), moderate (19%), severe (31%), and critical (12%) disease. Subgroups (patients receiving ARV, RDV, or no antivirals) were comparable regarding patient age, comorbidities or immunosuppression.\n\nSeven patients (16,6%) died during hospitalization. Acute kidney injury was found in 24% KTx at admission. Upon discharge, eGFR increased in 32% and decreased in 39% of the KTx compared with the admission. The decrease was more prevalent in the RDV group (80%) compared with KTx without any antiviral treatment (29%) (p < 0.05). Most patients (62%) returned to baseline eGFR values within one month from discharge. The proportion was similar between the patients receiving antiviral treatment or not.\n\nKTx run a high risk of COVID-19-related renal impairment. Antivirals appear safe for use without major risks for kidney injury.", "doi": "10.1016/j.ijid.2021.01.023", "pmid": "33453396", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(21)00033-3"}, {"db": "URL", "key": "https://www.ijidonline.com/cms/10.1016/j.ijid.2021.01.023/attachment/10ccf84a-9c50-4457-b428-6a46ea9babe3/mmc1.docx", "description": "Patient demographics, management and outcome in 42 kidney recipients with COVID-19"}], "notes": [], "created": "2021-01-18T14:38:18.532Z", "modified": "2021-06-18T10:44:28.575Z"}, {"entity": "publication", "iuid": "87c1ab20e64f4807aae86b805119e073", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87c1ab20e64f4807aae86b805119e073.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87c1ab20e64f4807aae86b805119e073"}}, "title": "Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape", "authors": [{"family": "Koenig", "given": "Paul Albert", "initials": "PA"}, {"family": "Das", "given": "Hrishikesh", "initials": "H"}, {"family": "Liu", "given": "Hejun", "initials": "H"}, {"family": "K\u00fcmmerer", "given": "Beate M", "initials": "BM"}, {"family": "Gohr", "given": "Florian N", "initials": "FN"}, {"family": "Jenster", "given": "Lea Marie", "initials": "LM"}, {"family": "Schiffelers", "given": "Lisa D J", "initials": "LDJ"}, {"family": "Tesfamariam", "given": "Yonas M", "initials": "YM"}, {"family": "Uchima", "given": "Miki", "initials": "M"}, {"family": "Wuerth", "given": "Jennifer D", "initials": "JD"}, {"family": "Gatterdam", "given": "Karl", "initials": "K"}, {"family": "Ruetalo", "given": "Natalia", "initials": "N"}, {"family": "Christensen", "given": "Maria H", "initials": "MH"}, {"family": "Fandrey", "given": "Caroline I", "initials": "CI"}, {"family": "Normann", "given": "Sabine", "initials": "S"}, {"family": "T\u00f6dtmann", "given": "Jan M P", "initials": "JMP"}, {"family": "Pritzl", "given": "Steffen", "initials": "S"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Boos", "given": "Jannik", "initials": "J"}, {"family": "Yuan", "given": "Meng", "initials": "M"}, {"family": "Zhu", "given": "Xueyong", "initials": "X"}, {"family": "Schmid-Burgk", "given": "Jonathan L", "initials": "JL"}, {"family": "Kato", "given": "Hiroki", "initials": "H"}, {"family": "Schindler", "given": "Michael", "initials": "M"}, {"family": "Wilson", "given": "Ian A", "initials": "IA"}, {"family": "Geyer", "given": "Matthias", "initials": "M"}, {"family": "Ludwig", "given": "Kerstin U", "initials": "KU"}, {"family": "H\u00e4llberg", "given": "B Martin", "initials": "BM"}, {"family": "Wu", "given": "Nicholas C", "initials": "NC"}, {"family": "Schmidt", "given": "Florian I", "initials": "FI"}], "type": "journal-article", "published": "2021-01-12", "journal": {"title": "Science", "issn": "0036-8075", "issn-l": null, "volume": "371", "issue": "6530", "pages": "eabe6230"}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to spread with devastating consequences. For passive immunization efforts, nanobodies have size and cost advantages over conventional antibodies. Here, we generated four neutralizing nanobodies that target the receptor-binding domain of the SARS-CoV-2 spike protein. We defined two distinct binding epitopes using x-ray crystallography and cryo-electron microscopy. Based on the structures, we engineered multivalent nanobodies with more than 100-fold improved neutralizing activity than monovalent nanobodies. Biparatopic nanobody fusions suppressed the emergence of escape mutants. Several nanobody constructs neutralized through receptor-binding competition, while other monovalent and biparatopic nanobodies triggered aberrant activation of the spike fusion machinery. These premature conformational changes in the spike protein forestalled productive fusion, and rendered the virions non-infectious.", "doi": "10.1126/science.abe6230", "pmid": "33436526", "labels": {"Type: Journal article": null, "Funder: H2020": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Imaging": null, "Category: Proteins": null}, "xrefs": [{"db": "PDB", "key": "7KN5", "description": "Crystal structure of SARS-CoV-2 RBD complexed with nanobodies VHH E and U"}, {"db": "PDB", "key": "7KN6", "description": "Crystal structure of SARS-CoV-2 RBD complexed with nanobody VHH V and antibody Fab CC12.3"}, {"db": "PDB", "key": "7KN7", "description": "Crystal structure of SARS-CoV-2 RBD complexed with nanobody VHH W and antibody Fab CC12.3"}, {"db": "URL", "key": "https://www.ebi.ac.uk/pdbe/entry/emdb/EMD-23018", "description": "EMD-23018"}, {"db": "PDB", "key": "7KSG", "description": "SARS-CoV-2 spike in complex with nanobodies E"}, {"db": "PDB", "key": "7B14", "description": "Nanobody E bound to Spike-RBD in a localized reconstruction."}, {"db": "PDB", "key": "7B11", "description": "SARS-CoV-spike with two RBDs up bound to VHH V on all RBDs"}, {"db": "PDB", "key": "7B18", "description": "SARS-CoV-spike bound to two neutralising nanobodies"}, {"db": "PDB", "key": "7B17", "description": "SARS-CoV-spike RBD bound to two neutralising nanobodies"}], "notes": [], "created": "2021-01-15T13:19:46.751Z", "modified": "2021-02-26T08:47:18.838Z"}, {"entity": "publication", "iuid": "2e3218c29d0d4fcc9d2c729ae25a3dd4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e3218c29d0d4fcc9d2c729ae25a3dd4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e3218c29d0d4fcc9d2c729ae25a3dd4"}}, "title": "Life with Parkinson\u2019s Disease During the COVID-19 Pandemic: The Pressure Is \u201cOFF\u201d", "authors": [{"family": "H\u00d8rmann Thomsen", "given": "Trine", "initials": "T"}, {"family": "Wallerstedt", "given": "Susanna M", "initials": "SM"}, {"family": "Winge", "given": "Kristian", "initials": "K"}, {"family": "Bergquist", "given": "Filip", "initials": "F"}], "type": "journal-article", "published": "2021-01-12", "journal": {"title": "JPD", "issn": "1877-7171", "volume": null, "issue": null, "pages": "1-5", "issn-l": null}, "abstract": "People with Parkinson's disease (PwP) have been suggested to be more vulnerable to negative psychological and psycho-social effects of the COVID-19 pandemic. Our aim was to assess the potential impact of the COVID-19 pandemic in PwP. A Danish/Swedish cohort of 67 PwP was analysed. Health-related quality of life (HRQL), depression, anxiety, apathy, sleep and motor symptom-scores were included in the analysis. Additionally, the Danish participants provided free-text descriptions of life during the pandemic. Overall, the participants reported significantly better HRQL during the COVID-19 period compared with before. Reduced social pressure may be part of the explanation. Despite worsened anxiety, night sleep improved.", "doi": "10.3233/jpd-202342", "pmid": "33459663", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-20T14:56:06.163Z", "modified": "2021-02-26T08:45:47.993Z"}, {"entity": "publication", "iuid": "07fb542a0f25476990091489eaf9e0db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07fb542a0f25476990091489eaf9e0db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07fb542a0f25476990091489eaf9e0db"}}, "title": "High Rates of COVID-19 Vaccine Hesitancy and Its Association with Conspiracy Beliefs: A Study in Jordan and Kuwait among Other Arab Countries", "authors": [{"family": "Sallam", "given": "Malik", "initials": "M"}, {"family": "Dababseh", "given": "Deema", "initials": "D"}, {"family": "Eid", "given": "Huda", "initials": "H"}, {"family": "Al-Mahzoum", "given": "Kholoud", "initials": "K"}, {"family": "Al-Haidar", "given": "Ayat", "initials": "A"}, {"family": "Taim", "given": "Duaa", "initials": "D"}, {"family": "Yaseen", "given": "Alaa", "initials": "A"}, {"family": "Ababneh", "given": "Nidaa A", "initials": "NA"}, {"family": "Bakri", "given": "Faris G", "initials": "FG"}, {"family": "Mahafzah", "given": "Azmi", "initials": "A"}], "type": "journal-article", "published": "2021-01-12", "journal": {"title": "Vaccines", "issn": "2076-393X", "issn-l": null, "volume": "9", "issue": "1", "pages": "42"}, "abstract": null, "doi": "10.3390/vaccines9010042", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-15T13:13:59.416Z", "modified": "2021-06-18T10:01:39.292Z"}, {"entity": "publication", "iuid": "87a9168f79af44dfa5c06f3be54a5e14", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87a9168f79af44dfa5c06f3be54a5e14.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87a9168f79af44dfa5c06f3be54a5e14"}}, "title": "Cytoplasmic short linear motifs in ACE2 and integrin \u03b23 link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy.", "authors": [{"family": "Kliche", "given": "Johanna", "initials": "J", "orcid": "0000-0003-3179-4635", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/18ffcca5dbaa45bcad0d1385df5d0c12.json"}}, {"family": "Kuss", "given": "Hanna", "initials": "H", "orcid": "0000-0001-8948-7035", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/395062f1a0fe486cbfc1d025fa60bdad.json"}}, {"family": "Ali", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-8858-6776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0515e4fd072741b0a01456320bbf73de.json"}}, {"family": "Ivarsson", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-7081-3846", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b3cf0504a1b476f906c4b3e22b05d5a.json"}}], "type": "journal article", "published": "2021-01-12", "journal": {"title": "Sci Signal", "issn": "1937-9145", "issn-l": null, "volume": "14", "issue": "665", "pages": null}, "abstract": "The spike protein of SARS-CoV-2 binds the angiotensin-converting enzyme 2 (ACE2) on the host cell surface and subsequently enters host cells through receptor-mediated endocytosis. Additional cell receptors may be directly or indirectly involved, including integrins. The cytoplasmic tails of ACE2 and integrins contain several predicted short linear motifs (SLiMs) that may facilitate internalization of the virus as well as its subsequent propagation through processes such as autophagy. Here, we measured the binding affinity of predicted interactions between SLiMs in the cytoplasmic tails of ACE2 and integrin \u03b23 with proteins that mediate endocytic trafficking and autophagy. We validated that a class I PDZ-binding motif mediated binding of ACE2 to the scaffolding proteins SNX27, NHERF3, and SHANK, and that a binding site for the clathrin adaptor AP2 \u03bc2 in ACE2 overlaps with a phospho-dependent binding site for the SH2 domains of Src family tyrosine kinases. Furthermore, we validated that an LC3-interacting region (LIR) in integrin \u03b23 bound to the ATG8 domains of the autophagy receptors MAP1LC3 and GABARAP in a manner enhanced by LIR-adjacent phosphorylation. Our results provide molecular links between cell receptors and mediators of endocytosis and autophagy that may facilitate viral entry and propagation.", "doi": "10.1126/scisignal.abf1117", "pmid": "33436498", "labels": {"Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7928716"}, {"db": "pii", "key": "14/665/eabf1117"}], "notes": [], "created": "2021-01-08T08:52:49.399Z", "modified": "2023-06-19T15:00:19.344Z"}, {"entity": "publication", "iuid": "7cea9ce7584b467692597202c1fba7d1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7cea9ce7584b467692597202c1fba7d1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7cea9ce7584b467692597202c1fba7d1"}}, "title": "CSF Biomarkers in Patients With COVID-19 and Neurologic Symptoms: A Case Series.", "authors": [{"family": "Ed\u00e9n", "given": "Arvid", "initials": "A"}, {"family": "Kanberg", "given": "Nelly", "initials": "N"}, {"family": "Gostner", "given": "Johanna", "initials": "J", "orcid": "0000-0003-1532-5177", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42618c3aa97e473581a66529c2a8b4b2.json"}}, {"family": "Fuchs", "given": "Dietmar", "initials": "D"}, {"family": "Hagberg", "given": "Lars", "initials": "L"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Price", "given": "Richard W", "initials": "RW"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "case reports", "published": "2021-01-12", "journal": {"title": "Neurology", "issn": "1526-632X", "issn-l": "0028-3878", "volume": "96", "issue": "2", "pages": "e294-e300"}, "abstract": "To explore whether hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and neurologic symptoms have evidence of CNS infection, inflammation, and injury using CSF biomarker measurements.\n\nWe assessed CSF SARS-CoV-2 RNA along with CSF biomarkers of intrathecal inflammation (CSF white blood cell count, neopterin, \u03b22-microglobulin, and immunoglobulin G index), blood-brain barrier integrity (albumin ratio), and axonal injury (CSF neurofilament light chain protein [NfL]) in 6 patients with moderate to severe coronavirus disease 2019 (COVID-19) and neurologic symptoms who had undergone a diagnostic lumbar puncture. Neurologic symptoms and signs included features of encephalopathies (4 of 6), suspected meningitis (1 of 6), and dysgeusia (1 of 6). SARS-CoV-2 infection was confirmed by real-time PCR analysis of nasopharyngeal swabs.\n\nSARS-CoV-2 RNA was detected in the plasma of 2 patients (cycle threshold [Ct] value 35.0-37.0) and in CSF at low levels (Ct 37.2, 38.0, 39.0) in 3 patients in 1 but not in a second real-time PCR assay. CSF neopterin (median 43.0 nmol/L) and \u03b22-microglobulin (median 3.1 mg/L) were increased in all. Median immunoglobulin G index (0.39), albumin ratio (5.35), and CSF white blood cell count (<3 cells/\u00b5L) were normal in all, while CSF NfL was elevated in 2 patients.\n\nOur results in patients with COVID-19 and neurologic symptoms suggest an unusual pattern of marked CSF inflammation in which soluble markers were increased but white cell response and other immunologic features typical of CNS viral infections were absent. While our initial hypothesis centered on CNS SARS-CoV-2 invasion, we could not convincingly detect SARS-CoV-2 as the underlying driver of CNS inflammation. These features distinguish COVID-19 CSF from other viral CNS infections and raise fundamental questions about the CNS pathobiology of SARS-CoV-2 infection.", "doi": "10.1212/WNL.0000000000010977", "pmid": "33004602", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "WNL.0000000000010977"}], "notes": [], "created": "2020-10-28T09:06:39.849Z", "modified": "2023-06-19T14:46:31.151Z"}, {"entity": "publication", "iuid": "aaef86b6c7a14c1abe87aa0aef4e82b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aaef86b6c7a14c1abe87aa0aef4e82b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aaef86b6c7a14c1abe87aa0aef4e82b1"}}, "title": "Stimulating the Resolution of Inflammation Through Omega-3 Polyunsaturated Fatty Acids in COVID-19: Rationale for the COVID-Omega-F Trial.", "authors": [{"family": "Arnardottir", "given": "Hildur", "initials": "H"}, {"family": "Pawelzik", "given": "Sven-Christian", "initials": "SC", "orcid": "0000-0001-8704-6607", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5249b23453a347a883217f7c90cfeb00.json"}}, {"family": "\u00d6hlund Wistbacka", "given": "Ulf", "initials": "U"}, {"family": "Artiach", "given": "Gonzalo", "initials": "G"}, {"family": "Hofmann", "given": "Robin", "initials": "R"}, {"family": "Reinholdsson", "given": "Ingalill", "initials": "I"}, {"family": "Braunschweig", "given": "Frieder", "initials": "F"}, {"family": "Tornvall", "given": "Per", "initials": "P"}, {"family": "Religa", "given": "Dorota", "initials": "D"}, {"family": "B\u00e4ck", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2021-01-11", "journal": {"title": "Front Physiol", "issn": "1664-042X", "volume": "11", "issue": null, "pages": "624657", "issn-l": null}, "abstract": "Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). SARS-CoV-2 triggers an immune response with local inflammation in the lung, which may extend to a systemic hyperinflammatory reaction. Excessive inflammation has been reported in severe cases with respiratory failure and cardiovascular complications. In addition to the release of cytokines, referred to as cytokine release syndrome or \"cytokine storm,\" increased pro-inflammatory lipid mediators derived from the omega-6 polyunsaturated fatty acid (PUFA) arachidonic acid may cause an \"eicosanoid storm,\" which contributes to the uncontrolled systemic inflammation. Specialized pro-resolving mediators, which are derived from omega-3 PUFA, limit inflammatory reactions by an active process called resolution of inflammation. Here, the rationale for omega-3 PUFA supplementation in COVID-19 patients is presented along with a brief overview of the study protocol for the trial \"Resolving Inflammatory Storm in COVID-19 Patients by Omega-3 Polyunsaturated Fatty Acids - A single-blind, randomized, placebo-controlled feasibility study\" (COVID-Omega-F). EudraCT: 2020-002293-28; clinicaltrials.gov: NCT04647604.", "doi": "10.3389/fphys.2020.624657", "pmid": "33505321", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC7830247"}, {"db": "ClinicalTrials.gov", "key": "NCT04647604"}], "notes": [], "created": "2021-01-29T15:12:20.798Z", "modified": "2023-06-19T15:19:23.375Z"}, {"entity": "publication", "iuid": "0ab1e98bc6c24f64ad568682517aee4f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ab1e98bc6c24f64ad568682517aee4f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ab1e98bc6c24f64ad568682517aee4f"}}, "title": "Impact on physical and mental health among medical personnel in Wuhan during COVID-19 outbreak: a cluster analysis.", "authors": [{"family": "Gao", "given": "Jing", "initials": "J"}, {"family": "Li", "given": "Jing", "initials": "J"}, {"family": "Han", "given": "Xia", "initials": "X"}, {"family": "Yuan", "given": "Yuan", "initials": "Y"}, {"family": "Li", "given": "Chuan-Xing", "initials": "CX"}, {"family": "Zhang", "given": "Dong-Quan", "initials": "DQ"}], "type": "journal article", "published": "2021-01-11", "journal": {"title": "Int J Med Sci", "issn": "1449-1907", "volume": "18", "issue": "5", "pages": "1185-1188", "issn-l": null}, "abstract": "Background: Increased stress among medical personnel had been reported in previous virus outbreaks. The novel coronavirus disease (COVID-19) emerged in December 2019, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). No qualitative assessment has yet described the physical and mental health conditions of frontline medical personnel in the COVID-19 outbreaks. Methods: Here, 251 frontline medical personnel involved in COVID-19 missions completed electronic questionnaires, consisting of 31 categorical variables related to their physical and mental health status, medical history and environmental conditions. We constructed a correlation amongst these variables through pairwise Kendall rank correlation coefficient test. Then, clusters of highly correlated variables were identified using the leading eigenvector. Finally, we used the network and clusters to clarify the correlations amongst variables. Results: This qualitative study identified the six clusters. Cluster 1 was characterized by skin allergy. Cluster 2 was predominantly associated with anxiety. Cluster 3 consisted mostly of respiratory symptoms. The participants in cluster 4 had medical history. Cluster 5 and cluster 6 were characterized by disinfection and demography, respectively. Finally, we revealed three major findings. First, more than 80% of medical personnel worry about COVID-19-related infection and experience newly appearing anxiety (56.2%), airway or heart symptoms (34.3%) and skin allergies (20.3%). Second, COVID-19-related worry significantly associates with all variables in the anxiety and respiratory symptom clusters. Third, new-onset skin allergies did not associate with either disinfection or anxiety, but did associate with a previous history of allergies. Conclusions: COVID-19-related worry leads to physical and mental health problems amongst medical personnel. Effective responses and interventions could relieve a series of new-onset physical and mental health problems.", "doi": "10.7150/ijms.51315", "pmid": "33526979", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijmsv18p1185"}, {"db": "pmc", "key": "PMC7847622"}], "notes": [], "created": "2021-02-04T18:21:47.061Z", "modified": "2021-02-26T08:46:59.832Z"}, {"entity": "publication", "iuid": "040cdb5e913f4417ba0f2d8f35bfc266", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/040cdb5e913f4417ba0f2d8f35bfc266.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/040cdb5e913f4417ba0f2d8f35bfc266"}}, "title": "Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection.", "authors": [{"family": "Monteil", "given": "Vanessa", "initials": "V", "orcid": "0000-0002-2652-5695", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8ba8a0b1af6423b9cba0fc4bb3177cd.json"}}, {"family": "Dyczynski", "given": "Matheus", "initials": "M", "orcid": "0000-0002-7650-3574", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/85f093ab4ac24580810b0ea22f1dd0c6.json"}}, {"family": "Lauschke", "given": "Volker M", "initials": "VM", "orcid": "0000-0002-1140-6204", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe2e21e55733492996018d1a5b037969.json"}}, {"family": "Kwon", "given": "Hyesoo", "initials": "H"}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G"}, {"family": "Youhanna", "given": "Sonia", "initials": "S", "orcid": "0000-0002-9376-8478", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b777b2409fb34cd0b0d154bf2aab5d5d.json"}}, {"family": "Zhang", "given": "Haibo", "initials": "H", "orcid": "0000-0002-1714-3038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d1fe0f99f8a74a87a4772166d46744de.json"}}, {"family": "Slutsky", "given": "Arthur S", "initials": "AS", "orcid": "0000-0002-6063-3876", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8f9a9cd065c74b71960c62e55caf6b58.json"}}, {"family": "Hurtado Del Pozo", "given": "Carmen", "initials": "C"}, {"family": "Horn", "given": "Moritz", "initials": "M", "orcid": "0000-0002-5324-7256", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a000f2fad24410281396504ca78b6d8.json"}}, {"family": "Montserrat", "given": "Nuria", "initials": "N", "orcid": "0000-0002-1603-1755", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d4cdae2b5b34dd798f73faa0a3aa391.json"}}, {"family": "Penninger", "given": "Josef M", "initials": "JM", "orcid": "0000-0002-8194-3777", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6e56aaa008524272bf252df804e06991.json"}}, {"family": "Mirazimi", "given": "Ali", "initials": "A", "orcid": "0000-0003-2371-6055", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0651be47429c4e5880a13b839d04fe1d.json"}}], "type": "journal article", "published": "2021-01-11", "journal": {"title": "EMBO Mol Med", "issn": "1757-4684", "issn-l": "1757-4676", "volume": "13", "issue": "1", "pages": "e13426"}, "abstract": "There is a critical need for safe and effective drugs for COVID-19. Only remdesivir has received authorization for COVID-19 and has been shown to improve outcomes but not decrease mortality. However, the dose of remdesivir is limited by hepatic and kidney toxicity. ACE2 is the critical cell surface receptor for SARS-CoV-2. Here, we investigated additive effect of combination therapy using remdesivir with recombinant soluble ACE2 (high/low dose) on Vero E6 and kidney organoids, targeting two different modalities of SARS-CoV-2 life cycle: cell entry via its receptor ACE2 and intracellular viral RNA replication. This combination treatment markedly improved their therapeutic windows against SARS-CoV-2 in both models. By using single amino-acid resolution screening in haploid ES cells, we report a singular critical pathway required for remdesivir toxicity, namely, Adenylate Kinase 2. The data provided here demonstrate that combining two therapeutic modalities with different targets, common strategy in HIV treatment, exhibit strong additive effects at sub-toxic concentrations. Our data lay the groundwork for the study of combinatorial regimens in future COVID-19 clinical trials.", "doi": "10.15252/emmm.202013426", "pmid": "33179852", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: H2020": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pmc", "key": "PMC7799356"}], "notes": [], "created": "2020-11-19T19:45:22.452Z", "modified": "2023-06-19T14:43:00.181Z"}, {"entity": "publication", "iuid": "bc16a7b8aa2048cbbe80b22f956dbe5f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bc16a7b8aa2048cbbe80b22f956dbe5f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bc16a7b8aa2048cbbe80b22f956dbe5f"}}, "title": "[Temporal variations in excess mortality during phase 1 and phase 2 of the COVID-19 epidemic in Italy].", "authors": [{"family": "Michelozzi", "given": "Paola", "initials": "P"}, {"family": "De' Donato", "given": "Francesca", "initials": "F"}, {"family": "De Sario", "given": "Manuela", "initials": "M"}, {"family": "Stortichini", "given": "Matteo", "initials": "M"}, {"family": "Stafoggia", "given": "Massimo", "initials": "M"}, {"family": "Niccioli", "given": "Fiammetta", "initials": "F"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Boros", "given": "Stefano", "initials": "S"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Urdiales", "given": "Alberto Mateo", "initials": "AM"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Rossi", "given": "Pasqualino", "initials": "P"}, {"family": "Rezza", "given": "Giovanni", "initials": "G"}, {"family": "Costa", "given": "Giuseppe", "initials": "G"}, {"family": "Davoli", "given": "Marina", "initials": "M"}], "type": "journal article", "published": "2021-01-09", "journal": {"title": "Epidemiol Prev", "issn": "1120-9763", "issn-l": null, "volume": "44", "issue": "5-6 Suppl 2", "pages": "236-243"}, "abstract": "to assess the temporal variation in excess total mortality and the portion of excess explained by COVID-19 deaths by geographical area, gender, and age during the COVID-19 epidemic.\r\n\r\ndescriptive analysis of temporal variations of total excess deaths and COVID-19 deaths in the phase 1 and phase 2 of the epidemic in Italy.\r\n\r\n12 Northern cities and 20 Central-Southern cities from December 2019 to June 2020: daily mortality from the National Surveillance System of Daily Mortality (SiSMG) and COVID-19 deaths from the integrated COVID-19 surveillance system.\r\n\r\ntotal mortality excess and COVID-19 deaths, defined as deaths in microbiologically confirmed cases of SARS-CoV-2, by gender and age groups.\r\n\r\nthe largest excess mortality was observed in the North and during the first phase of the epidemic. The portion of excess mortality explained by COVID-19 decreases with age, decreasing to 51% among the very old (>=85 years). In phase 2 (until June 2020), the impact was more contained and totally attributable to COVID-19 deaths and this suggests an effectiveness of social distancing measures.\r\n\r\nmortality surveillance is a sensible information basis for the monitoring of health impact of the different phases of the epidemic and supporting decision making at the local and national level on containment measures to put in place in coming months.", "doi": "10.19191/EP20.5-6.S2.123", "pmid": "33412815", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "5208"}], "notes": [], "created": "2021-01-22T09:21:41.132Z", "modified": "2021-02-26T08:47:00.183Z"}, {"entity": "publication", "iuid": "67723ab246aa40aeb3fb9fa0f012aa56", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/67723ab246aa40aeb3fb9fa0f012aa56.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/67723ab246aa40aeb3fb9fa0f012aa56"}}, "title": "[Integrated Surveillance in Italy: outputs and related activities].", "authors": [{"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Urdiales", "given": "Alberto Mateo", "initials": "AM"}, {"family": "Vescio", "given": "Maria Fenicia", "initials": "MF"}, {"family": "Rota", "given": "Maria Cristina", "initials": "MC"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Boros", "given": "Stefano", "initials": "S"}, {"family": "Bellino", "given": "Stefania", "initials": "S"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Ciervo", "given": "Alessandra", "initials": "A"}, {"family": "Punzo", "given": "Ornella", "initials": "O"}, {"family": "Filia", "given": "Antonietta", "initials": "A"}, {"family": "Tallon", "given": "Marco", "initials": "M"}, {"family": "Di Benedetto", "given": "Corrado", "initials": "C"}, {"family": "Spuri", "given": "Matteo", "initials": "M"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Bella", "given": "Antonella", "initials": "A"}, {"family": "Gruppo Referenti regionali della Sorveglianza Integrata COVID-19", "given": "", "initials": ""}], "type": "journal article", "published": "2021-01-09", "journal": {"title": "Epidemiol Prev", "issn": "1120-9763", "volume": "44", "issue": "5-6 Suppl 2", "pages": "70-80", "issn-l": null}, "abstract": "to describe the integrated surveillance system of COVID-19 in Italy, to illustrate the outputs used to return epidemiological information on the spread of the epidemic to the competent public health bodies and to the Italian population, and to describe how the surveillance data contributes to the ongoing weekly regional monitoring and risk assessment system.\n\nthe COVID-19 integrated surveillance system is the result of a close and continuous collaboration between the Italian National Institute of Health (ISS), the Italian Ministry of Health, and the regional and local health authorities. Through a web platform, it collects individual data of laboratory confirmed cases of SARS-CoV-2 infection and gathers information on their residence, laboratory diagnosis, hospitalisation, clinical status, risk factors, and outcome. Results, for different levels of aggregation and risk categories, are published daily and weekly on the ISS website, and made available to national and regional public health authorities; these results contribute one of the information sources of the regional monitoring and risk assessment system.\n\nthe COVID-19 integrated surveillance system monitors the space-time distribution of cases and their characteristics. Indicators used in the weekly regional monitoring and risk assessment system include process indicators on completeness and results indicators on weekly trends of newly diagnosed cases per Region.\n\nthe outputs of the integrated surveillance system for COVID-19 provide timely information to health authorities and to the general population on the evolution of the epidemic in Italy. They also contribute to the continuous re-assessment of risk related to transmission and impact of the epidemic thus contributing to the management of COVID-19 in Italy.", "doi": "10.19191/EP20.5-6.S2.105", "pmid": "33412796", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "5088"}], "notes": [], "created": "2021-01-22T09:22:48.456Z", "modified": "2021-02-26T08:47:00.008Z"}, {"entity": "publication", "iuid": "c8b44880a5bf4cc19fcf261c46c33ab8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c8b44880a5bf4cc19fcf261c46c33ab8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c8b44880a5bf4cc19fcf261c46c33ab8"}}, "title": "Rituximab for the treatment of multiple sclerosis: a review.", "authors": [{"family": "Chisari", "given": "Clara Grazia", "initials": "CG"}, {"family": "Sgarlata", "given": "Eleonora", "initials": "E"}, {"family": "Arena", "given": "Sebastiano", "initials": "S"}, {"family": "Toscano", "given": "Simona", "initials": "S"}, {"family": "Luca", "given": "Maria", "initials": "M"}, {"family": "Patti", "given": "Francesco", "initials": "F"}], "type": "journal article", "published": "2021-01-08", "journal": {"title": "J Neurol", "issn": "1432-1459", "volume": null, "issue": null, "issn-l": null}, "abstract": "In the last decades, evidence suggesting the direct or indirect involvement of B cells on multiple sclerosis (MS) pathogenesis has accumulated. The increased amount of data on the efficacy and safety of B-cell-depleting therapies from several studies has suggested the addition of these drugs as treatment options to the current armamentarium of disease modifying therapies (DMTs) for MS. Particularly, rituximab (RTX), a chimeric monoclonal antibody directed at CD20 positive B lymphocytes resulting in cell-mediated apoptosis, has been demonstrated to reduce inflammatory activity, incidence of relapses and new brain lesions on magnetic resonance imaging (MRI) in patients with relapsing-remitting MS (RRMS). Additional evidence also demonstrated that patients with progressive MS (PMS) may benefit from RTX, which also showed to be well tolerated, with acceptable safety risks and favorable cost-effectiveness profile.Despite these encouraging results, RTX is currently approved for non-Hodgkin's lymphoma, chronic lymphocytic leukemia, several forms of vasculitis and rheumatoid arthritis, while it can only be administered off-label for MS treatment. Between Northern European countries exist different rules for using not licensed drug for treating MS. The Sweden MS register reports a high rate (53.5%) of off-label RTX prescriptions in relation to other annually started DMTs to treat MS patients, while Danish and Norwegian neurologists have to use other anti-CD20 drugs, as ocrelizumab, in most of the cases.In this paper, we review the pharmacokinetics, pharmacodynamics, clinical efficacy, safety profile and cost effectiveness aspects of RTX for the treatment of MS. Particularly, with the approval of new anti-CD20 DMTs, the recent worldwide COVID-19 emergency and the possible increased risk of infection with this class of drugs, this review sheds light on the use of RTX as an alternative treatment option for MS management, while commenting the gaps of knowledge regarding this drug.", "doi": "10.1007/s00415-020-10362-z", "pmid": "33416999", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00415-020-10362-z"}], "notes": [], "created": "2021-01-10T18:21:47.460Z", "modified": "2021-01-10T18:21:47.469Z"}, {"entity": "publication", "iuid": "4977214db52547d5837a73d23539ceee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4977214db52547d5837a73d23539ceee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4977214db52547d5837a73d23539ceee"}}, "title": "Mental Distress and Human Rights Violations During COVID-19: A Rapid Review of the Evidence Informing Rights, Mental Health Needs, and Public Policy Around Vulnerable Populations.", "authors": [{"family": "Rahman", "given": "Muhammad", "initials": "M"}, {"family": "Ahmed", "given": "Rabab", "initials": "R"}, {"family": "Moitra", "given": "Modhurima", "initials": "M"}, {"family": "Damschroder", "given": "Laura", "initials": "L"}, {"family": "Brownson", "given": "Ross", "initials": "R"}, {"family": "Chorpita", "given": "Bruce", "initials": "B"}, {"family": "Idele", "given": "Priscilla", "initials": "P"}, {"family": "Gohar", "given": "Fatima", "initials": "F"}, {"family": "Huang", "given": "Keng Yen", "initials": "KY"}, {"family": "Saxena", "given": "Shekhar", "initials": "S"}, {"family": "Lai", "given": "Joanna", "initials": "J"}, {"family": "Peterson", "given": "Stefan Swartling", "initials": "SS"}, {"family": "Harper", "given": "Gary", "initials": "G"}, {"family": "McKay", "given": "Mary", "initials": "M"}, {"family": "Amugune", "given": "Beatrice", "initials": "B"}, {"family": "Esho", "given": "Tammary", "initials": "T"}, {"family": "Ronen", "given": "Keshet", "initials": "K"}, {"family": "Othieno", "given": "Caleb", "initials": "C"}, {"family": "Kumar", "given": "Manasi", "initials": "M"}], "type": "journal article", "published": "2021-01-08", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "11", "issue": null, "pages": "603875", "issn-l": "1664-0640"}, "abstract": "Background: COVID-19 prevention and mitigation efforts were abrupt and challenging for most countries with the protracted lockdown straining socioeconomic activities. Marginalized groups and individuals are particularly vulnerable to adverse effects of the pandemic such as human rights abuses and violations which can lead to psychological distress. In this review, we focus on mental distress and disturbances that have emanated due to human rights restrictions and violations amidst the pandemic. We underscore how mental health is both directly impacted by the force of pandemic and by prevention and mitigation structures put in place to combat the disease. Methods: We conducted a review of relevant studies examining human rights violations in COVID-19 response, with a focus on vulnerable populations, and its association with mental health and psychological well-being. We searched PubMed and Embase databases for studies between December 2019 to July 2020. Three reviewers evaluated the eligibility criteria and extracted data. Results: Twenty-four studies were included in the systematic inquiry reporting on distress due to human rights violations. Unanimously, the studies found vulnerable populations to be at a high risk for mental distress. Limited mobility rights disproportionately harmed psychiatric patients, low-income individuals, and minorities who were at higher risk for self-harm and worsening mental health. Healthcare workers suffered negative mental health consequences due to stigma and lack of personal protective equipment and stigma. Other vulnerable groups such as the elderly, children, and refugees also experienced negative consequences. Conclusions: This review emphasizes the need to uphold human rights and address long term mental health needs of populations that have suffered disproportionately during the pandemic. Countries can embed a proactive psychosocial response to medical management as well as in existing prevention strategies. International human rights guidelines are useful in this direction but an emphasis should be placed on strengthening rights informed psychosocial response with specific strategies to enhance mental health in the long-term. We underscore that various fundamental human rights are interdependent and therefore undermining one leads to a poor impact on the others. We strongly recommend global efforts toward focusing both on minimizing fatalities, protecting human rights, and promoting long term mental well-being.", "doi": "10.3389/fpsyt.2020.603875", "pmid": "33488426", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7820171"}], "notes": [], "created": "2021-02-04T18:39:24.005Z", "modified": "2021-02-04T18:39:33.273Z"}, {"entity": "publication", "iuid": "c0aa971aae314be58621c5bea009cf62", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c0aa971aae314be58621c5bea009cf62.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c0aa971aae314be58621c5bea009cf62"}}, "title": "Inherent random fluctuations in COVID-19 outbreaks may explain rapid growth of new mutated virus variants", "authors": [{"family": "Bodin", "given": "Kenneth", "initials": "K"}, {"family": "Rocklov", "given": "Joacim", "initials": "J"}], "type": "posted-content", "published": "2021-01-08", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.01.07.21249353", "pmid": null, "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-10T18:36:49.125Z", "modified": "2021-02-26T08:45:48.640Z"}, {"entity": "publication", "iuid": "e3bd61a03fcf42a7871602b18648b374", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3bd61a03fcf42a7871602b18648b374.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3bd61a03fcf42a7871602b18648b374"}}, "title": "Epidemiological characteristics of COVID-19 cases in non-Italian nationals notified to the Italian surveillance system.", "authors": [{"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Mateo-Urdiales", "given": "Alberto", "initials": "A"}, {"family": "Andrianou", "given": "Xanthi", "initials": "X"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Bellino", "given": "Stefania", "initials": "S"}, {"family": "Rota", "given": "Maria C", "initials": "MC"}, {"family": "Boros", "given": "Stefano", "initials": "S"}, {"family": "Vescio", "given": "Maria F", "initials": "MF"}, {"family": "D'Ancona", "given": "Fortunato P", "initials": "FP"}, {"family": "Siddu", "given": "Andrea", "initials": "A"}, {"family": "Punzo", "given": "Ornella", "initials": "O"}, {"family": "Filia", "given": "Antonietta", "initials": "A"}, {"family": "Brusaferro", "given": "Silvio", "initials": "S"}, {"family": "Rezza", "given": "Giovanni", "initials": "G"}, {"family": "Dente", "given": "Maria G", "initials": "MG"}, {"family": "Declich", "given": "Silvia", "initials": "S"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "group", "given": "COVID-19 working", "initials": "Cw"}, {"family": ",", "given": "", "initials": ""}], "type": "journal article", "published": "2021-01-08", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": null, "issue": null, "pages": null}, "abstract": "International literature suggests that disadvantaged groups are at higher risk of morbidity and mortality from SARS-CoV-2 infection due to poorer living/working conditions and barriers to healthcare access. Yet, to date, there is no evidence of this disproportionate impact on non-national individuals, including economic migrants, short-term travellers, and refugees.\r\n\r\nWe analysed data from the Italian surveillance system of all COVID-19 laboratory-confirmed cases tested positive from the beginning of the outbreak (20th of February) to the 19th of July 2020. We used multilevel negative-binomial regression models to compare the case-fatality and the rate of admission to hospital and intensive care unit (ICU) between Italian and non-Italian nationals. The analysis was adjusted for differences in demographic characteristics, pre-existing comorbidities, and period of diagnosis.\r\n\r\nWe analysed 213,180 COVID-19 cases, including 15,974 (7.5%) non-Italian nationals. We found that, compared to Italian cases, non-Italian cases were diagnosed at a later date and were more likely to be hospitalised [(adjusted rate ratio (ARR)=1.39, 95% confidence interval (CI): 1.33-1.44)] and admitted to ICU (ARR = 1.19, 95% CI: 1.07-1.32), with differences being more pronounced in those coming from countries with lower HDI. We also observed an increased risk of death in non-Italian cases from low-HDI countries (ARR = 1.32, 95% CI: 1.01-1.75).\r\n\r\nA delayed diagnosis in non-Italian cases could explain their worse outcomes compared to Italian cases. Ensuring early access to diagnosis and treatment to non-Italians could facilitate the control of SARS-CoV-2 transmission and improve health outcomes in all people living in Italy, regardless of nationality.", "doi": "10.1093/eurpub/ckaa249", "pmid": "33416859", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "6070147"}], "notes": [], "created": "2021-01-10T18:22:12.486Z", "modified": "2021-06-18T09:27:00.582Z"}, {"entity": "publication", "iuid": "f788045b36924a1fbc1785be50402e62", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f788045b36924a1fbc1785be50402e62.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f788045b36924a1fbc1785be50402e62"}}, "title": "Competing Health Risks Associated with the COVID-19 Pandemic and Response: A Scoping Review", "authors": [{"family": "Baral", "given": "Stefan", "initials": "S"}, {"family": "Rao", "given": "Amrita", "initials": "A"}, {"family": "Twahirwa Rwema", "given": "Jean Olivier", "initials": "JO"}, {"family": "Lyons", "given": "Carrie", "initials": "C"}, {"family": "Cevik", "given": "Muge", "initials": "M"}, {"family": "K\u00e5gesten", "given": "Anna E", "initials": "AE"}, {"family": "Diouf", "given": "Daouda", "initials": "D"}, {"family": "Sohn", "given": "Annette H", "initials": "AH"}, {"family": "Phaswana-Mafuya", "given": "Refilwe", "initials": "R"}, {"family": "Kamarulzaman", "given": "Adeeba", "initials": "A"}, {"family": "Millett", "given": "Gregorio", "initials": "G"}, {"family": "Marcus", "given": "Julia L", "initials": "JL"}, {"family": "Mishra", "given": "Sharmistha", "initials": "S"}], "type": "posted-content", "published": "2021-01-08", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2021.01.07.21249419", "pmid": null, "labels": {"Type: Review": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2021-01-29T17:36:34.092Z", "modified": "2021-06-09T19:28:34.774Z"}, {"entity": "publication", "iuid": "02eaf5bdae9e4092b8b24cd7533ece27", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02eaf5bdae9e4092b8b24cd7533ece27.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02eaf5bdae9e4092b8b24cd7533ece27"}}, "title": "COVID-19 epidemic in Libya.", "authors": [{"family": "Bredan", "given": "Amin", "initials": "A"}, {"family": "Bakoush", "given": "Omran", "initials": "O"}], "type": "journal article", "published": "2021-01-08", "journal": {"title": "Libyan J Med", "issn": "1819-6357", "issn-l": null, "volume": "16", "issue": "1", "pages": "1871798"}, "abstract": "The first case of COVID-19 was identified in Libya on 24/3/2020, and about 2 months later, the number of reported COVID-19 cases started to increase notably. The outbreak was first prominent in the southern region (Sabha) and then spread to the western and eastern parts of Libya. By 24/12/2020, the reported total number of deaths from COVID-19 reached 1415. There seems to be no published data on the size of the epidemic in Libya. Here, we estimated the number of Libyans exposed to COVID-19 by using a COVID-19 mortality adjusted mathematical model for the spread of infectious diseases. We estimated that 14-20% of the Libyan population have been exposed to the COVID-19 pandemic. Thus, the risk of spread of COVID-19 infections during the coming months is high, and a considerable number of Libyans, particularly the elderly and people with chronic diseases, should be protected against COVID-19 infection. This is particularly urgent in the light of unofficial reports that the relevant healthcare facilities are under extreme stress.", "doi": "10.1080/19932820.2021.1871798", "pmid": "33407008", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-07T17:09:02.169Z", "modified": "2021-06-18T09:54:28.522Z"}, {"entity": "publication", "iuid": "5ef2c75ecf0643128f220f1ae1ce1bdf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5ef2c75ecf0643128f220f1ae1ce1bdf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5ef2c75ecf0643128f220f1ae1ce1bdf"}}, "title": "Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma", "authors": [{"family": "Kermani", "given": "Nazanin Zounemat", "initials": "NZ"}, {"family": "None", "given": "", "initials": ""}, {"family": "Song", "given": "Woo Jung", "initials": "WJ"}, {"family": "Badi", "given": "Yusef", "initials": "Y"}, {"family": "Versi", "given": "Ali", "initials": "A"}, {"family": "Guo", "given": "Yike", "initials": "Y"}, {"family": "Sun", "given": "Kai", "initials": "K"}, {"family": "Bhavsar", "given": "Pank", "initials": "P"}, {"family": "Howarth", "given": "Peter", "initials": "P"}, {"family": "Dahlen", "given": "Sven Erik", "initials": "SE"}, {"family": "Sterk", "given": "Peter J", "initials": "PJ"}, {"family": "Djukanovic", "given": "Ratko", "initials": "R"}, {"family": "Adcock", "given": "Ian M", "initials": "IM"}, {"family": "Chung", "given": "Kian Fan", "initials": "KF"}], "type": "journal-article", "published": "2021-01-07", "journal": {"title": "Respir Res", "issn": "1465-993X", "issn-l": "1465-9921", "volume": "22", "issue": "1", "pages": "101876"}, "abstract": "Bats are reservoirs for a large number of viruses which have potential to cause major human disease outbreaks, including the current coronavirus disease 2019 (COVID-19) pandemic. Major efforts are underway to understand bat immune response to viruses, whereas much less is known about their immune responses to bacteria. In this study, MR1-restricted T (MR1T) cells were detected through the use of MR1 tetramers in circulation and tissues of Pteropus alecto (Pa) bats. Pa MR1T cells exhibited weak responses to MR1-presented microbial metabolites at resting state. However, following priming with MR1-presented agonist they proliferated, upregulated critical transcription factors and cytolytic proteins, and gained transient expression of Th1/17-related cytokines and antibacterial cytotoxicity. Collectively, these findings show that the Pa bat immune system encompasses an abundant and functionally conserved population of MR1T cells with mucosal-associated invariant T-like characteristics, suggesting that MR1 and MR1T cells also play a significant role in bat immune defense.", "doi": "10.1186/s12931-020-01605-8", "pmid": "33344919", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-10T18:25:02.052Z", "modified": "2021-02-26T08:45:48.250Z"}, {"entity": "publication", "iuid": "fd17970ab9a34ca4a39b8a169f6a9f15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fd17970ab9a34ca4a39b8a169f6a9f15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fd17970ab9a34ca4a39b8a169f6a9f15"}}, "title": "Parental experiences of homeschooling during the COVID-19 pandemic: differences between seven European countries and between children with and without mental health conditions", "authors": [{"family": "Thorell", "given": "Lisa B", "initials": "LB"}, {"family": "Skoglund", "given": "Charlotte", "initials": "C"}, {"family": "de la Pe\u00f1a", "given": "Almudena Gim\u00e9nez", "initials": "AG"}, {"family": "Baeyens", "given": "Dieter", "initials": "D"}, {"family": "Fuermaier", "given": "Anselm B M", "initials": "ABM"}, {"family": "Groom", "given": "Madeleine J", "initials": "MJ"}, {"family": "Mammarella", "given": "Irene C", "initials": "IC"}, {"family": "van der Oord", "given": "Saskia", "initials": "S"}, {"family": "van den Hoofdakker", "given": "Barbara J", "initials": "BJ"}, {"family": "Luman", "given": "Marjolein", "initials": "M"}, {"family": "de Miranda", "given": "D\u00e9bora Marques", "initials": "DM"}, {"family": "Siu", "given": "Angela F Y", "initials": "AFY"}, {"family": "Steinmayr", "given": "Ricarda", "initials": "R"}, {"family": "Idrees", "given": "Iman", "initials": "I"}, {"family": "Soares", "given": "Lorrayne Stephane", "initials": "LS"}, {"family": "S\u00f6rlin", "given": "Matilda", "initials": "M"}, {"family": "Luque", "given": "Juan Luis", "initials": "JL"}, {"family": "Moscardino", "given": "Ughetta M", "initials": "UM"}, {"family": "Roch", "given": "Maja", "initials": "M"}, {"family": "Crisci", "given": "Giulia", "initials": "G"}, {"family": "Christiansen", "given": "Hanna", "initials": "H"}], "type": "journal-article", "published": "2021-01-07", "journal": {"title": "Eur Child Adolesc Psychiatry", "issn": "1018-8827", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1007/s00787-020-01706-1", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-10T18:23:30.328Z", "modified": "2021-06-18T09:16:00.365Z"}, {"entity": "publication", "iuid": "d6033efeda044768b62aab15cc8406a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d6033efeda044768b62aab15cc8406a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d6033efeda044768b62aab15cc8406a0"}}, "title": "Minimal transmission of SARS-CoV-2 from paediatric COVID-19 cases in primary schools, Norway, August to November 2020", "authors": [{"family": "Brandal", "given": "Lin T", "initials": "LT"}, {"family": "Ofitserova", "given": "Trine S", "initials": "TS"}, {"family": "Meijerink", "given": "Hinta", "initials": "H"}, {"family": "Rykkvin", "given": "Rikard", "initials": "R"}, {"family": "Lund", "given": "Hilde M", "initials": "HM"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "Greve-Isdahl", "given": "Margrethe", "initials": "M"}, {"family": "Bragstad", "given": "Karoline", "initials": "K"}, {"family": "Nyg\u00e5rd", "given": "Karin", "initials": "K"}, {"family": "Winje", "given": "Brita A", "initials": "BA"}], "type": "journal-article", "published": "2021-01-07", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "26", "issue": "1", "pages": null}, "abstract": null, "doi": "10.2807/1560-7917.es.2020.26.1.2002011", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "NA", "key": "Available in paper; Detection of SARS-CoV-2 in saliva samples from paediatric COVID-19 index cases and their school contacts", "description": null}], "notes": [], "created": "2021-01-10T18:24:13.864Z", "modified": "2021-06-18T09:43:42.157Z"}, {"entity": "publication", "iuid": "517a97de636c40abaceadf785b375e76", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/517a97de636c40abaceadf785b375e76.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/517a97de636c40abaceadf785b375e76"}}, "title": "Covid-19 FAQ's in Paediatric and Congenital Cardiology - AEPC position paper.", "authors": [{"family": "Sendzikaite", "given": "Skaiste", "initials": "S"}, {"family": "Heying", "given": "Ruth", "initials": "R"}, {"family": "Milanesi", "given": "Ornella", "initials": "O"}, {"family": "Hanseus", "given": "Katarina", "initials": "K"}, {"family": "Michel-Behnke", "given": "Ina", "initials": "I"}], "type": "journal article", "published": "2021-01-07", "journal": {"title": "Cardiol Young", "issn": "1467-1107", "volume": null, "issue": null, "pages": "1-21", "issn-l": null}, "abstract": "The Covid-19 pandemic has had a huge influence in almost all areas of life, affecting societies, economics and health care systems worldwide. The paediatric cardiology community is no exception. As the challenging battle with Covid-19 continues, professionals from the Association for the European Paediatric and Congenital Cardiology (AEPC) receive many questions regarding Covid-19 in a Paediatric and Congenital Cardiology setting. The aim of this paper is to present the AEPC position on frequently asked questions based on the most recent scientific data, as well as to frame a discussion on how to take care of our patients during this unprecedented crisis. As the times are changing quickly and information regarding Covid-19 is very dynamic, continuous collection of evidence will help guide constructive decision-making.", "doi": "10.1017/S1047951120005028", "pmid": "33407975", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1047951120005028"}], "notes": [], "created": "2021-01-07T17:07:20.941Z", "modified": "2021-01-10T18:28:15.315Z"}, {"entity": "publication", "iuid": "c7e1e3e4c7c44e44bc461e8198ec1610", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7e1e3e4c7c44e44bc461e8198ec1610.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7e1e3e4c7c44e44bc461e8198ec1610"}}, "title": "Prehospital identification of Covid-19: an observational study.", "authors": [{"family": "Spangler", "given": "Douglas", "initials": "D"}, {"family": "Blomberg", "given": "Hans", "initials": "H"}, {"family": "Smekal", "given": "David", "initials": "D"}], "type": "journal article", "published": "2021-01-06", "journal": {"title": "Scand J Trauma Resusc Emerg Med", "issn": "1757-7241", "volume": "29", "issue": "1", "pages": "3", "issn-l": "1757-7241"}, "abstract": "The novel coronavirus disease 2019 (Covid-19) pandemic has affected prehospital care systems across the world, but the prehospital presentation of affected patients and the extent to which prehospital care providers are able to identify them is not well characterized. In this study, we describe the presentation of Covid-19 patients in a Swedish prehospital care system, and asses the predictive value of Covid-19 suspicion as documented by dispatch and ambulance nurses.\n\nData for all patients with dispatch, ambulance, and hospital records between January 1-August 31, 2020 were extracted. A descriptive statistical analysis of patients with and without hospital-confirmed Covid-19 was performed. In a subset of records beginning from April 14, we assessed the sensitivity and specificity of documented Covid-19 suspicion in dispatch and ambulance patient care records.\n\nA total of 11,894 prehospital records were included, of which 481 had a primary hospital diagnosis code related to-, or positive test results for Covid-19. Covid-19-positive patients had considerably worse outcomes than patients with negative test results, with 30-day mortality rates of 24% vs 11%, but lower levels of prehospital acuity (e.g. emergent transport rates of 14% vs 22%). About half (46%) of Covid-19-positive patients presented to dispatchers with primary complaints typically associated with Covid-19. Six thousand seven hundred seventy-six records were included in the assessment of predictive value. Sensitivity was 76% (95% CI 71-80) and 82% (78-86) for dispatch and ambulance suspicion respectively, while specificities were 86% (85-87) and 78% (77-79).\n\nWhile prehospital suspicion was strongly indicative of hospital-confirmed Covid-19, based on the sensitivity identified in this study, prehospital suspicion should not be relied upon as a single factor to rule out the need for isolation precautions. The data provided may be used to develop improved guidelines for identifying Covid-19 patients in the prehospital setting.", "doi": "10.1186/s13049-020-00826-6", "pmid": "33407750", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-07T17:08:24.708Z", "modified": "2021-02-26T08:45:48.690Z"}, {"entity": "publication", "iuid": "9743266e3b1c4018b98b4ba412d671cd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9743266e3b1c4018b98b4ba412d671cd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9743266e3b1c4018b98b4ba412d671cd"}}, "title": "Biosocial Strategies to Address the Socioeconomic Determinants and Consequences of the TB and COVID-19 Pandemics.", "authors": [{"family": "Pedrazzoli", "given": "Debora", "initials": "D"}, {"family": "Wingfield", "given": "Tom", "initials": "T"}], "type": "journal article", "published": "2021-01-06", "journal": {"title": "Am J Trop Med Hyg", "issn": "1476-1645", "issn-l": "0002-9637", "volume": null, "issue": null, "pages": null}, "abstract": "Biosocial Strategies to Address the Socioeconomic Determinants and Consequences of the TB and COVID-19 Syndemics.", "doi": "10.4269/ajtmh.20-1641", "pmid": "33410391", "labels": {"Type: Other": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-08T07:18:14.824Z", "modified": "2021-06-18T09:11:25.810Z"}, {"entity": "publication", "iuid": "7d7c1595811b45f09fec445a255d13db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d7c1595811b45f09fec445a255d13db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d7c1595811b45f09fec445a255d13db"}}, "title": "The challenges of COVID-19 testing in Africa: the Ethiopian experience.", "authors": [{"family": "Mulu", "given": "Andargachew", "initials": "A"}, {"family": "Bekele", "given": "Amsalu", "initials": "A"}, {"family": "Abdissa", "given": "Alemseged", "initials": "A"}, {"family": "Balcha", "given": "Taye Tolera", "initials": "TT"}, {"family": "Habtamu", "given": "Meseret", "initials": "M"}, {"family": "Mihret", "given": "Adane", "initials": "A"}, {"family": "Alemayehu", "given": "Dawit Hailu", "initials": "DH"}, {"family": "Beyene", "given": "Getachew Tesfaye", "initials": "GT"}, {"family": "Bayih", "given": "Abebe Genetu", "initials": "AG"}], "type": "journal article", "published": "2021-01-05", "journal": {"title": "Pan Afr Med J", "issn": "1937-8688", "issn-l": null, "volume": "38", "issue": null, "pages": "6"}, "abstract": "Novel coronavirus disease (COVID-19) is spreading rapidly and creating a huge economic, social and public health challenge worldwide. Although currently an effective vaccine is ready, its distribution is limited, and hence the only currently available lever to reduce transmission is to identify and isolate individuals who are contagious. Thus, testing for SARS CoV-2 has a paramount importance. However, testing in many African countries including Ethiopia has multidimensional growing challenges. Here, we tried to identify, categorize and summarize the challenges of COVID-19 testing in Africa from Ethiopian experience.", "doi": "10.11604/pamj.2021.38.6.26902", "pmid": "33520075", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "PAMJ-38-6"}, {"db": "pmc", "key": "PMC7825374"}], "notes": [], "created": "2021-02-04T18:37:05.674Z", "modified": "2021-06-18T08:50:19.957Z"}, {"entity": "publication", "iuid": "7de895fcacdf46a48f1977a21c2c05d1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7de895fcacdf46a48f1977a21c2c05d1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7de895fcacdf46a48f1977a21c2c05d1"}}, "title": "Recovery scenario and immunity in COVID-19 disease: A new strategy to predict the potential of reinfection.", "authors": [{"family": "Khoshkam", "given": "Zahra", "initials": "Z"}, {"family": "Aftabi", "given": "Younes", "initials": "Y"}, {"family": "Stenvinkel", "given": "Peter", "initials": "P"}, {"family": "Paige Lawrence", "given": "B", "initials": "B"}, {"family": "Rezaei", "given": "Mehran Habibi", "initials": "MH"}, {"family": "Ichihara", "given": "Gaku", "initials": "G"}, {"family": "Fereidouni", "given": "Sasan", "initials": "S"}], "type": "journal article", "published": "2021-01-05", "journal": {"title": "J Adv Res", "issn": "2090-1232", "volume": null, "issue": null, "issn-l": null}, "abstract": "The recent ongoing outbreak of coronavirus disease 2019 (COVID-19), still is an unsolved problem with a growing rate of infected cases and mortality worldwide. The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is targeting the angiotensin-converting enzyme 2 (ACE2) receptor and mostly causes a respiratory illness. Although acquired and resistance immunity is one of the most important aspects of alleviating the trend of the current pandemic; however, there is still a big gap of knowledge regarding the infection process, immunopathogenesis, recovery, and reinfection.\n\nTo answer the questions regarding \"the potential and probability of reinfection in COVID-19 infected cases\" or \"the efficiency and duration of SARS-CoV-2 infection-induced immunity against reinfection\" we critically evaluated the current reports on SARS-CoV-2 immunity and reinfection with special emphasis on comparative studies using animal models that generalize their finding about protection and reinfection. Also, the contribution of humoral immunity in the process of COVID-19 recovery and the role of ACE2 in virus infectivity and pathogenesis has been discussed. Furthermore, innate and cellular immunity and inflammatory responses in the disease and recovery conditions are reviewed and an overall outline of immunologic aspects of COVID-19 progression and recovery in three different stages are presented. Finally, we categorized the infected cases into four different groups based on the acquired immunity and the potential for reinfection.\n\nIn this review paper, we proposed a new strategy to predict the potential of reinfection in each identified category. This classification may help to distribute resources more meticulously to determine: who needs to be serologically tested for SARS-CoV-2 neutralizing antibodies, what percentage of the population is immune to the virus, and who needs to be vaccinated.", "doi": "10.1016/j.jare.2020.12.013", "pmid": "33520309", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2090-1232(20)30263-0"}, {"db": "pmc", "key": "PMC7832464"}], "notes": [], "created": "2021-02-04T18:31:22.502Z", "modified": "2021-02-04T18:31:53.526Z"}, {"entity": "publication", "iuid": "3dd3f252fe0c478dab38a085893b9814", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3dd3f252fe0c478dab38a085893b9814.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3dd3f252fe0c478dab38a085893b9814"}}, "title": "COVID-19 and seafarers' rights to shore leave, repatriation and medical assistance: a pilot study.", "authors": [{"family": "Hebbar", "given": "Anish Arvind", "initials": "AA"}, {"family": "Mukesh", "given": "Nitin", "initials": "N"}], "type": "journal article", "published": "2021-01-05", "journal": {"title": "Int Marit Health", "issn": "2081-3252", "issn-l": null, "volume": "71", "issue": "4", "pages": "217-228"}, "abstract": "The well-being of the world's 1.65 million seafarers is expected to be secured by the rights established under the Maritime Labour Convention (MLC), 2006 with active monitoring of its implementation by the flag administrations through the International Maritime Organisation (IMO) and International Labour Organisation (ILO). However, the substantial gains achieved since entry into force of MLC in August 2013 appear to have been severely dented by the COVID-19 global pandemic. The aim of the study was to examine, on a pilot basis, the disruptions and challenges to the observance of seafarers' rights to shore leave, repatriation and medical assistance as an immediate consequence of COVID-19.\r\n\r\nThe impact of COVID-19 on seafarers' rights was examined in three dimensions - shore leave, repatriation and medical assistance. Questionnaires were administered online from June to August 2020 to 450 seafarers, top 10 ship-management companies, 35 shipping companies and maritime administrations of top 5 seafarer supplying countries. The paper discusses the results of the survey.\r\n\r\nThe research revealed a previously unknown majority preference for shore leave, that diminished sharply during COVID-19. Impact on work-performance and well-being of seafarers was revealed with only a fifth of the seafarers having willingly agreed to an extension of contract. This study revealed incidence rates at 6 months into the pandemic of several parameters - delayed repatriations (21.44%) that includes crew with contract extensions (12.48%), crew with completed contract awaiting repatriation (8.96%) and crew that had exceeded 12-month continuous service (0.82%). Compensation, if provided, is meagre and was affecting ratings the most. Deprivation of medical assistance was also revealed.\r\n\r\nThe well being of seafarers would likely remain vulnerable to breaches, unless measures are put in place to safeguard the rights assured under MLC in the face of uncertainties caused by a pandemic such as COVID-19.", "doi": "10.5603/IMH.2020.0040", "pmid": "33394486", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "VM/OJS/J/72010"}], "notes": [], "created": "2021-01-05T15:23:14.849Z", "modified": "2021-06-18T09:44:21.762Z"}, {"entity": "publication", "iuid": "01e5014ff5dc46a1a5e0b0b849134ab7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01e5014ff5dc46a1a5e0b0b849134ab7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01e5014ff5dc46a1a5e0b0b849134ab7"}}, "title": "The Swedish COVID-19 intensive care cohort: Risk of ICU admission and ICU mortality.", "authors": [{"family": "Ahlstr\u00f6m", "given": "B", "initials": "B"}, {"family": "Frithiof", "given": "R", "initials": "R"}, {"family": "Hultstr\u00f6m", "given": "M", "initials": "M"}, {"family": "Larsson", "given": "I-M", "initials": "I"}, {"family": "Strandberg", "given": "G", "initials": "G"}, {"family": "Lipcsey", "given": "M", "initials": "M"}], "type": "journal-article", "published": "2021-01-04", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "0001-5172", "issn-l": null, "volume": "65", "issue": "4", "pages": "525-533"}, "abstract": "Abstract\r\nBackground: Several studies have recently addressed factors associated with severe Coronavirus disease 2019 (COVID-19); however, some medications and comorbidities have yet to be evaluated in a large matched cohort. We therefore explored the role of relevant comorbidities and medications in relation to the risk of intensive care unit (ICU) admission and mortality.\r\n\r\nMethods: All ICU COVID-19 patients in Sweden until 27 May 2020 were matched to population controls on age and sex to assess the risk of ICU admission. Cases were identified, comorbidities and medications were retrieved from high-quality registries. Three conditional logistic regression models were used for risk of ICU admission and three Cox proportional hazards models for risk of ICU mortality, one with comorbidities, one with medications and finally with both models combined, respectively.\r\n\r\nResults: We included 1981 patients and 7924 controls. Hypertension, type 2 diabetes mellitus, chronic renal failure, asthma, obesity, being a solid organ transplant recipient and immunosuppressant medications were independent risk factors of ICU admission and oral anticoagulants were protective. Stroke, asthma, chronic obstructive pulmonary disease and treatment with renin-angiotensin-aldosterone inhibitors (RAASi) were independent risk factors of ICU mortality in the pre-specified primary analyses; treatment with statins was protective. However, after adjusting for the use of continuous renal replacement therapy, RAASi were no longer an independent risk factor.\r\n\r\nConclusion: In our cohort oral anticoagulants were protective of ICU admission and statins was protective of ICU death. Several comorbidities and ongoing RAASi treatment were independent risk factors of ICU admission and ICU mortality.\r\n\r\nThis article is protected by", "doi": "10.1111/aas.13781", "pmid": "33438198", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-04T09:13:48.635Z", "modified": "2022-02-14T15:44:21.282Z"}, {"entity": "publication", "iuid": "fd2d575684ab488480008cfc0b6bae18", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fd2d575684ab488480008cfc0b6bae18.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fd2d575684ab488480008cfc0b6bae18"}}, "title": "SARS-CoV-2 encephalitis is a cytokine release syndrome: evidences from cerebrospinal fluid analyses", "authors": [{"family": "Pilotto", "given": "Andrea", "initials": "A"}, {"family": "Masciocchi", "given": "Stefano", "initials": "S"}, {"family": "Volonghi", "given": "Irene", "initials": "I"}, {"family": "De Giuli", "given": "Valeria", "initials": "V"}, {"family": "Caprioli", "given": "Francesca", "initials": "F"}, {"family": "Mariotto", "given": "Sara", "initials": "S"}, {"family": "Ferrari", "given": "Sergio", "initials": "S"}, {"family": "Bozzetti", "given": "Silvia", "initials": "S"}, {"family": "Imarisio", "given": "Alberto", "initials": "A"}, {"family": "Risi", "given": "Barbara", "initials": "B"}, {"family": "Premi", "given": "Enrico", "initials": "E"}, {"family": "Benussi", "given": "Alberto", "initials": "A"}, {"family": "Foc\u00e0", "given": "Emanuele", "initials": "E"}, {"family": "Castelli", "given": "Francesco", "initials": "F"}, {"family": "Zanusso", "given": "Gianluigi", "initials": "G"}, {"family": "Monaco", "given": "Salvatore", "initials": "S"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Gasparotti", "given": "Roberto", "initials": "R"}, {"family": "Zekeridou", "given": "Anastasia", "initials": "A"}, {"family": "McKeon", "given": "Andrew", "initials": "A"}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ"}, {"family": "Blennov", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Padovani", "given": "Alessandro", "initials": "A"}], "type": "journal-article", "published": "2021-01-04", "journal": {"title": "Clin Infect Dis", "issn": "1058-4838", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1093/cid/ciaa1933", "pmid": null, "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available in paper: Clinical features, imaging and CSF biochemical analyses of SARS-CoV-2 encephalitis cases", "description": null}, {"db": "NA", "key": "Available in paper: Clinical features, imaging and CSF biochemical analyses of COV-Enc cases", "description": null}], "notes": [], "created": "2021-01-05T15:20:43.277Z", "modified": "2021-06-18T10:02:34.967Z"}, {"entity": "publication", "iuid": "07ae93d4452b4555a315d7225e13863b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/07ae93d4452b4555a315d7225e13863b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/07ae93d4452b4555a315d7225e13863b"}}, "title": "Public Mobility and Social Media Attention in Response to COVID-19 in Sweden and Denmark.", "authors": [{"family": "Zhang", "given": "Le", "initials": "L"}, {"family": "Brikell", "given": "Isabell", "initials": "I"}, {"family": "Dalsgaard", "given": "S\u00f8ren", "initials": "S"}, {"family": "Chang", "given": "Zheng", "initials": "Z"}], "type": "journal article", "published": "2021-01-04", "journal": {"title": "JAMA Netw Open", "issn": "2574-3805", "volume": "4", "issue": "1", "pages": "e2033478", "issn-l": null}, "abstract": null, "doi": "10.1001/jamanetworkopen.2020.33478", "pmid": "33394001", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "2774527"}], "notes": [], "created": "2021-01-07T10:04:55.103Z", "modified": "2021-02-26T08:46:59.814Z"}, {"entity": "publication", "iuid": "ddf4db5c2836473c816d391d7b547eb9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ddf4db5c2836473c816d391d7b547eb9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ddf4db5c2836473c816d391d7b547eb9"}}, "title": "More research is needed on the long-term effects of COVID-19 on children and adolescents.", "authors": [{"family": "Hertting", "given": "Olof", "initials": "O"}], "type": "editorial", "published": "2021-01-04", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": null, "issue": null, "pages": null}, "abstract": "Editorial", "doi": "10.1111/apa.15731", "pmid": "33395729", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-07T10:00:23.633Z", "modified": "2021-01-07T10:00:46.227Z"}, {"entity": "publication", "iuid": "52f8c81d169e44dfa9c5a9e9ee5622a8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/52f8c81d169e44dfa9c5a9e9ee5622a8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/52f8c81d169e44dfa9c5a9e9ee5622a8"}}, "title": "Little evidence for facemask use in children against COVID-19.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "editorial", "published": "2021-01-03", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": null, "issue": null, "pages": null}, "abstract": "Editorial", "doi": "10.1111/apa.15729", "pmid": "33393117", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-07T09:56:13.495Z", "modified": "2021-01-07T09:56:56.673Z"}, {"entity": "publication", "iuid": "6d40a9ed6d164a33a7968a3d377566db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6d40a9ed6d164a33a7968a3d377566db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6d40a9ed6d164a33a7968a3d377566db"}}, "title": "Treatment of severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19): a systematic review of in vitro, in vivo, and clinical trials.", "authors": [{"family": "Han", "given": "Young Joo", "initials": "YJ"}, {"family": "Lee", "given": "Keum Hwa", "initials": "KH"}, {"family": "Yoon", "given": "Sojung", "initials": "S"}, {"family": "Nam", "given": "Seoung Wan", "initials": "SW"}, {"family": "Ryu", "given": "Seohyun", "initials": "S"}, {"family": "Seong", "given": "Dawon", "initials": "D"}, {"family": "Kim", "given": "Jae Seok", "initials": "JS"}, {"family": "Lee", "given": "Jun Young", "initials": "JY"}, {"family": "Yang", "given": "Jae Won", "initials": "JW"}, {"family": "Lee", "given": "Jinhee", "initials": "J"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Hong", "given": "Sung Hwi", "initials": "SH"}, {"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Smith", "given": "Lee", "initials": "L"}, {"family": "Oh", "given": "Hans", "initials": "H"}, {"family": "Ghayda", "given": "Ramy Abou", "initials": "RA"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Effenberger", "given": "Maria", "initials": "M"}, {"family": "Kresse", "given": "Daniela", "initials": "D"}, {"family": "Denicol\u00f2", "given": "Sara", "initials": "S"}, {"family": "Kang", "given": "Woosun", "initials": "W"}, {"family": "Jacob", "given": "Louis", "initials": "L"}, {"family": "Shin", "given": "Hanwul", "initials": "H"}, {"family": "Shin", "given": "Jae Il", "initials": "JI"}], "type": "journal article", "published": "2021-01-01", "journal": {"title": "Theranostics", "issn": "1838-7640", "volume": "11", "issue": "3", "pages": "1207-1231", "issn-l": null}, "abstract": "Rationale: Coronavirus disease 2019 (COVID-19) has spread worldwide and poses a threat to humanity. However, no specific therapy has been established for this disease yet. We conducted a systematic review to highlight therapeutic agents that might be effective in treating COVID-19. Methods: We searched Medline, Medrxiv.org, and reference lists of relevant publications to identify articles of in vitro, in vivo, and clinical studies on treatments for severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and COVID-19 published in English until the last update on October 11, 2020. Results: We included 36 studies on SARS, 30 studies on MERS, and 10 meta-analyses on SARS and MERS in this study. Through 12,200 title and 830 full-text screenings for COVID-19, eight in vitro studies, 46 randomized controlled trials (RCTs) on 6,886 patients, and 29 meta-analyses were obtained and investigated. There was no therapeutic agent that consistently resulted in positive outcomes across SARS, MERS, and COVID-19. Remdesivir showed a therapeutic effect for COVID-19 in two RCTs involving the largest number of total participants (n = 1,461). Other therapies that showed an effect in at least two RCTs for COVID-19 were sofosbuvir/daclatasvir (n = 114), colchicine (n = 140), IFN-\u03b21b (n = 193), and convalescent plasma therapy (n = 126). Conclusions: This review provides information to help establish treatment and research directions for COVID-19 based on currently available evidence. Further RCTs are required.", "doi": "10.7150/thno.48342", "pmid": "33391531", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "thnov11p1207"}, {"db": "pmc", "key": "PMC7738873"}], "notes": [], "created": "2021-01-07T11:19:21.921Z", "modified": "2021-01-07T11:19:21.947Z"}, {"entity": "publication", "iuid": "53ae2386675c4a4ba33a03cf8ce33fb7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53ae2386675c4a4ba33a03cf8ce33fb7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53ae2386675c4a4ba33a03cf8ce33fb7"}}, "title": "The ABCs of Covid-19 prevention in Malawi: Authority, benefits, and costs of compliance.", "authors": [{"family": "Kao", "given": "Kristen", "initials": "K"}, {"family": "Lust", "given": "Ellen", "initials": "E"}, {"family": "Dulani", "given": "Boniface", "initials": "B"}, {"family": "Ferree", "given": "Karen E", "initials": "KE"}, {"family": "Harris", "given": "Adam S", "initials": "AS"}, {"family": "Metheney", "given": "Erica", "initials": "E"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "World Dev", "issn": "0305-750X", "volume": "137", "issue": null, "pages": "105167", "issn-l": null}, "abstract": "A wide array of authorities-from religious leaders to government ministers-call upon citizens to take preventative measures against Covid-19. Which authorities can most effectively gain public compliance, and which measures will the public take up? Moreover, do people comply with authorities out of respect for their legitimacy, due to their expertise, or for fear of sanctioning? Answers to these questions are important for development practitioners, who need to understand how different partnerships might affect health behavior, and for scholars interested in understanding authority, legitimacy, and compliance. We explore these questions using a conjoint experiment embedded in a telephone survey of 641 Malawians. Individuals in our sample are more likely to say that they will comply with precautionary measures when the costs are low and expected benefits are high. Respondents view both traditional authorities and hospital heads as legitimately issuing directives and having the ability to monitor and sanction non-compliance, but appear to comply more with hospital heads and to do so out of respect for their expertise. These results emphasize how who issues directives affects whether individuals comply and provides insights as to why they do so. The findings also reflect individuals' cost-benefit calculations when considering precautionary measures, highlighting the importance of steps that can reduce costs (e.g., food security or income measures) or accurately reflect risks (e.g., information signaling the prevalence of Covid-19). The study not only helps to address the Coronavirus crisis but also has important implications for broader questions of authority and compliance.", "doi": "10.1016/j.worlddev.2020.105167", "pmid": "32904501", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0305-750X(20)30294-1"}, {"db": "pii", "key": "105167"}, {"db": "pmc", "key": "PMC7455236"}], "notes": [], "created": "2020-12-03T16:14:55.886Z", "modified": "2020-12-03T16:14:55.900Z"}, {"entity": "publication", "iuid": "d12ec989605142b5bc38043f089487db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d12ec989605142b5bc38043f089487db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d12ec989605142b5bc38043f089487db"}}, "title": "Temporal increase in D614G mutation of SARS-CoV-2 in the Middle East and North Africa.", "authors": [{"family": "Sallam", "given": "Malik", "initials": "M"}, {"family": "Ababneh", "given": "Nidaa A", "initials": "NA"}, {"family": "Dababseh", "given": "Deema", "initials": "D"}, {"family": "Bakri", "given": "Faris G", "initials": "FG"}, {"family": "Mahafzah", "given": "Azmi", "initials": "A"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": "7", "issue": "1", "pages": "e06035", "issn-l": null}, "abstract": "Phylogeny construction can help to reveal evolutionary relatedness among molecular sequences. The spike ( S) gene of SARS-CoV-2 is the subject of an immune selective pressure which increases the variability in such region. This study aimed to identify mutations in the S gene among SARS-CoV-2 sequences collected in the Middle East and North Africa (MENA), focusing on the D614G mutation, that has a presumed fitness advantage. Another aim was to analyze the S gene sequences phylogenetically.\n\nThe SARS-CoV-2 S gene sequences collected in the MENA were retrieved from the GISAID public database, together with its metadata. Mutation analysis was conducted in Molecular Evolutionary Genetics Analysis software. Phylogenetic analysis was done using maximum likelihood (ML) and Bayesian methods.\n\nA total of 553 MENA sequences were analyzed and the most frequent S gene mutations included: D614G = 435, Q677H = 8, and V6F = 5. A significant increase in the proportion of D614G was noticed from (63.0%) in February 2020, to (98.5%) in June 2020 (p < 0.001). Two large phylogenetic clusters were identified via ML analysis, which showed an evidence of inter-country mixing of sequences, which dated back to February 8, 2020 and March 15, 2020 (median estimates). The mean evolutionary rate for SARS-CoV-2 was about 6.5 \u00d7 10-3 substitutions/site/year based on large clusters' Bayesian analyses.\n\nThe D614G mutation appeared to be taking over the COVID-19 infections in the MENA. Bayesian analysis suggested that SARS-CoV-2 might have been circulating in MENA earlier than previously reported.", "doi": "10.1016/j.heliyon.2021.e06035", "pmid": "33495741", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(21)00140-7"}, {"db": "pmc", "key": "PMC7817394"}], "notes": [], "created": "2021-01-29T15:21:33.803Z", "modified": "2021-02-26T08:45:14.457Z"}, {"entity": "publication", "iuid": "b45d9aadb46742d991a0e44c8f1c65b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b45d9aadb46742d991a0e44c8f1c65b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b45d9aadb46742d991a0e44c8f1c65b4"}}, "title": "Sex differences in COVID-19: the role of androgens in disease severity and progression.", "authors": [{"family": "Mohamed", "given": "Mohamed S", "initials": "MS"}, {"family": "Moulin", "given": "Thiago C", "initials": "TC", "orcid": "0000-0001-7811-5383", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5480e69e1fd4d3cb11c758c637ab663.json"}}, {"family": "Schi\u00f6th", "given": "Helgi B", "initials": "HB"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Endocrine", "issn": "1559-0100", "issn-l": "1355-008X", "volume": "71", "issue": "1", "pages": "3-8"}, "abstract": "Throughout the SARS-CoV2 pandemic, multiple reports show higher percentages of hospitalization, morbidity, and mortality among men than women, indicating that men are more affected by COVID-19. The pathophysiology of this difference is yet not established, but recent studies suggest that sex hormones may influence the viral infectivity process. Here, we review the current evidence of androgen sensitivity as a decisive factor for COVID-19 disease severity.\n\nRelevant literature investigating the role of androgens in COVID-19 was assessed. Further, we describe several drugs suggested as beneficial for COVID-19 treatment related to androgen pathways. Lastly, we looked at androgen sensitivity as a predictor for COVID-19 progression and ongoing clinical trials on androgen suppression therapies as a line of treatment.\n\nSARS-COV2 virus spike proteins utilize Transmembrane protease serine 2 (TMPRSS2) for host entry. Androgen receptors are transcription promoters for TMPRSS2 and can, therefore, facilitate SARS-COV2 entry. Variants in the androgen receptor gene correlate with androgen sensitivity and are implicated in diseases like androgenetic alopecia and prostate cancer, conditions that have been associated with worse COVID-19 outcomes and hospitalization.\n\nAndrogen's TMPRSS2-mediated actions might explain both the low fatalities observed in prepubertal children and the differences between sexes regarding SARS-COV2 infection. Androgen sensitivity may be a critical factor in determining COVID-19 disease severity, and sensitivity tests can, therefore, help in predicting patient outcomes.", "doi": "10.1007/s12020-020-02536-6", "pmid": "33179220", "labels": {"Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7657570"}, {"db": "pii", "key": "10.1007/s12020-020-02536-6"}], "notes": [], "created": "2020-11-17T18:06:21.476Z", "modified": "2023-01-13T13:22:07.725Z"}, {"entity": "publication", "iuid": "62b7afd26bb74034adc40ba88cb53b7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/62b7afd26bb74034adc40ba88cb53b7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/62b7afd26bb74034adc40ba88cb53b7e"}}, "title": "SARS-CoV-2, testosterone and frailty in males (PROTEGGIMI): A multidimensional research project.", "authors": [{"family": "Salonia", "given": "Andrea", "initials": "A", "orcid": "0000-0002-0595-7165", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/940b454070ba44e8ad349d3c8f6c06c3.json"}}, {"family": "Corona", "given": "Giovanni", "initials": "G", "orcid": "0000-0002-9894-2885", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a16ac7355400404b898586d50aabdb10.json"}}, {"family": "Giwercman", "given": "Aleksander", "initials": "A", "orcid": "0000-0001-5816-0785", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c0fd6b6404f946e7aab84d821930a751.json"}}, {"family": "Maggi", "given": "Mario", "initials": "M", "orcid": "0000-0003-3267-4221", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/088328c481194b519fe8c3b994b186f8.json"}}, {"family": "Minhas", "given": "Suks", "initials": "S", "orcid": "0000-0001-6516-619X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7f662b0ec134b2197ef8f15deb12468.json"}}, {"family": "Nappi", "given": "Rossella E", "initials": "RE", "orcid": "0000-0002-5216-9882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c88e19ec3901486e9a11f8bfb30a77be.json"}}, {"family": "Sofikitis", "given": "Nikolaos", "initials": "N", "orcid": "0000-0003-1528-4029", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/878fcbbf78bf4f98bc7622484e44415d.json"}}, {"family": "Vignozzi", "given": "Linda", "initials": "L", "orcid": "0000-0003-0907-0630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40adf501a0ac4e3ab32759026e837fce.json"}}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Andrology", "issn": "2047-2927", "volume": "9", "issue": "1", "pages": "19-22", "issn-l": null}, "abstract": "Preliminary published data depict a much greater prevalence of males with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) referred for intensive care unit admission and severe sequelae in several countries. In this context, males seem to not only be more susceptible to the infection compared to female subjects, at least in Western countries, but their case fatality rate attributable to SARS-CoV-2 infection is also highest. Therefore, we may speculate that the different hormonal milieu could have a more profound pathophysiological role in association with SARS-CoV-2, with endogenous testosterone leaving men more prone to develop more serious complications related to the SARS-CoV-2 infection. Another option is that SARS-CoV-2 infection per se causes an acute stage of male hypogonadism, the depletion of androgenic action triggering serious or an even fatal course of the disease. Therefore, we strongly advocate the development of a prospective multidimensional andrological translational research project in men, which we called the PROTEGGIMI study. In this Opinion Article, we will not only highlight novel research activity in this area but also invite other researchers and learned scientific societies to join us in our efforts to understand an important and very newly discovered gap in knowledge, which may have serious implications for the lives of millions of men.", "doi": "10.1111/andr.12811", "pmid": "32369678", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-10T07:29:32.686Z", "modified": "2021-12-06T13:08:06.084Z"}, {"entity": "publication", "iuid": "586f3b487ead4831bce4bcfd52919638", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/586f3b487ead4831bce4bcfd52919638.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/586f3b487ead4831bce4bcfd52919638"}}, "title": "Prothrombotic changes in patients with COVID-19 are associated with disease severity and mortality.", "authors": [{"family": "von Meijenfeldt", "given": "Fien A", "initials": "FA"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Adelmeijer", "given": "Jelle", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A"}, {"family": "Rudberg", "given": "Ann-Sofie", "initials": "AS"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Thalin", "given": "Charlotte", "initials": "C"}, {"family": "Lisman", "given": "Ton", "initials": "T", "orcid": "0000-0002-3503-7140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7431e810d13c443ca5dacbf5d368e60b.json"}}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Res Pract Thromb Haemost", "issn": "2475-0379", "issn-l": null, "volume": "5", "issue": "1", "pages": "132-141"}, "abstract": "Patients with severe coronavirus disease 2019 (COVID-19) are at significant risk of thrombotic complications. However, their prothrombotic state is incompletely understood. Therefore, we measured in vivo activation markers of hemostasis, plasma levels of hemostatic proteins, and functional assays of coagulation and fibrinolysis in plasma from patients with COVID-19 and determined their association with disease severity and 30-day mortality.\n\nWe included 102 patients with COVID-19 receiving various levels of respiratory support admitted to general wards, intermediate units, or intensive care units and collected plasma samples shortly after hospital admission.\n\nPatients with COVID-19 with higher respiratory support had increased in vivo activation of coagulation and fibrinolysis, as reflected by higher plasma levels of d-dimer, thrombin-antithrombin, and plasmin-antiplasmin complexes as compared to patients with no to minimal respiratory support and healthy controls. Moreover, the patients with COVID-19 with higher respiratory support exhibited substantial ex vivo thrombin generation and lower ex vivo fibrinolytic capacity, despite higher doses of anticoagulant therapy compared to less severely ill patients. Fibrinogen, factor VIII, and von Willebrand factor levels increased, and ADAMTS13 levels decreased with increasing respiratory support in patients with COVID-19. Low platelet count; low levels of prothrombin, antithrombin, and ADAMTS13; and high levels of von Willebrand factor were associated with short-term mortality.\n\nSevere COVID-19 is associated with prothrombotic changes with increased in vivo activation of coagulation and fibrinolysis, despite anticoagulant therapy.", "doi": "10.1002/rth2.12462", "pmid": "33537537", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "RTH212462"}, {"db": "pmc", "key": "PMC7845083"}], "notes": [], "created": "2021-01-05T09:54:08.916Z", "modified": "2021-12-12T18:06:52.709Z"}, {"entity": "publication", "iuid": "b80e3c19bd144eefa0375ac53985e99d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b80e3c19bd144eefa0375ac53985e99d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b80e3c19bd144eefa0375ac53985e99d"}}, "title": "Priority setting during the COVID-19 pandemic: going beyond vaccines", "authors": [{"family": "Williams", "given": "Iestyn", "initials": "I"}, {"family": "Essue", "given": "Beverley", "initials": "B"}, {"family": "Nouvet", "given": "Elysee", "initials": "E"}, {"family": "Sandman", "given": "Lars", "initials": "L"}, {"family": "Razavi", "given": "S Donya", "initials": "SD"}, {"family": "Noorulhuda", "given": "Mariam", "initials": "M"}, {"family": "Goold", "given": "Susan", "initials": "S"}, {"family": "Danis", "given": "Marion", "initials": "M"}, {"family": "Biemba", "given": "Godfrey", "initials": "G"}, {"family": "Abelson", "given": "Julia", "initials": "J"}, {"family": "Kapiriri", "given": "Lydia", "initials": "L"}], "type": "journal-article", "published": "2021-01-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "1", "pages": "e004686", "issn-l": "2059-7908"}, "abstract": null, "doi": "10.1136/bmjgh-2020-004686", "pmid": "33461979", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-20T14:54:55.855Z", "modified": "2021-01-22T09:17:09.826Z"}, {"entity": "publication", "iuid": "c464dbf3e26d474cb38b3d0e0ffed683", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c464dbf3e26d474cb38b3d0e0ffed683.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c464dbf3e26d474cb38b3d0e0ffed683"}}, "title": "Precision shielding for COVID-19: metrics of assessment and feasibility of deployment.", "authors": [{"family": "Ioannidis", "given": "John P A", "initials": "JPA"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "6", "issue": "1", "issn-l": "2059-7908"}, "abstract": "The ability to preferentially protect high-risk groups in COVID-19 is hotly debated. Here, the aim is to present simple metrics of such precision shielding of people at high risk of death after infection by SARS-CoV-2; demonstrate how they can estimated; and examine whether precision shielding was successfully achieved in the first COVID-19 wave. The shielding ratio, S, is defined as the ratio of prevalence of infection among people in a high-risk group versus among people in a low-risk group. The contrasted risk groups examined here are according to age (\u226570 vs <70 years), and institutionalised (nursing home) setting. For age-related precision shielding, data were used from large seroprevalence studies with separate prevalence data for elderly versus non-elderly and with at least 1000 assessed people\u226570 years old. For setting-related precision shielding, data were analysed from 10 countries where information was available on numbers of nursing home residents, proportion of nursing home residents among COVID-19 deaths and overall population infection fatality rate (IFR). Across 17 seroprevalence studies, the shielding ratio S for elderly versus non-elderly varied between 0.4 (substantial shielding) and 1.6 (substantial inverse protection, that is, low-risk people being protected more than high-risk people). Five studies in the USA all yielded S=0.4-0.8, consistent with some shielding being achieved, while two studies in China yielded S=1.5-1.6, consistent with inverse protection. Assuming 25% IFR among nursing home residents, S values for nursing home residents ranged from 0.07 to 3.1. The best shielding was seen in South Korea (S=0.07) and modest shielding was achieved in Israel, Slovenia, Germany and Denmark. No shielding was achieved in Hungary and Sweden. In Belgium (S=1.9), the UK (S=2.2) and Spain (S=3.1), nursing home residents were far more frequently infected than the rest of the population. In conclusion, the experience from the first wave of COVID-19 suggests that different locations and settings varied markedly in the extent to which they protected high-risk groups. Both effective precision shielding and detrimental inverse protection can happen in real-life circumstances. COVID-19 interventions should seek to achieve maximal precision shielding.", "doi": "10.1136/bmjgh-2020-004614", "pmid": "33514595", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-004614"}, {"db": "pmc", "key": "PMC7849322"}], "notes": [], "created": "2021-02-04T18:40:10.775Z", "modified": "2021-02-04T18:40:33.901Z"}, {"entity": "publication", "iuid": "3d2760fc6be84cb79efc1d8324e0cee3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3d2760fc6be84cb79efc1d8324e0cee3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3d2760fc6be84cb79efc1d8324e0cee3"}}, "title": "Impact of the COVID\u201019 pandemic on statistical design and analysis plans for multidomain intervention clinical trials: Experience from World\u2010Wide FINGERS", "authors": [{"family": "R\u00f6hr", "given": "Susanne", "initials": "S"}, {"family": "Arai", "given": "Hidenori", "initials": "H"}, {"family": "Mangialasche", "given": "Francesca", "initials": "F"}, {"family": "Matsumoto", "given": "Nanae", "initials": "N"}, {"family": "Peltonen", "given": "Markku", "initials": "M"}, {"family": "Raman", "given": "Rema", "initials": "R"}, {"family": "Riedel\u2010Heller", "given": "Steffi G", "initials": "SG"}, {"family": "Sakurai", "given": "Takashi", "initials": "T"}, {"family": "Snyder", "given": "Heather M", "initials": "HM"}, {"family": "Sugimoto", "given": "Taiki", "initials": "T"}, {"family": "Carrillo", "given": "Maria", "initials": "M"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Espeland", "given": "Mark A", "initials": "MA"}, {"family": null, "given": "", "initials": ""}], "type": "journal-article", "published": "2021-01-00", "journal": {"title": "Alzheimers Dement (N Y)", "issn": "2352-8737", "issn-l": null, "volume": "7", "issue": "1", "pages": "e12143"}, "abstract": "The coronavirus disease-19 (COVID-19) pandemic presents challenges to the conduct of randomized clinical trials of lifestyle interventions.\r\n\r\nWorld-Wide FINGERS is an international network of clinical trials to assess the impact of multidomain lifestyle intervention on cognitive decline in at-risk adults. Individual trials are tailoring successful approaches from the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) to local cultures and environments. The network convened a forum for researchers to discuss statistical design and analysis issues they faced during the pandemic. We report on experiences of three trials that, at various stages of conduct, altered designs and analysis plans to navigate these issues. We provide recommendations for future trials to consider as they develop and launch behavioral intervention trials.\r\n\r\nThe pandemic led researchers to change recruitment plans, interrupt timelines for assessments and intervention delivery, and move to remote intervention and assessment protocols. The necessity of these changes add emphasis to the importance, in study design and analysis, of intention to treat approaches, flexibility, within-site stratification, interim power projections, and sensitivity analyses.\r\n\r\nRobust approaches to study design and analysis are critical to negotiate issues related to the intervention. The world-wide network of similarly oriented clinical trials will allow us to evaluate the effectiveness of responses to the pandemic across cultures, local environments, and phases of the pandemic.", "doi": "10.1002/trc2.12143", "pmid": "33738333", "labels": {"Category: Public Health": null, "Category: Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "TRC212143"}, {"db": "pmc", "key": "PMC7948446"}], "notes": [], "created": "2021-03-22T10:32:35.047Z", "modified": "2021-11-18T12:57:15.265Z"}, {"entity": "publication", "iuid": "3dfd0924e5504124abeb6987b92920b5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3dfd0924e5504124abeb6987b92920b5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3dfd0924e5504124abeb6987b92920b5"}}, "title": "Immune determinants of COVID-19 disease presentation and severity.", "authors": [{"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956", "volume": "27", "issue": "1", "pages": "28-33"}, "abstract": "COVID-19, caused by SARS-CoV-2 infection, is mild to moderate in the majority of previously healthy individuals, but can cause life-threatening disease or persistent debilitating symptoms in some cases. The most important determinant of disease severity is age, with individuals over 65 years having the greatest risk of requiring intensive care, and men are more susceptible than women. In contrast to other respiratory viral infections, young children seem to be less severely affected. It is now clear that mild to severe acute infection is not the only outcome of COVID-19, and long-lasting symptoms are also possible. In contrast to severe acute COVID-19, such 'long COVID' is seemingly more likely in women than in men. Also, postinfectious hyperinflammatory disease has been described as an additional outcome after SARS-CoV-2 infection. Here I discuss our current understanding of the immunological determinants of COVID-19 disease presentation and severity and relate this to known immune-system differences between young and old people and between men and women, and other factors associated with different disease presentations and severity.", "doi": "10.1038/s41591-020-01202-8", "pmid": "33442016", "labels": {"Category: Health": null, "Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-020-01202-8"}], "notes": [], "created": "2021-01-15T11:23:24.748Z", "modified": "2023-07-13T11:26:40.799Z"}, {"entity": "publication", "iuid": "f035e7ee455c4eb08c507a8789e62c5c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f035e7ee455c4eb08c507a8789e62c5c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f035e7ee455c4eb08c507a8789e62c5c"}}, "title": "How two concurrent pandemics put a spoke in the wheel of intensive pig production.", "authors": [{"family": "Millet", "given": "Sam", "initials": "S"}, {"family": "De Smet", "given": "Sarah", "initials": "S"}, {"family": "Knol", "given": "Egbert F", "initials": "EF"}, {"family": "Bee", "given": "Giuseppe", "initials": "G"}, {"family": "Trevisi", "given": "Paolo", "initials": "P"}, {"family": "Vigors", "given": "Stafford", "initials": "S"}, {"family": "Nilsson", "given": "Katja", "initials": "K"}, {"family": "Van Meensel", "given": "Jef", "initials": "J"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Anim Front", "issn": "2160-6064", "volume": "11", "issue": "1", "pages": "14-18", "issn-l": null}, "abstract": null, "doi": "10.1093/af/vfaa051", "pmid": "33575094", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "vfaa051"}, {"db": "pmc", "key": "PMC7863338"}], "notes": [], "created": "2021-02-15T12:54:51.195Z", "modified": "2021-02-15T12:54:51.217Z"}, {"entity": "publication", "iuid": "8c437356108544589e9b347f78ebee8b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c437356108544589e9b347f78ebee8b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c437356108544589e9b347f78ebee8b"}}, "title": "High levels of anxiety during the COVID-19 pandemic as a risk factor of clinical worsening in patients with severe asthma", "authors": [{"family": "Lacwik", "given": "Piotr", "initials": "P"}, {"family": "Szyd\u0142owska", "given": "Dorota", "initials": "D"}, {"family": "Kupczyk", "given": "Maciej", "initials": "M"}, {"family": "Pa\u0142czy\u0144ski", "given": "Cezary", "initials": "C"}, {"family": "Kuna", "given": "Piotr", "initials": "P"}], "type": "journal-article", "published": "2021-01-00", "journal": {"title": "The Journal of Allergy and Clinical Immunology: In Practice", "issn": "2213-2198", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.jaip.2020.12.060", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-15T13:17:12.974Z", "modified": "2021-02-26T08:45:48.448Z"}, {"entity": "publication", "iuid": "47b30bbdaf1c4ae592b17ab88b7f8376", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47b30bbdaf1c4ae592b17ab88b7f8376.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47b30bbdaf1c4ae592b17ab88b7f8376"}}, "title": "Detecting COVID-19 infection hotspots in England using large-scale self-reported data from a mobile application: a prospective, observational study.", "authors": [{"family": "Varsavsky", "given": "Thomas", "initials": "T"}, {"family": "Graham", "given": "Mark S", "initials": "MS"}, {"family": "Canas", "given": "Liane S", "initials": "LS"}, {"family": "Ganesh", "given": "Sajaysurya", "initials": "S"}, {"family": "Capdevila Pujol", "given": "Joan", "initials": "J"}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Murray", "given": "Benjamin", "initials": "B"}, {"family": "Modat", "given": "Marc", "initials": "M"}, {"family": "Jorge Cardoso", "given": "M", "initials": "M"}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Nguyen", "given": "Long H", "initials": "LH"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Gomez", "given": "Maria F", "initials": "MF"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "Davies", "given": "Richard", "initials": "R"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Spector", "given": "Tim D", "initials": "TD"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Lancet Public Health", "issn": "2468-2667", "issn-l": null, "volume": "6", "issue": "1", "pages": "e21-e29"}, "abstract": "As many countries seek to slow the spread of COVID-19 without reimposing national restrictions, it has become important to track the disease at a local level to identify areas in need of targeted intervention.\n\nIn this prospective, observational study, we did modelling using longitudinal, self-reported data from users of the COVID Symptom Study app in England between March 24, and Sept 29, 2020. Beginning on April 28, in England, the Department of Health and Social Care allocated RT-PCR tests for COVID-19 to app users who logged themselves as healthy at least once in 9 days and then reported any symptom. We calculated incidence of COVID-19 using the invited swab (RT-PCR) tests reported in the app, and we estimated prevalence using a symptom-based method (using logistic regression) and a method based on both symptoms and swab test results. We used incidence rates to estimate the effective reproduction number, R(t), modelling the system as a Poisson process and using Markov Chain Monte-Carlo. We used three datasets to validate our models: the Office for National Statistics (ONS) Community Infection Survey, the Real-time Assessment of Community Transmission (REACT-1) study, and UK Government testing data. We used geographically granular estimates to highlight regions with rapidly increasing case numbers, or hotspots.\n\nFrom March 24 to Sept 29, 2020, a total of 2 873 726 users living in England signed up to use the app, of whom 2 842 732 (98\u00b79%) provided valid age information and daily assessments. These users provided a total of 120 192 306 daily reports of their symptoms, and recorded the results of 169 682 invited swab tests. On a national level, our estimates of incidence and prevalence showed a similar sensitivity to changes to those reported in the ONS and REACT-1 studies. On Sept 28, 2020, we estimated an incidence of 15 841 (95% CI 14 023-17 885) daily cases, a prevalence of 0\u00b753% (0\u00b745-0\u00b760), and R(t) of 1\u00b717 (1\u00b715-1\u00b719) in England. On a geographically granular level, on Sept 28, 2020, we detected 15 (75%) of the 20 regions with highest incidence according to government test data.\n\nOur method could help to detect rapid case increases in regions where government testing provision is lower. Self-reported data from mobile applications can provide an agile resource to inform policy makers during a quickly moving pandemic, serving as a complementary resource to more traditional instruments for disease surveillance.\n\nZoe Global, UK Government Department of Health and Social Care, Wellcome Trust, UK Engineering and Physical Sciences Research Council, UK National Institute for Health Research, UK Medical Research Council and British Heart Foundation, Alzheimer's Society, Chronic Disease Research Foundation.", "doi": "10.1016/S2468-2667(20)30269-3", "pmid": "33278917", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7785969"}, {"db": "pii", "key": "S2468-2667(20)30269-3"}], "notes": [], "created": "2020-12-10T09:19:53.222Z", "modified": "2023-06-19T15:27:26.581Z"}, {"entity": "publication", "iuid": "578b0f69f60c4bfe8fe9b74ae778aa67", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/578b0f69f60c4bfe8fe9b74ae778aa67.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/578b0f69f60c4bfe8fe9b74ae778aa67"}}, "title": "Dementia research in 2020: moving forward despite the COVID-19 pandemic", "authors": [{"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Mangialasche", "given": "Francesca", "initials": "F"}], "type": "journal-article", "published": "2021-01-00", "journal": {"title": "The Lancet Neurology", "issn": "1474-4422", "issn-l": null, "volume": "20", "issue": "1", "pages": "3-5"}, "abstract": null, "doi": "10.1016/s1474-4422(20)30453-1", "pmid": "33340483", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1474-4422(20)30453-1"}], "notes": [], "created": "2021-01-10T18:08:57.324Z", "modified": "2021-07-14T07:50:57.871Z"}, {"entity": "publication", "iuid": "d98fd68a9852405a9a40f2927f65eaf4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d98fd68a9852405a9a40f2927f65eaf4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d98fd68a9852405a9a40f2927f65eaf4"}}, "title": "Cancer and Risk of COVID-19 Through a General Community Survey.", "authors": [{"family": "Lee", "given": "Karla A", "initials": "KA", "orcid": "0000-0001-5904-5586", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/acab9243ce90490f93e8fc4bb3e7f25f.json"}}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Sikavi", "given": "Daniel R", "initials": "DR"}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Nguyen", "given": "Long H", "initials": "LH"}, {"family": "Bowyer", "given": "Ruth C E", "initials": "RCE"}, {"family": "Cardoso", "given": "M Jorge", "initials": "MJ"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Freidin", "given": "Maxim B", "initials": "MB"}, {"family": "Gomez", "given": "Maria", "initials": "M"}, {"family": "Graham", "given": "Mark", "initials": "M"}, {"family": "Guo", "given": "Chuan-Guo", "initials": "CG"}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Kwon", "given": "Sohee", "initials": "S"}, {"family": "Lo", "given": "Chun-Han", "initials": "CH"}, {"family": "Lochlainn", "given": "Mary Ni", "initials": "MN"}, {"family": "Menni", "given": "Cristina", "initials": "C"}, {"family": "Murray", "given": "Benjamin", "initials": "B"}, {"family": "Mehta", "given": "Raaj", "initials": "R"}, {"family": "Song", "given": "Mingyang", "initials": "M"}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Bataille", "given": "Veronique", "initials": "V"}, {"family": "Varsavsky", "given": "Thomas", "initials": "T"}, {"family": "Visconti", "given": "Alessia", "initials": "A"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Spector", "given": "Tim D", "initials": "TD"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "COPE consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Oncologist", "issn": "1549-490X", "volume": "26", "issue": "1", "pages": "e182-e185", "issn-l": null}, "abstract": "Individuals with cancer may be at high risk for coronavirus disease 2019 (COVID-19) and adverse outcomes. However, evidence from large population-based studies examining whether cancer and cancer-related therapy exacerbates the risk of COVID-19 infection is still limited. Data were collected from the COVID Symptom Study smartphone application since March 29 through May 8, 2020. Among 23,266 participants with cancer and 1,784,293 without cancer, we documented 10,404 reports of a positive COVID-19 test. Compared with participants without cancer, those living with cancer had a 60% increased risk of a positive COVID-19 test. Among patients with cancer, current treatment with chemotherapy or immunotherapy was associated with a 2.2-fold increased risk of a positive test. The association between cancer and COVID-19 infection was stronger among participants >65 years and males. Future studies are needed to identify subgroups by tumor types and treatment regimens who are particularly at risk for COVID-19 infection and adverse outcomes.", "doi": "10.1634/theoncologist.2020-0572", "pmid": "32845538", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7460944"}], "notes": [], "created": "2020-12-07T10:25:23.865Z", "modified": "2023-06-19T15:27:14.731Z"}, {"entity": "publication", "iuid": "21351024191b4d2489d3ed081cb1a9a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/21351024191b4d2489d3ed081cb1a9a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/21351024191b4d2489d3ed081cb1a9a6"}}, "title": "Calling for pan-European commitment for rapid and sustained reduction in SARS-CoV-2 infections", "authors": [{"family": "Priesemann", "given": "Viola", "initials": "V"}, {"family": "Brinkmann", "given": "Melanie M", "initials": "MM"}, {"family": "Ciesek", "given": "Sandra", "initials": "S"}, {"family": "Cuschieri", "given": "Sarah", "initials": "S"}, {"family": "Czypionka", "given": "Thomas", "initials": "T"}, {"family": "Giordano", "given": "Giulia", "initials": "G"}, {"family": "Gurdasani", "given": "Deepti", "initials": "D"}, {"family": "Hanson", "given": "Claudia", "initials": "C"}, {"family": "Hens", "given": "Niel", "initials": "N"}, {"family": "Iftekhar", "given": "Emil", "initials": "E"}, {"family": "Kelly-Irving", "given": "Michelle", "initials": "M"}, {"family": "Klimek", "given": "Peter", "initials": "P"}, {"family": "Kretzschmar", "given": "Mirjam", "initials": "M"}, {"family": "Peichl", "given": "Andreas", "initials": "A"}, {"family": "Perc", "given": "Matja\u017e", "initials": "M"}, {"family": "Sannino", "given": "Francesco", "initials": "F"}, {"family": "Schernhammer", "given": "Eva", "initials": "E"}, {"family": "Schmidt", "given": "Alexander", "initials": "A"}, {"family": "Staines", "given": "Anthony", "initials": "A"}, {"family": "Szczurek", "given": "Ewa", "initials": "E"}], "type": "journal-article", "published": "2021-01-00", "journal": {"title": "Lancet", "issn": "0140-6736", "volume": "397", "issue": "10269", "pages": "92-93", "issn-l": null}, "abstract": null, "doi": "10.1016/s0140-6736(20)32625-8", "pmid": null, "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-10T17:37:45.890Z", "modified": "2021-07-14T07:47:49.897Z"}, {"entity": "publication", "iuid": "e21f5e5fd27d47eaab5a97c944fe7a4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e21f5e5fd27d47eaab5a97c944fe7a4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e21f5e5fd27d47eaab5a97c944fe7a4c"}}, "title": "Behaviour adoption approaches during public health emergencies: implications for the COVID-19 pandemic and beyond.", "authors": [{"family": "Jalloh", "given": "Mohamed F", "initials": "MF"}, {"family": "Nur", "given": "Aasli A", "initials": "AA"}, {"family": "Nur", "given": "Sophia A", "initials": "SA"}, {"family": "Winters", "given": "Maike", "initials": "M"}, {"family": "Bedson", "given": "Jamie", "initials": "J"}, {"family": "Pedi", "given": "Danielle", "initials": "D"}, {"family": "Prybylski", "given": "Dimitri", "initials": "D"}, {"family": "Namageyo-Funa", "given": "Apophia", "initials": "A"}, {"family": "Hageman", "given": "Kathy M", "initials": "KM"}, {"family": "Baker", "given": "Brian J", "initials": "BJ"}, {"family": "Jalloh", "given": "Mohammad B", "initials": "MB"}, {"family": "Eng", "given": "Eugenia", "initials": "E"}, {"family": "Nordenstedt", "given": "Helena", "initials": "H"}, {"family": "Hakim", "given": "Avi J", "initials": "AJ"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "issn-l": "2059-7908", "volume": "6", "issue": "1", "pages": null}, "abstract": "Human behaviour will continue to play an important role as the world grapples with public health threats. In this paper, we draw from the emerging evidence on behaviour adoption during diverse public health emergencies to develop a framework that contextualises behaviour adoption vis-\u00e0-vis a combination of top-down, intermediary and bottom-up approaches. Using the COVID-19 pandemic as a case study, we operationalise the contextual framework to demonstrate how these three approaches differ in terms of their implementation, underlying drivers of action, enforcement, reach and uptake. We illustrate how blended strategies that include all three approaches can help accelerate and sustain protective behaviours that will remain important even when safe and effective vaccines become more widely available. As the world grapples with the COVID-19 pandemic and prepares to respond to (re)emerging public health threats, our contextual framework can inform the design, implementation, tracking and evaluation of comprehensive public health and social measures during health emergencies.", "doi": "10.1136/bmjgh-2020-004450", "pmid": "33514594", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-004450"}, {"db": "pmc", "key": "PMC7849902"}], "notes": [], "created": "2021-02-04T18:43:49.858Z", "modified": "2021-06-18T08:42:50.268Z"}, {"entity": "publication", "iuid": "50d77049587b4cbca713719097ea35b1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50d77049587b4cbca713719097ea35b1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50d77049587b4cbca713719097ea35b1"}}, "title": "Adjuvanted SARS-CoV-2 spike protein elicits neutralizing antibodies and CD4 T cell responses after a single immunization in mice.", "authors": [{"family": "W\u00f8rzner", "given": "Katharina", "initials": "K"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Schmidt", "given": "Signe Tandrup", "initials": "ST"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Zimmermann", "given": "Julie", "initials": "J"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Christensen", "given": "Dennis", "initials": "D"}, {"family": "Pedersen", "given": "Gabriel Kristian", "initials": "GK"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "EBioMedicine", "issn": "2352-3964", "issn-l": null, "volume": "63", "issue": null, "pages": "103197"}, "abstract": "SARS-CoV-2 has caused a global pandemic, infecting millions of people. A safe, effective vaccine is urgently needed and remains a global health priority. Subunit vaccines are used successfully against other viruses when administered in the presence of an effective adjuvant.\n\nWe evaluated three different clinically tested adjuvant systems in combination with the SARS-CoV-2 pre-fusion stabilized (S-2P) spike protein using a one-dose regimen in mice.\n\nWhilst spike protein alone was only weakly immunogenic, the addition of either Aluminum hydroxide, a squalene based oil-in-water emulsion system (SE) or a cationic liposome-based adjuvant significantly enhanced antibody responses against the spike receptor binding domain (RBD). Kinetics of antibody responses differed, with SE providing the most rapid response. Neutralizing antibodies developed after a single immunization in all adjuvanted groups with ID50 titers ranging from 86-4063. Spike-specific CD4 T helper responses were also elicited, comprising mainly of IFN-\u03b3 and IL-17 producing cells in the cationic liposome adjuvanted group, and more IL-5- and IL-10-secreting cells in the AH group.\n\nThese results demonstrate that adjuvanted spike protein subunit vaccine is a viable strategy for rapidly eliciting SARS-CoV-2 neutralizing antibodies and CD4 T cell responses of various qualities depending on the adjuvant used, which can be explored in further vaccine development against COVID-19.\n\nThis work was supported by the European Union Horizon 2020 research and innovation program under grant agreement no. 101003653.", "doi": "10.1016/j.ebiom.2020.103197", "pmid": "33422991", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Funder: H2020": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S2352-3964(20)30573-9"}, {"db": "pmc", "key": "PMC7808923"}], "notes": [], "created": "2021-02-01T14:20:38.962Z", "modified": "2021-09-27T12:30:15.492Z"}, {"entity": "publication", "iuid": "74f80925f92944c2b0a459fc6ba357b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/74f80925f92944c2b0a459fc6ba357b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/74f80925f92944c2b0a459fc6ba357b9"}}, "title": "Optimization Models for Medical Procedures Relocation", "authors": [{"family": "Nguyen", "given": "Linh Anh", "initials": "LA"}, {"family": "Sza\u0142as", "given": "Andrzej", "initials": "A"}], "type": "journal-article", "published": "2021-00-00", "journal": {"title": "Procedia Computer Science", "issn": "1877-0509", "volume": "192", "pages": "2058-2067", "issn-l": null}, "abstract": null, "doi": "10.1016/j.procs.2021.08.212", "pmid": null, "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2021-10-11T17:49:32.798Z", "modified": "2021-10-11T17:49:32.836Z"}, {"entity": "publication", "iuid": "fec3de621d134d748f62bd75b53bca7f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fec3de621d134d748f62bd75b53bca7f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fec3de621d134d748f62bd75b53bca7f"}}, "title": "High but slightly declining COVID-19 vaccine acceptance and reasons for vaccine acceptance, Finland April to December 2020\u2013Corrigendum", "authors": [{"family": "Hammer", "given": "Harlotte C", "initials": "HC"}, {"family": "Cristea", "given": "Veronica", "initials": "V"}, {"family": "Dub", "given": "Timothee", "initials": "T"}, {"family": "Sivel\u00e4", "given": "Jonas", "initials": "J"}], "type": "journal-article", "published": "2021-00-00", "journal": {"title": "Epidemiol. Infect.", "issn": "0950-2688", "issn-l": null, "volume": "149", "issue": null, "pages": null}, "abstract": null, "doi": "10.1017/s0950268821001217", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-07T05:39:16.056Z", "modified": "2021-06-18T08:31:17.891Z"}, {"entity": "publication", "iuid": "bdb24c0ca1e6408aa905b6e61a296572", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bdb24c0ca1e6408aa905b6e61a296572.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bdb24c0ca1e6408aa905b6e61a296572"}}, "title": "Cardiovascular biomarkers in patients with COVID-19", "authors": [], "type": "journal-article", "published": "2021-00-00", "journal": {"title": "European Heart Journal. Acute Cardiovascular Care", "issn": "2048-8726", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has increased awareness that severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2) may have profound effects on the cardiovascular system. COVID-19 often affects patients with pre-existing cardiac disease, and may trigger acute respiratory distress syndrome (ARDS), venous thromboembolism (VTE), acute myocardial infarction (AMI), and acute heart failure (AHF). However, as COVID-19 is primarily a respiratory infectious disease, there remain substantial uncertainty and controversy whether and how cardiovascular biomarkers should be used in patients with suspected COVID-19. To help clinicians understand the possible value as well as the most appropriate interpretation of cardiovascular biomarkers in COVID-19, it is important to highlight that recent findings regarding the prognostic role of cardiovascular biomarkers in patients hospitalized with COVID-19 are similar to those obtained in studies for pneumonia and ARDS in general. Cardiovascular biomarkers reflecting pathophysiological processes involved in COVID-19/pneumonia and its complications have a role evaluating disease severity, cardiac involvement, and risk of death in COVID-19 as well as in pneumonias caused by other pathogens. First, cardiomyocyte injury, as quantified by cardiac troponin concentrations, and haemodynamic cardiac stress, as quantified by natriuretic peptide concentrations, may occur in COVID-19 as in other pneumonias. The level of those biomarkers correlates with disease severity and mortality. Interpretation of cardiac troponin and natriuretic peptide concentrations as quantitative variables may aid in risk stratification in COVID-19/pneumonia and also will ensure that these biomarkers maintain high diagnostic accuracy for AMI and AHF. Second, activated coagulation as quantified by D-dimers seems more prominent in COVID-19 as in other pneumonias. Due to the central role of endothelitis and VTE in COVID-19, serial measurements of D-dimers may help physicians in the selection of patients for VTE imaging and the intensification of the level of anticoagulation from prophylactic to slightly higher or even therapeutic doses.", "doi": "https://doi.org/10.1093/ehjacc/zuab009", "pmid": "33655301", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-03-03T17:05:20.326Z", "modified": "2021-04-29T16:36:41.229Z"}, {"entity": "publication", "iuid": "bcc82c78df254978bd0fe5cdaa6720fe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bcc82c78df254978bd0fe5cdaa6720fe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bcc82c78df254978bd0fe5cdaa6720fe"}}, "title": "Genetic predisposition to allergic diseases is inversely associated with risk of COVID-19.", "authors": [{"family": "Larsson", "given": "Susanna C", "initials": "SC"}, {"family": "Gill", "given": "Dipender", "initials": "D"}], "type": "letter", "published": "2020-12-31", "journal": {"title": "Allergy", "issn": "1398-9995", "issn-l": "0105-4538", "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1111/all.14728", "pmid": "33382452", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-07T12:06:29.481Z", "modified": "2021-02-26T08:45:48.625Z"}, {"entity": "publication", "iuid": "6587831184184af6a1f19ec09c12c099", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6587831184184af6a1f19ec09c12c099.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6587831184184af6a1f19ec09c12c099"}}, "title": "Eco-epidemiological assessment of the COVID-19 epidemic in China, January-February 2020.", "authors": [{"family": "Byass", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2020-12-31", "journal": {"title": "Glob Health Action", "issn": "1654-9880", "issn-l": null, "volume": "13", "issue": "1", "pages": "1760490"}, "abstract": "Background: The outbreak of COVID-19 in China in early 2020 provides a rich data source for exploring the ecological determinants of this new infection, which may be of relevance as the pandemic develops.Objectives: Assessing the spread of the COVID-19 across China, in relation to associations between cases and ecological factors including population density, temperature, solar radiation and precipitation.Methods: Open-access COVID-19 case data include 18,069 geo-located cases in China during January and February 2020, which were mapped onto a 0.25\u00b0 latitude/longitude grid together with population and weather data (temperature, solar radiation and precipitation). Of 15,539 grid cells, 559 (3.6%) contained at least one case, and these were used to construct a Poisson regression model of cell-weeks. Weather parameters were taken for the preceding week given the established 5-7 day incubation period for COVID-19. The dependent variable in the Poisson model was incident cases per cell-week and exposure was cell population, allowing for clustering of cells over weeks, to give incidence rate ratios.Results: The overall COVID-19 incidence rate in cells with confirmed cases was 0.12 per 1,000. There was a single confirmed case in 113/559 (20.2%) of cells, while two grid cells recorded over 1,000 confirmed cases. Weekly means of maximum daily temperature varied from -28.0\u00b0C to 30.1\u00b0C, minimum daily temperature from -42.4\u00b0C to 23.0\u00b0C, maximum solar radiation from 0.04 to 2.74 MJm-2 and total precipitation from 0 to 72.6 mm. Adjusted incidence rate ratios suggested brighter, warmer and drier conditions were associated with lower incidence.Conclusion: Though not demonstrating cause and effect, there were appreciable associations between weather and COVID-19 incidence during the epidemic in China. This does not mean the pandemic will go away with summer weather but demonstrates the importance of using weather conditions in understanding and forecasting the spread of COVID-19.", "doi": "10.1080/16549716.2020.1760490", "pmid": "32404043", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7269037"}], "notes": [], "created": "2020-12-10T08:44:08.879Z", "modified": "2021-02-26T08:46:59.993Z"}, {"entity": "publication", "iuid": "7a40667eeaac4d1cb2751b5cb03d7639", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a40667eeaac4d1cb2751b5cb03d7639.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a40667eeaac4d1cb2751b5cb03d7639"}}, "title": "A direct RT-qPCR approach to test large numbers of individuals for SARS-CoV-2.", "authors": [{"family": "Maricic", "given": "Tomislav", "initials": "T"}, {"family": "Nickel", "given": "Olaf", "initials": "O"}, {"family": "Aximu-Petri", "given": "Ayinuer", "initials": "A"}, {"family": "Essel", "given": "Elena", "initials": "E"}, {"family": "Gansauge", "given": "Marie", "initials": "M"}, {"family": "Kanis", "given": "Philipp", "initials": "P"}, {"family": "Macak", "given": "Dominik", "initials": "D"}, {"family": "Richter", "given": "Julia", "initials": "J"}, {"family": "Riesenberg", "given": "Stephan", "initials": "S"}, {"family": "Bokelmann", "given": "Lukas", "initials": "L"}, {"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "Meyer", "given": "Matthias", "initials": "M"}, {"family": "Borte", "given": "Stephan", "initials": "S"}, {"family": "P\u00e4\u00e4bo", "given": "Svante", "initials": "S"}], "type": "journal article", "published": "2020-12-31", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "15", "issue": "12", "pages": "e0244824", "issn-l": "1932-6203"}, "abstract": "SARS-CoV-2 causes substantial morbidity and mortality in elderly and immunocompromised individuals, particularly in retirement homes, where transmission from asymptomatic staff and visitors may introduce the infection. Here we present a cheap and fast screening method based on direct RT-qPCR to detect SARS-CoV-2 in single or pooled gargle lavages (\"mouthwashes\"). This method detects individuals with large viral loads (Ct\u226429) and we use it to test all staff at a nursing home daily over a period of three weeks in order to reduce the risk that the infection penetrates the facility. This or similar approaches can be implemented to protect hospitals, nursing homes and other institutions in this and future viral epidemics.", "doi": "10.1371/journal.pone.0244824", "pmid": "33382830", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0244824#sec013", "description": "All data are available in the supplementary information"}], "notes": [], "created": "2021-01-07T11:53:04.600Z", "modified": "2021-11-18T12:42:52.436Z"}, {"entity": "publication", "iuid": "f15874bd4c424661b8db73c43a1afd31", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f15874bd4c424661b8db73c43a1afd31.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f15874bd4c424661b8db73c43a1afd31"}}, "title": "Time Trends of the Public\u2019s Attention Toward Suicide During the COVID-19 Pandemic: Retrospective, Longitudinal Time-Series Study", "authors": [{"family": "Burnett", "given": "Dayle", "initials": "D"}, {"family": "Eapen", "given": "Valsamma", "initials": "V"}, {"family": "Lin", "given": "Ping I", "initials": "PI"}], "type": "journal-article", "published": "2020-12-30", "journal": {"title": "JMIR Public Health Surveill", "issn": "2369-2960", "volume": "6", "issue": "4", "pages": "e24694", "issn-l": null}, "abstract": null, "doi": "10.2196/24694", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-10T18:13:57.524Z", "modified": "2021-02-26T08:47:00.305Z"}, {"entity": "publication", "iuid": "95a37cbd41734367bc2b23e615569b9f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95a37cbd41734367bc2b23e615569b9f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95a37cbd41734367bc2b23e615569b9f"}}, "title": "Integrating the social sciences in epidemic preparedness and response: A strategic framework to strengthen capacities and improve Global Health security.", "authors": [{"family": "Bardosh", "given": "Kevin Louis", "initials": "KL"}, {"family": "de Vries", "given": "Daniel H", "initials": "DH"}, {"family": "Abramowitz", "given": "Sharon", "initials": "S"}, {"family": "Thorlie", "given": "Adama", "initials": "A"}, {"family": "Cremers", "given": "Lianne", "initials": "L"}, {"family": "Kinsman", "given": "John", "initials": "J"}, {"family": "Stellmach", "given": "Darryl", "initials": "D"}], "type": "journal article", "published": "2020-12-30", "journal": {"title": "Global Health", "issn": "1744-8603", "volume": "16", "issue": "1", "pages": "120", "issn-l": "1744-8603"}, "abstract": "The importance of integrating the social sciences in epidemic preparedness and response has become a common feature of infectious disease policy and practice debates. However to date, this integration remains inadequate, fragmented and under-funded, with limited reach and small initial investments. Based on data collected prior to the COVID-19 pandemic, in this paper we analysed the variety of knowledge, infrastructure and funding gaps that hinder the full integration of the social sciences in epidemics and present a strategic framework for addressing them.\n\nSenior social scientists with expertise in public health emergencies facilitated expert deliberations, and conducted 75 key informant interviews, a consultation with 20 expert social scientists from Africa, Asia and Europe, 2 focus groups and a literature review of 128 identified high-priority peer reviewed articles. We also analysed 56 interviews from the Ebola 100 project, collected just after the West African Ebola epidemic. Analysis was conducted on gaps and recommendations. These were inductively classified according to various themes during two group prioritization exercises. The project was conducted between February and May 2019. Findings from the report were used to inform strategic prioritization of global investments in social science capacities for health emergencies.\n\nOur analysis consolidated 12 knowledge and infrastructure gaps and 38 recommendations from an initial list of 600 gaps and 220 recommendations. In developing our framework, we clustered these into three areas: 1) Recommendations to improve core social science response capacities, including investments in: human resources within response agencies; the creation of social science data analysis capacities at field and global level; mechanisms for operationalizing knowledge; and a set of rapid deployment infrastructures; 2) Recommendations to strengthen applied and basic social sciences, including the need to: better define the social science agenda and core competencies; support innovative interdisciplinary science; make concerted investments in developing field ready tools and building the evidence-base; and develop codes of conduct; and 3) Recommendations for a supportive social science ecosystem, including: the essential foundational investments in institutional development; training and capacity building; awareness-raising activities with allied disciplines; and lastly, support for a community of practice.\n\nComprehensively integrating social science into the epidemic preparedness and response architecture demands multifaceted investments on par with allied disciplines, such as epidemiology and virology. Building core capacities and competencies should occur at multiple levels, grounded in country-led capacity building. Social science should not be a parallel system, nor should it be \"siloed\" into risk communication and community engagement. Rather, it should be integrated across existing systems and networks, and deploy interdisciplinary knowledge \"transversally\" across all preparedness and response sectors and pillars. Future work should update this framework to account for the impact of the COVID-19 pandemic on the institutional landscape.", "doi": "10.1186/s12992-020-00652-6", "pmid": "33380341", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12992-020-00652-6"}, {"db": "pmc", "key": "PMC7772799"}], "notes": [], "created": "2021-01-07T12:10:19.942Z", "modified": "2021-02-26T08:47:00.083Z"}, {"entity": "publication", "iuid": "af36f6a1c29d4c64bd3c8e3c58546657", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/af36f6a1c29d4c64bd3c8e3c58546657.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/af36f6a1c29d4c64bd3c8e3c58546657"}}, "title": "COVID-19 spatiotemporal research with workflow-based data analysis.", "authors": [{"family": "Chintala", "given": "Srikar", "initials": "S"}, {"family": "Dutta", "given": "Ritvik", "initials": "R"}, {"family": "Tadmor", "given": "Doron", "initials": "D"}], "type": "journal article", "published": "2020-12-30", "journal": {"title": "Infect Genet Evol", "issn": "1567-7257", "volume": null, "issue": null, "pages": "104701", "issn-l": null}, "abstract": "Given the pertinence and acceleration of the spread of COVID-19, there is an increased need for the replicability of data models to verify the veracity of models and visualize important data. Most of these visualizations lack reproducibility, credibility, or accuracy, and are static, which makes it difficult to analyze the spread over time. Furthermore, most current visualizations depicting the spread of COVID-19 are at a global or country level, meaning there is a dearth of regional analysis within a country. Keeping these issues in mind, a replicable, efficient, and simple method to generate regional COVID-19 visualizations mapped with time was created by using the KNIME software, an open-source data analytics platform that can create user-friendly applications or workflows. For this analysis, Albania, Sweden, Ukraine, Denmark, Russia, India, and Australia were closely observed. Among the maps generated for the aforementioned countries, it was noticed that regions with a high population or high population density were often the epicenters within their respective country. The regions caused the virus to spread to their neighboring regions: kickstarting the \"domino effect\", leading to the infection of another region until the country is overwhelmed with cases-what we call a proximity trend. These dynamic maps are crucial to fighting the pandemic because they can provide insight as to how COVID-19 spreads by providing researchers or officials with an accurate and insightful tool to aid their analysis. By being able to visualize the spread, health and government officials can dive deeper to identify the sources of transmission and attempt to stop or reverse them accordingly.", "doi": "10.1016/j.meegid.2020.104701", "pmid": "33387692", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S1567-1348(20)30532-3"}, {"db": "pmc", "key": "PMC7773529"}], "notes": [], "created": "2021-01-07T11:21:45.756Z", "modified": "2021-02-26T08:46:13.433Z"}, {"entity": "publication", "iuid": "2b3f61fe73ac49f0b91cc6fc002bcc7c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2b3f61fe73ac49f0b91cc6fc002bcc7c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2b3f61fe73ac49f0b91cc6fc002bcc7c"}}, "title": "ACE2: the molecular doorway to SARS-CoV-2.", "authors": [{"family": "Medina-Enr\u00edquez", "given": "Miriam Marlene", "initials": "MM"}, {"family": "Lopez-Le\u00f3n", "given": "Sandra", "initials": "S"}, {"family": "Carlos-Escalante", "given": "Jos\u00e9 Alberto", "initials": "JA"}, {"family": "Aponte-Torres", "given": "Zuleika", "initials": "Z"}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Wegman-Ostrosky", "given": "Talia", "initials": "T"}], "type": "journal article", "published": "2020-12-30", "journal": {"title": "Cell Biosci", "issn": "2045-3701", "volume": "10", "issue": "1", "pages": "148", "issn-l": null}, "abstract": "The angiotensin-converting enzyme 2 (ACE2) is the host functional receptor for the new virus SARS-CoV-2 causing Coronavirus Disease 2019. ACE2 is expressed in 72 different cell types. Some factors that can affect the expression of the ACE2 are: sex, environment, comorbidities, medications (e.g. anti-hypertensives) and its interaction with other genes of the renin-angiotensin system and other pathways. Different factors can affect the risk of infection of SARS-CoV-2 and determine the severity of the symptoms. The ACE2 enzyme is a negative regulator of RAS expressed in various organ systems. It is with immunity, inflammation, increased coagulopathy, and cardiovascular disease. In this review, we describe the genetic and molecular functions of the ACE2 receptor and its relation with the physiological and pathological conditions to better understand how this receptor is involved in the pathogenesis of COVID-19. In addition, it reviews the different comorbidities that interact with SARS-CoV-2 in which also ACE2 plays an important role. It also describes the different factors that interact with the virus that have an influence in the expression and functional activities of the receptor. The goal is to provide the reader with an understanding of the complexity and importance of this receptor.", "doi": "10.1186/s13578-020-00519-8", "pmid": "33380340", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13578-020-00519-8"}, {"db": "pmc", "key": "PMC7772801"}], "notes": [], "created": "2021-01-07T12:14:04.788Z", "modified": "2021-01-07T12:14:04.810Z"}, {"entity": "publication", "iuid": "881a0630ec5d4fc8bfdd76a818723b0c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/881a0630ec5d4fc8bfdd76a818723b0c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/881a0630ec5d4fc8bfdd76a818723b0c"}}, "title": "Plasma renin activity has a complex prognostic role in patients with acute coronary syndromes.", "authors": [{"family": "Hartford", "given": "Marianne", "initials": "M"}, {"family": "Herlitz", "given": "Hans", "initials": "H"}, {"family": "Perers", "given": "Elisabeth", "initials": "E"}, {"family": "Karlsson", "given": "Thomas", "initials": "T"}, {"family": "Herlitz", "given": "Johan", "initials": "J"}, {"family": "Persson", "given": "Anita", "initials": "A"}, {"family": "Caidahl", "given": "Kenneth", "initials": "K"}], "type": "journal article", "published": "2020-12-29", "journal": {"title": "Int J Cardiol", "issn": "1874-1754", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Plasma renin activity (PRA) has been related to all-cause mortality and cardiovascular events in patients with cardiovascular disease. However, data from patients with acute coronary syndromes (ACS) are sparse.\r\n\r\nDetermination of PRA was made in 550 patients with ACS, including a subgroup of 287 patients not on treatment with angiotensin converting enzyme inhibitors, angiotensin receptor blockers or diuretics, and without heart failure. We evaluated the relations between PRA and all-cause mortality after three years and long-term, and to cardiovascular events after median 8.7 years. Adjustments were made for variables that influenced the hazard ratio (HR) > 5% for the relation between PRA and outcome.\r\n\r\nBaseline PRA was associated with all-cause mortality during three-years (unadjusted HR 1.74 per 1 SD increase in logarithmically transformed PRA; 95% confidence interval (CI) 1.39-2.16, p < 0.0001) and long-term (HR 1.12, CI 1.00-1.25, p = 0.046). After adjustments, only the three-year association remained significant. In unadjusted analyses, PRA was associated with cardiovascular death, but not with nonfatal cardiovascular events. In the subgroup there was an inverse relation between PRA and long-term all-cause mortality.\r\n\r\nHigher PRA was a significant independent predictor of all-cause mortality after three years, but not at long-term follow-up and not significantly associated with cardiovascular incidence. The renin-angiotensin-system pathophysiology is of great interest, not least due to its association with the COVID-19 pandemic. Our findings indicate a need for further research on the prognostic/predictive aspects of the renin-angiotensin-system in ACS.", "doi": "10.1016/j.ijcard.2020.12.062", "pmid": "33385419", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0167-5273(20)34310-2"}], "notes": [], "created": "2021-01-07T11:37:34.979Z", "modified": "2021-02-26T08:45:48.437Z"}, {"entity": "publication", "iuid": "7d408a34c8ea4368a9fa5d59d4194de1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d408a34c8ea4368a9fa5d59d4194de1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d408a34c8ea4368a9fa5d59d4194de1"}}, "title": "Paediatricians face challenging times as COVID\u201019 can cloud other diagnoses and lead to treatment delays", "authors": [{"family": "Marits", "given": "Ann Katrine", "initials": "AK"}, {"family": "Fischler", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Chromek", "given": "Milan", "initials": "M"}], "type": "journal-article", "published": "2020-12-29", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1111/apa.15725", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-08T09:09:04.389Z", "modified": "2021-02-26T08:45:48.390Z"}, {"entity": "publication", "iuid": "9981ed7c4c3f402ea9ae9ebd7df56738", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9981ed7c4c3f402ea9ae9ebd7df56738.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9981ed7c4c3f402ea9ae9ebd7df56738"}}, "title": "Broadly Active Antiviral Compounds Disturb Zika Virus Progeny Release Rescuing Virus-Induced Toxicity in Brain Organoids.", "authors": [{"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Tampere", "given": "Marianna", "initials": "M"}, {"family": "Pronk", "given": "Robin", "initials": "R"}, {"family": "Wallner", "given": "Olov", "initials": "O"}, {"family": "Falk", "given": "Anna", "initials": "A"}, {"family": "Warpman Berglund", "given": "Ulrika", "initials": "U"}, {"family": "Helleday", "given": "Thomas", "initials": "T"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Puumalainen", "given": "Marjo-Riitta", "initials": "MR"}], "type": "journal article", "published": "2020-12-29", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "1", "pages": "37", "issn-l": "1999-4915"}, "abstract": "RNA viruses have gained plenty of attention during recent outbreaks of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Zika virus (ZIKV), and Ebola virus. ZIKV is a vector borne Flavivirus that is spread by mosquitoes and it mainly infects neuronal progenitor cells. One hallmark of congenital ZIKV disease is a reduced brain size in fetuses, leading to severe neurological defects. The World Health Organization (WHO) is urging the development of new antiviral treatments against ZIKV, as there are no efficient countermeasures against ZIKV disease. Previously, we presented a new class of host-targeting antivirals active against a number of pathogenic RNA viruses, such as SARS-CoV-2. Here, we show the transfer of the image-based phenotypic antiviral assay to ZIKV-infected brain cells, followed by mechanism-of-action studies and a proof-of-concept study in a three-dimensional (3D) organoid model. The novel antiviral compounds showed a therapeutic window against ZIKV in several cell models and rescued ZIKV-induced neurotoxicity in brain organoids. The compound's mechanism-of-action was pinpointed to late steps in the virus life cycle, impairing the formation of new virus particles. Collectively, in this study, we expand the antiviral activity of new small molecule inhibitors to a new virus class of Flaviviruses, but also uncover compounds' mechanism of action, which are important for the further development of antivirals.", "doi": "10.3390/v13010037", "pmid": "33383826", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: H2020": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "v13010037"}, {"db": "URL", "key": "https://www.mdpi.com/1999-4915/13/1/37/s1", "description": "The effect of novel antiviral compounds against ZIKV in several cell models; other supporting data"}], "notes": [], "created": "2021-01-07T11:49:35.800Z", "modified": "2021-02-26T08:45:03.173Z"}, {"entity": "publication", "iuid": "e990290ae5f6422b9b724ae8ee6e58e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e990290ae5f6422b9b724ae8ee6e58e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e990290ae5f6422b9b724ae8ee6e58e1"}}, "title": "Seropositivity in blood donors and pregnant women during 9-months of SARS-CoV-2 transmission in Stockholm, Sweden", "authors": [{"family": "Dopico", "given": "Xaquin Castro", "initials": "XC"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Christian", "given": "Murray", "initials": "M"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Grinberg", "given": "Nastasiya F", "initials": "NF"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Mcinerney", "given": "Gerald M", "initials": "GM"}, {"family": "Allander", "given": "Tobias", "initials": "T"}, {"family": "Wallace", "given": "Chris", "initials": "C"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}], "type": "posted-content", "published": "2020-12-26", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.24.20248821", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Funder: H2020": null, "Category: Health": null, "Category: Serology": null}, "xrefs": [{"db": "URL", "key": "https://github.com/MurrellGroup/DiscriminativeSeroprevalence/", "description": "Data and analysis code (Ben Murrell Group)"}, {"db": "URL", "key": "https://github.com/chr1swallace/seroprevalence-paper", "description": "Data and analysis code (Chris Wallace Group)"}], "notes": [], "created": "2021-01-07T16:43:04.878Z", "modified": "2021-04-23T09:09:33.692Z"}, {"entity": "publication", "iuid": "3aeb13b25a9d4e3da6ffa6db5a446fe7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3aeb13b25a9d4e3da6ffa6db5a446fe7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3aeb13b25a9d4e3da6ffa6db5a446fe7"}}, "title": "Adverse effects of hydroxychloroquine and azithromycin on contractility and arrhythmogenicity revealed by human engineered cardiac tissues.", "authors": [{"family": "Wong", "given": "Andy On-Tik", "initials": "AO"}, {"family": "Gurung", "given": "Bimal", "initials": "B"}, {"family": "Wong", "given": "Wing Sum", "initials": "WS"}, {"family": "Mak", "given": "Suet Yee", "initials": "SY"}, {"family": "Tse", "given": "Wan Wai", "initials": "WW"}, {"family": "Li", "given": "Chloe M", "initials": "CM"}, {"family": "Lieu", "given": "Deborah K", "initials": "DK"}, {"family": "Costa", "given": "Kevin D", "initials": "KD"}, {"family": "Li", "given": "Ronald A", "initials": "RA"}, {"family": "Hajjar", "given": "Roger J", "initials": "RJ"}], "type": "journal article", "published": "2020-12-26", "journal": {"title": "J Mol Cell Cardiol", "issn": "1095-8584", "volume": "153", "issue": null, "pages": "106-110", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic as declared by World Health Organization (WHO). In the absence of an effective treatment in early 2020, different drugs with unknown effectiveness, including antimalarial hydroxychloroquine (HCQ), with or without concurrent administration with azithromycin (AZM), have been tested for treating COVID-19 patients with developed pneumonia. However, the efficacy and safety of HCQ and/or AZM have been questioned by recent clinical reports. Direct effects of these drugs on the human heart remain very poorly defined. To better understand the mechanisms of action of HCQ +/- AZM, we employed bioengineered human ventricular cardiac tissue strip (hvCTS) and anisotropic sheet (hvCAS) assays, made with human pluripotent stem cell (hPSC)-derived ventricular cardiomyocytes (hvCMs), which have been designed for measuring cardiac contractility and electrophysiology, respectively. Our hvCTS experiments showed that AZM induced a dose-dependent negative inotropic effect which could be aggravated by HCQ; electrophysiologically, as revealed by the hvCAS platform, AZM prolonged action potentials and induced spiral wave formations. Collectively, our data were consistent with reported clinical risks of HCQ and AZM on QTc prolongation/ventricular arrhythmias and development of heart failure. In conclusion, our study exposed the risks of HCQ/AZM administration while providing mechanistic insights for their toxicity. Our bioengineered human cardiac tissue constructs therefore provide a useful platform for screening cardiac safety and efficacy when developing therapeutics against COVID-19.", "doi": "10.1016/j.yjmcc.2020.12.014", "pmid": "33373642", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S0022-2828(20)30354-0"}, {"db": "pmc", "key": "PMC7765761"}], "notes": [], "created": "2021-01-07T12:32:02.760Z", "modified": "2021-02-26T08:45:25.850Z"}, {"entity": "publication", "iuid": "13a67022e71646239744a33435e1b112", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13a67022e71646239744a33435e1b112.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13a67022e71646239744a33435e1b112"}}, "title": "Risk of depression, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: a multinational network cohort study.", "authors": [{"family": "Lane", "given": "Jennifer C E", "initials": "JCE"}, {"family": "Weaver", "given": "James", "initials": "J"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "Abrahao", "given": "Maria Tereza F", "initials": "MTF"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Biedermann", "given": "Patricia", "initials": "P"}, {"family": "Banda", "given": "Juan M", "initials": "JM"}, {"family": "Burn", "given": "Edward", "initials": "E"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "Fister", "given": "Kristina", "initials": "K"}, {"family": "Hardin", "given": "Jill", "initials": "J"}, {"family": "Hester", "given": "Laura", "initials": "L"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Kaas-Hansen", "given": "Benjamin Skov", "initials": "BS"}, {"family": "Khosla", "given": "Sajan", "initials": "S"}, {"family": "Kolovos", "given": "Spyros", "initials": "S"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Makadia", "given": "Rupa", "initials": "R"}, {"family": "Mehta", "given": "Paras P", "initials": "PP"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Morgan-Stewart", "given": "Henry", "initials": "H"}, {"family": "Mosseveld", "given": "Mees", "initials": "M"}, {"family": "Newby", "given": "Danielle", "initials": "D"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Woong Park", "given": "Rae", "initials": "R"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A"}, {"family": "Rao", "given": "Gowtham A", "initials": "GA"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Rijnbeek", "given": "Peter", "initials": "P"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Shoaibi", "given": "Azza", "initials": "A"}, {"family": "Spotnitz", "given": "Matthew", "initials": "M"}, {"family": "Vignesh", "given": "Subbian", "initials": "S"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Vizcaya", "given": "David", "initials": "D"}, {"family": "Wen", "given": "Haini", "initials": "H"}, {"family": "de Wilde", "given": "Marcel", "initials": "M"}, {"family": "Xie", "given": "Junqing", "initials": "J"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Lovestone", "given": "Simon", "initials": "S"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "OHDSI-COVID-19 consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2020-12-25", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "volume": null, "issue": null, "issn-l": null}, "abstract": "Concern has been raised in the rheumatology community regarding recent regulatory warnings that HCQ used in the coronavirus disease 2019 pandemic could cause acute psychiatric events. We aimed to study whether there is risk of incident depression, suicidal ideation or psychosis associated with HCQ as used for RA.\n\nWe performed a new-user cohort study using claims and electronic medical records from 10 sources and 3 countries (Germany, UK and USA). RA patients \u226518 years of age and initiating HCQ were compared with those initiating SSZ (active comparator) and followed up in the short (30 days) and long term (on treatment). Study outcomes included depression, suicide/suicidal ideation and hospitalization for psychosis. Propensity score stratification and calibration using negative control outcomes were used to address confounding. Cox models were fitted to estimate database-specific calibrated hazard ratios (HRs), with estimates pooled where I2 <40%.\n\nA total of 918 144 and 290 383 users of HCQ and SSZ, respectively, were included. No consistent risk of psychiatric events was observed with short-term HCQ (compared with SSZ) use, with meta-analytic HRs of 0.96 (95% CI 0.79, 1.16) for depression, 0.94 (95% CI 0.49, 1.77) for suicide/suicidal ideation and 1.03 (95% CI 0.66, 1.60) for psychosis. No consistent long-term risk was seen, with meta-analytic HRs of 0.94 (95% CI 0.71, 1.26) for depression, 0.77 (95% CI 0.56, 1.07) for suicide/suicidal ideation and 0.99 (95% CI 0.72, 1.35) for psychosis.\n\nHCQ as used to treat RA does not appear to increase the risk of depression, suicide/suicidal ideation or psychosis compared with SSZ. No effects were seen in the short or long term. Use at a higher dose or for different indications needs further investigation.\n\nRegistered with EU PAS (reference no. EUPAS34497; http://www.encepp.eu/encepp/viewResource.htm? id=34498). The full study protocol and analysis source code can be found at https://github.com/ohdsi-studies/Covid19EstimationHydroxychloroquine2.", "doi": "10.1093/rheumatology/keaa771", "pmid": "33367863", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://github.com/ohdsi-studies/Covid19EstimationHydroxychloroquine2", "description": "Data aggregated by data source"}], "notes": [], "created": "2021-01-07T13:36:58.823Z", "modified": "2021-04-26T17:59:42.486Z"}, {"entity": "publication", "iuid": "6add60296d9a47959698548642400e61", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6add60296d9a47959698548642400e61.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6add60296d9a47959698548642400e61"}}, "title": "Recent smell loss is the best predictor of COVID-19 among individuals with recent respiratory symptoms", "authors": [{"family": "Gerkin", "given": "Richard C", "initials": "RC"}, {"family": "Ohla", "given": "Kathrin", "initials": "K"}, {"family": "Veldhuizen", "given": "Maria G", "initials": "MG"}, {"family": "Joseph", "given": "Paule V", "initials": "PV"}, {"family": "Kelly", "given": "Christine E", "initials": "CE"}, {"family": "Bakke", "given": "Alyssa J", "initials": "AJ"}, {"family": "Steele", "given": "Kimberley E", "initials": "KE"}, {"family": "Farruggia", "given": "Michael C", "initials": "MC"}, {"family": "Pellegrino", "given": "Robert", "initials": "R"}, {"family": "Pepino", "given": "Marta Y", "initials": "MY"}, {"family": "Bouysset", "given": "C\u00e9dric", "initials": "C"}, {"family": "Soler", "given": "Graciela M", "initials": "GM"}, {"family": "Pereda-Loth", "given": "Veronica", "initials": "V"}, {"family": "Dibattista", "given": "Michele", "initials": "M"}, {"family": "Cooper", "given": "Keiland W", "initials": "KW"}, {"family": "Croijmans", "given": "Ilja", "initials": "I"}, {"family": "Di Pizio", "given": "Antonella", "initials": "A"}, {"family": "Ozdener", "given": "M Hakan", "initials": "MH"}, {"family": "Fjaeldstad", "given": "Alexander W", "initials": "AW"}, {"family": "Lin", "given": "Cailu", "initials": "C"}, {"family": "Sandell", "given": "Mari A", "initials": "MA"}, {"family": "Singh", "given": "Preet B", "initials": "PB"}, {"family": "Brindha", "given": "V Evelyn", "initials": "VE"}, {"family": "Olsson", "given": "Shannon B", "initials": "SB"}, {"family": "Saraiva", "given": "Luis R", "initials": "LR"}, {"family": "Ahuja", "given": "Gaurav", "initials": "G"}, {"family": "Alwashahi", "given": "Mohammed K", "initials": "MK"}, {"family": "Bhutani", "given": "Surabhi", "initials": "S"}, {"family": "D\u2019Errico", "given": "Anna", "initials": "A"}, {"family": "Fornazieri", "given": "Marco A", "initials": "MA"}, {"family": "Golebiowski", "given": "J\u00e9r\u00f4me", "initials": "J"}, {"family": "Hwang", "given": "Liang Dar", "initials": "LD"}, {"family": "\u00d6zt\u00fcrk", "given": "Lina", "initials": "L"}, {"family": "Roura", "given": "Eugeni", "initials": "E"}, {"family": "Spinelli", "given": "Sara", "initials": "S"}, {"family": "Whitcroft", "given": "Katherine L", "initials": "KL"}, {"family": "Faraji", "given": "Farhoud", "initials": "F"}, {"family": "Fischmeister", "given": "Florian PhS", "initials": "FP"}, {"family": "Heinbockel", "given": "Thomas", "initials": "T"}, {"family": "Hsieh", "given": "Julien W", "initials": "JW"}, {"family": "Huart", "given": "Caroline", "initials": "C"}, {"family": "Konstantinidis", "given": "Iordanis", "initials": "I"}, {"family": "Menini", "given": "Anna", "initials": "A"}, {"family": "Morini", "given": "Gabriella", "initials": "G"}, {"family": "Olofsson", "given": "Jonas K", "initials": "JK"}, {"family": "Philpott", "given": "Carl M", "initials": "CM"}, {"family": "Pierron", "given": "Denis", "initials": "D"}, {"family": "Shields", "given": "Vonnie D C", "initials": "VDC"}, {"family": "Voznessenskaya", "given": "Vera V", "initials": "VV"}, {"family": "Albayay", "given": "Javier", "initials": "J"}, {"family": "Altundag", "given": "Aytug", "initials": "A"}, {"family": "Bensafi", "given": "Moustafa", "initials": "M"}, {"family": "Bock", "given": "Mar\u00eda Adelaida", "initials": "MA"}, {"family": "Calcinoni", "given": "Orietta", "initials": "O"}, {"family": "Fredborg", "given": "William", "initials": "W"}, {"family": "Laudamiel", "given": "Christophe", "initials": "C"}, {"family": "Lim", "given": "Juyun", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Johan N", "initials": "JN"}, {"family": "Macchi", "given": "Alberto", "initials": "A"}, {"family": "Meyer", "given": "Pablo", "initials": "P"}, {"family": "Moein", "given": "Shima T", "initials": "ST"}, {"family": "Santamar\u00eda", "given": "Enrique", "initials": "E"}, {"family": "Sengupta", "given": "Debarka", "initials": "D"}, {"family": "Dominguez", "given": "Paloma Rohlfs", "initials": "PR"}, {"family": "Yanik", "given": "H\u00fcseyin", "initials": "H"}, {"family": "Hummel", "given": "Thomas", "initials": "T"}, {"family": "Hayes", "given": "John E", "initials": "JE"}, {"family": "Reed", "given": "Danielle R", "initials": "DR"}, {"family": "Niv", "given": "Masha Y", "initials": "MY"}, {"family": "Munger", "given": "Steven D", "initials": "SD"}, {"family": "Parma", "given": "Valentina", "initials": "V"}, {"family": "Boesveldt", "given": "Sanne", "initials": "S"}, {"family": "de Groot", "given": "Jasper H B", "initials": "JHB"}, {"family": "Dinnella", "given": "Caterina", "initials": "C"}, {"family": "Freiherr", "given": "Jessica", "initials": "J"}, {"family": "Laktionova", "given": "Tatiana", "initials": "T"}, {"family": "Marino", "given": "Sajidxa", "initials": "S"}, {"family": "Monteleone", "given": "Erminio", "initials": "E"}, {"family": "Nunez-Parra", "given": "Alexia", "initials": "A"}, {"family": "Abdulrahman", "given": "Olagunju", "initials": "O"}, {"family": "Ritchie", "given": "Marina", "initials": "M"}, {"family": "Thomas-Danguin", "given": "Thierry", "initials": "T"}, {"family": "Walsh-Messinger", "given": "Julie", "initials": "J"}, {"family": "Al Abri", "given": "Rashid", "initials": "R"}, {"family": "Alizadeh", "given": "Rafieh", "initials": "R"}, {"family": "Bignon", "given": "Emmanuelle", "initials": "E"}, {"family": "Cantone", "given": "Elena", "initials": "E"}, {"family": "Cecchini", "given": "Maria Paola", "initials": "MP"}, {"family": "Chen", "given": "Jingguo", "initials": "J"}, {"family": "Gu\u00e0rdia", "given": "Maria Dolors", "initials": "MD"}, {"family": "Hoover", "given": "Kara C", "initials": "KC"}, {"family": "Karni", "given": "Noam", "initials": "N"}, {"family": "Navarro", "given": "Marta", "initials": "M"}, {"family": "Nolden", "given": "Alissa A", "initials": "AA"}, {"family": "Mazal", "given": "Patricia Portillo", "initials": "PP"}, {"family": "Rowan", "given": "Nicholas R", "initials": "NR"}, {"family": "Sarabi-Jamab", "given": "Atiye", "initials": "A"}, {"family": "Archer", "given": "Nicholas S", "initials": "NS"}, {"family": "Chen", "given": "Ben", "initials": "B"}, {"family": "Di Valerio", "given": "Elizabeth A", "initials": "EA"}, {"family": "Feeney", "given": "Emma L", "initials": "EL"}, {"family": "Frasnelli", "given": "Johannes", "initials": "J"}, {"family": "Hannum", "given": "Mackenzie E", "initials": "ME"}, {"family": "Hopkins", "given": "Claire", "initials": "C"}, {"family": "Klein", "given": "Hadar", "initials": "H"}, {"family": "Mignot", "given": "Coralie", "initials": "C"}, {"family": "Mucignat", "given": "Carla", "initials": "C"}, {"family": "Ning", "given": "Yuping", "initials": "Y"}, {"family": "Ozturk", "given": "Elif E", "initials": "EE"}, {"family": "Peng", "given": "Mei", "initials": "M"}, {"family": "Saatci", "given": "Ozlem", "initials": "O"}, {"family": "Sell", "given": "Elizabeth A", "initials": "EA"}, {"family": "Yan", "given": "Carol H", "initials": "CH"}, {"family": "Alfaro", "given": "Raul", "initials": "R"}, {"family": "Cecchetto", "given": "Cinzia", "initials": "C"}, {"family": "Coureaud", "given": "G\u00e9rard", "initials": "G"}, {"family": "Herriman", "given": "Riley D", "initials": "RD"}, {"family": "Justice", "given": "Jeb M", "initials": "JM"}, {"family": "Kaushik", "given": "Pavan Kumar", "initials": "PK"}, {"family": "Koyama", "given": "Sachiko", "initials": "S"}, {"family": "Overdevest", "given": "Jonathan B", "initials": "JB"}, {"family": "Pirastu", "given": "Nicola", "initials": "N"}, {"family": "Ramirez", "given": "Vicente A", "initials": "VA"}, {"family": "Roberts", "given": "S Craig", "initials": "SC"}, {"family": "Smith", "given": "Barry C", "initials": "BC"}, {"family": "Cao", "given": "Hongyuan", "initials": "H"}, {"family": "Wang", "given": "Hong", "initials": "H"}, {"family": "Birindwa", "given": "Patrick Balungwe", "initials": "PB"}, {"family": "Baguma", "given": "Marius", "initials": "M"}, {"family": null, "given": "", "initials": ""}], "type": "journal-article", "published": "2020-12-25", "journal": {"title": "Chem Senses", "issn": "0379-864X", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1093/chemse/bjaa081", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-07T13:27:02.579Z", "modified": "2021-02-26T08:45:48.282Z"}, {"entity": "publication", "iuid": "58d80771ef804c749a527a139bb4267e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/58d80771ef804c749a527a139bb4267e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/58d80771ef804c749a527a139bb4267e"}}, "title": "Practical recommendations for the management of patients with gastroenteropancreatic and thoracic (carcinoid) neuroendocrine neoplasms in the COVID-19 era.", "authors": [{"family": "Rodriguez-Freixinos", "given": "V\u00edctor", "initials": "V"}, {"family": "Capdevila", "given": "Jaume", "initials": "J"}, {"family": "Pavel", "given": "Marianne", "initials": "M"}, {"family": "Thawer", "given": "Alia", "initials": "A"}, {"family": "Baudin", "given": "Eric", "initials": "E"}, {"family": "O'Toole", "given": "Dermot", "initials": "D"}, {"family": "Herrmann", "given": "Ken", "initials": "K"}, {"family": "Welin", "given": "Staffan", "initials": "S"}, {"family": "Grozinsky-Glasberg", "given": "Simona", "initials": "S"}, {"family": "de Herder", "given": "Wouter W", "initials": "WW"}, {"family": "Valle", "given": "Juan W", "initials": "JW"}, {"family": "Herman", "given": "Jackie", "initials": "J"}, {"family": "Kolarova", "given": "Teodora", "initials": "T"}, {"family": "Bouvier", "given": "Catherine", "initials": "C"}, {"family": "Falconi", "given": "Massimo", "initials": "M"}, {"family": "Ferone", "given": "Diego", "initials": "D"}, {"family": "Singh", "given": "Simron", "initials": "S"}], "type": "journal article", "published": "2020-12-25", "journal": {"title": "Eur J Cancer", "issn": "1879-0852", "volume": "144", "issue": null, "pages": "200-214", "issn-l": "0959-8049"}, "abstract": "Neuroendocrine neoplasms (NENs) are a heterogeneous family of uncommon tumours with challenging diagnosis, clinical management and unique needs that almost always requires a multidisciplinary approach. In the absence of guidance from the scientific literature, along with the rapidly changing data available on the effect of COVID-19, we report how 12 high-volume NEN centres of expertise in 10 countries at different stages of the evolving COVID-19 global pandemic along with members of international neuroendocrine cancer patient societies have suggested to preserve high standards of care for patients with NENs. We review the multidisciplinary management of neuroendocrine neoplasms during the COVID-19 pandemic, and we suggest potential strategies to reduce risk and aid multidisciplinary treatment decision-making. By sharing our joint experiences, we aim to generate recommendations for proceeding to other institutions facing the same challenges.", "doi": "10.1016/j.ejca.2020.11.037", "pmid": "33370645", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0959-8049(20)31374-5"}], "notes": [], "created": "2021-01-07T13:13:58.912Z", "modified": "2021-01-07T13:13:58.922Z"}, {"entity": "publication", "iuid": "52346200eaa64ea0a9b13640d47de9e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/52346200eaa64ea0a9b13640d47de9e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/52346200eaa64ea0a9b13640d47de9e2"}}, "title": "Interassociation consensus recommendations for pitch-side emergency care and personal protective equipment for elite sport during the COVID-19 pandemic.", "authors": [{"family": "Hodgson", "given": "Lisa", "initials": "L"}, {"family": "Phillips", "given": "Gemma", "initials": "G"}, {"family": "Gordon", "given": "Jonathan", "initials": "J"}, {"family": "Hanson", "given": "Jonathan", "initials": "J"}, {"family": "Maclean", "given": "John", "initials": "J"}, {"family": "Mathema", "given": "Prabhat", "initials": "P"}, {"family": "Smith", "given": "Andrew", "initials": "A"}, {"family": "Woolcock", "given": "Mark", "initials": "M"}, {"family": "Cowie", "given": "Charlotte M", "initials": "CM"}, {"family": "Kemp", "given": "Simon", "initials": "S"}, {"family": "Patterson", "given": "Michael", "initials": "M"}, {"family": "Larkin", "given": "Jo", "initials": "J"}, {"family": "Hill", "given": "Jerry", "initials": "J"}, {"family": "Rossiter", "given": "Michael", "initials": "M"}, {"family": "Elliott", "given": "Niall", "initials": "N"}, {"family": "Bennett", "given": "Pippa", "initials": "P"}, {"family": "Power", "given": "Jonathan", "initials": "J"}, {"family": "Pillay", "given": "Ari", "initials": "A"}, {"family": "Singh", "given": "Harjinder", "initials": "H"}, {"family": "Sheridan", "given": "Craig", "initials": "C"}, {"family": "Hurwood", "given": "Matthew", "initials": "M"}, {"family": "Riou", "given": "Peter", "initials": "P"}, {"family": "Bennison", "given": "Anthony", "initials": "A"}, {"family": "Chakraverty", "given": "Susan", "initials": "S"}, {"family": "Tingay", "given": "Richard", "initials": "R"}, {"family": "Higgins", "given": "Richard", "initials": "R"}, {"family": "Weiler", "given": "Richard", "initials": "R"}, {"family": "Jaques", "given": "Rod", "initials": "R"}, {"family": "Spencer", "given": "Simon", "initials": "S"}, {"family": "Carmont", "given": "Michael R", "initials": "MR"}, {"family": "Patricios", "given": "Jon", "initials": "J"}], "type": "journal article", "published": "2020-12-24", "journal": {"title": "Br J Sports Med", "issn": "1473-0480", "volume": null, "issue": null, "pages": "bjsports-2020-103226", "issn-l": null}, "abstract": "The COVID-19 pandemic has necessitated many novel responses in healthcare including sport and exercise medicine. The cessation of elite sport almost globally has had significant economic implications and resulted in pressure to resume sport in very controlled conditions. This includes protecting pitch-side medical staff and players from infection. The ongoing prevalence of SARS-CoV-2 and the desire to resume professional sport required urgent best practice guidelines to be developed so that sport could be resumed as safely as possible. This set of best practice recommendations assembles early evidence for managing SARS-CoV-2 and integrates expert opinion to provide a uniform and pragmatic approach to enhance on-field and pitch-side safety for the clinician and player. The nature of SARS-CoV-2 transmission creates new hazards during resuscitation and emergency care and procedures. Recommendations for the use and type of personal protective equipment during on-field or pitch-side emergency medical care is provided based on the clinical scenario and projected risk of viral transmission.", "doi": "10.1136/bjsports-2020-103226", "pmid": "33361278", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bjsports-2020-103226"}, {"db": "pmc", "key": "PMC7768617"}], "notes": [], "created": "2021-01-07T13:43:34.897Z", "modified": "2021-01-10T17:27:46.284Z"}, {"entity": "publication", "iuid": "3b90f2b1a6614f01a77d54eccf59c5fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3b90f2b1a6614f01a77d54eccf59c5fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3b90f2b1a6614f01a77d54eccf59c5fd"}}, "title": "Doctor at Your Fingertips: An Exploration of Digital Visits from Stakeholders' Perspectives.", "authors": [{"family": "Demi", "given": "Selina", "initials": "S"}, {"family": "Hilmy", "given": "Samir", "initials": "S"}, {"family": "Keller", "given": "Christina", "initials": "C"}], "type": "journal article", "published": "2020-12-24", "journal": {"title": "Life (Basel)", "issn": "2075-1729", "volume": "11", "issue": "1", "issn-l": null}, "abstract": "Technological advances and the evolution of mobile technologies enable patients to meet their doctors through their smartphones. While offering the opportunity of digital visits to patients, there are also challenges for this development. The purpose of this study is to enhance the understanding of digital visits, as perceived by experts working in telemedicine companies. To serve this purpose, the authors conducted semi-structured interviews with managers and employees in eight telemedicine companies. The analysis of the empirical data confirmed the importance of digital visits and their efficiency. The potential of digital visits is expected to increase significantly, should they make use of remote devices to transfer real-time data from patients to physicians. In such a case, digital visits are expected to cover approximately 70-75% of medical cases. However, the use of remote devices must be taken with caution and specific conditions need to be taken into account. We encourage researchers to perform research on promising technologies such as artificial intelligence and remote diagnostic devices, which could make more diagnoses and conditions possible to be treated by digital visits. This is even more important in light of the ongoing Covid-19 pandemic.", "doi": "10.3390/life11010006", "pmid": "33374106", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "life11010006"}], "notes": [], "created": "2021-01-07T12:16:55.160Z", "modified": "2021-02-26T08:46:59.920Z"}, {"entity": "publication", "iuid": "6f875a8ff1de4906add4110bf19cb5b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f875a8ff1de4906add4110bf19cb5b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f875a8ff1de4906add4110bf19cb5b3"}}, "title": "Improving Hospital Oxygen Systems for COVID-19 in Low-Resource Settings: Lessons From the Field", "authors": [{"family": "Graham", "given": "Hamish R", "initials": "HR"}, {"family": "Bagayana", "given": "Sheillah M", "initials": "SM"}, {"family": "Bakare", "given": "Ayobami A", "initials": "AA"}, {"family": "Olayo", "given": "Bernard O", "initials": "BO"}, {"family": "Peterson", "given": "Stefan S", "initials": "SS"}, {"family": "Duke", "given": "Trevor", "initials": "T"}, {"family": "Falade", "given": "Adegoke G", "initials": "AG"}], "type": "journal-article", "published": "2020-12-23", "journal": {"title": "Glob Health Sci Pract", "issn": "2169-575X", "volume": "8", "issue": "4", "pages": "858-862", "issn-l": null}, "abstract": "Oxygen therapy is an essential medicine and core component of effective hospital systems. However, many hospitals in low- and middle-income countries lack reliable oxygen access-a deficiency highlighted and exacerbated by the coronavirus disease (COVID-19) pandemic. Oxygen access can be challenged by equipment that is low quality and poorly maintained, lack of clinical and technical training and protocols, and deficiencies in local infrastructure and policy environment. We share learnings from 2 decades of oxygen systems work with hospitals in Africa and the Asia-Pacific regions, highlighting practical actions that hospitals can take to immediately expand oxygen access. These include strategies to: (1) improve pulse oximetry and oxygen use, (2) support biomedical engineers to optimize existing oxygen supplies, and (3) expand on existing oxygen systems with robust equipment and smart design. We make all our resources freely available for use and local adaptation.", "doi": "10.9745/ghsp-d-20-00224", "pmid": "33361248", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-10T17:28:22.586Z", "modified": "2021-02-26T08:45:48.299Z"}, {"entity": "publication", "iuid": "109ae59a123f4d558105cb7048e44995", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/109ae59a123f4d558105cb7048e44995.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/109ae59a123f4d558105cb7048e44995"}}, "title": "Spices to Control COVID-19 Symptoms: Yes, but Not Only\u2026.", "authors": [{"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Czarlewski", "given": "Wienczyslawa", "initials": "W"}, {"family": "Zuberbier", "given": "Torsten", "initials": "T"}, {"family": "Mullol", "given": "Joaquim", "initials": "J"}, {"family": "Blain", "given": "Hubert", "initials": "H"}, {"family": "Cristol", "given": "Jean-Paul", "initials": "JP"}, {"family": "De La Torre", "given": "Rafael", "initials": "R"}, {"family": "Le Moing", "given": "Vincent", "initials": "V"}, {"family": "Pizarro Lozano", "given": "Nieves", "initials": "N"}, {"family": "Bedbrook", "given": "Anna", "initials": "A"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Akdis", "given": "Cezmi A", "initials": "CA"}, {"family": "Canonica", "given": "G Walter", "initials": "GW"}, {"family": "Cruz", "given": "Alvaro A", "initials": "AA"}, {"family": "Fiocchi", "given": "Alessandro", "initials": "A"}, {"family": "Fonseca", "given": "Joao A", "initials": "JA"}, {"family": "Fonseca", "given": "Susana", "initials": "S"}, {"family": "Gemicio\u011flu", "given": "Bilun", "initials": "B"}, {"family": "Haahtela", "given": "Tari", "initials": "T"}, {"family": "Iaccarino", "given": "Guido", "initials": "G"}, {"family": "Ivancevich", "given": "Juan Carlos", "initials": "JC"}, {"family": "Jutel", "given": "Marek", "initials": "M"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Kuna", "given": "Piotr", "initials": "P"}, {"family": "Larenas-Linnemann", "given": "D\u00e9sir\u00e9e E", "initials": "DE"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Okamoto", "given": "Yoshitaka", "initials": "Y"}, {"family": "Papadopoulos", "given": "Nikolaos G", "initials": "NG"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Reynes", "given": "Jacques", "initials": "J"}, {"family": "Rolland", "given": "Yves", "initials": "Y"}, {"family": "Rouadi", "given": "Philip W", "initials": "PW"}, {"family": "Samolinski", "given": "Boleslaw", "initials": "B"}, {"family": "Sheikh", "given": "Aziz", "initials": "A"}, {"family": "Toppila-Salmi", "given": "Sanna", "initials": "S"}, {"family": "Valiulis", "given": "Arunas", "initials": "A"}, {"family": "Choi", "given": "Hak-Jong", "initials": "HJ"}, {"family": "Kim", "given": "Hyun Ju", "initials": "HJ"}, {"family": "Anto", "given": "Josep M", "initials": "JM"}], "type": "journal article", "published": "2020-12-22", "journal": {"title": "Int Arch Allergy Immunol", "issn": "1018-2438", "volume": "182", "issue": "6", "pages": "489-495", "issn-l": null}, "abstract": "There are large country variations in COVID-19 death rates that may be partly explained by diet. Many countries with low COVID-19 death rates have a common feature of eating large quantities of fermented vegetables such as cabbage and, in some continents, various spices. Fermented vegetables and spices are agonists of the antioxidant transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and spices are transient receptor potential ankyrin 1 and vanillin 1 (TRPA1/V1) agonists. These mechanisms may explain many COVID-19 symptoms and severity. It appears that there is a synergy between Nrf2 and TRPA1/V1 foods that may explain the role of diet in COVID-19. One of the mechanisms of COVID-19 appears to be an oxygen species (ROS)-mediated process in synergy with TRP channels, modulated by Nrf2 pathways. Spicy foods are likely to desensitize TRP channels and act in synergy with exogenous antioxidants that activate the Nrf2 pathway.", "doi": "10.1159/000513538", "pmid": "33352565", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "000513538"}, {"db": "pmc", "key": "PMC7900475"}], "notes": [], "created": "2021-01-08T08:23:27.711Z", "modified": "2021-07-14T07:52:46.595Z"}, {"entity": "publication", "iuid": "61cc72674c1b4238a17acd0e8258e2fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61cc72674c1b4238a17acd0e8258e2fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61cc72674c1b4238a17acd0e8258e2fd"}}, "title": "Sex and age differences in COVID-19 mortality in Europe", "authors": [{"family": "Ahrenfeldt", "given": "Linda Juel", "initials": "LJ"}, {"family": "Otavova", "given": "Martina", "initials": "M"}, {"family": "Christensen", "given": "Kaare", "initials": "K"}, {"family": "Lindahl-Jacobsen", "given": "Rune", "initials": "R"}], "type": "journal-article", "published": "2020-12-22", "journal": {"title": "Wien Klin Wochenschr", "issn": "0043-5325", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1007/s00508-020-01793-9", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-10T17:35:36.357Z", "modified": "2021-02-26T08:46:59.983Z"}, {"entity": "publication", "iuid": "e1e465b949a64f3ab9edb94f803cc998", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e1e465b949a64f3ab9edb94f803cc998.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e1e465b949a64f3ab9edb94f803cc998"}}, "title": "Potentially Prolonged Psychological Distress from Postponed Olympic and Paralympic Games during COVID-19-Career Uncertainty in Elite Athletes.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "Moesch", "given": "Karin", "initials": "K"}, {"family": "J\u00f6nsson", "given": "Caroline", "initials": "C"}, {"family": "Kentt\u00e4", "given": "G\u00f6ran", "initials": "G"}], "type": "journal article", "published": "2020-12-22", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "18", "issue": "1", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on the world of sports due to periods of home quarantine, bans against public gatherings, travel restrictions, and a large number of postponed or canceled major sporting events. The literature hitherto is sparse, but early indications display signs of psychological impact on elite athletes due to the pandemic. However, beyond acute effects from lockdown and short-term interrupted athletic seasons, the postponed and still uncertain Olympic and Paralympic Games may represent a major career insecurity to many athletes world-wide, and may lead to severe changes to everyday lives and potentially prolonged psychological distress. Given the long-term perspective of these changes, researchers and stakeholders should address mental health and long-term job insecurity in athletes, including a specific focus on those with small financial margins, such as many female athletes, parasports athletes, athletes in smaller sports, and athletes from developing countries. Implications and the need for research are discussed.", "doi": "10.3390/ijerph18010002", "pmid": "33374935", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph18010002"}], "notes": [], "created": "2021-01-07T12:14:31.841Z", "modified": "2021-02-26T08:47:00.247Z"}, {"entity": "publication", "iuid": "a99f54c3366840b9b773368a79f5ae97", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a99f54c3366840b9b773368a79f5ae97.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a99f54c3366840b9b773368a79f5ae97"}}, "title": "Modelling the effect of the COVID-19 pandemic on violent discipline against children.", "authors": [{"family": "Fabbri", "given": "Camilla", "initials": "C"}, {"family": "Bhatia", "given": "Amiya", "initials": "A"}, {"family": "Petzold", "given": "Max", "initials": "M"}, {"family": "Jugder", "given": "Munkhbadar", "initials": "M"}, {"family": "Guedes", "given": "Alessandra", "initials": "A"}, {"family": "Cappa", "given": "Claudia", "initials": "C"}, {"family": "Devries", "given": "Karen", "initials": "K"}], "type": "journal article", "published": "2020-12-22", "journal": {"title": "Child Abuse Negl", "issn": "1873-7757", "volume": null, "issue": null, "pages": "104897", "issn-l": null}, "abstract": "The COVID-19 pandemic could increase violence against children at home. However, collecting empirical data on violence is challenging due to ethical, safety, and data quality concerns.\n\nThis study estimated the anticipated effect of COVID-19 on violent discipline at home using multivariable predictive regression models.\n\nChildren aged 1-14 years and household members from the Multiple Indicator Cluster Surveys (MICS) conducted in Nigeria, Mongolia, and Suriname before the COVID-19 pandemic were included.\n\nA conceptual model of how the COVID-19 pandemic could affect risk factors for violent discipline was developed. Country specific multivariable linear models were used to estimate the association between selected variables from MICS and a violent discipline score which captured the average combination of violent disciplinary methods used in the home. A review of the literature informed the development of quantitative assumptions about how COVID-19 would impact the selected variables under a \"high restrictions\" pandemic scenario, approximating conditions expected during a period of intense response measures, and a \"lower restrictions\" scenario with easing of COVID-19 restrictions but with sustained economic impacts. These assumptions were used to estimate changes in violent discipline scores.\n\nUnder a \"high restrictions\" scenario there would be a 35%-46% increase in violent discipline scores in Nigeria, Mongolia and Suriname, and under a \"lower restrictions\" scenario there would be between a 4%-6% increase in violent discipline scores in these countries.\n\nPolicy makers need to plan for increases in violent discipline during successive waves of lockdowns.", "doi": "10.1016/j.chiabu.2020.104897", "pmid": "33451678", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0145-2134(20)30552-4"}], "notes": [], "created": "2021-01-18T14:37:30.758Z", "modified": "2021-02-26T08:47:00.147Z"}, {"entity": "publication", "iuid": "8da68cb7dd1e494f9d694277f8730a4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8da68cb7dd1e494f9d694277f8730a4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8da68cb7dd1e494f9d694277f8730a4c"}}, "title": "Implications and Limitations of Social Distancing Strategies (SDS) to Mitigate the Impact of the COVID-19 Pandemic.", "authors": [{"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}, {"family": "Burkle", "given": "Frederick M", "initials": "FM"}, {"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}], "type": "journal article", "published": "2020-12-22", "journal": {"title": "Disaster Med Public Health Prep", "issn": "1938-744X", "volume": null, "issue": null, "pages": "1-2", "issn-l": "1935-7893"}, "abstract": null, "doi": "10.1017/dmp.2020.500", "pmid": "33769241", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1935789320005005"}], "notes": [], "created": "2021-03-29T09:26:41.822Z", "modified": "2021-03-29T09:26:41.833Z"}, {"entity": "publication", "iuid": "7029db400dfd4e1592553190873fbe5b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7029db400dfd4e1592553190873fbe5b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7029db400dfd4e1592553190873fbe5b"}}, "title": "Development and external validation of a logistic regression derived formula based on repeated routine hematological measurements predicting survival of hospitalized Covid-19 patients", "authors": [{"family": "Heber", "given": "Stefan", "initials": "S"}, {"family": "Pereyra", "given": "David", "initials": "D"}, {"family": "Schrottmaier", "given": "Waltraud C", "initials": "WC"}, {"family": "Kammerer", "given": "Kerstin", "initials": "K"}, {"family": "Santol", "given": "Jonas", "initials": "J"}, {"family": "Pawelka", "given": "Erich", "initials": "E"}, {"family": "Hana", "given": "Markus", "initials": "M"}, {"family": "Scholz", "given": "Alexander", "initials": "A"}, {"family": "Liu", "given": "Markus", "initials": "M"}, {"family": "Hell", "given": "Agnes", "initials": "A"}, {"family": "Heiplik", "given": "Klara", "initials": "K"}, {"family": "Lickefett", "given": "Benno", "initials": "B"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Traugott", "given": "Marianna T", "initials": "MT"}, {"family": "Neub\u00f6ck", "given": "Matthias", "initials": "M"}, {"family": "Sch\u00f6rgenhofer", "given": "Christian", "initials": "C"}, {"family": "Seitz", "given": "Tamara", "initials": "T"}, {"family": "Firbas", "given": "Christa", "initials": "C"}, {"family": "Karolyi", "given": "Mario", "initials": "M"}, {"family": "Weiss", "given": "G\u00fcnter", "initials": "G"}, {"family": "Jilma", "given": "Bernd", "initials": "B"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Bellmann-Weiler", "given": "Rosa", "initials": "R"}, {"family": "Salzer", "given": "Helmut J F", "initials": "HJF"}, {"family": "Fischer", "given": "Michael J M", "initials": "MJM"}, {"family": "Zoufaly", "given": "Alexander", "initials": "A"}, {"family": "Assinger", "given": "Alice", "initials": "A"}], "type": "posted-content", "published": "2020-12-22", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.20.20248563", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-04T08:54:38.303Z", "modified": "2021-02-26T08:46:13.223Z"}, {"entity": "publication", "iuid": "d22a5c0867e647ceb971ab628b8454eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d22a5c0867e647ceb971ab628b8454eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d22a5c0867e647ceb971ab628b8454eb"}}, "title": "COVID-19 and the Swedish enigma.", "authors": [{"family": "Claeson", "given": "Mariam", "initials": "M"}, {"family": "Hanson", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2020-12-22", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": null, "issue": null, "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)32750-1", "pmid": "33357494", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)32750-1"}, {"db": "pmc", "key": "PMC7755568"}], "notes": [], "created": "2021-01-08T08:19:51.738Z", "modified": "2021-01-10T17:30:11.876Z"}, {"entity": "publication", "iuid": "e5fe6d45987442a8ac2cf0c4068949e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e5fe6d45987442a8ac2cf0c4068949e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e5fe6d45987442a8ac2cf0c4068949e7"}}, "title": "Impact of simulation-based teamwork training on COVID-19 distress in healthcare professionals.", "authors": [{"family": "Beneria", "given": "Anna", "initials": "A"}, {"family": "Arnedo", "given": "Mireia", "initials": "M"}, {"family": "Contreras", "given": "Sofia", "initials": "S"}, {"family": "P\u00e9rez-Carrasco", "given": "Marco", "initials": "M"}, {"family": "Garcia-Ruiz", "given": "Itziar", "initials": "I"}, {"family": "Rodr\u00edguez-Carballeira", "given": "M\u00f3nica", "initials": "M"}, {"family": "Radu\u00e0", "given": "Joaquim", "initials": "J"}, {"family": "Rius", "given": "Jordi Ba\u00f1eras", "initials": "JB"}], "type": "journal article", "published": "2020-12-21", "journal": {"title": "BMC Med Educ", "issn": "1472-6920", "volume": "20", "issue": "1", "pages": "515", "issn-l": null}, "abstract": "Non-technical skills such as leadership, communication, or situation awareness should lead to effective teamwork in a crisis. This study aimed to analyse the role of these skills in the emotional response of health professionals to the COVID-19 pandemic.\n\nBefore the COVID-19 outbreak, 48 doctors and 48 nurses participated in a simulation-based teamwork training program based on teaching non-technical skills through simulation. In May 2020, this group of professionals from a COVID-19 referral hospital was invited to participate in a survey exploring stress, anxiety, and depression, using the PSS-14 (Perceived Stress Scale) and the HADS (Hospital Anxiety and Depression Scale) measures. A control group that did not receive the training was included. We conducted a logistic regression to assess whether having attended a simulation-based teamwork training program modified the probability of presenting psychological distress (PSS-14 > 18 or HADS> 12).\n\nA total of 141 healthcare professionals were included, 77 in the intervention group and 64 in the control group. Based on the PSS-14, 70.1% of the intervention group and 75% of the control group (p = 0.342) had symptoms of stress. Having contact with COVID-19 patients [OR 4.16(1.64-10.52)]; having minors in charge [OR 2.75 (1.15-6.53)]; working as a doctor [0.39(0.16-0.95)], and being a woman [OR 2.94(1.09-7.91)] were related with PSS14 symptoms. Based on the HADS, 54.6% of the intervention group and 42.2% of the control group (p = 0.346) had symptoms of anxiety or depression. Having contact with COVID-19 patients [OR 2.17(1.05-4.48)] and having minors in charge [OR 2.14(1.06-4.32)] were related to HADS symptoms. Healthcare professionals who attended COVID-19 patients showed higher levels of anxiety and depression [OR 2.56(1.03-6.36) (p = 0.043)].\n\nHealthcare professionals trained in non-technical skills through simulation tended towards higher levels of anxiety and depression and fewer levels of stress, during the COVID-19 pandemic.", "doi": "10.1186/s12909-020-02427-4", "pmid": "33349248", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12909-020-02427-4"}, {"db": "pmc", "key": "PMC7751744"}, {"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-08T08:24:47.491Z", "modified": "2021-02-26T08:47:00.263Z"}, {"entity": "publication", "iuid": "d9ea5ba12df64dcf9f67088c9302d0ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d9ea5ba12df64dcf9f67088c9302d0ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d9ea5ba12df64dcf9f67088c9302d0ee"}}, "title": "Covid-19 intensive care admissions and mortality among swedish patients with cancer.", "authors": [{"family": "Larfors", "given": "Gunnar", "initials": "G"}, {"family": "Pahnke", "given": "Simon", "initials": "S"}, {"family": "State", "given": "Maria", "initials": "M"}, {"family": "Fredriksson", "given": "Katarina", "initials": "K"}, {"family": "Pettersson", "given": "David", "initials": "D"}], "type": "letter", "published": "2020-12-21", "journal": {"title": "Acta Oncol", "issn": "1651-226X", "volume": null, "issue": null, "pages": "1-3", "issn-l": null}, "abstract": null, "doi": "10.1080/0284186X.2020.1854481", "pmid": "33345664", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-07T13:30:27.979Z", "modified": "2021-02-26T08:45:48.781Z"}, {"entity": "publication", "iuid": "be488f3e4f824c5a83f9ad103c1b7a5d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be488f3e4f824c5a83f9ad103c1b7a5d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be488f3e4f824c5a83f9ad103c1b7a5d"}}, "title": "Mental health among pregnant women during the pandemic in Sweden\u2013 a mixed methods approach using data from the Mom2B mobile application for research", "authors": [{"family": "Fransson", "given": "Emma", "initials": "E", "orcid": "0000-0001-9010-8522", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c3926adfe6e74e91b084e1e5531af80e.json"}}, {"family": "Karalexi", "given": "Maria", "initials": "M"}, {"family": "Kimmel", "given": "Mary", "initials": "M", "orcid": "0000-0002-6270-5394", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/55a598795f8f4202a6006ba71081d0d0.json"}}, {"family": "Br\u00e4nn", "given": "Emma", "initials": "E", "orcid": "0000-0001-9664-7973", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3add26b456fd4ce0ad3e649aa7aa4dff.json"}}, {"family": "Kollia", "given": "Natasa", "initials": "N", "orcid": "0000-0001-7868-3524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6bbd460a1869481b9dcbf80263ef27e5.json"}}, {"family": "van Zoest", "given": "Vera", "initials": "V", "orcid": "0000-0002-3017-0874", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/72aee535dc8c45478a4cf678e01d2421.json"}}, {"family": "Nordling", "given": "Eira", "initials": "E"}, {"family": "Papadopoulos", "given": "Fotios C", "initials": "FC", "orcid": "0000-0002-8692-3652", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4a12a16c269b479f81b6f8306185cada.json"}}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A", "orcid": "0000-0002-4935-7532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76c46ccb0ade4acaa7b53f3fd4240683.json"}}], "type": "posted-content", "published": "2020-12-20", "journal": {"title": "", "issn": null, "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1101/2020.12.18.20248466", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-10T04:11:26.328Z", "modified": "2021-06-14T06:39:03.115Z"}, {"entity": "publication", "iuid": "8cf9f12e77c94c808fc63cfc8aadd3b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8cf9f12e77c94c808fc63cfc8aadd3b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8cf9f12e77c94c808fc63cfc8aadd3b4"}}, "title": "Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale", "authors": [{"family": "Paramasivam", "given": "Prasath", "initials": "P"}, {"family": "Franke", "given": "Christian", "initials": "C"}, {"family": "St\u00f6ter", "given": "Martin", "initials": "M"}, {"family": "H\u00f6ijer", "given": "Andreas", "initials": "A"}, {"family": "Bartesaghi", "given": "Stefano", "initials": "S"}, {"family": "Sabirsh", "given": "Alan", "initials": "A"}, {"family": "Lindfors", "given": "Lennart", "initials": "L"}, {"family": "Yanez Arteta", "given": "Marianna", "initials": "M"}, {"family": "Dahl\u00e9n", "given": "Anders", "initials": "A"}, {"family": "Bak", "given": "Annette", "initials": "A"}, {"family": "Andersson", "given": "Shalini", "initials": "S"}, {"family": "Kalaidzidis", "given": "Yannis", "initials": "Y"}, {"family": "Bickle", "given": "Marc", "initials": "M"}, {"family": "Zerial", "given": "Marino", "initials": "M"}], "type": "posted-content", "published": "2020-12-20", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.18.423541", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-15T15:56:01.936Z", "modified": "2021-02-26T08:45:48.453Z"}, {"entity": "publication", "iuid": "7b1c5fe3808e43868029cd853560c02a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b1c5fe3808e43868029cd853560c02a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b1c5fe3808e43868029cd853560c02a"}}, "title": "Considerations for scuba and breath-hold divers during the COVID-19 pandemic: A call for awareness.", "authors": [{"family": "Elia", "given": "Antonis", "initials": "A"}, {"family": "Gennser", "given": "Mikael", "initials": "M"}], "type": "journal article", "published": "2020-12-20", "journal": {"title": "Diving Hyperb Med", "issn": "1833-3516", "volume": "50", "issue": "4", "pages": "413-416", "issn-l": null}, "abstract": "In late 2019, a highly pathogenic novel coronavirus (CoV), severe acute respiratory syndrome (SARS)-CoV-2 emerged from Wuhan, China and led to a global pandemic. SARS-CoV-2 has a predilection for the pulmonary system and can result in serious pneumonia necessitating hospitalisation. Computed tomography (CT) chest scans of patients with severe symptoms, show signs of multifocal bilateral ground or ground-glass opacities (GGO) associated with consolidation areas with patchy distribution. However, it is less well known that both asymptomatic and mild symptomatic patients may exhibit similar lung changes. Presumably, the various pathological changes in the lungs may increase the risk of adverse events during diving (e.g., lung barotrauma, pulmonary oedema, etc.), thus these lung manifestations need to be considered prior to allowing resumption of diving. Presently, it is not known how the structural changes in the lungs develop and to what extent they resolve, in particular in asymptomatic carriers and patients with mild disease. However, current evidence indicates that a month of recovery may be too short an interval to guarantee complete pulmonary restitution even after COVID-19 infections not demanding hospital care.", "doi": "10.28920/dhm50.4.413-416", "pmid": "33325024", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-21T10:00:27.634Z", "modified": "2021-01-10T18:14:36.428Z"}, {"entity": "publication", "iuid": "5896670bf8704d568137c3fb607add22", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5896670bf8704d568137c3fb607add22.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5896670bf8704d568137c3fb607add22"}}, "title": "Effects on Gambling Activity From Coronavirus Disease 2019-An Analysis of Revenue-Based Taxation of Online- and Land-Based Gambling Operators During the Pandemic.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-12-17", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "11", "issue": null, "pages": "611939", "issn-l": "1664-0640"}, "abstract": "Background: Concerns have been raised about increased gambling problems during the coronavirus disease (COVID-19) crisis, particularly in settings with high online gambling and risks of migration from land-based to riskier online-based gambling types. However, few non-self-reported data sources are hitherto available. The present study aimed to assess changes in the online- and land-based gambling markets in Sweden during the first months affected by the societal impact of COVID-19. Methods: Data were derived from national authority data describing monthly taxations of all licensed Swedish gambling operators, whose monthly tax payments are directly based on gambling revenue. Subdivisions of the gambling market were followed monthly from before COVID-19 onset in Sweden (mainly February 2020) through June 2020, when the sports market was restarted after COVID-19 lockdown. Results: Overall revenue-based taxations in the licensed gambling decreased markedly from February to March, but stabilized onto an overall modest decrease through June. Commercial online casino/betting, despite some decrease in March, was maintained on a relatively stable level through June. However, within this category, horse betting increased steeply during the pandemic but returned to prepandemic levels later during the period. The state-owned operator in betting/online casino decreased markedly throughout the pandemic. The remaining commercial operators, mainly in online casino and online betting, demonstrated no change during the pandemic and ended on a June level 14% above the February level. Throughout the pandemic, the smaller restaurant casinos decreased markedly, while major state-owned casinos also closed entirely. State-owned lotteries and electronic gambling machines decreased markedly but were rapidly normalized to prepandemic levels. Conclusions: Commercial online gambling operators' revenues remained stable throughout the pandemic, despite the dramatic lockdown in sports. Thus, chance-based online games may have remained a strong actor in the gambling market despite the COVID-19 crisis, in line with previous self-report data. A sudden increase in horse betting during the sports lockdown and its decrease when sports reopened confirm the picture of possible COVID-19-related migration between gambling types, indicating a volatility with potential impact on gambling-related public health.", "doi": "10.3389/fpsyt.2020.611939", "pmid": "33391059", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7773659"}], "notes": [], "created": "2021-01-05T15:18:01.702Z", "modified": "2021-02-26T08:46:59.964Z"}, {"entity": "publication", "iuid": "02b49bae4e8c42dcaecb844185a7ae94", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02b49bae4e8c42dcaecb844185a7ae94.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02b49bae4e8c42dcaecb844185a7ae94"}}, "title": "Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy.", "authors": [{"family": "Wacker", "given": "Anna", "initials": "A"}, {"family": "Weigand", "given": "Julia E", "initials": "JE", "orcid": "0000-0003-4247-1348", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5229ec08ce9242c19049804ff8a77085.json"}}, {"family": "Akabayov", "given": "Sabine R", "initials": "SR"}, {"family": "Altincekic", "given": "Nadide", "initials": "N"}, {"family": "Bains", "given": "Jasleen Kaur", "initials": "JK"}, {"family": "Banijamali", "given": "Elnaz", "initials": "E"}, {"family": "Binas", "given": "Oliver", "initials": "O"}, {"family": "Castillo-Martinez", "given": "Jesus", "initials": "J"}, {"family": "Cetiner", "given": "Erhan", "initials": "E"}, {"family": "Ceylan", "given": "Bet\u00fcl", "initials": "B"}, {"family": "Chiu", "given": "Liang-Yuan", "initials": "LY"}, {"family": "Davila-Calderon", "given": "Jesse", "initials": "J"}, {"family": "Dhamotharan", "given": "Karthikeyan", "initials": "K"}, {"family": "Duchardt-Ferner", "given": "Elke", "initials": "E"}, {"family": "Ferner", "given": "Jan", "initials": "J"}, {"family": "Frydman", "given": "Lucio", "initials": "L"}, {"family": "F\u00fcrtig", "given": "Boris", "initials": "B", "orcid": "0000-0001-6443-7656", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5e0849167334290a5bd6691644783bf.json"}}, {"family": "Gallego", "given": "Jos\u00e9", "initials": "J", "orcid": "0000-0002-0627-6927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b188371610a46858542181b11863966.json"}}, {"family": "Gr\u00fcn", "given": "J Tassilo", "initials": "JT"}, {"family": "Hacker", "given": "Carolin", "initials": "C"}, {"family": "Haddad", "given": "Christina", "initials": "C"}, {"family": "H\u00e4hnke", "given": "Martin", "initials": "M"}, {"family": "Hengesbach", "given": "Martin", "initials": "M", "orcid": "0000-0001-9414-1602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fa75083441294b4f8fe68b1a42fee601.json"}}, {"family": "Hiller", "given": "Fabian", "initials": "F"}, {"family": "Hohmann", "given": "Katharina F", "initials": "KF"}, {"family": "Hymon", "given": "Daniel", "initials": "D"}, {"family": "de Jesus", "given": "Vanessa", "initials": "V"}, {"family": "Jonker", "given": "Henry", "initials": "H"}, {"family": "Keller", "given": "Heiko", "initials": "H"}, {"family": "Knezic", "given": "Bozana", "initials": "B"}, {"family": "Landgraf", "given": "Tom", "initials": "T"}, {"family": "L\u00f6hr", "given": "Frank", "initials": "F"}, {"family": "Luo", "given": "Le", "initials": "L"}, {"family": "Mertinkus", "given": "Klara R", "initials": "KR"}, {"family": "Muhs", "given": "Christina", "initials": "C"}, {"family": "Novakovic", "given": "Mihajlo", "initials": "M"}, {"family": "Oxenfarth", "given": "Andreas", "initials": "A"}, {"family": "Palomino-Sch\u00e4tzlein", "given": "Martina", "initials": "M"}, {"family": "Petzold", "given": "Katja", "initials": "K"}, {"family": "Peter", "given": "Stephen A", "initials": "SA"}, {"family": "Pyper", "given": "Dennis J", "initials": "DJ"}, {"family": "Qureshi", "given": "Nusrat S", "initials": "NS"}, {"family": "Riad", "given": "Magdalena", "initials": "M"}, {"family": "Richter", "given": "Christian", "initials": "C"}, {"family": "Saxena", "given": "Krishna", "initials": "K"}, {"family": "Schamber", "given": "Tatjana", "initials": "T"}, {"family": "Scherf", "given": "Tali", "initials": "T"}, {"family": "Schlagnitweit", "given": "Judith", "initials": "J"}, {"family": "Schlundt", "given": "Andreas", "initials": "A", "orcid": "0000-0003-2254-7560", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/662b48aa496e4109aab02871f6b1d43d.json"}}, {"family": "Schnieders", "given": "Robbin", "initials": "R"}, {"family": "Schwalbe", "given": "Harald", "initials": "H", "orcid": "0000-0001-5693-7909", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32641f04b8504ac493d46947e87e4f59.json"}}, {"family": "Simba-Lahuasi", "given": "Alvaro", "initials": "A"}, {"family": "Sreeramulu", "given": "Sridhar", "initials": "S"}, {"family": "Stirnal", "given": "Elke", "initials": "E"}, {"family": "Sudakov", "given": "Alexey", "initials": "A"}, {"family": "Tants", "given": "Jan-Niklas", "initials": "JN"}, {"family": "Tolbert", "given": "Blanton S", "initials": "BS"}, {"family": "V\u00f6gele", "given": "Jennifer", "initials": "J"}, {"family": "Wei\u00df", "given": "Lena", "initials": "L"}, {"family": "Wirmer-Bartoschek", "given": "Julia", "initials": "J"}, {"family": "Wirtz Martin", "given": "Maria A", "initials": "MA"}, {"family": "W\u00f6hnert", "given": "Jens", "initials": "J", "orcid": "0000-0001-7193-401X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/611eebfc08f54e20b4dc9b881da010b8.json"}}, {"family": "Zetzsche", "given": "Heidi", "initials": "H"}], "type": "journal article", "published": "2020-12-16", "journal": {"title": "Nucleic Acids Res", "issn": "1362-4962", "volume": "48", "issue": "22", "pages": "12415-12435", "issn-l": "0305-1048"}, "abstract": "The current pandemic situation caused by the Betacoronavirus SARS-CoV-2 (SCoV2) highlights the need for coordinated research to combat COVID-19. A particularly important aspect is the development of medication. In addition to viral proteins, structured RNA elements represent a potent alternative as drug targets. The search for drugs that target RNA requires their high-resolution structural characterization. Using nuclear magnetic resonance (NMR) spectroscopy, a worldwide consortium of NMR researchers aims to characterize potential RNA drug targets of SCoV2. Here, we report the characterization of 15 conserved RNA elements located at the 5' end, the ribosomal frameshift segment and the 3'-untranslated region (3'-UTR) of the SCoV2 genome, their large-scale production and NMR-based secondary structure determination. The NMR data are corroborated with secondary structure probing by DMS footprinting experiments. The close agreement of NMR secondary structure determination of isolated RNA elements with DMS footprinting and NMR performed on larger RNA regions shows that the secondary structure elements fold independently. The NMR data reported here provide the basis for NMR investigations of RNA function, RNA interactions with viral and host proteins and screening campaigns to identify potential RNA binders for pharmaceutical intervention.", "doi": "10.1093/nar/gkaa1013", "pmid": "33167030", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7736788"}, {"db": "pii", "key": "5961789"}], "notes": [], "created": "2020-11-27T10:04:35.267Z", "modified": "2023-06-19T15:30:37.089Z"}, {"entity": "publication", "iuid": "343607ba24654e4c81bcf4e66035a688", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/343607ba24654e4c81bcf4e66035a688.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/343607ba24654e4c81bcf4e66035a688"}}, "title": "Large differences in community COVID-19 testing across geographic areas in a Swedish region with 385,000 inhabitants", "authors": [{"family": "Kennedy", "given": "Beatrice", "initials": "B"}, {"family": "Martinell", "given": "Mats", "initials": "M"}, {"family": "Hammar", "given": "Ulf", "initials": "U"}, {"family": "van Zoest", "given": "Vera", "initials": "V"}, {"family": "Kristiansson", "given": "Robert S", "initials": "RS"}, {"family": "Fitipaldi", "given": "Hugo", "initials": "H"}, {"family": "Tsereteli", "given": "Neli", "initials": "N"}, {"family": "Varotsis", "given": "Georgios", "initials": "G"}, {"family": "Dekkers", "given": "Koen", "initials": "K"}, {"family": "Bjork", "given": "Jonas", "initials": "J"}, {"family": "Fall", "given": "Tove", "initials": "T"}], "type": "posted-content", "published": "2020-12-16", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.15.20248247", "pmid": null, "labels": {"Type: Preprint": null, "Funder: Vinnova": null, "Category: Public Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-12-18T07:46:23.709Z", "modified": "2021-02-26T08:46:59.897Z"}, {"entity": "publication", "iuid": "2c67476bc4a941ec8ef786c921115f6a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c67476bc4a941ec8ef786c921115f6a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c67476bc4a941ec8ef786c921115f6a"}}, "title": "Effects of Dapagliflozin on Prevention of Major Clinical Events and Recovery in Patients with Respiratory Failure due to COVID-19: The Design and Rationale for the DARE-19 study.", "authors": [{"family": "Kosiborod", "given": "Mikhail", "initials": "M"}, {"family": "Berwanger", "given": "Otavio", "initials": "O"}, {"family": "Koch", "given": "Gary G", "initials": "GG"}, {"family": "Martinez", "given": "Felipe", "initials": "F"}, {"family": "Mukhtar", "given": "Omar", "initials": "O"}, {"family": "Verma", "given": "Subodh", "initials": "S"}, {"family": "Chopra", "given": "Vijay", "initials": "V"}, {"family": "Javaheri", "given": "Ali", "initials": "A"}, {"family": "Ambery", "given": "Philip", "initials": "P"}, {"family": "Gasparyan", "given": "Samvel B", "initials": "SB"}, {"family": "Buenconsejo", "given": "Joan", "initials": "J"}, {"family": "Sj\u00f6str\u00f6m", "given": "C David", "initials": "CD"}, {"family": "Langkilde", "given": "Anna Maria", "initials": "AM"}, {"family": "Oscarsson", "given": "Jan", "initials": "J"}, {"family": "Esterline", "given": "Russell", "initials": "R"}], "type": "journal article", "published": "2020-12-15", "journal": {"title": "Diabetes Obes Metab", "issn": "1463-1326", "issn-l": null, "volume": "23", "issue": "4", "pages": "886-896"}, "abstract": "Coronavirus disease 2019 (COVID-19) is caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It can lead to multiorgan failure, including respiratory and cardiovascular decompensation, and kidney injury, with significant associated morbidity and mortality, particularly in patients with underlying metabolic, cardiovascular, respiratory, or kidney disease. Dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, has shown significant cardio- and renoprotective benefits in patients with type 2 diabetes (with and without atherosclerotic cardiovascular disease), heart failure, and chronic kidney disease, and may provide similar organ protection in high-risk patients with COVID-19.\r\n\r\nDARE-19 (NCT04350593) is an investigator-initiated, collaborative, international, multicenter, randomized, double-blind, placebo-controlled study testing the dual hypotheses that dapagliflozin can reduce the incidence of cardiovascular, kidney and/or respiratory complications or all-cause mortality, or improve clinical recovery, in adult patients hospitalized with COVID-19 but not critically ill on admission. Eligible patients will have \u22651 cardiometabolic risk factor for COVID-19 complications. Patients will be randomized 1:1 to dapagliflozin 10 mg or placebo. Primary efficacy endpoints are time to development of new or worsened organ dysfunction during index hospitalization, or all-cause mortality, and the hierarchical composite endpoint of change in clinical status through Day 30 of treatment. Safety of dapagliflozin in individuals with COVID-19 will be assessed.\r\n\r\nDARE-19 will evaluate whether dapagliflozin can prevent COVID-19-related complications and all-cause mortality, or improve clinical recovery, and assess dapagliflozin's safety profile in this patient population. Currently, DARE-19 is the first large randomized controlled trial investigating use of SGLT2 inhibitors in patients with COVID-19. This article is protected by copyright. All rights reserved.", "doi": "10.1111/dom.14296", "pmid": "33319454", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-21T10:06:26.130Z", "modified": "2021-04-10T09:47:17.457Z"}, {"entity": "publication", "iuid": "a51a373837da48a78fb9bb0ed8a526c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a51a373837da48a78fb9bb0ed8a526c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a51a373837da48a78fb9bb0ed8a526c9"}}, "title": "COVID-19 Highlights the Need for Inclusive Responses to Public Health Emergencies in Africa.", "authors": [{"family": "Adebisi", "given": "Yusuff Adebayo", "initials": "YA"}, {"family": "Ekpenyong", "given": "Aniekan", "initials": "A"}, {"family": "Ntacyabukura", "given": "Blaise", "initials": "B"}, {"family": "Lowe", "given": "Mat", "initials": "M"}, {"family": "Jimoh", "given": "Nafisat Dasola", "initials": "ND"}, {"family": "Abdulkareem", "given": "Toyyib Oladimeji", "initials": "TO"}, {"family": "Lucero-Prisno", "given": "Don Eliseo", "initials": "DE"}], "type": "journal article", "published": "2020-12-15", "journal": {"title": "Am J Trop Med Hyg", "issn": "1476-1645", "volume": null, "issue": null, "issn-l": "0002-9637"}, "abstract": "COVID-19 is a global public health emergency affecting many countries around the world. Although African governments and other stakeholders are making efforts to contain the pandemic, the outbreak continues to impact human rights and exacerbates inequalities and disparities that are already in existence. The concept of inclusive health focuses on good health and well-being for everyone, and this entails health services that are equitable, affordable, and efficacious. Creating equitable access to mainstream health and healthcare services and ensuring inclusive health responses remain a means of addressing health inequities and disparities. In this article, we argue on the need for inclusive responses to public health emergencies in Africa using COVID-19 as a case example. Africa's response to public health emergencies needs to recognize that for every marginalized/vulnerable group, it is important to strategize to address their particular needs in such a way to surmount any barrier to the right to health. For Africa's public health response to be more inclusive, we therefore need to be more strategic and proactive in reaching out to specific groups and to identify and address their needs. Strengthening the healthcare systems of African countries through increased political will, increased funding to health care, collaboration and cooperation among stakeholders, and effective leadership remains essential in ensuring inclusive responses to health emergencies.", "doi": "10.4269/ajtmh.20-1485", "pmid": "33331263", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2020-12-21T08:57:29.223Z", "modified": "2021-02-26T08:47:00.142Z"}, {"entity": "publication", "iuid": "a8cae6475f344161a6e12d8f1616c9c2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8cae6475f344161a6e12d8f1616c9c2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8cae6475f344161a6e12d8f1616c9c2"}}, "title": "The coronavirus pandemic: a pitfall or a fast-track for validating cell therapy products?", "authors": [{"family": "Khoury", "given": "Maroun", "initials": "M"}, {"family": "Ikonomou", "given": "Laertis", "initials": "L"}, {"family": "Dominici", "given": "Massimo", "initials": "M"}, {"family": "Le Blanc", "given": "Katarina", "initials": "K"}, {"family": "Levine", "given": "Bruce L", "initials": "BL"}, {"family": "Weiss", "given": "Dan J", "initials": "DJ"}], "type": "journal article", "published": "2020-12-14", "journal": {"title": "Stem Cells Dev", "issn": "1557-8534", "volume": null, "issue": null, "issn-l": null}, "abstract": "The global COVID-19 pandemic has prompted urgent need for potential therapies for severe respiratory consequences resulting from coronavirus infection. New therapeutic agents that will attenuate ongoing inflammation and, at the same time, promote regeneration of injured lung epithelial cells are urgently needed. Cell-based therapies, primarily involving mesenchymal stromal cells (MSCs) and their derivatives are currently being investigated worldwide for SARS-CoV-2-induced lung diseases. A significant number of academic centers and companies globally have already initiated such trials. At a time of unprecedented need, it is it is also foreseen that distressed families, and caregivers to seek all available options including access to cell-based and other investigational products, even prior to its regulatory approval. This should not be an excuse for opportunists to sell or advertise unproven therapies of any kind. \"Compassionate use\" should be conducted in the context of a clinical investigation framed by strict ethical and regulatory permissions, with the goal of obtaining mechanistic information wherever possible.", "doi": "10.1089/scd.2020.0122", "pmid": "33307968", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-21T10:19:40.918Z", "modified": "2020-12-21T10:19:40.956Z"}, {"entity": "publication", "iuid": "79337d3b64b34c6aaa6f4da531eb17d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/79337d3b64b34c6aaa6f4da531eb17d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/79337d3b64b34c6aaa6f4da531eb17d9"}}, "title": "The Impact of the COVID-19 Pandemic on People with Diabetes and Diabetes Services: A pan-European Survey of Diabetes Specialist Nurses undertaken by the Foundation of European Nurses in Diabetes survey consortium.", "authors": [{"family": "Forde", "given": "Rita", "initials": "R"}, {"family": "Arente", "given": "Liga", "initials": "L"}, {"family": "Ausili", "given": "Davide", "initials": "D"}, {"family": "De Backer", "given": "Kristin", "initials": "K"}, {"family": "Due-Christensen", "given": "Mette", "initials": "M"}, {"family": "Epps", "given": "Amanda", "initials": "A"}, {"family": "Fitzpatrick", "given": "Anne", "initials": "A"}, {"family": "Grixti", "given": "Moira", "initials": "M"}, {"family": "Groen", "given": "Sijda", "initials": "S"}, {"family": "Halkoaho", "given": "Arja", "initials": "A"}, {"family": "Huber", "given": "Claudia", "initials": "C"}, {"family": "Iversen", "given": "Marjolein M", "initials": "MM"}, {"family": "Johansson", "given": "Unn-Britt", "initials": "UB"}, {"family": "Leippert", "given": "Claudia", "initials": "C"}, {"family": "Ozcan", "given": "Seyda", "initials": "S"}, {"family": "Parker", "given": "Julie", "initials": "J"}, {"family": "Paiva", "given": "Ana Christina", "initials": "AC"}, {"family": "Sanpetreanu", "given": "Adina", "initials": "A"}, {"family": "Savet", "given": "Marie-Alice", "initials": "MA"}, {"family": "Rosana", "given": "Svetic-Cisic", "initials": "SC"}, {"family": "Szewczyk", "given": "Alicja", "initials": "A"}, {"family": "Valverde", "given": "Maite", "initials": "M"}, {"family": "Vlachou", "given": "Eugenia", "initials": "E"}, {"family": "Forbes", "given": "Angus", "initials": "A"}, {"family": "FEND COVID-19 consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2020-12-14", "journal": {"title": "Diabet Med", "issn": "1464-5491", "volume": null, "issue": null, "pages": "e14498", "issn-l": null}, "abstract": "To describe diabetes nurses' perspectives on the impact of the COVID-19 pandemic on people with diabetes and diabetes services across Europe.\n\nAn online survey developed using a rapid Delphi method. The survey was translated into 17 different languages and disseminated electronically in 27 countries via national diabetes nurse networks.\n\nSurvey responses from 1829 diabetes nurses were included in the analysis. The responses indicated that 28% (n=504) and 48% (n=873) of diabetes nurses felt the COVID-19 pandemic had impacted 'a lot' on the physical and psychological risks of people with diabetes, respectively. The following clinical problems were identified as having increased 'a lot': anxiety 82% (n=1486); diabetes distress 65% (n=1189); depression 49% (n= 893); acute hyperglycaemia 39% (n=710); and foot complications 17% (n=323). Forty-seven percent (n=771) of respondents identified that the level of care provided to people with diabetes had declined either extremely or quite severely. Self-management support, diabetes education and psychological support were rated by diabetes nurse respondents as having declined extremely or quite severely during the COVID-19 pandemic by 31% (n=499), 63% (n=1,027) and 34% (n=551), respectively.\n\nThe findings show that diabetes nurses across Europe have seen significant increases in both physical and psychological problems in their patient populations during COVID-19. The data also show that clinical diabetes services have been significantly disrupted. As the COVID-19 situation continues we need to adapt care systems with some urgency to minimise the impact of the pandemic on the diabetes population.", "doi": "10.1111/dme.14498", "pmid": "33314244", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-21T10:17:40.765Z", "modified": "2021-01-08T08:18:44.786Z"}, {"entity": "publication", "iuid": "5c6f4fbc1a2247c395f119b0d31efabc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c6f4fbc1a2247c395f119b0d31efabc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c6f4fbc1a2247c395f119b0d31efabc"}}, "title": "Screening for high amounts of SARS-CoV-2 identifies pre-symptomatic subjects among healthy healthcare workers", "authors": [{"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Elfstr\u00f6m", "given": "K Miriam", "initials": "KM"}, {"family": "Blomqvist", "given": "Jonas", "initials": "J"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M"}, {"family": "Eklund", "given": "Carina", "initials": "C"}, {"family": "Boulund", "given": "Fredrik", "initials": "F"}, {"family": "Lagheden", "given": "Camilla", "initials": "C"}, {"family": "Hamsten", "given": "Marica", "initials": "M"}, {"family": "Nordqvist-Kleppe", "given": "Sara", "initials": "S"}, {"family": "Seifert", "given": "Maike", "initials": "M"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Olofsson", "given": "Jennie", "initials": "J"}, {"family": "Andersson", "given": "Eni", "initials": "E"}, {"family": "Falk", "given": "August Jernbom", "initials": "AJ"}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S"}, {"family": "Hultin", "given": "Emilie", "initials": "E"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Pimenoff", "given": "Ville N", "initials": "VN"}, {"family": "Hassan", "given": "Sadaf", "initials": "S"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Mattsson", "given": "Johan", "initials": "J"}, {"family": "M\u00fchr", "given": "Laila Sara Arroyo", "initials": "LSA"}, {"family": "Lundgren", "given": "Kalle Conneryd", "initials": "KC"}], "type": "posted-content", "published": "2020-12-14", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.13.20248122", "pmid": null, "labels": {"Type: Preprint": null, "Research Area: High-throughput and high-content serology": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}, {"db": "ClinicalTrials.gov", "key": "NCT04411576", "description": null}], "notes": [], "created": "2020-12-18T07:50:57.449Z", "modified": "2023-06-19T14:24:06.940Z"}, {"entity": "publication", "iuid": "0a55e1fb2e0d4307820500d6d439b2c4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a55e1fb2e0d4307820500d6d439b2c4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a55e1fb2e0d4307820500d6d439b2c4"}}, "title": "Rapid Assessment of Price Instability and Paucity of Medicines and Protection for COVID-19 Across Asia: Findings and Public Health Implications for the Future.", "authors": [{"family": "Godman", "given": "Brian", "initials": "B"}, {"family": "Haque", "given": "Mainul", "initials": "M"}, {"family": "Islam", "given": "Salequl", "initials": "S"}, {"family": "Iqbal", "given": "Samiul", "initials": "S"}, {"family": "Urmi", "given": "Umme Laila", "initials": "UL"}, {"family": "Kamal", "given": "Zubair Mahmood", "initials": "ZM"}, {"family": "Shuvo", "given": "Shahriar Ahmed", "initials": "SA"}, {"family": "Rahman", "given": "Aminur", "initials": "A"}, {"family": "Kamal", "given": "Mustafa", "initials": "M"}, {"family": "Haque", "given": "Monami", "initials": "M"}, {"family": "Jahan", "given": "Iffat", "initials": "I"}, {"family": "Islam", "given": "Md Zakirul", "initials": "MZ"}, {"family": "Hossain", "given": "Mohammad Monir", "initials": "MM"}, {"family": "Kumar", "given": "Santosh", "initials": "S"}, {"family": "Charan", "given": "Jaykaran", "initials": "J"}, {"family": "Bhatt", "given": "Rohan", "initials": "R"}, {"family": "Dutta", "given": "Siddhartha", "initials": "S"}, {"family": "Abhayanand", "given": "Jha Pallavi", "initials": "JP"}, {"family": "Sharma", "given": "Yesh", "initials": "Y"}, {"family": "Saleem", "given": "Zikria", "initials": "Z"}, {"family": "Phuong", "given": "Thuy Nguyen Thi", "initials": "TNT"}, {"family": "Kwon", "given": "Hye-Young", "initials": "HY"}, {"family": "Kurdi", "given": "Amanj", "initials": "A"}, {"family": "Wale", "given": "Janney", "initials": "J"}, {"family": "Sefah", "given": "Israel", "initials": "I"}], "type": "journal article", "published": "2020-12-14", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "585832", "issn-l": "2296-2565"}, "abstract": "Background: Countries have introduced a variety of measures to prevent and treat COVID-19 with medicines and personal protective equipment (PPE), with some countries adopting preventative strategies earlier than others. However, there has been considerable controversy surrounding some treatments. This includes hydroxychloroquine where the initial hype and misinformation lead to shortages, price rises and suicides. Price rises and shortages have also been seen for PPE. Such activities can have catastrophic effects on patients where there are high co-payment levels and issues of affordability. Consequently, there is a need to investigate this further. Objective: Assess changes in the availability, utilization and prices of relevant medicines and PPE during the pandemic among a range of Asian countries. Our approach: Narrative literature review combined with interviews among community pharmacists to assess changes in consumption, prices and shortages of medicines and PPE from the beginning of March 2020 until end of May 2020. In addition, suggestions on ways to reduce misinformation. Results: 308 pharmacists took part from five Asian countries. There was an appreciable increase in the utilization of antimicrobials in Pakistan (in over 88% of pharmacies), with lower increases or no change in Bangladesh, India, Malaysia and Vietnam. Encouragingly, there was increased use of vitamins/immune boosters and PPE across the countries, as well as limited price rises for antimicrobials in India, Malaysia and Vietnam, although greater price rises seen for analgesics and vitamin C/immune boosters. Appreciable price increases were also seen for PPE across some countries. Conclusion: Encouraging to see increases in utilization of vitamins/immune boosters and PPE. However, increases in the utilization and prices of antimicrobials is a concern that needs addressing alongside misinformation and any unintended consequences from the pandemic. Community pharmacists can play a key role in providing evidence-based advice, helping to moderate prices, as well as helping address some of the unintended consequences of the pandemic.", "doi": "10.3389/fpubh.2020.585832", "pmid": "33381485", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7767884"}, {"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-07T12:08:28.441Z", "modified": "2021-02-26T08:46:59.826Z"}, {"entity": "publication", "iuid": "31fa7f460b4b485b93fa9345954bb9ea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/31fa7f460b4b485b93fa9345954bb9ea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/31fa7f460b4b485b93fa9345954bb9ea"}}, "title": "Covid-19: Sweden considers tougher restrictions as ICU beds near capacity.", "authors": [{"family": "Paterlini", "given": "Marta", "initials": "M"}], "type": "journal article", "published": "2020-12-14", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "371", "issue": null, "pages": "m4833", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m4833", "pmid": "33318030", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-21T10:16:30.160Z", "modified": "2020-12-21T10:16:30.188Z"}, {"entity": "publication", "iuid": "55331c5e35f74d09a14cbe3534f72131", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/55331c5e35f74d09a14cbe3534f72131.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/55331c5e35f74d09a14cbe3534f72131"}}, "title": "Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features.", "authors": [{"family": "Hassan", "given": "Sk Sarif", "initials": "SS"}, {"family": "Ghosh", "given": "Shinjini", "initials": "S"}, {"family": "Attrish", "given": "Diksha", "initials": "D"}, {"family": "Choudhury", "given": "Pabitra Pal", "initials": "PP"}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA"}, {"family": "Uhal", "given": "Bruce D", "initials": "BD"}, {"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN"}, {"family": "Seyran", "given": "Murat", "initials": "M"}, {"family": "Pizzol", "given": "Damiano", "initials": "D"}, {"family": "Adadi", "given": "Parise", "initials": "P"}, {"family": "Soares", "given": "Antonio", "initials": "A"}, {"family": "El-Aziz", "given": "Tarek Mohamed Abd", "initials": "TMA"}, {"family": "Kandimalla", "given": "Ramesh", "initials": "R"}, {"family": "Tambuwala", "given": "Murtaza M", "initials": "MM"}, {"family": "Azad", "given": "Gajendra Kumar", "initials": "GK"}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Baetas-da-Cruz", "given": "Wagner", "initials": "W"}, {"family": "Takayama", "given": "Kazuo", "initials": "K"}, {"family": "Serrano-Aroca", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "Chauhan", "given": "Gaurav", "initials": "G"}, {"family": "Palu", "given": "Giorgio", "initials": "G"}, {"family": "Brufsky", "given": "Adam M", "initials": "AM"}], "type": "journal article", "published": "2020-12-13", "journal": {"title": "Molecules", "issn": "1420-3049", "volume": "25", "issue": "24", "pages": "5906", "issn-l": null}, "abstract": "Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22-42, aa 79-84, and aa 330-393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species.", "doi": "10.3390/molecules25245906", "pmid": "33322198", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "molecules25245906"}], "notes": [], "created": "2020-12-21T10:03:41.914Z", "modified": "2021-02-26T08:45:48.163Z"}, {"entity": "publication", "iuid": "ba31a9e9933a4ca68a0efcbeb9cad020", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ba31a9e9933a4ca68a0efcbeb9cad020.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ba31a9e9933a4ca68a0efcbeb9cad020"}}, "title": "The role of extracellular DNA in COVID-19: clues from inflamm-aging.", "authors": [{"family": "Storci", "given": "Gianluca", "initials": "G"}, {"family": "Bonifazi", "given": "Francesca", "initials": "F"}, {"family": "Garagnani", "given": "Paolo", "initials": "P"}, {"family": "Olivieri", "given": "Fabiola", "initials": "F"}, {"family": "Bonaf\u00e8", "given": "Massimiliano", "initials": "M"}], "type": "journal article", "published": "2020-12-12", "journal": {"title": "Ageing Res Rev", "issn": "1872-9649", "volume": "66", "issue": null, "pages": "101234", "issn-l": "1568-1637"}, "abstract": "Epidemiological data convey severe prognosis and high mortality rate for COVID-19 in elderly men affected by age-related diseases. These subjects develop local and systemic hyper-inflammation, which are associated with thrombotic complications and multi-organ failure. Therefore, understanding SARS-CoV-2 induced hyper-inflammation in elderly men is a pressing need. Here we focus on the role of extracellular DNA, mainly mitochondrial DNA (mtDNA) and telomeric DNA (telDNA) in the modulation of systemic inflammation in these subjects. In particular, extracellular mtDNA is regarded as a powerful trigger of the inflammatory response. On the contrary, extracellular telDNA pool is estimated to be capable of inhibiting a variety of inflammatory pathways. In turn, we underpin that telDNA reservoir is progressively depleted during aging, and that it is scarcer in men than in women. We propose that an increase in extracellular mtDNA, concomitant with the reduction of the anti-inflammatory telDNA reservoir may explain hyper-inflammation in elderly male affected by COVID-19. This scenario is reminiscent of inflamm-aging, the portmanteau word that depicts how aging and aging related diseases are intimately linked to inflammation.", "doi": "10.1016/j.arr.2020.101234", "pmid": "33321254", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1568-1637(20)30369-X"}], "notes": [], "created": "2020-12-21T10:05:39.471Z", "modified": "2021-01-10T18:17:21.167Z"}, {"entity": "publication", "iuid": "353c836a008149b6b1884eaf9e5c3dcb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/353c836a008149b6b1884eaf9e5c3dcb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/353c836a008149b6b1884eaf9e5c3dcb"}}, "title": "The MERS-CoV receptor gene is among COVID-19 risk factors inherited from Neandertals", "authors": [{"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "Paabo", "given": "Svante", "initials": "S"}], "type": "posted-content", "published": "2020-12-12", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.11.422139", "pmid": null, "labels": {"Type: Preprint": null, "Category: Genomics & transcriptomics": null, "Category: Other": null}, "xrefs": [{"db": "URL", "key": "http://cdna.eva.mpg.de/neandertal/Vindija/VCF/", "description": "Croatian Neandertal genome"}, {"db": "URL", "key": "https://bioinf.eva.mpg.de/jbrowse/", "description": "Croatian Neandertal genome"}, {"db": "URL", "key": "http://ftp.1000genomes.ebi.ac.uk/vol1/ftp/release/20130502/", "description": "Modern human genomes at the 1000 Genomes Project"}, {"db": "URL", "key": "https://www.covid19hg.org/results/", "description": "GWAS summary statistics (round 4 release: A/B2_ALL_eur_leave_23andme)"}], "notes": [], "created": "2021-01-08T08:41:17.454Z", "modified": "2021-02-26T08:46:13.031Z"}, {"entity": "publication", "iuid": "e333d7fb14ef4f8ab958615325a0d36d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e333d7fb14ef4f8ab958615325a0d36d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e333d7fb14ef4f8ab958615325a0d36d"}}, "title": "Home-Based Care for People with Alzheimer's Disease and Related Dementias (ADRD) during COVID-19 Pandemic: From Challenges to Solutions.", "authors": [{"family": "Sm-Rahman", "given": "Atiqur", "initials": "A"}, {"family": "Lo", "given": "Chih Hung", "initials": "CH"}, {"family": "Ramic", "given": "Azra", "initials": "A"}, {"family": "Jahan", "given": "Yasmin", "initials": "Y"}], "type": "journal article", "published": "2020-12-12", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "17", "issue": "24", "pages": "9303", "issn-l": null}, "abstract": "There has been supporting evidence that older adults with underlying health conditions form the majority of the fatal cases in the current novel coronavirus disease (COVID-19) pandemic. While the impact of COVID-19 is affecting the general public, it is clear that these distressful experiences will be magnified in older adults, particularly people living with Alzheimer's disease and related dementia (ADRD), making them the most vulnerable group during this time. People with differing degrees of ADRD are especially susceptible to the virus, not only because of their difficulties in assessing the threat or remembering the safety measures, but also because of the likelihood to be subject to other risk factors, such as lack of proper care and psychological issues. Therefore, in this article, we will discuss the challenges related to home-based care for people with ADRD during a pandemic and propose a formulation of systematic solutions to address these challenges and to alleviate the social and economic impact resulting from the crisis.", "doi": "10.3390/ijerph17249303", "pmid": "33322696", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph17249303"}], "notes": [], "created": "2020-12-21T10:02:09.026Z", "modified": "2021-02-26T08:45:48.802Z"}, {"entity": "publication", "iuid": "e6263b3ecca646cf92defcc715504da1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6263b3ecca646cf92defcc715504da1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6263b3ecca646cf92defcc715504da1"}}, "title": "Will the COVID-19 pandemic lead to a tsunami of suicides? A Swedish nationwide analysis of historical and 2020 data", "authors": [{"family": "R\u00fcck", "given": "Christian", "initials": "C"}, {"family": "Mataix-Cols", "given": "David", "initials": "D"}, {"family": "Malki", "given": "Kinda", "initials": "K"}, {"family": "Adler", "given": "Mats", "initials": "M"}, {"family": "Flygare", "given": "Oskar", "initials": "O"}, {"family": "Runeson", "given": "Bo", "initials": "B"}, {"family": "Sidorchuk", "given": "Anna", "initials": "A"}], "type": "posted-content", "published": "2020-12-11", "journal": {"title": "", "issn": null, "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1101/2020.12.10.20244699", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-09T19:31:08.617Z", "modified": "2021-06-09T19:31:08.617Z"}, {"entity": "publication", "iuid": "ec1877b0d29b4867afe2f155af937d3b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec1877b0d29b4867afe2f155af937d3b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec1877b0d29b4867afe2f155af937d3b"}}, "title": "Virtual and In Vitro Antiviral Screening Revive Therapeutic Drugs for COVID-19", "authors": [{"family": "Bocci", "given": "Giovanni", "initials": "G"}, {"family": "Bradfute", "given": "Steven B", "initials": "SB"}, {"family": "Ye", "given": "Chunyan", "initials": "C"}, {"family": "Garcia", "given": "Matthew J", "initials": "MJ"}, {"family": "Parvathareddy", "given": "Jyothi", "initials": "J"}, {"family": "Reichard", "given": "Walter", "initials": "W"}, {"family": "Surendranathan", "given": "Surekha", "initials": "S"}, {"family": "Bansal", "given": "Shruti", "initials": "S"}, {"family": "Bologa", "given": "Cristian G", "initials": "CG"}, {"family": "Perkins", "given": "Douglas J", "initials": "DJ"}, {"family": "Jonsson", "given": "Colleen B", "initials": "CB"}, {"family": "Sklar", "given": "Larry A", "initials": "LA"}, {"family": "Oprea", "given": "Tudor I", "initials": "TI"}], "type": "journal-article", "published": "2020-12-11", "journal": {"title": "ACS Pharmacol. Transl. Sci.", "issn": "2575-9108", "issn-l": null, "volume": "3", "issue": "6", "pages": "1278-1292"}, "abstract": "The urgent need for a cure for early phase COVID-19 infected patients critically underlines drug repositioning strategies able to efficiently identify new and reliable treatments by merging computational, experimental, and pharmacokinetic expertise. Here we report new potential therapeutics for COVID-19 identified with a combined virtual and experimental screening strategy and selected among already approved drugs. We used hydroxychloroquine (HCQ), one of the most studied drugs in current clinical trials, as a reference template to screen for structural similarity against a library of almost 4000 approved drugs. The top-ranked drugs, based on structural similarity to HCQ, were selected for in vitro antiviral assessment. Among the selected drugs, both zuclopenthixol and nebivolol efficiently block SARS-CoV-2 infection with EC50 values in the low micromolar range, as confirmed by independent experiments. The anti-SARS-CoV-2 potential of ambroxol, amodiaquine, and its active metabolite (N-monodesethyl amodiaquine) is also discussed. In trying to understand the \"hydroxychloroquine\" mechanism of action, both pKa and the HCQ aromatic core may play a role. Further, we show that the amodiaquine metabolite and, to a lesser extent, zuclopenthixol and nebivolol are active in a SARS-CoV-2 titer reduction assay. Given the need for improved efficacy and safety, we propose zuclopenthixol, nebivolol, and amodiaquine as potential candidates for clinical trials against the early phase of the SARS-CoV-2 infection and discuss their potential use as adjuvant to the current (i.e., remdesivir and favipiravir) COVID-19 therapeutics.", "doi": "10.1021/acsptsci.0c00131", "pmid": "33330842", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-01-10T18:12:02.890Z", "modified": "2021-02-26T08:45:25.930Z"}, {"entity": "publication", "iuid": "8f4719a29b274ec78a4692ec6e333afe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f4719a29b274ec78a4692ec6e333afe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f4719a29b274ec78a4692ec6e333afe"}}, "title": "Thermal inactivation of COVID-19 specimens improves RNA quality and quantity.", "authors": [{"family": "Hemati", "given": "Maral", "initials": "M"}, {"family": "Soosanabadi", "given": "Mohsen", "initials": "M"}, {"family": "Ghorashi", "given": "Tahereh", "initials": "T"}, {"family": "Ghaffari", "given": "Hadi", "initials": "H"}, {"family": "Vahedi", "given": "Azadeh", "initials": "A"}, {"family": "Sabbaghian", "given": "Elaheh", "initials": "E"}, {"family": "Rasouli Nejad", "given": "Zahra", "initials": "Z"}, {"family": "Salati", "given": "Amir", "initials": "A"}, {"family": "Danaei", "given": "Navid", "initials": "N"}, {"family": "Kokhaei", "given": "Parviz", "initials": "P"}], "type": "journal article", "published": "2020-12-11", "journal": {"title": "J Cell Physiol", "issn": "1097-4652", "volume": null, "issue": null, "issn-l": null}, "abstract": "The rapid spread of coronavirus disease 2019 (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2, poses a huge demand for immediate diagnosis. Real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) of nasopharyngeal (NP) and oropharyngeal (OP) swabs have been used to confirm the clinical diagnosis. To avoid the risk of viral-exposure of laboratory workers, thermal inactivation is currently recommended but has unknown effects on the accuracy of the rRT-PCR results. Thirty-six NP/OP specimens were collected from COVID-19 patients and subjected to thermal inactivation (60\u00b0C for 30 min) or the RNA extraction processes to activate the form. Here, our data showed that the concentration of extracted-RNA increases upon thermal inactivation compared to the active form (p = .028). Significantly higher levels of RNA copy number were obtained in inactivated compared to the active samples for both N and ORF1ab genes (p = .009, p = .032, respectively). Thermal inactivation elevated concentration and copy number of extracted-RNA, possibly through viral-capsid degradation and/or nucleoprotein denaturation.", "doi": "10.1002/jcp.30206", "pmid": "33305832", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "NA", "key": "All data is included in the paper", "description": null}], "notes": [], "created": "2020-12-13T07:09:52.986Z", "modified": "2021-11-18T10:50:34.005Z"}, {"entity": "publication", "iuid": "436a8679ea6f4aabb1a29e5b881218c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/436a8679ea6f4aabb1a29e5b881218c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/436a8679ea6f4aabb1a29e5b881218c5"}}, "title": "SARS-CoV-2 genome diversity at the binding sites of oligonucleotides used for COVID-19 diagnosis", "authors": [{"family": "Valieris", "given": "Renan", "initials": "R"}, {"family": "Kowaslki", "given": "Michal", "initials": "M"}, {"family": "Frolova", "given": "Alina", "initials": "A"}, {"family": "Wydmanski", "given": "Witold", "initials": "W"}, {"family": "Foox", "given": "Johnathan", "initials": "J"}, {"family": "Torrezan", "given": "Giovana", "initials": "G"}, {"family": "Pospiech", "given": "Ewelina", "initials": "E"}, {"family": "Branicki", "given": "Wojciech", "initials": "W"}, {"family": "Venkateswaran", "given": "Kasthuri", "initials": "K"}, {"family": "Prithiviraj", "given": "Bharath", "initials": "B"}, {"family": "Dhamodharan", "given": "Ramasamy", "initials": "R"}, {"family": "Udekwu", "given": "Klas", "initials": "K"}, {"family": "Nunes", "given": "Diana", "initials": "D"}, {"family": "Carraro", "given": "Dirce", "initials": "D"}, {"family": "Mason", "given": "Christopher", "initials": "C"}, {"family": "Labaj", "given": "Pawel", "initials": "P"}, {"family": "Silva", "given": "Israel", "initials": "I"}, {"family": "Dias-Neto", "given": "Emmanuel", "initials": "E"}], "type": "posted-content", "published": "2020-12-11", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.10.20236943", "pmid": null, "labels": {"Category: Genomics & transcriptomics": null, "Type: Preprint": null}, "xrefs": [], "notes": [], "created": "2020-12-13T07:59:44.049Z", "modified": "2021-03-10T15:25:26.218Z"}, {"entity": "publication", "iuid": "9464140b8b6d4cc6b78280e9bf8d918b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9464140b8b6d4cc6b78280e9bf8d918b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9464140b8b6d4cc6b78280e9bf8d918b"}}, "title": "Picomolar SARS-CoV-2 Neutralization Using Multi-Arm PEG Nanobody Constructs.", "authors": [{"family": "Moliner-Morro", "given": "Ainhoa", "initials": "A"}, {"family": "J Sheward", "given": "Daniel", "initials": "D"}, {"family": "Karl", "given": "Vivien", "initials": "V"}, {"family": "Perez Vidakovics", "given": "Laura", "initials": "L"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}, {"family": "Hanke", "given": "Leo", "initials": "L"}], "type": "journal article", "published": "2020-12-11", "journal": {"title": "Biomolecules", "issn": "2218-273X", "issn-l": null, "volume": "10", "issue": "12", "pages": null}, "abstract": "Multivalent antibody constructs have a broad range of clinical and biotechnological applications. Nanobodies are especially useful as components for multivalent constructs as they allow increased valency while maintaining a small molecule size. We here describe a novel, rapid method for the generation of bi- and multivalent nanobody constructs with oriented assembly by Cu-free strain promoted azide-alkyne click chemistry (SPAAC). We used sortase A for ligation of click chemistry functional groups site-specifically to the C-terminus of nanobodies before creating C-to-C-terminal nanobody fusions and 4-arm polyethylene glycol (PEG) tetrameric nanobody constructs. We demonstrated the viability of this approach by generating constructs with the SARS-CoV-2 neutralizing nanobody Ty1. We compared the ability of the different constructs to neutralize SARS-CoV-2 pseudotyped virus and infectious virus in neutralization assays. The generated dimers neutralized the virus similarly to a nanobody-Fc fusion variant, while a 4-arm PEG based tetrameric Ty1 construct dramatically enhanced neutralization of SARS-CoV-2, with an IC 50 in the low picomolar range.", "doi": "10.3390/biom10121661", "pmid": "33322557", "labels": {"Type: Journal article": null, "Funder: H2020": null, "Funder: VR: Special COVID-19 funding": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Proteins": null}, "xrefs": [{"db": "pii", "key": "biom10121661"}], "notes": [], "created": "2020-12-18T07:54:12.206Z", "modified": "2021-02-26T08:47:18.845Z"}, {"entity": "publication", "iuid": "ddbdaab95394488cbf53747695bea4e4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ddbdaab95394488cbf53747695bea4e4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ddbdaab95394488cbf53747695bea4e4"}}, "title": "Genetic mechanisms of critical illness in Covid-19.", "authors": [{"family": "Pairo-Castineira", "given": "Erola", "initials": "E"}, {"family": "Clohisey", "given": "Sara", "initials": "S"}, {"family": "Klaric", "given": "Lucija", "initials": "L"}, {"family": "Bretherick", "given": "Andrew D", "initials": "AD"}, {"family": "Rawlik", "given": "Konrad", "initials": "K"}, {"family": "Pasko", "given": "Dorota", "initials": "D"}, {"family": "Walker", "given": "Susan", "initials": "S"}, {"family": "Parkinson", "given": "Nick", "initials": "N"}, {"family": "Fourman", "given": "Max Head", "initials": "MH"}, {"family": "Russell", "given": "Clark D", "initials": "CD"}, {"family": "Furniss", "given": "James", "initials": "J"}, {"family": "Richmond", "given": "Anne", "initials": "A"}, {"family": "Gountouna", "given": "Elvina", "initials": "E"}, {"family": "Wrobel", "given": "Nicola", "initials": "N"}, {"family": "Harrison", "given": "David", "initials": "D"}, {"family": "Wang", "given": "Bo", "initials": "B"}, {"family": "Wu", "given": "Yang", "initials": "Y"}, {"family": "Meynert", "given": "Alison", "initials": "A"}, {"family": "Griffiths", "given": "Fiona", "initials": "F"}, {"family": "Oosthuyzen", "given": "Wilna", "initials": "W"}, {"family": "Kousathanas", "given": "Athanasios", "initials": "A"}, {"family": "Moutsianas", "given": "Loukas", "initials": "L"}, {"family": "Yang", "given": "Zhijian", "initials": "Z"}, {"family": "Zhai", "given": "Ranran", "initials": "R"}, {"family": "Zheng", "given": "Chenqing", "initials": "C"}, {"family": "Grimes", "given": "Graeme", "initials": "G"}, {"family": "Beale", "given": "Rupert", "initials": "R"}, {"family": "Millar", "given": "Jonathan", "initials": "J"}, {"family": "Shih", "given": "Barbara", "initials": "B"}, {"family": "Keating", "given": "Sean", "initials": "S"}, {"family": "Zechner", "given": "Marie", "initials": "M"}, {"family": "Haley", "given": "Chris", "initials": "C"}, {"family": "Porteous", "given": "David J", "initials": "DJ"}, {"family": "Hayward", "given": "Caroline", "initials": "C"}, {"family": "Yang", "given": "Jian", "initials": "J"}, {"family": "Knight", "given": "Julian", "initials": "J"}, {"family": "Summers", "given": "Charlotte", "initials": "C"}, {"family": "Shankar-Hari", "given": "Manu", "initials": "M"}, {"family": "Klenerman", "given": "Paul", "initials": "P"}, {"family": "Turtle", "given": "Lance", "initials": "L"}, {"family": "Ho", "given": "Antonia", "initials": "A"}, {"family": "Moore", "given": "Shona C", "initials": "SC"}, {"family": "Hinds", "given": "Charles", "initials": "C"}, {"family": "Horby", "given": "Peter", "initials": "P"}, {"family": "Nichol", "given": "Alistair", "initials": "A"}, {"family": "Maslove", "given": "David", "initials": "D"}, {"family": "Ling", "given": "Lowell", "initials": "L"}, {"family": "McAuley", "given": "Danny", "initials": "D"}, {"family": "Montgomery", "given": "Hugh", "initials": "H"}, {"family": "Walsh", "given": "Timothy", "initials": "T"}, {"family": "Pereira", "given": "Alex", "initials": "A"}, {"family": "Renieri", "given": "Alessandra", "initials": "A"}, {"family": "GenOMICC Investigators", "given": "", "initials": ""}, {"family": "ISARICC Investigators", "given": "", "initials": ""}, {"family": "COVID-19 Human Genetics Initiative", "given": "", "initials": ""}, {"family": "23andMe Investigators", "given": "", "initials": ""}, {"family": "BRACOVID Investigators", "given": "", "initials": ""}, {"family": "Gen-COVID Investigators", "given": "", "initials": ""}, {"family": "Shen", "given": "Xia", "initials": "X"}, {"family": "Ponting", "given": "Chris P", "initials": "CP"}, {"family": "Fawkes", "given": "Angie", "initials": "A"}, {"family": "Tenesa", "given": "Albert", "initials": "A"}, {"family": "Caulfield", "given": "Mark", "initials": "M"}, {"family": "Scott", "given": "Richard", "initials": "R"}, {"family": "Rowan", "given": "Kathy", "initials": "K"}, {"family": "Murphy", "given": "Lee", "initials": "L"}, {"family": "Openshaw", "given": "Peter J M", "initials": "PJM"}, {"family": "Semple", "given": "Malcolm G", "initials": "MG"}, {"family": "Law", "given": "Andrew", "initials": "A"}, {"family": "Vitart", "given": "Veronique", "initials": "V"}, {"family": "Wilson", "given": "James F", "initials": "JF"}, {"family": "Baillie", "given": "J Kenneth", "initials": "JK"}], "type": "journal article", "published": "2020-12-11", "journal": {"title": "Nature", "issn": "1476-4687", "volume": null, "issue": null, "issn-l": "0028-0836"}, "abstract": "Host-mediated lung inflammation is present, 1 and drives mortality,2 in critical illness caused by Covid-19. Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development.3 Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study(GWAS) in 2244 critically ill Covid-19 patients from 208 UK intensive care units (ICUs). We identify and replicate novel genome-wide significant associations, on chr12q24.13 (rs10735079, p=1.65 [Formula: see text] 10-8) in a gene cluster encoding antiviral restriction enzyme activators (OAS1, OAS2, OAS3), on chr19p13.2 (rs2109069, p=2.3 [Formula: see text] 10-12) near the gene encoding tyrosine kinase 2 (TYK2), on chr19p13.3 (rs2109069, p=3.98 [Formula: see text] 10-12) within the gene encoding dipeptidyl peptidase 9 (DPP9), and on chr21q22.1 (rs2236757, p=4.99 [Formula: see text] 10-8) in the interferon receptor gene IFNAR2. We identify potential targets for repurposing of licensed medications: using Mendelian randomisation we found evidence in support of a causal link from low expression of IFNAR2, and high expression of TYK2, to life-threatening disease; transcriptome-wide association in lung tissue revealed that high expression of the monocyte/macrophage chemotactic receptor CCR2 is associated with severe Covid-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms, and mediators of inflammatory organ damage in Covid-19. Both mechanisms may be amenable to targeted treatment with existing drugs. Large-scale randomised clinical trials will be essential before any change to clinical practice.", "doi": "10.1038/s41586-020-03065-y", "pmid": "33307546", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null}, "xrefs": [], "notes": [], "created": "2020-12-13T07:06:59.152Z", "modified": "2021-02-26T08:45:14.476Z"}, {"entity": "publication", "iuid": "7fe2976d7ac044c290eda708d6c87267", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7fe2976d7ac044c290eda708d6c87267.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7fe2976d7ac044c290eda708d6c87267"}}, "title": "Serum neopterin levels in relation to mild and severe COVID-19", "authors": [{"family": "Robertson", "given": "Josefina", "initials": "J"}, {"family": "Gostner", "given": "Johanna M", "initials": "JM"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "L"}, {"family": "Fuchs", "given": "Dietmar", "initials": "D"}, {"family": "Gisslen", "given": "Magnus", "initials": "M"}], "type": "posted-content", "published": "2020-12-10", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "issn-l": null, "volume": "Dec 10; 20", "issue": "1", "pages": "942"}, "abstract": "Background The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, is rapidly spreading worldwide. There is limited information about prognostic markers that could help clinicians to identify COVID-19 patients with a poor prognosis. Serum levels of the immune activation marker neopterin has shown to be of prognostic value in patients with SARS. The aim of this study was to investigate whether serum neopterin is associated with the severity of COVID-19. Methods We included 34 patients with confirmed COVID-19 between March 3 and March 30, 2020. Fifteen patients had mild disease and did not require hospitalization, whereas 19 patients developed severe COVID-19 requiring intensive care. Concentrations of serum neopterin, tryptophan, and kynurenine were measured at and repeatedly after inclusion. Results We found a more than two-fold higher mean concentration of neopterin in severely ill patients (mean value 42.0 nmol/L (SD 18.2)) compared to patients with mild symptoms (16.9 nmol/L (SD 11.0)). All of the severe cases had elevated neopterin concentrations (>9.1 nmol/L) at the initial sampling with values ranging from 17.2 to 86.7 nmol/L. In comparison, 10 of 15 patients with mild disease had neopterin levels above 9.1 nmol/L, with concentrations in the range from 4.9 to 31.6 nmol/L. Neopterin levels gradually decreased during the course of COVID-19, but severe cases maintained elevated levels for a longer period. Moreover, lower levels of tryptophan and higher levels of kynurenine, indicating an increased tryptophan catabolism, were seen in the group with severe cases. Conclusions In conclusion, we found that serum neopterin levels are associated with the severity of COVID-19. Our findings suggest that neopterin could be used as a prognostic marker, but further studies are needed to elucidate how it can be used in clinical praxis.", "doi": "10.1186/s12879-020-05671-7", "pmid": "33302893", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Research Area: Biomarkers and systems immunology": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-10-30T11:40:52.446Z", "modified": "2021-06-13T05:56:58.395Z"}, {"entity": "publication", "iuid": "d3008d631eca40d0be03bf85943fe585", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3008d631eca40d0be03bf85943fe585.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3008d631eca40d0be03bf85943fe585"}}, "title": "Public perceptions of multiple risks during the COVID-19 pandemic in Italy and Sweden.", "authors": [{"family": "Mondino", "given": "Elena", "initials": "E"}, {"family": "Di Baldassarre", "given": "Giuliano", "initials": "G"}, {"family": "M\u00e5rd", "given": "Johanna", "initials": "J"}, {"family": "Ridolfi", "given": "Elena", "initials": "E"}, {"family": "Rusca", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2020-12-10", "journal": {"title": "Sci Data", "issn": "2052-4463", "volume": "7", "issue": "1", "pages": "434", "issn-l": null}, "abstract": "Knowing how people perceive multiple risks is essential to the management and promotion of public health and safety. Here we present a dataset based on a survey (N = 4,154) of public risk perception in Italy and Sweden during the COVID-19 pandemic. Both countries were heavily affected by the first wave of infections in Spring 2020, but their governmental responses were very different. As such, the dataset offers unique opportunities to investigate the role of governmental responses in shaping public risk perception. In addition to epidemics, the survey considered indirect effects of COVID-19 (domestic violence, economic crises), as well as global (climate change) and local (wildfires, floods, droughts, earthquakes, terror attacks) threats. The survey examines perceived likelihoods and impacts, individual and authorities' preparedness and knowledge, and socio-demographic indicators. Hence, the resulting dataset has the potential to enable a plethora of analyses on social, cultural and institutional factors influencing the way in which people perceive risk.", "doi": "10.1038/s41597-020-00778-7", "pmid": "33303742", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41597-020-00778-7"}, {"db": "URL", "key": "https://doi.org/10.5281/zenodo.4034276", "description": "Raw dataset: perceived likelihoods and impacts, individual and authorities\u2019 preparedness and knowledge, socio-demographic characteristics (N=2,033 in Italy, N=2,121 in Sweden)"}], "notes": [], "created": "2020-12-13T07:21:54.602Z", "modified": "2021-02-26T08:47:00.220Z"}, {"entity": "publication", "iuid": "d8a6f0a2b02147618996bed9adb324bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d8a6f0a2b02147618996bed9adb324bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d8a6f0a2b02147618996bed9adb324bf"}}, "title": "Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses", "authors": [{"family": "Tampere", "given": "Marianna", "initials": "M"}, {"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Salata", "given": "Cristiano", "initials": "C"}, {"family": "Wallner", "given": "Olov", "initials": "O"}, {"family": "Koolmeister", "given": "Tobias", "initials": "T"}, {"family": "Cazares-K\u00f6rner", "given": "Armando", "initials": "A"}, {"family": "Visnes", "given": "Torkild", "initials": "T"}, {"family": "Hesselman", "given": "Maria Carmen", "initials": "MC"}, {"family": "Kunold", "given": "Elena", "initials": "E"}, {"family": "Wiita", "given": "Elisee", "initials": "E"}, {"family": "Kalder\u00e9n", "given": "Christina", "initials": "C"}, {"family": "Lightowler", "given": "Molly", "initials": "M"}, {"family": "Jemth", "given": "Ann Sofie", "initials": "AS"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J"}, {"family": "Rosenquist", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Warpman-Berglund", "given": "Ulrika", "initials": "U"}, {"family": "Helleday", "given": "Thomas", "initials": "T"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Jafari", "given": "Rozbeh", "initials": "R"}, {"family": "Puumalainen", "given": "Marjo Riitta", "initials": "MR"}], "type": "journal-article", "published": "2020-12-10", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "12", "issue": "12", "pages": "1423"}, "abstract": null, "doi": "10.3390/v12121423", "pmid": null, "labels": {"Funder: VR": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Category: Drug Discovery": null, "Category: Proteins": null}, "xrefs": [{"db": "URL", "key": "https://www.mdpi.com/1999-4915/12/12/1423/s1", "description": "Antiviral screening; Dose-response treatment of TH6744 and TH3289; List of proteins from 2D-TPP analysis in U87 cells (FDR); List of proteins from 2D-TPP analysis in U87 cells (Fold-change); Uniprot annotation of overlapping TPP-TR and 2D-TPP hits"}, {"db": "URL", "key": "https://doi.org/10.17044/scilifelab.13089023", "description": "Thermal Proteome Profiling dataset from Hazara virus infected SW13 cells"}, {"db": "URL", "key": "http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD021494", "description": "Raw mass spectrometry data were deposited in the ProteomeXchange Consortium (accession: PXD021494)"}], "notes": [], "created": "2020-12-15T10:44:22.469Z", "modified": "2021-11-18T10:43:13.213Z"}, {"entity": "publication", "iuid": "da568203ba764ebf94e393dfa8ffe7f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/da568203ba764ebf94e393dfa8ffe7f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/da568203ba764ebf94e393dfa8ffe7f9"}}, "title": "Variable sensitivity in molecular detection of SARS-CoV-2 in European Expert Laboratories: External Quality Assessment, June - July 2020.", "authors": [{"family": "Fischer", "given": "Carlo", "initials": "C"}, {"family": "M\u00f6gling", "given": "Ramona", "initials": "R"}, {"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "K\u00fchne", "given": "Arne", "initials": "A"}, {"family": "Oliveira-Filho", "given": "Edmilson F", "initials": "EF"}, {"family": "Wolff", "given": "Thorsten", "initials": "T"}, {"family": "Reiche", "given": "Janine", "initials": "J"}, {"family": "Broberg", "given": "Eeva", "initials": "E"}, {"family": "Meijer", "given": "Adam", "initials": "A"}, {"family": "Leitmeyer", "given": "Katrin", "initials": "K"}, {"family": "Drexler", "given": "Jan Felix", "initials": "JF"}, {"family": "Reusken", "given": "Chantal B E M", "initials": "CBEM"}], "type": "journal article", "published": "2020-12-09", "journal": {"title": "J Clin Microbiol", "issn": "1098-660X", "volume": null, "issue": null, "issn-l": null}, "abstract": "Objective: During the ongoing coronavirus disease 2019 (COVID-19) outbreak, robust detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a key element for clinical management and to interrupt transmission chains. We organized an external quality assessment (EQA) of molecular detection of SARS-CoV-2 for European expert laboratories.Study design: An EQA panel composed of 12 samples, containing either SARS-CoV-2 at different concentrations to evaluate sensitivity or other respiratory viruses to evaluate specificity of SARS-CoV-2 testing, was distributed to 68 laboratories in 35 countries. Specificity samples included seasonal human coronaviruses hCoV-229E, hCoV-NL63 and hCoV-OC43, as well as MERS-CoV, SARS-CoV and human influenza virus A and B.Conclusion: Sensitivity was variable among laboratories, particularly for low concentration SARS-CoV-2 samples. Results indicated that performance was mostly independent of the selection of specific extraction or PCR methods.", "doi": "10.1128/JCM.02676-20", "pmid": "33298612", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "JCM.02676-20"}], "notes": [], "created": "2020-12-21T10:24:12.977Z", "modified": "2020-12-21T10:24:18.568Z"}, {"entity": "publication", "iuid": "7bc8cd7ed5a147eaad1edb24379e7c5a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7bc8cd7ed5a147eaad1edb24379e7c5a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7bc8cd7ed5a147eaad1edb24379e7c5a"}}, "title": "SARS-CoV-2 Spike protein binds to bacterial lipopolysaccharide and boosts proinflammatory activity.", "authors": [{"family": "Petruk", "given": "Ganna", "initials": "G"}, {"family": "Puthia", "given": "Manoj", "initials": "M"}, {"family": "Petrlova", "given": "Jitka", "initials": "J"}, {"family": "Samsudin", "given": "Firdaus", "initials": "F"}, {"family": "Str\u00f6mdahl", "given": "Ann-Charlotte", "initials": "A"}, {"family": "Cerps", "given": "Samuel", "initials": "S"}, {"family": "Uller", "given": "Lena", "initials": "L"}, {"family": "Kjellstr\u00f6m", "given": "Sven", "initials": "S"}, {"family": "Bond", "given": "Peter J", "initials": "PJ"}, {"family": "Schmidtchen", "given": "Artur", "initials": "A"}], "type": "journal article", "published": "2020-12-09", "journal": {"title": "J Mol Cell Biol", "issn": "1759-4685", "issn-l": null, "volume": "12", "issue": "12", "pages": "916-932"}, "abstract": "There is a link between high lipopolysaccharide (LPS) levels in the blood and the metabolic syndrome, and metabolic syndrome predisposes patients to severe COVID-19. Here, we define an interaction between SARS-CoV-2 Spike (S) protein and LPS, leading to aggravated inflammation in vitro and in vivo. Native gel electrophoresis demonstrated that SARS-CoV-2 S protein binds to LPS. Microscale thermophoresis yielded a KD of \u223c47 nM for the interaction. Computational modeling and all-atom molecular dynamics simulations further substantiated the experimental results, identifying a main LPS binding site in SARS-CoV-2 S protein. S protein, when combined with low levels of LPS, boosted nuclear factor-kappa B (NF-\u03baB) activation in monocytic THP-1 cells and cytokine responses in human blood and peripheral blood mononuclear cells, respectively. The in vitro inflammatory response was further validated by employing NF-\u03baB reporter mice and in vivo bioimaging. Dynamic light scattering, transmission electron microscopy, and LPS-FITC analyses demonstrated that S protein modulated the aggregation state of LPS, providing a molecular explanation for the observed boosting effect. Taken together, our results provide an interesting molecular link between excessive inflammation during infection with SARS-CoV-2 and comorbidities involving increased levels of bacterial endotoxins.", "doi": "10.1093/jmcb/mjaa067", "pmid": "33295606", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "6028992"}], "notes": [], "created": "2020-12-10T09:10:19.161Z", "modified": "2021-04-23T14:37:52.421Z"}, {"entity": "publication", "iuid": "cc5b5a5b202d4a13a3a6e430695e4976", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc5b5a5b202d4a13a3a6e430695e4976.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc5b5a5b202d4a13a3a6e430695e4976"}}, "title": "Positive correlation between long term emission of several air pollutants and COVID-19 deaths in Sweden", "authors": [{"family": "Helander", "given": "Lars", "initials": "L"}], "type": "posted-content", "published": "2020-12-09", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.05.20244418", "pmid": null, "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-03-25T14:03:24.020Z", "modified": "2021-03-29T10:10:22.147Z"}, {"entity": "publication", "iuid": "d4e70020cceb46fab1a1a5d44e34e9ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4e70020cceb46fab1a1a5d44e34e9ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4e70020cceb46fab1a1a5d44e34e9ae"}}, "title": "Public health emergencies of international concern: a historic overview.", "authors": [{"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Osman", "given": "Sarah", "initials": "S"}], "type": "journal article", "published": "2020-12-08", "journal": {"title": "J Travel Med", "issn": "1708-8305", "volume": "27", "issue": "8", "issn-l": null}, "abstract": "The International Health Regulations (IHR) have been the governing framework for global health security since 2007. Declaring public health emergencies of international concern (PHEIC) is a cornerstone of the IHR. Here we review how PHEIC are formally declared, the diseases for which such declarations have been made from 2007 until 2020 and justifications for such declarations.\n\nSix events were declared PHEIC between 2007 and 2020: the 2009 H1N1 influenza pandemic, Ebola (West African outbreak 2013-2015, outbreak in Democratic Republic of Congo 2018-2020), poliomyelitis (2014 to present), Zika (2016) and COVID-19 (2020 to present). Poliomyelitis is the longest PHEIC. Zika was the first PHEIC for an arboviral disease. For several other emerging diseases a PHEIC was not declared despite the fact that the public health impact of the event was considered serious and associated with potential for international spread.\n\nThe binary nature of a PHEIC declaration is often not helpful for events where a tiered or graded approach is needed. The strength of PHEIC declarations is the ability to rapidly mobilize international coordination, streamline funding and accelerate the advancement of the development of vaccines, therapeutics and diagnostics under emergency use authorization. The ultimate purpose of such declaration is to catalyse timely evidence-based action, to limit the public health and societal impacts of emerging and re-emerging disease risks while preventing unwarranted travel and trade restrictions.", "doi": "10.1093/jtm/taaa227", "pmid": "33284964", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "6025447"}], "notes": [], "created": "2020-12-10T09:16:43.061Z", "modified": "2021-01-22T09:25:37.994Z"}, {"entity": "publication", "iuid": "a5bc184f74d94abaaf2126638eb17ffa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a5bc184f74d94abaaf2126638eb17ffa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a5bc184f74d94abaaf2126638eb17ffa"}}, "title": "Protective role of tacrolimus, deleterious role of age and comorbidities in liver transplant recipients with Covid-19: results from the ELITA/ELTR multi-center European study.", "authors": [{"family": "Belli", "given": "Luca S", "initials": "LS"}, {"family": "Fondevila", "given": "Constantino", "initials": "C"}, {"family": "Cortesi", "given": "Paolo A", "initials": "PA"}, {"family": "Conti", "given": "Sara", "initials": "S"}, {"family": "Karam", "given": "Vincent", "initials": "V"}, {"family": "Adam", "given": "Rene", "initials": "R"}, {"family": "Coilly", "given": "Audrey", "initials": "A"}, {"family": "Ericzon", "given": "Bo Goran", "initials": "BG"}, {"family": "Loinaz", "given": "Carmelo", "initials": "C"}, {"family": "Cuervas-Mons", "given": "Valentin", "initials": "V"}, {"family": "Zambelli", "given": "Marco", "initials": "M"}, {"family": "Llado", "given": "Laura", "initials": "L"}, {"family": "Diaz", "given": "Fernando", "initials": "F"}, {"family": "Invernizzi", "given": "Federica", "initials": "F"}, {"family": "Patrono", "given": "Damiano", "initials": "D"}, {"family": "Faitot", "given": "Francois", "initials": "F"}, {"family": "Bhooori", "given": "Sherrie", "initials": "S"}, {"family": "Pirenne", "given": "Jacques", "initials": "J"}, {"family": "Perricone", "given": "Giovanni", "initials": "G"}, {"family": "Magini", "given": "Giulia", "initials": "G"}, {"family": "Castells", "given": "LLuis", "initials": "L"}, {"family": "Detry", "given": "Oliver", "initials": "O"}, {"family": "Cruchaga", "given": "Pablo Mart", "initials": "PM"}, {"family": "Colmenero", "given": "Jordi", "initials": "J"}, {"family": "Berrevoet", "given": "Frederick", "initials": "F"}, {"family": "Rodriguez", "given": "Gonzalo", "initials": "G"}, {"family": "Ysebaert", "given": "Dirk", "initials": "D"}, {"family": "Radenne", "given": "Sylvie", "initials": "S"}, {"family": "Metselaar", "given": "Herold", "initials": "H"}, {"family": "Morelli", "given": "Cristina", "initials": "C"}, {"family": "De Carlis", "given": "Luciano", "initials": "L"}, {"family": "Polak", "given": "Wojciech G", "initials": "WG"}, {"family": "Duvoux", "given": "Christophe", "initials": "C"}, {"family": "all the centres contributing to the ELITA-ELTR COVID-19 Registry", "given": "", "initials": ""}], "type": "journal article", "published": "2020-12-08", "journal": {"title": "Gastroenterology", "issn": "1528-0012", "volume": null, "issue": null, "issn-l": null}, "abstract": "Despite concerns that liver transplant (LT) recipients may be at increased risk of unfavorable outcomes from COVID-19 due the high prevalence of co-morbidities, immunosuppression and ageing, a detailed analysis of their effects in large studies is lacking METHODS: Data from adult LT recipients with laboratory confirmed SARS-CoV2 infection were collected across Europe. All consecutive patients with symptoms were included in the analysis, RESULTS: Between March 1st and June 27 th2020, data from 243 adult symptomatic cases from 36 centers and 9 countries were collected. Thirty-nine (16%) were managed as outpatients while 204 (84%) required hospitalization including admission to the ICU (39/204, 19.1%). Forty-nine (20.2%) patients died after a median of 13.5 (10-23) days, respiratory failure was the major cause. After multivariable Cox regression analysis, age > 70 (HR 4.16; 95%CI 1.78-9.73) had a negative effect and tacrolimus (TAC) use (HR 0.55; 95%CI 0.31-0.99) had a positive independent effect on survival. The role of co-morbidities was strongly influenced by the dominant effect of age where comorbidities increased with the increasing age of the recipients. In a second model excluding age, both diabetes (HR 1.95; 95%CI 1.06 - 3.58) and chronic kidney disease (HR 1.97; 95%CI 1.05 - 3.67) emerged as associated with death CONCLUSIONS: Twenty-five per cent of patients requiring hospitalization for Covid-19 died, the risk being higher in patients older than 70 and with medical co-morbidities, such as impaired renal function and diabetes. Conversely, the use of TAC was associated with a better survival thus encouraging clinicians to keep TAC at the usual dose.", "doi": "10.1053/j.gastro.2020.11.045", "pmid": "33307029", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S0016-5085(20)35514-1"}], "notes": [], "created": "2020-12-13T07:08:28.389Z", "modified": "2021-02-26T08:45:03.178Z"}, {"entity": "publication", "iuid": "dd16fa9a8be04f01a74a4ac5d1cd3863", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dd16fa9a8be04f01a74a4ac5d1cd3863.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dd16fa9a8be04f01a74a4ac5d1cd3863"}}, "title": "No impact of cancer and plague-relevant FPR1 polymorphisms on COVID-19.", "authors": [{"family": "Petrazzuolo", "given": "Adriana", "initials": "A"}, {"family": "Le Naour", "given": "Julie", "initials": "J"}, {"family": "Vacchelli", "given": "Erika", "initials": "E"}, {"family": "Gaussem", "given": "Pascale", "initials": "P"}, {"family": "Ellouze", "given": "Syrine", "initials": "S"}, {"family": "Jourdi", "given": "Georges", "initials": "G"}, {"family": "Solary", "given": "Eric", "initials": "E"}, {"family": "Fontenay", "given": "Michaela", "initials": "M"}, {"family": "Smadja", "given": "David M", "initials": "DM"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}], "type": "journal article", "published": "2020-12-08", "journal": {"title": "Oncoimmunology", "issn": "2162-402X", "volume": "9", "issue": "1", "pages": "1857112", "issn-l": "2162-4011"}, "abstract": "Formyl peptide receptor 1 (FPR1) is a pattern-recognition receptor that detects bacterial as well as endogenous danger-associated molecular patterns to trigger innate immune responses by myeloid cells. A single nucleotide polymorphism, rs867228 (allelic frequency 19-20%), in the gene coding for FPR1 accelerates the manifestation of multiple carcinomas, likely due to reduced anticancer immunosurveillance secondary to a defect in antigen presentation by dendritic cells. Another polymorphism in FPR1, rs5030880 (allelic frequency 12-13%), has been involved in the resistance to plague, correlating with the fact that FPR1 is the receptor for Yersinia pestis. Driven by the reported preclinical effects of FPR1 on lung inflammation and fibrosis, we investigated whether rs867228 or rs5030880 would affect the severity of coronavirus disease-19 (COVID-19). Data obtained on patients from two different hospitals in Paris refute the hypothesis that rs867228 or rs5030880 would affect the severity of COVID-19.", "doi": "10.1080/2162402X.2020.1857112", "pmid": "33344044", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "1857112"}, {"db": "pmc", "key": "PMC7734042"}, {"db": "URL", "key": "https://www.tandfonline.com/doi/figure/10.1080/2162402X.2020.1857112?scroll=top&needAccess=true", "description": "Allelic frequencies of FPR1 SNPs and characteristics of patient population from H\u00f4pital Cochin and H\u00f4pital Europ\u00e9en George Pompidou"}], "notes": [], "created": "2021-01-07T09:58:41.553Z", "modified": "2021-11-18T10:35:20.483Z"}, {"entity": "publication", "iuid": "6f826f3022c54f3c9bc2f1833f17a0cd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f826f3022c54f3c9bc2f1833f17a0cd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f826f3022c54f3c9bc2f1833f17a0cd"}}, "title": "Asymptomatic SARS-CoV-2 infection: Is it all about being refractile to innate immune sensing of viral spare-parts? - Clues from exotic animal reservoirs.", "authors": [{"family": "Shankar", "given": "Esaki M", "initials": "EM"}, {"family": "Che", "given": "Karlhans F", "initials": "KF"}, {"family": "Yong", "given": "Yean K", "initials": "YK"}, {"family": "Girija", "given": "A S Smiline", "initials": "ASS"}, {"family": "Velu", "given": "Vijayakumar", "initials": "V"}, {"family": "Ansari", "given": "Abdul W", "initials": "AW"}, {"family": "Larsson", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2020-12-08", "journal": {"title": "Pathog Dis", "issn": "2049-632X", "issn-l": null, "volume": "79", "issue": "1", "pages": null}, "abstract": "A vast proportion of coronavirus disease 2019 (COVID-19) individuals remain asymptomatic and can shed severe acute respiratory syndrome (SARS-CoV) type 2 virus to transmit the infection, which also explains the exponential increase in the number of COVID-19 cases globally. Furthermore, the rate of recovery rates from clinical COVID-19 in certain pockets of the globe is surprisingly high. Based on published reports and available literature, here, we speculated a few immunovirological mechanisms as to why a vast majority of individuals remain asymptomatic similar to exotic animal (bats and pangolins) reservoirs that remain refractile to disease development despite carrying a huge load of diverse insidious viral species, and whether such evolutionary advantage would unveil therapeutic strategies against human COVID-19 infection. Understanding the unique mechanisms that exotic animal species employ to achieve viral control, as well as inflammatory regulation, appears to hold key clues to the development of therapeutic versatility against COVID-19.", "doi": "10.1093/femspd/ftaa076", "pmid": "33289808", "labels": {"Funder: KAW/SciLifeLab": null, "Type: Review": null, "Research Area: Biomarkers and systems immunology": null}, "xrefs": [{"db": "pii", "key": "6027506"}], "notes": [], "created": "2020-12-10T09:14:38.546Z", "modified": "2021-06-13T05:58:21.495Z"}, {"entity": "publication", "iuid": "2e1039d1c30f4e3e969ab8ed6afe7d20", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e1039d1c30f4e3e969ab8ed6afe7d20.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e1039d1c30f4e3e969ab8ed6afe7d20"}}, "title": "Nitric oxide's physiologic effects and potential as a therapeutic agent against COVID-19.", "authors": [{"family": "Ricciardolo", "given": "Fabio Luigi Massimo", "initials": "FLM"}, {"family": "Bertolini", "given": "Francesca", "initials": "F"}, {"family": "Carriero", "given": "Vitina", "initials": "V"}, {"family": "H\u00f6gman", "given": "Marieann", "initials": "M", "orcid": "0000-0002-6392-6092", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/86cdb5ef5c2e48d886bc443db7f3b64e.json"}}], "type": "journal article", "published": "2020-12-05", "journal": {"title": "J Breath Res", "issn": "1752-7163", "volume": "15", "issue": "1", "pages": "014001", "issn-l": "1752-7155"}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for COVID-19 pneumonia, a pandemic that precipitates huge pressures on the world's social and economic systems. Disease severity varies among individuals. SARS-CoV-2 infection can be associated with e.g. flu-like symptoms, dyspnoea, severe interstitial pneumonia, acute respiratory distress syndrome, multiorgan dysfunction, and generalized coagulopathy. Nitric oxide (NO), is a small signal molecule that impacts pleiotropic functions in human physiology, which can be involved in the significant effects of COVID-19 infection. NO is a neurotransmitter involved in the neural olfactory processes in the central nervous system, and some infected patients have reported anosmia as a symptom. Additionally, NO is a well-known vasodilator, important coagulation mediator, anti-microbial effector and inhibitor of SARS-CoV replication. Exhaled NO is strongly related to the type-2 inflammatory response found in asthma, which has been suggested to be protective against SARS-CoV-2 infection. Several reports indicate that the use of inhaled NO has been an effective therapy during this pandemic since the ventilation-perfusion ratio in COVID-19 patients improved afterwards and they did not require mechanical ventilation. The aim of this mini-review is to summarize relevant actions of NO that could be beneficial in the treatment of COVID-19.", "doi": "10.1088/1752-7163/abc302", "pmid": "33080582", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-19T19:29:57.613Z", "modified": "2023-01-13T13:43:21.870Z"}, {"entity": "publication", "iuid": "e76a6c0b95dc43c883950fbdbb497773", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e76a6c0b95dc43c883950fbdbb497773.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e76a6c0b95dc43c883950fbdbb497773"}}, "title": "Responsible Gambling Telephone Intervention to High-Risk Gamblers by a State-Owned Gambling Operator in Sweden: Study Protocol for a Study on Effectiveness, User Satisfaction, and Acceptability.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "Franklin", "given": "Katja", "initials": "K"}, {"family": "Dahlstr\u00f6m", "given": "Maria", "initials": "M"}, {"family": "Lyckberg", "given": "Axel", "initials": "A"}], "type": "journal article", "published": "2020-12-04", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "17", "issue": "23", "issn-l": null}, "abstract": "Gambling disorder is associated with severe financial, social, and psychological consequences, but treatment-seeking rates have been described to be low. Apart from formal treatment, motivational interventions in nontreatment-seeking high-risk gamblers have been shown to be promising. However, little is known about the effectiveness and acceptability of such motivational interventions carried out by a gambling operator as part of the company's responsible gambling policies. Early experiences of such interventions are limited by the risk that gambling in individuals reached with the intervention may continue with a different gambling operator. The present study aims to evaluate effectiveness and user acceptability of a responsible gambling intervention continuously carried out by the Swedish state-owned gambling operator Svenska Spel Sport & Casino. This intervention for high-risk gamblers, identified either through substantial monetary losses or through a voluntary self-test by the gambler, includes a motivational telephone intervention aiming to encourage the gambler to set deposit limits, practice self-exclusion, or seek help. This protocol paper describes the two-tailed evaluation of this intervention: (1) A retrospective, register-based study of the effectiveness of the motivational intervention on gambling expenditures, deposit limits, and self-exclusions in comparison to control individuals not reached by the intervention, including all clients reached or attempted to be reached during September 2019-April 2020 (total n = 3626), as well as a one-to-one matched comparison of clients reached (n = 1404) and not reached; and (2) a prospective web survey study in individuals reached by the same ongoing telephone intervention practice from November 2020 (target n = 200), measuring clients' attitudes to the intervention, perceived effects of the intervention on gambling, and their self-reported gambling on all operators after the intervention.", "doi": "10.3390/ijerph17239069", "pmid": "33561040", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "ijerph17239069"}], "notes": [], "created": "2021-02-10T18:44:43.305Z", "modified": "2021-02-26T08:47:00.274Z"}, {"entity": "publication", "iuid": "1d1d051d522c4e08ae59fe3448e9558a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d1d051d522c4e08ae59fe3448e9558a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d1d051d522c4e08ae59fe3448e9558a"}}, "title": "Harnessing the Power of Social Media to Support a Professional Learning Network During the COVID-19 Pandemic.", "authors": [{"family": "Hall", "given": "Elissa", "initials": "E"}, {"family": "Kreuter", "given": "Justin D", "initials": "JD"}, {"family": "S\u00f6r\u00f6", "given": "Teresa", "initials": "T"}, {"family": "Dzara", "given": "Kristina", "initials": "K"}, {"family": "Gooding", "given": "Holly C", "initials": "HC"}], "type": "journal article", "published": "2020-12-04", "journal": {"title": "J Contin Educ Health Prof", "issn": "1554-558X", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1097/CEH.0000000000000326", "pmid": "33290300", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-10T09:13:53.850Z", "modified": "2020-12-10T09:14:04.250Z"}, {"entity": "publication", "iuid": "9ceaca5cb62245e8a1173dd1758a02d2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ceaca5cb62245e8a1173dd1758a02d2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ceaca5cb62245e8a1173dd1758a02d2"}}, "title": "Choir Singers Without Rehearsals and Concerts? A Questionnaire Study on Perceived Losses From Restricting Choral Singing During the Covid-19 Pandemic.", "authors": [{"family": "Theorell", "given": "T\u00f6res", "initials": "T"}, {"family": "Kowalski", "given": "Jan", "initials": "J"}, {"family": "Theorell", "given": "Ann Mari Lind", "initials": "AML"}, {"family": "Horwitz", "given": "Eva Bojner", "initials": "EB"}], "type": "journal article", "published": "2020-12-04", "journal": {"title": "J Voice", "issn": "1873-4588", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Choir singing is an activity that engages individuals all over the world with a broad demographic representation. Both qualitative and quantitative studies have examined the benefits of the activity but very few have examined the effects when someone loses access to it and stops singing.\r\n\r\nExamining the governmental and organisational responses precipitated by the COVID-19 pandemic, we asked what happens when a choir singer loses all of their routines associated with regular participation in choir singing.\r\n\r\nOne national choir organization in Sweden (n = 3163) and one in Norway (n = 1881) were approached with a short survey. This comprised questions relating to the issue \"what do you as a choir singer misses the most?\" Each participant was asked to rate the importance of a number of elements that pertain to the experience of choir singing.\r\n\r\nThe social aspect of singing emerged as having the strongest weight in terms of perceived loss that is, it was the element that the participants missed the most. Professional singers report that they miss the aesthetic experiences, flow, and all the physical aspects (physical training, voice training, and breathing training) to a greater degree as compared to reports from the amateurs. The importance of aesthetic experiences and physical components appeared to rise with increasing number of years that an individual had engaged with choir singing.\r\n\r\nIn the Scandinavian setting, the social aspect has a stronger weight than the other components and this seemed to be more significant in Norway compared to Sweden.", "doi": "10.1016/j.jvoice.2020.11.006", "pmid": "33288380", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0892-1997(20)30422-7"}], "notes": [], "created": "2020-12-10T09:15:41.012Z", "modified": "2022-11-22T05:49:56.111Z"}, {"entity": "publication", "iuid": "ee547b2d04a741ffa826a9ee92b9593c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee547b2d04a741ffa826a9ee92b9593c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee547b2d04a741ffa826a9ee92b9593c"}}, "title": "A Novel Approach to Hematology Testing at the Point of Care.", "authors": [{"family": "Bransky", "given": "Avishay", "initials": "A"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Aardal", "given": "Elisabeth", "initials": "E"}, {"family": "Ben-Yosef", "given": "Yaara", "initials": "Y"}, {"family": "Christenson", "given": "Robert H", "initials": "RH"}], "type": "journal article", "published": "2020-12-04", "journal": {"title": "J Appl Lab Med", "issn": "2576-9456", "volume": null, "issue": null, "issn-l": null}, "abstract": "The need for rapid point-of-care (POC) diagnostics is now becoming more evident due to the increasing need for timely results and improvement in healthcare service. With the recent COVID-19 pandemic outbreak, POC has become critical in managing the spread of disease. Applicable diagnostics should be readily deployable, easy to use, portable, and accurate so that they fit mobile laboratories, pop-up treatment centers, field hospitals, secluded wards within hospitals, or remote regions, and can be operated by staff with minimal training. Complete blood count (CBC), however, has not been available at the POC in a simple-to-use device until recently. The HemoScreen, which was recently cleared by the FDA for POC use, is a miniature, easy-to-use instrument that uses disposable cartridges and may fill this gap.\n\nThe HemoScreen's analysis method, in contrast to standard laboratory analyzers, is based on machine vision (image-based analysis) and artificial intelligence (AI). We discuss the different methods currently used and compare their results to the vision-based one. The HemoScreen is found to correlate well to laser and impedance-based methods while emphasis is given to mean cell volume (MCV), mean cell hemoglobin (MCH), and platelets (PLT) that demonstrate better correlation when the vision-based method is compared to itself due to the essential differences between the underlying technologies.\n\nThe HemoScreen analyzer demonstrates lab equivalent performance, tested at different clinical settings and sample characteristics, and might outperform standard techniques in the presence of certain interferences. This new approach to hematology testing has great potential to improve quality of care in a variety of settings.", "doi": "10.1093/jalm/jfaa186", "pmid": "33274357", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "6020101"}], "notes": [], "created": "2020-12-06T07:07:57.964Z", "modified": "2021-02-26T08:46:13.585Z"}, {"entity": "publication", "iuid": "ae653e3642a04dc0b8c1b2550cb03a7d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ae653e3642a04dc0b8c1b2550cb03a7d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ae653e3642a04dc0b8c1b2550cb03a7d"}}, "title": "Risk perception and determinants in small- and medium-sized agri-food enterprises amidst the COVID-19 pandemic: Evidence from Egypt.", "authors": [{"family": "Abu Hatab", "given": "Assem", "initials": "A"}, {"family": "Lagerkvist", "given": "Carl-Johan", "initials": "CJ"}, {"family": "Esmat", "given": "Abourehab", "initials": "A"}], "type": "journal article", "published": "2020-12-03", "journal": {"title": "Agribusiness (N Y N Y)", "issn": "1520-6297", "volume": null, "issue": null, "issn-l": null}, "abstract": "The coronavirus disease-2019 (COVID-19) pandemic has disrupted many activities along agri-food supply chains in developing countries and posed unprecedented challenges in particular to small and medium agri-food enterprises (SMEs). Drawing on a survey of 166 Egyptian agri-food SMEs, this study investigates differences in- and determinants of COVID-19 business risk perception among these enterprises. The empirical results showed that risk perception was highly asymmetric across geographical regions. Enterprises with longer cash flow coverage periods and higher values of total assets perceived significantly lower risk levels, as cash and assets functioned as a buffer against the impact of COVID-19. The findings of the study imply that the \"just-in-time\" approach and the absence of a proactive and preventative stance to risk management reduced the resilience of agri-food SMEs to the risks presented by the pandemic. Generally, enterprises that operate both in domestic and export markets perceived lower COVID-19 risks. Finally, the main export destination to which the surveyed enterprises export was a significant determinant of their risk perception. These findings could be useful to managers of agri-food businesses in terms of better understanding of risks and promotion of risk management practices. More so, they can help design effective policy interventions to mitigate the impacts of the pandemic on Egyptian agri-food SMEs and build up their resilience to future pandemics and shocks.", "doi": "10.1002/agr.21676", "pmid": "33362335", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "AGR21676"}, {"db": "pmc", "key": "PMC7753412"}], "notes": [], "created": "2021-01-07T13:40:07.426Z", "modified": "2021-01-10T17:25:27.745Z"}, {"entity": "publication", "iuid": "7a0e1b89eac4430dbb65390fb3a90d76", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a0e1b89eac4430dbb65390fb3a90d76.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a0e1b89eac4430dbb65390fb3a90d76"}}, "title": "Patients With COVID-19 Have Elevated Levels of Circulating Extracellular Vesicle Tissue Factor Activity That Is Associated With Severity and Mortality.", "authors": [{"family": "Rosell", "given": "Axel", "initials": "A"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "von Meijenfeldt", "given": "Fien", "initials": "F"}, {"family": "Hisada", "given": "Yohei", "initials": "Y"}, {"family": "Aguilera", "given": "Katherina", "initials": "K"}, {"family": "Grover", "given": "Steven P", "initials": "SP"}, {"family": "Lisman", "given": "Ton", "initials": "T"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2020-12-03", "journal": {"title": "Arterioscler Thromb Vasc Biol", "issn": "1524-4636", "issn-l": null, "volume": "41", "issue": "2", "pages": "ATVBAHA120315547"}, "abstract": "Patients with coronavirus disease 2019 (COVID-19) have a high rate of thrombosis. We hypothesized that severe acute respiratory syndrome coronavirus 2 leads to induction of TF (tissue factor) expression and increased levels of circulating TF-positive extracellular vesicles (EV) that may drive thrombosis. Approach and Results: We measured levels of plasma EV TF activity in 100 patients with COVID-19 with moderate and severe disease and 28 healthy controls. Levels of EV TF activity were significantly higher in patients with COVID-19 compared with controls. In addition, levels of EV TF activity were associated with disease severity and mortality. Finally, levels of EV TF activity correlated with several plasma markers, including D-dimer, which has been shown to be associated with thrombosis in patients with COVID-19.\r\n\r\nOur results indicate that severe acute respiratory syndrome coronavirus 2 infection induces the release of TF-positive EVs into the circulation that are likely to contribute to thrombosis in patients with COVID-19. EV TF activity was also associated with severity and mortality.", "doi": "10.1161/ATVBAHA.120.315547", "pmid": "33267656", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-09T06:14:18.210Z", "modified": "2021-06-13T06:02:55.694Z"}, {"entity": "publication", "iuid": "76d13794cf40457aae8704e08f7676e0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/76d13794cf40457aae8704e08f7676e0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/76d13794cf40457aae8704e08f7676e0"}}, "title": "Helmet continuous positive airway pressure versus high-flow nasal cannula in COVID-19: a pragmatic randomised clinical trial (COVID HELMET).", "authors": [{"family": "Tverring", "given": "Jonas", "initials": "J"}, {"family": "\u00c5kesson", "given": "Anna", "initials": "A"}, {"family": "Nielsen", "given": "Niklas", "initials": "N"}], "type": "journal article", "published": "2020-12-03", "journal": {"title": "Trials", "issn": "1745-6215", "volume": "21", "issue": "1", "pages": "994", "issn-l": null}, "abstract": "Patients with COVID-19 and hypoxaemia despite conventional low-flow oxygen therapy are often treated with high-flow nasal cannula (HFNC) in line with international guidelines. Oxygen delivery by helmet continuous positive airway pressure (CPAP) is a feasible option that enables a higher positive end-expiratory pressure (PEEP) and may theoretically reduce the need for intubation compared to HFNC but direct comparative evidence is lacking.\n\nWe plan to perform an investigator-initiated, pragmatic, randomised trial at an intermediate-level COVID-19 cohort ward in Helsingborg Hospital, southern Sweden. We have estimated a required sample size of 120 patients randomised 1:1 to HFNC or Helmet CPAP to achieve 90% power to detect superiority at a 0.05 significance level regarding the primary outcome of ventilator free days (VFD) within 28 days using a Mann-Whitney U test. Patient recruitment is planned to being June 2020 and be completed in the first half of 2021.\n\nWe hypothesise that the use of Helmet CPAP will reduce the need for invasive mechanical ventilation compared to the use of HFNC without having a negative effect on survival. This could have important implications during the current COVID-19 epidemic.\n\nClinicalTrials.gov NCT04395807 . Registered on 20 May 2020.", "doi": "10.1186/s13063-020-04863-5", "pmid": "33272319", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13063-020-04863-5"}, {"db": "ClinicalTrials.gov", "key": "NCT04395807"}], "notes": [], "created": "2020-12-06T07:08:35.572Z", "modified": "2021-02-26T08:46:13.272Z"}, {"entity": "publication", "iuid": "d24497021abf4097b4a19066fdd7cdb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d24497021abf4097b4a19066fdd7cdb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d24497021abf4097b4a19066fdd7cdb1"}}, "title": "Clinical characteristics of SARS-CoV-2 infection in children with cystic fibrosis: An international observational study.", "authors": [{"family": "Bain", "given": "Robert", "initials": "R"}, {"family": "Cosgriff", "given": "Rebecca", "initials": "R"}, {"family": "Zampoli", "given": "Marco", "initials": "M"}, {"family": "Elbert", "given": "Alexander", "initials": "A"}, {"family": "Burgel", "given": "Pierre-R\u00e9gis", "initials": "PR"}, {"family": "Carr", "given": "Siobh\u00e1n B", "initials": "SB"}, {"family": "Casta\u00f1os", "given": "Claudio", "initials": "C"}, {"family": "Colombo", "given": "Carla", "initials": "C"}, {"family": "Corvol", "given": "Harriet", "initials": "H"}, {"family": "Faro", "given": "Albert", "initials": "A"}, {"family": "Goss", "given": "Christopher H", "initials": "CH"}, {"family": "Gutierrez", "given": "Hector", "initials": "H"}, {"family": "Jung", "given": "Andreas", "initials": "A"}, {"family": "Kashirskaya", "given": "Nataliya", "initials": "N"}, {"family": "Marshall", "given": "Bruce C", "initials": "BC"}, {"family": "Melo", "given": "Joel", "initials": "J"}, {"family": "Mondejar-Lopez", "given": "Pedro", "initials": "P"}, {"family": "de Monestrol", "given": "Isabelle", "initials": "I"}, {"family": "Naehrlich", "given": "Lutz", "initials": "L"}, {"family": "Pastor-Vivero", "given": "Maria Dolores", "initials": "MD"}, {"family": "Rizvi", "given": "Samar", "initials": "S"}, {"family": "Filho", "given": "Luiz Vicente Ribeiro Ferreira da Silva", "initials": "LVRFDS"}, {"family": "Brownlee", "given": "Keith G", "initials": "KG"}, {"family": "Haq", "given": "Iram J", "initials": "IJ"}, {"family": "Brodlie", "given": "Malcolm", "initials": "M"}], "type": "journal article", "published": "2020-12-03", "journal": {"title": "J Cyst Fibros", "issn": "1873-5010", "volume": null, "issue": null, "issn-l": null}, "abstract": "The presence of co-morbidities, including underlying respiratory problems, has been identified as a risk factor for severe COVID-19 disease. Information on the clinical course of SARS-CoV-2 infection in children with cystic fibrosis (CF) is limited, yet vital to provide accurate advice for children with CF, their families, caregivers and clinical teams.\n\nCases of SARS-CoV-2 infection in children with CF aged less than 18 years were collated by the CF Registry Global Harmonization Group across 13 countries between 1 February and 7 August 2020.\n\nData on 105 children were collated and analysed. Median age of cases was ten years (interquartile range 6-15), 54% were male and median percentage predicted forced expiratory volume in one second was 94% (interquartile range 79-104). The majority (71%) of children were managed in the community during their COVID-19 illness. Out of 24 children admitted to hospital, six required supplementary oxygen and two non-invasive ventilation. Around half were prescribed antibiotics, five children received antiviral treatments, four azithromycin and one additional corticosteroids. Children that were hospitalised had lower lung function and reduced body mass index Z-scores. One child died six weeks after testing positive for SARS-CoV-2 following a deterioration that was not attributed to COVID-19 disease.\n\nSARS-CoV-2 infection in children with CF is usually associated with a mild illness in those who do not have pre-existing severe lung disease.", "doi": "10.1016/j.jcf.2020.11.021", "pmid": "33309057", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1569-1993(20)30931-0"}, {"db": "pmc", "key": "PMC7713571"}], "notes": [], "created": "2020-12-21T10:19:07.648Z", "modified": "2021-02-26T08:47:00.215Z"}, {"entity": "publication", "iuid": "4e5914a83e6b48158f9a6b16ce45f216", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4e5914a83e6b48158f9a6b16ce45f216.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4e5914a83e6b48158f9a6b16ce45f216"}}, "title": "COVID-19 misinformation: Mere harmless delusions or much more? A knowledge and attitude cross-sectional study among the general public residing in Jordan.", "authors": [{"family": "Sallam", "given": "Malik", "initials": "M"}, {"family": "Dababseh", "given": "Deema", "initials": "D"}, {"family": "Yaseen", "given": "Alaa", "initials": "A"}, {"family": "Al-Haidar", "given": "Ayat", "initials": "A"}, {"family": "Taim", "given": "Duaa", "initials": "D"}, {"family": "Eid", "given": "Huda", "initials": "H"}, {"family": "Ababneh", "given": "Nidaa A", "initials": "NA"}, {"family": "Bakri", "given": "Faris G", "initials": "FG"}, {"family": "Mahafzah", "given": "Azmi", "initials": "A"}], "type": "journal article", "published": "2020-12-03", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "15", "issue": "12", "pages": "e0243264"}, "abstract": "Since the emergence of the recent coronavirus disease 2019 (COVID-19) and its spread as a pandemic, media was teeming with misinformation that led to psychologic, social and economic consequences among the global public. Probing knowledge and anxiety regarding this novel infectious disease is necessary to identify gaps in knowledge and sources of misinformation which can help public health efforts to design and implement more focused interventional measures. The aim of this study was to evaluate the knowledge, attitude and effects of misinformation about COVID-19 on anxiety level among the general public residing in Jordan. This cross-sectional study was conducted using an online-based questionnaire that took place in April 2020, which targeted people residing in Jordan, aged 18 and above. The questionnaire included items on the following: demographic characteristics of the participants, knowledge about COVID-19, anxiety level and misconceptions regarding the origin of the pandemic. The total number of participants included in final analysis was 3150. The study population was predominantly females (76.0%), with mean age of 31 years. The overall knowledge of COVID-19 was satisfactory. Older age, males, lower monthly income and educational levels, smoking and history of chronic disease were associated with perceiving COVID-19 as a very dangerous disease. Variables that were associated with a higher anxiety level during the pandemic included: lower monthly income and educational level, residence outside the capital (Amman) and history of smoking. Misinformation about the origin of the pandemic (being part of a conspiracy, biologic warfare and the 5G networks role) was also associated with higher anxiety levels. Social media platforms, TV and news releases were the most common sources of information about the pandemic. The study showed the potential harmful effects of misinformation on the general public and emphasized the need to meticulously deliver timely and accurate information about the pandemic to lessen the health, social and psychological impact of the disease.", "doi": "10.1371/journal.pone.0243264", "pmid": "33270783", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-21682"}], "notes": [], "created": "2020-12-06T07:09:15.849Z", "modified": "2022-11-23T09:03:19.499Z"}, {"entity": "publication", "iuid": "18eed320c23f4102b00dbb87e7e9029b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18eed320c23f4102b00dbb87e7e9029b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18eed320c23f4102b00dbb87e7e9029b"}}, "title": "The Structural Basis of Accelerated Host Cell Entry by SARS-CoV-2 \u2020.", "authors": [{"family": "Seyran", "given": "Murat", "initials": "M"}, {"family": "Takayama", "given": "Kazuo", "initials": "K"}, {"family": "Uversky", "given": "Vladimir N", "initials": "VN"}, {"family": "Lundstrom", "given": "Kenneth", "initials": "K"}, {"family": "Pal\u00f9", "given": "Giorgio", "initials": "G"}, {"family": "Sherchan", "given": "Samendra P", "initials": "SP"}, {"family": "Attrish", "given": "Diksha", "initials": "D"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Aljabali", "given": "Alaa A A", "initials": "AAA"}, {"family": "Ghosh", "given": "Shinjini", "initials": "S"}, {"family": "Pizzol", "given": "Damiano", "initials": "D"}, {"family": "Chauhan", "given": "Gaurav", "initials": "G"}, {"family": "Adadi", "given": "Parise", "initials": "P"}, {"family": "Mohamed Abd El-Aziz", "given": "Tarek", "initials": "T"}, {"family": "Soares", "given": "Antonio G", "initials": "AG"}, {"family": "Kandimalla", "given": "Ramesh", "initials": "R"}, {"family": "Tambuwala", "given": "Murtaza", "initials": "M"}, {"family": "Sarif Hassan", "given": "Sk", "initials": "S"}, {"family": "Kumar Azad", "given": "Gajendra", "initials": "G"}, {"family": "Pal Choudhury", "given": "Pabitra", "initials": "P"}, {"family": "Baetas-da-Cruz", "given": "Wagner", "initials": "W"}, {"family": "Serrano-Aroca", "given": "\u00c1ngel", "initials": "\u00c1"}, {"family": "Brufsky", "given": "Adam M", "initials": "AM"}, {"family": "Uhal", "given": "Bruce D", "initials": "BD"}], "type": "journal article", "published": "2020-12-02", "journal": {"title": "FEBS J", "issn": "1742-4658", "volume": null, "issue": null, "issn-l": null}, "abstract": "Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of the pandemic coronavirus disease 2019 (COVID-19) that exhibits an overwhelming contagious capacity over other Human Coronaviruses (HCoVs). This structural snapshot describes the structural bases underlying the pandemic capacity of SARS-CoV-2 and explains its fast motion over respiratory epithelia that allow its rapid cellular entry. Based on notable viral spike (S) protein features, we propose that the flat sialic acid-binding domain at the N-terminal domain (NTD) of the S1 subunit leads to more effective first contact and interaction with the sialic acid layer over the epithelium and this, in turn, allows faster viral \"surfing\" of the epithelium and receptor scanning by SARS-CoV-2. Angiotensin-converting enzyme 2 (ACE-2) protein on the epithelial surface is the primary entry receptor for SARS-CoV-2, and protein-protein interaction assays demonstrate high-affinity binding of the S protein to ACE-2. To date, no high-frequency mutations were detected at the C-terminal domain (CTD) of the S1 subunit in the S protein, where the receptor-binding domain (RBD) is located. Tight binding to ACE-2 by a conserved viral RBD suggests the ACE2-RBD interaction is likely optimal. Moreover, the viral S subunit contains a cleavage site for furin and other proteases, which accelerates cell entry by SARS-CoV-2. The model proposed here describes a structural basis for the accelerated host cell entry by SARS-CoV-2 relative to other HCoVs, and also discusses emerging hypotheses that are likely to contribute to the development of antiviral strategies to combat the pandemic capacity of SARS-CoV-2.", "doi": "10.1111/febs.15651", "pmid": "33264497", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Proteins": null}, "xrefs": [], "notes": [], "created": "2020-12-03T08:14:27.869Z", "modified": "2021-02-26T08:47:18.753Z"}, {"entity": "publication", "iuid": "65b0f9f550b94462a14f0e75bbd3e9ed", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65b0f9f550b94462a14f0e75bbd3e9ed.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65b0f9f550b94462a14f0e75bbd3e9ed"}}, "title": "Lack of evidence of ACE2 expression and replicative infection by SARS-CoV-2 in human endothelial cells", "authors": [{"family": "McCracken", "given": "Ian", "initials": "I"}, {"family": "Saginc", "given": "Gaye", "initials": "G"}, {"family": "He", "given": "Liqun", "initials": "L"}, {"family": "Huseynov", "given": "Alik", "initials": "A"}, {"family": "Daniels", "given": "Alison", "initials": "A"}, {"family": "Fletcher", "given": "Sarah", "initials": "S"}, {"family": "Peghaire", "given": "Claire", "initials": "C"}, {"family": "Kalna", "given": "Viktoria", "initials": "V"}, {"family": "Andaloussi-M\u00e4e", "given": "Maarja", "initials": "M"}, {"family": "Muhl", "given": "Lars", "initials": "L"}, {"family": "Craig", "given": "Nicky M", "initials": "NM"}, {"family": "Griffiths", "given": "Samantha J", "initials": "SJ"}, {"family": "Haas", "given": "J\u00fcrgen G", "initials": "JG"}, {"family": "Tait-Burkard", "given": "Christine", "initials": "C"}, {"family": "Lendahl", "given": "Urban", "initials": "U"}, {"family": "Birdsey", "given": "Graeme M", "initials": "GM"}, {"family": "Betsholtz", "given": "Christer", "initials": "C"}, {"family": "Noseda", "given": "Michela", "initials": "M"}, {"family": "Baker", "given": "Andrew", "initials": "A"}, {"family": "Randi", "given": "Anna M", "initials": "AM"}], "type": "posted-content", "published": "2020-12-02", "journal": {"title": "", "issn": null, "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1101/2020.12.02.391664", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-06-10T04:18:46.697Z", "modified": "2021-06-10T04:19:16.922Z"}, {"entity": "publication", "iuid": "68f8998fb8eb43d1b66b8b9accbeedbb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68f8998fb8eb43d1b66b8b9accbeedbb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68f8998fb8eb43d1b66b8b9accbeedbb"}}, "title": "Dietary supplements during the COVID-19 pandemic: insights from 1.4M users of the COVID Symptom Study app - a longitudinal app-based community survey", "authors": [{"family": "Louca", "given": "Panayiotis", "initials": "P"}, {"family": "Murray", "given": "Benjamin", "initials": "B"}, {"family": "Klaser", "given": "K", "initials": "K"}, {"family": "Graham", "given": "MS", "initials": "M"}, {"family": "Mazidi", "given": "M", "initials": "M"}, {"family": "Leeming", "given": "ER", "initials": "E"}, {"family": "Thompson", "given": "E", "initials": "E"}, {"family": "Bowyer", "given": "R", "initials": "R"}, {"family": "Drew", "given": "DA", "initials": "D"}, {"family": "Nguyen", "given": "LH", "initials": "L"}, {"family": "Merino", "given": "J", "initials": "J"}, {"family": "Gomez", "given": "M", "initials": "M"}, {"family": "Mompeo", "given": "O", "initials": "O"}, {"family": "Costeira", "given": "R", "initials": "R"}, {"family": "Sudre", "given": "CH", "initials": "C"}, {"family": "Gibson", "given": "R", "initials": "R"}, {"family": "Steves", "given": "CJ", "initials": "C"}, {"family": "Wolf", "given": "J V", "initials": "JV"}, {"family": "Franks", "given": "PW", "initials": "P"}, {"family": "Ourselin", "given": "S", "initials": "S"}, {"family": "Chan", "given": "AT", "initials": "A"}, {"family": "Berry", "given": "SE", "initials": "S"}, {"family": "Valdes", "given": "AM", "initials": "A"}, {"family": "Calder", "given": "PC", "initials": "P"}, {"family": "Spector", "given": "TD", "initials": "T"}, {"family": "Menni", "given": "C", "initials": "C"}], "type": "posted-content", "published": "2020-12-02", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.11.27.20239087", "pmid": null, "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-02T07:31:41.833Z", "modified": "2021-03-10T15:20:35.782Z"}, {"entity": "publication", "iuid": "d10da61364bd4d2ba71ac7c1e0001a18", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d10da61364bd4d2ba71ac7c1e0001a18.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d10da61364bd4d2ba71ac7c1e0001a18"}}, "title": "Correction to: Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS.", "authors": [{"family": "Ferrando", "given": "Carlos", "initials": "C"}, {"family": "Suarez-Sipmann", "given": "Fernando", "initials": "F"}, {"family": "Mellado-Artigas", "given": "Ricard", "initials": "R"}, {"family": "Hern\u00e1ndez", "given": "Mar\u00eda", "initials": "M"}, {"family": "Gea", "given": "Alfredo", "initials": "A"}, {"family": "Arruti", "given": "Egoitz", "initials": "E"}, {"family": "Aldecoa", "given": "C\u00e9sar", "initials": "C"}, {"family": "Mart\u00ednez-Pall\u00ed", "given": "Graciela", "initials": "G"}, {"family": "Mart\u00ednez-Gonz\u00e1lez", "given": "Miguel A", "initials": "MA"}, {"family": "Slutsky", "given": "Arthur S", "initials": "AS"}, {"family": "Villar", "given": "Jes\u00fas", "initials": "J"}, {"family": "COVID-19 Spanish ICU Network", "given": "", "initials": ""}], "type": "published erratum", "published": "2020-12-02", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "volume": null, "issue": null, "issn-l": "0342-4642"}, "abstract": "The original version of this article unfortunately contained mistakes in Figures 1 and 3.", "doi": "10.1007/s00134-020-06251-8", "pmid": "33263817", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-020-06251-8"}], "notes": [], "created": "2020-12-03T08:15:09.651Z", "modified": "2020-12-03T15:45:39.142Z"}, {"entity": "publication", "iuid": "c82b76966c9f480594729958632f9b2b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c82b76966c9f480594729958632f9b2b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c82b76966c9f480594729958632f9b2b"}}, "title": "Clinical and molecular practice of European thoracic pathology laboratories during the COVID-19 pandemic. The past and the near future.", "authors": [{"family": "Hofman", "given": "P", "initials": "P"}, {"family": "Ili\u00e9", "given": "M", "initials": "M"}, {"family": "Chamorey", "given": "E", "initials": "E"}, {"family": "Brest", "given": "P", "initials": "P"}, {"family": "Schiappa", "given": "R", "initials": "R"}, {"family": "Nakache", "given": "V", "initials": "V"}, {"family": "Antoine", "given": "M", "initials": "M"}, {"family": "Barberis", "given": "M", "initials": "M"}, {"family": "Begueret", "given": "H", "initials": "H"}, {"family": "Bibeau", "given": "F", "initials": "F"}, {"family": "Bonnetaud", "given": "C", "initials": "C"}, {"family": "Bostr\u00f6m", "given": "P", "initials": "P"}, {"family": "Brousset", "given": "P", "initials": "P"}, {"family": "Bubendorf", "given": "L", "initials": "L"}, {"family": "Carvalho", "given": "L", "initials": "L"}, {"family": "Cathomas", "given": "G", "initials": "G"}, {"family": "Cazes", "given": "A", "initials": "A"}, {"family": "Chalabreysse", "given": "L", "initials": "L"}, {"family": "Chenard", "given": "M-P", "initials": "MP"}, {"family": "Copin", "given": "M-C", "initials": "MC"}, {"family": "C\u00f4t\u00e9", "given": "J-F", "initials": "JF"}, {"family": "Damotte", "given": "D", "initials": "D"}, {"family": "de Leval", "given": "L", "initials": "L"}, {"family": "Delongova", "given": "P", "initials": "P"}, {"family": "Thomas de Montpreville", "given": "V", "initials": "V"}, {"family": "de Muret", "given": "A", "initials": "A"}, {"family": "Dema", "given": "A", "initials": "A"}, {"family": "Dietmaier", "given": "W", "initials": "W"}, {"family": "Evert", "given": "M", "initials": "M"}, {"family": "Fabre", "given": "A", "initials": "A"}, {"family": "Forest", "given": "F", "initials": "F"}, {"family": "Foulet", "given": "A", "initials": "A"}, {"family": "Garcia", "given": "S", "initials": "S"}, {"family": "Garcia-Martos", "given": "M", "initials": "M"}, {"family": "Gibault", "given": "L", "initials": "L"}, {"family": "Gorkiewicz", "given": "G", "initials": "G"}, {"family": "Jonigk", "given": "D", "initials": "D"}, {"family": "Gosney", "given": "J", "initials": "J"}, {"family": "Hofman", "given": "A", "initials": "A"}, {"family": "Kern", "given": "I", "initials": "I"}, {"family": "Kerr", "given": "K", "initials": "K"}, {"family": "Kossai", "given": "M", "initials": "M"}, {"family": "Kriegsmann", "given": "M", "initials": "M"}, {"family": "Lassalle", "given": "S", "initials": "S"}, {"family": "Long-Mira", "given": "E", "initials": "E"}, {"family": "Lupo", "given": "A", "initials": "A"}, {"family": "Mamilos", "given": "A", "initials": "A"}, {"family": "Mat\u011bj", "given": "R", "initials": "R"}, {"family": "Meilleroux", "given": "J", "initials": "J"}, {"family": "Ortiz-Villal\u00f3n", "given": "C", "initials": "C"}, {"family": "Panico", "given": "L", "initials": "L"}, {"family": "Panizo", "given": "A", "initials": "A"}, {"family": "Papotti", "given": "M", "initials": "M"}, {"family": "Pauwels", "given": "P", "initials": "P"}, {"family": "Pelosi", "given": "G", "initials": "G"}, {"family": "Penault-Llorca", "given": "F", "initials": "F"}, {"family": "Pop", "given": "O", "initials": "O"}, {"family": "Pot\u00e9", "given": "N", "initials": "N"}, {"family": "Cajal", "given": "S R Y", "initials": "SRY"}, {"family": "Sabourin", "given": "J-C", "initials": "JC"}, {"family": "Salmon", "given": "I", "initials": "I"}, {"family": "Sajin", "given": "M", "initials": "M"}, {"family": "Savic-Prince", "given": "S", "initials": "S"}, {"family": "Schildhaus", "given": "H-U", "initials": "HU"}, {"family": "Schirmacher", "given": "P", "initials": "P"}, {"family": "Serre", "given": "I", "initials": "I"}, {"family": "Shaw", "given": "E", "initials": "E"}, {"family": "Sizaret", "given": "D", "initials": "D"}, {"family": "Stenzinger", "given": "A", "initials": "A"}, {"family": "Stojsic", "given": "J", "initials": "J"}, {"family": "Thunnissen", "given": "E", "initials": "E"}, {"family": "Timens", "given": "W", "initials": "W"}, {"family": "Troncone", "given": "G", "initials": "G"}, {"family": "Werlein", "given": "C", "initials": "C"}, {"family": "Wolff", "given": "H", "initials": "H"}, {"family": "Berthet", "given": "J-P", "initials": "JP"}, {"family": "Benzaquen", "given": "J", "initials": "J"}, {"family": "Marquette", "given": "C-H", "initials": "CH"}, {"family": "Hofman", "given": "V", "initials": "V"}, {"family": "Calabrese", "given": "F", "initials": "F"}], "type": "journal article", "published": "2020-12-02", "journal": {"title": "ESMO Open", "issn": "2059-7029", "volume": "6", "issue": "1", "pages": "100024", "issn-l": null}, "abstract": "This study evaluated the consequences in Europe of the COVID-19 outbreak on pathology laboratories orientated toward the diagnosis of thoracic diseases.\n\nA survey was sent to 71 pathology laboratories from 21 European countries. The questionnaire requested information concerning the organization of biosafety, the clinical and molecular pathology, the biobanking, the workload, the associated research into COVID-19, and the organization of education and training during the COVID-19 crisis, from 15 March to 31 May 2020, compared with the same period in 2019.\n\nQuestionnaires were returned from 53/71 (75%) laboratories from 18 European countries. The biosafety procedures were heterogeneous. The workload in clinical and molecular pathology decreased dramatically by 31% (range, 3%-55%) and 26% (range, 7%-62%), respectively. According to the professional category, between 28% and 41% of the staff members were not present in the laboratories but did teleworking. A total of 70% of the laboratories developed virtual meetings for the training of residents and junior pathologists. During the period of study, none of the staff members with confirmed COVID-19 became infected as a result of handling samples.\n\nThe COVID-19 pandemic has had a strong impact on most of the European pathology laboratories included in this study. Urgent implementation of several changes to the organization of most of these laboratories, notably to better harmonize biosafety procedures, was noted at the onset of the pandemic and maintained in the event of a new wave of infection occurring in Europe.", "doi": "10.1016/j.esmoop.2020.100024", "pmid": "33399086", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2021-01-07T09:59:21.979Z", "modified": "2021-02-26T08:45:48.695Z"}, {"entity": "publication", "iuid": "baaedfcf6bed471ba1aff4e643a673f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/baaedfcf6bed471ba1aff4e643a673f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/baaedfcf6bed471ba1aff4e643a673f0"}}, "title": "The association of mode of location activity and mobility with acute coronary syndrome: nationwide ecological study.", "authors": [{"family": "Mohammad", "given": "Moman A", "initials": "MA"}, {"family": "Koul", "given": "Sasha", "initials": "S"}, {"family": "Gale", "given": "Chris P", "initials": "CP"}, {"family": "Alfredsson", "given": "Joakim", "initials": "J"}, {"family": "James", "given": "Stefan", "initials": "S"}, {"family": "Fr\u00f6bert", "given": "Ole", "initials": "O"}, {"family": "Omerovic", "given": "Elmir", "initials": "E"}, {"family": "Erlinge", "given": "David", "initials": "D"}], "type": "journal article", "published": "2020-12-01", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "We aimed to study the effect of social containment mandates on ACS presentation during COVID-19 pandemic using location activity and mobility data from mobile phone map services.\r\n\r\nWe conducted a cross-sectional study using data from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) including all ACS presentations during the pandemic until May 07, 2020. Using a count regression model, we adjusted for day of the week, daily weather, and incidence of COVID-19.\r\n\r\nA 10% increase in activity around areas of residence was associated with 38% lower rates of ACS hospitalisations whereas increased activity relating to retail and recreation, grocery stores and pharmacies, workplaces as well as mode of mobility was associated with 10-20% higher rates of ACS hospitalisations.\r\n\r\nGovernment policy regarding social containment mandates has important public health implications for medical emergencies like ACS and may explain the decline in ACS presentations observed during COVID-19 pandemic.", "doi": "10.1111/joim.13206", "pmid": "33259680", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-12-03T08:16:01.869Z", "modified": "2021-02-26T08:47:00.178Z"}, {"entity": "publication", "iuid": "3e2f34a3e6064d69af05e77761d57bc9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3e2f34a3e6064d69af05e77761d57bc9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3e2f34a3e6064d69af05e77761d57bc9"}}, "title": "Nowcasting the COVID-19 pandemic in Bavaria.", "authors": [{"family": "G\u00fcnther", "given": "Felix", "initials": "F"}, {"family": "Bender", "given": "Andreas", "initials": "A"}, {"family": "Katz", "given": "Katharina", "initials": "K"}, {"family": "K\u00fcchenhoff", "given": "Helmut", "initials": "H"}, {"family": "H\u00f6hle", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2020-12-01", "journal": {"title": "Biom J", "issn": "1521-4036", "volume": null, "issue": null, "issn-l": null}, "abstract": "To assess the current dynamics of an epidemic, it is central to collect information on the daily number of newly diseased cases. This is especially important in real-time surveillance, where the aim is to gain situational awareness, for example, if cases are currently increasing or decreasing. Reporting delays between disease onset and case reporting hamper our ability to understand the dynamics of an epidemic close to now when looking at the number of daily reported cases only. Nowcasting can be used to adjust daily case counts for occurred-but-not-yet-reported events. Here, we present a novel application of nowcasting to data on the current COVID-19 pandemic in Bavaria. It is based on a hierarchical Bayesian model that considers changes in the reporting delay distribution over time and associated with the weekday of reporting. Furthermore, we present a way to estimate the effective time-varying case reproduction number based on predictions of the nowcast. The approaches are based on previously published work, that we considerably extended and adapted to the current task of nowcasting COVID-19 cases. We provide methodological details of the developed approach, illustrate results based on data of the current pandemic, and evaluate the model based on synthetic and retrospective data on COVID-19 in Bavaria. Results of our nowcasting are reported to the Bavarian health authority and published on a webpage on a daily basis (https://corona.stat.uni-muenchen.de/). Code and synthetic data for the analysis are available from https://github.com/FelixGuenther/nc_covid19_bavaria and can be used for adaption of our approach to different data. R e ( t )", "doi": "10.1002/bimj.202000112", "pmid": "33258177", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-03T08:17:03.493Z", "modified": "2021-02-26T08:46:13.061Z"}, {"entity": "publication", "iuid": "4c2735cd7177484b885331b93bacba85", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4c2735cd7177484b885331b93bacba85.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4c2735cd7177484b885331b93bacba85"}}, "title": "Modeling of the adsorption of a protein-fragment on kaolinite with potential antiviral activity.", "authors": [{"family": "Awad", "given": "Mahmoud E", "initials": "ME"}, {"family": "Borrego-S\u00e1nchez", "given": "Ana", "initials": "A"}, {"family": "Escamilla-Roa", "given": "Elizabeth", "initials": "E"}, {"family": "Hern\u00e1ndez-Laguna", "given": "Alfonso", "initials": "A"}, {"family": "Sainz-D\u00edaz", "given": "C Ignacio", "initials": "CI"}], "type": "journal article", "published": "2020-12-01", "journal": {"title": "Appl Clay Sci", "issn": "0169-1317", "issn-l": null, "volume": "199", "issue": null, "pages": "105865"}, "abstract": "This work aimed at studying the potentiality of interactions between kaolinite surfaces and a protein-fragment (350-370 amino acid units) extracted from the glycoprotein E1 in the transmembrane domain (TMD) of hepatitis C virus capsid. A computational work was performed for locating the potential electrostatic interaction sites between kaolinite aluminol and siloxane surfaces and the residues of this protein-fragment ligand, monitoring the possible conformational changes. This hydrated neutralized kaolinite/protein-fragment system was simulated by means of molecular modeling based on atomistic force fields based on empirical interatomic potentials and molecular dynamic (MD) simulations. The MD calculations indicated that the studied protein-fragment interacted with the kaolinite surfaces with an exothermic process and structural distortions were observed, particularly with the hydrophilic aluminol surface by favorable adsorption energy. The viral units isolation or trapping by the adsorption on the kaolinite nanoparticles producing structural distortion of the peptide ligands could lead to the blockage of the entry on the receptor and hence a lack of viral activity would be produced. Therefore, these findings with the proposed insights could be an useful information for the next experimental and development studies in the area of discovering inhibitors of the global challenged hepatitis and other pathogenic viruses based on the phyllosilicate surface activity. These MD studies can be extended to other viruses like the COVID-19 interacting with silicate minerals surfaces.", "doi": "10.1016/j.clay.2020.105865", "pmid": "33078035", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S0169-1317(20)30430-0"}, {"db": "pmc", "key": "PMC7556793"}], "notes": [], "created": "2020-12-01T16:57:41.658Z", "modified": "2021-02-26T08:45:25.864Z"}, {"entity": "publication", "iuid": "447cc7afc9f745eba4a64bd311f4a71e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/447cc7afc9f745eba4a64bd311f4a71e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/447cc7afc9f745eba4a64bd311f4a71e"}}, "title": "Impact of SARS-CoV-2 Pandemic on Patients with Primary Immunodeficiency.", "authors": [{"family": "Delavari", "given": "Samaneh", "initials": "S"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Abolnezhadian", "given": "Farhad", "initials": "F"}, {"family": "Babaha", "given": "Fateme", "initials": "F"}, {"family": "Iranparast", "given": "Sara", "initials": "S"}, {"family": "Ahanchian", "given": "Hamid", "initials": "H"}, {"family": "Moazzen", "given": "Nasrin", "initials": "N"}, {"family": "Nabavi", "given": "Mohammad", "initials": "M"}, {"family": "Arshi", "given": "Saba", "initials": "S"}, {"family": "Fallahpour", "given": "Morteza", "initials": "M"}, {"family": "Bemanian", "given": "Mohammad Hassan", "initials": "MH"}, {"family": "Shokri", "given": "Sima", "initials": "S"}, {"family": "Momen", "given": "Tooba", "initials": "T"}, {"family": "Sadeghi-Shabestari", "given": "Mahnaz", "initials": "M"}, {"family": "Molatefi", "given": "Rasol", "initials": "R"}, {"family": "Shirkani", "given": "Afshin", "initials": "A"}, {"family": "Vosughimotlagh", "given": "Ahmad", "initials": "A"}, {"family": "Safarirad", "given": "Molood", "initials": "M"}, {"family": "Sharifzadeh", "given": "Meisam", "initials": "M"}, {"family": "Pashangzadeh", "given": "Salar", "initials": "S"}, {"family": "Salami", "given": "Fereshte", "initials": "F"}, {"family": "Shirmast", "given": "Paniz", "initials": "P"}, {"family": "Rezaei", "given": "Arezou", "initials": "A"}, {"family": "Moeini Shad", "given": "Tannaz", "initials": "T"}, {"family": "Mohraz", "given": "Minoo", "initials": "M"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}, {"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Yazdani", "given": "Reza", "initials": "R"}, {"family": "Aghamohamamdi", "given": "Asghar", "initials": "A"}], "type": "journal article", "published": "2020-12-01", "journal": {"title": "J Clin Immunol", "issn": "1573-2592", "issn-l": "0271-9142", "volume": null, "issue": null, "pages": null}, "abstract": "Although it is estimated that COVID-19 life-threatening conditions may be diagnosed in less than 1:1000 infected individuals below the age of 50, but the real impact of this pandemic on pediatric patients with different types of primary immunodeficiency (PID) is not elucidated. The current prospective study on a national registry of PID patients showed that with only 1.23 folds higher incidence of infections, these patients present a 10-folds higher mortality rate compared to population mainly in patients with combined immunodeficiency and immune dysregulation. Therefore, further management modalities against COVID-19 should be considered to improve the survival rate in these two PID entities using hematopoietic stem cell transplantation and immunomodulatory agents.", "doi": "10.1007/s10875-020-00928-x", "pmid": "33263173", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10875-020-00928-x"}, {"db": "URL", "key": "https://static-content.springer.com/esm/art%3A10.1007%2Fs10875-020-00928-x/MediaObjects/10875_2020_928_MOESM1_ESM.docx", "description": "General laboratory tests, immunologic investigation, computed tomographies of the chest of 17 primary immunodeficient patients infected with COVID-19"}], "notes": [], "created": "2020-12-03T15:43:43.540Z", "modified": "2021-02-26T08:46:59.930Z"}, {"entity": "publication", "iuid": "7c56f4ea33f149498351b25ed3576255", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7c56f4ea33f149498351b25ed3576255.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7c56f4ea33f149498351b25ed3576255"}}, "title": "Guidelines for accurate genotyping of SARS-CoV-2 using amplicon-based sequencing of clinical samples", "authors": [{"family": "Kubik", "given": "Slawomir", "initials": "S"}, {"family": "Marques", "given": "Ana Claudia", "initials": "AC"}, {"family": "Xing", "given": "Xiaobin", "initials": "X"}, {"family": "Silvery", "given": "Janine", "initials": "J"}, {"family": "Bertelli", "given": "Claire", "initials": "C"}, {"family": "De Maio", "given": "Flavio", "initials": "F"}, {"family": "Pournaras", "given": "Spyros", "initials": "S"}, {"family": "Burr", "given": "Tom", "initials": "T"}, {"family": "Duffourd", "given": "Yannis", "initials": "Y"}, {"family": "Siemens", "given": "Helena", "initials": "H"}, {"family": "Alloui", "given": "Chakib", "initials": "C"}, {"family": "Song", "given": "Lin", "initials": "L"}, {"family": "Wenger", "given": "Yvan", "initials": "Y"}, {"family": "Saitta", "given": "Alexandra", "initials": "A"}, {"family": "Macheret", "given": "Morgane", "initials": "M"}, {"family": "Smith", "given": "Ewan W", "initials": "EW"}, {"family": "Menu", "given": "Philippe", "initials": "P"}, {"family": "Brayer", "given": "Marion", "initials": "M"}, {"family": "Steinmetz", "given": "Lars M", "initials": "LM"}, {"family": "Si-Mohammed", "given": "Ali", "initials": "A"}, {"family": "Chuisseu", "given": "Josiane", "initials": "J"}, {"family": "Stevens", "given": "Richard", "initials": "R"}, {"family": "Constantoulakis", "given": "Pantelis", "initials": "P"}, {"family": "Sali", "given": "Michela", "initials": "M"}, {"family": "Greub", "given": "Gilbert", "initials": "G"}, {"family": "Tiemann", "given": "Carsten", "initials": "C"}, {"family": "Pelechano", "given": "Vicent", "initials": "V"}, {"family": "Willig", "given": "Adrian", "initials": "A"}, {"family": "Xu", "given": "Zhenyu", "initials": "Z"}], "type": "posted-content", "published": "2020-12-01", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.12.01.405738", "pmid": null, "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2021-01-20T06:32:09.512Z", "modified": "2021-02-26T08:46:13.311Z"}, {"entity": "publication", "iuid": "477c635341c54c83bea977ad9798e940", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/477c635341c54c83bea977ad9798e940.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/477c635341c54c83bea977ad9798e940"}}, "title": "Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science.", "authors": [{"family": "Evans", "given": "Paul C", "initials": "PC"}, {"family": "Rainger", "given": "G Ed", "initials": "GE"}, {"family": "Mason", "given": "Justin C", "initials": "JC"}, {"family": "Guzik", "given": "Tomasz J", "initials": "TJ"}, {"family": "Osto", "given": "Elena", "initials": "E"}, {"family": "Stamataki", "given": "Zania", "initials": "Z"}, {"family": "Neil", "given": "Desley", "initials": "D"}, {"family": "Hoefer", "given": "Imo E", "initials": "IE"}, {"family": "Fragiadaki", "given": "Maria", "initials": "M"}, {"family": "Waltenberger", "given": "Johannes", "initials": "J"}, {"family": "Weber", "given": "Christian", "initials": "C"}, {"family": "Bochaton-Piallat", "given": "Marie-Luce", "initials": "ML"}, {"family": "B\u00e4ck", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2020-12-01", "journal": {"title": "Cardiovasc Res", "issn": "1755-3245", "volume": "116", "issue": "14", "pages": "2177-2184", "issn-l": null}, "abstract": "The COVID-19 pandemic is an unprecedented healthcare emergency causing mortality and illness across the world. Although primarily affecting the lungs, the SARS-CoV-2 virus also affects the cardiovascular system. In addition to cardiac effects, e.g. myocarditis, arrhythmias, and myocardial damage, the vasculature is affected in COVID-19, both directly by the SARS-CoV-2 virus, and indirectly as a result of a systemic inflammatory cytokine storm. This includes the role of the vascular endothelium in the recruitment of inflammatory leucocytes where they contribute to tissue damage and cytokine release, which are key drivers of acute respiratory distress syndrome (ARDS), in disseminated intravascular coagulation, and cardiovascular complications in COVID-19. There is also evidence linking endothelial cells (ECs) to SARS-CoV-2 infection including: (i) the expression and function of its receptor angiotensin-converting enzyme 2 (ACE2) in the vasculature; (ii) the prevalence of a Kawasaki disease-like syndrome (vasculitis) in COVID-19; and (iii) evidence of EC infection with SARS-CoV-2 in patients with fatal COVID-19. Here, the Working Group on Atherosclerosis and Vascular Biology together with the Council of Basic Cardiovascular Science of the European Society of Cardiology provide a Position Statement on the importance of the endothelium in the underlying pathophysiology behind the clinical presentation in COVID-19 and identify key questions for future research to address. We propose that endothelial biomarkers and tests of function (e.g. flow-mediated dilatation) should be evaluated for their usefulness in the risk stratification of COVID-19 patients. A better understanding of the effects of SARS-CoV-2 on endothelial biology in both the micro- and macrovasculature is required, and endothelial function testing should be considered in the follow-up of convalescent COVID-19 patients for early detection of long-term cardiovascular complications.", "doi": "10.1093/cvr/cvaa230", "pmid": "32750108", "labels": {"Type: Review": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7454368"}, {"db": "pii", "key": "5880580"}], "notes": [], "created": "2020-12-07T15:56:02.856Z", "modified": "2023-07-13T11:29:37.533Z"}, {"entity": "publication", "iuid": "a087f8d635b14ca6b9b1369168d27799", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a087f8d635b14ca6b9b1369168d27799.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a087f8d635b14ca6b9b1369168d27799"}}, "title": "Direct oral anticoagulant use and risk of severe COVID-19.", "authors": [{"family": "Flam", "given": "Benjamin", "initials": "B"}, {"family": "Wintzell", "given": "Viktor", "initials": "V"}, {"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}, {"family": "Pasternak", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2020-12-01", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Hypercoagulability and thromboembolism are prominent features of severe COVID-19, and ongoing anticoagulant use might be protective.\r\n\r\nWe conducted a nationwide register-based cohort study in Sweden, February through May, 2020, to assess whether ongoing direct oral anticoagulant (DOAC) use was associated with reduced risk of hospital admission for laboratory-confirmed COVID-19, or a composite of intensive care unit (ICU) admission or death due to laboratory-confirmed COVID-19.\r\n\r\nDOAC use (n=103 703) was not associated with reduced risk of hospital admission for COVID-19 (adjusted hazard ratio [aHR] [95% confidence interval] 1.00 [0.75-1.33] vs. non-use atrial fibrillation comparator [n=36 875]; and aHR 0.94 [0.80-1.10] vs. non-use cardiovascular disease comparator [n=355 699]), or ICU admission or death due to COVID-19 (aHRs 0.76 [0.51-1.12], and 0.90 [0.71-1.15], respectively).\r\n\r\nOngoing DOAC use was not associated with reduced risk of severe COVID-19, indicating that prognosis would not be modified by early outpatient DOAC initiation.", "doi": "10.1111/joim.13205", "pmid": "33258156", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-03T08:17:34.751Z", "modified": "2021-02-26T08:45:48.532Z"}, {"entity": "publication", "iuid": "00ef148f8d674870a00321fd8e20f2a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/00ef148f8d674870a00321fd8e20f2a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/00ef148f8d674870a00321fd8e20f2a4"}}, "title": "Who safeguards pregnant women's autonomy during the COVID-19 pandemic?", "authors": [{"family": "Linden", "given": "Karolina", "initials": "K"}, {"family": "Maimburg", "given": "Rikke Damkj\u00e6r", "initials": "RD"}], "type": "editorial", "published": "2020-12-00", "journal": {"title": "Sex Reprod Healthc", "issn": "1877-5764", "volume": "26", "issue": null, "pages": "100556", "issn-l": null}, "abstract": null, "doi": "10.1016/j.srhc.2020.100556", "pmid": "33010666", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S1877-5756(20)30194-4"}, {"db": "pmc", "key": "PMC7513889"}], "notes": [], "created": "2020-12-03T08:53:50.819Z", "modified": "2020-12-03T08:53:50.842Z"}, {"entity": "publication", "iuid": "261224bff6264269933daf9333f0b375", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/261224bff6264269933daf9333f0b375.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/261224bff6264269933daf9333f0b375"}}, "title": "Transitioning from face-to-face treatment to iCBT for youths in primary care - therapists' attitudes and experiences.", "authors": [{"family": "Weineland", "given": "Sandra", "initials": "S"}, {"family": "Ribbeg\u00e5rdh", "given": "Rasmus", "initials": "R"}, {"family": "Kivi", "given": "Marie", "initials": "M"}, {"family": "Bygdell", "given": "Andreas", "initials": "A"}, {"family": "Larsson", "given": "Anna", "initials": "A"}, {"family": "Vernmark", "given": "Kristofer", "initials": "K"}, {"family": "Lilja", "given": "Josefine L", "initials": "JL"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Internet Interv", "issn": "2214-7829", "volume": "22", "issue": null, "pages": "100356", "issn-l": "2214-7829"}, "abstract": "To address the increasing mental health problems among young people, health care needs to broaden the spectrum of interventions and increase access to care. One particularly promising first-line intervention is cognitive behavioral therapy (CBT) delivered via the Internet (iCBT). The outbreak of the Coronavirus disease -2019 (COVID -19) has made the need for solid digital mental health care systems clear. This is the first published study exploring the transition among therapists of working with face-to-face treatment to using iCBT for youths suffering from anxiety treated in primary care.\n\nFourteen primary care therapists were included in the study. Semi-structured interviews (n = 26) were conducted on two occasions: before starting to use iCBT for youths, and at a subsequent follow-up after gaining treatment experience. Data was summarized into thematic categories.\n\nThe overarching themes that were identified were: Attitudes to iCBT before and after implementation; Experiences of treatment delivery; Characteristics of \"the right patient;\" and The role of the digital therapist.\n\nThe participants generally had positive attitudes to iCBT for youths and saw it as a valuable alternative to face-to-face treatments. However, they identified challenges related to patient selection, and to motivating patients and maintaining a therapeutic relationship through mainly written communication. The participants appreciated the increase in variety that iCBT brought to their schedules, and also experienced iCBT as a relief from common challenges of therapeutic work, such as emotional stress and high cognitive demands. The participating therapists' positive experiences support the introduction of iCBT for youths in routine primary care.", "doi": "10.1016/j.invent.2020.100356", "pmid": "33318951", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2214-7829(20)30122-6"}, {"db": "pmc", "key": "PMC7724368"}], "notes": [], "created": "2020-12-21T10:10:30.198Z", "modified": "2021-02-26T08:46:59.868Z"}, {"entity": "publication", "iuid": "e15a41ecb1524431b4580ca26555b4fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e15a41ecb1524431b4580ca26555b4fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e15a41ecb1524431b4580ca26555b4fa"}}, "title": "Thromboembolism, Hypercoagulopathy, and Antiphospholipid Antibodies in Critically Ill Coronavirus Disease 2019 Patients: A Before and After Study of Enhanced Anticoagulation", "authors": [{"family": "van der Linden", "given": "Jan", "initials": "J"}, {"family": "Almskog", "given": "Lou", "initials": "L"}, {"family": "Liliequist", "given": "Andreas", "initials": "A"}, {"family": "Grip", "given": "Jonathan", "initials": "J"}, {"family": "Fux", "given": "Thomas", "initials": "T"}, {"family": "Rysz", "given": "Susanne", "initials": "S"}, {"family": "\u00c5gren", "given": "Anna", "initials": "A"}, {"family": "Oldner", "given": "Anders", "initials": "A"}, {"family": "St\u00e5hlberg", "given": "Marcus", "initials": "M"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "Crit Care Explorations", "issn": "2639-8028", "issn-l": null, "volume": "2", "issue": "12", "pages": "e0308"}, "abstract": null, "doi": "10.1097/cce.0000000000000308", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-08T09:33:38.702Z", "modified": "2021-02-26T08:45:48.796Z"}, {"entity": "publication", "iuid": "224a7ae30efa43aa81366a5ea538dbcd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/224a7ae30efa43aa81366a5ea538dbcd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/224a7ae30efa43aa81366a5ea538dbcd"}}, "title": "The first eight months of Sweden's COVID-19 strategy and the key actions and actors that were involved.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF", "orcid": "0000-0003-1024-5602", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e1d5e45881a7469ca20a0eb360d891cc.json"}}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": "109", "issue": "12", "pages": "2459-2471", "issn-l": "0803-5253"}, "abstract": "COVID-19 has affected millions of people worldwide. This paper reviews the Swedish pandemic response.\n\nA narrative review was carried out and a timeline constructed.\n\nBy September 1, 2020, 0.8% of Swedish residents had tested positive for the virus and 0.06% of the population had died, which was higher than neighbouring Nordic countries, but lower than some European countries with general lockdowns. The main actors were the Public Health Agency, the National Board of Health and Welfare, the Civil Contingencies Agency and the Government. County councils and regions implemented policies, in conjunction with the Department of Education and county administrative boards. Sweden's response was less invasive than many other countries, with no general lockdown. It focused on mitigation: slowing, but not stopping, the pandemic. Physical distancing was recommended in public spaces, but mandatory in bars, restaurants and at events. Visits to nursing facilities were banned. Kindergartens and schools for children up to 16 stayed open, but closed for older children for three months. There were no enforced quarantines for infected households or geographical regions, and facemasks were not recommended outside health care.\n\nSweden chose a different pandemic strategy to its peer nations. This paper examines the first eight months.", "doi": "10.1111/apa.15582", "pmid": "32951258", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7537539"}], "notes": [], "created": "2020-11-26T12:26:45.047Z", "modified": "2023-01-13T13:29:39.327Z"}, {"entity": "publication", "iuid": "3694aab447f0437394fb108e7234d197", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3694aab447f0437394fb108e7234d197.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3694aab447f0437394fb108e7234d197"}}, "title": "The effect of interventions on COVID-19.", "authors": [{"family": "Soltesz", "given": "Kristian", "initials": "K", "orcid": "0000-0001-6378-7646", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/936add4190154f9a8642f999147592e2.json"}}, {"family": "Gustafsson", "given": "Fredrik", "initials": "F"}, {"family": "Timpka", "given": "Toomas", "initials": "T"}, {"family": "Jald\u00e9n", "given": "Joakim", "initials": "J"}, {"family": "Jidling", "given": "Carl", "initials": "C"}, {"family": "Heimerson", "given": "Albin", "initials": "A"}, {"family": "Sch\u00f6n", "given": "Thomas B", "initials": "TB", "orcid": "0000-0001-5183-234X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/749950fca61f4c5b8801f4f22928594f.json"}}, {"family": "Spreco", "given": "Armin", "initials": "A", "orcid": "0000-0003-0985-8209", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29a7cab23d784f898e1706bb138caa0f.json"}}, {"family": "Ekberg", "given": "Joakim", "initials": "J"}, {"family": "Dahlstr\u00f6m", "given": "\u00d6rjan", "initials": "\u00d6"}, {"family": "Bagge Carlson", "given": "Fredrik", "initials": "F"}, {"family": "J\u00f6ud", "given": "Anna", "initials": "A"}, {"family": "Bernhardsson", "given": "Bo", "initials": "B"}], "type": "letter", "published": "2020-12-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "588", "issue": "7839", "pages": "E26-E28", "issn-l": "0028-0836"}, "abstract": null, "doi": "10.1038/s41586-020-3025-y", "pmid": "33361787", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41586-020-3025-y"}], "notes": [], "created": "2021-01-07T13:41:51.776Z", "modified": "2023-06-19T14:58:31.467Z"}, {"entity": "publication", "iuid": "7b92975b1b11441f935557260a1414e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b92975b1b11441f935557260a1414e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b92975b1b11441f935557260a1414e1"}}, "title": "Swedish policy analysis for Covid-19.", "authors": [{"family": "Kavaliunas", "given": "Andrius", "initials": "A"}, {"family": "Ocaya", "given": "Pauline", "initials": "P"}, {"family": "Mumper", "given": "Jim", "initials": "J"}, {"family": "Lindfeldt", "given": "Isis", "initials": "I"}, {"family": "Kyhlstedt", "given": "Mattias", "initials": "M"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Health Policy Technol", "issn": "2211-8837", "volume": "9", "issue": "4", "pages": "598-612", "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has challenged health care systems and put societies to the test in the world beyond expectations.\n\nOur aim is to describe and analyze the Swedish approach in combating the pandemic.\n\nWe present and discuss data collated from various sources - published scientific studies, pre-print material, agency reports, media communication, public surveys, etc. - with specific focus on the approach itself, Covid-19 trends, healthcare system response, policy and measures overview, and implications.\n\nThe main intervention to manage the curve has been the general recommendations to adhere to good hand hygiene, beware of physical distance to others, to refrain from large gatherings and restrain from non-essential travel. Persons with suspected Covid-19 infection were recommended to stay at home and avoid social contacts. Additionally, visits to the elderly care homes and meetings with more than 50 people were forbidden. As a result, the healthcare system in the country has so far, never been overwhelmed. However, the relatively high mortality among the elderly, together with the vulnerability of some migrants, points out the drawbacks.\n\nMany countries have both marvelled and criticized the Swedish strategy that is formed in a close partnership between the government and the society based on a mutual trust giving the responsibility to individuals. It already highlights how much can be achieved with voluntary measures (recommendations) - something that was noticed and proposed as a future model by the World Health Organization.", "doi": "10.1016/j.hlpt.2020.08.009", "pmid": "32904437", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S2211-8837(20)30081-2"}, {"db": "pmc", "key": "PMC7455549"}], "notes": [], "created": "2020-12-03T16:15:28.228Z", "modified": "2021-02-26T08:46:13.289Z"}, {"entity": "publication", "iuid": "e5040817d84e42569eeb6b0d5b2509f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e5040817d84e42569eeb6b0d5b2509f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e5040817d84e42569eeb6b0d5b2509f8"}}, "title": "Simple technology for COVID-19 medical solid waste treatment in low-resourced settings.", "authors": [{"family": "Bellizzi", "given": "Saverio", "initials": "S"}, {"family": "Kamal", "given": "Sherif A", "initials": "SA"}, {"family": "Newir", "given": "Ahmed E", "initials": "AE"}, {"family": "Pichierri", "given": "Giuseppe", "initials": "G"}, {"family": "Salaris", "given": "Paola", "initials": "P"}, {"family": "Pinto", "given": "Sergio", "initials": "S"}, {"family": "Farina", "given": "Gabriele", "initials": "G"}, {"family": "Fiamma", "given": "Maura", "initials": "M"}, {"family": "Maher", "given": "Osama Ali", "initials": "OA"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Glob Health", "issn": "2047-2986", "issn-l": "2047-2978", "volume": "10", "issue": "2", "pages": "020373"}, "abstract": null, "doi": "10.7189/jogh.10.020373", "pmid": "33282215", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jogh-10-020373"}, {"db": "pmc", "key": "PMC7688062"}], "notes": [], "created": "2020-12-10T09:17:40.665Z", "modified": "2020-12-10T09:18:26.221Z"}, {"entity": "publication", "iuid": "7a458bc696174cd6892145beb010c9c6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a458bc696174cd6892145beb010c9c6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a458bc696174cd6892145beb010c9c6"}}, "title": "Renin\u2013angiotensin system blockers and susceptibility to COVID-19: an international, open science, cohort analysis", "authors": [{"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Conover", "given": "Mitchell M", "initials": "MM"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Pratt", "given": "Nicole", "initials": "N"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "Fern\u00e1ndez-Bertol\u00edn", "given": "Sergio", "initials": "S"}, {"family": "Arag\u00f3n", "given": "Maria", "initials": "M"}, {"family": "DuVall", "given": "Scott L", "initials": "SL"}, {"family": "Lynch", "given": "Kristine", "initials": "K"}, {"family": "Falconer", "given": "Thomas", "initials": "T"}, {"family": "van Bochove", "given": "Kees", "initials": "K"}, {"family": "Sung", "given": "Cynthia", "initials": "C"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Lambert", "given": "Christophe G", "initials": "CG"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Williams", "given": "Andrew E", "initials": "AE"}, {"family": "Park", "given": "Rae Woong", "initials": "RW"}, {"family": "Weaver", "given": "James", "initials": "J"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Schuemie", "given": "Martijn J", "initials": "MJ"}, {"family": "Rijnbeek", "given": "Peter R", "initials": "PR"}, {"family": "Williams", "given": "Ross D", "initials": "RD"}, {"family": "Lane", "given": "Jennifer C E", "initials": "JCE"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Krumholz", "given": "Harlan M", "initials": "HM"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Ryan", "given": "Patrick B", "initials": "PB"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "The Lancet Digital Health", "issn": "2589-7500", "issn-l": null, "volume": "3", "issue": "2", "pages": "e98-e114"}, "abstract": null, "doi": "10.1016/s2589-7500(20)30289-2", "pmid": null, "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://data.ohdsi.org/IcariusSusceptibility/", "description": "Data aggregated by data source"}], "notes": [], "created": "2021-01-10T18:07:44.284Z", "modified": "2021-04-26T18:00:54.936Z"}, {"entity": "publication", "iuid": "e3fd6fbf88d1478283f699293b003c91", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3fd6fbf88d1478283f699293b003c91.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3fd6fbf88d1478283f699293b003c91"}}, "title": "Real-World Issues and Potential Solutions in Hematopoietic Cell Transplantation during the COVID-19 Pandemic: Perspectives from the Worldwide Network for Blood and Marrow Transplantation and Center for International Blood and Marrow Transplant Research Health Services and International Studies Committee.", "authors": [{"family": "Algwaiz", "given": "Ghada", "initials": "G"}, {"family": "Aljurf", "given": "Mahmoud", "initials": "M"}, {"family": "Koh", "given": "Mickey", "initials": "M"}, {"family": "Horowitz", "given": "Mary M", "initials": "MM"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Weisdorf", "given": "Daniel", "initials": "D"}, {"family": "Saber", "given": "Wael", "initials": "W"}, {"family": "Kodera", "given": "Yoshihisa", "initials": "Y"}, {"family": "Szer", "given": "Jeff", "initials": "J"}, {"family": "Jawdat", "given": "Dunia", "initials": "D"}, {"family": "Wood", "given": "William A", "initials": "WA"}, {"family": "Brazauskas", "given": "Ruta", "initials": "R"}, {"family": "Lehmann", "given": "Leslie", "initials": "L"}, {"family": "Pasquini", "given": "Marcelo C", "initials": "MC"}, {"family": "Seber", "given": "Adriana", "initials": "A"}, {"family": "Lu", "given": "Pei Hua", "initials": "PH"}, {"family": "Atsuta", "given": "Yoshiko", "initials": "Y"}, {"family": "Riches", "given": "Marcie", "initials": "M"}, {"family": "Perales", "given": "Miguel-Angel", "initials": "M"}, {"family": "Worel", "given": "Nina", "initials": "N"}, {"family": "Okamoto", "given": "Shinichiro", "initials": "S"}, {"family": "Srivastava", "given": "Alok", "initials": "A"}, {"family": "Chemaly", "given": "Roy F", "initials": "RF"}, {"family": "Cordonnier", "given": "Catherine", "initials": "C"}, {"family": "Dandoy", "given": "Christopher E", "initials": "CE"}, {"family": "Wingard", "given": "John R", "initials": "JR"}, {"family": "Kharfan-Dabaja", "given": "Mohamed A", "initials": "MA"}, {"family": "Hamadani", "given": "Mehdi", "initials": "M"}, {"family": "Majhail", "given": "Navneet S", "initials": "NS"}, {"family": "Waghmare", "given": "Alpana A", "initials": "AA"}, {"family": "Chao", "given": "Nelson", "initials": "N"}, {"family": "Kr\u00f6ger", "given": "Nicolaus", "initials": "N"}, {"family": "Shaw", "given": "Bronwen", "initials": "B"}, {"family": "Mohty", "given": "Mohamad", "initials": "M"}, {"family": "Niederwieser", "given": "Dietger", "initials": "D"}, {"family": "Greinix", "given": "Hildegard", "initials": "H"}, {"family": "Hashmi", "given": "Shahrukh K", "initials": "SK"}, {"family": "WBMT and the CIBMTR Health Services and International Studies Committee", "given": "", "initials": ""}], "type": "practice guideline", "published": "2020-12-00", "journal": {"title": "Biol Blood Marrow Transplant", "issn": "1523-6536", "issn-l": null, "volume": "26", "issue": "12", "pages": "2181-2189"}, "abstract": "The current COVID-19 pandemic, caused by SARS-CoV-2, has impacted many facets of hematopoietic cell transplantation (HCT) in both developed and developing countries. Realizing the challenges as a result of this pandemic affecting the daily practice of the HCT centers and the recognition of the variability in practice worldwide, the Worldwide Network for Blood and Marrow Transplantation (WBMT) and the Center for International Blood and Marrow Transplant Research's (CIBMTR) Health Services and International Studies Committee have jointly produced an expert opinion statement as a general guide to deal with certain aspects of HCT, including diagnostics for SARS-CoV-2 in HCT recipient, pre- and post-HCT management, donor issues, medical tourism, and facilities management. During these crucial times, which may last for months or years, the HCT community must reorganize to proceed with transplantation activity in those patients who urgently require it, albeit with extreme caution. This shared knowledge may be of value to the HCT community in the absence of high-quality evidence-based medicine. \u00a9 2020 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.", "doi": "10.1016/j.bbmt.2020.07.021", "pmid": "32717432", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1083-8791(20)30454-7"}, {"db": "pmc", "key": "PMC7380217"}], "notes": [], "created": "2020-12-07T16:12:27.503Z", "modified": "2020-12-11T12:52:49.859Z"}, {"entity": "publication", "iuid": "b5f72594dbb84c7d80156fb4fe5230aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5f72594dbb84c7d80156fb4fe5230aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5f72594dbb84c7d80156fb4fe5230aa"}}, "title": "Prospective role of thyroid disorders in monitoring COVID-19 pandemic.", "authors": [{"family": "Kumari", "given": "Kanchan", "initials": "K", "orcid": "0000-0001-7546-4174", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/895c82c727734e4a8adf3f47ebf52a8d.json"}}, {"family": "Chainy", "given": "Gagan B N", "initials": "GBN"}, {"family": "Subudhi", "given": "Umakanta", "initials": "U", "orcid": "0000-0002-8271-1513", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/32d7e301f9304e68aac214ef5bb30455.json"}}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "volume": "6", "issue": "12", "pages": "e05712", "issn-l": null}, "abstract": "COVID-19 pandemic has affected more than 200 countries and 1.3 million individuals have deceased within eleven months. Intense research on COVID-19 occurrence and prevalence enable us to understand that comorbidities play a crucial role in spread and severity of SARS-CoV-2 infection. Chronic kidney disease, diabetes, respiratory diseases and hypertension are among the various morbidities that are prevalent in symptomatic COVID-19 patients. However, the effect of altered thyroid-driven disorders cannot be ignored. Since thyroid hormone critically coordinate and regulate the major metabolism and biochemical pathways, this review is on the potential role of prevailing thyroid disorders in SARS-CoV-2 infection. Direct link of thyroid hormone with several disorders such as diabetes, vitamin D deficiency, obesity, kidney and liver disorders etc. suggests that the prevailing thyroid conditions may affect SARS-CoV-2 infection. Further, we discuss the oxidative stress-induced aging is associated with the degree of SARS-CoV-2 infection. Importantly, ACE2 protein which facilitates the host-cell entry of SARS-CoV-2 using the spike protein, are highly expressed in individuals with abnormal level of thyroid hormone. Altogether, we report that the malfunction of thyroid hormone synthesis may aggravate SARS-CoV-2 infection and thus monitoring the thyroid hormone may help in understanding the pathogenesis of COVID-19.", "doi": "10.1016/j.heliyon.2020.e05712", "pmid": "33344794", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(20)32555-X"}, {"db": "pmc", "key": "PMC7733548"}], "notes": [], "created": "2021-01-10T17:31:22.639Z", "modified": "2021-06-22T13:25:34.955Z"}, {"entity": "publication", "iuid": "d72c2b773cbc47f3bdbf32b03b3158df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d72c2b773cbc47f3bdbf32b03b3158df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d72c2b773cbc47f3bdbf32b03b3158df"}}, "title": "Perspectives and Consensus among International Orthopaedic Surgeons during Initial and Mid-lockdown Phases of Coronavirus Disease.", "authors": [{"family": "Jerome", "given": "J Terrence Jose", "initials": "JTJ"}, {"family": "Mercier", "given": "Francisco", "initials": "F"}, {"family": "Mudgal", "given": "Chaitanya S", "initials": "CS"}, {"family": "Arenas-Prat", "given": "Joan", "initials": "J"}, {"family": "Vinagre", "given": "Gustavo", "initials": "G"}, {"family": "Goorens", "given": "Chul Ki", "initials": "CK"}, {"family": "Rivera-Chavarr\u00eda", "given": "Ignacio J", "initials": "IJ"}, {"family": "Sechachalam", "given": "Sreedharan", "initials": "S"}, {"family": "Mofikoya", "given": "Bolaji", "initials": "B"}, {"family": "Thoma", "given": "Achilleas", "initials": "A"}, {"family": "Medina", "given": "Claudia", "initials": "C"}, {"family": "IlavarasuTamilmani 13", "given": "", "initials": ""}, {"family": "Henry", "given": "Mark", "initials": "M"}, {"family": "Afshar", "given": "Ahmadreza", "initials": "A"}, {"family": "Dailiana", "given": "Zoe H", "initials": "ZH"}, {"family": "Prasetyono", "given": "Theddeus O H", "initials": "TOH"}, {"family": "Artiaco", "given": "Stefano", "initials": "S"}, {"family": "Madhusudhan", "given": "Thayur R", "initials": "TR"}, {"family": "Ukaj", "given": "Skender", "initials": "S"}, {"family": "Reigstad", "given": "Ole", "initials": "O"}, {"family": "Hamada", "given": "Yoshitaka", "initials": "Y"}, {"family": "Bedi", "given": "Rajesh", "initials": "R"}, {"family": "Poggetti", "given": "Andrea", "initials": "A"}, {"family": "Al-Qattan", "given": "Mohammad Manna", "initials": "MM"}, {"family": "Siala", "given": "Mahdi", "initials": "M"}, {"family": "Viswanathan", "given": "Anand", "initials": "A"}, {"family": "Romero-Reveron", "given": "Rafael", "initials": "R"}, {"family": "Hong", "given": "Joon Pio", "initials": "JP"}, {"family": "Khalid", "given": "Kamarul Ariffin", "initials": "KA"}, {"family": "Bhaskaran", "given": "Shivashankar", "initials": "S"}, {"family": "Venkatadass", "given": "Krishnamoorthy", "initials": "K"}, {"family": "Leechavengvongs", "given": "Somsak", "initials": "S"}, {"family": "Nazim", "given": "Sifi", "initials": "S"}, {"family": "Georgescu", "given": "Alexandru Valentin", "initials": "AV"}, {"family": "Tremp", "given": "Mathias", "initials": "M"}, {"family": "Nakarmi", "given": "Kiran K", "initials": "KK"}, {"family": "Ellabban", "given": "Mohamed A", "initials": "MA"}, {"family": "Chan", "given": "Pingtak", "initials": "P"}, {"family": "Aristov", "given": "Andrey", "initials": "A"}, {"family": "Patel", "given": "Sandeep", "initials": "S"}, {"family": "Moreno-Serrano", "given": "Constanza L", "initials": "CL"}, {"family": "Rai", "given": "Shwetabh", "initials": "S"}, {"family": "Kanna", "given": "Rishi Mugesh", "initials": "RM"}, {"family": "Malshikare", "given": "Vijay A", "initials": "VA"}, {"family": "Tanabe", "given": "Katsuhisa", "initials": "K"}, {"family": "Thomas", "given": "Simon", "initials": "S"}, {"family": "Gokkus", "given": "Kemal", "initials": "K"}, {"family": "Baek", "given": "Seung-Hoon", "initials": "SH"}, {"family": "Brandt", "given": "Jerker", "initials": "J"}, {"family": "Rith", "given": "Yin", "initials": "Y"}, {"family": "Olazabal", "given": "Alfredo", "initials": "A"}, {"family": "Saaiq", "given": "Muhammad", "initials": "M"}, {"family": "Patil", "given": "Vijay", "initials": "V"}, {"family": "Jithendran", "given": "N", "initials": "N"}, {"family": "Parekh", "given": "Harshil", "initials": "H"}, {"family": "Minamikawa", "given": "Yoshitaka", "initials": "Y"}, {"family": "Atagawi", "given": "Abdulljawad Almabrouk", "initials": "AA"}, {"family": "Hadi", "given": "Jalal Ahmed", "initials": "JA"}, {"family": "Berezowsky", "given": "Claudia Arroyo", "initials": "CA"}, {"family": "Moya-Angeler", "given": "Joaquin", "initials": "J"}, {"family": "Altamirano-Cruz", "given": "Marco Antonio", "initials": "MA"}, {"family": "Galvis R", "given": "Luz Adriana", "initials": "LA"}, {"family": "Antezana", "given": "Alex", "initials": "A"}, {"family": "Paczesny", "given": "Lukasz", "initials": "L"}, {"family": "Fernandes", "given": "Carlos Henrique", "initials": "CH"}, {"family": "Asadullah", "given": "Md", "initials": "M"}, {"family": "Yuan-Shun", "given": "Lo", "initials": "L"}, {"family": "Makelov", "given": "Biser", "initials": "B"}, {"family": "Dodakundi", "given": "Chaitanya", "initials": "C"}, {"family": "Regmi", "given": "Rabindra", "initials": "R"}, {"family": "Pereira", "given": "Ganarlo Urquizo", "initials": "GU"}, {"family": "Zhang", "given": "Shuwei", "initials": "S"}, {"family": "Sayoojianadhan", "given": "Binoy", "initials": "B"}, {"family": "Callupe", "given": "Ivan", "initials": "I"}, {"family": "Rakha", "given": "Mohamed I", "initials": "MI"}, {"family": "Papes", "given": "Dino", "initials": "D"}, {"family": "Ganesan", "given": "Ramesh Prabu", "initials": "RP"}, {"family": "Mohan", "given": "Mukesh", "initials": "M"}, {"family": "Jeyaraman", "given": "Arun", "initials": "A"}, {"family": "Prabhakar", "given": "Ponnaian", "initials": "P"}, {"family": "Rajniashokan", "given": "Arungeethayan", "initials": "A"}, {"family": "Geethan", "given": "I", "initials": "I"}, {"family": "Chandrasekar", "given": "Sugavanam", "initials": "S"}, {"family": "L\u00f6w", "given": "Steffen", "initials": "S"}, {"family": "Thangavelu", "given": "Kannan", "initials": "K"}, {"family": "Giudici", "given": "Luca Dei", "initials": "LD"}, {"family": "Palanisamy", "given": "Yuvarajan", "initials": "Y"}, {"family": "Vaidyanathan", "given": "Singaravadivelu", "initials": "S"}, {"family": "Boretto", "given": "Jorge", "initials": "J"}, {"family": "Ramirez", "given": "Monica Alexandra", "initials": "MA"}, {"family": "Goundar", "given": "Thirumalaisamy Subbiah", "initials": "TS"}, {"family": "Kuppusamy", "given": "Thirumavalavan", "initials": "T"}, {"family": "Kanniyan", "given": "Kalaivanan", "initials": "K"}, {"family": "Srivastava", "given": "Atul", "initials": "A"}, {"family": "Chiu", "given": "Yung-Cheng", "initials": "YC"}, {"family": "Bhat", "given": "Anil K", "initials": "AK"}, {"family": "Gopinath", "given": "Nalli R", "initials": "NR"}, {"family": "Vasudevan", "given": "Vijayaraghavan P", "initials": "VP"}, {"family": "Abraham", "given": "Vineet", "initials": "V"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Hand Microsurg", "issn": "0974-3227", "volume": "12", "issue": "3", "pages": "135-162", "issn-l": null}, "abstract": "With a lot of uncertainty, unclear, and frequently changing management protocols, COVID-19 has significantly impacted the orthopaedic surgical practice during this pandemic crisis. Surgeons around the world needed closed introspection, contemplation, and prospective consensual recommendations for safe surgical practice and prevention of viral contamination. One hundred orthopaedic surgeons from 50 countries were sent a Google online form with a questionnaire explicating protocols for admission, surgeries, discharge, follow-up, relevant information affecting their surgical practices, difficulties faced, and many more important issues that happened during and after the lockdown. Ten surgeons critically construed and interpreted the data to form rationale guidelines and recommendations. Of the total, hand and microsurgery surgeons (52%), trauma surgeons (32%), joint replacement surgeons (20%), and arthroscopy surgeons (14%) actively participated in the survey. Surgeons from national public health care/government college hospitals (44%) and private/semiprivate practitioners (54%) were involved in the study. Countries had lockdown started as early as January 3, 2020 with the implementation of partial or complete lifting of lockdown in few countries while writing this article. Surgeons (58%) did not stop their surgical practice or clinics but preferred only emergency cases during the lockdown. Most of the surgeons (49%) had three-fourths reduction in their total patients turn-up and the remaining cases were managed by conservative (54%) methods. There was a 50 to 75% reduction in the number of surgeries. Surgeons did perform emergency procedures without COVID-19 tests but preferred reverse transcription polymerase chain reaction (RT-PCR; 77%) and computed tomography (CT) scan chest (12%) tests for all elective surgical cases. Open fracture and emergency procedures (60%) and distal radius (55%) fractures were the most commonly performed surgeries. Surgeons preferred full personal protection equipment kits (69%) with a respirator (N95/FFP3), but in the case of unavailability, they used surgical masks and normal gowns. Regional/local anesthesia (70%) remained their choice for surgery to prevent the aerosolized risk of contaminations. Essential surgical follow-up with limited persons and visits was encouraged by 70% of the surgeons, whereas teleconsultation and telerehabilitation by 30% of the surgeons. Despite the protective equipment, one-third of the surgeons were afraid of getting infected and 56% feared of infecting their near and dear ones. Orthopaedic surgeons in private practice did face 50 to 75% financial loss and have to furlough 25% staff and 50% paramedical persons. Orthopaedics meetings were cancelled, and virtual meetings have become the preferred mode of sharing the knowledge and experiences avoiding human contacts. Staying at home, reading, and writing manuscripts became more interesting and an interesting lifestyle change is seen among the surgeons. Unanimously and without any doubt all accepted the fact that COVID-19 pandemic has reached an unprecedented level where personal hygiene, hand washing, social distancing, and safe surgical practices are the viable antidotes, and they have all slowly integrated these practices into their lives. Strict adherence to local authority recommendations and guidelines, uniform and standardized norms for admission, inpatient, and discharge, mandatory RT-PCR tests before surgery and in selective cases with CT scan chest, optimizing and regularizing the surgeries, avoiding and delaying nonemergency surgeries and follow-up protocols, use of teleconsultations cautiously, and working in close association with the World Health Organization and national health care systems will provide a conducive and safe working environment for orthopaedic surgeons and their fraternity and also will prevent the resurgence of COVID-19.", "doi": "10.1055/s-0040-1713964", "pmid": "33408440", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "JHAM2000002"}, {"db": "pmc", "key": "PMC7773504"}], "notes": [], "created": "2021-01-08T07:19:07.003Z", "modified": "2021-01-08T07:19:07.024Z"}, {"entity": "publication", "iuid": "d50e4d3b23964fd892c53f371c4552f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d50e4d3b23964fd892c53f371c4552f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d50e4d3b23964fd892c53f371c4552f4"}}, "title": "Nordic welfare states\u2014still standing or changed by the COVID \u201019 crisis?", "authors": [{"family": "Greve", "given": "Bent", "initials": "B"}, {"family": "Blomquist", "given": "Paula", "initials": "P"}, {"family": "Hvinden", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "van Gerven", "given": "Minna", "initials": "M"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "Soc Policy Adm", "issn": "0144-5596", "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1111/spol.12675", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-10T17:26:19.225Z", "modified": "2021-02-26T08:47:00.226Z"}, {"entity": "publication", "iuid": "8471851f2f744e6081ff4dddaaf3a426", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8471851f2f744e6081ff4dddaaf3a426.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8471851f2f744e6081ff4dddaaf3a426"}}, "title": "Mechanisms of a Sustained Anti\u2010inflammatory Drug Response in Alveolar Macrophages Unraveled with Mathematical Modeling", "authors": [{"family": "Nyman", "given": "Elin", "initials": "E"}, {"family": "Lindh", "given": "Maria", "initials": "M"}, {"family": "L\u00f6vfors", "given": "William", "initials": "W"}, {"family": "Simonsson", "given": "Christian", "initials": "C"}, {"family": "Persson", "given": "Alexander", "initials": "A"}, {"family": "Eklund", "given": "Daniel", "initials": "D"}, {"family": "B\u00e4ckstr\u00f6m", "given": "Erica", "initials": "E"}, {"family": "Frid\u00e9n", "given": "Markus", "initials": "M"}, {"family": "Cedersund", "given": "Gunnar", "initials": "G"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "CPT Pharmacometrics Syst. Pharmacol.", "issn": "2163-8306", "issn-l": null, "volume": "9", "issue": "12", "pages": "707-717"}, "abstract": "Both initiation and suppression of inflammation are hallmarks of the immune response. If not balanced, the inflammation may cause extensive tissue damage, which is associated with common diseases, e.g., asthma and atherosclerosis. Anti-inflammatory drugs come with side effects that may be aggravated by high and fluctuating drug concentrations. To remedy this, an anti-inflammatory drug should have an appropriate pharmacokinetic half-life or better still, a sustained anti-inflammatory drug response. However, we still lack a quantitative mechanistic understanding of such sustained effects. Here, we study the anti-inflammatory response to a common glucocorticoid drug, dexamethasone. We find a sustained response 22 hours after drug removal. With hypothesis testing using mathematical modeling, we unravel the underlying mechanism-a slow release of dexamethasone from the receptor-drug complex. The developed model is in agreement with time-resolved training and testing data and is used to simulate hypothetical treatment schemes. This work opens up for a more knowledge-driven drug development to find sustained anti-inflammatory responses and fewer side effects.", "doi": "10.1002/psp4.12568", "pmid": "33217190", "labels": {"Type: Journal article": null, "Research Area: Data-driven research \u2013 models and AI": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Funder: H2020": null, "Category: Biochemistry": null, "Category: Other": null}, "xrefs": [{"db": "URL", "key": "https://gitlab.liu.se/eliny61/macrophage-model", "description": "Experimental data and data analysis code"}], "notes": [], "created": "2021-01-17T08:51:36.015Z", "modified": "2021-06-14T14:35:41.477Z"}, {"entity": "publication", "iuid": "8a9dd1c8ce0a4fdfba93cd57897cfde8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a9dd1c8ce0a4fdfba93cd57897cfde8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a9dd1c8ce0a4fdfba93cd57897cfde8"}}, "title": "MR1-Restricted T Cells with MAIT-like Characteristics Are Functionally Conserved in the Pteropid Bat Pteropus alecto", "authors": [{"family": "Leeansyah", "given": "Edwin", "initials": "E"}, {"family": "Hey", "given": "Ying Ying", "initials": "YY"}, {"family": "Sia", "given": "Wan Rong", "initials": "WR"}, {"family": "Ng", "given": "Justin Han Jia", "initials": "JHJ"}, {"family": "Gulam", "given": "Muhammad Yaaseen", "initials": "MY"}, {"family": "Boulouis", "given": "Caroline", "initials": "C"}, {"family": "Zhu", "given": "Feng", "initials": "F"}, {"family": "Ahn", "given": "Matae", "initials": "M"}, {"family": "Mak", "given": "Jeffrey Y W", "initials": "JYW"}, {"family": "Fairlie", "given": "David P", "initials": "DP"}, {"family": "Kwa", "given": "Andrea Lay Hoon", "initials": "ALH"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Wang", "given": "Lin Fa", "initials": "LF"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "iScience", "issn": "2589-0042", "issn-l": "2589-0042", "volume": "23", "issue": "12", "pages": "101876"}, "abstract": "Bats are reservoirs for a large number of viruses which have potential to cause major human disease outbreaks, including the current coronavirus disease 2019 (COVID-19) pandemic. Major efforts are underway to understand bat immune response to viruses, whereas much less is known about their immune responses to bacteria. In this study, MR1-restricted T (MR1T) cells were detected through the use of MR1 tetramers in circulation and tissues of Pteropus alecto (Pa) bats. Pa MR1T cells exhibited weak responses to MR1-presented microbial metabolites at resting state. However, following priming with MR1-presented agonist they proliferated, upregulated critical transcription factors and cytolytic proteins, and gained transient expression of Th1/17-related cytokines and antibacterial cytotoxicity. Collectively, these findings show that the Pa bat immune system encompasses an abundant and functionally conserved population of MR1T cells with mucosal-associated invariant T-like characteristics, suggesting that MR1 and MR1T cells also play a significant role in bat immune defense.", "doi": "10.1016/j.isci.2020.101876", "pmid": "33344919", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-01-08T08:31:48.988Z", "modified": "2021-02-26T08:45:03.126Z"}, {"entity": "publication", "iuid": "a08d95668e6d4fa392a1660710854a87", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a08d95668e6d4fa392a1660710854a87.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a08d95668e6d4fa392a1660710854a87"}}, "title": "Lessons from COVID-19 on the role of the state and the market in providing early testing.", "authors": [{"family": "Morel", "given": "Chantal M", "initials": "CM"}, {"family": "Lindahl", "given": "Olof", "initials": "O"}, {"family": "\u00d6zenci", "given": "Volkan", "initials": "V"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Glob Health", "issn": "2047-2986", "volume": "10", "issue": "2", "pages": "020330", "issn-l": "2047-2978"}, "abstract": null, "doi": "10.7189/jogh.10.020330", "pmid": "33110530", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "jogh-10-020330"}, {"db": "pmc", "key": "PMC7561275"}], "notes": [], "created": "2020-11-19T19:29:19.519Z", "modified": "2020-11-27T10:22:50.060Z"}, {"entity": "publication", "iuid": "f568a85ab627477b80bcfb16151c32a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f568a85ab627477b80bcfb16151c32a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f568a85ab627477b80bcfb16151c32a1"}}, "title": "Laboratory management for SARS-CoV-2 detection: a user-friendly combination of the heat treatment approach and rt-Real-time PCR testing.", "authors": [{"family": "Mancini", "given": "Fabiola", "initials": "F"}, {"family": "Barbanti", "given": "Fabrizio", "initials": "F"}, {"family": "Scaturro", "given": "Maria", "initials": "M"}, {"family": "Errico", "given": "Giulia", "initials": "G"}, {"family": "Iacobino", "given": "Angelo", "initials": "A"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Marsili", "given": "Giulia", "initials": "G"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "Rezza", "given": "Giovanni", "initials": "G"}, {"family": "Ciervo", "given": "Alessandra", "initials": "A"}, {"family": "on behalf ISS COVID-19 study group", "given": "", "initials": ""}], "type": "evaluation study", "published": "2020-12-00", "journal": {"title": "Emerg Microbes Infect", "issn": "2222-1751", "volume": "9", "issue": "1", "pages": "1393-1396", "issn-l": "2222-1751"}, "abstract": "The RNA purification is the gold standard for the detection of SARS-CoV-2 in swab samples, but it is dependent on the availability of chemical reagents. In this study, we evaluated the heat treatment method without RNA extraction as a reliable option to nucleic acid purification.", "doi": "10.1080/22221751.2020.1775500", "pmid": "32552549", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7473159"}], "notes": [], "created": "2020-12-09T07:49:54.116Z", "modified": "2021-02-26T08:46:13.606Z"}, {"entity": "publication", "iuid": "31658bdf82964e28bf165148ff841709", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/31658bdf82964e28bf165148ff841709.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/31658bdf82964e28bf165148ff841709"}}, "title": "Incidence and outcome of myocardial infarction treated with percutaneous coronary intervention during COVID-19 pandemic.", "authors": [{"family": "Mohammad", "given": "Moman A", "initials": "MA"}, {"family": "Koul", "given": "Sasha", "initials": "S"}, {"family": "Olivecrona", "given": "G\u00f6ran K", "initials": "GK"}, {"family": "G\u04e7tberg", "given": "Matthias", "initials": "M"}, {"family": "Tyd\u00e9n", "given": "Patrik", "initials": "P"}, {"family": "Rydberg", "given": "Erik", "initials": "E"}, {"family": "Scherst\u00e9n", "given": "Fredrik", "initials": "F"}, {"family": "Alfredsson", "given": "Joakim", "initials": "J"}, {"family": "Vasko", "given": "Peter", "initials": "P"}, {"family": "Omerovic", "given": "Elmir", "initials": "E"}, {"family": "Anger\u00e5s", "given": "Oskar", "initials": "O"}, {"family": "Fr\u00f6bert", "given": "Ole", "initials": "O"}, {"family": "Calais", "given": "Fredrik", "initials": "F"}, {"family": "V\u00f6lz", "given": "Sebastian", "initials": "S"}, {"family": "Ulvenstam", "given": "Anders", "initials": "A"}, {"family": "Venetsanos", "given": "Dimitrios", "initials": "D"}, {"family": "Yndigegn", "given": "Troels", "initials": "T"}, {"family": "Oldgren", "given": "Jonas", "initials": "J"}, {"family": "Sarno", "given": "Giovanna", "initials": "G"}, {"family": "Grimfj\u00e4rd", "given": "Per", "initials": "P"}, {"family": "Persson", "given": "Jonas", "initials": "J"}, {"family": "Witt", "given": "Nils", "initials": "N"}, {"family": "Ostenfeld", "given": "Ellen", "initials": "E"}, {"family": "Lindahl", "given": "Bertil", "initials": "B"}, {"family": "James", "given": "Stefan K", "initials": "SK"}, {"family": "Erlinge", "given": "David", "initials": "D"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Heart", "issn": "1468-201X", "issn-l": null, "volume": "106", "issue": "23", "pages": "1812-1818"}, "abstract": "Most reports on the declining incidence of myocardial infarction (MI) during the COVID-19 have either been anecdotal, survey results or geographically limited to areas with lockdowns. We examined the incidence of MI during the COVID-19 pandemic in Sweden, which has remained an open society with a different public health approach fighting COVID-19.\r\n\r\nWe assessed the incidence rate (IR) as well as the incidence rate ratios (IRRs) of all MI referred for coronary angiography in Sweden using the nationwide Swedish Coronary Angiography and Angioplasty Registry (SCAAR), during the COVID-19 pandemic in Sweden (1 March 2020-7 May 2020) in relation to the same days 2015-2019.\r\n\r\nA total of 2443 MIs were referred for coronary angiography during the COVID-19 pandemic resulting in an IR 36 MIs/day (204 MIs/100 000 per year) compared with 15 213 MIs during the reference period with an IR of 45 MIs/day (254 MIs/100 000 per year) resulting in IRR of 0.80, 95% CI (0.74 to 0.86), p<0.001. Results were consistent in all investigated patient subgroups, indicating no change in patient category seeking cardiac care. Kaplan-Meier event rates for 7-day case fatality were 439 (2.3%) compared with 37 (2.9%) (HR: 0.81, 95% CI (0.58 to 1.13), p=0.21). Time to percutaneous coronary intervention (PCI) was shorter during the pandemic and PCI was equally performed, indicating no change in quality of care during the pandemic.\r\n\r\nThe COVID-19 pandemic has significantly reduced the incidence of MI referred for invasive treatment strategy. No differences in overall short-term case fatality or quality of care indicators were observed.", "doi": "10.1136/heartjnl-2020-317685", "pmid": "33023905", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "heartjnl-2020-317685"}, {"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-12-01T18:13:48.157Z", "modified": "2021-02-26T08:46:59.885Z"}, {"entity": "publication", "iuid": "6aa068c605fd4b8bbbdbdb4c583803aa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6aa068c605fd4b8bbbdbdb4c583803aa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6aa068c605fd4b8bbbdbdb4c583803aa"}}, "title": "In Conversation with a Frontline Worker in a Care Home in Sweden during the COVID-19 Pandemic.", "authors": [{"family": "Kabir", "given": "Zarina N", "initials": "ZN"}, {"family": "Bostr\u00f6m", "given": "Anne-Marie", "initials": "A"}, {"family": "Konradsen", "given": "Hanne", "initials": "H"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Cross Cult Gerontol", "issn": "1573-0719", "issn-l": null, "volume": "35", "issue": "4", "pages": "493-500"}, "abstract": null, "doi": "10.1007/s10823-020-09415-7", "pmid": "33015728", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10823-020-09415-7"}, {"db": "pmc", "key": "PMC7533166"}], "notes": [], "created": "2020-12-03T08:52:20.615Z", "modified": "2022-11-23T09:03:41.112Z"}, {"entity": "publication", "iuid": "19007ffe053f4ce0a17b43ea23ac2ff0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19007ffe053f4ce0a17b43ea23ac2ff0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19007ffe053f4ce0a17b43ea23ac2ff0"}}, "title": "Impact of COVID-19 in paediatric early-phase cancer clinical trials in Europe: A report from the Innovative Therapies for Children with Cancer (ITCC) consortium.", "authors": [{"family": "Rubio-San-Sim\u00f3n", "given": "Alba", "initials": "A"}, {"family": "Andr\u00e9", "given": "Nicolas", "initials": "N"}, {"family": "Cefalo", "given": "Maria Giuseppina", "initials": "MG"}, {"family": "Aerts", "given": "Isabelle", "initials": "I"}, {"family": "Casta\u00f1eda", "given": "Alicia", "initials": "A"}, {"family": "Benezech", "given": "Sarah", "initials": "S"}, {"family": "Makin", "given": "Guy", "initials": "G"}, {"family": "van Eijkelenburg", "given": "Natasha", "initials": "N"}, {"family": "Nysom", "given": "Karsten", "initials": "K"}, {"family": "Marshall", "given": "Lynley", "initials": "L"}, {"family": "Gambart", "given": "Marion", "initials": "M"}, {"family": "Hladun", "given": "Raquel", "initials": "R"}, {"family": "Rossig", "given": "Claudia", "initials": "C"}, {"family": "Bergamaschi", "given": "Luca", "initials": "L"}, {"family": "Fagioli", "given": "Franca", "initials": "F"}, {"family": "Carpenter", "given": "Ben", "initials": "B"}, {"family": "Ducassou", "given": "Stephane", "initials": "S"}, {"family": "Owens", "given": "Cormac", "initials": "C"}, {"family": "\u00d8ra", "given": "Ingrid", "initials": "I"}, {"family": "Ribelles", "given": "Antonio Juan", "initials": "AJ"}, {"family": "De Wilde", "given": "Bram", "initials": "B"}, {"family": "Guerra-Garc\u00eda", "given": "Pilar", "initials": "P"}, {"family": "Strullu", "given": "Marion", "initials": "M"}, {"family": "Rizzari", "given": "Carmelo", "initials": "C"}, {"family": "Ek", "given": "Torben", "initials": "T"}, {"family": "Hettmer", "given": "Simone", "initials": "S"}, {"family": "Gerber", "given": "Nicolas U", "initials": "NU"}, {"family": "Rawlings", "given": "Christine", "initials": "C"}, {"family": "Diezi", "given": "Manuel", "initials": "M"}, {"family": "Palmu", "given": "Sauli", "initials": "S"}, {"family": "Ruggiero", "given": "Antonio", "initials": "A"}, {"family": "Verd\u00fa", "given": "Jaime", "initials": "J"}, {"family": "de Rojas", "given": "Teresa", "initials": "T"}, {"family": "Vassal", "given": "Gilles", "initials": "G"}, {"family": "Geoerger", "given": "Birgit", "initials": "B"}, {"family": "Moreno", "given": "Lucas", "initials": "L"}, {"family": "Bautista", "given": "Francisco", "initials": "F"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Eur J Cancer", "issn": "1879-0852", "issn-l": "0959-8049", "volume": "141", "issue": null, "pages": "82-91"}, "abstract": "Data regarding real-world impact on cancer clinical research during COVID-19 are scarce. We analysed the impact of the COVID-19 pandemic on the conduct of paediatric cancer phase I-II trials in Europe through the experience of the Innovative Therapies for Children with Cancer (ITCC).\r\n\r\nA survey was sent to all ITCC-accredited early-phase clinical trial hospitals including questions about impact on staff activities, recruitment, patient care, supply of investigational products and legal aspects, between 1st March and 30th April 2020.\r\n\r\nThirty-one of 53 hospitals from 12 countries participated. Challenges reported included staff constraints (30% drop), reduction in planned monitoring activity (67% drop of site initiation visits and 64% of monitoring visits) and patient recruitment (61% drop compared with that in 2019). The percentage of phase I, phase II trials and molecular platforms closing to recruitment in at least one site was 48.5%, 61.3% and 64.3%, respectively. In addition, 26% of sites had restrictions on performing trial assessments because of local contingency plans. Almost half of the units suffered impact upon pending contracts. Most hospitals (65%) are planning on improving organisational and structural changes.\r\n\r\nThe study reveals a profound disruption of paediatric cancer early-phase clinical research due to the COVID-19 pandemic across Europe. Reported difficulties affected both patient care and monitoring activity. Efforts should be made to reallocate resources to avoid lost opportunities for patients and to allow the continued advancement of oncology research. Identified adaptations to clinical trial procedures may be integrated to increase preparedness of clinical research to futures crises.", "doi": "10.1016/j.ejca.2020.09.024", "pmid": "33129040", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0959-8049(20)31029-7"}, {"db": "pmc", "key": "PMC7546235"}], "notes": [], "created": "2020-12-01T15:02:28.027Z", "modified": "2021-02-26T08:46:59.838Z"}, {"entity": "publication", "iuid": "a4de5d5c53974077a4b1cc5e40718bfd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a4de5d5c53974077a4b1cc5e40718bfd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a4de5d5c53974077a4b1cc5e40718bfd"}}, "title": "Guidance regarding COVID-19 for survivors of childhood, adolescent, and young adult cancer: A statement from the International Late Effects of Childhood Cancer Guideline Harmonization Group.", "authors": [{"family": "Verbruggen", "given": "Lisanne C", "initials": "LC"}, {"family": "Wang", "given": "Yuehan", "initials": "Y"}, {"family": "Armenian", "given": "Saro H", "initials": "SH"}, {"family": "Ehrhardt", "given": "Matthew J", "initials": "MJ"}, {"family": "van der Pal", "given": "Helena J H", "initials": "HJH"}, {"family": "van Dalen", "given": "Elvira C", "initials": "EC"}, {"family": "van As", "given": "Jorrit W", "initials": "JW"}, {"family": "Bardi", "given": "Edit", "initials": "E"}, {"family": "Baust", "given": "Katja", "initials": "K"}, {"family": "Berger", "given": "Claire", "initials": "C"}, {"family": "Castagnola", "given": "Elio", "initials": "E"}, {"family": "Devine", "given": "Katie A", "initials": "KA"}, {"family": "Gebauer", "given": "Judith", "initials": "J"}, {"family": "Marchak", "given": "Jordan Gilleland", "initials": "JG"}, {"family": "Glaser", "given": "Adam W", "initials": "AW"}, {"family": "Groll", "given": "Andreas H", "initials": "AH"}, {"family": "Haeusler", "given": "Gabrielle M", "initials": "GM"}, {"family": "den Hartogh", "given": "Jaap", "initials": "J"}, {"family": "Haupt", "given": "Riccardo", "initials": "R"}, {"family": "Hjorth", "given": "Lars", "initials": "L"}, {"family": "Kato", "given": "Miho", "initials": "M"}, {"family": "Kep\u00e1k", "given": "Tom\u00e1\u0161", "initials": "T"}, {"family": "Koopman", "given": "Maria M W Rianne", "initials": "MMWR"}, {"family": "Langer", "given": "Thorsten", "initials": "T"}, {"family": "Maeda", "given": "Miho", "initials": "M"}, {"family": "Michel", "given": "Gisela", "initials": "G"}, {"family": "Muraca", "given": "Monica", "initials": "M"}, {"family": "Nathan", "given": "Paul C", "initials": "PC"}, {"family": "van den Oever", "given": "Selina R", "initials": "SR"}, {"family": "Pavasovic", "given": "Vesna", "initials": "V"}, {"family": "Sato", "given": "Satomi", "initials": "S"}, {"family": "Schulte", "given": "Fiona", "initials": "F"}, {"family": "Sung", "given": "Lillian", "initials": "L"}, {"family": "Tissing", "given": "Wim", "initials": "W"}, {"family": "Uyttebroeck", "given": "Anne", "initials": "A"}, {"family": "Mulder", "given": "Ren\u00e9e L", "initials": "RL"}, {"family": "Kuehni", "given": "Claudia", "initials": "C"}, {"family": "Skinner", "given": "Roderick", "initials": "R"}, {"family": "Hudson", "given": "Melissa M", "initials": "MM"}, {"family": "Kremer", "given": "Leontien C M", "initials": "LCM"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Pediatr Blood Cancer", "issn": "1545-5017", "volume": "67", "issue": "12", "pages": "e28702", "issn-l": null}, "abstract": "Childhood, adolescent, and young adult (CAYA) cancer survivors may be at risk for a severe course of COVID-19. Little is known about the clinical course of COVID-19 in CAYA cancer survivors, or if additional preventive measures are warranted. We established a working group within the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) to summarize existing evidence and worldwide recommendations regarding evidence about factors/conditions associated with risk for a severe course of COVID-19 in CAYA cancer survivors, and to develop a consensus statement to provide guidance for healthcare practitioners and CAYA cancer survivors regarding COVID-19.", "doi": "10.1002/pbc.28702", "pmid": "32969160", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7537044"}], "notes": [], "created": "2020-12-03T15:09:18.905Z", "modified": "2020-12-03T15:09:45.512Z"}, {"entity": "publication", "iuid": "7bfa4880a578414c8706043aed8fc6e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7bfa4880a578414c8706043aed8fc6e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7bfa4880a578414c8706043aed8fc6e7"}}, "title": "Good old BCG - what a century-old vaccine can contribute to modern medicine.", "authors": [{"family": "Locht", "given": "C", "initials": "C"}, {"family": "Lerm", "given": "M", "initials": "M"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": "288", "issue": "6", "pages": "611-613", "issn-l": null}, "abstract": null, "doi": "10.1111/joim.13195", "pmid": "33315299", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-21T10:17:15.240Z", "modified": "2021-01-08T12:32:15.992Z"}, {"entity": "publication", "iuid": "379f21c57926472b8d4a756b34ca57bb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/379f21c57926472b8d4a756b34ca57bb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/379f21c57926472b8d4a756b34ca57bb"}}, "title": "Feasibility of telehealth in the management of autoimmune hepatitis before and during the COVID-19 pandemic.", "authors": [{"family": "Efe", "given": "Cumali", "initials": "C"}, {"family": "Sim\u015fek", "given": "Cem", "initials": "C"}, {"family": "Bat\u0131bay", "given": "Ersin", "initials": "E"}, {"family": "Cal\u0131\u015fkan", "given": "Ali R\u0131za", "initials": "AR"}, {"family": "Wahlin", "given": "Staffan", "initials": "S"}], "type": "comparative study", "published": "2020-12-00", "journal": {"title": "Expert Rev Gastroenterol Hepatol", "issn": "1747-4132", "issn-l": null, "volume": "14", "issue": "12", "pages": "1215-1219"}, "abstract": "We aimed to evaluate the feasibility of telehealth in the management of patients with autoimmune hepatitis (AIH). The COVID-19 outbreak during the study period provided an opportunity to evaluate any pandemic influence on how telehealth was perceived by patients and physicians.\r\n\r\nWe included patients with AIH who were followed in the Harran University hospital, Turkey. Patients were managed by either remote telehealth or standard care.\r\n\r\nA total of 46 (telehealth, n=19 and standard care, n= 27) patients (40 female) with a median age of 32 (range 17-74) years at diagnosis were included in the study. Until the start of the COVID-19 pandemic, the rates of biochemical remission and relapse after remission were similar in the telehealth and standard care groups (89.5% vs. 89.1% and 15.8% vs. 25.9%, p=ns, for both). The telehealth group maintained remission significantly better than the standard care group (100% vs. 77.3%, p=0.035) during the COVID-19 period. All relapses were due to non-adherence to therapy. Psychiatric problems, pregnancy-related issues and drug side-effects could all be managed remotely by telehealth.\r\n\r\nIn this study, we show for the first time that telehealth is a feasible alternative for managing AIH, both under normal circumstances and during the COVID-19 pandemic.\r\n\r\nAutoimmune hepatitis (AIH) requires long-life lifelong immunosuppression and follow-up for most patients. The use of telehealth may be an alternative way to evaluate these patients remotely. We show for the first time that telehealth is effective and useful in the management of AIH in regular time as well during COVID-19. We hope that our study can extend use of telehealth in the evaluation of patients with other causes of chronic liver disease.", "doi": "10.1080/17474124.2020.1822734", "pmid": "32909852", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2020-12-03T15:51:11.527Z", "modified": "2021-02-26T08:46:59.903Z"}, {"entity": "publication", "iuid": "9f6673a28f7a47d5a6129c5e51f0dcfd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f6673a28f7a47d5a6129c5e51f0dcfd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f6673a28f7a47d5a6129c5e51f0dcfd"}}, "title": "Factors related to preventive COVID-19 infection behaviors among people with mental illness.", "authors": [{"family": "Chang", "given": "Kun-Chia", "initials": "K"}, {"family": "Strong", "given": "Carol", "initials": "C"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Formos Med Assoc", "issn": "0929-6646", "issn-l": null, "volume": "119", "issue": "12", "pages": "1772-1780"}, "abstract": "Because of the spread of novel coronavirus disease 2019 (COVID-2019), preventive COVID-19 infection behaviors become important for individuals, especially those who are vulnerable. The present study proposes a model to explain the preventive COVID-19 infection behaviors among people with mental illness in Taiwan.\r\n\r\nA cross-sectional design was carried out and 414 patients with mental illness (230 males [55.6%]; mean age = 46.32 [SD = 10.86]) agreed to participate in the study. All the participants completed the Preventive COVID-19 Infection Behaviors Scale, Self-Stigma Scale-Short, Believing COVID-19 Information Scale, Fear of COVID-19 Scale, and Depression Anxiety Stress Scale-21. Regression models and structural equation modeling (SEM) were applied to examine the factors associated with preventive COVID-19 infection behaviors.\r\n\r\nBoth regression models and SEM showed that trust in COVID-19 information sources (standardized coefficient [\u03b2] = 0.211 in regression; \u03b2 = 0.194 in SEM) and fear of COVID-19 (\u03b2 = -0.128 in regression; \u03b2 = -0.223 in SEM) significantly explained preventive behaviors among individuals with mental illness. The SEM further showed that fear of COVID-19 was significantly explained by trust in COVID-19 information sources (\u03b2 = 0.220) and self-stigma (\u03b2 = 0.454).\r\n\r\nBased on the results, healthcare providers should help individuals with mental illness reduce self-stigma and fear of COVID-19 which would consequently improve their preventive COVID-19 infection behaviors. Moreover, improving trust in COVID-19 information sources for individuals with mental illness may be another method to improve their preventive behaviors.", "doi": "10.1016/j.jfma.2020.07.032", "pmid": "32773260", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0929-6646(20)30344-2"}, {"db": "pmc", "key": "PMC7388748"}], "notes": [], "created": "2020-12-07T13:33:24.123Z", "modified": "2021-02-26T08:47:00.110Z"}, {"entity": "publication", "iuid": "ca7515e94a4946148ea2fe65f49320d8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ca7515e94a4946148ea2fe65f49320d8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ca7515e94a4946148ea2fe65f49320d8"}}, "title": "Epidemiological characteristics of COVID-19 cases and estimates of the reproductive numbers 1 month into the epidemic, Italy, 28 January to 31 March 2020.", "authors": [{"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Ajelli", "given": "Marco", "initials": "M"}, {"family": "Andrianou", "given": "Xanthi D", "initials": "XD"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Del Manso", "given": "Martina", "initials": "M"}, {"family": "Fabiani", "given": "Massimo", "initials": "M"}, {"family": "Bellino", "given": "Stefania", "initials": "S"}, {"family": "Boros", "given": "Stefano", "initials": "S"}, {"family": "Urdiales", "given": "Alberto Mateo", "initials": "AM"}, {"family": "Marziano", "given": "Valentina", "initials": "V"}, {"family": "Rota", "given": "Maria Cristina", "initials": "MC"}, {"family": "Filia", "given": "Antonietta", "initials": "A"}, {"family": "D'Ancona", "given": "Fortunato", "initials": "F"}, {"family": "Siddu", "given": "Andrea", "initials": "A"}, {"family": "Punzo", "given": "Ornella", "initials": "O"}, {"family": "Trentini", "given": "Filippo", "initials": "F"}, {"family": "Guzzetta", "given": "Giorgio", "initials": "G"}, {"family": "Poletti", "given": "Piero", "initials": "P"}, {"family": "Stefanelli", "given": "Paola", "initials": "P"}, {"family": "Castrucci", "given": "Maria Rita", "initials": "MR"}, {"family": "Ciervo", "given": "Alessandra", "initials": "A"}, {"family": "Di Benedetto", "given": "Corrado", "initials": "C"}, {"family": "Tallon", "given": "Marco", "initials": "M"}, {"family": "Piccioli", "given": "Andrea", "initials": "A"}, {"family": "Brusaferro", "given": "Silvio", "initials": "S"}, {"family": "Rezza", "given": "Giovanni", "initials": "G"}, {"family": "Merler", "given": "Stefano", "initials": "S"}, {"family": "Pezzotti", "given": "Patrizio", "initials": "P"}, {"family": "COVID-19 working group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "49", "issn-l": null}, "abstract": "BackgroundOn 20 February 2020, a locally acquired coronavirus disease (COVID-19) case was detected in Lombardy, Italy. This was the first signal of ongoing transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the country. The number of cases in Italy increased rapidly and the country became the first in Europe to experience a SARS-CoV-2 outbreak.AimOur aim was to describe the epidemiology and transmission dynamics of the first COVID-19 cases in Italy amid ongoing control measures.MethodsWe analysed all RT-PCR-confirmed COVID-19 cases reported to the national integrated surveillance system until 31 March 2020. We provide a descriptive epidemiological summary and estimate the basic and net reproductive numbers by region.ResultsOf the 98,716 cases of COVID-19 analysed, 9,512 were healthcare workers. Of the 10,943 reported COVID-19-associated deaths (crude case fatality ratio: 11.1%) 49.5% occurred in cases older than 80 years. Male sex and age were independent risk factors for COVID-19 death. Estimates of R 0 varied between 2.50 (95% confidence interval (CI): 2.18-2.83) in Tuscany and 3.00 (95% CI: 2.68-3.33) in Lazio. The net reproduction number Rt in northern regions started decreasing immediately after the first detection.ConclusionThe COVID-19 outbreak in Italy showed a clustering onset similar to the one in Wuhan, China. R0 at 2.96 in Lombardy combined with delayed detection explains the high case load and rapid geographical spread. Overall, Rt in Italian regions showed early signs of decrease, with large diversity in incidence, supporting the importance of combined non-pharmacological control measures.", "doi": "10.2807/1560-7917.ES.2020.25.49.2000790", "pmid": "33303064", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2020-12-13T07:20:07.307Z", "modified": "2021-02-26T08:47:00.193Z"}, {"entity": "publication", "iuid": "1e5d9f78dde24cba9062f2039ddf6fd7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1e5d9f78dde24cba9062f2039ddf6fd7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1e5d9f78dde24cba9062f2039ddf6fd7"}}, "title": "Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells.", "authors": [{"family": "Appelberg", "given": "Sofia", "initials": "S"}, {"family": "Gupta", "given": "Soham", "initials": "S"}, {"family": "Svensson Akusj\u00e4rvi", "given": "Sara", "initials": "S"}, {"family": "Ambikan", "given": "Anoop T", "initials": "AT"}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "Saccon", "given": "Elisa", "initials": "E"}, {"family": "V\u00e9gv\u00e1ri", "given": "\u00c1kos", "initials": "\u00c1"}, {"family": "Benfeitas", "given": "Rui", "initials": "R"}, {"family": "Sperk", "given": "Maike", "initials": "M"}, {"family": "St\u00e5hlberg", "given": "Marie", "initials": "M"}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Singh", "given": "Kamal", "initials": "K"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Emerg Microbes Infect", "issn": "2222-1751", "issn-l": "2222-1751", "volume": "9", "issue": "1", "pages": "1748-1760"}, "abstract": "How severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections engage cellular host pathways and innate immunity in infected cells remains largely elusive. We performed an integrative proteo-transcriptomics analysis in SARS-CoV-2 infected Huh7 cells to map the cellular response to the invading virus over time. We identified four pathways, ErbB, HIF-1, mTOR and TNF signaling, among others that were markedly modulated during the course of the SARS-CoV-2 infection in vitro. Western blot validation of the downstream effector molecules of these pathways revealed a dose-dependent activation of Akt, mTOR, S6K1 and 4E-BP1 at 24 hours post infection (hpi). However, we found a significant inhibition of HIF-1\u03b1 through 24hpi and 48hpi of the infection, suggesting a crosstalk between the SARS-CoV-2 and the Akt/mTOR/HIF-1 signaling pathways. Inhibition of the mTOR signaling pathway using Akt inhibitor MK-2206 showed a significant reduction in virus production. Further investigations are required to better understand the molecular sequelae in order to guide potential therapy in the management of severe coronavirus disease 2019 (COVID-19) patients.", "doi": "10.1080/22221751.2020.1799723", "pmid": "32691695", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "SRA", "key": "PRJNA627100", "description": "Raw RNAseq data"}, {"db": "URL", "key": "10.5281/zenodo.3754718", "description": "Proteomic data"}, {"db": "URL", "key": "https://github.com/neogilab/COVID19", "description": "Data analysis code"}], "notes": [], "created": "2020-11-18T16:47:18.250Z", "modified": "2021-02-26T08:45:47.926Z"}, {"entity": "publication", "iuid": "05363d49d5664a15846bc90192ce1f7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/05363d49d5664a15846bc90192ce1f7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/05363d49d5664a15846bc90192ce1f7e"}}, "title": "Development and external validation of a COVID-19 mortality risk prediction algorithm: a multicentre retrospective cohort study", "authors": [{"family": "Mei", "given": "Jin", "initials": "J"}, {"family": "Hu", "given": "Weihua", "initials": "W"}, {"family": "Chen", "given": "Qijian", "initials": "Q"}, {"family": "Li", "given": "Chang", "initials": "C"}, {"family": "Chen", "given": "Zaishu", "initials": "Z"}, {"family": "Fan", "given": "Yanjie", "initials": "Y"}, {"family": "Tian", "given": "Shuwei", "initials": "S"}, {"family": "Zhang", "given": "Zhuheng", "initials": "Z"}, {"family": "Li", "given": "Bin", "initials": "B"}, {"family": "Ye", "given": "Qifa", "initials": "Q"}, {"family": "Yue", "given": "Jiang", "initials": "J"}, {"family": "Wang", "given": "Qiao Li", "initials": "QL"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "BMJ Open", "issn": "2044-6055", "volume": "10", "issue": "12", "pages": "e044028", "issn-l": "2044-6055"}, "abstract": null, "doi": "10.1136/bmjopen-2020-044028", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-01-10T17:29:16.471Z", "modified": "2021-02-26T08:46:59.808Z"}, {"entity": "publication", "iuid": "75453bffbf5d4bd8809071c66b55abe7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/75453bffbf5d4bd8809071c66b55abe7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/75453bffbf5d4bd8809071c66b55abe7"}}, "title": "Depression, anxiety, and stress mediate the associations between internet gaming disorder, insomnia, and quality of life during the COVID-19 outbreak.", "authors": [{"family": "Fazeli", "given": "Sara", "initials": "S"}, {"family": "Mohammadi Zeidi", "given": "Isa", "initials": "I"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Namdar", "given": "Peyman", "initials": "P"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Addict Behav Rep", "issn": "2352-8532", "issn-l": null, "volume": "12", "issue": null, "pages": "100307"}, "abstract": "For many individuals, the COVID-19 outbreak has increased their psychological distress, changed their behaviors, and impacted their health. With more time spent indoors, many individuals have engaged in increased videogame playing. However, the associations between such behaviors during the COVID-19 outbreak period is unclear.\r\n\r\nThe present study examined the mediating role of psychological distress (depression, anxiety, and stress) in the association between internet gaming disorder (IGD) and two health outcomes (insomnia quality of life) among adolescents during this COVID-19 pandemic.\r\n\r\nA cross-sectional study comprising adolescents ( N = 1512) aged 13-18 years (mean age = 15.51 years) was utilized to assess measures on insomnia, depression, anxiety, and stress, IGD, and quality of life during the COVID-19 pandemic.\r\n\r\nThere were small to large significant relationships between the variables. Psychological distress (i.e., depression, anxiety, and stress) served as a strong mediator in the association between IGD and insomnia and quality of life. IGD directly influenced insomnia and quality of life among the participants.\r\n\r\nIGD is associated with different psychosocial outcomes comprising multiple pathways. Parents need to pay special attention to how much time and how frequently their children play videogames. Parents may need to assist their children in coping with psychological distress during the ongoing COVID-19 pandemic period.", "doi": "10.1016/j.abrep.2020.100307", "pmid": "33110934", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S2352-8532(20)30122-X"}, {"db": "pmc", "key": "PMC7581367"}], "notes": [], "created": "2020-12-01T15:13:19.560Z", "modified": "2022-11-23T09:04:00.250Z"}, {"entity": "publication", "iuid": "aa40739fe513445582a64d793c977c8c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aa40739fe513445582a64d793c977c8c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aa40739fe513445582a64d793c977c8c"}}, "title": "Creating and applying SIR modified compartmental model for calculation of COVID-19 lockdown efficiency.", "authors": [{"family": "Sharov", "given": "Konstantin S", "initials": "KS"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Chaos Solitons Fractals", "issn": "0960-0779", "volume": "141", "issue": null, "pages": "110295", "issn-l": null}, "abstract": "We propose a Susceptible-Infected-Recovered (SIR) modified model for Coronavirus disease - 2019 (COVID-19) spread to estimate the efficacy of lockdown measures introduced during the pandemic. As input data, we used COVID-19 epidemiological information collected in fifteen European countries either in private surveys or using official statistics. Thirteen countries implemented lockdown measures, two countries (Sweden, Iceland) not. As output parameters, we studied herd immunity level and time of formation. Comparison of these parameters was used as an indicator of effectiveness / ineffectiveness of lockdown measures. In the absence of a medical vaccine, herd immunity may be regarded as a factor of population adaptation to severe acute respiratory syndrome-related coronavirus-2, the viral pathogen causing COVID-19 disease (SARS-CoV-2), and hence COVID-19 spreading stop. We demonstrated that there is no significant difference between lockdown and no-lockdown modes of COVID-19 containment, in terms of both herd immunity level and the time of achieving its maximum. The rationale for personal and business lockdowns may be found in the avoidance of healthcare system overburdening. However, lockdowns do not prevent any virus with droplet transmission (including SARS-CoV-2) from spreading. Therefore, in case of a future viral pathogen emergence, lockdown measures efficiency should not be overestimated, as it was done almost universally in the world during COVID-19 pandemic.", "doi": "10.1016/j.chaos.2020.110295", "pmid": "32994671", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0960-0779(20)30691-3"}, {"db": "pmc", "key": "PMC7513696"}], "notes": [], "created": "2020-12-03T09:02:25.737Z", "modified": "2021-02-26T08:46:13.423Z"}, {"entity": "publication", "iuid": "f7940db8b9524e11ac7837dfecd62eaa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7940db8b9524e11ac7837dfecd62eaa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7940db8b9524e11ac7837dfecd62eaa"}}, "title": "Corrigendum to \"Depression, anxiety, and stress mediate the associations between internet gaming disorder, insomnia, and quality of life during the COVID-19 outbreak\" [Addict. Behav. Rep. 12 (2020) 100307].", "authors": [{"family": "Fazeli", "given": "Sara", "initials": "S"}, {"family": "Zeidi", "given": "Isa Mohammadi", "initials": "IM"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Namdar", "given": "Peyman", "initials": "P"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Pakpour", "given": "Amir", "initials": "A"}], "type": "published erratum", "published": "2020-12-00", "journal": {"title": "Addict Behav Rep", "issn": "2352-8532", "volume": "12", "issue": null, "pages": "100322", "issn-l": null}, "abstract": "[This corrects the article DOI: 10.1016/j.abrep.2020.100307.].", "doi": "10.1016/j.abrep.2020.100322", "pmid": "33364329", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2352-8532(20)30137-1"}, {"db": "pmc", "key": "PMC7752708"}], "notes": [], "created": "2021-01-07T13:39:25.551Z", "modified": "2021-01-10T17:24:39.710Z"}, {"entity": "publication", "iuid": "dd5e75653bbc4f49a1f4579c267db46f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dd5e75653bbc4f49a1f4579c267db46f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dd5e75653bbc4f49a1f4579c267db46f"}}, "title": "COVID-19 and Possible Pharmacological Preventive Options.", "authors": [{"family": "Duner", "given": "Pontus", "initials": "P"}, {"family": "Salehi", "given": "Albert", "initials": "A"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "J Clin Med Res", "issn": "1918-3003", "issn-l": null, "volume": "12", "issue": "12", "pages": "758-772"}, "abstract": "The dreadful fear of the coronavirus disease 2019 (COVID-19), which is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with the deadly consequences, requires rapid development of pharmacological cures. The objective of this review is to speculate about possible pharmacological options, already available today to prevent or treat the COVID-19 in the early stage of its outbreak. A literature search across PubMed and internet was conducted. A number of studies dealing with COVID-19 were identified. The data elucidated that increased pro-inflammatory and decreased anti-inflammatory cytokines in combination with hypoxia, thromboembolism and pneumonia are involved in the pathogenesis of SARS-CoV-2 infection. Although many drugs has been tested in monotherapy regimen with varying outcome or without desirable effect, there is still hope for better results by simultaneously targeting the virus itself and its symptoms. Theoretically, a mixture of at least two available antiviral drugs in combination with other anti-pathogenic and immune system-enhancing drugs or combination of antiviral drugs with convalescent plasma seems likely to have much better effect than the monotherapy regimen of either of these drugs.", "doi": "10.14740/jocmr4383", "pmid": "33447309", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7781281"}], "notes": [], "created": "2021-01-15T13:08:11.011Z", "modified": "2021-07-14T07:51:34.954Z"}, {"entity": "publication", "iuid": "f4072870300d4088af6f5c7d2c45b82e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f4072870300d4088af6f5c7d2c45b82e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f4072870300d4088af6f5c7d2c45b82e"}}, "title": "COVID-19 and NSAIDS: A Narrative Review of Knowns and Unknowns.", "authors": [{"family": "Pergolizzi", "given": "Joseph V", "initials": "JV"}, {"family": "Varrassi", "given": "Giustino", "initials": "G"}, {"family": "Magnusson", "given": "Peter", "initials": "P"}, {"family": "LeQuang", "given": "Jo Ann", "initials": "JA"}, {"family": "Paladini", "given": "Antonella", "initials": "A"}, {"family": "Taylor", "given": "Robert", "initials": "R"}, {"family": "Wollmuth", "given": "Charles", "initials": "C"}, {"family": "Breve", "given": "Frank", "initials": "F"}, {"family": "Christo", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Pain Ther", "issn": "2193-8237", "volume": "9", "issue": "2", "pages": "353-358", "issn-l": null}, "abstract": "Concern about the appropriate role of nonsteroidal anti-inflammatory drugs (NSAIDs) in COVID-19 speculate that NSAIDs, in particular ibuprofen, may upregulate the entry point for the virus, the angiotensin-converting enzyme (ACE) 2 receptors and increase susceptibility to the virus or worsen symptoms in existing disease. Adverse outcomes with COVID-19 have been linked to cytokine storm but the most effective way to address exaggerated inflammatory response is complex and unclear. The Expert Working Group on the Commission of Human Medicines in the UK and other organizations have stated that there is insufficient evidence to establish a link between ibuprofen and susceptibility to or exacerbation of COVID-19. NSAID use must also be categorized by whether the drugs are relatively low-dose over-the-counter oral products taken occasionally versus higher-dose or parenteral NSAIDs. Even if evidence emerged arguing for or against NSAIDs in this setting, it is unclear if this evidence would apply to all NSAIDs at all doses in all dosing regimens. Paracetamol (acetaminophen) has been proposed as an alternative to NSAIDs but there are issues with liver toxicity at high doses. There are clearly COVID-19 cases where NSAIDs should not be used, but there is no strong evidence that NSAIDs must be avoided in all patients with COVID-19; clinicians must weigh these choices on an individual basis.", "doi": "10.1007/s40122-020-00173-5", "pmid": "32447629", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40122-020-00173-5"}, {"db": "pmc", "key": "PMC7245573"}], "notes": [], "created": "2020-11-25T09:13:50.558Z", "modified": "2020-11-30T09:03:27.305Z"}, {"entity": "publication", "iuid": "887e076a51704634b4f27fc6fbf095bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/887e076a51704634b4f27fc6fbf095bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/887e076a51704634b4f27fc6fbf095bd"}}, "title": "Blood type A associates with critical COVID-19 and death in a Swedish cohort", "authors": [{"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}, {"family": "Persson", "given": "Barbro", "initials": "B"}, {"family": "Eriksson", "given": "Oskar", "initials": "O"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Nilsson", "given": "Bo", "initials": "B"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "Crit Care", "issn": "1364-8535", "issn-l": null, "volume": "24", "issue": "1", "pages": "496"}, "abstract": "No abstract available", "doi": "10.1186/s13054-020-03223-8", "pmid": "32787887", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Funder: VR: Special COVID-19 funding": null, "Category: Serology": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-10-30T12:03:20.383Z", "modified": "2022-02-14T06:44:05.982Z"}, {"entity": "publication", "iuid": "688925461d514ca8ba840a2028fdbcbc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/688925461d514ca8ba840a2028fdbcbc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/688925461d514ca8ba840a2028fdbcbc"}}, "title": "Amyloid nomenclature 2020: update and recommendations by the International Society of Amyloidosis (ISA) nomenclature committee.", "authors": [{"family": "Benson", "given": "Merrill D", "initials": "MD"}, {"family": "Buxbaum", "given": "Joel N", "initials": "JN"}, {"family": "Eisenberg", "given": "David S", "initials": "DS"}, {"family": "Merlini", "given": "Giampaolo", "initials": "G"}, {"family": "Saraiva", "given": "Maria J M", "initials": "MJM"}, {"family": "Sekijima", "given": "Yoshiki", "initials": "Y"}, {"family": "Sipe", "given": "Jean D", "initials": "JD"}, {"family": "Westermark", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Amyloid", "issn": "1744-2818", "volume": "27", "issue": "4", "pages": "217-222", "issn-l": null}, "abstract": "The ISA Nomenclature Committee met electronically before and directly after the XVII ISA International Symposium on Amyloidosis, which, unfortunately, had to be virtual in September 2020 due to the ongoing COVID-19 pandemic instead of a planned meeting in Tarragona in March. In addition to confirmation of basic nomenclature, several additional concepts were discussed, which are used in scientific amyloid literature. Among such concepts are cytotoxic oligomers, protofibrils, primary and secondary nucleation, seeding and cross-seeding, amyloid signature proteins, and amyloid plaques. Recommendations for their use are given. Definitions of amyloid and amyloidosis are confirmed. Possible novel human amyloid fibril proteins, appearing as 'classical' in vivo amyloid, were discussed. It was decided to include fibulin-like extracellular matrix protein 1 (amyloid protein: AEFEMP1), which appears as localised amyloid in portal veins. There are several possible amyloid proteins under investigation, and these are included in a new Table.", "doi": "10.1080/13506129.2020.1835263", "pmid": "33100054", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-01T15:32:13.763Z", "modified": "2020-12-01T15:32:13.783Z"}, {"entity": "publication", "iuid": "e7deb7bc299b44baa345a5adadb72799", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e7deb7bc299b44baa345a5adadb72799.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e7deb7bc299b44baa345a5adadb72799"}}, "title": "A timely update of global COVID-19 vaccine development.", "authors": [{"family": "Klavinskis", "given": "Linda S", "initials": "LS"}, {"family": "Liu", "given": "Margaret A", "initials": "MA"}, {"family": "Lu", "given": "Shan", "initials": "S"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Emerg Microbes Infect", "issn": "2222-1751", "issn-l": "2222-1751", "volume": "9", "issue": "1", "pages": "2379-2380"}, "abstract": "Commentary\r\nThis commentary provides an overview and links to presentations of a recent virtual congress series organized by the International Society for Vaccines (ISV) focused on COVID-19 vaccines. The series provided the academic community and vaccine developers as well as the wider general public with balanced information of the global response and resources for COVID-19 vaccines under development featuring: 1) NGOs and the regulatory perspective, 2) the status of vaccine development efforts, and 3) panel discussions to present and discuss challenges. ISV is a non-profit scientific organization whose members work on all areas relevant to vaccines. ISV plans to host additional virtual symposia including regional meetings and incorporating other topics along with COVID-19 vaccines.", "doi": "10.1080/22221751.2020.1838246", "pmid": "33059515", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7605319"}], "notes": [], "created": "2020-12-01T17:09:58.043Z", "modified": "2020-12-01T17:10:16.674Z"}, {"entity": "publication", "iuid": "eacb488d3071417b9b63d43c96028d43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eacb488d3071417b9b63d43c96028d43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eacb488d3071417b9b63d43c96028d43"}}, "title": "A systematic review and meta-analysis of the use of renin-angiotensin system drugs and COVID-19 clinical outcomes: What is the evidence so far?", "authors": [{"family": "Kurdi", "given": "Amanj", "initials": "A"}, {"family": "Abutheraa", "given": "Nouf", "initials": "N"}, {"family": "Akil", "given": "Lina", "initials": "L"}, {"family": "Godman", "given": "Brian", "initials": "B"}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Pharmacol Res Perspect", "issn": "2052-1707", "volume": "8", "issue": "6", "pages": "e00666", "issn-l": "2052-1707"}, "abstract": "Conflicting evidence exists about the effect of angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs) on COVID-19 clinical outcomes. We aimed to provide a comprehensive/updated evaluation of the effect of ACEIs/ARBs on COVID-19-related clinical outcomes, including exploration of interclass differences between ACEIs and ARBs, using a systematic review/meta-analysis approach conducted in Medline (OVID), Embase, Scopus, Cochrane library, and medRxiv from inception to 22 May 2020. English studies that evaluated the effect of ACEIs/ARBs among patients with COVID-19 were included. Studies' quality was appraised using the Newcastle-Ottawa Scale. Data were analyzed using the random-effects modeling stratified by exposure (ACEIs/ARBs, ACEIs, and ARBs). Heterogeneiity was assessed using I 2 statistic. Several subgroup analyses were conducted to explore the impact of potential confounders. Overall, 27 studies were eligible. The pooled analyses showed nonsignificant associations between ACEIs/ARBs and death (OR:0.97, 95%CI:0.75,1.27), ICU admission (OR:1.09;95%CI:0.65,1.81), death/ICU admission (OR:0.67; 95%CI:0.52,0.86), risk of COVID-19 infection (OR:1.01; 95%CI:0.93,1.10), severe infection (OR:0.78; 95%CI:0.53,1.15), and hospitalization (OR:1.15; 95%CI:0.81,1.65). However, the subgroup analyses indicated significant association between ACEIs/ARBs and hospitalization among USA studies (OR:1.59; 95%CI:1.03,2.44), peer-reviewed (OR:1.93, 95%CI:1.38,2.71), good quality and studies which reported adjusted measure of effect (OR:1.30, 95%CI:1.10,1.50). Significant differences were found between ACEIs and ARBs with the latter being significantly associated with lower risk of acquiring COVID-19 infection (OR:0.24; 95%CI: 0.17,0.34). In conclusion, high-quality evidence exists for the effect of ACEIs/ARBs on some COVID-19 clinical outcomes. For the first time, we provided evidence, albeit of low quality, on interclass differences between ACEIs and ARBs for some of the reported clinical outcomes.", "doi": "10.1002/prp2.666", "pmid": "33084232", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7575889"}], "notes": [], "created": "2020-11-26T12:18:33.090Z", "modified": "2020-11-27T11:47:58.870Z"}, {"entity": "publication", "iuid": "22808e8b71744f5eaceaef8395f820f2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/22808e8b71744f5eaceaef8395f820f2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/22808e8b71744f5eaceaef8395f820f2"}}, "title": "A population-based nationwide dataset concerning the COVID-19 pandemic and serious psychological consequences in Bangladesh", "authors": [{"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Al Mamun", "given": "Firoj", "initials": "F"}, {"family": "Hosen", "given": "Ismail", "initials": "I"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA"}], "type": "journal-article", "published": "2020-12-00", "journal": {"title": "Data Brief", "issn": "2352-3409", "volume": "33", "issue": null, "pages": "106621", "issn-l": null}, "abstract": "This paper presents the dataset concerning knowledge, preventive behavior, psychological consequences, and suicidal behavior regarding the COVID-19 pandemic in Bangladesh. Data were collected through an online based cross-sectional survey between April 1 and April 10 in 64 districts at the early stage of the COVID-19 pandemic in Bangladesh. A total of 10,067 participants' data were recruited for analysis. The survey contained items concerning (i) socio-demographic information, (ii) knowledge concerning COVID-19, (iii) behavior towards COVID-19, (iv) lockdown and economic issues, (v) assessment of fear of COVID-19, (vi) assessment of insomnia, (vii) assessment of depression, and (viii) assessment of suicidal ideation. Data were analyzed utilizing SPSS (version 22) and are represented as frequencies and percentages based on responses to the whole survey. Given that the data were collected across the whole nation, government authorities and healthcare policymakers can use the data to develop various models and/or policies regarding preventive strategies and help raise awareness through health education towards COVID-19.", "doi": "10.1016/j.dib.2020.106621", "pmid": "33344737", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.7910/DVN/YKH9C1", "description": "Raw dataset: socio-demographic characteristics, sources of information regarding COVID-19, knowledge concerning COVID-19, behavior in preventing COVID-19, etc. (N=10,067)"}, {"db": "URL", "key": "https://ars.els-cdn.com/content/image/1-s2.0-S2352340920315018-mmc1.docx", "description": "Detailed description of all study variables"}], "notes": [], "created": "2021-01-08T08:32:42.091Z", "modified": "2021-02-26T08:46:59.856Z"}, {"entity": "publication", "iuid": "a887d824552b43858617ee072044d692", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a887d824552b43858617ee072044d692.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a887d824552b43858617ee072044d692"}}, "title": "The Precision Health and Everyday Democracy (PHED) Project: Protocol for a Transdisciplinary Collaboration on Health Equity and the Role of Health in Society.", "authors": [{"family": "Strange", "given": "Michael", "initials": "M"}, {"family": "Nilsson", "given": "Carol", "initials": "C"}, {"family": "Zdravkovic", "given": "Slobodan", "initials": "S"}, {"family": "Mangrio", "given": "Elisabeth", "initials": "E"}], "type": "journal article", "published": "2020-11-30", "journal": {"title": "JMIR Res Protoc", "issn": "1929-0748", "volume": "9", "issue": "11", "pages": "e17324", "issn-l": null}, "abstract": "The project \"Precision Health and Everyday Democracy\" (PHED) is a transdisciplinary partnership that combines a diverse range of perspectives necessary for understanding the increasingly complex societal role played by modern health care and medical research. The term \"precision health\" is being increasingly used to express the need for greater awareness of environmental and genomic characteristics that may lead to divergent health outcomes between different groups within a population. Enhancing awareness of diversity has parallels with calls for \"health democracy\" and greater patient-public participation within health care and medical research. Approaching health care in this way goes beyond a narrow focus on the societal determinants of health, since it requires considering health as a deliberative space, which occurs often at the banal or everyday level. As an initial empirical focus, PHED is directed toward the health needs of marginalized migrants (including refugees and asylum seekers, as well as migrants with temporary residency, often involving a legally or economically precarious situation) as vulnerable groups that are often overlooked by health care. Developing new transdisciplinary knowledge on these groups provides the potential to enhance their wellbeing and benefit the wider society through challenging the exclusions of these groups that create pockets of extreme ill-health, which, as we see with COVID-19, should be better understood as \"acts of self-harm\" for the wider negative impact on humanity.\n\nWe aim to establish and identify precision health strategies, as well as promote equal access to quality health care, drawing upon knowledge gained from studying the health care of marginalized migrants.\n\nThe project is based in Sweden at Malm\u00f6 and Lund Universities. At the outset, the network activities do not require ethical approval where they will not involve data collection, since the purpose of PHED is to strengthen international research contacts, establish new research within precision strategies, and construct educational research activities for junior colleagues within academia. However, whenever new research is funded and started, ethical approval for that specific data collection will be sought.\n\nThe PHED project has been funded from January 1, 2019. Results of the transdisciplinary collaboration will be disseminated via a series of international conferences, workshops, and web-based materials. To ensure the network project advances toward applied research, a major goal of dissemination is to produce tools for applied research, including information to enhance health accessibility for vulnerable communities, such as marginalized migrant populations in Sweden.\n\nThere is a need to identify tools to enable the prevention and treatment of a wide spectrum of health-related outcomes and their link to social as well as environmental issues. There is also a need to identify and investigate barriers to precision health based on democratic principles.\n\nDERR1-10.2196/17324.", "doi": "10.2196/17324", "pmid": "33252352", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "v9i11e17324"}], "notes": [], "created": "2020-12-03T08:24:10.169Z", "modified": "2020-12-03T08:24:10.192Z"}, {"entity": "publication", "iuid": "9159f26c8905426ba3599eaf2c635be2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9159f26c8905426ba3599eaf2c635be2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9159f26c8905426ba3599eaf2c635be2"}}, "title": "The COVID-19 pandemic: consequences for nephrology.", "authors": [{"family": "Bruchfeld", "given": "Annette", "initials": "A"}], "type": "journal article", "published": "2020-11-30", "journal": {"title": "Nat Rev Nephrol", "issn": "1759-507X", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1038/s41581-020-00381-4", "pmid": "33257872", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41581-020-00381-4"}], "notes": [], "created": "2020-12-03T08:18:19.455Z", "modified": "2020-12-03T08:18:19.476Z"}, {"entity": "publication", "iuid": "7aeabc3750d1481bb578d56cb544837a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7aeabc3750d1481bb578d56cb544837a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7aeabc3750d1481bb578d56cb544837a"}}, "title": "Rapid review of suspected adverse drug events due to remdesivir in the WHO database; findings and implications.", "authors": [{"family": "Charan", "given": "Jaykaran", "initials": "J"}, {"family": "Kaur", "given": "Rimple Jeet", "initials": "RJ"}, {"family": "Bhardwaj", "given": "Pankaj", "initials": "P"}, {"family": "Haque", "given": "Mainul", "initials": "M"}, {"family": "Sharma", "given": "Praveen", "initials": "P"}, {"family": "Misra", "given": "Sanjeev", "initials": "S"}, {"family": "Godman", "given": "Brian", "initials": "B"}], "type": "journal article", "published": "2020-11-30", "journal": {"title": "Expert Rev Clin Pharmacol", "issn": "1751-2441", "volume": null, "issue": null, "issn-l": null}, "abstract": "Objectives: Remdesivir has shown promise in the management of patients with COVID-19 although recent studies have shown concerns with its effectiveness in practice. Despite this there is a need to document potential adverse drug events (ADEs) to guide future decisions as limited ADE data available before COVID-19 pandemic. Methods: Interrogation of WHO VigiBase\u00ae from 2015 to 2020 coupled with published studies of ADEs in COVID-19 patients. The main outcome measures are the extent of ADEs broken down by factors including age, seriousness, region and organ. Results: A total 1086 ADEs were reported from the 439 individual case reports up to 19 July 2020 in the VigiBase\u00ae, reduced to 1004 once duplicates were excluded. Almost all ADEs concerned COVID-19 patients (92.5%), with an appreciable number from the Americas (67.7%). The majority of ADEs were from males > 45 years and were serious (82.5%). An increase in hepatic enzymes (32.1%), renal injury (14.4%), rise in creatinine levels (11.2%) respiratory failure (6.4%) were the most frequently reported ADEs. Conclusions: Deterioration of liver and kidney function are frequently observed ADEs with remdesivir; consequently, patients should be monitored for these ADEs. The findings are in line with ADEs included in regulatory authority documents.", "doi": "10.1080/17512433.2021.1856655", "pmid": "33252992", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-12-03T08:22:50.485Z", "modified": "2020-12-03T08:22:50.508Z"}, {"entity": "publication", "iuid": "647022ddc42941beab3d22a7d0a54b73", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/647022ddc42941beab3d22a7d0a54b73.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/647022ddc42941beab3d22a7d0a54b73"}}, "title": "Intracerebral endotheliitis and microbleeds are neuropathological features of COVID-19.", "authors": [{"family": "Kirschenbaum", "given": "Daniel", "initials": "D"}, {"family": "Imbach", "given": "Lukas L", "initials": "LL"}, {"family": "Jane Rushing", "given": "Elisabeth", "initials": "E"}, {"family": "Frauenknecht", "given": "Katrin B M", "initials": "KBM"}, {"family": "Gascho R T", "given": "Dominic", "initials": "D"}, {"family": "Victor Ineichen", "given": "Benjamin", "initials": "B"}, {"family": "Keller", "given": "Emanuela", "initials": "E"}, {"family": "Kohler", "given": "Sibylle", "initials": "S"}, {"family": "Lichtblau", "given": "Mona", "initials": "M"}, {"family": "Reimann", "given": "Regina R", "initials": "RR"}, {"family": "Schreib", "given": "Katharina", "initials": "K"}, {"family": "Ulrich", "given": "Silvia", "initials": "S"}, {"family": "Steiger", "given": "Peter", "initials": "P"}, {"family": "Aguzzi", "given": "Adriano", "initials": "A"}, {"family": "Frontzek", "given": "Karl", "initials": "K"}], "type": "journal article", "published": "2020-11-29", "journal": {"title": "Neuropathol Appl Neurobiol", "issn": "1365-2990", "volume": null, "issue": null, "issn-l": null}, "abstract": "Coronavirus disease 19 (COVID-19), caused by infection with the severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2), has become a worldwide pandemic (1). Symptoms of COVID-19 vary widely and range from asymptomatic disease to severe pneumonia and multiorgan failure (2). A severe disease course is more likely in older patients and patients with pre-existing respiratory and cardiovascular conditions (2). Patients with severe Sars-CoV-2 infection may present with ischaemic stroke (3, 4) or even fatal intracerebral haemorrhage (5). To date, little is known about the neuropathological sequelae of COVID-19. The largest published autopsy series of COVID-19 neuropathology reported microthrombi and acute haemorrhagic infarction in a significant number of patients (6), while another more recent study found evidence of lymphocytic encephalitis and meningitis (7). Endotheliitis of the brain and extraneural organs has been shown in Sars-CoV infected patients (8). Similarly, it is a recurrent feature in the lungs and other peripheral organs of Sars-CoV-2 infected patients (9) but has not yet been reported in the central nervous system. We speculated that cerebrovascular pathology in COVID-19 patients could be a direct consequence of hitherto unidentified cerebral endotheliitis caused by Sars-CoV-2.", "doi": "10.1111/nan.12677", "pmid": "33249605", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Provided in the article: Clinical and pathological characteristics of four patients", "description": null}], "notes": [], "created": "2020-11-30T07:48:09.681Z", "modified": "2021-02-26T08:45:48.255Z"}, {"entity": "publication", "iuid": "6c4ea2411cc242ddb5a2d67e6bbbf015", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6c4ea2411cc242ddb5a2d67e6bbbf015.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6c4ea2411cc242ddb5a2d67e6bbbf015"}}, "title": "The impact of COVID-19 pandemic on pornography habits: a global analysis of Google Trends.", "authors": [{"family": "Zattoni", "given": "Fabio", "initials": "F"}, {"family": "G\u00fcl", "given": "Murat", "initials": "M"}, {"family": "Soligo", "given": "Matteo", "initials": "M"}, {"family": "Morlacco", "given": "Alessandro", "initials": "A"}, {"family": "Motterle", "given": "Giovanni", "initials": "G"}, {"family": "Collavino", "given": "Jeanlou", "initials": "J"}, {"family": "Barneschi", "given": "Andrea Celeste", "initials": "AC"}, {"family": "Moschini", "given": "Marco", "initials": "M"}, {"family": "Moro", "given": "Fabrizio Dal", "initials": "FD"}], "type": "journal article", "published": "2020-11-28", "journal": {"title": "Int J Impot Res", "issn": "1476-5489", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "As the COVID-19 spread globally, social distancing, self-isolation/quarantine, and national lockdowns have become crucial to control the pandemic. However, these measures may also lead to increases in social isolation, loneliness, and stress, which can alter the consumption of pornography habits. The aim of the study was thus to explore the interest pattern in pornography and coronavirus-themed pornography during the COVID-19 outbreak. Google Trends\u00ae was employed to determine the most popular porn websites (Porn, XNXX, PornHub, xVideos, and xHamster), and coronavirus-themed pornography worldwide and in six nations with different COVID-19 outbreak and self-isolation recommendations. We analyzed every search trend on Google\u00ae from January 9, 2020 to May 25, 2020 using \"joint point regression analysis\". Comparisons of week relative search volume (WRSV) and temporal patterns were analyzed to assess the change of interest in search terms during nations lockdowns. Paired t-test was used to compare WRSV values among the porn websites during the national lockdowns and the equivalent timespan of the weeks in the previous 4 years. The research trend of almost every keyword increased with significant inflection points for those nations with a straight \"stay at home orders\" (China, Italy, Spain, and France). \"PornHub\" and \"Porn\" showed the highest increase of interest worldwide with an average weekend percentage change (AWPC) of 4.9 and 3.8, respectively. The mean WRSV for keywords in USA and Sweden did not show a similar increase as the other nations. The WRSV percentage change with the historical data had a peak during the straight nations' lockdowns (p < 0.01). All the nations had a significant increase in WRSV coronavirus-themed pornography for each keyword (p < 0.01) with an AWPC, ranging worldwide between 18.5 and 61.8 (p < 0.01), after the beginning of self-quarantine. As strengths this study uses a big data technology to collect worldwide trend of interest, however, data are anonymous and do not allow analysis of subpopulation groups. In conclusion, we demonstrated an increased interest in pornography and coronavirus-themed pornography after the outbreak of COVID-19 in nations with a straight \"stay at home orders\".", "doi": "10.1038/s41443-020-00380-w", "pmid": "33249423", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2020-11-30T07:47:06.936Z", "modified": "2022-11-23T09:04:21.537Z"}, {"entity": "publication", "iuid": "a3c83a5854494d38acd58145a9a305c6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3c83a5854494d38acd58145a9a305c6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3c83a5854494d38acd58145a9a305c6"}}, "title": "Written Emotional Disclosure Can Promote Athletes' Mental Health and Performance Readiness During the COVID-19 Pandemic.", "authors": [{"family": "Davis", "given": "Paul A", "initials": "PA"}, {"family": "Gustafsson", "given": "Henrik", "initials": "H"}, {"family": "Callow", "given": "Nichola", "initials": "N"}, {"family": "Woodman", "given": "Tim", "initials": "T"}], "type": "journal article", "published": "2020-11-27", "journal": {"title": "Front Psychol", "issn": "1664-1078", "volume": "11", "issue": null, "pages": "599925", "issn-l": "1664-1078"}, "abstract": "The widespread effects of the coronavirus disease 2019 (COVID-19) pandemic have negatively impacted upon many athletes' mental health and increased reports of depression as well as symptoms of anxiety. Disruptions to training and competition schedules can induce athletes' emotional distress, while concomitant government-imposed restrictions (e.g., social isolation, quarantines) reduce the availability of athletes' social and emotional support. Written Emotional Disclosure (WED) has been used extensively in a variety of settings with diverse populations as a means to promote emotional processing. The expressive writing protocol has been used to a limited extent in the context of sport and predominantly in support of athletes' emotional processing during injury rehabilitation. We propose that WED offers an evidence-based treatment that can promote athletes' mental health and support their return to competition. Research exploring the efficacy of the expressive writing protocol highlights a number of theoretical models underpinning the positive effects of WED; we outline how each of these potential mechanisms can address the multidimensional complexity of the challenging circumstances arising from the COVID-19 pandemic (e.g., loss of earnings, returning to training and competition). Considerations and strategies for using WED to support athletes during the COVID-19 pandemic are presented.", "doi": "10.3389/fpsyg.2020.599925", "pmid": "33329269", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7728796"}], "notes": [], "created": "2020-12-21T09:03:40.504Z", "modified": "2021-01-10T18:12:49.509Z"}, {"entity": "publication", "iuid": "f2778adcd2b944c7983e61fdd7315dbf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f2778adcd2b944c7983e61fdd7315dbf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f2778adcd2b944c7983e61fdd7315dbf"}}, "title": "Mental health of Urban Mothers (MUM) study: a multicentre randomised controlled trial, study protocol.", "authors": [{"family": "Schwank", "given": "Simone Eliane", "initials": "SE"}, {"family": "Chung", "given": "Ho-Fung", "initials": "H"}, {"family": "Hsu", "given": "Mandy", "initials": "M"}, {"family": "Fu", "given": "Shih-Chien", "initials": "S"}, {"family": "Du", "given": "Li", "initials": "L"}, {"family": "Zhu", "given": "Liping", "initials": "L"}, {"family": "Huang", "given": "Hsuan-Ying", "initials": "H"}, {"family": "Andersson", "given": "Ewa", "initials": "E"}, {"family": "Acharya", "given": "Ganesh", "initials": "G"}], "type": "journal article", "published": "2020-11-27", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "10", "issue": "11", "pages": "e041133"}, "abstract": "Mental health disorders are common during pregnancy and the postnatal period and can have serious adverse effects on women and their children. The consequences for global mental health due to COVID-19 are likely to be significant and may have a long-term impact on the global burden of disease. Besides physical vulnerability, pregnant women are at increased risk of mental health problems such as anxiety, depression and post-traumatic stress disorder due to the consequences of social distancing. It can result in altered healthcare routines, less support from the family and friends, and in some cases, partners not being allowed to be present during prenatal visits, labour and delivery. Higher than expected, rates of perinatal anxiety and depression have been already reported during the pandemic. Pregnant women may also feel insecure and worried about the effects of COVID-19 on their unborn child if they get infected during pregnancy. Today, young urban women are used to using internet services frequently and efficiently. Therefore, providing mental health support to pregnant women via internet may be effective in ameliorating their anxiety/depression, reducing the risk of serious mental health disorders, and lead to improved maternal and perinatal outcomes.\r\n\r\nOur aim is to explore the effectiveness of a web-based psychosocial peer-to-peer support intervention in reducing the risk and severity of perinatal mental health disorders and preventing adverse pregnancy outcomes among pregnant women living in metropolitan urban settings.\r\n\r\nWe plan to conduct a multicentre prospective randomised controlled trial, Mental health of Urban Mothers trial. Pregnant women living in large metropolitan cities will be recruited using internet-based application through non-profit organisations' websites. The women who consent will be randomised to receive a web-based peer-to-peer support intervention or usual care. Data will be analysed to identify the effects of intervention on Edinburgh Postnatal Depression Score and Generalised Anxiety Disorder 7 scores as well as pregnancy outcomes. The impact of COVID-19 pandemic on maternal stress will be assesed using Impact Event Scale-R. Any differences in outcomes between cities will be addressed in subgroup analyses.\r\n\r\nThe study will be conducted according to the principles of Good Clinical Practice and will follow the ethical principles of the Declaration of Helsinki. The study protocol has been approved by the ethical review board of Chinese University of Hong Kong (IRB number 2019-8170) and Shanghai Center for Women's and Children's Health (international review board (IRB) number 2020-F001-12). The results will be disseminated at national and international scientific conferences, published in peer-reviewed medical journals and spread to the public through social media, news outlets and podcasts.\r\n\r\nNCT04363177; Trial sponsor Karolinska Institute, CLINTEC, Stockholm, Sweden.", "doi": "10.1136/bmjopen-2020-041133", "pmid": "33247023", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT04363177"}], "notes": [], "created": "2020-11-30T07:46:40.493Z", "modified": "2021-02-26T08:47:00.311Z"}, {"entity": "publication", "iuid": "8dd348ce456d47c79151aec5347fef0a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8dd348ce456d47c79151aec5347fef0a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8dd348ce456d47c79151aec5347fef0a"}}, "title": "Covid-19: What Sweden taught Scandinavia for the second wave.", "authors": [{"family": "Habib", "given": "Heba", "initials": "H"}], "type": "journal article", "published": "2020-11-27", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "371", "issue": null, "pages": "m4456", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m4456", "pmid": "33246990", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-30T07:45:48.902Z", "modified": "2020-11-30T07:45:48.924Z"}, {"entity": "publication", "iuid": "c9fdf08396a04e9cb5089bc451fd64b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9fdf08396a04e9cb5089bc451fd64b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9fdf08396a04e9cb5089bc451fd64b0"}}, "title": "Deciphering the ins and outs of SARS-CoV-2-specific T cells.", "authors": [{"family": "Perez-Potti", "given": "Andr\u00e9", "initials": "A"}, {"family": "Lange", "given": "Joshua", "initials": "J"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}], "type": "journal article", "published": "2020-11-26", "journal": {"title": "Nat Immunol", "issn": "1529-2916", "issn-l": null, "volume": "22", "issue": "1", "pages": "8-9"}, "abstract": null, "doi": "10.1038/s41590-020-00838-5", "pmid": "33244183", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41590-020-00838-5"}], "notes": [], "created": "2020-12-04T08:40:41.685Z", "modified": "2021-01-25T13:09:05.326Z"}, {"entity": "publication", "iuid": "1267273983384e4a85c6c81599143317", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1267273983384e4a85c6c81599143317.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1267273983384e4a85c6c81599143317"}}, "title": "Could Naturally Occurring Coronaviral Diseases in Animals Serve as Models for COVID-19? A Review Focusing on the Bovine Model.", "authors": [{"family": "Wensman", "given": "Jonas Johansson", "initials": "JJ"}, {"family": "Stokstad", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2020-11-26", "journal": {"title": "Pathogens", "issn": "2076-0817", "volume": "9", "issue": "12", "issn-l": "2076-0817"}, "abstract": "The current pandemic of COVID-19 has highlighted the importance of basic studies on coronaviruses (CoVs) in general, and severe acute respiratory syndrome CoV type 2 (SARS-CoV-2) in particular. CoVs have for long been studied in veterinary medicine, due to their impact on animal health and welfare, production, and economy. Several animal models using coronaviral disease in the natural host have been suggested. In this review, different animal models are discussed, with the main focus on bovine CoV (BCoV). BCoV is endemic in the cattle population worldwide and has been known and studied for several decades. SARS-CoV-2 and BCoV are both betacoronaviruses, where BCoV is highly similar to human coronavirus (HCoV) OC43, encompassing the same virus species ( Betacoronavirus 1). BCoV causes respiratory and gastrointestinal disease in young and adult cattle. This review summarizes the current knowledge of the similarities and dissimilarities between BCoV and SARS-CoV-2, as well as discussing the usage of BCoV as a model for human CoVs, including SARS-CoV-2.", "doi": "10.3390/pathogens9120991", "pmid": "33256111", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "pathogens9120991"}], "notes": [], "created": "2020-12-03T08:19:17.049Z", "modified": "2020-12-03T08:19:17.059Z"}, {"entity": "publication", "iuid": "3210460c33c34c7ea185651a27581b00", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3210460c33c34c7ea185651a27581b00.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3210460c33c34c7ea185651a27581b00"}}, "title": "Controlling the Outbreak of COVID-19: A Noncooperative Game Perspective.", "authors": [{"family": "Bairagi", "given": "Anupam Kumar", "initials": "AK"}, {"family": "Masud", "given": "Mehedi", "initials": "M"}, {"family": "Kim", "given": "Do Hyeon", "initials": "DH"}, {"family": "Munir", "given": "Md Shirajum", "initials": "MS"}, {"family": "Nahid", "given": "Abdullah-Al", "initials": "AA"}, {"family": "Abedin", "given": "Sarder Fakhrul", "initials": "SF"}, {"family": "Alam", "given": "Kazi Masudul", "initials": "KM"}, {"family": "Biswas", "given": "Sujit", "initials": "S"}, {"family": "Alshamrani", "given": "Sultan S", "initials": "SS"}, {"family": "Han", "given": "Zhu", "initials": "Z"}, {"family": "Hong", "given": "Choong Seon", "initials": "CS"}], "type": "journal article", "published": "2020-11-26", "journal": {"title": "IEEE Access", "issn": "2169-3536", "volume": "8", "pages": "215570-215581", "issn-l": null}, "abstract": "COVID-19 is a global epidemic. Till now, there is no remedy for this epidemic. However, isolation and social distancing are seemed to be effective preventive measures to control this pandemic. Therefore, in this article, an optimization problem is formulated that accommodates both isolation and social distancing features of the individuals. To promote social distancing, we solve the formulated problem by applying a noncooperative game that can provide an incentive for maintaining social distancing to prevent the spread of COVID-19. Furthermore, the sustainability of the lockdown policy is interpreted with the help of our proposed game-theoretic incentive model for maintaining social distancing where there exists a Nash equilibrium. Finally, we perform an extensive numerical analysis that shows the effectiveness of the proposed approach in terms of achieving the desired social-distancing to prevent the outbreak of the COVID-19 in a noncooperative environment. Numerical results show that the individual incentive increases more than 85% with an increasing percentage of home isolation from 25% to 100% for all considered scenarios. The numerical results also demonstrate that in a particular percentage of home isolation, the individual incentive decreases with an increasing number of individuals.", "doi": "10.1109/ACCESS.2020.3040821", "pmid": "34812371", "labels": {"Category: Other": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC8545264"}], "notes": [], "created": "2021-11-26T13:23:59.524Z", "modified": "2021-12-10T18:00:17.736Z"}, {"entity": "publication", "iuid": "b8f7c179d4c84272b7105c32a99b99ec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8f7c179d4c84272b7105c32a99b99ec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8f7c179d4c84272b7105c32a99b99ec"}}, "title": "Beginning of the Pandemic: COVID-19-Elicited Anxiety as a Predictor of Working Memory Performance.", "authors": [{"family": "Fellman", "given": "Daniel", "initials": "D"}, {"family": "Ritakallio", "given": "Liisa", "initials": "L"}, {"family": "Waris", "given": "Otto", "initials": "O"}, {"family": "Jylkk\u00e4", "given": "Jussi", "initials": "J"}, {"family": "Laine", "given": "Matti", "initials": "M"}], "type": "journal article", "published": "2020-11-26", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "11", "issue": null, "pages": "576466"}, "abstract": "Increasing evidence indicates that the coronavirus disease 2019 (COVID-19) pandemic is associated with adverse psychological effects, including heightened levels of anxiety. This study examined whether COVID-19-related anxiety levels during the early stage of the pandemic predicted demanding working memory (WM) updating performance. Altogether, 201 healthy adults (age range, 18-50) mostly from North America and the British Isles were recruited to this study via the crowdsourcing site www.prolific.co. The results showed that higher levels of COVID-19-related anxiety during the first weeks of the pandemic outbreak were associated with poorer WM performance as measured by the n-back paradigm. Critically, the unique role of COVID-19-related anxiety on WM could not be explained by demographic factors, or other psychological factors such as state and trait anxiety or fluid intelligence. Moreover, across three assessment points spanning 5-6 weeks, COVID-19-related anxiety levels tended to decrease over time. This pattern of results may reflect an initial psychological \"shock wave\" of the pandemic, the cognitive effects of which may linger for some time, albeit the initial anxiety associated with the pandemic would change with habituation and increasing information. Our results contribute to the understanding of cognitive-affective reactions to a major disaster.", "doi": "10.3389/fpsyg.2020.576466", "pmid": "33324288", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7725684"}, {"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-12-21T09:04:37.394Z", "modified": "2021-02-26T08:47:00.173Z"}, {"entity": "publication", "iuid": "d988eec958034f74b9cd5ea1eb00c0be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d988eec958034f74b9cd5ea1eb00c0be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d988eec958034f74b9cd5ea1eb00c0be"}}, "title": "Trading Health for Wealth: The Effect of COVID-19 Response Stringency.", "authors": [{"family": "Cross", "given": "Megan", "initials": "M"}, {"family": "Ng", "given": "Shu-Kay", "initials": "SK"}, {"family": "Scuffham", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2020-11-24", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "17", "issue": "23", "issn-l": null}, "abstract": "International governments' COVID-19 responses must balance human and economic health. Beyond slowing viral transmission, strict lockdowns have severe economic consequences. This work investigated response stringency, quantified by the Oxford COVID-19 Government Response Tracker's Stringency Index, and examined how restrictive interventions affected infection rates and gross domestic product (GDP) in China and OECD countries. Accounting for response timing, China imposed the most stringent restrictions, while Sweden and Japan were the least stringent. Expected GDP declines range from -8% (Japan) to -15.4% (UK). While greater restrictions generally slowed viral transmission, they failed to reach statistical significance and reduced GDP ( p = 0.006). Timing was fundamental: governments who responded to the pandemic faster saw greater reductions in viral transmission (p = 0.013), but worse decreases in GDP (p = 0.044). Thus, response stringency has a greater effect on GDP than infection rates, which are instead affected by the timing of COVID-19 interventions. Attempts to mitigate economic impacts by delaying restrictions or decreasing stringency may buoy GDP in the short term but increase infection rates, the longer-term economic consequences of which are not yet fully understood. As highly restrictive interventions were successful in some but not all countries, decision-makers must consider whether their strategies are appropriate for the country on health and economic grounds.", "doi": "10.3390/ijerph17238725", "pmid": "33255383", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph17238725"}], "notes": [], "created": "2020-12-03T08:18:31.993Z", "modified": "2020-12-03T08:18:32.007Z"}, {"entity": "publication", "iuid": "0512e611adbe4166a1cc2ff5dee38f98", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0512e611adbe4166a1cc2ff5dee38f98.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0512e611adbe4166a1cc2ff5dee38f98"}}, "title": "Social Determinants Predict Outcomes in Data From a Multi-Ethnic Cohort of 20,899 Patients Investigated for COVID-19.", "authors": [{"family": "Lundon", "given": "Dara J", "initials": "DJ"}, {"family": "Mohamed", "given": "Nihal", "initials": "N"}, {"family": "Lantz", "given": "Anna", "initials": "A"}, {"family": "Goltz", "given": "Heather H", "initials": "HH"}, {"family": "Kelly", "given": "Brian D", "initials": "BD"}, {"family": "Tewari", "given": "Ashutosh K", "initials": "AK"}], "type": "journal article", "published": "2020-11-24", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "8", "issue": null, "pages": "571364"}, "abstract": "Importance: The COVID-19 pandemic exploits existing inequalities in social determinants of health (SDOH) in disease burden and access to healthcare. Few studies have examined these emerging disparities using indicators of SDOH. Objective: To evaluate predictors of COVID-19 test positivity, morbidity, and mortality and their implications for inequalities in SDOH and for future policies and health care improvements. Design, Setting, and Participants: A cross sectional analysis was performed on all patients tested for COVID-19 on the basis of symptoms with either a history of travel to at risk regions or close contact with a confirmed case, across the Mount Sinai Health System (MSHS) up until April 26th 2020. Main Outcomes and Measures: Primary outcome was death from COVID-19 and secondary outcomes were test positivity, and morbidity (e.g., hospitalization and intubation caused by COVID-19). Results: Of 20,899 tested patients, 8,928 tested positive, 1,701 were hospitalized, 684 were intubated, and 1,179 died from COVID-19. Age, sex, race/ethnicity, New York City borough (derived from first 3 digits of zip-code), and English as preferred language were significant predictors of test positivity, hospitalization, intubation and COVID-19 mortality following multivariable logistic regression analyses. Conclusions and Relevance: People residing in poorer boroughs were more likely to be burdened by and die from COVID-19. Our results highlight the importance of integrating comprehensive SDOH data into healthcare efforts with at-risk patient populations.", "doi": "10.3389/fpubh.2020.571364", "pmid": "33324596", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7722480"}, {"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-12-21T10:01:18.157Z", "modified": "2021-02-26T08:46:59.802Z"}, {"entity": "publication", "iuid": "4f8deeb9b8fc4cb9ab821eb4ea8fe0e1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4f8deeb9b8fc4cb9ab821eb4ea8fe0e1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4f8deeb9b8fc4cb9ab821eb4ea8fe0e1"}}, "title": "Low rate of COVID-19 seroconversion in health-care workers at a Department of Infectious Diseases in Sweden during the later phase of the first wave; a prospective longitudinal seroepidemiological study.", "authors": [{"family": "Rashid-Abdi", "given": "Mulki", "initials": "M"}, {"family": "Krifors", "given": "Anders", "initials": "A"}, {"family": "S\u00e4ll\u00e9ber", "given": "Andreas", "initials": "A"}, {"family": "Eriksson", "given": "Jenny", "initials": "J"}, {"family": "M\u00e5nsson", "given": "Emeli", "initials": "E"}], "type": "journal article", "published": "2020-11-24", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "volume": null, "issue": null, "pages": "1-7", "issn-l": "2374-4235"}, "abstract": "Background: Health-care workers are at risk of contracting and transmitting SARS-CoV-2. The aim of this study was to investigate the prevalence of SARS-CoV-2 IgG antibodies and the rate of seroconversion in an environment with high exposure to SARS-CoV-2. Methods: 131 health-care workers at the Department of Infectious Diseases in V\u00e4ster\u00e5s, Sweden, were included in the study. Abbott's SARS-COV-2 IgG immunoassay was used with a signal cut-off ratio of \u22651.4. Every third week from the beginning of May, blood samples were drawn, and the participants completed a questionnaire regarding symptoms consistent with COVID-19 and the result of any SARS-CoV-2 PCR performed since the last sampling occasion. Participants with IgG antibodies against SARS-CoV-2 were re-sampled only on the sixth and last occasion. Results: At the start of the study, 18 (15%) participants had SARS-CoV-2 IgG antibodies. At the end, 25 (19%) of 131 participants were seropositive. One case of asymptomatic infection was detected, and two cases with PCR-confirmed COVID-19 did not develop IgG antibodies. Conclusion: The low rate of seroconversion during the study suggests that it is possible to prevent transmission of SARS-COV-2 in a high-exposure environment. Compliance with adequate infection control guidelines is the likely explanation of our findings.", "doi": "10.1080/23744235.2020.1849787", "pmid": "33232190", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-26T14:15:35.168Z", "modified": "2021-02-26T08:45:48.126Z"}, {"entity": "publication", "iuid": "13bdf06c2df94e9796f3ce40cb2ada46", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13bdf06c2df94e9796f3ce40cb2ada46.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13bdf06c2df94e9796f3ce40cb2ada46"}}, "title": "How to ensure we can track and trace global use of COVID-19 vaccines?", "authors": [{"family": "Vander Stichele", "given": "Robert H", "initials": "RH"}, {"family": "Hay", "given": "Christian", "initials": "C"}, {"family": "Fladvad", "given": "Malin", "initials": "M"}, {"family": "Sturkenboom", "given": "Miriam C J M", "initials": "MCJM"}, {"family": "Chen", "given": "Robert T", "initials": "RT"}], "type": "journal article", "published": "2020-11-24", "journal": {"title": "Vaccine", "issn": "1873-2518", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.vaccine.2020.11.055", "pmid": "33293161", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0264-410X(20)31508-5"}], "notes": [], "created": "2020-12-10T09:10:46.004Z", "modified": "2020-12-10T09:13:26.443Z"}, {"entity": "publication", "iuid": "aa777d31f46b4cf9948c95629e70bdf4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aa777d31f46b4cf9948c95629e70bdf4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aa777d31f46b4cf9948c95629e70bdf4"}}, "title": "Excess mortality across regions of Europe during the first wave of the COVID-19 pandemic \u2013 impact of the winter holiday travelling and government responses", "authors": [{"family": "Bj\u00f6rk", "given": "Jonas", "initials": "J"}, {"family": "Mattisson", "given": "Kristoffer", "initials": "K"}, {"family": "Ahlbom", "given": "Anders", "initials": "A"}], "type": "posted-content", "published": "2020-11-24", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.11.24.20237644", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-10T04:20:55.285Z", "modified": "2021-06-10T04:22:34.266Z"}, {"entity": "publication", "iuid": "8d08457dded94192bbd8f026ed52f527", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d08457dded94192bbd8f026ed52f527.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d08457dded94192bbd8f026ed52f527"}}, "title": "At the Epicenter of COVID-19-the Tragic Failure of the Global Supply Chain for Medical Supplies.", "authors": [{"family": "Bhaskar", "given": "Sonu", "initials": "S"}, {"family": "Tan", "given": "Jeremy", "initials": "J"}, {"family": "Bogers", "given": "Marcel L A M", "initials": "MLAM"}, {"family": "Minssen", "given": "Timo", "initials": "T"}, {"family": "Badaruddin", "given": "Hishamuddin", "initials": "H"}, {"family": "Israeli-Korn", "given": "Simon", "initials": "S"}, {"family": "Chesbrough", "given": "Henry", "initials": "H"}], "type": "journal article", "published": "2020-11-24", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "562882", "issn-l": "2296-2565"}, "abstract": "The tragic failure of the global supply chain in the face of the current coronavirus outbreak has caused acute shortages of essential frontline medical devices and personal protective equipment, crushing fear among frontline health workers and causing fundamental concerns about the sustainability of the health system. Much more coordination, integration, and management of global supply chains will be needed to mitigate the impact of the pandemics. This article describes the pressing need to revisit the governance and resilience of the supply chains that amplified the crisis at pandemic scale. We propose a model that profiles critical stockpiles and improves production efficiency through new technologies such as advanced analytics and blockchain. A new governance system that supports intervention by public-health authorities during critical emergencies is central to our recommendation, both in the face of the current crisis and to be better prepared for potential future crises. These reinforcements offer the potential to minimize the compromise of our healthcare workers and health systems due to infection exposure and build capacity toward preparedness and action for a future outbreak.", "doi": "10.3389/fpubh.2020.562882", "pmid": "33335876", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7737425"}], "notes": [], "created": "2020-12-21T08:55:50.003Z", "modified": "2021-01-10T18:09:54.149Z"}, {"entity": "publication", "iuid": "3ac4c61ae4da4f789cec2d9a7448d388", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ac4c61ae4da4f789cec2d9a7448d388.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ac4c61ae4da4f789cec2d9a7448d388"}}, "title": "S\u00e5 har Sveriges coronastrategi framst\u00e5tt under \u00e5tta m\u00e5nader", "authors": [{"family": "F Ludvigsson", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2020-11-23", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": null, "doi": null, "pmid": "33230806", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "20188"}], "notes": [], "created": "2021-02-10T18:54:12.954Z", "modified": "2021-10-14T09:45:18.560Z"}, {"entity": "publication", "iuid": "9b858f8b0cb944f5ad94af6fda6c93b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b858f8b0cb944f5ad94af6fda6c93b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b858f8b0cb944f5ad94af6fda6c93b9"}}, "title": "Pore-Scale Transport and Two-Phase Fluid Structures in Fibrous Porous Layers: Application to Fuel Cells and Beyond.", "authors": [{"family": "Farzaneh", "given": "Meisam", "initials": "M"}, {"family": "Str\u00f6m", "given": "Henrik", "initials": "H"}, {"family": "Zanini", "given": "Filippo", "initials": "F"}, {"family": "Carmignato", "given": "Simone", "initials": "S"}, {"family": "Sasic", "given": "Srdjan", "initials": "S"}, {"family": "Maggiolo", "given": "Dario", "initials": "D"}], "type": "journal article", "published": "2020-11-23", "journal": {"title": "Transp Porous Media", "issn": "0169-3913", "volume": null, "issue": null, "pages": "1-26", "issn-l": null}, "abstract": "We present pore-scale simulations of two-phase flows in a reconstructed fibrous porous layer. The three-dimensional microstructure of the material, a fuel cell gas diffusion layer, is acquired via X-ray computed tomography and used as input for lattice Boltzmann simulations. We perform a quantitative analysis of the multiphase pore-scale dynamics, and we identify the dominant fluid structures governing mass transport. The results show the existence of three different regimes of transport: a fast inertial dynamics at short times, characterised by a compact uniform front, a viscous-capillary regime at intermediate times, where liquid is transported along a gradually increasing number of preferential flow paths of the size of one-two pores, and a third regime at longer times, where liquid, after having reached the outlet, is exclusively flowing along such flow paths and the two-phase fluid structures are stabilised. We observe that the fibrous layer presents significant variations in its microscopic morphology, which have an important effect on the pore invasion dynamics, and counteract the stabilising viscous force. Liquid transport is indeed affected by the presence of microstructure-induced capillary pressures acting adversely to the flow, leading to capillary fingering transport mechanism and unstable front displacement, even in the absence of hydrophobic treatments of the porous material. We propose a macroscopic model based on an effective contact angle that mimics the effects of the such a dynamic capillary pressure. Finally, we underline the significance of the results for the optimal design of face masks in an effort to mitigate the current COVID-19 pandemic.", "doi": "10.1007/s11242-020-01509-7", "pmid": "33250547", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "1509"}, {"db": "pmc", "key": "PMC7682777"}], "notes": [], "created": "2020-12-03T08:26:27.558Z", "modified": "2021-02-26T08:46:13.387Z"}, {"entity": "publication", "iuid": "5e0aca6899a0474ca133d3d6a9e52ec6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5e0aca6899a0474ca133d3d6a9e52ec6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5e0aca6899a0474ca133d3d6a9e52ec6"}}, "title": "Low prevalence of bloodstream infection and high blood culture contamination rates in patients with COVID-19.", "authors": [{"family": "Yu", "given": "David", "initials": "D"}, {"family": "Ininbergs", "given": "Karolina", "initials": "K"}, {"family": "Hedman", "given": "Karolina", "initials": "K"}, {"family": "Giske", "given": "Christian G", "initials": "CG"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "\u00d6zenci", "given": "Volkan", "initials": "V"}], "type": "journal article", "published": "2020-11-23", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "15", "issue": "11", "pages": "e0242533", "issn-l": "1932-6203"}, "abstract": "In the management of COVID-19, knowledge is lacking on the frequency of secondary bacterial infections and on how empirical antibiotic therapy should be used. In the present study, we aimed to compare blood culture (BC) results of a COVID-19 patient cohort with two cohorts of patients without detected COVID-19.\n\nUsing a retrospective cohort study design of patients subjected to BC in six tertiary care hospitals, SARS-CoV-2 positive patients from March 1 to April 30 in 2020 (COVID-19 group) were compared to patients without confirmed SARS-CoV-2 during the same period (control group-2020) and with patients sampled March 1 to April 30 in 2019 (control group-2019). The outcomes studied were proportion of BC positivity, clinically relevant growth, and contaminant growth.\n\nIn total 15,103 patients and 17,865 BC episodes were studied. Clinically relevant growth was detected in 197/3,027 (6.5%) BC episodes in the COVID-19 group compared to 717/6,663 (10.8%) in control group-2020 (p<0.0001) and 850/8,175 (10.4%) in control group-2019 (p<0.0001). Contamination was present in 255/3,027 (8.4%) BC episodes in the COVID-19 group compared to 330/6,663 (5.0%) in control group-2020 (p<0.0001) and 354/8,175 (4.3%) in control group-2019 (p<0.0001).\n\nIn COVID-19 patients, the prevalence of bloodstream bacterial infection is low and the contamination rate of BC is high. This knowledge should influence guidelines regarding blood culture sampling and empirical antibiotic therapy in COVID-19 patients.", "doi": "10.1371/journal.pone.0242533", "pmid": "33226995", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-20448"}], "notes": [], "created": "2020-11-26T14:17:26.847Z", "modified": "2021-02-26T08:45:48.234Z"}, {"entity": "publication", "iuid": "4c160f784d3e4ff1a016fabefbe69555", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4c160f784d3e4ff1a016fabefbe69555.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4c160f784d3e4ff1a016fabefbe69555"}}, "title": "Dosing of thromboprophylaxis and mortality in critically ill COVID-19 patients.", "authors": [{"family": "Jonmarker", "given": "Sandra", "initials": "S"}, {"family": "Hollenberg", "given": "Jacob", "initials": "J"}, {"family": "Dahlberg", "given": "Martin", "initials": "M"}, {"family": "Stackelberg", "given": "Otto", "initials": "O"}, {"family": "Litorell", "given": "Jacob", "initials": "J"}, {"family": "Everhov", "given": "\u00c5sa H", "initials": "\u00c5H"}, {"family": "J\u00e4rnbert-Pettersson", "given": "Hans", "initials": "H"}, {"family": "S\u00f6derberg", "given": "M\u00e5rten", "initials": "M"}, {"family": "Grip", "given": "Jonathan", "initials": "J"}, {"family": "Schandl", "given": "Anna", "initials": "A"}, {"family": "G\u00fcnther", "given": "Mattias", "initials": "M"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2020-11-23", "journal": {"title": "Crit Care", "issn": "1466-609X", "issn-l": "1364-8535", "volume": "24", "issue": "1", "pages": "653"}, "abstract": "A substantial proportion of critically ill COVID-19 patients develop thromboembolic complications, but it is unclear whether higher doses of thromboprophylaxis are associated with lower mortality rates. The purpose of the study was to evaluate the association between initial dosing strategy of thromboprophylaxis in critically ill COVID-19 patients and the risk of death, thromboembolism, and bleeding.\r\n\r\nIn this retrospective study, all critically ill COVID-19 patients admitted to two intensive care units in March and April 2020 were eligible. Patients were categorized into three groups according to initial daily dose of thromboprophylaxis: low (2500-4500 IU tinzaparin or 2500-5000 IU dalteparin), medium (> 4500 IU but < 175 IU/kilogram, kg, of body weight tinzaparin or > 5000 IU but < 200 IU/kg of body weight dalteparin), and high dose (\u2265 175 IU/kg of body weight tinzaparin or \u2265 200 IU/kg of body weight dalteparin). Thromboprophylaxis dosage was based on local standardized recommendations, not on degree of critical illness or risk of thrombosis. Cox proportional hazards regression was used to estimate hazard ratios with corresponding 95% confidence intervals of death within 28 days from ICU admission. Multivariable models were adjusted for sex, age, body mass index, Simplified Acute Physiology Score III, invasive respiratory support, and initial dosing strategy of thromboprophylaxis.\r\n\r\nA total of 152 patients were included: 67 received low-, 48 medium-, and 37 high-dose thromboprophylaxis. Baseline characteristics did not differ between groups. For patients who received high-dose prophylaxis, mortality was lower (13.5%) compared to those who received medium dose (25.0%) or low dose (38.8%), p = 0.02. The hazard ratio of death was 0.33 (95% confidence intervals 0.13-0.87) among those who received high dose, and 0.88 (95% confidence intervals 0.43-1.83) among those who received medium dose, as compared to those who received low-dose thromboprophylaxis. There were fewer thromboembolic events in the high (2.7%) vs medium (18.8%) and low-dose thromboprophylaxis (17.9%) groups, p = 0.04.\r\n\r\nAmong critically ill COVID-19 patients with respiratory failure, high-dose thromboprophylaxis was associated with a lower risk of death and a lower cumulative incidence of thromboembolic events compared with lower doses.\r\n\r\nClinicaltrials.gov NCT04412304 June 2, 2020, retrospectively registered.", "doi": "10.1186/s13054-020-03375-7", "pmid": "33225952", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-020-03375-7"}, {"db": "pmc", "key": "PMC7680989"}, {"db": "ClinicalTrials.gov", "key": "NCT04412304"}, {"db": "NA", "key": "Available on request due to privacy restrictions", "description": null}], "notes": [], "created": "2020-11-27T10:54:43.450Z", "modified": "2021-02-26T08:45:48.116Z"}, {"entity": "publication", "iuid": "27ca9b35839c4183a6c84f3ec717d99b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27ca9b35839c4183a6c84f3ec717d99b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27ca9b35839c4183a6c84f3ec717d99b"}}, "title": "Erratum to: COVID-19 healthcare demand and mortality in Sweden in response to non-pharmaceutical mitigation and suppression scenarios.", "authors": [{"family": "Sj\u00f6din", "given": "Henrik", "initials": "H"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}, {"family": "Br\u00e4nnstr\u00f6m", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Farooq", "given": "Zia", "initials": "Z"}, {"family": "Kriit", "given": "Hedi Katre", "initials": "HK"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "\u00c5str\u00f6m", "given": "Christofer", "initials": "C"}, {"family": "Thunberg", "given": "Johan", "initials": "J"}, {"family": "S\u00f6derquist", "given": "M\u00e5rten", "initials": "M"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}], "type": "journal article", "published": "2020-11-22", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "volume": null, "issue": null, "issn-l": "0300-5771"}, "abstract": null, "doi": "10.1093/ije/dyaa234", "pmid": "33221845", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5998420"}], "notes": [], "created": "2020-11-27T10:31:07.914Z", "modified": "2020-11-27T10:31:07.934Z"}, {"entity": "publication", "iuid": "2daf9c0238394a92be440a72221722f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2daf9c0238394a92be440a72221722f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2daf9c0238394a92be440a72221722f8"}}, "title": "Association between Renin-Angiotensin-Aldosterone system inhibitor use and COVID-19 Hospitalization and death: A 1,4 million patient Nation-Wide registry analysis.", "authors": [{"family": "Savarese", "given": "Gianluigi", "initials": "G"}, {"family": "Benson", "given": "Lina", "initials": "L"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Lund", "given": "Lars H", "initials": "LH"}], "type": "journal article", "published": "2020-11-22", "journal": {"title": "Eur J Heart Fail", "issn": "1879-0844", "issn-l": "1388-9842", "volume": null, "issue": null, "pages": null}, "abstract": "Renin-angiotensin-aldosterone-system inhibitors (RAASi) improve outcomes in cardiorenal disease but concerns have been raised over increased risk of incident and death from Covid-19. We investigated the association between use of angiotensin converting enzyme inhibitors (ACEi), angiotensin receptor blockers (ARB) or mineralocorticoid receptor antagonists (MRA) and Covid-19 hospitalization/death in a large nationwide population.\r\n\r\nPatients with hypertension, heart failure, diabetes, kidney disease, or ischemic heart disease registered in the Swedish National Patient Registry until February 1 st 2020 were included and followed until May 31st 2020. Covid-19 cases were defined based on hospitalization/death for Covid-19. Multivariable logistic and Cox regressions were fitted to investigate the association between ACEi/ARB and MRA and risk of hospitalization/death for Covid-19 in the overall population, and of all-cause mortality in Covid-19 cases. We performed consistency analysis to quantify the impact of potential unmeasured confounding. Of 1,387,746 patients (60% receiving ACEi/ARB and 5.8% MRA) 7,146 (0.51%) had incident hospitalization/death from Covid-19. After adjustment for 45 variables, ACEi/ARB use was associated with a reduced risk of hospitalization/death for Covid-19 (Odds Ratio [95% Confidence Interval]: 0.86[0.81-0.91]) in the overall population, and with reduced mortality in Covid-19 cases (Hazard Ratio: 0.89[0.82-0.96]). MRA use was not associated with risk of any outcome. Consistency analysis showed that unmeasured confounding would need to be large for there to be harmful signals associated with RAASi use.\r\n\r\nIn a 1.4 million nation-wide cohort, use of RAASi was not associated with increased risk of hospitalization for or death from Covid-19.", "doi": "10.1002/ejhf.2060", "pmid": "33222412", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Public Health": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [], "notes": [], "created": "2020-11-26T14:25:37.655Z", "modified": "2021-04-28T17:56:44.773Z"}, {"entity": "publication", "iuid": "8546463631214e17b48ae9f1fd895681", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8546463631214e17b48ae9f1fd895681.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8546463631214e17b48ae9f1fd895681"}}, "title": "Type I interferons promote germinal centers through B cell intrinsic signaling and dendritic cell dependent Th1 and Tfh cell lineages", "authors": [{"family": "Dahlgren", "given": "Madelene W", "initials": "MW"}, {"family": "Plumb", "given": "Adam W", "initials": "AW"}, {"family": "Niss", "given": "Kristoffer", "initials": "K"}, {"family": "Lahl", "given": "Katharina", "initials": "K"}, {"family": "Brunak", "given": "S\u00f8ren", "initials": "S"}, {"family": "Johansson-Lindbom", "given": "Bengt", "initials": "B"}], "type": "posted-content", "published": "2020-11-21", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.11.20.390625", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2021-01-15T16:17:24.701Z", "modified": "2021-07-14T07:52:57.666Z"}, {"entity": "publication", "iuid": "3a3a0fa4e51e4effa15fcd47a46ae482", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a3a0fa4e51e4effa15fcd47a46ae482.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a3a0fa4e51e4effa15fcd47a46ae482"}}, "title": "Modelling the test, trace and quarantine strategy to control the COVID-19 epidemic in the state of S\u00e3o Paulo, Brazil.", "authors": [{"family": "Amaku", "given": "Marcos", "initials": "M"}, {"family": "Covas", "given": "Dimas Tadeu", "initials": "DT"}, {"family": "Bezerra Coutinho", "given": "Francisco Antonio", "initials": "FA"}, {"family": "Azevedo Neto", "given": "Raymundo Soares", "initials": "RS"}, {"family": "Struchiner", "given": "Claudio", "initials": "C"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Massad", "given": "Eduardo", "initials": "E"}], "type": "journal article", "published": "2020-11-20", "journal": {"title": "Infect Dis Model", "issn": "2468-0427", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Testing for detecting the infection by SARS-CoV-2 is the bridge between the lockdown and the opening of society. In this paper we modelled and simulated a test-trace-and-quarantine strategy to control the COVID-19 outbreak in the State of S\u00e3o Paulo, Brasil. The State of S\u00e3o Paulo failed to adopt an effective social distancing strategy, reaching at most 59% in late March and started to relax the measures in late June, dropping to 41% in 08 August. Therefore, S\u00e3o Paulo relies heavily on a massive testing strategy in the attempt to control the epidemic. Two alternative strategies combined with economic evaluations were simulated. One strategy included indiscriminately testing the entire population of the State, reaching more than 40 million people at a maximum cost of 2.25 billion USD, that would reduce the total number of cases by the end of 2020 by 90%. The second strategy investigated testing only symptomatic cases and their immediate contacts - this strategy reached a maximum cost of 150 million USD but also reduced the number of cases by 90%. The conclusion is that if the State of S\u00e3o Paulo had decided to adopt the simulated strategy on April the 1st, it would have been possible to reduce the total number of cases by 90% at a cost of 2.25 billion US dollars for the indiscriminate strategy but at a much smaller cost of 125 million US dollars for the selective testing of symptomatic cases and their contacts.", "doi": "10.1016/j.idm.2020.11.004", "pmid": "33235942", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S2468-0427(20)30074-9"}, {"db": "pmc", "key": "PMC7677040"}], "notes": [], "created": "2020-11-27T10:28:12.415Z", "modified": "2022-11-09T08:16:52.712Z"}, {"entity": "publication", "iuid": "5dccf7ce244346c0924ee31e6852684c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5dccf7ce244346c0924ee31e6852684c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5dccf7ce244346c0924ee31e6852684c"}}, "title": "Effect of COVID-19 on maternal and neonatal services - Authors' reply.", "authors": [{"family": "Kc", "given": "Ashish", "initials": "A"}, {"family": "Kinney", "given": "Mary V", "initials": "MV"}, {"family": "Lawn", "given": "Joy E", "initials": "JE"}], "type": "letter", "published": "2020-11-20", "journal": {"title": "Lancet Glob Health", "issn": "2214-109X", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/S2214-109X(20)30486-1", "pmid": "33227257", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2214-109X(20)30486-1"}], "notes": [], "created": "2020-11-27T10:29:07.591Z", "modified": "2020-11-27T10:29:07.611Z"}, {"entity": "publication", "iuid": "20fd08edee8f451198a5e24ea3f85ab0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/20fd08edee8f451198a5e24ea3f85ab0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/20fd08edee8f451198a5e24ea3f85ab0"}}, "title": "Economic arguments in migrant health policymaking: proposing a research agenda.", "authors": [{"family": "Gottlieb", "given": "Nora", "initials": "N"}, {"family": "Trummer", "given": "Ursula", "initials": "U"}, {"family": "Davidovitch", "given": "Nadav", "initials": "N"}, {"family": "Krasnik", "given": "Allan", "initials": "A"}, {"family": "Ju\u00e1rez", "given": "Sol P", "initials": "SP"}, {"family": "Rostila", "given": "Mikael", "initials": "M"}, {"family": "Biddle", "given": "Louise", "initials": "L"}, {"family": "Bozorgmehr", "given": "Kayvan", "initials": "K"}], "type": "letter", "published": "2020-11-20", "journal": {"title": "Global Health", "issn": "1744-8603", "volume": "16", "issue": "1", "pages": "113", "issn-l": "1744-8603"}, "abstract": "Welfare states around the world restrict access to public healthcare for some migrant groups. Formal restrictions on migrants' healthcare access are often justified with economic arguments; for example, as a means to prevent excess costs and safeguard scarce resources. However, existing studies on the economics of migrant health policies suggest that restrictive policies increase rather than decrease costs. This evidence has largely been ignored in migration debates. Amplifying the relationship between welfare state transformations and the production of inequalities, the Covid-19 pandemic may fuel exclusionary rhetoric and politics; or it may serve as an impetus to reconsider the costs that one group's exclusion from health can entail for all members of society.The public health community has a responsibility to promote evidence-informed health policies that are ethically and economically sound, and to counter anti-migrant and racial discrimination (whether overt or masked with economic reasoning). Toward this end, we propose a research agenda which includes 1) the generation of a comprehensive body of evidence on economic aspects of migrant health policies, 2) the clarification of the role of economic arguments in migration debates, 3) (self-)critical reflection on the ethics and politics of the production of economic evidence, 4) the introduction of evidence into migrant health policymaking processes, and 5) the endorsement of inter- and transdisciplinary approaches. With the Covid-19 pandemic and surrounding events rendering the suggested research agenda more topical than ever, we invite individuals and groups to join forces toward a (self-)critical examination of economic arguments in migration and health, and in public health generally.", "doi": "10.1186/s12992-020-00642-8", "pmid": "33218359", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12992-020-00642-8"}, {"db": "pmc", "key": "PMC7677743"}], "notes": [], "created": "2020-11-26T14:30:47.278Z", "modified": "2020-11-27T10:31:53.618Z"}, {"entity": "publication", "iuid": "b738ecb0902748d2b2458b462fd883cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b738ecb0902748d2b2458b462fd883cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b738ecb0902748d2b2458b462fd883cc"}}, "title": "The COVID-19 pandemic and global environmental change: Emerging research needs.", "authors": [{"family": "Barouki", "given": "Robert", "initials": "R"}, {"family": "Kogevinas", "given": "Manolis", "initials": "M"}, {"family": "Audouze", "given": "Karine", "initials": "K"}, {"family": "Belesova", "given": "Kristine", "initials": "K"}, {"family": "Bergman", "given": "Ake", "initials": "A"}, {"family": "Birnbaum", "given": "Linda", "initials": "L"}, {"family": "Boekhold", "given": "Sandra", "initials": "S"}, {"family": "Denys", "given": "Sebastien", "initials": "S"}, {"family": "Desseille", "given": "Celine", "initials": "C"}, {"family": "Drakvik", "given": "Elina", "initials": "E"}, {"family": "Frumkin", "given": "Howard", "initials": "H"}, {"family": "Garric", "given": "Jeanne", "initials": "J"}, {"family": "Destoumieux-Garzon", "given": "Delphine", "initials": "D"}, {"family": "Haines", "given": "Andrew", "initials": "A"}, {"family": "Huss", "given": "Anke", "initials": "A"}, {"family": "Jensen", "given": "Genon", "initials": "G"}, {"family": "Karakitsios", "given": "Spyros", "initials": "S"}, {"family": "Klanova", "given": "Jana", "initials": "J"}, {"family": "Koskela", "given": "Iida-Maria", "initials": "IM"}, {"family": "Laden", "given": "Francine", "initials": "F"}, {"family": "Marano", "given": "Francelyne", "initials": "F"}, {"family": "Franziska Matthies-Wiesler", "given": "Eva", "initials": "E"}, {"family": "Morris", "given": "George", "initials": "G"}, {"family": "Nowacki", "given": "Julia", "initials": "J"}, {"family": "Paloniemi", "given": "Riikka", "initials": "R"}, {"family": "Pearce", "given": "Neil", "initials": "N"}, {"family": "Peters", "given": "Annette", "initials": "A"}, {"family": "Rekola", "given": "Aino", "initials": "A"}, {"family": "Sarigiannis", "given": "Denis", "initials": "D"}, {"family": "\u0160ebkov\u00e1", "given": "Katerina", "initials": "K"}, {"family": "Slama", "given": "Remy", "initials": "R"}, {"family": "Staatsen", "given": "Brigit", "initials": "B"}, {"family": "Tonne", "given": "Cathryn", "initials": "C"}, {"family": "Vermeulen", "given": "Roel", "initials": "R"}, {"family": "Vineis", "given": "Paolo", "initials": "P"}, {"family": "HERA-COVID-19 working group. Electronic address: https://www.heraresearcheu.eu/", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-19", "journal": {"title": "Environ Int", "issn": "1873-6750", "volume": "146", "issue": null, "pages": "106272", "issn-l": "0160-4120"}, "abstract": "The outbreak of COVID-19 raised numerous questions on the interactions between the occurrence of new infections, the environment, climate and health. The European Union requested the H2020 HERA project which aims at setting priorities in research on environment, climate and health, to identify relevant research needs regarding Covid-19. The emergence and spread of SARS-CoV-2 appears to be related to urbanization, habitat destruction, live animal trade, intensive livestock farming and global travel. The contribution of climate and air pollution requires additional studies. Importantly, the severity of COVID-19 depends on the interactions between the viral infection, ageing and chronic diseases such as metabolic, respiratory and cardiovascular diseases and obesity which are themselves influenced by environmental stressors. The mechanisms of these interactions deserve additional scrutiny. Both the pandemic and the social response to the disease have elicited an array of behavioural and societal changes that may remain long after the pandemic and that may have long term health effects including on mental health. Recovery plans are currently being discussed or implemented and the environmental and health impacts of those plans are not clearly foreseen. Clearly, COVID-19 will have a long-lasting impact on the environmental health field and will open new research perspectives and policy needs.", "doi": "10.1016/j.envint.2020.106272", "pmid": "33238229", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0160-4120(20)32227-3"}, {"db": "pmc", "key": "PMC7674147"}], "notes": [], "created": "2020-11-27T10:27:55.912Z", "modified": "2020-11-30T07:44:55.359Z"}, {"entity": "publication", "iuid": "427a5f1f5bfb4a65a0ee29d88d1e1242", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/427a5f1f5bfb4a65a0ee29d88d1e1242.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/427a5f1f5bfb4a65a0ee29d88d1e1242"}}, "title": "Synthesis of Recommendations From 25 Countries and 31 Oncology Societies: How to Navigate Through Covid-19 Labyrinth.", "authors": [{"family": "Kamposioras", "given": "Konstantinos", "initials": "K"}, {"family": "Mauri", "given": "Davide", "initials": "D"}, {"family": "Papadimitriou", "given": "Konstantinos", "initials": "K"}, {"family": "Anthoney", "given": "Alan", "initials": "A"}, {"family": "Hindi", "given": "Nadia", "initials": "N"}, {"family": "Petricevic", "given": "Branka", "initials": "B"}, {"family": "Dambrosio", "given": "Mario", "initials": "M"}, {"family": "Valachis", "given": "Antonis", "initials": "A"}, {"family": "Kountourakis", "given": "Pantelis", "initials": "P"}, {"family": "Kopecky", "given": "Jindrich", "initials": "J"}, {"family": "Kuhar", "given": "Cvetka Gra\u0161i\u010d", "initials": "CG"}, {"family": "Popovic", "given": "Lazar", "initials": "L"}, {"family": "Chilingirova", "given": "Nataliya P", "initials": "NP"}, {"family": "Zarkavelis", "given": "George", "initials": "G"}, {"family": "de Mello", "given": "Ramon Andrade", "initials": "RA"}, {"family": "Plaveti\u0107", "given": "Natalija Dedi\u0107", "initials": "ND"}, {"family": "Christopoulos", "given": "Christos", "initials": "C"}, {"family": "Mostert", "given": "Bianca", "initials": "B"}, {"family": "Goffin", "given": "John R", "initials": "JR"}, {"family": "Tzachanis", "given": "Dimitiros", "initials": "D"}, {"family": "Saraireh", "given": "Haytham Hamed", "initials": "HH"}, {"family": "Ma", "given": "Fei", "initials": "F"}, {"family": "Pavese", "given": "Ida", "initials": "I"}, {"family": "Tolia", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2020-11-19", "journal": {"title": "Front Oncol", "issn": "2234-943X", "volume": "10", "issue": null, "pages": "575148", "issn-l": null}, "abstract": "Pandemic COVID-19 is an unexpected challenge for the oncological community, indicating potential detrimental effects on cancer patients. Our aim was to summarize the converging key points providing a general guidance in order to support decision making, pertaining to the oncologic care in the middle of a global outbreak.\n\nWe did an international online search in twenty five countries that have managed a surge in cancer patient numbers. We collected the recommendations from thirty one medical oncology societies.\n\nBy synthesizing guidelines for a) oncology service delivery adjustments, b) general and specific treatment adaptations, and c) discrepancies from guidelines comparison, we present a clinical synopsis with the forty more crucial statements. A Covid-19 risk stratification base was also created in order to obtain a quick, objective patient assessment and a risk-benefit evaluation on a case-by-case basis.\n\nIn an attempt to face these complex needs and due to limited understanding of COVID-19, a variability of recommendations based on general epidemiological and infectious disease principles rather than definite cancer-related evidence has evolved. Additionally, the absence of an effective treatment or vaccine requires the development of cancer management guidance, capitalizing on comprehensive COVID-19 oncology experience globally.", "doi": "10.3389/fonc.2020.575148", "pmid": "33330049", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7711151"}], "notes": [], "created": "2020-12-21T09:02:31.979Z", "modified": "2021-01-10T18:12:27.920Z"}, {"entity": "publication", "iuid": "edb87ec1c2214788a11083c24eca19c3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/edb87ec1c2214788a11083c24eca19c3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/edb87ec1c2214788a11083c24eca19c3"}}, "title": "Sleep Laboratories Reopening and COVID-19: A European Perspective.", "authors": [{"family": "Schiza", "given": "Sophia", "initials": "S"}, {"family": "Simonds", "given": "Anita", "initials": "A"}, {"family": "Randerath", "given": "Winfried", "initials": "W"}, {"family": "Fanfulla", "given": "Francesco", "initials": "F"}, {"family": "Testelmans", "given": "Dries", "initials": "D"}, {"family": "Grote", "given": "Ludger", "initials": "L"}, {"family": "Montserrat", "given": "Joseph M", "initials": "JM"}, {"family": "Pepin", "given": "Jean-Louis", "initials": "JL"}, {"family": "Verbracken", "given": "Johan", "initials": "J"}, {"family": "Ersu", "given": "Refika", "initials": "R"}, {"family": "Bonsignore", "given": "Maria R", "initials": "MR"}], "type": "journal article", "published": "2020-11-19", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "volume": null, "issue": null, "issn-l": "0903-1936"}, "abstract": "The clinical activities regarding sleep disordered breathing (SDB) have been sharply interrupted during the initial phase of the COVID-19 epidemic throughout Europe. In the last months, activities have gradually restarted, according to epidemiological phase of COVID-19 and National recommendations. The recent increase in cases throughout Europe obliges to reconsider management strategies of SDB accordingly. Diagnosis of SDB and initiation of treatment pose some specific problems to be addressed to preserve safety of the patients and health personnel. This perspective document by a group of European sleep experts aims at summarising some different approaches followed in Europe and United States, which reflect National recommendations according to the epidemiological phase of the COVID-19 infection. Respiratory sleep medicine will likely change in the near future, and use of telemedicine will grow to avoid unnecessary risks and continue to provide optimal care to the patients. The document also covers pediatric sleep studies and indications for titration of noninvasive ventilation, as well as precautions to be followed by patients who are already on positive airway pressure treatment. A single consensus document developed by the European Respiratory Society and National Societies would be desirable to harmonise SDB management throughout Europe.", "doi": "10.1183/13993003.02722-2020", "pmid": "33214202", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "13993003.02722-2020"}, {"db": "pmc", "key": "PMC7683791"}], "notes": [], "created": "2020-11-27T10:43:18.484Z", "modified": "2020-11-27T10:43:18.495Z"}, {"entity": "publication", "iuid": "f3b6d71139b14f2a8521373afff4ffaa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f3b6d71139b14f2a8521373afff4ffaa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f3b6d71139b14f2a8521373afff4ffaa"}}, "title": "Genetically proxied interleukin-6 receptor inhibition: opposing associations with COVID-19 and pneumonia.", "authors": [{"family": "Larsson", "given": "Susanna C", "initials": "SC"}, {"family": "Burgess", "given": "Stephen", "initials": "S"}, {"family": "Gill", "given": "Dipender", "initials": "D"}], "type": "letter", "published": "2020-11-19", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "issn-l": "0903-1936", "volume": "57", "issue": "1", "pages": null}, "abstract": null, "doi": "10.1183/13993003.03545-2020", "pmid": "33214204", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "13993003.03545-2020"}, {"db": "pmc", "key": "PMC7683792"}], "notes": [], "created": "2020-11-26T14:34:25.701Z", "modified": "2021-02-26T08:45:14.513Z"}, {"entity": "publication", "iuid": "1a27e0a50b4d4dfeb5ab4e7e90004286", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1a27e0a50b4d4dfeb5ab4e7e90004286.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1a27e0a50b4d4dfeb5ab4e7e90004286"}}, "title": "Brief Online Cognitive Behavioural Intervention for Dysfunctional Worry Related to the COVID-19 Pandemic: A Randomised Controlled Trial.", "authors": [{"family": "Wahlund", "given": "Tove", "initials": "T"}, {"family": "Mataix-Cols", "given": "David", "initials": "D"}, {"family": "Olofsdotter Lauri", "given": "Klara", "initials": "K"}, {"family": "de Schipper", "given": "Elles", "initials": "E"}, {"family": "Lj\u00f3tsson", "given": "Brj\u00e1nn", "initials": "B"}, {"family": "Aspvall", "given": "Kristina", "initials": "K"}, {"family": "Andersson", "given": "Erik", "initials": "E"}], "type": "journal article", "published": "2020-11-19", "journal": {"title": "Psychother Psychosom", "issn": "1423-0348", "issn-l": "0033-3190", "volume": null, "issue": null, "pages": "1-9"}, "abstract": "Worries about the immediate and long-term consequences of the COVID-19 pandemic may for some individuals develop into pervasive worry that is disproportionate in its intensity or duration and significantly interferes with everyday life.\r\n\r\nThe aim of this study was to investigate if a brief self-guided, online psychological intervention can reduce the degree of dysfunctional worry related to the COVID-19 pandemic and associated symptoms.\r\n\r\n670 adults from the Swedish general population reporting daily uncontrollable worry about CO-VID-19 and its possible consequences (e.g., illness, death, the economy, one's family) were randomised (1:1 ratio) to a 3-week self-guided, online cognitive behavioural intervention targeting dysfunctional COVID-19 worry and associated symptoms, or a waiting list of equal duration. The primary outcome measure was a COVID-19 adapted version of the Generalised Anxiety Disorder 7-item scale administered at baseline and weeks 1-3 (primary endpoint). Follow-up assessments were conducted 1 month after treatment completion. The trial was registered on ClinicalTrials.gov (NCT04341922) before inclusion of the first participant.\r\n\r\nThe main pre-specified intention-to-treat analysis indicated significant reductions in COVID-19-related worry for the intervention group compared to the waiting list (\u03b2 = 1.14, Z = 9.27, p < 0.001), corresponding to a medium effect size (bootstrapped d = 0.74 [95% CI: 0.58-0.90]). Improvements were also seen on all secondary measures, including mood, daily functioning, insomnia, and intolerance of uncertainty. Participant satisfaction was high. No serious adverse events were recorded.\r\n\r\nA brief digital and easily scalable self-guided psychological intervention can significantly reduce dysfunctional worry and associated behavioural symptoms related to the COVID-19 pandemic.", "doi": "10.1159/000512843", "pmid": "33212440", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "000512843"}, {"db": "ClinicalTrials.gov", "key": "NCT04341922"}], "notes": [], "created": "2020-11-27T09:45:47.728Z", "modified": "2021-02-26T08:46:59.845Z"}, {"entity": "publication", "iuid": "8da9a0a08cdf424ab35a2b5c1c3da037", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8da9a0a08cdf424ab35a2b5c1c3da037.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8da9a0a08cdf424ab35a2b5c1c3da037"}}, "title": "The known unknowns of T cell immunity to COVID-19.", "authors": [{"family": "Karlsson", "given": "Annika C", "initials": "AC", "orcid": "0000-0002-2028-8393", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9abf28110888427497db1e4abf6ff71d.json"}}, {"family": "Humbert", "given": "Marion", "initials": "M", "orcid": "0000-0002-1710-1479", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e43ab29ae76344aa83909afff892c6db.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}], "type": "journal article", "published": "2020-11-18", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "issn-l": "2470-9468", "volume": "5", "issue": "53", "pages": null}, "abstract": "Tremendous progress has been made in understanding the role of T cell immunity in acute and convalescent COVID-19 infection. Here we shed light on the \"known unknowns\" of pre-existing and acquired T cell responses in relation to acute and convalescent SARS-CoV-2 infection.", "doi": "10.1126/sciimmunol.abe8063", "pmid": "33208380", "labels": {"Type: Review": null, "Funder: VR": null}, "xrefs": [{"db": "pii", "key": "5/53/eabe8063"}], "notes": [], "created": "2020-11-27T09:49:11.516Z", "modified": "2023-06-19T14:56:20.106Z"}, {"entity": "publication", "iuid": "ab717979c71e46bbb7a827972b7a2835", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ab717979c71e46bbb7a827972b7a2835.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ab717979c71e46bbb7a827972b7a2835"}}, "title": "The impact of early public health interventions on SARS-CoV-2 transmission and evolution", "authors": [{"family": "Duchene", "given": "Sebastian", "initials": "S"}, {"family": "Featherstone", "given": "Leo", "initials": "L"}, {"family": "de Blasio", "given": "Birgitte Freiesleben", "initials": "BF"}, {"family": "Holmes", "given": "Edward C", "initials": "EC"}, {"family": "Bohlin", "given": "Jon", "initials": "J"}, {"family": "Pettersson", "given": "John H O", "initials": "JHO"}], "type": "posted-content", "published": "2020-11-18", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Many countries have attempted to control COVID-19 through the implementation of non-pharmaceutical interventions. However, it remains unclear how different control strategies have impacted SARS-CoV-2 virus transmission dynamics at the local level. Using complete SARS-CoV-2 genomes, we inferred the relative frequencies of virus importation and exportation, as well as virus transmission chain dynamics in Nordic countries - Denmark, Finland, Iceland, Norway and Sweden - during the first months of the pandemic. Our analyses revealed that Sweden experienced more numerous transmission chains, which tended to have more cases, and were of longer duration, a set of features that increased with time. Together with Denmark, Sweden was also a net exporter of SARS-CoV-2. Hence, Sweden effectively constituted an epidemiological and evolutionary \u2018refugia\u2019 that enabled the virus to maintain active transmission and spread to other geographic localities. This analysis highlights the utility of genomic surveillance where active transmission chain monitoring is a key metric.", "doi": "10.1101/2020.11.18.20233767", "pmid": null, "labels": {"Category: Genomics & transcriptomics": null, "Type: Preprint": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://www.medrxiv.org/content/medrxiv/early/2021/07/06/2020.11.18.20233767/DC1/embed/media-1.zip?download=true", "description": "Data available on GISAID, accession numbers found here (in the Supplementary Material)"}], "notes": [], "created": "2021-06-04T12:15:38.051Z", "modified": "2021-11-18T10:30:26.404Z"}, {"entity": "publication", "iuid": "03bef30654104a3da77bdc8ad1380279", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/03bef30654104a3da77bdc8ad1380279.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/03bef30654104a3da77bdc8ad1380279"}}, "title": "Misinformation, chiropractic, and the COVID-19 pandemic.", "authors": [{"family": "Ax\u00e9n", "given": "Iben", "initials": "I"}, {"family": "Bergstr\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Bronson", "given": "Marc", "initials": "M"}, {"family": "C\u00f4t\u00e9", "given": "Pierre", "initials": "P"}, {"family": "Nim", "given": "Casper Glissmann", "initials": "CG"}, {"family": "Goncalves", "given": "Guillaume", "initials": "G"}, {"family": "H\u00e9bert", "given": "Jeffrey J", "initials": "JJ"}, {"family": "Hertel", "given": "Joakim Axel", "initials": "JA"}, {"family": "Innes", "given": "Stanley", "initials": "S"}, {"family": "Larsen", "given": "Ole Kristoffer", "initials": "OK"}, {"family": "Meyer", "given": "Anne-Laure", "initials": "AL"}, {"family": "O'Neill", "given": "S\u00f8ren", "initials": "S"}, {"family": "Perle", "given": "Stephen M", "initials": "SM"}, {"family": "Weber", "given": "Kenneth A", "initials": "KA"}, {"family": "Young", "given": "Kenneth J", "initials": "KJ"}, {"family": "Leboeuf-Yde", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2020-11-18", "journal": {"title": "Chiropr Man Therap", "issn": "2045-709X", "volume": "28", "issue": "1", "pages": "65", "issn-l": "2045-709X"}, "abstract": "In March 2020, the World Health Organization elevated the coronavirus disease (COVID-19) epidemic to a pandemic and called for urgent and aggressive action worldwide. Public health experts have communicated clear and emphatic strategies to prevent the spread of COVID-19. Hygiene rules and social distancing practices have been implemented by entire populations, including 'stay-at-home' orders in many countries. The long-term health and economic consequences of the COVID-19 pandemic are not yet known.\n\nDuring this time of crisis, some chiropractors made claims on social media that chiropractic treatment can prevent or impact COVID-19. The rationale for these claims is that spinal manipulation can impact the nervous system and thus improve immunity. These beliefs often stem from nineteenth-century chiropractic concepts. We are aware of no clinically relevant scientific evidence to support such statements. We explored the internet and social media to collect examples of misinformation from Europe, North America, Australia and New Zealand regarding the impact of chiropractic treatment on immune function. We discuss the potential harm resulting from these claims and explore the role of chiropractors, teaching institutions, accrediting agencies, and legislative bodies.\n\nMembers of the chiropractic profession share a collective responsibility to act in the best interests of patients and public health. We hope that all chiropractic stakeholders will view the COVID-19 pandemic as a call to action to eliminate the unethical and potentially dangerous claims made by chiropractors who practise outside the boundaries of scientific evidence.", "doi": "10.1186/s12998-020-00353-2", "pmid": "33208144", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12998-020-00353-2"}, {"db": "pmc", "key": "PMC7672412"}], "notes": [], "created": "2020-11-26T12:36:03.161Z", "modified": "2020-11-27T09:51:10.068Z"}, {"entity": "publication", "iuid": "fda32fda6e5f47cd98b64d825f7259cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fda32fda6e5f47cd98b64d825f7259cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fda32fda6e5f47cd98b64d825f7259cb"}}, "title": "CETSA MS Profiling for a Comparative Assessment of FDA-Approved Antivirals Repurposed for COVID-19 Therapy Identifies TRIP13 as a Remdesivir Off-Target.", "authors": [{"family": "Friman", "given": "Tomas", "initials": "T"}, {"family": "Chernobrovkin", "given": "Alexey", "initials": "A"}, {"family": "Martinez Molina", "given": "Daniel", "initials": "D"}, {"family": "Arnold", "given": "Laurence", "initials": "L"}], "type": "journal article", "published": "2020-11-18", "journal": {"title": "SLAS Discov", "issn": "2472-5560", "issn-l": null, "volume": null, "issue": null, "pages": "2472555220973597"}, "abstract": "The reuse of preexisting small molecules for a novel emerging disease threat is a rapid measure to discover unknown applications for previously validated therapies. A pertinent and recent example where such a strategy could be employed is in the fight against coronavirus disease 2019 (COVID-19). Therapies designed or discovered to target viral proteins also have off-target effects on the host proteome when employed in a complex physiological environment. This study aims to assess these host cell targets for a panel of FDA-approved antiviral compounds including remdesivir, using the cellular thermal shift assay (CETSA) coupled with mass spectrometry (CETSA MS) in noninfected cells. CETSA MS is a powerful method to delineate direct and indirect interactions between small molecules and protein targets in intact cells. Biologically active compounds can induce changes in thermal stability, in their primary binding partners, and in proteins that in turn interact with the direct targets. Such engagement of host targets by antiviral drugs may contribute to the clinical effect against the virus but can also constitute a liability. We present here a comparative study of CETSA molecular target engagement fingerprints of antiviral drugs to better understand the link between off-targets and efficacy.", "doi": "10.1177/2472555220973597", "pmid": "33208020", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2020-11-30T16:12:53.941Z", "modified": "2021-02-26T08:45:25.950Z"}, {"entity": "publication", "iuid": "be13b13ee3b04c2288d72970f20ea3a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be13b13ee3b04c2288d72970f20ea3a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be13b13ee3b04c2288d72970f20ea3a2"}}, "title": "The limits of estimating COVID-19 intervention effects using Bayesian models", "authors": [{"family": "Elofsson", "given": "Arne", "initials": "A"}, {"family": "Bryant", "given": "Patrick", "initials": "P"}], "type": "posted-content", "published": "2020-11-17", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To limit the rapid spread of COVID-19, most governments have introduced different non-pharmaceutical interventions, which might have severe costs for society. Therefore, it is crucial to evaluate the most cost-effective interventions, using, for instance, Bayesian modelling. Such modelling efforts have deemed lockdown to account for 81% of the reduction in R0, contributing to government policies. Here, we show that these conclusions are unsupported and that policies therefore should not be based on these studies.", "doi": "10.1101/2020.08.14.20175240", "pmid": null, "labels": {"Funder: VR": null, "Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-17T13:25:54.970Z", "modified": "2021-02-26T08:45:48.630Z"}, {"entity": "publication", "iuid": "a9a372ecfb2043dcbeb9484cacd0b451", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a9a372ecfb2043dcbeb9484cacd0b451.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a9a372ecfb2043dcbeb9484cacd0b451"}}, "title": "The effect of opening up the US on COVID-19 spread", "authors": [{"family": "Elofsson", "given": "Arne", "initials": "A"}, {"family": "Bryant", "given": "Patrick", "initials": "P"}], "type": null, "published": "2020-11-17", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "In response to the pandemic development of the novel coronavirus (SARS-CoV-2), governments worldwide have implemented strategies of suppression by non-pharmaceutical interventions (NPIs). Such NPIs include social distancing, school closures, limiting international travel and complete lockdown. Worldwide the NPIs enforced to limit the spread of COVID-19 are now being lifted. Understanding how the risk increases when NPIs are lifted is important for decision making. Treating NPIs equally across countries and regions limits the possibility for modelling differences in epidemic response, as the response to the NPIs influences can vary between regions and this can affect the epidemic outcome, so do the strength and speed of lifting these. Our solution to this is to measure mobility changes from mobile phone data and their impacts on the basic reproductive number. We model the epidemic in all US states to compare the difference in outcome if NPIs are lifted or retained. We show that keeping NPIs just a few weeks longer has a substantial impact on the epidemic outcome.", "doi": "10.1101/2020.07.03.20145649", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "URL", "key": "https://github.com/patrickbryant1/COVID19.github.io/tree/master/simulations/mobility/dev/US", "description": "Analysis code and data"}], "notes": [], "created": "2020-11-17T13:20:52.223Z", "modified": "2022-11-09T08:20:04.453Z"}, {"entity": "publication", "iuid": "7ca4e69b988a427d86f38d90955b2c7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7ca4e69b988a427d86f38d90955b2c7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7ca4e69b988a427d86f38d90955b2c7e"}}, "title": "Perturbations in the mononuclear phagocyte landscape associated with COVID-19 disease severity", "authors": [{"family": "Kvedaraite", "given": "Egle", "initials": "E"}, {"family": "Hertwig", "given": "Laura", "initials": "L"}, {"family": "Indranil", "given": "Sinha", "initials": "S"}, {"family": "Ponzetta", "given": "Andrea", "initials": "A"}, {"family": "Hed Myrberg", "given": "Ida", "initials": "I"}, {"family": "Magdalini Lourda", "given": "M", "initials": "M"}, {"family": "Dzidic", "given": "Majda", "initials": "M"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Klingstrom", "given": "Jonas", "initials": "J"}, {"family": "Folkesson", "given": "Elin", "initials": "E"}, {"family": "Muvva", "given": "Rao", "initials": "R"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Brighenti", "given": "Susanna", "initials": "S"}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A"}, {"family": "Lars I. Eriksson", "given": "Lars I.", "initials": "LI"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Stralin", "given": "Krustoffer", "initials": "K"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Ginhoux", "given": "Florent", "initials": "F"}, {"family": "Bjorkstrom", "given": "Niclas", "initials": "N"}, {"family": "Henter", "given": "Jan-Inge", "initials": "J"}, {"family": "Svensson", "given": "Mattias", "initials": "M"}], "type": "journal article", "published": "2020-11-17", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "issn-l": "0027-8424", "volume": "118", "issue": "6", "pages": null}, "abstract": "Monocytes and dendritic cells are crucial mediators of innate and adaptive immune responses during viral infection, but misdirected responses by these cells might contribute to immunopathology. A comprehensive map of the mononuclear phagocyte (MNP) landscape during SARS-CoV-2 infection and concomitant COVID-19 disease is lacking. We performed 25-color flow cytometry-analysis focusing on MNP lineages in SARS-CoV-2 infected patients with moderate and severe COVID-19. While redistribution of monocytes towards intermediate subset and decrease in circulating DCs occurred in response to infection, severe disease associated with appearance of Mo-MDSC-like cells and a higher frequency of pre-DC2. Furthermore, phenotypic alterations in MNPs, and their late precursors, were cell-lineage specific and in select cases associated with severe disease. Finally, unsupervised analysis revealed that the MNP profile, alone, could identify a cluster of COVID-19 non-survivors. This study provides a reference for the MNP response to clinical SARS-CoV-2 infection and unravel myeloid dysregulation associated with severe COVID-19.", "doi": "10.1073/pnas.2018587118", "pmid": "33479167", "labels": {"Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null, "Funder: Vinnova": null, "Funder: VR": null, "Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-17T17:34:32.059Z", "modified": "2021-06-13T14:15:44.123Z"}, {"entity": "publication", "iuid": "19520c0d2e594922b47369a93ce61cb0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19520c0d2e594922b47369a93ce61cb0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19520c0d2e594922b47369a93ce61cb0"}}, "title": "Outcome prediction by serum calprotectin in patients with COVID-19 in the emergency department.", "authors": [{"family": "Bauer", "given": "Wolfgang", "initials": "W"}, {"family": "Diehl-Wiesenecker", "given": "Eva", "initials": "E"}, {"family": "Ulke", "given": "Jannis", "initials": "J"}, {"family": "Galtung", "given": "Noa", "initials": "N"}, {"family": "Havelka", "given": "Aleksandra", "initials": "A"}, {"family": "Hegel", "given": "J Kolja", "initials": "JK"}, {"family": "Tauber", "given": "Rudolf", "initials": "R"}, {"family": "Somasundaram", "given": "Rajan", "initials": "R"}, {"family": "Kappert", "given": "Kai", "initials": "K"}], "type": "letter", "published": "2020-11-17", "journal": {"title": "J Infect", "issn": "1532-2742", "volume": null, "issue": null, "issn-l": "0163-4453"}, "abstract": null, "doi": "10.1016/j.jinf.2020.11.016", "pmid": "33217473", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S0163-4453(20)30711-8"}, {"db": "pmc", "key": "PMC7670934"}], "notes": [], "created": "2020-11-26T14:31:48.547Z", "modified": "2021-02-26T08:45:02.871Z"}, {"entity": "publication", "iuid": "9ca4b2c8bb234e6aaec0b39b03ce25c2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ca4b2c8bb234e6aaec0b39b03ce25c2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ca4b2c8bb234e6aaec0b39b03ce25c2"}}, "title": "Outcome of COVID-19 in multiple myeloma patients in relation to treatment.", "authors": [{"family": "Susek", "given": "K. H.,", "initials": "KH"}, {"family": "Gran", "given": "C.,", "initials": "C"}, {"family": "Ljunggren", "given": "H. G.,", "initials": "HG"}, {"family": "Alici", "given": "E.,", "initials": "E"}, {"family": "Nahi", "given": "H.", "initials": "H"}], "type": null, "published": "2020-11-17", "journal": {"title": "Eur J Haematol.", "issn": null, "issn-l": null, "volume": "105", "issue": "6", "pages": "751-754"}, "abstract": "COVID\u201019 has emerged as a global pandemic. Cancer patients have been reported to be at higher risk for adverse outcome of COVID\u201019. Studies are ongoing to decipher the risk factors and risk groups among cancer patients as well as strategies to refine treatment approaches. Here, we report eight patients with multiple myeloma that underwent immunomodulatory therapies with daratumumab or lenalidomide\u2010based combination treatments and one patient with smoldering multiple myeloma, all of which presented with symptomatic COVID\u201019. We report that patients that succumbed to COVID\u201019 presented with either progressive tumor disease under daratumumab treatment or were in remission under lenalidomide\u2010dexamethasone treatment.", "doi": "10.1111/ejh.13502", "pmid": null, "labels": {"Type: Journal article": null, "Funder: Vinnova": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Provided in the article: Characteristics, treatments, COVID-19-related outcomes, additional laboratory and clinical data for 9 patients", "description": null}], "notes": [], "created": "2020-11-04T16:20:40.991Z", "modified": "2021-02-26T08:45:48.516Z"}, {"entity": "publication", "iuid": "5c098e68a7284bf4bc17ae331fd69552", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5c098e68a7284bf4bc17ae331fd69552.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5c098e68a7284bf4bc17ae331fd69552"}}, "title": "Modelling the dispersion of SARS-CoV-2 on a dynamic network graph", "authors": [{"family": "Elofsson", "given": "Arne", "initials": "A"}, {"family": "Bryant", "given": "Patrick", "initials": "P"}], "type": null, "published": "2020-11-17", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Background When modelling the dispersion of an epidemic using R0, one only considers the average number of individuals each infected individual will infect. However, we know from extensive studies of social networks that there is significant variation in the number of connections and thus social contacts each individual has. Individuals with more social contacts are more likely to attract and spread infection. These individuals are likely the drivers of the epidemic, so-called superspreaders. When many superspreaders are immune, it becomes more difficult for the disease to spread, as the connectedness of the social network dramatically decreases. If one assumes all individuals being equally connected and thus as likely to spread disease as in a SIR model, this is not true.\r\n\r\nMethods To account for the impact of social network structure on epidemic development, we model the dispersion of SARS-CoV-2 on a dynamic preferential attachment graph which changes appearance proportional to observed mobility changes. We sample a serial interval distribution that determines the probability of dispersion for all infected nodes each day. We model the dispersion in different age groups using age-specific infection fatality rates. We vary the infection probabilities in different age groups and analyse the outcome.\r\n\r\nResults The impact of movement on network dynamics plays a crucial role in the spread of infections. We find that higher movement results in higher spread due to an increased probability of new connections being made within a social network. We show that saturation in the dispersion can be reached much earlier on a preferential attachment graph compared to spread on a random graph, which is more similar to estimations using R0.\r\n\r\nConclusions We provide a novel method for modelling epidemics by using a dynamic network structure related to observed mobility changes. The social network structure plays a crucial role in epidemic development, something that is often overlooked.", "doi": "10.1101/2020.10.19.20215046", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Genomics & transcriptomics": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "URL", "key": "https://github.com/patrickbryant1/epidemic_net", "description": "Code, data, and results related to modelling the spread of COVID-19 on a dynamic social network with spread reduction according to Google mobility changes"}], "notes": [], "created": "2020-11-17T13:24:02.281Z", "modified": "2022-11-09T08:21:07.257Z"}, {"entity": "publication", "iuid": "bb13de8cbe1a40c4890b291266d4ec34", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb13de8cbe1a40c4890b291266d4ec34.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb13de8cbe1a40c4890b291266d4ec34"}}, "title": "Global analysis of more than 50,000 SARS-CoV-2 genomes reveals epistasis between eight viral genes", "authors": [{"family": "Zeng", "given": "Hong Li", "initials": "HL"}, {"family": "Dichio", "given": "Vito", "initials": "V"}, {"family": "Rodr\u00edguez Horta", "given": "Edwin", "initials": "E"}, {"family": "Thorell", "given": "Kaisa", "initials": "K"}, {"family": "Aurell", "given": "Erik", "initials": "E"}], "type": "journal-article", "published": "2020-11-17", "journal": {"title": "Proc Natl Acad Sci USA", "issn": "0027-8424", "issn-l": "0027-8424", "volume": null, "issue": null, "pages": "202012331"}, "abstract": null, "doi": "10.1073/pnas.2012331117", "pmid": null, "labels": {"Type: Journal article": null, "Funder: H2020": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "URL", "key": "https://www.pnas.org/content/117/49/31519#sec-14", "description": "Data is included in the article and supplementary information"}], "notes": [], "created": "2020-11-18T10:56:55.452Z", "modified": "2021-11-18T10:22:35.025Z"}, {"entity": "publication", "iuid": "c2f01753f5bb4ec59ebe3c6b8efa29ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c2f01753f5bb4ec59ebe3c6b8efa29ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c2f01753f5bb4ec59ebe3c6b8efa29ca"}}, "title": "Case report and systematic review suggest that children may experience similar long-term effects to adults after clinical COVID-19.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "journal article", "published": "2020-11-17", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "volume": null, "issue": null, "issn-l": null}, "abstract": "Persistent symptoms in adults after COVID-19 are emerging and the term long COVID is increasingly appearing in the literature. However, paediatric data are scarce .\n\nThis paper contains a case report of five Swedish children and the long-term symptoms reported by their parents. It also includes a systematic literature review of the MEDLINE, EMBASE and Web of Science databases and the medRxiv/bioRxiv preprint servers up to 2 November 2020.\n\nThe five children with potential long covid had a median age of 12 years (range 9-15) and four were girls. They had symptoms for 6-8 months after their clinical diagnoses of COVID-19. None were hospitalised at diagnosis, but one was later admitted for peri-myocarditis. All five children had fatigue, dyspnoea, heart palpitations or chest pain and four had headaches, difficulties concentrating, muscle weakness, dizziness and sore throats. Some had improved after 6-8 months, but they all suffered from fatigue and none had fully returned to school. The systematic review identified 179 publications and 19 of these were deemed relevant and read in detail. None contained any information on long COVID in children.\n\nChildren may experience similar long COVID symptoms to adults and females may be more affected.", "doi": "10.1111/apa.15673", "pmid": "33205450", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Provided in the article: clinical data reported by parents of five children with long-term effects of COVID-19", "description": null}], "notes": [], "created": "2020-11-26T12:26:47.588Z", "modified": "2021-02-26T08:45:48.669Z"}, {"entity": "publication", "iuid": "fb3edae98f5e4ab289309ee5f0d9bba6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb3edae98f5e4ab289309ee5f0d9bba6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb3edae98f5e4ab289309ee5f0d9bba6"}}, "title": "A complicated way of boiling water: nuclear safety in water history.", "authors": [{"family": "Evens", "given": "Siegfried", "initials": "S"}], "type": "journal article", "published": "2020-11-17", "journal": {"title": "Water Hist", "issn": "1877-7236", "volume": null, "issue": null, "pages": "1-14", "issn-l": null}, "abstract": "Water and nuclear reactors are much closer intertwined than usually perceived. First, water is the source of the steam that drives the turbines of most nuclear power plants around the world. Next to generating electricity, water is the key to preventing accidents in nuclear plants. As uranium keeps on generating heat when the power plant is turned off, its core needs to be cooled continuously. This crucial connection between water and nuclear is focus of the paper. Nuclear safety will appear as relying heavily on earlier knowledge, institutions, and regulatory frameworks, which were related to water. The three parts of this article discuss technologies, actors and risks of nuclear power. Studying water as a resource in a much broader sense than being boiled for steam shows how determining water is to make nuclear power function. As this paper is part of a special issue, Water History in the time of COVID-19, it has undergone modified peer review.", "doi": "10.1007/s12685-020-00258-0", "pmid": "33224318", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "258"}, {"db": "pmc", "key": "PMC7671176"}], "notes": [], "created": "2020-11-27T10:30:21.178Z", "modified": "2020-11-27T10:30:21.198Z"}, {"entity": "publication", "iuid": "b4ad408a15f543c599c0cb75863ae60d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b4ad408a15f543c599c0cb75863ae60d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b4ad408a15f543c599c0cb75863ae60d"}}, "title": "Mitigating COVID-19 Impact on the Portuguese Population Mental Health: The Opportunity That Lies in Digital Mental Health.", "authors": [{"family": "Mendes-Santos", "given": "Cristina", "initials": "C"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Weiderpass", "given": "Elisabete", "initials": "E"}, {"family": "Santana", "given": "Rui", "initials": "R"}], "type": "journal article", "published": "2020-11-16", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "553345", "issn-l": "2296-2565"}, "abstract": "COVID-19 mitigation measures present unprecedented challenges in mental healthcare delivery, posing high risk to the mental health of at-risk populations, namely patients diagnosed with COVID-19, frontline healthcare providers, and those submitted to quarantine or isolation measures, as well as the general population. Ensuring safe and equitable access to mental healthcare by these groups entails resorting to innovative psychosocial intervention strategies, such as digital mental health. In this perspective piece, we describe the impact of COVID-19 on the Portuguese population's mental health, present an overview on initiatives developed to address the challenges currently faced by the Portuguese mental healthcare system, and discuss how the timely implementation of a comprehensive digital mental health strategy, coupling research, education, implementation, and quality assessment initiatives, might buffer COVID-19's impact on the Portuguese society.", "doi": "10.3389/fpubh.2020.553345", "pmid": "33313033", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7701327"}], "notes": [], "created": "2020-12-21T10:17:55.193Z", "modified": "2021-02-26T08:47:00.167Z"}, {"entity": "publication", "iuid": "300659f5bed046a18cd1b58ab66f9644", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/300659f5bed046a18cd1b58ab66f9644.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/300659f5bed046a18cd1b58ab66f9644"}}, "title": "International Study of Movement Behaviors in the Early Years (SUNRISE): Results from SUNRISE Sweden's Pilot and COVID-19 Study.", "authors": [{"family": "Delisle Nystr\u00f6m", "given": "Christine", "initials": "C"}, {"family": "Alexandrou", "given": "Christina", "initials": "C"}, {"family": "Henstr\u00f6m", "given": "Maria", "initials": "M"}, {"family": "Nilsson", "given": "Ellinor", "initials": "E"}, {"family": "Okely", "given": "Anthony D", "initials": "AD"}, {"family": "Wehbe El Masri", "given": "Serina", "initials": "S"}, {"family": "L\u00f6f", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2020-11-16", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "22", "pages": null}, "abstract": "The International Study of Movement Behaviors in the Early Years (SUNRISE) was initiated in response to the 2019 WHO guidelines for physical activity, sedentary behavior, and sleep in children aged 0-5 years. This Swedish pilot study aimed to: (i) assess the proportion of preschoolers meeting the guidelines, (ii) evaluate the feasibility of the methods for the SUNRISE study, and (iii) assess how movement behaviors have been affected in preschoolers during the COVID-19 pandemic. Physical activity and sleep (waist-worn ActiGraph); screen time and movement behaviors (parental questionnaire); motor skills (Ages and Stages Questionnaire); and executive functions (3 iPad games) were assessed in 100 Swedish preschoolers ( n = 58 boys). There were 19.4% of preschoolers (n = 14) who met the WHO guidelines. The motor skill and executive function assessments were feasible; however, 20% refused to wear the ActiGraph overnight. Additionally, during the pandemic Swedish children's physical activity, time spent outside on weekdays and weekend days, and screen time significantly increased (+53; +124; +68; +30min/day, respectively, all p-values \u2264 0.001). Methods for the SUNRISE study were feasible in a Swedish context; however, considerations to switch to a wrist-worn accelerometer should be made. Furthermore, children's physical activity increased during the pandemic, which is likely due to how the rules/restrictions were implemented in Sweden.", "doi": "10.3390/ijerph17228491", "pmid": "33207786", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "ijerph17228491"}], "notes": [], "created": "2020-11-27T09:52:00.784Z", "modified": "2022-11-09T08:22:22.764Z"}, {"entity": "publication", "iuid": "0d51904ea0864a848c8ab3a0f232cc54", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d51904ea0864a848c8ab3a0f232cc54.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d51904ea0864a848c8ab3a0f232cc54"}}, "title": "COVID-19 patients in intensive care develop predominantly oliguric acute kidney injury.", "authors": [{"family": "Luther", "given": "Tomas", "initials": "T"}, {"family": "B\u00fclow-Anderberg", "given": "Sara", "initials": "S"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Rubertsson", "given": "Sten", "initials": "S"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2020-11-15", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": "65", "issue": "3", "pages": "364-372"}, "abstract": "Acute kidney injury (AKI) is a syndrome of reduced glomerular filtration rate and/or reduced urine flow associated with mortality in corona virus disease 2019 (COVID-19). AKI is often associated with renal tissue damage, which may lead to chronic kidney disease. Biomarkers of tissue damage may identify patients of particular risk.\r\n\r\nIn a prospective observational study of 57 patients admitted to intensive care, AKI incidence and characteristics was evaluated according to KDIGO criteria and related to days after admission. Urinary albumin, Neutrophil Gelatinase-Associated Lipocalin (NGAL), Kidney Injury Molecule 1 (KIM-1) and Plasma Tissue Inhibitor of MetalloProteinase 2 (TIMP-2) were analysed in 52 patients at admission. The majority (n = 51, 89%) of patients developed AKI, and 27 (47%) patients had predominantly oliguric AKI where oliguria was more severe than plasma Creatinine increase. Severe oliguria within first 2 days after admission was common (n = 37, 65%), whereas stage 2 and 3 AKI due to Creatinine occurred later than day 2 in 67% (12/18) of cases. Renal replacement therapy was started in 9 (16%) patients, and 30-day mortality was 28%. Urinary biomarkers were increased in a majority of patients, but did not robustly predict KDIGO stage. Most patients had microalbuminuria, and severe albuminuria (albumin Creatinine ratio > 30 mg/mmol) was found in n = 9 (17%) patients.\r\n\r\nA majority of patients with COVID-19 admitted to the ICU develop AKI. The functional deficit is often low urinary volume, and initial levels of biomarkers are generally increased without clear relation to final AKI stage.", "doi": "10.1111/aas.13746", "pmid": "33190222", "labels": {"Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT04316884", "description": null}], "notes": [], "created": "2020-11-30T16:21:03.364Z", "modified": "2021-06-13T14:16:05.611Z"}, {"entity": "publication", "iuid": "80604ed113e244199546e41b2aaeb597", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/80604ed113e244199546e41b2aaeb597.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/80604ed113e244199546e41b2aaeb597"}}, "title": "Progress report on new antiepileptic drugs: A summary of the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV). I. Drugs in preclinical and early clinical development.", "authors": [{"family": "Bialer", "given": "Meir", "initials": "M"}, {"family": "Johannessen", "given": "Svein I", "initials": "SI"}, {"family": "Koepp", "given": "Matthias J", "initials": "MJ"}, {"family": "Levy", "given": "Ren\u00e9 H", "initials": "RH"}, {"family": "Perucca", "given": "Emilio", "initials": "E"}, {"family": "Perucca", "given": "Piero", "initials": "P"}, {"family": "Tomson", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "White", "given": "H Steve", "initials": "HS"}], "type": "journal article", "published": "2020-11-14", "journal": {"title": "Epilepsia", "issn": "1528-1167", "volume": null, "issue": null, "pages": null, "issn-l": "0013-9580"}, "abstract": "Since 1992, the Eilat Conferences have provided a forum for all stakeholders in the epilepsy community to appraise the latest data on new antiepileptic drugs and emergency seizure treatments, including, in recent years, updates on progress with the development of novel monitoring and therapeutic devices. Because of the COVID-19 pandemic, the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV) was held as a fully virtual conference on July 27-30, 2020 for the sessions on drugs and on August 3, 2020 for the sessions on devices, and was attended during the 5 days by >500 participants from 63 countries. This progress report summarizes key preclinical and initial (phase 1) clinical data on eight investigational treatments that are currently in early development, including 2-deoxy-D-glucose, GAO-3-02, JNJ-40411813, NBI-921352, NTX-001, sec-butylpropylacetamide, XEN1101, and XEN496. This report provides an overview of current scenarios in the area of treatment discovery and development. The information presented illustrates a variety of innovative strategies, including exploration of compounds with novel mechanisms of action, transplantation of interneurons into epileptogenic brain regions, and the targeting of rare, previously neglected syndromes.", "doi": "10.1111/epi.16725", "pmid": "33190243", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-27T09:56:44.967Z", "modified": "2020-11-27T09:57:08.067Z"}, {"entity": "publication", "iuid": "098e78feb6644af587ed79f4227ad801", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/098e78feb6644af587ed79f4227ad801.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/098e78feb6644af587ed79f4227ad801"}}, "title": "Mortality in Norway and Sweden before and after the Covid-19 outbreak: a cohort study", "authors": [{"family": "Juul", "given": "Frederik E", "initials": "FE"}, {"family": "Jodal", "given": "Henriette C", "initials": "HC"}, {"family": "Barua", "given": "Ishita", "initials": "I"}, {"family": "Refsum", "given": "Erle", "initials": "E"}, {"family": "Olsvik", "given": "\u00d8rjan", "initials": "\u00d8"}, {"family": "Helsingen", "given": "Lise M", "initials": "LM"}, {"family": "L\u00f8berg", "given": "Magnus", "initials": "M"}, {"family": "Bretthauer", "given": "Michael", "initials": "M"}, {"family": "Kalager", "given": "Mette", "initials": "M"}, {"family": "Emilsson", "given": "Louise", "initials": "L"}], "type": "posted-content", "published": "2020-11-13", "journal": {"title": "", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.11.11.20229708", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-10T04:25:00.880Z", "modified": "2021-06-10T04:25:46.265Z"}, {"entity": "publication", "iuid": "7c3d20509f2741158f4b2fd57038223d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7c3d20509f2741158f4b2fd57038223d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7c3d20509f2741158f4b2fd57038223d"}}, "title": "JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality.", "authors": [{"family": "Stebbing", "given": "Justin", "initials": "J"}, {"family": "S\u00e1nchez Nievas", "given": "Gin\u00e9s", "initials": "G"}, {"family": "Falcone", "given": "Marco", "initials": "M"}, {"family": "Youhanna", "given": "Sonia", "initials": "S"}, {"family": "Richardson", "given": "Peter", "initials": "P"}, {"family": "Ottaviani", "given": "Silvia", "initials": "S"}, {"family": "Shen", "given": "Joanne X", "initials": "JX"}, {"family": "Sommerauer", "given": "Christian", "initials": "C"}, {"family": "Tiseo", "given": "Giusy", "initials": "G"}, {"family": "Ghiadoni", "given": "Lorenzo", "initials": "L"}, {"family": "Virdis", "given": "Agostino", "initials": "A"}, {"family": "Monzani", "given": "Fabio", "initials": "F"}, {"family": "Rizos", "given": "Luis Romero", "initials": "LR"}, {"family": "Forfori", "given": "Francesco", "initials": "F"}, {"family": "Avenda\u00f1o-C\u00e9spedes", "given": "Almudena", "initials": "A"}, {"family": "De Marco", "given": "Salvatore", "initials": "S"}, {"family": "Carrozzi", "given": "Laura", "initials": "L"}, {"family": "Lena", "given": "Fabio", "initials": "F"}, {"family": "S\u00e1nchez-Jurado", "given": "Pedro Manuel", "initials": "PM"}, {"family": "Lacerenza", "given": "Leonardo Gianluca", "initials": "LG"}, {"family": "Cesira", "given": "Nencioni", "initials": "N"}, {"family": "Caldevilla-Bernardo", "given": "David", "initials": "D"}, {"family": "Perrella", "given": "Antonio", "initials": "A"}, {"family": "Niccoli", "given": "Laura", "initials": "L"}, {"family": "M\u00e9ndez", "given": "Lourdes S\u00e1ez", "initials": "LS"}, {"family": "Matarrese", "given": "Daniela", "initials": "D"}, {"family": "Goletti", "given": "Delia", "initials": "D"}, {"family": "Tan", "given": "Yee-Joo", "initials": "Y"}, {"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Dranitsaris", "given": "George", "initials": "G"}, {"family": "Cantini", "given": "Fabrizio", "initials": "F"}, {"family": "Farcomeni", "given": "Alessio", "initials": "A"}, {"family": "Dutta", "given": "Shuchismita", "initials": "S"}, {"family": "Burley", "given": "Stephen K", "initials": "SK"}, {"family": "Zhang", "given": "Haibo", "initials": "H"}, {"family": "Pistello", "given": "Mauro", "initials": "M"}, {"family": "Li", "given": "William", "initials": "W"}, {"family": "Mas Romero", "given": "Marta", "initials": "M"}, {"family": "Andr\u00e9s Pretel", "given": "Fernando", "initials": "F"}, {"family": "Sim\u00f3n-Talero", "given": "Rafaela S\u00e1nchez", "initials": "RS"}, {"family": "Garc\u00eda-Molina", "given": "Rafael", "initials": "R"}, {"family": "Kutter", "given": "Claudia", "initials": "C"}, {"family": "Felce", "given": "James H", "initials": "JH"}, {"family": "Nizami", "given": "Zehra F", "initials": "ZF"}, {"family": "Miklosi", "given": "Andras G", "initials": "AG"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}, {"family": "Menichetti", "given": "Francesco", "initials": "F"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Abizanda", "given": "Pedro", "initials": "P"}, {"family": "Lauschke", "given": "Volker M", "initials": "VM"}], "type": "journal article", "published": "2020-11-13", "journal": {"title": "Sci Adv", "issn": "2375-2548", "issn-l": "2375-2548", "volume": "7", "issue": "1", "pages": null}, "abstract": "Using AI we identified baricitinib as possessing anti-viral and anti-cytokine efficacy. We now show a 71% (95% CI 0.15-0.58) mortality benefit in 83 patients with moderate-severe SARS-CoV-2 pneumonia with few drug-induced adverse events, including a large elderly cohort (median age 81 years). A further 48 cases with mild-moderate pneumonia recovered uneventfully. Using organotypic 3D cultures of primary human liver cells, we demonstrate that interferon-alpha-2 (IFN\u03b12) significantly increases ACE2 expression and SARS-CoV-2 infectivity in parenchymal cells by >5-fold. RNA-Seq reveals gene response signatures associated with platelet activation, fully inhibited by baricitinib. Using viral load quantifications and super-resolution microscopy, baricitinib exerts activity rapidly through the inhibition of host proteins (numb associated kinases), uniquely amongst anti-virals. This reveals mechanistic actions of a Janus kinase-1/2 inhibitor targeting viral entry, replication and the cytokine storm, and is associated with beneficial outcomes including in severely ill elderly patients, data that incentivizes further randomized controlled trials.", "doi": "10.1126/sciadv.abe4724", "pmid": "33187978", "labels": {"Type: Journal article": null, "Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-9711/", "description": "Array Express E-MTAB-9711: RNA-seq of SARS-CoV-2-infected human primary hepatocyte-derived spheroids upon interferon a2 and baricitinib treatment"}, {"db": "URL", "key": "http://advances.sciencemag.org/cgi/content/full/sciadv.abe4724/DC1", "description": "Supplementary information"}], "notes": [], "created": "2020-11-18T15:27:10.197Z", "modified": "2021-06-13T14:16:56.042Z"}, {"entity": "publication", "iuid": "ea3e7e32fe0a47af92fac82feeace707", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ea3e7e32fe0a47af92fac82feeace707.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ea3e7e32fe0a47af92fac82feeace707"}}, "title": "The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19.", "authors": [{"family": "Consiglio", "given": "Camila Rosat", "initials": "CR", "orcid": "0000-0002-8901-2328", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/583a255a08b64095b9c4642911e1a922.json"}}, {"family": "Cotugno", "given": "Nicola", "initials": "N", "orcid": "0000-0002-7748-1581", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7e39b95146ec4289b4efd91f869e2853.json"}}, {"family": "Sardh", "given": "Fabian", "initials": "F"}, {"family": "Pou", "given": "Christian", "initials": "C"}, {"family": "Amodio", "given": "Donato", "initials": "D", "orcid": "0000-0003-4550-3018", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8036babccffd453ab3dda55c13a204fa.json"}}, {"family": "Rodriguez", "given": "Lucie", "initials": "L", "orcid": "0000-0002-3692-9060", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47b10420d4f449929ff0221bf881c7c4.json"}}, {"family": "Tan", "given": "Ziyang", "initials": "Z"}, {"family": "Zicari", "given": "Sonia", "initials": "S", "orcid": "0000-0003-1240-8057", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0379fd354fd3492aa5d5fe8ea9e16065.json"}}, {"family": "Ruggiero", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-1041-7489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e47b6216d0514a37818f676dce75ff57.json"}}, {"family": "Pascucci", "given": "Giuseppe Rubens", "initials": "GR", "orcid": "0000-0002-5978-1193", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cfa33536b1242949e2195412e11f541.json"}}, {"family": "Santilli", "given": "Veronica", "initials": "V"}, {"family": "Campbell", "given": "Tessa", "initials": "T"}, {"family": "Bryceson", "given": "Yenan", "initials": "Y"}, {"family": "Eriksson", "given": "Daniel", "initials": "D"}, {"family": "Wang", "given": "Jun", "initials": "J"}, {"family": "Marchesi", "given": "Alessandra", "initials": "A"}, {"family": "Lakshmikanth", "given": "Tadepally", "initials": "T", "orcid": "0000-0001-7256-5770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a119d704e3594d66ae78021072a8f9ba.json"}}, {"family": "Campana", "given": "Andrea", "initials": "A"}, {"family": "Villani", "given": "Alberto", "initials": "A", "orcid": "0000-0002-9120-0424", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5005156054ed4498b7d938cbb7caf42e.json"}}, {"family": "Rossi", "given": "Paolo", "initials": "P"}, {"family": "CACTUS Study Team", "given": "", "initials": ""}, {"family": "Landegren", "given": "Nils", "initials": "N"}, {"family": "Palma", "given": "Paolo", "initials": "P", "orcid": "0000-0002-3066-4719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36e1a02e86a142c2b2d131154fb46f1c.json"}}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}], "type": "journal article", "published": "2020-11-12", "journal": {"title": "Cell", "issn": "1097-4172", "issn-l": "0092-8674", "volume": "183", "issue": "4", "pages": "968-981.e7"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is typically very mild and often asymptomatic in children. A complication is the rare multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, presenting 4-6 weeks after infection as high fever, organ dysfunction, and strongly elevated markers of inflammation. The pathogenesis is unclear but has overlapping features with Kawasaki disease suggestive of vasculitis and a likely autoimmune etiology. We apply systems-level analyses of blood immune cells, cytokines, and autoantibodies in healthy children, children with Kawasaki disease enrolled prior to COVID-19, children infected with SARS-CoV-2, and children presenting with MIS-C. We find that the inflammatory response in MIS-C differs from the cytokine storm of severe acute COVID-19, shares several features with Kawasaki disease, but also differs from this condition with respect to T cell subsets, interleukin (IL)-17A, and biomarkers associated with arterial damage. Finally, autoantibody profiling suggests multiple autoantibodies that could be involved in the pathogenesis of MIS-C.", "doi": "10.1016/j.cell.2020.09.016", "pmid": "32966765", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Research Area: Biomarkers and systems immunology": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pmc", "key": "PMC7474869"}, {"db": "pii", "key": "S0092-8674(20)31157-0"}], "notes": [], "created": "2020-10-28T09:09:22.496Z", "modified": "2023-06-19T15:18:37.668Z"}, {"entity": "publication", "iuid": "ff7aae8db2064115877b39738a00bea8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff7aae8db2064115877b39738a00bea8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff7aae8db2064115877b39738a00bea8"}}, "title": "Sleep and circadian problems during the coronavirus disease 2019 (COVID-19) pandemic: the International COVID-19 Sleep Study (ICOSS).", "authors": [{"family": "Partinen", "given": "Markku", "initials": "M"}, {"family": "Bjorvatn", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Chung", "given": "Frances", "initials": "F"}, {"family": "Penzel", "given": "Thomas", "initials": "T"}, {"family": "Espie", "given": "Colin A", "initials": "CA"}, {"family": "Morin", "given": "Charles M", "initials": "CM"}, {"family": "ICOSS-collaboration group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-12", "journal": {"title": "J Sleep Res", "issn": "1365-2869", "volume": null, "issue": null, "pages": "e13206", "issn-l": "0962-1105"}, "abstract": "This protocol paper describes the development of an international collaboration to survey several thousand adults from different countries around the world about their sleep during the coronavirus disease 2019 (COVID-19) pandemic. It is based on the development of a harmonised survey with 50 questions (106 different items) on sleep habits and sleep symptoms that permit comparability of information. The harmonised questionnaire may be used in anonymous cross-sectional surveys, and the instruments within the questionnaire may also be used in prospective studies and clinical studies. The aim was to develop a questionnaire to sample a variety of sleep-wake disorders and other symptoms likely to be caused by prolonged social confinement or by having had COVID-19. The questionnaire was designed to be: (a) simple and, (b) free to use, for research purposes, (c) multilingual, and (d) comprehensive. It can be completed in <30 min. By the end of June 2020, the survey questionnaire had been administered in Austria, Canada, China, Finland, France, Germany, Hong Kong, Italy, Japan, Norway, Poland, Sweden, UK and USA. Research questions to be addressed by the pooled data derived from the participating sites focus on describing the nature and rates of various sleep and circadian rhythms symptoms, as well as their psychological and medical correlates, that arise at various points during the COVID-19 pandemic.", "doi": "10.1111/jsr.13206", "pmid": "33179820", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-30T16:29:23.154Z", "modified": "2020-11-30T16:29:23.163Z"}, {"entity": "publication", "iuid": "c7c21924c4be4ba2893c3de7f6790186", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7c21924c4be4ba2893c3de7f6790186.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7c21924c4be4ba2893c3de7f6790186"}}, "title": "Local topology, bifurcations and mutation hot-spots in proteins with SARS-CoV-2 spike protein as an example", "authors": [{"family": "Peng", "given": "Xubiao", "initials": "X"}, {"family": "Niemi", "given": "Antti J", "initials": "AJ"}], "type": "posted-content", "published": "2020-11-12", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.11.11.378828", "pmid": null, "labels": {"Type: Preprint": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-03-08T15:03:36.462Z", "modified": "2021-04-15T19:03:01.894Z"}, {"entity": "publication", "iuid": "9c6ba4d480da4d18b2fcab1258dfd2e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9c6ba4d480da4d18b2fcab1258dfd2e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9c6ba4d480da4d18b2fcab1258dfd2e8"}}, "title": "Impact of COVID-19 pandemic on tuberculosis laboratory services in Europe.", "authors": [{"family": "Nikolayevskyy", "given": "Vlad", "initials": "V"}, {"family": "Holicka", "given": "Yen", "initials": "Y"}, {"family": "van Soolingen", "given": "Dick", "initials": "D"}, {"family": "van der Werf", "given": "Marieke J", "initials": "MJ"}, {"family": "K\u00f6dm\u00f6n", "given": "Csaba", "initials": "C"}, {"family": "Surkova", "given": "Elena", "initials": "E"}, {"family": "Hillemann", "given": "Doris", "initials": "D"}, {"family": "Groenheit", "given": "Ramona", "initials": "R"}, {"family": "Cirillo", "given": "Daniela", "initials": "D"}, {"family": "ERLTB-Net-2 study participants", "given": "", "initials": ""}], "type": "letter", "published": "2020-11-12", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "volume": null, "issue": null, "issn-l": "0903-1936"}, "abstract": null, "doi": "10.1183/13993003.03890-2020", "pmid": "33184119", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "13993003.03890-2020"}, {"db": "pmc", "key": "PMC7670866"}], "notes": [], "created": "2020-11-30T16:31:37.720Z", "modified": "2020-11-30T16:31:37.730Z"}, {"entity": "publication", "iuid": "10a1d6d31cd04809a438e3081949f053", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/10a1d6d31cd04809a438e3081949f053.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/10a1d6d31cd04809a438e3081949f053"}}, "title": "Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial.", "authors": [{"family": "Ponikowski", "given": "Piotr", "initials": "P"}, {"family": "Kirwan", "given": "Bridget-Anne", "initials": "BA"}, {"family": "Anker", "given": "Stefan D", "initials": "SD"}, {"family": "McDonagh", "given": "Theresa", "initials": "T"}, {"family": "Dorobantu", "given": "Maria", "initials": "M"}, {"family": "Drozdz", "given": "Jaros\u0142aw", "initials": "J"}, {"family": "Fabien", "given": "Vincent", "initials": "V"}, {"family": "Filippatos", "given": "Gerasimos", "initials": "G"}, {"family": "G\u00f6hring", "given": "Udo Michael", "initials": "UM"}, {"family": "Keren", "given": "Andre", "initials": "A"}, {"family": "Khintibidze", "given": "Irakli", "initials": "I"}, {"family": "Kragten", "given": "Hans", "initials": "H"}, {"family": "Martinez", "given": "Felipe A", "initials": "FA"}, {"family": "Metra", "given": "Marco", "initials": "M"}, {"family": "Milicic", "given": "Davor", "initials": "D"}, {"family": "Nicolau", "given": "Jos\u00e9 C", "initials": "JC"}, {"family": "Ohlsson", "given": "Marcus", "initials": "M"}, {"family": "Parkhomenko", "given": "Alexander", "initials": "A"}, {"family": "Pascual-Figal", "given": "Domingo A", "initials": "DA"}, {"family": "Ruschitzka", "given": "Frank", "initials": "F"}, {"family": "Sim", "given": "David", "initials": "D"}, {"family": "Skouri", "given": "Hadi", "initials": "H"}, {"family": "van der Meer", "given": "Peter", "initials": "P"}, {"family": "Lewis", "given": "Basil S", "initials": "BS"}, {"family": "Comin-Colet", "given": "Josep", "initials": "J"}, {"family": "von Haehling", "given": "Stephan", "initials": "S"}, {"family": "Cohen-Solal", "given": "Alain", "initials": "A"}, {"family": "Danchin", "given": "Nicolas", "initials": "N"}, {"family": "Doehner", "given": "Wolfram", "initials": "W"}, {"family": "Dargie", "given": "Henry J", "initials": "HJ"}, {"family": "Motro", "given": "Michael", "initials": "M"}, {"family": "Butler", "given": "Javed", "initials": "J"}, {"family": "Friede", "given": "Tim", "initials": "T"}, {"family": "Jensen", "given": "Klaus H", "initials": "KH"}, {"family": "Pocock", "given": "Stuart", "initials": "S"}, {"family": "Jankowska", "given": "Ewa A", "initials": "EA"}, {"family": "AFFIRM-AHF investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-12", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "396", "issue": "10266", "pages": "1895-1904", "issn-l": "0140-6736"}, "abstract": "Intravenous ferric carboxymaltose has been shown to improve symptoms and quality of life in patients with chronic heart failure and iron deficiency. We aimed to evaluate the effect of ferric carboxymaltose, compared with placebo, on outcomes in patients who were stabilised after an episode of acute heart failure.\n\nAFFIRM-AHF was a multicentre, double-blind, randomised trial done at 121 sites in Europe, South America, and Singapore. Eligible patients were aged 18 years or older, were hospitalised for acute heart failure with concomitant iron deficiency (defined as ferritin <100 \u03bcg/L, or 100-299 \u03bcg/L with transferrin saturation <20%), and had a left ventricular ejection fraction of less than 50%. Before hospital discharge, participants were randomly assigned (1:1) to receive intravenous ferric carboxymaltose or placebo for up to 24 weeks, dosed according to the extent of iron deficiency. To maintain masking of patients and study personnel, treatments were administered in black syringes by personnel not involved in any study assessments. The primary outcome was a composite of total hospitalisations for heart failure and cardiovascular death up to 52 weeks after randomisation, analysed in all patients who received at least one dose of study treatment and had at least one post-randomisation data point. Secondary outcomes were the composite of total cardiovascular hospitalisations and cardiovascular death; cardiovascular death; total heart failure hospitalisations; time to first heart failure hospitalisation or cardiovascular death; and days lost due to heart failure hospitalisations or cardiovascular death, all evaluated up to 52 weeks after randomisation. Safety was assessed in all patients for whom study treatment was started. A pre-COVID-19 sensitivity analysis on the primary and secondary outcomes was prespecified. This study is registered with ClinicalTrials.gov, NCT02937454, and has now been completed.\n\nBetween March 21, 2017, and July 30, 2019, 1525 patients were screened, of whom 1132 patients were randomly assigned to study groups. Study treatment was started in 1110 patients, and 1108 (558 in the carboxymaltose group and 550 in the placebo group) had at least one post-randomisation value. 293 primary events (57\u00b72 per 100 patient-years) occurred in the ferric carboxymaltose group and 372 (72\u00b75 per 100 patient-years) occurred in the placebo group (rate ratio [RR] 0\u00b779, 95% CI 0\u00b762-1\u00b701, p=0\u00b7059). 370 total cardiovascular hospitalisations and cardiovascular deaths occurred in the ferric carboxymaltose group and 451 occurred in the placebo group (RR 0\u00b780, 95% CI 0\u00b764-1\u00b700, p=0\u00b7050). There was no difference in cardiovascular death between the two groups (77 [14%] of 558 in the ferric carboxymaltose group vs 78 [14%] in the placebo group; hazard ratio [HR] 0\u00b796, 95% CI 0\u00b770-1\u00b732, p=0\u00b781). 217 total heart failure hospitalisations occurred in the ferric carboxymaltose group and 294 occurred in the placebo group (RR 0\u00b774; 95% CI 0\u00b758-0\u00b794, p=0\u00b7013). The composite of first heart failure hospitalisation or cardiovascular death occurred in 181 (32%) patients in the ferric carboxymaltose group and 209 (38%) in the placebo group (HR 0\u00b780, 95% CI 0\u00b766-0\u00b798, p=0\u00b7030). Fewer days were lost due to heart failure hospitalisations and cardiovascular death for patients assigned to ferric carboxymaltose compared with placebo (369 days per 100 patient-years vs 548 days per 100 patient-years; RR 0\u00b767, 95% CI 0\u00b747-0\u00b797, p=0\u00b7035). Serious adverse events occurred in 250 (45%) of 559 patients in the ferric carboxymaltose group and 282 (51%) of 551 patients in the placebo group.\n\nIn patients with iron deficiency, a left ventricular ejection fraction of less than 50%, and who were stabilised after an episode of acute heart failure, treatment with ferric carboxymaltose was safe and reduced the risk of heart failure hospitalisations, with no apparent effect on the risk of cardiovascular death.\n\nVifor Pharma.", "doi": "10.1016/S0140-6736(20)32339-4", "pmid": "33197395", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT02937454"}], "notes": [], "created": "2020-11-27T10:49:53.803Z", "modified": "2021-02-26T08:45:47.859Z"}, {"entity": "publication", "iuid": "8658ad0b159241be8e65c5b4f84da1dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8658ad0b159241be8e65c5b4f84da1dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8658ad0b159241be8e65c5b4f84da1dd"}}, "title": "Treating exuberant, non-resolving inflammation in the lung; Implications for acute respiratory distress syndrome and COVID-19.", "authors": [{"family": "Gilroy", "given": "Derek W", "initials": "DW"}, {"family": "De Maeyer", "given": "Roel P H", "initials": "RPH"}, {"family": "Tepper", "given": "Mark", "initials": "M"}, {"family": "O'Brien", "given": "Alastair", "initials": "A"}, {"family": "Uddin", "given": "Mohib", "initials": "M"}, {"family": "Chen", "given": "Judy", "initials": "J"}, {"family": "Goldstein", "given": "Daniel R", "initials": "DR"}, {"family": "Akbar", "given": "Arne N", "initials": "AN"}], "type": "journal article", "published": "2020-11-11", "journal": {"title": "Pharmacol Ther", "issn": "1879-016X", "volume": null, "issue": null, "pages": "107745", "issn-l": "0163-7258"}, "abstract": "While COVID-19, the disease driven by SARS-CoV-2 has ignited interest in the host immune response to this infection, it has also highlighted the lack of treatment options for the damaging inflammatory responses driven by pathogens that precipitate the acute respiratory distress syndrome (ARDS). With the global prevalence of SARS-CoV-2 and the likelihood of a second winter spike alongside seasonal flu, the need for effective and targeted anti-inflammatory agents is even more pressing. Here we discuss the aetiology of COVID-19 and the common signalling pathways driven by SARS-CoV-2, namely p38 MAP kinase. We highlight that p38 MAP kinase becomes elevated with increasing age, thereby driving many of the inflammatory pathways that precipitate death in old people with the added drawback of impairing vaccine efficacy in this susceptible age group. Finally, we review drugs available to inhibit p38 MAP kinase, their risks-versus-benefits as well as suggested dosing regimen to combat over-exuberant innate immune responses and potentially reverse vaccine inefficacy in older patients.", "doi": "10.1016/j.pharmthera.2020.107745", "pmid": "33188794", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0163-7258(20)30276-X"}, {"db": "pmc", "key": "PMC7657264"}], "notes": [], "created": "2020-11-27T11:01:14.577Z", "modified": "2020-11-27T11:03:48.877Z"}, {"entity": "publication", "iuid": "325ff1ba4f774ef5a692444fdd4878c1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/325ff1ba4f774ef5a692444fdd4878c1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/325ff1ba4f774ef5a692444fdd4878c1"}}, "title": "Long-distance airborne dispersal of SARS-CoV-2 in COVID-19 wards.", "authors": [{"family": "Nissen", "given": "Karolina", "initials": "K"}, {"family": "Krambrich", "given": "Janina", "initials": "J"}, {"family": "Akaberi", "given": "Dario", "initials": "D"}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Svensson", "given": "Lennart", "initials": "L"}, {"family": "Salaneck", "given": "Erik", "initials": "E"}], "type": "journal article", "published": "2020-11-11", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "10", "issue": "1", "pages": "19589"}, "abstract": "Evidence suggests that SARS-CoV-2, as well as other coronaviruses, can be dispersed and potentially transmitted by aerosols directly or via ventilation systems. We therefore investigated ventilation openings in one COVID-19 ward and central ducts that expel indoor air from three COVID-19 wards at Uppsala University Hospital, Sweden, during April and May 2020. Swab samples were taken from individual ceiling ventilation openings and surfaces in central ducts. Samples were subsequently subjected to rRT-PCR targeting the N and E genes of SARS-CoV-2. Central ventilation HEPA filters, located several stories above the wards, were removed and portions analyzed in the same manner. In two subsequent samplings, SARS-CoV-2 N and E genes were detected in seven and four out of 19 room vents, respectively. Central ventilation HEPA exhaust filters from the ward were found positive for both genes in three samples. Corresponding filters from two other, adjacent COVID-19 wards were also found positive. Infective ability of the samples was assessed by inoculation of susceptible cell cultures but could not be determined in these experiments. Detection of SARS-CoV-2 in central ventilation systems, distant from patient areas, indicate that virus can be transported long distances and that droplet transmission alone cannot reasonably explain this, especially considering the relatively low air change rates in these wards. Airborne transmission of SARS-CoV-2 must be taken into consideration for preventive measures.", "doi": "10.1038/s41598-020-76442-2", "pmid": "33177563", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-020-76442-2"}, {"db": "pmc", "key": "PMC7659316"}], "notes": [], "created": "2020-11-17T18:03:38.168Z", "modified": "2021-02-26T08:45:48.027Z"}, {"entity": "publication", "iuid": "028acc5d3ea24aa7b79c54b661dfed8d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/028acc5d3ea24aa7b79c54b661dfed8d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/028acc5d3ea24aa7b79c54b661dfed8d"}}, "title": "In silico and In vitro Studies Reveal Complement System Drives Coagulation Cascade in SARS-CoV-2 Pathogenesis.", "authors": [{"family": "Tiwari", "given": "Ritudhwaj", "initials": "R"}, {"family": "Mishra", "given": "Anurag R", "initials": "AR"}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "Gupta", "given": "Soham", "initials": "S"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}, {"family": "Nayak", "given": "Debasis", "initials": "D"}], "type": "journal article", "published": "2020-11-11", "journal": {"title": "Comput Struct Biotechnol J", "issn": "2001-0370", "volume": "18", "issue": null, "pages": "3734-3744", "issn-l": "2001-0370"}, "abstract": "The emergence and continued spread of SARS-CoV-2 have resulted in a public health emergency across the globe. The lack of knowledge on the precise mechanism of viral pathogenesis is impeding medical intervention. In this study, we have taken both in silico and in vitro experimental approaches to unravel the mechanism of viral pathogenesis associated with complement and coagulation pathways. Based on the structural similarities of viral and host proteins, we initially generated a protein-protein interactome profile. Further computational analysis combined with Gene Ontology (GO) analysis and KEGG pathway analysis predicted key annotated pathways associated with viral pathogenesis. These include MAPK signaling, complement, and coagulation cascades, endocytosis, PD-L1 expression, PD-1 checkpoint pathway in cancer and C-type lectin receptor signaling pathways. Degree centrality analysis pinned down to MAPK1, MAPK3, AKT1, and SRC are crucial drivers of signaling pathways and often overlap with the associated pathways. Most strikingly, the complement and coagulation cascade and platelet activation pathways are interconnected, presumably directing thrombotic activity observed in severe or critical cases of COVID-19. This is complemented by in vitro studies of Huh7 cell infection and analysis of the transcriptome and proteomic profile of gene candidates during viral infection. The most known candidates associated with complement and coagulation cascade signaling by KEGG pathway analysis showed significant up-regulated fold change during viral infection. Collectively both in silico and in vitro studies suggest complement and coagulation cascade signaling are a mechanism for intravascular coagulation, thrombotic changes, and associated complications in severe COVID-19 patients.", "doi": "10.1016/j.csbj.2020.11.005", "pmid": "33200027", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S2001-0370(20)30472-4"}, {"db": "pmc", "key": "PMC7657020"}], "notes": [], "created": "2020-11-19T19:43:58.111Z", "modified": "2021-04-23T15:18:24.542Z"}, {"entity": "publication", "iuid": "2042fa0ab0d14783b368a9ac51642f96", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2042fa0ab0d14783b368a9ac51642f96.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2042fa0ab0d14783b368a9ac51642f96"}}, "title": "How the Covid-19 pandemic is impacting sexual and reproductive health and rights and response: results from a global survey of providers, researchers, and policy makers.", "authors": [{"family": "Endler", "given": "Margit", "initials": "M"}, {"family": "Al-Haidari", "given": "Taghreed", "initials": "T"}, {"family": "Benedetto", "given": "Chiara", "initials": "C"}, {"family": "Chowdhury", "given": "Sameena", "initials": "S"}, {"family": "Christilaw", "given": "Jan", "initials": "J"}, {"family": "El Kak", "given": "Faysal", "initials": "F"}, {"family": "Galimberti", "given": "Diana", "initials": "D"}, {"family": "Garcia-Moreno", "given": "Claudia", "initials": "C"}, {"family": "Gutierrez", "given": "Miguel", "initials": "M"}, {"family": "Ibrahim", "given": "Shaimaa", "initials": "S"}, {"family": "Kumari", "given": "Shantha", "initials": "S"}, {"family": "McNicholas", "given": "Colleen", "initials": "C"}, {"family": "Mostajo Flores", "given": "Desir\u00e9e", "initials": "D"}, {"family": "Muganda", "given": "John", "initials": "J"}, {"family": "Ramirez-Negrin", "given": "Atziri", "initials": "A"}, {"family": "Senanayake", "given": "Hemantha", "initials": "H"}, {"family": "Sohail", "given": "Rubina", "initials": "R"}, {"family": "Temmerman", "given": "Marleen", "initials": "M"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}], "type": "journal article", "published": "2020-11-11", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": null, "issue": null, "issn-l": "0001-6349"}, "abstract": "We aimed to give a global overview of trends in access to sexual and reproductive health and rights (SRHR) during the Covid-19 pandemic and what is being done to mitigate its impact.\n\nWe performed a descriptive analysis and content analysis based on an online survey among clinicians, researchers and organizations. Our data was extracted from multiple-choice questions on access to SRHR services and risk of SRHR violations, and written responses to open-ended questions on threats to access and required response.\n\nThe survey was answered by 51 people representing 29 countries. 86% reported that access to contraceptive services was less or much less due to Covid-19, corresponding figures for surgical and medical abortion were 62% and 46%. The increased risk of gender-based and sexual violence was assessed as moderate or severe by 79%. Among countries with mildly restrictive abortion policies, 69% had implemented changes to facilitate access to abortion during the pandemic, compared to 0 among countries with severe restrictions (p<0.001), 87.5% compared to 46% had implemented changes to facilitate access to contraception (p= 0.023). The content analysis showed that i) prioritizations in health service delivery at the expense of SRHR, ii) lack of political will, iii) the detrimental effect of lock-down, and iv) the suspension of sexual education, were threats to SRHR access (theme 1). Requirements to mitigate these threats (theme 2) were i) political will and support of universal access to SRH services, ii) the sensitization of providers, vii) free public transport, and viii) physical protective equipment. A contrasting third theme was the state of exception of the Covid-19 pandemic as a window of opportunity to push forward women\u00b4s health and rights.\n\nMany countries have seen decreased access to and increased violations of SRHR during the Covid-19 pandemic. Countries with severe restrictions on abortion seem less likely to have implemented changes to SRHR delivery to mitigate this impact. Political will to support the advancement of SRHR is often lacking, which is fundamental to ensuring both continued access and, in a minority of cases, the solidification of gains made to SRHR during the pandemic.", "doi": "10.1111/aogs.14043", "pmid": "33179265", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-27T10:00:02.800Z", "modified": "2020-11-30T16:29:54.257Z"}, {"entity": "publication", "iuid": "dbfda0fdcd6d401ba68a4be038469ab5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dbfda0fdcd6d401ba68a4be038469ab5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dbfda0fdcd6d401ba68a4be038469ab5"}}, "title": "The issues of individualized medicine and pharmacovigilance: A consideration of COVID-19 and vaccination.", "authors": [{"family": "Ralph Edwards", "given": "I", "initials": "I"}, {"family": "Lindquist", "given": "Marie", "initials": "M"}], "type": "editorial", "published": "2020-11-10", "journal": {"title": "Int J Risk Saf Med", "issn": "1878-6847", "volume": "31", "issue": "4", "pages": "179-180", "issn-l": null}, "abstract": null, "doi": "10.3233/JRS-201008", "pmid": "33164947", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "JRS201008"}], "notes": [], "created": "2020-11-30T16:32:52.920Z", "modified": "2020-11-30T16:32:52.943Z"}, {"entity": "publication", "iuid": "af559716c7364d0bb301d8ef4144a058", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/af559716c7364d0bb301d8ef4144a058.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/af559716c7364d0bb301d8ef4144a058"}}, "title": "Surveillance of wastewater revealed peaks of SARS-CoV-2 preceding those of hospitalized patients with COVID-19.", "authors": [{"family": "Saguti", "given": "Fredy", "initials": "F"}, {"family": "Magnil", "given": "Ellen", "initials": "E"}, {"family": "Enache", "given": "Lucica", "initials": "L"}, {"family": "Churqui", "given": "Marianela Patzi", "initials": "MP"}, {"family": "Johansson", "given": "Anette", "initials": "A"}, {"family": "Lumley", "given": "Douglas", "initials": "D"}, {"family": "Davidsson", "given": "Fredrik", "initials": "F"}, {"family": "Dotevall", "given": "Leif", "initials": "L"}, {"family": "Mattsson", "given": "Ann", "initials": "A"}, {"family": "Trybala", "given": "Edward", "initials": "E"}, {"family": "Lagging", "given": "Martin", "initials": "M"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}, {"family": "Brezicka", "given": "Thomas", "initials": "T"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Norder", "given": "Hel\u00e9ne", "initials": "H"}], "type": "journal article", "published": "2020-11-10", "journal": {"title": "Water Res", "issn": "1879-2448", "issn-l": "0043-1354", "volume": "189", "issue": null, "pages": "116620"}, "abstract": "SARS-CoV-2 was discovered among humans in Wuhan, China in late 2019, and then spread rapidly, causing a global pandemic. The virus was found to be transmitted mainly by respiratory droplets from infected persons or by direct contact. It was also shown to be excreted in feces, why we investigated whether the virus could be detected in wastewater and if so, to which extent its levels reflects its spread in society. Samples of wastewater from the city of Gothenburg, and surrounding municipalities in Sweden were collected daily from mid-February until June 2020 at the Rya wastewater treatment plant. Flow proportional samples of wastewater were collected to ensure that comparable amounts were obtained for analysis. Daily samples were pooled into weekly samples. Virus was concentrated on a filter and analyzed by RT-qPCR. The amount of SARS-CoV-2 varied with peaks approximately every four week, preceding variations in number of newly hospitalized patients by 19-21 days. At that time virus testing for COVID-19 was limited to patients with severe symptoms. Local differences in viral spread was shown by analyzing weekly composite samples of wastewater from five sampling sites for four weeks. The highest amount of virus was found from the central, eastern, and northern parts of the city. SARS-CoV-2 was also found in the treated effluent wastewater from the WWTP discharged into the recipient, the G\u00f6ta River, although with a reduction of 4-log 10. The viral peaks with regular temporal intervals indicated that SARS-CoV-2 may have a cluster spread, probably reflecting that the majority of infected persons only spread the disease during a few days. Our results are important for both the planning of hospital care and to rapidly identify and intervene against local spread of the virus.", "doi": "10.1016/j.watres.2020.116620", "pmid": "33212338", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "NA", "key": "Provided in the article: amount of SARS-CoV-2 in wastewater in Gothenburg per week between February and June 2020", "description": null}], "notes": [], "created": "2020-11-24T07:37:09.624Z", "modified": "2021-02-26T08:46:13.439Z"}, {"entity": "publication", "iuid": "675c2e887707441982f23b3e80461e80", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/675c2e887707441982f23b3e80461e80.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/675c2e887707441982f23b3e80461e80"}}, "title": "Purchasing, consumption, demographic and socioeconomic variables associated with shifts in alcohol consumption during the COVID-19 pandemic.", "authors": [{"family": "Callinan", "given": "Sarah", "initials": "S"}, {"family": "Mojica-Perez", "given": "Yvette", "initials": "Y"}, {"family": "Wright", "given": "Cassandra J C", "initials": "CJC"}, {"family": "Livingston", "given": "Michael", "initials": "M"}, {"family": "Kuntsche", "given": "Sandra", "initials": "S"}, {"family": "Laslett", "given": "Anne-Marie", "initials": "A"}, {"family": "Room", "given": "Robin", "initials": "R"}, {"family": "Kuntsche", "given": "Emmanuel", "initials": "E"}], "type": "journal article", "published": "2020-11-10", "journal": {"title": "Drug Alcohol Rev", "issn": "1465-3362", "issn-l": "0959-5236", "volume": null, "issue": null, "pages": null}, "abstract": "Restrictions introduced to reduce the spread of COVID-19 have had major impacts on the living circumstances of Australians. This paper aims to provide insight into shifts in alcohol consumption and associated factors during the epidemic.\r\n\r\nA cross-sectional convenience sample of 2307 Australians aged 18 and over who drank at least monthly was recruited through social media. Respondents were asked about their alcohol consumption and purchasing in 2019 prior to the epidemic plus similar questions about their experiences in the month prior to being surveyed between 29 April and 16 May 2020.\r\n\r\nReports of average consumption before (3.53 drinks per day [3.36, 3.71 95% confidence interval]) and during (3.52 [3.34, 3.69]) the pandemic were stable. However, young men and those who drank more outside the home in 2019 reported decreased consumption during the pandemic, and people with high levels of stress and those who bulk-bought alcohol when restrictions were announced reported an increase in consumption relative to those who did not.\r\n\r\nA reported increase in consumption among those experiencing more stress suggests that some people may have been drinking to cope during the epidemic. Conversely, the reported decrease in consumption among those who drank more outside of their home in 2019 suggests that closing all on-trade sales did not result in complete substitution of on-premise drinking with home drinking in this group. Monitoring of relevant subgroups to assess long-term changes in consumption in the aftermath of the epidemic is recommended.", "doi": "10.1111/dar.13200", "pmid": "33170976", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2020-11-27T10:01:48.823Z", "modified": "2021-02-26T08:47:00.003Z"}, {"entity": "publication", "iuid": "a47dbc0890e6411dbb49a80752e594ad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a47dbc0890e6411dbb49a80752e594ad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a47dbc0890e6411dbb49a80752e594ad"}}, "title": "EAES Recommendations for Recovery Plan in Minimally Invasive Surgery Amid COVID-19 Pandemic.", "authors": [{"family": "Arezzo", "given": "Alberto", "initials": "A"}, {"family": "Francis", "given": "Nader", "initials": "N"}, {"family": "Mintz", "given": "Yoav", "initials": "Y"}, {"family": "Adamina", "given": "Michel", "initials": "M"}, {"family": "Antoniou", "given": "Stavros A", "initials": "SA"}, {"family": "Bouvy", "given": "Nicole", "initials": "N"}, {"family": "Copaescu", "given": "Catalin", "initials": "C"}, {"family": "de Manzini", "given": "Nicol\u00f2", "initials": "N"}, {"family": "Di Lorenzo", "given": "Nicola", "initials": "N"}, {"family": "Morales-Conde", "given": "Salvador", "initials": "S"}, {"family": "M\u00fcller-Stich", "given": "Beat P", "initials": "BP"}, {"family": "Nickel", "given": "Felix", "initials": "F"}, {"family": "Popa", "given": "Dorin", "initials": "D"}, {"family": "Tait", "given": "Diana", "initials": "D"}, {"family": "Thomas", "given": "Cenydd", "initials": "C"}, {"family": "Nimmo", "given": "Susan", "initials": "S"}, {"family": "Paraskevis", "given": "Dimitrios", "initials": "D"}, {"family": "Pietrabissa", "given": "Andrea", "initials": "A"}, {"family": "EAES Group of Experts for Recovery Amid COVID-19 Pandemic", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-10", "journal": {"title": "Surg Endosc", "issn": "1432-2218", "volume": null, "issue": null, "issn-l": null}, "abstract": "COVID-19 pandemic presented an unexpected challenge for the surgical community in general and Minimally Invasive Surgery (MIS) specialists in particular. This document aims to summarize recent evidence and experts' opinion and formulate recommendations to guide the surgical community on how to best organize the recovery plan for surgical activity across different sub-specialities after the COVID-19 pandemic.\n\nRecommendations were developed through a Delphi process for establishment of expert consensus. Domain topics were formulated and subsequently subdivided into questions pertinent to different surgical specialities following the COVID-19 crisis. Sixty-five experts from 24 countries, representing the entire EAES board, were invited. Fifty clinicians and six engineers accepted the invitation and drafted statements based on specific key questions. Anonymous voting on the statements was performed until consensus was achieved, defined by at least 70% agreement.\n\nA total of 92 consensus statements were formulated with regard to safe resumption of surgery across eight domains, addressing general surgery, upper GI, lower GI, bariatrics, endocrine, HPB, abdominal wall and technology/research. The statements addressed elective and emergency services across all subspecialties with specific attention to the role of MIS during the recovery plan. Eighty-four of the statements were approved during the first round of Delphi voting (91.3%) and another 8 during the following round after substantial modification, resulting in a 100% consensus.\n\nThe recommendations formulated by the EAES board establish a framework for resumption of surgery following COVID-19 pandemic with particular focus on the role of MIS across surgical specialities. The statements have the potential for wide application in the clinical setting, education activities and research work across different healthcare systems.", "doi": "10.1007/s00464-020-08131-0", "pmid": "33170335", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00464-020-08131-0"}, {"db": "pmc", "key": "PMC7653984"}], "notes": [], "created": "2020-11-30T16:30:45.726Z", "modified": "2020-11-30T16:30:45.750Z"}, {"entity": "publication", "iuid": "bb567e9f4e7a4b8c9a0463a6c345d634", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb567e9f4e7a4b8c9a0463a6c345d634.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb567e9f4e7a4b8c9a0463a6c345d634"}}, "title": "Prone positioning in mechanically ventilated patients with severe acute respiratory distress syndrome and coronavirus disease 2019.", "authors": [{"family": "Gleissman", "given": "Helena", "initials": "H"}, {"family": "Forsgren", "given": "Anders", "initials": "A"}, {"family": "Andersson", "given": "Elisabeth", "initials": "E"}, {"family": "Lindqvist", "given": "Elin", "initials": "E"}, {"family": "Lipka Falck", "given": "Adam", "initials": "A"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Dahlberg", "given": "Martin", "initials": "M"}, {"family": "G\u00fcnther", "given": "Mattias", "initials": "M"}], "type": "journal article", "published": "2020-11-09", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "volume": null, "issue": null, "issn-l": "0001-5172"}, "abstract": "The management of COVID-19 ARDS is debated. Although current evidence does not suggest an atypical acute respiratory distress syndrome (ARDS), the physiological response to prone positioning is not fully understood and it is unclear which patients benefit. We aimed to determine whether proning increases oxygenation and to evaluate responders.\n\nThis case series from a single, tertiary university hospital includes all mechanically ventilated patients with COVID-19 and proning between 17 March 2020 and 19 May 2020. The primary measure was change in PaO 2 :FiO2 .\n\nForty-four patients, 32 males/12 females, were treated with proning for a total of 138 sessions, with median (range) two (1-8) sessions. Median (IQR) time for the five sessions was 14 (12-17) hours. In the first session, median (IQR) PaO 2 :FiO2 increased from 104 (86-122) to 161 (127-207) mm Hg (P < .001). 36/44 patients (82%) improved in PaO2 :FiO2 , with a significant increase in PaO2 :FiO2 in the first three sessions. Median (IQR) FiO2 decreased from 0.7 (0.6-0.8) to 0.5 (0.35-0.6) (<0.001). A significant decrease occurred in the first three sessions. PaO2 , tidal volumes, PEEP, mean arterial pressure (MAP), and norepinephrine infusion did not differ. Primarily, patients with PaO2 :FiO2 approximately < 120 mm Hg before treatment responded to proning. Age, sex, BMI, or SAPS 3 did not predict success in increasing PaO2 :FiO2 .\n\nProning increased PaO 2 :FiO2 , primarily in patients with PaO2 :FiO2 approximately < 120 mm Hg, with a consistency over three sessions. No characteristic was associated with non-responding, why proning may be considered in most patients. Further study is required to evaluate mortality.", "doi": "10.1111/aas.13741", "pmid": "33165936", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-27T10:05:33.757Z", "modified": "2021-02-26T08:45:48.620Z"}, {"entity": "publication", "iuid": "fe33af25ffb64d688a4a3fb24a350de4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fe33af25ffb64d688a4a3fb24a350de4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fe33af25ffb64d688a4a3fb24a350de4"}}, "title": "COVID-19 during Pregnancy and Postpartum.", "authors": [{"family": "Naidu Ms PharmD", "given": "Sreus A G", "initials": "SAG"}, {"family": "Clemens DrPH Fift Cfs Fasn Facn Cns Fiafst", "given": "Roger A", "initials": "RA"}, {"family": "Pressman Md Ms Facn", "given": "Peter", "initials": "P"}, {"family": "Zaigham BSc Md PhD", "given": "Mehreen", "initials": "M"}, {"family": "Kadkhoda PhD Sm Ascp D Abmm D Abmli", "given": "Kamran", "initials": "K"}, {"family": "Davies PhD DSc Mae Frsc Frcp Fls Fri", "given": "Kelvin J A", "initials": "KJA"}, {"family": "Naidu PhD Facn Fls Fissvd", "given": "A Satyanarayan", "initials": "AS"}], "type": "journal article", "published": "2020-11-08", "journal": {"title": "J Diet Suppl", "issn": "1939-022X", "volume": null, "issue": null, "pages": "1-28", "issn-l": "1939-0211"}, "abstract": "Coronavirus Disease 2019 (COVID-19) triggered by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection has been declared a pandemic by the World Health Organization (WHO) on March 11, 2020. Oxidative stress and its related metabolic syndromes are potential risk factors in the susceptibility to, and severity of COVID-19. In concert with the earliest reports of COVID-19, obstetricians started to diagnose and treat SARS-CoV-2 infections during pregnancy (\"COVID-19-Pregnancy\"). High metabolic demand to sustain normal fetal development increases the burden of oxidative stress in pregnancy. Intracellular redox changes intertwined with acute phase responses at the maternal-fetal interface could amplify during pregnancy. Interestingly, mother-to-fetus transmission of SARS-CoV-2 has not been detected in most of the COVID-19-Pregnancy cases. This relative absence of vertical transmission may be related to the presence of lactoferrin in the placenta, amniotic fluid, and lacteal secretions. However, the cytokine-storm induced during COVID-19-Pregnancy may cause severe inflammatory damage to the fetus, and if uncontrolled, may later result in autism spectrum-like disorders and brain development abnormalities in neonates. Considering this serious health threat to child growth and development, the prevention of COVID-19 during pregnancy should be considered a high priority. This review summarizes the intricate virulence factors of COVID-19 and elucidate its pathobiological spectrum during pregnancy and postpartum periods with a focus on the putative and complex roles of endogenous and exogenous lactoferrin in conferring immunological advantage to the host.", "doi": "10.1080/19390211.2020.1834049", "pmid": "33164601", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-27T11:01:15.701Z", "modified": "2020-11-27T11:03:50.332Z"}, {"entity": "publication", "iuid": "e6ab3a8d7c344df9bb18ae2700312888", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6ab3a8d7c344df9bb18ae2700312888.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6ab3a8d7c344df9bb18ae2700312888"}}, "title": "How children and young people can stay physically active during the novel coronavirus pandemic while take into account safety measures and precautions.", "authors": [{"family": "Fr\u00f6berg", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2020-11-07", "journal": {"title": "Health Promot Perspect", "issn": "2228-6497", "volume": "10", "issue": "4", "pages": "295-299", "issn-l": null}, "abstract": "The novel coronavirus (COVID-19) outbreak has caused major public concern and posed challenges to societies across the globe. The COVID-19 pandemic might have implications for health-related behaviors, such as physical activity, among people in different age groups. Lately, a number of papers have offered suggestions and recommendations on how to stay physically active during the novel coronavirus pandemic while take into account safety measures and precautions. Many of these suggestions and recommendations might be relevant for health professionals and health practitioners working to facilitate physical activity, health, and well-being among children and young people. In light of the COVID-19pandemic, this paper provides an overview of (a) suggestions and recommendations on physical activities; and (b) safety measures and precautions while being physically active.", "doi": "10.34172/hpp.2020.47", "pmid": "33312924", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7722993"}], "notes": [], "created": "2020-12-21T10:18:32.884Z", "modified": "2021-02-26T08:47:00.269Z"}, {"entity": "publication", "iuid": "511d36d8ecdb449d868b55a96b910565", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/511d36d8ecdb449d868b55a96b910565.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/511d36d8ecdb449d868b55a96b910565"}}, "title": "Weak anti-SARS-CoV-2 antibody response is associated with mortality in a Swedish cohort of COVID-19 patients in critical care.", "authors": [{"family": "Asif", "given": "Sana", "initials": "S"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Kristensen", "given": "Bjarne", "initials": "B"}, {"family": "Alving", "given": "Kjell", "initials": "K"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7144f918db54be0b41b5645d02c85a7.json"}}], "type": "journal article", "published": "2020-11-06", "journal": {"title": "Crit Care", "issn": "1466-609X", "issn-l": "1364-8535", "volume": "24", "issue": "1", "pages": "639"}, "abstract": null, "doi": "10.1186/s13054-020-03362-y", "pmid": "33158455", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-020-03362-y"}, {"db": "pmc", "key": "PMC7645408"}], "notes": [], "created": "2020-11-11T07:29:15.329Z", "modified": "2022-02-14T07:49:35.193Z"}, {"entity": "publication", "iuid": "42eac4db2cb44eb59410e1021db054ad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/42eac4db2cb44eb59410e1021db054ad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/42eac4db2cb44eb59410e1021db054ad"}}, "title": "Utility of Proteomics in Emerging and Re-Emerging Infectious Diseases Caused by RNA Viruses.", "authors": [{"family": "Sperk", "given": "Maike", "initials": "M"}, {"family": "van Domselaar", "given": "Robert", "initials": "R"}, {"family": "Rodriguez", "given": "Jimmy Esneider", "initials": "JE"}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "S\u00e1 Vinhas", "given": "Beatriz", "initials": "B"}, {"family": "Saccon", "given": "Elisa", "initials": "E"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Singh", "given": "Kamal", "initials": "K"}, {"family": "Gupta", "given": "Soham", "initials": "S"}, {"family": "V\u00e9gv\u00e1ri", "given": "\u00c1kos", "initials": "\u00c1"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "journal article", "published": "2020-11-06", "journal": {"title": "J Proteome Res", "issn": "1535-3907", "issn-l": null, "volume": "19", "issue": "11", "pages": "4259-4274"}, "abstract": "Emerging and re-emerging infectious diseases due to RNA viruses cause major negative consequences for the quality of life, public health, and overall economic development. Most of the RNA viruses causing illnesses in humans are of zoonotic origin. Zoonotic viruses can directly be transferred from animals to humans through adaptation, followed by human-to-human transmission, such as in human immunodeficiency virus (HIV), severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and, more recently, SARS coronavirus 2 (SARS-CoV-2), or they can be transferred through insects or vectors, as in the case of Crimean-Congo hemorrhagic fever virus (CCHFV), Zika virus (ZIKV), and dengue virus (DENV). At the present, there are no vaccines or antiviral compounds against most of these viruses. Because proteins possess a vast array of functions in all known biological systems, proteomics-based strategies can provide important insights into the investigation of disease pathogenesis and the identification of promising antiviral drug targets during an epidemic or pandemic. Mass spectrometry technology has provided the capacity required for the precise identification and the sensitive and high-throughput analysis of proteins on a large scale and has contributed greatly to unravelling key protein-protein interactions, discovering signaling networks, and understanding disease mechanisms. In this Review, we present an account of quantitative proteomics and its application in some prominent recent examples of emerging and re-emerging RNA virus diseases like HIV-1, CCHFV, ZIKV, and DENV, with more detail with respect to coronaviruses (MERS-CoV and SARS-CoV) as well as the recent SARS-CoV-2 pandemic.", "doi": "10.1021/acs.jproteome.0c00380", "pmid": "33095583", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7640957"}], "notes": [], "created": "2020-12-01T15:33:37.364Z", "modified": "2021-02-26T08:45:02.967Z"}, {"entity": "publication", "iuid": "7bb177f83a4e475e9037154ad9bdc8f1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7bb177f83a4e475e9037154ad9bdc8f1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7bb177f83a4e475e9037154ad9bdc8f1"}}, "title": "The Impact of COVID-19 on Criminal Investigations and Proceedings in Sweden - A Snapshot of Practitioners' Realities.", "authors": [{"family": "Lid\u00e9n", "given": "Moa", "initials": "M"}], "type": "journal article", "published": "2020-11-06", "journal": {"title": "Forensic Sci Int", "issn": "2589-871X", "issn-l": null, "volume": "2", "issue": null, "pages": "325-332"}, "abstract": "Since well-functioning criminal investigations and proceedings are crucial parts of a society governed by the rule of law, it is essential to understand whether and how they are impacted by the current COVID-19 pandemic. The Swedish context provides an interesting case study and comparison to developments in other countries which have introduced more far-reaching interventions such as lockdowns. In this study, Swedish practitioners (N =10), including police officers, forensic pathologists, prosecutors, defense counsels and judges, participated in an online survey in which they gave their views on the pandemic's impact on their work situations. The overall results show that the major impact was on their work methods, with transitions to using more online methods and increased remote working, while the smallest impact was noted in relation to work character, including crime and evidence types which have remained relatively constant. Forensic pathologists reported the largest impact on work quality, although there was large individual variation in their responses. On a general level, the practitioners perceived that the measures undertaken at their work places were relatively sufficient and also perceived of the risk of contracting or spreading the virus as relatively low but also this was associated with large individual variation. Given the small sample of practitioners and that practitioners' responses relate to an early stage of what is presumed to be a prolonged pandemic, replication as well as caution in interpreting the results are needed.", "doi": "10.1016/j.fsisyn.2020.11.001", "pmid": "33294832", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S2589-871X(20)30065-6"}, {"db": "pmc", "key": "PMC7689508"}], "notes": [], "created": "2020-12-13T07:20:58.444Z", "modified": "2022-11-09T08:25:07.841Z"}, {"entity": "publication", "iuid": "c493f63a0cbc43c396383a4cf1232f85", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c493f63a0cbc43c396383a4cf1232f85.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c493f63a0cbc43c396383a4cf1232f85"}}, "title": "Is It Just About Physical Health? An Online Cross-Sectional Study Exploring the Psychological Distress Among University Students in Jordan in the Midst of COVID-19 Pandemic.", "authors": [{"family": "Al-Tammemi", "given": "Ala'a B", "initials": "AB"}, {"family": "Akour", "given": "Amal", "initials": "A"}, {"family": "Alfalah", "given": "Laith", "initials": "L"}], "type": "journal article", "published": "2020-11-06", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "11", "issue": null, "pages": "562213"}, "abstract": "Since the spread of COVID-19 on a global scale, most of efforts at national and international levels were directed to mitigate the spread of the disease and its physical harm, paying less attention to the psychological impacts of COVID-19 on global mental health especially at early stages of the pandemic.\r\n\r\nThis study aimed to assess and explore (i) The levels of psychological distress and its correlates (ii) Motivation for distance learning (iii) Coping activities and pandemic related concerns, among university students in Jordan in the midst of COVID-19 pandemic.\r\n\r\nA cross-sectional study was conducted using an online self-administered questionnaire. The measure of psychological distress was obtained using the 10-item Kessler Psychological Distress Scale, while other questions have explored our study's second and third aims.\r\n\r\nA total of 381 completed questionnaires were included in the analysis. Female participants slightly predominated the sample ( n = 199, 52.2%). The respondents aged 18-38 years (mean 22.6 years, SD: 3.16). Concerning distress severity, most of respondents were regarded as having severe psychological distress (n = 265, 69.5%). 209 students (54.9%) reported that they had no motivation for distance learning. Ordinal logistic regression revealed a significant correlation between distress severity and many predictors. Among the predictors that were found to act as protective factors against higher levels of distress included older age (aOR = 0.64, P = 0.022; 95% CI: 0.44-0.94), and having a strong motivation for distance learning (aOR = 0.10, P = 0.048; 95% CI: 0.01-0.96). In contrary, being a current smoker (aOR = 1.99, P = 0.049; 95% CI: 1.10-3.39), and having no motivation for distance learning (aOR = 2.49, P = 0.007; 95% CI: 1.29-4.80) acted as risk factors for having higher levels of psychological distress among the students. The most common coping activity reported was spending more time on social media platforms (n = 269, 70.6%), and 209 students (54.9%) reported distance learning as their most distressing concern.\r\n\r\nThe COVID-19 pandemic and related control measures could impact the mental health of individuals, including students. We recommend a nationwide psychological support program to be incorporated into Jordan's preparedness plan and response strategy in combating the COVID-19 pandemic.", "doi": "10.3389/fpsyg.2020.562213", "pmid": "33240151", "labels": {"Type: Journal article": null, "Category: Public Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-11-27T10:26:56.700Z", "modified": "2022-11-09T08:26:17.199Z"}, {"entity": "publication", "iuid": "f7f7b25eb9d046b4baf27e0470dc9510", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7f7b25eb9d046b4baf27e0470dc9510.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7f7b25eb9d046b4baf27e0470dc9510"}}, "title": "COVID-19: Nanomedicine Uncovers Blood-Clot Mystery.", "authors": [{"family": "Saei", "given": "Amir Ata", "initials": "AA"}, {"family": "Sharifi", "given": "Shahriar", "initials": "S"}, {"family": "Mahmoudi", "given": "Morteza", "initials": "M"}], "type": "journal article", "published": "2020-11-06", "journal": {"title": "J Proteome Res", "issn": "1535-3907", "volume": "19", "issue": "11", "pages": "4364-4373", "issn-l": null}, "abstract": "Further complications associated with infection by severe acute respiratory syndrome coronavirus 2 (a.k.a. SARS-CoV-2) continue to be reported. Very recent findings reveal that 20-30% of patients at high risk of mortality from COVID-19 infection experience blood clotting that leads to stroke and sudden death. Timely assessment of the severity of blood clotting will be of enormous help to clinicians in determining the right blood-thinning medications to prevent stroke or other life-threatening consequences. Therefore, rapid identification of blood-clotting-related proteins in the plasma of COVID-19 patients would save many lives. Several nanotechnology-based approaches are being developed to diagnose patients at high risk of death due to complications from COVID-19 infections, including blood clots. This Perspective outlines (i) the significant potential of nanomedicine in assessing the risk of blood clotting and its severity in SARS-CoV-2 infected patients and (ii) its synergistic roles with advanced mass-spectrometry-based proteomics approaches in identifying the important protein patterns that are involved in the occurrence and progression of this disease. The combination of such powerful tools might help us understand the clotting phenomenon and pave the way for development of new diagnostics and therapeutics in the fight against COVID-19.", "doi": "10.1021/acs.jproteome.0c00425", "pmid": "32790309", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7640964"}], "notes": [], "created": "2020-12-07T13:26:03.336Z", "modified": "2020-12-07T13:26:03.347Z"}, {"entity": "publication", "iuid": "facb78b4ec404e50a6986cb53cf8a3ec", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/facb78b4ec404e50a6986cb53cf8a3ec.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/facb78b4ec404e50a6986cb53cf8a3ec"}}, "title": "Searching for target-specific and multi-targeting organics for Covid-19 in the Drugbank database with a double scoring approach.", "authors": [{"family": "Murugan", "given": "Natarajan Arul", "initials": "NA"}, {"family": "Kumar", "given": "Sanjiv", "initials": "S"}, {"family": "Jeyakanthan", "given": "Jeyaraman", "initials": "J"}, {"family": "Srivastava", "given": "Vaibhav", "initials": "V"}], "type": "journal article", "published": "2020-11-05", "journal": {"title": "Sci Rep", "issn": "2045-2322", "issn-l": "2045-2322", "volume": "10", "issue": "1", "pages": "19125"}, "abstract": "The current outbreak of Covid-19 infection due to SARS-CoV-2, a virus from the coronavirus family, has become a major threat to human healthcare. The virus has already infected more than 44 M people and the number of deaths reported has reached more than 1.1 M which may be attributed to lack of medicine. The traditional drug discovery approach involves many years of rigorous research and development and demands for a huge investment which cannot be adopted for the ongoing pandemic infection. Rather we need a swift and cost-effective approach to inhibit and control the viral infection. With the help of computational screening approaches and by choosing appropriate chemical space, it is possible to identify lead drug-like compounds for Covid-19. In this study, we have used the Drugbank database to screen compounds against the most important viral targets namely 3C-like protease (3CLpro), papain-like protease (PLpro), RNA-dependent RNA polymerase (RdRp) and the spike (S) protein. These targets play a major role in the replication/transcription and host cell recognition, therefore, are vital for the viral reproduction and spread of infection. As the structure based computational screening approaches are more reliable, we used the crystal structures for 3C-like main protease and spike protein. For the remaining targets, we used the structures based on homology modeling. Further, we employed two scoring methods based on binding free energies implemented in AutoDock Vina and molecular mechanics-generalized Born surface area approach. Based on these results, we propose drug cocktails active against the three viral targets namely 3CLpro, PLpro and RdRp. Interestingly, one of the identified compounds in this study i.e. Baloxavir marboxil has been under clinical trial for the treatment of Covid-19 infection. In addition, we have identified a few compounds such as Phthalocyanine, Tadalafil, Lonafarnib, Nilotinib, Dihydroergotamine, R-428 which can bind to all three targets simultaneously and can serve as multi-targeting drugs. Our study also included calculation of binding energies for various compounds currently under drug trials. Among these compounds, it is found that Remdesivir binds to targets, 3CLpro and RdRp with high binding affinity. Moreover, Baricitinib and Umifenovir were found to have superior target-specific binding while Darunavir is found to be a potential multi-targeting drug. As far as we know this is the first study where the compounds from the Drugbank database are screened against four vital targets of SARS-CoV-2 and illustrates that the computational screening using a double scoring approach can yield potential drug-like compounds against Covid-19 infection.", "doi": "10.1038/s41598-020-75762-7", "pmid": "33154404", "labels": {"Type: Journal article": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-020-75762-7"}, {"db": "pmc", "key": "PMC7645721"}], "notes": [], "created": "2020-12-01T14:46:02.174Z", "modified": "2021-02-26T08:45:25.943Z"}, {"entity": "publication", "iuid": "751306da9bde4244b9913b6fd059cf8d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/751306da9bde4244b9913b6fd059cf8d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/751306da9bde4244b9913b6fd059cf8d"}}, "title": "Hospital preparedness challenges in biological disasters: A qualitative study.", "authors": [{"family": "Aminizadeh", "given": "Mohsen", "initials": "M"}, {"family": "Farrokhi", "given": "Mehrdad", "initials": "M"}, {"family": "Ebadi", "given": "Abbas", "initials": "A"}, {"family": "Masoumi", "given": "Gholam Reza", "initials": "GR"}, {"family": "Kolivand", "given": "Pirhossein", "initials": "P"}, {"family": "Khankeh", "given": "Hamid Reza", "initials": "HR"}], "type": "journal article", "published": "2020-11-05", "journal": {"title": "Disaster Med Public Health Prep", "issn": "1938-744X", "issn-l": "1935-7893", "volume": null, "issue": null, "pages": "1-13"}, "abstract": "Identification of hospital preparedness challenges against biological events such as COVID-19 is essential to improve dynamics, quality and business continuity confidence in the health system. Accordingly, the purpose of the present study is to evaluate the challenges of hospital preparedness in biological events.\r\n\r\nThis study employed a qualitative method using content analysis in which 20 healthcare managers and experts who are experienced in biological events were selected through purposeful sampling. The data collection was done through semi-structured interviews, which continued until data saturation. The data were analyzed using qualitative content analysis as well as the Landman and Graneheim Approach.\r\n\r\nSix main concepts (training and practice, resource management, safety and health, patient management, risk communication, and laboratory and surveillance) and 14 sub-concepts were extracted on hospital preparedness challenges in biological events through analyzing interviews.\r\n\r\nThe present study indicated that the health system of the country faces many challenges in response to biological events and threats. Moreover, study participants indicated that Iranian hospitals were not prepared for biological events. It is recommended to design preparedness plans of hospitals based on preparedness standards for biological events. In addition, comprehensive measures are required to enhance their capacity to respond to biological emergencies.", "doi": "10.1017/dmp.2020.434", "pmid": "33148363", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S1935789320004346"}], "notes": [], "created": "2020-11-27T10:13:26.533Z", "modified": "2022-11-09T08:27:25.836Z"}, {"entity": "publication", "iuid": "d5b3f3d7bcd049fea392cd3db33852a2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5b3f3d7bcd049fea392cd3db33852a2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5b3f3d7bcd049fea392cd3db33852a2"}}, "title": "Effect and safety of Chinese herbal medicine granules in patients with severe coronavirus disease 2019 in Wuhan, China: a retrospective, single-center study with propensity score matching.", "authors": [{"family": "Wang", "given": "Yuanyuan", "initials": "Y"}, {"family": "Liu", "given": "Yuntao", "initials": "Y"}, {"family": "Lv", "given": "Qingquan", "initials": "Q"}, {"family": "Zheng", "given": "Danwen", "initials": "D"}, {"family": "Zhou", "given": "Li", "initials": "L"}, {"family": "Ouyang", "given": "Wenwei", "initials": "W"}, {"family": "Ding", "given": "Banghan", "initials": "B"}, {"family": "Zou", "given": "Xu", "initials": "X"}, {"family": "Yan", "given": "Fang", "initials": "F"}, {"family": "Liu", "given": "Bo", "initials": "B"}, {"family": "Chen", "given": "Jun", "initials": "J"}, {"family": "Liu", "given": "Tianzhu", "initials": "T"}, {"family": "Fu", "given": "Chicheng", "initials": "C"}, {"family": "Fang", "given": "Qu", "initials": "Q"}, {"family": "Wang", "given": "Yi", "initials": "Y"}, {"family": "Li", "given": "Fang", "initials": "F"}, {"family": "Chen", "given": "Ailan", "initials": "A"}, {"family": "Lundborg", "given": "Cecilia St\u00e5lsby", "initials": "CS"}, {"family": "Guo", "given": "Jianwen", "initials": "J"}, {"family": "Wen", "given": "Zehuai", "initials": "Z"}, {"family": "Zhang", "given": "Zhongde", "initials": "Z"}], "type": "journal article", "published": "2020-11-05", "journal": {"title": "Phytomedicine", "issn": "1618-095X", "volume": null, "issue": null, "pages": "153404", "issn-l": "0944-7113"}, "abstract": "Chinese herbal medicine (CHM) has been used for severe illness caused by coronavirus disease 2019 (COVID-19), but its treatment effects and safety are unclear.\n\nThis study reviews the effect and safety of CHM granules in the treatment of patients with severe COVID-19.\n\nWe conducteda single-center, retrospective study on patients with severe COVID-19 in a designated hospital in Wuhan from January 15, 2020 to March 30, 2020. The propensity score matching (PSM) was used to assess the effect and safety of the treatment using CHM granules. The ratio of patients who received treatment with CHM granules combined with usual care and those who received usual care alone was 1:1. The primary outcome was the time to clinical improvement within 28 days, defined as the time taken for the patients' health to show improvement by decline of two categories (from the baseline) on a modified six-category ordinal scale, or to be dischargedfrom the hospital before Day 28.\n\nUsing PSM, 43 patients (45% male) aged 65.6 (57-70) yearsfrom each group were exactly matched. No significant difference was observed in clinical improvement of patients treated with CHM granules compared with those who received usual (p = 0.851). However, the use of CHM granules reduced the 28-day mortality (p = 0.049) and shortened the duration of fever (4 days vs. 7 days, p = 0.002). The differences in the duration of cough and dyspnea and the difference in lung lesion ratio on computerized tomography scans were not significant.Commonly,patients in the CHM group had an increased D-dimer level (p = 0.036).\n\nForpatients with severe COVID-19, CHM granules, combined with usual care, showed no improvement beyond usual care alone. However, the use of CHM granules reduced the 28-day mortality rate and the time to fever alleviation. Nevertheless, CHM granules may be associated with high risk of fibrinolysis.", "doi": "10.1016/j.phymed.2020.153404", "pmid": "33637412", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0944-7113(20)30235-X"}], "notes": [], "created": "2021-03-01T10:28:51.462Z", "modified": "2021-03-01T10:28:51.473Z"}, {"entity": "publication", "iuid": "cd7cc72539de42339a8adea9f3ffbed2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd7cc72539de42339a8adea9f3ffbed2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd7cc72539de42339a8adea9f3ffbed2"}}, "title": "Differences of SARS-CoV-2 serological test performance between hospitalized and outpatient COVID-19 cases.", "authors": [{"family": "Wolf", "given": "Johannes", "initials": "J"}, {"family": "Kaiser", "given": "Thorsten", "initials": "T"}, {"family": "Pehnke", "given": "Sarah", "initials": "S"}, {"family": "Nickel", "given": "Olaf", "initials": "O"}, {"family": "L\u00fcbbert", "given": "Christoph", "initials": "C"}, {"family": "Kalbitz", "given": "Sven", "initials": "S"}, {"family": "Arnold", "given": "Benjamin", "initials": "B"}, {"family": "Ermisch", "given": "J\u00f6rg", "initials": "J"}, {"family": "Berger", "given": "Luisa", "initials": "L"}, {"family": "Schroth", "given": "Stefanie", "initials": "S"}, {"family": "Isermann", "given": "Berend", "initials": "B"}, {"family": "Borte", "given": "Stephan", "initials": "S"}, {"family": "Biemann", "given": "Ronald", "initials": "R"}], "type": "journal article", "published": "2020-11-05", "journal": {"title": "Clin Chim Acta", "issn": "1873-3492", "volume": null, "issue": null, "issn-l": "0009-8981"}, "abstract": "Serological severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody assays differ in the target antigen specificity, e.g. of antibodies directed against the viral spike or the nucleocapsid protein, and in the spectrum of detected immunoglobulins. The aim of the study was to evaluate the performance of two different routinely used immunoassays in hospitalized and outpatient COVID-19 cases.\n\nThe test characteristics of commercially available spike1 protein-based serological assays (Euroimmun, EI-assays), determining IgA or IgG and nucleocapsid-based assays (Virotech, VT-assays) determining IgA, IgM or IgG were compared in 139 controls and 116 hospitalized and outpatient COVID-19 cases.\n\nHospitalized COVID-19 patients (n = 51; 115 samples) showed significantly higher concentrations of antibodies against SARS-CoV-2 and differed from outpatient cases (n = 65) by higher age, higher disease severity scores and earlier follow up blood sampling. Sensitivity of the two IgG assays was comparable in hospitalized patients tested \u2265 14 days (EI-assay: 88%, CI 95% 67.6-99.9; VT-assay: 96%, CI95% 77.7-99.8). In outpatient COVID-19 cases sensitivity was significantly lower in the VT-assay (86.2%, CI95% 74.8-93.1) compared with the EI-assay (98.5%, CI95% 90.6-99.9). Assays for IgA and IgM demonstrated a lack of specificity or sensitivity.\n\nOur results indicate that SARS-CoV-2 serological assays may need to be optimized to produce reliable results in outpatient COVID-19 cases who are low or even asymptomatic. Assays for IgA and IgM have limited diagnostic performance and do not prove an additional value for population-based screening approaches.", "doi": "10.1016/j.cca.2020.10.035", "pmid": "33159952", "labels": {"Type: Journal article": null, "Category: Serology": null}, "xrefs": [{"db": "pii", "key": "S0009-8981(20)30517-9"}, {"db": "pmc", "key": "PMC7642750"}], "notes": [], "created": "2020-11-27T10:07:09.483Z", "modified": "2021-02-26T08:46:49.385Z"}, {"entity": "publication", "iuid": "0415d3631d304d8fbf5b049b0b57dc4f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0415d3631d304d8fbf5b049b0b57dc4f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0415d3631d304d8fbf5b049b0b57dc4f"}}, "title": "Changes in Tinnitus Experiences During the COVID-19 Pandemic.", "authors": [{"family": "Beukes", "given": "Eldr\u00e9 W", "initials": "EW"}, {"family": "Baguley", "given": "David M", "initials": "DM"}, {"family": "Jacquemin", "given": "Laure", "initials": "L"}, {"family": "Lourenco", "given": "Matheus P C G", "initials": "MPCG"}, {"family": "Allen", "given": "Peter M", "initials": "PM"}, {"family": "Onozuka", "given": "Joy", "initials": "J"}, {"family": "Stockdale", "given": "David", "initials": "D"}, {"family": "Kaldo", "given": "Viktor", "initials": "V"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Manchaiah", "given": "Vinaya", "initials": "V"}], "type": "journal article", "published": "2020-11-05", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "592878", "issn-l": "2296-2565"}, "abstract": "Introduction: The COVID-19 pandemic has disrupted delivery of healthcare, economic activity, and affected social interactions. Identifying and supporting those most affected by the pandemic is required. The purpose of this study was to determine the impact of the pandemic on individuals with tinnitus and to identify mediating factors. Methods: This is a mixed-methods exploratory cross-sectional study, using data collected via an online survey from 3,103 individuals with tinnitus from 48 countries. The greatest representation was from North America (49%) and Europe (47%) and other countries were only marginally represented. Results: Although the study was aimed at those with pre-existing tinnitus, 7 individuals reported having COVID-19 initiated tinnitus. Having COVID-19 symptoms exacerbated tinnitus in 40% of respondents, made no change in 54%, and improved tinnitus in 6%. Other mediating factors such as the social and emotional consequences of the pandemic made pre-existing tinnitus more bothersome for 32% of the respondents, particularly for females and younger adults, better for 1%, and caused no change to tinnitus for 67%. Pre-existing tinnitus was significantly exacerbated for those self-isolating, experiencing loneliness, sleeping poorly, and with reduced levels of exercise. Increased depression, anxiety, irritability, and financial worries further significantly contributed to tinnitus being more bothersome during the pandemic period. Conclusions: These findings have implications for tinnitus management, because they highlight the diverse response both internal and external factors have on tinnitus levels. Clinical services should be mindful that tinnitus may be caused by contracting COVID-19 and pre-existing tinnitus may be exacerbated, although in the majority of respondents there was no change. Additional support should be offered where tinnitus severity has increased due to the health, social, and/or emotional effects of the COVID-19 pandemic. Tinnitus may be more bothersome for those experiencing loneliness, having fewer social interactions, and who are more anxious or worried.", "doi": "10.3389/fpubh.2020.592878", "pmid": "33251179", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7676491"}], "notes": [], "created": "2020-12-03T08:25:37.374Z", "modified": "2021-02-26T08:45:47.798Z"}, {"entity": "publication", "iuid": "8b254ae76f9b47aabd6eea4864698cc3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b254ae76f9b47aabd6eea4864698cc3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b254ae76f9b47aabd6eea4864698cc3"}}, "title": "COVID-19 and misinformation: Is censorship of social media a remedy to the spread of medical misinformation?", "authors": [{"family": "Niemiec", "given": "Emilia", "initials": "E"}], "type": "journal article", "published": "2020-11-05", "journal": {"title": "EMBO Rep", "issn": "1469-3178", "volume": "21", "issue": "11", "pages": "e51420", "issn-l": null}, "abstract": "Social media companies have resorted to censorship to suppress misinformation about the COVID-19 pandemic. This is not the most prudent solution though given the uncertainties about the disease.", "doi": "10.15252/embr.202051420", "pmid": "33103289", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7645258"}], "notes": [], "created": "2020-12-01T15:26:00.457Z", "modified": "2020-12-01T15:26:15.906Z"}, {"entity": "publication", "iuid": "2caee507b4b1417aaf5e5dde8f795031", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2caee507b4b1417aaf5e5dde8f795031.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2caee507b4b1417aaf5e5dde8f795031"}}, "title": "The impact of the early phase of the COVID-19 pandemic on mental-health services in Europe.", "authors": [{"family": "Thome", "given": "Johannes", "initials": "J"}, {"family": "Deloyer", "given": "Jocelyn", "initials": "J"}, {"family": "Coogan", "given": "Andrew N", "initials": "AN"}, {"family": "Bailey-Rodriguez", "given": "Deborah", "initials": "D"}, {"family": "da Cruz E Silva", "given": "Odete A B", "initials": "OAB"}, {"family": "Faltraco", "given": "Frank", "initials": "F"}, {"family": "Grima", "given": "Cathleen", "initials": "C"}, {"family": "Gudjonsson", "given": "Snaebjorn Omar", "initials": "SO"}, {"family": "Hanon", "given": "Cecile", "initials": "C"}, {"family": "Holl\u00fd", "given": "Martin", "initials": "M"}, {"family": "Joosten", "given": "Jo", "initials": "J"}, {"family": "Karlsson", "given": "Ingegerd", "initials": "I"}, {"family": "Kelemen", "given": "Gabriela", "initials": "G"}, {"family": "Korman", "given": "Maria", "initials": "M"}, {"family": "Krysta", "given": "Krzysztof", "initials": "K"}, {"family": "Lichterman", "given": "Boleslav", "initials": "B"}, {"family": "Loganovsky", "given": "Konstantin", "initials": "K"}, {"family": "Marazziti", "given": "Donatella", "initials": "D"}, {"family": "Maraitou", "given": "Margarita", "initials": "M"}, {"family": "Mertens de Wilmars", "given": "Serge", "initials": "S"}, {"family": "Reunamen", "given": "Merja", "initials": "M"}, {"family": "Rexhaj", "given": "Shyhrete", "initials": "S"}, {"family": "Sancaktar", "given": "Muhammet", "initials": "M"}, {"family": "Sempere", "given": "Javier", "initials": "J"}, {"family": "Tournier", "given": "Isabelle", "initials": "I"}, {"family": "Weynant", "given": "Emilie", "initials": "E"}, {"family": "Vis", "given": "Christiaan", "initials": "C"}, {"family": "Lebas", "given": "Marie-Clotilde", "initials": "MC"}, {"family": "Fond-Harmant", "given": "Laurence", "initials": "L"}], "type": "journal article", "published": "2020-11-04", "journal": {"title": "World J Biol Psychiatry", "issn": "1814-1412", "volume": null, "issue": null, "pages": "1-15", "issn-l": null}, "abstract": "The current COVID-19 pandemic confronts psychiatric patients and mental health services with unique and severe challenges. In order to identify these trans-national challenges across Europe, an ad-hoc survey was conducted among 23 experts, each answering for one European or aligned country. A number of important themes and issues were raised for the impact of COVID-19 on mental health and mental health services, barriers to service provision and future consequences. A number of key issues were reported by colleagues across several jurisdictions, even though these were at different stages of their national epidemics. Based on these findings, we articulate some important learnings from the early stages of the COVID-19 European pandemic, and highlight key considerations for all countries' mental health services as the current pandemic develops and for future pandemics.", "doi": "10.1080/15622975.2020.1844290", "pmid": "33143529", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-01T14:50:54.093Z", "modified": "2020-12-01T14:50:54.114Z"}, {"entity": "publication", "iuid": "708edd457cd5407da90e7a672b55b849", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/708edd457cd5407da90e7a672b55b849.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/708edd457cd5407da90e7a672b55b849"}}, "title": "Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2", "authors": [{"family": "Cust\u00f3dio", "given": "T\u00e2nia F", "initials": "TF"}, {"family": "Das", "given": "Hrishikesh", "initials": "H"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Pazicky", "given": "Samuel", "initials": "S"}, {"family": "Pieprzyk", "given": "Joanna", "initials": "J"}, {"family": "Sorgenfrei", "given": "Mich\u00e8le", "initials": "M"}, {"family": "Schroer", "given": "Martin A", "initials": "MA"}, {"family": "Gruzinov", "given": "Andrey Yu", "initials": "AY"}, {"family": "Jeffries", "given": "Cy M", "initials": "CM"}, {"family": "Graewert", "given": "Melissa A", "initials": "MA"}, {"family": "Svergun", "given": "Dmitri I", "initials": "DI"}, {"family": "Dobrev", "given": "Nikolay", "initials": "N"}, {"family": "Remans", "given": "Kim", "initials": "K"}, {"family": "Seeger", "given": "Markus A", "initials": "MA"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "H\u00e4llberg", "given": "B Martin", "initials": "BM"}, {"family": "L\u00f6w", "given": "Christian", "initials": "C"}], "type": "journal-article", "published": "2020-11-04", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "11", "issue": "1", "pages": null}, "abstract": "The coronavirus SARS-CoV-2 is the cause of the ongoing COVID-19 pandemic. Therapeutic neutralizing antibodies constitute a key short-to-medium term approach to tackle COVID-19. However, traditional antibody production is hampered by long development times and costly production. Here, we report the rapid isolation and characterization of nanobodies from a synthetic library, known as sybodies (Sb), that target the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein. Several binders with low nanomolar affinities and efficient neutralization activity were identified of which Sb23 displayed high affinity and neutralized pseudovirus with an IC50 of 0.6\u2009\u00b5g/ml. A cryo-EM structure of the spike bound to Sb23 showed that Sb23 binds competitively in the ACE2 binding site. Furthermore, the cryo-EM reconstruction revealed an unusual conformation of the spike where two RBDs are in the \u2018up\u2019 ACE2-binding conformation. The combined approach represents an alternative, fast workflow to select binders with neutralizing activity against newly emerging viruses.", "doi": "10.1038/s41467-020-19204-y", "pmid": "33149112", "labels": {"Type: Journal article": null, "Funder: VR": null, "Research Area: Host cell systems biology and targets": null, "Funder: H2020": null, "Funder: KAW/SciLifeLab": null, "Category: Biochemistry": null, "Category: Other": null, "Category: Proteins": null}, "xrefs": [{"db": "URL", "key": "https://github.com/tania-custodio/Sb23", "description": "Github: MST and BLI data"}, {"db": "URL", "key": "https://www.sasbdb.org/data/SASDJF4/", "description": "SASBDB SASDJF4: Synthetic nanobody Sybody 23 (Sy23)"}, {"db": "URL", "key": "https://www.sasbdb.org/data/SASDJG4/", "description": "SASBDB SASDJG4: SARS-CoV-2 spike protein ACE2 receptor binding domain (RBD)"}, {"db": "URL", "key": "https://www.sasbdb.org/data/SASDJH4/", "description": "SASBDB SASDJH4: SARS-CoV-2 spike protein ACE2 receptor binding domain (RBD) bound to the synthetic nanobody Sybody 23 (Sy23)"}, {"db": "PDB", "key": "7A25", "description": "Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing sybodies (Sb23) (1-up)"}, {"db": "PDB", "key": "7A29", "description": "Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing sybodies (Sb23) (2-up)"}, {"db": "URL", "key": "https://www.ebi.ac.uk/pdbe/entry/emdb/EMD-11617", "description": "EMDB EMD-11617: Cryo-EM density maps of SARS-CoV-2 spike glycoprotein with Sb23 bound (2-up)"}, {"db": "URL", "key": "https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-020-19204-y/MediaObjects/41467_2020_19204_MOESM4_ESM.pdf", "description": "Sequences of all the selected sybodies from the study"}], "notes": [], "created": "2020-11-10T10:40:14.648Z", "modified": "2021-06-13T14:17:49.316Z"}, {"entity": "publication", "iuid": "ab683807584e43508e269e9580f7d3ac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ab683807584e43508e269e9580f7d3ac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ab683807584e43508e269e9580f7d3ac"}}, "title": "Innate lymphoid cell composition associates with COVID-19 disease severity", "authors": [{"family": "Garc\u00eda", "given": "Marina", "initials": "M"}, {"family": "Kokkinou", "given": "Efthymia", "initials": "E"}, {"family": "Carrasco Garc\u00eda", "given": "Anna", "initials": "A"}, {"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Palma Medina", "given": "Laura M.", "initials": "LM"}, {"family": "Maleki", "given": "Kimia T.", "initials": "KT"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Varnait\u0117", "given": "Renata", "initials": "R"}, {"family": "Filipovic", "given": "Iva", "initials": "I"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K.", "initials": "NK"}, {"family": "Folkesson", "given": "Elin", "initials": "E"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Eriksson", "given": "Lars I.", "initials": "LI"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J"}, {"family": "Group", "given": "the Karolinska KI/K COVID-19 Study", "initials": "tKKCS"}], "type": "posted-content", "published": "2020-11-04", "journal": {"title": "Clin Transl Immunol", "issn": "2050-0068", "issn-l": null, "volume": "9", "issue": "12", "pages": null}, "abstract": "Objectives The role of innate lymphoid cells (ILCs) in coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is unknown. Understanding the immune response in COVID-19 could contribute to unravel the pathogenesis and identification of treatment targets. To describe the phenotypic landscape of circulating ILCs in COVID-19 patients and to identify ILC phenotypes correlated to serum biomarkers, clinical markers, and laboratory parameters relevant in COVID-19.\r\n\r\nMethods Blood samples collected from moderately (n=11) and severely ill (n=12) COVID-19 patients as well as healthy control donors (n=16), were analyzed with 18-parameter flow cytometry. Using supervised and unsupervised approaches, we examined the ILC activation status and homing profile. Clinical and laboratory parameters were obtained from all COVID-19 patients and serum biomarkers were analyzed with multiplex immunoassays.\r\n\r\nResults ILCs were largely depleted from the circulation of COVID-19 patients compared with healthy controls. Remaining circulating ILCs from patients revealed increased frequencies of ILC2 in moderate COVID-19, with a concomitant decrease of ILC precursors (ILCp), as compared with controls. ILC2 and ILCp showed an activated phenotype with increased CD69 expression, whereas expression levels of the chemokine receptors CXCR3 and CCR4 were significantly altered in ILC2 and ILCp, and ILC1, respectively. The activated ILC profile of COVID-19 patients was associated with soluble inflammatory markers, while frequencies of ILC subsets were correlated with laboratory parameters that reflect the disease severity.\r\n\r\nConclusion This study provides insights into the potential role of ILCs in immune responses against SARS-CoV-2, particularly linked to the severity of COVID-19.", "doi": "10.1002/cti2.1224", "pmid": "33343897", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://covid19cellatlas.com/#/", "description": "Karolinska KI/K Covid19 Immune atlas"}], "notes": [], "created": "2020-11-04T14:24:06.108Z", "modified": "2021-06-13T14:18:39.784Z"}, {"entity": "publication", "iuid": "2ba162b83ed44bdcb5738acf41b3156e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ba162b83ed44bdcb5738acf41b3156e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ba162b83ed44bdcb5738acf41b3156e"}}, "title": "Global between-countries variance in SARS-CoV-2 mortality is driven by reported prevalence, age distribution, and case detection rate", "authors": [{"family": "Baba\u010di\u0107", "given": "Haris", "initials": "H"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J"}, {"family": "Pernemalm", "given": "Maria", "initials": "M"}], "type": null, "published": "2020-11-04", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Objective: To explain the global between-countries variance in number of deaths per million citizens (nDpm) and case fatality rate (CFR) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Design: Systematic analysis. Data sources: Worldometer, European Centre for Disease Prevention and Control, United Nations Main outcome measures: The explanators of nDpm and CFR were mathematically hypothesised and tested on publicly-available data from 88 countries with linear regression models on May 1st 2020. The derived explanators - age-adjusted infection fatality rate (IFRadj) and case detection rate (CDR) - were estimated for each country based on a SARS-CoV-2 model of China. The accuracy and agreement of the models with observed data was assessed with R2 and Bland-Altman plots, respectively. Sensitivity analyses involved removal of outliers and testing the models at five retrospective and two prospective time points. Results: Globally, IFRadj estimates varied between countries, ranging from below 0.2% in the youngest nations, to above 1.3% in Portugal, Greece, Italy, and Japan. The median estimated global CDR of SARS-CoV-2 infections on April 16th 2020 was 12.9%, suggesting that most of the countries have a much higher number of cases than reported. At least 93% and up to 99% of the variance in nDpm was explained by reported prevalence expressed as cases per million citizens (nCpm), IFRadj, and CDR. IFRadj and CDR accounted for up to 97% of the variance in CFR, but this model was less reliable than the nDpm model, being sensitive to outliers (R2 as low as 67.5%). Conclusions: The current differences in SARS-CoV-2 mortality between countries are driven mainly by reported prevalence of infections, age distribution, and CDR. The nDpm might be a more stable estimate than CFR in comparing mortality burden between countries.", "doi": "10.1101/2020.05.28.20114934", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-04T15:42:54.004Z", "modified": "2021-02-26T08:45:47.974Z"}, {"entity": "publication", "iuid": "7a93d531baf34f3cbe335fcb17e935f8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a93d531baf34f3cbe335fcb17e935f8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a93d531baf34f3cbe335fcb17e935f8"}}, "title": "Circulating bioactive adrenomedullin as a marker of sepsis, septic shock and critical illness.", "authors": [{"family": "Lundberg", "given": "Oscar H M", "initials": "OHM"}, {"family": "Lengquist", "given": "Maria", "initials": "M"}, {"family": "Sp\u00e5ngfors", "given": "Martin", "initials": "M"}, {"family": "Annborn", "given": "Martin", "initials": "M"}, {"family": "Bergmann", "given": "Deborah", "initials": "D"}, {"family": "Schulte", "given": "Janin", "initials": "J"}, {"family": "Levin", "given": "Helena", "initials": "H"}, {"family": "Melander", "given": "Olle", "initials": "O"}, {"family": "Frigyesi", "given": "Attila", "initials": "A"}, {"family": "Friberg", "given": "Hans", "initials": "H"}], "type": "journal article", "published": "2020-11-04", "journal": {"title": "Crit Care", "issn": "1466-609X", "volume": "24", "issue": "1", "pages": "636", "issn-l": "1364-8535"}, "abstract": "Biomarkers can be of help to understand critical illness and to identify and stratify sepsis. Adrenomedullin is a vasoactive hormone, with reported prognostic and potentially therapeutic value in sepsis. The primary aim of this study was to investigate the association of circulating bioactive adrenomedullin (bio-ADM) levels at intensive care unit (ICU) admission with mortality in sepsis patients and in a general ICU population. Secondary aims included the association of bio-ADM with organ failure and the ability of bio-ADM to identify sepsis.\n\nIn this retrospective observational study, adult patients admitted to one of four ICUs during 2016 had admission bio-ADM levels analysed. Age-adjusted odds ratios (OR) with 95% CI for log-2 transformed bio-ADM, and Youden's index derived cut-offs were calculated. The primary outcome was 30-day mortality, and secondary outcomes included the need for organ support and the ability to identify sepsis.\n\nBio-ADM in 1867 consecutive patients were analysed; 632 patients fulfilled the sepsis-3 criteria of whom 267 had septic shock. The median bio-ADM in the entire ICU population was 40 pg/mL, 74 pg/mL in sepsis patients, 107 pg/mL in septic shock and 29 pg/mL in non-septic patients. The association of elevated bio-ADM and mortality in sepsis patients and the ICU population resulted in ORs of 1.23 (95% CI 1.07-1.41) and 1.22 (95% CI 1.12-1.32), respectively. The association with mortality remained after additional adjustment for lactate in sepsis patients. Elevated bio-ADM was associated with an increased need for dialysis with ORs of 2.28 (95% CI 2.01-2.59) and 1.97 (95% CI 1.64-2.36) for the ICU population and sepsis patients, respectively, and with increased need of vasopressors, OR 1.33 (95% CI 1.23-1.42) (95% CI 1.17-1.50) for both populations. Sepsis was identified with an OR of 1.78 (95% CI 1.64-1.94) for bio-ADM, after additional adjustment for severity of disease. A bio-ADM cut-off of 70 pg/mL differentiated between survivors and non-survivors in sepsis, but a Youden's index derived threshold of 108 pg/mL performed better.\n\nAdmission bio-ADM is associated with 30-day mortality and organ failure in sepsis patients as well as in a general ICU population. Bio-ADM may be a morbidity-independent sepsis biomarker.", "doi": "10.1186/s13054-020-03351-1", "pmid": "33148300", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7641835"}, {"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-12-02T18:20:01.327Z", "modified": "2021-02-26T08:45:48.358Z"}, {"entity": "publication", "iuid": "8cc0ac83572f4f3a9281eda66d0746a5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8cc0ac83572f4f3a9281eda66d0746a5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8cc0ac83572f4f3a9281eda66d0746a5"}}, "title": "Associations between mortality from COVID-19 in two Italian regions and outdoor air pollution as assessed through tropospheric nitrogen dioxide.", "authors": [{"family": "Filippini", "given": "Tommaso", "initials": "T"}, {"family": "Rothman", "given": "Kenneth J", "initials": "KJ"}, {"family": "Cocchio", "given": "Silvia", "initials": "S"}, {"family": "Narne", "given": "Elena", "initials": "E"}, {"family": "Mantoan", "given": "Domenico", "initials": "D"}, {"family": "Saia", "given": "Mario", "initials": "M"}, {"family": "Goffi", "given": "Alessia", "initials": "A"}, {"family": "Ferrari", "given": "Fabrizio", "initials": "F"}, {"family": "Maffeis", "given": "Giuseppe", "initials": "G"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}, {"family": "Baldo", "given": "Vincenzo", "initials": "V"}, {"family": "Vinceti", "given": "Marco", "initials": "M"}], "type": "journal article", "published": "2020-11-04", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "volume": "760", "issue": null, "pages": "143355", "issn-l": "0048-9697"}, "abstract": "After the appearance of COVID-19 in China last December 2019, Italy was the first European country to be severely affected by the outbreak. The first diagnosis in Italy was on February 20, 2020, followed by the establishment of a light and a tight lockdown on February 23 and on March 8, 2020, respectively. The virus spread rapidly, particularly in the North of the country in the 'Padan Plain' area, known as one of the most polluted regions in Europe. Air pollution has been recently hypothesized to enhance the clinical severity of SARS-CoV-2 infection, acting through adverse effects on immunity, induction of respiratory and other chronic disease, upregulation of viral receptor ACE-2, and possible pathogen transportation as a virus carrier. We investigated the association between air pollution and subsequent COVID-19 mortality rates within two Italian regions (Veneto and Emilia-Romagna). We estimated ground-level nitrogen dioxide through its tropospheric levels using data available from the Sentinel-5P satellites of the European Space Agency Copernicus Earth Observation Programme before the lockdown. We then examined COVID-19 mortality rates in relation to the nitrogen dioxide levels at three 14-day lag points after the lockdown, namely March 8, 22 and April 5, 2020. Using a multivariable negative binomial regression model, we found an association between nitrogen dioxide and COVID-19 mortality. Although ecological data provide only weak evidence, these findings indicate an association between air pollution levels and COVID-19 severity.", "doi": "10.1016/j.scitotenv.2020.143355", "pmid": "33187703", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(20)36886-8"}, {"db": "pmc", "key": "PMC7609227"}], "notes": [], "created": "2020-11-27T09:58:18.493Z", "modified": "2021-02-26T08:46:13.371Z"}, {"entity": "publication", "iuid": "16e615de9a304cc385f80806c47bc1fe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/16e615de9a304cc385f80806c47bc1fe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/16e615de9a304cc385f80806c47bc1fe"}}, "title": "Decision-making around admission to intensive care in the UK pre-COVID-19: a multicentre ethnographic study.", "authors": [{"family": "Griffiths", "given": "F", "initials": "F"}, {"family": "Svantesson", "given": "M", "initials": "M"}, {"family": "Bassford", "given": "C", "initials": "C"}, {"family": "Dale", "given": "J", "initials": "J"}, {"family": "Blake", "given": "C", "initials": "C"}, {"family": "McCreedy", "given": "A", "initials": "A"}, {"family": "Slowther", "given": "A-M", "initials": "AM"}], "type": "journal article", "published": "2020-11-03", "journal": {"title": "Anaesthesia", "issn": "1365-2044", "volume": null, "issue": null, "issn-l": "0003-2409"}, "abstract": "Predicting who will benefit from admission to an intensive care unit is not straightforward and admission processes vary. Our aim was to understand how decisions to admit or not are made. We observed 55 decision-making events in six NHS hospitals. We interviewed 30 referring and 43 intensive care doctors about these events. We describe the nature and context of the decision-making and analysed how doctors make intensive care admission decisions. Such decisions are complex with intrinsic uncertainty, often urgent and made with incomplete information. While doctors aspire to make patient-centred decisions, key challenges include: being overworked with lack of time; limited support from senior staff; and a lack of adequate staffing in other parts of the hospital that may be compromising patient safety. To reduce decision complexity, heuristic rules based on experience are often used to help think through the problem; for example, the patient's functional status or clinical gestalt. The intensive care doctors actively managed relationships with referring doctors; acted as the hospital generalist for acutely ill patients; and brought calm to crisis situations. However, they frequently failed to elicit values and preferences from patients or family members. They were rarely explicit in balancing burdens and benefits of intensive care for patients, so consistency and equity cannot be judged. The use of a framework for intensive care admission decisions that reminds doctors to seek patient or family views and encourages explicit balancing of burdens and benefits could improve decision-making. However, a supportive, adequately resourced context is also needed.", "doi": "10.1111/anae.15272", "pmid": "33141939", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-01T14:53:02.823Z", "modified": "2020-12-01T14:53:02.834Z"}, {"entity": "publication", "iuid": "fa9477a93058403489aaf9882b81d38a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa9477a93058403489aaf9882b81d38a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa9477a93058403489aaf9882b81d38a"}}, "title": "COVID-19 case-fatality rate and demographic and socioeconomic influencers: worldwide spatial regression analysis based on country-level data.", "authors": [{"family": "Cao", "given": "Yang", "initials": "Y", "orcid": "0000-0002-3552-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7594ca0fdf2d4f238ca04a788a405cdb.json"}}, {"family": "Hiyoshi", "given": "Ayako", "initials": "A"}, {"family": "Montgomery", "given": "Scott", "initials": "S", "orcid": "0000-0001-6328-5494", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/601e7c2c4fa3497d91a6cef8f39b404d.json"}}], "type": "journal article", "published": "2020-11-03", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "10", "issue": "11", "pages": "e043560"}, "abstract": "To investigate the influence of demographic and socioeconomic factors on the COVID-19 case-fatality rate (CFR) globally.\n\nPublicly available register-based ecological study.\n\nTwo hundred and nine countries/territories in the world.\n\nAggregated data including 10 445 656 confirmed COVID-19 cases.\n\nCOVID-19 CFR and crude cause-specific death rate were calculated using country-level data from the Our World in Data website.\n\nThe average of country/territory-specific COVID-19 CFR is about 2%-3% worldwide and higher than previously reported at 0.7%-1.3%. A doubling in size of a population is associated with a 0.48% (95% CI 0.25% to 0.70%) increase in COVID-19 CFR, and a doubling in the proportion of female smokers is associated with a 0.55% (95% CI 0.09% to 1.02%) increase in COVID-19 CFR. The open testing policies are associated with a 2.23% (95% CI 0.21% to 4.25%) decrease in CFR. The strictness of anti-COVID-19 measures was not statistically significantly associated with CFR overall, but the higher Stringency Index was associated with higher CFR in higher-income countries with active testing policies (regression coefficient beta=0.14, 95% CI 0.01 to 0.27). Inverse associations were found between cardiovascular disease death rate and diabetes prevalence and CFR.\n\nThe association between population size and COVID-19 CFR may imply the healthcare strain and lower treatment efficiency in countries with large populations. The observed association between smoking in women and COVID-19 CFR might be due to the finding that the proportion of female smokers reflected broadly the income level of a country. When testing is warranted and healthcare resources are sufficient, strict quarantine and/or lockdown measures might result in excess deaths in underprivileged populations. Spatial dependence and temporal trends in the data should be taken into account in global joint strategy and/or policy making against the COVID-19 pandemic.", "doi": "10.1136/bmjopen-2020-043560", "pmid": "33148769", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7640588"}, {"db": "pii", "key": "bmjopen-2020-043560"}], "notes": [], "created": "2020-11-27T10:09:42.512Z", "modified": "2023-06-19T14:35:50.521Z"}, {"entity": "publication", "iuid": "bfd1e58754834c7199f78cfb8051d92a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bfd1e58754834c7199f78cfb8051d92a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bfd1e58754834c7199f78cfb8051d92a"}}, "title": "The COVID-19 pandemic: How predictive analysis, artificial intelligence and GIS can be integrated into a clinical command system to improve disaster response and preparedness.", "authors": [{"family": "Hertelendy", "given": "Attila J", "initials": "AJ"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}, {"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}], "type": "letter", "published": "2020-11-02", "journal": {"title": "Am J Emerg Med", "issn": "1532-8171", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.ajem.2020.10.049", "pmid": "33160803", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0735-6757(20)30945-1"}, {"db": "pmc", "key": "PMC7605801"}], "notes": [], "created": "2020-12-01T14:23:39.044Z", "modified": "2020-12-01T14:23:55.056Z"}, {"entity": "publication", "iuid": "9115762056744c4eb68986440242c8dd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9115762056744c4eb68986440242c8dd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9115762056744c4eb68986440242c8dd"}}, "title": "Epidemiological and Clinical Characteristics of COVID-19 in Children: A Systematic Review and Meta-Analysis.", "authors": [{"family": "Li", "given": "Bingbing", "initials": "B"}, {"family": "Zhang", "given": "Shan", "initials": "S"}, {"family": "Zhang", "given": "Ruili", "initials": "R"}, {"family": "Chen", "given": "Xi", "initials": "X"}, {"family": "Wang", "given": "Yong", "initials": "Y"}, {"family": "Zhu", "given": "Changlian", "initials": "C"}], "type": "systematic review", "published": "2020-11-02", "journal": {"title": "Front Pediatr", "issn": "2296-2360", "volume": "8", "issue": null, "pages": "591132", "issn-l": "2296-2360"}, "abstract": "Given the relatively low rate and limited publicly available data regarding children with SARS-CoV-2 infection, this knowledge gap should be addressed with urgency. This systematic review with meta-analysis aimed to evaluate the epidemiological spectrum and clinical characteristics of children infected with SARS-CoV-2. Relevant international and Chinese public databases were systematically searched to identify all case studies from January 1, 2020 to May 7, 2020. This study consisted of 96 studies involving 7004 cases. The mean age of pediatric cases was 6.48 years (95% CI 52.0-77.5), 90% had household contact, and 66% presented with mild to moderate clinical syndromes. The main symptoms were fever (47%, 95% CI 41-53%) and cough (42%, 95% CI 36-48%). About 23% of children were asymptomatic, 27% had comorbidity, and 29% had a co-infection. The pooled mean incubation period was 9.57 days (95% CI 7.70-11.44). The shedding of SARS-CoV-2 in the upper respiratory tract lasted 11.43 days, and 75% of patients had virus particles in their stool. A total of 34% of the children had neutropenia and 26% had lymphocytosis. Interferon-alpha (81%) was the most commonly used antiviral drug in the children. The discharge and death rates were 79 and 1%. In conclusion, the transmissibility of pediatric COVID-19 should be not ignored because of the relatively long incubation period, shedding duration, and mild clinical syndromes.", "doi": "10.3389/fped.2020.591132", "pmid": "33224909", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7667131"}], "notes": [], "created": "2020-11-26T12:32:45.094Z", "modified": "2020-11-26T12:32:45.103Z"}, {"entity": "publication", "iuid": "28640e6c60bf474198a68db6a0463bf6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/28640e6c60bf474198a68db6a0463bf6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/28640e6c60bf474198a68db6a0463bf6"}}, "title": "Expansion of SARS-CoV-2-Specific Antibody-Secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients.", "authors": [{"family": "Varnait\u0117", "given": "Renata", "initials": "R", "orcid": "0000-0001-9391-9291", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05a03781d1c84aad85895298c193c575.json"}}, {"family": "Garc\u00eda", "given": "Marina", "initials": "M", "orcid": "0000-0002-9130-3933", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c5b109d7a54e4c05a48e0f21c4432be6.json"}}, {"family": "Glans", "given": "Hedvig", "initials": "H", "orcid": "0000-0002-7401-2245", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ffccfdfb5ffa4d09ab2ae87655f30585.json"}}, {"family": "Maleki", "given": "Kimia T", "initials": "KT", "orcid": "0000-0001-5382-5477", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c0313be527f49c0b41a37115a68408d.json"}}, {"family": "Sandberg", "given": "John Tyler", "initials": "JT", "orcid": "0000-0001-6747-6933", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dfe4b6f5f2f24420bd78d7ae9b71e2d4.json"}}, {"family": "Tynell", "given": "Janne", "initials": "J"}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2f2dc27d02294a15a6f691be6aab641f.json"}}, {"family": "Lagerqvist", "given": "Nina", "initials": "N"}, {"family": "Asgeirsson", "given": "Hilmir", "initials": "H", "orcid": "0000-0003-3869-8021", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/870e3520475b41f8a4f39744b1ecb3ea.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG", "orcid": "0000-0003-0908-7387", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48a59f01e46c41038301a586178e8e2a.json"}}, {"family": "Ahl\u00e9n", "given": "Gustaf", "initials": "G"}, {"family": "Frelin", "given": "Lars", "initials": "L"}, {"family": "S\u00e4llberg", "given": "Matti", "initials": "M"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S", "orcid": "0000-0002-2446-4323", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/363ff940d9c64575a11bd45372927b2c.json"}}], "type": "journal article", "published": "2020-11-01", "journal": {"title": "J Immunol", "issn": "1550-6606", "issn-l": null, "volume": "205", "issue": "9", "pages": "2437-2446"}, "abstract": "Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in late 2019 and has since become a global pandemic. Pathogen-specific Abs are typically a major predictor of protective immunity, yet human B cell and Ab responses during COVID-19 are not fully understood. In this study, we analyzed Ab-secreting cell and Ab responses in 20 hospitalized COVID-19 patients. The patients exhibited typical symptoms of COVID-19 and presented with reduced lymphocyte numbers and increased T cell and B cell activation. Importantly, we detected an expansion of SARS-CoV-2 nucleocapsid protein-specific Ab-secreting cells in all 20 COVID-19 patients using a multicolor FluoroSpot Assay. Out of the 20 patients, 16 had developed SARS-CoV-2-neutralizing Abs by the time of inclusion in the study. SARS-CoV-2-specific IgA, IgG, and IgM Ab levels positively correlated with SARS-CoV-2-neutralizing Ab titers, suggesting that SARS-CoV-2-specific Ab levels may reflect the titers of neutralizing Abs in COVID-19 patients during the acute phase of infection. Last, we showed that IL-6 and C-reactive protein serum concentrations were higher in patients who were hospitalized for longer, supporting the recent observations that IL-6 and C-reactive protein could be used as markers for COVID-19 severity. Altogether, this study constitutes a detailed description of clinical and immunological parameters in 20 COVID-19 patients, with a focus on B cell and Ab responses, and describes tools to study immune responses to SARS-CoV-2 infection and vaccination.", "doi": "10.4049/jimmunol.2000717", "pmid": "32878912", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC7576114"}, {"db": "pii", "key": "jimmunol.2000717"}], "notes": [], "created": "2020-11-04T14:50:45.425Z", "modified": "2023-06-19T14:32:55.754Z"}, {"entity": "publication", "iuid": "5f5f0603074945a8bcfdfbded42b74f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5f5f0603074945a8bcfdfbded42b74f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5f5f0603074945a8bcfdfbded42b74f9"}}, "title": "Addressing Healthcare Gaps in Sweden during the COVID-19 Outbreak: On Community Outreach and Empowering Ethnic Minority Groups in a Digitalized Context.", "authors": [{"family": "Valeriani", "given": "Giuseppe", "initials": "G"}, {"family": "Sarajlic Vukovic", "given": "Iris", "initials": "I"}, {"family": "Lindegaard", "given": "Tomas", "initials": "T"}, {"family": "Felizia", "given": "Roberto", "initials": "R"}, {"family": "Mollica", "given": "Richard", "initials": "R"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}], "type": "journal article", "published": "2020-11-01", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "volume": "8", "issue": "4", "issn-l": null}, "abstract": "Since its early stages, the COVID-19 pandemic has interacted with existing divides by ethnicity and socioeconomic statuses, exacerbating further inequalities in high-income countries. The Swedish public health strategy, built on mutual trust between the government and the society and giving the responsibility to the individual, has been criticized for not applying a dedicated and more diverse strategy for most disadvantaged migrants in dealing with the pandemic. In order to mitigate the unequal burden on the marginalized members of society, increasing efforts have been addressed to digital health technologies. Despite the strong potential of providing collective public health benefits, especially in a highly digitalized context as Sweden, need for a stronger cooperation between the public health authorities and migrant community leaders, representatives of migrant associations, religious leaders and other influencers of disadvantaged groups has emerged. Suggestions are presented on more culturally congruent, patient-centered health care services aimed to empower people to participate in a more effective public health response to the COVID-19 crisis.", "doi": "10.3390/healthcare8040445", "pmid": "33139619", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "healthcare8040445"}], "notes": [], "created": "2020-12-01T14:56:27.725Z", "modified": "2020-12-01T14:56:27.749Z"}, {"entity": "publication", "iuid": "f34afa2a75de4523ae268c8024729da5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f34afa2a75de4523ae268c8024729da5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f34afa2a75de4523ae268c8024729da5"}}, "title": "Work at inpatient care units is associated with an increased risk of SARS-CoV-2 infection; a cross-sectional study of 8679 healthcare workers in Sweden.", "authors": [{"family": "Lidstr\u00f6m", "given": "Anna-Karin", "initials": "AK"}, {"family": "Sund", "given": "Fredrik", "initials": "F"}, {"family": "Albinsson", "given": "Bo", "initials": "B"}, {"family": "Lindb\u00e4ck", "given": "Johan", "initials": "J"}, {"family": "Westman", "given": "Gabriel", "initials": "G"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "volume": "125", "issue": "4", "pages": "305-310", "issn-l": "0300-9734"}, "abstract": "During the Covid-19 pandemic, the protection of healthcare workers has been in focus throughout the world, but the availability and quality of personal protective equipment has at times and in some settings been suboptimal.\n\nA total of 8679 healthcare workers and healthcare support staff in the county of Uppsala, north of Stockholm, were included in this cross-sectional study. All subjects were analysed for IgG anti-SARS-CoV-2, and predictors for positive serostatus were analysed in a logistic regression model including demographic parameters and self-reported employment characteristics.\n\nOverall, 577 (6.6%) were classified as seropositive, with no statistically significant differences between healthcare workers and support staff. Among healthcare workers, age (OR 0.987 per year, 95% CI 0.980-0.995), time to sampling (OR 1.019 per day, 95% CI 1.004-1.035), and employment at an outpatient care unit (OR 0.620, 95% CI 0.487-0.788) were statistically significantly associated with risk of infection. Covid-19 specific units were not at particular risk, compared to other units with comparable characteristics and staff demography.\n\nOur findings indicate that SARS-CoV-2 transmission is related to inpatient healthcare work, and illustrate the need for a high standard of basic hygiene routines in all inpatient care settings.", "doi": "10.1080/03009734.2020.1793039", "pmid": "32684119", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7594729"}], "notes": [], "created": "2020-11-18T17:32:37.256Z", "modified": "2021-02-26T08:45:48.851Z"}, {"entity": "publication", "iuid": "bdb516f3c98f4f7098054985e3b15024", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bdb516f3c98f4f7098054985e3b15024.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bdb516f3c98f4f7098054985e3b15024"}}, "title": "Will coronavirus disease (COVID-19) have an impact on antimicrobial resistance?", "authors": [{"family": "Monnet", "given": "Dominique L", "initials": "DL"}, {"family": "Harbarth", "given": "Stephan", "initials": "S"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "45", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.45.2001886", "pmid": "33183403", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7667630"}], "notes": [], "created": "2020-11-30T16:27:06.332Z", "modified": "2020-11-30T16:27:06.344Z"}, {"entity": "publication", "iuid": "884d64d5e3ab4443b5b428260d57c4e9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/884d64d5e3ab4443b5b428260d57c4e9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/884d64d5e3ab4443b5b428260d57c4e9"}}, "title": "Virological surveillance of influenza viruses in the WHO European Region in 2019/20 - impact of the COVID-19 pandemic.", "authors": [{"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "Pereyaslov", "given": "Dmitriy", "initials": "D"}, {"family": "Hungnes", "given": "Olav", "initials": "O"}, {"family": "Prosenc", "given": "Katarina", "initials": "K"}, {"family": "Alm", "given": "Erik", "initials": "E"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Fielding", "given": "James", "initials": "J"}, {"family": "Sneiderman", "given": "Miriam", "initials": "M"}, {"family": "Martinuka", "given": "Oksana", "initials": "O"}, {"family": "Celentano", "given": "Lucia Pastore", "initials": "LP"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "WHO European Region influenza surveillance network", "given": "", "initials": ""}, {"family": "WHO European Region Influenza Surveillance Network author list", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "25", "issue": "46", "pages": null}, "abstract": "The COVID-19 pandemic negatively impacted the 2019/20 WHO European Region influenza surveillance. Compared with previous 4-year averages, antigenic and genetic characterisations decreased by 17% (3,140 vs 2,601) and 24% (4,474 vs 3,403). Of subtyped influenza A viruses, 56% (26,477/47,357) were A(H1)pdm09, 44% (20,880/47,357) A(H3). Of characterised B viruses, 98% (4,585/4,679) were B/Victoria. Considerable numbers of viruses antigenically differed from northern hemisphere vaccine components. In 2020/21, maintaining influenza virological surveillance, while supporting SARS-CoV-2 surveillance is crucial.", "doi": "10.2807/1560-7917.ES.2020.25.46.2001822", "pmid": "33213683", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7678039"}], "notes": [], "created": "2020-11-30T16:03:50.371Z", "modified": "2021-02-26T08:45:48.443Z"}, {"entity": "publication", "iuid": "cdca526a6b5d44c985559cb88dbd3572", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cdca526a6b5d44c985559cb88dbd3572.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cdca526a6b5d44c985559cb88dbd3572"}}, "title": "Using an integrated social cognition model to predict COVID-19 preventive behaviours.", "authors": [{"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Imani", "given": "Vida", "initials": "V"}, {"family": "Majd", "given": "Nilofar Rajabi", "initials": "NR"}, {"family": "Ghasemi", "given": "Zahra", "initials": "Z"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Hamilton", "given": "Kyra", "initials": "K"}, {"family": "Hagger", "given": "Martin S", "initials": "MS"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Br J Health Psychol", "issn": "2044-8287", "issn-l": null, "volume": "25", "issue": "4", "pages": "981-1005"}, "abstract": "Rates of novel coronavirus disease 2019 (COVID-19) infections have rapidly increased worldwide and reached pandemic proportions. A suite of preventive behaviours have been recommended to minimize risk of COVID-19 infection in the general population. The present study utilized an integrated social cognition model to explain COVID-19 preventive behaviours in a sample from the Iranian general population.\r\n\r\nThe study adopted a three-wave prospective correlational design.\r\n\r\nMembers of the general public (N = 1,718, M age = 33.34, SD = 15.77, male = 796, female = 922) agreed to participate in the study. Participants completed self-report measures of demographic characteristics, intention, attitude, subjective norm, perceived behavioural control, and action self-efficacy at an initial data collection occasion. One week later, participants completed self-report measures of maintenance self-efficacy, action planning and coping planning, and, a further week later, measures of COVID-19 preventive behaviours. Hypothesized relationships among social cognition constructs and COVID-19 preventive behaviours according to the proposed integrated model were estimated using structural equation modelling.\r\n\r\nThe proposed model fitted the data well according to multiple goodness-of-fit criteria. All proposed relationships among model constructs were statistically significant. The social cognition constructs with the largest effects on COVID-19 preventive behaviours were coping planning (\u03b2 = .575, p < .001) and action planning (\u03b2 = .267, p < .001).\r\n\r\nCurrent findings may inform the development of behavioural interventions in health care contexts by identifying intervention targets. In particular, findings suggest targeting change in coping planning and action planning may be most effective in promoting participation in COVID-19 preventive behaviours. Statement of contribution What is already known on this subject? Curbing COVID-19 infections globally is vital to reduce severe cases and deaths in at-risk groups. Preventive behaviours like handwashing and social distancing can stem contagion of the coronavirus. Identifying modifiable correlates of COVID-19 preventive behaviours is needed to inform intervention. What does this study add? An integrated model identified predictors of COVID-19 preventive behaviours in Iranian residents. Prominent predictors were intentions, planning, self-efficacy, and perceived behavioural control. Findings provide insight into potentially modifiable constructs that interventions can target. Research should examine if targeting these factors lead to changes in COVID-19 behaviours over time.", "doi": "10.1111/bjhp.12465", "pmid": "32780891", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7436576"}], "notes": [], "created": "2020-12-07T13:30:27.584Z", "modified": "2022-11-09T08:30:26.489Z"}, {"entity": "publication", "iuid": "040f98cfd40d407c994d51d6edbcc285", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/040f98cfd40d407c994d51d6edbcc285.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/040f98cfd40d407c994d51d6edbcc285"}}, "title": "The challenge of COVID-19 and hematopoietic cell transplantation; EBMT recommendations for management of hematopoietic cell transplant recipients, their donors, and patients undergoing CAR T-cell therapy.", "authors": [{"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Mikulska", "given": "Malgorzata", "initials": "M"}, {"family": "de la Camara", "given": "Rafael", "initials": "R"}, {"family": "Basak", "given": "Grzegorz W", "initials": "GW"}, {"family": "Chabannon", "given": "Christian", "initials": "C"}, {"family": "Corbacioglu", "given": "Selim", "initials": "S"}, {"family": "Duarte", "given": "Rafael", "initials": "R"}, {"family": "Dolstra", "given": "Harry", "initials": "H"}, {"family": "Lankester", "given": "Arjan C", "initials": "AC"}, {"family": "Mohty", "given": "Mohamad", "initials": "M"}, {"family": "Montoto", "given": "Silvia", "initials": "S"}, {"family": "Murray", "given": "John", "initials": "J"}, {"family": "Peffault de Latour", "given": "R\u00e9gis", "initials": "R"}, {"family": "Snowden", "given": "John A", "initials": "JA"}, {"family": "Yakoub-Agha", "given": "Ibrahim", "initials": "I"}, {"family": "Verhoeven", "given": "Bregje", "initials": "B"}, {"family": "Kr\u00f6ger", "given": "Nicolaus", "initials": "N"}, {"family": "Styczynski", "given": "Jan", "initials": "J"}, {"family": "European Society for Blood and Marrow Transplantation", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Bone Marrow Transplant", "issn": "1476-5365", "volume": "55", "issue": "11", "pages": "2071-2076", "issn-l": "0268-3369"}, "abstract": "The new coronavirus SARS-CoV-2 has rapidly spread over the world causing the disease by WHO called COVID-19. This pandemic poses unprecedented stress on the health care system including programs performing allogeneic and autologous hematopoietic cell transplantation (HCT) and cellular therapy such as with CAR T cells. Risk factors for severe disease include age and predisposing conditions such as cancer. The true impact on stem cell transplant and CAR T-cell recipients in unknown. The European Society for Blood and Marrow Transplantation (EBMT) has therefore developed recommendations for transplant programs and physicians caring for these patients. These guidelines were developed by experts from the Infectious Diseases Working Party and have been endorsed by EBMT's scientific council and board. This work intends to provide guidelines for transplant centers, management of transplant candidates and recipients, and donor issues until the COVID-19 pandemic has passed.", "doi": "10.1038/s41409-020-0919-0", "pmid": "32404975", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41409-020-0919-0"}, {"db": "pmc", "key": "PMC7220575"}], "notes": [], "created": "2020-11-26T12:17:04.466Z", "modified": "2020-12-10T08:45:08.633Z"}, {"entity": "publication", "iuid": "52852cdfbb244df3b213b74fd505f389", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/52852cdfbb244df3b213b74fd505f389.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/52852cdfbb244df3b213b74fd505f389"}}, "title": "The Potential of Low Molecular Weight Heparin to Mitigate Cytokine Storm in Severe COVID-19 Patients: A Retrospective Cohort Study.", "authors": [{"family": "Shi", "given": "Chen", "initials": "C"}, {"family": "Wang", "given": "Cong", "initials": "C"}, {"family": "Wang", "given": "Hanxiang", "initials": "H"}, {"family": "Yang", "given": "Chao", "initials": "C"}, {"family": "Cai", "given": "Fei", "initials": "F"}, {"family": "Zeng", "given": "Fang", "initials": "F"}, {"family": "Cheng", "given": "Fang", "initials": "F"}, {"family": "Liu", "given": "Yihui", "initials": "Y"}, {"family": "Zhou", "given": "Taotao", "initials": "T"}, {"family": "Deng", "given": "Bin", "initials": "B"}, {"family": "Vlodavsky", "given": "Israel", "initials": "I"}, {"family": "Li", "given": "Jin-Ping", "initials": "JP"}, {"family": "Zhang", "given": "Yu", "initials": "Y"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Clin Transl Sci", "issn": "1752-8062", "issn-l": "1752-8054", "volume": "13", "issue": "6", "pages": "1087-1095"}, "abstract": "On March 11, 2020, the World Health Organization declared its assessment of coronavirus disease 2019 (COVID-19) as a global pandemic. However, specific anti-severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) drugs are still under development, and patients are managed by multiple complementary treatments. We performed a retrospective analysis to compare and evaluate the effect of low molecular weight heparin (LMWH) treatment on disease progression. For this purpose, the clinical records and laboratory indicators were extracted from electronic medical records of 42 patients with COVID-19 (21 of whom were treated with LMWH, and 21 without LMWH) hospitalized (Union Hospital of Huazhong University of Science and Technology) from February 1 to March 15, 2020. Changes in the percentage of lymphocytes before and after LMWH treatment were significantly different from those in the control group (P = 0.011). Likewise, changes in the levels of D-dimer and fibrinogen degradation products in the LMWH group before and after treatment were significantly different from those in the control group (P = 0.035). Remarkably, IL-6 levels were significantly reduced after LMWH treatment (P = 0.006), indicating that, besides other beneficial properties, LMWH may exert an anti-inflammatory effect and attenuate in part the \"cytokine storm\" induced by the virus. Our results support the use of LMWH as a potential therapeutic drug for the treatment of COVID-19, paving the way for a subsequent well-controlled clinical study.", "doi": "10.1111/cts.12880", "pmid": "32881340", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7719364"}], "notes": [], "created": "2020-11-22T09:54:40.820Z", "modified": "2023-06-19T15:37:44.972Z"}, {"entity": "publication", "iuid": "30c03419298947d887addc0c0ff7cb9b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/30c03419298947d887addc0c0ff7cb9b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/30c03419298947d887addc0c0ff7cb9b"}}, "title": "Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future.", "authors": [{"family": "Mok", "given": "Vincent C T", "initials": "VCT"}, {"family": "Pendlebury", "given": "Sarah", "initials": "S"}, {"family": "Wong", "given": "Adrian", "initials": "A"}, {"family": "Alladi", "given": "Suvarna", "initials": "S"}, {"family": "Au", "given": "Lisa", "initials": "L"}, {"family": "Bath", "given": "Philip M", "initials": "PM"}, {"family": "Biessels", "given": "Geert Jan", "initials": "GJ"}, {"family": "Chen", "given": "Christopher", "initials": "C"}, {"family": "Cordonnier", "given": "Charlotte", "initials": "C"}, {"family": "Dichgans", "given": "Martin", "initials": "M"}, {"family": "Dominguez", "given": "Jacqueline", "initials": "J"}, {"family": "Gorelick", "given": "Philip B", "initials": "PB"}, {"family": "Kim", "given": "SangYun", "initials": "S"}, {"family": "Kwok", "given": "Timothy", "initials": "T"}, {"family": "Greenberg", "given": "Steven M", "initials": "SM"}, {"family": "Jia", "given": "Jianping", "initials": "J"}, {"family": "Kalaria", "given": "Rajesh", "initials": "R"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Naegandran", "given": "Kandiah", "initials": "K"}, {"family": "Lam", "given": "Linda C W", "initials": "LCW"}, {"family": "Lam", "given": "Bonnie Yin Ka", "initials": "BYK"}, {"family": "Lee", "given": "Allen T C", "initials": "ATC"}, {"family": "Markus", "given": "Hugh S", "initials": "HS"}, {"family": "O'Brien", "given": "John", "initials": "J"}, {"family": "Pai", "given": "Ming-Chyi", "initials": "MC"}, {"family": "Pantoni", "given": "Leonardo", "initials": "L"}, {"family": "Sachdev", "given": "Perminder", "initials": "P"}, {"family": "Skoog", "given": "Ingmar", "initials": "I"}, {"family": "Smith", "given": "Eric E", "initials": "EE"}, {"family": "Srikanth", "given": "Velandai", "initials": "V"}, {"family": "Suh", "given": "Guk-Hee", "initials": "GH"}, {"family": "Wardlaw", "given": "Joanna", "initials": "J"}, {"family": "Ko", "given": "Ho", "initials": "H"}, {"family": "Black", "given": "Sandra E", "initials": "SE"}, {"family": "Scheltens", "given": "Philip", "initials": "P"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Alzheimers Dement", "issn": "1552-5279", "volume": "16", "issue": "11", "pages": "1571-1581", "issn-l": "1552-5260"}, "abstract": "We have provided an overview on the profound impact of COVID-19 upon older people with Alzheimer's disease and other dementias and the challenges encountered in our management of dementia in different health-care settings, including hospital, out-patient, care homes, and the community during the COVID-19 pandemic. We have also proposed a conceptual framework and practical suggestions for health-care providers in tackling these challenges, which can also apply to the care of older people in general, with or without other neurological diseases, such as stroke or parkinsonism. We believe this review will provide strategic directions and set standards for health-care leaders in dementia, including governmental bodies around the world in coordinating emergency response plans for protecting and caring for older people with dementia amid the COIVD-19 outbreak, which is likely to continue at varying severity in different regions around the world in the medium term.", "doi": "10.1002/alz.12143", "pmid": "32789951", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7436526"}], "notes": [], "created": "2020-11-26T12:18:00.247Z", "modified": "2020-11-30T08:41:01.767Z"}, {"entity": "publication", "iuid": "9a77c42026f74ace999a6c8baae5ed4a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9a77c42026f74ace999a6c8baae5ed4a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9a77c42026f74ace999a6c8baae5ed4a"}}, "title": "Sports balls as potential SARS-CoV-2 transmission vectors.", "authors": [{"family": "Pelisser", "given": "Michel", "initials": "M"}, {"family": "Thompson", "given": "Joe", "initials": "J"}, {"family": "Majra", "given": "Dasha", "initials": "D"}, {"family": "Youhanna", "given": "Sonia", "initials": "S"}, {"family": "Stebbing", "given": "Justin", "initials": "J"}, {"family": "Davies", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Public Health Pract (Oxf)", "issn": "2666-5352", "volume": "1", "pages": "100029", "issn-l": null}, "abstract": "Objects passed from one player to another have not been assessed for their ability to transmit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We found that the surface of sport balls, notably a football, tennis ball, golf ball, and cricket ball could not harbour inactivated virus when it was swabbed onto the surface, even for 30 \u200bs. However, when high concentrations of 5000 \u200bdC/mL and 10,000 \u200bdC/mL are directly pipetted onto the balls, it could be detected after for short time periods. Sports objects can only harbour inactivated SARS-CoV-2 under specific, directly transferred conditions, but wiping with a dry tissue or moist 'baby wipe' or dropping and rolling the balls removes all detectable viral traces. This has helpful implications to sporting events.", "doi": "10.1016/j.puhip.2020.100029", "pmid": "34173569", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S2666-5352(20)30028-8"}, {"db": "pmc", "key": "PMC7350886"}], "notes": [], "created": "2021-06-28T18:09:36.233Z", "modified": "2021-08-23T14:39:57.598Z"}, {"entity": "publication", "iuid": "a107d4a9a1434c93ba1cbee8a5c6ca16", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a107d4a9a1434c93ba1cbee8a5c6ca16.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a107d4a9a1434c93ba1cbee8a5c6ca16"}}, "title": "Risks to healthcare workers following tracheal intubation of patients with COVID-19: a prospective international multicentre cohort study.", "authors": [{"family": "El-Boghdadly", "given": "K", "initials": "K"}, {"family": "Wong", "given": "D J N", "initials": "DJN"}, {"family": "Owen", "given": "R", "initials": "R"}, {"family": "Neuman", "given": "M D", "initials": "MD"}, {"family": "Pocock", "given": "S", "initials": "S"}, {"family": "Carlisle", "given": "J B", "initials": "JB"}, {"family": "Johnstone", "given": "C", "initials": "C"}, {"family": "Andruszkiewicz", "given": "P", "initials": "P"}, {"family": "Baker", "given": "P A", "initials": "PA"}, {"family": "Biccard", "given": "B M", "initials": "BM"}, {"family": "Bryson", "given": "G L", "initials": "GL"}, {"family": "Chan", "given": "M T V", "initials": "MTV"}, {"family": "Cheng", "given": "M H", "initials": "MH"}, {"family": "Chin", "given": "K J", "initials": "KJ"}, {"family": "Coburn", "given": "M", "initials": "M"}, {"family": "Jonsson Fagerlund", "given": "M", "initials": "M"}, {"family": "Myatra", "given": "S N", "initials": "SN"}, {"family": "Myles", "given": "P S", "initials": "PS"}, {"family": "O'Sullivan", "given": "E", "initials": "E"}, {"family": "Pasin", "given": "L", "initials": "L"}, {"family": "Shamim", "given": "F", "initials": "F"}, {"family": "van Klei", "given": "W A", "initials": "WA"}, {"family": "Ahmad", "given": "I", "initials": "I"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Anaesthesia", "issn": "1365-2044", "issn-l": "0003-2409", "volume": "75", "issue": "11", "pages": "1437-1447"}, "abstract": "Healthcare workers involved in aerosol-generating procedures, such as tracheal intubation, may be at elevated risk of acquiring COVID-19. However, the magnitude of this risk is unknown. We conducted a prospective international multicentre cohort study recruiting healthcare workers participating in tracheal intubation of patients with suspected or confirmed COVID-19. Information on tracheal intubation episodes, personal protective equipment use and subsequent provider health status was collected via self-reporting. The primary endpoint was the incidence of laboratory-confirmed COVID-19 diagnosis or new symptoms requiring self-isolation or hospitalisation after a tracheal intubation episode. Cox regression analysis examined associations between the primary endpoint and healthcare worker characteristics, procedure-related factors and personal protective equipment use. Between 23 March and 2 June 2020, 1718 healthcare workers from 503 hospitals in 17 countries reported 5148 tracheal intubation episodes. The overall incidence of the primary endpoint was 10.7% over a median (IQR [range]) follow-up of 32 (18-48 [0-116]) days. The cumulative incidence within 7, 14 and 21 days of the first tracheal intubation episode was 3.6%, 6.1% and 8.5%, respectively. The risk of the primary endpoint varied by country and was higher in women, but was not associated with other factors. Around 1 in 10 healthcare workers involved in tracheal intubation of patients with suspected or confirmed COVID-19 subsequently reported a COVID-19 outcome. This has human resource implications for institutional capacity to deliver essential healthcare services, and wider societal implications for COVID-19 transmission.", "doi": "10.1111/anae.15170", "pmid": "32516833", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7300828"}], "notes": [], "created": "2020-11-25T09:57:47.346Z", "modified": "2022-11-09T08:32:15.026Z"}, {"entity": "publication", "iuid": "9b49421a30994ffc84789e00e0c9f02d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b49421a30994ffc84789e00e0c9f02d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b49421a30994ffc84789e00e0c9f02d"}}, "title": "Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis: a multinational, retrospective study.", "authors": [{"family": "Lane", "given": "Jennifer C E", "initials": "JCE"}, {"family": "Weaver", "given": "James", "initials": "J"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "Abrahao", "given": "Maria Tereza F", "initials": "MTF"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Biedermann", "given": "Patricia", "initials": "P"}, {"family": "Banda", "given": "Juan M", "initials": "JM"}, {"family": "Burn", "given": "Edward", "initials": "E"}, {"family": "Casajust", "given": "Paula", "initials": "P"}, {"family": "Conover", "given": "Mitchell M", "initials": "MM"}, {"family": "Culhane", "given": "Aedin C", "initials": "AC"}, {"family": "Davydov", "given": "Alexander", "initials": "A"}, {"family": "DuVall", "given": "Scott L", "initials": "SL"}, {"family": "Dymshyts", "given": "Dmitry", "initials": "D"}, {"family": "Fernandez-Bertolin", "given": "Sergio", "initials": "S"}, {"family": "Fi\u0161ter", "given": "Kristina", "initials": "K"}, {"family": "Hardin", "given": "Jill", "initials": "J"}, {"family": "Hester", "given": "Laura", "initials": "L"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Kaas-Hansen", "given": "Benjamin Skov", "initials": "BS"}, {"family": "Kent", "given": "Seamus", "initials": "S"}, {"family": "Khosla", "given": "Sajan", "initials": "S"}, {"family": "Kolovos", "given": "Spyros", "initials": "S"}, {"family": "Lambert", "given": "Christophe G", "initials": "CG"}, {"family": "van der Lei", "given": "Johan", "initials": "J"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Makadia", "given": "Rupa", "initials": "R"}, {"family": "Margulis", "given": "Andrea V", "initials": "AV"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Mehta", "given": "Paras", "initials": "P"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Morgan-Stewart", "given": "Henry", "initials": "H"}, {"family": "Mosseveld", "given": "Mees", "initials": "M"}, {"family": "Newby", "given": "Danielle", "initials": "D"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Park", "given": "Rae Woong", "initials": "RW"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A"}, {"family": "Rao", "given": "Gowtham A", "initials": "GA"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Reps", "given": "Jenna", "initials": "J"}, {"family": "Rijnbeek", "given": "Peter", "initials": "P"}, {"family": "Sathappan", "given": "Selva Muthu Kumaran", "initials": "SMK"}, {"family": "Schuemie", "given": "Martijn", "initials": "M"}, {"family": "Seager", "given": "Sarah", "initials": "S"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Shoaibi", "given": "Azza", "initials": "A"}, {"family": "Spotnitz", "given": "Matthew", "initials": "M"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Torre", "given": "Carmen O", "initials": "CO"}, {"family": "Vizcaya", "given": "David", "initials": "D"}, {"family": "Wen", "given": "Haini", "initials": "H"}, {"family": "de Wilde", "given": "Marcel", "initials": "M"}, {"family": "Xie", "given": "Junqing", "initials": "J"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhuk", "given": "Oleg", "initials": "O"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "OHDSI-COVID-19 consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Lancet Rheumatol", "issn": "2665-9913", "volume": "2", "issue": "11", "pages": "e698-e711", "issn-l": null}, "abstract": "Hydroxychloroquine, a drug commonly used in the treatment of rheumatoid arthritis, has received much negative publicity for adverse events associated with its authorisation for emergency use to treat patients with COVID-19 pneumonia. We studied the safety of hydroxychloroquine, alone and in combination with azithromycin, to determine the risk associated with its use in routine care in patients with rheumatoid arthritis.\n\nIn this multinational, retrospective study, new user cohort studies in patients with rheumatoid arthritis aged 18 years or older and initiating hydroxychloroquine were compared with those initiating sulfasalazine and followed up over 30 days, with 16 severe adverse events studied. Self-controlled case series were done to further establish safety in wider populations, and included all users of hydroxychloroquine regardless of rheumatoid arthritis status or indication. Separately, severe adverse events associated with hydroxychloroquine plus azithromycin (compared with hydroxychloroquine plus amoxicillin) were studied. Data comprised 14 sources of claims data or electronic medical records from Germany, Japan, the Netherlands, Spain, the UK, and the USA. Propensity score stratification and calibration using negative control outcomes were used to address confounding. Cox models were fitted to estimate calibrated hazard ratios (HRs) according to drug use. Estimates were pooled where the I2 value was less than 0\u00b74.\n\nThe study included 956 374 users of hydroxychloroquine, 310 350 users of sulfasalazine, 323 122 users of hydroxychloroquine plus azithromycin, and 351 956 users of hydroxychloroquine plus amoxicillin. No excess risk of severe adverse events was identified when 30-day hydroxychloroquine and sulfasalazine use were compared. Self-controlled case series confirmed these findings. However, long-term use of hydroxychloroquine appeared to be associated with increased cardiovascular mortality (calibrated HR 1\u00b765 [95% CI 1\u00b712-2\u00b744]). Addition of azithromycin appeared to be associated with an increased risk of 30-day cardiovascular mortality (calibrated HR 2\u00b719 [95% CI 1\u00b722-3\u00b795]), chest pain or angina (1\u00b715 [1\u00b705-1\u00b726]), and heart failure (1\u00b722 [1\u00b702-1\u00b745]).\n\nHydroxychloroquine treatment appears to have no increased risk in the short term among patients with rheumatoid arthritis, but in the long term it appears to be associated with excess cardiovascular mortality. The addition of azithromycin increases the risk of heart failure and cardiovascular mortality even in the short term. We call for careful consideration of the benefit-risk trade-off when counselling those on hydroxychloroquine treatment.\n\nNational Institute for Health Research (NIHR) Oxford Biomedical Research Centre, NIHR Senior Research Fellowship programme, US National Institutes of Health, US Department of Veterans Affairs, Janssen Research and Development, IQVIA, Korea Health Industry Development Institute through the Ministry of Health and Welfare Republic of Korea, Versus Arthritis, UK Medical Research Council Doctoral Training Partnership, Foundation Alfonso Martin Escudero, Innovation Fund Denmark, Novo Nordisk Foundation, Singapore Ministry of Health's National Medical Research Council Open Fund Large Collaborative Grant, VINCI, Innovative Medicines Initiative 2 Joint Undertaking, EU's Horizon 2020 research and innovation programme, and European Federation of Pharmaceutical Industries and Associations.", "doi": "10.1016/S2665-9913(20)30276-9", "pmid": "32864627", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "http://evidence.ohdsi.org:3838/Covid19EstimationHydroxychloroquine/", "description": "Data aggregated by data source"}], "notes": [], "created": "2020-12-07T10:13:23.488Z", "modified": "2021-02-26T08:45:48.505Z"}, {"entity": "publication", "iuid": "ac2573f14bbc4fd98be9ce7ae7202b55", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac2573f14bbc4fd98be9ce7ae7202b55.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac2573f14bbc4fd98be9ce7ae7202b55"}}, "title": "Residential context and COVID-19 mortality among adults aged 70 years and older in Stockholm: a population-based, observational study using individual-level data.", "authors": [{"family": "Brand\u00e9n", "given": "Maria", "initials": "M"}, {"family": "Aradhya", "given": "Siddartha", "initials": "S"}, {"family": "Kolk", "given": "Martin", "initials": "M"}, {"family": "H\u00e4rk\u00f6nen", "given": "Juho", "initials": "J"}, {"family": "Drefahl", "given": "Sven", "initials": "S"}, {"family": "Malmberg", "given": "Bo", "initials": "B"}, {"family": "Rostila", "given": "Mikael", "initials": "M"}, {"family": "Cederstr\u00f6m", "given": "Agneta", "initials": "A"}, {"family": "Andersson", "given": "Gunnar", "initials": "G"}, {"family": "Mussino", "given": "Eleonora", "initials": "E"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Lancet Healthy Longev", "issn": "2666-7568", "volume": "1", "issue": "2", "pages": "e80-e88", "issn-l": null}, "abstract": "Housing characteristics and neighbourhood context are considered risk factors for COVID-19 mortality among older adults. The aim of this study was to investigate how individual-level housing and neighbourhood characteristics are associated with COVID-19 mortality in older adults.\n\nFor this population-based, observational study, we used data from the cause-of-death register held by the Swedish National Board of Health and Welfare to identify recorded COVID-19 mortality and mortality from other causes among individuals (aged \u226570 years) in Stockholm county, Sweden, between March 12 and May 8, 2020. This information was linked to population-register data from December, 2019, including socioeconomic, demographic, and residential characteristics. We ran Cox proportional hazards regressions for the risk of dying from COVID-19 and from all other causes. The independent variables were area (m 2) per individual in the household, the age structure of the household, type of housing, confirmed cases of COVID-19 in the borough, and neighbourhood population density. All models were adjusted for individual age, sex, country of birth, income, and education.\n\nOf 279 961 individuals identified to be aged 70 years or older on March 12, 2020, and residing in Stockholm in December, 2019, 274 712 met the eligibility criteria and were included in the study population. Between March 12 and May 8, 2020, 3386 deaths occurred, of which 1301 were reported as COVID-19 deaths. In fully adjusted models, household and neighbourhood characteristics were independently associated with COVID-19 mortality among older adults. Compared with living in a household with individuals aged 66 years or older, living with someone of working age (<66 years) was associated with increased COVID-19 mortality (hazard ratio 1\u00b76; 95% CI 1\u00b73-2\u00b70). Living in a care home was associated with an increased risk of COVID-19 mortality (4\u00b71; 3\u00b75-4\u00b79) compared with living in independent housing. Living in neighbourhoods with the highest population density (\u22655000 individuals per km 2) was associated with higher COVID-19 mortality (1\u00b77; 1\u00b71-2\u00b74) compared with living in the least densely populated neighbourhoods (0 to <150 individuals per km2).\n\nClose exposure to working-age household members and neighbours is associated with increased COVID-19 mortality among older adults. Similarly, living in a care home is associated with increased mortality, potentially through exposure to visitors and care workers, but also due to poor underlying health among care-home residents. These factors should be considered when developing strategies to protect this group.\n\nSwedish Research Council for Health, Working Life and Welfare (FORTE), Swedish Foundation for Humanities and Social Sciences.", "doi": "10.1016/S2666-7568(20)30016-7", "pmid": "33521770", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-7568(20)30016-7"}, {"db": "pmc", "key": "PMC7832817"}], "notes": [], "created": "2021-02-04T18:25:32.385Z", "modified": "2021-02-26T08:45:48.566Z"}, {"entity": "publication", "iuid": "8d3b6bf4b6704177a969022eb0453cca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8d3b6bf4b6704177a969022eb0453cca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8d3b6bf4b6704177a969022eb0453cca"}}, "title": "Pre-pandemic psychiatric disorders and risk of COVID-19: a UK Biobank cohort analysis.", "authors": [{"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Chen", "given": "Wenwen", "initials": "W"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Chen", "given": "Yilong", "initials": "Y"}, {"family": "Zeng", "given": "Yu", "initials": "Y"}, {"family": "Sun", "given": "Yajing", "initials": "Y"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "He", "given": "Junhui", "initials": "J"}, {"family": "Qu", "given": "Yuanyuan", "initials": "Y"}, {"family": "Lu", "given": "Donghao", "initials": "D"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Lancet Healthy Longev", "issn": "2666-7568", "volume": "1", "issue": "2", "pages": "e69-e79", "issn-l": null}, "abstract": "Psychiatric morbidities have been associated with a risk of severe infections through compromised immunity, health behaviours, or both. However, data are scarce on the association between multiple types of pre-pandemic psychiatric disorders and COVID-19. We aimed to assess the association between pre-pandemic psychiatric disorders and the subsequent risk of COVID-19 using UK Biobank.\n\nFor this cohort analysis, we included participants from UK Biobank who were registered in England and excluded individuals who died before Jan 31, 2020, (the start of the COVID-19 outbreak in the UK) or had withdrawn from UK Biobank. Participants diagnosed with a psychiatric disorder before Jan 31 were included in the group of individuals with pre-pandemic psychiatric disorders, whereas participants without a diagnosis before the outbreak were included in the group of individuals without pre-pandemic psychiatric disorders. We used the Public Health England dataset, UK Biobank hospital data, and death registers to collect data on COVID-19 cases. To examine the relationship between pre-pandemic psychiatric disorders and susceptibility to COVID-19, we used logistic regression models to estimate odds ratios (ORs), controlling for multiple confounders and somatic comorbidities. Key outcomes were all COVID-19, COVID-19 specifically diagnosed in inpatient care, and COVID-19-related deaths. ORs were also estimated separately for each psychiatric disorder and on the basis of the number of pre-pandemic psychiatric disorders. As a positive disease control, we repeated analyses for hospitalisation for other infections.\n\nWe included 421 014 UK Biobank participants in our study and assessed their COVID-19 status between Jan 31 and July 26, 2020. 50 809 participants were diagnosed with psychiatric disorders before the outbreak, while 370 205 participants had no psychiatric disorders. The mean age at outbreak was 67\u00b780 years (SD 8\u00b712). We observed an elevated risk of COVID-19 among individuals with pre-pandemic psychiatric disorders compared with that of individuals without such conditions. The fully adjusted ORs were 1\u00b744 (95% CI 1\u00b728-1\u00b762) for All COVID-19 cases, 1\u00b755 (1\u00b734-1\u00b778) for Inpatient COVID-19 cases, and 2\u00b703 (1\u00b759-2\u00b759) for COVID-19-related deaths. We observed excess risk, defined as risk that increased with the number of pre-pandemic psychiatric disorders, across all diagnostic categories of pre-pandemic psychiatric disorders. We also observed an association between psychiatric disorders and elevated risk of hospitalisation due to other infections (OR 1\u00b774, 95% CI 1\u00b758-1\u00b793).\n\nOur findings suggest that pre-existing psychiatric disorders are associated with an increased risk of COVID-19. These findings underscore the need for surveillance of and care for populations with pre-existing psychiatric disorders during the COVID-19 pandemic.\n\nNational Natural Science Foundation of China.", "doi": "10.1016/S2666-7568(20)30013-1", "pmid": "33521769", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2666-7568(20)30013-1"}, {"db": "pmc", "key": "PMC7832159"}], "notes": [], "created": "2021-02-04T18:27:04.421Z", "modified": "2021-02-26T08:47:00.051Z"}, {"entity": "publication", "iuid": "e2e4e3fe83c74ab3b2dee97372c04bb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2e4e3fe83c74ab3b2dee97372c04bb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2e4e3fe83c74ab3b2dee97372c04bb1"}}, "title": "Perspectives from CO+RE: How COVID-19 changed our food systems and food security paradigms.", "authors": [{"family": "Bakalis", "given": "Serafim", "initials": "S"}, {"family": "Valdramidis", "given": "Vasilis P", "initials": "VP"}, {"family": "Argyropoulos", "given": "Dimitrios", "initials": "D"}, {"family": "Ahrne", "given": "Lilia", "initials": "L"}, {"family": "Chen", "given": "Jianshe", "initials": "J"}, {"family": "Cullen", "given": "P J", "initials": "PJ"}, {"family": "Cummins", "given": "Enda", "initials": "E"}, {"family": "Datta", "given": "Ashim K", "initials": "AK"}, {"family": "Emmanouilidis", "given": "Christos", "initials": "C"}, {"family": "Foster", "given": "Tim", "initials": "T"}, {"family": "Fryer", "given": "Peter J", "initials": "PJ"}, {"family": "Gouseti", "given": "Ourania", "initials": "O"}, {"family": "Hospido", "given": "Almudena", "initials": "A"}, {"family": "Knoerzer", "given": "Kai", "initials": "K"}, {"family": "LeBail", "given": "Alain", "initials": "A"}, {"family": "Marangoni", "given": "Alejandro G", "initials": "AG"}, {"family": "Rao", "given": "Pingfan", "initials": "P"}, {"family": "Schl\u00fcter", "given": "Oliver K", "initials": "OK"}, {"family": "Taoukis", "given": "Petros", "initials": "P"}, {"family": "Xanthakis", "given": "Epameinondas", "initials": "E"}, {"family": "Van Impe", "given": "Jan F M", "initials": "JFM"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Curr Res Food Sci", "issn": "2665-9271", "issn-l": null, "volume": "3", "issue": null, "pages": "166-172"}, "abstract": "Perspective", "doi": "10.1016/j.crfs.2020.05.003", "pmid": "32908972", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2665-9271(20)30024-1"}, {"db": "pmc", "key": "PMC7265867"}], "notes": [], "created": "2020-12-03T15:52:32.403Z", "modified": "2020-12-03T15:53:22.094Z"}, {"entity": "publication", "iuid": "d3b317fa2c674197819672c405ab928b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3b317fa2c674197819672c405ab928b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3b317fa2c674197819672c405ab928b"}}, "title": "Periodontal disease and targeted prevention using aMMP-8 point-of-care oral fluid analytics in the COVID-19 era.", "authors": [{"family": "R\u00e4is\u00e4nen", "given": "Ismo T", "initials": "IT"}, {"family": "Umeizudike", "given": "Kehinde A", "initials": "KA"}, {"family": "P\u00e4rn\u00e4nen", "given": "Pirjo", "initials": "P"}, {"family": "Heikkil\u00e4", "given": "Pia", "initials": "P"}, {"family": "Tervahartiala", "given": "Taina", "initials": "T"}, {"family": "Nwhator", "given": "Solomon O", "initials": "SO"}, {"family": "Grigoriadis", "given": "Andreas", "initials": "A"}, {"family": "Sakellari", "given": "Dimitra", "initials": "D"}, {"family": "Sorsa", "given": "Timo", "initials": "T"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Med Hypotheses", "issn": "1532-2777", "volume": "144", "issue": null, "pages": "110276", "issn-l": null}, "abstract": "Periodontal disease is a chronic multifactorial infectious and inflammatory disease associated with several chronic systemic diseases, such as diabetes, cardiovascular diseases (CVD), chronic obstructive pulmonary disease, hypertension, Alzheimer's disease and so on. These same systemic diseases have been associated with severe COVID-19 infections. Several recent studies have suggested hypotheses for the potential association between periodontal disease and severe COVID-19. Periodontal disease is also one of the most prevalent diseases globally. All this supports the importance of good oral health, also in the COVID-19 era. Thus, new strategies and approaches to identify patients at risk of periodontal disease could be beneficial to enhance secondary prevention, especially if targeted to COVID-19 risk groups. Diagnostic biomarkers for periodontal disease have been researched extensively. Potential biomarkers in oral fluid with currently available rapid non-invasive point-of-care technology, such as aMMP-8, could help to extend screening and identification of patients at risk for periodontal disease also to situations and places where professional dental expertise and equipment are limited or unavailable. i.e., nursing and care homes, and rural and distant places. The oral fluid point-of-care technologies could also be useful in the hands of medical professionals (diabetes, CVD, etc.) to identify patients at risk for undiagnosed periodontal disease and to refer them to a dentist for examination and evaluation. Finally, if there is a causality between periodontal disease and severe COVID-19 infections, these point-of-care oral fluid biomarker technologies could possibly also help in the assessment of the risk of deterioration and complications.", "doi": "10.1016/j.mehy.2020.110276", "pmid": "33254580", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0306-9877(20)32157-5"}], "notes": [], "created": "2020-12-03T08:21:29.104Z", "modified": "2021-02-26T08:45:48.749Z"}, {"entity": "publication", "iuid": "2c69f0d6d0894d9ba02912d78ac4d7c0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2c69f0d6d0894d9ba02912d78ac4d7c0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2c69f0d6d0894d9ba02912d78ac4d7c0"}}, "title": "Partisan differences in physical distancing are linked to health outcomes during the COVID-19 pandemic.", "authors": [{"family": "Gollwitzer", "given": "Anton", "initials": "A"}, {"family": "Martel", "given": "Cameron", "initials": "C"}, {"family": "Brady", "given": "William J", "initials": "WJ"}, {"family": "P\u00e4rnamets", "given": "Philip", "initials": "P"}, {"family": "Freedman", "given": "Isaac G", "initials": "IG"}, {"family": "Knowles", "given": "Eric D", "initials": "ED"}, {"family": "Van Bavel", "given": "Jay J", "initials": "JJ"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Nat Hum Behav", "issn": "2397-3374", "issn-l": "2397-3374", "volume": "4", "issue": "11", "pages": "1186-1197"}, "abstract": "Numerous polls suggest that COVID-19 is a profoundly partisan issue in the United States. Using the geotracking data of 15 million smartphones per day, we found that US counties that voted for Donald Trump (Republican) over Hillary Clinton (Democrat) in the 2016 presidential election exhibited 14% less physical distancing between March and May 2020. Partisanship was more strongly associated with physical distancing than numerous other factors, including counties' COVID-19 cases, population density, median income, and racial and age demographics. Contrary to our predictions, the observed partisan gap strengthened over time and remained when stay-at-home orders were active. Additionally, county-level consumption of conservative media (Fox News) was related to reduced physical distancing. Finally, the observed partisan differences in distancing were associated with subsequently higher COVID-19 infection and fatality growth rates in pro-Trump counties. Taken together, these data suggest that US citizens' responses to COVID-19 are subject to a deep-and consequential-partisan divide.", "doi": "10.1038/s41562-020-00977-7", "pmid": "33139897", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41562-020-00977-7"}], "notes": [], "created": "2020-11-27T10:14:47.352Z", "modified": "2022-11-09T08:32:46.853Z"}, {"entity": "publication", "iuid": "99a5591d953744048ca94c23f5b35e2a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/99a5591d953744048ca94c23f5b35e2a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/99a5591d953744048ca94c23f5b35e2a"}}, "title": "Outcomes following SARS-CoV-2 infection in liver transplant recipients: an international registry study.", "authors": [{"family": "Webb", "given": "Gwilym J", "initials": "GJ"}, {"family": "Marjot", "given": "Thomas", "initials": "T"}, {"family": "Cook", "given": "Jonathan A", "initials": "JA"}, {"family": "Aloman", "given": "Costica", "initials": "C"}, {"family": "Armstrong", "given": "Matthew J", "initials": "MJ"}, {"family": "Brenner", "given": "Erica J", "initials": "EJ"}, {"family": "Catana", "given": "Maria-Andreea", "initials": "MA"}, {"family": "Cargill", "given": "Tamsin", "initials": "T"}, {"family": "Dhanasekaran", "given": "Renumathy", "initials": "R"}, {"family": "Garc\u00eda-Ju\u00e1rez", "given": "Ignacio", "initials": "I"}, {"family": "Hagstr\u00f6m", "given": "Hannes", "initials": "H"}, {"family": "Kennedy", "given": "James M", "initials": "JM"}, {"family": "Marshall", "given": "Aileen", "initials": "A"}, {"family": "Masson", "given": "Steven", "initials": "S"}, {"family": "Mercer", "given": "Carolyn J", "initials": "CJ"}, {"family": "Perumalswami", "given": "Ponni V", "initials": "PV"}, {"family": "Ruiz", "given": "Isaac", "initials": "I"}, {"family": "Thaker", "given": "Sarang", "initials": "S"}, {"family": "Ufere", "given": "Nneka N", "initials": "NN"}, {"family": "Barnes", "given": "Eleanor", "initials": "E"}, {"family": "Barritt", "given": "Alfred S", "initials": "AS"}, {"family": "Moon", "given": "Andrew M", "initials": "AM"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Lancet Gastroenterol Hepatol", "issn": "2468-1253", "volume": "5", "issue": "11", "pages": "1008-1016", "issn-l": null}, "abstract": "Despite concerns that patients with liver transplants might be at increased risk of adverse outcomes from COVID-19 because of coexisting comorbidities and use of immunosuppressants, the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on this patient group remains unclear. We aimed to assess the clinical outcomes in these patients.\n\nIn this multicentre cohort study, we collected data on patients with laboratory-confirmed SARS-CoV-2 infection, who were older than 18 years, who had previously received a liver transplant, and for whom data had been submitted by clinicians to one of two international registries (COVID-Hep and SECURE-Cirrhosis) at the end of the patient's disease course. Patients without a known hospitalisation status or mortality outcome were excluded. For comparison, data from a contemporaneous cohort of consecutive patients with SARS-CoV-2 infection who had not received a liver transplant were collected from the electronic patient records of the Oxford University Hospitals National Health Service Foundation Trust. We compared the cohorts with regard to several outcomes (including death, hospitalisation, intensive care unit [ICU] admission, requirement for intensive care, and need for invasive ventilation). A propensity score-matched analysis was done to test for an association between liver transplant and death.\n\nBetween March 25 and June 26, 2020, data were collected for 151 adult liver transplant recipients from 18 countries (median age 60 years [IQR 47-66], 102 [68%] men, 49 [32%] women) and 627 patients who had not undergone liver transplantation (median age 73 years [44-84], 329 [52%] men, 298 [48%] women). The groups did not differ with regard to the proportion of patients hospitalised (124 [82%] patients in the liver transplant cohort vs 474 [76%] in the comparison cohort, p=0\u00b7106), or who required intensive care (47 [31%] vs 185 [30%], p=0\u00b7837). However, ICU admission (43 [28%] vs 52 [8%], p<0\u00b70001) and invasive ventilation (30 [20%] vs 32 [5%], p<0\u00b70001) were more frequent in the liver transplant cohort. 28 (19%) patients in the liver transplant cohort died, compared with 167 (27%) in the comparison cohort (p=0\u00b7046). In the propensity score-matched analysis (adjusting for age, sex, creatinine concentration, obesity, hypertension, diabetes, and ethnicity), liver transplantation did not significantly increase the risk of death in patients with SARS-CoV-2 infection (absolute risk difference 1\u00b74% [95% CI -7\u00b77 to 10\u00b74]). Multivariable logistic regression analysis showed that age (odds ratio 1\u00b706 [95% CI 1\u00b701 to 1\u00b711] per 1 year increase), serum creatinine concentration (1\u00b757 [1\u00b705 to 2\u00b736] per 1 mg/dL increase), and non-liver cancer (18\u00b730 [1\u00b796 to 170\u00b775]) were associated with death among liver transplant recipients.\n\nLiver transplantation was not independently associated with death, whereas increased age and presence of comorbidities were. Factors other than transplantation should be preferentially considered in relation to physical distancing and provision of medical care for patients with liver transplants during the COVID-19 pandemic.\n\nEuropean Association for the Study of the Liver, US National Institutes of Health, UK National Institute for Health Research.", "doi": "10.1016/S2468-1253(20)30271-5", "pmid": "32866433", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2468-1253(20)30271-5"}, {"db": "pmc", "key": "PMC7455160"}], "notes": [], "created": "2020-12-07T07:52:04.415Z", "modified": "2021-02-26T08:45:48.494Z"}, {"entity": "publication", "iuid": "da1a6cf9002a49bfa808f8b5c9f6ed12", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/da1a6cf9002a49bfa808f8b5c9f6ed12.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/da1a6cf9002a49bfa808f8b5c9f6ed12"}}, "title": "On-demand mobile health infrastructures to allow comprehensive remote atrial fibrillation and risk factor management through teleconsultation.", "authors": [{"family": "Hermans", "given": "Astrid N L", "initials": "ANL"}, {"family": "van der Velden", "given": "Rachel M J", "initials": "RMJ"}, {"family": "Gawalko", "given": "Monika", "initials": "M"}, {"family": "Verhaert", "given": "Dominique V M", "initials": "DVM"}, {"family": "Desteghe", "given": "Lien", "initials": "L"}, {"family": "Duncker", "given": "David", "initials": "D"}, {"family": "Manninger", "given": "Martin", "initials": "M"}, {"family": "Heidbuchel", "given": "Hein", "initials": "H"}, {"family": "Pisters", "given": "Ron", "initials": "R"}, {"family": "Hemels", "given": "Martin", "initials": "M"}, {"family": "Pison", "given": "Laurent", "initials": "L"}, {"family": "Sohaib", "given": "Afzal", "initials": "A"}, {"family": "Sultan", "given": "Arian", "initials": "A"}, {"family": "Steven", "given": "Daniel", "initials": "D"}, {"family": "Wijtvliet", "given": "Petra", "initials": "P"}, {"family": "Tieleman", "given": "Robert", "initials": "R"}, {"family": "Gupta", "given": "Dhiraj", "initials": "D"}, {"family": "Dobrev", "given": "Dobromir", "initials": "D"}, {"family": "Svennberg", "given": "Emma", "initials": "E"}, {"family": "Crijns", "given": "Harry J G M", "initials": "HJGM"}, {"family": "Pluymaekers", "given": "Nikki A H A", "initials": "NAHA"}, {"family": "Hendriks", "given": "Jeroen M", "initials": "JM"}, {"family": "Linz", "given": "Dominik", "initials": "D"}, {"family": "TeleCheck-AF investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Clin Cardiol", "issn": "1932-8737", "volume": "43", "issue": "11", "pages": "1232-1239", "issn-l": "0160-9289"}, "abstract": "Although novel teleconsultation solutions can deliver remote situations that are relatively similar to face-to-face interaction, remote assessment of heart rate and rhythm as well as risk factors remains challenging in patients with atrial fibrillation (AF).\n\nMobile health (mHealth) solutions can support remote AF management.\n\nHerein, we discuss available mHealth tools and strategies on how to incorporate the remote assessment of heart rate, rhythm and risk factors to allow comprehensive AF management through teleconsultation.\n\nParticularly, in the light of the coronavirus disease 2019 (COVID-19) pandemic, there is decreased capacity to see patients in the outpatient clinic and mHealth has become an important component of many AF outpatient clinics. Several validated mHealth solutions are available for remote heart rate and rhythm monitoring as well as for risk factor assessment. mHealth technologies can be used for (semi-)continuous longitudinal monitoring or for short-term on-demand monitoring, dependent on the respective requirements and clinical scenarios. As a possible solution to improve remote AF care through teleconsultation, we introduce the on-demand TeleCheck-AF mHealth approach that allows remote app-based assessment of heart rate and rhythm around teleconsultations, which has been developed and implemented during the COVID-19 pandemic in Europe.\n\nLarge scale international mHealth projects, such as TeleCheck-AF, will provide insight into the additional value and potential limitations of mHealth strategies to remotely manage AF patients. Such mHealth infrastructures may be well suited within an integrated AF-clinic, which may require redesign of practice and reform of health care systems.", "doi": "10.1002/clc.23469", "pmid": "33030259", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7661648"}], "notes": [], "created": "2020-11-26T12:36:00.991Z", "modified": "2020-11-27T12:38:58.997Z"}, {"entity": "publication", "iuid": "f55490e3a83d4d75b26c47c0548597a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f55490e3a83d4d75b26c47c0548597a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f55490e3a83d4d75b26c47c0548597a9"}}, "title": "International registry of otolaryngologist-head and neck surgeons with COVID-19.", "authors": [{"family": "Sowerby", "given": "Leigh J", "initials": "LJ"}, {"family": "Stephenson", "given": "Kate", "initials": "K"}, {"family": "Dickie", "given": "Alexander", "initials": "A"}, {"family": "Lella", "given": "Federico A Di", "initials": "FAD"}, {"family": "Jefferson", "given": "Niall", "initials": "N"}, {"family": "North", "given": "Hannah", "initials": "H"}, {"family": "De Siati", "given": "R Daniele", "initials": "RD"}, {"family": "Maunsell", "given": "Rebecca", "initials": "R"}, {"family": "Herzog", "given": "Michael", "initials": "M"}, {"family": "Nandhan", "given": "Raghu", "initials": "R"}, {"family": "Trozzi", "given": "Marilena", "initials": "M"}, {"family": "Dehgani-Mobaraki", "given": "Puya", "initials": "P"}, {"family": "Melkane", "given": "Antoine", "initials": "A"}, {"family": "Callejas", "given": "Claudio", "initials": "C"}, {"family": "Miljeteig", "given": "Harald", "initials": "H"}, {"family": "Smit", "given": "Diane", "initials": "D"}, {"family": "Reynoso", "given": "Daniel Dibildox", "initials": "DD"}, {"family": "Moura", "given": "Joao Eloi", "initials": "JE"}, {"family": "Hermansson", "given": "Ann", "initials": "A"}, {"family": "Peer", "given": "Shazia", "initials": "S"}, {"family": "Burnell", "given": "Lisa", "initials": "L"}, {"family": "Fakhry", "given": "Nicolas", "initials": "N"}, {"family": "Chiesa-Estomba", "given": "Carlos", "initials": "C"}, {"family": "\u00d6nerci \u00c7elebi", "given": "\u00d6zlem", "initials": "\u00d6"}, {"family": "Karpischenko", "given": "Sergei", "initials": "S"}, {"family": "Sobol", "given": "Steven", "initials": "S"}, {"family": "Sargi", "given": "Zoukaa", "initials": "Z"}, {"family": "Patel", "given": "Zara M", "initials": "ZM"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Int Forum Allergy Rhinol", "issn": "2042-6984", "volume": "10", "issue": "11", "pages": "1201-1208", "issn-l": "2042-6976"}, "abstract": "It has become clear that healthcare workers are at high risk, and otolaryngology has been theorized to be among the highest risk specialties for coronavirus disease 2019 (COVID-19). The purpose of this study was to detail the international impact of COVID-19 among otolaryngologists, and to identify instructional cases.\n\nCountry representatives of the Young Otolaryngologists-International Federation of Otolaryngologic Societies (YO-IFOS) surveyed otolaryngologists through various channels. Nationwide surveys were distributed in 19 countries. The gray literature and social media channels were searched to identify reported deaths of otolaryngologists from COVID-19.\n\nA total of 361 otolaryngologists were identified to have had COVID-19, and data for 325 surgeons was available for analysis. The age range was 25 to 84 years, with one-half under the age of 44 years. There were 24 deaths in the study period, with 83% over age 55 years. Source of infection was likely clinical activity in 175 (54%) cases. Prolonged exposure to a colleague was the source for 37 (11%) surgeons. Six instructional cases were identified where infections occurred during the performance of aerosol-generating operations (tracheostomy, mastoidectomy, epistaxis control, dacryocystorhinostomy, and translabyrinthine resection). In 3 of these cases, multiple operating room attendees were infected, and in 2, the surgeon succumbed to complications of COVID-19.\n\nThe etiology of reported cases within the otolaryngology community appear to stem equally from clinical activity and community spread. Multiple procedures performed by otolaryngologists are aerosol-generating procedures (AGPs) and great care should be taken to protect the surgical team before, during, and after these operations.", "doi": "10.1002/alr.22677", "pmid": "32735062", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-07T16:05:56.221Z", "modified": "2021-02-26T08:45:48.857Z"}, {"entity": "publication", "iuid": "afe9178d3e2f40838664abeb888a2a94", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/afe9178d3e2f40838664abeb888a2a94.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/afe9178d3e2f40838664abeb888a2a94"}}, "title": "Intensive care unit admissions for pregnant and nonpregnant women with coronavirus disease 2019.", "authors": [{"family": "Westgren", "given": "Magnus", "initials": "M"}, {"family": "Acharya", "given": "Ganesh", "initials": "G"}], "type": "letter", "published": "2020-11-00", "journal": {"title": "Am J Obstet Gynecol", "issn": "1097-6868", "volume": "223", "issue": "5", "pages": "779-780", "issn-l": null}, "abstract": null, "doi": "10.1016/j.ajog.2020.07.046", "pmid": "32721395", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0002-9378(20)30777-8"}, {"db": "pmc", "key": "PMC7382351"}], "notes": [], "created": "2020-12-07T16:10:21.169Z", "modified": "2020-12-07T16:10:21.192Z"}, {"entity": "publication", "iuid": "e84db98dcc2d4608b3f67826eaa81562", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e84db98dcc2d4608b3f67826eaa81562.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e84db98dcc2d4608b3f67826eaa81562"}}, "title": "In silico drug discovery of major metabolites from spices as SARS-CoV-2 main protease inhibitors.", "authors": [{"family": "Ibrahim", "given": "Mahmoud A A", "initials": "MAA"}, {"family": "Abdelrahman", "given": "Alaa H M", "initials": "AHM"}, {"family": "Hussien", "given": "Taha A", "initials": "TA"}, {"family": "Badr", "given": "Esraa A A", "initials": "EAA"}, {"family": "Mohamed", "given": "Tarik A", "initials": "TA"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}, {"family": "Pare", "given": "Paul W", "initials": "PW"}, {"family": "Efferth", "given": "Thomas", "initials": "T"}, {"family": "Hegazy", "given": "Mohamed-Elamir F", "initials": "MF"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Comput Biol Med", "issn": "1879-0534", "issn-l": null, "volume": "126", "issue": null, "pages": "104046"}, "abstract": "Coronavirus Disease 2019 (COVID-19) is an infectious illness caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), originally identified in Wuhan, China (December 2019) and has since expanded into a pandemic. Here, we investigate metabolites present in several common spices as possible inhibitors of COVID-19. Specifically, 32 compounds isolated from 14 cooking seasonings were examined as inhibitors for SARS-CoV-2 main protease (M pro), which is required for viral multiplication. Using a drug discovery approach to identify possible antiviral leads, in silico molecular docking studies were performed. Docking calculations revealed a high potency of salvianolic acid A and curcumin as Mpro inhibitors with binding energies of -9.7 and -9.2 kcal/mol, respectively. Binding mode analysis demonstrated the ability of salvianolic acid A and curcumin to form nine and six hydrogen bonds, respectively with amino acids proximal to Mpro's active site. Stabilities and binding affinities of the two identified natural spices were calculated over 40 ns molecular dynamics simulations and compared to an antiviral protease inhibitor (lopinavir). Molecular mechanics-generalized Born surface area energy calculations revealed greater salvianolic acid A affinity for the enzyme over curcumin and lopinavir with energies of -44.8, -34.2 and -34.8 kcal/mol, respectively. Using a STRING database, protein-protein interactions were identified for salvianolic acid A included the biochemical signaling genes ACE, MAPK14 and ESR1; and for curcumin, EGFR and TNF. This study establishes salvianolic acid A as an in silico natural product inhibitor against the SARS-CoV-2 main protease and provides a promising inhibitor lead for in vitro enzyme testing.", "doi": "10.1016/j.compbiomed.2020.104046", "pmid": "33065388", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "S0010-4825(20)30377-2"}, {"db": "pmc", "key": "PMC7543985"}], "notes": [], "created": "2020-12-01T17:08:08.474Z", "modified": "2021-02-26T08:45:25.924Z"}, {"entity": "publication", "iuid": "fc7c4566185d4cc0bffd118dcbad5cbf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc7c4566185d4cc0bffd118dcbad5cbf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc7c4566185d4cc0bffd118dcbad5cbf"}}, "title": "Impacts of COVID-19 on public transport ridership in Sweden: Analysis of ticket validations, sales and passenger counts.", "authors": [{"family": "Jenelius", "given": "Erik", "initials": "E"}, {"family": "Cebecauer", "given": "Matej", "initials": "M"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Transp Res Interdiscip Perspect", "issn": "2590-1982", "issn-l": null, "volume": "8", "issue": null, "pages": "100242"}, "abstract": "The paper analyses the impacts of COVID-19 on daily public transport ridership in the three most populated regions of Sweden (Stockholm, V\u00e4stra G\u00f6taland and Sk\u00e5ne) during spring 2020. The analysis breaks down the overall ridership with respect to ticket types, youths and seniors, and transport modes based on ticket validations, sales and passenger counts data. By utilizing disaggregate ticket validation data with consistent card ids we further investigate to what extent fewer people travelled, or each person travelled less, during the pandemic. The decrease in public transport ridership (40%-60% across regions) was severe compared with other transport modes. Ridership was not restricted by service levels as supply generally remained unchanged throughout the period. The ridership reduction stems primarily from a lower number of active public transport travellers. Travellers switched from monthly period tickets to single tickets and travel funds, while the use and the sales of short period tickets, used predominantly by tourists, dropped to almost zero. One-year period tickets and school tickets increased from mid-April, which could indicate that the travellers using these tickets are particularly captive to the public transport system. Collaborative effort is required to put the results in the international context.", "doi": "10.1016/j.trip.2020.100242", "pmid": "34173478", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S2590-1982(20)30153-6"}, {"db": "pmc", "key": "PMC7575262"}], "notes": [], "created": "2021-06-28T18:10:46.293Z", "modified": "2022-11-09T08:33:38.780Z"}, {"entity": "publication", "iuid": "9bbc433be67043b186493edb7eae38df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9bbc433be67043b186493edb7eae38df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9bbc433be67043b186493edb7eae38df"}}, "title": "Human recombinant soluble ACE2 in severe COVID-19.", "authors": [{"family": "Zoufaly", "given": "Alexander", "initials": "A"}, {"family": "Poglitsch", "given": "Marko", "initials": "M"}, {"family": "Aberle", "given": "Judith H", "initials": "JH"}, {"family": "Hoepler", "given": "Wolfgang", "initials": "W"}, {"family": "Seitz", "given": "Tamara", "initials": "T"}, {"family": "Traugott", "given": "Marianna", "initials": "M"}, {"family": "Grieb", "given": "Alexander", "initials": "A"}, {"family": "Pawelka", "given": "Erich", "initials": "E"}, {"family": "Laferl", "given": "Hermann", "initials": "H"}, {"family": "Wenisch", "given": "Christoph", "initials": "C"}, {"family": "Neuhold", "given": "Stephanie", "initials": "S"}, {"family": "Haider", "given": "Doris", "initials": "D"}, {"family": "Stiasny", "given": "Karin", "initials": "K"}, {"family": "Bergthaler", "given": "Andreas", "initials": "A"}, {"family": "Puchhammer-Stoeckl", "given": "Elisabeth", "initials": "E"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Montserrat", "given": "Nuria", "initials": "N"}, {"family": "Zhang", "given": "Haibo", "initials": "H"}, {"family": "Slutsky", "given": "Arthur S", "initials": "AS"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}], "type": "case reports", "published": "2020-11-00", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "volume": "8", "issue": "11", "pages": "1154-1158", "issn-l": "2213-2600"}, "abstract": "Case report", "doi": "10.1016/S2213-2600(20)30418-5", "pmid": "33131609", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(20)30418-5"}, {"db": "pmc", "key": "PMC7515587"}], "notes": [], "created": "2020-11-27T10:17:02.154Z", "modified": "2021-01-22T12:06:19.752Z"}, {"entity": "publication", "iuid": "7557f87aee3a4ff6a775af1a300c884c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7557f87aee3a4ff6a775af1a300c884c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7557f87aee3a4ff6a775af1a300c884c"}}, "title": "Fact vs Fallacy: The Anti-Vaccine Discussion Reloaded.", "authors": [{"family": "Stolle", "given": "Lucas B", "initials": "LB"}, {"family": "Nalamasu", "given": "Rohit", "initials": "R"}, {"family": "Pergolizzi", "given": "Joseph V", "initials": "JV"}, {"family": "Varrassi", "given": "Giustino", "initials": "G"}, {"family": "Magnusson", "given": "Peter", "initials": "P"}, {"family": "LeQuang", "given": "JoAnn", "initials": "J"}, {"family": "Breve", "given": "Frank", "initials": "F"}, {"family": "NEMA Research Group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Adv Ther", "issn": "1865-8652", "volume": "37", "issue": "11", "pages": "4481-4490", "issn-l": "0741-238X"}, "abstract": "In the light of the COVID-19 pandemic, anti-vaccine sentiments have been on the rise, with a recent seminal study on the development of anti-vaccine views in social media even making its way into Nature Communications. Yet, with the current scientific consensus being in overwhelming agreement over the safety and efficacy of vaccines, many scientists lose their grasp on the fears, concerns, and arguments that the opposition may hold. This paper discusses and evaluates vaccine-hesitant individuals on a socioeconomic, historical, and philosophical landscape. It also provides an analysis of common argumentative patterns and the psychological impact that these arguments may have on undecided individuals. The discussion also explores why anti-vaccine sentiments are on the rise, and how members of the scientific and medical community require a more structured approach to communicating key arguments. This is particularly important if vaccination rates and herd immunity are to be sustained. No longer is it sufficient to win arguments based on a factual and scientific basis, but rather scientists and medical practitioners have to focus on conveying confidence and reassurance on both an informative and emotional level to those with doubts and fears.", "doi": "10.1007/s12325-020-01502-y", "pmid": "32965654", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1007/s12325-020-01502-y"}, {"db": "pmc", "key": "PMC7509825"}], "notes": [], "created": "2020-11-22T09:53:01.112Z", "modified": "2020-11-22T09:53:01.131Z"}, {"entity": "publication", "iuid": "72403b0041cd47e1bd619539665ce532", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/72403b0041cd47e1bd619539665ce532.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/72403b0041cd47e1bd619539665ce532"}}, "title": "Excess deaths from COVID-19 correlate with age and socio-economic status. A database study in the Stockholm region.", "authors": [{"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "F\u00fcrst", "given": "Per", "initials": "P"}, {"family": "Schultz", "given": "Torbj\u00f6rn", "initials": "T"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Ups J Med Sci", "issn": "2000-1967", "issn-l": "0300-9734", "volume": "125", "issue": "4", "pages": "297-304"}, "abstract": "The COVID-19 pandemic has affected the entire health care system, internationally as well as in Sweden. We aimed to study excess deaths (all death causes, but also COVID-19-related deaths) during the COVID-19 pandemic regarding age, socio-economic status, the situation in nursing homes, and place of death for nursing home residents.\r\n\r\nWe performed a descriptive regional registry data study using VAL, the Stockholm Regional Council's central data warehouse, which covers almost all health care use in the county of Stockholm. T tests and chi-square tests were used for comparisons.\r\n\r\nCompared with 2016-2019, there were excess deaths in March-May 2020 ( p < 0.0001), mainly explained by COVID-19, but in April there were also unexplained excess deaths. Individuals dying from COVID-19 were older than patients dying from other causes (p < 0.0001). There were more patient deaths among people residing in less advantaged socio-economic areas (p < 0.0001). Nursing home residents dying from COVID-19 were more often admitted to acute hospitals than residents dying from other causes (p < 0.0001). Also, the proportion of admissions of nursing home residents dying from other causes increased from April to May 2020 (p < 0.0001).\r\n\r\nDying from COVID-19 mainly affects the elderly, nursing home residents, and persons from less advantaged socio-economic groups. The pandemic has resulted in an increase in acute admissions of dying nursing home residents to acute hospitals.", "doi": "10.1080/03009734.2020.1828513", "pmid": "33100083", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7594844"}], "notes": [], "created": "2020-12-01T15:28:20.193Z", "modified": "2022-11-09T08:34:37.083Z"}, {"entity": "publication", "iuid": "60ce9a3171084603b2c06be19e4deb20", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60ce9a3171084603b2c06be19e4deb20.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60ce9a3171084603b2c06be19e4deb20"}}, "title": "Estimation of global case fatality rate of coronavirus disease 2019 (COVID-19) using meta-analyses: Comparison between calendar date and days since the outbreak of the first confirmed case.", "authors": [{"family": "Ghayda", "given": "Ramy Abou", "initials": "RA"}, {"family": "Lee", "given": "Keum Hwa", "initials": "KH"}, {"family": "Han", "given": "Young Joo", "initials": "YJ"}, {"family": "Ryu", "given": "Seohyun", "initials": "S"}, {"family": "Hong", "given": "Sung Hwi", "initials": "SH"}, {"family": "Yoon", "given": "Sojung", "initials": "S"}, {"family": "Jeong", "given": "Gwang Hun", "initials": "GH"}, {"family": "Lee", "given": "Jinhee", "initials": "J"}, {"family": "Lee", "given": "Jun Young", "initials": "JY"}, {"family": "Yang", "given": "Jae Won", "initials": "JW"}, {"family": "Effenberger", "given": "Maria", "initials": "M"}, {"family": "Eisenhut", "given": "Michael", "initials": "M"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Solmi", "given": "Marco", "initials": "M"}, {"family": "Li", "given": "Han", "initials": "H"}, {"family": "Jacob", "given": "Louis", "initials": "L"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Shin", "given": "Jae Il", "initials": "JI"}, {"family": "Smith", "given": "Lee", "initials": "L"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "volume": "100", "issue": null, "pages": "302-308", "issn-l": "1201-9712"}, "abstract": "Since the outbreak of the coronavirus disease 2019 (COVID-19) in December of 2019 in China, estimating the pandemic's case fatality rate (CFR) has been the focus and interest of many stakeholders. In this manuscript, we prove that the method of using the cumulative CFR is static and does not reflect the trend according to the daily change per unit of time.\n\nA proportion meta-analysis was carried out on the CFR in every country reporting COVID-19 cases. Based on these results, we performed a meta-analysis for a global COVID-19 CFR. Each analysis was performed using two different calculations of CFR: according to the calendar date and according to the days since the outbreak of the first confirmed case. We thus explored an innovative and original calculation of CFR, concurrently based on the date of the first confirmed case as well as on a daily basis.\n\nFor the first time, we showed that using meta-analyses according to the calendar date and days since the outbreak of the first confirmed case, were different.\n\nWe propose that a CFR according to days since the outbreak of the first confirmed case might be a better predictor of the current CFR of COVID-19 and its kinetics.", "doi": "10.1016/j.ijid.2020.08.065", "pmid": "32882434", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(20)30694-9"}, {"db": "pmc", "key": "PMC7462556"}], "notes": [], "created": "2020-12-06T07:31:00.699Z", "modified": "2021-02-26T08:46:13.165Z"}, {"entity": "publication", "iuid": "f1cbe1efc1c1422ca2c02154a1dd7af5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f1cbe1efc1c1422ca2c02154a1dd7af5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f1cbe1efc1c1422ca2c02154a1dd7af5"}}, "title": "Establishment of a high-dependency unit in Malawi.", "authors": [{"family": "Morton", "given": "Ben", "initials": "B"}, {"family": "Banda", "given": "Ndaziona Peter", "initials": "NP"}, {"family": "Nsomba", "given": "Edna", "initials": "E"}, {"family": "Ngoliwa", "given": "Clara", "initials": "C"}, {"family": "Antoine", "given": "Sandra", "initials": "S"}, {"family": "Gondwe", "given": "Joel", "initials": "J"}, {"family": "Limbani", "given": "Felix", "initials": "F"}, {"family": "Henrion", "given": "Marc Yves Romain", "initials": "MYR"}, {"family": "Chirombo", "given": "James", "initials": "J"}, {"family": "Baker", "given": "Tim", "initials": "T"}, {"family": "Kamalo", "given": "Patrick", "initials": "P"}, {"family": "Phiri", "given": "Chimota", "initials": "C"}, {"family": "Masamba", "given": "Leo", "initials": "L"}, {"family": "Phiri", "given": "Tamara", "initials": "T"}, {"family": "Mallewa", "given": "Jane", "initials": "J"}, {"family": "Mwandumba", "given": "Henry Charles", "initials": "HC"}, {"family": "Mndolo", "given": "Kwazizira Samson", "initials": "KS"}, {"family": "Gordon", "given": "Stephen", "initials": "S"}, {"family": "Rylance", "given": "Jamie", "initials": "J"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "5", "issue": "11", "issn-l": "2059-7908"}, "abstract": "Adults admitted to hospital with critical illness are vulnerable and at high risk of morbidity and mortality, especially in sub-Saharan African settings where resources are severely limited. As life expectancy increases, patient demographics and healthcare needs are increasingly complex and require integrated approaches. Patient outcomes could be improved by increased critical care provision that standardises healthcare delivery, provides specialist staff and enhanced patient monitoring and facilitates some treatment modalities for organ support. In Malawi, we established a new high-dependency unit within Queen Elizabeth Central Hospital, a tertiary referral centre serving the country's Southern region. This unit was designed in partnership with managers, clinicians, nurses and patients to address their needs. In this practice piece, we describe a participatory approach to design and implement a sustainable high-dependency unit for a low-income sub-Saharan African setting. This included: prospective agreement on remit, alignment with existing services, refurbishment of a dedicated physical space, recruitment and training of specialist nurses, development of context-sensitive clinical standard operating procedures, purchase of appropriate and durable equipment and creation of digital clinical information systems. As the global COVID-19 pandemic unfolded, we accelerated unit opening in anticipation of increased clinical requirement and describe how the high-dependency unit responded to this demand.", "doi": "10.1136/bmjgh-2020-004041", "pmid": "33214176", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-004041"}], "notes": [], "created": "2020-11-26T12:32:03.207Z", "modified": "2020-11-26T12:32:03.217Z"}, {"entity": "publication", "iuid": "b0eb6187940d41ffbfe6bc0ce016018e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b0eb6187940d41ffbfe6bc0ce016018e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b0eb6187940d41ffbfe6bc0ce016018e"}}, "title": "Early impact of COVID-19 on individuals with self-reported eating disorders: A survey of ~1,000 individuals in the United States and the Netherlands.", "authors": [{"family": "Termorshuizen", "given": "Jet D", "initials": "JD"}, {"family": "Watson", "given": "Hunna J", "initials": "HJ"}, {"family": "Thornton", "given": "Laura M", "initials": "LM"}, {"family": "Borg", "given": "Stina", "initials": "S"}, {"family": "Flatt", "given": "Rachael E", "initials": "RE"}, {"family": "MacDermod", "given": "Casey M", "initials": "CM"}, {"family": "Harper", "given": "Lauren E", "initials": "LE"}, {"family": "van Furth", "given": "Eric F", "initials": "EF"}, {"family": "Peat", "given": "Christine M", "initials": "CM"}, {"family": "Bulik", "given": "Cynthia M", "initials": "CM"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Int J Eat Disord", "issn": "1098-108X", "issn-l": null, "volume": "53", "issue": "11", "pages": "1780-1790"}, "abstract": "We evaluated the early impact of COVID-19 on people with self-reported eating disorders.\r\n\r\nParticipants in the United States (US, N = 511) and the Netherlands (NL, N = 510), recruited through ongoing studies and social media, completed an online survey that included both quantitative measures and free-text responses assessing the impact of COVID-19 on situational circumstances, eating disorder symptoms, eating disorder treatment, and general well-being.\r\n\r\nResults revealed strong and wide-ranging effects on eating disorder concerns and illness behaviors that were consistent with eating disorder type. Participants with anorexia nervosa (US 62% of sample; NL 69%) reported increased restriction and fears about being able to find foods consistent with their meal plan. Individuals with bulimia nervosa and binge-eating disorder (US 30% of sample; NL 15%) reported increases in their binge-eating episodes and urges to binge. Respondents noted marked increases in anxiety since 2019 and reported greater concerns about the impact of COVID-19 on their mental health than physical health. Although many participants acknowledged and appreciated the transition to telehealth, limitations of this treatment modality for this population were raised. Individuals with past histories of eating disorders noted concerns about relapse related to COVID-19 circumstances. Encouragingly, respondents also noted positive effects including greater connection with family, more time for self-care, and motivation to recover.\r\n\r\nCOVID-19 is associated with increased anxiety and poses specific disorder-related challenges for individuals with eating disorders that require attention by healthcare professionals and carers.", "doi": "10.1002/eat.23353", "pmid": "32720399", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-07T16:11:16.707Z", "modified": "2022-11-09T08:36:27.009Z"}, {"entity": "publication", "iuid": "9bfe22c6f8c743c580a6feed3b78f8eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9bfe22c6f8c743c580a6feed3b78f8eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9bfe22c6f8c743c580a6feed3b78f8eb"}}, "title": "Do point-of-care tests (POCTs) offer a new paradigm for the management of patients with influenza?", "authors": [{"family": "Dickson", "given": "Elizabeth M", "initials": "EM"}, {"family": "Zambon", "given": "Maria", "initials": "M"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "de Lusignan", "given": "Simon", "initials": "S"}, {"family": "Elliot", "given": "Alex J", "initials": "AJ"}, {"family": "Ellis", "given": "Joanna", "initials": "J"}, {"family": "Lackenby", "given": "Angie", "initials": "A"}, {"family": "Smith", "given": "Gillian", "initials": "G"}, {"family": "McMenamin", "given": "Jim", "initials": "J"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "44", "issn-l": null}, "abstract": "The introduction of point-of-care tests (POCTs) has presented new opportunities for the management of patients presenting to healthcare providers with acute respiratory symptoms. This Perspective article is based on the experiences of national infection teams/those managing acute respiratory infections across the United Kingdom in terms of the challenges and opportunities that this may present for public health. This Perspective article was conceived and written pre-coronavirus disease (COVID-19), however the principles we outline here for influenza can also be translated to COVID-19 and some key points are made throughout the article. The greatest challenge for intergrating POCTs into non-traditional environments is the capture of data and samples for surveillance purposes which provides information for public health action. However, POCTs together with measures outlined in this article, offer a new paradigm for the management and public health surveillance of patients with influenza.", "doi": "10.2807/1560-7917.ES.2020.25.44.1900420", "pmid": "33153522", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7645971"}], "notes": [], "created": "2020-12-01T14:46:59.334Z", "modified": "2020-12-01T14:46:59.344Z"}, {"entity": "publication", "iuid": "83ed1f8cf17b401996eda78f45153f36", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/83ed1f8cf17b401996eda78f45153f36.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/83ed1f8cf17b401996eda78f45153f36"}}, "title": "Did location-based games motivate players to socialize during COVID-19?", "authors": [{"family": "Laato", "given": "Samuli", "initials": "S"}, {"family": "Islam", "given": "A K M Najmul", "initials": "AKMN"}, {"family": "Laine", "given": "Teemu H", "initials": "TH"}], "type": "journal-article", "published": "2020-11-00", "journal": {"title": "Telematics and Informatics", "issn": "0736-5853", "issn-l": null, "volume": "54", "issue": null, "pages": "101458"}, "abstract": null, "doi": "10.1016/j.tele.2020.101458", "pmid": null, "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-12-12T06:54:26.640Z", "modified": "2022-11-09T08:38:07.029Z"}, {"entity": "publication", "iuid": "7509e78a75f94b1283539b1fe33942d7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7509e78a75f94b1283539b1fe33942d7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7509e78a75f94b1283539b1fe33942d7"}}, "title": "Covid-19 in kidney transplant recipients: a systematic review of the case series available three months into the pandemic.", "authors": [{"family": "Oltean", "given": "Mihai", "initials": "M"}, {"family": "S\u00f8fteland", "given": "John Mackay", "initials": "JM"}, {"family": "Bagge", "given": "Jasmine", "initials": "J"}, {"family": "Ekelund", "given": "Jan", "initials": "J"}, {"family": "Felldin", "given": "Marie", "initials": "M"}, {"family": "Schult", "given": "Andreas", "initials": "A"}, {"family": "Magnusson", "given": "Jesper", "initials": "J"}, {"family": "Friman", "given": "Vanda", "initials": "V"}, {"family": "Karason", "given": "Kristjan", "initials": "K"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Infect Dis (Lond)", "issn": "2374-4243", "volume": "52", "issue": "11", "pages": "830-837", "issn-l": "2374-4235"}, "abstract": "Coronavirus disease 2019 (COVID-19) ranges from a mild illness to acute respiratory distress syndrome (ARDS), multiorgan dysfunction, and death. Transplant recipients are vulnerable due to comorbidities and immunosuppressants that render them susceptible to infections. The information on COVID-19 in kidney transplant recipients remains limited to small case series.\n\nA systematic literature search was conducted, and 12 case series totalling 204 kidney transplant recipients with COVID-19 were identified. Data were extracted, pooled and analysed.\n\nMost patients (74%) were men. The most frequent symptoms were fever (76%), cough (64%) and dyspnoea (43%). At admission, over 70% of the patients had abnormal radiological findings. Leukocyte counts were in the lower normal range. C-reactive protein, ferritin, and D-dimer were consistently increased. Treatments included lowering immunosuppression, hydroxychloroquine, antivirals, tocilizumab and intravenous immunoglobulins. Thirty-one percent of the patients were admitted to intensive care units (ICUs), and 16% required intubation. The overall mortality was 21.2%. Patients who died were significantly older than those who survived (61 \u00b1 12 vs. 51 \u00b1 15, p < .01). Logistic regression revealed that the odds for death increased by 4.3% for each additional year of age (odds ratio [OR] 1.043, 95% confidence interval [CI] 1.005-1.083, p value = .0265).\n\nNo substantial conclusions could be drawn on the efficacy of any particular treatment. More rigorous patient stratification is needed when analysing and reporting data to facilitate future meta-analyses.", "doi": "10.1080/23744235.2020.1792977", "pmid": "32657186", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-30T08:51:24.300Z", "modified": "2020-12-08T14:14:19.150Z"}, {"entity": "publication", "iuid": "a3e7cb41d6e1464a9318407386ba4762", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a3e7cb41d6e1464a9318407386ba4762.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a3e7cb41d6e1464a9318407386ba4762"}}, "title": "Converging pathways in pulmonary fibrosis and Covid-19 - The fibrotic link to disease severity.", "authors": [{"family": "Wig\u00e9n", "given": "Jenny", "initials": "J"}, {"family": "L\u00f6fdahl", "given": "Anna", "initials": "A"}, {"family": "Bjermer", "given": "Leif", "initials": "L"}, {"family": "Elowsson-Rendin", "given": "Linda", "initials": "L"}, {"family": "Westergren-Thorsson", "given": "Gunilla", "initials": "G"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Respir Med X", "issn": "2590-1435", "volume": "2", "issue": null, "pages": "100023", "issn-l": "2590-1435"}, "abstract": "As Covid-19 affects millions of people worldwide, the global health care will encounter an increasing burden of the aftermaths of the disease. Evidence shows that up to a fifth of the patients develop fibrotic tissue in the lung. The SARS outbreak in the early 2000 resulted in chronic pulmonary fibrosis in a subset (around 4%) of the patients, and correlated to reduced lung function and forced expiratory volume (FEV). The similarities between corona virus infections causing SARS and Covid-19 are striking, except that the novel coronavirus, SARS-CoV-2, has proven to have an even higher communicability. This would translate into a large number of patients seeking care for clinical signs of pulmonary fibrosis, given that the Covid-19 pandemic has up till now (Sept 2020) affected around 30 million people. The SARS-CoV-2 is dependent on binding to the angiotensin converting enzyme 2 (ACE2), which is part of the renin-angiotensin system (RAS). Downregulation of ACE2 upon virus binding disturbs downstream activities of RAS resulting in increased inflammation and development of fibrosis. The poor prognosis and risk of developing pulmonary fibrosis are therefore associated with the increased expression of ACE2 in risk groups, such as obesity, heart disorders and aging, conferring plenty of binding opportunity for the virus and subsequently the internalization of ACE2, thus devoiding the enzyme from acting counter-inflammatory and antifibrotic. Identifying pathways that are associated with Covid-19 severity that result in pulmonary fibrosis may enable early diagnosis and individualized treatment for these patients to prevent or reduce irreversible fibrotic damage to the lung.", "doi": "10.1016/j.yrmex.2020.100023", "pmid": "33083782", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2590-1435(20)30010-5"}, {"db": "pmc", "key": "PMC7546672"}], "notes": [], "created": "2020-11-27T11:49:56.303Z", "modified": "2020-11-27T11:49:56.325Z"}, {"entity": "publication", "iuid": "6444d78ee37f4160adc32e3a9816b527", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6444d78ee37f4160adc32e3a9816b527.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6444d78ee37f4160adc32e3a9816b527"}}, "title": "Considerations on biologicals for patients with allergic disease in times of the COVID-19 pandemic: An EAACI statement.", "authors": [{"family": "Vultaggio", "given": "Alessandra", "initials": "A"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Akdis", "given": "Cezmi A", "initials": "CA"}, {"family": "Akdis", "given": "Mubeccel", "initials": "M"}, {"family": "Bavbek", "given": "Sevim", "initials": "S"}, {"family": "Bossios", "given": "Apostolos", "initials": "A"}, {"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Boyman", "given": "Onur", "initials": "O"}, {"family": "Chaker", "given": "Adam M", "initials": "AM"}, {"family": "Chan", "given": "Susan", "initials": "S"}, {"family": "Chatzipetrou", "given": "Alexia", "initials": "A"}, {"family": "Feleszko", "given": "Wojciech", "initials": "W"}, {"family": "Firinu", "given": "Davide", "initials": "D"}, {"family": "Jutel", "given": "Marek", "initials": "M"}, {"family": "Kauppi", "given": "Paula", "initials": "P"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Kolios", "given": "Antonios", "initials": "A"}, {"family": "Kothari", "given": "Akash", "initials": "A"}, {"family": "Kowalski", "given": "Marek L", "initials": "ML"}, {"family": "Matucci", "given": "Andrea", "initials": "A"}, {"family": "Palomares", "given": "Oscar", "initials": "O"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Rogala", "given": "Barbara", "initials": "B"}, {"family": "Untersmayr", "given": "Eva", "initials": "E"}, {"family": "Eiwegger", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Allergy", "issn": "1398-9995", "issn-l": "0105-4538", "volume": "75", "issue": "11", "pages": "2764-2774"}, "abstract": "The outbreak of the SARS-CoV-2-induced coronavirus disease 2019 (COVID-19) pandemic re-shaped doctor-patient interaction and challenged capacities of healthcare systems. It created many issues around the optimal and safest way to treat complex patients with severe allergic disease. A significant number of the patients are on treatment with biologicals, and clinicians face the challenge to provide optimal care during the pandemic. Uncertainty of the potential risks for these patients is related to the fact that the exact sequence of immunological events during SARS-CoV-2 is not known. Severe COVID-19 patients may experience a \"cytokine storm\" and associated organ damage characterized by an exaggerated release of pro-inflammatory type 1 and type 3 cytokines. These inflammatory responses are potentially counteracted by anti-inflammatory cytokines and type 2 responses. This expert-based EAACI statement aims to provide guidance on the application of biologicals targeting type 2 inflammation in patients with allergic disease. Currently, there is very little evidence for an enhanced risk of patients with allergic diseases to develop severe COVID-19. Studies focusing on severe allergic phenotypes are lacking. At present, noninfected patients on biologicals for the treatment of asthma, atopic dermatitis, chronic rhinosinusitis with nasal polyps, or chronic spontaneous urticaria should continue their biologicals targeting type 2 inflammation via self-application. In case of an active SARS-CoV-2 infection, biological treatment needs to be stopped until clinical recovery and SARS-CoV-2 negativity is established and treatment with biologicals should be re-initiated. Maintenance of add-on therapy and a constant assessment of disease control, apart from acute management, are demanded.", "doi": "10.1111/all.14407", "pmid": "32500526", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7300800"}], "notes": [], "created": "2020-12-09T10:37:02.018Z", "modified": "2020-12-11T12:45:39.347Z"}, {"entity": "publication", "iuid": "c16a784427d3471e850b91eee6e6a91d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c16a784427d3471e850b91eee6e6a91d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c16a784427d3471e850b91eee6e6a91d"}}, "title": "Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy.", "authors": [{"family": "Mastellos", "given": "Dimitrios C", "initials": "DC"}, {"family": "Pires da Silva", "given": "Bruno G P", "initials": "BGP"}, {"family": "Fonseca", "given": "Benedito A L", "initials": "BAL"}, {"family": "Fonseca", "given": "Natasha P", "initials": "NP"}, {"family": "Auxiliadora-Martins", "given": "Maria", "initials": "M"}, {"family": "Mastaglio", "given": "Sara", "initials": "S"}, {"family": "Ruggeri", "given": "Annalisa", "initials": "A"}, {"family": "Sironi", "given": "Marina", "initials": "M"}, {"family": "Radermacher", "given": "Peter", "initials": "P"}, {"family": "Chrysanthopoulou", "given": "Akrivi", "initials": "A"}, {"family": "Skendros", "given": "Panagiotis", "initials": "P"}, {"family": "Ritis", "given": "Konstantinos", "initials": "K"}, {"family": "Manfra", "given": "Ilenia", "initials": "I"}, {"family": "Iacobelli", "given": "Simona", "initials": "S"}, {"family": "Huber-Lang", "given": "Markus", "initials": "M"}, {"family": "Nilsson", "given": "Bo", "initials": "B"}, {"family": "Yancopoulou", "given": "Despina", "initials": "D"}, {"family": "Connolly", "given": "E Sander", "initials": "ES"}, {"family": "Garlanda", "given": "Cecilia", "initials": "C"}, {"family": "Ciceri", "given": "Fabio", "initials": "F"}, {"family": "Risitano", "given": "Antonio M", "initials": "AM"}, {"family": "Calado", "given": "Rodrigo T", "initials": "RT"}, {"family": "Lambris", "given": "John D", "initials": "JD"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Clin Immunol", "issn": "1521-7035", "issn-l": "1521-6616", "volume": "220", "issue": null, "pages": "108598"}, "abstract": "Growing clinical evidence has implicated complement as a pivotal driver of COVID-19 immunopathology. Deregulated complement activation may fuel cytokine-driven hyper-inflammation, thrombotic microangiopathy and NET-driven immunothrombosis, thereby leading to multi-organ failure. Complement therapeutics have gained traction as candidate drugs for countering the detrimental consequences of SARS-CoV-2 infection. Whether blockade of terminal complement effectors (C5, C5a, or C5aR1) may elicit similar outcomes to upstream intervention at the level of C3 remains debated. Here we compare the efficacy of the C5-targeting monoclonal antibody eculizumab with that of the compstatin-based C3-targeted drug candidate AMY-101 in small independent cohorts of severe COVID-19 patients. Our exploratory study indicates that therapeutic complement inhibition abrogates COVID-19 hyper-inflammation. Both C3 and C5 inhibitors elicit a robust anti-inflammatory response, reflected by a steep decline in C-reactive protein and IL-6 levels, marked lung function improvement, and resolution of SARS-CoV-2-associated acute respiratory distress syndrome (ARDS). C3 inhibition afforded broader therapeutic control in COVID-19 patients by attenuating both C3a and sC5b-9 generation and preventing FB consumption. This broader inhibitory profile was associated with a more robust decline of neutrophil counts, attenuated neutrophil extracellular trap (NET) release, faster serum LDH decline, and more prominent lymphocyte recovery. These early clinical results offer important insights into the differential mechanistic basis and underlying biology of C3 and C5 inhibition in COVID-19 and point to a broader pathogenic involvement of C3-mediated pathways in thromboinflammation. They also support the evaluation of these complement-targeting agents as COVID-19 therapeutics in large prospective trials.", "doi": "10.1016/j.clim.2020.108598", "pmid": "32961333", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1521-6616(20)30758-0"}, {"db": "pmc", "key": "PMC7501834"}, {"db": "mid", "key": "NIHMS1630767"}], "notes": [], "created": "2020-11-22T09:51:36.660Z", "modified": "2021-02-26T08:45:48.658Z"}, {"entity": "publication", "iuid": "7618b0b3be3a4654afdfe602c1f37d89", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7618b0b3be3a4654afdfe602c1f37d89.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7618b0b3be3a4654afdfe602c1f37d89"}}, "title": "Cell-based therapies for coronavirus disease 2019: proper clinical investigations are essential.", "authors": [{"family": "Khoury", "given": "Maroun", "initials": "M"}, {"family": "Rocco", "given": "Patricia R M", "initials": "PRM"}, {"family": "Phinney", "given": "Donald G", "initials": "DG"}, {"family": "Krampera", "given": "Mauro", "initials": "M"}, {"family": "Martin", "given": "Ivan", "initials": "I"}, {"family": "Viswanathan", "given": "Sowmya", "initials": "S"}, {"family": "Nolta", "given": "Jan A", "initials": "JA"}, {"family": "LeBlanc", "given": "Katarina", "initials": "K"}, {"family": "Galipeau", "given": "Jacques", "initials": "J"}, {"family": "Weiss", "given": "Daniel J", "initials": "DJ"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Cytotherapy", "issn": "1477-2566", "volume": "22", "issue": "11", "pages": "602-605", "issn-l": "1465-3249"}, "abstract": "The serious consequences of the global coronavirus disease 2019 (COVID-19) pandemic have prompted a rapid global response to develop effective therapies that can lessen disease severity in infected patients. Cell-based approaches, primarily using mesenchymal stromal cells (MSCs), have demonstrated a strong safety profile and possible efficacy in patients with acute respiratory distress syndrome (ARDS), but whether these therapies are effective for treating respiratory virus-induced ARDS is unknown. According to the World Health Organization International Clinical Trials Registry Platform and the National Institutes of Health ClinicalTrials.gov databases, 27 clinical investigations of MSC-based cell therapy approaches have begun in China since the onset of the COVID-19 outbreak, with a growing number of academic and industry trials elsewhere as well. Several recent published reports have suggested potential efficacy; however, the available data presented are either anecdotal or from incomplete, poorly controlled investigations. Therefore, although there may be a potential role for MSCs and other cell-based therapies in treatment of COVID-19, these need to be investigated in a rationally designed, controlled approach if safety and efficacy are to be demonstrated accurately. The authors urge that the field proceed by finding a balance between swift experimentation and communication of results and scientifically coherent generation and analysis of clinical data.", "doi": "10.1016/j.jcyt.2020.04.089", "pmid": "32933835", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1465-3249(20)30616-2"}, {"db": "pmc", "key": "PMC7163352"}], "notes": [], "created": "2020-11-26T12:31:43.302Z", "modified": "2020-12-03T15:32:34.772Z"}, {"entity": "publication", "iuid": "ef5fe45bee7c4605946def64196f45a3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef5fe45bee7c4605946def64196f45a3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef5fe45bee7c4605946def64196f45a3"}}, "title": "Can hyperbaric oxygen safely serve as an anti-inflammatory treatment for COVID-19?", "authors": [{"family": "Kjellberg", "given": "Anders", "initials": "A"}, {"family": "De Maio", "given": "Antonio", "initials": "A"}, {"family": "Lindholm", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Med Hypotheses", "issn": "1532-2777", "volume": "144", "issue": null, "pages": "110224", "issn-l": null}, "abstract": "SARS-CoV-2 affects part of the innate immune response and activates an inflammatory cascade stimulating the release of cytokines and chemokines, particularly within the lung. Indeed, the inflammatory response during COVID-19 is likely the cause for the development of acute respiratory distress syndrome (ARDS). Patients with mild symptoms also show significant changes on pulmonary CT-scan suggestive of severe inflammatory involvement.\n\nThe overall hypothesis is that HBO 2 is safe and reduces the inflammatory response in COVID-19 pneumonitis by attenuation of the innate immune system, increase hypoxia tolerance and thereby prevent organ failure and reduce mortality.\n\nHBO 2 is used in clinical practice to treat inflammatory conditions but has not been scientifically evaluated for COVID-19. Experimental and empirical data suggests that HBO2 may reduce inflammatory response in COVID-19. However, there are concerns regarding pulmonary safety in patients with pre-existing viral pneumonitis.\n\nAnecdotes from \"compassionate use\" and two published case reports show promising results.\n\nSmall prospective clinical trials are on the way and we are conducting a randomized clinical trial.", "doi": "10.1016/j.mehy.2020.110224", "pmid": "33254531", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0306-9877(20)31444-4"}], "notes": [], "created": "2020-12-03T08:22:26.149Z", "modified": "2020-12-03T08:23:38.944Z"}, {"entity": "publication", "iuid": "2ed302c1d9094ee7a8728af4c143f3f6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ed302c1d9094ee7a8728af4c143f3f6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ed302c1d9094ee7a8728af4c143f3f6"}}, "title": "COVID-19: risk accumulation among biologically and socially vulnerable older populations.", "authors": [{"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A"}, {"family": "Dekhtyar", "given": "Serhiy", "initials": "S"}, {"family": "Vetrano", "given": "Davide L", "initials": "DL"}, {"family": "Bellander", "given": "Tom", "initials": "T"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Ageing Res Rev", "issn": "1872-9649", "issn-l": "1568-1637", "volume": "63", "issue": null, "pages": "101149"}, "abstract": "Emerging data show that the health and economic impacts of COVID-19 are being disproportionately borne by individuals who are not only biologically, but also socially vulnerable. Based on preliminary data from Sweden and other reports, in this paper we propose a conceptual framework whereby different factors related to biological and social vulnerability may explain the specific COVID-19 burden among older people. There is already some evidence showing large social disparities in the prevention, treatment, prognosis and/or long-term consequences of COVID-19. The remaining question is to what extent these affect older adults specifically. We provide the rationale to address this question with scientific methods and proper study designs, where the interplay between individuals' biomedical status and their social environment is the focus. Only through interdisciplinary research integrating biological, clinical and social data will we be able to provide new insights into the SARS-CoV-2 pandemic and inform actions aimed at reducing older adults' vulnerability to COVID-19 or other similar pandemics in the future.", "doi": "10.1016/j.arr.2020.101149", "pmid": "32818650", "labels": {"Type: Journal article": null, "Topics: Register-based research": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7430278"}, {"db": "pii", "key": "S1568-1637(20)30284-1"}], "notes": [], "created": "2020-11-26T12:20:00.368Z", "modified": "2023-06-19T15:29:09.387Z"}, {"entity": "publication", "iuid": "e3eaabbfa0ec451b8202ccdb29c1d375", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3eaabbfa0ec451b8202ccdb29c1d375.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3eaabbfa0ec451b8202ccdb29c1d375"}}, "title": "COVID-19: minimising contaminated aerosol spreading during CPAP treatment.", "authors": [{"family": "Donaldsson", "given": "Snorri", "initials": "S"}, {"family": "Naver", "given": "Lars", "initials": "L"}, {"family": "Jonsson", "given": "Baldvin", "initials": "B"}, {"family": "Drevhammar", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Arch Dis Child Fetal Neonatal Ed", "issn": "1468-2052", "issn-l": null, "volume": "105", "issue": "6", "pages": "669-671"}, "abstract": "The COVID-19 pandemic has raised concern for healthcare workers getting infected via aerosol from non-invasive respiratory support of infants. Attaching filters that remove viral particles in air from the expiratory limb of continuous positive airway pressure (CPAP) devices should theoretically decrease the risk. However, adding filters to the expiratory limb could add to expiratory resistance and thereby increase the imposed work of breathing (WOB).\r\n\r\nTo evaluate the effects on imposed WOB when attaching filters to the expiratory limb of CPAP devices.\r\n\r\nTwo filters were tested on three CPAP systems at two levels of CPAP in a mechanical lung model. Main outcome was imposed WOB.\r\n\r\nThere was a minor increase in imposed WOB when attaching the filters. The differences between the two filters were small.\r\n\r\nTo minimise contaminated aerosol generation during CPAP treatment, filters can be attached to expiratory tubing with only a minimal increase in imposed WOB in a non-humidified environment. Care has to be taken to avoid filter obstruction and replace filters as recommended.", "doi": "10.1136/archdischild-2020-319431", "pmid": "32669360", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "archdischild-2020-319431"}], "notes": [], "created": "2020-12-07T16:37:43.317Z", "modified": "2021-02-26T08:46:13.555Z"}, {"entity": "publication", "iuid": "7b7fc3cac0ab460f8c23c8110677303f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b7fc3cac0ab460f8c23c8110677303f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b7fc3cac0ab460f8c23c8110677303f"}}, "title": "COVID-19: The immediate response of european academic dental institutions and future implications for dental education.", "authors": [{"family": "Quinn", "given": "Barry", "initials": "B"}, {"family": "Field", "given": "James", "initials": "J"}, {"family": "Gorter", "given": "Ronald", "initials": "R"}, {"family": "Akota", "given": "Ilze", "initials": "I"}, {"family": "Manzanares", "given": "Maria-Cristina", "initials": "MC"}, {"family": "Paganelli", "given": "Corrado", "initials": "C"}, {"family": "Davies", "given": "Julia", "initials": "J"}, {"family": "Dixon", "given": "Jonathan", "initials": "J"}, {"family": "Gabor", "given": "Gerber", "initials": "G"}, {"family": "Amaral Mendes", "given": "Rui", "initials": "R"}, {"family": "Hahn", "given": "Petra", "initials": "P"}, {"family": "Vital", "given": "Sibylle", "initials": "S"}, {"family": "O'Brien", "given": "Judith", "initials": "J"}, {"family": "Murphy", "given": "Denis", "initials": "D"}, {"family": "Tubert-Jeannin", "given": "St\u00e9phanie", "initials": "S"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Eur J Dent Educ", "issn": "1600-0579", "volume": "24", "issue": "4", "pages": "811-814", "issn-l": null}, "abstract": "The COVID-19 pandemic has had an immediate and dramatic impact on dental education. The Association of Dental Education in Europe decided to carry out an investigation to assess the immediate response of European Academic Dental Institutions. An online survey was sent to both member and non-member dental schools to investigate the impact on non-clinical and clinical education, assessment and the well-being/pastoral care measures implemented. The preliminary findings and discussion are presented in this paper, for the responses collected between the 25 March and 5 April 2020. The survey at this time of publication is ongoing, and detailed results can be accessed https://adee.org/covid-19-european-dental-education%E2%80%99s-immediate-response.", "doi": "10.1111/eje.12542", "pmid": "32394605", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7272881"}], "notes": [], "created": "2020-12-10T08:39:33.398Z", "modified": "2021-02-26T08:45:48.363Z"}, {"entity": "publication", "iuid": "c7b5d0c782d34b6b8e7f92788ee11cde", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c7b5d0c782d34b6b8e7f92788ee11cde.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c7b5d0c782d34b6b8e7f92788ee11cde"}}, "title": "COVID-19 puts the Sustainable Development Goals center stage.", "authors": [{"family": "Ottersen", "given": "Ole Petter", "initials": "OP"}, {"family": "Engebretsen", "given": "Eivind", "initials": "E"}], "type": "letter", "published": "2020-11-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "issn-l": "1078-8956", "volume": "26", "issue": "11", "pages": "1672-1673"}, "abstract": "Correspondence", "doi": "10.1038/s41591-020-1094-y", "pmid": "33037423", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-020-1094-y"}], "notes": [], "created": "2020-12-01T17:24:14.636Z", "modified": "2020-12-01T17:24:43.108Z"}, {"entity": "publication", "iuid": "ed9e198eee0a4b77a10da7df00a85602", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed9e198eee0a4b77a10da7df00a85602.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed9e198eee0a4b77a10da7df00a85602"}}, "title": "Age, Frailty, and Comorbidity as Prognostic Factors for Short-Term Outcomes in Patients With Coronavirus Disease 2019 in Geriatric Care.", "authors": [{"family": "H\u00e4gg", "given": "Sara", "initials": "S"}, {"family": "Jylh\u00e4v\u00e4", "given": "Juulia", "initials": "J"}, {"family": "Wang", "given": "Yunzhang", "initials": "Y"}, {"family": "Xu", "given": "Hong", "initials": "H"}, {"family": "Metzner", "given": "Carina", "initials": "C"}, {"family": "Annetorp", "given": "Martin", "initials": "M"}, {"family": "Garcia-Ptacek", "given": "Sara", "initials": "S"}, {"family": "Khedri", "given": "Masih", "initials": "M"}, {"family": "Bostr\u00f6m", "given": "Anne-Marie", "initials": "A"}, {"family": "Kadir", "given": "Ahmadul", "initials": "A"}, {"family": "Johansson", "given": "Anna", "initials": "A"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Eriksdotter", "given": "Maria", "initials": "M"}, {"family": "Cederholm", "given": "Tommy", "initials": "T"}, {"family": "Religa", "given": "Dorota", "initials": "D"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "J Am Med Dir Assoc", "issn": "1538-9375", "issn-l": null, "volume": "21", "issue": "11", "pages": "1555-1559.e2"}, "abstract": "To analyze whether frailty and comorbidities are associated with in-hospital mortality and discharge to home in older adults hospitalized for coronavirus disease 2019 (COVID-19).\r\n\r\nSingle-center observational study.\r\n\r\nPatients admitted to geriatric care in a large hospital in Sweden between March 1 and June 11, 2020; 250 were treated for COVID-19 and 717 for other diagnoses.\r\n\r\nCOVID-19 diagnosis was clinically confirmed by positive reverse transcription polymerase chain reaction test or, if negative, by other methods. Patient data were extracted from electronic medical records, which included Clinical Frailty Scale (CFS), and were further used for assessments of the Hospital Frailty Risk Score (HFRS) and the Charlson Comorbidity Index (CCI). In-hospital mortality and home discharge were followed up for up to 25 and 28 days, respectively. Multivariate Cox regression models adjusted for age and sex were used.\r\n\r\nAmong the patients with COVID-19, in-hospital mortality rate was 24% and home discharge rate was 44%. Higher age was associated with in-hospital mortality (hazard ratio [HR] 1.05 per each year, 95% confidence interval [CI] 1.01\u20121.08) and lower probability of home discharge (HR 0.97, 95% CI 0.95\u20120.99). CFS (>5) and CCI, but not HFRS, were predictive of in-hospital mortality (HR 1.93, 95% CI 1.02\u20123.65 and HR 1.27, 95% CI 1.02\u20121.58, respectively). Patients with CFS >5 had a lower probability of being discharged home (HR 0.38, 95% CI 0.25\u20120.58). CCI and HFRS were not associated with home discharge. In general, effects were more pronounced in men. Acute kidney injury was associated with in-hospital mortality and hypertension with discharge to home. Other comorbidities (diabetes, cardiovascular disease, lung diseases, chronic kidney disease and dementia) were not associated with either outcome.\r\n\r\nOf all geriatric patients with COVID-19, 3 out of 4 survived during the study period. Our results indicate that in addition to age, the level of frailty is a useful predictor of short-term COVID-19 outcomes in geriatric patients.", "doi": "10.1016/j.jamda.2020.08.014", "pmid": "32978065", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S1525-8610(20)30704-0"}, {"db": "pmc", "key": "PMC7427570"}], "notes": [], "created": "2020-12-03T09:52:18.204Z", "modified": "2022-11-09T08:39:52.158Z"}, {"entity": "publication", "iuid": "7628ba6a3c0448c6a81d8b7127f04490", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7628ba6a3c0448c6a81d8b7127f04490.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7628ba6a3c0448c6a81d8b7127f04490"}}, "title": "Addressing Influenza Vaccination in MENA Region during the COVID-19 Pandemic: Decreasing the Effects of the Collision.", "authors": [{"family": "Al Awaidy", "given": "Salah T", "initials": "ST"}, {"family": "Uyaro\u011flu", "given": "O\u011fuz Abdullah", "initials": "OA"}, {"family": "Wannous", "given": "Chadia", "initials": "C"}, {"family": "Tanriover", "given": "Mine Durusu", "initials": "MD"}], "type": "editorial", "published": "2020-11-00", "journal": {"title": "Oman Med J", "issn": "1999-768X", "volume": "35", "issue": "6", "pages": "e200", "issn-l": null}, "abstract": "Editorial", "doi": "10.5001/omj.2020.132", "pmid": "33214914", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "OMJ-35-06-2000198"}, {"db": "pmc", "key": "PMC7653348"}], "notes": [], "created": "2020-11-27T10:42:01.106Z", "modified": "2020-11-27T10:42:29.251Z"}, {"entity": "publication", "iuid": "831466582e8c428088cfc333e39ab798", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/831466582e8c428088cfc333e39ab798.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/831466582e8c428088cfc333e39ab798"}}, "title": "Adapting care for older cancer patients during the COVID-19 pandemic: Recommendations from the International Society of Geriatric Oncology (SIOG) COVID-19 Working Group.", "authors": [{"family": "Battisti", "given": "Nicol\u00f2 Matteo Luca", "initials": "NML"}, {"family": "Mislang", "given": "Anna Rachelle", "initials": "AR"}, {"family": "Cooper", "given": "Lisa", "initials": "L"}, {"family": "O'Donovan", "given": "Anita", "initials": "A"}, {"family": "Audisio", "given": "Riccardo A", "initials": "RA"}, {"family": "Cheung", "given": "Kwok-Leung", "initials": "KL"}, {"family": "Sarri\u00f3", "given": "Regina Giron\u00e9s", "initials": "RG"}, {"family": "Stauder", "given": "Reinhard", "initials": "R"}, {"family": "Soto-Perez-de-Celis", "given": "Enrique", "initials": "E"}, {"family": "Jaklitsch", "given": "Michael", "initials": "M"}, {"family": "Williams", "given": "Grant R", "initials": "GR"}, {"family": "O'Hanlon", "given": "Shane", "initials": "S"}, {"family": "Alam", "given": "Mahmood", "initials": "M"}, {"family": "Cairo", "given": "Clarito", "initials": "C"}, {"family": "Colloca", "given": "Giuseppe", "initials": "G"}, {"family": "Gil", "given": "Luiz Antonio", "initials": "LA"}, {"family": "Sattar", "given": "Schroder", "initials": "S"}, {"family": "Kantilal", "given": "Kumud", "initials": "K"}, {"family": "Russo", "given": "Chiara", "initials": "C"}, {"family": "Lichtman", "given": "Stuart M", "initials": "SM"}, {"family": "Brain", "given": "Etienne", "initials": "E"}, {"family": "Kanesvaran", "given": "Ravindran", "initials": "R"}, {"family": "Wildiers", "given": "Hans", "initials": "H"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "J Geriatr Oncol", "issn": "1879-4076", "volume": "11", "issue": "8", "pages": "1190-1198", "issn-l": null}, "abstract": "The COVID-19 pandemic poses a barrier to equal and evidence-based management of cancer in older adults. The International Society of Geriatric Oncology (SIOG) formed a panel of experts to develop consensus recommendations on the implications of the pandemic on several aspects of cancer care in this age group including geriatric assessment (GA), surgery, radiotherapy, systemic treatment, palliative care and research. Age and cancer diagnosis are significant predictors of adverse outcomes of the COVID-19 infection. In this setting, GA is particularly valuable to drive decision-making. GA may aid estimating physiologic reserve and adaptive capability, assessing risk-benefits of either providing or temporarily withholding treatments, and determining patient preferences to help inform treatment decisions. In a resource-constrained setting, geriatric screening tools may be administered remotely to identify patients requiring comprehensive GA. Tele-health is also crucial to ensure adequate continuity of care and minimize the risk of infection exposure. In general, therapeutic decisions should favor the most effective and least invasive approach with the lowest risk of adverse outcomes. In selected cases, this might require deferring or omitting surgery, radiotherapy or systemic treatments especially where benefits are marginal and alternative safe therapeutic options are available. Ongoing research is necessary to expand knowledge of the management of cancer in older adults. However, the pandemic presents a significant barrier and efforts should be made to ensure equitable access to clinical trials and prospective data collection to elucidate the outcomes of COVID-19 in this population.", "doi": "10.1016/j.jgo.2020.07.008", "pmid": "32709495", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1879-4068(20)30366-0"}, {"db": "pmc", "key": "PMC7365054"}], "notes": [], "created": "2020-11-30T08:44:15.803Z", "modified": "2020-11-30T08:44:15.827Z"}, {"entity": "publication", "iuid": "fc398b4a001242a99d74b29f8994cd26", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc398b4a001242a99d74b29f8994cd26.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc398b4a001242a99d74b29f8994cd26"}}, "title": "ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study.", "authors": [{"family": "Gill", "given": "Dipender", "initials": "D"}, {"family": "Arvanitis", "given": "Marios", "initials": "M"}, {"family": "Carter", "given": "Paul", "initials": "P"}, {"family": "Hern\u00e1ndez Cordero", "given": "Ana I", "initials": "AI"}, {"family": "Jo", "given": "Brian", "initials": "B"}, {"family": "Karhunen", "given": "Ville", "initials": "V"}, {"family": "Larsson", "given": "Susanna C", "initials": "SC"}, {"family": "Li", "given": "Xuan", "initials": "X"}, {"family": "Lockhart", "given": "Sam M", "initials": "SM"}, {"family": "Mason", "given": "Amy", "initials": "A"}, {"family": "Pashos", "given": "Evanthia", "initials": "E"}, {"family": "Saha", "given": "Ashis", "initials": "A"}, {"family": "Tan", "given": "Vanessa Y", "initials": "VY"}, {"family": "Zuber", "given": "Verena", "initials": "V"}, {"family": "Boss\u00e9", "given": "Yohan", "initials": "Y"}, {"family": "Fahle", "given": "Sarah", "initials": "S"}, {"family": "Hao", "given": "Ke", "initials": "K"}, {"family": "Jiang", "given": "Tao", "initials": "T"}, {"family": "Joubert", "given": "Philippe", "initials": "P"}, {"family": "Lunt", "given": "Alan C", "initials": "AC"}, {"family": "Ouwehand", "given": "Willem Hendrik", "initials": "WH"}, {"family": "Roberts", "given": "David J", "initials": "DJ"}, {"family": "Timens", "given": "Wim", "initials": "W"}, {"family": "van den Berge", "given": "Maarten", "initials": "M"}, {"family": "Watkins", "given": "Nicholas A", "initials": "NA"}, {"family": "Battle", "given": "Alexis", "initials": "A"}, {"family": "Butterworth", "given": "Adam S", "initials": "AS"}, {"family": "Danesh", "given": "John", "initials": "J"}, {"family": "Di Angelantonio", "given": "Emanuele", "initials": "E"}, {"family": "Engelhardt", "given": "Barbara E", "initials": "BE"}, {"family": "Peters", "given": "James E", "initials": "JE"}, {"family": "Sin", "given": "Don D", "initials": "DD"}, {"family": "Burgess", "given": "Stephen", "initials": "S"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "R Soc Open Sci", "issn": "2054-5703", "issn-l": null, "volume": "7", "issue": "11", "pages": "200958"}, "abstract": "Angiotensin-converting enzyme 2 (ACE2) and serine protease TMPRSS2 have been implicated in cell entry for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). The expression of ACE2 and TMPRSS2 in the lung epithelium might have implications for the risk of SARS-CoV-2 infection and severity of COVID-19. We use human genetic variants that proxy angiotensin-converting enzyme (ACE) inhibitor drug effects and cardiovascular risk factors to investigate whether these exposures affect lung ACE2 and TMPRSS2 gene expression and circulating ACE2 levels. We observed no consistent evidence of an association of genetically predicted serum ACE levels with any of our outcomes. There was weak evidence for an association of genetically predicted serum ACE levels with ACE2 gene expression in the Lung eQTL Consortium (p = 0.014), but this finding did not replicate. There was evidence of a positive association of genetic liability to type 2 diabetes mellitus with lung ACE2 gene expression in the Gene-Tissue Expression (GTEx) study (p = 4 \u00d7 10-4) and with circulating plasma ACE2 levels in the INTERVAL study (p = 0.03), but not with lung ACE2 expression in the Lung eQTL Consortium study (p = 0.68). There were no associations of genetically proxied liability to the other cardiometabolic traits with any outcome. This study does not provide consistent evidence to support an effect of serum ACE levels (as a proxy for ACE inhibitors) or cardiometabolic risk factors on lung ACE2 and TMPRSS2 expression or plasma ACE2 levels.", "doi": "10.1098/rsos.200958", "pmid": "33391794", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: H2020": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-07T11:18:38.095Z", "modified": "2021-02-26T08:45:48.911Z"}, {"entity": "publication", "iuid": "d1dfa2e8f18249f6a09ed3001da4e273", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1dfa2e8f18249f6a09ed3001da4e273.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1dfa2e8f18249f6a09ed3001da4e273"}}, "title": "A roadmap to the safe practice of forensic medicine in the COVID-19 pandemic.", "authors": [{"family": "Parekh", "given": "Utsav", "initials": "U"}, {"family": "Chariot", "given": "Patrick", "initials": "P"}, {"family": "Dang", "given": "Catherine", "initials": "C"}, {"family": "Stray-Pedersen", "given": "Arne", "initials": "A"}, {"family": "Druid", "given": "Henrik", "initials": "H"}, {"family": "Sajantila", "given": "Antti", "initials": "A"}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "J Forensic Leg Med", "issn": "1878-7487", "volume": "76", "issue": null, "pages": "102036", "issn-l": "1752-928X"}, "abstract": "The COVID-19 pandemic has forced forensic practitioners to consider how we perform our normal duties, especially when those duties involve humans. The potential for contracting the virus from working in close contact with living sufferers is high, and we have yet to fully determine the risk of infection from the deceased. In an attempt to support the community, the Journal of Forensic & Legal Medicine has drawn together three articles which underline the importance of continued forensic medical practice during the pandemic and highlight some factors to consider in a Roadmap towards safe practice. Our Roadmap has intentionally taken an international perspective and supports other work we have published in the Journal on our collective response to the COVID-19 crisis.", "doi": "10.1016/j.jflm.2020.102036", "pmid": "33208233", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1752-928X(20)30143-8"}, {"db": "pmc", "key": "PMC7560269"}], "notes": [], "created": "2020-11-26T12:35:58.300Z", "modified": "2020-11-27T09:50:51.155Z"}, {"entity": "publication", "iuid": "6782ff1d9e184517b9530963a13c83ba", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6782ff1d9e184517b9530963a13c83ba.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6782ff1d9e184517b9530963a13c83ba"}}, "title": "H-WORK Project: Multilevel Interventions to Promote Mental Health in SMEs and Public Workplaces.", "authors": [{"family": "De Angelis", "given": "Marco", "initials": "M"}, {"family": "Giusino", "given": "Davide", "initials": "D"}, {"family": "Nielsen", "given": "Karina", "initials": "K"}, {"family": "Aboagye", "given": "Emmanuel", "initials": "E"}, {"family": "Christensen", "given": "Marit", "initials": "M"}, {"family": "Innstrand", "given": "Siw Tone", "initials": "ST"}, {"family": "Mazzetti", "given": "Greta", "initials": "G"}, {"family": "van den Heuvel", "given": "Machteld", "initials": "M"}, {"family": "Sijbom", "given": "Roy B L", "initials": "RBL"}, {"family": "Pelzer", "given": "Vince", "initials": "V"}, {"family": "Chiesa", "given": "Rita", "initials": "R"}, {"family": "Pietrantoni", "given": "Luca", "initials": "L"}], "type": "journal article", "published": "2020-10-31", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "21", "pages": null}, "abstract": "The paper describes the study design, research questions and methods of a large, international intervention project aimed at improving employee mental health and well-being in SMEs and public organisations. The study is innovative in multiple ways. First, it goes beyond the current debate on whether individual- or organisational-level interventions are most effective in improving employee health and well-being and tests the cumulative effects of multilevel interventions, that is, interventions addressing individual, group, leader and organisational levels. Second, it tailors its interventions to address the aftermaths of the Covid-19 pandemic and develop suitable multilevel interventions for dealing with new ways of working. Third, it uses realist evaluation to explore and identify the working ingredients of and the conditions required for each level of intervention, and their outcomes. Finally, an economic evaluation will assess both the cost-effectiveness analysis and the affordability of the interventions from the employer perspective. The study integrates the training transfer and the organisational process evaluation literature to develop toolkits helping end-users to promote mental health and well-being in the workplace.", "doi": "10.3390/ijerph17218035", "pmid": "33142745", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "ijerph17218035"}, {"db": "pmc", "key": "PMC7662282"}], "notes": [], "created": "2020-11-27T10:14:09.269Z", "modified": "2020-12-01T14:52:50.692Z"}, {"entity": "publication", "iuid": "545c2179da7042fdaa7d12bedd3fc5b8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/545c2179da7042fdaa7d12bedd3fc5b8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/545c2179da7042fdaa7d12bedd3fc5b8"}}, "title": "The COVID-19 pandemic as disjuncture: Lifelong learning in a context of fear.", "authors": [{"family": "Bjursell", "given": "Cecilia", "initials": "C"}], "type": "journal article", "published": "2020-10-30", "journal": {"title": "Int Rev Educ", "issn": "0020-8566", "volume": null, "issue": null, "pages": "1-17", "issn-l": null}, "abstract": "The COVID-19 pandemic has caused a number of fundamental changes in different societies, and can therefore be understood as creating \"disjuncture\" in our lives. Disjuncture is a concept proposed by adult educator Peter Jarvis to describe the phenomenon of what happens when an individual is confronted with an experience that conflicts with her/his previous understanding of the world. Faced with a situation that creates disjuncture, the person is compelled to find new knowledge and new ways of doing things; i.e., he/she must embark on a learning process. The recent introduction of social distancing as a measure aiming to reduce transmission of the COVID-19 virus has dramatically changed people's behaviour, but this measure does not only have preventive and desirable effects. There is an associated risk for increased isolation among the older generations of the population, as well as a change in intergenerational relationships. Although the current pandemic (as disjuncture) may potentially initiate major learning processes in the human collective, we should remember that disjuncture is often theorised within neutral, or even positive, contexts. In a context of fear, however, learning may result in a narrowing of mindsets and a rejection of collective efforts and solidarity between generations. In terms of the types of learning triggered by the current pandemic (as disjuncture), one problem is non-reflective learning, which primarily occurs on a behavioural level. We need to recognise this and engage in reflective learning if we are to make the choices that will lead to a society that is worth living in for all generations. Our goal must be to learn to be a person in a post-pandemic society.", "doi": "10.1007/s11159-020-09863-w", "pmid": "33144741", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "9863"}, {"db": "pmc", "key": "PMC7596631"}], "notes": [], "created": "2020-12-01T14:49:36.708Z", "modified": "2020-12-01T14:49:48.354Z"}, {"entity": "publication", "iuid": "3a127f769d8a486b86f9abc60a8625b6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a127f769d8a486b86f9abc60a8625b6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a127f769d8a486b86f9abc60a8625b6"}}, "title": "Pfam: The protein families database in 2021.", "authors": [{"family": "Mistry", "given": "Jaina", "initials": "J"}, {"family": "Chuguransky", "given": "Sara", "initials": "S"}, {"family": "Williams", "given": "Lowri", "initials": "L"}, {"family": "Qureshi", "given": "Matloob", "initials": "M"}, {"family": "Salazar", "given": "Gustavo A", "initials": "GA"}, {"family": "Sonnhammer", "given": "Erik L L", "initials": "ELL"}, {"family": "Tosatto", "given": "Silvio C E", "initials": "SCE"}, {"family": "Paladin", "given": "Lisanna", "initials": "L"}, {"family": "Raj", "given": "Shriya", "initials": "S"}, {"family": "Richardson", "given": "Lorna J", "initials": "LJ"}, {"family": "Finn", "given": "Robert D", "initials": "RD"}, {"family": "Bateman", "given": "Alex", "initials": "A"}], "type": "journal article", "published": "2020-10-30", "journal": {"title": "Nucleic Acids Res", "issn": "1362-4962", "volume": null, "issue": null, "issn-l": "0305-1048"}, "abstract": "The Pfam database is a widely used resource for classifying protein sequences into families and domains. Since Pfam was last described in this journal, over 350 new families have been added in Pfam 33.1 and numerous improvements have been made to existing entries. To facilitate research on COVID-19, we have revised the Pfam entries that cover the SARS-CoV-2 proteome, and built new entries for regions that were not covered by Pfam. We have reintroduced Pfam-B which provides an automatically generated supplement to Pfam and contains 136 730 novel clusters of sequences that are not yet matched by a Pfam family. The new Pfam-B is based on a clustering by the MMseqs2 software. We have compared all of the regions in the RepeatsDB to those in Pfam and have started to use the results to build and refine Pfam repeat families. Pfam is freely available for browsing and download at http://pfam.xfam.org/.", "doi": "10.1093/nar/gkaa913", "pmid": "33125078", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "5943818"}], "notes": [], "created": "2020-12-01T15:03:52.765Z", "modified": "2020-12-01T15:03:52.776Z"}, {"entity": "publication", "iuid": "1b4f51d5b73a4d18a3eb1a4c6b7afa37", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b4f51d5b73a4d18a3eb1a4c6b7afa37.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b4f51d5b73a4d18a3eb1a4c6b7afa37"}}, "title": "Multipel skleros och covid-19 \u2013 kunskapen \u00e4nnu begr\u00e4nsad", "authors": [{"family": "Iacobaeus", "given": "Ellen", "initials": "E"}, {"family": "Burman", "given": "Joachim", "initials": "J"}, {"family": "Landtblom", "given": "Anne-Marie", "initials": "A"}], "type": "journal article", "published": "2020-10-30", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": null, "doi": null, "pmid": "33150577", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "20129"}], "notes": [], "created": "2020-11-27T10:08:24.361Z", "modified": "2020-12-08T07:13:40.676Z"}, {"entity": "publication", "iuid": "65e7ee33ba5642e49ac02b48b23e635e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65e7ee33ba5642e49ac02b48b23e635e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65e7ee33ba5642e49ac02b48b23e635e"}}, "title": "Mathematical Models for COVID-19 Pandemic: A Comparative Analysis.", "authors": [{"family": "Adiga", "given": "Aniruddha", "initials": "A"}, {"family": "Dubhashi", "given": "Devdatt", "initials": "D"}, {"family": "Lewis", "given": "Bryan", "initials": "B"}, {"family": "Marathe", "given": "Madhav", "initials": "M"}, {"family": "Venkatramanan", "given": "Srinivasan", "initials": "S"}, {"family": "Vullikanti", "given": "Anil", "initials": "A"}], "type": "journal article", "published": "2020-10-30", "journal": {"title": "J Indian Inst Sci", "issn": "0970-4140", "volume": null, "issue": null, "pages": "1-15", "issn-l": "0970-4140"}, "abstract": "COVID-19 pandemic represents an unprecedented global health crisis in the last 100 years. Its economic, social and health impact continues to grow and is likely to end up as one of the worst global disasters since the 1918 pandemic and the World Wars. Mathematical models have played an important role in the ongoing crisis; they have been used to inform public policies and have been instrumental in many of the social distancing measures that were instituted worldwide. In this article, we review some of the important mathematical models used to support the ongoing planning and response efforts. These models differ in their use, their mathematical form and their scope.", "doi": "10.1007/s41745-020-00200-6", "pmid": "33144763", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "200"}, {"db": "pmc", "key": "PMC7596173"}], "notes": [], "created": "2020-11-27T11:01:16.970Z", "modified": "2020-12-01T14:48:54.078Z"}, {"entity": "publication", "iuid": "e096c3052ebf45a78d3bb90283e18088", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e096c3052ebf45a78d3bb90283e18088.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e096c3052ebf45a78d3bb90283e18088"}}, "title": "The complex distribution of SARS-CoV-2 in a population invalidates the use of the per capita rates of death and infection in international comparisons.", "authors": [{"family": "Silva", "given": "W T A F", "initials": "WTAF"}], "type": "letter", "published": "2020-10-29", "journal": {"title": "Public Health", "issn": "1476-5616", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.puhe.2020.10.019", "pmid": "33334594", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0033-3506(20)30461-3"}, {"db": "pmc", "key": "PMC7598416"}], "notes": [], "created": "2020-12-21T08:56:24.887Z", "modified": "2021-02-26T08:47:00.242Z"}, {"entity": "publication", "iuid": "55e43348983d455fad0063218a676042", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/55e43348983d455fad0063218a676042.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/55e43348983d455fad0063218a676042"}}, "title": "Risk factors for mortality in adult COVID-19 patients; frailty predicts fatal outcome in older patients.", "authors": [{"family": "Tehrani", "given": "Sara", "initials": "S"}, {"family": "Killander", "given": "Anna", "initials": "A"}, {"family": "\u00c5strand", "given": "Per", "initials": "P"}, {"family": "Jakobsson", "given": "Jan", "initials": "J"}, {"family": "Gille-Johnson", "given": "Patrik", "initials": "P"}], "type": "journal article", "published": "2020-10-29", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": null, "issue": null, "pages": null}, "abstract": "This study investigated demographics, co-morbidities and death rate in hospitalized patients with confirmed COVID-19. In addition, we hypothesized that functional status, according to Clinical Frailty Scale (CFS), in patients aged 65 years and older is a better predictor of poor outcome than age and co-morbidities.\r\n\r\nA total of 255 randomly selected COVID-19 patients admitted at a university hospital were included and followed for 60 days. Patient data was extracted manually from the electronic health records using a standardized protocol.\r\n\r\nThe age of the study population ranged between 20 and 103 years, (mean age was 66\u00b117 years). Hypertension, diabetes mellitus and obesity were the three most prevalent co-morbidities. At the 60-day follow-up, 70 patients (27%) had died. In multivariate analyses, age, chronic kidney disease and previous stroke were associated with death. Most fatal cases (90%) occurred in older patients. Among the older patients, CFS was the only predictor of death in multivariate analyses.\r\n\r\nThis study shows that higher age, chronic kidney disease and previous stroke significantly contribute to a fatal outcome in hospitalized patients with COVID-19. In patients aged 65 years and older, CFS was the strongest prognostic factor for mortality.", "doi": "10.1016/j.ijid.2020.10.071", "pmid": "33130213", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(20)32276-1"}], "notes": [], "created": "2020-11-27T10:18:27.233Z", "modified": "2022-11-09T08:41:21.795Z"}, {"entity": "publication", "iuid": "7d0b505b0cde44238632734beb405eaa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d0b505b0cde44238632734beb405eaa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d0b505b0cde44238632734beb405eaa"}}, "title": "Emergency Healthcare Providers' Perceptions of Preparedness and Willingness to Work during Disasters and Public Health Emergencies.", "authors": [{"family": "Sultan", "given": "Mohammed Ali Salem", "initials": "MAS"}, {"family": "L\u00f8we S\u00f8rensen", "given": "Jarle", "initials": "J"}, {"family": "Carlstr\u00f6m", "given": "Eric", "initials": "E"}, {"family": "Mortelmans", "given": "Luc", "initials": "L"}, {"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}], "type": "journal article", "published": "2020-10-29", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "volume": "8", "issue": "4", "issn-l": null}, "abstract": "This study evaluates the perceptions of preparedness and willingness to work during disasters and public health emergencies among 213 healthcare workers at hospitals in the southern region of Saudi Arabia by using a quantitative survey (Fight or Flight). The results showed that participants' willingness to work unconditionally during disasters and emergencies varied based on the type of condition: natural disasters (61.97%), seasonal influenza pandemic (52.58%), smallpox pandemic (47.89%), SARS/COVID-19 pandemic (43.56%), special flu pandemic (36.15%), mass shooting (37.56%), chemical incident and bombing threats (31.92%), biological events (28.17%), Ebola outbreaks (27.7%), and nuclear incident (24.88%). A lack of confidence and the absence of safety assurance for healthcare workers and their family members were the most important reasons cited. The co-variation between age and education versus risk and danger by Spearman's rho confirmed a small negative correlation between education and danger at a 95% level of significance, meaning that educated healthcare workers have less fear to work under dangerous events. Although the causes of unsuccessful management of disasters and emergencies may vary, individuals' characteristics, such as lack of confidence and emotional distractions because of uncertainty about the safety issues, may also play a significant role. Besides educational initiatives, other measures, which guarantee the safety of healthcare providers and their family members, should be established and implemented.", "doi": "10.3390/healthcare8040442", "pmid": "33138164", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "healthcare8040442"}], "notes": [], "created": "2020-12-01T14:59:58.421Z", "modified": "2021-02-26T08:45:48.385Z"}, {"entity": "publication", "iuid": "8dad937a4d5c4d60a37ee7eb0be35ca4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8dad937a4d5c4d60a37ee7eb0be35ca4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8dad937a4d5c4d60a37ee7eb0be35ca4"}}, "title": "The digital immunization system of the future: imagining a patient-centric, interoperable immunization information system.", "authors": [{"family": "Atkinson", "given": "Katherine M", "initials": "KM"}, {"family": "Mithani", "given": "Salima Saleem", "initials": "SS"}, {"family": "Bell", "given": "Cameron", "initials": "C"}, {"family": "Rubens-Augustson", "given": "Taylor", "initials": "T"}, {"family": "Wilson", "given": "Kumanan", "initials": "K"}], "type": "journal article", "published": "2020-10-28", "journal": {"title": "Ther Adv Vaccines Immunother", "issn": "2515-1355", "volume": "8", "issue": null, "pages": "2515135520967203", "issn-l": null}, "abstract": "To ensure the effectiveness of increasingly complex immunization programs in upper-middle and high-income settings, comprehensive information systems are needed to track immunization uptake at individual and population levels. The maturity of cloud systems and mobile technologies has created new possibilities for immunization information systems. In this paper, we describe a vision for the next generation of digital immunization information systems for upper-middle and high-income settings based on our experience in Canada. These systems center on the premise that the public is engaged and informed about the immunization process beyond their interaction with primary care, and that they will be a contributor and auditor of immunization data. The digital immunization system of the future will facilitate reporting of adverse events following immunization, issue digital immunization receipts, permit identification of areas of need and allow for delivery of interventions targeting these areas. Through features like immunization reminders and targeted immunization promotion campaigns, the system will reduce many of the known barriers that influence immunization rates. In light of the global COVID-19 pandemic, adaptive digital public health information systems will be required to guide the rollout and post-market surveillance of the SARS-CoV-2 vaccine.", "doi": "10.1177/2515135520967203", "pmid": "33681700", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1177_2515135520967203"}, {"db": "pmc", "key": "PMC7900792"}], "notes": [], "created": "2021-03-09T15:36:05.453Z", "modified": "2021-03-09T15:36:05.475Z"}, {"entity": "publication", "iuid": "b15ab0bc7c204f5eb3258fdd9c3b38e3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b15ab0bc7c204f5eb3258fdd9c3b38e3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b15ab0bc7c204f5eb3258fdd9c3b38e3"}}, "title": "Similar Clinical Course and Significance of Circulating Innate and Adaptive Immune Cell Counts in STEMI and COVID-19.", "authors": [{"family": "de Dios", "given": "Elena", "initials": "E"}, {"family": "Rios-Navarro", "given": "Cesar", "initials": "C"}, {"family": "Perez-Sole", "given": "Nerea", "initials": "N"}, {"family": "Gavara", "given": "Jose", "initials": "J"}, {"family": "Marcos-Garces", "given": "Victor", "initials": "V"}, {"family": "Rodr\u00edguez", "given": "Enrique", "initials": "E"}, {"family": "Carratal\u00e1", "given": "Arturo", "initials": "A"}, {"family": "Forner", "given": "Maria J", "initials": "MJ"}, {"family": "Navarro", "given": "Jorge", "initials": "J"}, {"family": "Blasco", "given": "Maria L", "initials": "ML"}, {"family": "Bondia", "given": "Elvira", "initials": "E"}, {"family": "Signes-Costa", "given": "Jaime", "initials": "J"}, {"family": "Vila", "given": "Jose M", "initials": "JM"}, {"family": "Forteza", "given": "Maria J", "initials": "MJ"}, {"family": "Chorro", "given": "Francisco J", "initials": "FJ"}, {"family": "Bodi", "given": "Vicente", "initials": "V"}], "type": "journal article", "published": "2020-10-28", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "9", "issue": "11", "issn-l": "2077-0383"}, "abstract": "This study aimed to assess the time course of circulating neutrophil and lymphocyte counts and their ratio (NLR) in ST-segment elevation myocardial infarction (STEMI) and coronavirus disease (COVID)-19 and explore their associations with clinical events and structural damage. Circulating neutrophil, lymphocyte and NLR were sequentially measured in 659 patients admitted for STEMI and in 103 COVID-19 patients. The dynamics detected in STEMI (within a few hours) were replicated in COVID-19 (within a few days). In both entities patients with events and with severe structural damage displayed higher neutrophil and lower lymphocyte counts. In both scenarios, higher maximum neutrophil and lower minimum lymphocyte counts were associated with more events and more severe organ damage. NLR was higher in STEMI and COVID-19 patients with the worst clinical and structural outcomes. A canonical deregulation of the immune response occurs in STEMI and COVID-19 patients. Boosted circulating innate (neutrophilia) and depressed circulating adaptive immunity (lymphopenia) is associated with more events and severe organ damage. A greater understanding of these critical illnesses is pivotal to explore novel alternative therapies.", "doi": "10.3390/jcm9113484", "pmid": "33126723", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "jcm9113484"}], "notes": [], "created": "2020-11-27T10:19:02.909Z", "modified": "2021-02-26T08:45:03.195Z"}, {"entity": "publication", "iuid": "95d2453a375346cab92217de9d6b6367", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/95d2453a375346cab92217de9d6b6367.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/95d2453a375346cab92217de9d6b6367"}}, "title": "Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19?", "authors": [{"family": "Palit", "given": "Partha", "initials": "P"}, {"family": "Chattopadhyay", "given": "Debprasad", "initials": "D"}, {"family": "Thomas", "given": "Sabu", "initials": "S"}, {"family": "Kundu", "given": "Amit", "initials": "A"}, {"family": "Kim", "given": "Hyung Sik", "initials": "HS"}, {"family": "Rezaei", "given": "Nima", "initials": "N"}], "type": "journal article", "published": "2020-10-28", "journal": {"title": "Phytomedicine", "issn": "1618-095X", "volume": null, "issue": null, "pages": "153396", "issn-l": "0944-7113"}, "abstract": "Currently, novel coronavirus disease (Covid-19) outbreak creates global panic across the continents, as people from almost all countries and territories have been affected by this highly contagious viral disease. The scenario is deteriorating due to lack of proper & specific target-oriented pharmacologically safe prophylactic agents or drugs, and or any effective vaccine. drug development is urgently required to back in the normalcy in the community and to combat this pandemic.\n\nThus, we have proposed two novel drug targets, Furin and TMPRSS2, as Covid-19 treatment strategy. We have highlighted this target-oriented novel drug delivery strategy, based on their pathophysiological implication on SARS-CoV-2 infection, as evident from earlier SARS-CoV-1, MERS, and influenza virus infection via host cell entry, priming, fusion, and endocytosis. STUDY DESIGN & METHODS: An earlier study suggested that Furin and TMPRSS2 knockout mice had reduced level of viral load and a lower degree of organ damage such as the lung. The present study thus highlights the promise of some selected novel and potential anti-viral Phytopharmaceutical that bind to Furin and TMPRSS2 as target.\n\nFew of them had shown promising anti-viral response in both preclinical and clinical study with acceptable therapeutic safety-index.\n\nHence, this strategy may limit life-threatening Covid-19 infection and its mortality rate through nano-suspension based intra-nasal or oral nebulizer spray, to treat mild to moderate SARS-COV-2 infection when Furin and TMPRSS2 receptor may initiate to express and activate for processing the virus to cause cellular infection by replication within the host cell and blocking of host-viral interaction.", "doi": "10.1016/j.phymed.2020.153396", "pmid": "33380375", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0944-7113(20)30227-0"}, {"db": "pmc", "key": "PMC7591300"}], "notes": [], "created": "2021-01-07T12:09:39.696Z", "modified": "2021-01-07T12:09:39.707Z"}, {"entity": "publication", "iuid": "101defb34cf1411892223412d5e22d70", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/101defb34cf1411892223412d5e22d70.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/101defb34cf1411892223412d5e22d70"}}, "title": "Impact of COVID-19-Related Lockdown on Psychosocial, Cognitive, and Functional Well-Being in Adults With Down Syndrome.", "authors": [{"family": "Villani", "given": "Emanuele Rocco", "initials": "ER"}, {"family": "Vetrano", "given": "Davide Liborio", "initials": "DL"}, {"family": "Damiano", "given": "Cecilia", "initials": "C"}, {"family": "Paola", "given": "Antonella Di", "initials": "AD"}, {"family": "Ulgiati", "given": "Aurora Maria", "initials": "AM"}, {"family": "Martin", "given": "Lynn", "initials": "L"}, {"family": "Hirdes", "given": "John P", "initials": "JP"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Bernabei", "given": "Roberto", "initials": "R"}, {"family": "Onder", "given": "Graziano", "initials": "G"}, {"family": "Carf\u00ec", "given": "Angelo", "initials": "A"}], "type": "journal article", "published": "2020-10-28", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "issn-l": "1664-0640", "volume": "11", "issue": null, "pages": "578686"}, "abstract": "People with Down Syndrome (DS) have a high prevalence of physical and psychiatric comorbidities and experience early-onset dementia. With the outbreak of CoVID-19 pandemic, strict social isolation measures have been necessary to prevent the spreading of the disease. Effects of this lockdown period on behavior, mood and cognition in people with DS have not been assessed so far. In the present clinical study, we investigated the impact of CoVID-19-related lockdown on psychosocial, cognitive and functional well-being in a sample population of 46 adults with DS. The interRAI Intellectual Disability standardized assessment instrument, which includes measures of social withdrawal, functional impairment, aggressive behavior and depressive symptoms, was used to perform a three time-point evaluation (two pre-lockdown and one post-lockdown) in 37 subjects of the study sample, and a two time point evaluation (one pre- and one post-lockdown) in 9 subjects. Two mixed linear regression models - one before and one after the lockdown - have been fitted for each scale in order to investigate the change in the time-dependent variation of the scores. In the pre-lockdown period, significant worsening over time (i.e., per year) was found for the Depression Rating Scale score (\u03b2 = 0.55; 95% CI 0.34; 0.76). In the post-lockdown period, a significant worsening in social withdrawal (\u03b2 = 3.05, 95% CI 0.39; 5.70), instrumental activities of daily living (\u03b2 = 1.13, 95% CI 0.08; 2.18) and depression rating (\u03b2 = 1.65, 95% CI 0.33; 2.97) scales scores was observed, as was a significant improvement in aggressive behavior (\u03b2 = -1.40, 95% CI -2.69; -0.10). Despite the undoubtful importance of the lockdown in order to reduce the spreading of the CoVID-19 pandemic, the related social isolation measures suggest an exacerbation of depressive symptoms and a worsening in functional status in a sample of adults with DS. At the opposite, aggressive behavior was reduced after the lockdown period. This finding could be related to the increase of negative and depressive symptoms in the study population. Studies with longer follow-up period are needed to assess persistence of these effects.", "doi": "10.3389/fpsyt.2020.578686", "pmid": "33192717", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7655916"}], "notes": [], "created": "2020-11-27T09:55:50.227Z", "modified": "2023-06-19T15:28:57.715Z"}, {"entity": "publication", "iuid": "d019e593ded147cd8a6fa483b8202a56", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d019e593ded147cd8a6fa483b8202a56.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d019e593ded147cd8a6fa483b8202a56"}}, "title": "Emergency department crowding and hospital transformation during COVID-19, a retrospective, descriptive study of a university hospital in Stockholm, Sweden.", "authors": [{"family": "Af Ugglas", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Skyttberg", "given": "Niclas", "initials": "N"}, {"family": "Wladis", "given": "Andreas", "initials": "A"}, {"family": "Dj\u00e4rv", "given": "Therese", "initials": "T"}, {"family": "Holzmann", "given": "Martin J", "initials": "MJ"}], "type": "journal article", "published": "2020-10-28", "journal": {"title": "Scand J Trauma Resusc Emerg Med", "issn": "1757-7241", "volume": "28", "issue": "1", "pages": "107", "issn-l": "1757-7241"}, "abstract": "COVID-19 presents challenges to the emergency care system that could lead to emergency department (ED) crowding. The Huddinge site at the Karolinska university hospital (KH) responded through a rapid transformation of inpatient care capacity together with changing working methods in the ED. The aim is to describe the KH response to the COVID-19 crisis, and how ED crowding, and important input, throughput and output factors for ED crowding developed at KH during a 30-day baseline period followed by the first 60 days of the COVID-19 outbreak in Stockholm Region.\n\nDifferent phases in the development of the crisis were described and identified retrospectively based on major events that changed the conditions for the ED. Results were presented for each phase separately. The outcome ED length of stay (ED LOS) was calculated with mean and 95% confidence intervals. Input, throughput, output and demographic factors were described using distributions, proportions and means. Pearson correlation between ED LOS and emergency ward occupancy by phase was estimated with 95% confidence interval.\n\nAs new working methods were introduced between phase 2 and 3, ED LOS declined from mean (95% CI) 386 (373-399) minutes to 307 (297-317). Imaging proportion was reduced from 29 to 18% and admission rate increased from 34 to 43%. Correlation (95% CI) between emergency ward occupancy and ED LOS by phase was 0.94 (0.55-0.99).\n\nIt is possible to avoid ED crowding, even during extreme and quickly changing conditions by leveraging previously known input, throughput and output factors. One key factor was the change in working methods in the ED with higher competence, less diagnostics and increased focus on rapid clinical admission decisions. Another important factor was the reduction in bed occupancy in emergency wards that enabled a timely admission to inpatient care. A key limitation was the retrospective study design.", "doi": "10.1186/s13049-020-00799-6", "pmid": "33115521", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13049-020-00799-6"}, {"db": "pmc", "key": "PMC7592192"}], "notes": [], "created": "2020-11-27T10:22:02.875Z", "modified": "2021-02-26T08:45:48.728Z"}, {"entity": "publication", "iuid": "cbf9d53589f342709917243e17cdc214", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cbf9d53589f342709917243e17cdc214.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cbf9d53589f342709917243e17cdc214"}}, "title": "Covid-19: risks to healthcare workers and their families.", "authors": [{"family": "Karlsson", "given": "Ulf", "initials": "U"}, {"family": "Fraenkel", "given": "Carl-Johan", "initials": "C"}], "type": "editorial", "published": "2020-10-28", "journal": {"title": "BMJ", "issn": "1756-1833", "issn-l": null, "volume": "371", "issue": null, "pages": "m3944"}, "abstract": "Editorial", "doi": "10.1136/bmj.m3944", "pmid": "33115772", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-01T15:11:01.785Z", "modified": "2020-12-01T15:11:37.521Z"}, {"entity": "publication", "iuid": "12fc3149e6b4409e9a1f725ef4387c4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/12fc3149e6b4409e9a1f725ef4387c4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/12fc3149e6b4409e9a1f725ef4387c4d"}}, "title": "The Impact of the COVID-19 Pandemic and Emergency Distance Teaching on the Psychological Status of University Teachers: A Cross-Sectional Study in Jordan.", "authors": [{"family": "Akour", "given": "Amal", "initials": "A"}, {"family": "Al-Tammemi", "given": "Ala'a B", "initials": "AB"}, {"family": "Barakat", "given": "Muna", "initials": "M"}, {"family": "Kanj", "given": "Rama", "initials": "R"}, {"family": "Fakhouri", "given": "Hussam N", "initials": "HN"}, {"family": "Malkawi", "given": "Ahmad", "initials": "A"}, {"family": "Musleh", "given": "Ghadeer", "initials": "G"}], "type": "journal article", "published": "2020-10-27", "journal": {"title": "Am J Trop Med Hyg", "issn": "1476-1645", "volume": null, "issue": null, "issn-l": "0002-9637"}, "abstract": "The COVID-19 pandemic has struck many countries globally. Jordan has implemented strict nationwide control measures to halt the viral spread, one of which was the closure of universities and shifting to remote teaching. The impact of this pandemic could extend beyond the risk of physical harm to substantial psychological consequences. Our study aimed at assessing 1) psychological status, 2) challenges of distance teaching, and 3) coping activities and pandemic-related concerns among university teachers in Jordan in the midst of COVID-19-related quarantine and control measures. We conducted a cross-sectional study using an anonymous online survey. The measure of psychological distress was obtained using a validated Arabic version of the Kessler Distress Scale (K10). Other information collected included sociodemographic profile, methods used to handle distress, motivation to participate in distance teaching, and challenges of distance teaching as well as the most worrisome issues during this pandemic. Three hundred eighty-two university teachers returned completed surveys. Results of K10 showed that 31.4% of respondents had severe distress and 38.2% had mild to moderate distress. Whereas gender was not associated with distress severity, age had a weak negative correlation (Rho = -0.19, P < 0.0001). Interestingly, most teachers had moderate to high motivation for distance teaching. Engagement with family was the most reported self-coping activity. More than half of the participants were most concerned and fearful about SARS-CoV-2 infection. In conclusion, university teachers have shown to exhibit various levels of psychological distress and challenges during the implementation of precautionary national measures in the battle against COVID-19 in Jordan.", "doi": "10.4269/ajtmh.20-0877", "pmid": "33124547", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-01T15:07:37.597Z", "modified": "2020-12-01T15:07:37.607Z"}, {"entity": "publication", "iuid": "83fad77501a1445eb5aea9d17c557e17", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/83fad77501a1445eb5aea9d17c557e17.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/83fad77501a1445eb5aea9d17c557e17"}}, "title": "On the relationship between BCG coverage and national Covid-19 outcome: could \"heterologous\" herd immunity explain why some countries are better off?", "authors": [{"family": "Lerm", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2020-10-27", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": "288", "issue": "6", "pages": "682-688", "issn-l": null}, "abstract": "The Covid-19 pandemic has affected most parts of the global society since its emergence and the scientific community has been challenged with challenging questions urgently demanding answers. One of the early hypotheses on Covid-19 outcome was that some protection could be offered by the tuberculosis vaccine (BCG) and several clinical studies were initiated along with the emergence of numerous observational studies on the relationship between BCG and Covid-19 severity. In the present work, I demonstrate a strong correlation between the number of years that countries implemented BCG vaccination plans and age-standardised mortality rates during the first months of the pandemic in Europe. Further analyses of age groups in two European countries with comparably few confounding factors and easily identifiable groups of BCG-vaccinated and non-vaccinated subgroups suggest a population-level effect of BCG on national outcomes of Covid-19. This phenomenon of \"heterologous herd immunity\" deserves further investigation, both in epidemiological and experimental studies.", "doi": "10.1111/joim.13198", "pmid": "33107999", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-01T15:17:52.407Z", "modified": "2021-04-28T15:30:30.449Z"}, {"entity": "publication", "iuid": "363ed9df30a74eca934bca383d9cf3b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/363ed9df30a74eca934bca383d9cf3b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/363ed9df30a74eca934bca383d9cf3b4"}}, "title": "Global impact of the COVID-19 pandemic on cytopathology practice: Results from an international survey of laboratories in 23 countries.", "authors": [{"family": "Vigliar", "given": "Elena", "initials": "E"}, {"family": "Cepurnaite", "given": "Rima", "initials": "R"}, {"family": "Alcaraz-Mateos", "given": "Eduardo", "initials": "E"}, {"family": "Ali", "given": "Syed Z", "initials": "SZ"}, {"family": "Baloch", "given": "Zubair W", "initials": "ZW"}, {"family": "Bellevicine", "given": "Claudio", "initials": "C"}, {"family": "Bongiovanni", "given": "Massimo", "initials": "M"}, {"family": "Botsun", "given": "Pavlina", "initials": "P"}, {"family": "Bruzzese", "given": "Dario", "initials": "D"}, {"family": "Bubendorf", "given": "Lukas", "initials": "L"}, {"family": "B\u00fcttner", "given": "Reinhard", "initials": "R"}, {"family": "Canberk", "given": "Sule", "initials": "S"}, {"family": "Capitanio", "given": "Arrigo", "initials": "A"}, {"family": "Casadio", "given": "Chiara", "initials": "C"}, {"family": "Cazacu", "given": "Eugeniu", "initials": "E"}, {"family": "Cochand-Priollet", "given": "Beatrix", "initials": "B"}, {"family": "D'Amuri", "given": "Alessandro", "initials": "A"}, {"family": "Eloy", "given": "Catarina", "initials": "C"}, {"family": "Engels", "given": "Marianne", "initials": "M"}, {"family": "Fadda", "given": "Guido", "initials": "G"}, {"family": "Fontanini", "given": "Gabriella", "initials": "G"}, {"family": "Fulciniti", "given": "Franco", "initials": "F"}, {"family": "Hofman", "given": "Paul", "initials": "P"}, {"family": "Iaccarino", "given": "Antonino", "initials": "A"}, {"family": "Ieni", "given": "Antonio", "initials": "A"}, {"family": "Jiang", "given": "Xiaoyin Sara", "initials": "XS"}, {"family": "Kakudo", "given": "Kennichi", "initials": "K"}, {"family": "Kern", "given": "Izidor", "initials": "I"}, {"family": "Kholova", "given": "Ivana", "initials": "I"}, {"family": "Liu", "given": "Chinhua", "initials": "C"}, {"family": "Lobo", "given": "Anandi", "initials": "A"}, {"family": "Lozano", "given": "Maria D", "initials": "MD"}, {"family": "Malapelle", "given": "Umberto", "initials": "U"}, {"family": "Maleki", "given": "Zahra", "initials": "Z"}, {"family": "Michelow", "given": "Pamela", "initials": "P"}, {"family": "Musayev", "given": "Jamal", "initials": "J"}, {"family": "\u00d6zg\u00fcn", "given": "Gonca", "initials": "G"}, {"family": "Oznur", "given": "Meltem", "initials": "M"}, {"family": "Peir\u00f3 Marqu\u00e9s", "given": "Francisca Maria", "initials": "FM"}, {"family": "Pisapia", "given": "Pasquale", "initials": "P"}, {"family": "Poller", "given": "David", "initials": "D"}, {"family": "Pyzlak", "given": "Michal", "initials": "M"}, {"family": "Robinson", "given": "Betsy", "initials": "B"}, {"family": "Rossi", "given": "Esther Diana", "initials": "ED"}, {"family": "Roy-Chowdhuri", "given": "Sinchita", "initials": "S"}, {"family": "Saieg", "given": "Mauro", "initials": "M"}, {"family": "Savic Prince", "given": "Spasenija", "initials": "S"}, {"family": "Schmitt", "given": "Fernando C", "initials": "FC"}, {"family": "Javier Segu\u00ed Iv\u00e1\u00f1ez", "given": "Francisco", "initials": "F"}, {"family": "\u0160toos-Vei\u0107", "given": "Tajana", "initials": "T"}, {"family": "Sulaieva", "given": "Oksana", "initials": "O"}, {"family": "Sweeney", "given": "Brenda J", "initials": "BJ"}, {"family": "Tuccari", "given": "Giovanni", "initials": "G"}, {"family": "van Velthuysen", "given": "Marie-Louise", "initials": "ML"}, {"family": "VanderLaan", "given": "Paul A", "initials": "PA"}, {"family": "Vielh", "given": "Philippe", "initials": "P"}, {"family": "Viola", "given": "Patrizia", "initials": "P"}, {"family": "Voorham", "given": "Rinus", "initials": "R"}, {"family": "Weynand", "given": "Birgit", "initials": "B"}, {"family": "Zeppa", "given": "Pio", "initials": "P"}, {"family": "Faquin", "given": "William C", "initials": "WC"}, {"family": "Pitman", "given": "Martha Bishop", "initials": "MB"}, {"family": "Troncone", "given": "Giancarlo", "initials": "G"}], "type": "journal article", "published": "2020-10-27", "journal": {"title": "Cancer Cytopathol", "issn": "1934-6638", "volume": null, "issue": null, "issn-l": null}, "abstract": "To the authors' knowledge, the impact of the coronavirus disease 2019 (COVID-19) pandemic on cytopathology practices worldwide has not been investigated formally. In the current study, data from 41 respondents from 23 countries were reported.\n\nData regarding the activity of each cytopathology laboratory during 4 weeks of COVID-19 lockdown were collected and compared with those obtained during the corresponding period in 2019. The overall number and percentage of exfoliative and fine-needle aspiration cytology samples from each anatomic site were recorded. Differences in the malignancy and suspicious rates between the 2 periods were analyzed using a meta-analytical approach.\n\nOverall, the sample volume was lower compared with 2019 (104,319 samples vs 190,225 samples), with an average volume reduction of 45.3% (range, 0.1%-98.0%). The percentage of samples from the cervicovaginal tract, thyroid, and anorectal region was significantly reduced (P < .05). Conversely, the percentage of samples from the urinary tract, serous cavities, breast, lymph nodes, respiratory tract, salivary glands, central nervous system, gastrointestinal tract, pancreas, liver, and biliary tract increased (P < .05). An overall increase of 5.56% (95% CI, 3.77%-7.35%) in the malignancy rate in nongynecological samples during the COVID-19 pandemic was observed. When the suspicious category was included, the overall increase was 6.95% (95% CI, 4.63%-9.27%).\n\nThe COVID-19 pandemic resulted in a drastic reduction in the total number of cytology specimens regardless of anatomic site or specimen type. The rate of malignancy increased, reflecting the prioritization of patients with cancer who were considered to be at high risk. Prospective monitoring of the effect of delays in access to health services during the lockdown period is warranted.", "doi": "10.1002/cncy.22373", "pmid": "33108683", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-01T15:16:41.610Z", "modified": "2020-12-01T15:16:41.634Z"}, {"entity": "publication", "iuid": "0a1734ad80324354b397d4c7f8f4ca2f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a1734ad80324354b397d4c7f8f4ca2f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a1734ad80324354b397d4c7f8f4ca2f"}}, "title": "Frailty and comorbidity in predicting community COVID-19 mortality in the UK Biobank: the effect of sampling", "authors": [{"family": "Mak", "given": "Jonathan K L", "initials": "JKL"}, {"family": "Kuja-Halkola", "given": "Ralf", "initials": "R"}, {"family": "Wang", "given": "Yunzhang", "initials": "Y"}, {"family": "H\u00e4gg", "given": "Sara", "initials": "S"}, {"family": "Jylh\u00e4v\u00e4", "given": "Juulia", "initials": "J"}], "type": "posted-content", "published": "2020-10-27", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.10.22.20217489", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-09T19:30:28.062Z", "modified": "2021-06-09T19:30:46.038Z"}, {"entity": "publication", "iuid": "d780ed20b16b4f81a2bc925a264c0ab8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d780ed20b16b4f81a2bc925a264c0ab8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d780ed20b16b4f81a2bc925a264c0ab8"}}, "title": "Dashboard of Sentiment in Austrian Social Media During COVID-19.", "authors": [{"family": "Pellert", "given": "Max", "initials": "M"}, {"family": "Lasser", "given": "Jana", "initials": "J"}, {"family": "Metzler", "given": "Hannah", "initials": "H"}, {"family": "Garcia", "given": "David", "initials": "D"}], "type": "journal article", "published": "2020-10-26", "journal": {"title": "Front Big Data", "issn": "2624-909X", "volume": "3", "issue": null, "pages": "32", "issn-l": null}, "abstract": "To track online emotional expressions on social media platforms close to real-time during the COVID-19 pandemic, we built a self-updating monitor of emotion dynamics using digital traces from three different data sources in Austria. This allows decision makers and the interested public to assess dynamics of sentiment online during the pandemic. We used web scraping and API access to retrieve data from the news platform derstandard.at, Twitter, and a chat platform for students. We documented the technical details of our workflow to provide materials for other researchers interested in building a similar tool for different contexts. Automated text analysis allowed us to highlight changes of language use during COVID-19 in comparison to a neutral baseline. We used special word clouds to visualize that overall difference. Longitudinally, our time series showed spikes in anxiety that can be linked to several events and media reporting. Additionally, we found a marked decrease in anger. The changes lasted for remarkably long periods of time (up to 12 weeks). We have also discussed these and more patterns and connect them to the emergence of collective emotions. The interactive dashboard showcasing our data is available online at http://www.mpellert.at/covid19_monitor_austria/. Our work is part of a web archive of resources on COVID-19 collected by the Austrian National Library.", "doi": "10.3389/fdata.2020.00032", "pmid": "33693405", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7931924"}, {"db": "URL", "key": "http://www.mpellert.at/covid19_monitor_austria/.", "description": "http://www.mpellert.at/covid19_monitor_austria/."}], "notes": [], "created": "2021-03-12T06:36:40.432Z", "modified": "2021-03-12T06:37:17.326Z"}, {"entity": "publication", "iuid": "7098ed40379b4bd092504e310993f52d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7098ed40379b4bd092504e310993f52d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7098ed40379b4bd092504e310993f52d"}}, "title": "Therapist-Supported Online Interventions for Children and Young People With Tic Disorders: Lessons Learned From a Randomized Controlled Trial and Considerations for Future Practice.", "authors": [{"family": "Chamberlain", "given": "Liam R", "initials": "LR"}, {"family": "Hall", "given": "Charlotte L", "initials": "CL"}, {"family": "Andr\u00e9n", "given": "Per", "initials": "P"}, {"family": "Davies", "given": "E Bethan", "initials": "EB"}, {"family": "Kilgariff", "given": "Joseph", "initials": "J"}, {"family": "Kouzoupi", "given": "Natalia", "initials": "N"}, {"family": "Murphy", "given": "Tara", "initials": "T"}, {"family": "Hollis", "given": "Chris", "initials": "C"}], "type": "journal article", "published": "2020-10-23", "journal": {"title": "JMIR Ment Health", "issn": "2368-7959", "issn-l": null, "volume": "7", "issue": "10", "pages": "e19600"}, "abstract": "In recent years, research into internet-based cognitive behavioral therapy (iCBT) has suggested that therapist-guided digital interventions have greater engagement, adherence, and effectiveness than self-directed digital therapies. While research has focused on the effectiveness of, and adherence to, these interventions, less attention has been paid to their implementation in practice and what aspects of the therapist role support success. An understanding of the key factors related to the therapist role and intervention delivery is required if these iCBTs are to be applied in routine clinical care and outcomes optimized. In light of the coronavirus disease 2019 (COVID-19) pandemic, there is greater emphasis on allowing patients access to remote therapies. We report the experiences and reflections of 4 therapists and their 2 supervisors in delivering an online, therapist-supported intervention in a randomized controlled trial for children and young people with tic disorders (the Online Remote Behavioural Intervention for Tics [ORBIT] trial). Themes discussed include the importance of training, supervision, creating support documents/manuals, and record keeping. Alongside this are communication strategies used by therapists to encourage patient adherence and treatment effectiveness. These include rapport building, treatment personalization, and suggestions for overcoming non-engagement. These reflections offer important considerations for the delivery of iCBTs as well as implications associated with the implementation of these interventions in existing services and future research studies. We share thoughts on where iCBTs may sit in a stepped care model, how services may deal with comorbid conditions, and the potential role of iCBTs in collecting clinical data.", "doi": "10.2196/19600", "pmid": "33095180", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "v7i10e19600"}, {"db": "pmc", "key": "PMC7647804"}], "notes": [], "created": "2020-12-01T15:35:12.013Z", "modified": "2022-11-09T08:42:39.936Z"}, {"entity": "publication", "iuid": "937cc4cd55c042fcb79e0924979ed1e9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/937cc4cd55c042fcb79e0924979ed1e9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/937cc4cd55c042fcb79e0924979ed1e9"}}, "title": "The impact of delirium on outcomes for older adults hospitalised with COVID-19.", "authors": [{"family": "Marengoni", "given": "Alessandra", "initials": "A"}, {"family": "Zucchelli", "given": "Alberto", "initials": "A"}, {"family": "Grande", "given": "Giulia", "initials": "G"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Rizzuto", "given": "Debora", "initials": "D"}], "type": "journal article", "published": "2020-10-23", "journal": {"title": "Age Ageing", "issn": "1468-2834", "volume": "49", "issue": "6", "pages": "923-926", "issn-l": null}, "abstract": "Delirium is a frequent condition in hospitalized older patients and it usually has a negative prognostic value. A direct effect of SARS-COV-2 on the central nervous system (CNS) has been hypothesized.\n\nTo evaluate the presence of delirium in older patients admitted for a suspected diagnosis of COVID-19 and its impact on in-hospital mortality.\n\n91 patients, aged 70-years and older, admitted to an acute geriatric ward in Northern Italy from March 8th to April 17th, 2020.\n\nCOVID-19 cases were confirmed by reverse transcriptase-polymerase chain reaction assay for SARS-Cov-2 RNA from nasal and pharyngeal swabs. Delirium was diagnosed by two geriatricians according to the Diagnostic and Statistical Manual of Mental Disorders V (DMS V) criteria. The number of chronic diseases was calculated among a pre-defined list of 60. The pre-disease Clinical Frailty Scale (CFS) was assessed at hospital admission.\n\nOf the total sample, 39 patients died, 49 were discharged and 3 were transferred to ICU. Twenty-five patients (27.5%) had delirium. Seventy-two percent of patients with delirium died during hospitalization compared to 31.8% of those without delirium. In a multivariate logistic regression model adjusted for potential confounders, patients with delirium were four times more likely to die during hospital stay compared to those without delirium (OR = 3.98;95%CI = 1.05-17.28; p = 0.047).\n\nDelirium is common in older patients with COVID-19 and strongly associated with in-hospital mortality. Regardless of causation, either due to a direct effect of SARS-COV-2 on the CNS or to a multifactorial cause, delirium should be interpreted as an alarming prognostic indicator in older people.", "doi": "10.1093/ageing/afaa189", "pmid": "32821901", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "5894896"}, {"db": "pmc", "key": "PMC7499475"}], "notes": [], "created": "2020-12-04T08:48:39.233Z", "modified": "2021-02-26T08:45:48.468Z"}, {"entity": "publication", "iuid": "c3138d805cb14e17abf439d2118cffb6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3138d805cb14e17abf439d2118cffb6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3138d805cb14e17abf439d2118cffb6"}}, "title": "The COVID-19 pandemic in Norway and Sweden - threats, trust, and impact on daily life: a comparative survey.", "authors": [{"family": "Helsingen", "given": "Lise M", "initials": "LM"}, {"family": "Refsum", "given": "Erle", "initials": "E"}, {"family": "Gj\u00f8stein", "given": "Dagrun Kyte", "initials": "DK"}, {"family": "L\u00f8berg", "given": "Magnus", "initials": "M"}, {"family": "Bretthauer", "given": "Michael", "initials": "M"}, {"family": "Kalager", "given": "Mette", "initials": "M"}, {"family": "Emilsson", "given": "Louise", "initials": "L"}, {"family": "Clinical Effectiveness Research group", "given": "", "initials": ""}], "type": "comparative study", "published": "2020-10-23", "journal": {"title": "BMC Public Health", "issn": "1471-2458", "issn-l": null, "volume": "20", "issue": "1", "pages": "1597"}, "abstract": "Norway and Sweden have similar populations and health care systems, but different reactions to the COVID-19 pandemic. Norway closed educational institutions, and banned sports and cultural activities; Sweden kept most institutions and training facilities open. We aimed to compare peoples' attitudes towards authorities and control measures, and perceived impact of the pandemic and implemented control measures on life in Norway and Sweden.\r\n\r\nAnonymous web-based surveys for individuals age 15 or older distributed through Facebook using the snowball method, in Norway and Sweden from mid-March to mid-April, 2020. The survey contained questions about perceived threat of the pandemic, views on infection control measures, and impact on daily life. We performed descriptive analyses of the responses and compared the two countries.\r\n\r\n3508 individuals participated in the survey (Norway 3000; Sweden 508). 79% were women, the majority were 30-49 years (Norway 60%; Sweden 47%), and about 45% of the participants in both countries had more than 4 years of higher education. Participants had high trust in the health services, but differed in the degree of trust in their government (High trust in Norway 17%; Sweden 37%). More Norwegians than Swedes agreed that school closure was a good measure (Norway 66%; Sweden 18%), that countries with open schools were irresponsible (Norway 65%; Sweden 23%), and that the threat from repercussions of the mitigation measures were large or very large (Norway 71%; Sweden 56%). Both countries had a high compliance with infection preventive measures (> 98%). Many lived a more sedentary life (Norway 69%; Sweden 50%) and ate more (Norway 44%; Sweden 33%) during the pandemic.\r\n\r\nSweden had more trust in the authorities, while Norwegians reported a more negative lifestyle during the pandemic. The level of trust in the health care system and self-reported compliance with preventive measures was high in both countries despite the differences in infection control measures.", "doi": "10.1186/s12889-020-09615-3", "pmid": "33097011", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12889-020-09615-3"}, {"db": "pmc", "key": "PMC7582026"}], "notes": [], "created": "2020-12-01T15:32:31.149Z", "modified": "2022-11-09T08:44:07.033Z"}, {"entity": "publication", "iuid": "82872c1166474c5fa580ddabf22ed3a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82872c1166474c5fa580ddabf22ed3a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82872c1166474c5fa580ddabf22ed3a6"}}, "title": "Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.", "authors": [{"family": "Zhang", "given": "Qian", "initials": "Q", "orcid": 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"researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4db8bd76f8844446b384a40bcf3ecc74.json"}}, {"family": "Lifton", "given": "Richard P", "initials": "RP"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Gorochov", "given": "Guy", "initials": "G"}, {"family": "B\u00e9ziat", "given": "Vivien", "initials": "V", "orcid": "0000-0002-4020-824X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ec4013e8c1f41d3b3590231e846cfc6.json"}}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E", "orcid": "0000-0002-7358-9157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c50d261245743539a5813daffcaab72.json"}}, {"family": "Sancho-Shimizu", "given": "Vanessa", "initials": "V", "orcid": "0000-0002-3519-0727", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c9f496e84c0b40d7a38fb4385005ad19.json"}}, {"family": "Rice", "given": "Charles M", "initials": "CM"}, {"family": "Abel", "given": "Laurent", "initials": "L", "orcid": "0000-0001-7016-6493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fd6c4593c8c492a8dad8e49cb7a832a.json"}}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD", "orcid": "0000-0002-8335-0262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3f0c0bf3c294622a95b062a5db4386d.json"}}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5369fe152ac94b5a81d4f913d85940a7.json"}}, {"family": "Su", "given": "Helen C", "initials": "HC", "orcid": "0000-0002-5582-9110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad550813f03540d9a8240a3d96ad0829.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL", "orcid": "0000-0002-7782-4169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1aca66ab7c39465faf2de03fa8a6722f.json"}}], "type": "journal article", "published": "2020-10-23", "journal": {"title": "Science", "issn": "1095-9203", "issn-l": "0036-8075", "volume": "370", "issue": "6515", "pages": "eabd4570"}, "abstract": "Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern Toll-like receptor 3 (TLR3)- and interferon regulatory factor 7 (IRF7)-dependent type I interferon (IFN) immunity to influenza virus in 659 patients with life-threatening COVID-19 pneumonia relative to 534 subjects with asymptomatic or benign infection. By testing these and other rare variants at these 13 loci, we experimentally defined LOF variants underlying autosomal-recessive or autosomal-dominant deficiencies in 23 patients (3.5%) 17 to 77 years of age. We show that human fibroblasts with mutations affecting this circuit are vulnerable to SARS-CoV-2. Inborn errors of TLR3- and IRF7-dependent type I IFN immunity can underlie life-threatening COVID-19 pneumonia in patients with no prior severe infection.", "doi": "10.1126/science.abd4570", "pmid": "32972995", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "mid", "key": "NIHMS1668514"}, {"db": "pmc", "key": "PMC7857407"}, {"db": "pii", "key": "science.abd4570"}, {"db": "Dryad", "key": "10.5061/dryad.8pk0p2nkk"}], "notes": [], "created": "2020-11-11T07:23:46.873Z", "modified": "2023-06-19T15:36:55.110Z"}, {"entity": "publication", "iuid": "1564e27d38eb434197f567c9358d5f37", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1564e27d38eb434197f567c9358d5f37.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1564e27d38eb434197f567c9358d5f37"}}, "title": "How to ventilate obese patients in the ICU.", "authors": [{"family": "De Jong", "given": "Audrey", "initials": "A"}, {"family": "Wrigge", "given": "Hermann", "initials": "H"}, {"family": "Hedenstierna", "given": "Goran", "initials": "G"}, {"family": "Gattinoni", "given": "Luciano", "initials": "L"}, {"family": "Chiumello", "given": "Davide", "initials": "D"}, {"family": "Frat", "given": "Jean-Pierre", "initials": "JP"}, {"family": "Ball", "given": "Lorenzo", "initials": "L"}, {"family": "Schetz", "given": "Miet", "initials": "M"}, {"family": "Pickkers", "given": "Peter", "initials": "P"}, {"family": "Jaber", "given": "Samir", "initials": "S"}], "type": "journal article", "published": "2020-10-23", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "volume": "46", "issue": "12", "pages": "2423-2435", "issn-l": "0342-4642"}, "abstract": "Obesity is an important risk factor for major complications, morbidity and mortality related to intubation procedures and ventilation in the intensive care unit (ICU). The fall in functional residual capacity promotes airway closure and atelectasis formation. This narrative review presents the impact of obesity on the respiratory system and the key points to optimize airway management, noninvasive and invasive mechanical ventilation in ICU patients with obesity. Non-invasive strategies should first optimize body position with reverse Trendelenburg position or sitting position. Noninvasive ventilation (NIV) is considered as the first-line therapy in patients with obesity having a postoperative acute respiratory failure. Positive pressure pre-oxygenation before the intubation procedure is the method of reference. The use of videolaryngoscopy has to be considered by adequately trained intensivists, especially in patients with several risk factors. Regarding mechanical ventilation in patients with and without acute respiratory distress syndrome (ARDS), low tidal volume (6 ml/kg of predicted body weight) and moderate to high positive end-expiratory pressure (PEEP), with careful recruitment maneuver in selected patients, are advised. Prone positioning is a therapeutic choice in severe ARDS patients with obesity. Prophylactic NIV should be considered after extubation to prevent re-intubation. If obesity increases mortality and risk of ICU admission in the overall population, the impact of obesity on ICU mortality is less clear and several confounding factors have to be taken into account regarding the \"obesity ICU paradox\".", "doi": "10.1007/s00134-020-06286-x", "pmid": "33095284", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-020-06286-x"}, {"db": "pmc", "key": "PMC7582031"}], "notes": [], "created": "2020-11-27T11:47:55.408Z", "modified": "2020-12-01T15:34:43.643Z"}, {"entity": "publication", "iuid": "f321360c50fe488b82ebe569db5f796d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f321360c50fe488b82ebe569db5f796d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f321360c50fe488b82ebe569db5f796d"}}, "title": "Autoantibodies against type I IFNs in patients with life-threatening COVID-19.", "authors": [{"family": "Bastard", "given": "Paul", "initials": "P", "orcid": 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{"family": "Zhang", "given": "Yu", "initials": "Y"}, {"family": "Dorgham", "given": "Karim", "initials": "K", "orcid": "0000-0001-9539-3203", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/343687bcbc014c7880ce47bfc772c00c.json"}}, {"family": "Philippot", "given": "Quentin", "initials": "Q"}, {"family": "Rosain", "given": "J\u00e9r\u00e9mie", "initials": "J"}, {"family": "B\u00e9ziat", "given": "Vivien", "initials": "V", "orcid": "0000-0002-4020-824X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9ec4013e8c1f41d3b3590231e846cfc6.json"}}, {"family": "Manry", "given": "J\u00e9r\u00e9my", "initials": "J", "orcid": "0000-0001-5998-2051", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ba0f830e329042efa24e0bb5bb8dd752.json"}}, {"family": "Shaw", "given": "Elana", "initials": "E", "orcid": "0000-0001-9265-8026", "researcher": {"href": 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"initials": "D", "orcid": "0000-0002-4571-044X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/472ec24aef0a4a81bd7f3372c21c5b01.json"}}, {"family": "Roussel", "given": "Lucie", "initials": "L", "orcid": "0000-0001-5355-702X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7edbf1a2fe08414d9259e6dd3adcd24e.json"}}, {"family": "Vinh", "given": "Donald C", "initials": "DC", "orcid": "0000-0003-1347-7767", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d08bd304d9d43d980914472fa294316.json"}}, {"family": "Tangye", "given": "Stuart G", "initials": "SG", "orcid": "0000-0002-5360-5180", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58d0bf707fc24c139e36ac3d79ced381.json"}}, {"family": "Haerynck", "given": "Filomeen", "initials": "F"}, {"family": "Dalmau", "given": "David", "initials": "D", "orcid": "0000-0003-1936-478X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b04eafe2908b4f758dc3756c852bb794.json"}}, {"family": "Martinez-Picado", "given": "Javier", "initials": "J", "orcid": "0000-0002-4916-2129", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5d7db939b60d47999925369948f30e2b.json"}}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}, {"family": "Nussenzweig", "given": "Michel C", "initials": "MC", "orcid": "0000-0003-0592-8564", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e61ea4596aea42f290126607bd74c2b9.json"}}, {"family": "Boisson-Dupuis", "given": "St\u00e9phanie", "initials": "S", "orcid": "0000-0002-7115-116X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/92c785f151bb490aa85764eb62c0508e.json"}}, {"family": "Rodr\u00edguez-Gallego", "given": "Carlos", "initials": "C", "orcid": "0000-0002-4344-8644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6c66da3a09c42d7925056c90bddedee.json"}}, {"family": "Vogt", "given": "Guillaume", "initials": "G"}, {"family": "Mogensen", "given": "Trine H", "initials": "TH", "orcid": "0000-0002-1853-9704", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/afec82740890482f8b617acee51d2401.json"}}, {"family": "Oler", "given": "Andrew J", "initials": "AJ", "orcid": "0000-0002-6310-0434", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/339a50f3711e47cb97f705498dc4e9da.json"}}, {"family": "Gu", "given": "Jingwen", "initials": "J"}, {"family": "Burbelo", "given": "Peter D", "initials": "PD", "orcid": "0000-0003-1717-048X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/caf17d6e254746ea8dc72213bcc6f65a.json"}}, {"family": "Cohen", "given": "Jeffrey I", "initials": "JI", "orcid": "0000-0003-0238-7176", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f4b3e2ddf0dd40aca09dcdcb2cc7254f.json"}}, {"family": "Biondi", "given": "Andrea", "initials": "A"}, {"family": "Bettini", "given": "Laura Rachele", "initials": "LR", "orcid": "0000-0002-0280-1704", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8b40303f53284f60bf2ec5b774831ae6.json"}}, {"family": "D'Angio", "given": "Mariella", "initials": "M"}, {"family": "Bonfanti", "given": "Paolo", "initials": "P", "orcid": "0000-0001-7289-8823", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52b16f4f4f5c4031a8435f6f17e791c7.json"}}, {"family": "Rossignol", "given": "Patrick", "initials": "P"}, {"family": "Mayaux", "given": "Julien", "initials": "J"}, {"family": "Rieux-Laucat", "given": "Fr\u00e9d\u00e9ric", "initials": "F", "orcid": "0000-0001-7858-7866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/25490c3f0b9b4c299c3d6ae9e52faffb.json"}}, {"family": "Husebye", "given": "Eystein S", "initials": "ES", "orcid": "0000-0002-7886-2976", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a6afa5e34f74d3db1aa66a6afef9724.json"}}, {"family": "Fusco", "given": "Francesca", "initials": "F"}, {"family": "Ursini", "given": "Matilde Valeria", "initials": "MV"}, {"family": "Imberti", "given": "Luisa", "initials": "L"}, {"family": "Sottini", "given": "Alessandra", "initials": "A"}, {"family": "Paghera", "given": "Simone", "initials": "S"}, {"family": "Quiros-Roldan", "given": "Eugenia", "initials": "E"}, {"family": "Rossi", "given": "Camillo", "initials": "C"}, {"family": "Castagnoli", "given": "Riccardo", "initials": "R", "orcid": "0000-0003-0029-9383", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc5b8149bfc34cc99d00f67c27b0d31f.json"}}, {"family": "Montagna", "given": "Daniela", "initials": "D"}, {"family": "Licari", "given": "Amelia", "initials": "A", "orcid": "0000-0002-1773-6482", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5a39e2bbc5714bd78cc6e9116a18143b.json"}}, {"family": "Marseglia", "given": "Gian Luigi", "initials": "GL"}, {"family": "Duval", "given": "Xavier", "initials": "X"}, {"family": "Ghosn", "given": "Jade", "initials": "J"}, {"family": "HGID Lab", "given": "", "initials": ""}, {"family": "NIAID-USUHS Immune Response to COVID Group", "given": "", "initials": ""}, {"family": "COVID Clinicians", "given": "", "initials": ""}, {"family": "COVID-STORM Clinicians", "given": "", "initials": ""}, {"family": "Imagine COVID Group", "given": "", "initials": ""}, {"family": "French COVID Cohort Study Group", "given": "", "initials": ""}, {"family": "Milieu Int\u00e9rieur Consortium", "given": "", "initials": ""}, {"family": "CoV-Contact Cohort", "given": "", "initials": ""}, {"family": "Amsterdam UMC Covid-19 Biobank", "given": "", "initials": ""}, {"family": "COVID Human Genetic Effort", "given": "", "initials": ""}, {"family": "Tsang", "given": "John S", "initials": "JS", "orcid": "0000-0003-3186-3047", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2c9f3d88b94c4754b5fa887e3f29553b.json"}}, {"family": "Goldbach-Mansky", "given": "Raphaela", "initials": "R", "orcid": "0000-0001-7865-5769", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35abe088a9fa478c9bf9c2e1f18a3e1d.json"}}, {"family": "Kisand", "given": "Kai", "initials": "K", "orcid": "0000-0002-5426-4648", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/45ab722bd98b4f23a99c3f07f0ecfa2c.json"}}, {"family": "Lionakis", "given": "Michail S", "initials": "MS"}, {"family": "Puel", "given": "Anne", "initials": "A", "orcid": "0000-0003-2603-0323", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c2bdac14a1d14b8496ffd12dac6df3e5.json"}}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Holland", "given": "Steven M", "initials": "SM", "orcid": "0000-0003-3207-5464", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12c5a29018ef487eb1e09ca7bba4cae6.json"}}, {"family": "Gorochov", "given": "Guy", "initials": "G"}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E", "orcid": "0000-0002-7358-9157", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c50d261245743539a5813daffcaab72.json"}}, {"family": "Rice", "given": "Charles M", "initials": "CM"}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5369fe152ac94b5a81d4f913d85940a7.json"}}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD", "orcid": "0000-0002-8335-0262", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a3f0c0bf3c294622a95b062a5db4386d.json"}}, {"family": "Abel", "given": "Laurent", "initials": "L", "orcid": "0000-0001-7016-6493", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5fd6c4593c8c492a8dad8e49cb7a832a.json"}}, {"family": "Su", "given": "Helen C", "initials": "HC", "orcid": "0000-0002-5582-9110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad550813f03540d9a8240a3d96ad0829.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL", "orcid": "0000-0002-7782-4169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1aca66ab7c39465faf2de03fa8a6722f.json"}}], "type": "journal article", "published": "2020-10-23", "journal": {"title": "Science", "issn": "1095-9203", "issn-l": "0036-8075", "volume": "370", "issue": "6515", "pages": null}, "abstract": "Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-\u03c9 (IFN-\u03c9) (13 patients), against the 13 types of IFN-\u03b1 (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.", "doi": "10.1126/science.abd4585", "pmid": "32972996", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "mid", "key": "NIHMS1668509"}, {"db": "pmc", "key": "PMC7857397"}, {"db": "pii", "key": "science.abd4585"}], "notes": [], "created": "2020-10-28T08:38:59.426Z", "modified": "2023-06-19T15:37:11.302Z"}, {"entity": "publication", "iuid": "960e677d9dea43468a52138dcc29ff17", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/960e677d9dea43468a52138dcc29ff17.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/960e677d9dea43468a52138dcc29ff17"}}, "title": "Abortion regulation in Europe in the era of COVID-19: a spectrum of policy responses.", "authors": [{"family": "Moreau", "given": "Caroline", "initials": "C"}, {"family": "Shankar", "given": "Mridula", "initials": "M"}, {"family": "Glasier", "given": "Anna", "initials": "A"}, {"family": "Cameron", "given": "Sharon", "initials": "S"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}], "type": "journal article", "published": "2020-10-22", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-2009", "volume": null, "issue": null, "issn-l": "2515-1991"}, "abstract": "Unprecedented public health actions restricting movement and non-COVID related health services are likely to have affected abortion care during the pandemic in Europe. In the absence of a common approach to ensure access to this essential health service, we sought to describe the variability of abortion policies during the outbreak in Europe in order to identify strategies that improve availability and access to abortion in times of public health crises.\n\nWe collected information from 46 countries/regions: 31 for which country-experts completed a survey and 15 for which we conducted a desk review. We describe abortion regulations and changes to regulations and practice during the pandemic.\n\nDuring COVID-19, abortions were banned in six countries and suspended in one. Surgical abortion was less available due to COVID-19 in 12 countries/regions and services were not available or delayed for women with COVID-19 symptoms in eleven. No country expanded its gestational limit for abortion. Changes during COVID-19, mostly designed to reduce in-person consultations, occurred in 13 countries/regions. Altogether eight countries/regions provided home medical abortion with mifepristone and misoprostol beyond 9 weeks (from 9 weeks+6 days to 11 weeks+6 days) and 13 countries/regions up to 9 weeks (in some instances only misoprostol could be taken at home). Only six countries/regions offered abortion by telemedicine.\n\nThe lack of a unified policy response to COVID-19 restrictions has widened inequities in abortion access in Europe, but some innovations including telemedicine deployed during the outbreak could serve as a catalyst to ensure continuity and equity of abortion care.", "doi": "10.1136/bmjsrh-2020-200724", "pmid": "33093040", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjsrh-2020-200724"}], "notes": [], "created": "2020-11-26T12:30:40.338Z", "modified": "2020-12-01T15:37:55.328Z"}, {"entity": "publication", "iuid": "ff7d25c1af0a44379275ecec7e145449", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff7d25c1af0a44379275ecec7e145449.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff7d25c1af0a44379275ecec7e145449"}}, "title": "Serum-IgG responses to SARS-CoV-2 after mild and severe COVID-19 infection and analysis of IgG non-responders.", "authors": [{"family": "Marklund", "given": "Emelie", "initials": "E"}, {"family": "Leach", "given": "Susannah", "initials": "S"}, {"family": "Axelsson", "given": "Hannes", "initials": "H"}, {"family": "Nystr\u00f6m", "given": "Kristina", "initials": "K"}, {"family": "Norder", "given": "Hel\u00e9ne", "initials": "H"}, {"family": "Bemark", "given": "Mats", "initials": "M"}, {"family": "Angeletti", "given": "Davide", "initials": "D"}, {"family": "Lundgren", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Andersson", "given": "Lars Magnus", "initials": "LM"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Liljeqvist", "given": "Jan \u00c5ke", "initials": "J\u00c5"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2020-10-21", "journal": {"title": "PLoS One", "issn": "1932-6203", "issn-l": "1932-6203", "volume": "15", "issue": "10", "pages": "e0241104"}, "abstract": "To accurately interpret COVID-19 seroprevalence surveys, knowledge of serum-IgG responses to SARS-CoV-2 with a better understanding of patients who do not seroconvert, is imperative. This study aimed to describe serum-IgG responses to SARS-CoV-2 in a cohort of patients with both severe and mild COVID-19, including extended studies of patients who remained seronegative more than 90 days post symptom onset.\r\n\r\nSARS-CoV-2-specific IgG antibody levels were quantified using two clinically validated and widely used commercial serological assays (Architect, Abbott Laboratories and iFlash 1800, YHLO), detecting antibodies against the spike and nucleocapsid proteins.\r\n\r\nForty-seven patients (mean age 49 years, 38% female) were included. All (15/15) patients with severe symptoms and 29/32 (90.6%) patients with mild symptoms of COVID-19 developed SARS-CoV-2-specific IgG antibodies in serum. Time to seroconversion was significantly shorter (median 11 vs. 22 days, P = 0.04) in patients with severe compared to mild symptoms. Of the three patients without detectable IgG-responses after >90 days, all had detectable virus-neutralizing antibodies and in two, spike-protein receptor binding domain-specific IgG was detected with an in-house assay. Antibody titers were preserved during follow-up and all patients who seroconverted, irrespective of the severity of symptoms, still had detectable IgG levels >75 days post symptom onset.\r\n\r\nPatients with severe COVID-19 both seroconvert earlier and develop higher concentrations of SARS-CoV-2-specific IgG than patients with mild symptoms. Of those patients who not develop detectable IgG antibodies, all have detectable virus-neutralizing antibodies, suggesting immunity. Our results showing that not all COVID-19 patients develop detectable IgG using two validated commercial clinical methods, even over time, are vital for the interpretation of COVID-19 seroprevalence surveys.", "doi": "10.1371/journal.pone.0241104", "pmid": "33085715", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Research Area: Drug discovery and repurposing of drugs": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Biomarkers and systems immunology": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.5281/zenodo.3934336", "description": "https://doi.org/10.5281/zenodo.3934336"}], "notes": [], "created": "2020-10-30T11:44:05.878Z", "modified": "2022-02-14T07:47:22.475Z"}, {"entity": "publication", "iuid": "bfa69afc506849d699357613bce49a49", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bfa69afc506849d699357613bce49a49.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bfa69afc506849d699357613bce49a49"}}, "title": "Digital contact tracing and exposure notification: ethical guidance for trustworthy pandemic management.", "authors": [{"family": "Ranisch", "given": "Robert", "initials": "R"}, {"family": "Nijsingh", "given": "Niels", "initials": "N"}, {"family": "Ballantyne", "given": "Angela", "initials": "A"}, {"family": "van Bergen", "given": "Anne", "initials": "A"}, {"family": "Buyx", "given": "Alena", "initials": "A"}, {"family": "Friedrich", "given": "Orsolya", "initials": "O"}, {"family": "Hendl", "given": "Tereza", "initials": "T"}, {"family": "Marckmann", "given": "Georg", "initials": "G"}, {"family": "Munthe", "given": "Christian", "initials": "C"}, {"family": "Wild", "given": "Verina", "initials": "V"}], "type": "journal article", "published": "2020-10-21", "journal": {"title": "Ethics Inf Technol", "issn": "1388-1957", "volume": null, "issue": null, "pages": "1-10", "issn-l": null}, "abstract": "There is growing interest in contact tracing apps (CT apps) for pandemic management. It is crucial to consider ethical requirements before, while, and after implementing such apps. In this paper, we illustrate the complexity and multiplicity of the ethical considerations by presenting an ethical framework for a responsible design and implementation of CT apps. Using this framework as a starting point, we briefly highlight the interconnection of social and political contexts, available measures of pandemic management, and a multi-layer assessment of CT apps. We will discuss some trade-offs that arise from this perspective. We then suggest that public trust is of major importance for population uptake of contact tracing apps. Hasty, ill-prepared or badly communicated implementations of CT apps will likely undermine public trust, and as such, risk impeding general effectiveness.", "doi": "10.1007/s10676-020-09566-8", "pmid": "33106749", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "9566"}, {"db": "pmc", "key": "PMC7577205"}], "notes": [], "created": "2020-12-01T15:24:55.558Z", "modified": "2020-12-01T15:25:07.393Z"}, {"entity": "publication", "iuid": "6be39116f72544b68d8d9dc7977d08a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6be39116f72544b68d8d9dc7977d08a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6be39116f72544b68d8d9dc7977d08a6"}}, "title": "International Sexual Health And REproductive health (I-SHARE) survey during COVID-19: study protocol for online national surveys and global comparative analyses.", "authors": [{"family": "Michielsen", "given": "Kristien", "initials": "K"}, {"family": "Larrson", "given": "Elin C", "initials": "EC"}, {"family": "K\u00e5gesten", "given": "Anna", "initials": "A"}, {"family": "Erausquin", "given": "Jennifer Toller", "initials": "JT"}, {"family": "Griffin", "given": "Sally", "initials": "S"}, {"family": "Van de Velde", "given": "Sarah", "initials": "S"}, {"family": "Tucker", "given": "Joseph D", "initials": "JD"}, {"family": "I-SHARE Team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-10-20", "journal": {"title": "Sex Transm Infect", "issn": "1472-3263", "volume": null, "issue": null, "issn-l": "1368-4973"}, "abstract": "COVID-19 may have a profound impact on sexual health, reproductive health and social life across the world. Shelter in place regulations that have extended across the globe may influence condomless sex, exacerbate intimate partner violence and reduce access to essential reproductive health services. Population representative research is challenging during shelter in place, leaving major gaps in our understanding of sexual and reproductive health during COVID-19. This International Sexual Health And ReproductivE health (I-SHARE) study protocol manuscript describes a common plan for online national surveys and global comparative analyses.\n\nThe purpose of this cross-sectional study is to better understand sexual and reproductive health in selected countries during the COVID-19 pandemic and facilitate multinational comparisons. Participants will be recruited through an online survey link disseminated through local, regional and national networks. In each country, a lead organisation will be responsible for organising ethical review, translation and survey administration. The consortium network provides support for national studies, coordination and multinational comparison. We will use multilevel modelling to determine the relationship between COVID-19 and condomless sex, intimate partner violence, access to reproductive health services, HIV testing and other key items. This study protocol defines primary outcomes, prespecified subanalyses and analysis plans.\n\nThe I-SHARE study examines sexual and reproductive health at the national and global level during the COVID-19 pandemic. We will use multilevel modelling to investigate country-level variables associated with outcomes of interest. This will provide a foundation for subsequent online multicountry comparison using more robust sampling methodologies.", "doi": "10.1136/sextrans-2020-054664", "pmid": "33082232", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "sextrans-2020-054664"}], "notes": [], "created": "2020-11-26T12:36:06.646Z", "modified": "2020-12-01T15:41:25.096Z"}, {"entity": "publication", "iuid": "3770f7604a374d3992aa913a910ac25d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3770f7604a374d3992aa913a910ac25d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3770f7604a374d3992aa913a910ac25d"}}, "title": "COVID-19 outbreak-related psychological distress among healthcare trainees: a cross-sectional study in China.", "authors": [{"family": "Wang", "given": "Yue", "initials": "Y"}, {"family": "Li", "given": "Yuchen", "initials": "Y"}, {"family": "Jiang", "given": "Jingwen", "initials": "J"}, {"family": "Feng", "given": "Yuying", "initials": "Y"}, {"family": "Lu", "given": "Donghao", "initials": "D"}, {"family": "Zhang", "given": "Wei", "initials": "W"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "journal article", "published": "2020-10-20", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "10", "issue": "10", "pages": "e041671"}, "abstract": "The COVID-19 outbreak has caused enormous strain on healthcare systems, and healthcare trainees, which comprise the future healthcare workforce, may be a vulnerable group. It is essential to assess the psychological distress experienced by healthcare trainees during the COVID-19 outbreak.\r\n\r\nA cross-sectional study with 4184 healthcare trainees at Sichuan University in China was implemented during 7-13 February 2020. Participants were grouped by training programmes (medicine, medical technology and nursing) and training stages (undergraduate, postgraduate and residency).\r\n\r\nCOVID-19-related psychological distress and acute stress reaction (ASR) were assessed using the Kessler 6-item Psychological Distress Scale and the Impact of Event Scale-Revised, respectively. We estimated the ORs of distress by comparing trainees across programmes and training stages using multivariable logistic regression.\r\n\r\nSignificant psychological distress was found in 1150 (30.90%) participants and probable ASR in 403 (10.74%). Compared with the nursing trainees, the medical trainees (OR 1.54, 95% CI 1.22 to 1.95) reported a higher burden of psychological distress during the outbreak, while the medical technology trainees (OR 1.25, 95% CI 0.97 to 1.62) reported similar symptom scores. Postgraduates (OR 1.55, 95% CI 1.16 to 2.08) in medicine had higher levels of distress than their undergraduate counterparts did, whereas the nursing residents (OR 0.38, 95% CI 0.20 to 0.71) reported a lower burden than did nursing undergraduates. A positive association was found between having active clinical duties during the outbreak and distress (OR 1.17, 95% CI 0.98 to 1.39), particularly among the medical trainees (OR 1.85, 95% CI 1.47 to 2.33) and undergraduates (OR 4.20, 95% CI 1.61 to 11.70). No clear risk patterns of ASR symptoms were observed.\r\n\r\nMedical trainees, particularly postgraduates and those with active clinical duties, were at risk for psychological distress during the COVID-19 outbreak. Stress management may be considered for high-risk healthcare trainees.", "doi": "10.1136/bmjopen-2020-041671", "pmid": "33082197", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-041671"}, {"db": "pmc", "key": "PMC7577057"}], "notes": [], "created": "2020-12-01T15:42:02.339Z", "modified": "2022-11-09T08:45:01.712Z"}, {"entity": "publication", "iuid": "9184c2b13df3405285a42ea6ea4c942a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9184c2b13df3405285a42ea6ea4c942a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9184c2b13df3405285a42ea6ea4c942a"}}, "title": "Refugees in Sweden During the Covid-19 Pandemic-The Need for a New Perspective on Health and Integration.", "authors": [{"family": "Elisabeth", "given": "Mangrio", "initials": "M"}, {"family": "Maneesh", "given": "Paul-Satyaseela", "initials": "PS"}, {"family": "Michael", "given": "Strange", "initials": "S"}], "type": "journal article", "published": "2020-10-19", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "574334", "issn-l": "2296-2565"}, "abstract": "Refugees are already a vulnerable group in society and are in a stressful situation due to their often uncertain legal status in seeking asylum and integration in the new society after migration. Refugees are, in general, at greater risk of poor health outcomes when contracting Covid-19, exacerbated by poor living conditions and difficulties in accessing healthcare. The longer-term social consequences of the pandemic also disproportionately impact refugees, including social isolation, unemployment, and difficulties to obtain correct health information. The aim of this paper is to review the social and health consequences that Covid-19 has brought to the refugees residing in Sweden. This needs to be emphasized in order to mitigate against these likely consequences and improve the overall well-being among such a highly vulnerable group in society. As Covid-19 demonstrates, human health needs to be understood holistically, meaning that the vulnerability of any individuals, or even nations, is a vulnerability for the whole population requiring urgent action.", "doi": "10.3389/fpubh.2020.574334", "pmid": "33194974", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7604301"}], "notes": [], "created": "2020-11-27T11:01:13.351Z", "modified": "2023-01-13T13:52:25.482Z"}, {"entity": "publication", "iuid": "9aed2029c548476eae887740c14ca236", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9aed2029c548476eae887740c14ca236.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9aed2029c548476eae887740c14ca236"}}, "title": "Management of patients with chronic rhinosinusitis during the COVID-19 pandemic - An EAACI Position Paper.", "authors": [{"family": "Klimek", "given": "L", "initials": "L"}, {"family": "Jutel", "given": "M", "initials": "M"}, {"family": "Bousquet", "given": "J", "initials": "J"}, {"family": "Agache", "given": "I", "initials": "I"}, {"family": "Akdis", "given": "C", "initials": "C"}, {"family": "Hox", "given": "V", "initials": "V"}, {"family": "Gevaert", "given": "P", "initials": "P"}, {"family": "Tomazic", "given": "P V", "initials": "PV"}, {"family": "Rondon", "given": "C", "initials": "C"}, {"family": "Cingi", "given": "C", "initials": "C"}, {"family": "Toppila-Salmi", "given": "S", "initials": "S"}, {"family": "Karavelia", "given": "A", "initials": "A"}, {"family": "Bozkurt", "given": "B", "initials": "B"}, {"family": "F\u00f6rster-Ruhrmann", "given": "U", "initials": "U"}, {"family": "Becker", "given": "S", "initials": "S"}, {"family": "Chaker", "given": "A M", "initials": "AM"}, {"family": "Wollenberg", "given": "B", "initials": "B"}, {"family": "M\u00f6sges", "given": "R", "initials": "R"}, {"family": "Huppertz", "given": "T", "initials": "T"}, {"family": "Hagemann", "given": "J", "initials": "J"}, {"family": "Bachert", "given": "C", "initials": "C"}, {"family": "Fokkens", "given": "W", "initials": "W"}], "type": "journal article", "published": "2020-10-19", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": null, "issue": null, "issn-l": "0105-4538"}, "abstract": "CRS is regarded as a chronic airway disease. According to WHO recommendations, it may be a risk factor for COVID-19 patients. In most CRSwNP cases, the inflammatory changes affecting the nasal and paranasal mucous membranes are type-2 (T2) inflammation endotypes.\n\nThe current knowledge on COVID-19 and on treatment options for CRS was analyzed by a literature search in Medline, Pubmed, international guidelines, the Cochrane Library and the Internet.\n\nBased on international literature, on current recommendations by WHO and other international organizations as well as on previous experience, a panel of experts from EAACI and ARIA provided recommendations for the treatment of CRS during the COVID-19 pandemic.\n\nIntranasal corticosteroids remain the standard treatment for CRS in patients with SARS-CoV-2 infection. Surgical treatments should be reduced to a minimum and surgery preserved for patients with local complications and for those with no other treatment options. Systemic corticosteroids should be avoided. Treatment with biologics can be continued with careful monitoring in non-infected patients and should be temporarily interrupted during the course of the COVID-19 infection.", "doi": "10.1111/all.14629", "pmid": "33075144", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-01T16:58:38.839Z", "modified": "2020-12-01T16:58:38.850Z"}, {"entity": "publication", "iuid": "05886c693526485f80fe8f4503151ef0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/05886c693526485f80fe8f4503151ef0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/05886c693526485f80fe8f4503151ef0"}}, "title": "Effect of COVID-19 pandemic on treatment of Type 1 diabetes in children.", "authors": [{"family": "Ludvigsson", "given": "Johnny", "initials": "J"}], "type": "journal article", "published": "2020-10-19", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": null, "issue": null, "pages": null}, "abstract": "Brief report", "doi": "10.1111/apa.15627", "pmid": "33073367", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-01T16:59:59.808Z", "modified": "2020-12-01T17:00:40.121Z"}, {"entity": "publication", "iuid": "70d4934c27434293805e8ae5fb7722b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70d4934c27434293805e8ae5fb7722b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70d4934c27434293805e8ae5fb7722b4"}}, "title": "Antibody responses to SARS-CoV-2 train machine learning to assign likelihood of past infection during virus emergence in Sweden", "authors": [{"family": "Castro Dopico", "given": "Xaqu\u00edn", "initials": "X"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Sheward", "given": "Daniel J.", "initials": "DJ"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Christian", "given": "Murray", "initials": "M"}, {"family": "Grinberg", "given": "Nastasiya F.", "initials": "NF"}, {"family": "Adori", "given": "Monika", "initials": "M"}, {"family": "Perez Vidakovics", "given": "Laura", "initials": "L"}, {"family": "Kim", "given": "ChangIl", "initials": "C"}, {"family": "Khoenkhoen", "given": "Sharesta", "initials": "S"}, {"family": "Pushparaj", "given": "Pradeepa", "initials": "P"}, {"family": "Moliner Morro", "given": "Ainhoa", "initials": "A"}, {"family": "Mandolesi", "given": "Marco", "initials": "M"}, {"family": "Ahl", "given": "Marcus", "initials": "M"}, {"family": "Forsell", "given": "Mattias", "initials": "M"}, {"family": "Coquet", "given": "Jonathan", "initials": "J"}, {"family": "Corcoran", "given": "Martin", "initials": "M"}, {"family": "Rorbach", "given": "Joanna", "initials": "J"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Allander", "given": "Tobias", "initials": "T"}, {"family": "Wallace", "given": "Chris", "initials": "C"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Karlsson Hedestam", "given": "Gunilla B.", "initials": "GB"}], "type": "posted-content", "published": "2020-10-19", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Serology is critical for understanding pathogen-specific immune responses, but is fraught with difficulty, not least because the strength of antibody (Ab) response varies greatly between individuals and mild infections generally generate lower Ab titers (1-3). We used robust IgM, IgG and IgA Ab tests to evaluate anti-SARS-CoV-2 responses in individuals PCR+ for virus RNA (n=105) representing different categories of disease severity, including mild cases. All PCR+ individuals in the study became IgG-positive against pre-fusion trimers of the virus spike (S) glycoprotein, but titers varied greatly. Elevated IgA, IL-6 and neutralizing responses were present in intensive care patients. Additionally, blood donors and pregnant women (n=2,900) sampled throughout the first wave of the pandemic in Stockholm, Sweden, further demonstrated that anti-S IgG titers differed several orders of magnitude between individuals, with an increase of low titer values present in the population at later time points (4,5). To improve upon current methods to identify low titers and extend the utility of individual measures (6,7), we used our PCR+ individual data to train machine learning algorithms to assign likelihood of past infection. Using these tools that assigned probability to individual responses against S and the receptor binding domain (RBD), we report SARS-CoV-2-specific IgG in 13.7% of healthy donors five months after the peak of spring COVID-19 deaths, when mortality and ICU occupancy in the country due to the virus were at low levels. These data further our understanding of antibody responses to the virus and provide solutions to problems in serology data analysis.", "doi": "10.1101/2020.07.17.20155937", "pmid": null, "labels": {"Type: Preprint": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://github.com/MurrellGroup/DiscriminativeSeroprevalence/", "description": "Inferring seroprevalence from ELISA data, without choosing a cutoff"}], "notes": [], "created": "2020-10-30T11:57:22.549Z", "modified": "2021-02-26T08:45:48.314Z"}, {"entity": "publication", "iuid": "925bb496b0f3481989389b307f005704", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/925bb496b0f3481989389b307f005704.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/925bb496b0f3481989389b307f005704"}}, "title": "Food Sovereignty of the Indigenous Peoples in the Arctic Zone of Western Siberia: Response to COVID-19 Pandemic.", "authors": [{"family": "Bogdanova", "given": "Elena", "initials": "E"}, {"family": "Andronov", "given": "Sergei", "initials": "S"}, {"family": "Morell", "given": "Ildiko Asztalos", "initials": "IA"}, {"family": "Hossain", "given": "Kamrul", "initials": "K"}, {"family": "Raheem", "given": "Dele", "initials": "D"}, {"family": "Filant", "given": "Praskovia", "initials": "P"}, {"family": "Lobanov", "given": "Andrey", "initials": "A"}], "type": "journal article", "published": "2020-10-18", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "20", "pages": null}, "abstract": "This article presents the challenges facing reindeer herding as being both a profitable business and part of the traditional culture of the nomadic Indigenous peoples in the Arctic zone of Western Siberia which addresses substantial needs of the local population. Reindeer herding products are used as traditional nutrition, and as effective preventive means and remedies for adapting to the cold and geomagnetic activity in the High North. Export trends of traditional reindeer products have decreased local Indigenous peoples' access to venison and had a negative impact on their health. Due to the COVID-19 pandemic, it is especially urgent for the Indigenous peoples to have sufficient access to traditional food and be involved in policy decision-making to maintain this traditional business. We aim to analyze the dependencies of Indigenous peoples on the reindeer produce-exporting \"food value chain\" and explore how (1) the independence of reindeer herders could be increased in these export chains and (2) how provision of their products to local communities could be secured. The study takes a multidisciplinary approach based on policy and socioeconomic analyses with input from medical research. Primary sources include data collected from interviews and surveys of Indigenous peoples during expeditions to the Nyda settlement, the Nydinskaya tundra, the Tazovsky settlement, the Tazovskaya tundra, the Nakhodka tundra, the Gyda and Gydansky settlements, the Yavai-Salinskaya tundra, the Seyakha settlement, the Seyakhinskaya and Tambeyskaya tundras located along the southern coast of the Ob Bay, the northeast coast of the Yamal Peninsula, the Tazovsky and Gydansky Peninsulas, and the Shuryshkarsky district. Data were collected during the summers and winters of 2014-2020.", "doi": "10.3390/ijerph17207570", "pmid": "33080982", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "ijerph17207570"}, {"db": "pmc", "key": "PMC7590208"}], "notes": [], "created": "2020-12-01T15:43:25.508Z", "modified": "2022-11-09T08:46:54.157Z"}, {"entity": "publication", "iuid": "267f1fcb0fb34478bf52e2fd9db96cd2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/267f1fcb0fb34478bf52e2fd9db96cd2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/267f1fcb0fb34478bf52e2fd9db96cd2"}}, "title": "Estimating total excess mortality during a COVID-19 outbreak in Stockholm, Sweden.", "authors": [{"family": "Pimenoff", "given": "Ville N", "initials": "VN"}, {"family": "Elfstr\u00f6m", "given": "Miriam", "initials": "M"}, {"family": "Baussano", "given": "Iacopo", "initials": "I"}, {"family": "Bj\u00f6rnstedt", "given": "Mikael", "initials": "M"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}], "type": "journal article", "published": "2020-10-18", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "issn-l": "1058-4838", "volume": null, "issue": null, "pages": null}, "abstract": "Total excess mortality peaked during a COVID19 outbreak in Stockholm, but 25% of these deaths were not recognized as Covid-19-related nor occurred in hospitals. Estimate of total excess mortality may give a more comprehensive picture of the total disease burden during a COVID19 outbreak, and may facilitate managing future outbreaks.", "doi": "10.1093/cid/ciaa1593", "pmid": "33070183", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "5929661"}, {"db": "pmc", "key": "PMC7665438"}], "notes": [], "created": "2020-11-18T16:48:58.988Z", "modified": "2021-02-26T08:45:47.953Z"}, {"entity": "publication", "iuid": "cfa37a55e8fc473d9a1938b3d880e236", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cfa37a55e8fc473d9a1938b3d880e236.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cfa37a55e8fc473d9a1938b3d880e236"}}, "title": "The COVID-19 pandemic and serious psychological consequences in Bangladesh: A population-based nationwide study.", "authors": [{"family": "Mamun", "given": "Mohammed A", "initials": "MA"}, {"family": "Sakib", "given": "Najmuj", "initials": "N"}, {"family": "Gozal", "given": "David", "initials": "D"}, {"family": "Bhuiyan", "given": "Akm Israfil", "initials": "AI"}, {"family": "Hossain", "given": "Sahadat", "initials": "S"}, {"family": "Bodrud-Doza", "given": "Md", "initials": "M"}, {"family": "Al Mamun", "given": "Firoj", "initials": "F"}, {"family": "Hosen", "given": "Ismail", "initials": "I"}, {"family": "Safiq", "given": "Mariam Binte", "initials": "MB"}, {"family": "Abdullah", "given": "Abu Hasnat", "initials": "AH"}, {"family": "Sarker", "given": "Md Abedin", "initials": "MA"}, {"family": "Rayhan", "given": "Istihak", "initials": "I"}, {"family": "Sikder", "given": "Md Tajuddin", "initials": "MT"}, {"family": "Muhit", "given": "Mohammad", "initials": "M"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2020-10-17", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "issn-l": null, "volume": "279", "issue": null, "pages": "462-472"}, "abstract": "As with other countries worldwide, lockdown measures during the COVID-19 outbreak in Bangladesh were sudden and unexpected, and have the capacity to elicit serious psychological consequences. The present study examined the psychological consequences of COVID-19 in Bangladesh during the lockdown period.\r\n\r\nA nationwide online cross-sectional survey study recruited 10,067 individuals covering all 64 districts in Bangladesh via social media (April 1-10, 2020). The survey comprised questions concerning socio-demographics, knowledge of COVID-19, behavior towards COVID-19, fear of COVID-19, insomnia, depression, and suicidal ideation. Logistic regression and structural equation modeling (SEM) analyses were performed to identify the risk factors depression and suicidal ideation. Geographical information system (GIS)-based spatial analysis was used to identify district-wise susceptibility to depression and suicidal ideation.\r\n\r\nThe prevalence rate of depression and suicidal ideation related to COVID-19 was 33% and 5%%. Common risk factors for suicidal ideation and depression included being young, being female, being a cigarette smoker, having comorbid diseases, having high scores on the Fear COVID-19 Scale, and having insomnia symptoms. GIS-based maps detected high depression and suicidal ideation in the capital of Bangladesh and the districts near the capital as well as coastal areas where COVID-19 prevalence was high, as compared with districts with no reported cases.\r\n\r\nSelf-reported scales and cross-sectional design of the study.\r\n\r\nCOVID-19 is associated with major psychological impact across Bangladesh, underlining the need of strategically located psychological support measures and improved access to mental health services, especially among women and younger people.", "doi": "10.1016/j.jad.2020.10.036", "pmid": "33120247", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0165-0327(20)32880-9"}, {"db": "pmc", "key": "PMC7568472"}], "notes": [], "created": "2020-12-01T15:09:02.752Z", "modified": "2022-11-09T08:48:33.526Z"}, {"entity": "publication", "iuid": "b550adb70b314df1a899f8f482650e72", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b550adb70b314df1a899f8f482650e72.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b550adb70b314df1a899f8f482650e72"}}, "title": "Rotational thromboelastometry results are associated with care level in COVID-19.", "authors": [{"family": "Almskog", "given": "Lou M", "initials": "LM"}, {"family": "Wikman", "given": "Agneta", "initials": "A"}, {"family": "Svensson", "given": "Jonas", "initials": "J"}, {"family": "Wanecek", "given": "Michael", "initials": "M"}, {"family": "Bottai", "given": "Matteo", "initials": "M"}, {"family": "van der Linden", "given": "Jan", "initials": "J"}, {"family": "\u00c5gren", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2020-10-17", "journal": {"title": "J Thromb Thrombolysis", "issn": "1573-742X", "volume": null, "issue": null, "issn-l": null}, "abstract": "High prevalence of thrombotic events in severely ill COVID-19 patients have been reported. Pulmonary embolism as well as microembolization of vital organs may in these individuals be direct causes of death. The identification of patients at high risk of developing thrombosis may lead to targeted, more effective prophylactic treatment. The primary aim of this study was to test whether rotational thromboelastometry (ROTEM) at admission indicates hypercoagulopathy and predicts the disease severity, assessed as care level, in COVID-19 patients. The study was designed as a prospective, observational study where COVID-19 patients over 18 years admitted to hospital were eligible for inclusion. Patients were divided into two groups depending on care level: (1) regular wards or (2) wards with specialized ventilation support. Conventional coagulation tests, blood type and ROTEM were taken at admission. 60 patients were included; age 61 (median), 67% men, many with comorbidities (e.g. hypertension, diabetes). The ROTEM variables Maximum Clot Firmness (EXTEM-/FIBTEM-MCF) were higher in COVID-19 patients compared with in healthy controls (p < 0.001) and higher in severely ill patients compared with in patients at regular wards (p < 0.05). Our results suggest that hypercoagulopathy is present early in patients with mild to moderate disease, and more pronounced in severe COVID-19 pneumonia. Non-O blood types were not overrepresented in COVID-19 positive patients. ROTEM variables showed hypercoagulopathy at admission and this pattern was more pronounced in patients with increased disease severity. If this feature is to be used to predict the risk of thromboembolic complications further studies are warranted.", "doi": "10.1007/s11239-020-02312-3", "pmid": "33068277", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.5878/wh80-0w17", "description": "Raw data"}], "notes": [], "created": "2020-12-01T17:06:38.593Z", "modified": "2021-02-26T08:45:48.601Z"}, {"entity": "publication", "iuid": "bd8661a4c7074ab29dc024d662305526", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bd8661a4c7074ab29dc024d662305526.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bd8661a4c7074ab29dc024d662305526"}}, "title": "Harmonization of antineutrophil cytoplasmic antibodies (ANCA) testing by reporting test result-specific likelihood ratios: position paper.", "authors": [{"family": "Bossuyt", "given": "Xavier", "initials": "X"}, {"family": "Damoiseaux", "given": "Jan", "initials": "J"}, {"family": "Rasmussen", "given": "Niels", "initials": "N"}, {"family": "van Paassen", "given": "Pieter", "initials": "P"}, {"family": "Hellmich", "given": "Bernard", "initials": "B"}, {"family": "Baslund", "given": "Bo", "initials": "B"}, {"family": "Blockmans", "given": "Daniel", "initials": "D"}, {"family": "Vermeersch", "given": "Pieter", "initials": "P"}, {"family": "Lopez-Hoyos", "given": "Marcos", "initials": "M"}, {"family": "Vercammen", "given": "Martine", "initials": "M"}, {"family": "Barret", "given": "Elisa", "initials": "E"}, {"family": "Hammar", "given": "Friederike", "initials": "F"}, {"family": "Leinfelder", "given": "Ulrich", "initials": "U"}, {"family": "Mahler", "given": "Michael", "initials": "M"}, {"family": "Olschowka", "given": "Nina", "initials": "N"}, {"family": "Roggenbuck", "given": "Dirk", "initials": "D"}, {"family": "Schlumberger", "given": "Wolfgang", "initials": "W"}, {"family": "Walker", "given": "Roger", "initials": "R"}, {"family": "R\u00f6nnelid", "given": "Johan", "initials": "J"}, {"family": "Cohen Tervaert", "given": "Jan-Willem", "initials": "JW"}, {"family": "Csernok", "given": "Elena", "initials": "E"}, {"family": "Fierz", "given": "Walter", "initials": "W"}, {"family": "for (i) the European Federation of Laboratory Medicine (EFLM) Task and Finish Group \u201cAutoimmunity Testing,\u201d (ii) the European Autoimmune Standardization Initiative (EASI) and the (iii) European Consensus Finding Study Group on autoantibodies (ECFSG)", "given": "", "initials": ""}], "type": "letter", "published": "2020-10-16", "journal": {"title": "Clin Chem Lab Med", "issn": "1437-4331", "volume": null, "issue": null, "issn-l": "1434-6621"}, "abstract": null, "doi": "10.1515/cclm-2020-1178", "pmid": "33027040", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "/j/cclm.ahead-of-print/cclm-2020-1178/cclm-2020-1178.xml"}], "notes": [], "created": "2020-11-19T19:46:53.265Z", "modified": "2021-02-26T08:46:13.472Z"}, {"entity": "publication", "iuid": "6bae92ff5cf94413903de7a063df791d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6bae92ff5cf94413903de7a063df791d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6bae92ff5cf94413903de7a063df791d"}}, "title": "Asthma and severe acute respiratory syndrome coronavirus 2019: current evidence and knowledge gaps.", "authors": [{"family": "Assaf", "given": "Sara M", "initials": "SM"}, {"family": "Tarasevych", "given": "Svitlana P", "initials": "SP"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}, {"family": "Hanania", "given": "Nicola A", "initials": "NA"}], "type": "journal article", "published": "2020-10-16", "journal": {"title": "Curr Opin Pulm Med", "issn": "1531-6971", "volume": null, "issue": null, "issn-l": "1070-5287"}, "abstract": "Although respiratory viruses are common triggers of asthma exacerbation, it is unknown whether this also applies to infection with SARS-CoV-2. Indeed, patients with asthma and allergy appear underrepresented in large reports of COVID-19 cases worldwide. In this review, we evaluate existing literature on this topic and potential underlying mechanisms for any interrelationship between asthma and COVID-19.\n\nData from several preclinical and clinical reports suggest a lower susceptibility for COVID-19 in patients with underlying type 2 airway inflammation including asthma that may be related to a reduced expression of ACE2 and TMPRSS2 receptors for SARS-CoV-2. Corticosteroids further decrease expression of the ACE2 and TMPRSS2 receptors, hence may also have a protective effect against infection with SARS-CoV-2. In addition, some studies suggest that the reported improvement in asthma control and a reduction in asthma exacerbations during the COVID-19 pandemic may be related to improvement in adherence to controller therapy and reduced exposure to triggers, such as other respiratory viruses and air pollutants. Recent data point towards differential susceptibility for COVID-19 among asthma patients based on their phenotype and/or endotype. On the basis of existing evidence, continuation with controller therapies is recommended for all patients with asthma. For patients with severe uncontrolled asthma infected by SARS-CoV-2, adjustment of controllers and biologics should be based on a multidisciplinary decision.\n\nUnderrepresentation of SARS-CoV-2-infected patients with asthma and related allergic diseases may be based on potentially protective underlying mechanisms, such as type 2 airway inflammation, downregulation of ACE2/TMPRSS2 receptors, reduced exposures to triggers and improved adherence to controller medications. Although it is imperative that control should be maintained and asthma medications be continued in all patients, management of patients with severe uncontrolled asthma infected by SARS-CoV-2 including adjustment of controllers and biologics should be discussed on an individual basis.", "doi": "10.1097/MCP.0000000000000744", "pmid": "33065601", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-27T11:51:37.680Z", "modified": "2020-11-27T12:38:55.348Z"}, {"entity": "publication", "iuid": "6854c632851b4cf8a636d73aa8c35e0f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6854c632851b4cf8a636d73aa8c35e0f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6854c632851b4cf8a636d73aa8c35e0f"}}, "title": "The Impact of the German Strategy for Containment of Coronavirus SARS-CoV-2 on Training Characteristics, Physical Activity and Sleep of Highly Trained Kayakers and Canoeists: A Retrospective Observational Study.", "authors": [{"family": "Zinner", "given": "Christoph", "initials": "C"}, {"family": "Matzka", "given": "Manuel", "initials": "M"}, {"family": "Leppich", "given": "Robert", "initials": "R"}, {"family": "Kounev", "given": "Samuel", "initials": "S"}, {"family": "Holmberg", "given": "Hans-Christer", "initials": "HC"}, {"family": "Sperlich", "given": "Billy", "initials": "B"}], "type": "journal article", "published": "2020-10-15", "journal": {"title": "Front Sports Act Living", "issn": "2624-9367", "volume": "2", "issue": null, "pages": "579830", "issn-l": null}, "abstract": "Aim: To characterize the impact of the German strategy for containment of Coronavirus SARS-CoV-2 (social distancing and lockdown) on the training, other habitual physical activity, and sleep in highly trained kayakers and canoeists. Method: During the 4 weeks immediately prior to and following the beginning of the German government's strategy for containment of Coronavirus SARS-CoV-2 on March 23, 2020, 14 highly trained athletes (VO2peak: 3,162 \u00b1 774 ml/min; 500-m best time: 117.9 \u00b1 7.9 s) wore a multi-sensor smartwatch to allow continuous assessment of heart rate, physical activity, and sleep duration. Result: In comparison to before lockdown, the overall weekly training time and the average length of each session of training during the lockdown decreased by 27.6% (P = 0.02; d = 0.91) and 15.4% (P = 0.36; d = 0.36), respectively. At the same time, the number of sessions involving specific (i.e., canoeing and kayaking) and non-specific (i.e., running, cycling) training, respectively, did not change (P = 0.36-0.37; d = 0.34-0.35). The number of sessions involving strength (+17.4%; P = 0.03; d = 0.89) or other types of training (+16.7%; P = 0.06; d = 0.75) increased during the lockdown with 2.8-17.5% more training time involving a heart rate <60%, 82-88, 89-93, or 94-100% of individual peak heart rate (HRpeak) (P = 0.03-0.86; d = 0.07-1.38), and 4.3-18.7% less time with a heart rate of 60-72 or 73-83% HRpeak (P = < 0.001-0.0.26; d = 0.44-2.24). The daily duration of sleep was ~30 min (6.7%) longer during the lockdown (P < 0.001; d = 1.53) and the overall time spent lying down was 17% greater (P < 0.001; d = 2.26); whereas sitting time (-9.4%; P = 0.003; d = 1.23), the duration of light (15 min; -7.3%; P = 0.04; d = 0.83), and moderate (-18.6%; P = 0.01; d = 1.00) physical activity other than training (-9.4%; P = 0.22; d = 0.00) were all lower during lockdown. Conclusion: The present data revealed that following the German lockdown for containment of the Coronavirus SARS-CoV-2, highly trained kayakers and canoeists spent less overall time training each week (-27.6%) with, on average, shorter training sessions (-15.1%) and less light-to-moderate physical activity outside of training. Moreover, they performed more strength training sessions per week, and all engaged in more training at intensities >82 and <60% of HRpeak and spent longer periods lying down and sleeping during the lockdown.", "doi": "10.3389/fspor.2020.579830", "pmid": "33345147", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7739795"}], "notes": [], "created": "2021-01-07T13:29:20.028Z", "modified": "2023-06-19T14:55:02.352Z"}, {"entity": "publication", "iuid": "adafb3508b7648b9860b5e515ac65d25", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/adafb3508b7648b9860b5e515ac65d25.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/adafb3508b7648b9860b5e515ac65d25"}}, "title": "Satellite-detected tropospheric nitrogen dioxide and spread of SARS-CoV-2 infection in Northern Italy.", "authors": [{"family": "Filippini", "given": "Tommaso", "initials": "T"}, {"family": "Rothman", "given": "Kenneth J", "initials": "KJ"}, {"family": "Goffi", "given": "Alessia", "initials": "A"}, {"family": "Ferrari", "given": "Fabrizio", "initials": "F"}, {"family": "Maffeis", "given": "Giuseppe", "initials": "G"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}, {"family": "Vinceti", "given": "Marco", "initials": "M"}], "type": "journal article", "published": "2020-10-15", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "volume": "739", "issue": null, "pages": "140278", "issn-l": "0048-9697"}, "abstract": "Following the outbreak of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) last December 2019 in China, Italy was the first European country to be severely affected, with the first local case diagnosed on 20 February 2020. The virus spread quickly, particularly in the North of Italy, with three regions (Lombardy, Veneto and Emilia-Romagna) being the most severely affected. These three regions accounted for >80% of SARS-CoV-2 positive cases when the tight lockdown was established (March 8). These regions include one of Europe's areas of heaviest air pollution, the Po valley. Air pollution has been recently proposed as a possible risk factor of SARS-CoV-2 infection, due to its adverse effect on immunity and to the possibility that polluted air may even carry the virus. We investigated the association between air pollution and subsequent spread of the SARS-CoV-2 infection within these regions. We collected NO 2 tropospheric levels using satellite data available at the European Space Agency before the lockdown. Using a multivariable restricted cubic spline regression model, we compared NO2 levels with SARS-CoV-2 infection prevalence rate at different time points after the lockdown, namely March 8, 22 and April 5, in the 28 provinces of Lombardy, Veneto and Emilia-Romagna. We found little association of NO2 levels with SARS-CoV-2 prevalence up to about 130 \u03bcmol/m2, while a positive association was evident at higher levels at each time point. Notwithstanding the limitations of the use of aggregated data, these findings lend some support to the hypothesis that high levels of air pollution may favor the spread of the SARS-CoV-2 infection.", "doi": "10.1016/j.scitotenv.2020.140278", "pmid": "32758963", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(20)33799-2"}, {"db": "pmc", "key": "PMC7297152"}], "notes": [], "created": "2020-12-07T15:43:31.840Z", "modified": "2020-12-07T15:43:31.851Z"}, {"entity": "publication", "iuid": "71feecb0597d4021a3035ca71bab259e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/71feecb0597d4021a3035ca71bab259e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/71feecb0597d4021a3035ca71bab259e"}}, "title": "SARS-CoV-2 (COVID-19) infection in pregnant women: characterization of symptoms and syndromes predictive of disease and severity through real-time, remote participatory epidemiology.", "authors": [{"family": "Molteni", "given": "Erika", "initials": "E", "orcid": "0000-0001-7773-8140", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9aed1fbe444b48d4bfacb12050953c8e.json"}}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Sudre", "given": "Carole H", "initials": "CH", "orcid": "0000-0001-5753-428X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c26472813fed4007a8757af771de1802.json"}}, {"family": "Magee", "given": "Laura A", "initials": "LA", "orcid": "0000-0002-1355-610X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ee8a639fe1c489887b631cec86a872d.json"}}, {"family": "Murray", "given": "Benjamin", "initials": "B"}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/34f34c0d3602439abe6096293c7c732d.json"}}, {"family": "Gomez", "given": "Maria F", "initials": "MF", "orcid": "0000-0001-6210-3142", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e09e37219c4f42c8a7b3a982da523859.json"}}, {"family": "Tsereteli", "given": "Neli", "initials": "N"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Brownstein", "given": "John S", "initials": "JS", "orcid": "0000-0001-8568-5317", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2be459b61ae457e8fdcef38a0bc4cf7.json"}}, {"family": "Davies", "given": "Richard", "initials": "R"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29401112ffd249b7b04fd9ae12e19241.json"}}, {"family": "Ourselin", "given": "Sebastien", "initials": "S", "orcid": "0000-0002-5694-5340", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74c7b9b1633144879042d198c7205656.json"}}, {"family": "Steves", "given": "Claire J", "initials": "CJ", "orcid": "0000-0002-4910-0489", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a17b6e5fd547400e82ca8f1e623dce39.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "Modat", "given": "Marc", "initials": "M", "orcid": "0000-0002-5277-8530", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/794a8484b16a4a42a35c505688018eb1.json"}}], "type": "preprint", "published": "2020-10-14", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To test whether pregnant and non-pregnant women differ in COVID-19 symptom profile and severity. To extend previous investigations on hospitalized pregnant women to those who did not require hospitalization.\n\nObservational study prospectively collecting longitudinal (smartphone application interface) and cross-sectional (web-based survey) data.\n\nCommunity-based self-participatory citizen surveillance in the United Kingdom, Sweden and the United States of America.\n\nTwo female community-based cohorts aged 18-44 years. The discovery cohort was drawn from 1,170,315 UK, Sweden and USA women (79 pregnant tested positive) who self-reported status and symptoms longitudinally via smartphone. The replication cohort included 1,344,966 USA women (134 pregnant tested positive) who provided cross-sectional self-reports.\n\nPregnant and non-pregnant were compared for frequencies of symptoms and events, including SARS-CoV-2 testing and hospitalization rates. Multivariable regression was used to investigate symptoms severity and comorbidity effects.\n\nPregnant and non-pregnant women positive for SARS-CoV-2 infection were not different in syndromic severity. Pregnant were more likely to have received testing than non-pregnant, despite reporting fewer symptoms. Pre-existing lung disease was most closely associated with the syndromic severity in pregnant hospitalized women. Heart and kidney diseases and diabetes increased risk. The most frequent symptoms among all non-hospitalized women were anosmia [63% pregnant, 92% non-pregnant] and headache [72%, 62%]. Cardiopulmonary symptoms, including persistent cough [80%] and chest pain [73%], were more frequent among pregnant women who were hospitalized.\n\nSymptom characteristics and severity were comparable among pregnant and non-pregnant women, except for gastrointestinal symptoms. Consistent with observations in non-pregnant populations, lung disease and diabetes were associated with increased risk of more severe SARS-CoV-2 infection during pregnancy.", "doi": "10.1101/2020.08.17.20161760", "pmid": "32839787", "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7444306"}, {"db": "pii", "key": "2020.08.17.20161760"}], "notes": [], "created": "2020-12-07T10:29:38.783Z", "modified": "2023-06-19T15:08:12.850Z"}, {"entity": "publication", "iuid": "921293bc4dd94ced8c6db449251f6eae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/921293bc4dd94ced8c6db449251f6eae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/921293bc4dd94ced8c6db449251f6eae"}}, "title": "Rethinking developed nations' health systems through a social sustainability perspective in the light of the COVID-19 pandemic. A viewpoint.", "authors": [{"family": "Macassa", "given": "Gloria", "initials": "G"}, {"family": "Tomaselli", "given": "Gianpaolo", "initials": "G"}], "type": "journal article", "published": "2020-10-14", "journal": {"title": "J Public Health Res", "issn": "2279-9028", "volume": "9", "issue": "4", "pages": "1834", "issn-l": null}, "abstract": "This viewpoint paper argues for the need for more socially sustainable care systems that can better contribute to equitable utilization of health care in a post-pandemic era. Health care systems in developed nations need to rethink their role, particularly with regard to the achievement of Sustainable Development Goal 3 (SDG 3) as well as becoming more sustainable societies. Socially sustainable care systems will recognize that systemic factors and processes (social, economic, environmental, cultural) need to be addressed simultaneously in order to achieve health equity. Moreover, these systems are likely to be of paramount importance for post-COVID-19, because of the potential increase in demand for health care due to forgone health care and the increased burden of chronic diseases as spillover effects related to COVID-19 mitigation interventions.", "doi": "10.4081/jphr.2020.1834", "pmid": "33209860", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7649672"}], "notes": [], "created": "2020-11-30T16:11:49.861Z", "modified": "2020-11-30T16:11:49.885Z"}, {"entity": "publication", "iuid": "e8e888fa0a634256b20d6587ef48b94c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e8e888fa0a634256b20d6587ef48b94c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e8e888fa0a634256b20d6587ef48b94c"}}, "title": "Global impact of COVID-19 on non-communicable disease management: descriptive analysis of access to FRAX fracture risk online tool for prevention of osteoporotic fractures.", "authors": [{"family": "McCloskey", "given": "E V", "initials": "EV"}, {"family": "Harvey", "given": "N C", "initials": "NC"}, {"family": "Johansson", "given": "H", "initials": "H"}, {"family": "Lorentzon", "given": "M", "initials": "M"}, {"family": "Vandenput", "given": "L", "initials": "L"}, {"family": "Liu", "given": "E", "initials": "E"}, {"family": "Kanis", "given": "J A", "initials": "JA"}], "type": "journal article", "published": "2020-10-14", "journal": {"title": "Osteoporos Int", "issn": "1433-2965", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic, and its management, is markedly impacting the management of osteoporosis as judged by access to online FRAX fracture risk assessments. Globally, access was 58% lower in April than in February 2020. Strategies to improve osteoporosis care, with greater use of fracture risk assessments, offer a partial solution.\r\n\r\nThe COVID-19 pandemic is having a significant detrimental impact on the management of chronic diseases including osteoporosis. We have quantified the global impact by examining changes in the usage of online FRAX fracture risk assessments before and after the declaration of the pandemic (11 March 2020).\r\n\r\nThe study comprised a retrospective analysis using GoogleAnalytics data on daily sessions on the FRAX\u00ae website ( www.sheffield.ac.uk/FRAX ) from November 2019 to April 2020 (main analysis period February-April 2020), and the geographical source of that activity.\r\n\r\nOver February-April 2020, the FRAX website recorded 460,495 sessions from 184 countries, with 210,656 sessions in February alone. In March and April, the number of sessions fell by 23.1% and 58.3% respectively, a pattern not observed over the same period in 2019. There were smaller reductions in Asia than elsewhere, partly related to earlier and less-marked nadirs in some countries (China, Taiwan, Hong Kong, South Korea and Vietnam). In Europe, the majority of countries (24/31, 77.4%) reduced usage by at least 50% in April. Seven countries showed smaller reductions (range - 2.85 to - 44.1%) including Poland, Slovakia, Czech Republic, Germany, Norway, Sweden and Finland. There was no significant relationship between the reduction in FRAX usage and measures of disease burden such as COVID-attributed deaths per million of the population.\r\n\r\nThis study documents a marked global impact of the COVID-19 pandemic on the management of osteoporosis as reflected by FRAX online fracture risk assessments. The analysis suggests that impact may relate to the societal and healthcare measures taken to ameliorate the pandemic.", "doi": "10.1007/s00198-020-05542-6", "pmid": "33057738", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00198-020-05542-6"}, {"db": "pmc", "key": "PMC7556595"}], "notes": [], "created": "2020-12-01T17:11:07.268Z", "modified": "2022-11-09T08:54:18.900Z"}, {"entity": "publication", "iuid": "56017c8d0b4a4351a6f0654886292ba0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56017c8d0b4a4351a6f0654886292ba0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56017c8d0b4a4351a6f0654886292ba0"}}, "title": "Benchmarking virus concentration methods for quantification of SARS-CoV-2 in raw wastewater", "authors": [{"family": "Jafferali", "given": "Mohammed Hakim", "initials": "MH"}, {"family": "Khatami", "given": "Kasra", "initials": "K"}, {"family": "Atasoy", "given": "Merve", "initials": "M"}, {"family": "Birgersson", "given": "Madeleine", "initials": "M"}, {"family": "Williams", "given": "Cecilia", "initials": "C"}, {"family": "Cetecioglu", "given": "Zeynep", "initials": "Z"}], "type": "journal-article", "published": "2020-10-14", "journal": {"title": "Science of The Total Environment", "issn": "0048-9697", "issn-l": "0048-9697", "volume": "755", "issue": "Pt 1", "pages": "142939"}, "abstract": "Wastewater-based epidemiology offers a cost-effective alternative to testing large populations for SARS-CoV-2 virus, and may potentially be used as an early warning system for SARS-CoV-2 pandemic spread. However, viruses are highly diluted in wastewater, and a validated method for their concentration and further processing, and suitable reference viruses, are the main needs to be established for reliable SARS-CoV-2 municipal wastewater detection. For this purpose, we collected wastewater from two European cities during the Covid-19 pandemic and evaluated the sensitivity of RT-qPCR detection of viral RNA after four concentration methods (two variants of ultrafiltration-based method and two adsorption and extraction-based methods). Further, we evaluated one external (bovine corona virus) and one internal (pepper mild mottle virus) reference virus. We found a consistently higher recovery of spiked virus using the modified ultrafiltration-based method. This method also had a significantly higher efficiency (p-value <0.01) for wastewater SARS-CoV-2 detection. The ultracentrifugation method was the only method that detected SARS-CoV-2 in the wastewater of both cities. The pepper mild mottle virus was found to function as a potentially suitable internal reference standard.", "doi": "10.1016/j.scitotenv.2020.142939", "pmid": "33121776", "labels": {"Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Funder: VR": null, "Research Area: Environmental virus profiling": null}, "xrefs": [], "notes": [], "created": "2020-11-04T16:24:02.607Z", "modified": "2021-06-13T14:20:47.780Z"}, {"entity": "publication", "iuid": "11fc0facc2b6421f9c19355255e2c2a1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/11fc0facc2b6421f9c19355255e2c2a1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/11fc0facc2b6421f9c19355255e2c2a1"}}, "title": "A materials-science perspective on tackling COVID-19.", "authors": [{"family": "Tang", "given": "Zhongmin", "initials": "Z", "orcid": "0000-0002-1532-8004", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/75c277e0db294d1dbf4cf183b78392cd.json"}}, {"family": "Kong", "given": "Na", "initials": "N"}, {"family": "Zhang", "given": "Xingcai", "initials": "X", "orcid": "0000-0001-7114-1095", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c328b6119cf54f8589012b0add4f13ef.json"}}, {"family": "Liu", "given": "Yuan", "initials": "Y"}, {"family": "Hu", "given": "Ping", "initials": "P"}, {"family": "Mou", "given": "Shan", "initials": "S"}, {"family": "Liljestr\u00f6m", "given": "Peter", "initials": "P"}, {"family": "Shi", "given": "Jianlin", "initials": "J", "orcid": "0000-0001-8790-195X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9e484b2f7d5414585be457b42d13dba.json"}}, {"family": "Tan", "given": "Weihong", "initials": "W", "orcid": "0000-0002-8066-1524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bc983c96b5874c20adf7a7e8c5e511be.json"}}, {"family": "Kim", "given": "Jong Seung", "initials": "JS"}, {"family": "Cao", "given": "Yihai", "initials": "Y"}, {"family": "Langer", "given": "Robert", "initials": "R", "orcid": "0000-0003-4255-0492", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8ee4392159f340659f2e334c799dfd12.json"}}, {"family": "Leong", "given": "Kam W", "initials": "KW"}, {"family": "Farokhzad", "given": "Omid C", "initials": "OC"}, {"family": "Tao", "given": "Wei", "initials": "W", "orcid": "0000-0002-4277-3728", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b5ed1e15ddf44fe4bfc6ad8d5cd35379.json"}}], "type": "journal article", "published": "2020-10-14", "journal": {"title": "Nat Rev Mater", "issn": "2058-8437", "volume": "5", "issue": "11", "pages": "847-860", "issn-l": "2058-8437"}, "abstract": "The ongoing SARS-CoV-2 pandemic highlights the importance of materials science in providing tools and technologies for antiviral research and treatment development. In this Review, we discuss previous efforts in materials science in developing imaging systems and microfluidic devices for the in-depth and real-time investigation of viral structures and transmission, as well as material platforms for the detection of viruses and the delivery of antiviral drugs and vaccines. We highlight the contribution of materials science to the manufacturing of personal protective equipment and to the design of simple, accurate and low-cost virus-detection devices. We then investigate future possibilities of materials science in antiviral research and treatment development, examining the role of materials in antiviral-drug design, including the importance of synthetic material platforms for organoids and organs-on-a-chip, in drug delivery and vaccination, and for the production of medical equipment. Materials-science-based technologies not only contribute to the ongoing SARS-CoV-2 research efforts but can also provide platforms and tools for the understanding, protection, detection and treatment of future viral diseases.", "doi": "10.1038/s41578-020-00247-y", "pmid": "33078077", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7556605"}, {"db": "pii", "key": "247"}], "notes": [], "created": "2020-11-26T12:20:01.618Z", "modified": "2023-06-19T14:36:07.995Z"}, {"entity": "publication", "iuid": "782ddc32ba1b4bafaf233aaa77d0e0d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/782ddc32ba1b4bafaf233aaa77d0e0d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/782ddc32ba1b4bafaf233aaa77d0e0d5"}}, "title": "The COVID-19 pandemic: The importance of physical activity among faculty members.", "authors": [{"family": "Fr\u00f6berg", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2020-10-13", "journal": {"title": "J Am Coll Health", "issn": "1940-3208", "issn-l": null, "volume": null, "issue": null, "pages": "1-4"}, "abstract": "The novel coronavirus (SARS-CoV-2) disease 2019 (COVID-19) pandemic has posed serious challenge to societies worldwide. To prevent person-to-person transmission of the coronavirus and avoid associated morbidity and mortality, several public health measures have been introduced by various health organizations and authorities, such as social distancing policies and quarantine. While necessary, these public health measures are likely to have implications for people's physical activity behaviors. This viewpoint is intended for faculty members and focus on the importance of physical activity for health. Suggestions on how to stay physically active during the COVID-19 pandemic are also provided.", "doi": "10.1080/07448481.2020.1817037", "pmid": "33048633", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-01T17:12:20.056Z", "modified": "2022-11-09T08:55:35.729Z"}, {"entity": "publication", "iuid": "a99bb5289fde46d39c4ab2f27181521a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a99bb5289fde46d39c4ab2f27181521a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a99bb5289fde46d39c4ab2f27181521a"}}, "title": "Registry reports in COVID-19 patients: Juggling with big data, poor data, and no data.", "authors": [{"family": "S\u00f8fteland", "given": "John Mackay", "initials": "JM"}, {"family": "Karason", "given": "Kristjan", "initials": "K"}, {"family": "Magnusson", "given": "Jesper", "initials": "J"}, {"family": "Schult", "given": "Andreas", "initials": "A"}, {"family": "Felldin", "given": "Marie", "initials": "M"}, {"family": "Friman", "given": "Vanda", "initials": "V"}, {"family": "Oltean", "given": "Mihai", "initials": "M"}], "type": "letter", "published": "2020-10-13", "journal": {"title": "Kidney Int", "issn": "1523-1755", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/j.kint.2020.09.017", "pmid": "33065132", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0085-2538(20)31181-9"}, {"db": "pmc", "key": "PMC7550855"}], "notes": [], "created": "2020-12-01T17:08:55.634Z", "modified": "2020-12-01T17:08:55.656Z"}, {"entity": "publication", "iuid": "a49fb892a93344f393c58081203719f7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a49fb892a93344f393c58081203719f7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a49fb892a93344f393c58081203719f7"}}, "title": "Mass gathering events and undetected transmission of SARS-CoV-2 in vulnerable populations leading to an outbreak with high case fatality ratio in the district of Tirschenreuth, Germany.", "authors": [{"family": "Brandl", "given": "M", "initials": "M"}, {"family": "Selb", "given": "R", "initials": "R"}, {"family": "Seidl-Pillmeier", "given": "S", "initials": "S"}, {"family": "Marosevic", "given": "D", "initials": "D"}, {"family": "Buchholz", "given": "U", "initials": "U"}, {"family": "Rehmet", "given": "S", "initials": "S"}], "type": "journal article", "published": "2020-10-13", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": "148", "issue": null, "pages": "e252", "issn-l": null}, "abstract": "In early March 2020, a COVID-19-outbreak occurred in the district of Tirschenreuth, Germany. The outbreak was characterised by a rapid increase in case numbers and a comparatively high crude case fatality ratio (CFR; 11%). Until the beginning of May 2020, 1122 cases were reported in the district. To investigate the outbreak, we analysed surveillance and other data available at the district health department, including data on cases living in care facilities and public health measures applied. Furthermore, we compared the number of tests performed in Tirschenreuth and in Germany as a whole. We interviewed the first 110 cases in order to investigate potential exposures at the beginning of the outbreak. We found that returning ski-travellers from Austria and Italy and early undetected community transmission likely initiated the outbreak which was then accelerated by Bavarian beer festivities. Testing of mainly acute cases in the district of Tirschenreuth resulted in a higher rate of positive tests compared to the whole of Germany. Despite adjustment for age, the CFR continued to exceed the German mean which was due to spread to vulnerable populations. Strict public health measures likely contributed to control the outbreak by mid-April 2020.", "doi": "10.1017/S0950268820002460", "pmid": "33046173", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0950268820002460"}, {"db": "pmc", "key": "PMC7588716"}], "notes": [], "created": "2020-12-01T17:14:59.942Z", "modified": "2021-02-26T08:45:48.542Z"}, {"entity": "publication", "iuid": "c349b903a6a94f64b50936430c06a8d2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c349b903a6a94f64b50936430c06a8d2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c349b903a6a94f64b50936430c06a8d2"}}, "title": "Influenza Vaccination to Reduce Cardiovascular Morbidity and Mortality in Patients With COVID-19: JACC State-of-the-Art Review.", "authors": [{"family": "Behrouzi", "given": "Bahar", "initials": "B"}, {"family": "Araujo Campoverde", "given": "Maria Viviana", "initials": "MV"}, {"family": "Liang", "given": "Kyle", "initials": "K"}, {"family": "Talbot", "given": "H Keipp", "initials": "HK"}, {"family": "Bogoch", "given": "Isaac I", "initials": "II"}, {"family": "McGeer", "given": "Allison", "initials": "A"}, {"family": "Fr\u00f6bert", "given": "Ole", "initials": "O"}, {"family": "Loeb", "given": "Mark", "initials": "M"}, {"family": "Vardeny", "given": "Orly", "initials": "O"}, {"family": "Solomon", "given": "Scott D", "initials": "SD"}, {"family": "Udell", "given": "Jacob A", "initials": "JA"}], "type": "journal article", "published": "2020-10-13", "journal": {"title": "J Am Coll Cardiol", "issn": "1558-3597", "volume": "76", "issue": "15", "pages": "1777-1794", "issn-l": "0735-1097"}, "abstract": "Viral respiratory infections are risk factors for cardiovascular disease (CVD). Underlying CVD is also associated with an increased risk of complications following viral respiratory infections, including increased morbidity, mortality, and health care utilization. Globally, these phenomena are observed with seasonal influenza and with the current coronavirus disease 2019 (COVID-19) pandemic. Persons with CVD represent an important target population for respiratory virus vaccines, with capacity developed within 3 large ongoing influenza vaccine cardiovascular outcomes trials to determine the potential cardioprotective effects of influenza vaccines. In the context of COVID-19, these international trial networks may be uniquely positioned to redeploy infrastructure to study therapies for primary and secondary prevention of COVID-19. Here, we describe mechanistic links between influenza and COVID-19 infection and the risk of acute cardiovascular events, summarize the data to date on the potential cardioprotective effects of influenza vaccines, and describe the ongoing influenza vaccine cardiovascular outcomes trials, highlighting important lessons learned that are applicable to COVID-19.", "doi": "10.1016/j.jacc.2020.08.028", "pmid": "33032740", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0735-1097(20)36325-7"}, {"db": "pmc", "key": "PMC7535809"}], "notes": [], "created": "2020-11-27T12:38:57.742Z", "modified": "2020-11-27T12:38:57.764Z"}, {"entity": "publication", "iuid": "f71ffb963b69438bbc97e6ec3b99934a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f71ffb963b69438bbc97e6ec3b99934a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f71ffb963b69438bbc97e6ec3b99934a"}}, "title": "The Impact of the COVID-19 Pandemic on Surgical Management of Breast Cancer: Global Trends and Future Perspectives.", "authors": [{"family": "Rocco", "given": "Nicola", "initials": "N"}, {"family": "Montagna", "given": "Giacomo", "initials": "G"}, {"family": "Di Micco", "given": "Rosa", "initials": "R"}, {"family": "Benson", "given": "John", "initials": "J"}, {"family": "Criscitiello", "given": "Carmen", "initials": "C"}, {"family": "Chen", "given": "Li", "initials": "L"}, {"family": "Di Pace", "given": "Bruno", "initials": "B"}, {"family": "Esgueva Colmenarejo", "given": "Antonio Jesus", "initials": "AJ"}, {"family": "Harder", "given": "Yves", "initials": "Y"}, {"family": "Karakatsanis", "given": "Andreas", "initials": "A"}, {"family": "Maglia", "given": "Anna", "initials": "A"}, {"family": "Mele", "given": "Marco", "initials": "M"}, {"family": "Nafissi", "given": "Nahid", "initials": "N"}, {"family": "Ferreira", "given": "Pedro Santos", "initials": "PS"}, {"family": "Taher", "given": "Wafa", "initials": "W"}, {"family": "Tejerina", "given": "Antonio", "initials": "A"}, {"family": "Vinci", "given": "Alessio", "initials": "A"}, {"family": "Nava", "given": "Maurizio", "initials": "M"}, {"family": "Catanuto", "given": "Giuseppe", "initials": "G"}], "type": "journal article", "published": "2020-10-12", "journal": {"title": "Oncologist", "issn": "1549-490X", "volume": "26", "issue": "1", "pages": "e66-e77", "issn-l": null}, "abstract": "The rapid spread of COVID-19 across the globe is forcing surgical oncologists to change their daily practice. We sought to evaluate how breast surgeons are adapting their surgical activity to limit viral spread and spare hospital resources.\n\nA panel of 12 breast surgeons from the most affected regions of the world convened a virtual meeting on April 7, 2020, to discuss the changes in their local surgical practice during the COVID-19 pandemic. Similarly, a Web-based poll based was created to evaluate changes in surgical practice among breast surgeons from several countries.\n\nThe virtual meeting showed that distinct countries and regions were experiencing different phases of the pandemic. Surgical priority was given to patients with aggressive disease not candidate for primary systemic therapy, those with progressive disease under neoadjuvant systemic therapy, and patients who have finished neoadjuvant therapy. One hundred breast surgeons filled out the poll. The trend showed reductions in operating room schedules, indications for surgery, and consultations, with an increasingly restrictive approach to elective surgery with worsening of the pandemic.\n\nThe COVID-19 emergency should not compromise treatment of a potentially lethal disease such as breast cancer. Our results reveal that physicians are instinctively reluctant to abandon conventional standards of care when possible. However, as the situation deteriorates, alternative strategies of de-escalation are being adopted.\n\nThis study aimed to characterize how the COVID-19 pandemic is affecting breast cancer surgery and which strategies are being adopted to cope with the situation.", "doi": "10.1002/onco.13560", "pmid": "33044007", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7675306"}], "notes": [], "created": "2020-12-01T17:18:02.032Z", "modified": "2021-02-26T08:45:48.873Z"}, {"entity": "publication", "iuid": "3ea73e2997424ea4a5071572466b1f6f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ea73e2997424ea4a5071572466b1f6f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ea73e2997424ea4a5071572466b1f6f"}}, "title": "Cardiac Troponin Testing in Patients with COVID-19: A Strategy for Testing and Reporting Results.", "authors": [{"family": "Kavsak", "given": "Peter A", "initials": "PA"}, {"family": "Hammarsten", "given": "Ola", "initials": "O"}, {"family": "Worster", "given": "Andrew", "initials": "A"}, {"family": "Smith", "given": "Stephen W", "initials": "SW"}, {"family": "Apple", "given": "Fred S", "initials": "FS"}], "type": "journal article", "published": "2020-10-12", "journal": {"title": "Clin Chem", "issn": "1530-8561", "volume": "67", "issue": "1", "pages": "107-113", "issn-l": "0009-9147"}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged late in 2019 causing COVID-19 (coronavirus disease-2019) may adversely affect the cardiovascular system. Publications from Asia, Europe and North America have identified cardiac troponin as an important prognostic indicator for patients hospitalized with COVID-19. We recognized from publications within the first 6 months of the pandemic that there has been much uncertainty on the reporting, interpretation, and pathophysiology of an increased cardiac troponin concentration in this setting.\n\nThe purpose of this mini-review is: a) to review the pathophysiology of SARS-CoV-2 and the cardiovascular system, b) to overview the strengths and weaknesses of selected studies evaluating cardiac troponin in patients with COVID-19, and c) recommend testing strategies in the acute period, in the convalescence period and in long-term care for patients who have become ill with COVID-19.\n\nThis review provides important educational information and identifies gaps in understanding the role of cardiac troponin and COVID-19. Future, properly designed studies will hopefully provide the much-needed evidence on the path forward in testing cardiac troponin in patients with COVID-19.", "doi": "10.1093/clinchem/hvaa225", "pmid": "33045044", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "5921202"}, {"db": "pmc", "key": "PMC7665403"}], "notes": [], "created": "2020-11-27T12:38:56.488Z", "modified": "2021-01-22T09:27:06.802Z"}, {"entity": "publication", "iuid": "80775a0ee6f946ec9ea6ffe6c38eda01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/80775a0ee6f946ec9ea6ffe6c38eda01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/80775a0ee6f946ec9ea6ffe6c38eda01"}}, "title": "Minor covid-19 association with crime in Sweden.", "authors": [{"family": "Gerell", "given": "Manne", "initials": "M"}, {"family": "Kardell", "given": "Johan", "initials": "J"}, {"family": "Kindgren", "given": "Johanna", "initials": "J"}], "type": "journal article", "published": "2020-10-11", "journal": {"title": "Crime Sci", "issn": "2193-7680", "issn-l": null, "volume": "9", "issue": "1", "pages": "19"}, "abstract": "The covid-19 disease has a large impact on life across the globe, and this could potentially include impacts on crime. The present study describes how crime has changed in Sweden during ten weeks after the government started to implement interventions to reduce spread of the disease. Sweden has undertaken smaller interventions than many other countries and is therefore a particularly interesting case to study. The first major interventions in Sweden were implemented in the end of week 11 (March 12th) in the year 2020, and we analyze police reported crimes through week 21 (ending May 24th). Descriptive statistics are provided relative to expected levels with 95% confidence intervals for eight crime types. We find that total crime, assaults, pickpocketing and burglary have decreased significantly, personal robberies and narcotics crime are unchanged. Vandalism possibly increased somewhat but is hard to draw any firm conclusions on. The reductions are fairly small for most crime types, in the 5-20% range, with pickpocketing being the biggest exception noting a 59% drop relative to expected levels.", "doi": "10.1186/s40163-020-00128-3", "pmid": "33072489", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "128"}, {"db": "pmc", "key": "PMC7548025"}], "notes": [], "created": "2020-12-01T17:03:37.772Z", "modified": "2022-11-09T08:56:13.634Z"}, {"entity": "publication", "iuid": "82fea9198e95441299581781787cd5e8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82fea9198e95441299581781787cd5e8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82fea9198e95441299581781787cd5e8"}}, "title": "May Mangafodipir or Other SOD Mimetics Contribute to Better Care in COVID-19 Patients?", "authors": [{"family": "Karlsson", "given": "Jan Olof G", "initials": "JOG"}, {"family": "Jynge", "given": "Per", "initials": "P"}, {"family": "Ignarro", "given": "Louis J", "initials": "LJ"}], "type": "journal article", "published": "2020-10-10", "journal": {"title": "Antioxidants (Basel)", "issn": "2076-3921", "issn-l": "2076-3921", "volume": "9", "issue": "10", "pages": null}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by massive inflammation of the arterial endothelium accompanied by vasoconstriction and widespread pulmonary micro thrombi. As a result, due to the destruction of nitric oxide ( \u2022NO) by inflammatory superoxide (O2\u2022-), pulmonary \u2022NO concentration ceases, resulting in uncontrolled platelet aggregation and massive thrombosis, which kills the patients. Introducing \u2022NO by inhalation (INO) may replace the loss of endothelium-derived \u2022NO. The first results from clinical trials with INO in SARS-CoV-2 patients show a rapid and sustained improvement in cardiopulmonary function and decreased inflammation. An ongoing phase III study is expected to confirm the method's efficacy. INO may hence become a first line treatment in SARS-CoV-2 patients. However, due to the rapid inactivation of \u2022NO by deoxyhemoglobin to nitrate, pulmonary administration of \u2022NO will not protect remote organs. Another INO-related pharmacological approach to protect SARS-CoV-2 patients from developing life-threatening disease is to inhibit the O2\u2022--driven destruction of \u2022NO by neutralizing inflammatory O2\u2022-. By making use of low molecular weight compounds that mimic the action of the enzyme manganese superoxide dismutase (MnSOD). The MnSOD mimetics of the so-called porphyrin type (e.g., AEOL 10150), salen type (e.g., EUK-8) and cyclic polyamine type (e.g., M40419, today known as GC4419 and avasopasem manganese) have all been shown to positively affect the inflammatory response in lung epithelial cells in preclinical models of chronic obstructive pulmonary disease. The Manganese diPyridoxyL EthylDiamine (MnPLED)-type mangafodipir (manganese dipyridoxyl diphosphate-MnDPDP), a magnetic resonance imaging (MRI) contrast agent that possesses MnSOD mimetic activity, has shown promising results in various forms of inflammation, in preclinical as well as clinical settings. Intravenously administration of mangafodipir will, in contrast to INO, reach remote organs and may hence become an important supplement to INO. From the authors' viewpoint, it appears logical to test mangafodipr in COVID-19 patients at risk of developing life-threatening SARS-CoV-2. Five days after submission of the current manuscript, Galera Pharmaceuticals Inc. announced the dosing of the first patient in a randomized, double-blind pilot phase II clinical trial with GC4419 for COVID-19. The study was first posted on ClinicalTrials.gov (Identifier: NCT04555096) 18 September 2020.", "doi": "10.3390/antiox9100971", "pmid": "33050459", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "antiox9100971"}, {"db": "pmc", "key": "PMC7601469"}, {"db": "ClinicalTrials.gov", "key": "NCT04555096"}], "notes": [], "created": "2020-11-27T10:48:45.935Z", "modified": "2022-11-09T08:57:17.902Z"}, {"entity": "publication", "iuid": "ee9bb534c987464f94919f14262a802b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee9bb534c987464f94919f14262a802b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee9bb534c987464f94919f14262a802b"}}, "title": "A prediction model to prioritize individuals for SARS-CoV-2 test built from national symptom surveys.", "authors": [{"family": "Shoer", "given": "Saar", "initials": "S"}, {"family": "Karady", "given": "Tal", "initials": "T"}, {"family": "Keshet", "given": "Ayya", "initials": "A"}, {"family": "Shilo", "given": "Smadar", "initials": "S"}, {"family": "Rossman", "given": "Hagai", "initials": "H"}, {"family": "Gavrieli", "given": "Amir", "initials": "A"}, {"family": "Meir", "given": "Tomer", "initials": "T"}, {"family": "Lavon", "given": "Amit", "initials": "A"}, {"family": "Kolobkov", "given": "Dmitry", "initials": "D"}, {"family": "Kalka", "given": "Iris", "initials": "I"}, {"family": "Godneva", "given": "Anastasia", "initials": "A"}, {"family": "Cohen", "given": "Ori", "initials": "O"}, {"family": "Kariv", "given": "Adam", "initials": "A"}, {"family": "Hoch", "given": "Ori", "initials": "O"}, {"family": "Zer-Aviv", "given": "Mushon", "initials": "M"}, {"family": "Castel", "given": "Noam", "initials": "N"}, {"family": "Sudre", "given": "Carole", "initials": "C"}, {"family": "Zohar", "given": "Anat Ekka", "initials": "AE"}, {"family": "Irony", "given": "Angela", "initials": "A"}, {"family": "Spector", "given": "Tim", "initials": "T"}, {"family": "Geiger", "given": "Benjamin", "initials": "B"}, {"family": "Hizi", "given": "Dorit", "initials": "D"}, {"family": "Shalev", "given": "Varda", "initials": "V"}, {"family": "Balicer", "given": "Ran", "initials": "R"}, {"family": "Segal", "given": "Eran", "initials": "E"}], "type": "journal article", "published": "2020-10-10", "journal": {"title": "Med (N Y)", "issn": "2666-6340", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The gold standard for COVID-19 diagnosis is detection of viral RNA through PCR. Due to global limitations in testing capacity, effective prioritization of individuals for testing is essential.\r\n\r\nWe devised a model estimating the probability of an individual to test positive for COVID-19 based on answers to 9 simple questions that have been associated with COVID-19 infection. Our model was devised from a subsample of a national symptom survey that was answered over 2 million times in Israel in its first 2 months and a targeted survey distributed to all residents of several cities in Israel. Overall, 43,752 adults were included, from which 498 self-reported as being COVID-19 positive.\r\n\r\nOur model was validated on a held-out set of individuals from Israel where it achieved an auROC of 0.737 (CI: 0.712-0.759), auPR of 0.144 (CI: 0.119-0.177) and demonstrated its applicability outside of Israel in an independently-collected symptom survey dataset from the U.S., U.K. and Sweden.Our analyses revealed interactions between several symptoms and age, suggesting variation in the clinical manifestation of the disease in different age groups.\r\n\r\nour tool can be used online and without exposure to suspected patients, thus suggesting worldwide utility in combating COVID-19 by better directing the limited testing resources through prioritization of individuals for testing, thereby increasing the rate at which positive individuals can be identified. Moreover, individuals at high risk for a positive test result can be isolated prior to testing.", "doi": "10.1016/j.medj.2020.10.002", "pmid": "33073258", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2666-6340(20)30019-2"}, {"db": "pmc", "key": "PMC7547576"}], "notes": [], "created": "2020-11-27T11:50:21.127Z", "modified": "2022-11-09T08:58:28.888Z"}, {"entity": "publication", "iuid": "bb9e41d5e6b0498f97833c6922ab9c73", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bb9e41d5e6b0498f97833c6922ab9c73.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bb9e41d5e6b0498f97833c6922ab9c73"}}, "title": "More Than Smell-COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis.", "authors": [{"family": "Parma", "given": "Valentina", "initials": "V"}, {"family": "Ohla", "given": "Kathrin", "initials": "K"}, {"family": "Veldhuizen", "given": "Maria G", "initials": "MG"}, {"family": "Niv", "given": "Masha Y", "initials": "MY"}, {"family": "Kelly", "given": "Christine E", "initials": "CE"}, {"family": "Bakke", "given": "Alyssa J", "initials": "AJ"}, {"family": "Cooper", "given": "Keiland W", "initials": "KW"}, {"family": "Bouysset", "given": "C\u00e9dric", "initials": "C"}, {"family": "Pirastu", "given": "Nicola", "initials": "N"}, {"family": "Dibattista", "given": "Michele", "initials": "M"}, {"family": "Kaur", "given": "Rishemjit", "initials": "R"}, {"family": "Liuzza", "given": "Marco Tullio", "initials": "MT"}, {"family": "Pepino", "given": "Marta Y", "initials": "MY"}, {"family": "Sch\u00f6pf", "given": "Veronika", "initials": "V"}, {"family": "Pereda-Loth", "given": "Veronica", "initials": "V"}, {"family": "Olsson", "given": "Shannon B", "initials": "SB"}, {"family": "Gerkin", "given": "Richard C", "initials": "RC"}, {"family": "Rohlfs Dom\u00ednguez", "given": "Paloma", "initials": "P"}, {"family": "Albayay", "given": "Javier", "initials": "J"}, {"family": "Farruggia", "given": "Michael C", "initials": "MC"}, {"family": "Bhutani", "given": "Surabhi", "initials": "S"}, {"family": "Fjaeldstad", "given": "Alexander W", "initials": "AW"}, {"family": "Kumar", "given": "Ritesh", "initials": "R"}, {"family": "Menini", "given": "Anna", "initials": "A"}, {"family": "Bensafi", "given": "Moustafa", "initials": "M"}, {"family": "Sandell", "given": "Mari", "initials": "M"}, {"family": "Konstantinidis", "given": "Iordanis", "initials": "I"}, {"family": "Di Pizio", "given": "Antonella", "initials": "A"}, {"family": "Genovese", "given": "Federica", "initials": "F"}, {"family": "\u00d6zt\u00fcrk", "given": "Lina", "initials": "L"}, {"family": "Thomas-Danguin", "given": "Thierry", "initials": "T"}, {"family": "Frasnelli", "given": "Johannes", "initials": "J"}, {"family": "Boesveldt", "given": "Sanne", "initials": "S"}, {"family": "Saatci", "given": "\u00d6zlem", "initials": "\u00d6"}, {"family": "Saraiva", "given": "Luis R", "initials": "LR"}, {"family": "Lin", "given": "Cailu", "initials": "C"}, {"family": "Golebiowski", "given": "J\u00e9r\u00f4me", "initials": "J"}, {"family": "Hwang", "given": "Liang-Dar", "initials": "L"}, {"family": "Ozdener", "given": "Mehmet Hakan", "initials": "MH"}, {"family": "Gu\u00e0rdia", "given": "Maria Dolors", "initials": "MD"}, {"family": "Laudamiel", "given": "Christophe", "initials": "C"}, {"family": "Ritchie", "given": "Marina", "initials": "M"}, {"family": "Havl\u00edcek", "given": "Jan", "initials": "J"}, {"family": "Pierron", "given": "Denis", "initials": "D"}, {"family": "Roura", "given": "Eugeni", "initials": "E"}, {"family": "Navarro", "given": "Marta", "initials": "M"}, {"family": "Nolden", "given": "Alissa A", "initials": "AA"}, {"family": "Lim", "given": "Juyun", "initials": "J"}, {"family": "Whitcroft", "given": "Katherine L", "initials": "KL"}, {"family": "Colquitt", "given": "Lauren R", "initials": "LR"}, {"family": "Ferdenzi", "given": "Camille", "initials": "C"}, {"family": "Brindha", "given": "Evelyn V", "initials": "EV"}, {"family": "Altundag", "given": "Aytug", "initials": "A"}, {"family": "Macchi", "given": "Alberto", "initials": "A"}, {"family": "Nunez-Parra", "given": "Alexia", "initials": "A"}, {"family": "Patel", "given": "Zara M", "initials": "ZM"}, {"family": "Fiorucci", "given": "S\u00e9bastien", "initials": "S"}, {"family": "Philpott", "given": "Carl M", "initials": "CM"}, {"family": "Smith", "given": "Barry C", "initials": "BC"}, {"family": "Lundstr\u00f6m", "given": "Johan N", "initials": "JN"}, {"family": "Mucignat", "given": "Carla", "initials": "C"}, {"family": "Parker", "given": "Jane K", "initials": "JK"}, {"family": "van den Brink", "given": "Mirjam", "initials": "M"}, {"family": "Schmuker", "given": "Michael", "initials": "M"}, {"family": "Fischmeister", "given": "Florian Ph S", "initials": "FPS"}, {"family": "Heinbockel", "given": "Thomas", "initials": "T"}, {"family": "Shields", "given": "Vonnie D C", "initials": "VDC"}, {"family": "Faraji", "given": "Farhoud", "initials": "F"}, {"family": "Santamar\u00eda", "given": "Enrique", "initials": "E"}, {"family": "Fredborg", "given": "William E A", "initials": "WEA"}, {"family": "Morini", "given": "Gabriella", "initials": "G"}, {"family": "Olofsson", "given": "Jonas K", "initials": "JK"}, {"family": "Jalessi", "given": "Maryam", "initials": "M"}, {"family": "Karni", "given": "Noam", "initials": "N"}, {"family": "D'Errico", "given": "Anna", "initials": "A"}, {"family": "Alizadeh", "given": "Rafieh", "initials": "R"}, {"family": "Pellegrino", "given": "Robert", "initials": "R"}, {"family": "Meyer", "given": "Pablo", "initials": "P"}, {"family": "Huart", "given": "Caroline", "initials": "C"}, {"family": "Chen", "given": "Ben", "initials": "B"}, {"family": "Soler", "given": "Graciela M", "initials": "GM"}, {"family": "Alwashahi", "given": "Mohammed K", "initials": "MK"}, {"family": "Welge-L\u00fcssen", "given": "Antje", "initials": "A"}, {"family": "Freiherr", "given": "Jessica", "initials": "J"}, {"family": "de Groot", "given": "Jasper H B", "initials": "JHB"}, {"family": "Klein", "given": "Hadar", "initials": "H"}, {"family": "Okamoto", "given": "Masako", "initials": "M"}, {"family": "Singh", "given": "Preet Bano", "initials": "PB"}, {"family": "Hsieh", "given": "Julien W", "initials": "JW"}, {"family": "GCCR Group Author", "given": "", "initials": ""}, {"family": "Reed", "given": "Danielle R", "initials": "DR"}, {"family": "Hummel", "given": "Thomas", "initials": "T"}, {"family": "Munger", "given": "Steven D", "initials": "SD"}, {"family": "Hayes", "given": "John E", "initials": "JE"}], "type": "journal article", "published": "2020-10-09", "journal": {"title": "Chem Senses", "issn": "1464-3553", "issn-l": "0379-864X", "volume": "45", "issue": "7", "pages": "609-622"}, "abstract": "Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change \u00b1100) revealed a mean reduction of smell (-79.7 \u00b1 28.7, mean \u00b1 standard deviation), taste (-69.0 \u00b1 32.6), and chemesthetic (-37.3 \u00b1 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.", "doi": "10.1093/chemse/bjaa041", "pmid": "32564071", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "5860460"}, {"db": "pmc", "key": "PMC7337664"}], "notes": [], "created": "2020-12-08T16:36:10.943Z", "modified": "2021-06-17T08:27:50.863Z"}, {"entity": "publication", "iuid": "b0f0deb544914e6da3b55eb7fa321c80", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b0f0deb544914e6da3b55eb7fa321c80.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b0f0deb544914e6da3b55eb7fa321c80"}}, "title": "Beyond COVID-19-a paradigm shift in infection management?", "authors": [{"family": "Vehreschild", "given": "Maria J G T", "initials": "MJGT"}, {"family": "Tacconelli", "given": "Evelina", "initials": "E"}, {"family": "Giske", "given": "Christian G", "initials": "CG"}, {"family": "Peschel", "given": "Andreas", "initials": "A"}], "type": "letter", "published": "2020-10-09", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1016/S1473-3099(20)30789-1", "pmid": "33045187", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(20)30789-1"}, {"db": "pmc", "key": "PMC7546645"}], "notes": [], "created": "2020-12-01T17:16:03.841Z", "modified": "2020-12-01T17:16:03.868Z"}, {"entity": "publication", "iuid": "4f2ba3380aa140688274e008ceb51960", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4f2ba3380aa140688274e008ceb51960.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4f2ba3380aa140688274e008ceb51960"}}, "title": "A population-based cohort study of socio-demographic risk factors for COVID-19 deaths in Sweden.", "authors": [{"family": "Drefahl", "given": "Sven", "initials": "S"}, {"family": "Wallace", "given": "Matthew", "initials": "M"}, {"family": "Mussino", "given": "Eleonora", "initials": "E"}, {"family": "Aradhya", "given": "Siddartha", "initials": "S"}, {"family": "Kolk", "given": "Martin", "initials": "M"}, {"family": "Brand\u00e9n", "given": "Maria", "initials": "M"}, {"family": "Malmberg", "given": "Bo", "initials": "B"}, {"family": "Andersson", "given": "Gunnar", "initials": "G"}], "type": "journal article", "published": "2020-10-09", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "11", "issue": "1", "pages": "5097"}, "abstract": "As global deaths from COVID-19 continue to rise, the world's governments, institutions, and agencies are still working toward an understanding of who is most at risk of death. In this study, data on all recorded COVID-19 deaths in Sweden up to May 7, 2020 are linked to high-quality and accurate individual-level background data from administrative registers of the total population. By means of individual-level survival analysis we demonstrate that being male, having less individual income, lower education, not being married all independently predict a higher risk of death from COVID-19 and from all other causes of death. Being an immigrant from a low- or middle-income country predicts higher risk of death from COVID-19 but not for all other causes of death. The main message of this work is that the interaction of the virus causing COVID-19 and its social environment exerts an unequal burden on the most disadvantaged members of society.", "doi": "10.1038/s41467-020-18926-3", "pmid": "33037218", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-020-18926-3"}, {"db": "pmc", "key": "PMC7547672"}], "notes": [], "created": "2020-12-01T17:25:48.061Z", "modified": "2022-11-09T08:59:59.030Z"}, {"entity": "publication", "iuid": "6b71d3289aed493a916aaaca1fbb2ea6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b71d3289aed493a916aaaca1fbb2ea6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b71d3289aed493a916aaaca1fbb2ea6"}}, "title": "What every Researcher should know about Searching - Clarified Concepts, Search Advice, and an Agenda to improve Finding in Academia.", "authors": [{"family": "Gusenbauer", "given": "Michael", "initials": "M"}, {"family": "Haddaway", "given": "Neal R", "initials": "NR"}], "type": "journal article", "published": "2020-10-08", "journal": {"title": "Res Synth Methods", "issn": "1759-2887", "volume": null, "issue": null, "issn-l": null}, "abstract": "We researchers have taken searching for information for granted for far too long. The COVID-19 pandemic shows us the boundaries of academic searching capabilities, both in terms of our know-how and of the systems we have. With hundreds of studies published daily on COVID-19, for example, we struggle to find, stay up-to-date, and synthesize information-all hampering evidence-informed decision making. This COVID-19 information crisis is indicative of the broader problem of information overloaded academic research. To improve our finding capabilities, we urgently need to improve how we search and the systems we use. We respond to Klopfenstein and Dampier (Res Syn Meth. 2020) who commented on our 2020 paper and proposed a way of improving PubMed's and Google Scholar's search functionalities. Our response puts their commentary in a larger frame and suggests how we can improve academic searching altogether. We urge that researchers need to understand that search skills require dedicated education and training. Better and more efficient searching requires an initial understanding of the different goals that define the way searching needs to be conducted. We explain the main types of searching that we academics routinely engage in; distinguishing lookup, exploratory, and systematic searching. These three types must be conducted using different search methods (heuristics) and using search systems with specific capabilities. To improve academic searching, we introduce the \"Search Triangle\" model emphasizing the importance of matching goals, heuristics, and systems. Further, we suggest an urgently needed agenda toward search literacy as the norm in academic research and fit-for-purpose search systems.", "doi": "10.1002/jrsm.1457", "pmid": "33031639", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-01T17:31:05.757Z", "modified": "2020-12-01T17:31:05.783Z"}, {"entity": "publication", "iuid": "d94e32a234a0498cbac9b9f2af96a362", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d94e32a234a0498cbac9b9f2af96a362.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d94e32a234a0498cbac9b9f2af96a362"}}, "title": "SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden.", "authors": [{"family": "Rudberg", "given": "Ann-Sofie", "initials": "AS", "orcid": "0000-0003-3616-9943", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e7acfc6023c44aa2a878fbacc3dba7fb.json"}}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c735ef404391493980e4e51d70459ce0.json"}}, {"family": "Jernbom Falk", "given": "August", "initials": "A", "orcid": "0000-0002-7773-1851", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/40d944d7fa964f4292f10012356a2730.json"}}, {"family": "Aguilera", "given": "Katherina", "initials": "K"}, {"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/305bca9e5c6c423898c272bf06ce2f2a.json"}}, {"family": "Gabrielsson", "given": "Lena", "initials": "L"}, {"family": "Salomonsson", "given": "Ann-Christin", "initials": "AC"}, {"family": "Hanke", "given": "Leo", "initials": "L", "orcid": "0000-0001-5514-2418", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a35f10de4f2e4aee98278f6ab845613d.json"}}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "McInerney", "given": "Gerald", "initials": "G", "orcid": "0000-0003-2257-7241", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7770437d845444a8a07865bf5b62fab0.json"}}, {"family": "Olofsson", "given": "Jennie", "initials": "J"}, {"family": "Andersson", "given": "Eni", "initials": "E", "orcid": "0000-0002-5115-0637", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f8200b399e954f3482aec53a62df3b54.json"}}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C", "orcid": "0000-0003-0880-5375", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7394cf1c96945888fc8765568f5407c.json"}}, {"family": "Bayati", "given": "Shaghayegh", "initials": "S"}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Sj\u00f6berg", "given": "Ronald", "initials": "R"}, {"family": "Tegel", "given": "Hanna", "initials": "H"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0fce0587c3584cf3bd2ac3025e954c9c.json"}}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/78d786c0d7984041a2b4bc67f7ee799f.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1345-6491", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a53a433db6f04a458e3d420f0c9995c5.json"}}], "type": "journal article", "published": "2020-10-08", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "11", "issue": "1", "pages": "5064"}, "abstract": "SARS-CoV-2 may pose an occupational health risk to healthcare workers. Here, we report the seroprevalence of SARS-CoV-2 antibodies, self-reported symptoms and occupational exposure to SARS-CoV-2 among healthcare workers at a large acute care hospital in Sweden. The seroprevalence of IgG antibodies against SARS-CoV-2 was 19.1% among the 2149 healthcare workers recruited between April 14th and May 8th 2020, which was higher than the reported regional seroprevalence during the same time period. Symptoms associated with seroprevalence were anosmia (odds ratio (OR) 28.4, 95% CI 20.6-39.5) and ageusia (OR 19.2, 95% CI 14.3-26.1). Seroprevalence was also associated with patient contact (OR 2.9, 95% CI 1.9-4.5) and covid-19 patient contact (OR 3.3, 95% CI 2.2-5.3). These findings imply an occupational risk for SARS-CoV-2 infection among healthcare workers. Continued measures are warranted to assure healthcare workers safety and reduce transmission from healthcare workers to patients and to the community.", "doi": "10.1038/s41467-020-18848-0", "pmid": "33033249", "labels": {"Type: Journal article": null, "Research Area: Biobanks for COVID-19 research": null, "Funder: KAW/SciLifeLab": null, "Research Area: High-throughput and high-content serology": null, "Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Funder: H2020": null, "Category: Health": null, "Category: Serology": null}, "xrefs": [{"db": "pmc", "key": "PMC7544689"}, {"db": "pii", "key": "10.1038/s41467-020-18848-0"}], "notes": [], "created": "2020-10-30T11:46:40.143Z", "modified": "2023-06-19T14:24:22.660Z"}, {"entity": "publication", "iuid": "7c590b4e9a234f918c74726c082da341", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7c590b4e9a234f918c74726c082da341.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7c590b4e9a234f918c74726c082da341"}}, "title": "Living with the COVID-19 pandemic: act now with the tools we have.", "authors": [{"family": "Bedford", "given": "Juliet", "initials": "J"}, {"family": "Enria", "given": "Delia", "initials": "D"}, {"family": "Giesecke", "given": "Johan", "initials": "J"}, {"family": "Heymann", "given": "David L", "initials": "DL"}, {"family": "Ihekweazu", "given": "Chikwe", "initials": "C"}, {"family": "Kobinger", "given": "Gary", "initials": "G"}, {"family": "Lane", "given": "H Clifford", "initials": "HC"}, {"family": "Memish", "given": "Ziad A", "initials": "ZA"}, {"family": "Oh", "given": "Myoung-Don", "initials": "MD"}, {"family": "Sall", "given": "Amadou Alpha", "initials": "AA"}, {"family": "Ungchusak", "given": "Kumnuan", "initials": "K"}, {"family": "Wieler", "given": "Lothar H", "initials": "LH"}, {"family": "WHO Strategic and Technical Advisory Group for Infectious Hazards", "given": "", "initials": ""}], "type": "journal article", "published": "2020-10-08", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": null, "issue": null, "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)32117-6", "pmid": "33038947", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)32117-6"}, {"db": "pmc", "key": "PMC7544497"}], "notes": [], "created": "2020-12-01T17:21:13.505Z", "modified": "2020-12-01T17:21:13.515Z"}, {"entity": "publication", "iuid": "64e939415762403c9009f86ec14f76ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/64e939415762403c9009f86ec14f76ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/64e939415762403c9009f86ec14f76ef"}}, "title": "Intravenous immunoglobulin therapy in COVID-19-related encephalopathy.", "authors": [{"family": "Muccioli", "given": "Lorenzo", "initials": "L"}, {"family": "Pensato", "given": "Umberto", "initials": "U"}, {"family": "Bernab\u00e8", "given": "Giorgia", "initials": "G"}, {"family": "Ferri", "given": "Lorenzo", "initials": "L"}, {"family": "Tappat\u00e0", "given": "Maria", "initials": "M"}, {"family": "Volpi", "given": "Lilia", "initials": "L"}, {"family": "Cani", "given": "Ilaria", "initials": "I"}, {"family": "Henry", "given": "Olivia J", "initials": "OJ"}, {"family": "Ceccaroni", "given": "Francesca", "initials": "F"}, {"family": "Cevoli", "given": "Sabina", "initials": "S"}, {"family": "Stofella", "given": "Gloria", "initials": "G"}, {"family": "Pasini", "given": "Elena", "initials": "E"}, {"family": "Fornaro", "given": "Giacomo", "initials": "G"}, {"family": "Tonon", "given": "Caterina", "initials": "C"}, {"family": "Vidale", "given": "Simone", "initials": "S"}, {"family": "Liguori", "given": "Rocco", "initials": "R"}, {"family": "Tinuper", "given": "Paolo", "initials": "P"}, {"family": "Michelucci", "given": "Roberto", "initials": "R"}, {"family": "Cortelli", "given": "Pietro", "initials": "P"}, {"family": "Bisulli", "given": "Francesca", "initials": "F"}], "type": "journal article", "published": "2020-10-08", "journal": {"title": "J Neurol", "issn": "1432-1459", "volume": null, "issue": null, "issn-l": null}, "abstract": "To report on efficacy and safety of intravenous immunoglobulin (IVIg) therapy in a case series of patients with COVID-19-related encephalopathy.\n\nWe retrospectively collected data on all patients with COVID-19 hospitalized at two Italian hospitals who developed encephalopathy during disease course and were treated with IVIg.\n\nFive patients (two females, mean age 66.8 years) developed encephalopathy after a mean of 12.6 days, since the onset of respiratory/constitutional symptoms related to COVID-19. Four patients suffered severe respiratory distress, three of which required invasive mechanical ventilation. Neurological manifestations included impaired consciousness, agitation, delirium, pyramidal and extrapyramidal signs. EEG demonstrated diffuse slowing in all patients. Brain MRI showed non-specific findings. CSF analysis revealed normal cell count and protein levels. In all subjects, RT-PCR for SARS-CoV-2 in CSF tested negative. IVIg at 0.4 g/kg/die was commenced 29.8 days (mean, range: 19-55 days) after encephalopathy onset, leading to complete electroclinical recovery in all patients, with an initial improvement of neuropsychiatric symptoms observed in 3.4 days (mean, range: 1-10 days). No adverse events related to IVIg were observed.\n\nOur preliminary findings suggest that IVIg may represent a safe and effective treatment for COVID-19-associated encephalopathy. Clinical efficacy may be driven by the anti-inflammatory action of IVIg, associated with its anti-cytokine qualities.", "doi": "10.1007/s00415-020-10248-0", "pmid": "33030607", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00415-020-10248-0"}, {"db": "pmc", "key": "PMC7543032"}], "notes": [], "created": "2020-12-01T17:32:59.107Z", "modified": "2021-02-26T08:45:48.261Z"}, {"entity": "publication", "iuid": "b327cae0f4e3414480b4ac802d8a4bd0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b327cae0f4e3414480b4ac802d8a4bd0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b327cae0f4e3414480b4ac802d8a4bd0"}}, "title": "Airborne spread of infectious SARS-CoV-2: Moving forward using lessons from SARS-CoV and MERS-CoV.", "authors": [{"family": "da Silva", "given": "Priscilla Gomes", "initials": "PG"}, {"family": "Nascimento", "given": "Maria S\u00e3o Jos\u00e9", "initials": "MSJ"}, {"family": "Soares", "given": "Ruben R G", "initials": "RRG"}, {"family": "Sousa", "given": "Sofia I V", "initials": "SIV"}, {"family": "Mesquita", "given": "Jo\u00e3o R", "initials": "JR"}], "type": "journal article", "published": "2020-10-08", "journal": {"title": "Sci Total Environ", "issn": "1879-1026", "volume": null, "issue": null, "pages": "142802", "issn-l": "0048-9697"}, "abstract": "Although an increasing body of data reports the detection of SARS-CoV-2 RNA in air, this does not correlate to the presence of infectious viruses, thus not evaluating the risk for airborne COVID-19. Hence there is a marked knowledge gap that requires urgent attention. Therefore, in this systematic review, viability/stability of airborne SARS-CoV-2, SARS-CoV and MERS-CoV viruses is discussed.\n\nA systematic literature review was performed on PubMed/MEDLINE, Web of Science and Scopus to assess the stability and viability of SARS-CoV, MERS-CoV and SARS-CoV-2 on air samples.\n\nThe initial search identified 27 articles. Following screening of titles and abstracts and removing duplicates, 11 articles were considered relevant. Temperatures ranging from 20 \u00b0C to 25 \u00b0C and relative humidity ranging from 40% to 50% were reported to have a protective effect on viral viability for airborne SARS-CoV and MERS-CoV. As no data is yet available on the conditions influencing viability for airborne SARS-CoV-2, and given the genetic similarity to SARS-CoV and MERS-CoV, one could extrapolate that the same conditions would apply. Nonetheless, the effect of these conditions seems to be residual considering the increasing number of cases in the south of USA, Brazil and India, where high temperatures and humidities have been observed.\n\nHigher temperatures and high relative humidity can have a modest effect on SARS-CoV-2 viability in the environment, as reported in previous studies to this date. However, these studies are experimental, and do not support the fact that the virus has efficiently spread in the tropical regions of the globe, with other transmission routes such as the contact and droplet ones probably being responsible for the majority of cases reported in these regions, along with other factors such as human mobility patterns and contact rates. Further studies are needed to investigate the extent of aerosol transmission of SARS-CoV-2 as this would have important implications for public health and infection-control policies.", "doi": "10.1016/j.scitotenv.2020.142802", "pmid": "33071145", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0048-9697(20)36331-2"}, {"db": "pmc", "key": "PMC7543729"}], "notes": [], "created": "2020-11-27T11:51:35.091Z", "modified": "2020-12-01T17:05:19.632Z"}, {"entity": "publication", "iuid": "25657ae6d3c7476b9a979baf93ddb9f3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/25657ae6d3c7476b9a979baf93ddb9f3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/25657ae6d3c7476b9a979baf93ddb9f3"}}, "title": "Psychological distress among Iranian health-care providers exposed to coronavirus disease 2019 (COVID-19): a qualitative study.", "authors": [{"family": "Alizadeh", "given": "Azizeh", "initials": "A"}, {"family": "Khankeh", "given": "Hamid Reza", "initials": "HR"}, {"family": "Barati", "given": "Mohammad", "initials": "M"}, {"family": "Ahmadi", "given": "Yazdan", "initials": "Y"}, {"family": "Hadian", "given": "Arash", "initials": "A"}, {"family": "Azizi", "given": "Maryam", "initials": "M"}], "type": "journal article", "published": "2020-10-07", "journal": {"title": "BMC Psychiatry", "issn": "1471-244X", "issn-l": null, "volume": "20", "issue": "1", "pages": "494"}, "abstract": "Novel corona virus, named COVID-19, has spread rapidly to other countries like Italy, Iran and South Korea and affected all people, especially health-care providers. Therefore, due to the rapid spread of the disease in Iran, the aim of the present study was to explore psychological distress experienced by Iranian health-care providers in the first few weeks of the corona virus outbreak.\r\n\r\nThe present qualitative study was conducted on 18 Iranian health-care providers exposed to COVID - 19 using a content analysis method. Purposeful sampling was used to select the participants and continued until data saturation was reached. Data were collected using semi-structured interviews and then the qualitative data were analyzed through direct content analysis.\r\n\r\nBy analyzing 236 primary codes, two main categories were extracted from the experiences of health-care providers during corona virus outbreak. The first category included Occupational demands with three sub-categories: nature of illness, Organizational demands and social demands. The second category was Supportive resources included personal support and social support.\r\n\r\nThe results of this study found that there were some barriers and challenges to medical personnel exposed to COVID-19 that caused psychological distress. Some of these problems related to the nature of illness, others related to social and organizational demands and some of supportive resources buffer the relationship between occupational demands and psychological distress.", "doi": "10.1186/s12888-020-02889-2", "pmid": "33028290", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12888-020-02889-2"}, {"db": "pmc", "key": "PMC7538532"}], "notes": [], "created": "2020-12-03T08:51:27.977Z", "modified": "2022-11-09T09:00:38.111Z"}, {"entity": "publication", "iuid": "932740d940544f29a914b99552819522", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/932740d940544f29a914b99552819522.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/932740d940544f29a914b99552819522"}}, "title": "Were clinical routines for good end-of-life care maintained in hospitals and nursing homes during the first three months of the outbreak of COVID-19? A national register study.", "authors": [{"family": "Martinsson", "given": "Lisa", "initials": "L"}, {"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "Bergstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Staffan", "initials": "S"}], "type": "journal article", "published": "2020-10-06", "journal": {"title": "J Pain Symptom Manage", "issn": "1873-6513", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Although the COVID-19 pandemic might affect important clinical routines, few studies have focused on the maintenance of good quality in end-of-life care.\r\n\r\nThe objective was to examine whether adherence to clinical routines for good end-of-life care differed for deaths due to COVID-19 compared to a reference cohort from 2019, and whether they differed between nursing homes and hospitals.\r\n\r\nData about five items reflecting clinical routines for persons who died an expected death from COVID-19 during the first three months of the pandemic (March-May 2020) were collected from the Swedish Register of Palliative Care. The items were compared between the COVID-19 group and the reference cohort, and between the nursing home and hospital COVID-19 deaths.\r\n\r\n1316 expected deaths were identified in nursing homes and 685 in hospitals. Four of the five items differed for total COVID-19 group compared to the reference cohort: fewer were examined by a physician during the last days before death, pain and oral health were less likely to be assessed, and fewer had had a specialised palliative care team consultation (p < .0001, respectively). Assessment of symptoms other than pain did not differ significantly. The five items differed between the nursing homes and hospitals in the COVID-19 group, most notably regarding the proportion of persons examined by a physician during the last days (nursing homes - 18%, hospitals - 100%).\r\n\r\nThis national register study shows that several clinical routines for end-of-life care did not meet the usual standards during the first three months of the COVID-19 pandemic in Sweden. Higher preparedness for and monitoring of end-of-life care quality should be integrated into future pandemic plans.", "doi": "10.1016/j.jpainsymman.2020.09.043", "pmid": "33035649", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0885-3924(20)30794-6"}, {"db": "pmc", "key": "PMC7538392"}], "notes": [], "created": "2020-12-01T17:29:08.233Z", "modified": "2021-02-26T08:47:00.076Z"}, {"entity": "publication", "iuid": "5df1142a5d38410a8a9d94601249e1fe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5df1142a5d38410a8a9d94601249e1fe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5df1142a5d38410a8a9d94601249e1fe"}}, "title": "Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study.", "authors": [{"family": "Burn", "given": "Edward", "initials": "E"}, {"family": "You", "given": "Seng Chan", "initials": "SC"}, {"family": "Sena", "given": "Anthony G", "initials": "AG"}, {"family": "Kostka", "given": "Kristin", "initials": "K"}, {"family": "Abedtash", "given": "Hamed", "initials": "H"}, {"family": "Abrah\u00e3o", "given": "Maria Tereza F", "initials": "MTF"}, {"family": "Alberga", "given": "Amanda", "initials": "A"}, {"family": "Alghoul", "given": "Heba", "initials": "H"}, {"family": "Alser", "given": "Osaid", "initials": "O"}, {"family": "Alshammari", "given": "Thamir M", "initials": "TM"}, {"family": "Aragon", "given": "Maria", "initials": "M"}, {"family": "Areia", "given": "Carlos", "initials": "C"}, {"family": "Banda", "given": "Juan M", "initials": "JM"}, {"family": "Cho", "given": "Jaehyeong", "initials": "J"}, {"family": "Culhane", "given": "Aedin C", "initials": "AC"}, {"family": "Davydov", "given": "Alexander", "initials": "A"}, {"family": "DeFalco", "given": "Frank J", "initials": "FJ"}, {"family": "Duarte-Salles", "given": "Talita", "initials": "T"}, {"family": "DuVall", "given": "Scott", "initials": "S"}, {"family": "Falconer", "given": "Thomas", "initials": "T"}, {"family": "Fernandez-Bertolin", "given": "Sergio", "initials": "S"}, {"family": "Gao", "given": "Weihua", "initials": "W"}, {"family": "Golozar", "given": "Asieh", "initials": "A"}, {"family": "Hardin", "given": "Jill", "initials": "J"}, {"family": "Hripcsak", "given": "George", "initials": "G"}, {"family": "Huser", "given": "Vojtech", "initials": "V"}, {"family": "Jeon", "given": "Hokyun", "initials": "H"}, {"family": "Jing", "given": "Yonghua", "initials": "Y"}, {"family": "Jung", "given": "Chi Young", "initials": "CY"}, {"family": "Kaas-Hansen", "given": "Benjamin Skov", "initials": "BS"}, {"family": "Kaduk", "given": "Denys", "initials": "D"}, {"family": "Kent", "given": "Seamus", "initials": "S"}, {"family": "Kim", "given": "Yeesuk", "initials": "Y"}, {"family": "Kolovos", "given": "Spyros", "initials": "S"}, {"family": "Lane", "given": "Jennifer C E", "initials": "JCE"}, {"family": "Lee", "given": "Hyejin", "initials": "H"}, {"family": "Lynch", "given": "Kristine E", "initials": "KE"}, {"family": "Makadia", "given": "Rupa", "initials": "R"}, {"family": "Matheny", "given": "Michael E", "initials": "ME"}, {"family": "Mehta", "given": "Paras P", "initials": "PP"}, {"family": "Morales", "given": "Daniel R", "initials": "DR"}, {"family": "Natarajan", "given": "Karthik", "initials": "K"}, {"family": "Nyberg", "given": "Fredrik", "initials": "F"}, {"family": "Ostropolets", "given": "Anna", "initials": "A"}, {"family": "Park", "given": "Rae Woong", "initials": "RW"}, {"family": "Park", "given": "Jimyung", "initials": "J"}, {"family": "Posada", "given": "Jose D", "initials": "JD"}, {"family": "Prats-Uribe", "given": "Albert", "initials": "A"}, {"family": "Rao", "given": "Gowtham", "initials": "G"}, {"family": "Reich", "given": "Christian", "initials": "C"}, {"family": "Rho", "given": "Yeunsook", "initials": "Y"}, {"family": "Rijnbeek", "given": "Peter", "initials": "P"}, {"family": "Schilling", "given": "Lisa M", "initials": "LM"}, {"family": "Schuemie", "given": "Martijn", "initials": "M"}, {"family": "Shah", "given": "Nigam H", "initials": "NH"}, {"family": "Shoaibi", "given": "Azza", "initials": "A"}, {"family": "Song", "given": "Seokyoung", "initials": "S"}, {"family": "Spotnitz", "given": "Matthew", "initials": "M"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Swerdel", "given": "Joel N", "initials": "JN"}, {"family": "Vizcaya", "given": "David", "initials": "D"}, {"family": "Volpe", "given": "Salvatore", "initials": "S"}, {"family": "Wen", "given": "Haini", "initials": "H"}, {"family": "Williams", "given": "Andrew E", "initials": "AE"}, {"family": "Yimer", "given": "Belay B", "initials": "BB"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhuk", "given": "Oleg", "initials": "O"}, {"family": "Prieto-Alhambra", "given": "Daniel", "initials": "D"}, {"family": "Ryan", "given": "Patrick", "initials": "P"}], "type": "journal article", "published": "2020-10-06", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "11", "issue": "1", "pages": "5009"}, "abstract": "Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. Here, we describe the characteristics of adults hospitalised with COVID-19 and compare them with influenza patients. We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) COVID-19 patients, summarising between 4811 and 11,643 unique aggregate characteristics. COVID-19 patients have been majority male in the US and Spain, but predominantly female in South Korea. Age profiles vary across data sources. Compared to 84,585 individuals hospitalised with influenza in 2014-19, COVID-19 patients have more typically been male, younger, and with fewer comorbidities and lower medication use. While protecting groups vulnerable to influenza is likely a useful starting point in the response to COVID-19, strategies will likely need to be broadened to reflect the particular characteristics of individuals being hospitalised with COVID-19.", "doi": "10.1038/s41467-020-18849-z", "pmid": "33024121", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-020-18849-z"}, {"db": "pmc", "key": "PMC7538555"}, {"db": "URL", "key": "http://evidence.ohdsi.org/Covid19CharacterizationHospitalization/.", "description": "http://evidence.ohdsi.org/Covid19CharacterizationHospitalization/."}, {"db": "URL", "key": "https://github.com/ohdsi-studies/Covid19HospitalizationCharacterization", "description": "https://github.com/ohdsi-studies/Covid19HospitalizationCharacterization"}], "notes": [], "created": "2020-11-27T12:39:00.134Z", "modified": "2023-01-13T09:49:38.516Z"}, {"entity": "publication", "iuid": "ec79c7a6fc0447b285f5e0f27b17d2ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec79c7a6fc0447b285f5e0f27b17d2ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec79c7a6fc0447b285f5e0f27b17d2ff"}}, "title": "Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2.", "authors": [{"family": "Rogstam", "given": "Annika", "initials": "A"}, {"family": "Nyblom", "given": "Maria", "initials": "M"}, {"family": "Christensen", "given": "Signe", "initials": "S"}, {"family": "Sele", "given": "Celeste", "initials": "C"}, {"family": "Talibov", "given": "Vladimir O", "initials": "VO"}, {"family": "Lindvall", "given": "Therese", "initials": "T"}, {"family": "Rasmussen", "given": "Anna Andersson", "initials": "AA"}, {"family": "Andr\u00e9", "given": "Ingemar", "initials": "I"}, {"family": "Fisher", "given": "Zo\u00eb", "initials": "Z"}, {"family": "Knecht", "given": "Wolfgang", "initials": "W"}, {"family": "Kozielski", "given": "Frank", "initials": "F"}], "type": "journal article", "published": "2020-10-06", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "21", "issue": "19", "issn-l": null}, "abstract": "Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), causing Coronavirus Disease 19 (COVID-19), emerged at the end of 2019 and quickly spread to cause a global pandemic with severe socio-economic consequences. The early sequencing of its RNA genome revealed its high similarity to SARS, likely to have originated from bats. The SARS-CoV-2 non-structural protein 10 (nsp10) displays high sequence similarity with its SARS homologue, which binds to and stimulates the 3'-to-5' exoribonuclease and the 2'-O-methlytransferase activities of nsps 14 and 16, respectively. Here, we report the biophysical characterization and 1.6 \u00c5 resolution structure of the unbound form of nsp10 from SARS-CoV-2 and compare it to the structures of its SARS homologue and the complex-bound form with nsp16 from SARS-CoV-2. The crystal structure and solution behaviour of nsp10 will not only form the basis for understanding the role of SARS-CoV-2 nsp10 as a central player of the viral RNA capping apparatus, but will also serve as a basis for the development of inhibitors of nsp10, interfering with crucial functions of the replication-transcription complex and virus replication.", "doi": "10.3390/ijms21197375", "pmid": "33036230", "labels": {"Type: Journal article": null, "Category: Proteins": null}, "xrefs": [{"db": "PDB", "key": "6ZPE", "description": "Nonstructural protein 10 (nsp10) from SARS CoV-2, 1.58\u00c5 resolution"}, {"db": "PDB", "key": "6ZCT", "description": "Nonstructural protein 10 (nsp10) from SARS CoV-2, 2.55\u00c5 resolution"}, {"db": "URL", "key": "http://www.mdpi.com/1422-0067/21/19/7375/s1", "description": "Supplementary materials"}], "notes": [], "created": "2020-10-30T11:23:12.306Z", "modified": "2021-02-26T08:47:18.875Z"}, {"entity": "publication", "iuid": "0846f729bebd46bab1412900525f7e54", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0846f729bebd46bab1412900525f7e54.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0846f729bebd46bab1412900525f7e54"}}, "title": "Upper Respiratory Tract Levels of Severe Acute Respiratory Syndrome Coronavirus 2 RNA and Duration of Viral RNA Shedding Do Not Differ Between Patients With Mild and Severe/Critical Coronavirus Disease 2019", "authors": [{"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Marklund", "given": "Emelie", "initials": "E"}, {"family": "Andersson", "given": "Maria", "initials": "M"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Andersson", "given": "Lars Magnus", "initials": "LM"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal-article", "published": "2020-10-05", "journal": {"title": "The Journal of Infectious Diseases", "issn": "0022-1899", "issn-l": null, "volume": "223", "issue": "1", "pages": "15-18"}, "abstract": "This study reports longitudinal viral RNA loads from the nasopharynx/throat in patients with mild and severe/critical coronavirus disease 2019 (COVID-19). We also investigated whether the duration of symptoms correlated with the duration of viral RNA shedding. A total of 56 patients were included. The highest viral loads occurred early after onset of symptoms. Neither the viral RNA loads in the upper respiratory tract nor the time to viral RNA clearance differed between patients with mild or severe/critical disease. There was a moderate correlation between number of days with symptoms and number of days with viral RNA shedding in patients with mild COVID-19.", "doi": "10.1093/infdis/jiaa632", "pmid": "33020822", "labels": {"Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Research Area: Biomarkers and systems immunology": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Genomics & transcriptomics": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-04T07:31:41.074Z", "modified": "2021-06-14T14:40:59.081Z"}, {"entity": "publication", "iuid": "f328480b01e246b5a1721e85548a034f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f328480b01e246b5a1721e85548a034f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f328480b01e246b5a1721e85548a034f"}}, "title": "Testing wastewater to detect severe acute respiratory syndrome coronavirus 2 in communities.", "authors": [{"family": "Harries", "given": "Anthony D", "initials": "AD"}, {"family": "Dar Berger", "given": "Selma", "initials": "S"}, {"family": "Satyanarayana", "given": "Srinath", "initials": "S"}, {"family": "Thekkur", "given": "Pruthu", "initials": "P"}, {"family": "Kumar", "given": "Ajay M V", "initials": "AMV"}], "type": "journal article", "published": "2020-10-05", "journal": {"title": "Trans R Soc Trop Med Hyg", "issn": "1878-3503", "volume": "114", "issue": "10", "pages": "782-783", "issn-l": null}, "abstract": "Research groups around the world are starting to analyse whether wastewater surveillance is a useful tool to monitor the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in communities. Reported studies from the Netherlands, USA, Australia and France have demonstrated that SARS-CoV-2 can be detected and quantified in wastewater, allowing the total number of community infections to be estimated as well as monitoring whether the virus has returned to a community after elimination. Further work is required to improve the quantification of virus, to better detect the virus at low levels and to ensure wastewater samples are representative of the community under surveillance.", "doi": "10.1093/trstmh/traa066", "pmid": "32780856", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "5891256"}, {"db": "pmc", "key": "PMC7454889"}], "notes": [], "created": "2020-12-07T13:32:00.162Z", "modified": "2021-02-26T08:46:13.601Z"}, {"entity": "publication", "iuid": "84b42d7543d34c9ea1ffec8a3f923dd5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84b42d7543d34c9ea1ffec8a3f923dd5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84b42d7543d34c9ea1ffec8a3f923dd5"}}, "title": "Comparing biomarkers for COVID-19 disease with commonly associated preexisting conditions and complications", "authors": [{"family": "Huang", "given": "Jesse", "initials": "J"}], "type": "posted-content", "published": "2020-10-05", "journal": {"title": "", "issn": null, "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1101/2020.10.02.20205609", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-09T19:34:36.434Z", "modified": "2021-06-09T19:34:49.113Z"}, {"entity": "publication", "iuid": "6564dde888cc467cbb4dcb65121bbd2d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6564dde888cc467cbb4dcb65121bbd2d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6564dde888cc467cbb4dcb65121bbd2d"}}, "title": "Safety and efficacy of the Russian COVID-19 vaccine: more information needed.", "authors": [{"family": "Bucci", "given": "Enrico", "initials": "E"}, {"family": "Andreev", "given": "Konstantin", "initials": "K"}, {"family": "Bj\u00f6rkman", "given": "Anders", "initials": "A"}, {"family": "Calogero", "given": "Raffaele Adolfo", "initials": "RA"}, {"family": "Carafoli", "given": "Ernesto", "initials": "E"}, {"family": "Carninci", "given": "Piero", "initials": "P"}, {"family": "Castagnoli", "given": "Paola", "initials": "P"}, {"family": "Cossarizza", "given": "Andrea", "initials": "A"}, {"family": "Mussini", "given": "Cristina", "initials": "C"}, {"family": "Guerin", "given": "Philippe", "initials": "P"}, {"family": "Lipworth", "given": "Brian", "initials": "B"}, {"family": "Sbardella", "given": "Gianluca", "initials": "G"}, {"family": "Stocki", "given": "Teresa", "initials": "T"}, {"family": "Tuosto", "given": "Loretta", "initials": "L"}, {"family": "van Tulleken", "given": "Christoffer", "initials": "C"}, {"family": "Viola", "given": "Antonella", "initials": "A"}], "type": "letter", "published": "2020-10-03", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "396", "issue": "10256", "pages": "e53", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)31960-7", "pmid": "32971041", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31960-7"}, {"db": "pmc", "key": "PMC7503114"}], "notes": [], "created": "2020-12-03T15:08:12.915Z", "modified": "2020-12-03T15:08:12.925Z"}, {"entity": "publication", "iuid": "ca305314e9bd443b94b3913fca99e324", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ca305314e9bd443b94b3913fca99e324.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ca305314e9bd443b94b3913fca99e324"}}, "title": "Improving on and assessing ethical guidelines for digital tracking and tracing systems for pandemics.", "authors": [{"family": "Lundgren", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2020-10-03", "journal": {"title": "Ethics Inf Technol", "issn": "1388-1957", "volume": null, "issue": null, "pages": "1-4", "issn-l": null}, "abstract": "So-called digital tracking and tracing systems (DTTSs) have been proposed as a means to prevent the spread of SARS-CoV-2. There are ethical guidelines and evaluations of such systems available. As part of a research project, I will build on and critically evaluate the foundations of such guidelines. The goal is to provide both incremental improvements of the specific requirements for DTTSs and to present and discuss more fundamental challenge, the risk for indirect effects and slippery slopes. The nature of slippery slopes makes ethical guidelines more difficult since it requires a more complex analysis than, for example, using a checklist allows for.", "doi": "10.1007/s10676-020-09561-z", "pmid": "33041647", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "9561"}, {"db": "pmc", "key": "PMC7532338"}], "notes": [], "created": "2020-12-01T17:20:29.348Z", "modified": "2020-12-01T17:20:29.360Z"}, {"entity": "publication", "iuid": "7b1e089b1173446884e09c71f0a18d9e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b1e089b1173446884e09c71f0a18d9e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b1e089b1173446884e09c71f0a18d9e"}}, "title": "The worldwide clinical trial research response to the COVID-19 pandemic - the first 100 days.", "authors": [{"family": "Janiaud", "given": "Perrine", "initials": "P"}, {"family": "Axfors", "given": "Cathrine", "initials": "C"}, {"family": "Van't Hooft", "given": "Janneke", "initials": "J"}, {"family": "Saccilotto", "given": "Ramon", "initials": "R"}, {"family": "Agarwal", "given": "Arnav", "initials": "A"}, {"family": "Appenzeller-Herzog", "given": "Christian", "initials": "C"}, {"family": "Contopoulos-Ioannidis", "given": "Despina G", "initials": "DG"}, {"family": "Danchev", "given": "Valentin", "initials": "V"}, {"family": "Dirnagl", "given": "Ulrich", "initials": "U"}, {"family": "Ewald", "given": "Hannah", "initials": "H"}, {"family": "Gartlehner", "given": "Gerald", "initials": "G"}, {"family": "Goodman", "given": "Steven N", "initials": "SN"}, {"family": "Haber", "given": "Noah A", "initials": "NA"}, {"family": "Ioannidis", "given": "Angeliki Diotima", "initials": "AD"}, {"family": "Ioannidis", "given": "John P A", "initials": "JPA"}, {"family": "Lythgoe", "given": "Mark P", "initials": "MP"}, {"family": "Ma", "given": "Wenyan", "initials": "W"}, {"family": "Macleod", "given": "Malcolm", "initials": "M"}, {"family": "Mali\u010dki", "given": "Mario", "initials": "M"}, {"family": "Meerpohl", "given": "Joerg J", "initials": "JJ"}, {"family": "Min", "given": "Yan", "initials": "Y"}, {"family": "Moher", "given": "David", "initials": "D"}, {"family": "Nagavci", "given": "Blin", "initials": "B"}, {"family": "Naudet", "given": "Florian", "initials": "F"}, {"family": "Pauli-Magnus", "given": "Christiane", "initials": "C"}, {"family": "O'Sullivan", "given": "Jack W", "initials": "JW"}, {"family": "Riedel", "given": "Nico", "initials": "N"}, {"family": "Roth", "given": "Jan A", "initials": "JA"}, {"family": "Sauermann", "given": "Mandy", "initials": "M"}, {"family": "Schandelmaier", "given": "Stefan", "initials": "S"}, {"family": "Schmitt", "given": "Andreas M", "initials": "AM"}, {"family": "Speich", "given": "Benjamin", "initials": "B"}, {"family": "Williamson", "given": "Paula R", "initials": "PR"}, {"family": "Hemkens", "given": "Lars G", "initials": "LG"}], "type": "journal article", "published": "2020-10-02", "journal": {"title": "F1000Res", "issn": "2046-1402", "issn-l": "2046-1402", "volume": "9", "issue": null, "pages": "1193"}, "abstract": "Background: Never before have clinical trials drawn as much public attention as those testing interventions for COVID-19. We aimed to describe the worldwide COVID-19 clinical research response and its evolution over the first 100 days of the pandemic. Methods: Descriptive analysis of planned, ongoing or completed trials by April 9, 2020 testing any intervention to treat or prevent COVID-19, systematically identified in trial registries, preprint servers, and literature databases. A survey was conducted of all trials to assess their recruitment status up to July 6, 2020. Results: Most of the 689 trials (overall target sample size 396,366) were small (median sample size 120; interquartile range [IQR] 60-300) but randomized (75.8%; n=522) and were often conducted in China (51.1%; n=352) or the USA (11%; n=76). 525 trials (76.2%) planned to include 155,571 hospitalized patients, and 25 (3.6%) planned to include 96,821 health-care workers. Treatments were evaluated in 607 trials (88.1%), frequently antivirals (n=144) or antimalarials (n=112); 78 trials (11.3%) focused on prevention, including 14 vaccine trials. No trial investigated social distancing. Interventions tested in 11 trials with >5,000 participants were also tested in 169 smaller trials (median sample size 273; IQR 90-700). Hydroxychloroquine alone was investigated in 110 trials. While 414 trials (60.0%) expected completion in 2020, only 35 trials (4.1%; 3,071 participants) were completed by July 6. Of 112 trials with detailed recruitment information, 55 had recruited <20% of the targeted sample; 27 between 20-50%; and 30 over 50% (median 14.8% [IQR 2.0-62.0%]). Conclusions: The size and speed of the COVID-19 clinical trials agenda is unprecedented. However, most trials were small investigating a small fraction of treatment options. The feasibility of this research agenda is questionable, and many trials may end in futility, wasting research resources. Much better coordination is needed to respond to global health threats.", "doi": "10.12688/f1000research.26707.2", "pmid": "33082937", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7539080.2"}], "notes": [], "created": "2020-11-19T19:33:08.731Z", "modified": "2022-11-09T09:01:59.475Z"}, {"entity": "publication", "iuid": "0b339525d3774ee0bbe33c3f9eb82687", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b339525d3774ee0bbe33c3f9eb82687.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b339525d3774ee0bbe33c3f9eb82687"}}, "title": "The COVID-19 outbreak and approaches to performing EEG in Europe.", "authors": [{"family": "Krysl", "given": "David", "initials": "D"}, {"family": "Beniczky", "given": "S\u00e1ndor", "initials": "S"}, {"family": "Franceschetti", "given": "Silvana", "initials": "S"}, {"family": "Arzimanoglou", "given": "Alexis", "initials": "A"}], "type": "journal article", "published": "2020-10-01", "journal": {"title": "Epileptic Disord", "issn": "1950-6945", "issn-l": null, "volume": "22", "issue": "5", "pages": "548-554"}, "abstract": "The coronavirus SARS-CoV-2 disease (COVID-19) pandemic affects availability and performance of neurophysiological diagnostic methods, including EEG. Our objective was to outline the current situation regarding EEG-based investigations across Europe. A web-based survey was distributed to centres within the European Reference Network on rare and complex epilepsies (ERN EpiCARE). Responses were collected between April 9 and May 15, 2020. Results were analysed with Microsoft Excel, Python Pandas and SciPy. Representants from 47 EpiCARE centres from 22 countries completed the survey. At the time of completing the survey, inpatient video-EEGs had been stopped or restricted in most centres (61.7% vs. 36.2% for adults, and 38.3% vs. 53.2% for children). Invasive investigations and epilepsy surgery were similarly affected. Acute EEGs continued to be performed, while indications for outpatient EEGs were limited and COVID-19 triage put in place. The strictness of measures varied according to extent of the outbreak in a given country. The results indicate a profound impact of COVID-19 on neurophysiological diagnostics, especially inpatient video-EEGs, invasive investigations, and epilepsy surgery. The COVID-19 pandemic may hamper care for patients in need of EEG-based investigations, particularly patients with seizure disorders. ERN EpiCARE will work on recommendations on how to rapidly adapt to such situations in order to alleviate consequences for our patients.", "doi": "10.1684/epd.2020.1208", "pmid": "33095171", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "epd.2020.1208"}], "notes": [], "created": "2020-12-01T15:35:43.413Z", "modified": "2021-02-26T08:46:12.902Z"}, {"entity": "publication", "iuid": "3714d5962dfe4aa4bed16288c686fa97", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3714d5962dfe4aa4bed16288c686fa97.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3714d5962dfe4aa4bed16288c686fa97"}}, "title": "Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19.", "authors": [{"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "Perez-Potti", "given": "Andr\u00e9", "initials": "A"}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Gorin", "given": "Jean-Baptiste", "initials": "J"}, {"family": "Olsson", "given": "Annika", "initials": "A"}, {"family": "Llewellyn-Lacey", "given": "Sian", "initials": "S"}, {"family": "Kamal", "given": "Habiba", "initials": "H"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Wullimann", "given": "David J", "initials": "DJ"}, {"family": "Kammann", "given": "Tobias", "initials": "T"}, {"family": "Emg\u00e5rd", "given": "Johanna", "initials": "J"}, {"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Folkesson", "given": "Elin", "initials": "E"}, {"family": "Karolinska COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Henter", "given": "Jan-Inge", "initials": "J"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Allander", "given": "Tobias", "initials": "T"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Nielsen", "given": "Morten", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Price", "given": "David A", "initials": "DA"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}], "type": "journal article", "published": "2020-10-01", "journal": {"title": "Cell", "issn": "1097-4172", "issn-l": "0092-8674", "volume": "183", "issue": "1", "pages": "158-168.e14"}, "abstract": "SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.", "doi": "10.1016/j.cell.2020.08.017", "pmid": "32979941", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Genomics & transcriptomics": null, "Category: Other": null, "Category: Proteins": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.1016/j.cell.2020.08.017", "description": "Supplementary materials: predicted binding affinities, donor characteristics, sample information, and some analyses"}, {"db": "NA", "key": "All data included in the paper", "description": null}], "notes": [], "created": "2020-10-28T09:03:34.190Z", "modified": "2021-11-18T09:21:57.000Z"}, {"entity": "publication", "iuid": "ea5eacb93e4747ee98374542036f42a9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ea5eacb93e4747ee98374542036f42a9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ea5eacb93e4747ee98374542036f42a9"}}, "title": "Nitric oxide dosed in short bursts at high concentrations may protect against Covid 19.", "authors": [{"family": "Hedenstierna", "given": "G\u00f6ran", "initials": "G"}, {"family": "Chen", "given": "Luni", "initials": "L"}, {"family": "Hedenstierna", "given": "Magnus", "initials": "M"}, {"family": "Lieberman", "given": "Robert", "initials": "R"}, {"family": "Fine", "given": "David H", "initials": "DH"}], "type": "journal article", "published": "2020-10-01", "journal": {"title": "Nitric Oxide", "issn": "1089-8611", "issn-l": "1089-8603", "volume": "103", "issue": null, "pages": "1-3"}, "abstract": "It has long been suggested that NO may inhibit an early stage in viral replication. Furthermore, in vitro tests have shown that NO inhibits the replication cycle of severe acute respiratory syndrome coronavirus. Despite smoking being listed as a risk factor to contract Covid-19, only a low proportion of the smokers suffered from SARS-corona infection in China 2003, and from Covid-19 in China, Europe and the US. We hypothesize, that the intermittent bursts of high NO concentration in cigarette smoke may be a mechanism in protecting against the virus. Mainstream smoke from cigarettes contains NO at peak concentrations of between about 250 ppm and 1350 ppm in each puff as compared to medicinal use of no more than 80 to a maximum of 160 ppm. The diffusion of NO through the cell wall to reach the virus should be significantly more effective at the very high NO concentration in the smoke, according to classic laws of physics. The only oxide of nitrogen in the mainstream smoke is NO, and the NO 2 concentration that is inhaled is very low or undetectable, and methemoglobin levels are lower in smokers than non-smokers, reasonably explained by the breaths of air in between the puffs that wash out the NO. Specialized iNO machines can now be developed to provide the drug intermittently in short bursts at high concentration dose, which would then provide both a preventative drug for those at high risk, as well as an effective treatment, without the health hazards associated with smoking.", "doi": "10.1016/j.niox.2020.06.005", "pmid": "32590117", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1089-8603(20)30161-0"}], "notes": [], "created": "2020-11-18T17:31:13.966Z", "modified": "2022-11-09T09:05:12.512Z"}, {"entity": "publication", "iuid": "8adbd429360c459896c97d05c262fe58", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8adbd429360c459896c97d05c262fe58.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8adbd429360c459896c97d05c262fe58"}}, "title": "Injuries From Asymptomatic COVID-19 Disease: New Hidden Toxicity Risk Factors in Thoracic Radiation Therapy.", "authors": [{"family": "Cella", "given": "Laura", "initials": "L"}, {"family": "Gagliardi", "given": "Giovanna", "initials": "G"}, {"family": "Hedman", "given": "Mattias", "initials": "M"}, {"family": "Palma", "given": "Giuseppe", "initials": "G"}], "type": "editorial", "published": "2020-10-01", "journal": {"title": "Int J Radiat Oncol Biol Phys", "issn": "1879-355X", "volume": "108", "issue": "2", "pages": "394-396", "issn-l": null}, "abstract": null, "doi": "10.1016/j.ijrobp.2020.06.055", "pmid": "32890518", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0360-3016(20)31342-0"}, {"db": "pmc", "key": "PMC7462877"}], "notes": [], "created": "2020-12-06T07:23:44.506Z", "modified": "2020-12-06T07:24:52.091Z"}, {"entity": "publication", "iuid": "e6a43c1c7bad40cc931b0b4b61b9ae1a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e6a43c1c7bad40cc931b0b4b61b9ae1a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e6a43c1c7bad40cc931b0b4b61b9ae1a"}}, "title": "In search of the relevant COVID research", "authors": [{"family": "Allebeck", "given": "Peter", "initials": "P", "orcid": "0000-0002-2778-6467", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/de9f0e1c3e4d402b93e61ad1c5a771fb.json"}}, {"family": "S\u00f6rberg Wallin", "given": "Alma", "initials": "A", "orcid": "0000-0002-8804-095X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bdaa3ba8e9c149a6b4c05d924f31d0e5.json"}}], "type": "journal-article", "published": "2020-10-01", "journal": {"title": "Eur J Public Health", "issn": "1101-1262", "volume": "30", "issue": "5", "pages": "850-851", "issn-l": null}, "abstract": null, "doi": "10.1093/eurpub/ckaa169", "pmid": "32818271", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7536247"}, {"db": "pii", "key": "5894973"}], "notes": [], "created": "2020-12-07T12:24:48.738Z", "modified": "2023-06-19T07:32:18.110Z"}, {"entity": "publication", "iuid": "bf3c55cfd0094f7f84d20a9e3b1a934b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bf3c55cfd0094f7f84d20a9e3b1a934b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bf3c55cfd0094f7f84d20a9e3b1a934b"}}, "title": "Extracorporeal membrane oxygenation in children with COVID-19: Preliminary report from the collaborative EuroELSO prospective survey.", "authors": [{"family": "Di Nardo", "given": "M", "initials": "M"}, {"family": "Hoskote", "given": "A", "initials": "A"}, {"family": "Thiruchelvam", "given": "T", "initials": "T"}, {"family": "Lillie", "given": "J", "initials": "J"}, {"family": "Horan", "given": "M", "initials": "M"}, {"family": "Belda Hofheinz", "given": "S", "initials": "S"}, {"family": "Dupic", "given": "L", "initials": "L"}, {"family": "Gimeno", "given": "R", "initials": "R"}, {"family": "De Piero", "given": "M E", "initials": "ME"}, {"family": "Lo Coco", "given": "V", "initials": "V"}, {"family": "Roeleveld", "given": "P", "initials": "P"}, {"family": "Davidson", "given": "M", "initials": "M"}, {"family": "Jones", "given": "T", "initials": "T"}, {"family": "Broman", "given": "L M", "initials": "LM"}, {"family": "Lorusso", "given": "R", "initials": "R"}, {"family": "Belohlavek", "given": "J", "initials": "J"}, {"family": "EuroELSO Neonatal & Pediatric Working Group & collaborators on COVID-19", "given": "", "initials": ""}], "type": "journal article", "published": "2020-10-01", "journal": {"title": "ASAIO J", "issn": "1538-943X", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Perspective", "doi": "10.1097/MAT.0000000000001309", "pmid": "33009172", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-03T08:58:24.297Z", "modified": "2020-12-03T08:59:18.873Z"}, {"entity": "publication", "iuid": "87d2e0c1a45746429254b6b2c9d5c732", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87d2e0c1a45746429254b6b2c9d5c732.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87d2e0c1a45746429254b6b2c9d5c732"}}, "title": "Exploring views and experiences of how infections are detected and managed in practice by nurses, care workers and manager's in nursing homes in England and Sweden: a survey protocol.", "authors": [{"family": "Carey", "given": "N", "initials": "N"}, {"family": "Alkhamees", "given": "Nouf", "initials": "N"}, {"family": "Cox", "given": "Anna", "initials": "A"}, {"family": "Sund-Levander", "given": "Marta", "initials": "M"}, {"family": "Tingstr\u00f6m", "given": "Pia", "initials": "P"}, {"family": "Mold", "given": "Freda", "initials": "F"}], "type": "journal article", "published": "2020-10-01", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "10", "issue": "10", "pages": "e038390"}, "abstract": "In order to avoid unnecessary hospital admission and associated complications, there is an urgent need to improve the early detection of infection in nursing home residents. Monitoring signs and symptoms with checklists or aids called decision support tools may help nursing home staff to detect infection in residents, particularly during the current COVID-19 pandemic.We plan to conduct a survey exploring views and experiences of how infections are detected and managed in practice by nurses, care workers and managers in nursing homes in England and Sweden.\r\n\r\nAn international cross-sectional descriptive survey, using a pretested questionnaire, will be used to explore nurses, care workers and managers views and experiences of how infections are detected and managed in practice in nursing homes. Data will be analysed descriptively and univariate associations between personal and organisational factors explored. This will help identify important factors related to awareness, knowledge, attitudes, belief and skills likely to affect future implementation of a decision support tool for the early detection of infection in nursing home residents.\r\n\r\nThis study was approved using the self-certification process at the University of Surrey and Link\u00f6ping University ethics committee (Approval 2018/514-32) in 2018. Study findings will be disseminated through community/stakeholder/service user engagement events in each country, publication in academic peer-reviewed journals and conference presentations. A LAY summary will be provided to participants who indicate they would like to receive this information.This is the first stage of a plan of work to revise and evaluate the Early Detection of Infection Scale (EDIS) tool and its effect on managing infections and reducing unplanned hospital admissions in nursing home residents. Implementation of the EDIS tool may have important implications for the healthcare economy; this will be explored in cost-benefit analyses as the work progresses.", "doi": "10.1136/bmjopen-2020-038390", "pmid": "33004397", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-038390"}, {"db": "pmc", "key": "PMC7534694"}], "notes": [], "created": "2020-12-03T08:59:56.608Z", "modified": "2022-11-09T09:06:09.469Z"}, {"entity": "publication", "iuid": "41ec42fe6a674cf0bebd830f2d7ed408", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41ec42fe6a674cf0bebd830f2d7ed408.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41ec42fe6a674cf0bebd830f2d7ed408"}}, "title": "Early lessons from COVID-19 response and shifts in authority: public trust, policy legitimacy and political inclusion.", "authors": [{"family": "Bekker", "given": "Marleen", "initials": "M"}, {"family": "Ivankovic", "given": "Damir", "initials": "D"}, {"family": "Biermann", "given": "Olivia", "initials": "O"}], "type": "journal article", "published": "2020-10-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "volume": "30", "issue": "5", "pages": "854-855", "issn-l": "1101-1262"}, "abstract": null, "doi": "10.1093/eurpub/ckaa181", "pmid": "33020828", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "5918171"}, {"db": "pmc", "key": "PMC7665464"}], "notes": [], "created": "2020-12-01T18:17:21.351Z", "modified": "2020-12-01T18:17:45.967Z"}, {"entity": "publication", "iuid": "c8d295439f1242699d9db621b035dca5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c8d295439f1242699d9db621b035dca5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c8d295439f1242699d9db621b035dca5"}}, "title": "Coping behaviors associated with decreased anxiety and depressive symptoms during the COVID-19 pandemic and lockdown.", "authors": [{"family": "Fullana", "given": "Miquel A", "initials": "MA"}, {"family": "Hidalgo-Mazzei", "given": "Diego", "initials": "D"}, {"family": "Vieta", "given": "Eduard", "initials": "E"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}], "type": "letter", "published": "2020-10-01", "journal": {"title": "J Affect Disord", "issn": "1573-2517", "issn-l": null, "volume": "275", "issue": null, "pages": "80-81"}, "abstract": "The COVID-19 pandemic and lockdown might increase anxiety and depressive symptoms, but some behaviors may protect against them.\r\n\r\nTo provide a preliminary evidence of the behaviors associated with decreased symptoms in the current COVID-19 pandemic and lockdown, we conducted a survey of 5545 adult individuals from the Spanish general population, two weeks after an official lockdown was established across the country.\r\n\r\nSixty-five percent of the sample reported anxiety or depressive symptoms. Following a healthy/balanced diet and not reading news/updates about COVID-19 very often were the best predictors of lower levels of anxiety symptoms. Following a healthy/balanced diet, following a routine, not reading news/updates about COVID-19 very often, taking the opportunity to pursue hobbies, and staying outdoors or looking outside were the best predictors of lower levels of depressive symptoms.\r\n\r\nCross-sectional nature and use of sample of convenience.\r\n\r\nThis study suggests that \"simple\" coping behaviors may protect against anxiety and depressive symptoms during the COVID-19 pandemic and lockdown.", "doi": "10.1016/j.jad.2020.06.027", "pmid": "32658829", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0165-0327(20)32385-5"}, {"db": "pmc", "key": "PMC7329680"}], "notes": [], "created": "2020-12-08T14:12:49.935Z", "modified": "2022-11-09T09:07:06.608Z"}, {"entity": "publication", "iuid": "39063093dd1344619fa982e652ac2867", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/39063093dd1344619fa982e652ac2867.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/39063093dd1344619fa982e652ac2867"}}, "title": "What will the long-lasting effect of the COVID-19 pandemic be on children's health and wellbeing?", "authors": [{"family": "Alfv\u00e9n", "given": "Tobias", "initials": "T"}], "type": "editorial", "published": "2020-10-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": "109", "issue": "10", "pages": "1924-1925"}, "abstract": "Editorial", "doi": "10.1111/apa.15513", "pmid": "32870545", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-07T07:48:22.434Z", "modified": "2020-12-07T07:48:47.205Z"}, {"entity": "publication", "iuid": "3110e37d5cb6405fa6a57bb42975d2ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3110e37d5cb6405fa6a57bb42975d2ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3110e37d5cb6405fa6a57bb42975d2ca"}}, "title": "What to expect for the influenza season 2020/21 with the ongoing COVID-19 pandemic in the World Health Organization European Region.", "authors": [{"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Pebody", "given": "Richard", "initials": "R"}], "type": "editorial", "published": "2020-10-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "25", "issue": "42", "pages": null}, "abstract": "Editorial", "doi": "10.2807/1560-7917.ES.2020.25.42.2001816", "pmid": "33094719", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7651872"}], "notes": [], "created": "2020-12-01T15:36:42.114Z", "modified": "2020-12-11T12:47:41.046Z"}, {"entity": "publication", "iuid": "abdab7a0dd85434b9d24eb8a689e7e6f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abdab7a0dd85434b9d24eb8a689e7e6f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abdab7a0dd85434b9d24eb8a689e7e6f"}}, "title": "Unraveling the Immune Response in Severe COVID-19", "authors": [{"family": "Rodriguez", "given": "Lucie", "initials": "L"}, {"family": "Brodin", "given": "Petter", "initials": "P"}], "type": "journal-article", "published": "2020-10-00", "journal": {"title": "J Clin Immunol", "issn": "0271-9142", "issn-l": null, "volume": "40", "issue": "7", "pages": "958-959"}, "abstract": "Comment", "doi": "10.1007/s10875-020-00849-9", "pmid": "32827284", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-04T15:15:07.666Z", "modified": "2021-01-11T10:50:50.121Z"}, {"entity": "publication", "iuid": "d15ae52217704044b6357eda9c434dbb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d15ae52217704044b6357eda9c434dbb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d15ae52217704044b6357eda9c434dbb"}}, "title": "Treating patients with cancer amidst the COVID-19 pandemic: experience of a regional hospital in the Piedmont region in northern Italy", "authors": [{"family": "Garrone", "given": "Ornella", "initials": "O"}, {"family": "Denaro", "given": "Nerina", "initials": "N"}, {"family": "Ruatta", "given": "Fiorella", "initials": "F"}, {"family": "Vanella", "given": "Paola", "initials": "P"}, {"family": "Granetto", "given": "Cristina", "initials": "C"}, {"family": "Vandone", "given": "Anna Maria", "initials": "AM"}, {"family": "Occelli", "given": "Marcella", "initials": "M"}, {"family": "Cauchi", "given": "Carolina", "initials": "C"}, {"family": "Ricci", "given": "Vincenzo", "initials": "V"}, {"family": "Fea", "given": "Elena", "initials": "E"}, {"family": "Di Costanzo", "given": "Gianna", "initials": "G"}, {"family": "Colantonio", "given": "Ida", "initials": "I"}, {"family": "Crosetto", "given": "Nicola", "initials": "N"}, {"family": "Merlano", "given": "Marco C", "initials": "MC"}], "type": "journal-article", "published": "2020-10-00", "journal": {"title": "Tumori", "issn": "0300-8916", "issn-l": null, "volume": "106", "issue": "5", "pages": "427-431"}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic is posing an unprecedented dilemma to oncologists worldwide, forcing them to decide whether to continue or suspend treatments in order to protect their most vulnerable patients from infection. After the first report from China, the outbreak spread rapidly worldwide. To, date no clear indications on how to treat patients with cancer with COVID-19 infection are available.\r\n\r\nWe report data on 21 patients with cancer referred to a single medical oncology unit of a general hospital from mid-March to April 23, 2020.\r\n\r\nNine patients were on active cancer therapy during the infection and all stopped medical treatments. Overall 8 patients developed pneumonia and 6 patients died of COVID-19.\r\n\r\nThe management of patients with cancer during the pandemic should be carefully balanced and discussed among oncologists and other key professionals involved in the treatment of this vulnerable group of patients, in order to balance the risk of treatment and the risk of infection.", "doi": "10.1177/0300891620942313", "pmid": "32703089", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Serology": null}, "xrefs": [], "notes": [], "created": "2020-11-04T16:12:10.666Z", "modified": "2021-02-26T08:46:49.391Z"}, {"entity": "publication", "iuid": "2e208a260070478a86af9d6ad8e3bcf3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e208a260070478a86af9d6ad8e3bcf3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e208a260070478a86af9d6ad8e3bcf3"}}, "title": "Tracking Potential COVID-19 Outbreaks With Influenzalike Symptoms Urgent Care Visits.", "authors": [{"family": "Muchmore", "given": "Brian", "initials": "B"}, {"family": "Muchmore", "given": "Patrick", "initials": "P"}, {"family": "Lee", "given": "Chi Wing", "initials": "CW"}, {"family": "Alarc\u00f3n-Riquelme", "given": "Marta E", "initials": "ME"}, {"family": "Muchmore", "given": "Andrew", "initials": "A"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Pediatrics", "issn": "1098-4275", "volume": "146", "issue": "4", "issn-l": null}, "abstract": null, "doi": "10.1542/peds.2020-1798", "pmid": "32699069", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "peds.2020-1798"}], "notes": [], "created": "2020-12-07T16:23:06.401Z", "modified": "2020-12-07T16:23:29.349Z"}, {"entity": "publication", "iuid": "e42a35963dbb42b3bf0375853434ff79", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e42a35963dbb42b3bf0375853434ff79.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e42a35963dbb42b3bf0375853434ff79"}}, "title": "The scope of mental health research during the COVID-19 pandemic and its aftermath.", "authors": [{"family": "Hotopf", "given": "Matthew", "initials": "M"}, {"family": "Bullmore", "given": "Ed", "initials": "E"}, {"family": "O'Connor", "given": "Rory C", "initials": "RC"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Br J Psychiatry", "issn": "1472-1465", "volume": "217", "issue": "4", "pages": "540-542", "issn-l": "0007-1250"}, "abstract": "The effects of the COVID-19 pandemic on population mental health are unknown. We need to understand the scale of any such impact in different sections of the population, who is most affected and how best to mitigate, prevent and treat any excess morbidity. We propose a coordinated and interdisciplinary mental health science response.", "doi": "10.1192/bjp.2020.125", "pmid": "32493516", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0007125020001257"}, {"db": "pmc", "key": "PMC7330278"}], "notes": [], "created": "2020-11-19T19:24:00.166Z", "modified": "2020-12-09T10:49:57.015Z"}, {"entity": "publication", "iuid": "57349b4780174ff1a804f9c0301aee0d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/57349b4780174ff1a804f9c0301aee0d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/57349b4780174ff1a804f9c0301aee0d"}}, "title": "The mediating effect of the cyberchondria and anxiety sensitivity in the association between problematic internet use, metacognition beliefs, and fear of COVID-19 among Iranian online population.", "authors": [{"family": "Seyed Hashemi", "given": "Seyed Ghasem", "initials": "SG"}, {"family": "Hosseinnezhad", "given": "Shalaleh", "initials": "S"}, {"family": "Dini", "given": "Solmaz", "initials": "S"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Heliyon", "issn": "2405-8440", "issn-l": null, "volume": "6", "issue": "10", "pages": "e05135"}, "abstract": "With the rapid growth of the novel coronavirus disease 2019 (COVID-19), individuals may try to find related medical information using the internet to overcome their fears. Under such circumstances, individuals with the features of cyberchondria, anxiety sensitivity, and metacognitive beliefs in negative thoughts may suffer more fears than those without these features. Therefore, the present study proposed a model to understand the associations between problematic internet use (PIU), cyberchondria, anxiety sensitivity, metacognition beliefs, and fear of COVID-19. Utilizing a cross-sectional online survey, 651 Iranians completed the following psychometric scales: Metacognition Questionnaire-30 (MCQ-30), Anxiety Sensitivity Questionnaire (ASI), Cyberchondria Severity Scale-Short Form (CSS-12), Fear of COVID-19 Scale (FCV-19S), and Generalized Problematic Internet Use Scale (GPIUS). Structural equation modeling (SEM) was used to assess the proposed model via several fit indices. The indices include Tucker-Lewis index (TLI), comparative fit index (CFI), standardized root mean square residual (SRMR), and root mean square error of approximation (RMSEA). The fit indices (CFI = 0.948, TLI = 0.938, RMSEA = 0.053, and SRMR = 0.001) indicated the good fit between the data and the proposed model. Moreover, fear of COVID-19 was significantly and directly predicted by cyberchondria (\u03b2 = 0.479, p < .001) and anxiety sensitivity (\u03b2 = 0.286, p < .001). The relationship between PIU and cyberchondria with fear of COVID-19 was mediated significantly by anxiety sensitivity and metacognitive beliefs. Because fear of COVID-19 was found to be significantly associated with cyberchondria and anxiety sensitivity, healthcare providers may want to provide additional support for those with cyberchondria and anxiety sensitivity tendencies.", "doi": "10.1016/j.heliyon.2020.e05135", "pmid": "33072911", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2405-8440(20)31978-2"}, {"db": "pmc", "key": "PMC7547399"}], "notes": [], "created": "2020-12-01T17:02:50.671Z", "modified": "2022-11-09T09:08:08.956Z"}, {"entity": "publication", "iuid": "53e0c79e38674500b109629509265e6e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53e0c79e38674500b109629509265e6e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53e0c79e38674500b109629509265e6e"}}, "title": "The impact of COVID-19 on research.", "authors": [{"family": "Harper", "given": "L", "initials": "L"}, {"family": "Kalfa", "given": "N", "initials": "N"}, {"family": "Beckers", "given": "G M A", "initials": "GMA"}, {"family": "Kaefer", "given": "M", "initials": "M"}, {"family": "Nieuwhof-Leppink", "given": "A J", "initials": "AJ"}, {"family": "Fossum", "given": "Magdalena", "initials": "M"}, {"family": "Herbst", "given": "K W", "initials": "KW"}, {"family": "Bagli", "given": "D", "initials": "D"}, {"family": "ESPU Research Committee", "given": "", "initials": ""}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "J Pediatr Urol", "issn": "1873-4898", "volume": "16", "issue": "5", "pages": "715-716", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jpurol.2020.07.002", "pmid": "32713792", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1477-5131(20)30412-5"}, {"db": "pmc", "key": "PMC7343645"}], "notes": [], "created": "2020-12-07T16:13:37.865Z", "modified": "2020-12-07T16:13:37.891Z"}, {"entity": "publication", "iuid": "00fdf422a3cd461bb84a16cfec56bc74", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/00fdf422a3cd461bb84a16cfec56bc74.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/00fdf422a3cd461bb84a16cfec56bc74"}}, "title": "The impact of COVID-19 on contraception and abortion care policy and practice: experiences from selected countries.", "authors": [{"family": "Bateson", "given": "Deborah J", "initials": "DJ"}, {"family": "Lohr", "given": "Patricia A", "initials": "PA"}, {"family": "Norman", "given": "Wendy V", "initials": "WV"}, {"family": "Moreau", "given": "Caroline", "initials": "C"}, {"family": "Gemzell-Danielsson", "given": "Kristina", "initials": "K"}, {"family": "Blumenthal", "given": "Paul D", "initials": "PD"}, {"family": "Hoggart", "given": "Lesley", "initials": "L"}, {"family": "Li", "given": "Hang-Wun Raymond", "initials": "HR"}, {"family": "Aiken", "given": "Abigail R A", "initials": "ARA"}, {"family": "Black", "given": "Kirsten I", "initials": "KI"}], "type": "editorial", "published": "2020-10-00", "journal": {"title": "BMJ Sex Reprod Health", "issn": "2515-2009", "issn-l": "2515-1991", "volume": "46", "issue": "4", "pages": "241-243"}, "abstract": null, "doi": "10.1136/bmjsrh-2020-200709", "pmid": "32788180", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "bmjsrh-2020-200709"}], "notes": [], "created": "2020-12-07T13:28:03.197Z", "modified": "2021-02-26T08:46:59.783Z"}, {"entity": "publication", "iuid": "772a3dbc1c954feda18fa8b7a7f68aaa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/772a3dbc1c954feda18fa8b7a7f68aaa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/772a3dbc1c954feda18fa8b7a7f68aaa"}}, "title": "The immuno-oncological challenge of COVID-19.", "authors": [{"family": "Derosa", "given": "Lisa", "initials": "L"}, {"family": "Melenotte", "given": "Cl\u00e9a", "initials": "C"}, {"family": "Griscelli", "given": "Franck", "initials": "F"}, {"family": "Gachot", "given": "Bertrand", "initials": "B"}, {"family": "Marabelle", "given": "Aur\u00e9lien", "initials": "A"}, {"family": "Kroemer", "given": "Guido", "initials": "G", "orcid": "0000-0002-9334-4405", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d17de2122d0429eaa48a733bf2ad28e.json"}}, {"family": "Zitvogel", "given": "Laurence", "initials": "L", "orcid": "0000-0003-1596-0998", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b10947c1a2b4884b3f502625a28c5e0.json"}}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Nat Cancer", "issn": "2662-1347", "volume": "1", "issue": "10", "pages": "946-964", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) and its causative virus, SARS-CoV-2, pose considerable challenges for the management of oncology patients. COVID-19 presents as a particularly severe respiratory and systemic infection in aging and immunosuppressed individuals, including patients with cancer. Moreover, severe COVID-19 is linked to an inflammatory burst and lymphopenia, which may aggravate cancer prognosis. Here we discuss why those with cancer are at higher risk of severe COVID-19, describe immune responses that confer protective or adverse reactions to this disease and indicate which antineoplastic therapies may either increase COVID-19 vulnerability or have a dual therapeutic effect on cancer and COVID-19.", "doi": "10.1038/s43018-020-00122-3", "pmid": "35121872", "labels": {"Type: Other": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s43018-020-00122-3"}], "notes": [], "created": "2023-01-13T13:38:05.320Z", "modified": "2023-01-13T13:38:05.345Z"}, {"entity": "publication", "iuid": "28cd389d36e14115adf57031c5a35ffe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/28cd389d36e14115adf57031c5a35ffe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/28cd389d36e14115adf57031c5a35ffe"}}, "title": "The Post COVID-19 Surgical Backlog: Now is the Time to Implement Enhanced Recovery After Surgery (ERAS).", "authors": [{"family": "Ljungqvist", "given": "Olle", "initials": "O"}, {"family": "Nelson", "given": "Gregg", "initials": "G"}, {"family": "Demartines", "given": "Nicolas", "initials": "N"}], "type": "editorial", "published": "2020-10-00", "journal": {"title": "World J Surg", "issn": "1432-2323", "volume": "44", "issue": "10", "pages": "3197-3198", "issn-l": null}, "abstract": null, "doi": "10.1007/s00268-020-05734-5", "pmid": "32803298", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00268-020-05734-5"}, {"db": "pmc", "key": "PMC7427753"}], "notes": [], "created": "2020-12-07T13:21:01.304Z", "modified": "2020-12-07T13:21:34.806Z"}, {"entity": "publication", "iuid": "6a70ee06a5b64d49858744269591ecf7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6a70ee06a5b64d49858744269591ecf7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6a70ee06a5b64d49858744269591ecf7"}}, "title": "Symptoms of a broken system: the gender gaps in COVID-19 decision-making.", "authors": [{"family": "van Daalen", "given": "Kim Robin", "initials": "KR"}, {"family": "Bajnoczki", "given": "Csongor", "initials": "C"}, {"family": "Chowdhury", "given": "Maisoon", "initials": "M"}, {"family": "Dada", "given": "Sara", "initials": "S"}, {"family": "Khorsand", "given": "Parnian", "initials": "P"}, {"family": "Socha", "given": "Anna", "initials": "A"}, {"family": "Lal", "given": "Arush", "initials": "A"}, {"family": "Jung", "given": "Laura", "initials": "L"}, {"family": "Alqodmani", "given": "Lujain", "initials": "L"}, {"family": "Torres", "given": "Irene", "initials": "I"}, {"family": "Ouedraogo", "given": "Samiratou", "initials": "S"}, {"family": "Mahmud", "given": "Amina Jama", "initials": "AJ"}, {"family": "Dhatt", "given": "Roopa", "initials": "R"}, {"family": "Phelan", "given": "Alexandra", "initials": "A"}, {"family": "Rajan", "given": "Dheepa", "initials": "D"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "5", "issue": "10", "pages": null, "issn-l": "2059-7908"}, "abstract": "Commentary", "doi": "10.1136/bmjgh-2020-003549", "pmid": "33004348", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-003549"}, {"db": "pmc", "key": "PMC7533958"}], "notes": [], "created": "2020-11-22T08:50:53.440Z", "modified": "2020-12-03T09:00:30.143Z"}, {"entity": "publication", "iuid": "3c717a035dbb4f3099e07a2a3beb9de5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3c717a035dbb4f3099e07a2a3beb9de5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3c717a035dbb4f3099e07a2a3beb9de5"}}, "title": "Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population.", "authors": [{"family": "Ciabattini", "given": "Annalisa", "initials": "A"}, {"family": "Garagnani", "given": "Paolo", "initials": "P"}, {"family": "Santoro", "given": "Francesco", "initials": "F"}, {"family": "Rappuoli", "given": "Rino", "initials": "R"}, {"family": "Franceschi", "given": "Claudio", "initials": "C"}, {"family": "Medaglini", "given": "Donata", "initials": "D"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Semin Immunopathol", "issn": "1863-2300", "volume": "42", "issue": "5", "pages": "619-634", "issn-l": "1863-2297"}, "abstract": "The SARS-CoV-2 pandemic urgently calls for the development of effective preventive tools. COVID-19 hits greatly the elder and more fragile fraction of the population boosting the evergreen issue of the vaccination of older people. The development of a vaccine against SARS-CoV-2 tailored for the elderly population faces the challenge of the poor immune responsiveness of the older population due to immunosenescence, comorbidities, and pharmacological treatments. Moreover, it is likely that the inflammaging phenotype associated with age could both influence vaccination efficacy and exacerbate the risk of COVID-19-related \"cytokine storm syndrome\" with an overlap between the factors which impact vaccination effectiveness and those that boost virulence and worsen the prognosis of SARS-CoV-2 infection. The complex and still unclear immunopathological mechanisms of SARS-CoV-2 infection, together with the progressive age-related decline of immune responses, and the lack of clear correlates of protection, make the design of vaccination strategies for older people extremely challenging. In the ongoing effort in vaccine development, different SARS-CoV-2 vaccine candidates have been developed, tested in pre-clinical and clinical studies and are undergoing clinical testing, but only a small fraction of these are currently being tested in the older fraction of the population. Recent advances in systems biology integrating clinical, immunologic, and omics data can help to identify stable and robust markers of vaccine response and move towards a better understanding of SARS-CoV-2 vaccine responses in the elderly.", "doi": "10.1007/s00281-020-00821-0", "pmid": "33159214", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00281-020-00821-0"}, {"db": "pmc", "key": "PMC7646713"}], "notes": [], "created": "2020-11-26T12:26:46.196Z", "modified": "2020-11-27T10:08:00.584Z"}, {"entity": "publication", "iuid": "0dec90693fd642e1a368638f5da7892b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0dec90693fd642e1a368638f5da7892b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0dec90693fd642e1a368638f5da7892b"}}, "title": "Risks, resilience, and pathways to sustainable aviation: A COVID-19 perspective.", "authors": [{"family": "G\u00f6ssling", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "J Air Transp Manag", "issn": "1873-2089", "volume": "89", "issue": null, "pages": "101933", "issn-l": null}, "abstract": "This paper discusses the COVID-19 pandemic as an opportunity to reconsider the foundations of the global aviation system. There is much evidence that air transport creates opportunities as well as risks. While the former accrue to businesses and individuals, risks are imposed on society. Pandemics, in which aviation has a role as a vector of pathogen distribution, as well as the sector's contribution to climate change are examples of long-standing negative externalities that continue to be ignored in assessments of aviation's economic performance and societal importance. As commercial aviation has shown limited economic resilience throughout its history, this short paper questions whether a return to business-as-usual, supported by very significant State aid payments, is desirable. The volume growth model championed by industry and aviation proponents may have to be replaced with an alternative model of a slimmed air transport system that is economically less vulnerable and accounting for its environmental impacts.", "doi": "10.1016/j.jairtraman.2020.101933", "pmid": "32952322", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S0969-6997(20)30516-0"}, {"db": "pmc", "key": "PMC7492147"}], "notes": [], "created": "2020-12-03T09:33:48.678Z", "modified": "2020-12-03T09:33:48.703Z"}, {"entity": "publication", "iuid": "3fd62190ee1d459bbeb4b5f3eb01129c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3fd62190ee1d459bbeb4b5f3eb01129c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3fd62190ee1d459bbeb4b5f3eb01129c"}}, "title": "Returning to digestive endoscopy normality will be slow and must include novelty and telemedicine.", "authors": [{"family": "Koulaouzidis", "given": "Anastasios", "initials": "A"}, {"family": "Marlicz", "given": "Wojciech", "initials": "W"}, {"family": "Wenzek", "given": "Hagen", "initials": "H"}, {"family": "Koulaouzidis", "given": "George", "initials": "G"}, {"family": "Eliakim", "given": "Rami", "initials": "R"}, {"family": "Toth", "given": "Ervin", "initials": "E"}], "type": "letter", "published": "2020-10-00", "journal": {"title": "Dig Liver Dis", "issn": "1878-3562", "volume": "52", "issue": "10", "pages": "1099-1101", "issn-l": null}, "abstract": null, "doi": "10.1016/j.dld.2020.05.048", "pmid": "32571667", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1590-8658(20)30255-3"}, {"db": "pmc", "key": "PMC7304960"}], "notes": [], "created": "2020-12-08T16:28:21.367Z", "modified": "2020-12-08T16:28:21.390Z"}, {"entity": "publication", "iuid": "aace0e08aac84543b6d0633a82446ef2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aace0e08aac84543b6d0633a82446ef2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aace0e08aac84543b6d0633a82446ef2"}}, "title": "Pressure Optimized PowEred Respirator (PROPER): A miniaturized wearable cleanroom and biosafety system for aerially transmitted viral infections such as COVID-19.", "authors": [{"family": "Nazarious", "given": "Miracle Israel", "initials": "MI"}, {"family": "Mathanlal", "given": "Thasshwin", "initials": "T"}, {"family": "Zorzano", "given": "Maria-Paz", "initials": "MP"}, {"family": "Martin-Torres", "given": "Javier", "initials": "J"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "HardwareX", "issn": "2468-0672", "volume": "8", "issue": null, "pages": "e00144", "issn-l": null}, "abstract": "The supply of Personal Protective Equipment (PPE) in hospitals to keep the Health Care Professionals (HCP) safe taking care of patients may be limited, especially during the outbreak of a new disease. In particular, the face and body protective equipment is critical to prevent the wearer from exposure to pathogenic biological airborne particulates. This situation has been now observed worldwide during the onset of the COVID-19 pandemic. As concern over shortages of PPE at hospitals grows, we share with the public and makers' community the Pressure Optimized PowEred Respirator (PROPER) equipment, made out of COTS components. It is functionally equivalent to a Powered Air Purifying Respirator (PAPR). PROPER, a hood-based system which uses open source and easily accessible components is low-cost, relatively passive in terms of energy consumption and mechanisms, and easy and fast to 3D print, build and assemble. We have adapted our experience on building clean room environments and qualifying the bioburden of space instruments to this solution, which is in essence a miniaturized, personal, wearable cleanroom. PROPER would be able to offer better protection than an N95 respirator mask, mainly because it is insensitive to seal fit and it shields the eyes as well. The PROPER SMS fabric is designed for single-use and not intended for reuse, as they may start to tear and fail but the rest of the parts can be disinfected and reused. We provide a set of guidelines to build a low-cost 3D printed solution for an effective PAPR system and describe the procedures to validate it to comply with the biosafety level 3 requirements. We have validated the prototype of PROPER unit for air flow, ISO class cleanliness level, oxygen and carbon-dioxide gas concentrations during exhalation, and present here these results for illustration. We demonstrate that the area inside the hood is more than 200 times cleaner than the external ambient without the operator and more than 175 times with the operator and in an aerosol exposed environment. We also include the procedure to clean and disinfect the equipment for reuse. PROPER may be a useful addition to provide protection to HCPs against the SARS-CoV-2 virus or other potential future viral diseases that are transmitted aerially.", "doi": "10.1016/j.ohx.2020.e00144", "pmid": "33043172", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2468-0672(20)30053-5"}, {"db": "pmc", "key": "PMC7536593"}], "notes": [], "created": "2020-12-01T17:19:47.076Z", "modified": "2020-12-01T17:19:47.101Z"}, {"entity": "publication", "iuid": "7eac38cde76147eca0013d4c962fdd5e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7eac38cde76147eca0013d4c962fdd5e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7eac38cde76147eca0013d4c962fdd5e"}}, "title": "Physical activity during COVID-19 quarantine.", "authors": [{"family": "Shahidi", "given": "Seyed H", "initials": "SH"}, {"family": "Stewart Williams", "given": "Jennifer", "initials": "J"}, {"family": "Hassani", "given": "Fahimeh", "initials": "F"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": "109", "issue": "10", "pages": "2147-2148", "issn-l": "0803-5253"}, "abstract": null, "doi": "10.1111/apa.15420", "pmid": "32557827", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7323361"}], "notes": [], "created": "2020-12-09T07:45:52.698Z", "modified": "2020-12-09T07:46:00.446Z"}, {"entity": "publication", "iuid": "a6f02b3fa3814e92b4279055100a2c89", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a6f02b3fa3814e92b4279055100a2c89.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a6f02b3fa3814e92b4279055100a2c89"}}, "title": "Pediatric transplantation in Europe during the COVID-19 pandemic: Early impact on activity and healthcare.", "authors": [{"family": "Don\u00e1", "given": "Daniele", "initials": "D"}, {"family": "Torres Canizales", "given": "Juan", "initials": "J"}, {"family": "Benetti", "given": "Elisa", "initials": "E"}, {"family": "Cananzi", "given": "Mara", "initials": "M"}, {"family": "De Corti", "given": "Federica", "initials": "F"}, {"family": "Calore", "given": "Elisabetta", "initials": "E"}, {"family": "Hierro", "given": "Loreto", "initials": "L"}, {"family": "Ramos Boluda", "given": "Esther", "initials": "E"}, {"family": "Melgosa Hijosa", "given": "Marta", "initials": "M"}, {"family": "Garcia Guereta", "given": "Luis", "initials": "L"}, {"family": "P\u00e9rez Mart\u00ednez", "given": "Antonio", "initials": "A"}, {"family": "Barrios", "given": "Maribel", "initials": "M"}, {"family": "Costa Reis", "given": "Patricia", "initials": "P"}, {"family": "Teixeira", "given": "Ana", "initials": "A"}, {"family": "Lopes", "given": "Maria Francelina", "initials": "MF"}, {"family": "Kalici\u0144ski", "given": "Piotr", "initials": "P"}, {"family": "Branchereau", "given": "Sophie", "initials": "S"}, {"family": "Boyer", "given": "Olivia", "initials": "O"}, {"family": "Debray", "given": "Dominque", "initials": "D"}, {"family": "Sciveres", "given": "Marco", "initials": "M"}, {"family": "Wennberg", "given": "Lars", "initials": "L"}, {"family": "Fischler", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Barany", "given": "Peter", "initials": "P"}, {"family": "Baker", "given": "Alastair", "initials": "A"}, {"family": "Baumann", "given": "Ulrich", "initials": "U"}, {"family": "Schwerk", "given": "Nicolaus", "initials": "N"}, {"family": "Nicastro", "given": "Emanuele", "initials": "E"}, {"family": "Candusso", "given": "Manila", "initials": "M"}, {"family": "Toporski", "given": "Jacek", "initials": "J"}, {"family": "Sokal", "given": "Etienne", "initials": "E"}, {"family": "Stephenne", "given": "Xavier", "initials": "X"}, {"family": "Lindemans", "given": "Caroline", "initials": "C"}, {"family": "Miglinas", "given": "Marius", "initials": "M"}, {"family": "Rascon", "given": "Jelena", "initials": "J"}, {"family": "Jara", "given": "Paloma", "initials": "P"}, {"family": "ERN TransplantChild", "given": "", "initials": ""}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Clin Transplant", "issn": "1399-0012", "volume": "34", "issue": "10", "pages": "e14063", "issn-l": null}, "abstract": "The current pandemic SARS-CoV-2 has required an unusual allocation of resources that can negatively impact chronically ill patients and high-complexity procedures. Across the European Reference Network on Pediatric Transplantation (ERN TransplantChild), we conducted a survey to investigate the impact of the COVID-19 outbreak on pediatric transplant activity and healthcare practices in both solid organ transplantation (SOT) and hematopoietic stem cell transplantation (HSCT). The replies of 30 professionals from 18 centers in Europe were collected. Twelve of 18 centers (67%) showed a reduction in their usual transplant activity. Additionally, outpatient visits have been modified and restricted to selected ones, and the use of telemedicine tools has increased. Additionally, a total of 14 COVID-19 pediatric transplanted patients were identified at the time of the survey, including eight transplant recipients and six candidates for transplantation. Only two moderate-severe cases were reported, both in HSCT setting. These survey results demonstrate the limitations in healthcare resources for pediatric transplantation patients during early stages of this pandemic. COVID-19 disease is a major worldwide challenge for the field of pediatric transplantation, where there will be a need for systematic data collection, encouraging regular discussions to address the long-term consequences for pediatric transplantation candidates, recipients, and their families.", "doi": "10.1111/ctr.14063", "pmid": "32786120", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7435500"}], "notes": [], "created": "2020-12-07T13:28:32.289Z", "modified": "2020-12-07T13:28:32.314Z"}, {"entity": "publication", "iuid": "04e4c4b436a346d5aab70592cfa88caf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/04e4c4b436a346d5aab70592cfa88caf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/04e4c4b436a346d5aab70592cfa88caf"}}, "title": "Pathophysiology of the COVID-19 - entry to the CNS through the nose.", "authors": [{"family": "Ylikoski", "given": "Jukka", "initials": "J"}, {"family": "Markkanen", "given": "Marika", "initials": "M"}, {"family": "M\u00e4kitie", "given": "Antti", "initials": "A"}], "type": "editorial", "published": "2020-10-00", "journal": {"title": "Acta Otolaryngol", "issn": "1651-2251", "volume": "140", "issue": "10", "pages": "886-889", "issn-l": "0001-6489"}, "abstract": null, "doi": "10.1080/00016489.2020.1773533", "pmid": "32597276", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-26T12:25:16.279Z", "modified": "2020-11-30T08:54:52.911Z"}, {"entity": "publication", "iuid": "96b0715e8c8b4184a63d7666de8d709d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/96b0715e8c8b4184a63d7666de8d709d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/96b0715e8c8b4184a63d7666de8d709d"}}, "title": "Paediatric COVID-19 admissions in a region with open schools during the two first months of the pandemic.", "authors": [{"family": "Hildenwall", "given": "Helena", "initials": "H"}, {"family": "Luthander", "given": "Joachim", "initials": "J"}, {"family": "Rhedin", "given": "Samuel", "initials": "S"}, {"family": "Hertting", "given": "Olof", "initials": "O"}, {"family": "Olsson-\u00c5kefeldt", "given": "Selma", "initials": "S"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Alfv\u00e9n", "given": "Tobias", "initials": "T"}, {"family": "Herlenius", "given": "Eric", "initials": "E"}, {"family": "Ryd Rinder", "given": "Malin", "initials": "M"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": "109", "issue": "10", "pages": "2152-2154", "issn-l": "0803-5253"}, "abstract": null, "doi": "10.1111/apa.15432", "pmid": "32567145", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7323214"}], "notes": [], "created": "2020-12-08T16:30:28.877Z", "modified": "2021-02-26T08:45:48.478Z"}, {"entity": "publication", "iuid": "8a9af387c8834711aab4872a8c36a9e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a9af387c8834711aab4872a8c36a9e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a9af387c8834711aab4872a8c36a9e7"}}, "title": "Open synthesis and the coronavirus pandemic in 2020.", "authors": [{"family": "Haddaway", "given": "Neal R", "initials": "NR"}, {"family": "Akl", "given": "Elie A", "initials": "EA"}, {"family": "Page", "given": "Matthew J", "initials": "MJ"}, {"family": "Welch", "given": "Vivian A", "initials": "VA"}, {"family": "Keenan", "given": "Ciara", "initials": "C"}, {"family": "Lotfi", "given": "Tamara", "initials": "T"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "J Clin Epidemiol", "issn": "1878-5921", "volume": "126", "issue": null, "pages": "184-191", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jclinepi.2020.06.032", "pmid": "32621854", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0895-4356(20)30461-3"}, {"db": "pmc", "key": "PMC7328560"}], "notes": [], "created": "2020-11-30T08:51:27.807Z", "modified": "2020-11-30T08:51:27.832Z"}, {"entity": "publication", "iuid": "c416ec4ee19a4167910ae1f8f02cc9a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c416ec4ee19a4167910ae1f8f02cc9a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c416ec4ee19a4167910ae1f8f02cc9a6"}}, "title": "No small matter: a perspective on nanotechnology-enabled solutions to fight COVID-19.", "authors": [{"family": "Jones", "given": "Georgia Wilson", "initials": "GW"}, {"family": "Monopoli", "given": "Marco P", "initials": "MP"}, {"family": "Campagnolo", "given": "Luisa", "initials": "L"}, {"family": "Pietroiusti", "given": "Antonio", "initials": "A"}, {"family": "Tran", "given": "Lang", "initials": "L"}, {"family": "Fadeel", "given": "Bengt", "initials": "B"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Nanomedicine (Lond)", "issn": "1748-6963", "volume": "15", "issue": "24", "pages": "2411-2427", "issn-l": null}, "abstract": "There is an urgent need for safe and effective approaches to combat COVID-19. Here, we asked whether lessons learned from nanotoxicology and nanomedicine could shed light on the current pandemic. SARS-CoV-2, the causative agent, may trigger a mild, self-limiting disease with respiratory symptoms, but patients may also succumb to a life-threatening systemic disease. The host response to the virus is equally complex and studies are now beginning to unravel the immunological correlates of COVID-19. Nanotechnology can be applied for the delivery of antiviral drugs or other repurposed drugs. Moreover, recent work has shown that synthetic nanoparticles wrapped with host-derived cellular membranes may prevent virus infection. We posit that nanoparticles decorated with ACE2, the receptor for SARS-CoV-2, could be exploited as decoys to intercept the virus before it infects cells in the respiratory tract. However, close attention should be paid to biocompatibility before such nano-decoys are deployed in the clinic.", "doi": "10.2217/nnm-2020-0286", "pmid": "32873192", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7488724"}], "notes": [], "created": "2020-12-06T07:36:25.377Z", "modified": "2020-12-06T07:36:25.402Z"}, {"entity": "publication", "iuid": "59b00923374e47adbc0f1d94c7e13e40", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/59b00923374e47adbc0f1d94c7e13e40.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/59b00923374e47adbc0f1d94c7e13e40"}}, "title": "Neurological manifestations of coronavirus infections - a systematic review.", "authors": [{"family": "Almqvist", "given": "Jesper", "initials": "J"}, {"family": "Granberg", "given": "Tobias", "initials": "T"}, {"family": "Tzortzakakis", "given": "Antonios", "initials": "A"}, {"family": "Klironomos", "given": "Stefanos", "initials": "S"}, {"family": "Kollia", "given": "Evangelia", "initials": "E"}, {"family": "\u00d6hberg", "given": "Claes", "initials": "C"}, {"family": "Martin", "given": "Roland", "initials": "R"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Ouellette", "given": "Russell", "initials": "R"}, {"family": "Ineichen", "given": "Benjamin V", "initials": "BV"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Ann Clin Transl Neurol", "issn": "2328-9503", "volume": "7", "issue": "10", "pages": "2057-2071", "issn-l": "2328-9503"}, "abstract": "To optimize diagnostic workup of the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, we systematically reviewed neurological and neuroradiological manifestations of SARS-CoV-2 and all other known human coronavirus species (HCoV). Which lessons can we learn? We identified relevant publications (until 26 July 2020) using systematic searches in PubMed, Web of Science, and Ovid EMBASE with predefined search strings. A total of 4571 unique publications were retrieved, out of which 378 publications were selected for in-depth analysis by two raters, including a total of 17549 (out of which were 14418 SARS-CoV-2) patients. Neurological complications and associated neuroradiological manifestations are prevalent for all HCoVs (HCoV-229E, HKU1, NL63, OC43, Middle East respiratory syndrome (MERS)-CoV, SARS-CoV-1, and SARS-CoV-2). Moreover there are similarities in symptomatology across different HCoVs, particularly between SARS-CoV-1 and SARS-CoV-2. Common neurological manifestations include fatigue, headache, and smell/taste disorders. Additionally, clinicians need to be attentive for at least five classes of neurological complications: (1) Cerebrovascular disorders including ischemic stroke and macro/micro-hemorrhages, (2) encephalopathies, (3) para-/postinfectious immune-mediated complications such as Guillain-Barr\u00e9 syndrome and acute disseminated encephalomyelitis, (4) (meningo-)encephalitis, potentially with concomitant seizures, and (5) neuropsychiatric complications such as psychosis and mood disorders. Our systematic review highlights the need for vigilance regarding neurological complications in patients infected by SARS-CoV-2 and other HCoVs, especially since some complications may result in chronic disability. Neuroimaging protocols should be designed to specifically screen for these complications. Therefore, we propose practical imaging guidelines to facilitate the diagnostic workup and monitoring of patients infected with HCoVs.", "doi": "10.1002/acn3.51166", "pmid": "32853453", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7461163"}], "notes": [], "created": "2020-11-26T12:17:30.281Z", "modified": "2020-11-30T08:36:35.331Z"}, {"entity": "publication", "iuid": "442c80b494834398a3e3d3882c5ea990", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/442c80b494834398a3e3d3882c5ea990.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/442c80b494834398a3e3d3882c5ea990"}}, "title": "Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia (COVID STEROID) trial-Protocol and statistical analysis plan.", "authors": [{"family": "Petersen", "given": "Marie Warrer", "initials": "MW"}, {"family": "Meyhoff", "given": "Tine Sylvest", "initials": "TS"}, {"family": "Helleberg", "given": "Marie", "initials": "M"}, {"family": "Kjaer", "given": "Maj-Brit N\u00f8rregaard", "initials": "MN"}, {"family": "Granholm", "given": "Anders", "initials": "A"}, {"family": "Hjorts\u00f8", "given": "Carl Johan Steensen", "initials": "CJS"}, {"family": "Jensen", "given": "Thomas Steen", "initials": "TS"}, {"family": "M\u00f8ller", "given": "Morten Hylander", "initials": "MH"}, {"family": "Hjortrup", "given": "Peter Buhl", "initials": "PB"}, {"family": "Wetterslev", "given": "Mik", "initials": "M"}, {"family": "Vesterlund", "given": "Gitte Kingo", "initials": "GK"}, {"family": "Russell", "given": "Lene", "initials": "L"}, {"family": "J\u00f8rgensen", "given": "Vibeke Lind", "initials": "VL"}, {"family": "Tjelle", "given": "Klaus", "initials": "K"}, {"family": "Benfield", "given": "Thomas", "initials": "T"}, {"family": "Ulrik", "given": "Charlotte Suppli", "initials": "CS"}, {"family": "Andreasen", "given": "Anne Sofie", "initials": "AS"}, {"family": "Mohr", "given": "Thomas", "initials": "T"}, {"family": "Bestle", "given": "Morten H", "initials": "MH"}, {"family": "Poulsen", "given": "Lone Musaeus", "initials": "LM"}, {"family": "Hitz", "given": "Mette Friberg", "initials": "MF"}, {"family": "Hildebrandt", "given": "Thomas", "initials": "T"}, {"family": "Knudsen", "given": "Lene Surland", "initials": "LS"}, {"family": "M\u00f8ller", "given": "Anders", "initials": "A"}, {"family": "S\u00f8lling", "given": "Christoffer Grant", "initials": "CG"}, {"family": "Br\u00f8chner", "given": "Anne Craveiro", "initials": "AC"}, {"family": "Rasmussen", "given": "Bodil Steen", "initials": "BS"}, {"family": "Nielsen", "given": "Henrik", "initials": "H"}, {"family": "Christensen", "given": "Steffen", "initials": "S"}, {"family": "Str\u00f8m", "given": "Thomas", "initials": "T"}, {"family": "Cronhjort", "given": "Maria", "initials": "M"}, {"family": "Wahlin", "given": "Rebecka Rubenson", "initials": "RR"}, {"family": "Jakob", "given": "Stephan", "initials": "S"}, {"family": "Cioccari", "given": "Luca", "initials": "L"}, {"family": "Venkatesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Hammond", "given": "Naomi", "initials": "N"}, {"family": "Jha", "given": "Vivekanand", "initials": "V"}, {"family": "Myatra", "given": "Sheila Nainan", "initials": "SN"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Lange", "given": "Theis", "initials": "T"}, {"family": "Perner", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "volume": "64", "issue": "9", "pages": "1365-1375", "issn-l": "0001-5172"}, "abstract": "Severe acute respiratory syndrome coronavirus-2 has caused a pandemic of coronavirus disease (COVID-19) with many patients developing hypoxic respiratory failure. Corticosteroids reduce the time on mechanical ventilation, length of stay in the intensive care unit and potentially also mortality in similar patient populations. However, corticosteroids have undesirable effects, including longer time to viral clearance. Clinical equipoise on the use of corticosteroids for COVID-19 exists.\n\nThe COVID STEROID trial is an international, randomised, stratified, blinded clinical trial. We will allocate 1000 adult patients with COVID-19 receiving \u226510 L/min of oxygen or on mechanical ventilation to intravenous hydrocortisone 200 mg daily vs placebo (0.9% saline) for 7 days. The primary outcome is days alive without life support (ie mechanical ventilation, circulatory support, and renal replacement therapy) at day 28. Secondary outcomes are serious adverse reactions at day 14; days alive without life support at day 90; days alive and out of hospital at day 90; all-cause mortality at day 28, day 90, and 1 year; and health-related quality of life at 1 year. We will conduct the statistical analyses according to this protocol, including interim analyses for every 250 patients followed for 28 days. The primary outcome will be compared using the Kryger Jensen and Lange test in the intention to treat population and reported as differences in means and medians with 95% confidence intervals.\n\nThe COVID STEROID trial will provide important evidence to guide the use of corticosteroids in COVID-19 and severe hypoxia.", "doi": "10.1111/aas.13673", "pmid": "32779728", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7404666"}], "notes": [], "created": "2020-12-07T13:32:20.495Z", "modified": "2021-02-26T08:45:48.099Z"}, {"entity": "publication", "iuid": "b1323021dc7d45f6b4afca061534617c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1323021dc7d45f6b4afca061534617c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1323021dc7d45f6b4afca061534617c"}}, "title": "Long-term consequences of COVID-19: research needs.", "authors": [{"family": "Yelin", "given": "Dana", "initials": "D"}, {"family": "Wirtheim", "given": "Eytan", "initials": "E"}, {"family": "Vetter", "given": "Pauline", "initials": "P"}, {"family": "Kalil", "given": "Andre C", "initials": "AC"}, {"family": "Bruchfeld", "given": "Judith", "initials": "J"}, {"family": "Runold", "given": "Michael", "initials": "M"}, {"family": "Guaraldi", "given": "Giovanni", "initials": "G"}, {"family": "Mussini", "given": "Cristina", "initials": "C"}, {"family": "Gudiol", "given": "Carlota", "initials": "C"}, {"family": "Pujol", "given": "Miquel", "initials": "M"}, {"family": "Bandera", "given": "Alessandra", "initials": "A"}, {"family": "Scudeller", "given": "Luigia", "initials": "L"}, {"family": "Paul", "given": "Mical", "initials": "M"}, {"family": "Kaiser", "given": "Laurent", "initials": "L"}, {"family": "Leibovici", "given": "Leonard", "initials": "L"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "volume": "20", "issue": "10", "pages": "1115-1117", "issn-l": null}, "abstract": null, "doi": "10.1016/S1473-3099(20)30701-5", "pmid": "32888409", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(20)30701-5"}, {"db": "pmc", "key": "PMC7462626"}], "notes": [], "created": "2020-12-06T07:25:57.455Z", "modified": "2020-12-06T07:26:37.438Z"}, {"entity": "publication", "iuid": "15e7e3fed3654797aae82e30150d72d6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15e7e3fed3654797aae82e30150d72d6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15e7e3fed3654797aae82e30150d72d6"}}, "title": "Laser irradiated phenothiazines: New potential treatment for COVID-19 explored by molecular docking.", "authors": [{"family": "Udrea", "given": "Ana-Maria", "initials": "AM"}, {"family": "Avram", "given": "Speranta", "initials": "S"}, {"family": "Nistorescu", "given": "Simona", "initials": "S"}, {"family": "Pascu", "given": "Mihail-Lucian", "initials": "ML"}, {"family": "Romanitan", "given": "Mihaela Oana", "initials": "MO"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "J Photochem Photobiol B", "issn": "1873-2682", "volume": "211", "issue": null, "pages": "111997", "issn-l": null}, "abstract": "The worldwide infection with the new Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) demands urgently new potent treatment(s). In this study we predict, using molecular docking, the binding affinity of 15 phenothiazines (antihistaminic and antipsychotic drugs) when interacting with the main protease (M pro) of SARS-CoV-2. Additionally, we tested the binding affinity of photoproducts identified after irradiation of phenothiazines with Nd:YAG laser beam at 266 nm respectively 355 nm. Our results reveal that thioridazine and its identified photoproducts (mesoridazine and sulforidazine) have high biological activity on the virus Mpro. This shows that thioridazine and its two photoproducts might represent new potent medicines to be used for treatment in this outbreak. Such results recommend these medicines for further tests on cell cultures infected with SARS-CoV-2 or animal model. The transition to human subjects of the suggested treatment will be smooth due to the fact that the drugs are already available on the market.", "doi": "10.1016/j.jphotobiol.2020.111997", "pmid": "32829256", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S1011-1344(20)30447-4"}, {"db": "pmc", "key": "PMC7428740"}], "notes": [], "created": "2020-12-07T11:46:08.690Z", "modified": "2021-02-26T08:45:02.860Z"}, {"entity": "publication", "iuid": "b630793a5e87457eaa2ed82dc2b65c38", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b630793a5e87457eaa2ed82dc2b65c38.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b630793a5e87457eaa2ed82dc2b65c38"}}, "title": "Is COVID-19 associated thrombosis caused by overactivation of the complement cascade? A literature review.", "authors": [{"family": "Fletcher-Sandersj\u00f6\u00f6", "given": "Alexander", "initials": "A"}, {"family": "Bellander", "given": "Bo-Michael", "initials": "BM"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Thromb Res", "issn": "1879-2472", "volume": "194", "issue": null, "pages": "36-41", "issn-l": "0049-3848"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 is responsible for the current COVID-19 pandemic resulting in an escalating number of cases and fatalities worldwide. Preliminary evidence from these patients, as well as past coronavirus epidemics, indicates that those infected suffer from disproportionate complement activation as well as excessive coagulation, leading to thrombotic complications and poor outcome. In non-coronavirus cohorts, evidence has accumulated of an interaction between the complement and coagulation systems, with one amplifying activation of the other. A pressing question is therefore if COVID-19 associated thrombosis could be caused by overactivation of the complement cascade? In this review, we summarize the literature on thrombotic complications in COVID-19, complement activation in coronavirus infections, and the crosstalk between the complement and coagulation systems. We demonstrate how the complement system is able to activate the coagulation cascade and platelets, inhibit fibrinolysis and stimulate endothelial cells. We also describe how these interactions see clinical relevance in several disorders where overactive complement results in a prothrombotic clinical presentation, and how it could be clinically relevant in COVID-19.", "doi": "10.1016/j.thromres.2020.06.027", "pmid": "32569879", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0049-3848(20)30269-3"}, {"db": "pmc", "key": "PMC7301826"}], "notes": [], "created": "2020-11-26T12:14:19.289Z", "modified": "2020-11-30T08:59:18.013Z"}, {"entity": "publication", "iuid": "6ac2ef0d1f96420ba6da209a41beff4b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ac2ef0d1f96420ba6da209a41beff4b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ac2ef0d1f96420ba6da209a41beff4b"}}, "title": "Invasive mechanical ventilation in a former preterm infant with COVID-19.", "authors": [{"family": "Nyholm", "given": "Silvia", "initials": "S"}, {"family": "Edner", "given": "Ann", "initials": "A"}, {"family": "Myrelid", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Janols", "given": "Helena", "initials": "H"}, {"family": "D\u00f6renberg", "given": "Rainer", "initials": "R"}, {"family": "Diderholm", "given": "Barbro", "initials": "B"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": "109", "issue": "10", "pages": "2141-2143", "issn-l": "0803-5253"}, "abstract": null, "doi": "10.1111/apa.15437", "pmid": "32569422", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7361564"}], "notes": [], "created": "2020-12-08T16:28:27.718Z", "modified": "2020-12-08T16:28:27.730Z"}, {"entity": "publication", "iuid": "6ebda7bd436a47428776a6a0d65f6831", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ebda7bd436a47428776a6a0d65f6831.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ebda7bd436a47428776a6a0d65f6831"}}, "title": "Interventions to Reduce Aerosolized Microbes in Dental Practice: A Systematic Review with Network Meta-analysis of Randomized Controlled Trials.", "authors": [{"family": "Koletsi", "given": "D", "initials": "D"}, {"family": "Belibasakis", "given": "G N", "initials": "GN"}, {"family": "Eliades", "given": "T", "initials": "T"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "J Dent Res", "issn": "1544-0591", "volume": "99", "issue": "11", "pages": "1228-1238", "issn-l": "0022-0345"}, "abstract": "The aim of this systematic review and network meta-analysis was to identify and rank the effectiveness of different interventions used in dental practice to reduce microbial load in aerosolized compounds. Seven electronic databases were searched to April 6, 2020, for randomized controlled trials (RCTs) or nonrandomized prospective studies in the field. Study selection, data extraction, and risk-of-bias assessment were performed for all included studies, while the outcome of interest pertained to differences in bacterial load quantification through the use of different interventions prior to aerosol-generating procedures in dental practices. Random effects frequentist network meta-analysis was performed, with mean difference (MD) and 95% CI as the effect measure. Confidence in the documented evidence was assessed through the newly fueled CINeMA framework (Confidence in Network Meta-analysis) based on the GRADE approach (Grading of Recommendations, Assessment, Development and Evaluation). Twenty-nine clinical trials were deemed eligible, 21 RCTs and 8 nonrandomized studies, while 11 RCTs contributed to the network meta-analysis, comprising 10 competing interventions. Tempered chlorhexidine (CHX) 0.2% as compared with nonactive control mouth rinse, prior to routine ultrasonic scaling, was most effective toward reduced postprocedural bacterial load with an MD of -0.92 (95% CI, -1.54 to -0.29) in log 10 bacterial CFUs (colony-forming units). For CHX 0.2%, an MD of -0.74 (95% CI, -1.07 to -0.40) was observed as compared with control. Tempered CHX 0.2% presented the highest probabilities of being ranked the most effective treatment (31.2%). Level of confidence varied from very low to moderate across all formulated comparisons. These findings summarize the current state of research evidence in the field of aerosolized bacteria in dentistry. Instigated by the era of SARS-CoV-2 pandemic, the stipulation of a broader evaluation of the aerosolized microbes, including viruses, potentially coupled with disinfectant-based prevention schemes should be prioritized.", "doi": "10.1177/0022034520943574", "pmid": "32660314", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-26T12:20:02.782Z", "modified": "2020-11-30T08:51:23.085Z"}, {"entity": "publication", "iuid": "8043a8d98fa242cfa5e92cf1d93b58b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8043a8d98fa242cfa5e92cf1d93b58b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8043a8d98fa242cfa5e92cf1d93b58b2"}}, "title": "Increasing maternal mortality associated with COVID-19 and shortage of intensive care is a serious concern in low-resource settings.", "authors": [{"family": "Silveira Campos", "given": "Luciana", "initials": "L"}, {"family": "Peixoto Caldas", "given": "Jos\u00e9 M", "initials": "JM"}], "type": "letter", "published": "2020-10-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "10", "pages": "1421", "issn-l": "0001-6349"}, "abstract": null, "doi": "10.1111/aogs.13975", "pmid": "32799338", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7461434"}], "notes": [], "created": "2020-12-07T13:22:08.337Z", "modified": "2020-12-07T13:22:08.347Z"}, {"entity": "publication", "iuid": "3c78deda48504db9a8f995bd38917104", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3c78deda48504db9a8f995bd38917104.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3c78deda48504db9a8f995bd38917104"}}, "title": "In silico Potential of Approved Antimalarial Drugs for Repurposing Against COVID-19.", "authors": [{"family": "Sachdeva", "given": "Cheryl", "initials": "C"}, {"family": "Wadhwa", "given": "Anju", "initials": "A"}, {"family": "Kumari", "given": "Anita", "initials": "A"}, {"family": "Hussain", "given": "Firasat", "initials": "F"}, {"family": "Jha", "given": "Preeti", "initials": "P"}, {"family": "Kaushik", "given": "Naveen K", "initials": "NK"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "OMICS", "issn": "1557-8100", "volume": "24", "issue": "10", "pages": "568-580", "issn-l": "1536-2310"}, "abstract": "Although the coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is wreaking havoc and resulting in mortality and morbidity across the planet, novel treatments are urgently needed. Drug repurposing offers an innovative approach in this context. We report here new findings on the in silico potential of several antimalarial drugs for repurposing against COVID-19. We conducted analyses by docking the compounds against two SARS-CoV-2-specific targets: (1) the receptor binding domain spike protein and (2) the main protease of the virus (MPro) using the Schr\u00f6dinger software. Importantly, the docking analysis revealed that doxycycline (DOX) showed the most effective binding to the spike protein of SARS-CoV-2, whereas halofantrine and mefloquine bound effectively with the main protease among the antimalarial drugs evaluated in the present study. The in silico approach reported here suggested that DOX could potentially be a good candidate for repurposing for COVID-19. In contrast, to decipher the actual potential of DOX and halofantrine against COVID-19, further in vitro and in vivo studies are called for. Drug repurposing warrants consideration as a viable research and innovation avenue as planetary health efforts to fight the COVID-19 continue.", "doi": "10.1089/omi.2020.0071", "pmid": "32757981", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2020-11-19T14:41:00.439Z", "modified": "2021-02-26T08:45:02.956Z"}, {"entity": "publication", "iuid": "ee6cb4249076448a8c69ea2732de3566", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee6cb4249076448a8c69ea2732de3566.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee6cb4249076448a8c69ea2732de3566"}}, "title": "High excess mortality in areas with young and socially vulnerable populations during the COVID-19 outbreak in Stockholm Region, Sweden.", "authors": [{"family": "Calder\u00f3n-Larra\u00f1aga", "given": "Amaia", "initials": "A", "orcid": "0000-0001-9064-9222", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/166407b0da5346b3aef841949b0212da.json"}}, {"family": "Vetrano", "given": "Davide L", "initials": "DL"}, {"family": "Rizzuto", "given": "Debora", "initials": "D"}, {"family": "Bellander", "given": "Tom", "initials": "T"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Dekhtyar", "given": "Serhiy", "initials": "S"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "issn-l": "2059-7908", "volume": "5", "issue": "10", "pages": "e003595"}, "abstract": "We aimed to describe the distribution of excess mortality (EM) during the first weeks of the COVID-19 outbreak in the Stockholm Region, Sweden, according to age, sex and sociodemographic context.\n\nWeekly all-cause mortality data were obtained from Statistics Sweden for the period 1 January 2015 to 17 May 2020. EM during the first 20 weeks of 2020 was estimated by comparing observed mortality rates with expected mortality rates during the five previous years (N=2 379 792). EM variation by socioeconomic status (tertiles of income, education, Swedish-born, gainful employment) and age distribution (share of 70+-year-old persons) was explored based on Demographic Statistics Area (DeSO) data.\n\nEM was first detected during the week of 23-29 March 2020. During the peak week of the epidemic (6-12 April 2020), an EM of 150% was observed (152% in 80+-year-old women; 183% in 80+-year-old men). During the same week, the highest EM was observed for DeSOs with lowest income (171%), lowest education (162%), lowest share of Swedish-born (178%) and lowest share of gainfully employed residents (174%). EM was further increased in areas with higher versus lower proportion of younger people (magnitude of increase: 1.2-1.7 times depending on socioeconomic measure).\n\nLiving in areas characterised by lower socioeconomic status and younger populations was linked to excess mortality during the COVID-19 pandemic in the Stockholm Region. These conditions might have facilitated viral spread. Our findings highlight the well-documented vulnerability linked to increasing age and sociodemographic context for COVID-19-related death.", "doi": "10.1136/bmjgh-2020-003595", "pmid": "33109636", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7592025"}, {"db": "pii", "key": "bmjgh-2020-003595"}], "notes": [], "created": "2020-11-27T10:24:44.096Z", "modified": "2023-06-19T15:28:44.800Z"}, {"entity": "publication", "iuid": "e4d57f90525b4263818c08975dabc530", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e4d57f90525b4263818c08975dabc530.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e4d57f90525b4263818c08975dabc530"}}, "title": "Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes.", "authors": [{"family": "Robinson", "given": "Emma L", "initials": "EL"}, {"family": "Alkass", "given": "Kanar", "initials": "K"}, {"family": "Bergmann", "given": "Olaf", "initials": "O"}, {"family": "Maguire", "given": "Janet J", "initials": "JJ"}, {"family": "Roderick", "given": "H Llewelyn", "initials": "HL"}, {"family": "Davenport", "given": "Anthony P", "initials": "AP"}], "type": "letter", "published": "2020-10-00", "journal": {"title": "J Mol Cell Cardiol", "issn": "1095-8584", "volume": "147", "issue": null, "pages": "88-91", "issn-l": null}, "abstract": null, "doi": "10.1016/j.yjmcc.2020.08.009", "pmid": "32818486", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0022-2828(20)30257-1"}, {"db": "pmc", "key": "PMC7431326"}], "notes": [], "created": "2020-12-07T12:24:07.369Z", "modified": "2021-02-26T08:45:48.812Z"}, {"entity": "publication", "iuid": "1d34fda32e3344aca9277e9b656cbcb2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d34fda32e3344aca9277e9b656cbcb2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d34fda32e3344aca9277e9b656cbcb2"}}, "title": "Future liasing of the lockdown during COVID-19 pandemic: The dawn is expected at hand from the darkest hour.", "authors": [{"family": "Khursheed", "given": "Anwar", "initials": "A"}, {"family": "Alam", "given": "Shamshad", "initials": "S"}, {"family": "Tyagi", "given": "Vinay Kumar", "initials": "VK"}, {"family": "Nagpure", "given": "Ajay S", "initials": "AS"}, {"family": "Khan", "given": "Abid Ali", "initials": "AA"}, {"family": "Gaur", "given": "Rubia Z", "initials": "RZ"}, {"family": "Singh", "given": "Sanyogita", "initials": "S"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Mukherjee", "given": "Santanu", "initials": "S"}, {"family": "Kumar", "given": "Manish", "initials": "M"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Groundw Sustain Dev", "issn": "2352-801X", "volume": "11", "issue": null, "pages": "100433", "issn-l": null}, "abstract": "The lockdown during COVID-19 pandemic has converted the world into new experimental laboratories, which may reveal temporal or spatial comparative analysis data. However, some startling information is gathered in terms of reduced premature mortality cases associated with air and water quality improvement, enhanced e-learning on a broader platform, work from home, and successful e-health. The decline in vehicular density on roads and congestion leads to reduced energy consumption and associated greenhouse gases (GHG) and other pollutants emission. The lockdown has also been identified as a possible emergency measure to combat severe air pollution episodes. Similarly, industrial pollution has been recognized as one of the primary causes of water resource pollution and would, therefore, bring change in policy vis-\u00e0-vis groundwater pollution control. Our findings suggest that the results of successful e-learning and work from home would be a permanent shift from conventional modes in the near future due to a drastic reduction in socio-economic cost. Our critical analysis also highlights that with such temporary lockdown measures acute/chronic ill-effects of anthropogenic perturbations on planet earth can be effectively estimated through sociocultural, socioeconomical and socio-political/sociotechnological nexus.", "doi": "10.1016/j.gsd.2020.100433", "pmid": "32835071", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2352-801X(20)30268-X"}, {"db": "pii", "key": "100433"}, {"db": "pmc", "key": "PMC7319642"}], "notes": [], "created": "2020-12-07T11:44:03.369Z", "modified": "2020-12-07T11:44:03.393Z"}, {"entity": "publication", "iuid": "ce1eb385f7aa43f881128314a8d2ae21", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ce1eb385f7aa43f881128314a8d2ae21.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ce1eb385f7aa43f881128314a8d2ae21"}}, "title": "Forgotten Technology in the COVID-19 Pandemic: Filtration Properties of Cloth and Cloth Masks-A Narrative Review.", "authors": [{"family": "Clase", "given": "Catherine M", "initials": "CM"}, {"family": "Fu", "given": "Edouard L", "initials": "EL"}, {"family": "Ashur", "given": "Aurneen", "initials": "A"}, {"family": "Beale", "given": "Rupert C L", "initials": "RCL"}, {"family": "Clase", "given": "Imogen A", "initials": "IA"}, {"family": "Dolovich", "given": "Myrna B", "initials": "MB"}, {"family": "Jardine", "given": "Meg J", "initials": "MJ"}, {"family": "Joseph", "given": "Meera", "initials": "M"}, {"family": "Kansiime", "given": "Grace", "initials": "G"}, {"family": "Mann", "given": "Johannes F E", "initials": "JFE"}, {"family": "Pecoits-Filho", "given": "Roberto", "initials": "R"}, {"family": "Winkelmayer", "given": "Wolfgang C", "initials": "WC"}, {"family": "Carrero", "given": "Juan J", "initials": "JJ"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Mayo Clin Proc", "issn": "1942-5546", "volume": "95", "issue": "10", "pages": "2204-2224", "issn-l": "0025-6196"}, "abstract": "Management of the global crisis of the coronavirus disease 2019 pandemic requires detailed appraisal of evidence to support clear, actionable, and consistent public health messaging. The use of cloth masks for general public use is being debated, and is in flux. We searched the MEDLINE and EMBASE databases and Google for articles reporting the filtration properties of flat cloth or cloth masks. We reviewed the reference lists of relevant articles to identify further articles and identified articles through social and conventional news media. We found 25 articles. Study of protection for the wearer used healthy volunteers, or used a manikin wearing a mask, with airflow to simulate different breathing rates. Studies of protection of the environment, also known as source control, used convenience samples of healthy volunteers. The design and execution of the studies was generally rigorously described. Many descriptions of cloth lacked the detail required for reproducibility; no study provided all the expected details of material, thread count, weave, and weight. Some of the homemade mask designs were reproducible. Successful masks were made of muslin at 100 threads per inch (TPI) in 3 to 4 layers (4-layer muslin or a muslin-flannel-muslin sandwich), tea towels (also known as dish towels), made using 1 layer (2 layers would be expected to be better), and good-quality cotton T-shirts in 2 layers (with a stitched edge to prevent stretching). In flat-cloth experiments, linen tea towels, 600-TPI cotton in 2 layers, and 600-TPI cotton with 90-TPI flannel performed well but 80-TPI cotton in 2 layers did not. We therefore recommend cotton or flannel at least 100 TPI, at least 2 layers. More layers, 3 or 4, will provide increased filtration but there is a trade-off in that more layers increases the resistance to breathing. Although this is not a systematic review, we included all the articles that we identified in an unbiased way. We did not include gray literature or preprints. A plain language summary of these data and recommendations, as well as information on making, wearing and cleaning cloth masks is available at www.clothmasks.ca.", "doi": "10.1016/j.mayocp.2020.07.020", "pmid": "33012350", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0025-6196(20)30826-0"}], "notes": [], "created": "2020-11-26T12:30:06.960Z", "modified": "2020-11-26T12:30:06.978Z"}, {"entity": "publication", "iuid": "4e6914020d7d475d935aa1ca7e8a49e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4e6914020d7d475d935aa1ca7e8a49e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4e6914020d7d475d935aa1ca7e8a49e7"}}, "title": "Existing highly accumulating lysosomotropic drugs with potential for repurposing to target COVID-19.", "authors": [{"family": "Norinder", "given": "Ulf", "initials": "U"}, {"family": "Tuck", "given": "Astrud", "initials": "A"}, {"family": "Norgren", "given": "Kalle", "initials": "K"}, {"family": "Munic Kos", "given": "Vesna", "initials": "V"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Biomed Pharmacother", "issn": "1950-6007", "volume": "130", "issue": null, "pages": "110582", "issn-l": "0753-3322"}, "abstract": "Given the speed of viral infection spread, repurposing of existing drugs has been given the highest priority in combating the ongoing COVID-19 pandemic. Only drugs that are already registered or close to registration, and therefore have passed lengthy safety assessments, have a chance to be tested in clinical trials and reach patients quickly enough to help in the current disease outbreak. Here, we have reviewed available evidence and possible ways forward to identify already existing pharmaceuticals displaying modest broad-spectrum antiviral activity which is likely linked to their high accumulation in cells. Several well studied examples indicate that these drugs accumulate in lysosomes, endosomes and biological membranes in general, and thereby interfere with endosomal pathway and intracellular membrane trafficking crucial for viral infection. With the aim to identify other lysosomotropic drugs with possible inherent antiviral activity, we have applied a set of clear physicochemical, pharmacokinetic and molecular criteria on 530 existing drugs. In addition to publicly available data, we have also used our in silico model for the prediction of accumulation in lysosomes and endosomes. By this approach we have identified 36 compounds with possible antiviral effects, also against coronaviruses. For 14 of them evidence of broad-spectrum antiviral activity has already been reported, adding support to the value of this approach. Presented pros and cons, knowledge gaps and methods to identify lysosomotropic antivirals, can help in the evaluation of many drugs currently in clinical trials considered for repurposing to target COVID-19, as well as open doors to finding more potent and safer alternatives.", "doi": "10.1016/j.biopha.2020.110582", "pmid": "32763818", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0753-3322(20)30775-7"}, {"db": "pmc", "key": "PMC7392152"}], "notes": [], "created": "2020-11-26T12:31:26.600Z", "modified": "2020-11-30T08:42:55.516Z"}, {"entity": "publication", "iuid": "8c3b72858d46451ba01f4721713ac968", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8c3b72858d46451ba01f4721713ac968.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8c3b72858d46451ba01f4721713ac968"}}, "title": "European Hernia Society (EHS) guidance for the management of adult patients with a hernia during the COVID-19 pandemic.", "authors": [{"family": "Stabilini", "given": "C", "initials": "C"}, {"family": "East", "given": "B", "initials": "B"}, {"family": "Fortelny", "given": "R", "initials": "R"}, {"family": "Gillion", "given": "J-F", "initials": "J"}, {"family": "Lorenz", "given": "R", "initials": "R"}, {"family": "Montgomery", "given": "A", "initials": "A"}, {"family": "Morales-Conde", "given": "S", "initials": "S"}, {"family": "Muysoms", "given": "F", "initials": "F"}, {"family": "Pawlak", "given": "M", "initials": "M"}, {"family": "Reinpold", "given": "W", "initials": "W"}, {"family": "Simons", "given": "M", "initials": "M"}, {"family": "de Beaux", "given": "A C", "initials": "AC"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Hernia", "issn": "1248-9204", "issn-l": null, "volume": "24", "issue": "5", "pages": "977-983"}, "abstract": null, "doi": "10.1007/s10029-020-02212-8", "pmid": "32415652", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10029-020-02212-8"}, {"db": "pmc", "key": "PMC7227454"}], "notes": [], "created": "2020-12-10T08:53:10.937Z", "modified": "2020-12-11T14:19:18.837Z"}, {"entity": "publication", "iuid": "75c67caf246e413986c2d887261bb7d2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/75c67caf246e413986c2d887261bb7d2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/75c67caf246e413986c2d887261bb7d2"}}, "title": "Epidemic and pandemic viral infections: impact on tuberculosis and the lung: A consensus by the World Association for Infectious Diseases and Immunological Disorders (WAidid), Global Tuberculosis Network (GTN), and members of the European Society of Clinical Microbiology and Infectious Diseases Study Group for Mycobacterial Infections (ESGMYC).", "authors": [{"family": "Ong", "given": "Catherine Wei Min", "initials": "CWM"}, {"family": "Migliori", "given": "Giovanni Battista", "initials": "GB"}, {"family": "Raviglione", "given": "Mario", "initials": "M"}, {"family": "MacGregor-Skinner", "given": "Gavin", "initials": "G"}, {"family": "Sotgiu", "given": "Giovanni", "initials": "G"}, {"family": "Alffenaar", "given": "Jan-Willem", "initials": "JW"}, {"family": "Tiberi", "given": "Simon", "initials": "S"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Alonzi", "given": "Tonino", "initials": "T"}, {"family": "Archuleta", "given": "Sophia", "initials": "S"}, {"family": "Brusin", "given": "Sergio", "initials": "S"}, {"family": "Cambau", "given": "Emmanuelle", "initials": "E"}, {"family": "Capobianchi", "given": "Maria Rosaria", "initials": "MR"}, {"family": "Castilletti", "given": "Concetta", "initials": "C"}, {"family": "Centis", "given": "Rosella", "initials": "R"}, {"family": "Cirillo", "given": "Daniela M", "initials": "DM"}, {"family": "D'Ambrosio", "given": "Lia", "initials": "L"}, {"family": "Delogu", "given": "Giovanni", "initials": "G"}, {"family": "Esposito", "given": "Susanna M R", "initials": "SMR"}, {"family": "Figueroa", "given": "Jose", "initials": "J"}, {"family": "Friedland", "given": "Jon S", "initials": "JS"}, {"family": "Ho", "given": "Benjamin Choon Heng", "initials": "BCH"}, {"family": "Ippolito", "given": "Giuseppe", "initials": "G"}, {"family": "Jankovic", "given": "Mateja", "initials": "M"}, {"family": "Kim", "given": "Hannah Yejin", "initials": "HY"}, {"family": "Rosales Klintz", "given": "Senia", "initials": "S"}, {"family": "K\u00f6dm\u00f6n", "given": "Csaba", "initials": "C"}, {"family": "Lalle", "given": "Eleonora", "initials": "E"}, {"family": "Leo", "given": "Yee Sin", "initials": "YS"}, {"family": "Leung", "given": "Chi-Chiu", "initials": "CC"}, {"family": "M\u00e4rtson", "given": "Anne-Grete", "initials": "AG"}, {"family": "Melazzini", "given": "Mario Giovanni", "initials": "MG"}, {"family": "Najafi Fard", "given": "Saeid", "initials": "S"}, {"family": "Penttinen", "given": "Pasi", "initials": "P"}, {"family": "Petrone", "given": "Linda", "initials": "L"}, {"family": "Petruccioli", "given": "Elisa", "initials": "E"}, {"family": "Pontali", "given": "Emanuele", "initials": "E"}, {"family": "Saderi", "given": "Laura", "initials": "L"}, {"family": "Santin", "given": "Miguel", "initials": "M"}, {"family": "Spanevello", "given": "Antonio", "initials": "A"}, {"family": "van Crevel", "given": "Reinout", "initials": "R"}, {"family": "van der Werf", "given": "Marieke J", "initials": "MJ"}, {"family": "Visca", "given": "Dina", "initials": "D"}, {"family": "Viveiros", "given": "Miguel", "initials": "M"}, {"family": "Zellweger", "given": "Jean-Pierre", "initials": "JP"}, {"family": "Zumla", "given": "Alimuddin", "initials": "A"}, {"family": "Goletti", "given": "Delia", "initials": "D"}], "type": "consensus development conference", "published": "2020-10-00", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "volume": "56", "issue": "4", "issn-l": "0903-1936"}, "abstract": "Major epidemics, including some that qualify as pandemics, such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), HIV, influenza A (H1N1)pdm/09 and most recently COVID-19, affect the lung. Tuberculosis (TB) remains the top infectious disease killer, but apart from syndemic TB/HIV little is known regarding the interaction of viral epidemics and pandemics with TB. The aim of this consensus-based document is to describe the effects of viral infections resulting in epidemics and pandemics that affect the lung (MERS, SARS, HIV, influenza A (H1N1)pdm/09 and COVID-19) and their interactions with TB. A search of the scientific literature was performed. A writing committee of international experts including the European Centre for Disease Prevention and Control Public Health Emergency (ECDC PHE) team, the World Association for Infectious Diseases and Immunological Disorders (WAidid), the Global Tuberculosis Network (GTN), and members of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Mycobacterial Infections (ESGMYC) was established. Consensus was achieved after multiple rounds of revisions between the writing committee and a larger expert group. A Delphi process involving the core group of authors (excluding the ECDC PHE team) identified the areas requiring review/consensus, followed by a second round to refine the definitive consensus elements. The epidemiology and immunology of these viral infections and their interactions with TB are discussed with implications for diagnosis, treatment and prevention of airborne infections (infection control, viral containment and workplace safety). This consensus document represents a rapid and comprehensive summary on what is known on the topic.", "doi": "10.1183/13993003.01727-2020", "pmid": "32586885", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "13993003.01727-2020"}, {"db": "pmc", "key": "PMC7527651"}], "notes": [], "created": "2020-11-30T08:54:54.178Z", "modified": "2020-11-30T08:54:54.189Z"}, {"entity": "publication", "iuid": "3225f0c765e1457992c1dfecb0cc699e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3225f0c765e1457992c1dfecb0cc699e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3225f0c765e1457992c1dfecb0cc699e"}}, "title": "Effect of the COVID-19 pandemic response on intrapartum care, stillbirth, and neonatal mortality outcomes in Nepal: a prospective observational study.", "authors": [{"family": "Kc", "given": "Ashish", "initials": "A"}, {"family": "Gurung", "given": "Rejina", "initials": "R"}, {"family": "Kinney", "given": "Mary V", "initials": "MV"}, {"family": "Sunny", "given": "Avinash K", "initials": "AK"}, {"family": "Moinuddin", "given": "Md", "initials": "M"}, {"family": "Basnet", "given": "Omkar", "initials": "O"}, {"family": "Paudel", "given": "Prajwal", "initials": "P"}, {"family": "Bhattarai", "given": "Pratiksha", "initials": "P"}, {"family": "Subedi", "given": "Kalpana", "initials": "K"}, {"family": "Shrestha", "given": "Mahendra Prasad", "initials": "MP"}, {"family": "Lawn", "given": "Joy E", "initials": "JE"}, {"family": "M\u00e5lqvist", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Lancet Glob Health", "issn": "2214-109X", "issn-l": null, "volume": "8", "issue": "10", "pages": "e1273-e1281"}, "abstract": "The COVID-19 pandemic response is affecting maternal and neonatal health services all over the world. We aimed to assess the number of institutional births, their outcomes (institutional stillbirth and neonatal mortality rate), and quality of intrapartum care before and during the national COVID-19 lockdown in Nepal.\r\n\r\nIn this prospective observational study, we collected participant-level data for pregnant women enrolled in the SUSTAIN and REFINE studies between Jan 1 and May 30, 2020, from nine hospitals in Nepal. This period included 12\u00b75 weeks before the national lockdown and 9\u00b75 weeks during the lockdown. Women were eligible for inclusion if they had a gestational age of 22 weeks or more, a fetal heart sound at time of admission, and consented to inclusion. Women who had multiple births and their babies were excluded. We collected information on demographic and obstetric characteristics via extraction from case notes and health worker performance via direct observation by independent clinical researchers. We used regression analyses to assess changes in the number of institutional births, quality of care, and mortality before lockdown versus during lockdown.\r\n\r\nOf 22 907 eligible women, 21 763 women were enrolled and 20 354 gave birth, and health worker performance was recorded for 10 543 births. From the beginning to the end of the study period, the mean weekly number of births decreased from 1261\u00b71 births (SE 66\u00b71) before lockdown to 651\u00b74 births (49\u00b79) during lockdown-a reduction of 52\u00b74%. The institutional stillbirth rate increased from 14 per 1000 total births before lockdown to 21 per 1000 total births during lockdown (p=0\u00b70002), and institutional neonatal mortality increased from 13 per 1000 livebirths to 40 per 1000 livebirths (p=0\u00b70022). In terms of quality of care, intrapartum fetal heart rate monitoring decreased by 13\u00b74% (-15\u00b74 to -11\u00b73; p<0\u00b70001), and breastfeeding within 1 h of birth decreased by 3\u00b75% (-4\u00b76 to -2\u00b76; p=0\u00b70032). The immediate newborn care practice of placing the baby skin-to-skin with their mother increased by 13\u00b72% (12\u00b71 to 14\u00b75; p<0\u00b70001), and health workers' hand hygiene practices during childbirth increased by 12\u00b79% (11\u00b78 to 13\u00b79) during lockdown (p<0\u00b70001).\r\n\r\nInstitutional childbirth reduced by more than half during lockdown, with increases in institutional stillbirth rate and neonatal mortality, and decreases in quality of care. Some behaviours improved, notably hand hygiene and keeping the baby skin-to-skin with their mother. An urgent need exists to protect access to high quality intrapartum care and prevent excess deaths for the most vulnerable health system users during this pandemic period.\r\n\r\nGrand Challenges Canada.", "doi": "10.1016/S2214-109X(20)30345-4", "pmid": "32791117", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2214-109X(20)30345-4"}, {"db": "pmc", "key": "PMC7417164"}], "notes": [], "created": "2020-12-07T13:25:40.521Z", "modified": "2021-02-26T08:46:59.892Z"}, {"entity": "publication", "iuid": "8da6e2c62015459089ced85518bfb9cb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8da6e2c62015459089ced85518bfb9cb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8da6e2c62015459089ced85518bfb9cb"}}, "title": "Education for sustainable healthcare: Leadership to get from here to there.", "authors": [{"family": "McKimm", "given": "Judy", "initials": "J"}, {"family": "Redvers", "given": "Nicole", "initials": "N"}, {"family": "El Omrani", "given": "Omnia", "initials": "O"}, {"family": "Parkes", "given": "Margot W", "initials": "MW"}, {"family": "Elf", "given": "Marie", "initials": "M"}, {"family": "Woollard", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Med Teach", "issn": "1466-187X", "volume": "42", "issue": "10", "pages": "1123-1127", "issn-l": null}, "abstract": "The current global crises, including climate, COVID-19, and environmental change, requires global collective action at all scales. These broad socio-ecological challenges require the engagement of diverse perspectives and ways of knowing and the meaningful engagement of all generations and stages of personal and professional development. The combination of systems thinking, change management, quality improvement approaches and models, appreciative/strength-based approaches, narratives, storytelling and the strengths of Indigenous knowledges, offer synergies and potential that can set the stage for transformative, strengths-based education for sustainable healthcare (ESH). The need for strong leadership to enact a vision for ESH is outlined here with the intent to enable and nurture the conditions for change, ultimately improving health and well-being across generations.", "doi": "10.1080/0142159X.2020.1795104", "pmid": "32776858", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-07T13:32:42.469Z", "modified": "2020-12-07T13:32:42.488Z"}, {"entity": "publication", "iuid": "b15ba4b711654135a2ba50602ff79c98", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b15ba4b711654135a2ba50602ff79c98.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b15ba4b711654135a2ba50602ff79c98"}}, "title": "EXPOSED: An occupant exposure model for confined spaces to retrofit crowd models during a pandemic.", "authors": [{"family": "Ronchi", "given": "Enrico", "initials": "E"}, {"family": "Lovreglio", "given": "Ruggiero", "initials": "R"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Saf Sci", "issn": "0925-7535", "volume": "130", "issue": null, "pages": "104834", "issn-l": null}, "abstract": "Crowd models can be used for the simulation of people movement in the built environment. Crowd model outputs have been used for evaluating safety and comfort of pedestrians, inform crowd management and perform forensic investigations. Microscopic crowd models allow the representation of each person and the obtainment of information concerning their location over time and interactions with the physical space/other people. Pandemics such as COVID-19 have posed several questions on safe building usage, given the risk of disease transmission among building occupants. Here we show how crowd modelling can be used to assess occupant exposure in confined spaces. The policies adopted concerning building usage and social distancing during a pandemic can vary greatly, and they are mostly based on the macroscopic analysis of the spread of disease rather than a safety assessment performed at a building level. The proposed model allows the investigation of occupant exposure in buildings based on the analysis of microscopic people movement. Risk assessment is performed by retrofitting crowd models with a universal model for exposure assessment which can account for different types of disease transmissions. This work allows policy makers to perform informed decisions concerning building usage during a pandemic.", "doi": "10.1016/j.ssci.2020.104834", "pmid": "32834509", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0925-7535(20)30231-9"}, {"db": "pii", "key": "104834"}, {"db": "pmc", "key": "PMC7373681"}], "notes": [], "created": "2020-12-07T11:44:35.957Z", "modified": "2020-12-07T11:44:35.981Z"}, {"entity": "publication", "iuid": "171bcce7a979419cb54729a50448495c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/171bcce7a979419cb54729a50448495c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/171bcce7a979419cb54729a50448495c"}}, "title": "Dying From COVID-19: Loneliness, End-of-Life Discussions, and Support for Patients and Their Families in Nursing Homes and Hospitals. A National Register Study.", "authors": [{"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "Bergstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Martinsson", "given": "Lisa", "initials": "L"}, {"family": "Lundstr\u00f6m", "given": "Staffan", "initials": "S"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "J Pain Symptom Manage", "issn": "1873-6513", "issn-l": null, "volume": "60", "issue": "4", "pages": "e2-e13"}, "abstract": "Preparation for an impending death through end-of-life (EOL) discussions and human presence when a person is dying is important for both patients and families.\r\n\r\nThe aim was to study whether EOL discussions were offered and to what degree patients were alone at time of death when dying from coronavirus disease 2019 (COVID-19), comparing deaths in nursing homes and hospitals.\r\n\r\nThe national Swedish Register of Palliative Care was used. All expected deaths from COVID-19 in nursing homes and hospitals were compared with, and contrasted to, deaths in a reference population (deaths in 2019).\r\n\r\nA total of 1346 expected COVID-19 deaths in nursing homes (n = 908) and hospitals (n = 438) were analyzed. Those who died were of a more advanced age in nursing homes (mean 86.4 years) and of a lower age in hospitals (mean 80.7 years) (P < 0.0001). Fewer EOL discussions with patients were held compared with deaths in 2019 (74% vs. 79%, P < 0.001), and dying with someone present was much more uncommon (59% vs. 83%, P < 0.0001). In comparisons between nursing homes and hospital deaths, more patients dying in nursing homes were women (56% vs. 37%, P < 0.0001), and significantly fewer had a retained ability to express their will during the last week of life (54% vs. 89%, P < 0.0001). Relatives were present at time of death in only 13% and 24% of the cases in nursing homes and hospitals, respectively (P < 0.001). The corresponding figures for staff were 52% and 38% (P < 0.0001).\r\n\r\nDying from COVID-19 negatively affects the possibility of holding an EOL discussion and the chances of dying with someone present. This has considerable social and existential consequences for both patients and families.", "doi": "10.1016/j.jpainsymman.2020.07.020", "pmid": "32721500", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0885-3924(20)30630-8"}, {"db": "pmc", "key": "PMC7382350"}], "notes": [], "created": "2020-12-07T16:09:21.631Z", "modified": "2022-11-09T09:09:59.506Z"}, {"entity": "publication", "iuid": "abaafb213d3642919cb71f28b80149e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abaafb213d3642919cb71f28b80149e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abaafb213d3642919cb71f28b80149e7"}}, "title": "Dealing with uncertainty after transplantation in times of COVID-19.", "authors": [{"family": "Massey", "given": "Emma K", "initials": "EK"}, {"family": "Forsberg", "given": "Anna", "initials": "A"}], "type": "letter", "published": "2020-10-00", "journal": {"title": "Transpl Int", "issn": "1432-2277", "volume": "33", "issue": "10", "pages": "1337-1338", "issn-l": null}, "abstract": null, "doi": "10.1111/tri.13709", "pmid": "32725696", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-07T16:08:11.914Z", "modified": "2020-12-07T16:08:30.213Z"}, {"entity": "publication", "iuid": "5cfabeea139c408f8f4fab4b47469ca0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5cfabeea139c408f8f4fab4b47469ca0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5cfabeea139c408f8f4fab4b47469ca0"}}, "title": "Dataset of knowledge, attitude, practices and psychological implications of healthcare workers in Pakistan during COVID-19 pandemic.", "authors": [{"family": "Qasim", "given": "Muhammad", "initials": "M"}, {"family": "Awan", "given": "Usman Ayub", "initials": "UA"}, {"family": "Afzal", "given": "Muhammad Sohail", "initials": "MS"}, {"family": "Saqib", "given": "Muhammad Arif Nadeem", "initials": "MAN"}, {"family": "Siddiqui", "given": "Shajee", "initials": "S"}, {"family": "Ahmed", "given": "Haroon", "initials": "H"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Data Brief", "issn": "2352-3409", "issn-l": null, "volume": "32", "issue": null, "pages": "106234"}, "abstract": "The COVID-19 pandemic has created a global health emergency and has a huge impact on the health care workers, especially on their mental health. The dataset presented was an assessment of COVID-19 related knowledge, attitude, practices and its effects on the mental health of frontline healthcare workers in Pakistan. The data were collected using a snowball sampling technique. A questionnaire was developed assessing sociodemographic characteristics (6 items), knowledge (11 items), attitude (5 items), practices (6 items), information sources (1 item) and psychological implications (12 items) and distributed using online tools. The dataset includes 476 healthcare workers in Pakistan. The dataset will help to prevent and curb the spread of COVID-19 among health workers and contribute to policymakers. Furthermore, our dataset provides detailed insights into different risk factors of psychological problems, and it may be served as the reference for various in-depth surveys.", "doi": "10.1016/j.dib.2020.106234", "pmid": "32895632", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S2352-3409(20)31128-8"}, {"db": "pii", "key": "106234"}, {"db": "pmc", "key": "PMC7462453"}], "notes": [], "created": "2020-12-06T07:21:44.969Z", "modified": "2022-11-09T09:10:37.633Z"}, {"entity": "publication", "iuid": "4796c127b3264e32a6831ad545b0ff92", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4796c127b3264e32a6831ad545b0ff92.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4796c127b3264e32a6831ad545b0ff92"}}, "title": "Comprehensive investigation of an in-hospital transmission cluster of a symptomatic SARS-CoV-2-positive physician among patients and healthcare workers in Germany.", "authors": [{"family": "Wendt", "given": "Ralph", "initials": "R"}, {"family": "Nagel", "given": "Stephan", "initials": "S"}, {"family": "Nickel", "given": "Olaf", "initials": "O"}, {"family": "Wolf", "given": "Johannes", "initials": "J"}, {"family": "Kalbitz", "given": "Sven", "initials": "S"}, {"family": "Kaiser", "given": "Thorsten", "initials": "T"}, {"family": "Borte", "given": "Stephan", "initials": "S"}, {"family": "L\u00fcbbert", "given": "Christoph", "initials": "C"}], "type": "case reports", "published": "2020-10-00", "journal": {"title": "Infect Control Hosp Epidemiol", "issn": "1559-6834", "volume": "41", "issue": "10", "pages": "1209-1211", "issn-l": "0899-823X"}, "abstract": "We investigated potential transmissions of a symptomatic SARS-CoV-2-positive physician in a tertiary-care hospital who worked for 15 cumulative hours without wearing a face mask. No in-hospital transmissions occurred, despite 254 contacts among patients and healthcare workers. In conclusion, exposed hospital staff continued work, accompanied by close clinical and virologic monitoring.", "doi": "10.1017/ice.2020.268", "pmid": "32489162", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0899823X20002688"}, {"db": "pmc", "key": "PMC7298077"}], "notes": [], "created": "2020-11-25T09:41:22.284Z", "modified": "2021-02-26T08:45:48.105Z"}, {"entity": "publication", "iuid": "85157ee446f24772b44d5e9ac2539b9e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/85157ee446f24772b44d5e9ac2539b9e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/85157ee446f24772b44d5e9ac2539b9e"}}, "title": "Clarifications on Technologies to Optimize Care of Severe COVID-19 Patients.", "authors": [{"family": "Brull", "given": "Sorin J", "initials": "SJ"}, {"family": "Kopman", "given": "Aaron F", "initials": "AF"}], "type": "letter", "published": "2020-10-00", "journal": {"title": "Anesth Analg", "issn": "1526-7598", "volume": "131", "issue": "4", "pages": "e192-e193", "issn-l": null}, "abstract": null, "doi": "10.1213/ANE.0000000000005120", "pmid": "32665462", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7365583"}], "notes": [], "created": "2020-12-07T16:38:42.283Z", "modified": "2020-12-07T16:38:42.308Z"}, {"entity": "publication", "iuid": "0d54d30ef4aa4861a056b01048b810d1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d54d30ef4aa4861a056b01048b810d1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d54d30ef4aa4861a056b01048b810d1"}}, "title": "COVID-19, Mental Health, and Religious Coping Among American Orthodox Jews.", "authors": [{"family": "Pirutinsky", "given": "Steven", "initials": "S"}, {"family": "Cherniak", "given": "Aaron D", "initials": "AD"}, {"family": "Rosmarin", "given": "David H", "initials": "DH"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "J Relig Health", "issn": "1573-6571", "issn-l": null, "volume": "59", "issue": "5", "pages": "2288-2301"}, "abstract": "The COVID-19 pandemic presents potential mental health challenges, and the American Orthodox Jewish population has been particularly affected by the virus. The current study assessed the impact of the pandemic and explored the relationships between exposure, religiosity, and distress in a sample of n = 419 American Orthodox Jews. Results indicated high levels of exposure, concern, and compliance with medical guidelines; however stress was generally low and we found evidence for positive impact. Direct exposure correlated with higher religiosity. Positive religious coping, intrinsic religiosity and trust in God strongly correlated with less stress and more positive impact, while negative religious coping and mistrust in God correlated with the inverse. While the study is limited by its design, findings highlight that for some, faith may promote resilience especially during crisis.", "doi": "10.1007/s10943-020-01070-z", "pmid": "32705481", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10943-020-01070-z"}, {"db": "pmc", "key": "PMC7377309"}], "notes": [], "created": "2020-12-07T16:20:30.936Z", "modified": "2022-11-09T09:11:03.183Z"}, {"entity": "publication", "iuid": "5631ba3e9abe4a2c85c782382fa3aa01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5631ba3e9abe4a2c85c782382fa3aa01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5631ba3e9abe4a2c85c782382fa3aa01"}}, "title": "COVID-19 and the brain: impact on nuclear medicine in neurology.", "authors": [{"family": "Morbelli", "given": "Silvia", "initials": "S"}, {"family": "Ekmekcioglu", "given": "Ozgul", "initials": "O"}, {"family": "Barthel", "given": "Henryk", "initials": "H"}, {"family": "Albert", "given": "Nathalie L", "initials": "NL"}, {"family": "Boellaard", "given": "Ronald", "initials": "R"}, {"family": "Cecchin", "given": "Diego", "initials": "D"}, {"family": "Guedj", "given": "Eric", "initials": "E"}, {"family": "Lammertsma", "given": "Adriaan A", "initials": "AA"}, {"family": "Law", "given": "Ian", "initials": "I"}, {"family": "Penuelas", "given": "Ivan", "initials": "I"}, {"family": "Semah", "given": "Franck", "initials": "F"}, {"family": "Traub-Weidinger", "given": "Tatjana", "initials": "T"}, {"family": "van de Giessen", "given": "Elsmarieke", "initials": "E"}, {"family": "Varrone", "given": "Andrea", "initials": "A"}, {"family": "Garibotto", "given": "Valentina", "initials": "V"}, {"family": "EANM Neuroimaging Committee", "given": "", "initials": ""}], "type": "editorial", "published": "2020-10-00", "journal": {"title": "Eur J Nucl Med Mol Imaging", "issn": "1619-7089", "volume": "47", "issue": "11", "pages": "2487-2492", "issn-l": null}, "abstract": null, "doi": "10.1007/s00259-020-04965-x", "pmid": "32700058", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00259-020-04965-x"}, {"db": "pmc", "key": "PMC7375837"}], "notes": [], "created": "2020-12-07T16:22:42.972Z", "modified": "2020-12-07T16:22:42.994Z"}, {"entity": "publication", "iuid": "22760662d260465e845d059e37f99921", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/22760662d260465e845d059e37f99921.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/22760662d260465e845d059e37f99921"}}, "title": "COVID-19 and mental health among older people in Sweden.", "authors": [{"family": "Skoog", "given": "Ingmar", "initials": "I"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Int Psychogeriatr", "issn": "1741-203X", "volume": "32", "issue": "10", "pages": "1173-1175", "issn-l": null}, "abstract": null, "doi": "10.1017/S104161022000143X", "pmid": "32635950", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S104161022000143X"}, {"db": "pmc", "key": "PMC7403743"}], "notes": [], "created": "2020-12-08T14:34:03.903Z", "modified": "2020-12-08T14:34:03.926Z"}, {"entity": "publication", "iuid": "6bb2344e298d441e9b2aa29db8f34878", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6bb2344e298d441e9b2aa29db8f34878.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6bb2344e298d441e9b2aa29db8f34878"}}, "title": "Build back stronger universal health coverage systems after the COVID-19 pandemic: the need for better governance and linkage with universal social protection.", "authors": [{"family": "Tediosi", "given": "Fabrizio", "initials": "F"}, {"family": "L\u00f6nnroth", "given": "Knut", "initials": "K"}, {"family": "Pablos-M\u00e9ndez", "given": "Ariel", "initials": "A"}, {"family": "Raviglione", "given": "Mario", "initials": "M"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "issn-l": "2059-7908", "volume": "5", "issue": "10", "pages": null}, "abstract": "Commentary", "doi": "10.1136/bmjgh-2020-004020", "pmid": "33122298", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-004020"}, {"db": "pmc", "key": "PMC7597511"}], "notes": [], "created": "2020-11-27T10:19:52.601Z", "modified": "2022-11-09T09:12:02.304Z"}, {"entity": "publication", "iuid": "be2ebedd6233495a88eb38cb95b66764", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/be2ebedd6233495a88eb38cb95b66764.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/be2ebedd6233495a88eb38cb95b66764"}}, "title": "Assessing the fear of COVID-19 among different populations: A response to Ransing et al. (2020).", "authors": [{"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Chang", "given": "Kun-Chia", "initials": "KC"}, {"family": "Chen", "given": "Yu-Pin", "initials": "YP"}, {"family": "Kuo", "given": "Yi-Jie", "initials": "YJ"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}], "type": "letter", "published": "2020-10-00", "journal": {"title": "Brain Behav Immun", "issn": "1090-2139", "volume": "89", "issue": null, "pages": "524-525", "issn-l": null}, "abstract": null, "doi": "10.1016/j.bbi.2020.06.006", "pmid": "32512132", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0889-1591(20)31198-3"}, {"db": "pmc", "key": "PMC7274088"}], "notes": [], "created": "2020-12-09T10:33:23.328Z", "modified": "2020-12-09T10:33:23.350Z"}, {"entity": "publication", "iuid": "d1bb3e2646f840f3bacba6c587c03e3a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1bb3e2646f840f3bacba6c587c03e3a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1bb3e2646f840f3bacba6c587c03e3a"}}, "title": "Advocacy for the human rights of older people in the COVID pandemic and beyond: a call to mental health professionals.", "authors": [{"family": "Peisah", "given": "Carmelle", "initials": "C"}, {"family": "Byrnes", "given": "Andrew", "initials": "A"}, {"family": "Doron", "given": "Israel Issi", "initials": "II"}, {"family": "Dark", "given": "Michael", "initials": "M"}, {"family": "Quinn", "given": "Gerard", "initials": "G"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Int Psychogeriatr", "issn": "1741-203X", "issn-l": null, "volume": "32", "issue": "10", "pages": "1199-1204"}, "abstract": null, "doi": "10.1017/S1041610220001076", "pmid": "32487280", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1041610220001076"}, {"db": "pmc", "key": "PMC7302948"}], "notes": [], "created": "2020-12-09T10:53:49.868Z", "modified": "2020-12-11T12:49:56.181Z"}, {"entity": "publication", "iuid": "3ae6115f8aed497694523e954dd74313", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ae6115f8aed497694523e954dd74313.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ae6115f8aed497694523e954dd74313"}}, "title": "Adaptation of evidence-based suicide prevention strategies during and after the COVID-19 pandemic.", "authors": [{"family": "Wasserman", "given": "Danuta", "initials": "D"}, {"family": "Iosue", "given": "Miriam", "initials": "M"}, {"family": "Wuestefeld", "given": "Anika", "initials": "A"}, {"family": "Carli", "given": "Vladimir", "initials": "V"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "World Psychiatry", "issn": "1723-8617", "volume": "19", "issue": "3", "pages": "294-306", "issn-l": null}, "abstract": "Suicide is preventable. Nevertheless, each year 800,000 people die of suicide in the world. While there is evidence indicating that suicide rates de-crease during times of crises, they are expected to increase once the immediate crisis has passed. The COVID-19 pandemic affects risk and pro-tective factors for suicide at each level of the socio-ecological model. Economic downturn, augmented barriers to accessing health care, increased access to suicidal means, inappropriate media reporting at the societal level; deprioritization of mental health and preventive activities at the community level; interpersonal conflicts, neglect and violence at the relationship level; unemployment, poverty, loneliness and hopelessness at the individual level: all these variables contribute to an increase of depression, anxiety, post-traumatic stress disorder, harmful use of alcohol, substance abuse, and ultimately suicide risk. Suicide should be prevented by strengthening universal strategies directed to the entire population, including mitigation of unemployment, poverty and inequalities; prioritization of access to mental health care; responsible media reporting, with information about available support; prevention of increased alcohol intake; and restriction of access to lethal means of suicide. Selective interventions should continue to target known vulnerable groups who are socio-economically disadvantaged, but also new ones such as first responders and health care staff, and the bereaved by COVID-19 who have been deprived of the final contact with loved ones and funerals. Indicated preventive strategies targeting individuals who display suicidal behaviour should focus on available pharmacological and psychological treatments of mental disorders, ensuring proper follow-up and chain of care by increased use of telemedicine and other digital means. The scientific community, health care professionals, politicians and decision-makers will find in this paper a systematic description of the effects of the pandemic on suicide risk at the society, community, family and individual levels, and an overview of how evidence-based suicide preventive interventions should be adapted. Research is needed to investigate which adaptations are effective and in which con-texts.", "doi": "10.1002/wps.20801", "pmid": "32931107", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7491639"}], "notes": [], "created": "2020-12-03T15:34:27.996Z", "modified": "2020-12-03T15:34:28.019Z"}, {"entity": "publication", "iuid": "c6465dd934734f92a6dcc63a323d6953", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c6465dd934734f92a6dcc63a323d6953.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c6465dd934734f92a6dcc63a323d6953"}}, "title": "ATMO-vent: An adapted breathing atmosphere for COVID-19 patients.", "authors": [{"family": "Mathanlal", "given": "Thasshwin", "initials": "T"}, {"family": "Israel Nazarious", "given": "Miracle", "initials": "M"}, {"family": "Mantas-Nakhai", "given": "Roberto", "initials": "R"}, {"family": "Zorzano", "given": "Maria-Paz", "initials": "MP"}, {"family": "Martin-Torres", "given": "Javier", "initials": "J"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "HardwareX", "issn": "2468-0672", "volume": "8", "issue": null, "pages": "e00145", "issn-l": null}, "abstract": "The ongoing worldwide pandemic of coronavirus disease 2019 (COVID-19), has been one of the most significant challenges to humankind in centuries. The extremely contagious nature of the SARS-CoV-2 virus has put forth an immense pressure on the health sector. In order to mitigate the stress on the healthcare systems especially to battle the crisis of mechanical ventilators, we have designed a modular, and robust DIY ventilator, ATMO-Vent (Atmospheric Mixture Optimization Ventilator) which can be fully mounted within two days by two operators. The ATMO-Vent has been designed using low-cost, robust, Commercial Off The Shelf (COTS) components, with many features comparable to a full-fledged ventilator. ATMO-Vent has been designed based on the United Kingdom Medicines & Healthcare products Regulatory Agency (UK-MHRA) guidelines for Rapidly Manufactured Ventilator System (RMVS), yet is scalable to the specific requirements of different countries. ATMO-Vent is capable of adjusting the Fraction of Inspiratory Oxygen (FiO 2) levels, Tidal Volume (TV), frequency of breaths, Inspiratory/Expiratory ratio (I/E), Peak Inspiratory Pressure (PIP) and Positive End-Expiratory Pressure (PEEP). ATMO-Vent can operate in two modes - Continuous Mandatory Ventilation (CMV) using Volume-Controlled Ventilation (VCV) and in Assisted Control (AC) mode with pressure triggered by the patient. ATMO-Vent has undergone rigorous testing and qualifies under Class B Electric and Magnetic Compatibility (EMC) requirements of EN 55,011 CISPR 11 standards.", "doi": "10.1016/j.ohx.2020.e00145", "pmid": "33015423", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2468-0672(20)30054-7"}, {"db": "pmc", "key": "PMC7518965"}], "notes": [], "created": "2020-12-03T08:52:38.086Z", "modified": "2020-12-03T08:52:38.097Z"}, {"entity": "publication", "iuid": "96f7ca266c114d4094a654bf661590b2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/96f7ca266c114d4094a654bf661590b2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/96f7ca266c114d4094a654bf661590b2"}}, "title": "A compendium answering 150 questions on COVID-19 and SARS-CoV-2.", "authors": [{"family": "Riggioni", "given": "Carmen", "initials": "C"}, {"family": "Comberiati", "given": "Pasquale", "initials": "P"}, {"family": "Giovannini", "given": "Mattia", "initials": "M"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Akdis", "given": "M\u00fcbeccel", "initials": "M"}, {"family": "Alves-Correia", "given": "Magna", "initials": "M"}, {"family": "Ant\u00f3", "given": "Josep M", "initials": "JM"}, {"family": "Arcolaci", "given": "Alessandra", "initials": "A"}, {"family": "Azkur", "given": "Ahmet Kursat", "initials": "AK"}, {"family": "Azkur", "given": "Dilek", "initials": "D"}, {"family": "Beken", "given": "Burcin", "initials": "B"}, {"family": "Boccabella", "given": "Cristina", "initials": "C"}, {"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Breiteneder", "given": "Heimo", "initials": "H"}, {"family": "Carvalho", "given": "Daniela", "initials": "D"}, {"family": "De Las Vecillas", "given": "Leticia", "initials": "L"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}, {"family": "Eguiluz-Gracia", "given": "Ibon", "initials": "I"}, {"family": "Eiwegger", "given": "Thomas", "initials": "T"}, {"family": "Eyerich", "given": "Stefanie", "initials": "S"}, {"family": "Fokkens", "given": "Wytske", "initials": "W"}, {"family": "Gao", "given": "Ya-Dong", "initials": "YD"}, {"family": "Hannachi", "given": "Farah", "initials": "F"}, {"family": "Johnston", "given": "Sebastian L", "initials": "SL"}, {"family": "Jutel", "given": "Marek", "initials": "M"}, {"family": "Karavelia", "given": "Aspasia", "initials": "A"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Moya", "given": "Beatriz", "initials": "B"}, {"family": "Nadeau", "given": "Kari C", "initials": "KC"}, {"family": "O'Hehir", "given": "Robyn", "initials": "R"}, {"family": "O'Mahony", "given": "Liam", "initials": "L"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Sanak", "given": "Marek", "initials": "M"}, {"family": "Schwarze", "given": "J\u00fcrgen", "initials": "J"}, {"family": "Sokolowska", "given": "Milena", "initials": "M"}, {"family": "Torres", "given": "Mar\u00eda J", "initials": "MJ"}, {"family": "van de Veen", "given": "Willem", "initials": "W"}, {"family": "van Zelm", "given": "Menno C", "initials": "MC"}, {"family": "Wang", "given": "De Yun", "initials": "Y"}, {"family": "Zhang", "given": "Luo", "initials": "L"}, {"family": "Jim\u00e9nez-Saiz", "given": "Rodrigo", "initials": "R"}, {"family": "Akdis", "given": "Cezmi A", "initials": "CA"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": "75", "issue": "10", "pages": "2503-2541", "issn-l": "0105-4538"}, "abstract": "In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date, it has resulted in ~9 million confirmed cases and caused almost 500 000 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socioeconomic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19. Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a \"cytokine storm\" leading to acute respiratory distress syndrome, endothelitis, thromboembolic complications, and multiorgan failure. The epidemiologic features of COVID-19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID-19-related topics should be based on more coordinated high-quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19, and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development, and epidemiology. A total of 150 questions were answered by experts in the field providing a comprehensive and practical overview of COVID-19 and allergic disease.", "doi": "10.1111/all.14449", "pmid": "32535955", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7323196"}], "notes": [], "created": "2020-11-30T09:00:22.912Z", "modified": "2020-11-30T09:00:22.921Z"}, {"entity": "publication", "iuid": "ef2d70107eb54e599739267f1d63e241", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ef2d70107eb54e599739267f1d63e241.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ef2d70107eb54e599739267f1d63e241"}}, "title": "A commentary on \"The trouble with trust: Time-series analysis of social capital, income inequality, and COVID-19 deaths in 84 countries\".", "authors": [{"family": "Lindstr\u00f6m", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Soc Sci Med", "issn": "1873-5347", "issn-l": null, "volume": "263", "issue": null, "pages": "113386"}, "abstract": "Comment\r\nThis study investigates associations between central aspects of social capital (social trust, group affiliations, civic engagement, confidence in state institutions), income inequality (Gini index for income), and COVID-19 mortality in 84 countries included in different time waves of the World Values Survey (WVS) (Elgar et al., 2020). Comments: First, infectious diseases are either patterned according to socioeconomic status (SES), determined by e.g. habitus, nutrition and crowded housing or clustering, or not according to SES. Second, the focus on economic inequality measured as income inequality (Gini index) should be complemented with measures of wealth inequality (Gini index for wealth), following the globalization process with tax exempted multinational companies. Third, the aspects of social capital were measured in different time waves of the World Values Survey (WVS) for different countries, which is a weakness because trust and other aspects of social capital vary over time and depend on specific events and social and economic trends.", "doi": "10.1016/j.socscimed.2020.113386", "pmid": "33036797", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0277-9536(20)30605-5"}, {"db": "pmc", "key": "PMC7532747"}], "notes": [], "created": "2020-12-01T17:26:58.810Z", "modified": "2020-12-01T17:27:46.293Z"}, {"entity": "publication", "iuid": "37842769c6394a15b1f9ad6e57ec202a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/37842769c6394a15b1f9ad6e57ec202a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/37842769c6394a15b1f9ad6e57ec202a"}}, "title": "Updated guidance on the management of COVID-19: from an American Thoracic Society/European Respiratory Society coordinated International Task Force (29 July 2020).", "authors": [{"family": "Bai", "given": "Chunxue", "initials": "C"}, {"family": "Chotirmall", "given": "Sanjay H", "initials": "SH"}, {"family": "Rello", "given": "Jordi", "initials": "J"}, {"family": "Alba", "given": "George A", "initials": "GA"}, {"family": "Ginns", "given": "Leo C", "initials": "LC"}, {"family": "Krishnan", "given": "Jerry A", "initials": "JA"}, {"family": "Rogers", "given": "Robert", "initials": "R"}, {"family": "Bendstrup", "given": "Elisabeth", "initials": "E"}, {"family": "Burgel", "given": "Pierre-Regis", "initials": "PR"}, {"family": "Chalmers", "given": "James D", "initials": "JD"}, {"family": "Chua", "given": "Abigail", "initials": "A"}, {"family": "Crothers", "given": "Kristina A", "initials": "KA"}, {"family": "Duggal", "given": "Abhijit", "initials": "A"}, {"family": "Kim", "given": "Yeon Wook", "initials": "YW"}, {"family": "Laffey", "given": "John G", "initials": "JG"}, {"family": "Luna", "given": "Carlos M", "initials": "CM"}, {"family": "Niederman", "given": "Michael S", "initials": "MS"}, {"family": "Raghu", "given": "Ganesh", "initials": "G"}, {"family": "Ramirez", "given": "Julio A", "initials": "JA"}, {"family": "Riera", "given": "Jordi", "initials": "J"}, {"family": "Roca", "given": "Oriol", "initials": "O"}, {"family": "Tamae-Kakazu", "given": "Maximiliano", "initials": "M"}, {"family": "Torres", "given": "Antoni", "initials": "A"}, {"family": "Watkins", "given": "Richard R", "initials": "RR"}, {"family": "Barrecheguren", "given": "Miriam", "initials": "M"}, {"family": "Belliato", "given": "Mirko", "initials": "M"}, {"family": "Chami", "given": "Hassan A", "initials": "HA"}, {"family": "Chen", "given": "Rongchang", "initials": "R"}, {"family": "Cortes-Puentes", "given": "Gustavo A", "initials": "GA"}, {"family": "Delacruz", "given": "Charles", "initials": "C"}, {"family": "Hayes", "given": "Margaret M", "initials": "MM"}, {"family": "Heunks", "given": "Leo M A", "initials": "LMA"}, {"family": "Holets", "given": "Steven R", "initials": "SR"}, {"family": "Hough", "given": "Catherine L", "initials": "CL"}, {"family": "Jagpal", "given": "Sugeet", "initials": "S"}, {"family": "Jeon", "given": "Kyeongman", "initials": "K"}, {"family": "Johkoh", "given": "Takeshi", "initials": "T"}, {"family": "Lee", "given": "May M", "initials": "MM"}, {"family": "Liebler", "given": "Janice", "initials": "J"}, {"family": "McElvaney", "given": "Gerry N", "initials": "GN"}, {"family": "Moskowitz", "given": "Ari", "initials": "A"}, {"family": "Oeckler", "given": "Richard A", "initials": "RA"}, {"family": "Ojanguren", "given": "I\u00f1igo", "initials": "I"}, {"family": "O'Regan", "given": "Anthony", "initials": "A"}, {"family": "Pletz", "given": "Mathias W", "initials": "MW"}, {"family": "Rhee", "given": "Chin Kook", "initials": "CK"}, {"family": "Schultz", "given": "Marcus J", "initials": "MJ"}, {"family": "Storti", "given": "Enrico", "initials": "E"}, {"family": "Strange", "given": "Charlie", "initials": "C"}, {"family": "Thomson", "given": "Carey C", "initials": "CC"}, {"family": "Torriani", "given": "Francesca J", "initials": "FJ"}, {"family": "Wang", "given": "Xun", "initials": "X"}, {"family": "Wuyts", "given": "Wim", "initials": "W"}, {"family": "Xu", "given": "Tao", "initials": "T"}, {"family": "Yang", "given": "Dawei", "initials": "D"}, {"family": "Zhang", "given": "Ziqiang", "initials": "Z"}, {"family": "Wilson", "given": "Kevin C", "initials": "KC"}], "type": "journal article", "published": "2020-09-30", "journal": {"title": "Eur Respir Rev", "issn": "1600-0617", "volume": "29", "issue": "157", "issn-l": "0905-9180"}, "abstract": "Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome-coronavirus-2. Consensus suggestions can standardise care, thereby improving outcomes and facilitating future research.\n\nAn International Task Force was composed and agreement regarding courses of action was measured using the Convergence of Opinion on Recommendations and Evidence (CORE) process. 70% agreement was necessary to make a consensus suggestion.\n\nThe Task Force made consensus suggestions to treat patients with acute COVID-19 pneumonia with remdesivir and dexamethasone but suggested against hydroxychloroquine except in the context of a clinical trial; these are revisions of prior suggestions resulting from the interim publication of several randomised trials. It also suggested that COVID-19 patients with a venous thromboembolic event be treated with therapeutic anticoagulant therapy for 3 months. The Task Force was unable to reach sufficient agreement to yield consensus suggestions for the post-hospital care of COVID-19 survivors. The Task Force fell one vote shy of suggesting routine screening for depression, anxiety and post-traumatic stress disorder.\n\nThe Task Force addressed questions related to pharmacotherapy in patients with COVID-19 and the post-hospital care of survivors, yielding several consensus suggestions. Management options for which there is insufficient agreement to formulate a suggestion represent research priorities.", "doi": "10.1183/16000617.0287-2020", "pmid": "33020069", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "29/157/200287"}, {"db": "pmc", "key": "PMC7537943"}], "notes": [], "created": "2020-11-27T12:39:01.420Z", "modified": "2020-11-27T12:39:01.445Z"}, {"entity": "publication", "iuid": "2e68cc9fd8374ee184f801694fbe140c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e68cc9fd8374ee184f801694fbe140c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e68cc9fd8374ee184f801694fbe140c"}}, "title": "The major genetic risk factor for severe COVID-19 is inherited from Neanderthals.", "authors": [{"family": "Zeberg", "given": "Hugo", "initials": "H"}, {"family": "P\u00e4\u00e4bo", "given": "Svante", "initials": "S"}], "type": "journal article", "published": "2020-09-30", "journal": {"title": "Nature", "issn": "1476-4687", "issn-l": "0028-0836", "volume": "587", "issue": "7835", "pages": "610-612"}, "abstract": "A recent genetic association study 1 identified a gene cluster on chromosome 3 as a risk locus for respiratory failure after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A separate study (COVID-19 Host Genetics Initiative)2 comprising 3,199 hospitalized patients with coronavirus disease 2019 (COVID-19) and control individuals showed that this cluster is the major genetic risk factor for severe symptoms after SARS-CoV-2 infection and hospitalization. Here we show that the risk is conferred by a genomic segment of around 50 kilobases in size that is inherited from Neanderthals and is carried by around 50% of people in south Asia and around 16% of people in Europe.", "doi": "10.1038/s41586-020-2818-3", "pmid": "32998156", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41586-020-2818-3"}, {"db": "URL", "key": "http://genome.ucsc.edu/cgi-bin/hgTrackUi?db=hg38&g=covidHgiGwas", "description": "COVID-19 Host Genetics Initiative (round 3, ANA_B2_V2):  summary statistics of the genome-wide association study"}, {"db": "NA", "key": "Genetic information used in the study are available in public repositories (e.g. http://cdna.eva.mpg.de/neandertal/)", "description": null}], "notes": [], "created": "2020-11-18T17:00:53.715Z", "modified": "2021-11-18T09:10:47.724Z"}, {"entity": "publication", "iuid": "450e8ebbae3a45899766c71e26df149c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/450e8ebbae3a45899766c71e26df149c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/450e8ebbae3a45899766c71e26df149c"}}, "title": "Innate Immune Responses to Acute Viral Infection During Pregnancy.", "authors": [{"family": "Cornish", "given": "Emily F", "initials": "EF"}, {"family": "Filipovic", "given": "Iva", "initials": "I"}, {"family": "\u00c5senius", "given": "Fredrika", "initials": "F"}, {"family": "Williams", "given": "David J", "initials": "DJ"}, {"family": "McDonnell", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2020-09-30", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "11", "issue": null, "pages": "572567", "issn-l": "1664-3224"}, "abstract": "Immunological adaptations in pregnancy allow maternal tolerance of the semi-allogeneic fetus but also increase maternal susceptibility to infection. At implantation, the endometrial stroma, glands, arteries and immune cells undergo anatomical and functional transformation to create the decidua, the specialized secretory endometrium of pregnancy. The maternal decidua and the invading fetal trophoblast constitute a dynamic junction that facilitates a complex immunological dialogue between the two. The decidual and peripheral immune systems together assume a pivotal role in regulating the critical balance between tolerance and defense against infection. Throughout pregnancy, this equilibrium is repeatedly subjected to microbial challenge. Acute viral infection in pregnancy is associated with a wide spectrum of adverse consequences for both mother and fetus. Vertical transmission from mother to fetus can cause developmental anomalies, growth restriction, preterm birth and stillbirth, while the mother is predisposed to heightened morbidity and maternal death. A rapid, effective response to invasive pathogens is therefore essential in order to avoid overwhelming maternal infection and consequent fetal compromise. This sentinel response is mediated by the innate immune system: a heritable, highly evolutionarily conserved system comprising physical barriers, antimicrobial peptides (AMP) and a variety of immune cells-principally neutrophils, macrophages, dendritic cells, and natural killer cells-which express pattern-receptors that detect invariant molecular signatures unique to pathogenic micro-organisms. Recognition of these signatures during acute infection triggers signaling cascades that enhance antimicrobial properties such as phagocytosis, secretion of pro-inflammatory cytokines and activation of the complement system. As well as coordinating the initial immune response, macrophages and dendritic cells present microbial antigens to lymphocytes, initiating and influencing the development of specific, long-lasting adaptive immunity. Despite extensive progress in unraveling the immunological adaptations of pregnancy, pregnant women remain particularly susceptible to certain acute viral infections and continue to experience mortality rates equivalent to those observed in pandemics several decades ago. Here, we focus specifically on the pregnancy-induced vulnerabilities in innate immunity that contribute to the disproportionately high maternal mortality observed in the following acute viral infections: Lassa fever, Ebola virus disease (EVD), dengue fever, hepatitis E, influenza, and novel coronavirus infections.", "doi": "10.3389/fimmu.2020.572567", "pmid": "33101294", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7556209"}], "notes": [], "created": "2020-11-26T12:26:42.810Z", "modified": "2020-11-27T11:47:54.134Z"}, {"entity": "publication", "iuid": "7349e144370e444abab068898e378e7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7349e144370e444abab068898e378e7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7349e144370e444abab068898e378e7e"}}, "title": "Impact of Coronavirus Disease 2019 (COVID-19) Outbreak on Acute Admissions at the Emergency and Cardiology Departments Across Europe.", "authors": [{"family": "Sokolski", "given": "Mateusz", "initials": "M"}, {"family": "Gajewski", "given": "Piotr", "initials": "P"}, {"family": "Zymli\u0144ski", "given": "Robert", "initials": "R"}, {"family": "Biegus", "given": "Jan", "initials": "J"}, {"family": "Berg", "given": "Jurrien M Ten", "initials": "JMT"}, {"family": "Bor", "given": "Wilbert", "initials": "W"}, {"family": "Braunschweig", "given": "Frieder", "initials": "F"}, {"family": "Caldeira", "given": "Daniel", "initials": "D"}, {"family": "Cuculi", "given": "Florim", "initials": "F"}, {"family": "D'Elia", "given": "Emilia", "initials": "E"}, {"family": "Edes", "given": "Istvan Ferenc", "initials": "IF"}, {"family": "Garus", "given": "Mateusz", "initials": "M"}, {"family": "Greenwood", "given": "John P", "initials": "JP"}, {"family": "Halfwerk", "given": "Frank R", "initials": "FR"}, {"family": "Hindricks", "given": "Gerhard", "initials": "G"}, {"family": "Knuuti", "given": "Juhani", "initials": "J"}, {"family": "Kristensen", "given": "Steen Dalby", "initials": "SD"}, {"family": "Landmesser", "given": "Ulf", "initials": "U"}, {"family": "Lund", "given": "Lars H", "initials": "LH"}, {"family": "Lyon", "given": "Alexander", "initials": "A"}, {"family": "Mebazaa", "given": "Alexandre", "initials": "A"}, {"family": "Merkely", "given": "B\u00e9la", "initials": "B"}, {"family": "Nawrocka-Millward", "given": "Sylwia", "initials": "S"}, {"family": "Pinto", "given": "Fausto J", "initials": "FJ"}, {"family": "Ruschitzka", "given": "Frank", "initials": "F"}, {"family": "Semedo", "given": "Edimir", "initials": "E"}, {"family": "Senni", "given": "Michele", "initials": "M"}, {"family": "Sepehri Shamloo", "given": "Alireza", "initials": "A"}, {"family": "Sorensen", "given": "Jacob", "initials": "J"}, {"family": "Stengaard", "given": "Carsten", "initials": "C"}, {"family": "Thiele", "given": "Holger", "initials": "H"}, {"family": "Toggweiler", "given": "Stefan", "initials": "S"}, {"family": "Tukiendorf", "given": "Andrzej", "initials": "A"}, {"family": "Verhorst", "given": "Patrick M", "initials": "PM"}, {"family": "Wright", "given": "David Jay", "initials": "DJ"}, {"family": "Zamorano", "given": "Pepe", "initials": "P"}, {"family": "Zuber", "given": "Michel", "initials": "M"}, {"family": "Narula", "given": "Jagat", "initials": "J"}, {"family": "Bax", "given": "Jeroen J", "initials": "JJ"}, {"family": "Ponikowski", "given": "Piotr", "initials": "P"}], "type": "journal article", "published": "2020-09-30", "journal": {"title": "Am J Med", "issn": "1555-7162", "volume": null, "issue": null, "issn-l": null}, "abstract": "We evaluated whether the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) pandemic was associated with changes in the pattern of acute cardiovascular admissions across European centers.\n\nWe set-up a multicenter, multinational, pan-European observational registry in 15 centers from 12 countries. All consecutive acute admissions to emergency departments and cardiology departments throughout a 1-month period during the COVID-19 outbreak were compared with an equivalent 1-month period in 2019. The acute admissions to cardiology departments were classified into 5 major categories: acute coronary syndrome, acute heart failure, arrhythmia, pulmonary embolism, and other.\n\nData from 54,331 patients were collected and analyzed. Nine centers provided data on acute admissions to emergency departments comprising 50,384 patients: 20,226 in 2020 compared with 30,158 in 2019 (incidence rate ratio [IRR] with 95% confidence interval [95%CI]: 0.66 [0.58-0.76]). The risk of death at the emergency departments was higher in 2020 compared to 2019 (odds ratio [OR] with 95% CI: 4.1 [3.0-5.8], P < 0.0001). All 15 centers provided data on acute cardiology departments admissions: 3007 patients in 2020 and 4452 in 2019; IRR (95% CI): 0.68 (0.64-0.71). In 2020, there were fewer admissions with IRR (95% CI): acute coronary syndrome: 0.68 (0.63-0.73); acute heart failure: 0.65 (0.58-0.74); arrhythmia: 0.66 (0.60-0.72); and other: 0.68(0.62-0.76). We found a relatively higher percentage of pulmonary embolism admissions in 2020: odds ratio (95% CI): 1.5 (1.1-2.1), P = 0.02. Among patients with acute coronary syndrome, there were fewer admissions with unstable angina: 0.79 (0.66-0.94); non-ST segment elevation myocardial infarction: 0.56 (0.50-0.64); and ST-segment elevation myocardial infarction: 0.78 (0.68-0.89).\n\nIn the European centers during the COVID-19 outbreak, there were fewer acute cardiovascular admissions. Also, fewer patients were admitted to the emergency departments with 4 times higher death risk at the emergency departments.", "doi": "10.1016/j.amjmed.2020.08.043", "pmid": "33010226", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0002-9343(20)30825-1"}, {"db": "pmc", "key": "PMC7526639"}], "notes": [], "created": "2020-12-03T08:54:27.721Z", "modified": "2021-02-26T08:46:13.256Z"}, {"entity": "publication", "iuid": "55408eb290b74ff58a7e7ce77a376726", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/55408eb290b74ff58a7e7ce77a376726.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/55408eb290b74ff58a7e7ce77a376726"}}, "title": "Transitioning Between Online Gambling Modalities and Decrease in Total Gambling Activity, but No Indication of Increase in Problematic Online Gambling Intensity During the First Phase of the COVID-19 Outbreak in Sweden: A Time Series Forecast Study.", "authors": [{"family": "Lindner", "given": "Philip", "initials": "P"}, {"family": "Forsstr\u00f6m", "given": "David", "initials": "D"}, {"family": "Jonsson", "given": "Jakob", "initials": "J"}, {"family": "Berman", "given": "Anne H", "initials": "AH"}, {"family": "Carlbring", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2020-09-29", "journal": {"title": "Front Public Health", "issn": "2296-2565", "issn-l": "2296-2565", "volume": "8", "issue": null, "pages": "554542"}, "abstract": "Introduction: The COVID-19 outbreak will likely have a public health impact beyond immediate disease transmission. Little is known about whether social distancing and other societal changes has provoked an increase in gambling, whether decreased betting opportunities due to paused sports events spurred gamblers to transition to online casino gambling, or whether any of these factors have had an impact on problem gambling. Methods: Data on lookup queries against the Swedish Gambling Paus registry, logging all initiated gambling sessions by all licensed gambling providers, from 2019-01-01 (start of registry) to 2020-04-08 (well into the first phase of the outbreak) were analyzed using TBATS time series forecasting to estimate trends after the first domestic COVID-19 death. Obfuscated data on daily total wagered and deposited amounts, split by modality (casino or betting, and low and high intensity, respectively) for the equivalent period were supplied by a licensed online gambling provider. Results: Total gambling activity decreased by 13.29% during the first phase of the outbreak compared to forecast. Analyses of online gambling data revealed that although betting decreased substantially in synchrony with a slight increase in online casino gambling, there was no increase in likely problematic, high-intensity gambling and neither did total online gambling increase. Conclusions: This first, preliminary study revealed no increase in Swedish gambling activity, total or specifically online, in the first phase of the COVID-19 outbreak. Future research should examine whether pandemic-induced transitioning between gambling modalities and/or increased participation in gambling, leads to long-term effects on prevalence of problem gambling.", "doi": "10.3389/fpubh.2020.554542", "pmid": "33117770", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7550730"}], "notes": [], "created": "2020-12-01T15:10:25.688Z", "modified": "2023-06-19T14:25:31.050Z"}, {"entity": "publication", "iuid": "252e6e3b499a4f00b054837e86a9f448", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/252e6e3b499a4f00b054837e86a9f448.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/252e6e3b499a4f00b054837e86a9f448"}}, "title": "Presence of SARS-CoV-2 in urine is rare and not associated with acute kidney injury in critically ill COVID-19 patients.", "authors": [{"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ceb4e6a253654e8e9b933916f4008c01.json"}}, {"family": "Bergqvist", "given": "Anders", "initials": "A"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}, {"family": "Lipcsey", "given": "Miklos", "initials": "M"}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2020-09-29", "journal": {"title": "Crit Care", "issn": "1466-609X", "issn-l": "1364-8535", "volume": "24", "issue": "1", "pages": "587"}, "abstract": null, "doi": "10.1186/s13054-020-03302-w", "pmid": "32993742", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-020-03302-w"}, {"db": "pmc", "key": "PMC7523248"}], "notes": [], "created": "2020-10-30T11:37:02.479Z", "modified": "2022-02-14T07:31:25.838Z"}, {"entity": "publication", "iuid": "4eb9d1599aef4d0d8d35c472a8e20ea9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4eb9d1599aef4d0d8d35c472a8e20ea9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4eb9d1599aef4d0d8d35c472a8e20ea9"}}, "title": "A common model for the breathlessness experience", "authors": [{"family": "Finnegan", "given": "Sarah L", "initials": "SL"}, {"family": "Pattinson", "given": "Kyle T S", "initials": "KTS"}, {"family": "Sundh", "given": "Josefin", "initials": "J"}, {"family": "Sk\u00f6ld", "given": "Magnus", "initials": "M"}, {"family": "Janson", "given": "Christer", "initials": "C"}, {"family": "Blomberg", "given": "Anders", "initials": "A"}, {"family": "Sandberg", "given": "Jacob", "initials": "J"}, {"family": "Ekstr\u00f6m", "given": "Magnus", "initials": "M"}], "type": "posted-content", "published": "2020-09-29", "journal": {"title": "", "issn": null, "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1101/2020.09.29.20203943", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-10T04:31:13.835Z", "modified": "2021-06-10T04:31:13.835Z"}, {"entity": "publication", "iuid": "5ed913f6997047d098f6186a54cff8bb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5ed913f6997047d098f6186a54cff8bb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5ed913f6997047d098f6186a54cff8bb"}}, "title": "MAIT cell activation and dynamics associated with COVID-19 disease severity.", "authors": [{"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Gorin", "given": "Jean-Baptiste", "initials": "J"}, {"family": "Ponzetta", "given": "Andrea", "initials": "A"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Kammann", "given": "Tobias", "initials": "T"}, {"family": "Emg\u00e5rd", "given": "Johanna", "initials": "J"}, {"family": "Perez-Potti", "given": "Andr\u00e9", "initials": "A"}, {"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Karolinska COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Folkesson", "given": "Elin", "initials": "E"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}], "type": "journal article", "published": "2020-09-28", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "issn-l": "2470-9468", "volume": "5", "issue": "51", "pages": null}, "abstract": "Severe COVID-19 is characterized by excessive inflammation of the lower airways. The balance of protective versus pathological immune responses in COVID-19 is incompletely understood. Mucosa-associated invariant T (MAIT) cells are antimicrobial T cells that recognize bacterial metabolites, and can also function as innate-like sensors and mediators of antiviral responses. Here, we investigated the MAIT cell compartment in COVID-19 patients with moderate and severe disease, as well as in convalescence. We show profound and preferential decline in MAIT cells in the circulation of patients with active disease paired with strong activation. Furthermore, transcriptomic analyses indicated significant MAIT cell enrichment and pro-inflammatory IL-17A bias in the airways. Unsupervised analysis identified MAIT cell CD69 high and CXCR3low immunotypes associated with poor clinical outcome. MAIT cell levels normalized in the convalescent phase, consistent with dynamic recruitment to the tissues and later release back into the circulation when disease is resolved. These findings indicate that MAIT cells are engaged in the immune response against SARS-CoV-2 and suggest their possible involvement in COVID-19 immunopathogenesis.", "doi": "10.1126/sciimmunol.abe1670", "pmid": "32989174", "labels": {"Type: Journal article": null, "Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Genomics & transcriptomics": null, "Category: Health": null, "Category: Proteins": null, "Funder: KAW/SciLifeLab": null}, "xrefs": [{"db": "URL", "key": "https://covid19cellatlas.com/#/", "description": "Curated flow cytometry data are available for exploration via the Karolinska COVID-19 Immune Atlas"}, {"db": "URL", "key": "https://www.science.org/doi/10.1126/sciimmunol.abe1670#", "description": "Raw data available in the supplementary materials"}], "notes": [], "created": "2020-10-28T09:05:35.876Z", "modified": "2021-11-18T08:57:57.308Z"}, {"entity": "publication", "iuid": "308f9d1f08cb40baba508a70b7f74083", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/308f9d1f08cb40baba508a70b7f74083.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/308f9d1f08cb40baba508a70b7f74083"}}, "title": "Characteristics and short-term obstetric outcomes in a case series of 67 women test-positive for SARS-CoV-2 in Stockholm, Sweden.", "authors": [{"family": "Remaeus", "given": "Katarina", "initials": "K"}, {"family": "Savchenko", "given": "Julia", "initials": "J"}, {"family": "Brismar Wendel", "given": "Sophia", "initials": "S"}, {"family": "Brusell Gidl\u00f6f", "given": "Sebastian", "initials": "S"}, {"family": "Graner", "given": "Sophie", "initials": "S"}, {"family": "Jones", "given": "Elin", "initials": "E"}, {"family": "Molin", "given": "Johanna", "initials": "J"}, {"family": "Saltvedt", "given": "Sissel", "initials": "S"}, {"family": "Wallstr\u00f6m", "given": "Tove", "initials": "T"}, {"family": "Pettersson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2020-09-27", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "12", "pages": "1626-1631", "issn-l": "0001-6349"}, "abstract": "The Stockholm region was the first area in Sweden to be hit by the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The national guidelines on the care of women with a positive test for SARS-CoV-2 (detection with polymerase chain reaction [PCR]) recommend individualized antenatal care, mode of delivery based on obstetric considerations, and no routine separation of the mother and the newborn. Breastfeeding is encouraged, and although there is no specific recommendation regarding wearing a face mask to prevent viral transmission to the newborn while nursing, instructions are given to keep high hygiene standards. All studies based on cases tested on hospital admission will capture more women with pregnancy complications than in the general population. Our aim was to describe the clinical characteristics of SARS-CoV-2-positive women and their neonates, and to report short-term maternal and neonatal outcomes.\n\nA retrospective case series with data from medical records including all test-positive women (n = 67) who gave birth to 68 neonates from 19 March to 26 April 2020 in Stockholm, Sweden. Means, proportions and percentages were calculated for clinical characteristics and outcomes.\n\nThe mean age was 32 years, 40% were nulliparous and 61% were overweight or obese. Further, 15% had diabetes and 21% a hypertensive disease. Seventy percent of the women had a vaginal birth. Preterm delivery occurred in 19% of the women. The preterm deliveries were mostly medically indicated, including two women who were delivered preterm due to severe coronavirus disease 19 (COVID-19), corresponding to 15% of the preterm births. Four women (6%) were admitted to the intensive care unit postpartum but there were no maternal deaths. There were two perinatal deaths (one stillbirth and one neonatal death). Three neonates were PCR-positive for SARS-CoV-2 after birth.\n\nIn this case series of 67 women testing positive for SARS-CoV-2 with clinical presentations ranging from asymptomatic to manifest COVID-19 disease, few women presented with severe COVID-19 illness. The majority had a vaginal birth at term with a healthy neonate that was negative for SARS-CoV-2.", "doi": "10.1111/aogs.14006", "pmid": "32981033", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7537005"}], "notes": [], "created": "2020-11-18T17:02:04.781Z", "modified": "2021-02-26T08:45:48.016Z"}, {"entity": "publication", "iuid": "9175d3585166411d81c584242c79bed8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9175d3585166411d81c584242c79bed8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9175d3585166411d81c584242c79bed8"}}, "title": "Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation.", "authors": [{"family": "Wallentin", "given": "Lars", "initials": "L"}, {"family": "Lindb\u00e4ck", "given": "Johan", "initials": "J"}, {"family": "Eriksson", "given": "Niclas", "initials": "N"}, {"family": "Hijazi", "given": "Ziad", "initials": "Z"}, {"family": "Eikelboom", "given": "John W", "initials": "JW"}, {"family": "Ezekowitz", "given": "Michael D", "initials": "MD"}, {"family": "Granger", "given": "Christopher B", "initials": "CB"}, {"family": "Lopes", "given": "Renato D", "initials": "RD"}, {"family": "Yusuf", "given": "Salim", "initials": "S"}, {"family": "Oldgren", "given": "Jonas", "initials": "J"}, {"family": "Siegbahn", "given": "Agneta", "initials": "A"}], "type": "journal article", "published": "2020-09-27", "journal": {"title": "Eur Heart J", "issn": "1522-9645", "volume": "41", "issue": "41", "pages": "4037-4046", "issn-l": "0195-668X"}, "abstract": "The global COVID-19 pandemic is caused by the SARS-CoV-2 virus entering human cells using angiotensin-converting enzyme 2 (ACE2) as a cell surface receptor. ACE2 is shed to the circulation, and a higher plasma level of soluble ACE2 (sACE2) might reflect a higher cellular expression of ACE2. The present study explored the associations between sACE2 and clinical factors, cardiovascular biomarkers, and genetic variability.\r\n\r\nPlasma and DNA samples were obtained from two international cohorts of elderly patients with atrial fibrillation (n = 3999 and n = 1088). The sACE2 protein level was measured by the Olink Proteomics\u00ae Multiplex CVD II96 \u00d7 96 panel. Levels of the biomarkers high-sensitive cardiac troponin T (hs-cTnT), N-terminal probrain natriuretic peptide (NT-proBNP), growth differentiation factor 15 (GDF-15), C-reactive protein, interleukin-6, D-dimer, and cystatin-C were determined by immunoassays. Genome-wide association studies were performed by Illumina chips. Higher levels of sACE2 were statistically significantly associated with male sex, cardiovascular disease, diabetes, and older age. The sACE2 level was most strongly associated with the levels of GDF-15, NT-proBNP, and hs-cTnT. When adjusting for these biomarkers, only male sex remained associated with sACE2. We found no statistically significant genetic regulation of the sACE2 level.\r\n\r\nMale sex and clinical or biomarker indicators of biological ageing, cardiovascular disease, and diabetes are associated with higher sACE2 levels. The levels of GDF-15 and NT-proBNP, which are associated both with the sACE2 level and a higher risk for mortality and cardiovascular disease, might contribute to better identification of risk for severe COVID-19 infection.", "doi": "10.1093/eurheartj/ehaa697", "pmid": "32984892", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "5912214"}, {"db": "pmc", "key": "PMC7543499"}], "notes": [], "created": "2020-11-17T18:09:17.932Z", "modified": "2021-02-26T08:45:48.463Z"}, {"entity": "publication", "iuid": "eb89850b924e4388a4b97ddead5e4fde", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb89850b924e4388a4b97ddead5e4fde.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb89850b924e4388a4b97ddead5e4fde"}}, "title": "Sex Differences in Reported Adverse Drug Reactions to COVID-19 Drugs in a Global Database of Individual Case Safety Reports.", "authors": [{"family": "Zekarias", "given": "Alem", "initials": "A"}, {"family": "Watson", "given": "Sarah", "initials": "S"}, {"family": "Vidlin", "given": "Sara Hedfors", "initials": "SH"}, {"family": "Grundmark", "given": "Birgitta", "initials": "B"}], "type": "journal article", "published": "2020-09-25", "journal": {"title": "Drug Saf", "issn": "1179-1942", "volume": "43", "issue": "12", "pages": "1309-1314", "issn-l": "0114-5916"}, "abstract": "In late 2019, a new coronavirus-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-was discovered in Wuhan, China, and the World Health Organization later declared coronavirus disease 2019 (COVID-19) a pandemic. Numerous drugs have been repurposed and investigated for therapeutic effectiveness in the disease, including those from \"Solidarity,\" an international clinical trial (azithromycin, chloroquine, hydroxychloroquine, the fixed combination lopinavir/ritonavir, and remdesivir).\n\nOur objective was to evaluate adverse drug reaction (ADR) reporting for drugs when used in the treatment of COVID-19 compared with use for other indications, specifically focussing on sex differences.\n\nWe extracted reports on COVID-19-specific treatments from the global ADR database, VigiBase, using an algorithm developed to identify reports that listed COVID-19 as the indication. The Solidarity trial drugs were included, as were any drugs reported \u2265 100 times. We performed a descriptive comparison of reports for the same drugs used in non-COVID-19 indications. The data lock point date was 7 June 2020.\n\nIn total, 2573 reports were identified for drugs used in the treatment of COVID-19. In order of frequency, the most reported ADRs were electrocardiogram QT-prolonged, diarrhoea, nausea, hepatitis, and vomiting in males and diarrhoea, electrocardiogram QT-prolonged, nausea, vomiting, and upper abdominal pain in females. Other hepatic and kidney-related events were included in the top ten ADRs in males, whereas no hepatic or renal terms were reported for females. COVID-19-related reporting patterns differed from non-pandemic reporting for these drugs.\n\nReview of a global database of suspected ADR reports revealed sex differences in the reporting patterns for drugs used in the treatment of COVID-19. Patterns of ADR sex differences need further elucidation.", "doi": "10.1007/s40264-020-01000-8", "pmid": "32978702", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40264-020-01000-8"}, {"db": "pmc", "key": "PMC7518652"}], "notes": [], "created": "2020-11-22T09:50:11.774Z", "modified": "2020-11-27T12:40:03.156Z"}, {"entity": "publication", "iuid": "3ecce14ec16245e3bf05acf13930cd8c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3ecce14ec16245e3bf05acf13930cd8c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3ecce14ec16245e3bf05acf13930cd8c"}}, "title": "Public awareness, emotional reactions and human mobility in response to the COVID-19 outbreak in China - a population-based ecological study.", "authors": [{"family": "Li", "given": "Yuchen", "initials": "Y"}, {"family": "Zeng", "given": "Yu", "initials": "Y"}, {"family": "Liu", "given": "Guangdi", "initials": "G"}, {"family": "Lu", "given": "Donghao", "initials": "D"}, {"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Qiu", "given": "Jianqing", "initials": "J"}, {"family": "Zhang", "given": "Chao", "initials": "C"}, {"family": "Fall", "given": "Katja", "initials": "K"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Zhang", "given": "Wei", "initials": "W"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "journal article", "published": "2020-09-25", "journal": {"title": "Psychol Med", "issn": "1469-8978", "volume": null, "issue": null, "pages": "1-8", "issn-l": "0033-2917"}, "abstract": "The outbreak of COVID-19 generated severe emotional reactions, and restricted mobility was a crucial measure to reduce the spread of the virus. This study describes the changes in public emotional reactions and mobility patterns in the Chinese population during the COVID-19 outbreak.\n\nWe collected data on public emotional reactions in response to the outbreak through Weibo, the Chinese Twitter, between 1st January and 31st March 2020. Using anonymized location-tracking information, we analyzed the daily mobility patterns of approximately 90% of Sichuan residents.\n\nThere were three distinct phases of the emotional and behavioral reactions to the COVID-19 outbreak. The alarm phase (19th-26th January) was a restriction-free period, characterized by few new daily cases, but a large amount public negative emotions [the number of negative comments per Weibo post increased by 246.9 per day, 95% confidence interval (CI) 122.5-371.3], and a substantial increase in self-limiting mobility (from 45.6% to 54.5%, changing by 1.5% per day, 95% CI 0.7%-2.3%). The epidemic phase (27th January-15th February) exhibited rapidly increasing numbers of new daily cases, decreasing expression of negative emotions (a decrease of 27.3 negative comments per post per day, 95% CI -40.4 to -14.2), and a stabilized level of self-limiting mobility. The relief phase (16th February-31st March) had a steady decline in new daily cases and decreasing levels of negative emotion and self-limiting mobility.\n\nDuring the COVID-19 outbreak in China, the public's emotional reaction was strongest before the actual peak of the outbreak and declined thereafter. The change in human mobility patterns occurred before the implementation of restriction orders, suggesting a possible link between emotion and behavior.", "doi": "10.1017/S003329172000375X", "pmid": "32972473", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S003329172000375X"}, {"db": "pmc", "key": "PMC7542325"}], "notes": [], "created": "2020-12-03T15:07:39.951Z", "modified": "2021-02-26T08:45:48.088Z"}, {"entity": "publication", "iuid": "43f6cc5c2db44f8d9539cdc08d15ddee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/43f6cc5c2db44f8d9539cdc08d15ddee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/43f6cc5c2db44f8d9539cdc08d15ddee"}}, "title": "Presence of hyaluronan in lung alveoli in severe Covid-19 - an opening for new treatment options?", "authors": [{"family": "Hellman", "given": "Urban", "initials": "U"}, {"family": "Karlsson", "given": "Mats G", "initials": "MG"}, {"family": "Engstr\u00f6m-Laurent", "given": "Anna", "initials": "A"}, {"family": "Cajander", "given": "Sara", "initials": "S"}, {"family": "Dorofte", "given": "Luiza", "initials": "L"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Laurent", "given": "Claude", "initials": "C"}, {"family": "Blomberg", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-09-25", "journal": {"title": "J Biol Chem", "issn": "1083-351X", "volume": "295", "issue": "45", "pages": "15418-15422", "issn-l": "0021-9258"}, "abstract": "Severe corona virus disease 2019 (Covid-19) is characterized by inflammation of the lungs with increasing respiratory impairment. In fatal Covid-19, lungs at autopsy have been filled with a clear liquid jelly. However, the nature of this finding has not yet been determined.The aim of the study was to demonstrate if the lungs of fatal Covid-19 contain hyaluronan as it is associated with inflammation and acute respiratory distress syndrome (ARDS) and may have the appearance of liquid jelly.Lung tissue obtained at autopsy from three deceased Covid-19 patients was processed for hyaluronan histochemistry using a direct staining method and compared with staining in normal lung tissue.Stainings confirmed that hyaluronan is obstructing alveoli with presence in exudate and plugs, as well as in thickened perialveolar interstitium. In contrast, normal lungs only showed hyaluronan in intact alveolar walls and perivascular tissue. This is the first study to confirm prominent hyaluronan exudates in the alveolar spaces of Covid-19 lungs, supporting the notion that the macromolecule is involved in ARDS caused by SARS-CoV-2. The present finding may open up for new treatment options in severe Covid-19, aiming at reducing the presence and production of hyaluronan in the lungs.", "doi": "10.1074/jbc.AC120.015967", "pmid": "32978255", "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Imaging": null}, "xrefs": [{"db": "NA", "key": "Provided in the article: color light micrographs of autopsy lung tissue from the three Covid-19 cases", "description": null}], "notes": [], "created": "2020-10-28T09:07:27.329Z", "modified": "2021-02-26T08:45:36.597Z"}, {"entity": "publication", "iuid": "a61e49761bfe4a18b81bb94f09c05300", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a61e49761bfe4a18b81bb94f09c05300.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a61e49761bfe4a18b81bb94f09c05300"}}, "title": "Inactivation of SARS-CoV-2 and HCoV-229E in vitro by ColdZyme\u00ae a medical device mouth spray against the common cold.", "authors": [{"family": "Gudmundsdottir", "given": "\u00c1g\u00fasta", "initials": "\u00c1"}, {"family": "Scheving", "given": "Reynir", "initials": "R"}, {"family": "Lindberg", "given": "Fredrik", "initials": "F"}, {"family": "Stefansson", "given": "Bjarki", "initials": "B"}], "type": "journal article", "published": "2020-09-25", "journal": {"title": "J Med Virol", "issn": "1096-9071", "volume": null, "issue": null, "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic calls for effective and safe treatments. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 actively replicates in the throat, unlike SARS-CoV, and shows high pharyngeal viral shedding even in patients with mild symptoms of the disease. HCoV-229E is one of four coronaviruses causing the common cold. In this study, the efficacy of ColdZyme\u00ae (CZ-MD), a medical device mouth spray, was tested against SARS-CoV-2 and HCoV-229E in vitro. The CZ-MD provides a protective glycerol barrier containing cod trypsin as an ancillary component. Combined, these ingredients can inactivate common cold viruses in the throat and mouth. The CZ-MD is believed to act on the viral surface proteins that would perturb their entry pathway into cells. The efficacy and safety of the CZ-MD have been demonstrated in clinical trials on the common cold.\n\nThe ability of the CZ-MD to inactivate SARS-CoV-2 and HCoV-229E was tested using an in vitro virucidal suspension test (ASTM E1052).\n\nCZ-MD inactivated SARS-CoV-2 by 98.3% and HCoV-229E by 99.9%.\n\nCZ-MD mouth spray can inactivate the respiratory coronaviruses SARS-CoV-2 and HCoV-229E in vitro. Although the in vitro results presented cannot be directly translated into clinical efficacy, the study indicates that CZ-MD might offer a protective barrier against SARS-CoV-2 and a decreased risk of COVID-19 transmission.", "doi": "10.1002/jmv.26554", "pmid": "32975843", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7537187"}], "notes": [], "created": "2020-12-03T09:53:18.160Z", "modified": "2021-02-26T08:46:13.408Z"}, {"entity": "publication", "iuid": "f07eeb1d98f44403815c952ee55045c3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f07eeb1d98f44403815c952ee55045c3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f07eeb1d98f44403815c952ee55045c3"}}, "title": "Impact of COVID-19 on Online Gambling - A General Population Survey During the Pandemic.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-09-25", "journal": {"title": "Front Psychol", "issn": "1664-1078", "issn-l": "1664-1078", "volume": "11", "issue": null, "pages": "568543"}, "abstract": "The COVID-19 pandemic may have severe impact on mental health, and concerns have been raised about potentially increased online behavior and possibly increased gambling problems, such as in sports bettors at risk of transfer to even riskier forms of gambling during sports lock-down. Given the need for objective data about gambling behavior during the pandemic, the present analysis, from a project assessing online gambling in Sweden, aimed to study past-30-day gambling patterns in online gamblers in Sweden. The study, carried out in May, 2020, during the pandemic and its restrictions on society, included past-year online gamblers ( N = 997). Past-30-day gambling for several gambling types was lower compared to a previous study in online gamblers in the same setting, while online non-sports gambling remained at high levels. Those reporting sports betting even during a period with decreased sports betting occasions proved to have markedly higher gambling problems. COVID-19 may alter gambling behaviors, and online gamblers who maintain or initiate gambling types theoretically reduced by the crisis may represent a group at particular risk.", "doi": "10.3389/fpsyg.2020.568543", "pmid": "33101137", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7546777"}], "notes": [], "created": "2020-12-01T15:26:58.330Z", "modified": "2022-11-10T06:23:11.417Z"}, {"entity": "publication", "iuid": "02f623854eac45c9a12385a468181dfb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02f623854eac45c9a12385a468181dfb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02f623854eac45c9a12385a468181dfb"}}, "title": "Using volunteered geographic information to assess mobility in the early phases of the COVID-19 pandemic: a cross-city time series analysis of 41 cities in 22 countries from March 2nd to 26th 2020.", "authors": [{"family": "Vannoni", "given": "Matia", "initials": "M"}, {"family": "McKee", "given": "Martin", "initials": "M"}, {"family": "Semenza", "given": "Jan C", "initials": "JC"}, {"family": "Bonell", "given": "Chris", "initials": "C"}, {"family": "Stuckler", "given": "David", "initials": "D"}], "type": "journal article", "published": "2020-09-23", "journal": {"title": "Global Health", "issn": "1744-8603", "issn-l": "1744-8603", "volume": "16", "issue": "1", "pages": "85"}, "abstract": "Restricting mobility is a central aim for lowering contact rates and preventing COVID-19 transmission. Yet the impact on mobility of different non-pharmaceutical countermeasures in the earlier stages of the pandemic is not well-understood.\r\n\r\nTrends were evaluated using Citymapper's mobility index covering 2nd to 26th March 2020, expressed as percentages of typical usage periods from 0% as the lowest and 100% as normal. China and India were not covered. Multivariate fixed effects models were used to estimate the association of policies restricting movement on mobility before and after their introduction. Policy restrictions were assessed using the Oxford COVID-19 Government Response Stringency Index as well as measures coding the timing and degree of school and workplace closures, transport restrictions, and cancellation of mass gatherings.\r\n\r\n41 cities worldwide.\r\n\r\nCitymapper's mobility index.\r\n\r\nMobility declined in all major cities throughout March. Larger declines were seen in European than Asian cities. The COVID-19 Government Response Stringency Index was strongly associated with declines in mobility (r = - 0.75, p < 0.001). After adjusting for time-trends, we observed that implementing non-pharmaceutical countermeasures was associated with a decline of mobility of 10.0% for school closures (95% CI: 4.36 to 15.7%), 15.0% for workplace closures (95% CI: 10.2 to 19.8%), 7.09% for cancelling public events (95% CI: 1.98 to 12.2%), 18.0% for closing public transport (95% CI: 6.74 to 29.2%), 13.3% for restricting internal movements (95% CI: 8.85 to 17.8%) and 5.30% for international travel controls (95% CI: 1.69 to 8.90). In contrast, as expected, there was no association between population mobility changes and fiscal or monetary measures or emergency healthcare investment.\r\n\r\nUnderstanding the effect of public policy on mobility in the early stages is crucial to slowing and reducing COVID-19 transmission. By using Citymapper's mobility index, this work provides the first evidence about trends in mobility and the impacts of different policy interventions, suggesting that closure of public transport, workplaces and schools are particularly impactful.", "doi": "10.1186/s12992-020-00598-9", "pmid": "32967691", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12992-020-00598-9"}, {"db": "pmc", "key": "PMC7509494"}], "notes": [], "created": "2020-12-03T15:10:35.960Z", "modified": "2022-11-10T06:24:31.850Z"}, {"entity": "publication", "iuid": "b5ca3e7c61b14b03b1d97ab34f663163", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5ca3e7c61b14b03b1d97ab34f663163.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5ca3e7c61b14b03b1d97ab34f663163"}}, "title": "Small droplet emission in exhaled breath during different breathing manoeuvres: Implications for clinical lung function testing during COVID-19.", "authors": [{"family": "Greening", "given": "Neil J", "initials": "NJ"}, {"family": "Larsson", "given": "Per", "initials": "P"}, {"family": "Ljungstr\u00f6m", "given": "Evert", "initials": "E"}, {"family": "Siddiqui", "given": "Salman", "initials": "S"}, {"family": "Olin", "given": "Anna-Carin", "initials": "AC"}], "type": "letter", "published": "2020-09-23", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": null, "issue": null, "issn-l": "0105-4538"}, "abstract": null, "doi": "10.1111/all.14596", "pmid": "32966612", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7537081"}], "notes": [], "created": "2020-12-03T09:05:39.572Z", "modified": "2020-12-03T09:05:39.584Z"}, {"entity": "publication", "iuid": "018d04d578e04e89989323730b746c3f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/018d04d578e04e89989323730b746c3f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/018d04d578e04e89989323730b746c3f"}}, "title": "Massive and rapid COVID-19 testing is feasible by extraction-free SARS-CoV-2 RT-PCR.", "authors": [{"family": "Smyrlaki", "given": "Ioanna", "initials": "I"}, {"family": "Ekman", "given": "Martin", "initials": "M"}, {"family": "Lentini", "given": "Antonio", "initials": "A", "orcid": "0000-0003-1239-5495", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8c1f3989ef84f6d9803fb30b3014dc4.json"}}, {"family": "Rufino de Sousa", "given": "Nuno", "initials": "N", "orcid": "0000-0002-0670-9788", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1cb037a9e7f44a489dd84d6f5ba513d7.json"}}, {"family": "Papanicolaou", "given": "Natali", "initials": "N"}, {"family": "Vondracek", "given": "Martin", "initials": "M"}, {"family": "Aarum", "given": "Johan", "initials": "J"}, {"family": "Safari", "given": "Hamzah", "initials": "H"}, {"family": "Muradrasoli", "given": "Shaman", "initials": "S"}, {"family": "Rothfuchs", "given": "Antonio Gigliotti", "initials": "AG", "orcid": "0000-0001-6001-7240", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00102c49ae2d41828272e850cd551c9f.json"}}, {"family": "Albert", "given": "Jan", "initials": "J", "orcid": "0000-0001-9020-0521", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/79a6c7eedadb4a1e8c6fd7b8b522a8e3.json"}}, {"family": "H\u00f6gberg", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0003-2715-7887", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11deae9980bd4bf6859b25de2b0c3908.json"}}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-7021-5248", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9eef54f4e0534805b173cfae62a75d55.json"}}], "type": "comparative study", "published": "2020-09-23", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "11", "issue": "1", "pages": "4812"}, "abstract": "Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is commonly diagnosed by reverse transcription polymerase chain reaction (RT-PCR) to detect viral RNA in patient samples, but RNA extraction constitutes a major bottleneck in current testing. Methodological simplification could increase diagnostic availability and efficiency, benefitting patient care and infection control. Here, we describe methods circumventing RNA extraction in COVID-19 testing by performing RT-PCR directly on heat-inactivated or lysed samples. Our data, including benchmarking using 597 clinical patient samples and a standardised diagnostic system, demonstrate that direct RT-PCR is viable option to extraction-based tests. Using controlled amounts of active SARS-CoV-2, we confirm effectiveness of heat inactivation by plaque assay and evaluate various generic buffers as transport medium for direct RT-PCR. Significant savings in time and cost are achieved through RNA-extraction-free protocols that are directly compatible with established PCR-based testing pipelines. This could aid expansion of COVID-19 testing.", "doi": "10.1038/s41467-020-18611-5", "pmid": "32968075", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Diagnostics for virus": null}, "xrefs": [{"db": "pmc", "key": "PMC7511968"}, {"db": "pii", "key": "10.1038/s41467-020-18611-5"}], "notes": [], "created": "2020-10-30T12:04:36.610Z", "modified": "2023-06-19T15:01:27.658Z"}, {"entity": "publication", "iuid": "c9df8b74343c4af8870f002b5a1f4c99", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9df8b74343c4af8870f002b5a1f4c99.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9df8b74343c4af8870f002b5a1f4c99"}}, "title": "Association of SARS-CoV-2 Test Status and Pregnancy Outcomes.", "authors": [{"family": "Ahlberg", "given": "Mia", "initials": "M"}, {"family": "Neovius", "given": "Martin", "initials": "M"}, {"family": "Saltvedt", "given": "Sissel", "initials": "S"}, {"family": "S\u00f6derling", "given": "Jonas", "initials": "J"}, {"family": "Pettersson", "given": "Karin", "initials": "K"}, {"family": "Brandkvist", "given": "Clara", "initials": "C"}, {"family": "Stephansson", "given": "Olof", "initials": "O"}], "type": "journal article", "published": "2020-09-23", "journal": {"title": "JAMA", "issn": "1538-3598", "issn-l": "0098-7484", "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1001/jama.2020.19124", "pmid": "32965467", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "2771110"}, {"db": "pmc", "key": "PMC7512127"}], "notes": [], "created": "2020-11-18T17:03:47.315Z", "modified": "2021-02-26T08:45:48.707Z"}, {"entity": "publication", "iuid": "209ab7dba5694ea6a03b0ca5ab24a397", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/209ab7dba5694ea6a03b0ca5ab24a397.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/209ab7dba5694ea6a03b0ca5ab24a397"}}, "title": "Psychosocial emergency care in times of COVID-19: the Essen University Hospital concept for corona-infected patients, their relatives, and medical staff.", "authors": [{"family": "Rentrop", "given": "Vanessa", "initials": "V"}, {"family": "Schneider", "given": "Johanna Sophie", "initials": "JS"}, {"family": "B\u00e4uerle", "given": "Alexander", "initials": "A"}, {"family": "Junne", "given": "Florian", "initials": "F"}, {"family": "D\u00f6rrie", "given": "Nora", "initials": "N"}, {"family": "Skoda", "given": "Eva-Maria", "initials": "E"}, {"family": "Schedlowski", "given": "Manfred", "initials": "M"}, {"family": "Mallmann", "given": "Bernhard", "initials": "B"}, {"family": "Benecke", "given": "Anke-Verena", "initials": "A"}, {"family": "Kohler", "given": "Hannah", "initials": "H"}, {"family": "Gerigk", "given": "Monja", "initials": "M"}, {"family": "Teigelack", "given": "Per", "initials": "P"}, {"family": "Emler", "given": "Tobias", "initials": "T"}, {"family": "Scherbaum", "given": "Norbert", "initials": "N"}, {"family": "Gradl-Dietsch", "given": "Gertraud", "initials": "G"}, {"family": "Scheer", "given": "Karin", "initials": "K"}, {"family": "Teufel", "given": "Martin", "initials": "M"}], "type": "letter", "published": "2020-09-22", "journal": {"title": "Int Arch Occup Environ Health", "issn": "1432-1246", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Due to the SARS CoV-2-virus (COVID-19), anxiety, distress, and insecurity occur more frequently. In particular, infected individuals, their relatives, and medical staff face an increased risk of high psychological distress as a result of the ongoing pandemic. Thus, structured psychosocial emergency concepts are needed. The University hospital of Essen has taken up this challenge by creating the PEC concept to reduce psychosocial long-term consequences for infected patients, relatives, and medical staff at the university hospital. The concept includes professional medical as well as psychological support to convey constructive coping strategies and the provision of adequate tools such as the low-threshold online training program (CoPE It), which is accessible via the webpage www.cope-corona.de .", "doi": "10.1007/s00420-020-01580-z", "pmid": "32964313", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00420-020-01580-z"}, {"db": "pmc", "key": "PMC7508238"}], "notes": [], "created": "2020-12-03T09:23:51.961Z", "modified": "2022-11-10T06:25:29.610Z"}, {"entity": "publication", "iuid": "94fad26a33554d9aa598c2b1d08311fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/94fad26a33554d9aa598c2b1d08311fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/94fad26a33554d9aa598c2b1d08311fd"}}, "title": "Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19.", "authors": [{"family": "Kanberg", "given": "Nelly", "initials": "N"}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ"}, {"family": "Andersson", "given": "Lars-Magnus", "initials": "LM"}, {"family": "Yilmaz", "given": "Aylin", "initials": "A"}, {"family": "Lindh", "given": "Magnus", "initials": "M"}, {"family": "Nilsson", "given": "Staffan", "initials": "S"}, {"family": "Price", "given": "Richard W", "initials": "RW"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2020-09-22", "journal": {"title": "Neurology", "issn": "1526-632X", "volume": "95", "issue": "12", "pages": "e1754-e1759", "issn-l": "0028-3878"}, "abstract": "To test the hypothesis that coronavirus disease 2019 (COVID-19) has an impact on the CNS by measuring plasma biomarkers of CNS injury.\n\nWe recruited 47 patients with mild (n = 20), moderate (n = 9), or severe (n = 18) COVID-19 and measured 2 plasma biomarkers of CNS injury by single molecule array, neurofilament light chain protein (NfL; a marker of intra-axonal neuronal injury) and glial fibrillary acidic protein (GFAp; a marker of astrocytic activation/injury), in samples collected at presentation and again in a subset after a mean of 11.4 days. Cross-sectional results were compared with results from 33 age-matched controls derived from an independent cohort.\n\nThe patients with severe COVID-19 had higher plasma concentrations of GFAp ( p = 0.001) and NfL (p < 0.001) than controls, while GFAp was also increased in patients with moderate disease (p = 0.03). In patients with severe disease, an early peak in plasma GFAp decreased on follow-up (p < 0.01), while NfL showed a sustained increase from first to last follow-up (p < 0.01), perhaps reflecting a sequence of early astrocytic response and more delayed axonal injury.\n\nWe show neurochemical evidence of neuronal injury and glial activation in patients with moderate and severe COVID-19. Further studies are needed to clarify the frequency and nature of COVID-19-related CNS damage and its relation to both clinically defined CNS events such as hypoxic and ischemic events and mechanisms more closely linked to systemic severe acute respiratory syndrome coronavirus 2 infection and consequent immune activation, as well as to evaluate the clinical utility of monitoring plasma NfL and GFAp in the management of this group of patients.", "doi": "10.1212/WNL.0000000000010111", "pmid": "32546655", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "NA", "key": "Researchers can apply for access to anonymized data", "description": null}], "notes": [], "created": "2020-10-30T11:38:14.005Z", "modified": "2021-02-26T08:45:03.162Z"}, {"entity": "publication", "iuid": "7853c20a2ac34fef9a21a1b25175065a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7853c20a2ac34fef9a21a1b25175065a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7853c20a2ac34fef9a21a1b25175065a"}}, "title": "Mitigation of the replication of SARS-CoV-2 by nitric oxide in vitro", "authors": [{"family": "Akaberi", "given": "Dario", "initials": "D"}, {"family": "Krambrich", "given": "Janina", "initials": "J"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Luni", "given": "Chen", "initials": "C"}, {"family": "Hedenstierna", "given": "G\u00f6ran", "initials": "G"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}, {"family": "Lennerstrand", "given": "Johan", "initials": "J"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "journal-article", "published": "2020-09-21", "journal": {"title": "Redox Biology", "issn": "2213-2317", "issn-l": "2213-2317", "volume": "37", "issue": null, "pages": "101734"}, "abstract": "The ongoing SARS-CoV-2 pandemic is a global public health emergency posing a high burden on nations' health care systems and economies. Despite the great effort put in the development of vaccines and specific treatments, no prophylaxis or effective therapeutics are currently available. Nitric oxide (NO) is a broad-spectrum antimicrobial and a potent vasodilator that has proved to be effective in reducing SARS-CoV replication and hypoxia in patients with severe acute respiratory syndrome. Given the potential of NO as treatment for SARS-CoV-2 infection, we have evaluated the in vitro antiviral effect of NO on SARS-CoV-2 replication. The NO-donor S-nitroso-N-acetylpenicillamine (SNAP) had a dose dependent inhibitory effect on SARS-CoV-2 replication, while the non S-nitrosated NAP was not active, as expected. Although the viral replication was not completely abolished (at 200 \u03bcM and 400 \u03bcM), SNAP delayed or completely prevented the development of viral cytopathic effect in treated cells, and the observed protective effect correlated with the level of inhibition of the viral replication. The capacity of the NO released from SNAP to covalently bind and inhibit SARS-CoV-2 3CL recombinant protease in vitro was also tested. The observed reduction in SARS-CoV-2 protease activity was consistent with S-nitrosation of the enzyme active site cysteine.", "doi": "10.1016/j.redox.2020.101734", "pmid": "33007504", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Drug discovery and repurposing of drugs": null, "Category: Imaging": null, "Category: Proteins": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.1016/j.redox.2020.101734", "description": "Supplementary data"}], "notes": [], "created": "2020-10-30T11:25:59.730Z", "modified": "2021-06-14T14:31:10.633Z"}, {"entity": "publication", "iuid": "755e672d6e4b461c92ec69293c239cf2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/755e672d6e4b461c92ec69293c239cf2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/755e672d6e4b461c92ec69293c239cf2"}}, "title": "Crisis Management by Journal Editors: Case of COVID-19.", "authors": [{"family": "Sorooshian", "given": "Shahryar", "initials": "S"}], "type": "journal article", "published": "2020-09-21", "journal": {"title": "J Korean Med Sci", "issn": "1598-6357", "volume": "35", "issue": "37", "pages": "e320", "issn-l": null}, "abstract": null, "doi": "10.3346/jkms.2020.35.e320", "pmid": "32959545", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "35.e320"}, {"db": "pmc", "key": "PMC7505727"}], "notes": [], "created": "2020-12-03T09:25:25.650Z", "modified": "2020-12-03T09:25:25.675Z"}, {"entity": "publication", "iuid": "b8e24bc4dbf245908a5bf678a0c3b0b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8e24bc4dbf245908a5bf678a0c3b0b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8e24bc4dbf245908a5bf678a0c3b0b9"}}, "title": "Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test.", "authors": [{"family": "De Marinis", "given": "Yang", "initials": "Y"}, {"family": "Sunnerhagen", "given": "Torgny", "initials": "T"}, {"family": "Bompada", "given": "Pradeep", "initials": "P"}, {"family": "Bl\u00e4ckberg", "given": "Anna", "initials": "A"}, {"family": "Yang", "given": "Runtao", "initials": "R"}, {"family": "Svensson", "given": "Joel", "initials": "J"}, {"family": "Ekstr\u00f6m", "given": "Ola", "initials": "O"}, {"family": "Eriksson", "given": "Karl-Fredrik", "initials": "K"}, {"family": "Hansson", "given": "Ola", "initials": "O"}, {"family": "Groop", "given": "Leif", "initials": "L"}, {"family": "Gon\u00e7alves", "given": "Isabel", "initials": "I"}, {"family": "Rasmussen", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2020-09-20", "journal": {"title": "Infect Ecol Epidemiol", "issn": "2000-8686", "issn-l": "2000-8686", "volume": "10", "issue": "1", "pages": "1821513"}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has created a global health- and economic crisis. Detection of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19 by serological methods is important to diagnose a current or resolved infection. In this study, we applied a rapid COVID-19 IgM/IgG antibody test and performed serology assessment of antibody response to SARS-CoV-2. In PCR-confirmed COVID-19 patients (n = 45), the total antibody detection rate is 92% in hospitalized patients and 79% in non-hospitalized patients. The total IgM and IgG detection is 63% in patients with <2 weeks from disease onset; 85% in non-hospitalized patients with >2 weeks disease duration; and 91% in hospitalized patients with >2 weeks disease duration. We also compared different blood sample types and suggest a higher sensitivity by serum/plasma over whole blood. Test specificity was determined to be 97% on 69 sera/plasma samples collected between 2016-2018. Our study provides a comprehensive validation of the rapid COVID-19 IgM/IgG serology test, and mapped antibody detection patterns in association with disease progress and hospitalization. Our results support that the rapid COVID-19 IgM/IgG test may be applied to assess the COVID-19 status both at the individual and at a population level.", "doi": "10.1080/20008686.2020.1821513", "pmid": "33062217", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Serology": null}, "xrefs": [{"db": "pii", "key": "1821513"}, {"db": "pmc", "key": "PMC7534290"}], "notes": [], "created": "2020-12-01T17:09:23.638Z", "modified": "2021-02-26T08:46:49.378Z"}, {"entity": "publication", "iuid": "b1f90548f04e4b07a655403478429adf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1f90548f04e4b07a655403478429adf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1f90548f04e4b07a655403478429adf"}}, "title": "COVID-19 healthcare demand and mortality in Sweden in response to non-pharmaceutical mitigation and suppression scenarios.", "authors": [{"family": "Sj\u00f6din", "given": "Henrik", "initials": "H"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}, {"family": "Br\u00e4nnstr\u00f6m", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Farooq", "given": "Zia", "initials": "Z"}, {"family": "Kriit", "given": "Hedi Katre", "initials": "HK"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "\u00c5str\u00f6m", "given": "Christofer", "initials": "C"}, {"family": "Thunberg", "given": "Johan", "initials": "J"}, {"family": "S\u00f6derquist", "given": "M\u00e5rten", "initials": "M"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}], "type": "journal article", "published": "2020-09-20", "journal": {"title": "Int J Epidemiol", "issn": "1464-3685", "issn-l": "0300-5771", "volume": "49", "issue": "5", "pages": "1443-1453"}, "abstract": "While the COVID-19 outbreak in China now appears suppressed, Europe and the USA have become the epicentres, both reporting many more deaths than China. Responding to the pandemic, Sweden has taken a different approach aiming to mitigate, not suppress, community transmission, by using physical distancing without lockdowns. Here we contrast the consequences of different responses to COVID-19 within Sweden, the resulting demand for care, intensive care, the death tolls and the associated direct healthcare related costs.\r\n\r\nWe used an age-stratified health-care demand extended SEIR (susceptible, exposed, infectious, recovered) compartmental model for all municipalities in Sweden, and a radiation model for describing inter-municipality mobility. The model was calibrated against data from municipalities in the Stockholm healthcare region.\r\n\r\nOur scenario with moderate to strong physical distancing describes well the observed health demand and deaths in Sweden up to the end of May 2020. In this scenario, the intensive care unit (ICU) demand reaches the pre-pandemic maximum capacity just above 500 beds. In the counterfactual scenario, the ICU demand is estimated to reach \u223c20 times higher than the pre-pandemic ICU capacity. The different scenarios show quite different death tolls up to 1 September, ranging from 5000 to 41 000, excluding deaths potentially caused by ICU shortage. Additionally, our statistical analysis of all causes excess mortality indicates that the number of deaths attributable to COVID-19 could be increased by 40% (95% confidence interval: 0.24, 0.57).\r\n\r\nThe results of this study highlight the impact of different combinations of non-pharmaceutical interventions, especially moderate physical distancing in combination with more effective isolation of infectious individuals, on reducing deaths, health demands and lowering healthcare costs. In less effective mitigation scenarios, the demand on ICU beds would rapidly exceed capacity, showing the tight interconnection between the healthcare demand and physical distancing in the society. These findings have relevance for Swedish policy and response to the COVID-19 pandemic and illustrate the importance of maintaining the level of physical distancing for a longer period beyond the study period to suppress or mitigate the impacts from the pandemic.", "doi": "10.1093/ije/dyaa121", "pmid": "32954400", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "5909271"}, {"db": "pmc", "key": "PMC7543571"}], "notes": [], "created": "2020-12-03T09:31:56.254Z", "modified": "2022-11-10T06:27:58.330Z"}, {"entity": "publication", "iuid": "865012848aa3469da99c9e119fb80623", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/865012848aa3469da99c9e119fb80623.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/865012848aa3469da99c9e119fb80623"}}, "title": "COVID Isolation Eating Scale (CIES): Analysis of the impact of confinement in eating disorders and obesity-A collaborative international study.", "authors": [{"family": "Fern\u00e1ndez-Aranda", "given": "Fernando", "initials": "F"}, {"family": "Mungu\u00eda", "given": "Lucero", "initials": "L"}, {"family": "Mestre-Bach", "given": "Gemma", "initials": "G"}, {"family": "Steward", "given": "Trevor", "initials": "T"}, {"family": "Etxandi", "given": "Mikel", "initials": "M"}, {"family": "Baenas", "given": "Isabel", "initials": "I"}, {"family": "Granero", "given": "Roser", "initials": "R"}, {"family": "S\u00e1nchez", "given": "Isabel", "initials": "I"}, {"family": "Ortega", "given": "Emilio", "initials": "E"}, {"family": "Andreu", "given": "Alba", "initials": "A"}, {"family": "Moize", "given": "Violeta L", "initials": "VL"}, {"family": "Fern\u00e1ndez-Real", "given": "Jose M", "initials": "JM"}, {"family": "Tinahones", "given": "Francisco J", "initials": "FJ"}, {"family": "Dieg\u00fcez", "given": "Carlos", "initials": "C"}, {"family": "Fr\u00fchbeck", "given": "Gema", "initials": "G"}, {"family": "Le Grange", "given": "Daniel", "initials": "D"}, {"family": "Tchanturia", "given": "Kate", "initials": "K"}, {"family": "Karwautz", "given": "Andreas", "initials": "A"}, {"family": "Zeiler", "given": "Michael", "initials": "M"}, {"family": "Favaro", "given": "Angela", "initials": "A"}, {"family": "Claes", "given": "Laurence", "initials": "L"}, {"family": "Luyckx", "given": "Koen", "initials": "K"}, {"family": "Shekriladze", "given": "Ia", "initials": "I"}, {"family": "Serrano-Troncoso", "given": "Eduardo", "initials": "E"}, {"family": "Rangil", "given": "Teresa", "initials": "T"}, {"family": "Meler", "given": "Maria Eulalia Loran", "initials": "MEL"}, {"family": "Soriano-Pacheco", "given": "Jose", "initials": "J"}, {"family": "Carceller-Sindreu", "given": "Mar", "initials": "M"}, {"family": "Bujalance-Arguijo", "given": "Sara", "initials": "S"}, {"family": "Lozano", "given": "Meritxell", "initials": "M"}, {"family": "Linares", "given": "Raquel", "initials": "R"}, {"family": "Gudiol", "given": "Carlota", "initials": "C"}, {"family": "Carratala", "given": "Jordi", "initials": "J"}, {"family": "Sanchez-Gonzalez", "given": "Jessica", "initials": "J"}, {"family": "Machado", "given": "Paulo Pp", "initials": "PP"}, {"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "T\u00fary", "given": "Ferenc", "initials": "F"}, {"family": "P\u00e1szthy", "given": "Bea", "initials": "B"}, {"family": "Stein", "given": "Daniel", "initials": "D"}, {"family": "Papezov\u00e1", "given": "Hana", "initials": "H"}, {"family": "Bax", "given": "Brigita", "initials": "B"}, {"family": "Borisenkov", "given": "Mikhail F", "initials": "MF"}, {"family": "Popov", "given": "Sergey V", "initials": "SV"}, {"family": "Kim", "given": "Youl-Ri", "initials": "YR"}, {"family": "Nakazato", "given": "Michiko", "initials": "M"}, {"family": "Godart", "given": "Nathalie", "initials": "N"}, {"family": "van Voren", "given": "Robert", "initials": "R"}, {"family": "Ilnytska", "given": "Tetiana", "initials": "T"}, {"family": "Chen", "given": "Jue", "initials": "J"}, {"family": "Rowlands", "given": "Katie", "initials": "K"}, {"family": "Treasure", "given": "Janet", "initials": "J"}, {"family": "Jim\u00e9nez-Murcia", "given": "Susana", "initials": "S"}], "type": "journal article", "published": "2020-09-20", "journal": {"title": "Eur Eat Disord Rev", "issn": "1099-0968", "volume": null, "issue": null, "issn-l": null}, "abstract": "Confinement during the COVID-19 pandemic is expected to have a serious and complex impact on the mental health of patients with an eating disorder (ED) and of patients with obesity. The present manuscript has the following aims: (1) to analyse the psychometric properties of the COVID Isolation Eating Scale (CIES), (2) to explore changes that occurred due to confinement in eating symptomatology; and (3) to explore the general acceptation of the use of telemedicine during confinement. The sample comprised 121 participants (87 ED patients and 34 patients with obesity) recruited from six different centres. Confirmatory Factor Analyses (CFA) tested the rational-theoretical structure of the CIES. Adequate goodness-of-fit was obtained for the confirmatory factor analysis, and Cronbach alpha values ranged from good to excellent. Regarding the effects of confinement, positive and negative impacts of the confinement depends of the eating disorder subtype. Patients with anorexia nervosa (AN) and with obesity endorsed a positive response to treatment during confinement, no significant changes were found in bulimia nervosa (BN) patients, whereas Other Specified Feeding or Eating Disorder (OSFED) patients endorsed an increase in eating symptomatology and in psychopathology. Furthermore, AN patients expressed the greatest dissatisfaction and accommodation difficulty with remote therapy when compared with the previously provided face-to-face therapy. The present study provides empirical evidence on the psychometric robustness of the CIES tool and shows that a negative confinement impact was associated with ED subtype, whereas OSFED patients showed the highest impairment in eating symptomatology and in psychopathology.", "doi": "10.1002/erv.2784", "pmid": "32954595", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7537123"}], "notes": [], "created": "2020-12-03T09:30:37.325Z", "modified": "2020-12-03T09:30:37.348Z"}, {"entity": "publication", "iuid": "dcbf0bc0b92644a78d80a9dc708e6f34", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dcbf0bc0b92644a78d80a9dc708e6f34.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dcbf0bc0b92644a78d80a9dc708e6f34"}}, "title": "Sex differences in severity and mortality from COVID-19: are males more vulnerable?", "authors": [{"family": "Pradhan", "given": "Ajay", "initials": "A"}, {"family": "Olsson", "given": "Per-Erik", "initials": "PE"}], "type": "journal article", "published": "2020-09-18", "journal": {"title": "Biol Sex Differ", "issn": "2042-6410", "volume": "11", "issue": "1", "pages": "53", "issn-l": "2042-6410"}, "abstract": "Coronavirus disease 2019 (COVID-19) has shown high infection and mortality rates all over the world, and despite the global efforts, there is so far no specific therapy available for COVID-19. Interestingly, while the severity and mortality of COVID-19 are higher in males than in females, the underlying molecular mechanisms are unclear. In this review, we explore sex-related differences that may be contributing factors to the observed male-biased mortality from COVID-19. Males are considered the weaker sex in aspects related to endurance and infection control. Studies show that viral RNA clearance is delayed in males with COVID-19. A recent study has indicated that the testis can harbor coronavirus, and consequently, males show delayed viral clearance. However, the role of testis involvement in COVID-19 severity and mortality needs further research. Males and females show a distinct difference in immune system responses with females eliciting stronger immune responses to pathogens. This difference in immune system responses may be a major contributing factor to viral load, disease severity, and mortality. In addition, differences in sex hormone milieus could also be a determinant of viral infections as estrogen has immunoenhancing effects while testosterone has immunosuppressive effects. The sex-specific severity of COVID-19 infections indicates that further research on understanding the sex differences is needed. Inclusion of both males and females in basic research and clinical trials is required to provide critical information on sex-related differences that may help to better understand disease outcome and therapy.", "doi": "10.1186/s13293-020-00330-7", "pmid": "32948238", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13293-020-00330-7"}, {"db": "pmc", "key": "PMC7498997"}], "notes": [], "created": "2020-11-27T12:42:10.704Z", "modified": "2020-12-03T15:25:40.954Z"}, {"entity": "publication", "iuid": "17096ef2059d48928978ad8b31f503c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/17096ef2059d48928978ad8b31f503c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/17096ef2059d48928978ad8b31f503c5"}}, "title": "Death associated with coronavirus (COVID-19) infection in individuals with severe mental disorders in Sweden during the early months of the outbreak \u2013 a exploratory cross-sectional analysis of a population-based register study", "authors": [{"family": "Maripuu", "given": "Martin", "initials": "M", "orcid": "0000-0001-7868-8894", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9f85873e152d421eba74e23054d0ff1e.json"}}, {"family": "Bendix", "given": "Marie", "initials": "M", "orcid": "0000-0001-8901-166X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/bbc1ba16f8c54e4e98e833c7066cf410.json"}}, {"family": "\u00d6hlund", "given": "Louise", "initials": "L", "orcid": "0000-0001-8271-5058", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0c5008f4a48142269efb983389b805d0.json"}}, {"family": "Widerstr\u00f6m", "given": "Micael", "initials": "M", "orcid": "0000-0002-1483-4255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ad36fa63a334e3b91499527bb6d5659.json"}}, {"family": "Werneke", "given": "Ursula", "initials": "U", "orcid": "0000-0002-5023-3254", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7eed3b002ddb4cbba141cbfdc8d3f032.json"}}], "type": "posted-content", "published": "2020-09-18", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.09.14.20193987", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-14T06:40:14.574Z", "modified": "2022-11-22T05:52:46.830Z"}, {"entity": "publication", "iuid": "18b57d426c8641fa8ffe2f8ea572a873", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18b57d426c8641fa8ffe2f8ea572a873.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18b57d426c8641fa8ffe2f8ea572a873"}}, "title": "Community knowledge, perceptions and practices around COVID-19 in Sierra Leone: a nationwide, cross-sectional survey.", "authors": [{"family": "Sengeh", "given": "Paul", "initials": "P"}, {"family": "Jalloh", "given": "Mohammad B", "initials": "MB"}, {"family": "Webber", "given": "Nance", "initials": "N"}, {"family": "Ngobeh", "given": "Ibrahim", "initials": "I"}, {"family": "Samba", "given": "Thomas", "initials": "T"}, {"family": "Thomas", "given": "Harold", "initials": "H"}, {"family": "Nordenstedt", "given": "Helena", "initials": "H"}, {"family": "Winters", "given": "Maike", "initials": "M"}], "type": "journal article", "published": "2020-09-17", "journal": {"title": "BMJ Open", "issn": "2044-6055", "issn-l": "2044-6055", "volume": "10", "issue": "9", "pages": "e040328"}, "abstract": "To assess the public's knowledge, attitudes and practices about the novel coronavirus in Sierra Leone to inform an evidence-based communication strategy around COVID-19.\r\n\r\nNationwide, cross-sectional Knowledge, Attitudes and Practices survey.\r\n\r\n56 randomly selected communities in all 14 districts in Sierra Leone.\r\n\r\n1253 adults aged 18 years and older of which 52% were men.\r\n\r\nWe calculated proportions of core indicators (awareness, knowledge, risk perception, practices). A composite variable for knowledge (based on seven variables) was created, and categorised into low (0-2 correct), medium (3-4) and high (5-7). Predictors of knowledge were analysed with multilevel ordinal regression models. Associations between information sources, knowledge and two practices (washing hands with soap and avoiding crowds) were analysed using multilevel logistic regression models.\r\n\r\nWe found that 75% of the respondents felt at moderate or great risk of contracting coronavirus. A majority (70%) of women did not know you can survive COVID-19, compared with 61% of men. 60% of men and 54% of women had already taken action to avoid infection with the coronavirus, mostly washing hands with soap and water (87%). Radio (73%) was the most used source for COVID-19 information, followed by social media (39%). Having a medium or high level of knowledge was associated with higher odds of washing hands with soap (medium knowledge: adjusted OR (AOR) 2.1, 95% CI 1.0 to 4.4; high knowledge: AOR 4.6, 95% CI 2.1 to 10.2) and avoiding crowds (medium knowledge: AOR 2.0, 95% CI 1.1 to 3.6; high knowledge: AOR 2.3, 95% CI 1.2 to 4.3).\r\n\r\nThis study shows that in the context of COVID-19 in Sierra Leone, there is a strong association between knowledge and practices. Because the knowledge gap differs between genders, regions, educational levels and age, it is important that messages are specifically targeted to these core audiences.", "doi": "10.1136/bmjopen-2020-040328", "pmid": "32948576", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "bmjopen-2020-040328"}, {"db": "pmc", "key": "PMC7500298"}], "notes": [], "created": "2020-12-03T15:25:05.492Z", "modified": "2022-11-10T06:29:42.518Z"}, {"entity": "publication", "iuid": "5dc281be97ab40e09602086957f75065", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5dc281be97ab40e09602086957f75065.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5dc281be97ab40e09602086957f75065"}}, "title": "Randomized elimination and prolongation of ACE inhibitors and ARBs in coronavirus 2019 (REPLACE COVID) Trial Protocol.", "authors": [{"family": "Cohen", "given": "Jordana B", "initials": "JB"}, {"family": "Hanff", "given": "Thomas C", "initials": "TC"}, {"family": "Corrales-Medina", "given": "Vicente", "initials": "V"}, {"family": "William", "given": "Preethi", "initials": "P"}, {"family": "Renna", "given": "Nicolas", "initials": "N"}, {"family": "Rosado-Santander", "given": "Nelson R", "initials": "NR"}, {"family": "Rodriguez-Mori", "given": "Juan E", "initials": "JE"}, {"family": "Spaak", "given": "Jonas", "initials": "J"}, {"family": "Andrade-Villanueva", "given": "Jaime", "initials": "J"}, {"family": "Chang", "given": "Tara I", "initials": "TI"}, {"family": "Barbagelata", "given": "Alejandro", "initials": "A"}, {"family": "Alfonso", "given": "Carlos E", "initials": "CE"}, {"family": "Bernales-Salas", "given": "Eduardo", "initials": "E"}, {"family": "Coacalla", "given": "Johanna", "initials": "J"}, {"family": "Castro-Callirgos", "given": "Carlos Augusto", "initials": "CA"}, {"family": "Tupayachi-Venero", "given": "Karen E", "initials": "KE"}, {"family": "Medina", "given": "Carola", "initials": "C"}, {"family": "Valdivia", "given": "Renzo", "initials": "R"}, {"family": "Villavicencio", "given": "Mirko", "initials": "M"}, {"family": "Vasquez", "given": "Charles R", "initials": "CR"}, {"family": "Harhay", "given": "Michael O", "initials": "MO"}, {"family": "Chittams", "given": "Jesse", "initials": "J"}, {"family": "Sharkoski", "given": "Tiffany", "initials": "T"}, {"family": "Byrd", "given": "James Brian", "initials": "JB"}, {"family": "Edmonston", "given": "Daniel L", "initials": "DL"}, {"family": "Sweitzer", "given": "Nancy", "initials": "N"}, {"family": "Chirinos", "given": "Julio A", "initials": "JA"}], "type": "journal article", "published": "2020-09-16", "journal": {"title": "J Clin Hypertens (Greenwich)", "issn": "1751-7176", "volume": null, "issue": null, "issn-l": "1524-6175"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), is associated with high incidence of multiorgan dysfunction and death. Angiotensin-converting enzyme 2 (ACE2), which facilitates SARS-CoV-2 host cell entry, may be impacted by angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), two commonly used antihypertensive classes. In a multicenter, international randomized controlled trial that began enrollment on March 31, 2020, participants are randomized to continuation vs withdrawal of their long-term outpatient ACEI or ARB upon hospitalization with COVID-19. The primary outcome is a hierarchical global rank score incorporating time to death, duration of mechanical ventilation, duration of renal replacement or vasopressor therapy, and multiorgan dysfunction severity. Approval for the study has been obtained from the Institutional Review Board of each participating institution, and all participants will provide informed consent. A data safety monitoring board has been assembled to provide independent oversight of the project.", "doi": "10.1111/jch.14011", "pmid": "32937008", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-26T14:07:07.090Z", "modified": "2020-11-27T12:42:14.575Z"}, {"entity": "publication", "iuid": "1b3238e3b30b41ffb504a180899ff5d9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b3238e3b30b41ffb504a180899ff5d9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b3238e3b30b41ffb504a180899ff5d9"}}, "title": "Correction to: Psychometric Validation of the Bangla Fear of COVID-19 Scale: Confirmatory Factor Analysis and Rasch Analysis.", "authors": [{"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA"}], "type": "journal article", "published": "2020-09-16", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "volume": null, "issue": null, "pages": "1-3", "issn-l": null}, "abstract": null, "doi": "10.1007/s11469-020-00399-6", "pmid": "32958998", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "399"}, {"db": "pmc", "key": "PMC7493694"}], "notes": [], "created": "2020-12-03T09:28:53.598Z", "modified": "2020-12-03T09:28:53.611Z"}, {"entity": "publication", "iuid": "36ef7db8e3064cca91e3a0646b84fbb5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/36ef7db8e3064cca91e3a0646b84fbb5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/36ef7db8e3064cca91e3a0646b84fbb5"}}, "title": "Estimating the impact of mobility patterns on COVID-19 infection rates in 11 European countries.", "authors": [{"family": "Bryant", "given": "Patrick", "initials": "P"}, {"family": "Elofsson", "given": "Arne", "initials": "A"}], "type": "journal article", "published": "2020-09-15", "journal": {"title": "PeerJ", "issn": "2167-8359", "issn-l": "2167-8359", "volume": "8", "issue": null, "pages": "e9879"}, "abstract": "As governments across Europe have issued non-pharmaceutical interventions (NPIs) such as social distancing and school closing, the mobility patterns in these countries have changed. Most states have implemented similar NPIs at similar time points. However, it is likely different countries and populations respond differently to the NPIs and that these differences cause mobility patterns and thereby the epidemic development to change.\r\n\r\nWe build a Bayesian model that estimates the number of deaths on a given day dependent on changes in the basic reproductive number, R0, due to differences in mobility patterns. We utilise mobility data from Google mobility reports using five different categories: retail and recreation, grocery and pharmacy, transit stations, workplace and residential. The importance of each mobility category for predicting changes in R0 is estimated through the model.\r\n\r\nThe changes in mobility have a considerable overlap with the introduction of governmental NPIs, highlighting the importance of government action for population behavioural change. The shift in mobility in all categories shows high correlations with the death rates 1 month later. Reduction of movement within the grocery and pharmacy sector is estimated to account for most of the decrease in R0.\r\n\r\nOur model predicts 3-week epidemic forecasts, using real-time observations of changes in mobility patterns, which can provide governments with direct feedback on the effects of their NPIs. The model predicts the changes in a majority of the countries accurately but overestimates the impact of NPIs in Sweden and Denmark and underestimates them in France and Belgium. We also note that the exponential nature of all epidemiological models based on the basic reproductive number, R0 cause small errors to have extensive effects on the predicted outcome.", "doi": "10.7717/peerj.9879", "pmid": "32983643", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://github.com/patrickbryant1/COVID19.github.io/tree/master/simulations/mobility", "description": "Modelling code and data"}], "notes": [], "created": "2020-10-30T12:05:16.028Z", "modified": "2021-02-26T08:45:48.044Z"}, {"entity": "publication", "iuid": "b5b2d03702cc482b86707ae25d5fac83", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b5b2d03702cc482b86707ae25d5fac83.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b5b2d03702cc482b86707ae25d5fac83"}}, "title": "Cloth Masks May Prevent Transmission of COVID-19: An Evidence-Based, Risk-Based Approach.", "authors": [{"family": "Clase", "given": "Catherine M", "initials": "CM"}, {"family": "Fu", "given": "Edouard L", "initials": "EL"}, {"family": "Joseph", "given": "Meera", "initials": "M"}, {"family": "Beale", "given": "Rupert C L", "initials": "RCL"}, {"family": "Dolovich", "given": "Myrna B", "initials": "MB"}, {"family": "Jardine", "given": "Meg", "initials": "M"}, {"family": "Mann", "given": "Johannes F E", "initials": "JFE"}, {"family": "Pecoits-Filho", "given": "Roberto", "initials": "R"}, {"family": "Winkelmayer", "given": "Wolfgang C", "initials": "WC"}, {"family": "Carrero", "given": "Juan J", "initials": "JJ"}], "type": "editorial", "published": "2020-09-15", "journal": {"title": "Ann Intern Med", "issn": "1539-3704", "volume": "173", "issue": "6", "pages": "489-491", "issn-l": "0003-4819"}, "abstract": null, "doi": "10.7326/M20-2567", "pmid": "32441991", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7277485"}], "notes": [], "created": "2020-11-25T09:12:11.027Z", "modified": "2020-12-09T11:33:38.890Z"}, {"entity": "publication", "iuid": "142a4622975548cca4f4ddbb2bfbcc1c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/142a4622975548cca4f4ddbb2bfbcc1c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/142a4622975548cca4f4ddbb2bfbcc1c"}}, "title": "Spatio-Temporal Mutational Profile Appearances of Swedish SARS-CoV-2 during the Early Pandemic.", "authors": [{"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Hickman", "given": "Rachel A", "initials": "RA"}, {"family": "Li", "given": "Jinlin", "initials": "J"}, {"family": "Lu", "given": "Xi", "initials": "X"}, {"family": "Lindahl", "given": "Johanna F", "initials": "JF"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}], "type": "journal article", "published": "2020-09-14", "journal": {"title": "Viruses", "issn": "1999-4915", "issn-l": "1999-4915", "volume": "12", "issue": "9", "pages": null}, "abstract": "During the COVID-19 pandemic, the virus evolved, and we therefore aimed to provide an insight into which genetic variants were enriched, and how they spread in Sweden.\r\n\r\nWe analyzed 348 Swedish SARS-CoV-2 sequences freely available from GISAID obtained from 7 February 2020 until 14 May 2020.\r\n\r\nWe identified 14 variant sites \u22655% frequency in the population. Among those sites, the D936Y substitution in the viral Spike protein was under positive selection. The variant sites can distinguish 11 mutational profiles in Sweden. Nine of the profiles appeared in Stockholm in March 2020. Mutational profiles 3 (B.1.1) and 6 (B.1), which contain the D936Y mutation, became the predominant profiles over time, spreading from Stockholm to other Swedish regions during April and the beginning of May. Furthermore, Bayesian phylogenetic analysis indicated that SARS-CoV-2 could have emerged in Sweden on 27 December 2019, and community transmission started on February 1st with an evolutionary rate of 1.5425 \u00d7 10 -3 substitutions per year.\r\n\r\nOur study provides novel knowledge on the spatio-temporal dynamics of Swedish SARS-CoV-2 variants during the early pandemic. Characterization of these viral variants can provide precious insights on viral pathogenesis and can be valuable for diagnostic and drug development approaches.", "doi": "10.3390/v12091026", "pmid": "32937868", "labels": {"Type: Journal article": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Drug discovery and repurposing of drugs": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "http://www.mdpi.com/1999-4915/12/9/1026/s1", "description": "Spatial temporal appearance of each variant and their mutation profile and clade information; Other supplementary materials."}], "notes": [], "created": "2020-10-28T09:08:27.508Z", "modified": "2021-06-13T14:21:08.152Z"}, {"entity": "publication", "iuid": "383eab77f1844350b33ce8258212261e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/383eab77f1844350b33ce8258212261e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/383eab77f1844350b33ce8258212261e"}}, "title": "Psychological Distress and Problem Gambling in Elite Athletes during COVID-19 Restrictions-A Web Survey in Top Leagues of Three Sports during the Pandemic.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "J\u00f6nsson", "given": "Caroline", "initials": "C"}, {"family": "Kentt\u00e4", "given": "G\u00f6ran", "initials": "G"}], "type": "journal article", "published": "2020-09-14", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "18", "pages": null}, "abstract": "COVID-19 and lockdown strategies may affect mental health and addictive behavior differently in the population, and elite athletes are among the professions clearly affected by the pandemic. This study in top elite athletes aimed to study current perceived psychological influence from COVID-19 and symptoms of depression, anxiety and changes in alcohol drinking, gambling behavior and problem gambling in the midst of the COVID-19 lockdown. This web survey included athletes in top leagues of soccer, ice hockey and handball in Sweden (N = 327, 62% men). A total of 66% and 51% were worried about the future of their sport or about their own future in sports, respectively. Feeling worse psychologically during the pandemic was common (72% of women, 40% of men, p < 0.001); depression criteria were endorsed by 19% of women and three percent of men (p < 0.001); anxiety criteria by 20% of women and five percent of men (p < 0.001). Reporting increased gambling during the pandemic was associated with gambling problem severity. Moderate-risk or problem gambling was seen in 10% of men and none of the women (p < 0.001). Depression and anxiety were associated with feeling worse during the COVID-19 pandemic and with concern over one's own sports future. In conclusion, COVID-19-related distress is common in elite athletes and associated with mental health symptoms. Gambling increase during the pandemic was rare, but related to gambling problems, which were common in male athletes. The calls for increased focus on COVID-19-related concerns in athletes and on problem gambling in male athletes.", "doi": "10.3390/ijerph17186693", "pmid": "32937978", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "ijerph17186693"}, {"db": "pmc", "key": "PMC7559357"}], "notes": [], "created": "2020-12-03T15:31:15.752Z", "modified": "2022-11-10T06:31:52.371Z"}, {"entity": "publication", "iuid": "6186d266f41a4cd995e5edb8ec12c8fd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6186d266f41a4cd995e5edb8ec12c8fd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6186d266f41a4cd995e5edb8ec12c8fd"}}, "title": "Pandemic programming: How COVID-19 affects software developers and how their organizations can help.", "authors": [{"family": "Ralph", "given": "Paul", "initials": "P"}, {"family": "Baltes", "given": "Sebastian", "initials": "S"}, {"family": "Adisaputri", "given": "Gianisa", "initials": "G"}, {"family": "Torkar", "given": "Richard", "initials": "R"}, {"family": "Kovalenko", "given": "Vladimir", "initials": "V"}, {"family": "Kalinowski", "given": "Marcos", "initials": "M"}, {"family": "Novielli", "given": "Nicole", "initials": "N"}, {"family": "Yoo", "given": "Shin", "initials": "S"}, {"family": "Devroey", "given": "Xavier", "initials": "X"}, {"family": "Tan", "given": "Xin", "initials": "X"}, {"family": "Zhou", "given": "Minghui", "initials": "M"}, {"family": "Turhan", "given": "Burak", "initials": "B"}, {"family": "Hoda", "given": "Rashina", "initials": "R"}, {"family": "Hata", "given": "Hideaki", "initials": "H"}, {"family": "Robles", "given": "Gregorio", "initials": "G"}, {"family": "Milani Fard", "given": "Amin", "initials": "A"}, {"family": "Alkadhi", "given": "Rana", "initials": "R"}], "type": "journal article", "published": "2020-09-14", "journal": {"title": "Empir Softw Eng", "issn": "1573-7616", "volume": null, "issue": null, "pages": "1-35", "issn-l": null}, "abstract": "As a novel coronavirus swept the world in early 2020, thousands of software developers began working from home. Many did so on short notice, under difficult and stressful conditions.\n\nThis study investigates the effects of the pandemic on developers' wellbeing and productivity.\n\nA questionnaire survey was created mainly from existing, validated scales and translated into 12 languages. The data was analyzed using non-parametric inferential statistics and structural equation modeling.\n\nThe questionnaire received 2225 usable responses from 53 countries. Factor analysis supported the validity of the scales and the structural model achieved a good fit (CFI = 0.961, RMSEA = 0.051, SRMR = 0.067). Confirmatory results include: (1) the pandemic has had a negative effect on developers' wellbeing and productivity; (2) productivity and wellbeing are closely related; (3) disaster preparedness, fear related to the pandemic and home office ergonomics all affect wellbeing or productivity. Exploratory analysis suggests that: (1) women, parents and people with disabilities may be disproportionately affected; (2) different people need different kinds of support.\n\nTo improve employee productivity, software companies should focus on maximizing employee wellbeing and improving the ergonomics of employees' home offices. Women, parents and disabled persons may require extra support.", "doi": "10.1007/s10664-020-09875-y", "pmid": "32952438", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "9875"}, {"db": "pmc", "key": "PMC7489196"}], "notes": [], "created": "2020-12-03T09:33:26.473Z", "modified": "2020-12-03T15:24:20.243Z"}, {"entity": "publication", "iuid": "0b5aef6454014621b5298e639210e0c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0b5aef6454014621b5298e639210e0c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0b5aef6454014621b5298e639210e0c9"}}, "title": "Shedding of infectious SARS-CoV-2 from airways in hospitalized COVID-19 patients in relation to serum antibody responses", "authors": [{"family": "Glans", "given": "Hedvig", "initials": "H"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Olausson", "given": "Mikaela", "initials": "M"}, {"family": "Falck-Jones", "given": "Sara", "initials": "S"}, {"family": "Varnaite", "given": "Renata", "initials": "R"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Maleki", "given": "Kimia T", "initials": "KT"}, {"family": "Lind Karlberg", "given": "Maria", "initials": "M"}, {"family": "Broddesson", "given": "Sandra", "initials": "S"}, {"family": "Falck-Jones", "given": "Ryan", "initials": "R"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Farnert", "given": "Anna", "initials": "A"}, {"family": "Smed Sorensen", "given": "Anna", "initials": "A"}, {"family": "Klingstrom", "given": "Jonas", "initials": "J"}, {"family": "Brave", "given": "Andreas", "initials": "A"}], "type": "posted-content", "published": "2020-09-13", "journal": {"title": "Infect Dis . 2020 Dec 10;20(1):942.", "issn": "1471-2334", "issn-l": null, "volume": "21", "issue": "1", "pages": "494"}, "abstract": "To understand the risk of transmission of SARS-CoV-2 in hospitalized COVID-19 patients we simultaneously assessed the presence of SARS-CoV-2 RNA, live infectious virus in the airways, and virus-specific IgG and neutralizing antibodies in sera in 36 hospitalized COVID-19 patients. SARS-CoV-2 could be cultured from four patients, all with low or undetectable antibody response. Our data suggests that the level of SARS-CoV-2 antibodies may correlate to risk for shedding live SARS-CoV-2 virus in hospitalized COVID-19 patients.", "doi": "10.1186/s12879-021-06202-8", "pmid": "34044758", "labels": {"Funder: VR": null, "Category: Genomics & transcriptomics": null, "Category: Health": null, "Type: Journal article": null, "Funder: Hj\u00e4rt-Lungfonden": null}, "xrefs": [], "notes": [], "created": "2020-10-29T12:35:34.869Z", "modified": "2021-11-18T08:50:56.330Z"}, {"entity": "publication", "iuid": "732dbf77b4de4598938e1ad6efc93392", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/732dbf77b4de4598938e1ad6efc93392.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/732dbf77b4de4598938e1ad6efc93392"}}, "title": "Guidance for the Management of Patients with Vascular Disease or Cardiovascular Risk Factors and COVID-19: Position Paper from VAS-European Independent Foundation in Angiology/Vascular Medicine.", "authors": [{"family": "Gerotziafas", "given": "Grigoris T", "initials": "GT"}, {"family": "Catalano", "given": "Mariella", "initials": "M"}, {"family": "Colgan", "given": "Mary-Paula", "initials": "MP"}, {"family": "Pecsvarady", "given": "Zsolt", "initials": "Z"}, {"family": "Wautrecht", "given": "Jean Claude", "initials": "JC"}, {"family": "Fazeli", "given": "Bahare", "initials": "B"}, {"family": "Olinic", "given": "Dan-Mircea", "initials": "DM"}, {"family": "Farkas", "given": "Katalin", "initials": "K"}, {"family": "Elalamy", "given": "Ismail", "initials": "I"}, {"family": "Falanga", "given": "Anna", "initials": "A"}, {"family": "Fareed", "given": "Jawed", "initials": "J"}, {"family": "Papageorgiou", "given": "Chryssa", "initials": "C"}, {"family": "Arellano", "given": "Rosella S", "initials": "RS"}, {"family": "Agathagelou", "given": "Petros", "initials": "P"}, {"family": "Antic", "given": "Darco", "initials": "D"}, {"family": "Auad", "given": "Luciana", "initials": "L"}, {"family": "Banfic", "given": "Ljiljana", "initials": "L"}, {"family": "Bartolomew", "given": "John R", "initials": "JR"}, {"family": "Benczur", "given": "Bela", "initials": "B"}, {"family": "Bernardo", "given": "Melissa B", "initials": "MB"}, {"family": "Boccardo", "given": "Francesco", "initials": "F"}, {"family": "Cifkova", "given": "Renate", "initials": "R"}, {"family": "Cosmi", "given": "Benilde", "initials": "B"}, {"family": "De Marchi", "given": "Sergio", "initials": "S"}, {"family": "Dimakakos", "given": "Evangelos", "initials": "E"}, {"family": "Dimopoulos", "given": "Meletios A", "initials": "MA"}, {"family": "Dimitrov", "given": "Gabriel", "initials": "G"}, {"family": "Durand-Zaleski", "given": "Isabelle", "initials": "I"}, {"family": "Edmonds", "given": "Michael", "initials": "M"}, {"family": "El Nazar", "given": "Essam Abo", "initials": "EA"}, {"family": "Erer", "given": "Dilek", "initials": "D"}, {"family": "Esponda", "given": "Omar L", "initials": "OL"}, {"family": "Gresele", "given": "Paolo", "initials": "P"}, {"family": "Gschwandtner", "given": "Michael", "initials": "M"}, {"family": "Gu", "given": "Yongquan", "initials": "Y"}, {"family": "Heinzmann", "given": "M\u00f3nica", "initials": "M"}, {"family": "Hamburg", "given": "Naomi M", "initials": "NM"}, {"family": "Hamad\u00e9", "given": "Amer", "initials": "A"}, {"family": "Jatoi", "given": "Noor-Ahmed", "initials": "NA"}, {"family": "Karahan", "given": "Oguz", "initials": "O"}, {"family": "Karetova", "given": "Debora", "initials": "D"}, {"family": "Karplus", "given": "Thomas", "initials": "T"}, {"family": "Klein-Weigel", "given": "Peter", "initials": "P"}, {"family": "Kolossvary", "given": "Endre", "initials": "E"}, {"family": "Kozak", "given": "Matija", "initials": "M"}, {"family": "Lefkou", "given": "Eleftheria", "initials": "E"}, {"family": "Lessiani", "given": "Gianfranco", "initials": "G"}, {"family": "Liew", "given": "Aaron", "initials": "A"}, {"family": "Marcoccia", "given": "Antonella", "initials": "A"}, {"family": "Marshang", "given": "Peter", "initials": "P"}, {"family": "Marakomichelakis", "given": "George", "initials": "G"}, {"family": "Matuska", "given": "Jiri", "initials": "J"}, {"family": "Moraglia", "given": "Luc", "initials": "L"}, {"family": "Pillon", "given": "Sergio", "initials": "S"}, {"family": "Poredos", "given": "Pavel", "initials": "P"}, {"family": "Prior", "given": "Manlio", "initials": "M"}, {"family": "Salvador", "given": "David Raymund K", "initials": "DRK"}, {"family": "Schlager", "given": "Oliver", "initials": "O"}, {"family": "Schernthaner", "given": "Gerit", "initials": "G"}, {"family": "Sieron", "given": "Alexander", "initials": "A"}, {"family": "Spaak", "given": "Jonas", "initials": "J"}, {"family": "Spyropoulos", "given": "Alex", "initials": "A"}, {"family": "Sprynger", "given": "Muriel", "initials": "M"}, {"family": "Suput", "given": "Dusan", "initials": "D"}, {"family": "Stanek", "given": "Agata", "initials": "A"}, {"family": "Stvrtinova", "given": "Viera", "initials": "V"}, {"family": "Szuba", "given": "Andrzej", "initials": "A"}, {"family": "Tafur", "given": "Alfonso", "initials": "A"}, {"family": "Vandreden", "given": "Patrick", "initials": "P"}, {"family": "Vardas", "given": "Panagiotis E", "initials": "PE"}, {"family": "Vasic", "given": "Dragan", "initials": "D"}, {"family": "Vikkula", "given": "Miikka", "initials": "M"}, {"family": "Wennberg", "given": "Paul", "initials": "P"}, {"family": "Zhai", "given": "Zhenguo", "initials": "Z"}, {"family": "Scientific Reviewer Committee", "given": "", "initials": ""}], "type": "journal article", "published": "2020-09-13", "journal": {"title": "Thromb Haemost", "issn": "2567-689X", "volume": null, "issue": null, "issn-l": "0340-6245"}, "abstract": "COVID-19 is also manifested with hypercoagulability, pulmonary intravascular coagulation, microangiopathy, and venous thromboembolism (VTE) or arterial thrombosis. Predisposing risk factors to severe COVID-19 are male sex, underlying cardiovascular disease, or cardiovascular risk factors including noncontrolled diabetes mellitus or arterial hypertension, obesity, and advanced age. The VAS-European Independent Foundation in Angiology/Vascular Medicine draws attention to patients with vascular disease (VD) and presents an integral strategy for the management of patients with VD or cardiovascular risk factors (VD-CVR) and COVID-19. VAS recommends (1) a COVID-19-oriented primary health care network for patients with VD-CVR for identification of patients with VD-CVR in the community and patients' education for disease symptoms, use of eHealth technology, adherence to the antithrombotic and vascular regulating treatments, and (2) close medical follow-up for efficacious control of VD progression and prompt application of physical and social distancing measures in case of new epidemic waves. For patients with VD-CVR who receive home treatment for COVID-19, VAS recommends assessment for (1) disease worsening risk and prioritized hospitalization of those at high risk and (2) VTE risk assessment and thromboprophylaxis with rivaroxaban, betrixaban, or low-molecular-weight heparin (LMWH) for those at high risk. For hospitalized patients with VD-CVR and COVID-19, VAS recommends (1) routine thromboprophylaxis with weight-adjusted intermediate doses of LMWH (unless contraindication); (2) LMWH as the drug of choice over unfractionated heparin or direct oral anticoagulants for the treatment of VTE or hypercoagulability; (3) careful evaluation of the risk for disease worsening and prompt application of targeted antiviral or convalescence treatments; (4) monitoring of D-dimer for optimization of the antithrombotic treatment; and (5) evaluation of the risk of VTE before hospital discharge using the IMPROVE-D-dimer score and prolonged post-discharge thromboprophylaxis with rivaroxaban, betrixaban, or LMWH.", "doi": "10.1055/s-0040-1715798", "pmid": "32920811", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-03T15:37:40.375Z", "modified": "2020-12-03T15:38:41.229Z"}, {"entity": "publication", "iuid": "87e3177a4f144265bc03fab88fd9a870", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/87e3177a4f144265bc03fab88fd9a870.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/87e3177a4f144265bc03fab88fd9a870"}}, "title": "Zoonotic Diseases: Etiology, Impact, and Control.", "authors": [{"family": "Rahman", "given": "Md Tanvir", "initials": "MT"}, {"family": "Sobur", "given": "Md Abdus", "initials": "MA"}, {"family": "Islam", "given": "Md Saiful", "initials": "MS"}, {"family": "Ievy", "given": "Samina", "initials": "S"}, {"family": "Hossain", "given": "Md Jannat", "initials": "MJ"}, {"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME"}, {"family": "Rahman", "given": "Amm Taufiquer", "initials": "AT"}, {"family": "Ashour", "given": "Hossam M", "initials": "HM"}], "type": "journal article", "published": "2020-09-12", "journal": {"title": "Microorganisms", "issn": "2076-2607", "volume": "8", "issue": "9", "pages": null, "issn-l": "2076-2607"}, "abstract": "Most humans are in contact with animals in a way or another. A zoonotic disease is a disease or infection that can be transmitted naturally from vertebrate animals to humans or from humans to vertebrate animals. More than 60% of human pathogens are zoonotic in origin. This includes a wide variety of bacteria, viruses, fungi, protozoa, parasites, and other pathogens. Factors such as climate change, urbanization, animal migration and trade, travel and tourism, vector biology, anthropogenic factors, and natural factors have greatly influenced the emergence, re-emergence, distribution, and patterns of zoonoses. As time goes on, there are more emerging and re-emerging zoonotic diseases. In this review, we reviewed the etiology of major zoonotic diseases, their impact on human health, and control measures for better management. We also highlighted COVID-19, a newly emerging zoonotic disease of likely bat origin that has affected millions of humans along with devastating global consequences. The implementation of One Health measures is highly recommended for the effective prevention and control of possible zoonosis.", "doi": "10.3390/microorganisms8091405", "pmid": "32932606", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "microorganisms8091405"}, {"db": "pmc", "key": "PMC7563794"}], "notes": [], "created": "2020-11-22T09:35:07.748Z", "modified": "2020-12-03T15:33:04.091Z"}, {"entity": "publication", "iuid": "cea2db86142e40b78905aca930630de3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cea2db86142e40b78905aca930630de3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cea2db86142e40b78905aca930630de3"}}, "title": "Response to the Novel Corona Virus (COVID-19) Pandemic Across Africa: Successes, Challenges, and Implications for the Future.", "authors": [{"family": "Ogunleye", "given": "Olayinka O", "initials": "OO"}, {"family": "Basu", "given": "Debashis", "initials": "D"}, {"family": "Mueller", "given": "Debjani", "initials": "D"}, {"family": "Sneddon", "given": "Jacqueline", "initials": "J"}, {"family": "Seaton", "given": "R Andrew", "initials": "RA"}, {"family": "Yinka-Ogunleye", "given": "Adesola F", "initials": "AF"}, {"family": "Wamboga", "given": "Joshua", "initials": "J"}, {"family": "Miljkovi\u0107", "given": "Nenad", "initials": "N"}, {"family": "Mwita", "given": "Julius C", "initials": "JC"}, {"family": "Rwegerera", "given": "Godfrey Mutashambara", "initials": "GM"}, {"family": "Massele", "given": "Amos", "initials": "A"}, {"family": "Patrick", "given": "Okwen", "initials": "O"}, {"family": "Niba", "given": "Loveline Lum", "initials": "LL"}, {"family": "Nsaikila", "given": "Melaine", "initials": "M"}, {"family": "Rashed", "given": "Wafaa M", "initials": "WM"}, {"family": "Hussein", "given": "Mohamed Ali", "initials": "MA"}, {"family": "Hegazy", "given": "Rehab", "initials": "R"}, {"family": "Amu", "given": "Adefolarin A", "initials": "AA"}, {"family": "Boahen-Boaten", "given": "Baffour Boaten", "initials": "BB"}, {"family": "Matsebula", "given": "Zinhle", "initials": "Z"}, {"family": "Gwebu", "given": "Prudence", "initials": "P"}, {"family": "Chirigo", "given": "Bongani", "initials": "B"}, {"family": "Mkhabela", "given": "Nongabisa", "initials": "N"}, {"family": "Dlamini", "given": "Tenelisiwe", "initials": "T"}, {"family": "Sithole", "given": "Siphiwe", "initials": "S"}, {"family": "Malaza", "given": "Sandile", "initials": "S"}, {"family": "Dlamini", "given": "Sikhumbuzo", "initials": "S"}, {"family": "Afriyie", "given": "Daniel", "initials": "D"}, {"family": "Asare", "given": "George Awuku", "initials": "GA"}, {"family": "Amponsah", "given": "Seth Kwabena", "initials": "SK"}, {"family": "Sefah", "given": "Israel", "initials": "I"}, {"family": "Oluka", "given": "Margaret", "initials": "M"}, {"family": "Guantai", "given": "Anastasia N", "initials": "AN"}, {"family": "Opanga", "given": "Sylvia A", "initials": "SA"}, {"family": "Sarele", "given": "Tebello Violet", "initials": "TV"}, {"family": "Mafisa", "given": "Refeletse Keabetsoe", "initials": "RK"}, {"family": "Chikowe", "given": "Ibrahim", "initials": "I"}, {"family": "Khuluza", "given": "Felix", "initials": "F"}, {"family": "Kibuule", "given": "Dan", "initials": "D"}, {"family": "Kalemeera", "given": "Francis", "initials": "F"}, {"family": "Mubita", "given": "Mwangana", "initials": "M"}, {"family": "Fadare", "given": "Joseph", "initials": "J"}, {"family": "Sibomana", "given": "Laurien", "initials": "L"}, {"family": "Ramokgopa", "given": "Gwendoline Malegwale", "initials": "GM"}, {"family": "Whyte", "given": "Carmen", "initials": "C"}, {"family": "Maimela", "given": "Tshegofatso", "initials": "T"}, {"family": "Hugo", "given": "Johannes", "initials": "J"}, {"family": "Meyer", "given": "Johanna C", "initials": "JC"}, {"family": "Schellack", "given": "Natalie", "initials": "N"}, {"family": "Rampamba", "given": "Enos M", "initials": "EM"}, {"family": "Visser", "given": "Adel", "initials": "A"}, {"family": "Alfadl", "given": "Abubakr", "initials": "A"}, {"family": "Malik", "given": "Elfatih M", "initials": "EM"}, {"family": "Malande", "given": "Oliver Ombeva", "initials": "OO"}, {"family": "Kalungia", "given": "Aubrey C", "initials": "AC"}, {"family": "Mwila", "given": "Chiluba", "initials": "C"}, {"family": "Zaranyika", "given": "Trust", "initials": "T"}, {"family": "Chaibva", "given": "Blessmore Vimbai", "initials": "BV"}, {"family": "Olaru", "given": "Ioana D", "initials": "ID"}, {"family": "Masuka", "given": "Nyasha", "initials": "N"}, {"family": "Wale", "given": "Janney", "initials": "J"}, {"family": "Hwenda", "given": "Lenias", "initials": "L"}, {"family": "Kamoga", "given": "Regina", "initials": "R"}, {"family": "Hill", "given": "Ruaraidh", "initials": "R"}, {"family": "Barbui", "given": "Corrado", "initials": "C"}, {"family": "Bochenek", "given": "Tomasz", "initials": "T"}, {"family": "Kurdi", "given": "Amanj", "initials": "A"}, {"family": "Campbell", "given": "Stephen", "initials": "S"}, {"family": "Martin", "given": "Antony P", "initials": "AP"}, {"family": "Phuong", "given": "Thuy Nguyen Thi", "initials": "TNT"}, {"family": "Thanh", "given": "Binh Nguyen", "initials": "BN"}, {"family": "Godman", "given": "Brian", "initials": "B"}], "type": "journal article", "published": "2020-09-11", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "11", "issue": null, "pages": "1205", "issn-l": "1663-9812"}, "abstract": "The COVID-19 pandemic has already claimed considerable lives. There are major concerns in Africa due to existing high prevalence rates for both infectious and non-infectious diseases and limited resources in terms of personnel, beds and equipment. Alongside this, concerns that lockdown and other measures will have on prevention and management of other infectious diseases and non-communicable diseases (NCDs). NCDs are an increasing issue with rising morbidity and mortality rates. The World Health Organization (WHO) warns that a lack of nets and treatment could result in up to 18 million additional cases of malaria and up to 30,000 additional deaths in sub-Saharan Africa.\n\nDocument current prevalence and mortality rates from COVID-19 alongside economic and other measures to reduce its spread and impact across Africa. In addition, suggested ways forward among all key stakeholder groups.\n\nContextualise the findings from a wide range of publications including internet-based publications coupled with input from senior-level personnel.\n\nPrevalence and mortality rates are currently lower in Africa than among several Western countries and the USA. This could be due to a number of factors including early instigation of lockdown and border closures, the younger age of the population, lack of robust reporting systems and as yet unidentified genetic and other factors. Innovation is accelerating to address concerns with available equipment. There are ongoing steps to address the level of misinformation and its consequences including fines. There are also ongoing initiatives across Africa to start addressing the unintended consequences of COVID-19 activities including lockdown measures and their impact on NCDs including the likely rise in mental health disorders, exacerbated by increasing stigma associated with COVID-19. Strategies include extending prescription lengths, telemedicine and encouraging vaccination. However, these need to be accelerated to prevent increased morbidity and mortality.\n\nThere are multiple activities across Africa to reduce the spread of COVID-19 and address misinformation, which can have catastrophic consequences, assisted by the WHO and others, which appear to be working in a number of countries. Research is ongoing to clarify the unintended consequences given ongoing concerns to guide future activities. Countries are learning from each other.", "doi": "10.3389/fphar.2020.01205", "pmid": "33071775", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7533592"}], "notes": [], "created": "2020-11-26T12:24:30.995Z", "modified": "2020-11-26T12:24:31.017Z"}, {"entity": "publication", "iuid": "23b3b226c1804746af8f9473c4c7563f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23b3b226c1804746af8f9473c4c7563f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23b3b226c1804746af8f9473c4c7563f"}}, "title": "Piecewise quadratic growth during the 2019 novel coronavirus epidemic.", "authors": [{"family": "Brandenburg", "given": "Axel", "initials": "A"}], "type": "journal article", "published": "2020-09-11", "journal": {"title": "Infect Dis Model", "issn": "2468-0427", "volume": "5", "issue": null, "pages": "681-690", "issn-l": null}, "abstract": "The temporal growth in the number of deaths in the COVID-19 epidemic is subexponential. Here we show that a piecewise quadratic law provides an excellent fit during the thirty days after the first three fatalities on January 20 and later since the end of March 2020. There is also a brief intermediate period of exponential growth. During the second quadratic growth phase, the characteristic time of the growth is about eight times shorter than in the beginning, which can be understood as the occurrence of separate hotspots. Quadratic behavior can be motivated by peripheral growth when further spreading occurs only on the outskirts of an infected region. We also study numerical solutions of a simple epidemic model, where the spatial extend of the system is taken into account. To model the delayed onset outside China together with the early one in China within a single model with minimal assumptions, we adopt an initial condition of several hotspots, of which one reaches saturation much earlier than the others. At each site, quadratic growth commences when the local number of infections has reached a certain saturation level. The total number of deaths does then indeed follow a piecewise quadratic behavior.", "doi": "10.1016/j.idm.2020.08.014", "pmid": "32954094", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2468-0427(20)30044-0"}, {"db": "pmc", "key": "PMC7485523"}], "notes": [], "created": "2020-12-03T09:33:11.690Z", "modified": "2020-12-03T09:33:11.704Z"}, {"entity": "publication", "iuid": "1ec555708e424f25a0d57786d6bd022e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ec555708e424f25a0d57786d6bd022e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ec555708e424f25a0d57786d6bd022e"}}, "title": "Development, clinical translation, and utility of a COVID-19 antibody test with qualitative and quantitative readouts.", "authors": [{"family": "Bortz", "given": "Robert H", "initials": "RH"}, {"family": "Florez", "given": "Catalina", "initials": "C"}, {"family": "Laudermilch", "given": "Ethan", "initials": "E"}, {"family": "Wirchnianski", "given": "Ariel S", "initials": "AS"}, {"family": "Lasso", "given": "Gorka", "initials": "G"}, {"family": "Malonis", "given": "Ryan J", "initials": "RJ"}, {"family": "Georgiev", "given": "George I", "initials": "GI"}, {"family": "Vergnolle", "given": "Olivia", "initials": "O"}, {"family": "Herrera", "given": "Natalia G", "initials": "NG"}, {"family": "Morano", "given": "Nicholas C", "initials": "NC"}, {"family": "Campbell", "given": "Sean T", "initials": "ST"}, {"family": "Orner", "given": "Erika P", "initials": "EP"}, {"family": "Mengotto", "given": "Amanda", "initials": "A"}, {"family": "Dieterle", "given": "M Eugenia", "initials": "ME"}, {"family": "Fels", "given": "Jens Maximilian", "initials": "JM"}, {"family": "Haslwanter", "given": "Denise", "initials": "D"}, {"family": "Jangra", "given": "Rohit", "initials": "R"}, {"family": "Celikgil", "given": "Alev", "initials": "A"}, {"family": "Kimmel", "given": "Duncan", "initials": "D"}, {"family": "Lee", "given": "James H", "initials": "JH"}, {"family": "Mariano", "given": "Margarette", "initials": "M"}, {"family": "Nakouzi", "given": "Antonio", "initials": "A"}, {"family": "Quiroz", "given": "Jose", "initials": "J"}, {"family": "Rivera", "given": "Johanna", "initials": "J"}, {"family": "Szymczak", "given": "Wendy A", "initials": "WA"}, {"family": "Tong", "given": "Karen", "initials": "K"}, {"family": "Barnhill", "given": "Jason", "initials": "J"}, {"family": "Forsell", "given": "Mattias Ne", "initials": "MN"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Stein", "given": "Daniel T", "initials": "DT"}, {"family": "Pirofski", "given": "Liise-Anne", "initials": "L"}, {"family": "Goldstein", "given": "Doctor Y", "initials": "DY"}, {"family": "Garforth", "given": "Scott J", "initials": "SJ"}, {"family": "Almo", "given": "Steven C", "initials": "SC"}, {"family": "Daily", "given": "Johanna P", "initials": "JP"}, {"family": "Prystowsky", "given": "Michael B", "initials": "MB"}, {"family": "Faix", "given": "James D", "initials": "JD"}, {"family": "Fox", "given": "Amy S", "initials": "AS"}, {"family": "Weiss", "given": "Louis M", "initials": "LM"}, {"family": "Lai", "given": "Jonathan R", "initials": "JR"}, {"family": "Chandran", "given": "Kartik", "initials": "K"}], "type": "preprint", "published": "2020-09-11", "journal": {"title": "mSphere", "issn": "2379-5042", "issn-l": null, "volume": "6", "issue": "2", "pages": null}, "abstract": "The COVID-19 global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to place an immense burden on societies and healthcare systems. A key component of COVID-19 control efforts is serologic testing to determine the community prevalence of SARS-CoV-2 exposure and quantify individual immune responses to prior infection or vaccination. Here, we describe a laboratory-developed antibody test that uses readily available research-grade reagents to detect SARS-CoV-2 exposure in patient blood samples with high sensitivity and specificity. We further show that this test affords the estimation of viral spike-specific IgG titers from a single sample measurement, thereby providing a simple and scalable method to measure the strength of an individual's immune response. The accuracy, adaptability, and cost-effectiveness of this test makes it an excellent option for clinical deployment in the ongoing COVID-19 pandemic.", "doi": "10.1128/mSphere.00224-21", "pmid": null, "labels": {"Category: Biochemistry": null, "Category: Health": null, "Category: Serology": null, "Category: Proteins": null, "Type: Journal article": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-11-04T15:35:31.660Z", "modified": "2021-04-23T04:34:32.198Z"}, {"entity": "publication", "iuid": "44c735f6e3364a05a857311d3471133b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/44c735f6e3364a05a857311d3471133b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/44c735f6e3364a05a857311d3471133b"}}, "title": "Can intravenous oxytocin infusion counteract hyperinflammation in COVID-19 infected patients?", "authors": [{"family": "Buemann", "given": "Benjamin", "initials": "B"}, {"family": "Marazziti", "given": "Donatella", "initials": "D"}, {"family": "Uvn\u00e4s-Moberg", "given": "Kerstin", "initials": "K"}], "type": "journal article", "published": "2020-09-11", "journal": {"title": "World J Biol Psychiatry", "issn": "1814-1412", "volume": null, "issue": null, "pages": "1-12", "issn-l": null}, "abstract": "Based on its well-documented anti-inflammatory and restorative properties we propose trials with the natural hormone oxytocin for treatment of hospitalised Covid-19 patients.\n\nWe searched for, retrieved, and commented on specific literature regarding multiple functions of oxytocin with a special focus on its modulation of inflammatory, immune, and restorative functions.\n\nAvailable data gathered in animals and humans support the anti-inflammatory properties of oxytocin. The multiple anti-inflammatory effects of oxytocin have been demonstrated in vitro and in vivo in various animal models and also in humans in response to intravenous infusion of oxytocin. Furthermore, oxytocin has been documented to activate several types of protective and restorative mechanisms and to exert positive effects on the immune system.\n\nIn addition, to being anti-inflammatory, it may be hypothesised, that oxytocin may be less suppressive on adaptive immune systems, as compared with glucocorticoids. Finally, by its restorative effects coupled with its anti-stress and healing properties, oxytocin may shorten the recovery period of the Covid-19 patients.", "doi": "10.1080/15622975.2020.1814408", "pmid": "32914674", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-03T15:50:41.427Z", "modified": "2020-12-03T15:50:41.437Z"}, {"entity": "publication", "iuid": "c0dccb4b5d464861a2edc7e0621fa33f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c0dccb4b5d464861a2edc7e0621fa33f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c0dccb4b5d464861a2edc7e0621fa33f"}}, "title": "Covid-19 as cultural trauma.", "authors": [{"family": "Demertzis", "given": "Nicolas", "initials": "N"}, {"family": "Eyerman", "given": "Ron", "initials": "R"}], "type": "journal article", "published": "2020-09-10", "journal": {"title": "Am J Cult Sociol", "issn": "2049-7113", "volume": null, "issue": null, "pages": "1-23", "issn-l": null}, "abstract": "This paper has two aims. The first is to introduce the concept of compressed cultural trauma, and the second is to apply the theory of cultural trauma in two case studies of the current covid-19 pandemic, Greece and Sweden. Our central question is whether the pandemic will evolve into a cultural trauma in these two countries. We believe the pandemic presents a challenge to cultural trauma theory, which the idea of compressed trauma is meant to address. We conclude that, while the ongoing covid-19 pandemic has had traumatic consequences in Sweden and Greece, it has not evolved into cultural trauma in either country.", "doi": "10.1057/s41290-020-00112-z", "pmid": "32929388", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "112"}, {"db": "pmc", "key": "PMC7481543"}], "notes": [], "created": "2020-12-03T15:35:12.134Z", "modified": "2020-12-03T15:35:12.159Z"}, {"entity": "publication", "iuid": "2edf22a701b24f3a9e15b94b30781900", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2edf22a701b24f3a9e15b94b30781900.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2edf22a701b24f3a9e15b94b30781900"}}, "title": "COVID-19 Pandemic Control: Lessons Learned From Hai Phong City, Vietnam.", "authors": [{"family": "Tran", "given": "Thanh Chi", "initials": "TC"}, {"family": "Ngo", "given": "The Anh", "initials": "TA"}, {"family": "Nguyen", "given": "Thanh Duc", "initials": "TD"}, {"family": "Olson", "given": "Linus", "initials": "L"}, {"family": "Larsson", "given": "Mattias", "initials": "M"}], "type": "journal article", "published": "2020-09-10", "journal": {"title": "Asia Pac J Public Health", "issn": "1941-2479", "volume": null, "issue": null, "pages": "1010539520956424", "issn-l": null}, "abstract": "The COVID-19 (coronavirus disease-2019) pandemic has affected almost all countries in the world. When the first cases were reported from Hubei, China, in late December 2019, the Vietnamese authorities acknowledged the potential risk of an epidemic having had the experience of severe acute respiratory syndrome (SARS) and the Avian flu. When it was clear that there was human-to-human transmission in the epidemic in Wuhan that started in January 2020, the Vietnamese government, health care system, and civil society were rapidly mobilized. How has a country with a population of about 100 million and a long porous border to China managed to prevent a larger outbreak? This case history is about how Hai Phong city implemented the initial COVID-19 response. Hai Phong reacted quickly after the COVID-19 outbreak in China by, quarantining people coming from pandemic areas, and carrying out contact tracing and extensive testing, closing schools and universities and implementing two weeks of social distancing measures. There are no detected positive cases until May 18, 2020 in Hai Phong.", "doi": "10.1177/1010539520956424", "pmid": "32909472", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-03T15:51:38.418Z", "modified": "2020-12-03T15:51:38.442Z"}, {"entity": "publication", "iuid": "56b0b53e67ce45b68fad60337e0aa7a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56b0b53e67ce45b68fad60337e0aa7a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56b0b53e67ce45b68fad60337e0aa7a6"}}, "title": "Is COVID-19 spreading and curing silently: an observation of three family clusters in Bangladesh.", "authors": [{"family": "Hoq", "given": "Mohammad Injamul", "initials": "MI"}, {"family": "Hossain", "given": "Md Mohotasin", "initials": "MM"}, {"family": "Roshni", "given": "Umme Sayma", "initials": "US"}, {"family": "Sayeed", "given": "Mohammed Aktar", "initials": "MA"}, {"family": "Tohura", "given": "Saraban", "initials": "S"}, {"family": "Jakaria", "given": "Md", "initials": "M"}], "type": "case reports", "published": "2020-09-09", "journal": {"title": "J Basic Clin Physiol Pharmacol", "issn": "2191-0286", "issn-l": null, "volume": "31", "issue": "6", "pages": null}, "abstract": "Objectives The number of coronavirus disease (COVID-19) cases is increasing in Bangladesh. Many people have suffered from symptoms like COVID-19 during this pandemic, and some people have cured without taking any treatment or taking minor pharmacological and non-pharmacological treatments. However, they might be spreading their infections among their family members and perhaps in the community. It is unsure that individuals with COVID-19-like symptoms are positive with COVID-19, but our concern is, during this pandemic, any types of symptoms such as flu-like symptoms should have been taken seriously. This study was observed in the cases from three families with COVID-19 like symptoms. Case presentation This observational study was done between May 20 and Jun 2, 2020, in Bangladesh. The members of the inspected families shared COVID-19 like symptoms that were lasted for 3-10 days. Conclusions COVID-19 might be spread and cured silently in Bangladesh, which recommends that awareness is needed throughout the country to prevent the spreading of the disease.", "doi": "10.1515/jbcpp-2020-0224", "pmid": "32903208", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "/j/jbcpp.ahead-of-print/jbcpp-2020-0224/jbcpp-2020-0224.xml"}], "notes": [], "created": "2020-12-03T16:16:25.822Z", "modified": "2022-11-10T06:39:33.321Z"}, {"entity": "publication", "iuid": "eb78f8ab3f6c40afbc9c4dbb77e7d827", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb78f8ab3f6c40afbc9c4dbb77e7d827.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb78f8ab3f6c40afbc9c4dbb77e7d827"}}, "title": "What do people hospitalised with covid-19 think about the care they received?", "authors": [{"family": "Wu", "given": "Meng-San", "initials": "MS"}, {"family": "Hayat", "given": "Fatima", "initials": "F"}, {"family": "Ratcliffe", "given": "Libuse", "initials": "L"}, {"family": "Beadsworth", "given": "Mike B J", "initials": "MBJ"}, {"family": "Defres", "given": "Sylviane", "initials": "S"}, {"family": "Wingfield", "given": "Tom", "initials": "T"}], "type": "letter", "published": "2020-09-08", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "370", "issue": null, "pages": "m3496", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m3496", "pmid": "32900791", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-06T07:15:59.881Z", "modified": "2020-12-06T07:16:27.079Z"}, {"entity": "publication", "iuid": "6f64f5b4044d4dad891fbcc8cae95651", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6f64f5b4044d4dad891fbcc8cae95651.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6f64f5b4044d4dad891fbcc8cae95651"}}, "title": "The influence of sex and gender domains on COVID-19 cases and mortality.", "authors": [{"family": "Tadiri", "given": "Christina P", "initials": "CP"}, {"family": "Gisinger", "given": "Teresa", "initials": "T"}, {"family": "Kautzy-Willer", "given": "Alexandra", "initials": "A"}, {"family": "Kublickiene", "given": "Karolina", "initials": "K"}, {"family": "Herrero", "given": "Maria Trinidad", "initials": "MT"}, {"family": "Raparelli", "given": "Valeria", "initials": "V"}, {"family": "Pilote", "given": "Louise", "initials": "L"}, {"family": "Norris", "given": "Colleen M", "initials": "CM"}, {"family": "GOING-FWD Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2020-09-08", "journal": {"title": "CMAJ", "issn": "1488-2329", "volume": "192", "issue": "36", "pages": "E1041-E1045", "issn-l": null}, "abstract": null, "doi": "10.1503/cmaj.200971", "pmid": "32900766", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "192/36/E1041"}, {"db": "pmc", "key": "PMC7504881"}], "notes": [], "created": "2020-12-06T07:20:20.362Z", "modified": "2020-12-06T07:20:20.386Z"}, {"entity": "publication", "iuid": "3a3b8e0c4e7c43e9aac18620677bfd64", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a3b8e0c4e7c43e9aac18620677bfd64.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a3b8e0c4e7c43e9aac18620677bfd64"}}, "title": "Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates.", "authors": [{"family": "Damas", "given": "Joana", "initials": "J", "orcid": "0000-0003-4857-2510", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d86c6ce3efc8438cb022b0a6116ec808.json"}}, {"family": "Hughes", "given": "Graham M", "initials": "GM", "orcid": "0000-0003-3088-345X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a7cca5ad139542a09d41aacc87cef194.json"}}, {"family": "Keough", "given": "Kathleen C", "initials": "KC", "orcid": "0000-0002-7481-0511", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/31418e90941f44ed9f7baac2fc2b0ca5.json"}}, {"family": "Painter", "given": "Corrie A", "initials": "CA", "orcid": "0000-0001-6174-1548", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b93e610d9a7448d2b1b04013fee689e3.json"}}, {"family": "Persky", "given": "Nicole S", "initials": "NS", "orcid": "0000-0002-9948-2761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b64350d9c0a406396b36eabd6c372c4.json"}}, {"family": "Corbo", "given": "Marco", "initials": "M", "orcid": "0000-0002-4566-2724", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/67850769221d40e3bc798c393b4f559f.json"}}, {"family": "Hiller", "given": "Michael", "initials": "M", "orcid": "0000-0003-3024-1449", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/74b8c53343314dde971b5f1d9ba7adc4.json"}}, {"family": "Koepfli", "given": "Klaus-Peter", "initials": "KP", "orcid": "0000-0001-7281-0676", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb8ddd52615d4685adb7985d9a79f361.json"}}, {"family": "Pfenning", "given": "Andreas R", "initials": "AR", "orcid": "0000-0002-3447-9801", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35a8a125b8ba47378aa05db0f82c774b.json"}}, {"family": "Zhao", "given": "Huabin", "initials": "H", "orcid": "0000-0002-7848-6392", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2ff10d2b3b3c4465ae9edf8d8e270fd9.json"}}, {"family": "Genereux", "given": "Diane P", "initials": "DP", "orcid": "0000-0001-5770-0989", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/59c3f0cfa3bf46f58e5ee2d98a935a2c.json"}}, {"family": "Swofford", "given": "Ross", "initials": "R", "orcid": "0000-0003-3676-8479", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9e4973c0096a496fb46269c0d1e1e8d1.json"}}, {"family": "Pollard", "given": "Katherine S", "initials": "KS", "orcid": "0000-0002-9870-6196", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5281b158f9334e39a18cfb618cd1f6fc.json"}}, {"family": "Ryder", "given": "Oliver A", "initials": "OA", "orcid": "0000-0003-2427-763X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8e2fd53a69c14ea0a555a974df5186f1.json"}}, {"family": "Nweeia", "given": "Martin T", "initials": "MT", "orcid": "0000-0001-7079-4123", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12f0f63b2b3545f8a6f76bdf9c9c10b3.json"}}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K", "orcid": "0000-0001-8338-0253", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/159b64d0fe104764b779588736155088.json"}}, {"family": "Teeling", "given": "Emma C", "initials": "EC", "orcid": "0000-0002-3309-1346", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a9c530af6e24c07931ae16eed8fd5ed.json"}}, {"family": "Karlsson", "given": "Elinor K", "initials": "EK", "orcid": "0000-0002-4343-3776", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1ff1d0b875064bc9b8c54d5af01ec13c.json"}}, {"family": "Lewin", "given": "Harris A", "initials": "HA", "orcid": "0000-0002-1043-7287", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8feb3ed5d3a14dea95ed77742bd1e569.json"}}], "type": "comparative study", "published": "2020-09-08", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "117", "issue": "36", "pages": "22311-22322", "issn-l": "0027-8424"}, "abstract": "The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19. The main receptor of SARS-CoV-2, angiotensin I converting enzyme 2 (ACE2), is now undergoing extensive scrutiny to understand the routes of transmission and sensitivity in different species. Here, we utilized a unique dataset of ACE2 sequences from 410 vertebrate species, including 252 mammals, to study the conservation of ACE2 and its potential to be used as a receptor by SARS-CoV-2. We designed a five-category binding score based on the conservation properties of 25 amino acids important for the binding between ACE2 and the SARS-CoV-2 spike protein. Only mammals fell into the medium to very high categories and only catarrhine primates into the very high category, suggesting that they are at high risk for SARS-CoV-2 infection. We employed a protein structural analysis to qualitatively assess whether amino acid changes at variable residues would be likely to disrupt ACE2/SARS-CoV-2 spike protein binding and found the number of predicted unfavorable changes significantly correlated with the binding score. Extending this analysis to human population data, we found only rare (frequency <0.001) variants in 10/25 binding sites. In addition, we found significant signals of selection and accelerated evolution in the ACE2 coding sequence across all mammals, and specific to the bat lineage. Our results, if confirmed by additional experimental data, may lead to the identification of intermediate host species for SARS-CoV-2, guide the selection of animal models of COVID-19, and assist the conservation of animals both in native habitats and in human care.", "doi": "10.1073/pnas.2010146117", "pmid": "32826334", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7486773"}, {"db": "pii", "key": "2010146117"}], "notes": [], "created": "2020-12-07T11:52:39.925Z", "modified": "2023-06-19T14:38:30.044Z"}, {"entity": "publication", "iuid": "3e9b231b9d9a4b1d837d4b4ebf1662db", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3e9b231b9d9a4b1d837d4b4ebf1662db.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3e9b231b9d9a4b1d837d4b4ebf1662db"}}, "title": "Acute necrotizing encephalopathy with SARS-CoV-2 RNA confirmed in cerebrospinal fluid", "authors": [{"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "F\u00e4llmar", "given": "David", "initials": "D"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Jackmann", "given": "Sven", "initials": "S"}, {"family": "Sk\u00f6ld", "given": "Mattias K", "initials": "MK"}, {"family": "Kadir", "given": "Mohamed", "initials": "M"}, {"family": "Frick", "given": "Jens", "initials": "J"}, {"family": "Lindeberg", "given": "Jonas", "initials": "J"}, {"family": "Olivero-Reinius", "given": "Henrik", "initials": "H"}, {"family": "Ryttlefors", "given": "Mats", "initials": "M"}, {"family": "Cunningham", "given": "Janet L", "initials": "JL"}, {"family": "Wikstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Grabowska", "given": "Anna", "initials": "A"}, {"family": "Bondeson", "given": "K\u00e5re", "initials": "K"}, {"family": "Bergquist", "given": "Jonas", "initials": "J"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Rostami", "given": "Elham", "initials": "E"}], "type": "journal-article", "published": "2020-09-08", "journal": {"title": "Neurology", "issn": "1526-632X", "volume": "95", "issue": "10", "pages": "445-449", "issn-l": "0028-3878"}, "abstract": "Here, we report a case of COVID-19\u2013related acute necrotizing encephalopathy where SARS-CoV-2 RNA was found in CSF 19 days after symptom onset after testing negative twice. Although monocytes and protein levels in CSF were only marginally increased, and our patient never experienced a hyperinflammatory state, her neurologic function deteriorated into coma. MRI of the brain showed pathologic signal symmetrically in central thalami, subinsular regions, medial temporal lobes, and brain stem. Extremely high concentrations of the neuronal injury markers neurofilament light and tau, as well as an astrocytic activation marker, glial fibrillary acidic protein, were measured in CSF. Neuronal rescue proteins and other pathways were elevated in the in-depth proteomics analysis. The patient received IV immunoglobulins and plasma exchange. Her neurologic status improved, and she was extubated 4 weeks after symptom onset. This case report highlights the neurotropism of SARS-CoV-2 in selected patients and emphasizes the importance of repeated lumbar punctures and CSF analyses in patients with suspected COVID-19 and neurologic symptoms.", "doi": "10.1212/wnl.0000000000010250", "pmid": "32586897", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.5061/dryad.xwdbrv1bb", "description": "Proteomic data"}], "notes": [], "created": "2020-11-04T07:45:09.549Z", "modified": "2021-02-26T08:45:48.083Z"}, {"entity": "publication", "iuid": "ac5dc94540534786a6d4b0d8241c1d1c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ac5dc94540534786a6d4b0d8241c1d1c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ac5dc94540534786a6d4b0d8241c1d1c"}}, "title": "Use of biologicals in allergic and type-2 inflammatory diseases during the current COVID-19 pandemic: Position paper of \u00c4rzteverband Deutscher Allergologen (AeDA) A, Deutsche Gesellschaft f\u00fcr Allergologie und Klinische Immunologie (DGAKI)B, Gesellschaft f\u00fcr P\u00e4diatrische Allergologie und Umweltmedizin (GPA)C, \u00d6sterreichische Gesellschaft f\u00fcr Allergologie und Immunologie (\u00d6GAI)D, Luxemburgische Gesellschaft f\u00fcr Allergologie und Immunologie (LGAI)E, \u00d6sterreichische Gesellschaft f\u00fcr Pneumologie (\u00d6GP)F in co-operation with the German, Austrian, and Swiss ARIA groupsG, and the European Academy of Allergy and Clinical Immunology (EAACI)H.", "authors": [{"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Worm", "given": "Margitta", "initials": "M"}, {"family": "Eiwegger", "given": "Thomas", "initials": "T"}, {"family": "Hagemann", "given": "Jan", "initials": "J"}, {"family": "Ollert", "given": "Markus", "initials": "M"}, {"family": "Untersmayr", "given": "Eva", "initials": "E"}, {"family": "Hoffmann-Sommergruber", "given": "Karin", "initials": "K"}, {"family": "Vultaggio", "given": "Alessandra", "initials": "A"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Bavbek", "given": "Sevim", "initials": "S"}, {"family": "Bossios", "given": "Apostolos", "initials": "A"}, {"family": "Casper", "given": "Ingrid", "initials": "I"}, {"family": "Chan", "given": "Susan", "initials": "S"}, {"family": "Chatzipetrou", "given": "Alexia", "initials": "A"}, {"family": "Vogelberg", "given": "Christian", "initials": "C"}, {"family": "Firinu", "given": "Davide", "initials": "D"}, {"family": "Kauppi", "given": "Paula", "initials": "P"}, {"family": "Kolios", "given": "Antonios", "initials": "A"}, {"family": "Kothari", "given": "Akash", "initials": "A"}, {"family": "Matucci", "given": "Andrea", "initials": "A"}, {"family": "Palomares", "given": "Oscar", "initials": "O"}, {"family": "Sz\u00e9pfalusi", "given": "Zsolt", "initials": "Z"}, {"family": "Pohl", "given": "Wolfgang", "initials": "W"}, {"family": "H\u00f6tzenecker", "given": "Wolfram", "initials": "W"}, {"family": "Rosenkranz", "given": "Alexander R", "initials": "AR"}, {"family": "Bergmann", "given": "Karl-Christian", "initials": "KC"}, {"family": "Bieber", "given": "Thomas", "initials": "T"}, {"family": "Buhl", "given": "Roland", "initials": "R"}, {"family": "Buters", "given": "Jeroen", "initials": "J"}, {"family": "Darsow", "given": "Ulf", "initials": "U"}, {"family": "Keil", "given": "Thomas", "initials": "T"}, {"family": "Kleine-Tebbe", "given": "J\u00f6rg", "initials": "J"}, {"family": "Lau", "given": "Susanne", "initials": "S"}, {"family": "Maurer", "given": "Marcus", "initials": "M"}, {"family": "Merk", "given": "Hans", "initials": "H"}, {"family": "M\u00f6sges", "given": "Ralph", "initials": "R"}, {"family": "Saloga", "given": "Joachim", "initials": "J"}, {"family": "Staubach", "given": "Petra", "initials": "P"}, {"family": "Jappe", "given": "Uta", "initials": "U"}, {"family": "Rabe", "given": "Klaus F", "initials": "KF"}, {"family": "Rabe", "given": "Uta", "initials": "U"}, {"family": "Vogelmeier", "given": "Claus", "initials": "C"}, {"family": "Biedermann", "given": "Tilo", "initials": "T"}, {"family": "Jung", "given": "Kirsten", "initials": "K"}, {"family": "Schlenter", "given": "Wolfgang", "initials": "W"}, {"family": "Ring", "given": "Johannes", "initials": "J"}, {"family": "Chaker", "given": "Adam", "initials": "A"}, {"family": "Wehrmann", "given": "Wolfgang", "initials": "W"}, {"family": "Becker", "given": "Sven", "initials": "S"}, {"family": "Freudelsperger", "given": "Laura", "initials": "L"}, {"family": "M\u00fclleneisen", "given": "Norbert", "initials": "N"}, {"family": "Nemat", "given": "Katja", "initials": "K"}, {"family": "Czech", "given": "Wolfgang", "initials": "W"}, {"family": "Wrede", "given": "Holger", "initials": "H"}, {"family": "Brehler", "given": "Randolf", "initials": "R"}, {"family": "Fuchs", "given": "Thomas", "initials": "T"}, {"family": "Tomazic", "given": "Peter-Valentin", "initials": "PV"}, {"family": "Aberer", "given": "Werner", "initials": "W"}, {"family": "Fink-Wagner", "given": "Antje-Henriette", "initials": "AH"}, {"family": "Horak", "given": "Fritz", "initials": "F"}, {"family": "W\u00f6hrl", "given": "Stefan", "initials": "S"}, {"family": "Niederberger-Leppin", "given": "Verena", "initials": "V"}, {"family": "Pali-Sch\u00f6ll", "given": "Isabella", "initials": "I"}, {"family": "Roller-Wirnsberger", "given": "Regina", "initials": "R"}, {"family": "Spranger", "given": "Otto", "initials": "O"}, {"family": "Valenta", "given": "Rudolf", "initials": "R"}, {"family": "Akdis", "given": "M\u00fcbecell", "initials": "M"}, {"family": "Matricardi", "given": "Paolo M", "initials": "PM"}, {"family": "Spertini", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Khaltaev", "given": "Nicolai", "initials": "N"}, {"family": "Michel", "given": "Jean-Pierre", "initials": "JP"}, {"family": "Nicod", "given": "Larent", "initials": "L"}, {"family": "Schmid-Grendelmeier", "given": "Peter", "initials": "P"}, {"family": "Idzko", "given": "Marco", "initials": "M"}, {"family": "Hamelmann", "given": "Eckard", "initials": "E"}, {"family": "Jakob", "given": "Thilo", "initials": "T"}, {"family": "Werfel", "given": "Thomas", "initials": "T"}, {"family": "Wagenmann", "given": "Martin", "initials": "M"}, {"family": "Taube", "given": "Christian", "initials": "C"}, {"family": "Jensen-Jarolim", "given": "Erika", "initials": "E"}, {"family": "Korn", "given": "Stephanie", "initials": "S"}, {"family": "Hentges", "given": "Francois", "initials": "F"}, {"family": "Schwarze", "given": "J\u00fcrgen", "initials": "J"}, {"family": "O Mahony", "given": "Liam", "initials": "L"}, {"family": "Knol", "given": "Edward F", "initials": "EF"}, {"family": "Del Giacco", "given": "Stefano", "initials": "S"}, {"family": "Chivato P\u00e9rez", "given": "Tom\u00e1s", "initials": "T"}, {"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Bedbrook", "given": "Anna", "initials": "A"}, {"family": "Zuberbier", "given": "Torsten", "initials": "T"}, {"family": "Akdis", "given": "Cezmi", "initials": "C"}, {"family": "Jutel", "given": "Marek", "initials": "M"}], "type": "journal article", "published": "2020-09-07", "journal": {"title": "Allergol Select", "issn": "2512-8957", "volume": "4", "issue": null, "pages": "53-68", "issn-l": null}, "abstract": "Since the beginning of the COVID-19 pandemic, the treatment of patients with allergic and atopy-associated diseases has faced major challenges. Recommendations for \"social distancing\" and the fear of patients becoming infected during a visit to a medical facility have led to a drastic decrease in personal doctor-patient contacts. This affects both acute care and treatment of the chronically ill. The immune response after SARS-CoV-2 infection is so far only insufficiently understood and could be altered in a favorable or unfavorable way by therapy with monoclonal antibodies. There is currently no evidence for an increased risk of a severe COVID-19 course in allergic patients. Many patients are under ongoing therapy with biologicals that inhibit type 2 immune responses via various mechanisms. There is uncertainty about possible immunological interactions and potential risks of these biologicals in the case of an infection with SARS-CoV-2.\n\nA selective literature search was carried out in PubMed, Livivo, and the internet to cover the past 10 years (May 2010 - April 2020). Additionally, the current German-language publications were analyzed. Based on these data, the present position paper provides recommendations for the biological treatment of patients with allergic and atopy-associated diseases during the COVID-19 pandemic.\n\nIn order to maintain in-office consultation services, a safe treatment environment must be created that is adapted to the pandemic situation. To date, there is a lack of reliable study data on the care for patients with complex respiratory, atopic, and allergic diseases in times of an imminent infection risk from SARS-CoV-2. Type-2-dominant immune reactions, as they are frequently seen in allergic patients, could influence various phases of COVID-19, e.g., by slowing down the immune reactions. Theoretically, this could have an unfavorable effect in the early phase of a SARS-Cov-2 infection, but also a positive effect during a cytokine storm in the later phase of severe courses. However, since there is currently no evidence for this, all data from patients treated with a biological directed against type 2 immune reactions who develop COVID-19 should be collected in registries, and their disease courses documented in order to be able to provide experience-based instructions in the future.\n\nThe use of biologicals for the treatment of bronchial asthma, atopic dermatitis, chronic rhinosinusitis with nasal polyps, and spontaneous urticaria should be continued as usual in patients without suspected infection or proven SARS-CoV-2 infection. If available, it is recommended to prefer a formulation for self-application and to offer telemedical monitoring. Treatment should aim at the best possible control of difficult-to-control allergic and atopic diseases using adequate rescue and add-on therapy and should avoid the need for systemic glucocorticosteroids. If SARS-CoV-2 infection is proven or reasonably suspected, the therapy should be determined by weighing the benefits and risks individually for the patient in question, and the patient should be involved in the decision-making. It should be kept in mind that the potential effects of biologicals on the immune response in COVID-19 are currently not known. Telemedical offers are particularly desirable for the acute consultation needs of suitable patients.", "doi": "10.5414/ALX02166E", "pmid": "32915172", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7480069"}], "notes": [], "created": "2020-12-03T15:49:30.607Z", "modified": "2020-12-03T15:49:30.629Z"}, {"entity": "publication", "iuid": "38380a4ee3434dedb9da6814ea406069", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/38380a4ee3434dedb9da6814ea406069.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/38380a4ee3434dedb9da6814ea406069"}}, "title": "Characteristics and outcomes of patients with COVID-19 admitted to ICU in a tertiary hospital in Stockholm, Sweden.", "authors": [{"family": "Larsson", "given": "Emma", "initials": "E"}, {"family": "Brattstr\u00f6m", "given": "Olof", "initials": "O"}, {"family": "Agvald-\u00d6hman", "given": "Christina", "initials": "C"}, {"family": "Grip", "given": "Jonathan", "initials": "J"}, {"family": "Campoccia Jalde", "given": "Francesca", "initials": "F"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Naucl\u00e9r", "given": "Pontus", "initials": "P"}, {"family": "Oldner", "given": "Anders", "initials": "A"}, {"family": "Konrad", "given": "David", "initials": "D"}, {"family": "Persson", "given": "Bj\u00f6rn P", "initials": "BP"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "M\u00e5rtensson", "given": "Johan", "initials": "J"}, {"family": "Karolinska Intensive Care COVID-19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-09-06", "journal": {"title": "Acta Anaesthesiol Scand", "issn": "1399-6576", "issn-l": "0001-5172", "volume": "65", "issue": "1", "pages": "76-81"}, "abstract": "Information on characteristics and outcomes of intensive care unit (ICU) patients with COVID-19 remains limited. We examined characteristics, clinical course and early outcomes of patients with COVID-19 admitted to ICU.\r\n\r\nWe included all 260 patients with COVID-19 admitted to nine ICUs at the Karolinska University Hospital (Stockholm, Sweden) between 9 March and 20 April 2020. Primary outcome was in-hospital mortality among patients with definite outcomes (discharged from ICU or death), as of 30 April 2020 (study end point). Secondary outcomes included ICU length of stay, the proportion of patients receiving mechanical ventilation and renal replacement therapy, and hospital discharge destination.\r\n\r\nOf 260 ICU patients with COVID-19, 208 (80.0%) were men, the median age was 59 (IQR 51-65) years, 154 (59.2%) had at least one comorbidity, and the median duration of symptoms preceding ICU admission was 11 (IQR 8-14) days. Sixty-two (23.8%) patients remained in ICU at study end point. Among the 198 patients with definite outcomes, ICU length of stay was 12 (IQR, 6-18) days, 163 (82.3%) received mechanical ventilation, 28 (14.1%) received renal replacement therapy, 60 (30.3%) died, 62 (31.3%) were discharged home, 47 (23.7%) were discharged to ward, and 29 (14.6%) were discharged to another health care facility. On multivariable logistic regression analysis, older age and admission from the emergency department was associated with higher mortality.\r\n\r\nThis study presents detailed data on clinical characteristics and early outcomes of consecutive patients with COVID-19 admitted to ICU in a large tertiary hospital in Sweden.", "doi": "10.1111/aas.13694", "pmid": "32892337", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Available on request", "description": null}], "notes": [], "created": "2020-10-30T11:51:51.497Z", "modified": "2021-02-26T08:45:48.054Z"}, {"entity": "publication", "iuid": "0844d9bb4cf3455ca7975029df6d3bc0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0844d9bb4cf3455ca7975029df6d3bc0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0844d9bb4cf3455ca7975029df6d3bc0"}}, "title": "A Parsimonious Description and Cross-Country Analysis of COVID-19 Epidemic Curves.", "authors": [{"family": "Rypdal", "given": "Kristoffer", "initials": "K"}, {"family": "Rypdal", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2020-09-06", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "18", "pages": null}, "abstract": "In a given country, the cumulative death toll of the first wave of the COVID-19 epidemic follows a sigmoid curve as a function of time. In most cases, the curve is well described by the Gompertz function, which is characterized by two essential parameters, the initial growth rate and the decay rate as the first epidemic wave subsides. These parameters are determined by socioeconomic factors and the countermeasures to halt the epidemic. The Gompertz model implies that the total death toll depends exponentially, and hence very sensitively, on the ratio between these rates. The remarkably different epidemic curves for the first epidemic wave in Sweden and Norway and many other countries are classified and discussed in this framework, and their usefulness for the planning of mitigation strategies is discussed.", "doi": "10.3390/ijerph17186487", "pmid": "32899971", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "ijerph17186487"}, {"db": "pmc", "key": "PMC7559235"}], "notes": [], "created": "2020-12-06T07:16:46.279Z", "modified": "2022-11-10T06:40:21.982Z"}, {"entity": "publication", "iuid": "ed49959fb39d452fadbb4ffa061eb01e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed49959fb39d452fadbb4ffa061eb01e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed49959fb39d452fadbb4ffa061eb01e"}}, "title": "Virions and respiratory droplets in air: Diffusion, drift, and contact with the epithelium.", "authors": [{"family": "Zhdanov", "given": "Vladimir P", "initials": "VP"}, {"family": "Kasemo", "given": "Bengt", "initials": "B"}], "type": "journal article", "published": "2020-09-05", "journal": {"title": "Biosystems", "issn": "1872-8324", "volume": "198", "issue": null, "pages": "104241", "issn-l": null}, "abstract": "Some infections, including e.g. influenza and currently active COVID 19, may be transmitted via air during sneezing, coughing, and talking. This pathway occurs via diffusion and gravity-induced drift of single virions and respiratory droplets consisting primarily of water, including small fraction of nonvolatile matter, and containing virions. These processes are accompanied by water evaporation resulting in reduction of the droplet size. The manifold of information concerning these steps is presented in textbooks and articles not related to virology and the focus is there frequently on biologically irrelevant conditions and/or droplet sizes. In this brief review, we systematically describe the behavior of virions and virion-carrying droplets in air with emphasis on various regimes of diffusion, drift, and evaporation, and estimate the rates of all these steps under virologically relevant conditions. In addition, we discuss the kinetic aspects of the first steps of infection after attachment of virions or virion-carrying droplets to the epithelium, i.e., virion diffusion in the mucus and periciliary layers, penetration into the cells, and the early stage of replication. The presentation is oriented to virologists who are interested in the corresponding physics and to physicists who are interested in application of the physics to virology.", "doi": "10.1016/j.biosystems.2020.104241", "pmid": "32896576", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0303-2647(20)30129-5"}], "notes": [], "created": "2020-11-30T08:36:32.889Z", "modified": "2020-11-30T08:36:32.913Z"}, {"entity": "publication", "iuid": "4955f61547fa4675b79c608a93485b66", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4955f61547fa4675b79c608a93485b66.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4955f61547fa4675b79c608a93485b66"}}, "title": "Sarcoma European and Latin American Network (SELNET) Recommendations on Prioritization in Sarcoma Care During the COVID-19 Pandemic.", "authors": [{"family": "Martin-Broto", "given": "Javier", "initials": "J"}, {"family": "Hindi", "given": "Nadia", "initials": "N"}, {"family": "Aguiar", "given": "Samuel", "initials": "S"}, {"family": "Badilla-Gonz\u00e1lez", "given": "Ronald", "initials": "R"}, {"family": "Castro-Oliden", "given": "Victor", "initials": "V"}, {"family": "Chac\u00f3n", "given": "Matias", "initials": "M"}, {"family": "Correa-Generoso", "given": "Raquel", "initials": "R"}, {"family": "de \u00c1lava", "given": "Enrique", "initials": "E"}, {"family": "Donati", "given": "Davide Mar\u00eda", "initials": "DM"}, {"family": "Eriksson", "given": "Mikael", "initials": "M"}, {"family": "Falla-Jimenez", "given": "Martin", "initials": "M"}, {"family": "German", "given": "Gisela", "initials": "G"}, {"family": "Gobo Silva", "given": "Maria Leticia", "initials": "ML"}, {"family": "Gouin", "given": "Francois", "initials": "F"}, {"family": "Gronchi", "given": "Alessandro", "initials": "A"}, {"family": "Haro-Varas", "given": "Juan Carlos", "initials": "JC"}, {"family": "Jim\u00e9nez-Brenes", "given": "Natalia", "initials": "N"}, {"family": "Kasper", "given": "Bernd", "initials": "B"}, {"family": "Lopes de Mello", "given": "Celso Abdon", "initials": "CA"}, {"family": "Maki", "given": "Robert", "initials": "R"}, {"family": "Mart\u00ednez-Delgado", "given": "Paula", "initials": "P"}, {"family": "Mart\u00ednez-Said", "given": "Hector", "initials": "H"}, {"family": "Martinez-Tlahuel", "given": "Jorge Luis", "initials": "JL"}, {"family": "Morales-P\u00e9rez", "given": "Jose Manuel", "initials": "JM"}, {"family": "Mu\u00f1oz-Casares", "given": "Francisco Cristobal", "initials": "FC"}, {"family": "Nakagawa", "given": "Suely A", "initials": "SA"}, {"family": "Ortiz-Cruz", "given": "Eduardo Jose", "initials": "EJ"}, {"family": "Palmerini", "given": "Emanuela", "initials": "E"}, {"family": "Patel", "given": "Shreyaskumar", "initials": "S"}, {"family": "Moura", "given": "David S", "initials": "DS"}, {"family": "Stacchiotti", "given": "Silvia", "initials": "S"}, {"family": "Sunyach", "given": "Marie Pierre", "initials": "MP"}, {"family": "Valverde", "given": "Claudia M", "initials": "CM"}, {"family": "Waisberg", "given": "Federico", "initials": "F"}, {"family": "Blay", "given": "Jean-Yves", "initials": "JY"}], "type": "journal article", "published": "2020-09-05", "journal": {"title": "Oncologist", "issn": "1549-490X", "volume": null, "issue": null, "issn-l": null}, "abstract": "The COVID-19 outbreak has resulted in collision between patients infected with SARS-CoV-2 and those with cancer on different fronts. Patients with cancer have been impacted by deferral, modification, and even cessation of therapy. Adaptive measures to minimize hospital exposure, following the precautionary principle, have been proposed for cancer care during COVID-19 era. We present here a consensus on prioritizing recommendations across the continuum of sarcoma patient care.\n\nA total of 125 recommendations were proposed in soft-tissue, bone, and visceral sarcoma care. Recommendations were assigned as higher or lower priority if they cannot or can be postponed at least 2-3 months, respectively. The consensus level for each recommendation was classified as \"strongly recommended\" (SR) if more than 90% of experts agreed, \"recommended\" (R) if 75%-90% of experts agreed and \"no consensus\" (NC) if fewer than 75% agreed. Sarcoma experts from 11 countries within the Sarcoma European-Latin American Network (SELNET) consortium participated, including countries in the Americas and Europe. The European Society for Medical Oncology-Magnitude of clinical benefit scale was applied to systemic-treatment recommendations to support prioritization.\n\nThere were 80 SRs, 35 Rs, and 10 NCs among the 125 recommendations issued and completed by 31 multidisciplinary sarcoma experts. The consensus was higher among the 75 higher-priority recommendations (85%, 12%, and 3% for SR, R, and NC, respectively) than in the 50 lower-priority recommendations (32%, 52%, and 16% for SR, R, and NC, respectively).\n\nThe consensus on 115 of 125 recommendations indicates a high-level of convergence among experts. The SELNET consensus provides a tool for sarcoma multidisciplinary treatment committees during the COVID-19 outbreak.\n\nThe Sarcoma European-Latin American Network (SELNET) consensus on sarcoma prioritization care during the COVID-19 era issued 125 pragmatical recommendations distributed as higher or lower priority to protect critical decisions on sarcoma care during the COVID-19 pandemic. A multidisciplinary team from 11 countries reached consensus on 115 recommendations. The consensus was lower among lower-priority recommendations, which shows reticence to postpone actions even in indolent tumors. The European Society for Medical Oncology-Magnitude of Clinical Benefit scale was applied as support for prioritizing systemic treatment. Consensus on 115 of 125 recommendations indicates a high level of convergence among experts. The SELNET consensus provides a practice tool for guidance in the decisions of sarcoma multidisciplinary treatment committees during the COVID-19 outbreak.", "doi": "10.1634/theoncologist.2020-0516", "pmid": "32888360", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7543334"}], "notes": [], "created": "2020-12-06T07:27:04.756Z", "modified": "2020-12-06T07:27:04.766Z"}, {"entity": "publication", "iuid": "f35daacf9246431abd1b5eac85d3010c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f35daacf9246431abd1b5eac85d3010c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f35daacf9246431abd1b5eac85d3010c"}}, "title": "Treatment with angiotensin II in COVID-19 patients may not be beneficial.", "authors": [{"family": "Rysz", "given": "Susanne", "initials": "S"}, {"family": "Jalde", "given": "Francesca Campoccia", "initials": "FC"}, {"family": "Oldner", "given": "Anders", "initials": "A"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Lundberg", "given": "Johan", "initials": "J"}, {"family": "Fagerlund", "given": "Malin Jonsson", "initials": "MJ"}], "type": "letter", "published": "2020-09-04", "journal": {"title": "Crit Care", "issn": "1466-609X", "volume": "24", "issue": "1", "pages": "546", "issn-l": "1364-8535"}, "abstract": null, "doi": "10.1186/s13054-020-03233-6", "pmid": "32887650", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-020-03233-6"}, {"db": "pmc", "key": "PMC7472408"}], "notes": [], "created": "2020-12-06T07:27:42.373Z", "modified": "2020-12-06T07:27:42.386Z"}, {"entity": "publication", "iuid": "3aa6e6a8aff044aebc36dc62bc8c6b52", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3aa6e6a8aff044aebc36dc62bc8c6b52.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3aa6e6a8aff044aebc36dc62bc8c6b52"}}, "title": "Complicated COVID-19 in pregnancy: a case report with severe liver and coagulation dysfunction promptly improved by delivery.", "authors": [{"family": "Ronnje", "given": "Louise", "initials": "L"}, {"family": "L\u00e4nsberg", "given": "John-Kalle", "initials": "JK"}, {"family": "Vikhareva", "given": "Olga", "initials": "O"}, {"family": "Hansson", "given": "Stefan R", "initials": "SR"}, {"family": "Herbst", "given": "Andreas", "initials": "A"}, {"family": "Zaigham", "given": "Mehreen", "initials": "M"}], "type": "journal article", "published": "2020-09-04", "journal": {"title": "BMC Pregnancy Childbirth", "issn": "1471-2393", "volume": "20", "issue": "1", "pages": "511", "issn-l": null}, "abstract": "It has been proposed that pregnant women and their fetuses may be particularly at risk for poor outcomes due to the coronavirus (COVID-19) pandemic. From the few case series that are available in the literature, women with high risk pregnancies have been associated with higher morbidity. It has been suggested that pregnancy induced immune responses and cardio-vascular changes can exaggerate the course of the COVID-19 infection.\n\nA 26-year old Somalian woman (G2P1) presented with a nine-day history of shortness of breath, dry cough, myalgia, nausea, abdominal pain and fever. A nasopharyngeal swab returned positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Her condition rapidly worsened leading to severe liver and coagulation impairment. An emergency Caesarean section was performed at gestational week 32 + 6 after which the patient made a rapid recovery. Severe COVID-19 promptly improved by the termination of the pregnancy or atypical HELLP (Hemolysis, Elevated Liver Enzymes and Low Platelet Count) exacerbated by concomitant COVID-19 infection could not be ruled out. There was no evidence of vertical transmission.\n\nThis case adds to the growing body of evidence which raises concerns about the possible negative maternal outcomes of COVID-19 infection during pregnancy and advocates for pregnant women to be recognized as a vulnerable group during the current pandemic.", "doi": "10.1186/s12884-020-03172-8", "pmid": "32887569", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12884-020-03172-8"}, {"db": "pmc", "key": "PMC7472409"}], "notes": [], "created": "2020-12-06T07:29:06.065Z", "modified": "2021-02-26T08:45:48.066Z"}, {"entity": "publication", "iuid": "6de1c1add6e94b78b6239f786907ce70", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6de1c1add6e94b78b6239f786907ce70.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6de1c1add6e94b78b6239f786907ce70"}}, "title": "Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline (updated version).", "authors": [{"family": "Jin", "given": "Ying-Hui", "initials": "YH"}, {"family": "Zhan", "given": "Qing-Yuan", "initials": "QY"}, {"family": "Peng", "given": "Zhi-Yong", "initials": "ZY"}, {"family": "Ren", "given": "Xue-Qun", "initials": "XQ"}, {"family": "Yin", "given": "Xun-Tao", "initials": "XT"}, {"family": "Cai", "given": "Lin", "initials": "L"}, {"family": "Yuan", "given": "Yu-Feng", "initials": "YF"}, {"family": "Yue", "given": "Ji-Rong", "initials": "JR"}, {"family": "Zhang", "given": "Xiao-Chun", "initials": "XC"}, {"family": "Yang", "given": "Qi-Wen", "initials": "QW"}, {"family": "Ji", "given": "Jianguang", "initials": "J"}, {"family": "Xia", "given": "Jian", "initials": "J"}, {"family": "Li", "given": "Yi-Rong", "initials": "YR"}, {"family": "Zhou", "given": "Fu-Xiang", "initials": "FX"}, {"family": "Gao", "given": "Ya-Dong", "initials": "YD"}, {"family": "Yu", "given": "Zhui", "initials": "Z"}, {"family": "Xu", "given": "Feng", "initials": "F"}, {"family": "Tu", "given": "Ming-Li", "initials": "ML"}, {"family": "Tan", "given": "Li-Ming", "initials": "LM"}, {"family": "Yang", "given": "Min", "initials": "M"}, {"family": "Chen", "given": "Fang", "initials": "F"}, {"family": "Zhang", "given": "Xiao-Ju", "initials": "XJ"}, {"family": "Zeng", "given": "Mei", "initials": "M"}, {"family": "Zhu", "given": "Yu", "initials": "Y"}, {"family": "Liu", "given": "Xin-Can", "initials": "XC"}, {"family": "Yang", "given": "Jian", "initials": "J"}, {"family": "Zhao", "given": "Dong-Chi", "initials": "DC"}, {"family": "Ding", "given": "Yu-Feng", "initials": "YF"}, {"family": "Hou", "given": "Ning", "initials": "N"}, {"family": "Wang", "given": "Fu-Bing", "initials": "FB"}, {"family": "Chen", "given": "Hao", "initials": "H"}, {"family": "Zhang", "given": "Yong-Gang", "initials": "YG"}, {"family": "Li", "given": "Wei", "initials": "W"}, {"family": "Chen", "given": "Wen", "initials": "W"}, {"family": "Shi", "given": "Yue-Xian", "initials": "YX"}, {"family": "Yang", "given": "Xiu-Zhi", "initials": "XZ"}, {"family": "Wang", "given": "Xue-Jun", "initials": "XJ"}, {"family": "Zhong", "given": "Yan-Jun", "initials": "YJ"}, {"family": "Zhao", "given": "Ming-Juan", "initials": "MJ"}, {"family": "Li", "given": "Bing-Hui", "initials": "BH"}, {"family": "Ma", "given": "Lin-Lu", "initials": "LL"}, {"family": "Zi", "given": "Hao", "initials": "H"}, {"family": "Wang", "given": "Na", "initials": "N"}, {"family": "Wang", "given": "Yun-Yun", "initials": "YY"}, {"family": "Yu", "given": "Shao-Fu", "initials": "SF"}, {"family": "Li", "given": "Lu-Yao", "initials": "LY"}, {"family": "Huang", "given": "Qiao", "initials": "Q"}, {"family": "Weng", "given": "Hong", "initials": "H"}, {"family": "Ren", "given": "Xiang-Ying", "initials": "XY"}, {"family": "Luo", "given": "Li-Sha", "initials": "LS"}, {"family": "Fan", "given": "Man-Ru", "initials": "MR"}, {"family": "Huang", "given": "Di", "initials": "D"}, {"family": "Xue", "given": "Hong-Yang", "initials": "HY"}, {"family": "Yu", "given": "Lin-Xin", "initials": "LX"}, {"family": "Gao", "given": "Jin-Ping", "initials": "JP"}, {"family": "Deng", "given": "Tong", "initials": "T"}, {"family": "Zeng", "given": "Xian-Tao", "initials": "XT", "orcid": "0000-0003-1262-725X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a6ac51af3f0b4269b2d7ad82fd726e09.json"}}, {"family": "Li", "given": "Hong-Jun", "initials": "HJ"}, {"family": "Cheng", "given": "Zhen-Shun", "initials": "ZS"}, {"family": "Yao", "given": "Xiaomei", "initials": "X"}, {"family": "Wang", "given": "Xing-Huan", "initials": "XH"}, {"family": "Evidence-Based Medicine Chapter of China International Exchange and Promotive Association for Medical and Health Care (CPAM)", "given": "", "initials": ""}, {"family": "Chinese Research Hospital Association (CRHA)", "given": "", "initials": ""}], "type": "journal article", "published": "2020-09-04", "journal": {"title": "Mil Med Res", "issn": "2054-9369", "volume": "7", "issue": "1", "pages": "41", "issn-l": null}, "abstract": "The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, coronavirus disease 2019 (COVID-19), affecting more than seventeen million people around the world. Diagnosis and treatment guidelines for clinicians caring for patients are needed. In the early stage, we have issued \"A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)\"; now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline. We formed a working group of clinical experts and methodologists. The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas: chemoprophylaxis, diagnosis, treatments, and discharge management. We searched the literature for direct evidence on the management of COVID-19, and assessed its certainty generated recommendations using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Recommendations were either strong or weak, or in the form of ungraded consensus-based statement. Finally, we issued 34 statements. Among them, 6 were strong recommendations for, 14 were weak recommendations for, 3 were weak recommendations against and 11 were ungraded consensus-based statement. They covered topics of chemoprophylaxis (including agents and Traditional Chinese Medicine (TCM) agents), diagnosis (including clinical manifestations, reverse transcription-polymerase chain reaction (RT-PCR), respiratory tract specimens, IgM and IgG antibody tests, chest computed tomography, chest x-ray, and CT features of asymptomatic infections), treatments (including lopinavir-ritonavir, umifenovir, favipiravir, interferon, remdesivir, combination of antiviral drugs, hydroxychloroquine/chloroquine, interleukin-6 inhibitors, interleukin-1 inhibitors, glucocorticoid, qingfei paidu decoction, lianhua qingwen granules/capsules, convalescent plasma, lung transplantation, invasive or noninvasive ventilation, and extracorporeal membrane oxygenation (ECMO)), and discharge management (including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge). We also created two figures of these recommendations for the implementation purpose. We hope these recommendations can help support healthcare workers caring for COVID-19 patients.", "doi": "10.1186/s40779-020-00270-8", "pmid": "32887670", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7472403"}, {"db": "pii", "key": "10.1186/s40779-020-00270-8"}], "notes": [], "created": "2020-12-06T07:27:19.354Z", "modified": "2023-06-19T15:37:30.085Z"}, {"entity": "publication", "iuid": "c405a953cb044229a5b18e6351e3e1fe", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c405a953cb044229a5b18e6351e3e1fe.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c405a953cb044229a5b18e6351e3e1fe"}}, "title": "An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.", "authors": [{"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Vidakovics Perez", "given": "Laura", "initials": "L"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Das", "given": "Hrishikesh", "initials": "H"}, {"family": "Schulte", "given": "Tim", "initials": "T"}, {"family": "Moliner-Morro", "given": "Ainhoa", "initials": "A"}, {"family": "Corcoran", "given": "Martin", "initials": "M"}, {"family": "Achour", "given": "Adnane", "initials": "A"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "H\u00e4llberg", "given": "B Martin", "initials": "BM"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "McInerney", "given": "Gerald M", "initials": "GM"}], "type": "journal article", "published": "2020-09-04", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "11", "issue": "1", "pages": "4420"}, "abstract": "SARS-CoV-2 enters host cells through an interaction between the spike glycoprotein and the angiotensin converting enzyme 2 (ACE2) receptor. Directly preventing this interaction presents an attractive possibility for suppressing SARS-CoV-2 replication. Here, we report the isolation and characterization of an alpaca-derived single domain antibody fragment, Ty1, that specifically targets the receptor binding domain (RBD) of the SARS-CoV-2 spike, directly preventing ACE2 engagement. Ty1 binds the RBD with high affinity, occluding ACE2. A cryo-electron microscopy structure of the bound complex at 2.9 \u00c5 resolution reveals that Ty1 binds to an epitope on the RBD accessible in both the 'up' and 'down' conformations, sterically hindering RBD-ACE2 binding. While fusion to an Fc domain renders Ty1 extremely potent, Ty1 neutralizes SARS-CoV-2 spike pseudovirus as a 12.8 kDa nanobody, which can be expressed in high quantities in bacteria, presenting opportunities for manufacturing at scale. Ty1 is therefore an excellent candidate as an intervention against COVID-19.", "doi": "10.1038/s41467-020-18174-5", "pmid": "32887876", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: H2020": null, "Category: Biochemistry": null}, "xrefs": [{"db": "GENBANK", "key": "MT784731", "description": "Sequence of Ty1"}, {"db": "URL", "key": "https://github.com/derpaule/Ty1_octet_itc", "description": "ITC data"}, {"db": "URL", "key": "https://github.com/MurrellGroup/Ty1", "description": "Jupyter notebooks to reproduce the NGS data processing"}, {"db": "URL", "key": "https://www.ebi.ac.uk/pdbe/entry/emdb/EMD-11526", "description": "EMDB EMD-11526: Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing nanobodies"}, {"db": "PDB", "key": "6ZXN", "description": "Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing nanobodies (Ty1)"}, {"db": "BioProject", "key": "PRJNA638614", "description": "Next generation sequencing data"}], "notes": [], "created": "2020-10-28T09:09:58.686Z", "modified": "2021-02-26T08:45:03.240Z"}, {"entity": "publication", "iuid": "ed6938f129a644cdb6b4c4b232d3dbd8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ed6938f129a644cdb6b4c4b232d3dbd8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ed6938f129a644cdb6b4c4b232d3dbd8"}}, "title": "Outcomes of COVID-19 in patients with CLL: a multicenter international experience.", "authors": [{"family": "Mato", "given": "Anthony R", "initials": "AR"}, {"family": "Roeker", "given": "Lindsey E", "initials": "LE"}, {"family": "Lamanna", "given": "Nicole", "initials": "N"}, {"family": "Allan", "given": "John N", "initials": "JN"}, {"family": "Leslie", "given": "Lori", "initials": "L"}, {"family": "Pagel", "given": "John M", "initials": "JM"}, {"family": "Patel", "given": "Krish", "initials": "K"}, {"family": "Osterborg", "given": "Anders", "initials": "A"}, {"family": "Wojenski", "given": "Daniel", "initials": "D"}, {"family": "Kamdar", "given": "Manali", "initials": "M"}, {"family": "Huntington", "given": "Scott F", "initials": "SF"}, {"family": "Davids", "given": "Matthew S", "initials": "MS"}, {"family": "Brown", "given": "Jennifer R", "initials": "JR"}, {"family": "Antic", "given": "Darko", "initials": "D"}, {"family": "Jacobs", "given": "Ryan", "initials": "R"}, {"family": "Ahn", "given": "Inhye E", "initials": "IE"}, {"family": "Pu", "given": "Jeffrey", "initials": "J"}, {"family": "Isaac", "given": "Krista M", "initials": "KM"}, {"family": "Barr", "given": "Paul M", "initials": "PM"}, {"family": "Ujjani", "given": "Chaitra S", "initials": "CS"}, {"family": "Geyer", "given": "Mark B", "initials": "MB"}, {"family": "Berman", "given": "Ellin", "initials": "E"}, {"family": "Zelenetz", "given": "Andrew D", "initials": "AD"}, {"family": "Malakhov", "given": "Nikita", "initials": "N"}, {"family": "Furman", "given": "Richard R", "initials": "RR"}, {"family": "Koropsak", "given": "Michael", "initials": "M"}, {"family": "Bailey", "given": "Neil", "initials": "N"}, {"family": "Hanson", "given": "Lotta", "initials": "L"}, {"family": "Perini", "given": "Guilherme F", "initials": "GF"}, {"family": "Ma", "given": "Shuo", "initials": "S"}, {"family": "Ryan", "given": "Christine E", "initials": "CE"}, {"family": "Wiestner", "given": "Adrian", "initials": "A"}, {"family": "Portell", "given": "Craig A", "initials": "CA"}, {"family": "Shadman", "given": "Mazyar", "initials": "M"}, {"family": "Chong", "given": "Elise A", "initials": "EA"}, {"family": "Brander", "given": "Danielle M", "initials": "DM"}, {"family": "Sundaram", "given": "Suchitra", "initials": "S"}, {"family": "Seddon", "given": "Amanda N", "initials": "AN"}, {"family": "Seymour", "given": "Erlene", "initials": "E"}, {"family": "Patel", "given": "Meera", "initials": "M"}, {"family": "Martinez-Calle", "given": "Nicolas", "initials": "N"}, {"family": "Munir", "given": "Talha", "initials": "T"}, {"family": "Walewska", "given": "Renata", "initials": "R"}, {"family": "Broom", "given": "Angus", "initials": "A"}, {"family": "Walter", "given": "Harriet", "initials": "H"}, {"family": "El-Sharkawi", "given": "Dima", "initials": "D"}, {"family": "Parry", "given": "Helen", "initials": "H"}, {"family": "Wilson", "given": "Matthew R", "initials": "MR"}, {"family": "Patten", "given": "Piers E M", "initials": "PEM"}, {"family": "Hern\u00e1ndez-Rivas", "given": "Jos\u00e9-\u00c1ngel", "initials": "J\u00c1"}, {"family": "Miras", "given": "Fatima", "initials": "F"}, {"family": "Fern\u00e1ndez Escalada", "given": "Noemi", "initials": "N"}, {"family": "Ghione", "given": "Paola", "initials": "P"}, {"family": "Nabhan", "given": "Chadi", "initials": "C"}, {"family": "Lebowitz", "given": "Sonia", "initials": "S"}, {"family": "Bhavsar", "given": "Erica", "initials": "E"}, {"family": "L\u00f3pez-Jim\u00e9nez", "given": "Javier", "initials": "J"}, {"family": "Naya", "given": "Daniel", "initials": "D"}, {"family": "Garcia-Marco", "given": "Jose Antonio", "initials": "JA"}, {"family": "Sk\u00e5nland", "given": "Sigrid S", "initials": "SS"}, {"family": "Cordoba", "given": "Raul", "initials": "R"}, {"family": "Eyre", "given": "Toby A", "initials": "TA"}], "type": "clinical trial", "published": "2020-09-03", "journal": {"title": "Blood", "issn": "1528-0020", "volume": "136", "issue": "10", "pages": "1134-1143", "issn-l": null}, "abstract": "Given advanced age, comorbidities, and immune dysfunction, chronic lymphocytic leukemia (CLL) patients may be at particularly high risk of infection and poor outcomes related to coronavirus disease 2019 (COVID-19). Robust analysis of outcomes for CLL patients, particularly examining effects of baseline characteristics and CLL-directed therapy, is critical to optimally manage CLL patients through this evolving pandemic. CLL patients diagnosed with symptomatic COVID-19 across 43 international centers (n = 198) were included. Hospital admission occurred in 90%. Median age at COVID-19 diagnosis was 70.5 years. Median Cumulative Illness Rating Scale score was 8 (range, 4-32). Thirty-nine percent were treatment naive (\"watch and wait\"), while 61% had received \u22651 CLL-directed therapy (median, 2; range, 1-8). Ninety patients (45%) were receiving active CLL therapy at COVID-19 diagnosis, most commonly Bruton tyrosine kinase inhibitors (BTKi's; n = 68/90 [76%]). At a median follow-up of 16 days, the overall case fatality rate was 33%, though 25% remain admitted. Watch-and-wait and treated cohorts had similar rates of admission (89% vs 90%), intensive care unit admission (35% vs 36%), intubation (33% vs 25%), and mortality (37% vs 32%). CLL-directed treatment with BTKi's at COVID-19 diagnosis did not impact survival (case fatality rate, 34% vs 35%), though the BTKi was held during the COVID-19 course for most patients. These data suggest that the subgroup of CLL patients admitted with COVID-19, regardless of disease phase or treatment status, are at high risk of death. Future epidemiologic studies are needed to assess severe acute respiratory syndrome coronavirus 2 infection risk, these data should be validated independently, and randomized studies of BTKi's in COVID-19 are needed to provide definitive evidence of benefit.", "doi": "10.1182/blood.2020006965", "pmid": "32688395", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "461426"}, {"db": "pmc", "key": "PMC7472711"}], "notes": [], "created": "2020-12-07T16:30:16.839Z", "modified": "2021-02-26T08:45:03.331Z"}, {"entity": "publication", "iuid": "7b945315d0934beba3a131f7efdb347c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7b945315d0934beba3a131f7efdb347c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7b945315d0934beba3a131f7efdb347c"}}, "title": "Inadequate prophylactic effect of low-molecular weight heparin in critically ill COVID-19 patients.", "authors": [{"family": "Stattin", "given": "K", "initials": "K"}, {"family": "Lipcsey", "given": "M", "initials": "M"}, {"family": "Andersson", "given": "H", "initials": "H"}, {"family": "Pont\u00e9n", "given": "E", "initials": "E"}, {"family": "B\u00fclow Anderberg", "given": "S", "initials": "S"}, {"family": "Gradin", "given": "A", "initials": "A"}, {"family": "Larsson", "given": "A", "initials": "A"}, {"family": "Lubenow", "given": "N", "initials": "N"}, {"family": "von Seth", "given": "M", "initials": "M"}, {"family": "Rubertsson", "given": "S", "initials": "S"}, {"family": "Hultstr\u00f6m", "given": "M", "initials": "M"}, {"family": "Frithiof", "given": "R", "initials": "R"}], "type": "journal article", "published": "2020-09-03", "journal": {"title": "J Crit Care", "issn": "1557-8615", "issn-l": "0883-9441", "volume": "60", "issue": null, "pages": "249-252"}, "abstract": "The aim of this study was to investigate potential markers of coagulopathy and the effects of thromboprophylaxis with low-molecular-weight heparin (LMWH) on thromboelastography (TEG) and anti-factor Xa in critically ill COVID-19 patients.\r\n\r\nWe conducted a prospective study in 31 consecutive adult intensive care unit (ICU) patients. TEG with and without heparinase and anti-factor Xa analysis were performed. Standard thromboprophylaxis was given with dalteparin (75-100 IU/kg subcutaneously).\r\n\r\nFive patients (16%) had symptomatic thromboembolic events. All patients had a maximum amplitude (MA) > 65 mm and 13 (42%) had MA > 72 mm at some point during ICU stay. Anti-factor Xa activity were below the target range in 23% of the patients and above target range in 46% of patients. There was no significant correlation between dalteparin dose and anti-factor Xa activity.\r\n\r\nPatients with COVID-19 have hypercoagulability with high MA on TEG. The effect of LMWH on thromboembolic disease, anti-factor Xa activity and TEG was variable and could not be reliably predicted. This indicates that standard prophylactic doses of LMWH may be insufficient. Monitoring coagulation and the LMWH effect is important in patients with COVID-19 but interpreting the results in relation to risk of thromboembolic disease poses difficulties.", "doi": "10.1016/j.jcrc.2020.08.026", "pmid": "32920503", "labels": {"Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-04T15:28:40.388Z", "modified": "2021-02-26T08:45:48.368Z"}, {"entity": "publication", "iuid": "e9ec5321a98b4d0a8c212629069c6a8a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e9ec5321a98b4d0a8c212629069c6a8a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e9ec5321a98b4d0a8c212629069c6a8a"}}, "title": "Factors contributing to healthcare professional burnout during the COVID-19 pandemic: A rapid turnaround global survey", "authors": [{"family": "Morgantini", "given": "Luca A", "initials": "LA"}, {"family": "Naha", "given": "Ushasi", "initials": "U"}, {"family": "Wang", "given": "Heng", "initials": "H"}, {"family": "Francavilla", "given": "Simone", "initials": "S"}, {"family": "Acar", "given": "\u00d6mer", "initials": "\u00d6"}, {"family": "Flores", "given": "Jose M", "initials": "JM"}, {"family": "Crivellaro", "given": "Simone", "initials": "S"}, {"family": "Moreira", "given": "Daniel", "initials": "D"}, {"family": "Abern", "given": "Michael", "initials": "M"}, {"family": "Eklund", "given": "Martin", "initials": "M"}, {"family": "Vigneswaran", "given": "Hari T", "initials": "HT"}, {"family": "Weine", "given": "Stevan M", "initials": "SM"}], "type": "journal-article", "published": "2020-09-03", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "15", "issue": "9", "pages": "e0238217", "issn-l": "1932-6203"}, "abstract": null, "doi": "10.1371/journal.pone.0238217", "pmid": null, "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.1371/journal.pone.0238217.s006", "description": "Individual-level data on exposure, perception, and workload collected from 2,707 healthcare professionals from 60 countries"}], "notes": [], "created": "2021-01-26T15:12:12.627Z", "modified": "2021-02-26T08:47:00.279Z"}, {"entity": "publication", "iuid": "19e9898a4a93451b8319e13cc3ea055f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19e9898a4a93451b8319e13cc3ea055f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19e9898a4a93451b8319e13cc3ea055f"}}, "title": "COVID-19 pandemic: implementing control measures in Africa using the 'SHEF2' model.", "authors": [{"family": "Wirsiy", "given": "Frankline Sevidzem", "initials": "FS"}, {"family": "Nkfusai", "given": "Claude Ngwayu", "initials": "CN"}, {"family": "Ako-Arrey", "given": "Denis Ebot", "initials": "DE"}, {"family": "Yeika", "given": "Eugene Vernyuy", "initials": "EV"}, {"family": "Manjong", "given": "Florence Titu", "initials": "FT"}, {"family": "Esther", "given": "Dongmo Kenfack", "initials": "DK"}, {"family": "Nzoyom", "given": "Rosette Boseme", "initials": "RB"}, {"family": "Atuhaire", "given": "Catherine", "initials": "C"}, {"family": "Wirsiy", "given": "Jean-Claude Kindzeka", "initials": "JK"}, {"family": "Cumber", "given": "Samuel Nambile", "initials": "SN"}], "type": "journal article", "published": "2020-09-03", "journal": {"title": "Pan Afr Med J", "issn": "1937-8688", "volume": "37", "issue": "Suppl 1", "pages": "3", "issn-l": null}, "abstract": "The COVID-19 Pandemic in Africa is a severe reminder of the brunt of emerging and re-emerging infectious pathogens and the need for simple, context-oriented, and sustainable health models to combat them when the need arises. In this commentary, an analytical discursive approach was chosen to owe to Africa's unique situation of weak health systems, with most of its member states showing an initial reluctance to deal openly with the COVID-19 situation. This paper discusses five major control measures doped the SHEF2 Model i.e. (\"SHEF2\"- S: Social distancing, H: Hands, E: Elbows, F: Face, F: Feel) of COVID-19 implemented in Africa. We also review the issues related to implementing SHEF2 control measures in Africa. The measures being taken in Asia, Europe, and North America such as social distancing and regular hand washing are a particular challenge for African countries with dense populations, unequal access to water, and limited social safety nets. COVID-19 is challenging the public health and socio-political systems of all affected African countries. The burden of COVID-19 demands rapid and decisive action to be taken, yet the comparison shows how difficult it is was for an unknown new coronavirus disease. In line with the steps being taken across the globe to control and contain COVID-19 pandemic, African countries are preparing for the great effects of this pandemic and ensuing deep recession thus the reason we assert, the greater hope for African countries is implementing an aggressive SHEF2 model strategy. The spread of the pandemic will eventually stop, and the international system will find a balance, but most of the damage will be felt particularly by Africa.", "doi": "10.11604/pamj.supp.2020.37.3.24057", "pmid": "33294104", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "PAMJ-37-1-3"}, {"db": "pmc", "key": "PMC7704345"}], "notes": [], "created": "2020-12-10T09:11:44.724Z", "modified": "2020-12-10T09:13:01.588Z"}, {"entity": "publication", "iuid": "60868faf0ee247319d300b5aaf777e16", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/60868faf0ee247319d300b5aaf777e16.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/60868faf0ee247319d300b5aaf777e16"}}, "title": "A Thematic Analysis of Weibo Topics (Chinese Twitter Hashtags) regarding Older Adults During the COVID-19 Outbreak.", "authors": [{"family": "Xi", "given": "Wanyu", "initials": "W"}, {"family": "Xu", "given": "Wenqian", "initials": "W"}, {"family": "Zhang", "given": "Xin", "initials": "X"}, {"family": "Ayalon", "given": "Liat", "initials": "L"}], "type": "journal article", "published": "2020-09-03", "journal": {"title": "J Gerontol B Psychol Sci Soc Sci", "issn": "1758-5368", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "We explored the portrayal of older adults and the public response to topics concerning older adults during the COVID-19 pandemic in Chinese social media (Weibo topics, equivalent to hashtags on Twitter). We also explored the temporal trends of dominant themes to identify changes over time.\r\n\r\nTopics related to older adults were searched in the Weibo topic search engine between January 20 and April 28, 2020. Overall, 241 topics and their view frequency and comment frequency were collected. Inductive thematic analysis was conducted to classify the topics into themes. The popularity of each theme was also analyzed. In addition, the frequency with which each theme appeared during the three major stages of the pandemic (outbreak, turnover, post-peak) was reported.\r\n\r\nSix main themes were identified. \"Older adults contributing to the community\" was the most prominent theme with the highest average comment frequency per topic. It was also the most dominant theme in the first stage of the pandemic. \"Older patients in hospitals\" was the second most prominent theme, and the most dominant theme in the second and third stages of the pandemic. The percentage of topics with the themes \"Care recipients\" and \"Older adults caring for the young\" increased over time.\r\n\r\nThe portrayal of older people as being warm, competent, and actively exercising their agency is prevalent on Weibo. The Weibo-viewing public shows signs of interest in intergenerational solidarity during the pandemic in China. These findings are different from findings reported by studies conducted in the West.", "doi": "10.1093/geronb/gbaa148", "pmid": "32882029", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "5901075"}, {"db": "pmc", "key": "PMC7499682"}], "notes": [], "created": "2020-12-06T07:31:38.507Z", "modified": "2022-11-10T06:42:21.409Z"}, {"entity": "publication", "iuid": "b117f2dd395849ec983cbe9cebb6bedd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b117f2dd395849ec983cbe9cebb6bedd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b117f2dd395849ec983cbe9cebb6bedd"}}, "title": "Rhabdomyolysis and acute kidney injury in severe COVID-19 infection.", "authors": [{"family": "Taxbro", "given": "Knut", "initials": "K"}, {"family": "Kahlow", "given": "Hannes", "initials": "H"}, {"family": "Wulcan", "given": "Hannes", "initials": "H"}, {"family": "Fornarve", "given": "Anna", "initials": "A"}], "type": "case reports", "published": "2020-09-02", "journal": {"title": "BMJ Case Rep", "issn": "1757-790X", "volume": "13", "issue": "9", "issn-l": null}, "abstract": "We report the case of a 38-year-old man who presented to the emergency department with fever, myalgia, nausea, vomiting, dry cough, breathlessness and abdominal pain. He was admitted due to hypoxaemia and was diagnosed with SARS-CoV-2 and was subsequently referred to the intensive care unit for intubation and mechanical ventilation. Severe rhabdomyolysis and acute kidney injury developed 4 days later and were suspected after noticing discolouration of the urine and a marked increase in plasma myoglobin levels. Treatment included hydration, forced diuresis and continuous renal replacement therapy. In addition to the coronavirus disease acute respiratory distress syndrome, he was diagnosed with possible SARS-CoV-2-induced myositis with severe rhabdomyolysis and kidney failure. The patient survived and was discharged from intensive care after 12 days, returning home 23 days after hospitalisation, fully mobilised with a partially restored kidney function.", "doi": "10.1136/bcr-2020-237616", "pmid": "32878841", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "13/9/e237616"}, {"db": "pmc", "key": "PMC7470512"}], "notes": [], "created": "2020-12-06T07:33:40.982Z", "modified": "2021-02-26T08:45:48.586Z"}, {"entity": "publication", "iuid": "70967c8fd05941d09e83d78ea1c0a572", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70967c8fd05941d09e83d78ea1c0a572.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70967c8fd05941d09e83d78ea1c0a572"}}, "title": "Implementation researchers can improve the responses of services to the COVID-19 pandemic.", "authors": [{"family": "\u00d8vretveit", "given": "John", "initials": "J"}], "type": "journal article", "published": "2020-09-02", "journal": {"title": "Implement Res Pract", "issn": "2633-4895", "volume": "1", "pages": "2633489520949151", "issn-l": null}, "abstract": "This article describes a rapid implementation research project with the Stockholm health care system to assist the system to respond to the COVID-19 pandemic. It uses this example to illustrate some ways in which implementation research and knowledge can contribute to improving service responses to the pandemic and its consequences as these evolve over the coming months. A sub-specialty of rapid implementation science is proposed to provide practical assistance and as one way to develop implementation research.\n\nThis article describes a rapid implementation research project with the Stockholm health care system to assist the system to respond to the COVID-19 pandemic. It uses this example to illustrate some ways in which implementation research and knowledge can contribute to improving service responses to the pandemic and its consequences as these evolve over the coming months. A sub-specialty of rapid implementation science is proposed to provide practical assistance and as one way to develop implementation research.", "doi": "10.1177/2633489520949151", "pmid": "34192265", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1177_2633489520949151"}, {"db": "pmc", "key": "PMC7468666"}], "notes": [], "created": "2021-07-05T14:27:05.143Z", "modified": "2021-07-05T14:27:05.167Z"}, {"entity": "publication", "iuid": "e759bb7be15443c9ada587d3b408877b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e759bb7be15443c9ada587d3b408877b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e759bb7be15443c9ada587d3b408877b"}}, "title": "Excess cardiovascular deaths in the beginning of COVID-19 outbreak", "authors": [{"family": "Wang", "given": "Junren", "initials": "J"}, {"family": "Zhu", "given": "Jianwei", "initials": "J"}, {"family": "Yang", "given": "Huazhen", "initials": "H"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Sun", "given": "Yajing", "initials": "Y"}, {"family": "Ying", "given": "Zhiye", "initials": "Z"}, {"family": "Qu", "given": "Yuanyuan", "initials": "Y"}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA"}, {"family": "Fang", "given": "Fang", "initials": "F"}, {"family": "Song", "given": "Huan", "initials": "H"}], "type": "posted-content", "published": "2020-09-02", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.08.29.20184317", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-09T19:23:35.863Z", "modified": "2021-06-09T19:23:56.032Z"}, {"entity": "publication", "iuid": "2bc302a6f4a44f5d87ded89cf06c3b6e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2bc302a6f4a44f5d87ded89cf06c3b6e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2bc302a6f4a44f5d87ded89cf06c3b6e"}}, "title": "Coronavirus Disease 2019 Related Clinical Studies: A Cross-Sectional Analysis.", "authors": [{"family": "Ma", "given": "Lin-Lu", "initials": "LL"}, {"family": "Yin", "given": "Xuan", "initials": "X"}, {"family": "Li", "given": "Bing-Hui", "initials": "BH"}, {"family": "Yang", "given": "Jia-Yu", "initials": "JY"}, {"family": "Jin", "given": "Ying-Hui", "initials": "YH"}, {"family": "Huang", "given": "Di", "initials": "D"}, {"family": "Deng", "given": "Tong", "initials": "T"}, {"family": "Wang", "given": "Yun-Yun", "initials": "YY"}, {"family": "Ren", "given": "Xue-Qun", "initials": "XQ"}, {"family": "Ji", "given": "Jianguang", "initials": "J"}, {"family": "Zeng", "given": "Xian-Tao", "initials": "XT"}], "type": "journal article", "published": "2020-09-02", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "11", "issue": null, "pages": "540187", "issn-l": "1663-9812"}, "abstract": "The quality and rationality of many recently registered clinical studies related to coronavirus disease 2019 (COVID-19) needs to be assessed. Hence, this study aims to evaluate the current status of COVID-19 related registered clinical trial.\n\nWe did an electronic search of COVID-19 related clinical studies registered between December 1, 2019 and February 21, 2020 (updated to May 28, 2020) from the ClinicalTrials.gov, and collected registration information, study details, recruitment status, characteristics of the subjects, and relevant information about the trial implementation process.\n\nA total of 1,706 studies were included 10.0% of which (n=171) were from France, 943 (55.3%) used an interventional design, and 600 (35.2%) used an observational design. Most of studies (73.6%) aimed to recruit fewer than 500 people. Interferon was the main prevention program, and antiviral drugs were the main treatment program. Hydroxychloroquine and chloroquine (230/943, 24.4%) were widely studied. Some registered clinical trials are incomplete in content, and 37.4% of the 1,706 studies may have had insufficient sample size.\n\nThe quality of COVID-19 related studies needs to be improved by strengthening the registration process and improving the quality of clinical study protocols so that these clinical studies can provide high-quality clinical evidence related to COVID-19.", "doi": "10.3389/fphar.2020.540187", "pmid": "32982751", "labels": {"Type: Journal article": null, "Category: Imaging": null}, "xrefs": [{"db": "pmc", "key": "PMC7492524"}], "notes": [], "created": "2020-12-03T09:36:21.593Z", "modified": "2021-02-26T08:45:36.589Z"}, {"entity": "publication", "iuid": "03ecaaa4c4644762a6707bfd95b232a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/03ecaaa4c4644762a6707bfd95b232a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/03ecaaa4c4644762a6707bfd95b232a6"}}, "title": "Oxytocin's anti-inflammatory and proimmune functions in COVID-19: a transcriptomic signature-based approach.", "authors": [{"family": "Imami", "given": "Ali S", "initials": "AS"}, {"family": "O'Donovan", "given": "Sinead M", "initials": "SM"}, {"family": "Creeden", "given": "Justin F", "initials": "JF"}, {"family": "Wu", "given": "Xiaojun", "initials": "X"}, {"family": "Eby", "given": "Hunter", "initials": "H"}, {"family": "McCullumsmith", "given": "Cheryl B", "initials": "CB"}, {"family": "Uvn\u00e4s-Moberg", "given": "Kerstin", "initials": "K"}, {"family": "McCullumsmith", "given": "Robert E", "initials": "RE"}, {"family": "Andari", "given": "Elissar", "initials": "E"}], "type": "journal article", "published": "2020-09-01", "journal": {"title": "Physiol Genomics", "issn": "1531-2267", "volume": "52", "issue": "9", "pages": "401-407", "issn-l": null}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide pandemic, infecting over 16 million people worldwide with a significant mortality rate. However, there is no current Food and Drug Administration-approved drug that treats coronavirus disease 2019 (COVID-19). Damage to T lymphocytes along with the cytokine storm are important factors that lead to exacerbation of clinical cases. Here, we are proposing intravenous oxytocin (OXT) as a candidate for adjunctive therapy for COVID-19. OXT has anti-inflammatory and proimmune adaptive functions. Using the Library of Integrated Network-Based Cellular Signatures (LINCS), we used the transcriptomic signature for carbetocin, an OXT agonist, and compared it to gene knockdown signatures of inflammatory (such as interleukin IL-1\u03b2 and IL-6) and proimmune markers (including T cell and macrophage cell markers like CD40 and ARG1). We found that carbetocin's transcriptomic signature has a pattern of concordance with inflammation and immune marker knockdown signatures that are consistent with reduction of inflammation and promotion and sustaining of immune response. This suggests that carbetocin may have potent effects in modulating inflammation, attenuating T cell inhibition, and enhancing T cell activation. Our results also suggest that carbetocin is more effective at inducing immune cell responses than either lopinavir or hydroxychloroquine, both of which have been explored for the treatment of COVID-19.", "doi": "10.1152/physiolgenomics.00095.2020", "pmid": "32809918", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [], "notes": [], "created": "2020-12-07T12:49:51.761Z", "modified": "2021-02-26T08:45:02.813Z"}, {"entity": "publication", "iuid": "7325494cd545495586695b3c740af140", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7325494cd545495586695b3c740af140.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7325494cd545495586695b3c740af140"}}, "title": "Outcomes of renin-angiotensin-aldosterone system blockers in patients with COVID-19: a systematic review and meta-analysis.", "authors": [{"family": "Greco", "given": "Antonio", "initials": "A"}, {"family": "Buccheri", "given": "Sergio", "initials": "S"}, {"family": "D'Arrigo", "given": "Paolo", "initials": "P"}, {"family": "Calderone", "given": "Dario", "initials": "D"}, {"family": "Agnello", "given": "Federica", "initials": "F"}, {"family": "Monte", "given": "Marco", "initials": "M"}, {"family": "Milluzzo", "given": "Rocco Paolo", "initials": "RP"}, {"family": "Franchina", "given": "Antonio Gabriele", "initials": "AG"}, {"family": "Ingala", "given": "Salvatore", "initials": "S"}, {"family": "Capodanno", "given": "Davide", "initials": "D"}], "type": "letter", "published": "2020-09-01", "journal": {"title": "Eur Heart J Cardiovasc Pharmacother", "issn": "2055-6845", "volume": "6", "issue": "5", "pages": "335-337", "issn-l": "2055-6837"}, "abstract": null, "doi": "10.1093/ehjcvp/pvaa074", "pmid": "32671399", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "5872101"}, {"db": "pmc", "key": "PMC7454531"}], "notes": [], "created": "2020-11-22T09:22:06.498Z", "modified": "2020-11-30T08:45:14.800Z"}, {"entity": "publication", "iuid": "a664bb8435df4fddb58e270ad7c8b581", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a664bb8435df4fddb58e270ad7c8b581.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a664bb8435df4fddb58e270ad7c8b581"}}, "title": "Explaining the homogeneous diffusion of COVID-19 nonpharmaceutical interventions across heterogeneous countries.", "authors": [{"family": "Sebhatu", "given": "Abiel", "initials": "A"}, {"family": "Wennberg", "given": "Karl", "initials": "K"}, {"family": "Arora-Jonsson", "given": "Stefan", "initials": "S"}, {"family": "Lindberg", "given": "Staffan I", "initials": "SI"}], "type": "journal article", "published": "2020-09-01", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "issn-l": "0027-8424", "volume": "117", "issue": "35", "pages": "21201-21208"}, "abstract": "We analyze the adoption of nonpharmaceutical interventions in the Organisation for Economic Co-operation and Development (OECD) countries during the early phase of the coronavirus disease 2019 (COVID-19) pandemic. Given the complexity associated with pandemic decisions, governments are faced with the dilemma of how to act quickly when their core decision-making processes are based on deliberations balancing political considerations. Our findings show that, in times of severe crisis, governments follow the lead of others and base their decisions on what other countries do. Governments in countries with a stronger democratic structure are slower to react in the face of the pandemic but are more sensitive to the influence of other countries. We provide insights for research on international policy diffusion and research on the political consequences of the COVID-19 pandemic.", "doi": "10.1073/pnas.2010625117", "pmid": "32788356", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "2010625117"}, {"db": "pmc", "key": "PMC7474611"}], "notes": [], "created": "2020-11-19T15:05:37.246Z", "modified": "2022-11-10T06:43:30.755Z"}, {"entity": "publication", "iuid": "6e911372463547cb80b4199fe05ce8f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e911372463547cb80b4199fe05ce8f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e911372463547cb80b4199fe05ce8f4"}}, "title": "Effects of COVID-19 lockdown strategies on management of atrial fibrillation.", "authors": [{"family": "Blomstr\u00f6m-Lundqvist", "given": "Carina", "initials": "C"}], "type": "editorial", "published": "2020-09-01", "journal": {"title": "Eur Heart J", "issn": "1522-9645", "volume": "41", "issue": "32", "pages": "3080-3082", "issn-l": "0195-668X"}, "abstract": "Editorial", "doi": "10.1093/eurheartj/ehaa538", "pmid": "32614939", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5866605"}, {"db": "pmc", "key": "PMC7528957"}], "notes": [], "created": "2020-11-22T08:48:19.135Z", "modified": "2020-12-08T15:07:44.115Z"}, {"entity": "publication", "iuid": "7ae6940fde8344e3bbf1e8e26cebc2d6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7ae6940fde8344e3bbf1e8e26cebc2d6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7ae6940fde8344e3bbf1e8e26cebc2d6"}}, "title": "COVID-19: how things change in a short while.", "authors": [{"family": "Stolfo", "given": "Davide", "initials": "D"}, {"family": "Sinagra", "given": "Gianfranco", "initials": "G"}], "type": "journal article", "published": "2020-09-01", "journal": {"title": "Eur Heart J Cardiovasc Pharmacother", "issn": "2055-6845", "volume": "6", "issue": "5", "pages": "280-281", "issn-l": "2055-6837"}, "abstract": null, "doi": "10.1093/ehjcvp/pvaa092", "pmid": "32678899", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5873153"}, {"db": "pmc", "key": "PMC7454535"}], "notes": [], "created": "2020-12-07T16:34:29.256Z", "modified": "2020-12-07T16:34:29.265Z"}, {"entity": "publication", "iuid": "90ec8d01daeb4319862104f8d124424f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/90ec8d01daeb4319862104f8d124424f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/90ec8d01daeb4319862104f8d124424f"}}, "title": "Avoiding the Banality of Evil in Times of COVID-19: Thinking Differently with a Biopsychosocial Perspective for Future Health and Social Policies Development.", "authors": [{"family": "Leonardi", "given": "Matilde", "initials": "M"}, {"family": "Lee", "given": "Haejung", "initials": "H"}, {"family": "van der Veen", "given": "Sabina", "initials": "S"}, {"family": "Maribo", "given": "Thomas", "initials": "T"}, {"family": "Cuenot", "given": "Marie", "initials": "M"}, {"family": "Simon", "given": "Liane", "initials": "L"}, {"family": "Paltamaa", "given": "Jaana", "initials": "J"}, {"family": "Maart", "given": "Soraya", "initials": "S"}, {"family": "Tucker", "given": "Carole", "initials": "C"}, {"family": "Besstrashnova", "given": "Yanina", "initials": "Y"}, {"family": "Shosmin", "given": "Alexander", "initials": "A"}, {"family": "Cid", "given": "Daniel", "initials": "D"}, {"family": "Almborg", "given": "Ann-Helene", "initials": "AH"}, {"family": "Anttila", "given": "Heidi", "initials": "H"}, {"family": "Yamada", "given": "Shin", "initials": "S"}, {"family": "Frattura", "given": "Lucilla", "initials": "L"}, {"family": "Zavaroni", "given": "Carlo", "initials": "C"}, {"family": "Zhuoying", "given": "Qiu", "initials": "Q"}, {"family": "Martinuzzi", "given": "Andrea", "initials": "A"}, {"family": "Martinuzzi", "given": "Michela", "initials": "M"}, {"family": "Magnani", "given": "Francesca Giulia", "initials": "FG"}, {"family": "Snyman", "given": "Stefanus", "initials": "S"}, {"family": "El Oumri", "given": "Ahmed Amine", "initials": "AA"}, {"family": "Sylvain", "given": "Ndegeya", "initials": "N"}, {"family": "Layton", "given": "Natasha", "initials": "N"}, {"family": "Sykes", "given": "Catherine", "initials": "C"}, {"family": "Saleeby", "given": "Patricia Welch", "initials": "PW"}, {"family": "Winkler", "given": "Andrea Sylvia", "initials": "AS"}, {"family": "de Camargo", "given": "Olaf Kraus", "initials": "OK"}], "type": "journal article", "published": "2020-09-01", "journal": {"title": "SN Compr Clin Med", "issn": "2523-8973", "volume": null, "issue": null, "pages": "1-3", "issn-l": null}, "abstract": "The COVID-19 pandemic provides the opportunity to re-think health policies and health systems approaches by the adoption of a biopsychosocial perspective, thus acting on environmental factors so as to increase facilitators and diminish barriers. Specifically, vulnerable people should not face discrimination because of their vulnerability in the allocation of care or life-sustaining treatments. Adoption of biopsychosocial model helps to identify key elements where to act to diminish effects of the pandemics. The pandemic showed us that barriers in health care organization affect mostly those that are vulnerable and can suffer discrimination not because of severity of diseases but just because of their vulnerability, be this age or disability and this can be avoided by biopsychosocial planning in health and social policies. It is possible to avoid the banality of evil, intended as lack of thinking on what we do when we do, by using the emergence of the emergency of COVID-19 as a Trojan horse to achieve some of the sustainable development goals such as universal health coverage and equity in access, thus acting on environmental factors is the key for global health improvement.", "doi": "10.1007/s42399-020-00486-8", "pmid": "32905109", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "486"}, {"db": "pmc", "key": "PMC7462656"}], "notes": [], "created": "2020-12-03T15:54:02.093Z", "modified": "2020-12-03T15:54:02.118Z"}, {"entity": "publication", "iuid": "70b2e65b6cd84e38a2b89ed18da66416", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/70b2e65b6cd84e38a2b89ed18da66416.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/70b2e65b6cd84e38a2b89ed18da66416"}}, "title": "Association between eating behavior and quarantine/confinement stressors during the coronavirus disease 2019 outbreak.", "authors": [{"family": "Haddad", "given": "Chadia", "initials": "C"}, {"family": "Zakhour", "given": "Maha", "initials": "M"}, {"family": "Bou Kheir", "given": "Maria", "initials": "M"}, {"family": "Haddad", "given": "Rima", "initials": "R"}, {"family": "Al Hachach", "given": "Myriam", "initials": "M"}, {"family": "Sacre", "given": "Hala", "initials": "H"}, {"family": "Salameh", "given": "Pascale", "initials": "P"}], "type": "journal article", "published": "2020-09-01", "journal": {"title": "J Eat Disord", "issn": "2050-2974", "issn-l": null, "volume": "8", "issue": null, "pages": "40"}, "abstract": "Quarantine/confinement is an effective measure to face the Coronavirus disease 2019 (COVID-19). Consequently, in response to this stressful situation, people confined to their homes may change their everyday eating behavior. Therefore, the primary objective of this study is to evaluate the association between quarantine/confinement stressors and eating behavior during the COVID-19 outbreak. The secondary objective is to compare the association of quarantine/confinement stressors and diet behavior between two groups of participants, those attending diet clinics and those not (general population).\r\n\r\nA cross-sectional web-based online survey carried out between April 3 and 18, 2020, enrolled 407 participants from the Lebanese population. Eating Disorder Examination - Questionnaire (EDE-Q) were used to measure the behavioral features of eating disorders.\r\n\r\nMore than half of the sample (53.0%) abide by the home quarantine/confinement, 95.4% were living with someone in the quarantine/confinement, and 39.6% continued to work from home. Higher fear of COVID-19 was found in 182 (44.8%) participants, higher boredom in 200 (49.2%) participants, higher anger in 187 (46.3%), and higher anxiety in 197 (48.5%) participants. Higher fear of COVID-19 (Beta = 0.02), higher BMI (Beta = 0.05), and physical activity (Beta = 1.04) were significantly associated with a higher restraint score. Higher anxiety, higher fear of COVID-19, higher BMI, practicing physical exercise, and a higher number of adults living in the quarantine/confinement were significantly associated with higher shape and weight concerns.\r\n\r\nOur results showed that the fear of COVID-19 was correlated with more eating restraint, weight, and shape concerns in the whole sample, but more specifically in the dietitian clients group. Public health control measures are needed to reduce the detrimental effects of psychological distress associated with quarantine/confinement on eating behaviors during the COVID-19 outbreak.", "doi": "10.1186/s40337-020-00317-0", "pmid": "32879730", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "317"}, {"db": "pmc", "key": "PMC7458649"}], "notes": [], "created": "2020-12-06T07:32:44.998Z", "modified": "2022-11-10T06:47:03.755Z"}, {"entity": "publication", "iuid": "a8d0a2f042ac48f8ab2a981f039d2479", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a8d0a2f042ac48f8ab2a981f039d2479.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a8d0a2f042ac48f8ab2a981f039d2479"}}, "title": "Vitamin D deficiency and the COVID-19 pandemic.", "authors": [{"family": "Zemb", "given": "Patrick", "initials": "P"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Camargo", "given": "Carlos A", "initials": "CA"}, {"family": "Cavalier", "given": "Etienne", "initials": "E"}, {"family": "Cormier", "given": "Catherine", "initials": "C"}, {"family": "Courbebaisse", "given": "Marie", "initials": "M"}, {"family": "Hollis", "given": "Bruce", "initials": "B"}, {"family": "Joulia", "given": "Fabrice", "initials": "F"}, {"family": "Minisola", "given": "Salvatore", "initials": "S"}, {"family": "Pilz", "given": "Stefan", "initials": "S"}, {"family": "Pludowski", "given": "Pawel", "initials": "P"}, {"family": "Schmitt", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Zdrenghea", "given": "Mihnea", "initials": "M"}, {"family": "Souberbielle", "given": "Jean-Claude", "initials": "JC"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "J Glob Antimicrob Resist", "issn": "2213-7173", "volume": "22", "issue": null, "pages": "133-134", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jgar.2020.05.006", "pmid": "32474141", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-7165(20)30132-6"}, {"db": "pmc", "key": "PMC7256612"}], "notes": [], "created": "2020-12-09T10:59:00.344Z", "modified": "2020-12-09T10:59:00.366Z"}, {"entity": "publication", "iuid": "b1573fb6875347c485fd5af422886c13", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b1573fb6875347c485fd5af422886c13.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b1573fb6875347c485fd5af422886c13"}}, "title": "Travel-associated COVID-19: a challenge for surveillance?", "authors": [{"family": "Beaut\u00e9", "given": "Julien", "initials": "J"}, {"family": "Spiteri", "given": "Gianfranco", "initials": "G"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "37", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.37.2001641", "pmid": "32945253", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7502887"}], "notes": [], "created": "2020-12-03T15:26:13.762Z", "modified": "2020-12-03T15:26:13.772Z"}, {"entity": "publication", "iuid": "c168f9f298ba441cb13488e8fa8a9709", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c168f9f298ba441cb13488e8fa8a9709.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c168f9f298ba441cb13488e8fa8a9709"}}, "title": "Transmission of SARS-CoV-2 in children aged 0 to 19 years in childcare facilities and schools after their reopening in May 2020, Baden-W\u00fcrttemberg, Germany.", "authors": [{"family": "Ehrhardt", "given": "J", "initials": "J"}, {"family": "Ekinci", "given": "A", "initials": "A"}, {"family": "Krehl", "given": "H", "initials": "H"}, {"family": "Meincke", "given": "M", "initials": "M"}, {"family": "Finci", "given": "I", "initials": "I"}, {"family": "Klein", "given": "J", "initials": "J"}, {"family": "Geisel", "given": "B", "initials": "B"}, {"family": "Wagner-Wiening", "given": "C", "initials": "C"}, {"family": "Eichner", "given": "M", "initials": "M"}, {"family": "Brockmann", "given": "S O", "initials": "SO"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "36", "issn-l": null}, "abstract": "We investigated data from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected 0-19 year olds, who attended schools/childcare facilities, to assess their role in SARS-CoV-2 transmission after these establishments' reopening in May 2020 in Baden-W\u00fcrttemberg, Germany. Child-to-child transmission in schools/childcare facilities appeared very uncommon. We anticipate that, with face mask use and frequent ventilation of rooms, transmission rates in schools/childcare facilities would remain low in the next term, even if classes' group sizes were increased.", "doi": "10.2807/1560-7917.ES.2020.25.36.2001587", "pmid": "32914746", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7502898"}], "notes": [], "created": "2020-12-03T15:49:58.334Z", "modified": "2021-02-26T08:45:48.653Z"}, {"entity": "publication", "iuid": "88f2b1b690ab477d9fe2589437f08ec1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/88f2b1b690ab477d9fe2589437f08ec1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/88f2b1b690ab477d9fe2589437f08ec1"}}, "title": "Towards pandemic preparedness beyond COVID-19", "authors": [{"family": "Naguib", "given": "Mahmoud M", "initials": "MM"}, {"family": "Ellstr\u00f6m", "given": "Patrik", "initials": "P"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Olsen", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal-article", "published": "2020-09-00", "journal": {"title": "The Lancet Microbe", "issn": "2666-5247", "issn-l": "2666-5247", "volume": "1", "issue": "5", "pages": "e185-e186"}, "abstract": "Review", "doi": "10.1016/s2666-5247(20)30088-4", "pmid": "32838347", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-04T07:08:50.155Z", "modified": "2020-12-11T12:51:10.950Z"}, {"entity": "publication", "iuid": "a9b3c57bb27342faaaa07bd80d8ed5c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a9b3c57bb27342faaaa07bd80d8ed5c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a9b3c57bb27342faaaa07bd80d8ed5c9"}}, "title": "The use of positive end expiratory pressure in patients affected by COVID-19: Time to reconsider the relation between morphology and physiology.", "authors": [{"family": "Perchiazzi", "given": "Gaetano", "initials": "G", "orcid": "0000-0001-6834-6399", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ef9ffc76bfe47c5afff104e9aaef020.json"}}, {"family": "Pellegrini", "given": "Mariangela", "initials": "M"}, {"family": "Chiodaroli", "given": "Elena", "initials": "E"}, {"family": "Urits", "given": "Ivan", "initials": "I"}, {"family": "Kaye", "given": "Alan D", "initials": "AD"}, {"family": "Viswanath", "given": "Omar", "initials": "O"}, {"family": "Varrassi", "given": "Giustino", "initials": "G"}, {"family": "Puntillo", "given": "Filomena", "initials": "F"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Best Pract Res Clin Anaesthesiol", "issn": "1878-1608", "volume": "34", "issue": "3", "pages": "561-567", "issn-l": "1753-3740"}, "abstract": "Coronavirus disease 2019 (COVID-19) is a new disease with different phases that can be catastrophic for subpopulations of patients with cardiovascular and pulmonary disease states at baseline. Appreciation for these different phases and treatment modalities, including manipulation of ventilatory settings and therapeutics, has made it a less lethal disease than when it emerged earlier this year. Different aspects of the disease are still largely unknown. However, laboratory investigation and clinical course of the COVID-19 show that this new disease is not a typical acute respiratory distress syndrome process, especially during the first phase. For this reason, the best strategy to be applied is to treat differently the single phases and to support the single functions of the failing organs as they appear.", "doi": "10.1016/j.bpa.2020.07.007", "pmid": "33004167", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7367781"}, {"db": "pii", "key": "S1521-6896(20)30062-8"}], "notes": [], "created": "2020-11-27T12:40:00.890Z", "modified": "2023-06-19T15:20:22.345Z"}, {"entity": "publication", "iuid": "2e1cf5a5227047e5988485212dca347c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e1cf5a5227047e5988485212dca347c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e1cf5a5227047e5988485212dca347c"}}, "title": "The Rheumatologist's Role in the Battle Against COVID-19: Insights from the Front Line and Challenges for the Future.", "authors": [{"family": "Koutsianas", "given": "Christos", "initials": "C"}, {"family": "Chatzidionysiou", "given": "Katerina", "initials": "K"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Mediterr J Rheumatol", "issn": "2529-198X", "volume": "31", "issue": "Suppl 2", "pages": "247-252", "issn-l": "2529-198X"}, "abstract": "As the worldwide burden of COVID-19 increases exponentially, healthcare systems are plagued by unprecedented pressure. In this setting, many rheumatologists across the globe have been recruited to support the front line, facing several unexpected challenges, but also providing valuable skills in combating COVID-19. At the same time, the rheumatic disease patient population may be especially vulnerable to such a rapidly contagious infectious disease and thus needs care and support that has to be provided quickly and efficiently. Clear advice on viral spread mitigation, precise guidelines on immunosuppressive treatment use and alternative methods of providing care, such as telemedicine, are a few of the rheumatologists' new challenges in caring for their patients in the COVID-19 era. Finally, among other specialties, rheumatologists hold a unique place in the fight against the hyper-inflammatory state caused by severe SARS-CoV-2 infection, leading to increased morbidity and mortality. Given their vast experience in the use of biologic and targeted therapies, rheumatologists should lead the way in developing reliable scientific evidence for the optimal treatment of severe COVID-19.", "doi": "10.31138/mjr.31.3.247", "pmid": "33196000", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "MJR-31-Suppl-2-247"}, {"db": "pmc", "key": "PMC7656125"}], "notes": [], "created": "2020-11-27T09:54:48.746Z", "modified": "2020-11-27T09:54:48.765Z"}, {"entity": "publication", "iuid": "7471dd74cf97437cb31db057a3d55c78", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7471dd74cf97437cb31db057a3d55c78.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7471dd74cf97437cb31db057a3d55c78"}}, "title": "The Covid-19 pandemic stress the need to build resilient production ecosystems", "authors": [{"family": "Gordon", "given": "Line J", "initials": "LJ"}], "type": "journal-article", "published": "2020-09-00", "journal": {"title": "Agric Human Values", "issn": "0889-048X", "volume": "37", "issue": "3", "pages": "645-646", "issn-l": null}, "abstract": null, "doi": "10.1007/s10460-020-10105-w", "pmid": "32836746", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10105"}, {"db": "pmc", "key": "PMC7245175"}], "notes": [], "created": "2020-12-07T11:32:08.285Z", "modified": "2021-12-06T13:18:20.606Z"}, {"entity": "publication", "iuid": "9ab6469f5a1445fba99bd72512ac0851", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ab6469f5a1445fba99bd72512ac0851.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ab6469f5a1445fba99bd72512ac0851"}}, "title": "The Association between Out-of-Pocket Expenditure and COVID-19 Mortality Globally.", "authors": [{"family": "El-Khatib", "given": "Ziad", "initials": "Z"}, {"family": "Otu", "given": "Akaninyene", "initials": "A"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}, {"family": "Yaya", "given": "Sanni", "initials": "S"}], "type": "letter", "published": "2020-09-00", "journal": {"title": "J Epidemiol Glob Health", "issn": "2210-6014", "issn-l": null, "volume": "10", "issue": "3", "pages": "192-193"}, "abstract": null, "doi": "10.2991/jegh.k.200725.001", "pmid": "32954706", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "j10/3/192"}, {"db": "pmc", "key": "PMC7509105"}], "notes": [], "created": "2020-12-03T09:27:59.119Z", "modified": "2021-02-26T08:47:00.100Z"}, {"entity": "publication", "iuid": "97292f4104f541cd96c0c9e68bbb847a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/97292f4104f541cd96c0c9e68bbb847a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/97292f4104f541cd96c0c9e68bbb847a"}}, "title": "The \"Vascular Surgery COVID-19 Collaborative\" (VASCC).", "authors": [{"family": "D'Oria", "given": "Mario", "initials": "M"}, {"family": "Mills", "given": "Joseph L", "initials": "JL"}, {"family": "Cohnert", "given": "Tina", "initials": "T"}, {"family": "Oderich", "given": "Gustavo S", "initials": "GS"}, {"family": "Hultgren", "given": "Rebecka", "initials": "R"}, {"family": "Lepidi", "given": "Sandro", "initials": "S"}, {"family": "Vascular Surgery COVID-19 Collaborative (VASCC)", "given": "", "initials": ""}], "type": "letter", "published": "2020-09-00", "journal": {"title": "Eur J Vasc Endovasc Surg", "issn": "1532-2165", "volume": "60", "issue": "3", "pages": "489-490", "issn-l": "1078-5884"}, "abstract": null, "doi": "10.1016/j.ejvs.2020.07.072", "pmid": "32798205", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1078-5884(20)30683-3"}, {"db": "pmc", "key": "PMC7388790"}], "notes": [], "created": "2020-12-07T13:22:26.320Z", "modified": "2020-12-07T13:22:26.330Z"}, {"entity": "publication", "iuid": "c76f6a1bc4f249ad8b183996150078a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c76f6a1bc4f249ad8b183996150078a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c76f6a1bc4f249ad8b183996150078a0"}}, "title": "Targeting TMPRSS2 in SARS-CoV-2 Infection.", "authors": [{"family": "Baughn", "given": "Linda B", "initials": "LB"}, {"family": "Sharma", "given": "Neeraj", "initials": "N"}, {"family": "Elhaik", "given": "Eran", "initials": "E"}, {"family": "Sekulic", "given": "Aleksandar", "initials": "A"}, {"family": "Bryce", "given": "Alan H", "initials": "AH"}, {"family": "Fonseca", "given": "Rafael", "initials": "R"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Mayo Clin Proc", "issn": "1942-5546", "volume": "95", "issue": "9", "pages": "1989-1999", "issn-l": "0025-6196"}, "abstract": "Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has rapidly caused a global pandemic associated with a novel respiratory infection: coronavirus disease-19 (COVID-19). Angiotensin-converting enzyme-2 (ACE2) is necessary to facilitate SARS-CoV-2 infection, but-owing to its essential metabolic roles-it may be difficult to target it in therapies. Transmembrane protease serine 2 (TMPRSS2), which interacts with ACE2, may be a better candidate for targeted therapies. Using publicly available expression data, we show that both ACE2 and TMPRSS2 are expressed in many host tissues, including lung. The highest expression of ACE2 is found in the testes, whereas the prostate displays the highest expression of TMPRSS2. Given the increased severity of disease among older men with SARS-CoV-2 infection, we address the potential roles of ACE2 and TMPRSS2 in their contribution to the sex differences in severity of disease. We show that expression levels of ACE2 and TMPRSS2 are overall comparable between men and women in multiple tissues, suggesting that differences in the expression levels of TMPRSS2 and ACE2 in the lung and other non-sex-specific tissues may not explain the gender disparities in severity of SARS CoV-2. However, given their instrumental roles for SARS-CoV-2 infection and their pleiotropic expression, targeting the activity and expression levels of TMPRSS2 is a rational approach to treat COVID-19.", "doi": "10.1016/j.mayocp.2020.06.018", "pmid": "32861340", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S0025-6196(20)30626-1"}, {"db": "pmc", "key": "PMC7368885"}], "notes": [], "created": "2020-12-07T10:20:25.960Z", "modified": "2021-02-26T08:45:03.245Z"}, {"entity": "publication", "iuid": "ff7fb22175a8472799663bb90467ac15", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff7fb22175a8472799663bb90467ac15.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff7fb22175a8472799663bb90467ac15"}}, "title": "Prioritizing Cleft/Craniofacial Surgical Care after the COVID-19 Pandemic.", "authors": [{"family": "Breugem", "given": "Corstiaan", "initials": "C"}, {"family": "Smit", "given": "Hans", "initials": "H"}, {"family": "Mark", "given": "Hans", "initials": "H"}, {"family": "Davies", "given": "Gareth", "initials": "G"}, {"family": "Schachner", "given": "Peter", "initials": "P"}, {"family": "Collard", "given": "Mechelle", "initials": "M"}, {"family": "Sell", "given": "Debbie", "initials": "D"}, {"family": "Autelitano", "given": "Luca", "initials": "L"}, {"family": "Rezzonico", "given": "Angela", "initials": "A"}, {"family": "Mazzoleni", "given": "Fabio", "initials": "F"}, {"family": "Novelli", "given": "Giorgio", "initials": "G"}, {"family": "Mossey", "given": "Peter", "initials": "P"}, {"family": "Persson", "given": "Martin", "initials": "M"}, {"family": "Mehendale", "given": "Felicity", "initials": "F"}, {"family": "Gaggl", "given": "Alexander", "initials": "A"}, {"family": "van Gogh", "given": "Christine", "initials": "C"}, {"family": "Zuurbier", "given": "Petra", "initials": "P"}, {"family": "Reinart", "given": "Siegmar", "initials": "S"}, {"family": "de Graaff", "given": "Feike", "initials": "F"}, {"family": "Meazzini", "given": "Costanza", "initials": "C"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Plast Reconstr Surg Glob Open", "issn": "2169-7574", "volume": "8", "issue": "9", "pages": "e3080", "issn-l": null}, "abstract": "It is anticipated that in due course the burden of emergency care due to COVID-19 infected patients will reduce sufficiently to permit elective surgical procedures to recommence. Prioritizing cleft/craniofacial surgery in the already overloaded medical system will then become an issue. The European Cleft Palate Craniofacial Association, together with the European Cleft and Craniofacial Initiative for Equality in Care, performed a brief survey to capture a current snapshot during a rapidly evolving pandemic.\n\nA questionnaire was sent to the 2242 participants who attended 1 of 3 recent international cleft/craniofacial meetings.\n\nThe respondents indicated that children with Robin sequence who were not responding to nonsurgical options should be treated as emergency cases. Over 70% of the respondents indicated that palate repair should be performed before the age of 15 months, an additional 22% stating the same be performed by 18 months. Placement of middle ear tubes, primary cleft lip surgery, alveolar bone grafting, and velopharyngeal insufficiency surgery also need prioritization. Children with craniofacial conditions such as craniosynostosis and increased intracranial pressure need immediate care, whilst children with craniosynostosis and associated obstructive sleep apnea syndrome or proptosis need surgical care within 3 months of the typical timing. Craniosynostosis without signs of increased intracranial pressure needs correction before the age of 18 months.\n\nThis survey indicates several areas of cleft and craniofacial conditions that need prioritization, but also certain areas where intervention is less urgent. We acknowledge that there will be differences in the post COVID-19 response according to circumstances and policies in individual countries.", "doi": "10.1097/GOX.0000000000003080", "pmid": "33133937", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7544383"}], "notes": [], "created": "2020-12-01T15:01:18.453Z", "modified": "2021-02-26T08:45:48.934Z"}, {"entity": "publication", "iuid": "679be0bb5b0c492f8c69165fadf5dfb2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/679be0bb5b0c492f8c69165fadf5dfb2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/679be0bb5b0c492f8c69165fadf5dfb2"}}, "title": "Predicted COVID-19 fatality rates based on age, sex, comorbidities and health system capacity.", "authors": [{"family": "Ghisolfi", "given": "Selene", "initials": "S"}, {"family": "Alm\u00e5s", "given": "Ingvild", "initials": "I"}, {"family": "Sandefur", "given": "Justin C", "initials": "JC"}, {"family": "von Carnap", "given": "Tillman", "initials": "T"}, {"family": "Heitner", "given": "Jesse", "initials": "J"}, {"family": "Bold", "given": "Tessa", "initials": "T"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "5", "issue": "9", "issn-l": "2059-7908"}, "abstract": "Early reports suggest the fatality rate from COVID-19 varies greatly across countries, but non-random testing and incomplete vital registration systems render it impossible to directly estimate the infection fatality rate (IFR) in many low- and middle-income countries. To fill this gap, we estimate the adjustments required to extrapolate estimates of the IFR from high-income to lower-income regions. Accounting for differences in the distribution of age, sex and relevant comorbidities yields substantial differences in the predicted IFR across 21 world regions, ranging from 0.11% in Western Sub-Saharan Africa to 1.07% for high-income Asia Pacific. However, these predictions must be treated as lower bounds in low- and middle-income countries as they are grounded in fatality rates from countries with advanced health systems. To adjust for health system capacity, we incorporate regional differences in the relative odds of infection fatality from childhood respiratory syncytial virus. This adjustment greatly diminishes but does not entirely erase the demography-based advantage predicted in the lowest income settings, with regional estimates of the predicted COVID-19 IFR ranging from 0.37% in Western Sub-Saharan Africa to 1.45% for Eastern Europe.", "doi": "10.1136/bmjgh-2020-003094", "pmid": "32912856", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-003094"}, {"db": "pmc", "key": "PMC7482102"}], "notes": [], "created": "2020-11-27T12:43:18.757Z", "modified": "2020-11-27T12:43:18.768Z"}, {"entity": "publication", "iuid": "0210f1afaeb74e4d9082a7d9ba9f8162", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0210f1afaeb74e4d9082a7d9ba9f8162.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0210f1afaeb74e4d9082a7d9ba9f8162"}}, "title": "Population-level COVID-19 mortality risk for non-elderly individuals overall and for non-elderly individuals without underlying diseases in pandemic epicenters.", "authors": [{"family": "Ioannidis", "given": "John P A", "initials": "JPA"}, {"family": "Axfors", "given": "Cathrine", "initials": "C"}, {"family": "Contopoulos-Ioannidis", "given": "Despina G", "initials": "DG"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Environ Res", "issn": "1096-0953", "issn-l": "0013-9351", "volume": "188", "issue": null, "pages": "109890"}, "abstract": "To provide estimates of the relative rate of COVID-19 death in people <65 years old versus older individuals in the general population, the absolute risk of COVID-19 death at the population level during the first epidemic wave, and the proportion of COVID-19 deaths in non-elderly people without underlying diseases in epicenters of the pandemic.\r\n\r\nCross-sectional survey of countries and US states with at least 800 COVID-19 deaths as of April 24, 2020 and with information on the number of deaths in people with age <65. Data were available for 14 countries (Belgium, Canada, France, Germany, India, Ireland, Italy, Mexico, Netherlands, Portugal, Spain, Sweden, Switzerland, UK) and 13 US states (California, Connecticut, Florida, Georgia, Illinois, Indiana, Louisiana, Maryland, Massachusetts, Michigan, New Jersey, New York, Pennsylvania). We also examined available data on COVID-19 deaths in people with age <65 and no underlying diseases.\r\n\r\nProportion of COVID-19 deaths in people <65 years old; relative mortality rate of COVID-19 death in people <65 versus \u226565 years old; absolute risk of COVID-19 death in people <65 and in those \u226580 years old in the general population as of June 17, 2020; absolute COVID-19 mortality rate expressed as equivalent of mortality rate from driving a motor vehicle.\r\n\r\nIndividuals with age <65 account for 4.5-11.2% of all COVID-19 deaths in European countries and Canada, 8.3-22.7% in the US locations, and were the majority in India and Mexico. People <65 years old had 30- to 100-fold lower risk of COVID-19 death than those \u226565 years old in 11 European countries and Canada, 16- to 52-fold lower risk in US locations, and less than 10-fold in India and Mexico. The absolute risk of COVID-19 death as of June 17, 2020 for people <65 years old in high-income countries ranged from 10 (Germany) to 349 per million (New Jersey) and it was 5 per million in India and 96 per million in Mexico. The absolute risk of COVID-19 death for people \u226580 years old ranged from 0.6 (Florida) to 17.5 per thousand (Connecticut). The COVID-19 mortality rate in people <65 years old during the period of fatalities from the epidemic was equivalent to the mortality rate from driving between 4 and 82 miles per day for 13 countries and 5 states, and was higher (equivalent to the mortality rate from driving 106-483 miles per day) for 8 other states and the UK. People <65 years old without underlying predisposing conditions accounted for only 0.7-3.6% of all COVID-19 deaths in France, Italy, Netherlands, Sweden, Georgia, and New York City and 17.7% in Mexico.\r\n\r\nPeople <65 years old have very small risks of COVID-19 death even in pandemic epicenters and deaths for people <65 years without underlying predisposing conditions are remarkably uncommon. Strategies focusing specifically on protecting high-risk elderly individuals should be considered in managing the pandemic.", "doi": "10.1016/j.envres.2020.109890", "pmid": "32846654", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S0013-9351(20)30785-4"}, {"db": "pmc", "key": "PMC7327471"}, {"db": "URL", "key": "https://ars.els-cdn.com/content/image/1-s2.0-S0013935120307854-mmc2.pdf", "description": "Number of COVID-19 deaths contributed by specific age group and population characteristics for 14 countries and 13 US states"}], "notes": [], "created": "2020-11-22T09:56:51.290Z", "modified": "2021-02-26T08:46:59.789Z"}, {"entity": "publication", "iuid": "536b4d0da2254331a79a3bf4d5693abc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/536b4d0da2254331a79a3bf4d5693abc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/536b4d0da2254331a79a3bf4d5693abc"}}, "title": "Per capita death and infection rates should be avoided in international comparisons.", "authors": [{"family": "Silva", "given": "W T A F", "initials": "WTAF"}], "type": "letter", "published": "2020-09-00", "journal": {"title": "Public Health", "issn": "1476-5616", "volume": "186", "issue": null, "pages": "18-19", "issn-l": null}, "abstract": null, "doi": "10.1016/j.puhe.2020.06.038", "pmid": "32750504", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0033-3506(20)30276-6"}, {"db": "pmc", "key": "PMC7395585"}], "notes": [], "created": "2020-12-07T15:48:12.388Z", "modified": "2020-12-07T15:48:12.410Z"}, {"entity": "publication", "iuid": "c1f02d70a3814642add901ea579ed297", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1f02d70a3814642add901ea579ed297.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1f02d70a3814642add901ea579ed297"}}, "title": "Peer Review Week 2020: Eurosurveillance thanks all COVID-19 reviewers for their amazing work.", "authors": [{"family": "Eurosurveillance editorial team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "38", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.38.2009242", "pmid": "32975183", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7533617"}], "notes": [], "created": "2020-12-03T14:32:25.284Z", "modified": "2020-12-03T14:32:25.294Z"}, {"entity": "publication", "iuid": "5a93a8b03dbb42fba1d041a2c4b25fcc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5a93a8b03dbb42fba1d041a2c4b25fcc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5a93a8b03dbb42fba1d041a2c4b25fcc"}}, "title": "Management of the emergency response to the SARS-CoV-2 (COVID-19) outbreak in Stockholm, Sweden, and winter preparations.", "authors": [{"family": "Ohrling", "given": "Mikael", "initials": "M"}, {"family": "\u00d8vretveit", "given": "John", "initials": "J"}, {"family": "Lockowandt", "given": "Ulf", "initials": "U"}, {"family": "Brommels", "given": "Mats", "initials": "M"}, {"family": "Sparring", "given": "Vibeke", "initials": "V"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "J Prim Health Care", "issn": "1172-6156", "volume": "12", "issue": "3", "pages": "207-214", "issn-l": null}, "abstract": "INTRODUCTION Sweden is unique in adopting a 'no-lockdown' public health approach to the SARS-CoV-2 (COVID-19) outbreak. There were fears that health services would not be able to care for high numbers of COVID-19 patients. AIM To describe and review the emergency response of a public primary and community health-care organisation in Stockholm, Sweden, to the demand for care for COVID-19 and non-COVID-19 patients during March-July 2020, and summarise preparations for the months to follow. METHODS This was a rapid implementation action research case study, which also draws on one author's experience as Chief Executive Officer and other members' experience in an emergency management group. RESULTS Sweden experienced similar mortality per million population to the UK, despite the different public health strategy used to address the COVID-19 outbreak. The Stockholm-integrated public primary and community health-care service, serving a population of 2.3 million, made many changes quickly. One change included coordinating non-acute private health-care services, following the local government emergency directive to do so. DISCUSSION It is possible that the fast and effective response by management and services in primary and community health care reduced infection and hospital demand, which contributed to a lower mortality than otherwise expected. The actions and preparations described for Stockholm's response may provide ideas for other health-care systems. The partnership research approach between the Karolinska Medical University and the Region Stockholm health-care system used in this project shows that rapid research methods have advantages for both partners in an emergency situation.", "doi": "10.1071/HC20082", "pmid": "32988442", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "HC20082"}], "notes": [], "created": "2020-11-27T12:40:02.016Z", "modified": "2020-11-27T12:40:02.043Z"}, {"entity": "publication", "iuid": "f6a0171db3c84f31880fcd505070a25c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f6a0171db3c84f31880fcd505070a25c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f6a0171db3c84f31880fcd505070a25c"}}, "title": "Investigating mediated effects of fear of COVID-19 and COVID-19 misunderstanding in the association between problematic social media use, psychological distress, and insomnia.", "authors": [{"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Internet Interv", "issn": "2214-7829", "volume": "21", "issue": null, "pages": "100345", "issn-l": "2214-7829"}, "abstract": "Due to the serious situation of the novel coronavirus disease 2019 (COVID-19) worldwide, many countries have implemented policies to minimize the spread of COVID-19 infection. However, some of these policies prevent people from physical contact. Consequently, many individuals may rely on social media to obtain information concerning COVID-19. Unfortunately, social media use (especially problematic social media use) may give rise to psychological distress. Therefore, this study thus examined potential psychopathology to explain the association between problematic social media use, psychological distress, and insomnia.\n\nUtilizing an online survey, a sample of Iranian young adults (n = 1078 with 628 males; mean age = 26.24 years [SD \u00b1 7.41]) completed questions and psychometric scales concerning psychological distress, insomnia, problematic social media use, fear of COVID-19, and COVID-19 misunderstanding.\n\nProblematic social media use was significantly associated with psychological distress both directly and indirectly. The indirect effects were through fear of COVID-19 (unstandardized coefficient [B] = 0.177; Bootstrapping SE = 0.026) and COVID-19 misunderstanding (B = 0.060; Bootstrapping SE = 0.014). Problematic social media use was significantly associated with insomnia both directly and indirectly. The indirect effect was through fear of COVID-19 (B = 0.062; Bootstrapping SE = 0.019) but not COVID-19 misunderstanding (B = 0.012; Bootstrapping SE = 0.014).\n\nDue to the pressure of the COVID-19 outbreak, individuals are highly likely to develop psychological distress and insomnia. Apart from developing appropriate health policies to minimize the spread of COVID-19 infection, healthcare providers should design appropriate online campaigns to eliminate people's fear of COVID-19 and to diminish misunderstanding concerning COVID-19.", "doi": "10.1016/j.invent.2020.100345", "pmid": "32868992", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2214-7829(20)30111-1"}, {"db": "pii", "key": "100345"}, {"db": "pmc", "key": "PMC7449889"}], "notes": [], "created": "2020-12-07T07:49:52.173Z", "modified": "2021-02-26T08:45:48.868Z"}, {"entity": "publication", "iuid": "c4ef5f067c2a45bfba4aecc0e83e2ae4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c4ef5f067c2a45bfba4aecc0e83e2ae4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c4ef5f067c2a45bfba4aecc0e83e2ae4"}}, "title": "International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells: considerations for potential therapeutic agents to suppress coronavirus disease-19.", "authors": [{"family": "B\u00f6rger", "given": "Verena", "initials": "V"}, {"family": "Weiss", "given": "Daniel J", "initials": "DJ"}, {"family": "Anderson", "given": "Johnathon D", "initials": "JD"}, {"family": "Borr\u00e0s", "given": "Francesc E", "initials": "FE"}, {"family": "Bussolati", "given": "Benedetta", "initials": "B"}, {"family": "Carter", "given": "David R F", "initials": "DRF"}, {"family": "Dominici", "given": "Massimo", "initials": "M"}, {"family": "Falc\u00f3n-P\u00e9rez", "given": "Juan M", "initials": "JM"}, {"family": "Gimona", "given": "Mario", "initials": "M"}, {"family": "Hill", "given": "Andrew F", "initials": "AF"}, {"family": "Hoffman", "given": "Andrew M", "initials": "AM"}, {"family": "de Kleijn", "given": "Dominique", "initials": "D"}, {"family": "Levine", "given": "Bruce L", "initials": "BL"}, {"family": "Lim", "given": "Rebecca", "initials": "R"}, {"family": "L\u00f6tvall", "given": "Jan", "initials": "J"}, {"family": "Mitsialis", "given": "S Alex", "initials": "SA"}, {"family": "Mongui\u00f3-Tortajada", "given": "Marta", "initials": "M"}, {"family": "Muraca", "given": "Maurizio", "initials": "M"}, {"family": "Nieuwland", "given": "Rienk", "initials": "R"}, {"family": "Nowocin", "given": "Anna", "initials": "A"}, {"family": "O'Driscoll", "given": "Lorraine", "initials": "L"}, {"family": "Ortiz", "given": "Luis A", "initials": "LA"}, {"family": "Phinney", "given": "Donald G", "initials": "DG"}, {"family": "Reischl", "given": "Ilona", "initials": "I"}, {"family": "Rohde", "given": "Eva", "initials": "E"}, {"family": "Sanzenbacher", "given": "Ralf", "initials": "R"}, {"family": "Th\u00e9ry", "given": "Clotilde", "initials": "C"}, {"family": "Toh", "given": "Wei Seong", "initials": "WS"}, {"family": "Witwer", "given": "Kenneth W", "initials": "KW"}, {"family": "Lim", "given": "Sai Kiang", "initials": "SK"}, {"family": "Giebel", "given": "Bernd", "initials": "B"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Cytotherapy", "issn": "1477-2566", "issn-l": "1465-3249", "volume": "22", "issue": "9", "pages": "482-485"}, "abstract": "The International Society for Cellular and Gene Therapies (ISCT) and the International Society for Extracellular Vesicles (ISEV) recognize the potential of extracellular vesicles (EVs, including exosomes) from mesenchymal stromal cells (MSCs) and possibly other cell sources as treatments for COVID-19. Research and trials in this area are encouraged. However, ISEV and ISCT do not currently endorse the use of EVs or exosomes for any purpose in COVID-19, including but not limited to reducing cytokine storm, exerting regenerative effects or delivering drugs, pending the generation of appropriate manufacturing and quality control provisions, pre-clinical safety and efficacy data, rational clinical trial design and proper regulatory oversight.", "doi": "10.1016/j.jcyt.2020.05.002", "pmid": "32425691", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1465-3249(20)30662-9"}, {"db": "pmc", "key": "PMC7229942"}], "notes": [], "created": "2020-12-09T11:42:20.533Z", "modified": "2020-12-09T11:43:02.272Z"}, {"entity": "publication", "iuid": "f5b6380c3bbe4d49872fd22bd68b6c42", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f5b6380c3bbe4d49872fd22bd68b6c42.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f5b6380c3bbe4d49872fd22bd68b6c42"}}, "title": "Impact on hospital admission of ST-elevation myocardial infarction patients during coronavirus disease 2019 pandemic in an Italian Hospital.", "authors": [{"family": "Di Liberto", "given": "Ilenia Alessandra", "initials": "IA"}, {"family": "Pilato", "given": "Gerlando", "initials": "G"}, {"family": "Geraci", "given": "Salvatore", "initials": "S"}, {"family": "Milazzo", "given": "Diego", "initials": "D"}, {"family": "Vaccaro", "given": "Giovanni", "initials": "G"}, {"family": "Buccheri", "given": "Sergio", "initials": "S"}, {"family": "Caramanno", "given": "Giuseppe", "initials": "G"}], "type": "comparative study", "published": "2020-09-00", "journal": {"title": "J Cardiovasc Med (Hagerstown)", "issn": "1558-2035", "volume": "21", "issue": "9", "pages": "722-724", "issn-l": null}, "abstract": null, "doi": "10.2459/JCM.0000000000001053", "pmid": "32658006", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "01244665-202009000-00019"}], "notes": [], "created": "2020-12-08T14:13:31.185Z", "modified": "2022-11-10T06:47:26.083Z"}, {"entity": "publication", "iuid": "5bd4ea9f76bc4a0e9ebb682ab140f3c2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5bd4ea9f76bc4a0e9ebb682ab140f3c2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5bd4ea9f76bc4a0e9ebb682ab140f3c2"}}, "title": "Impact of COVID-19 on Pediatric Asthma: Practice Adjustments and Disease Burden.", "authors": [{"family": "Papadopoulos", "given": "Nikolaos G", "initials": "NG"}, {"family": "Custovic", "given": "Adnan", "initials": "A"}, {"family": "Deschildre", "given": "Antoine", "initials": "A"}, {"family": "Mathioudakis", "given": "Alexander G", "initials": "AG"}, {"family": "Phipatanakul", "given": "Wanda", "initials": "W"}, {"family": "Wong", "given": "Gary", "initials": "G"}, {"family": "Xepapadaki", "given": "Paraskevi", "initials": "P"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Bacharier", "given": "Leonard", "initials": "L"}, {"family": "Bonini", "given": "Matteo", "initials": "M"}, {"family": "Castro-Rodriguez", "given": "Jose A", "initials": "JA"}, {"family": "Chen", "given": "Zhimin", "initials": "Z"}, {"family": "Craig", "given": "Timothy", "initials": "T"}, {"family": "Ducharme", "given": "Francine M", "initials": "FM"}, {"family": "El-Sayed", "given": "Zeinab Awad", "initials": "ZA"}, {"family": "Feleszko", "given": "Wojciech", "initials": "W"}, {"family": "Fiocchi", "given": "Alessandro", "initials": "A"}, {"family": "Garcia-Marcos", "given": "Luis", "initials": "L"}, {"family": "Gern", "given": "James E", "initials": "JE"}, {"family": "Goh", "given": "Anne", "initials": "A"}, {"family": "G\u00f3mez", "given": "Ren\u00e9 Maximiliano", "initials": "RM"}, {"family": "Hamelmann", "given": "Eckard H", "initials": "EH"}, {"family": "Hedlin", "given": "Gunilla", "initials": "G"}, {"family": "Hossny", "given": "Elham M", "initials": "EM"}, {"family": "Jartti", "given": "Tuomas", "initials": "T"}, {"family": "Kalayci", "given": "Omer", "initials": "O"}, {"family": "Kaplan", "given": "Alan", "initials": "A"}, {"family": "Konradsen", "given": "Jon", "initials": "J"}, {"family": "Kuna", "given": "Piotr", "initials": "P"}, {"family": "Lau", "given": "Susanne", "initials": "S"}, {"family": "Le Souef", "given": "Peter", "initials": "P"}, {"family": "Lemanske", "given": "Robert F", "initials": "RF"}, {"family": "M\u00e4kel\u00e4", "given": "Mika J", "initials": "MJ"}, {"family": "Morais-Almeida", "given": "M\u00e1rio", "initials": "M"}, {"family": "Murray", "given": "Clare", "initials": "C"}, {"family": "Nagaraju", "given": "Karthik", "initials": "K"}, {"family": "Namazova-Baranova", "given": "Leyla", "initials": "L"}, {"family": "Garcia", "given": "Antonio Nieto", "initials": "AN"}, {"family": "Yusuf", "given": "Osman M", "initials": "OM"}, {"family": "Pitrez", "given": "Paulo M C", "initials": "PMC"}, {"family": "Pohunek", "given": "Petr", "initials": "P"}, {"family": "Pozo Beltr\u00e1n", "given": "Cesar Fireth", "initials": "CF"}, {"family": "Roberts", "given": "Graham C", "initials": "GC"}, {"family": "Valiulis", "given": "Arunas", "initials": "A"}, {"family": "Zar", "given": "Heather J", "initials": "HJ"}, {"family": "Pediatric Asthma in Real Life Collaborators", "given": "", "initials": ""}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "J Allergy Clin Immunol Pract", "issn": "2213-2201", "volume": "8", "issue": "8", "pages": "2592-2599.e3", "issn-l": null}, "abstract": "It is unclear whether asthma may affect susceptibility or severity of coronavirus disease 2019 (COVID-19) in children and how pediatric asthma services worldwide have responded to the pandemic.\n\nTo describe the impact of the COVID-19 pandemic on pediatric asthma services and on disease burden in their patients.\n\nAn online survey was sent to members of the Pediatric Asthma in Real Life think tank and the World Allergy Organization Pediatric Asthma Committee. It included questions on service provision, disease burden, and the clinical course of confirmed cases of COVID-19 infection among children with asthma.\n\nNinety-one respondents, caring for an estimated population of more than 133,000 children with asthma, completed the survey. COVID-19 significantly impacted pediatric asthma services: 39% ceased physical appointments, 47% stopped accepting new patients, and 75% limited patients' visits. Consultations were almost halved to a median of 20 (interquartile range, 10-25) patients per week. Virtual clinics and helplines were launched in most centers. Better than expected disease control was reported in 20% (10%-40%) of patients, whereas control was negatively affected in only 10% (7.5%-12.5%). Adherence also appeared to increase. Only 15 confirmed cases of COVID-19 were reported among the population; the estimated incidence is not apparently different from the reports of general pediatric cohorts.\n\nChildren with asthma do not appear to be disproportionately affected by COVID-19. Outcomes may even have improved, possibly through increased adherence and/or reduced exposures. Clinical services have rapidly responded to the pandemic by limiting and replacing physical appointments with virtual encounters.", "doi": "10.1016/j.jaip.2020.06.001", "pmid": "32561497", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-2198(20)30599-7"}, {"db": "pmc", "key": "PMC7297686"}], "notes": [], "created": "2020-12-09T07:42:32.450Z", "modified": "2021-02-26T08:46:13.142Z"}, {"entity": "publication", "iuid": "4bf14407a4204ed48d96d76ba237a0ca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4bf14407a4204ed48d96d76ba237a0ca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4bf14407a4204ed48d96d76ba237a0ca"}}, "title": "How can airborne transmission of COVID-19 indoors be minimised?", "authors": [{"family": "Morawska", "given": "Lidia", "initials": "L"}, {"family": "Tang", "given": "Julian W", "initials": "JW"}, {"family": "Bahnfleth", "given": "William", "initials": "W"}, {"family": "Bluyssen", "given": "Philomena M", "initials": "PM"}, {"family": "Boerstra", "given": "Atze", "initials": "A"}, {"family": "Buonanno", "given": "Giorgio", "initials": "G"}, {"family": "Cao", "given": "Junji", "initials": "J"}, {"family": "Dancer", "given": "Stephanie", "initials": "S"}, {"family": "Floto", "given": "Andres", "initials": "A"}, {"family": "Franchimon", "given": "Francesco", "initials": "F"}, {"family": "Haworth", "given": "Charles", "initials": "C"}, {"family": "Hogeling", "given": "Jaap", "initials": "J"}, {"family": "Isaxon", "given": "Christina", "initials": "C"}, {"family": "Jimenez", "given": "Jose L", "initials": "JL"}, {"family": "Kurnitski", "given": "Jarek", "initials": "J"}, {"family": "Li", "given": "Yuguo", "initials": "Y"}, {"family": "Loomans", "given": "Marcel", "initials": "M"}, {"family": "Marks", "given": "Guy", "initials": "G"}, {"family": "Marr", "given": "Linsey C", "initials": "LC"}, {"family": "Mazzarella", "given": "Livio", "initials": "L"}, {"family": "Melikov", "given": "Arsen Krikor", "initials": "AK"}, {"family": "Miller", "given": "Shelly", "initials": "S"}, {"family": "Milton", "given": "Donald K", "initials": "DK"}, {"family": "Nazaroff", "given": "William", "initials": "W"}, {"family": "Nielsen", "given": "Peter V", "initials": "PV"}, {"family": "Noakes", "given": "Catherine", "initials": "C"}, {"family": "Peccia", "given": "Jordan", "initials": "J"}, {"family": "Querol", "given": "Xavier", "initials": "X"}, {"family": "Sekhar", "given": "Chandra", "initials": "C"}, {"family": "Sepp\u00e4nen", "given": "Olli", "initials": "O"}, {"family": "Tanabe", "given": "Shin-Ichi", "initials": "SI"}, {"family": "Tellier", "given": "Raymond", "initials": "R"}, {"family": "Tham", "given": "Kwok Wai", "initials": "KW"}, {"family": "Wargocki", "given": "Pawel", "initials": "P"}, {"family": "Wierzbicka", "given": "Aneta", "initials": "A"}, {"family": "Yao", "given": "Maosheng", "initials": "M"}], "type": "letter", "published": "2020-09-00", "journal": {"title": "Environ Int", "issn": "1873-6750", "volume": "142", "issue": null, "pages": "105832", "issn-l": "0160-4120"}, "abstract": "During the rapid rise in COVID-19 illnesses and deaths globally, and notwithstanding recommended precautions, questions are voiced about routes of transmission for this pandemic disease. Inhaling small airborne droplets is probable as a third route of infection, in addition to more widely recognized transmission via larger respiratory droplets and direct contact with infected people or contaminated surfaces. While uncertainties remain regarding the relative contributions of the different transmission pathways, we argue that existing evidence is sufficiently strong to warrant engineering controls targeting airborne transmission as part of an overall strategy to limit infection risk indoors. Appropriate building engineering controls include sufficient and effective ventilation, possibly enhanced by particle filtration and air disinfection, avoiding air recirculation and avoiding overcrowding. Often, such measures can be easily implemented and without much cost, but if only they are recognised as significant in contributing to infection control goals. We believe that the use of engineering controls in public buildings, including hospitals, shops, offices, schools, kindergartens, libraries, restaurants, cruise ships, elevators, conference rooms or public transport, in parallel with effective application of other controls (including isolation and quarantine, social distancing and hand hygiene), would be an additional important measure globally to reduce the likelihood of transmission and thereby protect healthcare workers, patients and the general public.", "doi": "10.1016/j.envint.2020.105832", "pmid": "32521345", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0160-4120(20)31787-6"}, {"db": "pmc", "key": "PMC7250761"}], "notes": [], "created": "2020-12-09T10:12:52.339Z", "modified": "2020-12-09T10:12:52.349Z"}, {"entity": "publication", "iuid": "313df89a1c90406e9b8f582c33b51de2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/313df89a1c90406e9b8f582c33b51de2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/313df89a1c90406e9b8f582c33b51de2"}}, "title": "Heparin \u2013 An old drug with multiple potential targets in Covid\u201019 therapy", "authors": [{"family": "Lindahl", "given": "Ulf", "initials": "U"}, {"family": "Li", "given": "Jin\u2010Ping", "initials": "J"}], "type": "journal-article", "published": "2020-09-00", "journal": {"title": "J Thromb Haemost", "issn": "1538-7836", "issn-l": null, "volume": "18", "issue": "9", "pages": "2422-2424"}, "abstract": null, "doi": "10.1111/jth.14898", "pmid": "32426897", "labels": {"Type: Journal article": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC7276884"}], "notes": [], "created": "2020-12-04T08:52:17.388Z", "modified": "2021-12-06T13:16:11.752Z"}, {"entity": "publication", "iuid": "fc005ee705ce4020a7b935bd77738338", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc005ee705ce4020a7b935bd77738338.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc005ee705ce4020a7b935bd77738338"}}, "title": "Editorial: Fifty Campbell systematic reviews relevant to the policy response to COVID-19.", "authors": [{"family": "Board", "given": "Campbell Editorial", "initials": "CE"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Campbell Syst Rev", "issn": "1891-1803", "volume": "16", "issue": "3", "pages": "e1107", "issn-l": null}, "abstract": null, "doi": "10.1002/cl2.1107", "pmid": "34234882", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "CL21107"}, {"db": "pmc", "key": "PMC7435573"}], "notes": [], "created": "2021-08-06T08:24:53.424Z", "modified": "2021-08-06T08:25:44.337Z"}, {"entity": "publication", "iuid": "7df03080a93f4616927e9fdeb1a5576c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7df03080a93f4616927e9fdeb1a5576c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7df03080a93f4616927e9fdeb1a5576c"}}, "title": "Does prolonged propofol sedation of mechanically ventilated COVID-19 patients contribute to critical illness myopathy?", "authors": [{"family": "L\u00f6nnqvist", "given": "Per-Arne", "initials": "PA"}, {"family": "Bell", "given": "Max", "initials": "M"}, {"family": "Karlsson", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Wiklund", "given": "Lars", "initials": "L"}, {"family": "H\u00f6glund", "given": "Anna-Stina", "initials": "AS"}, {"family": "Larsson", "given": "Lars", "initials": "L"}], "type": "letter", "published": "2020-09-00", "journal": {"title": "Br J Anaesth", "issn": "1471-6771", "volume": "125", "issue": "3", "pages": "e334-e336", "issn-l": "0007-0912"}, "abstract": null, "doi": "10.1016/j.bja.2020.05.056", "pmid": "32600801", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0007-0912(20)30440-2"}, {"db": "pmc", "key": "PMC7284264"}], "notes": [], "created": "2020-11-22T08:45:29.899Z", "modified": "2021-02-26T08:45:48.396Z"}, {"entity": "publication", "iuid": "e973ffa8e5bb4fbeae8c51c1cf412a37", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e973ffa8e5bb4fbeae8c51c1cf412a37.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e973ffa8e5bb4fbeae8c51c1cf412a37"}}, "title": "Diagnostic performance of initial blood urea nitrogen combined with D-dimer levels for predicting in-hospital mortality in COVID-19 patients.", "authors": [{"family": "Cheng", "given": "Anying", "initials": "A"}, {"family": "Hu", "given": "Liu", "initials": "L"}, {"family": "Wang", "given": "Yiru", "initials": "Y"}, {"family": "Huang", "given": "Luyan", "initials": "L"}, {"family": "Zhao", "given": "Lingxi", "initials": "L"}, {"family": "Zhang", "given": "Congcong", "initials": "C"}, {"family": "Liu", "given": "Xiyue", "initials": "X"}, {"family": "Xu", "given": "Ranran", "initials": "R"}, {"family": "Liu", "given": "Feng", "initials": "F"}, {"family": "Li", "given": "Jinping", "initials": "J"}, {"family": "Ye", "given": "Dawei", "initials": "D"}, {"family": "Wang", "given": "Tao", "initials": "T"}, {"family": "Lv", "given": "Yongman", "initials": "Y"}, {"family": "Liu", "given": "Qingquan", "initials": "Q"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Int J Antimicrob Agents", "issn": "1872-7913", "volume": "56", "issue": "3", "pages": "106110", "issn-l": null}, "abstract": "The crude mortality rate in critical pneumonia cases with coronavirus disease 2019 (COVID-19) reaches 49%. This study aimed to test whether levels of blood urea nitrogen (BUN) in combination with D-dimer were predictors of in-hospital mortality in COVID-19 patients. The clinical characteristics of 305 COVID-19 patients were analysed and were compared between the survivor and non-survivor groups. Of the 305 patients, 85 (27.9%) died and 220 (72.1%) were discharged from hospital. Compared with discharged cases, non-survivor cases were older and their BUN and D-dimer levels were significantly higher (P < 0.0001). Least absolute shrinkage and selection operator (LASSO) and multivariable Cox regression analyses identified BUN and D-dimer levels as independent risk factors for poor prognosis. Kaplan-Meier analysis showed that elevated levels of BUN and D-dimer were associated with increased mortality (log-rank, P < 0.0001). The area under the curve for BUN combined with D-dimer was 0.94 (95% CI 0.90-0.97), with a sensitivity of 85% and specificity of 91%. Based on BUN and D-dimer levels on admission, a nomogram model was developed that showed good discrimination, with a concordance index of 0.94. Together, initial BUN and D-dimer levels were associated with mortality in COVID-19 patients. The combination of BUN \u2265 4.6 mmol/L and D-dimer \u2265 0.845 \u03bcg/mL appears to identify patients at high risk of in-hospital mortality, therefore it may prove to be a powerful risk assessment tool for severe COVID-19 patients.", "doi": "10.1016/j.ijantimicag.2020.106110", "pmid": "32712332", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0924-8579(20)30293-4"}, {"db": "pmc", "key": "PMC7377803"}], "notes": [], "created": "2020-12-07T16:15:03.755Z", "modified": "2021-02-26T08:45:48.829Z"}, {"entity": "publication", "iuid": "da6866a15f904121ace0557c7923f7b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/da6866a15f904121ace0557c7923f7b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/da6866a15f904121ace0557c7923f7b9"}}, "title": "Developing thinking around mental health science: the example of intrusive, emotional mental imagery after psychological trauma.", "authors": [{"family": "Singh", "given": "Laura", "initials": "L"}, {"family": "Espinosa", "given": "Lisa", "initials": "L"}, {"family": "Ji", "given": "Julie L", "initials": "JL"}, {"family": "Moulds", "given": "Michelle L", "initials": "ML"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Cogn Neuropsychiatry", "issn": "1464-0619", "volume": "25", "issue": "5", "pages": "348-363", "issn-l": "1354-6805"}, "abstract": "One route to advancing psychological treatments is to harness mental health science, a multidisciplinary approach including individuals with lived experience and end users (e.g., Holmes, E. A., Craske, M. G., & Graybiel, A. M. (2014). Psychological treatments: A call for mental-health science. Nature, 511(7509), 287-289. doi:10.1038/511287a). While early days, we here illustrate a line of research explored by our group-intrusive imagery-based memories after trauma.\n\nWe illustrate three possible approaches through which mental health science may stimulate thinking around psychological treatment innovation. First, focusing on single/specific target symptoms rather than full, multifaceted psychiatric diagnoses (e.g., intrusive trauma memories rather than all of posttraumatic stress disorder). Second, investigating mechanisms that can be modified in treatment (treatment mechanisms), rather than those which cannot (e.g., processes only linked to aetiology). Finally, exploring novel ways of delivering psychological treatment (peer-/self-administration), given the prevalence of mental health problems globally, and the corresponding need for effective interventions that can be delivered at scale and remotely for example at times of crisis (e.g., current COVID-19 pandemic).\n\nThese three approaches suggest options for potential innovative avenues through which mental health science may be harnessed to recouple basic and applied research and transform treatment development.", "doi": "10.1080/13546805.2020.1804845", "pmid": "32847486", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-22T09:55:45.251Z", "modified": "2020-11-30T08:36:36.440Z"}, {"entity": "publication", "iuid": "d9bdeca3f991438e9dec081348aa9da9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d9bdeca3f991438e9dec081348aa9da9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d9bdeca3f991438e9dec081348aa9da9"}}, "title": "Coagulation disorder in COVID-19.", "authors": [{"family": "Kander", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Lancet Haematol", "issn": "2352-3026", "volume": "7", "issue": "9", "pages": "e630-e632", "issn-l": null}, "abstract": null, "doi": "10.1016/S2352-3026(20)30218-0", "pmid": "32659213", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2352-3026(20)30218-0"}, {"db": "pmc", "key": "PMC7351400"}], "notes": [], "created": "2020-12-08T14:11:45.590Z", "modified": "2020-12-08T14:11:45.611Z"}, {"entity": "publication", "iuid": "c232619d7e704e339f0fd02748324289", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c232619d7e704e339f0fd02748324289.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c232619d7e704e339f0fd02748324289"}}, "title": "Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke: The Global COVID-19 Stroke Registry.", "authors": [{"family": "Ntaios", "given": "George", "initials": "G"}, {"family": "Michel", "given": "Patrik", "initials": "P"}, {"family": "Georgiopoulos", "given": "Georgios", "initials": "G"}, {"family": "Guo", "given": "Yutao", "initials": "Y"}, {"family": "Li", "given": "Wencheng", "initials": "W"}, {"family": "Xiong", "given": "Jing", "initials": "J"}, {"family": "Calleja", "given": "Patricia", "initials": "P"}, {"family": "Ostos", "given": "Fernando", "initials": "F"}, {"family": "Gonz\u00e1lez-Ortega", "given": "Guillermo", "initials": "G"}, {"family": "Fuentes", "given": "Blanca", "initials": "B"}, {"family": "Alonso de Leci\u00f1ana", "given": "Mar\u00eda", "initials": "M"}, {"family": "D\u00edez-Tejedor", "given": "Exuperio", "initials": "E"}, {"family": "Garc\u00eda-Madrona", "given": "Sebastian", "initials": "S"}, {"family": "Masjuan", "given": "Jaime", "initials": "J"}, {"family": "DeFelipe", "given": "Alicia", "initials": "A"}, {"family": "Turc", "given": "Guillaume", "initials": "G"}, {"family": "Gon\u00e7alves", "given": "Bruno", "initials": "B"}, {"family": "Domigo", "given": "Valerie", "initials": "V"}, {"family": "Dan", "given": "Gheorghe-Andrei", "initials": "GA"}, {"family": "Vezeteu", "given": "Roxana", "initials": "R"}, {"family": "Christensen", "given": "Hanne", "initials": "H"}, {"family": "Christensen", "given": "Louisa Marguerite", "initials": "LM"}, {"family": "Meden", "given": "Per", "initials": "P"}, {"family": "Hajdarevic", "given": "Lejla", "initials": "L"}, {"family": "Rodriguez-Lopez", "given": "Angela", "initials": "A"}, {"family": "D\u00edaz-Otero", "given": "Fernando", "initials": "F"}, {"family": "Garc\u00eda-Pastor", "given": "Andr\u00e9s", "initials": "A"}, {"family": "Gil-Nu\u00f1ez", "given": "Antonio", "initials": "A"}, {"family": "Maslias", "given": "Errikos", "initials": "E"}, {"family": "Strambo", "given": "Davide", "initials": "D"}, {"family": "Werring", "given": "David J", "initials": "DJ"}, {"family": "Chandratheva", "given": "Arvind", "initials": "A"}, {"family": "Benjamin", "given": "Laura", "initials": "L"}, {"family": "Simister", "given": "Robert", "initials": "R"}, {"family": "Perry", "given": "Richard", "initials": "R"}, {"family": "Beyrouti", "given": "Rahma", "initials": "R"}, {"family": "Jabbour", "given": "Pascal", "initials": "P"}, {"family": "Sweid", "given": "Ahmad", "initials": "A"}, {"family": "Tjoumakaris", "given": "Stavropoula", "initials": "S"}, {"family": "Cuadrado-Godia", "given": "Elisa", "initials": "E"}, {"family": "Campello", "given": "Ana Rodr\u00edguez", "initials": "AR"}, {"family": "Roquer", "given": "Jaume", "initials": "J"}, {"family": "Moreira", "given": "Tiago", "initials": "T"}, {"family": "Mazya", "given": "Michael V", "initials": "MV"}, {"family": "Bandini", "given": "Fabio", "initials": "F"}, {"family": "Matz", "given": "Karl", "initials": "K"}, {"family": "Iversen", "given": "Helle K", "initials": "HK"}, {"family": "Gonz\u00e1lez-Duarte", "given": "Alejandra", "initials": "A"}, {"family": "Tiu", "given": "Cristina", "initials": "C"}, {"family": "Ferrari", "given": "Julia", "initials": "J"}, {"family": "Vosko", "given": "Milan R", "initials": "MR"}, {"family": "Salzer", "given": "Helmut J F", "initials": "HJF"}, {"family": "Lamprecht", "given": "Bernd", "initials": "B"}, {"family": "D\u00fcnser", "given": "Martin W", "initials": "MW"}, {"family": "Cereda", "given": "Carlo W", "initials": "CW"}, {"family": "Quintero", "given": "\u00c1ngel Basilio Corredor", "initials": "\u00c1BC"}, {"family": "Korompoki", "given": "Eleni", "initials": "E"}, {"family": "Soriano-Navarro", "given": "Eduardo", "initials": "E"}, {"family": "Soto-Ram\u00edrez", "given": "Luis Enrique", "initials": "LE"}, {"family": "Casta\u00f1eda-M\u00e9ndez", "given": "Paulo F", "initials": "PF"}, {"family": "Bay-Sansores", "given": "Daniela", "initials": "D"}, {"family": "Arauz", "given": "Antonio", "initials": "A"}, {"family": "Cano-Nigenda", "given": "Vanessa", "initials": "V"}, {"family": "Kristoffersen", "given": "Espen Saxhaug", "initials": "ES"}, {"family": "Tiainen", "given": "Marjaana", "initials": "M"}, {"family": "Strbian", "given": "Daniel", "initials": "D"}, {"family": "Putaala", "given": "Jukka", "initials": "J"}, {"family": "Lip", "given": "Gregory Y H", "initials": "GYH"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Stroke", "issn": "1524-4628", "volume": "51", "issue": "9", "pages": "e254-e258", "issn-l": null}, "abstract": "Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that severe strokes are typically associated with poor prognosis and can be very efficiently treated with recanalization techniques, confirmation of this putative association is urgently warranted in a large representative patient cohort to alert stroke clinicians, and inform pre- and in-hospital acute stroke patient pathways. We pooled all consecutive patients hospitalized with laboratory-confirmed COVID-19 and acute ischemic stroke in 28 sites from 16 countries. To assess whether stroke severity and outcomes (assessed at discharge or at the latest assessment for those patients still hospitalized) in patients with acute ischemic stroke are different between patients with COVID-19 and non-COVID-19, we performed 1:1 propensity score matching analyses of our COVID-19 patients with non-COVID-19 patients registered in the Acute Stroke Registry and Analysis of Lausanne Registry between 2003 and 2019. Between January 27, 2020, and May 19, 2020, 174 patients (median age 71.2 years; 37.9% females) with COVID-19 and acute ischemic stroke were hospitalized (median of 12 patients per site). The median National Institutes of Health Stroke Scale was 10 (interquartile range [IQR], 4-18). In the 1:1 matched sample of 336 patients with COVID-19 and non-COVID-19, the median National Institutes of Health Stroke Scale was higher in patients with COVID-19 (10 [IQR, 4-18] versus 6 [IQR, 3-14]), P=0.03; (odds ratio, 1.69 [95% CI, 1.08-2.65] for higher National Institutes of Health Stroke Scale score). There were 48 (27.6%) deaths, of which 22 were attributed to COVID-19 and 26 to stroke. Among 96 survivors with available information about disability status, 49 (51%) had severe disability at discharge. In the propensity score-matched population (n=330), patients with COVID-19 had higher risk for severe disability (median mRS 4 [IQR, 2-6] versus 2 [IQR, 1-4], P<0.001) and death (odds ratio, 4.3 [95% CI, 2.22-8.30]) compared with patients without COVID-19. Our findings suggest that COVID-19 associated ischemic strokes are more severe with worse functional outcome and higher mortality than non-COVID-19 ischemic strokes.", "doi": "10.1161/STROKEAHA.120.031208", "pmid": "32787707", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7359900"}], "notes": [], "created": "2020-12-07T13:28:17.725Z", "modified": "2020-12-07T13:28:17.748Z"}, {"entity": "publication", "iuid": "cd3b5e14785c493a88046a386f265e86", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cd3b5e14785c493a88046a386f265e86.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cd3b5e14785c493a88046a386f265e86"}}, "title": "COVID-19: guidance on palliative care from a European Respiratory Society international task force.", "authors": [{"family": "Janssen", "given": "Daisy J A", "initials": "DJA"}, {"family": "Ekstr\u00f6m", "given": "Magnus", "initials": "M"}, {"family": "Currow", "given": "David C", "initials": "DC"}, {"family": "Johnson", "given": "Miriam J", "initials": "MJ"}, {"family": "Maddocks", "given": "Matthew", "initials": "M"}, {"family": "Simonds", "given": "Anita K", "initials": "AK"}, {"family": "Tonia", "given": "Thomy", "initials": "T"}, {"family": "Marsaa", "given": "Kristoffer", "initials": "K"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "volume": "56", "issue": "3", "issn-l": "0903-1936"}, "abstract": "Many people are dying from coronavirus disease 2019 (COVID-19), but consensus guidance on palliative care in COVID-19 is lacking. This new life-threatening disease has put healthcare systems under pressure, with the increased need of palliative care provided to many patients by clinicians who have limited prior experience in this field. Therefore, we aimed to make consensus recommendations for palliative care for patients with COVID-19 using the Convergence of Opinion on Recommendations and Evidence (CORE) process.\n\nWe invited 90 international experts to complete an online survey including stating their agreement, or not, with 14 potential recommendations. At least 70% agreement on directionality was needed to provide consensus recommendations. If consensus was not achieved on the first round, a second round was conducted.\n\n68 (75.6%) experts responded in the first round. Most participants were experts in palliative care, respiratory medicine or critical care medicine. In the first round, consensus was achieved on 13 recommendations based upon indirect evidence and clinical experience. In the second round, 58 (85.3%) out of 68 of the first-round experts responded, resulting in consensus for the 14th recommendation.\n\nThis multi-national task force provides consensus recommendations for palliative care for patients with COVID-19 concerning: advance care planning; (pharmacological) palliative treatment of breathlessness; clinician-patient communication; remote clinician-family communication; palliative care involvement in patients with serious COVID-19; spiritual care; psychosocial care; and bereavement care. Future studies are needed to generate empirical evidence for these recommendations.", "doi": "10.1183/13993003.02583-2020", "pmid": "32675211", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "13993003.02583-2020"}, {"db": "pmc", "key": "PMC7366176"}], "notes": [], "created": "2020-12-07T16:35:43.217Z", "modified": "2020-12-07T16:35:43.229Z"}, {"entity": "publication", "iuid": "b28bfa553b78495dabbac185e24c9ec3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b28bfa553b78495dabbac185e24c9ec3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b28bfa553b78495dabbac185e24c9ec3"}}, "title": "COVID-19 in people with multiple sclerosis: A global data sharing initiative.", "authors": [{"family": "Peeters", "given": "Liesbet M", "initials": "LM", "orcid": "0000-0002-6066-3899", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d3fd89e85e4e4368b68b086da3e8cae0.json"}}, {"family": "Parciak", "given": "Tina", "initials": "T"}, {"family": "Walton", "given": "Clare", "initials": "C"}, {"family": "Geys", "given": "Lotte", "initials": "L"}, {"family": "Moreau", "given": "Yves", "initials": "Y"}, {"family": "De Brouwer", "given": "Edward", "initials": "E"}, {"family": "Raimondi", "given": "Daniele", "initials": "D"}, {"family": "Pirmani", "given": "Ashkan", "initials": "A", "orcid": "0000-0003-4549-1002", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d72bbbd407ef4f5387e6653e68e127fc.json"}}, {"family": "Kalincik", "given": "Tomas", "initials": "T"}, {"family": "Edan", "given": "Gilles", "initials": "G"}, {"family": "Simpson-Yap", "given": "Steve", "initials": "S", "orcid": "0000-0001-6521-3056", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/845cbea3a2f64b9f880a43d6cc8cdb09.json"}}, {"family": "De Raedt", "given": "Luc", "initials": "L"}, {"family": "Dauxais", "given": "Yann", "initials": "Y"}, {"family": "Gautrais", "given": "Cl\u00e9ment", "initials": "C", "orcid": "0000-0001-8486-9616", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ac26ecdf30114e889dca0e02f3e1588d.json"}}, {"family": "Rodrigues", "given": "Paulo R", "initials": "PR"}, {"family": "McKenna", "given": "Landon", "initials": "L"}, {"family": "Lazovski", "given": "Nikola", "initials": "N"}, {"family": "Hillert", "given": "Jan", "initials": "J"}, {"family": "Forsberg", "given": "Lars", "initials": "L"}, {"family": "Spelman", "given": "Tim", "initials": "T", "orcid": "0000-0001-9204-3216", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ab24deed7243491387cb220c2a0c8606.json"}}, {"family": "McBurney", "given": "Robert", "initials": "R"}, {"family": "Schmidt", "given": "Hollie", "initials": "H"}, {"family": "Bergmann", "given": "Arnfin", "initials": "A"}, {"family": "Braune", "given": "Stefan", "initials": "S"}, {"family": "Stahmann", "given": "Alexander", "initials": "A"}, {"family": "Middleton", "given": "Rodden", "initials": "R", "orcid": "0000-0002-2130-4420", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7adf9663f3ea4db7b2bfc70b724ad309.json"}}, {"family": "Salter", "given": "Amber", "initials": "A", "orcid": "0000-0002-1088-110X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e108ab0c847c4d5b8e66af7cfb6619ec.json"}}, {"family": "Bebo", "given": "Bruce F", "initials": "BF"}, {"family": "Rojas", "given": "Juan I", "initials": "JI"}, {"family": "van der Walt", "given": "Anneke", "initials": "A", "orcid": "0000-0002-4278-7003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4636e8ba06d94593929e1c30619cc500.json"}}, {"family": "Butzkueven", "given": "Helmut", "initials": "H"}, {"family": "van der Mei", "given": "Ingrid", "initials": "I"}, {"family": "Ivanov", "given": "Rumen", "initials": "R"}, {"family": "Hellwig", "given": "Kerstin", "initials": "K"}, {"family": "Sciascia do Olival", "given": "Guilherme", "initials": "G"}, {"family": "Cohen", "given": "Jeffrey A", "initials": "JA", "orcid": "0000-0001-9245-9772", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7c2d691831eb430ea38710e0bec3ad61.json"}}, {"family": "Van Hecke", "given": "Wim", "initials": "W"}, {"family": "Dobson", "given": "Ruth", "initials": "R", "orcid": "0000-0002-2993-585X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b95a061e61124498ba6a11f27e0105dd.json"}}, {"family": "Magyari", "given": "Melinda", "initials": "M"}, {"family": "Brum", "given": "Doralina Guimar\u00e3es", "initials": "DG"}, {"family": "Alonso", "given": "Ricardo", "initials": "R"}, {"family": "Nicholas", "given": "Richard", "initials": "R"}, {"family": "Bauer", "given": "Johana", "initials": "J"}, {"family": "Chertcoff", "given": "Anibal", "initials": "A"}, {"family": "de S\u00e8ze", "given": "J\u00e9r\u00f4me", "initials": "J"}, {"family": "Louapre", "given": "C\u00e9line", "initials": "C"}, {"family": "Comi", "given": "Giancarlo", "initials": "G"}, {"family": "Rijke", "given": "Nick", "initials": "N"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Mult Scler", "issn": "1477-0970", "volume": "26", "issue": "10", "pages": "1157-1162", "issn-l": null}, "abstract": "We need high-quality data to assess the determinants for COVID-19 severity in people with MS (PwMS). Several studies have recently emerged but there is great benefit in aligning data collection efforts at a global scale.\n\nOur mission is to scale-up COVID-19 data collection efforts and provide the MS community with data-driven insights as soon as possible.\n\nNumerous stakeholders were brought together. Small dedicated interdisciplinary task forces were created to speed-up the formulation of the study design and work plan. First step was to agree upon a COVID-19 MS core data set. Second, we worked on providing a user-friendly and rapid pipeline to share COVID-19 data at a global scale.\n\nThe COVID-19 MS core data set was agreed within 48 hours. To date, 23 data collection partners are involved and the first data imports have been performed successfully. Data processing and analysis is an on-going process.\n\nWe reached a consensus on a core data set and established data sharing processes with multiple partners to address an urgent need for information to guide clinical practice. First results show that partners are motivated to share data to attain the ultimate joint goal: better understand the effect of COVID-19 in PwMS.", "doi": "10.1177/1352458520941485", "pmid": "32662757", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7361123"}], "notes": [], "created": "2020-12-08T10:43:30.100Z", "modified": "2023-06-19T14:42:04.913Z"}, {"entity": "publication", "iuid": "2d4895ba0d5e42d19aad6ebf4d7163d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d4895ba0d5e42d19aad6ebf4d7163d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d4895ba0d5e42d19aad6ebf4d7163d5"}}, "title": "Age, Inflammation, and Disease Location Are Critical Determinants of Intestinal Expression of SARS-CoV-2 Receptor ACE2 and TMPRSS2 in Inflammatory Bowel Disease.", "authors": [{"family": "Nowak", "given": "Jan Krzysztof", "initials": "JK"}, {"family": "Lindstr\u00f8m", "given": "Jonas Christoffer", "initials": "JC"}, {"family": "Kalla", "given": "Rahul", "initials": "R"}, {"family": "Ricanek", "given": "Petr", "initials": "P"}, {"family": "Halfvarson", "given": "Jonas", "initials": "J"}, {"family": "Satsangi", "given": "Jack", "initials": "J"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Gastroenterology", "issn": "1528-0012", "issn-l": null, "volume": "159", "issue": "3", "pages": "1151-1154.e2"}, "abstract": null, "doi": "10.1053/j.gastro.2020.05.030", "pmid": "32413354", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0016-5085(20)30653-3"}, {"db": "pmc", "key": "PMC7217073"}], "notes": [], "created": "2020-12-10T08:52:09.765Z", "modified": "2021-02-26T08:45:47.984Z"}, {"entity": "publication", "iuid": "b7ed4f4a0b3d4a3da337cd6166d65ef7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b7ed4f4a0b3d4a3da337cd6166d65ef7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b7ed4f4a0b3d4a3da337cd6166d65ef7"}}, "title": "A snapshot of European neurosurgery December 2019 vs. March 2020: just before and during the Covid-19 pandemic.", "authors": [{"family": "Mathiesen", "given": "T", "initials": "T"}, {"family": "Arraez", "given": "M", "initials": "M"}, {"family": "Asser", "given": "T", "initials": "T"}, {"family": "Balak", "given": "N", "initials": "N"}, {"family": "Barazi", "given": "S", "initials": "S"}, {"family": "Bernucci", "given": "C", "initials": "C"}, {"family": "Bolger", "given": "C", "initials": "C"}, {"family": "Broekman", "given": "M L D", "initials": "MLD"}, {"family": "Demetriades", "given": "A K", "initials": "AK"}, {"family": "Feldman", "given": "Z", "initials": "Z"}, {"family": "Fontanella", "given": "M M", "initials": "MM"}, {"family": "Foroglou", "given": "N", "initials": "N"}, {"family": "Lafuente", "given": "J", "initials": "J"}, {"family": "Maier", "given": "A D", "initials": "AD"}, {"family": "Meyer", "given": "B", "initials": "B"}, {"family": "Niemel\u00e4", "given": "M", "initials": "M"}, {"family": "Roche", "given": "P H", "initials": "PH"}, {"family": "Sala", "given": "F", "initials": "F"}, {"family": "Sampr\u00f3n", "given": "N", "initials": "N"}, {"family": "Sandvik", "given": "U", "initials": "U"}, {"family": "Schaller", "given": "K", "initials": "K"}, {"family": "Thome", "given": "C", "initials": "C"}, {"family": "Thys", "given": "M", "initials": "M"}, {"family": "Tisell", "given": "M", "initials": "M"}, {"family": "Vajkoczy", "given": "P", "initials": "P"}, {"family": "Visocchi", "given": "M", "initials": "M"}, {"family": "EANS Ethico-legal committee", "given": "", "initials": ""}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Acta Neurochir (Wien)", "issn": "0942-0940", "volume": "162", "issue": "9", "pages": "2221-2233", "issn-l": "0001-6268"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or Covid-19), which began as an epidemic in China and spread globally as a pandemic, has necessitated resource management to meet emergency needs of Covid-19 patients and other emergent cases. We have conducted a survey to analyze caseload and measures to adapt indications for a perception of crisis.\n\nWe constructed a questionnaire to survey a snapshot of neurosurgical activity, resources, and indications during 1 week with usual activity in December 2019 and 1 week during SARS-CoV-2 pandemic in March 2020. The questionnaire was sent to 34 neurosurgical departments in Europe; 25 departments returned responses within 5 days.\n\nWe found unexpectedly large differences in resources and indications already before the pandemic. Differences were also large in how much practice and resources changed during the pandemic. Neurosurgical beds and neuro-intensive care beds were significantly decreased from December 2019 to March 2020. The utilization of resources decreased via less demand for care of brain injuries and subarachnoid hemorrhage, postponing surgery and changed surgical indications as a method of rationing resources. Twenty departments (80%) reduced activity extensively, and the same proportion stated that they were no longer able to provide care according to legitimate medical needs.\n\nNeurosurgical centers responded swiftly and effectively to a sudden decrease of neurosurgical capacity due to relocation of resources to pandemic care. The pandemic led to rationing of neurosurgical care in 80% of responding centers. We saw a relation between resources before the pandemic and ability to uphold neurosurgical services. The observation of extensive differences of available beds provided an opportunity to show how resources that had been restricted already under normal conditions translated to rationing of care that may not be acceptable to the public of seemingly affluent European countries.", "doi": "10.1007/s00701-020-04482-8", "pmid": "32642834", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00701-020-04482-8"}, {"db": "pmc", "key": "PMC7343382"}], "notes": [], "created": "2020-12-08T14:30:29.037Z", "modified": "2020-12-08T14:30:29.046Z"}, {"entity": "publication", "iuid": "8e1aad5a6c4d4b588eb1de6f6cb85a2b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8e1aad5a6c4d4b588eb1de6f6cb85a2b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8e1aad5a6c4d4b588eb1de6f6cb85a2b"}}, "title": "A critical review of the pathophysiology of thrombotic complications and clinical practice recommendations for thromboprophylaxis in pregnant patients with COVID-19.", "authors": [{"family": "D'Souza", "given": "Rohan", "initials": "R"}, {"family": "Malham\u00e9", "given": "Isabelle", "initials": "I"}, {"family": "Teshler", "given": "Lizabeth", "initials": "L"}, {"family": "Acharya", "given": "Ganesh", "initials": "G"}, {"family": "Hunt", "given": "Beverley J", "initials": "BJ"}, {"family": "McLintock", "given": "Claire", "initials": "C"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "9", "pages": "1110-1120", "issn-l": "0001-6349"}, "abstract": "Those who are infected with Severe Acute Respiratory Syndrome-related CoronaVirus-2 are theoretically at increased risk of venous thromboembolism during self-isolation if they have reduced mobility or are dehydrated. Should patients develop coronavirus disease (COVID-19) pneumonia requiring hospital admission for treatment of hypoxia, the risk for thromboembolic complications increases greatly. These thromboembolic events are the result of at least two distinct mechanisms - microvascular thrombosis in the pulmonary system (immunothrombosis) and hospital-associated venous thromboembolism. Since pregnancy is a prothrombotic state, there is concern regarding the potentially increased risk of thrombotic complications among pregnant women with COVID-19. To date, however, pregnant women do not appear to have a substantially increased risk of thrombotic complications related to COVID-19. Nevertheless, several organizations have vigilantly issued pregnancy-specific guidelines for thromboprophylaxis in COVID-19. Discrepancies between these guidelines reflect the altruistic wish to protect patients and lack of high-quality evidence available to inform clinical practice. Low molecular weight heparin (LMWH) is the drug of choice for thromboprophylaxis in pregnant women with COVID-19. However, its utility in non-pregnant patients is only established against venous thromboembolism, as LMWH may have little or no effect on immunothrombosis. Decisions about initiation and duration of prophylactic anticoagulation in the context of pregnancy and COVID-19 must take into consideration disease severity, outpatient vs inpatient status, temporal relation between disease occurrence and timing of childbirth, and the underlying prothrombotic risk conferred by additional comorbidities. There is currently no evidence to recommend the use of intermediate or therapeutic doses of LMWH in thromboprophylaxis, which may increase bleeding risk without reducing thrombotic risk in pregnant patients with COVID-19. Likewise, there is no evidence to comment on the role of low-dose aspirin in thromboprophylaxis or of anti-cytokine and antiviral agents in preventing immunothrombosis. These unanswered questions are being studied within the context of clinical trials.", "doi": "10.1111/aogs.13962", "pmid": "32678949", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7404828"}], "notes": [], "created": "2020-11-26T12:14:06.219Z", "modified": "2020-11-30T08:45:13.568Z"}, {"entity": "publication", "iuid": "aeeb2de8be7c4b6dacb136d427561a49", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aeeb2de8be7c4b6dacb136d427561a49.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aeeb2de8be7c4b6dacb136d427561a49"}}, "title": "The SARS-CoV-2 N Protein Is a Good Component in a Vaccine.", "authors": [{"family": "Ahl\u00e9n", "given": "Gustaf", "initials": "G"}, {"family": "Frelin", "given": "Lars", "initials": "L"}, {"family": "Nikouyan", "given": "Negin", "initials": "N"}, {"family": "Weber", "given": "Friedemann", "initials": "F"}, {"family": "H\u00f6glund", "given": "Urban", "initials": "U"}, {"family": "Larsson", "given": "Olivia", "initials": "O"}, {"family": "Westman", "given": "Marie", "initials": "M"}, {"family": "Tuvesson", "given": "Ola", "initials": "O"}, {"family": "Gidlund", "given": "Eva-Karin", "initials": "EK"}, {"family": "Cadossi", "given": "Matteo", "initials": "M"}, {"family": "Appelberg", "given": "Sofia", "initials": "S"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "S\u00e4llberg", "given": "Matti", "initials": "M"}, {"family": "OPENCORONA Consortium", "given": "", "initials": ""}], "type": "letter", "published": "2020-08-31", "journal": {"title": "J Virol", "issn": "0022-538X", "volume": "94", "issue": "18", "issn-l": null}, "abstract": null, "doi": "10.1128/JVI.01279-20", "pmid": "32661140", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "JVI.01279-20"}, {"db": "pmc", "key": "PMC7459553"}], "notes": [], "created": "2020-11-19T19:35:23.241Z", "modified": "2020-12-08T10:44:08.917Z"}, {"entity": "publication", "iuid": "d813fde6181648e4abcc5ebc6d6c9cd6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d813fde6181648e4abcc5ebc6d6c9cd6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d813fde6181648e4abcc5ebc6d6c9cd6"}}, "title": "Screening for natural and derived bio-active compounds in preclinical and clinical studies: One of the frontlines of fighting the coronaviruses pandemic.", "authors": [{"family": "Khalifa", "given": "Shaden A M", "initials": "SAM"}, {"family": "Yosri", "given": "Nermeen", "initials": "N"}, {"family": "El-Mallah", "given": "Mohamed F", "initials": "MF"}, {"family": "Ghonaim", "given": "Reem", "initials": "R"}, {"family": "Guo", "given": "Zhiming", "initials": "Z"}, {"family": "Musharraf", "given": "Syed Ghulam", "initials": "SG"}, {"family": "Du", "given": "Ming", "initials": "M"}, {"family": "Khatib", "given": "Alfi", "initials": "A"}, {"family": "Xiao", "given": "Jianbo", "initials": "J"}, {"family": "Saeed", "given": "Aamer", "initials": "A"}, {"family": "El-Seedi", "given": "Haged H R", "initials": "HHR"}, {"family": "Zhao", "given": "Chao", "initials": "C"}, {"family": "Efferth", "given": "Thomas", "initials": "T"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}], "type": "journal article", "published": "2020-08-29", "journal": {"title": "Phytomedicine", "issn": "1618-095X", "volume": null, "issue": null, "pages": "153311", "issn-l": "0944-7113"}, "abstract": "Starting December 2019, mankind faced an unprecedented enemy, the COVID-19 virus. The world convened in international efforts, experiences and technologies in order to fight the emerging pandemic. Isolation, hygiene measure, diagnosis, and treatment are the most efficient ways of prevention and intervention nowadays. The health organizations and global care systems screened the available resources and offered recommendations of approved and proposed medications. However, the search for a specific selective therapy or vaccine against COVID-19 remains a challenge.\n\nA literature search was performed for the screening of natural and derived bio-active compounds which showed potent antiviral activity against coronaviruses using published articles, patents, clinical trials website (https://clinicaltrials.gov/) and web databases (PubMed, SCI Finder, Science Direct, and Google Scholar).\n\nThrough the screening for natural products with antiviral activities against different types of the human coronavirus, extracts of Lycoris radiata (L'H\u00e9r.), Gentiana scabra Bunge, Dioscorea batatas Decne., Cassia tora L., Taxillus chinensis (DC.), Cibotium barometz L. and Echinacea purpurea L. showed a promising effect against SARS-CoV. Out of the listed compound Lycorine, emetine dihydrochloride hydrate, pristimerin, harmine, conessine, berbamine, 4`-hydroxychalcone, papaverine, mycophenolic acid, mycophenolate mofetil, monensin sodium, cycloheximide, oligomycin and valinomycin show potent activity against human coronaviruses. Additionally, it is worth noting that some compounds have already moved into clinical trials for their activity against COVID-19 including fingolimod, methylprednisolone, chloroquine, tetrandrine and tocilizumab.\n\nNatural compounds and their derivatives could be used for developing potent therapeutics with significant activity against SARS-COV-2, providing a promising frontline in the fighting against COVID-19.", "doi": "10.1016/j.phymed.2020.153311", "pmid": "33067112", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0944-7113(20)30143-4"}, {"db": "pmc", "key": "PMC7455571"}], "notes": [], "created": "2020-11-26T12:33:13.706Z", "modified": "2020-11-27T11:51:36.346Z"}, {"entity": "publication", "iuid": "d1d9102f7bcc4023a72f702c84f034bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d1d9102f7bcc4023a72f702c84f034bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d1d9102f7bcc4023a72f702c84f034bd"}}, "title": "SARS-CoV-2 RNA in serum as predictor of severe outcome in COVID-19: a retrospective cohort study.", "authors": [{"family": "Hagman", "given": "Karl", "initials": "K"}, {"family": "Hedenstierna", "given": "Magnus", "initials": "M"}, {"family": "Gille-Johnson", "given": "Patrik", "initials": "P"}, {"family": "Hammas", "given": "Berit", "initials": "B"}, {"family": "Grabbe", "given": "Malin", "initials": "M"}, {"family": "Dillner", "given": "Joakim", "initials": "J"}, {"family": "Ursing", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2020-08-28", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "issn-l": "1058-4838", "volume": null, "issue": null, "pages": null}, "abstract": "Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes Coronavirus disease 2019 (COVID-19). This study aimed to determine if SARS-CoV-2 RNA in serum at admission correlated with clinical outcome in COVID-19.\r\n\r\nCOVID-19 patients admitted to the Infectious Diseases department of a tertiary level Swedish hospital, and sampled for SARS-CoV-2 RNA in serum at admission, April 10 to June 30 2020 were included in a cohort. Primary outcomes were day 28 all-cause mortality and progress to critical disease.\r\n\r\nThe cohort (N=167) consisted of 106 SARS-CoV-2 RNA serum negative and 61 positive patients. Median sampling time for initial SARS-CoV-2 in serum was 1 (IQR 1-2) day after admission corresponding to day 10 (IQR 8-12) after symptom onset. Median ages were 53 (IQR 44-67) and 63 (IQR 52-74) years for the PCR-negative and positive patients, respectively. In the serum PCR negative and positive groups 3/106 and 15/61 patients died, respectively.The hazard ratios for critical disease and all-cause mortality were 7.2 (95% CI 3.0-17) and 8.6 (95% CI 2.4-30), respectively for patients that were serum PCR positive compared to serum PCR negative.Conclusion: SARS-CoV-2 RNA in serum at hospital admission indicates a high-risk of progression to critical disease and death.", "doi": "10.1093/cid/ciaa1285", "pmid": "32856036", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "5898271"}, {"db": "pmc", "key": "PMC7499508"}], "notes": [], "created": "2020-12-04T08:59:08.585Z", "modified": "2021-02-26T08:45:48.744Z"}, {"entity": "publication", "iuid": "1edfbec48fb445bd9b215700435d8ded", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1edfbec48fb445bd9b215700435d8ded.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1edfbec48fb445bd9b215700435d8ded"}}, "title": "A case-report of widespread pulmonary embolism in a middle-aged male seven weeks after asymptomatic suspected COVID 19 infection.", "authors": [{"family": "Beckman", "given": "Mats", "initials": "M"}, {"family": "Nyr\u00e9n", "given": "Sven", "initials": "S"}, {"family": "Kistner", "given": "Anna", "initials": "A"}], "type": "case reports", "published": "2020-08-28", "journal": {"title": "Thromb J", "issn": "1477-9560", "volume": "18", "issue": null, "pages": "19", "issn-l": null}, "abstract": "Pulmonary embolism (PE) is seen in high frequency in hospital-treated patients with Covid-19. We present a case of suspected Covid-19 with long-term dyspnea and widespread PE.\n\nA 51- year old male, with no prior medical history, no medication, and non-smoker arrived at the emergency department with exercise induced dyspnea during 4-5 weeks and for the last 48 h dyspnea at rest. Seven weeks before hospitalization, he felt difficulties taking deep breaths for some days but no other symptoms. Oxygen saturation at rest was 93%. Troponin T was 1200 mg/L (ref < 15 mg/L). CT angiography revealed widespread bilateral segmental pulmonary embolism. Additional findings were ground glass opacities that could match Covid-19. The patient tested negative for SARS -CoV-2. Full dose tinzaparin was given for 2 days in hospital, followed by apixaban for 6 months. Recovery has been uneventful so far.\n\nLong-term breathing difficulties might be relatively common after non-hospitalized symptomatic Covid-19. The frequency of PE in this group is unknown. We report a case of suspected covid-19 with widespread PE and a long history of dyspnea but no other symptoms. In our case slight hypoxia and laboratory testing indicated significant disease, which was proven with contrast angiography. This case shows that PE is a differential diagnosis in non-hospitalized symptomatic Covid-19 with persisting breathing problems.", "doi": "10.1186/s12959-020-00235-w", "pmid": "32868974", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "235"}, {"db": "pmc", "key": "PMC7453687"}], "notes": [], "created": "2020-12-07T07:50:31.006Z", "modified": "2021-02-26T08:45:47.937Z"}, {"entity": "publication", "iuid": "69088da76ece4cee8ec3e363bdd5b05b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69088da76ece4cee8ec3e363bdd5b05b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69088da76ece4cee8ec3e363bdd5b05b"}}, "title": "Stressors, coping and symptoms of adjustment disorder in the course of the COVID-19 pandemic - study protocol of the European Society for Traumatic Stress Studies (ESTSS) pan-European study.", "authors": [{"family": "Lotzin", "given": "Annett", "initials": "A"}, {"family": "Acquarini", "given": "Elena", "initials": "E"}, {"family": "Ajdukovic", "given": "Dean", "initials": "D"}, {"family": "Ardino", "given": "Vittoria", "initials": "V"}, {"family": "B\u00f6ttche", "given": "Maria", "initials": "M"}, {"family": "Bondjers", "given": "Kristina", "initials": "K"}, {"family": "Bragesj\u00f6", "given": "Maria", "initials": "M"}, {"family": "Dragan", "given": "Ma\u0142gorzata", "initials": "M"}, {"family": "Grajewski", "given": "Piotr", "initials": "P"}, {"family": "Figueiredo-Braga", "given": "Margarida", "initials": "M"}, {"family": "Gelezelyte", "given": "Odeta", "initials": "O"}, {"family": "Javakhishvili", "given": "Jana Darejan", "initials": "JD"}, {"family": "Kazlauskas", "given": "Evaldas", "initials": "E"}, {"family": "Knefel", "given": "Matthias", "initials": "M"}, {"family": "Lueger-Schuster", "given": "Brigitte", "initials": "B"}, {"family": "Makhashvili", "given": "Nino", "initials": "N"}, {"family": "Mooren", "given": "Trudy", "initials": "T"}, {"family": "Sales", "given": "Luisa", "initials": "L"}, {"family": "Stevanovic", "given": "Aleksandra", "initials": "A"}, {"family": "Sch\u00e4fer", "given": "Ingo", "initials": "I"}], "type": "journal article", "published": "2020-08-27", "journal": {"title": "Eur J Psychotraumatol", "issn": "2000-8066", "issn-l": null, "volume": "11", "issue": "1", "pages": "1780832"}, "abstract": "During the current COVID-19 pandemic, the people in Europe are exposed to self-isolation, quarantine, job loss, risk of contracting COVID-19, or grief of loved ones. Such a complex array of stressors may lead to symptoms of adjustment disorder or posttraumatic stress disorder. This research protocol describes a study launched by the European Society of Traumatic Stress Studies (ESTSS) to investigate the impact of the COVID-19 pandemic on symptoms of adjustment disorder across European countries.\r\n\r\nThe longitudinal online cohort study aims (1) to explore psychosocial reactions to the COVID-19 pandemic across ten European countries; (2) to examine the relationships between risk and resilience factors, stressors and symptoms of adjustment disorder during the pandemic; and (3) to investigate whether these relationships are moderated by coping behaviours.\r\n\r\nIn ten countries (Austria, Croatia, Georgia, Germany, Italy, Lithuania, Netherlands, Poland, Portugal, and Sweden), between 1,000 and 2,000 participants will be recruited, depending on the size of the country. Participants will be assessed at two timepoints with a six-month interval. Following a conceptual framework based on the WHO's social framework of health, an assessment of risk and resilience factors, COVID-19 related stressors and pandemic-specific coping behaviours will be measured to estimate their contribution to symptoms of adjustment disorder. The Adjustment Disorder New Module 8 (ADNM-8) will be used to assess symptoms of adjustment disorder. As a secondary measure, symptoms of posttraumatic stress disorder will be measure using the Primary Care PTSD Screen for DSM-5 (PC-PTSD-5).\r\n\r\nThe relative contribution of risk factors, resilience factors, and stressors on symptoms of adjustment disorder or symptoms of posttraumatic stress disorder will be estimated using multilevel analysis. To determine the moderating effects of different types of coping behaviours on these relationships, a multilevel mediation analysis will be carried out.", "doi": "10.1080/20008198.2020.1780832", "pmid": "33029321", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "1780832"}, {"db": "pmc", "key": "PMC7473046"}], "notes": [], "created": "2020-12-01T17:33:46.838Z", "modified": "2022-11-10T06:53:25.923Z"}, {"entity": "publication", "iuid": "d8fc9caf2b854bb09e32120e40f11dbb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d8fc9caf2b854bb09e32120e40f11dbb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d8fc9caf2b854bb09e32120e40f11dbb"}}, "title": "Quality Assessment of the Chinese Clinical Trial Protocols Regarding Treatments for Coronavirus Disease 2019.", "authors": [{"family": "Zhang", "given": "Jiaxing", "initials": "J"}, {"family": "Lu", "given": "Yiling", "initials": "Y"}, {"family": "Kwong", "given": "Joey Sum-Wing", "initials": "JS"}, {"family": "Li", "given": "Xiaosi", "initials": "X"}, {"family": "Zheng", "given": "Wenyi", "initials": "W"}, {"family": "He", "given": "Rui", "initials": "R"}], "type": "systematic review", "published": "2020-08-27", "journal": {"title": "Front Pharmacol", "issn": "1663-9812", "volume": "11", "issue": null, "pages": "1330", "issn-l": "1663-9812"}, "abstract": "With the global spread of coronavirus disease 2019 (COVID-19), an increasing number of clinical trials are being designed and executed to evaluate the efficacy and safety of various therapies for COVID-19. We conducted this survey to assess the methodological quality of registry protocols on potential treatments for COVID-19.\n\nClinical trial protocols were identified on the ClinicalTrials.gov and the Chinese Clinical Trial Registry. Protocols were screened by two investigators independently against pre-defined eligibility criteria. Quality of the included protocols was assessed according to the modified 14-item SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2013 Statement.\n\nWe included 82 randomized controlled trial (RCT) protocols investigating treatment modalities for COVID-19. These ongoing trials are being conducted in 16 provinces, autonomous regions, and municipalities of China, and study interventions were either Western medicines (n = 56) or traditional Chinese medicine (n = 26). Findings of our quality assessment indicated that the existing trial protocols could be further improved on several aspects, including selection and definition of outcome measures, descriptions of study interventions and comparators, study subject recruitment time, definition of study inclusion and exclusion criteria, and allocation concealment methods. Descriptions of random sequence generation methodologies were accurate for the majority of included trial protocols (n = 64; 78.05%); however, reporting of allocation concealment remained unclear in 63 (76.83%) protocols. Therefore, the overall risk of selection bias across these RCTs was judged to be unclear. A total of 52 (63.41%) included RCT protocols were open-label trials and are thus associated with a high risk of performance bias and detection bias.\n\nQuality of currently available RCT protocols on the treatments for COVID-19 could be further improved. For transparency and effective knowledge translation in real-world clinically settings, it is important for trial investigators to standardize baseline treatments for patients with COVID-19 and assess clinically important core outcome measures. Despite eager anticipation from the public on the results of effectiveness trials in COVID-19, robust design, execution, and reporting of these trials should be regarded as high priority.", "doi": "10.3389/fphar.2020.01330", "pmid": "32973535", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7481475"}], "notes": [], "created": "2020-11-26T12:35:59.498Z", "modified": "2020-11-27T12:42:08.264Z"}, {"entity": "publication", "iuid": "5dede475e5044e6fbfba60106ec06167", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5dede475e5044e6fbfba60106ec06167.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5dede475e5044e6fbfba60106ec06167"}}, "title": "Four SARS-CoV-2 Genome Sequences from Late April in Stockholm, Sweden, Reveal a Rare Mutation in the Spike Protein", "authors": [{"family": "Soratto", "given": "Tatiany Aparecida Teixeira", "initials": "TAT"}, {"family": "Darban", "given": "Hamid", "initials": "H"}, {"family": "Bjerkner", "given": "Annelie", "initials": "A"}, {"family": "Coorens", "given": "Maarten", "initials": "M"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Allander", "given": "Tobias", "initials": "T"}, {"family": "Andersson", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal-article", "published": "2020-08-27", "journal": {"title": "Microbiol Resour Announc", "issn": "2576-098X", "volume": "9", "issue": "35", "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1128/mra.00934-20", "pmid": null, "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null, "Category: Health": null}, "xrefs": [{"db": "ENA", "key": "https://www.ebi.ac.uk/ena/browser/view/PRJEB39632", "description": "ENA PRJEB39632: SARS-CoV-2 genomes from late April in Stockholm, Sweden (reads and consensus sequences)"}], "notes": [], "created": "2021-01-20T12:57:49.990Z", "modified": "2021-11-18T08:48:14.869Z"}, {"entity": "publication", "iuid": "1b2f511e17b149f28b7964815215754a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1b2f511e17b149f28b7964815215754a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1b2f511e17b149f28b7964815215754a"}}, "title": "The Impact and Consequences of SARS-CoV-2 Pandemic on a Single University Dermatology Outpatient Clinic in Germany.", "authors": [{"family": "Wang", "given": "Rosi", "initials": "R"}, {"family": "Helf", "given": "Charlotte", "initials": "C"}, {"family": "Tizek", "given": "Linda", "initials": "L"}, {"family": "Neuhauser", "given": "Ruth", "initials": "R"}, {"family": "Eyerich", "given": "Kilian", "initials": "K"}, {"family": "Zink", "given": "Alexander", "initials": "A"}, {"family": "Eberlein", "given": "Bernadette", "initials": "B"}, {"family": "Biedermann", "given": "Tilo", "initials": "T"}, {"family": "Brockow", "given": "Knut", "initials": "K"}, {"family": "Boehner", "given": "Alexander", "initials": "A"}], "type": "journal article", "published": "2020-08-26", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "17", "pages": null}, "abstract": "The pandemic outbreak of coronavirus disease 2019 (COVID-19) affects health care systems globally and leads to other challenges besides infection and its direct medical consequences. The aim of this study was to investigate the impact of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic on the university dermatology outpatient clinic (UDOC) of the Technical University of Munich, Germany. We analyzed datasets from 2015 until 2020 extracted from the hospital information system database and our documented outpatient files regarding patient numbers, gender, age, and diagnoses. In 2020, case numbers of outpatient care declined significantly ( p = 0.021) compared to previous years and was related to the timing of political announcements answering SARS-CoV-2 pandemic. Additionally, during calendar week 10 to 15-the peak time of the spread of COVID-19 in Germany-the proportion of patients missing their consultation was significantly higher in 2020 than in 2019 (22.4% vs. 12.4%; p < 0.001). Gender-associated differences regarding absences were not detected, but patients aged 85 years or older were significantly more likely to miss their consultation compared to all other age groups (p = 0.002). Regarding different disease clusters, patients with chronic inflammatory skin diseases and infectious and malignant diseases were more likely to miss their consultation (p = 0.006). Noticeably, less patients with malignant diseases, and particularly malignant melanoma, were registered during this pandemic. Our data support the hypothesis that medically constructive prioritization might not be implemented properly by patients themselves. Identifying missed patients and catching up on their medical care apart from COVID-19 will pose an enormous challenge for health care systems globally.", "doi": "10.3390/ijerph17176182", "pmid": "32858870", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "ijerph17176182"}, {"db": "pmc", "key": "PMC7504311"}], "notes": [], "created": "2020-12-07T10:21:15.928Z", "modified": "2022-11-10T06:54:44.823Z"}, {"entity": "publication", "iuid": "412ce737cca4490db9b405d33efbdd05", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/412ce737cca4490db9b405d33efbdd05.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/412ce737cca4490db9b405d33efbdd05"}}, "title": "Psychological impact of COVID-19 in the Swedish population: Depression, anxiety, and insomnia and their associations to risk and vulnerability factors.", "authors": [{"family": "McCracken", "given": "Lance M", "initials": "LM"}, {"family": "Badinlou", "given": "Farzaneh", "initials": "F"}, {"family": "Buhrman", "given": "Monica", "initials": "M"}, {"family": "Brocki", "given": "Karin C", "initials": "KC"}], "type": "journal article", "published": "2020-08-26", "journal": {"title": "Eur Psychiatry", "issn": "1778-3585", "issn-l": "0924-9338", "volume": "63", "issue": "1", "pages": "e81"}, "abstract": "The 2019 coronavirus disease (COVID-19) pandemic, with its associated restrictions on daily life, is like a perfect storm for poor mental health and wellbeing. The purpose of this study was therefore to examine the impacts of COVID-19 on mental health and wellbeing during the ongoing pandemic in Sweden.\r\n\r\nStandardized measures of depression, anxiety, and insomnia as well as measures of risk and vulnerability factors known to be associated with poor mental health outcomes were administered through a national, online, cross-sectional survey (n = 1,212; mean age 36.1 years; 73% women).\r\n\r\nOur findings show significant levels of depression, anxiety, and insomnia in Sweden, at rates of 30%, 24.2%, and 38%, respectively. The strongest predictors of these outcomes included poor self-rated overall health and a history of mental health problems. The presence of COVID-19 symptoms and specific health and financial worries related to the pandemic also appeared important.\r\n\r\nThe impacts of COVID-19 on mental health in Sweden are comparable to impacts shown in previous studies in Italy and China. Importantly, the pandemic seems to impose most on the mental health of those already burdened with the impacts of mental health problems. These results provide a basis for providing more support for vulnerable groups, and for developing psychological interventions suited to the ongoing pandemic and for similar events in the future.", "doi": "10.1192/j.eurpsy.2020.81", "pmid": "32843115", "labels": {"Type: Journal article": null, "Research Area: Host cell systems biology and targets": null, "Funder: VR": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0924933820000814"}, {"db": "pmc", "key": "PMC7503043"}], "notes": [], "created": "2020-11-22T09:57:25.705Z", "modified": "2022-11-10T06:55:13.268Z"}, {"entity": "publication", "iuid": "15f244f3562b4f0fb95392207e8d9726", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/15f244f3562b4f0fb95392207e8d9726.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/15f244f3562b4f0fb95392207e8d9726"}}, "title": "Thinking strategically for COVID-19: suppress and lift, to flatten or to crush?", "authors": [{"family": "Khalife", "given": "Jade", "initials": "J"}], "type": "journal article", "published": "2020-08-25", "journal": {"title": "East Mediterr Health J", "issn": "1687-1634", "volume": "26", "issue": "8", "pages": "877-878", "issn-l": null}, "abstract": null, "doi": "10.26719/emhj.20.091", "pmid": "32896879", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-06T07:17:29.471Z", "modified": "2020-12-06T07:17:29.492Z"}, {"entity": "publication", "iuid": "47b726dd88e94d50acb444651310dee1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47b726dd88e94d50acb444651310dee1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47b726dd88e94d50acb444651310dee1"}}, "title": "Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19.", "authors": [{"family": "Rodriguez", "given": "Lucie", "initials": "L"}, {"family": "Pekkarinen", "given": "Pirkka T", "initials": "PT"}, {"family": "Lakshmikanth", "given": "Tadepally", "initials": "T"}, {"family": "Tan", "given": "Ziyang", "initials": "Z"}, {"family": "Consiglio", "given": "Camila Rosat", "initials": "CR"}, {"family": "Pou", "given": "Christian", "initials": "C"}, {"family": "Chen", "given": "Yang", "initials": "Y"}, {"family": "Mugabo", "given": "Constantin Habimana", "initials": "CH"}, {"family": "Nguyen", "given": "Ngoc Anh", "initials": "NA"}, {"family": "Nowlan", "given": "Kirsten", "initials": "K"}, {"family": "Strandin", "given": "Tomas", "initials": "T"}, {"family": "Levanov", "given": "Lev", "initials": "L"}, {"family": "Mikes", "given": "Jaromir", "initials": "J"}, {"family": "Wang", "given": "Jun", "initials": "J"}, {"family": "Kantele", "given": "Anu", "initials": "A"}, {"family": "Hepojoki", "given": "Jussi", "initials": "J"}, {"family": "Vapalahti", "given": "Olli", "initials": "O"}, {"family": "Heinonen", "given": "Santtu", "initials": "S"}, {"family": "Kek\u00e4l\u00e4inen", "given": "Eliisa", "initials": "E"}, {"family": "Brodin", "given": "Petter", "initials": "P"}], "type": "journal article", "published": "2020-08-25", "journal": {"title": "Cell Rep Med", "issn": "2666-3791", "issn-l": "2666-3791", "volume": "1", "issue": "5", "pages": "100078"}, "abstract": "Severe disease of SARS-CoV-2 is characterized by vigorous inflammatory responses in the lung, often with a sudden onset after 5-7 days of stable disease. Efforts to modulate this hyperinflammation and the associated acute respiratory distress syndrome rely on the unraveling of the immune cell interactions and cytokines that drive such responses. Given that every patient is captured at different stages of infection, longitudinal monitoring of the immune response is critical and systems-level analyses are required to capture cellular interactions. Here, we report on a systems-level blood immunomonitoring study of 37 adult patients diagnosed with COVID-19 and followed with up to 14 blood samples from acute to recovery phases of the disease. We describe an IFN\u03b3-eosinophil axis activated before lung hyperinflammation and changes in cell-cell co-regulation during different stages of the disease. We also map an immune trajectory during recovery that is shared among patients with severe COVID-19.", "doi": "10.1016/j.xcrm.2020.100078", "pmid": "32838342", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://ki.app.box.com/s/sby0jesyu23a65cbgv51vpbzqjdmipr1", "description": "Raw mass cytometry data and the Olink protein data"}, {"db": "URL", "key": "https://github.com/rodriluc/SARS-CoV2_study", "description": "Analysis code"}, {"db": "URL", "key": "https://www.cell.com/cms/10.1016/j.xcrm.2020.100078/attachment/53aca693-33e7-4b26-881f-ea11c7c15ad1/mmc1.pdf", "description": "IgG data"}], "notes": [], "created": "2020-10-28T09:10:41.202Z", "modified": "2021-02-26T08:45:48.110Z"}, {"entity": "publication", "iuid": "b07cf88cd3a84c39b27242bbb46c99b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b07cf88cd3a84c39b27242bbb46c99b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b07cf88cd3a84c39b27242bbb46c99b3"}}, "title": "Social distancing laws cause only small losses of economic activity during the COVID-19 pandemic in Scandinavia.", "authors": [{"family": "Sheridan", "given": "Adam", "initials": "A"}, {"family": "Andersen", "given": "Asger Lau", "initials": "AL"}, {"family": "Hansen", "given": "Emil Toft", "initials": "ET"}, {"family": "Johannesen", "given": "Niels", "initials": "N"}], "type": "journal article", "published": "2020-08-25", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "117", "issue": "34", "pages": "20468-20473", "issn-l": "0027-8424"}, "abstract": "This paper uses real-time transaction data from a large bank in Scandinavia to estimate the effect of social distancing laws on consumer spending in the coronavirus 2019 (COVID-19) pandemic. The analysis exploits a natural experiment to disentangle the effects of the virus and the laws aiming to contain it: Denmark and Sweden were similarly exposed to the pandemic but only Denmark imposed significant restrictions on social and economic activities. We estimate that aggregate spending dropped by around 25% (95% CI: 24 to 26%) in Sweden and, as a result of the shutdown, by 4 additional percentage points (95% CI: 3 to 5 percentage points [p.p.]) in Denmark. This suggests that most of the economic contraction is caused by the virus itself and occurs regardless of social distancing laws. The age gradient in the estimates suggests that social distancing reinforces the virus-induced drop in spending for low-health-risk individuals but attenuates it for high-risk individuals by lowering the overall prevalence of the virus in the society.", "doi": "10.1073/pnas.2010068117", "pmid": "32747573", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "2010068117"}, {"db": "pmc", "key": "PMC7456178"}], "notes": [], "created": "2020-12-07T16:00:21.918Z", "modified": "2020-12-07T16:00:21.930Z"}, {"entity": "publication", "iuid": "1e96656d2f8b4ace83a45b4423931a25", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1e96656d2f8b4ace83a45b4423931a25.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1e96656d2f8b4ace83a45b4423931a25"}}, "title": "Interventions to suppress the coronavirus pandemic will increase unemployment and lead to many premature deaths.", "authors": [{"family": "Ros\u00e9n", "given": "M\u00e5ns", "initials": "M"}, {"family": "Stenbeck", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2020-08-25", "journal": {"title": "Scand J Public Health", "issn": "1651-1905", "issn-l": "1403-4948", "volume": null, "issue": null, "pages": "1403494820947974"}, "abstract": "Interventions to suppress the coronavirus pandemic have led to economic recession and higher unemployment, which will increase mortality and decrease quality of life. The aim of this article is to estimate the consequences on mortality and life expectancy of increased unemployment rates due to the coronavirus pandemic in Sweden and other countries.\r\n\r\nBased on recent increases and expected future unemployment rates due to the coronavirus pandemic, results from a systematic review and data from vital statistics in Sweden, the number of premature deaths due to unemployment in Sweden have been estimated.\r\n\r\nBased on our assumptions, the calculations show that if the number of unemployed persons in Sweden increases by 100,000, one may expect some 1800 more premature deaths during the following 9 years. If the duration of the recession is limited to 4 years, excess deaths due to unemployment may be around 800. On average, the unemployed will lose 2 years of their remaining life expectancy. In many other countries unemployment rates have or are estimated to rise more than in Sweden, sometimes two- or threefold, suggesting hundreds of thousands of excess deaths due to unemployment.\r\n\r\nInterventions to suppress the coronavirus pandemic include the shut-down of economic activities and lead to increased all-cause mortality. These public health effects must be considered in the decision-making process and should be added to overall estimates of the effects of the pandemic on public health.", "doi": "10.1177/1403494820947974", "pmid": "32842900", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2020-11-26T14:07:08.227Z", "modified": "2022-11-10T06:58:24.372Z"}, {"entity": "publication", "iuid": "99c39777a8b44be79113d736aaa9af74", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/99c39777a8b44be79113d736aaa9af74.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/99c39777a8b44be79113d736aaa9af74"}}, "title": "Immune responses during COVID-19 infection.", "authors": [{"family": "Melenotte", "given": "Cl\u00e9a", "initials": "C"}, {"family": "Silvin", "given": "Aymeric", "initials": "A"}, {"family": "Goubet", "given": "Anne-Ga\u00eblle", "initials": "AG"}, {"family": "Lahmar", "given": "Imran", "initials": "I"}, {"family": "Dubuisson", "given": "Agathe", "initials": "A"}, {"family": "Zumla", "given": "Alimuddin", "initials": "A"}, {"family": "Raoult", "given": "Didier", "initials": "D"}, {"family": "Merad", "given": "Mansouria", "initials": "M"}, {"family": "Gachot", "given": "Bertrand", "initials": "B"}, {"family": "H\u00e9non", "given": "Cl\u00e9mence", "initials": "C"}, {"family": "Solary", "given": "Eric", "initials": "E"}, {"family": "Fontenay", "given": "Michaela", "initials": "M"}, {"family": "Andr\u00e9", "given": "Fabrice", "initials": "F"}, {"family": "Maeurer", "given": "Markus", "initials": "M"}, {"family": "Ippolito", "given": "Giuseppe", "initials": "G"}, {"family": "Piacentini", "given": "Mauro", "initials": "M"}, {"family": "Wang", "given": "Fu-Sheng", "initials": "FS"}, {"family": "Ginhoux", "given": "Florent", "initials": "F"}, {"family": "Marabelle", "given": "Aur\u00e9lien", "initials": "A"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}, {"family": "Derosa", "given": "Lisa", "initials": "L"}, {"family": "Zitvogel", "given": "Laurence", "initials": "L"}], "type": "journal article", "published": "2020-08-25", "journal": {"title": "Oncoimmunology", "issn": "2162-4011", "volume": "9", "issue": "1", "pages": "1807836", "issn-l": null}, "abstract": "Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV (SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV) in 2012 and 2015, and SARS-CoV-2 in 2020, have been causing severe and fatal human epidemics. The unpredictability of coronavirus disease-19 (COVID-19) poses a major burden on health care and economic systems across the world. This is caused by the paucity of in-depth knowledge of the risk factors for severe COVID-19, insufficient diagnostic tools for the detection of SARS-CoV-2, as well as the absence of specific and effective drug treatments. While protective humoral and cellular immune responses are usually mounted against these betacoronaviruses, immune responses to SARS-CoV2 sometimes derail towards inflammatory tissue damage, leading to rapid admissions to intensive care units. The lack of knowledge on mechanisms that tilt the balance between these two opposite outcomes poses major threats to many ongoing clinical trials dealing with immunostimulatory or immunoregulatory therapeutics. This review will discuss innate and cognate immune responses underlying protective or deleterious immune reactions against these pathogenic coronaviruses.", "doi": "10.1080/2162402X.2020.1807836", "pmid": "32939324", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "1807836"}, {"db": "pmc", "key": "PMC7480812"}], "notes": [], "created": "2020-11-26T12:15:02.048Z", "modified": "2020-11-27T12:42:13.354Z"}, {"entity": "publication", "iuid": "fc8a52681ad84a3cb81c18e72172ee8b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc8a52681ad84a3cb81c18e72172ee8b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc8a52681ad84a3cb81c18e72172ee8b"}}, "title": "Has Sweden's controversial covid-19 strategy been successful or not?", "authors": [{"family": "Murray", "given": "John", "initials": "J"}], "type": "letter", "published": "2020-08-25", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "370", "issue": null, "pages": "m3255", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m3255", "pmid": "32843334", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-07T10:26:12.353Z", "modified": "2023-01-13T13:35:57.788Z"}, {"entity": "publication", "iuid": "9bdc4f367ba845b2be31cf156b1c4ebd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9bdc4f367ba845b2be31cf156b1c4ebd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9bdc4f367ba845b2be31cf156b1c4ebd"}}, "title": "An Ethics Framework for Making Resource Allocation Decisions Within Clinical Care: Responding to COVID-19.", "authors": [{"family": "Dawson", "given": "Angus", "initials": "A"}, {"family": "Isaacs", "given": "David", "initials": "D"}, {"family": "Jansen", "given": "Melanie", "initials": "M"}, {"family": "Jordens", "given": "Christopher", "initials": "C"}, {"family": "Kerridge", "given": "Ian", "initials": "I"}, {"family": "Kihlbom", "given": "Ulrik", "initials": "U"}, {"family": "Kilham", "given": "Henry", "initials": "H"}, {"family": "Preisz", "given": "Anne", "initials": "A"}, {"family": "Sheahan", "given": "Linda", "initials": "L"}, {"family": "Skowronski", "given": "George", "initials": "G"}], "type": "journal article", "published": "2020-08-25", "journal": {"title": "J Bioeth Inq", "issn": "1176-7529", "volume": null, "issue": null, "issn-l": null}, "abstract": "On March, 24, 2020, 818 cases of COVID-19 had been reported in New South Wales, Australia, and new cases were increasing at an exponential rate. In anticipation of resource constraints arising in clinical settings as a result of the COVID-19 pandemic, a working party of ten ethicists (seven clinicians and three full-time academics) was convened at the University of Sydney to draft an ethics framework to support resource allocation decisions. The framework guides decision-makers using a question-and-answer format, in language that avoids philosophical and medical technicality. The working party met five times over the following week and then submitted a draft Framework for consideration by two groups of intensivists and one group of academic ethicists. It was also presented to a panel on a national current affairs programme. The Framework was then revised on the basis of feedback from these sources and made publicly available online on April 3, ten days after the initial meeting. The framework is published here in full to stimulate ongoing discussion about rapid development of user-friendly clinical ethics resources in ongoing and future pandemics.", "doi": "10.1007/s11673-020-10007-w", "pmid": "32840833", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11673-020-10007-w"}, {"db": "pmc", "key": "PMC7445717"}], "notes": [], "created": "2020-12-07T10:28:14.151Z", "modified": "2020-12-07T10:28:14.173Z"}, {"entity": "publication", "iuid": "d4e822d3f5534290bc611a668851656b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d4e822d3f5534290bc611a668851656b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d4e822d3f5534290bc611a668851656b"}}, "title": "The burden of alcohol on health care during COVID-19.", "authors": [{"family": "Stockwell", "given": "Tim", "initials": "T"}, {"family": "Andreasson", "given": "Sven", "initials": "S"}, {"family": "Cherpitel", "given": "Cheryl", "initials": "C"}, {"family": "Chikritzhs", "given": "Tanya", "initials": "T"}, {"family": "Dangardt", "given": "Frida", "initials": "F"}, {"family": "Holder", "given": "Harold", "initials": "H"}, {"family": "Naimi", "given": "Timothy", "initials": "T"}, {"family": "Sherk", "given": "Adam", "initials": "A"}], "type": "journal article", "published": "2020-08-24", "journal": {"title": "Drug Alcohol Rev", "issn": "1465-3362", "volume": null, "issue": null, "issn-l": "0959-5236"}, "abstract": "Alcohol's impact on global health is substantial and of a similar order of magnitude to that from COVID-19. Alcohol now also poses specific concerns, such as increased risk of severe lung infections, domestic violence, child abuse, depression and suicide. Its use is unlikely to aid physical distancing or other preventative behavioural measures. Globally, alcohol contributes to 20% of injury and 11.5% of non-injury emergency room presentations. We provide some broad comparisons between alcohol-attributable and COVID-19-related hospitalisations and deaths in North America using most recent data. For example, for Canada in 2017 it was recently estimated there were 105 065 alcohol-attributable hospitalisations which represent a substantially higher rate over time than the 10 521 COVID-19 hospitalisations reported during the first 5 months of the pandemic. Despite the current importance of protecting health-care services, most governments have deemed alcohol sales to be as essential as food, fuel and pharmaceuticals. In many countries, alcohol is now more readily available and affordable than ever before, a situation global alcohol producers benefit from and have helped engineer. We argue that to protect frontline health-care services and public health more generally, it is essential that modest, evidence-based restrictions on alcohol prices, availability and marketing are introduced. In particular, we recommend increases in excise taxation coupled with minimum unit pricing to both reduce impacts on health-care services and provide much-needed revenues for governments at this critical time.", "doi": "10.1111/dar.13143", "pmid": "32835427", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7461236"}], "notes": [], "created": "2020-12-07T11:40:25.537Z", "modified": "2020-12-07T11:40:25.549Z"}, {"entity": "publication", "iuid": "5fcff184601b48c481ad4ca44cacbec0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5fcff184601b48c481ad4ca44cacbec0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5fcff184601b48c481ad4ca44cacbec0"}}, "title": "Immediate and long-term impact of the COVID-19 pandemic on delivery of surgical services", "authors": [{"family": "S\u00f8reide", "given": "K", "initials": "K", "orcid": "0000-0001-7594-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9c5655fc6aa437d91ed5cc2b4791543.json"}}, {"family": "Hallet", "given": "J", "initials": "J", "orcid": "0000-0001-5108-1072", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f2eee26bb4744bec88785a9a46843a7b.json"}}, {"family": "Matthews", "given": "J B", "initials": "JB"}, {"family": "Schnitzbauer", "given": "A A", "initials": "AA"}, {"family": "Line", "given": "P D", "initials": "PD"}, {"family": "Lai", "given": "P B S", "initials": "PBS"}, {"family": "Otero", "given": "J", "initials": "J"}, {"family": "Callegaro", "given": "D", "initials": "D"}, {"family": "Warner", "given": "S G", "initials": "SG"}, {"family": "Baxter", "given": "N N", "initials": "NN"}, {"family": "Teh", "given": "C S C", "initials": "CSC"}, {"family": "Ng-Kamstra", "given": "J", "initials": "J"}, {"family": "Meara", "given": "J G", "initials": "JG"}, {"family": "Hagander", "given": "L", "initials": "L"}, {"family": "Lorenzon", "given": "L", "initials": "L", "orcid": "0000-0001-6736-0383", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e2261efd5049432fa79781dece035f81.json"}}], "type": "journal-article", "published": "2020-08-24", "journal": {"title": "Br J Surg", "issn": "1365-2168", "volume": "107", "issue": "10", "pages": "1250-1261", "issn-l": null}, "abstract": "The ongoing pandemic is having a collateral health effect on delivery of surgical care to millions of patients. Very little is known about pandemic management and effects on other services, including delivery of surgery.\n\nThis was a scoping review of all available literature pertaining to COVID-19 and surgery, using electronic databases, society websites, webinars and preprint repositories.\n\nSeveral perioperative guidelines have been issued within a short time. Many suggestions are contradictory and based on anecdotal data at best. As regions with the highest volume of operations per capita are being hit, an unprecedented number of operations are being cancelled or deferred. No major stakeholder seems to have considered how a pandemic deprives patients with a surgical condition of resources, with patients disproportionally affected owing to the nature of treatment (use of anaesthesia, operating rooms, protective equipment, physical invasion and need for perioperative care). No recommendations exist regarding how to reopen surgical delivery. The postpandemic evaluation and future planning should involve surgical services as an essential part to maintain appropriate surgical care for the population during an outbreak. Surgical delivery, owing to its cross-cutting nature and synergistic effects on health systems at large, needs to be built into the WHO agenda for national health planning.\n\nPatients are being deprived of surgical access, with uncertain loss of function and risk of adverse prognosis as a collateral effect of the pandemic. Surgical services need a contingency plan for maintaining surgical care in an ongoing or postpandemic phase.", "doi": "10.1002/bjs.11670", "pmid": "32350857", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7267363"}], "notes": [], "created": "2020-11-30T15:53:12.325Z", "modified": "2021-12-06T12:58:21.582Z"}, {"entity": "publication", "iuid": "e34e09f4923d4ca98614c3edec114005", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e34e09f4923d4ca98614c3edec114005.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e34e09f4923d4ca98614c3edec114005"}}, "title": "Sex and gender: modifiers of health, disease, and medicine.", "authors": [{"family": "Mauvais-Jarvis", "given": "Franck", "initials": "F"}, {"family": "Bairey Merz", "given": "Noel", "initials": "N"}, {"family": "Barnes", "given": "Peter J", "initials": "PJ"}, {"family": "Brinton", "given": "Roberta D", "initials": "RD"}, {"family": "Carrero", "given": "Juan-Jesus", "initials": "JJ"}, {"family": "DeMeo", "given": "Dawn L", "initials": "DL"}, {"family": "De Vries", "given": "Geert J", "initials": "GJ"}, {"family": "Epperson", "given": "C Neill", "initials": "CN"}, {"family": "Govindan", "given": "Ramaswamy", "initials": "R"}, {"family": "Klein", "given": "Sabra L", "initials": "SL"}, {"family": "Lonardo", "given": "Amedeo", "initials": "A"}, {"family": "Maki", "given": "Pauline M", "initials": "PM"}, {"family": "McCullough", "given": "Louise D", "initials": "LD"}, {"family": "Regitz-Zagrosek", "given": "Vera", "initials": "V"}, {"family": "Regensteiner", "given": "Judith G", "initials": "JG"}, {"family": "Rubin", "given": "Joshua B", "initials": "JB"}, {"family": "Sandberg", "given": "Kathryn", "initials": "K"}, {"family": "Suzuki", "given": "Ayako", "initials": "A"}], "type": "journal article", "published": "2020-08-22", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "396", "issue": "10250", "pages": "565-582", "issn-l": "0140-6736"}, "abstract": "Clinicians can encounter sex and gender disparities in diagnostic and therapeutic responses. These disparities are noted in epidemiology, pathophysiology, clinical manifestations, disease progression, and response to treatment. This Review discusses the fundamental influences of sex and gender as modifiers of the major causes of death and morbidity. We articulate how the genetic, epigenetic, and hormonal influences of biological sex influence physiology and disease, and how the social constructs of gender affect the behaviour of the community, clinicians, and patients in the health-care system and interact with pathobiology. We aim to guide clinicians and researchers to consider sex and gender in their approach to diagnosis, prevention, and treatment of diseases as a necessary and fundamental step towards precision medicine, which will benefit men's and women's health.", "doi": "10.1016/S0140-6736(20)31561-0", "pmid": "32828189", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31561-0"}, {"db": "pmc", "key": "PMC7440877"}], "notes": [], "created": "2020-11-26T12:16:07.413Z", "modified": "2020-11-30T08:40:58.044Z"}, {"entity": "publication", "iuid": "9ca7de1ca24b481ab6dcc12f46bb0089", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9ca7de1ca24b481ab6dcc12f46bb0089.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9ca7de1ca24b481ab6dcc12f46bb0089"}}, "title": "Rapid Review of SARS-CoV-1 and SARS-CoV-2 Viability, Susceptibility to Treatment, and the Disinfection and Reuse of PPE, Particularly Filtering Facepiece Respirators.", "authors": [{"family": "Derraik", "given": "Jos\u00e9 G B", "initials": "JGB"}, {"family": "Anderson", "given": "William A", "initials": "WA"}, {"family": "Connelly", "given": "Elizabeth A", "initials": "EA"}, {"family": "Anderson", "given": "Yvonne C", "initials": "YC"}], "type": "journal article", "published": "2020-08-22", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "17", "issue": "17", "issn-l": null}, "abstract": "In the COVID-19 pandemic caused by SARS-CoV-2, hospitals are often stretched beyond capacity. There are widespread reports of dwindling supplies of personal protective equipment (PPE), particularly N95-type filtering facepiece respirators (FFRs), which are paramount to protect frontline medical/nursing staff, and to minimize further spread of the virus. We carried out a rapid review to summarize the existing literature on the viability of SARS-CoV-2, the efficacy of key potential disinfection procedures against the virus (specifically ultraviolet light and heat), and the impact of these procedures on FFR performance, material integrity, and/or fit. In light of the recent discovery of SARS-CoV-2 and limited associated research, our review also focused on the closely related SARS-CoV-1. We propose a possible whole-of-PPE disinfection solution for potential reuse that could be rapidly instituted in many health care settings, without significant investments in equipment.", "doi": "10.3390/ijerph17176117", "pmid": "32842655", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijerph17176117"}, {"db": "pmc", "key": "PMC7504573"}], "notes": [], "created": "2020-11-30T08:36:38.755Z", "modified": "2020-11-30T08:36:38.769Z"}, {"entity": "publication", "iuid": "7fd7c180f0204f0993b027f3d0d7bc81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7fd7c180f0204f0993b027f3d0d7bc81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7fd7c180f0204f0993b027f3d0d7bc81"}}, "title": "Natural killer cell immunotypes related to COVID-19 disease severity.", "authors": [{"family": "Maucourant", "given": "Christopher", "initials": "C", "orcid": "0000-0003-1033-2992", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb599f0df0bc42b88ddac10943ea3f6a.json"}}, {"family": "Filipovic", "given": "Iva", "initials": "I", "orcid": "0000-0002-8166-5500", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c79974df90ae4fbf8be348b9b47d0317.json"}}, {"family": "Ponzetta", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3224-802X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c8d6bca49dc24e558ca8f0b3637d7702.json"}}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Cornillet", "given": "Martin", "initials": "M", "orcid": "0000-0001-7981-0927", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20d0c2fd2be843668806a91d2d83104b.json"}}, {"family": "Hertwig", "given": "Laura", "initials": "L", "orcid": "0000-0002-1170-0948", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dbc76f6fbe8b4fcebfa928374618b304.json"}}, {"family": "Strunz", "given": "Benedikt", "initials": "B"}, {"family": "Lentini", "given": "Antonio", "initials": "A", "orcid": "0000-0003-1239-5495", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8c1f3989ef84f6d9803fb30b3014dc4.json"}}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Brownlie", "given": "Demi", "initials": "D", "orcid": "0000-0001-5932-6425", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/099513dbc2004b41a5017db9fee6b0b3.json"}}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Ask", "given": "Eivind Heggernes", "initials": "EH", "orcid": "0000-0001-8655-1433", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ad160fa96dd94738a713f5c6934e61fa.json"}}, {"family": "Hull", "given": "Ryan M", "initials": "RM", "orcid": "0000-0001-7153-4198", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/957f3dfe66c6442d897faa0eb44a0975.json"}}, {"family": "Haroun-Izquierdo", "given": "Alvaro", "initials": "A", "orcid": "0000-0003-4557-3606", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/eb8c47d324cb44c0baf2c78e93d849d2.json"}}, {"family": "Schaffer", "given": "Marie", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e9e5fcd2484a4df08d46eb56a71ca4b2.json"}}, {"family": "Folkesson", "given": "Elin", "initials": "E", "orcid": "0000-0002-6585-6235", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a96b0fba760f4aee8e45d11b79ddf6e0.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aae225e840304f9c8623d3ae4051e6af.json"}}, {"family": "Sandberg", "given": "Johan K", "initials": "JK", "orcid": "0000-0002-6275-0750", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/61225c074353413bb0b19c43b555732a.json"}}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Rooyackers", "given": "Olav", "initials": "O", "orcid": "0000-0002-3391-5448", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76700613a0f4410ab6c7d95658297e3f.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Malmberg", "given": "Karl-Johan", "initials": "KJ"}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Marquardt", "given": "Nicole", "initials": "N", "orcid": "0000-0003-3186-4752", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6ac381a2857740708edf9145a7c5531c.json"}}, {"family": "Hammer", "given": "Quirin", "initials": "Q", "orcid": "0000-0003-2968-6061", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0a71cf4c6d4d419daacba48ebd924238.json"}}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-8801-3169", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37509c3832244b019b91a1fe2cbe183e.json"}}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4691d38f3268433696d7c65ea235a12b.json"}}, {"family": "Karolinska COVID-19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-21", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "issn-l": "2470-9468", "volume": "5", "issue": "50", "pages": null}, "abstract": "Understanding innate immune responses in COVID-19 is important to decipher mechanisms of host responses and interpret disease pathogenesis. Natural killer (NK) cells are innate effector lymphocytes that respond to acute viral infections but might also contribute to immunopathology. Using 28-color flow cytometry, we here reveal strong NK cell activation across distinct subsets in peripheral blood of COVID-19 patients. This pattern was mirrored in scRNA-seq signatures of NK cells in bronchoalveolar lavage from COVID-19 patients. Unsupervised high-dimensional analysis of peripheral blood NK cells furthermore identified distinct NK cell immunotypes that were linked to disease severity. Hallmarks of these immunotypes were high expression of perforin, NKG2C, and Ksp37, reflecting increased presence of adaptive NK cells in circulation of patients with severe disease. Finally, arming of CD56bright NK cells was observed across COVID-19 disease states, driven by a defined protein-protein interaction network of inflammatory soluble factors. This study provides a detailed map of the NK cell activation landscape in COVID-19 disease.", "doi": "10.1126/sciimmunol.abd6832", "pmid": "32826343", "labels": {"Type: Journal article": null, "Funder: VR: Special COVID-19 funding": null, "Research Area: Host cell systems biology and targets": null, "Funder: KAW/SciLifeLab": null, "Funder: VR": null, "Research Area: Diagnostics for virus": null, "Research Area: Data-driven research \u2013 models and AI": null, "Category: Biochemistry": null, "Category: Genomics & transcriptomics": null, "Category: Imaging": null, "Category: Health": null, "Category: Other": null, "Category: Proteins": null}, "xrefs": [{"db": "pmc", "key": "PMC7665314"}, {"db": "pii", "key": "5/50/eabd6832"}], "notes": [], "created": "2020-10-28T09:12:39.024Z", "modified": "2023-06-19T15:01:40.035Z"}, {"entity": "publication", "iuid": "8adf9c36ef8841da9896b05a4ca7eae2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8adf9c36ef8841da9896b05a4ca7eae2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8adf9c36ef8841da9896b05a4ca7eae2"}}, "title": "Universal Basic Income as a Policy Response to COVID-19 and Precarious Employment: Potential Impacts on Rehabilitation and Return-to-Work.", "authors": [{"family": "St\u00e5hl", "given": "Christian", "initials": "C"}, {"family": "MacEachen", "given": "Ellen", "initials": "E"}], "type": "editorial", "published": "2020-08-20", "journal": {"title": "J Occup Rehabil", "issn": "1573-3688", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1007/s10926-020-09923-w", "pmid": "32816204", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10926-020-09923-w"}, {"db": "pmc", "key": "PMC7439237"}], "notes": [], "created": "2020-12-07T12:47:13.419Z", "modified": "2020-12-07T12:47:13.439Z"}, {"entity": "publication", "iuid": "6d3514760222420687c2e3be578a7782", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6d3514760222420687c2e3be578a7782.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6d3514760222420687c2e3be578a7782"}}, "title": "Sex and age differences in COVID-19 mortality in Europe&nbsp.", "authors": [{"family": "Ahrenfeldt", "given": "Linda Juel", "initials": "LJ"}, {"family": "Otavova", "given": "Martina", "initials": "M"}, {"family": "Christensen", "given": "Kaare", "initials": "K"}, {"family": "Lindahl-Jacobsen", "given": "Rune", "initials": "R"}], "type": "preprint", "published": "2020-08-19", "journal": {"title": "Res Sq", "issn": null, "volume": null, "issue": null, "issn-l": null}, "abstract": "To examine the magnitude of sex differences in survival from the Coronavirus Disease 2019 (COVID-19) in Europe across age and countries. We hypothesise that men have higher mortality than women at any given age, but that sex differences will decrease with age as only the strongest men survive to older ages. Aim: We used population data from Institut National D'\u00c9tudes D\u00e9mographiques on cumulative deaths due to COVID-19 from February to June 2020 in 10 European countries: Denmark, Norway, Sweden, The Netherlands, England & Wales, France, Germany, Italy, Spain and Portugal. For each country, we calculated cumulative mortality rates stratified by age and sex and corresponding relative risks for men vs. women. Methods: The relative risk of dying from COVID-19 was higher for men than for women in almost all age groups in all countries. The overall relative risk ranged from 1.11 (95% CI 1.01-1.23) in Portugal to 1.54 (95% CI 1.49-1.58) in France. In most countries, sex differences increased until ages 60-69 years, but decreased thereafter with the smallest sex difference at ages 80+. Results: Despite variability in data collection and time coverage among countries, we illustrate an overall similar pattern of sex differences in COVID-19 mortality in Europe.Conclusions:", "doi": "10.21203/rs.3.rs-61444/v1", "pmid": "32839767", "labels": {"Type: Preprint": null}, "xrefs": [{"db": "pmc", "key": "PMC7444295"}], "notes": [], "created": "2020-12-07T10:29:17.011Z", "modified": "2020-12-07T10:29:17.012Z"}, {"entity": "publication", "iuid": "473564f5c7634a5aa0fac6da9882b24d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/473564f5c7634a5aa0fac6da9882b24d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/473564f5c7634a5aa0fac6da9882b24d"}}, "title": "On-target versus off-target effects of drugs inhibiting the replication of SARS-CoV-2.", "authors": [{"family": "Sauvat", "given": "Allan", "initials": "A"}, {"family": "Ciccosanti", "given": "Fabiola", "initials": "F"}, {"family": "Colavita", "given": "Francesca", "initials": "F"}, {"family": "Di Rienzo", "given": "Martina", "initials": "M"}, {"family": "Castilletti", "given": "Concetta", "initials": "C"}, {"family": "Capobianchi", "given": "Maria Rosaria", "initials": "MR"}, {"family": "Kepp", "given": "Oliver", "initials": "O"}, {"family": "Zitvogel", "given": "Laurence", "initials": "L"}, {"family": "Fimia", "given": "Gian Maria", "initials": "GM"}, {"family": "Piacentini", "given": "Mauro", "initials": "M"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}], "type": "journal article", "published": "2020-08-19", "journal": {"title": "Cell Death Dis", "issn": "2041-4889", "issn-l": null, "volume": "11", "issue": "8", "pages": "656"}, "abstract": "The current epidemic of coronavirus disease-19 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) calls for the development of inhibitors of viral replication. Here, we performed a bioinformatic analysis of published and purported SARS-CoV-2 antivirals including imatinib mesylate that we found to suppress SARS-CoV-2 replication on Vero E6 cells and that, according to the published literature on other coronaviruses is likely to act on-target, as a tyrosine kinase inhibitor. We identified a cluster of SARS-CoV-2 antivirals with characteristics of lysosomotropic agents, meaning that they are lipophilic weak bases capable of penetrating into cells. These agents include cepharentine, chloroquine, chlorpromazine, clemastine, cloperastine, emetine, hydroxychloroquine, haloperidol, ML240, PB28, ponatinib, siramesine, and zotatifin (eFT226) all of which are likely to inhibit SARS-CoV-2 replication by non-specific (off-target) effects, meaning that they probably do not act on their 'official' pharmacological targets, but rather interfere with viral replication through non-specific effects on acidophilic organelles including autophagosomes, endosomes, and lysosomes. Imatinib mesylate did not fall into this cluster. In conclusion, we propose a tentative classification of SARS-CoV-2 antivirals into specific (on-target) versus non-specific (off-target) agents based on their physicochemical characteristics.", "doi": "10.1038/s41419-020-02842-x", "pmid": "32814759", "labels": {"Type: Journal article": null, "Funder: H2020": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41419-020-02842-x"}, {"db": "pmc", "key": "PMC7434849"}], "notes": [], "created": "2020-12-07T12:48:01.042Z", "modified": "2021-02-26T08:45:25.857Z"}, {"entity": "publication", "iuid": "8800fa8905744a2ca57d7934df8aa12f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8800fa8905744a2ca57d7934df8aa12f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8800fa8905744a2ca57d7934df8aa12f"}}, "title": "Labile PT-INR in a Covid-19 Patient Under Long-term Vitamin K Antagonist Therapy: a Case Report.", "authors": [{"family": "Trevisan", "given": "Caterina", "initials": "C"}, {"family": "Miconi", "given": "Lorella", "initials": "L"}, {"family": "Barbierato", "given": "Emanuele", "initials": "E"}, {"family": "Marinaro", "given": "Giuseppe", "initials": "G"}, {"family": "Targhetta", "given": "Stefano", "initials": "S"}, {"family": "D'agata", "given": "Mario", "initials": "M"}, {"family": "Rinaldi", "given": "Daniela", "initials": "D"}], "type": "journal article", "published": "2020-08-19", "journal": {"title": "SN Compr Clin Med", "issn": "2523-8973", "volume": null, "issue": null, "pages": "1-3", "issn-l": null}, "abstract": "The COronaVIrus Disease-19 (COVID-19) has been associated with thromboembolic complications, but evidence on its impact on hemorrhagic risk are still scarce. We describe a case of COVID-19 with hemorrhagic complication in the post-acute phase of the disease. The patient was a 93-year-old woman admitted to a post-acute care unit for COVID-19 patients in northern Italy. The patient's medical history included moderate cognitive impairment, atrial fibrillation under oral anticoagulation (warfarin 2.5 mg and 3.75 mg on alternate days, showing stable PT-INR values since October 2018), and arterial hypertension. The patient was affected by COVID-19, treated with supportive therapy. In the post-acute phase of the disease, the patient presented with melena and showed a marked elevation of PT-INR of 25.1. She was treated with venous infusion of three-factor prothrombin complex concentrate and vitamin K until PT-INR reduction. After 5 days, blood analyses revealed normal hemoglobin, PT-INR 2.15, and a slight alteration of liver function. This case supports a strong impact of the infection on the coagulative pattern not only pro-thrombotically but also by increasing hemorrhagic risk. Special attention should therefore be paid to COVID-19 patients under anticoagulation with vitamin K antagonist and a shift to heparin treatment until illness resolution may be a safe option in these individuals.", "doi": "10.1007/s42399-020-00460-4", "pmid": "32839751", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "460"}, {"db": "pmc", "key": "PMC7437640"}], "notes": [], "created": "2020-12-07T10:30:37.675Z", "modified": "2021-02-26T08:45:48.432Z"}, {"entity": "publication", "iuid": "32aab714fa474fba9d9f2878a97e395d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/32aab714fa474fba9d9f2878a97e395d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/32aab714fa474fba9d9f2878a97e395d"}}, "title": "The COVID-19 Pandemic and Its Impact on Children in Domestic Violence Refuges.", "authors": [{"family": "\u00d8verlien", "given": "Carolina", "initials": "C"}], "type": "journal article", "published": "2020-08-18", "journal": {"title": "Child Abuse Rev", "issn": "1099-0852", "volume": null, "issue": null, "issn-l": null}, "abstract": "The COVID-19 pandemic has resulted in negative consequences for children exposed to violence and abuse.Domestic violence refuge staff were greatly concerned about children both living outside and inside refuges.Domestic violence refuges have played a pivotal role during the COVID-19 pandemic and should receive wider acknowledgement and greater support for their work.", "doi": "10.1002/car.2650", "pmid": "32904999", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "CAR2650"}, {"db": "pmc", "key": "PMC7461223"}], "notes": [], "created": "2020-12-03T16:14:23.593Z", "modified": "2020-12-03T16:14:23.619Z"}, {"entity": "publication", "iuid": "7da622d92e2046018ed3ea5aeb2c889a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7da622d92e2046018ed3ea5aeb2c889a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7da622d92e2046018ed3ea5aeb2c889a"}}, "title": "Nanoscale Structural Characterization of Individual Viral Particles Using Atomic Force Microscopy Infrared Spectroscopy (AFM-IR) and Tip-Enhanced Raman Spectroscopy (TERS).", "authors": [{"family": "Dou", "given": "Tianyi", "initials": "T"}, {"family": "Li", "given": "Zhandong", "initials": "Z"}, {"family": "Zhang", "given": "Junjie", "initials": "J"}, {"family": "Evilevitch", "given": "Alex", "initials": "A"}, {"family": "Kurouski", "given": "Dmitry", "initials": "D"}], "type": "journal article", "published": "2020-08-18", "journal": {"title": "Anal Chem", "issn": "1520-6882", "volume": "92", "issue": "16", "pages": "11297-11304", "issn-l": null}, "abstract": "Viruses are infections species that infect a large spectrum of living systems. Although displaying a wide variety of shapes and sizes, they are all composed of nucleic acid encapsulated into a protein capsid. After virions enter the host cell, they replicate to produce multiple copies of themselves. They then lyse the host, releasing virions to infect new cells. The high proliferation rate of viruses is the underlying cause of their fast transmission among living species. Although many viruses are harmless, some of them are responsible for severe diseases such as AIDS, viral hepatitis, and flu. Traditionally, electron microscopy is used to identify and characterize viruses. This approach is time- and labor-consuming, which is problematic upon pandemic proliferation of previously unknown viruses, such as H1N1 and COVID-19. Herein, we demonstrate a novel diagnosis approach for label-free identification and structural characterization of individual viruses that is based on a combination of nanoscale Raman and infrared spectroscopy. Using atomic force microscopy-infrared (AFM-IR) spectroscopy, we were able to probe structural organization of the virions of Herpes Simplex Type 1 viruses and bacteriophage MS2. We also showed that tip-enhanced Raman spectroscopy (TERS) could be used to reveal protein secondary structure and amino acid composition of the virus surface. Our results show that AFM-IR and TERS provide different but complementary information about the structure of complex biological specimens. This structural information can be used for fast and reliable identification of viruses. This nanoscale bimodal imaging approach can be also used to investigate the origin of viral polymorphism and study mechanisms of virion assembly.", "doi": "10.1021/acs.analchem.0c01971", "pmid": "32683857", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-07T16:31:16.731Z", "modified": "2021-02-26T08:46:13.317Z"}, {"entity": "publication", "iuid": "6cb1c940d5e1434493243bf243fe4e1b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6cb1c940d5e1434493243bf243fe4e1b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6cb1c940d5e1434493243bf243fe4e1b"}}, "title": "Hyperinflammation and Fibrosis in Severe COVID-19 Patients: Galectin-3, a Target Molecule to Consider.", "authors": [{"family": "Garcia-Revilla", "given": "Juan", "initials": "J"}, {"family": "Deierborg", "given": "Tomas", "initials": "T"}, {"family": "Venero", "given": "Jose Luis", "initials": "JL"}, {"family": "Boza-Serrano", "given": "Antonio", "initials": "A"}], "type": "journal article", "published": "2020-08-18", "journal": {"title": "Front Immunol", "issn": "1664-3224", "issn-l": "1664-3224", "volume": "11", "issue": null, "pages": "2069"}, "abstract": "COVID-19 disease have become so far the most important sanitary crisis in the XXI century. In light of the events, any clinical resource should be considered to alleviate this crisis. Severe COVID-19 cases present a so-called cytokine storm as the most life-threatening symptom accompanied by lung fibrosis. Galectin-3 has been widely described as regulator of both processes. Hereby, we present compelling evidences on the potential role of galectin-3 in COVID-19 in the regulation of the inflammatory response, fibrosis and infection progression. Moreover, we provide a strong rationale of the utility of measuring plasma galectin-3 as a prognosis biomarker for COVID-19 patients and propose that inhibition of galectin-3 represents a feasible and promising new therapeutical approach.", "doi": "10.3389/fimmu.2020.02069", "pmid": "32973815", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7461806"}], "notes": [], "created": "2020-12-03T14:47:58.464Z", "modified": "2021-02-26T08:45:48.289Z"}, {"entity": "publication", "iuid": "02e13799c10c47cfbba71fec75ea0714", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/02e13799c10c47cfbba71fec75ea0714.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/02e13799c10c47cfbba71fec75ea0714"}}, "title": "A picture of medically assisted reproduction activities during the COVID-19 pandemic in Europe.", "authors": [{"family": "ESHRE COVID-19 Working Group ", "given": "", "initials": ""}, {"family": "Vermeulen", "given": "Nathalie", "initials": "N"}, {"family": "Ata", "given": "Baris", "initials": "B"}, {"family": "Gianaroli", "given": "Luca", "initials": "L"}, {"family": "Lundin", "given": "Kersti", "initials": "K"}, {"family": "Mocanu", "given": "Edgar", "initials": "E"}, {"family": "Rautakallio-Hokkanen", "given": "Satu", "initials": "S"}, {"family": "Tapanainen", "given": "Juha S", "initials": "JS"}, {"family": "Veiga", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2020-08-17", "journal": {"title": "Hum Reprod Open", "issn": "2399-3529", "volume": "2020", "issue": "3", "pages": "hoaa035", "issn-l": null}, "abstract": "How did coronavirus disease 2019 (COVID-19) impact on medically assisted reproduction (MAR) services in Europe during the COVID-19 pandemic (March to May 2020)?\n\nMAR services, and hence treatments for infertile couples, were stopped in most European countries for a mean of 7 weeks.\n\nWith the outbreak of COVID-19 in Europe, non-urgent medical care was reduced by local authorities to preserve health resources and maintain social distancing. Furthermore, ESHRE and other societies recommended to postpone ART pregnancies as of 14 March 2020.\n\nA structured questionnaire was distributed in April among the ESHRE Committee of National Representatives, followed by further information collection through email.\n\nThe information was collected through the questionnaire and afterwards summarised and aligned with data from the European Centre for Disease Control on the number of COVID-19 cases per country.\n\nBy aligning the data for each country with respective epidemiological data, we show a large variation in the time and the phase in the epidemic in the curve when MAR/ART treatments were suspended and restarted. Similarly, the duration of interruption varied. Fertility preservation treatments and patient supportive care for patients remained available during the pandemic.\n\nN/A.\n\nData collection was prone to misinterpretation of the questions and replies, and required further follow-up to check the accuracy. Some representatives reported that they, themselves, were not always aware of the situation throughout the country or reported difficulties with providing single generalised replies, for instance when there were regional differences within their country.\n\nThe current article provides a basis for further research of the different strategies developed in response to the COVID-19 crisis. Such conclusions will be invaluable for health authorities and healthcare professionals with respect to future similar situations.\n\nThere was no funding for the study, apart from technical support from ESHRE. The authors had no COI to disclose.", "doi": "10.1093/hropen/hoaa035", "pmid": "32821857", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "hoaa035"}, {"db": "pmc", "key": "PMC7430925"}], "notes": [], "created": "2020-12-07T12:20:35.064Z", "modified": "2020-12-07T12:20:35.086Z"}, {"entity": "publication", "iuid": "0c7d3bc6eeb44d1ca499293fdc7c0606", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c7d3bc6eeb44d1ca499293fdc7c0606.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c7d3bc6eeb44d1ca499293fdc7c0606"}}, "title": "Treatment of COVID-19 by Inhaled NO to Reduce Shunt?", "authors": [{"family": "Hedenstierna", "given": "G\u00f6ran", "initials": "G"}, {"family": "Chen", "given": "Luni", "initials": "L"}, {"family": "Hedenstierna", "given": "Magnus", "initials": "M"}, {"family": "Scaramuzzo", "given": "Gaetano", "initials": "G"}], "type": "letter", "published": "2020-08-15", "journal": {"title": "Am J Respir Crit Care Med", "issn": "1535-4970", "volume": "202", "issue": "4", "pages": "618", "issn-l": "1073-449X"}, "abstract": null, "doi": "10.1164/rccm.202004-0940LE", "pmid": "32579020", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7427390"}], "notes": [], "created": "2020-11-22T08:37:07.315Z", "modified": "2021-02-26T08:46:12.908Z"}, {"entity": "publication", "iuid": "86e22203b5eb4143a5423f1e195fd35d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86e22203b5eb4143a5423f1e195fd35d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86e22203b5eb4143a5423f1e195fd35d"}}, "title": "Untapped resources for medical research.", "authors": [{"family": "P\u00e9rez-Escobar", "given": "Oscar A", "initials": "OA"}, {"family": "Richardson", "given": "James E", "initials": "JE"}, {"family": "Howes", "given": "Melanie-Jayne R", "initials": "MR"}, {"family": "Lucas", "given": "Eve", "initials": "E"}, {"family": "\u00c1lvarez de R\u00f3man", "given": "Noelia", "initials": "N"}, {"family": "Collemare", "given": "J\u00e9r\u00f4me", "initials": "J"}, {"family": "Graham", "given": "Ian A", "initials": "IA"}, {"family": "Gratzfeld", "given": "Joachim", "initials": "J"}, {"family": "Kersey", "given": "Paul J", "initials": "PJ"}, {"family": "Leitch", "given": "Ilia J", "initials": "IJ"}, {"family": "Paton", "given": "Alan", "initials": "A"}, {"family": "Hollingsworth", "given": "Peter M", "initials": "PM"}, {"family": "Antonelli", "given": "Alexandre", "initials": "A"}], "type": "letter", "published": "2020-08-14", "journal": {"title": "Science", "issn": "1095-9203", "volume": "369", "issue": "6505", "pages": "781-782", "issn-l": "0036-8075"}, "abstract": null, "doi": "10.1126/science.abc8085", "pmid": "32792391", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "369/6505/781"}], "notes": [], "created": "2020-12-07T13:24:59.238Z", "modified": "2020-12-07T13:24:59.247Z"}, {"entity": "publication", "iuid": "d86a1fd91cdf4b48a66560ce4eea9a30", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d86a1fd91cdf4b48a66560ce4eea9a30.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d86a1fd91cdf4b48a66560ce4eea9a30"}}, "title": "A mathematical model reveals the influence of population heterogeneity on herd immunity to SARS-CoV-2.", "authors": [{"family": "Britton", "given": "Tom", "initials": "T", "orcid": "0000-0002-9228-7357", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3953e83bbffb428ab0a02f335979acb2.json"}}, {"family": "Ball", "given": "Frank", "initials": "F", "orcid": "0000-0002-5599-2903", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a08214bb29404f58b5286d6d1368b3e4.json"}}, {"family": "Trapman", "given": "Pieter", "initials": "P", "orcid": "0000-0003-0569-1659", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a2df9c9216143cd8219de8687414709.json"}}], "type": "journal article", "published": "2020-08-14", "journal": {"title": "Science", "issn": "1095-9203", "issn-l": "0036-8075", "volume": "369", "issue": "6505", "pages": "846-849"}, "abstract": "Despite various levels of preventive measures, in 2020, many countries have suffered severely from the coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Using a model, we show that population heterogeneity can affect disease-induced immunity considerably because the proportion of infected individuals in groups with the highest contact rates is greater than that in groups with low contact rates. We estimate that if R 0 = 2.5 in an age-structured community with mixing rates fitted to social activity, then the disease-induced herd immunity level can be ~43%, which is substantially less than the classical herd immunity level of 60% obtained through homogeneous immunization of the population. Our estimates should be interpreted as an illustration of how population heterogeneity affects herd immunity rather than as an exact value or even a best estimate.", "doi": "10.1126/science.abc6810", "pmid": "32576668", "labels": {"Funder: VR: Special COVID-19 funding": null, "Type: Journal article": null, "Funder: VR": null, "Funder: NordForsk": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7331793"}, {"db": "pii", "key": "science.abc6810"}], "notes": [], "created": "2020-12-04T09:13:31.584Z", "modified": "2023-06-19T15:26:16.461Z"}, {"entity": "publication", "iuid": "c17d5d63db7a4237b23fb9c1bfdf17fc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c17d5d63db7a4237b23fb9c1bfdf17fc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c17d5d63db7a4237b23fb9c1bfdf17fc"}}, "title": "Mismatch between circulating cytokines and spontaneous cytokine production by leukocytes in hyperinflammatory COVID-19.", "authors": [{"family": "Kahn", "given": "Robin", "initials": "R"}, {"family": "Schmidt", "given": "Tobias", "initials": "T"}, {"family": "Golestani", "given": "Karan", "initials": "K"}, {"family": "Mossberg", "given": "Anki", "initials": "A"}, {"family": "Gullstrand", "given": "Birgitta", "initials": "B"}, {"family": "Bengtsson", "given": "Anders A", "initials": "AA"}, {"family": "Kahn", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2020-08-13", "journal": {"title": "J Leukoc Biol", "issn": "1938-3673", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "The disease COVID-19 has developed into a worldwide pandemic. Hyperinflammation and high levels of several cytokines, for example, IL-6, are observed in severe COVID-19 cases. However, little is known about the cellular origin of these cytokines. Here, we investigated whether circulating leukocytes from patients with COVID-19 had spontaneous cytokine production. Patients with hyperinflammatory COVID-19 (n = 6) and sepsis (n = 3) were included at Sk\u00e5ne University Hospital, Sweden. Healthy controls were also recruited (n = 5). Cytokines were measured in COVID-19 and sepsis patients using an Immulite immunoassay system. PBMCs were cultured with brefeldin A to allow cytokine accumulation. In parallel, LPS was used as an activator. Cells were analyzed for cytokines and surface markers by flow cytometry. High levels of IL-6 and measurable levels of IL-8 and TNF, but not IL-1\u03b2, were observed in COVID-19 patients. Monocytes from COVID-19 patients had spontaneous production of IL-1\u03b2 and IL-8 (P = 0.0043), but not of TNF and IL-6, compared to controls. No spontaneous cytokine production was seen in lymphocytes from either patients or controls. Activation with LPS resulted in massive cytokine production by monocytes from COVID-19 patients and healthy controls, but not from sepsis patients. Finally, monocytes from COVID-19 patients produced more IL-1\u03b2 than from healthy controls (P = 0.0087) when activated. In conclusion, monocytes contribute partly to the ongoing hyperinflammation by production of IL-1\u03b2 and IL-8. Additionally, they are responsive to further activation. This data supports the notion of IL-1\u03b2 blockade in treatment of COVID-19. However, the source of the high levels of IL-6 remains to be determined.", "doi": "10.1002/JLB.5COVBCR0720-310RR", "pmid": "32794348", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7436862"}], "notes": [], "created": "2020-12-07T13:23:36.003Z", "modified": "2021-02-26T08:45:48.663Z"}, {"entity": "publication", "iuid": "cc3dfab3c1e149f682adb6e8c95794e5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc3dfab3c1e149f682adb6e8c95794e5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc3dfab3c1e149f682adb6e8c95794e5"}}, "title": "Does Self-isolation Violate the Right to Liberty? An Analysis of the European Court of Human Rights' Practice in Light of the Ukrainian Experience.", "authors": [{"family": "Litins'ka", "given": "Yana", "initials": "Y"}, {"family": "Karpenko", "given": "Oleksandra", "initials": "O"}], "type": "journal article", "published": "2020-08-13", "journal": {"title": "Eur J Health Law", "issn": "1571-8093", "issn-l": null, "volume": "27", "issue": "4", "pages": "368-385"}, "abstract": "COVID-19 became a stress-test for many legal systems because it required that a balance be found between rapid action to prevent the spread of the disease, and continued respect for human rights. Many states in Europe, including Ukraine, chose to enforce an obligation to self-isolate. In this article we review what the obligation to self-isolate entails in the case of Ukraine. We also analyse whether such an obligation should be viewed as a deprivation or a mere restriction of liberty, and if it is permissible under the European Convention for the Protection of Human Rights and Fundamental Freedoms.", "doi": "10.1163/15718093-BJA10024", "pmid": "33652392", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [], "notes": [], "created": "2021-03-03T17:02:20.206Z", "modified": "2022-11-10T07:09:04.422Z"}, {"entity": "publication", "iuid": "57f235418d50452785b82c709625d36a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/57f235418d50452785b82c709625d36a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/57f235418d50452785b82c709625d36a"}}, "title": "Key questions for modelling COVID-19 exit strategies.", "authors": [{"family": "Thompson", "given": "Robin N", "initials": "RN", "orcid": "0000-0001-8545-5212", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/463364e1efea442ca7c3c0964b5b7c88.json"}}, {"family": "Hollingsworth", "given": "T D\u00e9irdre", "initials": "TD", "orcid": "0000-0001-5962-4238", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d01e91cbf744ad4aa5c10b36df42255.json"}}, {"family": "Isham", "given": "Valerie", "initials": "V"}, {"family": "Arribas-Bel", "given": "Daniel", "initials": "D"}, {"family": "Ashby", "given": "Ben", "initials": "B", "orcid": "0000-0001-5588-7081", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e962d6776bb64ff6bd6d7a776c7323dd.json"}}, {"family": "Britton", "given": "Tom", "initials": "T"}, {"family": "Challenor", "given": "Peter", "initials": "P", "orcid": "0000-0001-8661-2718", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3b5d358c6c484ede8d2d1b95c69b3281.json"}}, {"family": "Chappell", "given": "Lauren H K", "initials": "LHK"}, {"family": "Clapham", "given": "Hannah", "initials": "H"}, {"family": "Cunniffe", "given": "Nik J", "initials": "NJ", "orcid": "0000-0002-3533-8672", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f49041a1dab140f1ab8ed5c8b9c0d502.json"}}, {"family": "Dawid", "given": "A Philip", "initials": "AP", "orcid": "0000-0002-7410-6882", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc052cc3ab66498e9d301c0508504f51.json"}}, {"family": "Donnelly", "given": "Christl A", "initials": "CA"}, {"family": "Eggo", "given": "Rosalind M", "initials": "RM", "orcid": "0000-0002-0362-6717", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f186dc5f7947456bb8ff489e19247592.json"}}, {"family": "Funk", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-2842-3406", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5f03dcbc41884648a4eac5892852899a.json"}}, {"family": "Gilbert", "given": "Nigel", "initials": "N", "orcid": "0000-0002-5937-2410", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5b438f3904e94df3be0a7371d0c5fb0a.json"}}, {"family": "Glendinning", "given": "Paul", "initials": "P"}, {"family": "Gog", "given": "Julia R", "initials": "JR"}, {"family": "Hart", "given": "William S", "initials": "WS", "orcid": "0000-0002-2504-6860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/35cc023f28a04e0b855d98ae0f6e6e12.json"}}, {"family": "Heesterbeek", "given": "Hans", "initials": "H"}, {"family": "House", "given": "Thomas", "initials": "T", "orcid": "0000-0001-5835-8062", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/48eb00c619034823b5ffce15e341d79a.json"}}, {"family": "Keeling", "given": "Matt", "initials": "M", "orcid": "0000-0003-4639-4765", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f72880a3fc6a42828e1fefe724ea3d6d.json"}}, {"family": "Kiss", "given": "Istv\u00e1n Z", "initials": "IZ", "orcid": "0000-0003-1473-6644", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2489413352f4748aa22dca0e980868f.json"}}, {"family": "Kretzschmar", "given": "Mirjam E", "initials": "ME"}, {"family": "Lloyd", "given": "Alun L", "initials": "AL", "orcid": "0000-0002-6389-6321", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9b29752d31364120a4078e5222a33014.json"}}, {"family": "McBryde", "given": "Emma S", "initials": "ES"}, {"family": "McCaw", "given": "James M", "initials": "JM", "orcid": "0000-0002-2452-3098", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/05468ff8cc244c989ddbb22d60028a48.json"}}, {"family": "McKinley", "given": "Trevelyan J", "initials": "TJ"}, {"family": "Miller", "given": "Joel C", "initials": "JC"}, {"family": "Morris", "given": "Martina", "initials": "M"}, {"family": "O'Neill", "given": "Philip D", "initials": "PD"}, {"family": "Parag", "given": "Kris V", "initials": "KV"}, {"family": "Pearson", "given": "Carl A B", "initials": "CAB", "orcid": "0000-0003-0701-7860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/37a6ce9807dd405ba6480a80965ab6d2.json"}}, {"family": "Pellis", "given": "Lorenzo", "initials": "L"}, {"family": "Pulliam", "given": "Juliet R C", "initials": "JRC"}, {"family": "Ross", "given": "Joshua V", "initials": "JV", "orcid": "0000-0002-9918-8167", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/15a5af493f004550bd0d431de09d7c1b.json"}}, {"family": "Tomba", "given": "Gianpaolo Scalia", "initials": "GS"}, {"family": "Silverman", "given": "Bernard W", "initials": "BW", "orcid": "0000-0002-4059-2376", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ec963dc6df3d4fb68a842a7fde234aa2.json"}}, {"family": "Struchiner", "given": "Claudio J", "initials": "CJ"}, {"family": "Tildesley", "given": "Michael J", "initials": "MJ"}, {"family": "Trapman", "given": "Pieter", "initials": "P", "orcid": "0000-0003-0569-1659", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a2df9c9216143cd8219de8687414709.json"}}, {"family": "Webb", "given": "Cerian R", "initials": "CR"}, {"family": "Mollison", "given": "Denis", "initials": "D"}, {"family": "Restif", "given": "Olivier", "initials": "O", "orcid": "0000-0001-9158-853X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1b62d897d36b42ba8bd57590d68d2899.json"}}], "type": "journal article", "published": "2020-08-12", "journal": {"title": "Proc Biol Sci", "issn": "1471-2954", "issn-l": null, "volume": "287", "issue": "1932", "pages": "20201405"}, "abstract": "Combinations of intense non-pharmaceutical interventions (lockdowns) were introduced worldwide to reduce SARS-CoV-2 transmission. Many governments have begun to implement exit strategies that relax restrictions while attempting to control the risk of a surge in cases. Mathematical modelling has played a central role in guiding interventions, but the challenge of designing optimal exit strategies in the face of ongoing transmission is unprecedented. Here, we report discussions from the Isaac Newton Institute 'Models for an exit strategy' workshop (11-15 May 2020). A diverse community of modellers who are providing evidence to governments worldwide were asked to identify the main questions that, if answered, would allow for more accurate predictions of the effects of different exit strategies. Based on these questions, we propose a roadmap to facilitate the development of reliable models to guide exit strategies. This roadmap requires a global collaborative effort from the scientific community and policymakers, and has three parts: (i) improve estimation of key epidemiological parameters; (ii) understand sources of heterogeneity in populations; and (iii) focus on requirements for data collection, particularly in low-to-middle-income countries. This will provide important information for planning exit strategies that balance socio-economic benefits with public health.", "doi": "10.1098/rspb.2020.1405", "pmid": "32781946", "labels": {"Type: Review": null, "Funder: VR": null}, "xrefs": [{"db": "pmc", "key": "PMC7575516"}], "notes": [], "created": "2020-11-30T08:41:04.303Z", "modified": "2023-06-19T15:26:28.252Z"}, {"entity": "publication", "iuid": "7bf0541d70e84f2da1fffa80763585ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7bf0541d70e84f2da1fffa80763585ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7bf0541d70e84f2da1fffa80763585ff"}}, "title": "Does the Prosperity of a Country Play a Role in COVID-19 Outcomes?", "authors": [{"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}, {"family": "Carlstr\u00f6m", "given": "Eric", "initials": "E"}, {"family": "Hertelendy", "given": "Attila J", "initials": "AJ"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}, {"family": "Casady", "given": "Carter B", "initials": "CB"}, {"family": "Burkle", "given": "Frederick M", "initials": "FM"}], "type": "journal article", "published": "2020-08-12", "journal": {"title": "Disaster Med Public Health Prep", "issn": "1938-744X", "issn-l": "1935-7893", "volume": null, "issue": null, "pages": "1-10"}, "abstract": "This study aims to clarify the association between prosperity and the coronavirus disease (COVID-19) outcomes and its impact on the future management of pandemics.\r\n\r\nThis is an observational study using information from 2 online registries. The numbers of infected individuals and deaths and the prosperity rank of each country were obtained from worldometer.info and the Legatum Institute's Prosperity Index, respectively.\r\n\r\nThere is a combination of countries with high and low prosperity on the list of COVID-19-infected countries. The risk of the virus pandemic seems to be more extensive in countries with high prosperity. A Spearman's rho test confirmed a significant correlation between prosperity, the number of COVID-19 cases, and the number of deaths at the 99% level.\r\n\r\nNew emerging pandemics affect all nations. In order to increase the likelihood of successfully managing future events, it is important to consider preexisting health security, valid population-based management approaches, medical decision-making, communication, continuous assessment, triage, treatment, early and complete physical distancing strategies, and logistics. These elements cannot be taught on-site and on occasion. There is a need for innovative and regular educational activities for all stakeholders committed to safeguarding our future defense systems concerning diagnostic, protection, treatment, and rehabilitation in pandemics, as well as other emergencies.", "doi": "10.1017/dmp.2020.304", "pmid": "32782059", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S1935789320003043"}, {"db": "pmc", "key": "PMC7477401"}], "notes": [], "created": "2020-12-07T13:29:22.810Z", "modified": "2022-11-10T07:09:49.459Z"}, {"entity": "publication", "iuid": "f232eaf8e0594f659f7ff3d2ea8bf32a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f232eaf8e0594f659f7ff3d2ea8bf32a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f232eaf8e0594f659f7ff3d2ea8bf32a"}}, "title": "Pronounced difference in Covid-19 antibody prevalence indicates cluster transmission in Stockholm, Sweden.", "authors": [{"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Hanson", "given": "Stefan", "initials": "S"}, {"family": "Olsen", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2020-08-11", "journal": {"title": "Infect Ecol Epidemiol", "issn": "2000-8686", "issn-l": "2000-8686", "volume": "10", "issue": "1", "pages": "1806505"}, "abstract": "The prevalence of COVID-19 antibodies on June 17-18, 2020 was investigated in two residential areas of Stockholm, Sweden. Among the residents in Norra Djurg\u00e5rdsstaden, a newly built upper- and middle-class area of Stockholm, 4.1% of study participants had SARS-CoV-2-specific antibodies, while in Tensta, a highly segregated low-income area, 30% of the participants tested antibody positive.", "doi": "10.1080/20008686.2020.1806505", "pmid": "32944166", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "pii", "key": "1806505"}, {"db": "pmc", "key": "PMC7480443"}], "notes": [], "created": "2020-11-11T07:20:08.508Z", "modified": "2021-02-26T08:45:14.498Z"}, {"entity": "publication", "iuid": "420ece91e6c44fd8b90a235a80a7e4d3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/420ece91e6c44fd8b90a235a80a7e4d3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/420ece91e6c44fd8b90a235a80a7e4d3"}}, "title": "Obesity as a contributor to immunopathology in pregnant and non-pregnant adults with COVID-19.", "authors": [{"family": "McCartney", "given": "Stephen A", "initials": "SA"}, {"family": "Kachikis", "given": "Alisa", "initials": "A"}, {"family": "Huebner", "given": "Emily M", "initials": "EM"}, {"family": "Walker", "given": "Christie L", "initials": "CL"}, {"family": "Chandrasekaran", "given": "Suchi", "initials": "S"}, {"family": "Adams Waldorf", "given": "Kristina M", "initials": "KM"}], "type": "journal article", "published": "2020-08-11", "journal": {"title": "Am J Reprod Immunol", "issn": "1600-0897", "volume": null, "issue": null, "pages": "e13320", "issn-l": null}, "abstract": "The ongoing coronavirus disease 2019 (COVID-19) pandemic has led to a global public health emergency with the need to identify vulnerable populations who may benefit from increased screening and healthcare resources. Initial data suggest that overall, pregnancy is not a significant risk factor for severe coronavirus disease 2019 (COVID-19). However, case series have suggested that maternal obesity is one of the most important comorbidities associated with more severe disease. In obese individuals, suppressors of cytokine signaling are upregulated and type I and III interferon responses are delayed and blunted leading to ineffective viral clearance. Obesity is also associated with changes in systemic immunity involving a wide range of immune cells and mechanisms that lead to low-grade chronic inflammation, which can compromise antiviral immunity. Macrophage activation in adipose tissue can produce low levels of pro-inflammatory cytokines (TNF-\u03b1, IL-1\u03b2, IL-6). Further, adipocyte secretion of leptin is pro-inflammatory and high circulating levels of leptin have been associated with mortality in patients with acute respiratory distress syndrome. The synergistic effects of obesity-associated delays in immune control of COVID-19 with mechanical stress of increased adipose tissue may contribute to a greater risk of pulmonary compromise in obese pregnant women. In this review, we bring together data regarding obesity as a key co-morbidity for COVID-19 in pregnancy with known changes in the antiviral immune response associated with obesity. We also describe how the global burden of obesity among reproductive age women has serious public health implications for COVID-19.", "doi": "10.1111/aji.13320", "pmid": "32779790", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7435524"}], "notes": [], "created": "2020-11-30T08:41:05.562Z", "modified": "2020-11-30T08:41:05.587Z"}, {"entity": "publication", "iuid": "0e58ba01cbcf49a091eabdf7e0ffa9c1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0e58ba01cbcf49a091eabdf7e0ffa9c1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0e58ba01cbcf49a091eabdf7e0ffa9c1"}}, "title": "Laparoscopic Surgery and the debate on its safety during COVID-19 pandemic: A systematic review of recommendations.", "authors": [{"family": "El Boghdady", "given": "Michael", "initials": "M"}, {"family": "Ewalds-Kvist", "given": "Beatrice Marianne", "initials": "BM"}], "type": "journal article", "published": "2020-08-11", "journal": {"title": "Surgeon", "issn": "1479-666X", "volume": null, "issue": null, "issn-l": null}, "abstract": "The transmission of COVID-19 virus since the outbreak of viral pneumonia due to SARS-CoV-2 gave rise to protective operative measures. Aerosol generating procedures such as laparoscopic surgery are known to be associated with increased risks of viral transmission to the healthcare workers. The safety of laparoscopy during the pandemic was then debated. We aimed to systematically review the literature regarding the safe use of laparoscopy during COVID-19.\n\nWe performed a systematic search using PubMed and ScienceDirect databases from inception to 1st May, 2020. The following search terms were used: ''laparoscopic surgery and COVID-19''; ''minimally invasive surgery and COVID-19''. Search items were considered from the nature of the articles, date of publication, aims and findings in relation to use of laparoscopic surgery during COVID-19. The study protocol was registered with PROSPERO register for systematic reviews (CRD42020183432).\n\nAltogether, 174 relevant citations were identified and reviewed for this study, of which 22 articles were included. The analysis of the findings in relation to laparoscopic surgery during the pandemic were presented in tabular form. We completed the common recommendations for performing laparoscopy during the COVID-19 pandemic in forms of pre-, intra- and postoperative phases.\n\nThere is no scientific evidence to date for the transmission of COVID-19 by laparoscopic surgery. Laparoscopy can be used with precautions because of its benefits compared to open surgery. If safe, conservative management is the primary alternative during the pandemic. We concluded that recommended precautions should be respected while performing laparoscopy during the pandemic.", "doi": "10.1016/j.surge.2020.07.005", "pmid": "32855070", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1479-666X(20)30104-9"}, {"db": "pmc", "key": "PMC7418789"}], "notes": [], "created": "2020-11-30T08:36:34.178Z", "modified": "2020-11-30T08:36:34.199Z"}, {"entity": "publication", "iuid": "50dc122d0f144aa1b9ccd32a5da53091", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50dc122d0f144aa1b9ccd32a5da53091.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50dc122d0f144aa1b9ccd32a5da53091"}}, "title": "Comprehensive Overview on Multiple Strategies Fighting COVID-19.", "authors": [{"family": "Khalifa", "given": "Shaden A M", "initials": "SAM"}, {"family": "Mohamed", "given": "Briksam S", "initials": "BS"}, {"family": "Elashal", "given": "Mohamed H", "initials": "MH"}, {"family": "Du", "given": "Ming", "initials": "M"}, {"family": "Guo", "given": "Zhiming", "initials": "Z"}, {"family": "Zhao", "given": "Chao", "initials": "C"}, {"family": "Musharraf", "given": "Syed Ghulam", "initials": "SG"}, {"family": "Boskabady", "given": "Mohammad H", "initials": "MH"}, {"family": "El-Seedi", "given": "Haged H R", "initials": "HHR"}, {"family": "Efferth", "given": "Thomas", "initials": "T"}, {"family": "El-Seedi", "given": "Hesham R", "initials": "HR"}], "type": "journal article", "published": "2020-08-11", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "volume": "17", "issue": "16", "issn-l": null}, "abstract": "Lately, myriad of novel viruses have emerged causing epidemics such as SARS, MERS, and SARS-CoV-2, leading to high mortality rates worldwide. Thus, these viruses represented a challenging threat to mankind, especially considering the miniscule data available at our disposal regarding these novel viruses. The entire world established coordinative relations in research projects regarding drug and vaccine development on the external range, whereas on the internal range, all countries declared it an emergency case through imposing different restrictions related to their border control, large gatherings, school attendance, and most social activities. Pandemic combating plans prioritized all sectors including normal people, medical staff politicians, and scientists collectively shouldered the burden. Through planning and learning the previous lessons from SARS and MERS, healthcare systems could succeed in combating the viral spread and implications of these new pandemics. Different management strategies including social distance, social awareness and isolation represented successful ways to slow down the spread of the pandemic. Furthermore, pre-preparedness of some countries for emergencies is crucial to minimize the consequences of the crisis.", "doi": "10.3390/ijerph17165813", "pmid": "32796733", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijerph17165813"}, {"db": "pmc", "key": "PMC7460286"}], "notes": [], "created": "2020-11-30T08:41:00.511Z", "modified": "2020-11-30T08:41:00.525Z"}, {"entity": "publication", "iuid": "1e17e4cbd29741e2aa6ca44f3c385dab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1e17e4cbd29741e2aa6ca44f3c385dab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1e17e4cbd29741e2aa6ca44f3c385dab"}}, "title": "Children's Anxiety and Factors Related to the COVID-19 Pandemic: An Exploratory Study Using the Children's Anxiety Questionnaire and the Numerical Rating Scale.", "authors": [{"family": "Garcia de Avila", "given": "Marla Andr\u00e9ia", "initials": "MA"}, {"family": "Hamamoto Filho", "given": "Pedro Tadao", "initials": "PT"}, {"family": "Jacob", "given": "Francine Let\u00edcia da Silva", "initials": "FLdS"}, {"family": "Alcantara", "given": "L\u00e9ia Regina Souza", "initials": "LRS"}, {"family": "Berghammer", "given": "Malin", "initials": "M"}, {"family": "Jenholt Nolbris", "given": "Margaretha", "initials": "M"}, {"family": "Olaya-Contreras", "given": "Patricia", "initials": "P"}, {"family": "Nilsson", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2020-08-09", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "16", "pages": null}, "abstract": "The repercussions of the COVID-19 pandemic on children's lives deserve attention. This study aimed to assess the prevalence of anxiety among Brazilian children and its associated factors during social distancing during COVID-19. We used a cross-sectional design with an online survey from April to May 2020 in Brazil. We included children aged 6-12 years and their guardians. The Children's Anxiety Questionnaire (CAQ; scores 4-12) and the Numerical Rating Scale (NRS; scores 0-10) were used to measure anxiety. We enrolled 157 girls and 132 boys, with a mean age of 8.84 (\u00b12.05) years; 88.9% of respondents were mothers. Based on CAQ \u2265 9, the prevalence of anxiety was 19.4% (n = 56), and higher among children with parents with essential jobs and those who were social distancing without parents. In logistic regression, the following variables were associated with higher CAQ scores: social distancing without parents; more persons living together in home; and education level of guardians. Based on NRS > 7, the prevalence of anxiety was 21.8% (n = 63); however, no associations with NRS scores were found with the investigated variables. These findings suggest the necessity of implementing public health actions targeting these parents and their children at the population level.", "doi": "10.3390/ijerph17165757", "pmid": "32784898", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "ijerph17165757"}, {"db": "pmc", "key": "PMC7459447"}], "notes": [], "created": "2020-12-07T13:28:53.440Z", "modified": "2022-11-10T07:11:07.153Z"}, {"entity": "publication", "iuid": "a94013a0dc4a4d148aa66becf6e8a548", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a94013a0dc4a4d148aa66becf6e8a548.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a94013a0dc4a4d148aa66becf6e8a548"}}, "title": "Symptoms of burnout in intensive care unit specialists facing the COVID-19 outbreak.", "authors": [{"family": "Azoulay", "given": "Elie", "initials": "E"}, {"family": "De Waele", "given": "Jan", "initials": "J"}, {"family": "Ferrer", "given": "Ricard", "initials": "R"}, {"family": "Staudinger", "given": "Thomas", "initials": "T"}, {"family": "Borkowska", "given": "Marta", "initials": "M"}, {"family": "Povoa", "given": "Pedro", "initials": "P"}, {"family": "Iliopoulou", "given": "Katerina", "initials": "K"}, {"family": "Artigas", "given": "Antonio", "initials": "A"}, {"family": "Schaller", "given": "Stefan J", "initials": "SJ"}, {"family": "Hari", "given": "Manu Shankar", "initials": "MS"}, {"family": "Pellegrini", "given": "Mariangela", "initials": "M"}, {"family": "Darmon", "given": "Michael", "initials": "M"}, {"family": "Kesecioglu", "given": "Jozef", "initials": "J"}, {"family": "Cecconi", "given": "Maurizio", "initials": "M"}, {"family": "ESICM", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-08", "journal": {"title": "Ann Intensive Care", "issn": "2110-5820", "volume": "10", "issue": "1", "pages": "110", "issn-l": null}, "abstract": "The COVID-19 pandemic has resulted in an unprecedented healthcare crisis with a high prevalence of psychological distress in healthcare providers. We sought to document the prevalence of burnout syndrome amongst intensivists facing the COVID-19 outbreak.\n\nCross-sectional survey among intensivists part of the European Society of Intensive Care Medicine. Symptoms of severe burnout, anxiety and depression were collected. Factors independently associated with severe burnout were assessed using Cox model.\n\nResponse rate was 20% (1001 completed questionnaires were returned, 45 years [39-53], 34% women, from 85 countries, 12 regions, 50% university-affiliated hospitals). The prevalence of symptoms of anxiety and depression or severe burnout was 46.5%, 30.2%, and 51%, respectively, and varied significantly across regions. Rating of the relationship between intensivists and other ICU stakeholders differed significantly according to the presence of anxiety, depression, or burnout. Similar figures were reported for their rating of the ethical climate or the quality of the decision-making. Factors independently associated with anxiety were female gender (HR 1.85 [1.33-2.55]), working in a university-affiliated hospital (HR 0.58 [0.42-0.80]), living in a city of > 1 million inhabitants (HR 1.40 [1.01-1.94]), and clinician's rating of the ethical climate (HR 0.83 [0.77-0.90]). Independent determinants of depression included female gender (HR 1.63 [1.15-2.31]) and clinician's rating of the ethical climate (HR 0.84 [0.78-0.92]). Factors independently associated with symptoms of severe burnout included age (HR 0.98/year [0.97-0.99]) and clinician's rating of the ethical climate (HR 0.76 [0.69-0.82]).\n\nThe COVID-19 pandemic has had an overwhelming psychological impact on intensivists. Follow-up, and management are warranted to assess long-term psychological outcomes and alleviate the psychological burden of the pandemic on frontline personnel.", "doi": "10.1186/s13613-020-00722-3", "pmid": "32770449", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13613-020-00722-3"}, {"db": "pmc", "key": "PMC7414284"}], "notes": [], "created": "2020-12-07T13:34:57.801Z", "modified": "2020-12-07T13:35:52.082Z"}, {"entity": "publication", "iuid": "d45fc21e8154403c809bf4467cd00f70", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d45fc21e8154403c809bf4467cd00f70.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d45fc21e8154403c809bf4467cd00f70"}}, "title": "COVID-19-a very visible pandemic.", "authors": [{"family": "Ewing", "given": "Andrew", "initials": "A"}], "type": "letter", "published": "2020-08-08", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "396", "issue": "10248", "pages": "e18", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)31676-7", "pmid": "32771113", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31676-7"}], "notes": [], "created": "2020-12-07T13:34:10.903Z", "modified": "2020-12-07T13:34:10.913Z"}, {"entity": "publication", "iuid": "fb03bfdb9d4845aa81ab5fc091a90b93", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb03bfdb9d4845aa81ab5fc091a90b93.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb03bfdb9d4845aa81ab5fc091a90b93"}}, "title": "COVID-19-a very visible pandemic.", "authors": [{"family": "King", "given": "Carina", "initials": "C"}, {"family": "Einhorn", "given": "Lena", "initials": "L"}, {"family": "Brusselaers", "given": "Nele", "initials": "N"}, {"family": "Carlsson", "given": "Marcus", "initials": "M"}, {"family": "Einhorn", "given": "Stefan", "initials": "S"}, {"family": "Elgh", "given": "Fredrik", "initials": "F"}, {"family": "Fris\u00e9n", "given": "Jonas", "initials": "J"}, {"family": "Gustafsson", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Hanson", "given": "Stefan", "initials": "S"}, {"family": "Hanson", "given": "Claudia", "initials": "C"}, {"family": "Hedner", "given": "Thomas", "initials": "T"}, {"family": "Isaksson", "given": "Olle", "initials": "O"}, {"family": "Jansson", "given": "Anders", "initials": "A"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "L\u00f6tvall", "given": "Jan", "initials": "J"}, {"family": "Lundback", "given": "Bo", "initials": "B"}, {"family": "Olsen", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "S\u00f6derberg-Naucl\u00e9r", "given": "Cecilia", "initials": "C"}, {"family": "Wahlin", "given": "Anders", "initials": "A"}, {"family": "Steineck", "given": "Gunner", "initials": "G"}, {"family": "Vahlne", "given": "Anders", "initials": "A"}], "type": "letter", "published": "2020-08-08", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "396", "issue": "10248", "pages": "e15", "issn-l": "0140-6736"}, "abstract": "Review", "doi": "10.1016/S0140-6736(20)31672-X", "pmid": "32771110", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31672-X"}], "notes": [], "created": "2020-11-11T07:18:55.672Z", "modified": "2020-12-07T13:34:19.209Z"}, {"entity": "publication", "iuid": "046b2eb278b84654a47ee7b17c847c38", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/046b2eb278b84654a47ee7b17c847c38.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/046b2eb278b84654a47ee7b17c847c38"}}, "title": "COVID-19-a very visible pandemic.", "authors": [{"family": "Lindahl", "given": "Johanna F", "initials": "JF"}, {"family": "Olsen", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "letter", "published": "2020-08-08", "journal": {"title": "Lancet", "issn": "1474-547X", "issn-l": "0140-6736", "volume": "396", "issue": "10248", "pages": "e16"}, "abstract": null, "doi": "10.1016/S0140-6736(20)31674-3", "pmid": "32771111", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31674-3"}], "notes": [], "created": "2020-11-18T17:16:56.095Z", "modified": "2020-12-11T12:51:30.151Z"}, {"entity": "publication", "iuid": "0c0569b2f3b942bd91e0c502e055ab57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c0569b2f3b942bd91e0c502e055ab57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c0569b2f3b942bd91e0c502e055ab57"}}, "title": "COVID-19-a very visible pandemic - Author's reply.", "authors": [{"family": "Giesecke", "given": "Johan", "initials": "J"}], "type": "letter", "published": "2020-08-08", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "396", "issue": "10248", "pages": "e20", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)31677-9", "pmid": "32771115", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31677-9"}], "notes": [], "created": "2020-12-07T13:33:42.158Z", "modified": "2020-12-07T13:33:42.170Z"}, {"entity": "publication", "iuid": "608402be419043abb6ab5e52ee0617a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/608402be419043abb6ab5e52ee0617a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/608402be419043abb6ab5e52ee0617a0"}}, "title": "The formidable task of fighting COVID-19 in Sudan.", "authors": [{"family": "Elhadi", "given": "Yasir Ahmed Mohammed", "initials": "YAM"}, {"family": "Adebisi", "given": "Yusuff Adebayo", "initials": "YA"}, {"family": "Hassan", "given": "Khlood Fathi", "initials": "KF"}, {"family": "Mohammed", "given": "Salma Elmukashfi Eltaher", "initials": "SEE"}, {"family": "Lin", "given": "Xu", "initials": "X"}, {"family": "Lucero-Prisno Iii", "given": "Don Eliseo", "initials": "DE"}], "type": "journal article", "published": "2020-08-07", "journal": {"title": "Pan Afr Med J", "issn": "1937-8688", "issn-l": null, "volume": "35", "issue": "Suppl 2", "pages": "137"}, "abstract": "Commentary\r\nSudan is facing a formidable task of fighting COVID-19. The country is suddenly challenged by this health issue that will test its path towards peace, stability, and development. The fragile task of handling COVID-19 epidemic in Sudan is brought about by several factors such as the weak healthcare system and political conflicts, that have been intertwined with the recent regime. Even before the COVID-19 pandemic, there was already high unemployment, soaring inflation and lack of social protection and safety nets for its populace. The government has been trying its best to address the pandemic, however, much still needs to be done. Neglecting Sudan by the international community in terms of support towards containment of COVID-19 has grievous implications for transition out of military dictatorship and efforts to curb the pandemic globally. As no country is safe if all is not safe. It is essential that Sudan should leverage on innovations, country-compatible measures, and other tailor-made strategies for effective responses.", "doi": "10.11604/pamj.supp.2020.35.137.24984", "pmid": "33193952", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "PAMJ-35-2-137"}, {"db": "pmc", "key": "PMC7608774"}], "notes": [], "created": "2020-11-30T16:14:57.847Z", "modified": "2020-12-11T12:51:48.786Z"}, {"entity": "publication", "iuid": "7a2b0ec035284b22995f88d44590c3be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a2b0ec035284b22995f88d44590c3be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a2b0ec035284b22995f88d44590c3be"}}, "title": "Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients.", "authors": [{"family": "Stebbing", "given": "Justin", "initials": "J"}, {"family": "Krishnan", "given": "Venkatesh", "initials": "V"}, {"family": "de Bono", "given": "Stephanie", "initials": "S"}, {"family": "Ottaviani", "given": "Silvia", "initials": "S"}, {"family": "Casalini", "given": "Giacomo", "initials": "G"}, {"family": "Richardson", "given": "Peter J", "initials": "PJ"}, {"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Lauschke", "given": "Volker M", "initials": "VM"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Youhanna", "given": "Sonia", "initials": "S"}, {"family": "Tan", "given": "Yee-Joo", "initials": "YJ"}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Sarasini", "given": "Antonella", "initials": "A"}, {"family": "Terres", "given": "Jorge A Ross", "initials": "JAR"}, {"family": "Nickoloff", "given": "Brian J", "initials": "BJ"}, {"family": "Higgs", "given": "Richard E", "initials": "RE"}, {"family": "Rocha", "given": "Guilherme", "initials": "G"}, {"family": "Byers", "given": "Nicole L", "initials": "NL"}, {"family": "Schlichting", "given": "Douglas E", "initials": "DE"}, {"family": "Nirula", "given": "Ajay", "initials": "A"}, {"family": "Cardoso", "given": "Anabela", "initials": "A"}, {"family": "Corbellino", "given": "Mario", "initials": "M"}, {"family": "Sacco Baricitinib Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-07", "journal": {"title": "EMBO Mol Med", "issn": "1757-4684", "volume": "12", "issue": "8", "pages": "e12697", "issn-l": "1757-4676"}, "abstract": "Baricitinib is an oral Janus kinase (JAK)1/JAK2 inhibitor approved for the treatment of rheumatoid arthritis (RA) that was independently predicted, using artificial intelligence (AI) algorithms, to be useful for COVID-19 infection via proposed anti-cytokine effects and as an inhibitor of host cell viral propagation. We evaluated the in vitro pharmacology of baricitinib across relevant leukocyte subpopulations coupled to its in vivo pharmacokinetics and showed it inhibited signaling of cytokines implicated in COVID-19 infection. We validated the AI-predicted biochemical inhibitory effects of baricitinib on human numb-associated kinase (hNAK) members measuring nanomolar affinities for AAK1, BIKE, and GAK. Inhibition of NAKs led to reduced viral infectivity with baricitinib using human primary liver spheroids. These effects occurred at exposure levels seen clinically. In a case series of patients with bilateral COVID-19 pneumonia, baricitinib treatment was associated with clinical and radiologic recovery, a rapid decline in SARS-CoV-2 viral load, inflammatory markers, and IL-6 levels. Collectively, these data support further evaluation of the anti-cytokine and anti-viral activity of baricitinib and support its assessment in randomized trials in hospitalized COVID-19 patients.", "doi": "10.15252/emmm.202012697", "pmid": "32473600", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7300657"}], "notes": [], "created": "2020-11-25T09:23:21.591Z", "modified": "2021-02-26T08:45:03.060Z"}, {"entity": "publication", "iuid": "145941fb72144cf3ae765c4b162cb89a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/145941fb72144cf3ae765c4b162cb89a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/145941fb72144cf3ae765c4b162cb89a"}}, "title": "Genetic and Phenotypic Evidence for the Causal Relationship Between Aging and COVID-19", "authors": [{"family": "Ying", "given": "Kejun", "initials": "K"}, {"family": "Zhai", "given": "Ranran", "initials": "R"}, {"family": "Pyrkov", "given": "Timothy V", "initials": "TV"}, {"family": "Mariotti", "given": "Marco", "initials": "M"}, {"family": "Fedichev", "given": "Peter O", "initials": "PO"}, {"family": "Shen", "given": "Xia", "initials": "X"}, {"family": "Gladyshev", "given": "Vadim N", "initials": "VN"}], "type": "posted-content", "published": "2020-08-07", "journal": {"title": "", "issn": null, "volume": null, "issue": null, "pages": null, "issn-l": null}, "abstract": null, "doi": "10.1101/2020.08.06.20169854", "pmid": null, "labels": {"Category: Genomics & transcriptomics": null, "Type: Preprint": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://www.medrxiv.org/content/10.1101/2020.08.06.20169854v2.supplementary-material", "description": "Supplementary information contains information on publicly available data sources used, instruments used, data on loci associated with risk factors, and genetic correlations between lifespan-related traits and COVID-19"}, {"db": "UK Biobank", "key": "Data used from biobank under Application Number 21988", "description": null}], "notes": [], "created": "2021-06-09T19:33:49.695Z", "modified": "2021-11-18T08:40:25.074Z"}, {"entity": "publication", "iuid": "1c5f8d11e66f46b1828d45f505b2919b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1c5f8d11e66f46b1828d45f505b2919b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1c5f8d11e66f46b1828d45f505b2919b"}}, "title": "Early Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19.", "authors": [{"family": "Alexander", "given": "Jan", "initials": "J"}, {"family": "Tinkov", "given": "Alexey", "initials": "A"}, {"family": "Strand", "given": "Tor A", "initials": "TA"}, {"family": "Alehagen", "given": "Urban", "initials": "U"}, {"family": "Skalny", "given": "Anatoly", "initials": "A"}, {"family": "Aaseth", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2020-08-07", "journal": {"title": "Nutrients", "issn": "2072-6643", "volume": "12", "issue": "8", "issn-l": null}, "abstract": "The novel coronavirus infection (COVID-19) conveys a serious threat globally to health and economy because of a lack of vaccines and specific treatments. A common factor for conditions that predispose for serious progress is a low-grade inflammation, e.g., as seen in metabolic syndrome, diabetes, and heart failure, to which micronutrient deficiencies may contribute. The aim of the present article was to explore the usefulness of early micronutrient intervention, with focus on zinc, selenium, and vitamin D, to relieve escalation of COVID-19.\n\nWe conducted an online search for articles published in the period 2010-2020 on zinc, selenium, and vitamin D, and corona and related virus infections.\n\nThere were a few studies providing direct evidence on associations between zinc, selenium, and vitamin D, and COVID-19. Adequate supply of zinc, selenium, and vitamin D is essential for resistance to other viral infections, immune function, and reduced inflammation. Hence, it is suggested that nutrition intervention securing an adequate status might protect against the novel coronavirus SARS-CoV-2 (Severe Acute Respiratory Syndrome - coronavirus-2) and mitigate the course of COVID-19.\n\nWe recommended initiation of adequate supplementation in high-risk areas and/or soon after the time of suspected infection with SARS-CoV-2. Subjects in high-risk groups should have high priority as regards this nutritive adjuvant therapy, which should be started prior to administration of specific and supportive medical measures.", "doi": "10.3390/nu12082358", "pmid": "32784601", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "nu12082358"}, {"db": "pmc", "key": "PMC7468884"}], "notes": [], "created": "2020-11-30T08:41:02.999Z", "modified": "2020-11-30T08:41:03.023Z"}, {"entity": "publication", "iuid": "c6ecdfad60ee4db38c12af7152621b7e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c6ecdfad60ee4db38c12af7152621b7e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c6ecdfad60ee4db38c12af7152621b7e"}}, "title": "COVID-19 salivary signature: diagnostic and research opportunities.", "authors": [{"family": "Sapkota", "given": "Dipak", "initials": "D"}, {"family": "S\u00f8land", "given": "Tine Merete", "initials": "TM"}, {"family": "Galtung", "given": "Hilde Kanli", "initials": "HK"}, {"family": "Sand", "given": "Lars Peter", "initials": "LP"}, {"family": "Giannecchini", "given": "Simone", "initials": "S"}, {"family": "To", "given": "Kelvin K W", "initials": "KKW"}, {"family": "Mendes-Correa", "given": "Maria Cassia", "initials": "MC"}, {"family": "Giglio", "given": "Daniel", "initials": "D"}, {"family": "Hass\u00e9us", "given": "Bengt", "initials": "B"}, {"family": "Braz-Silva", "given": "Paulo Henrique", "initials": "PH"}], "type": "journal article", "published": "2020-08-07", "journal": {"title": "J Clin Pathol", "issn": "1472-4146", "volume": null, "issue": null, "issn-l": null}, "abstract": "The COVID-19 (caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)) epidemic started in Wuhan (Hubei Province, China) in mid-December 2019 and quickly spread across the world as a pandemic. As a key to tracing the disease and to implement strategies aimed at breaking the chain of disease transmission, extensive testing for SARS-CoV-2 was suggested. Although nasopharyngeal/oropharyngeal swabs are the most commonly used biological samples for SARS-CoV-2 diagnosis, they have a number of limitations related to sample collection and healthcare personnel safety. In this context, saliva is emerging as a promising alternative to nasopharyngeal/oropharyngeal swabs for COVID-19 diagnosis and monitoring. Saliva collection, being a non-invasive approach with possibility for self-collection, circumvents to a great extent the limitations associated with the use of nasopharyngeal/oropharyngeal swabs. In addition, various salivary biomarkers including the salivary metabolomics offer a high promise to be useful for better understanding of COVID-19 and possibly in the identification of patients with various degrees of severity, including asymptomatic carriers. This review summarises the clinical and scientific basis for the potential use of saliva for COVID-19 diagnosis and disease monitoring. Additionally, we discuss saliva-based biomarkers and their potential clinical and research applications related to COVID-19.", "doi": "10.1136/jclinpath-2020-206834", "pmid": "32769214", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jclinpath-2020-206834"}], "notes": [], "created": "2020-11-30T08:42:54.384Z", "modified": "2020-11-30T08:42:54.407Z"}, {"entity": "publication", "iuid": "25d7fe6e2f794d6297df25b9325629dc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/25d7fe6e2f794d6297df25b9325629dc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/25d7fe6e2f794d6297df25b9325629dc"}}, "title": "COVID-19 and immunological regulations - from basic and translational aspects to clinical implications.", "authors": [{"family": "Sch\u00f6n", "given": "Michael P", "initials": "MP"}, {"family": "Berking", "given": "Carola", "initials": "C"}, {"family": "Biedermann", "given": "Tilo", "initials": "T"}, {"family": "Buhl", "given": "Timo", "initials": "T"}, {"family": "Erpenbeck", "given": "Luise", "initials": "L"}, {"family": "Eyerich", "given": "Kilian", "initials": "K"}, {"family": "Eyerich", "given": "Stefanie", "initials": "S"}, {"family": "Ghoreschi", "given": "Kamran", "initials": "K"}, {"family": "Goebeler", "given": "Matthias", "initials": "M"}, {"family": "Ludwig", "given": "Ralf J", "initials": "RJ"}, {"family": "Sch\u00e4kel", "given": "Knut", "initials": "K"}, {"family": "Schilling", "given": "Bastian", "initials": "B"}, {"family": "Schlapbach", "given": "Christoph", "initials": "C"}, {"family": "Stary", "given": "Georg", "initials": "G"}, {"family": "von Stebut", "given": "Esther", "initials": "E"}, {"family": "Steinbrink", "given": "Kerstin", "initials": "K"}], "type": "journal article", "published": "2020-08-06", "journal": {"title": "J Dtsch Dermatol Ges", "issn": "1610-0387", "volume": null, "issue": null, "issn-l": "1610-0379"}, "abstract": "The COVID-19 pandemic caused by SARS-CoV-2 has far-reaching direct and indirect medical consequences. These include both the course and treatment of diseases. It is becoming increasingly clear that infections with SARS-CoV-2 can cause considerable immunological alterations, which particularly also affect pathogenetically and/or therapeutically relevant factors. Against this background we summarize here the current state of knowledge on the interaction of SARS-CoV-2/COVID-19 with mediators of the acute phase of inflammation (TNF, IL-1, IL-6), type 1 and type 17 immune responses (IL-12, IL-23, IL-17, IL-36), type 2 immune reactions (IL-4, IL-13, IL-5, IL-31, IgE), B-cell immunity, checkpoint regulators (PD-1, PD-L1, CTLA4), and orally druggable signaling pathways (JAK, PDE4, calcineurin). In addition, we discuss in this context non-specific immune modulation by glucocorticosteroids, methotrexate, antimalarial drugs, azathioprine, dapsone, mycophenolate mofetil and fumaric acid esters, as well as neutrophil granulocyte-mediated innate immune mechanisms. From these recent findings we derive possible implications for the therapeutic modulation of said immunological mechanisms in connection with SARS-CoV-2/COVID-19. Although, of course, the greatest care should be taken with patients with immunologically mediated diseases or immunomodulating therapies, it appears that many treatments can also be carried out during the COVID-19 pandemic; some even appear to alleviate COVID-19.", "doi": "10.1111/ddg.14169", "pmid": "32761894", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7436872"}], "notes": [], "created": "2020-11-26T12:16:43.799Z", "modified": "2020-11-30T08:42:56.759Z"}, {"entity": "publication", "iuid": "36ec715ded154e0d82da66e25352c506", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/36ec715ded154e0d82da66e25352c506.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/36ec715ded154e0d82da66e25352c506"}}, "title": "International variation in the management of severe COVID-19 patients.", "authors": [{"family": "Azoulay", "given": "Elie", "initials": "E"}, {"family": "de Waele", "given": "Jan", "initials": "J"}, {"family": "Ferrer", "given": "Ricard", "initials": "R"}, {"family": "Staudinger", "given": "Thomas", "initials": "T"}, {"family": "Borkowska", "given": "Marta", "initials": "M"}, {"family": "Povoa", "given": "Pedro", "initials": "P"}, {"family": "Iliopoulou", "given": "Katerina", "initials": "K"}, {"family": "Artigas", "given": "Antonio", "initials": "A"}, {"family": "Schaller", "given": "Stefan J", "initials": "SJ"}, {"family": "Shankar-Hari", "given": "Manu", "initials": "M"}, {"family": "Pellegrini", "given": "Mariangela", "initials": "M"}, {"family": "Darmon", "given": "Michael", "initials": "M"}, {"family": "Kesecioglu", "given": "Jozef", "initials": "J"}, {"family": "Cecconi", "given": "Maurizio", "initials": "M"}], "type": "journal article", "published": "2020-08-05", "journal": {"title": "Crit Care", "issn": "1466-609X", "volume": "24", "issue": "1", "pages": "486", "issn-l": "1364-8535"}, "abstract": "There is little evidence to support the management of severe COVID-19 patients.\n\nTo document this variation in practices, we performed an online survey (April 30-May 25, 2020) on behalf of the European Society of Intensive Care Medicine (ESICM). A case vignette was sent to ESICM members. Questions investigated practices for a previously healthy 39-year-old patient presenting with severe hypoxemia from COVID-19 infection.\n\nA total of 1132 ICU specialists (response rate 20%) from 85 countries (12 regions) responded to the survey. The survey provides information on the heterogeneity in patient's management, more particularly regarding the timing of ICU admission, the first line oxygenation strategy, optimization of management, and ventilatory settings in case of refractory hypoxemia. Practices related to antibacterial, antiviral, and anti-inflammatory therapies are also investigated.\n\nThere are important practice variations in the management of severe COVID-19 patients, including differences at regional and individual levels. Large outcome studies based on multinational registries are warranted.", "doi": "10.1186/s13054-020-03194-w", "pmid": "32758266", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13054-020-03194-w"}, {"db": "pmc", "key": "PMC7403819"}], "notes": [], "created": "2020-12-07T15:44:14.482Z", "modified": "2021-02-26T08:45:48.038Z"}, {"entity": "publication", "iuid": "37c9a6ce93fa4bbba28a966ae11c4157", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/37c9a6ce93fa4bbba28a966ae11c4157.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/37c9a6ce93fa4bbba28a966ae11c4157"}}, "title": "High seroprevalence of SARS-CoV-2 in elderly care employees in Sweden.", "authors": [{"family": "Lindahl", "given": "Johanna F", "initials": "JF"}, {"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Esmaeilzadeh", "given": "Mouna", "initials": "M"}, {"family": "Olsen", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Winter", "given": "Reidar", "initials": "R"}, {"family": "Amer", "given": "Stefan", "initials": "S"}, {"family": "Moln\u00e1r", "given": "Christian", "initials": "C"}, {"family": "Svalberg", "given": "Ann", "initials": "A"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "journal article", "published": "2020-08-05", "journal": {"title": "Infect Ecol Epidemiol", "issn": "2000-8686", "issn-l": "2000-8686", "volume": "10", "issue": "1", "pages": "1789036"}, "abstract": "The COVID-19 pandemic is growing and spread in the Swedish elderly care system during April 2020. The increasing number of employees on sick-leave due to COVID-19 created severe logistic problems. Some elderly care homes therefore started to screen their personnel to secure the safety of the elderly and to avoid unnecessary quarantine of potentially immune employees. Secondary data from a screening with a COVID-19 rapid test for detection of SARS-CoV-2-specific IgM and IgG of 1,005 employees in 22 elderly care homes in Stockholm, Sweden, were analyzed. Seropositive employees were found in 21 out of the 22 care homes. In total, 23% (231/1,005) of the employees tested positive for antibodies against SARS-CoV-2, and 14.3% (144/1,005) were found positive for IgM (either alone or combined with IgG), indicating recent or present infection. Of those that tested seropositive, 46.5% did not report any clinical symptoms, indicating pre- or asymptomatic infections. Reported symptoms with the highest correlation with seropositivity were fever and loss of smell and taste. These results suggest that antibody testing of employees in elderly care homes is valuable for surveillance of disease development and a crucial screening tool in the effort to decrease the death toll in this pandemic.", "doi": "10.1080/20008686.2020.1789036", "pmid": "32939231", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Serology": null}, "xrefs": [{"db": "URL", "key": "https://doi.org/10.1080/20008686.2020.1789036", "description": "Serological responses of 1,005 employees to SARS-CoV-2 at 22 different elderly care homes in Stockholm"}], "notes": [], "created": "2020-10-30T11:59:27.014Z", "modified": "2021-02-26T08:46:49.351Z"}, {"entity": "publication", "iuid": "e0b776a8100d4f16ba4500c1a3f97b17", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e0b776a8100d4f16ba4500c1a3f97b17.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e0b776a8100d4f16ba4500c1a3f97b17"}}, "title": "Does COVID-19 teach us anything for our future?", "authors": [{"family": "Ralph Edwards", "given": "Ivor", "initials": "I"}, {"family": "Lindquist", "given": "Marie", "initials": "M"}], "type": "editorial", "published": "2020-08-04", "journal": {"title": "Int J Risk Saf Med", "issn": "1878-6847", "volume": "31", "issue": "3", "pages": "107-109", "issn-l": null}, "abstract": null, "doi": "10.3233/JRS-201006", "pmid": "32741780", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "JRS201006"}], "notes": [], "created": "2020-12-07T16:04:51.880Z", "modified": "2020-12-07T16:04:51.890Z"}, {"entity": "publication", "iuid": "53523ecc594e44228bfa5d7a00454b93", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53523ecc594e44228bfa5d7a00454b93.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53523ecc594e44228bfa5d7a00454b93"}}, "title": "Charting a \"Green Path\" for Recovery from COVID-19.", "authors": [{"family": "Mukanjari", "given": "Samson", "initials": "S"}, {"family": "Sterner", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2020-08-04", "journal": {"title": "Environ Resour Econ (Dordr)", "issn": "0924-6460", "volume": null, "issue": null, "pages": "1-29", "issn-l": null}, "abstract": "Should the economic recovery from the 2019 novel coronavirus disease (COVID-19) be green? The current crisis is so severe that we should not take the answer for granted. It requires serious thought and we start by reviewing some arguments for and against a green approach. A crucial element is of course to see how different industries fare in the current crisis. Our empirical contribution is to examine daily stock returns for firms from the STOXX Europe 600 index. We find that firms with higher carbon intensities experienced significantly large decreases in stock values particularly those within the crude petroleum extraction, air transport and coke and refined petroleum industries. Our tentative conclusion is that efforts to revitalize the economy should avoid subsidizing stranded assets and instead target the industries of the future. However, identifying these will not necessarily be easy. We find, for example, that having an official ESG \"climate change policy\" has no effect on firm performance during the pandemic. We suggest possible ways of designing a new form of more informative index.", "doi": "10.1007/s10640-020-00479-0", "pmid": "32836858", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "479"}, {"db": "pmc", "key": "PMC7399619"}], "notes": [], "created": "2020-12-07T10:38:46.542Z", "modified": "2020-12-07T10:38:46.565Z"}, {"entity": "publication", "iuid": "a218165be69a45edb93660bd7b6cfe16", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a218165be69a45edb93660bd7b6cfe16.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a218165be69a45edb93660bd7b6cfe16"}}, "title": "Autoimmune Encephalitis Presenting with Acute Excited Catatonia in a 40-Year-Old Male Patient with Covid-19", "authors": [{"family": "Mulder", "given": "Jan", "initials": "J"}, {"family": "Feresiadou", "given": "Amalia", "initials": "A"}, {"family": "Fallmar", "given": "David", "initials": "D"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}, {"family": "Virhammar", "given": "Johan", "initials": "J"}, {"family": "Rasmusson", "given": "Annica", "initials": "A"}, {"family": "Rostami", "given": "Elham", "initials": "E"}, {"family": "Kumlien", "given": "Eva", "initials": "E"}, {"family": "Cunningham", "given": "Janet Lynn", "initials": "JL"}], "type": "posted-content", "published": "2020-08-04", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.07.23.20160770", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-08T07:05:15.963Z", "modified": "2021-02-26T08:45:48.537Z"}, {"entity": "publication", "iuid": "fb5f4bebc9124a8794bd30fa72135cff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb5f4bebc9124a8794bd30fa72135cff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb5f4bebc9124a8794bd30fa72135cff"}}, "title": "Tocilizumab shortens time on mechanical ventilation and length of hospital stay in patients with severe COVID-19: a retrospective cohort study.", "authors": [{"family": "Eimer", "given": "J", "initials": "J"}, {"family": "Vesterbacka", "given": "J", "initials": "J"}, {"family": "Svensson", "given": "A-K", "initials": "A"}, {"family": "Stojanovic", "given": "B", "initials": "B"}, {"family": "Wagrell", "given": "C", "initials": "C"}, {"family": "S\u00f6nnerborg", "given": "A", "initials": "A"}, {"family": "Nowak", "given": "P", "initials": "P"}], "type": "letter", "published": "2020-08-03", "journal": {"title": "J Intern Med", "issn": "1365-2796", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1111/joim.13162", "pmid": "32744399", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pmc", "key": "PMC7436415"}], "notes": [], "created": "2020-12-04T08:37:40.803Z", "modified": "2021-02-26T08:45:03.368Z"}, {"entity": "publication", "iuid": "bc6e19c1df8142dfaa90075bd10b585e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bc6e19c1df8142dfaa90075bd10b585e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bc6e19c1df8142dfaa90075bd10b585e"}}, "title": "Misleading media coverage of Sweden's response to covid-19.", "authors": [{"family": "Irwin", "given": "Rachel E", "initials": "RE"}], "type": "letter", "published": "2020-08-03", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "370", "issue": null, "pages": "m3031", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m3031", "pmid": "32747388", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-07T16:00:57.583Z", "modified": "2023-01-13T13:50:00.714Z"}, {"entity": "publication", "iuid": "62f5193eb1274e2598aa5bb32f854c43", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/62f5193eb1274e2598aa5bb32f854c43.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/62f5193eb1274e2598aa5bb32f854c43"}}, "title": "Social determinants of health and inequalities in COVID-19.", "authors": [{"family": "Burstr\u00f6m", "given": "Bo", "initials": "B"}, {"family": "Tao", "given": "Wenjing", "initials": "W"}], "type": "journal article", "published": "2020-08-01", "journal": {"title": "Eur J Public Health", "issn": "1464-360X", "issn-l": "1101-1262", "volume": "30", "issue": "4", "pages": "617-618"}, "abstract": null, "doi": "10.1093/eurpub/ckaa095", "pmid": "32638998", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5868718"}, {"db": "pmc", "key": "PMC7454505"}], "notes": [], "created": "2020-12-04T08:34:26.857Z", "modified": "2021-01-25T10:28:30.704Z"}, {"entity": "publication", "iuid": "cc1abb039bfa44da943ee142c71545d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/cc1abb039bfa44da943ee142c71545d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/cc1abb039bfa44da943ee142c71545d0"}}, "title": "\ufeffEASAPS/ESPRAS Considerations in getting back to work in Plastic Surgery with the COVID-19 Pandemic - A European point of view.", "authors": [{"family": "van Heijningen", "given": "Ivar", "initials": "I"}, {"family": "Frank", "given": "Konstantin", "initials": "K"}, {"family": "Almeida", "given": "Francisco", "initials": "F"}, {"family": "B\u00f6sch", "given": "Urs", "initials": "U"}, {"family": "Bradic", "given": "Nicola", "initials": "N"}, {"family": "Costa", "given": "Horacio", "initials": "H"}, {"family": "Demirdover", "given": "Cenk", "initials": "C"}, {"family": "Henley", "given": "Mark", "initials": "M"}, {"family": "Kamolz", "given": "Lars Peter", "initials": "LP"}, {"family": "Rouif", "given": "Michel", "initials": "M"}, {"family": "Spendel", "given": "Stephan", "initials": "S"}, {"family": "Russe-Wilflingseder", "given": "Katharina", "initials": "K"}, {"family": "Stark", "given": "Birgit", "initials": "B"}, {"family": "Giunta", "given": "Riccardo E", "initials": "RE"}, {"family": "Parreira", "given": "Jose Carlos", "initials": "JC"}, {"family": "Zic", "given": "Rado", "initials": "R"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Handchir Mikrochir Plast Chir", "issn": "1439-3980", "volume": "52", "issue": "4", "pages": "257-264", "issn-l": "0722-1819"}, "abstract": "The aim of this paper is to summarize the results of a consensus process and a European webinar of the two societies, European Association of Societies of Aesthetic Surgery (EASAPS) and the European Society of Plastic, Reconstructive and Aesthetic Societies (ESPRAS) on what is considered safe practice based on the scientific knowledge we have today. This review of the current situations gives considerations which have to be taken into account when getting back to work in plastic surgery with COVID-19 in Europe. At all times, one should be familiar the local and regional infection rates in the community, with particular emphasis on the emergence of second and third waves of the pandemic. Due to the fast-evolving nature of the COVID-19 pandemic the recommendations aim to be rather considerations than fixed guidelines and might need to be revised in near future.", "doi": "10.1055/a-1175-4169", "pmid": "32422664", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-25T08:30:59.859Z", "modified": "2020-11-30T09:07:53.328Z"}, {"entity": "publication", "iuid": "0d301750f52348f487fee1959c1b870b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d301750f52348f487fee1959c1b870b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d301750f52348f487fee1959c1b870b"}}, "title": "Vascular Surgery in Unreal Times.", "authors": [{"family": "Eilenberg", "given": "Wolf", "initials": "W"}, {"family": "Busch", "given": "Albert", "initials": "A"}, {"family": "Wagenh\u00e4user", "given": "Markus", "initials": "M"}, {"family": "Giannoukas", "given": "Athanasios", "initials": "A"}, {"family": "Wanhainen", "given": "Anders", "initials": "A"}, {"family": "Neumayer", "given": "Christoph", "initials": "C"}, {"family": "Haulon", "given": "Stephan", "initials": "S"}], "type": "editorial", "published": "2020-08-00", "journal": {"title": "Eur J Vasc Endovasc Surg", "issn": "1532-2165", "volume": "60", "issue": "2", "pages": "167-168", "issn-l": "1078-5884"}, "abstract": "Editorial", "doi": "10.1016/j.ejvs.2020.05.031", "pmid": "32605851", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1078-5884(20)30453-6"}, {"db": "pmc", "key": "PMC7320915"}], "notes": [], "created": "2020-11-22T09:36:23.824Z", "modified": "2020-12-08T15:23:07.202Z"}, {"entity": "publication", "iuid": "6ac885a2ae224f9b8751ef2a27f87f3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6ac885a2ae224f9b8751ef2a27f87f3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6ac885a2ae224f9b8751ef2a27f87f3d"}}, "title": "Using the prone position could help to combat the development of fast hypoxia in some patients with COVID-19.", "authors": [{"family": "Lindahl", "given": "Sten G E", "initials": "SGE"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "volume": "109", "issue": "8", "pages": "1539-1544", "issn-l": null}, "abstract": "The world is facing an explosive COVID-19 pandemic. Some cases rapidly develop deteriorating lung function, which causes deep hypoxaemia and requires urgent treatment. Many centres have started treating patients in the prone position, and oxygenation has improved considerably in some cases. Questions have been raised regarding the mechanisms behind this. The mini review provides some insights into the role of supine and prone body positions and summarises the latest understanding of the responsible mechanisms. The scope for discussion is outside the neonatal period and entirely based on experimental and clinical experiences related to adults. The human respiratory system is a complex interplay of many different variables. Therefore, this mini review has prioritised previous and ongoing research to find explanations based on three scientific areas: gravity, lung structure and fractal geometry and vascular regulation. It concludes that gravity is one of the variables responsible for ventilation/perfusion matching but in concert with lung structure and fractal geometry, ventilation and regulation of lung vascular tone. Since ventilation distribution does not change between supine and prone positions, the higher expression of nitric oxide in dorsal lung vessels than in ventral vessels is likely to be the most important mechanism behind enhanced oxygenation in the prone position.", "doi": "10.1111/apa.15382", "pmid": "32484966", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7301016"}], "notes": [], "created": "2020-11-25T08:08:41.192Z", "modified": "2020-11-30T09:02:31.821Z"}, {"entity": "publication", "iuid": "27bae21f98f64e098fe22a4be2b9d608", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/27bae21f98f64e098fe22a4be2b9d608.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/27bae21f98f64e098fe22a4be2b9d608"}}, "title": "Updated rapid risk assessment from ECDC on coronavirus disease (COVID-19) pandemic in the EU/EEA and the UK: resurgence of cases.", "authors": [{"family": "Eurosurveillance editorial team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "32", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.32.2008131", "pmid": "32794445", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7427298"}], "notes": [], "created": "2020-12-07T13:22:35.411Z", "modified": "2020-12-07T13:22:35.421Z"}, {"entity": "publication", "iuid": "b9c70b65997f4554a82535ca0072b2b9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9c70b65997f4554a82535ca0072b2b9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9c70b65997f4554a82535ca0072b2b9"}}, "title": "The COVID-19 pandemic and the Swedish strategy: Epidemiology and postmodernism.", "authors": [{"family": "Lindstr\u00f6m", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "SSM Popul Health", "issn": "2352-8273", "volume": "11", "issue": null, "pages": "100643", "issn-l": null}, "abstract": "The aim is to outline the underlying epidemiological thinking and mentality in post-materialist and postmodern Sweden behind the Swedish strategy. The aim is not to investigate the handling of the pandemic in Sweden in the long-run. Overconfidence in herd immunity, overconfidence in individual responsibility in a pandemic needing community-centered approaches, overconfidence in evidence-based medicine and neglect to coordinate with the WHO and other countries may be associated with post-materialist values and postmodernism including opposition against modern authority, rationality and science, and also an anti-traditionalist stance towards older generations. COVID-19 epidemiology and postmodernism may be a dangerous combination.", "doi": "10.1016/j.ssmph.2020.100643", "pmid": "32885019", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "S2352-8273(20)30280-9"}, {"db": "pii", "key": "100643"}, {"db": "pmc", "key": "PMC7453138"}], "notes": [], "created": "2020-12-06T07:29:56.517Z", "modified": "2020-12-06T07:29:56.540Z"}, {"entity": "publication", "iuid": "77dbed03c6fc462eb917dc197ce883ea", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/77dbed03c6fc462eb917dc197ce883ea.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/77dbed03c6fc462eb917dc197ce883ea"}}, "title": "Steroid-Responsive Encephalitis in Coronavirus Disease 2019.", "authors": [{"family": "Pilotto", "given": "Andrea", "initials": "A"}, {"family": "Odolini", "given": "Silvia", "initials": "S"}, {"family": "Masciocchi", "given": "Stefano", "initials": "S"}, {"family": "Comelli", "given": "Agnese", "initials": "A"}, {"family": "Volonghi", "given": "Irene", "initials": "I"}, {"family": "Gazzina", "given": "Stefano", "initials": "S"}, {"family": "Nocivelli", "given": "Sara", "initials": "S"}, {"family": "Pezzini", "given": "Alessandro", "initials": "A"}, {"family": "Foc\u00e0", "given": "Emanuele", "initials": "E"}, {"family": "Caruso", "given": "Arnaldo", "initials": "A"}, {"family": "Leonardi", "given": "Matilde", "initials": "M"}, {"family": "Pasolini", "given": "Maria P", "initials": "MP"}, {"family": "Gasparotti", "given": "Roberto", "initials": "R"}, {"family": "Castelli", "given": "Francesco", "initials": "F"}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Padovani", "given": "Alessandro", "initials": "A"}], "type": "case reports", "published": "2020-08-00", "journal": {"title": "Ann Neurol", "issn": "1531-8249", "volume": "88", "issue": "2", "pages": "423-427", "issn-l": null}, "abstract": "Coronavirus disease 2019 (COVID-19) infection has the potential for targeting the central nervous system, and several neurological symptoms have been described in patients with severe respiratory distress. Here, we described the case of a 60-year-old patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection but only mild respiratory abnormalities who developed an akinetic mutism attributable to encephalitis. Magnetic resonance imaging was negative, whereas electroencephalography showed generalized theta slowing. Cerebrospinal fluid analyses during the acute stage were negative for SARS-CoV-2, positive for pleocytosis and hyperproteinorrachia, and showed increased interleukin-8 and tumor necrosis factor-\u03b1 concentrations. Other infectious or autoimmune disorders were excluded. A progressive clinical improvement along with a reduction of cerebrospinal fluid parameters was observed after high-dose steroid treatment, thus arguing for an inflammatory-mediated brain involvement related to COVID-19. ANN NEUROL 2020;88:423-427.", "doi": "10.1002/ana.25783", "pmid": "32418288", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7276848"}], "notes": [], "created": "2020-12-10T08:55:43.469Z", "modified": "2021-02-26T08:45:48.330Z"}, {"entity": "publication", "iuid": "2dec25cb865b4377aafe550af4a49d56", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2dec25cb865b4377aafe550af4a49d56.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2dec25cb865b4377aafe550af4a49d56"}}, "title": "Sports Health During the SARS-Cov-2 Pandemic.", "authors": [{"family": "Timpka", "given": "Toomas", "initials": "T"}], "type": "letter", "published": "2020-08-00", "journal": {"title": "Sports Med", "issn": "1179-2035", "volume": "50", "issue": "8", "pages": "1413-1416", "issn-l": null}, "abstract": null, "doi": "10.1007/s40279-020-01288-7", "pmid": "32361898", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40279-020-01288-7"}, {"db": "pmc", "key": "PMC7195617"}], "notes": [], "created": "2020-12-10T07:24:46.451Z", "modified": "2020-12-10T07:24:46.473Z"}, {"entity": "publication", "iuid": "e2b2172a254943d9818aa55345a77951", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2b2172a254943d9818aa55345a77951.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2b2172a254943d9818aa55345a77951"}}, "title": "Society of Robotic Surgery review: recommendations regarding the risk of COVID-19 transmission during minimally invasive surgery.", "authors": [{"family": "Porter", "given": "James", "initials": "J"}, {"family": "Blau", "given": "Elliot", "initials": "E"}, {"family": "Gharagozloo", "given": "Farid", "initials": "F"}, {"family": "Martino", "given": "Martin", "initials": "M"}, {"family": "Cerfolio", "given": "Robert", "initials": "R"}, {"family": "Duvvuri", "given": "Umamaheswar", "initials": "U"}, {"family": "Caceres", "given": "Aileen", "initials": "A"}, {"family": "Badani", "given": "Ketan", "initials": "K"}, {"family": "Bhayani", "given": "Sam", "initials": "S"}, {"family": "Collins", "given": "Justin", "initials": "J"}, {"family": "Coelho", "given": "Rafael", "initials": "R"}, {"family": "Rocco", "given": "Bernard", "initials": "B"}, {"family": "Wiklund", "given": "Peter", "initials": "P"}, {"family": "Nathan", "given": "Senthil", "initials": "S"}, {"family": "Parra-Davila", "given": "Eduardo", "initials": "E"}, {"family": "Ortiz-Ortiz", "given": "Carlos", "initials": "C"}, {"family": "Maes", "given": "Kris", "initials": "K"}, {"family": "Dasgupta", "given": "Prokar", "initials": "P"}, {"family": "Patel", "given": "Vipul", "initials": "V"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "BJU Int", "issn": "1464-410X", "volume": "126", "issue": "2", "pages": "225-234", "issn-l": "1464-4096"}, "abstract": "To determine the risk of COVID-19 transmission during minimally invasive surgical (MIS) procedures METHODS: Surgical society statements regarding the risk of COVID transmission during MIS procedures were reviewed. In addition, the available literature on COVID-19 and other viral transmission in CO2 pneumoperitoneum, as well as the presence of virus in the plume created by electrocautery during MIS was reviewed. The society recommendations were compared to the available literature on the topic to create our review and recommendations to mitigate COVID-19 transmission.\n\nThe recommendations promulgated by various surgical societies evolved over time as more information became available on COVID-19 transmission. Review of the available literature on the presence of COVID-19 in CO2 pneumoperitoneum was inconclusive. There is no clear evidence of the presence of COVID-19 in plume created by electrocautery. Technologies to reduce CO2 pneumoperitoneum release into the operating room as well as filter viral particles are available and should reduce the exposure risk to operating room personnel.\n\nThere is no clear evidence of COVID-19 virus in the CO2 used during MIS procedures or in the plume created by electrocautery. Until the presence or absence of COVID-19 viral particles has been clearly established, measures to mitigate CO2 and surgical cautery plume release into the operating room should be performed. Further study on the presence of COVID-19 in MIS pneumoperitoneum and cautery plume is needed.", "doi": "10.1111/bju.15105", "pmid": "32383520", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7267386"}], "notes": [], "created": "2020-11-25T07:32:27.293Z", "modified": "2020-12-10T07:40:38.266Z"}, {"entity": "publication", "iuid": "805eae795adb4cc5a630baf15dde1a2e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/805eae795adb4cc5a630baf15dde1a2e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/805eae795adb4cc5a630baf15dde1a2e"}}, "title": "Smell and taste alterations in COVID-19: a cross-sectional analysis of different cohorts.", "authors": [{"family": "Paderno", "given": "Alberto", "initials": "A"}, {"family": "Schreiber", "given": "Alberto", "initials": "A"}, {"family": "Grammatica", "given": "Alberto", "initials": "A"}, {"family": "Raffetti", "given": "Elena", "initials": "E"}, {"family": "Tomasoni", "given": "Michele", "initials": "M"}, {"family": "Gualtieri", "given": "Tommaso", "initials": "T"}, {"family": "Taboni", "given": "Stefano", "initials": "S"}, {"family": "Zorzi", "given": "Silvia", "initials": "S"}, {"family": "Lombardi", "given": "Davide", "initials": "D"}, {"family": "Deganello", "given": "Alberto", "initials": "A"}, {"family": "Redaelli De Zinis", "given": "Luca Oscar", "initials": "LO"}, {"family": "Maroldi", "given": "Roberto", "initials": "R"}, {"family": "Mattavelli", "given": "Davide", "initials": "D"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Int Forum Allergy Rhinol", "issn": "2042-6984", "volume": "10", "issue": "8", "pages": "955-962", "issn-l": "2042-6976"}, "abstract": "Olfactory (OD) and gustatory (GD) dysfunction have been proven to be a typical symptom of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. However, their prevalence in different patient populations still needs to be clarified.\n\nA cross-sectional study was performed from March 27 to April 1, 2020, in Northern Italy. Physicians administered a survey-based questionnaire to SARS-CoV-2-positive patients with the aim of assessing symptoms, focusing on OD and GD. Two groups were studied: group A, patients hospitalized at Azianda Socio Sanitaria Territoriale (ASST) Spedali Civili University Hospital of Brescia; and group B, home-quarantined subjects.\n\nA total of 508 patients were enrolled: 295 in group A and 213 in group B. Mean age \u00b1 standard deviation (SD) was 55 \u00b1 15 years; 56% were men. Overall, OD and GD were present in 56% (95% confidence interval [CI], 51% to 60%) and 63% (95% CI, 59% to 67%) of cases, respectively. In group A, the prevalence of OD and GD was 44% (95% CI, 38% to 50%) and 52% (95% CI, 46% to 58%), respectively. In group B, the prevalence of OD and GD was 72% (95% CI, 65% to 79%) and 79% (95% CI, 73% to 84%), respectively. In the entire cohort, total loss of olfaction and taste was reported in 64% and 60% of cases, respectively. OD and GD occurred as the first symptom in 10% and 11% of cases, respectively; in the remaining cases, they occurred after a mean of 4 \u00b1 3 days following the first symptom. At the time of the questionnaire, complete resolution of OD and GD was reported in 52% and 55% of cases, respectively (mean duration, 9 \u00b1 5 days in both).\n\nOD and GD are more prevalent in home-quarantined subjects, and they are independently associated with younger age and female gender.", "doi": "10.1002/alr.22610", "pmid": "32410386", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7272886"}], "notes": [], "created": "2020-11-25T08:09:58.321Z", "modified": "2021-02-26T08:45:48.417Z"}, {"entity": "publication", "iuid": "e58494e9496644f8818bce57e34e8fc9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e58494e9496644f8818bce57e34e8fc9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e58494e9496644f8818bce57e34e8fc9"}}, "title": "School and pre-school children with type 1 diabetes during Covid-19 quarantine: The synergic effect of parental care and technology.", "authors": [{"family": "Schiaffini", "given": "Riccardo", "initials": "R"}, {"family": "Barbetti", "given": "Fabrizio", "initials": "F"}, {"family": "Rapini", "given": "Novella", "initials": "N"}, {"family": "Inzaghi", "given": "Elena", "initials": "E"}, {"family": "Deodati", "given": "Annalisa", "initials": "A"}, {"family": "Patera", "given": "Ippolita P", "initials": "IP"}, {"family": "Matteoli", "given": "Maria C", "initials": "MC"}, {"family": "Ciampalini", "given": "Paolo", "initials": "P"}, {"family": "Carducci", "given": "Chiara", "initials": "C"}, {"family": "Lorubbio", "given": "Antonella", "initials": "A"}, {"family": "Schiaffini", "given": "Gabriele", "initials": "G"}, {"family": "Cianfarani", "given": "Stefano", "initials": "S"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Diabetes Res Clin Pract", "issn": "1872-8227", "issn-l": null, "volume": "166", "issue": null, "pages": "108302"}, "abstract": "Management of Type 1 Diabetes (T1D) poses numerous challenges, especially for young children and their families. Parental care positively influencesthe outcomesofchildren with T1D, while there are often criticisms in school environment. The COVID-19 pandemic has forced children and parents to spend many hours at home and diabetes care has returned mainly in the hands of parents.\r\n\r\nTo evaluate the effectiveness of exclusive return to parental care in pre-school and school children with T1D treated with Tandem Basal IQ system during the COVID-19 pandemic.\r\n\r\n22 children (M:F = 14:8) with T1D have been evaluated. We compared insulin and CGM data (TIR, TBR and TAR) of two periods: PRE-COV and IN-COV, in which children have transitioned from normal school attendance to the exclusive care of their parents.\r\n\r\nDuring the IN-COV period a significantly (p < 0.001) higher median value of TIR (66,41%) was observed as compared to PRE-COV period (61,45%). Patients also showed a statistically significant difference (p < 0.002) between the IN-COV period and the PRE-COV period as concerning the TAR metric: respectively 29,86 \u00b1 10,6% vs 34,73 \u00b1 12,8%. The difference between the bolus insulin doses was statistically significant (PRE-COV 5,3 IU/day, IN-COV 7,9 IU/day - p < 0.05).\r\n\r\nOur observational real-life study confirms the positive effect of parental care in T1D very young children and demonstrates that during the COVID-19 pandemic it was possible to obtain a good glycometabolic compensation despite the significant change in lifestyle.", "doi": "10.1016/j.diabres.2020.108302", "pmid": "32623034", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0168-8227(20)30554-4"}, {"db": "pmc", "key": "PMC7332425"}], "notes": [], "created": "2020-12-08T15:04:58.822Z", "modified": "2022-11-10T07:12:20.042Z"}, {"entity": "publication", "iuid": "dafcf340284d46f384c44facaf351f9c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/dafcf340284d46f384c44facaf351f9c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/dafcf340284d46f384c44facaf351f9c"}}, "title": "Perceived Worsening of Tics in Adult Patients with Tourette Syndrome after the COVID-19 Outbreak.", "authors": [{"family": "Mataix-Cols", "given": "David", "initials": "D"}, {"family": "Ringberg", "given": "Helene", "initials": "H"}, {"family": "Fern\u00e1ndez de la Cruz", "given": "Lorena", "initials": "L"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Mov Disord Clin Pract", "issn": "2330-1619", "volume": "7", "issue": "6", "pages": "725-726", "issn-l": null}, "abstract": null, "doi": "10.1002/mdc3.13004", "pmid": "32775530", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "MDC313004"}, {"db": "pmc", "key": "PMC7323109"}], "notes": [], "created": "2020-12-07T13:33:12.659Z", "modified": "2021-02-26T08:45:48.786Z"}, {"entity": "publication", "iuid": "42aaa70ea4114cfc9360097b297d92df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/42aaa70ea4114cfc9360097b297d92df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/42aaa70ea4114cfc9360097b297d92df"}}, "title": "Palliative care: Essential support for patients with heart failure in the COVID-19 pandemic.", "authors": [{"family": "Hill", "given": "Loreena", "initials": "L"}, {"family": "Beattie", "given": "James M", "initials": "JM"}, {"family": "Geller", "given": "Tal Prager", "initials": "TP"}, {"family": "Baruah", "given": "Resham", "initials": "R"}, {"family": "Boyne", "given": "Josiane", "initials": "J"}, {"family": "Stolfo", "given": "Giuseppe Di", "initials": "GD"}, {"family": "Jaarsma", "given": "Tiny", "initials": "T"}], "type": "editorial", "published": "2020-08-00", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "volume": "19", "issue": "6", "pages": "469-472", "issn-l": null}, "abstract": null, "doi": "10.1177/1474515120932814", "pmid": "32515212", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-09T10:31:28.295Z", "modified": "2020-12-09T10:31:28.305Z"}, {"entity": "publication", "iuid": "7011be2092af4e399c629f8276b9f270", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7011be2092af4e399c629f8276b9f270.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7011be2092af4e399c629f8276b9f270"}}, "title": "Optimizing safety surveillance for COVID-19 vaccines.", "authors": [{"family": "Chandler", "given": "Rebecca E", "initials": "RE"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Nat Rev Immunol", "issn": "1474-1741", "volume": "20", "issue": "8", "pages": "451-452", "issn-l": "1474-1733"}, "abstract": null, "doi": "10.1038/s41577-020-0372-8", "pmid": "32555401", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41577-020-0372-8"}, {"db": "pmc", "key": "PMC7298922"}], "notes": [], "created": "2020-11-22T08:40:40.615Z", "modified": "2020-11-30T08:59:20.299Z"}, {"entity": "publication", "iuid": "d5444d00b5ee4c079ee7c5d8184eb62c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5444d00b5ee4c079ee7c5d8184eb62c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5444d00b5ee4c079ee7c5d8184eb62c"}}, "title": "On the interactions of the receptor-binding domain of SARS-CoV-1 and SARS-CoV-2 spike proteins with monoclonal antibodies and the receptor ACE2.", "authors": [{"family": "Corr\u00eaa Giron", "given": "Carolina", "initials": "C"}, {"family": "Laaksonen", "given": "Aatto", "initials": "A"}, {"family": "Barroso da Silva", "given": "Fernando L", "initials": "FL"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Virus Res", "issn": "1872-7492", "volume": "285", "issue": null, "pages": "198021", "issn-l": null}, "abstract": "A new betacoronavirus named SARS-CoV-2 has emerged as a new threat to global health and economy. A promising target for both diagnosis and therapeutics treatments of the new disease named COVID-19 is the coronavirus (CoV) spike (S) glycoprotein. By constant-pH Monte Carlo simulations and the PROCEEDpKa method, we have mapped the electrostatic epitopes for four monoclonal antibodies and the angiotensin-converting enzyme 2 (ACE2) on both SARS-CoV-1 and the new SARS-CoV-2 S receptor binding domain (RBD) proteins. We also calculated free energy of interactions and shown that the S RBD proteins from both SARS viruses binds to ACE2 with similar affinities. However, the affinity between the S RBD protein from the new SARS-CoV-2 and ACE2 is higher than for any studied antibody previously found complexed with SARS-CoV-1. Based on physical chemical analysis and free energies estimates, we can shed some light on the involved molecular recognition processes, their clinical aspects, the implications for drug developments, and suggest structural modifications on the CR3022 antibody that would improve its binding affinities for SARS-CoV-2 and contribute to address the ongoing international health crisis.", "doi": "10.1016/j.virusres.2020.198021", "pmid": "32416259", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Proteins": null}, "xrefs": [{"db": "pii", "key": "S0168-1702(20)30352-X"}, {"db": "pmc", "key": "PMC7228703"}], "notes": [], "created": "2020-12-10T08:53:57.256Z", "modified": "2021-02-26T08:47:18.863Z"}, {"entity": "publication", "iuid": "465be802f0f04f968d6d9ab340e63bb1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/465be802f0f04f968d6d9ab340e63bb1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/465be802f0f04f968d6d9ab340e63bb1"}}, "title": "Management strategies for children with COVID-19: ESPR practical recommendations.", "authors": [{"family": "Raissaki", "given": "Maria", "initials": "M"}, {"family": "Shelmerdine", "given": "Susan C", "initials": "SC"}, {"family": "Damasio", "given": "Maria Beatrice", "initials": "MB"}, {"family": "Toso", "given": "Seema", "initials": "S"}, {"family": "Kvist", "given": "Ola", "initials": "O"}, {"family": "Lovrenski", "given": "Jovan", "initials": "J"}, {"family": "Hirsch", "given": "Franz Wolfgang", "initials": "FW"}, {"family": "G\u00f6rkem", "given": "S\u00fcreyya Burcu", "initials": "SB"}, {"family": "Paterson", "given": "Anne", "initials": "A"}, {"family": "Arthurs", "given": "Owen J", "initials": "OJ"}, {"family": "Rossi", "given": "Andrea", "initials": "A"}, {"family": "van Schuppen", "given": "Joost", "initials": "J"}, {"family": "Petit", "given": "Philippe", "initials": "P"}, {"family": "Argyropoulou", "given": "Maria I", "initials": "MI"}, {"family": "Offiah", "given": "Amaka C", "initials": "AC"}, {"family": "Rosendahl", "given": "Karen", "initials": "K"}, {"family": "Caro-Dom\u00ednguez", "given": "Pablo", "initials": "P"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Pediatr Radiol", "issn": "1432-1998", "issn-l": null, "volume": "50", "issue": "9", "pages": "1313-1323"}, "abstract": "During the outbreak of the COVID-19 pandemic, guidelines have been issued by international, national and local authorities to address management and the need for preparedness. Children with COVID-19 differ from adults in that they are less often and less severely affected. Additional precautions required in the management of children address their increased radiosensitivity, need for accompanying carers, and methods for dealing with children in a mixed adult-paediatric institution. In this guidance document, our aim is to define a pragmatic strategy for imaging children with an emphasis on proven or suspected COVID-19 cases. Children suspected of COVID-19 should not be imaged routinely. Imaging should be performed only when expected to alter patient management, depending on symptoms, preexisting conditions and clinical evolution. In order to prevent disease transmission, it is important to manage the inpatient caseload effectively by triaging children and carers outside the hospital, re-scheduling nonurgent elective procedures and managing symptomatic children and carers as COVID-19 positive until proven otherwise. Within the imaging department one should consider conducting portable examinations with COVID-19 machines or arranging dedicated COVID-19 paediatric imaging sessions and performing routine nasopharyngeal swab testing before imaging under general anaesthesia. Finally, regular personal hygiene, appropriate usage of personal protective equipment, awareness of which procedures are considered aerosol generating and information on how to best disinfect imaging machinery after examinations should be highlighted to all staff members.", "doi": "10.1007/s00247-020-04749-3", "pmid": "32621013", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00247-020-04749-3"}, {"db": "pmc", "key": "PMC7332738"}], "notes": [], "created": "2020-12-08T15:05:31.524Z", "modified": "2020-12-11T12:52:07.380Z"}, {"entity": "publication", "iuid": "d6a624fb7c074de78500a3eff2f91098", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d6a624fb7c074de78500a3eff2f91098.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d6a624fb7c074de78500a3eff2f91098"}}, "title": "Lockdown timing and efficacy in controlling COVID-19 using mobile phone tracking.", "authors": [{"family": "Vinceti", "given": "Marco", "initials": "M"}, {"family": "Filippini", "given": "Tommaso", "initials": "T"}, {"family": "Rothman", "given": "Kenneth J", "initials": "KJ"}, {"family": "Ferrari", "given": "Fabrizio", "initials": "F"}, {"family": "Goffi", "given": "Alessia", "initials": "A"}, {"family": "Maffeis", "given": "Giuseppe", "initials": "G"}, {"family": "Orsini", "given": "Nicola", "initials": "N"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "issn-l": null, "volume": "25", "issue": null, "pages": "100457"}, "abstract": "Italy's severe COVID-19 outbreak was addressed by a lockdown that gradually increased in space, time and intensity. The effectiveness of the lockdown has not been precisely assessed with respect to the intensity of mobility restriction and the time until the outbreak receded.\r\n\r\nWe used processed mobile phone tracking data to measure mobility restriction, and related those data to the number of new SARS-CoV-2 positive cases detected on a daily base in the three most affected Italian regions, Lombardy, Veneto and Emilia-Romagna, from February 1 through April 6, 2020, when two subsequent lockdowns with increasing intensity were implemented by the Italian government.\r\n\r\nDuring the study period, mobility restriction was inversely related to the daily number of newly diagnosed SARS-CoV-2 positive cases only after the second, more effective lockdown, with a peak in the curve of diagnosed cases of infection occurring 14 to 18 days from lockdown in the three regions and 9 to 25 days in the included provinces. An effective reduction in transmission must have occurred nearly immediately after the tighter lockdown, given the lag time of around 10 days from asymptomatic infection to diagnosis. The period from lockdown to peak was shorter in the areas with the highest prevalence of the infection. This effect was seen within slightly more than one week in the most severely affected areas.\r\n\r\nIt appears that the less rigid lockdown led to an insufficient decrease in mobility to reverse an outbreak such as COVID-19. With a tighter lockdown, mobility decreased enough to bring down transmission promptly below the level needed to sustain the epidemic.\r\n\r\nNo funding sources have been used for this work.", "doi": "10.1016/j.eclinm.2020.100457", "pmid": "32838234", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(20)30201-7"}, {"db": "pii", "key": "100457"}, {"db": "pmc", "key": "PMC7355328"}], "notes": [], "created": "2020-12-07T10:32:00.513Z", "modified": "2022-11-10T07:23:24.584Z"}, {"entity": "publication", "iuid": "1ab8d8dc9a0c42f8925aafa2e839129f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1ab8d8dc9a0c42f8925aafa2e839129f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1ab8d8dc9a0c42f8925aafa2e839129f"}}, "title": "Investigation of a COVID-19 outbreak in Germany resulting from a single travel-associated primary case: a case series", "authors": [{"family": "B\u00f6hmer", "given": "Merle M", "initials": "MM"}, {"family": "Buchholz", "given": "Udo", "initials": "U"}, {"family": "Corman", "given": "Victor M", "initials": "VM"}, {"family": "Hoch", "given": "Martin", "initials": "M"}, {"family": "Katz", "given": "Katharina", "initials": "K"}, {"family": "Marosevic", "given": "Durdica V", "initials": "DV"}, {"family": "B\u00f6hm", "given": "Stefanie", "initials": "S"}, {"family": "Woudenberg", "given": "Tom", "initials": "T"}, {"family": "Ackermann", "given": "Nikolaus", "initials": "N"}, {"family": "Konrad", "given": "Regina", "initials": "R"}, {"family": "Eberle", "given": "Ute", "initials": "U"}, {"family": "Treis", "given": "Bianca", "initials": "B"}, {"family": "Dangel", "given": "Alexandra", "initials": "A"}, {"family": "Bengs", "given": "Katja", "initials": "K"}, {"family": "Fingerle", "given": "Volker", "initials": "V"}, {"family": "Berger", "given": "Anja", "initials": "A"}, {"family": "H\u00f6rmansdorfer", "given": "Stefan", "initials": "S"}, {"family": "Ippisch", "given": "Siegfried", "initials": "S"}, {"family": "Wicklein", "given": "Bernd", "initials": "B"}, {"family": "Grahl", "given": "Andreas", "initials": "A"}, {"family": "P\u00f6rtner", "given": "Kirsten", "initials": "K"}, {"family": "Muller", "given": "Nadine", "initials": "N"}, {"family": "Zeitlmann", "given": "Nadine", "initials": "N"}, {"family": "Boender", "given": "T Sonia", "initials": "TS"}, {"family": "Cai", "given": "Wei", "initials": "W"}, {"family": "Reich", "given": "Andreas", "initials": "A"}, {"family": "an der Heiden", "given": "Maria", "initials": "M"}, {"family": "Rexroth", "given": "Ute", "initials": "U"}, {"family": "Hamouda", "given": "Osamah", "initials": "O"}, {"family": "Schneider", "given": "Julia", "initials": "J"}, {"family": "Veith", "given": "Talitha", "initials": "T"}, {"family": "M\u00fchlemann", "given": "Barbara", "initials": "B"}, {"family": "W\u00f6lfel", "given": "Roman", "initials": "R"}, {"family": "Antwerpen", "given": "Markus", "initials": "M"}, {"family": "Walter", "given": "Mathias", "initials": "M"}, {"family": "Protzer", "given": "Ulrike", "initials": "U"}, {"family": "Liebl", "given": "Bernhard", "initials": "B"}, {"family": "Haas", "given": "Walter", "initials": "W"}, {"family": "Sing", "given": "Andreas", "initials": "A"}, {"family": "Drosten", "given": "Christian", "initials": "C"}, {"family": "Zapf", "given": "Andreas", "initials": "A"}], "type": "journal-article", "published": "2020-08-00", "journal": {"title": "The Lancet Infectious Diseases", "issn": "1473-3099", "volume": "20", "issue": "8", "pages": "920-928", "issn-l": null}, "abstract": "In December, 2019, the newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, causing COVID-19, a respiratory disease presenting with fever, cough, and often pneumonia. WHO has set the strategic objective to interrupt spread of SARS-CoV-2 worldwide. An outbreak in Bavaria, Germany, starting at the end of January, 2020, provided the opportunity to study transmission events, incubation period, and secondary attack rates.\n\nA case was defined as a person with SARS-CoV-2 infection confirmed by RT-PCR. Case interviews were done to describe timing of onset and nature of symptoms and to identify and classify contacts as high risk (had cumulative face-to-face contact with a confirmed case for \u226515 min, direct contact with secretions or body fluids of a patient with confirmed COVID-19, or, in the case of health-care workers, had worked within 2 m of a patient with confirmed COVID-19 without personal protective equipment) or low risk (all other contacts). High-risk contacts were ordered to stay at home in quarantine for 14 days and were actively followed up and monitored for symptoms, and low-risk contacts were tested upon self-reporting of symptoms. We defined fever and cough as specific symptoms, and defined a prodromal phase as the presence of non-specific symptoms for at least 1 day before the onset of specific symptoms. Whole genome sequencing was used to confirm epidemiological links and clarify transmission events where contact histories were ambiguous; integration with epidemiological data enabled precise reconstruction of exposure events and incubation periods. Secondary attack rates were calculated as the number of cases divided by the number of contacts, using Fisher's exact test for the 95% CIs.\n\nPatient 0 was a Chinese resident who visited Germany for professional reasons. 16 subsequent cases, often with mild and non-specific symptoms, emerged in four transmission generations. Signature mutations in the viral genome occurred upon foundation of generation 2, as well as in one case pertaining to generation 4. The median incubation period was 4\u00b70 days (IQR 2\u00b73-4\u00b73) and the median serial interval was 4\u00b70 days (3\u00b70-5\u00b70). Transmission events were likely to have occurred presymptomatically for one case (possibly five more), at the day of symptom onset for four cases (possibly five more), and the remainder after the day of symptom onset or unknown. One or two cases resulted from contact with a case during the prodromal phase. Secondary attack rates were 75\u00b70% (95% CI 19\u00b70-99\u00b70; three of four people) among members of a household cluster in common isolation, 10\u00b70% (1\u00b72-32\u00b70; two of 20) among household contacts only together until isolation of the patient, and 5\u00b71% (2\u00b76-8\u00b79; 11 of 217) among non-household, high-risk contacts.\n\nAlthough patients in our study presented with predominately mild, non-specific symptoms, infectiousness before or on the day of symptom onset was substantial. Additionally, the incubation period was often very short and false-negative tests occurred. These results suggest that although the outbreak was controlled, successful long-term and global containment of COVID-19 could be difficult to achieve.\n\nAll authors are employed and all expenses covered by governmental, federal state, or other publicly funded institutions.", "doi": "10.1016/s1473-3099(20)30314-5", "pmid": "32422201", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7228725"}, {"db": "pii", "key": "S1473-3099(20)30314-5"}], "notes": [], "created": "2020-12-10T08:57:10.569Z", "modified": "2023-06-19T15:24:24.557Z"}, {"entity": "publication", "iuid": "af81d5d1037f49c09189c3c0c55d609e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/af81d5d1037f49c09189c3c0c55d609e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/af81d5d1037f49c09189c3c0c55d609e"}}, "title": "Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity.", "authors": [{"family": "Guallar", "given": "Mar\u00eda Pilar", "initials": "MP"}, {"family": "Meiri\u00f1o", "given": "Rosa", "initials": "R"}, {"family": "Donat-Vargas", "given": "Carolina", "initials": "C"}, {"family": "Corral", "given": "Octavio", "initials": "O"}, {"family": "Jouv\u00e9", "given": "Nicol\u00e1s", "initials": "N"}, {"family": "Soriano", "given": "Vicente", "initials": "V"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": "97", "issue": null, "pages": "290-292"}, "abstract": "A relationship between the infecting dose and the risk of disease severity has not been demonstrated for SARS-CoV-2 infection. Here, we report three clusters of individuals that were potentially exposed to distinct inoculum in Madrid. Overall each group developed divergent clinical forms of COVID-19. Our data support that a greater viral inoculum at the time of SARS-CoV-2 exposure might determine a higher risk of severe COVID-19.", "doi": "10.1016/j.ijid.2020.06.035", "pmid": "32553720", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(20)30470-7"}, {"db": "pmc", "key": "PMC7293836"}], "notes": [], "created": "2020-12-09T07:48:44.715Z", "modified": "2021-02-26T08:45:48.582Z"}, {"entity": "publication", "iuid": "c1cd8bba32f3469cbe65a77299dc9595", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1cd8bba32f3469cbe65a77299dc9595.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1cd8bba32f3469cbe65a77299dc9595"}}, "title": "Inhalational volatile-based sedation for COVID-19 pneumonia and ARDS.", "authors": [{"family": "Jerath", "given": "Angela", "initials": "A"}, {"family": "Ferguson", "given": "Niall D", "initials": "ND"}, {"family": "Cuthbertson", "given": "Brian", "initials": "B"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Intensive Care Med", "issn": "1432-1238", "volume": "46", "issue": "8", "pages": "1563-1566", "issn-l": "0342-4642"}, "abstract": "Hospitals worldwide are experiencing a shortage in essential intravenous sedative medications. This is attributable to high number and high sedative needs of COVID-19 critical care patients with disruption of drug supply chains. Inhaled volatile anesthetic agents are an abundant resource and readily implementable solution for providing ICU sedation. Inhaled volatile agents may also provide important pulmonary benefits for COVID-19 patients with ARDS that could improve gas exchange and reduce time spent on a ventilator. We review the use of volatile agents, and provide a technical overview and algorithm for administering inhaled volatile-based sedation in ICUs.", "doi": "10.1007/s00134-020-06154-8", "pmid": "32588067", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00134-020-06154-8"}, {"db": "pmc", "key": "PMC7315695"}], "notes": [], "created": "2020-12-08T15:48:14.991Z", "modified": "2020-12-08T15:48:15.004Z"}, {"entity": "publication", "iuid": "9cf51abd932249898af01c24bd5289e3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9cf51abd932249898af01c24bd5289e3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9cf51abd932249898af01c24bd5289e3"}}, "title": "Impact of the COVID-19 pandemic on ongoing cardiovascular research projects: considerations and adaptations.", "authors": [{"family": "Van Bulck", "given": "Liesbet", "initials": "L"}, {"family": "Kovacs", "given": "Adrienne H", "initials": "AH"}, {"family": "Goossens", "given": "Eva", "initials": "E"}, {"family": "Luyckx", "given": "Koen", "initials": "K"}, {"family": "Jaarsma", "given": "Tiny", "initials": "T"}, {"family": "Str\u00f6mberg", "given": "Anna", "initials": "A"}, {"family": "Moons", "given": "Philip", "initials": "P"}], "type": "editorial", "published": "2020-08-00", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "volume": "19", "issue": "6", "pages": "465-468", "issn-l": null}, "abstract": null, "doi": "10.1177/1474515120926629", "pmid": "32418455", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-10T08:56:28.283Z", "modified": "2020-12-10T08:56:28.296Z"}, {"entity": "publication", "iuid": "137eb41ee24d46898ba5785cebd6f1df", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/137eb41ee24d46898ba5785cebd6f1df.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/137eb41ee24d46898ba5785cebd6f1df"}}, "title": "Hyperreninemia and low total body water may contribute to acute kidney injury in COVID-19 patients in intensive care.", "authors": [{"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M"}, {"family": "von Seth", "given": "Magnus", "initials": "M"}, {"family": "Frithiof", "given": "Robert", "initials": "R"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "J Hypertens", "issn": "1473-5598", "issn-l": "0263-6352", "volume": "38", "issue": "8", "pages": "1613-1614"}, "abstract": "No abstract available", "doi": "10.1097/HJH.0000000000002531", "pmid": "32472780", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "NA", "key": "Provided in the article: biochemistry of patients in intensive care (N=9)", "description": null}], "notes": [], "created": "2020-10-30T11:42:00.648Z", "modified": "2021-02-26T08:45:02.849Z"}, {"entity": "publication", "iuid": "666b3cf7632f4444bc8e1b4aab6b02b4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/666b3cf7632f4444bc8e1b4aab6b02b4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/666b3cf7632f4444bc8e1b4aab6b02b4"}}, "title": "Global Survey on Pancreatic Surgery During the COVID-19 Pandemic.", "authors": [{"family": "Oba", "given": "Atsushi", "initials": "A"}, {"family": "Stoop", "given": "Thomas F", "initials": "TF"}, {"family": "L\u00f6hr", "given": "Matthias", "initials": "M"}, {"family": "Hackert", "given": "Thilo", "initials": "T"}, {"family": "Zyromski", "given": "Nicholas", "initials": "N"}, {"family": "Nealon", "given": "William H", "initials": "WH"}, {"family": "Unno", "given": "Michiaki", "initials": "M"}, {"family": "Schulick", "given": "Richard D", "initials": "RD"}, {"family": "Al-Musawi", "given": "Mohammed H", "initials": "MH"}, {"family": "Wu", "given": "Wenming", "initials": "W"}, {"family": "Zhao", "given": "Yupei", "initials": "Y"}, {"family": "Satoi", "given": "Sohei", "initials": "S"}, {"family": "Wolfgang", "given": "Christopher L", "initials": "CL"}, {"family": "Abu Hilal", "given": "Mohammad", "initials": "M"}, {"family": "Besselink", "given": "Marc G", "initials": "MG"}, {"family": "Del Chiaro", "given": "Marco", "initials": "M"}, {"family": "Pancreas Club, European Pancreatic Club, Chinese Pancreatic Surgery Association, European Consortium on Minimally Invasive Pancreatic Surgery, Study Group of Preoperative Therapy for Pancreatic Cancer, Study Group of Pancreatic Ductal Adenocarcinoma with Peritoneal Metastasis and International Study Group on Cystic Tumors of the Pancreas", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Ann Surg", "issn": "1528-1140", "volume": "272", "issue": "2", "pages": "e87-e93", "issn-l": null}, "abstract": "The aim of this study was to clarify the role of pancreatic surgery during the COVID-19 pandemic to optimize patients' and clinicians' safety and safeguard health care capacity.\n\nThe COVID-19 pandemic heavily impacts health care systems worldwide. Cancer patients appear to have an increased risk for adverse events when infected by COVID-19, but the inability to receive oncological care seems may be an even larger threat, particularly in case of pancreatic cancer.\n\nAn online survey was submitted to all members of seven international pancreatic associations and study groups, investigating the impact of the COVID-19 pandemic on pancreatic surgery using 21 statements (April, 2020). Consensus was defined as >80% agreement among respondents and moderate agreement as 60% to 80% agreement.\n\nA total of 337 respondents from 267 centers and 37 countries spanning 5 continents completed the survey. Most respondents were surgeons (n = 302, 89.6%) and working in an academic center (n = 286, 84.9%). The majority of centers (n = 166, 62.2%) performed less pancreatic surgery because of the COVID-19 pandemic, reducing the weekly pancreatic resection rate from 3 [interquartile range (IQR) 2-5] to 1 (IQR 0-2) (P < 0.001). Most centers screened for COVID-19 before pancreatic surgery (n = 233, 87.3%). Consensus was reached on 13 statements and 5 statements achieved moderate agreement.\n\nThis global survey elucidates the role of pancreatic surgery during the COVID-19 pandemic, regarding patient selection for the surgical and oncological treatment of pancreatic diseases to support clinical decision-making and creating a starting point for further discussion.", "doi": "10.1097/SLA.0000000000004006", "pmid": "32675507", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "00000658-202008000-00027"}, {"db": "pmc", "key": "PMC7268883"}], "notes": [], "created": "2020-12-07T16:35:13.417Z", "modified": "2021-02-26T08:45:48.271Z"}, {"entity": "publication", "iuid": "19e27f15f057496f97f18f9b6d599e2e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19e27f15f057496f97f18f9b6d599e2e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19e27f15f057496f97f18f9b6d599e2e"}}, "title": "Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020.", "authors": [{"family": "Alm", "given": "Erik", "initials": "E"}, {"family": "Broberg", "given": "Eeva K", "initials": "EK"}, {"family": "Connor", "given": "Thomas", "initials": "T"}, {"family": "Hodcroft", "given": "Emma B", "initials": "EB"}, {"family": "Komissarov", "given": "Andrey B", "initials": "AB"}, {"family": "Maurer-Stroh", "given": "Sebastian", "initials": "S"}, {"family": "Melidou", "given": "Angeliki", "initials": "A"}, {"family": "Neher", "given": "Richard A", "initials": "RA"}, {"family": "O'Toole", "given": "\u00c1ine", "initials": "\u00c1"}, {"family": "Pereyaslov", "given": "Dmitriy", "initials": "D"}, {"family": "WHO European Region sequencing laboratories and GISAID EpiCoV group", "given": "", "initials": ""}, {"family": "WHO European Region sequencing laboratories and GISAID EpiCoV group*", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "32", "issn-l": null}, "abstract": "We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation, compare the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2.", "doi": "10.2807/1560-7917.ES.2020.25.32.2001410", "pmid": "32794443", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7427299"}], "notes": [], "created": "2020-12-07T13:23:05.531Z", "modified": "2021-02-26T08:46:12.957Z"}, {"entity": "publication", "iuid": "23cc455881f449c0a93ce9cff278ca53", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/23cc455881f449c0a93ce9cff278ca53.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/23cc455881f449c0a93ce9cff278ca53"}}, "title": "Flexibility and safety in times of coronavirus disease 2019 (COVID-19): Implications for nurses and allied professionals in cardiology.", "authors": [{"family": "Jaarsma", "given": "Tiny", "initials": "T"}, {"family": "van der Wal", "given": "Martje", "initials": "M"}, {"family": "Hinterbuchner", "given": "Lynne", "initials": "L"}, {"family": "K\u00f6berich", "given": "Stefan", "initials": "S"}, {"family": "Lie", "given": "Irene", "initials": "I"}, {"family": "Str\u00f6mberg", "given": "Anna", "initials": "A"}], "type": "editorial", "published": "2020-08-00", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "volume": "19", "issue": "6", "pages": "462-464", "issn-l": null}, "abstract": null, "doi": "10.1177/1474515120921027", "pmid": "32323572", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7441330"}], "notes": [], "created": "2020-12-09T14:53:50.944Z", "modified": "2020-12-09T14:53:50.954Z"}, {"entity": "publication", "iuid": "80bed42b5a9b45b296b0ca6afd771097", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/80bed42b5a9b45b296b0ca6afd771097.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/80bed42b5a9b45b296b0ca6afd771097"}}, "title": "Exercise in the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) era: A Question and Answer session with the experts Endorsed by the section of Sports Cardiology & Exercise of the European Association of Preventive Cardiology (EAPC).", "authors": [{"family": "Bhatia", "given": "Raghav T", "initials": "RT"}, {"family": "Marwaha", "given": "Sarandeep", "initials": "S"}, {"family": "Malhotra", "given": "Aneil", "initials": "A"}, {"family": "Iqbal", "given": "Zafar", "initials": "Z"}, {"family": "Hughes", "given": "Christopher", "initials": "C"}, {"family": "B\u00f6rjesson", "given": "Mats", "initials": "M"}, {"family": "Niebauer", "given": "Josef", "initials": "J"}, {"family": "Pelliccia", "given": "Antonio", "initials": "A"}, {"family": "Schmied", "given": "Christian", "initials": "C"}, {"family": "Serratosa", "given": "Luis", "initials": "L"}, {"family": "Papadakis", "given": "Michael", "initials": "M"}, {"family": "Sharma", "given": "Sanjay", "initials": "S"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Eur J Prev Cardiol", "issn": "2047-4881", "volume": "27", "issue": "12", "pages": "1242-1251", "issn-l": null}, "abstract": "Regular exercise has multiple benefits for physical and mental health, including the body's ability to combat infections. The current COVID-19 pandemic and the social distancing measures employed to curtail the impact of the infection are likely to reduce the amount of usual physical activity being performed by most individuals, including habitual exercisers. The uncertainties relating to the impact of the SARS-CoV-2 virus on the heart may cause increased anxiety, particularly in athletes who need to sustain a vigorous exercise regime in order to maintain their skills and fitness in preparation for return to competition after a short re-training period. The aim of this document is to provide practical answers to pertinent questions being posed by the sporting community, in an attempt to offer reassurance, promote safe participation in exercise during as well as after the COVID-19 pandemic and provide a framework of management for physicians caring for athletes.", "doi": "10.1177/2047487320930596", "pmid": "32475157", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-09T10:58:22.606Z", "modified": "2020-12-09T10:58:22.628Z"}, {"entity": "publication", "iuid": "336a049f34ae4df0a98f6b91d351915c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/336a049f34ae4df0a98f6b91d351915c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/336a049f34ae4df0a98f6b91d351915c"}}, "title": "European Task Force on Contact Dermatitis statement on coronavirus disease-19 (COVID-19) outbreak and the risk of adverse cutaneous reactions.", "authors": [{"family": "Balato", "given": "A", "initials": "A"}, {"family": "Ayala", "given": "F", "initials": "F"}, {"family": "Bruze", "given": "M", "initials": "M"}, {"family": "Crepy", "given": "M-N", "initials": "MN"}, {"family": "Gon\u00e7alo", "given": "M", "initials": "M"}, {"family": "Johansen", "given": "J", "initials": "J"}, {"family": "John", "given": "S M", "initials": "SM"}, {"family": "Pigatto", "given": "P", "initials": "P"}, {"family": "Raimondo", "given": "A", "initials": "A"}, {"family": "Rustemeyer", "given": "T", "initials": "T"}, {"family": "Schuttelaar", "given": "M-L A", "initials": "MA"}, {"family": "Svedman", "given": "C", "initials": "C"}, {"family": "Aerts", "given": "O", "initials": "O"}, {"family": "Uter", "given": "W", "initials": "W"}, {"family": "Wilkinson", "given": "M", "initials": "M"}, {"family": "Gimenez-Arnau", "given": "A", "initials": "A"}], "type": "letter", "published": "2020-08-00", "journal": {"title": "J Eur Acad Dermatol Venereol", "issn": "1468-3083", "volume": "34", "issue": "8", "pages": "e353-e354", "issn-l": null}, "abstract": null, "doi": "10.1111/jdv.16557", "pmid": "32356382", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-10T07:17:53.057Z", "modified": "2020-12-10T07:17:53.068Z"}, {"entity": "publication", "iuid": "e3aae2291569457e80d5f36dff065efc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3aae2291569457e80d5f36dff065efc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3aae2291569457e80d5f36dff065efc"}}, "title": "Estimation of the COVID-19 burden in Egypt through exported case detection.", "authors": [{"family": "Tuite", "given": "Ashleigh R", "initials": "AR"}, {"family": "Ng", "given": "Victoria", "initials": "V"}, {"family": "Rees", "given": "Erin", "initials": "E"}, {"family": "Fisman", "given": "David", "initials": "D"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Khan", "given": "Kamran", "initials": "K"}, {"family": "Bogoch", "given": "Isaac I", "initials": "II"}], "type": "letter", "published": "2020-08-00", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "volume": "20", "issue": "8", "pages": "894", "issn-l": null}, "abstract": null, "doi": "10.1016/S1473-3099(20)30233-4", "pmid": "32222162", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(20)30233-4"}, {"db": "pmc", "key": "PMC7195316"}], "notes": [], "created": "2020-12-10T08:58:07.204Z", "modified": "2020-12-10T08:58:07.215Z"}, {"entity": "publication", "iuid": "41aacb23f79843de9c9fd92f17eadda4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/41aacb23f79843de9c9fd92f17eadda4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/41aacb23f79843de9c9fd92f17eadda4"}}, "title": "Estimation of COVID-19 burden in Egypt - Authors' reply.", "authors": [{"family": "Tuite", "given": "Ashleigh R", "initials": "AR"}, {"family": "Ng", "given": "Victoria", "initials": "V"}, {"family": "Rees", "given": "Erin", "initials": "E"}, {"family": "Fisman", "given": "David", "initials": "D"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Khan", "given": "Kamran", "initials": "K"}, {"family": "Bogoch", "given": "Isaac I", "initials": "II"}], "type": "letter", "published": "2020-08-00", "journal": {"title": "Lancet Infect Dis", "issn": "1474-4457", "volume": "20", "issue": "8", "pages": "897-898", "issn-l": null}, "abstract": null, "doi": "10.1016/S1473-3099(20)30326-1", "pmid": "32353344", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1473-3099(20)30326-1"}, {"db": "pmc", "key": "PMC7185943"}], "notes": [], "created": "2020-12-10T07:16:28.263Z", "modified": "2020-12-10T07:16:28.272Z"}, {"entity": "publication", "iuid": "8b7103dffee443d1b2b330f2beec8184", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b7103dffee443d1b2b330f2beec8184.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b7103dffee443d1b2b330f2beec8184"}}, "title": "Delivery of hepato-pancreato-biliary surgery during the COVID-19 pandemic: an European-African Hepato-Pancreato-Biliary Association (E-AHPBA) cross-sectional survey.", "authors": [{"family": "Balakrishnan", "given": "Anita", "initials": "A"}, {"family": "Lesurtel", "given": "Mickael", "initials": "M"}, {"family": "Siriwardena", "given": "Ajith K", "initials": "AK"}, {"family": "Heinrich", "given": "Stefan", "initials": "S"}, {"family": "Serrablo", "given": "Alejandro", "initials": "A"}, {"family": "Besselink", "given": "Marc G H", "initials": "MGH"}, {"family": "Erkan", "given": "Mert", "initials": "M"}, {"family": "Andersson", "given": "Bodil", "initials": "B"}, {"family": "Polak", "given": "Wojciech G", "initials": "WG"}, {"family": "Laurenzi", "given": "Andrea", "initials": "A"}, {"family": "Olde Damink", "given": "Stefan W M", "initials": "SWM"}, {"family": "Berrevoet", "given": "Frederik", "initials": "F"}, {"family": "Frigerio", "given": "Isabella", "initials": "I"}, {"family": "Ramia", "given": "Jose M", "initials": "JM"}, {"family": "Gallagher", "given": "Thomas K", "initials": "TK"}, {"family": "Warner", "given": "Susanne", "initials": "S"}, {"family": "Shrikhande", "given": "Shailesh V", "initials": "SV"}, {"family": "Adam", "given": "Rene", "initials": "R"}, {"family": "Smith", "given": "Martin D", "initials": "MD"}, {"family": "Conlon", "given": "Kevin C", "initials": "KC"}, {"family": "E-AHPBA Scientific and Research Committee", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "HPB (Oxford)", "issn": "1477-2574", "volume": "22", "issue": "8", "pages": "1128-1134", "issn-l": null}, "abstract": "The extent of the COVID-19 pandemic and the resulting response has varied globally. The European and African Hepato-Pancreato-Biliary Association (E-AHPBA), the premier representative body for practicing HPB surgeons in Europe and Africa, conducted this survey to assess the impact of COVID-19 on HPB surgery.\n\nAn online survey was disseminated to all E-AHPBA members to assess the effects of the pandemic on unit capacity, management of HPB cancers, use of COVID-19 screening and other aspects of service delivery.\n\nOverall, 145 (25%) members responded. Most units, particularly in COVID-high countries (>100,000 cases) reported insufficient critical care capacity and reduced HPB operating sessions compared to COVID-low countries. Delayed access to cancer surgery necessitated alternatives including increased neoadjuvant chemotherapy for pancreatic cancer and colorectal liver metastases, and locoregional treatments for hepatocellular carcinoma. Other aspects of service delivery including COVID-19 screening and personal protective equipment varied between units and countries.\n\nThis study demonstrates that the COVID-19 pandemic has had a profound adverse impact on the delivery of HPB cancer care across the continents of Europe and Africa. The findings illustrate the need for safe resumption of cancer surgery in a \"new\" normal world with screening of patients and staff for COVID-19.", "doi": "10.1016/j.hpb.2020.05.012", "pmid": "32565039", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S1365-182X(20)31040-6"}, {"db": "pmc", "key": "PMC7284265"}], "notes": [], "created": "2020-12-08T16:33:29.400Z", "modified": "2021-02-26T08:46:13.366Z"}, {"entity": "publication", "iuid": "311ba3cc55dd4405af16b70d0fa700b7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/311ba3cc55dd4405af16b70d0fa700b7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/311ba3cc55dd4405af16b70d0fa700b7"}}, "title": "Delivering healthcare remotely to cardiovascular patients during COVID-19 : A rapid review of the evidence.", "authors": [{"family": "Neubeck", "given": "Lis", "initials": "L"}, {"family": "Hansen", "given": "Tina", "initials": "T"}, {"family": "Jaarsma", "given": "Tiny", "initials": "T"}, {"family": "Klompstra", "given": "Leonie", "initials": "L"}, {"family": "Gallagher", "given": "Robyn", "initials": "R"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Eur J Cardiovasc Nurs", "issn": "1873-1953", "volume": "19", "issue": "6", "pages": "486-494", "issn-l": null}, "abstract": "Although attention is focused on addressing the acute situation created by the COVID-19 illness, it is imperative to continue our efforts to prevent cardiovascular morbidity and mortality, particularly during a period of prolonged social isolation which may limit physical activity, adversely affect mental health and reduce access to usual care. One option may be to deliver healthcare interventions remotely through digital healthcare solutions. Therefore, the aim of this paper is to bring together the evidence for remote healthcare during a quarantine situation period to support people living with cardiovascular disease during COVID-19 isolation.\n\nThe PubMed, CINAHL and Google Scholar were searched using telehealth OR digital health OR mHealth OR eHealth OR mobile apps AND COVID-19 OR quarantine search terms. We also searched for literature relating to cardiovascular disease AND quarantine.\n\nThe literature search identified 45 potentially relevant publications, out of which nine articles were included. Three overarching themes emerged from this review: (1) preparing the workforce and ensuring reimbursement for remote healthcare, (2) supporting mental and physical health and (3) supporting usual care.\n\nTo support people living with cardiovascular disease during COVID-19 isolation and to mitigate the effects of quarantine and adverse effect on mental and physical well-being, we should offer remote healthcare and provide access to their usual care.", "doi": "10.1177/1474515120924530", "pmid": "32380858", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-30T09:10:05.652Z", "modified": "2020-11-30T09:10:05.676Z"}, {"entity": "publication", "iuid": "9d81995f5daf410da34016e079e9bd0a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9d81995f5daf410da34016e079e9bd0a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9d81995f5daf410da34016e079e9bd0a"}}, "title": "Dealing with sleep problems during home confinement due to the COVID-19 outbreak: Practical recommendations from a task force of the European CBT-I Academy.", "authors": [{"family": "Altena", "given": "Ellemarije", "initials": "E"}, {"family": "Baglioni", "given": "Chiara", "initials": "C"}, {"family": "Espie", "given": "Colin A", "initials": "CA"}, {"family": "Ellis", "given": "Jason", "initials": "J"}, {"family": "Gavriloff", "given": "Dimitri", "initials": "D"}, {"family": "Holzinger", "given": "Brigitte", "initials": "B"}, {"family": "Schlarb", "given": "Angelika", "initials": "A"}, {"family": "Frase", "given": "Lukas", "initials": "L"}, {"family": "Jernel\u00f6v", "given": "Susanna", "initials": "S"}, {"family": "Riemann", "given": "Dieter", "initials": "D"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "J Sleep Res", "issn": "1365-2869", "volume": "29", "issue": "4", "pages": "e13052", "issn-l": "0962-1105"}, "abstract": "Editorial\r\n\r\nIn the current global home confinement situation due to the COVID-19 outbreak, most individuals are exposed to an unprecedented stressful situation of unknown duration. This may not only increase daytime stress, anxiety and depression levels, but also disrupt sleep. Importantly, because of the fundamental role that sleep plays in emotion regulation, sleep disturbance can have direct consequences upon next day emotional functioning. In this paper, we summarize what is known about the stress-sleep link and confinement as well as effective insomnia treatment. We discuss those effects of the current home confinement situation that can disrupt sleep but also those that could benefit sleep quality. We suggest adaptions of cognitive behavioural therapy elements that are feasible to implement for those facing changed work schedules and requirements, those with health anxiety and those handling childcare and home-schooling, whilst also recognizing the general limitations imposed on physical exercise and social interaction. Managing sleep problems as best as possible during home confinement can limit stress and possibly prevent disruptions of social relationships.", "doi": "10.1111/jsr.13052", "pmid": "32246787", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-25T07:26:15.028Z", "modified": "2020-11-30T15:56:39.059Z"}, {"entity": "publication", "iuid": "2ab907e81c514e46a3d203d801cff0ad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ab907e81c514e46a3d203d801cff0ad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ab907e81c514e46a3d203d801cff0ad"}}, "title": "D-dimer in patients infected with COVID-19 and suspected pulmonary embolism.", "authors": [{"family": "Garcia-Oliv\u00e9", "given": "Ignasi", "initials": "I"}, {"family": "Sintes", "given": "Helena", "initials": "H"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Abad Capa", "given": "Jorge", "initials": "J"}, {"family": "Rosell", "given": "Antoni", "initials": "A"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Respir Med", "issn": "1532-3064", "volume": "169", "issue": null, "pages": "106023", "issn-l": "0954-6111"}, "abstract": "To analyze the risk factors for pulmonary embolism (PE) in patients infected with COVID-19.\n\nWe conducted an observational, retrospective study. Patients with severe infection with COVID-19 and suspected PE were included.\n\nPatients with higher levels of D-dimer and those requiring intubation were at a higher risk of developing PE. Higher D-dimer levels were associated with a greater probability of PE 3, 6, 9 and 12 days after determining D-dimer levels with an OR of 1.7, 2.0, 2.4 and 2.4, respectively.\n\nIn conclusion, patients infected with COVID-19 requiring OTI with higher levels of D-dimer have an increased risk of developing PE.", "doi": "10.1016/j.rmed.2020.106023", "pmid": "32454268", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "S0954-6111(20)30163-3"}, {"db": "pmc", "key": "PMC7219417"}], "notes": [], "created": "2020-11-25T09:15:41.624Z", "modified": "2021-02-26T08:45:02.911Z"}, {"entity": "publication", "iuid": "fc7182e6cfb14b3687e06c6a096d218f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc7182e6cfb14b3687e06c6a096d218f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc7182e6cfb14b3687e06c6a096d218f"}}, "title": "Children are unlikely to be the main drivers of the COVID-19 pandemic - A systematic review.", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "volume": "109", "issue": "8", "pages": "1525-1530", "issn-l": null}, "abstract": "Many countries have closed schools and kindergartens to minimise COVID-19, but the role that children play in disease transmission is unclear.\r\n\r\nA systematic literature review of the MEDLINE and EMBASE databases and medRxiv/bioRxiv preprint servers to 11 May 2020 identified published and unpublished papers on COVID-19 transmission by children.\r\n\r\nWe identified 700 scientific papers and letters and 47 full texts were studied in detail. Children accounted for a small fraction of COVID-19 cases and mostly had social contacts with peers or parents, rather than older people at risk of severe disease. Data on viral loads were scarce, but indicated that children may have lower levels than adults, partly because they often have fewer symptoms, and this should decrease the transmission risk. Household transmission studies showed that children were rarely the index case and case studies suggested that children with COVID-19 seldom caused outbreaks. However, it is highly likely that children can transmit the SARS-COV-2 virus, which causes COVID-19, and even asymptomatic children can have viral loads.\r\n\r\nChildren are unlikely to be the main drivers of the pandemic. Opening up schools and kindergartens is unlikely to impact COVID-19 mortality rates in older people.", "doi": "10.1111/apa.15371", "pmid": "32430964", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-04T15:37:40.145Z", "modified": "2020-11-26T12:12:34.222Z"}, {"entity": "publication", "iuid": "4516da93170f4a63955ab4a4014f3836", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4516da93170f4a63955ab4a4014f3836.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4516da93170f4a63955ab4a4014f3836"}}, "title": "COVID-19 and neurointerventional service worldwide: a survey of the European Society of Minimally Invasive Neurological Therapy (ESMINT), the Society of NeuroInterventional Surgery (SNIS), the Sociedad Iberolatinoamericana de Neuroradiologia Diagnostica y Terapeutica (SILAN), the Society of Vascular and Interventional Neurology (SVIN), and the World Federation of Interventional and Therapeutic Neuroradiology (WFITN).", "authors": [{"family": "Fiehler", "given": "Jens", "initials": "J"}, {"family": "Brouwer", "given": "Patrick", "initials": "P"}, {"family": "D\u00edaz", "given": "Carlos", "initials": "C"}, {"family": "Hirsch", "given": "Joshua A", "initials": "JA"}, {"family": "Kulcsar", "given": "Zsolt", "initials": "Z"}, {"family": "Liebeskind", "given": "David", "initials": "D"}, {"family": "Linfante", "given": "Italo", "initials": "I"}, {"family": "Lylyk", "given": "Pedro", "initials": "P"}, {"family": "Mack", "given": "William J", "initials": "WJ"}, {"family": "Milburn", "given": "James", "initials": "J"}, {"family": "Nogueira", "given": "Raul", "initials": "R"}, {"family": "Orbach", "given": "Darren B", "initials": "DB"}, {"family": "Pumar", "given": "Jos\u00e9 Manuel Manuel", "initials": "JMM"}, {"family": "Tanaka", "given": "Michihiro", "initials": "M"}, {"family": "Taylor", "given": "Allan", "initials": "A"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "J Neurointerv Surg", "issn": "1759-8486", "volume": "12", "issue": "8", "pages": "726-730", "issn-l": "1759-8478"}, "abstract": "This survey was focused on the provision of neurointerventional services, the current practices of managing patients under COVID-19 conditions, and the expectations for the future.\n\nInvitations for this survey were sent out as a collaborative effort of the European Society of Minimally Invasive Neurological Therapy (ESMINT), the Society of NeuroInterventional Surgery (SNIS), the Sociedad Iberolatinoamericana de Neuroradiologia Diagnostica y Terapeutica (SILAN), the Society of Vascular and Interventional Neurology (SVIN), and the World Federation of Interventional and Therapeutic Neuroradiology (WFITN).\n\nOverall, 475 participants from 61 countries responded (six from Africa (1%), 81 from Asia (17%), 156 from Europe (33%), 53 from Latin America (11%), and 172 from North America (11%)). The majority of participants (96%) reported being able to provide emergency services, though 26% of these reported limited resources. A decrease in emergency procedures was reported by 69% of participants (52% in ischemic and hemorrhagic stroke, 11% ischemic, and 6% hemorrhagic stroke alone). Only 4% reported an increase in emergency cases. The emerging need for social distancing and the rapid adoption of remote communication was reflected in the interest in establishing case discussion forums (43%), general online forums (37%), and access to angio video streaming for live mentoring and support (33%).\n\nNeurointerventional emergency services are available in almost all centers, while the number of emergency patients is markedly decreased. Half of the participants have abandoned neurointerventions in non-emergent situations. There are considerable variations in the management of neurointerventions and in the expectations for the future.", "doi": "10.1136/neurintsurg-2020-016349", "pmid": "32546635", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "neurintsurg-2020-016349"}, {"db": "pmc", "key": "PMC7316120"}], "notes": [], "created": "2020-12-09T07:51:50.699Z", "modified": "2021-02-26T08:45:02.973Z"}, {"entity": "publication", "iuid": "a7cea9e2b86b45dc86bb5fd882d4aff0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a7cea9e2b86b45dc86bb5fd882d4aff0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a7cea9e2b86b45dc86bb5fd882d4aff0"}}, "title": "Building an international consortium for tracking coronavirus health status.", "authors": [{"family": "Segal", "given": "Eran", "initials": "E"}, {"family": "Zhang", "given": "Feng", "initials": "F"}, {"family": "Lin", "given": "Xihong", "initials": "X"}, {"family": "King", "given": "Gary", "initials": "G"}, {"family": "Shalem", "given": "Ophir", "initials": "O"}, {"family": "Shilo", "given": "Smadar", "initials": "S"}, {"family": "Allen", "given": "William E", "initials": "WE"}, {"family": "Alquaddoomi", "given": "Faisal", "initials": "F"}, {"family": "Altae-Tran", "given": "Han", "initials": "H"}, {"family": "Anders", "given": "Simon", "initials": "S"}, {"family": "Balicer", "given": "Ran", "initials": "R"}, {"family": "Bauman", "given": "Tal", "initials": "T"}, {"family": "Bonilla", "given": "Ximena", "initials": "X"}, {"family": "Booman", "given": "Gisel", "initials": "G"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "Cohen", "given": "Ori", "initials": "O"}, {"family": "Coletti", "given": "Silvano", "initials": "S"}, {"family": "Davidson", "given": "Natalie", "initials": "N"}, {"family": "Dor", "given": "Yuval", "initials": "Y"}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Elemento", "given": "Olivier", "initials": "O"}, {"family": "Evans", "given": "Georgina", "initials": "G"}, {"family": "Ewels", "given": "Phil", "initials": "P"}, {"family": "Gale", "given": "Joshua", "initials": "J"}, {"family": "Gavrieli", "given": "Amir", "initials": "A"}, {"family": "Geiger", "given": "Benjamin", "initials": "B"}, {"family": "Grad", "given": "Yonatan H", "initials": "YH"}, {"family": "Greene", "given": "Casey S", "initials": "CS"}, {"family": "Hajirasouliha", "given": "Iman", "initials": "I"}, {"family": "Jerala", "given": "Roman", "initials": "R"}, {"family": "Kahles", "given": "Andre", "initials": "A"}, {"family": "Kallioniemi", "given": "Olli", "initials": "O"}, {"family": "Keshet", "given": "Ayya", "initials": "A"}, {"family": "Kocarev", "given": "Ljupco", "initials": "L"}, {"family": "Landua", "given": "Gregory", "initials": "G"}, {"family": "Meir", "given": "Tomer", "initials": "T"}, {"family": "Muller", "given": "Aline", "initials": "A"}, {"family": "Nguyen", "given": "Long H", "initials": "LH"}, {"family": "Oresic", "given": "Matej", "initials": "M"}, {"family": "Ovchinnikova", "given": "Svetlana", "initials": "S"}, {"family": "Peterson", "given": "Hedi", "initials": "H"}, {"family": "Prodanova", "given": "Jana", "initials": "J"}, {"family": "Rajagopal", "given": "Jay", "initials": "J"}, {"family": "R\u00e4tsch", "given": "Gunnar", "initials": "G"}, {"family": "Rossman", "given": "Hagai", "initials": "H"}, {"family": "Rung", "given": "Johan", "initials": "J"}, {"family": "Sboner", "given": "Andrea", "initials": "A"}, {"family": "Sigaras", "given": "Alexandros", "initials": "A"}, {"family": "Spector", "given": "Tim", "initials": "T"}, {"family": "Steinherz", "given": "Ron", "initials": "R"}, {"family": "Stevens", "given": "Irene", "initials": "I"}, {"family": "Vilo", "given": "Jaak", "initials": "J"}, {"family": "Wilmes", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2020-08-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "volume": "26", "issue": "8", "pages": "1161-1165", "issn-l": "1078-8956"}, "abstract": null, "doi": "10.1038/s41591-020-0929-x", "pmid": "32488218", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-020-0929-x"}], "notes": [], "created": "2020-11-19T19:23:03.049Z", "modified": "2020-11-19T19:23:03.069Z"}, {"entity": "publication", "iuid": "023eb43b041b4e50be5765fade3a9d5e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/023eb43b041b4e50be5765fade3a9d5e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/023eb43b041b4e50be5765fade3a9d5e"}}, "title": "Assessing the psychological response to the COVID-19: A response to Bitan et al. \"Fear of COVID-19 scale: Psychometric characteristics, reliability and validity in the Israeli population\".", "authors": [{"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}], "type": "letter", "published": "2020-08-00", "journal": {"title": "Psychiatry Res", "issn": "1872-7123", "volume": "290", "issue": null, "pages": "113127", "issn-l": null}, "abstract": null, "doi": "10.1016/j.psychres.2020.113127", "pmid": "32502825", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0165-1781(20)31547-X"}, {"db": "pmc", "key": "PMC7255140"}], "notes": [], "created": "2020-12-09T10:35:34.375Z", "modified": "2020-12-09T10:35:34.397Z"}, {"entity": "publication", "iuid": "11aa61844aa54c8fb17c8c1c81416cae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/11aa61844aa54c8fb17c8c1c81416cae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/11aa61844aa54c8fb17c8c1c81416cae"}}, "title": "Symptom Relief Is Possible in Elderly Dying COVID-19 Patients: A National Register Study.", "authors": [{"family": "Strang", "given": "Peter", "initials": "P"}, {"family": "Bergstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Lundstr\u00f6m", "given": "Staffan", "initials": "S"}], "type": "journal article", "published": "2020-07-31", "journal": {"title": "J Palliat Med", "issn": "1557-7740", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "Increasing numbers of people dying from COVID-19 are reported, but data are lacking on the way they die. Background: To study symptoms and symptom relief during the last week of life, comparing nursing homes with hospitals. Objective: The Swedish Register of Palliative Care with national coverage was used. Breakthrough symptoms were registered as Yes/No. Symptom relief was recorded on a 3-grade scale as Design: complete-partial-no relief. All deaths in COVID-19 were contrasted to deaths in a reference population (deaths 2019). Deaths at nursing homes were compared with deaths in hospitals. All deaths in hospitals or nursing homes (Setting and Subjects: n = 490) were analyzed. Deaths in other settings (specialized palliative care wards [n = 11], in palliative home care [n = 2], or in their own homes [n = 8]) were excluded (n = 21). Only patients with expected deaths (n = 390) were entered in the final analysis. Breathlessness as a breakthrough symptom was more common in COVID-19 patients than in the 2019 reference population (Results: p < 0.001) and relief of breathlessness, as well as anxiety, delirium, and death rattles was less successful in COVID-19 patients (p < 0.05 to p < 0.01 in different comparisons). Patients were older in nursing homes than in hospitals (86.6 years vs. 80.9 years, p < 0.001) and more often female (48% vs. 34%, p < 0.001). Breakthrough of breathlessness was much more frequently reported in hospital settings than in nursing homes, 73% versus 35% (p < 0.0001), and complete relief was more rarely possible in hospitals, 20% versus 42% (p < 0.01). The proportion of partial relief+complete relief was comparable, 92% versus 95% (ns). Also, anxiety and pain were more often completely relieved in nursing homes (p < 0.01 in both comparisons). The lower symptom prevalence in nursing homes may be explained by elderly frail residents dying already in the first phase of the COVID-19 disease, before acute respiratory distress syndrome develops.Conclusion:", "doi": "10.1089/jpm.2020.0249", "pmid": "32746685", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-07T16:02:24.617Z", "modified": "2022-11-10T07:29:58.676Z"}, {"entity": "publication", "iuid": "afa38fbb53ff4312b9b378bee719af74", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/afa38fbb53ff4312b9b378bee719af74.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/afa38fbb53ff4312b9b378bee719af74"}}, "title": "Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories", "authors": [{"family": "Su", "given": "Yapeng", "initials": "Y"}, {"family": "Chen", "given": "Daniel", "initials": "D"}, {"family": "Lausted", "given": "Christopher", "initials": "C"}, {"family": "Yuan", "given": "Dan", "initials": "D"}, {"family": "Choi", "given": "Jongchan", "initials": "J"}, {"family": "Dai", "given": "Cheng", "initials": "C"}, {"family": "Voillet", "given": "Valentin", "initials": "V"}, {"family": "Scherler", "given": "Kelsey", "initials": "K"}, {"family": "Troisch", "given": "Pamela", "initials": "P"}, {"family": "Duvvuri", "given": "Venkata R", "initials": "VR"}, {"family": "Baloni", "given": "Priyanka", "initials": "P"}, {"family": "Qin", "given": "Guangrong", "initials": "G"}, {"family": "Smith", "given": "Brett", "initials": "B"}, {"family": "Kornilov", "given": "Sergey", "initials": "S"}, {"family": "Rostomily", "given": "Clifford", "initials": "C"}, {"family": "Xu", "given": "Alex", "initials": "A"}, {"family": "Li", "given": "Jing", "initials": "J"}, {"family": "Dong", "given": "Shen", "initials": "S"}, {"family": "Rothchild", "given": "Alissa", "initials": "A"}, {"family": "Zhou", "given": "Jing", "initials": "J"}, {"family": "Murray", "given": "Kim", "initials": "K"}, {"family": "Edmark", "given": "Rick", "initials": "R"}, {"family": "Hong", "given": "Sunga", "initials": "S"}, {"family": "Jones", "given": "Lesley", "initials": "L"}, {"family": "Zhou", "given": "Yong", "initials": "Y"}, {"family": "Roper", "given": "Ryan", "initials": "R"}, {"family": "Mackay", "given": "Sean", "initials": "S"}, {"family": "O\u2019Mahony", "given": "D Shane", "initials": "DS"}, {"family": "Dale", "given": "Christopher R", "initials": "CR"}, {"family": "Wallick", "given": "Julie A", "initials": "JA"}, {"family": "Algren", "given": "Heather A", "initials": "HA"}, {"family": "Michael", "given": "Zager A", "initials": "ZA"}, {"family": "Magis", "given": "Andrew", "initials": "A"}, {"family": "Wei", "given": "Wei", "initials": "W"}, {"family": "Price", "given": "Nathan D", "initials": "ND"}, {"family": "Huang", "given": "Sui", "initials": "S"}, {"family": "Subramanian", "given": "Naeha", "initials": "N"}, {"family": "Wang", "given": "Kai", "initials": "K"}, {"family": "Hadlock", "given": "Jennifer", "initials": "J"}, {"family": "Hood", "given": "Leroy", "initials": "L"}, {"family": "Aderem", "given": "Alan", "initials": "A"}, {"family": "Bluestone", "given": "Jeffrey A", "initials": "JA"}, {"family": "Lanier", "given": "Lewis L", "initials": "LL"}, {"family": "Greenberg", "given": "Phil", "initials": "P"}, {"family": "Gottardo", "given": "Raphael", "initials": "R"}, {"family": "Davis", "given": "Mark M", "initials": "MM"}, {"family": "Goldman", "given": "Jason D", "initials": "JD"}, {"family": "Heath", "given": "James R", "initials": "JR"}, {"family": "None", "given": "", "initials": ""}], "type": "posted-content", "published": "2020-07-28", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.07.27.224063", "pmid": null, "labels": {"Type: Preprint": null, "Category: Genomics & transcriptomics": null}, "xrefs": [{"db": "ArrayExpress", "key": "https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-9357/samples/", "description": "Processed data on samples and derived array files are available on ArrayExpress"}, {"db": "ISB COVID-19 Data Explorer", "key": "https://atlas.fredhutch.org/isb/covid/", "description": "Data integrated for further visualisation and analysis"}, {"db": "NA", "key": "pseudonymized RNA sequencing data available upon request from corresponding author (Due to potential risk of de-identification)", "description": null}], "notes": [], "created": "2021-01-08T08:58:17.158Z", "modified": "2021-11-18T08:28:15.341Z"}, {"entity": "publication", "iuid": "47b56a3f9d6546dc935a3bdbdd4b2315", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/47b56a3f9d6546dc935a3bdbdd4b2315.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/47b56a3f9d6546dc935a3bdbdd4b2315"}}, "title": "Importance of Inclusion of Pregnant and Breastfeeding Women in COVID-19 Therapeutic Trials.", "authors": [{"family": "LaCourse", "given": "Sylvia", "initials": "S"}, {"family": "John-Stewart", "given": "Grace", "initials": "G"}, {"family": "Adams Waldorf", "given": "Kristina M", "initials": "KM"}], "type": "journal article", "published": "2020-07-28", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "volume": "71", "issue": "15", "pages": "879-881", "issn-l": "1058-4838"}, "abstract": "Investigators are employing unprecedented innovation in the design of clinical trials to rapidly and rigorously assess potentially promising therapies for coronavirus disease 2019 (COVID-19); this is in stark contrast to the continued near-universal regressive practice of exclusion of pregnant and breastfeeding women from these trials. The few trials that allow their inclusion focus on postexposure prophylaxis or outpatient treatment of milder disease, limiting the options available to pregnant women with severe COVID-19 to compassionate use of remdesivir, or off-label drug use of hydroxychloroquine or other therapies. These restrictions were put in place despite experience with these drugs in pregnant women. In this Viewpoint, we call attention to the need and urgency to engage pregnant women in COVID-19 treatment trials now in order to develop data-driven recommendations regarding the risks and benefits of therapies in this unique but not uncommon population.", "doi": "10.1093/cid/ciaa444", "pmid": "32296817", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5820683"}, {"db": "pmc", "key": "PMC7184504"}], "notes": [], "created": "2020-12-09T14:47:38.472Z", "modified": "2020-12-09T14:47:38.490Z"}, {"entity": "publication", "iuid": "df6d1ea6bc7443daabbea5f510146e0d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/df6d1ea6bc7443daabbea5f510146e0d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/df6d1ea6bc7443daabbea5f510146e0d"}}, "title": "Generalizability of Coronavirus Disease 2019 (COVID-19) Clinical Prediction Models.", "authors": [{"family": "Hooli", "given": "Shubhada", "initials": "S"}, {"family": "King", "given": "Carina", "initials": "C"}], "type": "letter", "published": "2020-07-28", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "volume": "71", "issue": "15", "pages": "897", "issn-l": "1058-4838"}, "abstract": null, "doi": "10.1093/cid/ciaa417", "pmid": "32271865", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5818447"}, {"db": "pmc", "key": "PMC7184363"}], "notes": [], "created": "2020-11-22T17:15:23.515Z", "modified": "2020-11-22T17:15:23.526Z"}, {"entity": "publication", "iuid": "97538cd2ee6649578f2a9df8210012f6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/97538cd2ee6649578f2a9df8210012f6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/97538cd2ee6649578f2a9df8210012f6"}}, "title": "Computational Studies of SARS-CoV-2 3CLpro: Insights from MD Simulations.", "authors": [{"family": "Grottesi", "given": "Alessandro", "initials": "A"}, {"family": "Be\u0161ker", "given": "Neva", "initials": "N"}, {"family": "Emerson", "given": "Andrew", "initials": "A"}, {"family": "Manelfi", "given": "Candida", "initials": "C"}, {"family": "Beccari", "given": "Andrea R", "initials": "AR"}, {"family": "Frigerio", "given": "Francesco", "initials": "F"}, {"family": "Lindahl", "given": "Erik", "initials": "E"}, {"family": "Cerchia", "given": "Carmen", "initials": "C"}, {"family": "Talarico", "given": "Carmine", "initials": "C"}], "type": "journal article", "published": "2020-07-28", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "21", "issue": "15", "issn-l": null}, "abstract": "Given the enormous social and health impact of the pandemic triggered by severe acute respiratory syndrome 2 (SARS-CoV-2), the scientific community made a huge effort to provide an immediate response to the challenges posed by Coronavirus disease 2019 (COVID-19). One of the most important proteins of the virus is an enzyme, called 3CLpro or main protease, already identified as an important pharmacological target also in SARS and Middle East respiratory syndrome virus (MERS) viruses. This protein triggers the production of a whole series of enzymes necessary for the virus to carry out its replicating and infectious activities. Therefore, it is crucial to gain a deeper understanding of 3CLpro structure and function in order to effectively target this enzyme. All-atoms molecular dynamics (MD) simulations were performed to examine the different conformational behaviors of the monomeric and dimeric form of SARS-CoV-2 3CLpro apo structure, as revealed by microsecond time scale MD simulations. Our results also shed light on the conformational dynamics of the loop regions at the entry of the catalytic site. Studying, at atomic level, the characteristics of the active site and obtaining information on how the protein can interact with its substrates will allow the design of molecules able to block the enzymatic function crucial for the virus.", "doi": "10.3390/ijms21155346", "pmid": "32731361", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Imaging": null}, "xrefs": [{"db": "pii", "key": "ijms21155346"}, {"db": "pmc", "key": "PMC7432786"}], "notes": [], "created": "2020-12-07T16:07:31.972Z", "modified": "2021-02-26T08:45:36.635Z"}, {"entity": "publication", "iuid": "e7c8cb8687554ac194841f84f0afae33", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e7c8cb8687554ac194841f84f0afae33.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e7c8cb8687554ac194841f84f0afae33"}}, "title": "Review of guidelines and recommendations from 17 countries highlights the challenges that clinicians face caring for neonates born to mothers with COVID-19.", "authors": [{"family": "Yeo", "given": "Kee Thai", "initials": "KT"}, {"family": "Oei", "given": "Ju Lee", "initials": "JL"}, {"family": "De Luca", "given": "Daniele", "initials": "D"}, {"family": "Schm\u00f6lzer", "given": "Georg M", "initials": "GM"}, {"family": "Guaran", "given": "Robert", "initials": "R"}, {"family": "Palasanthiran", "given": "Pamela", "initials": "P"}, {"family": "Kumar", "given": "Kishore", "initials": "K"}, {"family": "Buonocore", "given": "Giuseppe", "initials": "G"}, {"family": "Cheong", "given": "Jeanie", "initials": "J"}, {"family": "Owen", "given": "Louise S", "initials": "LS"}, {"family": "Kusuda", "given": "Satoshi", "initials": "S"}, {"family": "James", "given": "Jennifer", "initials": "J"}, {"family": "Lim", "given": "Gina", "initials": "G"}, {"family": "Sharma", "given": "Ankur", "initials": "A"}, {"family": "Uthaya", "given": "Sabita", "initials": "S"}, {"family": "Gale", "given": "Christopher", "initials": "C"}, {"family": "Whittaker", "given": "Elizabeth", "initials": "E"}, {"family": "Battersby", "given": "Cheryl", "initials": "C"}, {"family": "Modi", "given": "Neena", "initials": "N"}, {"family": "Norman", "given": "Mikael", "initials": "M"}, {"family": "Naver", "given": "Lars", "initials": "L"}, {"family": "Giannoni", "given": "Eric", "initials": "E"}, {"family": "Diambomba", "given": "Yenge", "initials": "Y"}, {"family": "Shah", "given": "Prakeshkumar S", "initials": "PS"}, {"family": "Gagliardi", "given": "Luigi", "initials": "L"}, {"family": "Harrison", "given": "Michael", "initials": "M"}, {"family": "Pillay", "given": "Shakti", "initials": "S"}, {"family": "Alburaey", "given": "Abdullah", "initials": "A"}, {"family": "Yuan", "given": "Yuan", "initials": "Y"}, {"family": "Zhang", "given": "Huayan", "initials": "H"}], "type": "journal article", "published": "2020-07-27", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "volume": null, "issue": null, "issn-l": null}, "abstract": "This review examined how applicable national and regional clinical practice guidelines and recommendations for managing neonates born to mothers with COVID-19 mothers were to the evolving pandemic.\n\nA systematic search and review identified 20 guidelines and recommendations that had been published by May 25, 2020. We analysed documents from 17 countries: Australia, Brazil, Canada, China, France, India, Italy, Japan, Saudi Arabia, Singapore, South Africa, South Korea, Spain, Sweden, Switzerland, the UK and the United States.\n\nThe documents were based on expert consensus with limited evidence and were of variable, low methodological rigour. Most did not provide recommendations for delivery methods or managing symptomatic infants. None provided recommendations for post-discharge assimilation of potentially infected infants into the community. The majority encouraged keeping mothers and infants together, subject to infection control measures, but one-third recommended separation. Although breastfeeding or using breastmilk was widely encouraged, two countries specifically prohibited this.\n\nThe guidelines and recommendations for managing infants affected by COVID-19 were of low, variable quality and may be unsustainable. It is important that transmission risks are not increased when new information is incorporated into clinical recommendations. Practice guidelines should emphasise the extent of uncertainty and clearly define gaps in the evidence.", "doi": "10.1111/apa.15495", "pmid": "32716579", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-26T12:17:38.777Z", "modified": "2020-11-30T08:44:14.646Z"}, {"entity": "publication", "iuid": "871f7354d16c4d1ca89d4b422bd909c6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/871f7354d16c4d1ca89d4b422bd909c6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/871f7354d16c4d1ca89d4b422bd909c6"}}, "title": "Efficacy of Corticosteroids in Patients with SARS, MERS and COVID-19: A Systematic Review and Meta-Analysis.", "authors": [{"family": "Lee", "given": "Keum Hwa", "initials": "KH"}, {"family": "Yoon", "given": "Sojung", "initials": "S"}, {"family": "Jeong", "given": "Gwang Hun", "initials": "GH"}, {"family": "Kim", "given": "Jong Yeob", "initials": "JY"}, {"family": "Han", "given": "Young Joo", "initials": "YJ"}, {"family": "Hong", "given": "Sung Hwi", "initials": "SH"}, {"family": "Ryu", "given": "Seohyun", "initials": "S"}, {"family": "Kim", "given": "Jae Seok", "initials": "JS"}, {"family": "Lee", "given": "Jun Young", "initials": "JY"}, {"family": "Yang", "given": "Jae Won", "initials": "JW"}, {"family": "Lee", "given": "Jinhee", "initials": "J"}, {"family": "Solmi", "given": "Marco", "initials": "M"}, {"family": "Koyanagi", "given": "Ai", "initials": "A"}, {"family": "Dragioti", "given": "Elena", "initials": "E"}, {"family": "Jacob", "given": "Louis", "initials": "L"}, {"family": "Radua", "given": "Joaquim", "initials": "J"}, {"family": "Smith", "given": "Lee", "initials": "L"}, {"family": "Oh", "given": "Hans", "initials": "H"}, {"family": "Tizaoui", "given": "Kalthoum", "initials": "K"}, {"family": "Cargnin", "given": "Sarah", "initials": "S"}, {"family": "Terrazzino", "given": "Salvatore", "initials": "S"}, {"family": "Ghayda", "given": "Ramy Abou", "initials": "RA"}, {"family": "Kronbichler", "given": "Andreas", "initials": "A"}, {"family": "Shin", "given": "Jae Il", "initials": "JI"}], "type": "journal article", "published": "2020-07-27", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "9", "issue": "8", "issn-l": "2077-0383"}, "abstract": "(1) Background: The use of corticosteroids in critical coronavirus infections, including severe acute respiratory syndrome (SARS), Middle East Respiratory Syndrome (MERS), or Coronavirus disease 2019 (COVID-19), has been controversial. However, a meta-analysis on the efficacy of steroids in treating these coronavirus infections is lacking. (2) Purpose: We assessed a methodological criticism on the quality of previous published meta-analyses and the risk of misleading conclusions with important therapeutic consequences. We also examined the evidence of the efficacy of corticosteroids in reducing mortality in SARS, MERS and COVID-19. (3) Methods: PubMed, MEDLINE, Embase, and Web of Science were used to identify studies published until 25 April 2020, that reported associations between steroid use and mortality in treating SARS/MERS/COVID-19. Two investigators screened and extracted data independently. Searches were restricted to studies on humans, and articles that did not report the exact number of patients in each group or data on mortality were excluded. We calculated odds ratios (ORs) or hazard ratios (HRs) under the fixed- and random-effect model. (4) Results: Eight articles (4051 patients) were eligible for inclusion. Among these selected studies, 3416 patients were diagnosed with SARS, 360 patients with MERS, and 275 with COVID-19; 60.3% patients were administered steroids. The meta-analyses including all studies showed no differences overall in terms of mortality (OR 1.152, 95% CI 0.631-2.101 in the random effects model, p = 0.645). However, this conclusion might be biased, because, in some studies, the patients in the steroid group had more severe symptoms than those in the control group. In contrast, when the meta-analysis was performed restricting only to studies that used appropriate adjustment (e.g., time, disease severity), there was a significant difference between the two groups (HR 0.378, 95% CI 0.221-0.646 in the random effects model, p < 0.0001). Although there was no difference in mortality when steroids were used in severe cases, there was a difference among the group with more underlying diseases (OR 3.133, 95% CI 1.670-5.877, p < 0.001). (5) Conclusions: To our knowledge, this study is the first comprehensive systematic review and meta-analysis providing the most accurate evidence on the effect of steroids in coronavirus infections. If not contraindicated, and in the absence of side effects, the use of steroids should be considered in coronavirus infection including COVID-19.", "doi": "10.3390/jcm9082392", "pmid": "32726951", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jcm9082392"}, {"db": "pmc", "key": "PMC7465945"}], "notes": [], "created": "2020-11-26T12:15:27.760Z", "modified": "2020-11-30T08:44:13.309Z"}, {"entity": "publication", "iuid": "d94b8fd3ab114fbab0ca35902c0364b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d94b8fd3ab114fbab0ca35902c0364b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d94b8fd3ab114fbab0ca35902c0364b3"}}, "title": "Compliance to Recommendations and Mental Health Consequences among Elderly in Sweden during the Initial Phase of the COVID-19 Pandemic-A Cross Sectional Online Survey.", "authors": [{"family": "Gustavsson", "given": "Johanna", "initials": "J"}, {"family": "Beckman", "given": "Linda", "initials": "L"}], "type": "journal article", "published": "2020-07-26", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "15", "pages": "5380"}, "abstract": "Background (1): In the wake of COVID-19, elderly people have been labelled a risk group. As the pandemic is a new crisis in Sweden, we have no knowledge on how this group perceives the information and recommendations being provided. Complying with these recommendations entails physical distancing and, for some, isolation at home. Methods (2): From 16 April to 15 May 2020, we conducted an online survey targeting people aged 70 and older in Sweden (n = 1854). Results (3): A vast majority of the participants find the information and recommendations clear and reliable. Half of the participants report staying at home all the time, and up to half report decreased mental health in terms of, e.g., feeling depressed, having sleeping problems and that isolation makes them feel bad. However, elderly people are not a homogenous group, and there are gender and demographic differences. (4) Conclusion: At this point, we do not know the full extent of the ongoing pandemic, either in terms of duration or in terms of losses. The Swedish model for action on COVID-19 has not included a lock down. However, elderly people seem to comply with recommendations and practice social distancing to a high degree. This might lead to decreased mental health and long-term effects.", "doi": "10.3390/ijerph17155380", "pmid": "32722624", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7432611"}, {"db": "pii", "key": "ijerph17155380"}], "notes": [], "created": "2020-12-07T16:08:58.764Z", "modified": "2023-06-19T14:51:29.461Z"}, {"entity": "publication", "iuid": "237450facd3243e6a1f106b316d527f3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/237450facd3243e6a1f106b316d527f3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/237450facd3243e6a1f106b316d527f3"}}, "title": "Current Status of COVID-19 Therapies and Drug Repositioning Applications.", "authors": [{"family": "Altay", "given": "Ozlem", "initials": "O"}, {"family": "Mohammadi", "given": "Elyas", "initials": "E"}, {"family": "Lam", "given": "Simon", "initials": "S", "orcid": "0000-0002-4476-0971", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/89c92490f9c747da8af1c28fc155ac8a.json"}}, {"family": "Turkez", "given": "Hasan", "initials": "H"}, {"family": "Boren", "given": "Jan", "initials": "J"}, {"family": "Nielsen", "given": "Jens", "initials": "J", "orcid": "0000-0002-9955-6003", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f4b76d85efe148889e8a33aa78a75c87.json"}}, {"family": "Uhlen", "given": "Mathias", "initials": "M"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb9f5331ce524497923b4d7044bed6a8.json"}}], "type": "journal article", "published": "2020-07-24", "journal": {"title": "iScience", "issn": "2589-0042", "issn-l": "2589-0042", "volume": "23", "issue": "7", "pages": "101303"}, "abstract": "The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19. Drug repositioning is an attractive approach that can facilitate the drug discovery process by repurposing existing pharmaceuticals to treat illnesses other than their primary indications. Here, we review current information concerning the global health issue of COVID-19 including promising approved drugs and ongoing clinical trials for prospective treatment options. In addition, we describe computational approaches to be used in drug repurposing and highlight examples of in silico studies of drug development efforts against SARS-CoV-2.", "doi": "10.1016/j.isci.2020.101303", "pmid": "32622261", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2589-0042(20)30490-9"}, {"db": "pmc", "key": "PMC7305759"}], "notes": [], "created": "2020-11-04T13:11:37.791Z", "modified": "2021-06-22T13:25:22.943Z"}, {"entity": "publication", "iuid": "7e6dbde8bcd14d81a72d07014d95c74e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7e6dbde8bcd14d81a72d07014d95c74e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7e6dbde8bcd14d81a72d07014d95c74e"}}, "title": "Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection.", "authors": [{"family": "Messner", "given": "Christoph B", "initials": "CB"}, {"family": "Demichev", "given": "Vadim", "initials": "V"}, {"family": "Wendisch", "given": "Daniel", "initials": "D"}, {"family": "Michalick", "given": "Laura", "initials": "L"}, {"family": "White", "given": "Matthew", "initials": "M"}, {"family": "Freiwald", "given": "Anja", "initials": "A"}, {"family": "Textoris-Taube", "given": "Kathrin", "initials": "K"}, {"family": "Vernardis", "given": "Spyros I", "initials": "SI"}, {"family": "Egger", "given": "Anna-Sophia", "initials": "A"}, {"family": "Kreidl", "given": "Marco", "initials": "M"}, {"family": "Ludwig", "given": "Daniela", "initials": "D"}, {"family": "Kilian", "given": "Christiane", "initials": "C"}, {"family": "Agostini", "given": "Federica", "initials": "F"}, {"family": "Zelezniak", "given": "Aleksej", "initials": "A"}, {"family": "Thibeault", "given": "Charlotte", "initials": "C"}, {"family": "Pfeiffer", "given": "Moritz", "initials": "M"}, {"family": "Hippenstiel", "given": "Stefan", "initials": "S"}, {"family": "Hocke", "given": "Andreas", "initials": "A"}, {"family": "von Kalle", "given": "Christof", "initials": "C"}, {"family": "Campbell", "given": "Archie", "initials": "A"}, {"family": "Hayward", "given": "Caroline", "initials": "C"}, {"family": "Porteous", "given": "David J", "initials": "DJ"}, {"family": "Marioni", "given": "Riccardo E", "initials": "RE"}, {"family": "Langenberg", "given": "Claudia", "initials": "C"}, {"family": "Lilley", "given": "Kathryn S", "initials": "KS"}, {"family": "Kuebler", "given": "Wolfgang M", "initials": "WM"}, {"family": "M\u00fclleder", "given": "Michael", "initials": "M"}, {"family": "Drosten", "given": "Christian", "initials": "C"}, {"family": "Suttorp", "given": "Norbert", "initials": "N"}, {"family": "Witzenrath", "given": "Martin", "initials": "M"}, {"family": "Kurth", "given": "Florian", "initials": "F"}, {"family": "Sander", "given": "Leif Erik", "initials": "LE"}, {"family": "Ralser", "given": "Markus", "initials": "M"}], "type": "journal article", "published": "2020-07-22", "journal": {"title": "Cell Syst", "issn": "2405-4720", "issn-l": null, "volume": "11", "issue": "1", "pages": "11-24.e4"}, "abstract": "The COVID-19 pandemic is an unprecedented global challenge, and point-of-care diagnostic classifiers are urgently required. Here, we present a platform for ultra-high-throughput serum and plasma proteomics that builds on ISO13485 standardization to facilitate simple implementation in regulated clinical laboratories. Our low-cost workflow handles up to 180 samples per day, enables high precision quantification, and reduces batch effects for large-scale and longitudinal studies. We use our platform on samples collected from a cohort of early hospitalized cases of the SARS-CoV-2 pandemic and identify 27 potential biomarkers that are differentially expressed depending on the WHO severity grade of COVID-19. They include complement factors, the coagulation system, inflammation modulators, and pro-inflammatory factors upstream and downstream of interleukin 6. All protocols and software for implementing our approach are freely available. In total, this work supports the development of routine proteomic assays to aid clinical decision making and generate hypotheses about potential COVID-19 therapeutic targets.", "doi": "10.1016/j.cels.2020.05.012", "pmid": "32619549", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Proteins": null, "Category: Serology": null}, "xrefs": [{"db": "pii", "key": "S2405-4712(20)30197-6"}, {"db": "pmc", "key": "PMC7264033"}], "notes": [], "created": "2020-12-08T15:06:05.260Z", "modified": "2022-11-10T07:33:00.728Z"}, {"entity": "publication", "iuid": "ff6f8d98da824a7d8c7ab483aeade546", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ff6f8d98da824a7d8c7ab483aeade546.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ff6f8d98da824a7d8c7ab483aeade546"}}, "title": "Substance Use Disorders and COVID-19: Multi-Faceted Problems Which Require Multi-Pronged Solutions.", "authors": [{"family": "Jemberie", "given": "Wossenseged Birhane", "initials": "WB"}, {"family": "Stewart Williams", "given": "Jennifer", "initials": "J"}, {"family": "Eriksson", "given": "Malin", "initials": "M"}, {"family": "Gr\u00f6nlund", "given": "Ann-Sofie", "initials": "AS"}, {"family": "Ng", "given": "Nawi", "initials": "N"}, {"family": "Blom Nilsson", "given": "Marcus", "initials": "M"}, {"family": "Padyab", "given": "Mojgan", "initials": "M"}, {"family": "Priest", "given": "Kelsey Caroline", "initials": "KC"}, {"family": "Sandlund", "given": "Mikael", "initials": "M"}, {"family": "Snellman", "given": "Fredrik", "initials": "F"}, {"family": "McCarty", "given": "Dennis", "initials": "D"}, {"family": "Lundgren", "given": "Lena M", "initials": "LM"}], "type": "journal article", "published": "2020-07-21", "journal": {"title": "Front Psychiatry", "issn": "1664-0640", "volume": "11", "issue": null, "pages": "714", "issn-l": "1664-0640"}, "abstract": "COVID-19 shocked health and economic systems leaving millions of people without employment and safety nets. The pandemic disproportionately affects people with substance use disorders (SUDs) due to the collision between SUDs and COVID-19. Comorbidities and risk environments for SUDs are likely risk factors for COVID-19. The pandemic, in turn, diminishes resources that people with SUD need for their recovery and well-being. This article presents an interdisciplinary and international perspective on how COVID-19 and the related systemic shock impact on individuals with SUDs directly and indirectly. We highlight a need to understand SUDs as biopsychosocial disorders and use evidence-based policies to destigmatize SUDs. We recommend a suite of multi-sectorial actions and strategies to strengthen, modernize and complement addiction care systems which will become resilient and responsive to future systemic shocks similar to the COVID-19 pandemic.", "doi": "10.3389/fpsyt.2020.00714", "pmid": "32848907", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7396653"}], "notes": [], "created": "2020-12-07T10:23:23.099Z", "modified": "2020-12-07T10:23:40.294Z"}, {"entity": "publication", "iuid": "10054aad3a5c4b87aef56f880a53e7d5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/10054aad3a5c4b87aef56f880a53e7d5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/10054aad3a5c4b87aef56f880a53e7d5"}}, "title": "Non-Bacterial Thrombotic Endocarditis: A Presentation of COVID-19.", "authors": [{"family": "Balata", "given": "Dilan", "initials": "D"}, {"family": "Mellerg\u00e5rd", "given": "Johan", "initials": "J"}, {"family": "Ekqvist", "given": "David", "initials": "D"}, {"family": "Baranowski", "given": "Jacek", "initials": "J"}, {"family": "Garcia", "given": "Isidro Albert", "initials": "IA"}, {"family": "Volosyraki", "given": "Marina", "initials": "M"}, {"family": "Broqvist", "given": "Mats", "initials": "M"}], "type": "journal article", "published": "2020-07-21", "journal": {"title": "Eur J Case Rep Intern Med", "issn": "2284-2594", "volume": "7", "issue": "8", "pages": "001811", "issn-l": null}, "abstract": "The SARS-CoV-2 virus is a newly emergent pathogen first identified in Wuhan, China, and responsible for the COVID-19 global pandemic. In this case report we describe a manifestation of non-bacterial thrombotic endocarditis with continuous peripheral embolization in a COVID-19-positive patient. The patient responded well to high-dose LMWH treatment with cessation of the embolic process.\n\nRaising awareness of possible complications of COVID-19.To highlight the importance of the careful consideration of and dosage of anticoagulation in non-bacterial thrombotic endocarditis.", "doi": "10.12890/2020_001811", "pmid": "32789144", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "1811-1-15256-1-10-20200720"}, {"db": "pmc", "key": "PMC7417053"}], "notes": [], "created": "2020-12-07T13:26:39.296Z", "modified": "2020-12-07T13:26:52.483Z"}, {"entity": "publication", "iuid": "f7fa3b5f385f4911885bc7374541634f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7fa3b5f385f4911885bc7374541634f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7fa3b5f385f4911885bc7374541634f"}}, "title": "Multidisciplinary Tracheostomy Quality Improvement in the COVID-19 Pandemic: Building a Global Learning Community.", "authors": [{"family": "Swords", "given": "Chloe", "initials": "C"}, {"family": "Bergman", "given": "Lina", "initials": "L"}, {"family": "Wilson-Jeffers", "given": "Rachel", "initials": "R"}, {"family": "Randall", "given": "Diane", "initials": "D"}, {"family": "Morris", "given": "Linda L", "initials": "LL"}, {"family": "Brenner", "given": "Michael J", "initials": "MJ"}, {"family": "Arora", "given": "Asit", "initials": "A"}], "type": "journal article", "published": "2020-07-17", "journal": {"title": "Ann Otol Rhinol Laryngol", "issn": "1943-572X", "volume": null, "issue": null, "pages": "3489420941542", "issn-l": null}, "abstract": "To report experience with a global multidisciplinary tracheostomy e-learning initiative.\n\nAn international multidisciplinary panel of experts convened to build a virtual learning community for tracheostomy care, comprising a web-based platform, five distance learning (interactive webinar) sessions, and professional discourse over 12 months. Structured pre- and post-webinar surveys were disseminated to global participants including otolaryngologists, intensivists, nurses, allied health professionals, and patients/caregivers. Data were collected on audio-visual fidelity, demographics, and pre- and post-tutorial assessments regarding experience and skill acquisition. Participants reported confidence levels for NICU, pediatric, adult, and family care, as well as technical skills, communication, learning, assessment, and subdomains.\n\nParticipants from 197 institutions in 22 countries engaged in the virtual education platform, including otolaryngologists, speech pathologists, respiratory therapists, specialist nurses, patients, and caregivers. Significant improvements were reported in communication ( P < .0001), clinical assessments (P < .0001), and clinical governance (P < .0001), with positive impact on pediatric decannulation (P = .0008), adult decannulation (P = .04), and quality improvement (P < .0001). Respondents reported enhanced readiness to integrate knowledge into practice. Barriers included time zones, internet bandwidth, and perceived difficulty of direct clinical translation of highly technical skills. Participants rated the implementation highly in terms of length, ability for discussion, satisfaction, applicability to professional practice, and expertise of discussants (median scores: 4, 4, 4, 4 and 5 out of 5).\n\nVirtual learning has dominated the education landscape during COVID-19 pandemic, but few data are available on its effectiveness. This study demonstrated feasibility of virtual learning for disseminating best practices in tracheostomy, engaging a diverse, multidisciplinary audience. Learning of complex technical skills proved a hurdle, however, suggesting need for hands-on experience for technical mastery. While interactive videoconferencing via webinar affords an engaging and scalable strategy for sharing knowledge, further investigation is needed on clinical outcomes to define effective strategies for experiential online learning and virtual in-service simulations.", "doi": "10.1177/0003489420941542", "pmid": "32680435", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7369399"}], "notes": [], "created": "2020-12-07T16:32:06.801Z", "modified": "2020-12-07T16:33:54.718Z"}, {"entity": "publication", "iuid": "1d34255c1b8d4bde8b603828a8fc2bc8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1d34255c1b8d4bde8b603828a8fc2bc8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1d34255c1b8d4bde8b603828a8fc2bc8"}}, "title": "Role of Environmental Temperature on the Attack rate and Case fatality rate of Coronavirus Disease 2019 (COVID-19) Pandemic.", "authors": [{"family": "Hassan", "given": "Mohammad M", "initials": "MM"}, {"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME"}, {"family": "Khan", "given": "Shahneaz A", "initials": "SA"}, {"family": "Islam", "given": "Ariful", "initials": "A"}, {"family": "Nayem", "given": "Md Raihan K", "initials": "MRK"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}], "type": "journal article", "published": "2020-07-16", "journal": {"title": "Infect Ecol Epidemiol", "issn": "2000-8686", "volume": "10", "issue": "1", "pages": "1792620", "issn-l": "2000-8686"}, "abstract": "SARS-CoV-2 is a zoonotic Betacoronavirus causing the devastating COVID-19 pandemic. More than twelve million COVID-19 cases and 500 thousand fatalities have been reported in 216 countries. Although SARS-CoV-2 originated in China, comparatively fewer people have been affected in other Asian countries than in Europe and the USA. This study examined the hypothesis that lower temperature may increase the spread of SARS-CoV-2 by comparing attack rate and case fatality rate (until 21 March 2020) to mean temperature in January-February 2020. The attack rate was highest in Luxembourg followed by Italy and Switzerland. There was a significant (p = 0.02) correlation between decreased attack rate and increased environmental temperature. The case fatality rate was highest in Italy followed by Iran and Spain. There was no significant correlation between the case fatality rate and temperature. This study indicates that lower temperature may increase SARS-CoV-2 transmission (measured as an increased attack rate), but there is no evidence that temperature affects the severity of the disease (measured as case fatality rate). However, there are clearly other factors that affect the transmission of SARS-CoV-2, and many of these may be sensitive to interventions, e.g. through increased public awareness and public health response.", "doi": "10.1080/20008686.2020.1792620", "pmid": "32944163", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "1792620"}, {"db": "pmc", "key": "PMC7480504"}], "notes": [], "created": "2020-11-18T17:34:57.249Z", "modified": "2021-02-26T08:46:12.968Z"}, {"entity": "publication", "iuid": "c23bcab33a00461ca27d92a08ead96cf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c23bcab33a00461ca27d92a08ead96cf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c23bcab33a00461ca27d92a08ead96cf"}}, "title": "Repurposing CD8 + T cell immunity against SARS-CoV-2 for cancer immunotherapy: a positive aspect of the COVID-19 pandemic?", "authors": [{"family": "Gujar", "given": "Shashi", "initials": "S"}, {"family": "Pol", "given": "Jonathan G", "initials": "JG"}, {"family": "Kim", "given": "Youra", "initials": "Y"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}], "type": "journal article", "published": "2020-07-16", "journal": {"title": "Oncoimmunology", "issn": "2162-4011", "volume": "9", "issue": "1", "pages": "1794424", "issn-l": null}, "abstract": "The COVID-19 pandemic has afflicted most countries on the planet. As a result, immunity against SARS-CoV-2, induced via natural infections or imminent vaccinations, is expected to develop in a large fraction of the global population. Here, we propose to exploit SARS-CoV-2-specific CD8 + T cells for cancer immunotherapy strategies.", "doi": "10.1080/2162402X.2020.1794424", "pmid": "32923158", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "1794424"}, {"db": "pmc", "key": "PMC7458627"}], "notes": [], "created": "2020-11-26T12:31:06.390Z", "modified": "2020-11-26T12:31:06.401Z"}, {"entity": "publication", "iuid": "19037d975bdc46d69a046a10002818f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/19037d975bdc46d69a046a10002818f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/19037d975bdc46d69a046a10002818f0"}}, "title": "Effect of statins on SARS-CoV-2 infection", "authors": [{"family": "Moeller", "given": "Rebecca", "initials": "R"}, {"family": "Zapatero-Belinch\u00f3n", "given": "Francisco J", "initials": "FJ"}, {"family": "Lasswitz", "given": "Lisa", "initials": "L"}, {"family": "Kirui", "given": "Jared", "initials": "J"}, {"family": "Brogden", "given": "Graham", "initials": "G"}, {"family": "Gunesch", "given": "Antonia P", "initials": "AP"}, {"family": "Pietschmann", "given": "Thomas", "initials": "T"}, {"family": "Wichmann", "given": "Dominic", "initials": "D"}, {"family": "Kluge", "given": "Stefan", "initials": "S"}, {"family": "Gerold", "given": "Gisa", "initials": "G", "orcid": "0000-0002-1326-5038", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/39af3df98cf14f96baa155798617841b.json"}}], "type": "posted-content", "published": "2020-07-14", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.07.13.20152272", "pmid": null, "labels": {"Funder: KAW/SciLifeLab": null, "Type: Preprint": null, "Research Area: Host cell systems biology and targets": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-15T16:41:57.170Z", "modified": "2022-11-22T05:52:24.479Z"}, {"entity": "publication", "iuid": "61c4d6c1a504486f9ab36320ec38bdd3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/61c4d6c1a504486f9ab36320ec38bdd3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/61c4d6c1a504486f9ab36320ec38bdd3"}}, "title": "Discriminative Bayesian Serology: Counting Without Cutoffs", "authors": [{"family": "Christian", "given": "Murray", "initials": "M"}, {"family": "Murrell", "given": "Ben", "initials": "B", "orcid": "0000-0002-0393-4445", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/60dac9ecf84d4eb3b90fb4ee1298bc52.json"}}], "type": "posted-content", "published": "2020-07-14", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.07.14.202150", "pmid": null, "labels": {"Type: Preprint": null, "Funder: H2020": null, "Category: Other": null, "Category: Serology": null}, "xrefs": [], "notes": [], "created": "2021-01-08T09:00:29.416Z", "modified": "2022-11-10T07:33:32.183Z"}, {"entity": "publication", "iuid": "e541e41eb72f48c6989a921a797b6bd8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e541e41eb72f48c6989a921a797b6bd8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e541e41eb72f48c6989a921a797b6bd8"}}, "title": "Covid-19: an opportunity to reduce unnecessary healthcare.", "authors": [{"family": "Moynihan", "given": "Ray", "initials": "R"}, {"family": "Johansson", "given": "Minna", "initials": "M"}, {"family": "Maybee", "given": "Alies", "initials": "A"}, {"family": "Lang", "given": "Eddy", "initials": "E"}, {"family": "L\u00e9gar\u00e9", "given": "France", "initials": "F"}], "type": "editorial", "published": "2020-07-14", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "370", "issue": null, "pages": "m2752", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m2752", "pmid": "32665257", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-08T10:41:40.545Z", "modified": "2020-12-08T10:41:40.554Z"}, {"entity": "publication", "iuid": "14a924a1edb949dc91ae4e6f9e35714c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/14a924a1edb949dc91ae4e6f9e35714c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/14a924a1edb949dc91ae4e6f9e35714c"}}, "title": "An immunotherapeutic method for COVID-19 patients: a soluble ACE2-Anti-CD16 VHH to block SARS-CoV-2 Spike protein.", "authors": [{"family": "Sheikhi", "given": "Abdolkarim", "initials": "A"}, {"family": "Hojjat-Farsangi", "given": "Mohammad", "initials": "M"}], "type": "journal article", "published": "2020-07-14", "journal": {"title": "Hum Vaccin Immunother", "issn": "2164-554X", "issn-l": null, "volume": null, "issue": null, "pages": "1-6"}, "abstract": "The third outbreak of coronavirus (CoV) infection (after SARS-CoV and MERS-CoV) caused by a novel CoV (SARS-CoV-2) of the genus Beta-coronavirus has become a global pandemic. CoVs are enveloped viruses whose proteins include spike (S), membrane (M), and envelope (E) which are embedded in the viral envelope. The glycosylated S protein, which forms homo-trimeric spikes on the surface of the viral particle, mediates viral entry into host cells. SARS-CoV-2, like SARS-CoV, uses the Angiotensin-Converting Enzyme 2 (ACE2) cell surface protein for cellular entry. An attractive anti-viral approach is targeting virus entry into cells, for which three strategies are suggested: 1) direct targeting of the viral glycoprotein; 2) targeting the viral receptor on the cell surface; and 3) using soluble (s) ACE2 that binds to S protein thereby neutralizing the virus. In this article, the advantages and disadvantages of these strategies are explained. Moreover, we propose that fusion of the sACE2 to anti-CD16 to produce a bi-speci\ufb01c molecule could be a promising anti-viral strategy.", "doi": "10.1080/21645515.2020.1787066", "pmid": "32663051", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-08T10:42:25.787Z", "modified": "2020-12-08T10:42:53.471Z"}, {"entity": "publication", "iuid": "097a76b78d194ee4b04ef819bfdb543c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/097a76b78d194ee4b04ef819bfdb543c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/097a76b78d194ee4b04ef819bfdb543c"}}, "title": "Misinformation and de-contextualization: international media reporting on Sweden and COVID-19.", "authors": [{"family": "Irwin", "given": "Rachel Elisabeth", "initials": "RE"}], "type": "journal article", "published": "2020-07-13", "journal": {"title": "Global Health", "issn": "1744-8603", "volume": "16", "issue": "1", "pages": "62", "issn-l": "1744-8603"}, "abstract": "In the first month of the 2020 COVID-19 pandemic, Sweden took the same strategy as most other countries, working to \"flatten the curve,\" by slowing transmission so that the healthcare system could cope with the disease. However, unlike most other countries, much of Sweden's implementation focused on voluntary and stepwise action, rather than legislation and compulsory measures, leading to considerable attention in the international media.Six main narratives emerged in the international media reporting on Sweden during the first month of the COVID-19 pandemic: (1) Life is normal in Sweden, (2) Sweden has a herd immunity strategy, (3) Sweden is not following expert advice, (4) Sweden is not following WHO recommendations (5) the Swedish approach is failing and (6) Swedes trust the government. While these narratives are partially grounded in reality, in some media outlets, the language and examples used to frame the story distorted the accuracy of the reporting.This debate examines the ways in which international media both constructs and represents a pandemic, and the implications for how researchers engage with news and social media. Cross-country comparison and the sharing of best practice are reliant on accurate information. The Swedish example underlines the importance of fact checking and source critique and the need for precision when presenting data and statistics. It also highlights limitations of using culture as an explanation for behavior, and the pitfalls of evaluating policy during a pandemic.", "doi": "10.1186/s12992-020-00588-x", "pmid": "32660503", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12992-020-00588-x"}, {"db": "pmc", "key": "PMC7356107"}], "notes": [], "created": "2020-12-08T10:44:40.041Z", "modified": "2020-12-08T10:44:40.049Z"}, {"entity": "publication", "iuid": "01e9b6b57731417a9927d1ad9f5d4027", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01e9b6b57731417a9927d1ad9f5d4027.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01e9b6b57731417a9927d1ad9f5d4027"}}, "title": "Effects of COVID-19 on Plastic Surgery Practices and Medi-Spas in Different Countries.", "authors": [{"family": "Montemurro", "given": "Paolo", "initials": "P"}, {"family": "Hed\u00e9n", "given": "Per", "initials": "P"}, {"family": "Adams", "given": "William P", "initials": "WP"}, {"family": "de Vita", "given": "Roy", "initials": "R"}, {"family": "Pellegatta", "given": "Tommaso", "initials": "T"}], "type": "letter", "published": "2020-07-13", "journal": {"title": "Aesthet Surg J", "issn": "1527-330X", "volume": "40", "issue": "8", "pages": "N453-N456", "issn-l": null}, "abstract": null, "doi": "10.1093/asj/sjaa104", "pmid": "32495819", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5851306"}, {"db": "pmc", "key": "PMC7314219"}], "notes": [], "created": "2020-12-09T10:48:40.042Z", "modified": "2020-12-09T10:48:40.065Z"}, {"entity": "publication", "iuid": "a1107310294e40e8886c613539a3151b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a1107310294e40e8886c613539a3151b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a1107310294e40e8886c613539a3151b"}}, "title": "The link between vitamin D and COVID-19: distinguishing facts from fiction.", "authors": [{"family": "Bergman", "given": "P", "initials": "P"}], "type": "editorial", "published": "2020-07-11", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1111/joim.13158", "pmid": "32652766", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7405052"}], "notes": [], "created": "2020-12-08T14:17:01.925Z", "modified": "2020-12-08T14:17:01.938Z"}, {"entity": "publication", "iuid": "0ffc406108044dabb325c6ff9858e0ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ffc406108044dabb325c6ff9858e0ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ffc406108044dabb325c6ff9858e0ae"}}, "title": "Psychometric Testing of Three COVID-19-Related Scales Among People with Mental Illness.", "authors": [{"family": "Chang", "given": "Kun-Chia", "initials": "KC"}, {"family": "Hou", "given": "Wen-Li", "initials": "WL"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}], "type": "journal article", "published": "2020-07-11", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "volume": null, "issue": null, "pages": "1-13", "issn-l": null}, "abstract": "Fear of novel coronavirus 2019 (COVID-19) may result in psychological health problems among different populations. Moreover, believing COVID-19 information and preventive COVID-19 infection behaviors are relevant constructs associated with fear of COVID-19. Therefore, the present study validated three instruments assessing fear, beliefs, and preventive behaviors related to COVID-19 among individuals with mental illness. Moreover, relationships between the three constructs were examined. Individuals with mental illness ( N = 400; 178 females; mean age = 46.91 years) completed the Fear of COVID-19 Scale (FCV-19S), Believing COVID-19 Information Scale (BCIS), Preventive COVID-19 Infection Behaviors Scale (PCIBS), and Depression Anxiety Stress Scale-21 (DASS-21). The FCV-19S, BCIS, and PCIBS demonstrated a single-factor structure with satisfactory fit indices. Moreover, believing COVID-19 information positively and significantly associated with fear of COVID-19, and fear of COVID-19 negatively and significantly associated with preventive behaviors and positively and significantly associated with psychological distress. The FCV-19S, BCIS, and PCIBS may assist healthcare providers in assessing COVID-19-related information among individuals with mental illness. Consequently, relevant programs may be designed to help individuals with mental illness going through the period of crisis.", "doi": "10.1007/s11469-020-00361-6", "pmid": "32837442", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "361"}, {"db": "pmc", "key": "PMC7354353"}], "notes": [], "created": "2020-12-07T10:34:46.665Z", "modified": "2021-02-26T08:45:47.848Z"}, {"entity": "publication", "iuid": "4d025e959931413b8de13ebe37146358", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4d025e959931413b8de13ebe37146358.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4d025e959931413b8de13ebe37146358"}}, "title": "Economic, Mental Health, HIV Prevention and HIV Treatment Impacts of COVID-19 and the COVID-19 Response on a Global Sample of Cisgender Gay Men and Other Men Who Have Sex with Men.", "authors": [{"family": "Santos", "given": "Glenn-Milo", "initials": "G"}, {"family": "Ackerman", "given": "Benjamin", "initials": "B"}, {"family": "Rao", "given": "Amrita", "initials": "A"}, {"family": "Wallach", "given": "Sara", "initials": "S"}, {"family": "Ayala", "given": "George", "initials": "G"}, {"family": "Lamontage", "given": "Erik", "initials": "E"}, {"family": "Garner", "given": "Alex", "initials": "A"}, {"family": "Holloway", "given": "Ian W", "initials": "IW"}, {"family": "Arreola", "given": "Sonya", "initials": "S"}, {"family": "Silenzio", "given": "Vince", "initials": "V"}, {"family": "Str\u00f6mdahl", "given": "Susanne", "initials": "S"}, {"family": "Yu", "given": "Louis", "initials": "L"}, {"family": "Strong", "given": "Carol", "initials": "C"}, {"family": "Adamson", "given": "Tyler", "initials": "T"}, {"family": "Yakusik", "given": "Anna", "initials": "A"}, {"family": "Doan", "given": "Tran Thu", "initials": "TT"}, {"family": "Huang", "given": "Poyao", "initials": "P"}, {"family": "Cerasuolo", "given": "Damiano", "initials": "D"}, {"family": "Bishop", "given": "Amie", "initials": "A"}, {"family": "Noori", "given": "Teymur", "initials": "T"}, {"family": "Pharris", "given": "Anastasia", "initials": "A"}, {"family": "Aung", "given": "Max", "initials": "M"}, {"family": "Dara", "given": "Masoud", "initials": "M"}, {"family": "Chung", "given": "Ssu Yu", "initials": "SY"}, {"family": "Hanley", "given": "Marguerite", "initials": "M"}, {"family": "Baral", "given": "Stefan", "initials": "S"}, {"family": "Beyrer", "given": "Chris", "initials": "C"}, {"family": "Howell", "given": "Sean", "initials": "S"}], "type": "journal article", "published": "2020-07-11", "journal": {"title": "AIDS Behav", "issn": "1573-3254", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "There is an urgent need to measure the impacts of COVID-19 among gay men and other men who have sex with men (MSM). We conducted a cross-sectional survey with a global sample of gay men and other MSM (n = 2732) from April 16, 2020 to May 4, 2020, through a social networking app. We characterized the economic, mental health, HIV prevention and HIV treatment impacts of COVID-19 and the COVID-19 response, and examined whether sub-groups of our study population are disproportionately impacted by COVID-19. Many gay men and other MSM not only reported economic and mental health consequences, but also interruptions to HIV prevention and testing, and HIV care and treatment services. These consequences were significantly greater among people living with HIV, racial/ethnic minorities, immigrants, sex workers, and socio-economically disadvantaged groups. These findings highlight the urgent need to mitigate the negative impacts of COVID-19 among gay men and other MSM.", "doi": "10.1007/s10461-020-02969-0", "pmid": "32654021", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10461-020-02969-0"}, {"db": "pmc", "key": "PMC7352092"}], "notes": [], "created": "2020-12-08T14:16:22.309Z", "modified": "2022-11-10T07:36:53.488Z"}, {"entity": "publication", "iuid": "b47287449a85462a81f301754bf0fea5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b47287449a85462a81f301754bf0fea5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b47287449a85462a81f301754bf0fea5"}}, "title": "Development and Validation of a Nomogram for Assessing Survival in Patients with COVID-19 Pneumonia.", "authors": [{"family": "Dong", "given": "Yi-Min", "initials": "YM"}, {"family": "Sun", "given": "Jia", "initials": "J"}, {"family": "Li", "given": "Yi-Xin", "initials": "YX"}, {"family": "Chen", "given": "Qian", "initials": "Q"}, {"family": "Liu", "given": "Qing-Quan", "initials": "QQ"}, {"family": "Sun", "given": "Zhou", "initials": "Z"}, {"family": "Pang", "given": "Ran", "initials": "R"}, {"family": "Chen", "given": "Fei", "initials": "F"}, {"family": "Xu", "given": "Bing-Yang", "initials": "BY"}, {"family": "Manyande", "given": "Anne", "initials": "A"}, {"family": "Clark", "given": "Taane G", "initials": "TG"}, {"family": "Li", "given": "Jin-Ping", "initials": "JP"}, {"family": "Orhan", "given": "Ilkay Erdogan", "initials": "IE"}, {"family": "Tian", "given": "Yu-Ke", "initials": "YK"}, {"family": "Wang", "given": "Tao", "initials": "T"}, {"family": "Wu", "given": "Wei", "initials": "W"}, {"family": "Ye", "given": "Da-Wei", "initials": "DW"}], "type": "journal article", "published": "2020-07-10", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "volume": null, "issue": null, "issn-l": "1058-4838"}, "abstract": "The outbreak of coronavirus disease (COVID-19) in 2019 has spread worldwide and continues to cause great threat to peoples' health as well as put pressure on the accessibility of medical systems. Early prediction of survival of hospitalized patients will help the clinical management of COVID-19, but such a prediction model which is reliable and valid is still lacking.\n\nWe retrospectively enrolled 628 confirmed cases of COVID-19 using positive RT-PCR tests for SARS-CoV-2 in Tongji Hospital in Wuhan, China. These patients were randomly grouped into a training cohort (60%) and a validation cohort (40%). In the training cohort, least absolute shrinkage and selection operator (LASSO) regression analysis and multivariate Cox regression analysis were utilized to identify prognostic factors for in-hospital survival of patients with COVID-19. A nomogram based on the three variables was built for clinical use. Areas under the ROC curves (AUC), concordance index (C-index) and calibration curve were used to evaluate the efficiency of the nomogram in both the training and validation cohorts.\n\nHypertension, higher neutrophil-to-lymphocyte ratio and increased NT-proBNP value were found to be significantly associated with poorer prognosis in hospitalized patients with COVID-19. The three predictors were further used to build a prediction nomogram. The C-index of the nomogram in the training and validation cohorts was 0.901 and 0.892, respectively. The AUC in the training cohort was 0.922 for 14- day and 0.919 for 21-day probability of in-hospital survival, while in the validation cohort was 0.922 and 0.881, respectively. Moreover, the calibration curve for 14- day and 21-day survival also showed high coherence between the predicted and actual probability of survival.\n\nWe managed to build a predictive model and constructed a nomogram for predicting in-hospital survival of patients with COVID-19. This model represents good performance and might be utilized clinically in the management of COVID-19.", "doi": "10.1093/cid/ciaa963", "pmid": "32649738", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "5869870"}, {"db": "pmc", "key": "PMC7454485"}], "notes": [], "created": "2020-11-19T14:39:34.744Z", "modified": "2021-02-26T08:46:13.460Z"}, {"entity": "publication", "iuid": "4038c04031e8472e973982d27d5b596c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4038c04031e8472e973982d27d5b596c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4038c04031e8472e973982d27d5b596c"}}, "title": "Trauma-informed responses in addressing public mental health consequences of the COVID-19 pandemic: position paper of the European Society for Traumatic Stress Studies (ESTSS).", "authors": [{"family": "Javakhishvili", "given": "Jana Darejan", "initials": "JD"}, {"family": "Ardino", "given": "Vittoria", "initials": "V"}, {"family": "Bragesj\u00f6", "given": "Maria", "initials": "M"}, {"family": "Kazlauskas", "given": "Evaldas", "initials": "E"}, {"family": "Olff", "given": "Miranda", "initials": "M"}, {"family": "Sch\u00e4fer", "given": "Ingo", "initials": "I"}], "type": "journal article", "published": "2020-07-09", "journal": {"title": "Eur J Psychotraumatol", "issn": "2000-8066", "volume": "11", "issue": "1", "pages": "1780782", "issn-l": null}, "abstract": "The COVID-19 pandemic has changed life in Europe and globally. The pandemic affects both individuals and the broader society across many domains, including physical and psychological health, the economy and general welfare. The measures taken to counteract the pandemic have significantly altered daily life and, along with the threat of contracting the coronavirus and uncertainties surrounding future developments, created a complex system of stressors with a negative impact on public mental health. This paper aims to outline the ESTSS strategy to address mental health issues related to COVID-19 and focuses on (1) trauma-informed policies, (2) capacity building, (3) collaborative research and (4) knowledge-exchange. To facilitate implementation of a trauma-informed approach and appropriate measures, ESTSS has developed a toolkit of recommendations on mental health and psychosocial assistance to be provided during the different phases of crisis and its aftermath. To promote capacity building, ESTSS offers a certification programme based on a curriculum in psychotraumatology and corresponding on-line training to the European community of mental health professionals. To assure evidence-based approaches and methods tailored to current circumstances, ESTSS has initiated a pan-European research project with international cooperation aimed at studying the mental health consequences of the pandemic, with a focus on psychological trauma and other stress-related reactions. To foster knowledge-exchange, the European Journal of Psychotraumatology (EJPT), the official journal of ESTSS, is publishing a special issue on COVID-19.", "doi": "10.1080/20008198.2020.1780782", "pmid": "33029320", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "1780782"}, {"db": "pmc", "key": "PMC7473312"}], "notes": [], "created": "2020-12-01T17:34:45.142Z", "modified": "2020-12-01T17:34:45.155Z"}, {"entity": "publication", "iuid": "a63ed59e45d94da1911ac1a678510612", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a63ed59e45d94da1911ac1a678510612.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a63ed59e45d94da1911ac1a678510612"}}, "title": "In the Name of COVID-19: Is the ECB Fuelling the Climate Crisis?", "authors": [{"family": "Cojoianu", "given": "T F", "initials": "TF"}, {"family": "Collins", "given": "E", "initials": "E"}, {"family": "Hoepner", "given": "A G F", "initials": "AGF"}, {"family": "Magill", "given": "D", "initials": "D"}, {"family": "O'Neill", "given": "T", "initials": "T"}, {"family": "Schneider", "given": "F I", "initials": "FI"}], "type": "journal article", "published": "2020-07-09", "journal": {"title": "Environ Resour Econ (Dordr)", "issn": "0924-6460", "volume": null, "issue": null, "pages": "1-7", "issn-l": null}, "abstract": "We offer preliminary evidence drawing on a novel dataset of corporate bonds issued in the European energy sector since January 2020 in combination with the European Central Bank's (ECB) purchases under the Pandemic Emergency Purchase Programme (PEPP) in response to COVID-19. We show that the likelihood of a European energy company bond to be bought as part of the ECB's programme increases with the greenhouse gas (GHG) intensity of the bond issuing firm. We also find weaker evidence that the ECB's PEPP portfolio during the pandemic is likely to become tilted towards companies with anti-climate lobbying activities and companies with less transparent GHG emissions disclosure. Our findings imply that, at later stages of the COVID-19 recovery, an in-depth analysis may be necessary to understand if, and if yes why, the ECB fuelled the climate crisis.", "doi": "10.1007/s10640-020-00450-z", "pmid": "32836830", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "450"}, {"db": "pmc", "key": "PMC7343577"}], "notes": [], "created": "2020-12-07T10:39:12.359Z", "modified": "2020-12-07T10:39:12.371Z"}, {"entity": "publication", "iuid": "68675153e8e349be9fbde1c8a97ed2a5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68675153e8e349be9fbde1c8a97ed2a5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68675153e8e349be9fbde1c8a97ed2a5"}}, "title": "How Medical Studies in Poland Prepare Future Healthcare Managers for Crises and Disasters: Results of a Pilot Study.", "authors": [{"family": "Misztal-Oko\u0144ska", "given": "Patrycja", "initials": "P"}, {"family": "Goniewicz", "given": "Krzysztof", "initials": "K"}, {"family": "Hertelendy", "given": "Attila J", "initials": "AJ"}, {"family": "Khorram-Manesh", "given": "Amir", "initials": "A"}, {"family": "Al-Wathinani", "given": "Ahmed", "initials": "A"}, {"family": "Alhazmi", "given": "Riyadh A", "initials": "RA"}, {"family": "Goniewicz", "given": "Mariusz", "initials": "M"}], "type": "journal article", "published": "2020-07-09", "journal": {"title": "Healthcare (Basel)", "issn": "2227-9032", "issn-l": null, "volume": "8", "issue": "3", "pages": null}, "abstract": "In the event of a crisis, rapid and effective assistance for victims is essential, and in many cases, medical assistance is required. To manage the situation efficiently, it is necessary to have a proactive management system in place that ensures professional assistance to victims and the safety of medical personnel. We evaluated the perceptions of students and graduates in public health studies at the Medical University of Lublin, Poland, concerning their preparation and management skills for crises such as the COVID-19 pandemic. This pilot study was conducted in March 2020; we employed an online survey with an anonymous questionnaire that was addressed to students and graduates with an educational focus in healthcare organization and management. The study involved 55 people, including 14 men and 41 women. Among the respondents, 41.8% currently worked in a healthcare facility and only 21.7% of them had participated in training related to preparation for emergencies and disasters in their current workplace. The respondents rated their workplaces' preparedness for the COVID-19 pandemic at four points. A significant number of respondents stated that if they had to manage a public health emergency, they would not be able to manage the situation correctly and not be able to predict its development. Managers of healthcare organizations should have the knowledge and skills to manage crises. It would be advisable for them to have been formally educated in public health or healthcare administration. In every healthcare facility, it is essential that training and practice of performing medical procedures in full personal protective equipment (PPE) be provided. Healthcare facilities must implement regular training combined with practical live scenario exercises to prepare for future crises.", "doi": "10.3390/healthcare8030202", "pmid": "32659897", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "healthcare8030202"}, {"db": "pmc", "key": "PMC7551878"}], "notes": [], "created": "2020-12-08T10:45:49.117Z", "modified": "2022-11-10T07:38:24.769Z"}, {"entity": "publication", "iuid": "6530aa23a91f405dab1dffe84e6082a7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6530aa23a91f405dab1dffe84e6082a7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6530aa23a91f405dab1dffe84e6082a7"}}, "title": "Female Faculty: Why So Few and Why Care?", "authors": [{"family": "Kamerlin", "given": "Shina Caroline Lynn", "initials": "SCL"}, {"family": "Wittung-Stafshede", "given": "Pernilla", "initials": "P"}], "type": "journal article", "published": "2020-07-08", "journal": {"title": "Chemistry", "issn": "1521-3765", "volume": "26", "issue": "38", "pages": "8319-8323", "issn-l": null}, "abstract": "Despite slow ongoing progress in increasing the representation of women in academia, women remain significantly under-represented at senior levels, in particular in the natural sciences and engineering. Not infrequently, this is downplayed by bringing forth arguments such as inherent biological differences between genders, that current policies are adequate to address the issue, or by deflecting this as being \"not my problem\" among other examples. In this piece we present scientific evidence that counters these claims, as well as a best-practice example, Genie, from Chalmers University of Technology, where one of the authors is currently employed. We also highlight particular challenges caused by the current COVID-19 pandemic. Finally, we conclude by proposing some possible solutions to the situation and emphasize that we need to all do our part, to ensure that the next generation of academics experience a more diverse, inclusive, and equitable working environment.", "doi": "10.1002/chem.202002522", "pmid": "32583921", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-08T15:52:50.109Z", "modified": "2020-12-08T15:52:50.134Z"}, {"entity": "publication", "iuid": "65e3364e9e5d4f9a8a2d4ff3daef5d7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65e3364e9e5d4f9a8a2d4ff3daef5d7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65e3364e9e5d4f9a8a2d4ff3daef5d7a"}}, "title": "Conspiracy Beliefs Are Associated with Lower Knowledge and Higher Anxiety Levels Regarding COVID-19 among Students at the University of Jordan.", "authors": [{"family": "Sallam", "given": "Malik", "initials": "M"}, {"family": "Dababseh", "given": "Deema", "initials": "D"}, {"family": "Yaseen", "given": "Alaa'", "initials": "A"}, {"family": "Al-Haidar", "given": "Ayat", "initials": "A"}, {"family": "Ababneh", "given": "Nidaa A", "initials": "NA"}, {"family": "Bakri", "given": "Faris G", "initials": "FG"}, {"family": "Mahafzah", "given": "Azmi", "initials": "A"}], "type": "journal article", "published": "2020-07-08", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "14", "pages": null}, "abstract": "The world has been afflicted heavily by the burden of coronavirus disease 2019 (COVID-19) that overwhelmed health care systems and caused severe economic and educational deficits, in addition to anxiety among the public. The main aim of this study was to evaluate the mutual effects of belief that the pandemic was the result of a conspiracy on knowledge and anxiety levels among students at the University of Jordan (UJ). An electronic-based survey was conducted between 29 March, 2020 and 31 March, 2020. The targeted population involved all undergraduate and postgraduate students from the health, scientific and humanities schools at UJ. Survey sections included 26 items on: socio-demographic information, knowledge and sources of information about the disease, attitude towards the false notion that COVID-19 stemmed from a conspiracy and items to assess the anxiety level among students during the quarantine period. The total number of participants was 1540 students. The mean age of study participants was 22 years and females predominated the study population (n = 1145, 74.4%). The majority of participants perceived the disease as moderately dangerous (n = 1079, 70.1%). Males, Jordanians and participants with lower income were more inclined to feel that COVID-19 is very dangerous. A lower level of knowledge and a higher level of anxiety about COVID-19 were associated with the belief that the disease is part of a conspiracy. Females and participants with lower income were more likely to believe that the disease is related to conspiracy. Belief in conspiracy regarding the origin of COVID-19 was associated with misinformation about the availability of a vaccine and the therapeutic use of antibiotics for COVID-19 treatment. The Ministry of Health in Jordan was the most common source of information about COVID-19 reported by the participants (n = 1018). The false belief that COVID-19 was the result of a global conspiracy could be the consequence of a lower level of knowledge about the virus and could lead to a higher level of anxiety, which should be considered in the awareness tools of various media platforms about the current pandemic.", "doi": "10.3390/ijerph17144915", "pmid": "32650409", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "ijerph17144915"}, {"db": "pmc", "key": "PMC7399915"}], "notes": [], "created": "2020-12-08T14:17:45.329Z", "modified": "2022-11-10T07:40:15.463Z"}, {"entity": "publication", "iuid": "fb4d376b71a345b9aff49daecbc61a83", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb4d376b71a345b9aff49daecbc61a83.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb4d376b71a345b9aff49daecbc61a83"}}, "title": "Combination treatments with hydroxychloroquine and azithromycin are compatible with the therapeutic induction of anticancer immune responses.", "authors": [{"family": "Liu", "given": "Peng", "initials": "P"}, {"family": "Zhao", "given": "Liwei", "initials": "L"}, {"family": "Ferrere", "given": "Gladys", "initials": "G"}, {"family": "Alves-Costa-Silva", "given": "Carolina", "initials": "C"}, {"family": "Ly", "given": "Pierre", "initials": "P"}, {"family": "Wu", "given": "Qi", "initials": "Q"}, {"family": "Tian", "given": "Ai-Ling", "initials": "AL"}, {"family": "Derosa", "given": "Lisa", "initials": "L"}, {"family": "Zitvogel", "given": "Laurence", "initials": "L"}, {"family": "Kepp", "given": "Oliver", "initials": "O"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}], "type": "journal article", "published": "2020-07-08", "journal": {"title": "Oncoimmunology", "issn": "2162-4011", "volume": "9", "issue": "1", "pages": "1789284", "issn-l": null}, "abstract": "Amid controversial reports that COVID-19 can be treated with a combination of the antimalarial drug hydroxychloroquine (HCQ) and the antibiotic azithromycin (AZI), a clinical trial (ONCOCOVID, NCT04341207) was launched at Gustave Roussy Cancer Campus to investigate the utility of this combination therapy in cancer patients. In this preclinical study, we investigated whether the combination of HCQ+AZI would be compatible with the therapeutic induction of anticancer immune responses. For this, we used doses of HCQ and AZI that affect whole-body physiology (as indicated by a partial blockade in cardiac and hepatic autophagic flux for HCQ and a reduction in body weight for AZI), showing that their combined administration did not interfere with tumor growth control induced by the immunogenic cell death inducer oxaliplatin. Moreover, the HCQ+AZI combination did not affect the capacity of a curative regimen (cisplatin + crizotinib + PD-1 blockade) to eradicate established orthotopic lung cancers in mice. In conclusion, it appears that HCQ+AZI does not interfere with the therapeutic induction of therapeutic anticancer immune responses.", "doi": "10.1080/2162402X.2020.1789284", "pmid": "32923151", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "1789284"}, {"db": "pmc", "key": "PMC7458592"}], "notes": [], "created": "2020-12-03T15:36:32.115Z", "modified": "2021-02-26T08:45:03.362Z"}, {"entity": "publication", "iuid": "846ec4f0a2d84dc681ee8697ff6ea46c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/846ec4f0a2d84dc681ee8697ff6ea46c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/846ec4f0a2d84dc681ee8697ff6ea46c"}}, "title": "Wastewater-Based Epidemiology: Global Collaborative to Maximize Contributions in the Fight Against COVID-19.", "authors": [{"family": "Bivins", "given": "Aaron", "initials": "A"}, {"family": "North", "given": "Devin", "initials": "D"}, {"family": "Ahmad", "given": "Arslan", "initials": "A"}, {"family": "Ahmed", "given": "Warish", "initials": "W"}, {"family": "Alm", "given": "Eric", "initials": "E"}, {"family": "Been", "given": "Frederic", "initials": "F"}, {"family": "Bhattacharya", "given": "Prosun", "initials": "P"}, {"family": "Bijlsma", "given": "Lubertus", "initials": "L"}, {"family": "Boehm", "given": "Alexandria B", "initials": "AB"}, {"family": "Brown", "given": "Joe", "initials": "J"}, {"family": "Buttiglieri", "given": "Gianluigi", "initials": "G"}, {"family": "Calabro", "given": "Vincenza", "initials": "V"}, {"family": "Carducci", "given": "Annalaura", "initials": "A"}, {"family": "Castiglioni", "given": "Sara", "initials": "S"}, {"family": "Cetecioglu Gurol", "given": "Zeynep", "initials": "Z"}, {"family": "Chakraborty", "given": "Sudip", "initials": "S"}, {"family": "Costa", "given": "Federico", "initials": "F"}, {"family": "Curcio", "given": "Stefano", "initials": "S"}, {"family": "de Los Reyes", "given": "Francis L", "initials": "FL"}, {"family": "Delgado Vela", "given": "Jeseth", "initials": "J"}, {"family": "Farkas", "given": "Kata", "initials": "K"}, {"family": "Fernandez-Casi", "given": "Xavier", "initials": "X"}, {"family": "Gerba", "given": "Charles", "initials": "C"}, {"family": "Gerrity", "given": "Daniel", "initials": "D"}, {"family": "Girones", "given": "Rosina", "initials": "R"}, {"family": "Gonzalez", "given": "Raul", "initials": "R"}, {"family": "Haramoto", "given": "Eiji", "initials": "E"}, {"family": "Harris", "given": "Angela", "initials": "A"}, {"family": "Holden", "given": "Patricia A", "initials": "PA"}, {"family": "Islam", "given": "Md Tahmidul", "initials": "MT"}, {"family": "Jones", "given": "Davey L", "initials": "DL"}, {"family": "Kasprzyk-Hordern", "given": "Barbara", "initials": "B"}, {"family": "Kitajima", "given": "Masaaki", "initials": "M"}, {"family": "Kotlarz", "given": "Nadine", "initials": "N"}, {"family": "Kumar", "given": "Manish", "initials": "M"}, {"family": "Kuroda", "given": "Keisuke", "initials": "K"}, {"family": "La Rosa", "given": "Giuseppina", "initials": "G"}, {"family": "Malpei", "given": "Francesca", "initials": "F"}, {"family": "Mautus", "given": "Mariana", "initials": "M"}, {"family": "McLellan", "given": "Sandra L", "initials": "SL"}, {"family": "Medema", "given": "Gertjan", "initials": "G"}, {"family": "Meschke", "given": "John Scott", "initials": "JS"}, {"family": "Mueller", "given": "Jochen", "initials": "J"}, {"family": "Newton", "given": "Ryan J", "initials": "RJ"}, {"family": "Nilsson", "given": "David", "initials": "D"}, {"family": "Noble", "given": "Rachel T", "initials": "RT"}, {"family": "van Nuijs", "given": "Alexander", "initials": "A"}, {"family": "Peccia", "given": "Jordan", "initials": "J"}, {"family": "Perkins", "given": "T Alex", "initials": "TA"}, {"family": "Pickering", "given": "Amy J", "initials": "AJ"}, {"family": "Rose", "given": "Joan", "initials": "J"}, {"family": "Sanchez", "given": "Gloria", "initials": "G"}, {"family": "Smith", "given": "Adam", "initials": "A"}, {"family": "Stadler", "given": "Lauren", "initials": "L"}, {"family": "Stauber", "given": "Christine", "initials": "C"}, {"family": "Thomas", "given": "Kevin", "initials": "K"}, {"family": "van der Voorn", "given": "Tom", "initials": "T"}, {"family": "Wigginton", "given": "Krista", "initials": "K"}, {"family": "Zhu", "given": "Kevin", "initials": "K"}, {"family": "Bibby", "given": "Kyle", "initials": "K"}], "type": "news", "published": "2020-07-07", "journal": {"title": "Environ Sci Technol", "issn": "1520-5851", "volume": "54", "issue": "13", "pages": "7754-7757", "issn-l": null}, "abstract": null, "doi": "10.1021/acs.est.0c02388", "pmid": "32530639", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7299382"}], "notes": [], "created": "2020-12-09T10:05:39.307Z", "modified": "2020-12-09T10:05:39.328Z"}, {"entity": "publication", "iuid": "6e381cbd252b437fa63080f76d62df4c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e381cbd252b437fa63080f76d62df4c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e381cbd252b437fa63080f76d62df4c"}}, "title": "Relationship Between Odor Intensity Estimates and COVID-19 Prevalence Prediction in a Swedish Population", "authors": [{"family": "Iravani", "given": "Behzad", "initials": "B", "orcid": "0000-0001-9905-1067", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5c799aeccef49a59531ad96984f466b.json"}}, {"family": "Arshamian", "given": "Artin", "initials": "A"}, {"family": "Ravia", "given": "Aharon", "initials": "A"}, {"family": "Mishor", "given": "Eva", "initials": "E"}, {"family": "Snitz", "given": "Kobi", "initials": "K"}, {"family": "Shushan", "given": "Sagit", "initials": "S"}, {"family": "Roth", "given": "Yehudah", "initials": "Y"}, {"family": "Perl", "given": "Ofer", "initials": "O"}, {"family": "Honigstein", "given": "Danielle", "initials": "D"}, {"family": "Weissgross", "given": "Reut", "initials": "R"}, {"family": "Karagach", "given": "Shiri", "initials": "S"}, {"family": "Ernst", "given": "Gernot", "initials": "G"}, {"family": "Okamoto", "given": "Masako", "initials": "M"}, {"family": "Mainen", "given": "Zachary", "initials": "Z"}, {"family": "Monteleone", "given": "Erminio", "initials": "E"}, {"family": "Dinnella", "given": "Caterina", "initials": "C"}, {"family": "Spinelli", "given": "Sara", "initials": "S"}, {"family": "Mari\u00f1o-S\u00e1nchez", "given": "Franklin", "initials": "F"}, {"family": "Ferdenzi", "given": "Camille", "initials": "C"}, {"family": "Smeets", "given": "Monique", "initials": "M"}, {"family": "Touhara", "given": "Kazushige", "initials": "K"}, {"family": "Bensafi", "given": "Moustafa", "initials": "M", "orcid": "0000-0002-2991-3036", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/11b9f8b4dfbd4345ad03a0a694d5efcd.json"}}, {"family": "Hummel", "given": "Thomas", "initials": "T", "orcid": "0000-0001-9713-0183", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/271198f0dc1f4b3fa9bef3d1225a24bf.json"}}, {"family": "Sobel", "given": "Noam", "initials": "N"}, {"family": "Lundstr\u00f6m", "given": "Johan N", "initials": "JN", "orcid": "0000-0002-3529-8981", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3a92f50aea024a1fbf0cfda979efef11.json"}}], "type": "journal-article", "published": "2020-07-07", "journal": {"title": "Chem Senses", "issn": "0379-864X", "volume": "45", "issue": "6", "pages": "449-456", "issn-l": null}, "abstract": "In response to the COVID-19 pandemic, countries have implemented various strategies to reduce and slow the spread of the disease in the general population. For countries that have implemented restrictions on its population in a step-wise manner, monitoring of COVID-19 prevalence is of importance to guide decision on when to impose new, or when to abolish old, restrictions. We are here determining whether measures of odor intensity in a large sample can serve as one such measure. Online measures of how intense common household odors are perceived and symptoms of COVID-19 were collected from 2440 Swedes. Average odor intensity ratings were then compared to predicted COVID-19 population prevalence over time in the Swedish population and were found to closely track each other (r=-0.83). Moreover, we found that there was a large difference in rated intensity between individuals with and without COVID-19 symptoms and number of symptoms was related to odor intensity ratings. Finally, we found that individuals progressing from reporting no symptoms to subsequently reporting COVID-19 symptoms demonstrated a large drop in olfactory performance. These data suggest that measures of odor intensity, if obtained in a large and representative sample, can be used as an indicator of COVID-19 disease in the general population. Importantly, this simple measure could easily be implemented in countries without widespread access to COVID-19 testing or implemented as a fast early response before wide-spread testing can be facilitated.", "doi": "10.1093/chemse/bjaa034", "pmid": "32441744", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "5842049"}, {"db": "pmc", "key": "PMC7314115"}], "notes": [], "created": "2020-11-25T09:11:13.432Z", "modified": "2021-12-06T13:17:58.519Z"}, {"entity": "publication", "iuid": "46bea90f079749b5acc9ceed9a2570f9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/46bea90f079749b5acc9ceed9a2570f9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/46bea90f079749b5acc9ceed9a2570f9"}}, "title": "Has Venoarterial ECMO Been Underutilized in COVID-19 Patients?", "authors": [{"family": "De Piero", "given": "Maria Elena", "initials": "ME"}, {"family": "Lo Coco", "given": "Valeria", "initials": "V"}, {"family": "Taccone", "given": "Fabio Silvio", "initials": "FS"}, {"family": "Belliato", "given": "Mirko", "initials": "M"}, {"family": "Broman", "given": "Lars M", "initials": "LM"}, {"family": "Malfertheiner", "given": "Maximilian V", "initials": "MV"}, {"family": "Lorusso", "given": "Roberto", "initials": "R"}], "type": "editorial", "published": "2020-07-07", "journal": {"title": "Innovations (Phila)", "issn": "1559-0879", "volume": "15", "issue": "4", "pages": "317-321", "issn-l": null}, "abstract": null, "doi": "10.1177/1556984520939076", "pmid": "32634058", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-08T14:36:09.388Z", "modified": "2020-12-08T14:36:09.411Z"}, {"entity": "publication", "iuid": "0ad3e7bd357b483e955e3a096d969e77", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ad3e7bd357b483e955e3a096d969e77.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ad3e7bd357b483e955e3a096d969e77"}}, "title": "European consensus recommendations for neonatal and paediatric retrievals of positive or suspected COVID-19 patients.", "authors": [{"family": "Terheggen", "given": "Ulrich", "initials": "U"}, {"family": "Heiring", "given": "Christian", "initials": "C"}, {"family": "Kjellberg", "given": "Mattias", "initials": "M"}, {"family": "Hegardt", "given": "Fredrik", "initials": "F"}, {"family": "Kneyber", "given": "Martin", "initials": "M"}, {"family": "Gente", "given": "Maurizio", "initials": "M"}, {"family": "Roehr", "given": "Charles C", "initials": "CC"}, {"family": "Jourdain", "given": "Gilles", "initials": "G"}, {"family": "Tissieres", "given": "Pierre", "initials": "P"}, {"family": "Ramnarayan", "given": "Padmanabhan", "initials": "P"}, {"family": "Breindahl", "given": "Morten", "initials": "M"}, {"family": "van den Berg", "given": "Johannes", "initials": "J"}], "type": "journal article", "published": "2020-07-07", "journal": {"title": "Pediatr Res", "issn": "1530-0447", "volume": null, "issue": null, "pages": null, "issn-l": "0031-3998"}, "abstract": "The 2020 novel coronavirus (SARS-Cov-2) pandemic necessitates tailored recommendations addressing specific procedures for neonatal and paediatric transport of suspected or positive COVID-19 patients. The aim of this consensus statement is to define guidelines for safe clinical care for children needing inter-facility transport while making sure that the clinical teams involved are sufficiently protected from SARS-CoV-2.\r\n\r\nA taskforce, composed of members of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC) Transport section and the European Society for Paediatric Research (ESPR), reviewed the published literature and used a rapid, two-step modified Delphi process to formulate recommendations regarding safety and clinical management during transport of COVID-19 patients.\r\n\r\nThe joint taskforce consisted of a panel of 12 experts who reached an agreement on a set of 17 recommendations specifying pertinent aspects on neonatal and paediatric COVID-19 patient transport. These included: case definition, personal protective equipment, airway management, equipment and strategies for invasive and non-invasive ventilation, special considerations for incubator and open stretcher transports, parents on transport and decontamination of transport vehicles.\r\n\r\nOur consensus recommendations aim to define current best-practice and should help guide transport teams dealing with infants and children with COVID-19 to work safely and effectively.\r\n\r\nWe present European consensus recommendations on pertinent measures for transporting infants and children in times of the coronavirus (SARS-Cov-2 /COVID-19) pandemic.A panel of experts reviewed the evidence around transporting infants and children with proven or suspected COVID-19. Specific guidance on aspects of personal protective equipment, airway management and considerations for incubator and open stretcher transports is presented.Based on scant evidence, best-practice recommendations for neonatal and paediatric transport teams are presented, aiming for the protection of teams and patients. We highlight gaps in knowledge and areas of future research.", "doi": "10.1038/s41390-020-1050-z", "pmid": "32634819", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41390-020-1050-z"}], "notes": [], "created": "2020-11-19T14:31:03.050Z", "modified": "2020-11-30T08:51:26.698Z"}, {"entity": "publication", "iuid": "9f4418e203d646a3aea9f4da8d915c56", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9f4418e203d646a3aea9f4da8d915c56.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9f4418e203d646a3aea9f4da8d915c56"}}, "title": "Complete protection from covid-19 is possible for health workers.", "authors": [{"family": "Karlsson", "given": "Ulf", "initials": "U"}, {"family": "Fraenkel", "given": "Carl-Johan", "initials": "CJ"}], "type": "editorial", "published": "2020-07-07", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "370", "issue": null, "pages": "m2641", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m2641", "pmid": "32636186", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-08T14:30:49.116Z", "modified": "2020-12-08T14:30:49.127Z"}, {"entity": "publication", "iuid": "f9d8dc3406334b78bbea45064cff29ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f9d8dc3406334b78bbea45064cff29ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f9d8dc3406334b78bbea45064cff29ee"}}, "title": "[The virtual ward - the students' clinical education during the current pandemic].", "authors": [{"family": "Robertson", "given": "Josefina", "initials": "J"}, {"family": "Ahlgren", "given": "Erika", "initials": "E"}, {"family": "Rydberg", "given": "Frida", "initials": "F"}, {"family": "Snygg-Martin", "given": "Ulrika", "initials": "U"}, {"family": "Westin", "given": "Johan", "initials": "J"}, {"family": "Studahl", "given": "Marie", "initials": "M"}], "type": "journal article", "published": "2020-07-06", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "volume": "117", "issue": null, "issn-l": "0023-7205"}, "abstract": "On March 17, 2020, the Swedish Government recommended all higher education institutions to move to online and distance learning during the COVID-19 pandemic. The integrated course in Infection, Microbiology, and Immunity at the Programme in Medicine at University of Gothenburg had to be completely transformed. Creative solutions have now replaced the clinical training that normally takes place during the students' clinical education at the hospital. We developed a digital concept entitled \"the virtual ward\", in which we interact with the students in real time. Here, the students are able to follow their patients on a daily basis during teacher-guided sessions.", "doi": null, "pmid": "32633809", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "20077"}], "notes": [], "created": "2020-12-08T14:39:33.360Z", "modified": "2020-12-08T14:39:33.372Z"}, {"entity": "publication", "iuid": "8b1c4e0ddc2441c08331bc2a0429303d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8b1c4e0ddc2441c08331bc2a0429303d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8b1c4e0ddc2441c08331bc2a0429303d"}}, "title": "Why policy action should focus on the vulnerable commercial sex workers in Uganda during COVID-19 fight.", "authors": [{"family": "Kawala", "given": "Brenda Allen", "initials": "BA"}, {"family": "Kirui", "given": "Brian Kibiwott", "initials": "BK"}, {"family": "Cumber", "given": "Samuel Nambile", "initials": "SN"}], "type": "letter", "published": "2020-07-06", "journal": {"title": "Pan Afr Med J", "issn": "1937-8688", "volume": "35", "issue": "Suppl 2", "pages": "102", "issn-l": null}, "abstract": null, "doi": "10.11604/pamj.supp.2020.35.2.24664", "pmid": "33282057", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "PAMJ-SUPP-35-2-102"}, {"db": "pmc", "key": "PMC7687465"}], "notes": [], "created": "2020-12-10T09:18:47.080Z", "modified": "2020-12-10T09:18:47.091Z"}, {"entity": "publication", "iuid": "7207513ff7874785b676fa1a4be24ddb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7207513ff7874785b676fa1a4be24ddb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7207513ff7874785b676fa1a4be24ddb"}}, "title": "Anti-coagulation for COVID-19 treatment: both anti-thrombotic and anti-inflammatory?", "authors": [{"family": "Paar", "given": "Vera", "initials": "V"}, {"family": "Wernly", "given": "Bernhard", "initials": "B"}, {"family": "Zhou", "given": "Zhichao", "initials": "Z"}, {"family": "Motloch", "given": "Lukas J", "initials": "LJ"}, {"family": "Hoppe", "given": "Uta C", "initials": "UC"}, {"family": "Egle", "given": "Alexander", "initials": "A"}, {"family": "Lichtenauer", "given": "Michael", "initials": "M"}], "type": "journal article", "published": "2020-07-06", "journal": {"title": "J Thromb Thrombolysis", "issn": "1573-742X", "volume": null, "issue": null, "issn-l": null}, "abstract": "Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has been linked to a higher risk of mortality compared to influenza, which is mainly due to severe secondary diseases, such as acute respiratory distress syndrome (ARDS). In turn, ARDS is characterized by an acute inflammation and an excessive activity of the coagulation cascade, rising the vulnerability for venous thromboembolic events. In order to investigate the relation of inflammation and the influence of coagulation factors on their release, human peripheral mononuclear blood cells (PBMCs) were treated with autologous serum, heparinized plasma and different doses of fibrin. Thereafter, the concentration of pro-inflammatory cytokines and chemokines in the secretome of PBMCs was measured by enzyme-linked immunosorbent assay. Our analyses revealed autologous serum to significantly increase the secretion of cytokines and chemokines after 24 h of incubation time. Furthermore, the addition of fibrin markedly increased the secretion of cytokines and chemokines by PBMCs in a dose-dependent manner. Consequently, in accordance with previous studies, our study outlines that anti-coagulation may constitute a promising tool for the treatment of SARS-CoV-2, reducing both, the cytokine storm, as well as the risk for thrombotic complications.", "doi": "10.1007/s11239-020-02212-6", "pmid": "32632558", "labels": {"Type: Journal article": null, "Category: Biochemistry": null}, "xrefs": [{"db": "pii", "key": "10.1007/s11239-020-02212-6"}, {"db": "pmc", "key": "PMC7338133"}], "notes": [], "created": "2020-12-08T14:40:18.189Z", "modified": "2021-02-26T08:45:03.055Z"}, {"entity": "publication", "iuid": "ab46cb3b389f498e9f66c700d13ce759", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ab46cb3b389f498e9f66c700d13ce759.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ab46cb3b389f498e9f66c700d13ce759"}}, "title": "A Silent Infection Pandemic of COVID-19: Epidemiological Investigation and Hypothetical Models.", "authors": [{"family": "Geng", "given": "Jianping", "initials": "J"}, {"family": "Yu", "given": "Jun", "initials": "J", "orcid": "0000-0003-2006-758X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/30dd1b66e1284ab1aa3566ab21556595.json"}}, {"family": "Lu", "given": "Tao", "initials": "T"}, {"family": "Wang", "given": "Yinhe", "initials": "Y"}, {"family": "Cao", "given": "Yang", "initials": "Y", "orcid": "0000-0002-3552-9153", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7594ca0fdf2d4f238ca04a788a405cdb.json"}}], "type": "journal article", "published": "2020-07-05", "journal": {"title": "Can J Infect Dis Med Microbiol", "issn": "1712-9532", "volume": "2020", "issue": null, "pages": "5120253", "issn-l": null}, "abstract": "To explore the epidemic mode of COVID-19, we made an epidemiological investigation, set up hypothetical models, and compared them with hepatitis A virus (HAV) age-specific epidemic characteristic. In the epidemiological investigation, we reported the first familial COVID-19 silent infection in the world. A 19-year-old healthy female COVID-19 virus carrier without any symptoms caused two mild and one severe pneumonia. In hypothetical models, the silent infection rate ranges from 60% to 80% based on 3 sources: China mainland, evacuation of 4 nationals, and the ship \"Diamond Princess,\" respectively. In comparison with HAV, COVID-19 shows the same infection mode in children (aged 0-9 years), but significant difference in young adults (aged 10-44 years) and the elderly (aged 45 years or older). Therefore, we prejudged that COVID-19 is a silent infection pandemic mainly in young adults but threatens the elderly.", "doi": "10.1155/2020/5120253", "pmid": "32670439", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7341389"}], "notes": [], "created": "2020-12-07T16:37:05.988Z", "modified": "2023-06-19T14:36:40.335Z"}, {"entity": "publication", "iuid": "9c6f1f68c72547ee948469c8d27d2ff3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9c6f1f68c72547ee948469c8d27d2ff3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9c6f1f68c72547ee948469c8d27d2ff3"}}, "title": "Rapid Detection of COVID-19 Coronavirus Using a Reverse Transcriptional Loop-Mediated Isothermal Amplification (RT-LAMP) Diagnostic Platform", "authors": [{"family": "Yu", "given": "Lin", "initials": "L"}, {"family": "Wu", "given": "Shanshan", "initials": "S"}, {"family": "Hao", "given": "Xiaowen", "initials": "X"}, {"family": "Dong", "given": "Xue", "initials": "X"}, {"family": "Mao", "given": "Lingling", "initials": "L"}, {"family": "Pelechano", "given": "Vicent", "initials": "V"}, {"family": "Chen", "given": "Wei Hua", "initials": "WH"}, {"family": "Yin", "given": "Xiushan", "initials": "X"}], "type": "journal-article", "published": "2020-07-01", "journal": {"title": "Clin Chem", "issn": "0009-9147", "issn-l": null, "volume": "66", "issue": "7", "pages": "975-977"}, "abstract": null, "doi": "10.1093/clinchem/hvaa102", "pmid": "32315390", "labels": {"Funder: KAW/SciLifeLab": null, "Type: Journal article": null, "Research Area: Diagnostics for virus": null, "Funder: VR": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "5823294"}, {"db": "pmc", "key": "PMC7188121"}], "notes": [], "created": "2020-11-04T07:17:58.514Z", "modified": "2022-02-14T06:39:01.697Z"}, {"entity": "publication", "iuid": "7c12e4c6f6564264835fcdd9ee827c45", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7c12e4c6f6564264835fcdd9ee827c45.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7c12e4c6f6564264835fcdd9ee827c45"}}, "title": "Managing COVID-19 spread with voluntary public-health measures: Sweden as a case study for pandemic control.", "authors": [{"family": "Kamerlin", "given": "Shina C L", "initials": "SCL"}, {"family": "Kasson", "given": "Peter M", "initials": "PM"}], "type": "journal article", "published": "2020-07-01", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "issn-l": "1058-4838", "volume": null, "issue": null, "pages": null}, "abstract": "The COVID-19 pandemic has spread globally, causing extensive illness and mortality. In advance of effective antiviral therapies, countries have applied different public-health strategies to control spread and manage healthcare need. Sweden has taken a unique approach of not implementing strict closures, instead urging personal responsibility. We analyze the results of this and other potential strategies for pandemic control in Sweden.\r\n\r\nWe implemented individual-based modeling of COVID-19 spread in Sweden using population, employment, and household data. Epidemiological parameters for COVID-19 were validated on a limited date range; where substantial uncertainties remained, multiple parameters were tested. The effects of different public-health strategies were tested over a 160-day period, analyzed for their effects on ICU demand and death rate, and compared to Swedish data for April 2020.\r\n\r\nSwedish mortality rates fall intermediate between European countries that quickly imposed stringent public-health controls and countries that acted later. Models most closely reproducing reported mortality data suggest large portions of the population voluntarily self-isolate. Swedish ICU utilization rates remained lower than predicted, but a large fraction of deaths occurred in non-ICU patients. This suggests that patient prognosis was considered in ICU admission, reducing healthcare load at a cost of decreased survival in patients not admitted.\r\n\r\nThe Swedish COVID-19 strategy has thus far yielded a striking result: mild mandates overlaid with voluntary measures can achieve results highly similar to late-onset stringent mandates. However, this policy causes more healthcare demand and mortality than early stringent control and depends on continued public will.", "doi": "10.1093/cid/ciaa864", "pmid": "32609825", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "5866094"}, {"db": "pmc", "key": "PMC7337695"}], "notes": [], "created": "2020-12-08T15:22:07.519Z", "modified": "2022-11-10T07:46:04.133Z"}, {"entity": "publication", "iuid": "541e95e5a6334de69e1c372342eaaf59", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/541e95e5a6334de69e1c372342eaaf59.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/541e95e5a6334de69e1c372342eaaf59"}}, "title": "Utilitarianism and the pandemic.", "authors": [{"family": "Savulescu", "given": "Julian", "initials": "J"}, {"family": "Persson", "given": "Ingmar", "initials": "I"}, {"family": "Wilkinson", "given": "Dominic", "initials": "D"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Bioethics", "issn": "1467-8519", "volume": "34", "issue": "6", "pages": "620-632", "issn-l": null}, "abstract": "There are no egalitarians in a pandemic. The scale of the challenge for health systems and public policy means that there is an ineluctable need to prioritize the needs of the many. It is impossible to treat all citizens equally, and a failure to carefully consider the consequences of actions could lead to massive preventable loss of life. In a pandemic there is a strong ethical need to consider how to do most good overall. Utilitarianism is an influential moral theory that states that the right action is the action that is expected to produce the greatest good. It offers clear operationalizable principles. In this paper we provide a summary of how utilitarianism could inform two challenging questions that have been important in the early phase of the pandemic: (a) Triage: which patients should receive access to a ventilator if there is overwhelming demand outstripping supply? (b) Lockdown: how should countries decide when to implement stringent social restrictions, balancing preventing deaths from COVID-19 with causing deaths and reductions in well-being from other causes? Our aim is not to argue that utilitarianism is the only relevant ethical theory, or in favour of a purely utilitarian approach. However, clearly considering which options will do the most good overall will help societies identify and consider the necessary cost of other values. Societies may choose either to embrace or not to embrace the utilitarian course, but with a clear understanding of the values involved and the price they are willing to pay.", "doi": "10.1111/bioe.12771", "pmid": "32433782", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7276855"}], "notes": [], "created": "2020-12-09T11:36:17.611Z", "modified": "2020-12-09T11:36:17.636Z"}, {"entity": "publication", "iuid": "a43e85c7b8bd42f98fbfd6c4a67d3a83", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a43e85c7b8bd42f98fbfd6c4a67d3a83.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a43e85c7b8bd42f98fbfd6c4a67d3a83"}}, "title": "Uncovering the Devaluation of Nursing Home Staff During COVID-19: Are We Fuelling the Next Health Care Crisis?", "authors": [{"family": "McGilton", "given": "Katherine S", "initials": "KS"}, {"family": "Escrig-Pinol", "given": "Astrid", "initials": "A"}, {"family": "Gordon", "given": "Adam", "initials": "A"}, {"family": "Chu", "given": "Charlene H", "initials": "CH"}, {"family": "Z\u00fa\u00f1iga", "given": "Franziska", "initials": "F"}, {"family": "Sanchez", "given": "Montserrat Gea", "initials": "MG"}, {"family": "Boscart", "given": "Veronique", "initials": "V"}, {"family": "Meyer", "given": "Julienne", "initials": "J"}, {"family": "Corazzini", "given": "Kirsten N", "initials": "KN"}, {"family": "Jacinto", "given": "Alessandro Ferrari", "initials": "AF"}, {"family": "Spilsbury", "given": "Karen", "initials": "K"}, {"family": "Backman", "given": "Annica", "initials": "A"}, {"family": "Scales", "given": "Kezia", "initials": "K"}, {"family": "Fagertun", "given": "Anette", "initials": "A"}, {"family": "Wu", "given": "Bei", "initials": "B"}, {"family": "Edvardsson", "given": "David", "initials": "D"}, {"family": "Lepore", "given": "Michael J", "initials": "MJ"}, {"family": "Leung", "given": "Angela Y M", "initials": "AYM"}, {"family": "Siegel", "given": "Elena O", "initials": "EO"}, {"family": "Noguchi-Watanabe", "given": "Maiko", "initials": "M"}, {"family": "Wang", "given": "Jing", "initials": "J"}, {"family": "Bowers", "given": "Barbara", "initials": "B"}], "type": "editorial", "published": "2020-07-00", "journal": {"title": "J Am Med Dir Assoc", "issn": "1538-9375", "volume": "21", "issue": "7", "pages": "962-965", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jamda.2020.06.010", "pmid": "32674829", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1525-8610(20)30492-8"}, {"db": "pmc", "key": "PMC7287421"}], "notes": [], "created": "2020-12-07T16:36:02.866Z", "modified": "2020-12-07T16:36:02.876Z"}, {"entity": "publication", "iuid": "280d2226abe54b8989ec40218181f134", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/280d2226abe54b8989ec40218181f134.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/280d2226abe54b8989ec40218181f134"}}, "title": "Unconventional Answers to Unprecedented Challenges: The Swedish Experience During the COVID-19 Outbreak.", "authors": [{"family": "Valeriani", "given": "Giuseppe", "initials": "G"}, {"family": "Vukovic", "given": "Iris Sarajlic", "initials": "IS"}, {"family": "Mollica", "given": "Richard", "initials": "R"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "J Prev Med Public Health", "issn": "2233-4521", "volume": "53", "issue": "4", "pages": "233-235", "issn-l": null}, "abstract": "Since its early stages, the coronavirus disease 2019 (COVID-19) pandemic has posed immense challenges in meeting the public health and healthcare and social care needs of migrants. In line with other reports from United Kingdom and United States, data from Sweden's health authority show that migrants have been disproportionately affected by COVID-19. Following the World Health Organization's statements, as well as the European Public Health Association's call for action, several centres in Sweden's most populated areas have activated tools to implement national plans for community outreach through initiatives targeting migrants and ethnic minority groups. Unconventional means should be promoted to mitigate the impact of COVID-19 on migrants and the health of the public at large.", "doi": "10.3961/jpmph.20.235", "pmid": "32752592", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jpmph.20.235"}, {"db": "pmc", "key": "PMC7411250"}], "notes": [], "created": "2020-11-30T08:44:12.012Z", "modified": "2020-11-30T08:44:12.036Z"}, {"entity": "publication", "iuid": "12b4dcc8dc3f4da3aa0981fb96c7e217", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/12b4dcc8dc3f4da3aa0981fb96c7e217.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/12b4dcc8dc3f4da3aa0981fb96c7e217"}}, "title": "The protein expression profile of ACE2 in human tissues.", "authors": [{"family": "Hikmet", "given": "Feria", "initials": "F", "orcid": "0000-0002-3750-9308", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/511acd3a0f344f119d0986f304edda13.json"}}, {"family": "M\u00e9ar", "given": "Loren", "initials": "L"}, {"family": "Edvinsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Micke", "given": "Patrick", "initials": "P"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cfef77b64f644d498532e5e2572a8c5c.json"}}, {"family": "Lindskog", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-5611-1015", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b4ead3d38a364b66ac069b9c8bf63897.json"}}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Mol Syst Biol", "issn": "1744-4292", "issn-l": "1744-4292", "volume": "16", "issue": "7", "pages": "e9610"}, "abstract": "The novel SARS-coronavirus 2 (SARS-CoV-2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS-CoV-2 infection, the cell type-specific expression of the host cell surface receptor is necessary. The key protein suggested to be involved in host cell entry is angiotensin I converting enzyme 2 (ACE2). Here, we report the expression pattern of ACE2 across > 150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis. The results were compared with several datasets both on the mRNA and protein level. ACE2 expression was mainly observed in enterocytes, renal tubules, gallbladder, cardiomyocytes, male reproductive cells, placental trophoblasts, ductal cells, eye, and vasculature. In the respiratory system, the expression was limited, with no or only low expression in a subset of cells in a few individuals, observed by one antibody only. Our data constitute an important resource for further studies on SARS-CoV-2 host cell entry, in order to understand the biology of the disease and to aid in the development of effective treatments to the viral infection.", "doi": "10.15252/msb.20209610", "pmid": "32715618", "labels": {"Category: Biochemistry": null, "Category: Proteins": null, "Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7383091"}], "notes": [], "created": "2021-06-14T14:56:19.700Z", "modified": "2021-11-26T09:46:31.768Z"}, {"entity": "publication", "iuid": "49eeff9c7fc148e1b2f90ac1722df1c5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49eeff9c7fc148e1b2f90ac1722df1c5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49eeff9c7fc148e1b2f90ac1722df1c5"}}, "title": "The potential long-term impact of the COVID-19 outbreak on patients with non-communicable diseases in Europe: consequences for healthy ageing.", "authors": [{"family": "Palmer", "given": "Katie", "initials": "K"}, {"family": "Monaco", "given": "Alessandro", "initials": "A"}, {"family": "Kivipelto", "given": "Miia", "initials": "M"}, {"family": "Onder", "given": "Graziano", "initials": "G"}, {"family": "Maggi", "given": "Stefania", "initials": "S"}, {"family": "Michel", "given": "Jean-Pierre", "initials": "JP"}, {"family": "Prieto", "given": "Rita", "initials": "R"}, {"family": "Sykara", "given": "Georgia", "initials": "G"}, {"family": "Donde", "given": "Shaantanu", "initials": "S"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Aging Clin Exp Res", "issn": "1720-8319", "volume": "32", "issue": "7", "pages": "1189-1194", "issn-l": "1594-0667"}, "abstract": "The early stages of the COVID-19 pandemic have focused on containing SARS-CoV-2 infection and identifying treatment strategies. While controlling this communicable disease is of utmost importance, the long-term effect on individuals with non-communicable diseases (NCD) is significant. Although certain NCDs appear to increase the severity of COVID-19 and mortality risk, SARS-CoV-2 infection in survivors with NCDs may also affect the progression of their pre-existing clinical conditions. Infection containment measures will have substantial short- and long-term consequences; social distancing and quarantine restrictions will reduce physical activity and increase other unhealthy lifestyles, thus increasing NCD risk factors and worsening clinical symptoms. Vitamin D levels might decrease and there might be a rise in mental health disorders. Many countries have made changes to routine management of NCD patients, e.g., cancelling non-urgent outpatient visits, which will have important implications for NCD management, diagnosis of new-onset NCDs, medication adherence, and NCD progression. We may have opportunities to learn from this unprecedented crisis on how to leverage healthcare technologies and improve procedures to optimize healthcare service provision. This article discusses how the COVID-19 outbreak and related infection control measures could hit the most frail individuals, worsening the condition of NCD patients, while further jeopardizing the sustainability of the healthcare systems. We suggest ways to define an integrated strategy that could involve both public institutional entities and the private sector to safeguard frail individuals and mitigate the impact of the outbreak.", "doi": "10.1007/s40520-020-01601-4", "pmid": "32458356", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40520-020-01601-4"}, {"db": "pmc", "key": "PMC7248450"}], "notes": [], "created": "2020-11-25T09:17:28.876Z", "modified": "2020-11-30T09:02:33.085Z"}, {"entity": "publication", "iuid": "c81e59dc42e44e30a7c6de749c714271", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c81e59dc42e44e30a7c6de749c714271.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c81e59dc42e44e30a7c6de749c714271"}}, "title": "The Vascular Surgery COVID-19 Collaborative (VASCC).", "authors": [{"family": "Mouawad", "given": "Nicolas J", "initials": "NJ"}, {"family": "Cuff", "given": "Robert F", "initials": "RF"}, {"family": "Hultgren", "given": "Rebecka", "initials": "R"}, {"family": "Chuen", "given": "Jason", "initials": "J"}, {"family": "Galeazzi", "given": "Edoardo", "initials": "E"}, {"family": "Wohlauer", "given": "Max", "initials": "M"}], "type": "letter", "published": "2020-07-00", "journal": {"title": "J Vasc Surg", "issn": "1097-6809", "volume": "72", "issue": "1", "pages": "379-380", "issn-l": "0741-5214"}, "abstract": "Letter to the editor", "doi": "10.1016/j.jvs.2020.04.463", "pmid": "32334050", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0741-5214(20)31054-5"}, {"db": "pmc", "key": "PMC7175883"}], "notes": [], "created": "2020-11-23T11:51:10.065Z", "modified": "2020-12-09T14:58:38.311Z"}, {"entity": "publication", "iuid": "c5ba8db7add244e7afb0dc120c5eef53", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5ba8db7add244e7afb0dc120c5eef53.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5ba8db7add244e7afb0dc120c5eef53"}}, "title": "The Use of eHealth for the Care of Patients With Diabetes in Connection to the COVID-19 Pandemic.", "authors": [{"family": "Jendle", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "J Diabetes Sci Technol", "issn": "1932-2968", "volume": "14", "issue": "4", "pages": "739-740", "issn-l": null}, "abstract": null, "doi": "10.1177/1932296820922623", "pmid": "32375494", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7673160"}], "notes": [], "created": "2020-12-10T07:34:11.628Z", "modified": "2020-12-10T07:34:20.300Z"}, {"entity": "publication", "iuid": "0a8b001724604a96921c186e67b47605", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a8b001724604a96921c186e67b47605.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a8b001724604a96921c186e67b47605"}}, "title": "The COronavirus Pandemic Epidemiology (COPE) Consortium: A Call to Action.", "authors": [{"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Nguyen", "given": "Long H", "initials": "LH"}, {"family": "Joshi", "given": "Amit D", "initials": "AD"}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Guo", "given": "Chuan-Guo", "initials": "CG"}, {"family": "Lo", "given": "Chun-Han", "initials": "CH"}, {"family": "Mehta", "given": "Raaj S", "initials": "RS"}, {"family": "Kwon", "given": "Sohee", "initials": "S"}, {"family": "Sikavi", "given": "Daniel R", "initials": "DR"}, {"family": "Magicheva-Gupta", "given": "Marina V", "initials": "MV"}, {"family": "Fatehi", "given": "Zahra S", "initials": "ZS"}, {"family": "Flynn", "given": "Jacqueline J", "initials": "JJ"}, {"family": "Leonardo", "given": "Brianna M", "initials": "BM"}, {"family": "Albert", "given": "Christine M", "initials": "CM"}, {"family": "Andreotti", "given": "Gabriella", "initials": "G"}, {"family": "Beane-Freeman", "given": "Laura E", "initials": "LE"}, {"family": "Balasubramanian", "given": "Bijal A", "initials": "BA"}, {"family": "Brownstein", "given": "John S", "initials": "JS"}, {"family": "Bruinsma", "given": "Fiona", "initials": "F"}, {"family": "Cowan", "given": "Annie N", "initials": "AN"}, {"family": "Deka", "given": "Anusila", "initials": "A"}, {"family": "Ernst", "given": "Michael E", "initials": "ME"}, {"family": "Figueiredo", "given": "Jane C", "initials": "JC"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Gardner", "given": "Christopher D", "initials": "CD"}, {"family": "Ghobrial", "given": "Irene M", "initials": "IM"}, {"family": "Haiman", "given": "Christopher A", "initials": "CA"}, {"family": "Hall", "given": "Janet E", "initials": "JE"}, {"family": "Deming-Halverson", "given": "Sandra L", "initials": "SL"}, {"family": "Kirpach", "given": "Brenda", "initials": "B"}, {"family": "Lacey", "given": "James V", "initials": "JV"}, {"family": "Marchand", "given": "Lo\u00efc Le", "initials": "LL"}, {"family": "Marinac", "given": "Catherine R", "initials": "CR"}, {"family": "Martinez", "given": "Maria Elena", "initials": "ME"}, {"family": "Milne", "given": "Roger L", "initials": "RL"}, {"family": "Murray", "given": "Anne M", "initials": "AM"}, {"family": "Nash", "given": "Denis", "initials": "D"}, {"family": "Palmer", "given": "Julie R", "initials": "JR"}, {"family": "Patel", "given": "Alpa V", "initials": "AV"}, {"family": "Rosenberg", "given": "Lynn", "initials": "L"}, {"family": "Sandler", "given": "Dale P", "initials": "DP"}, {"family": "Sharma", "given": "Shreela V", "initials": "SV"}, {"family": "Schurman", "given": "Shepherd H", "initials": "SH"}, {"family": "Wilkens", "given": "Lynne R", "initials": "LR"}, {"family": "Chavarro", "given": "Jorge E", "initials": "JE"}, {"family": "Eliassen", "given": "A Heather", "initials": "AH"}, {"family": "Hart", "given": "Jaime E", "initials": "JE"}, {"family": "Kang", "given": "Jae Hee", "initials": "JH"}, {"family": "Koenen", "given": "Karestan C", "initials": "KC"}, {"family": "Kubzansky", "given": "Laura D", "initials": "LD"}, {"family": "Mucci", "given": "Lorelei A", "initials": "LA"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Rich-Edwards", "given": "Janet W", "initials": "JW"}, {"family": "Song", "given": "Mingyang", "initials": "M"}, {"family": "Stampfer", "given": "Meir J", "initials": "MJ"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Willett", "given": "Walter C", "initials": "WC"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Spector", "given": "Tim", "initials": "T"}, {"family": "COPE Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Cancer Epidemiol Biomarkers Prev", "issn": "1538-7755", "volume": "29", "issue": "7", "pages": "1283-1289", "issn-l": null}, "abstract": "The rapid pace of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; COVID-19) pandemic presents challenges to the real-time collection of population-scale data to inform near-term public health needs as well as future investigations. We established the COronavirus Pandemic Epidemiology (COPE) consortium to address this unprecedented crisis on behalf of the epidemiology research community. As a central component of this initiative, we have developed a COVID Symptom Study (previously known as the COVID Symptom Tracker) mobile application as a common data collection tool for epidemiologic cohort studies with active study participants. This mobile application collects information on risk factors, daily symptoms, and outcomes through a user-friendly interface that minimizes participant burden. Combined with our efforts within the general population, data collected from nearly 3 million participants in the United States and United Kingdom are being used to address critical needs in the emergency response, including identifying potential hot spots of disease and clinically actionable risk factors. The linkage of symptom data collected in the app with information and biospecimens already collected in epidemiology cohorts will position us to address key questions related to diet, lifestyle, environmental, and socioeconomic factors on susceptibility to COVID-19, clinical outcomes related to infection, and long-term physical, mental health, and financial sequalae. We call upon additional epidemiology cohorts to join this collective effort to strengthen our impact on the current health crisis and generate a new model for a collaborative and nimble research infrastructure that will lead to more rapid translation of our work for the betterment of public health.", "doi": "10.1158/1055-9965.EPI-20-0606", "pmid": "32371551", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "1055-9965.EPI-20-0606"}, {"db": "pmc", "key": "PMC7357669"}, {"db": "mid", "key": "NIHMS1605601"}], "notes": [], "created": "2020-11-30T09:10:08.022Z", "modified": "2020-11-30T09:10:08.046Z"}, {"entity": "publication", "iuid": "e0e15dfc412146968881757d0e0c0e1d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e0e15dfc412146968881757d0e0c0e1d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e0e15dfc412146968881757d0e0c0e1d"}}, "title": "Structure-based drug designing and immunoinformatics approach for SARS-CoV-2.", "authors": [{"family": "Panda", "given": "Pritam Kumar", "initials": "PK"}, {"family": "Arul", "given": "Murugan Natarajan", "initials": "MN"}, {"family": "Patel", "given": "Paritosh", "initials": "P"}, {"family": "Verma", "given": "Suresh K", "initials": "SK"}, {"family": "Luo", "given": "Wei", "initials": "W"}, {"family": "Rubahn", "given": "Horst-G\u00fcnter", "initials": "H"}, {"family": "Mishra", "given": "Yogendra Kumar", "initials": "YK"}, {"family": "Suar", "given": "Mrutyunjay", "initials": "M"}, {"family": "Ahuja", "given": "Rajeev", "initials": "R"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Sci Adv", "issn": "2375-2548", "issn-l": "2375-2548", "volume": "6", "issue": "28", "pages": "eabb8097"}, "abstract": "The prevalence of respiratory illness caused by the novel SARS-CoV-2 virus associated with multiple organ failures is spreading rapidly because of its contagious human-to-human transmission and inadequate globalhealth care systems. Pharmaceutical repurposing, an effective drug development technique using existing drugs, could shorten development time and reduce costs compared to those of de novo drug discovery. We carried out virtual screening of antiviral compounds targeting the spike glycoprotein (S), main protease (M pro), and the SARS-CoV-2 receptor binding domain (RBD)-angiotensin-converting enzyme 2 (ACE2) complex of SARS-CoV-2. PC786, an antiviral polymerase inhibitor, showed enhanced binding affinity to all the targets. Furthermore, the postfusion conformation of the trimeric S protein RBD with ACE2 revealed conformational changes associated with PC786 drug binding. Exploiting immunoinformatics to identify T cell and B cell epitopes could guide future experimental studies with a higher probability of discovering appropriate vaccine candidates with fewer experiments and higher reliability.", "doi": "10.1126/sciadv.abb8097", "pmid": "32691011", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Imaging": null}, "xrefs": [{"db": "pii", "key": "abb8097"}, {"db": "pmc", "key": "PMC7319274"}], "notes": [], "created": "2020-11-22T09:29:59.106Z", "modified": "2021-02-26T08:45:36.642Z"}, {"entity": "publication", "iuid": "0c693dbf11714aedb01adc0574874d49", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c693dbf11714aedb01adc0574874d49.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c693dbf11714aedb01adc0574874d49"}}, "title": "Severe maternal morbidity and mortality associated with COVID-19: The risk should not be downplayed.", "authors": [{"family": "Westgren", "given": "Magnus", "initials": "M"}, {"family": "Pettersson", "given": "Karin", "initials": "K"}, {"family": "Hagberg", "given": "Henrik", "initials": "H"}, {"family": "Acharya", "given": "Ganesh", "initials": "G"}], "type": "editorial", "published": "2020-07-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "7", "pages": "815-816", "issn-l": "0001-6349"}, "abstract": "Editorial", "doi": "10.1111/aogs.13900", "pmid": "32386440", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7273078"}], "notes": [], "created": "2020-11-25T07:50:33.073Z", "modified": "2020-12-10T07:44:28.141Z"}, {"entity": "publication", "iuid": "50ccecd135cf4a93bfc0e8d922c54278", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50ccecd135cf4a93bfc0e8d922c54278.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50ccecd135cf4a93bfc0e8d922c54278"}}, "title": "Rapid risk assessment from ECDC: Resurgence of reported cases of COVID-19 in the EU/EEA, the UK and EU candidate and potential candidate countries.", "authors": [{"family": "Eurosurveillance editorial team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "26", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.26.2007021", "pmid": "32643600", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7346365"}], "notes": [], "created": "2020-12-08T14:30:09.784Z", "modified": "2020-12-08T14:30:19.350Z"}, {"entity": "publication", "iuid": "5885b52cf6834f5dab52e3606ffac54e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5885b52cf6834f5dab52e3606ffac54e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5885b52cf6834f5dab52e3606ffac54e"}}, "title": "Public Health Agency of Sweden's Brief Report: Pregnant and postpartum women with severe acute respiratory syndrome coronavirus 2 infection in intensive care in Sweden.", "authors": [{"family": "Collin", "given": "Julius", "initials": "J"}, {"family": "Bystr\u00f6m", "given": "Emma", "initials": "E"}, {"family": "Carnahan", "given": "AnnaSara", "initials": "A"}, {"family": "Ahrne", "given": "Malin", "initials": "M"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "7", "pages": "819-822", "issn-l": "0001-6349"}, "abstract": "The Public Health Agency of Sweden has analyzed how many pregnant and postpartum women with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been treated in intensive care units (ICU) in Sweden between 19 March and 20 April 2020 compared with non-pregnant women of similar age. Cases were identified in a special reporting module within the Swedish Intensive Care Registry (SIR). Fifty-three women aged 20-45 years with SARS-CoV-2 were reported in SIR, and 13 of these women were either pregnant or postpartum (<1 week). The results indicate that the risk of being admitted to ICU may be higher in pregnant and postpartum women with laboratory-confirmed SARS-CoV-2 in Sweden, compared with non-pregnant women of similar age.", "doi": "10.1111/aogs.13901", "pmid": "32386441", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7273089"}], "notes": [], "created": "2020-12-10T07:58:07.980Z", "modified": "2021-02-26T08:45:48.195Z"}, {"entity": "publication", "iuid": "50c6a161919c4123b26f46a4f9663d4d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/50c6a161919c4123b26f46a4f9663d4d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/50c6a161919c4123b26f46a4f9663d4d"}}, "title": "Perspective: COVID-19, implications of nasal diseases and consequences for their management.", "authors": [{"family": "Jian", "given": "Li", "initials": "L"}, {"family": "Yi", "given": "Wei", "initials": "W"}, {"family": "Zhang", "given": "Nan", "initials": "N"}, {"family": "Wen", "given": "Weiping", "initials": "W"}, {"family": "Krysko", "given": "Olga", "initials": "O"}, {"family": "Song", "given": "Woo-Jung", "initials": "W"}, {"family": "Bachert", "given": "Claus", "initials": "C"}], "type": "editorial", "published": "2020-07-00", "journal": {"title": "J Allergy Clin Immunol", "issn": "1097-6825", "volume": "146", "issue": "1", "pages": "67-69", "issn-l": "0091-6749"}, "abstract": "Editorial", "doi": "10.1016/j.jaci.2020.04.030", "pmid": "32360869", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0091-6749(20)30625-4"}, {"db": "pmc", "key": "PMC7252138"}], "notes": [], "created": "2020-11-25T07:19:54.341Z", "modified": "2020-12-10T07:24:26.859Z"}, {"entity": "publication", "iuid": "a64f9d7c657f4b8188082ecd258c7b56", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a64f9d7c657f4b8188082ecd258c7b56.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a64f9d7c657f4b8188082ecd258c7b56"}}, "title": "Our Experience of Trauma Management During Novel Coronovirus 2019 (COVID-19) Pandemic in a Busy Trauma Center in Southern Iran.", "authors": [{"family": "Akbarialiabad", "given": "Hossein", "initials": "H"}, {"family": "Abdolrahimzadeh Fard", "given": "Hossein", "initials": "H"}, {"family": "Abbasi", "given": "Hamid Reza", "initials": "HR"}, {"family": "Bolandparvaz", "given": "Shahram", "initials": "S"}, {"family": "Mohseni", "given": "Shahin", "initials": "S"}, {"family": "Mehrnous", "given": "Vahid", "initials": "V"}, {"family": "Saleh", "given": "Mina", "initials": "M"}, {"family": "Roushenas", "given": "Sima", "initials": "S"}, {"family": "Paydar", "given": "Shahram", "initials": "S"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Bull Emerg Trauma", "issn": "2322-2522", "volume": "8", "issue": "3", "pages": "199-201", "issn-l": null}, "abstract": "During the past few months, the novel coronavirus 2019 (COVID-19) pandemic has significantly affected medical service provision. In Iran, it has caused around 197,000 inflictions and 9200 deaths up to June 18, 2020. While many departments turned to telehealth in this era, the trauma service should provide non-stop in presence service to the trauma victims. Our trauma center is the largest in the southwest of Iran, with the mean annual admission of 18,500 polytrauma patients. In this center, we designed a safety protocol to mitigate the spread of disease and also have a more robust case finding system, especially among asymptomatic carriers who attend hospitals based on their trauma. In brief, all unstable patients were considered SARS-COV-2 positive and were directed toward the Specialized COVID-19 related ICU. For all stable patients, history, physical examination, CXR, and lab test (Complete Blood Count, Erythrocyte Sedimentation Rate, C-Reactive Protein) were ordered before entering the wards. If there was any suspicion of COVID-19, the stable patient was admitted to the COVID-19 specialized ward. Among all 1805 patients admitted during a ten weeks interval (from January 30, 2020, to April 14, 2020), 84 had a red flag and toward to COVID-19 related wards. Of those, 67 had positive PCR or evidence in CT in favor of the COOVID-19. Moreover, during regular workups, we found that 19 completely asymptomatic trauma victims had typical Chest CT scan findings of COVID-19.", "doi": "10.30476/BEAT.2020.87029", "pmid": "32944581", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7468226"}], "notes": [], "created": "2020-12-03T15:27:34.904Z", "modified": "2021-02-26T08:45:48.547Z"}, {"entity": "publication", "iuid": "021965c398864f9b8c7a42d09c6b08d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/021965c398864f9b8c7a42d09c6b08d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/021965c398864f9b8c7a42d09c6b08d0"}}, "title": "Oncology during the COVID-19 pandemic: challenges, dilemmas and the psychosocial impact on cancer patients.", "authors": [{"family": "Tsamakis", "given": "Konstantinos", "initials": "K"}, {"family": "Gavriatopoulou", "given": "Maria", "initials": "M"}, {"family": "Schizas", "given": "Dimitrios", "initials": "D"}, {"family": "Stravodimou", "given": "Athina", "initials": "A"}, {"family": "Mougkou", "given": "Aikaterini", "initials": "A"}, {"family": "Tsiptsios", "given": "Dimitrios", "initials": "D"}, {"family": "Sioulas", "given": "Vasileios", "initials": "V"}, {"family": "Spartalis", "given": "Eleftherios", "initials": "E"}, {"family": "Sioulas", "given": "Athanasios D", "initials": "AD"}, {"family": "Tsamakis", "given": "Charalampos", "initials": "C"}, {"family": "Charalampakis", "given": "Nikolaos", "initials": "N"}, {"family": "Mueller", "given": "Christoph", "initials": "C"}, {"family": "Arya", "given": "Donna", "initials": "D"}, {"family": "Zarogoulidis", "given": "Paul", "initials": "P"}, {"family": "Spandidos", "given": "Demetrios A", "initials": "DA"}, {"family": "Dimopoulos", "given": "Meletios A", "initials": "MA"}, {"family": "Papageorgiou", "given": "Charalabos", "initials": "C"}, {"family": "Rizos", "given": "Emmanouil", "initials": "E"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Oncol Lett", "issn": "1792-1074", "volume": "20", "issue": "1", "pages": "441-447", "issn-l": null}, "abstract": "COVID-19 has caused unprecedented societal turmoil, triggering a rapid, still ongoing, transformation of healthcare provision on a global level. In this new landscape, it is highly important to acknowledge the challenges this pandemic poses on the care of the particularly vulnerable cancer patients and the subsequent psychosocial impact on them. We have outlined our clinical experience in managing patients with gastrointestinal, hematological, gynaecological, dermatological, neurological, thyroid, lung and paediatric cancers in the COVID-19 era and have reviewed the emerging literature around barriers to care of oncology patients and how this crisis affects them. Moreover, evolving treatment strategies and novel ways of addressing the needs of oncology patients in the new context of the pandemic are discussed.", "doi": "10.3892/ol.2020.11599", "pmid": "32565968", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "OL-0-0-11599"}, {"db": "pmc", "key": "PMC7285823"}], "notes": [], "created": "2020-11-26T12:16:52.516Z", "modified": "2020-11-30T08:59:19.190Z"}, {"entity": "publication", "iuid": "e8b6bd1ad99e460ca94575c9f0f8a8bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e8b6bd1ad99e460ca94575c9f0f8a8bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e8b6bd1ad99e460ca94575c9f0f8a8bd"}}, "title": "Obstetric and intensive-care strategies in a high-risk pregnancy with critical respiratory failure due to COVID-19: A case report.", "authors": [{"family": "Kolkova", "given": "Zuzana", "initials": "Z"}, {"family": "Bjurstr\u00f6m", "given": "Martin F", "initials": "MF"}, {"family": "L\u00e4nsberg", "given": "John-Kalle", "initials": "JK"}, {"family": "Svedas", "given": "Eimantas", "initials": "E"}, {"family": "Hamer", "given": "Maria Andrada", "initials": "MA"}, {"family": "Hansson", "given": "Stefan R", "initials": "SR"}, {"family": "Herbst", "given": "Andreas", "initials": "A"}, {"family": "Zaigham", "given": "Mehreen", "initials": "M"}], "type": "case reports", "published": "2020-07-00", "journal": {"title": "Case Rep Womens Health", "issn": "2214-9112", "volume": "27", "issue": null, "pages": "e00240", "issn-l": null}, "abstract": "With the disease burden increasing daily, there is a lack of evidence regarding the impact of COVID-19 in pregnancy. Healthy pregnant women are still not regarded as a susceptible group despite physiological changes that make pregnant women more vulnerable to severe infection. However, high-risk pregnancies may be associated with severe COVID-19 disease with respiratory failure, as outlined in this report. We discuss the importance of timely delivery and antenatal steroid administration in a critically ill patient.\n\nA 27-year-old pregnant woman (gravida 2, para 1) with type I diabetes, morbid obesity, hypothyroidism and a previous Caesarean section presented with critical respiratory failure secondary to COVID-19 at 32 weeks of gestation. A preterm emergency Caesarean section was performed, after steroid treatment for foetal lung maturation. The patient benefited from prone positioning; however, transient acute renal injury, rhabdomyolysis and sepsis led to prolonged intensive care and mechanical ventilation for 30 days. The baby had an uncomplicated recovery.\n\nCOVID-19 infection in high-risk pregnancies may result in severe maternal and neonatal outcomes such as critical respiratory failure requiring mechanical ventilation and premature termination of the pregnancy. Antenatal steroids may be of benefit for foetal lung maturation but should not delay delivery in severe cases.", "doi": "10.1016/j.crwh.2020.e00240", "pmid": "32714844", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S2214-9112(20)30070-9"}, {"db": "pii", "key": "e00240"}, {"db": "pmc", "key": "PMC7340590"}], "notes": [], "created": "2020-12-07T16:13:01.929Z", "modified": "2021-02-26T08:45:48.823Z"}, {"entity": "publication", "iuid": "54f00ae9073c40afbf775f85fbaa23ac", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/54f00ae9073c40afbf775f85fbaa23ac.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/54f00ae9073c40afbf775f85fbaa23ac"}}, "title": "Multimodality Cardiovascular Imaging in the Midst of the COVID-19 Pandemic: Ramping Up Safely to a New Normal.", "authors": [{"family": "Zoghbi", "given": "William A", "initials": "WA"}, {"family": "DiCarli", "given": "Marcelo F", "initials": "MF"}, {"family": "Blankstein", "given": "Ron", "initials": "R"}, {"family": "Choi", "given": "Andrew D", "initials": "AD"}, {"family": "Dilsizian", "given": "Vasken", "initials": "V"}, {"family": "Flachskampf", "given": "Frank A", "initials": "FA"}, {"family": "Geske", "given": "Jeffrey B", "initials": "JB"}, {"family": "Grayburn", "given": "Paul A", "initials": "PA"}, {"family": "Jaffer", "given": "Farouc A", "initials": "FA"}, {"family": "Kwong", "given": "Raymond Y", "initials": "RY"}, {"family": "Leipsic", "given": "Jonathan A", "initials": "JA"}, {"family": "Marwick", "given": "Thomas H", "initials": "TH"}, {"family": "Nagel", "given": "Eike", "initials": "E"}, {"family": "Nieman", "given": "Koen", "initials": "K"}, {"family": "Raman", "given": "Subha V", "initials": "SV"}, {"family": "Salerno", "given": "Michael", "initials": "M"}, {"family": "Sengupta", "given": "Partho P", "initials": "PP"}, {"family": "Shaw", "given": "Leslee J", "initials": "LJ"}, {"family": "Chandrashekhar", "given": "Y S", "initials": "YS"}, {"family": "ACC Imaging Council", "given": "", "initials": ""}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "JACC Cardiovasc Imaging", "issn": "1876-7591", "volume": "13", "issue": "7", "pages": "1615-1626", "issn-l": null}, "abstract": null, "doi": "10.1016/j.jcmg.2020.06.001", "pmid": "32646721", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1936-878X(20)30474-5"}, {"db": "pmc", "key": "PMC7290215"}], "notes": [], "created": "2020-11-30T08:51:25.555Z", "modified": "2020-11-30T08:51:25.580Z"}, {"entity": "publication", "iuid": "5fa587f8610347dca914e98d020b66eb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5fa587f8610347dca914e98d020b66eb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5fa587f8610347dca914e98d020b66eb"}}, "title": "Multidisciplinary research priorities for the COVID-19 pandemic - Authors' reply.", "authors": [{"family": "O'Connor", "given": "Rory C", "initials": "RC"}, {"family": "Hotopf", "given": "Matthew", "initials": "M"}, {"family": "Worthman", "given": "Carol M", "initials": "CM"}, {"family": "Perry", "given": "V Hugh", "initials": "VH"}, {"family": "Tracey", "given": "Irene", "initials": "I"}, {"family": "Wessely", "given": "Simon", "initials": "S"}, {"family": "Arseneault", "given": "Louise", "initials": "L"}, {"family": "Ballard", "given": "Clive", "initials": "C"}, {"family": "Christensen", "given": "Helen", "initials": "H"}, {"family": "Silver", "given": "Roxane Cohen", "initials": "RC"}, {"family": "Ford", "given": "Tamsin", "initials": "T"}, {"family": "John", "given": "Ann", "initials": "A"}, {"family": "Kabir", "given": "Thomas", "initials": "T"}, {"family": "King", "given": "Kate", "initials": "K"}, {"family": "Simpson", "given": "Alan", "initials": "A"}, {"family": "Madan", "given": "Ira", "initials": "I"}, {"family": "Cowan", "given": "Katherine", "initials": "K"}, {"family": "Bullmore", "given": "Ed", "initials": "E"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}], "type": "letter", "published": "2020-07-00", "journal": {"title": "Lancet Psychiatry", "issn": "2215-0374", "volume": "7", "issue": "7", "pages": "e44-e45", "issn-l": "2215-0366"}, "abstract": null, "doi": "10.1016/S2215-0366(20)30247-9", "pmid": "32563319", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2215-0366(20)30247-9"}, {"db": "pmc", "key": "PMC7302786"}], "notes": [], "created": "2020-11-19T19:34:04.325Z", "modified": "2020-12-08T16:42:41.940Z"}, {"entity": "publication", "iuid": "7ec0b821c62c47adb1d094adfc266824", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7ec0b821c62c47adb1d094adfc266824.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7ec0b821c62c47adb1d094adfc266824"}}, "title": "Monoclonal antibodies for the S2 subunit of spike of SARS-CoV-1 cross-react with the newly-emerged SARS-CoV-2.", "authors": [{"family": "Zheng", "given": "Zhiqiang", "initials": "Z"}, {"family": "Monteil", "given": "Vanessa Marthe", "initials": "VM"}, {"family": "Maurer-Stroh", "given": "Sebastian", "initials": "S"}, {"family": "Yew", "given": "Chow Wenn", "initials": "CW"}, {"family": "Leong", "given": "Carol", "initials": "C"}, {"family": "Mohd-Ismail", "given": "Nur Khairiah", "initials": "NK"}, {"family": "Cheyyatraivendran Arularasu", "given": "Suganya", "initials": "S"}, {"family": "Chow", "given": "Vincent Tak Kwong", "initials": "VTK"}, {"family": "Lin", "given": "Raymond Tzer Pin", "initials": "RTP"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Hong", "given": "Wanjin", "initials": "W"}, {"family": "Tan", "given": "Yee-Joo", "initials": "YJ"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "28", "issn-l": null}, "abstract": "BackgroundA novel coronavirus, SARS-CoV-2, which emerged at the end of 2019 and causes COVID-19, has resulted in worldwide human infections. While genetically distinct, SARS-CoV-1, the aetiological agent responsible for an outbreak of severe acute respiratory syndrome (SARS) in 2002-2003, utilises the same host cell receptor as SARS-CoV-2 for entry: angiotensin-converting enzyme 2 (ACE2). Parts of the SARS-CoV-1 spike glycoprotein (S protein), which interacts with ACE2, appear conserved in SARS-CoV-2.AimThe cross-reactivity with SARS-CoV-2 of monoclonal antibodies (mAbs) previously generated against the S protein of SARS-CoV-1 was assessed.MethodsThe SARS-CoV-2 S protein sequence was aligned to those of SARS-CoV-1, Middle East respiratory syndrome (MERS) and common-cold coronaviruses. Abilities of mAbs generated against SARS-CoV-1 S protein to bind SARS-CoV-2 or its S protein were tested with SARS-CoV-2 infected cells as well as cells expressing either the full length protein or a fragment of its S2 subunit. Quantitative ELISA was also performed to compare binding of mAbs to recombinant S protein.ResultsAn immunogenic domain in the S2 subunit of SARS-CoV-1 S protein is highly conserved in SARS-CoV-2 but not in MERS and human common-cold coronaviruses. Four murine mAbs raised against this immunogenic fragment could recognise SARS-CoV-2 S protein expressed in mammalian cell lines. In particular, mAb 1A9 was demonstrated to detect S protein in SARS-CoV-2-infected cells and is suitable for use in a sandwich ELISA format.ConclusionThe cross-reactive mAbs may serve as useful tools for SARS-CoV-2 research and for the development of diagnostic assays for COVID-19.", "doi": "10.2807/1560-7917.ES.2020.25.28.2000291", "pmid": "32700671", "labels": {"Type: Journal article": null, "Category: Biochemistry": null, "Category: Imaging": null}, "xrefs": [{"db": "pmc", "key": "PMC7376845"}], "notes": [], "created": "2020-12-07T16:22:09.955Z", "modified": "2021-02-26T08:45:36.612Z"}, {"entity": "publication", "iuid": "180b7ff648b8487f9227b1bee6cb8526", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/180b7ff648b8487f9227b1bee6cb8526.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/180b7ff648b8487f9227b1bee6cb8526"}}, "title": "Mobile Health Technology for Enhancing the COVID-19 Response in Africa: A Potential Game Changer?", "authors": [{"family": "Nachega", "given": "Jean B", "initials": "JB"}, {"family": "Leisegang", "given": "Rory", "initials": "R"}, {"family": "Kallay", "given": "Oscar", "initials": "O"}, {"family": "Mills", "given": "Edward J", "initials": "EJ"}, {"family": "Zumla", "given": "Alimuddin", "initials": "A"}, {"family": "Lester", "given": "Richard T", "initials": "RT"}], "type": "editorial", "published": "2020-07-00", "journal": {"title": "Am J Trop Med Hyg", "issn": "1476-1645", "volume": "103", "issue": "1", "pages": "3-5", "issn-l": "0002-9637"}, "abstract": null, "doi": "10.4269/ajtmh.20-0506", "pmid": "32476643", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7356462"}], "notes": [], "created": "2020-11-19T14:52:44.187Z", "modified": "2020-12-09T10:56:27.358Z"}, {"entity": "publication", "iuid": "da8d6c9ff2114a42b5988ab677cadb37", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/da8d6c9ff2114a42b5988ab677cadb37.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/da8d6c9ff2114a42b5988ab677cadb37"}}, "title": "Maternal mental health in the time of the COVID-19 pandemic.", "authors": [{"family": "Thapa", "given": "Suraj B", "initials": "SB"}, {"family": "Mainali", "given": "Anustha", "initials": "A"}, {"family": "Schwank", "given": "Simone E", "initials": "SE"}, {"family": "Acharya", "given": "Ganesh", "initials": "G"}], "type": "editorial", "published": "2020-07-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "7", "pages": "817-818", "issn-l": "0001-6349"}, "abstract": null, "doi": "10.1111/aogs.13894", "pmid": "32374420", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7267371"}], "notes": [], "created": "2020-12-10T07:33:05.949Z", "modified": "2020-12-10T07:35:13.106Z"}, {"entity": "publication", "iuid": "2151e438279c4482b86b2b0c8239b4a4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2151e438279c4482b86b2b0c8239b4a4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2151e438279c4482b86b2b0c8239b4a4"}}, "title": "Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies.", "authors": [{"family": "Zaigham", "given": "Mehreen", "initials": "M"}, {"family": "Andersson", "given": "Ola", "initials": "O"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "7", "pages": "823-829", "issn-l": "0001-6349"}, "abstract": "The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has exposed vulnerable populations to an unprecedented global health crisis. The knowledge gained from previous human coronavirus outbreaks suggests that pregnant women and their fetuses are particularly susceptible to poor outcomes. The objective of this study was to summarize the clinical manifestations and maternal and perinatal outcomes of COVID-19 during pregnancy.\n\nWe searched databases for all case reports and series from 12 February to 4 April 2020. Multiple terms and combinations were used including COVID-19, pregnancy, maternal mortality, maternal morbidity, complications, clinical manifestations, neonatal morbidity, intrauterine fetal death, neonatal mortality and SARS-CoV-2. Eligibility criteria included peer-reviewed publications written in English or Chinese and quantitative real-time polymerase chain reaction (PCR) or dual fluorescence PCR-confirmed SARS-CoV-2 infection. Unpublished reports, unspecified date and location of the study or suspicion of duplicate reporting, cases with suspected COVID-19 that were not confirmed by a laboratory test, and unreported maternal or perinatal outcomes were excluded. Data on clinical manifestations, maternal and perinatal outcomes including vertical transmission were extracted and analyzed.\n\nEighteen articles reporting data from 108 pregnancies between 8 December 2019 and 1 April 2020 were included in the current study. Most reports described women presenting in the third trimester with fever (68%) and coughing (34%). Lymphocytopenia (59%) with elevated C-reactive protein (70%) was observed and 91% of the women were delivered by cesarean section. Three maternal intensive care unit admissions were noted but no maternal deaths. One neonatal death and one intrauterine death were also reported.\n\nAlthough the majority of mothers were discharged without any major complications, severe maternal morbidity as a result of COVID-19 and perinatal deaths were reported. Vertical transmission of the COVID-19 could not be ruled out. Careful monitoring of pregnancies with COVID-19 and measures to prevent neonatal infection are warranted.", "doi": "10.1111/aogs.13867", "pmid": "32259279", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7262097"}], "notes": [], "created": "2020-11-30T15:55:39.008Z", "modified": "2020-11-30T15:55:39.021Z"}, {"entity": "publication", "iuid": "96eef9ada9a44102903b21f3f0ac210b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/96eef9ada9a44102903b21f3f0ac210b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/96eef9ada9a44102903b21f3f0ac210b"}}, "title": "Management of a COVID-19 outbreak in a hotel in Tenerife, Spain.", "authors": [{"family": "Hoefer", "given": "Andreas", "initials": "A"}, {"family": "Pampaka", "given": "Despina", "initials": "D"}, {"family": "Rivas Wagner", "given": "Eva", "initials": "E"}, {"family": "Alem\u00e1n Herrera", "given": "Araceli", "initials": "A"}, {"family": "Garc\u00eda-Ramos Alonso", "given": "Eduardo", "initials": "E"}, {"family": "L\u00f3pez-Perea", "given": "Noem\u00ed", "initials": "N"}, {"family": "Cano Portero", "given": "Rosa", "initials": "R"}, {"family": "Herrera-Le\u00f3n", "given": "Laura", "initials": "L"}, {"family": "Herrera-Le\u00f3n", "given": "Silvia", "initials": "S"}, {"family": "N\u00fa\u00f1ez Gallo", "given": "Domingo", "initials": "D"}], "type": "case reports", "published": "2020-07-00", "journal": {"title": "Int J Infect Dis", "issn": "1878-3511", "issn-l": "1201-9712", "volume": "96", "issue": null, "pages": "384-386"}, "abstract": "Since the first accounts of SARS-CoV-2, authorities have encountered numerous unprecedented situations threatening public health. This rapid communication addresses events that led to the quarantining of a hotel in Tenerife, Spain and the effectiveness of the rapidly implemented control measures. In total, eight cases have been associated with the hotel. Due to the international nature of the guests, had these timely precautions not been in place, a multinational cluster might have formed.", "doi": "10.1016/j.ijid.2020.05.047", "pmid": "32425635", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1201-9712(20)30354-4"}, {"db": "pmc", "key": "PMC7231486"}], "notes": [], "created": "2020-12-09T11:43:15.406Z", "modified": "2020-12-09T11:43:54.389Z"}, {"entity": "publication", "iuid": "b8f85e06a4644e5c9870905c0125d822", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b8f85e06a4644e5c9870905c0125d822.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b8f85e06a4644e5c9870905c0125d822"}}, "title": "International expert consensus statement regarding radiotherapy treatment options for rectal cancer during the COVID 19 pandemic.", "authors": [{"family": "Marijnen", "given": "C A M", "initials": "CAM"}, {"family": "Peters", "given": "F P", "initials": "FP"}, {"family": "R\u00f6del", "given": "C", "initials": "C"}, {"family": "Bujko", "given": "K", "initials": "K"}, {"family": "Haustermans", "given": "K", "initials": "K"}, {"family": "Fokas", "given": "E", "initials": "E"}, {"family": "Glynne-Jones", "given": "R", "initials": "R"}, {"family": "Valentini", "given": "V", "initials": "V"}, {"family": "Spindler", "given": "K-L G", "initials": "KG"}, {"family": "Guren", "given": "M G", "initials": "MG"}, {"family": "Maingon", "given": "Philippe", "initials": "P"}, {"family": "Calvo", "given": "F A", "initials": "FA"}, {"family": "Pares", "given": "O", "initials": "O"}, {"family": "Glimelius", "given": "B", "initials": "B"}, {"family": "Sebag-Montefiore", "given": "D", "initials": "D"}], "type": "letter", "published": "2020-07-00", "journal": {"title": "Radiother Oncol", "issn": "1879-0887", "volume": "148", "issue": null, "pages": "213-215", "issn-l": "0167-8140"}, "abstract": null, "doi": "10.1016/j.radonc.2020.03.039", "pmid": "32342861", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0167-8140(20)30173-0"}, {"db": "pmc", "key": "PMC7194592"}], "notes": [], "created": "2020-12-10T07:14:52.505Z", "modified": "2020-12-10T07:16:00.513Z"}, {"entity": "publication", "iuid": "ec472b86cef64d62be6ea9374a1da38d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ec472b86cef64d62be6ea9374a1da38d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ec472b86cef64d62be6ea9374a1da38d"}}, "title": "International Organization for the Study of IBD Recommendations for Surgery in Patients With IBD During the Coronavirus Disease 2019 Pandemic.", "authors": [{"family": "Remzi", "given": "Feza H", "initials": "FH"}, {"family": "Panis", "given": "Yves", "initials": "Y"}, {"family": "Spinelli", "given": "Antonino", "initials": "A"}, {"family": "Kotze", "given": "Paulo G", "initials": "PG"}, {"family": "Mantzaris", "given": "Gerassimos", "initials": "G"}, {"family": "S\u00f6derholm", "given": "Johan D", "initials": "JD"}, {"family": "d'Hoore", "given": "Andr\u00e9", "initials": "A"}, {"family": "Bemelman", "given": "Willem A", "initials": "WA"}, {"family": "Yamamoto", "given": "Takayuki", "initials": "T"}, {"family": "Pemberton", "given": "John H", "initials": "JH"}, {"family": "Tiret", "given": "Emmanuel", "initials": "E"}, {"family": "\u00d8resland", "given": "Tom", "initials": "T"}, {"family": "Fleshner", "given": "Phillip", "initials": "P"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Dis Colon Rectum", "issn": "1530-0358", "volume": "63", "issue": "7", "pages": "870-873", "issn-l": null}, "abstract": null, "doi": "10.1097/DCR.0000000000001718", "pmid": "32355056", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-10T07:16:56.833Z", "modified": "2020-12-10T07:17:39.381Z"}, {"entity": "publication", "iuid": "0179eb6762e54a4ca86be4f91c1ebc5d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0179eb6762e54a4ca86be4f91c1ebc5d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0179eb6762e54a4ca86be4f91c1ebc5d"}}, "title": "Impact of COVID-19 on Prostate Cancer Management: Guidelines for Urologists.", "authors": [{"family": "Dovey", "given": "Zachary", "initials": "Z"}, {"family": "Mohamed", "given": "Nihal", "initials": "N"}, {"family": "Gharib", "given": "Yasmine", "initials": "Y"}, {"family": "Ratnani", "given": "Parita", "initials": "P"}, {"family": "Hammouda", "given": "Nada", "initials": "N"}, {"family": "Nair", "given": "Sujit S", "initials": "SS"}, {"family": "Chakravarty", "given": "Dimple", "initials": "D"}, {"family": "Sobotka", "given": "Stanislaw", "initials": "S"}, {"family": "Lantz", "given": "Anna", "initials": "A"}, {"family": "Wiklund", "given": "Peter", "initials": "P"}, {"family": "Kyprianou", "given": "Natasha", "initials": "N"}, {"family": "Tewari", "given": "Ash", "initials": "A"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Eur Urol Open Sci", "issn": "2666-1683", "volume": "20", "pages": "1-11", "issn-l": null}, "abstract": "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has resulted in a global health emergency, the like of which has never been seen before. Prostate cancer (PCa) services across the globe have been on hold due to changing medical and surgical priorities. There is also epidemiological evidence that PCa patients have increased incidence and mortality from SARS-CoV-2 infection due to gender differences, age, and higher propensity for risk factors (eg, respiratory disease, obesity, hypertension, and smoking status).\n\nTo contribute to the emerging body of knowledge on the risks of SARS-CoV-2 infection to PCa patients and, in the face of PCa treatment delays, provide evidence-based recommendations for ongoing management of specific PCa patient groups.\n\nA literature search was performed using all sources (MEDLINE, EMBASE, ScienceDirect, Cochrane Libraries, and Web of Science) as well as the media to harness emerging data on the SARS-CoV-2 pandemic and its influence on PCa. Eligibility criteria were originality of data and relevance to PCa management. The authors note that during these unprecedented times, retrospective data are constantly being updated from multiple sources globally.\n\nA total of 72 articles and data sources were found initially. Owing to repetition, lack of originality, or nonrelevance, six articles were rejected, leaving 23 retrospective studies, seven basic science research articles, 15 societal and journal guidelines, and 21 epidemiological data sources, from countries at different stages of SARS-CoV-2 pandemic. These were analyzed qualitatively to produce evidence-based guidelines for the management of PCa patients at different stages of the patient journey, with strategies to reduce the risk of viral spread.\n\nPCa patients may have an increased risk of SARS-CoV-2 infection as well as morbidity and mortality if infected. Once appropriately triaged, and to reduce viral spread, PCa patients can have surveillance by telemedicine, and institute lifestyle changes and social quarantining measures. If risk stratification suggests that treatment should be planned, androgen deprivation therapy can be started, or potentially surgery or radiation therapy is possible on a case-by-case basis.\n\nProstate cancer patients can be followed up remotely until the severe acute respiratory syndrome coronavirus 2 pandemic resolves, but higher-risk cases may have treatment expedited to limit any negative impact on prostate cancer outcomes.", "doi": "10.1016/j.euros.2020.05.005", "pmid": "34173542", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S2666-1683(20)35112-0"}, {"db": "pmc", "key": "PMC7296308"}], "notes": [], "created": "2021-06-28T18:10:08.713Z", "modified": "2021-06-28T18:10:08.739Z"}, {"entity": "publication", "iuid": "f696e692cb204174b59deef6989d8d6a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f696e692cb204174b59deef6989d8d6a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f696e692cb204174b59deef6989d8d6a"}}, "title": "Illegal Online Sexual Behavior During the COVID-19 Pandemic: A Call for Action Based on Experiences From the Ongoing Prevent It Research Study.", "authors": [{"family": "Parks", "given": "Allison", "initials": "A"}, {"family": "Sparre", "given": "Charlotte", "initials": "C"}, {"family": "S\u00f6derquist", "given": "Elin", "initials": "E"}, {"family": "Arver", "given": "Stefan", "initials": "S"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Kaldo", "given": "Viktor", "initials": "V"}, {"family": "G\u00f6rts-\u00d6berg", "given": "Katarina", "initials": "K"}, {"family": "Rahm", "given": "Christoffer", "initials": "C"}], "type": "letter", "published": "2020-07-00", "journal": {"title": "Arch Sex Behav", "issn": "1573-2800", "issn-l": "0004-0002", "volume": "49", "issue": "5", "pages": "1433-1435"}, "abstract": null, "doi": "10.1007/s10508-020-01750-7", "pmid": "32488645", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s10508-020-01750-7"}, {"db": "pmc", "key": "PMC7266414"}], "notes": [], "created": "2020-11-25T09:30:06.115Z", "modified": "2020-12-11T12:58:18.631Z"}, {"entity": "publication", "iuid": "13ebcfe1236a492abaaf8d03a0b655b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13ebcfe1236a492abaaf8d03a0b655b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13ebcfe1236a492abaaf8d03a0b655b0"}}, "title": "Handling of allergen immunotherapy in the COVID-19 pandemic: An ARIA-EAACI statement.", "authors": [{"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Jutel", "given": "Marek", "initials": "M"}, {"family": "Akdis", "given": "Cezmi", "initials": "C"}, {"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Akdis", "given": "M\u00fcbeccel", "initials": "M"}, {"family": "Bachert", "given": "Claus", "initials": "C"}, {"family": "Agache", "given": "Ioana", "initials": "I"}, {"family": "Ansotegui", "given": "Ignacio", "initials": "I"}, {"family": "Bedbrook", "given": "Anna", "initials": "A"}, {"family": "Bosnic-Anticevich", "given": "Sinthia", "initials": "S"}, {"family": "Canonica", "given": "Giorgio W", "initials": "GW"}, {"family": "Chivato", "given": "Tomas", "initials": "T"}, {"family": "Cruz", "given": "Alvaro A", "initials": "AA"}, {"family": "Czarlewski", "given": "Wienia", "initials": "W"}, {"family": "Del Giacco", "given": "Stefano", "initials": "S"}, {"family": "Du", "given": "Hui", "initials": "H"}, {"family": "Fonseca", "given": "Joao A", "initials": "JA"}, {"family": "Gao", "given": "Yadong", "initials": "Y"}, {"family": "Haahtela", "given": "Tari", "initials": "T"}, {"family": "Hoffmann-Sommergruber", "given": "Karin", "initials": "K"}, {"family": "Ivancevich", "given": "Juan-Carlos", "initials": "J"}, {"family": "Khaltaev", "given": "Nikolai", "initials": "N"}, {"family": "Knol", "given": "Edward F", "initials": "EF"}, {"family": "Kuna", "given": "Piotr", "initials": "P"}, {"family": "Larenas-Linnemann", "given": "Desiree", "initials": "D"}, {"family": "Melen", "given": "Erik", "initials": "E"}, {"family": "Mullol", "given": "Joaquim", "initials": "J"}, {"family": "Naclerio", "given": "Robert", "initials": "R"}, {"family": "Ohta", "given": "Ken", "initials": "K"}, {"family": "Okamoto", "given": "Yoshitaka", "initials": "Y"}, {"family": "O'Mahony", "given": "Liam", "initials": "L"}, {"family": "Onorato", "given": "Gabrielle L", "initials": "GL"}, {"family": "Papadopoulos", "given": "Nikos G", "initials": "NG"}, {"family": "Pawankar", "given": "Ruby", "initials": "R"}, {"family": "Pfaar", "given": "Oliver", "initials": "O"}, {"family": "Samolinski", "given": "Boleslaw", "initials": "B"}, {"family": "Schwarze", "given": "Jurgen", "initials": "J"}, {"family": "Toppila-Salmi", "given": "Sanna", "initials": "S"}, {"family": "Shamji", "given": "Mohamed H", "initials": "MH"}, {"family": "Teresa Ventura", "given": "Maria", "initials": "M"}, {"family": "Valiulis", "given": "Arunas", "initials": "A"}, {"family": "Yorgancioglu", "given": "Arzu", "initials": "A"}, {"family": "Matricardi", "given": "Paolo", "initials": "P"}, {"family": "Zuberbier", "given": "Torsten", "initials": "T"}, {"family": "ARIA-MASK Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": "75", "issue": "7", "pages": "1546-1554", "issn-l": "0105-4538"}, "abstract": null, "doi": "10.1111/all.14336", "pmid": "32329930", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7264744"}], "notes": [], "created": "2020-11-23T11:47:55.525Z", "modified": "2020-11-23T11:48:33.320Z"}, {"entity": "publication", "iuid": "7156626f870e4e5987ce1779717d55b5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7156626f870e4e5987ce1779717d55b5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7156626f870e4e5987ce1779717d55b5"}}, "title": "Excess all-cause mortality during the COVID-19 pandemic in Europe - preliminary pooled estimates from the EuroMOMO network, March to April 2020.", "authors": [{"family": "Vestergaard", "given": "Lasse S", "initials": "LS"}, {"family": "Nielsen", "given": "Jens", "initials": "J"}, {"family": "Richter", "given": "Lukas", "initials": "L"}, {"family": "Schmid", "given": "Daniela", "initials": "D"}, {"family": "Bustos", "given": "Natalia", "initials": "N"}, {"family": "Braeye", "given": "Toon", "initials": "T"}, {"family": "Denissov", "given": "Gleb", "initials": "G"}, {"family": "Veideman", "given": "Tatjana", "initials": "T"}, {"family": "Luomala", "given": "Oskari", "initials": "O"}, {"family": "M\u00f6tt\u00f6nen", "given": "Teemu", "initials": "T"}, {"family": "Fouillet", "given": "Anne", "initials": "A"}, {"family": "Caserio-Sch\u00f6nemann", "given": "C\u00e9line", "initials": "C"}, {"family": "An der Heiden", "given": "Matthias", "initials": "M"}, {"family": "Uphoff", "given": "Helmut", "initials": "H"}, {"family": "Lytras", "given": "Theodore", "initials": "T"}, {"family": "Gkolfinopoulou", "given": "Kassiani", "initials": "K"}, {"family": "Paldy", "given": "Anna", "initials": "A"}, {"family": "Domegan", "given": "Lisa", "initials": "L"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}, {"family": "De' Donato", "given": "Francesca", "initials": "F"}, {"family": "Noccioli", "given": "Fiammetta", "initials": "F"}, {"family": "Hoffmann", "given": "Patrick", "initials": "P"}, {"family": "Velez", "given": "Telma", "initials": "T"}, {"family": "England", "given": "Kathleen", "initials": "K"}, {"family": "van Asten", "given": "Liselotte", "initials": "L"}, {"family": "White", "given": "Richard A", "initials": "RA"}, {"family": "T\u00f8nnessen", "given": "Ragnhild", "initials": "R"}, {"family": "da Silva", "given": "Susana P", "initials": "SP"}, {"family": "Rodrigues", "given": "Ana P", "initials": "AP"}, {"family": "Larrauri", "given": "Amparo", "initials": "A"}, {"family": "Delgado-Sanz", "given": "Concepci\u00f3n", "initials": "C"}, {"family": "Farah", "given": "Ahmed", "initials": "A"}, {"family": "Galanis", "given": "Ilias", "initials": "I"}, {"family": "Junker", "given": "Christoph", "initials": "C"}, {"family": "Perisa", "given": "Damir", "initials": "D"}, {"family": "Sinnathamby", "given": "Mary", "initials": "M"}, {"family": "Andrews", "given": "Nick", "initials": "N"}, {"family": "O'Doherty", "given": "Mark", "initials": "M"}, {"family": "Marquess", "given": "Diogo Fp", "initials": "DF"}, {"family": "Kennedy", "given": "Sharon", "initials": "S"}, {"family": "Olsen", "given": "Sonja J", "initials": "SJ"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "ECDC Public Health Emergency Team for COVID-19", "given": "", "initials": ""}, {"family": "Krause", "given": "Tyra G", "initials": "TG"}, {"family": "M\u00f8lbak", "given": "K\u00e5re", "initials": "K"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "26", "issn-l": null}, "abstract": "A remarkable excess mortality has coincided with the COVID-19 pandemic in Europe. We present preliminary pooled estimates of all-cause mortality for 24 European countries/federal states participating in the European monitoring of excess mortality for public health action (EuroMOMO) network, for the period March-April 2020. Excess mortality particularly affected \u2265 65 year olds (91% of all excess deaths), but also 45-64 (8%) and 15-44 year olds (1%). No excess mortality was observed in 0-14 year olds.", "doi": "10.2807/1560-7917.ES.2020.25.26.2001214", "pmid": "32643601", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7346364"}], "notes": [], "created": "2020-12-08T14:29:31.649Z", "modified": "2020-12-08T14:29:31.659Z"}, {"entity": "publication", "iuid": "edf06ad57a0542d6a1ecd42c8c6c3cc2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/edf06ad57a0542d6a1ecd42c8c6c3cc2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/edf06ad57a0542d6a1ecd42c8c6c3cc2"}}, "title": "European Society for Neurogastroenterology and Motility recommendations for conducting gastrointestinal motility and function testing in the recovery phase of the COVID-19 pandemic.", "authors": [{"family": "Tack", "given": "Jan", "initials": "J"}, {"family": "Vanuytsel", "given": "Tim", "initials": "T"}, {"family": "Serra", "given": "Jordi", "initials": "J"}, {"family": "Accarino", "given": "Anna", "initials": "A"}, {"family": "Stanghellini", "given": "Vincenzo", "initials": "V"}, {"family": "Barbara", "given": "Giovanni", "initials": "G"}, {"family": "ESNM Consensus Group, the Leuven Consensus Group, the Italian Consensus Group, the Spanish Consensus Group on function testing in the COVID-19 pandemic era", "given": "", "initials": ""}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Neurogastroenterol Motil", "issn": "1365-2982", "volume": "32", "issue": "7", "pages": "e13930", "issn-l": null}, "abstract": "During the peak of the COronaVIrus Disease 2019 (COVID-19) pandemic, care for patients with gastrointestinal motility and functional disorders was largely suspended. In the recovery phases of the pandemic, non-urgent medical care is resumed, but there is a lack of guidance for restarting and safely conducting motility and function testing. Breath tests and insertion of manometry and pH-monitoring probes carry a risk of SARS-CoV-2 spread through droplet formation.\n\nA panel of experts from the European Society for Neurogastroenterology and Motility (ESNM) evaluated emerging national and single-center recommendations to provide the best current evidence and a pragmatic approach to ensure the safe conduct of motility and function testing for both healthcare professionals and patients.\n\nAt a general level, this involves evaluation of the urgency of the procedure, evaluation of the infectious risk associated with the patient, the investigation and the healthcare professional(s) involved, provision of the test planning and test units, education and training of staff, and use of personnel protection equipment. Additional guidance is provided for specific procedures such as esophageal manometry, pH monitoring, and breath tests.\n\nThe ESNM guidelines provide pragmatic and appropriate guidance for the safe conduct of motility and function testing in the COVID-19 pandemic and early recovery phase.", "doi": "10.1111/nmo.13930", "pmid": "32525249", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7300574"}], "notes": [], "created": "2020-12-09T10:07:33.877Z", "modified": "2020-12-09T10:07:33.899Z"}, {"entity": "publication", "iuid": "8af419f2fae34df29919e6ee13faddcc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8af419f2fae34df29919e6ee13faddcc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8af419f2fae34df29919e6ee13faddcc"}}, "title": "European Association of Urology Guidelines Office Rapid Reaction Group: An Organisation-wide Collaborative Effort to Adapt the European Association of Urology Guidelines Recommendations to the Coronavirus Disease 2019 Era.", "authors": [{"family": "Ribal", "given": "Maria J", "initials": "MJ"}, {"family": "Cornford", "given": "Philip", "initials": "P"}, {"family": "Briganti", "given": "Alberto", "initials": "A"}, {"family": "Knoll", "given": "Thomas", "initials": "T"}, {"family": "Gravas", "given": "Stavros", "initials": "S"}, {"family": "Babjuk", "given": "Marek", "initials": "M"}, {"family": "Harding", "given": "Christopher", "initials": "C"}, {"family": "Breda", "given": "Alberto", "initials": "A"}, {"family": "Bex", "given": "Axel", "initials": "A"}, {"family": "GORRG Group", "given": "", "initials": ""}, {"family": "Rassweiler", "given": "Jens J", "initials": "JJ"}, {"family": "G\u00f6zen", "given": "Ali S", "initials": "AS"}, {"family": "Pini", "given": "Giovannalberto", "initials": "G"}, {"family": "Liatsikos", "given": "Evangelos", "initials": "E"}, {"family": "Giannarini", "given": "Gianluca", "initials": "G"}, {"family": "Mottrie", "given": "Alex", "initials": "A"}, {"family": "Subramaniam", "given": "Ramnath", "initials": "R"}, {"family": "Sofikitis", "given": "Nikolaos", "initials": "N"}, {"family": "Rocco", "given": "Bernardo M C", "initials": "BMC"}, {"family": "Xie", "given": "Li-Ping", "initials": "LP"}, {"family": "Witjes", "given": "J Alfred", "initials": "JA"}, {"family": "Mottet", "given": "Nicolas", "initials": "N"}, {"family": "Ljungberg", "given": "B\u00f6rje", "initials": "B"}, {"family": "Roupr\u00eat", "given": "Morgan", "initials": "M"}, {"family": "Laguna", "given": "Maria P", "initials": "MP"}, {"family": "Salonia", "given": "Andrea", "initials": "A"}, {"family": "Bonkat", "given": "Gernot", "initials": "G"}, {"family": "Blok", "given": "Bertil F M", "initials": "BFM"}, {"family": "T\u00fcrk", "given": "Christian", "initials": "C"}, {"family": "Radmayr", "given": "Christian", "initials": "C"}, {"family": "Kitrey", "given": "Noam D", "initials": "ND"}, {"family": "Engeler", "given": "Daniel S", "initials": "DS"}, {"family": "Lumen", "given": "Nicolaas", "initials": "N"}, {"family": "Hakenberg", "given": "Oliver W", "initials": "OW"}, {"family": "Watkin", "given": "Nick", "initials": "N"}, {"family": "Hamid", "given": "Rizwan", "initials": "R"}, {"family": "Olsburgh", "given": "Jonathon", "initials": "J"}, {"family": "Darraugh", "given": "Julie", "initials": "J"}, {"family": "Shepherd", "given": "Robert", "initials": "R"}, {"family": "Smith", "given": "Emma-Jane", "initials": "EJ"}, {"family": "Chapple", "given": "Christopher R", "initials": "CR"}, {"family": "Stenzl", "given": "Arnulf", "initials": "A"}, {"family": "Van Poppel", "given": "Hendrik", "initials": "H"}, {"family": "Wirth", "given": "Manfred", "initials": "M"}, {"family": "S\u00f8nksen", "given": "Jens", "initials": "J"}, {"family": "N'Dow", "given": "James", "initials": "J"}, {"family": "EAU Section Offices and the EAU Guidelines Panels", "given": "", "initials": ""}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Eur Urol", "issn": "1873-7560", "volume": "78", "issue": "1", "pages": "21-28", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic is unlike anything seen before by modern science-based medicine. Health systems across the world are struggling to manage it. Added to this struggle are the effects of social confinement and isolation. This brings into question whether the latest guidelines are relevant in this crisis. We aim to support urologists in this difficult situation by providing tools that can facilitate decision making, and to minimise the impact and risks for both patients and health professionals delivering urological care, whenever possible. We hope that the revised recommendations will assist urologist surgeons across the globe to guide the management of urological conditions during the current COVID-19 pandemic.", "doi": "10.1016/j.eururo.2020.04.056", "pmid": "32376137", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0302-2838(20)30324-9"}, {"db": "pmc", "key": "PMC7183974"}], "notes": [], "created": "2020-12-10T07:36:06.469Z", "modified": "2020-12-10T07:36:06.491Z"}, {"entity": "publication", "iuid": "72356b6b1430403297ae0fd5a1af6e57", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/72356b6b1430403297ae0fd5a1af6e57.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/72356b6b1430403297ae0fd5a1af6e57"}}, "title": "Ethical triage during the COVID-19 pandemic: a toolkit for neurosurgical resource allocation.", "authors": [{"family": "Hulsbergen", "given": "Alexander F C", "initials": "AFC"}, {"family": "Eijkholt", "given": "Marleen M", "initials": "MM"}, {"family": "Balak", "given": "Naci", "initials": "N"}, {"family": "Brennum", "given": "Jannick", "initials": "J"}, {"family": "Bolger", "given": "Ciar\u00e1n", "initials": "C"}, {"family": "Bohrer", "given": "Anna-Margarete", "initials": "AM"}, {"family": "Feldman", "given": "Zeev", "initials": "Z"}, {"family": "Holsgrove", "given": "Daniel", "initials": "D"}, {"family": "Kitchen", "given": "Neil", "initials": "N"}, {"family": "Mathiesen", "given": "Tiit I", "initials": "TI"}, {"family": "Moojen", "given": "Wouter A", "initials": "WA"}, {"family": "Sampr\u00f3n", "given": "Nicol\u00e1s", "initials": "N"}, {"family": "Sames", "given": "Martin", "initials": "M"}, {"family": "Sandvik", "given": "Ulrika", "initials": "U"}, {"family": "Tisell", "given": "Magnus", "initials": "M"}, {"family": "Broekman", "given": "Marike L D", "initials": "MLD"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Acta Neurochir (Wien)", "issn": "0942-0940", "volume": "162", "issue": "7", "pages": "1485-1490", "issn-l": "0001-6268"}, "abstract": "The COVID-19 pandemic confronts healthcare workers, including neurosurgeons, with difficult choices regarding which patients to treat.\n\nIn order to assist ethical triage, this article gives an overview of the main considerations and ethical principles relevant when allocating resources in times of scarcity.\n\nWe discuss a framework employing four principles: prioritizing the worst off, maximizing benefits, treating patients equally, and promoting instrumental value. We furthermore discuss the role of age and comorbidity in triage and highlight some principles that may seem intuitive but should not form a basis for triage.\n\nThis overview is presented on behalf of the European Association of Neurosurgical Societies and can be used as a toolkit for neurosurgeons faced with ethical dilemmas when triaging patients in times of scarcity.", "doi": "10.1007/s00701-020-04375-w", "pmid": "32405671", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00701-020-04375-w"}, {"db": "pmc", "key": "PMC7220806"}], "notes": [], "created": "2020-11-25T08:04:50.218Z", "modified": "2020-11-30T09:07:55.694Z"}, {"entity": "publication", "iuid": "9b890af069da4a43983d613b4392d539", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b890af069da4a43983d613b4392d539.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b890af069da4a43983d613b4392d539"}}, "title": "Development of passive immunity against SARS-CoV-2 for management of immunodeficient patients-a perspective.", "authors": [{"family": "Hammarstr\u00f6m", "given": "Lennart", "initials": "L"}, {"family": "Abolhassani", "given": "Hassan", "initials": "H"}, {"family": "Baldanti", "given": "Fausto", "initials": "F"}, {"family": "Marcotte", "given": "Harold", "initials": "H"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}], "type": "editorial", "published": "2020-07-00", "journal": {"title": "J Allergy Clin Immunol", "issn": "1097-6825", "issn-l": "0091-6749", "volume": "146", "issue": "1", "pages": "58-60"}, "abstract": "Editorial", "doi": "10.1016/j.jaci.2020.04.043", "pmid": "32413374", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: H2020": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0091-6749(20)30645-X"}, {"db": "pmc", "key": "PMC7215168"}], "notes": [], "created": "2020-11-25T08:26:38.332Z", "modified": "2021-02-26T08:45:48.511Z"}, {"entity": "publication", "iuid": "449b2397650449f9adffd907a41a9b9d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/449b2397650449f9adffd907a41a9b9d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/449b2397650449f9adffd907a41a9b9d"}}, "title": "COVID-19, chronic inflammatory respiratory diseases and eosinophils-Observations from reported clinical case series.", "authors": [{"family": "Jesenak", "given": "Milos", "initials": "M"}, {"family": "Banovcin", "given": "Peter", "initials": "P"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}], "type": "letter", "published": "2020-07-00", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": "75", "issue": "7", "pages": "1819-1822", "issn-l": "0105-4538"}, "abstract": null, "doi": "10.1111/all.14353", "pmid": "32369190", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-10T07:28:22.865Z", "modified": "2020-12-10T07:28:22.875Z"}, {"entity": "publication", "iuid": "8fc1af79aa724fc4bf30f7dd2e362aff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8fc1af79aa724fc4bf30f7dd2e362aff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8fc1af79aa724fc4bf30f7dd2e362aff"}}, "title": "COVID-19 in pregnancy with comorbidities: More liberal testing strategy is needed.", "authors": [{"family": "Gidl\u00f6f", "given": "Sebastian", "initials": "S"}, {"family": "Savchenko", "given": "Julia", "initials": "J"}, {"family": "Brune", "given": "Thomas", "initials": "T"}, {"family": "Josefsson", "given": "Hampus", "initials": "H"}], "type": "letter", "published": "2020-07-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "7", "pages": "948-949", "issn-l": "0001-6349"}, "abstract": null, "doi": "10.1111/aogs.13862", "pmid": "32249924", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-22T17:08:12.943Z", "modified": "2020-12-09T11:49:29.739Z"}, {"entity": "publication", "iuid": "f546322941284eb1a9ff39d0517dfcdd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f546322941284eb1a9ff39d0517dfcdd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f546322941284eb1a9ff39d0517dfcdd"}}, "title": "COVID-19 in People With Diabetes: Urgently Needed Lessons From Early Reports.", "authors": [{"family": "Riddle", "given": "Matthew C", "initials": "MC"}, {"family": "Buse", "given": "John B", "initials": "JB"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Knowler", "given": "William C", "initials": "WC"}, {"family": "Ratner", "given": "Robert E", "initials": "RE"}, {"family": "Selvin", "given": "Elizabeth", "initials": "E"}, {"family": "Wexler", "given": "Deborah J", "initials": "DJ"}, {"family": "Kahn", "given": "Steven E", "initials": "SE"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Diabetes Care", "issn": "1935-5548", "volume": "43", "issue": "7", "pages": "1378-1381", "issn-l": null}, "abstract": null, "doi": "10.2337/dci20-0024", "pmid": "32409505", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "dci20-0024"}, {"db": "pmc", "key": "PMC7305002"}], "notes": [], "created": "2020-12-10T08:50:46.407Z", "modified": "2020-12-10T08:50:46.431Z"}, {"entity": "publication", "iuid": "fb335d814dd541c58f67290f3969d67f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fb335d814dd541c58f67290f3969d67f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fb335d814dd541c58f67290f3969d67f"}}, "title": "COVID-19 Pandemic: Consensus guidelines for preferred practices in an aesthetic clinic.", "authors": [{"family": "Kapoor", "given": "Krishan M", "initials": "KM"}, {"family": "Chatrath", "given": "Vandana", "initials": "V"}, {"family": "Boxley", "given": "Sarah G", "initials": "SG"}, {"family": "Nurlin", "given": "Iman", "initials": "I"}, {"family": "Snozzi", "given": "Philippe", "initials": "P"}, {"family": "Demosthenous", "given": "Nestor", "initials": "N"}, {"family": "Belo", "given": "Victoria", "initials": "V"}, {"family": "Chan", "given": "Wai M", "initials": "WM"}, {"family": "Kanaris", "given": "Nicole", "initials": "N"}, {"family": "Kapoor", "given": "Puneet", "initials": "P"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Dermatol Ther", "issn": "1529-8019", "volume": "33", "issue": "4", "pages": "e13597", "issn-l": null}, "abstract": "Strict infection control measures in response to the current COVID-19 pandemic are expected to remain for an extended period. In aesthetic clinics, most procedures are provided on one to one basis by the physician or therapist. In such a scenario, guidelines detailing the infection control measures for aesthetic clinics are of particular importance. An online meeting of an international group of experts in the field of aesthetic medicine, with experience in administration of an aesthetic clinic, was convened. The meeting aimed to provide a set of consensus guidelines to protect clinic staff and patients from SARS-CoV-2 infection. Consensus guidelines for \"preferred practices\" were provided for scheduling of patients, patient evaluation and triaging, and for safety precautions about the different procedures. Procedures were categorized into low-risk, moderate risk, and high-risk based on the likelihood of transmission of SARS-CoV-2 virus from the patient to the treating physician or therapist. While not intended to be complete or exhaustive, these guidelines provide sound infection control measures for aesthetic practices. Since guidelines regarding safety measures and use of PPEs may vary from country to country, the local guidelines should also be followed to prevent COVID-19 infection in aesthetic clinics.", "doi": "10.1111/dth.13597", "pmid": "32415753", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7267045"}], "notes": [], "created": "2020-11-30T09:07:54.552Z", "modified": "2020-11-30T09:07:54.576Z"}, {"entity": "publication", "iuid": "18d87d9d720145059313eeaec0571d68", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18d87d9d720145059313eeaec0571d68.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18d87d9d720145059313eeaec0571d68"}}, "title": "Author Correction: Caring for patients with cancer in the COVID-19 era.", "authors": [{"family": "van de Haar", "given": "Joris", "initials": "J"}, {"family": "Hoes", "given": "Louisa R", "initials": "LR"}, {"family": "Coles", "given": "Charlotte E", "initials": "CE"}, {"family": "Seamon", "given": "Kenneth", "initials": "K"}, {"family": "Fr\u00f6hling", "given": "Stefan", "initials": "S"}, {"family": "J\u00e4ger", "given": "Dirk", "initials": "D"}, {"family": "Valenza", "given": "Franco", "initials": "F"}, {"family": "de Braud", "given": "Filippo", "initials": "F"}, {"family": "De Petris", "given": "Luigi", "initials": "L"}, {"family": "Bergh", "given": "Jonas", "initials": "J"}, {"family": "Ernberg", "given": "Ingemar", "initials": "I"}, {"family": "Besse", "given": "Benjamin", "initials": "B"}, {"family": "Barlesi", "given": "Fabrice", "initials": "F"}, {"family": "Garralda", "given": "Elena", "initials": "E"}, {"family": "Piris-Gim\u00e9nez", "given": "Alejandro", "initials": "A"}, {"family": "Baumann", "given": "Michael", "initials": "M"}, {"family": "Apolone", "given": "Giovanni", "initials": "G"}, {"family": "Soria", "given": "Jean Charles", "initials": "JC"}, {"family": "Tabernero", "given": "Josep", "initials": "J"}, {"family": "Caldas", "given": "Carlos", "initials": "C"}, {"family": "Voest", "given": "Emile E", "initials": "EE"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "volume": "26", "issue": "7", "pages": "1146", "issn-l": "1078-8956"}, "abstract": "An amendment to this paper has been published and can be accessed via a link at the top of the paper.", "doi": "10.1038/s41591-020-0948-7", "pmid": "32494062", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-020-0948-7"}, {"db": "pmc", "key": "PMC7269160"}], "notes": [], "created": "2020-11-25T09:38:02.969Z", "modified": "2020-12-09T10:49:33.755Z"}, {"entity": "publication", "iuid": "34041685e841481e8a7c442c69f3fa9d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/34041685e841481e8a7c442c69f3fa9d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/34041685e841481e8a7c442c69f3fa9d"}}, "title": "Addendum for Euro Surveill. 2020;25(3).", "authors": [{"family": "Eurosurveillance editorial team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "25", "issue": "30", "pages": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.30.2007302", "pmid": "32734858", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7393855"}], "notes": [], "created": "2020-12-07T16:06:30.575Z", "modified": "2020-12-11T12:57:17.295Z"}, {"entity": "publication", "iuid": "5773f521dcfb40b5a8b8f3f58606e0fb", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5773f521dcfb40b5a8b8f3f58606e0fb.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5773f521dcfb40b5a8b8f3f58606e0fb"}}, "title": "A survey on the impact of the COVID-19 pandemic on motility and functional investigations in Europe and considerations for recommencing activities in the early recovery phase.", "authors": [{"family": "Tack", "given": "Jan", "initials": "J"}, {"family": "Schol", "given": "Jolien", "initials": "J"}, {"family": "Geeraerts", "given": "Annelies", "initials": "A"}, {"family": "Huang", "given": "I-Hsuan", "initials": "I"}, {"family": "Mori", "given": "Hideki", "initials": "H"}, {"family": "Scarpellini", "given": "Emidio", "initials": "E"}, {"family": "Sinonquel", "given": "Pieter", "initials": "P"}, {"family": "Carbone", "given": "Florencia", "initials": "F"}, {"family": "Colomier", "given": "Esther", "initials": "E"}, {"family": "Geysen", "given": "Hannelore", "initials": "H"}, {"family": "Jandee", "given": "Sawangpong", "initials": "S"}, {"family": "Moonen", "given": "An", "initials": "A"}, {"family": "Pannemans", "given": "Jasper", "initials": "J"}, {"family": "Timmermans", "given": "Lien", "initials": "L"}, {"family": "Van den Houte", "given": "Karen", "initials": "K"}, {"family": "Verbeure", "given": "Wout", "initials": "W"}, {"family": "Wauters", "given": "Lucas", "initials": "L"}, {"family": "Bisschops", "given": "Raf", "initials": "R"}, {"family": "Hoffman", "given": "Ilse", "initials": "I"}, {"family": "Roelandt", "given": "Philip", "initials": "P"}, {"family": "Rommel", "given": "Nathalie", "initials": "N"}, {"family": "Simren", "given": "Magnus", "initials": "M"}, {"family": "Suzuki", "given": "Hidekazu", "initials": "H"}, {"family": "Tornblom", "given": "Hans", "initials": "H"}, {"family": "Verbeke", "given": "Kristin", "initials": "K"}, {"family": "Vanuytsel", "given": "Tim", "initials": "T"}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Neurogastroenterol Motil", "issn": "1365-2982", "issn-l": null, "volume": "32", "issue": "7", "pages": "e13926"}, "abstract": "The COVID-19 pandemic, declared by WHO on March 13, 2020, had a major global impact on the healthcare system and services. In the acute phase, the presence of the SARS-CoV-2 virus in the aerodigestive tract limited activities in the gastroenterology clinic and procedures to emergencies only. Motility and function testing was interrupted and as we enter the recovery phase, restarting these procedures requires a safety-focused approach with adequate infection prevention for patients and healthcare professionals.\r\n\r\nWe summarized knowledge on the presence of the SARS-CoV-2 virus in the aerodigestive tract and the risk of spread with motility and functional testing. We surveyed 39 European centers documenting how the pandemic affected activities and which measures they are considering for restarting these measurements. We propose recommendations based on current knowledge as applied in our center.\r\n\r\nPositioning of catheters for gastrointestinal motility tests carries a concern for aerosol-borne infection of healthcare workers. The risk is low with breath tests. The surveyed centers stopped almost all motility and function tests from the second half of March. The speed of restarting and the safety measures taken varied highly.\r\n\r\nBased on these findings, we provided recommendations and practical relevant information for motility and function test procedures in the COVID-19 pandemic era, to guarantee a high-quality patient care with adequate infection prevention.", "doi": "10.1111/nmo.13926", "pmid": "32478910", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pmc", "key": "PMC7300498"}], "notes": [], "created": "2020-12-09T10:55:29.360Z", "modified": "2022-11-10T07:48:14.803Z"}, {"entity": "publication", "iuid": "c508cdc6f84d4fdb8086e170d12eb911", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c508cdc6f84d4fdb8086e170d12eb911.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c508cdc6f84d4fdb8086e170d12eb911"}}, "title": "Safe performance of echocardiography during the COVID-19 pandemic: a practical guide.", "authors": [{"family": "Cameli", "given": "Matteo", "initials": "M"}, {"family": "Pastore", "given": "Maria Concetta", "initials": "MC"}, {"family": "Henein", "given": "Michael", "initials": "M"}, {"family": "Aboumarie", "given": "Hatem Soliman", "initials": "HS"}, {"family": "Mandoli", "given": "Giulia Elena", "initials": "GE"}, {"family": "D'Ascenzi", "given": "Flavio", "initials": "F"}, {"family": "Cameli", "given": "Paolo", "initials": "P"}, {"family": "Franchi", "given": "Federico", "initials": "F"}, {"family": "Mondillo", "given": "Sergio", "initials": "S"}, {"family": "Valente", "given": "Serafina", "initials": "S"}], "type": "journal article", "published": "2020-06-30", "journal": {"title": "Rev Cardiovasc Med", "issn": "1530-6550", "volume": "21", "issue": "2", "pages": "217-223", "issn-l": null}, "abstract": "Coronavirus disease-2019 (COVID-19) outbreak has become a worldwide healthcare emergency, with continuously growing number of infected subjects. Considering the easy virus spread through respiratory droplets produced with cough, sneezes or spit or through close contact with infected people or surfaces, healthcare workers are further exposed to COVID-19. Particularly, echocardiography remains an essential diagnostic service which, due to the close contact with patients during the exam, provides echocardiographers high-risk of contagion. Therefore, the common modalities of performing echocardiography should be improved in this scenario, avoiding performing unnecessary exams, using the appropriate personal protective equipment depending on patients' status and location, optimizing time-effectiveness of the echocardiographic study and accurately sanitizing the environment and devices after each exam. This paper aims to provide a simple guide for the clinicians to balance between providing the best care to each patient and protecting themselves and other patients from the spread of the virus. It also proposes the use of the mnemonic PREVENT to resume the crucial indications to be followed for the execution of appropriate echocardiographic examination during the COVID-19 pandemic.", "doi": "10.31083/j.rcm.2020.02.90", "pmid": "32706210", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "1593391605440-950946668"}], "notes": [], "created": "2020-12-07T16:19:38.826Z", "modified": "2020-12-07T16:19:38.852Z"}, {"entity": "publication", "iuid": "c5eeaacb7f194c1090380a80045ce4da", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c5eeaacb7f194c1090380a80045ce4da.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c5eeaacb7f194c1090380a80045ce4da"}}, "title": "Olfactory and Gustatory Outcomes in COVID-19: A Prospective Evaluation in Nonhospitalized Subjects.", "authors": [{"family": "Paderno", "given": "Alberto", "initials": "A"}, {"family": "Mattavelli", "given": "Davide", "initials": "D"}, {"family": "Rampinelli", "given": "Vittorio", "initials": "V"}, {"family": "Grammatica", "given": "Alberto", "initials": "A"}, {"family": "Raffetti", "given": "Elena", "initials": "E"}, {"family": "Tomasoni", "given": "Michele", "initials": "M"}, {"family": "Gualtieri", "given": "Tommaso", "initials": "T"}, {"family": "Taboni", "given": "Stefano", "initials": "S"}, {"family": "Zorzi", "given": "Silvia", "initials": "S"}, {"family": "Del Bon", "given": "Francesca", "initials": "F"}, {"family": "Lombardi", "given": "Davide", "initials": "D"}, {"family": "Deganello", "given": "Alberto", "initials": "A"}, {"family": "Redaelli De Zinis", "given": "Luca Oscar", "initials": "LO"}, {"family": "Schreiber", "given": "Alberto", "initials": "A"}], "type": "journal article", "published": "2020-06-30", "journal": {"title": "Otolaryngol Head Neck Surg", "issn": "1097-6817", "volume": "163", "issue": "6", "pages": "194599820939538", "issn-l": "0194-5998"}, "abstract": "To prospectively assess the rate and timing of recovery of olfactory (OD) and gustatory (GD) dysfunction in patients affected by COVID-19.\n\nCohort study.\n\nPopulation-based evaluation in a COVID-19 high-prevalence region.\n\nWe analyzed the clinical course of OD and GD in a cohort of home-quarantined SARS-CoV-2-positive patients from Northern Italy. Physicians administered a survey-based questionnaire at recruitment (T0). During follow-up, patients responded to online dedicated surveys modulated according to symptoms at T0.\n\nA total of 151 patients completed the follow-up survey. OD and/or GD were observed in 83% and 89% of subjects, respectively. Resolution rates of OD and GD at 30 days from onset were 87% and 82%, respectively. Risk factors for late resolution were grade of dysfunction at onset (total vs partial), gender, and presence of nasal congestion. Three (2%) patients previously reporting complete resolution of symptoms complained of subsequent recurrence of OD and/or GD after a mean of 19 days from resolution of the previous episode.\n\nCOVID-19-related OD and GD had high rate of resolution in the first month from onset of symptoms. However, in 10% to 15% of patients, these symptoms showed only partial improvement after this period.", "doi": "10.1177/0194599820939538", "pmid": "32600175", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7331108"}], "notes": [], "created": "2020-11-18T17:12:18.855Z", "modified": "2021-02-26T08:46:13.493Z"}, {"entity": "publication", "iuid": "d5ef2291db25489db53be5bf008166de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d5ef2291db25489db53be5bf008166de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d5ef2291db25489db53be5bf008166de"}}, "title": "The cholinergic anti-inflammatory pathway alleviates acute lung injury.", "authors": [{"family": "Andersson", "given": "Ulf", "initials": "U"}], "type": "letter", "published": "2020-06-29", "journal": {"title": "Mol Med", "issn": "1528-3658", "volume": "26", "issue": "1", "pages": "64", "issn-l": "1076-1551"}, "abstract": "The ubiquiotous nuclear protein HMGB1 is extracellularly released by dying cells or activated innate immunity cells to promote inflammation. Extracellular HMGB1 plays a prominent role in the pathogenesis of acute lung injury of infectious as well as sterile origin including hyperoxia. Excessive amounts of systemic HMGB1 and HMGB1-partner molecule complexes can be retained in the pulmonary circulation indicated by a substantial reduction of HMGB1 plasma levels in arterial versus venous blood. The cholinergic antiinflammatory mechanism ameliorates pulmonary inflammation by inhibiting HMGB1 release and HMGB1 receptor expression. This comprehension was recently reinforced by results reported in Molecular Medicine by Sitapara and coworkers demonstrating that administration of an \u03b17 nicotinic acetylcholine receptor agonist attenuated hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation. Activating the cholinergic antiinflammatory path might be considered to alleviate severe COVID-19 with or without concurrent oxygen-induced lung injury.", "doi": "10.1186/s10020-020-00184-0", "pmid": "32600316", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s10020-020-00184-0"}, {"db": "pmc", "key": "PMC7322708"}], "notes": [], "created": "2020-12-08T15:25:40.235Z", "modified": "2020-12-08T15:25:40.247Z"}, {"entity": "publication", "iuid": "0274d5946ea445bd80c6f37ead8dfe5e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0274d5946ea445bd80c6f37ead8dfe5e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0274d5946ea445bd80c6f37ead8dfe5e"}}, "title": "Coronavirus Disease Pandemic (COVID-19): Challenges and a Global Perspective.", "authors": [{"family": "Malik", "given": "Yashpal Singh", "initials": "YS"}, {"family": "Kumar", "given": "Naveen", "initials": "N"}, {"family": "Sircar", "given": "Shubhankar", "initials": "S"}, {"family": "Kaushik", "given": "Rahul", "initials": "R"}, {"family": "Bhat", "given": "Sudipta", "initials": "S"}, {"family": "Dhama", "given": "Kuldeep", "initials": "K"}, {"family": "Gupta", "given": "Parakriti", "initials": "P"}, {"family": "Goyal", "given": "Kapil", "initials": "K"}, {"family": "Singh", "given": "Mini P", "initials": "MP"}, {"family": "Ghoshal", "given": "Ujjala", "initials": "U"}, {"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME"}, {"family": "O R", "given": "VinodhKumar", "initials": "V"}, {"family": "Yatoo", "given": "Mohd Iqbal", "initials": "MI"}, {"family": "Tiwari", "given": "Ruchi", "initials": "R"}, {"family": "Pathak", "given": "Mamta", "initials": "M"}, {"family": "Patel", "given": "Shailesh Kumar", "initials": "SK"}, {"family": "Sah", "given": "Ranjit", "initials": "R"}, {"family": "Rodriguez-Morales", "given": "Alfonso J", "initials": "AJ"}, {"family": "Ganesh", "given": "Balasubramanian", "initials": "B"}, {"family": "Kumar", "given": "Prashant", "initials": "P"}, {"family": "Singh", "given": "Raj Kumar", "initials": "RK"}], "type": "journal article", "published": "2020-06-28", "journal": {"title": "Pathogens", "issn": "2076-0817", "volume": "9", "issue": "7", "issn-l": "2076-0817"}, "abstract": "The technology-driven world of the 21 st century is currently confronted with a major threat to humankind, represented by the coronavirus disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome, coronavirus-2 (SARS-CoV-2). As of now, COVID-19 has affected more than 6 million confirmed cases and took 0.39 million human lives. SARS-CoV-2 spreads much faster than its two ancestors, SARS-CoV and Middle East respiratory syndrome-CoV (MERS-CoV), but has low fatality rates. Our analyses speculate that the efficient replication and transmission of SARS-CoV-2 might be due to the high-density basic amino acid residues, preferably positioned in close proximity at both the furin-like cleavage sites (S1/S2 and S2') within the spike protein. Given the high genomic similarities of SARS-CoV-2 to bat SARS-like CoVs, it is likely that bats serve as a reservoir host for its progenitor. Women and children are less susceptible to SARS-CoV-2 infection, while the elderly and people with comorbidities are more prone to serious clinical outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. The cohesive approach amongst researchers across the globe has delivered high-end viral diagnostics. However, home-based point-of-care diagnostics are still under development, which may prove transformative in current COVID-19 pandemic containment. Similarly, vaccines and therapeutics against COVID-19 are currently in the pipeline for clinical trials. In this review, we discuss the noteworthy advancements, focusing on the etiological viral agent, comparative genomic analysis, population susceptibility, disease epidemiology and diagnosis, animal reservoirs, laboratory animal models, disease transmission, therapeutics, vaccine challenges, and disease mitigation measures.", "doi": "10.3390/pathogens9070519", "pmid": "32605194", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "pathogens9070519"}, {"db": "pmc", "key": "PMC7400054"}], "notes": [], "created": "2020-11-19T14:23:51.630Z", "modified": "2020-11-30T08:54:51.546Z"}, {"entity": "publication", "iuid": "e0c42706c478434a9a7dbbba2bba0fc5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e0c42706c478434a9a7dbbba2bba0fc5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e0c42706c478434a9a7dbbba2bba0fc5"}}, "title": "Overcoming fragmentation of health research in Europe: lessons from COVID-19.", "authors": [{"family": "Sipido", "given": "Karin R", "initials": "KR"}, {"family": "Anto\u00f1anzas", "given": "Fernando", "initials": "F"}, {"family": "Celis", "given": "Julio", "initials": "J"}, {"family": "Degos", "given": "Laurent", "initials": "L"}, {"family": "Frackowiak", "given": "Richard", "initials": "R"}, {"family": "Fuster", "given": "Valentin", "initials": "V"}, {"family": "Ganten", "given": "Detlev", "initials": "D"}, {"family": "Gay", "given": "Steffen", "initials": "S"}, {"family": "Hofstraat", "given": "Hans", "initials": "H"}, {"family": "Holgate", "given": "Stephen T", "initials": "ST"}, {"family": "Krestin", "given": "Gabriel", "initials": "G"}, {"family": "Manns", "given": "Michael", "initials": "M"}, {"family": "Meunier", "given": "Francoise", "initials": "F"}, {"family": "Oertel", "given": "Wolfgang", "initials": "W"}, {"family": "Palkonen", "given": "Susanna", "initials": "S"}, {"family": "Pavalkis", "given": "Dainius", "initials": "D"}, {"family": "R\u00fcbsamen-Schaeff", "given": "Helga", "initials": "H"}, {"family": "Smith", "given": "Ulf", "initials": "U"}, {"family": "Stallknecht", "given": "Bente Merete", "initials": "BM"}, {"family": "Zima", "given": "Tom\u00e1\u0161", "initials": "T"}], "type": "letter", "published": "2020-06-27", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "395", "issue": "10242", "pages": "1970-1971", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)31411-2", "pmid": "32559417", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31411-2"}], "notes": [], "created": "2020-12-09T07:45:28.016Z", "modified": "2020-12-09T07:45:28.029Z"}, {"entity": "publication", "iuid": "72abfafc02044690936b841354712977", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/72abfafc02044690936b841354712977.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/72abfafc02044690936b841354712977"}}, "title": "Gendered effects of school closures during the COVID-19 pandemic.", "authors": [{"family": "Burzynska", "given": "Katarzyna", "initials": "K"}, {"family": "Contreras", "given": "Gabriela", "initials": "G"}], "type": "letter", "published": "2020-06-27", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "395", "issue": "10242", "pages": "1968", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)31377-5", "pmid": "32539938", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31377-5"}, {"db": "pmc", "key": "PMC7292576"}], "notes": [], "created": "2020-12-09T07:56:28.304Z", "modified": "2020-12-09T07:56:28.314Z"}, {"entity": "publication", "iuid": "2850cf94d5cb4ab8b9a654e4694fcd05", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2850cf94d5cb4ab8b9a654e4694fcd05.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2850cf94d5cb4ab8b9a654e4694fcd05"}}, "title": "Health equity and COVID-19: global perspectives.", "authors": [{"family": "Shadmi", "given": "Efrat", "initials": "E"}, {"family": "Chen", "given": "Yingyao", "initials": "Y"}, {"family": "Dourado", "given": "In\u00eas", "initials": "I"}, {"family": "Faran-Perach", "given": "Inbal", "initials": "I"}, {"family": "Furler", "given": "John", "initials": "J"}, {"family": "Hangoma", "given": "Peter", "initials": "P"}, {"family": "Hanvoravongchai", "given": "Piya", "initials": "P"}, {"family": "Obando", "given": "Claudia", "initials": "C"}, {"family": "Petrosyan", "given": "Varduhi", "initials": "V"}, {"family": "Rao", "given": "Krishna D", "initials": "KD"}, {"family": "Ruano", "given": "Ana Lorena", "initials": "AL"}, {"family": "Shi", "given": "Leiyu", "initials": "L"}, {"family": "de Souza", "given": "Luis Eugenio", "initials": "LE"}, {"family": "Spitzer-Shohat", "given": "Sivan", "initials": "S"}, {"family": "Sturgiss", "given": "Elizabeth", "initials": "E"}, {"family": "Suphanchaimat", "given": "Rapeepong", "initials": "R"}, {"family": "Uribe", "given": "Manuela Villar", "initials": "MV"}, {"family": "Willems", "given": "Sara", "initials": "S"}], "type": "letter", "published": "2020-06-26", "journal": {"title": "Int J Equity Health", "issn": "1475-9276", "volume": "19", "issue": "1", "pages": "104", "issn-l": null}, "abstract": "The COVID-19 is disproportionally affecting the poor, minorities and a broad range of vulnerable populations, due to its inequitable spread in areas of dense population and limited mitigation capacity due to high prevalence of chronic conditions or poor access to high quality public health and medical care. Moreover, the collateral effects of the pandemic due to the global economic downturn, and social isolation and movement restriction measures, are unequally affecting those in the lowest power strata of societies. To address the challenges to health equity and describe some of the approaches taken by governments and local organizations, we have compiled 13 country case studies from various regions around the world: China, Brazil, Thailand, Sub Saharan Africa, Nicaragua, Armenia, India, Guatemala, United States of America (USA), Israel, Australia, Colombia, and Belgium. This compilation is by no-means representative or all inclusive, and we encourage researchers to continue advancing global knowledge on COVID-19 health equity related issues, through rigorous research and generation of a strong evidence base of new empirical studies in this field.", "doi": "10.1186/s12939-020-01218-z", "pmid": "32586388", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12939-020-01218-z"}, {"db": "pmc", "key": "PMC7316580"}], "notes": [], "created": "2020-12-08T15:49:56.457Z", "modified": "2020-12-08T15:49:56.479Z"}, {"entity": "publication", "iuid": "721dbc34e48a45b0a8d08caa5f332526", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/721dbc34e48a45b0a8d08caa5f332526.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/721dbc34e48a45b0a8d08caa5f332526"}}, "title": "Are official confirmed cases and fatalities counts good enough to study the COVID-19 pandemic dynamics? A critical assessment through the case of Italy.", "authors": [{"family": "Bartoszek", "given": "Krzysztof", "initials": "K"}, {"family": "Guidotti", "given": "Emanuele", "initials": "E"}, {"family": "Iacus", "given": "Stefano Maria", "initials": "SM"}, {"family": "Okr\u00f3j", "given": "Marcin", "initials": "M"}], "type": "journal article", "published": "2020-06-26", "journal": {"title": "Nonlinear Dyn", "issn": "0924-090X", "volume": null, "issue": null, "pages": "1-29", "issn-l": null}, "abstract": "As the COVID-19 outbreak is developing the two most frequently reported statistics seem to be the raw confirmed case and case fatalities counts. Focusing on Italy, one of the hardest hit countries, we look at how these two values could be put in perspective to reflect the dynamics of the virus spread. In particular, we find that merely considering the confirmed case counts would be very misleading. The number of daily tests grows, while the daily fraction of confirmed cases to total tests has a change point. It (depending on region) generally increases with strong fluctuations till (around, depending on region) 15-22 March and then decreases linearly after. Combined with the increasing trend of daily performed tests, the raw confirmed case counts are not representative of the situation and are confounded with the sampling effort. This we observe when regressing on time the logged fraction of positive tests and for comparison the logged raw confirmed count. Hence, calibrating model parameters for this virus's dynamics should not be done based only on confirmed case counts (without rescaling by the number of tests), but take also fatalities and hospitalization count under consideration as variables not prone to be distorted by testing efforts. Furthermore, reporting statistics on the national level does not say much about the dynamics of the disease, which are taking place at the regional level. These findings are based on the official data of total death counts up to 15 April 2020 released by ISTAT and up to 10 May 2020 for the number of cases. In this work, we do not fit models but we rather investigate whether this task is possible at all. This work also informs about a new tool to collect and harmonize official statistics coming from different sources in the form of a package for the R statistical environment and presents the \"COVID-19 Data Hub.\"", "doi": "10.1007/s11071-020-05761-w", "pmid": "32836808", "labels": {"Type: Other": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "5761"}, {"db": "pmc", "key": "PMC7319224"}], "notes": [], "created": "2020-12-07T10:39:54.736Z", "modified": "2021-02-26T08:46:13.245Z"}, {"entity": "publication", "iuid": "9311ddb1127943c3925f38dd3fc1584b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9311ddb1127943c3925f38dd3fc1584b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9311ddb1127943c3925f38dd3fc1584b"}}, "title": "SARS-COV-2 and biomimetics: What saves the planet will save our health.", "authors": [{"family": "Stenvinkel", "given": "P", "initials": "P"}, {"family": "Painer", "given": "J", "initials": "J"}, {"family": "Shiels", "given": "P G", "initials": "PG"}, {"family": "Bansal", "given": "A", "initials": "A"}, {"family": "Fereidouni", "given": "S", "initials": "S"}, {"family": "Natterson-Horowitz", "given": "B", "initials": "B"}, {"family": "Johnson", "given": "R J", "initials": "RJ"}, {"family": "Miranda", "given": "J J", "initials": "JJ"}], "type": "journal article", "published": "2020-06-24", "journal": {"title": "J Intern Med", "issn": "1365-2796", "volume": null, "issue": null, "issn-l": null}, "abstract": null, "doi": "10.1111/joim.13128", "pmid": "32583447", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7361468"}], "notes": [], "created": "2020-12-08T15:53:33.978Z", "modified": "2020-12-08T15:53:33.989Z"}, {"entity": "publication", "iuid": "abda8a50c38944a1a031a24d005c13cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/abda8a50c38944a1a031a24d005c13cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/abda8a50c38944a1a031a24d005c13cc"}}, "title": "Modeling quarantine during epidemics and mass-testing using drones.", "authors": [{"family": "Sedov", "given": "Leonid", "initials": "L"}, {"family": "Krasnochub", "given": "Alexander", "initials": "A"}, {"family": "Polishchuk", "given": "Valentin", "initials": "V"}], "type": "journal article", "published": "2020-06-24", "journal": {"title": "PLoS One", "issn": "1932-6203", "volume": "15", "issue": "6", "pages": "e0235307", "issn-l": "1932-6203"}, "abstract": "We extend the classical SIR epidemic spread model by introducing the \"quarantined\" compartment. We solve (numerically) the differential equations that govern the extended model and quantify how quarantining \"flattens the curve\" for the proportion of infected population over time. Furthermore, we explore the potential of using drones to deliver tests, enabling mass-testing for the infection; we give a method to estimate the drone fleet needed to deliver the tests in a metropolitan area. Application of our models to COVID-19 spread in Sweden shows how the proposed methods could substantially decrease the peak number of infected people, almost without increasing the duration of the epidemic.", "doi": "10.1371/journal.pone.0235307", "pmid": "32579590", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "PONE-D-20-11647"}, {"db": "pmc", "key": "PMC7314055"}], "notes": [], "created": "2020-12-08T15:54:48.116Z", "modified": "2020-12-08T15:54:48.127Z"}, {"entity": "publication", "iuid": "eb49878592064e0ab759503cd2c0537d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eb49878592064e0ab759503cd2c0537d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eb49878592064e0ab759503cd2c0537d"}}, "title": "Simulation-based skills training in non-performing orthopedic surgeons: skills acquisition, motivation, and flow during the COVID-19 pandemic.", "authors": [{"family": "Hedman", "given": "Leif Rune", "initials": "LR"}, {"family": "Fell\u00e4nder-Tsai", "given": "Li", "initials": "L"}], "type": "journal article", "published": "2020-06-23", "journal": {"title": "Acta Orthop", "issn": "1745-3682", "volume": null, "issue": null, "pages": "1-5", "issn-l": null}, "abstract": null, "doi": "10.1080/17453674.2020.1781413", "pmid": "32573303", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-08T16:24:35.275Z", "modified": "2020-12-08T16:24:35.296Z"}, {"entity": "publication", "iuid": "9dfda2d805a9485fa5c8459fbd46db7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9dfda2d805a9485fa5c8459fbd46db7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9dfda2d805a9485fa5c8459fbd46db7a"}}, "title": "Re-positive Cases of Nucleic Acid Tests in Discharged Patients With COVID-19: A Follow-Up Study.", "authors": [{"family": "Qiao", "given": "Xi-Min", "initials": "XM"}, {"family": "Xu", "given": "Xiao-Feng", "initials": "XF"}, {"family": "Zi", "given": "Hao", "initials": "H"}, {"family": "Liu", "given": "Guo-Xiong", "initials": "GX"}, {"family": "Li", "given": "Bing-Hui", "initials": "BH"}, {"family": "Du", "given": "Xiang", "initials": "X"}, {"family": "Tian", "given": "Zhi-Hai", "initials": "ZH"}, {"family": "Liu", "given": "Xiao-Ying", "initials": "XY"}, {"family": "Luo", "given": "Li-Sha", "initials": "LS"}, {"family": "Wang", "given": "Xiao", "initials": "X"}], "type": "journal article", "published": "2020-06-23", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "7", "issue": null, "pages": "349", "issn-l": null}, "abstract": "Background: The frequent emergence of the re-positive patients with COVID-19 is a potential threat worldwide. This study aimed to describe data from admission to follow-up for patients with COVID-19 and analyze the possible causes for re-positive nucleic acid tests to provide more scientific basis for reducing the numbers of re-positive patients after discharge. Methods: We retrospectively recorded 15 patients with COVID-19 admitted to the Xianyang Central Hospital, China. The baseline, exposure histories, clinical syndromes, laboratory characteristics, nucleic acid, and follow-up tests were analyzed, and the radiological characteristics of re-positive patient at different periods were compared. Results: Eight (53.33%) patients had the history of travel to Wuhan, four (26.67%) patients had close contact with confirmed patients, and one (6.67%) patient had close contact with suspected patients. After treatment, all patients had two consecutively negative nucleic acid tests and were discharged from hospital. All patients were followed up for more than 14 days, and the average time from discharge to the first follow-up was 14.67 \u00b1 3.31 days (from 9 to 22 days). Most patients showed no clinical symptoms and negative nucleic acid tests, while one patient had an itchy throat, her CT scan showed a light density shadow in the right lower lobe of the lung, and the nucleic acid was once again positive. The second follow-up of the other 14 patients (except the re-positive one) was conducted 20.80 \u00b1 7.78 days (from 13 to 30 days) after discharge, and all of them had negative nucleic acid tests. The positive patient was immediately readmitted and received a new round of treatment. Her family members and colleagues remained healthy until now. Conclusions: The quality of nucleic acid testing reagents should be enhanced, and the training of nucleic acid sampling operators should be strengthened to reduce the false-negative results in the nucleic acid of SARS-CoV-2; the clinical specimens of throat and nasopharynx swabs can be collected at the same time; IgM- and IgG-specific antibodies of SARS-CoV-2 should be carried out for discharged patients; the radiological characteristics should be evaluated strictly; and the discharge standard can be specified according to the baseline and severity of disease of patients.", "doi": "10.3389/fmed.2020.00349", "pmid": "32656223", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "All data provided in the article", "description": null}], "notes": [], "created": "2020-12-08T14:14:57.177Z", "modified": "2021-02-26T08:45:48.527Z"}, {"entity": "publication", "iuid": "9428858ffe57443e8565e9bc0c31a4de", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9428858ffe57443e8565e9bc0c31a4de.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9428858ffe57443e8565e9bc0c31a4de"}}, "title": "Maximizing Safety in the Conduct of Alzheimer's Disease Fluid Biomarker Research in the Era of COVID-19.", "authors": [{"family": "Schindler", "given": "Suzanne E", "initials": "SE"}, {"family": "Jicha", "given": "Gregory A", "initials": "GA"}, {"family": "Nelson", "given": "Peter T", "initials": "PT"}, {"family": "Keene", "given": "C Dirk", "initials": "CD"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Molinuevo", "given": "Jos\u00e9 Luis", "initials": "JL"}, {"family": "Masters", "given": "Colin L", "initials": "CL"}, {"family": "Hansson", "given": "Oskar", "initials": "O"}, {"family": "Teunissen", "given": "Charlotte E", "initials": "CE"}, {"family": "Galasko", "given": "Douglas", "initials": "D"}, {"family": "Shaw", "given": "Leslie M", "initials": "LM"}, {"family": "Levey", "given": "Allan I", "initials": "AI"}, {"family": "Silverberg", "given": "Nina", "initials": "N"}], "type": "letter", "published": "2020-06-23", "journal": {"title": "J Alzheimers Dis", "issn": "1875-8908", "volume": "76", "issue": "1", "pages": "27-31", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic led to an abrupt halt of many Alzheimer's disease (AD) research studies at sites spanning the world. This is especially true for studies requiring in-person contact, such as studies collecting biofluids. Since COVID-19 is likely to remain a threat for an extended period, the resumption of fluid biomarker studies requires the development and implementation of procedures that minimize the risk of in-person visits to participants, staff, and individuals handling the biofluid samples. Some issues to consider include structuring the visit workflow to minimize contacts and promote social distancing; screening and/or testing participants and staff for COVID-19; wearing masks and performing hand hygiene; and precautions for handling, storing, and analyzing biofluids. AD fluid biomarker research remains a vitally important public health priority and resuming studies requires appropriate safety procedures to protect research participants and staff.", "doi": "10.3233/JAD-200684", "pmid": "32568212", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "JAD200684"}], "notes": [], "created": "2020-12-08T16:29:25.802Z", "modified": "2020-12-08T16:29:25.825Z"}, {"entity": "publication", "iuid": "26a3f95ac88b41c4a35b29165a82f0e7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26a3f95ac88b41c4a35b29165a82f0e7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26a3f95ac88b41c4a35b29165a82f0e7"}}, "title": "Does a surgical helmet provide protection against aerosol transmitted disease?", "authors": [{"family": "Temmesfeld", "given": "Max Joachim", "initials": "MJ"}, {"family": "Jakobsen", "given": "Rune Bruhn", "initials": "RB"}, {"family": "Grant", "given": "Peter", "initials": "P"}], "type": "journal article", "published": "2020-06-23", "journal": {"title": "Acta Orthop", "issn": "1745-3682", "volume": null, "issue": null, "pages": "1-5", "issn-l": null}, "abstract": "Background and purpose - The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to a global shortage of personal protective equipment (PPE). Various alternatives to ordinary PPE have been suggested to reduce transmission, which is primarily through droplets and aerosols. For many years orthopedic surgeons have been using surgical helmets as personal protection against blood-borne pathogens during arthroplasty surgery. We have investigated the possibility of using the Stryker Flyte surgical helmet as a respiratory protective device against airborne- and droplet-transmitted disease, since the helmet shares many features with powered air-purifying respirators.Materials and methods - Using an aerosol particle generator, we determined the filtration capacity of the Stryker Flyte helmet by placing particle counters measuring the concentrations of 0.3, 0.5, and 5 \u00b5m particles inside and outside of the helmet.Results - We found that the helmet has insufficient capacity for filtrating aerosol particles, and, for 0.3 \u00b5m sized particles, we even recorded an accumulation of particles inside the helmet.Interpretation - We conclude that the Stryker Flyte surgical helmet should not be used as a respiratory protective device when there is a risk for exposure to aerosol containing SARS-CoV-2, the virus causing COVID-19, in accordance with the recommendation from the manufacturer.", "doi": "10.1080/17453674.2020.1771525", "pmid": "32573285", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-08T16:25:11.699Z", "modified": "2020-12-08T16:25:11.711Z"}, {"entity": "publication", "iuid": "2370821b31b14cf8a22f331c2d6bbe77", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2370821b31b14cf8a22f331c2d6bbe77.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2370821b31b14cf8a22f331c2d6bbe77"}}, "title": "COVID-19 IDD: A global survey exploring the impact of COVID-19 on individuals with intellectual and developmental disabilities and their caregivers.", "authors": [{"family": "Linehan", "given": "Christine", "initials": "C"}, {"family": "Araten-Bergam", "given": "Tal", "initials": "T"}, {"family": "Beadle-Brown", "given": "Julie", "initials": "J"}, {"family": "Bigby", "given": "Christine", "initials": "C"}, {"family": "Birkbeck", "given": "Gail", "initials": "G"}, {"family": "Bradley", "given": "Valerie", "initials": "V"}, {"family": "Brown", "given": "Michael", "initials": "M"}, {"family": "Bredewold", "given": "Femmianne", "initials": "F"}, {"family": "Chirwa", "given": "Masauso", "initials": "M"}, {"family": "Kanova", "given": "Sarka", "initials": "S"}, {"family": "Kroll", "given": "Thilo", "initials": "T"}, {"family": "MacLachlan", "given": "Mac", "initials": "M"}, {"family": "Narayan", "given": "Jayanthi", "initials": "J"}, {"family": "Nearchou", "given": "Finiki", "initials": "F"}, {"family": "Nolan", "given": "Adam", "initials": "A"}, {"family": "O'Donovan", "given": "Mary-Ann", "initials": "MA"}, {"family": "Santos", "given": "Flavia H", "initials": "FH"}, {"family": "Siska", "given": "Jan", "initials": "J"}, {"family": "Tideman", "given": "Magnus", "initials": "M"}, {"family": "Tossebro", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2020-06-23", "journal": {"title": "HRB Open Res", "issn": "2515-4826", "volume": "3", "issue": null, "pages": "39", "issn-l": null}, "abstract": "Background: This protocol outlines research to explore the impact of coronavirus disease 2019 (COVID-19) on individuals who have intellectual and developmental disabilities and their caregivers. Evidence suggests that people with intellectual and developmental disabilities experience disparities in healthcare access and utilisation. This disparity was evident early in the pandemic when discussions arose regarding the potential exclusion of this population to critical care. Methods: An anonymous online survey will be conducted with caregivers, both family members and paid staff, to explore the impact of COVID-19 on this population in terms of demographics, living arrangements, access to services, the impact of social distancing, and also carer wellbeing. The survey will be developed by the research team, many of whom are experts in intellectual disability within their own jurisdictions. Using back-translation our team will translate the survey for distribution in 16 countries worldwide for international comparison. The survey team have extensive personal and professional networks in intellectual disability and will promote the survey widely on social media with the support of local disability and advocacy agencies. Statistical descriptive and comparative analyses will be conducted. Ethical approval has been obtained for this study from University College Dublin's Human Research Ethics Committee (HS-20-28-Linehan). Dissemination: Study findings will be prepared in a number of formats in order to meet the needs of different audiences. Outputs will include academic papers, lessons learned paper, practice guidelines, reports, infographics and video content. These outputs will be directed to families, frontline and management delivering disability services, national-level policy makers, healthcare quality and delivery authorities, national pandemic organisations and international bodies.", "doi": "10.12688/hrbopenres.13077.1", "pmid": "33392440", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7745183"}], "notes": [], "created": "2021-01-05T15:17:20.252Z", "modified": "2021-02-26T08:46:59.862Z"}, {"entity": "publication", "iuid": "0ddad22d61894a518568a0db3ecbf194", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ddad22d61894a518568a0db3ecbf194.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ddad22d61894a518568a0db3ecbf194"}}, "title": "Creating misinformation: how a headline in The BMJ about covid-19 spread virally.", "authors": [{"family": "Winters", "given": "Maike", "initials": "M"}, {"family": "Oppenheim", "given": "Ben", "initials": "B"}, {"family": "Pick", "given": "Jonas", "initials": "J"}, {"family": "Nordenstedt", "given": "Helena", "initials": "H"}], "type": "letter", "published": "2020-06-18", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "369", "issue": null, "pages": "m2384", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m2384", "pmid": "32554782", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-09T07:46:47.709Z", "modified": "2020-12-09T07:46:47.718Z"}, {"entity": "publication", "iuid": "4c3bed3cd46f43f491164d00cd961e01", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4c3bed3cd46f43f491164d00cd961e01.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4c3bed3cd46f43f491164d00cd961e01"}}, "title": "The Coronavirus Pandemic and Lessons Learned in Preschools in Norway, Sweden and the United States: OMEP Policy Forum.", "authors": [{"family": "Pramling Samuelsson", "given": "Ingrid", "initials": "I"}, {"family": "Wagner", "given": "Judith T", "initials": "JT"}, {"family": "Eriksen \u00d8degaard", "given": "Elin", "initials": "E"}], "type": "journal article", "published": "2020-06-17", "journal": {"title": "Int J Early Child", "issn": "0020-7187", "volume": null, "issue": null, "pages": "1-16", "issn-l": null}, "abstract": "The novel coronavirus, also known as COVID-19, has moved rapidly across the world in 2020. This article reports on the recent consequences of the pandemic for early childhood education in Sweden, Norway, and the United States. The authors illustrate the effects of the pandemic on preschools in their countries, against a backdrop of frequent changes in infection and mortality rates, epidemiological understandings, government strategies, and mitigation strategies regarding preschool closures. Teachers report their experiences and actions in specific early childhood education settings, across the three national contexts. These experiential snapshots identify program priorities, parents' and children's reactions, and the commitment and concerns of teachers. The conversations reveal culturally situated similarities of early childhood educational practices but also differences across contexts. Teachers report on the challenges of their experiences but also benefits for their practice and how they engage with children and their families. Ideas about future preparedness for such pandemics are also discussed.", "doi": "10.1007/s13158-020-00267-3", "pmid": "32836368", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "267"}, {"db": "pmc", "key": "PMC7299556"}], "notes": [], "created": "2020-12-07T11:39:17.525Z", "modified": "2020-12-07T11:39:17.551Z"}, {"entity": "publication", "iuid": "49b89c9d3b9b4722899f24bbfcfa22fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/49b89c9d3b9b4722899f24bbfcfa22fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/49b89c9d3b9b4722899f24bbfcfa22fa"}}, "title": "Strategy for Disease Diagnosis, Progression Prediction, Risk Group Stratification and Treatment-Case of COVID-19.", "authors": [{"family": "Vihinen", "given": "Mauno", "initials": "M"}], "type": "journal article", "published": "2020-06-16", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "7", "issue": null, "pages": "294", "issn-l": null}, "abstract": "A novel strategy is presented for reliable diagnosis and progression prediction of diseases with special attention to COVID-19 pandemic. A plan is presented for how the model can be implemented worldwide in healthcare and how novel treatments and targets can be detected. The idea is based on poikilosis, pervasive heterogeneity, and variation at all levels, systems, and mechanisms. Poikilosis in diseases can be taken into account in pathogenicity model, which is based on distribution of three independent condition measures-extent, modulation, and severity. Pathogenicity model is a population or cohort-based description of disease components. Evidence-based thresholds can be applied to the pathogenicity model and used for diagnosis as well as for early detection of patients in risk of developing the most severe forms of the disease. Analysis of patients with differential course of disease can help in detecting biomarkers of diagnostic and prognostic significance. A practical and feasible plan is presented how the concepts can be implemented in practice. Collaboration of many actors, including the World Health Organization and national health authorities, will be essential for success.", "doi": "10.3389/fmed.2020.00294", "pmid": "32613004", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7308420"}], "notes": [], "created": "2020-12-08T15:19:35.899Z", "modified": "2020-12-08T15:19:35.908Z"}, {"entity": "publication", "iuid": "8a9bb861986d4d25b069df3861b0bc3d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a9bb861986d4d25b069df3861b0bc3d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a9bb861986d4d25b069df3861b0bc3d"}}, "title": "Ethical Criteria for the Admission and Management of Patients in the ICU Under Conditions of Limited Medical Resources: A Shared International Proposal in View of the COVID-19 Pandemic.", "authors": [{"family": "Tambone", "given": "Vittoradolfo", "initials": "V"}, {"family": "Boudreau", "given": "Donald", "initials": "D"}, {"family": "Ciccozzi", "given": "Massimo", "initials": "M"}, {"family": "Sanders", "given": "Karen", "initials": "K"}, {"family": "Campanozzi", "given": "Laura Leondina", "initials": "LL"}, {"family": "Wathuta", "given": "Jane", "initials": "J"}, {"family": "Violante", "given": "Luciano", "initials": "L"}, {"family": "Cauda", "given": "Roberto", "initials": "R"}, {"family": "Petrini", "given": "Carlo", "initials": "C"}, {"family": "Abbate", "given": "Antonio", "initials": "A"}, {"family": "Alloni", "given": "Rossana", "initials": "R"}, {"family": "Argemi", "given": "Josepmaria", "initials": "J"}, {"family": "Argem\u00ed Renom", "given": "Josep", "initials": "J"}, {"family": "De Benedictis", "given": "Anna", "initials": "A"}, {"family": "Galerneau", "given": "France", "initials": "F"}, {"family": "Garc\u00eda-S\u00e1nchez", "given": "Emilio", "initials": "E"}, {"family": "Ghilardi", "given": "Giampaolo", "initials": "G"}, {"family": "Hafler", "given": "Janet Palmer", "initials": "JP"}, {"family": "Linden", "given": "Magdalena", "initials": "M"}, {"family": "Marcos", "given": "Alfredo", "initials": "A"}, {"family": "Onetti Muda", "given": "Andrea", "initials": "A"}, {"family": "Pandolfi", "given": "Marco", "initials": "M"}, {"family": "Pelaccia", "given": "Thierry", "initials": "T"}, {"family": "Picozzi", "given": "Mario", "initials": "M"}, {"family": "Revello", "given": "Ruben Oscar", "initials": "RO"}, {"family": "Ricci", "given": "Giovanna", "initials": "G"}, {"family": "Rohrbaugh", "given": "Robert", "initials": "R"}, {"family": "Rossi", "given": "Patrizio", "initials": "P"}, {"family": "Sirignano", "given": "Ascanio", "initials": "A"}, {"family": "Spagnolo", "given": "Antonio Gioacchino", "initials": "AG"}, {"family": "Stammers", "given": "Trevor", "initials": "T"}, {"family": "Vel\u00e1zquez", "given": "Lourdes", "initials": "L"}, {"family": "Agazzi", "given": "Evandro", "initials": "E"}, {"family": "Mercurio", "given": "Mark", "initials": "M"}], "type": "journal article", "published": "2020-06-16", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "284", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2020.00284", "pmid": "32612972", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7308475"}], "notes": [], "created": "2020-12-08T15:20:15.113Z", "modified": "2020-12-08T15:20:15.122Z"}, {"entity": "publication", "iuid": "6e1934b517a94c6b8dad3b638f75caca", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e1934b517a94c6b8dad3b638f75caca.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e1934b517a94c6b8dad3b638f75caca"}}, "title": "Evaluation of the English Version of the Fear of COVID-19 Scale and Its Relationship with Behavior Change and Political Beliefs.", "authors": [{"family": "Winter", "given": "Taylor", "initials": "T"}, {"family": "Riordan", "given": "Benjamin C", "initials": "BC"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Mason", "given": "Andre", "initials": "A"}, {"family": "Poulgrain", "given": "John W", "initials": "JW"}, {"family": "Scarf", "given": "Damian", "initials": "D"}], "type": "journal article", "published": "2020-06-15", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "volume": null, "issue": null, "pages": "1-11", "issn-l": null}, "abstract": "The COVID-19 pandemic has many individuals around the world fearing for their lives. The constant news coverage, rapid transmission, and relatively high mortality rate, make fearfulness a natural response. To assess the fear of COVID-19, the Fear of COVID-19 Scale (FCV-19S) was developed. The primary aim of the present study was to conduct the first psychometric assessment and validation of the English version of the FCV-19S. Two samples were collected in New Zealand. Sample 1 comprised 1624 participants of which 1397 completed all questions and were used in the analyses. Sample 2 comprised 1111 participants of which 1023 completed all questions and were used in the analyses. Several psychometric tests were conducted to ascertain the scale's reliability and validity. Across both samples, the FCV-19S had high internal consistency. Consistent with the earlier validation studies, the FCV-19S displayed a moderately strong relationship with the perceived infectability and germ aversion subscales of the perceived vulnerability to disease scale (PVDS). Furthermore, FCV-19S scores were negatively correlated with the Warwick-Edinburgh Mental Wellbeing Scale (WEMWBS) scores. With respect to the motivating role of fear, there was a significant relationship between FCV-19S scores and adherence to the lockdown rules that were implemented in New Zealand. Finally, consistent with recent reports on the politicization of the COVID-19 pandemic, an exploratory question found that participants who rated themselves as more conservative tended to report lower FCV-19S scores. The English version of the COVID-19S is a sound unidimensional scale with robust psychometric properties and can be used with confidence among English-speaking populations.", "doi": "10.1007/s11469-020-00342-9", "pmid": "32837431", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "342"}, {"db": "pmc", "key": "PMC7295324"}], "notes": [], "created": "2020-12-07T10:35:30.325Z", "modified": "2021-02-26T08:45:48.294Z"}, {"entity": "publication", "iuid": "2d6e328ee4c3402cb4cf9ce713a48b68", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d6e328ee4c3402cb4cf9ce713a48b68.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d6e328ee4c3402cb4cf9ce713a48b68"}}, "title": "Analysing the Combined Health, Social and Economic Impacts of the Corovanvirus Pandemic Using Agent-Based Social Simulation.", "authors": [{"family": "Dignum", "given": "Frank", "initials": "F"}, {"family": "Dignum", "given": "Virginia", "initials": "V"}, {"family": "Davidsson", "given": "Paul", "initials": "P"}, {"family": "Ghorbani", "given": "Amineh", "initials": "A"}, {"family": "van der Hurk", "given": "Mijke", "initials": "M"}, {"family": "Jensen", "given": "Maarten", "initials": "M"}, {"family": "Kammler", "given": "Christian", "initials": "C"}, {"family": "Lorig", "given": "Fabian", "initials": "F"}, {"family": "Ludescher", "given": "Luis Gustavo", "initials": "LG"}, {"family": "Melchior", "given": "Alexander", "initials": "A"}, {"family": "Mellema", "given": "Ren\u00e9", "initials": "R"}, {"family": "Pastrav", "given": "Cezara", "initials": "C"}, {"family": "Vanhee", "given": "Lo\u00efs", "initials": "L"}, {"family": "Verhagen", "given": "Harko", "initials": "H"}], "type": "journal article", "published": "2020-06-15", "journal": {"title": "Minds Mach (Dordr)", "issn": "0924-6495", "volume": null, "issue": null, "pages": "1-18", "issn-l": null}, "abstract": "During the COVID-19 crisis there have been many difficult decisions governments and other decision makers had to make. E.g. do we go for a total lock down or keep schools open? How many people and which people should be tested? Although there are many good models from e.g. epidemiologists on the spread of the virus under certain conditions, these models do not directly translate into the interventions that can be taken by government. Neither can these models contribute to understand the economic and/or social consequences of the interventions. However, effective and sustainable solutions need to take into account this combination of factors. In this paper, we propose an agent-based social simulation tool, ASSOCC, that supports decision makers understand possible consequences of policy interventions, but exploring the combined social, health and economic consequences of these interventions.", "doi": "10.1007/s11023-020-09527-6", "pmid": "32836870", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "9527"}, {"db": "pmc", "key": "PMC7294191"}], "notes": [], "created": "2020-12-07T10:38:03.484Z", "modified": "2020-12-07T10:38:12.876Z"}, {"entity": "publication", "iuid": "e97cac63bbe14a28bca026bd3303fab7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e97cac63bbe14a28bca026bd3303fab7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e97cac63bbe14a28bca026bd3303fab7"}}, "title": "Rotational Thromboelastometry predicts care level in COVID-19", "authors": [{"family": "Almskog", "given": "Lou M", "initials": "LM"}, {"family": "Wikman", "given": "Agneta", "initials": "A"}, {"family": "Svensson", "given": "Jonas", "initials": "J"}, {"family": "Wanecek", "given": "Michael", "initials": "M"}, {"family": "Bottai", "given": "Matteo", "initials": "M"}, {"family": "van der Linden", "given": "Jan", "initials": "J"}, {"family": "\u00c5gren", "given": "Anna", "initials": "A"}], "type": "posted-content", "published": "2020-06-12", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.06.11.20128710", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-05-17T19:32:22.986Z", "modified": "2021-05-18T08:00:25.274Z"}, {"entity": "publication", "iuid": "8341c717ee3f4a4a98ccae033bcad53b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8341c717ee3f4a4a98ccae033bcad53b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8341c717ee3f4a4a98ccae033bcad53b"}}, "title": "Has Sweden's controversial covid-19 strategy been successful?", "authors": [{"family": "Habib", "given": "Heba", "initials": "H"}], "type": "journal article", "published": "2020-06-12", "journal": {"title": "BMJ", "issn": "1756-1833", "volume": "369", "issue": null, "pages": "m2376", "issn-l": null}, "abstract": null, "doi": "10.1136/bmj.m2376", "pmid": "32532807", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-09T07:57:08.125Z", "modified": "2020-12-09T07:57:08.135Z"}, {"entity": "publication", "iuid": "0d5ace8c4e674605b00185201e9bfcbd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0d5ace8c4e674605b00185201e9bfcbd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0d5ace8c4e674605b00185201e9bfcbd"}}, "title": "COVID-19 pandemic: Practical considerations on the organization of an allergy clinic - an EAACI/ARIA Position Paper.", "authors": [{"family": "Pfaar", "given": "O", "initials": "O"}, {"family": "Klimek", "given": "L", "initials": "L"}, {"family": "Jutel", "given": "M", "initials": "M"}, {"family": "Akdis", "given": "C A", "initials": "CA"}, {"family": "Bousquet", "given": "J", "initials": "J"}, {"family": "Breiteneder", "given": "H", "initials": "H"}, {"family": "Chinthrajah", "given": "S", "initials": "S"}, {"family": "Diamant", "given": "Z", "initials": "Z"}, {"family": "Eiwegger", "given": "T", "initials": "T"}, {"family": "Fokkens", "given": "W J", "initials": "WJ"}, {"family": "Fritsch", "given": "H W", "initials": "HW"}, {"family": "Nadeau", "given": "K C", "initials": "KC"}, {"family": "O'Hehir", "given": "R E", "initials": "RE"}, {"family": "O'Mahony", "given": "L", "initials": "L"}, {"family": "Rief", "given": "W", "initials": "W"}, {"family": "Sampath", "given": "V", "initials": "V"}, {"family": "Schedlowski", "given": "M", "initials": "M"}, {"family": "Torres", "given": "M", "initials": "M"}, {"family": "Traidl-Hoffmann", "given": "C", "initials": "C"}, {"family": "Wang", "given": "D Y", "initials": "DY"}, {"family": "Zhang", "given": "L", "initials": "L"}, {"family": "Bonini", "given": "M", "initials": "M"}, {"family": "Brehler", "given": "R", "initials": "R"}, {"family": "Brough", "given": "H A", "initials": "HA"}, {"family": "Chivato", "given": "T", "initials": "T"}, {"family": "Del Giacco", "given": "S", "initials": "S"}, {"family": "Dramburg", "given": "S", "initials": "S"}, {"family": "Gawlik", "given": "R", "initials": "R"}, {"family": "Gelincik", "given": "A", "initials": "A"}, {"family": "Hoffmann-Sommergruber", "given": "K", "initials": "K"}, {"family": "Hox", "given": "V", "initials": "V"}, {"family": "Knol", "given": "E", "initials": "E"}, {"family": "Lauerma", "given": "A", "initials": "A"}, {"family": "Matricardi", "given": "P M", "initials": "PM"}, {"family": "Mortz", "given": "C G", "initials": "CG"}, {"family": "Ollert", "given": "M", "initials": "M"}, {"family": "Palomares", "given": "O", "initials": "O"}, {"family": "Riggioni", "given": "C", "initials": "C"}, {"family": "Schwarze", "given": "J", "initials": "J"}, {"family": "Skypala", "given": "I", "initials": "I"}, {"family": "Untersmayr", "given": "S", "initials": "S"}, {"family": "Walusiak-Skorupa", "given": "J", "initials": "J"}, {"family": "Ansotegui", "given": "I", "initials": "I"}, {"family": "Bachert", "given": "C", "initials": "C"}, {"family": "Bedbrook", "given": "A", "initials": "A"}, {"family": "Bosnic-Anticevich", "given": "S", "initials": "S"}, {"family": "Brussino", "given": "L", "initials": "L"}, {"family": "Canonica", "given": "G W", "initials": "GW"}, {"family": "Cardona", "given": "V", "initials": "V"}, {"family": "Carreiro-Martins", "given": "P", "initials": "P"}, {"family": "Cruz", "given": "A A", "initials": "AA"}, {"family": "Czarlewski", "given": "W", "initials": "W"}, {"family": "Fonseca", "given": "J A", "initials": "JA"}, {"family": "Gotua", "given": "M", "initials": "M"}, {"family": "Haatela", "given": "T", "initials": "T"}, {"family": "Ivancevich", "given": "J C", "initials": "JC"}, {"family": "Kuna", "given": "P", "initials": "P"}, {"family": "Kvedariene", "given": "V", "initials": "V"}, {"family": "Larenas-Linnemann", "given": "D", "initials": "D"}, {"family": "Latiff", "given": "A", "initials": "A"}, {"family": "Morais-Almeida", "given": "M", "initials": "M"}, {"family": "Mullol", "given": "J", "initials": "J"}, {"family": "Naclerio", "given": "R", "initials": "R"}, {"family": "Ohta", "given": "K", "initials": "K"}, {"family": "Okamoto", "given": "Y", "initials": "Y"}, {"family": "Onorato", "given": "G L", "initials": "GL"}, {"family": "Papadopoulos", "given": "N G", "initials": "NG"}, {"family": "Patella", "given": "V", "initials": "V"}, {"family": "Regateiro", "given": "F S", "initials": "FS"}, {"family": "Samolinski", "given": "B", "initials": "B"}, {"family": "Suppli Ulrik", "given": "C", "initials": "C"}, {"family": "Toppila-Salmi", "given": "S", "initials": "S"}, {"family": "Valiulis", "given": "A", "initials": "A"}, {"family": "Ventura", "given": "M T", "initials": "MT"}, {"family": "Yorgancioglu", "given": "A", "initials": "A"}, {"family": "Zuberbier", "given": "T", "initials": "T"}, {"family": "Agache", "given": "I", "initials": "I"}], "type": "journal article", "published": "2020-06-12", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": "76", "issue": "3", "pages": "648-676", "issn-l": "0105-4538"}, "abstract": "The Coronavirus disease 2019 (COVID-19) has evolved as a pandemic infectious disease transmitted by the severe acute respiratory syndrome coronavirus (SARS-CoV-)2. Allergists and other health care providers (HCPs) in the field of allergies and associated airway diseases are in the front line, taking care of patients potentially infected with SARS-CoV-2. Hence, strategies and practices to minimize risks of infection for both HCPs and treated patients have to be developed and followed by allergy clinics.\n\nThe scientific information on COVID-19 was analyzed by a literature search in Medline, Pubmed, national and international guidelines from the European Academy of Allergy and Clinical Immunology (EAACI), the Cochrane Library and the Internet.\n\nBased on diagnostic and treatment standards developed by EAACI, on international information regarding COVID-19, on guidelines of the World Health Organization (WHO) and other international organizations as well as on previous experience, a panel of experts including clinicians, psychologists, IT experts and basic scientists along with EAACI and the \"Allergic Rhinitis and its Impact on Asthma (ARIA)\" inititiative have developed recommendations for the optimal management of allergy clinics during the current COVID-19 pandemic. These recommendations are grouped into nine sections on different relevant aspects for the care of patients with allergies.\n\nThis international Position Paper provides recommendations on operational plans and procedures to maintain high standards in the daily clinical care of allergic patients whilst ensuring necessary safety in the current COVID-19 pandemic.", "doi": "10.1111/all.14453", "pmid": "32531110", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7323448"}], "notes": [], "created": "2020-11-25T09:59:36.828Z", "modified": "2021-04-23T16:11:47.867Z"}, {"entity": "publication", "iuid": "162889acebf541c4aa975e0920e09255", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/162889acebf541c4aa975e0920e09255.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/162889acebf541c4aa975e0920e09255"}}, "title": "Proteomic Profiling in Biracial Cohorts Implicates DC-SIGN as a Mediator of Genetic Risk in COVID-19", "authors": [{"family": "Katz", "given": "Daniel H", "initials": "DH", "orcid": "0000-0001-7237-8502", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b20cc0e5af5a45afbd1437ae5f67e1f9.json"}}, {"family": "Tahir", "given": "Usman A", "initials": "UA"}, {"family": "Ngo", "given": "Debby", "initials": "D"}, {"family": "Benson", "given": "Mark", "initials": "M"}, {"family": "Bick", "given": "Alexander G", "initials": "AG"}, {"family": "Pampana", "given": "Akhil", "initials": "A"}, {"family": "Gao", "given": "Yan", "initials": "Y"}, {"family": "Keyes", "given": "Michelle J", "initials": "MJ"}, {"family": "Correa", "given": "Adolfo", "initials": "A"}, {"family": "Sinha", "given": "Sumita", "initials": "S"}, {"family": "Shen", "given": "Dongxiao", "initials": "D"}, {"family": "Yang", "given": "Qiong", "initials": "Q"}, {"family": "Robbins", "given": "Jeremy M", "initials": "JM"}, {"family": "Chen", "given": "Zsu Zsu", "initials": "ZZ"}, {"family": "Cruz", "given": "Daniel E", "initials": "DE"}, {"family": "Peterson", "given": "Bennet", "initials": "B"}, {"family": "Natarajan", "given": "Pradeep", "initials": "P"}, {"family": "Vasan", "given": "Ramachandran S", "initials": "RS"}, {"family": "Smith", "given": "J Gustav", "initials": "JG"}, {"family": "Wang", "given": "Thomas J", "initials": "TJ"}, {"family": "Wilson", "given": "James G", "initials": "JG"}, {"family": "Gerszten", "given": "Robert E", "initials": "RE"}], "type": "posted-content", "published": "2020-06-11", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.06.09.20125690", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Health": null, "Category: Genomics & transcriptomics": null}, "xrefs": [], "notes": [], "created": "2021-06-17T07:59:56.735Z", "modified": "2021-06-17T08:00:14.173Z"}, {"entity": "publication", "iuid": "a11cb5cd27c844e589b01a7d4df0c679", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a11cb5cd27c844e589b01a7d4df0c679.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a11cb5cd27c844e589b01a7d4df0c679"}}, "title": "Associations Between Fear of COVID-19, Mental Health, and Preventive Behaviours Across Pregnant Women and Husbands: An Actor-Partner Interdependence Modelling.", "authors": [{"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Imani", "given": "Vida", "initials": "V"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Timpka", "given": "Toomas", "initials": "T"}, {"family": "Brostr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Updegraff", "given": "John A", "initials": "JA"}, {"family": "\u00c5restedt", "given": "Kristofer", "initials": "K"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "journal article", "published": "2020-06-11", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "issn-l": null, "volume": null, "issue": null, "pages": "1-15"}, "abstract": "The present cross-sectional study examined the actor-partner interdependence effect of fear of COVID-19 among Iranian pregnant women and their husbands and its association with their mental health and preventive behaviours during the first wave of the COVID-19 pandemic in 2020. A total of 290 pregnant women and their husbands ( N = 580) were randomly selected from a list of pregnant women in the Iranian Integrated Health System and were invited to respond to psychometric scales assessing fear of COVID-19, depression, anxiety, suicidal intention, mental quality of life, and COVID-19 preventive behaviours. The findings demonstrated significant dyadic relationships between husbands and their pregnant wives' fear of COVID-19, mental health, and preventive behaviours. Pregnant wives' actor effect of fear of COVID-19 was significantly associated with depression, suicidal intention, mental quality of life, and COVID-19 preventive behaviours but not anxiety. Moreover, a husband actor effect of fear of COVID-19 was significantly associated with depression, anxiety, suicidal intention, mental quality of life, and COVID-19 preventive behaviours. Additionally, there were significant partner effects observed for both the pregnant wives and their husbands concerning all outcomes. The present study used a cross-sectional design and so is unable to determine the mechanism or causal ordering of the effects. Also, the data are mainly based on self-reported measures which have some limitations due to its potential for social desirability and recall biases. Based on the findings, couples may benefit from psychoeducation that focuses on the effect of mental health problems on pregnant women and the foetus.", "doi": "10.1007/s11469-020-00340-x", "pmid": "32837427", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "340"}, {"db": "pmc", "key": "PMC7289236"}], "notes": [], "created": "2020-12-07T10:36:04.681Z", "modified": "2021-02-26T08:47:00.131Z"}, {"entity": "publication", "iuid": "80ba3c6566dd4245b48fae35ee04d17a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/80ba3c6566dd4245b48fae35ee04d17a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/80ba3c6566dd4245b48fae35ee04d17a"}}, "title": "Two complementary model-based methods for calculating the risk of international spreading of a novel virus from the outbreak epicentre. The case of COVID-19.", "authors": [{"family": "Massad", "given": "Eduardo", "initials": "E"}, {"family": "Amaku", "given": "Marcos", "initials": "M"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Costa Dos Santos", "given": "Paulo Cesar", "initials": "PC"}, {"family": "Struchiner", "given": "Claudio Jose", "initials": "CJ"}, {"family": "Coutinho", "given": "Francisco Antonio Bezerra", "initials": "FAB"}], "type": "journal article", "published": "2020-06-09", "journal": {"title": "Epidemiol Infect", "issn": "1469-4409", "volume": "148", "issue": null, "pages": "e109", "issn-l": null}, "abstract": "We present two complementary model-based methods for calculating the risk of international spread of the novel coronavirus SARS-CoV-2 from the outbreak epicentre. One model aims to calculate the number of cases that would be exported from an endemic country to disease-free regions by travellers. The second model calculates the probability that an infected traveller will generate at least one secondary autochthonous case in the visited country. Although this paper focuses on the data from China, our methods can be adapted to calculate the risk of importation and subsequent outbreaks. We found an average R0 = 5.31 (ranging from 4.08 to 7.91) and a risk of spreading of 0.75 latent individuals per 1000 travellers. In addition, one infective traveller would be able to generate at least one secondary autochthonous case in the visited country with a probability of 23%.", "doi": "10.1017/S0950268820001223", "pmid": "32513345", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "S0950268820001223"}, {"db": "pmc", "key": "PMC7298081"}], "notes": [], "created": "2020-12-09T10:32:44.837Z", "modified": "2021-02-26T08:46:13.339Z"}, {"entity": "publication", "iuid": "bea00c18be9a4b858823b661f7fd1093", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bea00c18be9a4b858823b661f7fd1093.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bea00c18be9a4b858823b661f7fd1093"}}, "title": "Sampling bias and incorrect rooting make phylogenetic network tracing of SARS-COV-2 infections unreliable.", "authors": [{"family": "Mavian", "given": "Carla", "initials": "C", "orcid": "0000-0003-3819-5520", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1480d0856ce148d49095321cc9c69977.json"}}, {"family": "Pond", "given": "Sergei Kosakovsky", "initials": "SK"}, {"family": "Marini", "given": "Simone", "initials": "S"}, {"family": "Magalis", "given": "Brittany Rife", "initials": "BR", "orcid": "0000-0001-6088-4651", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/13ad1ff37ac54221bf1b1bbd68e37448.json"}}, {"family": "Vandamme", "given": "Anne-Mieke", "initials": "AM"}, {"family": "Dellicour", "given": "Simon", "initials": "S"}, {"family": "Scarpino", "given": "Samuel V", "initials": "SV", "orcid": "0000-0001-5716-2770", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/90b3b5f60b4745bda076bfa5c36e2201.json"}}, {"family": "Houldcroft", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1833-5285", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1058544bcab84e37b4e9442b80fbd398.json"}}, {"family": "Villabona-Arenas", "given": "Julian", "initials": "J"}, {"family": "Paisie", "given": "Taylor K", "initials": "TK", "orcid": "0000-0002-6024-2744", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/cf0ca78109e2489eb19d25f2bb9d69c2.json"}}, {"family": "Trov\u00e3o", "given": "N\u00eddia S", "initials": "NS", "orcid": "0000-0002-2106-1166", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b13a1d1532074e8c812b4ad41600e17d.json"}}, {"family": "Boucher", "given": "Christina", "initials": "C"}, {"family": "Zhang", "given": "Yun", "initials": "Y"}, {"family": "Scheuermann", "given": "Richard H", "initials": "RH"}, {"family": "Gascuel", "given": "Olivier", "initials": "O"}, {"family": "Lam", "given": "Tommy Tsan-Yuk", "initials": "TT"}, {"family": "Suchard", "given": "Marc A", "initials": "MA"}, {"family": "Abecasis", "given": "Ana", "initials": "A"}, {"family": "Wilkinson", "given": "Eduan", "initials": "E"}, {"family": "de Oliveira", "given": "Tulio", "initials": "T"}, {"family": "Bento", "given": "Ana I", "initials": "AI", "orcid": "0000-0001-7728-007X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4cc7effceac545aeb92eaa1dd0d8eea3.json"}}, {"family": "Schmidt", "given": "Heiko A", "initials": "HA", "orcid": "0000-0002-2311-8592", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e11b64fb6ed74b50ad88b6d6725c212b.json"}}, {"family": "Martin", "given": "Darren", "initials": "D"}, {"family": "Hadfield", "given": "James", "initials": "J"}, {"family": "Faria", "given": "Nuno", "initials": "N"}, {"family": "Grubaugh", "given": "Nathan D", "initials": "ND"}, {"family": "Neher", "given": "Richard A", "initials": "RA"}, {"family": "Baele", "given": "Guy", "initials": "G", "orcid": "0000-0002-1915-7732", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4ed706bd4a744d8da6a2561880e98eba.json"}}, {"family": "Lemey", "given": "Philippe", "initials": "P"}, {"family": "Stadler", "given": "Tanja", "initials": "T"}, {"family": "Albert", "given": "Jan", "initials": "J"}, {"family": "Crandall", "given": "Keith A", "initials": "KA", "orcid": "0000-0002-0836-3389", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fc79bb378b6b473abaa11659ec9620b9.json"}}, {"family": "Leitner", "given": "Thomas", "initials": "T", "orcid": "0000-0001-8160-2588", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c26a4f8a2e204bc5930718c55a6d4a25.json"}}, {"family": "Stamatakis", "given": "Alexandros", "initials": "A"}, {"family": "Prosperi", "given": "Mattia", "initials": "M", "orcid": "0000-0002-9021-5595", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/73d6b84d966e4738a7ab4556013b3a63.json"}}, {"family": "Salemi", "given": "Marco", "initials": "M"}], "type": "letter", "published": "2020-06-09", "journal": {"title": "Proc Natl Acad Sci U S A", "issn": "1091-6490", "volume": "117", "issue": "23", "pages": "12522-12523", "issn-l": "0027-8424"}, "abstract": "Comment", "doi": "10.1073/pnas.2007295117", "pmid": "32381734", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7293693"}, {"db": "pii", "key": "2007295117"}], "notes": [], "created": "2020-11-25T07:31:25.225Z", "modified": "2023-06-19T15:37:57.813Z"}, {"entity": "publication", "iuid": "ae0bfe026d6d4e9c8821e05c1b33e008", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ae0bfe026d6d4e9c8821e05c1b33e008.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ae0bfe026d6d4e9c8821e05c1b33e008"}}, "title": "Clinical Characteristics of COVID-19 Patients With Gastrointestinal Symptoms: An Analysis of Seven Patients in China.", "authors": [{"family": "Ai", "given": "Jin-Wei", "initials": "JW"}, {"family": "Zi", "given": "Hao", "initials": "H"}, {"family": "Wang", "given": "Yong", "initials": "Y"}, {"family": "Huang", "given": "Qiao", "initials": "Q"}, {"family": "Wang", "given": "Na", "initials": "N"}, {"family": "Li", "given": "Lu-Yao", "initials": "LY"}, {"family": "Pei", "given": "Bin", "initials": "B"}, {"family": "Ji", "given": "Jianguang", "initials": "J"}, {"family": "Zeng", "given": "Xian-Tao", "initials": "XT"}], "type": "journal article", "published": "2020-06-09", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "7", "issue": null, "pages": "308", "issn-l": null}, "abstract": "Objectives: Patients with novel coronavirus disease 2019 (COVID-19) can present with gastrointestinal symptoms as their initial symptoms or as the main manifestations during disease progression, but the clinical characteristics of these patients are still unknown. Methods: We identified COVID-19 patients who admitted to Xiangyang No. 1 People's Hospital and presented with gastrointestinal symptoms as their initial or main symptoms. Their medical records were reviewed by two independent clinical scientists. The epidemiological and clinical characteristics as well as the clinical outcomes were analyzed. Results: Among 142 confirmed COVID-19 cases, 7 (4.9%) of them presented with gastrointestinal symptoms. Three patients had gastrointestinal symptoms as the initial symptoms and chief complaints, and 4 patients as the main symptoms during disease progression. Six patients had symptoms of diarrhea (3-16 days), 7 with anorexia (7-22 days), 6 with upper abdominal discomfort (1-7 days), and 4 with nausea (1-7 days), 1 with heartburn lasting 2 days, and 2 with vomiting symptoms (1 day). The chest CT scan showed typical COVID-19 imaging features, and associated with the progression of the disease. During treatment, 2 patients died due to organ failure. Discussion: COVID-19 patients with gastrointestinal symptoms are relatively rare and might be misdiagnosed. The clinical features include watery stools, anorexia, and upper abdominal discomfort. These patients may have severe disease and be associated with a poor prognosis. The underlying mechanisms of SARS-CoV-2 related gastrointestinal symptoms need to clarify in future studies.", "doi": "10.3389/fmed.2020.00308", "pmid": "32656221", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7325892"}], "notes": [], "created": "2020-12-08T14:15:30.089Z", "modified": "2021-02-26T08:45:48.571Z"}, {"entity": "publication", "iuid": "39cbb22196de4f19883ea00af5966044", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/39cbb22196de4f19883ea00af5966044.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/39cbb22196de4f19883ea00af5966044"}}, "title": "Correction: The challenge of COVID-19 and hematopoietic cell transplantation: EBMT recommendations for management of hematopoietic cell transplant recipients, their donors, and patients undergoing CAR T-cell therapy.", "authors": [{"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Mikulska", "given": "Malgorzata", "initials": "M"}, {"family": "de la Camara", "given": "Rafael", "initials": "R"}, {"family": "Basak", "given": "Grzegorz W", "initials": "GW"}, {"family": "Chabannon", "given": "Christian", "initials": "C"}, {"family": "Corbacioglu", "given": "Selim", "initials": "S"}, {"family": "Duarte", "given": "Rafael", "initials": "R"}, {"family": "Dolstra", "given": "Harry", "initials": "H"}, {"family": "Lankester", "given": "Arjan C", "initials": "AC"}, {"family": "Mohty", "given": "Mohamad", "initials": "M"}, {"family": "Montoto", "given": "Silvia", "initials": "S"}, {"family": "Murray", "given": "John", "initials": "J"}, {"family": "de Latour", "given": "R\u00e9gis Peffault", "initials": "RP"}, {"family": "Snowden", "given": "John A", "initials": "JA"}, {"family": "Yakoub-Agha", "given": "Ibrahim", "initials": "I"}, {"family": "Verhoeven", "given": "Bregje", "initials": "B"}, {"family": "Kr\u00f6ger", "given": "Nicolaus", "initials": "N"}, {"family": "Styczynski", "given": "Jan", "initials": "J"}, {"family": "European Society for Blood and Marrow Transplantation", "given": "", "initials": ""}], "type": "published erratum", "published": "2020-06-08", "journal": {"title": "Bone Marrow Transplant", "issn": "1476-5365", "volume": null, "issue": null, "issn-l": "0268-3369"}, "abstract": "An amendment to this paper has been published and can be accessed via a link at the top of the paper.", "doi": "10.1038/s41409-020-0965-7", "pmid": "32514158", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41409-020-0965-7"}, {"db": "pmc", "key": "PMC7278762"}], "notes": [], "created": "2020-11-25T09:56:54.993Z", "modified": "2020-12-09T10:32:02.389Z"}, {"entity": "publication", "iuid": "112efbced8284cb695c6852237f4b604", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/112efbced8284cb695c6852237f4b604.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/112efbced8284cb695c6852237f4b604"}}, "title": "The influence of the SARS-CoV-2 pandemic on esophagogastric cancer services: an international survey of esophagogastric surgeons.", "authors": [{"family": "Kamarajah", "given": "Sivesh K", "initials": "SK"}, {"family": "Markar", "given": "Sheraz R", "initials": "SR"}, {"family": "Singh", "given": "Pritam", "initials": "P"}, {"family": "Griffiths", "given": "Ewen A", "initials": "EA"}, {"family": "Oesophagogastric Anastomosis Audit Group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-06-05", "journal": {"title": "Dis Esophagus", "issn": "1442-2050", "issn-l": "1120-8694", "volume": null, "issue": null, "pages": null}, "abstract": "Several guidelines to guide clinical practice among esophagogastric surgeons during the COVID-19 pandemic were produced. However, none provide reflection of current service provision. This international survey aimed to clarify the changes observed in esophageal and gastric cancer management and surgery during the COVID-19 pandemic.\r\n\r\nAn online survey covering key areas for esophagogastric cancer services, including staging investigations and oncological and surgical therapy before and during (at two separate time-points-24th March 2020 and 18th April 2020) the COVID-19 pandemic were developed.\r\n\r\nA total of 234 respondents from 225 centers and 49 countries spanning six continents completed the first round of the online survey, of which 79% (n = 184) completed round 2. There was variation in the availability of staging investigations ranging from 26.5% for endoscopic ultrasound to 62.8% for spiral computed tomography scan. Definitive chemoradiotherapy was offered in 14.8% (adenocarcinoma) and 47.0% (squamous cell carcinoma) of respondents and significantly increased by almost three-fold and two-fold, respectively, in both round 1 and 2. There were uncertainty and heterogeneity surrounding prioritization of patients undergoing cancer resections. Of the surgeons symptomatic with COVID-19, only 40.2% (33/82) had routine access to COVID-19 polymerase chain reaction testing for staff. Of those who had testing available (n = 33), only 12.1% (4/33) had tested positive.\r\n\r\nThese data highlight management challenges and several practice variations in caring for patients with esophagogastric cancers. Therefore, there is a need for clear consistent guidelines to be in place in the event of a further pandemic to ensure a standardized level of oncological care for patients with esophagogastric cancers.", "doi": "10.1093/dote/doaa054", "pmid": "32500134", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "5851505"}, {"db": "pmc", "key": "PMC7314222"}], "notes": [], "created": "2020-11-25T09:44:08.645Z", "modified": "2022-11-10T07:53:55.709Z"}, {"entity": "publication", "iuid": "f8d08d0b526240e2b6ab9f13216bea3e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f8d08d0b526240e2b6ab9f13216bea3e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f8d08d0b526240e2b6ab9f13216bea3e"}}, "title": "Severe inflammation in children - cause for awareness during the current pandemic", "authors": [{"family": "Horne", "given": "AnnaCarin", "initials": "A"}, {"family": "Nordenh\u00e4ll", "given": "Lotta", "initials": "L"}], "type": "journal article", "published": "2020-06-05", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": "Clinical manifestations of COVID-19 in children are generally mild and many are asymptomatic. However, recent international reports have described clusters of children presenting with an unusual syndrome of high, persistent fever, severe inflammation and single- or multiorgan dysfunction, with a suspected association to COVID-19 pandemic. It is recommended that clinicians are aware of this rare syndrome and that suspected cases are treated in a multidisciplinary setting.", "doi": null, "pmid": "32542615", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "20094"}], "notes": [], "created": "2020-11-25T10:07:27.646Z", "modified": "2020-12-08T07:19:25.327Z"}, {"entity": "publication", "iuid": "5a3f35577cf0436ea0a28d8f046de55f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5a3f35577cf0436ea0a28d8f046de55f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5a3f35577cf0436ea0a28d8f046de55f"}}, "title": "Changes in Gambling Behavior during the COVID-19 Pandemic-A Web Survey Study in Sweden.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-06-05", "journal": {"title": "Int J Environ Res Public Health", "issn": "1660-4601", "issn-l": null, "volume": "17", "issue": "11", "pages": null}, "abstract": "The COVID-19 pandemic has dramatically changed everyday life, and policy makers have raised concerns about possible changes in gambling patterns during the pandemic. This study aimed to examine whether self-reported gambling has increased during the pandemic, and to examine potential correlates of such a change. This general population survey study in Sweden collected self-report data from 2016 web survey members (51 percent men, nine percent moderate-risk/problem gamblers). Correlates of increased gambling and increased gambling specifically due to COVID-19-related cancellation of sports were calculated. Four percent reported an overall gambling increase during the pandemic. The proportion of individuals reporting an increase, compared to individuals reporting a decrease, was markedly higher for online casinos (0.62), online horse betting (0.76) and online lotteries (0.73), and lower for sports betting (0.11). Overall, gambling increases were independently associated with gambling problems and increased alcohol consumption. In the sub-group, where there was an increase in specific gambling types in response to cancelled sports betting events, rates of gambling problems were high. In conclusion, only a minority report increased gambling in response to the pandemic, but this group has markedly higher gambling problems and changes in alcohol consumption, and may represent a sub-group with a particularly high vulnerability. This calls for preventive action in people with higher gambling risks in response to the pandemic.", "doi": "10.3390/ijerph17114013", "pmid": "32516880", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "ijerph17114013"}, {"db": "pmc", "key": "PMC7312016"}], "notes": [], "created": "2020-12-09T10:30:11.240Z", "modified": "2022-11-10T07:54:17.524Z"}, {"entity": "publication", "iuid": "0be77bad07c449b1adfe016d20bbdcd6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0be77bad07c449b1adfe016d20bbdcd6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0be77bad07c449b1adfe016d20bbdcd6"}}, "title": "Detection of asymptomatic SARS-CoV-2 exposed individuals by a sensitive S-based ELISA", "authors": [{"family": "Rosendal", "given": "Ebba", "initials": "E"}, {"family": "Bystr\u00f6m", "given": "Julia Wigren", "initials": "JW"}, {"family": "Gr\u00f6ning", "given": "Remigius", "initials": "R"}, {"family": "Gwon", "given": "Yong Dae", "initials": "YD"}, {"family": "Nilsson", "given": "Emma", "initials": "E"}, {"family": "Sharma", "given": "Atin", "initials": "A"}, {"family": "Espaillat", "given": "Akbar", "initials": "A"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Thunberg", "given": "Therese", "initials": "T"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "Puhar", "given": "Andrea", "initials": "A"}, {"family": "Cava", "given": "Felipe", "initials": "F"}, {"family": "Hedestam", "given": "Gunilla B Karlsson", "initials": "GBK"}, {"family": "Monsen", "given": "Tor", "initials": "T"}, {"family": "Elgh", "given": "Fredrik", "initials": "F"}, {"family": "Blomkvist", "given": "Bert", "initials": "B"}, {"family": "Marklund", "given": "Ingrid", "initials": "I"}, {"family": "Ahlm", "given": "Clas", "initials": "C"}, {"family": "Evander", "given": "Magnus", "initials": "M"}, {"family": "Normark", "given": "Johan", "initials": "J"}, {"family": "Johansson", "given": "Anders", "initials": "A"}, {"family": "\u00d6verby", "given": "Anna K", "initials": "AK"}, {"family": "Forsell", "given": "Mattias NE", "initials": "MN", "orcid": "0000-0001-6904-742X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e41c0e1c9c7b499fb3d844d4c572e7bb.json"}}], "type": "posted-content", "published": "2020-06-04", "journal": {"title": "medRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": "To assess the current coronavirus pandemic, there is a pressing need to determine the exposure and seroconversion to SARS-CoV-2 on a local and global level. Here, we demonstrate a sensitive and specific S-protein based assay that is well suited for detection of weak SARS- CoV-2-directed IgG responses, and that could identify exposed individuals with asymptomatic infection without the requirement of PCR diagnostics. Our results raise the possibility that on- going population-based studies using less sensitive state-of-the-art serological assays may significantly underestimate the frequency of exposure and seroconversion to SARS-CoV-2.", "doi": "10.1101/2020.06.02.20120477", "pmid": "32577692", "labels": {"Funder: KAW/SciLifeLab": null, "Funder: Vinnova": null, "Type: Preprint": null, "Funder: VR": null, "Research Area: Biobanks for COVID-19 research": null, "Research Area: Host cell systems biology and targets": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-11-04T15:53:34.262Z", "modified": "2021-12-22T13:24:39.638Z"}, {"entity": "publication", "iuid": "4a19975d90fc4ffc8b4111c6836782d2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4a19975d90fc4ffc8b4111c6836782d2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4a19975d90fc4ffc8b4111c6836782d2"}}, "title": "The term \"physical distancing\" is recommended rather than \"social distancing\" during the COVID-19 pandemic for reducing feelings of rejection among people with mental health problems.", "authors": [{"family": "Wasserman", "given": "Danuta", "initials": "D"}, {"family": "van der Gaag", "given": "Rutger", "initials": "R"}, {"family": "Wise", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2020-06-01", "journal": {"title": "Eur Psychiatry", "issn": "1778-3585", "issn-l": "0924-9338", "volume": "63", "issue": "1", "pages": "e52"}, "abstract": "As COVID-19 has plagued our world, the term \"social distancing\" has been widely used with the aim to encourage the general population to physically distance themselves from others in order to reduce the spread of the virus. However, this term can have unintended but detrimental effects, as it evokes negative feelings of being ignored, unwelcome, left alone with one's own fears, and even excluded from society. These feelings may be stronger in people with mental illnesses and in socio-economically disadvantaged groups, such as stigmatized minorities, migrants, and homeless persons [1], many of them also having high risk for suicidal behaviors [2]. Mental health disorders are pervasive worldwide; the global burden accounting for approximately 21.2-32.4% of years lived with disability-more than any other group of illnesses [3]. So, the vulnerable group of people with mental health disorders represents a considerable share of the total global population.", "doi": "10.1192/j.eurpsy.2020.60", "pmid": "32475365", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "S0924933820000607"}, {"db": "pmc", "key": "PMC7287304"}], "notes": [], "created": "2020-11-25T09:29:57.335Z", "modified": "2022-11-10T07:54:44.175Z"}, {"entity": "publication", "iuid": "c1e74612a5d64ee89229777ca2d62d81", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1e74612a5d64ee89229777ca2d62d81.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1e74612a5d64ee89229777ca2d62d81"}}, "title": "Recommendations for the management of patients with immune-mediated kidney disease during the severe acute respiratory syndrome coronavirus 2 pandemic.", "authors": [{"family": "Anders", "given": "Hans-Joachim", "initials": "HJ"}, {"family": "Bruchfeld", "given": "Annette", "initials": "A"}, {"family": "Fernandez Juarez", "given": "Gema Maria", "initials": "GM"}, {"family": "Floege", "given": "J\u00fcrgen", "initials": "J"}, {"family": "Goumenos", "given": "Dimitrios", "initials": "D"}, {"family": "Turkmen", "given": "Kultigin", "initials": "K"}, {"family": "van Kooten", "given": "Cees", "initials": "C"}, {"family": "Tesar", "given": "Vladimir", "initials": "V"}, {"family": "Segelmark", "given": "M\u00e5rten", "initials": "M"}], "type": "journal article", "published": "2020-06-01", "journal": {"title": "Nephrol Dial Transplant", "issn": "1460-2385", "volume": "35", "issue": "6", "pages": "920-925", "issn-l": "0931-0509"}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has created major challenges for all countries around the globe. Retrospective studies have identified hypertension, cardiovascular disease, diabetes and older age as risk factors for high morbidity and mortality from COVID-19. There is a general concern that patients with immune-mediated kidney diseases, namely those on immunosuppressive therapies and/or those with more advanced kidney failure, could particularly be at risk for adverse outcomes due to a compromised antiviral immunity. Uncertainties exist on how management routines should be reorganized to minimize the risk of severe acute respiratory syndrome coronavirus 2 infection and what measures are necessary for infected patients. The aim of the present review of the Immunonephrology Working Group of the European Renal Association-European Dialysis and Transplant Association is to provide recommendations for the management of patients with immune-mediated kidney diseases based on the available evidence, similar circumstances with other infectious organisms and expert opinions from across Europe. Such recommendations may help to minimize the risk of encountering COVID-19 or developing complications during COVID-19 in patients with immune-mediated kidney disease.", "doi": "10.1093/ndt/gfaa112", "pmid": "32445573", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "5843427"}, {"db": "pmc", "key": "PMC7313759"}], "notes": [], "created": "2020-11-25T09:12:56.146Z", "modified": "2020-11-30T09:03:28.660Z"}, {"entity": "publication", "iuid": "d056cbfa81d345eb837ec8f343f8a79e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d056cbfa81d345eb837ec8f343f8a79e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d056cbfa81d345eb837ec8f343f8a79e"}}, "title": "Measurement of hydroxychloroquine in blood from SLE patients using LC-HRMS-evaluation of whole blood, plasma, and serum as sample matrices.", "authors": [{"family": "Carlsson", "given": "Henrik", "initials": "H"}, {"family": "Hjorton", "given": "Karin", "initials": "K"}, {"family": "Abujrais", "given": "Sandy", "initials": "S"}, {"family": "R\u00f6nnblom", "given": "Lars", "initials": "L"}, {"family": "\u00c5kerfeldt", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Kultima", "given": "Kim", "initials": "K"}], "type": "journal article", "published": "2020-06-01", "journal": {"title": "Arthritis Res Ther", "issn": "1478-6362", "volume": "22", "issue": "1", "pages": "125", "issn-l": "1478-6354"}, "abstract": "Hydroxychloroquine (HCQ) is the standard of care in the treatment of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and other inflammatory rheumatic diseases and potentially for the treatment in COVID-19 patients. Determination of HCQ for therapeutic drug monitoring (TDM) can be performed in whole blood (WB), serum, and plasma. Direct comparisons of WB, serum, and plasma levels of HCQ in patients with SLE have not previously been reported. We describe a method for the determination of HCQ in human blood using liquid chromatography-high-resolution mass spectrometry (LC-HRMS) and compare the suitability of the three sample matrices.\r\n\r\nA method for the determination of HCQ in human blood using LC-HRMS was developed, validated, and applied for the determination of HCQ levels in WB, serum, and plasma from 26 SLE patients. The reproducibility of the method, in the three matrices, was evaluated using quality control samples and repeated preparations and measurements of patient samples. The performance of the developed method for HCQ measurement in serum was further evaluated by comparison with two previously reported extraction methods.\r\n\r\nThe performance of the presented method demonstrated high accuracy and precision. A large range of HCQ concentrations was observed for the SLE patients in all three matrices (WB, serum, and plasma). The mean levels in WB were approximately two-fold the levels in serum and plasma (813 ng/mL compared to 436 ng/mL and 362 ng/mL, respectively). Spiked quality controls showed high reproducibility for all matrices (coefficient of variation, CV, approx. 5%), whereas in patient samples, equally high-precision was only found using WB as the matrix (CV 3%). The CV for serum and plasma was 14% and 39%, respectively. Two alternative methods applied to serum samples did not demonstrate improved precision.\r\n\r\nA LC-HRMS method for the measurement of HCQ in human blood was developed and validated. Whole blood was found to be the superior sample matrix in terms of sample reproducibility. Thus, whole blood samples should be used for HCQ analysis when patients are monitored for HCQ treatment effects. The assay is in clinical use to monitor levels of HCQ in patients.", "doi": "10.1186/s13075-020-02211-1", "pmid": "32475347", "labels": {"Type: Journal article": null, "Category: Health": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13075-020-02211-1"}, {"db": "pmc", "key": "PMC7261520"}], "notes": [], "created": "2020-11-19T14:50:28.058Z", "modified": "2021-02-26T08:46:13.524Z"}, {"entity": "publication", "iuid": "9847a5d1a5084ca1b4ae55e88af59985", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9847a5d1a5084ca1b4ae55e88af59985.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9847a5d1a5084ca1b4ae55e88af59985"}}, "title": "Covid-19 - radiologic and histologic features", "authors": [{"family": "Mari Svensson", "given": "Ann", "initials": "A"}, {"family": "Hansen", "given": "Tomas", "initials": "T"}, {"family": "Nyren", "given": "Sven", "initials": "S"}, {"family": "Csatl\u00f3s", "given": "Martin", "initials": "M"}, {"family": "Brunnstr\u00f6m", "given": "Hans", "initials": "H"}], "type": "journal article", "published": "2020-06-01", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": "We here describe the current knowledge about the radiologic and histologic pulmonary features of covid-19, caused by SARS-CoV-2, and present lung histology from a case with fatal disease. Initial findings on computed tomography (CT) typically include peripheral multifocal bilateral ground-glass opacities, and correspondingly microscopic alveolar edema. This is followed by peripheral consolidations with air bronchogram and perilobular pattern on CT, signs of organizing pneumonia, corresponding to loose (potentially reversible) fibrosis. The posterior parts of the lungs and the lower lobes are typically more markedly affected. In severe disease with acute respiratory distress syndrome, thickened interlobular septa and crazy paving pattern appear on CT, which corresponds to histologic diffuse alveolar damage with, depending on the stage of the disease, features such as edema, hyaline membranes, reactive epithelium, inflammation, and fibrosis.", "doi": null, "pmid": "32484232", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "20086"}], "notes": [], "created": "2020-11-22T08:44:16.883Z", "modified": "2021-02-26T08:45:48.489Z"}, {"entity": "publication", "iuid": "e2b308acfdcf4885acf82db9e0f2c298", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e2b308acfdcf4885acf82db9e0f2c298.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e2b308acfdcf4885acf82db9e0f2c298"}}, "title": "[Covid-19: An ad hoc public health ethics consultation].", "authors": [{"family": "Wild", "given": "Verina", "initials": "V"}, {"family": "Buyx", "given": "Alena", "initials": "A"}, {"family": "Hurst", "given": "Samia", "initials": "S"}, {"family": "Munthe", "given": "Christian", "initials": "C"}, {"family": "Rid", "given": "Annette", "initials": "A"}, {"family": "Schr\u00f6der-B\u00e4ck", "given": "Peter", "initials": "P"}, {"family": "Strech", "given": "Daniel", "initials": "D"}, {"family": "Thompson", "given": "Alison", "initials": "A"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Gesundheitswesen", "issn": "1439-4421", "volume": "82", "issue": "6", "pages": "507-513", "issn-l": null}, "abstract": "In this paper we describe the process and content of our ad hoc public health ethics consultation for a Bavarian health authority in relation to Covid-19.", "doi": "10.1055/a-1174-0086", "pmid": "32604443", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7365938"}], "notes": [], "created": "2020-12-08T15:24:01.743Z", "modified": "2020-12-08T15:24:01.765Z"}, {"entity": "publication", "iuid": "793041f844bb47a6b0459f63b5bf4649", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/793041f844bb47a6b0459f63b5bf4649.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/793041f844bb47a6b0459f63b5bf4649"}}, "title": "Why is COVID-19 so mild in children?", "authors": [{"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6716941376e946289622b5dd86e48acc.json"}}], "type": "editorial", "published": "2020-06-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "issn-l": "0803-5253", "volume": "109", "issue": "6", "pages": "1082-1083"}, "abstract": "Editorial", "doi": "10.1111/apa.15271", "pmid": "32212348", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-04T15:21:26.972Z", "modified": "2021-07-14T07:51:13.276Z"}, {"entity": "publication", "iuid": "f07fdb27688443f7a55e2521ea4aa933", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f07fdb27688443f7a55e2521ea4aa933.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f07fdb27688443f7a55e2521ea4aa933"}}, "title": "The importance of naturally attenuated SARS-CoV-2in the fight against COVID-19.", "authors": [{"family": "Armengaud", "given": "Jean", "initials": "J"}, {"family": "Delaunay-Moisan", "given": "Agn\u00e8s", "initials": "A"}, {"family": "Thuret", "given": "Jean-Yves", "initials": "JY"}, {"family": "van Anken", "given": "Eelco", "initials": "E"}, {"family": "Acosta-Alvear", "given": "Diego", "initials": "D"}, {"family": "Arag\u00f3n", "given": "Tom\u00e1s", "initials": "T"}, {"family": "Arias", "given": "Carolina", "initials": "C"}, {"family": "Blondel", "given": "Marc", "initials": "M"}, {"family": "Braakman", "given": "Ineke", "initials": "I"}, {"family": "Collet", "given": "Jean-Fran\u00e7ois", "initials": "JF"}, {"family": "Courcol", "given": "Ren\u00e9", "initials": "R"}, {"family": "Danchin", "given": "Antoine", "initials": "A"}, {"family": "Deleuze", "given": "Jean-Fran\u00e7ois", "initials": "JF"}, {"family": "Lavigne", "given": "Jean-Philippe", "initials": "JP"}, {"family": "Lucas", "given": "Sophie", "initials": "S"}, {"family": "Michiels", "given": "Thomas", "initials": "T"}, {"family": "Moore", "given": "Edward R B", "initials": "ERB"}, {"family": "Nixon-Abell", "given": "Jonathon", "initials": "J"}, {"family": "Rossello-Mora", "given": "Ramon", "initials": "R"}, {"family": "Shi", "given": "Zheng-Li", "initials": "ZL"}, {"family": "Siccardi", "given": "Antonio G", "initials": "AG"}, {"family": "Sitia", "given": "Roberto", "initials": "R"}, {"family": "Tillett", "given": "Daniel", "initials": "D"}, {"family": "Timmis", "given": "Kenneth N", "initials": "KN"}, {"family": "Toledano", "given": "Michel B", "initials": "MB"}, {"family": "van der Sluijs", "given": "Peter", "initials": "P"}, {"family": "Vicenzi", "given": "Elisa", "initials": "E"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Environ Microbiol", "issn": "1462-2920", "volume": "22", "issue": "6", "pages": "1997-2000", "issn-l": null}, "abstract": "The current SARS-CoV-2 pandemic is wreaking havoc throughout the world and has rapidly become a global health emergency. A central question concerning COVID-19 is why some individuals become sick and others not. Many have pointed already at variation in risk factors between individuals. However, the variable outcome of SARS-CoV-2 infections may, at least in part, be due also to differences between the viral subspecies with which individuals are infected. A more pertinent question is how we are to overcome the current pandemic. A vaccine against SARS-CoV-2 would offer significant relief, although vaccine developers have warned that design, testing and production of vaccines may take a year if not longer. Vaccines are based on a handful of different designs (i), but the earliest vaccines were based on the live, attenuated virus. As has been the case for other viruses during earlier pandemics, SARS-CoV-2 will mutate and may naturally attenuate over time (ii). What makes the current pandemic unique is that, thanks to state-of-the-art nucleic acid sequencing technologies, we can follow in detail how SARS-CoV-2 evolves while it spreads. We argue that knowledge of naturally emerging attenuated SARS-CoV-2 variants across the globe should be of key interest in our fight against the pandemic.", "doi": "10.1111/1462-2920.15039", "pmid": "32342578", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7267670"}], "notes": [], "created": "2020-12-10T07:13:58.995Z", "modified": "2020-12-10T07:14:16.138Z"}, {"entity": "publication", "iuid": "bc62516c1ade4b42900f062d118bf82a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bc62516c1ade4b42900f062d118bf82a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bc62516c1ade4b42900f062d118bf82a"}}, "title": "The disproportionate effect of COVID-19 mortality on ethnic minorities: Genetics or health inequalities?", "authors": [{"family": "El-Khatib", "given": "Ziad", "initials": "Z"}, {"family": "Jacobs", "given": "Graeme Brendon", "initials": "GB"}, {"family": "Ikomey", "given": "George Mondinde", "initials": "GM"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "EClinicalMedicine", "issn": "2589-5370", "volume": "23", "issue": null, "pages": "100430", "issn-l": null}, "abstract": null, "doi": "10.1016/j.eclinm.2020.100430", "pmid": "32572393", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2589-5370(20)30174-7"}, {"db": "pii", "key": "100430"}, {"db": "pmc", "key": "PMC7301807"}], "notes": [], "created": "2020-12-08T16:25:48.111Z", "modified": "2020-12-08T16:25:48.121Z"}, {"entity": "publication", "iuid": "65fdc6954fee4cacbb4b1282ea71421b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/65fdc6954fee4cacbb4b1282ea71421b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/65fdc6954fee4cacbb4b1282ea71421b"}}, "title": "The consequences of the COVID-19 pandemic for self-care in patients supported with a left ventricular assist device.", "authors": [{"family": "Ben Gal", "given": "Tuvia", "initials": "T"}, {"family": "Ben Avraham", "given": "Binyamin", "initials": "B"}, {"family": "Abu-Hazira", "given": "Miriam", "initials": "M"}, {"family": "Frigerio", "given": "Maria", "initials": "M"}, {"family": "Crespo-Leiro", "given": "Maria G", "initials": "MG"}, {"family": "Oppelaar", "given": "Anne Marie", "initials": "AM"}, {"family": "Kato", "given": "Naoko P", "initials": "NP"}, {"family": "Stromberg", "given": "Anna", "initials": "A"}, {"family": "Jaarsma", "given": "Tiny", "initials": "T"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Eur J Heart Fail", "issn": "1879-0844", "volume": "22", "issue": "6", "pages": "933-936", "issn-l": "1388-9842"}, "abstract": null, "doi": "10.1002/ejhf.1868", "pmid": "32391963", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7273102"}], "notes": [], "created": "2020-11-30T09:07:59.472Z", "modified": "2020-11-30T09:07:59.482Z"}, {"entity": "publication", "iuid": "30730f9295124a0ebe25fa06dd1e672e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/30730f9295124a0ebe25fa06dd1e672e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/30730f9295124a0ebe25fa06dd1e672e"}}, "title": "The Role of Pharmacovigilance and ISoP During the Global COVID-19 Pandemic.", "authors": [{"family": "Chandler", "given": "Rebecca E", "initials": "RE"}, {"family": "McCarthy", "given": "Deirdre", "initials": "D"}, {"family": "Delumeau", "given": "Jean-Christophe", "initials": "JC"}, {"family": "Harrison-Woolrych", "given": "Mira", "initials": "M"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Drug Saf", "issn": "1179-1942", "volume": "43", "issue": "6", "pages": "511-512", "issn-l": "0114-5916"}, "abstract": null, "doi": "10.1007/s40264-020-00941-4", "pmid": "32383008", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1007/s40264-020-00941-4"}, {"db": "pmc", "key": "PMC7203700"}], "notes": [], "created": "2020-12-10T07:39:37.185Z", "modified": "2020-12-10T07:44:48.952Z"}, {"entity": "publication", "iuid": "c1839231ec1844ed9ef55d3dc7eaf2fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1839231ec1844ed9ef55d3dc7eaf2fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1839231ec1844ed9ef55d3dc7eaf2fa"}}, "title": "Tackling two pandemics: a plea on World Tuberculosis Day.", "authors": [{"family": "Wingfield", "given": "Tom", "initials": "T"}, {"family": "Cuevas", "given": "Luis E", "initials": "LE"}, {"family": "MacPherson", "given": "Peter", "initials": "P"}, {"family": "Millington", "given": "Kerry A", "initials": "KA"}, {"family": "Squire", "given": "S Bertel", "initials": "SB"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Lancet Respir Med", "issn": "2213-2619", "volume": "8", "issue": "6", "pages": "536-538", "issn-l": "2213-2600"}, "abstract": null, "doi": "10.1016/S2213-2600(20)30151-X", "pmid": "32220280", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2213-2600(20)30151-X"}, {"db": "pmc", "key": "PMC7118542"}], "notes": [], "created": "2020-11-25T07:24:34.379Z", "modified": "2020-12-08T06:57:33.234Z"}, {"entity": "publication", "iuid": "8483b981df644399a2b16f6c0c276fa1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8483b981df644399a2b16f6c0c276fa1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8483b981df644399a2b16f6c0c276fa1"}}, "title": "Systematic review of COVID\u201019 in children shows milder cases and a better prognosis than adults", "authors": [{"family": "Ludvigsson", "given": "Jonas F", "initials": "JF"}], "type": "journal-article", "published": "2020-06-00", "journal": {"title": "Acta Paediatr", "issn": "0803-5253", "volume": "109", "issue": "6", "pages": "1088-1095", "issn-l": null}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic has affected hundreds of thousands of people. Data on symptoms and prognosis in children are rare.\n\nA systematic literature review was carried out to identify papers on COVID-19, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), using the MEDLINE and Embase databases between January 1 and March 18, 2020.\n\nThe search identified 45 relevant scientific papers and letters. The review showed that children have so far accounted for 1%-5% of diagnosed COVID-19 cases, they often have milder disease than adults and deaths have been extremely rare. Diagnostic findings have been similar to adults, with fever and respiratory symptoms being prevalent, but fewer children seem to have developed severe pneumonia. Elevated inflammatory markers were less common in children, and lymphocytopenia seemed rare. Newborn infants have developed symptomatic COVID-19, but evidence of vertical intrauterine transmission was scarce. Suggested treatment included providing oxygen, inhalations, nutritional support and maintaining fluids and electrolyte balances.\n\nThe coronavirus disease 2019 has occurred in children, but they seemed to have a milder disease course and better prognosis than adults. Deaths were extremely rare.", "doi": "10.1111/apa.15270", "pmid": "32202343", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-04T13:20:33.860Z", "modified": "2020-12-10T09:00:20.059Z"}, {"entity": "publication", "iuid": "88f3f44ed037429b84b2679f50149fb2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/88f3f44ed037429b84b2679f50149fb2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/88f3f44ed037429b84b2679f50149fb2"}}, "title": "Surveillance to improve evidence for community control decisions during the COVID-19 pandemic - Opening the animal epidemic toolbox for Public Health.", "authors": [{"family": "Foddai", "given": "Alessandro", "initials": "A"}, {"family": "Lindberg", "given": "Ann", "initials": "A"}, {"family": "Lubroth", "given": "Juan", "initials": "J"}, {"family": "Ellis-Iversen", "given": "Johanne", "initials": "J"}], "type": "editorial", "published": "2020-06-00", "journal": {"title": "One Health", "issn": "2352-7714", "volume": "9", "issue": null, "pages": "100130", "issn-l": "2352-7714"}, "abstract": "During the first few months of 2020, the COVID-19 pandemic reached Europe and spread around the world. Health systems all over the world are trying to control the outbreak in the shortest possible time. Exotic disease outbreaks are not uncommon in animal health and randomised surveillance is frequently used as support for decision-making. This editorial discusses the possibilities of practicing One Health, by using methods from animal health to enhance surveillance for COVID-19 to provide an evidence base fort decision-making in communities and countries.", "doi": "10.1016/j.onehlt.2020.100130", "pmid": "32292816", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2352-7714(20)30046-X"}, {"db": "pii", "key": "100130"}, {"db": "pmc", "key": "PMC7104048"}], "notes": [], "created": "2020-12-09T12:07:55.701Z", "modified": "2020-12-09T12:07:55.711Z"}, {"entity": "publication", "iuid": "d3ccd047985d4acb94bac604fe32433c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d3ccd047985d4acb94bac604fe32433c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d3ccd047985d4acb94bac604fe32433c"}}, "title": "Sleep apnoea management in Europe during the COVID-19 pandemic: data from the European Sleep Apnoea Database (ESADA).", "authors": [{"family": "Grote", "given": "Ludger", "initials": "L"}, {"family": "McNicholas", "given": "Walter T", "initials": "WT"}, {"family": "Hedner", "given": "Jan", "initials": "J"}, {"family": "ESADA collaborators", "given": "", "initials": ""}], "type": "letter", "published": "2020-06-00", "journal": {"title": "Eur Respir J", "issn": "1399-3003", "issn-l": "0903-1936", "volume": "55", "issue": "6", "pages": null}, "abstract": null, "doi": "10.1183/13993003.01323-2020", "pmid": "32366489", "labels": {"Type: Journal article": null, "Category: Other": null, "Category: Social Science & Humanities": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "13993003.01323-2020"}, {"db": "pmc", "key": "PMC7236823"}], "notes": [], "created": "2020-12-10T07:27:06.019Z", "modified": "2022-11-10T07:57:10.670Z"}, {"entity": "publication", "iuid": "84d70442f23c48c0bd1adaf3746235fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/84d70442f23c48c0bd1adaf3746235fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/84d70442f23c48c0bd1adaf3746235fa"}}, "title": "Promoting healthy movement behaviours among children during the COVID-19 pandemic.", "authors": [{"family": "Guan", "given": "Hongyan", "initials": "H"}, {"family": "Okely", "given": "Anthony D", "initials": "AD"}, {"family": "Aguilar-Farias", "given": "Nicolas", "initials": "N"}, {"family": "Del Pozo Cruz", "given": "Borja", "initials": "B"}, {"family": "Draper", "given": "Catherine E", "initials": "CE"}, {"family": "El Hamdouchi", "given": "Asmaa", "initials": "A"}, {"family": "Florindo", "given": "Alex A", "initials": "AA"}, {"family": "J\u00e1uregui", "given": "Alejandra", "initials": "A"}, {"family": "Katzmarzyk", "given": "Peter T", "initials": "PT"}, {"family": "Kontsevaya", "given": "Anna", "initials": "A"}, {"family": "L\u00f6f", "given": "Marie", "initials": "M"}, {"family": "Park", "given": "Wonsoon", "initials": "W"}, {"family": "Reilly", "given": "John J", "initials": "JJ"}, {"family": "Sharma", "given": "Deepika", "initials": "D"}, {"family": "Tremblay", "given": "Mark S", "initials": "MS"}, {"family": "Veldman", "given": "Sanne L C", "initials": "SLC"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Lancet Child Adolesc Health", "issn": "2352-4650", "volume": "4", "issue": "6", "pages": "416-418", "issn-l": null}, "abstract": null, "doi": "10.1016/S2352-4642(20)30131-0", "pmid": "32458805", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2352-4642(20)30131-0"}, {"db": "pmc", "key": "PMC7190292"}], "notes": [], "created": "2020-12-09T11:04:29.834Z", "modified": "2020-12-09T11:04:29.857Z"}, {"entity": "publication", "iuid": "82eecfee1dc44f1384c78e45611f490c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82eecfee1dc44f1384c78e45611f490c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82eecfee1dc44f1384c78e45611f490c"}}, "title": "Population flow drives spatio-temporal distribution of COVID-19 in China.", "authors": [{"family": "Jia", "given": "Jayson S", "initials": "JS"}, {"family": "Lu", "given": "Xin", "initials": "X"}, {"family": "Yuan", "given": "Yun", "initials": "Y"}, {"family": "Xu", "given": "Ge", "initials": "G"}, {"family": "Jia", "given": "Jianmin", "initials": "J"}, {"family": "Christakis", "given": "Nicholas A", "initials": "NA"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "582", "issue": "7812", "pages": "389-394", "issn-l": "0028-0836"}, "abstract": "Sudden, large-scale and diffuse human migration can amplify localized outbreaks of disease into widespread epidemics 1-4. Rapid and accurate tracking of aggregate population flows may therefore be epidemiologically informative. Here we use 11,478,484 counts of mobile phone data from individuals leaving or transiting through the prefecture of Wuhan between 1 January and 24 January 2020 as they moved to 296 prefectures throughout mainland China. First, we document the efficacy of quarantine in ceasing movement. Second, we show that the distribution of population outflow from Wuhan accurately predicts the relative frequency and geographical distribution of infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) until 19 February 2020, across mainland China. Third, we develop a spatio-temporal 'risk source' model that leverages population flow data (which operationalize the risk that emanates from epidemic epicentres) not only to forecast the distribution of confirmed cases, but also to identify regions that have a high risk of transmission at an early stage. Fourth, we use this risk source model to statistically derive the geographical spread of COVID-19 and the growth pattern based on the population outflow from Wuhan; the model yields a benchmark trend and an index for assessing the risk of community transmission of COVID-19 over time for different locations. This approach can be used by policy-makers in any nation with available data to make rapid and accurate risk assessments and to plan the allocation of limited resources ahead of ongoing outbreaks.", "doi": "10.1038/s41586-020-2284-y", "pmid": "32349120", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "URL", "key": "https://static-content.springer.com/esm/art%3A10.1038%2Fs41586-020-2284-y/MediaObjects/41586_2020_2284_MOESM3_ESM.xlsx", "description": "Population outflow data from Wuhan from January 1-24, 2020; COVID-19 case counts as of February 19 and other data for 296 prefectures in mainland China"}], "notes": [], "created": "2020-11-25T07:14:25.611Z", "modified": "2021-02-26T08:45:48.422Z"}, {"entity": "publication", "iuid": "035950dd9daf476c8b949f168f529119", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/035950dd9daf476c8b949f168f529119.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/035950dd9daf476c8b949f168f529119"}}, "title": "Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science.", "authors": [{"family": "Holmes", "given": "Emily A", "initials": "EA"}, {"family": "O'Connor", "given": "Rory C", "initials": "RC"}, {"family": "Perry", "given": "V Hugh", "initials": "VH"}, {"family": "Tracey", "given": "Irene", "initials": "I"}, {"family": "Wessely", "given": "Simon", "initials": "S"}, {"family": "Arseneault", "given": "Louise", "initials": "L"}, {"family": "Ballard", "given": "Clive", "initials": "C"}, {"family": "Christensen", "given": "Helen", "initials": "H"}, {"family": "Cohen Silver", "given": "Roxane", "initials": "R"}, {"family": "Everall", "given": "Ian", "initials": "I"}, {"family": "Ford", "given": "Tamsin", "initials": "T"}, {"family": "John", "given": "Ann", "initials": "A"}, {"family": "Kabir", "given": "Thomas", "initials": "T"}, {"family": "King", "given": "Kate", "initials": "K"}, {"family": "Madan", "given": "Ira", "initials": "I"}, {"family": "Michie", "given": "Susan", "initials": "S"}, {"family": "Przybylski", "given": "Andrew K", "initials": "AK"}, {"family": "Shafran", "given": "Roz", "initials": "R"}, {"family": "Sweeney", "given": "Angela", "initials": "A"}, {"family": "Worthman", "given": "Carol M", "initials": "CM"}, {"family": "Yardley", "given": "Lucy", "initials": "L"}, {"family": "Cowan", "given": "Katherine", "initials": "K"}, {"family": "Cope", "given": "Claire", "initials": "C"}, {"family": "Hotopf", "given": "Matthew", "initials": "M"}, {"family": "Bullmore", "given": "Ed", "initials": "E"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Lancet Psychiatry", "issn": "2215-0374", "volume": "7", "issue": "6", "pages": "547-560", "issn-l": "2215-0366"}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic is having a profound effect on all aspects of society, including mental health and physical health. We explore the psychological, social, and neuroscientific effects of COVID-19 and set out the immediate priorities and longer-term strategies for mental health science research. These priorities were informed by surveys of the public and an expert panel convened by the UK Academy of Medical Sciences and the mental health research charity, MQ: Transforming Mental Health, in the first weeks of the pandemic in the UK in March, 2020. We urge UK research funding agencies to work with researchers, people with lived experience, and others to establish a high level coordination group to ensure that these research priorities are addressed, and to allow new ones to be identified over time. The need to maintain high-quality research standards is imperative. International collaboration and a global perspective will be beneficial. An immediate priority is collecting high-quality data on the mental health effects of the COVID-19 pandemic across the whole population and vulnerable groups, and on brain function, cognition, and mental health of patients with COVID-19. There is an urgent need for research to address how mental health consequences for vulnerable groups can be mitigated under pandemic conditions, and on the impact of repeated media consumption and health messaging around COVID-19. Discovery, evaluation, and refinement of mechanistically driven interventions to address the psychological, social, and neuroscientific aspects of the pandemic are required. Rising to this challenge will require integration across disciplines and sectors, and should be done together with people with lived experience. New funding will be required to meet these priorities, and it can be efficiently leveraged by the UK's world-leading infrastructure. This Position Paper provides a strategy that may be both adapted for, and integrated with, research efforts in other countries.", "doi": "10.1016/S2215-0366(20)30168-1", "pmid": "32304649", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2215-0366(20)30168-1"}, {"db": "pmc", "key": "PMC7159850"}], "notes": [], "created": "2020-11-25T07:16:12.163Z", "modified": "2020-12-09T14:50:53.491Z"}, {"entity": "publication", "iuid": "e92ee2ee22ad4a6182b9acf7f3d86bee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e92ee2ee22ad4a6182b9acf7f3d86bee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e92ee2ee22ad4a6182b9acf7f3d86bee"}}, "title": "Infection prevention guidelines and considerations for paediatric risk groups when reopening primary schools during COVID-19 pandemic, Norway, April 2020.", "authors": [{"family": "Johansen", "given": "Tone Bjordal", "initials": "TB"}, {"family": "Astrup", "given": "Elisabeth", "initials": "E"}, {"family": "Jore", "given": "Solveig", "initials": "S"}, {"family": "Nilssen", "given": "Hege", "initials": "H"}, {"family": "Dahlberg", "given": "Bente Barton", "initials": "BB"}, {"family": "Klingenberg", "given": "Claus", "initials": "C"}, {"family": "Berg", "given": "Are Stuwitz", "initials": "AS"}, {"family": "Greve-Isdahl", "given": "Margrethe", "initials": "M"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "22", "issn-l": null}, "abstract": "In response to the coronavirus disease (COVID-19) pandemic, most countries implemented school closures. In Norway, schools closed on 13 March 2020. The evidence of effect on disease transmission was limited, while negative consequences were evident. Before reopening, risk-assessment for paediatric risk groups was performed, concluding that most children can attend school with few conditions requiring preventative homeschooling. We here present infection prevention and control guidelines for primary schools and recommendations for paediatric risk groups.", "doi": "10.2807/1560-7917.ES.2020.25.22.2000921", "pmid": "32524956", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7336110"}], "notes": [], "created": "2020-12-09T10:08:03.231Z", "modified": "2020-12-09T10:08:17.584Z"}, {"entity": "publication", "iuid": "b9f3736061384153b2c37590835ae09f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9f3736061384153b2c37590835ae09f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9f3736061384153b2c37590835ae09f"}}, "title": "Increased importance of digital medicine and eHealth during the Covid-19 pandemic.", "authors": [{"family": "Thulesius", "given": "Hans", "initials": "H"}], "type": "editorial", "published": "2020-06-00", "journal": {"title": "Scand J Prim Health Care", "issn": "1502-7724", "volume": "38", "issue": "2", "pages": "105-106", "issn-l": null}, "abstract": null, "doi": "10.1080/02813432.2020.1770466", "pmid": "32484725", "labels": {"Type: Other": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2020-12-09T10:54:36.128Z", "modified": "2021-02-26T08:45:48.615Z"}, {"entity": "publication", "iuid": "29f2b116641f4317b6d80f5bda3097b3", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/29f2b116641f4317b6d80f5bda3097b3.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/29f2b116641f4317b6d80f5bda3097b3"}}, "title": "Income security during public health emergencies: the COVID-19 poverty trap in Vietnam.", "authors": [{"family": "Tran", "given": "Phuong Bich", "initials": "PB"}, {"family": "Hensing", "given": "Gunnel", "initials": "G"}, {"family": "Wingfield", "given": "Tom", "initials": "T"}, {"family": "Atkins", "given": "Salla", "initials": "S"}, {"family": "Sidney Annerstedt", "given": "Kristi", "initials": "K"}, {"family": "Kazibwe", "given": "Joseph", "initials": "J"}, {"family": "Tomeny", "given": "Ewan", "initials": "E"}, {"family": "Biermann", "given": "Olivia", "initials": "O"}, {"family": "Thorpe", "given": "Jennifer", "initials": "J"}, {"family": "Forse", "given": "Rachel", "initials": "R"}, {"family": "L\u00f6nnroth", "given": "Knut", "initials": "K"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "5", "issue": "6", "pages": null, "issn-l": "2059-7908"}, "abstract": "Commentary", "doi": "10.1136/bmjgh-2020-002504", "pmid": "32540965", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-002504"}, {"db": "pmc", "key": "PMC7299029"}], "notes": [], "created": "2020-11-25T10:05:13.301Z", "modified": "2020-12-09T07:54:40.461Z"}, {"entity": "publication", "iuid": "958ff2339c9349c9adebb50b167376fa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/958ff2339c9349c9adebb50b167376fa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/958ff2339c9349c9adebb50b167376fa"}}, "title": "Income security during periods of ill health: a scoping review of policies, practice and coverage in low-income and middle-income countries.", "authors": [{"family": "Thorpe", "given": "Jennifer", "initials": "J"}, {"family": "Viney", "given": "Kerri", "initials": "K"}, {"family": "Hensing", "given": "Gunnel", "initials": "G"}, {"family": "L\u00f6nnroth", "given": "Knut", "initials": "K"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "5", "issue": "6", "issn-l": "2059-7908"}, "abstract": "The COVID-19 pandemic is a reminder that insufficient income security in periods of ill health leads to economic hardship for individuals and hampers disease control efforts as people struggle to stay home when sick or advised to observe quarantine. Evidence on income security during periods of ill health is growing but has not previously been reviewed as a full body of work concerning low-income and middle-income countries (LMICs). We performed a scoping review to map the range, features, coverage, protective effects and equity of policies that aim to provide income security for adults whose ill health prevents them from participating in gainful work. A total of 134 studies were included, providing data from 95% of LMICs. However, data across the majority of these countries were severely limited. Collectively the included studies demonstrate that coverage of contributory income-security schemes is low, especially for informal and low-income workers. Meanwhile, non-contributory schemes targeting low-income groups are often not explicitly designed to provide income support in periods of ill health, they can be difficult to access and rarely provide sufficient income support to cover the needs of eligible recipients. While identifying an urgent need for more research on illness-related income security in LMICs, this review concludes that scaling up and diversifying the range of income security interventions is crucial for improving coverage and equity. To achieve these outcomes, illness-related income protection must receive greater recognition in health policy and health financing circles, expanding our understanding of financial hardship beyond direct medical costs.", "doi": "10.1136/bmjgh-2020-002425", "pmid": "32540963", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-002425"}, {"db": "pmc", "key": "PMC7299014"}], "notes": [], "created": "2020-11-25T10:01:53.442Z", "modified": "2020-11-30T08:59:22.813Z"}, {"entity": "publication", "iuid": "601676ec450744c9b10e81a53394376d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/601676ec450744c9b10e81a53394376d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/601676ec450744c9b10e81a53394376d"}}, "title": "ISUOG Safety Committee Position Statement on use of personal protective equipment and hazard mitigation in relation to SARS-CoV-2 for practitioners undertaking obstetric and gynecological ultrasound.", "authors": [{"family": "Abramowicz", "given": "J S", "initials": "JS"}, {"family": "Basseal", "given": "J M", "initials": "JM"}, {"family": "Brezinka", "given": "C", "initials": "C"}, {"family": "Dall'Asta", "given": "A", "initials": "A"}, {"family": "Deng", "given": "J", "initials": "J"}, {"family": "Harrison", "given": "G", "initials": "G"}, {"family": "Lee", "given": "J C S", "initials": "JCS"}, {"family": "Lim", "given": "A", "initials": "A"}, {"family": "Mar\u0161al", "given": "K", "initials": "K"}, {"family": "Miloro", "given": "P", "initials": "P"}, {"family": "Poon", "given": "L C", "initials": "LC"}, {"family": "Salvesen", "given": "K \u00c5", "initials": "K\u00c5"}, {"family": "Sande", "given": "R", "initials": "R"}, {"family": "Ter Haar", "given": "G", "initials": "G"}, {"family": "Westerway", "given": "S C", "initials": "SC"}, {"family": "Xie", "given": "M X", "initials": "MX"}, {"family": "Lees", "given": "C", "initials": "C"}], "type": "consensus development conference", "published": "2020-06-00", "journal": {"title": "Ultrasound Obstet Gynecol", "issn": "1469-0705", "volume": "55", "issue": "6", "pages": "886-891", "issn-l": null}, "abstract": null, "doi": "10.1002/uog.22035", "pmid": "32255535", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7262197"}], "notes": [], "created": "2020-11-30T15:55:40.240Z", "modified": "2020-11-30T15:55:40.263Z"}, {"entity": "publication", "iuid": "1e769a312b144bada7f7438a482e40e2", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/1e769a312b144bada7f7438a482e40e2.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/1e769a312b144bada7f7438a482e40e2"}}, "title": "High impact of COVID-19 in long-term care facilities, suggestion for monitoring in the EU/EEA, May 2020.", "authors": [{"family": "ECDC Public Health Emergency Team", "given": "", "initials": ""}, {"family": "Danis", "given": "Kostas", "initials": "K"}, {"family": "Fonteneau", "given": "Laure", "initials": "L"}, {"family": "Georges", "given": "Scarlett", "initials": "S"}, {"family": "Daniau", "given": "C\u00f4me", "initials": "C"}, {"family": "Bernard-Stoecklin", "given": "Sibylle", "initials": "S"}, {"family": "Domegan", "given": "Lisa", "initials": "L"}, {"family": "O'Donnell", "given": "Joan", "initials": "J"}, {"family": "Hauge", "given": "Siri Helene", "initials": "SH"}, {"family": "Dequeker", "given": "Sara", "initials": "S"}, {"family": "Vandael", "given": "Eline", "initials": "E"}, {"family": "Van der Heyden", "given": "Johan", "initials": "J"}, {"family": "Renard", "given": "Fran\u00e7oise", "initials": "F"}, {"family": "Sierra", "given": "Natalia Bustos", "initials": "NB"}, {"family": "Ricchizzi", "given": "Enrico", "initials": "E"}, {"family": "Schweickert", "given": "Birgitta", "initials": "B"}, {"family": "Schmidt", "given": "Nicole", "initials": "N"}, {"family": "Abu Sin", "given": "Muna", "initials": "M"}, {"family": "Eckmanns", "given": "Tim", "initials": "T"}, {"family": "Paiva", "given": "Jos\u00e9-Artur", "initials": "JA"}, {"family": "Schneider", "given": "Elke", "initials": "E"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "22", "issn-l": null}, "abstract": "Residents in long-term care facilities (LTCF) are a vulnerable population group. Coronavirus disease (COVID-19)-related deaths in LTCF residents represent 30-60% of all COVID-19 deaths in many European countries. This situation demands that countries implement local and national testing, infection prevention and control, and monitoring programmes for COVID-19 in LTCF in order to identify clusters early, decrease the spread within and between facilities and reduce the size and severity of outbreaks.", "doi": "10.2807/1560-7917.ES.2020.25.22.2000956", "pmid": "32524949", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7336111"}], "notes": [], "created": "2020-12-09T10:08:38.057Z", "modified": "2020-12-09T10:08:38.067Z"}, {"entity": "publication", "iuid": "d0916465c57c4e368de76469fa6306d0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d0916465c57c4e368de76469fa6306d0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d0916465c57c4e368de76469fa6306d0"}}, "title": "Guidance for anti-VEGF intravitreal injections during the COVID-19 pandemic.", "authors": [{"family": "Korobelnik", "given": "Jean-Fran\u00e7ois", "initials": "JF"}, {"family": "Loewenstein", "given": "Anat", "initials": "A"}, {"family": "Eldem", "given": "Bora", "initials": "B"}, {"family": "Joussen", "given": "Antonia M", "initials": "AM"}, {"family": "Koh", "given": "Adrian", "initials": "A"}, {"family": "Lambrou", "given": "George N", "initials": "GN"}, {"family": "Lanzetta", "given": "Paolo", "initials": "P"}, {"family": "Li", "given": "Xiaoxin", "initials": "X"}, {"family": "L\u00f6vestam-Adrian", "given": "Monica", "initials": "M"}, {"family": "Navarro", "given": "Rafael", "initials": "R"}, {"family": "Okada", "given": "Annabelle A", "initials": "AA"}, {"family": "Pearce", "given": "Ian", "initials": "I"}, {"family": "Rodr\u00edguez", "given": "Francisco J", "initials": "FJ"}, {"family": "Wong", "given": "David T", "initials": "DT"}, {"family": "Wu", "given": "Lihteh", "initials": "L"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Graefes Arch Clin Exp Ophthalmol", "issn": "1435-702X", "volume": "258", "issue": "6", "pages": "1149-1156", "issn-l": null}, "abstract": "There is an urgent need to address how to best provide ophthalmic care for patients with retinal disease receiving intravitreal injections with anti-vascular endothelial growth factor agents during the ongoing global COVID-19 pandemic. This article provides guidance for ophthalmologists on how to deliver the best possible care for patients while minimizing the risk of infection.\n\nThe Vision Academy's Steering Committee of international retinal disease experts convened to discuss key considerations for managing patients with retinal disease during the COVID-19 pandemic. After reviewing the existing literature on the issue, members put forward recommendations that were systematically refined and voted on to develop this guidance.\n\nThe considerations focus on the implementation of steps to minimize the exposure of patients and healthcare staff to COVID-19. These include the use of personal protective equipment, adherence to scrupulous hygiene and disinfection protocols, pre-screening to identify symptomatic patients, and reducing the number of people in waiting rooms. Other important measures include triaging of patients to identify those at the greatest risk of irreversible vision loss and prioritization of treatment visits over monitoring visits where possible. In order to limit patient exposure, ophthalmologists should refrain from using treatment regimens that require frequent monitoring.\n\nManagement of patients with retinal disease receiving intravitreal injections during the COVID-19 pandemic will require adjustment to regular clinical practice to minimize the risk of exposure of patients and healthcare staff, and to prioritize those with the greatest medical need. The safety of patients and healthcare staff should be of paramount importance in all decision-making.", "doi": "10.1007/s00417-020-04703-x", "pmid": "32328757", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1007/s00417-020-04703-x"}, {"db": "pmc", "key": "PMC7179379"}], "notes": [], "created": "2020-11-30T15:53:13.584Z", "modified": "2020-11-30T15:53:13.608Z"}, {"entity": "publication", "iuid": "091411a45b3043e18f286c3dd9386cab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/091411a45b3043e18f286c3dd9386cab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/091411a45b3043e18f286c3dd9386cab"}}, "title": "From SARS to COVID-19: A previously unknown SARS- related coronavirus (SARS-CoV-2) of pandemic potential infecting humans - Call for a One Health approach.", "authors": [{"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME"}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "One Health", "issn": "2352-7714", "volume": "9", "issue": null, "pages": "100124", "issn-l": "2352-7714"}, "abstract": "Human coronaviruses continue to pose a threat to human health. The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019 which causes coronavirus disease-2019 (COVID-19), an acute respiratory disease marked the third introduction of a highly pathogenic coronavirus into the human population in the twenty-first century. This recent emergence of a previously unknown coronavirus in China leads to huge impacts on humans globally. Covid-19 is a challenge to global public health. Here, we discuss the COVID-19 outbreak in a one health context, highlighting the need for the implementation of one health measures and practices to improve human health and reduce the emergence of pandemic viruses.", "doi": "10.1016/j.onehlt.2020.100124", "pmid": "32195311", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2352-7714(20)30013-6"}, {"db": "pii", "key": "100124"}, {"db": "pmc", "key": "PMC7075990"}], "notes": [], "created": "2020-11-19T14:15:33.908Z", "modified": "2020-12-10T09:03:56.468Z"}, {"entity": "publication", "iuid": "7d9967664a4443e28cf52c8f6bf32d7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7d9967664a4443e28cf52c8f6bf32d7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7d9967664a4443e28cf52c8f6bf32d7a"}}, "title": "Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment.", "authors": [{"family": "Hrusak", "given": "Ondrej", "initials": "O"}, {"family": "Kalina", "given": "Tomas", "initials": "T"}, {"family": "Wolf", "given": "Joshua", "initials": "J"}, {"family": "Balduzzi", "given": "Adriana", "initials": "A"}, {"family": "Provenzi", "given": "Massimo", "initials": "M"}, {"family": "Rizzari", "given": "Carmelo", "initials": "C"}, {"family": "Rives", "given": "Susana", "initials": "S"}, {"family": "Del Pozo Carlavilla", "given": "Mar\u00eda", "initials": "M"}, {"family": "Alonso", "given": "Maria E V", "initials": "MEV"}, {"family": "Dom\u00ednguez-Pinilla", "given": "Nerea", "initials": "N"}, {"family": "Bourquin", "given": "Jean-Pierre", "initials": "JP"}, {"family": "Schmiegelow", "given": "Kjeld", "initials": "K"}, {"family": "Attarbaschi", "given": "Andishe", "initials": "A"}, {"family": "Grillner", "given": "Pernilla", "initials": "P"}, {"family": "Mellgren", "given": "Karin", "initials": "K"}, {"family": "van der Werff Ten Bosch", "given": "Jutte", "initials": "J"}, {"family": "Pieters", "given": "Rob", "initials": "R"}, {"family": "Brozou", "given": "Triantafyllia", "initials": "T"}, {"family": "Borkhardt", "given": "Arndt", "initials": "A"}, {"family": "Escherich", "given": "Gabriele", "initials": "G"}, {"family": "Lauten", "given": "Melchior", "initials": "M"}, {"family": "Stanulla", "given": "Martin", "initials": "M"}, {"family": "Smith", "given": "Owen", "initials": "O"}, {"family": "Yeoh", "given": "Allen E J", "initials": "AEJ"}, {"family": "Elitzur", "given": "Sarah", "initials": "S"}, {"family": "Vora", "given": "Ajay", "initials": "A"}, {"family": "Li", "given": "Chi-Kong", "initials": "CK"}, {"family": "Ariffin", "given": "Hany", "initials": "H"}, {"family": "Kolenova", "given": "Alexandra", "initials": "A"}, {"family": "Dallapozza", "given": "Luciano", "initials": "L"}, {"family": "Farah", "given": "Roula", "initials": "R"}, {"family": "Lazic", "given": "Jelena", "initials": "J"}, {"family": "Manabe", "given": "Atsushi", "initials": "A"}, {"family": "Styczynski", "given": "Jan", "initials": "J"}, {"family": "Kovacs", "given": "Gabor", "initials": "G"}, {"family": "Ottoffy", "given": "Gabor", "initials": "G"}, {"family": "Felice", "given": "Maria S", "initials": "MS"}, {"family": "Buldini", "given": "Barbara", "initials": "B"}, {"family": "Conter", "given": "Valentino", "initials": "V"}, {"family": "Stary", "given": "Jan", "initials": "J"}, {"family": "Schrappe", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Eur J Cancer", "issn": "1879-0852", "volume": "132", "issue": null, "pages": "11-16", "issn-l": "0959-8049"}, "abstract": "Since the beginning of COVID-19 pandemic, it is known that the severe course of the disease occurs mostly among the elderly, whereas it is rare among children and young adults. Comorbidities, in particular, diabetes and hypertension, clearly associated with age, besides obesity and smoke, are strongly associated with the need for intensive treatment and a dismal outcome. A weaker immunity of the elderly has been proposed as a possible explanation of this uneven age distribution. Thus, there is concern that children treated for cancer may allso be at risk for an unfavourable course of infection. Along the same line, anecdotal information from Wuhan, China, mentioned a severe course of COVID-19 in a child treated for leukaemia.\n\nWe made a flash survey on COVID-19 incidence and severity among children on anticancer treatment. Respondents were asked by email to fill in a short Web-based survey.\n\nWe received reports from 25 countries, where approximately 10,000 patients at risk are followed up. At the time of the survey, more than 200 of these children were tested, nine of whom were positive for COVID-19. Eight of the nine cases had asymptomatic to mild disease, and one was just diagnosed with COVID-19. We also discuss preventive measures that are in place or should be taken and treatment options in immunocompromised children with COVID-19.\n\nThus, even children receiving anticancer chemotherapy may have a mild or asymptomatic course of COVID-19. While we should not underestimate the risk of developing a more severe course of COVID-19 than that observed here, the intensity of preventive measures should not cause delays or obstructions in oncological treatment.", "doi": "10.1016/j.ejca.2020.03.021", "pmid": "32305831", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0959-8049(20)30162-3"}, {"db": "pmc", "key": "PMC7141482"}], "notes": [], "created": "2020-11-23T11:40:21.856Z", "modified": "2020-12-09T14:50:34.476Z"}, {"entity": "publication", "iuid": "8380e9f6f24d407083dc596516f81b09", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8380e9f6f24d407083dc596516f81b09.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8380e9f6f24d407083dc596516f81b09"}}, "title": "Festina lente: hydroxychloroquine, COVID-19 and the role of the rheumatologist.", "authors": [{"family": "Graef", "given": "Elizabeth R", "initials": "ER"}, {"family": "Liew", "given": "Jean W", "initials": "JW"}, {"family": "Putman", "given": "Michael S", "initials": "MS"}, {"family": "Simard", "given": "Julia F", "initials": "JF"}, {"family": "Sirotich", "given": "Emily", "initials": "E"}, {"family": "Berenbaum", "given": "Francis", "initials": "F"}, {"family": "Duarte-Garc\u00eda", "given": "Al\u00ed", "initials": "A"}, {"family": "Grainger", "given": "Rebecca", "initials": "R"}, {"family": "Harrison", "given": "Carly", "initials": "C"}, {"family": "Konig", "given": "Maximilian F", "initials": "MF"}, {"family": "Korsten", "given": "Peter", "initials": "P"}, {"family": "Proulx", "given": "Laurie", "initials": "L"}, {"family": "Richards", "given": "Dawn P", "initials": "DP"}, {"family": "Robinson", "given": "Philip C", "initials": "PC"}, {"family": "Sattui", "given": "Sebastian E", "initials": "SE"}, {"family": "Ugarte-Gil", "given": "Manuel Francisco", "initials": "MF"}, {"family": "Young", "given": "Kristen J", "initials": "KJ"}, {"family": "Kim", "given": "Alfred Hj", "initials": "AH"}, {"family": "Sparks", "given": "Jeffrey A", "initials": "JA"}, {"family": "COVID-19 Global Rheumatology Alliance", "given": "", "initials": ""}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Ann Rheum Dis", "issn": "1468-2060", "volume": "79", "issue": "6", "pages": "734-736", "issn-l": null}, "abstract": null, "doi": "10.1136/annrheumdis-2020-217480", "pmid": "32295786", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "annrheumdis-2020-217480"}, {"db": "pmc", "key": "PMC7359879"}, {"db": "mid", "key": "NIHMS1606969"}], "notes": [], "created": "2020-11-30T15:55:37.866Z", "modified": "2020-11-30T15:55:37.889Z"}, {"entity": "publication", "iuid": "c3cc1bf8901d417ba85873a09063b21e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c3cc1bf8901d417ba85873a09063b21e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c3cc1bf8901d417ba85873a09063b21e"}}, "title": "European Task Force on Atopic Dermatitis statement on severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection and atopic dermatitis.", "authors": [{"family": "Wollenberg", "given": "A", "initials": "A"}, {"family": "Flohr", "given": "C", "initials": "C"}, {"family": "Simon", "given": "D", "initials": "D"}, {"family": "Cork", "given": "M J", "initials": "MJ"}, {"family": "Thyssen", "given": "J P", "initials": "JP"}, {"family": "Bieber", "given": "T", "initials": "T"}, {"family": "de Bruin-Weller", "given": "M S", "initials": "MS"}, {"family": "Weidinger", "given": "S", "initials": "S"}, {"family": "Deleuran", "given": "M", "initials": "M"}, {"family": "Taieb", "given": "A", "initials": "A"}, {"family": "Paul", "given": "C", "initials": "C"}, {"family": "Trzeciak", "given": "M", "initials": "M"}, {"family": "Werfel", "given": "T", "initials": "T"}, {"family": "Seneschal", "given": "J", "initials": "J"}, {"family": "Barbarot", "given": "S", "initials": "S"}, {"family": "Darsow", "given": "U", "initials": "U"}, {"family": "Torrelo", "given": "A", "initials": "A"}, {"family": "Stalder", "given": "J-F", "initials": "JF"}, {"family": "Svensson", "given": "\u00c5", "initials": "\u00c5"}, {"family": "Hijnen", "given": "D", "initials": "D"}, {"family": "Gelmetti", "given": "C", "initials": "C"}, {"family": "Szalai", "given": "Z", "initials": "Z"}, {"family": "Gieler", "given": "U", "initials": "U"}, {"family": "De Raeve", "given": "L", "initials": "L"}, {"family": "Kunz", "given": "B", "initials": "B"}, {"family": "Spuls", "given": "P", "initials": "P"}, {"family": "von Kobyletzki", "given": "L B", "initials": "LB"}, {"family": "F\u00f6lster-Holst", "given": "R", "initials": "R"}, {"family": "Chernyshov", "given": "P V", "initials": "PV"}, {"family": "Christen-Zaech", "given": "S", "initials": "S"}, {"family": "Heratizadeh", "given": "A", "initials": "A"}, {"family": "Ring", "given": "J", "initials": "J"}, {"family": "Vestergaard", "given": "C", "initials": "C"}], "type": "letter", "published": "2020-06-00", "journal": {"title": "J Eur Acad Dermatol Venereol", "issn": "1468-3083", "volume": "34", "issue": "6", "pages": "e241-e242", "issn-l": null}, "abstract": null, "doi": "10.1111/jdv.16411", "pmid": "32223003", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-30T16:01:49.309Z", "modified": "2020-12-08T06:58:52.882Z"}, {"entity": "publication", "iuid": "f5f143610ed24ce6b388a493421004cc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f5f143610ed24ce6b388a493421004cc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f5f143610ed24ce6b388a493421004cc"}}, "title": "European Society of Minimally Invasive Neurological Therapy (ESMINT) recommendations for optimal interventional neurovascular management in the COVID-19 era.", "authors": [{"family": "Aggour", "given": "Mohamed", "initials": "M"}, {"family": "White", "given": "Phil", "initials": "P"}, {"family": "Kulcsar", "given": "Zsolt", "initials": "Z"}, {"family": "Fiehler", "given": "Jens", "initials": "J"}, {"family": "Brouwer", "given": "Patrick", "initials": "P"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "J Neurointerv Surg", "issn": "1759-8486", "volume": "12", "issue": "6", "pages": "542-544", "issn-l": "1759-8478"}, "abstract": null, "doi": "10.1136/neurintsurg-2020-016137", "pmid": "32303584", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "neurintsurg-2020-016137"}], "notes": [], "created": "2020-11-23T11:37:35.344Z", "modified": "2020-11-30T15:55:36.757Z"}, {"entity": "publication", "iuid": "11edc1b3690e4b4389108f054457a93d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/11edc1b3690e4b4389108f054457a93d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/11edc1b3690e4b4389108f054457a93d"}}, "title": "Drought and COVID-19 in the Eastern Mediterranean Region of the WHO.", "authors": [{"family": "Bellizzi", "given": "S", "initials": "S"}, {"family": "Panu Napodano", "given": "C M", "initials": "CM"}, {"family": "Fiamma", "given": "M", "initials": "M"}, {"family": "Ali Maher", "given": "O", "initials": "O"}], "type": "letter", "published": "2020-06-00", "journal": {"title": "Public Health", "issn": "1476-5616", "volume": "183", "issue": null, "pages": "46-47", "issn-l": null}, "abstract": null, "doi": "10.1016/j.puhe.2020.04.032", "pmid": "32422440", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0033-3506(20)30137-2"}, {"db": "pmc", "key": "PMC7205725"}], "notes": [], "created": "2020-12-09T11:45:41.328Z", "modified": "2020-12-09T11:45:41.338Z"}, {"entity": "publication", "iuid": "c39d8c784a284e0a9e934ca3053fcca1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c39d8c784a284e0a9e934ca3053fcca1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c39d8c784a284e0a9e934ca3053fcca1"}}, "title": "Diagnostic and digital solutions to address the COVID-19 pandemic: The need for international collaboration to close the gap.", "authors": [{"family": "Kyhlstedt", "given": "Mattias", "initials": "M"}, {"family": "Andersson", "given": "Sarah Wamala", "initials": "SW"}], "type": "editorial", "published": "2020-06-00", "journal": {"title": "Health Policy Technol", "issn": "2211-8837", "volume": "9", "issue": "2", "pages": "126-128", "issn-l": null}, "abstract": null, "doi": "10.1016/j.hlpt.2020.04.010", "pmid": "32341908", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2211-8837(20)30045-9"}, {"db": "pmc", "key": "PMC7182749"}], "notes": [], "created": "2020-12-10T07:11:46.097Z", "modified": "2020-12-10T07:12:14.626Z"}, {"entity": "publication", "iuid": "3395e910fcf34fa895cd0fc21ca7741d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3395e910fcf34fa895cd0fc21ca7741d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3395e910fcf34fa895cd0fc21ca7741d"}}, "title": "Chronic Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers Is High Among Intensive Care Unit Patients With Non-COVID-19 Sepsis but Carries a Moderately Increased Risk of Death.", "authors": [{"family": "Sunden-Cullberg", "given": "Jonas", "initials": "J"}], "type": "letter", "published": "2020-06-00", "journal": {"title": "Hypertension", "issn": "1524-4563", "volume": "75", "issue": "6", "pages": "e15-e16", "issn-l": "0194-911X"}, "abstract": "Comment", "doi": "10.1161/HYPERTENSIONAHA.120.15178", "pmid": "32275190", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7188028"}], "notes": [], "created": "2020-11-23T11:26:27.056Z", "modified": "2020-12-09T12:06:04.563Z"}, {"entity": "publication", "iuid": "fa6f8658e56447dd96deb89d7f60a796", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fa6f8658e56447dd96deb89d7f60a796.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fa6f8658e56447dd96deb89d7f60a796"}}, "title": "COVID-19 pandemic: Effects and evidence-based recommendations for otolaryngology and head and neck surgery practice.", "authors": [{"family": "Kowalski", "given": "Luiz P", "initials": "LP"}, {"family": "Sanabria", "given": "Alvaro", "initials": "A"}, {"family": "Ridge", "given": "John A", "initials": "JA"}, {"family": "Ng", "given": "Wai Tong", "initials": "WT"}, {"family": "de Bree", "given": "Remco", "initials": "R"}, {"family": "Rinaldo", "given": "Alessandra", "initials": "A"}, {"family": "Takes", "given": "Robert P", "initials": "RP"}, {"family": "M\u00e4kitie", "given": "Antti A", "initials": "AA"}, {"family": "Carvalho", "given": "Andre L", "initials": "AL"}, {"family": "Bradford", "given": "Carol R", "initials": "CR"}, {"family": "Paleri", "given": "Vinidh", "initials": "V"}, {"family": "Hartl", "given": "Dana M", "initials": "DM"}, {"family": "Vander Poorten", "given": "Vincent", "initials": "V"}, {"family": "Nixon", "given": "Iain J", "initials": "IJ"}, {"family": "Piazza", "given": "Cesare", "initials": "C"}, {"family": "Lacy", "given": "Peter D", "initials": "PD"}, {"family": "Rodrigo", "given": "Juan P", "initials": "JP"}, {"family": "Guntinas-Lichius", "given": "Orlando", "initials": "O"}, {"family": "Mendenhall", "given": "William M", "initials": "WM"}, {"family": "D'Cruz", "given": "Anil", "initials": "A"}, {"family": "Lee", "given": "Anne W M", "initials": "AWM"}, {"family": "Ferlito", "given": "Alfio", "initials": "A"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Head Neck", "issn": "1097-0347", "volume": "42", "issue": "6", "pages": "1259-1267", "issn-l": "1043-3074"}, "abstract": "The 2019 novel coronavirus disease (COVID-19) is a highly contagious zoonosis produced by SARS-CoV-2 that is spread human-to-human by respiratory secretions. It was declared by the WHO as a public health emergency. The most susceptible populations, needing mechanical ventilation, are the elderly and people with associated comorbidities. There is an important risk of contagion for anesthetists, dentists, head and neck surgeons, maxillofacial surgeons, ophthalmologists, and otolaryngologists. Health workers represent between 3.8% and 20% of the infected population; some 15% will develop severe complaints and among them, many will lose their lives. A large number of patients do not have overt signs and symptoms (fever/respiratory), yet pose a real risk to surgeons (who should know this fact and must therefore apply respiratory protective strategies for all patients they encounter). All interventions that have the potential to aerosolize aerodigestive secretions should be avoided or used only when mandatory. Health workers who are: pregnant, over 55 to 65 years of age, with a history of chronic diseases (uncontrolled hypertension, diabetes mellitus, chronic obstructive pulmonary diseases, and all clinical scenarios where immunosuppression is feasible, including that induced to treat chronic inflammatory conditions and organ transplants) should avoid the clinical attention of a potentially infected patient. Health care facilities should prioritize urgent and emergency visits and procedures until the present condition stabilizes; truly elective care should cease and discussed on a case-by-case basis for patients with cancer. For those who are working with COVID-19 infected patients' isolation is compulsory in the following settings: (a) unprotected close contact with COVID-19 pneumonia patients; (b) onset of fever, cough, shortness of breath, and other symptoms (gastrointestinal complaints, anosmia, and dysgeusia have been reported in a minority of cases). For any care or intervention in the upper aerodigestive tract region, irrespective of the setting and a confirmed diagnosis (eg, rhinoscopy or flexible laryngoscopy in the outpatient setting and tracheostomy or rigid endoscopy under anesthesia), it is strongly recommended that all health care personnel wear personal protective equipment such as N95, gown, cap, eye protection, and gloves. The procedures described are essential in trying to maintain safety of health care workers during COVID-19 pandemic. In particular, otolaryngologists, head and neck, and maxillofacial surgeons are per se exposed to the greatest risk of infection while caring for COVID-19 positive subjects, and their protection should be considered a priority in the present circumstances.", "doi": "10.1002/hed.26164", "pmid": "32270581", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7262203"}], "notes": [], "created": "2020-11-22T17:13:43.745Z", "modified": "2021-02-26T08:45:48.906Z"}, {"entity": "publication", "iuid": "53949d8569d644fea43526782295763e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/53949d8569d644fea43526782295763e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/53949d8569d644fea43526782295763e"}}, "title": "COVID-19 and urology: a comprehensive review of the literature.", "authors": [{"family": "Puliatti", "given": "Stefano", "initials": "S"}, {"family": "Eissa", "given": "Ahmed", "initials": "A"}, {"family": "Eissa", "given": "Radwa", "initials": "R"}, {"family": "Amato", "given": "Marco", "initials": "M"}, {"family": "Mazzone", "given": "Elio", "initials": "E"}, {"family": "Dell'Oglio", "given": "Paolo", "initials": "P"}, {"family": "Sighinolfi", "given": "Maria Chiara", "initials": "MC"}, {"family": "Zoeir", "given": "Ahmed", "initials": "A"}, {"family": "Micali", "given": "Salvatore", "initials": "S"}, {"family": "Bianchi", "given": "Giampaolo", "initials": "G"}, {"family": "Patel", "given": "Vipul", "initials": "V"}, {"family": "Wiklund", "given": "Peter", "initials": "P"}, {"family": "Coelho", "given": "Rafael F", "initials": "RF"}, {"family": "Bernhard", "given": "Jean-Christophe", "initials": "JC"}, {"family": "Dasgupta", "given": "Prokar", "initials": "P"}, {"family": "Mottrie", "given": "Alexandre", "initials": "A"}, {"family": "Rocco", "given": "Bernardo", "initials": "B"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "BJU Int", "issn": "1464-410X", "volume": "125", "issue": "6", "pages": "E7-E14", "issn-l": "1464-4096"}, "abstract": "To discuss the impact of COVID-19 on global health, particularly on urological practice and to review some of the available recommendations reported in the literature.\n\nIn the current narrative review the PubMed database was searched to identify all the related reports discussing the impact of COVID-19 on the urological field.\n\nThe COVID-19 pandemic is the latest and biggest global health threat. Medical and surgical priorities have changed dramatically to cope with the current challenge. These changes include postponements of all elective outpatient visits and surgical procedures to save facilities and resources for urgent cases and patients with COVID-19 patients. This review discuss some of the related changes in urology.\n\nOver the coming weeks, healthcare workers including urologists will be facing increasingly difficult challenges, and consequently, they should adopt triage strategy to avoid wasting of medical resources and they should endorse sufficient protection policies to guard against infection when dealing with COVID-19 patients.", "doi": "10.1111/bju.15071", "pmid": "32249538", "labels": {"Type: Review": null}, "xrefs": [], "notes": [], "created": "2020-11-22T17:05:52.843Z", "modified": "2020-12-09T11:49:47.884Z"}, {"entity": "publication", "iuid": "26126d85d88b4bfbb806f5648b298c2b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/26126d85d88b4bfbb806f5648b298c2b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/26126d85d88b4bfbb806f5648b298c2b"}}, "title": "COVID-19 and the policy sciences: initial reactions and perspectives", "authors": [{"family": "Weible", "given": "Christopher M", "initials": "CM"}, {"family": "Nohrstedt", "given": "Daniel", "initials": "D"}, {"family": "Cairney", "given": "Paul", "initials": "P"}, {"family": "Carter", "given": "David P", "initials": "DP"}, {"family": "Crow", "given": "Deserai A", "initials": "DA"}, {"family": "Durnov\u00e1", "given": "Anna P", "initials": "AP"}, {"family": "Heikkila", "given": "Tanya", "initials": "T"}, {"family": "Ingold", "given": "Karin", "initials": "K"}, {"family": "McConnell", "given": "Allan", "initials": "A"}, {"family": "Stone", "given": "Diane", "initials": "D"}], "type": "journal-article", "published": "2020-06-00", "journal": {"title": "Policy Sci", "issn": "0032-2687", "volume": "53", "issue": "2", "pages": "225-241", "issn-l": null}, "abstract": "The world is in the grip of a crisis that stands unprecedented in living memory. The COVID-19 pandemic is urgent, global in scale, and massive in impacts. Following Harold D. Lasswell's goal for the policy sciences to offer insights into unfolding phenomena, this commentary draws on the lessons of the policy sciences literature to understand the dynamics related to COVID-19. We explore the ways in which scientific and technical expertise, emotions, and narratives influence policy decisions and shape relationships among citizens, organizations, and governments. We discuss varied processes of adaptation and change, including learning, surges in policy responses, alterations in networks (locally and globally), implementing policies across transboundary issues, and assessing policy success and failure. We conclude by identifying understudied aspects of the policy sciences that deserve attention in the pandemic's aftermath.", "doi": "10.1007/s11077-020-09381-4", "pmid": "32313308", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "9381"}, {"db": "pmc", "key": "PMC7165254"}], "notes": [], "created": "2020-12-09T14:51:20.654Z", "modified": "2021-12-06T12:55:45.743Z"}, {"entity": "publication", "iuid": "e3b44608bd1a49b48f775d1281f565e6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e3b44608bd1a49b48f775d1281f565e6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e3b44608bd1a49b48f775d1281f565e6"}}, "title": "A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection", "authors": [{"family": "Casanova", "given": "Jean Laurent", "initials": "JL"}, {"family": "Su", "given": "Helen C", "initials": "HC"}, {"family": "Abel", "given": "Laurent", "initials": "L"}, {"family": "Aiuti", "given": "Alessandro", "initials": "A"}, {"family": "Almuhsen", "given": "Saleh", "initials": "S"}, {"family": "Arias", "given": "Andres Augusto", "initials": "AA"}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Biggs", "given": "Catherine", "initials": "C"}, {"family": "Bogunovic", "given": "Dusan", "initials": "D"}, {"family": "Boisson", "given": "Bertrand", "initials": "B"}, {"family": "Boisson-Dupuis", "given": "Stephanie", "initials": "S"}, {"family": "Bolze", "given": "Alexandre", "initials": "A"}, {"family": "Bondarenko", "given": "Anastasia", "initials": "A"}, {"family": "Bousfiha", "given": "Aziz", "initials": "A"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "Bustamante", "given": "Jacinta", "initials": "J"}, {"family": "Butte", "given": "Manish", "initials": "M"}, {"family": "Casari", "given": "Giorgio", "initials": "G"}, {"family": "Ciancanelli", "given": "Michael", "initials": "M"}, {"family": "Cobat", "given": "Aurelie", "initials": "A"}, {"family": "Condino-Neto", "given": "Antonio", "initials": "A"}, {"family": "Cooper", "given": "Megan", "initials": "M"}, {"family": "Dalgard", "given": "Clifton", "initials": "C"}, {"family": "Espinosa", "given": "Sara", "initials": "S"}, {"family": "Feldman", "given": "Hagit", "initials": "H"}, {"family": "Fellay", "given": "Jacques", "initials": "J"}, {"family": "Franco", "given": "Jose Luis", "initials": "JL"}, {"family": "Hagin", "given": "David", "initials": "D"}, {"family": "Itan", "given": "Yuval", "initials": "Y"}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E"}, {"family": "Lucas", "given": "Carrie", "initials": "C"}, {"family": "Mansouri", "given": "Davood", "initials": "D"}, {"family": "Meyts", "given": "Isabelle", "initials": "I"}, {"family": "Milner", "given": "Joshua", "initials": "J"}, {"family": "Mogensen", "given": "Trine", "initials": "T"}, {"family": "Morio", "given": "Tomohiro", "initials": "T"}, {"family": "Ng", "given": "Lisa", "initials": "L"}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD"}, {"family": "Okada", "given": "Satoshi", "initials": "S"}, {"family": "Ozcelik", "given": "Tayfun", "initials": "T"}, {"family": "Soler Palac\u00edn", "given": "Pere", "initials": "P"}, {"family": "Planas", "given": "Anna", "initials": "A"}, {"family": "Prando", "given": "Carolina", "initials": "C"}, {"family": "Puel", "given": "Anne", "initials": "A"}, {"family": "Pujol", "given": "Aurora", "initials": "A"}, {"family": "Redin", "given": "Claire", "initials": "C"}, {"family": "Renia", "given": "Laurent", "initials": "L"}, {"family": "Rodriguez Gallego", "given": "Jose Carlos", "initials": "JC"}, {"family": "Quintana-Murci", "given": "Lluis", "initials": "L"}, {"family": "Sancho-Shimizu", "given": "Vanessa", "initials": "V"}, {"family": "Sankaran", "given": "Vijay", "initials": "V"}, {"family": "Sepp\u00e4nen", "given": "Mikko R J", "initials": "MRJ"}, {"family": "Shahrooei", "given": "Mohammad", "initials": "M"}, {"family": "Snow", "given": "Andrew", "initials": "A"}, {"family": "Spaan", "given": "Andr\u00e1s", "initials": "A"}, {"family": "Tangye", "given": "Stuart", "initials": "S"}, {"family": "Tur", "given": "Jordi Perez", "initials": "JP"}, {"family": "Turvey", "given": "Stuart", "initials": "S"}, {"family": "Vinh", "given": "Donald C", "initials": "DC"}, {"family": "von Bernuth", "given": "Horst", "initials": "H"}, {"family": "Wang", "given": "Xiaochuan", "initials": "X"}, {"family": "Zawadzki", "given": "Pawel", "initials": "P"}, {"family": "Zhang", "given": "Qian", "initials": "Q"}, {"family": "Zhang", "given": "Shenying", "initials": "S"}], "type": "journal-article", "published": "2020-06-00", "journal": {"title": "Cell", "issn": "0092-8674", "issn-l": null, "volume": "181", "issue": "6", "pages": "1194-1199"}, "abstract": null, "doi": "10.1016/j.cell.2020.05.016", "pmid": null, "labels": {"Type: Journal article": null, "Category: Genomics & transcriptomics": null}, "xrefs": [], "notes": [], "created": "2021-01-08T14:42:51.655Z", "modified": "2021-02-26T08:45:14.484Z"}, {"entity": "publication", "iuid": "c1a203b527b147eb9c8b072439cb950d", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1a203b527b147eb9c8b072439cb950d.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1a203b527b147eb9c8b072439cb950d"}}, "title": "COVID-19 Pandemic: What Can the West Learn From the East?", "authors": [{"family": "Shokoohi", "given": "Mostafa", "initials": "M"}, {"family": "Osooli", "given": "Mehdi", "initials": "M"}, {"family": "Stranges", "given": "Saverio", "initials": "S"}], "type": "journal article", "published": "2020-05-31", "journal": {"title": "Int J Health Policy Manag", "issn": "2322-5939", "volume": null, "issue": null, "issn-l": null}, "abstract": "Differences in public health approaches to control the coronavirus disease 2019 (COVID-19) pandemic could largely explain substantial variations in epidemiological indicators (such as incidence and mortality) between the West and the East. COVID-19 revealed vulnerabilities of most western countries' healthcare systems in their response to the ongoing public health crisis. Hence, western countries can possibly learn from practices from several East Asian countries regarding infrastructures, epidemiological surveillance and control strategies to mitigate the public health impact of the pandemic. In this paper, we discuss that the lack of rapid and timely community-centered approaches, and most importantly weak public health infrastructures, might have resulted in a high number of infected cases and fatalities in many western countries.", "doi": "10.34172/ijhpm.2020.85", "pmid": "32610736", "labels": {"Type: Journal article": null}, "xrefs": [], "notes": [], "created": "2020-12-08T15:21:17.919Z", "modified": "2020-12-08T15:21:17.941Z"}, {"entity": "publication", "iuid": "2d3174860b5c42748add3b95c71de385", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2d3174860b5c42748add3b95c71de385.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2d3174860b5c42748add3b95c71de385"}}, "title": "The invisible pandemic.", "authors": [{"family": "Giesecke", "given": "Johan", "initials": "J"}], "type": "letter", "published": "2020-05-30", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "395", "issue": "10238", "pages": "e98", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)31035-7", "pmid": "32539940", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)31035-7"}, {"db": "pmc", "key": "PMC7200128"}], "notes": [], "created": "2020-11-25T10:01:09.416Z", "modified": "2020-12-09T07:55:20.718Z"}, {"entity": "publication", "iuid": "f7811fd8913f43e78c16e387fc37e5f0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7811fd8913f43e78c16e387fc37e5f0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7811fd8913f43e78c16e387fc37e5f0"}}, "title": "Low prevalence of SARS-CoV-2 among pregnant and postpartum patients with universal screening in Seattle, Washington.", "authors": [{"family": "LaCourse", "given": "Sylvia M", "initials": "SM"}, {"family": "Kachikis", "given": "Alisa", "initials": "A"}, {"family": "Blain", "given": "Michela", "initials": "M"}, {"family": "Simmons", "given": "LaVone E", "initials": "LE"}, {"family": "Mays", "given": "James A", "initials": "JA"}, {"family": "Pattison", "given": "Amber D", "initials": "AD"}, {"family": "Salerno", "given": "Carol C", "initials": "CC"}, {"family": "McCartney", "given": "Stephen A", "initials": "SA"}, {"family": "Kretzer", "given": "Nicole M", "initials": "NM"}, {"family": "Resnick", "given": "Rebecca", "initials": "R"}, {"family": "Shay", "given": "Rosemary L", "initials": "RL"}, {"family": "Savitsky", "given": "Leah M", "initials": "LM"}, {"family": "Curtin", "given": "Anna C", "initials": "AC"}, {"family": "Huebner", "given": "Emily M", "initials": "EM"}, {"family": "Ma", "given": "Kimberly K", "initials": "KK"}, {"family": "Delaney", "given": "Shani", "initials": "S"}, {"family": "Delgado", "given": "Carlos", "initials": "C"}, {"family": "Schippers", "given": "Adrienne", "initials": "A"}, {"family": "Munson", "given": "Jeff", "initials": "J"}, {"family": "Pottinger", "given": "Paul S", "initials": "PS"}, {"family": "Cohen", "given": "Seth", "initials": "S"}, {"family": "Neme", "given": "Santiago", "initials": "S"}, {"family": "Bourassa", "given": "Lori", "initials": "L"}, {"family": "Bryan", "given": "Andrew", "initials": "A"}, {"family": "Greninger", "given": "Alex", "initials": "A"}, {"family": "Jerome", "given": "Keith R", "initials": "KR"}, {"family": "Roxby", "given": "Alison C", "initials": "AC"}, {"family": "Lokken", "given": "Erica", "initials": "E"}, {"family": "Cheng", "given": "Edith", "initials": "E"}, {"family": "Adams Waldorf", "given": "Kristina M", "initials": "KM"}, {"family": "Hitti", "given": "Jane", "initials": "J"}], "type": "journal article", "published": "2020-05-30", "journal": {"title": "Clin Infect Dis", "issn": "1537-6591", "volume": null, "issue": null, "issn-l": "1058-4838"}, "abstract": "We found a low prevalence of SARS-CoV-2 (2.7% [5/188]) among pregnant and postpartum patients after initiating universal testing. Prevalence among symptomatic patients (22.2% [4/18]) was similar to initial targeted screening approaches (19.1% [8/42]). Among 170 asymptomatic patients, two were positive or inconclusive, respectively; repeat testing at 24 hours was negative.", "doi": "10.1093/cid/ciaa675", "pmid": "32472688", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "5848913"}, {"db": "pmc", "key": "PMC7314151"}], "notes": [], "created": "2020-12-09T11:02:45.999Z", "modified": "2021-02-26T08:45:48.879Z"}, {"entity": "publication", "iuid": "619f0e5a1caf46a19db29becd97df2c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/619f0e5a1caf46a19db29becd97df2c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/619f0e5a1caf46a19db29becd97df2c9"}}, "title": "Effect of COVID-19 response in Uganda on street children", "authors": [{"family": "Kawala", "given": "Brenda Allen", "initials": "BA"}, {"family": "Kirui", "given": "Brian Kibiwott", "initials": "BK"}, {"family": "Cumber", "given": "Samuel Nambile", "initials": "SN"}], "type": "journal-article", "published": "2020-05-29", "journal": {"title": "Pan Afr Med J", "issn": "1937-8688", "volume": "35", "issue": "Supp 2", "pages": "56", "issn-l": null}, "abstract": null, "doi": "10.11604/pamj.supp.2020.35.2.23545", "pmid": "33623581", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2021-02-25T10:10:48.886Z", "modified": "2021-02-25T10:11:23.119Z"}, {"entity": "publication", "iuid": "71cc0f9b690a4930a5aa7d9d71e51587", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/71cc0f9b690a4930a5aa7d9d71e51587.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/71cc0f9b690a4930a5aa7d9d71e51587"}}, "title": "Assessing Psychological Response to the COVID-19: The Fear of COVID-19 Scale and the COVID Stress Scales.", "authors": [{"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Lin", "given": "Chung-Ying", "initials": "CY"}], "type": "journal article", "published": "2020-05-29", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "volume": null, "issue": null, "pages": "1-4", "issn-l": null}, "abstract": null, "doi": "10.1007/s11469-020-00334-9", "pmid": "32837424", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "334"}, {"db": "pmc", "key": "PMC7259433"}], "notes": [], "created": "2020-12-07T10:36:43.662Z", "modified": "2020-12-07T10:36:43.672Z"}, {"entity": "publication", "iuid": "0920ab25f86e4d27a1b9f3378fa735b8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0920ab25f86e4d27a1b9f3378fa735b8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0920ab25f86e4d27a1b9f3378fa735b8"}}, "title": "Serological tests should be related to the aim of the testing, as well as the population.", "authors": [{"family": "Modig", "given": "Karin", "initials": "K"}, {"family": "Gem\u00e9s", "given": "Katalin", "initials": "K"}, {"family": "Feychting", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2020-05-27", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": "Expectations are high on serological tests for SARS-CoV-2. Further knowledge of the immunity is needed, but also evaluation of the reliability of the tests. Important for the latter is for which purpose the test is conducted and how common the outcome to be identified is (antibodies). For the determination of immunity at the individual level, the specificity of the test must be very high, preferably 100%. Even tests where the specificity is perceived as high, e.g. 95% or 99%, can lead to a large proportion of false positives, if the proportion of the population actually infected is small.", "doi": null, "pmid": "32463477", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "20081"}], "notes": [], "created": "2020-11-25T08:22:02.643Z", "modified": "2023-06-19T14:48:59.968Z"}, {"entity": "publication", "iuid": "a9b5a357258d4cec9ee60f09d0a2dc3b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a9b5a357258d4cec9ee60f09d0a2dc3b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a9b5a357258d4cec9ee60f09d0a2dc3b"}}, "title": "Rapid point-of-care serology testing for sars-cov-2", "authors": [{"family": "Stackelberg", "given": "Otto", "initials": "O"}, {"family": "Esmaeilzadeh", "given": "Mouna", "initials": "M"}, {"family": "Olsen", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "journal article", "published": "2020-05-27", "journal": {"title": "L\u00e4kartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": "Increasing evidence indicates immunity against severe acute respiratory syndrome coronavirus 2 (sars-cov-2) after covid-19, but it remains unclear for how long the protection remains. Serology testing seems to have a higher sensitivity than molecular diagnostics from 8 days after onset of symtoms, and should be part of risk assessment and epidemiological studies of COVID-19. The performance of commercial serological point-of-care (POC) lateral flow tests are highly manufacturer-dependant. Low sensitivity increases the risk of false negative results and could result in unnecessary quarantine of test persons with developed antibodies. Low specificity increases the risk of false positive results and could lead to false assumptions of immunity. Carefully selected serological POC tests for sars-cov-2 can be used in large scale testing but should only be used by licensed medical staff able to understand their limitations and interpret the results.", "doi": null, "pmid": "32463475", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "20078"}], "notes": [], "created": "2020-11-11T07:18:07.394Z", "modified": "2021-01-17T08:19:34.625Z"}, {"entity": "publication", "iuid": "69a038d2c6724972a73cb9af9a52933a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/69a038d2c6724972a73cb9af9a52933a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/69a038d2c6724972a73cb9af9a52933a"}}, "title": "Could SARS-CoV-2-Induced Hyperinflammation Magnify the Severity of Coronavirus Disease (CoViD-19) Leading to Acute Respiratory Distress Syndrome?", "authors": [{"family": "Girija", "given": "A S Smiline", "initials": "ASS"}, {"family": "Shankar", "given": "Esaki M", "initials": "EM"}, {"family": "Larsson", "given": "Marie", "initials": "M"}], "type": "journal-article", "published": "2020-05-27", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "11", "issue": null, "pages": "1206", "issn-l": "1664-3224"}, "abstract": null, "doi": "10.3389/fimmu.2020.01206", "pmid": "32574269", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7267050"}], "notes": [], "created": "2020-12-08T16:20:21.680Z", "modified": "2021-12-06T13:19:34.348Z"}, {"entity": "publication", "iuid": "c1f61053726a446fa7eafc9b35b98a00", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c1f61053726a446fa7eafc9b35b98a00.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c1f61053726a446fa7eafc9b35b98a00"}}, "title": "Early Phylogenetic Diversification of SARS-CoV-2: Determination of Variants and the Effect on Epidemiology, Immunology, and Diagnostics", "authors": [{"family": "Kaden", "given": "Rene", "initials": "R", "orcid": "0000-0002-2111-9751", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2be6374ef0bf4ba39e5f5dbbb059747f.json"}}], "type": "journal-article", "published": "2020-05-26", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "9", "issue": "6", "pages": "1615", "issn-l": "2077-0383"}, "abstract": "The phylogenetic clustering of 95 SARS-CoV-2 sequences from the first 3 months of the pandemic reveals insights into the early evolution of the virus and gives first indications of how the variants are globally distributed. Variants might become a challenge in terms of diagnostics, immunology, and effectiveness of drugs. All available whole genome sequence data from the NCBI database (March 16, 2020) were phylogenetically analyzed, and gene prediction as well as analysis of selected variants were performed. Antigenic regions and the secondary protein structure were predicted for selected variants. While some clusters are presenting the same variant with 100% identical bases, other SARS-CoV-2 lineages show a beginning diversification and phylogenetic clustering due to base substitutions and deletions in the genomes. First molecular epidemiological investigations are possible with the results by adding metadata as travelling history to the presented data. The advantage of variants in source tracing can be a challenge in terms of virulence, immune response, and immunological memory. Variants of viruses often show differences in virulence or antigenicity. This must also be considered in decisions like herd immunity. Diagnostic methods might not work if the variations or deletions are in target regions for the detection of the pathogen. One base substitution was detected in a primer binding site.", "doi": "10.3390/jcm9061615", "pmid": "32466577", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "jcm9061615"}, {"db": "pmc", "key": "PMC7356205"}], "notes": [], "created": "2020-11-19T14:22:24.295Z", "modified": "2021-12-06T13:19:14.235Z"}, {"entity": "publication", "iuid": "135a6c58b8464dc2a03b65a276926648", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/135a6c58b8464dc2a03b65a276926648.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/135a6c58b8464dc2a03b65a276926648"}}, "title": "Environmental impact of the COVID-19 pandemic - a lesson for the future.", "authors": [{"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME", "orcid": "0000-0002-1056-4761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58d2f06f64154a2f9b5b22ffbb7518a3.json"}}, {"family": "Young", "given": "Sean G", "initials": "SG", "orcid": "0000-0002-0054-0627", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/47701de524284532ba5e23aac25c1c6e.json"}}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD", "orcid": "0000-0002-7075-1059", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a4c50079915c44d39c996741c6156bfa.json"}}], "type": "editorial", "published": "2020-05-25", "journal": {"title": "Infect Ecol Epidemiol", "issn": "2000-8686", "issn-l": "2000-8686", "volume": "10", "issue": "1", "pages": "1768023"}, "abstract": "The environment is an integral component of human and animal health. COVID-19 is a global health challenge in the twenty-first century. The emergence of SARS-CoV-2 in Wuhan, China in December 2019, and its spread to regional countries and nowadays affecting more than 210 countries worldwide represents the first pandemic in history to be caused by a coronavirus. The COVID-19 pandemic has huge impacts on most aspects of human activities, as well as on the economy and health care systems. Lock-downs, quarantines and border closures in the wake of the pandemic have led to reductions in air pollution through decreased travel and production. These positive environmental effects are likely mostly temporary, but may serve as an example that changes in our way of life can have prompt positive effects for the environment and demonstrate the usefulness of travel-reducing measures such as teleconferencing. Thus, acknowledging that COVID-19 is first and foremost a global disaster, the pandemic may inspire to future behavioral changes with positive environmental effects.", "doi": "10.1080/20008686.2020.1768023", "pmid": "32922688", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "1768023"}, {"db": "pmc", "key": "PMC7448928"}], "notes": [], "created": "2020-11-22T09:32:53.923Z", "modified": "2021-12-06T13:18:56.009Z"}, {"entity": "publication", "iuid": "085268aa10e74516b1448ef2d74d1975", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/085268aa10e74516b1448ef2d74d1975.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/085268aa10e74516b1448ef2d74d1975"}}, "title": "Clinical and daily respiratory care and clinical trials within the COVID-19 era.", "authors": [{"family": "Diamant", "given": "Zuzana", "initials": "Z", "orcid": "0000-0003-0133-0100", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09c10bc9b15d4e8e80bfd0b11766bb58.json"}}, {"family": "Backer", "given": "Vibeke", "initials": "V", "orcid": "0000-0002-7806-7219", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/559002d5b8384167b98a692e0a26a30f.json"}}, {"family": "Bjermer", "given": "Leif", "initials": "L", "orcid": "0000-0002-3441-8099", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/00285adfb31749e9a0c62eaa99b0b373.json"}}], "type": "editorial", "published": "2020-05-25", "journal": {"title": "Eur Clin Respir J", "issn": "2001-8525", "issn-l": null, "volume": "7", "issue": "1", "pages": "1766817"}, "abstract": "Editorial", "doi": "10.1080/20018525.2020.1766817", "pmid": "32922694", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "1766817"}, {"db": "pmc", "key": "PMC7448908"}], "notes": [], "created": "2020-12-03T15:48:16.477Z", "modified": "2021-12-06T13:18:38.752Z"}, {"entity": "publication", "iuid": "3f3785befa6c48f79fd5365680857182", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f3785befa6c48f79fd5365680857182.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f3785befa6c48f79fd5365680857182"}}, "title": "Gambling During the COVID-19 Crisis - A Cause for Concern.", "authors": [{"family": "H\u00e5kansson", "given": "Anders", "initials": "A"}, {"family": "Fern\u00e1ndez-Aranda", "given": "Fernando", "initials": "F"}, {"family": "Mench\u00f3n", "given": "Jose M", "initials": "JM"}, {"family": "Potenza", "given": "Marc N", "initials": "MN"}, {"family": "Jim\u00e9nez-Murcia", "given": "Susana", "initials": "S"}], "type": "journal article", "published": "2020-05-21", "journal": {"title": "J Addict Med", "issn": "1935-3227", "volume": "14", "issue": "4", "pages": "e10-e12", "issn-l": null}, "abstract": ": The COVID-19 pandemic has the potential to worsen mental health problems in the general population, including increasing engagement in addictive behaviors. Here, we describe observations suggesting that the current crisis and its sequelae may worsen problem gambling. The current pandemic may impact financial and psychological well-being due to social isolation during spatial distancing, and these stressors in conjunction with substantial changes in gambling markets (land-based, online) during the pandemic may significantly influence gambling behaviors. This situation calls for rapid research initiatives in this area and preventive and regulatory measures by multiple stakeholders.", "doi": "10.1097/ADM.0000000000000690", "pmid": "32433365", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7273946"}], "notes": [], "created": "2020-12-09T11:37:03.546Z", "modified": "2021-12-06T13:17:38.631Z"}, {"entity": "publication", "iuid": "9c189a14da4c4d81a9fdfe210ce73acc", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9c189a14da4c4d81a9fdfe210ce73acc.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9c189a14da4c4d81a9fdfe210ce73acc"}}, "title": "Chemical Functionalization of 2D Materials", "authors": [{"family": "Mart\u00edn", "given": "Nazario", "initials": "N"}, {"family": "Tagmatarchis", "given": "Nikos", "initials": "N", "orcid": "0000-0001-7590-4635", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/68a0b82ac2764eb1951d727f8ec53c51.json"}}, {"family": "Wang", "given": "Qing Hua", "initials": "QH", "orcid": "0000-0002-7982-7275", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8777f9f0f45646309baebeddf649856c.json"}}, {"family": "Zhang", "given": "Xiaoyan", "initials": "X", "orcid": "0000-0002-5469-8630", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09b21da8cac141c29584498d44511889.json"}}], "type": "journal-article", "published": "2020-05-20", "journal": {"title": "Chem. Eur. J.", "issn": "0947-6539", "volume": "26", "issue": "29", "pages": "6292-6295", "issn-l": null}, "abstract": "This Special Issue of Chemistry-A European Journal is dedicated to the Chemical Functionalization of 2D Materials, and features some great contributions from experts in the field of 2D materials. This issue was originally assembled to support the Symposium G \"Chemical Functionalization of 2D Materials\" at the European Materials Research Society (E-MRS) 2020 Spring Meeting, which was originally scheduled to be held in Strasbourg, France, from May 25th to 29th, 2020. Although the E-MRS 2020 Spring Meeting has been cancelled due to the COVID-19 outbreak, the publication of this Special Issue has proceeded and has become even more important as the contributors discuss diverse and timely research themes related to 2D materials. In this Editorial, a brief overview of the different types of 2D materials is given, together with the chemical functionalization schemes that can be applied to them to achieve new properties as well as enable improved performance in applications. Some of the articles featured in this Special Issue are also highlighted, with the hope that they will inspire readers and further advance the field.", "doi": "10.1002/chem.202001304", "pmid": "32432399", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-09T11:38:10.781Z", "modified": "2021-12-06T13:16:27.356Z"}, {"entity": "publication", "iuid": "0a042c1b6ea14982811ebbf1d8386f35", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0a042c1b6ea14982811ebbf1d8386f35.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0a042c1b6ea14982811ebbf1d8386f35"}}, "title": "The pandemic of social media panic travels faster than the COVID-19 outbreak", "authors": [{"family": "Depoux", "given": "Anneliese", "initials": "A"}, {"family": "Martin", "given": "Sam", "initials": "S"}, {"family": "Karafillakis", "given": "Emilie", "initials": "E"}, {"family": "Preet", "given": "Raman", "initials": "R"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Larson", "given": "Heidi", "initials": "H"}], "type": "journal-article", "published": "2020-05-18", "journal": {"title": "J Travel Med", "issn": "1708-8305", "volume": "27", "issue": "3", "issn-l": null}, "abstract": null, "doi": "10.1093/jtm/taaa031", "pmid": "32125413", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5775501"}, {"db": "pmc", "key": "PMC7107516"}], "notes": [], "created": "2020-12-08T06:51:36.786Z", "modified": "2021-12-06T13:15:04.146Z"}, {"entity": "publication", "iuid": "6b6f0a046e184dc19d670a98b5567b07", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6b6f0a046e184dc19d670a98b5567b07.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6b6f0a046e184dc19d670a98b5567b07"}}, "title": "High population densities catalyse the spread of COVID-19", "authors": [{"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}, {"family": "Sj\u00f6din", "given": "Henrik", "initials": "H"}], "type": "journal-article", "published": "2020-05-18", "journal": {"title": "J Travel Med", "issn": "1708-8305", "volume": "27", "issue": "3", "issn-l": null}, "abstract": null, "doi": "10.1093/jtm/taaa038", "pmid": "32227186", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5807719"}, {"db": "pmc", "key": "PMC7184409"}], "notes": [], "created": "2020-12-09T11:47:10.998Z", "modified": "2021-12-06T13:14:39.528Z"}, {"entity": "publication", "iuid": "3a86650407624b3db05844404767e6c6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3a86650407624b3db05844404767e6c6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3a86650407624b3db05844404767e6c6"}}, "title": "COVID-19 outbreak on the Diamond Princess cruise ship: estimating the epidemic potential and effectiveness of public health countermeasures", "authors": [{"family": "Rockl\u00f6v", "given": "J", "initials": "J"}, {"family": "Sj\u00f6din", "given": "H", "initials": "H"}, {"family": "Wilder-Smith", "given": "A", "initials": "A"}], "type": "journal-article", "published": "2020-05-18", "journal": {"title": "J Travel Med", "issn": "1708-8305", "issn-l": null, "volume": "27", "issue": "3", "pages": null}, "abstract": "Cruise ships carry a large number of people in confined spaces with relative homogeneous mixing. On 3 February, 2020, an outbreak of COVID-19 on cruise ship Diamond Princess was reported with 10 initial cases, following an index case on board around 21-25th January. By 4th February, public health measures such as removal and isolation of ill passengers and quarantine of non-ill passengers were implemented. By 20th February, 619 of 3700 passengers and crew (17%) were tested positive.\n\nWe estimated the basic reproduction number from the initial period of the outbreak using SEIR models. We calibrated the models with transient functions of countermeasures to incidence data. We additionally estimated a counterfactual scenario in absence of countermeasures, and established a model stratified by crew and guests to study the impact of differential contact rates among the groups. We also compared scenarios of an earlier versus later evacuation of the ship.\n\nThe basic reproduction rate was initially 4 times higher on-board compared to the ${R}_0$ in the epicentre in Wuhan, but the countermeasures lowered it substantially. Based on the modeled initial ${R}_0$ of 14.8, we estimated that without any interventions within the time period of 21 January to 19 February, 2920 out of the 3700 (79%) would have been infected. Isolation and quarantine therefore prevented 2307 cases, and lowered the ${R}_0$ to 1.78. We showed that an early evacuation of all passengers on 3 February would have been associated with 76 infected persons in their incubation time.\n\nThe cruise ship conditions clearly amplified an already highly transmissible disease. The public health measures prevented more than 2000 additional cases compared to no interventions. However, evacuating all passengers and crew early on in the outbreak would have prevented many more passengers and crew from infection.", "doi": "10.1093/jtm/taaa030", "pmid": "32109273", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "5766334"}, {"db": "pmc", "key": "PMC7107563"}], "notes": [], "created": "2020-12-08T06:57:54.802Z", "modified": "2021-12-06T13:14:19.397Z"}, {"entity": "publication", "iuid": "9fc6eb922a5a4c6db0605957f1abc618", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9fc6eb922a5a4c6db0605957f1abc618.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9fc6eb922a5a4c6db0605957f1abc618"}}, "title": "Esophageal oncologic surgery in SARS-CoV-2 (COVID-19) emergency", "authors": [{"family": "Barbieri", "given": "Lavinia", "initials": "L"}, {"family": "Talavera Urquijo", "given": "Eider", "initials": "E", "orcid": "0000-0002-4793-5378", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/db65329d4f1f487fa3afd522549e7430.json"}}, {"family": "Parise", "given": "Paolo", "initials": "P"}, {"family": "Nilsson", "given": "Magnus", "initials": "M"}, {"family": "Reynolds", "given": "John V", "initials": "JV"}, {"family": "Rosati", "given": "Riccardo", "initials": "R"}], "type": "journal-article", "published": "2020-05-15", "journal": {"title": "Dis Esophagus", "issn": "1442-2050", "volume": "33", "issue": "5", "pages": null, "issn-l": "1120-8694"}, "abstract": "Guidelines", "doi": "10.1093/dote/doaa028", "pmid": "32322892", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5823899"}, {"db": "pmc", "key": "PMC7188144"}], "notes": [], "created": "2020-11-23T11:45:36.075Z", "modified": "2021-12-06T13:13:34.720Z"}, {"entity": "publication", "iuid": "c9ed13bb0adf4357acdc4ce11d04ed45", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c9ed13bb0adf4357acdc4ce11d04ed45.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c9ed13bb0adf4357acdc4ce11d04ed45"}}, "title": "Deubiquitinating Enzymes in Coronaviruses and Possible Therapeutic Opportunities for COVID-19", "authors": [{"family": "Clemente", "given": "Valentino", "initials": "V"}, {"family": "D\u2019Arcy", "given": "Padraig", "initials": "P"}, {"family": "Bazzaro", "given": "Martina", "initials": "M"}], "type": "journal-article", "published": "2020-05-15", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "21", "issue": "10", "pages": "3492", "issn-l": null}, "abstract": "Following the outbreak of novel severe acute respiratory syndrome (SARS)-coronavirus (CoV)2, the majority of nations are struggling with countermeasures to fight infection, prevent spread and improve patient survival. Considering that the pandemic is a recent event, no large clinical trials have been possible and since coronavirus specific drug are not yet available, there is no strong consensus on how to treat the coronavirus disease 2019 (COVID-19) associated viral pneumonia. Coronaviruses code for an important multifunctional enzyme named papain-like protease (PLP), that has many roles in pathogenesis. First, PLP is one of the two viral cysteine proteases, along with 3-chymotripsin-like protease, that is responsible for the production of the replicase proteins required for viral replication. Second, its intrinsic deubiquitinating and deISGylating activities serve to antagonize the host's immune response that would otherwise hinder infection. Both deubiquitinating and deISGylating functions involve the removal of the small regulatory polypeptides, ubiquitin and ISG15, respectively, from target proteins. Ubiquitin modifications can regulate the innate immune response by affecting regulatory proteins, either by altering their stability via the ubiquitin proteasome pathway or by directly regulating their activity. ISG15 is a ubiquitin-like modifier with pleiotropic effects, typically expressed during the host cell immune response. PLP inhibitors have been evaluated during past coronavirus epidemics, and have showed promising results as an antiviral therapy in vitro. In this review, we recapitulate the roles of PLPs in coronavirus infections, report a list of PLP inhibitors and suggest possible therapeutic strategies for COVID-19 treatment, using both clinical and preclinical drugs.", "doi": "10.3390/ijms21103492", "pmid": "32429099", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "ijms21103492"}, {"db": "pmc", "key": "PMC7278987"}], "notes": [], "created": "2020-11-30T09:04:50.366Z", "modified": "2021-12-06T13:13:11.678Z"}, {"entity": "publication", "iuid": "13a9b64f789f4868a0c2bbb0b75fe84c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/13a9b64f789f4868a0c2bbb0b75fe84c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/13a9b64f789f4868a0c2bbb0b75fe84c"}}, "title": "COVID-19-Related Suicides in Bangladesh Due to Lockdown and Economic Factors: Case Study Evidence from Media Reports.", "authors": [{"family": "Bhuiyan", "given": "A K M Israfil", "initials": "AKMI"}, {"family": "Sakib", "given": "Najmuj", "initials": "N"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA"}], "type": "journal article", "published": "2020-05-15", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "volume": null, "issue": null, "pages": "1-6", "issn-l": null}, "abstract": null, "doi": "10.1007/s11469-020-00307-y", "pmid": "32427168", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "307"}, {"db": "pmc", "key": "PMC7228428"}], "notes": [], "created": "2020-12-09T11:40:51.584Z", "modified": "2021-12-06T13:12:52.761Z"}, {"entity": "publication", "iuid": "5669972f04844d0c8d2663e7733278b7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5669972f04844d0c8d2663e7733278b7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5669972f04844d0c8d2663e7733278b7"}}, "title": "Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2.", "authors": [{"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Kwon", "given": "Hyesoo", "initials": "H"}, {"family": "Prado", "given": "Patricia", "initials": "P"}, {"family": "Hagelkr\u00fcys", "given": "Astrid", "initials": "A"}, {"family": "Wimmer", "given": "Reiner A", "initials": "RA"}, {"family": "Stahl", "given": "Martin", "initials": "M"}, {"family": "Leopoldi", "given": "Alexandra", "initials": "A"}, {"family": "Garreta", "given": "Elena", "initials": "E"}, {"family": "Hurtado Del Pozo", "given": "Carmen", "initials": "C"}, {"family": "Prosper", "given": "Felipe", "initials": "F"}, {"family": "Romero", "given": "Juan Pablo", "initials": "JP"}, {"family": "Wirnsberger", "given": "Gerald", "initials": "G"}, {"family": "Zhang", "given": "Haibo", "initials": "H"}, {"family": "Slutsky", "given": "Arthur S", "initials": "AS"}, {"family": "Conder", "given": "Ryan", "initials": "R"}, {"family": "Montserrat", "given": "Nuria", "initials": "N"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}], "type": "journal article", "published": "2020-05-14", "journal": {"title": "Cell", "issn": "1097-4172", "issn-l": "0092-8674", "volume": "181", "issue": "4", "pages": "905-913.e7"}, "abstract": "We have previously provided the first genetic evidence that angiotensin converting enzyme 2 (ACE2) is the critical receptor for severe acute respiratory syndrome coronavirus (SARS-CoV), and ACE2 protects the lung from injury, providing a molecular explanation for the severe lung failure and death due to SARS-CoV infections. ACE2 has now also been identified as a key receptor for SARS-CoV-2 infections, and it has been proposed that inhibiting this interaction might be used in treating patients with COVID-19. However, it is not known whether human recombinant soluble ACE2 (hrsACE2) blocks growth of SARS-CoV-2. Here, we show that clinical grade hrsACE2 reduced SARS-CoV-2 recovery from Vero cells by a factor of 1,000-5,000. An equivalent mouse rsACE2 had no effect. We also show that SARS-CoV-2 can directly infect engineered human blood vessel organoids and human kidney organoids, which can be inhibited by hrsACE2. These data demonstrate that hrsACE2 can significantly block early stages of SARS-CoV-2 infections.", "doi": "10.1016/j.cell.2020.04.004", "pmid": "32333836", "labels": {"Type: Journal article": null, "Funder: VR": null, "Funder: H2020": null, "Category: Biochemistry": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "S0092-8674(20)30399-8"}, {"db": "pmc", "key": "PMC7181998"}], "notes": [], "created": "2020-12-09T14:57:55.780Z", "modified": "2021-12-06T13:12:24.868Z"}, {"entity": "publication", "iuid": "2ce4cebb6df144ffae6ee014ab7b79a6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ce4cebb6df144ffae6ee014ab7b79a6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ce4cebb6df144ffae6ee014ab7b79a6"}}, "title": "EAPCI Position Statement on Invasive Management of Acute Coronary Syndromes during the COVID-19 pandemic.", "authors": [{"family": "Chieffo", "given": "Alaide", "initials": "A"}, {"family": "Stefanini", "given": "Giulio G", "initials": "GG"}, {"family": "Price", "given": "Susanna", "initials": "S"}, {"family": "Barbato", "given": "Emanuele", "initials": "E"}, {"family": "Tarantini", "given": "Giuseppe", "initials": "G"}, {"family": "Karam", "given": "Nicole", "initials": "N"}, {"family": "Moreno", "given": "Raul", "initials": "R"}, {"family": "Buchanan", "given": "Gill Louise", "initials": "GL"}, {"family": "Gilard", "given": "Martine", "initials": "M"}, {"family": "Halvorsen", "given": "Sigrun", "initials": "S"}, {"family": "Huber", "given": "Kurt", "initials": "K"}, {"family": "James", "given": "Stefan", "initials": "S"}, {"family": "Neumann", "given": "Franz-Josef", "initials": "FJ"}, {"family": "M\u00f6llmann", "given": "Helge", "initials": "H"}, {"family": "Roffi", "given": "Marco", "initials": "M"}, {"family": "Tavazzi", "given": "Guido", "initials": "G"}, {"family": "Mauri Ferr\u00e9", "given": "Josepa", "initials": "J"}, {"family": "Windecker", "given": "Stephan", "initials": "S"}, {"family": "Dudek", "given": "Dariusz", "initials": "D"}, {"family": "Baumbach", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2020-05-14", "journal": {"title": "Eur Heart J", "issn": "1522-9645", "volume": "41", "issue": "19", "pages": "1839-1851", "issn-l": "0195-668X"}, "abstract": "The coronavirus disease 2019 (COVID-19) pandemic poses an unprecedented challenge to healthcare worldwide. The infection can be life threatening and require intensive care treatment. The transmission of the disease poses a risk to both patients and healthcare workers. The number of patients requiring hospital admission and intensive care may overwhelm health systems and negatively affect standard care for patients presenting with conditions needing emergency interventions. This position statements aims to assist cardiologists in the invasive management of acute coronary syndrome (ACS) patients in the context of the COVID-19 pandemic. To that end, we assembled a panel of interventional cardiologists and acute cardiac care specialists appointed by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) and from the Acute Cardiovascular Care Association (ACVC) and included the experience from the first and worst affected areas in Europe. Modified diagnostic and treatment algorithms are proposed to adapt evidence-based protocols for this unprecedented challenge. Various clinical scenarios, as well as management algorithms for patients with a diagnosed or suspected COVID-19 infection, presenting with ST- and non-ST-segment elevation ACS are described. In addition, we address the need for re-organization of ACS networks, with redistribution of hub and spoke hospitals, as well as for in-hospital reorganization of emergency rooms and cardiac units, with examples coming from multiple European countries. Furthermore, we provide a guidance to reorganization of catheterization laboratories and, importantly, measures for protection of healthcare providers involved with invasive procedures.", "doi": "10.1093/eurheartj/ehaa381", "pmid": "32405641", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5836093"}, {"db": "pmc", "key": "PMC7239193"}], "notes": [], "created": "2020-12-10T08:49:39.425Z", "modified": "2021-12-06T13:12:03.006Z"}, {"entity": "publication", "iuid": "bad2b8ef26c14d8ea4275d7fdce85d0b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/bad2b8ef26c14d8ea4275d7fdce85d0b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/bad2b8ef26c14d8ea4275d7fdce85d0b"}}, "title": "Recommendations for Physical Inactivity and Sedentary Behavior During the Coronavirus Disease (COVID-19) Pandemic.", "authors": [{"family": "Ricci", "given": "Fabrizio", "initials": "F"}, {"family": "Izzicupo", "given": "Pascal", "initials": "P"}, {"family": "Moscucci", "given": "Federica", "initials": "F"}, {"family": "Sciomer", "given": "Susanna", "initials": "S"}, {"family": "Maffei", "given": "Silvia", "initials": "S"}, {"family": "Di Baldassarre", "given": "Angela", "initials": "A"}, {"family": "Mattioli", "given": "Anna Vittoria", "initials": "AV"}, {"family": "Gallina", "given": "Sabina", "initials": "S"}], "type": "journal article", "published": "2020-05-12", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "199", "issn-l": "2296-2565"}, "abstract": null, "doi": "10.3389/fpubh.2020.00199", "pmid": "32574294", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7235318"}], "notes": [], "created": "2020-12-08T16:18:42.625Z", "modified": "2021-12-06T13:11:44.902Z"}, {"entity": "publication", "iuid": "42a9ec324c29452b9841ab1130a695bd", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/42a9ec324c29452b9841ab1130a695bd.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/42a9ec324c29452b9841ab1130a695bd"}}, "title": "Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 \u2013 implications for microvascular inflammation and hypercoagulopathy in COVID-19", "authors": [{"family": "He", "given": "Liqun", "initials": "L"}, {"family": "M\u00e4e", "given": "Maarja Andaloussi", "initials": "MA"}, {"family": "Muhl", "given": "Lars", "initials": "L"}, {"family": "Sun", "given": "Ying", "initials": "Y"}, {"family": "Pietil\u00e4", "given": "Riikka", "initials": "R"}, {"family": "Nahar", "given": "Khayrun", "initials": "K"}, {"family": "Li\u00e9banas", "given": "Elisa V\u00e1zquez", "initials": "EV"}, {"family": "Fagerlund", "given": "Malin Jonsson", "initials": "MJ"}, {"family": "Oldner", "given": "Anders", "initials": "A"}, {"family": "Liu", "given": "Jianping", "initials": "J"}, {"family": "Genov\u00e9", "given": "Guillem", "initials": "G"}, {"family": "Zhang", "given": "Lei", "initials": "L"}, {"family": "Xie", "given": "Yuan", "initials": "Y"}, {"family": "Leptidis", "given": "Stefanos", "initials": "S"}, {"family": "Mocci", "given": "Giuseppe", "initials": "G"}, {"family": "Stritt", "given": "Simon", "initials": "S"}, {"family": "Osman", "given": "Ahmed", "initials": "A"}, {"family": "Anisimov", "given": "Andrey", "initials": "A"}, {"family": "Hemanthakumar", "given": "Karthik Amudhala", "initials": "KA"}, {"family": "R\u00e4s\u00e4nen", "given": "Markus", "initials": "M"}, {"family": "Mirabeau", "given": "Olivier", "initials": "O"}, {"family": "Hansson", "given": "Emil", "initials": "E"}, {"family": "Bj\u00f6rkegren", "given": "Johan", "initials": "J"}, {"family": "Vanlandewijck", "given": "Michael", "initials": "M"}, {"family": "Blomgren", "given": "Klas", "initials": "K"}, {"family": "M\u00e4kinen", "given": "Taija", "initials": "T"}, {"family": "Peng", "given": "Xiao Rong", "initials": "XR"}, {"family": "Arnold", "given": "Thomas D", "initials": "TD"}, {"family": "Alitalo", "given": "Kari", "initials": "K"}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Lendahl", "given": "Urban", "initials": "U"}, {"family": "Betsholtz", "given": "Christer", "initials": "C"}], "type": "posted-content", "published": "2020-05-12", "journal": {"title": "bioRxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.05.11.088500", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-01-20T06:40:52.233Z", "modified": "2021-12-06T13:11:25.970Z"}, {"entity": "publication", "iuid": "614cd9f9b80d48699960dc262af705ff", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/614cd9f9b80d48699960dc262af705ff.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/614cd9f9b80d48699960dc262af705ff"}}, "title": "Coronavirus Disease 2019 Return to Work Guidance and Recommendations for Vestibular Clinicians", "authors": [{"family": "Rizk", "given": "Habib G", "initials": "HG"}, {"family": "Strange", "given": "Christine", "initials": "C"}, {"family": "Atallah", "given": "Stephanie", "initials": "S"}, {"family": "Massingale", "given": "Shelly", "initials": "S"}, {"family": "Clendaniel", "given": "Richard", "initials": "R"}], "type": "journal-article", "published": "2020-05-12", "journal": {"title": "Ear Hear", "issn": "1538-4667", "volume": "41", "issue": "4", "pages": "693-696", "issn-l": null}, "abstract": "As states begin issuing progressive deconfinement guidelines, hospitals and institutions are starting to reopen for elective procedures and consultations. Vestibular clinicians are opening their practices to evaluate, test, or treat patients with dizziness and balance problems. The following document, requested by the American Balance Society, collates the current information about the virus, including transmission from asymptomatic carriers, decontamination, and other safety protocols, and provides a return to work guidance for clinicians caring for this population of patients, promoting provider, patient, and staff safety.", "doi": "10.1097/aud.0000000000000903", "pmid": "32427744", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-09T11:39:58.568Z", "modified": "2021-12-06T13:16:51.259Z"}, {"entity": "publication", "iuid": "626155cf829443a982103aceb07bea87", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/626155cf829443a982103aceb07bea87.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/626155cf829443a982103aceb07bea87"}}, "title": "Psychometric Validation of the Bangla Fear of COVID-19 Scale: Confirmatory Factor Analysis and Rasch Analysis", "authors": [{"family": "Sakib", "given": "Najmuj", "initials": "N"}, {"family": "Bhuiyan", "given": "A K M Israfil", "initials": "AKMI"}, {"family": "Hossain", "given": "Sahadat", "initials": "S"}, {"family": "Al Mamun", "given": "Firoj", "initials": "F"}, {"family": "Hosen", "given": "Ismail", "initials": "I"}, {"family": "Abdullah", "given": "Abu Hasnat", "initials": "AH"}, {"family": "Sarker", "given": "Md Abedin", "initials": "MA"}, {"family": "Mohiuddin", "given": "Mohammad Sarif", "initials": "MS"}, {"family": "Rayhan", "given": "Istihak", "initials": "I"}, {"family": "Hossain", "given": "Moazzem", "initials": "M"}, {"family": "Sikder", "given": "Md Tajuddin", "initials": "MT"}, {"family": "Gozal", "given": "David", "initials": "D"}, {"family": "Muhit", "given": "Mohammad", "initials": "M"}, {"family": "Islam", "given": "S M Shariful", "initials": "SMS"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD", "orcid": "0000-0001-8880-6524", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fb3f9ead17664345acaaf03a7b4d9c33.json"}}, {"family": "Pakpour", "given": "Amir H", "initials": "AH", "orcid": "0000-0002-8798-5345", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/040d59a54588468a94131808dfe1b256.json"}}, {"family": "Mamun", "given": "Mohammed A", "initials": "MA", "orcid": "0000-0002-1728-8966", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/f6e65a5a97154d159a63cc2ce3f1b7a8.json"}}], "type": "journal-article", "published": "2020-05-11", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "issn-l": null, "volume": null, "issue": null, "pages": "1-12"}, "abstract": "The recently developed Fear of COVID-19 Scale (FCV-19S) is a seven-item uni-dimensional scale that assesses the severity of fears of COVID-19. Given the rapid increase of COVID-19 cases in Bangladesh, we aimed to translate and validate the FCV-19S in Bangla. The forward-backward translation method was used to translate the English version of the questionnaire into Bangla. The reliability and validity properties of the Bangla FCV-19S were rigorously psychometrically evaluated (utilizing both confirmatory factor analysis and Rasch analysis) in relation to socio-demographic variables, national lockdown variables, and response to the Bangla Health Patient Questionnaire. The sample comprised 8550 Bangladeshi participants. The Cronbach \u03b1 value for the Bangla FCV-19S was 0.871 indicating very good internal reliability. The results of the confirmatory factor analysis showed that the uni-dimensional factor structure of the FCV-19S fitted well with the data. The FCV-19S was significantly correlated with the nine-item Bangla Patient Health Questionnaire (PHQ-90) (r = 0.406, p < 0.001). FCV-19S scores were significantly associated with higher worries concerning lockdown. Measurement invariance of the FCV-19S showed no differences with respect to age or gender. The Bangla version of FCV-19S is a valid and reliable tool with robust psychometric properties which will be useful for researchers carrying out studies among the Bangla speaking population in assessing the psychological impact of fear from COVID-19 infection during this pandemic.", "doi": "10.1007/s11469-020-00289-x", "pmid": "32395096", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pii", "key": "289"}, {"db": "pmc", "key": "PMC7213549"}], "notes": [], "created": "2020-12-10T08:40:21.782Z", "modified": "2021-12-06T13:11:04.811Z"}, {"entity": "publication", "iuid": "884f876e112344c6a4d186eb368a32be", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/884f876e112344c6a4d186eb368a32be.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/884f876e112344c6a4d186eb368a32be"}}, "title": "Interventions for treatment of COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING Project).", "authors": [{"family": "Juul", "given": "Sophie", "initials": "S", "orcid": "0000-0002-6171-2904", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/76a1c669d07f4d559ae43063bb008b68.json"}}, {"family": "Nielsen", "given": "Niklas", "initials": "N"}, {"family": "Bentzer", "given": "Peter", "initials": "P"}, {"family": "Veroniki", "given": "Areti Angeliki", "initials": "AA"}, {"family": "Thabane", "given": "Lehana", "initials": "L"}, {"family": "Linder", "given": "Adam", "initials": "A"}, {"family": "Klingenberg", "given": "Sarah", "initials": "S"}, {"family": "Gluud", "given": "Christian", "initials": "C"}, {"family": "Jakobsen", "given": "Janus Christian", "initials": "JC"}], "type": "journal article", "published": "2020-05-09", "journal": {"title": "Syst Rev", "issn": "2046-4053", "volume": "9", "issue": "1", "pages": "108", "issn-l": null}, "abstract": "COVID-19 is a rapidly spreading virus infection that has quickly caused extensive burden to individual, families, countries, and the globe. No intervention has yet been proven effective for the treatment of COVID-19. Some randomized clinical trials assessing the effects of different drugs have been published, and more are currently underway. There is an urgent need for a living, dynamic systematic review that continuously evaluates the beneficial and harmful effects of all available interventions for COVID-19.\n\nWe will conduct a living systematic review based on searches of major medical databases (e.g., MEDLINE, EMBASE, CENTRAL) and clinical trial registries from their inception onwards to identify relevant randomized clinical trials. We will update the literature search once a week to continuously assess if new evidence is available. Two review authors will independently extract data and perform risk of bias assessment. We will include randomized clinical trials comparing any intervention for the treatment of COVID-19 (e.g., pharmacological interventions, fluid therapy, invasive or noninvasive ventilation, or similar interventions) with any comparator (e.g., an \"active\" comparator, standard care, placebo, no intervention, or \"active placebo\") for participants in all age groups with a diagnosis of COVID-19. Primary outcomes will be all-cause mortality and serious adverse events. Secondary outcomes will be admission to intensive care, mechanical ventilation, renal replacement therapy, quality of life, and non-serious adverse events. The living systematic review will include aggregate data meta-analyses, Trial Sequential Analyses, network meta-analysis, and individual patient data meta-analyses. Risk of bias will be assessed with domains, an eight-step procedure will be used to assess if the thresholds for clinical significance are crossed, and the certainty of the evidence will be assessed by Grading of Recommendations, Assessment, Development and Evaluations (GRADE).\n\nCOVID-19 has become a pandemic with substantial mortality. A living systematic review evaluating the beneficial and harmful effects of pharmacological and other interventions is urgently needed. This review will continuously inform best practice in treatment and clinical research of this highly prevalent disease.\n\nPROSPERO CRD42020178787.", "doi": "10.1186/s13643-020-01371-0", "pmid": "32386514", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s13643-020-01371-0"}, {"db": "pmc", "key": "PMC7210799"}], "notes": [], "created": "2020-11-30T09:08:00.686Z", "modified": "2021-12-06T13:10:13.292Z"}, {"entity": "publication", "iuid": "0cafcc70a7c24a7ab4559b6faf5bba13", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0cafcc70a7c24a7ab4559b6faf5bba13.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0cafcc70a7c24a7ab4559b6faf5bba13"}}, "title": "Development and Potential Usefulness of the COVID-19 Ag Respi-Strip Diagnostic Assay in a Pandemic Context", "authors": [{"family": "Mertens", "given": "Pascal", "initials": "P"}, {"family": "De Vos", "given": "Nathalie", "initials": "N"}, {"family": "Martiny", "given": "Delphine", "initials": "D"}, {"family": "Jassoy", "given": "Christian", "initials": "C"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Cuypers", "given": "Lize", "initials": "L"}, {"family": "Van den Wijngaert", "given": "Sigi", "initials": "S"}, {"family": "Monteil", "given": "Vanessa", "initials": "V"}, {"family": "Melin", "given": "Pierrette", "initials": "P"}, {"family": "Stoffels", "given": "Karolien", "initials": "K"}, {"family": "Yin", "given": "Nicolas", "initials": "N"}, {"family": "Mileto", "given": "Davide", "initials": "D"}, {"family": "Delaunoy", "given": "Sabrina", "initials": "S"}, {"family": "Magein", "given": "Henri", "initials": "H"}, {"family": "Lagrou", "given": "Katrien", "initials": "K"}, {"family": "Bouzet", "given": "Justine", "initials": "J"}, {"family": "Serrano", "given": "Gabriela", "initials": "G"}, {"family": "Wautier", "given": "Magali", "initials": "M"}, {"family": "Leclipteux", "given": "Thierry", "initials": "T"}, {"family": "Van Ranst", "given": "Marc", "initials": "M"}, {"family": "Vandenberg", "given": "Olivier", "initials": "O"}, {"family": null, "given": "", "initials": ""}], "type": "journal-article", "published": "2020-05-08", "journal": {"title": "Front Med (Lausanne)", "issn": "2296-858X", "volume": "7", "issue": null, "pages": "225", "issn-l": null}, "abstract": "Introduction: COVID-19 Ag Respi-Strip, an immunochromatographic (ICT) assay for the rapid detection of SARS-CoV-2 antigen on nasopharyngeal specimen, has been developed to identify positive COVID-19 patients allowing prompt clinical and quarantine decisions. In this original research article, we describe the conception, the analytical and clinical performances as well as the risk management of implementing the COVID-19 Ag Respi-Strip in a diagnostic decision algorithm. Materials and Methods: Development of the COVID-19 Ag Respi-Strip resulted in a ready-to-use ICT assay based on a membrane technology with colloidal gold nanoparticles using monoclonal antibodies directed against the SARS-CoV and SARS-CoV-2 highly conserved nucleoprotein antigen. Four hundred observations were recorded for the analytical performance study and thirty tests were analyzed for the cross-reactivity study. The clinical performance study was performed in a retrospective multi-centric evaluation on aliquots of 328 nasopharyngeal samples. COVID-19 Ag Respi-Strip results were compared with qRT-PCR as golden standard for COVID-19 diagnostics. Results: In the analytical performance study, the reproducibility showed a between-observer disagreement of 1.7%, a robustness of 98%, an overall satisfying user friendliness and no cross-reactivity with other virus-infected nasopharyngeal samples. In the clinical performance study performed in three different clinical laboratories during the ascendant phase of the epidemiological curve, we found an overall sensitivity and specificity of 57.6 and 99.5%, respectively with an accuracy of 82.6%. The cut-off of the ICT was found at CT <22. User-friendliness analysis and risk management assessment through Ishikawa diagram demonstrate that COVID-19 Ag Respi-Strip may be implemented in clinical laboratories according to biosafety recommendations. Conclusion: The COVID-19 Ag Respi-Strip represents a promising rapid SARS-CoV-2 antigen assay for the first-line diagnosis of COVID-19 in 15 min at the peak of the pandemic. Its role in the proposed diagnostic algorithm is complementary to the currently-used molecular techniques.", "doi": "10.3389/fmed.2020.00225", "pmid": "32574326", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7227790"}], "notes": [], "created": "2020-12-08T16:17:00.223Z", "modified": "2021-12-06T13:09:54.471Z"}, {"entity": "publication", "iuid": "908ed23706424854b3d884aeef134258", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/908ed23706424854b3d884aeef134258.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/908ed23706424854b3d884aeef134258"}}, "title": "The Battle Against COVID-19 in Jordan: An Early Overview of the Jordanian Experience", "authors": [{"family": "Al-Tammemi", "given": "Ala'a B", "initials": "AB"}], "type": "journal-article", "published": "2020-05-07", "journal": {"title": "Front Public Health", "issn": "2296-2565", "volume": "8", "issue": null, "pages": "188", "issn-l": "2296-2565"}, "abstract": "Since the initial spark of the COVID-19 outbreak in December 2019, which was later declared by the World Health Organization (WHO) to be a global pandemic, all affected countries are implementing various preventive and control measures to mitigate the spread of the disease. The newly emerging virus brings with it uncertainty-not only regarding its behavior and transmission dynamics but also regarding the current lack of approved antiviral therapy or vaccines-and this represents a major challenge for decision makers at various levels and sectors. This article aims to provide an early overview of the COVID-19 battle within the Jordanian context, including general reflections and conclusions on the value of collaborative efforts in crises management.", "doi": "10.3389/fpubh.2020.00188", "pmid": "32574291", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pmc", "key": "PMC7220996"}], "notes": [], "created": "2020-12-08T16:19:43.270Z", "modified": "2021-12-06T13:09:24.624Z"}, {"entity": "publication", "iuid": "880034e9b5a34bad9a810847f9895f9a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/880034e9b5a34bad9a810847f9895f9a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/880034e9b5a34bad9a810847f9895f9a"}}, "title": "Management of COVID-19-Positive Pediatric Patients Undergoing Minimally Invasive Surgical Procedures: Systematic Review and Recommendations of the Board of European Society of Pediatric Endoscopic Surgeons", "authors": [{"family": "Pini Prato", "given": "Alessio", "initials": "A"}, {"family": "Conforti", "given": "Andrea", "initials": "A"}, {"family": "Almstrom", "given": "Markus", "initials": "M"}, {"family": "Van Gemert", "given": "Wim", "initials": "W"}, {"family": "Scuderi", "given": "Maria G", "initials": "MG"}, {"family": "Khen-Dunlop", "given": "Naziha", "initials": "N"}, {"family": "Draghici", "given": "Isabela", "initials": "I"}, {"family": "Mendoza-Sagaon", "given": "Mario", "initials": "M"}, {"family": "Gin\u00e9 Prades", "given": "Carlos", "initials": "C"}, {"family": "Chiarenza", "given": "Fabio", "initials": "F"}, {"family": "Steyaert", "given": "Henri", "initials": "H"}], "type": "journal-article", "published": "2020-05-07", "journal": {"title": "Front Pediatr", "issn": "2296-2360", "volume": "8", "issue": null, "pages": "259", "issn-l": "2296-2360"}, "abstract": "Introduction: Hospital response to the COVID-19 outbreak has involved the cancellation of elective, deferrable surgeries throughout Europe in order to ensure capacity for emergent surgery and a selection of elective but non-deferrable surgeries. The purpose of this document is to propose technical strategies to assist the pediatric surgeons to minimize the potential aerosolization of viral particles in COVID-19 patients undergoing urgent or emergent surgical treatment using laparoscopic approaches, based on the currently available literature. The situation and recommendations are subject to change with emerging information. Materials and Methods: The Scientific Committee and the Board of the European Society of Pediatric Endoscopic Surgeons gathered together in order to address the issue of minimally invasive surgery during this COVID-19 pandemic. A systematic search through PubMed, Embase, and World Wide Web of the terms \"COVID-19,\" \"Coronavirus,\" and \"SARS-CoV-2\" matched with \"pneumoperitoneum,\" \"laparoscopy,\" \"thoracoscopy,\" \"retroperitoneoscopy,\" and \"surgery\" was performed. Non-English language papers were excluded. A PRISMA report was performed. Criticalities were identified and a consensus was achieved over a number of key aspects. Results: We identified 121 documents. A total of 11 full-text documents were assessed to address all concerns related to the adoption of minimally invasive surgery. All aspect of pediatric minimally invasive surgery, including elective surgery, urgent surgery, laparoscopy, thoracoscopy, retroperitoneoscopy, and pneumoperitoneum creation and maintainance were extensively addressed through systematic review. A consensus regarding urgent laparoscopic procedures, setting and operation techniques was obtained within the Committee and the Board. Conclusions: The ESPES proposes the following recommendations in case minimally invasive surgery is needed in a COVID-19 positive pediatric patients: (1) consider conservative treatment whenever safely possible, (2) dedicate a theater, columns and reusable laparoscopic instrumentation to COVID-19 pediatric patients, (3) prefer disposable instrumentation and cables, (4) use low CO2 insufflation pressures, (5) use low power electrocautery, (6) prefer closed-systems CO2 insufflation and desufflation systems, and (7) avoid leaks through ports. These recommendations are subject to change with emerging information and might be amended in the near future.", "doi": "10.3389/fped.2020.00259", "pmid": "32550670", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7232605"}], "notes": [], "created": "2020-11-26T12:19:59.137Z", "modified": "2021-12-06T13:08:58.197Z"}, {"entity": "publication", "iuid": "86df86b0add04971b430d355b695172f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/86df86b0add04971b430d355b695172f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/86df86b0add04971b430d355b695172f"}}, "title": "Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?", "authors": [{"family": "Andersson", "given": "Ulf", "initials": "U", "orcid": "0000-0003-0316-3860", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ee9bbcb5111f446e99ff8b68c4027f5c.json"}}, {"family": "Ottestad", "given": "William", "initials": "W"}, {"family": "Tracey", "given": "Kevin J", "initials": "KJ"}], "type": "journal article", "published": "2020-05-07", "journal": {"title": "Mol Med", "issn": "1528-3658", "volume": "26", "issue": "1", "pages": "42", "issn-l": "1076-1551"}, "abstract": "The 2019 novel coronavirus disease (COVID-19) causes for unresolved reasons acute respiratory distress syndrome in vulnerable individuals. There is a need to identify key pathogenic molecules in COVID-19-associated inflammation attainable to target with existing therapeutic compounds. The endogenous damage-associated molecular pattern (DAMP) molecule HMGB1 initiates inflammation via two separate pathways. Disulfide-HMGB1 triggers TLR4 receptors generating pro-inflammatory cytokine release. Extracellular HMGB1, released from dying cells or secreted by activated innate immunity cells, forms complexes with extracellular DNA, RNA and other DAMP or pathogen-associated molecular (DAMP) molecules released after lytic cell death. These complexes are endocytosed via RAGE, constitutively expressed at high levels in the lungs only, and transported to the endolysosomal system, which is disrupted by HMGB1 at high concentrations. Danger molecules thus get access to cytosolic proinflammatory receptors instigating inflammasome activation. It is conceivable that extracellular SARS-CoV-2 RNA may reach the cellular cytosol via HMGB1-assisted transfer combined with lysosome leakage. Extracellular HMGB1 generally exists in vivo bound to other molecules, including PAMPs and DAMPs. It is plausible that these complexes are specifically removed in the lungs revealed by a 40% reduction of HMGB1 plasma levels in arterial versus venous blood. Abundant pulmonary RAGE expression enables endocytosis of danger molecules to be destroyed in the lysosomes at physiological HMGB1 levels, but causing detrimental inflammasome activation at high levels. Stress induces apoptosis in pulmonary endothelial cells from females but necrosis in cells from males.\n\nBased on these observations we propose extracellular HMGB1 to be considered as a therapeutic target for COVID-19.", "doi": "10.1186/s10020-020-00172-4", "pmid": "32380958", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1186/s10020-020-00172-4"}, {"db": "pmc", "key": "PMC7203545"}], "notes": [], "created": "2020-11-25T07:30:42.009Z", "modified": "2021-12-06T13:08:39.901Z"}, {"entity": "publication", "iuid": "8f6f511b573945a1be8bb0f50b2f68ad", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8f6f511b573945a1be8bb0f50b2f68ad.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8f6f511b573945a1be8bb0f50b2f68ad"}}, "title": "COVID-19: a challenge for oncology services.", "authors": [{"family": "Routy", "given": "Bertrand", "initials": "B"}, {"family": "Derosa", "given": "Lisa", "initials": "L"}, {"family": "Zitvogel", "given": "Laurence", "initials": "L", "orcid": "0000-0003-1596-0998", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/7b10947c1a2b4884b3f502625a28c5e0.json"}}, {"family": "Kroemer", "given": "Guido", "initials": "G", "orcid": "0000-0002-9334-4405", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/3d17de2122d0429eaa48a733bf2ad28e.json"}}], "type": "editorial", "published": "2020-05-05", "journal": {"title": "Oncoimmunology", "issn": "2162-4011", "volume": "9", "issue": "1", "pages": "1760686", "issn-l": null}, "abstract": null, "doi": "10.1080/2162402X.2020.1760686", "pmid": "32923119", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "1760686"}, {"db": "pmc", "key": "PMC7458620"}], "notes": [], "created": "2020-12-03T15:47:32.730Z", "modified": "2021-12-06T13:07:47.749Z"}, {"entity": "publication", "iuid": "01fac03dcd13402b921d766ed13344f4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/01fac03dcd13402b921d766ed13344f4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/01fac03dcd13402b921d766ed13344f4"}}, "title": "Digesting the crisis: autophagy and coronaviruses.", "authors": [{"family": "Carmona-Gutierrez", "given": "Didac", "initials": "D"}, {"family": "Bauer", "given": "Maria A", "initials": "MA"}, {"family": "Zimmermann", "given": "Andreas", "initials": "A"}, {"family": "Kainz", "given": "Katharina", "initials": "K"}, {"family": "Hofer", "given": "Sebastian J", "initials": "SJ"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}, {"family": "Madeo", "given": "Frank", "initials": "F"}], "type": "journal article", "published": "2020-05-04", "journal": {"title": "Microb Cell", "issn": "2311-2638", "volume": "7", "issue": "5", "pages": "119-128", "issn-l": "2311-2638"}, "abstract": "Autophagy is a catabolic pathway with multifaceted roles in cellular homeostasis. This process is also involved in the antiviral response at multiple levels, including the direct elimination of intruding viruses (virophagy), the presentation of viral antigens, the fitness of immune cells, and the inhibition of excessive inflammatory reactions. In line with its central role in immunity, viruses have evolved mechanisms to interfere with or to evade the autophagic process, and in some cases, even to harness autophagy or constituents of the autophagic machinery for their replication. Given the devastating consequences of the current COVID-19 pandemic, the question arises whether manipulating autophagy might be an expedient approach to fight the novel coronavirus SARS-CoV-2. In this piece, we provide a short overview of the evidence linking autophagy to coronaviruses and discuss whether such links may provide actionable targets for therapeutic interventions.", "doi": "10.15698/mic2020.05.715", "pmid": "32391393", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "MIC0270E122"}, {"db": "pmc", "key": "PMC7199282"}], "notes": [], "created": "2020-11-25T07:58:17.099Z", "modified": "2021-12-06T13:06:40.272Z"}, {"entity": "publication", "iuid": "b405175e46c046df86d6925d657f3ed8", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b405175e46c046df86d6925d657f3ed8.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b405175e46c046df86d6925d657f3ed8"}}, "title": "A united statement of the global chiropractic research community against the pseudoscientific claim that chiropractic care boosts immunity.", "authors": [{"family": "C\u00f4t\u00e9", "given": "Pierre", "initials": "P"}, {"family": "Bussi\u00e8res", "given": "Andr\u00e9", "initials": "A"}, {"family": "Cassidy", "given": "J David", "initials": "JD"}, {"family": "Hartvigsen", "given": "Jan", "initials": "J"}, {"family": "Kawchuk", "given": "Greg N", "initials": "GN"}, {"family": "Leboeuf-Yde", "given": "Charlotte", "initials": "C"}, {"family": "Mior", "given": "Silvano", "initials": "S"}, {"family": "Schneider", "given": "Michael", "initials": "M"}, {"family": "140 signatories# call for an end to pseudoscientific claims on the effect of chiropractic care on immune function", "given": "", "initials": ""}], "type": "journal article", "published": "2020-05-04", "journal": {"title": "Chiropr Man Therap", "issn": "2045-709X", "volume": "28", "issue": "1", "pages": "21", "issn-l": "2045-709X"}, "abstract": "In the midst of the coronavirus pandemic, the International Chiropractors Association (ICA) posted reports claiming that chiropractic care can impact the immune system. These claims clash with recommendations from the World Health Organization and World Federation of Chiropractic. We discuss the scientific validity of the claims made in these ICA reports.\n\nWe reviewed the two reports posted by the ICA on their website on March 20 and March 28, 2020. We explored the method used to develop the claim that chiropractic adjustments impact the immune system and discuss the scientific merit of that claim. We provide a response to the ICA reports and explain why this claim lacks scientific credibility and is dangerous to the public. More than 150 researchers from 11 countries reviewed and endorsed our response.\n\nIn their reports, the ICA provided no valid clinical scientific evidence that chiropractic care can impact the immune system. We call on regulatory authorities and professional leaders to take robust political and regulatory action against those claiming that chiropractic adjustments have a clinical impact on the immune system.", "doi": "10.1186/s12998-020-00312-x", "pmid": "32366319", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "10.1186/s12998-020-00312-x"}, {"db": "pmc", "key": "PMC7197358"}], "notes": [], "created": "2020-11-25T07:24:09.543Z", "modified": "2021-12-06T13:06:22.682Z"}, {"entity": "publication", "iuid": "5325440967464cc29a380ee219699347", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5325440967464cc29a380ee219699347.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5325440967464cc29a380ee219699347"}}, "title": "Preventing spread of SARS-CoV-2 and preparing for the COVID-19 outbreak in the surgical department: perspectives from two Scandinavian countries", "authors": [{"family": "Lindeman", "given": "Robbert Jan", "initials": "RJ"}, {"family": "Sund", "given": "Malin", "initials": "M"}, {"family": "L\u00f6fgren", "given": "Jenny", "initials": "J"}, {"family": "Basso", "given": "Trude", "initials": "T"}, {"family": "S\u00f8reide", "given": "Kjetil", "initials": "K", "orcid": "0000-0001-7594-4354", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d9c5655fc6aa437d91ed5cc2b4791543.json"}}], "type": "journal-article", "published": "2020-05-01", "journal": {"title": "J Surg Case Rep", "issn": "2042-8812", "issn-l": "2042-8812", "volume": "2020", "issue": "5", "pages": "rjaa131"}, "abstract": "A COVID-19 pandemic was declared on March 11 by the World Health Organization (WHO). The first cases of COVID-19 were confirmed on January 31 in Sweden and on February 26 in Norway. Despite being similar countries with universal healthcare systems, the governmental approaches to mitigation of the epidemic have varied considerably. Norway initiated a societal lockdown effective from March 12, the same day as the first confirmed death. Sweden has initiated a more laxed and gradual strategy based on the appeal for a strong personal sense of responsibility to mitigate the viral spread. In both countries, the first weeks of preparation has seen a strong reduction in elective surgery, with several implemented principles to mitigate SARS-CoV-2 spread and prepare for surgical care for COVID-19 diseases as needed. This invited leading article gives a brief overview of some of the early experiences of the outbreak in two Scandinavian countries.", "doi": "10.1093/jscr/rjaa131", "pmid": "32395226", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "rjaa131"}, {"db": "pmc", "key": "PMC7202331"}], "notes": [], "created": "2020-11-25T07:59:03.840Z", "modified": "2021-12-06T13:04:20.843Z"}, {"entity": "publication", "iuid": "4d4cde731a184da8be9ae3d417ecb902", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4d4cde731a184da8be9ae3d417ecb902.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4d4cde731a184da8be9ae3d417ecb902"}}, "title": "Dysregulation in mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells", "authors": [{"family": "Appelberg", "given": "Sofia", "initials": "S"}, {"family": "Gupta", "given": "Soham", "initials": "S"}, {"family": "Ambikan", "given": "Anoop T", "initials": "AT"}, {"family": "Mikaeloff", "given": "Flora", "initials": "F"}, {"family": "V\u00e9gv\u00e1ri", "given": "\u00c1kos", "initials": "\u00c1"}, {"family": "Akusj\u00e4rvi", "given": "Sara Svensson", "initials": "SS"}, {"family": "Benfeitas", "given": "Rui", "initials": "R"}, {"family": "Sperk", "given": "Maike", "initials": "M"}, {"family": "St\u00e5hlberg", "given": "Marie", "initials": "M"}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Singh", "given": "Kamal", "initials": "K"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "posted-content", "published": "2020-05-01", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.04.30.070383", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-14T14:58:17.708Z", "modified": "2021-12-06T13:06:02.092Z"}, {"entity": "publication", "iuid": "aef310ad68884b00ad09dff6ca327828", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aef310ad68884b00ad09dff6ca327828.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aef310ad68884b00ad09dff6ca327828"}}, "title": "What does COVID\u201019 distract us from? A migration studies perspective on the inequities of attention", "authors": [{"family": "Della Rosa", "given": "Asia", "initials": "A", "orcid": "0000-0002-2604-0284", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/93497b0315174b4697d5b15e56cd656c.json"}}, {"family": "Goldstein", "given": "Asher", "initials": "A", "orcid": "0000-0003-4314-9596", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/52c678422cb34e36a9974fc180fa6b13.json"}}], "type": "journal-article", "published": "2020-05-00", "journal": {"title": "Soc Anthropol", "issn": "1469-8676", "volume": "28", "issue": "2", "pages": "257-259", "issn-l": null}, "abstract": null, "doi": "10.1111/1469-8676.12899", "pmid": "32836948", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "SOCA12899"}, {"db": "pmc", "key": "PMC7276791"}], "notes": [], "created": "2020-12-07T10:37:28.561Z", "modified": "2021-12-06T13:15:35.718Z"}, {"entity": "publication", "iuid": "fc4e079187234aeaa3ba585e6cbd4fd7", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/fc4e079187234aeaa3ba585e6cbd4fd7.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/fc4e079187234aeaa3ba585e6cbd4fd7"}}, "title": "The Need of Research Initiatives Amidst and After the Covid-19 Pandemic: A Message from the Editors of the EJVES", "authors": [{"family": "Bj\u00f6rck", "given": "Martin", "initials": "M"}, {"family": "Boyle", "given": "Jonathan R", "initials": "JR"}, {"family": "Dick", "given": "Florian", "initials": "F"}], "type": "journal-article", "published": "2020-05-00", "journal": {"title": "Eur J Vasc Endovasc Surg", "issn": "1078-5884", "volume": "59", "issue": "5", "pages": "695-696", "issn-l": null}, "abstract": "Editorial", "doi": "10.1016/j.ejvs.2020.04.002", "pmid": "32303451", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S1078-5884(20)30324-5"}, {"db": "pmc", "key": "PMC7151378"}], "notes": [], "created": "2020-11-22T08:52:45.922Z", "modified": "2021-12-06T13:05:35.086Z"}, {"entity": "publication", "iuid": "0c478d1d514d4c4b9f631e9223d724b0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c478d1d514d4c4b9f631e9223d724b0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c478d1d514d4c4b9f631e9223d724b0"}}, "title": "Saliva testing for COVID-19?", "authors": [{"family": "Sapkota", "given": "D", "initials": "D"}, {"family": "Thapa", "given": "S B", "initials": "SB"}, {"family": "Hass\u00e9us", "given": "B", "initials": "B"}, {"family": "Jensen", "given": "J L", "initials": "JL"}], "type": "journal-article", "published": "2020-05-00", "journal": {"title": "Br Dent J", "issn": "1476-5373", "volume": "228", "issue": "9", "pages": "658-659", "issn-l": null}, "abstract": null, "doi": "10.1038/s41415-020-1594-7", "pmid": "32385433", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41415-020-1594-7"}], "notes": [], "created": "2020-12-10T07:41:02.939Z", "modified": "2021-12-06T13:05:14.408Z"}, {"entity": "publication", "iuid": "799fba058334420eb8a7605051fb1b71", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/799fba058334420eb8a7605051fb1b71.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/799fba058334420eb8a7605051fb1b71"}}, "title": "Protecting children in low-income and middle-income countries from COVID-19", "authors": [{"family": "Ahmed", "given": "Salahuddin", "initials": "S", "orcid": "0000-0001-6771-0638", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/36afb59c938e4bc8bbcaf428373622c4.json"}}, {"family": "Mvalo", "given": "Tisungane", "initials": "T"}, {"family": "Akech", "given": "Samuel", "initials": "S"}, {"family": "Agweyu", "given": "Ambrose", "initials": "A"}, {"family": "Baker", "given": "Kevin", "initials": "K"}, {"family": "Bar-Zeev", "given": "Naor", "initials": "N"}, {"family": "Campbell", "given": "Harry", "initials": "H"}, {"family": "Checkley", "given": "William", "initials": "W"}, {"family": "Chisti", "given": "Mohammod Jobayer", "initials": "MJ"}, {"family": "Colbourn", "given": "Tim", "initials": "T", "orcid": "0000-0002-6917-6552", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a2cccce75e4b4602ab197604cb444a0a.json"}}, {"family": "Cunningham", "given": "Steve", "initials": "S"}, {"family": "Duke", "given": "Trevor", "initials": "T"}, {"family": "English", "given": "Mike", "initials": "M", "orcid": "0000-0002-7427-0826", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d680cdafc8854a619f1919652dd16aed.json"}}, {"family": "Falade", "given": "Adegoke G", "initials": "AG"}, {"family": "Fancourt", "given": "Nicholas SS", "initials": "NS", "orcid": "0000-0002-1772-9960", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/a5c4d94e20e74d02a6ee3f4287e0d588.json"}}, {"family": "Ginsburg", "given": "Amy S", "initials": "AS"}, {"family": "Graham", "given": "Hamish R", "initials": "HR", "orcid": "0000-0003-2461-0463", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/2d2d23d0b7dc40f3979a4342d3898649.json"}}, {"family": "Gray", "given": "Diane M", "initials": "DM"}, {"family": "Gupta", "given": "Madhu", "initials": "M"}, {"family": "Hammitt", "given": "Laura", "initials": "L"}, {"family": "Hesseling", "given": "Anneke C", "initials": "AC"}, {"family": "Hooli", "given": "Shubhada", "initials": "S", "orcid": "0000-0003-4596-448X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/20d63548cf4340a2a8e3d092113580d7.json"}}, {"family": "Johnson", "given": "Abdul Wahab BR", "initials": "AWB"}, {"family": "King", "given": "Carina", "initials": "C"}, {"family": "Kirby", "given": "Miles A", "initials": "MA"}, {"family": "Lanata", "given": "Claudio F", "initials": "CF"}, {"family": "Lufesi", "given": "Norman", "initials": "N"}, {"family": "Mackenzie", "given": "Grant A", "initials": "GA"}, {"family": "McCracken", "given": "John P", "initials": "JP"}, {"family": "Moschovis", "given": "Peter P", "initials": "PP", "orcid": "0000-0002-9664-5959", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/5df313713eda423196bc8f01c3cccd6a.json"}}, {"family": "Nair", "given": "Harish", "initials": "H"}, {"family": "Oviawe", "given": "Osawaru", "initials": "O"}, {"family": "Pomat", "given": "William S", "initials": "WS"}, {"family": "Santosham", "given": "Mathuram", "initials": "M"}, {"family": "Seddon", "given": "James A", "initials": "JA"}, {"family": "Thahane", "given": "Lineo Keneuoe", "initials": "LK"}, {"family": "Wahl", "given": "Brian", "initials": "B", "orcid": "0000-0002-0037-7364", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/9a1b355e68f949a3964fac2381982327.json"}}, {"family": "Van der Zalm", "given": "Marieke", "initials": "M"}, {"family": "Verwey", "given": "Charl", "initials": "C"}, {"family": "Yoshida", "given": "Lay Myint", "initials": "LM"}, {"family": "Zar", "given": "Heather J", "initials": "HJ"}, {"family": "Howie", "given": "Stephen RC", "initials": "SR"}, {"family": "McCollum", "given": "Eric D", "initials": "ED", "orcid": "0000-0002-1872-5566", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/95a0edabce86477287b3354ea4861a33.json"}}], "type": "journal-article", "published": "2020-05-00", "journal": {"title": "BMJ Glob Health", "issn": "2059-7908", "volume": "5", "issue": "5", "pages": "e002844", "issn-l": "2059-7908"}, "abstract": "Editorial", "doi": "10.1136/bmjgh-2020-002844", "pmid": "32461228", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "bmjgh-2020-002844"}, {"db": "pmc", "key": "PMC7254117"}], "notes": [], "created": "2020-11-25T09:21:02.315Z", "modified": "2021-12-06T13:04:54.117Z"}, {"entity": "publication", "iuid": "a25c8dcffb2040b787a0f1d3621f4dce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a25c8dcffb2040b787a0f1d3621f4dce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a25c8dcffb2040b787a0f1d3621f4dce"}}, "title": "Practice recommendations for lung cancer radiotherapy during the COVID-19 pandemic: An ESTRO-ASTRO consensus statement.", "authors": [{"family": "Guckenberger", "given": "Matthias", "initials": "M", "orcid": "0000-0002-7146-9071", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/09684c7ae622448f99208130af9e282e.json"}}, {"family": "Belka", "given": "Claus", "initials": "C"}, {"family": "Bezjak", "given": "Andrea", "initials": "A"}, {"family": "Bradley", "given": "Jeffrey", "initials": "J"}, {"family": "Daly", "given": "Megan E", "initials": "ME", "orcid": "0000-0001-7308-6149", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dc0b3418cf5d4e1897814f629298d06e.json"}}, {"family": "DeRuysscher", "given": "Dirk", "initials": "D"}, {"family": "Dziadziuszko", "given": "Rafal", "initials": "R", "orcid": "0000-0001-8080-9843", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e81c6277a79c41bca7fa5d9a83bc4e6e.json"}}, {"family": "Faivre-Finn", "given": "Corinne", "initials": "C", "orcid": "0000-0001-5617-9781", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e12bb7f823e74c3bb7e16a73b04d594c.json"}}, {"family": "Flentje", "given": "Michael", "initials": "M"}, {"family": "Gore", "given": "Elizabeth", "initials": "E"}, {"family": "Higgins", "given": "Kristin A", "initials": "KA"}, {"family": "Iyengar", "given": "Puneeth", "initials": "P"}, {"family": "Kavanagh", "given": "Brian D", "initials": "BD", "orcid": "0000-0001-5579-1725", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c7c5b8b6b8804b22896a1d2efcca9285.json"}}, {"family": "Kumar", "given": "Sameera", "initials": "S"}, {"family": "Le Pechoux", "given": "Cecile", "initials": "C"}, {"family": "Lievens", "given": "Yolande", "initials": "Y"}, {"family": "Lindberg", "given": "Karin", "initials": "K"}, {"family": "McDonald", "given": "Fiona", "initials": "F"}, {"family": "Ramella", "given": "Sara", "initials": "S"}, {"family": "Rengan", "given": "Ramesh", "initials": "R", "orcid": "0000-0001-5379-536X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/6006bff18bfe4dd38cce342cf4008e28.json"}}, {"family": "Ricardi", "given": "Umberto", "initials": "U", "orcid": "0000-0003-4406-7621", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/4592c02990ab440790e7391977331369.json"}}, {"family": "Rimner", "given": "Andreas", "initials": "A"}, {"family": "Rodrigues", "given": "George B", "initials": "GB"}, {"family": "Schild", "given": "Steven E", "initials": "SE"}, {"family": "Senan", "given": "Suresh", "initials": "S"}, {"family": "Simone", "given": "Charles B", "initials": "CB 2nd"}, {"family": "Slotman", "given": "Ben J", "initials": "BJ", "orcid": "0000-0002-9902-4592", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c53ea83c8d964c08b08ec6efe7d782cb.json"}}, {"family": "Stuschke", "given": "Martin", "initials": "M"}, {"family": "Videtic", "given": "Greg", "initials": "G"}, {"family": "Widder", "given": "Joachim", "initials": "J", "orcid": "0000-0002-9972-6690", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/12f78661cf184d809e1208fdb742cdbb.json"}}, {"family": "Yom", "given": "Sue S", "initials": "SS", "orcid": "0000-0002-0779-7476", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/dcd04dd7ffd94ac79534245657af08ca.json"}}, {"family": "Palma", "given": "David", "initials": "D", "orcid": "0000-0002-9542-0627", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/c33cf08374fb445887d22f67b62f1792.json"}}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "Radiother Oncol", "issn": "1879-0887", "volume": "146", "issue": null, "pages": "223-229", "issn-l": "0167-8140"}, "abstract": "The COVID-19 pandemic has caused radiotherapy resource pressures and led to increased risks for lung cancer patients and healthcare staff. An international group of experts in lung cancer radiotherapy established this practice recommendation pertaining to whether and how to adapt radiotherapy for lung cancer in the COVID-19 pandemic.\n\nFor this ESTRO & ASTRO endorsed project, 32 experts in lung cancer radiotherapy contributed to a modified Delphi consensus process. We assessed potential adaptations of radiotherapy in two pandemic scenarios. The first, an early pandemic scenario of risk mitigation, is characterized by an altered risk-benefit ratio of radiotherapy for lung cancer patients due to their increased susceptibility for severe COVID-19 infection, and minimization of patient travelling and exposure of radiotherapy staff. The second, a later pandemic scenario, is characterized by reduced radiotherapy resources requiring patient triage. Six common lung cancer cases were assessed for both scenarios: peripherally located stage I NSCLC, locally advanced NSCLC, postoperative radiotherapy after resection of pN2 NSCLC, thoracic radiotherapy and prophylactic cranial irradiation for limited stage SCLC and palliative thoracic radiotherapy for stage IV NSCLC.\n\nIn a risk-mitigation pandemic scenario, efforts should be made not to compromise the prognosis of lung cancer patients by departing from guideline-recommended radiotherapy practice. In that same scenario, postponement or interruption of radiotherapy treatment of COVID-19 positive patients is generally recommended to avoid exposure of cancer patients and staff to an increased risk of COVID-19 infection. In a severe pandemic scenario characterized by reduced resources, if patients must be triaged, important factors for triage include potential for cure, relative benefit of radiation, life expectancy, and performance status. Case-specific consensus recommendations regarding multimodality treatment strategies and fractionation of radiotherapy are provided.\n\nThis joint ESTRO-ASTRO practice recommendation established pragmatic and balanced consensus recommendations in common clinical scenarios of radiotherapy for lung cancer in order to address the challenges of the COVID-19 pandemic.", "doi": "10.1016/j.radonc.2020.04.001", "pmid": "32342863", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0167-8140(20)30182-1"}, {"db": "pmc", "key": "PMC7252074"}], "notes": [], "created": "2020-11-25T07:13:12.107Z", "modified": "2021-12-06T13:03:46.407Z"}, {"entity": "publication", "iuid": "d0ce868b1d99450081c6108a163f3209", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/d0ce868b1d99450081c6108a163f3209.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/d0ce868b1d99450081c6108a163f3209"}}, "title": "Managing COVID-19 in the oncology clinic and avoiding the distraction effect.", "authors": [{"family": "Cortiula", "given": "F", "initials": "F"}, {"family": "Pettke", "given": "A", "initials": "A"}, {"family": "Bartoletti", "given": "M", "initials": "M"}, {"family": "Puglisi", "given": "F", "initials": "F"}, {"family": "Helleday", "given": "T", "initials": "T"}], "type": "editorial", "published": "2020-05-00", "journal": {"title": "Annals of Oncology", "issn": "1569-8041", "volume": "31", "issue": "5", "pages": "553-555", "issn-l": "0923-7534"}, "abstract": null, "doi": "10.1016/j.annonc.2020.03.286", "pmid": "32201224", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S0923-7534(20)36373-0"}, {"db": "pmc", "key": "PMC7174827"}], "notes": [], "created": "2020-11-04T13:17:26.873Z", "modified": "2021-12-06T13:03:18.096Z"}, {"entity": "publication", "iuid": "915fc7aead7f44f0b92cddf6e2657588", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/915fc7aead7f44f0b92cddf6e2657588.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/915fc7aead7f44f0b92cddf6e2657588"}}, "title": "Management of Advanced Therapies in Parkinson's Disease Patients in Times of Humanitarian Crisis: The COVID-19 Experience.", "authors": [{"family": "Fasano", "given": "Alfonso", "initials": "A"}, {"family": "Antonini", "given": "Angelo", "initials": "A"}, {"family": "Katzenschlager", "given": "Regina", "initials": "R"}, {"family": "Krack", "given": "Paul", "initials": "P"}, {"family": "Odin", "given": "Per", "initials": "P"}, {"family": "Evans", "given": "Andrew H", "initials": "AH"}, {"family": "Foltynie", "given": "Thomas", "initials": "T"}, {"family": "Volkmann", "given": "Jens", "initials": "J"}, {"family": "Merello", "given": "Marcelo", "initials": "M"}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "Mov Disord Clin Pract", "issn": "2330-1619", "volume": "7", "issue": "4", "pages": "361-372", "issn-l": null}, "abstract": "Although the COVID-19 pandemic is affecting a relatively small proportion of the global population, its effects have already reached everyone. The pandemic has the potential to differentially disadvantage chronically ill patients, including those with Parkinson's disease (PD). The first health care reaction has been to limit access to clinics and neurology wards to preserve fragile patients with PD from being infected. In some regions, the shortage of medical staff has also forced movement disorders neurologists to provide care for patients with COVID-19.\n\nTo share the experience of various movement disorder neurologists operating in different world regions and provide a common approach to patients with PD, with a focus on those already on advanced therapies, which may serve as guidance in the current pandemic and for emergency situations that we may face in the future.\n\nMost of us were unprepared to deal with this condition given that in many health care systems, telemedicine has been only marginally available or only limited to email or telephone contacts. In addition, to ensure sufficient access to intensive care unit beds, most elective procedures (including deep brain stimulation or the initiation of infusion therapies) have been postponed. We all hope there will soon be a time when we will return to more regular hospital schedules. However, we should consider this crisis as an opportunity to change our approach and encourage our hospitals and health care systems to facilitate the remote management of chronic neurological patients, including those with advanced PD.", "doi": "10.1002/mdc3.12965", "pmid": "32373652", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "MDC312965"}, {"db": "pmc", "key": "PMC7197306"}], "notes": [], "created": "2020-12-10T07:32:13.596Z", "modified": "2020-12-10T07:32:13.608Z"}, {"entity": "publication", "iuid": "6880115da67342c8aee2da2101ee00ee", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6880115da67342c8aee2da2101ee00ee.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6880115da67342c8aee2da2101ee00ee"}}, "title": "ISUOG Safety Committee Position Statement on safe performance of obstetric and gynecological scans and equipment cleaning in context of COVID-19.", "authors": [{"family": "Poon", "given": "L C", "initials": "LC"}, {"family": "Abramowicz", "given": "J S", "initials": "JS"}, {"family": "Dall'Asta", "given": "A", "initials": "A"}, {"family": "Sande", "given": "R", "initials": "R"}, {"family": "Ter Haar", "given": "G", "initials": "G"}, {"family": "Mar\u0161al", "given": "K", "initials": "K"}, {"family": "Brezinka", "given": "C", "initials": "C"}, {"family": "Miloro", "given": "P", "initials": "P"}, {"family": "Basseal", "given": "J", "initials": "J"}, {"family": "Westerway", "given": "S C", "initials": "SC"}, {"family": "Abu-Rustum", "given": "R S", "initials": "RS"}, {"family": "Lees", "given": "C", "initials": "C"}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "Ultrasound Obstet Gynecol", "issn": "1469-0705", "volume": "55", "issue": "5", "pages": "709-712", "issn-l": null}, "abstract": null, "doi": "10.1002/uog.22027", "pmid": "32207189", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-08T06:57:10.479Z", "modified": "2020-12-10T08:59:30.636Z"}, {"entity": "publication", "iuid": "6da4506c756d45aa94417f1e53816578", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6da4506c756d45aa94417f1e53816578.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6da4506c756d45aa94417f1e53816578"}}, "title": "D\u00e9j\u00e0 vu: Stimulating open drug discovery for SARS-CoV-2.", "authors": [{"family": "Ekins", "given": "Sean", "initials": "S"}, {"family": "Mottin", "given": "Melina", "initials": "M"}, {"family": "Ramos", "given": "Paulo R P S", "initials": "PRPS"}, {"family": "Sousa", "given": "Bruna K P", "initials": "BKP"}, {"family": "Neves", "given": "Bruno Junior", "initials": "BJ"}, {"family": "Foil", "given": "Daniel H", "initials": "DH"}, {"family": "Zorn", "given": "Kimberley M", "initials": "KM"}, {"family": "Braga", "given": "Rodolpho C", "initials": "RC"}, {"family": "Coffee", "given": "Megan", "initials": "M"}, {"family": "Southan", "given": "Christopher", "initials": "C"}, {"family": "Puhl", "given": "Ana C", "initials": "AC"}, {"family": "Andrade", "given": "Carolina Horta", "initials": "CH"}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "Drug Discov Today", "issn": "1878-5832", "volume": "25", "issue": "5", "pages": "928-941", "issn-l": null}, "abstract": "In the past decade we have seen two major Ebola virus outbreaks in Africa, the Zika virus in Brazil and the Americas and the current pandemic of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There is a strong sense of d\u00e9j\u00e0 vu because there are still no effective treatments. In the COVID-19 pandemic, despite being a new virus, there are already drugs suggested as active in in vitro assays that are being repurposed in clinical trials. Promising SARS-CoV-2 viral targets and computational approaches are described and discussed. Here, we propose, based on open antiviral drug discovery approaches for previous outbreaks, that there could still be gaps in our approach to drug discovery.", "doi": "10.1016/j.drudis.2020.03.019", "pmid": "32320852", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1359-6446(20)30145-8"}, {"db": "pmc", "key": "PMC7167229"}], "notes": [], "created": "2020-11-30T15:55:34.499Z", "modified": "2020-11-30T15:55:34.523Z"}, {"entity": "publication", "iuid": "66b254f7d31346739b916455b018cd88", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/66b254f7d31346739b916455b018cd88.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/66b254f7d31346739b916455b018cd88"}}, "title": "Could severe COVID-19 be considered a complementopathy?", "authors": [{"family": "Chatzidionysiou", "given": "Katerina", "initials": "K", "orcid": "0000-0002-2669-1247", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e5cbb9ca8214426084a1def47e9029b2.json"}}, {"family": "Svenungsson", "given": "Elisabet", "initials": "E"}, {"family": "Faustini", "given": "Francesca", "initials": "F"}], "type": "journal-article", "published": "2020-05-00", "journal": {"title": "Lupus Sci Med", "issn": "2053-8790", "volume": "7", "issue": "1", "pages": "e000415", "issn-l": "2053-8790"}, "abstract": null, "doi": "10.1136/lupus-2020-000415", "pmid": "32430402", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "7/1/e000415"}, {"db": "pmc", "key": "PMC7246101"}], "notes": [], "created": "2020-11-25T09:07:20.316Z", "modified": "2021-12-06T13:01:45.301Z"}, {"entity": "publication", "iuid": "ee1e8b1ebe574af7a398a7a45d56a825", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ee1e8b1ebe574af7a398a7a45d56a825.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ee1e8b1ebe574af7a398a7a45d56a825"}}, "title": "Classification system and case definition for SARS-CoV-2 infection in pregnant women, fetuses, and neonates.", "authors": [{"family": "Shah", "given": "Prakesh S", "initials": "PS"}, {"family": "Diambomba", "given": "Yenge", "initials": "Y"}, {"family": "Acharya", "given": "Ganesh", "initials": "G"}, {"family": "Morris", "given": "Shaun K", "initials": "SK"}, {"family": "Bitnun", "given": "Ari", "initials": "A"}], "type": "editorial", "published": "2020-05-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "5", "pages": "565-568", "issn-l": "0001-6349"}, "abstract": null, "doi": "10.1111/aogs.13870", "pmid": "32277845", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7262318"}], "notes": [], "created": "2020-11-23T11:28:46.202Z", "modified": "2020-12-09T14:48:38.570Z"}, {"entity": "publication", "iuid": "63e8720413dc48c5b2a905b7a43ef905", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/63e8720413dc48c5b2a905b7a43ef905.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/63e8720413dc48c5b2a905b7a43ef905"}}, "title": "Caring for patients with cancer in the COVID-19 era.", "authors": [{"family": "van de Haar", "given": "Joris", "initials": "J"}, {"family": "Hoes", "given": "Louisa R", "initials": "LR"}, {"family": "Coles", "given": "Charlotte E", "initials": "CE"}, {"family": "Seamon", "given": "Kenneth", "initials": "K"}, {"family": "Fr\u00f6hling", "given": "Stefan", "initials": "S"}, {"family": "J\u00e4ger", "given": "Dirk", "initials": "D"}, {"family": "Valenza", "given": "Franco", "initials": "F"}, {"family": "de Braud", "given": "Filippo", "initials": "F"}, {"family": "De Petris", "given": "Luigi", "initials": "L"}, {"family": "Bergh", "given": "Jonas", "initials": "J"}, {"family": "Ernberg", "given": "Ingemar", "initials": "I"}, {"family": "Besse", "given": "Benjamin", "initials": "B"}, {"family": "Barlesi", "given": "Fabrice", "initials": "F"}, {"family": "Garralda", "given": "Elena", "initials": "E"}, {"family": "Piris-Gim\u00e9nez", "given": "Alejandro", "initials": "A"}, {"family": "Baumann", "given": "Michael", "initials": "M"}, {"family": "Apolone", "given": "Giovanni", "initials": "G"}, {"family": "Soria", "given": "Jean Charles", "initials": "JC"}, {"family": "Tabernero", "given": "Josep", "initials": "J"}, {"family": "Caldas", "given": "Carlos", "initials": "C"}, {"family": "Voest", "given": "Emile E", "initials": "EE"}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "Nat Med", "issn": "1546-170X", "volume": "26", "issue": "5", "pages": "665-671", "issn-l": "1078-8956"}, "abstract": "The current COVID-19 pandemic challenges oncologists to profoundly re-organize oncological care in order to dramatically reduce hospital visits and admissions and therapy-induced immune-related complications without compromising cancer outcomes. Since COVID-19 is a novel disease, guidance by scientific evidence is often unavailable, and impactful decisions are inevitably made on the basis of expert opinions. Here we report how the seven comprehensive cancer centers of Cancer Core Europe have organized their healthcare systems at an unprecedented scale and pace to make their operations 'pandemic proof'. We identify and discuss many commonalities, but also important local differences, and pinpoint critical research priorities to enable evidence-based remodeling of cancer care during the COVID-19 pandemic. Also, we discuss how the current situation offers a unique window of opportunity for assessing the effects of de-escalating anticancer regimens, which may fast-forward the development of more-refined and less-toxic treatments. By sharing our joint experiences, we offer a roadmap for proceeding and aim to mobilize the global research community to generate the data that are critically needed to offer the best possible care to patients.", "doi": "10.1038/s41591-020-0874-8", "pmid": "32405058", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41591-020-0874-8"}], "notes": [], "created": "2020-11-25T08:02:57.207Z", "modified": "2020-11-30T09:07:56.925Z"}, {"entity": "publication", "iuid": "0c354790c7ff4f10b5b8a21467a49ea5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0c354790c7ff4f10b5b8a21467a49ea5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0c354790c7ff4f10b5b8a21467a49ea5"}}, "title": "Burden and prevalence of prognostic factors for severe COVID-19 in Sweden.", "authors": [{"family": "G\u00e9mes", "given": "Katalin", "initials": "K", "orcid": "0000-0003-3335-7850", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/fe866acb6ee744e7a413be9348fd3463.json"}}, {"family": "Talb\u00e4ck", "given": "Mats", "initials": "M"}, {"family": "Modig", "given": "Karin", "initials": "K"}, {"family": "Ahlbom", "given": "Anders", "initials": "A"}, {"family": "Berglund", "given": "Anita", "initials": "A"}, {"family": "Feychting", "given": "Maria", "initials": "M"}, {"family": "Matthews", "given": "Anthony A", "initials": "AA", "orcid": "0000-0002-1290-271X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d8d087bad1264a57b5e9d6e3c264bf21.json"}}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "Eur J Epidemiol", "issn": "1573-7284", "issn-l": "0393-2990", "volume": "35", "issue": "5", "pages": "401-409"}, "abstract": "The World Health Organization and European Centre for Disease Prevention and Control suggest that individuals over the age of 70 years or with underlying cardiovascular disease, cancer, chronic obstructive pulmonary disease, asthma, or diabetes are at increased risk of severe COVID-19. However, the prevalence of these prognostic factors is unknown in many countries. We aimed to describe the burden and prevalence of prognostic factors of severe COVID-19 at national and county level in Sweden. We calculated the burden and prevalence of prognostic factors for severe COVID-19 based on records from the Swedish national health care and population registers for 3 years before 1st January 2016. 9,624,428 individuals were included in the study population. 22.1% had at least one prognostic factor for severe COVID-19 (2,131,319 individuals), and 1.6% had at least three factors (154,746 individuals). The prevalence of underlying medical conditions ranged from 0.8% with chronic obstructive pulmonary disease (78,516 individuals) to 7.4% with cardiovascular disease (708,090 individuals), and the county specific prevalence of at least one prognostic factor ranged from 19.2% in Stockholm (416,988 individuals) to 25.9% in Kalmar (60,005 individuals). We show that one in five individuals in Sweden is at increased risk of severe COVID-19. When compared with the critical care capacity at a local and national level, these results can aid authorities in optimally planning healthcare resources during the current pandemic. Findings can also be applied to underlying assumptions of disease burden in modelling efforts to support COVID-19 planning.", "doi": "10.1007/s10654-020-00646-z", "pmid": "32424571", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7233678"}, {"db": "pii", "key": "10.1007/s10654-020-00646-z"}], "notes": [], "created": "2021-06-14T06:37:37.102Z", "modified": "2023-06-19T14:52:50.448Z"}, {"entity": "publication", "iuid": "5506caef258d4d358aebefa4269ad746", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5506caef258d4d358aebefa4269ad746.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5506caef258d4d358aebefa4269ad746"}}, "title": "Allergic respiratory disease care in the COVID-19 era: A EUFOREA statement.", "authors": [{"family": "Scadding", "given": "Glenis K", "initials": "GK"}, {"family": "Hellings", "given": "Peter W", "initials": "PW"}, {"family": "Bachert", "given": "Claus", "initials": "C"}, {"family": "Bjermer", "given": "Leif", "initials": "L"}, {"family": "Diamant", "given": "Zuzana", "initials": "Z"}, {"family": "Gevaert", "given": "Philippe", "initials": "P"}, {"family": "Kjeldsen", "given": "Anette", "initials": "A"}, {"family": "Kleine-Tebbe", "given": "Jorge", "initials": "J"}, {"family": "Klimek", "given": "Ludger", "initials": "L"}, {"family": "Muraro", "given": "Antonella", "initials": "A"}, {"family": "Roberts", "given": "Graham", "initials": "G"}, {"family": "Steinsvik", "given": "Andreas", "initials": "A"}, {"family": "Wagenmann", "given": "Martin", "initials": "M"}, {"family": "Wahn", "given": "Ulrich", "initials": "U"}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "World Allergy Organ J", "issn": "1939-4551", "volume": "13", "issue": "5", "pages": "100124", "issn-l": "1939-4551"}, "abstract": "Spring and Summer 2020 are unique in that the challenges of care for those suffering from pollen allergy coincide with the COVID-19 pandemic. Several considerations are important to allow optimal care of allergic rhinitis (AR) and asthma and hence prevention of coronavirus spread through sneezing, rhinorrhoea, and coughing. This compact overview of recommendations by the EUFOREA expert teams on allergic airway diseases and allergen-specific immunotherapy (AIT) is based on investigation of the current COVID-19 literature in association with the key words above and shared clinical experience of the experts involved. It deals with similarities and differences between AR and coronavirus infection, specific recommendations for allergic disease care in the COVID-19 era, including guidance on AIT.", "doi": "10.1016/j.waojou.2020.100124", "pmid": "32426089", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "S1939-4551(20)30027-2"}, {"db": "pii", "key": "100124"}, {"db": "pmc", "key": "PMC7229977"}], "notes": [], "created": "2020-11-25T08:35:35.107Z", "modified": "2020-12-09T11:41:32.455Z"}, {"entity": "publication", "iuid": "311580f756de4896bcebd20ebf489053", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/311580f756de4896bcebd20ebf489053.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/311580f756de4896bcebd20ebf489053"}}, "title": "A global recommendation for restrictive provision of fertility treatments during the COVID-19 pandemic.", "authors": [{"family": "Rodriguez-Wallberg", "given": "Kenny A", "initials": "KA"}, {"family": "Wikander", "given": "Ida", "initials": "I"}], "type": "editorial", "published": "2020-05-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "1600-0412", "volume": "99", "issue": "5", "pages": "569-570", "issn-l": "0001-6349"}, "abstract": "Editorial", "doi": "10.1111/aogs.13851", "pmid": "32270485", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7262212"}], "notes": [], "created": "2020-11-22T17:11:24.352Z", "modified": "2020-12-09T12:02:52.026Z"}, {"entity": "publication", "iuid": "aa52c6883f014263ae471d5182574d50", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/aa52c6883f014263ae471d5182574d50.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/aa52c6883f014263ae471d5182574d50"}}, "title": "[Covid-19 - deaths and analysis].", "authors": [{"family": "Modig", "given": "Karin", "initials": "K"}, {"family": "Ahlbom", "given": "Anders", "initials": "A"}, {"family": "Matthews", "given": "Anthony", "initials": "A"}], "type": "journal article", "published": "2020-04-30", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "volume": "117", "issue": null, "issn-l": "0023-7205"}, "abstract": "Mortality from Covid-19 is monitored in detail and compared between countries with different strategies against the virus. There is, however, often a lack of understanding of what is required in terms of measures and interpretation to enable correct comparisons. The number of deaths from Covid-19 is affected by the testing strategy and many other things that differ between countries. Therefore, today, the most reliable source for monitoring and comparing mortality from Covid-19 is total mortality. In Sweden, there is good correspondence of Covid-19 deaths and total mortality, with a tendency to a higher total mortality indicating some under-reporting of Covid-19 mortality.", "doi": null, "pmid": "32365212", "labels": {"Category: Public Health": null, "Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "F3XL"}], "notes": [], "created": "2020-12-10T07:26:31.854Z", "modified": "2023-01-13T14:49:29.532Z"}, {"entity": "publication", "iuid": "39986cc3e1564ff185d21484709b3b5c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/39986cc3e1564ff185d21484709b3b5c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/39986cc3e1564ff185d21484709b3b5c"}}, "title": "Physical Activity During the Coronavirus (COVID-19) Pandemic: Prevention of a Decline in Metabolic and Immunological Functions", "authors": [{"family": "Jakobsson", "given": "Johan", "initials": "J"}, {"family": "Malm", "given": "Christer", "initials": "C"}, {"family": "Furberg", "given": "Maria", "initials": "M"}, {"family": "Ekelund", "given": "Ulf", "initials": "U"}, {"family": "Svensson", "given": "Michael", "initials": "M"}], "type": "journal-article", "published": "2020-04-30", "journal": {"title": "Front Sports Act Living", "issn": "2624-9367", "volume": "2", "issue": null, "pages": "57", "issn-l": null}, "abstract": null, "doi": "10.3389/fspor.2020.00057", "pmid": "33345048", "labels": {"Type: Journal article": null, "Category: Public Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7739799"}], "notes": [], "created": "2021-01-07T13:31:10.740Z", "modified": "2021-12-06T12:58:44.937Z"}, {"entity": "publication", "iuid": "68ad55ebf84544769e6502910e61ca19", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/68ad55ebf84544769e6502910e61ca19.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/68ad55ebf84544769e6502910e61ca19"}}, "title": "[Bats and humans].", "authors": [{"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-04-29", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": "Coronavirus (CoV) species are very common among animals, especially bats. The last two decades three large CoV outbreaks have appeared among humans; Severe Adult Respiratory Syndrome (SARS-1) in 2003, Middle East Respiratory Syndrome (MERS) in 2012 and SARS-2 in 2019, (COVID19). Also a large epidemic among swine, Swine Acute Diarrhea Syndrome (SADS) appeared in 2017 in China. There is a pool of coronavirus among bats which have the potential to infect humans through the ACE2 receptor, and new human epidemics can be expected. Therefore it is of great importance to develop new antivirals and vaccines against CoV as well as to improve the global infectious disease control of these infections.", "doi": null, "pmid": "32365214", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "F3UA"}], "notes": [], "created": "2020-11-25T07:21:34.085Z", "modified": "2021-12-06T12:57:40.712Z"}, {"entity": "publication", "iuid": "ce2f2dd752d04c168bef529206081d55", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/ce2f2dd752d04c168bef529206081d55.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/ce2f2dd752d04c168bef529206081d55"}}, "title": "Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs.", "authors": [{"family": "Neogi", "given": "Ujjwal", "initials": "U"}, {"family": "Hill", "given": "Kyle J", "initials": "KJ"}, {"family": "Ambikan", "given": "Anoop T", "initials": "AT"}, {"family": "Heng", "given": "Xiao", "initials": "X"}, {"family": "Quinn", "given": "Thomas P", "initials": "TP"}, {"family": "Byrareddy", "given": "Siddappa N", "initials": "SN"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Sarafianos", "given": "Stefan G", "initials": "SG"}, {"family": "Singh", "given": "Kamal", "initials": "K"}], "type": "journal article", "published": "2020-04-26", "journal": {"title": "Pathogens", "issn": "2076-0817", "issn-l": "2076-0817", "volume": "9", "issue": "5", "pages": null}, "abstract": "Coronaviruses (CoVs) are positive-stranded RNA viruses that infect humans and animals. Infection by CoVs such as HCoV-229E, -NL63, -OC43 and -HKU1 leads to the common cold, short lasting rhinitis, cough, sore throat and fever. However, CoVs such as Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and the newest SARS-CoV-2 (the causative agent of COVID-19) lead to severe and deadly diseases with mortality rates ranging between ~1 to 35% depending on factors such as age and pre-existing conditions. Despite continuous global health threats to humans, there are no approved vaccines or drugs targeting human CoVs, and the recent outbreak of COVID-19 emphasizes an urgent need for therapeutic interventions. Using computational and bioinformatics tools, here we present the feasibility of reported broad-spectrum RNA polymerase inhibitors as anti- SARS-CoV-2 drugs targeting its main RNA polymerase, suggesting that investigational and approved nucleoside RNA polymerase inhibitors have potential as anti-SARS-CoV-2 drugs. However, we note that it is also possible for SARS-CoV-2 to evolve and acquire drug resistance mutations against these nucleoside inhibitors.", "doi": "10.3390/pathogens9050320", "pmid": "32357471", "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Biochemistry": null, "Category: Drug Discovery": null}, "xrefs": [{"db": "pii", "key": "pathogens9050320"}, {"db": "pmc", "key": "PMC7281371"}], "notes": [], "created": "2020-11-25T07:17:57.790Z", "modified": "2021-02-26T08:45:25.910Z"}, {"entity": "publication", "iuid": "3271a08268724743b19292818e1e1faa", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3271a08268724743b19292818e1e1faa.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3271a08268724743b19292818e1e1faa"}}, "title": "The unsynchronized changes of CT image and nucleic acid detection in COVID-19: reports the two cases from Gansu, China.", "authors": [{"family": "Gao", "given": "Jing", "initials": "J"}, {"family": "Liu", "given": "Jun-Qiang", "initials": "JQ"}, {"family": "Wen", "given": "Heng-Jun", "initials": "HJ"}, {"family": "Liu", "given": "Hua", "initials": "H"}, {"family": "Hu", "given": "Wei-Dong", "initials": "WD"}, {"family": "Han", "given": "Xia", "initials": "X"}, {"family": "Li", "given": "Chuan-Xing", "initials": "CX"}, {"family": "Wang", "given": "Xiao-Jun", "initials": "XJ"}], "type": "case reports", "published": "2020-04-22", "journal": {"title": "Respir Res", "issn": "1465-993X", "volume": "21", "issue": "1", "pages": "96", "issn-l": "1465-9921"}, "abstract": "The novel coronavirus disease (COVID-19) outbreak started in December 2019 in Wuhan, China, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The CT image is used to assess the disease progress, whereas the continued two times of negative results from SARS-CoV-2 nucleic acid detection had been considered as a criterion for ending antiviral treatment. We compared the two COVID-19 cases with similar backgrounds and CT image repeated intervals under treatment. Our report highlighted the unsynchronized expression in the changes of CT image and nucleic acid detection in COVID-19, and lasting positive nucleic acid test result in patients recovered from pneumonia. It may be contributed to recognize the disease and improve prevention.", "doi": "10.1186/s12931-020-01363-7", "pmid": "32321530", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "NA", "key": "Provided in the article: CT images for 2 patients over 12 days", "description": null}], "notes": [], "created": "2020-11-23T11:43:52.411Z", "modified": "2021-02-26T08:45:48.033Z"}, {"entity": "publication", "iuid": "0ec3865d29d940b4ae522d567b465ae1", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0ec3865d29d940b4ae522d567b465ae1.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0ec3865d29d940b4ae522d567b465ae1"}}, "title": "Systematic Review of Important Viral Diseases in Africa in Light of the \u2018One Health\u2019 Concept", "authors": [{"family": "Chauhan", "given": "Ravendra P", "initials": "RP", "orcid": "0000-0002-4674-8255", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/0d72198d117f42e094daefc52e6d8dfd.json"}}, {"family": "Dessie", "given": "Zelalem G", "initials": "ZG", "orcid": "0000-0001-9056-6822", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aef29117960a411cbfa4718222c2f690.json"}}, {"family": "Noreddin", "given": "Ayman", "initials": "A", "orcid": "0000-0003-4899-1168", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/d6ff11be70974f57aedb0646be4e17c1.json"}}, {"family": "El Zowalaty", "given": "Mohamed E", "initials": "ME", "orcid": "0000-0002-1056-4761", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/58d2f06f64154a2f9b5b22ffbb7518a3.json"}}], "type": "journal-article", "published": "2020-04-20", "journal": {"title": "Pathogens", "issn": "2076-0817", "volume": "9", "issue": "4", "pages": "301", "issn-l": "2076-0817"}, "abstract": "Emerging and re-emerging viral diseases are of great public health concern. The recent emergence of Severe Acute Respiratory Syndrome (SARS) related coronavirus (SARS-CoV-2) in December 2019 in China, which causes COVID-19 disease in humans, and its current spread to several countries, leading to the first pandemic in history to be caused by a coronavirus, highlights the significance of zoonotic viral diseases. Rift Valley fever, rabies, West Nile, chikungunya, dengue, yellow fever, Crimean-Congo hemorrhagic fever, Ebola, and influenza viruses among many other viruses have been reported from different African countries. The paucity of information, lack of knowledge, limited resources, and climate change, coupled with cultural traditions make the African continent a hotspot for vector-borne and zoonotic viral diseases, which may spread globally. Currently, there is no information available on the status of virus diseases in Africa. This systematic review highlights the available information about viral diseases, including zoonotic and vector-borne diseases, reported in Africa. The findings will help us understand the trend of emerging and re-emerging virus diseases within the African continent. The findings recommend active surveillance of viral diseases and strict implementation of One Health measures in Africa to improve human public health and reduce the possibility of potential pandemics due to zoonotic viruses.", "doi": "10.3390/pathogens9040301", "pmid": "32325980", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "pathogens9040301"}, {"db": "pmc", "key": "PMC7238228"}], "notes": [], "created": "2020-11-19T14:19:08.521Z", "modified": "2021-12-06T12:56:28.620Z"}, {"entity": "publication", "iuid": "e0e3251f02a949849818c8647d613c7a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/e0e3251f02a949849818c8647d613c7a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/e0e3251f02a949849818c8647d613c7a"}}, "title": "Essential care of critical illness must not be forgotten in the COVID-19 pandemic.", "authors": [{"family": "Baker", "given": "Tim", "initials": "T"}, {"family": "Schell", "given": "Carl Otto", "initials": "CO"}, {"family": "Petersen", "given": "Dan Brun", "initials": "DB"}, {"family": "Sawe", "given": "Hendry", "initials": "H"}, {"family": "Khalid", "given": "Karima", "initials": "K"}, {"family": "Mndolo", "given": "Samson", "initials": "S"}, {"family": "Rylance", "given": "Jamie", "initials": "J"}, {"family": "McAuley", "given": "Daniel F", "initials": "DF"}, {"family": "Roy", "given": "Nobhojit", "initials": "N"}, {"family": "Marshall", "given": "John", "initials": "J"}, {"family": "Wallis", "given": "Lee", "initials": "L"}, {"family": "Molyneux", "given": "Elizabeth", "initials": "E"}], "type": "letter", "published": "2020-04-18", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "395", "issue": "10232", "pages": "1253-1254", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)30793-5", "pmid": "32246914", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)30793-5"}, {"db": "pmc", "key": "PMC7270584"}], "notes": [], "created": "2020-11-19T14:16:58.470Z", "modified": "2020-12-09T11:48:50.291Z"}, {"entity": "publication", "iuid": "111c43323baa4cdf84eeecd9a2dc7af9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/111c43323baa4cdf84eeecd9a2dc7af9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/111c43323baa4cdf84eeecd9a2dc7af9"}}, "title": "Steroid-responsive encephalitis in Covid-19 disease", "authors": [{"family": "Pilotto", "given": "Andrea", "initials": "A", "orcid": "0000-0003-2029-6606", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/221835a6e81a4a4eb7e302df55681c23.json"}}, {"family": "Odolini", "given": "Silvia", "initials": "S"}, {"family": "Masciocchi S", "given": "Stefano", "initials": "S"}, {"family": "Comelli", "given": "Agnese", "initials": "A"}, {"family": "Volonghi", "given": "Irene", "initials": "I"}, {"family": "Gazzina", "given": "Stefano", "initials": "S"}, {"family": "Nocivelli", "given": "Sara", "initials": "S"}, {"family": "Pezzini", "given": "Alessandro", "initials": "A"}, {"family": "Foc\u00e0", "given": "Emanuele", "initials": "E"}, {"family": "Caruso", "given": "Arnaldo", "initials": "A"}, {"family": "Leonardi", "given": "Matilde", "initials": "M"}, {"family": "Pasolini", "given": "Maria Pia", "initials": "MP"}, {"family": "Gasparotti R", "given": "Roberto", "initials": "R"}, {"family": "Castelli F", "given": "Francesco", "initials": "F"}, {"family": "Ashton", "given": "Nicholas J", "initials": "NJ"}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Padovani", "given": "Alessandro", "initials": "A"}], "type": "posted-content", "published": "2020-04-17", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.04.12.20062646", "pmid": null, "labels": {"Category: Biochemistry": null, "Type: Preprint": null, "Category: Health": null, "Category: Drug Discovery": null}, "xrefs": [], "notes": [], "created": "2021-06-17T07:56:31.458Z", "modified": "2022-11-22T05:52:11.424Z"}, {"entity": "publication", "iuid": "f3f7011473894c83b2e34fa2ea6980ae", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f3f7011473894c83b2e34fa2ea6980ae.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f3f7011473894c83b2e34fa2ea6980ae"}}, "title": "ACE2 and coronavirus - a question of balance and dynamics?", "authors": [{"family": "Lundstr\u00f6m", "given": "Annika", "initials": "A"}, {"family": "Sand\u00e9n", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2020-04-17", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": "The new SARS-CoV-2 virus enters cells via angiotensin-converting enzyme 2 (ACE2). ACE2 counteracts ACE and angiotensin II in the renin-angiotensin-aldosterone system (RAAS) and has critical functions in the lung and cardiovascular system. SARS-CoV was found to down-regulate ACE2, leaving angiotensin II unbalanced in affected organs. A similar effect of SARS-CoV-2 could partly explain risk factors and symptoms, and could potentially be treatable.", "doi": null, "pmid": "32314329", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "F3S3"}], "notes": [], "created": "2020-11-23T11:42:16.237Z", "modified": "2020-12-08T07:17:55.750Z"}, {"entity": "publication", "iuid": "8ff1da243d924635a0a9dbf4d20e1dce", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8ff1da243d924635a0a9dbf4d20e1dce.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8ff1da243d924635a0a9dbf4d20e1dce"}}, "title": "COVID-19 and Working Conditions in Health Care.", "authors": [{"family": "Theorell", "given": "T\u00f6res", "initials": "T"}], "type": "editorial", "published": "2020-04-16", "journal": {"title": "Psychother Psychosom", "issn": "1423-0348", "volume": "89", "issue": "4", "pages": "193-194", "issn-l": "0033-3190"}, "abstract": "Editorial", "doi": "10.1159/000507765", "pmid": "32299083", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "000507765"}, {"db": "pmc", "key": "PMC7206352"}], "notes": [], "created": "2020-11-23T11:30:26.354Z", "modified": "2020-12-09T14:49:06.411Z"}, {"entity": "publication", "iuid": "f7a80019e75845f4968677a6d71180bf", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f7a80019e75845f4968677a6d71180bf.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f7a80019e75845f4968677a6d71180bf"}}, "title": "Intervention strategies against COVID-19 and their estimated impact on Swedish healthcare capacity", "authors": [{"family": "Gardner", "given": "Jasmine M", "initials": "JM", "orcid": "0000-0002-6399-8504", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/142f79739167491c9024e0fb17187f2f.json"}}, {"family": "Willem", "given": "Lander", "initials": "L", "orcid": "0000-0002-9210-1196", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/485594f08c334c55bcf8b1159db1befc.json"}}, {"family": "Van Der Wijngaart", "given": "Wouter", "initials": "W", "orcid": "0000-0001-8248-6670", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/08189699080c43df85b527923d969525.json"}}, {"family": "Kamerlin", "given": "Shina Caroline Lynn", "initials": "SCL", "orcid": "0000-0002-3190-1173", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/ce94c3055e2b4f50b0ff4c16eac65658.json"}}, {"family": "Brusselaers", "given": "Nele", "initials": "N", "orcid": "0000-0003-0137-447X", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/e8a4e9c84a5843c18e95fe0becb19506.json"}}, {"family": "Kasson", "given": "Peter", "initials": "P", "orcid": "0000-0002-3111-8103", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/aa48f188557f4339bbe05fa87f336b37.json"}}], "type": "posted-content", "published": "2020-04-15", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.04.11.20062133", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null}, "xrefs": [], "notes": [], "created": "2021-06-17T08:36:28.175Z", "modified": "2022-11-22T05:52:03.951Z"}, {"entity": "publication", "iuid": "09ace0cf9b2b48a8b3235cd5c546314b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/09ace0cf9b2b48a8b3235cd5c546314b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/09ace0cf9b2b48a8b3235cd5c546314b"}}, "title": "Editorial: Covid-19 and Physical and Rehabilitation Medicine.", "authors": [{"family": "Borg", "given": "Kristian", "initials": "K"}, {"family": "Stam", "given": "Henk", "initials": "H"}], "type": "editorial", "published": "2020-04-15", "journal": {"title": "J Rehabil Med", "issn": "1651-2081", "volume": "52", "issue": "4", "pages": "jrm00045", "issn-l": null}, "abstract": null, "doi": "10.2340/16501977-2679", "pmid": "32286673", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-12-09T12:06:38.361Z", "modified": "2020-12-09T12:06:38.383Z"}, {"entity": "publication", "iuid": "f5023749413543a6bf5155fed22df06c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f5023749413543a6bf5155fed22df06c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f5023749413543a6bf5155fed22df06c"}}, "title": "Pediatric Endocrinology in the Time of the COVID-19 Pandemic.", "authors": [{"family": "Cianfarani", "given": "Stefano", "initials": "S"}], "type": "editorial", "published": "2020-04-09", "journal": {"title": "Horm Res Paediatr", "issn": "1663-2826", "volume": "92", "issue": "6", "pages": "345-346", "issn-l": "1663-2818"}, "abstract": "Editorial", "doi": "10.1159/000507703", "pmid": "32272473", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "000507703"}, {"db": "pmc", "key": "PMC7206355"}], "notes": [], "created": "2020-11-23T11:36:15.264Z", "modified": "2020-12-09T12:04:34.240Z"}, {"entity": "publication", "iuid": "9b929466d23449f79a9fc7631737267f", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9b929466d23449f79a9fc7631737267f.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9b929466d23449f79a9fc7631737267f"}}, "title": "F\u00f6rlorat luktsinne \u2013 m\u00f6jligt tidigt tecken p\u00e5 covid-19", "authors": [{"family": "N Lundstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Stj\u00e4rne", "given": "P\u00e4r", "initials": "P"}], "type": "journal article", "published": "2020-04-08", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "volume": "117", "issue": null, "pages": null, "issn-l": "0023-7205"}, "abstract": "Comment", "doi": null, "pmid": "32293016", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "F3P9"}], "notes": [], "created": "2020-11-23T11:29:43.793Z", "modified": "2021-12-06T12:51:58.143Z"}, {"entity": "publication", "iuid": "56b0c4045cd34bcfa299c09a7806480b", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/56b0c4045cd34bcfa299c09a7806480b.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/56b0c4045cd34bcfa299c09a7806480b"}}, "title": "Only strict quarantine measures can curb the coronavirus disease (COVID-19) outbreak in Italy, 2020", "authors": [{"family": "Sj\u00f6din", "given": "Henrik", "initials": "H"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Osman", "given": "Sarah", "initials": "S"}, {"family": "Farooq", "given": "Zia", "initials": "Z"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}], "type": "journal-article", "published": "2020-04-02", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "13", "issn-l": null}, "abstract": "Several Italian towns are under lockdown to contain the COVID-19 outbreak. The level of transmission reduction required for physical distancing interventions to mitigate the epidemic is a crucial question. We show that very high adherence to community quarantine (total stay-home policy) and a small household size is necessary for curbing the outbreak in a locked-down town. The larger the household size and amount of time in the public, the longer the lockdown period needed.", "doi": "10.2807/1560-7917.es.2020.25.13.2000280", "pmid": "32265005", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7140595"}], "notes": [], "created": "2020-12-09T12:02:19.916Z", "modified": "2021-12-06T12:50:36.128Z"}, {"entity": "publication", "iuid": "843a79f658174ae8bd88e64050cf7fc9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/843a79f658174ae8bd88e64050cf7fc9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/843a79f658174ae8bd88e64050cf7fc9"}}, "title": "COVID-19: GENERAL GUIDELINES FOR CARDIOVASCULAR SURGEONS (standard guidelines - subject to change).", "authors": [{"family": "Barros", "given": "Leila", "initials": "L"}, {"family": "Rivetti", "given": "Luiz Ant\u00f4nio", "initials": "LA"}, {"family": "Furlanetto", "given": "Beatriz Helena", "initials": "BH"}, {"family": "Teixeira", "given": "Eduardo Miranda", "initials": "EM"}, {"family": "Welikow", "given": "Alexandre", "initials": "A"}], "type": "editorial", "published": "2020-04-01", "journal": {"title": "Braz J Cardiovasc Surg", "issn": "1678-9741", "volume": "35", "issue": "2", "pages": "I-III", "issn-l": null}, "abstract": null, "doi": "10.21470/1678-9741-1-2020-0604", "pmid": "32369287", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7199979"}], "notes": [], "created": "2020-12-10T07:29:07.890Z", "modified": "2020-12-10T07:29:07.913Z"}, {"entity": "publication", "iuid": "377dff7d7d5d47d1861a22cd559bfac5", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/377dff7d7d5d47d1861a22cd559bfac5.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/377dff7d7d5d47d1861a22cd559bfac5"}}, "title": "The Current Clinically Relevant Findings on COVID-19 Pandemic.", "authors": [{"family": "Pergolizzi", "given": "Joseph V", "initials": "JV"}, {"family": "Magnusson", "given": "Peter", "initials": "P"}, {"family": "LeQuang", "given": "Jo Ann", "initials": "JA"}, {"family": "Breve", "given": "Frank", "initials": "F"}, {"family": "Paladini", "given": "Antonella", "initials": "A"}, {"family": "Rekatsina", "given": "Martina", "initials": "M"}, {"family": "Yeam", "given": "Cheng Teng", "initials": "CT"}, {"family": "Imani", "given": "Farnad", "initials": "F"}, {"family": "Saltelli", "given": "Giorgia", "initials": "G"}, {"family": "Taylor", "given": "Robert", "initials": "R"}, {"family": "Wollmuth", "given": "Charles", "initials": "C"}, {"family": "Varrassi", "given": "Giustino", "initials": "G"}], "type": "journal article", "published": "2020-04-00", "journal": {"title": "Anesth Pain Med", "issn": "2228-7523", "volume": "10", "issue": "2", "pages": "e103819", "issn-l": null}, "abstract": "The emergence of a novel coronavirus and coronavirus disease 2019 (COVID-19) represents a challenge to global healthcare. In the past 20 years, this is the third coronavirus that jumped the species barrier and infected humans. It is highly contagious but associated with low pathogenicity. First identified in Wuhan, China, a city of over 11 million, the disease has since spread to every continent except Antarctica. About 15% to 20% of all cases may be called severe, and it is believed many cases are asymptomatic. The average age of a person with COVID has been reported as 49 years. Worse outcomes are associated with geriatric populations and those with underlying diseases such as cardiovascular, respiratory disorders, and/or diabetes. The coronavirus, like other coronaviruses, is highly contagious and has a latency period of about 14 days. Most patients present with fever and a dry cough, but fever may be absent. Differential diagnosis can be challenging since influenza may present with similar symptoms. Chest radiography or computed tomography may be used to find evidence of secondary pneumonia. Nosocomial infection is of concern, and it has been reported that 3.8% of all cases with COVID-19 in that country involve healthcare workers in China. Most patients have mild disease, and supportive care suffices. A variety of repurposed and investigational drugs are being evaluated. There are currently no antiviral therapies or vaccines, even if many therapies are proposed. Hand hygiene, social distancing, and scientifically sound information are the best strategies at the moment to combat this epidemic.", "doi": "10.5812/aapm.103819", "pmid": "32754437", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7352949"}], "notes": [], "created": "2020-11-26T12:19:57.995Z", "modified": "2020-11-30T08:42:57.911Z"}, {"entity": "publication", "iuid": "39912591ca454520996acbfbd8dba3e6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/39912591ca454520996acbfbd8dba3e6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/39912591ca454520996acbfbd8dba3e6"}}, "title": "The COVID-19 pandemic: The \u2018black swan\u2019 for mental health care and a turning point for e-health", "authors": [{"family": "Wind", "given": "Tim R", "initials": "TR"}, {"family": "Rijkeboer", "given": "Marleen", "initials": "M"}, {"family": "Andersson", "given": "Gerhard", "initials": "G"}, {"family": "Riper", "given": "Heleen", "initials": "H"}], "type": "journal-article", "published": "2020-04-00", "journal": {"title": "Internet Interv", "issn": "2214-7829", "volume": "20", "issue": null, "pages": "100317", "issn-l": "2214-7829"}, "abstract": "Editorial", "doi": "10.1016/j.invent.2020.100317", "pmid": "32289019", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S2214-7829(20)30046-4"}, {"db": "pii", "key": "100317"}, {"db": "pmc", "key": "PMC7104190"}], "notes": [], "created": "2020-11-25T07:15:05.334Z", "modified": "2021-12-06T12:50:54.330Z"}, {"entity": "publication", "iuid": "a285403dbfaf42e893ce70fc3cd5bbde", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/a285403dbfaf42e893ce70fc3cd5bbde.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/a285403dbfaf42e893ce70fc3cd5bbde"}}, "title": "Novel corona virus disease (COVID\u201019) in pregnancy: What clinical recommendations to follow?", "authors": [{"family": "Liang", "given": "Huan", "initials": "H"}, {"family": "Acharya", "given": "Ganesh", "initials": "G", "orcid": "0000-0002-1997-3107", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/1d1c2ac0dfb849d8b2374451e38cdcba.json"}}], "type": "journal-article", "published": "2020-04-00", "journal": {"title": "Acta Obstet Gynecol Scand", "issn": "0001-6349", "volume": "99", "issue": "4", "pages": "439-442", "issn-l": null}, "abstract": "Editorial", "doi": "10.1111/aogs.13836", "pmid": "32141062", "labels": {"Type: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-22T16:58:43.722Z", "modified": "2021-12-06T12:50:02.730Z"}, {"entity": "publication", "iuid": "8760bdfa78534e329ab14882337e1681", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8760bdfa78534e329ab14882337e1681.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8760bdfa78534e329ab14882337e1681"}}, "title": "Harnessing the immune system via Fc\u03b3R function in immune therapy: a pathway to next\u2010gen mAbs", "authors": [{"family": "Chenoweth", "given": "Alicia M", "initials": "AM"}, {"family": "Wines", "given": "Bruce D", "initials": "BD"}, {"family": "Anania", "given": "Jessica C", "initials": "JC"}, {"family": "Mark Hogarth", "given": "P", "initials": "P"}], "type": "journal-article", "published": "2020-04-00", "journal": {"title": "Immunol Cell Biol", "issn": "0818-9641", "volume": "98", "issue": "4", "pages": "287-304", "issn-l": null}, "abstract": "The human fragment crystallizable (Fc)\u03b3 receptor (R) interacts with antigen-complexed immunoglobulin (Ig)G ligands to both activate and modulate a powerful network of inflammatory host-protective effector functions that are key to the normal physiology of immune resistance to pathogens. More than 100 therapeutic monoclonal antibodies (mAbs) are approved or in late stage clinical trials, many of which harness the potent Fc\u03b3R-mediated effector systems to varying degrees. This is most evident for antibodies targeting cancer cells inducing antibody-dependent killing or phagocytosis but is also true to some degree for the mAbs that neutralize or remove small macromolecules such as cytokines or other Igs. The use of mAb therapeutics has also revealed a \"scaffolding\" role for Fc\u03b3R which, in different contexts, may either underpin the therapeutic mAb action such as immune agonism or trigger catastrophic adverse effects. The still unmet therapeutic need in many cancers, inflammatory diseases or emerging infections such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires increased effort on the development of improved and novel mAbs. A more mature appreciation of the immunobiology of individual Fc\u03b3R function and the complexity of the relationships between Fc\u03b3Rs and antibodies is fueling efforts to develop more potent \"next-gen\" therapeutic antibodies. Such development strategies now include focused glycan or protein engineering of the Fc to increase affinity and/or tailor specificity for selective engagement of individual activating Fc\u03b3Rs or the inhibitory Fc\u03b3RIIb or alternatively, for the ablation of Fc\u03b3R interaction altogether. This review touches on recent aspects of Fc\u03b3R and IgG immunobiology and its relationship with the present and future actions of therapeutic mAbs.", "doi": "10.1111/imcb.12326", "pmid": "32157732", "labels": {"Type: Review": null}, "xrefs": [{"db": "pmc", "key": "PMC7228307"}], "notes": [], "created": "2020-11-22T09:23:12.446Z", "modified": "2021-12-06T12:49:37.522Z"}, {"entity": "publication", "iuid": "0468f23a15f441f5b13ce8e44305625a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/0468f23a15f441f5b13ce8e44305625a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/0468f23a15f441f5b13ce8e44305625a"}}, "title": "A hundred days into the coronavirus disease (COVID-19) pandemic.", "authors": [{"family": "Steffens", "given": "Ines", "initials": "I"}], "type": "editorial", "published": "2020-04-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "14", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.14.2000550", "pmid": "32290905", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7160442"}], "notes": [], "created": "2020-12-09T12:07:21.950Z", "modified": "2021-12-06T12:49:10.360Z"}, {"entity": "publication", "iuid": "924a0d531a614d58a8ed52f344fb1932", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/924a0d531a614d58a8ed52f344fb1932.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/924a0d531a614d58a8ed52f344fb1932"}}, "title": "Novel Coronavirus Infection (COVID-19) in Humans: A Scoping Review and Meta-Analysis.", "authors": [{"family": "Borges do Nascimento", "given": "Israel J\u00fanior", "initials": "IJ"}, {"family": "Cacic", "given": "Nensi", "initials": "N"}, {"family": "Abdulazeem", "given": "Hebatullah Mohamed", "initials": "HM"}, {"family": "von Groote", "given": "Thilo Caspar", "initials": "TC"}, {"family": "Jayarajah", "given": "Umesh", "initials": "U"}, {"family": "Weerasekara", "given": "Ishanka", "initials": "I"}, {"family": "Esfahani", "given": "Meisam Abdar", "initials": "MA"}, {"family": "Civile", "given": "Vinicius Tassoni", "initials": "VT"}, {"family": "Marusic", "given": "Ana", "initials": "A"}, {"family": "Jeroncic", "given": "Ana", "initials": "A"}, {"family": "Carvas Junior", "given": "Nelson", "initials": "N"}, {"family": "Pericic", "given": "Tina Poklepovic", "initials": "TP"}, {"family": "Zakarija-Grkovic", "given": "Irena", "initials": "I"}, {"family": "Meirelles Guimar\u00e3es", "given": "Silvana Mangeon", "initials": "SM"}, {"family": "Luigi Bragazzi", "given": "Nicola", "initials": "N"}, {"family": "Bjorklund", "given": "Maria", "initials": "M"}, {"family": "Sofi-Mahmudi", "given": "Ahmad", "initials": "A"}, {"family": "Altujjar", "given": "Mohammad", "initials": "M"}, {"family": "Tian", "given": "Maoyi", "initials": "M"}, {"family": "Arcani", "given": "Diana Maria Cespedes", "initials": "DMC"}, {"family": "O'Math\u00fana", "given": "D\u00f3nal P", "initials": "DP"}, {"family": "Marcolino", "given": "Milena Soriano", "initials": "MS"}], "type": "journal article", "published": "2020-03-30", "journal": {"title": "J Clin Med", "issn": "2077-0383", "volume": "9", "issue": "4", "issn-l": "2077-0383"}, "abstract": "A growing body of literature on the 2019 novel coronavirus (SARS-CoV-2) is becoming available, but a synthesis of available data has not been conducted. We performed a scoping review of currently available clinical, epidemiological, laboratory, and chest imaging data related to the SARS-CoV-2 infection. We searched MEDLINE, Cochrane CENTRAL, EMBASE, Scopus and LILACS from 01 January 2019 to 24 February 2020. Study selection, data extraction and risk of bias assessment were performed by two independent reviewers. Qualitative synthesis and meta-analysis were conducted using the clinical and laboratory data, and random-effects models were applied to estimate pooled results. A total of 61 studies were included (59,254 patients). The most common disease-related symptoms were fever (82%, 95% confidence interval (CI) 56%-99%; n = 4410), cough (61%, 95% CI 39%-81%; n = 3985), muscle aches and/or fatigue (36%, 95% CI 18%-55%; n = 3778), dyspnea (26%, 95% CI 12%-41%; n = 3700), headache in 12% (95% CI 4%-23%, n = 3598 patients), sore throat in 10% (95% CI 5%-17%, n = 1387) and gastrointestinal symptoms in 9% (95% CI 3%-17%, n = 1744). Laboratory findings were described in a lower number of patients and revealed lymphopenia (0.93 \u00d7 109/L, 95% CI 0.83-1.03 \u00d7 109/L, n = 464) and abnormal C-reactive protein (33.72 mg/dL, 95% CI 21.54-45.91 mg/dL; n = 1637). Radiological findings varied, but mostly described ground-glass opacities and consolidation. Data on treatment options were limited. All-cause mortality was 0.3% (95% CI 0.0%-1.0%; n = 53,631). Epidemiological studies showed that mortality was higher in males and elderly patients. The majority of reported clinical symptoms and laboratory findings related to SARS-CoV-2 infection are non-specific. Clinical suspicion, accompanied by a relevant epidemiological history, should be followed by early imaging and virological assay.", "doi": "10.3390/jcm9040941", "pmid": "32235486", "labels": {"Type: Review": null}, "xrefs": [{"db": "pii", "key": "jcm9040941"}, {"db": "pmc", "key": "PMC7230636"}], "notes": [], "created": "2020-11-30T16:01:46.945Z", "modified": "2020-12-09T11:48:12.765Z"}, {"entity": "publication", "iuid": "b9110c7439e54c1a983a6e0fbc7748c9", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/b9110c7439e54c1a983a6e0fbc7748c9.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/b9110c7439e54c1a983a6e0fbc7748c9"}}, "title": "COVID-19: towards controlling of a pandemic.", "authors": [{"family": "Bedford", "given": "Juliet", "initials": "J"}, {"family": "Enria", "given": "Delia", "initials": "D"}, {"family": "Giesecke", "given": "Johan", "initials": "J"}, {"family": "Heymann", "given": "David L", "initials": "DL"}, {"family": "Ihekweazu", "given": "Chikwe", "initials": "C"}, {"family": "Kobinger", "given": "Gary", "initials": "G"}, {"family": "Lane", "given": "H Clifford", "initials": "HC"}, {"family": "Memish", "given": "Ziad", "initials": "Z"}, {"family": "Oh", "given": "Myoung-Don", "initials": "MD"}, {"family": "Sall", "given": "Amadou Alpha", "initials": "AA"}, {"family": "Schuchat", "given": "Anne", "initials": "A"}, {"family": "Ungchusak", "given": "Kumnuan", "initials": "K"}, {"family": "Wieler", "given": "Lothar H", "initials": "LH"}, {"family": "WHO Strategic and Technical Advisory Group for Infectious Hazards", "given": "", "initials": ""}], "type": "journal article", "published": "2020-03-28", "journal": {"title": "Lancet", "issn": "1474-547X", "volume": "395", "issue": "10229", "pages": "1015-1018", "issn-l": "0140-6736"}, "abstract": null, "doi": "10.1016/S0140-6736(20)30673-5", "pmid": "32197103", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0140-6736(20)30673-5"}, {"db": "pmc", "key": "PMC7270596"}], "notes": [], "created": "2020-11-22T17:02:19.626Z", "modified": "2020-12-10T09:04:01.272Z"}, {"entity": "publication", "iuid": "551696f1ed29428c891af663c479317e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/551696f1ed29428c891af663c479317e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/551696f1ed29428c891af663c479317e"}}, "title": "The Fear of COVID-19 Scale: Development and Initial Validation.", "authors": [{"family": "Ahorsu", "given": "Daniel Kwasi", "initials": "DK"}, {"family": "Lin", "given": "Chung-Ying", "initials": "C"}, {"family": "Imani", "given": "Vida", "initials": "V"}, {"family": "Saffari", "given": "Mohsen", "initials": "M"}, {"family": "Griffiths", "given": "Mark D", "initials": "MD"}, {"family": "Pakpour", "given": "Amir H", "initials": "AH"}], "type": "case reports", "published": "2020-03-27", "journal": {"title": "Int J Ment Health Addict", "issn": "1557-1874", "issn-l": null, "volume": null, "issue": null, "pages": "1-9"}, "abstract": "The emergence of the COVID-19 and its consequences has led to fears, worries, and anxiety among individuals worldwide. The present study developed the Fear of COVID-19 Scale (FCV-19S) to complement the clinical efforts in preventing the spread and treating of COVID-19 cases.\r\n\r\nThe sample comprised 717 Iranian participants. The items of the FCV-19S were constructed based on extensive review of existing scales on fears, expert evaluations, and participant interviews. Several psychometric tests were conducted to ascertain its reliability and validity properties.\r\n\r\nAfter panel review and corrected item-total correlation testing, seven items with acceptable corrected item-total correlation (0.47 to 0.56) were retained and further confirmed by significant and strong factor loadings (0.66 to 0.74). Also, other properties evaluated using both classical test theory and Rasch model were satisfactory on the seven-item scale. More specifically, reliability values such as internal consistency ( \u03b1 = .82) and test-retest reliability (ICC = .72) were acceptable. Concurrent validity was supported by the Hospital Anxiety and Depression Scale (with depression, r = 0.425 and anxiety, r = 0.511) and the Perceived Vulnerability to Disease Scale (with perceived infectability, r = 0.483 and germ aversion, r = 0.459).\r\n\r\nThe Fear of COVID-19 Scale, a seven-item scale, has robust psychometric properties. It is reliable and valid in assessing fear of COVID-19 among the general population and will also be useful in allaying COVID-19 fears among individuals.", "doi": "10.1007/s11469-020-00270-8", "pmid": "32226353", "labels": {"Type: Journal article": null, "Category: Social Science & Humanities": null}, "xrefs": [{"db": "pii", "key": "270"}, {"db": "pmc", "key": "PMC7100496"}], "notes": [], "created": "2020-11-30T16:01:48.181Z", "modified": "2022-11-10T07:58:14.325Z"}, {"entity": "publication", "iuid": "c6ab29c6e3564897a13b3610d928cca6", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/c6ab29c6e3564897a13b3610d928cca6.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/c6ab29c6e3564897a13b3610d928cca6"}}, "title": "Combating COVID-19-The role of robotics in managing public health and infectious diseases.", "authors": [{"family": "Yang", "given": "Guang-Zhong", "initials": "GZ"}, {"family": "J Nelson", "given": "Bradley", "initials": "B"}, {"family": "Murphy", "given": "Robin R", "initials": "RR"}, {"family": "Choset", "given": "Howie", "initials": "H"}, {"family": "Christensen", "given": "Henrik", "initials": "H"}, {"family": "H Collins", "given": "Steven", "initials": "S"}, {"family": "Dario", "given": "Paolo", "initials": "P"}, {"family": "Goldberg", "given": "Ken", "initials": "K"}, {"family": "Ikuta", "given": "Koji", "initials": "K"}, {"family": "Jacobstein", "given": "Neil", "initials": "N"}, {"family": "Kragic", "given": "Danica", "initials": "D"}, {"family": "Taylor", "given": "Russell H", "initials": "RH"}, {"family": "McNutt", "given": "Marcia", "initials": "M"}], "type": "editorial", "published": "2020-03-25", "journal": {"title": "Sci Robot", "issn": "2470-9476", "volume": "5", "issue": "40", "issn-l": null}, "abstract": "COVID-19 may drive sustained research in robotics to address risks of infectious diseases.", "doi": "10.1126/scirobotics.abb5589", "pmid": "33022599", "labels": {"Type: Journal article": null}, "xrefs": [{"db": "pii", "key": "5/40/eabb5589"}], "notes": [], "created": "2020-12-01T18:16:32.224Z", "modified": "2020-12-01T18:16:32.248Z"}, {"entity": "publication", "iuid": "4dbadc63c07b41d4b20a9a1492bba241", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4dbadc63c07b41d4b20a9a1492bba241.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4dbadc63c07b41d4b20a9a1492bba241"}}, "title": "Hypertension and Diabetes Delay the Viral Clearance in COVID-19 Patients", "authors": [{"family": "Chen", "given": "Xiaoping", "initials": "X"}, {"family": "Hu", "given": "Wenjia", "initials": "W"}, {"family": "Ling", "given": "Jiaxin", "initials": "J"}, {"family": "Mo", "given": "Pingzheng", "initials": "P"}, {"family": "Zhang", "given": "Yongxi", "initials": "Y"}, {"family": "Jiang", "given": "Qunqun", "initials": "Q"}, {"family": "Ma", "given": "Zhiyong", "initials": "Z"}, {"family": "Cao", "given": "Qian", "initials": "Q"}, {"family": "Deng", "given": "Liping", "initials": "L"}, {"family": "Song", "given": "Shihui", "initials": "S"}, {"family": "Zheng", "given": "Ruiying", "initials": "R"}, {"family": "Gao", "given": "Shicheng", "initials": "S"}, {"family": "Ke", "given": "Hengning", "initials": "H"}, {"family": "Gui", "given": "Xien", "initials": "X"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Li", "given": "Jinlin", "initials": "J"}, {"family": "Lindahl", "given": "Johanna F", "initials": "JF"}, {"family": "Xiong", "given": "Yong", "initials": "Y"}], "type": "posted-content", "published": "2020-03-24", "journal": {"title": null, "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2020.03.22.20040774", "pmid": null, "labels": {"Type: Preprint": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-17T08:39:04.505Z", "modified": "2023-06-19T15:38:10.655Z"}, {"entity": "publication", "iuid": "5156c5f3e35b41e8b789fbc7915c044c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/5156c5f3e35b41e8b789fbc7915c044c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/5156c5f3e35b41e8b789fbc7915c044c"}}, "title": "Covid-19 \u2013 uppdatering om klinisk bild och behandling", "authors": [{"family": "Glans", "given": "Hedvig", "initials": "H"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Aleman", "given": "Soo", "initials": "S"}], "type": "journal article", "published": "2020-03-23", "journal": {"title": "Lakartidningen", "issn": "1652-7518", "issn-l": "0023-7205", "volume": "117", "issue": null, "pages": null}, "abstract": null, "doi": null, "pmid": "32266709", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pii", "key": "F3HW"}], "notes": [], "created": "2020-11-22T17:09:54.906Z", "modified": "2021-02-26T08:45:48.147Z"}, {"entity": "publication", "iuid": "82ccc1b68ddb4510ae5faf4cd89ac89e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/82ccc1b68ddb4510ae5faf4cd89ac89e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/82ccc1b68ddb4510ae5faf4cd89ac89e"}}, "title": "COVID-19 healthcare demand and mortality in Sweden in response to non-pharmaceutical (NPIs) mitigation and suppression scenarios", "authors": [{"family": "Sj\u00f6din", "given": "Henrik", "initials": "H"}, {"family": "Johansson", "given": "Anders F", "initials": "AF"}, {"family": "Br\u00e4nnstr\u00f6m", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Farooq", "given": "Zia", "initials": "Z"}, {"family": "Kriit", "given": "Hedi Katre", "initials": "HK"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "\u00c5str\u00f6m", "given": "Christofer", "initials": "C"}, {"family": "Thunberg", "given": "Johan", "initials": "J"}, {"family": "S\u00f6derquist", "given": "M\u00e5rten", "initials": "M"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}], "type": "posted-content", "published": "2020-03-23", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.03.20.20039594", "pmid": null, "labels": {"Type: Preprint": null, "Category: Public Health": null, "Category: Health": null}, "xrefs": [], "notes": [], "created": "2021-06-14T06:39:24.677Z", "modified": "2022-11-22T05:51:45.396Z"}, {"entity": "publication", "iuid": "130e2061ba1041cc976a4b994ce63471", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/130e2061ba1041cc976a4b994ce63471.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/130e2061ba1041cc976a4b994ce63471"}}, "title": "The reproductive number of COVID-19 is higher compared to SARS coronavirus.", "authors": [{"family": "Liu", "given": "Ying", "initials": "Y"}, {"family": "Gayle", "given": "Albert A", "initials": "AA"}, {"family": "Wilder-Smith", "given": "Annelies", "initials": "A"}, {"family": "Rockl\u00f6v", "given": "Joacim", "initials": "J"}], "type": "journal article", "published": "2020-03-13", "journal": {"title": "J Travel Med", "issn": "1708-8305", "issn-l": null, "volume": "27", "issue": "2", "pages": null}, "abstract": null, "doi": "10.1093/jtm/taaa021", "pmid": "32052846", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "5735319"}, {"db": "pmc", "key": "PMC7074654"}], "notes": [], "created": "2020-11-30T16:01:53.074Z", "modified": "2020-12-11T14:18:52.131Z"}, {"entity": "publication", "iuid": "2e73a2c38f314f2ca50f2e333abb227c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2e73a2c38f314f2ca50f2e333abb227c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2e73a2c38f314f2ca50f2e333abb227c"}}, "title": "Potential impact of seasonal forcing on a SARS-CoV-2 pandemic.", "authors": [{"family": "Neher", "given": "Richard A", "initials": "RA"}, {"family": "Dyrdak", "given": "Robert", "initials": "R", "orcid": "0000-0001-8456-4898", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/98ad76a0e144478cb3ceabd05c9928b0.json"}}, {"family": "Druelle", "given": "Valentin", "initials": "V"}, {"family": "Hodcroft", "given": "Emma B", "initials": "EB"}, {"family": "Albert", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2020-03-09", "journal": {"title": "Swiss Med Wkly", "issn": "1424-3997", "issn-l": "0036-7672", "volume": "150", "issue": null, "pages": "w20224"}, "abstract": "A novel coronavirus (SARS-CoV-2) first detected in Wuhan, China, has spread rapidly since December 2019, causing more than 100,000 confirmed infections and 4000 fatalities (as of 10 March 2020). The outbreak has been declared a pandemic by the WHO on Mar 11, 2020. Here, we explore how seasonal variation in transmissibility could modulate a SARS-CoV-2 pandemic. Data from routine diagnostics show a strong and consistent seasonal variation of the four endemic coronaviruses (229E, HKU1, NL63, OC43) and we parameterise our model for SARS-CoV-2 using these data. The model allows for many subpopulations of different size with variable parameters. Simulations of different scenarios show that plausible parameters result in a small peak in early 2020 in temperate regions of the Northern Hemisphere and a larger peak in winter 2020/2021. Variation in transmission and migration rates can result in substantial variation in prevalence between regions. While the uncertainty in parameters is large, the scenarios we explore show that transient reductions in the incidence rate might be due to a combination of seasonal variation and infection control efforts but do not necessarily mean the epidemic is contained. Seasonal forcing on SARS-CoV-2 should thus be taken into account in the further monitoring of the global transmission. The likely aggregated effect of seasonal variation, infection control measures, and transmission rate variation is a prolonged pandemic wave with lower prevalence at any given time, thereby providing a window of opportunity for better preparation of health care systems.", "doi": "10.4414/smw.2020.20224", "pmid": "32176808", "labels": {"Type: Journal article": null, "Category: Other": null}, "xrefs": [{"db": "pii", "key": "Swiss Med Wkly. 2020;150:w20224"}], "notes": [], "created": "2020-11-17T17:38:57.263Z", "modified": "2023-06-19T14:45:01.419Z"}, {"entity": "publication", "iuid": "f4cd5fc5b81b412089e6ad0921ece7a0", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/f4cd5fc5b81b412089e6ad0921ece7a0.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/f4cd5fc5b81b412089e6ad0921ece7a0"}}, "title": "Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses.", "authors": [{"family": "Raoult", "given": "Didier", "initials": "D"}, {"family": "Zumla", "given": "Alimuddin", "initials": "A"}, {"family": "Locatelli", "given": "Franco", "initials": "F"}, {"family": "Ippolito", "given": "Giuseppe", "initials": "G"}, {"family": "Kroemer", "given": "Guido", "initials": "G"}], "type": "editorial", "published": "2020-03-02", "journal": {"title": "Cell Stress", "issn": "2523-0204", "volume": "4", "issue": "4", "pages": "66-75", "issn-l": "2523-0204"}, "abstract": "Coronaviruses (CoVs) are a large family of enveloped, positive-strand RNA viruses. Four human CoVs (HCoVs), the non-severe acute respiratory syndrome (SARS)-like HCoVs (namely HCoV 229E, NL63, OC43, and HKU1), are globally endemic and account for a substantial fraction of upper respiratory tract infections. Non-SARS-like CoV can occasionally produce severe diseases in frail subjects but do not cause any major (fatal) epidemics. In contrast, SARS like CoVs (namely SARS-CoV and Middle-East respiratory syndrome coronavirus, MERS-CoV) can cause intense short-lived fatal outbreaks. The current epidemic caused by the highly contagious SARS-CoV-2 and its rapid spread globally is of major concern. There is scanty knowledge on the actual pandemic potential of this new SARS-like virus. It might be speculated that SARS-CoV-2 epidemic is grossly underdiagnosed and that the infection is silently spreading across the globe with two consequences: (i) clusters of severe infections among frail subjects could haphazardly occur linked to unrecognized index cases; (ii) the current epidemic could naturally fall into a low-level endemic phase when a significant number of subjects will have developed immunity. Understanding the role of paucisymptomatic subjects and stratifying patients according to the risk of developing severe clinical presentations is pivotal for implementing reasonable measures to contain the infection and to reduce its mortality. Whilst the future evolution of this epidemic remains unpredictable, classic public health strategies must follow rational patterns. The emergence of yet another global epidemic underscores the permanent challenges that infectious diseases pose and underscores the need for global cooperation and preparedness, even during inter-epidemic periods.", "doi": "10.15698/cst2020.04.216", "pmid": "32292881", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "CST0270E115"}, {"db": "pmc", "key": "PMC7064018"}], "notes": [], "created": "2020-11-23T11:27:23.267Z", "modified": "2020-12-09T12:09:26.162Z"}, {"entity": "publication", "iuid": "6067731d14094c8ca594582c6a13d5ab", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6067731d14094c8ca594582c6a13d5ab.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6067731d14094c8ca594582c6a13d5ab"}}, "title": "Updated rapid risk assessment from ECDC on the outbreak of COVID-19: increased transmission globally.", "authors": [], "type": "journal article", "published": "2020-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "9", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.9.2003051", "pmid": "32156331", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7068166"}], "notes": [], "created": "2020-12-08T06:53:18.558Z", "modified": "2020-12-10T09:04:59.875Z"}, {"entity": "publication", "iuid": "6e5b06134a9e41f4a197a3dba1698631", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/6e5b06134a9e41f4a197a3dba1698631.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/6e5b06134a9e41f4a197a3dba1698631"}}, "title": "Updated rapid risk assessment from ECDC on the novel coronavirus disease 2019 (COVID-19) pandemic: increased transmission in the EU/EEA and the UK.", "authors": [{"family": "Eurosurveillance editorial team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "25", "issue": "10", "pages": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.10.2003121", "pmid": "32183937", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7078827"}], "notes": [], "created": "2020-12-08T06:55:01.572Z", "modified": "2020-12-10T09:04:15.038Z"}, {"entity": "publication", "iuid": "555a9a24a05249b9b88c00e2e32d0ac4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/555a9a24a05249b9b88c00e2e32d0ac4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/555a9a24a05249b9b88c00e2e32d0ac4"}}, "title": "Rapidly increasing cumulative incidence of coronavirus disease (COVID-19) in the European Union/European Economic Area and the United Kingdom, 1 January to 15 March 2020.", "authors": [{"family": "Kinross", "given": "Pete", "initials": "P"}, {"family": "Suetens", "given": "Carl", "initials": "C"}, {"family": "Gomes Dias", "given": "Joana", "initials": "J"}, {"family": "Alexakis", "given": "Leonidas", "initials": "L"}, {"family": "Wijermans", "given": "Ariana", "initials": "A"}, {"family": "Colzani", "given": "Edoardo", "initials": "E"}, {"family": "Monnet", "given": "Dominique L", "initials": "DL"}, {"family": "ECDC Public Health Emergency Team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "issn-l": null, "volume": "25", "issue": "11", "pages": null}, "abstract": "The cumulative incidence of coronavirus disease (COVID-19) cases is showing similar trends in European Union/European Economic Area countries and the United Kingdom confirming that, while at a different stage depending on the country, the COVID-19 pandemic is progressing rapidly in all countries. Based on the experience from Italy, countries, hospitals and intensive care units should increase their preparedness for a surge of patients with COVID-19 who will require healthcare, and in particular intensive care.", "doi": "10.2807/1560-7917.ES.2020.25.11.2000285", "pmid": "32186277", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7096777"}], "notes": [], "created": "2020-12-08T06:56:51.256Z", "modified": "2021-02-26T08:45:48.168Z"}, {"entity": "publication", "iuid": "eea6eb2eee9947eead710b14e91c253a", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/eea6eb2eee9947eead710b14e91c253a.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/eea6eb2eee9947eead710b14e91c253a"}}, "title": "Potential scenarios for the progression of a COVID-19 epidemic in the European Union and the European Economic Area, March 2020.", "authors": [{"family": "Johnson", "given": "Helen C", "initials": "HC"}, {"family": "Gossner", "given": "C\u00e9line M", "initials": "CM"}, {"family": "Colzani", "given": "Edoardo", "initials": "E"}, {"family": "Kinsman", "given": "John", "initials": "J"}, {"family": "Alexakis", "given": "Leonidas", "initials": "L"}, {"family": "Beaut\u00e9", "given": "Julien", "initials": "J"}, {"family": "W\u00fcrz", "given": "Andrea", "initials": "A"}, {"family": "Tsolova", "given": "Svetla", "initials": "S"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Ekdahl", "given": "Karl", "initials": "K"}], "type": "journal article", "published": "2020-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "9", "issn-l": null}, "abstract": "Two months after the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the possibility of established and widespread community transmission in the European Union and European Economic Area (EU/EEA) is becoming more likely. We provide scenarios for use in preparedness for a possible widespread epidemic. The EU/EEA is moving towards the 'limited sustained transmission' phase. We propose actions to prepare for potential mitigation phases and coordinate efforts to protect the health of citizens.", "doi": "10.2807/1560-7917.ES.2020.25.9.2000202", "pmid": "32156332", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7068161"}], "notes": [], "created": "2020-12-08T06:54:09.547Z", "modified": "2020-12-10T09:04:40.162Z"}, {"entity": "publication", "iuid": "9dc9d035aaaf46ebba4567bc2ce6c865", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/9dc9d035aaaf46ebba4567bc2ce6c865.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/9dc9d035aaaf46ebba4567bc2ce6c865"}}, "title": "First cases of coronavirus disease 2019 (COVID-19) in the WHO European Region, 24 January to 21 February 2020.", "authors": [{"family": "Spiteri", "given": "Gianfranco", "initials": "G"}, {"family": "Fielding", "given": "James", "initials": "J"}, {"family": "Diercke", "given": "Michaela", "initials": "M"}, {"family": "Campese", "given": "Christine", "initials": "C"}, {"family": "Enouf", "given": "Vincent", "initials": "V"}, {"family": "Gaymard", "given": "Alexandre", "initials": "A"}, {"family": "Bella", "given": "Antonino", "initials": "A"}, {"family": "Sognamiglio", "given": "Paola", "initials": "P"}, {"family": "Sierra Moros", "given": "Maria Jos\u00e9", "initials": "MJ"}, {"family": "Riutort", "given": "Antonio Nicolau", "initials": "AN"}, {"family": "Demina", "given": "Yulia V", "initials": "YV"}, {"family": "Mahieu", "given": "Romain", "initials": "R"}, {"family": "Broas", "given": "Markku", "initials": "M"}, {"family": "Bengn\u00e9r", "given": "Malin", "initials": "M"}, {"family": "Buda", "given": "Silke", "initials": "S"}, {"family": "Schilling", "given": "Julia", "initials": "J"}, {"family": "Filleul", "given": "Laurent", "initials": "L"}, {"family": "Lepoutre", "given": "Agn\u00e8s", "initials": "A"}, {"family": "Saura", "given": "Christine", "initials": "C"}, {"family": "Mailles", "given": "Alexandra", "initials": "A"}, {"family": "Levy-Bruhl", "given": "Daniel", "initials": "D"}, {"family": "Coignard", "given": "Bruno", "initials": "B"}, {"family": "Bernard-Stoecklin", "given": "Sibylle", "initials": "S"}, {"family": "Behillil", "given": "Sylvie", "initials": "S"}, {"family": "van der Werf", "given": "Sylvie", "initials": "S"}, {"family": "Valette", "given": "Martine", "initials": "M"}, {"family": "Lina", "given": "Bruno", "initials": "B"}, {"family": "Riccardo", "given": "Flavia", "initials": "F"}, {"family": "Nicastri", "given": "Emanuele", "initials": "E"}, {"family": "Casas", "given": "Inmaculada", "initials": "I"}, {"family": "Larrauri", "given": "Amparo", "initials": "A"}, {"family": "Salom Castell", "given": "Magdalena", "initials": "M"}, {"family": "Pozo", "given": "Francisco", "initials": "F"}, {"family": "Maksyutov", "given": "Rinat A", "initials": "RA"}, {"family": "Martin", "given": "Charlotte", "initials": "C"}, {"family": "Van Ranst", "given": "Marc", "initials": "M"}, {"family": "Bossuyt", "given": "Nathalie", "initials": "N"}, {"family": "Siira", "given": "Lotta", "initials": "L"}, {"family": "Sane", "given": "Jussi", "initials": "J"}, {"family": "Tegmark-Wisell", "given": "Karin", "initials": "K"}, {"family": "Palm\u00e9rus", "given": "Maria", "initials": "M"}, {"family": "Broberg", "given": "Eeva K", "initials": "EK"}, {"family": "Beaut\u00e9", "given": "Julien", "initials": "J"}, {"family": "Jorgensen", "given": "Pernille", "initials": "P"}, {"family": "Bundle", "given": "Nick", "initials": "N"}, {"family": "Pereyaslov", "given": "Dmitriy", "initials": "D"}, {"family": "Adlhoch", "given": "Cornelia", "initials": "C"}, {"family": "Pukkila", "given": "Jukka", "initials": "J"}, {"family": "Pebody", "given": "Richard", "initials": "R"}, {"family": "Olsen", "given": "Sonja", "initials": "S"}, {"family": "Ciancio", "given": "Bruno Christian", "initials": "BC"}], "type": "journal article", "published": "2020-03-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "9", "issn-l": null}, "abstract": "In the WHO European Region, COVID-19 surveillance was implemented 27 January 2020. We detail the first European cases. As at 21 February, nine European countries reported 47 cases. Among 38 cases studied, 21 were linked to two clusters in Germany and France, 14 were infected in China. Median case age was 42 years; 25 were male. Late detection of the clusters' index cases delayed isolation of further local cases. As at 5 March, there were 4,250 cases.", "doi": "10.2807/1560-7917.ES.2020.25.9.2000178", "pmid": "32156327", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7068164"}], "notes": [], "created": "2020-12-08T06:52:02.863Z", "modified": "2020-12-10T09:05:36.064Z"}, {"entity": "publication", "iuid": "7a56f791eb7449fda11f805ef6c6f22e", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/7a56f791eb7449fda11f805ef6c6f22e.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/7a56f791eb7449fda11f805ef6c6f22e"}}, "title": "Note from the editors: World Health Organization declares novel coronavirus (2019-nCoV) sixth public health emergency of international concern.", "authors": [], "type": "journal article", "published": "2020-02-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "5", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.5.200131e", "pmid": "32019636", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7014669"}], "notes": [], "created": "2020-12-08T06:50:47.542Z", "modified": "2020-12-10T09:07:14.293Z"}, {"entity": "publication", "iuid": "3f28068739f0480fb93dab85b6750c3c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/3f28068739f0480fb93dab85b6750c3c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/3f28068739f0480fb93dab85b6750c3c"}}, "title": "Latest updates on COVID-19 from the European Centre for Disease Prevention and Control.", "authors": [], "type": "journal article", "published": "2020-02-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "6", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.6.2002131", "pmid": "32070466", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7029450"}], "notes": [], "created": "2020-12-08T06:51:11.110Z", "modified": "2020-12-08T06:51:23.372Z"}, {"entity": "publication", "iuid": "8a6310427b8c4a0ea6204f8c69a060ef", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/8a6310427b8c4a0ea6204f8c69a060ef.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/8a6310427b8c4a0ea6204f8c69a060ef"}}, "title": "Latest assessment on COVID-19 from the European Centre for Disease Prevention and Control (ECDC).", "authors": [], "type": "journal article", "published": "2020-02-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "8", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.8.2002271", "pmid": "32127126", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7055041"}], "notes": [], "created": "2020-12-08T06:51:46.191Z", "modified": "2020-12-10T09:07:12.084Z"}, {"entity": "publication", "iuid": "4ddd8421feca423ca1949412569cae50", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/4ddd8421feca423ca1949412569cae50.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/4ddd8421feca423ca1949412569cae50"}}, "title": "Laboratory readiness and response for novel coronavirus (2019-nCoV) in expert laboratories in 30 EU/EEA countries, January 2020.", "authors": [{"family": "Reusken", "given": "Chantal B E M", "initials": "CBEM"}, {"family": "Broberg", "given": "Eeva K", "initials": "EK"}, {"family": "Haagmans", "given": "Bart", "initials": "B"}, {"family": "Meijer", "given": "Adam", "initials": "A"}, {"family": "Corman", "given": "Victor M", "initials": "VM"}, {"family": "Papa", "given": "Anna", "initials": "A"}, {"family": "Charrel", "given": "Remi", "initials": "R"}, {"family": "Drosten", "given": "Christian", "initials": "C"}, {"family": "Koopmans", "given": "Marion", "initials": "M"}, {"family": "Leitmeyer", "given": "Katrin", "initials": "K"}], "type": "journal article", "published": "2020-02-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "6", "issn-l": null}, "abstract": "Timely detection of novel coronavirus (2019-nCoV) infection cases is crucial to interrupt the spread of this virus. We assessed the required expertise and capacity for molecular detection of 2019-nCoV in specialised laboratories in 30 European Union/European Economic Area (EU/EEA) countries. Thirty-eight laboratories in 24 EU/EEA countries had diagnostic tests available by 29 January 2020. A coverage of all EU/EEA countries was expected by mid-February. Availability of primers/probes, positive controls and personnel were main implementation barriers.", "doi": "10.2807/1560-7917.ES.2020.25.6.2000082", "pmid": "32046815", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC7029448"}], "notes": [], "created": "2020-12-10T09:07:15.398Z", "modified": "2020-12-10T09:07:15.407Z"}, {"entity": "publication", "iuid": "18a18e7be6c948a69430c431929b1c8c", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/18a18e7be6c948a69430c431929b1c8c.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/18a18e7be6c948a69430c431929b1c8c"}}, "title": "Evaluation of a COVID-19 IgM and IgG rapid test; an efficient tool for assessment of past exposure to SARS-CoV-2", "authors": [{"family": "Hoffman", "given": "Tove", "initials": "T"}, {"family": "Nissen", "given": "Karolina", "initials": "K"}, {"family": "Krambrich", "given": "Janina", "initials": "J"}, {"family": "R\u00f6nnberg", "given": "Bengt", "initials": "B"}, {"family": "Akaberi", "given": "Dario", "initials": "D"}, {"family": "Esmaeilzadeh", "given": "Mouna", "initials": "M"}, {"family": "Salaneck", "given": "Erik", "initials": "E"}, {"family": "Lindahl", "given": "Johanna", "initials": "J"}, {"family": "Lundkvist", "given": "\u00c5ke", "initials": "\u00c5"}], "type": "journal-article", "published": "2020-01-01", "journal": {"title": "Infect Ecol Epidemiol", "issn": "2000-8686", "issn-l": "2000-8686", "volume": "10", "issue": "1", "pages": "1754538"}, "abstract": "COVID-19 is the most rapidly growing pandemic in modern time, and the need for serological testing is most urgent. Although the diagnostics of acute patients by RT-PCR is both efficient and specific, we are also crucially in need of serological tools for investigating antibody responses and assessing individual and potential herd immunity. We evaluated a commercially available test developed for rapid (within 15 minutes) detection of SARS-CoV-2-specific IgM and IgG by 29 PCR-confirmed COVID-19 cases and 124 negative controls. The results revealed a sensitivity of 69% and 93.1% for IgM and IgG, respectively, based solely on PCR-positivity due to the absence of a serological gold standard. The assay specificities were shown to be 100% for IgM and 99.2% for IgG. This indicates that the test is suitable for assessing previous virus exposure, although negative results may be unreliable during the first weeks after infection. More detailed studies on antibody responses during and post infection are urgently needed.", "doi": "10.1080/20008686.2020.1754538", "pmid": null, "labels": {"Type: Journal article": null, "Funder: VR": null, "Category: Imaging": null, "Category: Health": null, "Category: Other": null}, "xrefs": [], "notes": [], "created": "2020-11-04T06:47:15.391Z", "modified": "2021-02-26T08:46:12.946Z"}, {"entity": "publication", "iuid": "835438bc55a64fd2bab901dcb8287ac4", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/835438bc55a64fd2bab901dcb8287ac4.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/835438bc55a64fd2bab901dcb8287ac4"}}, "title": "Note from the editors: novel coronavirus (2019-nCoV).", "authors": [{"family": "Eurosurveillance editorial team", "given": "", "initials": ""}], "type": "journal article", "published": "2020-01-00", "journal": {"title": "Euro Surveill", "issn": "1560-7917", "volume": "25", "issue": "3", "issn-l": null}, "abstract": null, "doi": "10.2807/1560-7917.ES.2020.25.3.2001231", "pmid": "31992390", "labels": {"Type: Other": null}, "xrefs": [{"db": "pmc", "key": "PMC6988271"}], "notes": [], "created": "2020-12-10T09:07:13.182Z", "modified": "2020-12-10T09:07:13.192Z"}, {"entity": "publication", "iuid": "276c7b56c9bc482782475182bd6bf288", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/276c7b56c9bc482782475182bd6bf288.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/276c7b56c9bc482782475182bd6bf288"}}, "title": "Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS-CoV-2 in an ageing population, consider N-acetylcysteine as early therapeutic intervention", "authors": [{"family": "Nasi", "given": "Aikaterini", "initials": "A", "orcid": "0000-0002-9935-1008", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/42e476f1362242ee934f3f2d29c01647.json"}}, {"family": "McArdle", "given": "Stephanie", "initials": "S", "orcid": "0000-0001-6929-9782", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/b2f69bf332d74e7f814bc12f53c4bca1.json"}}, {"family": "Gaudernack", "given": "Gustav", "initials": "G"}, {"family": "Westman", "given": "Gabriel", "initials": "G"}, {"family": "Melief", "given": "Cornelis", "initials": "C"}, {"family": "Rockberg", "given": "Johan", "initials": "J"}, {"family": "Arens", "given": "Ramon", "initials": "R", "orcid": "0000-0001-5058-4110", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/440c6baa3803427fbd9001dfa4725247.json"}}, {"family": "Kouretas", "given": "Demetrios", "initials": "D"}, {"family": "Sj\u00f6lin", "given": "Jan", "initials": "J"}, {"family": "Mangsbo", "given": "Sara", "initials": "S", "orcid": "0000-0002-1355-2678", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8cf494629d8a4f9584ada4be16dff66b.json"}}], "type": "journal-article", "published": "2020-00-00", "journal": {"title": "Toxicology Reports", "issn": "2214-7500", "issn-l": "2214-7500", "volume": "7", "issue": null, "pages": "768-771"}, "abstract": "During the current COVID-19 pandemic, a need for evaluation of already available drugs for treatment of the disease is crucial. Hereby, based on literature review from the current pandemic and previous outbreaks with corona viruses we analyze the impact of the virus infection on cell stress responses and redox balance. High levels of mortality are noticed in elderly individuals infected with SARS-CoV2 and during the previous SARS-CoV1 outbreak. Elderly individuals maintain a chronic low level of inflammation which is associated with oxidative stress and inflammatory cytokine production, a condition that increases the severity of viral infections in this population. Coronavirus infections can lead to alterations of redox balance in infected cells through modulation of NAD + biosynthesis, PARP function along with altering proteasome and mitochondrial function in the cell thereby leading to enhanced cell stress responses which further exacerbate inflammation. ROS production can increase IL-6 production and lipid peroxidation resulting in cell damage. Therefore, early treatment with anti-oxidants such as NAC during COVID-19 can be a way to bypass the excessive inflammation and cell damage that lead to severe infection, thus early NAC as intervention should be evaluated in a clinical trial setting.", "doi": "10.1016/j.toxrep.2020.06.003", "pmid": "32632359", "labels": {"Funder: KAW/SciLifeLab": null, "Type: Review": null, "Research Area: Drug discovery and repurposing of drugs": null}, "xrefs": [{"db": "pii", "key": "S2214-7500(20)30336-X"}, {"db": "pmc", "key": "PMC7301821"}], "notes": [], "created": "2020-11-04T07:09:44.267Z", "modified": "2022-02-06T17:39:19.668Z"}, {"entity": "publication", "iuid": "2ecd356aee194db0b6de668cf27aac00", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2ecd356aee194db0b6de668cf27aac00.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2ecd356aee194db0b6de668cf27aac00"}}, "title": "Principles of mental health care during the COVID-19 pandemic", "authors": [{"family": "Kuzman", "given": "Martina Rojnic", "initials": "MR", "orcid": "0000-0001-9646-0594", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/8fad1012ef6d4d528af166ab01e06c9d.json"}}, {"family": "Curkovic", "given": "Marko", "initials": "M", "orcid": "0000-0002-4855-2133", "researcher": {"href": "https://publications-covid19.scilifelab.se/researcher/29ca35067e324a22839263700264ecab.json"}}, {"family": "Wasserman", "given": "Danuta", "initials": "D"}], "type": "journal-article", "published": "2020-00-00", "journal": {"title": "Eur Psychiatry", "issn": "0924-9338", "volume": "63", "issue": "1", "pages": "e45", "issn-l": null}, "abstract": "We describe the basic principles of mental health care during the COVID-19 pandemic that should be endorsed by the mental health professional associations and incorporated in the health strategies for the management of the COVID-19 pandemic. The main principle is that there should be no substantial differences in the provision of health care for COVID-19 between persons with pre-existing mental health disorders and the ones without previous disorders. Subsequently, the organization of the health care should reflect that as well. These principles should (a) prevent the possible effects of stigmatizing attitudes toward mental health issues, possibly leading to potentially deleterious situations, such as psychiatric patients being treated (even temporarily) separately from other patients, in psychiatric facilities, where the staff is not equipped and trained adequately for the management of COVID-19; (b) highlight the fact that patients with mental health disorders are at greater risk for developing serious complications of COVID-19 infection due to other factors-they often smoke and have comorbidities such as hypertension, diabetes, all associated with higher morbidity and mortality from COVID-19 infection; (c) highlight that measures should be taken to minimize the risk of the spread of infection in psychiatric wards/institutions; (d) provide a general framework for the reorganization of mental health services toward the provision of services for persons in need, including frontline medical workers and patients with COVID-19 without previous mental health problems as well as for persons with pre-existing mental health problems under new circumstances of pandemic.", "doi": "10.1192/j.eurpsy.2020.54", "pmid": "32431255", "labels": {"Type: Other": null}, "xrefs": [{"db": "pii", "key": "S0924933820000541"}, {"db": "pmc", "key": "PMC7267055"}], "notes": [], "created": "2020-11-25T09:08:56.007Z", "modified": "2021-12-06T13:17:17.161Z"}, {"entity": "publication", "iuid": "2255c0c2ec314e95ab1e0d30d475f231", "links": {"self": {"href": "https://publications-covid19.scilifelab.se/publication/2255c0c2ec314e95ab1e0d30d475f231.json"}, "display": {"href": "https://publications-covid19.scilifelab.se/publication/2255c0c2ec314e95ab1e0d30d475f231"}}, "title": "COVID-19: A case report from Bangladesh perspective", "authors": [{"family": "Jahan", "given": "Yasmin", "initials": "Y"}, {"family": "Rahman", "given": "Sohel", "initials": "S"}, {"family": "Rahman", "given": "Atiqur", "initials": "A"}], "type": "journal-article", "published": "2020-00-00", "journal": {"title": "Respir Med Case Rep", "issn": "2213-0071", "volume": "30", "issue": null, "pages": "101068", "issn-l": null}, "abstract": "A 34-year-old man without any significant medical history or comorbidities, suddenly developed fever, and shortness of breath, thereby admitted to the emergency department of a tertiary care hospital, Dhaka, Bangladesh. He had neither a history of traveling to Coronavirus disease (COVID) prone areas nor a direct contact of COVID positive patients. His chest X-ray revealed ground-glass opacity in the right middle and lower zone of the lung. The first polymerase chain reaction (PCR) test on throat and nasal swabs for the COVID upon admission was negative. Based on the chest X-ray result, RT-PCR was done again resulted positive. The patient was primarily treated with chloroquine and azithromycin. On full recovery, he was discharged from the hospital on day 12, after two subsequent throat swab samples tested negative by PCR (24 hours apart). He was encouraged to maintain home quarantine for at least the next 14 days. SARS-CoV-2 RNA by swab remained negative and the blood sample shows the presence of antibody (both IgM and IgG) in his follow-up visit (after 7 days of hospital discharge).", "doi": "10.1016/j.rmcr.2020.101068", "pmid": "32363143", "labels": {"Type: Journal article": null, "Category: Health": null}, "xrefs": [{"db": "pmc", "key": "PMC7194830"}, {"db": "pii", "key": "S2213-0071(20)30173-8"}, {"db": "pii", "key": "101068"}], "notes": [], "created": "2020-12-10T07:25:21.814Z", "modified": "2021-12-06T12:57:00.418Z"}]}
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